bluuebunny/crossref_metadata_2025 huggingface dataset:
Depressive Symptoms and Its Associated Factors in 13-Year-Old Urban Adolescents
Authors: Bulhões Cláudia , Ramos Elisabete , Lindert Jutta , Dias Sónia , Barros Henrique
Published: October 2013

The available estimates reveal that 20–50% of adolescents report depressive symptoms, being one of the most prevalent health problems in adolescence. The aim of this study was to assess the prevalence of depressive symptoms in a community sample of 13-year-old adolescents and identify associated features. Thirteen year-old adolescents attending private and public schools in Porto (n = 1,988, 52.2% females) were evaluated from October 2003 to June 2004 and completed a questionnaire including health behaviors and the Beck Depression Inventory II. A questionnaire on parents’ socio-demographics and clinical characteristics was sent home. Data were analyzed separately by sex. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression. The prevalence of depressive symptoms was 18.8% in girls and 7.6% in boys (p < 0.001). Boys with a family history of depression and girls with smoking habits had a significantly increased risk of depressive symptoms (OR = 2.18, 95%CI 1.00–4.71; OR = 2.34, 95%CI 1.46–3.76). Menarche at an early age significantly increased the risk of depressive symptoms. The characteristics most strongly associated with depressive symptoms were family history of depression among boys, tobacco consumption and an early age at menarche among girls. The high prevalence of depressive symptoms early in adolescence calls for the awareness of public health professionals.
Transcriptional Regulation of a Chitinase Gene by 20-Hydroxyecdysone and Starvation in the Oriental Fruit Fly, Bactrocera dorsalis
Authors: Yang Wen-Jia , Xu Kang-Kang , Zhang Rui-Ying , Dou Wei , Wang Jin-Jun
Published: October 2013

Insect chitinases are hydrolytic enzymes that are required for the degradation of glycosidic bonds of chitin. In this study, we identified and characterized a full-length cDNA of the chitinase gene (BdCht2) in the oriental fruit fly, Bactrocera dorsalis. The cDNA contains an open reading frame (ORF) of 1449 bp that encodes 483 amino acid residues and 126- and 296-bp non-coding regions at the 5'- and 3'-ends, respectively. The BdCht2 genome has four exons and three introns. The predicted molecular mass of the deduced BdCht2 is approximately 54.3 kDa, with an isoelectric point of 5.97. The 977 bp 5' flanking region was identified and the transcription factor binding sites were predicted. Bioinformatic analyses showed that the deduced amino acid sequence of BdCht2 had 34%–66% identity to that of chitinases identified in other insect species. Quantitative real-time PCR (qPCR) analyses indicated that BdCht2 was mainly expressed during the larval-pupal and pupal-adult transitions. The tissue-specific expression showed that the highest expression was in the integument, followed by the fat body and other tissues. Moreover, the expression of BdCht2 was upregulated significantly upon 20-hydroxyecdysone (20E) at different dose injections after 8 h compared to that of the control. Starvation also increased the expression of BdCht2 in the third-instar larvae and was suppressed again by re-feeding the insects. These results suggest that BdCht2 plays an important role in the molting process of B. dorsalis larvae and can be regulated by 20E.
Targeting of Rho Kinase Ameliorates Impairment of Diabetic Endothelial Function in Intrarenal Artery
Authors: Yin Hongping , Ru Hailong , Yu Liping , Kang Yanhua , Lin Guohua , Liu Chuanfei , Sun Lixian , Shi Liyun , Sun Qinghua , Liu Cuiqing
Published: October 2013

Endothelial dysfunction in kidney vasculature is the initial and key element for nephropathy in diabetes mellitus. Accumulating evidence suggests the protective role of Rho kinase inhibitors in endothelial dysfunction via modulating eNOS activity and NO production. However, the role of Rho kinase in diabetes-related endothelial dysfunction in kidney vasculature and the relevant mechanisms remain unknown. We assessed whether pharmacological inhibition of Rho kinase attenuates endothelial dysfunction in intrarenal arteries from type 1 diabetic rats. Fasudil, a Rho kinase inhibitor effectively decreased the phosphorylated level of MYPT1 without affecting the expression of ROCKs in the kidney. Fasudil treatment showed no improvement in diabetes-related abnormality in metabolic indices, but it significantly ameliorated endothelial dysfunction in intrarenal arteries and lessened the mesangial matrix expansion in the kidney cortex. Mechanistically, superoxide production in the intrarenal artery and NOX4 member of NADPH oxidase in the renal cortex that contribute to diabetic nephropathy were also prevented by the Rho kinase inhibitor. In conclusion, the present results indicate that Rho kinase is involved in endothelial dysfunction in type 1 diabetes via enhancement of oxidative stress and provides new evidence for Rho kinase inhibitors as potential therapeutic agents for the treatment of diabetic nephropathy.
Strengths and Weaknesses of Recently Engineered Red Fluorescent Proteins Evaluated in Live Cells Using Fluorescence Correlation Spectroscopy
Authors: Siegel Amanda , Baird Michelle , Davidson Michael , Day Richard
Published: October 2013

The scientific community is still looking for a bright, stable red fluorescent protein (FP) as functional as the current best derivatives of green fluorescent protein (GFP). The red FPs exploit the reduced background of cells imaged in the red region of the visible spectrum, but photophysical short comings have limited their use for some spectroscopic approaches. Introduced nearly a decade ago, mCherry remains the most often used red FP for fluorescence correlation spectroscopy (FCS) and other single molecule techniques, despite the advent of many newer red FPs. All red FPs suffer from complex photophysics involving reversible conversions to a dark state (flickering), a property that results in fairly low red FP quantum yields and potential interference with spectroscopic analyses including FCS. The current report describes assays developed to determine the best working conditions for, and to uncover the shortcoming of, four recently engineered red FPs for use in FCS and other diffusion and spectroscopic studies. All five red FPs assayed had potential shortcomings leading to the conclusion that the current best red FP for FCS is still mCherry. The assays developed here aim to enable the rapid evaluation of new red FPs and their smooth adaptation to live cell spectroscopic microscopy and nanoscopy.
Significant Overexpression of DVL1 in Taiwanese Colorectal Cancer Patients with Liver Metastasis
Authors: Huang Ming-Yii , Yen Li-Chen , Liu Hsueh-Chiao , Liu Po-Ping , Chung Fu-Yen , Wang Tsu-Nai , Wang Jaw-Yuan , Lin Shiu-Ru
Published: October 2013

Undetected micrometastasis plays a key role in the metastasis of cancer in colorectal cancer (CRC) patients. The aim of this study is to identify a biomarker of CRC patients with liver metastasis through the detection of circulating tumor cells (CTCs). Microarray and bioinformatics analysis of 10 CRC cancer tissue specimens compared with normal adjacent tissues revealed that 31 genes were up-regulated (gene expression ratio of cancer tissue to paired normal tissue > 2) in the cancer patients. We used a weighted enzymatic chip array (WEnCA) including 31 prognosis-related genes to investigate CTCs in 214 postoperative stage I–III CRC patients and to analyze the correlation between gene expression and clinico-pathological parameters. We employed the immunohistochemistry (IHC) method with polyclonal mouse antibody against DVL1 to detect DVL1 expression in 60 CRC patients. CRC liver metastasis occurred in 19.16% (41/214) of the patients. Using univariate analysis and multivariate proportional hazards regression analysis, we found that DVL1 mRNA overexpression had a significant, independent predictive value for liver metastasis in CRC patients (OR: 5.764; 95% CI: 2.588–12.837; p < 0.0001 on univariate analysis; OR: 3.768; 95% CI: 1.469–9.665; p = 0.006 on multivariate analysis). IHC staining of the immunoreactivity of DVL1 showed that DVL1 was localized in the cytoplasm of CRC cells. High expression of DVL1 was observed in 55% (33/60) of CRC tumor specimens and was associated significantly with tumor depth, perineural invasion and liver metastasis status (all p < 0.05). Our experimental results demonstrated that DVL1 is significantly overexpressed in CRC patients with liver metastasis, leading us to conclude that DVL1 could be a potential prognostic and predictive marker for CRC patients.
Advances in the Research of Melatonin in Autism Spectrum Disorders: Literature Review and New Perspectives
Authors: Tordjman Sylvie , Najjar Imen , Bellissant Eric , Anderson George , Barburoth Marianne , Cohen David , Jaafari Nemat , Schischmanoff Olivier , Fagard Rémi , Lagdas Enas , Kermarrec Solenn , Ribardiere Sophie , Botbol Michel , Fougerou Claire , Bronsard Guillaume , Vernay-Leconte Julie
Published: October 2013

Abnormalities in melatonin physiology may be involved or closely linked to the pathophysiology and behavioral expression of autistic disorder, given its role in neurodevelopment and reports of sleep-wake rhythm disturbances, decreased nocturnal melatonin production, and beneficial therapeutic effects of melatonin in individuals with autism. In addition, melatonin, as a pineal gland hormone produced from serotonin, is of special interest in autistic disorder given reported alterations in central and peripheral serotonin neurobiology. More specifically, the role of melatonin in the ontogenetic establishment of circadian rhythms and the synchronization of peripheral oscillators opens interesting perspectives to ascertain better the mechanisms underlying the significant relationship found between lower nocturnal melatonin excretion and increased severity of autistic social communication impairments, especially for verbal communication and social imitative play. In this article, first we review the studies on melatonin levels and the treatment studies of melatonin in autistic disorder. Then, we discuss the relationships between melatonin and autistic behavioral impairments with regard to social communication (verbal and non-verbal communication, social interaction), and repetitive behaviors or interests with difficulties adapting to change. In conclusion, we emphasize that randomized clinical trials in autism spectrum disorders are warranted to establish potential therapeutic efficacy of melatonin for social communication impairments and stereotyped behaviors or interests.
The Key Enzyme of the Sialic Acid Metabolism Is Involved in Embryoid Body Formation and Expression of Marker Genes of Germ Layer Formation
Authors: Weidemann Wenke , Hering Jessica , Bennmann Dorit , Thate Annett , Horstkorte Rüdiger
Published: October 2013

The bi-functional enzyme UDP-N-acetyl-2-epimerase/N-acetylmannosamine kinase (GNE) is the key enzyme of the sialic acid biosynthesis. Sialic acids are negatively charged nine carbon amino sugars and are found on most glycoproteins and many glycolipids in terminal positions, where they are involved in a variety of biological important molecular interactions. Inactivation of the GNE by homologous recombination results in early embryonic lethality in mice. Here, we report that GNE-deficient embryonic stem cells express less differentiation markers compared to wild-type embryonic stem cells. As a result, GNE-deficient embryonic stem cells fail to form proper embryoid bodies (EB) within the first day of culture. However, when culturing these cells in the presence of sialic acids for three days, also GNE-deficient embryonic stem cells form normal EBs. In contrast, when culturing these cells in sialic acid reduced medium, GNE-deficient embryonic stem cells proliferate faster and form larger EBs without any change in the expression of markers of the germ layers.
N,N′-Bis-(4-nitrophenylcarbamothioyl)phthalamide
Authors: Aydin Fatma , Dagci Erdogan
Published: October 2013

A novel colorimetric receptor linked to two nitrophenylurea groups was synthesized in good yields, characterized and their chromogenic properties investigated towards various anions (F−, Cl−, Br−, I−, OH−, AcO−, H2PO4− and CN−) by UV-Vis techniques. The receptor, effectively and selectively, recognized and distinguished the biologically important F− from other anions such as Cl−, Br−, I− etc. in DMSO. This selectivity could be easily observed by the naked eye, indicating that receptor is potential colorimetric sensor for fluoride ion.
Carbon Derived from Jatropha Seed Hull as a Potential Green Adsorbent for Cadmium (II) Removal from Wastewater
Authors: Mohammad Masita , Yaakob Zahira , Abdullah Siti
Published: October 2013

Carbon from jatropha seed hull (JC) was prepared to study the adsorption of cadmium ions (Cd2+) from aqueous solutions under various experimental conditions. Batch equilibrium methods have been used to study the influences of the initial metal ion concentration (0.5–50 ppm), dosage (0.2–1 g), contact time (0–300 min), pH (2–7), and temperature (26–60 °C) on adsorption behavior. It has been found that the amount of cadmium adsorbed increases with the initial metal ion concentration, temperature, pH, contact time, and amount of adsorbent. A kinetic study proved that the mechanism of Cd2+ adsorption on JC followed a three steps process, confirmed by an intraparticle diffusion model: rapid adsorption of metal ions, a transition phase, and nearly flat plateau section. The experimental results also showed that the Cd2+ adsorption process followed pseudo-second-order kinetics. The Langmuir and Freundlich adsorption isotherm models were used to describe the experimental data, with the former exhibiting a better correlation coefficient than the latter (R2 = 0.999). The monolayer adsorption capacity of JC has been compared with the capacities of the other reported agriculturally-based adsorbents. It has been clearly demonstrated that this agricultural waste generated by the biofuel industry can be considered a potential low-cost adsorbent for the removal of Cd2+ from industrial effluents.
Electrochemical Enzyme-Linked Immunosorbent Assay (ELISA) for α-Fetoprotein Based on Glucose Detection with Multienzyme-Nanoparticle Amplification
Authors: Liu Qin-Lan , Yan Xiao-Hui , Yin Xiao-Mao , Situ Bo , Zhou Han-Kun , Lin Li , Li Bo , Gan Ning , Zheng Lei
Published: October 2013

Since glucose biosensors are one of the most popular and widely used point-of-care testing devices, a novel electrochemical enzyme-linked immunosorbent assay (ELISA) for protein biomarkers has been developed based on a glucose detection strategy. In this study, α-fetoprotein (AFP) was used as the target protein. An electrochemical ELISA system was constructed using anti-AFP antibodies immobilized on microwell plates as the capture antibody (Ab1) and multi-label bioconjugates as signal tracer. The bioconjugates were synthesized by attaching glucoamylase and the secondary anti-AFP antibodies (Ab2) to gold nanoparticles (AuNPs). After formation of the sandwich complex, the Ab2-glucoamylase-AuNPs conjugates converted starch into glucose in the presence of AFP. The concentration of AFP can be calculated based on the linear relation between AFP and glucose, the concentration of which can be detected by the glucose biosensor. When the AFP concentration ranged from 0.05 to 100 ng/mL, a linear calibration plot (i (µA) = 13.62033 − 2.86252 logCAFP (ng/mL), r = 0.99886) with a detection limit of 0.02 ng/mL was obtained under optimal conditions. The electrochemical ELISA developed in this work shows acceptable stability and reproducibility, and the assay for AFP spiked in human serum also shows good recovery (97.0%–104%). This new method could be applied for detecting any protein biomarker with the corresponding antibodies.
Bioinformatic Analysis of Differential Protein Expression in Calu-3 Cells Exposed to Carbon Nanotubes
Authors: Li Pin , Lai Xianyin , Witzmann Frank , Blazer-Yost Bonnie
Published: October 2013

Carbon nanomaterials are widely produced and used in industry, medicine and scientific research. To examine the impact of exposure to nanoparticles on human health, the human airway epithelial cell line, Calu-3, was used to evaluate changes in the cellular proteome that could account for alterations in cellular function of airway epithelia after 24 hexposure to 10 μg/mL and 100 ng/mLof two common carbon nanoparticles, single- and multi-wall carbon nanotubes (SWCNT, MWCNT). After exposure to the nanoparticles, label-free quantitative mass spectrometry (LFQMS) was used to study the differential protein expression. Ingenuity Pathway Analysis (IPA) was used to conduct a bioinformaticanalysis of proteins identified in LFQMS. Interestingly, after exposure to ahigh concentration (10 mg/mL; 0.4 mg/cm2) of MWCNT or SWCNT, only 8 and 13 proteins, respectively, exhibited changes in abundance. In contrast, the abundance of hundreds of proteins was altered in response to a low concentration (100 ng/mL; 4 ng/cm2) of either CNT. Of the 281 and 282 proteins that were significantly altered in response to MWCNT or SWCNT respectively, 231 proteins were the same. Bioinformatic analyses found that the proteins in common to both nanotubes occurred within the cellular functions of cell death and survival, cell-to-cell signaling and interaction, cellular assembly and organization, cellular growth and proliferation, infectious disease, molecular transport and protein synthesis. The majority of the protein changes represent a decrease in amount suggesting a general stress response to protect cells. The STRING database was used to analyze the various functional protein networks. Interestingly, some proteins like cadherin 1 (CDH1), signal transducer and activator of transcription 1 (STAT1), junction plakoglobin (JUP), and apoptosis-associated speck-like protein containing a CARD (PYCARD), appear in several functional categories and tend to be in the center of the networks. This central positioning suggests they may play important roles in multiple cellular functions and activities that are altered in response to carbon nanotube exposure.
Force Sensitive Handles and Capacitive Touch Sensor for Driving a Flexible Haptic-Based Immersive System
Authors: Covarrubias Mario , Bordegoni Monica , Cugini Umberto
Published: October 2013

In this article, we present an approach that uses both two force sensitive handles (FSH) and a flexible capacitive touch sensor (FCTS) to drive a haptic-based immersive system. The immersive system has been developed as part of a multimodal interface for product design. The haptic interface consists of a strip that can be used by product designers to evaluate the quality of a 3D virtual shape by using touch, vision and hearing and, also, to interactively change the shape of the virtual object. Specifically, the user interacts with the FSH to move the virtual object and to appropriately position the haptic interface for retrieving the six degrees of freedom required for both manipulation and modification modalities. The FCTS allows the system to track the movement and position of the user’s fingers on the strip, which is used for rendering visual and sound feedback. Two evaluation experiments are described, which involve both the evaluation and the modification of a 3D shape. Results show that the use of the haptic strip for the evaluation of aesthetic shapes is effective and supports product designers in the appreciation of the aesthetic qualities of the shape.
Multi-Channel Hyperspectral Fluorescence Detection Excited by Coupled Plasmon-Waveguide Resonance
Authors: Du Chan , Liu Le , Zhang Lin , Guo Jun , Guo Jihua , Ma Hui , He Yonghong
Published: October 2013

We propose in this paper a biosensor scheme based on coupled plasmon-waveguide resonance (CPWR) excited fluorescence spectroscopy. A symmetrical structure that offers higher surface electric field strengths, longer surface propagation lengths and depths is developed to support guided waveguide modes for the efficient excitation of fluorescence. The optimal parameters for the sensor films are theoretically and experimentally investigated, leading to a detection limit of 0.1 nM (for a Cy5 solution). Multiplex analysis possible with the fluorescence detection is further advanced by employing the hyperspectral fluorescence technique to record the full spectra for every pixel on the sample plane. We demonstrate experimentally that highly overlapping fluorescence (Cy5 and Dylight680) can be distinguished and ratios of different emission sources can be determined accurately. This biosensor shows great potential for multiplex detections of fluorescence analytes.
Water Collection and Distribution Systems in the Palermo Plain during the Middle Ages
Authors: Lofrano Giusy , Carotenuto Maurizio , Maffettone Roberta , Todaro Pietro , Sammataro Silvia , Kalavrouziotis Ioannis
Published: October 2013

It has been said that Palermo is short of available water. However, nothing could be more wrong. Well-documented Arab sources and narrative chronicles reported an abundance of groundwater resources in Palermo Plain since the Middle Ages. The scarcity of sources and surface water in the Palermo Plain, compared to the groundwater abundance, led the inhabitants to use groundwater both for irrigation and domestic usage through a complex and sustainable hydraulic system. Vertical and horizontal (qanāts) wells, conveyed water towards gardens and public fountains making the Arabic Bal’harm (Palermo) a flourishing town. When visitors walk through the streets of Palermo’s historical center, among Arab ruins and Baroque architecture, they hardly imagine that there is a wide and varied cultural heritage of underground cavities hidden in the basements where water flows in intricate networks fed from a numerous springs. Only in recent years was a part of this system brought to light. Moreover, the city still has a wide and fascinating water distribution system consisting of irrigation basin (gebbie), ingenious hydraulic machines named senie, and distribution chessboard of irrigation (saje) and drinking water (catusi) canals. The medieval water collection and distribution systems and their various components in the Palermo Plain are reviewed together with the influence of the Arab water management on environment.
Niveau relatif des dépenses des particuliers suivant le département
Authors: Delcros L. , Matter
Published: October 2013

Mise à jour partielle du numéro spécial « Espace économique français ». Étude par département des dépenses en 1954-1955, complétée par l'examen de l'évolution depuis 1951-1953.
L'échelle mobile des salaires en Italie
Authors: Poncet J.
Published: October 2013

Le système d'échelle mobile des salaires en Italie est conventionnel, temporaire, joue à la baisse comme à la hausse, est général mais forfaitaire. Il consiste en l'attribution d'une indemnité spéciale dite « indemnité de contingence » pour toute hausse (ou même baisse) de un point de la moyenne trimestrielle d'un indice du coût de la vie calculé sur un ensemble de villes. La valeur du point de contingence est fixe pendant toute la durée de l'accord. L'opinion italienne estime que le mécanisme de l'échelle mobile représente un instrument de" tranquillité sociale et que ce mécanisme doit être tel qu'il ne comporte pas d'inconvénient pour l'équilibre du développement économique national.
Notes linguistiques et critiques sur le livre III des Coniques d'Apollonius de Pergè (I)
Authors: Federspiel Michel
Published: October 2013

Suite des précédents articles consacrés aux Livres I et II des Coniques et publiés dans cette Revue. Elle peut aussi servir à compléter le Dictionnaire historique de la terminologie géométrique des Grecs de Ch. Mugler. — Recherches étendues sur ἐπιζευγνύνοα et ἄγειν dans les mathématiques grecques.
Post-Ugi gold-catalyzed diastereoselective domino cyclization for the synthesis of diversely substituted spiroindolines
Authors: Kumar Amit , Vachhani Dipak D , Modha Sachin G , Sharma Sunil K , Parmar Virinder S , Van der Eycken Erik V
Published: October 2013

An Ugi four-component reaction of propargylamine with 3-formylindole and various acids and isonitriles produces adducts which are subjected to a cationic gold-catalyzed diastereoselective domino cyclization to furnish diversely substituted spiroindolines. All the reactions run via an exo-dig attack in the hydroarylation step followed by an intramolecular diastereoselective trapping of the imminium ion. The whole sequence is atom economic and the application of a multicomponent reaction assures diversity.
Les systèmes sont-ils conservateurs ?
Authors: Nizard Georges
Published: October 2013

Les systèmes sociaux et les organisations qui en sont les sous-ensembles significatifs sont fondamentalement conservateurs. Leurs stabilités homéostatiques font leur pérennité. La culture au niveau groupal et les refus du changement de l’acteur se conjuguent pour conformer le système à lui-même. Cependant, le système est menacé, à la fois de l’extérieur par la turbulence de l’environnement, et en interne par les déviances de l’acteur et des jeux de pouvoir. Aujourd’hui, des systèmes ouverts adaptatifs seraient une réponse et une remise en cause des stabilités pérennes. Face à l’immobilisme du système, que peut le consultant appelé à changer les valeurs et les pratiques ?
Institution, systémique et anorexie mentale
Authors: Malarewicz Jacques Antoine
Published: October 2013

En se focalisant sur la question de la prise en charges de l’anorexie mentale, l’auteur rapporte son expérience, d’une durée de 10 ans, dans la conduite d’un service d’hospitalisation consacré aux adolescents. Cette expérience a permis de mettre en place un processus où étaient constamment mises en parallèle et en lien certaines des dimensions de la dynamique familiale avec celles du quotidien de l’institution. Il en a résulté plusieurs conséquences, notamment sur les durées du séjour manifestement réduites, le confort de l’équipe de soin renforcé. Surtout, le choix du moment de la sortie des patients a pu être corrélé à d’autres facteurs que la guérison apparente.
Isomorphisme, urgence et instabilité dans un centre Mena
Authors: Le Cardinal Anne-Laure
Published: October 2013

L’isomorphisme permet d’analyser le fonctionnement et les blocages d’une institution, mais aussi de mieux saisir les fonctionnements et blocages des patients dont elle s’occupe. À partir de quelques éléments qui sont propres au profil des mineurs étrangers non accompagnés, je vais tenter de montrer qu’on peut les retrouver au niveau du fonctionnement de l’équipe. Il ne s’agit pas seulement de mettre en évidence un parallèle mais de comprendre les mécanismes qui président à l’installation de celui-ci et des conséquences que l’on peut en tirer au niveau de notre pratique. Je développerai donc l’horizontalité comme mode de fonctionnement de l’équipe, l’instabilité dans la composition de celle-ci et enfin la circulation particulière de l’information. J’essaierai d’en tirer des pistes sur les moyens à se donner pour que la prise de conscience de cet isomorphisme puisse venir nourrir notre travail et que ce qui apparaît à première vue comme des obstacles se transforme en outil au service de notre population.
Réflexion sur la collaboration interdisciplinaire
Authors: Gagnier Jean-Pierre , Roy Linda
Published: October 2013

Les pratiques institutionnelles sont appelées à se transformer. Le travail de collaboration interdisciplinaire, en lien avec le patient et sa famille, exige de coordonner les multiples expertises des divers professionnels dans l’inévitable corps à corps avec des situations médicales et psychosociales complexes. Les pratiques de collaboration interprofessionnelles doivent sans aucun doute être considérées comme des leviers de changements structurels, culturels et cliniques. Dans cet article, nous portons une attention particulière à la réunion interdisciplinaire comme moment ritualisé et structuré de travail collectif avec des patients hospitalisés et leurs proches.
Psychothérapie familiale et schizophrénie. Dynamique des indices systémiques d'adaptation et de psychopathologie
Authors: Medvedev Serguey
Published: October 2013

L’article décrit une recherche prospective comparative, randomisée et menée en parallèle. La comparaison de la dynamique des indices systémiques et psychopathologiques au niveau de la compétence sociale de deux groupes de patients traités différemment met en évidence l’efficacité de la thérapie familiale systémique dans le cadre de la réhabilitation des malades atteints de la schizophrénie paranoïde.
Et si les institutions acceptaient de soigner leurs maux ?
Authors: Vander Borght Christine
Published: October 2013

Les institutions de soins et d’éducation, comme n’importe quel groupe humain organisé, sont sujettes à des maladies et doivent se donner les moyens de se soigner. L’espace de supervision peut en être un, qu’il soit préventif ou curatif. Nous chercherons à comprendre ce qui constitue la spécificité d’un tel espace/temps, et à préciser quelques manières de faire pour poser la mise en place d’un cadre de travail défini comme une « matrice d’empathie ». L’espace de supervision doit pouvoir soutenir un processus d’intelligence collective.
Souffrances dans le milieu professionnel... Lieux professionnels en souffrance
Authors: Trioullier Olivier
Published: October 2013

Cet article aborde les souffrances au travail, spécifiquement chez les professionnels dans le champ des relations d’aide, d’accompagnement ou de soin. Deux questions sous-jacentes nous servent de lignes directionnelles et précisent notre démarche : l’une autour de certaines des conséquences de cette souffrance pour ces professionnels en tant que personnes, lorsqu’elles se trouvent dans l’exercice de leur métier ; et l’autre sur les influences des modèles familiaux de ces mêmes professionnels sur le lien professionnel et aussi sur les institutions où ils travaillent. Nous essayons de relier ces aspects au contexte social dans lequel se situent ces institutions et tentons enfin de dégager quelques-uns des phénomènes qui, dans notre expérience, se retrouvent le plus fréquemment au cœur des problématiques survenant dans les équipes de professionnels.
L'« interinstitutionnel » et les règles implicites
Authors: Darnaud Thierry , Pluymaekers Jacques
Published: October 2013

Dans cet article, nous montrerons l’importance pour la clinique de considérer comme « faisant système » les institutions appelées à intervenir successivement dans une situation ou celles qui se retrouvent à agir ensemble auprès d’une même famille. En effet, s’y développent, à côté des programmes officiels de chaque institution, des règles implicites régulant ce macrosystème que nous appelons l’« interinstitutionnel ». Une lecture systémique de l’émergence de ces règles implicites permet souvent de comprendre comment s’articulent les logiques d’interventions des différents intervenants et les conditions dans lesquelles nous sommes interpellés en tant qu’intervenant.
Quand le parcours de soins rencontre le champ judiciaire : un méta-système thérapeutique ?
Authors: Rassinon Samuel , Wawrzyniak Michel
Published: October 2013

Comment intégrer la dimension de l’intervention pénale dans une perspective thérapeutique ? Nous examinons ici cette question à travers le traitement judiciaire d’un crime – une situation d’inceste – lors d’une session en Cour d’Assises. Notre hypothèse est que, par le déroulé de la session d’assises, s’institue un méta-système créant une synchronisation de l’ensemble des sous-systèmes dont ceux de soin et de protection. C’est à partir de la rencontre clinique avec Sophie en institution pédopsychiatrique, puis du procès en Cour d’assises de son agresseur auquel nous avons assisté dans le cadre de notre formation systémique, que nous déploierons notre argumentation.
« Ambiguïtés et paradoxes en Accueil Familial Thérapeutique : Questions d'identités »
Authors: Jung Johann
Published: October 2013

Parmi les différentes modalités de soin proposées en pédopsychiatrie, l’Accueil Familial Thérapeutique s’inscrit comme un dispositif à la fois original et complexe. À l’interface du soin et du « médico-social », de l’éducatif et de la thérapeutique, ce type de prise en charge peut être amené, même après plusieurs années d’expérience, à « souffrir » d’une identité aux contours mal définis. En témoigne la diversité des représentations que peuvent s’en faire les équipes soignantes, l’assimilant tantôt à un accueil social, tantôt à une alternative aux prises en charges existantes. Cependant, cette problématique de l’identité, qui traverse l’Accueil Familial Thérapeutique, contient aussi en elle-même des ambiguïtés fécondes, voire des paradoxes dont les effets nous invitent à réfléchir aux enjeux thérapeutiques de ce dispositif. Trois axes sont successivement abordés : la question de l’identité professionnelle de l’Assistante Familiale inscrite dans l’entre-deux du soin et du social, à partir de la double référence de la profession à l’hôpital et au conseil général ; les effets de l’accueil à domicile sur l’engagement de l’assistante familiale à un niveau personnel et professionnel, enfin, le rapport entre la demande et l’indication en AFT.
Finding and Evaluating Great Educational Games
Authors: Gopin Elisa
Published: October 2013

Digital games are increasingly being used as educational tools. They are intrinsically motivating for many students and offer a natural learning environment. However, not all games are equally effective in the classroom and there is thus a need for frameworks to guide teachers so that learning goals are aligned with a game’s goals and to determine whether or not the game design supports effective learning. This chapter offers an analysis framework that can be used by classroom teachers to understand the different ways that games can support learning and to critique specific games to determine whether or not they meet the learning requirements. The chapter includes a checklist for teachers, as well as a feedback form for students who playtest games for use in the classroom.
Designing an Online Interactive Learning Program to Improve Chinese Migrant Children’s Internet Skills
Authors: Li Yan , Guo Niki Y. , Ranieri Maria
Published: October 2013

The purpose of this chapter is to design and implement an online interactive learning program to improve migrant children’s Internet skills. With the help of the Italian Association of Media Education, the authors designed an online program (http://yzj.edulife.eu/j/?lang=en) comprised of five interactive learning modules, including an array of practice activities to support students’ development of retrieving, assessing, storing, producing, presenting, and exchanging information. During the 2011 spring semester, 143 fourth and fifth grade students from Minzhu Experimental School were invited to attend the program with the guidance of three ICT educators and two researchers. Pre- and post-tests and interviews examined the effectiveness of the program. Data analysis found that migrant children’s Internet self-efficacy and Internet exploratory behavior were significantly improved by attending the program. Based on observed program limitations, suggestions for improvement are proposed in the last section of the chapter.
The Development and Application of Regional Education Informatization in China
Authors: Zuo Mingzhang , Liu Sisi , Zhao Ziyun
Published: October 2013

Education informatization has become a significant symbol of educational modernization. Over the past 20 years, China has made remarkable achievements in the development of information technology infrastructure, resources, and personnel training. Despite the initial success on the education informatization management, China is still facing many challenges in primary and secondary schools’ education informatization: ineffective digital educational resource sharing mechanism (lack of public information technology service platform), insufficient quality education resources (i.e., campus network infrastructure and teachers’ information technology capabilities), poorly integrated education informationalized system management (i.e., slow deployment and limited functionality), insufficient information capabilities training for the teacher, imbalanced development in regional education informatization (i.e., funding shortage in rural areas), and lack of sustainable development policies. Thus, how to resolve these challenges and to prepare primary and secondary schools for the 21st century classroom has become an urgent issue in reaching China’s ambitious goal of 100% network connection. By examining the current status of education informationalized development in three different economic areas in China, this chapter collects, complies, compares, and evaluates the application and development of regional education informatization including information technology hardware, informational network, information capabilities, and education informatization development funds in primary and secondary schools. Recommendations are made to improve the process of education informatization development and application; to reduce the regional gaps in education informatization; to accelerate the development of network resources, network infrastructure, and informationalized platform; to improve information technology capability training; and to establish better policies for sustainable development of education informatization in China.
Embedding Work Culture in Building Information Modelling (BIM) for Enhancing Collaboration in Global Projects
Authors: Abdul Ghafar Maszura , Ibrahim Rahinah , Shari Zalina , Pour Rahimian Farzad
Published: October 2013

Building Information Modelling is further globalising Architecture, Engineering and Construction (AEC) professional partnerships. However, little is known on the effect of cultural and human factors on BIM enabled visualisation applications. This desktop study examined the extant literature on factors relating to application of BIM enabled visualisation technologies as a process that can improve, leverage and conduct visual communication for coordination during implementation of global projects. It identifies BIM enabled visualisation having the capability in facilitating knowledge flows in complex discontinuous working environment of a property development’s life cycle, and supports designers’ understanding in its early working phases. This paper presents the development of a theoretical proposition for embedding local work culture etiquette in BIM enabled visualisation application for augmenting dynamic knowledge transfer among discontinuous members in a building project. The result is expected to benefit rapidly developing countries, e.g. Malaysia, in enabling successful partnerships with counterparts from developed countries.
A Unified Information Framework for Building A Common Vision in Sustainable City Development
Authors: Yao Jialiang , Fernando Terrence , Everall Ian
Published: October 2013

Creating sustainable cities requires a stronger collaboration between a range of public and private sector organisations to ensure cities are safer, healthier, intelligent and prosperous places for citizens to experience an enhanced quality of life. Within this context, urban planning and regeneration projects play a major role where stakeholders need to come together to assess the current challenges or the opportunities within a city and implement projects that transform the physical, social and environmental dimensions to create prosperous and sustainable futures. Within these projects, stakeholders need to assess “social data intelligence” collected by individual agencies and also understand how proposed complex agendas such as transport, health, education and employment could lead to a better environment that can bring social, economical and environmental prosperity. This research proposes a novel Urban Information Framework that allows the stakeholders to integrate their datasets (both spatial and non-spatial) together to create a unified 3D virtual prototype of a city that can be used to represent both the current state of a city as well as intended futures. The proposed Urban Information Framework allows the stakeholders to combine different datasets together, whether they be social or physical transformation agendas, to understand the dependencies or to build up narratives that could be communicated visually to others. The overall framework has been developed and validated by working closely with two major regeneration projects in UK.
Content Approval Systems with Expansions of a New Pair-Connected-Structured Aggregate Signature Scheme
Authors: Inamura Masaki , Iwamura Keiichi
Published: October 2013

In this study, the authors propose new aggregate signature schemes with pairing-based cryptography that can describe the pair-connected structure of signers and examples of new content approval systems with these schemes. Existing structured signature schemes are based on multisignature schemes, which are adapted for verification of a structure if all signers sign the same document. However, if each signer wants to sign a document different from those of other signers, another scheme that is based on an aggregate signature scheme is required. To resolve the above problem, a denoted connective signature is generated in this scheme and can be adapted for verification of variant structures with its expansion. In addition, the authors show examples of effective content approval systems, which can be realize with verifying not only who signs but also which division each of signers belongs to.
3D Printing: Basic Concepts Mathematics and Technologies
Authors: Rompas Alexander , Tsirmpas Charalampos , Papatheodorou Ianos , Koutsouri Georgia , Koutsouris Dimitris
Published: October 2013

3D printing is about being able to print any object layer by layer. But if one questions this proposition, can one find any three-dimensional objects that can't be printed layer by layer? To banish any disbeliefs the authors walked together through the mathematics that prove 3d printing is feasible for any real life object. 3d printers create three-dimensional objects by building them up layer by layer. The current generation of 3d printers typically requires input from a CAD program in the form of an STL file, which defines a shape by a list of triangle vertices. The vast majority of 3d printers use two techniques, FDM (Fused Deposition Modelling) and PBP (Powder Binder Printing). One advanced form of 3d printing that has been an area of increasing scientific interest the recent years is bioprinting. Cell printers utilizing techniques similar to FDM were developed for bioprinting. These printers give us the ability to place cells in positions that mimic their respective positions in organs. Finally, through a series of case studies the authors show that 3d printers have made a massive breakthrough in medicine lately.
Theoretical Framework and Denotatum-Based Models of Knowledge Creation for Monitoring and Evaluating R&D Program Implementation
Authors: Zatsman Igor , Buntman Pavel
Published: October 2013

The paper presents two semiotic models for a description of development stages of indicators, including generation processes of expert knowledge about developed indicators. For the description of stages of these processes, a new notion of “Frege’s space“ is introduced. The authors described two applied semiotic models of knowledge acquisition. Those processes were studied in the context of forming an expert knowledge base named proactive dictionary, which represents a component of an evaluation system. This dictionary enables experts to fix stages of indicators development, to present the results of developing different variants of indicators in graphic form, to compare and evaluate these variants.
Application Workload Modelling via Run-Time Performance Statistics
Authors: Khan Subayal , Saastamoinen Jukka , Huusko Jyrki , Soininen Juha-Pekka , Nurmi Jari
Published: October 2013

Modern mobile nomadic devices for example internet tablets and high end mobile phones support diverse distributed and stand-alone applications that were supported by single devices a decade back. Furthermore the complex heterogeneous platforms supporting these applications contain multi-core processors, hardware accelerators and IP cores and all these components can possibly be integrated into a single integrated circuit (chip). The high complexity of both the platform and the applications makes the design space very complex due to the availability of several alternatives. Therefore the system designer must be able to quickly evaluate the performance of different application architectures and implementations on potential platforms. The most popular technique employed nowadays is termed as system-level-performance evaluation which uses abstract workload and platform capacity models. The platform capacity models and application workload models reside at a higher abstraction-level. The platform and application workload models can be instantiated with reduced modeling effort and also operate at a higher simulation speed. This article presents a novel run-time statistics based application workload model extraction and platform configuration technique. This technique is called platform COnfiguration and woRkload generatIoN via code instrumeNtation and performAnce counters (CORINNA) which offers several advantages over compiler based technique called ABSINTH, and also provides automatic configuration of the platform processor models for example cache-hits and misses obtained during the application execution.
Novel Approaches for Integrating MART1 Clustering Based Pre-Fetching Technique with Web Caching
Authors: Sathiyamoorthi  , Bhaskaran Murali
Published: October 2013

Web caching and Web pre-fetching are two important techniques for improving the performance of Web based information retrieval system. These two techniques would complement each other, since Web caching provides temporal locality whereas Web pre-fetching provides spatial locality of Web objects. However, if the web caching and pre-fetching are integrated inefficiently, this might cause increasing the network traffic as well as the Web server load. Conventional policies are most suitable only for memory caching since it involves fixed page size. But when one deals with web caching which involves pages of different size. Hence one need an efficient algorithm that works better in web cache environment. Moreover conventional replacement policies are not suitable in clustering based pre-fetching environment since multiple objects were pre-fetched. Hence, it cannot be handled by conventional algorithms. Therefore, care must be taken while integrating web caching with web pre-fetching technique in order to overcome these limitations. In this paper, novel algorithms have been proposed for integrating web caching with clustering based pre-fetching technique. Here Modified ART1 has been used for clustering based pre-fetching technique. The proposed algorithm outperforms the traditional algorithms in terms of hit rate and number of objects to be pre-fetched. Hence saves bandwidth.
A Hybrid Approach for Web Change Detection
Authors: Alqaaidi Sakher Khalil
Published: October 2013

Search engines save copies of crawled web pages to provide instant search results, saved pages may become old and un-updated as original pages change providing new information and new links, and most of websites don’t submit these new changes to search engines so search engines don’t depend mainly on websites techniques of submitting changes. Keeping pages fresh and updated in search engine is important for giving real page ranks and for providing real time information. Techniques were invented to improve the page update process by search engine. In this paper the author combines two of good known techniques and implements the new one via experiments that improve better results in different experiment cases.