bluuebunny/crossref_metadata_2025 huggingface dataset:
Validity and Reliability of The Cancer Loneliness and The Cancer-Related Negative Social Expectations Scale
Authors: KARA Ebru , ÖZEN ÇINAR İlgün
Published: August 2020

There is a need for cancer-specific tools to evaluate loneliness and cancer-related negative social expectations before developing interventions for cancer patients. The purpose of this study was to examine the reliability and validity of the Cancer Loneliness and the Cancer-related Negative Social Expectations Scale. Data were collected from 300 cancer patients registered to an oncology outpatient clinic of a University Hospital for this methodological study. In the data collection, Patient Information Form, Cancer Loneliness Scale and Cancer-related Negative Social Expectations Scale and the General Loneliness Scale were used. The Cronbach’s Alpha coefficient of the Cancer Loneliness Scale was found to be .88, Spearman-Brown correlation value was found to be .81, CFI, .98, GFI, .96, 𝑋2/SD, 2.99 and RMSEA .08. As for the Negative Social Expectations Scale, Cronbach alpha value was found as .82, Spearman-Brown correlation value .86, CFI 1.00, GFI 1.00, 𝑋2/SD 1.33 and RMSEA .02. The study revealed those both scales were highly reliable and indices of fit showed perfect fit. These scales are highly valid and reliable instruments for the Turkish society.
Reinterpretation of LHC Results for New Physics: Status and recommendations after Run 2
Authors: Abdallah Waleed , Salam Shehu Abdus , Ahmadov Azar , Ahriche Amine , Alguero Gaël , Allanach Ben , Araz Jack Y. , Arbey Alexandre , Arina Chiara , Athron Peter , Bagnaschi Emanuele Angelo , Bai Yang , Baker Michael J. , Balazs Csaba , Barducci Daniele , Bechtle Philip , Bharucha Aoife , Buckley Andy , Butterworth Jonathan , Cai Haiying , Campagnari Claudio , Cesarotti Cari , Chrzaszcz Marcin , Coccaro Andrea , Conte Eric , Cornell Jonathan M. , Corpe Louie , Danninger Matthias , Darmé Luc , Deandrea Aldo , Desai Nishita , Dillon Barry M. , Doglioni Caterina , Dutta Juhi , Ellis John , Ellis Sebastian , Fassi Farida , Feickert Matthew , Fernandez Nicolas , Fichet Sylvain , Flacke Thomas , Fuks Benjamin , Geiser Achim , Genest Marie-Hélène , Ghalsasi Akshay , Gonzalo Tomas , Goodsell Mark , Gori Stefania , Gras Philippe , Greljo Admir , Guadagnoli Diego , Heinemeyer Sven , Heinrich Lukas A. , Heisig Jan , Hong Deog Ki , Hryn'ova Tetiana , Huitu Katri , Ilten Philip , Ismail Ahmed , Jueid Adil , Kahlhoefer Felix , Kalinowski Jan , F. Kamenik Jernej , Kar Deepak , Kats Yevgeny , Khosa Charanjit K. , Khoze Valeri , Klingl Tobias , Ko Pyungwon , Kong Kyoungchul , Kotlarski Wojciech , Krämer Michael , Kraml Sabine , kulkarni suchita , Kvellestad Anders , Lange Clemens , Lassila-Perini Kati , Lee Seung-Joo , Lessa Andre , Liu Zhen , Lloret Iglesias Lara , Lorenz Jeanette M. , MacDonell Danika , Mahmoudi Farvah Nazila , Mamuzic Judita , Marini Andrea C. , Markowich Peter , Martinez Ruiz del Arbol Pablo , Miller David , Mitsou Vasiliki , Moretti Stefano , Nardecchia Marco , Neshatpour Siavash , Nhung Dao Thi , Osland Per , Owen Patrick H. , Panella Orlando , Pankov Alexander , Park Myeonghun , Porod Werner , Price Darren , Prosper Harrison , Raklev Are , Reuter Jürgen , Reyes-González Humberto , Rizzo Thomas , Robens Tania , Rojo Juan , Rosiek Janusz , Ruchayskiy Oleg , Sanz Veronica , Schmidt-Hoberg Kai , Scott Pat , Sekmen Sezen , Sengupta Dipan , Sexton-Kennedy Elizabeth , Shao Hua-Sheng , Shin Seodong , Silvestrini Luca , Singh Ritesh , Sinha Sukanya , Sonneveld Jory , Soreq Yotam , Stark Giordon H. , Stefaniak Tim , Thaler Jesse , Torre Riccardo , Torrente-Lujan Emilio , Unel Gokhan , Vignaroli Natascia , Waltenberger Wolfgang , Wardle Nicholas , Watt Graeme , Weiglein Georg , White Martin , Williamson Sophie L. , Wittbrodt Jonas , Wu Lei , Wunsch Stefan , You Tevong , Zhang Yang , Zurita José
Published: August 2020

We report on the status of efforts to improve the reinterpretation of searches and measurements at the LHC in terms of models for new physics, in the context of the LHC Reinterpretation Forum. We detail current experimental offerings in direct searches for new particles, measurements, technical implementations and Open Data, and provide a set of recommendations for further improving the presentation of LHC results in order to better enable reinterpretation in the future. We also provide a brief description of existing software reinterpretation frameworks and recent global analyses of new physics that make use of the current data.
Editorial Franciscanum 174
Authors: Bonilla Morales Jaime Laurence
Published: August 2020

En esta editorial se presenta una breve reflexión sobre el contexto de la crisis generada por el Covid-19 y la tarea permanente de las humanidades. Asimismo, se presentan los artículos de la sección de filosofía y teología.
Fenomenología de la sonoridad.
Authors: Pignalitti David Antonio
Published: August 2020

En las conferencias inéditas de Levinas en el Collège philosophique se analiza la concepción occidental del lenguaje como consecuencia de un paradigma lumínico de relación lógico-conceptual con el ser: un mundo silencioso que se revela en la luz. La fenomenología no habría logrado apartarse de la metafísica tradicional, que encierra y domina al ser que se da en la luz a través de la razón, reduciéndolo a la uniformidad. Levinas encuentra en la sonoridad del sonido una clave de interpretación filosófica con el potencial de diseñar una forma alternativa de relación con la existencia donde la alteridad se manifiesta como tal. Se propone, por lo tanto, el paradigma de la sonoridad como un refulgir del ser alternativo al de la luz.
La encarnación vista desde lo pagano. La lectura de Charles Péguy de Booz endormi de Victor Hugo
Authors: Molteni Agostino
Published: August 2020

Los cristianos y la teología leen la encarnación de Cristo como adviento e irrupción (avènement) de Dios en la historia de los hombres. Tomando ocasión de la lectura de Booz endormi de Victor Hugo, Charles Péguy presenta lo que él considera el único reconocimiento del acontecimiento (événement) de la encarnación por parte de un pagano (y de un bíblico). Esta lectura que al mismo tiempo es una presentación de un aspecto del pensamiento de Péguy sobre la encarnación, muestra a esta como una producción que también se refiere al hombre y para cuyo reconocimiento se necesitaría un método teológico que Péguy define como bergsoniano. De este modo, Péguy ofrece interrogaciones y un camino interesante para el pensamiento teológico y de la fe cristiana para volver a reflexionar sobre la verdadera humanidad del hebreo Jesús y sobre el significado que el hombre representa para el mismo Dios hecho carne.
El principio de beneficencia como articulador entre la teología moral, la bioética y las prácticas biomédicas
Authors: López Vélez Luis Emilio , Zuleta Salas Guillermo León
Published: August 2020

A través del presente ejercicio investigativo y hermenéutico se busca proponer la beneficencia como principio articulador entre la Teología Moral de la Persona, la Bioética y las Prácticas Biomédicas, con el fin de salvaguardar al ser humano de forma integral y desde el ámbito interdisciplinar, frente a la manipulación y menoscabo de la persona en su: dignidad, status antropológico, verdad ontológica y trascendente, lo cual nos lleva a proponer alternativas, dadas las nuevas circunstancias por las que atraviesa la humanidad; y es aquí donde adquiere resonancia proponer la Beneficencia como principio articulador entre estas tres ciencias, dado que ella, como principio, está en los tres saberes de forma implícita y explícita y, las cuales, por su misma esencia, tienen puntos de convergencia como son: la determinación de su carácter moral, su estatuto de servicio, la salvaguarda de la riqueza de la vida, el reconocimiento y respeto por la dignidad humana, el reconocimiento de la multidimensionalidad del ser, y el cuidado que requiere toda persona humana en su fragilidad y vulnerabilidad. Además de lo anterior se cuenta con un abordaje teórico sobre la bioética como saber interdisciplinar; los principios de la bioética y la relación de la teología moral de la persona con la bioética. El presente ejercicio investigativo fue llevado a cabo en un lapso de dos años.
Moros, San Francisco y los frailes en la serie de cuadros de la vida de san Francisco del Museo de Arte Colonial de San Francisco, Santiago de Chile
Authors: Alvarado Sánchez Nelson Manuel
Published: August 2020

En el marco de los 800 años de la celebración del encuentro de San Francisco y el Sultán, convocado por la Orden Franciscana, el presente artículo pretende indagar sobre la concepción de la imagen del moro en la sociedad colonial y, particularmente reflejados en la serie de 54 cuadros de la vida de san Francisco del Museo de Arte Colonial de San Francisco, Santiago de Chile, confeccionada en el siglo XVII en un taller del Cuzco y cuyo destino fue el Convento homónimo para la formación y contemplación de los religiosos, que nos permite descubrir su representación.

El moro representa el signo del individuo o del territorio pagano, en acción o contexto de violencia, pero capaz de la conversión. Estos aspectos son comunes a los prejuicios traídos por los colonizadores, marcados por la larga lucha en la península contra ellos y las políticas de expulsión de esta comunidad desde España.

El arte colonial, a su vez, fue un ejercicio de diálogo cultural que adaptó la cultura hispánica a la realidad del nuevo mundo, y, por tanto, permitió la lectura del moro trasladada a las dificultades y éxitos de la evangelización y a la violencia ejercida por los conquistadores.
A Brief Version of the Difficulties in Emotion Regulation Scale (DERS): Validity Evidence in Ecuadorian Population
Authors: Reivan-Ortiz Geovanny Genaro , Rodas Patricia Elizabeth Ortiz , Reivan Ortiz Patricia Natali
Published: August 2020

Due to the scarcity of evaluation instruments on the construct of difficulties in emotional regulation in the Ecuadorian university context, the objective of the present study was to adapt linguistically and to study the psychometric properties of the Difficulty Scale in Emotional Regulation (DERS) in a sample of Ecuadorian university students. A non-probability sample of 1172 participants between 17 and 32 years of age (M = 21.99; DT = 2.49), which consisted of 58.6% women and 41.4% men, was used. The research was carried out in three stages. The first study evaluated the Ecuadorian linguistic adaptation of the scale. The second study referred to the factorization by main axes identifying five factors (Lack of emotional understanding; Limited access to regulation strategies; Difficulties in impulse control; Interferences in goal-directed behaviors; Lack of emotional clarity) theoretically interpretable, which explain 49.22% of the variance. The third study developed a confirmatory factor analysis that specified an acceptable fit of the model (GFI = .95; AGFI =.95; NFI = .94; RMR = .11). The reliability coefficients are acceptable as .90 Cronbach’s alpha and .91 McDonald’s omega. In conclusion, it is mentioned that the Ecuadorian version of the DERS in a university sample exhibits good psychometric characteristics of internal structure and responses.
Psychometric Properties of a Brief Screening Measure for ADHD in Adults
Authors: Bakare Blessing , Jordanova Vesna
Published: August 2020

The use of screening tools is an effective and practical approach within the clinical diagnostic assessment of attention deficit hyperactivity disorder (ADHD) in adults. Existing screening measures for adult ADHD have focused on a younger population. Subsequently, the current study aimed to evaluate the utility and general usability of an adapted four-item screening tool for adult ADHD: a brief version of the Wender Utah Rating Scale (WURS-brief), within a middle-aged population. The sample consisted of 69 adults, aged between 30 and 63 (age M= 45, SD=6.95), who had been referred to a specialist adult ADHD outpatients clinic. Using factor analysis, the WURS-brief screening measure was compared to existing ADHD diagnostic tools that were used as reference measures within the analysis. The WURS-brief had respectable sensitivity when compared with existing diagnostic tools. This study highlights the importance of validating brief screening measures for middle-aged adults with ADHD within clinical settings and offers suggestions for future research.
Punitive Violence against Children: A Psychoeducational Parenting Program to Reduce Harsh Disciplining Practices and Child Beating in the Home
Authors: Ofoha Dorothy , Ogidan Rotimi
Published: August 2020

While parental harsh disciplining of children is a global concern, children living in Nigeria often experience particularly high levels of harsh discipline. Constrained by the lack of parenting skills to effectively manage children, most Nigerian parents rely too heavily on the use of violent methods in the disciplining of their children, which poses a huge threat to their well-being and development. Given the high levels of harsh parenting and the lack of understanding of its harms, we set out to develop a program of intervention called Psychoeducational parenting program to prevent violence against children (PEPVAC), guided by psychological principles of social learning theory, to help parents reverse the trend. We tested the effectiveness of the program using a quasi-experimental design with questionnaire and observation as data collection tools. Participants were 300 parents of children age 3-12 years, who endorsed using harsh discipline. Parents (n = 150) who received the 8-week intervention were compared with parents in the control group (n = 150). A mixed-model ANOVA revealed that the PEPVAC parents demonstrated a reduced use of harsh disciplinary tactics and a decreased incidence of parents beating their children compared to parents in the control group who continued with business-as-usual. Findings suggest that PEPVAC can be a useful intervention tool in the prevention of punitive violence against children, especially in a culturally-oriented country like Nigeria with over 91 million population of children who are at risk of disciplinary violence in the home.
Adaptive Non-Immersive VR Environment for Eliciting Fear of Cockroaches: A Physiology-Driven Approach Combined with 3D-TV Exposure
Authors: Rosa Pedro J. , Luz Filipe , Júnior Roberto , Oliveira Jorge , Morais Diogo , Gamito Pedro
Published: August 2020

Non-immersive VR environments are related to the least interactive application of VR techniques, such that interaction with the VR environment can occur commonly by 3D-TV without full immersion into the environment. This study presents how 3D-TV exposure combined with physiology recording can elicit fear of cockroaches among individuals with different levels of fear. Thirty-six participants, set apart into three fear groups (low vs. moderate vs. high), were exposed to VR environment with cockroaches for 4 minutes while recording and using cardiac activity as input to the VR environment. Results revealed significant effects on self-report measures and heart rate between different fear groups. Moreover, participants with higher levels of fear were more likely to trigger cockroaches into the scenario due to their cardiac acceleration. Overall results suggest that our physiology-driven VR environment is valid for fear elicitation while having potential use in therapeutic domain.
Dating Victimization Among Chilean University Students: Gender Roles and Christian Spirituality
Authors: Pérez Sánchez Beatriz , Rosas Wellmann Diego Adolfo Fernando , Rodríguez-Díaz Javier
Published: August 2020

This correlational-multivariate, cross-sectional quantitative study differentially determined by sex the prevalence of dating victimization by violence, the self-perception of victimization, and the attempt to ask for help to end a problematic relationship, as well as analyzing the explanatory weight of the attitudes to gender roles and Christian spirituality on these variables. The study sample, non-probabilistic and by convenience, was comprised of 759 Chilean university students. 63.9% were women and the average age was 20.5 years (SD=1.69). Men report suffering more physical violence and violence by coercion, and women have more tools to perceive their situation of victimization and to ask for help. Transcendent attitudes are a protective factor, stereotypes a risk factor, and the influence of religion is paradoxical. However, the explanatory power of these variables is low. In conclusion, dating violence is a problem present in the study sample, with the experience of victimization being different for men and women.
IJPR en PubMed Central. Un aporte a la producción y edición científica de América Latina
Authors: Alzate-Pamplona Fraidy Alonso
Published: August 2020

Este artículo tuvo dos objetivos: 1. Identificar las revistas latinoamericanas en PMC, discriminarlas por país, áreas de conocimiento e indexaciones en Scopus y Web of Science (WOS). 2. Identificar las revistas colombianas, especialmente aquellas que podrían ser potenciales publicaciones para PMC. Para dar cumplimiento a los objetivos, se minó el listado de revistas de PMC, la base de datos de Scimago Journal & Country Rank (SJR), la colección principal de WOS, la base de datos del índice bibliográfico Publindex y se categorizaron las revistas por área de conocimiento siguiendo el modelo de clasificación de la Organización para la Cooperación y el Desarrollo Económicos (OCDE). Como resultados se encontraron que de las 3194 revistas indexadas en PMC, 40 son de América Latina (1,25%). De estas, 39 se encuentran en Scopus y 25 en WOS, 36 son de Brasil y 2 pertenecen al área de la psicología. En Colombia se encontraron 275 revistas indexadas en Publindex, 63 son de las ciencias médicas y de la salud, ciencias biológicas y de psicología. De estas, 27 se encuentran en Scopus, 8 en WOS y 2 en PMC. Se llegó a la conclusión que hay una baja indexación en PMC de revistas latinoamericanas y se destacó la inclusión de dos revistas de psicología. Colombia cuenta con revistas de calidad y reconocimiento internacional que pueden avanzar a la indexación en MEDLINE y PMC.
In the face of a pandemic: The COVID-19 Infodemic
Authors: Cuartas-Arias Mauricio
Published: August 2020

Editorial
Aprendizagem de Competências além da Sala de Aula: o papel dos programas extracurriculares
Authors: Souza Júnior Roberto Rodrigues de , Amaro Rubens De Araújo
Published: August 2020

O objetivo desta pesquisa qualitativa foi identificar e analisar as semelhanças e diferenças nos processos de aprendizagem e desenvolvimento de competências de estudantes, participantes nos programas extracurriculares Empresa Júnior (EJ), Iniciação Científica (IC) e Programa de Educação Tutorial (Pet). A investigação foi realizada com 15 estudantes dos cursos de graduação em Administração, matutino e noturno, da Universidade Federal do Espírito Santo. A coleta de dados foi realizada por meio de entrevistas semiestruturadas. Os dados foram analisados por meio do protocolo de análise qualitativa proposto por Gibbs (2009). Os achados sugerem que os processos de aprendizagem, vistos sob as lentes das aprendizagens situada, social, informal e incidental, contribuíram com o desenvolvimento de competências sociais, de gestão, de resolução de problemas, de comunicação e de investigação científica. Esta pesquisa destaca a importância dos programas extracurriculares como recursos que potencializam o desenvolvimento de competências dos estudantes. Isso ocorre, em grande medida, porque esses programas proporcionam a possibilidade de os estudantes realizarem a aproximação entre teoria e prática, contribuindo para o preenchimento das lacunas de formação existentes no modelo tradicional de ensino/aprendizagem universitário, baseada na transmissão/reprodução de conteúdo.
Feiras Colaborativas e Economia Criativa em Caruaru, Pernambuco
Authors: Santos Elisabeth Cavalcante dos , Silva Camila De Melo
Published: August 2020

Este trabalho tem como objetivo analisar as feiras colaborativas que constituem a Economia Criativa da cidade de Caruaru-PE. Para isso, buscou-se, identificar o perfil dos seus empreendimentos e empreendedores(as), e compreender como ocorrem os processos de produção, circulação e consumo. Foi adotada abordagem qualitativa, e a pesquisa se caracteriza como descritiva. Foram realizadas visitas a 5 feiras colaborativas, e 8 entrevistas abertas e semiestruturadas com produtores(as) locais que participam das feiras estudadas. Como resultados, constatou-se que as feiras colaborativas têm valorizado marcas autorais locais e gerado oportunidades para produtores iniciantes exporem, divulgarem e venderem seus produtos, bem como realizarem parcerias. Verificou-se também que a maioria dos empreendedores que participam das feiras são mulheres, e que estas sentem diferenças em relação às feiras colaborativas independentes, e aquelas promovidas por órgãos públicos, como a prefeitura da cidade. Ressaltou-se a importância dessas feiras na inserção profissional de jovens recém-formados, que possuem empreendimentos com forte posicionamento social e ambiental, o que os diferencia dos negócios locais. Por fim, dois pontos foram destacados: a importância de se compreender a dinâmica da economia criativa a partir do contexto na qual ela se insere ; e que a atuação em feiras aparece como alternativa à situação desemprego, por meio de uma inserção num mercado informal, atrelada a uma situação de vulnerabilidade dos agentes entrevistados.
Marketing, Tecnologia e Planejamento Como Diferenciais Competitivos Para Alavancar o Dark Tourism e o Desenvolvimento Local e Regional
Authors: Boff Vilmar Antônio , Bordim Jonas , Wbatuba Berenice Beatriz Rossner , Wittmann Milton Luiz , Falkembach Fabiana Regina
Published: August 2020

Competitividade, novas tecnologias de gestão e de informação e a alta sazonalidade e evolução de mercado, em especial no setor turístico, influiu nas estratégias de marketing tornando-as em instrumento importante para o planejamento do desenvolvimento local e regional. Esse artigo, resultante de estudos e pesquisas desenvolvidas pelo Grupo de Pesquisas ESADI - Estudos Setoriais em Administração, Desenvolvimento e Inovação, tem por objetivo evidenciar como um plano de Marketing pode alavancar o desenvolvimento do setor turístico, especialmente em lugares que se enquadram no conceito de Dark Tourism. Nesse sentido, trata-se de conhecer o comportamento do consumidor e obter informações necessárias para a elaboração de um plano de Marketing de forma a impulsionar o turismo local e regional. Quanto aos aspectos metodológicos trata-se de um referencial teórico cujos resultados identificam as vantagens de operar a gestão do turismo a partir de um planejamento que contempla a atração e prospecção de clientes a partir de cinco ações estratégias: i) criação de uma marca; ii) consolidação da imagem simbólica de Sepé Tiarajú; iii) implementação do aplicativo (APP) missões; iv) Criação do roteiro missões; e v) intensificação da estrutura do espetáculo som e luz. A pesquisa aponta as indicações que constam num plano de ação, cujo propósito disponibiliza um conjunto de possíveis benefícios para o desenvolvimento turístico do Sítio Arqueológico de São Miguel Arcanjo na cidade de São Miguel das Missões/RS/Brasil inserido no contexto dos Sete Povos das Missões.
Twenty years of asset management research for Dutch drinking water utilities
Authors: Beuken R. , Eijkman J. , Savic D. , Hummelen A. , Blokker M.
Published: August 2020

This paper gives an overview of the asset management landscape on drinking water in the Netherlands and twenty years of research on this topic executed by KWR in close collaboration with water companies. A description is given of research questions and the international developments in the field of asset management. This is followed by the developments on asset management at the Dutch water company Evides. Twenty years of asset management research at KWR is presented in five phases, showing a transition from the question of how can the concepts of asset management help to better plan the replacement of distribution networks, towards integrated decision making on the asset system as a whole. A focal point for research could be how research can contribute to creating value for water companies. More formal information and improved modelling will continue to play a central role; however, attention is required for making use of expert knowledge, scenario building, data quality and the integration of information of technical, financial and societal origin.
Andrographolide Mitigates Unfolded Protein Response Pathway and Apoptosis Involved in Chikungunya Virus Infection
Authors: Gupta Swati , Mishra Kamla Prasad , Kumar Bhuvnesh , Singh Shashi Bala , Ganju Lilly
Published: August 2020

Background:

Chikungunya virus (CHIKV) is an arthropod-borne RNA virus which induces
host Endoplasmic Reticulum (ER) stress by accumulating unfolded or misfolded proteins.
ER stress activates the unfolded protein response (UPR) pathway to enable proper protein folding
and maintain cellular homeostasis. There is no approved drug or vaccine available for CHIKV treatment,
therefore, a pharmacological countermeasure is warranted for preventing CHIKV infection.

Objective:

With a view to find a treatment modality for chikungunya infection, “andrographolide”,
a plant-derived diterpenoid with reported antiviral, anti-inflammatory and immunomodulatory effects,
was used to investigate its role in chikungunya induced unfolded protein stress and apoptosis.

Methods:

Cells and supernatant collected on andrographolide and VER-155008, a GRP78 inhibitor,
treatment in CHIKV infected and mock-infected THP-1 cells were tested for differential expression
of UPR pathway proteins including GRP78, PERK, EIF-2α, IRE-1α, XBP-1 and ATF6. Furthermore,
the inflammasome and apoptosis pathway proteins, i.e., caspase-1, caspase-3 and PARP,
were tested by immunoblotting, and cytokines, i.e., IL-1β, IL-6 and IFN-γ were tested by ELISA.

Results:

Andrographolide treatment in CHIKV infected THP-1 cells significantly reduced IRE1α
and downstream spliced XBP1 protein expression. Furthermore, CHIKV induced apoptosis and viral
protein expression were also reduced on andrographolide treatment. A comparative analysis of
andrographolide versus VER-155008, confirmed that andrographolide surpasses the effects of
VER-155008 in suppressing the CHIKV induced ER stress.

Conclusion:

The study, therefore, confirms that andrographolide is a potential remedy for chikungunya
infection and suppresses CHIKV induced ER stress and apoptosis.
Advancement in Pharmacological Activities of Benzothiazole and its Derivatives: An Up to Date Review
Authors: Sumit  , Kumar Arvind , Mishra Arun Kumar
Published: August 2020

Benzothiazole is a heterocyclic aromatic and bicyclic compound in which, benzene ring is
attached with thiazole ring. This nucleus is established in marine as well as terrestrial natural compounds.
The benzothiazole skeleton is established in a broad variety of bioactive heterocycles and
natural products. The benzothiazole nucleus is considered as the principle moiety in several biologically
active compounds. Over the decade, chemists are paying more attention towards the revision of
the biological and therapeutic activities such as antimicrobial, analgesic, antiinflammatory, antitubercular,
antiviral and antioxidant of benzothiazole containing compounds. The molecular structures of a
number of potent drugs including Frentizole, Pramipexole, Thioflavin T and Riluzole etc., are based
on benzothiazole skeleton. The present work is the compilation and presentation of all available information
in a systematic manner with an aim to present the findings in a way, which may be beneficial
for future research.
Efficacy and Safety of Antiplatelet Therapies in Symptomatic Peripheral Artery Disease: A Systematic Review and Network Meta-Analysis
Authors: De Carlo Marco , Di Minno Giovanni , Sayre Tobias , Fazeli Mir Sohail , Siliman Gaye , Cimminiello Claudio
Published: August 2020

Background:

Clopidogrel monotherapy is guideline-recommended in symptomatic peripheral
artery disease (PAD). The advent of new antithrombotic strategies prompts an updated
analysis of available evidence on antiplatelet therapy for PAD.

Methods:

We searched MEDLINE, Embase and CENTRAL through January 2019 for randomised
controlled trials and observational studies comparing antiplatelet therapies as monotherapy, dual
therapy, or combination with anticoagulants. Efficacy (major adverse cardiovascular events, acute
or chronic limb ischaemia, vascular amputation, peripheral revascularisation) and safety (all-cause
mortality and overall bleeding) outcomes were evaluated via Bayesian network meta-analyses.

Results:

We analysed 26 randomised controlled trials. Clopidogrel (hazard ratio, HR, 0.78; 95%
credible interval [CrI] 0.65-0.93) and ticagrelor (HR 0.80; 95% CrI 0.65-0.98) significantly reduced
major adverse cardiovascular events risk compared with aspirin. No significant difference
was observed for dual antiplatelet therapy with clopidogrel and aspirin. Vorapaxar significantly reduced
limb ischaemia and revascularisation compared with placebo, while dual antiplatelet therapy
with clopidogrel and aspirin showed a trend for reduced risk of amputation compared with aspirin
(risk ratio 0.68; 95% CrI 0.43-1.04). For all-cause mortality, picotamide, vorapaxar, dipyridamole
with aspirin, and ticlopidine showed a significantly lower risk of all-cause mortality vs aspirin.
Clopidogrel and ticagrelor showed similar overall bleeding risk vs aspirin, while dual antiplatelet
therapy with clopidogrel and aspirin significantly increased bleeding risk.

Conclusion:

This updated network meta-analysis confirms that clopidogrel significantly decreases
the risk of major adverse cardiovascular events compared with aspirin, without increasing bleeding
risk. Clopidogrel should remain a mainstay of PAD treatment, at least in patients at higher bleeding
risk.
Recent Advances in Heterostructured Photocatalysts for Degradation of Organic Pollutants
Authors: Sun Chen-Jing , Zhao Li-Ping , Wang Rui
Published: August 2020

With the development of industrialization, global environmental pollution and energy crisis
are becoming increasingly serious. Organic pollutants pose a serious health threat to human beings
and other organisms. The removal of organic pollutants in the environment has become a global
challenge. The photocatalytic technology has been widely used in the degradation of organic pollutants
with its characteristics of simple process, high efficiency, thorough degradation and no secondary
pollution. However, the single photocatalyst represented by TiO2 has the disadvantages of low
light utilization rate and high recombination rate of photocarriers. Building heterojunction is considered
one of the most effective methods to enhance the photocatalytic performance of a single photocatalyst,
which can improve the separation efficiency of photocarriers and the utilization of visible
light. The classical heterojunction can be divided into four different cases: type I, type II, p-n heterojunctions
and Z-scheme junction. In this paper, the recent progress in the treatment of organic pollution
by heterostructure photocatalysts is summarized, and the mechanism of heterostructure photocatalysts
for the treatment of organic pollutants is reviewed. It is expected that this paper can deepen
the understanding of heterostructure photocatalysts and provide guidance for high efficient photocatalytic
degradation of organic pollutants in the future.
A Comprehensive Overview of the Synthesis of Tetrahydrocarbazoles and its Biological Properties
Authors: Chakroborty Subhendu , Panda Pravati
Published: August 2020

Tetrahydrocarbazoles (THC) is a privileged structural scaffold containing natural indole as
the central moiety. This extraordinary skeleton features in a plethora of naturally occurring pharmacological
compounds and alkaloids exhibiting a significant inhibitory activity such as antibacterial,
protein kinase inhibitor, and tumor growth inhibitor, etc. Due to its versatile biological properties, it
always gains considerable attention among the scientific community. The main objective of this review
is to make a comprehensive reference work on the synthesis and biological properties of THCs,
thus targeting a broad audience on the assessment of various catalysts along with their reaction condition,
mechanism of action, and yield, which are categorized into three groups: 1) organocatalyzed
reactions; 2) TfOH catalyzed reactions; 3) metal-catalyzed reactions and 4) miscellaneous.
Synthesis and In Vitro anti-HCV and Antitumor Evaluation of Schisandronic Acid Derivatives
Authors: Zhang Kai-Xia , Qian Xi-Jing , Zheng Wei , Cai Meng-Cheng , Ma Ying , Zhang Da-Zhi , Yu Shi-Chong , Meng Qing-Guo , Jin Yong-Sheng
Published: August 2020

Background:

Schisandronic acid (SA), a triterpenoid from fruits of Schisandra sphenanthera,
inhibited pan-genotypic HCV entry into human hepatocytes by interfering with virion-cell
membrane fusion. It was a promising lead compound for the development of novel HCV entry inhibition
agents.

Objective:

The aim of the present study is to search for compounds with more potent anti-HCV and
antitumor activities and explore SARs. A series of novel derivatives of SA were designed and synthesized
and evaluated for in vitro, their anti-HCV and antitumor activities.

Methods:

SA derivatives were synthesized by reduction, condensation, esterification or amidation.
The anti-HCV activity of title compounds was tested by inhibition on HCVcc infection of Huh7
cells, and a preliminary MOA study was conducted by determining inhibition on HCVpp entry into
Huh7 cells. The antitumor activity in vitro was determined by MTT methods.

Results:

In total, 24 novel derivatives were synthesized. Most of the compounds inhibited HCVcc
infection. Compounds 5h and 6 showed the most potent anti-HCVcc activities and inhibition of
HCVpp entry into Huh7 cells without obvious cytotoxicity. Most of the title compounds showed potent
in vitro antitumor activities against Bel7404 and SMMC7721 tumor cell lines. Compounds 5j
and 6 exhibited more potent antitumor activity than positive control SA and DOX.

Conclusion:

Structural modification of SA could lead to the discovery of potent anti-HCV or antitumor
agents. Compounds 5h, 5j and 6 were promising lead compounds for development of novel HCV
entry inhibition or antitumor agents.
Synthesis and Structure-Activity Relationship Studies of N-monosubstituted Aroylthioureas as Urease Inhibitors
Authors: Ni Wei-Wei , Fang Hai-Lian , Ye Ya-Xi , Li Wei-Yi , Liu Li , Fu Zi-Juan , Dawalamu  , Zhu Wen-Yan , Li Ke , Li Fang , Zou Xia , Ouyang Hui , Xiao Zhu-Ping , Zhu Hai-Liang
Published: August 2020

Background:

Thiourea is a classical urease inhibitor which is usually used as a positive
control, and many N,N'-disubstituted thioureas have been determined as urease inhibitors. However,
due to steric hindrance, N,N'-disubstituted thiourea motif could not bind urease as thiourea. On
the contrary, N-monosubstituted thiourea with a tiny thiourea motif could theoretically bind into
the active pocket as thiourea.

Objective:

A series of N-monosubstituted aroylthioureas were designed and synthesized for evaluation
as urease inhibitors.

Methods:

Urease inhibition was determined by the indophenol method and IC50 values were calculated
using computerized linear regression analysis of quantal log dose-probit functions. The kinetic
parameters were estimated via surface plasmon resonance (SPR) and by nonlinear regression
analysis based on the mixed type inhibition model derived from Michaelis-Menten kinetics.

Results:

Compounds b2, b11, and b19 reversibly inhibited urease with a mixed mechanism, and
showed excellent potency against both cell-free urease and urease in the intact cell, with IC50 values
being 90- to 450-fold and 5- to 50-fold lower than the positive control acetohydroxamic acid,
respectively. The most potent compound b11 showed an IC50 value of 0.060 ± 0.004μM against
cell-free urease, which bound to urea binding site with a very low KD value (0.420±0.003nM) and a
very long residence time (6.7 min). Compound b11 was also demonstrated to have very low cytotoxicity
to mammalian cells.

Conclusion:

The results revealed that N-monosubstituted aroylthioureas bound to the active site of
urease as expected, and represent a new class of urease inhibitors for the development of potential
therapeutics against infections caused by urease-containing pathogens.
Organosulphur Compounds Induce Apoptosis and Cell Cycle Arrest in Cervical Cancer Cells via Downregulation of HPV E6 and E7 Oncogenes
Authors: Ansari Irfan A. , Ahmad Afza , Imran Mohammad A. , Saeed Mohd , Ahmad Irfan
Published: August 2020

Background:

The quest for strong, safe and cost-effective natural antiproliferative agents that could
reduce cancer has been the focus now a days. In this regard, the organosulfur compounds from garlic (Allium
sativum L.), like Diallyl Sulfide (DAS) and Diallyl Disulfide (DADS), have been shown to exhibit potent
antiproliferative and anticancer properties in many studies. However, the potential of these compounds against
viral oncoproteins in cervical cancer has not been fully elucidated yet.

Objective:

The objective of this study was to analyze the antiproliferative and apoptotic properties of DADS and
DAS in HPV16+ human cervical cancer Caski cell line.

Methods:

Caski (cervical cancer cells) were cultured and followed by the treatment of various concentrations of
organosulphur compounds (DADS and DAS), cell viability was measured by MTT assay. The apoptotic assay
was performed by DAPI and Hoechst3342 staining. Reactive Oxygen Species (ROS) was estimated by DCFDA
staining protocol. The distributions of cell cycle and apoptosis (FITC-Annexin V assay) were analyzed by flow
cytometry. Finally, gene expression analysis was performed via quantitative real time PCR.

Results:

Our results showed that DAS and DADS exerted a significant antiproliferative effect on Caski cells by
reducing the cell viability and inducing a dose-related increment in intracellular ROS production along with
apoptosis in Caski cells. DAS and DADS also induced cell cycle arrest in G0/G1 phase, which was supported by
the downregulation of cyclin D1 and CDK4 and upregulation of CDK inhibitors p21WAF1/CIP1 and p27KIP1
in Caski cells. Additionally, DAS and DADS lead to the downregulation of viral oncogene E6 and E7 and restoration
of p53 function.

Conclusion:

Thus, this study confirms the efficacy of both the organosulfur compounds DADS and DAS
against cervical cancer cells.
The Effects of Pemafibrate in Japanese Patients with Type 2 Diabetes Receiving HMG-CoA Reductase Inhibitors
Authors: Kusunoki Masataka , Sakazaki Takahiko , Tsutsumi Kazuhiko , Miyata Tetsuro , Oshida Yoshiharu
Published: August 2020

Objective:

The combination therapy of HMG-CoA reductase inhibitors (statins), which are anti-hyperlipidemia agents, and fibrates may increase the risk of hepatic dysfunction and myopathy, so this combination required careful administration for patients. In the present study, we evaluated the effects of combination therapy of pemafibrate, a novel fibrate and statins.

Methods:

We administered pemafibrate for 6 months as an add-on to statin therapy in 27 type 2 diabetes patients with dyslipidemia already receiving statins for 6 months (combination group), and examined the efficacy and safety of the combination therapy in comparison with a pemafibrate monotherapy group.

Results:

In the combination group, a decrease in serum total cholesterol levels was observed after 6
months of pemafibrate treatment compared to baseline, along with an increase in HDL-cholesterol.
While serum triglyceride level was reduced, HbA1c level was elevated in both the groups. Serum
creatinine kinase level, which is an indicator of myopathy, was lowered in the combination group.
In addition, a decrease in γ-glutamyl transpeptidase, a parameter of hepatic dysfunction, was observed
in the combination group.

Conclusion:

The statin-pemafibrate combination therapy in type 2 diabetes patients with dyslipidemia improved lipid metabolism safely without increasing the risk of hepatic dysfunction and myopathy.
Pivotal Role of Chirality in Photoelectrocatalytic (PEC) Water Splitting
Authors: Zhang Wenyan , Liu Fei , Hu Yingfei , Yang Weimin , Guan Hangmin , Hao Lingyun , Lu Gongxuan
Published: August 2020

For decades, the over-exploitation of fossil fuel has made it urgent to develop alternative
energy. Photoelectrochemical (PEC) water splitting is a promising approach to generate hydrogen,
which is referred to as the fuel of the future due to its high enthalpy of combustion and zero pollution.
Though impressive progress has been made over the years, PEC water splitting efficiency is
still far from volume production of hydrogen, and more efforts are required to reduce the overpotential,
inhibit the yield of hydrogen peroxide by-product, improve the PEC current density, improve
light-harvesting capability, and develop low-cost earth-abundant catalysts. Recently, chirality has
shown to play a pivotal role in addressing the issues of PEC water splitting via the effect of chiralinduced
spin controlling and chiral-enhanced light harvesting. It is high time to pay attention to the
art of chirality in promoting water splitting efficiency. Herein, recent progress in this field is reviewed,
the approaches to introducing chirality into photo/electronic catalysts for PEC water splitting
are summarized, characterization techniques applied in this research field are summed up, the
challenges of chirality-enhanced PEC water splitting are discussed, and based on the present
achievements, its bright future is anticipated.
Examining Patterns of Information Exchange and Social Support in a Web-Based Health Community: Exponential Random Graph Models
Authors: Liu Xuan , Jiang Shan , Sun Min , Chi Xiaotong
Published: August 2020

Background

Although an increasing number of studies have attempted to understand how people interact with others in web-based health communities, studies focusing on understanding individuals’ patterns of information exchange and social support in web-based health communities are still limited. In this paper, we discuss how patients’ social interactions develop into social networks based on a network exchange framework and empirically validate the framework in web-based health care community contexts.

Objective

This study aims to explore various patterns of information exchange and social support in web-based health care communities and identify factors that affect such patterns.

Methods

Using social network analysis and text mining techniques, we empirically validated a network exchange framework on a 10-year data set collected from a popular web-based health community. A reply network was extracted from the data set, and exponential random graph models were used to discover patterns of information exchange and social support from the network.

Results

Results showed that reciprocated information exchange was common in web-based health communities. The homophily effect existed in general conversations but was weakened when exchanging knowledge. New members in web-based health communities tended to receive more support. Furthermore, polarized sentiment increases the chances of receiving replies, and optimistic users play an important role in providing social support to the entire community.

Conclusions

This study complements the literature on network exchange theories and contributes to a better understanding of social exchange patterns in the web-based health care context. Practically, this study can help web-based patients obtain information and social support more effectively.
Hospital Epidemics Tracker (HEpiTracker): Description and pilot study of a mobile app to track COVID-19 in hospital workers
Authors: Soriano Joan B , Fernández Esteve , de Astorza Álvaro , Pérez de Llano Luis A , Fernández-Villar Alberto , Carnicer-Pont Dolors , Alcázar-Navarrete Bernardino , García Arturo , Morales Aurelio , Lobo María , Maroto Marcos , Ferreras Eloy , Soriano Cecilia , Del Rio-Bermudez Carlos , Vega-Piris Lorena , Basagaña Xavier , Muncunill Josep , Cosio Borja G , Lumbreras Sara , Catalina Carlos , Alzaga José María , Gómez Quilón David , Valdivia Carlos Alberto , de Lara Celia , Ancochea Julio
Published: August 2020

Background

Hospital workers have been the most frequently and severely affected professional group during the COVID-19 pandemic, and have a big impact on transmission. In this context, innovative tools are required to measure the symptoms compatible with COVID-19, the spread of infection, and testing capabilities within hospitals in real time.

Objective

We aimed to develop and test an effective and user-friendly tool to identify and track symptoms compatible with COVID-19 in hospital workers.

Methods

We developed and pilot tested Hospital Epidemics Tracker (HEpiTracker), a newly designed app to track the spread of COVID-19 among hospital workers. Hospital staff in 9 hospital centers across 5 Spanish regions (Andalusia, Balearics, Catalonia, Galicia, and Madrid) were invited to download the app on their phones and to register their daily body temperature, COVID-19–compatible symptoms, and general health score, as well as any polymerase chain reaction and serological test results.

Results

A total of 477 hospital staff participated in the study between April 8 and June 2, 2020. Of note, both health-related (n=329) and non–health-related (n=148) professionals participated in the study; over two-thirds of participants (68.8%) were health workers (43.4% physicians and 25.4% nurses), while the proportion of non–health-related workers by center ranged from 40% to 85%. Most participants were female (n=323, 67.5%), with a mean age of 45.4 years (SD 10.6). Regarding smoking habits, 13.0% and 34.2% of participants were current or former smokers, respectively. The daily reporting of symptoms was highly variable across participating hospitals; although we observed a decline in adherence after an initial participation peak in some hospitals, other sites were characterized by low participation rates throughout the study period.

Conclusions

HEpiTracker is an already available tool to monitor COVID-19 and other infectious diseases in hospital workers. This tool has already been tested in real conditions. HEpiTracker is available in Spanish, Portuguese, and English. It has the potential to become a customized asset to be used in future COVID-19 pandemic waves and other environments.

Trial Registration

ClinicalTrials.gov NCT04326400; https://clinicaltrials.gov/ct2/show/NCT04326400