bluuebunny/crossref_metadata_2025 huggingface dataset:
Gestión financiera para mejorar la rentabilidad de las MYPES comerciantes del mercado La Hermelinda, Trujillo
Authors: Mendiburu Rojas Jaime Alfonso , Ventura de Esquen Albertina Marina , Ramírez Cruzado Julissa Katia , Mendiburu Rojas Augusto Franklin
Published: April 2024

En la actualidad, la función financiera ha adquirido una importancia significativa en las micro y pequeñas empresas del Perú. La amplia gama de oportunidades de inversión y las diversas fuentes de financiamiento disponibles para estas empresas resaltan la necesidad de un conocimiento exhaustivo de las diferentes opciones, con el objetivo de tomar decisiones óptimas. Por ello, el propósito de esta investigación es destacar la relevancia de la gestión financiera para los empresarios MYPE (micro y pequeñas empresas). El objetivo es dar a conocer a estos comerciantes que una eficiente gestión financiera les ayudará a administrar eficazmente las potenciales fuentes de riqueza en el proceso de fortalecimiento empresarial, mejorando así su rentabilidad. El estudio se enmarca en una investigación descriptiva, con un diseño no experimental. La población objeto de estudio son las microempresas del sector de abarrotes del mercado La Hermelinda, con un total de 230 empresas, de las cuales se seleccionó una muestra aleatoria de 40 microempresas. Los resultados principales de las encuestas realizadas indican que el 65% de las Mypes realizan su gestión financiera de forma empírica, principalmente debido a la falta de conocimiento de la utilización de un plan de gestión financiera. Además, la mayoría de las Mypes financian sus actividades con recursos propios o préstamos de prestamistas particulares, careciendo de formalidad en la obtención de créditos.
Ensayos literarios del siglo XXI: Segundo tomo
Authors:   Universidad del Azuay, Pérez-Agustí Calos
Published: April 2024

En el segundo tomo de 'Ensayos Literarios para el Siglo XXI', Carlos Pérez Agustí nos sumerge en un fascinante viaje a través de la intersección entre la literatura, el cine y la cultura contemporánea. Publicado por la Casa Editorial UDA, este libro reúne análisis profundos y comentarios perspicaces sobre obras literarias y cinematográficas, divididas en cinco secciones que abarcan diversos géneros y temáticas. Destacando la influencia de figuras como Charles Chaplin, Franz Kafka y Pablo Palacio, Pérez Agustí explora la conexión entre la comedia, la existencialidad y la crítica social en la creación artística. Desde la literatura poética de Eugenio Moreno Heredia hasta los ensayos de Sara Vanégas sobre la metapoesía, el autor nos guía a través de un vasto panorama cultural y humanista. Además, se dedica un espacio especial en homenaje a Eliécer Cárdenas, resaltando su impacto en la literatura contemporánea. Este compendio revela el compromiso de Pérez Agustí con el arte y la enseñanza, buscando despertar emociones y reflexiones en un mundo cada vez más distante y apresurado. Una obra que invita a cuestionar el propósito de la escritura y a reafirmar la importancia de humanizar nuestras interacciones en la era de la globalización y la soledad. 322 páginas ISBN: 978-9942-645-67-8 e-ISBN: 978-9942-645-68-5
Does Habits of Mind-Based Instruction Catalyze Literacy Development? The Case of Jordanian EFL Learners
Authors: Bataineh Ruba Fahmi , Ali Meena Saleh
Published: April 2024

This study examines the potential effect of habits of mind-based instruction on Jordanian EFL tenth-grade students’ literacy development. A quasi-experimental design was used, as two intact sections (n=35) were drawn from a pool of five tenth-grade sections from Hay Al -Arqoub Basic Mixed School, a public school in the North-West Badia Department of Education, Mafraq (Jordan). The two sections were randomly distributed into a control group (n=18) and an experimental group (n=17). A pre-/post- test was used to assess the participants’ performance before and after the implementation of an eight-week habits of mind-based instructional program. Descriptive statistics of both central tendency and dispersion (e.g., means, Standard deviations, variance) were used to analyze the date. The findings revealed that the participants of the experimental group outperformed those in the control group in both reading and writing. The findings stress the importance of a conducive, non-threatening learning environment in which learners feel ‘safe’ to ask questions, engage in literacy-related activities, and interact with peers to achieve common goals. With practice, habits of mind become behaviors for students and teachers to build on, value, and use to handle situations in and outside the classroom.
Do Monetary Aggregates Improve Inflation Forecasting in Switzerland?
Authors: Kelly Logan J. , Binner Jane M. , Tepper Jonathan A.
Published: April 2024

This study examines whether or not Swiss monetary aggregates enhance inflation forecasting in Switzerland during the out-of-sample period, December 2008 to November 2019. We use a state-of-the-art multi-recurrent neural network endowed with a sluggish state-based memory to approximate a non-linear auto-regressive moving average model. Conventional monetary aggregates have been shown to lose dynamic information, potentially explaining why many deem traditional measures of the money supply to have minimal economic relevance. Our findings suggest that when conventional monetary aggregates, Divisia money measures, and a short-term interest rate are combined, forecasts of Swiss inflation over the 12, 24 and 36-month forecasting horizons are significantly improved compared to a model that excludes a measure of the money supply.
Hariciye Nazırı Mehemmed Hasan Hacınski’nin Azerbaycan ve Osmanlı Devleti Arasındaki Diplomatik Münasebetlerdeki Rolü
Authors: Demirci Hikmet , Baykuş Rıdvan
Published: April 2024

Rusya’da 1905 meşrutiyet yönetimi ve 1917 yılında meydana gelen Bolşevik Devrimi, Kafkasya bölgesini de etkilemiştir. Bolşeviklerin iktidara gelmesinin ardından Petersburg Geçici Hükümeti'nden bağımsız Güney Kafkasya'da Azerbaycan Türkleri, Gürcüler ve Ermeniler tarafından Transkafkasya Komiserliği (ZAKAVKOM)’ kuruldu. Sonraki süreçte Transkafkasya Komiserliği yerine Seym adında meclis açılmıştır. Bu Seym, ilk dış temaslarını komşusu Osmanlı Devleti ile Trabzon Konferansı’nda gerçekleştirmiştir, ancak konferansın sonunda herhangi bir anlaşmaya varılmamıştır. Seym’in Osmanlı Devleti’ne karşı açtığı savaşta başarısız olması üzerine, Osmanlı Devleti’nin şartlarını kabul ederek Batum Konferansı yapılmıştır.
Makale, Azerbaycan Halk Cumhuriyeti kurulmadan önce 14 Mart 1917 tarihinde Trabzon ve 11 Mayıs – 4 Haziran 1918’de gerçekleşen Batum Konferansı’nda görevlendirilen Memmed Hasan Hacınski’nin Osmanlı Devleti ile diplomatik münasebetleri hakkındadır. Makalenin amacı, Hacınski’nin kısa özgeçmişi ele alınarak Osmanlı - Azerbaycan dostluk ilişkisine katkısı, Trabzon ve Batum Konferanslarındaki diplomatik çalışmalarını ortaya koymaktır. Bu doğrultuda Hacınski’nin Trabzon ve Batum Konferansındaki faaliyetleri ve Osmanlı Devleti ile Azerbaycan ilişkilerinde izlediği siyaset değerlendirilmiştir. Sonuç olarak Hacınski’nin Trabzon Konferansında Osmanlı temsilcisi Enver Paşa ile görüşmesi, Batum Konferansı’nda Halil ve Vehib Paşalar ile görüşmeleri dostluk antlaşmasına giden süreci olumlu yönde etkiledi. Bu dostluk ilişkilerinin sonucunda Osmanlı Devleti’nden alınan askeri yardım ile Bakü şehri Sovyet işgalinden kurtarıldı.
Scent & Sensibility
Authors:   , Schepens Emma Josephine Adriana
Published: April 2024

Our sense of smell is a powerful yet often overlooked sense, and plays a crucial role to various facets of our lives including overall well-being, social interactions, emotions and memory. The COVID-19 pandemic has thrust this sense into the spotlight due to the significant number of individuals experiencing smell loss. However, healthcare providers are faced with the challenge of addressing this issue effectively, lacking comprehensive guidance in managing patients with COVID-19-induced smell loss. This thesis aims to fill this gap by providing a thorough examination of the diagnosis, treatment, epidemiology, and clinical course of COVID-19-induced smell loss.

Chapter 2 delves into the diagnostic accuracy of the Sniffin' Sticks Test (SST-12) as a screening tool for olfactory disorders, but not yet validated for smell disorders caused by COVID-19. While the validated extended SST are effective, their lengthy nature limits their practicality in routine clinical settings. We evaluated the SST-12's potential as a shorter screening tool and found promising results, suggesting its utility in detecting smell loss induced by COVID-19, albeit with the need of careful interpretation by healthcare professionals.

Building upon the hypothesis of COVID-19-induced inflammation affecting the olfactory nerve, Chapter 3 & 4 outlines the COCOS trial, a rigorous investigation into the efficacy of prednisolone in treating COVID-19-induced smell loss. Despite earlier promising indications, our randomized, double blinded, placebo controlled trial revealed no significant difference between prednisolone and a placebo in improving olfactory function, prompting a cautious approach to prescribing prednisolone for persistent smell disorders post-COVID-19.

Chapter 5 explores the potential benefits of olfactory training in COVID-19-induced smell loss through a case-control study, indicating statistically significant but not clinically relevant improvements in olfactory function with training. However, further research through randomized controlled trials is recommended for definitive conclusions.

In Chapter 6, we observe continued improvement of smell disorders one year after COVID-19, albeit at a slower rate, underscoring the long-term impact of COVID-19 on smell function.

Finally, Chapter 7 presents a longitudinal cohort study comparing the incidence, severity, and duration of smell and taste loss in COVID-19 versus non-COVID-19 cases. We observerd a higher incidnence and severity in COVID-19 cases, but a longer duration of having symptoms in non-COVID-19 cases.

In conclusion, this thesis provides a comprehensive understanding of COVID-19-induced smell loss, from diagnosis to long-term prognosis, emphasizing the need for continued research, awareness, and support for individuals affected by this debilitating condition, regardless the origin of their smell loss.
PENCEMARAN TANAH OLEH Pb DAN Cd DI SEKITAR TEMPAT PEMBUANGAN AKHIR (TPA) PUTRI CEMPO, KOTA SURAKARTA
Authors: Ghaida Fathassabilla Afra , Budianta Wawan
Published: April 2024

One of the impacts of rapid population growth is the problem of waste management. One of the impacts of waste disposal at the landfill is soil contamination due to heavy metals originating from waste disposed of. This study aims to determine the concentration and distribution of heavy metals in the soil laterally and vertically around Putri Cempo Landfill through spatial analysis. Sampling was carried out at 14 points with 3 different depths, namely 10 cm, 30 cm, and 60 cm. Data analysis was performed on 42 soil samples, including analysis of grain size, pH and organic content, heavy metal content, and distribution of heavy metals. The results showed that the concentrations of Pb and Cd at the three depths of the soil samples were mostly above the background values of each heavy metal. The distribution patterns of the two heavy metals laterally in the study area were relatively different, while the vertical distribution of contaminants decreased in concentration as the distance from the soil surface increased.
PENGARUH KARAKTERISTIK MINERALOGI TERHADAP KAPASITAS TUKAR KATION ZEOLIT ALAM PACITAN, JAWA TIMUR
Authors: Budianta Wawan , Warmada I Wayan , Nurudin Makruf
Published: April 2024

Penelitian ini bertujuan untuk menganalisis pengaruh komposisi mineralogi dan kimia terhadap kapasitas tukar kation (KTK) sampel zeolit alam yang diperoleh dari Pacitan, Jawa Timur. Sepuluh sampel tuf zeolitik dilakukan dianalisis komposisi mineralogi dan kimia, kapasitas tukar kation (KTK). Hasil komposisi mineralogi menunjukkan bahwa zeolit alam mempunyai jenis mordenit dominan dijumpai dalam jumlah yang yang signifikan, dengan persentase bervariasi dari 32% hingga 38%. Berdasarkan analisis kimia, kandungan kimia sampel tersusun oleh SiO2 yang berkisar antara 61% hingga 66% dan Al2O3 dari 9% hingga 11% yang kemudian diperoleh rasio antara Si/Al. Nilai kapasitas tukar kation (KTK) bervariasi dari 70 meq/100 g hingga 91 meq/100 g dengan nilai rata-rata 82 meq/100 g. Variasi nilai tersebut kemungkinan besar dipengaruhi oleh perbedaan persentase mineral zeolit dan mineral pengotor lainnya.  Zeolit jenis mordenit juga diduga paling berpengaruh terhadap kapasitas tukar kation (KTK), sedangkan mineral lempung memberikan pengaruh yang relatif kecil. Kapasitas tukar kation (KTK) kesepuluh zeolit alam yang diteliti menunjukkan korelasi positif dengan kandungan zeolit tipe mordenit serta dengan kandungan total mineral berpori dan rasio Si/Al. Hasil penelitian diharapkan dapat memberikan informasi untuk berbagai tujuan terutama di bidang pertanian dan lingkungan.
PEMANFAATAN EKSTRAK TANIN DAUN KETAPANG SEBAGAI INHIBITOR KOROSI PADA LOGAM DALAM MEDIA HCl 1 M
Authors: Nur Fitriana Salsabila  , Maulana Arfan , Widji Triana Nurul
Published: April 2024

Adanya interaksi elektrokimia dengan lingkungannya dapat menyebabkan degradasi pada suatu logam yang biasa disebut proses korosi. Selama logam berada dalam lingkungan korosif, proses korosi akan terus merusak logam dengan cara mengikisnya dan merusak kualitas mekanik dari logam itu sendiri. Tujuan penelitian ini untuk menganalisis efektivitas dan keadaan ideal inhibitor korosi ekstrak daun ketapang berdasarkan variasi penambahan konsentrasi inhibitor dan waktu perendaman. Mula-mula, daun ketapang diekstrak dengan proses maserasi selama 120 menit (suhu 850C dan pengadukan 200 rpm) dengan pelarut 1:25. Hasil ekstrak ditambahkan ke media korosi berisi logam yang kemudian direndam dengan variasi waktu perendaman tertentu untuk dihitung berat akhirnya. Variasi konsentrasi inhibitor yang digunakan adalah 700; 800; 900; 1000; dan 1100 ppm dengan lama perendaman 48, 96, 144, 192, dan 240 jam dalam larutan HCl 1M. Sampel uji dengan penambahan konsentrasi inhibitor 1100 ppm dan lama perendaman 240 jam memberikan hasil terbesar dari percobaan dengan efisiensi 39,22%.
EVALUASI KUALITAS ASET ALUN-ALUN KAWALI KABUPATEN CIAMIS
Authors: Fadjarwati Nurlaila , Senjaya Handika Adimasputra
Published: April 2024

Alun-Alun Kawali merupakan aset milik Kabupaten Ciamis yang dikelola oleh Dinas Perumahan Rakyat Kawasan Permukiman dan Lingkungan Hidup Ciamis yang terletak di kecamatan Kawali. Berdasarkan hasil survei pendahuluan yang telah dilakukan di lapangan, ditemukan indikasi masalah berkaitan dengan kualitas aset diantaranya penerangan, area duduk, dan lahan parkir. Oleh karena itu dilaksanakan evaluasi kualitas aset dengan menggunakan lima dimensi yakni Architectural, Aesthetic, Social, Environmental, dan Functional. Metode penelitian yang dilakukan yakni penelitian deskriptif dengan pendekatan kualitatif dan kuantitatif. Teknik pengumpulan data yang digunakan yakni dengan observasi dan wawancara. Hasil penilaian secara umum menunjukkan bahwa terdapat beberapa masalah pada 10 indikator dari total 16 indikator mengenai ketersediaan dan kondisi aset Alun-Alun Kawali yang masih belum sesuai dengan standar.
SISTEM PEMANTAUAN LIMBAH CAIR BERBASIS INTERNET OF THINGS DAN TERPROTEKSI WIREGUARD
Authors: Pratama Bagus Gilang , Qodri Muhammad Fatih
Published: April 2024

Air telah menjadi salah satu kebutuhan manusia yang sangat penting, terutama di sungai yang berkaitan dengan pengolahan limbah industri. Parameter kualitas limbah cair yang berkaitan erat dengan kehidupan manusia adalah kadar pH, Total Dissolve Solids (TDS), dan suhu air. Dengan kemajuan teknologi informasi, solusi cerdas untuk pemantauan kualitas air menjadi lebih populer. Penelitian ini bertujuan untuk membangun sebuah sistem pemantauan kualitas limbah cair dari hasil industri plastik berbasis teknologi Internet of Things (IoT) dan terproteksi Wireguard. Sistem pemantauan dirancang menggunakan Sensor pH Meter Analog untuk mengukur pH, Sensor TDS Meter untuk mengukur tingkat kekeruhan limbah cair, dan Sensor DS18B20 untuk mengukur suhu air. Perancangan sistem ini menggunakan jaringan wifi yang terhubung internet untuk mengirimkan data sensor ke pusat data. Untuk menjaga data agar tidak bisa dibaca oleh pihak yang tidak bertanggungjawab, sistem diintegrasikan dengan VPN Wireguard, sehingga seluruh data yang dikirimkan dari sistem pemantau akan terenkrpsi dengan sempurna dan hanya bisa dibuka oleh client yang memiliki kuncinya saja. Hasil pembacaan sensor tersebut yang telah dikirimkan ke pusat data, dapat diakses oleh pengguna terotentifikasi melalui website yang dapat diakses melalui aplikasi smartphone ataupun browser laptop. Berdasarkan hasil pengujian, sistem pemantauan dapat bekerja dengan baik untuk menatau limbah cair pada industri plastik. Selanjutnya, apabila terdapat hasil yang kurang baik untuk lingkungan mengenai limbah cair dari hasil pengukuran dapat segera ditangai sengat cepat dan efisien.
DEPOSITIONAL ENVIRONMENT STUDY OF KASAI FORMATION LEBAN AREA AND SURROUNDINGS, RANTAU PANDAN DISTRICT, BUNGO DISTRICT, JAMBI
Authors: Bagus Bagus Adhitya , Khairina Atika , Ahmad Mahbub Itang
Published: April 2024

The Leban area is one of the areas in Jambi which is very interesting for conducting geological studies related to sedimentology, tectonics and paleontology. One of the interesting objects to be reviewed is the Kasai Formation, where a description of this formation still requires further research. Here the study of the Kasai formation is viewed from its sedimentology, especially regarding the Depositional Environment. The Kasai Formation in the Leban and Surrounding Research Area, Bungo Regency, Jambi Province. From the stratigraphic cross-sectional measurements, 6 facies were found in each rock unit, namely the Planar cross-turf tuff (Sp) facies, the tuff sandstone (Sm) facies, the ripples cross lamination (Sr) sandstone facies, the very fine sandstone facies ( Sm) and the Tuff Claystone Facies (Fm).
ANALISIS MINERAL BIJIH, PARAGENESIS, DAN TEKSTUR ENDAPAN MANGAN DI DESA TEBBA KECAMATAN SALOMEKKO KABUPATEN BONE
Authors: Wakila Muhamad Hardin Wakila , Harwan  , Iqbal Rustam Muhammad
Published: April 2024

Sekitar 92% konsumsi mangan secara global berkaitan langsung dengan industri baja dan sisanya digunakan dalam aplikasi nir besi seperti baterei sel kering, bahan pewarna dan industri kimia lainnya. Provinsi Sulawesi Selatan memiliki potensi sumberdaya mangan yang tersebar di beberapa Daerah, Namun belum ditemukan penelitian tentang potensi mangan di Kab. Bone, Provinsi Sulawesi Selatan, yang mana di Desa Tebba, Kec. Salomekko, Kab. Bone ditemukan singkapan batuan pembawa mangan. Penelitian ini bertujuan untuk mengetahui mineral bijih dan asosiasi, menentukan tekstur dan paragenesis dari endapan mangan. Metode penelitian yang dilakukan yaitu pengambilan sampel, analisis Mineragrafi dan Mineral bijih yang ditemukan yaitu Pyrochorite, Pyrolusit, dan Rhodocrosite. Untuk mineral asosiasi yang ditemukan yaitu: kuarsa, albit, aragonit, klorit, arsenopirit, dan kalkopirit. Tekstur endapan mangan yaitu, tekstur Replacement dan Intergrowt. Paragenesis endapan mangan yaitu Pyrolusit tahap 1 Intergrowt tahap 2 Intergrowt. Rhodonite tahap 1 tidak ada, tahap 2 Replacement. Rhodochrosite tahap 1 Intergrowt, tahap 2 Replacement.
ALTERATION AND MINERALIZATION STUDIES IN THE JEBLOGAN AREA, KARANGTENGAH, WONOGIRI, CENTRAL JAVA
Authors: Negara Awang Subang
Published: April 2024

The research area is located in Jeblogan, Karangtengah, Wonogiri, Central Java. This study aims to investigate the hydrothermal alteration and mineralization. Geological structures present in the research area include faults and fractures. These faults are well-developed trending NE-SW, NW-SE, and N-S as pathways for fluid ascent to the surface, thereby influencing alteration patterns. Mineral alteration assemblages in the research area, based on petrographic, mineragraphy, and XRD analysis, result from hydrothermal processes and include mineral assemblage zones such as Quartz ± Silica ± Pyrite, Alunite + Pyrophyllite ± Zunyite ± Quartz ± Hematite, Illite + Halloysite ± Smectite ± Kaolinite ± Quartz, and Chlorite + Calcite + Epidote ± Pyrite. Mineralization found in the research area includes Chalcopyrite, Sphalerite, Pyrite, Chalcocite, and Galena. Based on the characteristic parameters of the deposit type and laboratory analysis, the deposit type at the research location is low-sulfidation epithermal deposit and intermediate-sulfidation deposit.
EFFECT OF USING LIME AND FLY ASH AS A CEMENT SUBSTITUTE FOR SOIL STABILITY
Authors: Dias Dwi Hatmoko  , Rifa’i Ahmad , Ismanti Sito
Published: April 2024

Subgrade is the lowest layer that receives the load on it if it does not have carrying capacity that is allowed then need for soil stabilization. Chemical soil stabilization is often done with the addition of cement but the use of cement material will cost quite high, it is necessary to alternate other materials for the substitution of cement to reduce the implementation costs incurred. Cement will be replaced as a stabilizing material in this research with additional materials like lime and fly ash. In this research, soil material was taken from the Sentul – Karawang Toll Road Project STA 24+300, with fly ash from PT PUSRI as the stabilization material, and lime material obtained from the market in Yogyakarta. The stabilization material will be used with a fixed lime percentage of 4.2% of the dry weight of the soil, and fly ash at 1.4%, 2.1%, 2.8%, 3.5%, and 4.2% of the dry weight of the soil. The soil samples were tested for physical and mechanical properties, including Standard Proctor and California Bearing Ratio (CBR). All test results were compared to select one variation, which was then designated as the Optimum Mix Design (OMD) sample. The test results of the soil sample + 4.2% lime + 2.1% fly ash yielded a CBR value of 15.52%, indicating an increase of 1078.02% from the initial 1.44%, and were formally designated as an OMD sample. The CBR value satisfies the subgrade requirements, namely >6%.
DİLDE UYUŞMA VE ÇATLAK ŞİKÂYETLERİ İLE BAŞVURAN MTHFR MUTASYONU SAPTANAN HASTA: VAKA SUNUMU
Authors: Yıldız Harun , Kılıç Mustafa
Published: April 2024

17 yaş erkek hasta dilde uyuşma ve dilinde çatlaklar şikayeti ile başvurdu. Hastanın fizik muayenesi harita dili olması dışında tamamanen normaldi. büyümesi ve gelişmesi normaldi. Yapılan labaratuvar incelelemelerinde tam kan sayımı ve rütin biyokimya testleri normaldi. B12 düzeyi normal , folik asit hafif düşük saptandı ve homosistein düzeyi yüksek olarak saptandı. Hastada etiyolojiye yönelik yapılan ileri incelemerde MTHFR geninde homozigot mutasyon tespit edildi ve tedavi başlandı. Hastaya folik asit , B12 ve betain tedavisi verildi. Tedavi ile homosistein düzeyinin kademeli düştüğü gözlemlendi. Dilde yara, harita dili gibi oral lezyonlarda B vitamini eksiklikleri pediatri pratiğinde sık akla gelen nedenlerdendir. Ancak tedavi ile düzelmeyen homosistein yüksekliğinde homosistinüri ve MTHFR mutasyonu da etiyolojide akılda bulundurulmalıdır.
MİCROBLADİNG İŞLEMİ ARDINDAN GELİŞEN SKAR SARKOİDOZU
Authors: Sarı Öznur , Kutlu Fatma Nur , Kutlu Ömer , Oğrum Atiye , Özbek Sena Buse , Akçay Elif
Published: April 2024

Özet
Skar sarkoidozu, eski travma alanlarının üzerinde gelişen, histopatolojik olarak non-kazeifiye granülomatöz reaksiyon ile karakterize, nadir görülen kutanöz sarkoidoz tipidir. Skar sarkoidozu nadir bir klinik olmasının yanı sıra sistemik sarkoidoz açısından klinisyen için uyarıcı olabilmektedir. Bu yazımızda güzellik merkezinde 5 yıl önce kaşlarına microblading işlemi (birkaç küçük iğneden oluşan küçük bir el aletinin cilde yarı kalıcı pigment eklemek için kullanıldığı bir dövme tekniğidir) ardından her iki kaşında diffüz olarak skar sarkoidozu gelişen ve sistemik tutulum açısından yapılan taramalarda pulmoner tutulumun eşlik ettiği öğrenilen otuz beş yaşında kadın bir olgu sunulmaktadır.
Sivil Patlayıcı Maddeler ile Çalışmalarda Riskler ve Risklerin Değerlendirilmesi: Bir Yeraltı Maden İşletmesi Örneği
Authors: Kun Mete , Güler Özge
Published: April 2024

Maden sektöründe ürün elde etmede sıklıkla tercih edilen bir yöntem haline gelen sivil patlayıcı maddeler ile çalışmalarda birçok tehlike bulunmaktadır. İlgili yönetmelik ve tüzükte yer alan maddeler ile birlikte uygulamada dikkat edilmesi gereken hususların takip edilmesi gerekmektedir. Patlayıcı maddeler yönetmelikte belirtilen şekilde taşınmalı ve standartlarda uygun şekilde muhafaza edilmelidir. Bu çalışmada patlayıcı madde taşıyan aracın işletmeye kabulünden başlayarak hurda patlayıcıların imhasına kadar olan sürecin tamamı incelenerek muhtemel tehlikeler ve bu tehlikelerin neden olacağı riskler belirlenmiştir. Bu amaç doğrultusunda patlayıcı madde ile çalışılan bir yeraltı maden işletmesi ele alınarak Fine Kinney risk analiz yöntemi ile riskler değerlendirilmiştir. Çalışmada risklerin tespit edilip minimalize edilmesini sağlayacak proaktif çözümlerin sunulması amaçlanmıştır. Sivil patlayıcı maddelerle çalışmalarda kimyasal, fiziksel, mekanik ve ergonomik konular hakkında tespitler yapılarak proaktif öneriler sunulmuştur. Sivil patlayıcı maddeler ile çalışmalarda yer alan risklerin genel değerlendirilmesine de ayrıca yer verilmiştir. Risk değerlendirmesi sonucunda 21 tolere gösterilemez risk, 29 esaslı risk,55 önemli risk, 16 olası risk tespit edilmiştir. Düzeltici önleyici faaliyetler sonucunda mevcut risklerin 40 olası risk ve 81 kabul edilebilir risk seviyesine geldiği gözlemlenmiştir.
EVALUATION OF LOCUST BEAN POD ASH AS MINERAL FILLER IN HOT MIX ASPHALT
Authors: Murana Abdulfatai Adinoyi , Ibedu Kenneth Ejike , Isah Abdulmumin Ahmed , Ochepo Joshua
Published: April 2024

An increase in the consumption of agricultural products generates large quantities of waste daily. The husks of the locust bean seeds when removed from the plant are littered in the environment which negatively affects the environment. In this research, locust bean pod ash (LBPA) was used as a mineral filler in hot mix asphalt. Physical and chemical tests were done on the aggregate, bitumen and LBPA, showing adequacy for use in asphalt concrete production. All tests were conducted in accordance with relevant standards. LBPA was admixed with granite dust from 0–50% (at intervals of 10%) with varying bitumen content from 4–7% (at 0.5% intervals). For this experiment, the Marshall mix design method was used. The Marshall stability of samples containing LBPA improved by 19%, from 8.16kN to 9.67kN. Similarly, Marshall flow decreased by 19% from 3.4 mm to 2.75 mm. The density-void analysis of the asphalt samples also revealed an improvement. The microstructural examination revealed an enhanced structural arrangement due to the flocculation of the LBPA particles. Overall, the hot mix asphalt samples meet the Federal Ministry of Works and Housing specifications for flexible pavement-wearing courses. It was determined by the study that adding 40% LBPA with 60% granite dust at 5% bitumen content would improve the performance of hot mix asphalt.
Techno-Economic Analysis of Biogas Production from Cow Manure
Authors: Muharja Maktum , Khotimah Husnul , Rizki Fitria Darmayanti , Andika Prastika , Achri Isnan Khamil , Badril Azhar
Published: April 2024

Biogas has been considered as a renewable alternative energy produced by anaerobic digestion of cow manure. A process of anaerobic digestion of cow manure was simulated by Aspen Plus software to analyze the cost of production. The simulated project used cow manure wastes as a feedstock. From the study, economic analysis includes Net Present Value (NPV), Internal Rate of Return (IRR), Payback period (PBP), and B/C Ratio. The resulting BEP value is 539.20, the NPV is 6,414,566,421.98, the IRR is 249.84%, and the B/C ratio is 1.66. These values can be said that the business of cow dung which is processed into biogas is feasible to run.
Phytoremediation of Cr(VI) from Aqueos Solution by Pistia stratiotes L.: Efficiency and Kinetic Models
Authors: Haeril Haeril , Sawali Fikrah Dian Indrawati , Afandy Moh Azhar
Published: April 2024

Phytoremediation utilizes metal-trapping plants to recover water as the main source of contamination, Pistia Stratiotes L. is a hyperaccumulator plant that is considered capable of reducing hexavalent chromium levels in wastewater. This is evidenced by the results obtained on each of the variables investigated, namely the effect of contact time and the number of plants. Where, the effect of contact time on the most optimal reduction in hexavalent chromium concentration on day 10 is 22.55 mg/ L with an efficiency value of 54.89 %. While the effect of the number of plants on the reduction in the most optimal metal concentration was found in the first reactor with the number of plants 4, chromium concentration was 23.16 mg/ L with an efficiency value of 54.89%. This means that the longer the phytoremediation process will affect the decrease in chromium levels in waste samples but has no effect on the number of plants used if the plant mass is not calculated before treatment. The recommended kinetic models for phytoremediation systems using P. Stratiotes L plants are Richard's Pseudo First Order and Pseudo Second Order. However, when viewed from the prediction value and experimental data, Pseudo Second Order Kinetic Models are considered suitable to describe the phenomenon that occurs in this study, with an SSE value of 1.0042 and a reaction rate constant of 1.1662 day-1 to 1.5623 day-1.
Edukasi Kesehatan Reproduksi Remaja dalam Upaya Mencegah Perilaku Seksual Berisiko di Kota Palangka Raya
Authors: Sukriani Wahidah , Wahyuni Seri
Published: April 2024

Adolescence is a transition period towards adulthood. During this period, risky sexual behavior often occurs. Palangka Raya is the capital of Central Kalimantan Province which is the third highest in child marriages in Indonesia. Information and education regarding inappropriate and correct sexuality as well as hidden messages in exposure to media containing pornographic content will increase teenagers' interest in premarital sex which can increase cases of child marriage. This community service activity aims to provide education to teenagers to understand reproductive health so that they can prevent and avoid risky sexual behavior. The method of implementing the activity is by giving a pretest, providing education about reproductive health and preventing risky sexual behavior in two stages, discussion and giving a posttest about adolescent knowledge about reproductive health to 30 activity participants. This activity was carried out at the Antang Bajenta youth posyandu in September 2022. The results of the activity showed that there was an increase in knowledge in the good category, from 13.3% to 76.7%. The conclusion is that this activity can increase teenagers' knowledge by 63.4%. It is hoped that this programs can be carried out regularly by health workers both at school and outside school, such as at youth posyandu and other youth activities.
Pendidikan Kesehatan Pencegahan Depresi pada Warga Binaan Lembaga Pemasyarakatan di Surabaya
Authors: Cempaka Anindya Arum , Lilyana Maria Theresia Arie
Published: April 2024

Correctional Inmates are at risk of experiencing significant depression twice as much as the general population. Because prisoners have psychological vulnerability because of their status as convicts with a negative impression or stigma, the purpose of this community service is as a promotive and preventive effort, especially for correctional inmates in promoting the prevention of depression so that they can achieve optimal mental health. Correctional institutions and WBP are partners in this community service. The method of community service activities is health education or counselling using the lecture method. PowerPoint media was used to support the activity's success while teaching material in leaflets was distributed after the counselling event. The activity ended with the completion of the posttest by the participants to measure the participants understanding. The indicator of the success of this activity is the increase in participants' knowledge about depression prevention. Results of the data analysis showed an influence of health education on depression prevention on the participant's level of knowledge. So it can be concluded that this activity affects the knowledge of participants. When a person receives information, it will affect the level of knowledge. In comparison, knowledge is an essential part of forming one's behaviour. Health education is expected to increase prisoners' knowledge to prevent depression while living in prison.
Pelatihan Pijat Oketani Ibu Post Partum pada Kader Kesehatan di Wilayah Kerja Puskesmas Tulehu Kabupaten Maluku Tengah
Authors: Fasiha Fasiha , Achmad Ismiyanti H. , Wabula Widy Markosia
Published: April 2024

Tulehu Community Health Centers is one of the community health centers in these work areas of the Central Maluku Regency Health Services. has 17 Posyandu with 85 active health cadres. There are IYCF Cadres who are representatives of the 17 Posyandu Health cadres. they were formed and trained in 2019. Exclusive breastfeeding coverage in the Tulehu Health Center working area is 32%, which is not yet according to the target of 40%. There were  129 babies, but only 41 people received breast milk. This happens because some mothers say that breast milk production is lacking (insufficient breast milk syndrome), so they give formula milk and additional food before  6 months,  the activity aims is to increase the knowledge and skills of cadres in helping overcome breastfeeding problems in postpartum mothers.  20 cadres were targeted in the activities. The activities carried out consisted of providing oketani massage material demonstrations and re-demonstrations followed by independent practice a home using the learning models/media provided. The post-test results showed that there was an increase in knowledge from 7.1 to 92.26 and the skills assessment results were very good, namely 97.1. This indicates a very good achievement for the participants. It is hoped that regular monitoring and evaluation by midwives of the results of the oketani massage carried out by cadres will result in the problem of breastfeeding being resolved and the coverage of exclusive breastfeeding increasing.
Penyuluhan Kesehatan Reproduksi Diet Vitamin D pada Remaja Putri di Kota Palembang dengan Dismenore Primer
Authors: Sepiwiryanti Wika , Legiran Legiran , Wardiansah Wardiansah , Effendi Kms. Yusuf , Sari Bunga Anggreini , Ramdiana Ramdiana
Published: April 2024

Primary dysmenorrhea is the most frequent gynecological issue in women of reproductive age. Various therapeutic approaches have been used to treat dysmenorrhea, such as psychotherapy, administration of non-steroidal anti-inflammatory drugs, oral contraceptive pills, and others. However, these drugs often have undesirable side effects. Therefore, other alternatives, such as herbal medicine, diet, supplements, vitamins, and minerals, are important concerns. Vitamin D, also known as calciferol, is believed to regulate cell growth and apoptosis and modulate the immune system and other functions. The active type of vitamin D has the potential to decrease prostaglandin production within the endometrium and restrict its biological impact by influencing prostaglandin receptors. Moreover, it can prompt anti-inflammatory responses through diverse pathways. Vitamin D is naturally synthesized in the skin when exposed to sunlight's ultraviolet B (UVB) radiation, but it can also be acquired from dietary sources and supplements. This community service aims to educate young women about dysmenorrhea by increasing participation in counseling. The activity method used was counseling aimed at young female students at STIKES Abdurahman in Palembang, with a total of 120 participants, and this counseling activity was carried out for 150 minutes. From the results of this community service, the students understand the importance of maintaining reproductive health. They can overcome primary dysmenorrhea by adjusting a diet that contains vitamin D.
Edukasi dan Pendampingan Keluarga dalam Upaya Cegah Perundungan di Kota Depok
Authors: Ritanti Ritanti , Permatasari Indah , Siregar Tatiana
Published: April 2024

Bullying is a complex and urgent problem. The incident is difficult to control and makes parents anxious. Family education and assistance is a service effort to the community to prevent bullying among teenagers through education and family assistance to the community in Limo Depok District. The priority problems currently faced by partners are the lack of information and knowledge related to bullying and the lack of programmed educational and mentoring activities as well as coaching youth and families related to bullying. This PKM aims to provide knowledge and understanding for families and teenagers regarding bullying and efforts to prevent it. The solution and method for implementing this PKM is through a series of activities: (1) Community meetings; (2) Preparation of media and guidebooks; (3) Communication, information, and health education (KIE) related to bullying; (4) Family assistance; (5 )Supervision and evaluation of activities. The results of this PKM activity prove that education and family assistance are effective in increasing knowledge (69.2%), attitudes (53.8%), and behavior (57.7%) of families and teenagers regarding bullying. In conclusion, the PKM program can act as a promotive and preventive medium in creating a harmonious and loving family environment and can shape the strong character of the nation's children.
A comprehensive study of prophage islands in Burkholderia pseudomallei complex
Authors: Khrongsee Pacharapong , Irby Iris , Akaphan Pitchaporn , Alami-Rose Mariam A. , Kaewrakmuk Jedsada , Tuanyok Apichai
Published: April 2024

Introduction

Bacteriophages are known as predators of bacteria and key biological factors influencing genetic recombination through phage transduction in bacteria. Phage transduction is known as one of the most common genetic recombination events found in Burkholderia pseudomallei, a diverse bacterial species and the causative agent of a deadly tropical disease melioidosis. The main objective of this study was to catalog prophages or prophage islands that are common in B. pseudomallei genomes.

Methods

Various bioinformatic tools were used to identify prophages in 106 complete B. pseudomallei genomes, and complete and incomplete genomes in other species within the B. pseudomallei Complex (BPC). Temperate phages were spontaneously induced from selected B. pseudomallei and B. thailandensis strains, and further characterized by transmission electron microscopy and whole genome sequencing.

Results

Nine phage integration hotspots were identified in B. pseudomallei pan-genomes, eight of which were associated with tRNA gene-mediated site-specific recombination (tRNA-SSR) events. These genetic events occurred at various tRNA-genes including tRNA- Phenylalanine (anticodon GAA), - Methionine (CAU), - Proline (UGG), - Arginine (UCU), - Cysteine (GCA), - Arginine (CCG), - Serine (GGA), and – Selenocysteine (UCA) genes. Some of these events were also found in other related species within the B. pseudomallei Complex (BPC). We have demonstrated that lysogenic phages from select BPC strains could use B. pseudomallei strain Bp82 or 576mn as a host. These phages were classified into one of the two major groups, myoviruses or siphoviruses, based on their morphology and genomic composition.

Discussion

We have demonstrated that most B. pseudomallei strains are lysogenic, many containing at least one functional prophage in their genomes. Further investigation of the interactions between B. pseudomallei, bacteriophages, and other environmental and biological factors would provide a bigger picture of genomic diversity, potentially influence on survival of B. pseudomallei in the environment and its pathogenic specialization in hosts.
Modulation in serum and hematological parameters as a prognostic indicator of COVID-19 infection in hypertension, diabetes mellitus, and different cardiovascular diseases
Authors: Jan Muhammad Ishtiaq , Anwar Khan Riaz , Khan Naeem , Iftikhar Syed Muhammad , Ali Sajid , Khan M. I. , Gul Saima , Nishan Umar , Ali Tahir , Ullah Riaz , Bari Ahmed
Published: April 2024

SARS-CoV-2 infection affects and modulates serum as well as hematological parameters. However, whether it modifies these parameters in the existing disease conditions, which help in the erection of specific treatments for the disease, is under investigation. Here, we aimed to determine whether serum and hematological parameters alteration in various diseases, diabetes mellitus (DM), hypertension (HTN), ischemic heart disease (IHD) and myocardial infarction (MI) conditions correlate and signal SARS-CoV-2 infection, which could be used as a rapid diagnosis tool for SARS-CoV-2 infection in disease conditions. To assess the projected goals, we collected blood samples of 1,113 male and female patients with solo and multiple disease conditions of DM/HTN/IHD/MI with severe COVID-19, followed by biochemical analysis, including COVID-19 virus detection by RT-qPCR. Furthermore, blood was collected from age-matched disease and healthy individuals 502 and 660 and considered as negative control. In our results, we examined higher levels of serum parameters, including D-dimer, ferritin, hs-CRP, and LDH, as well as hematological parameters, including TLC in sole and multiple diseases (DM/HTN/IHD/MI) conditions compared to the control subjects. Besides, the hematological parameters, including Hb, RBC, and platelet levels, decreased in the patients. In addition, we found declined levels of leukocyte count (%), lymphocyte (%), monocyte (%), and eosinophil (%), and elevated level of neutrophil levels (%) in all the disease patients infected with SARS-CoV-2. Besides, NLR and NMR ratios were also statistically significantly (p < 0.05) high in the patients with solo and multiple disease conditions of DM/HTN/IHD/MI infected with the SARS-CoV-2 virus. In conclusion, rapid alteration of sera and hematological parameters are associated with SARS-CoV-2 infections, which could help signal COVID-19 in respective disease patients. Moreover, our results may help to improve the clinical management for the rapid diagnosis of COVID-19 concurrent with respective diseases.
Incidence and risk factors of active tuberculosis among older individuals with latent tuberculosis infection: a cohort study in two high-epidemic sites in eastern China
Authors: Zhu Ping , Hao Xiaogang , Wang Wei , Wang Wei , Xu Bingjun , Zhan Bingdong , Fang Chunfu , Zhang Yating , Gao Yu , Chen Bin
Published: April 2024

Background

The influencing factors of the process from latent tuberculosis infection (LTBI) to the onset of active tuberculosis (TB) remain unknown among different population groups, especially among older individuals in high-incidence areas. This study aimed to investigate the development of active TB among older adults with LTBI and identify groups in greatest need of improved prevention and control strategies for TB.

Methods

In 2021, we implemented an investigation among older individuals (≥ 65 years old) in two towns in Zhejiang Province with the highest incidence of TB. All participants underwent assessment using standardized questionnaires, physical examinations, interferon-gamma release assays, and chest radiography. All the participants with suspected TB based on the clinical symptoms or abnormal chest radiography results, as well as those with LTBI, were referred for diagnostic investigation in accordance with the national guidelines. Those with an initial diagnosis of TB were then excluded, whereas those with LTBI were included in a follow-up at baseline. Incident patients with active TB were identified from the Chinese Tuberculosis Management Information System, and a multivariate Cox regression model was used to estimate the incidence and risk of TB among those with LTBI.

Results

In total, 667 participants with LTBI were followed up for 1,315.3 person-years, revealing a disease density of 1,292.5 individuals/100,000 person-years (17/1,315.3). For those with LTBI, chest radiograph abnormalities had adjusted hazard ratios for active TB of 4.9 (1.6–15.3).

Conclusions

The presence of abnormal chest radiography findings increased the risk of active TB among older individuals with LTBI in high-epidemic sites in eastern China.
Early GnRH-agonist therapy does not negatively impact the endometrial repair process or live birth rate
Authors: Wang Chen , Peng Yangqin , Chen Hui , Wang Qinmei , Dong Yu , Liu Huimin , Yao Yaoshan , Zhang Shunji , Li Yuan , Cai Sufen , Li Xihong , Lin Ge , Gong Fei
Published: April 2024

Study objective

To investigate whether different timings of GnRH-a downregulation affected assisted reproductive outcomes in infertile women with moderate-to-severe intrauterine adhesions (IUAs) accompanied by adenomyosis.

Design

A retrospective case series.

Setting

An assisted reproductive technology center.

Patients

The study reviewed 123 infertile women with moderate-to-severe IUAs accompanied by adenomyosis undergoing their first frozen-thawed embryo transfer (FET) cycles between January 2019 and December 2021.

Measurements and main results

The majority of patients had moderate IUA (n=116, 94.31%). The average Basal uterine volume was 73.58 ± 36.50 cm3. The mean interval from operation to the first downregulation was 21.07 ± 18.02 days (range, 1–79 days). The mean duration of hormone replacement therapy (HRT) was 16.93 ± 6.29 days. The average endometrial thickness on the day before transfer was 10.83 ± 1.75 mm. A total of 70 women achieved clinical pregnancy (56.91%). Perinatal outcomes included live birth (n=47, 67.14%), early miscarriage (n=18, 25.71%), and late miscarriage (n=5, 7.14%). The time interval between uterine operation and the first downregulation was not a significant variable affecting live birth. Maternal age was the only risk factor associated with live birth (OR:0.89; 95% CI: 0.79–0.99, P=0.041).

Conclusions

The earlier initiation of GnRH-a to suppress adenomyosis prior to endometrial preparation for frozen embryo transfer did not negatively impact repair of the endometrium after resection.