bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of crystallographic anisotropy on the electrical conductivity of apatite at high temperatures and high pressures
Authors: Hu Ziming , Dai Lidong , Hu Haiying , Sun Wenqing , Wang Mengqi , Jing Chenxin , Yin Chuanyu , Luo Song , Lai Jinhua
Published: August 2023

The electrical conductivity of apatite single crystals along three main crystalline directions was measured in situ using a YJ-3000t multi-anvil apparatus and a combined system consisting of the impedance/gain-phase analyzer (Solartron 1260) and dielectric interface (Solartron 1296) at 973–1373 K and 1.0–3.0 GPa. The obtained results indicate that the relationship between the electrical conductivity and temperature conforms to the Arrhenius relation. At 2.0 GPa, the electrical conductivity of apatite with relatively high activation enthalpies of 1.92–2.24 eV shows a significant anisotropy with an extremely high anisotropic degree (τ = ~8–16) value. For a given [001] crystallographic orientation, the electrical conductivity of apatite slightly decreases with increasing pressure, and its corresponding activation energy and activation volume of charge carriers are 2.05 ± 0.06 eV and 9.31 ± 0.98 cm3/mol, respectively. All of these observed anomalously high activation enthalpy and positive activation volume values suggest that the main conduction mechanism is related to the monovalent fluorine anion at high temperature and high pressure. Furthermore, three representative petrological average schemes, including the parallel, Hashin-Shtrikman upper bound, and average models were selected to establish the functional relation for the electrical conductivity of the phlogopite-apatite-peridotite rock system along with the volume percentages of apatite ranging from 1 to 10% at 973–1373 K and 2.0 GPa. For a typical Hashin-Shtrikman upper bound model, the electrical conductivity-depth profile for peridotite containing the 10% volume percentage of apatite was successfully constructed in conjunction with our acquired anisotropic electrical conductivity results and available temperature gradient data (11.6 and 27.6 K/km) at depths of 20–90 km. Although the presence of apatite in peridotite cannot explain the high-conductivity anomalies in western Junggar of Xinjiang autonomous region, it may provide a reasonable constraint on those of representative apatite-rich areas.
Znucalite, the only known zinc uranyl carbonate: Its crystal structure and environmental implications
Authors: Steciuk Gwladys , Majzlan Juraj , Rohlíček Jan , Škoda Radek , Sejkora Jiří , Plášil Jakub
Published: August 2023

Znucalite is a zinc uranyl-carbonate mineral that was until recently only partially characterized with a formula originally given as Zn12Ca(UO2)(CO3)3(OH)22·4H2O, with an unknown crystal structure and ambiguous symmetry determinations. We have reinvestigated this mineral using three-dimensional electron diffraction (3D ED) and powder X-ray diffraction and revealed for the first time its structural details. Znucalite is unambiguously monoclinic, P21/m, with a = 10.722(2) Å, b = 6.259(1) Å, c = 25.355(1) Å, β = 101.13(1)°, and V = 1669.54(9) Å3. The structure refinement of the 3D ED data using the dynamical approach (Robs = 0.1594 for 3579 observed reflections and 244 parameters) provided the following structure model. Znucalite possesses a layered structure, with a [Zn10(OH)14(CO3)2] double sheet (with Zn2+ both in octahedra and tetrahedra), which is connected to a thick interlayer that hosts U 6+, Ca2+, and H2O molecules. The linkage between structural units and the interlayer occurs via the vertices of ZnO4 tetrahedra protruding from the sheet. In the interlayer, differences in ordering between U and Ca take place and likely cause the difficulties encountered during the attempts to solve the structure. The refined structural formula of znucalite, Zn10Ca0.828[UO2]0.828[CO3]4(OH)15.312(H2O)5.484, corresponds well to the composition obtained from the electron-microprobe analyses, (Zn9.84Al0.16)Σ10.00 Ca0.83(UO2)0.80[(CO3)3.96(SO4)0.04]Σ4.00(OH)15.42(H2O)5.48. Raman spectroscopy evidenced the presence of several non-equivalent CO3 groups, as well as OH and H2O. The U-O bond lengths obtained from the stretching frequencies of UO22+ vibrations are in line with the structural model. A discussion on the environmental importance of znucalite is appended, based on geochemical calculations with an estimate of the solubility product for this mineral.
Percepciones alrededor de la educación en época de pandemia por parte de docentes de formación escolar en Colombia, Argentina y Chile
Authors: Pérez John Jairo , Nakayama Lilia , Fredes Karen
Published: August 2023

La realidad del coronavirus ha supuesto múltiples transformaciones en diversos sectores sociales, de los cuales el campo de la educación no es ajeno. En este contexto, los cambios han transitado por nuevos escenarios formativos que hacen uso de la tecnología, la formación a distancia y la virtualidad, hecho que para muchas instituciones educativas y docentes se constituyen en experiencias novedosas. Este escenario supuso para los docentes un desafío particularmente difícil al momento de gestar prácticas educativas en tiempo de pandemia. A partir de lo descrito, la presente investigación se propone analizar las percepciones alrededor de la experiencia de educar en época de pandemia en una muestra de docentes colombianos, argentinos y chilenos. Para ello se acude a dos tipos de investigación enmarcados en un paradigma cualitativo, el primero indaga las representaciones sociales con la técnica de redes semánticas naturales y el segundo recupera narrativas que son analizadas con la técnica de análisis de contenido. Con los datos recogidos se realiza un análisis estableciendo predominancias, similitudes y diferencias entre los países, en los cuales se evidencia algunas tendencias y recurrencias en torno a las dificultades de educar en tiempo de pandemia, tales como la conectividad, uso de tecnologías, tiempo, emociones, entre otros. Al mismo tiempo se rescatan algunos aspectos que sugieren una capitalización de la situación, a partir de la superación de la adversidad con experiencias educativas marcadas por lo novedoso, la valoración de las relaciones entre las personas, el rol del docente, la familia, los recursos y estrategias pedagógicas, entre otros.
Vínculos, autonomía y salud mental en adultos jóvenes del proceso de reintegración en Colombia
Authors: Zapata García José , Laverde Gallego Diana Janneth , Manrique López Juan Guillermo , Aponte Canencio Diego Mauricio , Ruiz Parra Shennya , Durán Alicia S.
Published: August 2023

Este artículo busca explorar la construcción de los vínculos, su relación con el desarrollo de la autonomía y las problemáticas de salud mental de adultos jóvenes excombatientes de grupos armados que hacen parte del proceso de reintegración en Colombia. Se analizaron 3977 registros de la Encuesta Multimodal Psicosocial (EMP) correspondientes a adultos jóvenes entre los 18 y 24 años, que fueron aplicadas en desarrollo del proceso de reincorporación. Se aplicaron dos métodos de análisis estadísticos complementarios: el método de Componentes Principales (ACP) y un método Jerárquico aglomerativo. En el análisis de los procesos vinculares se encontró que en un grupo alrededor de un 80 % de los casos registra haber experimentado rupturas vinculares importantes a causa de la violencia, el abandono temprano y/o vivir en contextos de conflicto y violencia. En cuanto al análisis de los procesos de autonomía, se encontró que un grupo correspondiente al 70 % reporta no contar con las capacidades para garantizar su autonomía y calidad de vida, pasando por condiciones de precarización laboral con riesgo a incurrir en redes de delincuencia. Y un 39 % reporta coincidir alta disposición de riesgo en sus procesos vinculares y de autonomía.
Consideraciones filosóficas sobre la ontología de la consciencia y los conceptos mentales: un siglo de debates
Authors: Gómez-Tabares Anyerson Stiths
Published: August 2023

La discusión en filosofía de la mente del último siglo giró en torno a los dualismos y monismos ontológicos para explicar la consciencia y los conceptos mentales. Uno de los rasgos distintivos de la discusión fue la pregunta por la existencia de una brecha explicativa entre las categorías mentales y físicas, y el reto de explicar la relación causal entre estas. De ahí que el objetivo de este trabajo sea analizar los problemas que no permitieron el avance en la reflexión filosófica sobre la ontología de la consciencia y los conceptos mentales. Para ello, primero, se introduce el problema difícil de la consciencia y las diversas acepciones sobre lo que significa ser consciente; segundo, se analiza críticamente algunas de las tendencias ontológicas dualistas y monistas más emblemáticas de la filosofía; tercero, se presentan varias de las inconsistencias de las teorías ontológicas tradicionales respecto a la comprensión de la consciencia y el lenguaje psicológico, y cuarto, se brindan argumentos a favor de la idea de que muchos de los problemas filosóficos sobre la consciencia y la relación entre la mente y el cuerpo son el resultado de un mal entendimiento de la naturaleza de los conceptos mentales. El artículo concluye que la negación de la experiencia consciente, el lenguaje mental y los dilemas categoriales de la tradición dualista cartesiana deben quedar en el pasado.
Philip k. Dick y el gnosticismo: catálogo de mitemas compartidos
Authors: Martínez Villarroya Javier
Published: August 2023

A partir de las propuestas metodológicas de los Estudios del Imaginario, este trabajo busca mostrar que algunas de las principales tramas ideadas por Philip K. Dick tienen un sustrato gnóstico. Para ello, en primer lugar, mencionamos algunos datos biográficos que muestran el interés de Dick por el gnosticismo; en segundo lugar, identificamos mitemas idénticos entre ambos corpus (“este mundo es un engaño”; “este mundo es una prisión de hierro”; “el iniciado tiene un doble”; etc.). Con ello, esta investigación contribuye al debate científico en torno a la recepción y reutilización de antiguos mitos en la literatura de ciencia ficción.
Stochastic Sensing of Organotin Compounds with Alpha-Hemolysin Nanopore
Authors: Silva Artur , Silva Júnior Janilson , Machado Dijanah , Pontes Frederico , Pol-Fachin Laércio , Aguiara Juliana , Rodrigues Claudio
Published: August 2023

Organotin compounds (OTCs) are pollutants that affect the reproduction of some marine organisms and can cause autoimmune diseases in humans. Most of the techniques used for detection and monitoring of OTCs in the environment have limitations due to several stages of sample pre-processing. Here, we demonstrated the use of the α-hemolysin (αHL) nanopore as an alternative platform for the detection of the cyhexatin and diphenyltin dichloride (DPhT) in aqueous systems. The detection process is based on the analysis of the residence times of each OTCs within the unitary nanopore, as well as, on the amplitudes of the blockages in the ionic current flowing through it. Cyhexatin and DPhT induced two and three patterns in the amplitude of the blockages in the ionic current, respectively. Residence time value of the cyhexatin inside the nanopore was higher than the value presented by the DPhT. Molecular docking was used to evaluate the interactions between OTCs and nanopore constriction, mainly identifying cation-π and hydrogen interactions. Classical atomistic molecular dynamic simulations confirm moderate aggregative behavior of these OTCs in solution in cationic form, especially for cyhexatin species. The nanopore detects OTCs at nanomolar level and it is possible to use this nanopore to monitor OTCs in aqueous systems.
Ofatumumab and Early Immunological Cells Subset Characterization in
Naïve Relapsing Multiple Sclerosis Patients: A Real-World Study
Authors: D’Amico Emanuele , Zanghì Aurora , Fantozzi Roberta , Centonze Diego , Avolio Carlo
Published: August 2023

Background:

Ofatumumab (OFA) is a fully human anti-CD20 monoclonal antibody administered
with a 20 mg subcutaneous monthly dosing regimen.

Methods:

Inclusion criteria were patients: 1) aged 18-55; 2) with a confirmed diagnosis of relapsing
Multiple Sclerosis (RMS), per the revised 2010 McDonald criteria; 2) who started OFA according to
Italian Medicines Agency prescription rules and within 12 months from the RMS diagnosis; 3) naïve
to any disease-modifying therapy. The primary outcome was to offer an overview of cellular subsets
of RMS naïve patients (time 0) and then after 4 weeks (time 1) and 12 weeks (time 2) on therapy with
OFA in a real-world setting.

Results:

Fifteen patients were enrolled. CD3+ T cell frequencies were higher at time 1 (%80.4, SD
7.7) and time 2 (%82.6, SD 5.8) when compared to time 0 (%72.4, SD 9.8), p = .013. B naïve cells
were barely detectable in the OFA group at time 1 (%0.4, SD 0.5) and 2 (%1.4, SD 2.9) when compared
to time 0 (%11.5, SD 3.8), p < .001.

Conclusion:

The progressive and increasing use of anti-CD20 drugs imposes the need for larger, prospective,
real-world, long-term studies to characterize further immunophenotypes of patients with
RMS treated with OFA.
Identification of Methamphetamine and Amphetamine in Drug Abuse
Urine Sample using Multi-drug Rapid Test and Gas Chromatography-
Mass Spectrometry (GC-MS) at the Centre of Drug Testing Laboratory,
National Narcotics Board Republic of Indonesia
Authors: Sandy Kurnia , Rahmania Tesia Aisyah , Arfiyani Eri
Published: August 2023

Introduction:

Drug abuse is a real threat that threatens the Indonesian nation in the form of
non-military threats. The second most abused illicit substance in the world is methamphetamine
(MA). Most of the methamphetamine users in the world live in East and Southeast Asia. Methamphetamine
is a powerful stimulant of the central nervous system (CNS) that can make someone feel an increase
in sympathomimetic.

Methods:

First, the preliminary test was conducted using a BioCare multi-drug rapid test and a specific
methamphetamine rapid test that works based on the Lateral Flow Assay (LFA) principle. Second, the
sample preparation used Liquid-Liquid Extraction (LLE). Third, GC-MS confirmed the test using GCMS
Shimadzu-QP2020NX-GC-2030 (HP-5MS column, Length 30 m, diameter 0.25 m, film 0.25).

Result and Discussion:

The Preliminary test shows that the urine is positive and contains methamphetamine
and amphetamine. Based on the sample chromatogram, There are 2 peaks, which are methamphetamine
and amphetamine compounds it can be seen by the retention time is 5.560 minutes
(methamphetamine) a similarity index of 98% to methamphetamine compounds, and 4.885 minutes
(amphetamine) with a similarity index of 96% to amphetamine compounds.

Conclusion:

The urine samples with code 210DGB from methamphetamine users were detected due
to the presence of methamphetamine and amphetamine, which is the metabolite of methamphetamine.
Isolation and Biochemical Characterization of Ananassains, Cysteine Peptidases
from the Fruits of Ananas ananassoides
Authors: Okayama Adriana , Cabral Hamilton , Gustavo Orlando Bonilla-Rodriguez
Published: August 2023

Aims:

This work performed a preliminary characterization of two new peptidases from
Ananas ananassoides.

Background:

Proteolytic enzymes, also known as peptidases, are found in all living things and play
critical physiological roles in metabolism and cellular regulation. They account for roughly 60% of the
enzymes used in industry and have high proteolytic activity, such as papain from Carica papaya latex
and stem and fruit bromelains from the edible pineapple Ananas comosus.

Objective:

The wild pineapple Ananas ananassoides contains proteolytic enzymes, which motivated
this study due to the potential applications of this type of enzyme.

Methods:

The fruit and stem of A. ananassoides were blended, clarified, and purified using chromatography
(SP-Sepharose and Sephadex G-50). The molecular mass was determined using mass spectrometry
(M.S.), and the N-terminal sequences were obtained and compared to other Bromeliaceae
proteases. Fluorogenic substrates were used to determine the kinetic parameters.

Results:

As determined by M.S., the fruit and stem contain cysteine-peptidases with Mr of 27,329.6
and 23,912.5 Da, respectively, values that are very similar to those found in edible pineapple bromelains.
Despite Mr and carbohydrate composition differences, both proteases have similar optimum pH
values. They have similar temperature effects, though the stem protease is more thermally stable. Both
proteases have a stronger preference for hydrophobic, polar, and basic residues. Both proteases hydrolyzed
substrates containing polar and basic residues.

Conclusion:

A comparison of the N-terminal sequences (AVPQIIDW for fruit ananassains and AVPEIIDW
for stem ananassains) reveals a high degree of homology when compared to other Bromeliaceae
proteases such as papain.
Natural Flavonoids as an Intervention for Hepatic Encephalopathy: Preclinical
Evidence-based Review
Authors: Singh Niraj Kumar , Solanki Ashutosh
Published: August 2023

Hepatic encephalopathy (HE) is a serious neuropsychiatric disorder caused in patients
with both; acute and chronic liver diseases, which consists of various complications ranging from
cognitive impairment, disorientation, confusion, and coma. The available therapies mainly focus on
decreasing ammonia levels either through increasing its elimination or decreasing its production,
some medications may subside the duration and limit the consequences of HE, but there is no complete
available treatment for HE-like manifestation. Thus, there is a need to explore new pharmacotherapy
for the treatment and management of HE. Flavonoids are polyphenolic compounds easily
found in vegetables, fruits, flowers, beverages, and plants based foods. In modern research, flavonoids
have gained attention due to their broad pharmacological properties, like anti-oxidant, antiviral,
anti-inflammatory, cardioprotective, cytoprotective, and neuroprotective activity. Several preclinical
studies suggest that various flavonoids have a potential therapeutic role in a variety of metabolic-
related neurological disorders, including HE. This review focuses on all pre-clinical reports
that highlight the neuroprotective potential of natural flavonoids for the management of HE. Based
on numerous pre-clinical studies and taking into account the therapeutic effects of natural flavonoids,
the present study illustrates the cellular and molecular mechanisms responsible for the potential
role of natural flavonoids as pharmacotherapy for the management and treatment of HE.
Do Personality Traits Predict Mental Well-being in the Context of
Erroneous Subjective Estimation of Smartphone Screen Time?:
Findings from a Cross-sectional Observational Study Among
College Students
Authors: Balhara Yatan Pal Singh , Singh Swarndeep , Ganesh Ragul , Kattula Dheeraj , Abhijita Bandita , Gupta Amulya , Gupta Abhinav
Published: August 2023

Background:

The current article reports on the findings from a cross-sectional survey
conducted among college students on a subjectively reported and objectively measured
smartphone screen time (ST) and its relation to mental well-being.

Methods:

We explored the magnitude of discrepancy between subjectively reported and objectively
measured smartphone ST. Moreover, we assessed the interaction of mental well-being
with personality traits among subjects with a discrepancy between the subjectively reported
and objectively measured smartphone ST. The mental health of study participants was assessed
using the WHO well-being index. Personality was assessed using the Big Five Inventory (BFI)-
10. A total of 202 students shared screenshots of the phone ST function and were included in
the analysis.

Results:

A total of 145 (71.8%) participants underestimated their daily smartphone ST, whereas
56 (27.7%) of them overestimated ST. In the regression analysis, the predicted odds of poor
mental well-being were 1.43 times greater for subjects with higher neuroticism scores in the
overall sample. Moreover, the predicted odds of poor mental well-being were 1.593 times
greater for subjects with higher neuroticism scores among the study subjects who underestimated
their ST.

Conclusions:

The findings of the current study suggested that the magnitude of discrepancy
between the subjectively estimated and objectively estimated ST varies across college students,
with the discrepancy being significantly higher among those who overestimated their ST. The
predicted odds of poor mental well-being were about one and a half times greater for subjects
with higher neuroticism scores among college students who underestimated their ST.
Cмешение струй газов различной молекулярной массы с высокоскоростным потоком воздуха при изменении их динамического напора
Authors: Акинин А.С. , Коротаева Т.А. , Старов А.В.
Published: August 2023

The results of a computational and experimental study of the distributed transverse injection of hydrogen and methane jets into a high-speed flow are presented. The effect of jets on the flow structure in a rectangular channel of a variable cross section is determined when the dynamic head coefficient changes in the range 1.27-6. It is shown that the mixing efficiency increases with an increase in the dynamic head and, to a lesser extent, with an increase in the molecular weight of the injected gas.
Осаждение прозрачных покрытий Al-=SUB=-2-=/SUB=-O-=SUB=-3-=/SUB=- с экстремальными свойствами смачивания методом наносекундной лазерной абляции алюминия в фоновом кислороде
Authors: Родионов А.А. , Мельник А.В. , Суляева В.С. , Шухов Ю.Г. , Васильев М.М. , Старинский С.В.
Published: August 2023

Transparent aluminum oxide nanostructures with extreme wetting properties were synthesized by nanosecond laser deposition in background oxygen. The transparency and morphology of the samples have been analyzed. Non-monotonic behavior of the transmittance coefficient was found when varying the background oxygen pressure in the range of 20-140 Pa due to differences in the kinetics of ablation product dispersion. The evolution of the contact wetting angle from ~ 5 to ~ 120◦ when the coatings are stored in air under normal conditions was investigated.
Effect of Benign Biopsy Findings on an Artificial Intelligence–Based Cancer Detector in Screening Mammography: Retrospective Case-Control Study
Authors: Zouzos Athanasios , Milovanovic Aleksandra , Dembrower Karin , Strand Fredrik
Published: August 2023

Background

Artificial intelligence (AI)–based cancer detectors (CAD) for mammography are starting to be used for breast cancer screening in radiology departments. It is important to understand how AI CAD systems react to benign lesions, especially those that have been subjected to biopsy.

Objective

Our goal was to corroborate the hypothesis that women with previous benign biopsy and cytology assessments would subsequently present increased AI CAD abnormality scores even though they remained healthy.

Methods

This is a retrospective study applying a commercial AI CAD system (Insight MMG, version 1.1.4.3; Lunit Inc) to a cancer-enriched mammography screening data set of 10,889 women (median age 56, range 40-74 years). The AI CAD generated a continuous prediction score for tumor suspicion between 0.00 and 1.00, where 1.00 represented the highest level of suspicion. A binary read (flagged or not flagged) was defined on the basis of a predetermined cutoff threshold (0.40). The flagged median and proportion of AI scores were calculated for women who were healthy, those who had a benign biopsy finding, and those who were diagnosed with breast cancer. For women with a benign biopsy finding, the interval between mammography and the biopsy was used for stratification of AI scores. The effect of increasing age was examined using subgroup analysis and regression modeling.

Results

Of a total of 10,889 women, 234 had a benign biopsy finding before or after screening. The proportions of flagged healthy women were 3.5%, 11%, and 84% for healthy women without a benign biopsy finding, those with a benign biopsy finding, and women with breast cancer, respectively (P<.001). For the 8307 women with complete information, radiologist 1, radiologist 2, and the AI CAD system flagged 8.5%, 6.8%, and 8.5% of examinations of women who had a prior benign biopsy finding. The AI score correlated only with increasing age of the women in the cancer group (P=.01).

Conclusions

Compared to healthy women without a biopsy, the examined AI CAD system flagged a much larger proportion of women who had or would have a benign biopsy finding based on a radiologist’s decision. However, the flagging rate was not higher than that for radiologists. Further research should be focused on training the AI CAD system taking prior biopsy information into account.
An eHealth App (CAPABLE) Providing Symptom Monitoring, Well-Being Interventions, and Educational Material for Patients With Melanoma Treated With Immune Checkpoint Inhibitors: Protocol for an Exploratory Intervention Trial
Authors: Fraterman Itske , Wollersheim Barbara M , Tibollo Valentina , Glaser Savannah Lucia Catherina , Medlock Stephanie , Cornet Ronald , Gabetta Matteo , Gisko Vitali , Barkan Ella , di Flora Nicola , Glasspool David , Kogan Alexandra , Lanzola Giordano , Leizer Roy , Mallo Henk , Ottaviano Manuel , Peleg Mor , van de Poll-Franse Lonneke V , Veggiotti Nicole , Śniatała Konrad , Wilk Szymon , Parimbelli Enea , Quaglini Silvana , Rizzo Mimma , Locati Laura Deborah , Boekhout Annelies , Sacchi Lucia , Wilgenhof Sofie
Published: August 2023

Background

Since treatment with immune checkpoint inhibitors (ICIs) is becoming standard therapy for patients with high-risk and advanced melanoma, an increasing number of patients experience treatment-related adverse events such as fatigue. Until now, studies have demonstrated the benefits of using eHealth tools to provide either symptom monitoring or interventions to reduce treatment-related symptoms such as fatigue. However, an eHealth tool that facilitates the combination of both symptom monitoring and symptom management in patients with melanoma treated with ICIs is still needed.

Objective

In this pilot study, we will explore the use of the CAPABLE (Cancer Patients Better Life Experience) app in providing symptom monitoring, education, and well-being interventions on health-related quality of life (HRQoL) outcomes such as fatigue and physical functioning, as well as patients’ acceptance and usability of using CAPABLE.

Methods

This prospective, exploratory pilot study will examine changes in fatigue over time in 36 patients with stage III or IV melanoma during treatment with ICI using CAPABLE (a smartphone app and multisensory smartwatch). This cohort will be compared to a prospectively collected cohort of patients with melanoma treated with standard ICI therapy. CAPABLE will be used for a minimum of 3 and a maximum of 6 months. The primary endpoint in this study is the change in fatigue between baseline and 3 and 6 months after the start of treatment. Secondary end points include HRQoL outcomes, usability, and feasibility parameters.

Results

Study inclusion started in April 2023 and is currently ongoing.

Conclusions

This pilot study will explore the effect, usability, and feasibility of CAPABLE in patients with melanoma during treatment with ICI. Adding the CAPABLE system to active treatment is hypothesized to decrease fatigue in patients with high-risk and advanced melanoma during treatment with ICIs compared to a control group receiving standard care. The Medical Ethics Committee NedMec (Amsterdam, The Netherlands) granted ethical approval for this study (reference number 22-981/NL81970.000.22).

Trial Registration

ClinicalTrials.gov NCT05827289; https://clinicaltrials.gov/study/NCT05827289

International Registered Report Identifier (IRRID)

DERR1-10.2196/49252
Views of Specialist Clinicians and People With Multiple Sclerosis on Upper Limb Impairment and the Potential Role of Virtual Reality in the Rehabilitation of the Upper Limb in Multiple Sclerosis: Focus Group Study (Preprint)
Authors: Webster Amy , Poyade Matthieu , Coulter Elaine , Forrest Lisa , Paul Lorna
Published: August 2023

BACKGROUND

Finding enjoyable and effective long-term approaches to rehabilitation for improving the upper limb (UL) function of people with multiple sclerosis (MS) is challenging. Using virtual reality (VR) could be a solution to this challenge; however, there is a lack of reporting on the views of people with MS and clinicians on VR-based approaches and recommendations for games for rehabilitation.

OBJECTIVE

This study aims to identify common UL problems and their related current therapeutic approaches for people with MS, and to explore the opinions of people with MS and specialist clinicians on VR and obtain suggestions for the development and design of VR games.

METHODS

Separate focus groups were conducted with people with MS, recruited through the MS Society UK’s research network, and clinicians, recruited through the MS Trust Therapists in MS network. A total of 10 people with MS (2 focus groups) and 8 clinicians (5 physiotherapists, 2 occupational therapists, and 1 MS nurse in 2 focus groups) were involved. The focus groups were recorded and transcriptions were analyzed using theme-based content analysis.

RESULTS

People with MS commonly reported that their UL problems interfered with activities of daily living and resulted in the loss of meaningful hobbies such as writing. Many people with MS neglected UL exercise and found strategies for adapting to the UL impairments. Similarly, clinicians stated UL rehabilitation was neglected within their service and that it was challenging to find interesting treatment strategies. VR was suggested by both participant groups as a solution, as it was convenient for people with MS to access and it could provide a more engaging and disguised approach to exercise. There were shared concerns with cybersickness and disengagement with using VR approaches. Both groups agreed games should be meaningful and adaptable for users but suggested different VR activities, with clinicians suggesting games directly reflecting activities of daily living and people with MS suggesting more abstract activities.

CONCLUSIONS

VR was well received by both people with MS and clinicians for UL rehabilitation. Recommendations were made for the development of VR rehabilitation games which are personalized and customizable for the varying abilities of people with MS.
Spatial-Temporal Evolution Characteristics of Vegetation Coverage and Urbanization Expansion in Dongguan Based on Remote Sensing
Authors: Zhang Qiuhui , Wang Ruei-Yuan
Published: August 2023

The purpose of this study is to use the Landsat satellite image of Dongguan from 2005 to 2021, combining the dimidiate pixel model and stochastic matrix method, to calculate the vegetation coverage grade and land use type area, express the urbanization process with construction land, and analyze the relationship between the temporal and spatial evolution characteristics of vegetation coverage and urbanization expansion. The results indicate that: (1) The overall distribution of vegetation coverage is consistent, showing a spatial distribution characteristic of "high in the east, low in the west, and lowest in the north". (2) During this period, the overall coverage area of medium low, medium, and medium high vegetation decreased, while both low and high vegetation coverage areas increased. (3) The area of construction land has increased significantly, with the increased built-up area coming from bare land, followed by vegetation and water bodies. (4) The spatio-temporal evolution characteristics of vegetation coverage are closely related to urbanization expansion. This study can provide reasonable scientific data support and an effective decision-making basis for evaluating the regional ecological environment, construction, and urban development of Dongguan City.
First record of a complete humerus of Agriotherium (mammalia-ursidae) from the early-late Hemphillian of Zacatecas, Mexico
Authors: Carranza-Castañeda Oscar , Wang Xiaoming
Published: August 2023

A complete humerus referred to Agriotherium is described, collected from early-late Hemphillian deposits from Zacatecas. Agriotherium is widely represented by isolated molars, mandibles, and maxillae in early-late Hemphillian faunas of Eurasia and North America. In the literature, postcranial elements are scarce and briefly described with little detail. The greatest diversity is known from the Langebaanweg quarry in South Africa; however, the only complete specimen is from Mexico. The proximal end is described, and the humerus shares similarities with the description of the distal end from South Africa, in which the medial epicondyle and crest of the lateral epicondyle are reduced, which can be considered as a limitation in the hunting of larger prey for food. This implies that Agriotherium was not strictly carnivorous but was a predator-scavenger with an omnivorous diet that included plants and fruits.
Mapping the mineralogy in the Oxia Planum and Mawrth Vallis ExoMars landing sites – implications for aqueous alteration and paleoenvironmental evolution
Authors: Reyes Ayala Karen Itzel , Kajdič Primož , Urrutia Fucugauchi Jaime , Martínez Frías Jesús , Vago Jorge L. , Durand Manterola Héctor , González Torres Enrique Alejandro
Published: August 2023

Mineralogical studies constitute one of the main tools to investigate geological processes on Mars. Here, the mineralogy of the ExoMars landing sites Oxia Planum and Mawrth Vallis is analyzed based on multispectral datasets of the CRISM Compact Reconnaissance Imaging Spectrometer for Mars of Mars Reconnaissance Orbiter, TES Thermal Emission Spectrometer of Mars Global Surveyor and OMEGA Visible and Infrared Mineralogical Mapping Spectrometer of Mars Express are integrated and interpreted. Primary and secondary minerals of carbonates, oxides, silicates and sulphates mineral groups are characterized, with most minerals produced by aqueous alteration, with 35 mineral species identified, amongst which phyllosilicates are the dominant group.  Coexisting mineral types point to distinct hydrothermal and alteration stages. Our investigation supports that water must have been present on early Mars on superficial and endogenous processes, causing direct precipitation and transformations of secondary minerals, with some not usually formed simultaneously. Hence, it is likely that species may have arisen at different times, due to changes of Martian climate. Some minerals may have formed in the subsurface. The Martian palaeoenvironments might include subaerial, underwater, and shallow subsurface hydrothermal systems, cold springs, alkaline lakes, sabkhas, and playas.  Our results contribute to our understanding of the planned landing sites to prepare for what the ExoMars rover mission may encounter, highlighting the impact that water may have had on the mineral genesis, alteration processes and their astrobiological potential.
Aplicación del Internet de las Cosas en Telecomunicaciones en Instituciones de Educación Superior
Authors: Camacho Escoto José Jaime
Published: August 2023

Este artículo presenta un panorama de las posibles aplicaciones que puede tener el uso de Internet de las Cosas (IoT) en las Instituciones de Educación Superior (IES). Se abordan mecanismos que pueden incorporarse en la enseñanza de IoT en las IES. Además, se muestran casos de aplicación de trabajos previos, en los que los autores utilizaron la tecnología para moverse de un salón tradicional a salones con enseñanza a distancia. Este último ha probado tener mejores resultados, en lo que respecta a comprensión de los temas. Las herramientas pueden ir desde el uso de clases grabadas hasta el uso de sensores e inteligencia artificial para evaluar la atención de los estudiantes. Por último, se muestra la incorporación de los laboratorios virtuales para la enseñanza a distancia, lo que permite continuar aplicando los conocimientos, incluso si el estudiante no puede asistir presencialmente a las instalaciones de la IES.
Configuración de un cluster confederado para HPC con SLURM
Authors: Flores Salgado Yolanda , Fraustto del Río Silvia Elizabeth , Ireta Moreno Joel , Itehua Rico Leobardo , Oliver Hernández Héctor Manuel , Ortega Alarcón Eduardo Iván , Romero Arzate Eduardo
Published: August 2023

El Laboratorio Nacional de Cómputo de Alto Desempeño (LANCAD) es un consorcio conformado por tres instituciones con amplia experiencia en supercómputo: el Centro de Investigación y Estudios Avanzados del IPN (Cinvestav), la Universidad Autónoma Metropolitana (UAM) y la Universidad Nacional Autónoma de México (UNAM). LANCAD se creó con el objetivo de apoyar la investigación científica nacional proporcionando servicios de cómputo de alto desempeño (CAD). Con la finalidad de explorar la integración de equipos de cómputo instalados en cada uno de los centros, el grupo técnico del LANCAD desarrolló un prototipo de cluster (1) confederado para que los usuarios ejecuten procesos indistintamente en cualquiera de los clusters CAD que lo conforman en un ambiente estandarizado. El presente artículo resume las experiencias que generó la implementación de la federación de clusters mediante el uso de Slurm Federated Scheduling, así como los retos que surgieron para su construcción, validación y pruebas.
La innovación como factor decisivo de las organizaciones en países emergentes
Authors: Franco López Jorge Ariel , Uribe Gómez Julián Alberto
Published: August 2023

Cualquier campo que requiera renovación debe incursionar en procesos que contengan innovación. La investigación tuvo como partida la pregunta ¿qué factores determinan la innovación organizacional en una economía emergente?, el objetivo fue desarrollar un modelo que explique la innovación como variable dependiente de un sistema de variables o categorías independientes para economías emergentes, utilizando un modelo de regresión lineal múltiple. Para la aplicación de la metodología se extrae bibliográficamente un sistema categorial pertinente y medible conformado por nueve variables independientes. La información se obtuvo en 40 organizaciones y 65 registros con preguntas tipo escala Likert. Los datos muestreados para las distintas variables se encuentran moderadamente homogéneos. Hay una relación lineal entre la variable innovación y el subconjunto de variables independientes. El modelo indicó que las variables independientes que más influyen en la innovación es infraestructura física, adaptabilidad al cambio, e investigación y avance tecnológico.
Un modelo multicriterio para la selección de candidatos: aplicación a un concurso docente en la Universidad Nacional de Córdoba
Authors: Curchod Miguel Angel , Carignano Claudia Etna , Alberto Catalina Lucía
Published: August 2023

En este trabajo se propone un método de decisión multicriterio discreto para facilitar la tarea de decidir en grupo la selección de candidatos a determinado puesto de trabajo. El objetivo del grupo decisor es acordar un orden de mérito de los aspirantes. En el modelo propuesto se utiliza distancia a un ideal para lograr un orden mérito individual. Se sintetizan e integran las prioridades individuales proporcionadas por los múltiples evaluadores en una decisión única mediante la aplicación de la media geométrica. El método desarrollado no presenta reversión de rango.

La metodología se aplica a un caso real de selección de postulantes a cargos docentes. Se observó que el modelo facilita la tarea del tribunal y otorga transparencia y legitimación del dictamen final. Desde el punto de las decisiones grupales, el orden final resulta equitativo si se considera que se construye y se conforma a partir de las decisiones individuales de cada evaluador
La responsabilidad social corporativa: estrategia de competitividad y creación de valor
Authors: Sánchez Ambriz Gerardo , Pérez-Balbuena José de Jesús
Published: August 2023

El presente informe de coyuntura forma parte de una investigación en curso sobre la responsabilidad social de las organizaciones y el papel estratégico de su aplicación para la generación de valor y gestión eficaz de la reputación empresarial en el contexto de la interacción dinámica con los públicos y comunidades en que las empresas se hallan inmersas. La investigación es de tipo bibliográfico con alcance descriptivo y diseño de investigación es no experimental, con un estudio transeccional.
Evaluación de estrategias de una asignatura experimental impartida a distancia
Authors: Amezcua Hempel Heidi Johanna
Published: August 2023

El contenido del artículo diserta una evaluación sobre sobre la metodología diseñada para la realización de las prácticas de laboratorio de Bacteriología a distancia. La investigación es de tipo mixta (documental y de campo). Su alcance es descriptivo, el diseño de investigación es no experimental y su enfoque es cuantitativo. La hipótesis es: En los escenarios actuales enmarcados por la pandemia de COVID el diseño e implementación de prácticas de laboratorio de Bacteriología a distancia permitirá el aprendizaje significativo en alumnos de la Licenciatura en Bioquímica Diagnóstica. La metodología construida se utilizaron vídeos tutoriales con contenido práctico del área ciencias biológicas, análisis de artículos, descripción de imágenes representativas del contenido de la práctica y realización de algoritmos de identificación bacterianos. Posteriormente para evaluar si la metodología fue adecuada se elaboró un cuestionario enviado a los alumnos. Como conclusión, los resultados permitieron observar que es posible aplicar la metodología descrita para desarrollar los contenidos prácticos en la enseñanza no presencial, pero queda pendiente la consolidación de las prácticas.
Hernia diafragmática congénita de presentación tardía. Reporte de caso con revisión de la literatura
Authors: del Real-Machain Valeria , Bolaños-Pano Luis Octavio , Parra-Ibarraran Arianna , Mercado-Cruz Eduardo
Published: August 2023

A congenital diaphragmatic hernia occurs when the diaphragm has a structural defect that allows the migration of abdominal organs into the chest cavity. It is called a ""late presentation"" when its diagnosis is within 30 days of being born. More than 60% of patients with congenital diaphragmatic hernia are misdiagnosed. The most common misdiagnoses are pleural effusion, pneumonia, pneumothorax, pneumatocele, and lung abscess. We present the case of a 3-year-old female who attended the emergency room due to abdominal pain, nausea, vomiting, intolerance to the oral route, and respiratory distress. The chest X-Ray showed migration of the gastric chamber towards the thorax, displacement of the cardiac silhouette and the mediastinal structures to the right, and the tip of the nasogastric tube located in the left hemithorax. The doctors concluded a late presentation diaphragmatic hernia. The patient received surgical treatment, which was successful. This paper highlights the importance of suspecting the diagnosis of late-onset congenital diaphragmatic hernia when treating pediatric patients with respiratory distress without another apparent cause, abdominal pain, nausea, and vomiting.
Key words: Late-onset congenital diaphragmatic hernia; respiratory distress syndrome; acute abdominal pain; pediatrics.
Loan Eligibility Prediction Using Machine Learning
Authors: Kiran Mr. V. Sravan , Reddy B. Teja , Kumar D. Uday , Varma K. Sai Avinash , Kiran T. Sheshi
Published: August 2023

Abstract: Lending research has become a highly essential research area since it may assist prevent loan defaults and grant loans to those who would pay on time. Therefore, for it though, we devised a technique for machine learning known as the random forest method, and also the data was used in this. Whatever is necessary is gathered from internet sites, and the data gathered is normalized before being employed for researching and predicting output, and it is then delivered to the random forest method, which is employed in our research. Following that, we may use the program to determine if a person is eligible for a loan or not, and a bank might not exclusively target the wealthy. Clients are accessed for loan purposes, but it also accesses other aspects of a client, that play a significant role in credit giving choices and lending prediction tax evaders.
A Study on the Smart City Project Evaluation Method based on Demand for Proptech Technology using Fuzzy Measurement
Authors:   Residential Environment Institute Of Korea, Kim Jaehwan , Shim Heecheol
Published: August 2023

This study established an evaluation system for preliminary evaluation of projects combined with smart city based on demand for proptech technology, and suggested a customized evaluation method that can be used for future regional projects. As the main result, first, the evaluation system was established by dividing it into three areas for the establishment of the evaluation system: proptech technology field, smart city living lab field, and smart city business plan field. In addition, the analysis results for this were presented as 0.609 for the internal evaluation field in the proptech technology field, 0.420 for the evaluation field of participation factors in the smart city living lab field, and 0.410 for sustainability in the smart city business planning field. Finally, a customized evaluation system was proposed with an emphasis on methodological application and provision of alternatives, and its utilization method was verified.
A Study on Determining Factors for the Location of Logistics Real Estate
Authors:   Residential Environment Institute Of Korea, Han Chung Hui , Oh Yun Kyung
Published: August 2023

As the frequency of face-to-face transactions decreased, offline commerce decreased, and as online commerce continued to increase, the e-commerce industry, such as Coupang, also grew in earnest. As the logistics demand of individuals and companies increases together, logistics industry officials are continuously striving to develop new logistics real estate and expand its scale in order to respond to customer demand. Accordingly, a survey was conducted on executives and staff members in the logistics industry to derive the main factors in determining the location of the logistics real estate, and to provide correct information to suppliers and consumers. In this study location factor data was collected through a questionnaire survey method targeting executives and employees in the logistics industry, and based on this, potential factors for logistics real estate location were analyzed and major location determinants were derived. Exploratory factor analysis was performed based on survey data on logistics and real estate locations. As a result of factor analysis on logistics and real estate locations, it was found that latent factors for measurement items were grouped into 7 latent factors based on the explanatory power of the total variance of about 60%.