bluuebunny/crossref_metadata_2025 huggingface dataset:
STATE PENSION PROVISION, SOCIO-ECONOMIC DEVELOPMENT OF SOCIETY IN UKRAINE
Authors:   KROK University, Грушко Віктор , Кузьмінський Володимир ,   KROK University, Герасименко Мирослава ,   KROK University
Published: January 2024

Стаття присвячена державному пенсійному фонду України, що має значущий вплив на соціально-економічний розвиток українського суспільства і є надзвичайно актуальною, оскільки вона безпосередньо впливає на добробут громадян, демографічну ситуацію, працездатність населення та фінансову стійкість країни. Обґрунтовано впровадження політики підвищення пенсійного віку. Україна стикається з проблемою старіння населення та зменшення кількості населення через високий рівень смертності та низький рівень народжуваності. Ця демографічна ситуація впливає на фінансове навантаження пенсійного фонду, оскільки зменшення робочої популяції і збільшення пенсійного віку можуть призвести до дефіциту у пенсійній системі. Використано системний підхід для дослідження теоретичних підходів щодо визначення ролі та значення пенсійного забезпечення. Значна увага приділена аналізу сучасного стану пенсійних фондів. За допомогою методу системного аналізу оцінено забезпечення фінансової стійкості пенсійного фонду, що є критично важливим для забезпечення виплат пенсій та соціальних виплат. Питання структуризації фонду та забезпечення його сталого фінансування вимагає постійної уваги. Політика пенсійного фонду також повинна бути справедливою і враховувати інтереси різних верств населення. Важливо забезпечити, щоб пенсійні виплати відповідали рівню інфляції та життєвим витратам громадян. Пенсійна система також може вплинути на розвиток економіки. Якщо пенсіонери мають високий рівень доходу, це може сприяти споживанню та підтримці економіки. З іншого боку, велика частка бюджету, спрямована на пенсії, може обмежити можливості держави інвестувати в інфраструктуру та соціальні програми для молоді. Запропоновано заходи щодо забезпечення фінансової стійкості пенсійної системи, справедливості та врахування демографічних викликів, щоб підвищити добробут і соціальний захист для всіх громадян.
NON-GOVERNMENTAL THINK TANKS OF UKRAINE: MODERN ASPECTS OF DEVELOPMENT AND MANAGEMENT
Authors:   KROK University, Львова Ольга , Ляшенко Олександра ,   KROK University
Published: January 2024

У статті розглянуто еволюцію неурядових аналітичних центрів України протягом останніх десятиліть. Визначено роль даних організацій у трансформаційних процесах, які відбувалися в Україні, та їхню важливу функцію у формуванні публічної політики. Прослідковано еволюцію діяльності аналітичних центрів після проголошення незалежності України та поступовий їх перехід від опозиційної ролі до партнерів держави після подій Євромайдану. Основними викликами, як стали ключовими перешкодами для ефективної роботи аналітичних центрів, є: проблеми фінансування, кадрові питання та комунікаційні розриви. Виявлено нові проблеми, з якими зіштовхнулися аналітичні центри після повномасштабного російського вторгнення, зокрема безпекові виклики, фізичне та емоційне виснаження, збереження команди. Автори показують, що попри всі труднощі неурядові аналітичні центри вносили суттєвий вклад в демократичні процеси в Україні і прогнозують, що важливість аналітичних центрів зростатиме. Метою статті є визначення деяких особливостей розвитку та управління неурядовими аналітичними центрами в цілому та в умовах війни зокрема. Дослідження використовує методи аналізу етапів розвитку аналітичних центрів, визначення викликів, з якими вони стикалися та аналізу сильних та слабких сторін їхньої діяльності. Отримані результати підкреслюють зміни ролі аналітичних центрів від опозиційних до партнерських після Євромайдану та їхню активну участь у протистоянні російській агресії. Дослідження визначає ключові аспекти, які визначають успішність діяльності неурядових аналітичних центрів, а також їхню роль у підтримці демократичного курсу та розвитку України. Зазначається, що аналіз цих процесів є важливим як для самих організацій, так і для всіх зацікавлених сторін у політичному та науковому співтоваристві. Перспективи подальших досліджень – внесок українських аналітичних центрів в два ключові напрями - європейська та євроатлантична інтеграція та відновлення країни.
PENGARUH BAURAN PEMASARAN (MARKETING MIX) TERHADAP MINAT BELI ULANG MIXUE KOTA SEMARANG
Authors: Aditama Yogi Sofiyan Chaesa , Amron Amron
Published: January 2024

Penelitian ini bertujuan untuk menguji pengaruh produk, harga, promosi dan tempat terhadap minat beli ulang di Mixue Kota Semarang. Mempergunakan medote kuantitatif dengan tujuan guna melihat pengaruh produk, harga, promosi serta tempat terhadap minat beli ulang. Data primer penelitian ini berasal dari penyebaran survei Google Form. Konsumen yang pernah membeli Mixue di Kota Semarang dijadikan sebagai populasi. Purposive sampling yang digunakan untuk pengambilan sampel non-probably sesuai dengan kriteria yang sudah ditetapkan. Responden dalam penelitian ini berjumlah 200 orang, merupakan konsumen Mixue di Kota Semarang, berusia sedikitnya 17 tahun dan telah melakukan sekitar tiga kali pembelian Mixue. Data yang di olah mempergunakan aplikasi SPSS 25 dengan metode analisis berganda. Temuan penelitian menjelaskan bahwasanya minat beli ulang Mixue dipengaruhi secara positif dan signifikan oleh  produk, harga, promosi serta tempat.
INTELLECTUAL CAPITAL AND FINANCIAL PERFORMANCE ON BANKING FIRMS IN INDONESIA
Authors: Tang Sukiantono
Published: January 2024

With the rapid advancement of global economic progress, lot of innovation has been made and attract researchers to investigate Intellectual Capital (IC). The purpose of this paper is to find any relationship Intellectual Capital toward Financial Performance. Using Value Added Intellectual Coefficient (VAIC) Model and the modified version as the research model. This study takes secondary data from companies that published its annual financial statement in Indonesia Stock Exchange during 2017 until 2022. The gathered data then analysed by using regression panel method. This research shows that Human capital doesn’t significantly affect ROA and ROE but does significantly affect ATO in both VAIC model and Modified VAIC model. Structural capital also insignificantly affects ROE and ROE but significantly affect ATO when tested using VAIC model. Capital employed and innovation capital is proven to a positive significant effect to all dependent variables.
Evaluation of lesions requesting biopsy according to imaging findings in breast cancer patients who have undergone breast-conserving surgery
Authors: Torun Ebru , Arda Kemal , Coşar Zehra Sumru
Published: January 2024

Aims: In patients undergoing breast-conserving surgery (BCS), the traditional follow-up imaging methods of the breast are mammography and ultrasonography. However, after BCS and radiotherapy, it becomes more difficult with imaging methods to detect the presence of recurrence or secondary focus due to the change of normal breast structure in patients. In this study, we aimed to investigate the sensitivity, specificity and malignancy prediction values of imaging methods in the follow-up of patients who underwent BCS.
Methods: 421 patients diagnosed with breast cancer who underwent BCS were retrospectively analyzed. 63 patients with histopathology results, which were categorized as BI-RADS 4 or 5 according to imaging findings in their follow-up after BCS, were included in the study. The age of diagnosis, time taken for biopsy and mammography, ultrasonography and magnetic resonance imaging findings were recorded. Patients were divided into 2 groups (benign and malignant) according to the results of biopsy. According to the pathology results, sensitivity, specificity, positive and negative predictive values and diagnostic accuracy levels of radiological imaging findings were calculated. The significance of the difference between pathology groups in terms of mean age of diagnosis and biopsy time was evaluated by Mann-Whitney U test. Categorical variables were assessed by Yates test or Fisher's exact test.
Results: Of the 63 patients, 49 (77.7%) were benign and 14 (23.3%) were malignant. There was a significant difference between the two groups in mass finding on mammography and posterior acoustic shadowing on US (p=0.011, p=0.049, respectively).
Conclusion: MRI is the most sensitive imaging method in post-BCS follow-up and mammography is the most specificity imaging method. The finding with the highest positive predictive value for malignancy detection is the presence of mass on mammography and posterior acoustic shadow on ultrasonography.
Exploring normal urinary biomarker ratios in a pediatric population: insights into age and gender variations
Authors: Gülyüz Abdulgani
Published: January 2024

Aims: The assessment of urinary biomarker ratios, such as sodium/creatinine (Na/Crea), potasium/creatinine (K/Crea), calcium/creatinine (Ca/Crea), phosphorus/creatinine (P/Crea), uric acid/creatinine (Uric acid/Crea), magnesium/creatinine (Mg/Crea), and sodium/potassium (Na/K), holds significant importance in clinical and research contexts as they offer insights into physiological and pathological processes. This study aimed to establish the normal ranges of urinarymineral ratios across age and gender groups in a Turkish pediatric cohort.
Methods: This cross-sectional study was conducted involving 162 healthy children, with ages ranging from 2 to 15 years, at the Department of Pediatrics, Selçuk University. Demographic information, urinary biomarker ratios, and dietary features were recorded. Participants were divided into three age groups (2-5, 6-10, and 11-15 years), and statistical analyses were performed to determine relationships and variations.
Results: Gender distribution was uniform across age groups (p>0.05). Urinary creatinine levels stabilized after age 6. The mean urinary Na/Crea ratio was 0.33±0.22 mEq/mg, showing correlations with age and other ratios (p<0.001). Urinary K/Crea ratio was 0.13±0.15 mEq/mg, with significant differences between Group 1 and Group 3 (p>0.05). Urinary Na/K ratio was 3.5±2.4 mEq/mEq and correlated with uric acid and Ca/Crea ratio (p<0.001). Urinary calcium levels were consistent (p<0.001). Ca/Crea ratio correlated with other ratios (p<0.001). Urine P/Crea ratio differed significantly among groups (p>0.05). Uric acid levels differed between Group 2 and Group 3 (p>0.05), while uric acid//Crea ratio correlated with age and other ratios (p<0.001).
Conclusion: The findings provide insights into the normal ranges of urinary biomarker ratios in a Turkish pediatric cohort. The results align with previous studies and emphasize the impact of age, gender, and dietary factors on these ratios.
Evaluation of artificial neural network and adaptive-network-based fuzzy inference system for ovarian and lung cancer prediction
Authors: İpek Semih Latif , Göktürk Dilek
Published: January 2024

Aims: Every year, a significant number of individuals lose their lives due to cancer or undergo challenging treatments. Indeed, the development of an effective cancer prediction method holds great importance in the field of healthcare.
Methods: Machine learning methods have played a significant role in advancing cancer prediction models. In this context, this study focuses on exploring the potential of two machine learning methods: Artificial neural network (ANN) and adaptive-network-based fuzzy inference system (ANFIS) for cancer prediction. In this study, two different types of cancer, ovarian cancer and lung cancer, are taken into consideration. For the prediction of ovarian cancer, three specific biomarkers, namely human epididymis protein 4 (HE4), carbohydrate antigen 125 (CA-125), and carcinoembryonic antigen (CEA), are used to develop a prediction model. For the prediction of lung cancer, six different variables are utilized in the development of both the ANN and ANFIS methods.
Results: The findings demonstrated that the proposed methods had an accuracy rate of at least 93.9% in predicting ovarian cancer. With an accuracy rate of at least 89%, the proposed methods predicted lung cancer. Also, the proposed ANN method outperforms the ANFIS method in terms of predictive accuracy for both ovarian cancer and lung cancer.
Conclusion: This study suggests that the ANN method provides more reliable and accurate predictions for these specific cancer types based on the chosen variables or biomarkers. This study highlights the potential of machine learning methods, particularly ANN, in improving cancer prediction models and aiding in the early detection and effective management of ovarian and lung cancers.
Predictive value of cervical length in placenta previa totalis: a single-center experience
Authors: Kahramanoğlu Özge , Öcal Aydın
Published: January 2024

Aims: In our study, we aimed to scientifically assess the utility of measuring cervical length in predicting the risk of postpartum hemorrhage and the necessity for emergency preterm cesarean delivery in women diagnosed with placenta previa totalis.
Methods: We conducted a retrospective study at a single medical center, comprising 48 pregnant women diagnosed with placenta previa totalis. Cervical length was precisely measured through transvaginal ultrasound. Patients were categorized based on cervical length (CL): CL >30mm, CL 25-30 mm, and CL <25 mm. Primary outcomes included preterm birth, postpartum hemorrhage, and emergency cesarean section.
Results: Women with CL <25 mm exhibited a notably elevated risk of postpartum hemorrhage (60%) and emergency cesarean section (80%). While preterm birth rates displayed variations among groups, statistical significance remained elusive. APGAR scores demonstrated consistency across cervical length categories.
Conclusion: Evaluation of cervical length holds promise as a valuable tool in the comprehensive management of placenta previa totalis. Women presenting with a cervical length less than 25 mm may warrant intensified monitoring and targeted interventions to mitigate adverse perinatal outcomes. Further research endeavors are imperative to corroborate these findings and advance the care provided for these intricate pregnancies.
Bibliometric analysis of publications on kinesiophobia in orthopedics between 1970 - 2023
Authors: Kurt Mehmet
Published: January 2024

Aims: This bibliometric study aimed to examine the hotspots and frontiers of kinesiophobia research in orthopedics and to assess the overall scientific output of the field.
Methods: The Web of Science Core Collection was mined for articles on kinesiophobia that were published between 1970 and September 2023. Using common bibliometric indicators, Vosviewer was used to examine the number of publications, countries, institutions, journals, authors, cited references, and keywords.
Results: The results of a bibliometric analysis focused on the body of knowledge on kinesiophobia. The study analyzed 2,035 articles from 75 different countries and identified important trends and groundbreaking research. In particular, there has been a steady increase in recent years, with publications increasing significantly between 2001 and 2012. The highest contribution came from the United States and the most cited articles addressed clinical recommendations for low back pain. Both the Florida State University System and the University of Florida made significant contributions. With a total of 51,443 citations, this study provides a comprehensive overview to help guide future research in orthopaedics and related fields.
Conclusion: The results of this bibliometric study give an overview of the state and trends in clinical research on kinesiophobia and may be used by researchers to pinpoint hot themes and consider fresh lines of inquiry.
Can a unilateral approach replace the bilateral approach in percutaneous kyphoplasty?
Authors: Taşkala Baran , Sucu Hasan Kamil , Sevin Ertan , Cıkla Ulaş
Published: January 2024

Aims: The main techniques used in balloon kyphoplasty include bilateral and unilateral approaches, but debate continues regarding their effectiveness. This study primarily aims to evaluate the clinical effects and safety profiles of unilateral and bilateral balloon kyphoplasty in osteoporotic and traumatic vertebral compression fractures and to compare patient satisfaction. The study's secondary aim is to identify the factors affecting prognosis, if any, in the general patient population. Our study compared the clinical and radiological results of patients with thoracolumbar vertebra fractures who underwent bilateral and unilateral balloon kyphoplasty operations in general and separately for patient subgroups.
Methods: Patients who underwent balloon kyphoplasty at the Neurosurgery Department of Atatürk Training and Research Hospital were investigated retrospectively and called for outpatient clinic control. Their current condition and satisfaction were evaluated. Clinically, patient satisfaction was assessed using a three-point Likert scale, Roland-Morris Disability Questionnaire, and VAS (Visual Analog Scale), and radiologically, preoperative, early postoperative, and late postoperative images in the sagittal plane, vertebral kyphosis angle, segmental kyphosis angle, Beck index, height loss, and axial canal compressions were examined and evaluated comparatively.
Results: A total of 77 patients who could be contacted and who were able to access the outpatient clinic were included in the study. Sixty-seven of the patients underwent unilateral surgery, and ten patients underwent bilateral surgery. In the final control, patients who underwent bilateral kyphoplasty had less height loss than patients who underwent unilateral kyphoplasty. There was no difference in other radiological outcomes. There was no significant difference in clinical outcomes between patients who underwent bilateral and unilateral kyphoplasty. Mean Visual Analogue Scale and Roland Morris scores at the final follow-up were significantly higher in female patients than in male patients.
Conclusion: There was no statistically significant difference in the satisfaction of patients who underwent bilateral kyphoplasty compared to unilateral kyphoplasty. This result may be due to the small number of patients in the study, and more extensive series are needed. The fact that the clinical results of female patients are worse than those of male patients may be a guide to giving realistic answers to the questions of patients' prognosis and pain expectations in the postoperative period.
Comparison of early warning and sepsis scores for mortality prediction in patients with suspected infection admitted to medical intensive care units
Authors: Başpınar Batuhan , Erdat Efe Cem , Ersoy Ortaç Ebru , Topeli Arzu
Published: January 2024

Aims: To compare the mortality prediction efficiency of the Modified Early Warning Score (MEWS), Systemic Inflammatory Response Syndrome (SIRS), Sepsis Related Organ Failure Assessment (SOFA), and Quick Sepsis Related Organ Failure Assessment (qSOFA) calculated within 48 hours before ICU admission.
Methods: A prospective, noninterventional, observational cohort study enrolled adult patients admitted to medical intensive care units (ICU) with suspected infection in a tertiary care medical center. MEWS SIRS, SOFA, and qSOFA scores were calculated at four different time points: 48, 24, and 8 hours before and at the time of the ICU admission (0. hour). The scores were analyzed for hospital mortality.
Results: A total of 120 patients were included. The median age was 68 (IQR 59.8-79) years, and 44.2% of patients were male. Of the study population, 75.8% were admitted to the medical ICU from the emergency department, while the remaining were from the medical wards. Considering the scores observed 48 hours before ICU admission, Odds Ratio (OR) of SIRS≥2 and SOFA≥2 showed a value of 7.6 (95% CI: 1.5-38.0) and 13.2 (95% CI: 2.3-74.3), respectively, while no increase in risk was observed for MEWS and the qSOFA score. Receiver operating characteristic analysis (ROC) performed with the highest scores observed at any time within 48 hours before ICU admission (ICU admission values were omitted) regarding hospital mortality yielded area under the curve (AUC) values (95% CI) of 0.80 (0.72-0.89) for SOFA, 0.66 (0.54-0.76) for MEWS, 0.63 (0.51-0.74) for qSOFA, and 0.61 (0.49-0.73) for SIRS. SOFA had the highest sensitivity of 92.6% (82.7-100.0), whereas qSOFA had the highest specificity of 63.0% (49.1-77.0) for hospital mortality.
Conclusion: SOFA score is the most sensitive scoring system to predict hospital mortality in patients admitted to the medical ICU with suspected infection compared to MEWS, SIRS, and qSOFA. Nevertheless, the sepsis and early warning scores should be combined in clinical practice whenever possible.
The role of preoperative serum CA-125 levels in predicting lymph node metastasis in patients undergoing treatment for endometrial cancer
Authors: Özdemir Savaş , Şahin Fatih , Doğan Ozan , Kinter Alp Koray , Akbayir Özgür
Published: January 2024

Aims: Endometrial cancer stands as the most prevalent gynecological malignancy in developed nations, often detected at an early stage, and generally carries a positive prognosis. The stage of the disease is important for survival, but many factors such as tumor grade, histopathology, myometrial invasion, age, and spread are also effective. Our objective was to assess the significance of preoperative Cancer antigen 125 (CA-125) concentrations in the prediction of lymph node metastasis in patients with endometrial cancer and to identify a suitable threshold value.
Methods: This retrospective analysis was carried out on 286 female patients diagnosed with endometrial cancer at a specialized gynecologic oncology facility from 2012 to 2022. We examined clinical-pathological and demographic attributes, including preoperative serum CA-125 concentrations, surgical interventions conducted for each patient, post-treatment physical assessments, imaging findings, and cytological outcomes. CA-125 was measured using electrochemiluminescence immunoassay.
Results: Statistically significant differences were observed in CA-125 levels among patients in terms of grade, invasion depth, lymph node involvement, cervical involvement, and stage (respectively, p<0.001, p=0.042, p<0.001, p<0.001, p<0.001). The FIGO advanced stage ratio was 30.6 times higher for serum CA-125 concentrations above the cutoff of 21 IU/ml (95% CI: 10.7-87.6) (p<0.001). Lymph node involvement was 29.7 times more likely for serum CA-125 values above the cutoff of 35 IU/ml (95% CI: 25.3-74.8) (p<0.001).
Conclusion: Early identification of high-risk endometrial cancer patients is vital for prognosis and guiding adjuvant therapy. CA-125, a tumor marker, has been found useful in assessing myometrial invasion depth, lymph node involvement, stage differentiation, and tumor grade.
Variant analysis of MiRNA regulatory genes in colorectal cancer
Authors: Bağcı Özkan , Marzioğlu-özdemir Ebru , Şanlıtürk Batuhan
Published: January 2024

Aims: The aim of this study was to investigate the clinical significance of mutations in AGO2, DICER and DROSHA genes, which are involved in miRNA biogenesis, as well as TP53, KRAS, BRAF, PI3KCA and APC genes, which are important in the pathophysiology of CRC, and their association with metastasis in patients diagnosed with sporadic colorectal cancer
Methods: DNA isolation was performed by taking 10-micron sections from paraffin-embedded tissue samples of 12 patients diagnosed with CRC and Kapa NGS DNA extraction kit was used for sequence analysis. The purity and concentration of the DNA obtained was measured by Qubit fluoremeter, and NadPrep DNA Universal Library Preparation Kit was used for high quality library preparation. Bioinformatics analyses were performed on the Genomize Seq platform.
Results: In our study, metastasis was detected in 42% of 12 colorectal cancer patients. Mutations in at least two miRNA biogenesis genes were detected in 80% of metastatic patients. In addition, variants detected in miRNA biogenesis regulatory genes and oncogenic genes were summarized according to pathogenicity status according to the American College of Medical Genetics and Genomics (ACMG) classification.
Conclusion: Genes involved in miRNA biogenesis and mutations of clinically relevant genes in CRC have important implications on disease prognosis and response to therapy. Mutations in these genes may be associated with the development of metastases and mechanisms of resistance to treatment and may be potential genetic markers for the development of personalized treatment strategies.
Distribution of ABO and Rh blood groups in gynecological cancer cases
Authors: Adan Ramazan , Mihmanlı Veli
Published: January 2024

Aims: To investigate the relationship between blood type and gynecological cancers (ovarian, endometrial, and cervical).
Methods: In the study, between 2017 and 2022, 457 patient files who underwent surgery for gynecological cancer at İstanbul Prof. Dr. Cemil Taşçıoğlu City Hospital were reviewed. Seventy-eight of these files were excluded from the study due to missing data. Out of the remaining files, 379 were considered suitable for the study. Twenty-five of these were further excluded due to being cases of other gynecological cancers. A total of 354 patients were included in the study (n=354). Participants' sociodemographic data such as age and gender, cancer type, and blood groups (ABO-Rh) were retrospectively collected from patient records and the hospital automation system. Cases with missing data or inaccessible sociodemographic records were excluded from the study. The study was planned retrospectively and observationally. Gynecological cancers were examined in the three most common groups: ovarian cancer, endometrial cancer, and cervical cancer. The patients' blood group, Rh status, and pathology reports were analyzed. Based on the pathological diagnosis, three groups were initially formed, and below them, Rh and blood group status were noted. The blood group and Rh status in cancer groups were first presented in numbers and then calculated as percentages.
Results: The AB+ ratio in cervical cancers was statistically significantly higher compared to the reference article and endometrial cancers (p=0.021, p=0.049).
Conclusion: There are studies indicating a significant relationship between blood groups and various diseases. The expression of blood group antigens on blood cells and other epithelial surfaces acting as receptors or signal transducers contributes to these findings. The possibility of ABO antigens serving as receptors in tumor structures caused by infections, such as cervical cancer, should not be overlooked. In this regard, the significantly higher prevalence of cervical cancer in individuals with AB Rh (+) blood type, carrying A, B, and Rh antigens, can be explained concerning the population.
A Comparative Study on Sexual Function and Sexual Distress of Women With and Without Breast Cancer in Zanjan, Iran
Authors:   Department of Heath, School of Medicine and Dentistry, Griffith University, Gold Coast, QLD, Australia., Esmkhani Mina , Youseflu Samaneh ,   Departmant of Nursing and Midwifery, Faculty of Nursing and Mdiwifery, Reproductive Health, Medical Science University, Esfahan, Iran., Hosseinzadeh Mohsen ,   Department of Pscychometry, Allameh Tabataba'i University, Tehran, Iran., Nezhad-Fard Monireh Moharram ,   Department of Midwifery, Faculty of Nursing and Mdiwifery, Medical Sciences University, Zanjan, Iran., Ghanbarpour Fateme ,   Department of Psychology, Faculty of Heath, Babol University, Babol, Iran., Merghati Khoei Effat ,   Department of Sexology, Medical Science University, Tehran, Iran.
Published: January 2024

Background & Aims Breast cancer (BC) is one of the important challenges of the health system due to its impact on marital relationships. This study aims to compare sexual function and sexual distress of women with and without BC. Materials & Methods In this case-control study, 75 women with BC and 75 healthy women from Zanjan, Iran participated. Data were collected using a demographic form, the female sexual distress scale-revised (FSDS-R), and the female sexual function index (FSFI). Data analysis was done in SPSS software, version 20 using the Mann-Whitney test and multivariate analysis of covariance. Results The mean age of patients was 36.49±6.53 years and the mean age of controls was 36±0.72 years. There was no statistically significant difference between the two groups in terms of some demographic variables such as age, educational level of women and their husbands, occupation of women and their husbands, place of residence, and number of children (P>0.05). The mean score of FSFI in all subscales in the patient group was lower than in the control group. This difference was statistically significant only in the dimension of desire (P=0.003). regarding the sexual distress variable, the mean FSDS-R score of healthy women was lower than that of women with breast cancer, but this difference was not statistically significant (P>0.05). Conclusion The difference between women with and without breast cancer is significant only in the desire domain of sexual function. There is no statistically significant difference between the two groups in sexual distress and in other domains of sexual function. The sexual problems of women with BC require consideration and support, and provding counseling in terms of sexual function.
EPISTEMOLOGICAL DEVELOPMENT OF ADMINISTRATIVE-LEGAL PRINCIPLES IN RESEARCH ON LAW ENFORCEMENT AGENCIES
Authors: Sopilko Iryna , Tokarieva Kseniia
Published: January 2024

This research delves into the evolving epistemological foundations of administrative-legal principles within the domain of law enforcement agencies. A meticulous analysis of over 200 scholarly works, with a specific focus on more than ten dissertations, has been conducted to illuminate the essence and content of activities undertaken by law enforcement agencies. The study offers a comprehensive un-derstanding of administrative-legal principles, encompassing their functions, forms, methods of opera-tion, and their legal underpinnings as reflected in sectoral legislative acts. The investigation explores the concept of „administrativelegal principles” and establishes its intricate interrelations with key cate-gories in administrative law, such as „principles of administrative law,” „legal regulation,” and „admin-istrative-legal norms.” Findings reveal that administrative-legal principles form a cohesive system in-fluencing the functions, forms, and methods of operation employed by law enforcement agencies. Key outcomes of the study emphasize the paramount importance of delving into administrative-legal principles within the specific context of law enforcement agencies. A nuanced examination of their functions, forms, and methods of operation underscores their critical role. This research advocates for understanding administrative-legal principles as foundational elements of administrative law, shedding light on their pivotal function in regulating the multifaceted activities of law enforcement agencies.
PROTECTION OF CHILDREN’S RIGHTS DURING IMPLEMENTATION OF GUARANTEES IN EXECUTIVE PROCEEDINGS: THEORETICAL AND LEGAL STUDY
Authors: Stepanenko Natalya , Kubrak Danylo
Published: January 2024

The article delves into the theoretical and legal dimensions of safeguarding children’s rights within the framework of enforcement proceedings guarantees. It presents the guarantee system as comprising various elements, such as procedural oversight, appeals mechanisms against executor actions, measures for holding violators accountable, involvement of relevant professionals, and the normative regulation of rights and obligations for all participants. Through legislative analysis and practical examination, the article asserts that safeguarding children’s rights in enforcement proceedings unfolds in two primary facets: protection of property rights and protection of personal non-property rights. In the realm of property rights, emphasis is placed on securing child support payments from debtor parents to foster the child’s well-rounded development. Additionally, it addresses preventing the eviction of a minor from mortgaged housing in cases involving parents-mortgagors. For the protection of non-property rights, measures include child removal, establishment of visitation rights, and removal of obstacles to visitation. The article underscores the importance of sound reasoning and evidence when considering temporary child placement and ensures debtors receive copies of enforcement proceedings decisions during searches. It advocates for petitioning the court to amend or clarify visitation-related decisions. Special attention is given to the involvement of professionals such as doctors, teachers, and psychologists in enforcement proceedings to safeguard minors’ rights, ensuring their mental and physical well-being and preventing potential abuse by involved parties
E-COMMERCE IN UKRAINE: TAXATION CHALLENGES AND GLOBAL TRENDS
Authors: Lytvyn Nataliia A. , Boreyko Nataliia M. , Artemenko Olena V. , Subina Tatiana V. , Sliusarenko Serhii V.
Published: January 2024

The economic sector of Ukraine has experienced transformative shifts toward e-commerce. This prosperous sphere of the digital economy attracts much prominence among legislative bodies since its growth rates increase annually, making the issue of taxation urgent. The article is aimed at monitoring the status of e-commerce through the prism of the development and spread of e-commerce in the domestic segment of the Internet, the impact of e-commerce on the national economy, and also at developing proposals for improving certain aspects of the taxation of business entities in Ukraine with due regard for the positive international experience and minimising the risks of fraud in the sale of goods (services) on the Internet. The study employs a combination of general theoretical and economic-mathematical methods, which are fundamental to scientific inquiry. This article presents research findings related to several key aspects. First, it examines the development and proliferation of e-commerce within Ukraine. Second, it elucidates the impact of e-commerce on the national economy. Additionally, the article addresses pertinent issues regarding the taxation of entities engaged in e-commerce within contemporary contexts. Moreover, it delves into the complex problem of protecting e-commerce participants from online fraud. Finally, the article suggests measures that can positively affect the taxation framework governing e-commerce and minimize the associated risks of fraudulent activities within the online marketplace. The author provided general conclusions on legislative changes against the background of the development of online commerce, analysed the peculiarities of the development and functioning of e-commerce under martial law, and, based on data from other countries, formed a unified vision of further changes in this area. The materials presented in this article hold practical value for a diverse audience, including scholars and practitioners in the field of e-commerce, educators at higher education institutions, and stakeholders concerned with the continued development and regulation of e-commerce
UPDATE OF THEOLOGICAL AND METAPHYSICAL BASES OF THE DEVELOPMENT OF THE MODERN MODEL OF THE NATIONAL ECONOMIC SYSTEM
Authors:   Volodymyr Dahl East Ukrainian National University, Ovechkina Olena , Braslavets Oleksiy ,   National Academy of Management
Published: January 2024

The article examines the main models of modern domestic capitalism. It was determined that the most popular model is the model of socially oriented economy, which corresponds to the model of sustainable development, the models of catch-up and anticipatory innovative development. A matrix of models for recovery and further development of the domestic economy has been compiled. It is shown that the promising socially-oriented model of the economy, recognized by all researchers, branches out depending on the goals and relevance of individual social, ecological, economic, and institutional issues. It has been proven that in the modern period, the issues of institutional development of the existing clan-oligarchic model of domestic capitalism and the transition to a democratic-Christian model of the state are of primary importance.
Chemical and Nutritional Compositions of Hydroethanol Leave Extract of Mentha piperita
Authors: Said Said Sani , Dambazau Sabiu , Muhammad Abdu Abdullahi , Aliyu Mukhtar , Ahmad Ali , Auwal Idris
Published: January 2024

Mentha which is also famous as mint is a genus of plants fit in the Lamiaceae family. M. piperita well known as peppermint is widely cultivated worldwide and used for its medicinal values. The aim was to evaluate the chemical and nutritional compositions of hydroethanol leave extracts of M. Piperita. The proximate composition were determined according to the perspectives methods, while mineral elements were determined using EDTA method. The moisture content (80.5%), the ash content (60.2%), the level of fat content (95.0%), crude protein (65.8%) and carbohydrate content (94.5%). The result indicates higher content of fat, carbohydrate and moisture in the leaf of M. piperita and a moderate content of ash and protein. The most predominant mineral found was iron with a value of 2.26ppm, sodium (2.1mg/l), and potassium (1.02mg/l), other minerals were found in low values ranging from Zinc 0.5ppm, Cobalt (0.28ppm), manganese and chromium (0.22ppm) each, phosphorus (0.1mg/l), and cadmium 0.02ppm respectively. The Fourier Transform Infrared (FTIR) analysis of the crude extract showed that the compounds contain the functional groups like–CO, Nitro, -OH, and other compounds, while its Gas chromatography-Mass spectroscopy (GC-MS) analysis contains, fatty acids, carbohydrate and other compounds. In conclusion, M. Piperita can be an excellent source of nutrients and mineral.
Management of Giant Cell Tumor by Curettage and Bone graft in Weight Bearing Bone - A Study Done in CENTRAL MEDICAL COLLEGE.
Authors: Hamid Md Kawser , Hasan Md Mainul , Rahaman Md Arifur , Hoque Mohammad Emdadul , Patwary Md Safiqur Rahman , Rahman Minhazur
Published: January 2024

Background: Giant cell tumor of bone (GCT) has been characterized as benign but often locally aggressive neoplasm that commonly occurs in proximity to weight bearing bone. Management of giant cell tumor of bone by curettage and bone graft in weight bearing bone is an effective method. This prospective experimental study was conducted among the patients with histologically proved giant-cell tumor who were admitted in the Department of orthopedic surgery, Central Medical College Hospital over a period of 18 months from January 2018 to June 2020. A total of 12 consecutive patients with histologically proved giant-cell tumour were included in the study. Majority (55.6%) of patient was in 3rd decade and male female ratio was 1:1.3. More than one fourth (25%) of the patients had GCT in the lower end of right femur, 33.3% in lower end of left femur, 25% in upper end of tibia, 16.7% in lower end of tibia and all patients had painful gait and swelling. According to campanacci grading, Grade-2 was found in all patients, and giant cell tumor was found in all patients, as evaluated by pre-operative biopsy. Cosmetically near normal appearance was found in 88.9% and 88.9% were able to do normal daily work. According to Schatzker and Lamber (1979) criteria excellent outcome was found in 41.7%, good in 50%, fair in 8.3%. Surgery in the form of intralesional curettage and filling the cavity with bone graft resulted in excellent relief of pain, cosmetically near normal appearance and patients were able to do normal daily work.

Central Medical College Journal Vol 7 No 1 January 2023 Page: 7-12
Laser In Proctology
Authors: Mahmud Nasir Uddin
Published: January 2024

Abstract not available 

Central Medical College Journal Vol 7 No 1 January 2023 Page: 3
Assessment of Solid Waste Management Practices in Rural Bangladesh: A Case Study of Citizen Participation
Authors: Zaman A K M Tajkir Uz
Published: January 2024

Bangladesh's rural solid waste management (SWM) systems are still developing, and effective citizen participation is crucial for SWM success. This study highlights knowledge gaps, as the existing policies focus predominantly on urban areas.In this study, citizen participation, existing practices, and the community engagement of SWM were examined in the rural areas of Bangladesh. Primary data collected from 67 Bangladeshi respondents through questionnaires using a qualitative and quantitative mixed-methods study. The data were analyzed using descriptive statistics. This study found that Bangladeshi rural citizens participate in SWM "personally." Results showed that 41.9% of respondents often dump waste in pits or lowlands near their homes, and a general practice was to discard waste by digging a hole (54.8%) or burying it (41.9%). Household backyards (41.9%) and shallow terrain (48.4%) were used as dumping stations. Different indigenous systems and practices were observed in the rural areas due to the lack of formal SWM. Respondents mentioned that the informal sector recycles plastic, paper, glassware, etc., and a few citizens generate compost from organic waste. Citizens reported that they needed SWM training from rural local governments. Moreover, SWM efforts in rural Bangladesh did not involve citizen groups or associations. In conclusion, local governments can coordinate SWM policy by including citizens for a sustainable environment, and policymakers will have a scope to improve rural SWM in Bangladesh. Furthermore, this paper provides practical implications for researchers and policymakers on SWM in developing countries.
Vol. 10, No. 3, December 2023: 301-318
Midline and Flank Approaches for Spaying: A Comparative Study in Cats
Authors: Sarola Rani  , Rafi Ahmed  , Md Sabbir Hossain  , Mst Antora Akter  , Moinul Hasan  , Md Rafiqul Alam  , Rukhsana Amin Runa
Published: January 2024

The study was conducted to compare midline and flank approaches for spaying in cats. Cats were divided into two groups based on surgical approaches for spaying, Group A (Flank approach) and Group- B (Ventral midline approach). To evaluate the best approach for spaying, various parameters such as length of the surgical incision, the extent of haemorrhage, ease of location and exteriorization of ovaries and uterus, duration of surgery, postoperative complications, and time required for complete wound healing were recorded. In addition, the heart rate, respiration rate, and temperature were recorded before the operation and on different days after the operation. The physical parameters significantly (P<0.05) differed between the two groups. In both groups, the average length of skin incision was 2.8 cm. The average time of exteriorization of ovaries and uterus was higher in the ventral midline approach as compared with the flank approach. The average duration of surgery was (23.25±4.20) min in group A and 29·25±4.88 min in group B. The average wound healing time (days) was also higher in the ventral midline approach (16.50±1.26) compared to the flank approach (13.75±7.85). During Spaying in cats, the extent of haemorrhage was mild to moderate in the flank approach, whereas there was no haemorrage or sometimes less in the ventral midline approach. The post-operative complications were less in flank methods than in ventral midline approaches. It is concluded that spaying through the flank approach is superior to the ventral midline approach due to convenience, faster healing, rapid recovery, and fewer postoperative complications.
Vol. 10, No. 3, December 2023: 319-326
Association Between Body and Udder Measurement Traits and Milk Yield of Holstein Cows
Authors: Xichavo Invite Risimati  , Thlarihani Cynthia Makamu  , Thobela Louis Tyasi
Published: January 2024

The association between body and udder measurements can be used towards the improvement of milk yield. Hence, this study aimed to identify the udder measurement traits and body measurement traits that may be used by farmers to increase milk yield of Holstein cows. The study was conducted at Limpopo Dairy Farm in Makhado Local Municipality at Louis Trichardt, Limpopo Province, South Africa where a total of 50 lactating Holstein cows were used. Pearson’s correlation technique was used for data analysis. Findings between body measurement traits and milk yield showed that milk yield had a highly positive significant (p ˂ 0.01) correlation with rump height (r = 0.55), and positive significant (p < 0.05) with withers height (r = 0.44) and body length (r = 0.42). Results between udder measurement traits and milk yield showed that milk yield had a highly positive significant (p < 0.01) correlation with udder length before milking (r = 0.57), udder circumference before milking (r = 0.55) and udder circumference after milking (r = 0.51) The results also showed that milk yield had a positive significant (p < 0.05) correlation with teat diameter before milking (r = 0.30), teat length before milking (r = 0.31), teat circumference before milking (r = 0.36) and udder length after milking (0.47). The findings imply that all traits correlated with milk yield can be used to enhance milk yield of Holstein cows through selection during breeding.
Vol. 10, No. 3, December 2023: 335-340
Detection of gender bias in numeracy skills in Islamic boarding schools: Differential item functioning
Authors: Bahar Rosid , Firdaus Ahmad
Published: January 2024

Numeracy skills are an important point in the structure of mathematics, and boarding school students are no exception. This study aims to identify gender bias in numeracy assessment in Islamic boarding schools. This research is a descriptive exploratory research using quantitative methods. The instrument used in this study was a numeracy test of 25 questions consisting of matching, multiple-choice, complex multiple-choice, and description questions. The research subjects involved 383 students in West Java consisting of 4 pesantren in 4 cities, namely West Bandung Regency, Cirebon Regency, Tasikmalaya Regency, and Tasikmalaya City. Quantitative analysis used Item Response Theory (IRT) followed by Differential Item Functioning (DIF) analysis with the Mantel-Haenzel method. The results showed that the instrument was suitable for use because it met the standards of validity and reliability. The model fit test that meets is GPCM, and DIF analysis shows that there is 1 number, namely number 21, in numeracy questions that indicate gender bias. The results of this analysis indicate that the numeracy test instrument set is suitable for use by boarding school students with minimal gender bias.
Suppression of growth and endopeptidases of red palm weevil,Rhynchophorus ferrugineus (Olivier) infesting coconut using proteinase inhibitors
Authors: Joseph Rajkumar A. , Chandrika Mohan , V.K. Chaturvedi
Published: January 2024

Investigations on luminal proteinases of grubs of red palm weevil, hynchophorusÂ ferrugineus (Olivier) infesting coconut revealed presence of two endodpeptidases viz., trypsin (BApNA-ase activity) and elastase-like chymotrypsin (SAAPLpNA-ase activity) in all stages of larval development. Highest activity of these proteinases coincided with the active feeding stage (mid-larval stage) of the insect. Aprotinin 50 Ã¬g, Soybean Trypsin Inhibitor (SBTI) 50 Ã¬g and Phenyl Methyl Sulphonyl Fluoride (PMSF) 1700 Ã¬g inhibited trypsin activity of R. ferrugineus by 77.4%, 63.1% and 55.9%, respectively. Serine proteinase inhibitors viz., aprotinin (50 Ã¬g), SBTI (50 Ã¬g) and PMSF (1700 Ã¬g) had a marginal reduction of elastase - like chymotrypsin activity of R. ferrugineusÂ by 32%, 14% and 11%, respectively suggesting the serine nature of the proteinase. In vivo bioassay of 250 Ã¬M aprotinin on coconut petiole method using early stage grubs of R. ferrugineus indicated a significant weight loss of 18.9% due to incorporation of serine proteinase inhibitor, aprotinin in a period of 120 h. Possibility of using serine proteinase inhibitor, aprotinin in the management ofÂ R. ferrugineus was suggested.Â