bluuebunny/crossref_metadata_2025 huggingface dataset:
Non-invasive identification of paint binders in illuminated manuscripts by ER-FTIR spectroscopy: a systematic study of the influence of different pigments on the binders’ characteristic spectral features
Authors: Nodari Luca , Ricciardi Paola
Published: February 2019

This paper presents the results of a study of pigment-binder systems painted on parchment, both in the form of reference samples prepared in the laboratory, and of medieval and Renaissance illuminated manuscripts, by means of contactless Fourier-transform mid-infrared spectroscopy (FTIR). The research is aimed at validating external reflection FTIR (ER-FTIR) as a non-invasive method for the identification of paint binders in works of art on parchment. Based on a systematic FTIR investigation undertaken both in attenuated total reflection (ATR) and ER mode, we discuss the possibility to effectively discriminate between different binders, and the way in which the presence of a number of pigments can modify the spectral features of the pigment-binder system. The study reveals that gum Arabic can usually be discriminated from egg-based binders such as egg yolk and egg white, both in paintouts and in real artworks. Amongst all the pigments investigated, carbonates such as azurite and lead white are those that most significantly hinder the correct identification of the paint medium.
Multicenter Trial of [18F]fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Staging of Head and Neck Cancer and Negative Predictive Value and Surgical Impact in the N0 Neck: Results From ACRIN 6685
Authors: Lowe Val J. , Duan Fenghai , Subramaniam Rathan M. , Sicks JoRean D. , Romanoff Justin , Bartel Twyla , Yu Jian Q. (Michael) , Nussenbaum Brian , Richmon Jeremy , Arnold Charles D. , Cognetti David , Stack Brendan C.
Published: February 2019

PURPOSE

The objective of this study was to determine the negative predictive value (NPV) of positron emission tomography (PET)/computed tomography (CT) for the clinically N0 neck on the basis of neck dissection.

METHODS

Participants with newly diagnosed, first-time, head and neck squamous cell carcinoma (HNSCC) and at least one clinically N0 neck side for which dissection was planned were included. A total of 287 participants were prospectively enrolled from 23 American College of Radiology Imaging Network-qualified institutions. PET/CT was compared with findings at neck dissection.

RESULTS

PET/CT scans and pathology findings were available for 270 N0 neck sides from 212 participants. For visual assessment, the NPV specific to the clinical-N0 sides was 0.868 (95% CI, 0.803 to 0.925). For dichotomized maximum standardized uptake value, the NPVs specific to the nodal basins were 0.940 (95% CI, 0.928 to 0.952) and 0.937 (95% CI, 0.925 to 0.949) at prespecified cutoffs of 2.5 and 3.5, respectively. The optimal cutoff maximum standardized uptake value was determined to be 1.8, with an NPV of 0.942 (95% CI, 0.930 to 0.953). The PET/CT-informed surgical treatment plan was changed in 51 of 237 participants (22%) compared with the PET/CT-blinded surgical plan. In 34 participants (14%), this led to planned dissection of additional nodal levels. In 12 participants (5%), this led to fewer planned dissected nodal levels. Negative PET/CT scans in N0 necks was true negative in 87% and false negative in 13%.

CONCLUSION

[18F]fluorodeoxyglucose-PET/CT has high NPV for the N0 neck in T2 to T4 HNSCC. The surgical treatment plans on the basis of PET/CT findings may be changed in approximately 22% of this group. These findings suggest that [18F]fluorodeoxyglucose-PET/CT may assist the clinician in deciding on the best therapy for the clinically N0 neck in HNSCC. Well-designed clinical trials should be performed to test the outcome of omitting neck dissection by using PET/CT.
Fibroblast Growth Factor 21, Adiponectin, and Irisin as Markers of Unfavorable Metabolic Features in 12-Year-Old Children
Authors: Seppä Satu , Tenhola Sirpa , Voutilainen Raimo
Published: February 2019

Context

Among cytokines, fibroblast growth factor 21 (FGF21), adiponectin (Adn), and irisin have been considered potential biomarkers for insulin sensitivity (IS).

Objective

We evaluated whether serum FGF21, Adn, and irisin associate with markers of IS and serum lipids in 12-year-old children.

Design, Participants, and Main Outcome Measures

This cohort study included 192 12-year-old children (109 girls). Seventy-eight of them had been born appropriate for gestational age (AGA), 70 small for gestational age (SGA), and 44 from preeclamptic pregnancies (PREs) as AGA. Fasting serum FGF21, Adn, irisin, lipids, inflammatory markers, and IS markers were measured. Quantitative insulin sensitivity check index (QUICKI) was calculated.

Results

The means of serum FGF21, high molecular weight (HMW) Adn, and irisin did not differ between the sexes or between the SGA, AGA, and PRE children. In the whole study population, FGF21 associated positively with irisin and uric acid and negatively with leptin and high-density lipoprotein cholesterol (HDL-C). HMW Adn associated positively with total Adn, HDL-C, leptin, and SHBG. Apart from FGF21, irisin associated positively with insulin, high-sensitivity C-reactive protein, γ-glutamyltransferase, and triglycerides, and negatively with QUICKI, SHBG, and IGF binding protein-1. In multivariate regression analyses, irisin predicted lower IS and HMW Adn predicted higher HDL-C body mass index-independently, whereas FGF21 had no independent contribution to IS or lipid variables.

Conclusion

In 12-year-old children, serum irisin was associated with markers reflecting reduced IS. HMW Adn predicted HDL-C, whereas FGF21 did not contribute to IS or lipid parameters in multivariate regression analyses.
The unfolded protein response in metazoan development
Authors: Mitra Sahana , Ryoo Hyung Don
Published: February 2019

Eukaryotic cells respond to an overload of unfolded proteins in the endoplasmic reticulum (ER) by activating signaling pathways that are referred to as the unfolded protein response (UPR). Much UPR research has been conducted in cultured cells that exhibit no baseline UPR activity until they are challenged by ER stress initiated by chemicals or mutant proteins. At the same time, many genes that mediate UPR signaling are essential for the development of organisms ranging from Drosophila and fish to mice and humans, indicating that there is physiological ER stress that requires UPR in normally developing animal tissues. Recent studies have elucidated the tissue-specific roles of all three branches of UPR in distinct developing tissues of Drosophila, fish and mammals. As discussed in this Review, these studies not only reveal the physiological functions of the UPR pathways but also highlight a surprising degree of specificity associated with each UPR branch in development.
Meeting report – Building the Cell 2018
Authors: Bertin Aurelie , Lomakin Alexis
Published: February 2019

Cell biologists from all around the world gathered in Paris on the 26 to 28 September 2018 to participate in the 3rd international meeting ‘Building the Cell’. It was organized by Hélène Barelli, Arnaud Echard, Thierry Galli, Florence Niedergang, Manuel Théry and Marie Hélène Verlhac on behalf of the French Society for Cell Biology (SBCF) at the Institut Pasteur. Around 230 participants joined the meeting for stimulating talks, discussions, poster sessions, and a gala dinner on the Seine that included a music performance by the rock group ‘Membrane Band’. The unifying theme of the meeting was the development of creative multidisciplinary approaches to understand cellular life at different scales in a dynamic and quantitative manner. Here, we summarize the results presented at the meeting and the emerging ideas from the different sessions.
A curated transcriptome dataset collection to investigate inborn errors of immunity
Authors: Bougarn Salim , Boughorbel Sabri , Chaussabel Damien , Marr Nico
Published: February 2019

Primary immunodeficiencies (PIDs) are a heterogeneous group of inherited disorders, frequently caused by loss-of-function and less commonly by gain-of-function mutations, which can result in susceptibility to a broad or a very narrow range of infections but also in inflammatory, allergic or malignant diseases. Owing to the wide range in clinical manifestations and variability in penetrance and expressivity, there is an urgent need to better understand the underlying molecular, cellular and immunological phenotypes in PID patients in order to improve clinical diagnosis and management. Here we have compiled a manually curated collection of public transcriptome datasets mainly obtained from human whole blood, peripheral blood mononuclear cells (PBMCs) or fibroblasts of patients with PIDs and of control subjects for subsequent meta-analysis, query and interpretation. A total of nineteen (19) datasets derived from studies of PID patients were identified and retrieved from the NCBI Gene Expression Omnibus (GEO) database and loaded in GXB, a custom web application designed for interactive query and visualization of integrated large-scale data. The dataset collection includes samples from well characterized PID patients that were stimulated ex vivo under a variety of conditions to assess the molecular consequences of the underlying, naturally occurring gene defects on a genome-wide scale. Multiple sample groupings and rank lists were generated to facilitate comparisons of the transcriptional responses between different PID patients and control subjects. The GXB tool enables browsing of a single transcript across studies, thereby providing new perspectives on the role of a given molecule across biological systems and PID patients. This dataset collection is available at http://pid.gxbsidra.org/dm3/geneBrowser/list.
Case Report: Levetiracetam causing acute liver failure complicating post-operative management in a neurosurgical patient
Authors: Jayashankar Sharanya , Munakomi Sunil , Sayeerajan Vignesh , Kafle Prakash , Chaudhary Pramod , Thingujam Jagdishchandra , Poudel Deepak , Cherian Iype
Published: February 2019

Background: Herein we report a rare case of acute liver failure due to levetiracetam, which has been considered to have an excellent safety profile with minimal hepatic side effects.

Case presentation: A 55-year-old male patient presenting with sudden onset dizziness, slurring of speech and headache was operated for posterior fossa cerebellar hematoma. His post-surgical period was complicated by development of icterus with elevation of liver enzymes. After ruling out common inciting factors, it was decided to stop levetiracetam which was given prophylactically for preventing seizures owing to presence of external ventricular drain. From the next day patient had dramatic improvement in liver functions and sensorium.

Conclusions: We would like to highlight this side effect that is potentially life threatening, though rare, of levetiracetam, which is very commonly used in today’s practice and fast superseding all other time-tested antiepileptics.
Cryopreserved amniotic membrane and umbilical cord for a radiation-induced wound with exposed dura: a case report
Authors: Fernandez David
Published: February 2019

An 87-year old male received surgical excision of scalp melanoma and subsequent radiotherapy due to metastasis to the skull. A radiation-induced wound developed with osteoradionecrosis that required necrotic bone excision resulting in a 7.5x8.5cm wound over the exposed dura, which remained non-healing despite many attempts by local wound care management. Due to the refractory nature of the wound, strips of cryopreserved umbilical cord (cUC) allograft were applied over the exposed dura resulting in significant vascular granulation tissue formation in the central wound bed within four weeks. Re-epithelialisation around the wound perimeter was further promoted by injection of particulate amniotic membrane umbilical cord matrix (AMUC) at the 16th week, and completed by another application of cUC strips and injection of AMUC proximal to the necrotic bone at the 21st week. Vascularisation of the necrotic bone was further promoted by application of cUC and AMUC injection directly into the bony margins at 29 weeks and 34 weeks, respectively, followed by application with an AMUC-hydrogel paste, applied four times over an eight week interval. By 96 weeks, healthy re-epithelialised tissue had formed under the necrotic bony margins. This report highlights the unique regenerative capabilities of cUC and AMUC in promoting wound healing over exposed dura in a long-standing full-thickness, radiation-induced scalp and skull wound.
Spectroscopic and thermal degradation studies of novel hybrid polymer based on sodium polyphosphate - polystyrene
Authors: Driss Rair , Halima El Aadad , Touria Jermoumi , Abdelkrim Chahine
Published: February 2019

We have synthesized by the hydrophobic effect a new hybrid polymer material (HP) composed of segments of different solubility: polystyrene (hydrophobic) and sodium metaphosphate (hydrophilic). The structure and thermal stability of these hybrid materials were investigated and compared to the starting materials using X-ray diffraction (XRD), 31P Nuclear Magnetic Resonance, Raman spectroscopy and thermogravimetric analysis (TGA).The structure of the hybrid material consists of a mixture of phosphate compounds resulting from the hydrolysis of NaPO3. The phosphate groups have probably formed hydrogen bonds with aromatic CH. Furthermore, the delocalization of the electrons in the aromatic group generates negative poles that can interact with the positively charged Na ion, forming a cation-Ï€ interaction.The thermal characterization of these hybrids shows a clear improvement of the thermal property. TGA results show that phosphates increase HP residues yields at 600°C. Thus, Raman spectroscopy results provide evidence for the formation of residues having an aromatic phosphocarbon and an aromatic graphitic structure.
Increased Clinical Sensitivity and Specificity of Plasma Protein N-Glycan Profiling for Diagnosing Congenital Disorders of Glycosylation by Use of Flow Injection–Electrospray Ionization–Quadrupole Time-of-Flight Mass Spectrometry
Authors: Chen Jie , Li Xueli , Edmondson Andrew , Meyers Gail Ditewig , Izumi Kosuke , Ackermann Amanda M , Morava Eva , Ficicioglu Can , Bennett Michael J , He Miao
Published: February 2019

BACKGROUND

Congenital disorders of glycosylation (CDG) represent 1 of the largest groups of metabolic disorders with >130 subtypes identified to date. The majority of CDG subtypes are disorders of N-linked glycosylation, in which carbohydrate residues, namely, N-glycans, are posttranslationally linked to asparagine molecules in peptides. To improve the diagnostic capability for CDG, we developed and validated a plasma N-glycan assay using flow injection–electrospray ionization–quadrupole time-of-flight mass spectrometry.

METHODS

After PNGase F digestion of plasma glycoproteins, N-glycans were linked to a quinolone using a transient amine group at the reducing end, isolated by a hydrophilic interaction chromatography column, and then identified by accurate mass and quantified using a stable isotope-labeled glycopeptide as the internal standard.

RESULTS

This assay differed from other N-glycan profiling methods because it was free of any contamination from circulating free glycans and was semiquantitative. The low end of the detection range tested was at 63 nmol/L for disialo-biantennary N-glycan. The majority of N-glycans in normal plasma had <1% abundance. Abnormal N-glycan profiles from 19 patients with known diagnoses of 11 different CDG subtypes were generated, some of which had previously been reported to have normal N-linked protein glycosylation by carbohydrate-deficient transferrin analysis.

CONCLUSIONS

The clinical specificity and sensitivity of N-glycan analysis was much improved with this method. Additional CDGs can be diagnosed that would be missed by carbohydrate-deficient transferrin analysis. The assay provides novel biomarkers with diagnostic and potentially therapeutic significance.
CVCren ertzetako alternantziak eta aitzineuskararen hitz-familien azterketarako hatsarriak: "*ban/bar-/bal"-en zirriborroa / CVC-edge alternancies and the foundations of the analysis of Proto-Basque word families: An outline of "*ban/bar-/bal"
Authors: Lakarra Joseba
Published: February 2019

Mitxelenak erakutsi bezala, hitzen ezkerraldea da kokagunerik zailena berreraikitzeko orduan; horko hotsen artean, gainera, b- ez da arazo gutxien ematen duena, dituen aldaketa eta erorketa ugariengatik (*b- > b-, ø-, m-). Halaber, euskararen ISaren morfologia diakronikoan fenomeno zaharrenak (erreduplikazio eta aurrizkitzea) ezker izan arren, badira eskuin aldean zenbait txandakatze ilun (-n / -r / -ø; -r / -l) aspaldi antzemanak nahiz, orain arte, ondorio sakonik ez lortu eta ezta hain irregularitate garrantzitsuek merezi arta jaso ere. AEren berreraiketarako guztiz garrantzitsu da morfologia, fonologia eta etimologiaren oinarrian diren hitz-familiak ikertzen hastea eta horietarik baten (*ban/bar-/bal-en) zirriborroa aurkeztu nahi dugu, lan zabalago eta sakonagoen aurrerapen legez. Gaude, fonologia eta morfologia zaharrenaren geruzen eta kronologiaren ezagutzarako onurarik izan dezakegula bertan, zein bere aldetik tratatutako —edo oraindik horretara ere iritsi ez diren— 140 bat hitzen etimologiak argitzen edo argitzeko bidean jartzen laguntzeaz landa. *bon/bor-/bol- kidearen azterketa arinagoaz baliaturik egindako ohar eta iruzkinek sendotu egiten dituzte ikertutako familiaren analisian lortutako datu, azalpen eta ondorio nagusiak.
Development of Interactive Multimedia Learning to Improve Analytical Thinking Ability of Elementary School Student on Water Cycle Material
Authors: Azizah Hani Nur' , Rahayu Wardani , Cahyana Ucu
Published: February 2019

Development of interactive multimedia is an alternative solution for learning in elementary schools that are not optimally delivered through direct observation, more precise for science learning on water cycle material that has difficulty
delivered in the classroom to facilitate the achievement of basic competence that has the same achievement with 21st century competence that is analytical thinking ability. Based on this urgency, this research has a purpose to know the procedure of
developing interactive multimedia learning that can improve analytical thinking ability on the water cycle material and know the effectiveness of interactive multimedia developed to improve analytical thinking ability of the elementary student. The
method is research and development of Lee and Owens model (assessment and needs analysis, design, development and implementation, and evaluation). The research result was: (1) interactive multimedia learning to improve analytical thinking ability on
water cycle material reached standard on validation of three experts (material, media, and language) and four practitioners (all validators in each aspect or 100% validators approve interactive multimedia product to be implemented in learning) as
well as student review in the limited group trial of interactive multimedia developed is positive (the percentage gain of each aspect is in excellent interpretation), (2) interactive multimedia learning developed effectively to improving analytical
thinking ability of elementary school student.
Establishing Character Education in Elementary School: Increasing Concern and Environmental Responsibility Through Habiting and Modeling Working Group Activities
Authors: Amelia Dinie Rizky , Sumantri Mohamad Syarif , Utomo Erry
Published: February 2019

Character is an important and major in equipping the elementary school. Character education in elementary schools is not only applied in the classroom but can also be applied outside the classroom as well as in extracurricular activities of
working groups. In the extracurriculars the working group of students is divided into several activities. The working group (Pokja)consists of: (1) TOGA (Family Medicine Plants) pokja, (2) Planting pokja, (3) fishery pokja, (4) energy pokja, (5)
pokja biopori, and (6) a hygiene working group that will hold each program based on the group that has been determined. The research will be conducted on students of grade III in Elementary (Sekolah Dasar Negeri /SDN) Menteng 02, Central Jakarta with
the number of sample students. This study uses the design of classroom action research model Kemmis and Taggart consists of four stages of plan, action, observation, and reflection. After doing research, it is found that using modeling and
habituation in extracurricular activity process work group proved effective in increasing the character of responsibility and awareness to environment. This is because students are actively involved and there is a real example of the subject matter
that becomes the learning objective.
Convergence of the solutions of discounted Hamilton–Jacobi systems
Authors: Davini Andrea , Zavidovique Maxime
Published: February 2019

We consider a weakly coupled system of discounted Hamilton–Jacobi equations set on a closed Riemannian manifold. We prove that the corresponding solutions converge to a specific solution of the limit system as the discount factor goes to 0.
The analysis is based on a generalization of the theory
of Mather minimizing measures for Hamilton–Jacobi systems and on suitable random representation formulae for the discounted solutions.
On generalized fractional integration by parts formulas and their applications to boundary value problems
Authors: Kamocki Rafał
Published: February 2019

In the paper, we derive a formula of integration by parts for the left-sided Hilfer derivative. Moreover, we present a formula of such a type for the right-sided Hilfer derivative. These results generalize the well-known rules of integration by parts for the Riemann–Liouville and Caputo derivatives. Finally, we use these rules to investigate some boundary value problems involving mixed fractional derivatives.
Existence result for nonlinear fractional differential equations with nonlocal fractional integro-differential boundary conditions in Banach spaces
Authors: Seba Djamila , Rebai Hamza , Henderson Johnny
Published: February 2019

The nonlinear fractional differential equation with nonlocal fractional integro-differential boundary conditions in Banach spaces is studied, an existence result is obtained by using the method associated with the technique of measures of noncompactness and an appropriate fixed point theorem. An example is given to illustrate the theory.
A pilot study to improve sugar and water consumption in Maltese school children
Authors: Copperstone C. , McNeill G. , Aucott L. , Jackson D.M.
Published: February 2019

Background

Excessive sugar consumption remains implicated as one of the key dietary factors that has been linked to overweight and obesity in children. Schools have been identified as an important setting for health promotion interventions in children and can be successful in bringing about dietary behavioral change when well designed.

Objective

The main aim of the study was to conduct a pilot intervention study and assess the possible effects of educational and environmental methodological components on sugar intake and water consumption in Maltese school children.

Subjects and methods

Face-to-face educational sessions for children and parents were supported by written materials and provision of free drinking water for children for a 12 week period in the school setting. Two main dietary outcomes were measured: non-milk extrinsic sugars(NMES) intake (measured as g/day) and water consumption (measured as servings/day), measured in the pre- and post-intervention periods. The dietary outcomes were measured at school using the novel online dietary assessment tool, REALITYMALTA™.

Results

55 children, aged 10-11 years, were recruited, and 48 provided diet data at baseline and end. A reduction in mean energy intakes was noted from 7733 kJ/day (SD 2046) to 6809 (SD 2224) kJ/day (p = 0.03), with water servings intake increased and NMES intake decreased but results not statistically significant. Parent attendance at the educational sessions was low.

Conclusions

A larger scale study, including multi-level analysis is recommended. Modifying the content of the intervention and finding ways to increase parent engagement should be considered in future.
Bounds on real finite linear groups that preserve a symmetric or skew symmetric bilinear form
Authors: Collins Michael J.
Published: February 2019

We extend the results of our earlier work on Jordan-type bounds for finite subgroups of complex classical groups to real groups. The bounds that we obtain are related to our previous results by means of structural results for finite linear groups that we can generalise here to compact groups. For the real analogue of orthogonal groups, we take into account the signature of a real quadratic form to determine bounds in every case.
Extreme weather affects Peregrine Falcon (Falco peregrinus tundrius) breeding success in South Greenland
Authors: Carlzon Linnéa , Karlsson Amanda , Falk Knud , Liess Antonia , Møller Søren
Published: February 2019

In order to better understand the potential effects of climate change on the Peregrine Falcon, we investigated the relationship between extreme weather events and Peregrines’ breeding success in South Greenland. We defined three variables – number of days with extremely low temperatures, extreme precipitation, consecutive rainy days – and an additive variable, total days with extreme weather, and tested their relationship with Peregrines’ breeding success (measured as young per site and nest success) over a 33 year study period. Breeding success was negatively influenced by the number of days with extreme weather and extremely low temperature. The strongest relationship found was total days with extreme weather in the entire breeding season, which explained 22% and 27% of the variation in nest success and young per site, respectively. The number of days with extreme weather in our study related to fluctuations in the North Atlantic Oscillation (NAO). Thus, with a strengthening of the NAO, linked to climate change, more extreme weather may occur in the Arctic and induce increased variation in Peregrines’ breeding success. Our data did not allow us to pinpoint when in the breeding cycle inclement weather was particularly harmful, and we recommend finer-scale research (e.g. automated nest cameras) to better monitor the species-specific effects of rapidly changing climate.
The Danish Peregrine Falcon population: Reestablishment and eggshell thinning
Authors: Andreasen Niels Peter , Falk Knud , Møller Søren
Published: February 2019

Denmark being a country with only a few suitable steep nesting cliffs has only harboured a small population of Peregrine Falcons (Falco peregrinus) in historic time. In the previous century, the population gradually declined due to persecution, egg and young collection, and pollution. The last breeding attempt in the 20th century occurred in 1972 in southeastern Denmark. No new breeding attempts were recorded in Denmark until 2001 but since then the population has gradually increased – most rapidly since 2012 – to a peak of 24 territorial pairs in 2018; some of them breeding on man-made structures (nest boxes at bridges and power plants). Here we update the information on the reestablishment of the Peregrine Falcon in Den-mark, including origin and dispersal, reproduction, and eggshell thinning.
A 20-year study investigating the diet of Peregrines, Falco peregrinus, at an urban site in south-west England (1997–2017)
Authors: Dixon Nick , Drewitt Edward J. A.
Published: February 2019

Until relatively recently Peregrines have been regarded as a rural bird. As their populations have increased over the past 20 years, Peregrines have increasingly become urban birds. One of the earliest locations to be occupied by Peregrines in the UK was on a church in Exeter, in the county of Devon. Over the past 20 years we have studied their diet, collecting prey remains on a regular basis. The results reveal that Feral Pigeons Columba livia comprise one third of the diet by frequency and just over half of the diet when measured by mass. The remainder of the diet comprises a wealth of other species including wading birds, other doves and pigeons, ducks, gulls and terns, and rails. A selection of species eaten by the Peregrines reveal that they are hunting at night, taking certain wading birds, rails and grebes, that would be difficult to catch by day and are known to migrate at night. This study is the most comprehensive to date and reveals that while the Feral Pigeon is an important part of the diet, contrary to public opinion, it is by no means the only species that Peregrines eat. In fact, the remaining half of the diet, by mass, comprised 101 other species of bird and three species of mammal. Such dietary studies help dispel myths about peregrines feeding habits and ensure that their conservation and protection is based on evidence.
Diet of Peregrine Falcons (Falco peregrinus) in relation to temporal and spatial variation in racing pigeon availability in Wales
Authors: Dixon Andrew , Richards Colin , King Andrew
Published: February 2019

The relative frequency of Common Pigeons Columba livia in the diet of Peregrine Falcons differed across three areas of south-central Wales in line with racing pigeon availability. Peregrines exhibited a functional response to spatial and temporal availability of racing pigeons. During the pigeon-racing season (April–September), pigeons comprised 63% of kills in South Wales where pigeons were most available, 43% in the Brecon Beacons with intermediate availability and 30% in Central Wales, where availability was lowest. The corresponding values outside the pigeon-racing season were 18%, 6% and 5% respectively. We estimate that 92% of pigeons killed by Peregrines were racing pigeons, 7% were feral pigeons and the remainder were other domestic pigeon varieties.
In situneutron powder diffraction studies
Authors: Goonetilleke Damian , Sharma Neeraj
Published: February 2019

Neutron powder diffraction provides insight into the crystal and magnetic structures of materials. This insight can be achieved on pure materials under ambient conditions, but for greater understanding of the relationship between structure and function, crystallographic information during a process can prove powerful for rational material design strategies. These processes can involve temperature, applied magnetic or electric fields, applied pressure, gas dosing or devices such as electrochemical cells. These experiments are often referred to as a variable process orin situoroperandodepending on the conditions applied to the materials or devices. Sample environments to undertake such experiments are accessible at a range of neutron scattering facilities around world. This work provides details on the theory behind diffraction, a snapshot of neutron diffractometers that are suited to such experiments and recent studies exploring the power of neutron powder diffraction in elucidating crystal and magnetic structures under various external conditions.
Genome Analyses of a New Mycoplasma Species from the Scorpion Centruroides vittatus
Authors: Yamashita Tsunemi , Rhoads Douglas D , Pummill Jeff
Published: February 2019

Arthropod Mycoplasma are little known endosymbionts in insects, primarily known as plant disease vectors. Mycoplasma in other arthropods such as arachnids are unknown. We report the first complete Mycoplasma genome sequenced, identified, and annotated from a scorpion, Centruroides vittatus, and designate it as Mycoplasma vittatus. We find the genome is at least a 683,827 bp single circular chromosome with a GC content of 42.7% and with 987 protein-coding genes. The putative virulence determinants include 11 genes associated with the virulence operon associated with protein synthesis or DNA transcription and ten genes with antibiotic and toxic compound resistance. Comparative analysis revealed that the M. vittatus genome is smaller than other Mycoplasma genomes and exhibits a higher GC content. Phylogenetic analysis shows M. vittatus as part of the Hominis group of Mycoplasma. As arthropod genomes accumulate, further novel Mycoplasma genomes may be identified and characterized.
Relación entre la productividad, el mantenimiento y el reemplazo del equipamiento minero en la gran minería
Authors: Guerra-López Esmilka , Montes de Oca-Risco Alexis
Published: February 2019

La industria minera constituye uno de los renglones más importantes de la economía de la mayoría de los países, desarrollarla con la mayor eficiencia posible es tarea de primer orden para la ciencia, por lo que se emplean grandes esfuerzos en el estudio de las principales operaciones que la componen con el fin de optimizar recursos. El problema que fundamenta esta investigación es la necesidad de establecer la relación entre la productividad, el mantenimiento y el reemplazo del equipamiento minero que se utiliza en la minería a cielo abierto a gran escala, partiendo del análisis de su desempeño bajo condiciones concretas de explotación. Para tal fin se ha realizado la descripción del flujo tecnológico de la mina, caracterizando el equipamiento minero que interviene en el proceso de explotación, se han evaluado las condiciones bajo las que se realiza el reemplazo de la maquinaria y las afectaciones que las deficiencias en este proceso provocan al costo de operaciones. Se ha realizado una investigación de campo, aplicando como técnica principal el estudio de caso, cuyo resultado más relevante ha sido el cálculo del índice de productividad total del equipamiento de transporte, de excavación - carga y buldóceres al 6to año de explotación, cuyos valores han sido 51.72 %, 48.88 % y 55.51 % respectivamente, mostrando reducciones de productividad del parque me máquinas entre el 44% y el 51%. Dentro de las principales causas que han influido en la reducción del índice de productividad del parque de máquinas esta la disponibilidad técnica, acrecentada por las deficiencias en el cumplimiento de los planes de mantenimiento, que a su vez guarda estrecha relación con la modalidad de adquisición que se aplique en cada equipo en concreto y la decisión de reemplazar en el momento preciso.
Cold tolerance and changes in rates of synthesis of individual proteins of Clostridium perfringens as a result of cold pre-treatment
Authors: Villarreal L. , Heredia N. , Garcia S.
Published: February 2019

Clostridium perfringens is a widely distributed foodborne pathogen. Its ability to survive cold encounters could contribute to its persistence in foods and the potential to cause disease. In this work five cold-shock proteins (101, 82, 70, 45 and 10 kDa) were induced by cold-shocking C. perfringens FD-1041 from 43 °C to 28 °C, as revealed by labeling with L-[35S]methionine and cysteine followed by gel electrophoresis. Cold shock also increased the cold tolerance of the cells at least fifteen fold. The acquired tolerance was maintained for 2 h after the cold treatment. This ability of C. perfringens could improve the survival in foods and present a significant hazard.
Prolongation of shelf life of sponge cakes using modified atmosphere packaging
Authors: Rodriguez M. V. , Medina L. M. , Jordano R.
Published: February 2019

The effect of three different modified atmospheres on the shelf-life of sponge cake was studied. Three packaging atmospheres were tested: 50% CO2: 50% N2, 100% CO2, and standard air as control. The samples were examined daily for visible mould growth and analysed periodically (after 2, 6, 13, 22 and 27 days) throughout storage (15–20 °C and 51–63% RH) for gaseous composition and microbial populations: mesophilic aerobic and anaerobic bacteria, lactic acid bacteria (LAB) and yeasts and moulds. The atmosphere CO2:N2 (50:50) extended the shelf-life of the sponge cakes by 2–3 days with respect to packaging in standard air.
Sobre os 45 anos do Programa de Pós-Graduação em Educação da Unimep: uma vitoriosa experiência de consolidação da pesquisa
Authors: Severino Antonio Joaquim
Published: February 2019

Trata-se de um breve depoimento, ao ensejo de comemoração dos 45 anos do PPGE da Unimep, com o sentido de prestar-lhe  uma homenagem, reconhecendo sua contribuição à pesquisa educacional brasileira e registrando algumas referências históricas de sua trajetória, com destaque para a participação na sua implantação aos professores Richard Senn e Joel Martins, bem como acenando para os desafios que continuam se colocando para o projeto educacional da pós-graduação, no mudado contexto sócio-cultural e político da atualidade.Palavras-chave:
Avaliação da efetividade da esterilização química pelo ácido peracético em brocas odontológicas: estudo piloto
Authors: Oliveira Pablo Vargas de , Mandelli Jéssica Zolim Andreatto , Sonza Queli Nunes , Ehrhardt Alexandre
Published: February 2019

Devido ao risco de contaminação direta e cruzada dos instrumentais utilizados na prática odontológica por bactérias com potencial patogênico faz-se necessário o emprego de processos de esterilização. O ácido peracético apresenta indicação para tal, porém uma limitação do uso está relacionado ao  oxidação do instrumental. Considerando o exposto, o objetivo do trabalho foi verificar a eficácia do ácido peracético na descontaminação bacteriana das superfícies de brocas odontológicas, associado a ocorrência de corrosão destas. Através de um estudo experimental foi testada a eficácia do processo de esterilização do ácido em brocas de aço, carbide e diamantadas, contaminadas com biofilme bacteriano de cepas de S. aureus, S. mutans e E. faecalis. Também foi verificado através de microscopia eletrônica de varredura se houve oxidação na superfície das brocas. O ácido peracético mostrou-se efetivo na inibição do S. mutans nos três tipos de brocas, porém não inibiu crescimento de S. aureus, e E. faecalis nas brocas de aço.   Nas brocas carbide e diamantadas o ácido teve eficácia esperada, com inibição total do crescimento das 3 espécies testadas. Quanto aos níveis de oxidação da superfície, a broca que menos sofreu alteração foi a carbide. De acordo com os resultados obtidos, podemos considerar o ácido peracético como tendo uma efetividade subjetiva no processo de esterilização e um potencial de provocar alteração oxidativa do instrumental avaliado.
Avaliação do conhecimento e percepção da importância de saúde bucal pelos estudantes de odontologia
Authors: Leite Rafaella Bastos
Published: February 2019

Objetivo: avaliar o conhecimento de procedimentos de saúde bucal e a percepção da importância destes pelos estudantes dos vários períodos do curso de Odontologia da UEPB/Campina Grande, bem como observar o impacto e as mudanças sobre as condutas clínicas do futuro profissional diante dos pacientes por eles atendidos nas clínicas da referida universidade. Metodologia: Foi realizado um estudo transversal com 169 alunos, os quais responderam um formulário contendo perguntas relacionadas ao conhecimento, percepção da importância, práticas e mudanças de comportamento quanto à higiene bucal. A possível existência de diferenças significativas (p<0,05) ou correlações (r ou rpb≠0) entre as variáveis estudadas foram analisadas através dos testes estatísticos Qui-quadrado, correlações de Pearson e Point bisserial. Resultados: Todos os participantes admitiram como importante ou muito importante o conhecimento sobre Saúde/higiene bucal. A maioria (59,20%) considera satisfatória a abordagem sobre orientação e condutas clínicas relacionadas à motivação. A maioria dos participantes considerou muito importante a orientação do paciente (96,34%); apesar disso, 20,30% destes afirmaram não realizá-la durante a primeira consulta. Quanto à etiologia de certas patologias, a maior frequência de acertos está representada por alunos de períodos mais avançados, com médias entre 5,56 e 6,12. Observou-se que 77,5% relatou mudança nos hábitos de higiene bucal, contra 22,5% que disseram não ter tido mudança. Conclusão: Os instrumentos de higiene utilizados com maior frequência foram anti-séptico, dentifrício, escova macia e fio dental.
MAIC-COBIT: modelo interativo entre inteligência competitiva e governança de Tecnologia da Informação
Authors: Campos Fernando Celso , Prado Anderson Evandro
Published: February 2019

As organizações necessitam sempre estar atentas em relação ao ambiente competitivo, buscando atualizações e inovações para não serem surpreendidas pelos diversos fatos que podem influenciar seu negócio, direta ou indiretamente. A busca por técnicas que possam auxiliar as organizações são cada vez maiores e a Inteligência Competitiva (IC) é uma delas, obtendo e gerenciando informações úteis para fins econômicos e de negócios. Na literatura identificou-se 22 ciclos de inteligência competitiva possíveis e notou-se que não existe neles qualquer alinhamento a uma norma em geral e nem a uma norma de governança, com a finalidade de padronizar e avaliar o processo do ciclo de IC. O objetivo desse artigo é apresentar um método de avaliação do ambiente de IC, com base em uma norma de governança de TI, o CobiT v4.1. Esse método ficou denominado de MAIC_CobiT. A abordagem metodológica para gerar o MAIC-CobiT passou pela etapa de revisão bibliográfica identificando-se os ciclos de inteligência competitiva existentes, dos quais foi selecionado um deles que serviu de base para elaboração da proposta do método bem como alguns aspectos pré-selecionados da norma CobiT v4.1 e, posteriormente, foi feita uma etapa de verificação de sua aplicabilidade por meio de um questionário junto a 10 Profissionais e Acadêmicos previamente selecionados. Por meio do MAIC_CobiT, pretende-se garantir que o ambiente de IC passe a ser avaliado regularmente e ao longo do tempo torne-se mais estável além do que a organização possa obter maior vantagem competitiva em relação aos seus concorrentes, pela aplicação dos planos de ação prescritos.
Spatial dependence of attributes of rainfed maize under distinct soil cover conditions
Authors: Carvalho Ailton A. de , Montenegro Abelardo A. de A. , Assis Fred M. V. de , Tabosa José N. , Cavalcanti Roberta Q. , Almeida Thayná A. B.
Published: February 2019

ABSTRACT Maize crop under rainfed conditions is widely grown in the Brazilian Northeast on community farms for human and animal consumption. The application of mulch could be adopted to enhance rainwater harvesting and soil moisture levels, although such practice is rarely applied in rainfed cultivation. This study aimed to evaluate the spatial variability of maize productivity, based on soil physical attributes and plant growth and yield, under a rainfed regime in the presence and absence of mulch in the Brazilian semi-arid region. The study was conducted from May to September 2016 in Pesqueira - PE (locality of the Semiarid of Pernambuco State, Northeast, Brazil), during which the development and production of maize in experimental plots were evaluated, and maize was grown using the traditional cropping system with and without mulching. Two grids with 40 points in a 4 × 10 m mesh were established, with spacing of 1 m for soil sampling and maize biometric evaluation. For statistical analysis, 30 samples were randomly selected from each plot. Maize cultivated in the presence of mulch showed higher development, with symmetrical distribution for all variables except for soil moisture and stem diameter. Sand content, soil moisture, height of the first cob, number of leaves, leaf length, plant height, and cob weight presented moderate to strong spatial scale dependence for the two cropping conditions, with higher spatial dependence consistently observed for the development parameters in the covered area.
TEACHING OF THERAPEUTIC PLAY AT THE UNDERGRADUATE LEVEL IN NURSING: DIDACTIC ACTIONS AND STRATEGIES USED BY PROFESSORS
Authors: Maia Edmara Bazoni Soares , Ohara Conceição Vieira da Silva , Ribeiro Circéa Amália
Published: February 2019

ABSTRACT Objective: to present and discuss actions and strategies used by professors who teach therapeutic play in the Undergraduate Courses in Nursing. Method: qualitative research, that used symbolic interactionism as its theoretical framework, and Grounded Theory as its methodological framework. The scenario was the courses involving the theoretical-practical teaching of pediatric nursing, included in the curriculums of the Undergraduate Courses in Nursing. A total of 18 lecturers and three nurses participated, all involved in the process of teaching therapeutic play in the theoretical-practical scenario. Data were collected through participant observation and semistructured interviews. Results: it was revealed that the mobilization of the professors to teach therapeutic play in the Undergraduate Courses is permeated by a constant concern with offering and promoting significant learning to the student. They seek to do this through teaching strategies that involve: dramatization of therapeutic play sessions, the recovery of infancy and of playing, the use of audiovisual resources that raise awareness of learning, realistic simulation as innovation, the extending of possibilities of using Therapeutic Play, the re-presenting of therapeutic play to the student at the start of the practical activity, the providing of material for this practice, and the inclusion of the issue in the assessment process. Conclusion: the results contribute to assisting the lecturers in the task of awakening and introducing the student to the universe of therapeutic play, promoting her learning and systematic incorporation into academic life and, in the future, as a nurse, when she shall promote the inclusion of therapeutic play in the care provided to the child - in order to preserve and protect the child’s right to receive qualified care.
O custo social e econômico dos acidentes de trânsito com pedestres e ciclistas: estudo de caso do estado de Santa Catarina, Brasil
Authors: Tischer Vinicius
Published: February 2019

Resumo Os custos sociais decorrentes de acidentes de trânsito são elevados e impactam diretamente na economia. Entre as principais vítimas desses acidentes estão ciclistas e pedestres, os usuários mais vulneráveis. Nesse sentido, o objetivo foi desenvolver uma metodologia para estimar os custos gerados pelos acidentes de trânsito envolvendo pedestres e ciclistas. O estudo teve como referência dados disponíveis no Sistema de Informações de Saúde, vinculado ao Ministério da Saúde, considerando vítimas fatais e não fatais de acidentes. Para a composição dos custos de vítimas não fatais, foram utilizadas duas abordagens: uma considerando apenas despesas médico-hospitalares e outra levando em conta também os custos indiretos. Para acidentes fatais, empregou-se o método do capital humano, utilizando rendimentos fornecidos pelo IBGE como base para os cálculos. Como resultado, obtiveram-se diferentes aproximações de custos para cada tipo de ocorrência (lesões e vítimas fatais), demonstrando o ônus resultante do elevado número de acidentes. Os resultados obtidos podem ser utilizados em subsídio ao planejamento estratégico urbano e às políticas de segurança nos deslocamentos.