bluuebunny/crossref_metadata_2025 huggingface dataset:
Adiponectin Alleviates Diet-induced Inflammation in the Liver by Suppressing MCP-1 Expression and Macrophage Infiltration
Authors: Ryu Jiyoon , Hadley Jason T. , Li Zhi , Dong Feng , Xu Huan , Xin Xiaoban , Zhang Ye , Chen Cang , Li Senlin , Guo Xiaoning , Zhao Jared L. , Leach Robin J. , Abdul-Ghani Muhammad A. , DeFronzo Ralph A. , Kamat Amrita , Liu Feng , Dong Lily Q.
Published: March 2021

Adiponectin
is an adipokine that exerts insulin sensitizing and anti-inflammatory roles in
insulin target tissues including liver. While the insulin sensitizing function
of adiponectin has been extensively investigated, the precise mechanism by
which adiponectin alleviates diet-induced hepatic inflammation remains elusive. Here, we report that
hepatocyte-specific knockout of the adaptor protein APPL2 enhanced adiponectin sensitivity
and prevented mice from high fat diet-induced inflammation, insulin resistance,
and glucose intolerance, although it caused fatty liver. The improved anti-inflammatory and insulin
sensitizing effects in the APPL2 hepatocyte-specific knockout mice were largely
reversed by knocking out adiponectin. Mechanistically, hepatocyte APPL2
deficiency enhances adiponectin signaling in the liver, which blocks TNF-a-stimulated MCP-1 expression
via inhibiting the mTORC1 signaling pathway, leading to reduced macrophage
infiltration and thus reduced inflammation in the liver. Taken together, our study
uncovers a mechanism underlying the anti-inflammatory role of adiponectin in the
liver and reveals the hepatic APPL2-mTORC1-MCP-1 axis as a potential target for
treating overnutrition-induced inflammation in the liver.
Peningkatan Hasil Belajar Materi Pecahan dengan Menerapkan Model Problem Based Learning dengan Media Manipulatif
Authors: Anjani Norma Dewi , Sulianto Joko , Untari Mei Fita Asri
Published: March 2021

Penelitian ini bertujuan untuk meningkatkan hasil belajar dan ketercapaian ketuntasan belajar siswa pada Materi Pecahan dengan menerapkan model Problem Based Learning dengan media manipulatif pada kelas V Sekolah Dasar Negeri 2 Jono Kecamatan Tawangharjo Tahun 2020/2021. Penelitian ini termasuk penelitian tindakan kelas. Seluruh siswa kelas V di SDN 2 Jono merupakan subyek dari penelitian ini. Pengumpulan data menggunakan metode tes, nontes dan dokumentasi. Instrumen yang digunakan berupa tes tertulis essai. Data yang didapatkan akan dianalisis dengan teknik perbandingan. Hasil penelitian menunjukkan bahwa (1) peningkatan hasil belajar siswa menggunakan model Problem Based Learning dengan media manipulatif terbukti dari hasil evaluasi prasiklus 13,79% meningkat pada siklus I menjadi 62,07%, kemudian pada siklus II meningkat menjadi 86,21%. (2) peningkatan ketercapaian ketuntasan belajar siswa menggunakan model Problem Based Learning dengan media manipulatif terbukti dari hasil evaluasi dari prasiklus hanya 4 siswa yang tuntas, meningkat pada siklus I menjadi 18 siswa yang tuntas, kemudian pada siklus II meningkat menjadi 25 siswa yang tuntas.
Penerapan Model Pembelajaran Kooperatif Co–Op Co-Op untuk Meningkatkan Prestasi Belajar Yadnya Secara Online
Authors: Suartina Gede
Published: March 2021

Penelitian ini dilaksanakan di SMK Negeri 2 Singaraja di Kelas X Kuliner 4 yang kemampuan siswanya untuk materi Yadnya pada mata pelajaran Agama Hindu dan Budi Pekerti tergolong rendah. Tujuan penulisan penelitian tindakan kelas ini adalah untuk mengetahui apakah model pembelajaran Kooperatif Co-Op Co-Op dapat meningkatkan prestasi belajar siswa. Metode pengumpulan datanya adalah tes prestasi belajar. Metode analisis datanya adalah deskriptif kuantitatif. Hasil yang diperoleh dari penelitian ini adalah model pembelajaran Co-Op Co-Op dapat meningkatkan prestasi belajar siswa. Ini terbukti dari hasil yang diperoleh pada awalnya dengan nilai rata-rata 68,44, pada siklus I menjadi 71,56 dan pada siklus II menjadi 81,09 dan ketuntasan belajar pada awalnya dengan ketuntasan 59,38%, pada siklus I menjadi 68,75% dan pada siklus II menjadi 96,88%. Kesimpulan yang diperoleh dari penelitian ini adalah model pembelajaran Kooperatif Co-Op Co-Opdapat meningkatkan prestasi belajar Siswa SMK N 2 Singaraja Kelas X Kuliner 4 Tahun 2020/2021 Semester Ganjil.
The Impact of Foreign Direct Investment on Economic Diversification: The Case of the Republic of Congo
Authors: Anaclet Jean , Ngouembe Lauric , Domba Biongo Grâce Fleurbellia
Published: March 2021

The objective of this work is to examine the effects of foreign direct investment on the diversification of the Congolese economy. The estimation results from the ARDL process, spanning the period 1995 to 2016, showed that FDI is a means of diversifying the Congolese economy in the short term. In the long term however, FDI is not a sufficient factor for the diversification of the Congolese economy. Thus, this research has revealed the importance of integrating political stability given that the effects of FDI on diversification also depend on the quality of the institutions.
Türkiye’de Fındığın Tarım Turizmi (Agro Turizm) İçindeki Yeri, Önemi ve Turizme Katım Çabaları Hakkında Bir Alan Araştırması
Authors: Kıngır Said , Şeyhanlıoğlu Hasan Önal , Gör Rıdvan
Published: March 2021

Son yıllarda kent yaşamından bunalan ve doğaya özlem duyan insanlar için turizm seçeneklerine yenileri eklenmiştir. Kırsal turizm olarak adlandırılan bu yeni turizm şekli ülkemiz için yeni keşfedilen ve gelecek vaat eden turizm seçeneğidir. Tarım (agro) turizmi ise Kırsal turizmin bir koludur. Bu çalışmada Sakarya ili Kocaali ilçesi Yalpankaya mahallesindeki fındık eksperlerinin fındık turizmi hakkındaki eğilimleri incelenmiştir. Yalpankaya mahallesinde faaliyet gösteren turizm hakkında bilgi sahibi olan yirmi altı fındık eksperi araştırmanın örneklemini oluşturmuştur. Nitel araştırma yönteminin tercih edildiği çalışmada, veriler yarı yapılandırılmış mülakat tekniği ile toplanmıştır. Araştırmanın sonucunda fındık üreticilerinin fındığın tanıtımı ve pazarlaması konusunda eksiklikler olduğu ve fındığa gerekli önemin verilmediği beyanında bulunmuşlardır. Bu nedenle araştırmaya katılanların esas gelir kaynakları fındık olmasına rağmen ikinci bir işle uğraştıkları görülmüştür. Tüm katılımcılar fındığın turizme kazandırılmasının faydalarına olacağı ve fındık turizmi ile alakalı projelere destek eğiliminde oldukları tespit edilmiştir.
Türk Otellerinde Kurumsallaşmanın İş Tatmini, Açıkça Konuşma ve İşten Ayrılma Niyetine Etkisi
Authors: Duran Alper , Unur Kamil
Published: March 2021

Araştırmanın amacı; otel işletmelerinin kurumsallaşma düzeyleri ile çalışanlarının iş tatmin düzeyleri, açıkça konuşma istekleri ve işten ayrılma niyetleri arasındaki ilişkinin belirlenmesidir. İlişkisel tarama modelinde tasarlanan araştırmada kullanılan veriler Antalya ve İstanbul’da yer alan beş yıldızlı otel çalışanlarından tabakalı örnekleme modeline göre toplanan 877 anket aracılığıyla elde edilmiştir. Veriler açıklayıcı, doğrulayıcı faktör analizi ve yapısal eşitlik modellemesi ile analiz edilmiştir. Bulgulara göre kurumsallaşma profesyonelleşme, tutarlılık ve formelleşme olarak 3 boyut, iş tatmini içsel ve dışsal olarak 2 boyut altında toplanırken, açıkça konuşma isteği ve işten ayrılma niyeti tek boyut altında toplanmıştır. Çalışmada, kurumsallaşma düzeyinin tüm boyutlarının dışsal iş tatmini üzerinde; tutarlılık ve formelleşme boyutlarının içsel iş tatmini ve açıkça konuşma isteği üzerinde olumlu ve anlamlı; profesyonelleşme boyutunun işten ayrılma niyeti üzerinde olumsuz ve anlamlı etkisi olduğu tespit edilmiştir.
PENGARUH CITRA MEREK TERHADAP KEPUTUSAN PEMBELIAN PADA PT.ASTRA INTERNATIONAL, Tbk TOYOTA AUTO 2000 BUMI SERPONG DAMAI
Authors: Manik Cornelia Dumarya
Published: March 2021

Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh citra merek terhadap keputusan pembelian pada PT. Astra International, Tbk-Toyota Auto 2000 cabang Bumi Serpong Damai. Penelitian ini dilaksanakan di PT. Astra International, Tbk-Toyota Auto 2000 cabang Bumi Srpong Damai. Model penelitian yang digunakan yakni dengan metode observasi, wawancara, kuesioner dan studi kepustakaan yang dilakukan secara sistematik berdasarkan tujuan penelitian. Metode penelitian ini menggunakan metode kuantitatif, asosiatif dengan populasi dalam penelitian ini adalah pelanggan yang melakukan service berkala pada PT. Astra International, Tbk-Toyota Auto 2000 cabang Bumi Serpong Damai, dalam waktu 5 (lima) tahun yaitu sebanyak 624 pelanggan. Metode penarikan sampel menggunakan rumus Slovin didapat sebanyak 86 responden. Metode analisis dalam pengolahan data adalah uji validitas dan reliabilitas, uji regresi linear sederhana, koefisien determinasi, uji hipotesis (uji-t), dan uji korelasi pearson product moment untuk mengetahui seberapa besar pengaruh citra merek terhadap keputusan pembelian mobil Toyota Yaris. Berdasarkan hasil penelitian dan pembahasan diperoleh hasil, bahwa terdapat pengaruh hubungan positif antara citra merek terhadap keputusan pembelian sebesar 0,602 sehingga adanya hubungan antara citra merek terhadap keputusan pembelian, dari hasil regresi lienar sederhana dapat dilihat persamaan yang bernilai y=16.546+0,583X. Yang memiliki arti bahwa variabel citra merek berpengaruh positif terhadap keputusan pembelian konsumen, dari hasil uji determinasi sebesar 0,362. Hal ini menunjukkan bahwa sebesar 36,2% Keputusan Pembelian konsumen terhadap pembelian mobil Toyota Yaris dipengaruhi oleh variasi dari ketiga variabel independen, yaitu keunggulan asosiasi merek, kekuatan asosiasi merek, keunikan asosiasi merek, Sedangkam sisanya sebesar 63,8% dipengaruhi oleh variabel-variabel lainnya yang tidak diteliti. Hasil t hitung adalah 6,907 lebih besar dari t tabel yaitu 1,9886. Oleh karena itu t-hitung lebih kecil daripada t-tabel, maka H0 ditolak dan Ha≠0 diterima. Ini menunjukkan bahwa antara pengaruh citra merek terhadap keputusan pembelian terdapat pengaruh yang signifikan.
PENGARUH PELATIHAN TERHADAP KINERJA KARYAWAN PADA PT. ELECTRONIC CITY CABANG BSD TANGERANG
Authors: Wardani Endang Susilo
Published: March 2021

Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan terhadap kinerja karyawan pada PT. Electronick City Cabang BSD Tangerang. Metode yang digunakan adalah explanatory research dengan sampel sebanyak 52 responden. Teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis. Hasil penelitian ini variabel pelatihan diperoleh nilai rata-rata skor sebesar 3,787 dengan kriteria baik. Variabel kinerja karyawan diperoleh nilai rata-rata skor sebesar 3,825 dengan kriteria baik. Pelatihan berpengaruh positif dan signifikan terhadap kinerja karyawan dengan nilai persamaan regresi Y = 13,866 + 0,644X, dan nilai koefisien korelasi 0,771 atau memiliki tingkat hubungan yang kuat dengan nilai determinasi 59,5%. Uji  hipotesis diperoleh signifikansi 0,000 < 0,05.
KONTRIBUSI TINGKAT RELIGIUSITAS DAN PROMOSI TERHADAP MINAT MASYARAKAT MENJADI NASABAH
Authors: Sjahruddin Herman , Ardiansyah Resky , Themba Orfiyanni Syarfetti , Tenriola Andi
Published: March 2021

Penelitian ini bertujuan untuk menguji kontribusi tingkat religiusitas dan promosi terhadap minat masyarakat menjadi nasabah. Populasi dalam penelitian ini adalah Nasabah PT. Bank BNI Syariah (Persero) Tbk Cabang Makassar. Jumlah sampel sebanyak 49 yang diperoleh dengan menggunakan Nonprobability sampling. Untuk mencapai tujuan dalam penelitian ini menggunakan metode analisis regresi linier berganda SPSS Ver. 22. Nilai t-statistik memberikan bukti jika tingkat religiusitas yang dimiliki nasabah dan promosi yang dilakukan pihak manajemen bank  terbukti memberikan kontribusi yang positif dan signifikan terhadap peningkatan minat masyarakat menjadi nasabah.
Concept of achieving maximum synergistic effect in production
Authors: Mukhin Aleksandr Vasilievich , Larionov Valery Glebovich , Ganina Galina Eduardovna , Ostrovskij Yuri Andreevich , Yakovleva Anna Petrovna
Published: March 2021

The article considers a concept of achieving the maximum synergistic effect in production on the basis of a new organizational form of cooperative activity, which allows to purposefully obtain an emergent result. There is a problem of measuring the synergistic effectiveness, which is explained by the variety of ways to assess the synergistic effect in general and in individual areas of human activity. Creativity in production activities, associated with intuitive thinking, can manifest itself in the form of global innovations, which differ in scale in time and in the degree of distribution in the areas of production, and have methodological significance for the laws of management in this activity. There have been discussed several global innovations in the field of process management to achieve production efficiency (division of labor; in-line production; flexible automated production; virtual production) with the division of labor. These global innovations are not connected to each other in a formal way and are the result of human creative activity based on intuitive thinking. The division of labor simultaneously leads to cooperation. The pattern of routine-creative transformation allows us to describe a new form of labor organization based on the so-called ergodynamic cooperative, the peculiarity of the structure of which is that cooperative activity has an integral part that provides a synergistic effect. There appears an inverse method of achieving emergence, from developing the emergence of the emergence property due to the inventive activity of the creative subject to the realization of this property in the product due to the cooperative activity of the cooperative participants. It is formally proved that the ergodynamic cooperative is an emergent-producing system that functions within the traditional paradigm of production efficiency, that is, belongs to global innovations.
Lo fantástico como palimpsesto. Lecturas sobre el cómic «Parque Chas»
Authors: Trabado Cabado José Manuel
Published: March 2021

Muchos estudiosos han definido de forma precisa “lo fantástico”. Este artículo pretende, sin embargo, atender a un aspecto que, quizás, no ha sido estudiado de forma tan profunda: su función en una relación dialógica con otros muchos géneros como la novela negra, la leyenda urbana, la ciencia ficción o el thriller considerados todos como mecanismos narrativos que permiten aludir de forma indirecta a hechos traumáticos. Todo ello puede ejemplificarse a través de una lectura a pie de texto del cómic argentino titulado Parque Chas de Barreiro y Risso publicado en la revista de cómics Fierro.
The Impact on Economic and Environmental Development of COVID-19 Pandemic: a Case Study in Indonesia
Authors: Dewi Nur Indriani , Melati Fadilla Citra
Published: March 2021

The goal of this analysis is to examine in greater detail the effect of the COVID-19 pandemic on economic development and the quality of the atmosphere in Indonesia. This report uses secondary data as the primary source, obtained using a secondary data collection method from many different organizations. Different government policies and measures to discourage the escalation of the transmission of the Coronavirus, one of which is large-scale social restrictions (PSBB). However, before Indonesia suffered a recession, the PSBB actually became a barrier to economic development. As a part of this program, the rise in environmental efficiency is another positive effect because traffic that generates emissions and vast manufacturing sectors that create dirty waste is temporarily halted. Based on the findings of the review, this report notes that there is a detrimental effect of COVID-19 on economic development in Indonesia. However, because of the introduction of PSBB, Indonesia's air quality has improved. This report is intended to serve as a reference and assessment of the effects of COVID-19 on the economy and the atmosphere for stakeholders and the general public. In order to allow the government to consider measures that will deter the spread of the coronavirus and restore the economy without damaging improved air quality.
Comportamiento de niños con Trastorno del Espectro Autista (TEA) en el uso de sus funciones ejecutivas suscitadas a partir de interacciones cognitivas con un robot humanoide
Authors:   , Palacios Villavicencio María de la Luz
Published: March 2021

Los niños con Trastorno del Espectro Autista (TEA) presentan primordialmente tres tipos de problemas: 1) patrones de comportamiento como actividades e intereses repetitivos y restringidos; 2) deterioro de la comunicación e interacción social, y 3) deterioro en la flexibilidad de pensamiento (DSM-5). La exploración diagnóstica ha estado mediada por aspectos empíricos, teóricos, metodológicos o epistemológicos. Analizados desde distintas áreas del conocimiento, a través de las cuales se han propuesto diversos tipos de intervenciones. Las explicaciones teóricas más importantes del comportamiento dentro del TEA han enfatizado la falta de interacción social de los niños con otras personas debido a: 1) un deficiente sistema de interpretación de las intenciones y del estado mental de otras personas; 2) la carencia de la optimización de sus funciones ejecutivas (FE) relacionadas con la capacidad para mantener una disposición adecuada durante la solución de problemas a largo plazo, y 3) deficiente adaptación social en relación con la falta de empatía, debido a una alta recurrencia de patrones detectados como las actividades e intereses restringidos y repetitivos. El objetivo que se cumple en la investigación es: describir, visualizar y analizar el comportamiento de niños con TEA mientras interactúan con un robot humanoide empleado como vehículo de interacción asistida para generar un modelo de interacción cognitiva. También ha sido importante evaluar su flexibilidad adaptativa a partir del empleo de sus FE asociadas a un nivel de consciencia. Se consideró la inclusión del robot humanoide debido a la alta aceptación que ha tenido entre los niños, incluyendo a los del espectro autista. A través del robot se desarrollaron tareas para ejercitar algunas de sus FE asociadas a los niveles de consciencia. Se empleó una metodología propia transdisciplinaria con el fin de: 1) explorar, 2) visualizar, y 3) analizar la conducta de los niños bajo condiciones experimentales, con el fin de establecer un modelo de interacción cognitivo. El modelo como resultado de la tesis se pone a prueba con niños con TEA y se sustenta en la alta capacidad de logro de las tareas e intereses que alcanzan los infantes durante las interacciones.
PENERAPAN PSAK NO. 45 DALAM PELAPORAN KEUANGAN PANTI ASUHAN YAYASAN ISLAM MEDIA KASIH TAHUN 2017
Authors: Wiladatika Wiladatika , Diantimala Yossi
Published: March 2021

There are lots of non-profit organization needs transparency and accountability in financial reports to engage donors to donate in Indonesia today. To support them, Ikatan Akuntan Indonesia has produced PSAK No. 45 about non-profit organization financial reports. This research placed in Yayasan Islam Media Kasih orphanage that has been one of non-profit organizations. The aim of this research is to identify whether the orphanage has applied PSAK No. 45 in their financial reports. Descripive research methods with qualitative analysis techniques outlines, describe and compare the data. The results showed they not match with the arranging of financial reports based on PSAK No. 45 formats. There are just revenue reports, expense reports, and balance sheets based form their own understanding. The Orphanage does not provide yet the reports o financial position, activity reports, cash flow reports, and the record of financial reports. Preferably, the orphanage provides the financial reports based on PSAK No. 45 to be more transparent and accountable so as to engage the donors.
Assessing the susceptibility of some gut bacteria to the extract from needles of Turkish pine
Authors: DEMİRTAŞ Ahu
Published: March 2021

Plant extracts have the potential to be safe alternatives to antibiotics that disrupt the gut flora. The aim of the present study was to assess the susceptibility of some gut bacteria to the extract from needles of Turkish pine (Pinus brutia Ten.) using microdilution method in an anaerobic chamber. Turkish pine needle extract promoted the growth of Bifidobacterium bifidum, Bifidobacterium infantis, and Lactobacillus acidophilus from gut commensals at 0.2-6.25 mg/mL, 0.4-6.25 mg/mL, and 0.4-1.6 mg/mL dose ranges, respectively (P
ПРОЯВ КРАЙОВОГО ЕФЕКТУ В СТРУКТУРІ ЗАРОСТЕЙ МАКРОФІТІВ ПРИ ЗМІНІ ГІДРОЛОГІЧНОГО РЕЖИМУ
Authors: Pohorielova M.
Published: March 2021

This paper considers the changes in the structural characteristics and macrophyte underwood species diversity of the Kiliya Danube Delta as a detection of the edge effect when the environmental conditions are changing. A total of 27 species of water vascular plants were identified. Moreover, filamentous algae were found but their species and genus were not determined. Biodiversity changes were evaluated using the Shannon Index which integrates species richness and their uniformity in the group. The significance of the results was assessed by testing the null hypothesis which is to verify the absence of changes in the average values of the sample using the Student's t test. Transitional watercourses (channels) have the highest indicators of information diversity where the manifestation of the edge effect is more distinct. There were statistically significant differences between the Shannon index in the end of the branch and the channel, as well as between the channel and the beginning of the water body, at the level of p = 0.05 which indicates the strength of the edge effect in the sample. It is established that the edge effect is reliably displayed in the transition from lotic (delta branches) to lentic conditions (non-flowing reservoirs – "corners"). It is displayed in the form of increasing biological diversity, decreasing in the role of monodominant groups and also in increasing floating pleistophytes quantity. Also in the channels which connect a flowing stream and waterbody is the highest species diversity and the highest Shannon index. Under lotic conditions even in the places of branch ramification and at different distances from such branches, the manifestation of the edge effect is not statistically proven. Therefore, we cannot prove the existence of edge effect in these objects despite the fact that we observe a tendency to increase species diversity at the beginning and end of the watercourse. The ecological structure of macrophyte groups is practically unchanged within each individual watercourse along its entire length. The Ochakivsky branch is dominated by groups of high-grass helophytes and floating pleistophytes, in Starostambulsky by groups of high-grass helophytes and rooted gidatophytes, and in the Vodtochny by low-grass gelophytes and floating pleistophytes.
ПЛАТАН КЛЕНОЛИСТИЙ (PLATANUS ACERIFOLIA WILLD.) В УМОВАХ МІСТ СТЕПОВОЇ ЗОНИ УКРАЇНИ
Authors: Zahorulko А. O. , Korshykov I. I.
Published: March 2021

For steppe cities, it is important to replenish the range with durable decorative species that grow quickly and form a three-dimensional crown. Such plants due to the shading of large areas create more comfortable living conditions for people in steppe cities. These species include London planetree (Platanus acerifolia Willd.), which sporadically began to be planted in some cities in the postwar period. The viability of P. acerifolia in the steppe is different. Since the biological peculiarities of this introduced species have been studied in various socio-economic problems in cities, we conducted a comparative analysis of the vital state and biometric parameters of P. acerifolia in the plantations of two cities of the steppe zone of Ukraine. We found out that P. acerifolia is widely used in landscaping of Kherson, while in Kryvyi Rih it is rare. In Kherson, the species is distributed near administrative buildings, schools, hospitals; it grows in parks, squares and yards of high-rise buildings, and in Kryvyi Rih only in one subdistrict and in the arboretum of the Kryvyi Rih Botanical Garden. The trees in Kherson are aged 38–60. The vital state is estimated as high and close to high – 77.8–96.3%. Older trees are 18.4–21.5 m of height and a maximum trunk diameter is 80.1–99.4 cm. Plants of all plantations in Kherson have dry branches, with a rate of 6.3–28.7%. In Kryvyi Rih, 28–42-year-old trees grow. In different plantations of P. acerifolia, the number of dry branches varies in the range of 0.3–44.5%, and the vital state – from 55.5 to 100% depending on the place of growth. The height of P. acerifolia trees is 6.2–20.3 m, and the trunk diameter is 12.2–68.7 cm. The study has proved that the differences in vital state and morphometric parameters of trees in the plantations of these cities depend on the age of trees, their planting density, lighting and other growing conditions. Trees in Kryvyi Rih are more significantly damaged by cold winds than in Kherson.

The life form of P. acerifolia in the plantations of Kherson and Kryvyi Rih is almost everywhere a single-stemmed tree. This species is beginning to naturalize in the conditions of Kherson. Several plants of self-seeding origin were found during the research studies. Restoration of plants with young sprouts produced by stumps after cutting the plant trunks in Kherson was also noticed. The leaf apparatus of plants during the growing season is practically not damaged by diseases and pests and no slimy stains are formed on the leaves.

We determined that P. acerifolia is a promising species for wider use in landscaping of the cities of the Black Sea coast and settlements of the Right-Bank Steppe, but in the latter case requires successful selection of exhibition sites for successful growth. These, first of all, should be cozy places protected from the effects of cold winds in winter and dry winds in spring and summer.
КОМБІНОВАНА ДІЯ НИЗЬКОЇ КОНЦЕНТРАЦІЇ РАУНДАПУ НА ДВОСТУЛКОВОГО МОЛЮСКА АКТИВУЄ ТІОЛОВІ СПОЛУКИ У ТРАВНІЙ ЗАЛОЗІ
Authors: Khoma V. , Gnatyshyna L. , Martinyuk V. , Mackiv T. , Yunko K. , Formanchuk R. , Baranovskii V. , Gladyuk M. , Manusadžianas L. , Stoliar O.
Published: March 2021

Glyphosate is one of most popular weed killers in the word. Its toxicity to aquatic organisms was investigated mostly in the acute high experimental exposures. The aim of this study was to evaluate the effect of low, 0.5 of Predicted No Effect Concentration (PNEC), of glyphosate in the combinations to freshwater bivalve mollusks.We treated the mussels Unio tumidus with glyphosatebased herbicide RoundupMAX (Rn, correspondent to 16.9 µg L-1 or 40 nM of glyphosate) in the combination with heating 25o C (RnT) or chlorpromazine (RnCpz, 18.0 µg L-1 or 56 nM of Cpz) and Cpz alone during 14 days. The responses of oxidative stress were evaluated in the digestive gland. The enzyme activities were changed only by the exposures to Rn (increase of superoxide dismutase) and Cpz (decrease of catalase), whereas the elevation of total glutathione (GSH) level was indicated in all exposures except Rn, and metallothonein-associated thiols (MTSH) – in all exposures except Cpz. Lipid peroxidation was increased in all exposures by 16.6% maximally. Total balance of antioxidants versus prooxidative changes was increased in all exposures contained Rn (by ~3 times in RnT-group) and decreased in the exposure to Cpz alone. Metallothionein chromatographyc features did not indicate substantial oxidative changes in all exposed groups. Hence, combine exposures distort prominently the oxidative stress responses to xenobiotics in the freshwater mussels even in low, nanomolar concentrations. The ability of Rn to induce MTSH seems to be the decisive input in the antioxidant defence at combine exposures.
MEASURING CHAIN FOR CHECKING THE VIBRATION OF MECHANICAL PARTS
Authors: Marcinko Peter , Hajduk Mikulas , Kočan Martin
Published: March 2021

Urgency of the research. Interest in this topic is aroused, because mechanical vibration may damage the machinery or parts of machine. Therefore, it is appropriate to design systems that detect problems. Also these systems can help in the timely replacement of the worn part. Target setting. The main goal is to design a system that can detect in a timely manner a problem that could destroy the device. It is therefore necessary to design systems that can record this. Actual scientific researches and issues analysis. In recent years, there has been an increase in demand for equipment that can
detect a timely problem. Many such devices already exist and are still being upgraded. This industry is called vibrodiagnostics. Uninvestigated parts of general matters defining. This paper is focused on the analysis of mechanical systems and the
creation of a measuring chain. The research objective. The aim of this research is to analyse the mechanical systems and the assembly of the measuring chain. The functionality of the device can be verified on this measuring chain. Whether or not it is suitable for operation. In the future these systems will be upgraded with software that better records the vibrations. The statement of basic materials. The analysis consists of basic information about mechanical systems and sensors. The definition
of this problem is described below. Based on this knowledge of mechanical systems, a measurement chain was designed. Conclusions. Our vision is to implement knowledge of mechanical systems not only on a simple fan stator. Problems of vibrodiagnostics
are still progressing and increasingly in technical practice. We would continue to do more testing on more complex devices.
DESIGN OF A CONTROLLER FOR IDEAL POSITIONING SERVOSYSTEM
Authors: Mikova Lubica
Published: March 2021

Urgency of the research. In advanced mechatronics, motion systems are the key technology, since mechanical systems such as Microelectronics manufacturing equipments are often required for high speed and accuracy. As a result, the increasing
influence of the dynamics of the mechanical system on the quality of the position servosystem is noticeable. One of the important dynamic effects is the dynamics of the mechatronic system's vibroisolation, which arises as a result of the reaction force generated by the action variable. Target setting. The aim of the paper was to design a PID controller for an ideal positioning servosystem. Ideal positioning servosystem consists of a one mass which is actuated by the Fservo force. Actual scientific researches and issues analysis. In modern controllers, in the correction error value, classic feedback combines with forwarding feedback. The forward control is based on the fact that if the model of the mechanical actuator is known and all the initial conditions are zero, the desired position can be reached without the use of feedback.
Uninvestigated parts of general matters defining. From a theoretical point of view, it has been devoted to ideal positioning servosystem for quite a long time, but the results achieved are rarely used in practice. One of the reasons is their theoretical focus, using complex mathematics, and as a result there is a great gap between theory and engineering practice. The research objective. Design of PID controller is based on equation for crossover frequencies, which allows to determine the derivative and integration constant of a PID controller for a given bandwidth. The statement of basic materials. The most important dynamic effects that impact the properties of actuators are actuator flexibility, flexibility of system limited mass and rigidity of the stationary part of the system. From the equation for the eigenfrequency ωDP of the low-pass second order filter is determined. Finally, the specific gain P is determined to suit the amplitude and phase margin. This completes the design of the ideal positioning servosystem.
Conclusions. PID controller for an ideal positioning servosystem is design based on equation for crossover frequencies, which allows to determine the derivative and integration constant of a PID controller for a given bandwidth.
Análise da morbidade materna grave em uma maternidade pública de Manaus no período de janeiro de 2018 a junho de 2019
Authors: Atayde Kamila da Silva , Said Raíssa Costa , Filho Marcello Facundo do Valle , Viana José Fernandes de Souza
Published: March 2021

Objetivo: Discorrer sobre morbidade materna ou near miss em uma maternidade pública de Manaus. Métodos: Estudo retrospectivo desenvolvido em uma Maternidade pública de Manaus, obtidos por meio de prontuários médicos arquivados no serviço de arquivos médicos da maternidade. Resultados: Os resultados encontrados foram levantados por meio dos critérios e diagnósticos de near miss das pacientes admitidas na unidade de terapia intensiva da Maternidade que estavam no ciclo gravidicio-puerperal (grávidas, em trabalho de parto, que deram à luz ou abortaram dentro de um período de 42 dias) através de variáveis levantadas, cujas pacientes eram mulheres que apresentaram pelo menos um dos critérios de near miss segundo OMS. Conclusão: Evidenciou, entre as pacientes, uma frequência elevada de mulheres jovens, a grande maioria primigesta e que não tiveram assistência pré-natal adequada como preconizada pelo Ministério da Saúde, notou-se também os distúrbios hipertensivos relacionados a gestação e suas complicações como os principais critérios de near miss diagnosticados acometendo essas pacientes, ressaltando assim a importância de obter melhorias em relação a atenção primária em saúde.
Male reproductive health at risk due to exposure to perfluoroalkyl substances: Recent research highlights
Authors: Singh Shilpi , Singh Shio Kumar
Published: March 2021

Perfluoroalkyl substances (PFASs) are a group of synthetic organic chemicals that are persistent in the environment as well as in wildlife and human body. Further, PFASs are considered as persistent organic pollutants. PFASs have been extensively used in many industrial and consumer products over the past several decades and, therefore, they are found in various environmental matrices. A large number of studies during the past decades have reported the toxic effects of these compounds on the male reproductive health including damage to the seminiferous tubules, changes in reproductive hormones level, and low sperm counts and the molecular mechanism(s) involved in such effects. In the present review, we have summarized the reproductive toxicity of some PFASs, namely, perfluorooctanoic acid, perfluorooctane sulfonate, perfluorododecanoic acid, and perfluorononanoic acid in the male. This article briefly describes the findings on PFASs which may attract the attention of the reproductive toxicologists to examine the potential risk to the male reproductive health because of the continued contamination of the environment by these compounds.
Individual & Collective Human Intelligence in Drug Design: Evaluating the Search Strategy
Authors: Cincilla Giovanni , Masoni Simone , Blobel Jascha
Published: March 2021

In recent years, individual and collective human intelligence, defined as the knowledge, skills, reasoning and intuition of individuals and groups, have been used in combination with computer algorithms to solve complex scientific problems. Such approach was successfully used in different research fields such as: structural biology, comparative genomics, macromolecular crystallography and RNA design. Herein we describe an attempt to use a similar approach in small-molecule drug discovery, specifically to drive search strategies of de novo drug design. This is assessed with a case study that consists of a series of public experiments in which participants had to explore the huge chemical space in silico to find predefined compounds by designing molecules and analyzing the score associate with them. Such a process may be seen as an instantaneous surrogate of the classical design-make-test cycles carried out by medicinal chemists during the drug discovery hit to lead phase but not hindered by long synthesis and testing times. The objectives of this case study are to give the first insights towards: the assessment of human intelligence in chemical space exploration problems; compare the performance of individual and collective human intelligence in such a problems; and also contrast some human and artificial intelligence achievements in de novo drug design.
Animal Species Identification of Meat Using MALDI-TOF Mass Spectrometry
Authors: Rau Jörg , Hiller Ekkehard , Männig Annegret , Dyk Martin , Wenninger Olivera , Stoll Philipp , Wibbelt Gudrun , Schreiter Pat
Published: March 2021

We describe the animal species identification of meat using MALDI-TOF mass spectroscopy including the development and validation of a reliable method, qualified for use in the accredited official food-control laboratory. Previous publications had shown the potential of MALDI-TOF MS for animal species differentiation of several kind of food, including meat. Our aim was to establish a rapid and reliable method by means of a simplified sample preparation without prior tryptic digest, an existing popular MALDI system, an independent extensive reference database, and an adequate validation concept. In contrast to the previous works, we consequently use the MALDI user platform “MALDI-UP” to give other food control laboratories the possibility of exchanging reference and validation spectra.
Three- and Four-Site Models for Heavy Water: SPC/E-HW, TIP3P-HW, and TIP4P/2005-HW
Authors: Linse Johanna-Barbara , Hub Jochen S.
Published: March 2021

Heavy water or deuterium oxide, D2O, is used as solvent in various biophysical and chemical experiments. To model such experiments with molecular dynamics simulations, effective pair potentials for heavy water are required that reproduce the well-known physicochemical differences relative to light water. We present three effective pair potentials for heavy water, denoted SPC/E-HW, TIP3P-HW, and TIP4P/2005-HW. The models were parametrized by modifying widely used three- and four-site models for light water, with aim of maintaining the specific characteristics of the light water models. At room temperature, the SPC/E-HW and TIP3P-HW capture the modulations relative to light water of the mass and electron densities, heat of vaporization, diffusion coefficient, and water structure. TIP4P/2005-HW captures in addition the density of heavy water over a wide temperature range.
The Price is Right: Predicting Reagent Prices
Authors: Ofori-Atta Kwabena , Springer Clayton
Published: March 2021

We present a model for estimating the price of a reagent from its chemical structure. It is intended to be useful when doing reagent selection for library design. The model is a Random Forest regressor which is trained on the MolPort catalog of 302K reagents and the log of their price. For descriptors we use topological fingerprints from RDKit: chiral Morgan fingerprints, its medicinal chemistry descriptors, and counts of undetermined chiral centers. The model has an out-of-bag performance of 34% variance explained in log Price. When predicting on known reagents, the model explains 91% of the variance in log Price. We analyzed the model to understand the errors that the model makes. We show that the compounds with the highest errors have only a subtly different structure from similar molecules, but very different in price.
Kinetics of α -glucosidase inhibitory activity and phytochemical analysis of Piper crocatum Ruiz & Pav. leaves ethanol extract
Authors: Muhammad Alfarabi  , Maria Bintang  , Suryani  , Mega Safithri  , Waras Nurcholis
Published: March 2021

α-Glucosidase is an enzymes group that playing essential roles in the digestion of polysaccharide. Inhibitor of a-glucosidase can decrease polysaccharide digestion rate and therefore plays a significant function in preventing the development of diabetes (type 2). Piper crocatum Ruiz & Pav. is an essential herb applied traditionally in Indonesia to treat diabetes mellitus. This work evaluated the a-glucosidase inhibitory activity of P. crocatum leaves ethanol extract. Phytochemical component of the extract was also analyzed. The α-glucosidase inhibitory activity of the P. crocatum leaves ethanol extract was examined by reacting its different concentrations with α-glucosidase and p-nitrophenyl glucopyranoside. Kinetics of the α-glucosidase inhibition was determined using a Lineweaver-Burke plot. Phytochemical in the extract was determined using GC-MS. Ethanol extract of P. crocatum leaves exhibited moderate α-glucosidase inhibitory activity compared with acarbose. Phytochemical analyses showed the presence of stilbene, linolenic acid, phenol, phytosteroid, and α-tocopherol. The competitive action of P. crocatum  leaves ethanol extract is due to its inhibitory effects on α-glucosidase. The stilbene and phenol compounds indicated responsible for anti-diabetic activity from P. crocatum leaves ethanol extract.
Synthesis and Characterization of Some Heterocyclic Compounds and Evaluation of Antibacterial Activity
Authors: Farah Smaysem  , Ahmed Salim
Published: March 2021

In this study, heterocyclic compounds with two nitrogen atoms are prepared by reaction of 2-aminobenzimidazole with formic acid to get amide derivatives (A), reacts with phenylhydrazine to get phenyl hydrazone derivatives (B), reacts with ethyl chloroacetate to obtain ethyl acetate derivatives (C). The derivative (D) obtains on heating in a basic medium. The (B) reacts with 2-chloroacetyl chloride to give derivatives (E). A number of Schiff bases are prepared (F, I) from reacting 2-aminobenzimidazole with benzaldehyde derivatives. The(F) reacts with propargyl bromide to give propargyl bromide derivatives (G). The cyclization with 4-nitrophenyl azide leads to obtain triazole compound (H). The compound (I) reacts with ethyl chloroacetate to give ethyl acetate derivatives (J), reacts with hydrazine to give N-amide hydrazine derivatives (K). The cyclization give rises to 1,3,4-oxadiazole derivatives (L). The compound (I) reacts with sodium azide to obtain tetrazole derivatives (M). Synthesizing of Triazine, Oxadiazole, Triazole, Tetrazole via cyclization of the Schiff base derivatives with ethyl chloroacetate and chloro acetyl chloride, benzoic acid, 4-nitrophenyl azide, sodium azide and phenyl azide are possible respectively. The FT-IR, 13C-NMR and 1H-NMR spectral data give good evidence for the formation of the compounds. Some prepared compounds exhibit antibacterial properties.
Training of women self-help groups against reproductive tract infections - A pilot study
Authors: Ann Merrin George  , Leena K C
Published: March 2021

Reproductive tract infections (RTIs) are silent epidemics and put a heavy toll on women in developing countries. Women, because of their ignorance and socio-cultural inhibitions, hardly seek treatment for RTIs. Women self-help groups (SHGs) if adequately trained, can play an active role in creating awareness and promote healthy behaviours among women. The present study aimed to evaluate the Effectiveness of STAR (Self-help group Training to Alleviate Reproductive tract infection) program on knowledge, practices, skills and health-seeking behaviours on RTIs among self-help group women in the reproductive age group. A quasi-experimental (non-equivalent control group) study with repeated follow-up was done among 63 women belonging to the selected SHG units. Women in the intervention group (n=33) underwent a training program on RTIs and had regular monthly follow-up for 6months, and the comparison group (n=30) only had a routine follow-up. Post-test observations were conducted at the end of three months and six months. The data were analyzed using repeated-measures ANOVA using SPSS package version 16. There was a significant difference in the knowledge, practice, skill and health-seeking behaviour scores at different points of time (P<0.001). However, the between-group pairwise comparison revealed that the training program was effective in improving the mean knowledge (P=0.001), skill (P=0.014) and health-seeking behaviour (P=0.034) scores and had no effect on the practice score (P=0.74). The STAR program was found to be effective in improving the knowledge, skill and health-seeking behaviours of the self-help group women.
KOMPETENSI MANAJERIAL KEPALA TENAGA ADMINISTRASI SMA/MA/SMK DI KABUPATEN BELITUNG
Authors: Zulkifli Tartini,
Published: March 2021

abstractBased on Government Regulation (PP) of the Republic of Indonesia Number 19 Year 2015 on Education Standard, one of components that should belong to school is education staff.  There are several types of education staff, and one of them is administration staff. This research is aimed to describe managerial competency of administration staffs in Belitung Regency and also to overcome the challenge in the implementation of its function. The subject consists of 15 administration heads and 59 administration staffs in various schools. Data collection is conducted by survey and interview. The survey data is analyzed with descriptive statistic using average score, and the interview data is analyzed descriptively. In Belitung Regency, head of administration’s managerial competency is excellent in general. However, there are several sub-competencies which need to be improved including organizational staff competency, decision making, resources optimization, staff supervision and conflict management. The competency managerial optimization could not be separated from the role of The Office of Education and Culture. Keywords:   competency, managerial, administration, head of administration, education staff standard  abstrak Berdasarkan PP RI Nomor 19 Tahun 2005 Tentang Standar Pendidikan, salah satu komponen sekolah yang harus memenuhi kriteria minimal adalah tenaga kependidikan. Tenaga kependidikan yang dimaksud dalam PP RI tersebut salah satunya adalah tenaga administrasi. Dengan demikian, tenaga administrasi sekolah bisa menunjang proses pendidikan untuk mencapai kualitas yang diharapkan bangsa. Penelitian ini bertujuan untuk mendeskripsikan kompetensi manajerial kepala tenaga administrasi sekolah di Kabupaten Belitung serta mengetahui kendala yang dihadapi dalam melaksanakan fungsi manajerial. Subjek penelitian ini adalah 15 kepala tenaga administrasi sekolah dan 59 staf tenaga administrasi sekolah. Pengumpulan data dilakukan dengan teknik angket dan wawancara. Data angket dianalisis dengan teknik statistik deskriptif menggunakan rerata skor, sedangkan data wawancara dianalisis denga teknik deskriptif. Di Kabupaten Belitung, kompetensi manajerial kepala tenaga admnistrasi sekolah secara keseluruhan termasuk kriteria sangat baik. Meski demikian ada beberapa sub kompetensi yang masih perlu ditingkatkan lagi yaitu kompetensi mengorganisasikan staf, mengambil keputusan, mengoptimalkan pemanfaatan sumber daya, membina staf, dan mengelola konflik. Upaya peningkatan kompetensi manajerial kepala tenaga admnistrasi sekolah tidak terlepas dari peran Dinas Pendidikan dan Kebudayaan. Kata Kunci:         kompetensi, manajerial, administrasi, kepala tenaga administrasi, standar tenaga administrasi