bluuebunny/crossref_metadata_2025 huggingface dataset:
Young adult mental health and functional outcomes among individuals with remitted, persistent and late-onset ADHD
Authors: Agnew-Blais Jessica C. , Polanczyk Guilherme V. , Danese Andrea , Wertz Jasmin , Moffitt Terrie E. , Arseneault Louise
Published: June 2018

Background

Attention-deficit hyperactivity disorder (ADHD) is associated with mental health problems and functional impairment across many domains. However, how the longitudinal course of ADHD affects later functioning remains unclear.

Aims

We aimed to disentangle how ADHD developmental patterns are associated with young adult functioning.

Method

The Environmental Risk (E-Risk) Longitudinal Twin Study is a population-based cohort of 2232 twins born in England and Wales in 1994–1995. We assessed ADHD in childhood at ages 5, 7, 10 and 12 years and in young adulthood at age 18 years. We examined three developmental patterns of ADHD from childhood to young adulthood – remitted, persistent and late-onset ADHD – and compared these groups with one another and with non-ADHD controls on functioning at age 18 years. We additionally tested whether group differences were attributable to childhood IQ, childhood conduct disorder or familial factors shared between twins.

Results

Compared with individuals without ADHD, those with remitted ADHD showed poorer physical health and socioeconomic outcomes in young adulthood. Individuals with persistent or late-onset ADHD showed poorer functioning across all domains, including mental health, substance misuse, psychosocial, physical health and socioeconomic outcomes. Overall, these associations were not explained by childhood IQ, childhood conduct disorder or shared familial factors.

Conclusions

Long-term associations of childhood ADHD with adverse physical health and socioeconomic outcomes underscore the need for early intervention. Young adult ADHD showed stronger associations with poorer mental health, substance misuse and psychosocial outcomes, emphasising the importance of identifying and treating adults with ADHD.

Declaration of interest

None.
GH Therapy in Childhood Cancer Survivors: A Systematic Review and Meta-Analysis
Authors: Tamhane Shrikant , Sfeir Jad G , Kittah Nana Esi N , Jasim Sina , Chemaitilly Wassim , Cohen Laurie E , Murad M Hassan
Published: June 2018

Background

GH deficiency (GHD) is common among childhood cancer survivors (CCSs) with history of tumors, surgery, and/or radiotherapy involving the hypothalamus-pituitary region. We aimed to evaluate the effects of GH therapy (GHT) in CCSs on adult height, risk of diabetes mellitus, abnormal lipids, metabolic syndrome, quality of life, secondary tumors, and disease recurrence.

Methods

We searched multiple databases for randomized and observational studies. Pairs of reviewers independently selected studies and collected data. Random effects meta-analysis was used to pool outcomes across the studies.

Results

We included 29 observational studies at moderate to high risk of bias. Sixteen studies compared CCSs on GHT with those not on GHT (512 patients, GH dose: 0.3 to 0.9 IU/kg/week). GHT was significantly associated with height gain [standard deviation score, 0.61; 95% CI, 0.08 to 1.13] and was not significantly associated with the occurrence of secondary tumors [odds ratio (OR), 1.10; 95% CI, 0.72 to 1.67] or tumor recurrence (OR, 0.57; 95% CI, 0.31 to 1.02). Thirteen studies compared CCSs on GHT with normal age- or sex-matched controls or controls with idiopathic GHD or short stature. GHT was associated with either improved or unchanged risk of diabetes, lipid profiles, and metabolic syndrome. GHT was associated with improvements in quality of life.

Conclusion

CCSs treated with GHT gain height compared with the untreated controls. GHT may improve lipid profiles and quality of life and does not appear to increase the risk of diabetes or the development of secondary tumors, although close monitoring for such complications remains warranted due to uncertainty in the current evidence.
Emergency Manual Implementation in a Large Academic Anesthesia Practice: Strategy and Improvement in Performance on Critical Steps
Authors: Gleich Stephen J. , Pearson Amy C. S. , Lindeen Kevin C. , Hofer Ryan E. , Gilkey George D. , Borst Luann F. , Haile Dawit T. , Martin David P.
Published: June 2018

BACKGROUND:

The use of cognitive aids, such as emergency manuals (EMs), improves team performance on critical steps during crisis events. In our large academic anesthesia practice, we sought to broadly implement an EM and subsequently evaluate team member performance on critical steps.

METHODS:

We observed the phases of implementing an EM at a large academic anesthesia practice from 2013 to 2016, including the formation of the EM implementation team, identification of preferred EM characteristics, consideration of institution-specific factors, selection of the preferred EM, recognition of logistical barriers, and staff education. Utilization of the EM was tested in a regular clinical environment with all available resources using a standardized verbal simulation of 3 crisis events both preimplementation and 6 months postimplementation. Individual members of the anesthesia team were asked to verbalize interventions for specific crisis events over 60 seconds.

RESULTS:

We introduced a customized version of the Stanford Emergency Manual on January 26, 2015. Fifty-nine total participants (equal proportion of anesthesiology attending physicians, resident physicians, certified registered nurse anesthetists, and student registered nurse anesthetist staff) were surveyed in the preimplementation phase and 60 in the 6-month postimplementation phase. In the postimplementation phase, a minority (41.7%) utilized the EM for the verbal-simulated crisis events. Those who used the EM performed better than those who did not (median 21.0 critical steps out of a possible 30 total steps [70.0%], interquartile range 19–25 vs 18.0 critical steps verbalized [60.0%], interquartile range 16–20; P < .001). Among all subjects, the median number of critical steps verbalized was 16 (53.3%) preimplementation and 19.5 critical steps (65.0%) postimplementation.

CONCLUSIONS:

Implementation of an EM in a large academic anesthesia practice is not without challenges. While full integration of the EM was not achieved 6 months after implementation, verbalization of critical steps on 3 simulated crisis events improved when the EM was utilized.
Cervical Spine Motion During Tracheal Intubation Using an Optiscope Versus the McGrath Videolaryngoscope in Patients With Simulated Cervical Immobilization: A Prospective Randomized Crossover Study
Authors: Nam Karam , Lee Younsuk , Park Hee-Pyoung , Chung Jaeyeon , Yoon Hyun-Kyu , Kim Tae Kyong
Published: June 2018

BACKGROUND:

In patients with an unstable cervical spine, maintenance of cervical immobilization during tracheal intubation is important. In McGrath videolaryngoscopic intubation, lifting of the blade to raise the epiglottis is needed to visualize the glottis, but in patients with an unstable cervical spine, this can cause cervical spine movement. By contrast, the Optiscope, a rigid video-stylet, does not require raising of the epiglottis during tracheal intubation. We therefore hypothesized that the Optiscope would produce less cervical spine movement than the McGrath videolaryngoscope during tracheal intubation. The aim of this study was to compare the Optiscope with the McGrath videolaryngoscope with respect to cervical spine motion during intubation in patients with simulated cervical immobilization.

METHODS:

The primary outcome of the study was the extent of cervical spine motion at the occiput–C1, C1–C2, and C2–C5 segments. In this randomized crossover study, the cervical spine angle was measured before and during tracheal intubation using either the Optiscope or the McGrath videolaryngoscope in 21 patients with simulated cervical immobilization. Cervical spine motion was defined as the change in angle at each cervical segment during tracheal intubation.

RESULTS:

There was significantly less cervical spine motion at the occiput–C1 segment using the Optiscope rather than the McGrath videolaryngoscope (mean [98.33% CI]: 4.7° [2.4–7.0] vs 10.4° [8.1–12.7]; mean difference [98.33% CI]: −5.7° [−7.5 to −3.9]). There were also fewer cervical spinal motions at the C1–C2 and C2–C5 segments using the Optiscope (mean difference versus the McGrath videolaryngoscope [98.33% CI]: −2.4° [−3.7 to −1.2]) and −3.7° [−5.9 to −1.4], respectively).

CONCLUSIONS:

The Optiscope produces less cervical spine motion than the McGrath videolaryngoscope during tracheal intubation of patients with simulated cervical immobilization.
MODELO PARA ESTUDO DE NEGÓCIOS SOCIAIS À LUZ DA PSICODINÂMICA DO TRABALHO: METODOLOGIA QUALITATIVA PARA PESQUISAS SOBRE VIVÊNCIAS EM ORGANIZAÇÕES DE IMPACTO SOCIAL
Authors: Alves Diana Maria Goiana , Santos Ana Cristina Batista dos
Published: June 2018

O artigo apresenta uma proposta metodológica qualitativa para estudo do construto Negócio Social à luz da Psicodinâmica do Trabalho. Parte da identificação de uma variedade não consensual de conceitos que envolvem os Negócios Sociais e os estuda pelas lentes da Psicodinâmica do Trabalho, considerando as dimensões de contexto (condições de trabalho, organização do trabalho, relações de trabalho) e de conteúdo (carga psíquica, prazer-sofrimento, estratégias de defesa) dessa teoria. O objetivo do artigo é propor um framework metodológico para pesquisas qualitativas em Psicodinâmica do Trabalho, considerando as especificidades dos Negócios Sociais. Apresenta uma proposta de campo baseada na entrevista narrativa, de natureza exploratória, com uso de tópicos-guia centrados na tríade vivências, pensamento, sentimento; utilização de elementos-estímulo como ferramenta projetiva; e a análise dos núcleos de sentido como técnica de análise. O artigo contribui com a área dos métodos qualitativos, ao exemplificar uma espécie de “projeto de artesanato metodológico”, ao mesmo tempo “customizável” e replicável, para pesquisas que consideram a indissociável relação teoria-objeto-método.
A RIQUEZA DAS FAVELAS, O PODER ECONÔMICO DA MULTIDÃO ESCONDIDO ENTRE MORROS E VIELAS: UMA ANÁLISE COMPARATIVA ENTRE OS EMPREENDEDORES DAS MAIORES FAVELAS DO BRASIL E DA ARGENTINA – ROCINHA E VILLA 31
Authors: Lima Vinicius Mendes
Published: June 2018

O presente ensaio tem por objetivo analisar e compreender o modo e como o micro e pequenos empreendedores das principais favelas dos países estudados utilizam os conceitos teóricos da administração e do marketing, no desenvolvimento de seus empreendimentos. A pesquisa ocorre na Villa 31, cidade de Buenos Aires, Argentina e, na comunidade da Rocinha, cidade do Rio de Janeiro, Brasil, entrelaçando temas ao longo do estudo que passam de favelas ao empreendedorismo de micro e pequenas empresas até políticas públicas existentes para tal setor. A evolução do conceito de empreendedorismo, bem como o crescimento das favelas, tornou as políticas públicas cada vez menos eficazes. Dessa forma, o papel do marketing se torna essencial para o possível crescimento dos empreendimentos dentro destas favelas.
A COMERCIALIZAÇÃO DOS RESÍDUOS SÓLIDOS URBANOS: O CASO DE CAMURUM
Authors: Lima Mirian Assumpção , Paula Helton Cristian de , Amorim Rômulo Perentoni
Published: June 2018

O caso relata uma situação real sobre a comercialização de resíduos sólidos urbanos (RSU) em um município mineiro de pequeno porte. O processo de transição de um lixão para uma usina de triagem e compostagem (UTC) motivou uma disputa de interesses entre uma empresa, que pretendia se instalar na região, os comerciantes locais e os catadores que atuavam no lixão. Essa concorrência incentivou o secretário de Administração analisar as variáveis intervenientes na comercialização dos RSU municipais e a saída encontrada foi inusitada. Este caso de ensino pode ser utilizado para discussão, em especial da legislação, de temas relacionados à gestão de resíduos sólidos urbanos, principalmente no tocante à comercialização dos RSU e, a licitação e contratos que enfocam as modalidades de licitação que podem ser empregadas nesse processo.
Apresentação - Ciclo de Debates
Authors: Andrade Raphael De J. Campos de , Coelho Arnaldo F. Matos , Weersma Laodicéia Amorim
Published: June 2018

A ciência passou a se desenvolver exponencialmente a partir do momento em que os EUA atribuíram ao conhecimento o mérito de terem ganho a Segunda Guerra Mundial. Do mesmo modo, no âmbito das organizações, “A gestão científica ganhou um impulso extraordinário a partir da atribuição do êxito dos EUA na Segunda Guerra Mundial à boa gestão em grandes corporações.” (FARIA, 2011, p. 1165). Pode-se, ainda, argumentar que, durante a Guerra Fria, a gestão científica se disseminou para diversos outros países, entre eles o Brasil, “com o intuito de proteger o ‘mundo livre’ da ameaça comunista.” (ALCADIPANI; BERTERO, 2012, p. 289).
INCORPORAÇÃO DA BIOMIMÉTICA NA GESTÃO DE PROJETOS DE INOVAÇÃO TECNOLÓGICA: ANÁLISE DE UMA EXPERIÊNCIA CORPORATIVA
Authors: Vilha Anapatrícia Morales , Cecotte Mariana
Published: June 2018

A biomimética compreende a área que estuda os princípios criativos e estratégias da natureza, visando à criação de soluções para os problemas e necessidades da humanidade, unindo funcionalidade, estética e sustentabilidade. Vários trabalhos científicos apontam para o desenvolvimento de inovações tecnológicas a partir da inspiração dos fenômenos biológicos para o desenvolvimento de produtos. Para a compreensão deste processo, o trabalho apresentou o estudo de caso da empresa Festo do Brasil, realizado a partir de entrevistas presenciais nos meses de junho e julho de 2017 com gerentes das áreas de Pesquisa e Desenvolvimento (P&D) e Novos Negócios. Os dados obtidos por entrevista foram complementados pelo acesso aos materiais institucionais fornecidos pela empresa. Por meio do estudo de caso, foi possível constatar que a empresa iniciou o desenvolvimento de projetos biomiméticos no ano de 2006, em sua unidade sede, localizada na Alemanha. A área de Pesquisa e Desenvolvimento (P&D) pode ser destacada como vértice central desse sistema, posto que esse setor influenciou ativamente o processo de inovação tecnológica das empresas e domina o estado da arte das novas tecnologias. Além disso, a criação de parcerias com universidades e pesquisadores foi de grande valia para potencializar o conhecimento sobre o biomimetismo a partir de bases científicas. Não obstante, para internalizar a prática da biomimética nas organizações, é indispensável que já haja na empresa um processo sistemático de gestão de inovação vigente, dado que a abordagem do biomimetismo exige uma estrutura tecnológica e organizacional adensada e requer altos investimentos em pesquisa, desenvolvimento e adaptação dos aparatos de produção, cujos ciclos de desenvolvimento se mostram mais extensivos do que se comparados aos ciclos de desenvolvimento de produtos sem a abordagem biomimética presente.
Editorial
Authors: Shintaku Milton , Coelho Arnaldo F. Matos , Weersma Laodicéia Amorim
Published: June 2018

Gestão é um termo múltiplo, que transcende às tentativas de classificá-lo em uma única disciplina. Isto pode ser notado pela representatividade da Revista de Gestão em Análise (ReGeA), com avaliação Qualis em mais quatro disciplinas, além do principal escopo do periódico, a Administração. Ressalta-se a visibilidade que esta revista possui, sendo um canal de disseminação de conhecimento de temas abrangentes e necessário ao desenvolvimento técnico e científico do país. [...]
ΕΠΙ ΤΗΣ ΚΕΤΩΣΕΩΣ ΤΩΝ ΓΑΛΑΚΤΟΦΟΡΩΝ ΑΓΕΛΑΔΩΝ
Authors: ΚΑΡΔΑΣΗΣ Ι.
Published: June 2018

NO ABSTRACT AVAILABLE
LA PREVENTION DES MALADIES INFECTIEUSES DES ANIMAUX DOMESTIQUES ET DE L'HOMME AU MOYEN DES VACCINS
Authors: RAMON G.
Published: June 2018

NO ABSTRACT AVAILABLE
Ο ΠΡΟΛΗΠΤΙΚΟΣ ΕΜΒΟΛΙΑΣΜΟΣ ΕΙΣ ΤΟΝ ΑΓΩΝΑ ΕΝΑΝΤΙΟΝ ΤΟΥ ΑΦΘΩΔΟΥΣ ΠΥΡΕΤΟΥ ΠΑΡΑΤΗΡΗΣΕΙΣ ΓΕΝΟΜΕΝΑΙ ΕΝ ΒΕΛΓΙΩ
Authors: WILLEMS RENE , LEUNEN JOSEPH
Published: June 2018

NO ABSTRACT AVAILABLE
ΕΠΙ ΤΗΣ ΚΕΤΩΣΕΩΣ ΤΩΝ ΓΑΛΑΚΤΟΦΟΡΩΝ ΑΓΕΛΑΔΩΝ III. ΑΙΤΙΟΛΟΓΙΑ
Authors: ΚΑΡΔΑΣΗΣ Ι.
Published: June 2018

NO ABSTRACT AVAILABLE
ΤΟ ΠΡΟΒΛΗΜΑ ΤΗΣ ΣΤΕΙΡΟΤΗΤΟΣ ΤΩΝ ΒΟΟΕΙΔΩΝ
Authors: ΔΗΜΗΤΡΟΠΟΥΛΟΣ Ε.
Published: June 2018

NO ABSTRACT AVAILABLE
Enterobacter hormaechei subsp. hoffmannii subsp. nov., Enterobacter hormaechei subsp. xiangfangensis comb. nov., Enterobacter roggenkampii sp. nov., and Enterobacter muelleri is a later heterotypic synonym of Enterobacter asburiae based on computational analysis of sequenced Enterobacter genomes.
Authors: Sutton Granger G. , Brinkac Lauren M. , Clarke Thomas H. , Fouts Derrick E.
Published: June 2018

Background: The predominant species in clinical Enterobacter isolates is E. hormaechei. Many articles, clinicians, and GenBank submissions misname these strains as E. cloacae. The lack of sequenced type strains or named species/subspecies for some clades in the E. cloacae complex complicate the issue.

Methods: The genomes of the type strains for Enterobacter hormaechei subsp. oharae, E. hormaechei subsp. steigerwaltii, and E. xiangfangensis, and two strains from Hoffmann clusters III and IV of the E. cloacae complex were sequenced. These genomes, the E. hormaechei subsp. hormaechei type strain, and other available Enterobacter type strains were analysed in conjunction with all extant Enterobacter genomes in NCBI’s RefSeq using Average Nucleotide Identity (ANI).

Results: There were five recognizable subspecies of E. hormaechei: E. hormaechei subsp. hoffmannii subsp. nov., E. hormaechei subsp. xiangfangensis comb. nov., and the three previously known subspecies. One of the strains sequenced from the E. cloacae complex was not a novel E. hormaechei subspecies but rather a member of a clade of a novel species: E. roggenkampii sp. nov.. E. muelleri was determined to be a later heterotypic synonym of E. asburiae which should take precedence.

Conclusion: The phylogeny of the Enterobacter genus, particularly the cloacae complex, was re-evaluated based on the type strain genome sequences and all other available Enterobacter genomes in RefSeq.
Ten considerations for open peer review
Authors: Schmidt Birgit , Ross-Hellauer Tony , van Edig Xenia , Moylan Elizabeth C
Published: June 2018

Open peer review (OPR), as with other elements of open science and open research, is on the rise. It aims to bring greater transparency and participation to formal and informal peer review processes. But what is meant by `open peer review', and what advantages and disadvantages does it have over standard forms of review? How do authors or reviewers approach OPR? And what pitfalls and opportunities should you look out for? Here, we propose ten considerations for OPR, drawing on discussions with authors, reviewers, editors, publishers and librarians, and provide a pragmatic, hands-on introduction to these issues. We cover basic principles and summarise best practices, indicating how to use OPR to achieve best value and mutual benefits for all stakeholders and the wider research community.
Comparative statistical analysis of neutral wind in mid-latitude mesosphere / lower thermosphere based on meteor radar and Fabry — Perot interferome-ter data
Authors: Васильев Роман , Vasilyev Roman , Артамонов Максим , Artamonov Maksim , Мерзляков Евгений , Merzlyakov Evgeniy
Published: June 2018

Studies of the upper atmosphere wind are very important both for understanding the mechanism of transformation of exposure energy into heating, movement and chemical activity of the atmosphere, and similar processes of energy transfer from lower to upper atmospheric layers. Instruments and methods for studying the wind velocity and its variations at different height levels usually complement each other in such studies. We perform a comparative analysis of information about the neutral horizontal wind over Eastern Siberia in the winter-spring period obtained by different methods. We observe some features appearing at different heights during geomagnetic storms and sudden stratospheric warming events. We propose a method for comparative statistical analysis of the neutral wind registered at different sites and show its validity. Using this method, we make a quantitative comparison of winds measured over Eastern Siberia in the winter-spring period. The wind measured by the meteor radar and Fabry-Perot interferometer at 90 km has similar direction and absolute velocity. The wind measured by the Fabry—Perot interferometer at 100 km differs from that estimated by the meteor radar only in direction. The wind measured by the Fabry—Perot interferometer at 250 km has a velocity 2.5 times faster and a direction differing by 30–40° from the wind obtained by the meteor radar.
Interannual dynamics in intensity of mesoscale hydroxyl nightglow variations over Almaty
Authors: Попов А. , Popov A. , Гаврилов Николай , Gavrilov Nikolay , Андреев А. , Andreev A. , Погорельцев Александр , Pogoreltsev Aleksandr
Published: June 2018

The method of digital difference filters is applied to the data analysis of SATI observations of hydroxyl nightglow intensity and rotational temperature at altitudes 85–90 km over Almaty (43°03' N, 76°58' E), Kazakhstan, in 2010–2017. We examine seasonal and interannual variations in monthly average values and standard deviations of variations with periods 0.4–5.4 hrs, which may be associated with internal gravity waves in the mesopause region. The monthly average temperature near the mesopause has a maximum in winter and a minimum in June. The monthly average intensity has an additional maximum in June. Standard deviation of mesoscale rotational temperature variations and characteristics of internal gravity waves are maximum in spring and autumn. The spring maximum of mesoscale OH emission intensity variations is shifted to June. Interannual variations and multi-year trends of OH rotational temperature and emission intensity may differ in detail. This may be connected with seasonal and long-term variations in the complex system of the photochemical processes, which produce the OH nightglow.
The presence of a systematic error in SDO/HMI data
Authors: Руденко Георгий , Rudenko Georgiy , Дмитриенко Ирина , Dmitrienko Irina
Published: June 2018

In this paper, we came to the conclusion that there is a systematic error in SDO/HMI (Helioseismic and Magnetic Imager aboard the Solar Dynamics Observatory) vector magnetic data, which reveals itself in a deviation from the radial direction of the knot mag-netic fields manifesting themselves on magnetograms in the form of small grains in a strong magnetic field. This deviation demonstrates a dependence on the distance to the disk center, which cannot be a property of the magnetic field – it can only be artificially introduced into the data. We suggest a simple method for correcting vector magnetograms, which eliminates the detected systematic error.
Variations in ratio and correlation of solar magnetic fields in the Fe I 525.02 nm and Na I 589.59 nm lines according to Mount Wilson measurements during 2000–2012
Authors: Голубева Елена , Golubeva Elena
Published: June 2018

Variations in the solar magnetic-field ratio over 13 years are analyzed, relying on the comparison of simultaneous measurements in two spectral lines at the Mount Wilson Observatory. The ratio and correlation coefficient are calculated over the general working range of measured magnetic-field values and in various ranges of field magnitudes. We study variations in both the parameters. We have found the following tenden-cies: i) the parameters show changes with solar cycle in the general case; ii) their dependence on magnetic-field magnitude is a nonlinear function of time, and this is especially pronounced in the ratio behavior; iii) several separate ranges of the field magnitudes can be distin-guished based on the behavioral patterns of variations in the ratio. We discuss correspondences between these ranges and the known structural objects of the solar atmosphere. This leads to a conclusion that the dependence of the parameters on magnetic-field magnitude and time is connected with the variety of magnetic structural components and their cyclic rearrangements. The reported results may be useful for solving interpretation problems of solar magnetic-field meas-urements and for the cross-calibration of applicable instruments. They can also be used for tasks related to the creation of a uniform long temporal series of solar magnetic-field data from various sources.
If you want to grow your clinic's brand, you need to be more selfish
Authors: Ratcliffe Jason
Published: June 2018

Running a small business takes a huge amount of work, and it is easy to burn yourself out. To be on top of your game both personally and professionally, it is important to learn when to put yourself first. In this month's column, Jason Ratcliffe explores a controversial topic for clinic owners—when to be selfish. He will examine when you need to look after your own needs before helping others
Long-term results of scapulothoracic arthrodesis with multiple cable method for facioscapulohumeral dystrophy
Authors: Erşen A. , Atalar A. C. , Bayram S. , Demirel M. , Tunalı O. , Demirhan M.
Published: June 2018

Aims

The present study aimed to investigate the long-term functional results of scapulothoracic fusion using multifilament cables in patients with facioscapulohumeral dystrophy (FSHD) to identify if the early improvement from this intervention is maintained.

Patients and Methods

We retrospectively investigated the long-term outcomes of 13 patients with FSHD (18 shoulders) in whom scapulothoracic fusion using multifilament cables was performed between 2004 and 2007. These patients have previously been reported at a mean of 35.5 months (24 to 87). There were eight men and five women with a mean age of 26 years. Their mean length of follow-up of our current study was 128 months (94 to 185). To evaluate long-term functional results, the range of shoulder flexion and abduction, Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) scores were analyzed with a comparison of preoperatively, interim and at the final outcomes. The fusion was examined radiographically in all.

Results

The complication rate was 33% (six of 18 scapulothoracic fusions) in 13 patients, which comprised failure of fusion in four shoulders (four patients) all occurring within the first year postoperatively. In two shoulders (one patient) wound problems arose due to attribution from the cables which required shortening but the fusion developed satisfactorily. At the final examination, the mean QuickDASH score and range of movement significantly improved in all but one patient (p < 0.001, p < 0.001 and p < 0.001). In the comparison of 13 patients’ mid- and long-term results, the mean QuickDASH score decreased from 9.8 (sd 6.7; 3 to 26) in the third year to 9.1 (sd 5.6; 3 to 22) in the tenth year (p = 0.7); the mean range of shoulder flexion and abduction decreased from 129° (sd 22°; 90° to 160°) and 124° (sd 12; 100° to 150°) at the mid-term to 103° (sd 12°; 80° to 120°) and 101° (sd 8°; 80° to 120°) at the long-term, respectively (p = 0.78 and p = 0.65).

Conclusion

Scapulothoracic fusion using a multiple cabling method can confer a considerable improvement in clinical and functional outcomes for most patients with FSHD after a long follow-up period. The technique requires careful execution to avoid complications. Cite this article: Bone Joint J 2018;100-B:953–6.
Robotic-arm assisted total knee arthroplasty is associated with improved early functional recovery and reduced time to hospital discharge compared with conventional jig-based total knee arthroplasty
Authors: Kayani B. , Konan S. , Tahmassebi J. , Pietrzak J. R. T. , Haddad F. S.
Published: June 2018

Aims

The objective of this study was to compare early postoperative functional outcomes and time to hospital discharge between conventional jig-based total knee arthroplasty (TKA) and robotic-arm assisted TKA.

Patients and Methods

This prospective cohort study included 40 consecutive patients undergoing conventional jig-based TKA followed by 40 consecutive patients receiving robotic-arm assisted TKA. All surgical procedures were performed by a single surgeon using the medial parapatellar approach with identical implant designs and standardized postoperative inpatient rehabilitation. Inpatient functional outcomes and time to hospital discharge were collected in all study patients.

Results

There were no systematic differences in baseline characteristics between the conventional jig-based TKA and robotic-arm assisted TKA treatment groups with respect to age (p = 0.32), gender (p = 0.50), body mass index (p = 0.17), American Society of Anesthesiologists score (p = 0.88), and preoperative haemoglobin level (p = 0.82). Robotic-arm assisted TKA was associated with reduced postoperative pain (p < 0.001), decreased analgesia requirements (p < 0.001), decreased reduction in postoperative haemoglobin levels (p < 0.001), shorter time to straight leg raise (p < 0.001), decreased number of physiotherapy sessions (p < 0.001) and improved maximum knee flexion at discharge (p < 0.001) compared with conventional jig-based TKA. Median time to hospital discharge in robotic-arm assisted TKA was 77 hours (interquartile range (IQR) 74 to 81) compared with 105 hours (IQR 98 to 126) in conventional jig-based TKA (p < 0.001).

Conclusion

Robotic-arm assisted TKA was associated with decreased pain, improved early functional recovery and reduced time to hospital discharge compared with conventional jig-based TKA. Cite this article: Bone Joint J 2018;100-B:930–7.
Non-steroidal anti-inflammatory drugs for heterotopic ossification prophylaxis after total hip arthroplasty
Authors: Joice M. , Vasileiadis G. I. , Amanatullah D. F.
Published: June 2018

Aims

The aim of this study was to assess the efficacy of non-selective and selective non-steroidal anti-inflammatory drugs (NSAIDs) in preventing heterotopic ossification (HO) after total hip arthroplasty (THA).

Methods

A thorough and systematic literature search was conducted and 29 studies were found that met inclusion criteria. Data were extracted and statistical analysis was carried out generating forest plots.

Results

Non-selective NSAIDs showed a significant decrease in the odds for forming HO after THA (odds ratio (OR) -1.35, confidence interval (CI) -1.83 to -0.86) when compared with placebo. Selective NSAIDs also showed a significant decrease in the odds for forming HO after THA when compared with placebo (OR -1.58, CI -2.41 to -0.75). When comparing non-selective NSAIDs with selective NSAIDs, there was no significant change in the odds for forming HO after THA (OR 0.22, CI -0.36 to 0.79).

Conclusion

Our meta-analyses of all available data suggest that both non-selective and selective NSAIDs are effective HO prophylaxis and can be used routinely after THA for pain control as well as prevention of HO. Indomethacin may serve as the benchmark among non-selective NSAIDs and celecoxib among selective NSAIDs. There was no difference in the incidence of HO between non-selective and selective NSAIDs, allowing physicians to choose either based on the clinical scenario and patient-specific factors. Cite this article: Bone Joint J 2018;100-B:915–22.
Which factors influence proximal femoral asymmetry?
Authors: Laumonerie P. , Ollivier M. , LiArno S. , Faizan A. , Cavaignac E. , Argenson J-N.
Published: June 2018

Aims

In patients where the proximal femur shows gross deformity due to degenerative changes or fracture, the contralateral femur is often used to perform preoperative templating for hip arthroplasty. However, femurs may not be symmetrical: the aim of this study was to determine the degree of variation between hips in healthy individuals and to determine whether it is affected by demographic parameters.

Materials and Methods

CT-scan based modelling was used to examine the pelvis and bilateral femurs of 345 patients (211 males, 134 women; mean age 62 years (standard deviation (sd) 17), mean body mass index 27 kg/m2 (sd 5)) representing a range of ethnicities. The femoral neck-shaft angle (NSA), femoral offset (FO), femoral neck version (FNV), femoral length (FL), femoral canal flare index (fCFI), and femoral head radius (FHr) were then determined for each patient. All measurements were constructed using algorithm-calculated landmarks, resulting in reproducible and consistent constructs for each specimen. We then analyzed femoral symmetry based on absolute differences (AD) and percentage asymmetry (%AS) following a previously validated method.

Results

We found an asymmetry > 2% for NSA (mean AD 2.9°, mean %AS 2.3; p = 0.03), FO (AD 3.8 mm, %AS 9.1 ; p = 0.01), FNV (AD 5.1°, %AS 46.7 ; p = 0.001) and fCFI (AD 0.2 mm, %AS 5.4 ; p = 0.7). Significant relationships were found for AD regarding NSA and ethnicity (p = 0.037), FL and height (R2 = 0.22), and fCFI and gender (R2 = 0.34).

Conclusion

Our data confirm the presence of asymmetry of proximal femurs, which is mostly independent of demographic parameters. In cases where contralateral templating is used, such asymmetry may lead to inaccurate anatomical restoration of the hip if the templated sizes are routinely implanted. However, the clinical impact cannot be determined from our investigation. Cite this article: Bone Joint J 2018;100-B:839–44.
Ten-year survivorship of primary total hip arthroplasty in patients 30 years of age or younger
Authors: Makarewich C. A. , Anderson M. B. , Gililland J. M. , Pelt C. E. , Peters C. L.
Published: June 2018

Aims

For this retrospective cohort study, patients aged ≤ 30 years (very young) who underwent total hip arthroplasty (THA) were compared with patients aged ≥ 60 years (elderly) to evaluate the rate of revision arthroplasty, implant survival, the indications for revision, the complications, and the patient-reported outcomes.

Patients and Methods

We retrospectively reviewed all patients who underwent primary THA between January 2000 and May 2015 from our institutional database. A total of 145 very young and 1359 elderly patients were reviewed. The mean follow-up was 5.3 years (1 to 18). Logistic generalized estimating equations were used to compare characteristics and the revision rate. Survival was evaluated using Kaplan–Meier curves and hazard rates were created using Cox regression.

Results

The overall revision rate was 11% (16/145) in the very young and 3.83% (52/1359) in the elderly groups (odds ratio (OR) 2.58, 95% confidence interval (CI) 1.43 to 4.63). After adjusting for the American Society of Anesthesiologists (ASA) score, gender, and a history of previous surgery in a time-to-event model, the risk of revision remained greater in the very young (adjusted hazard ratio (HR) 2.48, 95% CI 1.34 to 4.58). Survival at ten years was 82% (95% CI, 71 to 89) in the very young and 96% (95% CI, 94 to 97) in the elderly group (p < 0.001). The very young had a higher rate of revision for complications related to metal-on-metal (MoM) bearing surfaces (p < 0.001). At last follow-up, the very young group had higher levels of physical function (p = 0.002), lower levels of mental health (p = 0.001), and similar levels of pain (p = 0.670) compared with their elderly counterparts.

Conclusion

The overall revision rate was greater in very young THA patients. This was largely explained by the use of MoM bearings. Young patients with non-MoM bearings had high survivorship with similar complication profiles to patients aged ≥ 60 years. Cite this article: Bone Joint J 2018;100-B:867–74.
Riesgos y potenciales de preservación patrimonial en América Latina y el Caribe
Authors: Costa Everaldo Batista da
Published: June 2018

La racionalidad instrumental del desarrollo que se asume en América Latina y el Caribe genera serios daños para el patrimonio y la vida. Por lo tanto, se analizan los principales riesgos y los potenciales de preservación en sitios Patrimonio de la Humanidad, para generar nuevos enfoques sobre patrimonio en el continente. Metodológicamente, la investigación presenta dos momentos analíticos: i) define los problemas originarios de riesgos en la región (abordaje y conexiones); ii) identifica los riesgos (R) y los potenciales de preservación patrimonial (Pp) en el continente (cuadro de síntesis para sitios en Perú, México, Cuba, Panamá y Brasil). El análisis empírico (siete bienes de cinco países) genera variables que pueden estimular políticas de gestión de riesgos para los sitios y la vida, así como reforzar los conceptos patrimonio-territorial y territorio de excepción en las prácticas alternativas de preservación en América Latina y el Caribe.
Produksi Biomassa Mikroalga (Tetraselmis chuii) Dengan Sistem Pemanenan Berbeda
Authors: Djunaedi Ali
Published: June 2018

Permasalahan yang sering terjadi adalah masih rendahnya berat biomassa yang dihasilkan pada pemanenan mikroalga. Penelitian bertujuan untuk mengetahui tingkat berat kering biomassa T. chuii pada perbedaan sistem pemanenan. Penelitian ini dirancang menggunakan Rancangan Acak Lengkap (RAL) dengan perbedaan sistem pemanenan filtrasi, centrifuge dan flokulasi. Hasil penelitian menunjukkan terdapat perbedaan berat kering biomassa T. chuii. Pada sistem pemanenan filtrasi diperoleh berat kering biomassa sebesar 3,899 ± 0,073 gr, pemanenan centrifuge sebesar 4,242 ± 0,129 gr dan pemanenan flokulasi sebesar 5,65 ± 0,026 gr. Perbedaan sistem pemanenan memberikan pengaruh sangat nyata (p<0,01) terhadap berat kering biomassa.Kata Kunci : Berat kering biomassa, filtrasi, centrifuge dan flokulasi, Tetraselmis chuii.Tetraselmis chuii is known as the higher quality natural food. The cultivation of T. chuii produce the high density, but the harvesting systems reduce it. The aim of the research was to find the appropriate harvesting system to the T. chuii biomass production. The T. chuii cultivations were done using the 30 liters plastic tank, with three replications. There were three treatments, which were applied, such as: filtration, centrifugation and flocculation, using the Completely Randomized Design. The results of this research showed, that the applied of varying harvesting systems to dry weight of T. chuii biomass was significant difference (p<0,01) respectively. The dry weight of microalgae biomass at applied of filtration system was obtained value of 3,89 ± 0,073 g, in centrifugation system of 4,23 ± 0,126 g, and than in the flocculation system of 5,65 ± 0,026 g.Keywords : Biomass Production; Filtration; Flocculation Centrifugation; Tetraselmis chuii.
Potensi Rumput Laut Eucheuma sp. Terhadap Kepadatan Fitoplankton Chlorella sp.
Authors: Azizah Ria , Sulistianingtiyas Indrihastuti , Pringgenies Delianis , Rudiyanti Siti
Published: June 2018

Chlorella sp. merupakan sumber makanan bagi ikan dan udang. Untuk menumbuhkan, Chlorella sp. maka diperlukan media kultur dengan nutrien yang baik. Eucheuma sp. merupakan rumput laut yang mengandung mineral - mineral yang bermanfaat bagi pertumbuhan Chlorella sp. Pemberian ekstrak Eucheuma sp. diharapkan dapat mendukung pertumbuhan Chlorella sp. Tujuan dilakukan penelitian untuk mengetahui pengaruh ekstrak Eucheuma sp. terhadap kepadatan Chlorella sp. dan konsentrasi terbaik dari ekstrak Eucheuma sp. yang menghasilkan kepadatan Chlorella sp. yang tertinggi. Penelitian ini dilaksanakan pada bulan Januari - Maret 2005 di Laboratorium Bioteknologi dan Eksplorasi Laut, Teluk Awur, UNDIP, Jepara dan Laboratorium Jurusan Perikanan, UNDIP, Semarang. Materi yang digunakan yaitu ekstrak Eucheuma sp., Chlorella sp. dan media kultur. Metode yang digunakan adalah eksperimental laboratories. Konsentrasi ekstrak Eucheuma sp. yang digunakan adalah : A (10 mg/L); B (100 mg/L); C (200 mg/L); D (300 mg/L); E (400 mg/L); F (500 mg/L); G ( tanpa pemberian ekstrak Eucheuma sp.).Hasil penelitian menunjukkan perlakuan D (300 mg/L) menghasilkan kepadatan Chlorella sp. tertinggi pada puncak populasi, yaitu 6,293 log sel/mL dan pada akhir populasi, yaitu 6,012 log sel/mL dengan konstanta pertumbuhan spesifik sebesar 0,161.Kata kunci: Kepadatan, Chlorella, EucheumaChlorella sp. is the source of food to prawn and fish. In order to grow Chlorella sp. so need a culture media with a good nutrient. Eucheuma sp. is a seaweed it cantains benefit minerals for the growth of Chlorella sp. The giving of Eucheuma sp. it is to be hoped to support the the growth of Chlorella sp. This research is aimed to know the effect of Eucheuma sp. extract to density of Chlorella sp. and the best concentration of Eucheuma sp. extract produce the highest density of Chlorella sp. This research was conducted in January – March 2005 at the Laboratory of Biotechnology and Marine Exploration, Teluk Awur, UNDIP, Jepara and Laboratory of Fisheries Department UNDIP, Semarang. Materials used in this research consisted of Eucheuma sp. extract, Chlorella sp. and culture media. This research method used experimental laboratories. The concentration that used in this research : A (10 mg/L); B (100 mg/L); C (200 mg/L); D (300 mg/L); E (400 mg/L); F (500 mg/L); G ( without giving extract of Eucheuma sp.). The result of this research showed that the D treatment produce the highest Chlorella sp. density at peak of population, that is 6,293 log sel/mL and the end of population that is 6,012 log sel/mL with specific growth rate 0,161.Keyword : Density, Chlorella., Eucheuma
Pertumbuhan dan Prosentase Molting pada Kepiting Bakau (Scylla serrata Forsskäl,1775) dengan Pemberian Stimulasi Molting Berbeda
Authors: Djunaedi Ali
Published: June 2018

Produksi kepiting bakau (S. serratta Forsskäl, 1775) sangat dipengaruhi oleh pertumbuhan, tingkat kelulushidupan dan prosentase moulting. Studi tentang pengaruh metode perangsangan moulting kepiting bakau merupakan salah satu usaha untuk meningkatkan produksi. Penelitian ini bertujuan untuk mengetahui pengaruh berbagai metode perangsangan moulting terhadap prosentase moulting, kelulushidupan dan pertumbuhan. Penelitian menggunakan metode eksperimental  dengan Rancangan Acak Lengkap (RAL). Penelitian menggunakan biota uji 120 ekor kepiting bakau (S. serrata Forsskäl, 1775) betina. Perlakuan metode perangsangan moulting yaitu, ablasi, autotomi dan penyuntikan hormon ovaprim dan kontrol, masing-masing diulang 3 kali. Pengamatan dilakukan pada, persentase moulting, kelulushidupan, pertumbuhan dan kualitas air. Hasil penelitian menunjukkan bahwa terdapat perbedaaan sangat nyata (p>0,01) pada berbagai perlakuan metode perangsangan moulting terhadap persentase moulting, kelulushidupan dan pertumbuhan. Perlakuan metode ablasi menunjukkan hasil  paling tinggi, dengan persentase moulting 80 ± 10%, kelulushidupan 83,34 ± 5,78% dan laju pertumbuhan spesifik harian 5,36 ± 0,34%/hari. Sedangkan hasil terendah dicapai oleh perlakuan metode autotomi  dengan persentase moulting 13,33 ± 5,78%, kelulushidupan 16,67 ± 5,7% dan laju pertumbuhan spesifik harian 1,81 ± 0,22%/hari. Metode ablasi mata baik untuk diterapkan dalam merangsang moulting di dalam pemeliharaan kepiting bakau guna menunjang peningkatan produksi. Kata Kunci : Kepiting bakau, Scylla serratta, Kelulushidupan, Moulting, Pertumbuhan
The Legal, Political, Philosophical and Religious Dimension of Socrates’ Trial and Execution
Authors: Beys Kostas E.
Published: June 2018

The article deals with the legal, political, philosophical and religious dimensions of Socrates’ trial and execution. It considers the issue in five separate aspects: 1) the validity of charging Socrates with impiety and corrupting the youth of the Athens; 2) the legal basis of the philosopher’s indictment; 3) the then manner of conducting a legal trial in the Athens; 4) the extent to which Socrates’ conviction can ultimately be characterized as unjust and — finally — 5) the cultural ramifications of the philosopher’s trial and execution.
Controversy over the Power Between the Papacy and the Empire in the light of Marsilius’ of Padua Defensor pacis
Authors: Białas Anna
Published: June 2018

The most famous medieval controversy over the power and the temporal dominion took place between the papacy and the empire. One of the greatest advocates of the imperial domination was Marsilius of Padua, the author of an original work that demonstrated the advantage of acknowledging the emperor’s superiority over the Pope’s. The Defensor pacis, written between 1319 and 1324, was devoted to the dispute on such sovereignty issues as proving that the Pope should be subordinate to the Emperor, and not vice versa. The Defensor pacis takes issue with numerous arguments and views uttered by the papal camp and uses the appropriate quotations from the Bible and Aristotle to show their weakness and inconsistency. The work comprises three parts. The first part is a description of the ideal system, i.e., an elective monarchy, with the specified role of a ruler and a clear indication of the sovereignty of the people. The second and third parts present a challenge to the arguments of the papal camp (including the famous argument of the “power keys”) and analyze the general situation of the Church, suggesting the necessary reforms. Thus, the whole work becomes a compendium of knowledge on appropriate governance.
Divine Command and Socratic Piety in the Euthyphro
Authors: Koehn Glen
Published: June 2018

While Socrates was in his own way a deeply religious man, the Euthyphro is often thought to provide a refutation of the divine command theory of morality: the theory that what is morally good is good because it is divinely approved. Socrates seems to suggest that what is holy or pious (ὅσιος) is pleasing to the gods because it is holy, and not holy because it pleases them. Thus the dialogue is sometimes presented as showing that what is morally good and bad must be independent of the divine will. I argue that matters are not so simple, since there are several ways in which the gods could help determine which acts are good, for instance, by disposing certain human affairs which are relevant to moral decisions. Moreover, Socrates suggests that he has obligations to the gods themselves, and these obligations would have to depend in part on what pleases them. It follows that the dilemma which Socrates poses to Euthyphro (pious because loved by the gods, or loved by the gods because pious) does not offer two mutually exclusive alternatives. There are various ways for the preferences of such gods to help determine which acts are adequate for moral praise or blame. It could therefore hardly be the case that religious doctrines, if true, are irrelevant to the content of morality. Knowledge of the gods’ preferences, if such knowledge were available, would be of importance to moral theory. Socrates himself does not deny this, nor should we.
Why Not Escape? On the Hosiotes in Plato’s Crito
Authors: Komorowska Joanna
Published: June 2018

While the article discusses the factors that motivated Socrates’ decisionin the Crito, it emphasizes the possible cultural import of the choiceundertaken in the aftermath of the political upheavals in the late fifthcentury. It is also argued here that as Plato’s dialogue were written inthe period that followed the renewal of the Athenian politeia, it shouldbe perceived as having its roots both in the historical reality of its narrativefocus (i.e. Socrates’ trial) and in the then reality of Plato’s Athens(i.e., its political stability dependent on the ephebic oath).
Some Remarks on the Nineteenth Century Studies of the Euthyphro in Poland
Authors: Mróz Tomasz
Published: June 2018

The present paper examined how Polish philosophers, historians and classicists understood and interpreted Plato’s Euthyphro in the 19th century. The article provides evidence for a twofold interest that Polish readers had for the dialogue in this period. Firstly, Catholic think­ers focused on the ethical issues of the dialogue and supported the reviv­al of the Scholasticism, confirming, at the same time, the vitality of Plato’s thought. Secondly, the text of Plato’s opusculum was a conveni­ent didactic material for various teachers of the Greek language: while the Euthyphro gave them the opportunity to raise ethical and logical issues, they also taught philosophy on the basis of this dialogue.