bluuebunny/crossref_metadata_2025 huggingface dataset:
Establishment of the Variation of Vitamin K Status According to Vkorc1 Point Mutations Using Rat Models
Authors: Debaux Jean Valéry , Hammed Abdessalem , Barbier Brigitte , Chetot Thomas , Benoit Etienne , Lefebvre Sébastien , Lattard Virginie
Published: September 2019

Vitamin K is crucial for many physiological processes such as coagulation, energy metabolism, and arterial calcification prevention due to its involvement in the activation of several vitamin K-dependent proteins. During this activation, vitamin K is converted into vitamin K epoxide, which must be re-reduced by the VKORC1 enzyme. Various VKORC1 mutations have been described in humans. While these mutations have been widely associated with anticoagulant resistance, their association with a modification of vitamin K status due to a modification of the enzyme efficiency has never been considered. Using animal models with different Vkorc1 mutations receiving a standard diet or a menadione-deficient diet, we investigated this association by measuring different markers of the vitamin K status. Each mutation dramatically affected vitamin K recycling efficiency. This decrease in recycling was associated with a significant alteration of the vitamin K status, even when animals were fed a menadione-enriched diet suggesting a loss of vitamin K from the cycle due to the presence of the Vkorc1 mutation. This change in vitamin K status resulted in clinical modifications in mutated rats only when animals receive a limited vitamin K intake totally consistent with the capacity of each strain to recycle vitamin K.
Acceptance and Impact of Millet-Based Mid-Day Meal on the Nutritional Status of Adolescent School Going Children in a Peri Urban Region of Karnataka State in India
Authors: Anitha Seetha , Kane-Potaka Joanna , Tsusaka Takuji W. , Tripathi Deepti , Upadhyay Shweta , Kavishwar Ajay , Jalagam Ashok , Sharma Nidhi , Nedumaran Swamikannu
Published: September 2019

The study assessed the potential for use of millets in mid-day school meal programs for better nutritional outcomes of children in a peri-urban region of Karnataka, India, where children conventionally consumed a fortified rice-based mid-day meal. For a three-month period, millet-based mid-day meals were fed to 1500 adolescent children at two schools, of which 136 were studied as the intervention group and were compared with 107 other children in two other schools that did not receive the intervention. The intervention design was equivalent to the parallel group, two-arm, superiority trial with a 1:1 allocation ratio. The end line allocation ratio was 1.27:1 due to attrition. It was found that there was statistically significant improvement in stunting (p = 0.000) and the body mass index (p = 0.003) in the intervention group and not in the control group (p = 0.351 and p = 0.511, respectively). The sensory evaluation revealed that all the millet-based menu items had high acceptability, with the highest scores for the following three items: finger millet idli, a steam cooked fermented savory cake; little and pearl millet bisi belle bath, a millet-lentil hot meal; and upma, a pearl and little millet-vegetable meal. These results suggest significant potential for millets to replace or supplement rice in school feeding programs for improved nutritional outcomes of children.
Apo-14´-Carotenoic Acid Is a Novel Endogenous and Bioactive Apo-Carotenoid
Authors: Aydemir Gamze , Domínguez Marta , de Lera Angel R. , Mihaly Johanna , Törőcsik Dániel , Rühl Ralph
Published: September 2019

Carotenoids can be metabolized to various apo-carotenoids and retinoids. Apo-15´-carotenoic acid (retinoic acid, RA) is a potent activator of the retinoic acid receptor (RAR) in its all-trans- (ATRA) and 9-cis- (9CRA) forms. In this study we show firstly, that apo-14´-carotenoic acid (A14CA), besides retinoic acids, is present endogenously and with increased levels in the human organism after carrot juice supplementation rich in β-carotene. All-trans-A14C (ATA14CA) is just a moderate activator of RAR-transactivation in reporter cell lines but can potently activate retinoic acid response element (RARE)-mediated signalling in DR5/RARE-reporter mice and potently increase retinoid-reporter target gene expression in ATA14CA-supplemented mice and treated MM6 cells. Further metabolism to all-trans-13,14-dihydroretinoic acid (ATDHRA) may be the key for its potent effects on retinoid target gene activation in ATA14CA-treated MM6 cells and in liver of supplemented mice. We conclude that besides RAs, there are alternative ways to activate RAR-response pathways in the mammalian organism. ATA14CA alone and in combination with its metabolite ATDHRA may be an alternative pathway for potent RAR-mediated signalling.
PVP-H2O2 Complex as a New Stressor for the Accelerated Oxidation Study of Pharmaceutical Solids
Authors: Modhave Dattatray , Barrios Brenda , Paudel Amrit
Published: September 2019

Reactive impurities, such as hydrogen peroxide in excipients, raise a great concern over the chemical stability of pharmaceutical products. Traditional screening methods of spiking impurities into solid drug-excipient mixtures oversimplify the micro-environment and the physical state of such impurities in real dosage form. This can lead to an inaccurate prediction of the long-term product stability. This study presents the feasibility of using a polyvinylpyrrolidone-hydrogen peroxide complex (PVP-H2O2) as an oxidative agent for the solid state forced degradation of a selected drug, vortioxetine HBr. The PVP-H2O2 complex was prepared and characterized using FT-IR spectroscopy. The tablet compacts were made using a mixture of solid PVP-H2O2 complex and crystalline vortioxetine HBr powder. The compacts were exposed to 40 °C/75% RH condition in open and closed states for different time intervals. The extent and the type of drug degradation were analysed using LC and LC-MS. The extent of degradation was higher in the samples stored at the open state as compared to the close state. The solution state forced oxidation was conducted to verify the peroxide induced degradation reactions. The results evidence the utility of the proposed solid-state stressor and the method for screening the sensitivity of drugs to the excipient reactive impurities involving peroxides in solid-state.
Intracellular Delivery of siRNAs Targeting AKT and ERBB2 Genes Enhances Chemosensitization of Breast Cancer Cells in a Culture and Animal Model
Authors: Fatemian Tahereh , Moghimi Hamid Reza , Chowdhury Ezharul Hoque
Published: September 2019

Pharmacotherapy as the mainstay in the management of breast cancer suffers from various drawbacks, including non-targeted biodistribution, narrow therapeutic and safety windows, and also resistance to treatment. Thus, alleviation of the constraints from the pharmacodynamic and pharmacokinetic profile of classical anti-cancer drugs could lead to improvements in efficacy and patient survival in malignancies. Moreover, modifications in the genetic pathophysiology of cancer via administration of small nucleic acids might pave the way towards higher response rates to chemotherapeutics. Inorganic pH-dependent carbonate apatite (CA) nanoparticles were utilized in this study to efficiently deliver various classes of therapeutics into cancer cells. Co-delivery of drugs and genetic materials was successfully attained through a carbonate apatite delivery device. On 4T1 cells, siRNAs against AKT and ERBB2 plus paclitaxel or docetaxel resulted in the largest increase in anti-cancer effects compared to CA/paclitaxel or CA/docetaxel. Therefore, these ingredients were selected for further in vivo investigations. Animals receiving injections of CA/paclitaxel or CA/docetaxel loaded with siRNAs against AKT and ERBB2 possessed significantly smaller tumors compared to CA/drug-treated mice. Interestingly, synergistic interactions in target protein knock down with combinations of CA/AKT/paclitaxel, CA/ERBB2/docetaxel were documented via western blotting.
Integrating SEBAL with in-Field Crop Water Status Measurement for Precision Irrigation Applications—A Case Study
Authors: Gobbo Stefano , Lo Presti Stefano , Martello Marco , Panunzi Lorenza , Berti Antonio , Morari Francesco
Published: September 2019

The surface energy balance algorithm for land (SEBAL) has been demonstrated to provide accurate estimates of crop evapotranspiration (ET) and yield at different spatial scales even under highly heterogeneous conditions. However, validation of the SEBAL using in-field direct and indirect measurements of plant water status is a necessary step before deploying the algorithm as an irrigation scheduling tool. To this end, a study was conducted in a maize field located near the Venice Lagoon area in Italy. The experimental area was irrigated using a 274 m long variable rate irrigation (VRI) system with 25-m sections. Three irrigation management zones (IMZs; high, medium and low irrigation requirement zones) were defined combining soil texture and normalized difference vegetation index (NDVI) data. Soil moisture sensors were installed in the different IMZs and used to schedule irrigation. In addition, SEBAL-based actual evapotranspiration (ETr) and biomass estimates were calculated throughout the season. VRI management allowed crop water demand to be matched, saving up to 42 mm (−16%) of water when compared to uniform irrigation rates. The high irrigation amounts applied during the growing season to avoid water stress resulted in no significant differences among the IMZs. SEBAL-based biomass estimates agreed with in-season measurements at 72, 105 and 112 days after planting (DAP; r2 = 0.87). Seasonal ET matched the spatial variability observed in the measured yield map at harvest. Moreover, the SEBAL-derived yield map largely agreed with the measured yield map with relative errors of 0.3% among the IMZs and of 1% (0.21 t ha−1) for the whole field. While the FAO method-based stress coefficient (Ks) never dropped below the optimum condition (Ks = 1) for all the IMZs and the uniform zone, SEBAL Ks was sensitive to changes in water status and remained below 1 during most of the growing season. Using SEBAL to capture the daily spatial variation in crop water needs and growth would enable the definition of transient, dynamic IMZs. This allows farmers to apply proper irrigation amounts increasing water use efficiency.
Development and Application of Aptamer-Based Surface-Enhanced Raman Spectroscopy Sensors in Quantitative Analysis and Biotherapy
Authors: Wang Hai-Xia , Zhao Yu-Wen , Li Zheng , Liu Bo-Shi , Zhang Di
Published: September 2019

Surface-enhanced Raman scattering (SERS) is one of the most special and important Raman techniques. An apparent Raman signal can be observed when the target molecules are absorbed onto the surface of the SERS substrates, especially on the “hot spots” of the substrates. Early research focused on exploring the highly active SERS substrates and their detection applications in label-free SERS technology. However, it is a great challenge to use these label-free SERS sensors for detecting hydrophobic or non-polar molecules, especially in complex systems or at low concentrations. Therefore, antibodies, aptamers, and antimicrobial peptides have been used to effectively improve the target selectivity and meet the analysis requirements. Among these selective elements, aptamers are easy to use for synthesis and modifications, and their stability, affinity and specificity are extremely good; they have been successfully used in a variety of testing areas. The combination of SERS detection technology and aptamer recognition ability not only improved the selection accuracy of target molecules, but also improved the sensitivity of the analysis. Variations of aptamer-based SERS sensors have been developed and have achieved satisfactory results in the analysis of small molecules, pathogenic microorganism, mycotoxins, tumor marker and other functional molecules, as well as in successful photothermal therapy of tumors. Herein, we present the latest advances of the aptamer-based SERS sensors, as well as the assembling sensing platforms and the strategies for signal amplification. Furthermore, the existing problems and potential trends of the aptamer-based SERS sensors are discussed.
Improving Phosphorus Use Efficiency and Optimizing Phosphorus Application Rates for Maize in the Northeast Plain of China for Sustainable Agriculture
Authors: Jiang Wenting , Liu Xiaohu , Wang Xiukang , Yang Lihui , Yin Yuan
Published: September 2019

Optimizing the phosphorus (P) application rate can increase grain yield while reducing both cost and environmental impact. However, optimal P rates vary substantially when different targets such as maximum yield or maximum economic benefit are considered. The present study used field experiment conducted at 36 experiments sites for maize to determine the impact of P application levels on grain yield, plant P uptake, and P agronomy efficiency (AEP), P-derived yield benefits and private profitability, and to evaluated the agronomically (AOPR), privately (POPR), and economically (EOPR) optimal P rate at a regional scale. Four treatments were compared: No P fertilizer (P0); P rate of 45–60 kg ha−1 (LP); P rate of 90–120 kg ha−1 (MP); P rate of 135–180 kg ha−1 (HP). P application more effectively increased grain yield, reaching a peak at MP treatment. The plant P uptake in HP treatment was 37.4% higher than that in P0. The relationship between P uptake by plants (y) and P application rate (x) can be described by the equation y = −0.0003x2 + 0.1266x + 31.1 (R2 = 0.309, p < 0.01). Furthermore, grain yield (y) and plant P uptake (x) across all treatments also showed a significant polynomial function (R2 = 0.787–0.846). The MP treatment led to highest improvements in P agronomic efficiency (AEP), P-derived yield benefits (BY) and private profitability (BP) compared with those in other treatments. In addition, the average agronomically (AOPR), privately (POPR), and economically optimal P rate (EOPR) in 36 experimental sites were suggested as 127.9 kg ha−1, 110.8 kg ha−1, and 114.4 kg ha−1, which ranged from 80.6 to 211.3 kg ha−1, 78.2 to 181.8 kg ha−1, and 82.6 to 151.6 kg ha−1, respectively. Economically optimal P application (EOPR) can be recommended, because EOPR significantly reduced P application compared with AOPR, and average economically optimal yield was slightly higher compared with the average yield in the MP treatment. This study was conducive in providing a more productive, use-effective, profitable, environment-friendly P fertilizer management strategy for supporting maximized production potential and environment sustainable development.
Multi-Power Joint Peak-Shaving Optimization for Power System Considering Coordinated Dispatching of Nuclear Power and Wind Power
Authors: Liu Qi , Zhao Jie , Shao Youguo , Wen Libin , Wu Jianxu , Liu Dichen , Ma Yuhui
Published: September 2019

The matching characteristics of wind power output and nuclear power peak shaving are studied and the influence of coordinated dispatching of wind power and nuclear power on peak shaving flexibility and cost of the power grid is analyzed. Taking the lowest total operation cost of the system as the objective and considering the operation constraints, peak shaving cost of nuclear power units and the abandoned wind cost, a multi-power dispatching model for power system is proposed. In addition, in order to accurately optimize the output of nuclear power, a method of subdividing the peak shaving depth of nuclear power to linearize the constraint of nuclear power peak shaving is proposed. The analysis of example shows that the multi-power dispatching model considering the coordinated operation of wind and nuclear power has a high operation economy and can significantly reduce the amount of wind abandonment. The daily load tracking mode can be used for the participation of nuclear power units in daily peak shaving and the feasibility and necessity of coordinated wind-nuclear dispatching are verified.
The Socioeconomic Impact of Tourism in East Kazakhstan Region: Assessment Approach
Authors: Aliyeva Selvina , Chen Xi , Yang Degang , Samarkhanov Kanat , Mazbayev Ordenbek , Sekenuly Aday , Issanova Gulnura , Kozhokulov Sadyrbek
Published: September 2019

The article presents a methodical approach based on an integrated assessment of the social and economic impacts of tourism for East Kazakhstan Region. The assessment was done using indicators such as the number of tourists, accommodation units, tourism facilities’ billing, and other statistical data for the period of 2009–2018. Integrated assessment performed using weighted sums of considered parameters and ordinary least squares linear regression method is applied for effectiveness prediction. Applied approaches of arithmetic (calculated) and multivariate regression modeling of the integral tourism efficiency demonstrated the same results, which mean the approach can be transferred and applied for other regions of Kazakhstan. Growing trends in tourism efficiency are derived and conclusions made on their importance for regional development. The economic and social impacts of tourism in East Kazakhstan Region increased significantly during the period from 2003 to 2018.
The Carbon Footprint of Energy Consumption in Pastoral and Barn Dairy Farming Systems: A Case Study from Canterbury, New Zealand
Authors: Ilyas Hafiz Muhammad Abrar , Safa Majeed , Bailey Alison , Rauf Sara , Pangborn Marvin
Published: September 2019

Dairy farming is constantly evolving to more intensive systems of management, which involve more consumption of energy inputs. The consumption of these energy inputs in dairy farming contributes to climate change both with on-farm emissions from the combustion of fossil fuels, and by off-farm emissions due to production of farm inputs (such as fertilizer, feed supplements). The main purpose of this research study was to evaluate energy-related carbon dioxide emissions, the carbon footprint, of pastoral and barn dairy systems located in Canterbury, New Zealand. The carbon footprints were estimated based on direct and indirect energy sources. The study results showed that, on average, the carbon footprints of pastoral and barn dairy systems were 2857 kgCO2 ha−1 and 3379 kgCO2 ha−1, respectively. For the production of one tonne of milk solids, the carbon footprint was 1920 kgCO2 tMS−1 and 2129 kgCO2 tMS−1, respectively. The carbon emission difference between the two systems indicates that the barn system has 18% and 11% higher carbon footprint than the pastoral system, both per hectare of farm area and per tonne of milk solids, respectively. The greater carbon footprint of the barn system was due to more use of imported feed supplements, machinery usage and fossil fuel (diesel and petrol) consumption for on-farm activities.
Molecular Regulation of Host Defense Responses Mediated by Biological Anti-TMV Agent Ningnanmycin
Authors: An Mengnan , Zhou Tao , Guo Yi , Zhao Xiuxiang , Wu Yuanhua
Published: September 2019

Ningnanmycin (NNM) belongs to microbial pesticides that display comprehensive antiviral activity against plant viruses. NNM treatment has been shown to efficiently delay or suppress the disease symptoms caused by tobacco mosaic virus (TMV) infection in local-inoculated or systemic-uninoculated tobacco leaves, respectively. However, the underlying molecular mechanism of NNM-mediated antiviral activity remains to be further elucidated. In this study, 414 differentially expressed genes (DEGs), including 383 which were up-regulated and 31 down-regulated, caused by NNM treatment in TMV-infected BY-2 protoplasts, were discovered by RNA-seq. In addition, KEGG analysis indicated significant enrichment of DEGs in the plant–pathogen interaction and MAPK signaling pathway. The up-regulated expression of crucial DEGs, including defense-responsive genes, such as the receptor-like kinase FLS2, RLK1, and the mitogen-activated protein kinase kinase kinase MAPKKK, calcium signaling genes, such as the calcium-binding protein CML19, as well as phytohormone responsive genes, such as the WRKY transcription factors WRKY40 and WRKY70, were confirmed by RT-qPCR. These findings provided valuable insights into the antiviral mechanisms of NNM, which indicated that the agent induces tobacco systemic resistance against TMV via activating multiple plant defense signaling pathways.
A Cellular Model of Infection with Brucella melitensis in Ovine Macrophages: Novel Insights for Intracellular Bacterial Detection
Authors: Karponi Garyfalia , Kritas Spyridon K. , Papanikolaou Eleni , Petridou Evanthia
Published: September 2019

Intracellular bacteria provoking zoonoses, such as those of the genus Brucella, present a host cell tropism mostly limited to the monocyte/macrophage lineage, leading to chronic inflammatory reactions, difficult-to-eradicate-infections, and widespread prevalence among ruminants. Eradication of brucellosis has been based on programs that translate into a substantial financial burden for both the authorities and stockbreeders, if not strictly followed. To this end, we sought to create an in vitro cell model that could be utilized as future reference for adequately measuring the number of engulfed brucellae/cell, using peripheral blood-derived sheep macrophages infected with B. melitensis at decimal multiplicities of infection (MOI = 5000-5), to simulate the host cell/microorganism interaction and monitor bacterial loads up to 6 days post-infection. We show that the MOI = 5000 leads to high numbers of engulfed bacteria without affecting macrophages’ viability and that the minimum detection limit of our Real-Time PCR assay was 3.97 ± 5.58 brucellae/cell. Moreover, we observed a time-associated, significant gradual reduction in bacterial loads from Day 2 to Day 6 post-infection (p = 0.0013), as part of the natural bactericidal properties of macrophages. Overall, the work presented here constitutes a reliable in vitro cell model of Brucella melitensis for research purposes that can be utilized to adequately measure the number of engulfed brucellae/cell and provides insights towards future utilization of molecular biology-based methods for detection of Brucella.
Dynamic Analysis and Design of a Novel Ring-Based Vibratory Energy Harvester
Authors: Gebrel Ibrahim F. , Wang Ligang , Asokanthan Samuel F.
Published: September 2019

This paper aims to focus on the design and analysis of a novel ring-based mono-stable energy-harvesting device that is considered as an alternative to the beam and tube models used thus far. The highly sensitive ring second flexural mode, when combined with the nonlinear external magnetic force, results in an ideal combination that yields increased frequency range, and can be considered as novel in the field of vibration-based energy harvesters. A mathematical model for the ring structure, as well as a model to generate nonlinear magnetic force that acts on the ring structure, is formulated. The discretized form of the governing equations is shown to represent a Duffing oscillator in the presence of an external magnetic field. The forms of the system potential energy, as well as the restoring force, are examined to ensure that the mono-stable behavior exists in the proposed model. Numerical predictions of time response, frequency response, phase diagram, and bifurcations map when the system is subjected to ambient harmonic excitation, have been performed for the purposes of gaining an insight into the dynamics and power generation of this new class of harvesters.
Risky Business: Peripheral and Central Venous Catheters Both Pose Risks
Authors: Hathaway Lynette , Magee Mary
Published: September 2019

Venous access is an essential method of providing life-saving therapy. As part of intensive efforts to decrease the incidence of central line–associated bloodstream infections (CLABSIs), healthcare facilities may be increasing the use of short (noncentral) peripheral venous catheters (PVCs). To investigate this, the Patient Safety Authority (PSA) sought to explore the relationship of actual to predicted complications per central venous catheters (CVCs) and PVCs over a nine-year period. In addition, as PVCs are not without risk and CVCs pose risks aside from infection, we sought to identify the type and relationship of PVC to CVC complications and to quantify the timing and types of PVC and CVC complications and their associated risk factors.

A query of the PSA’s statewide event reporting database, the Pennsylvania Patient Safety Reporting System (PA-PSRS), for venous catheter complication events and a query of the National Healthcare Safety Network (NHSN) database for both primary bloodstream infections (BSIs) and CLABSIs occurring at inpatient facilities from January 1, 2009, through December 31, 2017, yielded 115,937 events. A methodical sampling of PA-PSRS yielded 2,413 PVC and CVC events. These were analyzed for the timing of complications reported, the type of complication reported, and any identified risk factors.

Overall reports of PVC complications increased, and the correlation between actual and predicted PVC events over the nine years studied is strong and statistically significant. The slight decrease in the number of reported CVC complications was not statistically significant. The authors used regression analysis to determine the best-fitting line through the predicted and actual observed events during the period of observation. These data are not intended to present a predictive model of future events. No correlation was found between the numbers of PVC and CVC complications.

The greatest number of PVC complications, particularly infiltration, occurred during catheter maintenance. Excluding NHSN-reported CLABSIs, the greatest number of CVC complications, particularly pneumothorax, occurred during catheter insertion.

Education and training are key to preventing intravascular device–associated complications. Healthcare facilities are encouraged to evaluate policy, procedures, and actual practices to eliminate complications and improve outcomes. In addition, quality improvement efforts aimed at decreasing CLABSIs should include measuring CVC complications and all PVC complications as a balancing metric.
BREVE ESTUDO INTERDISCIPLINAR ACERCA DA EVOLUÇÃO, ONTOGENIA E COGNIÇÃO DO COMPORTAMENTO RITUAL
Authors: Silva Thales Moreira Maia , Dos Santos Lucas Soares
Published: September 2019

Esse estudo argumenta que apesar da capacidade de realizar atividades rituais ser uma pré-disposição psicológica humana, tal tipo de prática é um registro comportamental culturalmente herdado por nossa espécie. A partir dessa perspectiva, buscaremos realizar uma análise das estruturas e funções psicossociais dos rituais, tratando-as como selecionadas por (e transmitidas por meio de) processos de desenvolvimento cultural. Dessa forma, nosso primeiro objetivo será descrever as funções sociais dos rituais conforme sua ação interna aos grupos humanos. Com isso, buscaremos demonstrar que o comportamento ritual auxilia na resolução de problemas adaptativos associados com a manutenção dos agrupamentos sociais. Nesse contexto, tentaremos prover um relato psicológico de como a estrutura ritual pode ter, com o tempo, auxiliado na transmissão de aspectos culturais e, em seguida, analisaremos estudos que apontam para a realização de práticas rituais como motivadas por ameaças de exclusão social e perda de status ante aos componentes de um grupo. Em conclusão, na parte final desse estudo, realizaremos uma breve análise psicossocial da ontogenia da cognição ritual.
Travis Bickle em (re)construção na enunciação fílmica: uma análise dialógica do sujeito protagonista de Taxi Driver (1976)
Authors: Moura Lizandra Belarmino de
Published: September 2019

Há uma urgência em se pensar o sujeito inserido em uma “malha bordada” por diversos discursos contraditórios em circulação, que, consequentemente reverberam em suas ações e, especialmente, em seus enunciados. Nesta pesquisa é analisado, descrito e interpretado enunciados verbovocovisuais eleitos a partir da narrativa fílmica de Taxi Driver (1976), de Martin Scorsese, com a finalidade de compreender como se dá a transformação e movimentação do sujeito Travis Bickle (Robert De Niro). Partindo, assim, da hipótese de que as relações dialógicas entre ele e os “outros” que o circundam são relevantes e reveladores para entender a construção da enunciação fílmica e, consequentemente, da construção/transformação desse sujeito. O aporte teórico e metodológico vem da teoria dialógica da linguagem do Círculo de Bakhtin. Assim, ao cotejar conceitos com os recortes de cenas feitos, compreendemos como se dá a construção do sujeito que é transpassado por seu contexto sócio-histórico e ideológico, enquanto reflete e refrata a sua realidade, pois traços de contrariedade foram percebidos nos discursos que permeiam Travis e isso porque, os enunciados são as arenas discursivas em que os discursos entram em conflito.
FORMAS ORGANIZATIVAS E TRANSBORDAMENTO SOCIETÁRIO NA ONDA DE PROTESTOS DE JUNHO DE 2013
Authors: Tury João Gabriel
Published: September 2019

A onda de protestos de junho de 2013 destacou-se por ser um dos maiores processos de mobilização da história do país e por desenvolver repertórios de confronto distintos dos predominantes nas grandes manifestações do passado. Este artigo analisa como a forma organizativa da fase inicial da onda de protestos influenciou a difusão da mobilização e as inovações de repertório, elementos presentes no processo de transbordamento societário que caracteriza a segunda fase dos protestos. A análise se concentra na forma de organização implementada pelo Movimento Passe Livre – São Paulo, de 06 a 13 de junho, pela qual constata-se a construção de uma relação inorgânica entre manifestantes e movimento, alicerçada numa ideologia de influência autonomista que prioriza a tática em detrimento do projeto estratégico. Com isso, conclui-se que a forma organizativa utilizada pelo MPL em São Paulo, ao rejeitar construir um projeto estratégico de disputa hegemônica, foi um fator de influência no rumo tomado pela inflexão da onda de protestos, facilitando sua difusão e a quebra do enquadramento unitário.
À PORTA DAS CELAS: A RESSIGNIFICAÇÃO DO ‘EU’ ATRAVÉS DA INFLUÊNCIA DO DISCURSO RELIGIOSO NA PRISÃO
Authors: Carvalho Nunes Ana Idalina
Published: September 2019

Este artigo analisa o efeito do discurso religioso na ressignificação do eu de homens que cumprem pena no presídio de Cataguases (MG) e avalia o impacto dessa ressignificação sobre o comportamento desses homens, dentro e fora das celas. O estudo tem como base teórica principal o interacionismo simbólico  de  Goffman e a análise do discurso francesa de Pêcheux por Eni Orlandi, mas também recorre às teorias de Althusser e de Marcuse para discutir o aparente paradoxo que existe entre a hipótese de ressignificação do eu a partir do discurso religioso e o posicionamento da religião como aparelho ideológico de Estado. O estudo foi desenvolvido a partir de  duas incursões:  a primeira na escola prisional (2012-2013), da qual se utiliza aqui a antologia “Poetas da liberdade” organizada a partir da produção poética dos alunos; a segunda, realizada dentro das galerias do presídio entre abril e agosto de 2016 e em fevereiro de 2017, através de entrevistas e da observação participante, permite a identificação situações que se configuram como ‘mortificação do eu’ e que caracterizam o presídio como instituição total. Como resultado, são identificadas quatro formas básicas de ressignificação do eu pelo discurso religioso, que vão alterar a percepção que esses  homens  têm de  si mesmos, dos outros e, consequentemente, do mundo.
El manejo del agua en la cuenca inferior de Miriguaca (Antofagasta de la Sierra): diseño de red y tecnologías hidráulicas prehispánicas
Authors: Grana Lorena , Quesada Marcos , Gasparotti Leticia
Published: September 2019

En este trabajo se presentan nuevas evidencias sobre las tecnologías paleohidráulicas de la red de riego de Miriguaca 1 (MS1) localizada en Antofagasta de la Sierra (Catamarca). Estas evidencias permiten profundizar sobre las interpretaciones del funcionamiento y los diseños hidráulicos de las redes conocidas hasta el momento en la Puna meridional argentina. A través de análisis de imágenes satelitales y de controles pedestres se logró identificar una gran cantidad de campos de cultivo y canales e incluso sus modificaciones. También se detectó el uso de una represa de riego, la cual constituye la primera evidencia de esta naturaleza para la Puna meridional. Este dispositivo hídrico habría permitido la acumulación de agua para una mayor extensión de riego y un control sobre el tiempo para el uso del agua. En base al material arqueológico vinculado a la red de riego y su diseño se discute la cronología de su construcción y sus modos de uso.
Aportes a la Arqueología reduccional. El caso de Nuestra Señora de Ibitiracuá (Concepción de la Sierra, Misiones, Argentina)
Authors: Ocampo Amanda E. , Richard Alejandro , Sastre Yamila , Candelario Soledad
Published: September 2019

A partir de los primeros trabajos arqueológicos que se vienen realizando en el casco histórico de la localidad de Concepción de la Sierra (provincia de Misiones, Argentina), antiguo emplazamiento de la reducción jesuítica-guaraní Nuestra Señora de Ibitiracuá, y el análisis preliminar de los materiales recuperados en distintos sondeos, se discuten los datos obtenidos en relación a antecedentes regionales para momentos pre y post-hispánicos. Se plantea el análisis de los atributos formales de las evidencias recuperadas en estas primeras intervenciones con el objetivo de identificar las características presentes en los materiales que se preservaron bajo la superficie, a pesar del alto dinamismo y disturbación del contexto arqueológico. Los resultados hasta ahora obtenidos avalan por un lado, la periodicidad de diferentes momentos históricos y por otro, la continuidad en determinados estilos cerámicos que se observa para tiempos prehispánicos. Por último, se discute el alto grado de reutilización espacial y material, como así también el rol de nuestra disciplina en torno a un patrimonio vivo y dinámico amenazado por la creciente urbanización.
Examination of resistance against Aeromonas hydrophila infection on genetically different common carp variants (preliminary results)
Authors: Ardó László , Bakos János , Nagy Zoltán Tamás , Rónyai András , Gál Dénes , Bercsényi Miklós , Gjerde Bjarne , Olesen Ingrid , Jeney Galina , Jeney Zsigmond
Published: September 2019

Septicemia disease caused by the bacterium Aeromonas hydrophila is a major problem for fish farmers around the world. In our experiment resistance to the disease was investigated on carp variants with diferent genetical backgrounds. 96 different genetic variants(„families”) were created by crossing various individuals of 4 carp strains (2 wild and 2 cultured ones). Families were reared until reaching the size of 10 gramms and 100 fish of each families were marked with an individual electronic identifier. Marked fish were divided into 5 groups. Fish from one group were infected with A. hydrophila and mortality were registered during 2 weeks. Based on mortality data, the most resistant and most susceptible families will be selected using population genetics methods.
IMPLEMENTASI PENDIDIKAN KARAKTER ANAK USIA DINI DI RA SABILUL HUDA DESA LABAN MENGANTI GRESIK
Authors: Syaikhon Muhammad
Published: September 2019

This research is the kind of research the field with the approach descriptive qualitative with the title the implementation of character education early childhood in RA Sabilul Huda Laban Menganti Gresik. This research aims to review the process of implementation of character education on early childhood in RA Sabilul Huda Laban Menganti Gresik and to know the supporting factors and the inhibitors. Technique of data collection is  by observation, in-depth interviews, and documentation. Analysis of data is with three stages, the reduction of data , presentation of data, and withdrawal conclusions/ verification

These research findings can be concluded that the implementation of character education early childhood in RA Sabilul Huda Laban Menganti Gresik is through three rounds of including planning, implementation, and evaluation. The planning in the process of the implementation of characters education is begun by inserting the character values into the school curriculum, annual program, semester program, Program of Learning Plan weekly/Rencana Program Pembelajaran Mingguan (RPPM), and Program of Learning Plan dayly Rencana Program Pembelajaran Harian (RPPH). The process of implementation of character education is integrated in learning activities , exemplary, and habit.While the scoring in the process of applying character education integrated in the assessment of learning and spontaneous assessment conducted by educator.

In the process of the implementation of character education in RA Sabilul Huda there are factors that support and inhibit. The factors that support the implementation of the character education are the charge of character education in the school curriculum, the motivations of school for the quality of output, the infrastructure that supports for the implementation of character education is enough. While the factors that inhibits the implementation of the character education are different characteristic students, the different environmental of students, the funding of character education still charged fully to the school, the students readily not focus, and the monitoring of the center of curriculum is not enough.
MODEL PENGEMBANGAN KURIKULUM MULTIKULTURAL
Authors: Ramdhan Tri Wahyudi
Published: September 2019

This research discuss about curriculum development of multicultural. The discussions about curriculum development are very diverse which consists of elements (1) planning;  (2) implementation (3) evaluation.  But in this research, not all elements of curriculum development are a concern, but will only be focused on the curriculum planning element done by SMA 1 Kediri.  This research uses a qualitative approach to the type of case study.  Whereas in collecting data using participatory observation, in-depth interviews and documentation.  And the data collected was analyzed using an interactive analysis model.  The results of this research show that curriculum planning in SMA 1 uses a parallel model through three stages, namely (1) strategic planning, (2) program planning and (3) planning of learning activities by producing products containing multicultural dimensions through processes that also contain dimensions  multicultural
KAJIAN BERBAGAI TIPE PENGELOLAAN WILAYAH SUNGAI DI ASIA SEBAGAI ACUAN DALAM PENENTUAN SISTEM PENGELOLAAN SUMBER DAYA AIR
Authors: SURYA DEWI NI MADE NIA BUNGA
Published: September 2019

The  Integrated Water Resources Management (IWRM)  is  significant  to do  in order  to obtain water  supply availability including inter-sector perspective, diverse of  water future needs, and  its present availability and  orientation  towards  the  'triple bottom  line',  such as  social, economi,c and environment.  In  the past decade,  most  countries  in Asia  have  already  adopted  national water  policies  that  advocate  IWRM  in  river  basins.  However, IWRM implementation is still at an early stage. IWRM at the basin level is best provided by a River Basin Organization (RBO)  by facilitating  and/ or implementing  various  development  processes   and  management.  Across Asia, a variety of small and large RBOs are now helping governments and stakeholders to implement IWRM in river basins.  Some RBOs operate within the structures of regular government departments. In  other  cases,  however,  a  corporate  or  quasi-corporate model  has  been  selected,  to  provide  RBOs  with  greater  autonomy  in  their  management,  capacity  development,  and  revenue  generation.  The research attempts to  study distinction between  three  types of RBO: council/committee, public/ government,  and  corporation. Thus, it can determine  the most  appropriate  type  of  river management  applied  in  river  basin
PEMBERDAYAAN MASYARAKAT MELALUI PENGEMBANGAN DESA WISATA DENGAN KONSEP CBT (COMMUNITY BASED TOURISM) DI DESA LABUAN PANDAN
Authors: ARYAWAN ASASANDI I GUSTI NGURAH , AFZAL MUHAMMAD
Published: September 2019

Tourism is one of the promising business sectors, if local people can see well the potential available around their neighborhood. With the position of the country of Indonesia which is located on the equator which causes diverse types of flora and fauna, as well as the archipelago's topography providing a stretch of both coastal and cultural diversity available, it is no wonder that tourism opportunities are still wide open to be developed. Labuan Pandan Village is a coastal village with 2 (two) dykes in the east, so that it becomes a magnet for tourists who want to see first hand the beauty of coral reefs and mangrove ecosystems. Tourism stretching has begun to be seen in the activity of tourism activists who joined a community called KOMPAK (Labuan Pandan Kreatif Youth Community). The concept of CBT (Community Based Tourism) has been started by the KOMPAK community since 2017 and of course since then the people in Labuan Pandan Village are involved in the tour activities.   This study aims (1) To examine the process of empowering local communities with the concept of CBT (Community Based Tourism), (2) Constraints faced by the community in conducting tourism activities with the concept of CBT (Community Based Tourism) in Labuan Pandan Village. This research method uses descriptive method with a qualitative approach; the data used are primary and secondary. Primary data obtained from interviews and observations. The results showed that: (1) Community empowerment activities through village tourism with the concept of CBT (Community Based Tourism) went very well. This is indicated by the high level of community participation in existing tourism activities. This includes preparing accommodation, culinary, cultural arts performances and participating in educational learning activities (Educational Tourism), (2) Constraints faced by the community, that is, they have not mastered fluent foreign languages, so that they are quite inhibiting information disclosure.
ANALISIS PERUBAHAN STRUKTUR LEMBAGA NEGARA DAN SISTIM PENYELENGGARAAN KEKUASAAN NEGARA REPUBLIK INDONESIA BERDASARKAN UNDANG-UNDANG DASAR 1945 SEBELUM DAN SESUDAH AMANDEMEN
Authors: MZ H. ISMAIL
Published: September 2019

The amendment to the 1945 Constitution after the 1998 reform is based on the experience of the practice of state administration by the old and new order governments which are often referred to as authoritarian government systems, both overt and covert. The 1945 Constitution indeed gives enormous power to the President, both Sukarno and Suharto. Weaknesses contained in the 1945 Constitution that triggers the birth of the demands of the reformists to make amendments to the 1945 Constitution, especially concerning the power and term of office of the President. It is important to realize that after the 1945 Constitution is amended, it has very basic implications for the structure of the Republic of Indonesia. Before the amendment to the 1945 Constitution the existing state institutions are the People's Consultative Assembly, the President, the People's Representative Council, the Supreme Consultative Council, the Supreme Audit Board and the Supreme Court, whose titles are divided into two, namely the highest state institutions which are embedded in the People's Consultative Assembly, and the other is a high-level state institution.   After changes or amendments to the 1945 Constitution from 1999 to 2002 have implications for changes in the structure of existing state institutions and the number becomes more than before the change. The state institutions after the change are explicitly mentioned in the nomenclature such as: the People's Consultative Assembly, the House of Representatives, the Regional Representative Council, the Regional People's Representative Council, the President and Vice President, the Minister (Specially the Minister of the Interior, the Minister of Foreign Affairs and the Minister of Defense ) Governor, Regent, Mayor, Indonesian National Army, Republic of Indonesia National Police, Supreme Court, Constitutional Court, Judicial Commission and Supreme Audit Board. While there are other state institutions whose nomenclature is not mentioned explicitly namely; Advisory Council, Election Commission and Central Bank. As a consequence of the amendment to the 1945 Constitution, the constitutional system adopted has also changed. If before the change to the constitutional system adopted is the cameral union representative system, but after the change into the bicameral system, some even called it tri kameral
PENGARUH MODEL PEMBELAJARAN INKUIRI HIPOTETIK TERHADAP KETERAMPILAN BERPIKIR KRITIS DAN KETERAMPILAN PROSES SAINS SISWA SMP
Authors: KUSMIANTI KUSMIANTI
Published: September 2019

The purpose of this research is to analyze: (1) the difference of critical thinking skills (CTS) and science process skills(SPS) between student’s group who are managed with hypothetical inquiry model and conventional learning model, (2) the difference of critical thinking skills (CTS) between student’s group who are managed with hypothetical inquiry model and conventional learning model, (3) the difference of science process skills (SPS) between student’s group who are managed with hypothetical inquiry model and conventional learning model.    This research is quasi experiments with post-test only control group design factorial 2x1. Data of critical think skill are collected by using test and data of science process skillscollected by using test and observation. Data analyzed by using descriptive analyze and one way MANOVA.It is found: (1) there is significant difference of critical thinking skills (CTS) and science process skills(SPS) between student’s group who are managed with hypothetical inquiry model and conventional learning model (F=59,161; p<0,05), (2) there is significant difference of critical thinking skills (CTS) between student’s group who are managed with hypothetical inquiry model and conventional learning model(F=22,219; p<0,05), (3) there is significant difference of science process skills (SPS) between student’s group who are managed with hypothetical inquiry model and conventional learning model (F=113.559; p<0,05).
KEDUDUKAN HAKIM AD-HOC PADA PENGADILAN TIPIKOR (TINDAK PIDANA KORUPSI) DITINJAU DARI UNDANG-UNDANG NOMOR 48 TAHUN 2009 TENTANG KEKUASAAN KEHAKIMAN
Authors: APRIANI TITIN
Published: September 2019

This research is a library research that uses data in the form of books, laws, articles, journals and other literature related to the title, while the technique and data collection is by collecting various ideas, theories and concepts of various literature that are centered on the process of comparison between the evidence or other laws. The results of the study concluded that the ruling of the Constitutional Court against the position of the ad hoc judge is appropriate because it gives the same position on a different matter precisely caused injustice.   In addition to having the authority to check, prosecute, and break the criminal corruption, adhoc judges also have the authority to examine the criminal case of money laundering that the original criminal act is a corruption crime. So here corruption as the original criminal act is often referred to as predicate crimes. It is no less important that the role and authority of the adhoc judge specialising in the association of article 6 letter c The authority of the Court of Law to handle a strict follow-up in another law is determined as a corruption criminal act
Rozmieszczenie Allium scorodoprasum (Amaryllidaceae) w dolinie środkowej Odry (Polska południowo-zachodnia)
Authors: Kazienko Aleksandra , Torzewski Karol
Published: September 2019

Allium scorodoprasum (Amaryllidaceae) is a vulnerable, red-listed species in Poland, where it has an uneven distribution. In the southwestern part of the country it has not been confirmed since 1961–1975 in the majority of the former areas of its occurrence. The paper describes 48 localities of A. scorodoprasum and provides data on population size, occupied habitats, plant communities and threats in the section of the Oder Valley between Oława, Wrocław and Brzeg Dolny in Lower Silesia (SW Poland).