bluuebunny/crossref_metadata_2025 huggingface dataset:
Pricing the bridewealth: On moral embedding in the mechanism of rural betrothal gifts negotiation—case analysis based on L County, Gansu Province
Authors: Wang Sining , Jia Yujing , Tian Geng
Published: February 2022

Bridewealth is both a monetary as well as a cultural component of Chinese marriage. Existing research employs two major frames to examine this phenomenon: marriage market theory and gift flow theory. However, neither of them ably facilitates the study of bridewealth as a social process, namely, the negotiations that take place between senior family members representing the engaged parties to decide the appropriate monetary value of the bridewealth. This article focuses on how the negotiations are initiated and progress until both families settle on a “decent” bridewealth amount. The ultimate ethical code in relation to marriage-making lies not so much in the mutual understanding of the two families as in their strategies to follow the moral sanctions of the dahang while negotiating a price that deviates from it. The necessity of adhering to the dahang and the strategic efforts to morally legitimize a price that fluctuates from it are central to theorizing the normative embeddedness of bridewealth in the moral fabric of the community.
Quilombos in Brazil and the Americas: Black Resistance in Historical Perspective
Authors: Maria da Silva Givânia , Souza Bárbara Oliveira
Published: February 2022

This article provides a historical overview of the struggles and organizational processes of rural black, or Afro-rural, communities in Brazil and the Americas, variably known in local nomenclatures as quilombos, mocambos, palenques, cumbes, cimarrones, and maroons. The objective is to clarify who these communities are and how they were formed in Brazil and the Americas. The study is based on research with rural black community leaders, their accounts, and their experience. It shows that processes of resistance to slavery and oppression induced the formation of Afro-rural communities, leading to their recognition in national constitutions.
Capitalism and Racism in theLongue Durée: An Analysis of Their Reflexive Determinations
Authors: Góes Weber Lopes , Faustino Deivison M.
Published: February 2022

The genesis of racism, its specific features, conceptual boundaries, and position within capitalist relations of production have been widely discussed. Although there is no consensus as to what came first, and neither as to what prevails in the complex and relational dynamics of social reproduction, there is a general agreement that racism is a multidimensional phenomenon that combines group discrimination and hierarchization, guided by naturalized assumptions and supposedly inherent differences. This study examines the historical features of several racist theories to provide a more accurate view of the reflexive determinations between capitalism and racism.
Impact of COVID-19 Outbreak on the Stock Market: An Evidence from Select Economies
Authors: Ganie Irfan Rashid , Wani Tahir Ahmad , Yadav Miklesh Prasad
Published: February 2022

COVID-19 quickly spread all over the world and dramatically affected the financial markets in almost everycountry. Its spread created havoc in the market, and investors fearing risk suffereda significant amount of financialloss in a very short time. This article aims to analyze the impact of COVID-19 on stock markets in the top six affected countries based on the total number of cases confirmed. In addition, it also analyzes the stock market volatility caused by the virus and the abnormal returns generated by the markets during the pandemic. We employevent study methodology in different sub-periods to examine the most volatile event periods with the daily rise in the Covid cases and subsequent returns generated by the markets during these sub-periodsin relation to the daily rise in the case. The increase in volatility and the presence of significant abnormal returns among the sample indices show the impact of COVID-19 on stock markets. The result reveals that Brazilian stock indices show the highest decline among the selected countries, with a fall of more than 50% during the pandemic, while Mexican indices show the lowest fall of around 30% during the same period.
Does Adjusting for Social Desirability Reduce Ceiling Effects and Increase Variation of Patient-Reported Experience Measures?
Authors: Badejo Megan A. , Ramtin Sina , Rossano Ayane , Ring David , Koenig Karl , Crijns Tom J
Published: February 2022

Social desirability bias (a tendency to underreport undesirable attitudes and behaviors) may account, in part, for the notable ceiling effects and limited variability of patient-reported experience measures (PREMs) such as satisfaction, communication effectiveness, and perceived empathy. Given that there is always room for improvement for both clinicians and the care environment, ceiling effects can hinder improvement efforts. This study tested whether weighting of satisfaction scales according to the extent of social desirability can create a more normal distribution of scores and less ceiling effect. In a cross-sectional study 118 English-speaking adults seeking musculoskeletal specialty care completed 2 measures of satisfaction with care (one iterative scale and one 11-point ordinal scale), a measure of social desirability, and basic demographics. Normality of satisfaction scores was assessed using Shapiro-Wilk tests. After weighting for social desirability, scores on the iterative satisfaction scale had a more normal distribution while scores on the 11-point ordinal satisfaction scale did not. The ceiling effects in satisfaction decreased from 47% (n = 56) to 2.5% (n = 3) for the iterative scale, and from 81% (n = 95) to 2.5% (n = 3) for the ordinal scale. There were no differences in mean satisfaction when the social desirability was measured prior to completion of the satisfaction surveys compared to after. The observation that adjustment for levels of social desirability bias can reduce ceiling effects suggests that accounting for personal factors could help us develop PREMs with greater variability in scores, which may prove useful for quality improvement efforts.
‘No Means No’: People’s Protest Against Hydroelectric Development in Kinnaur, Himachal Pradesh, India
Authors: Negi Dandub Palzor , Abdul Azeez EP
Published: February 2022

Development projects, primarily hydroelectric power projects, are considered viable renewable energy sources and contribute to sustaining the economy at large. However, it has been contested over excessive exploitation and appropriation of environment and ecology. Such development models have been challenged worldwide for threatening human survival degrading ecology and the environment. Hydroelectric development in the geographically fragile regions of the Himalayas is on the rise owing to the great potential of hydro energy in the region. This article examines the public protest against the hydroelectric project, the Jangi-Thopan-Powari Hydro Electric project, in the Kinnaur district of Himachal Pradesh.
The Role of Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation
Authors: Page Martin J. , Kell Douglas B. , Pretorius Etheresia
Published: February 2022

Lipopolysaccharide (LPS) is the main structural component of the outer membrane of most Gram-negative bacteria and has diverse immunostimulatory and procoagulant effects. Even though LPS is well described for its role in the pathology of sepsis, considerable evidence demonstrates that LPS-induced signalling and immune dysregulation are also relevant in the pathophysiology of many diseases, characteristically where endotoxaemia is less severe. These diseases are typically chronic and progressive in nature and span broad classifications, including neurodegenerative, metabolic, and cardiovascular diseases. This Review reappraises the mechanisms of LPS-induced signalling and emphasises the crucial contribution of LPS to the pathology of multiple chronic diseases, beyond conventional sepsis. This perspective asserts that new ways of approaching chronic diseases by targeting LPS-driven pathways may be of therapeutic benefit in a wide range of chronic inflammatory conditions.
Ranibizumab port delivery system in neovascular age-related macular degeneration
Authors: Chandrasekaran Priya R. , Madanagopalan V.G.
Published: February 2022

Ranibizumab has proven its efficacy in various retinal diseases and particularly in neovascular age-related macular degeneration (nAMD). The number of injections and the frequent follow-up visits has been burdensome to patients particularly during the COVID era. Ranibizumab port delivery system (RPDS) seems to be a boon in prolonging the action of the drug without the need for frequent injections and follow-up visits. This review article highlights the dosage, adverse effects, and visual outcome associated with various trials of RPDS. For this article, we conducted a PubMed search and review of literature on nAMD, the incidence of AMD, anti-vascular endothelial growth factor (anti-VEGF) agents, RPDS, phase-1 trial of RPDS, phase-2 (LADDER trial) of RPDS, phase-3 (ARCHWAY trial) of RPDS, PORTAL trial of RPDS, results of phase-1 trial of RPDS, results of phase-2 (LADDER) trial of RPDS, and results of phase-3 (ARCHWAY) trial of RPDS.
Donor-derived multiple leukemia antigen–specific T-cell therapy to prevent relapse after transplant in patients with ALL
Authors: Naik Swati , Vasileiou Spyridoula , Tzannou Ifigeneia , Kuvalekar Manik , Watanabe Ayumi , Robertson Catherine , Lapteva Natalia , Tao Wang , Wu Mengfen , Grilley Bambi , Carrum George , Kamble Rammurti T. , Hill LaQuisa , Krance Robert A. , Martinez Caridad , Tewari Priti , Omer Bilal , Gottschalk Stephen , Heslop Helen E. , Brenner Malcom K. , Rooney Cliona M. , Vera Juan F. , Leen Ann M. , Lulla Premal D.
Published: February 2022

Hematopoietic stem cell transplant (HSCT) is a curative option for patients with high-risk acute lymphoblastic leukemia (ALL), but relapse remains a major cause of treatment failure. To prevent disease relapse, we prepared and infused donor-derived multiple leukemia antigen–specific T cells (mLSTs) targeting PRAME, WT1, and survivin, which are leukemia-associated antigens frequently expressed in B- and T-ALL. Our goal was to maximize the graft-versus-leukemia effect while minimizing the risk of graft-versus-host disease (GVHD). We administered mLSTs (dose range, 0.5 × 107 to 2 × 107 cells per square meter) to 11 patients with ALL (8 pediatric, 3 adult), and observed no dose-limiting toxicity, acute GVHD or cytokine release syndrome. Six of 8 evaluable patients remained in long-term complete remission (median: 46.5 months; range, 9-51). In these individuals we detected an increased frequency of tumor-reactive T cells shortly after infusion, with activity against both targeted and nontargeted, known tumor-associated antigens, indicative of in vivo antigen spreading. By contrast, this in vivo amplification was absent in the 2 patients who experienced relapse. In summary, infusion of donor-derived mLSTs after allogeneic HSCT is feasible and safe and may contribute to disease control, as evidenced by in vivo tumor-directed T-cell expansion. Thus, this approach represents a promising strategy for preventing relapse in patients with ALL.
G6b-B regulates an essential step in megakaryocyte maturation
Authors: Becker Isabelle C. , Nagy Zoltan , Manukjan Georgi , Haffner-Luntzer Melanie , Englert Maximilian , Heib Tobias , Vögtle Timo , Gross Carina , Bharti Richa , Dietrich Sascha , Mott Kristina , Heck Johannes , Stegmaier Sebastian , Baranowsky Anke , Schinke Thorsten , Schlegel Nicolas , Heckel Tobias , Stegner David , Pleines Irina , Ignatius Anita , Schulze Harald , Nieswandt Bernhard
Published: February 2022

G6b-B is a megakaryocyte lineage-specific immunoreceptor tyrosine-based inhibition motif–containing receptor, essential for platelet homeostasis. Mice with a genomic deletion of the entire Mpig6b locus develop severe macrothrombocytopenia and myelofibrosis, which is reflected in humans with null mutations in MPIG6B. The current model proposes that megakaryocytes lacking G6b-B develop normally, whereas proplatelet release is hampered, but the underlying molecular mechanism remains unclear. We report on a spontaneous recessive single nucleotide mutation in C57BL/6 mice, localized within the intronic region of the Mpig6b locus that abolishes G6b-B expression and reproduces macrothrombocytopenia, myelofibrosis, and osteosclerosis. As the mutation is based on a single-nucleotide exchange, Mpig6bmut mice represent an ideal model to study the role of G6b-B. Megakaryocytes from these mice were smaller, displayed a less-developed demarcation membrane system, and had a reduced expression of receptors. RNA sequencing revealed a striking global reduction in the level of megakaryocyte-specific transcripts, in conjunction with decreased protein levels of the transcription factor GATA-1 and impaired thrombopoietin signaling. The reduced number of mature MKs in the bone marrow was corroborated on a newly developed Mpig6b-null mouse strain. Our findings highlight an unexpected essential role of G6b-B in the early differentiation within the megakaryocytic lineage.
Fludarabine exposure predicts outcome after CD19 CAR T-cell therapy in children and young adults with acute leukemia
Authors: Dekker Linde , Calkoen Friso G. , Jiang Yilin , Blok Hilly , Veldkamp Saskia R. , De Koning Coco , Spoon Maike , Admiraal Rick , Hoogerbrugge Peter , Vormoor Britta , Vormoor H. Josef , Visscher Henk , Bierings Marc , Van Der Vlugt Marieke , Van Tinteren Harm , Nijstad A. Laura , Huitema Alwin D. R. , Van Der Elst Kim C. M. , Pieters Rob , Lindemans Caroline A. , Nierkens Stefan
Published: February 2022

The addition of fludarabine to cyclophosphamide as a lymphodepleting regimen prior to CD19 chimeric antigen receptor (CAR) T-cell therapy significantly improved outcomes in patients with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL). Fludarabine exposure, previously shown to be highly variable when dosing is based on body surface area (BSA), is a predictor for survival in allogeneic hematopoietic cell transplantation (allo-HCT). Hence, we hypothesized that an optimal exposure of fludarabine might be of clinical importance in CD19 CAR T-cell treatment. We examined the effect of cumulative fludarabine exposure during lymphodepletion, defined as concentration-time curve (AUC), on clinical outcome and lymphocyte kinetics. A retrospective analysis was conducted with data from 26 patients receiving tisagenlecleucel for r/r B-ALL. Exposure of fludarabine was shown to be a predictor for leukemia-free survival (LFS), B-cell aplasia, and CD19-positive relapse following CAR T-cell infusion. Minimal event probability was observed at a cumulative fludarabine AUCT0−∞ ≥14 mg*h/L, and underexposure was defined as an AUCT0−∞ <14 mg*h/L. In the underexposed group, the median LFS was 1.8 months, and the occurrence of CD19-positive relapse within 1 year was 100%, which was higher compared with the group with an AUCT0−∞ ≥14 mg*h/L (12.9 months; P < .001; and 27.4%; P = .0001, respectively). Furthermore, the duration of B-cell aplasia within 6 months was shorter in the underexposed group (77.3% vs 37.3%; P = .009). These results suggest that optimizing fludarabine exposure may have a relevant impact on LFS following CAR T-cell therapy, which needs to be validated in a prospective clinical trial.
Genomewide transcriptional response of Escherichia coli O157:H7 to norepinephrine
Authors: Sharma Vijay K. , Akavaram Suryatej , Bayles Darrell O.
Published: February 2022

Background

Chemical signaling between a mammalian host and intestinal microbes is health and maintenance of ‘healthy’ intestinal microbiota. Escherichia coli O157:H7 can hijack host- and microbiota-produced chemical signals for survival in a harsh and nutritionally competitive gastrointestinal environment and for intestinal colonization. Norepinephrine (NE) produced by sympathetic neurons of the enteric nervous system has been shown in vitro to induce expression of genes controlling E. coli O157:H7 swimming motility, acid resistance, and adherence to epithelial cells. A previous study used a microarray approach to identify differentially expressed genes in E. coli O157:H7 strain EDL933 in response to NE. To elucidate a comprehensive transcriptional response to NE, we performed RNA-Seq on rRNA-depleted RNA of E. coli O157:H7 strain NADC 6564, an isolate of a foodborne E. coli O157:H7 strain 86–24. The reads generated by RNA-Seq were mapped to NADC 6564 genome using HiSat2. The mapped reads were quantified by htseq-count against the genome of strain NADC 6564. The differentially expressed genes were identified by analyzing quantified reads by DESeq2.

Results

Of the 585 differentially expressed genes (≥ 2.0-fold; p < 0.05), many encoded pathways promoting ability of E. coli O157:H7 strain NADC 6564 to colonize intestines of carrier animals and to produce disease in an incidental human host through increased adherence to epithelial cells and production of Shiga toxins. In addition, NE exposure also induced the expression of genes encoding pathways conferring prolonged survival at extreme acidity, controlling influx/efflux of specific nutrients/metabolites, and modulating tolerance to various stressors. A correlation was also observed between the EvgS/EvgA signal transduction system and the ability of bacterial cells to survive exposure to high acidity for several hours. Many genes involved in nitrogen, sulfur, and amino acid uptake were upregulated while genes linked to iron (Fe3+) acquisition and transport were downregulated.

Conclusion

The availability of physiological levels of NE in gastrointestinal tract could serve as an important cue for E. coli O157:H7 to engineer its virulence, stress, and metabolic pathways for colonization in reservoir animals, such as cattle, causing illness in humans, and surviving outside of a host.
Evaluation of methods to detect circular RNAs from single-end RNA-sequencing data
Authors: Nguyen Manh Hung , Nguyen Ha-Nam , Vu Trung Nghia
Published: February 2022

Background

Circular RNA (circRNA), a class of RNA molecule with a loop structure, has recently attracted researchers due to its diverse biological functions and potential biomarkers of human diseases. Most of the current circRNA detection methods from RNA-sequencing (RNA-Seq) data utilize the mapping information of paired-end (PE) reads to eliminate false positives. However, much of the practical RNA-Seq data such as cross-linking immunoprecipitation sequencing (CLIP-Seq) data usually contain single-end (SE) reads. It is not clear how well these tools perform on SE RNA-Seq data.

Results

In this study, we present a systematic evaluation of six advanced RNA-based methods and two CLIP-Seq based methods for detecting circRNAs from SE RNA-Seq data. The performances of the methods are rigorously assessed based on precision, sensitivity, F1 score, and true discovery rate. We investigate the impacts of read length, false positive ratio, sequencing depth and PE mapping information on the performances of the methods using simulated SE RNA-Seq simulated datasets. The real datasets used in this study consist of four experimental RNA-Seq datasets with ≥100bp read length and 124 CLIP-Seq samples from 45 studies that contain mostly short-read (≤50bp) RNA-Seq data. The simulation study shows that the sensitivities of most of the methods can be improved by increasing either read length or sequencing depth, and that the levels of false positive rates significantly affect the precision of all methods. Furthermore, the PE mapping information can improve the method’s precision but can not always guarantee the increase of F1 score. Overall, no method is dominant for all SE RNA-Seq data. The RNA-based methods perform better for the long-read datasets but are worse for the short-read datasets. In contrast, the CLIP-Seq based methods outperform the RNA-Seq based methods for all the short-read samples. Combining the results of these methods can significantly improve precision in the CLIP-Seq data.

Conclusions

The results provide a systematic evaluation of circRNA detection methods on SE RNA-Seq data that would facilitate researchers’ strategies in circRNA analysis.
Airway management in a Helicopter Emergency Medical Service (HEMS): a retrospective observational study of 365 out-of-hospital intubations
Authors: Pietsch Urs , Müllner Raphael , Theiler Lorenz , Wenzel Volker , Meuli Lorenz , Knapp Jürgen , Sollid Stephen J. M. , Albrecht Roland
Published: February 2022

Background

Airway management is a key skill in any helicopter emergency medical service (HEMS). Intubation is successful less often than in the hospital, and alternative forms of airway management are more often needed.

Methods

Retrospective observational cohort study in an anaesthesiologist-staffed HEMS in Switzerland. Patient charts were analysed for all calls to the scene (n = 9,035) taking place between June 2016 and May 2017 (12 months). The primary outcome parameter was intubation success rate. Secondary parameters included the number of alternative techniques that eventually secured the airway, and comparison of patients with and without difficulties in airway management.

Results

A total of 365 patients receiving invasive ventilatory support were identified. Difficulties in airway management occurred in 26 patients (7.1%). Severe traumatic brain injury was the most common indication for out-of-hospital Intubation (n = 130, 36%). Airway management was performed by 129 different Rega physicians and 47 different Rega paramedics. Paramedics were involved in out-of-hospital airway manoeuvres significantly more often than physicians: median 7 (IQR 4 to 9) versus 2 (IQR 1 to 4),p < 0.001.

Conclusion

Despite high overall success rates for endotracheal intubation in the physician-staffed service, individual physicians get only limited real-life experience with advanced airway management in the field. This highlights the importance of solid basic competence in a discipline such as anaesthesiology.
Long-term clinical outcomes of patients with nonsignificant transplanted renal artery stenosis
Authors: Barteczko Manoela Linhares Machado , Orellana Henry Campos , Santos Gustavo Rocha Feitosa , Galhardo Attílio , Kanhouche Gabriel , Faccinetto Ana Carolina Buso , Júnior Hélio Tedesco , Pestana José Osmar Medina , de Paola Ângelo Amato Vincenzo , Barbosa Adriano Henrique Pereira
Published: February 2022

Background

Transplant renal artery stenosis (TRAS) is the main vascular complication of kidney transplantation. For research and treatment purposes, several authors consider critical renal artery stenosis to be greater than 50%, and percutaneous intervention is indicated in this scenario. However, there are no reports in the current literature on the evolution of patients with less than 50% stenosis.

Method

This retrospective study included data from all patients who underwent kidney transplantation and were suspected of having TRAS after transplantation with stenosis under 50% independent of age and were referred for angiography at a single centre between January 2007 and December 2014.

Results

During this period, 6,829 kidney transplants were performed at Hospital do Rim, 313 of whom had a clinical suspicion of TRAS, and 54 of whom presented no significant stenosis. The average age was 35.93 years old, the predominant sex was male, and most individuals (94.4%) underwent dialysis before transplantation. In most cases in this group, transplants occurred from a deceased donor (66.7%). The time between transplantation and angiography was less than one year in 79.6% of patients, and all presented nonsignificant TRAS. Creatinine levels, systolic blood pressure, diastolic blood pressure and glomerular filtration rate improved over the long term. The outcomes found were death and allograft loss.

Conclusion

Age, sex and ethnic group of patients were factors that did not interfere with the frequency of renal artery stenosis. The outcomes showed that in the long term, most patients evolve well and have improved quality of life and kidney function, although there are cases of death and kidney loss.
Massive digital gene expression analysis reveals different predictive profiles for immune checkpoint inhibitor therapy between adenocarcinoma and squamous cell carcinoma of advanced lung cancer
Authors: Kaneda Toshihiko , Kurata Takayasu , Yoshida Tomoko , Kibata Kayoko , Yoshioka Hiroshige , Yanagimoto Hiroaki , Takeda Kazuhiko , Yoshida Takao , Tsuta Koji
Published: February 2022

Background

Immune checkpoint inhibitors prolong the survival of non-small cell lung cancer (NSCLC) patients. Although it has been acknowledged that there is some correlation between the efficacy of anti-programmed cell death-1 (PD-1) antibody therapy and immunohistochemical analysis, this technique is not yet considered foolproof for predicting a favorable outcome of PD-1 antibody therapy. We aimed to predict the efficacy of nivolumab based on a comprehensive analysis of RNA expression at the gene level in advanced NSCLC.

Methods

This was a retrospective study on patients with NSCLC who were administered nivolumab at the Kansai Medical University Hospital. To identify genes associated with response to anti-PD-1 antibodies, we grouped patients into responders (complete and partial response) and non-responders (stable and progressive disease) to nivolumab therapy. Significant genes were then identified for these groups using Welch’s t-test.

Results

Among 42 analyzed cases (20 adenocarcinomas and 22 squamous cell carcinomas), enhanced expression ofMAGE-A4,BBC3,andOTOAgenes was observed in responders with adenocarcinoma, and enhanced expression ofDAB2,HLA-DPB,1andCDH2genes was observed in responders with squamous cell carcinoma.

Conclusions

This study predicted the efficacy of nivolumab based on a comprehensive analysis of mRNA expression at the gene level in advanced NSCLC. We also revealed different gene expression patterns as predictors of the effectiveness of anti PD-1 antibody therapy in adenocarcinoma and squamous cell carcinoma.
Malignant glaucoma following gonioscopy-assisted transluminal trabeculotomy: a case report
Authors: Bolletta Elena , Iannetta Danilo , Moramarco Antonio , Fontana Luigi
Published: February 2022

Background

To report a case of malignant glaucoma that developed after gonioscopy-assisted transluminal trabeculotomy (GATT).

Case presentation

An 85-year-old male pseudophakic patient affected by pseudoexfoliative glaucoma (PEXG), unresponsive to medical glaucoma treatment, underwent uneventful GATT surgery. On the first day after surgery, the eye showed a shallow central and peripheral anterior chamber (AC) with a raised intraocular pressure (IOP) measured at 55 mmHg. Optical coherence tomography and ultrasound biomicroscopy confirmed the diagnosis of malignant glaucoma.

Laser iridotomy, posterior capsulotomy and hyaloidotomy were performed, and the patient was treated with atropine sulphate 1%, maximum topical and systemic ocular hypotensive drugs with no improvement in the IOP. Subsequently, the patient underwent pars plana anterior vitrectomy, resulting in deepening of the AC with opening of the iridocorneal angle and decrease of the IOP. No further postoperative complications were recorded, and the IOP remained controlled 12 months after surgery without antiglaucoma medications.

Conclusions

Despite the minimally invasive profile of GATT, malignant glaucoma may develop after this procedure. Early recognition and prompt treatment are mandatory for preventing permanent visual loss.
Trends in hospitalization for paediatric flatfoot: an Italian nationwide study from 2001 to 2016
Authors: Longo Umile Giuseppe , Papalia Rocco , De Salvatore Sergio , Ruzzini Laura , Candela Vincenzo , Piergentili Ilaria , Oggiano Leonardo , Costici Pier Francesco , Denaro Vincenzo
Published: February 2022

Background

Flatfoot is a common condition in young patients, but usually resolves by adolescence. This study aimed to estimate annual trend hospitalizations for flatfoot in Italian paediatric population from 2001 to 2016.

Methods

Data of this study were collected from the National Hospital Discharge Reports (SDO) reported at the Italian Ministry of Health regarding the years of this paper (2001–2016). The yearly number of hospital admission for flatfoot, the percentage of males and females, the average age, the average days of hospitalization, primary diagnoses and primary procedures in the whole Italian population were calculated using descriptive statistical analyses.

Results

109,300 hospitalizations for flatfoot of young patients were performed during this period. 59.3% of patients were male and 40.7% female of the 10–14 years-old age class. The average days of hospitalization stay were 1.73 ± 1.27 days. The data highlights that the burden of flatfoot surgery is growing and affecting the healthcare system. The mean rate of hospital admissions in Italy for flatfoot in the young population was 82.14 for 100,000 inhabitants of the same age class.

Conclusions

The data highlights that the cases of flatfoot surgery increased from 2001 to 2016. The most common treatment was the “Internal Fixation Of Bone Without Fracture Reduction, Tarsals And Metatarsals followed by Subtalar Fusion and Arthroereisis. Further prospective studies on this topic may be conducted to improve the evidence of the results.
Prevention and control of mosquito-borne arboviral diseases: lessons learned from a school-based intervention in Brazil (Zikamob)
Authors: Santos Silvana , Smania-Marques Roberta , Albino Victor Alves , Fernandes Izabelly Dutra , Mangueira Francisco Fernandes Abel , Altafim Ruy Alberto Pisani , Olinda Ricardo , Smith Matt , Traxler John
Published: February 2022

Background

Since the 1980s, when dengue was reintroduced in Brazil, outbreaks and epidemics caused by different arbovirus strains transmitted by vector mosquitoes such as Aedes aegypti have been an annual occurrence. The aim of this study was to evaluate the behavioural change of high school students and teachers who participated in an educational intervention for the prevention and vector control of arboviral diseases.

Methods

In this school-based intervention, a self-reported questionnaire was used in a pre-post intervention methodology to assess environmental risk factors, sociodemographic variables and to measure attitudes and behaviours. In all, 883 high school students and teachers from the city of Campina Grande, in the state of Paraíba, northeastern Brazil, participated. The e-health intervention consisted of a competition between schools to comply with preventive actions via content production for social networks, and the monitoring was performed over a period of three months through the ZikaMob software developed by the researchers.

Results

Out of the 883 survey participants, 690 were students ranging in age from 14 to 41 years, with an average of 17 ± 2 years; and 193 were teachers from 22 to 64 years old, averaging 38 ± 9 years. The analysis of the data shows that significant differences in most of the target behaviours were apparent after the intervention, with an increase of about 10% in the performance of inspection actions; a 7% greater separation of recyclables and a 40% increase in the screening of windows among students. Students showed lower fear of, and a lower self-perception of the risk of, acquiring arboviruses than teachers on average.

Conclusions

ZikaMob is an innovative strategy with the potential to be replicated in any location that has an internet network and can involve an unlimited number of participants.
Opportunities to engage health system leaders in whole systems approaches to physical activity in England
Authors: Bird E. L. , Evans D. , Gray S. , Atherton E. , Blackshaw J. , Brannan M. , Corrigan N. , Weiner D.
Published: February 2022

Background

Physical activity plays an important role in maintaining good health and wellbeing, non-communicable disease prevention and can improve healthcare outcomes. Some progress is being made on incorporating physical activity into routine care, but less on engaging health system leaders in the ‘whole systems’ approaches which are increasingly recognised as important for addressing complex public health challenges such as physical inactivity. This commentary builds upon the findings of a recent study and aims to identify opportunities for engaging National Health Service (NHS) systems leaders in whole systems approaches to physical activity.

Opportunities for action in England

Pockets of good practice exist from which lessons can be learned, but there are systemic issues that discourage and create barriers, and a need for meaningful engagement, leadership and action at national, regional and local levels. National and regional actors like Sport England, NHS England, health professional bodies, Active Partnerships, the Local Government Association and the Office for Health Improvement and Disparities can encourage and support government and the NHS to change policy drivers, culture and practices. Emerging opportunities include the 2021 White Paper Integration and Innovation, development of local integrated care systems, leadership from health charities and investment in non-clinical interventions (‘social prescribing’). At local level, public health and physical activity specialists and other organisations have a key role as champions and facilitators of local whole systems approaches and engagement of local NHS leaderships. Finally, although whole systems action is about collaborative leadership, individual champions of physical activity can make a difference in influencing NHS leaders at every level towards whole systems working.
Missed opportunities for family planning counselling among postpartum women in eleven counties in Kenya
Authors: Thiongo Mary N. , Gichangi Peter B. , Waithaka Michael , Tsui Amy , Zimmerman Linnea A. , Radloff Scott , Temmerman Marleen , Ahmed Saifuddin
Published: February 2022

Background

Mothers may access medical facilities for their babies and miss opportunities to access family planning (FP) services. This study was undertaken to describe missed opportunities for FP among women within the extended (0–11 months) postpartum period from counties participating in Performance Monitoring and Accountability 2020 (PMA2020) surveys.

Design and setting

This study analysed cross-sectional household survey data from 11 counties in Kenya between 2014 and 2018. PMA2020 uses questions extracted from the Demographic and Health survey (DHS) and DHS definitions were used. Multivariable logistic regression was used for inferential statistics with p-value of < 0.05 considered to be significant.

Participants

Women aged 15-49 years from the households visited.

Primary outcome measure

Missed opportunity for family planning/contraceptives (FP/C) counselling.

Results

Of the 34,832 women aged 15-49 years interviewed, 10.9% (3803) and 10.8% (3746) were in the period 0–11 months and 12–23 months postpartum respectively, of whom, 38.8 and 39.6% respectively had their previous pregnancy unintended. Overall, 50.4% of women 0-23 months postpartum had missed opportunities for FP/C counselling. Among women who had contact with health care at the facility, 39.2% of women 0-11 months and 44.7% of women 12-23 months had missed opportunities for FP/C counselling. Less than half of the women 0-11 months postpartum (46.5%) and 64.5% of women 12 – 23 months postpartum were using highly efficacious methods. About 27 and 18% of the women 0-11 months and 12 – 23 months postpartum respectively had unmet need for FP/C. Multivariable analysis showed that being low parity and being from the low wealth quintile significantly increased the odds of missed opportunities for FP/C counselling among women in the extended postpartum period, p < 0.05.

Conclusions

A large proportion of women have missed opportunities for FP/C counselling within 2 years postpartum. Programs should address these missed opportunities.
Cytopathological analysis of bronchoalveolar lavage fluid in patients with and without HIV infection
Authors: Chen Xiang-mei , Sun Lei , Yang Kun , Chen Jia-min , Zhang Liang , Han Xiao-yi , Zhou Xingang , Ma Zhi-yuan , Li Man , Zhao Hong-xin , Qi Li-ming , Wang Peng
Published: February 2022

Background

Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) infection can lead to a broad spectrum of lung diseases, including infectious diseases and tumors. Recently, with the wide application of bronchoscopes and cytopathology of bronchoalveolar lavage fluid (BALF), the diagnostic efficiency of lung diseases has improved. The present study focuses on analyzing the cytopathologic characteristics of BALF in the diagnosis of HIV/AIDS-related lung disease and comparing the lung disease spectrum between HIV and HIV-uninfected patients.

Methods

BALF specimens were collected from 2211 patients. Using ThinPrep liquid-based technology, the cytologic smears were prepared by staining with Hematoxylin and Eosin (HE), Gomori's methenamine silver (GMS), and Periodic Acid Schiff (PAS), acid-fast and immunocytochemical (ICC) staining. Real-time PCR was used to detect cytomegalovirus (CMV) and Mycobacterium tuberculosis (M. tuberculosis) in the remaining BALF. PCR-reverse dot hybridization was used for mycobacterial species identification.

Results

From the 2211 BALF specimens, 1768 (79.96%) were specimens from HIV-infected patients, and 443 (20.04%) were speciments from HIV-uninfected patients. The HIV-infected patients with a median age of 38.5 ± 11.3 years were markedly younger than the HIV-uninfected patients (52.9 ± 14.9 years) (p < 0.01). We found that 1635 (92.5%) HIV-infected patients were males, showing a prominently higher proportion than those without HIV infection (71.1%) (p < 0.01). Meanwhile, 1045 specific lesions were found in 1768 HIV-infected patients (59.1%), including 1034 cases of infectious diseases and 11 neoplastic lesions, also exhibiting a distinctly higher proportion compared to the HIV-uninfected patients (12.2%) (p < 0.001). For the HIV-infected group, a distinctly higher proportion of single infection lesions (724/1768, 41%) was noted than the HIV-uninfected group (14/443, 3.2%) (p < 0.001). Among single infection lesions, the most common was Cytomegalovirus(CMV) infection (20.9%) for the HIV-infected group, followed by Pneumocystis jiroveci(PJ) (13.0%), Fungal (3.5%), and Mycobacterial infections (3.4%), of which M. tuberculosis infection accounted for 3.1%. Double infections (300/1768, 17.0%) and Triple infections (10/1768, 0.6%) were found only among the patients with HIV. The malignancies among HIV-infected patients included adenocarcinomas (0.22%), small cell carcinomas (0.2%), squamous cell carcinomas (0.1%), and diffuse large B-cell lymphoma (0.1%). HIV-infected patients exhibited a significantly lower incidence of neoplastic lesions (0.6% vs. 9.0%) than the HIV-uninfected patients (p < 0.001).

Conclusions

There was a significant difference in the spectrum of lung diseases between HIV-infected and non-infected patients diagnosed by BALF cytopathology.
Evaluation of lateral pterygoid muscle in patients with temporomandibular joint anterior disk displacement using T1-weighted Dixon sequence: a retrospective study
Authors: Wang Shuo , Chen Yu , She Dejun , Xing Zhen , Guo Wei , Wang Feng , Huang Hongjie , Huang Nan , Cao Dairong
Published: February 2022

Background

Pathological alterations of lateral pterygoid muscle (LPM) are implicated in temporomandibular joint anterior disk displacement (ADD). However, quantification of the fatty infiltration of LPM and its correlation with ADD have rarely been reported. The aim of this study was to evaluate the fatty infiltration, morphological features and texture features of LPM in patients with ADD using T1-weighted Dixon sequence.

Methods

This retrospective study included patients who underwent temporomandibular joint MRI with T1-weighted Dixon sequence between December 2018 and August 2020. The temporomandibular joints of the included patients were divided into three groups according to the position of disk: Normal position disk (NP) group, Anterior disk displacement with reduction (ADDWR) group and Anterior disk displacement without reduction (ADDWOR) group. Fat fraction, morphological features (Length; Width; Thickness), and texture features (Angular second moment; Contrast; Correlation; Inverse different moment; Entropy) extracted from in-phase image of LPM were evaluated. One-way ANOVA, Welch’s ANOVA, Kruskal–Wallis test, Spearman and Pearson correlation analysis were performed. Intra-class correlation coefficient was used to evaluate the reproducibility.

Results

A total of 53 patients with 106 temporomandibular joints were evaluated. Anterior disk displacement without reduction group showed higher fat fraction than normal position disk group (P = 0.024). Length of LPM was negatively correlated with fat fraction (r = -0.22, P = 0.026). Angular second moment (ρ = -0.32, P < 0.001), correlation (ρ = -0.28, P = 0.003) and inverse different moment (ρ = -0.27, P = 0.005) were negatively correlated with fat fraction, while positive correlation was found between entropy and fat fraction (ρ = 0.31, P = 0.001). The intra-class correlation coefficients for all values were ranged from 0.80 to 0.97.

Conclusions

Patients with ADDWOR present more fatty infiltration in the LPM compared to NP or ADDWR patients. Fatty infiltration of LPM was associated with more atrophic and higher intramuscular heterogeneity in patients with ADD. Fat fraction of LPM quantitatively and noninvasively evaluated by Dixon sequence may has utility as an imaging-based marker of the structural severity of ADD disease process, which could be clinical helpful for the early diagnose of ADD and predication of disease progression.
Preoperative management and postoperative complications associated with transoral decompression for the upper cervical spine
Authors: Li Wenqiang , Wang Bingjin , Feng Xiaobo , Hua Wenbin , Yang Cao
Published: February 2022

Purpose

This review aimed to describe the preoperative management and postoperative complications associated with transoral decompression of the upper cervical spine, and to clarify the risk factors, related issues and complication management.

Methods

Studies on transoral decompression for the upper cervical spine were reviewed systematically. The preoperative management and postoperative complications associated with transoral decompression for upper cervical deformities were analyzed.

Results

Evidence suggests that preoperative management in patients undergoing transoral decompression for the upper cervical spine is closely related to the occurrence of postoperative complications. Hence, preoperative surgical planning, preoperative preparation, and oral nursing care should be seriously considered in these patients. Moreover, while being established as an effective and safe method, transoral decompression is associated with several postoperative complications, which could be prevented by elaborate preoperative management, improved surgical skills, and appropriate precautionary measures.

Conclusions

The effectiveness and safety of transoral decompression has been improved by the constant development of operative techniques and advanced auxiliary diagnostic and therapeutic methods, with the understanding of the anatomical structure of the craniocervical joint. Therefore, the incidence rates of postoperative complications have decreased. The application of individualized anterior implants and less-invasive endoscopic endonasal approach has improved the effectiveness of transoral decompression and reduced the associated complications.
Evaluation of Doc’EDS: a French semantic search tool to query health documents from a clinical data warehouse
Authors: Pressat-Laffouilhère Thibaut , Balayé Pierre , Dahamna Badisse , Lelong Romain , Billey Kévin , Darmoni Stéfan J. , Grosjean Julien
Published: February 2022

Background

Unstructured data from electronic health records represent a wealth of information. Doc’EDS is a pre-screening tool based on textual and semantic analysis. The Doc’EDS system provides a graphic user interface to search documents in French. The aim of this study was to present the Doc’EDS tool and to provide a formal evaluation of its semantic features.

Methods

Doc’EDS is a search tool built on top of the clinical data warehouse developed at Rouen University Hospital. This tool is a multilevel search engine combining structured and unstructured data. It also provides basic analytical features and semantic utilities. A formal evaluation was conducted to measure the impact of Natural Language Processing algorithms.

Results

Approximately 18.1 million narrative documents are stored in Doc’EDS. The formal evaluation was conducted in 5000 clinical concepts that were manually collected. The F-measures of negative concepts and hypothetical concepts were respectively 0.89 and 0.57.

Conclusion

In this formal evaluation, we have shown that Doc’EDS is able to deal with language subtleties to enhance an advanced full text search in French health documents. The Doc’EDS tool is currently used on a daily basis to help researchers to identify patient cohorts thanks to unstructured data.
Telescreening satisfaction: disparities between individuals with diabetic retinopathy and community health center staff
Authors: Zhu Xiaofeng , Xu Yi , Lu Lina , Zou Haidong
Published: February 2022

Background

The success of telescreening and the management of diabetic retinopathy (DR) in communities depends on stakeholder satisfaction, including both individuals with diabetes and community health center (CHC) staff. In this study, we investigated the satisfaction of both individuals with vision-threatening DR (VTDR) and CHC staff within the Shanghai Eye Disease Study (SEDS) comprehensive system for managing diabetic eye diseases at the primary care level.

Methods

The cross-sectional survey of patients receiving the service included 3,817 respondents with VTDR and focused on their satisfaction with the SEDS system, including the telescreening process, speed of feedback, interpretation of results, increased awareness of related diseases, and eye care services. The survey of the providers included 234 CHC staff respondents and focused on their satisfaction and the main barriers encountered during the implementation of the system. Sociodemographic characteristics and perceived barriers related to satisfaction were identified by conducting univariate and multivariate logistic regression analyses.

Results

The overall satisfaction of service recipients was 96.0%, and 75.8% of them were willing to undergo future telescreening for DR. The convenience of telescreening, organization of telescreening, and improvement in related disease awareness significantly correlated with satisfaction. Only 48.3% of the providers were satisfied with the SEDS system. The most frequently mentioned barriers to the development of the system were the inadequate levels of staffing (particularly technical staff), insufficient funding, and incomplete information transmission systems.

Conclusions

Disparities between high patient satisfaction and low provider satisfaction with the SEDS system were mainly related to the current weak level of ophthalmic expertise in the CHCs and the low awareness of screening for diabetic eye diseases among both patients and providers.