bluuebunny/crossref_metadata_2025 huggingface dataset:
An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha)
Authors: Bashir Arsalan , Nabi Masarat , Tabassum Nahida , Afzal Suhaib , Ayoub Mehrose
Published: March 2023

Withania somnifera (L.) Dunal belongs to the nightshade family Solanaceae and is commonly known as Ashwagandha. It is pharmacologically a significant medicinal plant of the Indian sub-continent, used in Ayurvedic and indigenous systems of medicine for more than 3,000 years. It is a rich reservoir of pharmaceutically bioactive constituents known as withanolides (a group of 300 naturally occurring C-28 steroidal lactones with an ergostane-based skeleton). Most of the biological activities of W. somnifera have been attributed to two key withanolides, namely, withaferin-A and withanolide-D. In addition, bioactive constituents such as withanosides, sitoindosides, steroidal lactones, and alkaloids are also present with a broad spectrum of therapeutic potential. Several research groups worldwide have discovered various molecular targets of W. somnifera, such as inhibiting the activation of nuclear factor kappa-B and promoting apoptosis of cancer cells. It also enhances dopaminergic D2 receptor activity (relief in Parkinson’s disease). The active principles such as sitoindosides VII-X and withaferin-A possess free radical properties. Withanolide-D increases the radio sensitivity of human cancer cells via inhibiting deoxyribonucleic acid (DNA) damage to non-homologous end-joining repair (NHEJ) pathways. Withanolide-V may serve as a potential inhibitor against the main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to combat COVID. The molecular docking studies revealed that the withanolide-A inhibits acetyl-cholinesterase in the brain, which could be a potential drug to treat Alzheimer’s disease. Besides, withanolide-A reduces the expression of the N-methyl-D-aspartate (NMDA) receptor, which is responsible for memory loss in epileptic rats. This review demonstrates that W. somnifera is a rich source of withanolides and other bioactive constituents, which can be used as a safe drug for various chronic diseases due to the minimal side effects in various pre-clinical studies. These results are interesting and signify that more clinical trials should be conducted to prove the efficacy and other potential therapeutic effects in human settings.
Ginkgo biloba extract EGb 761® improves cognition and overall condition after ischemic stroke: Results from a pilot randomized trial
Authors: Cui Mei , You Tongyao , Zhao Yuwu , Liu Ruozhuo , Guan Yangtai , Liu Jianren , Liu Xueyuan , Wang Xin , Dong Qiang
Published: March 2023

Background: Patients who experienced an ischemic stroke are at risk for cognitive impairment. Quantified Ginkgo biloba extract EGb 761® has been used to treat cognitive dysfunction, functional impairment and neuropsychiatric symptoms in mild cognitive impairment and dementia.

Objectives: To assess the cognitive-related effects of EGb 761® treatment in patients after acute ischemic stroke, as well as the feasibility of patient selection and outcome measures.

Methods: We conducted a randomized, multicentric, open-label trial at 7 centers in China. Patients scoring 20 or lower on the National Institutes of Health Stroke Scale were enrolled between 7 and 14 days after stroke onset and randomly assigned to receive 240 mg per day of EGb 761® or no additional therapy for 24 weeks in a 1:1 ratio. Both groups received standard treatments for the prevention of recurrent stroke during the trial. General cognitive function and a battery of cognitive tests for sub-domains were evaluated at 24 weeks. All patients were monitored for adverse events.

Results: 201 patients ≥50 years old were included, with 100 assigned to the EGb 761® group and 101 to the reference group. The mean change from baseline on the global cognitive function as assessed by the Montreal Cognitive Assessment score was 2.92 in the EGb 761® group and 1.33 in the reference group (between-group difference: 1.59 points; 95% confidence interval [CI], 0.51 to 2.67; p < 0.005). For cognitive domains, EGb 761® showed greater effects on the Hopkins Verbal Learning Test Total Recall (EGb 761® change 1.40 vs. reference −0.49) and Form 1 of the Shape Trail Test (EGb 761® change −38.2 vs. reference −15.6). Potentially EGb 761®-related adverse events occurred in no more than 3% of patients.

Conclusion: Over the 24-week period, EGb 761® treatment improved overall cognitive performance among patients with mild to moderate ischemic stroke. Our findings provide valuable recommendations for the design of future trials, including the criteria for patient selection.

Clinical Trial Registration:www.isrctn.com, identifier ISRCTN11815543.
Effects of saponins from Chinese herbal medicines on signal transduction pathways in cancer: A review
Authors: Zhu Mingtao , Sun Yanping , Bai Haodong , Wang Yimeng , Yang Bingyou , Wang Qiuhong , Kuang Haixue
Published: March 2023

Cancer poses a serious threat to human health, and the search for safe and effective drugs for its treatment has aroused interest and become a long-term goal. Traditional Chinese herbal medicine (TCM), an ancient science with unique anti-cancer advantages, has achieved outstanding results in long-term clinical practice. Accumulating evidence shows that saponins are key bioactive components in TCM and have great research and development applications for their significant role in the treatment of cancer. Saponins are a class of glycosides comprising nonpolar triterpenes or sterols attached to hydrophilic oligosaccharide groups that exert antitumor effects by targeting the NF-κB, PI3Ks-Akt-mTOR, MAPK, Wnt-β-catenin, JAK-STAT3, APMK, p53, and EGFR signaling pathways. Presently, few advances have been made in physiological and pathological studies on the effect of saponins on signal transduction pathways involved in cancer treatment. This paper reviews the phytochemistry and extraction methods of saponins of TCM and their effects on signal transduction pathways in cancer. It aims to provide theoretical support for in-depth studies on the anticancer effects of saponins.
Effects of various interventions on non-alcoholic fatty liver disease (NAFLD): A systematic review and network meta-analysis
Authors: Wang Xinchen , Jin Xiaoqian , Li Hancheng , Zhang Xianyu , Chen Xi , Lu Kuan , Chu Chenliang
Published: March 2023

Background: With the increasing prevalence of obesity and metabolic syndrome, the incidence of non-alcoholic fatty liver disease (NAFLD) is also increasing. In the next decade, NAFLD may become the main cause of liver transplantation. Therefore, the choice of treatment plan is particularly important. The purpose of this study was to compare several interventions in the treatment of NAFLD to provide some reference for clinicians in selecting treatment methods.

Methods: We searched Public Medicine (PubMed), Medline, Excerpta Medica Database (Embase), and Cochrane Library from January 2013 to January 2023 to identify randomized controlled trials (RCTs) published in English. The network meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Forty-three studies accounting for a total of 2,969 patients were included, and alanine aminotransferase (ALT), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL) were selected as outcome measures for analysis and comparison.

Results: We evaluated the results of drug, diet, and lifestyle interventions between the intervention and control groups. Curcumin (CUN) and probiotics (PTC) were selected for medication, the Mediterranean diet (MDED) was selected for special diet (SPD), and various kinds of exercise and lifestyle advice were selected for lifestyle interventions (LFT). The SUCRA was used to rank interventions according to the effect on ALT indicators (SUCRA: PTC 80.3%, SPD 65.2%, LFT 61.4%, PLB 32.8%, CUN 10.2%), TC indicators (SUCRA: PTC 89.4%, SPD 64%, CUN 34%, LFT 36.6%, PLB 17%), and LDL indicators (SUCRA: PTC 84.2%, CUN 69.5%, LFT 51.7%, PLB 30.1%, SPD 14.5%). The pairwise meta-analysis results showed that MDED was significantly better than NT in improving ALT [SMD 1.99, 95% CI (0.38, 3.60)]. In terms of improving TC and LDL, ATS was significantly better than NT [SMD 0.19, 95% CI (0.03, 0.36)] [SMD 0.18, 95% CI (0.01, 0.35)].

Conclusion: Our study showed that PTC is most likely to be the most effective treatment for improving NAFLD indicators. Professional advice on diet or exercise was more effective in treating NAFLD than no intervention.
Effect of kinesio taping intervention on the muscle strength and balance of college basketball players with functional ankle instability
Authors: Li Rui , Qin Rui , Tan Yajun , Liu Hengxian , Wang Kun , Cheng Liang
Published: March 2023

Objective: The aim of this study was to investigate the effects of acute Kinesio Taping (KT) intervention on the muscle strength and balance ability of college basketball players with functional ankle instability (FAI).

Methods: Thirty college basketball players with FAI were treated with acute KT to test the changes in their muscle strength and balance ability.

Results: After acute KT intervention, the ankle dorsiflexion moment and the ankle plantar flexion moment increased by 34% and 19.9%, respectively. The stable plane test with the subjects’ eyes open decreased by 1%, whereas that with the subjects’ eyes closed decreased by 1.1%. The swaying environment test with the subjects’ eyes open increased by 2.4%. The swaying plane test with the subjects’ eyes open increased by 5.1%, whereas that with the subjects’ eyes closed increased by 16.2%. The swaying environment test with the subjects’ eyes open plus the use of a plane increased by 12.1%.

Conclusion: KT can increase the isokinetic strength of the ankle dorsum muscle and plantar flexion of college basketball players with FAI. The effect of KT in the static balance test was weaker than that in the dynamic balance test. The findings indicate that KT can significantly improve the balance ability of college basketball players with FAI during dynamic sports.
Analysis of skeletal stem cells by renal capsule transplantation and ex vivo culture systems
Authors: Hsu Wei , Maruyama Takamitsu
Published: March 2023

Skeletal stem cells residing in the suture mesenchyme are responsible for proper development, homeostasis, and injury repair of the craniofacial skeleton. These naïve cells are programmed to differentiate into osteoblast cell types and mediate bone formation via an intramembranous ossification mechanism. The simplicity of this system also offers great advantages to studying osteoblastogenesis compared to the appendicular and axial skeletons. Recent studies utilizing genetically based cell tracing have led to the identification of skeletal stem cell populations in craniofacial and body skeletons. Although the genetic analysis indicates these cells behave like stem cells in vivo, not all of them have been thoroughly examined by stem cell isolation and stem cell-mediated tissue generation. As regeneration is an integral part of stem cell characteristics, it is necessary to further analyze their ability to generate tissue at the ectopic site. The establishment of an ex vivo culture system to maintain the stemness properties for extended periods without losing the regenerative ability is also pertinent to advance our knowledge base of skeletal stem cells and their clinical applications in regenerative medicine. The purpose of this review is to discuss our recent advancements in analyses of skeletal stem cells using renal capsule transplantation and sphere culture systems.
Chronic environmental circadian disruption increases atherosclerosis and dyslipidemia in female, but not male, ApolipoproteinE-deficient mice
Authors: Chalfant Jeffrey M. , Howatt Deborah A. , Johnson Victoria B. , Tannock Lisa R. , Daugherty Alan , Pendergast Julie S.
Published: March 2023

Shift work chronically disrupts circadian rhythms and increases the risk of developing cardiovascular disease. However, the mechanisms linking shift work and cardiovascular disease are largely unknown. The goal of this study was to investigate the effects of chronically shifting the light-dark (LD) cycle, which models the disordered exposure to light that may occur during shift work, on atherosclerosis. Atherosclerosis is the progressive accumulation of lipid-filled lesions within the artery wall and is the leading cause of cardiovascular disease. We studied ApolipoproteinE-deficient (ApoE−/−) mice that are a well-established model of atherosclerosis. Male and female ApoE−/− mice were housed in control 12L:12D or chronic LD shift conditions for 12 weeks and fed low-fat diet. In the chronic LD shift condition, the light-dark cycle was advanced by 6 h every week. We found that chronic LD shifts exacerbated atherosclerosis in female, but not male, ApoE−/− mice. In females, chronic LD shifts increased total serum cholesterol concentrations with increased atherogenic VLDL/LDL particles. Chronic LD shifts did not affect food intake, activity, or body weight in male or female ApoE−/− mice. We also examined eating behavior in female ApoE−/− mice since aberrant meal timing has been linked to atherosclerosis. The phases of eating behavior rhythms, like locomotor activity rhythms, gradually shifted to the new LD cycle each week in the chronic LD shift group, but there was no effect of the LD shift on the amplitudes of the eating rhythms. Moreover, the duration of fasting intervals was not different in control 12L:12D compared to chronic LD shift conditions. Together these data demonstrate that female ApoE−/− mice have increased atherosclerosis when exposed to chronic LD shifts due to increased VLDL/LDL cholesterol, independent of changes in energy balance or feeding-fasting cycles.
NAC103 mutation alleviates DNA damage in an Arabidopsis thaliana mutant sensitive to excess boron
Authors: Sotta Naoyuki , Sakamoto Takuya , Kamiya Takehiro , Tabata Ryo , Yamaguchi Katsushi , Shigenobu Shuji , Yamada Masashi , Hasebe Mitsuyasu , Sawa Shinichiro , Fujiwara Toru
Published: March 2023

Excess boron (B) is toxic to plants and thereby causes DNA damage and cell death in root meristems. However, the underlying mechanisms which link boron and DNA damage remain unclear. It has been reported that the rpt5a-6 mutant of the 26S proteasome is sensitive to excess boron, resulting in more frequent cell death in root meristem and reduced root elongation. In this study, we showed that a reduction in root growth in the rpt5a mutant in the presence of high boron levels is repressed by a mutation in NAC domain containing transcription factor NAC103, a substrate of the proteasome, which functions in the unfolded protein response pathway. The mutation in NAC103 alleviated excess-B-induced DNA damage and cell death in root meristems of the rpt5a mutant. Superoxide (O2−) staining with nitroblue tetrazolium revealed that boron stress causes O2− accumulation in root tips, which was higher in the rpt5a-6 mutant, whereas the accumulation was lower in the rpt5a-6 nac103-3 double mutant. Our work demonstrates the overall involvement of NAC103 in maintaining healthy root meristem under excess boron conditions in the absence of RPT5A proteasome subunit.
Improved cotton yield: Can we achieve this goal by regulating the coordination of source and sink?
Authors: Qin Aizhi , Aluko Oluwaseun Olayemi , Liu Zhixin , Yang Jincheng , Hu Mengke , Guan Liping , Sun Xuwu
Published: March 2023

Cotton is one of the major cash crops globally. It is characterized by determinate growth and multiple fruiting, which makes the source–sink contradiction more obvious. Coordination between source and sink is crucial for normal growth, yield, and quality of cotton. Numerous studies reported how the assimilate transport and distribution under varying environmental cues affected crop yields. However, less is known about the functional mechanism underlying the assimilate transport between source and sink, and how their distribution impacts cotton growth. Here, we provided an overview of the assimilate transport and distribution mechanisms , and discussed the regulatory mechanisms involved in source-sink balance in relation to cotton yield. Therefore, this review enriched our knowledge of the regulatory mechanism involved in source–sink relationship for improved cotton yield.
“Canopy fingerprints” for characterizing three-dimensional point cloud data of soybean canopies
Authors: Young Therin J. , Jubery Talukder Z. , Carley Clayton N. , Carroll Matthew , Sarkar Soumik , Singh Asheesh K. , Singh Arti , Ganapathysubramanian Baskar
Published: March 2023

Advances in imaging hardware allow high throughput capture of the detailed three-dimensional (3D) structure of plant canopies. The point cloud data is typically post-processed to extract coarse-scale geometric features (like volume, surface area, height, etc.) for downstream analysis. We extend feature extraction from 3D point cloud data to various additional features, which we denote as ‘canopy fingerprints’. This is motivated by the successful application of the fingerprint concept for molecular fingerprints in chemistry applications and acoustic fingerprints in sound engineering applications. We developed an end-to-end pipeline to generate canopy fingerprints of a three-dimensional point cloud of soybean [Glycine max (L.) Merr.] canopies grown in hill plots captured by a terrestrial laser scanner (TLS). The pipeline includes noise removal, registration, and plot extraction, followed by the canopy fingerprint generation. The canopy fingerprints are generated by splitting the data into multiple sub-canopy scale components and extracting sub-canopy scale geometric features. The generated canopy fingerprints are interpretable and can assist in identifying patterns in a database of canopies, querying similar canopies, or identifying canopies with a certain shape. The framework can be extended to other modalities (for instance, hyperspectral point clouds) and tuned to find the most informative fingerprint representation for downstream tasks. These canopy fingerprints can aid in the utilization of canopy traits at previously unutilized scales, and therefore have applications in plant breeding and resilient crop production.
A contribution to the Italian validation of the Parenting Interaction with Children: Checklist of Observations Linked to Outcome (PICCOLO)
Authors: Montirosso Rosario , Castagna Annalisa , Butti Niccolò , Innocenti Mark S. , Roggman Lori A. , Rosa Elisa
Published: March 2023

Introduction

PICCOLO (Parenting Interactions with Children: Checklist of Observations Linked to Outcomes) is an observational instrument designed to assess four domains of parenting interactions that promote early child development (Affection, Responsiveness, Encouragement, and Teaching). Although PICCOLO has been validated in the United States for children as young as 4 months of age, the current focus is on parents with children aged between 10 and 47 months. This study contributes to the validation of the Italian translation of the PICCOLO by testing its psychometric properties and examining whether factors such as the child’s age and child’s sex are related to the four domains of parenting interactions.

Methods

To these aims, 152 mothers of children aged 10–47 months from three Italian regions participated in the study.

Results

Results indicate that the PICCOLO Italian version has acceptable inter-rater agreement, split-half reliability, and stability over time. Furthermore, the Italian version confirmed the robustness of the factor structure proposed in the original version. While there were no significant differences by child gender on the domains of parenting interactions, the Affection scores decreased with age.

Discussion

Overall, these results demonstrate that the Italian version of the PICCOLO is a reliable measure of maternal interactions with children. The psychometric properties of the instrument make it appropriate for general research purposes and for assessment of parenting before and after support interventions.
Radicalization and violent extremism depend on envy; conspiracy ideation, sometimes
Authors: Moncrieff Michael , Lienard Pierre
Published: March 2023

Emotions are conspicuous components of radicalization, violent extremism, and conspiracy ideation. Of the emotions studied for their contribution to those social pathologies, envy has been relatively unexplored. We investigate the relationship between envy, radicalization, and conspiracy ideation. Envy appears to affect core aspects of radicalization, particularly the endorsement of extremism and the acceptance of violent means to achieve one’s ends, while radicalization facilitates the adoption of conspiracy ideation, rather than the latter being a cause of radicalization. Implications for future research on radicalization and violent extremism are discussed.
Work addiction, work engagement, job burnout, and perceived stress: A network analysis
Authors: Bereznowski Piotr , Atroszko Paweł Andrzej , Konarski Roman
Published: March 2023

Introduction

Recently, the network theory of mental disorders has been used to conceptualize work addiction as a dynamic system of symptoms in direct relationships. This study aimed to extend previous work by investigating the direct relationships of work addiction symptoms with dimensions of work engagement, job burnout, and perceived stress.

Methods

These phenomena were measured with the Bergen Work Addiction Scale, the Utrecht Work Engagement Scale, the Maslach Burnout Inventory–General Survey, and the Perceived Stress Scale. The sample comprised 676 working Poles with a mean age of 36.12 years (SD = 11.23). The network analysis followed the guidelines for estimating psychological networks from cross-sectional data.

Results

Work engagement and job burnout were more closely associated with each other than with work addiction which supports the notion that engagement and burnout represent polar opposites of the same construct and that work addiction is a separate phenomenon, related to both work engagement and job burnout via specific pathways. The symptoms of work addiction were connected with other phenomena through four direct relationships: (1) mood modification—absorption, (2) mood modification—stress, (3) withdrawal—absorption, and (4) problems—exhaustion.

Discussion

These findings narrow down and specify hypotheses regarding potential mechanisms leading from engagement to addiction and from addiction to burnout. The possible mechanisms focus on the absorption component and mood modification related to efforts focused on alleviating chronic stress and negative emotional states. In turn, problems arising from work addiction may lead to exhaustion. Future studies investigating these mechanisms in detail may enable proper prevention programs and therapeutic interventions.
Effects of a polyphenol-rich grape and blueberry extract (Memophenol™) on cognitive function in older adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study
Authors: Lopresti Adrian L. , Smith Stephen J. , Pouchieu Camille , Pourtau Line , Gaudout David , Pallet Véronique , Drummond Peter D.
Published: March 2023

Background

Polyphenols are naturally occurring organic compounds found in plants. Research suggests that their intake reduces the risk of cognitive decline and related dementias. Grapes and blueberries are polyphenol-rich foods that have attracted attention for their potential cognitive-enhancing effects.

Purpose

Examine the effects of supplementation with a standardized and patented polyphenol-rich grape and blueberry extract (Memophenol™) on cognitive function in older adults with mild cognitive impairment.

Study design

Two-arm, 6 month, parallel-group, randomized, double-blind, placebo-controlled trial.

Methods

One hundred and forty-three volunteers aged 60 to 80 years with mild cognitive impairment were supplemented with either 150 mg of Memophenol™, twice daily or a placebo. Outcome measures included computer-based cognitive tasks, the Behavior Rating Inventory of Executive Function (BRIEF-A), the Cognitive Failures Questionnaire, and the CASP-19.

Results

Compared to the placebo, Memophenol™ supplementation was associated with greater improvements in the speed of information processing (p = 0.020), visuospatial learning (p = 0.012), and the BRIEF-A global score (p = 0.046). However, there were no other statistically significant between-group differences in the performance of other assessed cognitive tests or self-report questionnaires. Memophenol™ supplementation was well-tolerated with no reports of significant adverse reactions.

Conclusion

The promising results from this trial suggest that 6-months of supplementation with Memophenol™ may improve aspects of cognitive function in adults with mild cognitive impairment. Further research will be important to expand on the current findings and identify the potential mechanisms of action associated with the intake of this polyphenol-rich extract.
Analysis of the value of folk music intangible cultural heritage on the regulation of mental health
Authors: Ning Hui
Published: March 2023

This paper proposes an approach based on the safeguarding of intangible cultural heritage (ICH) by studying the value of ICH to explore the value of the ICH of folk music on mental health and its safeguarding measures. Additionally, a questionnaire survey is conducted on the value of the ICH of folk music among college students. The Tibetan Guozhuang dance and music in the ICH are taken as the object. The students’ awareness, participation, and effects on physical and mental health, emotional regulation, and stress regulation are investigated, to study the safeguarding value of folk music. The survey results reveal that in the process of participating in the folk art of Tibetan Guozhuang dance, 41.8% of the students consider it very useful for emotional regulation and stress relief, and 46.31% believe it is useful. 36.95% of the students feel that it is very useful for the development of mental health, and 49.75% think it is useful. This indicates that a total of 86.7% of the students believe that the dance is helpful to the development of students’ mental health. And most of the students are in a happy mood when participating in the dance. Among them, 71.7% of the students say that they are elated, and 66.98% feel that they are excited. It illustrates that as a young group, the students are fond of folk art, but they lack the cognitive approach. Finally, the safeguarding suggestions and implementation paths are put forward in view of the existing problems of the ICH of folk music. The research can provide a research reference for the safeguarding of the ICH of folk music.
A Transdiagnostic group therapy for sleep and anxiety among adults with substance use disorders: Protocol and pilot investigation
Authors: Milanak Melissa E. , Witcraft Sara M. , Park Jie Young , Hassell Katharine , McMahon Tierney , Wilkerson Allison K.
Published: March 2023

Introduction

Treatment of substance use disorders (SUDs) is challenging with high rates of treatment dropout and relapse, particularly among individuals with comorbid psychiatric conditions. Anxiety and insomnia are prevalent among those with SUD and exacerbate poor treatment outcomes. Interventions that concurrently target anxiety and insomnia during the early stages of SUD treatment are lacking. To this end, we investigated the feasibility and preliminary effectiveness in a single-arm pilot trial of an empirically informed group transdiagnostic intervention, Transdiagnostic SUD Therapy, to concurrently reduce anxiety and improve sleep among adults receiving treatment for SUD. Specifically, we hypothesized that participants would evidence declines in anxiety and insomnia and improvements in sleep health, a holistic, multidimensional pattern of sleep-wakefulness that promotes wellbeing. A secondary aim was to describe the protocol for Transdiagnostic SUD Therapy and how it may be implemented into a real-world addiction treatment setting.

Method

Participants were 163 adults (Mage = 43.23; 95.1% White; 39.93% female) participating in an intensive outpatient program for SUD who attended at least three of four Transdiagnostic SUD Therapy sessions. Participants had diverse SUDs (58.3% alcohol use disorder, 19.0% opioid use disorder) and nearly a third of the sample met criteria for two SUDs and comorbid mental health diagnoses (28.9% anxiety disorder, 24.6% major depressive disorder).

Results

As anticipated, anxiety and insomnia reduced significantly across the 4-week intervention period from clinical to subclinical severity, and sleep health significantly improved (ps < 0.001). These statistically significant improvements following Transdiagnostic SUD Therapy demonstrated medium to large effects (ds > 0.5).

Conclusion

Transdiagnostic SUD Therapy is designed to be flexibly administered in “real-world” clinical settings and, preliminarily, appears to be effective in improving emotional and behavioral factors that increase risk for return to substance use and poor SUD treatment outcomes. Additional work is needed to replicate these findings, determine the feasibility of widespread uptake of Transdiagnostic SUD Therapy, and examine whether the treatment effects translate to improvement in substance use outcomes.
Epidemiological characteristics of overseas imported COVID-19 cases into China: A scoping literature review
Authors: Zhang Zitong , Chen Yifeng , Li Qingyu , Yang Yan , Chen Jiake , Lin Yan , Xiao Zhihong , Ma Marie , Wu Chuancheng , Liu Baoying , Xu Rongxian , Xiang Jianjun
Published: March 2023

Previous studies investigating the characteristics of imported cases were mostly limited to a certain province/city or a specific sub-group during a certain period with a small sample size, which may not provide an overall picture of the characteristics of imported cases. In this scoping literature review, we comprehensively synthesized the epidemiological characteristics of overseas imported COVID-19 cases into China by retrieving six literature databases, with aims to provide implications for more targeted control, prevention, and medical treatment of this disease. After dropping duplicates and reviewing titles, abstracts, and full-texts, 50 articles were included in the review finally, including 26 (52%) articles in English and 24 (48%) articles in Chinese. According to the type of data sources, the 50 studies were divided into three categories: 13 (26%) articles using data sourced from the Chinese Infectious Diseases Online Reporting System, 15 (30%) articles using data from the websites of national/local health departments, and 22 (44%) articles using hospital admission data. Most of the overseas imported COVID-19 cases were young and middle-aged Chinese students and businessmen returning from the United States, Europe, and some neighboring countries. Airport routine health screening measures could not identify COVID-cases effectively, although scheduled multiple nucleic acid tests were required before boarding. Almost all imported cases were identified during the hotel quarantine period. Although a large proportion of imported cases were asymptomatic or with mild symptoms in the published literature, they may be due to participant selection bias. The exact proportion of asymptomatic cases may need to be further investigated especially through population-based large-scale studies.
OSM-SLAM: Aiding SLAM with OpenStreetMaps priors
Authors: Frosi Matteo , Gobbi Veronica , Matteucci Matteo
Published: March 2023

In the last decades, Simultaneous Localization and Mapping (SLAM) proved to be a fundamental topic in the field of robotics, due to the many applications, ranging from autonomous driving to 3D reconstruction. Many systems have been proposed in literature exploiting a heterogeneous variety of sensors. State-of-the-art methods build their own map from scratch, using only data coming from the equipment of the robot, and not exploiting possible reconstructions of the environment. Moreover, temporary loss of data proves to be a challenge for SLAM systems, as it demands efficient re-localization to continue the localization process. In this paper, we present a SLAM system that exploits additional information coming from mapping services like OpenStreetMaps, hence the name OSM-SLAM, to face these issues. We extend an existing LiDAR-based Graph SLAM system, ART-SLAM, making it able to integrate the 2D geometry of buildings in the trajectory estimation process, by matching a prior OpenStreetMaps map with a single LiDAR scan. Each estimated pose of the robot is then associated with all buildings surrounding it. This association allows to improve localization accuracy, but also to adjust possible mistakes in the prior map. The pose estimates coming from SLAM are then jointly optimized with the constraints associated with the various OSM buildings, which can assume one of the following types: Buildings are always fixed (Prior SLAM); buildings surrounding a robot are movable in chunks, for every scan (Rigid SLAM); and every single building is free to move independently from the others (Non-rigid SLAM). Lastly, OSM maps can also be used to re-localize the robot when sensor data is lost. We compare the accuracy of the proposed system with existing methods for LiDAR-based SLAM, including the baseline, also providing a visual inspection of the results. The comparison is made by evaluating the estimated trajectory displacement using the KITTI odometry dataset. Moreover, the experimental campaign, along with an ablation study on the re-localization capabilities of the proposed system and its accuracy in loop detection-denied scenarios, allow a discussion about how the quality of prior maps influences the SLAM procedure, which may lead to worse estimates than the baseline.
Polyvinyl chloride-added dibutyl adipate for high-performance electrohydrodynamic pumps
Authors: Shimizu Keita , Murakami Kazuya , Ogawa Naoki , Akai Hideko , Shintake Jun
Published: March 2023

Electrohydrodynamic (EHD) pumps are a promising driving source for various fluid-driven systems owing to features such as simple structure and silent operation. The performance of EHD pumps depends on the properties of the working fluid, such as conductivity, viscosity, and permittivity. This implies that the tuning of these parameters in a working fluid can enhance the EHD performance. This study reports a method to modify the properties of a liquid for EHD pumps by mixing an additive. Specifically, dibutyl adipate (DBA) and polyvinyl chloride (PVC) are employed as the working fluid and the additive, respectively. The results show that when the concentration of PVC is 0.2%, the flow rate and pressure at applied voltage of 8 kV take highest value of 7.85 μL/s and 1.63 kPa, respectively. These values correspond to an improvement of 109% and 40% for the flow rate and pressure, respectively, compared to the pure DBA (PVC 0%). When the voltage is 10 kV, the flow rate of 10.95 μL/s and the pressure of 2.07 kPa are observed for DBA with PVC concentration of 0.2%. These values are more than five times higher than those observed for FC40 at the same voltage (2.02 μL/s and 0.32 kPa). The results also suggest that optimal conductivity and viscosity values exist for maximizing the EHD performance of a liquid. This demonstrates the validity of the proposed method for realizing high-performance EHD pumps by using additives in the working fluid.
Parameter search of a CPG network using a genetic algorithm for a snake robot with tactile sensors moving on a soft floor
Authors: Tamura Hajime , Kamegawa Tetsushi
Published: March 2023

When a snake robot explores a collapsed house as a rescue robot, it needs to move through various obstacles, some of which may be made of soft materials, such as mattresses. In this study, we call mattress-like environment as a soft floor, which deforms when some force is added to it. We focused on the central pattern generator (CPG) network as a control for the snake robot to propel itself on the soft floor and constructed a CPG network that feeds back contact information between the robot and the floor. A genetic algorithm was used to determine the parameters of the CPG network suitable for the soft floor. To verify the obtained parameters, comparative simulations were conducted using the parameters obtained for the soft and hard floor, and the parameters were confirmed to be appropriate for each environment. By observing the difference in snake robot’s propulsion depending on the presence or absence of the tactile sensor feedback signal, we confirmed the effectiveness of the tactile sensor considered in the parameter search.
Whose responsibility is it to talk with children and young people about intersex/differences in sex development? Young people’s, caregivers’ and health professionals’ perspectives
Authors: Roen Katrina , Lundberg Tove , Hegarty Peter , Liao Lih-Mei
Published: March 2023

Introduction

Over the past two decades, there has been a shift from concealing diagnoses of sex development from impacted people to the broad principle of age-appropriate disclosure. This change is consistent with children’s rights and with general shifts towards giving children medical information and involving patients in medical decision-making. The present paper examines how health professionals, young people and caregivers with experience in this area talk about the process of telling children about a diagnosis relating to sex development. The focus is on (i) who is given the role of talking with children and young people about their medical condition and care in the context of a diagnosis relating to sex development and (ii) what strategies seem to work, and what dilemmas are encountered, in engaging children and young people in talk about their condition and healthcare.

Method

Qualitative semi-structured interviews were carried out with 32 health professionals, 28 caregivers and 12 young persons recruited in the UK and Sweden, and thematic analysis was undertaken.

Results

The analysis identifies strategies and dilemmas in communication and a widespread assumption that it is caregivers’ responsibility to talk with children/young people about the diagnosis. This assumption creates difficulties for all three parties. This paper raises concern about children/young people who, despite a more patient-centred care ethos, are nevertheless growing up with limited opportunities to learn to talk about intersex or differences in sex development with confidence.

Discussion

Learning to talk about this topic is one step towards shared decision-making in healthcare. A case is made for services to take clearer responsibility for developing a protocol for educating children and young people in ways that involve caregivers. Such a process would include relevant medical information as well as opportunities to explore preferred language and meaning and address concerns of living well with bodily differences.
Electron magnetohydrodynamics Grad–Shafranov reconstruction of the magnetic reconnection electron diffusion region
Authors: Korovinskiy D. , Panov E. , Nakamura R. , Kiehas S. , Hosner M. , Schmid D. , Ivanov I.
Published: March 2023

We present a study of the electron magnetohydrodynamics Grad–Shafranov (GS) reconstruction of the electron diffusion region (EDR) of magnetic reconnection. Two-dimensionality of the magnetoplasma configuration and steady state are the two basic assumptions of the GS reconstruction technique, which represent the method’s fundamental limitations. The present study demonstrates that the GS reconstruction can provide physically meaningful results even when these two assumptions, which are hardly fulfilled in spacecraft observations, are violated. This conclusion is supported by the reconstruction of magnetic configurations of two EDRs, encountered by the Magnetospheric Multiscale (MMS) Mission on July 11, 2017 and September 8, 2018. Here, the former event exhibited a violation of two-dimensionality, and the latter event exhibited a violation of steady state. In both cases, despite the deviations from the ideal model configuration, reasonable reconstruction results are obtained by implementing the herein introduced compressible GS reconstruction model. In addition to the discussed fundamental limitations, all existing versions of the GS reconstruction technique rely on a number of minor simplifying assumptions, which restrict the model scope and efficiency. We study the prospects for further model improvement and generalization analytically. Our analysis reveals that nearly all these minor limitations can be overcome by using a polynomial MMS-tailored reconstruction technique in the space of rotationally invariant variables instead of Cartesian coordinates.
Status of animal health biosecurity measures of dairy farms in urban and peri-urban areas of central Ethiopia
Authors: Moje Nebyou , Waktole Hika , Kassahun Rediet , Megersa Bekele , Chomen Milkessa T. , Leta Samson , Debela Mulu , Amenu Kebede
Published: March 2023

Ethiopian dairy farming has many constraints including disease and lack of appropriate biosecurity measures. With this into consideration, a cross-sectional survey was carried out from November 2021 to April 2022 to determine the animal health biosecurity status of dairy farms and investigate the sociodemographic characteristics of livestock keepers on dairy farm management. A face-to-face questionnaire survey using an online application was used to collect data. The interview involved a total of 380 dairy farms located in six towns in central Ethiopia. The results showed that out of the surveyed farms, 97.6% missed footbaths at their gate points, 87.4% lacked isolation areas for either sick or newly introduced cattle, and 83.4% did not check the health status or quarantine newly introduced cattle. Furthermore, written formal record-keepings on animal health was uncommon, except for a few farms (7.9%). However, nearly all of the respondents (97.9%) gave medical treatments for sick cattle, and 57.1% of them vaccinated their herds regularly during the past 12 months before the survey. Hygienic aspects of the farms showed that 77.4% of the dairy farms appeared to clean the barn on a daily basis. However, 53.2% of respondents did not utilize personal protective equipment while cleaning their farms. A quarter of the dairy farmer (25.8%) avoided mixing their cattle with other herds, and 32.9% of them have implemented isolation of sick animals. In general, the animal health biosecurity assessment of the farms showed that most of the dairy farms (79.5%) earned unacceptable biosecurity levels (score of ≤ 50%), whereas the remaining 20.5% of dairy farms had received a score of >50% (“acceptable level”). The gender of dairy farmers (χ2 value = 7.61; p = 0.006), education level (χ2 value = 12.04; p = 0.007), dairy farm ownership (χ2 value = 41.6; p < 0.001), training on dairy farm management (χ2 value = 37.1; p < 0.001), towns (χ2 value = 31.69; p < 0.001), farm size (χ2 value = 7.7; p = 0.006), and herd size (χ2 value = 28.2; p < 0.001) showed a significant statistical association with biosecurity status. Finally, the study revealed that the level of biosecurity adoption of dairy farms in central Ethiopia is mostly unsatisfactory and calls for designing and implementing intervention measures toward improved animal health in dairy farms and further public health.
Molecular prevalence and associated risk factors of Anaplasma ovis in Pakistani sheep
Authors: Naeem Muhammad , Amaro-Estrada Itzel , Taqadus Asia , Swelum Ayman A. , Alqhtani Abdulmohsen H. , Asif Muhammad , Sajid Muhammad , Khan Asmat Ullah , Tariq Aliza , Anjum Summaya , Khan Adil , Iqbal Furhan
Published: March 2023

Background

Majority of Pakistani population lives in rural areas and raising animals, especially the small ruminants, is their primary source of income. Anaplasma ovis is known to infect small ruminants globally and causing significant economic losses to livestock owners, however prevalence of Anaplasma ovis has been least investigated from Pakistan despite having a huge sheep population.

Methods

The present study was conducted from June 2021 till December 2021 to report the PCR based prevalence of Anaplasma ovis in the blood samples of sheep (n = 239) that were collected from District Dera Ghazi Khan in Pakistan.

Results

Out of 239 samples, 30 (12.5%) amplified a 347 bp fragment specific for the msp4 gene of Anaplasma ovis. Represented partial msp4 gene sequences were confirmed by Sanger sequencing and deposited to GenBank (OP620757-59). None of the studied epidemiological factors (age, sex, breed, size of herd, dogs with herd, and composition of herd) showed an association (P > 0.05) with the Anaplasma ovis infection in enrolled sheep. Analysis of the amplified partial mSP4 sequence of Anaplasma ovis revealed that this gene is highly conserved as all three sequences were identical and phylogenetically resembled with the msp4 sequences amplified from small ruminants in China, Kenya, and Germany, Turkey, Portugal, Tunisia and India. In conclusion, for the first time, we are reporting a moderate prevalence of Anaplasma ovis prevalence in Pakistani sheep and this data will help in developing the integrated control policies against this newly reported tick-borne disease that is infecting our sheep breeds.
A review of important heavy metals toxicity with special emphasis on nephrotoxicity and its management in cattle
Authors: Tahir Ifrah , Alkheraije Khalid Ali
Published: March 2023

Toxicity with heavy metals has proven to be a significant hazard with several health problems linked to it. Heavy metals bioaccumulate in living organisms, pollute the food chain, and possibly threaten the health of animals. Many industries, fertilizers, traffic, automobile, paint, groundwater, and animal feed are sources of contamination of heavy metals. Few metals, such as aluminum (Al), may be eliminated by the elimination processes, but other metals like lead (Pb), arsenic (As), and cadmium (Ca) accumulate in the body and food chain, leading to chronic toxicity in animals. Even if these metals have no biological purpose, their toxic effects are still present in some form that is damaging to the animal body and its appropriate functioning. Cadmium (Cd) and Pb have negative impacts on a number of physiological and biochemical processes when exposed to sub-lethal doses. The nephrotoxic effects of Pb, As, and Cd are well known, and high amounts of naturally occurring environmental metals as well as occupational populations with high exposures have an adverse relationship between kidney damage and toxic metal exposure. Metal toxicity is determined by the absorbed dosage, the route of exposure, and the duration of exposure, whether acute or chronic. This can lead to numerous disorders and can also result in excessive damage due to oxidative stress generated by free radical production. Heavy metals concentration can be decreased through various procedures including bioremediation, pyrolysis, phytoremediation, rhizofiltration, biochar, and thermal process. This review discusses few heavy metals, their toxicity mechanisms, and their health impacts on cattle with special emphasis on the kidneys.