bluuebunny/crossref_metadata_2025 huggingface dataset:
Reversed-Phase Liquid Chromatography Methods Based on C18 Polymer Monoliths for the Determination of Urinary Myoglobin
Authors: Vitek Renan , do Nascimento Fernando , Masini Jorge
Published: May 2023

This study describes reversed-phase liquid chromatography (RPLC) methods to quantify urinary myoglobin using polymer monolithic columns produced by copolymerization of stearyl methacrylate (SMA) and ethylene glycol dimethacrylate (EDMA). The columns were prepared in the coffins of 1.5 mm internal diameter (i.d.) ethylene tetrafluoroethylene (ETFE) tubing for use in sequential injection chromatography (SIC) and solid phase extraction (SPE), and inside 1.0 mm i.d. Silcosteel® tube for use in narrow-bore liquid chromatography. The monoliths inside the ETFE were produced via UV, whereas thermal polymerization formed the monoliths inside the Silcosteel® tube. The separation of carbonic anhydrase, lysozyme, and myoglobin was demonstrated because they may occur simultaneously in urine samples. Quantification was undertaken by external calibration, and the accuracy was evaluated by the spiking/recovery strategy. The methods exhibited linearity from 5.0 to 60 µg mL-1 (SIC), 2.5 to 50 µg mL-1 (high-performance liquid chromatography (HPLC)), and 1.0 to 7.5 µg mL-1 for an SPE-HPLC method. The lowest limits of detection and quantifications were 0.13 and 0.43 µg L-1, respectively, obtained after concentrating myoglobin by SPE. Recoveries ranged from 98 to 105%. The low cost, simplicity, reusability, and analytical features provided by these polymeric stationary phases make them affordable alternatives to routine analyses of urinary myoglobin.
BI-DIRECTIONAL APPROACH TO ANALYZING DIALOGICAL SPEECH IN JOHN STEINBECK’S NOVELS
Authors: Andreeva Ekaterina G. ,   St. Petersburg State University, Grebenuyk Andrey ,   St. Petersburg State University
Published: May 2023

The paper presented aims at linguistic and stylistic analysis of the direct speech of fictious characters along with the examination of some pragmalinguistic features of the communicative situation as such. Language-based approach can be viewed as an ‘enquiry going from the text to the characters’, while pragmatic analysis unfolds in the opposite direction, ‘from the pragmatic intentions to the literary text’. Such a ‘dualistic’ approach can bring to light the correlation between communicative situations portrayed in novels and specific stylistic/textual characteristics of the dialogue. Besides that, it helps to unveil the author’s idea and message of a book. Therefore, the primary aim of the paper is to reveal the interrelation between the pragmatic parameters of a communication situation and stylistic/textual features of a dialogue. The methods used are pragmalinguistic analysis of communicative situations, linguistic analysis of the characters’ speech with the elements of stylistic analysis. The application of the bi-directional approach is demonstrated on the material of dialogues from John Steinbeck’s books.
IMPLEMENTING CLIL TECHNOLOGY IN THE CONTEXT OF SUPPLEMENTARY EDUCATION FOR SECONDARY SCHOOL STUDENTS AT A TECHNICAL UNIVERSITY
Authors: Arkhipova Elena I. ,   Kalashnikov Izhevsk State Technical University, Kamasheva Olga A. , Repina Tatiana Yu. , Somova Kseniia D. ,   Kalashnikov Izhevsk State Technical University,   Kalashnikov Izhevsk State Technical University,   Kalashnikov Izhevsk State Technical University
Published: May 2023

The article describes experience of implementing supplementary educational programmes for secondary school students using CLIL technology at a technical university. CLIL technology is viewed as an integrating tool to develop a set of competences necessary for Learner-Centred Continuing Education of future specialists in the framework of supplementary educational programmes. The paper provides analysis of theoretical prerequisites and practices for the use of Content and Language Integrated Learning Technology in foreign language education. It shows opportunities of integrating them into the supplementary educational process at a technical university in “the secondary school — higher school interaction” context. The subject, metasubject and personal characteristics of the attainment targets of the training programmes are addressed. The article presents the results of the technology approbation attached to the implementation of supplementary educational programmes for secondary school students at Kalashnikov ISTU.
THE ROLE OF LEXICAL MEANS TO CREATE EXPRESSIVENESS IN THE LANGUAGE OF ADVERTISING ON THE INTERNET
Authors: Makarycheva Anna V. ,   Moscow State Institute of International Relations (University), Kuznetsova Natalya I. ,   Moscow State Institute of International Relations (University)
Published: May 2023

This article is devoted to the study of lexical means to create expressiveness in the language of advertising on the internet. Researchers express an abiding interest in this topic. However, the emphasis is mainly placed either on certain means of advertising, or on a specific part of speech. The purpose of this study is to consider the ways in which different parts of speech (i.e., nouns, verbs, adjectives, numerals, pronoun and adverbs) are used in internet advertising slogans. The paper takes on the following tasks: addressing the vast empirical data in the area of research and applying it as a basis for our study; determining the functions of different parts of speech in a sentence; identifying how frequently they are used; and establishing the degree of their expressiveness in advertising, which is considered to be of paramount importance when attracting the attention of potential buyers. The material for the present study was selected from Spanish- and English-language websites covering the period from 2012 to 2021. The research methods include comparison, synthesis and analysis of data, as well as comprehensive semantic analysis. General tendencies in the use of specific parts of speech are supported by concrete examples, which totalled several hundred. The results of the study allow us to conclude that different parts of speech are applied to create a vivid and memorable advertisement and fulfil not only a semantic, but also a stylistic and expressive function. Apart from this, with a view to creating greater expressiveness, the considered means are combined with visual images, which enhances their impact on the consumer of advertising.
THE ROLE OF TRANSLATION ANALYSIS IN TEACHING POETRY TRANSLATION
Authors: Obolenskiy Alexey A. ,   Peoples’ Friendship University
Published: May 2023

This article focuses on the role of translation analysis and its use in the learning of poetry translation in the education of translators. A future translator needs not only to learn how to translate a text correctly from one language to another, but also to understand the whole process of implementing the task. This is a necessary factor because translating poetry is one of the most difficult types of translation. The aim of our study is to identify and establish the role of translation analysis in the translation of poetic works, and to elaborate methodological guidelines for its use in classes to teach poetry translation. The author considers the problems of translation of poetic works and provides a theoretical basis for translation analysis. As a consequence, the article highlights the positions of different Russian academics on the concept of “translation analysis” and provides a gradual analysis of the phases of the process. From these findings, it was concluded that translation analysis is important and necessary for translating any kind of poetic text, and a suggested list of recommendations for working with a foreign text step by step using translation analysis was drawn up.
EVALUATIVE SEMANTICS OF GENDER-MARKED PAREMIAS THAT EXPLICATE STEREOTYPES (BASED ON ENGLISH AND RUSSIAN PROVERBS)
Authors: Shaimardanova M. R. ,   Kazan (Volga Region) Federal University, Akhmetova Leisan A. ,   Kazan (Volga Region) Federal University
Published: May 2023

The purpose of the study is to identify ways to represent ethno-cultural concepts of value, stereotypical assessments in relation to representatives of a particular sex by conducting a comparative analysis of gender-marked English and Russian proverbs. The following research methods are used in the article: the method of scientific observation, the comparative method, the descriptive method, the method of quantitative counting. The scientific novelty of the study lies in a comprehensive comparative analysis of the evaluative semantics of English and Russian proverbs representing gender stereotypes. As a result, the following aspects are highlighted and characterized: semantic groups of proverbs containing a gender nomination that most clearly represent the evaluative gender stereotypes of the societies under study; general and specific characteristics of evaluative semantics of paremias; evaluative ideas of ethnic groups about members of the sexes, broadcasted through proverbs with a gender component.
THE FUNCTIONING OF RELATIVE PRONOUNS QUI AND QUE IN FRENCH SENTENCES
Authors: Shumkov Andrei A. ,   St. Petersburg Electrotechnical University “LETI”, Fatullaeva Anna O. ,   St. Petersburg Electrotechnical University “LETI”
Published: May 2023

The article describes the study of the main characteristics of relative pronouns qui/que and considers the actualization of their functions in the French sentence. The aim of this study is to analyze the peculiarities of qui/que pronouns functioning both as independent units and as a part of the antecedent complexes ce qui/ce que. The examples of interrogative constructions demonstrate how pronouns qui and que actualize the difference in their informativeness, which influences the degree of explicitness or inexplicitness of the subject in simple and compound sentences. The authors conclude that the relative pronoun qui, being the most informative, marks the presence of the inexplicit, least informative subject; que, being the least informative, marks the presence of the explicit, most informative subject. A comparison of the properties of qui/que units within the framework of different sentence types establishes the difference in their function. The use of qui/que in the declarative provides the possibility to use both an animate and an inanimate antecedent, while the actualization of the independent nominative function in the interrogative sentence limits the use of qui to an animate antecedent, que — to an inanimate one. This comparison proves that the opposition to the function relative pronouns perform is considered to be the most important at the present stage of the development of the French language and enables them to be either the subject (qui) or the complement (que) within a sentence. The usage of qui/que pronouns with some intensional verbs is also considered. It has been revealed that the use of the pronoun qui provides more options for the characterization of the subject due to the possibility of using both the indicative and subjunctive moods while the use of que in this context entails changes in the sentence structure and the type of the subordinate relation: the desired characteristics can be expressed only by the usage of the subjunctive mood.
Implicit administrative acts. Part one
Authors: Andreev Denis S. ,   Siberian Federal University,   Reshetnev University
Published: May 2023

Based on the comparative legal method, the article analyzes the use of the construction of implicit (fictitious) decisions in Russian and several European legal orders, when the inaction of the public administration is equated with the adoption of an administrative act. In the first part of article the author provides a brief overview of the evolution of the legal regulation of the silence of public administration in France, the Netherlands and Germany, and considers the influence of the Directive 2006/123/EC of the European Parliament and of the Council of December 12, 2006 on services in the internal market (Services Directive) on the development of the institution of implicit decisions in the EU countries. The paper analyses the conceptual basis and the main arguments pro et contra of two models of implicit administrative acts — a negative decision (based on the principle of “silence is a sign of refusal”) and a positive decision (based on the principle of “silence is a sign of consent”). Despite political slogans and formal proclamation in legislation, in fact, a mixed model is implemented in European national legal systems, combining both principles. The functional meaning of implicit administrative acts has undergone a significant evolution. The initial purpose of this construction was to provide the possibility of appealing against the inaction of public authorities in those legal acts that allowed judicial review only of administrative acts. In the future, the construction of implicit administrative acts began to be used as a tool for increasing the efficiency of public administration, simplifying and speeding up administrative procedures, and stimulating economic activity.
Restrictive covenants in agreements between entrepreneurs and their employees under the law of foreign countries. Part one: United Kingdom and United States of America
Authors: Chukreyev Andrey A. ,   Tyumen State University
Published: May 2023

This review article is devoted to restrictive covenants, which are widely used in contracts between entrepreneurs and their employees in many countries. In Russia, these covenants are not supported by the courts. It is believed that such restrictions are contrary to the constitutional and other norms of Russian law. The purpose of this study is to analyze the foundations of legal regulation in a number of countries of such restrictive covenants as non-competition agreements, non-solicitation agreements, non-dealing agreements and non-disclosure agreements. This analysis is necessary for a reasonable answer to the question of the advisability of recognizing in Russia the legality of such agreements. The first part of this article provides an overview of the law on non-competition and other similar covenants of the United Kingdom and the United States, in the second part — Germany, France, Japan, China and the Eurasian Economic Union (EAEU). Due to the particularly widespread distribution of such covenants in the United States, the analysis of the foundations of their legal regulation in this country is central to the present study. In jurisdictions where non-competition agreements and other similar restrictive covenants are not prohibited, the “rule of reason” acts as a legal mechanism for balancing the competing interests of employers, employees and public interests. This rule allows the courts in each specific dispute to assess the specified conditions for their compliance with the protected business interest of the employer and other criteria. The conclusion is made about the advisability of legalizing agreements on non-competition, non-engagement and non-entrepreneurship in Russia, taking into account the positive foreign experience of legal regulation in this area. In this regard, it will be necessary to legislate in Russian law an analogue of the rule of reason.
Social parents and social upbringing of a child in legal discourse
Authors: Komissarova Elena G. ,   Perm State National Research University
Published: May 2023

The article presents the author’s judgments about such a “manifest” concept for the family legal reality as social parents. In the status of a theoretical construction, it is often included in legal discourse, but the sign of sociality accompanying it is deprived of proper analysis by family law science. Interpreting sociality in the context of social reality, each author sees in it his own hypothesis of social (kinship, parent, child rearing). This approach has led to a significant scientific omission, concluded in the fact that the child-parent branch of family law includes counterterrorism, which has no connection and an understandable relationship with the concept of “persons recognized by parents at the direction of the law”. The correlation of the concept of “social parents” with such concepts of this series looks no less vague: the rights and obligations of parents; persons replacing parents; other persons in whose care the child is. The conclusions of the article reflect the author’s scientific views on the problem posed by him and consist in the following: the presence of obvious social grounds for the introduction of new parental concepts into the space of family law should not harm the academic maxim about the inadmissibility of separating existing legislation. Following the goal of strengthening its integrity and internal logic, the doctrine will have to identify social parents in the space of law not only from the standpoint of the usefulness of their social role, but also in the sense of correlation with already known normative constructions; scientific success in cognizing the semantic essence of the theoretical construction “social parents” can be achieved provided that cognition is not organized as an autonomous problem that exists “by itself ”, but in connection with the existing legal knowledge about parents “by law”; in the doctrinal construction of “social parents”, a significant theoretical resource is reserved, which is able to make such latent legal concepts as the actual father/mother, stepfather/stepmother, and actual educator scientifically relevant.
Editorial Introduction to “Current and Future Directions in TESOL Studies”
Authors: Baker John R. ,   Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Published: May 2023

I am delighted to present this special issue of the Rupkatha Journal of Interdisciplinary Studies in Humanities, titled Current and Future Directions in TESOL Studies. This issue brings together manuscripts authored by a diverse community of academics, researchers, teachers, graduate students, and TESOL professionals from across the globe to share an inclusive range of research findings, experiences, and practical and theoretical issues that celebrate the multifaceted nature of our field. This ongoing exchange is a global imperative as it underscores the importance of language and learning in fostering understanding and cooperation, thus bridging gaps between individuals and communities. In a world often fragmented by language, culture, and politics, communication across these divides is more critical than ever. As such, I am particularly pleased to note that the articles featured in this edition resonantly contribute to the furtherance of this goal.
A Sociolinguistic Analysis of Newspaper Coverage and Reader Response to Covid-19 Reports
Authors: Cookey Ibiere ,   Department of Mass Communication, University of Nigeria, Nsukka, Ukonu Michael O. , Orekye Emeka S. , Mgboji Olanrewaju ,   Department of Mass Communication, University of Nigeria, Nsukka,   Department of Mass Communication, University of Nigeria, Nsukka,   Department of Mass Communication, University of Nigeria, Nsukka
Published: May 2023

Studies attest to the importance of official languages in health communication in multilingual societies. However, the challenge lies in using an official language in ways that enable both majority and minority language speakers to identify with their sociocultural orientations when using a lingua franca. With the emergence of Covid-19, this challenge has come to the forefront following surveys on citizen responses to health messages. The study examines the themes, narrative viewpoints, language modes of newspaper reports on Covid-19, and reader responses to these reports. We aim to determine the implications of reader response on the credibility, severity, and transmissibility of Covid-19. The contents of three Nigerian newspapers (The Guardian, Punch, and Premium Times) were analyzed using quantitative and discourse analysis. The results showed that the themes of newspaper reports focused on challenges, progress made, preparedness, and containment measures. The language mode was predominantly negative, using fear appeals. Audience responses followed the same themes as the newspapers but demonstrated a remarkable shift in narrative viewpoint and language mode, which in Nigerian style English indicated low source credibility, ethnic divisions, and the denial of the severity and transmissibility of Covid-19. Readers’ responses to newspaper coverage of Covid-19 reinforce the view among scholars that trust in information sources is linked to attitudes toward health risks.
Liquid Smoke from Teak Leaves as Pestiside to Control Whiteflies
Authors: Kaffah Elsyaff Visshilmi ,   Universitas Pembangunan Nasional ", Kusuma Meidina Rafida , Siswati Nana Dyah , Erliyanti Nove Kartika ,   Veteran",   Jawa Timur
Published: May 2023

Jati merupakan salah satu tanaman yang banyak dijumpai di Indonesia. Daun jati memiliki komponen lignin, selulosa, dan hemiselulosa yang dapat diurai menjadi fenol dan asam dalam bentuk cairan, disebut asap cair, dengan proses pirolisis yang bermanfaat sebagai pestisida nabati. Tujuan dari penelitian ini adalah untuk membuat asap cair dari limbah daun jati kering dengan metode pirolisis, mencari temperatur dan waktu relatif baik untuk memperoleh kadar fenol dan asam relatif baik dalam asap cair, dan menguji keefektifan asap cair sebagai pestisida nabati untuk hama kutu putih. Proses yang digunakan dalam penelitian ini yaitu pirolisis dengan tahapan karbonisasi lalu dilanjutkan dengan tahap kondensasi agar didapatkan asap cair. Proses pirolisis dilakukan dengan variasi temperatur (°C) 200, 250, 300, 350, dan 400 serta waktu proses pirolisis (jam) 1, 1 ½, 2, 2 ½, dan 3. Diperoleh asap cair relatif baik pada suhu 350°C dan waktu 3 jam karena memiliki kandungan fenol dan asam tertinggi yang masih sesuai dengan SNI, yaitu fenol sebesar 1,915% dan asam sebesar 14,885%. Asap cair relatif baik dilakukan uji keefektifan untuk menghilangkan hama kutu putih dengan konsentrasi 20% dan didapatkan hasil bahwa asap cair relatif baik efektif menghilangkan hama kutu putih dalam kurun waktu sembilan hari
What is the role of the infringement procedure in tackling rule of law backsliding in the EU?
Authors: Martins de Matos Gonçalo
Published: May 2023

The rule of law is a foundational and fundamental value of the European Union, embodied by the complete and coherent system of legal remedies based on the fundamental right to effective judicial protection. In some Member States, the rule of law has been facing challenges and difficulties of varying degrees of severity, leading to what has been called a “rule of law backsliding” in those States. The urgency to tackle these challenges has led to the search for immediate solutions within the European Union’s tools and mechanisms, which has increased the focus given to the infringement procedure, a judicial procedure whose goal is to review the behaviours of Member States and find breaches of European Union law committed by them. The past uses of this judicial mechanism by the European Commission and the decisions of the Court of Justice of the European Union (“CJEU”) that followed have showed positive results and opened promising paths to follow in the fight to uphold the rule of law in the European Union
How can there be an ecological transition without a just transition? – starting with the European Union
Authors: Machado Nataly
Published: May 2023

Understanding that the nations and nation states that have historically contributed the least to climate change suffer the most from its impacts and have fewer opportunities to protect themselves or adapt to them is the first step in the process of understanding the importance of a just and inclusive transition for all. In an immense diversity of realities, this very notion is no different in the context of the European Union. This article seeks to show the need to find concrete tools, through the European Union’s protagonism, for an ecological transition with social justice.
The crisis of the Common European Asylum System: rethinking solidarity in light of Human Rights
Authors: Di Nunzio Paola
Published: May 2023

In 2015, the unprecedented arrival of refugees and irregular migrants in the European Union (EU) put a strain on the Common European Asylum System (CEAS), thus exposing a number of deficiencies in EU external border, asylum and migration policy. The need to reform the system became urgent and the EU was presented with both a challenge and an opportunity to further advance towards a much-needed consensual and long-term solution for the harmonisation of the asylum system, standing on the basis of solidarity and responsibility-sharing. This paper argues that the new comprehensive approach to migration and asylum praised by the European Commission (EC) is still missing in the recent Pact on Migration and Asylum of 2020, which represents more a missed opportunity than the real reform that the CEAS needs. The chosen legislative path, the dualistic understanding concerning the approach to migrants, and the new solidarity mechanism envisioned in the Pact show how the lack of consensus among Member States, the tendency towards the creation of a “Fortress Europe”, and an asymmetric idea of inter-state solidarity prevail, preventing the development of a common European framework for migration management that is both effective and in line with the EU’s values and objectives. This paper further argues that, if the EU fails to shift the paradigm of solidarity, the system is at risk of remaining fractured and incapable of withstanding the future challenges of migration. A new framework must be grounded on the principle of solidarity, as defined in the Article 80 of the Treaty on the Functioning of the European Union (TFEU) which, in turn, needs to move from a state-centred approach to a concept of solidarity based on affected individuals, thus setting its foundations on a human rights basis. The EU needs, in fact, to strongly step up as a humanitarian actor and place protection and responsibility-sharing at the centre of its agenda: the protection of fundamental human rights in its territory and beyond is at stake.
Trans rights in the European Union – “sex” v. “gender” on the path towards equality and non-discrimination
Authors: Cardoso Ana
Published: May 2023

Equality and non-discrimination are two of the most important foundational values of the European Union. But a rapidly evolving society means that their practical application has to be constantly under review to assess if their content and objectives are being fulfilled. When it comes to the rights of the LGBTIQ community – here in particular of trans when compared with cis women – there is still a long way to go to effectively safeguard them, while reasonably protecting all involved. Terminological confusion around the concepts of “sex” and “gender” has served to justify the curtailment of the fight for equality and non-discrimination, and relegate trans women to a position of second-class citizens. The EU needs to review its approach to this particular issue and enshrine into law the concepts of “sex” and “gender” as a way to continue to push forward in its fight for LGBTIQ rights, doing justice to its moniker of “rainbow Europe”.
The use of e-learning in universities during the Covid-19 pandemic: An institutional theory perspective
Authors: Wicaksono Aditya Pandu , Kusuma Hadri , Mahfuroh Riana
Published: May 2023

The Covid-19 pandemic has forced universities to change learning methods from face-to-face learning to online learning. This study aims to determine the effect of institutional pressure (coercive, mimetic, and normative) on the use of online learning in universities. This study uses a quantitative approach with a total sample of 357 respondents consisting of 42 lecturers and 315 university students in Yogyakarta and Central Java. This research employs an online questionnaire as a data collection media. The questionnaires were distributed and filled out by respondents from September 2020 to February 2021. The research shows interesting findings because pressure from regulators (coercive) is not a significant predictor of e-learning use. Whereas mimetic and normative pressures have a positive and significant effect on e-learning. This study also categorizes the findings into two groups i.e., lectures and students. Students assume that coercive, mimetic, and normative significantly pressure universities to use online learning. Whereas the lecturers think that the pressure from the regulator has no significant effect because health issues are the main priority. This study contributes to the literature by providing empirical evidence on the acceptance of e-learning technology during the Covid-19 pandemic.
An eHealth App (CAPABLE) Providing Symptom Monitoring, Well-Being Interventions, and Educational Material for Patients With Melanoma Treated With Immune Checkpoint Inhibitors: Protocol for an Exploratory Intervention Trial (Preprint)
Authors: Fraterman Itske , Wollersheim Barbara M , Tibollo Valentina , Glaser Savannah Lucia Catherina , Medlock Stephanie , Cornet Ronald , Gabetta Matteo , Gisko Vitali , Barkan Ella , di Flora Nicola , Glasspool David , Kogan Alexandra , Lanzola Giordano , Leizer Roy , Mallo Henk , Ottaviano Manuel , Peleg Mor , van de Poll-Franse Lonneke V , Veggiotti Nicole , Śniatała Konrad , Wilk Szymon , Parimbelli Enea , Quaglini Silvana , Rizzo Mimma , Locati Laura Deborah , Boekhout Annelies , Sacchi Lucia , Wilgenhof Sofie
Published: May 2023

BACKGROUND

Since treatment with immune checkpoint inhibitors (ICIs) is becoming standard therapy for patients with high-risk and advanced melanoma, an increasing number of patients experience treatment-related adverse events such as fatigue. Until now, studies have demonstrated the benefits of using eHealth tools to provide either symptom monitoring or interventions to reduce treatment-related symptoms such as fatigue. However, an eHealth tool that facilitates the combination of both symptom monitoring and symptom management in patients with melanoma treated with ICIs is still needed.

OBJECTIVE

In this pilot study, we will explore the use of the CAPABLE (Cancer Patients Better Life Experience) app in providing symptom monitoring, education, and well-being interventions on health-related quality of life (HRQoL) outcomes such as fatigue and physical functioning, as well as patients’ acceptance and usability of using CAPABLE.

METHODS

This prospective, exploratory pilot study will examine changes in fatigue over time in 36 patients with stage III or IV melanoma during treatment with ICI using CAPABLE (a smartphone app and multisensory smartwatch). This cohort will be compared to a prospectively collected cohort of patients with melanoma treated with standard ICI therapy. CAPABLE will be used for a minimum of 3 and a maximum of 6 months. The primary endpoint in this study is the change in fatigue between baseline and 3 and 6 months after the start of treatment. Secondary end points include HRQoL outcomes, usability, and feasibility parameters.

RESULTS

Study inclusion started in April 2023 and is currently ongoing.

CONCLUSIONS

This pilot study will explore the effect, usability, and feasibility of CAPABLE in patients with melanoma during treatment with ICI. Adding the CAPABLE system to active treatment is hypothesized to decrease fatigue in patients with high-risk and advanced melanoma during treatment with ICIs compared to a control group receiving standard care. The Medical Ethics Committee NedMec (Amsterdam, The Netherlands) granted ethical approval for this study (reference number 22-981/NL81970.000.22).

CLINICALTRIAL

ClinicalTrials.gov NCT05827289; https://clinicaltrials.gov/study/NCT05827289

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/49252
Usability Assessment Methods for Mobile Apps for Physical Rehabilitation: Umbrella Review (Preprint)
Authors: Hach Sylvia , Alder Gemma , Stavric Verna , Taylor Denise , Signal Nada
Published: May 2023

BACKGROUND

Usability has been touted as one determiner of success of mobile health (mHealth) interventions. Multiple systematic reviews of usability assessment approaches for different mHealth solutions for physical rehabilitation are available. However, there is a lack of synthesis in this portion of the literature, which results in clinicians and developers devoting a significant amount of time and effort in analyzing and summarizing a large body of systematic reviews.

OBJECTIVE

This study aims to summarize systematic reviews examining usability assessment instruments, or measurements tools, in mHealth interventions including physical rehabilitation.

METHODS

An umbrella review was conducted according to a published registered protocol. A topic-based search of PubMed, Cochrane, IEEE Xplore, Epistemonikos, Web of Science, and CINAHL Complete was conducted from January 2015 to April 2023 for systematic reviews investigating usability assessment instruments in mHealth interventions including physical exercise rehabilitation. Eligibility screening included date, language, participant, and article type. Data extraction and assessment of the methodological quality (AMSTAR 2 [A Measurement Tool to Assess Systematic Reviews 2]) was completed and tabulated for synthesis.

RESULTS

A total of 12 systematic reviews were included, of which 3 (25%) did not refer to any theoretical usability framework and the remaining (n=9, 75%) most commonly referenced the ISO framework. The sample referenced a total of 32 usability assessment instruments and 66 custom-made, as well as hybrid, instruments. Information on psychometric properties was included for 9 (28%) instruments with satisfactory internal consistency and structural validity. A lack of reliability, responsiveness, and cross-cultural validity data was found. The methodological quality of the systematic reviews was limited, with 8 (67%) studies displaying 2 or more critical weaknesses.

CONCLUSIONS

There is significant diversity in the usability assessment of mHealth for rehabilitation, and a link to theoretical models is often lacking. There is widespread use of custom-made instruments, and preexisting instruments often do not display sufficient psychometric strength. As a result, existing mHealth usability evaluations are difficult to compare. It is proposed that multimethod usability assessment is used and that, in the selection of usability assessment instruments, there is a focus on explicit reference to their theoretical underpinning and acceptable psychometric properties. This could be facilitated by a closer collaboration between researchers, developers, and clinicians throughout the phases of mHealth tool development.

CLINICALTRIAL

PROSPERO CRD42022338785; https://www.crd.york.ac.uk/prospero/#recordDetails
Aplikasi Pupuk NPK Pada Tanaman Bawang Merah di Kabupaten Cirebon
Authors: Hamdani Kiki Kusyaeri , Susanto Heru , Nurawan Agus , Rodhian Saiful , Rahayu Sarwendah Puji
Published: May 2023

Pemupukan merupakan pemberian hara diantaranya ke dalam tanah untuk mendukung pertumbuhan dan perkembangan tanaman bawang merah. Saat diaplikasikan, penggunaan pupuk NPK majemuk lebih praktis dibandingkan pupuk tunggal. Penelitian ini bertujuan untuk menguji pengaruh pupuk NPK majemuk terhadap hasil tanaman bawang merah di Kecamatan Pabuaran, Kabupaten Cirebon. Penelitian dilaksanakan di lahan sawah irigasi, Desa Pabuaran Lor, Kecamatan Pabuaran, Kabupaten Cirebon pada bulan Juni sampai September 2019. Penelitian menggunakan Rancangan Acak Kelompok Lengkap (RAKL) dengan sembilan perlakuan dan tiga ulangan. Setiap perlakuan terdiri dari dosis pupuk NPK (NPK 16-16-16 dan NPK 15-9-20) dan waktu aplikasinya. Data dianalisis dengan sidik ragam dengan uji lanjut Duncan Multiple Range Test pada taraf kepercayaan 95%. Hasil penelitian menunjukkan bahwa hasil bawang merah per hektar paling tinggi diperoleh pada perlakuan pupuk NPK 16-16-16 dengan dosis 650 kg ha-1 (350 kg ha-1 umur 0 HST dan 300 kg ha-1 umur 15 HST) dan NPK 15-9-20 dengan dosis 300 kg ha-1 (150 kg ha-1 umur 15 HST dan 150 kg ha-1 umur 35 HST) yaitu 22,60 ton ha-1 sedangkan bobot umbi per tanaman paling tinggi dihasilkan oleh perlakuan pupuk NPK 16-16-16 pada dosis 650 kg ha-1 (250 kg ha-1 umur 10 HST, 200 kg ha-1 umur 15 HST, dan 200 kg ha-1 umur 35 HST) dan NPK 15-9-20 pada dosis 200 kg ha-1 (100 kg ha-1  umur 25 HST dan 100 kg ha-1 umur 35 HST). terbaik diperoleh pada perlakuan pupuk NPK 16-16-16 dengan dosis 650 kg ha-1 (250 kg ha-1 umur 10 HST, 200 kg ha-1 umur 15 HST, dan 200 kg ha-1 umur 35 HST) dan NPK 15-9-20 pada dosis 200 kg ha-1 (100 kg ha-1 umur 25 HST dan 100 kg ha-1 umur 35 HST) dengan hasil yaitu bobot umbi per tanaman sebesar 68,67 g.
Karakterisasi Morfologi Pisang di Kabupaten Kampar Provinsi Riau
Authors: Sari Putri Lukmana , MS Zulkifli , Hardi Noer Arif , Akbar Daru
Published: May 2023

Pisang (Musa spp.) merupakan buah paling penting di hampir setiap negara termasuk Indonesia. Pisang  juga merupakan tanaman penting di dunia dan sumber pendapatan di banyak negara berkembang. Keanekaragaman pisang setiap daerahnya memiliki keunggulan masing-masing. Informasi terkait keragaman genetik tanaman sangat penting karena keragaman genetik yang tinggi merupakan salah satu kunci sukses dalam pengembangan tanaman. Terutama dalam penyediaan informasi pemuliaan tanaman. Bahan yang digunakan dalam penelitian ini sebanyak 6 aksesi pisang. Setiap spesies terdiri atas 3 individu yang diperoleh dari hasil eksplorasi di Kabupaten Kampar Provinsi Riau. Alat yang digunakan dalam penelitian ini antara lain adalah stapler, alat tulis, kertas label, kamera, dan penggaris. Pengamatan dan pertelaan morfologi mengikuti Musa Descriptor List. Deskripsi morfologi karakter kualitatif dari 6 populasi pisang telah berhasil didapatkan dan telah disajikan di dalam pembahasan. Hubungan kekerabatan berdasarkan penanda morfologi menggunakan 30 karakter kualitatif menunjukkan koefisien kemiripan genetiknya berkisar antara 0,28-0,60 yang terbagi dua yaitu Klaster A (A1; Pisang 40 Hari, Barangan Medan, Cavendish, Lilit, A2; Ambon) dan B (Pisang Kepok Taiwan). Perbedaan jenis pisang yang tumbuh menunjukkan pisang di Kabupaten Kampar memiliki keragaman morfologis yang cukup tinggi. Pengelompokan pisang pada penelitian ini dipengaruhi oleh persamaan karakter yang dimiliki oleh setiap aksesi yang pada akhirnya mengelompok berdasar persamaan spesiesnya. Dari penelitian ini, diharapkan dapat mengetahui keanekaragaman genetik dan hubungan kekerabatan pisang yang tumbuh di Kabupaten Kampar untuk nantinya akan didapatkan tetua pisang yang bagus sebagai bahan persilangan dan menghasilkan pisang yang potensial di masa mendatang.
Spatio Temporality and Subjectivity in James Joyce's ‘Araby’
Authors: Samanta Anik
Published: May 2023

This paper looks briefly at the configuration of spatio-temporality and subjectivity in James Joyce’s short story ‘Araby’ from the thematic perspective of courtly love and chivalric romance and through Mikhail Bakhtin’s concept of the chronotope and elements of Heideggerian phenomenology and Lacanian psychoanalysis.
Characteristics of Antibiotic-resistant E. coli Isolated from Perfume River in Hue City, Vietnam
Authors: Tram Ngo Viet Quynh , Thuy Phung Thi Thu , Khoa Nguyen Thi Dang , Tuyen Nguyen Thi , Cam Pham Thi Hong , Huong Ngo Thi Dieu , Tri Ton That Canh , Bach Nguyen Hoang , Paglietti Bianca
Published: May 2023

Antibiotic resistant bacteria (ARB) in aquatic environments is attracting increasing attention. However, the spread of ARB along Perfume River in Hue City is poorly understood. This study aimed to phenotypically and genotypically characterize β-lactam- and fluoroquinolone-resistant Escherichia coli isolates from this river. Water samples were collected from the urban, rural, agricultural, and less-affected areas in March 2020. E. coli susceptibility to seven commonly employed antibiotics was analyzed using the disk diffusion method, and the antibiotic resistance genes (ARGs), qnrA, qnrB, qnrS, TEM, SHV, and CTX-M, were identified using polymerase chain reaction (PCR) and DNA sequencing. The antibiotic susceptibility patterns of E. coli revealed that the rate of amoxicillin resistance was the highest (60%). PCR assays and sequencing of 12 β-lactam-resistant E. coli isolates indicated the presence of blaTEM and blaCTX-M-15 in 58.3% and 16.7% of the isolates, respectively. Only one of four fluoroquinolon -resistant E. coli isolates harbored the qnrS, while qnrA or qnrB genes were not detected. These findings suggest that this water may be an essential source of transmissible ARGs in Hue City, which may have a detrimental impact on the people living in this area.
Seroprevalence of Hepatitis E Antibodies in Asymptomatic Antenatal Women from Tertiary Care Centre, Puducherry
Authors: Riyaz Mohammed , Umadevi S. , Pramodhini S. , Easow Joshy M.
Published: May 2023

Hepatitis E virus (HEV) is the most common cause of AVH in developing countries. HEV causes a self-limiting infection that is transmitted mainly through the consumption of contaminated food and water. Our study aimed to find out the seroprevalence of HEV infection. Detected both IgG & IgM antibodies from 100 asymptomatic antenatal women. ELISA (DIA PRO, Italy) was used to detect antibodies. Seropositivity was found in 9% of pregnant women, all might have been exposed to HEV infection previously. It could be unnoticed due to its self-limiting nature. IgG was 5% and IgM was 6%. Both IgM & IgG were detected in two pregnant women. Untreated water was used by the majority of women irrespective of their educational status. Though it is a self-limiting disease, it is necessary to screen for its antibody. Awareness about the modes of transmission & complications needs to be addressed in the community. It is necessary to do further studies for screening for HEV infection as there is a very limited number of studies published from South India.
Comparison of 16S rRNA Gene Quantification with Selected Inflammatory Markers and Culture Method in Septic Arthritis
Authors: Al-Masoodi Rana Abdulrahman Hamood , Abdullah Uday Younis Hussein , Tengku Mohd Shihabudin Tengku Muzaffar Bin , Solong Ahmad Fadzli Bin , Ismail Salwani Binti , Harun Azian
Published: May 2023

This study aims to determine the types of causative organism, the utility of synovial procalcitonin (PCT), C-Reactive Protein (CRP) and bacterial 16S rRNA gene-based RT-PCR and their comparison with conventional culture results in patients with clinically-suspected SA. A total of 38 patients were recruited in this cross-sectional study for performing synovial PCT and CRP assay, and bacterial gDNA quantification via RT-PCT. Records of culture results, WBC count, ESR, blood CRP, and antibiotic administration were obtained. Gross appearance and viscosity determination are significantly associated with the bacterial load. This study documents Acinetobacter radioresistens and Klebsiella pneumoniae bacteria as causative pathogens of SA in Malaysia. CRP and ESR showed a significant role in diagnosing SA. Reasons for finding no concordance between conventional culture methods and 16S rDNA RT-PCR as well as synovial PCT were comprehensively reviewed. Gross appearance and viscosity showed a significant relationship with the bacterial load. RT-PCR is useful in patients treated with antimicrobial therapy with negative culture results.RT-PCR has speed and accuracy compared to conventional culture. Awareness of Klebsiella pneumoniae and Acinetobacter radioresistens as causative bacteria should be prompted among clinicians particularly at local, regional as well as international levels. Developing guidelines for including 16S rRNA gene RT-PCR and introducing Digital PCR and next-generation sequencing to detect and identify bacterial species in diagnosing SA is recommended.
Deciphering Azadirachta indica (Neem) Gum Microbiome using Metagenomic Approaches
Authors: Saxena Pragya , Singh Arjun , Chakdar Hillol , Shirodkar Sheetal , Srivastava Alok K.
Published: May 2023

Indian lilac or neem (Azadirachta indica) is found in tropical and subtropical regions of the Indian subcontinent. Each part of the tree is a source of various phytochemicals. Neem gum is an exudate from mature parts of the plant stem. Biochemically, it has an acidic pH range (5–6) and is composed of monosaccharides, saponins, phenols, and tannins. This study aimed to elucidate the diversity of neem gum-associated microflora through high throughput metagenomics approach using 16S rRNA variable region sequencing. The bacterial community of neem gum was dominated by Firmicutes (~82%), Proteobacteria (~18%), and Actinobacteria (~0.02%). Among the genera, Lactococcus was found to be the most dominant bacterium. The predominance of Lactococcus in neem gum is probably due to its acidic nature, which provides a suitable microenvironment for its proliferation. In addition, Lactococcus and beneficial microorganisms such as Pseudomonas, Burkholderia, Pantoea, Klebsiella, and Methylobacterium were also present in the gum. This study highlights the fact that neem gum can be exploited as a unique source of microorganisms for biotechnological and agricultural applications.
Firearms Detection to Monitor Activities of a Person Using Deep Learning Method (YOLOv4) for Smart Surveillance System
Authors: Kumar Mr. P. Mahesh
Published: May 2023

Abstract: This paper proposes a weapon detection system that utilizes the YOLOv4 algorithm to detect weapons in real-time through three features: web cam detection, IPaddress detection, and video file weapon detection. The proposed system is designed to assist law enforcement agencies andsecurity personnel in detecting andpreventing potential violent incidents inpublic places such as airports, schools, and other high-risk areas. The web cam detectionfeature of the system allows for real-timemonitoring of public places through webcams. The system processes video streams from the webcams and automaticallydetects any weapon that appears in the frame. The IP address detection feature enables the system to detect weapons in live video streams from remote cameras with assigned IP addresses. This feature expands the system's reach beyond physical locations, providing an additional layer of security. Thevideo file weapon detection feature allows the system to analyze pre-recorded video files to detect weapons that were missed during live monitoring. This feature is particularly useful for forensic analysis after an incident has occurred. Overall, this proposed weapon detection system using YOLOv4 algorithm and three features is an effective solution for real-time weapon detection in public places, increasing the security and safety of the general public.
Production of Biodiesel from Algae
Authors: Chandane Pratik
Published: May 2023

Abstract: Microalgae provide a large amount potential for the utilization, which contains the large amount of biodiesel, but the method is not very advance. In the this idea the knowledge we want is very less. In this paper we are going to look at the potential of microalgae to take the dynamic steps to improve our study about the microalgae to understand the patterns of changes. In doing this we required the combination of biology and engineering. In this review, We present an overview of potential algal biofuel pipelines and highlight current work to optimize algal biomass production and the molecular fuel content of algal cells. Using hexane as a solvent and simultaneous extraction and transesterification, the highest possible yield of biodiesel was achieved. To determine the potential of microalgae to produce biodiesel, Algal biomass, algae oil, and algae biodiesel were all thoroughly characterized.