bluuebunny/crossref_metadata_2025 huggingface dataset:
ЗАБЕЗПЕЧЕННЯ КРИПТОГРАФІЧНОГО ЗАХИСТУ ДЕРЖАВНИХ ІНФОРМАЦІЙНИХ РЕСУРСІВ
Authors: Каткова Т.І.
Published: October 2022

Розвиток нових інформаційних технологій і впровадження комп‘ютерних систем в усі сфери людської діяльності стали причиною різкого зростання інтересу широкого кола користувачів до проблеми інформаційного захисту. Захист інформації – це сукупність методів і засобів, що забезпечують цілісність, конфіденційність і доступність інформації за умови впливу на неї загроз природного або штучного характеру, реалізація яких може призвести до завдання шкоди власникам і користувачам інформації. Провідна роль у забезпеченні інформаційної безпеки в інформаційно-телекомунікаційних системах відводиться криптографії, одними із головних задач є: забезпечення конфіденційності, цілісність та автентичність даних, що передаються. Криптографія – наука про математичні методи забезпечення конфіденційності (неможливості прочитання інформації сторонніми) і автентичності (цілісності і справжності автора) інформації. На сьогодні криптографія, як галузь знань, та криптографічний захист інформації, як окрема галузь діяльності, стосується: питань шифрувальної справи, новітніх технологій електронної торгівлі, систем автоматизованого управління, звітування та контролю тощо. Формування високопродуктивних методів шифрування(розшифрування) з високою криптографічною стійкістю є важливою складовою у вирішенні питання інформаційної безпеки. Методи криптографічного захисту інформації – це системи шифрування інформації, алгоритми захисту від нав‘язування фальшивої інформації (МАС-коди та алгоритми електронного цифрового підпису) та криптографічні протоколи розподілу ключів, автентифікації та підтвердження факту прийому (передачі) інформації. Криптографічна стійкість методів криптографічного захисту інформації – це властивість криптографічних алгоритмів і криптографічних протоколів, що характеризує їх здатність протистояти методам дешифрування (процес несанкціонованого відновлення оригіналу тексту повідомлення). Для сучасної криптографії характерне використання відкритих алгоритмів шифрування, що припускають використання обчислювальних засобів. На сьогодні відомо більше десятка перевірених методів шифрування, які при використанні ключа достатньої довжини і коректної реалізації алгоритму, роблять шифрований текст недоступним для криптоаналізу (наука "зламування" криптографічних перетворень).
В процесі роботи нами розглянуто криптографічні методи та засоби захисту інформації, які є одним з елементів комплексної системи захисту інформації. Висвітлено види шифрування, а також сутність електронних підписів. Наведено правові підстави застосування криптографічних методів захисту інформації.
ЩОДО ПИТАННЯ ПРОГНОЗУВАННЯ З ВИКОРИСТАННЯМ КЛАСИЧНИХ І НЕЙРОМЕРЕЖЕВИХ МЕТОДІВ МАШИННОГО НАВЧАННЯ
Authors: Мальцев А.Ю.
Published: October 2022

У статті описано принципи прогнозування з використанням класичних і нейромережевих методів машинного навчання. Наголошено, що механізм прогнозування застосовується у фінансовій сфері, для прогнозування рівня продажів, інфляції, реального внутрішнього валового продукту, цін на нафту, золото, валюту, тощо. Описано принципи генетичного алгоритму, кластеризації, математико-статичні методи, методи нейромережевого прогнозування. Підкреслено, що у порівнянні з математико-статичними методами кластерний аналіз не накладає умов на тип об'єктів, що розглядаються, тому дозволяє досліджувати різноманіття вихідних даних довільної природи. Здійснено порівняння алгоритмів кластеризації. Наведено типову структуру нейронної мережі з прямим зв'язком, математично обґрунтовано принцип визначення похибки роботи штучної нейронної мережі. За для визначення рівня ефективності моделей прогнозування, здійснено оцінку за допомогою математичних статистичних показників: ступінь дисперсії, середньоквадратична помилка, середнє абсолютне відсоткове відхилення, медіана абсолютних відхилень, середньоквадратична похибка прогнозу, середня абсолютна похибка. Наведено схему інформаційних зв’язків при застосуванні системи прогнозування за допомогою класичних і нейромережевих методів машинного навчання. У статті наголошено, що прогнозування за допомогою класичних і нейромережевих методів машинного навчання є програмним комплексом, який призначено для прогнозування даних. Таблично представлено результати аналізу моделей прогнозування. Зазначається, що перша модель поділяє дані на групи, таким чином, щоб кожна група складалася зі схожих об'єктів, а об'єкти різних груп були відмінними один від одного, у другій моделі, на відміну від першої, перелік груп не заданий чітко, а визначається у процесі роботи алгоритму, третя модель за один крок здійснює обробку деякої популяції рядків. Підкреслено, що вибір різних нейрометодів залежить від конкретного завдання і не може бути визначено однозначно, а для досягнення найкращого результату необхідно експериментувати з вибором заходів відстаней, інколи ж навіть змінювати алгоритм.
La dialyse péritonéale : ce que le réanimateur doit savoir
Authors: Boyer Annabel , Lanot Antoine , Béchade Clémence , Lobbedez Thierry
Published: October 2022

La dialyse péritonéale (DP) est un traitement efficace d’épuration extra-rénale (EER) qui reste sous-utilisé comme traitement de l’insuffisance rénale aigue (IRA) en réanimation, malgré de nombreux avantages spécifiques tels que la stabilité hémodynamique, l’absence d’abord vasculaire ainsi qu’un coût inférieur à celui de l’hémodialyse. La pandémie à Sars-Cov2 a souligné l’utilité de cette modalité de dialyse dans un contexte de pénurie de personnel soignant et de ressource. En DP, c’est la membrane péritonéale qui est utilisée pour réaliser les échanges d’eau et de solutés, entre le dialysat injecté dans la cavité abdominale au moyen d’un cathéter et le sang du patient, grâce à la diffusion et à la convection. La prescription doit renseigner le type de soluté, le volume intra-péritonéal, le volume de dialysat total ainsi que la modalité de DP. Plusieurs complications spécifiques de la DP, infectieuses et non infectieuses, peuvent mettre en péril le bon déroulement de la technique. Dans cette mise au point, nous reverrons les principes physiologiques de la DP, la place de la DP dans le traitement de l’IRA, la prescription de la DP, l’impact de la DP sur la mécanique ventilatoire ainsi que la gestion des complications spécifiques à la DP.
Modelowanie energochłonności układnicy magazynowej w zadanym cyklu pracy
Authors: Wolska Karolina
Published: October 2022

W pracy zaproponowano modele układów napędowych układnicy magazynowej. Na ich podstawie przeprowadzono badania symulacyjne energochłonności układnicy w zadanym wzorcowym cyklu pracy. Wzorcowy cykl pracy układnicy uwzględniał 10 losowo rozłożonych lokalizacji gniazd regałowych, które układnica obsługiwała w trybie zatowarowania oraz w trybie kompletacji. Celem tych badań było określenie zużycia energii oraz umożliwienie porównywania efektywności urządzeń pochodzących od różnych dostawców. Wyniki symulacji wykazały zdecydowanie różne zużycie energii z zależności od trybu pracy układnicy. Są one inspiracją do doskonalenia modeli obliczeniowych i metody oceny różnych urządzeń.
Perspective of sol-gel hydrophobic silica deposited using low-pressure cold spray and ultrasonic atomizing for automotive coatings
Authors: Gibas Anna , Gąsiorek Jolanta
Published: October 2022

The automotive sector is under constant pressure to minimize fuel consumption and reduce pollution emissions while maintaining a declining tendency for weight and cost reduction. This makes the material selection process a major of engineering design considerations. In the paper, the main automotive requirements were formulated to analyze the potential of selected deposition (low pressure cold spray and ultrasonic atomizing) and material fabrication (sol-gel method) techniques for application in the automotive industry.
Peri-Implantitis: A Comprehensive Overview for the General Dental Practitioner
Authors: Wiedemann Thomas G
Published: October 2022

Considering the significant role of implants in contemporary dentistry, practitioners must be able to acknowledge and anticipate the clinical signs and the appropriate treatment measures of peri-implant disease. The article aims to provide an overview of peri-implantitis, outlining its prevalence, etiology, risk factors, diagnosis, and management for the general practitioner. Peri-implantitis is a pathological condition usually associated with plaque. It exhibits inflammation around the peri-implant mucosa and subsequent progressive bone loss. While some patients show clinical signs, most implants exhibiting peri-implant disease are asymptomatic. As a result, clinicians must first develop an accurate diagnosis based on clinical and radiographic findings. The diagnosis of peri-implantitis usually done if the following criteria are met:

1) presence of bleeding,

2) progressive bone loss, and

3) increased probing depths.

It is widely accepted that peri-implantitis is difficult to manage and prevention is the best form of treatment. Early diagnosis and management are essential to the successful clinical outcomes in the treatment of peri-implantitis. While non-surgical treatment may not always be effective but should always come first in patients with advanced peri-implantitis. Good oral hygiene, the location of the damaged implant, and the configuration of the bone defect, appear to be the key factors that influence the clinical predictability surgical interventions.
Comparison of the Effectiveness of Orthodontic Treatment with Adenotonsillectomy Procedures in Children with Obstructive Sleep Apnea (OSA)
Authors: Achmad Harun
Published: October 2022

Background: Obstructive Sleep Apnea Syndrome (OSA) is a syndrome of total or partial obstruction of the airways, leading to significant disturbances with varying clinical impact. In children, the main cause is thought to be overgrowth (hypertrophy) of the tonsils and adenoids, as well as structural abnormalities in Pierre Robin and Down Syndrome. The airway structures are significantly narrowed in children with head-face bone abnormalities or craniofacial anomalies, causing them to experience airway obstruction even in the absence of adenoid hypertrophy. The incidence of OSA in children needs to be observed as well as rising risk factors such as obesity. Pediatric obstructive sleep apnea (OSA) is typically treated with an adenotonsillectomy and the use of orthodontic procedures including rapid maxillary expansion and mandibular advancement devices. Each approach has different treatment advantages. Systematic reviews and meta-analysis of OSA treatments have been reported, however there have been relatively few comparisons of various treatments. In a systematic review of the evidence for the efficacy of AT and orthodontic treatment, Templier et al. concluded that combined AT orthodontic treatment (RME and/or MAD) was more effective than either therapy alone for treating OSA in pediatric patients.

Objective: To systemically analyze the literature on the effectiveness of orthodontic treatment with adenotonsillectomy surgery in children with obstructive sleep apnea (OSA) and to identify differences in the two treatments’ effectiveness.

Conclusion and implications: The effectiveness of adenotonsillectomy, orthodontic treatment, and orthodontic treatment combined with adenotonsillectomy was assessed in children with mild OSA and mandibular retrognathia. That study, which needed a large sample size (352 children) and had a high dropout rate, revealed that combine orthodontic adenotonsillectomy (RME and/or MAD treatment) was more effective when given simultaneously than when given individually for treating OSA in pediatric patients. To date, the effectiveness of these two treatments cannot currently be compared due to a lack of strong evidence. If the treatment outcomes were unsatisfactory at 7 months after the initial treatment, subjects could receive further treatment following assessment by a stomatologist and ear, nose, and throat (ENT) specialist.

Limitations: Of the 10 publications included in this review, 8 were randomized controlled trials, the remaining 2 non-randomized research journals were vulnerable to many biases that impair the certainty of the evidence gained, especially by confounding factors and the lack of control groups.
Relationship Between Anxiety/Depression Mood Disorders and Insomnia in Patients with Pain Syndromes in Primary Health Care: A Cohort Study
Authors: Rodriguez Erik Munoz
Published: October 2022

Introduction: Chronic pain and mental health disorders are common in the general population, prevalence of chronic pain ranges from 2% to 40%, and the prevalence of mental health disorders ranges from 17% to 29%. Chronic pain is associated with irritability, depression, anxiety and sleep problems such as insomnia. However, the appearance of anxiety and depression has been described as a consequence of chronic pain.

Aims: To determine the sociodemographic characteristics and the association between pain syndromes and mood disorders in individuals treated in primary care.

Materials and methods: A prospective cohort study was undertaken in a primary care medical center for four months with patients whose pain was the reason for consultation. Scales such as DN4, VAS, Beck's criteria, and DSM-V were applied, and the sociodemographic characteristics of these individuals were determined.

Results: A total of 132 patients who met the inclusion criteria were recruited. Of these, 81.81% (108) were women, 18.18% were men (24). The mean age for both sexes was 37.9 and the mean duration in hours of each painful episode was 14.35 hours. The proportion of the disorders that was noted were as follows: insomnia in 0.303, anxiety 0.265, depression 0.090. Those who presented with anxiety or depression and another disorder was 0.053. Patients who did not develop any of the diseases of interest in this study 0.185.

Discussion: The coexistence and overlap of mood disorders and insomnia in patients suffering from pain syndromes, which have little or no importance when assessing patients in primary health care centers, are under-diagnosed. However, broadening the clinical history, and correctly using diagnostic tools for mood disorders increases their diagnosis rate, ignoring the positive relationship that exists between these disorders.

Conclusions: Pain disorders trigger neuropsychiatric complications. Depression, anxiety, and insomnia worsen episodes of pain. However, the correct diagnostic approach and the application of adequate management greatly reduce the complications of these types of disorders.
Elbow Posterolateral Synovial Fold Syndrome: A Case Series With A Modified Arthroscopic Technique
Authors: Perez-Carro Luis
Published: October 2022

Background: Posterolateral synovial fold syndrome is a rare entity on elbow pathology. Careful evaluation of clinical presentation and radiological imaging is essential to obtain the diagnosis. Treatment is usually resection of the synovial fold with arthroscopy.

Objective: To retrospectively evaluate and review the functional outcomes, findings and results after arthroscopic surgery in a case series of patients with posterolateral synovial fold syndrome treated with a modified arthroscopic technique.

Methods: Between 2010 and 2020, 6 patients diagnosed with posterolateral synovial fold syndrome were treated with average of 12 months follow-up (SD ± 17.3) they were evaluated for clinical symptoms, radiological signs and arthroscopic findings. Patient outcome was assessed pre- and postoperatively by the Mayo Elbow Performance Index (MEPI), which assesses pain, ROM, stability and function. Statistical analysis was performed with the student’s t-test. P=0.05 were considered statistically significant. The study was approved by ethics committee of Hospital Clinica Mompia, Santander, Spain.

Results: In all cases the synovial fold was swollen and thickened with some synovitis adjacent to the fold on the radio capitellar joint. Mild chondromalacia was observed on the capitellum and the posterolateral zone of the radial head. No pathology was observed at the anterior compartment of the elbow. All patients showed up a clinical improvement with the disappearance of pain and snapping and returned to physical activities. No loss of motion was observed. No complication or recurrence of the symptoms appeared during the 12month of follow-up. The preoperative MEPI score of 64.1 points (SD ± 5.8) had significant improvement to 92.5 (SD ± 8.2) on postoperative at 12 months of follow up.

Conclusion: Management of a symptomatic posterolateral synovial fold is successful and effective with our proposed arthroscopic technique.
Incidence of Accommodative Excess Reported at Binocular Vision Therapy Clinic of a Tertiary Eye Care Centre Among School Children During Pandemic Lockdown
Authors: Sharma Preeti
Published: October 2022

Purpose: This study aimed to find out the aspects of incidence of accommodative excess among school-going children due to excessive near work during pandemic period in relation to various parameters like indoor-outdoor activity & screen time.

Methodology: A retrospective study was conducted among 176 individual children between 5-17 years of age reported with ocular or non-ocular asthenopic symptoms. A detailed test had performed to check various accommodative parameters like NPA, MEM, NRA, PRA, MAF, BAF, as well as vergence parameters like NPC, NFV and PFV. One monthly follow up had been performed all these necessary binocular vision assessments tests & checked the status.

Results: Out of 267 patients, 51 of them had accommodative excess (28.97%). It was found that 29% children with less screen exposure & 46% of children with excessive screen exposure had developed accommodative excess which became significant (fisher’s exact 0.027). The percentage of children with less indoor activity & excessive indoor activity with accommodative excess were 17% & 48% respectively (p value 0.052). Among all the Accommodation parameters, Accommodative facility (100%) becomes an excellent marker followed by poor NPA (33%), NRA/PRA (27%) & MEM (10%). Also children with long screen & indoor exposure developed with poor NRA more easily.(18% short exposure & 54% long exposure).

Conclusion: Children with prolonged near work & indoor activities suffered more compared to children with some outdoor activities & less screen exposure. Secondary convergence insufficiency can be there along with accommodative excess. A proper vision therapy and appropriate counselling about the visual hygiene & environmental modifications should always be advocated to save our future shapers of this beautiful world.
Genetic Divergence and Selection of Genitors Aiming to Generate Variability in Common Bean Lines
Authors: Lampi Dique José Eulário , Pedro César , José Fernando Custódio Jorge , Quinhentos Maria Da Luz , Barbosa Ivan De Paiva , Bungala Leonel Tarcísio da Cristina , Dias Domingos , Mendes António Arlindo , Carneiro José Eustáquio de Souza
Published: October 2022

The objective of this work was to evaluate the genetic divergence between common bean strains from the breeding program of the Agricultural Research Institute of Mozambique (IIAM)-Zonal Centre (CZC) and to identify potential genitors to generate segregating populations with high average and wide genetic variability. Five common bean lines were evaluated in a randomized block design with three repetitions. The quantitative traits evaluated were leaf area index, days to 50% flowering, days to maturity, several pods per plant, 100 seed weight, and yield, while the qualitative traits were growth habit, epicotyl colour, leaf colour intensity, leaf roughness, fresh pod colour, grain colour, grain size, and flower colour. The data obtained were submitted to variance analysis and grouping of means by the Scott-Knott test. The relative importance of characters was evaluated by the Singh. Clustering was performed by the Tocher optimization method and distance projection in the 2D plane, using the generalized Mahalanobis distance as a measure of dissimilarity. The degree of preservation of genetic distances in the 2D plane was assessed by the Cohenetic Correlation Coefficient, distortion, and stress. The LPA54 and Bonus lines were highlighted by direct selection based on the performance per se of their characteristics. Genetic variability was checked for the trait’s days to 50% flowering several of pods per plant, and 100-seed weight and the strains were separated into two groups. The crosses between (G19833, LPA54, Manteiga, and Bonus) with the strain DOR364 there is the potential for obtaining hybrids with higher heterotic effect and segregating populations with high variability. The traits of 100-seed weight, pods per plant, epicotyl colour, and grain size were the most important in the discrimination of the strains
PENGARUH MOTIVASI, PROMOSI JABATAN DAN KOMPENSASI TERHADAP KINERJA KARYAWAN PT BANK NEGARA INDONESIA.TBK KC JAMBI
Authors: Fazliawinata Mohd Iqbal
Published: October 2022

This study aims to analyze the influence of motivation, job promotion and employee performance compensation at PT Bank Negara Indonesia (Persero) Tbk. This study uses a questionnaire as an instrument to take a sample of 50 respondents. The sampling method used was nonprobability sampling. The analytical method used in this research is multiple linear regression analysis. The independent variables in this study, namely motivation, promotion and compensation, explain the dependent variable, namely the employee's performance of 99.6% and the remaining 04% or determined by other variables not included in this analysis or research. The results of this study indicate that motivation, promotion and position have a significant effect on employee performance because they have a significance value <0.05.

Abstract is basically an English version of abstrak. All components in abstract are written in the same style as in abstrak. The word “Abstract” and the paragraph is written in Italics.
PENGARUH KEBIJAKAN DEVIDEN DAN KEPUTUSAN INVESTASI TERHADAP NILAI PERUSAHAAN PADA PERUSAHAAN SEKTOR PERTAMBANGAN DI BURSA EFEK INDONESIA
Authors: Pramurza Dede
Published: October 2022

Penelitian ini bertujuan untuk mengetahui pengaruh: (1) Kebijakan dividen, (2) Keputusan Investasi, terhadap Nilai Perusahaan pada perusahaan sektor pertambangan yang terdaftar di Bursa Efek Indonesia. Periode penelitian yang digunakan adalah 2009-2018. Penelitian ini tergolong sebagai penelitian ex post facto, bersifat asosiatif kausal, dan pendekatan kuantitatif.  Populasi dalam penelitian ini adalah perusahaan pertambangan yang terdaftar dalam Bursa Efek Indonesia (BEI) periode 2009-2018. Teknik pengambilan sampel menggunakan purposive sampling. Teknik analisis data menggunakan regresi linier berganda. Hasil penelitian menunjukkan bahwa: (1) Kebijakan dividen tidak berpengaruh terhadap Nilai Perusahaan dengan nilai koefisien regresi sebesar-0.626 dan tingkat signifikan 0,221. (2) Keputusan Investasi berpengaruh positif terhadap Nilai Perusahaan dengan nilai koefisien regresi sebesar 0.048 dan tingkat signifikan 0,038 (3) dan Kebijakan Dividen dan Keputusan Investasi tidak berpengaruh terhadap Nilai Perusahaan manufaktur yang perusahaan pertambangan yang terdaftar dalam Bursa Efek Indonesia (BEI) periode 2009-2018 dengan nilai F hitung sebesar 2,313 dan nilai signifikansi 0,108. Hasil uji adjusted R2 pada penelitian ini diperoleh nilai sebesar 0,075. Hal ini menunjukkan bahwa Nilai Perusahaan dipengaruhi oleh Keputusan Investasi, Keputusan Pendanaan, dan Kebijakan Dividen sebesar 7,5%, sedangkan sisanya sebesar92,5% dipengaruhi oleh faktor lain yang tidak diteliti dalam penelitian ini.
ANALISIS KECURANGAN TERHADAP PRAKTIK LAPORAN KEUANGAN PT ASURANSI JIWASRAYA (PERSERO) DI BEI TAHUN 2017-2019
Authors: Rahmiyati Rahmiyati
Published: October 2022

This research discusses fraud against the financial reporting practices of PT Asuransi Jiwasraya (Persero) 2017-2019, where the information presented in the financial statements must not have the interest of one party because it will harm the other party. This study aims to determine the occurrence of fraud in the practice of financial reporting at PT Asuransi Jiwasraya (Persero) in 2017-2019. This study uses secondary data. The population in this study is the company PT Asuransi Jiwasraya (Persero) which is listed on the Indonesia Stock Exchange in 2017-2019. This research uses descriptive quantitative method with descriptive statistical analysis tools and literature study collection methods. The results show that the income at PT Asuransi Jiwasraya (Persero) in 2017-2019 has increased quite significantly while the expenses for PT Asuransi Jiwasraya have also increased but overall it is very significant. This shows that the income at PT Asuransi Jiwasraya (Persero) has increased significantly when their expenses are high. In the case of this financial statement, the company should as much as possible reduce the expenses on the company so that they are more focused on company revenue.
PENGARUH SOFTWARE SAP DALAM MENINGKATKAN KINERJA KARYAWAN BAGIAN KEUANGAN DAN AKUNTANSI PADA PT. PERKEBUNAN NUSANTARA VI
Authors: Heriyani Heriyani
Published: October 2022

A Employee performance is of course one of the important components for the company because it affects the company's operations. This study aims to analyze the effect of SAP software in improving employee performance in finance and accounting at PT. Perkebunan Nusantara VI, used a questionnaire as an instrument to take a sample of 30 respondents. The analytical method used in this research is multiple linear regression analysis. The independent variables in this study are software quality, information quality, software user satisfaction and the impact of using accounting software, while the dependent variable is employee performance of 65.3%, the remaining 34.7% is influenced by other variables. The results of this study indicate that the variables of software user satisfaction and the impact of using accounting software have a significant effect on employee performance with a significant value <0.05 with a value of Tcount < Ttable (-2.182 < 2.060) and (6.064 > 2.060). Meanwhile, the variables of software quality and information quality have no effect on employee performance because they have a significant value > 0.05 with a value of Tcount < Ttable (-0.293 < 2.060) and (-1.347 < 2.060). For the overall effect, the value of Fcount > Ftable is (11.870 > 2.76) with a significant value of 0.000 <0.05.
Targeted RNA-sequencing analysis for fusion transcripts detection in tumor diagnostics: assessment of bioinformatic tools reliability in FFPE samples
Authors: Capone Iolanda , Bozzi Fabio , Dagrada Gian Paolo , Verderio Paolo , Conca Elena , Busico Adele , Testi Maria Adele , Monti Valentina , Duca Matteo , Proto Claudia , Damian Silvia , Piccolo Alberta , Perrone Federica , Tamborini Elena , Devecchi Andrea , Collini Paola , Lorenzini Daniele , Vingiani Andrea , Agnelli Luca , Pruneri Giancarlo
Published: October 2022

Aim: Diagnostic laboratories are progressively introducing next-generation sequencing (NGS) technologies in the routine workflow to meet the increasing clinical need for comprehensive molecular characterization in cancer patients for diagnosis and precision medicine, including fusion-transcripts detection. Nevertheless, the low quality of messenger RNA (mRNA) extracted from formalin-fixed paraffin-embedded (FFPE) samples may affect the transition from traditional single-gene testing approaches [like fluorescence in situ hybridization (FISH), immunohistochemistry (IHC), or polymerase chain reaction (PCR)] to NGS. The present study is aimed at assessing the overall accuracy of RNA fusion transcripts detection by NGS analysis in FFPE samples in real-world diagnostics.
Methods: Herein, NGS data from 190 soft tissue tumors (STTs) and carcinoma cases, discussed in the context of the institutional Molecular Tumor Board, are reported and analyzed by FusionPlex© Solid tumor kit through the manufacturer’s pipeline and by two well-known fast and accurate open-source tools [Arriba (ARR) and spliced transcripts alignment to reference (STAR)-fusion (SFU)].
Results: The combination of FusionPlex© Solid tumor with ArcherDX® Analysis suite (ADx) analysis package has been proven to be sensitive and specific in STT samples, while partial loss of sensitivity has been found in carcinoma specimens.
Conclusions: Albeit ARR and SFU showed lower sensitivity, the use of additional fusion-detection tools can contribute to reinforcing or extending the output obtained by ADx, particularly in the case of low-quality input data. Overall, our results sustain the clinical use of NGS for the detection of fusion transcripts in FFPE material.
NATIONAL AND CULTURAL CONNOTATIONS OF ZOOLOGICAL ADJECTIVES METAPHORICALLY CHARACTERIZING HUMAN EYES IN RUSSIAN AND CHINESE
Authors:   Centre for Russian Studies of Henan University, Hong Zhang
Published: October 2022

This article is devoted to a comparative analysis of zoonymic adjectives that metaphorically characterize human eyes in the Russian and Chinese languages to reveal the national and cultural characteristics of these units. Zoolexic is an integral part of any linguoculture and forms a special layer of the vocabulary of the language, occupies an important place among the lexical units of the language system. Metaphor-zoomorphism is a way of linguistic representation - the characteristics of a person through the assimilation of his external appearance, behavioral features, character traits, etc., to the image of an animal. Such metaphors are ethnoculturally marked, which gives rise to a special interest in their study in a comparative aspect.
POETIC DISCOURSE OF VSEVOLOD NIKANOROVICH IVANOV IN THE CONTEXT OF HISTORIOSOPHICAL VIEWS OF THE EURASIAN WRITER
Authors:   Pacific State University, Yakimova S. I.
Published: October 2022

The article is devoted to the consideration of the genre and thematic features of the poetic discourse of Vsevolod Nikanorovich Ivanov (1888-1971), a representative of the Far Eastern emigration (1920-1940s) in the context of the influence, on the one hand, of the traditions of Russian classical poetry and the philosophical and aesthetic searches of the Silver Age figures, on the other hand, the philosophy and culture of China, the country that received the exiles from Russia. The author of the article, revealing the commitment to the poetic discourse of Vs. N. Ivanov to ancient mythological culture, as one of the fundamental foundations of European culture and Russian classics, complements his characterization by considering the poetic heritage of Vs. N. Ivanov Eurasian in the context of the dialogue between the cultures of the West and the East.
House Arrest as a Preventive Measure in Criminal Proceedings: Features of Modern Assessment
Authors:   Russian State University of Justice (Moscow), Kachalova Oksana V.
Published: October 2022

The author, considering house arrest in the system of preventive measures in criminal cases, comes to the conclusion that house arrest is a relatively “mild”, but, nevertheless, a form of actual deprivation of liberty, is chosen only if there are the same grounds and conditions as detention. For detention and house arrest, the courts must apply the same grounds and conditions, assuming that there is sufficient evidence to believe that a person may abscond, obstruct the investigation, continue to engage in criminal activity; as well as the validity of the accusation of committing a specific crime, the impossibility of applying a milder preventive measure. House arrest may not be chosen arbitrarily in the absence of conditions and grounds for its application, even if there is a request for this by the defense.
Ensuring by the Court the Right to Defense in Certain Categories of Criminal Cases
Authors:   Russian State University of Justice (Moscow), Markovicheva Elena V. , Смирнова Ирина Георгиевна ,   East Siberian Branch, Russian State University of Justice, Irkutsk, Russia
Published: October 2022

The article highlights several issues related to the provision by the court of the right of defense of minors and criminally prosecuted persons with mental disorders. The authors analyze the reasons that imped law enforcement in such criminal cases. Several suggestions are formulated to improve the judicial practice of ensuring by the courts the right to defense in certain categories of cases, provided for by Chapters 50 and 51 of the Code of Criminal Procedure of the Russian Federation.
Medieval Thinkers on the Organization of Supreme Power (Form of Government)
Authors:   Russian State University of Justice (Moscow), Zolotukhina Natalia M. , Vlasova Tatiana V.
Published: October 2022

As a rule, Russia of the XI–XIII centuries is called an early feudal monarchy in modern historical literature. In pre-revolutionary historiography, there was a widespread statement about Russia’s initial commitment to a monarchical form of government. In foreign literature, it has been transformed into an idea of the imperial thinking that has long been characteristic of Russia. Currently, the expansion of the source base, achieved as a result of scientific discoveries and the application of new research methods by modern historians, philologists, philosophers and historians of state and law, political and legal doctrines, has largely changed the perception of the level of general cultural and political and legal development of Medieval Russia. Russian mediev all thinkers gave various recommendations on the organization of state power in the country, the creation of an image of an ideal ruler, the limitation of supreme power. The article examines the ideas about the organizationof the supreme power of three of the most prominent thinkers of the XI – first quarter of the XIII centuries: Metropolitan Hilarion, the great Prince of Kiev Vladimir Monomakh and an unknown author who hid his name under the nickname Daniel the Sharpener.
The Contract of Participation in Shared Construction as the Sale of a Future Thing: Problems of Protecting the Right to Proper Quality of the Construction Object
Authors:   Russian State University of Justice (Moscow), Vanin Vitaly V.
Published: October 2022

Problem statement. The absence in the current legislation of a direct solution to the question of the place of the contract on participation in shared construction in the system of civil law contracts creates prerequisites for different approaches to the legal qualification of this contract in the doctrine and judicial arbitration practice, the predominant of which is the qualification of it as a contract of sale of a future thing. Goals and Objectives of the study. Identification of individual problems of protecting the right to proper quality of a shared-equity construction object that arise when qualifying a contract of participation in shared-equity construction as the sale of a future thing, the formation of proposals to overcome them. Investigation of the procedural features of the protection of the right to proper quality of the common property of an apartment building as an element of the subject of the contract. Research methods. Dialectical, analysis, synthesis, comparative-legal, formal-legal, linguistic. Results. Brief conclusions. It is concluded that there are grounds for qualifying a shared construction contract as a named sui generis contract, which opens up the possibility of legal assurance of the quality of the work result before their completion, thereby creating additional guarantees for the protection of the rights of a participant in shared construction. The necessity of applying the construction of an indirect class action in the protection of the right to the proper quality of the common property of an apartment building is justified.
Implementation of the Rules on the Public Contract (Compulsory Contract) in the System of Legislation on the Carriage of Goods by Rail
Authors:   North-Western Branch, Russian State University of Justice, St. Petersburg, Baukin Vyacheslav G.
Published: October 2022

The relative independence of railway legislation to a certain extent hinders the applicability of the principles of civil law to the carriage of cargo. This threatens the unity of the legal regulation of property relations. One of the fundamental provisions limiting the freedom of contract in the interests of the economic system as a whole is the recognition of the public nature of business contracts. The public nature of the contract (compulsory contract) of carriage should prevent the arbitrariness of the carrier’s actions and ensure fairness in the provision of transport services. To what extent does the sectoral legislation comply with the principles of civil law? Is the importance of the rules on public contract (compulsory contract) in a special legal regime not diminished? The main task is to assess the degree of compliance of the provisions of the railway transport legislation with the rules on the public contract (compulsory contract). Particular tasks are: to establish the formal inconsistency of industry norms on cargo transportation with civil legislation; to identify contradictions in the procedure for concluding and conditions for the contract of railway cargo transportation to the idea of a public contract (compulsory contract); to prove the need for changes in the design of auxiliary transport contracts from the position of publicity of the contract (compulsory contract) of carriage. The tasks set are solved on the basis of a critical understanding of the norms of civil and railway transport legislation. Methods of comparative jurisprudence were used to prepare the source material for this study. The work is primarily of the nature of a theoretical search, contractual and law enforcement practice was studied at the initial stage of data analysis in order to best understand the essence of the regulations. Based on the conducted research, it should be stated that the implementation of the rules on the public contract(compulsory contract) requires a direct indication in the railway transport legislation. The agreement on the terms and procedure for concluding a cargo transportation contract, especially the procedure for accepting an application for transportation, does not take into account, and in some cases directly contradicts the principles of civil legislation. The system of auxiliary transport contracts creates conditions for a significant restriction of the rights and interests of cargo owners. Based on theoretical conclusions, the paper formulates proposals aimed at improving the current legislation.
Problems of Proof in the Process of Application by Courts of a Preventive Measure in the Form of Detention at the Stage of Preliminary Investigation
Authors:   Russian State University of Justice (Moscow), Kobzarev Fedor M. , Zakharyan Alexey A.
Published: October 2022

The application of detention as a restrictive measure is connected with restriction of freedom and personal immunity as an inalienable right of every person protected by the Constitution of the Russian Federation and the statutes of international law. In this regard, a judicial procedure, specifically, the court session, is the main guarantee of legality and validity of the decision to arrest a suspect or accused person. Thereof, the preparation and conduct of a court session on consideration of motions of interrogators or investigators for arrest, as a form of procedural interaction between the court and the prosecutor, involves establishment of facts included, i. e., the fact in proof as it relates to grounds of the considered restrictive measure and in preventing, in particular, the court, from exceeding the limits of proof. The purpose of this paper is to identify problems in substantiating the conditions and grounds for detention, carried out mainly when implementing supervisory powers of the court and the prosecutor, and to substantiate the relationship of these powers and to develop proposals on improvement of a legal framework to implement these powers.
Side effects of skin toxicity in targeted therapy of malignant neoplasms (literature review)
Authors: Бородавина Екатерина , Исаев Павел , Полькин Вячеслав , Ильин Алексей , Крылов Валерий , Плугарь Алиса , Иванов Сергей , Каприн Андрей
Published: October 2022

An overwhelming number of new agents, including targeted agents with unique mechanisms of action, are available in oncology practice today. Along with the benefit of new treatments for patients comes the unfamiliarity of associated toxicities and learning the best methods to minimize side effects. Side effects of chemotherapeutic agents, including toxic erythema and mucositis, are common and may require cessation of treatment if associated with discomfort, superinfection, or negative impact on quality of life. This article reviews the cutaneous adverse reactions and treatment options of targeted, multikinase inhibitors.
Embryonal-based surgery for pancreatic head cancer
Authors: Вервекин Илья , Трушин Антон , Курсенко Роман , Зайцев Данила , Беляев Михаил , Захаренко Александр
Published: October 2022

Introduction. More than half of patients with pancreatic head cancer (PHC) have locally advanced tumor and/or distant hematogenous metastases at the time of diagnosis. Thus, the prognosis for most patients diagnosed with PHC is poor, with a 5-year survival rate of 8% at all stages. The current decade has witnessed a rapid evolution in pancreatic head cancer surgery. In particular, this, alternative as compared to the classical approach to pancreatoduodenal resection (PDR) treatments begant appear, such as the Artery-first approach, Total Mesopancreas Excision (TMpE), No-touch approach. All of the above methods mainly aim to increase resectability and the frequency of R0 resection, and to improve long-term oncological outcom.
Based on the analyzed literature, we came to the conclusion that an increase in the volume of surgical intervention in patients with pancreatic cancer does not improve oncological outcomes. Extended lymph node dissection has not shown any benefit in meta-analyses. There are no studies proving the effectiveness and feasibility of performing mesopancreasectomy.
The role of the saliva biomarkers in the diagnostics of the oral mucosal cancer
Authors: Кочурова Екатерина , Кудасова Екатерина , Николенко Владимир , Панферова Ольга
Published: October 2022

The review provides information on the main saliva biomarkers in squamous cell carcinoma of the oral mucosa. Squamous cell carcinoma of the oral mucosa is the most common among the oncologic diseases of the maxillofacial region. Patients still appeal for help at the last stages of neoplastic process despite accessible visualization. The dentist is the first physician who can suspect a neoplastic process. However, in order to receive advice from oncologists and to have a final clinical diagnosis made, the patient needs to visit a number of extra hospital departments. Free unstimulated oral fluid is an excellent diagnostic material, in particular, for the early diagnosis of diseases of the oral cavity. Saliva has a direct contact with the pathology of the oral mucosa; its sampling does not require sterile instrumentation and special skills, which increases its informational value.
The literature published over the last 5 years originated from the databases PubMed MedLine, The Cochrane Library, EMBASE, Global Health and CyberLeninka platforms, and eLibrary.Ru has been analyzed. The biomarkers that have been studied for the moment has insufficient specificity for diagnostics or differentiation of the oral cavity diseases. This makes it relevant to study to investigate the expression of saliva biomarkers in patients with burdened tumor history as well as correlations with clinical state of the patient’s oral cavity.
The frequency and spectrum of hereditary mutations in the TP53 gene in an extensive study involving Russian breast cancer patients
Authors: Степанов Илья , Васильева Елена , Соколенко Анна , Имянитов Евгений
Published: October 2022

Introduction. Breast cancer is the most common tumor localization in heritable TP53-related cancer syndrome (hTP53rc), previously called «Li-Fraumeni syndrome». This syndrome is characterized by the occurrence of a hereditary mutation in the TP53 gene.
We wanted to demonstrate the relatively high incidence of hTP53rc in the structure of hereditary breast tumors, as well as to present a correct algorithm for the diagnosis of TP53-associated breast cancer in the Russian population.
Aim. To study the incidence and spectrum of hereditary mutations in the TP53 gene in breast cancer patients.
Materials and methods. We studied 1726 samples from breast cancer patients using next generation sequencing (NGS) to detect hereditary mutations in the TP53, BRCA1/2 genes. The feature of this study was the creation of «enriched» sample collection ― all samples from patients with any mutations in the BRCA1/2 genes were excluded from sample group using a special algorithm. CHEK2, NBS1, and BLM genes in 1322 from 1726 samples were additionally tested by PCR for the most common mutations in the population: CHEK2 del5395 (del ex9-10), CHEK2 c.444+1G>A [IVS2+1G>A], CHEK2 1100delC, NBS1 657del5, BLM p.Q548X [c.1642C>T]. Such a technique was used for detecting the carriership of double mutations and could make it possible to assess the features of the clinical manifestations of such situations in case of their detection. Usage of an algorithm based on NGS with the study of several genes made it possible to exclude samples with mutations and form a final sample group by which the occurrence of hTP53rc was calculated.
Results. The occurrence of hTP53rc in the formed sample was 10/1494, which is 0.67%.
Conclusion. The frequency of hTP53rc in the Russian population is obviously insufficiently estimated. The contribution of hTP53rc to the structure of hereditary breast cancer should be taken into account.
Combined PCR-based approach for analysis of ALK, ROS1, RET translocations in lung cancers
Authors: Тюрин Владислав , Алексахина Светлана , Анускина Александра , Иевлева Аглая , Митюшкина Наталья , Преображенская Елена , Романько Александр , Соколенко Анна , Харитонова Елена , Того Александр , Кулигина Екатерина , Имянитов Евгений
Published: October 2022

The discovery of recurrent EGFR mutations, ALK and ROS1 translocations, together with the development of effective targeted drugs, has become a real breakthrough in the treatment of lung cancer. Molecular diagnosis of alteration in these genes has already become a mandatory part of evaluating patients with non-small cell lung cancer.
The paper presents a combined diagnostic approach, which allows the identification of known chimeric transcripts and new variants of translocations. Using this technique, we identified eight fusions that had not been previously described in the literature.
Here, we analyze the spectrum of translocations of receptor tyrosine kinases ALK, ROS1, RET in the Russian population, which seems relevant in connection with the known ethnic and geographic heterogeneity of lung cancer.