bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Low Fat and Low Cholesterol Diet Intervention on LDL Subgroups in Dyslipidemic Patients: Epidemiological Observational Study
Authors: KAÇAR MUTLUTÜRK Ülger , ÇİÇEK Betül , BAYRAM Fahri , DOĞRUEL Fatma
Published: September 2023

Aim: According to studies, the individual cardiovascular disease (CVD) risk is predicted and low density lipoprotein cholesterol (LDL

cholesterol) sub-group concentration better than LDL cholesterol. High fat and cholesterol intakes are generally considered to pose a risk

on CVD. The purpose of this study is to analogize LDL sub-group concentration pre and post a diet with LowFat and LowCholesterol

written a prescription to dyslipidemic sicks along 3 months.

Material and Methods: Diagnosticated dyslipidemia sicks (n=47) on the part of the endocrinologist were pursued along 3 months

via a LowFat, LowCholesterol diet upon a lasting a month basis, on condition that they were proper for each. Before and after dietary

intervention periods, biochemical parameters and anthropometric measurements were compared.

Results: A sum of 47 participants (15 men and 32 women) with an average age of 48.51±9.86 years were involved. 13 women were at

premenopausal and 19 women were at postmenopausal stages of 32 women involved. Small dense LDL (Sd-LDL) decreased from 11.0

(0.0-37.0) mg/dL at the beginning to 7.0 (0.0-68.1) mg/dL after the dietary intervention, but this decline was unimportant (p=0.686).

Midbands (MiDC, MidB, MidA) subgroups of intermediate density lipoprotein cholesterol (IDL-cholesterol) declined considerably after

dietary interference (p
COVID-19 Karantina Sürecinin Diyabetik Makula Ödemi Tedavisine Etkileri
Authors: BİLİCİ Serdar , SELÇUK Neriman , GÜLTEKİN-EROL Tuba , UĞURBAŞ Suat Hayri
Published: September 2023

Amaç: COVID-19 pandemisi nedeniyle tedaviye verilen aranın diyabetik maküla ödemi (DMÖ) olgularındaki anatomik ve fonksiyonel

etkilerinin değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntemler: COVID-19 nedeniyle anti-vasküler büyüme faktörü (VEGF) tedavisine ara verilen DMÖ olguları çalışmaya dahil

edildi. Olguların yaş, cinsiyet, tedaviye verilen ara süresi ve tekrar tedavi sonrası enjeksiyon sayısı ile takip süresi kaydedildi. Karantina

öncesi son vizitleri (V0), karantina sonrası ilk (V1) ve son vizitlerindeki (V2) görme keskinlikleri (GK) ve optik koherans tomografi

ile santral makula kalınlığı (SMK) değerlendirildi. Olgular tedaviye verilen ara süresine göre 18 hafta ve altı (Grup-1) ile 18 hafta üzeri

(Grup-2) olarak alt gruplara ayrıldı ve analiz edildi.

Bulgular: Çalışmaya yaş ortalaması 63,1 yıl (42-80 yıl arası) olan 89 olgunun 89 gözü dahil edildi. Pandemi sürecinde tedaviye verilen

ara ortalaması 21,03 hafta (12-48 hafta) olarak saptandı. Tekrar tedaviye başlanan olguların ortalama takip süresi 31,2 hafta (8 - 52 hafta)

olup bu süreç içerisinde ortalama 2,98 (1-8) anti-VEGF tedavi uygulanmıştı. Tüm grupta V0, V1 ve V2 vizitlerindeki ortalama GK

sırasıyla 0,64, 0,64 ve 0,63 LogMAR (p=0,168), ortalama SMK değerleri sırasıyla 383,06, 434,82 ve 373,27 mikron (p
The COVID-19 Pandemic and the Organization of Pediatric Health Services in Portugal - a Medical perspective
Authors: Fraga Ana , Vale Sara , Moleiro Pascoal
Published: September 2023

The COVID-19 pandemic presents a new and significant infection control challenge within healthcare units. Therefore, there was a need to reorganize and restructure the Pediatric Services nationwide whilst establishing efficient protection measures. This study aims to portray physicians perspective on their hospitals measures implemented during early phase of the COVID-19 pandemic. Analytical cross-sectional study conducted to Pediatricians and Pediatrics Residents concerning the month of April of 2020. It was based on an anonymous and confidential survey applying a Likert Scale of 5 level points of agreement. Inferential and descriptive analysis resorting to SPSS®26 (p=0.05). Total of 113 respondents, 67% Pediatricians; 92% working in National Health Service (n=104). In 66% of the sample the reorganization was considerate adequate, with creation of protocols before the officials in 50%, team division in 48%, 60% turnover. The articulation with Public Health was possible (77%) and adequate (56%). Restructure and creation of circuits in 90%, physical division of all sectors in 67%, considered safe and adequate in 80%. Protection include training on Personal Protection Equipment (75%) and SARS-CoV-2 jab (47%). Personal Protection Equipment: complete 47%, rationing 70%, self-acquired 26%. In response to COVID-19, the adjustment of Pediatric Services showed a higher degree of adaptation and adequacy proportional to the availability of material and individualization of separated workspaces. The greatest deficiencies were found at the level of Personal Protection Equipment, namely with rationing or need for acquisition by professionals.
A rare and fatal cause of blisters in a newborn
Authors: Rua Inês , Vidal Marta , Calvão Joana , Castelo Rui , Ramos Leonor
Published: September 2023

Newborns may develop blisters and erosions due to multiple entities, including infections, congenital or hereditary diseases. In this report we describe a male newborn who presented with pustular lesions on the first day of life and progressively developed blisters and erosions. Due to disease progression even with intravenous antibiotic therapy after suspicion of bullous impetigo, other diagnoses had to be considered and a multidisciplinary approach with the support of dermatology was necessary. A skin biopsy and genetic study were performed, which allowed the definitive diagnosis of Epidermolysis Bullosa, a group of rare hereditary bullous diseases. Because of the absence of curative therapy, supportive treatment was performed, which did not prevent the patients death at 2 months of life. It is therefore essential for pediatricians to identify this entity as early as possible in order to improve the prognosis
EPIDEMIOLOGICAL PROFILE OF NEWBORNS WITH RETINOPATHY OF PREMATURITY AT THE UNIVERSITY HOSPITAL OF THE FEDERAL UNIVERSITY OF MARANHÃO
Authors: Branco Rebeca , Menezes Valéria , Avelar José Francisco , Vale Marynea , Marques Patrícia
Published: September 2023

Objective: To describe the profile of premature newborns and exploratory analysis of factors associated with the development of retinopathy of prematurity (ROP) at the University Hospital of the Federal University of Maranhão (HUUFMA). Methods: This is a cross-sectional study based on data from the medical records of premature newborns treated at the University Hospital of the Federal University of Maranhão (HU-UFMA), from 2015 to 2020. Possible statically significant associations for the development of ROP were evaluated: sex, gestational age, birth weight, length, head circumference, length of hospital stay, APGAR and others. The significance level adopted was 5% (p<0.05). Results: It was found that, in children with a confirmed diagnosis of ROP, the most prevalent sex was female (50.95%), the mean gestational age was 29.08 weeks, the most frequent outcome was hospital discharge (70, 71%), mean birth weight was 1,089 grams, mean hospital stay was 45.44 days, mean length was 35.73 cm, mean head circumference was 26.06, Apgar most prevalent in the first minute was in the range from 4 to 7 (43.32%) and in the fifth minute from 8 to 10 (56.40%). Conclusions: The prevalence of ROP cases was 61.40% among newborns followed up at a reference service in the state of Maranhão. It was observed that the lower the gestational age and birth weight, the greater the risk of developing ROP.
NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) IN PEDIATRIC PATIENTS WITH EXCESS WEIGHT - RETROSPECTIVE SINGLE CENTER STUDY
Authors: Vidal Carolina , Zaia Paula , Hashimoto Miriam
Published: September 2023

Objective: to assess the prevalence of non-alcoholic fatty liver disease (NAFLD) in a gr oup of overweight/obese pediatric patients; to evaluate which clinical, anthropometric a nd laboratory parameters differ between patients with and without NAFLD and to associ ate the alterations with the presence of NAFLD. Methods: retrospective observational st udy between 2012-2017, involving overweight/obese children and adolescents in 2 grou ps: WITH-NAFLD and WITHOUT-NAFLD. The presence of hepatic steatosis on ultraso und was considered for diagnosis of NAFLD. Studied variables: age, sex, systolic (SBP ) and diastolic (DBP) blood pressure, birth weight (BW), weight, height, body mass inde x (BMI), BMI Z-score, waist circumference (WC), fasting blood glucose, insulin, IR-HOM A, triglycerides, total cholesterol and fractions, transaminases (ALT and AST) and thyro id stimulating hormone (TSH). Statistical analysis using Chi-square and Mann-Whitney t ests for comparison between two groups; multivariate logistic regression analysis for as sociation with NAFLD; p<0.05. Results: 174 patients were evaluated, 35 WITH-NAFLD (20.1%). SBP>95th percentile (29 vs 14; p= 0.003), BMI (29.7 vs 27.5; p=0.010), BMI Z -score (3.2 vs 2.9; p=0.036), WC (93 vs 88.5; p=0.046), insulin (15.7 vs 12.8; p=0.028), Residência Pediátrica; 2023: Ahead of Print DOI: 10.25060/residpediatr-2023-925 Nota aos leitores: pode haver informações pendentes, por se tratar de um artigo em “visualização pré-publicação”. IR-HOMA (3.2 vs 2.5; p=0.028) and ALT (39 vs 27, p<0.001) were significantly higher in WITH-DHGNA group. The others parameters did not differ. ALT was the only associate d parameter with NAFLD (1.06; p=0.003) by multivariate logistic regression. Conclusion : one fifth of overweight/obese pediatric patients had NAFLD and had higher degrees of obesity, abdominal adiposity, insulin resistance and systolic pressure values. ALT was a ssociated with NAFLD.
Clinical, laboratorial and radiological aspects of patients admited with suspected pertussis
Authors: Lima Tereza , Maia Paula , Vasconcelos Gabriela , Bezerra Maria Luísa , Moura Maria Beatriz , Cardoso Yane , Castro Lucas , Silva Patrícia
Published: September 2023

Objective: Describe the profile of patients admitted with signs of pertussis, emphasizing the differences between confirmed cases and its differential diagnosis. Methods: Retrospective study realized by the analysis of medical charts of patients from 0 to 2 years old, admitted between 2015 to 2019 with suspected pertussis. Epidemiological, clinical, laboratorial, and radiological variables were verified. The data was analyzed descriptively and through associations. Results: 211 patients were included, being 81,1% levss than 6 months old and 49,3% male. At the admission, high frequency of coughing (99.1%), paroxysmal coughing (60,2%), cyanosis (78,7%) and dyspnea (70,1%) was observed. Data showed that 8,4% of the patients who underwent leukogram presented lymphocytic leukocytosis, and 57,5% of the patients submitted to chest X-ray presented abnormalities. The pertussis diagnosis was confirmed in only 37 patients. There was significative association (p<0,005) between pertussis and the variables: cyanosis, post-cough vomiting, inspiratory squeak, tachypnea, respiratory auscultation abnormalities and leukocytosis. Furthermore, 72,9% of the patients did not get the vaccine or the schedule was incomplete. Conclusions: The presentation of pertussis, in general, is similar to other respiratory infections, being fundamental the maintenance of the epidemiological surveillance to collaborate with the diagnosis, reduce use of macrolides and adequate the prophylactic measures.
Dependência em tecnologia
Authors: Picon Felipe Almeida , Landsberg Gabriel Bronstein
Published: September 2023

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Suicídio em dependentes químicos - setembro amarelo
Authors: Salgado Carlos Alberto Iglesias , Alves Hamer Nastasy Palhares , Campos Valdir Ribeiro
Published: September 2023

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The Role of Cognitive Metaphor in Chinese and Russian Languages
Authors: Xiuqing Chen
Published: September 2023

Communication refers to cognitive activity, therefore it is necessary to comprehensively investigate its individual aspects. The purpose of this article is to study the role of cognitive metaphor in Russian and Chinese. The subject of the study is cognitive metaphor in Russian and Chinese languages. The object of the study is the meaning of cognitive metaphor in Russian and Chinese. The author used methods of deduction and induction, comparative, contextual analysis. The author examines in detail the stages in the study of metaphor. Translation is a special act of retransmission in the form of international communication, in which the transfer of thoughts, feelings, and cultural experience is especially important. Through language it is possible to reflect the system of spiritual culture. The main content of the moral foundation of the Russian cultural tradition is the principles of Orthodoxy. Chinese traditions are based on a powerful moral experience, the basis of which are the ideas of Confucianism. The scientific novelty of the study consists in the analysis of specific examples of cognitive metaphors in the text materials of Chinese-Russian intercultural communication. The concept of metaphor is investigated, its characteristics in the cognitive approach are revealed. A metaphor is a universal sign that performs an epistemological function in the process of transmitting information. Cognitive metaphor allows you to know and describe the unknown through acquired experience, is a key element of the thought process. Cognitive metaphor is of great importance in economic and political international translations. Most concepts in the commercial sphere are multi-component and difficult to perceive. The specific examples of cognitive metaphors in the materials of Chinese-Russian intercultural communication are analyzed. Practical recommendations on the correct understanding and use of cognitive metaphors in the translation process are offered.
Culturological approach to the development of a general civil culture of Internet communications security
Authors: Bylevskiy Pavel Gennadievich
Published: September 2023

The problem solved in this article is to determine the possibilities and advantages of a culturological approach to solving the problem of developing a general civil culture of Internet communications security. The subject of the study is the structural and functional features of this culture, and the object is the evolution of the formation of the corresponding complex of beliefs, knowledge, skills and abilities. The topic of expanding from a highly professional to a general civil culture of Internet communications security is considered. The increase in the share and importance of socio-cultural aspects compared with technical factors is analyzed. Particular attention is paid to the substantive aspects of the general civil culture of Internet communications security: the insufficiency of methods for broadcasting rules and relevant examples to a mass audience, as well as the underestimation of the formation of intuitive caution, the ability to recognize threats in a timely manner and respond correctly to incidents. The novelty lies in the postulation of the high representativeness of the security culture of financial Internet services, due to the combination of the mass nature of civilian users and transactions with funds that are highly attractive to intruders. It was here that mass Internet crime was first formed, threats and methods of attacks and, accordingly, security tools evolved. The conclusion is made: the experience of countering "social engineering" in the field of mass financial services is useful as a basis for the formation and development of a general civil culture of Internet communications security, including socio-cultural threats: fake news, disinformation, destructive and prohibited content, and others.
Graphic and visual means of creating an individual author's style (based on the texts of Umberto Eco)
Authors: Tsygankova Alisa Andreevna
Published: September 2023

In this article, the author considers such means of creating an individual author's style as graphons and phonetic-graphic means. The subject of the study is both deviations from the norm, graphically designed, and purely graphic techniques subordinated to the idea of creating a language game. Among the phenomena considered by the author are italics, typeface variation, author's punctuation, capitalization, strikethrough, underlining, bold, solid writing, as well as special lettering of some characters. The research is based on the material of Umberto Eco's novel "Baudolino" and "Diario minimo". As the analysis has shown, Eco resorts to special character designs to create irony, as well as to enhance the expressiveness of the artistic text. The novelty of this study lies, first of all, in the choice of material that had previously remained outside the limits of linguistic research, as well as beyond the attention of domestic linguists. The novel "Baudolino" has hitherto been the subject of research exclusively among literary critics, semiotics and medievalists, but has not been considered from a linguistic point of view. The same can be said about humorous experiments of Umberto Eco. The theoretical significance of the research lies in attracting the attention of researchers to such means of creating an individual author's style as graphic and visual, based on the material of Umberto Eco's creative heritage.
Formation of a responsible attitude of the children of primary school age to their health
Authors: Livak Nataliya Stepanovna , Portnyagina Anastasiya Mikhailovna , Tkacheva Anna Vladimirovna , Popov Vitalii Vladimirovich , Vladykin Igor' Vil'yamsovich
Published: September 2023

Today, children's health problems need new approaches. In this regard, the educational function of teachers and psychologists is important in order to form a child's idea of a healthy lifestyle, to form right attitudes to their's own health. This is of particular importance for young people, children, since they are the future generation that will continue our history, which has determined the relevance of this work related to the formation of a responsible attitude to a healthy lifestyle of children, which is the subject of this work. A psychological and pedagogical program for 4th grade students has been developed to form a responsible attitude to their health and healthy lifestyle. The implementation of the program includes three main levels: 1) Emotional involvement (emotional-value component of a responsible attitude); 2) semantic (cognitive component); activity (activity component). As a result of the implementation of the psychological and pedagogical program, the level of responsible attitude of children to their health has significantly increased. Namely, the number of children with a conscious attitude to their health has increased (cognitive component), the level of mastery of cultural norms has increased (emotional and value component), the number of schoolchildren participating in health-preserving and promoting a healthy lifestyle has increased
Strategic planning in the sphere of education in regions
Authors: Koshkina E. N. , Bocharova I. E. , Orlova E. R. , Bannikov S. A.
Published: September 2023

The article is devoted to problems of strategic planning in education. Special attention is paid to the formation of regional education development programs. The article considers the main provisions of the strategic program for the development of the education system at the municipal level as a key position for the formation of a unified educational space. The authors’ analysis of such programs has shown that such programs are often devoid of consistency and are not consistent with the development programs of the leading branches of knowledge and the economy of the region. Based on the legal framework, scientific articles, and the experience of the regions the authors propose a model for the formation of regional strategic planning documents in the field of education, based on the principle of a triple helix of interaction between the state, educational organizations and business. The educational space planned according to this model will differ not only in a new organizational format designed to coordinate the path of education and training, but will also serve as a consolidation of resources from all three sources.
Tourism development in the North Caucasus Federal District
Authors: Stroev V. V. , Magomedov M. D. , Alekseycheva E. Yu.
Published: September 2023

The article shows the great importance of tourism development for the economy of the Russian Federation. Attention is drawn to the availability of favorable conditions for this industry in the North Caucasus Federal District of the country. The tourism development potential is considered in detail in each subject of the studied district (Stavropol Territory, the Republic of Dagestan, the Chechen Republic, the Republic of Ingushetia, the Kabardino-Balkarian Republic, the Karachayevo-Cherkessian Republic, The Republic of North Ossetia-Alania), and the circumstances hindering this process have been identified. The main directions of tourism development in the subjects of the North Caucasus Federal District are substantiated, such as growth of highly qualified specialists in tourism organization; construction of hotels; infrastructure development; increasing the number of catering facilities; improving the quality of transport services; conducting marketing research aimed at the tourism development of various directions; effective pricing policy for tourist services.
Satisfaction with the university lecturers’ work in the human resource tertiary education’s management system
Authors: Ilina I. Yu.
Published: September 2023

In the conditions of tertiary education’s modernization, the effective management’s importance of the personnel potential’s development of universities increases. One of the significant factors determining the success of management mechanisms in the tertiary education system is the satisfaction with the work of lecturers. The purpose of the study is to assess the level of satisfaction with the work of lecturers, to reveal the significance of its parameters in the management system of the tertiary education’s personnel potential. Based on empirical research data, the article analyzes the most important parameters of work at the university for lecturers and the realization level of the opportunities that work at the university provides. The segmentation author’s version of lecturers according to the level of job satisfaction is proposed, the use of which allows optimizing the process of making managerial decisions based on considering the characteristics of employees’ various segments. The work directions are highlighted on improving the management efficiency of the tertiary school’s personnel potential.
Abolishment of a tax on imputed income: consequences for business and budget
Authors: Zotikov N. Z.
Published: September 2023

The article purpose is to investigate changes of taxpayers in the simplified and patent taxation system, in the structure of tax revenues of regional and local budgets, in the tax burden on taxpayers that occurred in connection with the abolition of tax on imputed income (from 2021). The research used generally accepted methods of scientific cognition, such as analysis, synthesis, generalization, grouping, tabular method. The information base of the study was the Tax Code of the Russian Federation, official reporting data of the Federal Tax Service of Russian Federation, authors’ publications on the topic under study. The study obtained the following results. The tax revenues of local budgets decreased, having lost the source of income in the form of tax on imputed income, previously credited in full; the tax burden on taxpayers increased (when tax on imputed income was applied, it was minimal). The main conclusion of the study is the fact that the patent taxation system, which can be applied by entrepreneurs who have ceased to be payers of tax on imputed income, needs a radical transformation. It is necessary to improve the efficiency of such system in terms of determining the amount of income from which the cost of a patent is calculated.
Self-actualization and subjectivity in young men looking for a new job
Authors: Tsvetkova N. A.
Published: September 2023

The study subject is self-actualization and subjectivity in men looking for work. The purpose of this research is to identify the features of their self-actualization and subjectivity. Such methods of psychodiagnostics as the “SAT” technique by E. Shostrom (adapted by Yu.E. Aleshina et al.); the “URSL” test by M.A. Shchukina were used. Taking into account the main results of the study, the author came to the conclusion that the sample as a whole revealed problematic self-actualization and a fairly high overall level of subjectivity. In 83% of respondents, self-actualization was revealed only by contact. The proportion of men who recognize the values of a self-actualizing personality was 34%. A direct close connection between self-actualization and subjectivity has been established. The field of application of the found results is the social psychology of personality (the data received are important for assessing the socio-psychological readiness of men to promptly solve the problem of employment using intrapersonal resources). Mentioning the prospects of the study, it should be advisable to perform a comparative analysis of data by gender. The results obtained are valuable for practical social psychologists in terms of helping young men who find it difficult to realize their intentions to find a new job due to problematic self-actualization and insufficient subjectivity.
Project sustainability in the conditions of digitalization
Authors: Lubenets M. V. , Sycheva S. M.
Published: September 2023

The methodological basis of the study is fundamentals of the project sustainability concept, key principles and features of sustainable development, conceptual approaches to strategic sustainability of project activities. A content analysis of Russian and foreign literature was carried out to determine the current challenges of project implementation. The article uses general scientific methods of analysis, synthesis, generalization, decomposition of factors, as well as tabular and graphical visualization techniques of various categories. The results of the paper consist in clarifying the theoretical aspects of the projects’ sustainability and their constituent elements, in substantiating high level of uncertainty of various criteria for project implementation due to the significant turbulence of external factors and the emergence of new challenges, as well as in determining the need to transform established approaches to the sustainable development of projects. As a result of the research, a new approach has been developed to assess the sustainability of projects based on a strategic model that takes into account modern challenges of uncertainty and turbulence. The study prospects lie in practical use of developed integrated approach for models’ formation for the sustainable implementation of projects in various business areas.
Tools of information and communication technologies in the knowledge management system
Authors: Gorina I. G. , Fomenko N. M.
Published: September 2023

This article considers the knowledge management system as an element of the overall management system of the organization along with the processes of corporate culture and corporate education. The implementation of knowledge management system provides an increase in competitiveness, has a favorable effect on the intellectual potential of the organization, human resource management and innovations’ development. The means of information and communication technologies in the knowledge management system, in corporate training and in corporate culture are considered, and the connection between them is outlined. The use of Intranet and Extranet systems in the context of the collection, storage and use of organizational knowledge is analyzed. Corporate training issues from the point of view of increasing the operational efficiency of organizations are touched upon. Trends in the development of corporate culture are outlined, where a special role is played by the formation of a favorable environment for the knowledge transfer. The functioning of corporate education and corporate culture, in the aggregate, can increase the implementation effectiveness of knowledge management system.
Information flows’ movement analysis in the integrated accounting and analytical system of individual entrepreneurs in the web business on marketplaces sphere
Authors: Nepryahina T. M.
Published: September 2023

The annual increase in the number of individual entrepreneurs in comparison with the decrease in the number of legal entities, especially in the form of microbusiness in the field of online commerce on marketplaces, reflects the relevance of the chosen topic. The analysis of scientific articles over the past year confirms that research on the specifics of the individual entrepreneurs’ activities is aimed primarily at the external interaction of entrepreneurs and the state. The scope of internal control and the features of accounting for individual entrepreneurs have not been previously considered by scientists. Earlier in the works of scientists, business management processes, elements of a balanced scorecard system and stages of the accounting process were included for a simplified structure of an integrated accounting and analytical system. The study purpose is to optimize information flows in the accounting and analytical system of individual entrepreneurs in the field of web business on marketplaces. As a result of the study, the information movement has been clarified in order to fix indicators of strategic goals and the formation of tax accounting registers. The goals’ components and system’s objectives of balanced indicators for individual entrepreneurs have been formed, considering the specifics of web business on marketplaces. The tasks’ interrelation is reflected and the possible connection of universal indicators within the framework of strategic goals is described. These studies can be used as the development of state recommendations on accounting by individual entrepreneurs as an alternative to existing ones for organizations. Further studies may be devoted to assessing the effectiveness of the accounting and analytical system for individual entrepreneurs and clarifying the algorithm of automation, as well as obtaining information when accounting within such a system.
The methodology genesis of system-dynamic modeling and the prospects of its application to solve the corporate change management’s digitalization problems
Authors: Sokolov D. A.
Published: September 2023

The paper presents identification of the main directions and conceptual approaches of methodological support for corporate change management digitalization and improvement of organizations. Within the framework of the study, the prospects of applying the methodology of system-dynamic simulation modeling in the conditions of digital transformation of the economy and management are analyzed. The issues of mastering the areas of growth of the organization and carrying out economically justified transformations, implemented including through the investment management strategy, are investigated within the framework of system-dynamic modeling of economic systems proposed by J. Forrester. The use of such modeling has been carried out to improve organizational forms and increase the efficiency of organizations’ management. The article discusses the current problems and key tasks of digitalization of corporate governance using a systematic approach. The tendencies of improving the methodology of system-dynamic simulation modeling are investigated. The development scheme of the system-dynamic modeling’s stages presented in the classical literature on system dynamics is given. Variants of methodology development based on the synthesis of classical approaches with advanced corporate governance practices and current works of foreign, Russian researchers are proposed. Ultimately the synthesis proposed in the paper will make it possible to create models based on the synthesis of methodologies, and most effectively master the growth’s areas of organizations, as well as to carry out economically justified transformations implemented, including through an investment management strategy.
Mathematical model for the analysis of environmental risk factors
Authors: Sukhorukova I. V. , Chistyakova N. A.
Published: September 2023

The article studies the economic consequences of harmful effects on the environment. A mathematical model has been developed for the analysis of environmental risk factors. When constructing a model, the probability of an insured event depending on time is taken into account. It is shown that different probabilistic impact models can be used for different categories of risk factors. The development of a dynamic model is based on the methods of probability theory, actuarial mathematics and, accordingly, on the, numerical methods and simulation methods. Analytical expressions for the risk factor integral value of environmental management are obtained in the work. The mathematical calculation of the distribution function, or the survival function before the time period occurrence of an insured event in different cases is performed, namely: in the case of a risk factor with a constant intensity, in the case of gradually emerging risk factors with their constant intensities, in the case when the survival function is decreasing at a linear rate, as well as in the case when equipment wear and tear leads to an exponential increase in the risk intensity.
Labor mobility in the system of employment strategies of the region’s population
Authors: Kolesnik E. A. , Polovinko V. S.
Published: September 2023

The issue consideration of labor mobility as an employment strategy is relevant, because it is based on a growing understanding of the importance of labor mobility for the economic development of the country and its regions. The study purpose is to examine the place of labor mobility in the employment strategy of the population. The objectives are to study approaches to the labor mobility definition as an employment strategy, to analyze regional specifics in the labor mobility of the population, to determine the place of labor mobility in the employment strategy of the Tyumen region. General scientific, statistical and sociological methods were used in the research. The main study results are the identification of an increasing trend in the transformation of the population employment strategy and its reflection on the processes of labor mobility, grouped around changes in production and economic conditions. This provision defines not only the basis for the development of scientific discussion, but also the directions for further study of such issue.
A versatile “Synthesis Tag” (SynTag) for the chemical synthesis of aggregating peptides and proteins
Authors: Bürgisser Héloïse , Williams Elyse T. , Lescure Robin , Premanand Adhvitha , Jeandin Aliénor , Hartrampf Nina
Published: September 2023

Solid-phase peptide synthesis (SPPS) and native chemical ligation (NCL) are powerful methods for obtaining peptides and proteins that are otherwise inaccessible. Nonetheless, numerous sequences are difficult to prepare via SPPS, and cleaved peptides often have low solubility. To address these challenges, we developed a “Synthesis Tag” consisting of six arginines connected via cleavable MeDbz linker. “SynTag” effectively improves batch- and flow-SPPS of “difficult sequences”, enhances solubility of the cleaved peptides and provides direct access to native sequences by hydrolysis, or peptide thioesters for NCL.. We demonstrate its utility in the first chemical synthesis of the MYC transactivation domain (143 AA) with a single NCL. We envisage SynTag to become a broadly applicable tool that enables the synthesis and study of previously unattainable peptides and proteins.
Atlas: A Brain for Self-driving Laboratories
Authors: Hickman Riley , Sim Malcolm , Pablo-García Sergio , Woolhouse Ivan , Hao Han , Bao Zeqing , Bannigan Pauric , Allen Christine , Aldeghi Matteo , Aspuru-Guzik Alán
Published: September 2023

Self-driving laboratories (SDLs) are next-generation research and development platforms for closed-loop, autonomous experimentation that combine ideas from artificial intelligence, robotics, and high-performance computing. A critical component of SDLs is the decision-making algorithm used to prioritize experiments to be performed. This SDL “brain” often relies on optimization strategies that are guided by machine learning models, such as Bayesian optimization. However, the diversity of hardware constraints and scientific questions being tackled by SDLs require the availability of a set of flexible algorithms that have yet to be implemented in a single software tool. Here, we report Atlas, an application-agnostic Python library for Bayesian optimization that is specifically tailored to the needs of SDLs. Atlas provides facile access to state-of-the-art, model-based optimization algorithms—including mixed-parameter, multi-objective, constrained, robust, multi-fidelity, meta-learning, and molecular optimization—as an all-in-one tool that is expected to suit the majority of specialized SDL needs. After a brief description of its core capabilities, we demonstrate Atlas’ utility by optimizing the oxidation potential of metal complexes with an autonomous electrochemical experimentation platform. We expect Atlas to expand the breadth of design and discovery problems in the natural sciences that are immediately addressable with SDLs.
Virtual Variables-Enabled Generation of Datasets for Prediction in Organic Synthesis: Digitalization of Small Molecules and Its Application to Functional Molecule Syntheses
Authors: TAKEDA Kazuhiro , OHTSUKA Naoya , SUZUKI Toshiyasu , MOMIYAMA Norie
Published: September 2023

In machine learning, large datasets are typically required to improve estimation accuracy. However, the generation of such datasets in traditional organic synthesis experiments is extremely challenging. Hence, there is a strong demand for methods that enable the accurate prediction of outcomes using limited amounts of data. In this study, we report a molecular technology based on generative artificial intelligence that generates data from unexplored conditions and establishes the most suitable relationships between different small molecules using virtual variables. Specifically, our approach reveals relationship of structurally different three small molecules and represents them as virtual variables, which are then utilized to propose the reaction conditions for synthesizing target molecules in high yields. We demonstrated the utility of this approach in small molecule syntheses, using the iodination reaction of polyfluoronaphthalenes serving as a case study. The obtained iodinated perfluoronapthalenes have recently garnered significant attention as promising candidates for functional molecules. By computationally generating data that would be inaccessible through realistic reaction experiments, we successfully optimized reaction conditions in an additional 8 experiments. Moreover, we succeeded to depict virtual variables in electrostatic potentials using density functional theory calculations and represented them as physicochemical indices. This study introduces a novel application of machine learning as molecular technology and contributes small molecule syntheses in molecular science, utilizing fewer than 100 data points in the realm of organic synthesis experiments.
Atroposelective Chan-Evans-Lam Amination
Authors: Thönnißen Vinzenz , Westphäling Johannes , Atodiresei Iuliana , Patureau Frederic
Published: September 2023

The synthetic control of atropoisomerism along C─N bonds is a major challenge, and methods that allow C─N atroposelective bond formation are rare. This is a problem because each atropoisomer can feature starkly differentiated biological properties. Yet, among the three most practical and applicable classical amination methods available: 1) the Cu-catalyzed Ullmann-Goldberg reaction, 2) the Pd-catalyzed Buchwald-Hartwig reaction, and 3) the Cu-catalyzed Chan-Evans-Lam reaction, none has truly been rendered atroposelective at the newly formed C─N bond. The first ever Chan-Evans-Lam atroposelective amination is herein described with a simple copper catalyst and new PyrOx chiral ligand. This method constitutes a change of paradigm in the field.
SWAMNA: a comprehensive platform for analysis of nucleic acid modifications
Authors: Xie Yixuan , De Luna Vitorino Francisca N. , Chen Ye , Lempiäinen Joanna K. , Zhao Chenfeng , Steinbock Robert T. , Liu Xingyu , Lin Zongtao , Zahn Emily , Garcia Arabella L. , Weitzman Matthew D. , Garcia Benjamin A.
Published: September 2023

The interest in MS-based analysis of modified nucleic acids is increasing due to the application of nucleic acids in therapeutics. However, there are few available integrated platforms for characterizing nucleic acid modifications. Herein, we report a general mass spectrometry-based SWATH platform to identify and quantify both RNA and DNA modifications, which we call SWATH Analysis of Modified Nucleic Acids (SWAMNA). SWAMNA incorporates the search engine, NuMo Finder, enabling the analysis of modifications in native and permethylated form. SWAMNA will aid discoveries that provide new insights into nucleic acid modifications.
FROM TRADITIONAL TO MODERN FORMS OF CRISES – A BRIEF ANALYSIS OF HUMAN CRISES
Authors: Petrova Elitsa Stoyanova
Published: September 2023

This article presents the variety of types of crises in human society. The reader is briefly introduced to the essence and content of the concept of crisis, as well as the concept of the human security, which emphasizes that in addition to traditional security threats, the world nowadays faces a number of modern forms of global threats. The crises caused by military conflicts; crimes against humanity; usage of weapons of mass destruction; terrorism and organized crime; natural crises and environmental degradation; economic crises and poverty; social crises; health and infectious disease crises; crises caused by globalization and by a change in the value system and morality of people; political and governance crises are presented in more detail in order to fully achieve the informative goal of the article.
Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation
Authors: Soares Vinicius Cardoso , Dias Suelen Silva Gomes , Santos Julia Cunha , Azevedo-Quintanilha Isaclaudia G , Moreira Isabela Batista Gonçalves , Sacramento Carolina Q , Fintelman-Rodrigues Natalia , Temerozo Jairo R , da Silva Marcos Alexandre Nunes , Barreto-Vieira Debora Ferreira , Souza Thiago ML , Bozza Patricia T
Published: September 2023

SARS-CoV-2 induces major cellular lipid rearrangements, exploiting the host’s metabolic pathways to replicate. Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that control lipid metabolism. SREBP1 is associated with the regulation of fatty acids, whereas SREBP2 controls cholesterol metabolism, and both isoforms are associated with lipid droplet (LD) biogenesis. Here, we evaluated the effect of SREBP in a SARS-CoV-2–infected lung epithelial cell line (Calu-3). We showed that SARS-CoV-2 infection induced the activation of SREBP1 and SREBP2 and LD accumulation. Genetic knockdown of both SREBPs and pharmacological inhibition with the dual SREBP activation inhibitor fatostatin promote the inhibition of SARS-CoV-2 replication, cell death, and LD formation in Calu-3 cells. In addition, we demonstrated that SARS-CoV-2 induced inflammasome-dependent cell death by pyroptosis and release of IL-1β and IL-18, with activation of caspase-1, cleavage of gasdermin D1, was also reduced by SREBP inhibition. Collectively, our findings help to elucidate that SREBPs are crucial host factors required for viral replication and pathogenesis. These results indicate that SREBP is a host target for the development of antiviral strategies.
AI for the detection of neurological condition: Parkinson's disease & emotions
Authors: Abhishek Jain , Rohit Raja
Published: September 2023

Artificial Intelligence (AI) is widely applied by many researchers in the measurement and analysis of signals and images in clinical medicine and the biological sciences. The role of machine learning in processing biomedical signals and its applications in medicine and healthcare is huge, and it is now in a very advanced stage. Several types of biomedical signals have been analyzed by using Deep Learning (DL), Neural Networks (NN), and Artificial Intelligence on Electrocardiogram (ECG) and Electroencephalogram (EEG) signals by many researchers. Parkinson's disease (PD) is a neurodegenerative disorder that progresses over time and is characterized by rigidity, tremor, postural instability, and non-motor symptoms caused by the loss of dopaminergic neurons in the substantia nigra. This paper analyses the current state of the art of EEG analysis using AI techniques for Parkinson's disease detection and emotion detection.
The Federal Inland Revenue Service (FIRS), Tax Compliance and the Fight Against Corruption in Nigeria
Authors: Jooji Innocent , Oyekan Margaret , Momoh Zekeri , Onuh Samuel
Published: September 2023

Purpose: The study seeks to investigate has the FIRS done to improve tax compliance and understand the effects of FIRS reforms had on tax compliance and the fight against corruption in Nigeria's tax system.
 
Theoretical Framework: This study is situated within the context of Institutional Theory. The Federal Inland Revenue Service is a government institution saddled with the responsibility of collecting government internally generated revenue in Nigeria.
 
Design/Methodology/Approach: The design of the study is descriptive and historical research design. Data for this study were collected from secondary sources like textbooks, journal articles and internet sources while content analysis was used to analyse the data collected.
 
Findings: The findings of this study shows that FIRS has ratified a number of international agreements, including the Global Forum on Transparency and agreements to prevent double taxation. Additionally, it has established Base Erosion and Profit Shifting (BEPS), Exchange of Information, and started the tax amnesty. The FIRS has inter-agency relationships with governmental organisations including the EFCC and ICPC, among others. In addition, the FIRS's efforts have resulted in a surge in annual tax payments; in 2018, it collected N5,320 trillion, the most in its history since the FIRS was founded. Additionally, the FIRS noted a decline in the cost of revenue collection from 2.6% in 2016 to 2.49% in 2017 and 2.14% in 2018.
 
Conclusion: Federal Inland Revenue Service (FIRS) should expand its campaign to rural areas where there is little to no tax education in order to increase its enlightenment mechanisms on tax compliance. This can be done by having the FIRS educate traditional leaders on tax compliance, who will then inform the populace.