bluuebunny/crossref_metadata_2025 huggingface dataset:
Membangun Identitas Desa Wisata Tajuk melalui Website menggunakan Metode Waterfall : Analisis Komunikasi dan Strategi Digital Branding
Authors: Buana Chandra Lukita , Pamungkas Rifky Januar Adi , Muntaha Rama Faisal , Umami Zahrotul
Published: December 2024

Digital transformation plays a strategic role in introducing tourist villages, by utilizing digital technology to reach a wider tourism market. This study aims to build an integrated website that functions as a communication and branding medium for Tajuk Tourism Village. This website was developed using a waterfall software development model, with the main objective of increasing the visibility and attractiveness of Tajuk Tourism Village, as well as encouraging increased local income through village services and products. The result of this development is the Tajuk Smart Tourism website, which has been successfully created and hosted so that it can be accessed by the general public. This website uses XAMPP as a database manager, as well as HTML, PHP, CSS, Javascript, and Unity to present interactive content. This website not only provides practical information such as location, accommodation, and tourist activities, but is also able to build the image and identity of Tajuk Tourism Village as a superior tourist destination. The use of visual elements such as high-quality photos and videos, interesting narratives, and attractive designs, contribute to the creation of a virtual experience that changes tourists' perceptions of this village. In addition, the significant increase in visitors from 615 people per month to 900-1,200 people per month shows the success of the website in attracting more tourists. The income of the village community also increased rapidly, from 1 million rupiah per month to 6.6 million to 8.85 million rupiah per month. The website also provides great benefits to the local community, by opening up new opportunities in the tourism, homestay, and local product sectors. As a result, the website serves as an asset that supports village branding and increases its competitiveness in the digital tourism industry.
Analisis Kepuasan Pengguna dalam Penerapan E-Procurement pada Divisi Supply Chain Management PT ASDP Indonesia Ferry (Persero) Kantor Pusat
Authors: Annadiyanti Annisa Agni , Andrian Rian
Published: December 2024

This study aims to analyze the level of user satisfaction in the use of the E-Procurement system in the Supply Chain Management Division of PT. ASDP Indonesia Ferry (Persero) Head Office. The method used is quantitative with the Partial Least Squares-Structural Equation Modeling (PLS-SEM) approach using SmartPLS 3.2.9 software. This approach is used to measure the relationship between latent variables that affect satisfaction, effectiveness, transparency, and accuracy of the E-Procurement system. The study population involved 30 people in the Supply Chain Management Division of the Head Office, with data collected through an online questionnaire using Google Form. The results showed that the use of E-Procurement can significantly reduce procurement costs and time, with a T-statistic value of 5.558 (> 1.96) and P < 0.05. However, this system does not increase transparency because its effect is not significant with a T-statistic value of 0.069 (<1.96). In addition, the implementation of E-Procurement also did not improve the accuracy of the procurement process, as indicated by the T-statistic value of 0.035 (<1.96). The main obstacles to implementation include limited user understanding, inadequate instructions, and poor data quality. This study concludes that although E-Procurement has the potential to improve efficiency, additional efforts such as intensive training, regulatory improvements, and better data management are needed to support its overall success.
THE EFFECT OF OZONE TREATMENT ON THE CONTAMINATION OF WINTER WHEAT GRAINS WITH MYCOFLORA
Authors:   Voronezh State Agrarian University named after Emperor Peter the Great, Baskakov Ivan , Golovin Anton ,   Voronezh State Agrarian University named after Emperor Peter the Great, Pozhidaev Ilya ,   Voronezh State Agrarian University named after Emperor Peter the Great, Orobinsky Vladimir ,   Voronezh State Agrarian University named after Emperor Peter the Great, Khimchenko Arkady ,   Voronezh State Agrarian University named after Emperor Peter the Great, Semynina Tatiana ,   AllRussian Research Institute of Plant Protection, Gulevsky Vyacheslav ,   AllRussian Research Institute of Plant Protection
Published: December 2024

The article presents studies of the effect of ozone treatment on the contamination of grain
with mycophlora. The condition of grain during storage is analyzed. It was revealed that modern means
of disinfection of granaries do not provide suppression of mycophlora. Fungi of the genera Aspergillus,
Penicillium, Rhizopus and others were found in grain stored in elevators. Pathogens in the process of
vital activity produce mycotoxins, which remain inside the grain for a long time, poisoning it. With an
increase in the shelf life of grain, the number of fungal colonies without disinfection increases. Ozone
treatment at an ozone dose of over 28800 min·mg/m3
effectively suppresses pathogenic mycophlora, and
at a dose of 376000 min·mg/m3
reduces the toxicity of grain. However, the weak link of these studies is
the excessive concentration of ozone, which is very dangerous for humans. Since there is an aftereffect
effect of gas exposure on fungal cells that do not restore their functions after surgery and subsequently
die, there are prerequisites for the use of more gentle ozonation regimes that will ensure the disinfection
of grain with sufficient efficiency and safety. As a result of laboratory studies, it was found that with an
initial infection of grain with fungi of the genus Helminthosporium, 9.75% of the ozone dose of
7200 min·mg/m3
is sufficient to destroy more than half of these pathogens. Fungi of the genera Alternaria
and Fusarium turned out to be less susceptible to ozone. With an initial grain contamination of 22.5 and
11%, respectively, an ozone dose of 7200 min·mg/m3
allowed to suppress this infection by only a third.
Statistical analysis of the effectiveness of ozone treatment from the ozone dose allowed us to establish an
ozonation regime in which the pathogens under study will be completely destroyed. At these levels of
grain contamination, in order to suppress fungi of the genus Helminthosporium, the required dose of
ozone should exceed the values 9330 min·mg/m3
, fungi of the genera Alternaria and Fusarium – more
than 11350 min·mg/m3.
FORECASTING THE RESOURCE OF TWO-DISC COULTERS OF GRAIN SEEDERS
Authors:   Stavropol State Agrarian University, Notov Ruslan , Lebedev Anatoly ,   Kalmyk State University, Angrykov Boris ,   Kalmyk State University, Abushinov Oleg ,   Kalmyk State University, Badmaeva Tamara ,   Kalmyk State University, Lebedev Pavel ,   Stavropol State Agrarian University
Published: December 2024

The service life of the working bodies of soil-cultivating machines depends on the
properties of the processed environment. The influence of soil moisture on the change in its physical state
and wear capacity is analyzed. The factors of reduction and loss of performance of disc coulters of grain
seeders are established. It is proposed to assess the performance of disc coulters by the coulter
performance coefficient kрс. An analytical dependence of the kрс coefficient on the wear intensity in the
"normal" and "wear" periods is obtained. At kрс=0.25, the ratio of the "normal" and "wear" periods is
1:3. At kрс=0.75, this ratio is 3:1. An original experimental setup was created and studies of prototypes
on a loosely fixed abrasive were conducted. The highest wear resistance is demonstrated by the
experimental samples made of ultra-high molecular weight polyethylene (UHMWPE) grade PE-1000,
their relative wear is 0.29…0.44 compared to the sample made of 65G steel. Average wear rates for
different operating conditions were determined by field tests of the modernized (MDS) and standard
(SDS) disc coulters. They were 0.41 mm/ha and 0.25 mm/ha for the “normal” period and 1.92 mm/ha
and 1.62 mm/ha for the “wear” period of operation for SDS and MDS, respectively. A nomogram has
been developed for predicting the resource and monitoring the technical condition of double-disc coulters
for different operating conditions. With the value of kрс=0.25, the predicted resource for SDS will be
11.1 ha, against 16.2 for MDS. The resource increase is 1.46 times. With the value of kрс=0.75, the
predicted resource for SDS will be 23.1 ha, against 37.7 for MDS. The increase in the resource is 14.6
ha, which is 1.63 times more. The nomogram allows planning the implementation of repair and
restoration operations taking into account the actual annual load of grain seeders.
CADAVERIC STUDY ON RELATION OF EXTRACRANIAL COURSE OF FACIAL NERVE TO RETROMANDIBULAR VEIN
Authors: Davis Glory , Viswanath Namitha
Published: December 2024

Intimate knowledge of relation of facial nerve to retromandibular vein is vital in order to reduce the postoperative
morbidity related to facial nerve injury during surgery. The present study is a descriptive observational study done by
dissecting 50 cadavers (100 facial halves). The variations were documented and analysed. Retromandibular vein was related medial to facial
nerve in 100% cadavers. These variations in relation of facial nerve to retromandibular vein can explain the different consequences of facial nerve
injury, which may occur after various surgeries involving face. Therefore, knowledge of relation of facial nerve to retromandibular vein is
essential, if the nerve is to be preserved during surgery
APPROACHES TO OVERCOME THE ANTIBIOTIC RESISTANCE
Authors: Vishwakarma Vishal Kumar , Kaur Sukhpreet
Published: December 2024

Antibiotics are often described as the miracle drugs. They have made a significant impact, on healthcare by saving
countless lives each year. They represent a groundbreaking advancement in the field of science. However, the excessive
use and improper administration of antibiotics have resulted in the rise of bacteria that are resistant to these drugs. This poses a serious risk to
health. This article outlines the approaches used to overcome the issue of antibiotic resistance. The methods discussed include conducting
prescription audits to pinpoint and rectify prescribing mistakes for the use of antibiotics. The WHO standards and AWARE classification system
aim to standardize usage by encouraging evidence-based decisions and minimizing variations. Antibiotic stewardship initiatives are crucial, for
maximizing the effectiveness of antimicrobials to improve outcomes and combat resistance. The practice of time outs" entails reviewing therapy
every 48 to 72 hours to confirm its requirement and prevent misuse. Prior approval processes guarantee that treatments are deemed essential
before being approved to prevent use effectively. Enforcing limitations, around the availability of, over the counter antibiotics helps ensure that
these drugs are only utilized under the supervision of professionals to deter self-medication and misuse. Lastly increasing knowledge through
initiatives highlights the significance of following prescriptions diligently and comprehending the dangers associated with improper usage. This
thorough strategy emphasizes the significance of using antibiotics and monitoring their usage consistently while also educating the public to
maintain the effectiveness of antibiotics and tackle resistance effectively for safeguard health and ensure the continued efficacy of antibiotics, for
future generations.
CASE SERIES: A REVIEW OF SOME RARE MANIFESTATIONS AND ASSOCIATIONS OF ANORECTAL MALFORMATIONS.
Authors: Ronya Rejum , Raju Likha , Pao Karan
Published: December 2024

Introduction: Anorectal malformation (ARM) is a spectrum disease which affect the distal rectum and anus and also the
urinary and/or genital systems with or without associated anomalies. Types of ARM decide the management and surgical
repair. We review several types of anorectal malformation with rare and unique presentation. Case presentation: We review 7 cases of anorectal
malformations with varied presentations operated at TRIHMS, Naharlagun, Arunachal Pradesh. Anorecta Discussion: l malformation is quite
common and many times they are associated with other congenital malformations. clinicians need to examine the ARM babies very closely to see
for fistulas, level and type of malformation and also for associated malformations. Conclusion:Based on our experience, we strongly recommend
a proper evaluation of any anorectal malformation patient for presence of other associated malformations.
ASSOCIATION BETWEEN SENSORINEURAL HEARING LOSS AND BENIGN THYROID NODULES: A CLINICAL STUDY
Authors: Kumar Sharma Prateek , Kumar Kanaujia Surendra , Srivastava Amrita , Prasad Priyadarshi Basudev , Kanawjia Preeti , Singh Shiroman
Published: December 2024

Background: Sensorineural hearing loss (SNHL) is linked with thyroid disorders, particularly hypothyroidism, due to
the crucial role of thyroid hormones in cochlear function. This study investigates the prevalence and severity of SNHL in
patients with benign thyroid nodules to explore the association between thyroid dysfunction and hearing loss. This study aims to Objectives:
investigate sensorineural hearing loss (SNHL) in patients with benign thyroid nodules, focusing on its association, severity, and correlation with
nodule chronicity. This longitudinal cohort study was conducted over 2 years in the ENT department o Methodology: f a tertiary care medical
college. A total of 150 patients with diagnosed benign thyroid nodules, aged 18-55 years, were included, alongside 150 age- and sex-matched
controls. Patients with a history of ototoxic drug use, chronic suppurative otitis media (CSOM), thyroid malignancy, or other causes of SNHL
were excluded. Comprehensive audiological evaluations and thyroid function assessments were performed at baseline and at six-month
intervals. Among the 150 patients, the female-to-male ratio was 3.5:1, with a majority (56%) from ur Results: ban areas. SNHL was present in
34% of patients, with a higher prevalence in hypothyroid individuals. The severity of SNHL ranged from mild to moderately severe, correlated
with the duration of thyroid disease. Follow-up evaluations showed that 30% of hypothyroid patients experienced hearing improvement after
thyroid replacement therapy. There is a significant association between benign thyroid nodules and SN Conclusion: HL, particularly in
hypothyroid patients. Regular auditory evaluations are recommended for patients with thyroid disorders to detect and manage hearing
impairment early. Further research is warranted to explore the mechanisms linking thyroid dysfunction and cochlear pathology
INTEGRATING AYURVEDIC RASAYANA IN GERIATRIC CARE: A HOLISTIC APPROACH TO HEALTHY AGING
Authors: S. Yadav Manishkumar , K Yadav Mithilesh Kumar
Published: December 2024

The aging population worldwide, particularly in India, poses significant challenges for healthcare systems, necessitating
effective and comprehensive strategies to enhance care for aging populations. This paper explores the potential of
Ayurvedic Rasayana, a rejuvenation therapy rooted in traditional Indian medicine, as a viable approach to address age-related health issues. With
projections indicating that older adults will constitute a significant portion of India's population by 2050, understanding the multifaceted nature of
aging is crucial. This study reviews the principles of Rasayana, its preventive and therapeutic applications, and the evidence supporting its
efficacy in improving health outcomes for the elderly. It highlights key Rasayana herbs and formulations that promote extended lifespan,
cognitive function, and overall well-being while emphasizing the importance of individualized treatment plans. Challenges in integrating
Ayurvedic practices with contemporary medical frameworks are also discussed. Ultimately, this paper advocates for a transdisciplinary approach
to care for aging populations, underscoring the need for collaboration between Ayurvedic practitioners and conventional healthcare providers to
optimize health outcomes for aging populations.
ROLE OF TRANSTHORACIC ECHOCARDIOGRAPHY IN EVALUATION OF CHILDREN PRESENTING WITH HEART MURMURS: ORIGINAL ARTICLE
Authors: Kumar Sachin
Published: December 2024

Heart murmurs are a frequent finding in paediatric clinical practice, often presenting a diagnostic dilemma. The challenge
lies in distinguishing between innocent and pathological murmurs, which has significant implications for management.
Transthoracic echocardiography, a non-invasive imaging modality, has emerged as a reliable tool in evaluating murmurs, offering detailed
insights into cardiac structure and function. This retrospective observational study evaluates the role of transthoracic echocardiography in
assessing murmurs among paediatric patients, analyzing data from 150 children (1 day to 10 years old) at a secondary care hospital of Aligarh
(U.P.) in India from November 2023 to November 2024. Transthoracic echocardiography demonstrated a sensitivity of 95.4% and specificity of
97.8% in differentiating pathological murmurs from innocent ones. Transthoracic echocardiography is an invaluable tool in evaluating paediatric
murmurs. It's integration into routine paediatric practice can enhance diagnostic accuracy, streamline management, and improve patient
outcomes.
NOT SO INNOCENT AS PORTRAYED: CILNIDIPINE- INDUCED PEDAL EDEMA—A CASE SERIES
Authors: Balakrishna Arjun Mallasandra , D G Shobha
Published: December 2024

Background: Cilnidipine, a dual calcium channel blocker, is increasingly prescribed for hypertension and related
cardiovascular conditions. However, peripheral edema is a known adverse effect associated with calcium channel
blockers, and its incidence with cilnidipine remains underreported. This case series aims to highlig Objective: ht the occurrence of pedal edema in
patients treated with cilnidipine, contributing to the understanding of its safety profile. We presen Observations: t six cases of patients who
developed pedal edema following the initiation of cilnidipine therapy. Clinical details, including demographics, medical history, dosage, duration
of treatment, and management strategies, were collected and analyzed. Among the six cases, all pati Results: ents were treated for hypertension.
The onset of pedal edema varied from two weeks to nine months after starting cilnidipine.All patients were otherwise stable with no signs of heart
failure or renal impairment. Cilnidipine was discontinued in five patients, leading to a resolution of edema within a maximum of 2 weeks, while
the remaining one continued therapy with dose adjustment, resulting in partial resolution of symptoms. Pedal edema can occur in Conclusion:
patients treated with cilnidipine, and awareness of this potential side effect is essential for clinicians. Although numerous individual case reports
exist on this topic, this is the first-ever case series to describe cilnidipine-induced pedal edema, underscoring the need for larger case-control
studies to further investigate this side effect
A STUDY OF LEFT VENTRICULAR FUNCTION IN CHRONIC KIDNEY DISEASE PATIENTS
Authors: R Shilpa. , Priya. P Valli Krishna
Published: December 2024

Aims: The prevalence of left ventricular abnormalities in people suffering from chronic kidney disease is largely unclear.
Thus, the aim of this study was, firstly, to evaluate Left Ventricular Function In CKD patients and to identify abnormal
systolic and diastolic function by echocardiography in an age-stratified population-based on sample size and analyse associated clinical
parameters. This is a Prospective observational study conducted on patients with CKD, irrespective Methods and results: of treatment in the
department of general medicine DR. Pinnamaneni Siddhartha Institute of Medical Sciences & Research Foundation, Vijayawada, from January
2021 to June 2022 with age inclusion criteria more then 18 yrs. Most subjects in the control group are in the age group of 41-50 years (35 %).
Most subjects were belonging to the stage 3 chronic kidney disease (50 %) with male predominance. Majority of subjects were with diastolic
dysfunction (76.19 %), followed by systolic dysfunction (19.04 %) and least with both systolic and diastolic dysfunction (4.76%). There was a
highly significant statistical difference in the subject distribution on the basis of stage of CKD vs. type Left Ventricular Dysfunction (p value:
0.001). Most subjects were suffering from diastolic dysfunction with no statistical difference in the subject distribution on the basis of stage of
CKD vs. severity of systolic dysfunction (p value: 0.185). There was a significant statistical difference in the subject distribution on the basis of
stage of CKD vs. stage of diastolic dysfunction (p value: 0.01). Most subjects were in stage II diastolic dysfunction. There was a highly
significant statistical difference between GFR values and LVD stages (p value: 0.001). Left ventricul Conclusion: ar diastolic dysfunction is
more significantly associated with the decline in eGFR than systolic dysfunction in CKD patients. This is found to occur at an earlier stage of
CKD, even without LVH. Thus diastolic dysfunction is a much better predictor for cardiovascular mortality. According to our study
observations, eGFR has a negative co-relation with LVD and there is a highly significant statistical difference between both. This emphasizes the
need for correction of not just hemodynamic factors but also the renal related factors. Echocardiography provides a simple, non-invasive
investigation that can identify even asymptomatic patients at an earlier stage of CKD. So, earlier screening of CKD patients for LV diastolic
dysfunction can be recommended.
A RARE PRESENTATION OF SMAS (SUPERIOR MESENTERIC ARTERY SYNDROME) SECONDARY TO DUODENAL ADENOCARCINOMA
Authors: Dixit Abhishek , Mathew Praveen , Y Kanni Prashant , Babu Chandra , B Naidu Sidhartha
Published: December 2024

Superior mesenteric artery (SMA) syndrome (also known as Wilkie's syndrome, cast syndrome is an obstruction of the
duodenum caused by extrinsic compression between the SMA and the aorta with median age of patients is 23 years old and
predominant in females over males with a ratio of 3:2. Patient early diagnosis is required for Because recurrent vomiting leads to aspiration
pneumonia or respiratory depression via metabolic alkalosis. The useful diagnostic modalities are computed tomography and ultrasonography,
The primary treatment is conservative, including postural change, gastroduodenal decompression, and nutrient management. If conservative
therapy fails, surgical treatment (i.e., laparoscopic duodenojejunostomy) is recommended. We are presenting a case of superior mesenteric artery
syndrome secondary to duodenal carcinoma
DESARDA TISSUE REPAIR VERSUS LICHTENSTEIN MESH REPAIR - A COMPARATIVE STUDY OF SURGICAL OUTCOMES IN PATIENTS OF INGUINAL HERNIA
Authors: J Gowda Thejas , R Shashanka , B Rajanna
Published: December 2024

BACKGROUND AND OBJECTIVES: The inguinal hernia is one of the most common problems in the world. An ideal
hernia repair is still elusive. Currently Lichtenstein mesh repair technique is widely followed for hernia repair. Desarda
technique of inguinal hernia repair was introduced in 2001 and is still not considered standard tissue based hernia repair technique. The aim of the
study was to compare the tissue based Desarda technique with standard Lichtenstein repair in treatment of primary inguinal hernia.
METHODS: 140 cases were allocated into 2 groups. Desarda (D Group) had 70 and Lichtenstein (M Group) had 70 patients. Primary outcome
factors included operative time measured from skin incision to skin closure. Post operative pain scores was assessed on day using visual
analogue scale. Duration of hospital stay was noted, hematoma, seroma, surgical site infections,foreign body sensation etc. were evaluated as
postoperative complications. Patients were followed up regularly for a maximum period of 22 months. Early recurrence and chronic groin pain
was assessed at 6 months. Mean age in desarda's group 53.61 years while Lichtenstein group was 52.1 RESULTS: years .The mean duration of
surgery 34.6 min(D) vs 36.86 min(M). Duration of hospital stay was similar in both arms. There was no statistical difference in post operative
pain reduction at 9 months however patients in Desarda repair arm had reduction in pain more earlier than mesh repair group. Statistical
difference was seen in post operative infection as mesh removal was done in 14 patients in Lichtenstein group. After 22 month mean follow up
period no recurrence was noted in each arm . On comparison of Desarda technique with standard Licht CONCLUSION: enstein repair. Desarda
technique does not use a mesh thus do not have a component of mesh infection. Patients after Desarda's operative procedure gets normal activity
sooner as compared to the standard Lichtenstein mesh repair. We also found the use of Desarda technique in patients with inguinal hernia is a
technically sound option than Lichtenstein technique.
ADENOID CYSTIC CARCINOMA OF MAXILLARY SINUS:A RARE CASE REPORT
Authors: G. Velip Gaurangi , Souza Rocha Premila De , Naik Talaulikar Samiksha , Vernekar Sunidhi , Ghadi Amonkar Shubhra S.
Published: December 2024

Adenoid Cystic Carcinoma of the maxillary sinus is a rare tumour. It is a slow growing,aggressive,with high rates of local
and distal recurrence with a overall poor prognosis[1].Thus causing a considerable diagnostic challenge since the
symptoms mimic more common ailments such as sinusitis or allergic rhinitis,particularly in the early stage.We report a case of a 35 year old female
who presented to opd with proptosis and facial swelling.The clinical,radiological and histopathological examination found a mass compatible with
adenoid cystic carcinoma of maxillary sinus.
The Impact of Prenatal Birthing Ball Exercises on First Stage Labor Progression
Authors: Afroz Dr. Fahima , Naz Dr. Mah Zabin , Akhter Dr. Khaleda , Ahmed Dr. Tanjina , Siddika Dr. Ayesha
Published: December 2024

Background: Labor is a significant physiological event in a woman’s life, and its progression can vary greatly across individuals. Factors such as maternal health, fetal positioning, and interventions can influence the pace of labor. Among the strategies to support labor progression, prenatal birthing ball exercises have been increasingly used, with claims of enhancing pelvic flexibility, promoting better fetal positioning, and facilitating cervical dilation, potentially leading to smoother labor and delivery. Objective: This study aims to evaluate the impact of prenatal birthing ball exercises on the progression of the first stage of labor. Methods: This prospective study was conducted at Ahsania Mission Medical College and Cancer & General Hospital over one year, with 47 participants selected based on inclusion criteria. Participants received 3-6 birthing ball exercise sessions between 36-40 weeks of gestation. Data were collected on demographics, obstetric history, labor progression, pain assessment, and delivery outcomes. Statistical analysis, including t-tests, ANOVA, and chi-square tests, was used to analyze the data. Results: The majority of participants were young (18-29 years old), with most having secondary education and residing in urban areas. A significant portion was primigravida (64%), and 100% of participants performed birthing ball exercises. Pain experiences during labor varied, with most participants reporting moderate pain. Labor progression was mostly normal, with 66% experiencing vaginal deliveries. All participants showed normal fetal molding, and 88% had clear amniotic fluid. Conclusion: Prenatal birthing ball exercises appear to have a positive impact on labor outcomes, contributing to normal fetal molding and a higher rate of vaginal deliveries. The study suggests that these exercises may aid in labor progression and maternal comfort, though further research with larger sample sizes is needed to confirm these findings.
Effectiveness of Low-Dose Tamoxifen for Managing Ocular Manifestations in Breast Cancer Patients
Authors: Majumder Dr. Rumana Afroz , Arman Dr. Kazi Abdullah
Published: December 2024

Background: Breast cancer remains one of the most common malignancies worldwide, with hormonal therapies like tamoxifen significantly improving survival rates in hormone receptor-positive cases. However, tamoxifen’s systemic effects can lead to adverse outcomes, including ocular manifestations such as cataracts, retinopathy, and optic neuritis. These complications, although rare, may impact quality of life, prompting a focus on low-dose tamoxifen to mitigate risks while preserving efficacy. Objective: This study evaluates the ocular outcomes of low-dose tamoxifen in breast cancer patients, aiming to explore its safety and implications for long-term therapy. Methods: A longitudinal study was conducted at Dhaka Medical College Hospital between October 2019 and July 2020. Sixty breast cancer patients treated with low-dose tamoxifen for more than two years were evaluated through detailed ophthalmic examinations, including visual acuity tests, slit lamp biomicroscopy, color fundus photography (CFP), and optical coherence tomography (OCT). Data were analyzed using SPSS software. Results: Among the participants, 11.1% (n=5) exhibited ocular manifestations, including cataracts (6.7%), retinitis (2.2%), and optic neuritis (2.2%). These complications were associated with extended tamoxifen therapy (27–33 months). The findings suggest a correlation between prolonged tamoxifen use and ocular toxicity, although the prevalence was relatively low. Conclusion: Low-dose tamoxifen was associated with minimal ocular side effects, supporting its viability as a safer alternative for long-term therapy in breast cancer patients. Comprehensive ophthalmic evaluation before and during treatment is recommended to ensure early detection and management of potential complications.
A Study on Clinical Status of Urothelial Carcinoma in Bangladesh
Authors: Haque Dr. Sharmin , Saleh Dr. Suporna , Akter Dr. MST Rommana , Afrin Dr. Syeda Sadia , Shaheen Dr. Nazma
Published: December 2024

Background: Urothelial carcinoma, a predominant malignancy of the bladder, represents a growing public health concern in Bangladesh due to environmental and lifestyle factors, including tobacco use and arsenic exposure. Limited healthcare infrastructure and delayed diagnosis exacerbate the burden, emphasizing the need for region-specific research. Objective: To evaluate the demographic, clinical, and pathological characteristics of urothelial carcinoma in a Bangladeshi population. Methods: This descriptive cross-sectional study was conducted at Dhaka Medical College from January 2016 to December 2017. Fifty histologically confirmed bladder cancer cases were analyzed based on clinical and demographic profiles, tumor grading, and pathological extent. Data were collected systematically using a pre-designed pro forma, and histopathological and immunohistochemical analyses were performed. Statistical analysis was conducted using SPSS. Results: The majority (58.0%) of patients were ≤60 years, with a mean age of 60.9 ± 13.1 years, and males constituted 80.0% of cases. Most patients (72.0%) had a history of smoking and betel nut chewing, with hematuria (100.0%) and anemia (100.0%) being the most common clinical features. Tumors were predominantly confined to PT1 (68.0%), with high-grade tumors showing a greater likelihood of PT2 extension (38.9%). Smoking and tumor grade were not statistically significantly associated (p = 0.517). Conclusion: The study highlights the high prevalence of urothelial carcinoma in males, its association with modifiable risk factors, and the predominance of non-muscle-invasive tumors. These findings underscore the urgent need for public health interventions targeting risk factors, early detection, and accessible treatment options tailored to the Bangladeshi context.
Application of AI Algorithms for the Prediction of the Likelihood of Sickle Cell Crises
Authors: Okon Essang Samuel , Michael Kolawole Olamide , Friday Runyi Emmanuel , Efiong Ante Jackson , Obi Ogar-Abang Micheal , Timothy Auta Jonathan , Edet Okon Paul , Dominic Effiong Raphael , Jimmy Ukim Akanimo
Published: December 2024

This paper investigates the application of Support Vector Machines (SVM), Random forest and Logistic Regression as AI algorithms to predict the likelihood of sickle cell crises. The study focused on the various considerations involved in utilizing SVMs, Random forest and Logistic Regression for this predictive task, encompassing feature selection, data quality assessment, handling class imbalance, model training, hyper parameter optimization, evaluation metrics, and interpretability. Special attention is given to addressing the complexities of Sickle Cell Disease data and ensuring the reliability of predictions. Through a comprehensive analysis, we accentuate the relevance of SVMs, Random forest and Logistic Regression in capturing intricate relationships within high-dimensional SCD datasets. It emphasizes the importance of feature selection, particularly in integrating genetic markers, clinical parameters, and environmental factors, to enhance prediction accuracy. Also, we highlight the significance of model interpretability in healthcare applications, enabling clinicians to understand the rationale behind predictions and facilitating informed decision-making. Validation and testing procedures are highlighted as crucial steps to ensure the generalizability and robustness of the SVM, Random Forest and Logistic Regression-based predictive model in real-world clinical settings. Finally, leveraging Support Vector Machines and other machine learning algorithms for predicting sickle cell crises likelihood offers promising avenues for proactive management and personalized care strategies. By harnessing AI algorithms effectively, healthcare practitioners can enhance patient outcomes through timely interventions tailored to individual risk profiles. However, further research and validation efforts are warranted to maximize the clinical utility and reliability of SVM, Random forest and Logistic Regression -based predictive models in SCD management.
Impact of Cloud ERP on Quality of Financial Reports in Indonesia
Authors: Shafa Nadhira Indah Hasna , Hasnawati Hasnawati
Published: December 2024

Penelitian ini menguji pengaruh faktor Cloud ERP terhadap quality of financial reports. Cloud ERP diukur menggunakan karakteristik cloud computing dengan 5 (lima) variabel yaitu on demand self-service, broad network access, resource pooling, rapid elasticity, dan measured serviced. Untuk quality of financial report dengan karakteristik understandbility, comparability, relevance, dan realibility menggunakan metode kuantitatif dan menerapkan teknik purposive sampling. Penelitian ini bertujuan untuk menganalisis pengaruh karakteristik Cloud ERP terhadap kualitas laporan keuangan di perusahaan-perusahaan di Indonesia.Data penelitian ini diperoleh dengan menggunakan kuisiooner berupa google form dan disebar melalui jaringan pertemanan LinkedIn, Instagram, dan Facebook dan di isi sebanyak 97 google form. Jawaban yang memenuhi syarat untuk diolah berjumlah 60 responden. Data diolah menggunakan SPSS 25 dengan regresi berganda. Hasil penelitian ini menunjukan bahwa secara simultan cloud erp berpengaruh terhadap quality of financial report. Kemudian, secara parsial broad network access, rapid elasticity, dan measured service memiliki pengaruh terhadap quality of financial report. Sedangkan, on demand self-service dan resource pooling tidak berpengaruh terhadap quality of financial report. Studi merekomdendasikan perlunya organisasi lebih mengupayakan, mempersiapkan, dan menyedikan pelatihan khusus bagi pemakainya mengenai topik cloud erp.
Strategi Komunikasi Keberlanjutan untuk Membangun Stakeholder Engagement pada Ekowisata Mangrove
Authors: Irmayanti Dian , Sri Ekomurtiningsih Bertha , Rusdianto Berto Agustinus
Published: December 2024

Provinsi Banten memiliki potensi mangrove sangat besar. Salah satunya adalah hutan mangrove yang berada di desa patikang, yang sedang dikembangkan menjadi Program Pengembangan Edu-Ekowisata Lembur Mangrove Patikang. Namun, Perbedaan kepentingan dan tujuan di antara para pemangku kepentingan dapat mempersulit pengambilan keputusan dan implementasi, sehingga menekankan perlunya dialog dan negosiasi yang terbuka. Penelitian ini bertujuan untuk mengetahui strategi komunikasi keberlanjutan untuk membangun stakeholder engagement. Penelitian ini menggunakan penelitian kualitatif dengan paradigma post-positivisme dan metode studi kasus Tunggal. dengan Pemilihan informan dilakukan dengan metode purposive sampling. Penelitian ini menggunakan teknik keabsahan triangulasi data, dan teknik analisis data menggunakan pencocokan pola. Dalam konteks pengembangan pariwisata berkelanjutan, strategi komunikasi keberlanjutan memainkan peran yang sangat penting dalam membangun keterlibatan stakeholder. Strategi communication for sustainability menekankan pentingnya komunikasi yang terintegrasi dan partisipatif. Pendekatan ini mendorong keterlibatan aktif dari semua pemangku kepentingan dalam proses komunikasi, sehingga menciptakan dialog yang konstruktif dan saling menghargai. Kolaborasi model komunikasi hypercube menawarkan perspektif multidimensional dalam memahami interaksi antara berbagai elemen komunikasi.
Impact if Lagging Region Status on Education in Indonesia
Authors: Negara Gadis Mahkota
Published: December 2024

Place-based policies are commonly used in developing countries to stimulate economic development in underdeveloped regions. One such policy implemented by the Indonesian government, spanning from the presidency of SBY to Jokowi, involves designating certain districts as “lagging regions.” This study examines the impact of this designation on education during these two administrations, utilizing panel data from 2003 to 2018 across 514 districts in Indonesia. The analysis is divided into three periods, corresponding to different phases of the policy’s implementation. The education indicator used is the net enrollment ratio, with the special allocation fund (DAK) serving as the mediating variable. The findings are consistent across various empirical approaches, including propensity score matching, first difference, and panel data estimation. Despite these efforts, the designated lagging regions still have a lower net enrolment ratio than the non-lagging regions. The overall results suggest that there has been no convergence in the educational outcomes between the two groups of regions. This highlights the need for adequate resource mobilization to ensure the effectiveness of such place-based policies.
Pengaruh Karakteristik Dewan Terhadap Manajemen Laba Dengan Ukuran Perusahaan Sebagai Variabel Moderasi
Authors: Dila Wahidah Rizky , Christian Natalis
Published: December 2024

Tujuan dari penelitian ini adalah untuk menguji bagaimana faktor-faktor seperti ukuran dewan direksi, keragaman gender, independensi, dan pengetahuan keuangan mempengaruhi metode manajemen laba. Penelitian ini menyelidiki pengaruh karakteristik dewan, yaitu ukuran dewan, independensi dewan, diversitas gender dewan, dan keahlian keuangan dewan, terhadap praktik manajemen laba dalam perusahaan. Selain itu, penelitian ini juga meneliti peran moderasi ukuran perusahaan serta efek kontrol usia perusahaan dan kinerja perusahaan. Penelitian ini menerapkan analisis regresi panel untuk menentukan hubungan antara variabel-variabel tersebut. Studi kasus dilakukan pada perusahaan. Dari tahun 2018 hingga 2022, terdapat 450 perusahaan berbeda yang dimasukkan dalam sampel, yang semuanya terdaftar di Bursa Efek Indonesia (BEI). Kami menggunakan analisis regresi data panel untuk melihat data. Hasil penelitian membuktikan bahwa manajemen laba tidak mampu diberi pengaruh oleh ukuran dewan direksi. Manajemen laba tidak mampu diberi pengaruh oleh ukuran dewan direksi independen. Manajemen laba mampu diberi pengaruh secara negatif oleh ukuran dewan ahli keuangan. Manajemen laba mampu diberi pengaruh secara positif oleh ukuran dewan direksi wanita. Manajemen laba tidak mampu diberi pengaruh oleh ukuran perusahaan. Manajemen laba tidak mampu diberi pengaruh oleh ukuran dewan direksi dan ukuran dewan independen yang dimoderasi oleh ukuran perusahaan, namun manajemen laba mampu diberi pengaruh oleh keberagaman gender dan dewan keahlian keuangan yang dimoderasi oleh ukuran perusahaan.
Tahapan Implementasi Agile Software Development Area Quality di Bio Farma
Authors: Oktoveri Adeva
Published: December 2024

Penelitian ini bertujuan untuk mengeksplorasi dan merancang tahapan implementasi metode Agile Software Development (ASD) di area kualitas Bio Farma yang memiliki tingkat regulasi tinggi dalam sektor farmasi. Dalam satu dekade terakhir, transformasi digital menjadi topik yang selalu menarik untuk dibahas dan banyak perusahaan yang mulai melakukan hal tersebut. Dalam prakteknya, untuk melakukan transformasi digital di perusahaan masing-masing, perusahaan di Indonesia mulai menggunakan konsep pengembangan sistem digital berbasis Agile Software Development / Pengembangan Perangkat Lunak dengan cara yang tangkas. Pendekatan yang digunakan dalam penelitian ini adalah kualitatif. Hasil penelitian ini adlaah kondisi Bio Farma saat ini menunjukkan bahwa tim IT secara umum cukup siap dalam budaya dan kebiasaannya saat ini untuk mengimplementasikan metode agile, meskipun masih banyak ruang untuk improvement. Tahapan yang perlu dilakukan oleh Bio Farma untuk implementasi metode agile dalam proses pengembangan perangkat lunak di area quality terdiri dari lima tahapan yang perlu dilakukan oleh Bio Farma untuk menerapkan ASD di area quality, yaitu:1) menyusun tim change management, 2) merekrut Subject Matter Expert (SME), 3) menyelenggarakan training metode agile, 4) menganalisis metode agile yang tepat di Bio Farma, dan 5) menyesuaikan SOP pengembangan dan validasi aplikasi sesuai dengan motode agile yang sesuai.
Development of a Multimedia Dance Teaching Module to Enhance the Competence of Fifth Grade Elementary School Teachers in DKI Jakarta
Authors: Indriani Henny , Puryati Puryati , Suroyo Suroyo
Published: December 2024

Penelitian ini bertujuan untuk mengembangkan modul pengajaran tari multimedia untuk meningkatkan kompetensi guru kelas lima di sekolah dasar di DKI Jakarta. Metode penelitian menggunakan pendekatan penelitian dan pengembangan yang dikembangkan oleh Borg dan Gall. Penilaian ahli melibatkan dosen dari Universitas Negeri Jakarta. Subjek penelitian adalah guru dan siswa dari sekolah-sekolah di DKI Jakarta. Teknik pengumpulan data meliputi kuesioner dan diskusi kelompok terfokus (FGD). Teknik analisis data dilakukan dengan menggunakan metode campuran, di mana data kuantitatif dianalisis menggunakan statistik nonparametrik dan data kualitatif dideskripsikan untuk mendukung data kuantitatif. Kemampuan guru untuk mengajarkan materi tari sangat penting bagi siswa untuk tidak hanya memperoleh keterampilan menari tetapi juga untuk menghargai tarian. Hasil penelitian menunjukkan bahwa modul pengajaran secara signifikan membantu guru dalam memahami materi tari. Dapat disimpulkan bahwa kemampuan guru dalam proses pembelajaran diperoleh melalui modul pengajaran tari multimedia. Disarankan agar modul tari multimedia dapat digunakan sebagai alternatif sumber belajar bagi guru.
The Effect of Hordeum Vulgare on Spermatogenesis and Testical Histopathology in Diabetes Mellitus Rats
Authors: Eka Putri Sihombing Clarisa , Indra Mukti Ade , Edlin Edlin
Published: December 2024

Diabetes dapat memicu kerusakan pada sistem reproduksi pria dan merupakan salah satu faktor penyebab infertilitas pada pria. Tujuan dari penelitian ini adalah untuk menguji pengaruh Hordeum vulgare terhadap spermatogenesis pada tikus diabetes. Penelitian ini menggunakan desain penelitian True Experimental Pretest dan Posttest Control Group Design. Sampel tikus adalah tikus Wistar jantan (Rattus norvegicus), dengan berat sekitar 200 gram, dan berusia sekitar 2 bulan. Variabel independen dalam penelitian ini adalah Hordeum vulgare dan variabel dependennya adalah motilitas sperma dan ciri-ciri histopatologis testis tikus. Data akan diolah menggunakan uji Kruskal Wallis dengan SPSS. Hasil penelitian menunjukkan bahwa tidak ada perbedaan yang signifikan dalam spermatogenesis tikus antar kelompok. Pengaruh Hordeum vulgare pada skor rata-rata Johnsen dan gambaran histopatologis testis tikus diabetes menunjukkan bahwa kelompok tikus diabetes yang diberi makan Hordeum vulgare memiliki banyak spermatozoa tetapi epitel germinal tidak teratur yang ditandai dengan exfol.
Advancements in Turning: Exploring Hybrid Nanofluids and MQL Strategies
Authors: M Karthikraja , P Kalidoss , S Anbu , P Prabakaran
Published: December 2024

This research examines hybrid nanofluids in turning operations using Minimum Quantity Lubrication (MQL), a popular method for improving machining efficiency and sustainability. Hybrid nanofluids have better thermal conductivity, heat transfer, and lubrication than conventional coolants and single-component options. Using hybrid nanofluids with MQL can reduce cutting temperatures, improve surface polish, lengthen tool life, and reduce environmental impact while enhancing material removal rate and coefficient of friction. This research covers recently developed hybrid nanofluid selection criteria, MQL parameter modification, and turning process performance enhancements. Stability, cost, and health hazards are also discussed while using hybrid nanofluids in industry. The data suggest that formulations and deployment techniques require more investigation to ensure widespread acceptance of this promising technology in modern production.