bluuebunny/crossref_metadata_2025 huggingface dataset:
High-risk sexual behaviors and health services needs among bisexual men in Peru: a cross sectional study
Authors: Gervasi Giovani Díaz , Canto Yordanis Enriquez , Alvirio Luis Menacho
Published: April 2024

Objective
This study aims to identify factors linked to effective bisexual behavior among self-identified bisexual men in Lima, with a focus on high-risk sexual behaviors and access to health services.
Materials and methods
We conducted a cross-sectional study with 560 participants who responded to a semi-structured survey. Those who reported having intercourse with a woman in the year prior to the survey were classified as effective bisexuals.
Results
Effective bisexuality (48.9%) was associated with being 36 years or older and engaging in sexual intercourse under the influence of alcohol (OR: 2.90, 95% CI: 1.65–5.10, p < 0.01; OR: 3.33, 95% CI: 2.13–5.21, p < 0.01; respectively). Conversely, non-effective bisexuality was significantly associated with self-reporting HIV positive status and engaging in unprotected anal intercourse with any male sexual partner (OR: 0.43, 95% CI: 0.19–0.95, p: 0.037; OR: 0.69, 95% CI: 0.46–1.02, p: 0.04; respectively).
Conclusion
Bisexual self-identification does not necessarily correlate with intercourse with both men and women. Instead, it relates to various psychosocial factors that result in distinct behavioral patterns and health needs. It is crucial to develop prevention strategies targeting bisexual men, considering their limited access to health services, sociodemographic characteristics, and the prevalence of high-risk sexual behaviors.
Scalable Version-aware Data Placement for In-Memory Databases
Authors: Zhang First Qian , Wei Second Jianhao , Zhang Third Shichen , Luan Fourth Hao , Gong Fifth Xueqing
Published: April 2024

Most modern in-memory database systems rely on multi-version concurrency control to support real-time data analysis without interfering with concurrent writes. However, this is not a good fit for heterogeneous workloads. We find that long version chains are the root cause of the throughput reduction. In this paper, we exploit a scalable version-aware data partitioning and placement approach for heterogeneous workloads that incorporates a suite of optimized techniques to significantly reduce the overheads incurred both during the initial placement and during version ingestion at runtime. The experiment results show that the proposed approach achieves 2x performance improvement compared with existing state-of-the-art approaches.
All about the neutron from lattice QCD
Authors: Gupta Rajan
Published: April 2024

I describe how simulations of lattice QCD using the path integral formulation provide the two basic quantum mechanical properties of QCD, its ground state in which correlation functions are calculated, and Fock state wavefunctions between which matrix elements of operators are calculated. Both constructs are stochastic, so unfortunately one gets no intuitive picture or even qualitative understanding of what they look like, nevertheless they contain and display all the subtleties of the quantum field theory. Today, these simulations provide many quantities that are impacting phenomenology and experiments. I illustrate the methods and the steps in the analysis using, as examples, three observables: the isovector charges of the nucleon, the contribution of the quark’s intrinsic spin to the nucleon spin, and the pion-nucleon sigma term.
All order merging of high energy and soft collinear resummation
Authors: Andersen Jeppe R. , Hassan Hitham , Jaskiewicz Sebastian
Published: April 2024

We present a method of merging the exclusive LO-matched high energy resummation of High Energy Jets (HEJ) with the parton shower of PYTHIA which preserves the accuracy of the LO cross sections and the logarithmic accuracy of both resummation schemes across all of phase space. Predictions produced with this merging prescription are presented with comparisons to data from experimental studies and suggestions are made for further observables and experimental cuts which highlight the importance of both high energy and soft-collinear effects.
Λ(1520) resonance production with respect to transverse spherocity using EPOS3+UrQMD
Authors: Malik Nasir Mehdi , Sambyal Sanjeev Singh
Published: April 2024

Resonances are sensitive to the properties of the medium created in heavy ion collision. They also provide insight into the properties of the hadronic phase. Studying the dependence of the yield of resonances on transverse spherocity and multiplicity allows us to understand the resonance production mechanism with event topology and system size, respectively. The results reported pertain to \Lambda(1520)Λ(1520), using predictions from EPOS3+UrQMD event generator.
INTEGRATED APPROACH TO PAIN MANAGEMENT: YOGA, MANUAL THERAPY, FASCIA RELEASE, NERVE MOBILIZATION TECHNIQUES, OSTEOPATHIC MANIPULATIVE TREATMENT, CHIROPRACTIC CARE AND KINEMATIC AND KINETIC CHAINSANALYSIS& MUSCULOSKELETAL DYNAMICS
Authors:   Surat, India. MIAP - L 16617, GSCPT - GPC15788( Bachelor in Physiotherapy BPT, FOMT Fellowship in Osteopathy and Manipulation Therapy, Master Fitness Trainer IAFT Indian Academy of Fitness Training, Pilates and Power Yoga Trainer IAFT Indian Academy of Fitness Training)MalayJagjivanGondalia, Surat, India., Bhagat Amisha
Published: April 2024

Chronic pain affects millions worldwide, presenting a complex challenge to conventional medical approaches. This abstract explores an integrated approach to pain management, amalgamating principles from yoga, manual therapy, fascia release, nerve mobilization, Osteopathic Manipulative Treatment, Chiropractic Careand Kinematic and Kinetic ChainsAnalysis and Musculoskeletal Dynamics. By synergizing these modalities, practitioners address pain comprehensively, targeting its multifaceted origins and manifestations.Yoga, renowned for its mind-body connection, offers a repertoire of postures and breathing exercises tailored to alleviate pain and enhance flexibility. Manual therapy techniques, including myofascial release and joint mobilization, address muscular imbalances and restore tissue integrity. Fascia release strategies delve deeper, releasing tension in the connective tissue matrix, thereby enhancing movement quality and reducing discomfort.Nerve mobilization practices target neural tension, promoting optimal nerve glide and alleviating symptoms associated with nerve compression. Concurrently, Osteopathic Manipulative Treatment, Chiropractic Care, Kinematic and Kinetic ChainsAnalysis and Musculoskeletal Dynamics to identify and rectify movement dysfunctions, ensuring harmonious joint mechanics and reducing stress on susceptible structures.Furthermore, this integrated approach extends beyond physical interventions, incorporating mindfulness practices and lifestyle adjustments to modulate pain perception and promote overall well-being. Multidisciplinary collaboration and patient education foster empowerment and long-term adherence to personalized pain management plans.In conclusion, theIntegration of Yoga, Manual Therapy, Fascia Release, Nerve Mobilization Techniques, Osteopathic Manipulative Treatment, Chiropractic Care and Kinematic and Kinetic Chains Analysis & Musculoskeletal Dynamicsrepresents a promising paradigm shift in pain management. By embracing the interconnectedness of mind, body, and environment, this holistic approach strives to restore function, alleviate suffering, and enhance the quality of life for individuals grappling with chronic pain.
PREGNANCY INDUCED BELLS PALSY: AN IN DEPTH EXAMINATION OF THERAPEUTIC MODALITIES AND ADJUNCTIVE MEASURES
Authors:   Department of Pharmacy Practice, Bapuji Pharmacy College, Davangere, Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka, India., K. Moncy Sherin , Biju Joel ,   Department of Pharmacy Practice, Bapuji Pharmacy College, Davangere, Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka, India., H. Sabarinath ,   Bapuji Pharmacy College, Davangere, Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka, India.
Published: April 2024

Background: Bells palsy, a unilateral facial nerve paralysis, often presents challenges in diagnosis and management, especially when occurring during pregnancy and associated with preeclampsia. This case report aims to delineate the clinical manifestation, therapeutic interventions and outcome of preeclampsia-induced Bells palsy during pregnancy, emphasizing the importance of multidisciplinary care and post natal follow-up. Case Description: A 29-year-old gravid individual at 40 weeks of gestation presented with right sided facial weakness and hypertension, diagnosed with preeclampsia-induced Bells palsy. Treatment included antihypertensive medications, corticosteroids and close monitoring. Labor induction resulted in a healthy deliver, with satisfactory outcomes for both mother and baby. Conclusion: Early recognition, prompt treatment initiation and multidisciplinary management are essential in optimizing maternal and fetal outcomes in pregnant individuals with Bells palsy. Continued research efforts are needed to refine therapeutic approaches and improve care.This case underscores the importance of interdisciplinary care and vigilance in pregnant individuals with Bells palsy, highlighting the need for further research to optimize management strategies in this unique population.
A CASE REPORT ON THIAZIDE INDUCED HYPONATREMIA ADDRESSING AN UNDERESTIMATED COMPLICATION
Authors: Biju Joel , K. Moncy Sherin
Published: April 2024

Hyponatremia is a common and mostly unnoticed electrolyte imbalance in hospitalized patients. Attention and medical management depends on level of depletion below the normal sodium values and presence or absence of symptoms. Drug induced hyponatremia, arising from renal water retention is predominantly attributed to the Syndrome of Inappropriate Diuresis (SIAD). Hyponatremia manifest with signs of escalation in intracranial pressure such as headache, nausea and vomiting, particularly in case of acute onset with significant serum sodium reduction. Urgent medical interference is called for as symptoms ascend to altered consciousness encompassing confusion, drowsiness, seizures and coma. Various drugs such as Argenine Vasopressin Analogue (AVP analogues), Vasopressin Type II (V2) receptor agonist, diuretics, thiazide like agents induce hyponatremia by various mechanisms. Critical in restoring the serum sodium level is the cessation of implicated agent, coupled with the provision of necessary additional support including 3% NaCl, dexamethasone and fluid restriction. Here is a case report of 63 year old female patient with a diagnosis of euvolemic hyponatremia, induced by hydrochlorothiazide. The patient presented with complaints of drowsiness, altered sensorium and 8-10 episodes of vomiting. Laboratory investigation revealed a significant drop of 106 mmol/L in serum sodium, decreased serum chloride and an elevated D- Dimer. The patient was treated in ICU with 3%normal saline, antibiotics and antihypertensive along with prophylactic anticoagulants. Once the patient condition was satisfactory the patient was moved to wards and later discharged.
NONVIOLENT STRUGGLE AND UNCERTAINTY: SOME PERCEPTIONS OF TIBETAN DIASPORA IN DELHI
Authors:   Doctoral Fellow, Department of Sociology Aligarh Muslim University, Aligarh, U.P, India, 202002., Ahmad Rayees
Published: April 2024

The present study argues that there is a need to explore peoples perceptions of non-violent struggle and their life experience with non-violent struggle which can enrich the debate of the contemporary relevance of non-violent struggle. To explore this, the Tibetan diaspora from Delhi is taken as a case for this purpose, who have adopted non-violent struggle for more than six decades as of now. In-depth interviews were carried out in a Tibetan settlement at MajnuKaTilla in Delhi. Twenty-fiverespondents were interviewed using purposive sampling.Their views are mostly pessimistic about the non-violent approach, given its high rate of unsuccessfulness and its negligible impact on China. The lackadaisical approach of international peace keeping organisations towards their non-violent approach is also responsible for it.These reasons are compelling some of them to think of violence as an alternative tool to achieve the desired end. To address these radical tendencies, efforts like educating Tibetans about M K Ghandi, Martin Luther king Jr. and Nelson Mandelas contribution and the systematic utilization of non-violent strategies in an innovative way to achieve the goal might help. The study concludes with the fact that International peace keeping organisations especially United Nations can make a significant contribution in internationalising the Tibetan issue and provide peaceful solution.
BRIEF REVIEW ON MICROBIAL PIGMENTS AND THEIR PROSPECTS
Authors:   Dev Bhoomi Medical College of Paramedical Sciences, Dev Bhoomi Uttarakhand University, Chakrata Road, Manduwala, Naugaon, 248007, Dehradun, Uttarakhand, India., Khanduri Naresh , Nautiyal Pallawi ,   DIET Dehradun, Mayur Vihar, Sahastradhara Road, 248001, Dehradun, Uttarakhand, India.
Published: April 2024

The large number of microorganisms present in nature, as well as their ease of cultivation, contributes to the advantage in the extraction and manufacture of natural colours or pigments. Microbial pigments are classified as secondary metabolites and are mostly formed owing to poor metabolism during stressful situations. These microbial pigments are safe for human use, have increased biodegradability, and are more environmentally friendly, making them suitable for a variety of applications in the pharmaceutical, textile, cosmetic and food sectors. The therapeutic character of bacterial pigments is demonstrated by their antibacterial, anticancer, cytotoxic and outstanding antioxidant activities. Identifying novel microbiological sources and improving process parameters are two areas of focus for affordable pigment production. This also suggests that future generations will rely on microbial pigments rather than manmade colorants for a sustainable lifestyle. This article has attempted to take a brief idea on microbial pigments and their prospects in different sectors.
Understanding the Dynamics of Female Bullying
Authors: Rilveria Loida
Published: April 2024

The research aimed to explain the dynamics of female bullying and its causes and characteristics. Bullying’s influence on schools and society was becoming a growing problem; it affected the person being bullied and the bully, which might lead to anxiety, depression, sleep issues, decreased academic success, and school dropout and more likely to attempt suicide. With this, many types of research were conducted to identify factors surrounding bullying; however, it lacked research converging on female bullying. Female bullying might not exist for many, but it was considered more dangerous than male bullying because it attacked its victims in social and psychological aspects, causing them to seek vengeance or, worse, attempt suicide. The research applied a qualitative research method corresponding to a case study design. Qualitative data consisted of open-ended information gathered through interviews and observation. It is found that the causes of female bullying are identity crisis, family and social alienation, bullying experiences, overwhelming emotions, and a low tolerance for other people’s physical appearance or characteristics. It further discloses that female bullying usually uses subtle attacks in verbal bullying, physical bullying, and social bullying, which characterizes it from any other form of bullying.
Performance of Windu Shrimp (Penaeus monodon) Cultivated in a Silvofishery Pond with the Application of Phytoimmune®
Authors: Eko Falah Muhammad , Hardi Esti Handayani , Pagoray Henny , Saptiani Gina , Agustina Agustina
Published: April 2024

This study aim to evaluated the effects of using FITOIMUN® (mixture Boesenbergia pandurata and Solanum ferox), in pellet feed on tiger prawn (P. monodon) survival, weight gain, daily growth rate, and feed conversion ratio. A t-test with two treatments and four replications was did in this investigation. In this treatment, phytoimmune concentrations were 0 mLkg (PO) and 24 mL/kg (P1). The UPTD Seed Center for Brackish Water and Seawater Manggar provided the tiger prawn (P. monodon) used by PL 42 0,10±0,30 g. Feeding the addition of the extract with a dose equal to 5% of the shrimp's weight three times per day at 08.00, 13.00, and 17.00 WITA. Shrimp are culturing in empang parit silvofishery ponds using cages that are 4x2x1,1 m in size with 8 plots of waring as barriers. Shrimp care is done for 4 weeks, and growth observations are made as well as weekly survival tests. According to the findings, survival was 70% at P1 and 68% at P0. The  results of weighing the average value at PO (0,38 g) and P1 (0,48 g), the daily growth rate of the average value at PO (4,07%) and P1 (5,91%), and the conversion ratio feed at P0 (1,78) and P1 (1,73). In this investigation, the average water quality was 28,90°C, 19,2 ppt of salinity, 7,33 pH, and 4,31 ppm of  DO. The results of feeding tiger prawns (P. monodon) FITOIMUNⓇ 24 mL/kg feed revealed higher values for survival, weight increase, daily growth rate, and feed conversion ratio but no substantially different results (P>0, 05).
Online Correspondence in Writing Courses as a Space for Conceptual Foundations of Linguistic Education
Authors: Sologub Ol'ga
Published: April 2024

The paper deals with the organization of linguistic education aimed at developing communicative and speech skills. The research concentrated on its textual component in foreign students as part of a writing course. The study was part of the project on linguistic and didactic potential of online correspondence, which highlighted a problem area in the speech behavior of foreign students who were in correspondence with Russian native speakers. The issue had to deal with the text organization of letters. The research team addressed the speech and thinking activity of the foreign students and, subsequently, turned to the cognitive tools for arranging the written and speech material, i.e., the frame. The frame analysis revealed a linguodidactic genre frame model with the stages of framing and reframing. During the framing stage, the students mastered the actual communicative-speech material to form the content of the subject-situational frame as an integral part of the genre frame. Further development was expansion-oriented. The framing made it possible to acquire textual norms, which led to the text frame, i.e., the second component of the genre frame. The reframing stage was aimed at developing the textual competence based on context complication and stylistic transformations of the original meanings. The article introduces various types of lexical, syntactical, and textual transformations, as well as stylistic transformations that allow non-native speakers to express the same meaning with stylistically diverse linguistic means.
Impact of Irritable Bowel Syndrome (IBS) on Quality of Life; a Systematic Review
Authors: Khalil M Usman , Waleed Muhammad , Kamal M Usama , Waseem M Usama , Ahmad M Usman , Khan Ammad Waheed , Saeed Athar Ahmed
Published: April 2024

Background: IBS is a prevalent GIT disorder known to affect millions worldwide, causing distressing symptoms like abdominalpain, bloating, and altered bowel habits. Understanding the impact of IBS on quality of life is crucial.Objective: To censoriously gauge the existing literature on the effects of irritable bowel syndrome on the health, social life, andacademic performance of affected peopleMethods: We performed a systematic review of relevant literature from different databases like PubMed and Google Scholar onthe impact of irritable bowel syndrome on quality of life. To ensure transparency in this systemic review, we strictly followedPRISMA guidelines.Results: We selected 17 studies after strictly following our inclusion criteria. Every study employed different ways to assess theimpact on the quality of life. Four studies highlighted that a greater degree of work impairment was seen among patients withirritable bowel syndrome. Seven studies highlighted that anxiety and depression were more prevalent. Moreover, IBS seems to bemore prevalent among females and was also associated with GIT-specific anxiety.Conclusion: This systematic review underscores the multifaceted impact of IBS on individuals' quality of life, encompassinghealth-related quality of life, work productivity, daily activities, and mental health. It also suggests a gender-related susceptibilityto IBS, particularly in females. These findings collectively emphasize the need for comprehensive care and support for individualsliving with IBS to improve their overall well-being.
Characterisation of basin water allocation benefit function using a sigmoid-type S-curve logistic equation
Authors: Ishak Ahmad Fakhri , Lee Wei Koon , Lim Foo Hoat
Published: April 2024

As water allocation (WA) is reduced due to water scarcity in a river basin, the benefit function for the domestic water users and the economic sectors declines accordingly. Using the sigmoid-type equation, which is ubiquitous in natural and man-made systems, this study shows that the S-curve behaviour can be seen in a broad range of basin WA scenarios. A questionnaire survey reveals that progressive water supply cutback results in a mild initial hassle but builds up to an elaborate inconvenience and subsequently a diminished shock to the water users. The economic benefit of water consumption based on 8-year data of states in Malaysia shows evidence of the S-curve characteristics where lesser developed states tend to benefit more as water consumption increases. The model allows the sectorial benefit (and impact) level to be approximated as a function of basin water availability. The mathematical quantification, in lieu of qualitative descriptors, is useful as an integral component in water prioritisation and WA decision-making to provide an empirical assessment of optimum basin-wide benefit.
Using the precipitation concentration index for characterizing the rainfall distribution in the Levant
Authors: Salameh Ala A. M.
Published: April 2024

Climate change leads to altered spatial and temporal patterns of precipitation due to activating the hydrological cycle. This study analyzes the distribution of precipitation concentration over the Levant in 1970–2018 for the first time at various time scales. The precipitation concentration index (PCI) was calculated using a quality-controlled time series from 167 meteorological stations. Trends were calculated using a Mann–Kendall nonparametric test, and a nonparametric Mann–Whitney test was used to determine the statistical significance of the differences between the mean sub-periods. The Levant can be divided into three regions, a strongly irregular concentration in south Palestine and Jordan as well as east Jordan; an irregular concentration in center/north Palestine, north Jordan, and east Syria; and a moderately irregular concentration over the Syrian coast. The annual precipitation concentration index (PCI) for the Levant, Palestine, and Syria non-significantly increased by 0.33, 0.32, and 0.22 unit/decade, respectively. Significant increasing trends occurred in the northwest of the West Bank, with averages of 0.75 unit/decade. The seasonal rainfall distribution tends to be uniform in winter and spring, mainly for south Levant, whereas the annual rainfall tends to be more concentrated. The autumn PCI significantly decreased for the Levant, Palestine, and Syria by −0.46, −0.61, and −0.54 units/decade, respectively.
Assessing the impact of global carbon dioxide changes on atmospheric fluctuations in Iran through satellite data analysis
Authors: Mousavi Seyed-Mohsen , Mobarghaee Dinan Naghmeh , Ansarifard Saeed , Darvishi Golnaz , Borhani Faezeh , Naghibi Amir
Published: April 2024

Atmospheric Carbon Dioxide (CO2), a significant greenhouse gas, drives climate change, influencing temperature, rainfall, and the hydrologic cycle. This alters precipitation patterns, intensifies storms, and changes drought frequency and timing of floods, impacting ecosystems, agriculture, water resources, and societies globally. Understanding how global CO2 fluctuations impact regional atmospheric CO2 levels can inform mitigation strategies and Facilitate water resources management. The study investigates how global CO2 fluctuations affect atmospheric CO2 concentrations (XCO2) in Iran from 2015 to 2020, aiming to inform mitigation strategies against climate change. XCO2 data OCO-2 satellite and CO2 surface flux data from the Copernicus Atmosphere Monitoring Service (CAMS) were analyzed. Over the 6 years, XCO2 in Iran increased steadily by 12.66 ppm, mirroring global rises. However, Iran's CO2 surface flux decreased, with slight increases in anthropogenic emissions but decreased natural and total fluxes. Monthly patterns of XCO2 and surface flux exhibited variations, with XCO2 reaching its zenith in spring and dipping to its lowest point during summer, while surface flux peaked during the summer months. The results reveal a significant discrepancy between Iran's surface CO2 flux and atmospheric XCO2 trends. While Iran's anthropogenic emissions increased barely from 2015–2020, its natural and total CO2 fluxes decreased. However, XCO2 increased steadily over this period, indicating the dominant impact of global rather than local factors on Iran's XCO2. Curbing worldwide greenhouse gas output is imperative to disrupt the current trajectory of climate change. Reporting CO2 levels can inform climate mitigation plans, reducing emissions to combat global warming and minimize global impacts on the hydrologic cycle.
Evaluación del Complejo Convectivo a Mesoescala en el Perú, caso 14 de noviembre del 2003
Authors: Quispe G. Nelsón , García V. Jerónimo , Avalos R. Grinia
Published: April 2024

El presente estudio tiene como objetivo describir y analizar la formación de un Complejo Convectivo de Mesoescala (CCM) en el Perú, usando las salidas del modelo regional Eta/SENAMHI. Para la formación de éste CCM se presentó una vaguada de onda corta del este en niveles medios y la Corriente en Chorro de bajos Niveles del Sur (SJ; siglas en ingles) que fue incentivado por la incursión de una Alta migratoria en continente generando vientos con escasa humedad desde las Pampas de Argentinas, desplazándose por las zonas bajas de Paraguay, selva de Bolivia e incursionando por la selva sur del Perú, que al encontrarse con las masas de aire cálido y húmedo procedentes de la Hoya Amazónica originó convergencia en bajos niveles dando lugar a la formación de nubosidad de gran desarrollo vertical en la selva Sur.
Propuesta de operación del sistema de riego regulado del proyecto Majes-Siguas
Authors: Huanca V. Leandro , Sánchez D. Miguel
Published: April 2024

En el presente, ubicado en la Región Arequipa, es el Proyecto Especial de Irrigación más importante de la región y fue diseñado para una superficie agrícola de 57 000 ha. Es dividido en dos etapas: la Primera comprendió la construcción de la represa Condoroma y el sistema de conducción y construcción de canales de la Irrigación de las Pampas de Majes, teniendo como fin incorporar 23 000 ha. En la Segunda Etapa se ha proyectado la construcción de la represa Angostura y las centrales hidroeléctricas de Lluclla y Lluta, que permitirá la ampliación de la superficie agrícola hasta 57 000 ha. Dado el crecimiento poblacional, es necesario hacer continuamente la actualización de las ofertas y de las demandas de los recursos hídricos para diversos usos. Es así, que en el presente estudio, se determinaron las disponibilidades al 75% y 95% de persistencia en las estaciones de Condoroma, Tuti y Pitay, cuyos valores fueron 2.70, 3.79 y 2.37 m3/seg respectivamente, y, al 95% fueron de 1.56, 2.24 y 1.59 m3/seg. Respectivamente. En cuanto a las demandas, se calcularon utilizando los hidromódulos de 0.57, 0.60, 0.70 y 0.75 l/seg-ha., siendo estas de 11.930, 12.558, 14.651 y 15.697 m3/seg. respectivamente. Asimismo, se realizó la simulación de Operación del Sistema del Proyecto Majes-Siguas en su Primera Etapa con la ayuda del programa HEC-3, para un periodo de 42 años. Se han analizado diversas alternativas para cada uno de los escenarios definidos por cada hidromódulo de riego, a fin de determinar el valor de la demanda que condicione la operación del sistema de acuerdo a criterios preestablecidos. De la simulación llevada a cabo, se demuestra que los valores de las demandas de riego de las 20 930 ha para la Primera Etapa, pueden ser atendidas sin mayor problema con una persistencia en tiempo mayor al 78 %, no así al considerar los criterios de déficits del Water and Power Resources que da resultados conservadores, toda vez que de acuerdo a los hidromódulos de riego de 0.57, 0.60, 0.70 y 0.75 l/sha, se podrían irrigar 16,580; 15,750; 13,500 y 12,600 ha respectivamente en las Pampas de Majes.
Avaliação dos pós-graduandos sobre o programa de aperfeiçoamento de ensino no período de 2020 a 2021
Authors: Marques Marina , Nakano Mônica Mitsue , Dias Maraina Gomes Pires Fernandes , Silva Débora Tatiane Góes , Andrade Luciane Sá de , Gonçalves Marlene Fagundes Carvalho
Published: April 2024

O objetivo deste artigo foi analisar o Programa de Aperfeiçoamento de Ensino da Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo no Brasil sobre a formação docente promovida no período de 2020 a 2021. O instrumento utilizado para obtenção dos dados se constituiu de questionários eletrônicos com questões objetivas e dissertativas aplicados semestralmente aos estagiários do Programa. Realizou-se a análise temática proposta por Braun e Clarke. O total de respondentes foi de 144 pós-graduandos. O período pesquisado foi perpassado pela pandemia da COVID-19 e pode-se dizer que a necessidade de adaptação e inovação às novas tecnologias de ensino remoto trouxe avanços no processo de formação docente. Destacou-se ainda que os estagiários puderam vivenciar, em sua formação, as cinco dimensões da docência, o que foi avaliado como uma experiência muito satisfatória.
Revolutionizing Wound Healing: Unleashing Nanostructured Lipid Carriers Embodied with Herbal Medicinal Plant
Authors: Jain Aditya , Yadav Shikha , Khan Javed
Published: April 2024

Wound healing is crucial for maintaining skin integrity and preventing complications
from external threats. Various plants, such as Achillea millefolium, Aloe vera, Curcuma longa,
Calendula officinalis, Camellia sinensis, Azadirachta indica, and Plantago, have demonstrated
wound healing capabilities and have been used in herbal medicine for wound care. NLCs are
second-generation lipid nanoparticles, blending solid and liquid lipids to improve medication
loading and limit leakage. NLCs have been used in various applications, including cosmeceuticals,
chemotherapy, gene therapy, and brain targeting. Wound healing is divided into four stages:
hemostasis, inflammatory response, proliferation, and remodeling. Factors such as age, gender,
chronic disorders, and local agents like infections can affect recovery. These plants' antiinflammatory,
antioxidant, and antibacterial activities have demonstrated potential in wound
healing. Combining herbal medicinal plants and nanostructured lipid carriers (NLCs) can revolutionise
wound treatment and improve overall healthcare outcomes.
A Comprehensive Review on Nanoparticles as Drug Delivery System and Their Role for Management of Hypertension
Authors: Prerna  , Bhatt Dinesh Chandra , Mir Khalid Basir , Kumar Vikash , Rathor Sandeep
Published: April 2024

The current global epidemic of hypertension is not a disease in and of itself but rather
a significant risk factor for serious cardiovascular conditions such as peripheral artery disease,
heart failure, myocardial infarction, and stroke. Although many medications that work through
various mechanisms of action are available on the market in conventional formulations to treat
hypertension, these medications face significant difficulties with their bioavailability, dosing,
and associated side effects, which significantly reduces the effectiveness of their therapeutic
interventions. Numerous studies have shown that nanocarriers and nanoformulations can minimize
the toxicity associated with high doses of the drug while greatly increasing the drug's bioavailability
and reducing the frequency of dosing.

This review sheds light on the difficulties posed by traditional antihypertensive formulations and
highlights the necessity of oral nanoparticulate systems to solve these issues. Because hypertension
has a circadian blood pressure pattern, chronotherapeutics can be very important in treating
the condition. On the other hand, nanoparticulate systems can be very important in managing
hypertension.
Evaluation and Characterization of Modified K114 Method to Localize
Plaques in Rodent and Plaques and Tangles in Human Brain Tissue
Authors: Padala Sanjana , Setti Sharay , Raymick James , Hanig Joseph , Sarkar Sumit
Published: April 2024

Background:

A plethora of studies has shown the utility of several chemical dyes due
to their affinity to bind Aβ to enable visualization of plaques under light or fluorescence microscope,
and some of them showed affinity to bind neurofibrillary tangles (NFT) as well. However,
only a few of them have the propensity to bind both senile plaques (SP) and NFT simultaneously.

Objective:

In our current study, we aimed to modify the K114 dye and the staining procedure to
substantially improve the staining of amyloid plaques in both human and rodent brains and neurofibrillary
tangles in the human brain

Methods:

We modified the K114 solution and the staining procedure using Sudan Black as a modifier.
Additionally, to evaluate the target of the modified K114, we performed double labeling of
K114 and increased Aβ against three different epitopes. We used 5 different antibodies to detect
phosphorylated tau to understand the specific targets that modified K114 binds.

method:

We have modified the K114 solution and the staining procedure using Sudan Black as modifier. Additionally, to evaluate the target of the modified K114, we performed double labeling of K114, and Aβ raised against three different epitopes. We used 5 different antibodies to detect phosphorylated Tau to understand the potential binding targets.

Results:

Dual labeling using hyperphosphorylated antibodies against AT8, pTau, and TNT1 revealed
that more than 80% hyperphosphorylated tau colocalized with tangles that were positive
for modified K114, whereas more than 70% of the hyperphosphorylated tau colocalized with modified
K114. On the other hand, more than 80% of the plaques that were stained with Aβ MOAB-2
were colocalized with modified K114.

result:

We have found more than 80% hyperphosphorylated Tau against AT8, PTau and TNT1 colocalized with K114 labeled tangles, whereas more than 70% of the hyperphosphorylated Tau colocalized with modified K114. On the other hand, more than 80% of the plaques that were stained with amyloid beta MOAB-2 were colocalized with modified K114.

Conclusion:

Our modified method can label amyloid plaques within 5 min in the rat brain and
within 20 min in the human brain. Our results indicated that modified K114 could be used as a
valuable tool for detecting amyloid plaques and tangles with high contrast and resolution relative
to other conventional fluorescence markers.
Development and Characterization of Imatinib Mesylate Liposome: For
In-vitro Anti-cancer Activity
Authors: Patil Pravin , Choudhary Manju , Sankpal Poournima , Patil Sachinkumar , Gadad Anand
Published: April 2024

Introduction:

According to our research, liposomes loaded with imatinib mesylate were
formulated using a rotary evaporator and the thin film hydration method. FTIR, DSC, and XRD studies
were carried out to ensure that the drug excipients in the final formulation were compatible.

Method:

The improved liposome batch (F7) was tested for particle size (353.9 nm), zeta potential (-
46.0 mV), drug release (92.8%), and entrapment efficiency (94.29%) after 72 hours. Studies using
TEM have shown that imatinib mesylate-loaded liposomes have a spherical form.

Result:

Finally, in-vitro anticancer activity was assessed through the MTT assay, which revealed an
IC50 value of 0.2959μg mL-1 for treating Human leukaemia monocytic cell lines.

Conclusion:

The process was refined based on data concerning the rotary evaporator speed, solvent
system ratio and volume, hydration media pH, manufacturing yield, entrapment efficiency, in-vitro
release, and improved in vitro anti-cancer activity.
The Implementation of Space Vector PWM in 36-Pulse D-STATCOM for Power Quality Improvement
Authors: Bandopadhyay Subhasis , Banerjee Atanu , Mondal Ashoke
Published: April 2024

Introduction:

This paper addresses the ongoing challenge of harmonics reduction in
power systems, particularly focusing on Flexible AC Transmission Systems (FACTS) devices.
Instead of employing a conventional multilevel converter, an alternative configuration is proposed:
a 36-pulse gate turn-off thyristor-based converter (GTO-VSC). This converter comprises
three 12-pulse Voltage Source Converters (VSCs) as fundamental units, operating collectively on
the frequency mode of GTO switching control within a Distribution Static Synchronous Compensator
(D-STATCOM). The D-STATCOM dynamically compensates reactive power in the system.
The 36-pulse configuration results in AC output voltage waveforms containing harmonics such as
the 35th, 37th, 71st, 73rd, etc., leading to higher total harmonic distortion (THD) levels.

background:

Reduced number of switches in flexible AC transmission.

Method:

In response, the paper presents a new model featuring a 3-level, 36-pulse, 25kV,
±3MVAr STATCOM configured with 12-pulse GTO-VSCs. This model incorporates PWM gate
switching and employs a PI-control methodology to optimize harmonics in simulation, specifically
targeting harmonics at the 35th, 37th, 71st, 73rd, etc., orders using Sim Power Systems toolbox in
Math Works software.

Result:

The compensator's operational performance is controlled through switching angle optimization,
which minimizes harmonics, regulates voltage, and manages reactive power in the electrical
transmission system.

Conclusion:

The simulation results demonstrate that the proposed model is acceptable for enhancing
the flexibility and performance of the FACTS device in mitigating harmonics in power systems.
The Influence of Service Quality on Consumer Satisfaction and Purchase Intention at The Legendary Restaurants in Malang
Authors: Andriyani Dwi Retno
Published: April 2024

The high-quality service is provided for customers to achieve customer’s satisfaction goals which actually could be mediated by their emotion. Therefore, to increase the customer satisfaction, the company need to pay attention to the quality service that is provided to add the positive emotions and reduce negative emotion. Consumer satisfaction also has an impact on customer loyalty that affects business development in the future. The customer satisfaction also has an impact on customer loyalty that affects the business development in the future. Similarly, the legendary restaurant nowadays has to survive in this onslaught era with many modern restaurants are emerging. Thus, it is necessary to improve the quality service in the terms of product quality, service providing, and the restaurant’s atmosphere. This research analyzed using SEM-PLS method by analyzing the tools used in WarpPLS. The result found that quality service has a positive impact on the positive emotions of the customers. It is compared If the quality service has a negative impact, it causes negative emotions also. So that, it could be guaranteed that the provided quality service succeeded in building positive emotions in customers. The positive emotions that experienced by the customers automatically defined their satisfaction and that thing also indirectly drive them to become a loyal customer. The Influence of Service Quality on Consumer Satisfaction and Purchase Intention at The Legendary.
Urinary dysfunction in multiple sclerosis
Authors: Abdallax Nemer M.N. , Belousov I. I. , Goncharova Z. A. , Ismailov R. S. , Rudenko O. Yu. , Pchelkin A. S.
Published: April 2024

This review presents the relevance of mandatory assessment of the function of the lower urinary tract in multiple sclerosis to identify the lower urinary tract symptoms, the nature and severity of disability in patients regarding urinary disorders. Lower urinary tract symptoms in multiple sclerosis are diverse and correlate with the phases of the urination cycle. lower urinary tract symptoms in multiple sclerosis include urinary urgency or sporadic episodes of urinary retention. As the disease progresses, along with urgency and sensory disturbances, urinary incontinence develops, resulting in total urinary incontinence in the most severe cases. Chronic urine retention may also form, which determines the need to urine diversion from the bladder through urethral drainage. In turn, the risk of developing urinary tract infections, including catheter-associated ones, increases significantly.
Prognostic influence of fibroblast growth factor 23 on the course of coronary heart disease in patients with chronic kidney disease
Authors: Samakaev A. S. , Glova S. E. , Khaisheva L. A. , Lapushkina M. A. , Shlyk S. V.
Published: April 2024

Objective: to study the prognostic impact of the level of fibroblast growth factors 23 on coronary heart disease depending on the stage of chronic kidney disease. Materials and methods:  the study included 108 patients with coronary heart disease (CHD), stable angina (stress), functional class 1–3, chronic kidney disease (CKD) C1–C4, average age was 67,62±12,51 years (55 men and 53 women). The level of fibroblast growth factor 23 was assessed using the Biomedica FGF 23 multimatrix enzyme-linked immunosorbent assay. After 12 months of follow-up, the presence of a cumulative endpoint including the occurrence of acute coronary syndrome, stroke, transient ischemic attack, heart failure and death. Differences in data and correlations between them were considered statistically significant at p<0.05. Results: the developed prognostic model to determine the likelihood of cardiovascular complications in patients with coronary artery disease and CKD found that the FGF 23 level is equal to 27.9 with a sensitivity of 62.7% and specificity of 62.5% to distinguish patients with ischemic heart disease and CKD in whom a cumulative endpoint will occur over 12 months of follow-up. Conclusions: to identify patients at high risk of cardiovascular complications in coronary artery disease and CKD, it is advisable to use determination of FGF 23 level.
Association of iron metabolism with erythrocyte parameters, myeloid and lymphoid cells in patients with sleep disorders
Authors: Ivaschenko A. A. , Kalinkin A. L.
Published: April 2024

Objective: to identify the relationship between the main indicators of iron metabolism and erythrocyte parameters, myeloid and lymphoid cells in patients with sleep disorders in patients with sleep disorders (obstructive sleep apnea (OSA), chronic insomnia (CI), restless legs syndrome (RLS)). Materials and methods: 118 patients, 60 men (50.8%) and 58 women (49.2%), Me age — 47 years (Q1–Q3: 35–61), Me BMI — 25.81 kg/m2 (Q1–Q3: 22.72–29.40) with obstructive sleep apnea (OSA), chronic insomnia, restless legs syndrome in their various combinations.  All patients underwent a polysomnographic study, blood cell count, biochemical parameters of iron metabolism were assessed. Results: when assessing the relationship between “Ferritin” and “Hemoglobin”, “Hematocrit (%)”, “Erythrocytes”, “Lymphocytes, abs.”, a moderate direct relationship was established (p<0.001; p<0.001; p=0.001; p< 0.013, respectively).When assessing the relationship between  “RDW (%)”, “Neutrophils total, %”, “Neutrophils, abs.” and “%TS”, a moderate inverse relationship was established (p=0.026; p=0.028; p =0.01, respectively).When assessing the relationship between “RDW (%)”, “Neutrophils total, %” and “Serum iron”, a moderate inverse relationship was established (p = 0.003; p = 0.012, respectively). When assessing the relationship between “Lymphocytes, %” and “Serum iron”, a weak direct relationship was established (p = 0.049). Conclusions: in patients with sleep disorders, a statistically significant relationship was revealed between the main parameters of iron metabolism and indicators of “red” blood, the content of neutrophils and lymphocytes. It was shown for the first time that in patients with sleep disorders, changes in the content of neutrophils and lymphocytes may be associated not only with changes in sleep itself, but also with the state of iron metabolism. The complex relationships of iron metabolism, the function of erythrocytes, neutrophils and lymphocytes in patients with sleep disorders can affect the development of both infectious and non-infectious diseases through the mechanisms of maintaining chronic inflammation, hypoferemia, ferroptosis, netosis and other mechanisms.
Ventricular arrhythmias in patients with chronic heart failure and central sleep apnea with Cheyne-Stokes respiration
Authors: Seredenina E. M. , Krasilnikova E. S. , Kalinkin A. L.
Published: April 2024

The review is devoted to the influence of central sleep apnea and Cheyne-Stokes breathing on the prognosis of patients with chronic heart failure. The connection between sleep breathing disorders and an increased risk of ventricular arrhythmias and the mechanisms of these interactions are discussed, and options for approaches to therapy are considered.
Acupuncture in Oncology – Update 2024
Authors: Litscher Gerhard
Published: April 2024

Acupuncture, as a promising complementary therapy for cancer patients, offers personalized symptom management and improved quality of life alongside conventional treatments. With its proven efficacy in alleviating chemotherapy-induced side effects such as nausea, fatigue, and pain, acupuncture stands as a holistic approach to cancer care. Tailored to individual needs and boasting a favorable safety profile, acupuncture addresses both physical symptoms and psychological distress, promoting resilience and quality of life. By integrating specific acupuncture points into treatment protocols, practitioners can provide targeted relief and support for patients, fostering holistic healing and emotional well-being amidst the challenges of cancer treatment.
Global Ocean Forecast Accuracy Improvement Due to Optimal Sensor Placement
Authors: Turko Nikita , Lobashev Aleksandr , Ushakov Konstantin , Kaurkin Maksim , Kal'nickiy Leonid , Semin Sergey , Ibraev Rashit
Published: April 2024

The paper examines the impact of sensor placement on the accuracy of the Global ocean state forecasting. A comparison is made between various sensor placement methods, including the arrangement obtained by the Concrete Autoencoder method. To evaluate how sensor placement affects forecast accuracy, a simulation was conducted that emulates a scenario where the initial state of the global ocean significantly deviates from the ground truth. In the experiment, initial conditions for the ocean and ice model were altered, while atmospheric forcing was retained from the control experiment. Subsequently, the model was integrated with the assimilation of data about the ground truth state at the sensor locations. The results showed that the sensor placement obtained using deep learning methods is superior in forecast accuracy to other considered arrays with a comparable number of sensors.