bluuebunny/crossref_metadata_2025 huggingface dataset:
NCG-MHC-dKO mice - an excellent model for PBMC reconstitution and pharmacodynamic evaluation in the absence of GvHD
Authors: Chen Santi Suryani , Wang Huiyi , Xing Jun , Fan Jialu , Hou Huanhuan , Li Zhiying , Moore Mark , Zhao Jing , Xiang Gao , Ju Cunxiang
Published: August 2023

Human immune cell reconstitution (Peripheral Blood Mononuclear Cells; PBMC or CD34+ hematopoietic stem cell; HSC) is commonly performed in immunodeficient mouse strains, such as NCG, NSG, or NOG. Human immune reconstitution utilizing PBMCs is a much more rapid model, allowing for T-cell reconstitution within 2 weeks. Due to the occurrence of xenogeneic graft-versus-host disease (xGvHD) around 4 weeks post-engrafment, the application of PBMC-reconstituted NCG mice is relatively limited.

xGvHD is mainly induced by T cells derived from donor PBMC engraftment recognizing the murine host MHC class I and class II as foreign and attacking the host cells and organs. Deleting the β2m (NCG-β2m-KO) could reduce the occurrence of xGvHD; however, β2m is not only in the MHC class I subunit but also in the FcRn subunit, of which deletion shortens the half-life of IgG, making it unsuitable for IgG antibody agent evaluation. In addition, the deletion of MHC class I or class II alone results in an imbalanced CD4/CD8 ratio. To solve these problems, we developed the NCG-MHC-dKO mouse model by knocking out the H2K1, H2D1, and H2Ab1 genes. Compared with the existing NCG-B2m-KO mouse model, the NCG-MHC-dKO significantly prolonged survival, reduced xGvHD occurrence, and did not affect the CD4/CD8 ratio when reconstituted with PBMC. Furthermore, treatment with anti-PD-L1 antibodies significantly inhibited MDA-MB-231 tumor cell growth in PBMC-reconstituted NCG-MHC-dKO mice, similar to NCG mice. Based on our preliminary data, the NCG-MHC-dKO mouse is a promising model for evaluating antibody and cell therapy agents, assessing treatment-related cytokine release syndrome, and evaluating long-term toxicities of cell therapies.
Topical minoxidil reported hair discoloration: a cross-sectional study
Authors: Alhayaza Ghada , Hakami Alanoud , H. AlMarzouk Lenah , A. Al Qurashi Abddullah , Alghamdi Ghada , Alharithy Ruaa
Published: August 2023

Minoxidil is a widely utilized medication for various hair conditions, such as androgenic alopecia. The current literature lacks an original study that reports the possibility of this medication causing a well-noticed side effect, hair discoloration, among the treated patients. We conducted an observational study utilizing two face-validated questionnaires that experts, in dermatology, revised to assess the possibility of Minoxidil in inducing hair discoloration. This study was done in Saudi Arabia, and the data collection spanned October and November 2022. The first questionnaire was targeting the population, while the second was targeting practicing dermatologists. In survey 1, of 453 included patients, 56.7% of the participants were between the ages of 18-24, most of whom were females. Interestingly, 26% (n=118) noticed greying of hair and 14.8% (n=67) noticed other hair color changes. The hair discoloration was more prevalently noticed among the groups who used Minoxidil for a longer duration and among those with a family history of hair greying, with a p-value of 0.0001 for each group. Survey 2 was targeting dermatologists and was answered by 57 participants. Almost 60% of the physicians have ten years or more experience in Dermatology. 42.1% of the dermatologists noticed greying of hair on their patients after using Minoxidil. 17.5% of the physicians think Minoxidil caused hair greying. This observational study analyzed the data of more than 400 patients to assess the possibility of Minoxidil inducing hair discoloration; based on the data presented, we hypothesize that Minoxidil could be classified as a drug that potentially induces hair discoloration with more extended periods of usage and among those who have familial history of hair greying. Further confirmatory data are warranted to support such statement.
Flagellate dermatitis in a patient with testicular germ cell neoplasia on bleomycin
Authors: Mavridou Konstantina , Karakasi Aggeliki , Lampri Evangeli , Gaitanis George , Bassukas Ioannis D
Published: August 2023

Bleomycin, an antineoplastic antibiotic that inhibits DNA synthesis, is used to treat various malignant tumours such as Hodgkin's lymphoma, squamous cell carcinoma, and germ cell tumors. Flagellate erythema is a rare rash with a linear pattern that has been observed in association with bleomycin treatment. Herein, we present a 43-year-old patient with metastatic testicular cell neoplasms who developed a whiplash rash during treatment with a chemotherapy regimen that included bleomycin. A typical case of bleomycin-related flagellate dermatitis has been diagnosed and the main features of this characteristic adverse drug event are briefly discussed.
Cornual Pregnancy
Authors: Gaetani Maria , Di Gennaro Daniele , Vimercati Antonella , Vitagliano Amerigo , Dellino Miriam , Malvasi Antonio , Loizzi Vera , Pinto Vincenzo , Cicinelli Ettore , Di Naro Edoardo , Lacalandra Angelo , Damiani Gianluca Raffaello
Published: August 2023

Cornual pregnancy (CP) is a subtype of ectopic pregnancy that is implanted in the interstitial segment of the fallopian tube which is defined as the tubal section crossing uterine muscular tissue. Widely recognized risk factors for CP are endometriosis, uterine leiomyomata, or pelvic inflammatory disease; all these diseases can cause tubal anatomic changes and consequently alter embryo physiological implant process. Many treatment options are available for this condition each one must be tailored according to patient and operating scenario. The incidence of uterine ruptures in the scarred uterus appears to be low, but the fear of it remains and therefore medical treatment might be favored over cornual wedge resection. The actual risk of uterine rupture after medical treatment is unknown. Multiple testing strategies exist to diagnose CP, but caution needs to be used to avoid a false diagnosis.
The Effectiveness of Combined Local and Systemic Methotrexate Treatment in Cesarean Scar Pregnancy Weeks 8 to 14
Authors: Van Xuyen , Bui Thuong , Dinh Hoang The , Van Thong , Tran Anh
Published: August 2023

Objectives:

This study aims to identify the success rate and correlated factors of combined local and systemic methotrexate (MTX) injection treatment in cesarean scar pregnancy (CSP).

Materials and Methods:

The combined local and systemic MTX administration has been used for CSP weeks 8–14 at Tu Du Maternal Hospital; however, its effectiveness and correlated factors have not been closely investigated. This is a retrospective case series of 123 CSP patients between 8 and 14 weeks of gestation who were treated at Tu Du Hospital from the year 2016 to 2020.

Results:

The success rate, uterine-sparing rate, and side effects of MTX treatment are 50.4%, 95%, and 17.2%, respectively. The factors related to treatment failure with statistical significance included gestational age (odds ratio [OR] = 3.99), residual myometrial thickness >3 mm (OR = 0.37), and postprocedure gestational sac diameter (OR = 1.09).

Conclusion:

Combined local and systemic MTX injection is minimally invasive and effective in CSP weeks 8–14. Therefore, it should be utilized routinely.
Trichotillomania in Children − How can a Dermatologist Deal with it?
Authors: Thakkar Sejal , Desai Nimisha
Published: August 2023

Hair loss in children is an important cosmetic concern, especially in adolescents where body image matters. Trichotillomania manifests through patchy hair loss which reflects underlying psychiatric conditions. It is a challenge for the dermatologist, who are first contact physicians, to deal with such cases who are secretly struggling with their inner turmoil. Hence, they must be well versed to deal with such patients. The current review aims to facilitate the dermatologist to handle them effectively. We performed PubMed and Google Scholar searches of English literature using the terms “Trichotillomania”, “Trichotillosis,” “Trichotillomania in Children,” “Trichotillomania in pediatrics,” “Trichotillomania in adolescents,” “Hair pulling disorder,” “Obsessive-Compulsive disorders AND Dermatology,” “Psychodermatology,” and “Psychocutaneous disorders.” The selected publications were reviewed for additional resources. Thorough psychological evaluation of the patient along with the cutaneous examination will help the dermatologists in establishing the diagnosis. Dermatologists should be empowered regarding the need of mental health referral and should be able to convey the same to the patient/family members empathetically. They can offer habit reversal therapy, mainstay treatment, as well as pharmacotherapy as and when needed after adequate training.
Carbon Baby Syndrome: An Unusual Cause of Progressive Generalized Melanosis
Authors: Bindagi Anisha P. , Srinivas Sahana M.
Published: August 2023

Universal acquired melanosis, also referred to as Carbon baby syndrome, is a rare cause of progressive generalized hyperpigmentation of skin and mucosa. We describe a case of a 2-year-old boy with diffuse darkening of skin and mucosa for 3 months of age. Histopathology revealed increased melanin in the basal and suprabasal layers of the epidermis.
Association of heavy metals and trace elements in carcinoma urinary bladder: A case-controlled study
Authors: Panaiyadiyan Sridhar , Quadri Javed Ahsan , Nayak Brusabhanu , Pandit Surabhi , Singh Prabhjot , Sachan Ankit , Kaushal Seema , Sarwar Saba , Seth Amlesh , Shariff Ahmadullah
Published: August 2023

Introduction:

Abnormal levels of heavy metals (HM) and trace elements (TE) affect body metabolism and can induce carcinogenesis. This study aims to evaluate the role of HM and TE in carcinoma urinary bladder (CAUB).

Methods:

Patients with biopsy-proven CAUB (n = 100) were taken as the study group, while age-and sex-matched healthy volunteers were taken as control (n = 100). Blood and urine samples were compared for Arsenic (As), Copper (Cu), Manganese (Mn), Selenium (Se), Cadmium (Cd), Lead (Pb), and Mercury (Hg) levels. Serum glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and lipid peroxidation (LPO) levels were assessed to know the redox status between the two groups.

Results:

A significantly higher blood level of As, Mn, and Pb was observed in CAUB cases as compared to controls. Blood Se level was significantly lower in CAUB patients. On comparing urinary levels, CAUB patients had a higher As, Mn, and Pb levels compared to controls. Further, 68% and 59% of patients had their blood and urinary HM and TE levels above the permitted level, respectively. CAUB cases also had a lower GSH-Px (113.5 ± 44.7 vs. 163.9 ± 120.5, P = 0.0002), lower SOD levels (11.35 ± 5.6 vs. 13.75 ± 3.9, P = 0.008), and a higher LPO levels (15.5 ± 14.7 vs. 11.18 ± 11.2, P = 0.02) in the serum.

Conclusions:

A significantly higher concentration of As, Mn, and Pb was noted in the blood and urine of CAUB patients compared to controls. CAUB cases also had lower serum GSH-Px and SOD levels with a concomitant increased serum LPO assay suggesting underlying oxidative stress.
Comparison of outcomes after open versus robotic kidney transplantation: A systematic review and meta-analysis
Authors: Madhavan Kumar , Jena Rahul , Bhargava Priyank , Pradhan Aditya , Bhandari Mahendra
Published: August 2023

Introduction:

This meta-analysis compares the clinical outcomes of robot-assisted kidney transplant (RAKT) to open kidney transplant (OKT).

Methods:

A systematic search of Scopus and MEDLINE databases was carried out using a combination of keywords to identify studies comparing RAKT to OKT. Baseline characteristics and preoperative and postoperative data were collected along with data on the short- and long-term outcomes. The study was registered in PROSPERO and Assessing the Methodological Quality of Systematic Reviews and Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were followed.

Results:

A total of 16 studies were included with a total of 2555 patients, of which 677 underwent RAKT and 1878 underwent OKT. This meta-analysis shows a significant benefit of RAKT over OKT in terms of less intra-operative blood loss, smaller incision length, less postoperative pain scores at 24 and 48 hours, and a lower incidence of surgical site infections (SSIs), especially in obese patients. In addition, the incidence of postoperative lymphoceles was lower in the RAKT group compared to the OKT group, although not statistically significant. There was no difference between the two groups in terms of short-term graft functional outcomes and overall survival. The number of deceased donor recipients undergoing RAKT was very small. At the time of reporting this meta-analysis, no randomized controlled trials (RCTs) had been published.

Conclusion:

This meta-analysis showed that RAKT is a safe and feasible alternative to OKT, especially in obese individuals. Further trials are needed to confirm the safety, efficacy, and cost-effectiveness of RAKT.
Rare case of post-vertebroplasty fungal spondylodiscitis: Case report
Authors: K C Avinash , Mehta Satyen
Published: August 2023

Vertebroplasty is a commonly done procedure in osteoporotic compression fracture. Cement leakage is the most common complication associated with vertebroplasty. Infection following vertebroplasty is rare. Fungal spondylodiscitis following vertebroplasty has not been reported in the literature. The objective of this clinical case report was to highlight this rare fungal spondylodiscitis following vertebroplasty. A 67-year-old woman was diagnosed with osteoporotic compression fracture for which vertebroplasty was done. During the procedure, the primary surgeon noticed the cement leakage without any neurological complication. The patient was referred to us. The patient was diagnosed with spondylodiscitis with cement leakage. We performed an open biopsy with cement removal with posterior thoracic decompression and interbody fusion. On microbiological examination, Aspergillus fumigatus were isolated from multiple samples that were susceptible to voriconazole. On 1-month follow-up, patient’s pain significantly reduced with normalized inflammatory markers. Presence of immunocompromised status with diabetes mellitus and lack of quality operating theater with inadequate maintenance of sterility protocols during the procedure could be the reason for the infection.
Multiple sporadic spinal hemangioblastoma at the filum terminale and cervicodorsal junction: A case report and review of literature
Authors: Gurjar Hitesh , Gaonkar Vibha , Bansal Tungish , Borkar Sachin
Published: August 2023

Hemangioblastomas are low-grade tumors that frequently occur in the posterior fossa. Only 1%–5% of these tumors occur in the spinal cord and there are a handful of cases of filum terminale hemangioblastomas described in the literature. Here, we present a case with two spinal hemangioblastomas at filum terminale and cervicodorsal junction of sporadic origin. A 28-year-old woman presented with low back pain radiating to right lower limb with weakness of both lower limbs and urinary incontinence. The findings of the examination revealed asymmetric quadriparesis with more weakness on the left side of the body. Magnetic resonance imaging revealed a cervicodorsal and lumbar T2 hyperintense lesion with flow voids. Imaging findings were suggestive of hemangioblastoma. En bloc excision of both the tumors was performed and the diagnosis was confirmed on histopathology. She had an uneventful postoperative course and complete neurological recovery at the final follow-up. Multiple sporadic spinal hemangioblastomas involving the filum terminale are a very rare entity. Complete surgical excision provides good relief of symptoms.
A rare case of priapism secondary to intervertebral disc prolapse: Case report and literature review
Authors: Sheth Sharvin K , Jhala Amit C
Published: August 2023

Lumbar canal stenosis (LCS) is characterized by narrowing of the central spinal canal or lateral recesses and foramina, leading to compression of nerve tissues. It causes neurogenic claudication, which manifests as back pain and variety of lower limb symptoms such as pain, tingling/numbness, or paresthesia on ambulation. A rare symptom of LCS is priapism, which is thought to occur due to parasympathetic dysfunction. We describe a case of a 45-year-old man, who presented with neurogenic claudication and intermittent priapism due to lumbar intervertebral disc prolapse, which resolved completely after surgical decompression, and literature review for the same.
Idiopathic spinal cord herniation—An extremely rare cause of paraparesis: Case report
Authors: De Smet Bernardo , Pinheiro Teresa , Fonseca Lino
Published: August 2023

Idiopathic spinal cord herniation is a rare disorder, consisting of a ventral displacement of the spinal cord through a dural defect. The resulting adhesion and vascular compromise lead to neurological impairment. We report the case of a 54-year-old male, with a previous urological surgery resulting in chronic vesical catheterization, with a worsening paraparesis associated with anesthesia below T10. The magnetic resonance imaging showed a ventral displacement of the spinal cord at T7/T8 with an enlarged posterior subarachnoid space at that level. A four-level laminotomy was performed followed by spinal cord herniation reduction and closure of the anterior dural defect with a dural replacement. The patient had a partial recovery of his motor deficits regaining his ability to walk with the support of a single crutch. The purpose of this study was to highlight the existence of this extremely rare cause of paraparesis, which is often misdiagnosed.
Postoperative Outcomes Following Surgical Stabilization of Rib Fractures Stratified by 5-Factor Modified Frailty Index
Authors: Saraswat Nirvana , Werwie Nicole , Wu Jin , Hery Danielle , Saunders Emily , Bundy Hannah , Elliott John O. , Goslin Brent , DeVoe William
Published: August 2023

Objectives:

Surgical stabilization of rib fractures (SSRF) improves outcomes in patients with flail chest and displaced fractures with impaired pulmonary function. Elderly and frail patients with such injuries are at risk for significant morbidity and may benefit from SSRF. The 5-factor modified frailty index (mFI-5) is a validated predictor of postoperative outcomes. The purpose of this study is to evaluate the relationship between frailty and outcomes following SSRF at a tertiary care trauma center.

Methods:

A retrospective review of patients undergoing SSRF from 2015 to 2019. Patients over 18 years old with two or more displaced fractures were included in the study. Exclusion criteria were isolated fracture, traumatic brain injury, and pulmonary contusion. Frail patients were defined by an mFI-5 score 2 or greater. Chi-square analysis, Fischer's exact test, and Student's t-test were used for comparative analysis as appropriate. P < 0.05 was considered statistically significant.

Results:

One hundred and fifty-four patients met inclusion criteria. Forty-eight patients were designated frail and 106 nonfrail. The mean number of fractures was similar between frail and nonfrail groups (7.0 vs. 7.3, P = 0.685). Injury Severity Score was lower in the frail group (14.5 vs. 17.8, P = 0.02). Inpatient mortality (P = 0.312), rates of pneumonia, end-organ dysfunction, and surgical site infections were similar (P > 0.05). Intensive care unit admission (47.9% vs. 29.2%, P = 0.025) and tracheostomy rates (P = 0.009) were increased in the frail group. Frailty also increased the risk of prolonged mechanical ventilation >48 h on multivariate analysis.

Conclusion:

Frail patients, stratified using mFI 5 score, experienced similar rates of multiple postoperative outcomes, including mortality, but had increased rates of prolonged ventilation and tracheostomy. Despite observed but expected increased morbidity in these patients, the similar complication and mortality rates suggest a role for surgical stabilization of severe rib fractures in frail patients.
Prevalence and Correlates of Peripheral Neuropathy amongst Type 2 Diabetes Mellitus Patients – A Community-Based Epidemiological Study in a Town of Eastern India
Authors: Chakraborty Sumanta , Majumder Anirban
Published: August 2023

Background:

Diabetic peripheral neuropathy (DPN) is a microvascular complication of type 2 diabetes mellitus (T2DM) which may be attributed to chronic uncontrolled hyperglycaemia. DPN increases the risk of foot ulcers and non traumatic amputations, leading to disability, morbidity and poor quality of life for the diabetics.

Aims:

This study aims to find out the prevalence of peripheral neuropathy amongst T2DM patients and ascertain the correlates for the same. Settings and Design: A cross sectional study was conducted amongst 104 diabetic individuals of Bankura city of West Bengal using principles of simple random sampling technique.

Materials and Methods:

Data on peripheral neuropathy were collected using Michigan Neuropathy Screening Instrument and correlates were assessed by a pre designed pre tested schedule consisting of background and socio demographic characteristics along with medication adherence rating scale.

Statistical Analysis Used:

Data were entered into Excel (Microsoft Inc.) and all calculations were done using IBM Statistical Package for the Social Sciences (SPSS) (Version 20.0, IBM). Data were analysed and presented using principles of descriptive and analytical statistics.

Results:

The prevalence of DPN was 59.1%. The presence of co morbidities, poor socio economic status, polypharmacy, food insecurity, catastrophic health expenditure and lack of social insurance were found significantly associated with DPN.

Conclusions:

DPN prevalence was found to be considerably high. Multiple factors were found to culminate it, upon which socio economic and health care affordability issues were prominent. A multi disciplinary approach focusing on them using Patients oriented evidence that matters approach, diabetes education and periodic screening of the diabetic population may help in mitigating the morbidity risks.
The Structural Profile of HPV 18 in Terms of Chromosomal and Nuclear Degenerative Changes and the Ratio of Nucleus/Cytoplasm on Liquid based Cervical Cells
Authors: Oz Zehra Safi , Barut Figen , Kokturk Furuzan , Gun Banu Dogan
Published: August 2023

Background:

HPV 18 is one of the important oncogenic types. HPV 18 is generally evaluated together with HPV 16 and/or high-risk HPV types in light microscopic studies. The purpose of this study was to evaluate the impact of only HPV 18 on the nucleus/cytoplasm ratio, and chromosomal and nuclear degenerative changes in liquid-based samples.

Materials and Methods:

Eighty liquid-based cervical samples were used in this retrospective study. These smears were prepared by HPV Deoxyribonucleic Acid (DNA) detection and genotyping with the Cobas 4800 HPV system. Forty HPV 18 infected and forty smears with no infection agent were evaluated for chromosomal (nuclear budding, micronuclei), nuclear degenerative changes (membrane irregularity, nuclear enlargement, hyperchromasia, abnormal chromatin distribution, binucleation (BN), karyorrhexis (KR), karyolysis (KL), karyopyknosis (KP)), and cytologic findings (koilocyte (KC), cells with perinuclear PR) using light microscopy. Cellular diameters were evaluated using image analysis software. Statistical analysis was performed with Statistical Package for Social Sciences (SPSS) 19.0. p values < .05 were considered significant.

Results:

The statistically significant difference between the presence of HPV 18 and karyorrectic cell, KC, nuclear membrane irregularity, enlargement, the mean nuclear width and height (p < 0.05). No cellular changes other than those mentioned were observed.

Conclusions:

The present study is significant in that, it reveals the relationship between only and particularly HPV 18 and nucleus/cytoplasm ratio, and chromosomal and nuclear degenerative changes in liquid-based cytology. HPV 18 affects KR, koilocytosis, nuclear membrane irregularity, enlargement, and nuclear diameters. Light microscopic analysis of these abnormalities increases the sensitivity and specificity of cytology in the evaluation of cellular pictures due to HPV 18.
Vonoprazan-amoxicillin dual therapy for Helicobacter pylori eradication: A systematic review and meta-analysis of randomized controlled trials
Authors: Zhou Ben-Gang , Mei Yu-Zhou , Jiang Xin , Zheng Ai-Jing , Ding Yan-Bing
Published: August 2023

Background:

Vonoprazan-amoxicillin (VA) dual therapy has recently been proposed to eradicate Helicobacter pylori (H. pylori) with controversial results. We, therefore, conducted a meta-analysis to assess the effect of this therapy for H. pylori eradication.

Methods:

We searched PubMed, Embase, Cochrane Library, and Web of Science database from inception until November 2022, collecting randomized controlled trials (RCTs) comparing VA dual therapy with other regimens for H. pylori eradication. Pooled relative risks (RRs) were calculated using random effects model.

Results:

Five RCTs were ultimately included. Compared with the vonoprazan-amoxicillin-clarithromycin (VAC) triple therapy, the eradication rate of VA dual therapy was lower in intention-to-treat (ITT) analysis (n = 3 RCTs, RR = 0.94, 95% CI: 0.88–0.99, P = 0.03), but there was no significant difference between them in the per-protocol (PP) analysis (RR = 0.96, 95% CI: 0.91–1.01, P = 0.11). For clarithromycin-resistant H. pylori strains, the eradication rate of VA dual therapy was significantly higher than that of the VAC triple therapy (n = 2 RCTs, RR = 1.20, 95% CI: 1.03–1.39, P = 0.02). Compared with the PPI-based triple therapy (PAC), VA dual therapy had a superior eradication rate (n = 2 RCTs, ITT analysis RR = 1.13, 95% CI: 1.04–1.23, P = 0.003; PP analysis pooled RR = 1.14, 95% CI: 1.06–1.22, P = 0.0004). Compared with VAC or PAC triple therapy, VA dual therapy has a similar incidence of total adverse events and compliance.

Conclusions:

VA dual therapy had a similar effect compared to VAC triple therapy and was superior to PAC triple therapy. Future RCTs are needed to ascertain the optimal dosage and duration of vonoprazan and amoxicillin, and the effect of VA dual therapy compared with the mainstream regimens recommended by current guidelines.
Property (T) in density-type models of random groups
Authors: Ashcroft Calum James
Published: August 2023

We study property (T) in the

\Gamma(n,k,d)

model of random groups: as

k

tends to infinity this gives the Gromov density model, introduced in 1993. We provide bounds for property (T) in the

k

-angular model of random groups, i.e., the

\Gamma (n,k,d)

model, where

k

is fixed and

n

tends to infinity. We also prove that for

d>1/ 3

, a random group in the

\Gamma(n,k,d)

model has property (T) with probability tending to

1

as

k

tends to infinity, strengthening the results of Żuk and Kotowski–Kotowski, who consider only groups in the

\Gamma (n,3k,d)

model.
Konserwatyzm i nowoczesność w edukacji. Dwoistość – otwarcie – pułapki
Authors: Sajdak-Burska Anna
Published: August 2023

W artykule przedstawione zostały metodologiczne aspekty pozwalające na zbudowanie rusztowania kategorialnego dla projektu „nowoczesna szkoła konserwatywna”. Autorka głębiej przygląda się metodologicznym i semantycznym argumentom pozwalającym zbliżyć do siebie konserwatyzm i nowoczesną dydaktykę. Kluczem otwierającym tę możliwość czyni opisaną przez Lecha Witkowskiego kategorię dwoistości. Zastosowanie tej kategorii pozwoliło na przedefiniowanie versus używanego w opozycji „konserwatyzm versus nowoczesne kształcenie”. Autorka opisuje możliwości otwarcia obu stanowisk – konserwatyzmu i nowoczesności – na siebie. Wejście w dialog, znalezienie pola wspólnego nie wygasza różnic. Te pozostają, a z nich wyprowadzane są siły dośrodkowe i odśrodkowe, powodujące napięcie i drganie całego pola. Kategoria dwoistości, ambiwalencji podkreśla to napięcie i ruch oscylacyjny. Ruch pomiędzy jednym a drugim biegunem naraża całość na pułapki magnetycznego przyciągnięcia przez któryś z biegunów, co może się wyrażać gwałtownym skrętem ku fundamentalnym elementom jednego ze stanowisk. Artykuł kończy przedstawienie pułapek, na które narażona jest nowoczesna szkoła konserwatywna, kryjących się w fundamentalizmie konserwatyzmu oraz dydaktyce krytycznej.

Conservatism and Modernity in Education: Duality – Openness – Pitfalls: The article presents methodological aspects that allow building a categorical scaffolding for the “modern conservative school” project. The author takes a deeper look at the methodological and semantic arguments that make it possible to bring “conservatism” and “modern didactics” closer together. She makes the category of “duality” described by Lech Witkowski the key that opens up these possibilities. The use of the category of “duality” made it possible to redefine versus used in the opposition “conservatism versus modern education.” The author describes the possibilities of opening both positions – conservatism and modernity – towards each other. Entering into dialogue, finding a field of common ground does not extinguish differences. These remain, and from them centripetal and centrifugal forces are derived, causing tension and vibration in the entire field. The category of duality, ambivalence emphasizes this tension and oscillatory movement. The movement between one pole and the other exposes the whole to the pitfalls of magnetic attraction by either pole, which can express itself in a sharp turn toward the fundamental elements of either position. The article concludes with a presentation of the pitfalls to which the “modern conservative school” is exposed, which are hidden in the fundamentalism of conservatism and critical didactics.
Przebić się – postulat (nowej) strategii lekturowej. Czytając propedeutycznie Lecha Witkowskiego Uroszczenia i transaktualność w humanistyce
Authors: Maliszewski Krzysztof
Published: August 2023

Tekst stanowi autorskie wprowadzenie do lektury książki Lecha Witkowskiego Uroszczenia i transaktualność w humanistyce. Florian Znaniecki: dziedzictwo idei i jego pęknięcia (Kraków: Oficyna Wydawnicza Impuls, 2022). Książka ta jest odczytywana z użyciem ramy interpretacyjnej skonstruowanej na bazie kategorii przebijania się. Chodzi o przedzieranie się przez blokady recepcyjne, które uniemożliwiają wartościowy i możliwie pełny kontakt z dziełem klasyka w kulturze symbolicznej. Przeszkody w recepcji dokonań Floriana Znanieckiego, które są tu brane pod uwagę, to: rozległość i skomplikowanie dorobku, pomniejszające strategie lekturowe, słabe punkty badanej myśli, przesłony społeczno-historyczne, bariery współczesnych praktyk akademickich, puste miejsca dyscyplinarne, wyobrażenia o dziele jako całości w znaczeniu sfinalizowanej i przez to zamkniętej przeszłości. Ostatecznie książka Witkowskiego jest prezentowana jako zaproszenie do teoretycznej – a nie na przykład biograficznej – lektury dzieła Znanieckiego, stawiające zaproszonych w kłopotliwym, ale ożywczym położeniu.

To Break Through – The Postulate of a (New) Reading Strategy: While Reading Propaedeuticly of Lech Witkowski’s Uroszczenia i transaktualność w humanistyce: The text is an original introduction to Lech Witkowski’s book Uroszczenia i transaktualność w humanistyce. Florian Znaniecki: dziedzictwo idei i jego pęknięcia (Kraków: Oficyna Wydawnicza Impuls, 2022). This book is read using an interpretative framework constructed based on the category of breaking through. It is about breaking through the reception blocks that prevent valuable and possibly full contact with the work of the classic in symbolic culture. Obstacles to the reception of Florian Znaniecki’s achievements, which are taken into account here, include: the extensiveness and complexity of his output, reading strategies that diminish its object, weak points of the studied thought, socio-historical veils, barriers of contemporary academic practices, empty spaces in scientific disciplines, ideas about the work as a totality in the meaning of a finalized and thus closed past. Ultimately, Witkowski’s book is presented as an invitation to a theoretical – and not, for example, biographical – reading of Znaniecki’s work, which puts the invited readers in an embarrassing but invigorating position.
Normal Servikal Sitolojili Kadınlarda High Risk Human Papillomavirus Sıklığı ve Tip 16/18 Dağılımı: Tek Merkez Çalışma
Authors: ŞENELDİR Hatice , GÜMÜŞTAŞ Beyda , GÜNHAN Gülsüm , KILLI Feride Ebrar , OZAN Berivan , CANBAŞ İsmail , SEVİNDİ Deryagül
Published: August 2023

Amaç

Serviks kanseri, kadınlarda en yaygın görülen kanser türlerinden biridir. Serviks kanserinin Human Papilloma virüs (HPV) ile ilişkisi kanıtlanmış olup hastaların tamamına yakınında HPVDNA varlığı gösterilmiştir.

Çalışmadaki amacımız; normal servikal sitolojili kadınlarda yaşlara göre high risk HPV (hrHPV) sıklığını ve tip 16/18 dağılımını araştırmak ve diğer çalışmalarla karşılaştırmasını yapmaktır.

Araçlar ve Yöntem

Çalışmamızda İstanbul Medeniyet Üniversitesi Prof. Dr. Süleyman Yalçın Şehir Hastanesi Tıbbi Patoloji Anabilim Dalı’nda 01.10.2018-01.10.2020 tarihleri arasında, servikal sitolojisi malignite açısından negatif ve hrHPV DNA incelemesi yapılmış 4212 servikal sitolojik materyal retrospektif olarak değerlendirildi.

Olgular, yaşlarına göre 21-24 yaş, 25-29 yaş, 30-45 yaş, 45-54 ve 55-65 yaş olmak üzere 5 gruba ayrıldı. Gruplar hrHPV pozitifliği ve tip 16/18 dağılımı açısından analiz edildi.

Bulgular

Toplam 4212 olgunun 494’ünde (%11.73) hrHPV pozitifliği saptandı. Grup 1 (21-24yaş), grup 2 (25-29 yaş), grup 3 (30-45 yaş), grup 4 (45-54 yaş) ve grup 5 (55-65 yaş) hrHPV pozitiflik oranı sırası ile %31.97, %16.83, %18.34, %11.29, %8.73 ve % 10.18 olarak bulundu.

HrHPV pozitifliği açısından Grup 1 ve 2 ile diğer gruplar arasında istatistiksel olarak anlamlı farklılık bulunmaktadır (p
THE LATEST TRENDS IN GEORGIA’S BUSINESS REGISTER
Authors: Dzebisauri Lia , Mindorashvili Marine (Maia)
Published: August 2023

Lia Dzebisauri i

E-mail: lia.dzebisauri@tsu.ge

Associate Professor, Ivane Javakhishvili Tbilisi State University

Tbilisi, Georgia

https://orcid.org/0009-0002-2604-9323

 

Marine (Maia) Mindorashvili 

E-mail: maia.mindorashvili@tsu.ge

Associate Professor, Ivane Javakhishvili Tbilisi State University

Tbilisi, Georgia

https://orcid.org/0009-0001-7177-9870

Abstract .In this paper, we examine the Statistical Business Register (SBR) in Georgia, which serves as the foundation for economic statistics. To keep up with the demands of the modern digital economy, the SBR requires ongoing capacity-building efforts. It's a critical component in generating official statistics that inform evidence-based decision-making. In light of the ongoing globalization process, particularly in the wake of the COVID-19 pandemic, there's a growing demand for high-quality, comparable SBR and economic statistics at the international level. Geostat's BR is unique in that it allows for determining an entity's activity status. However, the current globalization process presents a challenge to creating a perfect SBR, increasing the need for an internationally comparable SBR in the post-COVID-19 pandemic world. Our paper highlights the significance of the SBR and investigates registered and active business entities in Georgia according to various parameters, such as economic activities, legal status, and territorial distribution by regions, and statistical trends of active companies during pre and pandemic periods. We also identify areas where COVID-19 had the most detrimental effect and where further recovery is necessary for the sustainable development of Georgia's economy. As the backbone for economic statistics, the SBR needs continued capacity-building activities in the modern digital economy. It plays a central role in producing official statistics, both in terms of how the statistics are produced and the quality of the statistics that draw on information from them. Our article, in particular, is devoted to improving the quality and modernizing the indicators of the statistical business register, which further contributes to producing high level business and macroeconomic statistics.
MODERN STATISTICAL TRENDS OF EXPORTS BY SEA TRANSPORT TO THE CIS COUNTRIES
Authors: Abesadze Nino , Abesadze Otar , Paresashvili Nino
Published: August 2023

Nino Abesadze

Email:nino.abesadze@tsu.ge

Associate Professor, Ivane Javakhishvili Tbilisis State University

Tbilisi, Georgia

https://orcid.org/0000-0002-6564-2771

 

Otar Abesadze

Email:o.abesadze@gmail.com 

Associate Professor, Georgian National University SEU

Tbilisi, Georgia

https://orcid.org/0000-0003-1644-4995

 

Nino Paresashvili

Email:nino.paresashvili@tsu.ge 

Associate Professor, Ivane Javakhishvili Tbilisis State University

Tbilisi, Georgia

https://orcid.org/0000-0001-7645-6491

Abstract. In the modern conditions of globalization, the use of sea transport is becoming more and more popular, the share of which is quite high in export trade relations.

The main goal of the paper is to outline the trends in export under the conditions of sea transport and to determine the main parameters. Analysis, synthesis, induction, deduction were used in the research process, as well as specific   statistical    methods:   observation,   grouping,  and analysis. For   the   purpose of analysis, data were processed, and indicators   were   calculated    with computer software SPSS.

Over the years, historically, the CIS has been and still is one of the major trade partners of Georgia. Its share in the total volume of exports is almost 50%, which was characterized by certain fluctuations in 2016-2022. If at the beginning of the period, only 35% of Georgia's total exports went to CIS countries, by 2019 its share increased to 53.8%.

Export relations with the CIS are mainly carried out by road (81%), while marine transport has a share of 9.8%. In 2016-2022, the average annual growth rate of exports to the CIS countries amounted to 123.9%, while the increase of exports by sea transport was 19% annually during the same period. In 2022, the share of exports by sea transport decreased, which makes up 4.7% of the total export in the CIS countries, which is 5.9 percentage points lower than the previous year's figure. Despite the fact that before and after the pandemic, Georgia has active trade relations with the countries of the region, bat a large part of re-exports, 94%, goes to the CIS countries, by road and then by sea.

Georgia's total export to the CIS increased by 33.3% compared to the previous year, while local export decreased by 1%. The increase in exports to the CIS was largely related to the increase in re-exports because in this period re-exports increased by 76%. Despite the growth of domestic exports, re-exports have a significant share in the total exports of Georgia with the CIS, and its change affects the characteristics of foreign trade. Accordingly, the ratio between local export and re-export is variable, which amounted to 0.69 in 2022.
A STUDY OF TEACHERS' INVOLVEMENT IN THE SEXUAL EDUCATION PROCESS
Authors: Katamadze Davit , Meskhidze Shorena , Rusieshvili Nino
Published: August 2023

Davit Katamadze

Email:datoqatamadze@gmail.com

Doctor of Social Sciences (Psychology), BSU, Teacher of the Department of Psychology

Batumi, Georgia

https://orcid.org/0009-0008-8815-1167

 

Shorena Meskhidze

Email:shorena.meskhidze@bsu.edu.ge 

PhD candidate in psychology, BSU Assistant

Batumi, Georgia

https://orcid.org/0000-0001-9801-5347

 

Nino Rusieshvili 

Email:niniarusieshvili@gmail.com 

Teacher, Master of Clinical Psychology, BSU, special teacher of psychology clinic

Batumi, Georgia

https://orcid.org/0009-0002-6370-5553

Abstract. Sexuality education is a combination of high-quality teaching methods that not only covers the medical aspects of sexuality, but also focuses on human sexuality, personal relationships, developmental psychological features, anatomy, sexually transmitted diseases, intercourse, sexual orientation, gender identity, contraception, and sexual If around reproductive rights and responsibilities. The purpose of sexual education is to equip young people with the necessary information and values so that they can develop the ability to have safe and perfect sexual relations, which takes into account the pleasure factors as well as the formation of a sense of responsibility for their own sexual and reproductive health and well-being.

Best practice in sexual health education focuses on the importance of the role of teachers and ensuring they are well prepared. One of the most critical factors affecting the effectiveness of sexuality education programs is the comfort and skill of the teacher. Teachers should be well prepared to introduce students to the basic principles of sexuality education, freely and without any hindrance factors.

The purpose of our research was to study how much the teachers working in the general education space are informed about the sexual education program, as well as how they see their own role in the preparation and implementation of the sexual education program. Our goal was also, if necessary, to hold an informational meeting for them and introduce them to the sexual education program. According to our hypothesis, teachers see the need to implement a sex education program, although they are not ready to talk about sex education issues.

The results of the study confirmed our assumption. In particular, it was revealed that teachers do not consider themselves competent to talk about issues related to sexuality education. However, 48% of teachers would like to talk about these issues. Most teachers place responsibility on parents.

It is worth noting the fact that most of the teachers express their desire to be retrained on issues of sexual education.
RESEARCH OF PROFESSIONAL ORIENTATIONS AMONG HIGH SCHOOL PUPILS
Authors: Beridze Ketevan , Meskhidze Shorena , Ketchakmadze Rusudan , Beridze Rusudan , Varshanidze Eteri
Published: August 2023

Ketevan Beridze

Email:k.beridze@bsu.edu.ge

Associate Professor, Batumi Shota Rustaveli State University

Batumi, Georgia

https://orcid.org/0000-0001-6268-7037

 

Shorena Meskhidze

Email:shorena.meskhidze@bsu.edu.ge 

Batumi Shota Rustaveli State University, Assistant

Batumi, Georgia

https://orcid.org/0000-0001-9801-5347

 

Rusudan Ketchakmadze

Email:r.kechakmadze@bsu.edu.ge 

Associate Professor, Batumi Shota Rustaveli State University

Batumi, Georgia

https://orcid.org/0000-0003-1046-7264

 

Rusudan Beridze 

Email:r.beridze@bsu.edu.ge 

Associate Professor, Batumi Shota Rustaveli State University

Batumi, Georgia

https://orcid.org/0000-0001-5374-2815

 

Eteri Varshanidze

Email:eteri.varshanize@bsu.edu.ge 

Batumi Shota Rustaveli State University, Assistant

Batumi, Georgia

https://orcid.org/0000-0002-4779-2733

Abstract. The choice of a profession is one of the important stages in a person's life, it can be said that it determines most of the future life. The choice of profession is, first of all, the choice of a person. When choosing a profession, a person chooses not only the necessary means to meet material needs, but also a way of life. A choice made without regard to the profession, or only taking into account external circumstances or the interests of others, is an experiment that can cost a person and the people around him dearly.

            The purpose of our study was to study the professional interests and professional orientation of the students of the pilot schools, to determine how well they are informed about the issues of vocational education and what factors influence the choice of a profession. We should also conduct a training on the topic: "Choose a profession." According to the hypothesis, the students of our school are less informed about the issues of vocation, and are also insufficiently prepared for the right choice of profession.

            The results of the study confirmed our assumption. In particular, it was found that the students of our school are less informed in matters of vocational training, and are also insufficiently prepared for the right choice of profession, which means taking into account their own interests, skills and abilities when choosing a profession. Pupils experience a lack of information on issues related to professions.

            In addition, respondents believe that the school needs the work of a psychologist who will provide qualified advice on issues related to the choice of profession.

It is noteworthy that it is important that pupils are better informed about what skills and abilities are necessary for mastering different professions. Therefore, at each stage of the study, it was important to determine the correspondence of skills and abilities to the chosen profession.
PROBLEMS OF ENSURING BUDGETARY SECURITY OF THE STATE DURING MARTIAL LAW
Authors: Sidelnykova Larysa , Posadnieva Oksana
Published: August 2023

Larysa Sidelnykova

Email:larisa1907s@gmail.com

Doctor of Economics, Professor Kherson National Technical University

Khmelnytskyi, Ukraine

https://orcid.org/0000-0001-7182-2923

Oksana Posadnieva

Email:posadnevaoksana@gmail.com

PhD in Economics, Associate Professor Kherson National Technical University

Khmelnytskyi, Ukraine

https://orcid.org/0000-0001-8721-5124

 

Abstract. The article examines the assessment of the budgetary security of the state in periods of macroeconomic shocks. The balance of the State Budget of Ukraine over the past 10 years is analyzed. A chronic deficit of the state budget are revealed. The main reasons for the budget deficit are given. It is noted that the chronic budget deficit is the main destructive factor that leads to a decrease in budget security. The place of budgetary security in the general economic security of the state is shown. The main indicators that characterize the level of budgetary security of the state are described. Special attention is paid to indicators that depend on the level of budget balance. The main reasons for the growth of the deficit during the previous destructive events in the Ukrainian economy and the factors that contributed to the growth of the deficit during the Russian-Ukrainian war are indicated. The main indicators of Ukraine's budgetary security over the past 10 years are analyzed. A significant deterioration of budgetary security indicators in 2022 is established. A significant decrease in the level of GDP in 2022 and its decisive impact on indicators of budgetary security are revealed. It is noted that the decrease in the level of budgetary security leads to a decrease in the level of debt security of the state. Forecast figures for certain budgetary security indicators are provided. The main directions for using budget funding for further strengthening of budgetary security are suggested.