bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence and antimicrobial resistance of Salmonella spp. isolated from chicken meat in upper northeastern Thailand
Authors:   Research Group for Animal Health Technology, Department of Anatomy, Khon Kaen University, Khon Kaen, Thailand, Vidayanti Istiana Nur , Sukon Peerapol ,   Research Group for Animal Health Technology, Department of Anatomy, Khon Kaen University, Khon Kaen, Thailand, Khaengair Seri ,   Research Group for Animal Health Technology, Department of Veterinary Public Health, Khon Kaen University, Khon Kaen, Thailand, Pulsrikarn Chaiwat ,   Department of Medical Sciences, Ministry of Public Health, Bangkok, Thailand, Angkittitrakul Sunpetch ,   Research Group for Animal Health Technology, Department of Veterinary Public Health, Khon Kaen University, Khon Kaen, Thailand
Published: November 2021

Foodborne disease associated with Salmonella spp. occurs in some parts of the world, including Thailand. The present study aimed to determine prevalence, antimicrobial resistance, and serotypes of Salmonella spp. isolated from chicken meat in upper northeastern Thailand. A total of 326 swab samples of fresh chicken meat were collected from wet markets in Khon Kaen, U-don Thani, Nong Khai, Loei, Kalasin, Maha Sarakham, and Bueng Kan Provinces, northeastern Thailand, between August and November 2019. All samples were analyzed for Salmonella spp. using the ISO 6579:2002/AMD 1:2007 method. The isolates were tested for antimicrobial susceptibility using the Kirby-Bauer method, and the serotypes of isolates positive were identified. The overall prevalence of Salmonella spp. isolated from chicken meat was 36.2% (118/326), and prevalence in the provinces was as follows: U-don Thani, 70.9%; Bueng Kan, 66.67%; Khon Kaen, 45.9%; Kalasin, 31.25%; Nong Khai, 29.8%; Maha Sarakham, 26.42% and Loei, 12.5%. Resistance was highest for nalidixic acid at 31%, followed by ampicillin (24%), tetracycline (19%), sulfamethoxazole trimethoprim (8%), norfloxacin (5%), ciprofloxacin (4%), amoxicillin (4%), and chloramphenicol (1%). However, all isolates were susceptible to ceftazidime. Twenty-seven serotypes were detected, with the Corvallis, Singapore, Kentucky and Agona serotypes being the most common. Salmonella spp. were detected in a large percentage of the swab samples of chicken meat in every city, indicating a high level of contamination of chicken meat. Given the high resistance of Salmonella strains to some antibiotics, it may be beneficial to find other drugs for salmonellosis treatment and to use antibiotics more wisely.
OXA-48-positive carbapenem-resistant Enterobacteriaceae in a farrow-to-finish pig farm: First report in Thailand
Authors:   Interdisciplinary Veterinary Science, Graduate School, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, Thailand, Phongsarmsuan Phaphatsanant , Angkititrakul Sunpetch ,   Division of Veterinary Public Health, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, Thailand, Jittimanee Suphattra ,   Division of Pathobiology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, Thailand, Phuektes Patchara ,   Division of Pathobiology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
Published: November 2021

Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as an urgent threat to public health. This study aimed to determine the occurrence of CRE and the carbapenemase genes in a farrow-to-finish pig farm, and to investigate carriage proportion and maintenance of CRE during the pig production cycle. We conducted a cross-sectional study by collecting 200 rectal swabs from healthy pigs of 5 groups: gilts, sows, piglets, weaners, and fatteners. In the longitudinal study, 20 healthy pigs were followed from 2 to 26 weeks old, and rectal swabs were collected from each pig for 5 times. Samples were screened for CRE using MacConkey agar supplemented with meropenem at 0.5 µg/mL. Identification and antimicrobial susceptibility pattern of the recovered isolates were determined using an automated system. PCR was used to detect carbapenemase genes. The occurrence of Enterobacteriaceae isolates with the carbapenem resistant phenotype and/or harboring the blaOXA-48 gene was 3% (6/200) in the cross-sectional study. Groups of sows and piglets had the same occurrence rate at 5% (2/40), while weaner and fattener groups had 2.5% (1/40). In the longitudinal study, CRE were not detected in pigs at an early age; however, two isolates were detected at the age of finishing. This study is the first report of Enterobacteriaceae with a carbapenem resistant phenotype and/or carrying blaOXA-48 gene in pigs in Thailand. Finding CRE in pigs at all age categories including finisher in the study farm underscores the need for active monitoring and surveillance studies to determine the occurrence of CRE in pig farms in Thailand.
Current perspectives on ruminant sperm freezability: Harnessing molecular changes related to semen quality through omics technologies
Authors:   Department of Veterinary Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand, Salinas Marvin Bryan ,   Department of Morphophysiology and Pharmacology, College of Veterinary Science and Medicine, Central Luzon State University, Science City of Muñoz 3120, Nueva Ecija, Philippines, Chuammitri Phongsakorn ,   Department of Veterinary Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand, Sringarm Korawan ,   Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50100, Thailand, Boonyayatra Sukolrat ,   Department of Food Animal Clinic, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand, Sathanawongs Anucha ,   Department of Veterinary Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand
Published: November 2021

The recent advances in sperm cryopreservation transcend cryobanking and other assisted reproductive technologies. Since its discovery, cryopreservation has contributed positive impacts on animal breeding as well as in genetic exchange, improvement, and conservation efforts. However, cryoinjury and variabilities in cryopreservation outcomes remain as key challenges to sperm cryobiology. The present work explored the molecular bases for such freezability differences and freezing-thawing injuries in the ruminant sperm. Relevant biomarkers identified in the seminal plasma and the spermatozoa were highlighted, including lipids, proteins, metabolites, transcripts, and genes. Specific molecular mechanisms concerning sperm structures and functions were also examined relative to their association to cryotolerance, and spermiogram or seminogram modifications following cryopreservation procedures. Current conflicts and gaps in the knowledge base on ruminant spermatozoa were also emphasized. Further investigation of these areas using the available breakthrough molecular tools such as omics technologies is therefore proposed to improve, optimize, or even predict the overall quality of frozen-thawed ruminant semen towards reproductive efficiency.
Long-term patient-reported outcomes for open surgery of the triangular fibrocartilage complex
Authors: Feitz Reinier , Khoshnaw Sara , van der Oest Mark J. W. , Souer J. Sebastiaan , Slijper Harm P. , Hovius Steven E. R. , Selles Ruud W. ,   On behalf of the Hand-Wrist Study Group
Published: November 2021

Aims

Studies on long-term patient-reported outcomes after open surgery for triangular fibrocartilage complex (TFCC) are scarce. Surgeons and patients would benefit from self-reported outcome data on pain, function, complications, and satisfaction after this surgery to enhance shared decision-making. The aim of this study is to determine the long-term outcome of adults who had open surgery for the TFCC.

Methods

A prospective cohort study that included patients with open surgery for the TFCC between December 2011 and September 2015. In September 2020, we sent these patients an additional follow-up questionnaire, including the Patient-Rated Wrist Evaluation (PRWE), to score satisfaction, complications, pain, and function.

Results

A total of 113 patients were included in the analysis. At ≥ 60 months after an open TFCC reinsertion, we found a mean PRWE total score of 19 (SD 21), a mean PRWE pain score of 11 (SD 11), and a PRWE function score of 9 (SD 10). The percentage of patients obtaining minimum clinically important difference rose from 77% at 12 months to 83% at more than 60 months (p < 0.001). Patients reported fewer complications than surgeons, and overall complication rate was low.

Conclusion

Outcomes of patient-reported pain, function scores, and satisfaction are improved five years after open surgery for the TFCC. Cite this article: Bone Jt Open 2021;2(11):981–987.
Compressive imaging for thwarting adversarial attacks on 3D point cloud classifiers
Authors: Kravets Vladislav , Javidi Bahram , Stern Adrian
Published: November 2021

Three dimensional (3D) point cloud classifiers are used extensively in safety crucial applications such as autonomous cars, face recognition, military applications, and many more. Despite the critical importance of their reliability, 3D classifiers are prone to adversarial attacks that can be crafted in the real world. While it is possible to use known methods to prevent adversarial attacks, they can be easily counter-attacked, leading to an arms race between the attacker and the defender. Here, we propose to use 3D compressive sensing to recover an original label of the 3D object. Since compressive sensing inherently encodes the 3D signal, it also prevents the arms race between the attacker and the defender. The 3D compressive sensing we consider is a single pixel camera (SPC) system that can be implemented in Light Detection and Ranging (LiDAR) systems.
Characteristics of spectral peaking in optical fibers
Authors: Nishizawa Norihiko , Yamanaka Masahito
Published: November 2021

We investigated multiple spectral peak generation during a coherent supercontinuum generation process with normal-dispersion highly nonlinear fibers both numerically and experimentally. Wideband multiple spectral peak generation was achieved in the 1.6–1.7 μm range using an ultrashort-pulse fiber laser, a CH4 gas cell, and highly nonlinear fiber. The maximum signal-to-background ratio was ∼8.4. Thanks to the normal-dispersion fibers, the induced phase shifts in the absorption spectra were clearly observed on the spectra during the spectral peak generation. The intensity and phase noise properties of the generated spectral peaks were examined, and low noise properties were confirmed. The spectral peaking phenomenon was investigated experimentally in a fiber amplifier. Periodical spectral peaking was successfully observed for a soliton pulse with Kelly sidebands, and the optical pulse experienced absorption in HCN gas. It is expected that spectral peaking occurs for pulses that experience absorption in many different kinds of gas species or those with spectral peaks. This light source and phenomenon will be useful for developing novel optical frequency comb techniques and optical wavelength standards.
Information advantage from polarization-multiplexed readout of nanophotonic scattering overlay sensors
Authors: Buijs Robin D. , Wolterink Tom A. W. , Gerini Giampiero , Femius Koenderink A. , Verhagen Ewold
Published: November 2021

Nanophotonic structures are powerful tools for sensing, with the goal of retrieving parameters accurately at maximum speed and minimum photon budget. As information on those parameters can be distributed over multiple output scattering channels that propagate to the far field, considering well-chosen combinations of far-field optical degrees of freedom could benefit measurement precision. We explore how multiplexing readout across different polarization channels enhances parameter retrieval in nanophotonic overlay sensors. We measure the relative position between layers with nanoscale scattering structures, known as overlay in semiconductor metrology, and show that multiplexing either incident or analyzed polarization leads to improved parameter retrieval in the systems studied. At fixed photon budget, we extract additional information equivalent to more than 7 dB in signal level. These results demonstrate that significant advantages in measurement performance of nano-optical sensors can be gained by exploiting the vectorial nature of optical fields.
Analysing stereotypical food consumption behaviours: ‘This way up?’ Is there really a ‘right’ way to eat a biscuit?
Authors: Spence Charles
Published: November 2021

Many of the mundane foods that we eat on an everyday basis are consumed in a manner that may be considered stereotypical, conventional, habitual or, on occasion, even a playful ritual. There are a number of reasons for such behaviours, and the potential benefits for the consumer are discussed in the case of vertically asymmetrical foods where the upper and lower surfaces differ. Maximizing the eye appeal of the food product, maximizing the multisensory flavour experience and the ubiquitous benefits of ritual to the enjoyment of consumption experiences are all put forward as possible explanations for such behaviours in this opinion piece. Ultimately, however, the paucity of empirical evidence concerning the influence of the manner of eating such ubiquitous foods (right way-up or upside-down) on the multisensory tasting experience is highlighted. This is a seemingly important lacuna in the food science literature, given the multiple competing explanations concerning how such experiences might be affected, if at all, that suggest themselves. Looking to the future, it would clearly be of great interest, given the growing global obesity crisis, to understand whether it might be possible to increase sensory enjoyment and/or satiety by the better/optimized design of foods and/or food consumption behaviours.
Susceptibilidad de afección por enjambres de medusas (Pelagia noctiluca) en las playas del litoral occidental de la provincia de Málaga
Authors: De la Fuente Roselló Ana , Sortino Barrionuevo Juan Francisco , Reyes Corredera Sergio Jesús , Perles Roselló María Jesús
Published: November 2021

En el artículo se analiza y cartografía la susceptibilidad de afección por enjambres de medusas (Pelagia noctiluca) en las playas del litoral occidental de la provincia de Málaga. Los indicadores de peligrosidad de aparición de enjambres se elaboran a partir de un inventario de datos empíricos de avistamientos de medusas, registrados a través de la aplicación InfoMedusa (datos diarios para los meses estivales del periodo 2015-2020). Se proponen distintos indicadores de peligrosidad (frecuencia y severidad), y se calculan parámetros específicos que corrijan el problema del número desigual de observaciones en las playas. Los resultados cartográficos muestran que el patrón de distribución espacial no es aleatorio. Se observa una mayor frecuencia de episodios en las playas más occidentales del tramo estudiado, y el análisis preliminar de los factores condicionantes en cada playa permiten deducir una asociación de las playas con más propensión a recibir enjambres con la amplitud del ángulo de apertura de la misma, así como con la orientación al suroeste del tramo de costa en el que se sitúan las playas. Estas condiciones facilitan la entrada de las corrientes de levante procedentes del mar de Alborán, origen predominante de los enjambres.
Niebla en agosto (2016) y la sombra del pasado (2018). Aktion T4: el plan de eutanasia nazi para la eliminación de las personas con discapacidad
Authors: De Prada Pérez Francisco Javier
Published: November 2021

El ascenso al poder del nacionalsocialismo en Alemania y sus consecuencias ha sido una fuente inagotable para la inspiración de producciones cinematográficas. Sin embargo, el programa Aktion T4 más conocido por plan de eutanasia nazi, no había sido tema principal de una película hasta fechas recientes. Niebla en agosto (2016) y La Sombra del pasado (2018) son dos cintas que abordan los métodos empleados para el control y eliminación de las personas con discapacidad o, mejor dicho, de aquellas personas que no cumplían los cánones de la raza aria y además eran una carga económica para el estado alemán. Las leyes de esterilización, primero, el programa de eliminación de bebés nacidos con alguna clase de discapacidad y, por último, el programa Aktion T4 que seleccionaba y ordenaba el asesinato de las personas ingresadas en instituciones son las tres fases de un calculado plan de exterminio. Psiquiatras, personal de enfermería y otros médicos y sanitarios fueron los diseñadores, colaboradores y ejecutores de ese crimen contra la humanidad que fue, sin duda, un ensayo para el posterior genocidio judío. Todavía hoy se reclama en Alemania verdad, justicia y reparación para las casi 300.000 personas víctimas de esos crímenes olvidados.
Nociceptive pain and anxiety in equines: Physiological and behavioral alterations
Authors: Hernández-Avalos I. , Mota-Rojas D. , Mendoza-Flores J. E. , Casas-Alvarado A. , Flores-Padilla K. , Miranda-Cortes A. E. , Torres-Bernal F. , Gómez-Prado J. , Mora-Medina P.
Published: November 2021

Pain and anxiety are two of the most important concerns in clinical veterinary medicine because they arise as consequences of multiple factors that can severely affect animal welfare. The aim of the present review was to provide a description and interpretation of the physiological and behavioral alterations associated with pain and anxiety in equines. To this end, we conducted an extensive review of diverse sources on the topic. The article begins by describing the neurophysiological pathway of pain, followed by a discussion of the importance of the limbic system in responses to pain and anxiety, since prolonged exposure to situations that cause stress and pain generates such physiological changes as tachycardia, tachypnea, hypertension, hyperthermia, and heart rate variability (HRV), often accompanied by altered emotional states, deficient rest, and even aggressiveness. In the long term, animals may show deficiencies in their ability to deal with changes in the environment due to alterations in the functioning of their immune, nervous, and endocrinologic systems. In conclusion, pain and anxiety directly impact the homeostasis of organisms, so it is necessary to conduct objective evaluations of both sensations using behavioral scales, like the horse grimace scale, complemented by assessments of blood biomarkers to analyze their correlation with physiological parameters: Heart rate, respiratory rate, HRV, the parasympathetic tone activity index, lactate and glucose levels, and temperature. Additional tools – infrared thermography, for example – can also be used in these efforts to improve the quality of life and welfare of horses.
Mucormycosis: A challenge with COVID-19
Authors: Islam Mohammod Kamrul
Published: November 2021

Mucormycosis is an aggressive opportunistic fungal infection caused by fungi of the Phycomycetes class including Rhizopus species and Mucor species. The pathogen can be present in the environment, on the skin, and in the orifices of the body. There are several types including Rhinocerebral, Pulmonary, Gastrointestinal, Cutaneous, and Disseminated Mucormycosis.1 The spores infect the paranasal sinuses and nasopharynx, extending to the orbit and brain cavity in persons who have reduced cellular and humoral defenses. During the ongoing COVID-19 pandemic, a surge in the cases of rhino-orbital mucormycosis has become a life-threatening combination. Early diagnosis and intervention in the only way to save the vision and life of the affected patient.
Tumor de Frantz: Relato de caso
Authors: Hugo Melo Carvalho Victor , Danilo Leite da Silva Rocha Kaio , Ivo Martins Cidade Pedro , Sávio Soares Macedo Allan , Fernandes Peixoto Furtado Maria Isabel , Araújo de Alencar Guiomar , Felippe de Araújo Rolim Francisco
Published: November 2021

Resumo: Neoplasias pseudopapilares sólidas (NPS) do pâncreas são neoplasias raras, responsáveis ​​por 1–2% de todos os tumores pancreáticos e têm uma predominância feminina em geral e são denominadas tumores de Frantz. O tratamento de escolha é a ressecção da lesão, uma vez que é frequentemente curativa. As características radiológicas são importantes para a hipótese diagnóstica, uma vez que o planejamento pré-operatório é fundamental para a obtenção da cura. O presente estudo tem como objetivo realizar um relato de caso com descrição da história clínica, do tratamento de um caso atípico de tumor de Frantz com apresentação clínico-radiológica rara, diagnosticado no Hospital Regional do Cariri. Para elaboração deste, foi realizada análise documental dos dados do prontuário do paciente.
Palavras-chave: Tumor de Frantz; neoplasia pseudopapilares; neoplasia pancreática.
Influence of the filling gas mixture on the interruption capability of medium voltage load break switches
Authors: Krampert Thomas , Bendig Marvin , Moser Albert , Schaak Martin
Published: November 2021

In today’s medium voltage switchgear SF6 is commonly used as insulating and arc quenching medium. Because of its high potential impact on the environment a substitution with an environmentally friendly alternative is pursued. In this paper the inﬂuence of the mixing ratio of carbon dioxide nitrogen mixtures as ﬁlling gas on the interruption capability in medium voltage load break switches is investigated. The interruption capability is regarded by means of the thermal interruption performance as well as the dielectric recovery of a model load break switch. The model load break switch allows an axial arc blowing with variable pressure and uses an exchangeable nozzle system.
Kajian Potensi dan Pemanfaatan Energi Panas Bumi di Wilayah Kerja Panas Bumi Patuha Ciwidey
Authors: Khasmadin Mochammad Fa'iq , Harmoko Udi
Published: November 2021

Potensi energi panas bumi yang dimiliki oleh Indonesia sangat besar dan pemanfaatannya belum optimal. Data dari Badan Geologi Kementrian ESDM menunjukkan bahwa potensi energi panas bumi di Indonesia mencapai 29,5 GW atau 40% dari potensi panas bumi di dunia. Pemanfaatan energi panas bumi di Indonesia untuk dikonversikan menjadi energi listrik sebesar 1.189MW (tahun 2014). Keunggulan pemanfaatan energi panas bumi adalah energi bersih dan ramah lingkungan. Energi panas bumi mampu menggantikan pembangkit berbahan bakar batu bara ataupun gas. Upaya dalam pemanfaatan energi panas bumi adalah dengan melakukan pembangunan PLTP di area WKP yang memiliki potensi energi panas bumi yang besar salah satunya adalah WKP Patuha Ciwidey yang masih masuk dalam WKP Pangalengan. Saat ini Kapasitas pembangkit yang dibangkitkan adalah mencapai 1x60MW. Kajian dalam penelitian ini bertujuan untuk mengetahui potensi dan pemanfaatan energi panas bumi di WKP Patuha Ciwidey. Teknologi yang digunakan pada PLTP Patuha Unit 1 adalah siklus uap kering (Direct Dry Steam Cycle) Fluida uap dialirkan secara langsung ke Turbin. Sistem konversi ini merupakan sistem konversi yang paling sederhana. Dalam kajian ini ditemukan bahwa secara lateral terdapat tiga reservoir di area Patuha yang saling terhubung diantara Kawah Putih Cibuni, dan Ciwidey yang dipisahkan oleh Sesar Normal Cimanggu sehingg memisahkan antara area reservoir Kawah Cibuni dan reservoir Kawah Putih, sedangkan sesar normal Cileulur memisahkan area reservoir Kawah Putih dan area reservoir Kawah Ciwidey. Sedangkan Kebutuhan uap yang digunakan dalam pembangkitan PLTP unit 1 Patuha yakni dengan inlet pressure 11 bar abs, tekanan kondensor 0.1 bar abs, dari hasil perhitungan diperkirakan unit 1 Patuha membutuhkan uap sekitar 370.8 ton/jam atau 103 kg/s dengan konsumsi uap rara-rata sebesar 6.75 ton/jam.MW. Dalam upaya menjaga dan mengembangkan pemanfaatan energi diperlukan perencanaan desain proyek seumur hidup long life sustainability, dengan mempertimbangkan kondisi lingkungan, prediksi sumur, perencanaan steamfield, dan simulasi reservoir.
Regulation of cell signaling pathways by Wogonin in different cancers: Mechanistic review
Authors: Butt Ghazala , Ozbey Ulku , Malik Durr-e-shahwar , Attar Rukset , Youssef Lara , Farooqi Ammad Ahmad
Published: November 2021

Natural products have historically been invaluable as a premium source of therapeutic agents. Recent advancements in genomics and structural biology have portrayed a high-resolution landscape of the diversity of proteins targeted by pharmacologically active products from natural sources. Natural product research has generated valuable wealth of information and cutting-edge research-works have leveraged our conceptual knowledge altogether to a new level. Wogonin (5,7-dihydroxy-8-methoxyflavone) is an O-methylated flavone and has attracted noteworthy appreciation because of its ability to pharmacologically target plethora of cell signaling pathways in different cancers. In this mini-review, we have gathered scattered pieces of available scientific evidence to summarize how wogonin pharmaceutically targeted Wnt/β-catenin, JAK/STAT, VEGF/VEGFR and TRAIL-driven apoptotic pathways in wide variety of cancers. We have also critically analyzed how wogonin prevented carcinogenesis and metastasis in tumor-bearing mice. Although researchers have uncovered pleiotropic role of wogonin in the regulation of different oncogenic signaling cascades but there are visible knowledge gaps in our understanding related to regulation of non-coding RNAs by wogonin. Future studies must converge on the unraveling of additional drug targets for wogonin to achieve a fuller and realistic understanding of the chemopreventive properties of wogonin.
Diagnostic value of MRI-DWI signal intensity value combined with serum PGI, PGII and CA199 in early gastric cancer
Authors: Li Minhong , Zheng GuangHui , Yu Lin , Tan Li-lian , Li Xi , Li Min-Jian , Li Chaowei , Li Shuxin , Liang Jiefeng , Zhong Zhongqi , Li Zhi Ming
Published: November 2021

To explore the diagnostic value of MRI-DWI signal intensity value combined with serum PGI. PGII and CA199 in early gastric cancer. Sixty cases of gastric cancer patients admitted to our hospital from December 2019 to December 2020 were selected as the gastric cancer group and 80 cases of healthy volunteers who underwent physical examination in our hospital during the same period were selected as the healthy group. All the 60 patients underwent MRI-DWI examination, and the pathological diagnosis results were regarded as the gold standard. MRI-DWI images, MRI-DWI signal intensity values of patients with different degrees of gastric cancer differentiation. Serum PGI, PGII and CA199 levels of subjects in the two groups were compared. AUC was used to evaluate the diagnostic value of MRI-DWI signal intensity value combined with serum PGI, PG II and CA199 for early gastric cancer. In the healthy group, T1W1 showed relatively uniform low signal intensity. While T2WI showed no significant increase in signal intensity. In the gastric cancer group. There was diffuse gastric wall thickening, local thickening or mass formation; T1WI and WATS showed slightly lower signal intensity in the lesion area. T2WI, FLAIR and B-TFE showed slightly uneven or moderately increased signal intensity. DWI showed limited diffusion, and the signal intensity increased uniformly or more uniformly, and the range of increase was clear. The signal intensity of MRI-DWI was 89.12 ± 8.14 in patients with low differentiation, 82.17 ± 6.35 in patients with moderate differentiation, and 74.52 ± 4.53 in patients with high differentiation. There were significant differences in the signal intensity of MRI-DWI among the three groups, and the difference was statistically significant (F=12.214, P <0.05). Serum PGI levels of subjects in the gastric cancer group were significantly lower than those in the healthy group, and the levels of PGII and CA199 were significantly higher than that in the healthy group, with statistical significance (P <0.05). The AUC, sensitivity and specificity of MRI-DWI signal intensity value and serum PGI, PGII and CA199 combined indexes in the diagnosis of gastric cancer were significantly higher than those of the independent indexes, with statistical significance (P <0.05). Conclusion: MRI-DWI signal strength value, serum PGI, PGII and CA199 levels are closely related to the occurrence and development of early gastric cancer. The combined detection and diagnosis efficiency is higher, which is helpful to improve the detection rate of early gastric cancer and is worthy of extensive clinical application.
Evaluation of Danzhi Xiaoyao powder and amlodipine sustained-release tablets in follow-up treatment of the hypertensive crisis and the interleukin-6 gene expression
Authors: Wei Qian , Jing Zhang , Zhi-Ye Hao
Published: November 2021

Danzhi Xiaoyao powder (DXP) is an herbal formula with eight different herbs. This herbal medicine can play multiple roles in various disease treatments through its several components. In this study, the effect of DXP was evaluated on the treatment of hypertensive patients with and without amlodipine. For this purpose, 252 patients were studied with high blood pressure. The 126 patients received DXP, and the others received DXP + amlodipine for four weeks. Besides demographic and biochemical assessments (gender, BMI, age, SBP, DBP, etc.), the expression of the interleukin-6 gene was evaluated in these two groups. The results showed that the blood pressure decreased by DPX, and there was no significant difference in control of blood pressure by DPX and DXP + amlodipine. But it did not affect interleukin-6 gene expression. Therefore, it can be concluded that this drug probably uses a different mechanism than amlodipine to control blood pressure.
Serum levels of TNF-a and IFN-g gene polymorphism in type 2 diabetes mellitus in kurdish patients
Authors: Darogha Suhaila Nafee
Published: November 2021

Type 2 diabetes mellitus (T2DM) is a metabolic disease and cytokines show a vital role in the T2DM progress. The goal of this research was to assess serum levels of tumor necrosis factor-alpha (TNF-?) and interferon-gamma (IFN-?) gene polymorphism in T2DM in Kurdish patients. Levels of serum IFN-? and TNF-? were assessed through enzyme-linked immune sorbent assay in individuals with T2DM and the control group. DNA was extracted and the amplification refractory mutational system method was utilized for genotyping the IFN-? (+874) A/T and TNF-? (-308) G/A. The Hardy–Weinberg equilibrium was evaluated with the ?2-test. The IFN- ? serum levels were significantly different between patients with T2DM and control individuals (P<0.05). But the C-reactive protein (CRP) and TNF-? serum levels were not significantly different between them (P>0.05). The serum level of IFN- ? (+874) AT genotype and TNF-? (- 308) GG genotypes were significantly higher in the T2DM group comparing with healthy people (P<0.05). A significant relation between T2DM and IFN-? (+874) gene polymorphism’s TT and AT genotypes was observed. Also, it was not a significant relation between TNF-? (?308) gene polymorphism’s GG and GA genotypes and T2DM. But the statistically significant difference was found in the genotype AA frequency. Genetic polymorphisms of IFN-? (+874) and TNF-? (?308) are contributed to the genetic susceptibility for T2DM development in the Kurdish population. Early screening of these two genetic polymorphisms may assist in the early control and management of T2DM.
Metal ion effects on Polyphenol Oxidase Covalently immobilized on a Bio-Composite
Authors: Uzunoğlu Serap Beyaztaş , Uzunoğlu Tayfun , Koçsuz Samet , Evyapan Murat , Arslan Oktay
Published: November 2021

Biosensors can be developed using different immobilization methods. Interest in immobilization methods have increased because biosensors have been important for science. Polyphenol oxidase (PPO) was used generally in biosensor applications. For this purpose, Polyphenol oxidase from banana was purified and covalently immobilized on chitosan-gelatin bio-composite. The properties of immobilized enzyme were investigated and compared to free enzyme. Various parameters were studied such as pH, temperature and storage stability on immobilized and free enzyme. Kinetic parameters were also evaluated by different substrates on immobilized and free enzyme. Catechol was determined the best substrate for immobilized enzyme with optimum condition. In vitro effects of metal ions were studied on immobilized enzyme. Concentration range of metal ions is 1.0-10.0 x10-6 mol/L. The activity of immobilized PPO was increased by Fe+2 and Ag+1 ion. Co+3 and Cu+1 had very strong inhibitory effects with IC50 values of 19.69x10-3 mol/L and 23.49 x10-3 mol/L, respectively. Inhibition constants (Ki) and inhibition types of metal ions were determined with immobilized enzyme. Zn+2 and Cr+3 ions were showed competitive inhibition and Pb+2 ions were determined non-competitive inhibition with immobilized enzyme. Mixed type inhibition was obtained with Co+3 ion using catechol as substrate with 3.33x10-5 mol/L Ki value on immobilized PPO. Immobilized PPO can be evaluated for biosensor for the purpose of measurements of metal ions.
Expression patterns of LncRNA-GAS5 and its target APOBEC3C gene through miR-103 in breast cancer patients
Authors: Kanabe Belan O. , Ozaslan Mehmet , Aziz Sherwan Ahmed , Al-Attar Mustafa S. , Kılıç İbrahim Halil , Khailany Rozhgar A.
Published: November 2021

Early diagnosis of breast cancer can increase the survivability of the patients and the patient’s quality of life. There is growing evidence demonstrating the active role of LncRNA-GAS5 and miR-103 in cancer biology. APOBEC enzymes are important players in immunity and may contribute to carcinogenesis. Mutation and expression alteration in the APOBEC gene family was found to have a strong correlation with breast cancer risk. This study aimed to evaluate the expression level of lncRNA-GAS5 and its target APOBEC3C in women with breast cancer through expression evaluation of miR-103. Moreover, the interaction between lncRNA-GAS5 and miR-103 was studied. In the present study, forty paired tumor and normal samples classified based on breast cancer subtypes and clinical features of patients were analyzed using gene expression studies. Immunohistochemical analysis of the gene products was performed to classify tumors. The RNA samples were extracted from breast tissue. Real-time PCR was conducted for APOBEC3C and Lnc-RNA GAS5 expression. In addition, miR-103a miScript Primer Assay was utilized for the expression of miR-103-5p. It was revealed that the expression level of APOBEC3C and lncRNA-GAS5 were significantly down-regulated; however, the miRNA-103 expression level was significantly up-regulated. GAS5 expression was positively correlated with APOBEC3C expression and negatively correlated with miR-103 expression. In conclusion, we observed down-regulation of APOBEC3C and LncRNA-GAS5 and up-regulation of miRNA 103 in breast cancer patients. The expression of GAS5 may provide a new potential treatment target for breast cancer. To clarify the role of these molecules in the cellular signaling pathways, further studies are required.
Investigation of gene expression and genetic simultaneous control associated with erectile dysfunction and diabetes
Authors: Kazemi Elham , Zargooshi Javaad , Kaboudi Marzieh , Izadi Fereshteh , Mohammadi Motlagh Hamid-Reza , Kahrizi Danial , Khazaie Habibolah , Mahaki Behzad , Mohammadian Youkhabeh
Published: November 2021

Diabetes can cause some diseases or abnormalities. One of the disorders caused by diabetes may be erectile dysfunction (ED). ED is sexual dysfunction characterized by the inability to establish or maintain an erect penis during sexual activity and is a complication of men with chronic type 2 diabetes. These processes, disorders and diseases are highly influenced by the genetics of individuals. In this study, the relationship between genes and diabetes and ED has been explored by a system biology approach. For this purpose, the samples from ten control and diabetic-ED rats were collected. After a search in Gene Expression Omnibus (GEO), series with accession number GSE2457 comprising of 5 normal and 5 diabetic-ED rats were selected. Raw CEL files of these samples were normalized with robust multi-array average (RMA) expression measure method by using the linear models for microarray data (LIMMA) R package. The extracted probe IDs were transformed into 10451 unique and validated official gene symbols. Then, differentially expressed genes (DEGs) were identified between control and normal mucosa by employing the LIMMA R package. DEGs were classified by utilizing KEGG to underlying pathways by Enrichr. The expression values of DEGs were used to construct a gene regulatory network (GRN), by the GENEI3 R package. To analyze the topology of constructed GRNs, betweenness centrality was calculated. Genes with higher betweenness centrality scores were then identified, through the CytoNCA. We then took the commonality of DEGs genes and high-top ranking genes from CytoNCA via a predicted interaction network using GeneMANIA as the most likely important genes in erectile dysfunction. Among the 374 DEGs studied, 146 DEGs showed up-regulation and 228 DEGs displayed down-regulation expression in diabetic-ED rats. According to the Volcano plot, the dpp4, LOC102553868, Ndufa412, Oxct1, Atp2b3 and Zfp91 gene down-regulated and Lpl, Retsat, B4galt1 and Pdk4 genes up-regulated in ED and diabetic rats. Furthermore, genes like dpp4 acted as hubs in the inferred GRN.
Zu den Konsulnfasten der Zeit des Antoninus Pius. Konsequenzen aus einem neuen Militärdiplom
Authors: Eck Werner , Pangerl Andreas
Published: November 2021

A new military diploma for the province Dalmatia mentions the pair of suffect consuls Q. Antonius I[sauricus, L. Aurelius Flaccus], known from the Fasti Feriarum Latinarum for May of an unknown year. Till now this pair was dated to the first years of Antoninus Pius, no later than 144 AD. But since in the diploma in the emperor’s title cos. IIII = 145 AD is mentioned, this is excluded. It seems that the suffect consuls can be dated only to one of the last years of Pius, either in 156 or 157, because in all the other years the consuls of the relevant months are known.
ROSYJSKI TRZECI SEKTOR WE WSPÓŁCZESNEJ FEDERACJI ROSYJSKIEJ
Authors: Lachowicz Marta
Published: November 2021

At present, Russian Federation shows symptoms of departure from democratization processes and civil society models. Over the last decade, Vladimir Putin’s coming to power, changes in the strategy and rhetoric of internal affairs in demonstrated tendencies for increased social control, restrictions imposed on NGOs and deliberate restructuring of the third sector in line with the designs of the central authority.
Religijny wymiar aktywności społecznej w protestanckim środowisku łódzkich przemysłowców w XIX-XX w. Na przykładzie rodzin Scheiblerów, Herbstów i Geyerów
Authors: Woźniak Krzysztof Paweł
Published: November 2021

The article outlines the outcomes of social activities undertaken by the elites of Protestant industrialists of Łódź in the 19th and 20th century, highlighting the religi­ous motivations behind their initiatives. The author draws attention to the correlation between the Protestant worldview and ethics and the demands of the nascent capitalism, in the circumstances where the state failed to address the numerous social problems of the times.
Severan Books of Cassius Dio’s Roman History (LXXIV-LXXX) and their Byzantine Epitomators
Authors: Biały Kamil
Published: November 2021

Severan Books of Cassius Dio’s Roman History (LXXIV-LXXX) and their Byzantine Epitomators
Foreign language peace of mind: a positive emotion drawn from the Chinese EFL learning context
Authors: Zhou Li , Dewaele Jean-Marc , Lochtman Katja , Xi Yiheng
Published: November 2021

This study presents a new positive emotion construct, 外语平和心态 (waiyu pinghe xintai) or Foreign Language Peace of Mind (FLPOM), drawn from the Chinese cultural tradition. It is a low-arousal positive (LAP) emotional state (e.g., calmness, peacefulness) and a state of internal harmony. Three sub-studies were conducted. In Study 1, a measurement scale of FLPOM was developed and validated. In Study 2, the FLPOM scale was administered to Chinese English as a Foreign Language learners along the Chinese Foreign Language Enjoyment (FLE) scale which can potentially reflect slightly more high-arousal positive (HAP) states (e.g., joy, enthusiasm) to test the discriminability of FLPOM from FLE. Study 3 examined the extents to which FLPOM and FLE predict Chinese learners’ language proficiency. Correlation and discriminant validity analysis confirmed that FLPOM and FLE were related but discriminable emotion constructs. Stepwise regression analyses revealed that FLPOM was a stronger predictor of Chinese learners’ self-perceived FL proficiency than FLE. Possible implications on FL teaching and learning in the Chinese context were provided.
Wigalois am Rande des Paradieses
Authors: Mierke Gesine , Schanze Christoph
Published: November 2021

This essay deals with the illustrated Leiden codex of Wirnt von Grafenberg’s Arthurian novel ›Wigalois‹ (Leiden, University Library, Ltk 537). We will show that, in the interplay of text and picture, the codex is meant to privilege a certain interpretation of the novel text, which is a salvatory reading of ›Wigalois‹. We base our examination on the two illustrated pages opening the codex, which shape the visual language of the entire illustration cycle. In addition, this illustration cycle has the function of further emphasising some of the novel’s central scenes and clarifying their potential of meaning. The last illustrated page of the codex integrates the Dukes of Braunschweig-Grubenhagen as patrons of the manuscript into the illustration programme, and provides a back reference ranging from the history of salvation to world history as well as local history.
A new iteration method for the solution of third-order BVP via Green's function
Authors: Akgun Fatma Aydın , Rasulov Zaur
Published: November 2021

In this study, a new iterative method for third-order boundary value problems based on embedding Green’s function is introduced. The existence and uniqueness theorems are established, and necessary conditions are derived for convergence. The accuracy, efficiency and applicability of the results are demonstrated by comparing with the exact results and existing methods. The results of this paper extend and generalize the corresponding results in the literature.
Effects of geometric parameters on volumetric mass transfer coefficient of non-Newtonian fluids in stirred tanks
Authors: Ali Haider , Zhu Sofia , Solsvik Jannike
Published: November 2021

Scaling up stirred tanks is a significant challenge because of the research gaps between laboratory and industrial-scale setups. It is necessary to understand the effects of scale-up on the mass transfer in stirred tanks, and this requires meticulous experimental analysis. The present study investigates the effects of tank size and aspect ratio (

H
L

T

$\sfrac{{H}_{L}}{T}$

) on the volumetric mass transfer coefficients of shear-thinning fluids. The experiments were conducted in three stirred tanks of different sizes (laboratory and pilot scale) and geometries (standard and nonstandard).

H
L

T

$\sfrac{{H}_{L}}{T}$

was 1 for the standard tanks and 3.5 for the nonstandard stirred tanks. Three sizes of stirred tanks were used: 11 L with

H
L

T

$\sfrac{{H}_{L}}{T}$

of 1, 40 L with

H
L

T

$\sfrac{{H}_{L}}{T}$

of 3.5, and 47 L with

H
L

T

$\sfrac{{H}_{L}}{T}$

of 1. Impeller stirring speeds and gas flow rates were in the range of 800–900 rev min−1 and 8–10 L min−1, respectively. The volumetric mass transfer coefficient was estimated based on the dissolved oxygen concentration in the fluids, and the effects of rheology and operating conditions on the volumetric mass transfer coefficient were observed. The volumetric mass transfer coefficient decreased as tank size increased and increased with an increase in operating conditions, but these effects were also clearly influenced by fluid rheology. The impacts of scale-up and operating conditions on the volumetric mass transfer coefficient decreased as liquid viscosity increased.
New Mainstream Films and Television Dramas in China: The Construction of Industrial Aesthetics and Consumption of Youth Culture
Authors: Chen Xuguang
Published: November 2021

As a significant industrial and cultural phenomenon, the rise of new mainstream films and TV dramas in China embodies the inclusion of multiple cultures (mainstream culture, grassroot culture, youth culture, etc.) and the respect for diverse audiences. In particular, such trends bring into focus the youth market and explore the image-based expression of youth culture, subculture and fashion culture. However, this author argues that the production of such films and TV dramas also needs to further pursue market-orientated strategies, sustainable development, and conformity to industrial standards. In short, the production of new mainstream films and TV dramas should not revert to the previous production pattern of mainstream films.
Cervantes y el montaje de sus comedias
Authors: González Aurelio
Published: November 2021

En el hecho teatral hay una doble textualidad: dramática y espectacular. Tomando esto en cuenta, el dramaturgo controla el posible montaje de su obra en las acotaciones en el texto dramático ya que estas son indicaciones explícitas sobre la idea que tiene el autor de la puesta en escena de su obra. En estas páginas se revisan las acotaciones de Cervantes y se pone de manifiesto su conocimiento de la mecánica teatral y del espacio escénico de su tiempo, así como su actitud de director de escena.
Editorial: Contabilidad crítica en Latinoamérica: trayectorias, interacciones y conversaciones entre el Norte y el Sur.
Authors: Gómez-Villegas Mauricio , Ocampo-Gómez Elizabeth , Neu Dean
Published: November 2021

El número especial busca reunir, visibilizar y difundir esfuerzos intelectuales que la comunidad contable crítica latinoamericana está realizando, para problematizar, comprender e intervenir nuestra realidad organizacional y social contextual. Pero, al mismo tiempo, pretende contribuir al diálogo, al debate y a la reflexión sobre el campo de lacontabilidad crítica entre académicos del Sur y del Norte.
Tres discursos sobre los modos de regulación del capital y su relación con el concepto de lo público en las empresas de servicios públicos de Bogotá
Authors: Díaz Montaño Evelyn Ivonne , León Paime Edison Fredy
Published: November 2021

El objetivo del presente documento es explicar la dinámica de construcción y circu- lación de discursos sobre las formas de regulación de capital con relación al concepto de “lo público” en las empresas de servicios públicos (ESP) de la ciudad de Bogotá. El objeto es comprender la manera en que estas instituciones han servido de dispositivos de gubernamentalidad a partir de tres discursos: modernización, bienestar y planificación. Metodológicamente, el estudio recurrió a dos estrategias de investigación social, el análisis documental y el análisis del discurso de 94 documentos institucionales. Como resultado, se identificó que la imposición de los discursos configuró una estrategia histórica de las élites locales para mantener el control de las ESP en función de sus propios intereses. Así, fenómenos como la privatización y la estatización son esquemas de la misma dinámica funcional.