bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of polymorphisms, promoter methylation, and mRNA expression profile of maternal and placental P53 and P21 genes in preeclamptic and normotensive pregnant women
Authors: Harati-Sadegh Mahdiyeh , Kohan Leila , Teimoori Batool , Mehrabani Mehrnaz , Salimi Saeedeh
Published: November 2019

Background

Preeclampsia (PE), as a multisystem disorder, is associated with maternal hypertension and proteinuria. Apoptosis seems to be involved in the pathophysiology of PE, although its precise pathogenic mechanisms are not well established. In this study, we aimed to identify the association between maternal TP53-rs1042522, P21-rs1801270, and P21-rs1059234 polymorphisms and PE. In addition, we examined the effects of promoter methylation and TP53 and P21 polymorphisms on placental mRNA expression in PE women.

Methods

The blood of 226 PE women and 228 normotensive pregnant women was examined in this study. In addition, the placentas were genotyped in 109 PE and 112 control women. The methylation status was assessed by a methylation-specific PCR assay, while mRNA expression was examined via Quantitative Real Time PCR.

Results

The maternal and placental P21-rs1801270 CA genotype had a significant association with the reduced risk of PE. In the dominant, recessive, and allelic models, maternal/placental P21-rs1059234 polymorphism had no statistically significant association with the risk of PE. On the other hand, the reduced risk of PE was associated with maternal, but not placental TP53-rs1042522 polymorphism in the dominant and recessive models. The maternal and placental P21-rs1801270 polymorphism was associated with PE risk. The maternal P21 Trs1059234Crs1801270 haplotype was associated with 3.4-fold increase in PE risk, However the maternal P21 Trs1059234Ars 1801270 haplotype and placental Crs1059234CA rs1801270 haplotype led to 0.5 and 0.4-fold decrease in PE risk, respectively. PE women showed 5.6 times higher levels of placental mRNA expression of TP53 gene, although it was not associated with rs1042522 polymorphism. The relative placental mRNA expression of P21 gene was 0.2 in PE women. It was also 2.4 times higher in individuals with rs1801270CA genotype than those with AA genotype. The hyper-methylation of P21 and TP53 genes in the promoter region was associated with a 3.4-fold and 3-fold increase in PE risk, respectively. However, no association was found between P21 and TP53 mRNA expression and promoter methylation.

Conclusion

In conclusion, P21-rs1801270 and TP53-rs1042522 polymorphisms were involved in reduced risk of PE. P21-rs1801270 was associated with decreased P21 mRNA expression. The hyper-methylation of P21 and TP53 genes in the promoter region was associated with a higher PE risk.
Acupuncture and herbal moxibustion for the treatment of ‘BiQiu’ (allergic rhinitis symptoms) in a Hong Kong Chinese medicine clinic: a randomized controlled trial
Authors: Yung Ting Yiu , Zhang Hongwei , Tang Lap Che , Zhang Lang , Law Chak On , Tam Wai Man , Chan Chun Wai , Chen Heng Chun , Lee Man Hork , Ziea Tat Chi , Ng Fung Leung , Lin Zhi Xiu
Published: November 2019

Background

Allergic rhinitis (AR) is a common disease. No evidence is available for the clinical application of acupuncture and moxibustion for the management of AR symptoms in Hong Kong. This study aimed to evaluate the clinical effectiveness of acupuncture with or without herbal moxibustion on relieving AR symptoms in the Hong Kong population.

Methods

A single-centre, randomized, assessor-blinded, controlled trial with three parallel arms (acupuncture alone, acupuncture combined with herbal moxibustion treatment and waitlist) was designed. Groups with acupuncture treatment received treatment 3 times per week for a total of 12 sessions in 4 weeks. Acupuncture combined with herbal moxibustion treatment group received herbal moxibustion once per week for a total of 4 sessions over 4 weeks in addition to acupuncture treatment. Participants in the waitlist group received no treatment. All patients received advice on healthy lifestyle, diet, and exercise.

Results

Ninety-six subjects were recruited and allocated randomly (1:1:1) into three study groups. Compared to the waitlist group, both treatment groups demonstrated statistically significant decreases in TNSS and RQLQ at the end of treatment as well as after follow-up period (all P < 0.01). However, there was no statistically differences between these two treatment groups. There was no difference in the change of total IgE levels among study groups before or after the treatment. Only one patient reported adverse effects with herbal moxibustion treatment, and no adverse effects were found in others.

Conclusions

This study supports that acupuncture could help relieve AR symptoms, but no evidence on additional treatment effect of herbal moxibustion was found.

Trial registration ChiCTR-INR-16010047 registered on November 25, 2016.
Risk factors and predicted distribution of visceral leishmaniasis in the Xinjiang Uygur Autonomous Region, China, 2005–2015
Authors: Ding Fangyu , Wang Qian , Fu Jingying , Chen Shuai , Hao Mengmeng , Ma Tian , Zheng Canjun , Jiang Dong
Published: November 2019

Background

Visceral leishmaniasis (VL) is a neglected disease that is spread to humans by the bites of infected female phlebotomine sand flies. Although this vector-borne disease has been eliminated in most parts of China, it still poses a significant public health burden in the Xinjiang Uygur Autonomous Region. Understanding of the spatial epidemiology of the disease remains vague in the local community. In the present study, we investigated the spatiotemporal distribution of VL in the region in order to assess the potential threat of the disease.

Methods

Based on comprehensive infection records, the spatiotemporal patterns of new cases of VL in the region between 2005 and 2015 were analysed. By combining maps of environmental and socioeconomic correlates, the boosted regression tree (BRT) model was adopted to identify the environmental niche of VL.

Results

The fitted BRT models were used to map potential infection risk zones of VL in the Xinjiang Uygur Autonomous Region, revealing that the predicted high infection risk zones were mainly concentrated in central and northern Kashgar Prefecture, south of Atushi City bordering Kashgar Prefecture and regions of the northern Bayingolin Mongol Autonomous Prefecture. The final result revealed that approximately 16.64 million people inhabited the predicted potential infection risk areas in the region.

Conclusions

Our results provide a better understanding of the potential endemic foci of VL in the Xinjiang Uygur Autonomous Region with a 1 km spatial resolution, thereby enhancing our capacity to target the potential risk areas, to develop disease control strategies and to allocate medical supplies.
Statins and/or fibrates for diabetic retinopathy: a systematic review and meta-analysis
Authors: Mozetic Vânia , Pacheco Rafael Leite , Latorraca Carolina de Oliveira Cruz , Riera Rachel
Published: November 2019

Evidence from observational studies have found a relationship between serum cholesterol and diabetic retinopathy (DR). Apart of the assumption that cholesterolemic control has benefits for patients with diabetes with or without retinopathy, the effects of lipid-lowering drugs have not been properly mapped and critically assessed so far. The objective of this study was to evaluate the effects of statins and/or fibrates on prevention and progression of DR. We conducted a Systematic review of randomized controlled trials (RCTs) following the Cochrane Handbook for Systematic Reviews of Interventions and reported in accordance to PRISMA Statement. GRADE approach was used to summarize the certainty of the evidence. Eight RCTs that fulfilled our eligibility criteria were included, assessing the effects of fibrates (n = 4), statins (n = 3) and fibrate plus statins (n = 1) for therapy (n = 8) or prevention (n = 4) of DR. Overall, the main concern regarding risk of bias assessment was due to incomplete outcome data because high rate of losses in five RCTs. Furthermore, the risk of reporting bias was rated unclear due the lack of previously published protocol in seven RCTs. Fibrates seemed to be associated with a 45% risk reduction of macular edema incidence (Relative Risk 0.55, 95% confidence interval of 0.38 to 0.81, 1309 participants, 2 RCTs, I2 = 0%, low certainty of the evidence). The certainty of evidence for other outcomes was also very low or low, and we are uncertain regarding the effects of fibrates for DR. Overall, adverse events seemed to be similar between fibrate and placebo, but again based on the width of the confidence intervals, an important increase of adverse events cannot be rule out. The combination statin/fibrate did not seem to have benefit for visual acuity but is likely that further studies can modify this estimate since the current evidence is limited. Adverse events and quality of life were not measured or reported. Concluding, this study found eight RCTs, with limited methodological quality, that assessed the effects of fibrates and/or statins for DR. Based on these findings, we are uncertain about the effects of statins for DR. Fibrates seemed to reduce the incidence of macular edema (low certainty evidence) without increase adverse events (low to very low certainty evidence).

Number of Protocol registration PROSPERO CRD42016029746.
A theory-guided deep-learning formulation and optimization of seismic waveform inversion
Authors: Sun Jian , Niu Zhan , Innanen Kristopher A. , Li Junxiao , Trad Daniel O.
Published: November 2019

Deep-learning techniques appear to be poised to play very important roles in our processing flows for inversion and interpretation of seismic data. The most successful seismic applications of these complex pattern-identifying networks will, presumably, be those that also leverage the deterministic physical models on which we normally base our seismic interpretations. If this is true, algorithms belonging to theory-guided data science, whose aim is roughly this, will have particular applicability in our field. We have developed a theory-designed recurrent neural network (RNN) that allows single- and multidimensional scalar acoustic seismic forward-modeling problems to be set up in terms of its forward propagation. We find that training such a network and updating its weights using measured seismic data then amounts to a solution of the seismic inverse problem and is equivalent to gradient-based seismic full-waveform inversion (FWI). By refining these RNNs in terms of optimization method and learning rate, comparisons are made between standard deep-learning optimization and nonlinear conjugate gradient and limited-memory Broyden-Fletcher-Goldfarb-Shanno (L-BFGS) optimized algorithms. Our numerical analysis indicates that adaptive moment (or Adam) optimization with a learning rate set to match the magnitudes of standard FWI updates appears to produce the most stable and well-behaved waveform inversion results, which is reconfirmed by a multidimensional 2D Marmousi experiment. Future waveform RNNs, with additional degrees of freedom, may allow optimal wave propagation rules to be solved for at the same time as medium properties, reducing modeling errors.
Structures of MERS1, the 5′ processing enzyme of mitochondrial mRNAs in Trypanosoma brucei
Authors: Schumacher Maria A. , Henderson Max , Zeng Wenjie
Published: November 2019

Most mitochondrial mRNAs are transcribed as polycistronic precursors that are cleaved by endonucleases to produce mature mRNA transcripts. However, recent studies have shown that mitochondrial transcripts in the kinetoplastid protozoan, Trypanosoma brucei, are transcribed individually. Also unlike most mitochondrial mRNAs, the 5′ end of these transcripts harbor a triphosphate that is hydrolyzed. This modification is carried out by a putative Nudix hydrolase called MERS1. The Nudix motif in MERS1 is degenerate, lacking a conserved glutamic acid, thus it is unclear how it may bind its substrates and whether it contains a Nudix fold. To obtain insight into this unusual hydrolase, we determined structures of apo, GTP-bound and RNA-bound T. brucei MERS1 to 2.30 Å, 2.45 Å, and 2.60 Å, respectively. The MERS1 structure has a unique fold that indeed contains a Nudix motif. The nucleotide bound structures combined with binding studies reveal that MERS1 shows preference for RNA sequences with a central guanine repeat which it binds in a single-stranded conformation. The apo MERS1 structure indicates that a significant portion of its nucleotide binding site folds upon substrate binding. Finally, a potential interaction region for a binding partner, MERS2, that activates MERS1 was identified. The MERS2-like peptide inserts a glutamate near the missing Nudix acidic residue in the RNA binding pocket, suggesting how the enzyme may be activated. Thus, the combined studies reveal insight into the structure and enzyme properties of MERS1 and its substrate-binding activities.
Estrutura de controle e performance financeira: Uma análise de empresas brasileiras listadas e deslistadas, negociadas no Brasil e nos Estados Unidos
Authors: Granzotto Alberto , Bernardi Sonza Igor
Published: November 2019

O presente trabalho buscou identificar a influência da estrutura de controle do acionista  majoritário no desempenho contábil e de mercado das empresas brasileiras listadas e deslistadas negociadas somente na B3 em comparação com as que possuem dupla listagem com os EUA (ADRs). Para este fim, foram aplicadas regressões lineares com dados em painel não balanceados por GMM-Sys. Ficou evidenciado que a estrutura de controle do acionista principal é negativamente relacionada com o desempenho financeiro para as empresas listadas somente na B3, e positivamente relacionada com esse desempenho para as empresas deslistadas, prevalecendo o conflito entre acionistas. Esse contexto é inverso ao encontrado na análise das ADRs, onde a estrutura de controle é positivamente relacionada com o desempenho financeiro enquanto listadas e negativamente relacionada quando ocorre a deslistagem, comprovando que, neste caso, os conflitos de agência prevalecem. Esse estudo confirma que os efeitos da Common Law norte-americana também afetam as empresas brasileiras que são negociadas nos EUA.
Are higher-order factors useful in pricing the cross-section of hedge fund returns?
Authors: Almeida Caio , Fang Elaine
Published: November 2019

This paper investigates hedge funds’ exposures to various risk factors across different investment strategies through models with both linear and second-order factors. We extend the analysis from an augmented linear model based on Fama & French (1993) and Fung & Hsieh (2001) to second-order models that include all quadratic and interaction terms by adopting a novel multistep strategy that combines the variable selection capabilities of the LASSO regression with the Fama & MacBeth (1973) two-step method. We find that, for some strategies, several quadratic and interaction terms are statistically significant. Nonetheless, there is no evidence that the second-order models have more overall explanatory or predictive power than the linear model. Moreover, while both linear and second-order models perform well for directional funds (like emerging markets, event driven and managed futures), missing factors may still remain for semi-directional funds, such as fund of funds, long/short equity hedge and multi-strategy.
Governança corporativa e sensibilidade investimento-fluxo de caixa no Brasil
Authors: Silva Breno Augusto de Oliveira , Caixe Daniel Ferreira , Krauter Elizabeth
Published: November 2019

O objetivo deste estudo foi investigar a sensibilidade do investimento ao fluxo de caixa para empresas brasileiras com diferentes níveis de governança corporativa. Modelos de investimento foram estimados pelo Método dos Momentos Generalizados Sistêmico (GMM-Sys) em dados longitudinais de 248 companhias brasileiras de 2006 a 2015. Estas foram classificadas a priori em dois grupos de qualidade de governança de acordo com o Índice de Práticas de GovernançaCorporativa (IPGC). Os resultados demonstraram que a qualidade da governança corporativa influenciou a sensibilidade investimento-fluxo de caixa, sendo essa relação negativa e significante apenas para as empresas com pior governança. Esse resultado pode ser interpretado como um indício de que tais firmas buscam aumentar suas reservas de caixa e reduzir investimentos por motivos relacionados a restrições financeiras e/ou a problemas de agência.
Performance dos bancos brasileiros no contexto de digitalização
Authors: Freitas Otavio Dias , Kirch Guilherme
Published: November 2019

Considerando o contexto de digitalização do sistema bancário brasileiro, o presente estudo avalia como o investimento em tecnologia vem afetando a performance das instituições financeiras. Diversos estudos avaliaram o impacto da digitalização nos resultados dos bancos. Hernando & Nieto (2007) e Ciciretti, Hasan & Zazzara (2009) identificaram ganhos de rentabilidade e redução de custos com a implantação do internet banking nos bancos espanhóis e italianos. Neste estudo foram analisadas, por meio de regressões lineares, a relação entre investimentos em TI e medidas de rentabilidade (ROA, ROE e margem de intermediação) e despesas (de pessoal e administrativas). Foi também avaliada, por meio de uma análise envoltória de dados (DEA), a evolução das eficiências técnica, de custos e alocativa dos bancos brasileiros, sendo os resultados segregados em termos dos investimentos em TI. Os resultados sugerem que o investimento em tecnologia da informação pelos bancos possui uma relação significativamente positiva com as variáveis de rentabilidade e negativa com as despesas administrativas, corroborando parcialmente com os estudos de Hernando & Nieto (2007). Foi verificado também melhora na eficiência técnica dos bancos brasileiros ao longo do período analisado, principalmente entre aqueles que possuem maior investimento em TI.
Antiarrhythmic drugs. Part 3: rate-control drugs
Authors: Sampson Michael
Published: November 2019

Rate-control drugs are used to reduce the ventricular rate during atrial arrhythmias and are widely used in both primary and secondary care. In this final instalment of a three-part article series, we evaluate three commonly used rate-control agents: bisoprolol, diltiazem, and digoxin. Of these, bisoprolol has the widest range of indications as it is also used in the prevention of ventricular arrhythmias. It has the best safety profile of the three drugs owing to its combined renal and hepatic excretion. Diltiazem and digoxin have a narrower range of use and carry a greater risk of toxicity as a result of their reliance on either hepatic or renal elimination. These issues are explored alongside consideration of evidence base for use, dosing, and interactions. The focus is on information that supports safe prescribing and administration.
Rainbow Trust neonatal care
Authors: Harris Anne
Published: November 2019

With an increased number of families now caring for a seriously ill baby, Rainbow Trust Children's Charity is responding by providing vital emotional and practical support for these families
Breast milk donation and bereavement
Authors: Winter George F.
Published: November 2019

The decision about whether to donate breast milk after the death of an infant can be a challenging one for a mother to make. George F Winter explores this as a method for healing
Drug Breakdown: Methotrexate
Authors: Rees Sharon
Published: November 2019

In this column, Sharon Rees aims to refresh knowledge and interest in some of the commonly used drugs in a series of tweets. This month she is talking about #methotrexate
Research Roundup
Authors: Paterson Ruth
Published: November 2019

Ruth Paterson provides an overview of recently published articles that may be of interest to non-medical prescribers. Should you wish to look at any of the papers in more detail, a full reference is provided
Deprescribing in end-of-life care
Authors: Gardner Emma
Published: November 2019

The aim of deprescribing in end-of-life care is to improve the patient's quality of life by reducing their drug burden. It is essential to engage the patients and enable them to make choices about medications by discussing their preferences and implement a pharmacy management plan. Withdrawing medications during the end stages of life is extremely complex because the period of care varies substantially. The aim of this article is to address polypharmacy within end-of-life care. It will review which medications should be stopped by examining the non-essential and essential drugs. The intention is to encourage an approach to care which provides an equal balance between treatment and patient expectation.
Mediated ambition? Gender, news and the desire to seek elected office
Authors: Pruysers Scott , Thomas Melanee , Blais Julie
Published: November 2019

A gender gap in nascent political ambition is among the best documented in political behaviour. Although the reasons for this gender gap are numerous, it has often been speculated that the media might be partly responsible for suppressing ambition among women. Considerable evidence shows that women in politics are generally subject to more attention being paid to their appearance, marital status and sex than their male counterparts. Does this kind of media coverage dampen political ambition? We test this possibility in two experimental studies. In Study 1, we explore whether overtly sexualised coverage regarding the appearance of politicians can dampen political ambition, while Study 2 considers whether media coverage focusing on the private lives of politicians (specifically parental/marital status) affects political ambition. This two-study approach allows us to consider whether media coverage of political officials is related to political ambition and whether different types of media coverage have different effects.
Destabilization, adaptation and the long-term fan object: The search for continuity in later-life sports fandom
Authors: Smith Joseph Andrew
Published: November 2019

Whilst there is a growing literature in fan studies on the ageing fan, there is a distinct lack of engagement with the body of work already established within the ‘ageing sciences’, such as gerontology. This article begins to address such issues by applying the gerontological notion of continuity theory to the study of later-life, long-term sports fandom. Drawing on in-depth, semi-structured interviews with 35 retired or semi-retired sports fans, all of whom are in the third and fourth ‘life ages’, this article argues for a theory of fan continuity whereby the fan adapts their relationship to the fan object in response to various challenges to their fandom. These challenges to the fannish status quo are destabilizations, which, upon an adaptation on behalf of the fan and ultimate re-stabilization of the fandom, result in an outcome which can be assessed on a positive–negative experiential continuum. This is a continuous process as the later-life adult looks for consistency of self, and continuity in fandom.
Editorial
Authors: Groener Zelda , Walters Shirley
Published: November 2019

This special issue of the Journal of Vocational, Adult and Continuing Education and Training (JOVACET) presents a collection of research papers on adult learners’ access to learning opportunities in post-school education and training (PSET). It was prompted by a conference entitled, Access, barriers to participation and success for adult learners: Rethinking equity and social justice in post-school education, held in Cape Town on 24–25 November 2018, where early versions of the articles featured were presented.
Histoire de l’édition en Belgique. XVe-XXIe siècle (P. Durand, T. Habrand, 2018)
Authors: Dutron Martin
Published: November 2019

Recensé : Pascal Durand et Tanguy Habrand, Histoire de l’édition en Belgique. XVe-XXIe siècle, Paris/Bruxelles, Les Impressions Nouvelles, 2018 (« Réflexions faites »), 576 p.
Aux sons des mémoires. Musiques, archives et terrains (A. Aterianus-Owanga et J. P. Santiago, dir., 2016)
Authors: Rivera Andía Juan Javier
Published: November 2019

Recensé : Alice Aterianus-Owanga et Jorge P. Santiago (dir.), Aux sons des mémoires. Musiques, archives et terrains, Lyon, Presses universitaires de Lyon, 2016 (« Nouvelles Écritures de l’anthropologie »), 206 p.
PENGAMBILAN KEPUTUSAN UNTUK KUALITAS AIR PADA TAMBAK UDANG MENGGUNAKAN FUZZY LOGIC CONTROL
Authors: Dwisaputra Indra , Rolastin Boy , Irwan Irwan , Sateria Angga
Published: November 2019

Indra Dwisaputra, Boy Rolastin, Irwan, Angga Satera, in this paper explain that one commodity that can be used as a superior post-mining area such as Bangka Belitung is shrimp ponds. Touch of technology is needed because of high rainfall in this area so that changes in temperature, humidity, salinity and pH are more dynamic. Then we need a control to determine the water quality in shrimp ponds to avoid crop failure. This research was conducted by means of simulations to make it easier to analyze the results before applying. Fuzzy logic control (FLC) method is used for the water quality decision making system. By utilizing 3 input variables such as temperature, salinity and pH of water and output is an index of water quality from a scale of 0-100. The Mamdani method is applied to FLC with 27 fuzzy rules. The simulation results show that a change in one of the input variables can cause water quality to drop to 70. When there are changes in the two input variables, it can reduce water quality by 25.1. FLC can work well in decision making for water quality in shrimp culture.
Cities & International Policy Diffusion: The Case of Tokyo
Authors: Chiu Nikita
Published: November 2019

In an increasingly globalised world, today’s international challenges such as climate change transcend national boundaries and require multi-level governance responses. Cities, in particular, stand out as an essential governing unit with huge potentials in resolving some of the 21st century’s most pressing concerns. The recent explosion of the phenomenon of city-networks reflects intensifying city-to-city interactions in addressing global environmental issues. This article examines the case of Tokyo in addressing challenges posed by climate change. Examining the origin, development, and diffusion of Tokyo’s climate change policy, the cap-and-trade scheme was found to have first diffused from Europe to Tokyo, adjusted to adapt to the local context, then further diffused to other Asian cities. Study of Tokyo’s experience demonstrates that policy formation does not always follow a centralized, top-down, command-and-control approach. This findings challenge conventional realist conception which emphasises the dominance of central authorities and sovereign states in global policy formation. Under the framework of global governance, this article argues that cities are important sites of policy experimentation and innovation, and that the case of Tokyo demonstrates the potential of cross-country policy diffusion.
Clinical application of a dried blood spot assay for sirolimus and everolimus in transplant patients
Authors: Veenhof Herman , Koster Remco A. , Alffenaar Jan-Willem C. , van den Berg Aad P. , de Groot Marco R. , Verschuuren Erik A.M. , Berger Stefan P. , Bakker Stephan J.L. , Touw Daan J.
Published: November 2019

Background

Monitoring of immunosuppressive drugs such as everolimus and sirolimus is important in allograft rejection prevention in transplant patients. Dried blood spots (DBS) sampling gives patients the opportunity to sample a drop of blood from a fingerprick at home, which can be sent to the laboratory by mail.

Methods

A total of 39 sirolimus and 44 everolimus paired fingerprick DBS and whole blood (WB) samples were obtained from 60 adult transplant patients for method comparison using Passing-Bablok regression. Bias was assessed using Bland-Altman. Two validation limits were pre-defined: limits of analytical acceptance were set at >67% of all paired samples within 20% of the mean of both samples and limits of clinical relevance were set in a multidisciplinary team at >80% of all paired samples within 15% of the mean of both samples.

Results

For both sirolimus and everolimus, Passing-Bablok regression showed no differences between WB and DBS with slopes of 0.86 (95% CI slope, 0.72–1.02) and 0.96 (95% CI 0.84–1.06), respectively. Only everolimus showed a significant constant bias of 4%. For both sirolimus and everolimus, limits of analytical acceptance were met (76.9% and 81.8%, respectively), but limits or clinical relevance were not met (77.3% and 61.5%, respectively).

Conclusions

Because pre-defined limits of clinical relevance were not met, this DBS sampling method for sirolimus and everolimus cannot replace WB sampling in our center at this time. However, if the clinical setting is compatible with less strict limits for clinical relevance, this DBS method is suitable for clinical application.
Linearity of some low-complexity mapping class groups
Authors: Soroko Ignat
Published: November 2019

By analyzing known presentations of the pure mapping groups of orientable surfaces of genus g with b boundary components and n punctures in the cases when

g
=
0

{g=0}

with b and n arbitrary, and when

g
=
1

{g=1}

and

b
+
n

{b+n}

is at most 3, we show that these groups are isomorphic to some groups related to the braid groups and the Artin group of type

D
4

{D_{4}}

.
As a corollary, we conclude that the pure mapping class groups are linear in these cases.
Solution method for ill-conditioned problems based on a new improved fruit fly optimization algorithm
Authors: Fan Qian , Meng Xiaolin , Xu Chengquan , Yu Jiayong
Published: November 2019

Based on deeply analysis for optimization process of basic fruit fly optimization algorithm (FOA), a new improved FOA (IFOA) method is proposed, which modifies random search direction, increases the adjustment coefficient of search radius, and establishes a multi-sub-population solution mechanism. The proposed method can process the nonlinear objective function that has non-zero and non-negative extreme points. In the paper, IFOA method is applied to ill-conditioned problem solution in the field of surveying data processing. Application of the proposed method on two practical examples show that solution accuracy of IFOA is superior to that of three well-known intelligent optimization algorithms and two existing improved FOA methods, and it is also better than truncated singular value decomposition method and ridge estimation method. In addition, compared with intelligent search method represented by particle swarm optimization algorithm, The IFOA method has the advantages of less parameter settings, simple optimization process and easy program implementation. So, IFOA method is feasible, effective and practical in solving ill-conditioned problems.
A kind of dual form for coupling from the past algorithm, to sample from Markov chain steady-state probability
Authors: Nasroallah Abdelaziz , Bounnite Mohamed Yasser
Published: November 2019

The standard coupling from the past (CFTP) algorithm is an interesting tool to sample from exact Markov chain steady-state probability.
The CFTP detects, with probability one, the end of the transient phase (called burn-in period) of the chain and consequently the beginning of its stationary phase.
For large and/or stiff Markov chains, the burn-in period is expensive in time consumption.
In this work, we propose a kind of dual form for CFTP called D-CFTP that, in many situations, reduces the Monte Carlo simulation time and does not need to store the history of the used random numbers from one iteration to another.
A performance comparison of CFTP and D-CFTP will be discussed, and some numerical Monte Carlo simulations are carried out to show the smooth running of the proposed D-CFTP.
The Rosko Hoard – a Road Sign? Research and its Perspectives: Mass Deposition of Metal Objects, Late Bronze and Early Iron Ages in Poland
Authors: Maciejewski Marcin
Published: November 2019

The phenomenon of depositing various types of goods was practiced in Europe across the annals of all time. Known from the Bronze Age and in some regions of the continent, also from the Early Iron Age, metal object hoards are one of the most spectacular and easiest for identification as well as the most often recorded and analyzed illustration of this phenomenon. In being a specific category of archaeological finds in many respects – as far as the meaning of these practices in the culture of prehistoric communities, as well as the circumstances of their discovery – they were for many decades investigated in a particular way. In this context, unusually high emphasis was placed on typological analysis and the dominant forms of research were regional monographs.

The resulting impasse of using limited data for the purposes of argumentation in favour of one of the hypotheses (sacral or profane) was underscored in the literature many a time. Both the development of archaeology and the significant growth of the number of newly discovered metal artefact assemblages, leads one to considerations over the appropriate means for conducting research on these enigmatic finds. The past few years have brought a series of new research propositions in respect to the means of investigating and interpreting this very phenomenon. The hoard from Rosko one could argue is not only worth exemplification on account of the significant research information it brings, but also as a means of indicating how research on hoards may be conducted.
Bjørn Rabjerg, Robert Stern: On Knud E. Løgstrup’s “Humanism and Christianity”
Authors: Rabjerg Bjørn , Stern Robert
Published: November 2019

Dieser Beitrag bietet eine umfassende Diskussion des Textes “Humanismus und Christentum” (1950) des dänischen Philosophen und Theologen Knud E. Løgstrup. Er verortet den Text in seinem geistesgeschichtlichen Kontext und analysiert seine wichtigsten Argumente wie auch seine zentrale These, der zufolge Humanismus und Christentum einen entscheidenden Grundsatz teilen, insofern beide die Ethik als “stumm“ oder “unausgesprochen“ verstehen. Darüber hinaus wird dargelegt, wie Løgstrups Text zentrale Überlegungen in dessen späteren Publikationen, besonders in dem Hauptwerk Die ethische Forderung (1956), vorwegnimmt.
REPRESENTACIONES DE LA LENGUA PORTUGUESA EN LA ARGENTINA: LA BIBLIOTECA DE AUTORES BRASILEÑOS TRADUCIDOS AL CASTELLANO
Authors: Pasero Carlos Alberto
Published: November 2019

Este estudio analiza las representaciones sobre el portugués en los principales textos y paratextos que conforman la Biblioteca de Autores Brasileños Traducidos al Castellano, publicada por el gobierno argentino entre 1939 y 1943. La supremacía de una "diplomacia del intelecto" en la Biblioteca de Autores Brasileños Traducidos al Castellano, tiñe el discurso referido al Brasil, al portugués y sus culturas y es el resultado de una perspectiva liberal y "mitrista" de apertura integradora con respecto al Brasil. Es la impronta de la Academia Nacional de la Historia presidida por Ricardo Levene. Se podría decir que un sector del campo intelectual se conforma con el objetivo de estudiar y divulgar la cultura brasileña en el marco de una política de mejoramiento de las relaciones bilaterales, de un mayor conocimiento del país vecino e del incremento del intercambio de bienes culturales.Palavras-chave: Representações linguísticas; estatuto formal e informal de língua; mediação cultural; campo intelectual
PRIMO LEVI: A QUÍMICA ENTRE LITERATURA E CIÊNCIA
Authors: Maciera Aislan Camargo
Published: November 2019

Primo Levi (1919-1987), italiano de origem judaica, antifascista e químico de formação, passa quase um ano de sua vida como prisioneiro em um dos campos de concentração de Auschwitz. Preso como partigiano, deportado como judeu, e sobrevivente por acaso, Levi faz daquela experiência, o ponto de partida de sua literatura. Sua grande vocação narrativa faz com que cultive os mais diversos gêneros ao longo de sua carreira. A análise da obra literária de Levi, obrigatoriamente, deve considerar dois aspectos, que estão na gênese e na construção de seus escritos: o primeiro é a origem de sua literatura, nascida da experiência como prisioneiro e da observação daquele universo; o segundo é a sua formação, pois, como químico, o olhar que dirigia ao mundo era determinado pelos preceitos da ciência que escolheu. O artigo pretende expor uma análise da literatura de Levi a partir da relação que ela estabelece com a ciência, com a técnica e, mais especificamente, com a química. As referências para a análise são suas entrevistas e ensaios a respeito do tema, bem como o livro que mais claramente representa a relação entre ciência e literatura em sua obra: A tabela periódica. Dessa forma, conclui-se que nenhuma página escrita pelo autor está dissociada de sua formação científica, e isso influencia diretamente o seu estilo, transformando-o em um dos principais representantes, na literatura universal, da relação entre “as duas culturas”, como também em um dos principais prosadores da segunda metade do século XX.Palavras-chave: Literatura italiana; Primo Levi; literatura e ciência; literatura e química.
LA ESTRATEGIA DEL MERODEO: UN RECORRIDO POR EL VÉRTIGO HORIZONTAL DE JUAN VILLORO
Authors: Croce Marcela
Published: November 2019

El artículo propone que El vértigo horizontal (2018) de Juan Villoro es un libro que oscila entre el ensayo y la crónica y sugiere que el ensayo es la forma reflexiva de la crónica. En la mirada que participa por igual de la mordacidad y el afecto, Villoro diseña una ciudad de México recorrida bajo las virtualidades del transporte público, con líneas independientes pero que se cruzan y trazan correspondencias desde las cuales se garantiza un itinerario completo. Esa urbe que participa de la hospitalidad y el escándalo reclama situar al autor en una serie mexicana y latinoamericana. La propiamente mexicana ubica a Villoro dentro de la tradición de la crónica en que coincide contemporáneamente con Carlos Monsiváis, aunque atraviesa al menos dos siglos de ejercicio constante; la latinoamericana aproxima al escritor a las “espléndidas amarguras” que Borges le atribuyó a Ezequiel Martínez Estrada cuando abordó la pampa –y luego la ciudad de Buenos Aires—con una desolación empecinada. La experiencia de la ciudad se plasma en un conjunto de viñetas de crónica ensayística que insisten en la relevancia del antiguo DF para una definición no ya de la literatura sino de la identidad mexicana, cuya inscripción latinoamericana habilita las genealogías intelectuales que aquí se postulan.Palabras clave: Crónica; Ensayo; Ciudad latinoamericana; Serie intelectual.
A EXPERIÊNCIA POÉTICA DE DANILO GIROLDO
Authors: Bolaños Aimée
Published: November 2019

O presente artigo constitui uma leitura de viés hermenêutico do livro de poemas Vala (2019), de Danilo Giroldo. A análise está centrada tanto nos aspectos cosmovisivos como compositivos, com particular interesse nas categorias de metapoesia, metapoeta, enunciação metafórica e aberturas simbólicas. Inclui-se, ademais, um diálogo com o autor que aborda sua experiência criativa, motivações, destinários, dimensões sociais, de modo que também se faz presente a voz e visão do poeta. As conclusões contribuem ao conhecimento da literatura atual brasileira desde a perspectiva crítica de uma obra, evidenciando elementos distintivos de sua poética em uma complexa representação da temporalidade histórica e do tempo humano na poesia.Palavras chave: Poesia brasileira; cosmovisão; metáfora; poética.
JOSÉ REVUELTAS Y EL SER NACIONAL MEXICANO: CONTINUIDADES Y MUTACIONES ENTRE LA NOVELA Y EL ENSAYO
Authors: Victory Solange
Published: November 2019

RESUMEN: Este trabajo se propone reflexionar acerca de la congruencia entre el proyecto político-intelectual del escritor mexicano José Revueltas -tal como este se declara en sus ensayos teóricos y en su praxis militante- y sus novelas. Se partirá del diálogo polémico con aquellas interpretaciones que proponen una contradicción entre tales zonas del proyecto creador del autor. Esta problemática será abordada a partir de la lectura, el análisis textual y la comparación de El luto humano, novela de 1943, y “Posibilidades y limitaciones del mexicano”, ensayo de interpretación histórica de 1950. Se hará foco en el modo en que en estos textos aparece, funciona y es puesto en tensión el discurso identificado con la corriente de pensamiento conocida como “filosofía de lo mexicano” o ensayo sobre el “ser nacional mexicano”. Si bien la comparación superficial entre los textos arroja la ya estudiada contradicción entre novela y ensayo “político” que nos interesa analizar aquí, a través de la argumentación del artículo se concluirá por demostrar que tanto en ambos es posible leer una relación de tensión con la corriente de pensamiento conocida como filosofía de lo mexicano, aunque la crítica se emprende de modo diverso en cada género. De esta forma, se demostrará que es posible pensar en una coherencia o una unidad de índole superior entre ambas zonas textuales, unidad ya esbozada por el propio Revueltas a través del concepto de “realismo materialista-dialéctico” como eje para su escritura.Palabras clave: José Revueltas; filosofía de lo mexicano; ensayo; novela; realismo.
ALÉM DO PRINCÍPIO DE INCÊNDIO: A MORTA, DE OSWALD DE ANDRADE
Authors: Caimi Claudia Luiza , Patzlaff Augusto
Published: November 2019

O material disponível à consulta em texto ou imagem pertence à lista de artefatos permitidos pelo poder. São assombrosamente arbitrários e vulneráveis a ataques. A obliteração dos arquivos atinge o registro humano, mas também todas as contradições que ameaçam a sustentação do poder e o descrédito da crença oficial, como diz Susan Buck-Morss, “o que sobrevive nos arquivos faz isso por acaso. O desaparecimento é a regra”. Explodir o continuum, diz Benjamin, propõe uma violência militante por “metáforas terroristas” que perturbem a instituição histórica dominante, possibilitando um resgate da memória distante das convenções oficiais fornecidas pelo poder dos guardiões nacionais. “Flamba tudo nas mãos heroicas do poeta” (2005, p. 237), escreve Oswald na peça A morta quando o Poeta inicia o incêndio. Os mortos presentes e incendiados do País da Anestesia pertencem ao hall da história. Assim, o receio duvidoso em como prestar testemunho à verdade com artefatos transitórios elencado por Susan Buck-Morss encontra uma brecha para diálogo com o texto de Oswald de Andrade, especialmente nesse caso, em A morta: onde o método antropofágico perpassa o passado ressignificando a sua existência. Faz uso da pólvora, do fogo e da fogueira, dinamita a tradição regrada e instituída no país da gramática e em cemitérios mascarados por um aparente abandono.Palavras-chave: Antropofagia; incêndio; memória; instituição; A morta.
JUSTICIA: UNA HERRAMIENTA POLIFACÉTICA EN LAS FICCIONES DEL DELITO
Authors: Hwangpo M. Cecilia
Published: November 2019

Resumen: J. Flores Soto define la justicia como “un valor que tiene por objeto conseguir la paz, el orden, la seguridad y el bien común, mediante la realización de la justicia como supremo valor”. Teniendo en cuenta esta definición, podemos decir que sin los valores, la justicia podría llegar a ser una herramienta multifacética de uso personal, o de un determinado grupo, que se utiliza para lograr su meta o un propósito, como se muestra en nuestro corpus, formado por “Emma Zunz”,  Boquitas pintadas y Operación masacre. Sin embargo, a su vez, podemos darnos cuenta de la complejidad y la dificultad de definir la justicia y su ejercicio en un corpus en el que se ligan cuerpos, engaños, falsificaciones y perspectivas. Por ende, la justicia se representa de manera diversa en la cual se convierte en creencias, venganzas, castigos, simuladores, equilibrios, entre otros.Palabras clave: Rodolfo Walsh, Operación masacre, Jorge Luis Borges, Emma Zunz, Manuel Puig, Boquitas pintadas, delito, justicia, castigo, verdad, creencias.
VIABILIDADE E MÉTODOS PARA SUPERAÇÃO DE DORMÊNCIA E ANÁLISE BIOMÉTRICA DAS SEMENTES DE PUERÁRIA
Authors: Pinheiro Romário De Mesquita , Macedo Vinicius Guilherme Kiesow , Soares Vanessa Nogueira , Tunes Lilian Vanussa Madruga de , Almeida Andréia Da Silva
Published: November 2019

A Pueraria phaseoloides é uma espécie forrageira, de importância na Amazônia devido ao uso na nutrição animal e correção de solo e muito utilizada como cobertura verde, porém esta espécie apresenta altos índices de dormência. A pesquisa foi realizada com o objetivo de verificar a possibilidade de superar a dormência por meio de cinco tratamentos, escarificação com punção, água por 24 horas, água por 8 horas, água a 80 °C por 5 minutos, lixa mais a testemunha, paralelamente, avaliou-se a germinação destas sementes quanto à coloração, estas foram separadas em pretas, vermelha clara, vermelhas escuras e mistas. Para esta finalidade, um lote de sementes de P. phaseoloides, foi submetido a três diferentes formas de avaliação, coloração tegumento, escarificação e caracterização biométrica. Foram realizadas avaliações de germinação quanto à forma de escarificação, germinação pela diferença de coloração do tegumento e caracterização biométrica do lote de sementes, neste foi avaliado, comprimento, largura, espessura e peso da massa fresca das sementes. Observou-se que: a) As sementes quando submetidas às diferentes formas de escarificação, os métodos que se mostraram com melhor potencial de superação de dormência foram os métodos de escarificação mecânica por meio de punção e lixa; b) Quando as sementes foram separadas pela coloração, para verificar em qual coloração as sementes apresentariam maior dormência, notou-se que as sementes de coloração pretas, tiveram um melhor desempenho do que as demais colorações; c) Quanto à avaliação morfométrica das sementes P. phaseoloides, dentre as variáveis analisadas a massa fresca foi a que apresentou maior coeficiente de variação.
Efficiency Of The Process Of Soybean Seed Production In Paraguay
Authors: Prieto José Portillo , Gadotti Gizele Ingrid , Martins Andrea Bicca Noguez , Carvalho Ivan Ricardo , Barbosa Maurício Horbach , Martins Tamires da Silva , Lautenchleger Francine , Lopes Raquel Soares , Lopes Raquel Soares , Villela Francisco Amaral
Published: November 2019

The objective of this work was to evaluate the quality of the seeds produced in Caaguazú Department and to verify improvements in the production, packaging, storage and commercialization systems of the company. The work was carried out in the seed analysis laboratory of the company SEM-AGRO S.A.E., located in the district of Dr. Juan Eulogio Estigarribia, department of Caaguazú, Paraguay. The data were obtained through records implemented by the company's quality management system, which are performed in each company process, from the field to the commercialization. The percentage of planned and approved surface use for seeds is 64.7% in the harvests from 2010/11 to 2013/14. The average yield is 2,826 kg per hectare of seeds. The yield after conditioning is 1,870.5 kg per hectare of seeds, with 68% of use. The quality of the seed adds in the production of off-season in relation to the regular harvest. The sowing is concentrated in two cultivars and has less diversity of cultivars.
Using a Post-Box Strategy to Elicit & Address Student Misconceptions in Biology
Authors: Chan Kam Ho (Kennedy)
Published: November 2019

Students often bring to biology classrooms ideas that are not in line with scientific thought. Simply telling students that their ideas are wrong does not always help advance their scientific thinking. This article describes a teaching and learning activity that allows secondary biology teachers to elicit, interpret, and address students' misconceptions in a meaningful way. The activity provides a chance for students to discuss their nascent ideas about biology with their peers in a safe and nonthreatening environment. More importantly, the activity engages students in a process of reconsidering their initial ideas through reasoning about why certain ideas are scientifically correct.