bluuebunny/crossref_metadata_2025 huggingface dataset:
PEREGRINOS MIGRANTES BOLIVIANOS A LUJÁN. PAISAJES RELIGIOSOS E IDENTIDADES EN ESCENA
Authors: Flores Fabián Claudio , Giop Tomás Facundo
Published: June 2020

A El presente artículo analiza la peregrinación de la comunidad boliviana a la ciudad de Luján a partir de la relación entre espacialidad e identidad. Todos los primeros domingos del mes de agosto, y desde hace seis décadas, los migrantes bolivianos radicados en distintos sitios de la Argentina, peregrinan a la ciudad de Luján activando un escenario espacial que pone en escena las prácticas propias del colectivo migrante y que funciona además como cristalizadores de una identidad que fusiona lo étnico y lo religioso. La perspectiva teórico-metodológica elegida se posiciona en un abordaje cultural sumando al trabajo de campo, las entrevistas y las observaciones participantes, el uso de fuentes estadísticas, periodísticas y una relectura de la bibliografía producida al respecto.
The system, the virus and the law
Authors: Finch John
Published: June 2020

As the coronavirus (COVID-19) pandemic progresses, with no visible end in sight, healthcare practitioners may ask whether the measures taken by public health authorities in the UK are going in the right direction. Who is legally responsible? John Finch looks at the institutional framework in which practitioners work and at the place of legal liability in healthcare delivery and management
The efficacy of quarantine measures against coronavirus
Authors: Wall Alison
Published: June 2020

Alison Wall looks at the reasons behind many governments' decision to lock down their countries
Singing for lung health for children with asthma
Authors: Henry Heather
Published: June 2020

Heather Henry explains the physical and mental health benefits of vocal exercises for young people
Coexistence of bright and dark cavity solitons in microresonators with zero, normal, and anomalous group-velocity dispersion: a switching wave approach
Authors: Talla Mbé Jimmi Hervé , Chembo Yanne K.
Published: June 2020

We propose a theoretical study to analyze how both dark and bright Kerr solitons can be generated in whispering-gallery mode resonators with various regimes of the group-velocity dispersion, namely normal, anomalous, and null. The coexistence of these solitonic structures in each regime is shown to appear around a critical value of the laser pump. We also evidence that these solitons build up owing to a mechanism related to oscillation locking of switching waves, which connect the upper and the lower homogenous steady states.
Home is where the kitchen is: Rinco’s Restaurant (2009) and Little Forest (2014, 2018)1
Authors: Choi Jinhee
Published: June 2020

The kitchen has become a prominent trope in East Asian cinema, the narratives of which revolve around the homecoming of female protagonists: Rinco’s Restaurant (2009) and Little Forest (2014, 2018). In part due to the fact that the films are adaptations of different media – novel and manga, respectively – and in part motivated by their narrative and style – the female protagonist’s loss of voice in Rinco’s Restaurant and the less frequent recourse to the verbal to express taste in these works – the audience is challenged to imagine the taste of, and pleasure in consuming, food, conveyed through only a limited set of sensorial modes. I focus on the transformative aspect of divergent modes of media storytelling in these films and their original source texts, and further argue that the kitchen becomes a ‘choric’ space for female protagonists where the relationship between mother and daughter is reconfigured in order to reinvent themselves.
Transmedia Sai-lou: The evolution of Hong Kong’s core values through comics, film and street protests
Authors: Wong Wendy Siuyi
Published: June 2020

In this article, I investigate the evolution of the core values of the Hong Kong people through the term Sai-lou 細路, by means of storytelling in a transmedia context and with a focus on different historical stages, from approximately the end of the Second World War to the 2014 Umbrella Movement. Using the late 1930s four-panel comic strip, Sai-lou Cheung 細路祥 (Kiddy Cheung) created by Yuan Bou-wan 袁步雲 (1922–95) as the origin work for the term, this study examines the core values reflected in the 1950s film Sai-lou Cheung細路祥 (The Kid or My Son A-Chang) starring 9-year-old Bruce Lee, the 1999 film Sai-lou Cheung 細路祥 (Little Cheung) directed by Fruit Chan as well as news reports of the 2014 sit-in street protests whose student leaders the public regarded as Sai-lou 細路 (‘kids’).
Pintzelak, loreak eta paisaiak. Emakumeentzako heziketa artistikoa Euskal Herrian
Authors: Lekuona Mariskal Ane
Published: June 2020

XX. mendean zehar Euskal Herrian emakumeek jasotako heziketa artistikoa aztertuko da testu honetan. Alde batetik, arte plastikan interesa zuten neskek formakuntza lortzeko zituzten aukerak baita izan ziren joera desberdinak berrikusiko dira. Bestetik, emakumezkoen generoarekin lotura zuten heziketa baldintza bereziak, artista hauen produkzioan baita bizimoduan nolako eragina izan zuten identifikatzen saiatuko da. Azkenik, denboran aurrera gaiaren inguruan eman diren aldaketen hausnarketekin amaituko da azterketa.
Congestive heart failure in cattle; etiology, clinical, and ultrasonographic findings in 67 cases
Authors: Abd El Raouf Mustafa , Elgioushy Magdy , Ezzeldein Shimaa A.
Published: June 2020

Background and Aim: Congestive heart failure (CHF) is a clinical disorder that results from cardiac dysfunction with subsequent fatal outcomes in most cases. Several diseases are incriminated in occurrence of CHF. Therefore, the aims of this study were to identify CHF etiology and associated clinical findings in 67 cows and to investigate the relationship between CHF and the other body organs using ultrasonographic examination.

Materials and Methods: Sixty-seven cows affected by CHF admitted to the clinic with a history of loss of appetite, decrease in milk production, constipation, and brisket edema were thoroughly investigated clinically and ultrasonographically. In addition, ten apparently healthy cows were used as a control group.

Results: Clinically, cows with CHF manifested jugular engorgement and pulsation (88.1%), brisket and/or intermandibular edema (77.6%), and muffled heart sounds (76.1%). Based on the ultrasonographic examination, traumatic pericarditis (82.1%) was the most prevalent etiology of CHF. Extracardiac etiology of CHF identified were exudative pleurisy (10.4%) and mediastinal abscesses (7.5%). Hepatomegaly (88.1%) and pleural effusion (61.2%) were the most documented consequences.

Conclusion: Both cardiac and extracardiac diseases could be associated with CHF in cattle. Ultrasonographic changes in liver and pleura secondary to CHF were the most common findings. Ultrasonography is a good tool for the diagnosis of cardiac and extracardiac etiologies of CHF in cattle.
Accurate Nonendoscopic Detection of Barrett's Esophagus by Methylated DNA Markers: A Multisite Case Control Study
Authors: Iyer Prasad G. , Taylor William R. , Johnson Michele L. , Lansing Ramona L. , Maixner Kristyn A. , Hemminger Lois L. , Cayer Frances K. , Yab Tracy C. , Devens Mary E. , Slettedahl Seth W. , Broderick Brendan T. , Mahoney Douglas W. , McGlinch Maria C. , Berger Calise K. , Foote Patrick H. , Giakomopoulos Maria , Allawi Hatim , Smyrk Thomas C. , Wang Kenneth K. , Katzka David A. , Wolfsen Herbert C. , Burke James A. , Ahlquist David A. , Kisiel John B.
Published: June 2020

INTRODUCTION:

Nonendoscopic Barrett's esophagus (BE) screening may help improve esophageal adenocarcinoma outcomes. We previously demonstrated promising accuracy of methylated DNA markers (MDMs) for the nonendoscopic diagnosis of BE using samples obtained from a capsule sponge-on-string (SOS) device. We aimed to assess the accuracy of these MDMs in an independent cohort using a commercial grade assay.

METHODS:

BE cases had ≥ 1 cm of circumferential BE with intestinal metaplasia; controls had no endoscopic evidence of BE. The SOS device was withdrawn 8 minutes after swallowing, followed by endoscopy (the criterion standard). Highest performing MDMs from a previous study were blindly assessed on extracted bisulfite-converted DNA by target enrichment long-probe quantitative amplified signal (TELQAS) assays. Optimal MDM combinations were selected and analyzed using random forest modeling with in silico cross-validation.

RESULTS:

Of 295 patients consented, 268 (91%) swallowed the SOS device; 112 cases and 89 controls met the pre-established inclusion criteria. The median BE length was 6 cm (interquartile range 4–9), and 50% had no dysplasia. The cross-validated sensitivity and specificity of a 5 MDM random forest model were 92% (95% confidence interval 85%–96%) and 94% (95% confidence interval 87%–98%), respectively. Model performance was not affected by age, gender, or smoking history but was influenced by the BE segment length. SOS administration was well tolerated (median [interquartile range] tolerability 2 [0, 4] on 10 scale grading), and 95% preferred SOS over endoscopy.

DISCUSSION:

Using a minimally invasive molecular approach, MDMs assayed from SOS samples show promise as a safe and accurate nonendoscopic test for BE prediction.
Association of Digestive Symptoms and Hospitalization in Patients With SARS-CoV-2 Infection
Authors: Cholankeril George , Podboy Alexander , Aivaliotis Vasiliki Irene , Pham Edward A. , Spencer Sean P. , Kim Donghee , Ahmed Aijaz
Published: June 2020

INTRODUCTION:

High rates of concurrent gastrointestinal manifestations have been noted in patients with corona virus disease 2019 (COVID-19); however, the association between these digestive manifestations and need for hospitalization has not been established.

METHODS:

This is a retrospective review of consecutive patients diagnosed with COVID-19. A total of 207 patients were identified; 34.5% of patients noted concurrent gastrointestinal symptoms, with 90% of gastrointestinal symptoms being mild.

RESULTS:

In a multivariate regression model controlled for demographics and disease severity, an increased risk of hospitalization was noted in patients with any digestive symptom (adjusted odds ratio 4.84, 95% confidence interval: 1.68–13.94).

DISCUSSION:

The presence of digestive symptoms in COVID-19 is associated with a need for hospitalization.
ASPECTOS RELACIONADOS À OFERTA DE COLOSTRO NA IMUNIDADE E SAÚDE DE BEZERRAS LEITEIRAS
Authors: Weiller Maria Amélia Agnes , Rohrig Rabassa Viviane , Nunes Correa Márcio , Burkert Del Pino Francisco Augusto
Published: June 2020

A criação de bezerras é ponto crucial para o bom desempenho de uma propriedade leiteira. Para garantir o sucesso da criação, o fornecimento de um colostro de qualidade tem papel central neste processo. Isso ocorre porque o tipo de placentação dos bovinos não permite a transferência de imunoglobulinas da mãe para o feto durante a gestação, associado ao fato de que, ao nascimento, estes animais ainda não têm seu sistema imune totalmente desenvolvido, sendo desta forma, dependentes das imunoglobulinas provenientes do colostro. Esta revisão tem o objetivo de trazer informações importantes relacionadas a imunidade de bezerras leiteiras, e que tem impacto direto na criação destes animais. Assim, será discutido brevemente como ocorre o reconhecimento de células invasoras pelo sistema imune, o desenvolvimento da imunidade em neonatos bovinos, a importância do fornecimento do colostro para a saúde dos bezerros e fatores relacionados à qualidade do colostro bovino. Por fim, abordaremos as diferentes maneiras possíveis de avaliar este colostro, destacando em seguida os impactos de uma má colostragem sobre o desempenho e saúde animal.
OBESIDADE: COMPREENDENDO ESSE DESEQUILÍBRIO ORGÂNICO EM CÃES E GATOS
Authors: Andrade Junior Antônio Gonçalves , Capella Sabrina Oliveira , Piñeiro Martha Bravo Cruz , Nobre Márcia Oliveira
Published: June 2020

A obesidade é uma condição patológica caracterizada pelo acúmulo excessivo de gordura, sendo uma das principais patologias observadas em cães e gatos. É uma doença de prevalência crescente e influenciada por diversos fatores genéticos e ambientais, tais como: raça, idade, sexo, status gonadal, endocrinopatias, dieta e atividade física. É uma condição patológica que predispõe o animal a diversas complicações na saúde, como redução da longevidade, problemas em articulações, neoplasias e diabetes mellitus. Existem diversos métodos que auxiliam no diagnóstico dessa patologia e que são importantes para o tratamento. Diante disso, esta revisão tem por objetivo expor e discutir as possíveis etiologias e complicações, os métodos utilizados para o diagnóstico da obesidade e tratamento.
Characterization of a Knock-In Mouse Line Expressing a Fusion Protein of κ Opioid Receptor Conjugated with tdTomato: 3-Dimensional Brain Imaging via CLARITY
Authors: Chen Chongguang , Willhouse Alex H. , Huang Peng , Ko Nora , Wang Yujun , Xu Bin , Huang Lan Hsuan Melody , Kieffer Brigitte , Barbe Mary F. , Liu-Chen Lee-Yuan
Published: June 2020

Activation of κ opioid receptor (KOR) produces analgesia, antipruritic effect, sedation and dysphoria. To characterize neuroanatomy of KOR at high resolutions and circumvent issues of specificity of KOR antibodies, we generated a knock-in mouse line expressing KOR fused at the C terminus with the fluorescent protein tdTomato (KtdT). The selective KOR agonist U50,488H caused anti-scratch effect and hypolocomotion, indicating intact KOR neuronal circuitries. Clearing of brains with CLARITY revealed three-dimensional (3-D) images of distribution of KOR, and any G-protein-coupled receptors, for the first time. 3-D brain images of KtdT and immunohistochemistry (IHC) on brain sections with antibodies against tdTomato show similar distribution to that of autoradiography of [3H]U69,593 binding to KOR in wild-type mice. KtdT was observed in regions involved in reward and aversion, pain modulation, and neuroendocrine regulation. KOR is present in several areas with unknown roles, including the claustrum (CLA), dorsal endopiriform nucleus, paraventricular nucleus of the thalamus (PVT), lateral habenula (LHb), and substantia nigra pars reticulata (SNr), which are discussed. Prominent KtdT-containing fibers were observed to project from caudate putamen (CP) and nucleus accumbens (ACB) to substantia innominata (SI) and SNr. Double IHC revealed co-localization of KtdT with tyrosine hydroxylase (TH) in brain regions, including CP, ACB, and ventral tegmental area (VTA). KOR was visualized at the cellular level, such as co-localization with TH and agonist-induced KOR translocation into intracellular space in some VTA neurons. These mice thus represent a powerful and heretofore unparalleled tool for neuroanatomy of KOR at both the 3-D and cellular levels.
Metabolic syndrome detection with biomarkers in childhood cancer survivors
Authors: Pluimakers V G , van Waas M , Looman C W N , de Maat M P , de Jonge R , Delhanty P , Huisman M , Mattace-Raso F U S , van den Heuvel-Eibrink M M , Neggers S J C M M
Published: June 2020

Purpose:

Augmented survival of childhood nephroblastoma and neuroblastoma has increased long-term side effects such as metabolic syndrome (MetS). Risk stratification is difficult after abdominal radiation because waist circumference underestimates adiposity. We aimed to develop a strategy for determining MetS in irradiated survivors using an integrated biomarker profile and vascular ultrasonography.

Methods:

The NCEP-ATPIII MetS-components, 14 additional serum biomarkers and 9 vascular measurements were assessed in a single-centre cohort of childhood nephroblastoma (n = 67) and neuroblastoma (n = 36) survivors and controls (n = 61). Multivariable regression models were used to study treatment effects. Principal component analysis (PCA) was used to study all biomarkers in a combined analysis, to identify patterns and correlations.

Results:

After 27.5 years of follow-up, MetS occurred more often in survivors (14%) than controls (3%). Abdominal radiotherapy and nephrectomy, to a lesser extent, were associated with MetS and separate components and with several biomarker abnormalities. PCA of biomarkers revealed a pattern on PC1 from favourable lipid markers (HDL-cholesterol, adiponectin) towards unfavourable markers (triglycerides, LDL-cholesterol, apoB, uric acid). Abdominal radiotherapy was associated with the unfavourable biomarker profile (β = 1.45, P = 0.001). Vascular measurements were not of added diagnostic value.

Conclusions:

Long-term childhood nephro- and neuroblastoma survivors frequently develop MetS. Additional assessment of biomarkers identified in PCA – adiponectin, LDL, apoB, and uric acid – may be used especially in abdominally irradiated survivors, to classify MetS as alternative for waist circumference. Vascular ultrasonography was not of added value.
Vitamin D and PTH: data from a cross-sectional study in an equatorial population
Authors: Neves Marques de Queiroz Natércia , Trindade Cunha de Melo Franciane , de Souza Resende Fabrício , Corrêa Janaú Luísa , Jorge Kzan de Souza Neto Norberto , Nascimento de Lemos Manuela , Lobato Virgolino Ana Carolina , Neres Iunes de Oliveira Maria Clara , Leite de Alcântara Angélica , Vilhena de Moraes Lorena , Franco David Tiago , Maia da Silva Wanderson , Souza Reis Scarlatt , Costa dos Santos Márcia , Contente Braga de Souza Ana Carolina , Freire Piani Pedro Paulo , Arroyo Lara Mourão Neyla , Mileo Felício Karem , Felício Abrahão Neto João , Felício João Soares
Published: June 2020

Objective:

Investigate the prevalence of vitamin D deficiency in an equatorial population through a large-sample study.

Methods:

Cross-sectional study with 30,224 healthy individuals from the North Region, in Brazil (Amazônia – state of Pará), who had 25-hydroxy-vitamin D (25(OH)D) and intact parathyroid hormone (PTH) serum levels measured by immunoassay method. Those with history of acute or chronic diseases were excluded. Abnormal levels of calcium, creatinine, glycemia and albumin were also exclusion criteria.

Results:

25(OH)D levels were 29.1 ± 8.2 ng/mL and values <12.7 ng/mL were equal to < −2 s.d. below average. Hypovitaminosis D was present in 10% of subjects according to the Institute of Medicine (values <20 ng/mL) and in 59%, in consonance with Endocrine Society (values 20–30 ng/mL as insufficiency and <20 ng/mL as deficiency) criteria. Individuals were divided according to four age brackets: children, adolescents, adults and elderly, and their 25(OH)D levels were: 33 ± 9; 28.5 ± 7.4; 28.3 ± 7.7; 29.3 ± 8.5 ng/mL, respectively. All groups differed in 25(OH)D, except adolescents vs adults. Regression model showed BMI, sex, living zone (urban or rural) and age as independent variables to 25(OH)D levels. Comparing subjects with vitamin D deficiency (<20 ng/mL) to those with vitamin D insufficiency (20–30 ng/mL), a difference between PTH levels in these two groups was observed (95.9 ± 24.7 pg/mL vs 44.2 ± 64.5 pg/mL; P < 0.01). Additionally, the most accurate predictive vitamin D level for subclinical hyperparathyroidism in ROC curve was 26 ng/mL.

Conclusion:

Our equatorial population showed low prevalence of vitamin D hypovitaminosis ranging with age bracket. The insufficient category by Endocrine Society was corroborated by our PTH data.
Circulating plasma proteins and new-onset diabetes in a population-based study: proteomic and genomic insights from the STANISLAS cohort
Authors: Ferreira João Pedro , Lamiral Zohra , Xhaard Constance , Duarte Kévin , Bresso Emmanuel , Devignes Marie-Dominique , Le Floch Edith , Roulland Claire Dandine , Deleuze Jean-François , Wagner Sandra , Guerci Bruno , Girerd Nicolas , Zannad Faiez , Boivin Jean-Marc , Rossignol Patrick
Published: June 2020

Objective:

Determining the factors associated with new-onset pre-diabetes and type 2 diabetes mellitus (T2D) is important for improving the current prevention strategies and for a better understanding of the disease.

Design:

To study the factors (clinical, circulating protein and genetic) associated with new onset pre-diabetes and T2D in an initially healthy (without diabetes) populational familial cohort with a long follow-up (STANISLAS cohort).

Methods:

A total of 1506 participants attended both the visit 1 and visit 4, separated by ≈20 years. Over 400 proteins, GWAS and genetic associations were studied using models adjusted for potential confounders. Both prospective (V1 to V4) and cross-sectional (V4) analyses were performed.

Results:

People who developed pre-diabetes (n = 555) and/or T2D (n = 73) were older, had higher BMI, blood pressure, glucose, LDL cholesterol, and lower eGFR. After multivariable selection, PAPP-A (pappalysin-1) was the only circulating protein associated with the onset of both pre-diabetes and T2D with associations persisting at visit 4 (i.e. ≈20 years later). FGF-21 (fibroblast growth factor 21) was a strong prognosticator for incident T2D in the longitudinal analysis, but not in the cross-sectional analysis. The heritability of the circulating PAPP-A was estimated at 44%. In GWAS analysis, the SNP rs634737 was associated with PAPP-A both at V1 and V4. External replication also showed lower levels of PAPP-A in patients with T2D.

Conclusions:

The risk of developing pre-diabetes and T2D increases with age and with features of the metabolic syndrome. Circulating PAPP-A, which has an important genetic component, was associated with both the development and presence of pre-diabetes and T2D.
CDC42 drives RHOA activity and actin polymerization during capacitation
Authors: Reyes-Miguel Tania , Roa-Espitia Ana L , Baltiérrez-Hoyos Rafael , Hernández-González Enrique O
Published: June 2020

Mammalian sperm cells acquire fertilizing capacity as a result of a process termed capacitation. Actin polymerization is important for capacitation; inhibiting actin polymerization prevents the adhesion and fusion of the sperm with the ovule. The main function of RHO proteins CDC42 and RHOA is to direct actin polymerization. Although these two RHO proteins are present in mammalian sperm, little is known about their role in capacitation, the acrosome reaction, and the way in which they direct actin polymerization. The purpose of this study was to determine the participation of CDC42 and RHOA in capacitation and the acrosome reaction and their relationship with actin polymerization using guinea pig sperm. Our results show that the inhibition of CDC42 and RHOA alters the kinetics of actin polymerization, capacitation, and the acrosome reaction in different ways. Our results also show that the initiation of actin polymerization and RHOA activation depend on the activation of CDC42 and that RHOA starts its activity and effect on actin polymerization when CDC42 reaches its maximum activity. Given that the inhibition of ROCK1 failed to prevent the acrosomal reaction, the participation of RHOA in capacitation and the acrosomal reaction is independent of its kinase 1 (ROCK1). In general, our results indicate that CDC42 and RHOA have different roles in capacitation and acrosomal reaction processes and that CDC42 plays a preeminent role.
Effect of nerve growth factor on the proliferation in newborn bovine testicular Sertoli cells
Authors: Niu Qiaoge , Cao Maosheng , Yuan Chenfeng , Huang Yuwen , Zhao Zijiao , Zhang Boqi , Wang Xin , Wei Yameng , Fan Wenjing , Zhou Xu , Li Chunjin
Published: June 2020

Nerve growth factor (NGF) has been proved to play important roles in male reproductive physiology, but the molecular mechanisms of NGF action remain unclear. In this study, the effects of NGF on the growth of newborn bovine testicular Sertoli (NBS) cells and the related signaling pathways were investigated. The NBS cells were treated in vitro with NGF (100 ng/mL) for 18 h. The expression levels of cell proliferation related genes, INHBB, and cytoplasmic specialization related gene were determined using real-time PCR and Western blot. The roles of PI3K/AKT and MAPK/ERK pathways in NGF-induced cell proliferation were investigated. It was found that NGF regulates proliferation and function of NBS cells via its receptor NTRK1 by activating the PI3K/ATK and MAPK/ERK signaling pathways. The study will help to further understand the role of NGF in male reproduction and provide new therapeutic targets for reproductive dysfunctions in male animals.
Lavado de activos y corrupción: análisis desde la perspectiva preventiva como medio para fortalecer la democracia
Authors: De la Torre Lascano Mauricio
Published: June 2020

Este trabajo tiene como principal finalidad el análisis de los sistemas para abordar el problema social que genera en los sistemas democráticos el delito de lavado de activos y la corrupción, ya que debilitan las estructuras del Estado. Este estudio inicia con el análisis de doctrina internacional y estudios académicos realizados, tomando en consideración la disyuntiva en adoptar el sistema represivo o preventivo, analizándolos individualmente para identificar cuál sería el más conveniente para fortalecer la democracia en las naciones, considerando que la relación existente entre las medidas de orden preventivo y represivo es inmanente y este flagelo no concluye con la mera represión punitiva, incrementando las penas y sanciones, pero tampoco con un sistema permisivo o laxo. Llegando a determinar como una opción válida la adopción del sistema preventivo en torno a un delito que cada vez se innova con nuevas estratagemas, por lo que se requiere estudios constantes debido a esa especificidad de características particulares que requieren ser analizadas permanentemente.
Impactos normativos y mediáticos de los casos de agresiones con ácido a mujeres en España y Colombia 2010-2017
Authors: Giraldo Duque Sheila
Published: June 2020

El presente documento expone los resultados de la investigación: “Estudio comparado de los impactos normativos y mediáticos de las agresiones con ácidos a mujeres sobrevivientes en España y Colombia”, la cual tuvo por objeto abordar la situación de estas agresiones con el propósito de responder a la pregunta sobre cómo ha sido el tratamiento noticioso de la temática en los dos países y su influencia en la estructuración y fortalecimiento de sistemas jurídicos. De esta manera, a partir de la implementación de una metodología de investigación cualitativa, se adelantó una revisión normativa y documental que permitió la selección de dos casos paradigmáticos, en los dos países, a partir de los cuales fue posible identificar impactos de la esfera mediática en escenarios de la vida y agenda pública, como: la influencia positiva de las prácticas comunicativas en el desarrollo normativo y jurisprudencial de los Estados, su incidencia en las decisiones judiciales, la regulación de la comercialización de sustancias químicas y la visibilidad de las organizaciones civiles que, lideradas en su mayoría por sobrevivientes, buscan la garantía de sus derechos. Finalmente, este trabajo presenta unas conclusiones en las que resalta la importancia del reconocimiento de la influencia de la esfera mediática en el tratamiento de las agresiones con ácidos en escenarios que resultan en la revictimización de esta población, víctima de una problemática que actualmente trasciende fronteras y el género femenino.
Potestad reguladora de las instituciones educativas y manuales de convivencia en la jurisprudencia de la Corte Constitucional: lineamientos en materia de convivencia escolar
Authors: Argüello Rueda José Darío , Patiño Zambrano Yuly Katherin
Published: June 2020

Este artículo forma parte de los resultados de la investigación titulada Dinámicas sociales y derechos fundamentales en las instituciones educativas de seis colegios del área metropolitana, dentro de la cual se confrontaron los manuales de convivencia de las instituciones objeto de estudio con la jurisprudencia constitucional, referida a los alcances y limitaciones con que cuentan los centros educativos al momento de ejercer su potestad reguladora.
Purebred and Crossbred Genomic Evaluation and Mate Allocation Strategies To Exploit Dominance in Pig Crossbreeding Schemes
Authors: González-Diéguez David , Tusell Llibertat , Bouquet Alban , Legarra Andres , Vitezica Zulma G
Published: June 2020

We investigated the effectiveness of mate allocation strategies accounting for non-additive genetic effects to improve crossbred performance in a two-way crossbreeding scheme. We did this by computer simulation of 10 generations of evaluation and selection. QTL effects were simulated as correlated across purebreds and crossbreds, and (positive) heterosis was simulated as directional dominance. The purebred-crossbred correlation was 0.30 or 0.68 depending on the genetic variance component used. Dominance and additive marker effects were estimated simultaneously for purebreds and crossbreds by multiple trait genomic BLUP. Four scenarios that differ in the sources of information (only purebred data, or purebred and crossbred data) and mate allocation strategies (mating at random, minimizing expected future inbreeding, or maximizing the expected total genetic value of crossbred animals) were evaluated under different cases of genetic variance components. Selecting purebred animals for purebred performance yielded a response of 0.2 genetic standard deviations of the trait “crossbred performance” per generation, whereas selecting purebred animals for crossbred performance doubled the genetic response. Mate allocation strategy to maximize the expected total genetic value of crossbred descendants resulted in a slight increase (0.8%, 4% and 0.5% depending on the genetic variance components) of the crossbred performance. Purebred populations increased homozygosity, but the heterozygosity of the crossbreds remained constant. When purebred-crossbred genetic correlation is low, selecting purebred animals for crossbred performance using crossbred information is a more efficient strategy to exploit heterosis and increase performance at the crossbred commercial level, whereas mate allocation did not improve crossbred performance.
Democracia y Justicia Social en las Escuelas: Dimensiones para Pensar y Mejorar la Práctica Educativa
Authors: Belavi Guillermina , Murillo F. Javier
Published: June 2020

La democracia y la justicia social se implican mutuamente. Esta afirmación, válida para la sociedad en general, lo es también para las escuelas. Con las ideas sobre Justicia Social de Nancy Fraser como marco, este artículo propone cinco dimensiones para avanzar en la Justicia Social y en la Democracia en las escuelas. En primer lugar, Redistribución de oportunidades y beneficios de la educación, como forma de romper el círculo perverso de la desigualdad desde la escuela; Reconocimiento de valores culturales y diversidad social, como segunda dimensión a través de la cual se cuestionan los valores culturales dominantes en la educación y se fomenta el respeto y el aprendizaje de las distintas identidades, perspectivas y estilos de vida de los miembros de la comunidad educativa. La tercera dimensión hace referencia a la Gobernanza escolar, gobernanza basada en la distribución de responsabilidades, la proactividad y la cooperación en redes plurales. La cuarta dimensión es Currículum crítico y participativo y la quinta y última, Cultura escolar democrática. Estas dimensiones invitan a identificar los conceptos abstractos en la forma concreta en que se realizan en las escuelas y, a partir de allí, reflexionar sobre ellos y sugerir prácticas que nos ayuden a mejorarlas.
Keputusan Mahkamah Konstitusi No. 97/2017 dan Pengaruhnya Terhadap Perubahan Identitas Perempuan Penghayat
Authors: Farihah Rindang
Published: June 2020

Sejak diberlakukannya PenPres No 1 tahun 1965 tentang Pencegahan Penyalahgunaan dan atau Penodaan Agama, aliran – aliran kepercayaan di Indonesia dianggap bukan bagian dari agama- agama yang diakui di Indonesia. Meski sebelumnya keberadaan mereka telah menjadi polemik dan perdebatan namun dikarenakan kebijakan tersebut telah membuat penganut aliran kepercayaan mengalami banyak diskriminasi dan stigmatisasi di masyarakat serta membawa pengaruh pada kehidupan ekonomi sosial politik serta nasib anak-anak mereka. Nasib bisa saja berubah dikarenakan kebijakan baru diakhir tahun 2017 melalui keputusan Mahkamah Konstitusi No 97 tahun 2017 tentang diperbolehkannya mengubah ‘agama’ menjadi ‘kepercayaan’ pada kolom agama yang tertera di KTP dan KK. Adakah niat mengubah identitas dan mencantumkan ‘Kepercayaan’ pada kolom agama pada kartu identitas mereka? Ataukah ini sekedar awal dari sebuah perjuangan yang masih panjang? Tulisan ini membahas bagaimana respon kelompok penghayat perempuan terkait adanya keputusan MK 97/17. Kajian literasi dilakukan disertai wawancara beberapa perempuan penghayat sebagai bahan konfirmasi data dari dokumen- dokumen yang tersedia. Pengalaman yang dimiliki perempuan tentunya berbeda dengan pengalaman laki-laki, dan tentunya mempengaruhi perempuan dalam menyikapi keputusan MK 97/17. Akhirnya agama atau kepercayaan sebagai identitas menjadi pilihan, bagaimana perempuan penghayat yang ditemui ternyata lebih memilih tidak merubah identitas mereka di kolom KTP dan KK. Mereka lebih mengutamakan membangun komunitas mereka sebagai sesama perempuan penghayat dan saling menguatkan ditengah-tengah situasi sosial politik yang kurang berpihak dan kebijakan negara masih setengah-setengah mengakui keberadaan mereka. Steve Bruce mengistilahkannya sebagai proses ‘culture transition’ yang dihadapi individu yang teralienasi didunia baru, kadangkala agama dibutuhkan demi menghindari resiko-resiko sosial dan politik sehingga mereka rela mengkosongkan atau bahkan menyembunyikan identitas diri sebagai penganut kepercayaan agar bisa diterima masyarakat luas.
Competency of Future Pediatricians Caring for Children With Behavioral and Mental Health Problems
Authors: Green Cori , Leyenaar JoAnna K. , Turner Adam L. , Leslie Laurel K.
Published: June 2020

BACKGROUND AND OBJECTIVES:

There is an urgent need to prepare pediatricians to care for children with behavioral and mental health (B/MH) conditions. In this study, we evaluate the perceived competence of pediatric residents and recent graduates in the assessment and treatment of B/MH conditions, characterize variation in competence across residency programs, and identify program characteristics associated with high competence.

METHODS:

Cross-sectional survey of applicants for the initial certifying examination in pediatrics. Questions were focused on (1) who should be competent in B/MH skills, (2) institutional support around B/MH training, and (3) perceived competence in 7 B/MH assessment skills and 9 treatment skills. Competence was rated on a 5-point scale, and high levels of assessment and treatment competence were defined as scores of ≥4. Composite measures for B/MH assessment and treatment were calculated as mean scores for each domain. We examined variation in residents’ self-reported competence across programs and used linear regression to identify factors associated with high levels of competence at the program level.

RESULTS:

Of applicants, 62.3% responded to the survey (n = 2086). Of these, 32.8% (n = 595) reported high competence in assessment skills and 18.9% (n = 337) in treatment skills. There were large variations in reported competence across programs. Respondents from smaller programs (<30 trainees) reported higher competence in assessment and treatment than those from large programs (P < .001).

CONCLUSIONS:

Current and recent pediatric trainees do not report high levels of perceived competence in the assessment and treatment of children with B/MH conditions. The substantial variation across programs indicates that the pediatric community should create standards for B/MH training.
Coronavirus Disease 2019 Myocarditis: Insights into Pathophysiology and Management
Authors: Abdelnabi Mahmoud , Eshak Nouran , Saleh Yehia , Almaghraby Abdallah
Published: June 2020

The world is dealing with a global pandemic of severe acute respiratory coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19), which is the illness caused by SARS-CoV-2, is overwhelming healthcare systems around the world. Although the main clinical manifestations of COVID-19 are respiratory symptoms, several reports have noted myocarditis, cardiomyopathy, arrhythmias and cardiac arrests as COVID-19 complications. Here, the authors highlight the current understanding of the pathophysiology of myocarditis related to COVID-19 and its management.
Evaluation of a New Multimodal Optimization Algorithm in Fluid Phase Equilibrium Problems
Authors: Platt Gustavo Mendes , Aragão Marcelo Escobar , Borges Fernanda Cabral , Goulart Douglas Alves
Published: June 2020

Multimodal optimization problems are commonly found in engineering problems, and their solution can be very challenging for metaheuristic approaches. In this work, the use of a recently proposed multimodal metaheuristic method was analyzed - the Multimodal Flower Pollination Algorithm - in two fluid phase equilibrium problems: (i) the calculation of double azeotropes and (ii) parameter estimation in a thermodynamic model. Two different formulations were also considered in the double azeotropy problem. In the azeotrope calculation, a statistical analysis was conducted in order to verify if the algorithm performance is affected by the the problem formulation. The computational results indicate that the methodology provides robust results and that the objective function employed affects the computational performance.
Rapid Drawdown in Homogeneous Earth Dam Considering Transient Flow and Suction
Authors: Llanque Ayala Grover Romer , Chagas da Silva Filho Francisco , Ferreira Leme Rosiel , Do Carmo Reis Cavalcanti Maria , Fernando Mahler Claudio
Published: June 2020

The present work intends to demonstrate the advantages of considering transient flow regime in the stability analysis of the upstream slope for the rapid drawdown situation of a homogeneous earth dam. Upstream slope stability evaluations were carried out, considering pore pressure and suction from transient flow analysis while simulating rapid drawdown of the reservoir. The evaluations comprised different geometries of the upstream slope (from 1V:1.1H to 1V:2.5H) and heights varying from 10 m to 50 m, as well as several low permeability materials (SM, SM-SC, SC, ML, ML-CL, CL, MH and CH). In addition, equations relating the safety factor to such slopes or dam height were adjusted to the analysis data, in order to define the minimum slope for a certain dam height or the maximum height for a given upstream slope. The results have shown that, considering the transient flow condition, including suction, within the slope stability analysis of the rapid drawdown situation, increases the safety factor in relation to the simplified analysis that is usually adopted. This also results in much steeper slopes (for a safety factor of 1.1) than the ones recommended by the U.S. Bureau of Reclamation (USBR), suggesting the importance of performing transient flow analysis for rapid drawdown situations and considering its results instability analysis.
Utjecaj dvaju suplemenata u hranidbi koza na tehnološka svojstva kozjeg mlijeka
Authors: Kolenc Borut , Mohar Lorbeg Petra , Čanžek Majhenič Andreja , Cividini Angela , Simčič Mojca , Treven Primož
Published: June 2020

Goat’s daily diet is usually based on grazing, hay and/or feed supplements. Feed supplements are crucial in the diet of high productive
goats to achieve their genetic potential and breeders must choose balanced feeding regime to produce large quantities of milk without affecting the technological quality of milk. In the present study, we evaluated the influence of two commercially available feed supplements on goat milk coagulation properties and rheological properties of yoghurts. Goats of the Slovenian Alpine breed (61) were fed with two feed supplements during the 3-year experiment. Feed supplement 1 (FS1) had higher proportions of barley and alfalfa, while feed supplement 2 (FS2) had added premix of minerals and vitamins and had higher proportions of wheat and sunflower meal. Con¬sequently, FS1 had more crude fibres, which is the most probable reason for approximately 15 % higher firmness, consistency and cohesiveness (P<0.05) of yoghurts in
FS1 group, compared to the FS2 group. Moreover, the rennet coagulation time (r) was shorter (P<0.05) in the FS1 group, compared to the FS2 group. Curd firmness 30 min after enzyme addition (a30) was also higher in FS1 group although the results were not statistically significant. Taking together, our results indicate that goats fed with FS1 produced milk with better technological properties compared to those fed with FS2, despite the fact that there were no significant differences in chemical composition of milk from each group. We showed that careful selection of feed supplement’s constituents could improve technological properties of goat milk. However, further studies are needed to evaluate
the mechanisms of the observed differences.
Genetic parameters and breeding values for daily milk production of Holstein cows in terms of heat stress
Authors: Vučković Goran , Bobić Tina , Mijić Pero , Gavran Mirna , Gregić Maja , Potočnik Klemen , Bogdanović Vladan , Gantner Vesna
Published: June 2020

In order to estimate the variance components as well as the breeding value for daily milk production of Holstein cows in terms of heat stress
defined as different THI threshold values (68, 70, and 72) 1,275,713 test-day records from 90,159 cows were used. Temperature-humidity index (THI) calculated from ambient temperature and relative humidity recorded
in the barns on the milk recording day was used as the measure of heat stress. Daily milk production was analysed as a bivariate variable, in the normal conditions (under the set THIthreshold value), and in terms of heat stress (above the set THIthreshold value) using a model that accounted variances due to lactation stage, calving season, age at calving, breeding region, parity, permanent environment, interaction between hear and year, and individual animal. The estimated high genetic
correlations between the daily milk production in normal and heat stress conditions, as well as high correlations among the EBVs in normal
and heat stress conditions, point out that Holstein cows with high productivity in normal condition will sustain an alike level of production even in terms of heat stress. These results indicate that the
Holstein cows are very well acclimatized to the environmental conditions at dairy farms in Croatia. However, these findings should be taken with caution, given that measurements of microclimate parameters were conducted only once at a milk recording day, so the reliability of such measurements could be questionable. In conclusion, in order to realize a completely unambiguous conclusion, further studies that include multiple daily measurements of microclimatic parameters in the farms facilities are necessary.
Nutritional value and coagulation properties of milk from local cow breeds, including the selected macro- and micronutrients and trace elements
Authors: Teter Anna , Kędzierska-Matysek Monika , Barłowska Joanna , Król Jolanta , Brodziak Aneta
Published: June 2020

The aim of the study was to assess the nutritional value of milk based on its chemical composition and content of selected minerals and to determine the coagulation properties of raw milk from native Polish breeds, i.e. the Polish Red and the White-backed, as well as locally raised Simmental cows, taking into account the production season. The research material consisted of 418 milk samples taken during the spring/summer season (April to September) and autumn/winter season (October to March). The following parameters were determined in the samples: chemical composition, energetic value, coagu¬lation properties (RCT - rennet clotting time, A30 - curd firmness, K20 - curd firming time), cheese yield, and content of K, Na, Ca, Mg, Zn, Fe, Mn, Cu, Ni and Co. The percentage of the daily allowance for Ca and Mg in children,
adolescents and adults from 250 mL of milk was determined. The milk of Polish Red cows had the highest concentration of basic nutrients (1 kg of milk provided 823.98 kcal) and the best coagulation parameters (the shortest clotting time (16:09 min, p≤0.01) and firmest curd (30.74 mm). This milk had a more beneficial nutritional profile, as it contained the
highest percentage of the recommended daily allowances of Ca and Mg among all groups. The raw milk obtained in the pasture season showed more favourable coagulation properties. The content of minerals in milk is not clearly determined by the cow breed or the season. It is probably
due to the higher levels of these nutrients in the feed, which in turn results from their content in the soil and the degree of fertilization.
Struktur Geologi Pulau Nangka, Kabupaten Belitung Timur dan Pemanfaatan Ruang Kepulauan dan Perairan sekitarnya sebagai Sentra Wisata dan Maritim
Authors: YP Fajar,
Published: June 2020

Pulau Nangka terletak di Selat Karimata  di perairan kawasan timur Kabupaten Belitung Timur, Provinsi Bangka Belitung Indonesia . Pulau ini terbesar di antara 141 pulau di perairan ini dan strategis lokasinya. Menurut hemat kami pulau ini mempunyai potensi untuk mendukung kegiatan kelautan dan perikanan di sekitar perairan Karimata. Kondisi geologi Pulau Nangka amat menarik, karena berbeda litologi dengan umumnya pulau di sekitarnyadan pulau gunung batu tersebut dipenuhi patahan dan rekahan sehingga memberikan keunikan tersendiri. Telaah struktur geologi berdasarkan data lapangan menunjukkan adanya indikasi sesar geser mengiri pada bagian tengah pulau Nangka. Namun, penerusannya kearah laut pada kedua ujung sesar tersebut tidak diketahui. Kondisi alam pulau Nangka dan pulau-pulau di sekitarnya sangat menarik sehingga dapat dimanfaatkan untuk wisata laut dan pantai, untuk tujuan penyelaman, snorkling maupun wisata di hutan mangrove.  Arus laut di sekitar lokasi ini umumnya lemah, namun didapati di beberapa bagian arus kencang, sementara kondisi karangnya bagus. Model pemanfaatan dan pengelolaan ruang Pulau Nangka sebagai kawasan wisata pulau dibahas dalam makalah ini,  kemudian hasilnya diintegrasikan dengan prinsip Penanggulangan Bencana (PB).
Skenario Tsunami Menggunakan Data Parameter Gempabumi Berdasarkan Kondisi Batimetri (Studi Kasus : Gempabumi Maluku 28 Januari 2004 )
Authors: Wallansha Robby , Setyonegoro Wiko
Published: June 2020

Maluku merupakan salah satu daerah di timur Indonesia yang memiliki potensi tsunami yang cukup tinggi, ini dibuktikan dengan lebih dari 25 kejadian tsunami yang terekam di daerah Maluku dari tahun 1629 – 2006 (katalog database tsunami online Gusiakov (2005), Puspito (2007) dan Katalog Gempa Merusak dan Tsunami BMKG), tsunami yang terbesar terjadi pada tanggal 17 Pebruari 1674 yang menewaskan lebih dari 2900 orang dengan run-up hingga mencapai 80 meter dan menghancurkan kota Ambon dan juga pada tanggal 12 Oktober 1899 yang menenggelamkan kota Amahai di Pulau Seram dengan korban tewas mencapai 4000 orang. Oleh karena itu perlu dilakukan pembuatan skenario tsunami untuk mendapatkan kemungkinan tinggi run-up yang bersumber di daerah perairan Maluku dengan menggunakan software Tsunami L-2008. Berdasarkan Katalog Gempabumi Signifikan dan Merusak 1821 – 2009 yang dikeluarkan BMKG, bahwa pada tanggal 28 Januari 2004 telah terjadi gempabumi di Maluku mengakibatkan tsunami yang terobservasi di Namlea, dengan epicenter 3,110 LS – 127,300 BT dengan kekuatan Mw = 6,6 SR. Dalam pembuatan skenario tsunami dalam penelitian ini dengan merubah nilai magnituda gempabumi (Mw=7,0 SR, Mw=7,5 SR. Mw=8,0 SR) berdasarkan referensi setelah itu menggunakan hubungan rumusan empiris dari Hanks and Kanamori untuk mendapatkan nilai slip (m) sekaligus membuat beberapa kombinasi skenario tsunamidengan mempertahankan nilai momen seismik dan merubah nilai luas fault dan slip (m), untuk momen seismik didapatkan berdasarkan rumusan empiris dari Wells and Coppersmith (1994) sedangkan untuk luas fault berdasarkan rumusan empiris dari  Papazachos et al (2004) dengan mengasumsikan bahwa luas fault berbentuk persegi panjang. Dari sebelas skenario tsunami yang dibuat dari setiap magnituda gempabumi diperoleh tinggi run-up tertinggi untuk Mw=7,0 SR yaitu dengan tinggi 0,59 m di daerah Huamual sedangkan terendah di daerah Latuhalat dengan tinggi run-up 0,09 m, untuk Mw = 7,5 SR diperoleh tinggi run-up tertinggi mencapai 2,73 m di Huamual dan terendah 0,36 di Latuhalat, dan untuk Mw = 8,0 SR didapatkan tinggi run-up tertinggi hingga 8,19 m di Huamual dan terendah di Latuhalat dengan tinggi run-up 0,94 m.