bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustainable Habitat Management in the Ecuadorian Coastal Region From Local Development
Authors: Gómez Pedro José Rodríguez , Pinoargote Gabriela Electra Medina , Yero Adela María García , Riverón Guberto Cánovas , Rebolledo Washington Juan Gil , Gómez José Andrés Rodríguez
Published: September 2024

Objective: The purpose of the research is to demonstrate the use of sustainable habitat management systems with alternative and traditional materials in Latin America that serve as references for their use in Ecuador, from local development.
 
Theoretical Framework: Based on sustainable habitat management systems, this study focuses on the use of sustainable building materials as a response to habitat problems is one of the urgent alternatives for Ecuador.
 
Method: The methodology adopted for this research was based on the importance of sustainable habitat management in the Ecuadorian coastal region from local development. This is done through the review of existing related information from secondary sources of bibliographic and informative nature to later proceed to issue general conclusions.
 
Results and Discussion: The management of sustainable habitat is an alternative for the local development of autonomous governments by allowing to build decent, durable and comfortable homes, use own resources and not require highly specialized labor and be in correspondence with the traditions of the country.
 
Implications of the research: This study shows that the country has a high production of rice, whose residues are not used efficiently, causing environmental pollution.
 
Originality/Value: Also as a result, two houses built, in 1992 and 2020 respectively, that have validated the feasibility of the proposal. A flexible system is achieved, low energy consumption, resistant, with characteristics that favor the acoustic and thermal insulation and good aesthetic finish.
The Janus Face of Morality & the Two Roots of Moral Foundations
Authors: Çağlar Mustafa Emre
Published: September 2024

Purpose: The intrinsic dynamics of altruism have not been adequately addressed in the morality literature. This study reduces the gap by constructing a framework, in the triangle of self, sacrifice and morality.   Theoretical Framework: Regular meditative processes accompanied by a mantra, increases the value projection capacity of the self, and therefore increases the value attributed to human and transcendent conceptions; while liberals and conservatives project different levels of value on these conceptions in the first place. As a result of the increase, sensitivity to the difference between things that happen and (moral) things that should happen increases and attempts to bridge this gap, often require altruism.   Method: To test this framework, altruism level of 230 subjects towards 'human' and 'transcendent conceptions' (THCS) was measured and associated with the MFQ, and the frequency of transcendental meditative experiences of the same sample was questioned.   Results and Discussion: While sacrifice towards human was equally correlated with five foundations of the MFQ, sacrifice towards transcendent conceptions correlated at a higher level with only the binding foundations. It was also observed that those who conduct transandantal-meditative states via various rituals, and especially those who experienced ‘awe’ during these processes, achieved significantly higher scores on both the THCS and the MFQ as a whole. Finally, the morality literature was assessed with the help of the current theoretical framework.   Research Implications: It seems that ancient rituals are powerful tools for the establishment of morality.   Orginality: The relationship between morality and ‘religious ritual induced awe’ has been questioned statistically for the first time through the MFQ.
Правовые особенности института трудового договора: юридическое и управленческое значение документа
Authors: Пугин Дмитрий Александрович
Published: September 2024

This study provides an analysis of current trends in the development of employee-employer agreements. The comprehensive assessment includes consideration of the theoretical basis of the concept of employment contract and its development as a management tool and the ways to improve this legal term. A comparative analysis of the current employment and civil law contracts has been made. As a result of the study, we managed to make a detailed analysis of the current status of the employment contract in Russia, as well as to consider the effective contract as an alternative to the employment contract.
Мал золотник, да дорог? Отдача от масштаба производства в сельскохозяйственных предприятиях Амурской области
Authors: Васильева Ольга Геннадьевна , Билько Андрей Михайлович
Published: September 2024

The article attempts to answer the question about returns to scale in corporate farms in the Amur region. To answer this question, we use microeconomic panel data describing the performance of 132 corporate farms in the region from 2008 to 2020. We estimate the parameters of the production function and test the hypothesis of constant returns to scale. The obtained results do not allow us to reject the hypothesis of constant returns to scale. This may indicate a shift in technology and (or) efficiency compared to the early 2000s, when decreasing returns to scale were documented.
Применение процесса зеленой ферментации для производства жирорастворимых витаминов
Authors: Максименко Анастасия Александровна , Подволоцкая Анна Борисовна , Сон Оксана Михайловна , Гончаренко Софья Игоревна , Стёпочкина Варвара Дмитриевна , Шинкарук Павел Алексеевич
Published: September 2024

Vitamins represent a group of essential nutrients necessary for maintaining normal metabolism and optimal health in humans and animals. They find wide applications in the food, cosmetic, feed, chemical, and pharmaceutical industries. Recently, the global demand for vitamins has significantly increased, leading to a growing interest in finding new production strategies. Traditional methods of chemical synthesis of vitamins involve high temperatures, pressurized reactors, and the use of non-renewable chemicals or toxic solvents, raising concerns about product safety, environmental pollution, and the generation of hazardous waste. In response to these challenges, innovative approaches are emerging. Factories producing microbial cells for vitamin production offer an environmentally friendly and sustainable alternative from both an ecological and economic perspective. Advances in biotechnology and metabolic engineering have paved the way for the development of efficient and environmentally friendly processes. Fat-soluble vitamins, such as vitamins A and D, can potentially be produced using microbial cell factories or are already being manufactured in commercial fermentation processes. This overview provides a brief review of fat-soluble vitamins and thoroughly examines specific examples and achievements in this field. Additionally, the review explores metabolic engineering as the foundation for establishing vitamin production factories from microbial cells, highlighting their potential to compete with traditional chemical methods. The modern state and challenges arising in fermentative vitamin production are also discussed in detail, shedding light on current efforts to meet the growing global demand, with a focus on sustainability and safety.
Analisis Kanvas Model Bisnis Unit Usaha Damar Segaran Gallery
Authors: Kirana Desty , Agrina Camelia Rizki
Published: September 2024

Desa Sukomulyo menghadapi berbagai tantangan dalam pengembangan dan pengelolaan usaha, meskipun desa ini memiliki potensi bisnis yang besar. Pendampingan dan pelatihan menggunakan Kanvas Bisnis Model akan membantu memaksimalkan peran Damar Segaran sebagai unit usaha dari BUMDesa di Desa Sukomulyo sebagai marketplace untuk dapat meningkatkan efisiensi operasional, dan meningkatkan daya saing produk UMKM di pasar. Pendampingan dan pelatihan dilakukan untuk mengoptimalkan peran Damar Segaran, unit usaha BUMDesa di Desa Sukomulyo, sebagai lokapasar. Analisis Kanvas Model Bisnis digunakan untuk memetakan proses bisnis, mengidentifikasi kelemahan, dan menyarankan strategi pengembangan. Kegiatan pendampingan dan pelatihan di Desa Sukomulyo dilaksanakan pada bulan Juli 2023 dengan target peserta adalah para perangkat Desa Sukomulyo, Pengelola BUMDesa Sukomulyo, Pegiat UMKM dan juga para Kelompok Sadar Wisata (Pokdarwis) di Desa Sukomulyo. Diharapkan hasil analisis ini dapat membantu BUMDesa dalam memahami proses bisnis, meningkatkan kinerja, dan mencapai tujuan pengembangan. Melalui pendekatan ini, BUMDesa diharapkan dapat mengatasi tantangan dan memanfaatkan peluang untuk memperkuat ekonomi lokal di era digital. Strategi yang diusulkan, seperti perluasan pemasaran, kemitraan yang lebih kuat, peningkatan kualitas produk, pengembangan produk baru, program loyalitas pelanggan, dan optimasi biaya, dapat menjadi panduan bagi BUMDesa dalam menghadapi dinamika pasar dan meningkatkan daya saing.
Edukasi Sistem Manajemen dan Pengelolaan Sampah Berbasis 3R (Reduce, Reuse dan Recycle) di SDN 015 Sidodadi Kota Samarinda
Authors: Jusuf Jeane Betty Kurnia , Anita Salehah  , Devy Indah Paramitha  , Tasya Karunia Ramadhanti  , Alysa Alifta Prameswari
Published: September 2024

Sampah merupakan salah satu masalah klasik di Indonesia khususnya kota samarinda. Masih kurangnya kapasitas pengangkutan serta kepatuhan Masyarakat dalam menciptakan lingkungan bersih mejadi masalah utama. Perlu dilakukan pendekatan bottom up guna menciptakan kesadaran akan peduli sampah di Masyarakat. Oleh karena itu, pengabdian ini dilakukan untuk memberikan edukasi kepada Masyarakat agar dapat mengubah perilaku sadar sampah. Adapun target dalam kegiatan ini ialah lingkungan sekolah dengan berfokus pada siswa Sekolah Dasar karena tim melihat bahwa kesadaran peduli sampah harus dimulai dari usia dini. Selain siswa, kegiatan ini juga berfokus pada pemberdayaan guru dengan memberikan pelatihan mengubah sampah menjadi media pembelajaran yang menarik serta bernilai ekonomis. Diharapakan kegiatan ini memiliki dampak keberlanjutan guna mendukung upaya pemerintah kota dalam menciptakan lingkungan yang bersih bebas sampah.
Pelatihan Manik-Manik Motif Kalimantan sebagai Upaya Pengembangan Kreatifitas Anak Imigran Indonesia di Malaysia
Authors: Khatimah Khusnul , Amin Khairul , Rachman Dzul , Nabila Ashifa , Fadilah Evan Ikhsan
Published: September 2024

Tujuan dari kegiatan pengabdian masyarakat ini adalah untuk meningkatkan konsentrasi siswa dengan mengajarkan keterampilan buah melon khas Kalimantan Timur berupa cincin dan gelang. Pengabdian masyarakat ini dilakukan di Kuala Langat Learning Studio, Malaysia. Metode yang digunakan adalah metode ceramah dan demonstrasi yang melibatkan 41 siswa berusia 6 sampai 13 tahun.  Kegiatan ini tidak hanya mengembangkan keterampilan dan kreativitas kerajinan anak-anak, tetapi juga mengenalkan mereka pada warisan budaya Indonesia. Dengan menggunakan motif Kalimantan, anak-anak belajar memahami dan melestarikan tradisi melalui karya seni yang mereka ciptakan. Karya-karya ini merupakan simbol kebanggaan, hasil kerja keras mereka selama menjalani pelatihan, dan bukti nyata kemampuan mereka dalam berkreasi dan berinovasi.
Integrasi PLTS Portabel "Silangat Power" Untuk Pengisian Daya Perangkat Elektronik di Dusun Masaping, Loa Duri Ulu Kabupaten Kutai Kartanegara
Authors: Arbansyah  , Verdikha Naufal Azmi , Sumadi Muhammad Taufiq , Waloyo Hery Tri , Ilham Muhammad Fauzan Nur
Published: September 2024

Desa Masaping dan Desa Loa Duri Ulu di Kecamatan Loa Janan, Kabupaten Kutai Kartanegara, menghadapi tantangan dalam mengakses listrik yang stabil, yang berdampak pada keterbatasan penggunaan perangkat elektronik yang semakin diperlukan untuk meningkatkan kualitas hidup masyarakat. Untuk mengatasi masalah tersebut, program ini mengusulkan integrasi Pembangkit Listrik Tenaga Surya (PLTS) portabel sebagai solusi energi terbarukan yang dapat diandalkan dan ramah lingkungan. PLTS portabel ini akan diintegrasikan dengan teknologi Internet of Things (IoT) untuk memonitor dan mengoptimalkan penggunaan energi secara efisien. Tujuan utama dari program ini adalah menyediakan sumber energi alternatif yang dapat digunakan oleh masyarakat untuk mengisi daya perangkat elektronik, serta memberikan edukasi mengenai penggunaan teknologi energi terbarukan dan IoT. Metode pelaksanaan meliputi identifikasi kebutuhan energi, instalasi dan pengujian PLTS portabel, serta sosialisasi kepada masyarakat mengenai operasional dan pemeliharaan sistem. Dengan adanya program ini, diharapkan masyarakat Desa Masaping dan Desa Loa Duri Ulu dapat memperoleh akses energi yang lebih stabil dan mandiri, meningkatkan efisiensi penggunaan perangkat elektronik, serta meningkatkan kesadaran akan pentingnya energi terbarukan dan teknologi IoT. Evaluasi keberhasilan program akan dilakukan melalui pengukuran tingkat penggunaan energi, kepuasan masyarakat, serta keberlanjutan operasional sistem PLTS portabel.
STUDY AND EVALUATION OF DEVELOPMENTSAND RESEARCH ON AUDIT COMMITTEE EFFECTIVENESS DURING 2011 TO 2020
Authors: Purnomo Anugerah Septian , Arsjah Regina Jansen
Published: September 2024

The current development of the audit committee is it enough to reduce public investor panic towards information that is not in line with the expectations of public investors or only as a complement to the company's organs required by the regulator or does it play an important role in a company. This research is included in the type of literature study. during the last ten years, namely from 2011-2020 on research related to the audit committee. The research design uses a library data collection approach, uses a certain format, is formal and previously designed. This study uses secondary data with data collection techniques from accredited journal portals in Indonesia, namely Sinta 1 – Sinta 6. Overall, there are still inconsistent results among previous studies regarding the effect of audit committee effectiveness on company performance. From the side of studies that show a positive effect of the effectiveness of the audit committee on company performance, it is shown that the size, independence, and financial or accounting expertise of audit committee members can affect the quality of financial reports, earnings management, audit delay, solvency and profitability of the company, opinion going concern audit, tax avoidance, negative entrenchment effect, and CSR disclosure.
Physicochemical assessment of vegetable oil used to fry some Nigerian food items
Authors: Ojo Ayotunde Adigun , Awogbemi Omojola , Oni Taiwo
Published: September 2024

The escalating global energy demand, projected to rise from 442 EJ in 2023 to between 623 and 710 EJ by 2035, has intensified the search for sustainable energy alternatives to fossil fuels. Biodiesel, particularly from waste cooking oil (WCO), presents a promising solution due to its affordability and environmental benefits. This study investigates the physicochemical properties of neat and waste sunflower oil used to fry bean cakes (Akara), fish, and puff-puff in Nigeria, aiming to identify the impact of frying duration and fried substances on oil quality. The study’s findings reveal significant changes in the oil’s properties post-frying, with notable variations in pH, moisture content, boiling point, density, viscosity, flash point, saponification value, protein content, fat content, acid value, free fatty acids (FFA), and fatty acid methyl esters (FAME). The results indicated that the moisture content increased from 34.6% in neat oil to 47.9% in oil used for frying bean cakes, while the boiling point decreased from 243 °C to 226 °C in oil used for frying fish. The kinematic viscosity and density also varied, with the lowest viscosity (26.48 mm2/s) observed in oil used for frying fish and the highest density (911 kg/m3) in oil used for frying bean cakes. The flash point of WCO samples ranged from 248 to 258 °C compared to 260 °C in neat oil, and the saponification values varied significantly, indicating different levels of oxidation and deterioration. The study concludes that frying fish has the most detrimental effect on oil quality, as evidenced by the highest acid value (7.2 mgKOH/g) and significant changes in FFA and FAME concentrations. These insights into the physicochemical alterations of WCO highlight the potential for its optimized use in biodiesel production, offering a sustainable energy source while addressing waste disposal challenges.
C. McGinn. Is Romantic Self-Love Possible? / trans. from Engl. A. V. Nekhaev
Authors:   Omsk State Technical University, Nekhaev A. V.
Published: September 2024

The essay examines the metaphysical possibility of romantic self-love. It makes difference between two forms of such love feeling like de re and de dicto. Based on this difference, the impossibility of romantic self-love de dicto is demonstrated, since this would violate one of the constitutive conditions of such a love feeling — the requirement of the numerical distinctness between the lover and the beloved.
Activity of the Tyumen Commodity Exchange (1910–1917)
Authors:   Surgut State University, Merkulova L. V.
Published: September 2024

The article analyzes the factors and reasons that influenced the opening of the commodity exchange in Tyumen, as well as its activities in the period from 1910 to 1917. Based on the study of press materials and unpublished sources from the funds of the State Archive of the Tyumen region and the application of historical methods such as historical-comparative, historical-genetic, statistical, the aim of the study is achieved — the mechanism of the exchange is analyzed, the main directions of its activities are identified, its efficiency is assessed.
Healthcare and traditional medicine in the Tobolsk North: the view of political exiles of the late 19th century
Authors:   Surgut State Pedagogical University, Yakovchuk V. A.
Published: September 2024

This article, based on memoirs, correspondence and works of political exiles, examines the specifics of medical practice and traditional medicine in the Tobolsk North at the end of the 19th century. The point of view of patients, the dynamics of relations between them and their attending physicians in the context of the harsh natural and climatic conditions of the North and a different sanitary and hygienic culture are analyzed. The problems of alcoholism of doctors, lack of medical personnel, the negative influence of local officials and the neglectful attitude of the tsarist government are studied. Based on historical sources, the features of traditional medicine, witchcraft and shamanism, their significance in the worldview of the local population are considered. In conclusion, the general state of health care and its importance in the daily life of political exiles, the role of provincial authorities in the system of political exile in the North of Western Siberia are assessed.
Age Limitations for Presidential and Vice Presidential Candidates Post Constitutional Court Ruling Number 90/PUU-XXI/2023 A Democratic Perspective
Authors: Gusman Delfina , Oliveira Pascoal Da Costa
Published: September 2024

The constitutional right to vote or be elected is a realization of a democratic government system. Freedom exists for every citizen or government to be able to participate in the advancement of a nation. Nominating the head of state in Indonesia is a big part of political participation for every citizen nominated by their political party to be able to run for president. However, in Indonesia, certain conditions must be met for citizens running for President, one of which is a minimum age limit. This age restriction became an academic debate until the Petitioner was tested at the Constitutional Court, where he had potential disadvantages, namely not being able to run for president even though he had experience or expertise in the world of government. This research is legal research with towards statutory case analysis. The results of this research explain that the age restrictions for presidential nomination requirements in Indonesia are not only bound by formal provisions, but the Court provides an alternative consideration regardless of the age of a presidential candidate who can nominate if they have experience or are currently serving as regional heads. The implications of the Constitutional Court's Decision Number 90/PUU-XXI/2023 regarding the alternative in the form of age quality for Presidential candidacy wishes of the Community in performing their  political rights
Os entraves da administração pública brasileira para o estabelecimento das Redes de Atenção à Saúde
Authors: Rego da Silva Jonsley Moraes , Borges Ícaro Emanoel de Sousa , Castelo Branco Macedo Yolanda , De Sousa Alves Matheus , Da Silva Mileny Gomes , Borges Mariano Sarah Carolina , Ferreira Portela Vitória de Carvalho , Nogueira Luciana Tolstenko
Published: September 2024

Objetivo: Destacar a análise referente à aplicação das Redes de Atenção à Saúde no âmbito do Sistema Único de Saúde (SUS), considerando obstáculos, dinâmicas de influência e a capacidade de aprimorar a excelência dos serviços de saúde. Revisão bibliográfica: As Redes de Atenção à Saúde representam uma abordagem inovadora e estratégica para a organização dos serviços de saúde. A organização dos sistemas de saúde em redes promove melhorias significativas na qualidade dos cuidados, ao mesmo tempo em que contribui para a redução dos custos dos sistemas de administração local. No entanto, a integração entre os diferentes níveis de atenção continua sendo um desafio no que se refere, sobretudo, à dificuldade em adaptar a Atenção Especializada às necessidades locais e em promover a assistência com foco na Atenção Primária. Sob esse viés, o Complexo Regulador em Saúde revela-se imprescindível para a coordenação do acesso a serviços de saúde eficientes. Considerações finais: A revisão narrativa em questão ressalta a relevância da adaptação dos serviços no processo de implementação das Redes de Atenção à Saúde. Além disso, evidencia que as regiões de saúde são fundamentais na distribuição justa de recursos e que o processo regulatório deve ser aliado às demandas da população.
Retenção de conhecimento e habilidades do suporte básico de vida em estudantes de medicina
Authors: Jordán Arturo de Pádua Walfrido , Santos Maria Eduarda Barbosa Abrantes , Teixeira Guilherme Azevedo , Costa Maria Eduarda Rodrigues , Valentim Eliana , Souza Edvaldo da Silva
Published: September 2024

Objetivo: Analisar o conhecimento teórico e habilidades práticas, e sua retenção, sobre Suporte Básico de Vida (SBV) em estudantes de medicina do primeiro período de uma faculdade em Recife-PE. Método: Estudo quantitativo, analítico e prospectivo, com questionários teórico-prático e simulações práticas. Realizadas três mensurações, com intervalo de -1;0;4 meses, considerando-se T0 o momento após a aula de SBV. A amostra foi obtida por conveniência. Para análise, utilizou-se frequências, médias e percentuais com intervalos de Confiança (CI) de 95%, com nível de significância estatística <0,05. Estudo aprovado pelo CEP da instituição com CAAE 50685121.4.0000.5569 e parecer 4.934.326. Resultados: Dividiu-se em três fases, com “n” de 61 no pré-teste (M0), 31 (50,8% da amostra inicial) no pós-teste imediato (M1), e 18 (29,5% da amostra inicial) no pós-teste tardio (M2). Respectivamente nos momentos M0, M1 e M2, a média de acertos teóricos foi de 32,6%, 59,8% e 62,6%; e no prático, de 33,3%, 72,2% e 65,1%. Conclusão: Este estudo observou um ganho de conhecimento satisfatório imediatamente após a intervenção, bem como melhores resultados de retenção quando comparado à literatura mundial. Todavia, a minoria dos alunos alcançou a taxa de acertos mínimos proposta pela American Heart Association (AHA).
Avaliação de desfechos clínicos em pacientes com COVID- 19 com e sem diabetes melitus em um hospital de Teresina – PI
Authors: Saiki Rafael Yuri Almeida , Binsfeld Willimar Gleiser Schimidt , Vilanova Victor José Campelo , Fortaleza Monique Melo , Lima Esdras Morais Sobreiro , Milanez Isabel Maria Arruda , Câmara Felipe Tolstenko Nogueira Ayres , Parente Mírian Perpétua Palha Dias , Araújo Rogério Santiago , Nogueira Luciana Tolstenko
Published: September 2024

Objetivo: Analisar o perfil clínico-epidemiológico de pacientes internados com COVID-19 em um hospital de urgência. Métodos: Trata-se de um estudo individuado, observacional, transversal, com amostra de conveniência. Analisou-se à presença de diabetes, mortalidade por faixa etária, necessidade de internação em Unidade de Terapia Intensiva (UTI), mortalidade por tempo de internação na UTI, necessidade de Intubação Orotraqueal (IOT), mortalidade por dias de IOT, necessidade de Drogas Vasoativas (DVA). Resultados: Pacientes diabéticos apresentaram maior taxa de admissão em UTI (76,8%) do que os não diabéticos (NDM) (56%), maior necessidade de IOT (39,5%) em relação aos NDM (33,4%), maior necessidade de DVA (42%) do que os NDM (34,41%). Além disso, pacientes diabéticos apresentaram piores desfechos após admissão na UTI. Verificou-se que a quantidade de glicemias alteradas durante a internação está diretamente relacionada à maior admissão em leitos de UTI, necessidade de IOT e óbito. Conclusão: Conclui-se que a presença de diabetes e o mal controle glicêmico antes e durante internação estão relacionados a piores desfechos.
A percepção dos profissionais de enfermagem de Centro de Terapia Intensiva sobre a distanásia
Authors: Vieira Márcia Alves , Teixeira Ellen Louane , Fróes Renata Stephanie , Camargo Aline Figueiredo
Published: September 2024

Objetivo: Compreender a percepção da equipe de enfermagem do Centro de Terapia Intensiva sobre o prolongamento da vida de pacientes sem a possibilidade de reversão do quadro clínico. Métodos: Trata-se de uma pesquisa descritiva, exploratória de abordagem qualitativa. A coleta de dados foi realizada por meio de entrevistas semiestruturadas, pelo método bola de neve e aplicação da técnica do GIBI, seguindo os critérios de inclusão da pesquisa. Os dados foram obtidos através de um questionário semiestruturado previamente estabelecido após assinatura do Termo de Consentimento Livre e Esclarecido (TCLE). Os dados foram analisados conforme a análise de conteúdo proposta por Laurence Bardin. A pesquisa foi aprovada pelo Comitê de Ética em Pesquisa.  Resultados: Ao total foram entrevistados 15 sujeitos, sendo um sujeito excluído pelos critérios pré-estabelecidos da pesquisa, sendo assim, foram consideradas 14 respostas para análise. Observou-se forte aversão em relação à prática da distanásia e o fato de como a morte vem se tornando comum entre os profissionais atuantes em CTI, a correlação família x distanásia, mostrou-se altamente recorrente durante as entrevistas. Conclusão: Conclui-se que os profissionais de enfermagem participantes deste estudo corroboram para que existam práticas da distanásia em Centro de Terapia Intensiva.
Perfil epidemiológico e percepção dos usuários acerca dos serviços de diagnóstico por imagem em um hospital público do Pará
Authors: Souza Carlos Jefferson Santana de , Chermont Aurimery Gomes , Trindade Creusa Barbosa dos Santos
Published: September 2024

Objetivo: Descrever as características epidemiológicas dos usuários do diagnóstico por imagem, e expressar a percepção destes a respeito da qualidade dos serviços em um hospital público no Pará. Métodos: Trata-se de um estudo observacional, de caráter quali-quantitativo, conduzido com 83 usuários, de ambos os sexos, com idade entre 18 e 70 anos. Os usuários foram entrevistados e sua percepção foi avaliada através da aplicação de um formulário com perguntas abertas sobre cada etapa da trajetória destes no serviço. Os dados obtidos foram analisados por estatística com auxílio do software IRAMUTEQ, mediante os métodos de Nuvem de Palavras e Classificação Hierárquica Descendente (CHD). O estudo foi aprovado pelo Comitê de Ética em Pesquisa. Resultados: A amostra, com faixa de idade entre 30 a 49 anos, maioria feminina (54%), com ensino médio completo (52%), residentes na região metropolitana de Belém (60%) apresentou índices de concordância satisfatórios (88%) apenas na etapa de recepção no setor de exames. Conclusão: O estudo demonstrou níveis baixos de concordância na trajetória dos usuários e através da análise das perguntas abertas foi possível montar um banco de temáticas que servirão como base para elaboração de uma ferramenta para garantir uma melhor percepção dos usuários a respeito do serviço.
Special features of long-term follow-up in patients after surgical treatment of retinopathy of prematurity
Authors:   Voino-Yasenetsky Scientific and Practical Center for Specialized Medical Care, Moscow, Russian Federation, Sidorenko E.E. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, SidorenkoI E.I. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Krapivkin A.I. ,   Voino-Yasenetsky Scientific and Practical Center for Specialized Medical Care, Moscow, Russian Federation,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Kushchuk O.A. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Miguel D.V. ,   Voino-Yasenetsky Scientific and Practical Center for Specialized Medical Care, Moscow, Russian Federation,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Ermolaeva E.V. ,   Voino-Yasenetsky Scientific and Practical Center for Specialized Medical Care, Moscow, Russian Federation, Loskutova V.E. ,   Voino-Yasenetsky Scientific and Practical Center for Specialized Medical Care, Moscow, Russian Federation,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Le H.T. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: September 2024

Case study Special features of long-term follow-up in patients after surgical treatment of retinopathy of prematurity E.E. Sidorenko, E.I. SidorenkoI, A.I. Krapivkin, O.A. Kushchuk, D.V. Miguel, E.V. Ermolaeva, V.E. Loskutova, H.T. Le Voino-Yasenetsky Scientific and Practical Center for Specialized Medical Care, Moscow, Russian Federation Pirogov Russian National Research Medical University, Moscow, Russian Federation This article describes a long-term clinical outcomes and functional outcomes of a patient with retinopathy of prematurity stage 4, plus disease, aggressive posterior, who has a history of 2 times treatment with laser retinal coagulation in both eyes, single injection of a vascular endothelial growth factor inhibitor in both eyes and vitrectomy in left eye. As a result of regular dynamic monitoring of the patient in the long-term postoperative period, application of modern and highly informative research methods, exudative macular degeneration was detecet – retinal detachment and vision loss was prevented timely. Key words: retinopathy of prematurity, laser coagulation of the retina, intravitreal injection of vascular endothelial growth factor inhibitor, vitreoretinal surgery, optical coherent tomography, assessment of cognitive functions using the WPPSI-IV method
Compositional flexibility in irreducible antifluorite electrolytes for next-generation battery anodes
Authors: Landgraf Victor , Tu Mengfu , Cheng Zhu , Vasileiadis Alexandros , Wagemaker Marnix , Famprikis Theodosios
Published: September 2024

Solid state batteries currently receive ample attention due to their potential to outperform lithium ion batteries in terms of energy density when featuring next generation anodes such as lithium metal or silicon. One key remaining challenge is identifying solid electrolytes that combine high ionic conductivity with stability in contact with the highly reducing potentials of next-generation anodes. Fully reduced electrolytes, based on irreducible anions, offer a promising solution by avoiding electrolyte decomposition altogether. In this study, we demonstrate the compositional flexibility of the disordered antifluorite framework accessible by mechanochemical synthesis and leverage it to discover irreducible electrolytes with high ionic conductivities. We show that the recently investigated Li9N2Cl3 and Li5NCl2 phases are part of the same solid solution of Li-deficient antifluorite phases existing on the LiCl-Li3N tie line with a general chemical formula of Li1+2xCl1-xNx (0.33
RADE: A Robust Approximate Density-Functional Expansion Method
Authors: Tu Yaoquan , Laaksonen Aatto
Published: September 2024

Density functional theory (DFT) has become an extensively and successfully used tool in the studies of molecules and materials. However, DFT remains computationally expensive, especially for molecular systems comprising a few hundred atoms. Here, we present a Robust Approximate Density-functional Expansion (RADE) method, devised to substantially reduce the computational cost of conventional DFT. RADE can be implemented fully non-empirically as an efficient first-principles electronic structure method. Preliminary results for molecules containing elements H, C, N, and O indicate that this method can in general reproduce well the results from conventional DFT calculations.
Martini 3 building blocks for Lipid Nanoparticle design
Authors: Kjølbye Lisbeth Ravnkilde , VALÉRIO MARIANA , PALONCÝOVÁ MARKÉTA , BORGES-ARAÚJO LUÍS , PESTANA-NOBLES ROBERTO , GRÜNEWALD FABIAN , M. H. BRUININKS BART , ARAYA-OSORIO ROCÍO , ŠREJBER MARTIN , MERA-ADASME RAUL , MONTICELL LUCA , J. MARRINK SIEWERT , OTYEPKA MICHAL , WU SANGWOOK , C.T. SOUZA PAULO
Published: September 2024

Lipid nanoparticles (LNPs) represent a promising platform for advanced drug and gene delivery, yet optimizing these particles for specific cargos and cell targets poses a complex, multifaceted challenge. Furthermore, there is a pressing need for a more comprehensive understanding of the underlying technology. Experimental studies are costly and often provide low-resolution information. Molecular dynamics (MD) simulations allow us to study these particles at a higher resolution, enhancing our understanding. However, studying these systems at atomic resolutions is both challenging and computationally expensive, as well as time-consuming. Coarse-grained (CG) models, such as Martini 3, are positioned as promising tools for studying LNPs. To enable CG-MD studies of LNPs, accurate and validated models of their components are needed. Here, we present a substantial extension of the Martini 3 library of lipids, covering the most important LNP components, including over a hundred of ionizable lipid (IL) models, along with natural occurring sterol models and PEGylated lipid models. We furthermore present initial protocols for screening fusion efficacy across different lipid formulations and for constructing whole LNPs at CG resolution, enabling future studies of these nanoparticles.
Molecular basis of the CYFIP2 and NCKAP1 autism-linked variants in the WAVE regulatory complex
Authors: Xie Song , Zuo Ke , De Rubeis Silvia , Ruggerone Paolo , Carloni Paolo
Published: September 2024

The WAVE regulatory pentameric complex regulates actin remodeling. Two components of it (CYFIP2 and NCKAP1) are encoded by genes whose genetic mutations increase the risk for Autism Spectrum Disorder (ASD) and related neurodevelopmental disorders. Here, we use a newly developed computational protocol and hotspot analysis to uncover the functional impact of these mutations at the interface of the correct isoforms of the two proteins into the complex. The mutations turn out to be located on the surfaces involving the largest number of hotspots of the complex. Most of them decrease the affinity of the proteins for the rest of the complex, but some have the opposite effect. The results are fully consistent with the available experimental data. The observed changes in the WAVE regulatory complex stability might impact on complex activation and ultimately play a role in the aberrant pathway of the complex, leading to the cell derangement associated with the disease.
Magnetic nanoparticles (MNPs): Design, characterization, release mechanism and remote-controlled application for targeted therapeutics
Authors: Babu Abhinav , Bhardwaj Aniket , Verma Saurabh
Published: September 2024

MNPs as novel drug delivery system (NDDS) approach possess several magnetic properties for targeted and controlled delivery in various biomedical application. Unlike normal nanoparticles, MNPs enable to respond to external magnetic fields, allowing for manipulation, guidance, and functionalisation within the body. This review encompasses a wide range of scientific and technological goals aimed in understanding their properties, synthesis methods, characterization techniques, surface functionalisation strategies and application. Drug delivery based on magnetic properties has advanced dramatically to enhance therapeutic bioavailability, stability, and targeted delivwery. Converting nanoparticles into MNPs involves introducing magnetic properties to the nanoparticles through core-shell structures, doping or coating with magnetic materials, physical or chemical reactions, or biological synthesis methods. However, this study demonstrates the versatility and potential of magnetic nanoparticles (MNPs) for various biomedical applications. Moreover, the in vitro and in vivo studies highlight MNPs' promising role in targeted drug delivery, imaging contrast enhancement, and magnetic hyperthermia for cancer therapy. Moving forward, further research is warranted to optimize MNPs' design, explore novel functionalization strategies, and address challenges related to biocompatibility, scalability, and regulatory approval. Therefore, MNPs reflects transformative impact across various fields, emphasizing their potential to drive advancements in healthcare, environmental protection, and technology. Continued research and innovation in this field are expected to unlock new opportunities and address global challenges, driving progress towards a healthier, cleaner, and more technologically advanced future.
Information and communication technologies in the mechanism of criminal activity
Authors:   East-Siberian Institute of the MIA of Russia, Usachev S. I. , Usacheva E. A. ,   Irkutsk Law Institute (Branch) of the University of the Prosecutor’s Office of the Russian Federation
Published: September 2024

The possibilities of information and communication technologies and their impact on society, including the transformation of criminal activity, due to the active use of ICT capabilities by individuals and legal entities, as well as criminals for illegal purposes, are presented. It has been established that the spread of ICTs into everyday life has a number of undeniable advantages, howev-er, along with this, such technologies are increasingly becoming an instrument of criminal activity. The emergence of innovations in the digital environment naturally entails the emergence of new ways of committing crimes. It is concluded that increasing the level of citizen involvement in the use of modern technologies and platforms often produces many vulnerabilities in the digital space that are used by criminals. It has been established that in this regard, countering crimes committed using ICT will be effec-tive only in the case of an integrated approach: studying the mechanism and methods of criminal activity, increasing the level of “computer literacy” of individuals - users of the Internet space, increasing the level of knowledge of law enforcement officers, improving legislation, etc. It has been revealed that modern ICT capabilities directly affect the mechanism of criminal activity. It is concluded that the disclosure, investigation and prevention of crimes committed using ICT requires a full and comprehensive analysis, while the activities of law enforcement agencies will differ significantly for different areas.
Statements of heads of state as one of the types of international agreements: problems and suggestions
Authors:   Ministry of Economy of the Republic of Azerbaijan, Salamov N. M. ,   Azerbaijan State Pedagogical University
Published: September 2024

Using the example of the Statement of the President of the Republic of Azerbaijan, the Prime Minister of the Republic of Armenia and the President of the Russian Federation dated November 9, 2020, the legal nature of statements by heads of state was stud-ied. The relevance of the research topic is emphasized, due to the problems of statements by heads of state as one of the types of international treaties. It was revealed that when adopting this Statement, the contracting parties committed legal flaws related to the content, the expression of consent to be bound by its provisions, registration and publication. It has been established that statements by heads of state establishing, changing or terminating mutual rights and obligations, formalized in writing, are interna-tional treaties. Taking into account the principles of international law, it is concluded that, being international agreements, the Declarations fall within the scope of application of the Vienna Convention on the Law of Treaties, 1969, and the provisions of this convention must apply to them. It is recommended to conclude international agreements called Statements in the manner estab-lished by the norms of international and domestic law of the states party to the agreement. On official Internet portals where in-ternational treaties are officially published, add a form such as Statement to their titles.
On the financing of forest management activities
Authors:   Baikal State University, Kraskova A. N.
Published: September 2024

It was found that one of the results of the large-scale work carried out by public authorities in 2021 was the reform of the forest inventory system. The performance of forest inventory works remained among the expenditure obligations of the Russian Feder-ation, meanwhile, the changes affected the subjects of realization of this authority, respectively, the financing mechanism has undergone changes. The analysis is presented regarding the efficiency of the organization of forest inventory works in the period preceding the reform, aspects of financing of forest inventory activities in this period, as well as after the entry into force of changes in forest legislation in the field of forest inventory, introduced in 2021; in particular, cases of inaction of authorized pub-lic authorities were identified, as a result of which the work on forest inventory was not carried out properly. A conclusion was made as to the reasons for failure to conduct forest inventory on the lands of the forest fund, among which the key position is taken by insufficient financing. At the same time, cases of financing forest inventory activities from sources not envisaged by the legislation in force in the relevant period of time were revealed. The need for forest inventory is determined based on the need to obtain complete, comprehensive and up-to-date information on the state of forests (both quantitative and qualitative charac-teristics of forests, their territorial location) for rational management in this area. Taking into account the volume of forest inven-tory works to be carried out, as well as financial constraints, it is proposed to introduce a public-private partnership system, which will make it possible to ensure the achievement of objectives in the field of forest inventory, taking into account the limited budgetary funding.
Disadvantages of the general-purpose presumption of good faith by example of contract negotiations
Authors:   Baikal State University, Raynikov A. S. ,   Raynikov, Andreev and Partners Law Office
Published: September 2024

It is established that the distinctions between good faith in the objective sense and good faith in the subjective sense provide for different ways of proving relevant circumstances. It is proved that there can be no presumption regarding good faith in the objec-tive sense. The study revealed that good faith in the subjective sense, by contrast, is based on the assumption that the subject is bona fide. The difference in proof of two types of good faith is demonstrated by example of contract negotiations. It has been proven that there is no legal sense to place the burden of proving a good faith with regard to breach of duty to inform and ter-mination of negotiations contrary to good faith and fair dealing. It is found that the rule under which such burden is placed is random and has no analogues in civil law countries. A conclusion has been formulated according to which the general-purpose presumption of good faith becomes the cause of erroneous legislative decisions in various fields.
The characteristics of criminal activity of the Chinese mafia in Eastern Siberia
Authors:   Irkutsk branch of The all-Russian state university of justice, Anisimov A. G.
Published: September 2024

The mythology and typology of Chinese organized crime, which engages in active illegal activities within the region, are explored through a historical and cultural context. The characteristics of the formation, hierarchy, and behavior of these criminal groups are examined. The methods by which Chinese citizens illegally enter the East Siberian region are highlighted. The criminal infra-structure established to serve the interests of Chinese organized crime is analyzed in detail, as well as the methods used to con-ceal their true objectives and intentions. The means of recruiting individuals into the sphere of influence of the Chinese mafia, the establishment of control over Russian and Chinese citizens to achieve their goals, and the mechanisms for acquiring, distrib-uting, and controlling large financial flows by the Chinese mafia are described. Based on the provided description, conclusions are drawn regarding the primary activities of Chinese organized crime groups in the region. It is noted that the current level of law enforcement response is insufficient. The conclusion includes a list of recommendations for counteracting this type of crime.
Socio-legal nature of the public danger of ecological crimes and its impact on criminalization and penalization
Authors:   Irkutsk State University, Zabavko R. A. ,   Irkutsk Institute of Chemistry named after. A. E. Favorsky SB RAS
Published: September 2024

The public danger of environmental crimes is considered. It is argued that this legal category is subject to change due to so-cio-political and economic transformations of society. It is noted that the public danger of encroachments on the natural envi-ronment and the established procedure for the use of natural resources is increasing, which is associated with the increasing role of nature in the life of society, the growing need to preserve it in the highest quality condition. It is indicated that public danger directly influences the construction of elements of environmental crimes, as well as the determination of the type, size and dura-tion of punishment for their commission. The fact is stated that the social danger of the acts in question is influenced not only by the fact of its harmfulness, but also by other circumstances, in particular, the repetition of the commission. General conclusions are made that there is a need to specify the assessment categories characterizing the harm caused by environmental crimes; ac-tive use of mechanisms of administrative prejudice, special recidivism and other forms of recording the repetition of environ-mentally hazardous behavior; the need to formulate elements of crimes involving delayed environmental harm as elements of a real threat; it is necessary to take into account the consequences of the “first” level in crimes where the main harmful impact is indirect; There is an urgent need to tighten sanctions for environmental crimes in proportion to the increased importance of protected social relations.