bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementing clinical guidelines for gestational weight gain care: a novel application of Best-Worst Scaling to prioritise barriers
Authors: Farragher Eva , Wall Laura A , Wynne Olivia , Wiggers John , Hollis Jenna , Wolfenden Luke , Paolucci Francesco , Daly Justine , Mallise Carly , Attia John , Pennell Craig , Foureur Maralyn , Campbell Karen J , Kingsland Melanie
Published: September 2024

Background: Antenatal clinical guidelines recommending the provision of care for gestational weight gain (GWG) are not routinely delivered by antenatal care providers (ACPs). Determining barriers to such care delivery can inform the development of targeted strategies to improve implementation. However, no previous studies have identified which barriers are most important.
Methods: A best-worst scaling (BWS) survey was developed to estimate the magnitude and rank the importance of barriers to the delivery of recommended GWG care.
The survey was conducted between December 2020 and November 2021 with ACPs (medical, midwifery, and Aboriginal health workers) who provided care in public maternity services within three sites in New South Wales, Australia. ACPs were asked to select which of four barriers were most and least likely to inhibit five recommended GWG care practices (assessment of GWG; advice on GWG, diet and physical activity; and referral to specialist GWG services). Rankings of barriers were determined through choice frequency analysis for ACPs at each site.
Results: A total of 143 ACPs completed the survey (64.4% response rate). For each of the five recommended GWG care practices, the most important barrier across all health sites and for both midwives and medical ACPs was ‘compared to other aspects of my job, the guideline care is not a high priority.’ There was some variation in the importance of barriers between sites. Across all sites, medical staff were more likely than midwives to report ‘I forget’ as a barrier to weighing and providing weight tracking and dietary advice and ‘I don’t feel confident (providing this GWG practice)’ as a barrier to providing referrals to a specialist GWG service.
Conclusions: Best-worst scaling was a valuable method to rank the influence of barriers and to prioritise site-specific and profession-based barriers to ACP provision of guideline-recommended care for GWG. Not all barriers were equally important, and this ‘hierarchy’ differed across ACPs and sites. Implementation strategies should be developed to address the highest priority barriers, tailored to site and professional needs.
Trial Registration: Australian and New Zealand Clinical Trials Registry, ACTRN12621000054819 (22/01/2021). http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=380680&isReview=true
Service Orchestration of Customized Production with Automated Workflow Systems
Authors: Luo Ziren , Li Di , Wang Ge , Wang Shiyong , Cheng Minghao , Li Ting , Lei Zi'ang
Published: September 2024

The cloud manufacturing production mode for personalization has become the future direction of manufacturing. Workflow systems are highly regarded for conforming to the product-driven production mode. However, today's workflow systems are characterized by a low degree of flexibility and insufficient responsiveness in the face of diverse and personalized productions. Therefore, in order to address highly flexible and intelligent customized production and service preparation, this paper presents an automated workflow system. We design an automated workflow system to improve the efficiency of customized production in a new model from the traditional workflow architecture. In this way, it solves the problem that traditional workflow systems are not able to adapt themselves to service preparation in today's cloud manufacturing service crowd. Second, in order to make the process definition support the change of business requirements and improve the efficiency and accuracy, this paper designs the implementation framework of an automatic process definition and validation tool. A flexible dimensionality enhancement method based on meta mapping is proposed, which is able to enhance a 2D process information model to a 3D business process model. The process definition is validated and optimized during production generation time, and the product analysis is instantiated for completeness at runtime. Finally, this paper describes a methodology for integrating an automated workflow system into a production line and presents a reference implementation of the automated workflow system with an example of a customized product. The paper evaluates the system from both business process generation and product production perspectives, thereby demonstrating the improvement of the approach proposed in this paper for customized production.
Advancing Training Stability in Unsupervised SEM ImageSegmentation for IC Layout Extraction
Authors: Rothaug Nils , Cheng Deruo , Klix Simon , Auth Nicole , Böcker Sinan , Puschner Endres , Becker Steffen , Paar Christof
Published: September 2024

This extended paper presents a novel approach towards unsupervised SEM image segmentation for IC layout extraction. Existing methods typically rely on supervised machine learning with manually labeled training data, requiring re-training and partial annotation when applying them to new datasets. To address this issue, we propose a SEM image segmentation algorithm based on unsupervised deep learning, eliminating the need for manual labeling. We train and evaluate our approach on a real-world dataset comprising 648 SEM images of metal-1 and metal-2 layers from a commercial IC, achieving competitive segmentation error rates well below 1%. Releasing our dataset and algorithm implementations, we allow researchers to apply our approach to their own datasets and evaluate their methods against our dataset, facilitating reproducibility in the field.
Pharmacological and phytochemical investigations of methanol extracts of leaves, bulb, and root of Cymbidium aloifolium (L.) Sw. (Orchidaceae): a promising ethnomedicinal plant
Authors: Hoque Mohammed Mozammel , Rahman Md. Mahbubur , Biswas Animesh , Khan Md. Sabbir , Chakma Traya
Published: September 2024

Background
Orchidaceae member Cymbidium aloifolium (L.) Sw. has been used as a medicine in numerous cultures for a range of ailments. This research evaluates the leaf, bulb, and root of C. aloifolium methanolic extract for pharmacological and phytochemical activities.
Methods: The DPPH free radical scavenging technique assessed antioxidant activity. Protein denaturation and brine shrimp mortality experiments were used to investigate in vitro anti-inflammatory and cytotoxic effects. In vivo analgesia was tested using acetic acid-induced writhing and a tail immersion test. Anxiolytic activity was assessed using elevated plus mazes (EPM) and head-dipping.
Results
The methanolic extract of C. aloifolium leaf, bulb, and root contained alkaloids, saponins, terpenes, steroids, and flavonoids. With an IC50 value of 51.141 µg/ml, the bulb extract of C. aloifolium showed strong antioxidant activity against DPPH free radicals. The leaf of C. aloifolium showed anti-inflammatory action in vitro with an IC50 value of 22.22 µg/ml, similar to Diclofenac-Na. During the cytotoxicity experiment, it was shown that the LC50 value for the methanol extract of the leaf (200.94 µg/ml) was much higher than that of the reference medicine (42.75 µg/ml). Significant (p<0.001) findings were observed in peripheral and central analgesic action for leaf, bulb, and root was found that the methanolic extract of C. aloifolium leaf, root, and bulb increased open arm time and entries in the elevated plus maze significantly (p <0.05) compared to the control group. This showed that the 200 and 400 mg/kg doses had anxiolytic activity. Our investigation found that a 400 mg/kg dosage of C. aloifolium bulb and root leads to considerable head lowering (24.00 ± 0.52*** and 37.83 ± 0.60***, respectively, p<0.001).
Conclusion
In this research, a methanol extract of C. aloifolium leaves, bulbs, and roots showed effects as an anti-inflammatory, cytotoxic, pain-relieving, and anxiety-reducing substance in the lab.
Gender Differences in the Perceived Threats of Potential Military Conflicts Between Taiwan and China Among Taiwanese Individuals
Authors: Chen Yi-Lung , Hsiao Ray C. , Yen Cheng-Fang
Published: September 2024

Background
The relationship between Taiwan and China is increasingly tense. This study aimed to examine the gender differences in perceived threats of potential military conflicts between Taiwan and China, sources of information for the Taiwan-China relation, and the level of awareness regarding increased China’s military activities among Taiwanese individuals.
Methods
Data were collected from a representative sample of 2,000 Taiwanese nationals aged ≥ 20 years through a telephone interview survey, conducted from November 8 to 20, 2023. A computer-assisted system facilitated the survey, with stratification based on the distribution of sex, age, and location across Taiwan’s 22 administrative districts. Participants were categorized into landline and cellphone-only users in proportions that reflect national estimates. The study examined gender differences in the perceived likelihood of a war, concerns about war, perceived impacts of war on people’s lives, self-confidence in handling these impacts, confidence in politicians' ability to manage the Taiwan-China relation, sources of information about this relation, and unawareness of increased China’s military activities.
Results
The results indicated that women expressed greater concern about a potential war between Taiwan and China and demonstrated lower self-confidence in handling the impacts of such a war on their personal lives compared to men. Furthermore, women were more likely to receive information about the Taiwan-China relation from traditional media such as TV, broadcast, and newspapers, rather than from social media. Additionally, women were more likely to be unaware of the increased China’s military activities than men.
Conclusion
This study highlights significant gender differences in concerns about a potential war, self-confidence in managing its impacts, sources of information regarding the Taiwan-China relation, and awareness of China’s military activities among Taiwanese individuals. These findings underscore the need for gender-sensitive approaches in policy-making and community engagement strategies to better prepare Taiwanese citizens for the ongoing tensions with China.
Insulin prodrugs with programmed chemical release of an intramolecular cross-link
Authors: Zaykov Alexander N. , Gelfanov Vasily M. , DiMarchi Richard D.
Published: September 2024

Basal insulin therapy is conventionally achieved by one of two broad medicinal approaches that entail protracted absorption at an injection site, or through chemical modification that reduces systemic clearance. We report an alternative approach that employs novel insulin prodrug chemistry to slow the onset of glucose lowering in a controlled manner. Reversible attenuation of insulin action is achieved through a series of chemical linkers that structurally constrain the hormone until the point of their programmed chemical degradation. Under physiological conditions, dipeptide-based linkers convert at varying speed to a corresponding diketopiperazines (DKP) to initiate the transition from a constrained insulin to a flexible conformation characteristic of bioactive insulin. The experimental findings establish a path toward improved insulin-mediated glycaemic control through enhanced precision in time of action and compatible with conventional approaches to extend time action, or other therapeutic purposes.
Disentangling vibrationally-dependent molecular dynamics in mutual neutralisation reactions
Authors: Thomas Richard , Poline Mathias , Dochain Arnaud , Rosén Stefan , Ji MingChao , Cederquist Henrik , Zettergren Henning , Schmidt Henning , Larsson Mats , Ard Shaun G. , Shuman Nicholas S. , Viggiano Albert A.
Published: September 2024

Products and dynamics of mutual neutralisation (MN) reactions involving even simple molecular ions are largely unknown. Combining cryogenically stored-and-merged ion beams with coincident product-imaging addresses this issue.Application to the reaction of O2+ with O−, which occurs in atmospheric phenomena such as sprites and in high-pressure air or O2 discharge, we find that their low-collision-energy MN always leads to dissociation of the O2, governed by a two-step mechanism involving Rydberg states in O2 which couple to the final dissociation channels through Rydberg-valence interactions. We measure the partial kinetic-energy releases both in the initial e−-transfer and final dissociation steps which allows us to identify the Rydberg states. We find that the observed products depend on the vibrational levels of the O2+ ion. This type of information has not been available before, and we believe that it will significantly advance theory and models of MN processes involving small molecules.
Unraveling the Lack of Correlation between RBP4 and MASLD: Insights from Gene Expression and Serum Level Analysis
Authors: Bertran Laia , Aguilar Carmen , Auguet Teresa , Richart Cristóbal
Published: September 2024

Although previous evidence supports the involvement of retinol binding protein 4 (RBP4) in metabolic dysfunction-associated steatotic liver disease (MASLD), there are conflicting reports. Our aim was to evaluate the role of RBP4 in MASLD among a homogeneous cohort of women with morbid obesity (MO). We recruited 180 women with MO, including 40 with normal liver (NL), 40 with simple steatosis (SS), and 100 with metabolic dysfunction-associated steatohepatitis (MASH). Serum levels of RBP4 were analyzed by an enzyme-linked immunosorbent assay. RBP4 hepatic mRNA expression was evaluated by a quantitative polymerase chain reaction. In this sense, we did not report significant differences in RBP4 circulating levels between hepatic histological groups. However, analyzing RBP4 hepatic mRNA expression, we observed decreased expression of RBP4 in MASH subjects compared to those with NL or SS. To conclude, in a homogeneous and sizeable cohort of women with MO and MASLD, our findings limit, contrary to previous proposals, the key role of RBP4 in relation to MASLD and MASH pathogenesis. Therefore, new studies are necessary in other study groups to validate the absence of this correlation.
Impact of Perceived Familial Gender Discrimination and Entrapment on the Mental Health of Female Emerging Adults
Authors: Shergill Kanwal , Hooja Himangini Rathore
Published: September 2024

This study investigates the impact of perceived familial gender discrimination (PFGD) and perception of entrapment (PE) on the mental health of female emerging adults in India. The sample comprised 568 unmarried and unemployed female college students aged 18 and above, selected using purposive sampling. The research utilized the Kuppuswamy Socioeconomic Status Scale, Gender Discrimination by Parents’ Behaviours subscale, and Entrapment Short Form Scale to measure the variables. The results indicate a significant positive relationship between PFGD and PE (r = .653, p < .01), suggesting that higher levels of perceived discrimination are associated with increased feelings of entrapment. The regression analysis revealed that PFGD significantly predicts PE, accounting for 42.6% of the variance (F(1418) = 419.855, p < .05). This finding highlights the profound impact of familial gender discrimination on the psychological well-being of young women, leading to a heightened sense of entrapment. The study underscores the importance of addressing gender discrimination within families to improve the mental health outcomes of female emerging adults. Future research should explore the intersectionality of gender discrimination with other forms of discrimination and examine its long-term effects on mental health across diverse demographic groups.
Prediction of reaeration and deoxygenation rate constant in Selbe River, Mongolia: Dissolved oxygen and BOD assimilative capacity of the river
Authors: Puntsagsuren Usukhbayar , Lkhagvasuren Bodigerel , Dashdondog Gerelt-Od , Tserendorj Ariuntuya
Published: September 2024

In rivers, the processes of deoxygenation and reaeration play crucial roles in self-purification, particularly influenced by temperature changes. This study is the first to consider Mongolia's river's dissolved oxygen (DO) and biochemical oxygen demand (BOD) assimilative capacity. The objective of the study was to determine the deoxygenation rate (k1) and the reaeration rate (k2) constants of the Selbe River, in Ulaanbaatar, Mongolia. The mean k1 was calculated using two models, namely the Thomas slope and first-order function methods. The results showed that the first-order function model was more suitable for describing k1, which is 0.116 ± 0.012 and 0.266 ± 0.0281 respectively in 10 and e of logarithm base because the sampling standard deviation of the model we used is more reliable than the Thomas method. The mean k2 was estimated by 8 models out of 22 different available models. Jha’s model was more reasonable because it had the lowest sampling standard deviation compared with other models. Accordingly, the mean k2 in the Selbe River was found to be 3.41 ± 0.67 at 4.97 mean temperature of Celsius. As a result of using k1 and k2, there is 0.7 mg/L of mean critical oxygen deficit, 0.3 d of critical time, and 4.7 km of the longest distance using the purification model for steady-state at 20ºC because non-point pollution sources occurred in most sampling points. Additionally, considerations should include the trend towards stronger rainfall events, changes in land use density with an increasing number of pit latrines, variations in soil types, and the presence of private wells, all of which are potential drivers of changes in water hygiene.
Determining the empirical probability function of random samples drawn from a continuous distribution using information theory
Authors: Thuraisingham R.A.
Published: September 2024

The empirical probability of a set of random samples drawn from a continuous distribution is often estimated using a histogram. Depending on the choice of the number of bins the probability distribution function can vary. In this paper the optimum number of bins used to estimate its histogram is chosen using information theory based on Shannon entropy. It involves considering the trade-off between capturing enough detail or information and avoiding excessive uncertainty or disorder. It maximizes the gain in information content when the number of bins is varied. The method is validated by evaluating the Kullback-Leibler Divergence (KL Divergence) for random samples drawn from a number of continuous distributions. The results are also compared with other methods of evaluating the optimum number of bins. The method performs very well and provides a novel way to determine the underlying probability structure of the continuous distribution from which the random samples are drawn.
Agreement, reliability and feasibility of two protocols assessing horses’ musculoskeletal and rostral oral health
Authors: Roig-Pons Marie , Pérot Clémence , Briefer-Freymond Sabrina
Published: September 2024

Slow-feeders, a type of hay dispenser, are becoming increasingly popular among horse keepers, yet there is limited knowledge about their effects on horses’ oral and musculoskeletal health. Existing studies on this topic use varied protocols, complicating comparisons and replication. Thus, validated protocols are essential, ensuring consistent intra- and inter-rater agreement and reliability over time, while also being feasible for implementation in research. In this work, we designed a protocol for the assessment of musculoskeletal health (MSH) and adapted an existing protocol for the assessment of rostral oral cavity (incisors and gums; ROC). We evaluated the agreement between raters obtained with the two protocols, tested their intra- and inter-rater reliability using Kappa and Gwet indices, investigated their feasibility of implementation, and discussed their validity in the context of previous findings. The MSH protocol demonstrates promising inter-observer reliability and substantial intra-rater reliability, indicating consistent use by various practitioners over time. While improvements could enhance its accuracy, the protocol is accessible to those with limited experience, quick to implement, and applicable to all horse types. Preliminary results suggest that this protocol may be a valid tool for assessing MSH in horses. The ROC protocol, with the exception of one item, showed substantial to almost perfect inter- and intra-rater reliability. It has been successfully employed in two studies, yielding consistent findings on the prevalence and severity of dental abnormalities. This protocol demonstrates potential as a non-invasive method for assessing the condition of the rostral oral cavity in horses. Rater training was identified as crucial for the reliability of both protocols. Notably, the Kappa and Gwet indices produced considerably different results, suggesting careful consideration is needed when using the Kappa index to assess protocol reliability. Further research should focus on refining these protocols and exploring their broader applications to enhance their accuracy and ease of use. This study contributes significantly to the field by providing reliable, non-invasive methods for assessing key aspects of equine health, ultimately aiming to improve horse welfare. The findings emphasize the need for standardized protocols to facilitate consistent and accurate evaluations, benefiting both scientific research and practical care in the equine industry.
Assessment and Implementation of Pesticide Risk Reduction Strategies in Bangladesh's Agricultural Sector
Authors: Akter Karima , Ahmmed Abu Noman Faruq , Zaman Rabita , Ahmed Md. Saleh
Published: September 2024

The indiscriminate use of chemical pesticides in Bangladesh's agricultural sector, coupled with inadequate high-quality alternatives and extension services, poses significant challenges. National multi-institutional coordination mechanisms involving entities such as the DAE, FAO, BARC, BFSA, BINA, CABI, CIMMYT, and DoE have been established to address these issues. Efficient enforcement and monitoring of pesticide legislation necessitate extending magistracy authority to the DAE. Tomato producers, in particular, struggle with pests like late blight, with low literacy rates and adverse weather conditions hindering integrated pest management (IPM). Farmers frequently use chemicals like Imidacloprid and Cypermethrin, alongside preventive measures such as yellow sticky traps and crop rotation. Various stakeholders, including extension services and farmer organizations, play crucial roles in pesticide management. Promoting good agricultural practices (GAP) is vital to mitigate pesticide risks in cereal, vegetable, and fruit production. This study highlights the need for enhanced regulations, improved farmer education, and sustainable agricultural practices to reduce pesticide risks effectively.
MODEL PENDIDIKAN ENTREPRENEURSHIP SKILL PADA MATERI AJAR PAI DI SMK DAARUT TAUHIID
Authors: Huda Melda Nurul , Syahidin Syahidin , Kosasih Aceng
Published: September 2024

Fenomena yang terjadi saat ini di Indonesia, keterampilan siswa dalam berwirausaha masih rendah sedangkan dengan majunya teknologi dan perkembangan zaman, siswa dituntut untuk menguasasi segala bidang termasuk kewirausahaan atau entrepreneurship. Lebih miris lagi berdasarkan data Badan Pusat Statistik pada bulan Agustus 2021 menunjukkan jumlah pengangguran di Indonesia didominasi oleh lulusan SMK hal ini disebabkan banyaknya peserta didik yang tidak bisa melanjutkan ke jenjang selanjutnya dan tidak mempunyai bekal yang cukup mereka hanya siap untuk mengisi lowongan pekerjaan dibanding menciptakan lapangan pekerjaan. Penelitian ini dilakukan untuk memahami dan menelaah terkait perencanaan, pelaksanaan dan evaluasi model pendidikan entrepreneurship skill pada materi ajar PAI. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus. Teknik pengumpulan data dilakukan dengan observasi, wawancara, studi dokumentasi dan triangulasi. Berdasarkan hasil penelitian, terdapat empat model dalam pendidikan entrepreneurship skill pada materi ajar PAI di SMK Daarut Tauhiid yaitu, model PBL (Problem Based Learning), group small discussion, observasi dan praktik.
INTERNALISASI NILAI-NILAI PENDIDIKAN ISLAM MELALUI PROGRAM SHUBUH BERJAMAAH
Authors: Siregar Muhammad Era Syahputra , Nurmawati Nurmawati , Al Farabi Mohammad
Published: September 2024

Penelitian ini bertujuan untuk melihat apa saja program Subuh berjemaah dan bagaimana strategi penerapan program Subuh berjemaah Dewan Pengurus BKPRMI Kecamatan Babalan yang berkaitan dengan penanaman nilai-nilai pendidikan Islam pada remaja. Metode penelitian yang digunakan ialah metode empiris, dengan jenis penelitian kualitatif. Teknik pengumpulan data terdiri dari observasi, wawancara dan studi dokumen. Dari hasil penelitian ditemukan bahwa program Subuh berjemaah Dewan Pengurus BKPRMI Kecamatan Babalan yang berkaitan dengan penanaman nilai-nilai pendidikan Islam pada remaja se-Kecamatan Babalan dilakukan dengm pembacaan Al-Qur’an, tausiah, tanya jawab, tahsin, sarapan, ishlah, dan gotong royong. Strategi penerapan program Subuh berjamaah Dewan Pengurus BKPRMI Kecamatan Babalan dalam menanamkan nilai-nilai pendidikan Islam pada remaja se-Kecamatan Babalan, komunikasi dengan baik, ustaz dan qari terbaik, mengikutsertakan remaja. Dapat dilihat dari hasil yang dicapai pada program tersebut bahwa remaja semakin aktif ke masjid, disiplin, sopan ucap dan sikap. Faktor-faktor pendukung dan penghambat dalam penerapan program ini ialah, adanya dukungan masyarakat, sarana layak, donatur. Sementara itu, penghambatnya ialah tidak hadirnya Ustaz secara mendadak, masalah teknis seperti mati lampu, hingga adanya libur panjang nasional
KONSEP PENCIPTAAN MANUSIA (KHALIQUL BASYAR) SEBAGAI LANDASAN RELIGIOUS PENDIDIKAN ISLAM
Authors: Aliyah Adah , Hambali Adang , Suhartini Andewi
Published: September 2024

Artikel ini bertujuan memahami konsep penciptaan manusia oleh Allah dalam konteks pendidikan Islam. Metode yang digunakan adalah pendekatan kualitatif dengan jenis penlitian deskriptif, dengan pengumpulan data melalui bahasan pokok terkait materi dan analisis berdasarkan pustaka. Kesimpulan artikel bahwa manusia sebagai hamba dan khalifah Allah di bumi ini. Oleh karena itu, manusia dalam perspektif Al-Qur'an harus mencakup aspek-aspek kehidupan yang memberikan nilai-nilai yang lengkap baik di dunia maupun akhirat, serta melaksanakan tugas hidup secara individu dan sosial sesuai perintah Allah. Konsep ini berimplikasi pada pendidikan, Manusia sebagai pelaksana tugas hidup sebagai hamba Allah, memiliki dampak yang signifikan pada tujuan dan proses pendidikan. Dalam konteks ini, pendidikan tidak bisa dipisahkan dari hakikat manusia sebagai hamba Allah.
Manajemen Program Tahfidz al-Qur’an dalam Mencapai Keberhasilan Lulusan
Authors: Zauhara Fitrianti Tita , Mustofa Triono Ali
Published: September 2024

Lembaga Pendidikan saat ini, telah banyak yang menyediakan program tahfidz untuk mendukung kualitas nilai dari setiap lulusan seperti halnya di SMP Al Irsyad Surakarta. Keberhasilan dan pencapaian disetiap lulusan bisa dilihat dari siswa yang mampu menghafal al-Qur’an sesuai dengan target yang telah ditentukan. Pada penelitian bertujuan untuk memberikan gambaran mengenai manajemen program tahfidz dalam mencapai keberhasilan siswa di SMP Al Irsyad Surakarta sekaligus faktor pendukung maupun penghambat dalam pelaksanaan program tahfidz tersebut. Penelitian ini menggunakan metode kualitatif deskriptif dengan data yang berasal dari observasi, wawancara dan dokumentasi. Dari hasil penelitian ini menunjukan bahwa manajemen program tahfidz SMP Al Irsyad Surakarta sudah berjalan dengan baik dengan menggunakan fungsi dari manajemen yaitu perencanaan, pelaksanaan, pengontrolan, dan evaluasi. Faktor yang mendukung berjalannya program tahfidz adalah sarana prasarana yang memadai, waktu yang tepat dalam pelaksanaan program, murobbi yang sesuai dengan bidangnya, dukungan dari Yayasan dan orang tua siswa terhadap berlangsungnya program tahfidz, banyaknya siswa yang mengikuti rumah qur’an di luar jam sekolah, dan terpisahnya siswa laki-laki dan perempuan dalam lingkungan sekolah. Sedangkan untuk faktor penghambat bisa terjadi dari faktor internal maupun faktor eksternal. Faktor internal yaitu siswa yang telat menyetorkan hafalan karena malas sedangkan untuk faktor eksternal yaitu orang tua siswa yang kurang mendukung atas berjalannya program tahfidz.
Implementation of Prophetic Values in Educational Institutions in Improving the Morality of Students in the Era of Digitalization
Authors: Fahrudin Ahmad , Arif Moh.
Published: September 2024

Nilai profetik merupakan nilai yang dapat dijadikan pijakan dalam segala aktivitas seluruh umat manusia, khususnya dalam dunia pendidikan. Oleh karena itu penanaman nilai-nilai kenabian pada peserta didik di lembaga pendidikan Islam merupakan suatu keniscayaan di era sekarang (era digital), era sekarang menjadi tantangan bagi generasi muda khususnya peserta didik yang masih aktif belajar, dimana pemanfaatan media online sangat masif dan aktif, sehingga perlu ditanamkan nilai-nilai kenabian agar perilaku dan akhlaknya sesuai dengan nilai-nilai yang diajarkan di lembaga pendidikan. Berdasarkan hal tersebut di atas, penelitian ini menghasilkan pembiasaan nilai-nilai kenabian baik MTs Salafiyah Syafi'iyah Tebuireng maupun MTsN 4 Jombang yaitu akhlaqul karimah, keta'dhiman, ketawadhuan, olah pikir dan integritas serta nilai pesantren sebagai nilai sentral. Sedangkan implementasi nilai-nilai kenabian dilakukan melalui berbagai kegiatan pembinaan, pengajaran, furudhul ainiyah, diniyah, dan gerakan ekstrakurikuler sebagai bentuk penanaman nilai-nilai kenabian pada peserta didik serta implikasi pembiasaan dan implementasinya dapat menumbuhkan sikap dan perilaku yang selalu menjunjung tinggi nilai moral siswa di era digitalisasi ini, sikap dan perilaku dapat ditunjukkan oleh siswa baik itu sendiri, pergaulan maupun penggunaan media online.
Keutamaan Guru dalam Pendidikan Islam Surah Ali 'Imran Ayat 18; Kajian Tafsir Nawawi
Authors: Lestari Cahya Dwi , Fariq Wan Muhammad , Darwis Muhajir
Published: September 2024

Krisis moralitas banyak terjadi dikalangan pelajar. Salah satu indikator penyebabnya adalah lemahnya pegangan terhadap agama dan juga kegagalan dari dunia pendidikan terutama guru. Banyak guru yang lupa akan tanggung jawabnya bahkan tidak mengetahui akan keistimewaan derajat keutamaan seorang guru. Penelitian ini bertujuan untuk mengetahui analisa keutamaan guru dalam pendidikan Islam surah Ali ‘Imran ayat 18; kajian tafsir Nawawi dan relevansinya dengan UU RI No. 14 tahun 2005 tentang guru dan dosen. Adapun penelitian ini bersifat kepustakaan (Library Research) yaitu kajian pustaka yang mengambil data-data tertulis dari berbagai literatur yang terdapat di dalam perpustakaan. Penelitian ini dilakukan dengan mencari informasi, menelaah buku, jurnal, atau lainnya yang berkaitan dengan skripsi ini. Kemudian di analisis menggunakan teknik analisis isi (Content Analysis), hermeneutik objektif, dan metode maudhu’i. Hasil penelitian ini menunjukkan bahwa ada tiga keutamaan yang terdapat dalam tafsir An-Nawawi pada surah Ali ‘Imran ayat 18 yaitu (1) Guru adalah orang yang paham dengan ilmu tauhid; (2) Ditinggikan derajatnya oleh Allah SWT; (3) Dijamin oleh Allah tentang keadilannya. Adapun ketiga keutamaan tersebut memiliki relevansi dengan Undang-Undang RI nomor 14 tahun 2005 tentang guru dan dosen.
The Level of Understanding of the Teacher Key Competences for Inclusive Education by Kosovo Teachers
Authors:   Faculty of Education, University “Ukshin Hoti” Prizren, Kosovo, Krasniqi Kadrijaj Besë
Published: September 2024

The purpose of this research was identifying the level of understanding of the teacher key competencies for inclusive education by Kosovo teachers. For this research it was used the quantitative method approach, identified 270 teachers as sample representatives and the questionnaire was used as the instrument. The findings show that the level of understanding of the teacher key competences for inclusive education by Kosovo teachers is at the low level. The t-test shows that the teachers with long work experience are more knowledgeable about inclusion than the teachers with short experience but on the other hand the teachers with shorter work experience are more supportive, collaborative and have more interest for professional development than teachers with longer work experience. The results also show that there are differences between teachers with bachelor and master degree, in their competences (knowledge, support, collaboration and professional development) as an inclusive teacher.
The Mapping Multimodal Teaching Materials for Indonesian EFL Students: A Need Analysis
Authors: Tandiana Soni Tantan , Abdullah Fuad , Andriani Agis , Hidayati Arini Nurul , Rosmala Dewi
Published: September 2024

Multimodality has gained burgeoning attention among scholars from miscellaneous disciplines, such as Linguistics, Discourse Analysis, Semiotics, Sociology, Anthropology, Cultural Studies, and Language Pedagogy. Nevertheless, little is known about the issue of what teaching materials students need to develop their multimodal literacy, notably in the Indonesian EFL milieu. Hence, this case study addresses this void by examining what type of teaching materials university undergraduate students need to cultivate their multimodal literacy. This study involved 99 undergraduate students from three diverse classes as the participants. The data were garnered through a qualitative survey and semi-structured interviews. They were analyzed using thematic analysis (Braun Clarke, 2006). The findings outlined the needed multimodal teaching materials by the students encompass praxis-oriented multimodal teaching materials, awareness-raising multimodal teaching materials, academic and professional orientation of multimodal teaching materials, simplified and understandable multimodal teaching materials, critical multimodal teaching materials, and visual-verbal relation-informed teaching materials.  The shifting needs of communication, literacy, and 21st-century learning skills remain crucial as a nexus between literacy policies and practices in higher education contexts, especially in Indonesia. More importantly, this study attempts to promote the magnitude of multimodal literacy in language education.
Learning Ecology Perspective of Instructors to Enhance EFL Students' Speaking Skills: a Microsystem Perspective of Bronfenbrenner's Bioecological Model
Authors: Rahimi Mahmood
Published: September 2024

Learning ecology is considered a practical part of language learning, particularly speaking skills. In applicable terms, understanding ecological perspectives assists students in practicing speaking and other language skills better. Given the significance of learning ecology, this study investigates EFL instructors' perspectives on learning ecology to boost students' speaking skills using a microsystem viewpoint of Bronfenbrenner's Bioecological Model. The study stresses the gap in understanding the pivotal role of teachers' learning ecology perspectives in improving students' English-speaking skills. This study applied a qualitative research methodology with a phenomenological design to study teachers' perceptions of learning ecology. Data was collected through semi-structured interviews with EFL Instructors in Indonesia with a triangulation of data sources to ensure validity and reliability. For data analysis, thematic analysis was used to search for reoccurring themes. The findings revealed that EFL instructors in Indonesia perceive learning ecology as highly influential for speaking skills. To take maximum advantage of it, instructors in Indonesia apply strategies like interactive learning and sufficient exposure. However, they also shed light on challenges in terms of the unavailability of native speakers. Their reflection on the microsystem proposed bringing EFL speaking to a more practical context. The findings of this study contribute to our understanding of how teachers may construct a learning environment that fosters the development of ESL learners' speaking skills, influenced by Bronfenbrenner's Bioecological Model’s microsystem layer.
Transformación de la familia: el paso del modelo nuclear a uno individualizado
Authors: Guzmán Quintero Aldemar , Mondragón Duarte Sergio Luis , Guzmán Quintana Nataly
Published: September 2024

En el presente artículo se examinan las transformaciones de la familia en el contexto de la posmodernidad. Se trata de un análisis interpretativo y cualitativo de la evidencia contenida en los informes oficiales del ámbito nacional e internacional sobre las operaciones sociales y demográficas en clave de la natalidad y la mortalidad, contrastada con los marcos teóricos más relevantes de la investigación social y crítica actual, con el propósito de realizar una representación aproximada de la realidad familiar, teniendo como categorías de análisis elementos como la globalización, la migración y la biotecnología. Se concluye que estas dimensiones han dado lugar a una nueva realidad de los subsistemas familiares, en la que se distinguen sucesos que se normalizan, tales como la reducción, la diversidad y el individualismo, fenómenos que actúan como un eje de movilidad de la unidad nuclear a una globalizada.
Videogames na psicoterapia: uma revisão quase sistemática da literatura
Authors: Castro Tatiane Carvalho , Martins Yamaura Luciana Parisi , Haydu Verônica Bender
Published: September 2024

Os Videogames, além da função de entretenimento, podem tornar-se complementos relevantes da psicoterapia tradicional. Este estudo consiste em uma revisão quase sistemática da literatura que visou fazer um levantamento de estudos empíricos em que videogames foram usados como recursos terapêuticos, descrevendo o estado da arte, bem como, seu papel no processo psicoterapêutico quanto à aceitação do videogame na terapia, a aceitação da psicoterapia e a melhora da relação terapêutica. Cinco bases de dados eletrônicas (PsycInfo, Pubmed, Scielo, Web of Science e Scopus) foram usadas para a busca por estudos. Os critérios de inclusão foram definidos de acordo com a metodologia PICOS (Population, Interventions, Controls, Outcome, and Study design). A revisão incluiu artigos publicados em inglês, francês, espanhol e alemão entre janeiro de 2007 e julho de 2022. Um total de 202 artigos foram identificados inicialmente e 16 foram selecionados para a revisão, com base nos critérios de inclusão e exclusão, sendo sete experimentais e nove com metodologia qualitativa. Seis dos sete estudos experimentais e quase experimentais relataram melhora no comportamento-alvo da psicoterapia. Nos estudos com metodologia qualitativa foram relatados resultados positivos acerca da aceitação do videogame na terapia, a aceitação e motivação para a psicoterapia e/ou a melhora da relação terapêutica. Os resultados permitem concluir que os videogames utilizados como recursos para intervenções no contexto psicoterapêutico favorecem o processo terapêutico.
Towards Peaceful Coexistence: Intercultural Non-formal Education Activities for Children
Authors: Młynarczuk-Sokołowska Anna
Published: September 2024

The purpose of this chapter is to present children’s opinions (aged 7 – 12) regarding their views on the contents of intercultural non-formal education activities carried out by Polish non-governmental organisations (NGOs). The study was conducted through unstructured interviews, with 65 participants.
The results of the research show that, thanks to its character (active learning), intercultural non-formal education creates a special space for the development of intercultural competence. Its content and methods are very attractive and popular among children. It may be concluded that intercultural non-formal education carried out by NGOs can provide an inspiring alternative to classic kindergarten and school activities.
MODELOS DE MATURIDADE EM TRANSFORMAÇÃO DIGITAL
Authors: Santos Lucas Gabriel Pereira , Oliveira Rebecca Thaffenne Santos , Freitas Vérica , Freitas de Paula Verônica Angelica
Published: September 2024

Considerando a crescente relevância dos Modelos de Maturidade na promoção da melhoria e competitividade das organizações frente às transformações tecnológicas, este estudo ressalta a importância crescente de ferramentas adaptadas de Transformação Digital (TD) específicas para Pequenas e Médias Empresas (PMEs). Por meio de uma revisão sistemática da literatura, este estudo analisa Modelos de Maturidade em Transformação Digital voltados para as PMEs manufatureiras. A análise de dez desses modelos revelou abordagens focadas nas operações de manufatura, cobrindo áreas como Design, Engenharia, Gestão da Produção, Qualidade, Manutenção e Logística. Esses modelos avaliam os níveis de maturidade, que vão desde estágios iniciais até aqueles voltados para o digital, considerando aspectos como Processo, Monitoramento e Controle, Tecnologia e Organização. Este estudo identifica a importância de personalizar os planos de TD para atender às necessidades específicas de cada empresa. Ademais, destaca a necessidade constante de evolução dos Modelos de Maturidade para adaptação aos variados contextos.
Catalytic Syntheses of Pyrano[3,2-c]Quinolone and -Quinoline Derivatives and their Potential Therapeutic Agents
Authors: Aly Ashraf A. , Abd El-Naby Hisham A. , Ahmed Essam Kh. , Gedamy Sageda A. , Alshammari Mohammed B. , Ahmad Akil , Bräse Stefan
Published: September 2024

:

Pyrano[3,2-c]quinolone and pyrano[2,3-c]quinoline, as promising molecules, have garnered more
attention due to their interesting biological properties. This review dealt with the catalytic synthesis of the former
candidates in the last 20 years. Multi-component reactions (MCRs) are synthetic routes that produce a single
product from three or more reactants in a one-pot step procedure. We herein reported on the advantages of
catalysis in synthesizing the target compounds using the MCR sequence. We also discussed the mechanism and
explained the chosen catalyst's utility in the target molecules' selectivity. Finally, this recent review focuses on
the biological applications of these molecules as anticancer, antimicrobial activities, anti-diabetic, antiinflammatory,
anti-Alzheimer, and antitubercular agents.
Guettarda viburnoides Cham. & Schltdl.: Neuroprotective Activities in Mice, Molecular Docking and Microchemical and Morphoanatomical
Characteristics of Leaves and Stems
Authors: Cruz de Oliveira Junior Pedro , Janet Sanjinez-Argandoña Eliana , Alberto Marangoni Faoro Janaine , Mussury Franco Silva Rosilda Mara , Castelon Konkiewitz Elisabete , Benjamin Ziff Edward , Pereira Cabral Márcia Regina , Sarragiotto Maria Helena , de Freitas Gauze Gisele , Frederico Rozada Andrew Matheus , Mendes Monteiro Luciane , Manfron Jane , Samara Nazari Formagio Anelise
Published: September 2024

Background:

Guettarda viburnoides Cham. & Schltdl., “veludinho do campo”, is
used in the Brazilian Amazon for its effects on the central nervous system (CNS) as a “brain
tonic”; however, scientific evidence is needed to elucidate its ethnobotanical uses.

Objective:

This study evaluated the neurobehavioural effects of an ethanolic extract of G. viburnoides
(EEGV). Molecular docking, microchemical and morphoanatomical features of the
species were investigated.

Methods:

EEGV was investigated by UHPLC‒MS/MS and dereplication and molecular network
were investigated using platforms available for natural product chemistry. For the in vivo assay,
EEGV was administered to mice orally (3, 30 or 100 mg/kg). The effect of EEGV on spatial
memory was measured using the Morris water maze test in mice with scopolamine-induced amnesia.
The depression- and anxiety-like effects were assessed by forced swimming, tail suspension,
marble burying and elevated plus maze tests. The AChE inhibition was evaluated in the
brains of treated mice and molecular docking simulations were carried out with the main constituents.
The leaves and stems of G. viburnoides were analysed via optical microscopy, scanning
electron microscopy and energy dispersive X-ray spectroscopy.

Results:

Secoxyloganin, grandifloroside, hyperin/or isoquercitrin, uncaric acid and ursolic acid
were identified by UHPLC‒MS/MS. Molecular networking by three flavonoids, three triterpenes,
two coumarins, two iridoids, and one phenolic acid. EEGV reversed these scopolamineinduced
effects. In the forced swim and tail suspension test, EEGV (30 and 100 mg/kg) significantly
reduced the immobility time. EEGV significantly reduced the number of buried marbles,
while in the elevated plus maze test, no changes were observed compared to the Sco group.
AChE activity was altered in the hippocampus. Studies of the molecular coupling of iridoid glycosides
(grandifloroside and secoxyloganin) and flavonoid hyperin with AChE revealed significant
interactions, corroborating the activity indicated by the inhibition assay.

Conclusions:

These results might be in accordance with medicinal use for neuroprotetor effects
and important microchemical and micromorphological data that support the identification and
quality control of G. viburnoides.
Deciphering the Immunomodulatory Pathways of Mesenchymal Stem Cells
Authors: Yuan Fulin , Qi Qi , Wang Lei , Pan Jinhua , Shi Xiaoyu , Zhang Yu
Published: September 2024

Mesenchymal stem cells (MSCs) are adult stem cells with immunoregulatory abilities
and low immunogenicity, exhibiting powerful immunosuppressive effects in various inflammatory
diseases and holding promise for therapeutic applications. However, the detailed underlying
mechanisms remain unclear. Multiple studies suggest that the immunomodulatory function of
MSCs is primarily based on the release of immunoregulatory factors through paracrine effects,
contributing to their therapeutic outcomes. Other studies report that the immunosuppressive effects
of MSCs are mainly achieved through apoptosis, mitochondrial transfer, and the newly proposed
migrasomes, highlighting their potential clinical implications. We propose a novel hypothesis,
suggesting that migrasomes released by MSCs play a pivotal role in their immunomodulatory
ability, potentially offering new avenues for therapeutic interventions. This article primarily summarizes
the possible mechanisms by which MSCs exert their immunomodulatory effects, focusing
on MSC apoptosis, mitochondrial transfer, and migrasomes, with implications for developing novel
therapeutic strategies.