bluuebunny/crossref_metadata_2025 huggingface dataset:
Electroneuromyography: a modern view on the possibilities of application (literature review)
Authors: Morozov A. M. , Sorokovikova T. V. , Minakova Yu. E. , Belyak M. A.
Published: June 2022

Relevance. Currently, one of the most informative specific methods for diagnosing damage to the spinal cord and peripheral nervous system is electroneuromyography. This complex electrophysiological method is based on the registration, analysis and evaluation of the obtained potentials that arise during the work of the studied skeletal muscles of the patient during the passage of impulses along the peripheral nerve fibers. A feature of this method is the variety of parameters obtained: from the characteristics of the evoked potential itself – its latent period, shape, amplitude and duration, to obtaining the number of functioning motor units of the muscle fiber, the speed of the impulse of both motor and sensory innervation.

The purpose of study. To analyze the current understanding of the possibilities of using the electroneuromyography method in clinical practice.

Materials and methods. In the course of this study, an analysis was made of foreign and domestic literature of recent years on the possibility of using the method of electroneuromyography in adult and pediatric neurological practice.

Results. The rapid development of electroneuromyography in recent years makes it possible to use two main areas: stimulation electroneuromyography (ENMG) and needle, which is currently mainly used abroad. ENMG is a method that does not require invasive intervention, which allows you to assess the state of the studied nerve in different areas, giving an understanding of the nature of the nerve lesion, as well as the degree of its damage. At the moment, there are clear indications for the use of this particular method in clinical practice, namely for polyneuropathies of any genesis, plexopathies, neuropathies and neuritis of any genesis, neural amyotrophies, tunnel syndromes, myasthenia gravis and osteochondrosis of the spine with radicular syndrome. In turn, needle electroneuromyography is an invasive method, but more accurate and highly informative, allowing to assess the functional state of the peripheral neuromotor apparatus. At the same time, this method allows you to identify the disease at an early stage of development, the localization of the pathology, the nature and degree of activity, as well as to indicate the degree of damage to the muscle fiber and the possibility of its further recovery. It is recommended to use this method as a specific diagnosis of amyotrophic lateral sclerosis, spinal amyotrophy, myotonia, myopathy of various origins, hereditary muscle diseases, paraneoplastic myopathies, and so on.

Conclusion. The possibilities of using electroneuromyography currently continue to expand due to the popularity of the method as a diagnostic of the state of the neuromuscular system due to the specificity of indicators, the possibility of diagnosing many diseases at the subclinical stage, the ease of monitoring parameters in dynamics, the possibility of non-invasive use and an accurate assessment of the effectiveness of therapy.
Neurophysiological parameters in patients with hallux valgus
Authors: Verkhozina T. K. , Ippolitova E. G. , Kinash I. N. , Tsyslyak E. S. , Butaev Ch. Z. , Puseva M. E.
Published: June 2022

We examined 38 patients (35 women and 3 men aged 30–40 years) with stage 2 and 3 hallux valgus in the department of traumatology and orthopedics of the Irkutsk Scientific Centre of Surgery and Traumatology to study the electroneuromyographic parameters during stimulation of the peripheral nerves of the lower extremities. All patients underwent electroneuromyographic study of peripheral nerves (n. tibialis and n. peroneus) to clarify the nature of their injuries. In 10 patients, the parameters of the monosynaptic H-reflex were additionally studied. Analysis of electroneuromyographic parameters in patients with hallux valgus demonstrated a deterioration in the peripheral nerves functioning, which was more pronounced for the tibial nerve (n. tibialis). At the same time, the parameters of the monosynaptic H-reflex obtained in patients with hallux valgus indicate the presence of a neurological deficit observed in the compression of the L5–S1 roots of the spinal cord in lumbar osteochondrosis. The results of the study suggest the presence of a single pathogenetic mechanism for the development of degenerative processes in the spinal joints (osteochondrosis) and limbs (deforming osteoarthrosis of large and small joints).
Identificação de deficiências em textos educacionais com a aplicação de processamento de linguagem natural e aprendizado de máquina
Authors: Pinho Cíntia Maria de Araújo , Moura Amanda Ferreira de , Gaspar Marcos Antonio , Napolitano Domingos Márcio Rodrigues
Published: June 2022

A correção de textos educacionais como redações e questões discursivas é uma tarefa importante, além disso, diversas escolas têm exigido a intensificação da atividade da escrita para a evolução do discente. Entretanto, o esforço despendido para a correção pode aumentar a carga de trabalho do professor ou até mesmo gerar custos adicionais, bem como um longo tempo de correção para instituições como o MEC (Ministério da Educação), que é responsável pela aplicação do ENEM (Exame Nacional do Ensino Médio). Em 2019 foi anunciado pelo MEC a tendência do ENEM se tornar digital, trazendo novas possibilidades para a análise e avaliação das redações elaboradas pelos estudantes. Neste contexto, algumas técnicas de inteligência artificial para análise de textos educacionais tem se revelado úteis no processo de avaliação automática da linguagem escrita. Assim, o objetivo desta pesquisa é analisar textos empregando para tanto as técnicas de Processamento de Linguagem Natural e Aprendizado de Máquina para identificar deficiências em textos educacionais. Esta pesquisa experimental consistiu na classificação de 695 redações elaboradas em língua portuguesa em 20 temas. Os resultados demonstraram que as técnicas empregadas possibilitaram a identificação de redações cujo conteúdo foge à temática proposta na prova, dentre outras informações importantes para que o docente possa identificar falhas na escrita da redação, tais como a coesão textual ou texto insuficiente. Os resultados esperados com a aplicação da solução desenvolvida neste experimento buscam otimizar o trabalho do professor, bem como reduzir o tempo e o custo do processo de avaliação de textos educativos.
CORONAVIRUS-RELATED ANXIETY WITH HYPERGLYCEMIA IN TYPE 2 DIABETES PATIENTS
Authors: Hikmah Kholisotul , Helda Helda , Killeen Caroline
Published: June 2022

Background: COVID-19 might also predispose individuals to elevate blood glucose as the effect of anxiety. Blood glucose level is an important risk factor for the prognosis of disease among diabetes patients.  Purpose: This study aimed to assess the effect of Coronavirus-related anxiety with hyperglycemia incidence among type 2 diabetes patients. Methods: A cross-sectional study was conducted among 143 individuals with type 2 diabetes mellitus, from 25 January to 29 February 2021. This study was conducted both online and by assessing archives of medical records using random samples.  Results: A total of 143 respondents completed the questionnaire, with 59.44% females and 40.56% males. More than half of the respondents (55.94%) who reported hyperglycemia showed COVID-19 anxiety, and 51.05% of them experienced ≥ 8 years of diabetes. COVID-19 anxiety was associated positively with the risk of hyperglycemia among type 2 diabetes patients (PR>1). Severe worry about the pandemic had the highest risk of hyperglycemia compared to moderate and mild anxiety. This finding is confounded by diabetes duration (PR discrepancy >10% and PR>1 for ≥8 years long-duration). Conclusion: This study suggests a positive association between COVID-19 anxiety and hyperglycemia while the degree of anxiety is associated with an increased risk of hyperglycemia.
TYPE 2 DIABETES MELLITUS, ANEMIA, AND HYPERTENSION AS THE RISK FACTORS THAT AFFECT THE INCIDENCE OF METASTATIC BREAST CANCER
Authors: Elmika Elma , Budijitno Selamat , Suwondo Ari
Published: June 2022

Background: Breast cancer is one of the most common gynecologic malignancies in women and the main cause of death in 25% of all cases. The main cause of death from breast cancer is metastases, it is estimated that 5-10% of breast cancers have metastasized at the time of early diagnosis with an advanced stage. Purpose: To analyze the risk factors that influence the incidence of metastases in patients with advanced breast cancer. Methods: This study is an analytic observational study with a cross-sectional design, the number of samples in the study was 120 patients. The inclusion criteria of the study sample were breast cancer patients with advanced stages III and IV in the last five years. Exclusion criteria were incomplete patient medical records. The sampling technique in this study was consecutive sampling. This research was conducted at Ibnu Sina Hospital, Makassar City. The variables analyzed in this study were type 2 diabetes mellitus, anemia, and hypertension which were tested with the chi-square test. Results: The results of this study showed that diabetes mellitus type 2 (p=0.00; Prevalence Rate [PR]=1.79; 95% CI=1.32-2.42) and anemia (p=0.03; Prevalence Rate [PR] = 1.82; 95% CI = 1.61-2.86) is a risk factor that affects the incidence of metastases in patients with advanced breast cancer. While the risk factor that has no effect is hypertension. Conclusion: Type 2 diabetes mellitus and anemia are risk factors that influence the incidence of metastases in breast cancer patients.
The Role of Emotional Eating A Mediator in Relationship between Sleep Duration and Quality with Carbohydrate Intake among Pregnant Women
Authors: Agrisdian Zerly , Probandari Ari , Pamungkasari Eti
Published: June 2022

Carbohydrate is one of the nutrients that is needed during pregnancy. Increased demand during pregnancy causes pregnant women to consume carbohydrates in excess, which occurs due to emotional eating. The increment of emotional eating is assumed to be triggered by insufficient sleep duration and poor sleep quality. This study was aimed to investigate the role of emotional eating as mediator in relationship between sleep duration and quality with carbohydrate intake among pregnant women. This study applied an analytic survey with cross-sectional design on 105 pregnant women in the second and third trimesters at Bondowoso District were sampled through multistage random sampling technique. In this study, the exogenous variables were sleep duration and quality. Meanwhile, the endogenous variables were carbohydrate intake. Emotional eating was the mediator. Data were collected using the Emotional Eater Questionnaire (EEQ), Pittsburgh Sleep Quality Index (PSQI), and 3×24 hours food recall. Data were analyzed using path analysis. There was a direct relationship between duration and quality of sleep with emotional eating (P <0.001 dan 0.002). Sleep duration and quality were not directly associated to carbohydrate intake (P 0.817 dan 0.z724). A direct relationship was shown by emotional eating and carbohydrate intake variables (P<0.001). It is concluded that emotional eating plays a role in the indirect relationship between sleep duration and quality with carbohydrate intake for pregnant women in the second and third trimesters. Pregnant women should be able to regulate sleep patterns and dietary intake.
Parenting Patterns and Family Characteristics among Stunted Toddlers in Palembang
Authors: Sari Indah Purnama , Ardillah Yustini , Yuliarti Yuliarti
Published: June 2022

Until today, there are still more than 20% children under five years old experiencing stunting due to malnutrition over a long time both in Indonesia and also globally. Therefore, an integrated program is needed to reduce the prevalence of stunting. This study investigated the correlation between parenting patterns and family characteristics with stunting. A matched case-control design was used based on age. Up to 40 cases and 40 controls of mothers having toddlers aged 24-59 months were selected as samples using simple random sampling technique. This study was conducted in Seberang Ulu I Sub-District, Palembang City, from September to October 2020. The data that has been collected were analyzed using univariate and bivariate analysis. The result showed that stunted and normal toddlers were mostly from mothers with poor parenting patterns in terms of feeding (72.5% & 45.0%), hygiene and sanitation (35.0% & 32.5%), and health care (42.5% & 15.0%). In addition, more cases of stunting came from mothers with high school education and below, low-income, at least 4 family members, and having more than 1 toddler. Feeding pattern, health care pattern, and mother’s education affect toddlers’ growth. The risk of stunting was higher in toddlers raised by mothers with low education, with poor feeding and health care practices than else.
Ovarian cancer recurrence: “is the definition of platinum resistance modified by PARP inhibitors and other intervening treatments?”
Authors: Pejovic Tanja , Fitch Katherine , Mills Gordon
Published: June 2022

PolyADP ribose polymerase inhibitors (PARPi) have transformed the treatment of ovarian cancer. Particularly in high-grade serous ovarian cancer (HGSOC), a disease characterized by homologous recombination deficiency (HRD), PARPi have had a rapid and profound impact on the disease course, as well as biologic and biomarker definitions of HGSOC, thereby creating a paradigm shift in the approach to treatment. In this review, we discuss the role of PARPi in the maintenance treatment of HGSOC, its effect on platinum sensitivity, and cross-resistance between platinum and PARP inhibitors.
Recent progress and perspective of multifunctional integrated zinc-ion supercapacitors
Authors: Li Yue , Yang Wen , Han Lu , Li Huijun , Wen Zhiguo , Li Yan , Wang Xiaoguang , Sun Hengchao , Lu Ting , Xu Min , Pan Likun
Published: June 2022

Zinc-ion supercapacitors (ZISCs) are recognized as one of the most promising types of energy storage devices with the advantages of high theoretical capacity and safety, nontoxicity, low cost, abundant resources (~300 times higher than lithium), and lightweight. So far, multifunctional integrated ZISCs have greatly broadened their application scenarios. In addition to enhancing the electrochemical performance via the design of advanced electrodes and electrolytes, the complex application scenarios and in-depth development of energy storage devices have resulted in higher requirements for ZISCs with multifunctional integrated applications. However, to the best of our knowledge, there is no relevant review about summarizing advanced multifunctional ZISCs. In this review, various advanced multifunctional ZISCs, including micro, self-powered integrated, antifreezing, and stretchable ZISCs, are comprehensively presented to fully understand the advanced evolution of multifunctional ZISCs. The working principles and challenges of ZISCs are analyzed and the future development directions and expectations of advanced multifunctional ZISCs are discussed. This review provides significant guidance for the multifunctional development of ZISCs for future studies.
A Simplistic and Cost Effective Design for Real-World Development of Ambient Assisted Living Systems for Fall Detection and Indoor Localization: Proof of Concept
Authors: Thakur Nirmalya , Han Chia Y.
Published: June 2022

Falls, highly common in the constantly increasing global aging population, can have a variety of negative effects on their health, well-being, and quality of life, including restricting their capabilities to conduct Activities of Daily Living (A.D.L.s), which are crucial for one's sustenance. Timely assistance during falls is highly necessary, which involves tracking the indoor location of the elderly during their diverse navigational patterns associated with A.D.L.s to detect the precise location of a fall. With the decreasing caregiver population on a global scale, it is important that the future of intelligent living environments can detect falls during A.D.L.s while being able to track the indoor location of the elderly in the real world. Prior works in these fields have several limitations, such as – lack of real-world testing, lack of functionalities to detect both falls and indoor locations, high cost of implementation, complicated design, the requirement of multiple hardware components for deployment, and the necessity to develop new hardware or software for implementation, which make the wide-scale deployment of such technologies challenging. To address these challenges, this work proposes a simplistic design paradigm for an Ambient Assisted Living system with functionalities to perform indoor localization and fall detection during A.D.L.s. The results from real-world experiments uphold the effectiveness of the system to capture multimodal components of the user interaction data during A.D.L.s that are necessary for performing fall detection and indoor localization. To add to the above, a comparison study is also presented, which shows that the cost for the development of this system is the least as compared to prior works in the fields of fall detection, indoor localization, and assisted living, which involved real-world development, thereby upholding the cost-effective nature of the proposed system.
Analysis on Dynamic Relationship and Optimization Path between Public Sports Service and New Urbanization Development in Mainland China
Authors: Zhou Rong , Cui Jinghang
Published: June 2022

In the new period, the state has made every effort to promote the new urbanization of public sports service. Entropy method, coupled coordination model, cold hot spot analysis is used to explore the dynamic relationship between public sports services and the development of new urbanization in China from 2008 to 2017. The results show that: (1) The development of the internal subsystem of public sports service is not balanced, the sports financial investment system grows rapidly, but the development of professional sports talent team is slow. (2) The imbalance of regional development cannot be ignored, and the public sports service level shows a decreasing gradient from east to west. (3) The regional development features are different. The eastern region is dominated by the coordinated development of sports public service and urbanization, while the central region is mainly in the type of public sports service lag, while the western region has multiple complex characteristics of low-level coordination and public sports service lag. Therefore, it is proposed that the construction of modern public sports service system should be investigated in the context of the development of new urbanization. It should be promoted from the following aspects: promoting the extension of public sports service to rural areas, engendering the "citizen's right" of sports health to the migrant population, conforming to the trend of mass sports intelligence, developing green sports and revitalizing idle sports assets in cities.
Formation of Stable Cruciform Assembly of Gold Nanoparticles from Cannabis Indica Leaves
Authors: Khadria Anjul , Paul Subhankar
Published: June 2022

Gold nanoparticles have been increasingly used in several electronic, material fabrication, and biomedical applications. Several methods have been reported to prepare gold nanoparticles of various shapes and sizes with different photophysical properties. Although useful to prepare gold nanoparticles, most of the methods are not stable enough and undergo degradation, if stored at room temperatures (up to 30 °C) for a few days. In this paper, we report a novel environmentally friendly method to synthesize self-assembled gold nanoparticles in cruciform shapes by using leaf extract of Cannabis indica as a reducing agent without the aid of any polymers or additional chemicals. The nanoparticles are found to be stable for more than a month when stored at room temperature (30 °C). They were able to form stable conjugates with bovine α-lactalbumin protein that may possess anti-cancerous properties.
UAV Remote Sensing for High-Throughput Phenotyping and for Yield Prediction of Miscanthus by Machine Learning Techniques
Authors: Impollonia Giorgio , Croci Michele , Ferrarini Andrea , Brook Jason , Martani Enrico , Blandinières Henri , Marcone Andrea , Awty-Carroll Danny , Ashman Chris , Kam Jason , Kiesel Andreas , Trindade Luisa M. , Boschetti Mirco , Clifton-Brown John , Amaducci Stefano
Published: June 2022

Miscanthus holds a great potential in the frame of the bioeconomy and yield prediction can help improving Miscanthus logistic supply chain. Breeding programs in several countries are attempting to produce high-yielding Miscanthus hybrids better adapted to different climates and end-uses. Multispectral images acquired from unmanned aerial vehicles (UAVs) in Italy and in the UK in 2021 and 2022 were used to investigate the feasibility of high-throughput phenotyping (HTP) of novel Miscanthus hybrids for yield prediction and crop traits estimation. An intercalibration procedure was performed using simulated data from the PROSAIL model to link vegetation indices (VIs) derived from two different multispectral sensors. Random forest algorithm estimated with good accuracy yield traits (light interception, plant height, green leaf biomass and standing biomass) using VIs time series and predicted yield using peak descriptor derived from VIs time series with 2.3 Mg DM ha-1 of RMSE. The study demonstrates the potential of UAVs multispectral in HTP applications and in yield prediction for providing important information needed to increase sustainable biomass production.
Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework
Authors: Clerbaux Laure-Alix , Albertini Maria Cristina , Amigó Núria , Beronius Anna , Bezemer Gillina F.G. , Coecke Sandra , Daskalopoulos Evangelos P. , Del Giudice Giusy , Greco Dario , Grenga Lucia , Mantovani Alberto , Muñoz Amalia , Omeragic Elma , Parissis Nikolaos , Petrillo Mauro , Saarimäki Laura A. , Soares Helena , Sullivan Kristie , Landesmann Brigitte
Published: June 2022

Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows that outcomes are markedly heterogeneous between patients. This requires identifying the factors and understanding how they mechanistically influence COVID-19. Here, we describe how eleven selected factors influence COVID-19 by applying the Adverse Outcome Pathway (AOP) framework well-established in regulatory toxicology. This framework aims to model the sequence of events starting from an initial interaction of a stressor with the organism and the progress through key biological events leading to an adverse health outcome. Several linear AOPs depicting pathways from the binding of the virus to ACE2 up to clinical outcomes observed in COVID-19 patients have been developed and integrated into a network offering a unique overview of the mechanisms underlying the disease. As SARS-CoV-2 infectibility and ACE2 activity are the major starting points and inflammatory response is central in the development of COVID-19, we evaluated how eleven intrinsic and extrinsic factors modulate those processes impacting clinical outcomes. Applying this AOP-aligned approach enables the identification of current knowledge gaps orientating for further research and allows to propose biomarkers to identify of high-risk patients. This approach also facilitates expertise synergy from different disciplines to address public health issues.
Factors Influencing Environmental Conservation Agriculture (ECA) Continuation in Sado Island, Niigata Prefecture, Japan
Authors: Maharjan Keshav Lall , Gonzalvo Clarisse Mendoza , Aala Wilson Jr. Florendo
Published: June 2022

Sado Island in Niigata prefecture, Japan is one of the first Globally Important Agricultural Heritage Systems (GIAHS) among developed countries and has since been involved in environmental conservation agriculture (ECA). While ECA is still in its early stage in Japan, it has proven to be effective in mitigating climate change in the agricultural sector; hence, this study analyzed the factors which could contribute to the ECA continuation among Sado Island farmers. The data revealed the prevalence of farmers’ cognitive dissonance between ECA and its mitigating effects on climate change. Exploratory factor analysis and ordinal regression confirmed the importance of perceived GIAHS involvement in the continuation of ECA. In addition, other identified factors affecting ECA continuation fall either on a macro-level (i.e., farmers’ awareness of their role in improving their environment) or micro-level (i.e., farmers’ differing farm optimizations). These perspectives highlighted the altruistic nature of the Sado Island ECA farmers by valuing the improvement of their local and global environment as their main reason to continue ECA, whereas their various farm management optimizations support this observed farmer altruism by providing avenues to increase yield with only a moderate paddy land area. This study thereby highlights the need to continuously develop sustainable strategies to maintain and improve a positive farmer mindset towards ECA.
Digital Transition in Rural Emergency Medicine: Impact of Job Satisfaction and Workload on Communication and Technology Acceptance
Authors: Hasebrook Joachim , Michalak Leonie , Kohnen Dorothea , Metelmann Bibiana , Metelmann Camilla , Brinkrolf Peter , Flessa Steffen , Hahnenkamp Klaus
Published: June 2022

Background: Tele-emergency physicians (TEPs) take an increasingly important role in the need-oriented provision of emergency patient care. To improve emergency medicine in rural areas, we set up the project Land|Rettung (English: Rural|Rescue), which uses TEPs to restructure professional rescue services using information and communication technologies (ICTs) in order to reduce the therapy-free interval. Successful implementation of ICTs relies on user acceptance and knowledge sharing behavior. Methods and findings: We conducted a factorial design with active knowledge transfer and technology acceptance as a function of work satisfaction (high vs. low), workload (high vs. low) and point in time (prior to vs. after digitalization). Data were collected via machine readable questionnaires issued to 755 persons (411 pre, 344 post), of which 304 or 40.3% of these persons responded (194 pre, 115 post).Technology acceptance was higher after the implementation of TEP for nurses but not for other professional groups, and it was higher when the workload was high. Regarding active communication and knowledge sharing, employees with low work satisfaction are more likely to share their digital knowledge as compared to employees with high work satisfaction. Additional and more detailed analyses reveal that this is an effect of previous knowledge concerning digitalization. After implementing the new technology, work satisfaction increased for the more experienced employees, but not for the less experienced ones. Results are discussed considering the Dunning-Kruger effect. The Dunning-Kruger effect describes a cognitive bias. People with high expertise often underestimate their actual skill level. They have a more critical attitude towards their performance and feel the urgent need to fill possible knowledge gaps they notice. Conclusions: Our research illustrates that employees’ workload has an impact on the intention of using digital applications. The higher the workload, the more people are willing to use TEPs. Regarding active knowledge sharing, we see that employees with low work satisfaction are more likely to share their digital knowledge compared to employees with high work satisfaction. This might be attributed to the Dunning-Kruger effect. Highly knowledgeable employees initially feel uncertain about the change, which translates into temporarily lower work satisfaction. They feel the urge to fill even small knowledge gaps, which in return leads to higher work satisfaction. Those responsible need to acknowledge that digital change affects their employees’ workflow and work satisfaction. During such times, employees need time and support to gather information and knowledge in order to cope with digitally changed tasks.
FAIR Sharing of Reproducible Models of Epidemic and Pandemic Forecast
Authors: Ramachandran Kausthubh , König Matthias , Scharm Martin , Nguyen Tung V. N. , Hermjakob Henning , Waltemath Dagmar , Malik Sheriff Rahuman S.
Published: June 2022

A major challenge for the dissemination, replication, and reuse of epidemiological forecasting studies during COVID-19 pandemics is the lack of clear guidelines and platforms to exchange models in a Findable, Accessible, Interoperable, and Reusable (FAIR) manner, facilitating reproducibility of research outcomes. During the beginning of pandemics, models were developed in diverse tools that were not interoperable, opaque without traceability and semantics, and scattered across various platforms - making them hard to locate, infer and reuse. In this work, we demonstrate that implementing the standards developed by the systems biology community to encode and share COVID-19 epidemiological models can serve as a roadmap to implement models as a tool in medical informatics, in general. As a proof-of-concept, we encoded and shared 24 epidemiological models using the standard format for model exchange in systems biology, annotated them with cross-references to data resources, packed up all associated files in COMBINE archives for easy sharing, and finally, disseminated the models through BioModels repository to significantly enhance their reproducibility and repurposing potential. We recommend the use of systems biology standards to encode and share models of epidemic and pandemic forecasts to improve their findability, accessibility, interoperability, reusability, and reproducibility.
Investigations of the Influence the Sleep Disorders on Postural Stability in Young Men
Authors: Tetych Anna , Olchowik Grażyna , Warchol Jan
Published: June 2022

Lack of sleep is a factor that disrupts the receptors' reception of information from the environ-ment and contributes to the emergence of problems with maintaining balance. The main pur-pose of this study was to find out whether Computer Dynamic Posturography could be a useful tool in distinguishing between people who sleep well from people with insomnia. The study participants were 76 male students who were divided into groups based on the results obtained from the Pittsburgh Sleep Quality Questionnaire. In each group, postural stability had been tested using three main tests: Strategy Organization Test SOT, Motor Control Test MCT and Ad-aptation Test ADT. The results of the analysis show that the obtained results differ in the exam-ined groups under the SOT test. Among people with insomnia, higher values of the tested pa-rameters were noted, than with people who sleep well, which translates into a worse ability to maintain balance. The greatest impact is observed when using eyesight and a vestibular system to maintain a stable posture. It was confirmed that Computer Dynamic Posturography is used to differentiate between people who sleep well from people with insomnia in the group of men. Lack of sleep significantly disturbs postural stability.
Estimation of Aboveground Biomass (ABG) Using Allometric Equation: Case Study of Colo-I-Suva Forest Park in Fiji
Authors: Pipite Atanas
Published: June 2022

Forests play an important role in reducing greenhouse gases in the atmosphere, thereby mitigating the impact of climate change. Estimating the accumulated biomass in a forest ecosystem is important for assessing the productivity and sustainability of the forest. Allometric models for above ground biomass (AGB) are linear regression equations based on the relationships between biomass and diameter at breast height (DBH), tree height (H), and/or wood density. This study estimates AGB in the Colo-I-Suva Forest Park by applying the allometry of Chave et al (2005) and the diameter: height ratio derived from Payton & Weaver (2011) for height estimation in a plot of 20
Grit and Problem-solving Ability in Nursing Students: The Mediating Role of Distress Tolerance and Self-directedness
Authors: Kim Su Jin , Jang Gun Ja
Published: June 2022

Objectives: This study aimed to identify the mediating effects of distress tolerance and self-directedness on the relationship between grit and problem-solving ability in nursing students.Methods: Participants were 335 nursing students in two universities between September to December 2018. The data were analyzed using a t-test, one-way ANOVA, and Person’s correlation coefficients. In addition, Baron and Kenny’s method was used to analyze mediating effects of distress tolerance and self-directedness between grit and problem-solving ability.Results: Significant correlations were found between grit and problem-solving ability (r = 0.57, p< 0.001), between grit and distress tolerance (r = 0.38, p< 0.001), and grit and self-directedness (r = 0.46, p< 0.001). There were the mediating effects of distress tolerance (z = 5.37, p< 0.001) and self-directedness (z = 7.25, p< 0.001) on the relationship between grit and problem-solving ability.Conclusions: It is necessary to develop and apply the programs that strengthen distress tolerance and self-directedness to improve nursing students’ problem-solving ability.
Balancing IP Rights and Competition Law through Patent Pools in Indonesia: A Comparative Analysis
Authors: Sugarda Paripurna , Wicaksono Muhammad Rifky
Published: June 2022

In 1998, Heller and Eisenberg, discovered the ‘tragedy of the anticommons’ which occurs when there are numerous patent holders who must give their consent before a technology can be used. Consequently, where excessive property rights are claimed, some technology is underused, and innovation is stunted. To solve this issue, the patent owners can aggregate their patents into a single ‘patent pool.’ However, there are significant anticompetitive harms which may arise from such a practice. Hence, this paper aims to answer the question of whether the creation of patent pools as an antidote to the ‘tragedy of anticommons’ would be at the cost of competition law. This research found that it is possible to use patent pools as a solution to the tragedy of the anticommons, while preventing harm to competition. The Indonesian Competition Authority can take inspiration from EU regulations to create a ‘safeharbor’ for companies who engage in technology transfer agreements if they meet the market share thresholds. They can also improve the framework for analyzing patent pools by laying out the different categories of patents to ascertain the different levels of harm they bring to competition.
Hydrocarbon Accumulation Model Controlled by Overpressure Evolution in the Kelasu Thrust Belt of the Kuqa Depression, NW China
Authors: Liang Yilin , Liu Xianfeng , Wu Nan , Feng Yong , Wang Jian
Published: June 2022

The Kuqa Depression is the most representative overpressured hydrocarbon accumulation area in western China. The early rapid subsidence since 5 Ma and the strong uplift in the late period have led to a complicated evolution history of the overpressure. Three hydrocarbon charging episodes of Cretaceous in Kuqa Depression were identified based on petrography, microthermometry of fluid inclusions, and fluorescence spectroscopy characteristics. Low-maturity oil, represented by hydrocarbon inclusions with yellow-green-yellow fluorescence, entered the reservoir at circa 5-3 Ma, whereas high-maturity hydrocarbons, as indicated by hydrocarbon inclusions with blue-green-blue fluorescence, charged the reservoir at circa 3-1.2 Ma. Pure gas inclusions with nonfluorescence represented one episode of gas charging from approximately 1.2 Ma to the present. By applying the PVTX simulation method of inclusions, the paleo-pressure evolution of formations was reconstructed, that is, the three-stage model of pressurization-release-pressurization. The coupling relationship between the paleo-pressure evolution of formations and the history of hydrocarbon charging at different stages was reconstructed. This conformed to a compound overpressure-controlled hydrocarbon accumulation model with oil convergence in the early period, oil adjustment along the fracture in the middle period, and rapid gas charging in the late period.
Mapeamento de publicações da área de Português como Língua Adicional nas revistas Estudos Linguísticos (1978-2020) e Revista do GEL (2002-2020)
Authors: Granato Matheus
Published: June 2022

Neste trabalho, é apresentado um mapeamento das publicações da área de Português como Língua Adicional (PLA) nas 49 edições da revista Estudos Linguísticos (1978-2020) e 17 edições da Revista do GEL (2002-2020), ambas promovidas pelo Grupo de Estudos Linguísticos do Estado de São Paulo (GEL). O objetivo foi avaliar qual a presença de estudos em PLA nas publicações da associação e quais os contextos sociais e temas mais investigados. O estudo se baseou em pressupostos teórico-metodológicos da Historiografia Linguística, particularmente na técnica de mapeamento (COELHO; NÓBREGA; ALVES, 2021), e em bibliografia especializada sobre a área de PLA no Brasil (BRASIL, 2021; BULLA; KUHN, 2020; ROCHA, 2019).
Dicionário da COVID-19: compilação do corpus e levantamento dos termos
Authors: Costa Lucimara Alves da Conceição , Curti-Contessoto Beatriz , Alves Ieda Maria
Published: June 2022

Neste artigo, apresentamos um estudo preliminar sobre a temática da COVID-19 com base em dois corpora de estudo: o Corpus Oficial, composto de 993 textos sobre o coronavírus publicados em veículos oficiais, e o Corpus Jornalístico, constituído de 460 textos a respeito dessa temática. Neste trabalho, são apresentadas as fases iniciais do Dicionário em elaboração, que se referem à constituição do corpus de estudo. São também esboçadas algumas observações preliminares que o corpus constituído nos revela a respeito da terminologia da COVID-19. Nesse sentido, discutimos características gerais e iniciais desses textos que estão relacionadas não só a dados estatísticos, mas também às informações semânticas neles construídas. De modo particular, notamos, por meio dos padrões lexicais recorrentes em nossos corpora, que a pandemia trouxe transformações em nível vocabular que são o reflexo de novas formas de “viver” e “conviver” que nos foram impostas com o intuito de conter o contágio e a expansão do novo coronavírus.Palavras-chave: COVID-19; terminologia; corpus oficial; corpus jornalístico.
Considerações teórico-metodológicas sobre o processo de elaboração de materiais didáticos na formação de professores de línguas
Authors: Ramos Karin Adriane Henschel Pobbe , Carvalho Kelly Cristiane Henschel Pobbe de
Published: June 2022

O presente trabalho tem como objetivo propor algumas reflexões a respeito do processo de elaboração de materiais didáticos para aulas de línguas e seus atravessamentos na construção de identidades docentes, considerando as perspectivas do saber, do fazer, do poder e do ser docente. Para tanto, pautamo-nos em nossa trajetória como docentes, atuando em um Programa de Pós-Graduação em Letras e em um curso de Letras, orientando professores em formação continuada e licenciandos. As reflexões empreendidas estão alicerçadas em estudos que discutem os saberes docentes e o papel dos professores de línguas (TOMLINSON, 2001; BARROS; COSTA, 2010; GERALDI, 2015; CONTRERAS, 2012). Os resultados apontam a intrínseca relação entre a elaboração de materiais didáticos e os agenciamentos docentes. Palavras-chave: formação de professores de línguas; materiais didáticos; identidade.
Hydraulic Fracture Propagation in Denver-Julesburg Basin Constrained by Cross-Well Distributed Strain Measurements
Authors: Zhu Xiaoyu , Jin Ge
Published: June 2022

Evaluating hydraulic fracturing completion is critical for low porosity, low permeability unconventional reservoir development. In this study, we use low-frequency distributed acoustic sensing (LF-DAS) measurements to monitor the hydraulic fracturing in the Chalk Bluff field in the Denver-Julesburg (DJ) Basin, Colorado. Interpreting fracture-hits from crosswell LF-DAS data yields insights into the fracture geometry and propagation across and within two targeted formations: Niobrara and Codell. We observe significant differences in hydraulic fracture propagation between the two formations; the half length of hydraulic fractures in the Codell formation is much longer than that in the Niobrara. In addition, hydraulic fracture propagates significantly faster in Codell than in Niobrara under the same pumping rate. The differences could be explained by higher natural fracture density and potentially lower stress anisotropy in the Niobrara formation. We also observed different fracture orientations between the two formations and inconsistent fracture orientations within Niobrara. Hydraulic fractures observed in Codell oriented at 100 degree consistently, while two group of fracture azimuths (110 and 240 degrees) can be observed in Niobrara. The difference in fracture orientations in Niobrara and Codell indicates stress regime changes between the formations. The inconsistency of fracture azimuth in Niobrara may be caused by the zipper fracturing sequence. Strong cross-formation fracture connections between the two formations can also be observed, with different up-going and down-going fracture propagation velocities. These observations help us better understand the complex fracture geometry in the DJ Basin and provide critical constraints on the optimization of the unconventional reservoir development.
NAV2729 in combination with Imatinib promote apoptosis in chronic myeloid leukemia cell line, K562
Authors: Mardani Hajar , Shakerinia Zahra , Khalilabadi Roohollah Mirzaee , Fatemi Ahmad , Farsinejad Alireza
Published: June 2022

Background: Chronic myeloid leukemia (CML) is a hematologic malignancy that affect hematopoietic stem cells. CML therapy prevents the disease from spreading to more advanced stages and improve quality of life. Imatinib as the first line treatment for CML is associated with side effects and resistant. Tumor derived extracellular vesicles (TMVs) play an important role in the progression of the disease. Inhibiting the release of TMVs, helps to inhibit leukemia. Our purpose is to investigate the apoptotic effect of NAV2729 in combination with Imatinib on CML cell line, K562. Methods and Results: After treatment of K562 cells with NAV2729, Imatinib and both, viability of cells were measured after 24h, 48h. Metabolic activity, changes in Bax and Bcl-2 expressions, size and concentration of EVs were evaluated after 48h treatment of K562 cells with NAV2729, Imatinib and both. Trypan blue assay indicated, decremented live cells percentage. MTT assay showed reduction in metabolic activity when both of the drugs were used. Reduction in BCL-2 and BAX expressions was observed. EVs count release from K562 cells were decreased in the combination of drugs.Conclusion: study result showed combined treatment of NAV2729 and imatinib synergistically inhibit K562 cell proliferation and enhances the therapeutic effect of imatinib.
Tacrolimus-induced Reversible Cerebral Vasoconstriction Syndrome after Heart Transplant: Case Report
Authors: Inoue Koichi , Kainuma Satoshi , Yoshioka Daisuke , Toda Koichi , Miyagawa Shigeru
Published: June 2022

We describe the case of a patient with a recurrent severe headache that occurred after heart transplant surgery. She was diagnosed with reversible cerebral vasoconstriction syndrome (RCVS) since typical imaging was seen through brain contrast computed tomography. Tacrolimus, an immunosuppressant, was suspected as the cause of the RCVS. The treatment was switched to cyclosporine, after which there was rapid improvement of her symptoms. This case highlights the importance of an immediate diagnosis to switch immunosuppressants to relieve symptoms and prevent progression to severe neurological dysfunction.
Comparative chloroplast genomes of six Magnoliaceae species provides new insight into intergeneric relationship and phylogeny
Authors: Yang Lin , Tian Jinhong , Xu Liu , Zhao Xueli , Song Yuyang , Wang Dawei
Published: June 2022

The Magnoliaceae plants are industrial tree species with high medicinal value. We published the 6 complete chloroplast genomes of the family Magnoliaceae by using Illumina sequencing. These 6 chloroplast genomes showed a typical quadripartite structure of angiosperm and were 159,901 − 160,008 bp in size, respectively. A total of 324 microsatellite loci and 6 variable intergenic regions (Pi > 0.01) were identified in 6 genomes. Compare with other 5 genomes, the contraction and expansion of the IR regions were significantly different in Manglietia grandis. For having more thorough understanding of the intergeneric relationship of family Magnoliaceae, we also included 31 published chloroplast genomes of close relative species for phylogenetic analyses. The new insights into intergeneric relationship of family Magnoliaceae was provided based on the combination of our result and the previous morphological, phytochemical and anatomygical information. We suggest that the genus Yulania should be separated from the genus Michelia, and restore systematic position of the genus Yulania; the genera Paramichelia and Tsoongiodendron should be merged into the genera Michelia; the genera Pachylarnax and Parakmeria should be combined into one genus. These findings will provide a theoretical basis for adjustment phylogenetic position of family Magnoliaceae at the molecular level.
Mapping lineaments using Landsat 8 OLI and SRTM in the Boumalne-Imiter regions of the southern Central High Atlas. Morocco
Authors: said moujane , Algouti Ahmed , Algouti Abdellah , Farah Abdelouahd
Published: June 2022

This work presents the results of the automatic extraction of lineaments in the region of Boumalne-Imiter, which is located on the southern front of the Central High Atlas. These lineaments are extracted by remote sensing and Geographic Information System (GIS) approaches. These approaches are based on the first principal component (PC1) and the panchromatic band (B8), which are derived from a Landsat 8 OLI satellite image. These data underwent a 3*3 matrix directional filtering, with the addition of a shading effect on the digital terrain module STRM. These treatments allowed us to establish a synthetic lineament map of the study area. It consists of 1251 lineaments whose length varies between 407.75 m and 8.7 km and whose distribution is dominated by the class with lengths varying between 400 m and 1422 m. The direction of the lineaments is dominated by three families respectively, NE-SW, ENE-WSW and E-W. The density map shows a high intensity in the Saghro Massif (Eastern Anti-Atlas) and in the area that extends between the village of Ait Ibrirne and Arg-n-Sidi Ali Oubourk. Validation of these results is based on comparison of the synthetic map with the geological maps, the high-resolution satellite image (ESRI), in addition to two factors for validation. The first of these is the lithological factor, which shows us that the lineaments are often focused in the competent rocks, as is the case of the magmatic rocks of Saghro Massif in the south-east and also the limestones of the Jurassic and Paleocene-Eocene in the north. However, the second factor is the superimposition of the lineaments on the map of the slopes. This reflects that the concentration of lineaments is quite marked in places where the slopes are steep by steep, while the abrupt change of slopes is probably generated by the play of faults. The correlation of these results with previous work allows us to say that the area is made up of two domains. The first corresponds to the poly-orogenic Anti-Atlas with a very important tectonic heritage. The second is attached to the Atlasic domain, influenced by the southern Atlasic accident which is expressed by overlaps that occurred during the Atlasic uplift. The method of automatic extraction of structural lineaments is considered a useful reference technique due to its validity and accuracy in the selection of structural lineaments, and is considered as having an additional value in this type of study.