bluuebunny/crossref_metadata_2025 huggingface dataset:
Echocardiographic measure of dynamic arterial elastance predict pressure response during norepinephrine weaning: an observational study
Authors: Nguyen Maxime , Abou-Arab Osama , Bar Stéphane , Dupont Hervé , Bouhemad Bélaïd , Guinot Pierre-Grégoire
Published: February 2021

The purpose of this study was to determine whether dynamic elastance EAdyn derived from echocardiographic measurements of stroke volume variations can predict the success of a one-step decrease of norepinephrine dose. In this prospective single-center study, 39 patients with vasoplegic syndrome treated with norepinephrine and for whom the attending physician had decided to decrease norepinephrine dose and monitored by thermodilution were analyzed. EAdyn is the ratio of pulse pressure variation to stroke volume variation and was calculated from echocardiography stroke volume variations and from transpulmonary thermodilution. Pulse pressure variation was obtained from invasive arterial monitoring. Responders were defined by a decrease in mean arterial pressure (MAP) > 10% following norepinephrine decrease. The median decrease in norepinephrine was of 0.04 [0.03–0.05] µg kg−1 min−1. Twelve patients (31%) were classified as pressure responders with a median decrease in MAP of 13% [12–15%]. EAdyn was lower in pressure responders (0.40 [0.24–0.57] vs 0.95 [0.77–1.09], p < 0.01). EAdyn was able to discriminate between pressure responders and non-responders with an area under the curve of 0.86 (CI95% [0.71 to1.0], p < 0.05). The optimal cut-off was 0.8. EAdyn calculated from the echocardiographic estimation of the stroke volume variation and the invasive arterial pulse pressure variation can be used to discriminate pressure response to norepinephrine weaning. Agreement between EAdyn calculated from echocardiography and thermodilution was poor. Echocardiographic EAdyn might be used at bedside to optimize hemodynamic treatment.
Emergence of network effects and predictability in the judicial system
Authors: Mones Enys , Sapieżyński Piotr , Thordal Simon , Olsen Henrik Palmer , Lehmann Sune
Published: February 2021

As courts strive to simultaneously remain self-consistent and adapt to new legal challenges, a complex network of of citations between decided cases is established. Using network science methods to analyze the underlying patterns of citations between cases can help us understand the large-scale mechanisms which shape the judicial system. Here, we use the case-to-case citation structure of the Court of Justice of the European Union to examine this question. Using a link-prediction model, we show that over time the complex network of citations evolves in a way which improves our ability to predict new citations. Investigating the factors which enable prediction over time, we find that the content of the case documents plays a decreasing role, whereas both the predictive power and significance of the citation network structure itself show a consistent increase over time. Finally, our analysis enables us to validate existing citations and recommend potential citations for future cases within the court.
Intensity of metastasis screening and survival outcomes in patients with breast cancer
Authors: Cheun Jong-Ho , Jung Jigwang , Lee Eun-Shin , Rhu Jiyoung , Lee Han-Byoel , Lee Kyung-Hun , Kim Tae-Yong , Han Wonshink , Im Seock-Ah , Noh Dong-Young , Moon Hyeong-Gon
Published: February 2021

Previous randomized trials, performed decades ago, showed no survival benefit of intensive screening for distant metastasis in breast cancer. However, recent improvements in targeted therapies and diagnostic accuracy of imaging have again raised the question of the clinical benefit of screening for distant metastasis. Therefore, we investigated the association between the use of modern imaging and survival of patients with breast cancer who eventually developed distant metastasis. We retrospectively reviewed data of 398 patients who developed distant metastasis after their initial curative treatment between January 2000 and December 2015. Patients in the less-intensive surveillance group (LSG) had significantly longer relapse-free survival than did patients in the intensive surveillance group (ISG) (8.7 vs. 22.8 months; p = 0.002). While the ISG showed worse overall survival than the LSG did (50.2 vs. 59.9 months; p = 0.015), the difference was insignificant after adjusting for other prognostic factors. Among the 225 asymptomatic patients whose metastases were detected on imaging, the intensity of screening did not affect overall survival. A small subgroup of patients showed poor survival outcomes when they underwent intensive screening. Patients with HR-/HER2 + tumors and patients who developed lung metastasis in the LSG had better overall survival than those in the ISG did. Highly intensive screening for distant metastasis in disease-free patients with breast cancer was not associated with significant survival benefits, despite the recent improvements in therapeutic options and diagnostic techniques.
Intraoperative perfusion assessment of the proximal colon by a visual grading system for safe anastomosis after resection in left-sided colorectal cancer patients
Authors: Ryu Hyo Seon , Lim Seok-Byung , Choi Eu-Tteum , Song Inho , Lee Jong Lyul , Kim Chan Wook , Yoon Yong Sik , Park In Ja , Yu Chang Sik , Kim Jin Cheon
Published: February 2021

We aimed to evaluate the clinical feasibility of a new visual grading system. We included 50 patients who underwent resection of primary colorectal cancer. Before anastomosis, the marginal vessel was cut and the perfusion status was assessed by a visual grading system. The visual grading system is comprised of five grades according to the bleeding from the marginal vessel and is categorized into 4 groups: good (grade A and B), moderate (grade C), poor (grade D) and none (grade E). Colorectal anastomosis was performed only in the good and moderate groups. We compared postoperative outcomes between the good and moderate groups and analysed the factors affecting the perfusion grade. Among the patients, 48% were grade A, 12% were grade B, and 40% were grade C. There was no anastomotic leakage. Only one patient with grade C showed ischemic colitis and needed reoperation. Age was the only factor correlated with perfusion grade in multivariate analysis (OR 1.080, 95% CI 1.006–1.159, p = 0.034). The perfusion grades were significantly different between > 65 and < 65 year-old patients (> 65, A 29.2% B 12.5% C 58.3% vs. < 65, A 65.4% B 11.5% C 23.1%, p = 0.006). Our intraoperative perfusion assessment that uses a cutting method and a visual grading system is simple and useful for performing a safe anastomosis after colorectal resection. If the perfusion grade is better than grade C, an anastomosis can be performed safely. Age was found to be an important factor affecting the perfusion grade.
Transcriptomic responses of Aspergillus flavus to temperature and oxidative stresses during aflatoxin production
Authors: Tian Fei , Lee Sang Yoo , Woo So Young , Choi Hwa Young , Heo Seongeun , Nah Gyoungju , Chun Hyang Sook
Published: February 2021

Aflatoxin is a group of polyketide-derived carcinogenic and mutagenic secondary metabolites produced by Aspergillus flavus that negatively impact global food security and threaten the health of both humans and livestock. Aflatoxin biosynthesis is strongly affected by the fungal developmental stage, cultivation conditions, and environmental stress. In this study, a novel float culture method was used to examine the direct responses of the A. flavus transcriptome to temperature stress, oxidative stress, and their dual effects during the aflatoxin production stage. The transcriptomic response of A. flavus illustrated that the co-regulation of different secondary metabolic pathways likely contributes to maintaining cellular homeostasis and promoting cell survival under stress conditions. In particular, aflatoxin biosynthetic gene expression was downregulated, while genes encoding secondary metabolites with antioxidant properties, such as kojic acid and imizoquins, were upregulated under stress conditions. Multiple mitochondrial function-related genes, including those encoding NADH:ubiquinone oxidoreductase, ubiquinol-cytochrome C reductase, and alternative oxidase, were differentially expressed. These data can provide insights into the important mechanisms through which secondary metabolism in A. flavus is co-regulated and facilitate the deployment of various approaches for the effective control and prevention of aflatoxin contamination in food crops.
Sarcoplasmic reticular Ca2+-ATPase inhibition paradoxically upregulates murine skeletal muscle Nav1.4 function
Authors: Liu Sean X. , Matthews Hugh R. , Huang Christopher L.-H.
Published: February 2021

Skeletal muscle Na+ channels possess Ca2+- and calmodulin-binding sites implicated in Nav1.4 current (INa) downregulation following ryanodine receptor (RyR1) activation produced by exchange protein directly activated by cyclic AMP or caffeine challenge, effects abrogated by the RyR1-antagonist dantrolene which itself increased INa. These findings were attributed to actions of consequently altered cytosolic Ca2+, [Ca2+]i, on Nav1.4. We extend the latter hypothesis employing cyclopiazonic acid (CPA) challenge, which similarly increases [Ca2+]i, but through contrastingly inhibiting sarcoplasmic reticular (SR) Ca2+-ATPase. Loose patch clamping determined Na+ current (INa) families in intact native murine gastrocnemius skeletal myocytes, minimising artefactual [Ca2+]i perturbations. A bespoke flow system permitted continuous INa comparisons through graded depolarizing steps in identical stable membrane patches before and following solution change. In contrast to the previous studies modifying RyR1 activity, and imposing control solution changes, CPA (0.1 and 1 µM) produced persistent increases in INa within 1–4 min of introduction. CPA pre-treatment additionally abrogated previously reported reductions in INa produced by 0.5 mM caffeine. Plots of peak current against voltage excursion demonstrated that 1 µM CPA increased maximum INa by ~ 30%. It only slightly decreased half-maximal activating voltages (V0.5) and steepness factors (k), by 2 mV and 0.7, in contrast to the V0.5 and k shifts reported with direct RyR1 modification. These paradoxical findings complement previously reported downregulatory effects on Nav1.4 of RyR1-agonist mediated increases in bulk cytosolic [Ca2+]. They implicate possible local tubule-sarcoplasmic triadic domains containing reduced [Ca2+]TSR in the observed upregulation of Nav1.4 function following CPA-induced SR Ca2+ depletion.
Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia
Authors: Hofmans Mattias , Lammens Tim , Depreter Barbara , Wu Ying , Erlacher Miriam , Caye Aurélie , Cavé Hélène , Flotho Christian , de Haas Valerie , Niemeyer Charlotte M. , Stary Jan , Van Nieuwerburgh Filip , Deforce Dieter , Van Loocke Wouter , Van Vlierberghe Pieter , Philippé Jan , De Moerloose Barbara
Published: February 2021

Juvenile myelomonocytic leukemia (JMML) treatment primarily relies on hematopoietic stem cell transplantation and results in long-term overall survival of 50–60%, demonstrating a need to develop novel treatments. Dysregulation of the non-coding RNA transcriptome has been demonstrated before in this rare and unique disorder of early childhood. In this study, we investigated the therapeutic potential of targeting overexpressed long non-coding RNAs (lncRNAs) in JMML. Total RNA sequencing of bone marrow and peripheral blood mononuclear cell preparations from 19 untreated JMML patients and three healthy children revealed 185 differentially expressed lncRNA genes (131 up- and 54 downregulated). LNA GapmeRs were designed for 10 overexpressed and validated lncRNAs. Molecular knockdown (≥ 70% compared to mock control) after 24 h of incubation was observed with two or more independent GapmeRs in 6 of them. For three lncRNAs (lnc-THADA-4, lnc-ACOT9-1 and NRIR) knockdown resulted in a significant decrease of cell viability after 72 h of incubation in primary cultures of JMML mononuclear cells, respectively. Importantly, the extent of cellular damage correlated with the expression level of the lncRNA of interest. In conclusion, we demonstrated in primary JMML cell cultures that knockdown of overexpressed lncRNAs such as lnc-THADA-4, lnc-ACOT9-1 and NRIR may be a feasible therapeutic strategy.
Printed oxygen gas sensor using copper-DTDTPA solid electrolyte
Authors: Priyadarshni Nivedita , Mandal Soumen , Ganesan Supradeepa Panual , Halder Saurav , Roy Debolina , Chanda Nripen
Published: February 2021

Copper-DTDTPA adsorbed on filter paper shows solid electrolyte behavior for its application in solid state oxygen gas sensors.
Rapid analysis of anionic and cationic surfactants in water by paper spray mass spectrometry
Authors: Min Ke , Yang Qinglan , Zhong Xiangjing , Yan Donglan , Luo Wei , Fang Zhengfa , Xiao Jing , Ma Ming , Chen Bo
Published: February 2021

We present the development of PS-MS into an analytical tool for the study of surfactants in water samples. The method has a short analysis time, low solvent consumption, no need for sample pretreatment and simultaneous multi-surfactant detection.
The discovery of SKLB-0335 as a paralog-selective EZH2 covalent inhibitor
Authors: Zhang Qiangsheng , Hu Xi , Li Lu , Zhang Lidan , Wan Guoquan , Feng Qiang , Zhu Yongxia , Wang Ningyu , Liu Zhihao , Yu Luoting
Published: February 2021

This study provides a simple and practical strategy for the selective inhibition of EZH2 without affecting the biological function of EZH1.
BNB-doped phenalenyls – aromaticity switch upon one-electron reduction
Authors: Crumbach Merian , Ayhan Ozan , Fritze Lars , Sprenger Jan A. P. , Zapf Ludwig , Finze Maik , Helten Holger
Published: February 2021

Fully aromatic, fluorescent, and highly robust BNB-doped phenalenyls were prepared via ring expansion, which undergo an aromaticity switch upon reduction.
Three-dimensional bipedal DNA walker enabled logic gates responding to telomerase and miRNA
Authors: Liu Xin , Meng Fanyu , Sun Rui , Wang Kangnan , Yu Zhiqiang , Miao Peng
Published: February 2021

Gold nanoparticle mediated bipedal DNA walkers are fabricated for logic gate operations responding to telomerase and miRNA.
Direct imidation of lactones via catalytic oxo/imido heterometathesis
Authors: Rumyantsev Andrey V. , Pichugov Andrey V. , Bushkov Nikolai S. , Aleshin Dmitry Yu. , Strelkova Tatyana V. , Lependina Olga L. , Zhizhko Pavel A. , Zarubin Dmitry N.
Published: February 2021

We report the first examples of catalytic oxo/imido heterometathesis reactions that involve carboxylic acid derivatives (lactones).
Insight into the formation of H-bonds propagating the monomeric zinc complexes of a tridentate reduced Schiff base to form an infinite chain
Authors: Karmakar Mainak , Frontera Antonio , Chattopadhyay Shouvik
Published: February 2021

The formation of an infinite 1D assembly is governed by the H-bonding interactions in the solid state structure of the two zinc complexes. It has been analyzed energetically using DFT calculations and several computational tools.
Material properties particularly suited to be measured with helium scattering: selected examples from 2D materials, van der Waals heterostructures, glassy materials, catalytic substrates, topological insulators and superconducting radio frequency materials
Authors: Holst Bodil , Alexandrowicz Gil , Avidor Nadav , Benedek Giorgio , Bracco Gianangelo , Ernst Wolfgang E. , Farías Daniel , Jardine Andrew P. , Lefmann Kim , Manson Joseph R. , Marquardt Roberto , Artés Salvador Miret , Sibener Steven J. , Wells Justin W. , Tamtögl Anton , Allison William
Published: February 2021

This paper presents material properties particularly suited to be measured with helium scattering techniques. Below a specific science case example illustrating the measurement of the electron–phonon coupling constant λ on a topological insulator surface.
Concentration and size effects on the size-selective particle purification method using the critical Casimir force
Authors: Villanueva-Valencia José Ramón , Guo Hongyu , Castañeda-Priego Ramón , Liu Yun
Published: February 2021

The particle aggregation is found to be size sensitive for systems with either a short-ranged or long-ranged attraction introduced by the binary solvent fluctuation. This effect is utilized to purify particles by size.
Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application
Authors: Zhao Xueze , Liu Jiangping , Fan Jiangli , Chao Hui , Peng Xiaojun
Published: February 2021

Molecular design directions for overcoming the photodynamic therapy challenges.
Antiviral drug discovery: preparing for the next pandemic
Authors: Adamson Catherine S. , Chibale Kelly , Goss Rebecca J. M. , Jaspars Marcel , Newman David J. , Dorrington Rosemary A.
Published: February 2021

SARS-CoV-2, EBOV and emerging RNA viruses are amongst the most important global health threats; yet clinically approved antiviral drugs are available for only 10 of the more than 220 viruses known to infect humans.
Luminescent metal–organic frameworks as chemical sensors based on “mechanism–response”: a review
Authors: Huangfu Mengjie , Wang Man , Lin Chen , Wang Jian , Wu Pengyan
Published: February 2021

The comprehensive review systematically summarizes the recent developments in the study of LMOFs as chemical sensors based on “mechanism–response”.
Photorelease of a metal-binding pharmacophore from a Ru(ii) polypyridine complex
Authors: Karges Johannes , Stokes Ryjul W. , Cohen Seth M.
Published: February 2021

As a potential prodrug concept, a metal-binding metalloenzyme inhibitor fragment can be released via light from a Ru(ii) polypyridine complex.
Tuning the properties of CoFe-layered double hydroxide by vanadium substitution for improved water splitting activity
Authors: Singh Baghendra , Indra Arindam
Published: February 2021

Here, we demonstrate the enhanced water splitting activity of CoFe–LDH by vanadium substitution.
Increased residual lithium compounds guided design for green recycling of spent lithium-ion cathodes
Authors: Fan Min , Chang Xin , Guo Yu-Jie , Chen Wan-Ping , Yin Ya-Xia , Yang Xinan , Meng Qinghai , Wan Li-Jun , Guo Yu-Guo
Published: February 2021

Based on the increased residual lithium compounds of the degraded cathode, a green water-based strategy is designed for achieving closed-loop recycling of spent lithium-ion batteries.
Mechanochemical preparation of thermoplastic cellulose oleate by ball milling
Authors: Hou De-Fa , Li Meng-Lei , Yan Cong , Zhou Ling , Liu Zheng-Ying , Yang Wei , Yang Ming-Bo
Published: February 2021

Mechanochemical esterification of cellulose with a low dosage of oleic acid was developed to obtain thermoplastic cellulose oleates with the assistance of ball-milling.
Anticorrosion allyl sulfonate graft chitosan/graphene oxide nanocomposite material
Authors: Eduok Ubong , Ohaeri Enyinnaya , Szpunar Jerzy
Published: February 2021

A novel organic/inorganic hybrid allyl sulfonate graft chitosan/graphene oxide nanocomposite material is synthesized, characterized and utilized as a corrosion inhibitor for an X70 pipeline steel substrate in CO2saturated brine at 60 °C.
Electrochemical exfoliation of a graphite electrode in 1-ethyl-3-methylimidazolium chloride-[EMIM]+Cl−–AlCl3 ionic liquid and its electrocatalytic application
Authors: Saravanan Gengan , Sanjay Sankaranarayanan , Gnanamuthu R. M. , Sankararao Mutyala
Published: February 2021

An eco-friendly and economically viable electrochemical exfoliation method has the potential to produce few-layer graphene as a support for a dendritic Pt nanoparticle modified electrode for better non-enzymatic electrooxidation of glucose.
Synthesis, characterization and antibacterial applications of pyrazolyl-sulfonamides and their palladium complexes
Authors: Amoah Cephas , Obuah Collins , Ainooson Michael Kojo , Adokoh Christian Kwaku , Muller Alfred
Published: February 2021

Pyrazolylsulphonamides compounds and their palladium complexes exhibiting good potential anti-bacterial activities.
Insight into the impact of EGFR L792Y/F/H mutations on sensitivity to osimertinib: anin silicostudy
Authors: Chen Daoxing , Zhang Liting , Liu Yanan , Song Jiali , Guo Jingwen , Wang Longxin , Xia Qinqin , Zheng Xiaohui , Cai Yuepiao , Hong Chenglv
Published: February 2021

EGFR L792Y/F/H mutation makes it difficult for Osimertinib to recognize ATP pockets.
Metal-free graphene-based nanoelectrodes for the electrochemical determination of ascorbic acid (AA) andp-nitrophenol (p-NP): implication towards biosensing and environmental monitoring
Authors: Sapner Vijay S. , Sathe Bhaskar R.
Published: February 2021

Herein, tyramine functionalized graphene oxide electrocatalyst is used for the electrochemical determination of ascorbic acid and p-nitrophenol in 1 M phosphate buffer solution at pH-7  with long term current/potential stability and reproducibility.
Understanding the insertion reactions of CO2, aldehyde and alkene into Cu–X (X = B, C, O) bonds
Authors: Guo Xueying , Lin Zhenyang
Published: February 2021

The relative preference of different unsaturated organic molecules (CO2, PhCHO and styrene) for insertion into different Cu–X (X = B, C, O) bonds has been systematically examined with the aid of DFT calculations.
Biosynthesis of azaphilones: a review
Authors: Pavesi Coralie , Flon Victor , Mann Stéphane , Leleu Stéphane , Prado Soizic , Franck Xavier
Published: February 2021

Biosynthetic pathways for azaphilones are addressed from a genomic point of view.
Amphiphilic Janus nanoparticles for imaging-guided synergistic chemo-photothermal hepatocellular carcinoma therapy in the second near-infrared window
Authors: Chen Xiangjun , Zhang Xiuping , Zhang Lingyu , Gao Yuzhou , Wang Changrong , Hong Wei , Zhao Guodong , Li Lu , Liu Rong , Wang Chungang
Published: February 2021

The unique amphiphilic oleic acid-NaYF4:Yb,Er/polydopamine Au nanoflower Janus NPs with the discrete multi compartment nanostructures as dual-drug delivery systems are fabricated, which exhibit a novel strategy for efficiently combating HCC.
Fabrication of 2D/2D COF/SnNb2O6 nanosheets and their enhanced solar hydrogen production
Authors: Ren Jianlin , Xia Zhenglong , Luo Bifu , Li Di , Shi Weidong
Published: February 2021

2D TpPa-2-COF tightly decorated on the surface of SnNb2O6 nanosheets effectively increases the interface region, promotes separation of carriers and heightens charge utilization rate, thus achieving better solar H2-production activity than bare SnNb2O6 and TpPa-2-COF.
Ultraviolet nonlinear optical crystals A3SrBi(P2O7)2(A = K, Rb) with large second harmonic generation responses
Authors: Liu Shiwei , Zhang Bingbing , Wu Hongping , Yu Hongwei , Hu Zhanggui , Wang Jiyang , Wu Yicheng
Published: February 2021

Two non-centrosymmetric pyro-phosphates of K3SrBi(P2O7)2and Rb3SrBi(P2O7)2have short UV cut-off edges (∼240 nm) and large SHG responses.
High-rate and non-toxic Na7Fe4.5(P2O7)4@C for quasi-solid-state sodium-ion batteries
Authors: Du Guangyuan , Tao Mengli , Qi Yuruo , Gao Wei , Bao Shu-juan , Xu Maowen
Published: February 2021

A quasi-solid-state sodium-ion battery based on the Na7Fe4.5(P2O7)4@C cathode boosts high-rate performance and long lifespan.
The enhancement of treatment capacity and the performance of phytoremediation system by fed batch and periodic harvesting
Authors: Ng Yin Sim , Chan Derek Juinn Chieh
Published: February 2021

Spirodela polyrhiza FBH system had 150% more treatment capacity, up to 5.2× higher removal in NH3–N, PO43−, TSS and COD.
In situ electro-organic synthesis of hydroquinone using anisole on MWCNT/Nafion modified electrode surface and its heterogeneous electrocatalytic reduction of toxic Cr(vi) species
Authors: Gandhi Mansi , Rajagopal Desikan , Senthil Kumar Annamalai
Published: February 2021

MWCNT-surface confined Hydroquinone/quinone redox system is prepared in situ method and used for mediated reduction of Cr(vi) species
Visualizing chemistry teachers’ enacted assessment design practices to better understand barriers to “best practices”
Authors: Schafer Adam G. L. , Borland Victoria M. , Yezierski Ellen J.
Published: February 2021

Even when chemistry teachers’ beliefs about assessment design align with literature-cited best practices, barriers can prevent teachers from enacting those beliefs when developing day-to-day assessments. In this paper, the relationship between high school chemistry teachers’ self-generated “best practices” for developing formative assessments and the assessments they implement in their courses are examined. Results from a detailed evaluation of several high school chemistry formative assessments, learning goals, and learning activities reveal that assessment items are often developed to require well-articulated tasks but lack either alignment regarding representational level or employ only one representational level for nearly all assessment items. Implications for the development of a chemistry-specific method for evaluating alignment are presented as well as implications for high school chemistry assessment design.
Visually precise, low-damage, single-cell spatial manipulation with single-pixel resolution
Authors: Zhang Qi , Shao Yunlong , Li Boye , Wu Yuanyuan , Dong Jingying , Zhang Dongtang , Wang Yanan , Yan Yong , Wang Xiayan , Pu Qiaosheng , Guo Guangsheng
Published: February 2021

We achieved the low-damage spatial puncture of single cells at specific visual points with an accuracy of <65 nm.
Benzylic C(sp3)–C(sp2) cross-coupling of indoles enabled by oxidative radical generation and nickel catalysis
Authors: Kim Weonjeong , Koo Jangwoo , Lee Hong Geun
Published: February 2021

A mechanistically distinct Ni-catalysed benzylic functionalization of indoles is developed by the facile oxidation of arenes. The method exhibits a wide substrate scope and pronounced chemoselectivity that cannot be accessed via known protocols.
Anisotropic mass transport using ionic liquid crystalline electrolytes to suppress lithium dendrite growth
Authors: Gopalakrishnan Deepesh , Alkatie Samia , Cannon Andrew , Rajendran Sathish , Thangavel Naresh Kumar , Bhagirath Neha , Ryan Emily M. , Arava Leela Mohana Reddy
Published: February 2021

Suppressing lithium dendrite growth using anisotropic mass transport in ionic liquid crystalline electrolytes.
Direct observation of long chain enrichment in flow-induced nuclei from molecular dynamics simulations of bimodal blends
Authors: Anwar Muhammad , Graham Richard S.
Published: February 2021

Modelling of flow-induced nucleation in polymers suggest that long chains are enriched in nuclei, relative to their melt concentration.
Yield stress “in a flash”: investigation of nonlinearity and yielding in soft materials with an optofluidic microrheometer
Authors: Vitali Valerio , Nava Giovanni , Corno Andrea , Pezzotti Melissa , Bragheri Francesca , Paiè Petra , Osellame Roberto , Ortenzi Marco Aldo , Cristiani Ilaria , Minzioni Paolo , Bellini Tommaso , Zanchetta Giuliano
Published: February 2021

An optical active microrheology technique, capable of high forces, is proposed for yield stress measurements.
Dilatancy, shear jamming, and a generalized jamming phase diagram of frictionless sphere packings
Authors: Babu Varghese , Pan Deng , Jin Yuliang , Chakraborty Bulbul , Sastry Srikanth
Published: February 2021

Frictionless packings exhibit dilatancy and shear jamming, contrary to previous expectations, depending crucially on the existence of a “jamming line” above the minimal jamming density (J-Point), and with strikingly different rheological behaviour.
Effect of core hydrophobicity on the electrophoresis of pH-regulated soft particles
Authors: Bharti  , Gopmandal Partha P. , Sinha R. K. , Ohshima H.
Published: February 2021

We propose a theoretical study on the electrophoresis of pH-regualted soft particles considering the effect of hydrodynamic slip length of the hydrophobic inner core.
Nanoboxes with a porous MnO core and amorphous TiO2 shell as a mediator for lithium–sulfur batteries
Authors: Yang Jinhua , Yang Xianfeng , Cheong Jian Liang , Zaghib Karim , Trudeau Michel L. , Ying Jackie Y.
Published: February 2021

Nanoboxes with a porous MnO core and amorphous TiO2 shell have been synthesized via a wet-chemistry method for the first time.
A high-flux organic solvent nanofiltration membrane with binaphthol-based rigid-flexible microporous structures
Authors: Fu Wenming , Zhang Wei , Chen Haonan , Li Shao-Lu , Shi Wenxiong , Hu Yunxia
Published: February 2021

A binaphthol-based microporous polymer membrane with high microporosity exhibits excellent OSN performance.
Single- and double-helices of α,α′-dibenzylaminotripyrrin: solution and solid state studies
Authors: Ueta Kento , Umetani Masataka , Osuka Atsuhiro , Pantoş G. Dan , Tanaka Takayuki
Published: February 2021

α,α′-Di(benzylamino)tripyrrin was synthesized, which exhibited an equilibrium between single- and double-helical forms in solution. XRD analysis showed its co-crystal structure including both forms.
A review on the recently developed promising infrared nonlinear optical materials
Authors: Abudurusuli Ailijiang , Li Junjie , Pan Shilie
Published: February 2021

The synthesis, characterization and performance of the new developed promising IR NLO materials with outstanding performances and good crystal growth habits are summarized and analyzed.
Correction: The chemopreventive effects of Huangqin-tea against AOM-induced preneoplastic colonic aberrant crypt foci in rats and omics analysis
Authors: Shen Jie , Li Pei , Liu Shuangshuang , Liu Qing , Li Yue , Zhang Zheng , Yang Chengmin , Hu Mengying , Sun Yuhua , He Chunnian , Xiao Peigen
Published: February 2021

Correction for ‘The chemopreventive effects of Huangqin-tea against AOM-induced preneoplastic colonic aberrant crypt foci in rats and omics analysis’ by Jie Shen et al., Food Funct., 2020, 11, 9634–9650, DOI: 10.1039/D0FO01731K.
Synthesis of ultra-high molecular weight poly(ethylene)-co-(1-hexene) copolymers through high-throughput catalyst screening
Authors: Williams Thomas J. , Lamb Jessica V. , Buffet Jean-Charles , Khamnaen Tossapol , O'Hare Dermot
Published: February 2021

Permethylindenyl titanium CGCs supported on solid polymethylaluminoxane (sMAO) are investigated as slurry-phase catalysts by high-throughput catalyst screening (copolymerisation of ethylene/1-hexene with incorporation levels up to 14.2 mol%).
Constructing a hollow microflower-like ZnS/CuS@C heterojunction as an effective ion-transport booster for an ultrastable and high-rate sodium storage anode
Authors: Zhao Wenxi , Gao Lixia , Yue Luchao , Wang Xiaoyan , Liu Qian , Luo Yonglan , Li Tingshuai , Shi Xifeng , Asiri Abdullah M. , Sun Xuping
Published: February 2021

Hollow microflowers-like ZnS/CuS@C heterojunction as an anode material for sodium storage delivers large reversible capacity, ultralong cycling life and competitive rate capability.
Ego‐lane index‐aware vehicular localisation using the DeepRoad Network for urban environments
Authors: Lee Soomok , Choi Jinwoo , Seo Seung‐Woo
Published: February 2021

Accurate real‐time localisation is crucial for various autonomous driving applications. Numerous methods for localization, combining various kinds of input such as data from environmental sensors, inertial measurement units, and the Global Positioning System, have been proposed. Given the present state of affairs with regards to map compactness and sensor affordability, lane map‐matching‐based methods with cameras used as environmental sensors have been widely proposed. In previous methods, however, lanes detected by cameras could falsely correspond to other lanes in a map. This would result in inaccuracies such as a two‐lane or three‐lane deviation from the actual pose. This paper proposes a localisation method integrating the ego‐lane index to avoid lane deviations during lane map matching. A novel ego‐lane index identification algorithm and methodology to integrate the ego‐lane index information into the lane‐based map‐matching function is presented. It is demonstrated that incorporating ego‐lane index information improves the accuracy of map‐matching localisation. The efficacy of our approach in diverse environments, including complex urban scenarios, was successfully demonstrated.
Modelling the He I triplet absorption at 10 830 Å in the atmospheres of HD 189733 b and GJ 3470 b
Authors: Lampón M. , López-Puertas M. , Sanz-Forcada J. , Sánchez-López A. , Molaverdikhani K. , Czesla S. , Quirrenbach A. , Pallé E. , Caballero J. A. , Henning T. , Salz M. , Nortmann L. , Aceituno J. , Amado P. J. , Bauer F. F. , Montes D. , Nagel E. , Reiners A. , Ribas I.
Published: February 2021

Characterising the atmospheres of exoplanets is key to understanding their nature and provides hints about their formation and evolution. High resolution measurements of the helium triplet absorption of highly irradiated planets have been recently reported, which provide a new means of studying their atmospheric escape. In this work we study the escape of the upper atmospheres of HD 189733 b and GJ 3470 b by analysing high resolution He I triplet absorption measurements and using a 1D hydrodynamic spherically symmetric model coupled with a non-local thermodynamic model for the He I triplet state. We also use the H density derived from Lyα observations to further constrain their temperatures, mass-loss rates, and H/He ratios. We have significantly improved our knowledge of the upper atmospheres of these planets. While HD 189733 b has a rather compressed atmosphere and small gas radial velocities, GJ 3470 b, on the other hand with a gravitational potential ten times smaller, exhibits a very extended atmosphere and large radial outflow velocities. Hence, although GJ 3470 b is much less irradiated in the X-ray and extreme ultraviolet radiation, and its upper atmosphere is much cooler, it evaporates at a comparable rate. In particular, we find that the upper atmosphere of HD 189733 b is compact and hot, with a maximum temperature of 12 400−300+400 K, with a very low mean molecular mass (H/He = (99.2/0.8) ± 0.1), which is almost fully ionised above 1.1 RP, and with a mass-loss rate of (1.1 ± 0.1) × 1011 g s−1. In contrast, the upper atmosphere of GJ 3470 b is highly extended and relatively cold, with a maximum temperature of 5100 ± 900 K, also with a very low mean molecular mass (H/He = (98.5/1.5)−1.5+1.0), which is not strongly ionised, and with a mass-loss rate of (1.9 ± 1.1) × 1011 g s−1. Furthermore, our results suggest that upper atmospheres of giant planets undergoing hydrodynamic escape tend to have a very low mean molecular mass (H/He ≳ 97/3).
Radiation protection study for a reloading operation of cobalt 60 sources in the Moroccan ionisation station using the GEANT4 Monte-Carlo simulation code
Authors: Aknouch Adil , El-ouardi Youssef , Mouhib Mohammed , Sebihi Rajaa , Choukri Abdelmajid
Published: February 2021

The operation of reloading the irradiators is considered among the tasks requiring high radiation protection monitoring, to protect the intervening manipulators, the public and the environment. Morocco is among the countries that have a cobalt irradiator, installed at the National Institute of Agricultural Research (NIAR) of Tangier, to carry out research in the field of agronomy. In the beginning, the irradiator used low doses of activity for the study of products only, for treatment of high doses. The NIAR carried out a reload to increase the activity. To perform this, a temporary pool was installed inside the irradiation room to handle the sources safely. A radiation protection study is necessary to ensure the safe operation. This operation requires a height level of exposure. To ovoid the exposer risk, it is proposed to use the Monte Carlo method thanks to its reliability in the dosimetric calculation. This article presents a radiation protection study of the Moroccan irradiator reloading operation using the GEANT4 Monte-Carlo Simulation Code.
Control of physicochemical parameters of spring waters near quarries exploiting limestone rock
Authors: Fattah Ghizlane , Ghrissi Fouzia , Mabrouki Jamal , Kabriti Mohamed
Published: February 2021

The goal behind this work is defined as the study of the quality of water from karst springs near quarries exploiting limestone rock in order to assess its adequacy with domestic uses. At that end, a study at the mountain level was carried out. This mountain is in the Haouz area, in Tetouan, which is located north of Morocco and shelters active quarries. This research is based on the assessment of the physico-chemical parameters of the spring water used by local residents and located near this industry. The water quality evaluation was carried out by comparing the recorded values, according to Moroccan Standards related to the quality of water for human use. The review of some parameter’s indicative of water pollution (T °, pH, electrical conductivity, dissolved oxygen, turbidity, total dissolved solids and the alkalimetric total title) revealed that the quality of the studied spring water is good and does not present any health risk to the users of this water during the winter season.
The first step in removing communication and organizational barriers to stakeholders’ interaction in Smart Grids: A theoretical approach
Authors: Vakulenko Ihor , Saher Liudmyla , Syhyda Liubov , Kolosok Svitlana , Yevdokymova Alona
Published: February 2021

This research is the first step in scientific work on the formation of organizational and communication system stakeholders` interaction in Smart Grid. This theoretical research studies the cooperation of stakeholders under the logical and meaningful process of initiation, design, implementation, and development of Smart Grid projects. According to researches analysis in this area and the best practice approaches to the development of Smart Grids, a stakeholder` interaction matrix has been formed. The peculiarity of the developed matrix is taking into account the stages and directions (key aspects) of the Smart Grids development. It forms the basis for a systematic analysis of the problem under study. So the designed matrix will be used as a component of the formation of the stakeholders` interaction logicalstructural scheme. The development of this scheme is an intermediate stage in modeling the interaction of stakeholders. The research results presented in this paper are the first theoretical step in a multi-stage study of stakeholder interaction.
Renewable energy innovation in Europe: Energy efficiency analysis
Authors: Kolosok Svitlana , Myroshnychenko Iuliia , Mishenina Halyna , Yarova Inessa
Published: February 2021

In this manuscript, we investigate the importance of renewable energy innovation for achieving inclusive and sustainable goals and the state’s energy security. Emphases in research are made on investigation the effect of regulatory policies and fiscal incentives on achieving renewable energy targets. Exploiting energy data for 28 European countries over the period 1990–2018, we assess the relationship between the volumes of renewable energy and energy efficiency. The statistical analysis we performed in Python. Our results indicate that the share of energy from renewable positively correlates with all energy efficiency indicators except energy productivity.
Factors influencing responsible consumption in health crisis context: Moroccan case study
Authors: Zaghli Mariam , Attouch Hicham
Published: February 2021

After the appearance of COVID-19 and its spread to the four corners of the globe, the decision to contain it has become more democratic in all countries, and the measures that go with it too. Citizens found themselves forced to anticipate and think carefully about their trips, which necessarily impacted their consuming way. The concept of responsible consumption has been discussed by several researchers, on economic, social, cultural and environmental aspects, but their interpretations are very rare or even untraceable in a context of pandemic, lockdown period and health and environmental crisis. A conceptual model was proposed in this study, exclusively devoted to the factors influencing responsible purchasing behavior in a situation of health and environmental crisis, by means of a quantitative study addressed to Moroccan Internet users, in order to see their motivations for using "home-shopping" in a context of health crisis and in a period of lockdown. The expected results have enabled us to understand the purchasing behavior of individuals, and thus be able to explain the predominant factors in pre-purchase decision making. Our article is divided into three parts. The first part is dedicated to the presentation of the existing literature, the second present the methodology and scientific tools used in our empirical. Then in a third and final part, we will present the results of our quantitative empirical study.
Green finance: Pandemic and climate change
Authors: Klioutchnikov Igor , Kliuchnikov Oleg
Published: February 2021

In the last decade, green finance has become an important area of tackling the environmental threats associated with climate change and a prerequisite for sustainable development. The Covid-19 outbreak has drawn additional attention to green finance as an economic mechanism for creating healthy living environments. The article examines the impact of COVID-19 on the financial industry, the participation of green finance in the economic recovery after the pandemic in the direction of considering the Paris Agreement on reducing greenhouse gas emissions. The authors put forward the provision on the existence of causal relationships between the "green" financial and "green" economy: "green" finance (reason) is a mechanism for the formation of a "green" economy (consequence). The impact of green finance on society can be greatly enhanced through changes in lifestyles, the behaviour of people and companies, legislative initiatives and government decisions aimed at protecting the health and the environment; climate change and the pandemic have increased the overall fragility of development and created additional risks that are factored into green finance. The article substantiates the position that the global pandemic will have a long-term impact on people's attitudes towards the environment and on the financing of this area. As uncertainty grows about protecting people from disease and mitigating climate change, green finance may become the mainstream of finance.
Economic efficiency of road transport vehicles of fleet and its impact on commercial indices and production plan of a motor transport enterprise
Authors: Podvalna Halina , Bochko Olena , Kuziak Viktoriia , Stasyuk Nazar
Published: February 2021

At the current stage of development of the branch of motor transport in Ukraine, satisfactory equipment of enterprises with the fixed assets, particularly motor transport enterprises, is one of the main problems. Fleet of road transport vehicles of those enterprises needs almost complete renovation, and productive-technical base for maintenance inspection and repair of transport requires complete technical re-equipment. The aim of the work is to develop theoretical approaches and practical recommendations concerning maintenance of road transport vehicles of motor transport enterprises, choice of the type of transportation means and determination of the necessary number of vehicles depending on the production plan of their operation.
The implementation of the occupational health and safety management system according to OHSAS 18001/2007 in a Moroccan telecommunication company
Authors: Benakka Latifa , Zogaam Gharbi Loubna , Bacroume Said , Bejjaji Zohra , Aouane Mahjoub
Published: February 2021

Integrated environmental, health and safety management systems are a new management paradigm in modern organizations. These systems are built on the ISO 14001 and OHSAS 18001 standards, based on risk prevention and the precautionary principle. The study is carried out in a telecommunications company in Morocco. The objective is the definition of an approach that will promote the protection of its employees against the risks they face and not only prepare them for obtaining safety certification. It has become necessary to have a new approach to occupational safety, which is part of the overall management of the company, and this project has touched him. In fact, this study has tried to guarantee the best working conditions and the presentation of the employees' rights, as well as to reduce the indirect costs resulting from occupational diseases and accidents at work. In other words, the internal audit carried out demonstrated compliance with the main requirements of OHSAS 18001 regarding environmental, health and occupational safety management.
The benefits of preserving and promoting cultural heritage values for the sustainable development of the country
Authors: Vu Hoang Khoa
Published: February 2021

Cultural and natural heritages are considered invaluable resources, creating a unique tourist attraction for each country. However, knowing how to use this heritage for sustainable tourism development, while preserving and promoting the heritage value for future generations is not a simple task. This article focuses on the values of cultural heritage and the importance of maintaining and promoting it while integrating with the environment for the development of society. It discusses the current state of cultural heritage preservation and promotion in Vietnam, showing examples of development with disregard to the heritage and the environment, why it is necessary to have sustainable development in active culture conservation, as well as the relationship between the preservation, promotion of the cultural heritage and the socio-economic development and the environment. A perspective on the cultural heritage value in sustainable development is also given. Through the reading of supporting materials and the comparison of survey data, it is clear that the preservation of cultural values not only contribute directly to the socio-economic development of a country similar to Vietnam, but also to help create new values in later generations. Therefore, it is concluded that a sustainable approach to the conservation of cultural heritages is very important for the future handling of such irreplaceable resources.
The geological and hydrogeological characteristics of Tamelast landfill site in Agadir, Morocco
Authors: Asouam Saadia , Faik Farid , El Morjani Zine El Abidine , Abioui Mohamed
Published: February 2021

The Grand Agadir is confronting with huge production of solid waste. Due to the fact of changes in habits of consumption, the increase of production, and demographic evolution. This production is buried in the controlled discharge of Tamelast. This landfill faces many environmental issues. Our work aims to evaluate the environmental characteristics based on the geological and hydrogeological properties of the site of the Tamelast landfill in Grand Agadir (Morocco). To evaluate the geological and hydrogeological characteristics of the Tamelast landfill, we have generated geological, hydrogeological maps, stratigraphic vertical sections, and cross-sections of the landfill area that have been prepared for further assessment of environmental geological factors. Besides, we also focused on other measures of permeability, and field data we could define the probability and importance of contamination by leachate. The Tamelast landfill is installed on the marl-limestone and carbonate ranges of the Campanian and Maastrichtian. Geologically, the site consists essentially of carbonate deposits, limestones, and Cretaceous marls. These geological outcrops that can play the role of a potential aquifer are the fractured Campanian marl-limestone formations. These soils have a permeability of 5.10-4 to 10-3m/s and transmissivity of 10-2 to 5.10-2 m2/s.