bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical characteristics of children and guardians possessing CBP-positive Streptococcus mutans strains: a cross-sectional study
Authors: Otsugu Masatoshi , Mikasa Yusuke , Kitamura Takahiro , Suehiro Yuto , Matayoshi Saaya , Nomura Ryota , Nakano Kazuhiko
Published: October 2022

Streptococcus mutans is a major etiological agent for dental caries. We previously demonstrated that S. mutans strains expressing collagen-binding proteins (CBPs) were related to the pathogenesis of systemic diseases. However, their acquisition and colonization remain unknown. Here, we investigated the detection rates of CBP-positive S. mutans strains in children and their guardians to clarify the background for the acquisition and colonization in children. Saliva samples were collected from children and their mothers, and detection of S. mutans and collagen-binding genes (cnm, cbm) was performed by PCR after DNA extraction. The oral status of each child was examined, and their mothers were asked to complete a questionnaire. The isolation rate of Cnm-positive S. mutans was significantly higher in mothers than in children. Notably, the possession rates of CBP-positive strains in children were significantly higher in children whose mothers had CBP-positive strains than in children whose mothers did not have these strains. Furthermore, children with CBP-positive strains had a significantly shorter breastfeeding period than children without these strains. The present results suggest that nutritional feeding habits in infancy are one of the factors involved in the acquisition and colonization of CBP-positive S. mutans strains.
Investigation of mixing viscoplastic fluid with a modified anchor impeller inside a cylindrical stirred vessel using Casson–Papanastasiou model
Authors: Benhanifia Kada , Redouane Fares , Lakhdar Rahmani , Brahim Mebarki , Al-Farhany Khaled , Jamshed Wasim , Eid Mohamed R. , El Din Sayed M. , Raizah Zehba
Published: October 2022

In process engineering as chemical and biotechnological industry, agitated vessels are commonly used for various applications; mechanical agitation and mixing are performed to enhance heat transfer and improve specific Physico-chemical characteristics inside a heated tank. The research subject of this work is a numerical investigation of the thermo-hydrodynamic behavior of viscoplastic fluid (Casson–Papanastasiou model) in a stirred tank, with introducing a new anchor impeller design by conducting some modifications to the standard anchor impeller shape. Four geometry cases have been presented for achieving the mixing process inside the stirred vessel, CAI; classical anchor impeller, AI1; anchor impeller with added horizontal arm blade, AI2 and AI3 anchor impeller with two and three added arm blades, respectively. The investigation is focused on the effect of inertia and plasticity on the thermo-hydrodynamic behavior (flow pattern, power consumption, and heat transfer) by varying the Reynolds number (Re = 1, 10, 100, 200), Bingham number (Bn = 1, 10, 50), in addition to the effect of geometry design in the overall stirred system parameters. The findings revealed an excellent enhancement of flow pattern and heat transfer in the stirred system relatively to the increase of inertia values. Also, an energy reduction has been remarked and the effect of anchor impeller shape. AI3 geometry design significantly improves the flow pattern and enhances heat transfer by an increased rate of 10.46% over the other cases.
Reduced renal elimination of larger molecules is a strong predictor for mortality
Authors: Herou Erik , Grubb Anders , Dardashti Alain , Nozohoor Shahab , Zindovic Igor , Ederoth Per , Bjursten Henrik
Published: October 2022

Renal dysfunction is a major risk factor for premature death and has been studied extensively. A new renal syndrome, shrunken pore syndrome (SPS), confers higher mortality in all studied populations. SPS is a condition in which cystatin C-based estimation of glomerular filtration rate (eGFRcystatin C) is ≥ 60% than creatinine-based estimation of glomerular filtration rate (eGFRcreatinine). We aimed to study the impact of SPS on mortality in a cohort of patients with follow up of up to 10 years. This was a retrospective single centre cohort study. We enrolled 3993 consecutive patients undergoing elective cardiac surgery. Outcome was evaluated using Kaplan Meier analysis and multivariable Cox regression. 1-, 5- and 10-year survival for patients with SPS was 90%, 59% and 45%, and without SPS 98%, 88% and 80% (p < 0.001). SPS was found to be an independent predictor for mortality with an HR of 1.96 (95% CI 1.63–2.36). SPS negatively affected survival regardless of pre-operative renal function. SPS is an independent predictor for mortality after elective cardiac surgery, equal to or greater than risk factors such as diabetes, impaired left ventricular function or renal dysfunction. SPS affected mortality even in patients with normal eGFR.

Clinical registration number: ClinicalTrials.gov, ID NCT04141072.
Determination of antimicrobial agents and their transformation products in an agricultural water-soil system modified with manure
Authors: Stando Klaudia , Korzeniewska Ewa , Felis Ewa , Harnisz Monika , Buta-Hubeny Martyna , Bajkacz Sylwia
Published: October 2022

Manure fertilization is the primary source of veterinary antimicrobials in the water-soil system. The research gap is the fate of antimicrobials after their release into the environment. This study aimed to provide a detailed and multi-faceted examination of fertilized cultivated fields using two types of manure (poultry and bovine) enriched with selected antimicrobials. The research focused on assessing the mobility and stability of antimicrobials in the water-soil system. Additionally, transformation products of antimicrobials in the environment were identified. The extraction (solid-phase extraction and/or solid–liquid extraction) and LC–MS/MS analysis procedures were developed to determine 14 antimicrobials in the soil and pore water samples. Ten out of fourteen antimicrobials were detected in manure-amended soil and pore water samples. The highest concentration in the soil was 109.1 ng g−1(doxycycline), while in pore water, it was 186.6 ng L−1(ciprofloxacin). Sixteen transformation products of antimicrobials were identified in the soil and soil-related pore water. The same transformation products were detected in both soil and soil pore water extracts, with significantly higher signal intensities observed in soil extracts than in water. Transformation products were formed in oxidation, carbonylation, and ring-opening reactions.
Heterogeneous graph neural network for lncRNA-disease association prediction
Authors: Shi Hong , Zhang Xiaomeng , Tang Lin , Liu Lin
Published: October 2022

Identifying lncRNA-disease associations is conducive to the diagnosis, treatment and prevention of diseases. Due to the expensive and time-consuming methods verified by biological experiments, prediction methods based on computational models have gradually become an important means of lncRNA-disease associations discovery. However, existing methods still have challenges to make full use of network topology information to identify potential associations between lncRNA and disease in multi-source data. In this study, we propose a novel method called HGNNLDA for lncRNA-disease association prediction. First, HGNNLDA constructs a heterogeneous network composed of lncRNA similarity network, lncRNA-disease association network and lncRNA-miRNA association network; Then, on this heterogeneous network, various types of strong correlation neighbors with fixed size are sampled for each node by restart random walk; Next, the embedding information of lncRNA and disease in each lncRNA-disease association pair is obtained by the method of type-based neighbor aggregation and all types combination though heterogeneous graph neural network, in which attention mechanism is introduced considering that different types of neighbors will make different contributions to the prediction of lncRNA-disease association. As a result, the area under the receiver operating characteristic curve (AUC) and the area under the precision-recall curve (AUPR) under fivefold cross-validation (5FCV) are 0.9786 and 0.8891, respectively. Compared with five state-of-art prediction models, HGNNLDA has better prediction performance. In addition, in two types of case studies, it is further verified that our method can effectively predict the potential lncRNA-disease associations, and have ability to predict new diseases without any known lncRNAs.
Usefulness of hand grip strength to estimate other physical fitness parameters in older adults
Authors: Kim Su Hyun , Kim Taegyu , Park Jong-Chul , Kim Young Hoon
Published: October 2022

This study aimed to reveal the status of physical fitness (PF) levels and determine whether hand grip strength (HGS) could be used to estimate other PF parameters in older adults from large population data. A total of 46,269 participants aged ≥ 65 years who participated in the 2019 National Fitness Award Project in South Korea were included in the analysis. Of the participants, 6.8% had the highest level of overall physical fitness, while 48.9% had the lowest level. The proportion of overall PF levels differed significantly according to age groups. Significant associations between HGS and other PF parameters (30-s chair stand test, 2-min or 6-min walk test, sit-and-reach test, 3-m backwards walk test, and Figure-of-8 walk test) were noted and the group with low HGS (< 28 kg for men and < 18 kg for women) had significantly higher odds of having the lowest level of overall PF (odds ratio: 5.232 in men and 6.351 in women), after adjusting for age and body mass index. HGS could estimate muscular strength and endurance, aerobic fitness, flexibility, balance skills, and coordination skills, as well as overall PF level in older adults, and could be used as a substitute test for their PF level in limited situations.
Evaluation of the microperimetry in eyes with cuticular drusen
Authors: Nam Seung Wan , Lee Jung Hwa , Byun Zeeyoon , Ham Don-Il , Kong Mingui
Published: October 2022

Retinal sensitivity may vary by subtypes of cuticular drusen. This retrospective study included 52 eyes of 32 patients with cuticular drusen. All the patients underwent assessment of best-corrected visual acuity (BCVA), spectral-domain optical coherence tomography (SD-OCT), color fundus photography, fluorescein angiography, fundus autofluorescence, and microperimetry. The area occupied by drusen was counted using microperimetry. The cuticular drusen subtype was classified into 3 groups based on the SD-OCT findings. Age, BCVA, pattern standard deviation, area occupied by drusen, pupil size, and the false-positive rate were not significantly different (p > 0.05) according to the cuticular drusen type. The mean retinal sensitivity (MRS) (p = 0.063) and mean deviation (MD) (p = 0.098) showed marginally significant differences among the groups. In the subgroup analyses, type 1 and type 3 cuticular drusen showed significant differences in the MD (− 1.8 ± 2.1 vs − 5.1 ± 5.3; p = 0.011) and MRS (25.1 ± 2.2 vs 21.3 ± 5.7; p = 0.016) without differences in age, BCVA, or the area occupied by drusen (p > 0.05). The results indicate that depending on the subtypes of cuticular drusen type, the deterioration of retinal sensitivity is more likely to occur than decreased vision.
Effect of a light-darkness cycle on the body weight gain of preterm infants admitted to the neonatal intensive care unit
Authors: Sánchez-Sánchez Manuel , García Teodoro L. , Heredia Donají , Reséndiz Isaac , Cruz Lorena , Santiago Jacqueline , Rojas-Granados Adelina , Ubaldo-Reyes Laura , Pérez-Campos-Mayoral Laura , Pérez-Campos Eduardo , Vásquez Gervacio S. , Moguel Juan M. , Zarate Romeo , García Oscar , Sánchez Luisa , Torres Fernando , Paz Alberto , Elizarraras-Rivas Jesús , Hernández-Huerta María T. , Angeles-Castellanos Manuel
Published: October 2022

The Continuous bright light conditions to which premature infants are subjected while hospitalized in Neonatal Intensive Care Units (NICU) can have deleterious effects in terms of growth and development. This study evaluates the benefits of a light/darkness cycle (LDC) in weight and early hospital discharge from the NICU. Subjects were recruited from three participating institutions in Mexico. Eligible patients (n = 294) were premature infants who were hospitalized in the low-risk and high-risk neonatal units classified as stable. The subjects randomized to the experimental group (n = 150) were allocated to LDC conditions are as follows: light from 07:00 to 19:00 and darkness (25 lx) from 19:00 to 07:00. The control group (n = 144) was kept under normal room light conditions (CBL) 24 h a day. Main outcome was weight gain and the effect of reducing the intensity of nocturnal light in development of premature infants. Infants to the LDC gained weight earlier, compared with those randomized to CBL, and had a significant reduction in length of hospital stay. These results highlight those premature infants subjected to a LDC exhibit improvements in physiological development, favoring earlier weight gain and consequently a decrease in hospital stays. ClinicalTrials.gov; 02/09/2020 ID: NCT05230706.
Hepatic urea, creatinine and uric acid metabolism in dairy cows with divergent milk urea concentrations
Authors: Prahl Marie C. , Müller Carolin B. M. , Albrecht Dirk , Koch Franziska , Wimmers Klaus , Kuhla Björn
Published: October 2022

Milk urea concentration is an indicator for dietary nitrogen (N)-supply and urinary N-excretion. Dairy cows with high (HMU) compared to low milk urea (LMU) concentration have greater plasma urea, creatinine and uric acid concentrations, but if the liver metabolism accounts for these differences is unknown. Eighteen HMU and 18 LMU cows were fed a diet with a low (LP) or normal (NP) crude protein concentration. A N balance study was performed and a 13C-urea bolus was administered to measure urea pool size. Liver samples were analyzed by 2D-gel-based proteomics and RT-qPCR. Although HMU cows had a greater urea pool, plasma urea, uric acid, and hippuric acid concentrations, these differences were not associated with altered expressions of genes related to urea cycling or N-metabolism. Instead, HMU cows had higher oxidative stress levels. Conclusively, other factors than hepatic urea metabolism account for milk urea concentrations. Despite higher plasma urea concentrations and argininosuccinate synthase 1 protein expression on the LP diet, urea cycle mRNA expressions were not affected, indicating that its activity is not controlled at transcriptional level. Feeding the LP diet resulted in increased expressions of enzymes catabolizing fatty acids, but the reason remains to be investigated in future studies.
Embedding cognitive framework with self-attention for interpretable knowledge tracing
Authors: Pu Yanjun , Wu Wenjun , Peng Tianhao , Liu Fang , Liang Yu , Yu Xin , Chen Ruibo , Feng Pu
Published: October 2022

Recently, deep neural network-based cognitive models such as deep knowledge tracing have been introduced into the field of learning analytics and educational data mining. Despite an accurate predictive performance of such models, it is challenging to interpret their behaviors and obtain an intuitive insight into latent student learning status. To address these challenges, this paper proposes a new learner modeling framework named the EAKT, which embeds a structured cognitive model into a transformer. In this way, the EAKT not only can achieve an excellent prediction result of learning outcome but also can depict students’ knowledge state on a multi-dimensional knowledge component(KC) level. By performing the fine-grained analysis of the student learning process, the proposed framework provides better explanatory learner models for designing and implementing intelligent tutoring systems. The proposed EAKT is verified by experiments. The performance experiments show that the EAKT can better predict the future performance of student learning(more than 2.6% higher than the baseline method on two of three real-world datasets). The interpretability experiments demonstrate that the student knowledge state obtained by EAKT is closer to ground truth than other models, which means EAKT can more accurately trace changes in the students’ knowledge state.
Biofunctional soy-based sourdough for improved rheological properties during storage
Authors: Teleky Bernadette-Emőke , Martău Gheorghe Adrian , Ranga Floricuța , Pop Ioana Delia , Vodnar Dan Cristian
Published: October 2022

Frozen dough storage, along with its thawing process, negatively affects the quality of the final product. Thus, fermentation with selected cultures and the enrichment of wheat-based dough using a specific soy powder could optimize the viscoelastic quality of frozen dough and increase its nutritional characteristics. Based on these aspects, the present study’s objective was to examine the effects of soy powder addition to wheat flour with single cultures of Fructilactobacillus florum DSM 22689 or Saccharomyces cerevisiae and coculture with these two microorganisms for 72 h of fermentation. Additionally, the fermentation process was monitored, and viscoelastic behavior and physical–chemical analyses of the fermented sourdough before and after frozen storage were assessed, as soy protein has been proposed to hinder water migration throughout frozen storage. As observed, soy powder, an essential functional ingredient, had a favorable impact on the water-starch-gluten system, and enhanced the viscoelastic behavior before and after 4 weeks of frozen storage.
Randomized, double-blinded, controlled clinical trial of the effect of captopril, telmisartan and their combination on systemic inflammation of patients on hemodialysis
Authors: Ordaz-Medina Susan M. , Cueto-Manzano Alfonso M. , González-Plascencia Juana , Montañez-Fernández José L. , Ordaz-Medina Elias J. , Martín-del-Campo Fabiola , Cueto-Ramírez Alfonso M. , Martínez-Martínez Petra , Cortés-Sanabria Laura , Rojas-Campos Enrique , Trujillo-Hernández Benjamín
Published: October 2022

To evaluate individual and combined effect of captopril and telmisartan on systemic inflammation markers of hemodialysis (HD) patients. Randomized, double-blinded, controlled clinical trial. Patients on HD at least 2 months, with arteriovenous fistula, were randomly allocated to groups: (1) captopril/placebo (N 13); (2) telmisartan/placebo (N 13); (3) captopril + telmisartan (N 12); or (4) placebo/placebo (N 12). During 3 months, patients received oral drugs as follows: captopril 50 mg/day, telmisartan 80 mg/day or placebo. Patients excluded if they had conditions or were on drugs potentially influencing on inflammation. Clinical and biochemical evaluations were performed monthly. Serum tumor necrosis factor alpha (TNFα), interleukin 6 (IL-6), and C-reactive protein (CRP) were measured at 0, 1 and 3 months. Baseline, demographic, clinical and biochemical variables were comparable between groups. Baseline versus final inflammatory markers were: captopril/placebo TNFα, 2.47 (0.1–4.5) versus 1.73 (0.3–3.8) pg/ml; IL-6, 17.03 (7.2–23) versus 7.90 (0.7–19) pg/ml; CRP, 4.21 (1.6–18) versus 5.9 (3.0–28) mg/l; telmisartan/placebo TNFα, 3.03 (2.3–4.6) versus 1.70 (1.2–2.0) pg/ml; IL-6, 14.10 (5.5–23) versus 9.85 (6.2–13) pg/ml; CRP, 5.74 (2.1–13) versus 10.60 (1.5–27) mg/l; captopril + telmisartan TNFα, 1.43 (0.7–5.4) versus 0.40 (0.1–2.1) pg/ml; IL-6, 10.05 (4.9–23) versus 4.00 (0.7–7.7) pg/ml (p < 0.05); CRP, 3.26 (0.7–12) versus 2.83 (0.6–6.5) mg/l; placebo/placebo TNFα, 3.13 (1.6–5.6) versus 1.64 (1.6–2.3) pg/ml; IL-6, 8.12 (5.4–16) versus 7.60 (2.4–15) pg/ml; CRP, 5.23 (1.9–16) versus 3.13 (1.5–18) mg/l. Monotherapy with captopril or telmisartan display a trend, but their combined treatment significantly decreased serum levels of IL-6. No remarkable changes on TNFα and CRP were observed.
The additive effect of genetic and metabolic factors in the pathogenesis of nonalcoholic fatty liver disease
Authors: Seko Yuya , Yamaguchi Kanji , Yano Kota , Takahashi Yusuke , Takeuchi Kento , Kataoka Seita , Moriguchi Michihisa , Itoh Yoshito
Published: October 2022

Both genetic and metabolic factors influence the pathology of nonalcoholic fatty liver disease (NAFLD). The aim of this retrospective study was to evaluate the impact of these factors at each stage of disease. We analysed the impact of obesity, diabetes mellitus and genetic risk factors (alleles ofPNPLA3orHSD17B13) on nonalcoholic steatohepatitis (NASH), significant fibrosis (stage ≥ 2) and advanced fibrosis (stage ≥ 3) in 346 patients. Genetic high risk was defined as having at least 2 risk alleles. The median age was 59 years, median body mass index was 27.1 kg/m2, and 46.8% had diabetes mellitus. Obesity was a risk factor for NASH, significant fibrosis, and advanced fibrosis. Diabetes mellitus increased the risk of NASH. Genetic risk increased the risk of significant and advanced fibrosis. Odds ratios for NASH, significant fibrosis and advanced fibrosis increased with the number of genetic and metabolic risk factors. The patients with both metabolic and genetic risks had an odds ratio of 12.30 for NASH, 5.50 for significant fibrosis, and 6.25 for advanced fibrosis. Factors strongly impact on the pathology of NAFLD differed according to the fibrosis stages. Synergistic effects were observed between genetic and metabolic factors at all stages.
A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation
Authors: Sadat Zahra , Farrokhi-Hajiabad Farzaneh , Lalebeigi Farnaz , Naderi Nooshin , Ghafori Gorab Mostafa , Ahangari Cohan Reza , Eivazzadeh-Keihan Reza , Maleki Ali
Published: October 2022

Applications of carbon-based nanocomposites in accelerating of wound healing process.
A dual-adjuvant neoantigen nanovaccine loaded with imiquimod and magnesium enhances anti-tumor immune responses of melanoma
Authors: Chen Xinjie , Cen Lanqi , Liu Qin , Chu Yanhong , Feng Xiaoyu , Ke Yaohua , Zhang Zhe , Dai Hengheng , Huang Shuling , Liu Baorui , Qian Xiaoping
Published: October 2022

A dual-adjuvant neoantigen nanoparticle loaded with imiquimod and magnesium (R837-Pep@HM NP) can enhance the anti-tumor immune response. The dendritic cells activated and presented neoantigens, which in turn activated T cells and killed tumor cells.
Ru/Rh catalyzed selective hydrogenation of CO2 to formic acid: a first principles microkinetics analysis
Authors: Ghoshal Sourav , Roy Prodyut , Pramanik Anup , Sarkar Pranab
Published: October 2022

Unsupported and oxygen deficient TiO2 surface supported small Rux/Rhx nanoclusters can efficiently and selectively convert CO2 into formic acid.
Covalent surface modification of bifunctional two-dimensional metal carbide MXenes as sulfur hosts for sodium–sulfur batteries
Authors: Li Na , Zhan Yulu , Wu Haishun , Fan Jun , Jia Jianfeng
Published: October 2022

We find that surface terminations of MXenes significantly affect their electrochemical performance as sulfur hosts for RT Na–S batteries. Ti2CO2, Ti2CS2, and Ti2CN2 are demonstrated to be promising bifunctional sulfur hosts for Na–S batteries.
Unusual DBU-catalyzed decarboxylative formation of allylic thioethers from vinyl cyclic carbonates and thiols
Authors: Ni Jixiang , Lanzi Matteo , Kleij Arjan W.
Published: October 2022

Vinyl cyclic carbonates undergo anexo-cyclic attack by thiol nucleophiles under DBU catalysis to form allylic thioether products in moderate to good yields through a decarboxylative process under attractive process conditions.
Synthesis and biological evaluation of novel sinomenine derivatives as anti-inflammatory and analgesic agent
Authors: Gao Feng , Dai Ziqi , Zhang Tong , Gu Yuhao , Cai Desheng , Lu Mingjun , Zhang Zijie , Zeng Qi , Shang Bingxian , Xu Bing , Lei Haimin
Published: October 2022

A series of novel sinomenine derivatives were designed and synthesized. Among them, compound 17 showed strong anti-inflammatory and analgesic activities.
Revisiting the Mukaiyama-type epoxidation for the conversion of styrene into styrene carbonate in the presence of O2 and CO2
Authors: Balas Matthieu , Mayoufi Asma , Villanneau Richard , Launay Franck
Published: October 2022

Alkene epoxidation using the Mukaiyama process involving O2 and a sacrificial aldehyde, as the first step of the global alkene oxidative carboxylation, does not necessarily require a metal catalyst.
Norbornene-tetrazine ligation chemistry for controlling RNA-guided CRISPR systems
Authors: Qi Qianqian , Zhang Yutong , Xiong Wei , Liu Xingyu , Cui Shuangyu , Ye Xiaofang , Zhang Kaisong , Tian Tian , Xiang Zhou
Published: October 2022

Here, norbornene-tetrazine ligation chemistry is harnessed to control RNA-guided CRISPR systems in vitro and in human cells.
Geometry-controlled instabilities for soft–soft adhesive interfaces
Authors: Thomas Elayne M. , Fu Hongbo , Hayward Ryan C. , Crosby Alfred J.
Published: October 2022

Geometry controls the delamination mechanism of soft–soft adhesive interfaces, and is predicted through an additive compliance model.
Correction: Development of a transferable coarse-grained model of polydimethylsiloxane
Authors: Cambiaso Sonia , Rasera Fabio , Rossi Giulia , Bochicchio Davide
Published: October 2022

Correction for ‘Development of a transferable coarse-grained model of polydimethylsiloxane’ by Sonia Cambiaso et al., Soft Matter, 2022, https://doi.org/10.1039/d2sm00939k.
High-performance trimethylamine gas sensors based on defect-engineering MOF-derived ZnO nanoclusters with tunable surface oxygen vacancies
Authors: Yu Shaoyuan , Dong Jingshi , Wang He , Li Sirui , Zhu Hang , Yang Tianye
Published: October 2022

DE MOF-derived ZnO nanoclusters with tunable surface oxygen vacancies are synthesized. Comprehensive characterization techniques and DFT calculations indicate that surface oxygen vacancies effectively promote the TMA sensing performance.
Two-dimensional magnetic bimetallic organic framework nanosheets for highly efficient enrichment of phosphopeptides
Authors: Yan Shuang , Luo Bin , Cheng Jia , Yu Lingzhu , Lan Fang , Wu Yao
Published: October 2022

Fe3O4@Zr–Ti BPDC nanosheets were flexibly developed for effective and selective enrichment of phosphopeptides by combining the dual affinities of Zr–O and Ti–O clusters.
Correction: PCL NGCs integrated with urolithin-A-loaded hydrogels for nerve regeneration
Authors: Jin Xue-Han , Fang Jia-Qi , Wang Jian-Guang , Xu Bo , Wang Xu , Liu Shu-Hao , Chen Feng , Liu Jun-Jian
Published: October 2022

Correction for ‘PCL NGCs integrated with urolithin-A-loaded hydrogels for nerve regeneration’ by Xue-Han Jin et al., J. Mater. Chem. B, 2022, https://doi.org/10.1039/D2TB01624A.
A novel high efficiency emission-tunable solid solution luminescent material with non-concentration-quenching and excellent thermal stability
Authors: Kang Runtian , Wang Yuhua
Published: October 2022

A series of phosphors were obtained from a solid solution of Eu2+ in SrAl2Si3O4N4. This series of phosphors shows non-concentration quenching and excellent thermal stability.
Impact of crystal growth diversity on magneto-photoluminescence and circular dichroism in chiral lead halide perovskites
Authors: Pan Ruiheng , Hu Jiaji , Tao Sheng , Kan Lixuan , Yu Haomiao , Wang Kai
Published: October 2022

By tuning weight percentages rationally for precursor solutions, we found that large magneto-PL (−13.2%) with strong tunability via polarized photoexcitation is highly decided by crystallographic orientations for chiral perovskites.
A Scoping Review and Tutorial for Developing Standardized and Transparent Protocols for Flexible Endoscopic Evaluation of Swallowing
Authors: Curtis James A.
Published: October 2022

Purpose:

Standardization and transparency are essential components for enhancing an assessment's objectivity and reproducibility. Currently, it is up to the individual clinician to develop a standardized protocol that works for their clinical setting and patient populations. Therefore, the primary aim of this clinical focus article is to present a scoping review of research that can aid clinicians as they develop standardized and transparent protocols for flexible endoscopic evaluation of swallowing (FEES).

Method:

A brief background is provided characterizing the diagnostic advantages and limitations of FEES and describing why increased standardization and transparency for the performance of FEES is needed. Research examining examination preparation parameters (topical nasal anesthetics, vasoconstrictors, lubrication, anxiety) and swallowing protocols (swallowing instructions, bolus volumes, bolus consistencies, number of trials, colorants) is then explored. Last, step-by-step instructions and examples on developing a protocol are outlined.

Conclusions:

FEES is a gold standard approach for examining functional swallowing outcomes in people with known or suspected dysphagia. Standardizing and transparentizing the performance of FEES, the swallowing protocol, and the rating methods are critical for successful use of FEES in clinical and research practices.
Comparison of machine learning algorithms to predict optimal dwelling time for package tour
Authors: Wahyutama Aria Bisma , Hwang Mintae
Published: October 2022

This paper shows the comparison between several well‐known classification algorithms in Machine Learning with the purpose of finding the most suitable algorithm to predict the dwelling time, that is, how long a certain tourist should stay in a particular tourist spot. This dwelling time prediction can be adopted by tour and travel agents to provide optimal scheduling for their package tours. The algorithm in question is strictly for classification because in this case, the dwelling time does not require a very specific number of minutes; thus, the time can be classified and restricted into several time frames. The origin and features of the dataset are described in this paper as well as the comparison methodology to show the procedure of how the comparison was made. Lastly, the performance results will be used to determine which algorithm to use for this specific case and it will be shown in a form of a graph.
Individuelle somatische Klassifikation von Neugeborenen auf der
Grundlage von Körperhöhe und Körpergewicht der Mutter
(Ergebnisse einer Validierungsstudie)
Authors: Voigt Manfred , Nikischin Werner , Hentschel Roland , Strauss Alexander , Kunze Mirjam , Ensenauer Regina , Wittwer-Backofen Ursula , Hagenah Hans-Peter , Olbertz Dirk , Rochow Niels
Published: October 2022

Einleitung Das Geburtsgewicht ist u. a. durch die
mütterliche Größe beeinflusst. Die SGA-Rate Neugeborener
relativ kleiner und leichter Mütter
(<158 cm,<53 kg) und die LGA-Rate relativ
großer und schwerer Mütter
(+> 177 cm,>79 kg) werden
überschätzt. Die LGA-Rate Neugeborener relativ kleiner und
leichter Mütter und die SGA-Rate relativ großer und schwerer
Mütter wird unterschätzt. Individualisierte
Geburtsgewichtsperzentilen (IGGP) basierend auf 18 Müttergruppen (6
Körperhöhengruppen mit jeweils 3 Gewichtsgruppen), Geschlecht
und Schwangerschaftswochen wurden publiziert. Das Ziel dieser Studie ist die
Validierung der IGGP durch Evaluierung der SGA-, AGA- und LGA-Raten an einem
unabhängigen Perinataldatensatz.

Methoden Die Validierungsstudie vergleicht IGGP (1995 bis 2000,
n=2,2 Mio Einlingsschwangerschaften) mit Perzentilwerten aus zwei
gesamtdeutschen Kohorten (i: 1995 bis 2000; n=2,3 Mio und ii: 2007 bis
2011, n=3,2 Mio) anhand von Neugeborenen der niedersächsischen
Perinatalerhebung (n=0,56 Mio Einlingsschwangerschaften von 2001 bis
2009). SGA-, AGA- und LGA-Raten werden berechnet mit dem Statistikprogramm
R.

Ergebnisse Die Perzentilwerte der Gesamtpopulation 1995–2000 bzw.
2007–2011 ergaben SGA-Raten bei relativ kleinen und leichten
Müttern von 21,1 bis 21,6% und LGA-Raten von 2,0 bis
3,1%. Bei relativ großen und schweren Müttern waren die
SGA-Raten von 3,3 bis 3,5% und die LGA-Raten von 26,6 bis 27,1%.
Die IGGP erreichten SGA-Raten von 9,0% und LGA-Raten von 11,4 bis
11,6% bei relativ kleinen und leichten Müttern sowie SGA- und
LGA-Raten von annähernd 10% bei relativ großen und
schweren Müttern.

Diskussion IGGP berücksichtigen das Wachstumspotential von Feten
entsprechend der mütterlichen Größe und erreichen die
erwarteten SGA- und LGA-Raten von 10%. Die Berücksichtigung des
individuellen Wachstumspotential vermeidet ein Unter- und
Überschätzen von SGA- und LGA-Raten. IT-unterstützte
Analysen des Geburtsgewichtes mit IGGP vereinfachen die Anwendung.
Evidenzbasierte Lokaltherapie chronischer Wunden
Authors: Dissemond Joachim , Lobmann Ralf
Published: October 2022

Chronische Wunden sind zumeist durch Grunderkrankungen wie Diabetes mellitus oder Gefäßerkrankungen bedingt und stellen eine große Problematik in der zunehmend alternden Gesellschaft dar. Die inadäquate Behandlung geht oftmals mit protrahierter Wundheilung, erhöhten Risiken für Komplikationen, eingeschränkter Lebensqualität der Betroffenen und langwierigen Therapien mit hohen Behandlungskosten einher.

Die erfolgreiche Therapie setzt eine frühzeitige adäquate Diagnostik, Kausaltherapie sowie Wundbehandlung möglichst auf Basis evidenzbasierter Medizin voraus. Diese Behandlung sollte dann in qualifizierten Versorgungsstrukturen anhand konkreter Behandlungspfade erfolgen. Somit können in der täglichen Praxis eine verbesserte Wundheilung mit gesteigerter Lebensqualität der Patienten sowie ein medizinökonomischer Vorteil erreicht werden.

In diesem Übersichtsartikel wird die evidenzbasierte Lokaltherapie chronischer Wunden mit Schwerpunkt auf Wundverbänden mit TLC-Sucrose-Octasulfat-Beschichtung dargestellt. Leitlinien und Behandlungspfade sowie pharmaökonomische Aspekte werden dabei berücksichtigt.
How Important are Psychological Measures to Determine Readiness to Return to Sports after Reconstruction of the Anterior Cruciate Ligament? An Online Survey Study
Authors: Newmarch Tate , Betsch Marcel , Michalik Roman , Dwyer Tim , Whelan Daniel , Chahal Jaskarndip , Theodoropoulos John
Published: October 2022

Background Recent studies have suggested that psychological factors are important components of a successful return to sports (RTS) after anterior cruciate ligament reconstruction (ACLR). The purpose of this study was to survey physicians with respect to their criteria used to determine readiness to RTS after ACLR and to understand the significance of psychological factors on RTS.

Methods A survey was designed to understand the practices of clinicians managing rehabilitation after ACLR, consisting of 25 questions divided into 3 different sections, including one section about psychological scores and factors affecting RTS. The survey was delivered to three North American organizations for orthopedic sports medicine.

Results The total number of respondents was 113. Of the respondents, 95% considered psychological tests at least “somewhat important” (33% “important”, 23% selected “very important”). Routine use of psychological tests in practice was only reported by 35% of respondents. The ACL-Return to Sport after Injury Scale was the most frequently used psychological test (23%). Fear of reinjury was considered the most common patient-cited psychological factor affecting RTS. Psychological factors ranked 8th out of 9 outcomes measures in determining readiness to RTS.

Conclusion This study demonstrates a discrepancy between the importance of psychological tests and the frequency of use in practice. Additional education on this topic, web-based applications, and a multidisciplinary approach may increase the usage of psychological tests to determine RTS after ACLR.
Study of PD-L1 Expression with Association of Pathological Factors and Molecular Subtypes in Breast Carcinoma
Authors: Gupta Abhishek , Chandra Smita , Chauhan Neena , Arora Anshika
Published: October 2022

Background Programmed death ligand 1 (PD-L1), expressed on cancer cells, shows varied results in the prognosis of breast cancer. This study was conducted to study the expression of PD-L1 in breast carcinoma and to correlate it with pathological, molecular classification and prognostic factors.

Materials and Methods PD-L1 expression was correlated with tumor size, histopathological grade, necrosis, lymphovascular, perineurial invasion, lymph node metastasis, molecular classification, and survival in breast carcinoma cases.

Results Fifty cases were included which showed statistically significant difference of PD-L1 with mean age, tumor size, histopathological grade, lymphovascular emboli, and lymph node metastasis (p < 0.05). Estrogen receptor was strongly positive in 46%, progesterone receptor in 42%, and PD-L1 in 6% of cases. No statistically significant difference between pathological tumor–node–metastasis (TNM) staging and PD-L1 expression (p = 0.354) was observed. Receptor operating characteristic curve analysis showed that at the cutoff of PD-L1 greater than 120, specificity was 56.1%, sensitivity 66.7%, negative predictive value 88.5%, and positive predictive value 25% for predicting living status.

Conclusion PD-L1 is associated with poor prognostic factors including tumor size, histopathological grade, lymphovascular emboli, and lymph node metastasis in breast carcinoma. However, no significant association was observed between PD-L1 and pathological TNM stage or molecular subtypes of breast carcinoma. It is suggested that immunohistochemical reporting of PD-L1 should be standardized so that it is reproducible and reliable for the evaluation of breast carcinoma. Further, larger studies with extended follow-ups are recommended so that the exact role of PD-L1 as a prognostic marker in breast carcinoma could be ascertained.
Ceftriaxone Resistant Salmonella enterica Serovar Kentucky as a Cause of Bacteremia and Gastroenteritis: A Case Report
Authors: Neelambike Sumana M. , Chitharagi Vidyavathi , Rao Morubagal Raghavendra , Badveti Satyasai
Published: October 2022

Salmonella enterica serovar Kentucky is an emerging human pathogen in developed countries and also a concern for public health in developing countries. Although genus Salmonella is usually susceptible to many antimicrobial agents, a recent increase in resistance has become a cause for concern. A case of ceftriaxone resistant Salmonella enterica serovar Kentucky causing bacteremia and acute gastroenteritis is reported in this paper. The Salmonella Kentucky isolate in this case was resistant to most classes of antibiotics. This is the first case report of Salmonella enterica serovar Kentucky resistant to ceftriaxone. Multidrug resistant patterns of Salmonella Kentucky are observed globally. Awareness of various nontyphoid Salmonella causing human infections is of utmost importance, because delayed identification, serotyping, and susceptibility testing may delay the administration of antibiotics leading to worsening outcomes.
Twin Malignancy of Acute Myeloid Leukemia and Multiple Myeloma in a Chemotherapy-Naïve Patient: A Rare Occurrence
Authors: Jamal Iffat , Shuchismita Shuchismita , Choudhary Vijayanand
Published: October 2022

Synchronous diagnosis of acute myeloid leukemia (AML) and multiple myeloma in chemotherapy-naïve patients is a rare event and poses a serious therapeutic challenge as it imparts a poor prognosis. We report a case of concurrent AML with multiple myeloma in a 44-year-old male along with a PUBMED-based research of previously reported similar cases in published literature.
Equivalence in international business research: A three-step approach
Authors: Solarino Angelo M. , Buckley Peter J.
Published: October 2022

A primary research area within the field of international business (IB) is to establish the extent to which concepts, theories, and findings identified in one country are applicable to other contexts and which are unique and cannot be found in other contexts. Researchers in IB acknowledge the importance of the context in their studies, but the practice of assessing equivalence (or invariance) is not widely diffused within the community. We first discuss the components of equivalence (construct, method, and item equivalence), and we offer a three-step approach to address equivalence in the writing and revision of a paper. We aim to help editors, reviewers, and researchers produce more reliable research and navigate the tension between generalizable relationships and context-specific ones, both theoretically and empirically, before performing analysis and hypothesis testing. We then apply equivalence to the construct of firm economic performance as a case study, but the same logic can be applied to other constructs as well.
Individual excellence funding: effects on research autonomy and the creation of protected spaces
Authors: Jabrane Leila
Published: October 2022

This article contributes to the emerging body of literature which investigates the mechanisms through which funding conditions affect research. It is an interview-based case study of the Distinguished Professor Grant (DPG); an excellence funding instrument aimed at individuals. The study uses the concept of “protected space” to explore the epistemic and organizational dynamics enabled by the DPG. By virtue of their larger size and longer timeframe, excellence funding schemes are assumed to promote greater research autonomy and risk-taking, providing a “protected space”. Semi-structured interviews with DPG recipients revealed that the autonomy afforded by the funding instrument extends to three areas: epistemic, strategic, and temporal. However, this autonomy is modulated by the characteristics of the researchers and the environment in which they operate. The article concludes that, rather than involving a one-time accomplishment, enacting “a protected space” using a grant like the DPG requires constantly balancing investments and adjustments in different priority areas.
Australian Falcons
Authors: Debus Stephen
Published: October 2022

Falcons are stunning and iconic birds. Australia has six falcon species, with two endemic to the continent and two others endemic to the Australasian region. They are important indicators of the health of our ecosystems, due to their position at the top of the food chain. But several species are declining, with two species threatened in some states.
In Australian Falcons: Ecology, Behaviour and Conservation, Dr Stephen Debus provides a 30-year update of knowledge on these six species, as well as a falcon-like hawk, the Black-shouldered Kite. This book is based partly on the author’s field studies, as well as being a supplement to the Handbook of Australian, New Zealand and Antarctic Birds (HANZAB) and recent global treatises. It offers up-to-date information on the Australian species, including their behaviours, ecology and biology. It reviews their population status and threats, and suggests what needs to be done to ensure the future of these spectacular birds.
Australian Falcons is an invaluable resource for raptor biologists, birdwatchers, wildlife rescuers and carers, raptor rehabilitators and zookeepers.
Women’s experiences of, and preferences for, postpartum contraception counselling
Authors: Li Ching Kay , Botfield Jessica , Amos Natalie , Mazza Danielle
Published: October 2022

Background The lack of access to and uptake of postpartum contraception is a key contributor to an estimated 121 million unintended pregnancies worldwide. Research on counselling and women’s preferences for postpartum contraception is scarce in Australia. We therefore aimed to explore Australian women’s experiences of, and preferences for, accessing postpartum contraceptive counselling. Method In this qualitative study, English-speaking women of reproductive age (18–40 years) with at least one child under the age of 5 years were recruited via social media to participate in a semi-structured telephone interview. Interviews focussed on women’s experiences of, and preferences for, postpartum contraception. The interviews were audio-recorded, transcribed, coded and thematically analysed. Results Twenty women participated. Most did not receive in-depth contraceptive counselling antenatally or postnatally, though had brief discussions with their GPs or obstetricians at the 6-week postnatal check. Participants felt some counselling throughout their antenatal and postnatal care would have been useful, particularly those who experienced medical complications perinatally. Most participants expressed a general preference for their GP or a midwife to provide such counselling, rather than an obstetrician or nurse, and they noted characteristics such as compassion, trust and care as being particularly important. Conclusion The provision of postpartum contraceptive counselling could be enhanced in Australia. Contraceptive uptake in the postpartum period may be promoted by ensuring consistent and routine provision of contraceptive counselling for women antenatally and postnatally by their maternity carers.
Sub-pixel energy-weighting techniques for metallic contaminant highlighting in a pharmaceutical hard capsule using a Timepix3 CdZnTe hybrid pixel detector
Authors: Roque Gerardo , Schütz Michael K. , Fey Julian , Useche Juan S. , Fiederle Michael , Procz Simon
Published: October 2022

The presented work describes the capabilities of a
state-of-the-art spectroscopic photon-counting hybrid pixel detector
for use in non-destructive testing, as a contaminant detector with
potential uses in the food and pharmaceutical industries. A
pharmaceutical hard capsule containing vitamin powder, contaminated
with Steel (ST) and Tungsten (W) was prepared under controlled
conditions. Both contaminants are distinguished from the powder by
combining sub-pixel imaging with spectroscopic imaging analysis,
made possible by the use of a 2 mm CdZnTe sensor coupled to a
Timepix3 ASIC, operated in Time-over-Threshold and Time-of-Arrival
mode. The sub-pixelization technique achieves a spatial resolution
of 18.3 μm, with a maximum photon flux of
2.5× 106 photons/s· cm2. For the spectral
analysis technique implemented, each energy bin image is
energy-weighted, with weights optimally defined by considering the
bin contrast and noise behavior, and combined to form an
integrated-spectrum enhanced image with increased contaminant
visibility. Contrast-to-Noise Ratio (CNR) for each contaminant type
was used for performance assessment of the approach. A CNR increase
of 106% above the reference unweighted-spectrum image was achieved
for the ST contaminant, while the denser W contaminant showed a CNR
increase of 80%. This means that the presented spectroscopic
imaging technique is feasible for implementation in material
visibility enhancement.
A Study of Tourism Objects in Supporting Fieldwork-Based Geography Learning in Sumbermanjing Wetan, Malang Regency, Indonesia
Authors: Sahrina Alfi , Sumarmi  , Purwanto  , Rosyida Fatiya , Fadlan Muhammad Sainul , Prasetyo Devi , Withuda Febrian Arrya
Published: October 2022

Tourism objects in Malang Regency have variety of interactions in fulfilling the needs of tourists, including in Subermanjing Wetan District. Sumbermanjing Wetan District is an area that has a variety of tourism objects attractions. The purpose of this study was to analyze the environmental and social conditions in the tourism object attractions of Sumbermanjing Wetan District in supporting fieldwork-based geography learning. The method used in this research is descriptive qualitative, while data collection is done through observation and field surveys. The results of this study indicate that the Sumbermanjing Wetan sub-district has various kinds of tourism objects such as marine tourism, water tourism, cultural tourism, educational tourism, culinary tourism, and special tourism object attraction. The existing tourism objects have their own characteristics in geography learning process. The application of geography learning in tourism attraction areas can be done by conducting fieldwork based learning and university programs. Fieldwork-based geography learning is related to the study of physical, environmental, social, tourism, and cultural geography, where each location can have various objects of study to support geography learning. In college tourism objects field work, of course, there will be obstacles related to finance, security, and licensing.