bluuebunny/crossref_metadata_2025 huggingface dataset:
The consequences of living with a severe malocclusion: A review of the literature
Authors: Leck Richard , Paul Ninu , Rolland Sarah , Birnie David
Published: September 2021

Aim:

To facilitate the orthognathic shared decision-making process by identifying and applying existing research evidence to establish the potential consequences of living with a severe malocclusion.

Methods:

A comprehensive narrative literature review was conducted to explore the potential complications of severe malocclusion. A systematic electronic literature search of four databases combined with supplementary hand searching identified 1024 articles of interest. A total of 799 articles were included in the narrative literature review, which was divided into 10 themes: Oral Health Related Quality Of Life; Temporomandibular Joint Dysfunction; Masticatory Limitation; Sleep Apnoea; Traumatic Dental Injury; Tooth Surface Loss; Change Over Time; Periodontal Injury; Restorative Difficulty; and Functional Shift and Dual Bite. A deductive approach was used to draw conclusions from the evidence available within each theme.

Results:

The narrative literature review established 27 conclusions, indicating that those living with a severe malocclusion may be predisposed to a range of potential consequences. With the exception of Oral Health Related Quality Of Life, which is poorer in adults with severe malocclusion than those with normal occlusions, and the risk of Traumatic Dental Injury, which increases when the overjet is >5 mm in the permanent and 3 mm in the primary dentition, the evidence supporting the remaining conclusions was found to be of low to moderate quality and at high risk of bias.

Conclusion:

This article summarises the findings of a comprehensive narrative literature review in which all of the relevant research evidence within a substantive investigative area is established and evaluated. Notwithstanding limitations regarding the quality of the available evidence; when combined with clinical expertise and an awareness of individual patient preferences, the conclusions presented may facilitate the orthognathic shared decision-making process and furthermore, may guide the development of the high-quality longitudinal research required to validate them.
Mixture models and networks: The stochastic blockmodel
Authors: De Nicola Giacomo , Sischka Benjamin , Kauermann Göran
Published: September 2021

Mixture models are probabilistic models aimed at uncovering and representing latent subgroups within a population. In the realm of network data analysis, the latent subgroups of nodes are typically identified by their connectivity behaviour, with nodes behaving similarly belonging to the same community. In this context, mixture modelling is pursued through stochastic blockmodelling. We consider stochastic blockmodels and some of their variants and extensions from a mixture modelling perspective. We also explore some of the main classes of estimation methods available and propose an alternative approach based on the reformulation of the blockmodel as a graphon. In addition to the discussion of inferential properties and estimating procedures, we focus on the application of the models to several real-world network datasets, showcasing the advantages and pitfalls of different approaches.
Organizational reputation: In search of lost time
Authors: Mariconda Simone , Zamparini Alessandra , Lurati Francesco
Published: September 2021

Organizational reputation has been an important concept in management research for more than 30 years. In this essay, we elaborate on the relationship between the notion of time and organizational reputation. We first review research on reputation in strategic management, highlighting the importance of the construct and how time has traditionally been conceptualized. We then build on existing organizational research on time as a way to advance the understanding of reputation as a more processual and socially constructed phenomenon; we argue that reputation formation, maintenance, and repair could be understood as a form of socio-symbolic work. Based on this foundation, we set out a research agenda providing a path for the investigation of the temporal features of reputation and reputation work.
Seeking input when the train has left the station: The decoupling of participative strategic decision-making processes and the role of new technology in symbolic management
Authors: Westphal James D , Zhu David H , Kunapuli Rajyalakshmi
Published: September 2021

We examine the symbolic management of participative strategic decision-making programs that purportedly use crowdsourcing technology to solicit strategic input below the executive suite, but are often decoupled from actual strategic decision making. Specifically, top management may decide on a strategic option before soliciting input under the program. The first portion of our theoretical framework explains why disclosure of a participative strategic decision making program in communicating with security analysts is associated with more positive analyst appraisals, despite decoupling, and why the benefits of disclosure are amplified to the extent that leaders highlight the use of crowdsourcing technology in the program. The second portion of our framework addresses the antecedents of symbolic adoption. We suggest that firms are more likely to adopt and decouple a program when the CEO has a personal friendship tie to the CEO of another firm that has adopted and decoupled, especially following relatively negative analyst appraisals. Analysis of a unique dataset that includes longitudinal survey data from executives supported our predictions.
Polymorphism in the HaeIII single nucleotide polymorphism of the SLC2A1 gene and cardiovascular disease in the early type 2 diabetes mellitus
Authors: Lee Dong-Hwa , Won Gun Woo , Lee Yong Hee , Shin Jong Sung , Ku Eu Jeong , Oh Tae Keun , Jeon Hyun Jeong
Published: September 2021

Introduction:

SLC2A1 polymorphism may play a role in the smooth muscle cell proliferation and extracellular matrix synthesis in vessels. However, the role of SLC2A1 polymorphism on diabetic cardiovascular disease (CVD) have not yet been identified. In this study, we aimed to investigate the association between SLC2A1 HaeIII polymorphism and CVD in Korean patients with type 2 diabetes mellitus (T2DM) according to disease duration.

Methods:

A total of 846 patients with T2DM who visited the Chungbuk National University Hospital were investigated. The HaeIII polymorphism of SLC2A1 gene was determined by real time polymerase chain reaction method. Genotyping results were presented GG, AG, or AA. Subgroup analysis was performed according to duration of T2DM (⩽10, 11–20, >20 years).

Results:

The AA genotype was significantly associated with higher prevalence of CVD in patients with DM duration less than 10 years (26.3% vs 9.2%, p = 0.014). There was no significant association between SLC2A1 HaeIII polymorphism and other diabetic complications including, retinopathy, nephropathy, neuropathy, cerebrovascular disease, and peripheral artery disease.

Conclusions:

The SLC2A1 HaeIII polymorphism was associated with CVD in Korean patients with T2DM with short disease duration.
The Politics of the President’s Immigration Rhetoric
Authors: Eshbaugh-Soha Matthew , Juenke Eric Gonzalez
Published: September 2021

Although research on immigration politics is extensive, few scholars have systematically connected immigration politics to the president’s rhetoric over time. This is surprising since all modern presidents have referenced immigration in their public statements and presidents play a central role in setting the policy agenda. The primary purpose of this paper is to explain the president’s immigration rhetoric since 1953. Thus, we collect all presidential speeches on immigration through the Obama Administration, calculating the president’s monthly attention to immigration, and the relative negativity of the president’s remarks. We theorize that presidents’ motivation to speak about immigration policy is driven by the attention others devote to immigration policy, and key interventions in the immigration policy debate. Rhetorical tone, we think, is a function of the changing policy definition of immigration generated by Prop 187 and the Post-911 era. Our results show that the content of presidential rhetoric on immigration is indeed a product of these factors, providing us with clear evidence as to when the president devotes public attention to one of the central issues of American politics.
Necrotizing Fasciitis and Diabetic Foot: Results of a Prompt Identification, Surgery and Antibiotic Therapy (P.I.S.A.) Protocol
Authors: Iacopi Elisabetta , Sbarbaro Catia , Pieruzzi Letizia , Lorenzi Irene , Baroni Luisa , Goretti Chiara , Malacarne Paolo , Piaggesi Alberto
Published: September 2021

Necrotizing fasciitis (NF) is a rapidly progressive, life-threatening infection, involving the skin, soft tissue and fascia. We evaluated outcomes of its surgical management in diabetic foot (DF) patients in a tertiary referral centre. We retrospectively searched for NF in the database of our DF Section from 2016 to 2018. All cases were treated according to a multiprofessional integrated protocol, with Prompt Identification, Surgical debridement and systemic Antibiotic therapy (P.I.S.A. Protocol). We analysed short-term evolution (surgical procedures and major amputations), and long-term outcomes (survival and healing rates). Sixty-eight patients were referred to our DF clinic for suspicion of NF. The diagnosis was confirmed in 54 (79.4%; male/female 40/14; type 1/2 diabetes 6/48; age 62.8 ± 8.1 years; duration of diabetes 13.6 ± 10.1 years). According to the microbiological results, cases were classified as Type 1 (33–61.2%), 2 (7−12.9%) and 3 (14–25.9%). No significant differences were observed. All patients underwent a decompressive fasciotomy. Six patients (11.1%) required also a forefoot amputation and 12 (22.2%) a toe or ray amputation. No major amputation was performed in the short-term period. During the follow-up (26 ± 12 months) 46 patients (85%) healed in 94 ± 11 days. Of the remaining 8: 5 (9.2%) died for other reasons before healing, 2 (3.7%) recurred and one (1.9%) required a major amputation. Our experience reveals a relatively high prevalence of NF in DF; despite this, we observed how, when promptly and aggressively treated, NF has a good prognosis and it is not associated with an excess of limb loss and deaths.
Clinical and Economic Outcomes of Using Robotic Versus Hand-Held Staplers During Robotic Lobectomy
Authors: Zervos Michael , Song Alfred , Li Yanli , Lee Shih Hao , Oh Daniel S.
Published: September 2021

Objective

During robotic lobectomy (RL), the surgeon can elect to use either robotic staplers or hand-held laparoscopic staplers. It is assumed that either will result in similar outcomes, while robotic staplers increase cost. We sought to compare perioperative outcomes and costs between RL cases that utilized robotic staplers versus hand-held staplers in real-world clinical practice.

Methods

Patients who underwent an elective RL between October 2015 and December 2017 were identified in the Premier Hospital Perspective Database. Propensity score matching (PSM) analysis was performed to compare perioperative outcomes, healthcare resource utilization, and costs between cases using robotic staplers and hand-held staplers during RL.

Results

In the PSM analysis, RL cases that fully utilized robotic staplers compared to hand-held staplers were associated with significantly lower risks of developing bleeding (5.6% vs 9.8%, P = 0.03) and conversion to open surgery (0.3% vs 5.9%, P = 0.004). Additionally, in a multivariable regression analysis, robotic stapler was associated with reduced risk for air leak (OR 0.70, 95% CI 0.50–0.98) and overall complications (OR 0.76, 95% CI 0.58–0.99). The total index hospitalization costs were comparable between the 2 groups (median [IQR], $21,667 [$16,860–$29,033] in robotic stapler vs $21,398 [$17,258–$29,406] in hand-held stapler, P = 0.22).

Conclusions

Among RL cases, utilization of robotic staplers was associated with significantly lower risks of perioperative bleeding, conversion, and possibly air leak and overall complications compared to RL cases utilizing hand-held staplers. The choice of stapler may have an impact on outcomes and robotic staplers do not increase total costs.
Prognostic Value of Red Blood Cell Distribution Width in Transcatheter Aortic Valve Replacement Patients
Authors: Aalaei-Andabili Seyed Hossein , Anderson R. David , Bavry Anthony A. , Barr Brian , Arnaoutakis George J. , Beaver Thomas M.
Published: September 2021

Objective

Elevated red blood cell distribution width (RDW) level has been shown to be associated with poor outcomes in patients with cardiovascular disease. Limited data are available regarding the prognostic value of RDW in transcatheter aortic valve replacement (TAVR) patients. Therefore, we aimed to investigate the impact of RDW variation on outcomes of TAVR patients.

Methods

From March 20, 2012, to February 20, 2020, the pre-TAVR RDW levels of 1,163 consecutive TAVR patients were examined. Receiver operating curves were set to define the most accurate cut-point, which was subsequently validated in our validation set. Associations of RDW levels with early and long-term outcomes were investigated.

Results

A total of 988 patients were eligible for the analysis. Patients with 30-day, 1-year, and 7-year mortality had significantly higher pre-TAVR RDW levels (15.8% [12.9-19.1] vs 14.7% [11.6-26.3], P = 0.01; 16% [12.3-26.3] vs 14.7% [11.6-24.3], P < 0.001; 15.6% [12.3-26.3] vs 14.6% [11.6-24.3], P < 0.001, respectively). A RDW of 14.5% was found as the most sensitive and specific cut-point for mortality at 1 and 7 years (HR = 2.6, 95% CI: 1.6-4.2, P < 0.001; HR = 1.8, 95% CI: 1.3-2.4, P < 0.001), with mortality of 22% versus 10% at 1 year ( P < 0.001) and 37% versus 27% at 7 years ( P < 0.001) in patients with RDW ≥14.5% versus those with RDW <14.5%.

Conclusions

RDW is an important prognostic factor in TAVR patients. A RDW level higher than 14.5% is significantly associated with post-TAVR early and late mortality. RDW levels should be incorporated into current risk assessment models as an additional variable to predict post-TAVR outcomes.
Posttraumatic Arthritis After Combined Plating of Distal Radius Fractures AO Type C: A 7-Year Follow-up of 97 Cases
Authors: Lundqvist Eva , Fischer Per , Wretenberg Per , Krauss Wolfgang , Sagerfors Marcus
Published: September 2021

Background:

Volar locking plate fixation is the most common method of operative fixation of distal radius fractures (DRFs). For more complex cases, combined plating is an option for stabilizing intra-articular fragments. The prevalence of posttraumatic arthritis (PA) after an intra-articular DRF, and its relation to patient-reported outcome measures (PROMs), remains unclear. The purpose of this study was to study the prevalence of PA and its correlation to clinical outcome measures.

Methods:

We evaluated 97 consecutive patients with intra-articular DRF, operated with combined plating, 7 years postoperatively. The primary outcome measure was the prevalence of radiographic PA. Secondary outcome measures included visual analog scale (VAS) pain score, hand grip strength, wrist range of motion (ROM), Patient-Rated Wrist Evaluation (PRWE) score, and Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) score. Radiographic examination was performed between 1 and 7 years postoperatively.

Results:

The prevalence of PA was 29% at the 7-year follow-up. No correlation was found between PA and ROM, hand grip strength, PRWE, QuickDASH, VAS pain scores, or radiographic reduction. Median wrist ROM and grip strength were significantly inferior compared with the uninjured side. Hardware removal was performed in 51.5% of cases. There were 2 cases of tendon ruptures.

Conclusions:

Combined plating can yield a good clinical outcome 7 years postoperatively and a low prevalence of PA. The presence of PA did not correlate to clinical outcome measures or to the accuracy of anatomical reduction 1 year postoperatively. The frequency of tendon ruptures was acceptable, but the high frequency of hardware removal is a concern.
Static and dynamic evaluation of a butterfly-shaped concrete-filled steel tube arch bridge through numerical analysis and field tests
Authors: Wu Gang , Ren Wei-Xin , Zhu Ya-Fei , Hussain Syed M
Published: September 2021

The butterfly-shaped concrete-filled steel tube (CFST) arch bridge is an irregular bridge with unique esthetics. In this paper, this new shape of CFST arch bridge is introduced, and a refined three-dimensional finite element model (FEM) is established to evaluate static and dynamic behavior of the bridge. In order to reduce model errors, the FEM is calibrated according to numerical analysis and field tests. Static calculation results show that the butterfly-shaped bridge has good structural performance. The bending moment and axial force of the arch ribs increase when the camber angle of suspender changing from 15° to 50°. Dynamic test is carried out by ambient vibration testing under traffic and wind-induced excitations. The modal parameters of the bridge were calculated by the stochastic subspace identification method in the time domain. In terms of natural frequencies and mode shapes, the FEM analysis was validated by experimental modal analysis. The updated model thus obtained can be treated as a baseline finite element model, which is suitable for long term monitoring and safety evaluation of the structure in different severe circumstances such as earthquakes and wind loading in future.
Estimating the effects of trait knowledge on social perception
Authors: Wildman Andrew , Ramsey Richard
Published: September 2021

Research in social cognition has predominantly investigated perceptual and inferential processes separately; however, real-world social interactions usually involve integration between person inferences (e.g., generous, selfish) and the perception of physical appearance (e.g., thin, tall). Therefore, in the current work, we investigated the integration of different person-relevant signals, by estimating the extent to which bias in one social information processing system influences another. Following an initial stimulus-validation experiment (Experiment 1, N = 55), two further pre-registered experiments (Experiments 2, N = 55 and 3; N = 123) employed a priming paradigm to measure the effects of extraversion-diagnostic information on subsequent health and body-size judgements of a target body. The results were consistent across both priming experiments and supported our predictions: compared to trait-neutral control statements, extraversion-diagnostic statements increased judgements of health and decreased those of body size. As such, we show that trait-based knowledge does not only influence mappings towards similar types of person judgements, such as health judgements. Rather, even a brief re-configuration of trait-space alters mappings towards non-trait judgements, which are based on body size and shape. The results complement prior neuroimaging findings that showed functional interactions between the body-selective brain regions in the ventral visual stream and the theory of mind network when forming impressions of others. Therefore, we provide a functional signature of how distinct information processing units exchange signals and integrate information to form impressions. Overall, the current study underscores the value of behavioural work in complementing neuroscience research when investigating the role and properties of functional integration during impression formation. In addition, it stresses the potential limitations of an over-reliance on studying separate systems in isolation.
(Mis)communication through stickers in online group discussions: A multiple-case study
Authors: Tang Ying , Hew Khe Foon , Herring Susan C. , Chen Qian
Published: September 2021

Sticker use is an increasingly popular part of daily messaging activity. However, little is known regarding the types, functions, and outcomes of sticker use in authentic online communications. To investigate these phenomena, we analysed sticker use in five small mobile-messaging-facilitated discussion groups initiated by students for course projects in an Asian university. The students used four types of stickers, among which ‘animated picture without text’ was the most frequent. Sticker functions fell into two main categories: as a tone indicator with scope over a textual message, and as a stand-alone illocutionary act. Based on interviews with seven participants, we found disparities between the sender’s intention and the receiver’s interpretation for 34.7% of the stickers, but these disparities did not adversely affect the communication. Implications of the findings are discussed.
How Do Basic Personality Traits Map Onto Moral Judgments of Fairness-Related Actions?
Authors: Andrejević Milan , Smillie Luke D. , Feuerriegel Daniel , Turner William F. , Laham Simon M. , Bode Stefan
Published: September 2021

Reliance on fairness norms is a core feature of moral behavior and judgment, and is conceptually and empirically linked with basic personality dimensions. However, the specific nature of these links is poorly understood. In this study ( N = 313, 68% female), we employed a novel third-party judgment paradigm, in which participants made moral judgments of various sharing actions of virtual others. This allowed us to capture individual variation in the relative importance of several fairness norms. We correlated these norm profiles with Big Five personality traits. We observed distinct associations between agreeableness, conscientiousness, openness, and extraversion and estimates of the importance of generosity, selfishness, relative generosity, and relative selfishness norms. Comparisons of these associations at the domain- versus facet-level of personality traits suggested these relations are specific to domain-level traits. These findings are an important step toward unraveling the complex links between fairness norms and basic personality traits.
Autoimmune diseases of the brain, imaging and clinical review
Authors: Shadmani Ghazal , Simkins Tyrell J , Assadsangabi Reza , Apperson Michelle , Hacein-Bey Lotfi , Raslan Osama , Ivanovic Vladimir
Published: September 2021

There is an extensive spectrum of autoimmune entities that can involve the central nervous system, which has expanded with the emergence of new imaging modalities and several clinicopathologic entities. Clinical presentation is usually non-specific, and imaging has a critical role in the workup of these diseases. Immune-mediated diseases of the brain are not common in daily practice for radiologists and, except for a few of them such as multiple sclerosis, there is a vague understanding about differentiating them from each other based on the radiological findings. In this review, we aim to provide a practical diagnostic approach based on the unique radiological findings for each disease. We hope our diagnostic approach will help radiologists expand their basic understanding of the discussed disease entities and narrow the differential diagnosis in specific clinical scenarios. An understanding of unique imaging features of these disorders, along with laboratory evaluation, may enable clinicians to decrease the need for tissue biopsy.
Simplified calculation of airblast variability and reliability-based design load factors for spherical air burst and hemispherical surface burst explosions
Authors: Stewart Mark G
Published: September 2021

There can be significant uncertainty and variability with explosive blast loading. Standards and codes of practice are underpinned by reliability-based principles, and there is little reason not to apply these to explosive blast loading. This paper develops a simplified approach where regression equations may be used to predict the probabilistic model of airblast variability and associated reliability-based design load factors (or RBDFs) for all combinations of range, explosive mass and model errors. These models are applicable to (i) hemispherical surface bursts, and (ii) spherical free-air bursts. The benefit of this simplified approach is that the equations can be easily programed into a spreadsheet, computer code or other numerical methods. There is no need for any Monte-Carlo or other probabilistic calculations. Examples then illustrate how model error, range and explosive mass uncertainty and variability affect the variability of pressure and impulse, which in turn affect the damage assessment of residential construction.
Correlates of post-dural puncture headache and efficacy of different treatment options: a monocentric retrospective study
Authors: Azzi Akel , Saliba Elie , Stephan Jean-Claude , Saba Hala , Hallit Souheil , Chamandi Souheil
Published: September 2021

Background:

Post-dural puncture headache (PDPH) is a severe positional headache that appears usually within 72 hours after inadvertent dural puncture, secondary to cerebrospinal fluid leakage. It is treated first by conservative treatment (including bed rest, hydration, caffeine and simple analgesia) and then by invasive procedures such as blood patch. This study aims to evaluate factors associated with PDPH among a sample of Lebanese patients and assess the rate of success of different treatment modalities administered in a specific sequence: conservative treatment first, then ultrasound-guided bilateral greater occipital nerve block (GONB) if failure of conservative treatment and finally epidural blood patch (EBP) if failure of GONB.

Methods:

A retrospective case–control study was conducted between January 2015 and December 2019 in the Notre-Dame des Secours University Hospital. Out of a total of 10,051 procedures, 18 cases were diagnosed with PDPH and were matched based on gender, age and procedure type to a control group of patients who did not develop PDPH randomly selected (72 patients).

Results:

Higher body mass index (adjusted odds ratio (ORa) = 0.77) was significantly associated with lower odds of PDPH, whereas the presence of previous chronic headache (ORa = 5.56) was significantly associated with higher odds of PDPH. Seven out of 18 (38.89%) had their pain symptoms/headache resolved on conservative treatment. Out of the remaining 11 patients, 6 (33.33%) had their symptoms resolved on GONB with a significant decrease in the pain score 48 hours after GONB compared to baseline (5.55 vs 9.73; p = 0.007). Five patients (27.78%) had their symptoms resolved using a blood patch, with a significant decrease in the pain score after blood patch compared to baseline (3.00 vs 9.80; p = 0.041).

Conclusion:

Our preliminary data suggest that ultrasound-guided GONB is a minimally risky and efficacious technique for those who fail to respond to conservative treatment.
Term or Phrase Usage and Contextual Meaning: A Reexamination of Semantic Issues in Translation
Authors: Bascom Robert
Published: September 2021

It has been observed that “words do not have meanings but rather meanings have words.” But even more, words and phrases, usually thought of as the basic units of meaning, actually should be seen as having only usages within contexts. These contexts themselves are the elements of communication that activate mental and bodily states and processes, and can be properly thought of as the construal of meaning. Sometimes these contexts of usage are shaped by phonological or grammatical patterns (see B. Bergen), sometimes by sociological factors such as reciprocity (see E. Goffman), and of course most commonly by lexical (usually radial) patterns and categories (traditionally presented as “semantic domains”). Cognitive linguists (e.g., Lakoff, Turner) have been hinting at something like this for a long time, but a clear restatement of what constitutes semantics is overdue.
The Sign Language Bible Translation Movement: A Look through the Eyes of TBT
Authors: Penner Mark
Published: September 2021

In this article I look at articles in past issues of The Bible Translator to note what they say about sign language Bible translation (SLBT) and to highlight areas of particular importance to today’s SLBT movement. After a summary and some updates on the history of the movement, I look at the various issues raised in the articles about SLBT work, covering topics such as Deaf identity, issues surrounding sign language, the need for Deaf ownership, setting up SLBT projects, and the process of translation.
The Good News Bible as a Model Text for Other Translations
Authors: Suee Yan Yu
Published: September 2021

Since its publication and subsequent revisions, the Good News Bible (GNB) has remained popular among certain segments of the population, used by millions of people. It often serves as a model text for Bible translation projects in various parts of the world that adopt the functional equivalence approach, with far-reaching consequences. This article begins with a brief overview of GNB, examines some issues pertaining to using GNB as a model text, and highlights some areas where GNB could be adapted and localized to better serve the needs of the intended users.
Bible Translation as Incarnation of the Word of God: Transformational Power through Form and Meaning
Authors: Winedt Marlon
Published: September 2021

Bible translation is not a neutral activity, divested of any moral, spiritual, or cultural claim or responsibility. Form has often distorted meaning but happily meaning has often created new hybrid forms in different cultures. This paper addresses the need to work out the incarnational aspect of Bible translation in terms of a conscious multimodal perspective. First, there is a need for a philosophical-theological account of the dialectical relationship between form and meaning. Second, we need to reinterpret the relationship among different types of embodied performance, such as oral and written translation, as part of the same multimodal reality. Finally, Bible translation should promote the appropriation of Scripture through the community’s culture in different forms in order to unleash its transformational power. Multimodal theory can offer a valuable tool to treat all types and modes of translation as equal, but distinct, expressions, thus acknowledging different cultures, people groups, and communities of faith.
Algorithmic Closeness in Mourning: Vernaculars of the Hashtag #grief on TikTok
Authors: Eriksson Krutrök Moa
Published: September 2021

This study looks at how mourning is expressed using the hashtag #grief on the social media app TikTok using qualitative content analysis. In a dataset of 100 TikTok videos, this article explores how the TikTok ranking algorithms, which orders content based on previous user engagements, may connect people in mourning across the platform and how these platform-enabled interactions may shape grief expressions. The study shows how grief was narrated on TikTok, which sociotechnical templates (such as duets, stitches, and audios) were incorporated into such expressions, and how these expressions of grief challenged societal mourning norms. This article ends with a discussion about how different subcultural norms on TikTok are linked to the way in which ranking algorithms create social connections across the platform. This study proposes that the “algorithmic closeness” of TikTok users in grief allows them to challenge societal mourning norms in imagined safe spaces, shaped by the algorithmic ranking systems on the platform.
Patients’ Experiences of “Long COVID” in the Community and Recommendations for Improving Services: A Quality Improvement Survey
Authors: Razai Mohammad Sharif , Al-Bedaery Roaa , Anand Laxmi , Fitch Katherine , Okechukwu Hannah , Saraki Teniola M. , Oakeshott Pippa
Published: September 2021

Introduction:

“Long COVID” is a multisystem disease that lasts for 4 or more weeks following initial symptoms of COVID-19. In the UK, at least 10% of patient report symptoms at 12 weeks following a positive COVID-19 test. The aims of this quality improvement survey were to explore patients’ acute and post-acute “long” COVID-19 symptoms, their experiences of community services and their recommendations for improving these services.

Methods:

Seventy patients diagnosed with COVID were randomly selected from 2 large socially and ethnically diverse primary care practices. Of those contactable by telephone, 85% (41/48) agreed to participate in the quality improvement survey. They were interviewed by telephone using a semi-structured questionnaire about community services for COVID-19 patients. Interviews lasted 10 to 15 minutes.

Results:

Forty-nine percent of patients reported at least 1 post-acute COVID-19 symptom. The most common were severe fatigue (45%), breathlessness (30%), neurocognitive difficulties (such as poor memory), poor concentration and “brain fog” (30%), headaches (20%), and joint pain (20%). Many patients felt isolated and fearful, with scant information about community resources and little safety netting advice. Patients also expected more from primary care with over half (56%) recommending regular phone calls and follow up from healthcare staff as the most important approach in their recovery.

Conclusions:

In line with patients’ requests for more support, the practices now routinely refer patients with long COVID to an on-site social prescriber who explores how they are getting on, refers them to the GP or practice nurse when required, and sign posts them to support services in the community.
Location Choice of a Partially–Private Monopoly Supplier
Authors: Lingga Doriani , Simanjuntak Damiana
Published: September 2021

This paper analyzes the location choice of an upstream monopolist who supplies input to asymmetric duopoly firms in a downstream market. The monopolist is partially private, in that it cares not only about its profit maximization but also about the survival of the downstream firms. Based on the Hotelling model, we find that the monopolist is always attracted to locate closer to the efficient downstream firm. In particular, when the efficiency difference between the two downstream firms is not too high, such that no firm is driven out of the market, the monopolist locates at a distance of 1/6 from the efficient firm in the line segment of unit length. Finally, considering the downstream firms’ survival, we show that the upstream monopolist charges a higher input price on the efficient firm. This study may be relevant to the product differentiation framework, in which firms can benefit from producing goods that are close to the preference of high-type consumers; to the pharmaceutical industry, in which pharmacy companies must cover a broad market segment; or to the policymaking process, in which policymakers may have an incentive to make a policy preferred by a particular group of the society.

JEL Classifications: D42, L12, L230
First, Do No Harm: Understanding Primary Care Providers’ Perception of Risks Associated With Discussing Weight With Pediatric Patients
Authors: Loth Katie A. , Lebow Jocelyn , Uy Marc James Abrigo , Ngaw Samantha M. , Neumark-Sztainer Dianne , Berge Jerica M.
Published: September 2021

Many health care providers struggle with if- and how-to discuss weight with their pediatric patients. This study used one-on-one interviews with primary care providers (n = 20) to better understand their: (1) perception of risks associated with talking about weight with pediatric patients, (2) commitment to adhering to best practices of pediatric weight management, and (3) approaches to mitigate perceived risks. Providers felt concerned that discussing weight with children during clinic visits may have unintended negative impacts. Despite perceived risks, providers continued regular BMI screening and weight-focused conversations, but took care with regard to language and approach with the goal of mitigating perceived risks. Findings suggest that pediatric primary care providers perceive that engaging in weight-related discussions with their patients has the potential to lead to negative, unintended consequences. Future research is needed to understand if weight-focused conversations should be avoided altogether or if there are approaches that can effectively mitigate risks.
Age-specific cerebral haemodynamic effects of early blood pressure lowering after transient ischaemic attack and non-disabling stroke
Authors: Mazzucco Sara , Li Linxin , McGurgan Iain J , Tuna Maria A , Brunelli Nicoletta , Binney Lucy E , Rothwell Peter M ,   on behalf of the Oxford Vascular Study Phenotyped cohort
Published: September 2021

Introduction

There is limited knowledge of the effects of blood pressure (BP) lowering on cerebral haemodynamics after transient ischaemic attack (TIA) and non-disabling stroke, particularly at older ages. We aimed to evaluate changes in transcranial Doppler (TCD) haemodynamic indices in patients undergoing early blood pressure lowering after TIA/non-disabling stroke, irrespective of age.

Patients and methods

Among consecutive eligible patients attending a rapid-access clinic with suspected TIA/non-disabling stroke and no evidence of extra/intracranial stenosis, hypertensive ones underwent intensive BP-lowering guided by daily home telemetric blood pressure monitoring (HBPM). Clinic-based BP, HBPM, End-tidal CO2 and bilateral middle cerebral artery (MCA) velocity on TCD were compared in the acute setting versus one-month follow-up; changes were stratified by baseline hypertension (clinic-BP≥140/90) and by age (<65, 65–79 and ≥80).

Results

In 697 patients with repeated TCD measures, mean/SD baseline systolic-BP (145.0/21.3 mmHg) was reduced by an average of 11.3/19.9 mmHg ( p < 0.0001) at one-month (133.7/17.4 mmHg), driven by patients hypertensive at baseline (systolic-BP change = −19.0/19.2 mmHg, p < 0.001; vs −0.5/15.4, p = 0.62 in normotensives). Compared with baseline, a significant change was observed at one-month only in mean/SD MCA end diastolic velocity (EDV) (0.77/7.26 cm/s, p = 0.005) and in resistance index (RI) (−0.005/0.051, p = 0.016), driven by hypertensive patients (mean/SD EDV change: 1.145/6.96 cm/s p = 0.001, RI change −0.007/0.06, p = 0.014). Findings were similar at all ages (EDV change – ptrend=0.357; RI change – ptrend=0.225), including 117 patients aged ≥80. EDV and RI changes were largest in 100 patients with clinic systolic-BP decrease ≥30 mmHg (mean/SD EDV change = 2.49/7.47 cm/s, p = 0.001; RI change −0.024/0.063, p < 0.0001).

Conclusion

There was no evidence of worsening of TCD haemodynamic indices associated with BP-lowering soon after TIA/non-disabling stroke, irrespective of age and degree of BP reduction. In fact, EDV increase and RI decrease observed after treatment of hypertensive patients suggest a decrease in distal vascular resistance.
Dry Needling for the Treatment of Musculoskeletal Ailments With Trigger Points
Authors: Padanilam Simon J. , Dayton Steven R. , Jarema Ryan , Boctor Michael J. , Tjong Vehniah K.
Published: September 2021

Background:

Dry needling is an increasingly popular technique for relieving musculoskeletal pain, through targeting myofascial trigger points. Existing evidence indicates that dry needling is effective in short-term management of pain, with research showing efficacy in improving functional outcomes when compared to other treatments.

Indications:

Myofascial trigger points may result in range of motion limitations and muscle weakness. Noninvasive treatments for musculoskeletal pain associated with myofascial trigger points, such as stretching or warm compresses, may not provide significant benefit for patients. Dry needling is a minimally invasive technique that provides significant short-term functional improvement and analgesia for musculoskeletal pain associated with myofascial trigger points, seen with reductions in visual analog scale (VAS) pain scores and decreased need for pharmacologic therapies.

Technique Description:

This video demonstrates dry needling at the tensor fascia latae, extensor carpi radialis longus, and gastrocnemius muscles. Myofascial trigger points and important anatomical landmarks are identified and labeled. A needle is inserted into the region of the myofascial trigger point to a depth of 10 to 100 mm and remains in situ for about 10 to 20 seconds with the use of a piston technique, although this time varies dependent upon patient response.

Results:

Dry needling may significantly decrease pain and improve functional outcomes in patients with short-term musculoskeletal ailments. Randomized controlled trials have examined dry needling for fibromyalgia, mechanical neck pain, myofascial pain, and following total knee arthroplasty, with these finding significant reductions in pain scores in short-term follow-up. A randomized single-blind placebo-controlled trial found dry needling with exercise to be more effective than sham dry-needling and exercise. Dry needling may provide improved long-term analgesia but also results in increased pain during the procedure and increased soreness afterwards. Pain relief may not last beyond 6 months, although little research investigating long-term outcomes has been performed.

Discussion/Conclusion:

The usage of dry needling in clinical settings is increasing, as it has shown strong efficacy in providing short-term pain relief and ability to improve functional outcomes. Dry needling is a simple, minimally invasive technique that is easily and quickly learned by physical therapists and may provide great benefits to patients.
Clinical features, pathophysiology, and therapy of poor graft function post–allogeneic stem cell transplantation
Authors: Prabahran Ashvind , Koldej Rachel , Chee Lynette , Ritchie David
Published: September 2021

Poor graft function (PGF), defined by the presence of multilineage cytopenias in the presence of 100% donor chimerism, is a serious complication of allogeneic stem cell transplant (alloSCT). Inducers or potentiators of alloimmunity such as cytomegalovirus reactivation and graft-versus-host disease are associated with the development of PGF, however, more clinical studies are required to establish further risk factors and describe outcomes of PGF. The pathophysiology of PGF can be conceptualized as dysfunction related to the number or productivity of the stem cell compartment, defects in bone marrow microenvironment components such as mesenchymal stromal cells and endothelial cells, or immunological suppression of post-alloSCT hematopoiesis. Treatment strategies focused on improving stem cell number and function and microenvironment support of hematopoiesis have been attempted with variable success. There has been limited use of immune manipulation as a therapeutic strategy, but emerging therapies hold promise. This review details the current understanding of the causes of PGF and methods of treatment to provide a framework for clinicians managing this complex problem.
SwarmTCR: a computational approach to predict the specificity of T cell receptors
Authors: Ehrlich Ryan , Kamga Larisa , Gil Anna , Luzuriaga Katherine , Selin Liisa K. , Ghersi Dario
Published: September 2021

Background

With more T cell receptor sequence data becoming available, the need for bioinformatics approaches to predict T cell receptor specificity is even more pressing. Here we present SwarmTCR, a method that uses labeled sequence data to predict the specificity of T cell receptors using a nearest-neighbor approach. SwarmTCR works by optimizing the weights of the individual CDR regions to maximize classification performance.

Results

We compared the performance of SwarmTCR against another nearest-neighbor method and showed that SwarmTCR performs well both with bulk sequencing data and with single cell data. In addition, we show that the weights returned by SwarmTCR are biologically interpretable.

Conclusions

Computationally predicting the specificity of T cell receptors can be a powerful tool to shed light on the immune response against infectious diseases and cancers, autoimmunity, cancer immunotherapy, and immunopathology. SwarmTCR is distributed freely under the terms of the GPL-3 license. The source code and all sequencing data are available at GitHub (https://github.com/thecodingdoc/SwarmTCR).
Reproducibility of mass spectrometry based metabolomics data
Authors: Ghosh Tusharkanti , Philtron Daisy , Zhang Weiming , Kechris Katerina , Ghosh Debashis
Published: September 2021

Background

Assessing the reproducibility of measurements is an important first step for improving the reliability of downstream analyses of high-throughput metabolomics experiments. We define a metabolite to be reproducible when it demonstrates consistency across replicate experiments. Similarly, metabolites which are not consistent across replicates can be labeled as irreproducible. In this work, we introduce and evaluate the use (Ma)ximum (R)ank (R)eproducibility (MaRR) to examine reproducibility in mass spectrometry-based metabolomics experiments. We examine reproducibility across technical or biological samples in three different mass spectrometry metabolomics (MS-Metabolomics) data sets.

Results

We apply MaRR, a nonparametric approach that detects the change from reproducible to irreproducible signals using a maximal rank statistic. The advantage of using MaRR over model-based methods that it does not make parametric assumptions on the underlying distributions or dependence structures of reproducible metabolites. Using three MS Metabolomics data sets generated in the multi-center Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPD) study, we applied the MaRR procedure after data processing to explore reproducibility across technical or biological samples. Under realistic settings of MS-Metabolomics data, the MaRR procedure effectively controls the False Discovery Rate (FDR) when there was a gradual reduction in correlation between replicate pairs for less highly ranked signals. Simulation studies also show that the MaRR procedure tends to have high power for detecting reproducible metabolites in most situations except for smaller values of proportion of reproducible metabolites. Bias (i.e., the difference between the estimated and the true value of reproducible signal proportions) values for simulations are also close to zero. The results reported from the real data show a higher level of reproducibility for technical replicates compared to biological replicates across all the three different datasets. In summary, we demonstrate that the MaRR procedure application can be adapted to various experimental designs, and that the nonparametric approach performs consistently well.

Conclusions

This research was motivated by reproducibility, which has proven to be a major obstacle in the use of genomic findings to advance clinical practice. In this paper, we developed a data-driven approach to assess the reproducibility of MS-Metabolomics data sets. The methods described in this paper are implemented in the open-source R packagemarr, which is freely available from Bioconductor athttp://bioconductor.org/packages/marr.