bluuebunny/crossref_metadata_2025 huggingface dataset:
GFAP as an immunohistochemical marker in traumatic brain injuries
Authors: Khachatryan Parandzem , Bisharyan Mher , Meliksetyan Lilit , Hovhannisyan Alina , Mkhitaryan Armen
Published: December 2023

Introduction: Head injury recently replaced by the new term: traumatic brain injury (TBI) is a common cause of death worldwide and many researchers report it as a global health problem. The main cause of TBI is associated with various forms of violent, domestic, or accidental death. In these cases, an autopsy is mandatory to understand the immediate cause of death and its relationship to the TBI. Our study aimed to understand the general histopathological changes and expression of various immunohistochemical markers in TBI at medico-legal autopsies. Material and methods: Autopsies were performed on 20 cadavers whose cause of death was a traumatic brain injury and 20 cadavers with sudden deaths. The postmortem examination was performed by a forensic expert under the Virchow method. After labeling of brain tissues and fixation in formalin solution, they were transported to the histological department. The tissues were stained with hematoxylin and eosin (H&E) for histological assessment. Additional slices were taken for immunohistochemical examination. In our research, we used primary antibodies for GFAP, Ki67, and NeuN immunohistochemical markers. Results: The main histological changes in TBI were subarachnoid hemorrhages, perineuronal and perivascular edema, small foci of erythrocyte extravasation, and capillary stasis. From the immunohistochemical markers, GFAP showed some specific and interesting changes. Conclusions: Our data show that GFAP can serve as an immunohistochemical marker for TBI and its immunohistochemical staining changes can be a sequence of time-dependent events in TBI.
POLARIZED ACTIVATION OF HUMAN PERIPHERAL BLOOD PHAGOCYTES BY BACTERIOPHAGE–DERIVED DOUBLESTRANDED RNA (LARIFAN) in vitro
Authors:   1Taras Shevchenko National University of Kyiv, Ukraine, Dovhyi R.
Published: December 2023

Aim. This study aimed to examine the effect of Larifan on metabolic characteristics of human blood monocytes and granulocytes in vitro. Methods. Four healthy adult men aged 21–26 years were recruited to participate in the study as blood donors. The metabolic profile of human blood monocytes and granulocytes was evaluated by phagocytic activity, reactive oxygen species production, nitric oxide generation, and arginase activity. Phagocytosis of FITC-labeled inactivated Staphylococcus aureus and reactive oxygen species generation were estimated by flow cytometry. Arginase activity was assessed in cell lysates, and nitric oxide generation in supernatants was examined using the Griess reaction. Results. Phagocytic index and reactive oxygen species generation were found to be lower in both human blood monocytes and granulocytes treated with Larifan. The drug caused a dose-dependent increase in nitric oxide production, as well as a decrease in the arginase activity of blood monocytes. Conclusions. Our results indicate the ability of Larifan to reinforce the antiviral properties of resting phagocytes along with containment of oxidative stress development.
Analysis of Innovative Methods of Computer Data Loss Prevention
Authors: Kapiton А.M. , Dziuban О.S. , Franchuk Т.M. , Yatsenko I.L.
Published: December 2023

The influence of the development of information technologies on the improvement and devel-opment of innovative methods of preventing the loss of computer data is considered. It has been proven that the development of computer network technologies is gradually accelerating, as today vulnerability is considered a potential threat to information security. The main prob-lems of computer information leakage and computer software encryption technology to prevent computer information leakage are analyzed. Classification of the information leak has been car-ried out. The consequences of information leakage, which have an impact on the economic ben-efits of enterprises or individuals, have been studied. Data leakage prevention methods have been proposed and are currently relevant, including technical tools and product solutions such as traditional DSM (Data Encryption Management) and DSA (Data Security Isolation), as well as DLP (Data Leak Prevention) based. The protection technology to contain the leakage of computer information was analyzed. It is justified that due to the fact that electrostatic shielding is used to prevent electrostatic communication interference, it is advisable to use grounding conductors. It is determined that electromagnetic shielding uses the principle of reflection and absorption of electromagnetic waves on the surface of the conductor and inside the conductor to protect against high voltage interference.
Analysis of the state of the art and the trends in the development of the target characteristics of orbital constellations of small agriculture-oriented Earth re-mote sensing spacecraft
Authors:   Institute of Technical Mechanics of the National Academy of Sciences of Ukraine and the State Space Agency of Ukraine, Khramov D.O. , Volosheniuk O.L. ,   Institute of Technical Mechanics of the National Academy of Sciences of Ukraine and the State Space Agency of Ukraine
Published: December 2023

The goal of this paper is to assess the existing capabilities of orbital constellations of agriculture-oriented Earth remote sensing spacecraft and the prospects for their development in the nearest future. The paper analyzes the state of the art and the trends in the development of modern orbital constellations of private companies’ small Earth remote sensing satellites used in solving agricultural problems. Important sources of information in the space industry, such as NewSpace Index, Gunter's Space Page, and WMO OSCAR, were analyzed. 52 constellations of spacecraft for optical multispectral and hyperspectral, thermal, and microwave (radar) imaging are considered. It is shown that they provide a survey frequency of several times a day. The minimum spatial resolution of optoelectronic surveillance sensors is 1 m (in the panchromatic channel). This allows one to solve problems at an intrafield level, quasi-continuously monitor the plant condition, and use spectral patterns and texture features in solving applied agricultural problems. All the constellations of radar satellites use the X-band, except for the radars of the Spacety constellation (China), which use the C-band. It is shown that the number of constellations of small remote sensing spacecraft in the period 2021–2025 is to be increased by more than three times compared to the period 2016–2020. The number of countries developing constellations of Earth remote sensing satellites has increased significantly. The leading countries and companies in the number and size of constellations are the United States and China and Planet (USA) and Chang Guang Satellite Technology Corporation (China), respectively. Private developers are particularly interested in thermal infrared imaging and hyperspectral optical imaging data. A new line in the private space industry, which is expected to facilitate the solution of agricultural problems, is the deployment of constellations of small meteorological satellites.
Algorithms for stabilizing the rotor speed of a Darrieus wind power plant con-trolled by blade length variation
Authors:   Institute of Transport Systems and Technologies of the National Academy of Sciences of Ukraine, Tarasov S.V. , Molotkov O.N. ,   Institute of Transport Systems and Technologies of the National Academy of Sciences of Ukraine
Published: December 2023

The world’s power engineering features ever increasing attention to the development of renewable power sources. Difficulties in provision with traditional energy sources (gas, coal, and oil products) and the global trends of transition to green sources call for replacing the traditional sources with new ones. Among the alternative energy sources, wind power plants (WPPs) installed in suitable territories have received widespread use. Modern WPPs are of two types: vertical- and horizontal-axis ones. Vertical-axis WPPs, as distinct from horizontal-axis ones, have a number of specific advantages, such as, for example, insensitivity to wind direction changes, which significantly simplify the WPP design and increase the WPP reliability. Both WPP types are dynamically complex systems, which operate in different regimes depending on their dynamic and technological features. The task of matching these features is assigned to control systems, which control the rotor operation using additional devices, for example, generators of different types. For horizontal-axis WPPs, approaches to the solution of a number of system control problems have been developed on the basis of the principle of swept area variation. The development of a similar approach for vertical-axis WPPs seems to be an important and promising task. The goal of this paper is to develop efficient algorithms of WPP rotor speed stabilization using the principle of swept area variation, namely, telescopic blades. The problem is solved using methods of the classical automatic control theory and mathematical simulation. The novelty lies in extending the concept of control by swept area variation to Darrieus vertical-axis WPPs, synthesizing efficient algorithms for stabilizing the rotor speed of Darrieus vertical-axis WPPs controlled by blade length variation, and determining conditions for their stability. The algorithms may be used in substantiating design solutions for Darrieus rotor vertical-axis WPPs.
Numerical simulation of a two-phase flow in a jet mill ejector with an additional energy supply
Authors:   Institute of Technical Mechanics of the National Academy of Sciences of Ukraine and the State Space Agency of Ukraine, Ihnatiev O.D. , Shevelova H.M. ,   Institute of Technical Mechanics of the National Academy of Sciences of Ukraine and the State Space Agency of Ukraine
Published: December 2023

New approaches to the preparation and processing of raw materials in the process of jet grinding are gaining more and more importance. This is due to the need to increase the efficiency of grinding and reduce the energy consumption of the equipment, increase its reliability and service life, and expand the possibility of using the jet mill in various industries. All this determines the importance of developing and implementing new approaches to two-phase flow organization in the channels of a jet mill. The goal of this work is to investigate a method for improving two-phase flow organization in the gas jet mill tracts. Numerical studies of a two-phase flow in the ejector of a jet mill showed the advisability of using an additional energy supply through the walls of the accelerating tube of the ejector to increase the efficiency of its operation. Controlling the gas flows in the mill ejector by using the energy of additional gas flows allows one to speed up the main flow at the exit of the ejector accelerating tube and form a protective layer around the tube walls to prevent their wear. The installation of a conical nozzle at the end of the accelerating tube prevents flow separation and vortex formation and provides a uniform velocity distribution at the ejector exit. The paper presents new solutions and recommendations on improving the efficiency of two-phase flow organization in the ducts of a gas jet mill. The scientific significance of the results lies in the development of a gas-dynamic method for controlling the gas flows in the jet mill tracts, which provides a uniform acceleration of the bulk material particles and reduces mill wear. The practical significance lies in the development of recommendations on increasing the efficiency of two-phase flow organization in the gas jet mill tracts. The results may be used in mining, metal manufacture, construction, the chemical and the food industry, and agriculture, and they will be employed in further development of scientific fundamentals of gas jet mill improvement.
Molecular Profile of Metallo-β-Lactamase Producing Bacterial Isolates from Clinical Samples; South-South Nigeria Perspective
Authors: Akereuke U.E. , Onwuezobe I.A. , Ekuma A.E. , Edem E.N. , Uko N.S. , Okon R.S. , Bawonda E.O. , Ekpenyong E.N.
Published: December 2023

One of the major clinical problems regarding β-lactam antibiotics resistance is attributed to metallo-beta-lactamases (MβL), which are a group of enzymes that is a subset of beta- lactamases belonging to group B of the Ambler classification, which causes hydrolysis of carbapenems. The study was conducted to check the prevalence of MβL and its genes (IMP, VIM, and NDM) among Gram-negative isolates. Methods. 312 clinical samples (urine and wound) were cultured, and antimicrobial susceptibility testing was performed using the conventional disk diffusion method. MβL-phenotypic detection was uncovered by standard bacteriological techniques, MβL genes were amplified using pre-determined conditions set on an AB19700 Applied Biosystem thermal cycler. Results. 157 (56.1%) Gram-negative and 123 (43.9%) Gram-positive were isolated. Escherichia coli 32 (11.4%) and Pseudomonas aeruginosa 32 (11.4%) were the most predominant. Providencia stuartii 3 (1.1%), Klebsiella ornitholytica 2 (0.7%), and Stenotrophomonas maltophilia 1 (0.4%) were some of the less predominant isolates. Imipenem and Ertapenem were the most sensitive, while Gentamicin, Amoxicillin-Clavulanate, and Ceftriaxone were the most resistant. Twelve species (7.6%) were identified as MβL producers. The VIM gene (12: 100%) was the predominant gene, followed by the NDM gene (6: 50%) and the IMP gene (2: 16.7%). Conclusions. The detection of blaVIM, blaNDM, and blaIMP genes in South-south Uyo is really worrisome, and proper infectious control measures should be taken in order to prevent outbreaks of MβL-producing Gram-negative bacteria isolated in Uyo, South South Nigeria.
Ethnographic Observations of the Wartime Everyday Life of the Population of Southern Ukraine: Post-Expedition Reflections
Authors: Bosa Liubov
Published: December 2023

Based on field materials, an attempt has been made to analyze the state of self-awareness among modern residents of the former centre of freedoms of the Zaporizhzhian Army, which included parts of the present-day Dnipropetrovsk and Kherson regions. The transformations taking place in this socio-cultural space and their influence on self-identification processes are traced from an anthropological perspective. Examples of russian imperial attitude towards the cultural landscape of the southern Naddniprianshchyna in different historical periods are provided. Parallels are drawn with the testimonies of the renowned traveller and ethnographer, Alexander Afanasyev-Chuzhbinsky, who, in the mid‑19th century, exploring the region and noted negative trends regarding the economic practices of the new owners of Zaporizhzhia lands. It is argued that a similar destructive impact on nature and culture was the practice of constructing large dams on the Dnipro River during the Soviet period, which generated a distinct conflict between russian imperial and Ukrainian worldviews. Through the prism of the author’s collected testimonies during expeditions to the places of the Cossack Great Meadow visited by A. Afanasyev-Chuzhbinsky, contemporary events during the russian-Ukrainian war are comprehended. The focus is on the issue of the new genocide and ecocide brought by the occupiers to the south of Ukraine as a result of the explosion of the Kakhovka Hydroelectric Power Station. The study reveals family strategies for preserving cultural memory concerning the former landscape and the role of the Zaporizhzhian Cossacks in modern processes of self-identification, through which not only the indigenous inhabitants but also participants of new waves of migration mentally assimilated the Zaporizhzhia heritage. Consequently, the military component of the cultural landscape of the Southern Naddniprianshchyna under the new conditions of the russian-Ukrainian war is capable of indirectly influencing the Ukrainian society. All of this calls for active protective measures regarding the cultural heritage and further comprehensive organization of scientific research in various fields of natural and socio-humanitarian sciences in order to preserve the values of the region and the development of Ukraine as a whole.
ІННОВАЦІЙНИЙ РОЗВИТОК СІЛЬСЬКОГО ГОСПОДАРСТВА УКРАЇНИ В УМОВАХ КОМПЛЕКСНИХ ЗАГРОЗ
Authors: Гончаренко О. , Аніщенко В. , Сіренко К.
Published: December 2023

Вступ. Внаслідок повномасштабної війни Росії проти України, продовольча безпека опинилася під загрозою на світовому рівні. Через знищення або часткове пошкодження сільськогосподарських угідь та втрату врожаю було зафіксовано збитки у розмірі 2,1 млрд доларів. Землі сільськогосподарського призначення пошкодженої мінним забрудненням через нерозривні боєприпаси, що створюють смертельну загрозу для аграгіїв та загалом зафіксовано пряме фізичне бомбардування на сільськогосподарських угіддях.Проблематика. Виробничо-продуктивна стійкість сільськогосподарського виробництва — одне з найголовніших питань сьогодення. Необхідною та важливою виступає система знань та інновацій в сільськогосподарській галузі, де охоплено організації та кооперативи фермерів, лісівників, дорадників, дослідників, представників бізнесу, громадськіорганізації.Мета. Проведення кореляційно-регресійного аналізу інноваційного розвитку сільського господарства України в умовах комплексних загроз.Матеріали й методи. Використано методи багатовимірного статистичного аналізу, методи таксономії для оцінки рівня окремих загроз, метод центра ваги — для вибору показників-репрезентантів загроз інноваційного розвитку.Результати. Проведено аналіз комплексних загроз інноваційного розвитку сільського господарства. Для вихідної сукупності показників, що характеризують окрему загрозу, розраховано матрицю відстаней. Загроза зниження витрат на науково-дослідні роботи у прогнозному періоді здійснює найвищий вплив на рівень інноваційного розвитку сільського господарства. Про це свідчать низькі значення коефіцієнтів парної кореляції та сукупного рівня інноваційного розвитку.Висновки. Кореляційно-регресійний аналіз інноваційного розвитку сільського господарства дає можливість визначити найвищу загрозу, що здійснює вплив на рівень інноваційного розвитку сільського господарства.
MYSTICAL DISCOURSE IN JAVA IN THE 18TH CENTURY NARRATED BY THE BOOK OF CABOLEK
Authors: Nasuhi Hamid
Published: December 2023

This article discusses the discourse of Sufism in the 18th century in Java as narrated by Serat Cabolek by Kiai Yasadipura I (1729-1803). This manuscript tells about the trial of Kiai Ahmad Mutamakin in front of the authorities of the Mataram Kingdom in Kartasura. This cleric from the village of Cabolek, Tuban, in the northern coast of Java was controversial and accused of spreading Ilmu Hak, namely wujudiyah Sufism, to commoners, even though his knowledge capacity was considered inadequate by the religious scholars (ulama) who opposed him. In that trial Kiai Mutamakin was found guilty, but later was granted pardon by King Pakubuwana II (1726-1749). The author of Serat Cabolek not only recorded the chronological details of Kiai Mutamakin's trial, more than that he also emphasized his stance on how the Javanese should direct their religious orientation. Yasadipura I, as a court poet with educational background of pesantren (Islamic boarding school), figured Ketib Anom as an ideal Javanese Muslim. This religious head officer from Kudus is a figure that perfectly described not just having in-depth knowledge of traditional Javanese mysticism, namely the mystical story of Dewaruci, but also mastering and carrying out the provisions of the Shari'a in Islam.
AHL AL-KITĀB THROUGH THE INTERPRETATION OF THE TARTĪB NUZŪLĪ IZZAT DARWAZAH
Authors: Hasan Hamka
Published: December 2023

This article aims to describe the exclusiveness of the interpretation of the tartīb nuzūli model (an interpretation written based on the sūrah order) by Izzat Darwazah in his interpretation, Tafsīr al-Ḥadis. This article found that some ahl al-kitāb is disbelievers (kāfīr), while others are muʾmin. The term ahl al-kitāb is not only used by Jews and Christians but as Majūsī, Ṣābiʾīn, and others also receive books from Allah they also can be categorized as ahl al-kitāb. This article used a thematic interpretation method by collecting verses talking about ahl al-kitāb, and the discussion was carried out using a content analysis approach. We compared Tafsir al-Ḥadith written by Izzat Darwazah and other interpretation works. We concluded that not all ahl al-kitāb have similar attitudes to Prophet Muhammad and Muslims. Based on the Quran revelation order, as the basis of Sūrah’s order in writing this interpretation, Izzat Darwazah explained that the Quran describes the ahl al-kitāb in Mecca as softer than those in Madinah. Ahl al-kitāb in Mecca admitted the existence of Muhammad as the Prophet and Apostle and accepted the truth of his treatise, The Quran. Even they left their old faith and moved to Islam. Then, marriage and food exchange between Muslims and non-Muslims were allowed by the Quran as a big step in the road map of tolerance between Islam and other religions.
Pemikiran Progresif Mahasiswa terhadap Hadis-hadis Misoginis (Studi Kasus terhadap Mahasiswa UIN Syarif Hidayatullah Jakarta)
Authors: Fudhaili Ahmad
Published: December 2023

This study focuses on the discussion of students' progressive thinking towards traditions that are claimed to be misogynistic. The purpose of this study was to determine the extent to which students understand and accept the hadiths that are claimed to be misogynistic. The object or sample of this research is the student of Hadith Science Study Program, Faculty of Ushuluddin UIN Syarif Hidayatullah Jakarta. This research is a type of quantitative research using experimental research. In this study, in addition to data obtained through field research, data were also obtained through library research. The time of the research was carried out from January to September 2020 starting from preparation, observation, research, and collecting the data needed in this study. Based on the results of this study, it was found that the level of literacy or understanding and acceptance of students of the UIN Jakarta Hadith Science Study Program towards misogyny traditions was still relatively poor. This is based on the answers given by respondents who still choose gender-biased answers.
Kontekstualisasi Multikulturalisme dalam Moderasi Beragama untuk Mengonter Narasi Ekstremisme
Authors: Khoiri Ahmad
Published: December 2023

This paper discusses multiculturalism as a crucial concept to counter extremism. The perspective used is the Islamic perspective, with the thesis that diversity is a necessity of God, so that Islam, through the Qur’an, guides human beings regarding ways of living with multicultural principles. At the same time, while some circles want a monocultural order, which is manifested by the proliferation of extremism in the name of Islam, it is as if in the Qur’an there are two contradictory teachings about plurality and how to respond to it. Based on the studies that have been carried out, this paper finds that multiculturalism is a moral-ideal of the Qur'an, while extremism is an ideological doctrine based on the interpretation of the Qur'an itself. Thus, deep multiculturalism can become a counter-narrative of extremism.
Persepsi Ibn Sīnā dan John Locke sebagai Pengetahuan Empiris
Authors: Yazid Rizky
Published: December 2023

This paper focuses on the problem of the perception of Ibn Sīnā and John Locke as an activity of knowing which is an epistemological study in philosophy. Perception therefore, is a process and a certain way to gain knowledge. The problem with this research is that as a philosopher who affirms the important role of perception, he does not necessarily become an empiricist. Or the same concern does not have direct implications for the interest of empiricism. This study uses a comparative method as its approach which aims to obtain similarities and differences regarding the concepts of the two philosophers. The findings of this study are that Ibn Sīnā has instruments for empirical research but is not an adherent of empiricism. While John Locke has the same instrument, which empirical based but as an empiricist
Kerja Dakwah dan Kerja Ilmiah-Positivistik dalam Konteks Pendidikan Tinggi Keagamaan Islam: Titik-Jumpa dan Titik-Pisah
Authors: Bahri Media Zainul
Published: December 2023

This article elucidates two main points. First, the difference between da’wah (Islamic preaching) activities and scientific-positivistic works. Da’wah, for example, is a theological work. To preach is to Invite/to call people to strengthen their beliefs and faith, do good, avoid bad deeds, and in many cases, preaching is to make judgments: right and wrong, misguidance or faith. Conversely, positivistic-scientific work is a scientific activity with methodological tools: there is empirical data (primary and secondary), there are approaches and theories, there are logical and rational explanations, and instead to strengthen belief and faith, scientific work is to find “scientific truth”. There are ontological, epistemological and objective differences between da’wah activities and scientific-positivistic ways. Second, to this day there is still a big problem related to Indonesian State Islamic University or Indonesian State Islamic Institute (UIN/IAIN): is this institution is a da’wah institution because there is an “Islam” within, or a scientific educational institution one because it is also a university that demands a scientific-positivistic ways. This article uses historical, theological and philosophical approaches.
Aktualisasi Zikir Tasawuf Sebagai Metode Pendidikan Spiritual, Moral dan Sosial Bagi Masyarakat Postmodern
Authors: Muvid Muhamad Basyrul
Published: December 2023

This study aims to analyze and find a concept of remembrance of Sufism as a method of spiritual, moral, and social education for postmodern society. The research method used is a literature review which examines various literatures, articles, books, and documentation that support the topic of study. The results of the study show that remembrance of Sufism as an alternative to purify the soul and educate the heart to be cleaner so that it will have an impact on personality and social. The process to get there must go through the stages of takhallī, taḥallī, and tajallī. Then, remembrance of Sufism to be a method of education for spiritual, moral and social aspects must be carried out in the right way, which must be solemn, persistent, repeated, understand the meaning and be presented in the heart. Internalization of Sufism remembrance is important to harmonize spiritual, moral and mu'amalah aspects so that the practice of Sufism does not only strengthen one aspect, but several aspects that make him a moderate, balanced and in accordance with the dictates of Islam itself.
Dialektika Arsitektur dan Teknologi Islam Nusantara: Pengaruh Budaya Lokal dan Nilai-nilai Islam
Authors: Ahmad Habibi Zaman Riawan
Published: December 2023

This article describes cultural acculturation in Islamic architecture and technology in Nusantara. Cultural acculturation in the architectural aspect is limited to two mosques of the early Islamic era in Nusantara, namely the Great Mosque of Demak and the Gedhe Mosque of Yogyakarta Palace. The cultural acculturation of mosque construction is reflected in the main building, the portico, and the supporting elements of the building, as well as the meaning of symbols and ornamens. The meaning of symbols and ornamens explains the strong acculturation of local culture with Islamic values. Specifically on the technological aspect, this article examines the naval and cannon technology of the Islamic era of Demak and later sultanates. The article concludes that the entry of Islam into Nusantara created a struggle between Islam and the local culture, which was influenced by Hinduism, Buddhism, and cults, as well as the original values of the archipelago, which are reflected in the construction of buildings and war equipment.
Reconstrucción biológica de grandes defectos óseos con autoinjerto de peroné vascularizado en huesos largos
Authors: Jover Carbonell Pablo , Zarzuela Sánchez Víctor Manuel , Marín Bertolín Severiano , Marquina Moraleda Vicente , Martínez Bovaira Guillermo , Castillo Ruipérez Laura , Hernández Ferrando Lorenzo
Published: December 2023

Introducción: El autoinjerto vascular de peroné se presenta como una muy buena opción en la reconstrucción de grandes defectos óseos en huesos largos gracias a sus características estructurales y propiedades biológicas.

Materiales y Métodos: Se realizó un estudio observacional descriptivo y retrospectivo que incluyó a todos los pacientes operados con un injerto vascular de peroné aislado o asociado a injerto estructural (técnica de Capanna) desde el 1 de enero de 2014 hasta el 1 de enero de 2021en nuestro hospital.

Resultados: Se realizaron 26 cirugías mediante un injerto vascular de peroné; en 8 de ellas, se utilizó el colgajo vascularizado de peroné para la reconstrucción del defecto óseo en hueso largo. El tamaño medio del defecto era de 7,7 cm. El origen del defecto era postraumático en 5 casos y tumoral en el resto. Se consiguió la consolidación completa en todos los pacientes. Los resultados clínicos y funcionales en las escalas de valoración fueron mejores en pacientes operados en el miembro inferior.

Conclusiones: El uso de un colgajo vascularizado de peroné asociado o no a aloinjerto estructural es una estrategia útil en la reconstrucción de grandes defectos óseos (≥5 cm), independientemente de la causa de la lesión; la supervivencia del injerto y la función son buenas, con una tasa de complicaciones aceptable.
Clasificación de Leonetti y Tigani para fracturas del pilón tibial: validación con residentes de Traumatología y Ortopedia, y fellows en tobillo y pie
Authors: Seletti Maximiliano , González Emanuel , Pendino Ana , Parma Julián , Derico Jeremías
Published: December 2023

Objetivo: Validar la clasificación de Leonetti y Tigani con evaluadores de diferentes niveles de experiencia.

Materiales y Métodos: Se evaluó a 54 pacientes (54 fracturas del pilón tibial) en forma retrospectiva. Se tomaron radiografías de tibia distal, de frente y perfil, y una tomografía computarizada con cortes axiales, sagitales, coronales y reconstrucción 3D. Se incluyeron todos los subtipos de la clasificación de Leonetti y Tigani. Los evaluadores tenían diferentes niveles de entrenamientos: dos eran fellows en pie y tobillo, y dos, residentes del último año de formación. Para determinar la concordancia interobservador, cada caso fue clasificado en tipo I, II, III o IV, según Leonetti y Tigani. Para evaluar la concordancia intraobservador el mismo evaluador analizó los casos a las 6 semanas. Se utilizó el coeficiente kappa para determinar el grado de concordancia entre evaluadores y ese valor fue expresado con un intervalo de confianza del 95%.

Resultados: La concordancia intraobservador fue moderada y muy buena para cada fellow, y buena y muy buena para los residentes, entre la primera y segunda evaluación. La concordancia interobservador arrojó un coeficiente kappa global de 0,7156 (IC95% 0,60-0,83), un valor bueno cuando se consideraron todas las fracturas por todos los evaluadores.

Conclusiones: El sistema de clasificación de fracturas del pilón tibial alcanza concordancias superiores a las de estudios previos de otras clasificaciones. Dichas concordancias se lograron con médicos con diferentes niveles de experiencia y conocimiento. Nuestros hallazgos contribuyen a la validación externa e independiente de este nuevo sistema de clasificación.
Determinación del grado de agresividad tumoral mediante técnicas de inteligencia artificial aplicadas a imágenes de resonancia magnética
Authors: Segura Facundo , Segura Pablo , Segura Florencio
Published: December 2023

Objetivo: Determinar el grado de agresividad tumoral mediante técnicas de inteligencia artificial utilizando imágenes de resonancia magnética de sarcomas con grado histológico comprobado.

Materiales y Métodos: Dos cohortes retrospectivas independientes de pacientes con sarcomas de partes blandas. Para cada paciente de las dos cohortes se adquirieron tres tipos de secuencias de imágenes como indican los protocolos clínicos: potenciadas en T1, en T2 con supresión grasa (T2FS) y STIR. A fin de desarrollar el modelo de inteligencia artificial, se utilizaron 134 imágenes, tanto las de alto grado como las de bajo grado, en T1 y T2 tomando la imagen más representativa del tumor en cualquier corte. Esto se traduce en 36 millones de píxeles que serán analizados por el programa Landing AI.

Resultados: La precisión promedio del modelo fue del 84,3% y la sensibilidad, del 73,3%, con un umbral de confianza de 0,66, lo que demuestra inicialmente que se obtuvo un modelo de buena calidad para predecir con imágenes de resonancia magnética el grado de agresividad de un sarcoma de partes blandas antes de la biopsia.

Conclusiones: Se presenta un enfoque novedoso para abordar un tipo de enfermedad infrecuente usando técnicas de inteligencia artificial para determinar el grado tumoral en imágenes de resonancia magnética. Según los resultados de nuestro modelo, se lo puede considerar como una segunda opinión experta al realizar los estudios por imágenes antes de la biopsia.
Pinzamiento subcoracoideo: diagnóstico e inyección guiada por ecografía en atletas lanzadores
Authors: Lossada Finol Fernando , Carruyo Avila Julio Alberto
Published: December 2023

El pinzamiento subcoracoideo es un cuadro poco frecuente y, por lo tanto, su diagnóstico plantea un reto al cirujano ortopédico. Se manifiesta con un dolor sordo en la región subcoracoidea y dolor a la palpación en el proceso coracoideo, como resultado del pinzamiento del músculo subescapular entre el proceso coracoideo y el troquín del húmero. El objetivo de esta nota técnica es describir una alternativa diagnóstica y la inyección guiada por ecografía para atletas lanzadores con pinzamiento subcoracoideo.
Transition to Adulthood for Extremely Preterm Survivors
Authors: Pigdon Lauren , Mainzer Rheanna M. , Burnett Alice C. , Anderson Peter J. , Roberts Gehan , Patton George C. , Cheung Michael , Wark John D. , Garland Suzanne M. , Albesher Reem A. , Doyle Lex W. , Cheong Jeanie L.Y. ,   Victorian Infant Collaborative Study Group
Published: December 2023

OBJECTIVE

To compare transition into adulthood of survivors born extremely preterm (EP; <28 weeks’ gestation) or extremely low birth weight (ELBW; <1000 g) in the postsurfactant era with term-born controls.

METHODS

Prospective longitudinal cohort study of all EP/ELBW survivors born in the State of Victoria, Australia between January 1, 1991 and December 31, 1992 and matched term-born controls. Outcomes include educational attainment, employment, financial status, romantic partnering, living arrangements, parenthood, physical health and mental health, risk-taking behaviors, life satisfaction, and interpersonal relationships at 25 years.

RESULTS

Data were available from 165 EP/ELBW and 127 control participants. Overall, there was little evidence for differences between the EP/ELBW and control groups on most comparisons after adjustment for social risk and multiple births. However, compared with controls, the EP/ELBW group was more likely to have their main source of income from government (adjusted odds ratio [aOR] 2.49, 95% confidence interval [CI] 1.21–5.13; P = .01) and to have never moved out of the parental home (aOR 2.13, 95% CI 1.27–3.58; P = .01), and fewer had ever engaged in smoking (aOR 0.52, 95% CI 0.28–0.98; P = .04), binge drinking (aOR 0.41, 95% CI 0.18–0.93; P = .03), or street drugs (aOR 0.56, 95% CI 0.32–0.98; P = .04).

CONCLUSIONS

Aside from clinically important differences in main income source, leaving the parental home, and reduced risk-taking behavior, survivors born EP/ELBW in the era since surfactant was introduced are transitioning into adulthood similarly to term-born controls in some areas assessed but not all.
Questão Ambiental e o uso dos Conhecimentos das Populações Tradicionais
Authors: Gil Nogueira Marinez
Published: December 2023

O presente artigo apresenta resultados de uma pesquisa bibliográfica, que teve como objetivo realizar uma reflexão crítica sobre a relação entre a questão ambiental e a discussão internacional sobre sustentabilidade, evidenciando a partir de acordos multilaterais da globalização econômica a geopolítica internacional de interesses contraditórios defendidos no âmbito da Convenção sobre a Diversidade Biológica (CDB) e o acordo de propriedade intelectual (TRIPS) estabelecido pela Organização Mundial do Comércio (OMC). Entre os principais resultados aponta-se que os princípios de proteção da natureza e dos conhecimentos das populações tradicionais estabelecidos na CDB estão em confronto aos interesses do sistema internacional de propriedade intelectual, mediante a arena de disputa pelo acesso aos recursos da natureza e ao conhecimento das populações tradicionais pela indústria mundial de biotecnologia.
Grandes deleções raras no CFTR
Authors: Montiel Petry Lucas , De Casto e Garcia Laura , Kich Grun Lucas , Da Silva Meneses Amanda , Braga Bittencourt Luana , Puerari Pieta Marina , Van Der Sand Germani `Pedro , Menestrino Prestes Laura , Araujo Pinto Leonardo
Published: December 2023

Objetivo: este trabalho tem como objetivo descrever o diagnóstico e o acompanhamento de pacientes acometidos pelas manifestações da fibrose cística e grandes deleções do gene CFTR. Para isso, realizamos análise retrospectiva de prontuários, incluindo genotipagem e acompanhamento retrospectivo de dados clínicos e de função pulmonar. Descrição dos casos: foram avaliados prontuários eletrônicos e impressos de pacientes acompanhados em ambulatório de referência em fibrose cística. Encontramos três pacientes com grandes deleções no gene CFTR, sendo dois deles heterozigotos (heterozigotos com deleção nos éxons de 2 a 3 e heterozigotos para deleções nos éxons de 25 a 27) e um deles homozigoto (homozigoto para as deleções nos éxons de 19 a 21,). Um paciente apresentou resultado falso negativo no sequenciamento genético completo. Todos os três receberam tratamento padrão para fibrose cística. Dois pacientes morreram de complicações pulmonares da fibrose cística. Portanto, achados falsos negativos no sequenciamento CFTR para o diagnóstico de fibrose cística são raros, mas podem ser mais frequentes em pacientes com grandes deleções. Conclusão: grandes deleções de CFTR estão associadas a fenótipos graves de FC.
Sociedade Brasileira para o Progresso da Ciência nas páginas do jornal Folha de São Paulo no Período Ditatorial (1964-1985)
Authors: Kobayashi Elizabete Mayumy , Papali Maria Aparecida
Published: December 2023

O objetivo deste artigo é analisar como as reuniões anuais da Sociedade Brasileira para o Progresso da Ciência (SBPC) eram apresentadas nas matérias do jornal Folha de São Paulo entre os anos 1964 e 1985, em meio à ditadura militar que assolou o país. As questões principais são qual o destaque dado ao evento pelo jornal e quais os assuntos que ganharam ênfase em meio aos trabalhos apresentados no evento. A escolha desse jornal deve-se ao fato de que era um dos veículos de maior repercussão em São Paulo. O levantamento e análise dessas matérias permitem a elaboração de um mapeamento do posicionamento do jornal em relação às reuniões anuais da SBPC e o valor concedido à cobertura sobre Ciência & Tecnologia em um momento de repressão e de início do processo de redemocratização.
The Development of LED Grow Light for Greenhouse Cultivation
Authors: Kalabkin Alexandr А. , Kuznetsov Evgeniy A. , Ivliyev Sergey N. , Ashryatov Albert A. , Kalabkin Veniamin A. , Musatov Andrey S.
Published: December 2023

Introduction. Lighting is one of the key factors influencing the efficient greenhouse cultivation. In this context, LED grow lights are an innovative solution that allows users to precisely adjust the light parameters necessary for optimal photosynthetic processes.
Aim of the Article. The aim of the work is developing and testing the LED grow light with optimal spectrum and light intensity to ensure efficient growth, development and photosynthesis of plants in greenhouses.
Materials and Methods. The LED grow light was developed in accordance with the regulatory standards that define the basic requirements in light technology for plant growth: GOST R 57671-2017 and GOST R 58461-2019. There is presented the sequence of development stages, according to which this grow light was developed.
Results. As the light source, there was chosen the Full Spectrum-1 LED (China) with two prominent emission peaks at 440 nm and 642 nm. For the grow light, a spotlight housing was selected to direct light precisely onto the plants, thereby ensuring maximum efficiency of photosynthesis and growth. The analysis of ray tracing results in TracePro showed that the LED grow light model has a light distribution close to the cosine type. The radiant flux of emission was 4.14 watts, and the photosynthetic photon flux was 16.6 μmol/s.
Discussion and Conclusion. The developed LED grow light has a photosynthetic photon flux of 16.2 μmol/s at a power consumption of 8.8 watts. The photosynthetic efficiency of the grow light was 1.84 μmol/J. Thus, this grow light can be used for the efficient greenhouse cultivation, providing optimal lighting conditions and contributing to increased crop yield and the quality of agricultural crops.
Scallop bowls from Late Roman Pannonia
Authors: Dévai Kata
Published: December 2023

This paper covers the mould-blown scallop bowls from Late Roman Pannonia (Hungary), which merit a discussion because compared to other regions of the Roman Empire, scallop bowls have a relatively dense distribution in this province (Fig. 6). All the bowls described and discussed here were part of the grave goods recovered from burials, providing a good context for these vessels.
Modelowanie etyczne cyberprzestrzeni z perspektywy osoby. Projekt personalistycznej etyki cyberprzestrzeni
Authors: Kaszuba Paweł
Published: December 2023

This book is an attempt of modelled personal ethics application in order to new cyberspace ethics conditions. The purpose of my monograph is the theoretical construction and the display of personal cyberspace ethics project, which can comprise ethical model of human operations assessment in cyberspace from the human value and dignity perspective. This construction takes into account the current state of the virtual world, shaped by the processes of development of digital technologies. In the book shows to present models of behavioral norms and human operations as a person in an artificial world of technological thought products. The book is theoretical and analytical aproach, which deals with synthetic personal model of cyberspace ethics from the perspective of subject knowledge on the basis of the reference literature, as well as showing ethical challenges and dangers for human in cyberspace based on own empitical analysis performed through observation, focused research, qualitative analysis of cyberspace content and problem discussions. Moreover, in monograph the method of synthesis analysis was assumed, the analysis of available text sources was concluded as well as the method of evaluative analysis was implemented, which deals with media and its contents research. The application of just analytical-theoretical method would be insufficient in order to comprehensive presentation of problematics, that is why the qualitative analysis of cyberspace content was used. The book consists of two parts. In the first part the analysis of available international cyberspace definitions was accessed. The author attempts to systematize concepts in interdisciplinary context. The anthropological and cultural context was also considered, showing the digitize and networking of social relationship processes. In second part the author concentrates on ethical model search, which could determine the basis of universal and comprehensive project of cyberspace ethics. The starting point are sugestions of available regulations, ethical codes as well as attempts of legal, national and international normativity. Personal project of cyberspace ethics seems to be the best and the most universal guarantor of responsible participation in cyberspace.
Cultivos mixtos vs monocultivos, método L.E.R. (Relación equivalente de tierra)
Authors: Bolaños Ramírez Jhonny Kabir , Monje Carvajal Jhon Jairo
Published: December 2023

Los monocultivos generan dependencia a insumos externos, mayor exposición a agro-químicos, deficiencia de nutrientes en los suelos, mayor incidencia de plagas y enfermedades y alteraciones en los ciclos hidrológicos de los territorios. Los cultivos mixtos permiten mejorar los agro ecosistemas y fortalecer las dinámicas socio ambientales y económicas de los productores. El objetivo de la investigación es medir el rendimiento mediante comparación de cultivos mixtos vs monocultivos, utilizando el Método L. E. R. (Relación Equivalente de Tierra) Se utilizaron tres especies: Maíz (Zea mays L.) Fríjol (Phaseolus vulgaris L.) Calabaza (Cucurbita moschata L.) Se fertilizó solamente con un Biol. De los tres tratamientos realizados la asociación de maíz, fríjol y calabaza demostró la mayor producción, donde el maíz produjo 13.888 kg/ha, el fríjol 8888,88 kg/ha y la auyama 8.300 kg/ha. En la otra asociación de maíz y fríjol también superó al monocultivo de maíz en su rendimiento total por hectárea. Se ratificó que los cultivos mixtos tienen un mejor desempeño productivo.
15 primaveras para ojos ávidos y asombros eternos
Authors: Romero Baltodano Andrés
Published: December 2023

En Colombia la actividad de los cine clubes cada vez es más escasa y por eso el Cine Club La Moviola de la Institución Universitaria Politécnico Grancolombiano, sede Bogotá, desde hace quince años exhibe películas que proponen miradas, lenguajes, híbridos, luchas y reflexiones sobre la vida real, irreal y surreal. Esta ponencia comparte la labor que hemos venido desarrollando como cine club con cuidadosas curadurías de los ciclos semestrales, la publicación semestral de un folleto de programación con fichas técnicas y una editorial que soporta cada ciclo, la producción de material audiovisual en series sobre fotógrafos (Francobturador) e ilustradores (Lapizarium), cápsulas radiales sobre directoras de fotografía latinoamericanas (Fotoflash), cápsulas radiales sobre directoras de cine en el mundo (Linternas del Alma), realización de crítica cinematográfica para escribir miradas críticas de la muestra Cortos que van pa’ largo, Pilotos que van pa’l aire, la apertura de un “consultorio” cinematográfico para los docentes de todas las facultades la Moviola Express. Además de todas estas experiencias hemos publicado la Revista Alternativa Multicultural La Moviola que ya llega a su número 116 y se instala sobre temas transversales en arquitectura, teatro, ciencias humanas, literatura, fotografía, cine, música, etc. entrevistas, ensayos sobre películas, reseñas de libros, reseñas de festivales como el Bafici, Venecia, al tiempo que en cada número se invita a un (a) artista plástico para que sea quien muestre un trabajo antológico en la revista.