bluuebunny/crossref_metadata_2025 huggingface dataset:
The Moderating Role of Employee Empowerment and Distributive Justice in Transformational Leadership with Its Impact on Organizational Commitment in Islamic Banks at Pakistan
Authors: Din Maaz Ud , Khan Faisal , Kadarningsih Ana , Ali Amjad , Astuti Sih Darmi
Published: November 2019

The basic of the current studywas to discover the influence of transformational leadership on organizational commitment,distributive justice, and employee empowerment as moderate variables in the Islamic banking company of DistrictSwat, KP-Pakistan.Adopted questionnaires were used to have five pointsLikert scalesand containing 24 items. 18 samples were taken with Random Sampling Techniquesfrom the Islamic bank's sector.A total of 305 questionnaires were distributedamong employees and the feedback rate was 80 % which 245questionnaires received.Data analysis used multiple linear regression. The study found thatorganizational commitment is positively and significantly affect empowerment. Distributive justice has a positive influence on organization commitment but not significant. There was also found that the leadership of transformational influences organization commitment positively and significantly.The variance of transformational leadership and organizational commitments were 16% which indicates a weaksignificant influence.
Peramalan Produksi Menggunakan Metode Autoregressive Integrated Moving Average (ARIMA) di PT. XYZ
Authors: Buchori Mohammad , Sukmono Tedjo
Published: November 2019

In production planning and control the first step is to forecast to determine how much production, the company forecasting is still not optimal, because forecasting has an important role in a company. PT. XYZ is a food company that produces chicken meatballs and chicken dumplings. So from that this study uses the forecasting method Autoregressive Integreted Moving Average (ARIMA). ARIMA is often also called the Box-Jenkins time series method. ARIMA is very good for short-term forecasting, while for long-term forecasting the forecasting accuracy is not good. The purpose of this research is to get a good ARIMA model, used to forecast production in the company. So that the production becomes optimal and not excessive which can cause waste of raw materials, which will make production costs a lot. Data processing is done with the help of an Eviews computer program to determine a good ARIMA model, from processing data obtained by ARIMA (1.0,0). With the results obtained forecasting in the period 37 to period 48.
Antibacterial Activity of Rhamnus prinoides extracts against Staphylococcus aureus and Escherichia coli
Authors: GETA KINDU
Published: November 2019

Background: Infectious diseases caused by bacteria have a large impact on public health. Increasing in resistant microbial infections intensified the search for new, safer, and more efficacious agents to combat serious microbial infections. Plants have played a central part in combating many diseases in human and domestic animal in many local communities, including Africa. Rhamnus prinoides is Ethiopian medicinal plants that have been used traditionally for the treatment of diverse infectious diseases. Therefore, this research was carried out to evaluate antibacterial activity Rhamnus prinoides extracts against pathogenic bacteria. Methods: The antimicrobial activity tests were carried out by the agar well diffusion method. Broth dilution and streak plate methods were used to determine MIC and MBC of extracts respectively. Results: The results revealed that ethanol extracts of fruits showed the highest antibacterial activity against standard strains of S.aureus with mean inhibition zone of 26±0.58, 28.33±1.2 and 33.33±0.9mm at 25, 50 and 100mg/ml respectively. The lowest mean MIC value (1.04 mg/ml) was recorded with ethanol extract of fruits against standard strains of S. aureus and the lowest mean MBC value (2.08 mg/ml) was recorded with ethanol extract of fruits against standard strains and clinical isolates of S. aureu. Conclusion: On the basis of the current findings, Rhamnus prinoides could be a good candidate in the search for new antibacterial agents from natural products against bacterial pathogens. Therefore, further studies are needed to study their toxicology and isolate the bio- active components from this plant. Key words: Antibacterial activity, Escherichia coli, MBC, MIC, Rhamnus prinoides, Staphylococcus aureus
Integrally Evaluation of production safety and genotoxicity of recycling residual sludge for drinking water treatment plants
Authors: Yao Meng , chen ting , ran zhilin , wu qibao , Li shaofeng
Published: November 2019

Background: Recycling residual sludge in Drinking Water Treatment Plants could provide numerous benefits, like enhancing pollutant treatment efficiency and saving coagulant dosage. However, residual sludge may release excessive heavy metals and organic matter, some of which are of concern for their toxic and carcinogenic potential. The study was to investigate potential genotoxic, cytotoxic and mutagenic effects of recycled residual sludge to quality of finished water in potable water works. Methods: Based on different biotrophic level, species and genetic end point, multiple test animals and different target cells were screening out to establish a relatively systematic and comprehensive evaluation system of potential genotoxic events. Genotoxic effects of reusing residual sludge were evaluated using a combination of seven different bioassays: Ames test, Sperm abnormality test in mice, micronucleus assay (Zebrafish cell, Mice bone marrow cells and Hamster ovary cells), Comet assay and Single cell gel electrophoresis assay were separately applied to detect gene mutation, chromosome aberration and DAN damage. Result: The results of Ames assay show that the disinfected water sample display bacteriostasis at dose of 7 L/dish regardless of treatment styles, but MR<2 can still be judged as negative. The micronucleus rates of conventional treatment were slightly genotoxic but only at 4 and 40 L/kg·bw, while micronucleus rates of filtered water and disinfectant from recycling process were negative in all dose groups. The levels of DNA damage caused by different treatment processes were substantially equivalent. Conclusion: Reusing residual sludge for DWTP did not contribute to the release of genotoxic or mutagenic compounds, while had remarkable effect on saving drug dose and increasing drinking water yield, which should be widely recommended.
FGF21 Attenuates Neurodegeneration though Reducing Neuroinflammation and Oxidant-stress
Authors: Kang Kai , Xu Pengfei , Wang Mengxia , Chunyu Jian , Sun Xu , Ren Guiping , li deshan
Published: November 2019

Background It is reported that FGF21 can repair the nerve injury, but the specific mechanism is less studied. The present study was designed to investigate the effects and possible mechanisms of FGF21 on neurodegeneration of the aging in 20 month old C57BL/6 mice and the diabetes in C57BL/ksj -db/db mice which were susceptible to Alzheimer’s disease (AD). Methods The db/db mice and aging mice were used to verify the effects and possible mechanisms of FGF21 on neurodegeneration. These mice was processed with PBS, FGF21 or metformin once daily for several months. The related indicators of neurodegeneration were assessed by Quantitative Real Time-PCR, western blot and others.Results There were loss of nerve cells and intracellular edema around hippocampus in db/db mice and aging mice which were inhibited by FGF21. In vivo investigation revealed that the procession of FGF21 led to suppress the aggregation of Tau and β-Amyloid1-42 which led to apoptosis in nerve cells. Meanwhile, FGF21 significantly decreased the expression of NF-κB, IL6 and IL8 (p<0.05) and increased anti-oxidant enzymes (p<0.05) in db/db mice. In addition, the phosphorylation of AKT and AMPKα were increased by FGF21 in db/db mice, which were considered as anti-inflammation and anti-oxidant stress pathway. The related indicators of neurodegeneration were also exhibited in aging mice which showed similar trends. The vitro experiment showed that the aggregation of Tau and β-Amyloid1-42 were increased by LPS, and hyperaggregation of Tau and β-Amyloid1-42 were inhibited by FGF21 in SHSY-5Y cells. Conclusion It was concluded that FGF21 attenuated neurodegeneration by reducing neuroinflammation and oxidant stress though regulating the NF-κB pathway and AMPK pathway which enhanced the protective effect of mitochondria on nerve cells.
Trophic niche differentiation mirrors intra-island population structure of Galápagos marine iguanas (Amblyrhynchus cristatus)
Authors: Anslan Sten , Reinhardt Timm , Fink Patrick , Brauns Mario , Peñafiel Nicolás , Guayasamin Juan M. , Páez-Rosas Diego , Vences Miguel , Steinfartz Sebastian
Published: November 2019

Background: Differences in the trophic niche often underlie ecological specialization of individuals and can promote ecological speciation of populations, but studies showing a link between differences in the trophic niche and genetic differentiation of populations are rare. On the island of San Cristóbal (Galapágos archipelago), a strong genetic differentiation between two relatively proximate populations (subspecies; Amblyrhynchus cristatus mertensi and A. c. godzilla) of marine iguanas along the coastline has been observed. Here, we explore whether this genetic differentiation is mirrored in the iguanas’ trophic niche. Results: Although, no significant difference in the number of consumed algal taxa between subspecies were detected, the Schoener index exhibited low diet overlap between A. c. mertensi and A. c. godzilla. The latter was also demonstrated by the PERMANOVA analysis with significantly different diet OTU composition from the fecal samples between subspecies. Stable isotope analysis revealed that subspecies identity was overall more important than site for the iguanas’ resource use. Conclusions: By applying a metabarcoding approach on feces samples in combination with stable isotope analysis of skin sheds, we found that A. c. mertensi and A. c. godzilla differ in their ecological niches. Moreover, stable isotope analysis indicated that marine iguana populations have low spatial foraging distances, which, together with the diet partitioning patterns, might explain, at least partially, the lack of gene flow between these geographically proximate marine iguana populations. Key words: diet analysis, trophic niche, metabarcoding, stable isotopes, marine iguanas, Amblyrhynchus cristatus
Preoperative dipyridamole-thallium scanning did not reduce 90-day cardiac complications and mortality in patients with femoral neck fractures undergoing hemiarthroplasty
Authors: Liao Chin-Yi , Tan Timothy L , Lu Yu-Der , Wu Cheng-Ta , Lee Mel S , Kuo Feng-Chih
Published: November 2019

Background: Patients with hip fractures have risk factors that increase the likelihood of postoperative cardiac complications and mortality. This study aimed to evaluate the effect of dipyridamole-thallium scanning on 90-day cardiac complications and mortality in patients with femoral neck fracture treated with hemiarthroplasty. Methods: Between 2008 and 2015, 844 consecutive patients undergoing cemented or cementless hemiarthroplasty were identified from the database of a single level-one medical center. One-hundred and thirteen patients (13.4%) underwent the dipyridamole-thallium scan test prior to surgery, and 731 patients (86.6%) did not. Patient characteristics, comorbidities, surgical variables, and duration to surgery were recorded. Multivariate logistic regression was performed, and a propensity-score-matched cohort was identified in order to determine whether dipyridamole-thallium scanning was associated with 90-day cardiac complications and mortality.Results: The incidence of 90-day cardiac complications was 19.47% in the thallium scan group and 11.58% in the non-thallium scan group (p = 0.343) among 452 patients after propensity score-matching. The 90-day mortality rate was similar in the two groups (0.88% vs. 1.18%, p = 0.795). In the propensity score-matched patients, utilization of the dipyridamole-thallium scan was not associated with cardiac complications (matched cohort, adjusted odds ratio [OR] = 1.32; 95% confidence interval [CI] 0.75 to 2.33) or mortality (adjusted OR = 0.75; 95% CI 0.08 to 6.71) within 90 days. Risk factors for cardiac complications were an American Society of Anesthesiologists grade 3 (OR 3.19, 95% CI 1.44 to 7.08) and pre-existing cardiac comorbidities (OR 5.56, 95% CI 3.35 to 9.25). Discussion: Preoperative dipyridamole-thallium scanning was not associated with reductions in 90-day cardiac complications and mortality in patients with femoral neck fracture undergoing hemiarthroplasty. The necessity for dipyridamole-thallium scanning should be re-evaluated in elderly patients with femoral neck fractures, given that this increases the duration to surgery.
Clinical features and influencing prognostic factors in patients with anti-NMDAR encephalitis: a cohort follow-up study in Chinese patients
Authors: Wang Yingxin , Miao Ailiang , Shi Yongwei , Ge Jianqing , Wang Lingling , Xu Haiyan , Yu Chuanyong , Yu Yuanwen , Huang Shuyang , Jiang Wenwen , Li Yihan , Wang Xiaoshan
Published: November 2019

Objectives The clinical manifestations of patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis in East China and factors associated with prognosis were analyzed.Methods A retrospective study of 106 patients (58 females; 48 males) with anti-NMDAR encephalitis in East China was carried out from June 2015 to February 2019. Clinical features and factors influencing outcomes were reviewed.Results Behavioral changes were observed in 74.5% (79/106) of patients, and comprised the initial symptoms in 61.3% (65/106). Seizures were observed in 67% (71/106) of patients, and served as initial symptoms in 31.1% (33/106). A total of 54.9% (39/71) of seizures were focal seizures. More clinical symptoms were observed in female patients than in male patients ( P =0.000). Similarly, background activity (BA) with cerebrospinal fluid (CSF) antibody titers at the peak stage was more severe in female patients than in male patients ( P = 0.000). The Binary logistic regression and ROC curve analyses revealed the factors associated with poor outcomes included consciousness disturbance (OR: 4.907, 95% CI: 1.653-14.562, P =0.004; area: 65.4%, sensitivity: 44.2%, specificity: 86.5%, P =0.014 ), EEG BA (OR: 3.743, 95% CI: 1.766-7.932, P =0.001; area: 76.6%, sensitivity: 73%, specificity: 75%, P =0.000), number of symptoms (OR: 2.911, 95% CI: 1.811-4.679, P =0.000; area: 77.1%, sensitivity: 59.5%, specificity: 78.6%, P =0.000) and CSF antibody titer (OR: 31.778, 95% CI: 8.891-113.57, P =0.000; area: 83.9%, sensitivity: 89.2%, specificity: 78.6%, P =0.000).Conclusions EEG BA and number of symptoms were associated with CSF antibody titers. Consciousness disturbances, EEG BA, number of symptoms and CSF antibody titers served as predictors of poor outcomes.
Time‐Lapse Cameras for Measurement of Grain Corn Phenology on the Canadian Prairies
Authors: Zhanda Justice , Bullock Paul R. , Zvomuya Francis , Shaykewich Carl , Reid Lana M. , Lawley Yvonne , Flaten Don
Published: November 2019

Core Ideas

Time‐lapse cameras provided accurate grain corn development dates to V6 and for VT and R1.

Grain corn hybrids all accumulated more corn heat unit (CHU) to R6 than indicated by their CHU ratings.

The general thermal index may be more accurate than CHU for modeling grain corn phenology from temperature.

Shorter season grain corn (Zea mays L.) varieties and increased heat unit accumulation are improving grain corn production feasibility on the Canadian Prairies. However, there remains significant production risk and need for a reliable measure of corn heat requirements for risk assessment. This study utilized time‐lapse cameras to capture phenological development of five grain corn hybrids with corn heat unit (CHU) ratings from 2200 to 2700 at multiple locations in western Canada. The goal was to compare heat unit accumulation at specific phenological stages at multiple locations to identify an index with consistent accumulated values. The photos provided a clear record of development up to the V6 stage and for the VT and R1 stages. This facilitated accurate quantification of accumulated days after planting (DAP), CHU, standard growing degree day (GDD10), modified growing degree day (mGDD10,30), general thermal index (GTI), and beta function (BFn) for the five hybrids. All hybrids accumulated more CHU to reach R6 stage than suggested by their ratings. The coefficient of variation (CV) for accumulated index values was greatest at emergence and the V2 stage but declined in subsequent stages. At R6, all thermal indices had a CV ≤ 10.5%, with GTI consistently showing the numerically lowest CV (<5%) for all hybrids. The GTI may be a more consistent thermal index than CHU for predicting corn phenological development and an important improvement for selecting appropriate grain corn hybrids for specific locations on the Canadian Prairies. Further time‐lapse camera data is warranted to confirm these observations.
Organo or Metal Complex Catalyzed Synthesis of Five-membered Oxygen Heterocycles
Authors: Kaur Navjeet , Ahlawat Neha , Grewal Pooja , Bhardwaj Pranshu , Verma Yamini
Published: November 2019

:

The reactions involving the formation of C-O bond using metal as a catalyst have emerged to be one of the most influential reactions for the synthesis of heterocycles in modern organic chemistry. Catalysis by metals offers diverse opportunities to invent new organic reactions with a promising range of selectivities such as chemoselectivity, regioselectivity, diastereoselectivity, and enantioselectivity. The methodologies used earlier for synthesis were less approachable to the organic chemist because of their high cost, highly specified instrumentation and inconvenient methods. For both stereoselective and regioselective formation of five-membered O-containing heterocycles, cyclic reactions that are metal and non-metal-catalyzed have known to be very efficient. The present review article covers the applications of metal and non-metal as a catalyst for the synthesis of five-membered O-containing heterocycles.
Synthesis of Substituted imidazo [1, 5-a] pyrimidine-2-(1H)-one Core Structure
Authors: Kalhapure Vijay , Magar Dhananjay , Kothalkar Nishant , Khaladkar Tushar , Roychowdhury Abhijit
Published: November 2019

Background and Objective:

The objective of our work was to establish a facile and scalable
synthesis of imidazopyridone for further use in medicinal chemistry applications. An easy synthesis of a core
scaffold will enable the medicinal chemistry community to use imidazopyridone as a privileged scaffold in new
chemical entity (NCE) synthesis.

Materials and Methods:

The synthesis was achieved from commercially available and cheap raw materials
like amino acetonitrile hydrochloride or commercially available guanidine.

Results:

Simple transformation starting from amino acetonitrile hydrochloride leads to the synthesis of a
versatile imidazo [1, 5-a] pyrimidine-2-(1H)-one core structure. Using suitable functionalized starting
materials, a set of NCEs were synthesized to demonstrate the application of the developed synthetic scheme.
Similarly, guanidine was also used to synthesize a regioisomer of imidazopyridone in moderate to good yields.

Conclusion:

We demonstrate the synthesis of two different regio-isomers of imidazopyrimidinone using
simple chemical transformations. Its application in synthesizing NCEs has also been exhibited in the present
work.
Stinging Insect Allergens
Authors: Cui Le , Xu Ying-Yang , Wang Xiu-Jie , Guan Kai
Published: November 2019

Hymenoptera venom allergy is one of the common causes of anaphylaxis. However, when physicians make the diagnosis of Hymenoptera venom allergy, the history of being stung is not always consistent with the results of venom-specific IgE. With the development of component-resolved diagnosis, it is possible to accurately localize an allergic reaction to certain sensitized proteins. This paper reviewed the studies that have addressed the identified allergenicity and cross-reactivity of Hymenoptera venom allergens accepted by the WHO/IUIS Nomenclature Sub-committee, the componentresolved diagnosis of Hymenoptera venom allergy and its predictive values for the efficacy and safety of venom immunotherapy. Also special attention was paid to the spread of Hymenoptera venom allergy in Asian countries.
Carbonaceous Nanomaterials-Mediated Defense Against Oxidative Stress
Authors: Forbot Natalia , Bolibok Paulina , Wiśniewski Marek , Roszek Katarzyna
Published: November 2019

:

The concept of nanoscale materials and their applications in industrial technologies, consumer
goods, as well as in novel medical therapies has rapidly escalated in the last several years. Consequently,
there is a critical need to understand the mechanisms that drive nanomaterials biocompatibility
or toxicity to human cells and tissues.

:

The ability of nanomaterials to initiate cellular pathways resulting in oxidative stress has emerged as a
leading hypothesis in nanotoxicology. Nevertheless, there are a few examples revealing another face of
nanomaterials - they can alleviate oxidative stress via decreasing the level of reactive oxygen species.
The fundamental structural and physicochemical properties of carbonaceous nanomaterials that govern
these anti-oxidative effects are discussed in this article. The signaling pathways influenced by these
unique nanomaterials, as well as examples of their applications in the biomedical field, e.g. cell culture,
cell-based therapies or drug delivery, are presented. We anticipate this emerging knowledge of
intrinsic anti-oxidative properties of carbon nanomaterials to facilitate the use of tailored nanoparticles
in vivo.
ADCs, as Novel Revolutionary Weapons for Providing a Step Forward in Targeted Therapy of Malignancies
Authors: Amani Nooshafarin , Dorkoosh Farid Abedin , Mobedi Hamid
Published: November 2019

:

Antibody drug conjugates (ADCs), as potent pharmaceutical trojan horses for cancer treatment, provide superior efficacy and specific targeting along with low risk of adverse reactions compared to traditional chemotherapeutics. In fact, the development of these agents combines the selective targeting capability of monoclonal antibody (mAb) with high cytotoxicity of chemotherapeutics for controlling the neoplastic mass growth. Different ADCs (more than 60 ADCs) in preclinical and clinical trials were introduced in this novel pharmaceutical field. Various design-based factors must be taken into account for improving the functionality of ADC technology, including selection of appropriate target antigen and high binding affinity of fragment (miniaturized ADCs) or full mAbs (preferentially use of humanized or fully human antibodies compared to murine and chimeric ones), use of bispecific antibodies for dual targeting effect, linker engineering and conjugation method efficacy to obtain more controlled drug to antibody ratio (DAR). Challenging issues affecting therapeutic efficacy and safety of ADCs, including bystander effect, on- and off-target toxicities, multi drug resistance (MDR) are also addressed. 4 FDA-approved ADCs in the market, including ADCETRIS ®, MYLOTARG®, BESPONSA ®, KADCYLA®. The goal of the current review is to evaluate the key parameters affecting ADCs development.
Atomic Force Microscopy: The Characterisation of Amyloid Protein Structure in Pathology
Authors: Visser Maria J.E. , Pretorius Etheresia
Published: November 2019

:

Proteins are versatile macromolecules that perform a variety of functions and participate in
virtually all cellular processes. The functionality of a protein greatly depends on its structure and alterations
may result in the development of diseases. Most well-known of these are protein misfolding disorders,
which include Alzheimer’s and Parkinson’s diseases as well as type 2 diabetes mellitus, where
soluble proteins transition into insoluble amyloid fibrils. Atomic Force Microscopy (AFM) is capable of
providing a topographical map of the protein and/or its aggregates, as well as probing the nanomechanical
properties of a sample. Moreover, AFM requires relatively simple sample preparation, which presents
the possibility of combining this technique with other research modalities, such as confocal laser
scanning microscopy, Raman spectroscopy and stimulated emission depletion microscopy. In this review,
the basic principles of AFM are discussed, followed by a brief overview of how it has been applied
in biological research. Finally, we focus specifically on its use as a characterisation method to
study protein structure at the nanoscale in pathophysiological conditions, considering both molecules
implicated in disease pathogenesis and the plasma protein fibrinogen. In conclusion, AFM is a userfriendly
tool that supplies multi-parametric data, rendering it a most valuable technique.
Dickkopf-1 and β-catenin as Biomarkers for Early Diagnosis of Hepatocellular Carcinoma
Authors: Mohamed Amal A. , Ghanem Hala M. , Kamal Maha M. , Ahmed Rehab , Madkour Naglaa K. , Abdou Dina , Talima Soha M. , Hawash Nehad , Abd-Elsalam Sherief
Published: November 2019

Background &Aims:

The clinical value of alpha-fetoprotein (AFP) as a marker to
detect early hepatocellular carcinoma (HCC) has been questioned owing to its low sensitivity and
specificity. The purpose of this work was to investigate whether serum Wnt/β-catenin and DKK1
levels in chronic hepatitis C patients could be used as early predictors for the risk of HCC
development.

Methods:

The study was conducted on 37 healthy controls, and 150 CHC patients were divided
into three groups: CHC, liver cirrhosis (LC), and HCC patients. AFP, AFP-L3, β-catenin, and
DKK-1 were assayed by ELISA.

Results:

Both β-catenin and DKK1 levels significantly increased (p < 0.001) in the HCC group in
comparison to LC and CHC groups. The first cut-off value for DKK-1 was 253 pg/ml with 88%
sensitivity and 86% specificity. The second was 301.5 pg/ml with 82 percent sensitivity and
100% specificity. The β-catenin cut-off value was 7.35 ng/ml with 80% sensitivity and 74%
specificity. A positive correlation was observed between DKK-1 and β-catenin (r=0.491), DKK-1
and tumor size (r =0.616), and β-catenin and tumor size (r =0.472).

Conclusion:

DKK-1 and β-catenin may serve as predictors for the progression of CHC and LC
into HCC.
Patient Education and Engagement through Social Media
Authors: Chirumamilla Sravya , Gulati Martha
Published: November 2019

:

This review addresses the demographics of social media users and their relative health
literacy. Means of overcoming health inequities via social media and the role of social media in patient
education and engagement are explored. This review discusses forms of appropriate patient
engagement, including the pitfalls of social media use.
Different Medical Image Registration Techniques: A Comparative Analysis
Authors: Karthick Suyambu , Maniraj S.
Published: November 2019

Background:

Image registration provides major role in real world applications and classic
digital image processing. Image registration is carried out for more than one image and this image
was captured from a different location, different sensors, different time and different viewpoints.

Discussion:

This paper deals with the comparative analysis of various registration techniques and
here six registration techniques depending upon intensity, phase correlation, image feature, area,
control points and mutual information are compared. Comparative analysis for different methodologies
shows the advantages of one method over the other methods. The foremost objective of this
paper is to deliver a complete reference source for the scholars interested in registration, irrespective
of specific application extents.

Conclusion:

Finally performance analyses are evaluated for the medical datasets and comparison is
graphically shown with the MATLAB simulation tool.
Chiral Separation of Oxomemazine Enantiomers by HPLC Technique and Enantiomeric Separation Mechanism via Docking Studies
Authors: Raikar Prachi , Gurupadayya Bannimath , Mandal Subhankar P. , Reddy Maruthi , Prabhakar Prabitha
Published: November 2019

Background:

A normal phase- High Performance Liquid Chromatographic (HPLC) method
was developed for the enantioseparation of Oxomemazine.

Methods:

Separation of enantiomers was attained on Amylose Tris (5-chloro-2-methylphenylcarbamate)
using n-hexane: Iso-propyl Alcohol (IPA): Diethylamine (DEA) (60: 40: 0.1) as the
mobile phase and the peaks were observed at 227nm using PDA detector. The run time of the analysis
was set to 30 min.

Results:

Linearity was found in the range 10-50 μgmL-1. The enantiomers were separated at retention
times 16.87 min and 21.37 min.

Conclusion:

The developed method was validated as per the ICH guidelines, thus proving the method
to be selective, precise and showing linear response of Oxomemazine peak areas. Additionally, the
method of chiral separation was being understood by docking simulation study. The method was appropriate
for analysis of Oxomemazine in the pure form and its formulation.
Sleep and Sleep Disorders in Tourette Syndrome: What is Known and What is Still Unknown
Authors: Oksenberg Arie
Published: November 2019

Background:

Most of the patients with Tourette Syndrome (TS) present additional comorbidities. Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive-Compulsive Disorder (OCD) are the most common. Sleep Disorder has been suggested also as common comorbidity.

Objective:

To review the literature on sleep characteristics and sleep disorder in patients with Tourette Syndrome (TS), with emphasis on the contribution of specific co-morbidities to the severity of impaired sleep and life quality of the patients.

Results:

In general, sleep problems are not frequent at the age when tics appear which are estimated to affect about 10 % of these children. In severe cases, tics appear in all sleep stages. In a large study, the prevalence of sleep problems was 17.8% but was 12 % in “TS-only” (9.4% in children and 7.5 in adults) compared to 22% in children and 18% in adults with TS+ADHD. Unfortunately, in most of the studies, the characteristics of these “sleep problems” are not defined. In spite of the scarcity of data, the two main sleep disorders in TS patients are insomnia and parasomnias. Although much more data is needed, many TS subjects are sleep deprived (which exacerbate the tics) and may suffer from excessive daytime sleepiness, which negatively affects normal functioning.

Conclusions:

Although the literature is not conclusive, children and adolescents with TS appear to suffer more from sleep disturbances and sleep disorders than age-matched controls. Not all patients have tics during sleep, but in severe cases, tics may appear in all sleep stages. It is clear that when patients present both TS and ADHD, (a very common condition), the sleep difficulties are related mainly to ADHD. Much more research is warranted in all aspects of sleep and sleep disorders in TS.
Design, Synthesis and Evaluation of Novel Substituted (5-methyl-1H-pyrazol-3-yl)- 1,3,4-oxadiazole as Potent Androgen Receptor Antagonist
Authors: Andavar Sasikumar , Vaithilingam Mohanasrinivasan , Selvaraj Divakar , Kumaran Ajeeshkumar A. , Devanathan Krishnaswamy
Published: November 2019

Background:

Androgen Receptor (AR) is one of the highly explored targets for the treatment of
prostate cancer. The emergence of point mutation in the Ligand Binding Domain (LBD) of AR has resulted in
the development of resistance against AR antagonist. The point mutation T877A, W741L and F876L confer
resistance to flutamide, bicalutamide and enzalutamide respectively. There is no AR antagonist in the present
clinical set up without resistance. Hence, our aim in this study is to design a novel molecule to overcome the
resistance caused by point mutation.

Methods:

Here, we developed novel AR antagonist bearing (5-methyl-1H-pyrazol-3-yl)-1, 3,4-oxadiazole core
by rational drug design. The test molecules 8a-h were synthesized from the corresponding dihydrazide compounds
7a-h on treatment with phosphorous oxychloride on reflux conditions. The structure of the molecules
was confirmed from spectral data such as IR, 1H-NMR, HRMS and 13C-NMR. The synthesized compounds were
screened for cytotoxicity in prostate cancer cell lines LNCaP-FGC and PC3. The confirmation of AR mediated
activity of the test compounds was confirmed by gene expression study. The interaction of the best active
ligands with mutant AR was predicted and drug design was rationalized through docking studies.

Results:

The test compounds 8a-h were synthesized and the structures were conformed using suitable techniques
like IR, 1H-NMR, HRMS and 13C-NMR. Among the tested compounds, 8b and 8d showed potent antiproliferative
activity against mutant AR cell lines. Further, these compounds significantly decreased the gene
expression of prostate cancer biomarkers.

Conclusion:

In this study, we have identified a potential hit molecule for AR antagonism that could be further
developed to obtain a potent clinical candidate.
Response Surface Methodology Towards Optimization of Calotropis Procera Essential Oil Extraction by Using Supercritical CO2
Authors: Zaeri Hossein , Moghadas Bahareh Kamyab , Honarvar Bijan , Rad Ali Shokuhi
Published: November 2019

Aim:

In this research, we aim to investigation on the extraction of essential oil from Calotropis Procera with the family name of Asclepiadaceae, by supercritical carbon dioxide (CO2) solvent.

Objective:

The comparison of the yield and chemical profile of the extracts achieved by this method with those resulted by the conventional Hydro distillation method.

Methods:

The extraction experiments were carried out in a bench-scale SC-CO2unit. The effects of temperature, pressure, and extraction time on the oil yield are considered for investigation. The Response Surface Methodology (RSM) with Central Composite Design (CCD) was employed to optimize the process parameters of CO2supercritical extraction (SCE) of the Calotropis Procera. In this experimental design, the design was required 19 experiments with eight (23) factorial points and five replications of the center.

Results:

Results showed that the data were sufficiently fitted into the second-order polynomial model. The extraction conditions, including pressure, temperature, and extraction time, were studied between 150-200 bar, 40-50 ºC, and 50-100 min, respectively.

Conclusion:

The optimal conditions are achieved as the temperature of 47.19ºC, the pressure of 172.2 bar, and time of 86 minutes with the retrieval rate of 31.39%.
Elucidation of the regulation mechanism of cartilage differentiation of physiologically active peptide derived from collagen
Authors: Nakatani Sachie
Published: November 2019

In Japan, there is a system in place called 'Foods with Function Claims'. This system basically requires that if a food company wants to make a claim about the specific benefits of a foodstuff, it must be supported by scientific evidence. This is an important initiative for a wide variety
of reasons. For instance, people taking foodstuffs that are not supported by scientific evidence might well decide not to take supplements with genuine benefits because they believe they are already taking adequate steps. To comply with the 'Foods with Function Claims' system, companies rely
on the work of researchers to determine whether what they are claiming is supported by scientific evidence. Dr Sachie Nakatani leads a team based at Josai University in Japan, which is investigating a wide range of different foodstuffs to determine whether they have genuine health benefits.
International research delivers many rewards
Authors: Sharp Lucy
Published: November 2019

International collaboration in research is not a new concept, but as pressure on research funding increases, project applications for funding must deliver a comprehensive package of well-considered experimental design, impactful research focus and a world-class team. Collaborations
with key international leaders in their fields are an excellent way of boosting the credentials of any project, increasing the chances of the group getting funding by opening up their pool of potential funders.
Exploring the Determinants of Mobile Health Adoption by Hospitals in China: Empirical Study
Authors: Ramdani Boumediene , Duan Binheng , Berrou Ilhem
Published: November 2019

Background

Although mobile health (mHealth) has the potential to transform health care by delivering better outcomes at a much lower cost than traditional health care services, little is known about mHealth adoption by hospitals.

Objective

This study aims to explore the determinants of mHealth adoption by hospitals using the technology-organization-environment (TOE) framework.

Methods

We conducted an interviewer-administered survey with 87 managers in Chinese public hospitals and analyzed the data using logistic regression.

Results

The results of our survey indicate that perceived ease of use (β=.692; P<.002), system security (β=.473; P<.05), top management support (β=1.466; P<.002), hospital size (β=1.069; P<.004), and external pressure (β=.703; P<.005) are significantly related to hospitals’ adoption of mHealth. However, information technology infrastructure (β=.574; P<.02), system reliability (β=−1.291; P<.01), and government policy (β=2.010; P<.04) are significant but negatively related to hospitals’ adoption of mHealth.

Conclusions

We found that TOE model works in the context of mHealth adoption by hospitals. In addition to technological predictors, organizational and environmental predictors are critical for explaining mHealth adoption by Chinese hospitals.
Daily Patronage Politics: A Village Chief’s Route to Power
Authors: Cahyati Devy Dhian , Luter Lopo Yonatan Hans
Published: November 2019

This article discusses the politics of  patronage used by incumbents in contesting village chief elections. Through observations and interviews conducted before and after the 2018 village chief  elections in Klangor Village, Galur District, Kulon Progo Regency, the researchers explored the strategies used by the incumbent to contest the election and seek re-election. At the village level, the politics of  patronage function differently than at higher levels of  government. The authors argue that incumbents do not only create patronage networks during elections, during which voters are provide money or other gifts; they create patronage networks during their everyday activities. Using the economic resources available to them, incumbents combine three approaches to patronage: benevolence politics, scare-off tactics, and money politics. In this article, the authors argue that the incumbent redefined money, transforming it from a means of  conducting transactions into a means of  appreciating and rewarding voters. By using this strategy, incumbents can guarantee supporters’ loyalty and receive their votes.
Cuidado perdido de enfermería. Estado del arte para la gestión de los servicios de salud
Authors: Zárate-Grajales R.A. , Mejías M.
Published: November 2019

El cuidado perdido de enfermería es un fenómeno recientemente explorado que afecta la seguridad de los pacientes, la calidad de la atención y cuestiona la actuación de los profesionales de enfermería.

Objetivo: Conocer el Estado del Arte del tema Cuidado perdido en Enfermería a partir de artículos publicados durante el periodo marzo 2012- marzo 2018.

Metodología: Se realizó una investigación documental a través del sistema de búsqueda PUBMED, con las siguientes palabras clave: missed nursing care, misscare AND care nurse. Se seleccionaron 47 artículos de investigación en idioma inglés y español. Posterior al análisis de contenido de los artículos, los resultados se agruparon en categorías.

Resultados: Se identificaron las siguientes categorías: país donde se realizó la investigación, unidades de atención, tipo de estudio, muestra estudiada, instrumento empleado, marco conceptual, así como los elementos, razones y predictores del cuidado perdido.

Conclusiones: El estudio del fenómeno puede ser un insumo para la toma de decisiones en políticas de salud y en el diseño de estrategias e intervenciones que contribuyan a la mejora del cuidado en las instituciones de salud. La revisión del fenómeno y el análisis permitirán a los interesados en el tema, profundizar en el cuidado perdido e identificar la fundamentación teórica, los elementos conceptuales y los resultados encontrados, los cuales serán aportes para la toma de decisiones en los procesos de mejora, la docencia, el cuidado y la investigación.
4D-Structural Dynamics of the Transition State: Free Molecules, Clusters and Nanocrystals
Authors: Aseyev Sergei A. , Ischenko Anatoly A. , Kochikov Igor V. , Mironov Boris N. , Ryabov Evgeny A. , Zhabanov Yury A. , Kompanets Victor O. , Malinovskii Aleksandr L. , Otlyotov Arseniy A. , Chekalin Sergei V.
Published: November 2019

Study of the structural dynamics of matter by methods with high spatially-temporal resolution represents new direction in modern science and provides the understanding of relationship inside the "structure – dynamics – property" triad in the field of physics, chemistry, biology and materials science. Application of femto and attosecond laser pulses for excitation and formation of synchronized ultrashort photoelectron bunches for probing makes it possible to observe coherent dynamics of nuclei and electrons in samples on necessary space-time scales. Using laser spectroscopy one can determine energy levels of the sample and trace their evolution over time. However, the extraction of the structural dynamics of matter from this information is achieved by indirect methods. In the paper authors demonstrate the direct approaches to the study of the coherent dynamics of the nuclei of laser-excited matter in the space-time continuum (4D), based on probing the object with ultra-short electron or X-ray pulses, and describe their experiments, which were carried out using ultrafast electron diffractometer and transmission electron microscope at the Institute of Spectroscopy RAS.
Coaching leadership and subordinates' career success: The mediating role of leader–member exchange.
Authors: Peng Zhenglong , Gao Bo , Zhao Hongdan
Published: November 2019

Although a coaching leadership style has an inherent advantage in predicting the subordinates' career success, there is still little known about the linkage and the specific process by which coaching leadership influences career success. We examined the relationship between coaching
leadership and subordinates' career success, especially the mediating role of leader–member exchange (LMX), through a survey conducted with 301 supervisor–subordinate pairs of a large state-owned enterprise in Shanghai, China. Using Hayes' PROCESS macro, we conducted a Sobel test
and bootstrapping to test our hypotheses. As predicted, we found that coaching leadership was positively related to both subjective and objective career success of subordinates. In addition, LMX mediated the influence of coaching leadership on career success of subordinates. Our findings provide
a new theoretical perspective for explaining the impact of coaching leadership.
Kindergarten teachers' work stress and work-related well-being: A moderated mediation model
Authors: Li You , Zhang Ren-Cheng
Published: November 2019

In this study, 615 kindergarten teacher participants completed a survey comprising teacher work stress, psychological capital, social support, and work-related well-being questionnaires. Results showed that participants' occupational stress not only directly affected their work-related
well-being, but their work-related well-being was also affected through the mediating role of psychological capital. The level of participants' social support also moderated the relationship between their psychological capital and work-related well-being. Results have practical implications
for kindergarten teachers in mainland China such that they can be enlightened on how to avoid a stressful work environment, embrace work-related physical and mental well-being, and maintain their psychological capital.
MAKNA DAN TRADISI-TRADISI DALAM RANGKAIAN TRADISI KHATAM QURAN ANAK-ANAK DI NAGARI BALAI GURAH SUMATERA BARAT
Authors: Wirdanengsih Wirdanengsih
Published: November 2019

This article tries to reveal the analysis of cultural and educational value on the traditions of Khatam Quran children at village Balai Gurah Agam district of West Sumatra. In addition this paper also reveals the meaning of the tradition for the Balai Gurah community . The observation, in-depth interviews and the review of date secondary.. The results of this study found that the tradition of Khatam Quran in villages of Balai Gurah is one of the traditions that express the religious culture of Minangkabau society. For the people of Balai Gurah, tradition Khatam Quran is an initiation process in children and a form of gratitude for the intelligence of children in reading the Quran. Tradition Khatam Quran also has significance awareness in social relationships between people, especially in building unity and mutual assistance among relatives and the community. Tradition Khatam Quran also have the meaning of economic, religius and socio-cultural for the community, In A series of Khatam Quran ceremony is gathered some traditions such as the tradition of musyawarah mufakaik , traditin of makan bajamba , tradition of Mandabiah Jawi, tradition of Talempong music , the tradition of arak-arakan and tradition manyumbang. All that has the meanings.
PENCEGAHAN KEKERASAN DALAM RUMAH TANGGA (KDRT) MELALUI KONSEP HAK DAN KEWAJIBAN SUAMI ISTERI DALAM ISLAM
Authors: Muslim Muslim
Published: November 2019

Domestic violence is a disease in people's lives and is the responsibility of the government to handle it. The PKDRT Law was issued to deal with domestic violence issues, but in reality the PKDRT Law has not been able to resolve this problem completely. What is the cause of domestic violence in the community is apparently caused by the character of the community and this character is strongly influenced by the perception of husband and wife about the rights and obligations of husband and wife in navigating the household. The cause of domestic violence is more because they feel each party feels they have rights that must be fulfilled by the other party, while the other party may feel it is not their obligation. This happens because in understanding rights and obligations there is diversity so that it causes disagreement that can lead to disputes and violence. Religion is a guide to human life, about the rights and obligations of husband and wife already have concepts in fiqh
INTEGRATIVE SCIENTIFIC MADRASAH IN INDONESIA: New Developments in Integrating Science and Religion in the Learning Processes
Authors: ZUHAIDA ANGGUN
Published: November 2019

Science and religion are a unity. The difference between the two lies only in the way of view. Knowledge comes from the One God. All kinds of approaches to reality are ultimately capable of being integrated and integrated with the contemplation of the concept of God's oneness. Scientific activity is closely related to the implementation of education. The implementation of education is always based on curriculum development. The existence of curriculum development is based on the emergence of future challenges and competencies. This research aims to describe the design of integrative science and religion in the device and the implementation of learning. The research method used is descriptive qualitative, sample in this research is teacher at MTsN Kota Salatiga. The integration of science and religion is seen only in the implementation of learning, where teachers have introduced the relationship of science and religion through connecting with the verses of the Qur'an. The integration that has been implemented in the madrasah is already on the operational level.