bluuebunny/crossref_metadata_2025 huggingface dataset:
Multimodality imaging of neurodegenerative disorders with a focus on multiparametric magnetic resonance and molecular imaging
Authors: Loftus James Ryan , Puri Savita , Meyers Steven P.
Published: January 2023

Neurodegenerative diseases afflict a large number of persons worldwide, with the prevalence and incidence of dementia rapidly increasing. Despite their prevalence, clinical diagnosis of dementia syndromes remains imperfect with limited specificity. Conventional structural-based imaging techniques also lack the accuracy necessary for confident diagnosis. Multiparametric magnetic resonance imaging and molecular imaging provide the promise of improving specificity and sensitivity in the diagnosis of neurodegenerative disease as well as therapeutic monitoring of monoclonal antibody therapy. This educational review will briefly focus on the epidemiology, clinical presentation, and pathologic findings of common and uncommon neurodegenerative diseases. Imaging features of each disease spanning from conventional magnetic resonance sequences to advanced multiparametric methods such as resting-state functional magnetic resonance imaging and arterial spin labeling imaging will be described in detail. Additionally, the review will explore the findings of each diagnosis on molecular imaging including single-photon emission computed tomography and positron emission tomography with a variety of clinically used and experimental radiotracers. The literature and clinical cases provided demonstrate the power of advanced magnetic resonance imaging and molecular techniques in the diagnosis of neurodegenerative diseases and areas of future and ongoing research. With the advent of combined positron emission tomography/magnetic resonance imaging scanners, hybrid protocols utilizing both techniques are an attractive option for improving the evaluation of neurodegenerative diseases.
Global prevalence of Rett syndrome: systematic review and meta-analysis
Authors: Petriti Uarda , Dudman Daniel C. , Scosyrev Emil , Lopez-Leon Sandra
Published: January 2023

Background

Rett syndrome is a rare, severe neurodevelopmental disorder. Almost all cases occur in girls, in association with spontaneous (non-inherited) mutations involving the methyl-CpG-binding protein 2 gene located on the X chromosome. Diagnostic criteria for typical Rett syndrome require a period of regression, followed by recovery or stabilization, and fulfillment of all four main criteria (loss of purposeful hand skills, loss of spoken language, gait abnormalities, and stereotypic hand movements). Our objective was to estimate the prevalence of Rett syndrome in the general population, stratified by sex.

Methods

We conducted a search of PubMed, Embase, Web of Science, Cochrane Library, LILACS, and LIVIVO to retrieve studies published in English between Jan. 1, 2000, and June 30, 2021. Pooled prevalence with a 95% confidence interval (CI) was estimated using a random-effects meta-analysis based on a generalized linear mixed model with a logit link.

Results

Ten eligible studies were identified (all in females), with a combined sample size of 9.57 million women and 673 Rett syndrome cases. The pooled prevalence estimate (random effects) was 7.1 per 100,000 females (95% CI: 4.8, 10.5, heterogeneity p < 0.001). Despite greatly variable precision of estimation, all estimates were compatible with a prevalence range of approximately 5 to 10 cases per 100,000 females based on their respective 95% CIs.

Conclusion

These findings may facilitate planning of therapeutic trials in this indication in terms of target sample size and accrual times.
Time-related meal patterns and breakfast quality in a sample of Iranian adults
Authors: Lesani Azadeh , Barkhidarian Bahareh , Jafarzadeh Mehrzad , Akbarzade Zahra , Djafarian Kurosh , Shab-Bidar Sakineh
Published: January 2023

Background

Some evidence shows that meal timing is associated with diet quality. We aimed to investigate the relationship between meal timing and breakfast quality in a sample of Iranian adults.

Methods

This cross-sectional study was conducted on 850 men and women living in Tehran, Iran. Dietary data was recorded by three non-consecutive 24-h dietary recalls. The Breakfast Quality Index (BQI) was calculated. Time-related meal patterns included the interval between the first and last meal (eating and fasting window), frequency of meals, length of sleep, and time of first and last eating occasion. The multiple linear regression analysis was used to identify the relationships between time-related meal patterns and BQI.

Results

The mean (95% CI) of BQI was 4.52 (4.45–4.65) and the maximum was 8. Bread, cheese, vegetables, fruits, energy, and carbohydrate intake showed positive associations with BQI scores. Longer fasting time showed a positive association with fruits (β (CI 95%)) (0.11 (0.0003–0.005), and vegetable consumption (0.12 (0.009–0.07)) and BQI score (0.39 (0.001–0.06)). Time of first eating occasions indicated a negative association with protein and fat intake and BQI score. Time of last eating occasions showed a positive association with vegetables consumption and BQI score. The longer length of sleep was associated with a higher BQI score. The frequency of meals was significantly and positively related to energy and macronutrients intake and BQI.

Conclusion

Earlier first and last meal, longer sleep length, longer fasting window, and a greater meal frequency were associated with a better breakfast quality.
Fluctuations in the wind energy supply do not impair acceptance of wind farms
Authors: Katsarava Mariam , Gaschler Robert
Published: January 2023

With the growing contribution of wind power to the electric energy supply, fluctuation in available wind energy might increasingly become part of public debate. Fluctuation influences energy prices and might lead to acceptance problems. As a first step to gauge potential communication strategies, we investigated in an experimental study if acceptance is influenced by being made aware of fluctuation. Participants either answered questions on acceptance before or after judging fluctuation and predictability for 30 days of wind energy input. To test for potentially biased cognition, we additionally checked if judgments were affected by whether or not it was transparent that the graphs showed wind energy input. Mean acceptance did not differ between the groups. Directing attention to the fluctuation of power generated by wind does not have an impact on acceptance. Additionally, presence or absence of labels on the graphs and thus knowing that the graphs depicted wind energy supply, did not affect fluctuation and predictability ratings.
Liberating an EFL teacher as an activist teacher professional identity in MA TESOL classrooms
Authors: Alzhrani Nesreen
Published: January 2023

This study introduces a new model of practitioner research to develop an activist teacher professional identity for student-teachers and to enhance their understanding of the theory and practice of continuous professional development (CPD). The participants were ten female student-teachers enrolled in an MA program for Teaching English to Speakers of Other Languages (TESOL) at a university in Saudi Arabia. In this intervention, student-teachers constructed their version of CPD. Then they subsequently reflected on their definition of CPD and the factors contributing to its success. Qualitative research methods were used to collect data, including document analysis and individual structured interviews. The study sought to discover how the enquiry intervention improved student-teachers’ grasp of CPD theory and practice and contributed to the construction of their activist teacher professional identity. The findings may encourage the development and implementation of new forms of practitioner enquiry in MA programs to support the construction of different notions of professional identity found in the literature.
Psychosocial impact of COVID-19 2 years after outbreak on mental health of medical workers in Iran
Authors: Kolivand Pirhossein , Hosseindoost Saereh , Kolivand Zahra , Gharaylou Zeinab
Published: January 2023

Background

The COVID-19 pandemic had a substantial influence on the mental health of healthcare workers. This study investigated general health status, the prevalence, and the severity of depressive spectrum and anxiety-related disorders. It evaluated the association between various factors and depression, anxiety, and stress among healthcare workers in the Khatam-Alanbia Hospital in Iran, after 2 years since the corona virus disease 2019 (COVID-19) pandemic.

Results

In this online cross-sectional study, 409 participants were selected and given a questionnaire about demographic, personal, and clinical characteristics as well as stressors related to COVID-19. The participants completed the General Health Questionnaire (GHQ-28) and the 42-item Depression, Anxiety, and Stress Scale (DASS-42) to report depression, anxiety, and stress/tension levels. We found that the overall incidence of depression, anxiety and stress among health care workers during the COVID-19 pandemic was 44.25%, 50.62%, and 43.76%, respectively. Participants with severe to very severe depression, anxiety and stress accounted for 19.2%, 26.6%, and 18.2% of the sample, respectively. Being female was associated with higher odds of depression, anxiety, and stress.

Conclusions

Two years after the COVID-19 outbreak, health workers are still showing a significant level of depression, anxiety, stress, and remarkable signs of psychological distress. The situation of a health care worker is worrying. The long-term psychological implications of infectious diseases should not be ignored. Mental health services could play an essential role in rehabilitation.
Somatic comorbidities of mental disorders in pregnancy
Authors: Khachadourian Vahe , Kodesh Arad , Levine Stephen Z. , Lin Emma , Buxbaum Joseph D. , Bergink Veerle , Sandin Sven , Reichenberg Abraham , Janecka Magdalena
Published: January 2023

Background

Mental and physical health conditions are frequently comorbid. Despite the widespread physiological and behavioral changes during pregnancy, the pattern of comorbidities among women in pregnancy is not well studied. This study aimed to systematically examine the associations between mental and somatic disorders before and during pregnancy.

Method

The study used data from mothers of a nationally representative birth cohort of children born in Israel (1997–2008). We compared the risk of all major somatic disorders (International Classification of Diseases, Ninth Revision) in pregnant women with and without a mental disorder. All analyses were adjusted for maternal age, child’s birth year, family socioeconomic status, and the total number of maternal encounters with health services around pregnancy period.

Results

The analytical sample included 77,030 mother–child dyads, with 30,083 unique mothers. The mean age at child’s birth was 29.8 years. Prevalence of diagnosis of mental disorder around pregnancy in our sample was 4.4%. Comorbidity between mental and somatic disorders was two times higher than the comorbidity between pairs of different somatic disorders. Of the 17 somatic disorder categories, seven were positively associated with mental health disorders. The highly prevalent comorbidities associated with mental disorders in pregnancy included e.g. musculoskeletal (OR = 1.30; 95% CI = 1.20–1.42) and digestive system diseases (OR = 1.23; 95% CI = 1.13–1.34).

Conclusions

We observed that associations between maternal diagnoses and mental health stand out from the general pattern of comorbidity between nonmental health diseases. The study results confirm the need for screening for mental disorders during pregnancy and for potential comorbid conditions associated with mental disorders.
Patient-specific variants of NFU1/NFU-1 disrupt cholinergic signaling in a model of multiple mitochondrial dysfunctions syndrome 1
Authors: Kropp Peter A. , Rogers Philippa , Kelly Sydney E. , McWhirter Rebecca , Goff Willow D. , Levitan Ian M. , Miller David M. , Golden Andy
Published: January 2023

Neuromuscular dysfunction is a common feature of mitochondrial diseases and frequently presents as ataxia, spasticity and/or dystonia, all of which can severely impact individuals with mitochondrial diseases. Dystonia is one of the most common symptoms of multiple mitochondrial dysfunctions syndrome 1 (MMDS1), a disease associated with mutations in the causative gene (NFU1) that impair iron–sulfur cluster biogenesis. We have generated Caenorhabditis elegans strains that recreated patient-specific point variants in the C. elegans ortholog (nfu-1) that result in allele-specific dysfunction. Each of these mutants, Gly147Arg and Gly166Cys, have altered acetylcholine signaling at neuromuscular junctions, but opposite effects on activity and motility. We found that the Gly147Arg variant was hypersensitive to acetylcholine and that knockdown of acetylcholine release rescued nearly all neuromuscular phenotypes of this variant. In contrast, we found that the Gly166Cys variant caused predominantly postsynaptic acetylcholine hypersensitivity due to an unclear mechanism. These results are important for understanding the neuromuscular conditions of MMDS1 patients and potential avenues for therapeutic intervention.
Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae
Authors: Allers Maaike , Bakker Petra A. , Hoeksma Jelmer , Spaink Herman P. , den Hertog Jeroen
Published: January 2023

PTPN6 encodes SHP1, a protein tyrosine phosphatase with an essential role in immune cell function. SHP1 mutations are associated with neutrophilic dermatoses and emphysema in humans, which resembles the phenotype seen in motheaten mice that lack functional SHP1. To investigate the function of Shp1 in developing zebrafish embryos, we generated a ptpn6 knockout zebrafish line lacking functional Shp1. Shp1 knockout caused severe inflammation and lethality around 17 days post fertilization (dpf). During early development, the myeloid lineage was affected, resulting in a decrease in the number of neutrophils and a concomitant increase in the number of macrophages. The number of emerging hematopoietic stem and progenitor cells (HSPCs) was decreased, but due to hyperproliferation, the number of HSPCs was higher in ptpn6 mutants than in siblings at 5 dpf. Finally, the directional migration of neutrophils and macrophages was decreased in response to wounding, and fewer macrophages were recruited to the wound site. Yet, regeneration of the caudal fin fold was normal. We conclude that loss of Shp1 impaired neutrophil and macrophage function, and caused severe inflammation and lethality at the larval stage.
ULK1-mediated phosphorylation regulates the conserved role of YKT6 in autophagy
Authors: Sánchez-Martín Pablo , Kriegenburg Franziska , Alves Ludovico , Adam Julius , Elsaesser Jana , Babic Riccardo , Mancilla Hector , Licheva Mariya , Tascher Georg , Münch Christian , Eimer Stefan , Kraft Claudine
Published: January 2023

Autophagy is a catabolic process during which cytosolic material is enwrapped in a newly formed double-membrane structure called the autophagosome, and subsequently targeted for degradation in the lytic compartment of the cell. The fusion of autophagosomes with the lytic compartment is a tightly regulated step and involves membrane-bound SNARE proteins. These play a crucial role as they promote lipid mixing and fusion of the opposing membranes. Among the SNARE proteins implicated in autophagy, the essential SNARE protein YKT6 is the only SNARE protein that is evolutionarily conserved from yeast to humans. Here, we show that alterations in YKT6 function, in both mammalian cells and nematodes, produce early and late autophagy defects that result in reduced survival. Moreover, mammalian autophagosomal YKT6 is phospho-regulated by the ULK1 kinase, preventing premature bundling with the lysosomal SNARE proteins and thereby inhibiting autophagosome–lysosome fusion. Together, our findings reveal that timely regulation of the YKT6 phosphorylation status is crucial throughout autophagy progression and cell survival.
Fe, N-Doped SrTiO3 Synthesized Using Pyrazine Carboxylic Acid-Metal Complexes: Application as an Oxygen Reduction Catalyst for Polymer Electrolyte Fuel Cell Cathodes in Acidic Media
Authors: Takeuchi Yuu , Matsuzawa Koichi , Nagai Takaaki , Ikegami Kaoru , Kuroda Yoshiyuki , Monden Ryuji , Ishihara Akimitsu
Published: January 2023

Fe, N-doped SrTiO3 was successfully synthesized using pyrazine carboxylic acid-metal complexes as the starting materials and exhibited high onset potential of 0.8 V vs. RHE for the oxygen reduction reaction because of the formation of high-quality active sites by Fe and N doping, and electron conduction paths by carbon nanotubes.
Λιμπρέτα ελληνικής και γαλλικής οπερέτας κατά την περίοδο του Μεσοπολέμου
Authors: Νικήτα Παρασκευή
Published: January 2023

Ερευνητικό αντικείμενο της διδακτορικής διατριβής αποτελούν τα λιμπρέτι της ελληνικής και γαλλικής Οπερέτας κατά την περίοδο του Μεσοπολέμου. Στόχος της είναι να παρουσιαστούν οι ευρύτερες και οι επιμέρους θεματικές που τα λιμπρέτι πραγματεύονται, σε συνάρτηση με την κοινωνικοοικονομική μεταβλητότητα της χώρας στο Μεσοπόλεμο, προκειμένου να αναδειχθούν τα δραματουργικά της χαρακτηριστικά και να επαναπροσδιορισθεί η αξία και η συμβολή της και κατά προέκταση η συμβολή του ελαφρού μουσικού θεάτρου στην ιστορία του νεοελληνικού θεάτρου. Η πρωτογενής ερευνητική δραστηριότητα φέρνει στο φως 127 λιμπρέτι ελληνικής οπερέτας αγνοημένα μέχρι σήμερα, κείμενα τα οποία φυλάσσονται σε ιδιωτικά και δημόσια αρχεία στην ελληνική επικράτεια. Στη διατριβή εξετάζονται τα κυριότερα θέματα και οι χαρακτηριστικότεροι τύποι που συναντώνται στα λιμπρέτι. Ειδικότερα, παρουσιάζεται η Γυναίκα, σε συνάρτηση με την άνοδο του φεμινιστικού κινήματος και τις διεργασίες του για την αναβάθμιση του ρόλου της στην κοινωνία, μέσα από την εκπαίδευση, την εργασία και τη διεκδίκηση ίσων δικαιωμάτων. Αντίστοιχα, ο Άνδρας σε παραλληλία με την πολιτική, την προσφυγική έλευση και τις κοινωνικές και οικονομικές μεταβολές της χώρας. Τα δίπολα Αθήνα- Επαρχία και Φτώχεια- Πλούτη, μέσα από την παρουσίαση των κυριότερων χώρων δράσης των έργων και μέσα από τη σύγκριση των κατώτερων και ανώτερων κοινωνικών στρωμάτων και τα ιδιαίτερα χαρακτηριστικά που οι δημιουργοί αποδίδουν στους ήρωές τους, σε συνάρτηση με την καταγωγή και την κοινωνική τους τάξη. Διερευνώνται επίσης τα επιμέρους χαρακτηριστικά της Οπερέτας: η σύνδεσή της με το Κωμειδύλλιο και την Επιθεώρηση, ο ρόλος της μουσικής ως συνδραματουργός, οι θεματικές συνδέσεις με το μεσοπολεμικό θέατρο πρόζας και τον μεταπολεμικό κινηματογράφο. Τέλος, παρουσιάζεται η πορεία της γαλλικής Οπερέτας στη χώρα και επιχειρείται μια πρώτη παρουσίαση των κυριότερων θεματικών των έργων γαλλικής Οπερέτας που ανέβηκαν στην ελληνική μεσοπολεμική σκηνή. Η διατριβή συνοδεύεται από παράρτημα με πίνακες των τύπων Γυναίκας και Άνδρα και με μια επιλογή περιλήψεων των έργων ελληνικής Οπερέτας.
Impact of clinical factors on hospital stay and hospital readmission rate after acute exacerbation of COPD: a retrospective cross-sectional study
Authors: Chaurasiya Prem Shankar , Lamsal Dinesh Kumar , Khatri Akash , Aryal Laxmi
Published: January 2023

Background: Chronic obstructive pulmonary disease (COPD) is a condition with high morbidity and cost to health services due to a high number of exacerbations necessitating multiple and prolonged hospitalizations. The length of hospital stays and hospital readmission rate is related to patient age, sex, disease severity, current smoking status, comorbidities, dyspnea grade, carbon dioxide partial pressures, use of mechanical ventilation, previous exacerbation, long-term oxygen therapy, and inpatient diuretics use. The purpose of the study was to identify the differential effects of patient and treatment-related factors on the length of hospital stay and hospital readmission for COPD exacerbation-related admissions.

Methods: A hospital-based retrospective cross-sectional study was conducted among 151 patients with acute exacerbation of COPD admitted at Civil Service Hospital, Kathmandu from August 2021 to March 2022. Ethical approval was taken from the Institutional Review Committee, Civil Service Hospital (Reference no. 18/ 2022). A convenience sampling method was followed. Data regarding different clinical factors were collected in a semi-structured questionnaire. The data were entered and analyzed through Microsoft Excel 365 and SPSS version 22.0 using a binary regression model.

Results: Comorbidities, current smoking, dyspnea grade mMRC IV, mechanical ventilation, and long-term oxygen therapy were significantly associated with prolonged hospital stays for COPD exacerbation-related admissions. The corresponding odd ratio is (OR 3.4, 95% CI: 1.24–9.29); (OR 21.4, 95% CI: 6.17–74.57); (OR 2.5, 95% CI: 1.20–5.45); (OR 5.6, 95% CI: 1.20–26.35); (OR 2.4, 95% CI: 1.02–5.90), respectively.

Conclusions: The effect of clinical factors such as comorbidities status, current smoking habits, higher grade of mMRC dyspnea scale, mechanical ventilation, and long-term oxygen therapy needed to be considered to optimize care for COPD patients needing hospital admissions and hence decrement in hospital costs.
Second-line drug resistance markers as proxy indicators of time to sputum culture conversion among second-line drug resistant tuberculosis patients tested in Uganda: A cross-sectional study
Authors: Mujuni Dennis , Ssengooba Willy , Ibanda Ivan , Kabugo Joel Solomon , Kasemire Dianah Linda , Nampewo Elizabeth , Nsawotebba Andrew , Phelan Jody E , Tugumisirize Didas , Orena Beatrice , Byabajungu Henry , Ntenkaire Nathan , Nadunga Diana , Tumwine Julius , Musisi Kenneth , Joloba Moses , Kim Seungmo , Kokas Ikwap , Mukani William Olaho , Kungu Joseph , Afayoa Mathias
Published: January 2023

Background

Increased tuberculosis disease burden arises as a result of low treatment success rates stemming from the emergence of second-line drug resistance. We aimed at determining the usefulness of second-line drug (SLD) resistance markers as proxy indicators of time to sputum culture conversion; a renowned predictor of Tuberculosis treatment outcome, among SLD-resistant tuberculosis (TB) patients tested at the Uganda National TB Reference Laboratory (NTRL).

Methods

A cross-sectional study was conducted on 72 bacteriologically confirmed SLD resistant TB patients with datasets including culture conversion time and second line probe assay mutation profiles between 01/06/2017 and 31/12/2019. The data were then imported into STATA v15 for descriptive statistical analysis, Univariate cox proportional hazard model analysis and Kaplan-Meier survival curves at a 5% level of significance; p-value ≤0.05.

Results

Results indicate the median time was achieved at 3 (0–12) months across the studied patients. The rrs G1484T mutation associated with conferring drug resistance to injectable agents was observed to have the shortest median conversion time of 1.5 months, longest by the gryB E540D at 5 months. A single mutation in the gryA gene locus showed higher converted proportions 70.8% (58.9–81.0) than those that had two 8.3% (3.1–17.3) or three 2.7% (0.3–10.0) mutations.

Conclusions

The studied second-line drug resistance markers had no statistically significant association with the time to sputum culture conversion, although increased drug resistance levels reduced the converted proportions and stressed the need to utilize molecular diagnostics data and other crucial variables to better comprehend proxy indicators of SLD resistant tuberculosis management.
Algal-derived macromolecules and their composites: From synthetic biology to biomedical applications in bone and cardiovascular tissue engineering
Authors: Nurkolis Fahrul , Taslim Nurpudji Astuti , Hardinsyah Hardinsyah , Mayulu Nelly , Khumaidi Mohammad Adib , Gunawan William Ben , Joseph Victor F. F. , Herlambang Bagus , Hendra Ikra Wiratama , Tanjaya Krisanto , Nojaid Ammar , Yusuf Vincentius Mario , Permatasari Happy Kurnia , Samtiya Mrinal , Tallei Trina Ekawati
Published: January 2023

Algae have shown numerous advantages as biofunctional and bioactive material sources. The development of biosynthetic or synthetic materials has enabled algal-derived macromolecules and their derivatives to be used in biomedical applications. This review examines and analyzes the most recent developments in the production of biomaterials from algal-derived macromolecules and their composites and their potential applications in bone and cardiovascular tissue engineering. Several macromolecules derived from algal polysaccharides, including sulfated polysaccharides, fucoidans, and fucans, have been developed for cartilage, intervertebral disc, bone, and skeletal muscle transplants because of their stable structures. Alginates, fucoidans, chitin, porphyrin, and other algal polysaccharide derivatives have been investigated for engineering blood vessels, heart valves, and even the liver. One advantage of algal-derived macromolecules and composites is their safe immunity properties. This review also highlights cutting-edge developments in applying algal-derived macromolecules with a broader biomedical scope to encourage in-depth research into their potential as biomaterial scaffolds in medical applications.
Cefepime-induced neurotoxicity after flap surgery: a rare case report
Authors: Song Woo Jin , Lee Chan Yeong , Ryu Hyeong Rae , Byeon Je Yeon , Choi Hwan Jun
Published: January 2023

Cefepime is a fourth-generation cephalosporin that covers gram-positive bacteria and gram-negative bacteria, such as Pseudomonas. A 48-year-old male patient underwent a posterior tibial artery perforator-based fasciocutaneous turnover flap and was administered cefepime. After 2 days, the patient showed neurological symptoms, such as cognitive decline and aphasia. We immediately stopped cefepime and changed to ciprofloxacin. In addition, thiamine was administered and additional dialysis was performed. The neurological symptoms were resolved after tapering cefepime and hemodialysis. In patients undergoing flap surgery, especially those with impaired renal function, cefepime should be administered carefully considering the risk of neurotoxicity.
Negotiated Order in Mut’ah Marriage
Authors: Pinkan Dias Regan , Farihanto Muhammad Najih , Hakim Lukman
Published: January 2023

Marriage, as defined by Law No.1/1974, is an inner and outer relationship between a man and a woman with the goal of building a joyful and eternal family (home) based on the One Godhead. However, there are various social phenomena that occur in the society with specific goals that are structured in a marriage process known as mut'ah marriage or contract marriage. In this study, the author attempts to evaluate mut'ah marriage from a sociological standpoint using a social definition paradigm and the perspective of symbolic interactionism, specifically negotiated orders. This research is a library research. As a result, actors face a variety of incentives ranging from the economic to the social which can then cause damage at the stage of the basis of action to the stage of consumption or action. Two forms of negotiation were also found to justify mut'ah marriage, namely the negotiation of the rational dimension and the negotiation of the economic dimension.
Application of Communication on the Corporate Social Responsibility model in a Company
Authors: Dwi Setiawan Resdika Anggesa , Chang Jiang
Published: January 2023

Various Corporate Social Responsibility activities must of course be conveyed appropriately and according to the wishes expected for the surrounding community. The purpose of writing this article is to see how the implementation of CSR activities in several companies in Indonesia by doing good communication for the program. The method used in this paper is to show several cases of CSR implementation in Indonesia for descriptive analysis. The results to be obtained are knowing if the two-way communication model is more effective in delivering CSR programs to the community, because this delivery is able to provide feedback between the company and the community, so that the community gets positive benefits from the company's business industry activities and the company can also assess the response positive or negative of the program that will be made or has been implemented in the local community.
From horizontal to vertical Film changes in mise en scene
Authors: Nabella Gabriella Rizka
Published: January 2023

A vertical film that has an aspect rasio 9:16. X&Yvertical film is Indonesia’ first vertical film to be uploaded on the Tiktok platform. The purpose of this study used the descriptive qualitative method. Data collection techniques: data reduction, data presentation, and drawing conclutions. This study uses observation and documentation methods as data collection techniques. The study result indicate that it is different from the horizontal film. X&Y vertical film often maximize top-down framing. The framing logic that changes in X&Y vertical film determines the type of size shot used. When applied to the vertical film, the size shot on the horizontal film will be different. X&Y film use a lot of size shot, such as medium closeup and close up. Using medium shots and medium closeup in the vertical film gives the audience a solid and intimate impression. Changes bin shot size will also affect the composition of the mise en scene elements. In addition, there are also adjustments to mise en scene elements such as lighting, setting, properies, blocking, and actors. X&Y film uses a lot of composition and top-down blocking to take advantage of the height of the vertical framing. The top and bottom spots appear in a vertical frame. X&Y movie only on the Tiktok platform. There are not many media that support viewing in a vertical format.
Strengthening Media Literacy through Educational Radio at Muhammadiyah Piyungan High School
Authors: Octiyandri Dhea
Published: January 2023

Media literacy is the ability to know the various forms of different media and understand the purpose of their use. The purpose of this study was to analyze the strengthening of media literacy through educational radio at Muhammadiyah Piyungan high school and to determine the ability of students to use educational radio as a learning medium. This research uses descriptive qualitative method. Data collection techniques used are observation and interviews. There are three types of data analysis techniques used, namely, data reduction, data presentation, and drawing conclusions. Based on the results that have been researched, it shows that understanding of media literacy for Muhammadiyah Piyungan High School students in the learning process using educational radio is still not optimal. Not only in technical terms which have not been maximized but, analyzing the information obtained, evaluating, creating or understanding the content created, as well as teachers who have not been maximized, because there are no teachers who are experts in the field of radio. So that students at Muhammadiyah Piyungan high school learn independently. Constraints faced by students in creating content and understanding the contents of the manuscript are due to the limited knowledge of the students. The next obstacle is that Muhammadiyah Piyungan high school does not yet have a special assistant or teacher who understands educational radio as a learning medium. In addition, Muhammdiyah Piyungan high school does not yet have a role model that can be used as an example for learning, so that makes students slow to understand this educational radio.
Green Zone Tourism Promotion Strategy of the Bali Government Tourism Office in 2021
Authors: Mariana I Ketut Adi , Sofyan Nur
Published: January 2023

Indonesia is a country that has a variety of natural charms that everyone can enjoy in the tourism sector. However, the pandemic caused by Covid-19 so far has not subsided, which of course, most people in Bali who depend on the tourism sector lose their jobs and even do not get a livelihood for their living needs. From that, The Ministry of Tourism and Creative Economy of the Republic of Indonesia appointed Bali Province as one of the provinces implementing the green zone program to support the recovery of the tourism economy. Implementing the tourism recovery plan in the province of Bali is carried out in stages. The government has designated three areas in Bali as green zones: Ubud, Sanur, and Nusa Dua. It is essential to see the strategy of the Bali Government Tourism Office in promoting the green zone as an effort for tourism recovery. This study aims to identify and describe the marketing communication strategy of the Bali Government Tourism Office in introducing a green zone as an effort for tourism recovery in 2021. This research will offer new wealth in the research related to marketing communication strategies that focus on the green zone sector in Indonesia. A qualitative descriptive study was conducted to examine green zone efforts for tourism recovery based on the marketing communication strategy concept. Findings revealed that the Bali Government Tourism Office adopted at least more than one of the tourism destination marketing communication mixes to promote green zone as an effort for tourism recovery in 2021. In addition, the Bali Government Tourism Office was also considering the pentahelix stakeholder model, where the five stakeholders in the model are invited to discuss how to make the program successful.
Political Marketing Communication Strategy of Budi Prayitno in Facing the 2019 Magelang City DPRD General Election
Authors: Reyhan Muhammad Naufal , Sofyan Nur
Published: January 2023

This study analyzes Budi Prayitno's political marketing strategy in the contestation of the Legislative Election of the Magelang City DPRD. This study focuses on the political marketing strategy carried out by Budi Prayitno as a senior legislative candidate from the PDI-P Party in carrying out political marketing. The presence of Budi Prayitno as a senior figure is evidenced by his tenure as a member of the Magelang City DPRD for 3 terms from the PDI-P Party. In this study, the author uses a 3P approach model (push marketing, pass marketing and pull marketing). The research findings show that the political marketing strategy implemented by Budi Prayitno is structured and directed according to the target. Some of the political marketing strategies used by Budi Prayitno, including: first, blusukan or campaigns that go directly to the public as Push Marketing. Second, the use of community groups and political parties as a marketing pass. Third, the use of social media as pull marketing. This study aims to determine Budi Prayitno's Political Marketing in Facing the 2019 Magelang City DPRD General Election. The type of research used in this study is a case study qualitative research. The data and information needed in this study were obtained from information from informants, namely people who are considered to know and can be trusted in providing accurate information by using two types of data, namely primary data and secondary data. Data collection techniques in this study were direct observation to the research site, in-depth interviews and documentation at the research site. The results of this study indicate that Political Marketing Budi Prayitno in Facing the General Election of Members of the DPRD City of Magelang in 2019 used a political marketing approach (push marketing, pull marketing, and pass marketing) to increase his voting bar because in yesterday's election there were several promises politics that he did not realize when he served as chairman in the previous period.
Genetic Diversity and Molecular Breeding of Melon (Cucumis melo L.): A review
Authors: Komala Majjiga , Kuni Pragathi
Published: January 2023

Cucumis melo L. is an important horticultural crop that is widely cultivated for its edible fruit. The breeding of melon crop in order to improve its qualitative and quantitative yield is the objective of the current research. The recent melon breeding majorly focused on identification of novel genes, novel QTLs, and differentially expressed genes among the various populations. The publication of melon genome sequence in 2012, substantially accelerated the genetic dissection of candidate genes responsible for various desirable traits such as yield and yield contributing traits, fruit quality, disease resistance (Powdery mildew and Downey mildew resistance), salinity and temperature stress, and the genes involving in melon plant physiology. The molecular biology approaches such as whole-genome resequencing, bulked segregant analysis sequencing and the transcriptome analysis have been widely used to explore the genetic basis for the observed desirable phenotypic characteristics of the melon accessions in the germplasm to further aid in future molecular breeding of melon. Here, we summarized such research reports and categorized them under various sub sections. Overall, this current review presents the overview of very recent advances in melon crop improvement and developments in melon molecular breeding approaches as well as it provides the future directions for melon breeding. It would probably provide recent updates on melon crop improvement and help melon breeders to plan for their future breeding programmes.
Biofertilizer: An Ultimate Solution for the Sustainable Development of Agriculture
Authors: Verma Preeti , Pandey Kunal
Published: January 2023

Global warming and climate change are the most potent cause of natural disasters like droughts, high temperature, extreme cold in some places, rising ocean level. One of the most important cause of these disasters are poor cropping patterns and extensive use of agrochemicals. These chemical fertilizers increase the level of salts in the soil and also make the soil acidic. In the era of modern agriculture the use of pesticides and chemical fertilizers to increase the production of food across the globe deteriorated the original productivity of soil. These chemical fertilizers are like instant food for plant because they instantly provide nutrition to the plants and help the plant to grow rapidly and at a faster pace. Chemical fertilizer are nutrients which are readily soluble and instantly available to plants, therefore usually the effect is direct and fast. Due to its high nutrient content, only relatively small amount are required for crop development and growth. Over application can result in harmful effects such as leaching, water resource pollution, microorganism and friendly insect’s destruction. The substitute to chemically made fertilizers are naturally occurring microorganisms that can be grown and multiply in laboratories to produce biofertilizers, which can serve as an efficient, effective and economical way for the better production of crops when World Health Organization has predicted that the population will be increased to 9.6 billion in the next 30 years and the food production should be increased by 50 percent. In recent years the biofertilizer emerged as a potential component to fix the nitrogen present in air and solubilize the phosphorous and promote plant growth. And also, these biofertilizers have the ability to make the environment clean by bioremediation. These plant growths promoting microorganisms (PGPMs) like bacteria, algae and fungus promote the sustainable development approach provided by United Nations Climate Change Conference (COP 21) which was held in Paris in 2015. The study reviews these efficient, eco-friendly, economical and sustainable nutrients which have the potential for the better production of crops, and it is based on several relevant literatures and reviews and research work carried out by several prominent researchers in this field.
Comparación de anticuerpos postvacunales al SARS-CoV-2 en casos asintomáticos, casos sintomáticos, y no casos de una cohorte de trabajadores de un hospital general
Authors: Sabater Vidal Susana , Tirado-Balaguer María Dolores , Soria-Martín Raquel , Arnedo-Pena Alberto , Gil-Galdón Abel , Moreno-Muñoz Rosario , Bellido-Cambrón Mª Carmen
Published: January 2023

Estimada Sra. Directora:
Agradecemos a los doctores Rujittika Mungmunpuntipantip y Viroj Wiwanitkit su interés por nuestra publicación(1) en la carta en la que se subrayan la importancia de los casos asintomáticos de COVID-19 en la evaluación de los efectos de la vacunación anti-SARS-CoV-2(2). Compartimos con ellos que las personas asintomáticas al COVID-19 pueden presentar unos niveles de anticuerpos anti-SARS-CoV-2 IgG-S mayores que las personas sin historia previa de COVID-19, y que pueden diferir en las reacciones a la vacunación, considerando que la prevalencia de COVID-19 asintomáticos se ha descrito como elevada(3). 
En nuestra cohorte de trabajadores del Hospital General Universitario de Castellón, se detectaron 5 casos de COVID-19 asintomáticos (CA), incluyendo los dos seguimientos realizados(1,4), y 20 casos presentaron síntomas de COVID-19 (CS), con un total de 25 casos con confirmación por el laboratorio, 20 % tasa de asintomáticos (5/25). En la tabla 1 se recogen las características de los CA, CS, y de los participantes que no habían sufrido la enfermedad. Los CA eran más jóvenes que los otros 2 grupos, y la proporción de varones era significativamente mayor (p=0,027). En cuanto a los anticuerpos Anti-SARS-CoV-2 IgG-S al mes de la vacunación, los niveles de los CS fueron mayores que los de CA, y de los no casos, siendo estos últimos los que tuvieron significativamente menores niveles (p<0,001). Sin embargo, a los 8 meses de la vacunación la caída de IgG-S fue general, y los niveles de IgG-S eran mayores en los CA que en los CS y en los no casos (p<0,001). Los niveles de IgG-S considerados como protectores ? 4160 UA/ml, eran mayores en los CA y CS que el de los no casos (p=0,001). Si bien, el declive era similar en los tres grupos (p=0,084). Los síntomas y los efectos secundarios de las dos dosis de vacuna Pfizer-BioNTech no presentaron diferencias significativas entre los grupos.
Estos resultados son coincidentes con númerosos estudios, en los que se constata que los casos de COVID-19 presentan niveles más elevados de IgG-S que las personas que no han sufrido la enfermedad(5), y se apreció que en valores medio no se alcanzaron los niveles de IgG-S protectores. De aquí la importancia de disponer de marcadores más efectivos de la situación de protección de la personas vacunadas tanto si han sufrido la enfermedad como sino. Además de los anticuerpos neutralizantes, la determinación de la inmunidad celular podría ser muy conveniente para conocer los niveles de protección.
THE INDUSTRIALISATION OF GRAPHENE
Authors: HEDGES PAUL
Published: January 2023

Industrialising graphene and the future of Moore's Law.
SENSOR SELECTION
Authors: LORENZ MARKUS
Published: January 2023

With the rise of collaborative machines where do you start when it comes to selecting the right sensors for cobots?
Edge Data Centres Need Embedded Server Technologies
Authors: Loncaric Zeljko
Published: January 2023

Reduced latency and energy consumption in long-distance data traffic will require computing power at the edge, meaning that embedded and server technologies need to converge.
The New Face of Policing
Authors: Tyler Neil
Published: January 2023

At a time when criminals are becoming more sophisticated how are the police using technology to respond?
Master of the Universe
Authors: Tyler Neil
Published: January 2023

This year’s Technology Symposium highlighted TSMC’s dominance of the semiconductor market and, considering its investment plans, that’s likely to continue for some time.
Demystifying Medical Alarm Designs
Authors: Kumar Uttama
Published: January 2023

Using smart DACs can help in the design of complex medical alarms, as a team from Texas Instruments explains to New Electronics
Audio Edge Processing
Authors: Senguttuvan Raj
Published: January 2023

Solving the challenges of audio source classification in the Smart Home, by Raj Senguttuvan and Vikram Shrivastava
No Space Wasted
Authors: Tyler Neil
Published: January 2023

SCIENTISTS EMBED CAPACITORS INTO INTERPOSERS REDUCING PACKAGE AREA.
Silicon Catalyst Launches UK-Based Accelerator
Authors: Tyler Neil
Published: January 2023

SILICON CATALYST, THE WORLD'S ONLY INCUBATOR FOCUSED EXCLUSIVELY ON ACCELERATING SOLUTIONS IN SILICON, ANNOUNCES SILICONCATALYST.UK.
MediaTek Unveils 4K Smart TV Chip
Authors: Tyler Neil
Published: January 2023

MEDIATEK LOOKS TO USHER IN AI-ENABLED INTERACTIVE MULTIMEDIA EXPERIENCES.
Semiconductor Design is Set to Look Very Different
Authors: Munsey Michael
Published: January 2023

What are the current challenges confronting semiconductor design, and how is the industry looking to address them?
ARM Unveils V9 Architecture
Authors: Tyler Neil
Published: January 2023

ARM INTRODUCES THE ARMV9 ARCHITECTURE IN RESPONSE TO GROWING DEMAND FOR IMPROVED SECURITY AND THE INCREASED DEPLOYMENT OF AI.
Living with Lithium
Authors: Gallinaro Stefano
Published: January 2023

How advanced battery management is being used in healthcare energy storage systems.
Production technology CHALLENGES
Authors: Dück Jakob
Published: January 2023

The challenges associated with meeting the needs of customers are now extending more deeply into the production process, as Jakob Dück explains
Early Detection
Authors: Johnston Philip
Published: January 2023

A length-unlimited flexible printed circuit technology is enabling a robust, precise and early oil leak detection system.
Novel Testing Metrics
Authors: Eichler Taro , Philipp Ute , Rädler Lorenz
Published: January 2023

What are the innovative test metrics being developed for 5G mmWave device performance verification? TARO EICHLER, UTE PHILIPP and LORENZ RÄDLER take a look
World’s Fastest Write Speed for Embedded Memory
Authors: Tyler Neil
Published: January 2023

Researchers develop 128Mb STT-MRAM with world’s fastest write speed for embedded memory.
Robotics in Social Care
Authors: Tyler Neil
Published: January 2023

Among developed economies the problems associated with an ageing population are growing. Can robotics and autonomous systems help to ensure that the elderly have both active and fulfilling lives?
Modular Industry 4.0 Servers
Authors: Bergbauer Andreas , Hein Ansgar
Published: January 2023

Edge servers in Industry 4.0 environments are subject to very heterogeneous requirements, as Andreas Bergbauer and Ansgar Hein explain
Coming in Loud and Clear
Authors: Grylls Bethan
Published: January 2023

HEADPHONES COULD BE A THING OF THE PAST WITH A NEWLY DEVELOPED SYSTEM THAT CREATES SEPARATED AND MULTIPLE SOUND ZONES.
Next Generation Mid-Infrared Optical Sensor
Authors: Tyler Neil
Published: January 2023

CEA-Leti has developed a prototype next-generation optical chemical sensor using mid-infrared silicon photonics
Taking the Guesswork Out of Being Human
Authors: Lauwereins Rudy
Published: January 2023

Artificial intelligence is set to transform the way we live but we will need to add some creativity and wisdom to how it’s used and deployed, argues
Improving Reliability with Cryogenics
Authors: Tyler Neil
Published: January 2023

Cryogenics plays an increasingly important part in the development of electronics, but the components sold into this market need to be both incredibly reliable and well designed.
Designing with, not for Manufacturing
Authors: Grylls Bethan
Published: January 2023

A cloud-based platform looks to make collaboration between designers, suppliers and manufacturers easier.
Surface DNA
Authors: Grylls Bethan
Published: January 2023

The vehicles of the future must not only be able to “see”, but also “feel”.
System Success
Authors: Grylls Bethan
Published: January 2023

A new way of testing powertrain ECUs has led to reduced development times.
Cadence Unveils Clarity 3D Solver
Authors: Tyler Neil
Published: January 2023

Cadence enters the system analysis and design market.
Closing the Gap
Authors: Tyler Neil
Published: January 2023

Smart home technology has been promising much, for so long, but helped by new wireless standards and the use of voice technology is it now beginning to deliver?
Deploying Technology in Space
Authors: Tyler Neil
Published: January 2023

When used in space, electronic components have to contend with extreme conditions. What are the issues and solutions?
STEM Funding Gets a Boost
Authors: Tyler Neil
Published: January 2023

Northumbria University doubles the number of schools receiving science support.