bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge, attitude, and practice of healthcare providers and clients toward child abuse in Tabriz
Authors: Farahbakhsh Mostafa , Shahrokhi Hassan , Norouzi Sanaz , Moshfegh Mahtab , Malja Basiri Hasna , Harzand-Jadidi Sepideh
Published: June 2024

Background. Child abuse is considered a major public health issue worldwide. The knowledge and attitudes of parents and health service providers are of great importance in the prevention and control of child abuse. Therefore, this study was conducted to investigate the knowledge, attitudes, and performance of healthcare providers (HCPs) and healthcare clients (HCCs) regarding child abuse in Tabriz. Methods. This cross-sectional study was performed among 445 HCPs and 390 HCCs in Tabriz in 2021. The samples were selected via random sampling methods, and the information was gathered through a researcher-made questionnaire. In this study, knowledge, attitudes, and performance were considered dependent variables, and demographic variables were regarded as independent variables. Multiple linear regression was used to evaluate the association between dependent and independent variables. The data were analyzed using Stata statistical software (version 17). Results. The mean score of the knowledge, attitudes, and performance of HCPs was 73.2, 87.89, and 85.12, respectively. The mean score of knowledge, attitudes, and performance of HCCs was 58.81, 64.3, and 48.18, respectively. The knowledge and performance of HCPs had a significant relationship with passing a training course in the field of child abuse, jobs, and education, so that passing the training course increased the knowledge score by 3.33 units. In addition, the knowledge and attitude of HCCs were significantly associated with gender, education, and marital status, so that the knowledge score of people with postgraduate education was 8.03 units higher than that of those having a diploma. Conclusion. Overall, the knowledge, attitude, and performance of HCPs toward child abuse were favorable. Therefore, they may have a high potential for detecting child abuse and developing preventive initiatives. Additionally, considering the medium level of knowledge and performance of HCCs toward child abuse, it seems necessary to design family education programs for future parents and launch community-based support services in health centers to prevent child abuse. Practical Implications. The findings of this study can be presented to the policymakers of the Ministry of Health to provide an opportunity to improve the knowledge, attitude, and performance of HCPs and HCCs by developing national guidelines for dealing with child abuse.
Evaluation of expression levels of Micro-RNA-378, Micro-RNA -103, and Micro-RNA-497 in melanoma
Authors: Aslani Faria , Abdolrahimi Zohreh , Ghasembaglou Shahram
Published: June 2024

Background. The aim of this study was to investigate the relative changes in the expression levels of these genes in melanoma tumor samples. Methods. During this study, 40 tumor samples and 40 samples of marginal tissue around the tumor were collected as control samples. After collecting RNA, the samples were extracted and the expression of the desired gene was evaluated using real-time polymerase chain reaction. Differences in the expression levels of the three groups were assessed by appropriate statistical tests. In statistical tests, P<0.05 was considered significant. Results. The expression level of all three genes in the tumor samples was significantly different from marginal samples. In addition, the genes were significantly associated with patients’ clinical features such as metastasis and lymph node involvement. Conclusion. Our findings revealed that microRNA expression can be used as a pathological biomarker in melanoma. However, it is better to perform more research in this regard among different communities with larger sample sizes. Practical Implications. This biomarker is effective in the early diagnosis of melanoma, causing higher survival rates in patients.
The effect of physical activity along with the consumption of hydroalcoholic extract of date pollen on the expression of some microRNAs in cadmium-induced toxicity in rat kidney tissue
Authors: Delshad Amir , Salimi Fereshteh , Valipour Saeed
Published: June 2024

Background. This study aims to determine the combined effect of physical activity and the hydroalcoholic extract of palm pollen on the expression of mir-21 and mir-132 in cadmium-induced toxicity in the kidney tissue of male rats. Methods. In this study, 48 adult and healthy male Wistar rats with a weight range of 250 ± 30 grams and 12 weeks of age were randomly divided into 6 groups: 1) control, 2) exercise, 3) cadmium, 4) cadmium + exercise, 5) cadmium + palm 200 + exercise, 6) cadmium + exercise + palm 400. All groups received three milligrams per kilogram of body weight of cadmium chloride daily by gavage, and palm pollen extract was injected intraperitoneally with doses of 200 and 400 mg of body weight. Aerobic training started with rats running on a treadmill at a speed of 27 meters per minute for 16 minutes, and one minute was added to the training every day. Results. The results showed that there is a significant difference in the expression of miR-21 between the groups (P=0.001), with cadmium causing a decrease and aerobic exercise and receiving palm pollen extract leading to a significant increase in the miR-21 gene expression (P=0.005). Also, there is a significant difference in the expression of miR-132 between the groups (P=0.04), indicating that cadmium decreased this variable when compared to the control; however, the combined effect of exercise and palm pollen administration was not statistically significant (P=0.98). Conclusion. Our study showed that performing moderate-intensity regular exercise along with palm pollen in cadmium-treated mice upregulated microRNAs associated with kidney toxicity. Practical Implications. The combined effect of the proposed herbal supplement and physical activity can control the harmful effects of exposure to cadmium on industrial societies and chemical industry workers to some extent.
The Effect of Sexual Assertiveness Training on Marital Satisfaction and Happiness of Azari Women: A Semi-experimental Study
Authors: Sattarzadeh Jahdi Nilufar , Hakimi Sevil , Shakibaeefar Mahtab
Published: June 2024

Background. Sexual assertiveness is defined as a psychosocial feeling about an individual’s interpretation of how to express her/her feelings in marital relationships. The present study aimed at investigating the effect of sexual assertiveness training on marital satisfaction and happiness of women referring to Tabriz health centers in 2021. Methods. This semi-experimental study was conducted on 66 women of reproductive age, referring to the health centers in Tabriz, Iran. The participants who obtained a Hulbert sexual assertiveness score of less than 33 were randomly assigned to control and intervention groups. The data were collected using an eligibility checklist (inclusion/exclusion criteria), a demographic characteristics questionnaire, the Halbert Index of Sexual Assertiveness (HISA), the Larson Sexual Satisfaction (LSS) scale, and the Marital Happiness Scale (MHS). The educational intervention of HISA was held in three sessions lasting 60-90 minutes. Eventually, the participants completed HISA, LSS, and MHS questionnaires before and after the intervention. Results. The findings of the present study indicated a significant difference between the mean scores of HISA, LSS, and MHS in the post-intervention stage between the two groups (P=0.001). Conclusion. Given the positive effect of sexual assertiveness training on women’s sexual satisfaction and marital happiness, it is recommended that these simple and low-cost educational interventions be considered to improve the mental and sexual status of women. Practical Implications. Sexual assertiveness education program improved sexual satisfaction and marital happiness. It is recommended to apply these simple and low-cost educational interventions to improve the mental and sexual status of women.
Investigating TE effects on the relationship between signal intensity and PVP-grafted SPION concentration in T2-weighted Spin Echo imaging
Authors: Nazarpoor Mahmood , Fattahi Hassan
Published: June 2024

Background. Because ionizing radiation and radioactive materials are not used in MRI images and their good spatial resolution, it has been widely used in the diagnosis of diseases. But for a more accurate diagnosis of some diseases, it is necessary to inject contrast material. Contrast materials are metal ions of paramagnetic elements such as gadolinium (Gd) or superparamagnetic iron oxide nanoparticles (SPIONs). This study aims to investigate the effect of echo time (TE) on the signal intensity of PVP-grafted iron oxide nanoparticles on spin echo T2-weighted images as a negative contrast material (T2-contrast). Methods. Prepared nanoparticles (SPIONs grafted with PVP) in different concentrations (0-0.600 μmol Fe/L) that were poured inside the test tubes were spin echo T2-weighted imaged by an MRI scanner (1.5 T). Results. The curves of nanoparticle concentration versus the signal intensity show that with increasing nanoparticle concentration, the signal intensity decreases. Also, at a constant TE, the higher nanoparticle concentration has lower signal intensity. Conclusion. The produced nanoparticle (PVP-grafted iron oxide nanoparticles) can be used in clinical work as a negative contrast material due to the behaviour it showed in different concentrations and TE. Practical Implications. Nanoparticles are used as a contrast agent in MRI imaging. The results of this study show that the prepared contrast agent can be used as a negative contrast agent in clinical imaging.
Investigating the all-red-light violation and the increase in front-to-side crashes at signalized intersections
Authors: Sadeghi-Bazargani Homayoun , Hazegh Ehsan , Afshari Abolfazl , Asadi Anbardan Mohammad , Yazdani Mirbahador
Published: June 2024

Background. Red-light violations (RLV) cause thousands of injuries and fatalities annually. All red lights are when all the traffic lights are red and require the evacuation of the intersection. In Iran, drivers disregard their approach’s signals, leading to serious front-to-side collisions. This study examined the violation relationship with traffic parameters and presented strategies for preventing front-to-side crashes at signalized intersections. Methods. Field data from 11 signalized intersections in Tabriz with a total of 27 approaches and various traffic and geometric characteristics were used for this study in order to determine factors influencing all RLVs. Results. The findings indicated that the risk of all RLVs increased with the red-light time variable in each approach. In addition, the risk of all RLVs was greater when the width of the approach and the number of vehicles in the first queue were lower. The variable of the left-turn type was also significant in the model and demonstrated that if the left-turn type is permitted, the risk of all RLVs would be higher. Conclusion. The results of this study can be used to prioritize the installation of cameras for crossing the stop line during red lights at intersections. Practical Implications. The location of adjacent traffic lights and pedestrian signal lights should be designed in such a way that they are not in the direct view of drivers and that they do not follow the changes in the adjacent approach traffic lights and start moving when the approach light turns green.
Designing and Evaluation of a Multiepitope Vaccine against Avian Newcastle Disease Virus, Influenza Virus and Infectious Bronchitis Virus
Authors: Ghandadi Morteza
Published: June 2024

Background: Poultry industries play an important role in the human food supply. Newcastle disease virus (NDV), Infectious bronchitis virus (IBV), and Avian influenza virus (AIV) can cause epizootic outbreaks in poultry industries and lead to extensive economic losses. Furthermore, these viruses can also infect wild birds, and avian influenza virus is a serious threat to humans. Here, a multiepitope vaccine has been designed to induce an immune response against IBV, NDV, and AIV using extensive bioinformatics tools. Methods: To do so, the antigenic proteins, including the hemagglutinin of H5 and H7 subtypes of AIV, nucleocapsid and spike proteins of IBV, and fusion and hemagglutinin-neuraminidase proteins of NDV, have been studied to find immunodominant epitopes with MHC-I/MHC-II binding potential. Four antigenic and non-allergenic epitopes from each antigenic protein were connected to avian beta-defensin 1 as an adjuvant to construct the multiepitope vaccine. To investigate the potential of vaccine-induced activation of toll-like receptors (TLR-2, 5), the tertiary structure of the vaccine was modeled and docked to TLR-2/5 proteins. Results: Evaluation of the physicochemical properties of the vaccine construct has demonstrated the stability and solubility of the vaccine upon overexpression. The vaccine construct demonstrated antigenicity and was specified as a non-allergenic protein. The vaccine can induce significant cellular and humoral immune responses, and TLR proteins can recognize the vaccine in its three-dimensional form. Conclusion: Overall, the multiepitope vaccine designed in the present study against IBV, NDV, and AIV shows significant immunological potential that should be further investigated in wet laboratory experiments.
Evaluation of Circ-Nrf2s Expression on Oxidative Stress Condition and Prediction Its Interaction with mi-RNAs and Proteins
Authors: Amini Javad , Arezumand Roghaye , Sanadgol Nima , Alesheikh Peyman
Published: June 2024

Background: Circular RNAs (Circ RNA) are a large class of non-coding RNAs which particularlystable RNAs and mostly originate from gene exons in animals. circRNAs are extremely abundantin the mammalian brains. They play role in the biological function and development of neurons.Nrf2 (nuclear factor erythroid 2–related factor 2) is a transcription factor that regulates cellularantioxidants and improves hippocampal synaptic plasticity, learning and memory. The aim ofthis study is the evaluation of Nrf2’s circRNA expression in the hippocampus of rats duringoxidative stress and the prediction of their function by bioinformatic tools. Methods: After evaluation of Nrf2’s circRNA prediction from circAtlas by BLAST, 3 out of 4sequences with high homology were selected and circ-Nrf2s expression was evaluated by qPCR,the interaction with micro RNAs and proteins was evaluated by miRDB, TargetScan, catRAPIDand HDOCK web server. Except control group, two groups of rats were treated with H2O2 (1%and 5%) then rats were sacrificed and hippocampal tissue was separated. qPCR was performedfor Nrf2 pathway gene expression and Nrf2 circRNAs. Then Circ-Nrf2-miRNA and 2circ-Nrf2-protein interaction were evaluated. Results: The most important circRNA that origin from Nrf2 is circ-Nrf2-1. Circ-Nrf2-1downregulates in oxidative stress and upregulates in 5% of H2O2 compared to 1%. However,linear Nrf2 was upregulated in both 1% and 5% H2O2. Circ-Nrf2-1 can bind to several miRNAsincluding miR-144-3p, miR-148a-5p, miR-155-5p. It also interacts with Celf1 which plays a rolein oxidative stress. Conclusion: According to results, it is plausible to suggest that circNrf2 may play a regulatoryrole in modulating oxidative stress.
Modern In Silico Molecular Docking Perspective for Investigation of Rindera lanata Bunge var. lanata targeting: Phytochemical Profile, Phytotoxicity and Bioactivity Assays
Authors: Ghanbari Hadi , Hamedeyazdan Sanaz , Ghanbari Reza , Alilou Mostafa , Delazar Abbas , Nejad Ebrahimi Samad , Nazemiyeh Amirreza , Memar Mohammad Yousef , Nazemiyeh Hossein
Published: June 2024

Background: Finding herbal herbicides with biodegradability and selectivity against weeds is an interesting and vital challenge for human health. The study was considered to analyze the phytochemical profile, phytotoxicity and biological activities of Rindera lanata together with a molecular docking perspective. The study was considered to analyze the phytochemical profile, phytotoxicity and biological activities of Rindera lanata together with a molecular docking perspective. Methods: Aerial parts of R. lanata were successively solvent extracted with the Soxhlet apparatus, followed by maceration. Different chromatography methods were employed to isolate and purify the major compounds of the plant. The compounds were assigned by spectroscopic methods, containing 1D and 2D NMR (Nuclear Magnetic Resonance). Several in vitro antioxidant assays, together with an antimicrobial assay, alongside the allelopathic property on the germination of Cuscuta campestris seeds, were assessed upon the extracts. As a final point, molecular docking was conducted to evaluate the interactions among the identified compounds with 4-hydroxyphenyl pyruvate dioxygenase (HPPD), glutamine synthetase (GS), and acetohydroxyacid synthetase (AHAS). Results: Phytochemical analysis of the extracts led to the identification of a new flavonoid 3, 5, 4’-tri-O-methylquercetin (1), apigenin (2), chrysoeriol (3), luteolin-7-O-glucoside (4) and rutin (5). It was exposed that ethyl acetate extract not only illustrated the highest antioxidant effect in all the in vitro assays but also exhibited the maximum antibacterial effect against Staphylococcus epidermidis. Effectively, it showed conventional allelopathic activity in preventing germination, seedling length and seedling weight growth of C. campestris seeds, as well as a concentration-dependent enhancement (p≤0.05). Docking analysis results indicated that rutin had a good affinity for HPPD, GS and AHAS enzymes, with docking score values of -11.454, -10.422 and -10.152 kJ/mol, respectively. Conclusion: The present study suggested that isolated flavonoids from R. lanata could be used as the lead compounds in the development of natural herbicides for strong bonds in the active region of HPPD, GS and AHAS enzymes.
Synthesis, Docking and Acetylcholinesterase Inhibitory Evaluation of 1,3,4-Thiadiazole Derivatives as Potential Anti-Alzheimer Agents
Authors: Mohammadi-Farani Ahmad , Takesh Milad , Mohammadi Mahsa , Hosseini Amin , Aliabadi Amin , Aliabadi Alireza
Published: June 2024

Background: According to the cholinergic hypothesis for Alzheimer’s disease, potentiation of cholinergic neurotransmission is one of the best strategies for combating dementia. Methods: A new series of benzamide derivatives bearing 1,3,4-thiadiazole nucleus were synthesized and subsequently, their anticholinesterase activity was evaluated. Molecular docking was carried out to explore the likely binding mode and interactions. Results: Fortunately, some of the tested compounds exhibited more activity than donepezil as a reference drug (IC50 = 0.6 ± 0.05 µM). Some of the evaluated derivatives displayed potency in the nanomolar range. Compound 7e with fluorine atom on the meta position of the phenyl ring was the most active compound in this series (IC50 = 1.82 ± 0.6 nM). Conclusion: The 1,3,4-thiadiazole derivatives that were synthesized and tested in the current manuscript demonstrated remarkable anticholinesterase activity. Therefore, these compounds could be suggested as potential anti-Alzheimer agents.
Jojoba Oil Hastens Dexamethasone Induced Delayed Wound Healing: A Preclinical Study
Authors: Begum Farmiza , Kotian Pooja J , Hiremath Snigdha , Ramdasi Atharva , Sharma Apoorva , Beegum Fathima , Gurram Prasada Chowdhari , Nampoothiri Madhavan , Krishnadas Nandakumar , Shenoy Rekha R
Published: June 2024

Background: Wound healing is a complex, multifactorial process in which poor healing in chronic wounds has emerged as the most significant complication in recent years. Jojoba oil (JO) has been traditionally used for its medicinal properties, especially for skin disorders. Studies suggested its potential wound-healing activity in-vitro. However, the underlying mechanism by which JO promotes the rejuvenating process is unclear in-vivo. The present study was aimed at evaluating the wound-healing activity of JO in both normal and delayed healing. Methods: Excision wounds were inflicted by surgical method on the anesthetized rats. Animal wounds were explored for their healing activity by photography in-vivo. Expression of ERK, collagen, VEGF and PDGF was investigated using western blot. Results: Topical administration of JO (0.5 ml/wound, twice a day) showed significant wound healing activity. All groups demonstrated a significant increase (p<0.001) in wound contraction percentage except dexa+JO versus control. 100% wound closure was seen on day 12 in JO treated group when compared to the control which showed complete closure on day 15. We found that JO-treated animals showed an increase in the expression of collagen, VEGF, PDGF and ERK whereas dexamethasone displayed no expression. In the histopathology and Masson trichrome staining, the control group showed granulation tissue with no scab and epithelium, dexamethasone group exhibited the presence of less granulation tissue when compared with the control and treatment groups. The JO group depicted mature granulation tissue with more epithelial growth and the dexa+JO group, showed granulation tissue with little epithelial growth when compared, with the JO group. Masson trichrome staining showed matured collagen in the JO group when compared with the diseased group. Conclusion: These findings suggest that JO activates ERK signaling, collagen formation, VEGF, PDGF expression which shows the plausible potential of JO in accelerating the healing process, more efficiently in delayed wound healing.
URGENSI SELF-ACCEPTANCE MAHASISWA BROKEN HOME DALAM MENINGKATKAN PRESTASI AKADEMIK
Authors: Untung Pebe , Natalia Natalia , Samsi Jumintor
Published: June 2024

Abstract : Self-acceptance is a state in which an individual has a positive view of himself so that he can accept all the advantages and shortcomings and feel satisfied with himself. Self-acceptance enables the individual to live with the characteristics that are in him and remain positive about himself. The aim of this study is to describe the importance of self-acceptance in broken home students in improving academic achievement. The method used in this research is a qualitative phenomenological method using semi-structured interviews. The informants in this study were selected with purposive sampling techniques. The results show that broken home students can survive split family conditions because they have good self-acceptance so that even if the two parents are no longer together, they can still perform by achieving a good performance index.
Abstrak: Self-acceptance suatu keadaan dimana individu memiliki pandangan positif terhadap dirinya sehingga dapat menerima segala kelebihan dan kekurangannya serta merasa puas atas dirinya. Self-acceptance memampukan individu untuk hidup dengan karakteristik yang ada dalam dirinya dan tetap memandang positif dirinya sendiri. Tujuan dari penelitian ini adalah untuk mendeskripsikan pentingnya self-acceptance (penerimaan diri) pada mahasiswa broken home dalam meningkatkan prestasi akademik. Metode yang digunakan dalam penelitian ini adalah metode kualitatif fenomenologi menggunakan wawancara semi terstruktur. Informan dalam penelitian ini dipilih dengan teknik purposive sampling. Hasil penelitian menunjukkan bahwa mahasiswa broken home dapat bertahan hidup dengan kondisi keluarga yang terpecah karena memiliki self-acceptance yang baik sehingga walaupun kondisi kedua orang tua tidak lagi bersama namun mereka dapat tetap berprestasi dengan meraih indeks prestasi yang baik.
Hiranetis vanderheydeni sp. nov. (Hemiptera: Reduviidae: Harpactorinae), an example of how a superficial evaluation may impair the taxonomy
Authors: Gil-Santana Hélcio R.
Published: June 2024

Hiranetis vanderheydeni sp. nov. (Hemiptera: Heteroptera: Reduviidae: Harpactorinae) is described from Brazil based on females and male specimens. This species, from Brazilian Atlantic Forest, has remained undescribed for at least about a century, because of two previous mistakes involving the taxonomy of species with similar general aposematic coloration.
Presence of Rhodnius neglectus Lent, 1954 (Hemiptera: Reduviidae: Triatominae) in Araraquara, São Paulo, Brazil: signals the importance of surveillance for the municipality
Authors: Santos Santana Jociel Klleyton , Belintani Tiago , Aristeu da Rosa João , de Oliveira Jader
Published: June 2024

Several publications have reported the occurrence of triatomines in urban areas of the Americas. Four species of triatomines are reported in the municipality of Araraquara, São Paulo, Brazil: Panstrongylus megistus, Rhodnius neglectus, Triatoma infestans, and T. sordida. Although already notified to the municipality, we present the record of household invasion by R. neglectus in urban area in the Araraquara. This occurrence reinforces the concern over urbanization by R. neglectus in the state of São Paulo, with reports of colonization and home invasion in various municipalities.
Havacılık İşletmeciliğine Yönelik Halkla İlişkiler Konusunda Yazılan Lisansüstü Tezlerin İncelenmesi
Authors: Ayan Altan
Published: June 2024

Özet
Çalışmada ilk olarak halkla ilişkiler kavramı ifade edilmiştir. Daha sonra havacılık işletmeciliği ile ilgili halkla ilişkiler konusundaki lisansüstü tezler çeşitli kriterlere göre değerlendirilmiştir. Araştırmanın amacı, havacılık işletmeciliği ile ilgili halkla ilişkiler kapsamında yazılan lisansüstü tezleri çeşitli kriterlere göre incelemektir. Çalışmada Ulusal Tez Merkezinin web sitesinden veriler elde edilmiştir. Çalışmada havacılık işletmeciliği ile ilgili halkla ilişkiler kapsamında yazılan 63 lisansüstü teze ulaşılmıştır. Lisansüstü tezin türü, enstitü türü, yıl, üniversite, tezin başlığı, anabilim dalı, tez danışmanının unvanı, tezlerin devlet ve vakıf üniversitelerine göre dağılımı, tezin yazıldığı dil ve tezin sayfa sayısına göre inceleme yapılmıştır.
A proposed E-PoV consensus to attain resilience of power grid framework from cyber attacks
Authors: Saxena Rashi , Kumari P. Lalitha Surya
Published: June 2024

In recently, the blockchain has grown in prominence, but studies have concentrated on its underlying consensus mechanisms. The majority of the present consensus mechanism study focuses on public blockchains but is based on advanced distributed algorithms or consensus algorithms which are currently in use. On the consortium blockchain, many different application scenarios have been created, however few researchers focus on bespoke consistency algorithms. Furthermore, while building consensus procedures, security and performance must be traded off. Proof of Vote (PoV) is the name given to the efficient voting-based consensus algorithm disclosed in this paper.With the fundamental concept of creating distinct security identities for network nodes, PoV distinguishes among voting & bookkeeping rights. EPoV is an effective voting-based consensus algorithm that we propose in our paper. We change the gaps in PoV to Extend PoV, as required by the power grid system model. The comprehensive and in-depth final result aims to expand on current knowledge of PoV’s possible applications and open up new research directions
Intraday regime switching volatility dynamics of bitcoin liquidity
Authors: Koy Ayben
Published: June 2024

Technological developments are followed in the form of speed and new products in the large ﬁnance ecosystem. Particularly, we can easily observe the increasing importance of both new products and speed in the cryptocurrency markets. Examining the liquidity in cryptocurrency markets, which are open 24 hours a day, 7 days a week, draws attention as an important issue. Liquidity, in simple terms, refers to the ease of converting a ﬁnancial instrument into cash. Bid-ask spread of a ﬁnancial instrument is also considered as a measure of liquidity. This study employs Markov switching GARCH (MSGARCH) models to investigate the intraday volatility of the liquidity of Bitcoin under low volatile and high volatile regime periods. The study analyses the 5 minutes’ intraday bid-ask spread by different types of MSGARCH models with different numbers of regimes. The analysed period 01.01.2019 – 06.29.2021 contains 52,548 observations. The ﬁrst results of the study provide evidence that low and high volatility periods can be explained by different models such as MS EGARCH, MS TGARCH, and MS GJRGARCH. Secondly, the two-regime MSGARCH and MS GJR GARCH models are the best models for explaining low and high volatility periods of intra-day Bitcoin liquidity.
Dynamic Response of Steel Structure with Bracings and Translational Tuned Mass Dampers
Authors:   Department of Civil Engineering, Bangalore University, Bangalore (Karnataka), India., Naveena K N  , Dr. Chetan K  ,   Department of Civil Engineering, Bangalore University, Bangalore (Karnataka), India.
Published: June 2024

In this work the dynamic response of steel structure with Bracings and Translational Tuned Mass Damper (TTMD) are studied. TTMD is a device that consists of a mass which is connected to the structure by means of a spring and a damper. The mass is tuned to vibrate at the different frequency as the structure, which allows it to cancel out the vibrations of the structure. Bracings are added to the structure to provide additional stiffness and strength. G+5, G+15 and G+25 Storeyed steel structure models with the different combinations of bracings and TTMD are considered in this study. Following which the FE Analysis involving the modal, equivalent static and response spectrum analysis are performed and results are obtained in terms of Time period, Base Shear, storey displacement and Storey drift all are discussed.
CHERNOGUBOV — EHLERS — DANLOS SYNDROME AT THE INTERSECTION OF CLINICAL SPECIALTIES
Authors: Mordovtseva V.V. , Gladko V.V.
Published: June 2024

The majority of patients with hereditary connective tissue diseases have cutaneous signs, joint hypermobility and sometimes pathology of other organs and systems. The review of the major symptoms of this syndrome is given in the article.
MEDICAL INFORMATION SYSTEMS IN MODERN CONDITIONS OF MILITARY MEDICAL ORGANIZATIONS' ACTIVITY (Regulatory framework and literature review)
Authors: Sukhorukov A.L , Abushinov V.V , Mayev E.Z
Published: June 2024

The article considers the problematic issues of ensuring communication of military medical organizations in the unified state medical information system. It is shown that a military medical institution is an integral part of the military organization of the state, which is integrated into the nationalheathcare system. Improving the efficiency of military medical institutions is limited by the possibilities of information support for business processes, the speed of information analysis for any period, in any context, and also the ability to establish full management accounting for making reasonable management decisions.
THE PROGNOSTIC ROLE OF THE PROSTATE-SPECIFIC ANTIGEN LEVEL IN HORMONOSENSITIVE PROSTATE CANCER: A CLINICAL CASE
Authors: Gritskevich A.A. , Kochetov A.G. , Baitman T.P. , Savin L.T. , Khromova S.V. , Demidova V.S. , Lebedeva A.N.
Published: June 2024

The article describes a rare clinical case of prostate cancer with a high initial level of prostate-specific antigen — 4000.0 ng/ml. In the diagnostics prosess of drug and subsequent surgical treatment, there was a consistent dynamics of a decrease in the PSA level and an improvement in the clinical picture. Currently, the relapse-free follow-up period is 36 months. The presented clinical observation emphasizes the importance of a personalized approach to the treatment of patients with prostate cancer, and also confirms the need to continue fundamental research in the field of the molecular genetic nature of this disease.
SUMMARISING THE RESULTS OF CREATING FORMULARIES OF ANTIMICROBIAL THERAPY BASED ON MICROBIOLOGICAL MONITORING
Authors: Zubritsky V. F. , Zemlyanoy A. B. , Mikhailov D. Y. , Fominykh E. M. , Matveev D. A. , Seleznev V. V. , Nizovoi A. V. , Batrakova E. V.
Published: June 2024

Background. Currently, the problem of choosing antimicrobial therapy is becoming an increasing challenge. The collecting and analysis of information on the spectrum of microorganisms and their antibiotic resistance allows reasonably to select antibiotic therapy and purposefully develop antibiotic therapy protocols. This approach is widely used in healthcare settings, which makes it relevant to generalize such experience, especially for those institutions where such monitoring is not carried out. Aim. Monitoring and comparison of the features of the local microbial landscape and antibiotic resistance in various hospitals. Materials and methods. The article compares the results of microbiological monitoring in the departments of purulent surgery of the Clinical Hospital of the Medical and Sanitary Department of the Ministry of Internal Affairs of the Russian Federation in Moscow during the period from 2014 to 2018 and N.E. Bauman State Clinical Hospital No29 from 2010 to 2015. Results. In various medical organizations of one city, multidirectional trends in changes in Gr+ and Gr- microorganisms and their resistance were noted. This makes it expedient to develop our own antimicrobial therapy formulary based on local microbiological monitoring in each individual medical institution. Conclusions. International or national recommendations without the local microbial landscape and resistance can only be indicative for a particular medical institution. Protocols for antimicrobial therapy should reflect the peculiarities of the local microbial landscape and the characteristics of antibiotic resistance of the most relevant pathogens for a particular healthcare facility.
أثر القطاع النفطي على بعض القطاعات الاقتصادية في دول مجلس التعاون الخليجي للمدة (2014–2007)
Authors: فارس ناجي ساري
Published: June 2024

المستخلص تعتمد منطقة دول مجلس التعاون الخليجي بصفة رئيسية على النفط، حيث أنها تمتلك أكبر احتياطي نفطي في العالم , وتصنف اقتصاديات دول مجلس التعاون الخليجي ضمن اقتصاديات الدول النامية رغم أنها تدخل في إطار الاقتصاديات النفطية التي تتميز بدرجة عالية من الطاقة التمويلية وارتفاع متوسط دخل الفرد فيها. وعندما كان النفط من أهم مصادر دخل دول المجلس، فإنه من البديهي أن يعتمد أداء الاقتصاد الكلي على ما يتعرض له قطاع النفط من تغيرات. وقد أدركت هذه الدول الخطورة التي تكمن في الاعتماد على سلعة استراتيجية واحدة مثل النفط، لذلك فقد اتجهت إلى محاولة تنويع مصادر الدخل , وبالتالي تنويع الصادرات من أجل التخفيف من تأثير العوامل الخارجية وتقلبات السوق العالمية.ومن المتوقع أن تواصل الطاقة، وبخاصة النفط، هيمنتها على جزء كبير من النشاط الاقتصادي لدول مجلس التعاون الخليجي وعلاقاتها الاقتصادية. ومع ذلك فإن دول المجلس تسعى إلى تنويع الاقتصاد الخليجي باتجاه التصنيع الذي يسهم في تقليص أهمية النفط في الناتج القومي الإجمالي. وقد برزت الصناعة في هذه المجموعة من الدول كقطاع ديناميكي متطور , وقد تشهد نمواً متسارعاً خلال السنوات القادمة. وشهدت منطقة دول مجلس التعاون الخليجي مستويات مرتفعة من الفائض التجاري وفوائض الحساب الجاري (ميزان المدفوعات) , وبما أن التكامل النقدي بين دول مجلس التعاون لدول الخليج العربية يعدّ محورًا رئيسًا لتقليل أثر التقلبات الاقتصادية الخارجية على اقتصاداتها المحلية، والحصول على شروط أفضل في نطاق مبادلاتها الدولية، وتحقيق تنمية اقتصادية مشتركة .AbstractGulf Cooperation Council (GCC) region is mainly dependent on oil, Where it has the largest oil reserves in the world are classified as    Economies of the Gulf Cooperation Council (GCC) in the economies of Developing countries even though they are part of the oil economies, Which is characterized by a high degree of financing energy and high per Capita income. When the oil was of the most important sources of Income of the GCC countries, it is obvious that the macroeconomic Performance depends on the suffering of the oil sector of the changes. These countries have realized the danger that lies in the dependence on A single cough such as oil strategy, So it has tended to try to diversify Sources of income and thus export diversification in order to mitigate the Impact of external factors and the vagaries of the global Market. It is Expected to continue to energy, especially oil, hegemony over a large ofThe economic activity of the GCC economic relations.  However, the GCC Countries seek to diversify the Gulf economy towards Manufacturing, Which contributes to reducing the importance of oil in  The GNP . The Industry has emerged in this group of countries as a Sector dynamically Evolving and is expected to witness a rapid growth in The coming years. Gulf Cooperation Council (GCC) region has seen high levels of trade Surplus and current account surpluses (balance of Payments), Since the Monetary integration among the GCC countries of The Gulf is a prime hub To reduce the impact of external economic Fluctuations on the local Economies, and get the best in terms of the Scope of international trade-Offs , and achieve  economic  development.
استقرار اسعار النفط.. ماذا يعني للمستقبل
Authors: عبد حسين علي
Published: June 2024

القى انتشار فيروس كورونا المستجد Covid-19 بضلاله على الاقتصاد العالمي، اذ تراجعت معدلات النمو الاقتصادي، وانخفض حجم التجارة العالمية، وتزايدت معدلات البطالة وشهدت أسواق المال العالمية اضطرابات حادة وحققت خسائر كبيرة جداً، تزامن ذلك مع ركود يعيشه الاقتصاد العالمي وحرب تجارية بين الولايات المتحدة الامريكية والصين. امتدت اثار تفشي الفيروس الى اغلب دول العالم وانكمش الطلب العالمي, وقد هزت المخاوف من تفشي الفيروس على نطاق واسع الاقتصاد العالمي، فانخفضت توقعات النمو الاقتصادي الى نحو النصف وتراجعت التجارة واضطربت الأسواق المالية وتراجعت اغلب المؤشرات الرئيسة لها، وأعلنت منظمة العمل الدولية عن احتمال ان يكون هناك 25 مليون عاطل عن العمل، وأوضحت منظمة السياحة العالمية الى ان القطاع السياحي يخسر يومياً مليون فرصة عمل. وقد سارعت المنظمات المالية العالمية والدول المتقدمة لإطلاق مبادرات وبرامج ضخمة (مالية ونقدية) لتحفيز ودعم اقتصاداتها عبر تخفيض أسعار الفائدة الى مستويات قريبة من الصفر وتقديم الدعم المالي والقروض واتباع سياسات تيسريه لدعم النشاط الاقتصادي.
تفعيل استراتيجية التنمية المحلية في اطار الحوكمة (رؤية استراتيجية)
Authors: محيميد كفاح عباس
Published: June 2024

يهدف البحث الحالي إلقاء الضوء على بعض المفاهيم التي تعرض دور الحوكمة في التوجهات التنموية للإدارة المحلية ومعطيات الإصلاح المطلوبة . إذ أن عملية الإصلاح بأبعادها المختلفة تستند على قاعدة الرشادة في أسلوب الإدارة، وبالتالي البحث عن الآليات الكفيلة لحشد جهود المجتمع المحلي لرفع مستوى أداء وقدرات الإدارة المحلية، وان الغرض من البحث هو تسليط الضوء على دور الحوكمة في منظمات القطاع العام، وعدت استراتيجية التنمية المحلية ومنظمات الحوكمة بأبعادهن الرئيسية والفرعية هي متغيرات البحث وفقا للرؤيا الاستراتيجية وانسجاما مع أدبيات التوجه الإصلاحي الذي بات مطلوبا في البيئة المحلية للعراق، اذ ان البناء برؤيا متجددة لدولة عصرية يتطلب الاتساق مع سمات التطورات العالمية والمحلية وامتلاك قدرات متطورة للمساهمة في البناء وتحقيق التنمية.
واختيرت الادارة المحلية لمحافظة صلاح الدين وتوابعها الادارية ميدانا لتشخيص تلك المنطلقات، ووظفت تلك الجزئيات في سياق منطقي وعملي ليكون نموذجا ونقطة انطلاقه نحو استطلاع أراء (المجالس والادارات المحلية)، وتم استخدام استمارة الاستبانة كأداة رئيسية في جمع البيانات المتعلقة بالجانب الميداني من البحث، وبلغ حجم العينة (30) فردا . وتم تحليل البيانات لإجابات عينة البحث، واختبار الفرضيات بالاستعانة بعدد من الوسائل والأدوات الإحصائية وباستخدام البرنامج الاحصائي(SPSS)، وتوصل البحث إلى مجموعة من التوجهات المطلوبة للإصلاح وانه من اهم الاستنتاجات التي توصل اليها البحث انه لم تشهد البيئة العراقية أي من البرامج التنموية الطموحة، وان وجد البعض منها في حدود محافظات مستقرة امنيا، فضلا عن تقديم مجموعة من التوصيات التي تعزز من أمكانية تفعيل استراتيجية التنمية المحلية في اطار الحوكمة وكانت اهم توصية ولكي تتمكن الحكامة المحلية من أن تكون في مستوى تطلعات المواطنين والسلطات العمومية وفي مستوى التحديات التي تنتظر المجتمع فإنه يتعين القيام بإعادة تأهيل حقيقي سواء من طرف الدولة أو من طرف الجماعات المحلية نفسها .
استخدام نموذج مضاعف السعر والارباح المعدل دوريا لتقييم الاسواق المالية: دراسة تحليلية في سوق العراق للأوراق المالية للمدة (2022 – 2013)
Authors: رحيم بنين أحمد رحيم , العــلــي علي حميد هندي
Published: June 2024

تبحث الدراسة الحالية في الدور الحقيقي الذي يمكن أن يلعبهُ نموذج مضاعف السعر الى الأرباح المعدل دوريا في تحقيق التقييم الموضوعي للأسواق المالية، إذ يعد هذا النموذج من المواضيع المهمة لدى المستثمرين والشركات على حدٍ سواء كونه يتعلق بنسبة مالية مهمة لكليهما وهي نسبة السعر الى الربحية، وبما أن هذه النسبة قد واجهت العديد من الانتقادات بسبب عدم مراعاتها حالات التضخم لذا جاءت الدراسة الحالية للكشف عما يمكن ان يقدمه نموذج CAPE في تقييم الأسواق المالية فضلا عن كشف المزايا الأخرى للنموذج.
      إعتمدت الدراسة في قياس متغيراتها على عدد من المؤشرات المالية والمعادلات الإحصائية، لعل أهمها: (مضاعف السعر، نسبة التضخم) فيما يتعلق بالمتغير المستقل، أما فيما يتعلق بالأسواق المالية، فقد تم الاعتماد على ثلاثة مؤشرات مالية هي: (المؤشر الموزون بالسعر، المؤشر الموزون بالقيمة، المؤشر متساوي الأوزان)، وتم تطبيق الدراسة على مجتمع يتكون من الشركات المدرجة في سوق العراق للأوراق المالية، بينما تضمنت العينة (30) شركة موزعة على قطاعات السوق كافة والتي تمثل أفضل الشركات من حيث رأس المال، وبما يتناسب مع مؤشر Dow Jones الصناعي والذي يمثل مؤشر السوق العام، وقد امتدت مدة الدراسة للسنوات (2022 – 2013).
   توصلت الدراسة الى عدد من الاستنتاجات المهمة، ولعل من أهمها هو وجود تفاوت كبير بأسعار الاسهم المتداولة في السوق المالي العراقي، اذ أنها تتصف بالمبالغة الكبيرة في قــيّـميها كونها مقومة بأعلى من قيمتها الحقيقية، كما اشارت النتائج الى عدم كفاءة سوق العراق للأوراق المالية بسبب تفاوت الأسعار غير المبرر الامر الذي ينتج عنهُ أخطاء في تسعير الأسهم للشركات المدرجة في السوق، وقد أوصت الدراسة بضرورة تقليل الأخطاء والمشاكل الناتجة عن تسعير الأسهم المتداولة لينعكس هذا الامر ايجاباً على تحقيق الكفاءة للسوق المالي والتأكيد على الشركات المدرجة في السوق بضرورة تعزيز الإفصاح عن المعلومات المالية والتشغيلية بشكل دوري ودقيق.
دور الائتمان الأخضر في تحسين الأداء المالي دراسة تحليلية للمصارف التجارية للمدة(2010-2022)
Authors: تكليف نورس عطا , فليفل علي عبد الامير
Published: June 2024

تهدف الدّراسة الحالية إِلى مُساعدة الجهاز المصرفي العراقي على الوقوف عِند هذه المُشكلة ألا وهيّ البحث حول معرفة واقع الإئتمان الأخضر ودوره في تحسين الأداء المالي للمصارف التجارية العراقية، مِمّا أستدعى الوقوف عِند هذه المُشكلة وتقديم أفضل المُقترحات ألتي مِنْ شأنها المُساهمة في تعزيز دور الائتمان الأخضر، وقد تضمْن مُجتمع الدّراسة الجهاز المصرفي العراقي وشملت الحُدود الزمانّية للدّراسة المدّة الممتدّة (2010- 2022)، وقد تمّ الإِعتماد على بيانات القطاع المصرفي العراقي الخاصة بموضوع الدّراسة وألتي تمّ توظيفها في جانب التحليل المالي والقياسي لِقياس مُتغيّرات الدّراسة، إِذ جرى إِختبار الفرضيّات الرئيسية المُتعلقة بعِلاقات الإِرتباط والتأثير بيّن متغيّرات الدّراسة بالإِعتماد على البرنامج الإحصائي SPSS))،وقد توصّلت الدّراسة إِلى مجموعة مِنْ الإِستنتاجات أهمّها أن المصارف التجارية لا تميز بين الإئتمان الأخضر والإئتمان للمشاريع المضرة للبيئة فهي تقدم الإئتمان بكافة أنواعه،إضافة إلى ضعف دور البنك المركزي وخاصة في السنوات الأولى من مدة الدراسة في سن القوانين الخاصة بحماية البيئة فضلا عن ضعف التحفيزات في هذا المجال، أمّا أهم التّوصيات فكانت بضرورة وضع المصارف إجراءات وقيود صارمة تحد من التمويل للمشاريع المضرة بالبيئة من خلال رفع معدلات الفائدة على تمويل تلك المشاريع، والتوجه نحو التمويل بالائتمان الأخضر لما لهُ الأثر على الأداء المالي للمصارف من جهة وعم التنمية المستدامة من جهة أخرى، وضرورة اتخاذ البنك المركزي تدابير ائتمانية لتحفيز الاستثمارات الخضراء والصديقة للبيئة، مثل أقساط القروض الخضراء والقروض الميسرة للقطاعات ذات الأولوية.
الهجرة واداء التنمية المستدامة في الدول المصدرة والمستقبلة للمهاجرين
Authors: الشمرتي زهراء رعد راضي , الشيخ راضي مازن عيسى
Published: June 2024

استعرض البحث موضوعا يعد من أهم مواضيع الساحة العالمية في الوقت الحاضر واكثرها تشعبا وحساسية، كونه يربط بين الهجرة واهداف التنمية المستدامة، من خلال ما تضمنت لأول مره اجندة التنمية المستدامة لعام 2030 من اهداف مباشره حول الهجرة وحقوق المهاجرين، إِذ تم تسليط الضوء على اتجاهات الهجرة وأنماطها في العالم، والعراق تحديدا  يتم استكشاف حركات الهجرة وملامح المهاجرين منه واليه، العمل على اهداف التنمية المستدامة.ومؤشراتها في كل من دول المنشأ ومقصد ومساراته.
لهذا تم اعتبار الهجرة مساهمة هامة في التنمية المستدامة. وبالتالي، تعد المنظمة الدولية للهجرة جهة فاعلة مهمة في تنفيذ أهداف التنمية المستدامة المتعلقة بالهجرة.
الارتدادات الاقتصادية للقيد المركب (الطاقة – الغذاء) وأثره على النمو الاقتصادي في العراق للمدة(2004-2022)
Authors: الساعدي زاهد قاسم , الفيصل إيهاب عباس
Published: June 2024

على الرغم من امتلاك العراق لمقومات اقتصادية كبيرة في مجالات الطاقة والغذاء، الا ان هناك تحديات عديدة تتمثل بالقيد المركب وارتداداته على الاقتصاد خاصة في ظل غياب الارادة الحقيقية لتطوير المجالات المختلفة في الطاقة والغذاء وبما يضمن تأمين الأمنين الطاقوي والغذائي، ومن ثم الأضرار الاقتصادية الفورية التي أحدثها الاعتماد الكبير على تصدير النفط بصورته الخام وبالتالي النقص الكبير في إمدادات الطاقة الكهربائية والمنتجات النفطية واستيرادها والغاز وفقدانه، فضلاً عن نقص الغذاء وعدم تأمينه مما الحق الضرر بالاقتصاد، ان اعتماد العراق المطلق على انتاج النفط الخام وتصديره وضياع القيمة المضافة الناتجة عن تكريره واعتماده المطلق على التجارة الخارجية في استيراد معظم السلع وأغلب الخدمات اللازمة لسد الاحتياجات الاستهلاكية وبالأخص الاستيراد المتزايد للسلع الزراعية وخصوصاً الغذائية، كل ذلك أسهم في فقدان أمنه الاقتصادي، فالتغييرات الاقتصادية لم تؤدَّ بعد الى ايجاد بناء إنتاجي قادر على دعم الاقتصاد والنهوض به.
صناعة الغاز الطبيعي في العراق وافاقها المستقبلية
Authors: الياسري احمد جاسم جبار , جـبر يحيى نافــــع
Published: June 2024

العراق احد البلدان التي تمتلك احتياطيا من الغاز الطبيعي جله من الغاز المصاحب، اذ يبلغ المصاحب منه  قرابة 70% ، وكان وما يزال غير قادر على استخدام هذا الوقود الواعد بصورة اقتصادية مثلى، اذ يحرق الكثير منه الان، الا ان الاهتمام الذي اولته وزارة النفط في الحد من هذا التبذير بدأت تعطي ثمارها، الا انها في مراحلها الاولية ومن المتوقع ان يدخل العراق سوق الغاز الطبيعي العالمي في المدى المنظور، وهذا التطور يحد من الانبعاثات الضارة جراء الحرق المستمر للغاز المصاحب فضلا عن تعزيز الطاقة الكهربائية من خلال تأمين وقود مستمر لها ناهيك عن الايرادات التي يحققها للاقتصاد من خلال توفير العملات الصعبة لميزانية الدولة وتوفير الوقود اللازم للقطاع الصناعي ولا سيما البتروكيمياويات والاسمدة والحديد والصلب وتوفير فرص العمل لقوى العمل .
Baclofen and Consciousness Disorders in Chronic Hemodialysis: A Case Report
Authors: M Tangara , O Traore , A Kouma , N Haidara , F BIlumbu , S Sy , A Toure , H Kongoulba , H Yattara , S Diakite , MD Sidibe , N Camara , OL Bagayoko , S Djimdé , M Coulibaly
Published: June 2024

Baclofen is a chlorophenyl derivative of gamma-aminobutyric acid, which is ubiquitous in the central nervous system and which is the main inhibitory neurotransmitter of the Central Nervous System. Overdose of Baclofen treatment can be life-threatening for the patient. We report the case of a 58-year-old patient with a history of hypertension. He was treated with COVERAM 10/10, Physiotens 0.4. He has been on chronic hemodialysis for three years for nephroangioslerosis. The patient was admitted to the hospital by his neurologist for disturbances in alertness after administration of Baclofen 120 mg/day orally for neuromuscular pain. Clinically he had disturbances of consciousness (Glasgow score of 10) without signs of neurological focalization. Hemodynamic constants were normal. The biological assessment revealed chronic end-stage renal failure with Cockcroft clearance at 2 ml/min. The electrocardiogram was without abnormality. Chest x-ray, brain CT scan and lumbar puncture were normal. The electroencephalogram showed diffuse slowing. A probable drug poisoning was mentioned. A 4-hour hemodialysis session was undertaken with a favorable clinical outcome. The objective of our work was to provide our experience on a case of Baclofen poisoning occurring in a chronic hemodialysis patient in the nephrology department of Point “G” University Hospital.
Pleural Desmoid Tumour: A Case Report
Authors: Nzingoula C.M. , Odoulou B. , Diakite M. , Kyabambu C.M. , Bouktib Y. , Hajjami A. El , Boutakioute B. , Idrissi M. Ouali , Ganouni N. Cherif Idrissi El
Published: June 2024

Desmoid tumours or fibromatoses are rare, benign fibroblast tumours of the soft tissues, characterised by invasive infiltration and a very high rate of local recurrence, but without metastatic potential. Pleural localisation is extremely rare. The diagnosis of certainty is histological. Imaging is not very specific. We describe the case of a patient with a pleural desmoid tumour.