bluuebunny/crossref_metadata_2025 huggingface dataset:
Monitoring of Hemophilia A in Morocco
Authors: Chraibi Amina , Mamad Hassane , Edderdouri Khalid , Ganhoutode Adjimon , Benkirane Souad , Masrar Azlarab
Published: May 2024

Hemophilia A is a hemorrhagic disorder caused by a deficiency in factor VIII coagulation. Its incidence is 1 to 2 per 10,000 male births. Hemophilia A is characterized by intra-articular, mucosal, or cutaneous bleeding, and its management relies on the substitution of factor VIII with plasma derived or recombinant products. However, the major complication of treatment is the development of anti-factor VIII inhibitors, rendering substitution therapy ineffective. The aim of this study is to investigate the prevalence of anti-factor VIII inhibitors, the severity of hemophilia, and the follow-up of hemophilia patients developing anti-FVIII inhibitors in a hemophiliac population by presenting their epidemiological and biological characteristics. We conducted a retrospective descriptive cross-sectional study at the Central Hematology Laboratory of the Ibn Sina Hospital Center in Rabat (Morocco) over a period of 37 months, from December 1, 2020, to December 31, 2023. The study included 172 hemophilia A patient, with a mean age of 25 years. 55 patients developed anti-FVIII inhibitors (32%). The majority of positive inhibitor hemophiliacs were severe hemophiliacs (87%), including 23 cases of low responders (42%) and 32 cases of high responders (58%). The results obtained partly agree with most national studies (H. Mamad 2021, Y. El Aissaoui 2016, and F. Zizi in 2011), and international ones. However, the development of inhibitors varies from one individual to another according to several criteria (genetic and non-genetic).
Sister Mary Joseph Nodule: A Dermatological Insight into Metastatic Pancreatic Cancer
Authors: Ibtissam Bounouar , Mouna Elbouathmani , Chama El Manjra , Oussama Nacir , Ezzahra Lairani Fatima , Adil, Ait Errami , Sophia Oubaha , Zouhour Samlani , Khadija Krati
Published: May 2024

The Sister Mary Joseph (SMJ) nodule is a metastatic umbilical growth observed in primary tumors originating from the gastrointestinal or genitourinary tract. Commonly, SMJ nodules are associated with gastrointestinal cancers, particularly those affecting the stomach and colon. While the pancreas is an uncommon primary site for umbilical metastasis, pancreatic adenocarcinoma that spreads to the umbilicus typically originates from the body or tail of the pancreas. The presence of an SMJ nodule often indicates a poor prognosis, serving as a straightforward physical indicator of advanced intra-abdominal malignancy. Although pancreatic cancer is a rare cause, it should be considered among the primary sites in such cases. This report details a case of an SMJ nodule unveiling pancreatic adenocarcinoma in a 61-year-old patient. The case underscores the significance of examining the umbilicus, an area frequently overlooked but crucial for diagnosis. Vigilant clinical follow-up and histological evaluation are imperative in such cases, highlighting the importance of not underestimating this infrequently assessed region.
Intestinal intramural hematoma: A rare complication of Anticoagulation Therapy
Authors: Gökçe Kağan , Doğan Demet , Yazıcı Merve
Published: May 2024

Objective: Anticoagulant therapy is commonly used in the treatment of cardiac and thromboembolic diseases, with bleeding being the most common side effect, which increases in likelihood with prolonged usage. Intestinal intramural hematoma, although rare, is a potential complication of anticoagulant therapy.
Case: Herein, we present the case of a 49-year-old male patient who presented to our outpatient general surgery clinic with complaints of nausea, vomiting, and abdominal pain. Upon examination, electrocardiography (ECG) revealed sinus rhythm without any ischemic changes, and echocardiography findings were within normal limits. The patient reported the use of warfarin, and his International Normalized Ratio (INR) was found to be 14.7 (normal range: 0.8-1.1). A 10 mg (1 ampoule) intravenous (IV) infusion of vitamin K was administered, and the warfarin dosage was adjusted accordingly. Subsequent follow-up assessments showed normalization of the INR levels.
Conclusion: Intestinal intramural hematoma is an exceedingly rare condition that necessitates prompt diagnosis and intervention, as delayed recognition can lead to life-threatening complications. Clinicians should maintain a high index of suspicion for intestinal obstruction secondary to anticoagulant therapy in patients presenting to the emergency department with symptoms such as abdominal pain, nausea, and vomiting.
Improving the Escalation of Micro, Small, and Medium Enterprises (MSME) Based on Digital Economy Acceleration and Capability Through Value Creation on West Java SME Enterpriser
Authors: Hermina Nurul
Published: May 2024

MSME acceleration in Indonesia has an essential role in enhancing the national economy and contributing significantly to Indonesia's GDP. However, in its implementation, there are still several obstacles, including limited connections to digital technology, digital skills, and management. This research investigates the influence of the digital economy and capabilities on business performance through value creation on West Java MSME business actors or enterprises. The research implemented quantitative methods through descriptive and verification analysis, with partial least squares-structural equation modeling (PLS-SEM) analysis techniques. The number of samples used was 127 respondents consisting of experts and practitioners (expert judgment). The sampling technique uses the online sampling method. The research results show that digital economic variables have a significant positive influence on MSME value creation, capability variables hold a direct positive influence on value creation, and also direct and indirect influences on MSME business performance. Value creation variables have a direct influence on business performance. The results of this research can be used to improve digital business in a way that is more appropriate for West Java MSME business actors.
Fed Fund Rate: A Dominant Factor of Fortfolio Flows in Southeast Asia
Authors: Marino Wilman San , Badriatin Tine , Bintang F.D.S. Ignatia
Published: May 2024

The impact of globalization on cross-country portfolio investment is the high flow of stocks and bonds with the primary goal of taking high yields from rising prices without aiming to own a company. Emerging markets have generally been net recipients of foreign capital in recent decades, including the countries in Southeast Asia consisting of Indonesia, the Philippines, Malaysia, Singapore, and Thailand. The Fed Fund Rate is believed to be the most influential factor in portfolio flows to various emerging market countries. This study will model portfolio equity flows to Southeast Asia over the last 20 years. Model testing uses the moderation analysis process model 4 by Andrew F. Hayes. The findings of this study indicate that the Fed Funds Rate has a greater effect on Southeast Asia's Equity Flows Portfolio than Internal Gross Domestic Product, which indicates the economic strength of a country in Southeast Asia.
FINANCIAL REPORTING EVOLUTION: A CASE STUDY OF IND AS IMPLEMENTATION OF INDIAN STEEL COMPANIES
Authors: Basavaraja Y N  , Dr. Veena. M
Published: May 2024

This article investigates the ramifications of the transition from Indian Generally Accepted Accounting Principles (IGAAP) to Indian Accounting Standards (Ind AS) on financial reporting within the Indian steel industry. In an era of global economic interconnectivity, the move towards aligning with international standards, notably International Financial Reporting Standards (IFRS), holds profound implications. The study underscores the paramount importance of transparency and comparability in financial reporting. The study employs the Grays Comparability Index (GCI) to quantitatively assess the conservatism levels in reporting various financial statement items. The findings reveal that while assets, liabilities, and equity exhibit relatively consistent reporting under both standards, Ind AS demonstrates a propensity for greater optimism in the reporting of income, expenses, and financial activities.
Análisis de factores de riesgo asociados al cáncer de próstata.
Authors: Rocha Soria. Mary Lenny
Published: May 2024

Introducción: El cáncer de próstata, común en hombres mayores, implica riesgos graves y requiere detección temprana. Su incidencia fluctúa, influenciada por pruebas de detección y avances médicos. Factores como la edad, dieta y antecedentes familiares aumentan el riesgo. Esta investigación se centra en evaluar estos riesgos en hombres mayores de 40 en Cochabamba durante 2023. Metodología: Se efectuó un estudio descriptivo y cuantitativo en hombres de Cochabamba, 40 años o más, evaluando factores de riesgo de cáncer de próstata. Se encuestaron 1464 hombres sobre edad, antecedentes familiares, dieta, peso, inflamación prostática y exposición a químicos. Se utilizó un formulario en línea y Excel para el análisis, cumpliendo con las normas éticas y el consentimiento informado. Resultados: Los resultados de la encuesta en hombres de Cochabamba revelan la prevalencia de factores de riesgo de cáncer de próstata en 1464 participantes. Se detalla la distribución por edad, antecedentes familiares, dieta, peso, historial de inflamación prostática, exposición a químicos y vasectomía. Se encontró una alta incidencia de antecedentes familiares (24,2 %) y prostatitis crónica (32,5 %), mientras que la exposición a químicos en el trabajo fue baja (7,8 %) y la vasectomía poco común (2,6 %). Discusión: El estudio reveló que el 24.2 % tenía antecedentes familiares de cáncer de próstata, destacando la influencia genética en el riesgo. La dieta alta en grasas afectó al 28.8 %, mientras que la prostatitis crónica se encontró en el 32.5 %. La exposición a químicos en el trabajo fue del 7.8 %, y la vasectomía se asoció con el 2.6 % de los participantes.
Uji Aktivitas Antibakteri Rebusan dan Infusa Daun Jeruju (Achantus illicifolious) terhadap Bakteri Methicilin Resistant Staphylococcus aureus (MRSA)
Authors: Maria Dewi Ni Putu , Cahyaningsih Erna , Arman Anita Dewi Ni Luh Kade , Surya Rahadi I Wayan , Sandhi Kusuma Yuda Putu Era , Santoso Puguh
Published: May 2024

Penyakit infeksi masih menjadi masalah kesehatan di seluruh dunia termasuk di Indonesia. Salah satu penyebab infeksi yang perlu diwaspadai adalah restensi terhadap bakteri Methicillin Resistant Staphylococcus aureus (MRSA). Penggunaaan antibiotik yang berkelanjutan dapat menimbulkan masalah resistensi mikroba. Indonesia memiliki berbagai spesies tanaman yang sebenarnya dapat memberikan manfaat namun belum dibudidayakan secara khusus. Daun jeruju (Achanthus illicifolius) dari tumbuhan golongan mangrove yang mempunyai senyawa bioaktif yang berpotensi sebagai bahan antibakterial. Tujuan dari penelitian ini Untuk mengetahui aktivitas antibakteri rebusan dan infusa daun jeruju terhadap bakteri MRSA. Pengujian aktivitas antibakteri menggunakan bakteri MRSA. Hasil skrining fitokimia infusa daun jeruju memiliki senyawa metabolit sekunder berupa flavonoid, tanin, saponin dan kuinon. Sedangkan hasil skrining fitokimia rebusan daun jeruju memiliki metabolit sekunder berupa tanin, saponin dan kuinon. Berdasarkan hasil penelitian yang dilakukan pada infusa dan rebusan daun jeruju pada konsentrasi 30%, 60% dan 90% tidak memiliki daya hambat terhadap aktivitas antibakteri MRSA, yang dilihat dari zona hambat. Zona hambat nol pada bakteri MRSA dapat disimpulkan bahwa infusa dan rebusan daun Jeruju (Achantus illicifolious) tidak memiliki aktivitas antibakteri terhadap bakteri MRSA
Potensi Kayu Manis sebagai Obat untuk Meredakan Nyeri Haid: Literature Review
Authors: Laksmi Puspa Sari Gusti Ayu Putu , Ari Kusuma Yana I Gusti Agung , Lilis Adnyani Ni Putu
Published: May 2024

Menurut World Health Organization (WHO) pada tahun 2015 melaporkan secara global rata-rata lebih dari 50% wanita mengalami nyeri haid. Tercatat kejadian nyeri haid atau dysmenorrhea di Indonesia sebesar 64,25% yang meliputi dysmenorrhea primer (54,89%) dan dysmenorrhea sekunder (9,36%). Nyeri haid merupakan gejala menstruasi yang umum terjadi pada wanita yang mengalami menstruasi. Kondisi ini ditandai dengan terjadinya kram dan kejang nyeri kolik pada perut bagian bawah yang berdampak terganggungnya aktivitas sehari-hari. Nyeri haid ini kemungkinan dikarenakan oleh kadar prostanoid yang berlebih atau tidak seimbang serta eicosanoid yang dilepaskan dari endometrium selama menstruasi
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Characteristics of brain lesions found using MRI imaging in patients with post-COVID with signs of cognitive decline
Authors: Kurakh Artur V. , Ahii Vladyslava I. , Chopey Ivan V. , Hechko Mykhailo M. , Chubirko Kseniya I.
Published: May 2024

Aim: To describe and evaluate abnormalities of the brain in post-COVID patients with neurologic symptoms and cognitive deficits using MRI imaging of the brain.
Materials and Methods: We included 21 patients with a previous positive PCR testing for SARS-CoV-2 and one or more of the following symptoms: memory and cognitive decline, dizziness, anxiety, depression, chronic headaches. All patients had MRI imaging done at onset of symptoms, but after at least 1 year after positive testing for COVID-19 based on the patient’s previous medical history.
Results: All of the patients complained of lack of concentration, forgetfulness, hard to process information. 15 patients suffered from confusion, 10 from anxiety. Of the 21 patients 14 had isolated chronic headaches, 3 had isolated dizziness, 4 patients had both symptoms upon inclusion. All patients underwent MRI imaging as a part of the diagnostic workup and had varying degrees of neurodegeneration. Conclusions: Our data correlates with existing research and shows tendency for cognitive decline in post-COVID patients. This provides groundwork for further research to determine correlation between acceleration of neurodegeneration and post-COVID.
Dynamics of indicators of functional state and physical development of students in the process of high-intensity interval training
Authors: Rebryna Anatolii A. , Rebryna Andrii A. , Kolomoiets Halyna A. , Antonets Vasyl F. , Flerchuk Viktor V. , Liakhova Nataliia , Kasich Natalia P.
Published: May 2024

Aim: To investigate the effect of high-intensity interval training (HIIT) based on the CrossFit system on the level of students’ functional state and physical development.
Materials and Methods: The research involved 36 male students who were engaged in HIIT during their studies. Indicators of students’ functional state and physical development after 1 and 3 years of HIIT were studied. The functional state was assessed by indicators of the cardiovascular and respiratory systems, and physical development – by physical education tests.
Results: It has been found that HIIT has a positive effect on the indicators of the functional state of the cardiovascular and respiratory systems of the body and the physical development of students. After three years of HIIT sessions, students significantly improved their heart rate, vital capacity of the lungs, Stange test, Genchi test, duration of recovery heart rate, as well as the level of development of speed qualities, strength qualities, endurance and flexibility.
Conclusions: It has been established that the sports-oriented form of organization of physical education training sessions with the use of HIIT based on the CrossFit system is quite effective in improving the indicators of the functional state and physical development of students. A high level of these indicators will help to improve students’ health, improve their well-being, and increase the effectiveness of their educational and, in the future, professional activities.
Pseudomembranous colitis as a complication in Covid-19
Authors: Filip Stepan S. , Slivka Rudolf M. , Bratasiuk Andrii M. , Skrypynets Yuriy P. , Shitev Anatoly I.
Published: May 2024

Aim: To improve the results of treatment of patients with pseudomembranous colitis against the background of coronavirus infection.
Materials and Methods: The study presents the results of a retrospective analysis of 96 patients with pseudomembranous colitis, who were treated in the infectious Covid department at the base of the Uzhhorod City Clinical Hospital since 2020 to 2022. The average age of patients was 55.2 years, there were 38 (39.5%) men and 58 (60.5%) women. Diagnosis of complications – pseudomembranous colitis (PMC) – was based on clinical data, ultrasound and CT of the abdominal organs, fibrocolonoscopy, laparoscopy.
Results: The frequency of PMC from the total number of patients who were in hospital treatment (8205 patients) due to COVID-19 was 1.17%, and this indicator was 0.62% in 2020, and 2.28% in 2021. Indications for operative treatment were: colon perforation – 9.4% of patients; peritonitis (diffuse, widespread) without obvious perforation of the colon wall – 85.5% of patients; mesenteric thrombosis – 4.1% of patients. In the case of perforation of the colon, resection of the colon was performed with the formation of a proximal colostomy and ileostomy. In case of mesenteric thrombosis, resection of the affected part of the small intestine was performed. In case of peritonitis without clear intraoperative detection of perforation of the colon wall, intraoperative lavage was performed.
Conclusions: 1) The frequency of detection of PMC in patients with COVID-19 in 2020 was 0.62%, and in 2021 - 2.28%. 2) The sensitivity of CT in the diagnosis of surgical complications of PMC was 72%, and the specificity was 58%. 3) Conservative treatment was effective in patients with PMC in 88.8% of cases, 21.2% had complications that required emergency surgical interventions. 4) The total mortality in patients with PMC was 11.36%, although this indicator was significantly higher in the event of surgical complications and operative treatment (22.4%).
Analysis and interpretation of Coronavirus infection children’s incidence, contributing factors, risks of complications and their relationship
Authors: Horlenko Olesya M. , Hechko Khrystyna , Prylypko Lyubomyra B. , Hechko Mykhaylo , Horlenko Fedir V. , Tomey Adrian I. , Lenchenko Agneta V.
Published: May 2024

Aim: To study and investigate the incidence of Coronavirus infection in children, the course of the disease, the risks of complications and their interrelationships
Materials and Methods: Study included the analysis and observation of children (n=55, aged 14.36}3.62 years) with confirmed Coronerovirus infection, who were observed in the CNE ≪CMCH≫ in Uzhgorod in outpatient conditions. A study of clinical presentations, a clinical and laboratory examination followed by a mathematical analysis of the symptoms data in children with an identified Coronavirus infection and in the dynamics up to week 30 (with survey intervals in 3 weeks) from the diagnosis verification was carried out
Results: A dynamic analysis of the clinical manifestation of symptoms in children with an identified Corona virus infection and within 30 weeks (with survey intervals of 3 weeks) from the beginning of the diagnosis verification was carried out. Complaints from the respiratory system were prevailed. The most long-lasting complaint was observed ≪changes in the sense of taste and smell≫ (from 35(63.6%) to 6(10.9%) up to 18 weeks inclusive. Other complaints ≪Cough, Rhinitis, Shortness of breath, Pain in the chest≫ was observed for 6 weeks. Sore throat, muscular and joint pain were persisted for 3 weeks. Fever was not identified at week 3. Illness with other viral respiratory diseases started at week 9 and was observed until week 30 (from 10(18.2%) to 19(34.5%)) with varying levels. A decrease in cases of IgM identification was observed within 6 weeks (from 55, 100% to 20, 36, 4%). On the 9th week, the presence of IgM was not established. There is also an increase in the number of cases of detection of IgG in patients with a level maximum of 6 weeks.
Conclusions: There is a positive effect of the CRP level on the occurrence of symptoms of cough, rhinitis, shortness of breath, chest pain, change in taste and smell, muscle and joint pain (r=0.33-0.55), with the most significant data for the symptom of pain in chest (p=0.00001). Ferritin level interactions mostly had a negative direction (r=-0.35-0.48, p=0.02-0.00001) on the development of symptoms, with the exception of rhinorrhea (r=0.48, p=0.00002) and chest pains (r=0.39, 0.003). According to multiple logistic regression analysis the chance of the symptom of a change in taste and smell increases due to an increasing in the level of Procalcitonin in 1.48 times. The chance of the symptom of shortness of breath increased due to an increasing in the Ferritin level in 1.025 times
Endoscopic and morphological features of chronic gastritis in patients with lumbar spine osteochondrosis
Authors: Filip Stepan S. , Kochmar Vitaliy M. , Stoika Vasyl V. , Pushkash Ivan I.
Published: May 2024

Aim: of the study is to determine the endoscopic and morphological features of chronic gastritis (CG) in patients with lumbar spinal OC.
Materials and Methods: 102 patients with lumbar spine OC and CG were examined. The patients were diagnosed with Helicobacter pylori (HP) infection, according to which the patients were divided into two groups: the first group included 92 HP-positive patients, the second group consisted of 10 HP-negative patients.
Results: Among HP infected patients with lumbar spine OC, erosive gastropathy was most often diagnosed (in 40 (43.5%) of the examined), as well as erosive-papular and erosive-hemorrhagic gastropathy (in 14 (15.2%) and in 16 (17, 4 %) of patients, respectively), while erythematous gastropathy was more often diagnosed among HP-negative patients (in 7 (70.0 %) cases, respectively).
Conclusions: 1. 90.2% of patients with lumbar spine OC and CG have been diagnosed with HP infection. 2. Endoscopically, the lesion of the stomach MM in patients with lumbar spine OC corresponds mainly to erosive and erosive-hemorrhagic forms of gastropathy. 3. During histological examination of stomach MM, mainly 2nd and 3rd degrees of inflammation were established, especially in patients with erosive, erosive-papular and erosive-hemorrhagic forms of gastropathy.
Evaluation of functional interaction masseter and sternocleidomastoid muscles affected by TMJ dysfunction
Authors: Vovk Victoria V. , Skibitskyi Vadym S.
Published: May 2024

Aim: To evaluate the functional connection and the bioelectrical state of the m.masseter and m. sternocleidomastoid using functional tests before and after treatment.
Materials and Methods: The sample consisted of 21 individuals with temporomandibular joint dysfunction. Examinations were carried out before and after treatment using repositioning splint therapy and in seated/standing positions.
Results: M. masseter - p=0.072 before treatment and p=0.821 after treatment. Symmetry is also maintained after treatment. After treatment, a significant difference is noted at the level of significance p<0.001 for the right chewing muscle. In seated and standing positions before treatment did not reveal a statistically significant difference (p=0.07, p=0.143) and after (p=0.272, p=0.623).M. sternocleidomastoid- p<0.001 when comparing right and left sides. After treatment, there was no difference between the right and left sides (p=0.169). No statistical difference was found when assessing indicators separately for the right and left muscles in seated and standing positions (p=0.304, p=0.611, p=0.089, p=0.869). When comparing the bioelectric potentials of the right muscle before, after treatment, a statistically significant difference was found p=0.001.
Conclusions: Biostatistical analysis of the indicators of bioelectrical activity of m. masseter and sternocleidomastoid indicates no changes in muscle microvolt indicators with changes in body position in patients. However, repositioning splint therapy is associated with reduced muscle tone in initially more spasmodic muscles. It is worth noting that the symmetry of interaction between muscles improves.
Dynamic indicators of acute respiratory diseases treatment in children after correction
Authors: Horlenko Olesya M. , Pikina Iryna Yu. , Prylypko Lyubomyra B. , Kossey Gabriella B. , Roshko Ihor H. , Brych Valeriya V. , Kedyk Antonina V.
Published: May 2024

Aim: To study the Respiratory pathology of the upper respiratory tract, markers of the inflammatory response of the organism, Oxidative stress, Metabolic adaptation and possibilities of correction.
Materials and Methods: The study group (n=111) included school-aged children (10-14 years old). The general group of inflammatory diseases of the respiratory tract (J000-J06) was considered, with a diagnosis of acute respiratory infection (ARI) of viral and bacterial origin and included local inflammationof the upper respiratory tract with presentation of acute pharyngitis (68.0%), acute bronchitis (22,0%), acute tonsillitis (10,0%).
Results: Dynamic observation of groups of children who received optimized (group 1, n=60) and basic (group 2, n=51) treatment was carried out. The level of the erythrocyte pool correlated with IL-1 (r=-0,29, p=0,03), IL-4 (r=0,32, p=0,01), TNF-α (r=-0,35 , p=0,006). Creatinine value correlated with IL-10 (r=0,3, p=0,005), γ-IFN (r=0,42, p=0,001), TNF-α (r=0,25, p=0,05). Correlations of ferritin presented positive correlation values with the level of total protein (r=0,26, p=0,04) and TNF-α (r=0,41, p=0,001).
Conclusions: After the optimized treatment, there was a significant decrease in the reliable levels of CRP and γ-IFN by 7 and 4,4 times (by groups) and 5,8 and 3,2 times (by groups), respectively. Correlation relationships of urea levels with IL-2,4 were detected. The level of the erythrocyte pool correlated with IL-1,4, TNF-α, Ferritin presented positive correlation values with the level of total protein,TNF-α .
Biliary atresia in children (analytical literature review and review of own observation)
Authors: Gorbatyuk Olga , Kurylo Halyna
Published: May 2024

Aim: to review information resources and analysis of the own experience on this problem for the provision of modern knowledge in the pathogenesis of the pathology, the latest diagnostic and treatment technologies, with consideration of the need to adhere to a single strategy in the management of patients with BA.
Materials and Methods: The analysis of the data regarding the results of existing studies evaluating the clinical benefit and safety of diagnostic and treatment methods in Biliary atresia.
Conclusions: BA is the leading cause of neonatal cholestasis development. Early diagnostics of BA, based on the complex evaluation of clinical-laboratory, instrumental and morphological signs of the pathology, has a significant meaning. Surgical correction during the first 2 months of life – the Kasai procedure, as well as dynamic post-surgery follow-up significantly prolong the life of children and allow postponing liver transplantation. The highest patient survival both at the first stage of treatment - conduction of the Kasai procedure and the stage of liver transplantation may be achieved by joined work of surgeons and pediatricians, which allows considering the whole row of possible problems.
Peculiarities of treatment of maxillofacial polytrauma during wartime
Authors: Korkishko Victor P. , Zhero Natalia I. , Jenča Andrej , Jenča Andrej , Petrašova Adriana , Jenčova Janka
Published: May 2024

Aim: Analyzing of the last-time papers in this subject in organizing, diagnostic and surgery tactic is the aim of this work.
Materials and Methods: The study analyzed the experience of treating patients with maxillofacial polytrauma before and after February 24, 2022. Research methods: bibliographic, systematic, comparative, general clinical, radiological and retrospective analysis.
Conclusions: Tactic of the multidisciplinal team should based on the principles of damage control, which involves the initial performance of manipulations and surgical interventions that ensure the patient’s survival. Modern strategies for infusion-transfusion therapy play a significant role in severe trauma cases. Choosing the rational management of this therapy for severe trauma remains an important issue. Reconstructive surgeries are recommended to be performer deferred, after surgical wound management, neurosurgical interventions and stabilization of the patient common status. Patients with maxillofacial polytrauma needs in specialized medical care at all the levels. Active wound management aimed at creating favorable conditions for healing, comprehensive medical treatment, prevention, early detection and timely treatment of complications.
A case of leptospirosis in transcarpathia complicated with Jarisch-Herxheimer reaction
Authors: Vysochanska Vlasta V. , Babych Myroslava S. , Kohutych Anton I. , Halamba Andriana A.
Published: May 2024

A case report of Jarisch-Herxheimer (JHR) reaction on a 10th day of Leptospirosis caused by Leptospira Pomona. JHR occurs as a complication of an antibiotic treatment of various spirochetes and may lead to respiratory distress syndrome, renal failure, hepatic insufficiency, and multiple organ failure. This case represents a skin and cardio-vascular form of JHR with no lung involvement. The patient was treated with benzylpenicillin and low dexamethasone doses for 5th day of the disease with a shift to ceftriaxone and high doses of methylprednisolone. The fastest diagnosis of a sporadic zoonotic disease, early start of antibiotic therapy, and adequate doses of corticosteroids are key to the successful treatment of leptospirosis.
Using Acupuncture to Manage Hot Flushes & night sweats in women taking tamoxifen for early breast cancer: two observational studies.
Authors:   , De Valois Beverley Ann
Published: May 2024

This research comprises two observatioal studies investigating the use of acupuncture to manage hot flushes and night sweats that are side effects of tamoxifen as an adjuvant treatment for early breast cancer. Two forms of acupuncture were examined: traditional body acupuncture and ear acupuncture.
Women's Experience of Breastfeeding in the Current Japanese Social Context: Learning from Women and their babies.
Authors:   , Hashimoto Naoko
Published: May 2024

This study is about Japanese women's experiences of breastfeeding in the current Japanese social context. The research was based on a Japanese way of knowing 'ZEN-JIN-TEKI"; the way of understanding a phenomenon as a whole. Adapting the principles of an emergent design in naturalistic enquiry, the research was undertaken in order to explore the nature of the topic in the field, and to develop an analytical framework that could be used for qualitative data collected in Japanese language. Three women were interviewed at 3-4 months in the postnatal period, and their emotions were identified as key to understanding breastfeeding from a woman's point of view.
FACTORS ASSOCIATED WITH HISTORY OF EXCLUSIVE BREASTFEEDING AT MAHDARINA PRATAMA CLINIC MEDAN SELAYANG DISTRICT OF MEDAN CITY
Authors: Safitri Mey Elisa , Us Hafsah
Published: May 2024

Breastfeeding is a special pride for a woman to her baby. According to data from the WHO in 2017 globally, less than 40% of infants fewer than 6 are exclusively breastfed and the rest have been given complementary foods. The impact that will occur for the mother is the risk of breast cancer, ovarian cancer, uterine cancer, porous bones, maternal diabetes, stress, and anxiety. While the impact on infants is gastrointestinal infections, respiratory infections, risk of allergies, risk of decreased intelligence, risk of obesity, risk of vascular disease, risk of diabetes, risk of cancer in children, risk of chronic disease. This study aimed to analyze factors associated with history of exclusive breastfeeding at Mahdarina Pratama Clinic, Medan Selayang District, Medan City. This was analytical survey research with a cross sectional design. The population was mothers who had babies aged 7-12 months who came to the Clinic totaling 53 people and all of them were used as research samples. The data used primary data and tested by Chi Square test.The results of this study indicated that the majority of knowledge factors were knowledgeable enough was 41.5%, negative attitudes was 54.7%, the majority of mothers work 50.9%. The results of the Chi-Square test found knowledge p = 0.024 <0.05, attitude p = 0.035 <0.05 and work p = 0.002 <0.05.The conclusion shows that there is a relationship between knowledge, attitudes and work with a history of exclusive breastfeeding at Mahdarina Pratama Clinic, Medan Selayang District, Medan City. It is ecpevted to nursing mothers to pay more attention to information about exclusive breastfeeding through print and social media, especially working mothers.
Keywords: knowledge; attitude; occupation; history of exclusive breastfeeding
ANALISIS FAKTOR-FAKTOR YANG MEMENGARUHI PELAYANAN KEBIDANAN DENGAN KEPUASAN PASIEN DI RUANG RAWAT INAP RSUD PANYABUNGAN TAHUN 2022
Authors: HARAHAP GUSLAINI PURNAMA INTAN PAN , Asriwati  , Nur’aini  , Wiwi Wardani Tanjung  , Eva Yusnita Nasution
Published: May 2024

Users of hospital services, namely patients, demand quality service. Patients will feel satisfied when they get quality service. Surveys conducted at Panyabungan Hospital, there were several problems found such as patients felt officers were not fast in providing action, lack of cleanliness of toilets in the room, officers sometimes not friendly to respond to patients, and officers sometimes incomplete providing information about patient complaints. This study aims to analyze the factors that affect midwifery services with patient satisfaction in the Inpatient Room of Panyabungan Hospital in 2022. The type of research used is analytical with a cross sectional design. The population in this study was all elective post-sectio inpatients at RSUD Panyabungan. The sample in this study amounted to 73 people, the sampling technique used purposive sampling techniques. Data were obtained through the results of interviews using questionnaires. The data analysis method was analyzed univariately, bivariately using the Chi-Square test at a 95% confidence level (P<0.05) and a multivariate test with multiple regression tests. The results showed that assurance, tangible, empathy, responsive variables were related to patient satisfaction at Panyabungan Hospital. The most dominant variable is assurance. It is recommended to RSUD Panyabungan to conduct periodic and continuous patient satisfaction surveys to evaluate the performance of health services and service quality at RSUD Panyabungan.
Study fenomenologi: Intervensi Sosial Untuk Mereduksi Stigma Terhadap WUS Dalam Memutus Mata Rantai Penularan Covid-19
Authors: Surbakti Elisabeth , Maida Pardosi  , Efendi Sianturi  , Rina Doriana Pasaribu  , Efbertias Sitorus
Published: May 2024

Social stigma can encourage people to hide their illness so that they are not discriminated against, prevent them from seeking medical assistance immediately, and prevent them from carrying out healthy lifestyle behaviors without realizing it will cause more transmission to others. The aim of the study was to carry out a phenomenological survey of social interventions to reduce the stigma against WUS in breaking the chain of transmission of Covid-19 in the working area of the Medan Helvetia Health Center. The target to be achieved from this research is the formation of cooperation in tackling the transmission of Covid-19 which involves all community leaders, especially WUS. The research was carried out in Helvetia District, the working area of the Helvetia Health Center, Medan City. The research method was carried out using a qualitative approach. The qualitative approach used is participatory action research. The research procedures to be carried out are engagement/intake, data collection and need assessment (phenomenological survey), model formulation, intervention and monitoring and evaluation and termination. Data collection methods were carried out by sharing, in-depth interviews, (FGD) and questionnaires. Interactive model analysis is used to analyze qualitative data on phenomenological surveys and the process of conducting participatory action research. The results of the research, the phenomenological survey generally closed oneself when exposed to Covid-19, did not tell neighbors, friends or family but after recovering they were told, with the aim of not being ostracized or avoided by the local community. The FGD was conducted to look at the problems found in the phenomenological survey, and the results of the discussion resulted in a social intervention, namely the training of the Covid-19 Task Force as counselees in reducing the stigma of Covid-19, carried out for 3 days. Implementation of participatory action research requires a long time to be able to see changes in behavior and social change, for this reason further research is needed to see the persistence of interventions carried out by the Covid-19 Task Force.
STATUS DEBRIS INDEX SEBELUM DAN SESUDAH DILAKUKAN DEMONSTRASI MENYIKAT GIGI DENGAN CARA ROLL TECHNIC PADA SISWA KELAS IV & V SEKOLAH DASAR KARTIKA XXI-5 MANADO
Authors: Ni Made Yuliana  , Jeineke E. Ratuela  , Jeana L. Maramis  , Yenny Lisbeth Siahaan
Published: May 2024

Demonstration of how to brush teeth is a teaching method by presenting lessons through direct demonstration of the object or showing a process or procedure. Roll Technique is the method most often recommended because it is simple but efficient and can be used throughout the mouth. Debris Index (DI) is a score (value) of soft deposits that occur due to food residue attached to the tooth surface. This study aims to determine the status of the debris index before and after a demonstration of brushing teeth using the roll technique. The type of research is experimental research with a One Group Pretest-Posttest design. The total population was 52 students and the total sample was 48 students, the time of the research was in May 2019 at Kartika XXI-5 Manado Elementary School. This research was to see the difference in debris index status before and after the demonstration method of brushing teeth using the roll technique using a paired sample t test. The results of this study showed that the average debris index before the demonstration of brushing teeth using the roll technique for 48 respondents was 2.31, while the average debris index after the demonstration of brushing teeth using the roll technique for 48 respondents was 1.48. The calculated t value is 10.335 with a sig of 0.000. because sig <0.05, it can be concluded that Ho is rejected and H1 is accepted, which means there is a difference in the status of the debris index before and after a demonstration of brushing teeth using the roll technique for students in class IV & V at Kartika XXI-5 Elementary School, Manado.
HUBUNGAN PENGETAHUAN IBU HAMIL TENTANG ANEMIA DENGAN KEJADIAN ANEMIA DI PUSKESMAS PORIAHA KABUPATEN TAPANULI TENGAH TAHUN 2020
Authors: Maria Magdalena Saragi
Published: May 2024

Counseling with Audio Visual Media is a very important means of information because it contains elements of sound and images, which in the process of absorbing material involves the senses of sight and hearing. Lack of knowledge of elementary school age children about oral health is influenced by the lack of information obtained, including in the form of counseling, especially Audio Visual Media. This type of research was descriptive survey method with the aim to find out the description of dental and oral health counseling by using audio-visual media on the knowledge of students of Class VIII-1 at SMP Mulia Pratama Private Medan, with a sample size of 30 people. Data collection was carried out by distributing questionnaires before and after counseling using audio visual media. The results obtained by the data that the level of knowledge of students about oral health before counseling the majority of poor criteria, amounting to 11 people (36.6%). Whereas after counseling, the level of knowledge of students increased to a majority of good criteria, amounting to 27 people (90%), and none of them had bad criteria. The conclusion of this study is an increase in student knowledge about oral health after counseling with audio-visual media and in line with the objectives of counseling. It is expected that schools will provide communication media to increase knowledge, especially dental and oral health for students.
HUBUNGAN PENGETAHUAN DAN SIKAP TERHADAP TINDAKAN HIGIENE SANITASI PENGOLAHAN MAKANAN JAJANAN PEDAGANG KAKI LIMA DI PERUMNAS SIMALINGKAR KECAMATAN MEDAN TUNTUNGAN KOTA MEDAN TAHUN 2023
Authors: Deli Syaputri
Published: May 2024

Street vendors' knowledge regarding food processing sanitation hygiene will determine their attitudes, and this will influence the vendors' actions when processing food. Sanitary hygiene in street food processing is a health effort by maintaining and protecting cleanliness. Personal hygiene in food processing can be achieved if an understanding of the importance of maintaining personal health and cleanliness is embedded within oneself. The aim of this research is to determine the relationship between knowledge and attitudes towards sanitary hygiene measures for processing street food snacks at Perumnas Simalingkar in 2023. This research is analytical with a cross sectional design, which means a study where the variables including effects are observed. The sample used in this research used total sampling. The total sample size is all 35 street food traders. The data was analyzed using the chi square test. Based on the results of the chi square test, there is a relationship between knowledge of food sanitation hygiene measures with a p value of 0.019, and there is a relationship between attitudes towards food sanitation hygiene measures with a p value of 0.019. The research conclusion is that there is a relationship between knowledge and action and there is a relationship between attitude and action. The advice that researchers can give is to take part in training and counseling on food sanitation hygiene in order to guarantee the quality of the food to be sold.
POLA SEBARAN DAN ANALISIS FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN DEMAM BERDARAH DENGUE
Authors: Tanjung Risnawati , Jernita Sinaga  , Helfi Nolia  , Devyana Sembiring  , Dea Hutagalung
Published: May 2024

Dengue hemorrhagic fever (DHF) is a disease that causes death, known for > 200 years, and has become a health problem in the world, especially in developing countries, including Indonesia. Deli Serdang Regency had the highest number of cases in North Sumatra Province in 2019 with 1,326 cases, in 2020 there were 974 cases, IR: 50.4. In 2021, the Regency/City ranked 14th out of 514 Regency/City in Indonesia for the highest number of dengue fever cases in 2021 with 803 cases, IR/morbidity rate: 34.63/100,000 population, CFR/death rate: 0.12%. It is possible to identify the location of the patient to the address of the individual's location, so as to obtain information regarding the distribution pattern of cases in each region using the Geographic Information System (GIS) and analysis of factors related to the incidence of dengue hemorrhagic fever.This type of research is analytical observation with a case control approach. The sample in this study was all people living permanently in the working area of ??the Tanjung Morawa Community Health Center, totaling 48 respondents, 24 cases and 24 controls. The sampling technique was carried out using Simple Random Sampling, data was analyzed using the Chi Square test. Based on the research results, it shows that the variables related to the incidence of dengue fever are knowledge (p-value = 0.00; OR = 0.06), attitude (p-value = 0.00; OR = 21), 3M PSN (Mosquito Nest Eradication) actions Plus (p-value=0.000; OR=17) and unrelated variables are occupation (p-value=0.029; OR=0.23) and age (p-value=0.081; OR=0.29). It is recommended that the community health center be better able to increase public understanding about the management and prevention of dengue fever.
HUBUNGAN IgG DAN IgM DENGUE TERHADAP JUMLAH TROMBOSIT PADA PASIEN DEMAM BERDARAH DENGUE DI RUMAH SAKIT PENDIDIKAN PROF.dr.CHAIRUDDIN PANUSUNAN LUBIS UNIVERSITAS SUMATERA UTARA
Authors: Ice Ratnalela Siregar  , Muhammad Iqbal
Published: May 2024

The immune responses that play a role in DHF cases are Immunoglobulin M (IgM) and Immunoglobulin G (IgG). In primary Dengue infection, IgM begins to form and is detected on the third to fifth day, whereas in secondary Dengue infection, IgG levels will increase and then remain in the human body with low titers for life. Thrombocytopenia occurs in DHF patients due to antigen-antibody reactions and activation of the complement system which causes deposition of IgM and IgG immune cells on the surface of platelet cells. This causes reticuloendothelial cells to destroy platelets so that DHF patients will experience thrombocytopenia. To find out the analysis of dengue IgG and IgM examination on the results of platelet counts in dengue hemorrhagic fever patients at Prof. Teaching Hospital. dr. Chairuddin Panusunan Lubis, University of North Sumatra. The research used is descriptive quantitative. The examination method used is Dengue IgG and IgM Dengue Rapid Test, Platelet Count Examination using a Hematology Analyzer. The number of respondents is 11 samples taken by total sampling technique. Based on the results of a study of Dengue IgG and IgM in Dengue Hemorrhagic Fever patients at Prof. Teaching Hospital. dr. Chairuddin Panusunan Lubis, University of North Sumatra who had IgG + and IgM levels - more, namely 10 (92%) patients, IgG - and IgM + as many as 1 (8%) patients. Based on the number of platelets obtained in Dengue Hemorrhagic Fever patients at Prof. Teaching Hospital. dr. Chairuddin Panusunan Lubisa, University of North Sumatra, which decreased by 9 patients, and there were some who had normal platelet counts of 2 patients. There is no relationship between Dengue IgG and IgM on platelet count in Dengue Hemorrhagic Fever patients.
IDENTIFIKASI KADAR ASAM FOLAT PADA IBU HAMIL DI WILAYAH KERJA SUKOREJO, BANYUPUTIH, SITUBONDO
Authors: Hasan Rahmawaty , I'anah Fauzah Cholashatul
Published: May 2024

Preeklampsia masih merupakan masalah dalam pelayanan obstetrik dan merupakan penyebab meningkatnya mortalitas dan morbiditas ibu hamil dan neonatal. Patogenesis preeklampsia tahap 1 dimulai dengan plasentasi abnormal diantaranya berhubungan dengan nutrisi. Pada ibu hamil dengan preeklampsia ditemukan kadar folat yang rendah.  Peningkatan satu unit kadar serum asam folat menurunkan risiko preeklampsia secara signifikan. Tujuan penelitian ini adalah menganalisis kadar asam folat pada ibu hamil dengan preeklampsia dan kehamilan normal di wilayah kerja Banyuputih, Situbondo. Metode penelitian yang digunakan adalah case control dengan pengambilan sampel berupa non propability sampling untuk mengetahui perbedaan kadar asam folat pada preeklampsia dan kehamilan normal di wilayah kerja Sukorejo Banyuputih Situbondo. Jenis instrumen penelitian yang digunakan dalam penelitian ini adalah lembar observasi yang berisi hasil pemeriksaan kadar asam folat. Hasil penelitian menunjukkan ibu hamil dengan usia yang tidak berisiko (<40 tahun) dalam kehamilan namun dengan pemeriksaan tekanan darah tinggi 84%. Analisis atau identifikasi kadar asam folat pada ibu hamil di wilayah kerja Sukorejo Banyuputih Situbondo menunjukkan kadar yang rendah, yaitu sebesar 24%. Hal tersebut selaras dengan adanya pemeriksaan bidan yang menunjukkan tidak melakukan suplementasi asam folat selama kehamilan. Suplemen asam folat adalah upaya penting dari layanan kesehatan reproduksi untuk mewujudkan kesehatan ibu hamil, menjamin pertumbuhan dan perkembangan janin, serta mencegah komplikasi klinis selama kehamilan.