bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Thread-based Microfluidic Devices in Modern Analysis: An
Update on Recent Trends and Applications
Authors: Ahlawat Sanskar , Bhatia Rohit , Kumar Bhupinder
Published: February 2023

Background:

Inexpensive and disposable microfluidic sensing equipment is in strong demand
which can detect biomarkers of diseases found in urine or blood. From recent studies, it has been found
that multifilament threads can be used for producing low-cost microfluidic devices hence these multifilament
threads act as an inexpensive alternative. Thread has various advantages to make it appropriate to be
used in microfluidics-based technologies which include its low price, lightweight, easy availability, and
hydrophilic nature. The use of any external pumping system is avoided by the presence of capillary channels
in threads which allows the easy flow of fluid. Since thread offers more choices of materials over
paper and also paper-based microfluidics preparation is expensive therefore thread-based microfluidic
sensor has been considered more advantageous over paper-based microfluidic sensors.

Methods:

Various research reports were collected from search engines like ScienceDirect, Pub-med, ResearchGate,
and Google Scholar. Further important outcomes from these reports along with basic experimental
setup details have been compiled under different sections of this manuscript.

Conclusion:

Non-invasive or blood-free diagnosis can reduce the pain and several risk factors compared
with the traditional invasive diagnosis so it is gaining more attention regarding health status monitoring.
The various applications regarding thread-based devices include the detection of glucose and its determination,
diagnosis of diabetes and kidney failure simultaneously, food dyes separation, sweat pH and lactate
determination, selective potassium analysis, multiple antibodies detections, an assay of microbes, for
acid-base titrations, as ELISA’s platform, diagnosis of infectious diseases, ion sensing, identification of
blood types and detection of bio-samples, etc.
Gold Nanoparticles and Wound Healing in Rodents: A Systematic Study
Authors: Dehghan Hamideh , Sedighi Mahsa , Jafari-Nozad Amir Masoud , Jafari Shima , Alemzadeh Esmat , Farkhondeh Tahereh , Samarghandian Saeed
Published: February 2023

Background:

Wound healing remains a challenge that has not yet been solved. Researchers
are more interested in gold nanoparticles (AuNPs) than other nanoparticles because of
their size-related chemical, electrical, and magnetic properties that may be useful in biological
applications. Due to their antioxidant, anti-inflammatory, antibacterial qualities, and their capacity
to destroy free radicals, AuNPs are also advantageous in lowering inflammation and promoting
quicker wound healing.

Method:

In this study, we analyzed all pertinent papers up to April 2021 to study the impact of
AuNPs on the wound healing process in animal experiments based on scientific data, as wound
healing is still one of the most significant medical difficulties. Based on the keywords "Gold,
Nanoparticles, and wound healing," we carried out a systematic evaluation of the literature in
PubMed, Ovid Medline, Google Scholar, Scopus, and Web of Science databases.

Result:

This analysis shows that in all 13 studies reviewed, AuNPs significantly accelerated
wound healing, decreased wound size, and produced complete epithelialization.

Discussion:

AuNPs reduced inflammatory factors at the location of the lesion. Additionally,
groups exposed to AuNPs showed an increase in connective tissue as well as an increase in the
deposition of collagen in the wound. Different events such as the production of hair follicles,
angiogenesis, antioxidant, and antibacterial actions of AuNPs have also been observed in the
healing process of wounds. AuNPs are auspicious substances that may offer a therapeutic option
for treating wounds.

Conclusion:

To validate these results, however, an additional large sample of experimental human
research is required.
Cardiac Injury Following Chemo/Radiation Therapy: An Updated Review
on Mechanisms and Therapeutic Approaches
Authors: Singh Krishanveer , A. Alameri Ameer , Ali Hamza Ammar , E. Al-Gazally Moaed , Temurovich  Islomov Sarvar , Fadhel Obaid Rasha , Alexis  Ramírez-Coronel Andrés , Abosaooda Munther , Yahyapour Rasoul , Najafi Masoud
Published: February 2023

Cardiovascular disorders are among the critical side effects of cancer therapy. Damage
to the function and normal structure of the heart can cause serious threats to patients that are being
treated for cancer. Cardiovascular complications may be induced by various types of chemotherapy
drugs and also radiation therapy. The severity of cardiovascular toxicity depends on several
factors, such as types of drugs, tumor location for radiotherapy, the presence of cardiac disease
history, the dose of drugs or ionizing radiation, etc. Radiotherapy and chemotherapy can cause
heart diseases through various mechanisms, such as oxidative stress, inflammation, cell death, fibrosis,
endothelial to mesenchymal transition (EndMT), etc. Chronic inflammation following
damage to a huge number of cells can trigger more accumulation of inflammatory cells and chronic
release of reactive oxygen species (ROS) and nitric oxide (NO). Oxidative stress can induce
more cell death and cardiac remodeling through damage to vessels and valvular and disruption of
the normal structure of the extracellular matrix. These changes may lead to cardiomyopathy, myocarditis,
pericarditis, and vascular disorders that may lead to heart attack and death. This review
provides basic information on cellular and molecular mechanisms of different types of cardiovascular
disorders following cancer therapy by radiation or chemotherapy. We also recommend some
adjuvants and targets to reduce the risk of heart toxicity by radiation/chemotherapy.
Hydroalcoholic Extract of Achillea Wilhelmsii Decreases the Expressions
of Hippo Signaling Pathway-Associated Oncogenes in the A549 Lung
Cancer Cell Line
Authors: Nabatchian Fariba , Davoudi Maryam , Ashtiani Mojtaba , Davoudi Negin , Afrisham Reza
Published: February 2023

Background:

Achillea wilhelmsii used in traditional Iranian medicine to treat a variety of
disorders, has been proven to contribute to some signaling pathways in cancers. Evidence suggests
that the Hippo pathway, which regulates organ size, is altered in a few conditions like lung cancer. In
this regard, this study aimed to evaluate the effect of the hydroalcoholic extract of this plant on the viability
and mRNA expression of some Hippo signaling pathway-associated oncogenes and suppressors
in A549 lung cancer cell lines.

Methods:

Hydroalcoholic extract was prepared using a Soxhlet extractor and its antiproliferative activity
was studied by MTT assay. Then, the mRNA expressions of "large tumour suppressor kinases 1
and 2" (LATS1 and LATS2), "Yes1 Associated Transcriptional Regulator" (YAP1), and "Transcriptional
co‑activator with PDZ‑binding motif" (TAZ) were measured using real-time PCR.

Results:

According to MTT, the viability was decreased significantly after 24 h treatment with A. wilhelmsii
at the concentrations of 800-1000 μg/ml and after 48 h treatment at the concentration of 400-
1000 μg/ml. While the mRNA levels of LATS1, TAZ, and YAP1 decreased significantly compared to
untreated cells at the concentration of 200 μg/ml after 48 h treatment. However, the mRNA expression
of LATS2 did not change.

Conclusion:

Our findings showed that hydroalcoholic extract of A. wilhelmsii inhibited the viability of
lung cancer cells as well as it could decrease the expression of both oncogenes in the Hippo pathway.
However, it had suppressing effects on LATS1, which should be considered in further studies.

conclusion:

Hydroalcoholic extract of A. wilhelmsii might inhibit proliferation of lung cancer cells as well as it could decrease the expression of both oncogenes in them. However, it had suppressing effects on LATS1, which should be considered in further studies.
TENSION TYPE HEADACHE (TTH)
Authors: Nur Muthmainnina Auliya , Nandar Kurniawan Shahdevi
Published: February 2023

Cerebrovascular disease is the number one cause of epilepsy in the elderly population. Headaches are relatively common in patients with cerebrovascular disorders. The frequency of stroke-related headaches ranges from 7% to 65% with different types of headaches. The prevalence of persistent post-stroke headaches from 7-23%, with follow-up times ranging from 3 months to 3 years after stroke. Persistent headache in the population was associated with high depression and fatigue scores and significantly impacted returning to work. Most headaches at stroke onset will resolve, persistent headaches are a real entity even years after the stroke. The mechanism that might explain the relationship between headache and hemorrhagic stroke is still unclear, including changes in blood vessel walls supported by endothelial dysfunction in migraine sufferers as well as comorbid vascular risk factors such as arterial hypertension or platelet dysfunction. Headache after stroke intracerebral hemorrhage is believed to be the result of vasoconstriction that causes ischemia of the vessel wall.
La guerra en las ciudades
Authors: Alvarez-Calderon Carlos Enrique , Aguirre Carlos Leonardo , Coronado-Camero Faiver , Sierra-Gutiérrez William Alfredo
Published: February 2023

Este artículo aborda la relación de la guerra con las ciudades con el fin de analizar el creciente interés de los grupos armados subversivos y criminales por actuar en áreas urbanas, y cómo esto representa un desafío para la seguridad nacional. Para ello, se aborda la anatomía de las ciudades, su crecimiento, su expansión y la tendencia a una cada vez mayor urbanización en el futuro. Posteriormente se analiza la historia de la guerra urbana, su evolución moderna y su profundización en el presente y el futuro próximo. Luego se aborda el caso colombiano, con las incursiones de las guerrillas y otros grupos criminales en las ciudades. Finalmente se desarrolla el concepto de la geopolítica vertical, para entender los nuevos factores que hacen más complejo el desafío de enfrentar amenazas y acciones contra el Estado en las ciudades.
Prospectiva de ciberseguridad nacional para Colombia a 2030
Authors: Cano-Martínez Jeimy José
Published: February 2023

Este artículo presenta un ejercicio prospectivo sobre la ciberseguridad nacional de Colombia a 2030, con base en la revisión de fuentes académicas, reportes internacionales y entrevistas con especialistas. Los resultados se agrupan en seis factores siguiendo el marco Pestel: político, económico, social, tecnológico, ecológico y legal, con el fin de ofrecer un panorama integrado útil para comprender y asumir el reto de la protección del Estado y la resiliencia de las organizaciones frente a las dinámicas internacionales de la transformación digital y una sociedad cada vez más presente en el ciberespacio. Este artículo aspira a motivar nuevas investigaciones desde esta prospectiva y apoyar la toma de decisiones frente a las realidades emergentes que hoy ya hacen parte de un entorno cada vez más incierto, complejo y volátil.
Organización criminal como tipo penal idóneo en la lucha contra la delincuencia organizada en España
Authors: Giner-Alegría César Augusto , Morente-García Raúl
Published: February 2023

El delito de organización criminal en España, como tipo penal idóneo para frenar las nuevas y complejas formas delictivas organizadas, fue perfilado a partir de instrumentos internacionales, en respuesta a una nueva delincuencia altamente estructurada. Mediante un análisis normativo, jurisprudencial y de la doctrina científica de la legislación española, este artículo muestra que la nueva figura delictiva de la organización criminal es el tipo penal de mayor idoneidad, rigor y severidad para la prevención del crimen de la delincuencia organizada, y se evidencia la insuficiencia del tipo penal de la asociación ilícita, con el cual guarda similitud y cierto solapamiento. El estudio muestra que es innecesario mantener ambas figuras, y que además se requiere suprimir agravantes específicos tras la regulación independiente del delito de organización criminal.
Una aproximación psicosocial a las causas de los fallos de inteligencia
Authors: Martínez-Sánchez Juan Antonio
Published: February 2023

Este artículo aborda el concepto de fallo de inteligencia, sus rasgos y sus principales causas a partir de una perspectiva psicosocial. Desde este punto de vista, se plantea que los errores son inherentes a toda actividad humana y a la naturaleza de la inteligencia, de modo que su ocurrencia es normal e inevitable en sistemas complejos, como lo son los servicios, las agencias y las comunidades de inteligencia. Con todo, se argumenta que, si bien no se pueden evitar, es posible minimizar al máximo su ocurrencia y mitigar el impacto negativo que podrían tener. En ese sentido, se plantean algunas medidas y acciones que pueden contribuir a ese fin.
Microelements in seeds of advanced genotypes of Caupí beans (Vigna unguiculata L. Walp) established in a soil of Cordoba, Monteria.
Authors: Quiñones Avilés María , Argel Espitia María , Combatt Caballero Enrique Miguel , Aramendiz Tatis Hermes , Mercado Lázaro Jaime
Published: February 2023

The objective was to quantify the nutritional contents in seeds of different advanced genotypes of cowpea bean (Vigna unguiculata L. Walp) in the soil of Montería-Córdoba, Colombia. Seeds of 40 lines or genotypes and two commercial varieties Caupicor 50 and ICA Betancí were evaluated as controls. A completely randomized block design was used with three repetitions for a total of 126 experimental units. The seeds were initially subjected to drying in a forced circulation oven at 70 ° C for 72 hours to quantify the nutritional content. The final nitrogen content was evaluated by initially submitting the seeds to digestion in concentrated sulfuric acid for 4 hours. It was subsequently quantified using the Kjeldahl method. Finally, to determine the content of microelements, 1 g of seed was subjected to digestion with nitric, perchloric acid (3:1), and they were quantified in a piece of atomic adsorption equipment. With the information recorded in the laboratory, an analysis of variance, contrasts, and tests of Tukey averages was performed at a 5% probability. The results indicate that it existed genetic variability and genotypes LC-041-016 and LC021016 were identified with 29.2 and 29.1%, with the highest protein content, being superior to Caupicor 50 and ICA Betancí that presented contents of 25, 7 and 25.5%. The genotypes L-047 with 216.3, followed by genotypes LCPM35 and LC027016, with 159.5 and 127.3 mg.kg-1 presented the highest iron content, and the commercial witnesses Caupicor 50 and ICA Betancí, content less than the above, and the content zinc and manganese  were similar in all genotypes evaluated.
Trends in Exposure to Secondhand Smoke Among Adolescents in China From 2013-2014 to 2019: Two Repeated National Cross-sectional Surveys
Authors: Ma Chuanwei , Huang Yayang , Li Sixuan , Zhao Min , Zeng Xinying , Di Xinbo , Magnussen Costan G , Xi Bo , Liu Shiwei
Published: February 2023

Background

It is well-known that secondhand smoke exposure in childhood or adolescence is positively associated with morbidity and mortality. However, less is known about the current status of and most recent trends in secondhand smoke exposure among adolescents in China.

Objective

We aimed to assess recent changes in the prevalence of secondhand smoke exposure among adolescents in China using nationally representative data.

Methods

We used data from 2 repeated national cross-sectional surveys conducted in 2013-2014 and 2019. A total of 155,117 students (median age 13.5 years) in 2013-2014 and 147,270 students (median age 13.1 years) in 2019 were included in this study. Sociodemographic factors and secondhand smoke exposure information were collected via a standardized questionnaire. Exposure was defined as secondhand smoke exposure ≥1 day during the past 7 days at home or in public places. Other frequencies of secondhand smoke exposure (ie, ≥3 days, ≥5 days, and every day) during the past 7 days were also assessed. The weighted prevalence of secondhand smoke exposure was calculated according to the complex sample design for surveys.

Results

The prevalence of secondhand smoke exposure in any place (home or public places ≥1 day during the past 7 days) decreased from 2013-2014 (72.9%, 95% CI 71.5%-74.3%) to 2019 (63.2%, 95% CI 62%-64.5%), as did exposure at home (2013-2014: 44.4%, 95% CI 43.1%-45.7%; 2019: 34.1%, 95% CI 33.1%-35.2%) and in public places (2013-2014: 68.3%, 95% CI 66.9%-69.6%; 2019: 57.3%, 95% CI 56%-58.6%). The prevalence of secondhand smoke exposure decreased with increased gross domestic product per capita in each of the 2 survey years irrespective of exposure frequency or location. The prevalence of exposure at other frequencies (ie, ≥3 days, ≥5 days, or every day during the past 7 days) also decreased in any place, at home, and in public places. Secondhand smoke exposure was associated with higher school grade level (ninth vs seventh grade: odds ratio [OR] 1.76, 95% CI 1.68-1.84), gender (boys vs girls: OR 1.18, 95% CI 1.15-1.22), urban status (urban vs rural: OR 1.10, 95% CI 1.01-1.19), and cigarette smoking (yes vs no: OR 6.67, 95% CI 5.83-7.62).

Conclusions

Although the prevalence of secondhand smoke exposure among Chinese adolescents declined from 2013-2014 to 2019, it remains unacceptably high. More effective strategies and stronger action are needed in China to further, and dramatically, curb secondhand smoke exposure among adolescents.
Немоторні симптоми в структурі проявів різних клінічних форм хвороби Паркінсона на фоні леводопатерапії
Authors: Tarianyk K.A. , Shkodina A.D. , Lytvynenko N.V. , Purdenko T.I.
Published: February 2023

Актуальність. Немоторні симптоми хвороби Паркінсона розвиваються в структурі клінічної картини захворювання й залежать від типу обраної терапії. З огляду на той факт, що захворювання завжди розглядається як моторний дефіцит, а вираженість немоторних симптомів залишається недостатньо вивченою, метою нашого дослідження була оцінка вираженості немоторних симптомів при різних клінічних формах хвороби Паркінсона на фоні леводопатерапії. Матеріали та методи. Нами було обстежено 107 пацієнтів із хворобою Паркінсона, які перебували на обстеженні й стаціонарному лікуванні в неврологічному відділенні Комунального підприємства «Полтавська обласна клінічна лікарня ім.М.В.Скліфосовського Полтавської обласної ради» і на базі Центру для пацієнтів із хворобою Паркінсона та іншими нейродегенеративними захворюваннями на базі кафедри нервових хвороб Полтавського державного медичного університету. Були виділені акінетико-ригідна, змішана й контрольна група пацієнтів, які були порівнянні за соціодемографічними показниками, також не було встановлено відмінностей за тривалістю захворювання й локалізацією дебюту. Результати. У групах пацієнтів встановлено вищі показники вираженості немоторних ознак за підшкалами «сон/втома», «настрій», «увага/пам’ять», «гастроінтестинальні порушення», «розлади сечовидільної системи», «порушення статевої функції» порівняно з контрольною групою. Виявлено, що для пацієнтів з акінетико-ригідною формою захворювання характерне переважання розладів з боку гастроінтестинальної і сечостатевої систем, а також порушення сну, психіки й настрою, що виражається загальним балом за шкалою немоторних проявів порівняно з пацієнтами змішаної групи. Встановлено схильність пацієнтів із хворобою Паркінсона до більш вираженого депресивного синдрому порівняно з особами відповідного віку й переважання тривожного синдрому в пацієнтів з акінетико-ригідною формою захворювання — характерні клінічно виражені прояви тривоги, а для змішаної групи— субклінічні прояви. Висновки. На фоні лікування препаратами леводопи в пацієнтів із різними формами хвороби Паркінсона спостерігається значна кількість немоторних симптомів, зокрема порушення сну, психіки, сечостатевої і гастроінтестинальної систем. Пацієнти з акінетико-ригідною формою мають більш виражені немоторні симптоми й розлади афективної сфери.
Роль фармакотерапії в лікуванні пацієнтів з різними видами нейропатій і радикулопатій
Authors: Oros M.M.
Published: February 2023

Дана стаття присвячена вивченню ефективності антихолінестеразних засобів у лікуванні пацієнтів з парезами, зумовленими ураженням периферичної нервової системи, на прикладі препарату Параплексін. Висвітлено механізми дії і фармакологічні ефекти антихолінестеразного препарату Параплексін. Спостереження показали, що даний засіб характеризується ефективністю, відсутністю значних побічних реакцій і добрим профілем безпеки. Також було з’ясовано, що включення антихолінестеразних засобів у комплекс лікувальних заходів при ураженнях периферичних нервів підвищує швидкість і результативність лікування. Вищеописані характеристики дозволяють рекомендувати препарат Параплексін для лікування пацієнтів з парезами, зумовленими нейропатіями й радикулопатіями.
Можливості фармакотерапії постінсультної депресії: новий погляд на стару проблему
Authors: Burchynskyi S.H.
Published: February 2023

У статті розглянуті актуальність, концепції патогенезу та підходи до фармакотерапії однієї з найбільш значущих форм депресивних розладів у неврологічній практиці — постінсультної депресії (ПД). Детально проаналізовані погляди на ПД як на складну полікомпонентну структурно-функціональну патологію ЦНС. Наведені сучасні можливості вибору антидепресантів для лікування зазначеної форми патології в контексті критеріїв безпеки цих засобів та можливості розвитку клінічної резистентності в процесі лікування. З цієї точки зору розглянуті механізми дії, клінічна ефективність та практичні переваги вітчизняного інноваційного комбінованого засобу з антидепресивною дією — Депріліуму. Обґрунтована фармакологічна та клінічна доцільність об’єднання в одній лікарській формі (Депріліум) трьох компонентів — S-аденозилметіоніну, L-метилфолату та метилкобаламіну, які справляють комплексну взаємодоповнюючу дію на процеси біосинтезу біогенних амінів і можуть розглядатися як патогенетично обґрунтована терапія депресивних розладів. Особливу увагу приділено можливостям застосування Депріліуму як інструмента стратегії аугментації депресивних розладів, і зокрема ПД, у випадках резистентності або непереносимості терапії конвенційними антидепресантами. Разом з тим обґрунтована необхідність додавання до терапії когнітивних розладів при ПД засобу з комплексною ноотропною і ней-ропротекторною дією. З цією метою запропоновано використання вітчизняного комбінованого засобу Церебровіталу, до складу якого входять екстракти гінкго білоба та центелли азійської, а також лецитин. Описані механізми дії та переваги Церебровіталу при лікуванні когнітивної дисфункції в рамках ПД. Загалом комбінацію Депріліум + Церебровітал можна розглядати як ефективну і безпечну альтернативу можливій поліпрагмазії при фармакотерапії ПД.
Dance-терапія в комплексній реабілітації пацієнтів із хворобою Паркінсона
Authors: Sidelkovskiy A. , Gasiyk O.
Published: February 2023

Найбільш поширеним нейродегенеративним процесом у популяції є хвороба Паркінсона, що характеризується прогресуючою втратою дофамінергічних нейронів чорної субстанції стріато-палідарного комплексу. Останнім часом формується певна тенденція до збільшення кількості хворих на хворобу Паркінсона, що може призвести до зростання цієї нозологічної групи в найближчі десять років майже у два рази. Основні клінічні прояви хвороби Паркінсона — акінезія, ригідність, тремор, постуральна нестабільність і немоторні симптоми. Прояви захворювання дебютують поступово і мають прогредієнтний розвиток у часі, ускладнюючись розладами мовлення й когнітивним зниженням аж до деменції, особливо на пізніх стадіях. Лікування нейродегенеративних захворювань, у тому числі хвороби Паркінсона, залишається однією з найбільш складних проблем сучасної медицини. Реабілітаційний протокол лікування пацієнтів із хворобою Паркінсона включає розробку індивідуального плану відновлювальної терапії з обов’язковим формуванням мультидисциплінарної команди фахівців з урахуванням персоніфікованих особливостей перебігу хвороби. На початкових стадіях захворювання, коли пацієнт достатньо активний і його професійна й побутова компетентність суттєво не порушена, рекомендовано акцентувати увагу на збільшенні об’єму рухів, їх сили й витривалості. Кінезіотерапія особливо ефективна в супроводі ритмічної музики і спрямована на покращення рухової активності, м’язового тонусу, постуральної стійкості пацієнтів з проявами екстрапірамідної недостатності. Застосування елементів музичного акомпанементу справляє значний позитивний емоційний вплив на пацієнта, допомагаючи в досягненні поставлених завдань реабілітаційної програми. Музикотерапію в системі відновлювального лікування поєднують з елементами танцювальних вправ. Такий підхід у профільній літературі має назву Dance-терапія. Особливо ефективна Dancе-терапія у хворих з екстрапірамідною патологією, у цих випадках вплив танцювальних вправ на пластичність м’язового тонусу, симетричність рухів, загальну активність пацієнтів і емоційну складову більш помітний. Dancе-терапія у хворих з екстрапірамідною патологією зазвичай включає танцювальні рухи, спрямовані на відновлення симетричності, злагодженості й пластичності. Найбільш дієвими танцювальними стилями вважаються рухи з елементами вальсу, танго, фокстроту. Також ефективними є локомоторні вправи, що імітують основні рухи танців ча-ча-ча, румба і пасодобль. Індивідуальна програма танцювальної терапії розробляється мультидисциплінарною командою спеціалістів, до складу якої залучають фахівців з хореографії.
Kelompok Milenial dan Tantangan Pembangunan Kota: Gentrifikasi dan Komersialisasi Ruang di Kota Yogyakarta
Authors: Amrozi Imron , Sultansyah Dicky Riandy Prasetya , Hidayat Afifatul Millah Nurul Aulia , Savirani Amalinda
Published: February 2023

This study aims to explore gentrification in the city of Yogyakarta through the production and commercial- ization process of tourism space, explore the impact of gentrification felt by local communities in a cross-gen- erational context, and formulate strategies that millennials can do to support housing access in the city of Yogyakarta. Through the research process in Sosrokusuman Village located in the Malioboro area, this study finds that the transformation of settlements in Sosrokusuman cannot be separated from its territory within the Malioboro area as a tourism space. In addition, the exploration on the impact of gentrification for local com- munities shows that the scarcity of housing due to land conversion (commercialization) and high land prices have caused millennials with salaries equivalent to the regional minimum wage to have difficulty accessing housing in Sosrokusuman and have the potential for voluntary eviction. Meanwhile, the exploration of strat- egies that can be done to support housing access for millennials is through cross-sector collaboration with the concept of collaborative implementation program (CIP).
Isolasi atau Integrasi Sosial: Peran Kualitas Pertemanan dalam Menunjang Kepuasan Hidup Dewasa Muda Lajang di Indonesia
Authors: Kaparang Giofanny Jessica , Himawan Karel Karsten
Published: February 2023

Marriage is a normative practice in Indonesia. As a result, many view marriage as a social achievement rather than a personal choice. This attitude could impact the psychological well-being of single individuals as they receive marriage pressures and associated stigma from their communities. This quantitative study aims to explore the role of friendship quality on life satisfaction among non-dating unmarried young adults in Indonesia. Friendship Quality Scale (FQS) and Satisfaction With Life Scale (SWLS) were employed to measure the quality of friendship and the life satisfaction of 121 unmarried young adults who is not in a romantic relationship in Indonesia (Mage = 29.98; SD = 3.849), as approached through purposive sampling. Result of this study confirmed a significant contribution (49.4%) of friendship quality to the life satisfaction of male participants, but the results among the females was found insignificant.
Mandibular condylar process remodeling in rats with different bite-altering devices
Authors:   Department of Oral and Craniofacial Sciences, University of Pittsburgh, 409 Salk Pavilion, 335 Sutherland Drive, Pittsburgh PA 15213, USA, Li W , Trbojevic S , Pineda-Farias JB , Liu X , Gold MS , Almarza A
Published: February 2023

The objective was to compare different dental splint models and materials for inducing abnormal loading on the gross morphology and histological appearance of the mandibular condylar processes of Sprague Dawley rats. Three different types of dental splints (resin molar, aluminum incisor, stainless-steel incisor) were placed unilaterally to induce occlusal perturbation for 4 weeks. At that time, mandibular condylar processes were assessed by gross appearance and histology. Quantitative measurements were also conducted on the hematoxylin & eosin images for condyle shape. The results showed that although the condylar cartilage was affected by all splint types, the resin molar splint was associated with the most extensive mandibular condylar process remodeling, which was primarily a slant (skewness) of the lateral aspect of the condylar process. Additionally, quantitative measurements on the histological specimens demonstrated that the split and tilt angle of the left (ipsilateral) condylar processes in the resin molar group (124.8 ± 12.7° and 104.1 ± 12.7°, respectively) increased significantly (p < 0.05) when compared to right (contralateral) condylar processes (104.7 ± 5.8°and 91.6 ± 4.4°, respectively). However, no changes were noted on the thickness of the fibrocartilage layer at medial, central, and lateral regions of the condylar process. Another major finding is the high variability of morphology of the naïve animals. Future studies will assess the impact of longer durations of splinting, age, and sex on the remodeling of the mandibular condylar process, allowing for the development of diagnostics and therapies.
Diferencias en las atribuciones causales del rendimiento académico en alumnos de secundaria con dificultades de aprendizaje en función del tipo de dificultad y de su participación en otras actividades gratificantes
Authors: Cuadro Ariel , Leibovici Galia , Costa-Ball Cesar Daniel
Published: February 2023

Este estudio analiza las atribuciones causales en alumnos de educación secundaria y si estas atribuciones varían de acuerdo con el tipo de dificultad, así como al éxito o no en otras áreas de desempeño personal. A partir de una muestra de 371 alumnos entre 13 y 16 años, 67 de ellos con diagnóstico de dificultades de aprendizaje, se evaluaron los patrones de atribuciones causales y su relación con el rendimiento académico, como con su participación en actividades deportivas y artísticas. Los resultados muestran que a mayor dificultad mayor la atribución en considerar el esfuerzo como causa principal para alcanzar éxitos en su proceso de aprendizaje; no encontrándose diferencia en función del tipo de dificultad. Asimismo, cuando los alumnos con dificultades en el aprendizaje se sienten competentes en áreas no académicas, pueden desarrollar una mejor predisposición al logro. Esto impactaría en sus capacidades para enfrentar los aprendizajes, su percepción de competencia y procesos de autorregulación.
The moderating effect of work experience between organizational culture, safety behavior, and organizational performance of university education administration
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Chang-Hyun
Published: February 2023

Objectives The purpose of this study is to understand the relationship between organizational culture, safety behavior, and organizational performance of university education administration, and the moderating effect according to work experience.em.
Methods The subjects of the study collected data from 2021 to 2022 years using structured questionnaires for male and female office workers working in university education administration organizations. The SPSS 23.0 and AMOS 23.0 programs were used for data processing, and the structural model and control effect were analyzed through the Structural Equation Model (SEM).
Results The results of this study are as follows. In the case of Research Hypothesis I, the hierarchical orientation of I-1 influenced safety behavior, the innovation orientation of I-2 influenced safety behavior, and the task orientation of I-4 influenced safety behavior the most among the sub-factors of organizational culture, but the relationship orientation did not affect safety behavior. In addition, in the case of Research Hypothesis II, the innovation orientation of II-2 influenced organizational performance, the relationship orientation of II-3 influenced organizational performance, and the task orientation of II-4 influenced organizational performance, but the hierarchical orientation did not affect organizational performance. In addition, in the case of Research Hypothesis III, it was found that safety behavior had an effect on organizational performance. In the case of the research hypothesis, there was a significant difference in the path coefficient between groups between four sub-factors of organizational culture according to work experience, safety behavior, and organizational performance in some routes.
Conclusions In conclusion, affirming innovation, relationship, and task-oriented culture among organizational cultures implies that university education administrative agencies need policy and institutional considerations to form innovation, relationship, and task-oriented culture for members.
Analysis of lifelong education media articles examined through text mining and topic modeling(2018~2022)
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Eun-Taek , Oh Heejung
Published: February 2023

Objectives This study examined the trends of media articles on lifelong education during the 4th Master Plan for Lifelong Education Promotion to find out what kind of discourse domestic lifelong education actually forms in the field. To this end.
Methods To this end, 232 articles were collected and analyzed using Big Kines, a news big data analysis system. Textom was used for data analysis, and text mining and topic modeling were performed.
Results As a result of topic modeling analysis, a total of five topics were derived: ‘Lifelong education in universities’, ‘Community lifelong education for the Disabled’, ‘To prepare for middle-aged retirement and expand opportunities to supplement the educational background of old age, ‘Innovation in the way of lifelong education’, and ‘Systematic management of lifelong education’.
Conclusions when analyzing media articles and looking at the contents of articles excluded from the study, lifelong education or lifelong learning tended to be simply used as a good modifier for policies or projects. Recognizing lifelong education as a positive image is a good phenomenon, but reckless misuse should be wary in order for the nature and value of lifelong education to spread correctly in the future. It also suggested the necessity of lifelong education policies and projects for young people in the future.
Development and effect of design thinking-based simulation practice program
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park Meera , Je Nam-Joo , Lee Do-Young
Published: February 2023

Objectives The purpose of this study was to verify the effect on empathy, creative disposition, problem-solving ability, and caring efficacy by developing and applying a design thinking-based simulation program for graduate-grade nursing students taking simulation practice courses.
Methods This study was a one-group time-series pretest-posttest design study to develop a simulation program applying the design thinking teaching method, a student participatory class, and to prove the effect of the developed program. This study was conducted for 15 weeks with 41 4th-year nursing college students at C University located in G city. The difference was confirmed through self-report questionnaire before and after class, and the effectiveness was verified using IBM SPSS 25.0 program. Hypothesis verification was analyzed using Repeated Measure ANOVA, Friedman test, and Wilcoxon signed-rank test.
Results There was no significant difference in the degree of empathy of the study subjects after simulation practice with the design thinking class model applied (F=0.66, p=.521), but there were significant differences in score changes in creative disposition (x2=11.63, p=.003), problem-solving ability (F=5.77, p=.006), and caring efficacy (F=3.18, p=.047). Enhancement of creativity and problem-solving ability are expected when applying design thinking to simulated practices. This in turn will increase care efficacy in the care process and ultimately result in qualitative improvement of nursing.
Conclusions Through the results of the study, it was possible to confirm the effects and characteristics of the nursing practice education program to which the design thinking-based simulation practice program was applied. Based on this, it is expected that it will improve practical job performance ability by using it for education such as knowledge and skills required in the field in the future, and will have a positive impact on field adaptability and nursing students' nursing practice education.
An Analysis on the Excellence Course in KMOOC: Based on Educational Scalability Analysis Instrument
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park JongHyang , An Hwasil
Published: February 2023

Objectives The purpose of this study is to analyze design component and an aspect of interaction for verifying how it was designed and managed in K-MOOC excellence courses, which need not additional time investment and endeavor of faculty in spite of a large-scale.
Methods 10 excellence courses in the casebook published in 2022 by National Institute for Lifelong Education were analyzed an aspect and level of interaction with ESAI and drawn common element in design among lectures during course period. We analyzed two dimensions, which stand for design and interaction: one from the side of course design is implemented character including learning week, the length of video and the other one, which is related to learning activity, is interaction’s type such as T-S, S-S, C-S and feed-back level of them.
Results The result of this study shows that 8 out of 10 lectures consisted of 15 weeks like one semester in university as common design component, and modules and units with variable subtopic followed each week learning content. Learning activities were mainly video, quiz, discussion and homework, a running time of video is around 10-30 min. Interactions like S-C, S-T, S-S were executed evenly among the lectures and the level of feedback was simply responded to learner’s activity.
Conclusions K-MOOC course components such as course segmented content, various learning activities, and S-C interaction should be prepared at the phase of course design, not the phase of running course. Also both design element and the strategy of interaction in 10 excellence lectures presented difference from general online course, therefore it needs to be developed more effective and efficient strategy to conjugate K-MOOC.
Effects of Aging Simulation Activity on College Students’ Perception of Physical Changes in Older Adulthood
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jeong Yu-Jin
Published: February 2023

Objectives The purposes of this study were to develop an aging simulation activity as a part of gerontology class and to examine its effects on college students’ perception of physical changes in older adulthood.
Methods The participants were 14 students who signed up for a gerontology class during fall semester in 2022 at J university. They participated in the aging simulation activity. Before and after the participation, the students completed a questionnaire composed of five questions. At the end of the activity, they were also asked to list three words associated with their experiences. The data were analyzed by Wilcoxon signed rank test and content analysis.
Results After doing the aging simulation activity, the participants perceived the effects of aging-related physical changes on the elderly more seriously. They described aging-related physical changes with the word of ‘frustrated’ and ‘hard.’ The analysis of the meanings of free association words contained 19 sub-themes, and they were categorized into three themes: ‘experience of physical functioning limitations or decline,’ ‘chargers accompanying the physical functioning limitations or decline,’ and ‘empathetic understanding of the elderly and the realization of needs of behavioral chargers for older adults.’
Conclusions Aging simulation activity is effective in that it helps college students experience physical, psychological and emotional, social, and behavioral chargers with aging in older adulthood and understand the elderly in the empathetic way, and realize the needs of behavioral changes. These results reflect that the aging simulation activity proposed in this study would be an effective teaching method in operating gerontology-related classes. Based on the limitations, the directions for future research and aging simulation activity programs are suggested.
Effect of bypass fat on milk lipid quality and reproductive efficiency of dairy cows
Authors: Ramos Lesvy , Apraez Jose Edmundo , David Diana Milena , Navia Jorge Fernando
Published: February 2023

Nariño (Colombia) has high dairy potential; however, their herds present difficulties in the nutritional component (energy imbalance) of the cows, affecting their productivity. This research evaluated the effect of a bypass fat supplement on lipid concentration in milk and the reproductive efficiency of dairy cows. The study was based on 21 Holstein x Simmental cows between first and third calving and the following was supplied: forage + concentrate (T1); forage + concentrate + 250 g/day of bypass fat (T2) and forage + concentrate + 250 g/day of bypass fat enriched with omega-three (T3). The experiment was conducted from day 15 pre-calving until day 105 of lactation. During this period, milk quantity, quality, composition, and reproductive behavior were recorded. For data analysis, a repeated measure mixed design with time-series data was used, where the fixed effects were the treatments, periods, and their interaction, the animals represented the random effect, and the covariable was the estimated milk yield during lactation. The results showed normal mobilization of adipose tissue; the compositional quality of the milk did not vary across treatments, although T2 presented a higher estimated production per lactation, and T3 presented a higher percentage of fatty acid C18:2. In the reproductive indicators, they were not influenced between the treatments; concluding that the base diet offered in the herd presents a nutritional balance appropriate to the requirements of the cows in production.
Correlative analysis of climate impacts in an Andean municipality of Colombia
Authors: Ortega Luis Carlos , Cañón Julio Eduardo
Published: February 2023

The municipality of Pasto (Colombia) is an intermediate, emerging city of the Colombian Andes, which is vulnerable to the impacts of climate change due to its environmental conditions, mountainous morphology, moderately humid climate, and socio-economic structure. This research aims at identifying the impacts of historical trends in climate variables on the main urban elements of the municipality of Pasto. The study uses the correlational method to determine the relationships between climate variables and some impacted urban elements between 2004 and 2019. The adjusted models allow identifying possible trajectories in the evolution of urban variables affected by climate change, population growth, and culture. Results show that climate variability produces negative quadratic trajectories in crop yields and flood events; positive quadratic patterns in landslides, forest fires, the prevalence of acute diarrheal diseases (ADD), and acute respiratory infections (ARI); and linear patterns in water availability, livestock production and food security. In general, the urban variables show a departure from equilibrium when exposed to higher temperatures and precipitation, which affect the reliability of crop yields, food security, water availability, natural disasters, and public health in the municipality of Pasto.
Bio regulation of Meloidogyne incognita (Kofoid & White) Chitwood and M. javanica (Treub) Chitwood complex in coffee roots
Authors: Castro-Toro Angela Maria , Rivillas-Osorio Carlos Alberto
Published: February 2023

The Meloidogyne incognita and M. javanica complex cause damage to the coffee plants’ roots with loss of productive potential. Traditional management against this complex is based on the use of chemical molecules which causes problems in soil health and harmful to the environment. In this regard, the Micosplag® biotechnological input [Paecilomyces lilacinus (Thom) Samson, 1974, Metarhizium anisopliae (Metsch) Sorokin and Beauveria bassiana (Balsamo) Vuillemin] and Tricho-D® (Trichoderma harzianum Rifai, 1969) were evaluated under greenhouse conditions against root-knot nematode complex. A dose of 2g. L-1 of water was used for Micosplag® and 10g. L-1 of water for Tricho-D®, applying a volume of 20mL.1 per plant. The nematode inoculation was carried out eight days after the sowing, using 2500 eggs per plant. Bioinputs were applied preventively and also as bioregulators of an existing nematodes population. Nine treatments, which corresponded to different moments of application of bioinputs in soil and soil plus vermocompost were evaluated. Results showed the lowest levels of infection when the Micosplag® bioinput was applied preventively (infection level of 6%), followed by the Tricho-D® treatment (infection 12%). There were statistical differences with the controls which were inoculated alone with the nematodes. When the two Bioinputs were applied preventively, they offered greater protection to the roots against nematodes. Dry weights of root and the aerial part of the plants showed the lowest values in treatments where the nematode was inoculated. Six months after the experiment was established, the three fungi that compose the Micosplag® Bioinput were isolated from the rhizosphere of the coffee plants.