bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan Media Pembelajaran Berbasis Video Tutorial Pada Mata Kuliah Pemrograman Visual dengan Metode ADDIE
Authors: Juanda Yeni Marita , Hendriyani Yeka
Published: March 2022

Median Peblajaran ialah penunjang kebutuhan untuk pelaksanaan aktivitas belajar. Melalui pemanfaatan media pembelajaran, baik pendidik maupun peserta didik dapat dimudahkan dengan bantuan media pembelajaran. Pengembangan media pembelajaran bertujuan untuk meningkatkan kualitas dan kuantitas pemahaman dan pendalaman terhadap suatu materi ajar bagi setiap peserta didik. Media pembelajaran pada mata kuliah Pemrograman Visual Program Studi Pendidikan Teknik Informatika Jurusan Teknik Elektronika FT UNP biasanya menggunakan jobsheet. Sejak pandemi Corona Virus Disease 2019 (Covid-19) proses perkuliahan pada mata kuliah tersebut baik dosen maupun mahasiswa terdapat beberapa kendala. Salah satu kendala yaitu interaksi secara langsung di Laboratorium FT UNP tidak dapat dilakukan saat melaksanakan praktikum ini. Berdasarkan kendala yang terjadi, diperlukan suatu pengembangan terhadap media pembelajaran. Solusi yang diberikan terhadap permasalahan tersebut adalah mengembangkan sebuah media pembelajaran berbasis video tutorial. Pengembangan media pembelajaran berbasis vidio tutorial bertujuan mendukung proses pebelajaran pada mata kuliah Pemrograman Visual untuk mahasiswa Program Studi Pendidikan Teknik Informatika. Metode yang digunakan pada pengembangan media pembelajaran ini yaitu ADDIE. Media pembelajaran berbasis vidio tutorial yang dikembangkan dengan memanfaatkan Camtasia Studio 8.0 dan Android Studio sebagai tools utama. Media pembelajaran ini menyediakan beberapa menu utama diantaranya yaitu RPS, material, video, quiz, skor, dan about. Melalui aplikasi media pembelajaran ini baik mahasiswa maupun dosen akan terbantu dalam menyelenggarakan proses belajar mengajar baik secara online maupun offline.
DEVELOPMENT OF NEWTON LAW INTERACTIVE E-LKPD BASED ON MOBILE LEARNING USING LIVE WORKSHEETS IN HIGH SCHOOL
Authors: Wati Diana Anjar , Hakim Lukman , Lia Linda
Published: March 2022

Online learning during the COVID-19 pandemic requires students to study from home, so it is necessary to present teaching materials in the form of interactive worksheets so that scientific activities continue to run well. Therefore, this study aims to develop an interactive e-LKPD on Newton's Law based on mobile learning using live worksheets in high school that are valid, practical, and has a potential impact on learning outcomes in the cognitive domain and learning motivation of students. The development research method uses the Rowntree research model. Rowntree's research model has three stages, namely: planning, development, and evaluation. The evaluation stage uses Tessmer's formative evaluation. The subjects of the study were students of class X at Bina Jaya High School. Based on the results of data analysis, it can be concluded that the interactive e-LKPD Newton's Law based on mobile learning using live worksheets in high school is declared valid, practical and has a potential impact on learning outcomes in the cognitive domain (n-gain of 0.58 in the medium category) and learning motivation (an average of 49.8 in the medium category), so it is suitable for use in the learning process
PEMERIKSAAN ULANG ATAS PEMBATALAN KETETAPAN PAJAK SECARA FORMAL
Authors: Wijaya Suparna , Yudhan Wahyu Illahi
Published: March 2022

Directorate General of Taxes has several times faced the fact that the tax assessments that have been issued have been formally canceled. The purpose of this study is to determine the re-audit procedure for tax assessments that are formally canceled, and the obstacles and solutions in overcoming tax audit problems against audit results disputes. The research method used is descriptive qualitative. The results of the study reveal that a tax assessment that is formally canceled can be followed up by a tax auditor, namely in the form of a new audit or a follow-up tax audit. The new tax audit means that the tax audit is carried out with the usual audit mechanism with a different purpose/regardless of the previous tax audit. A new audit is carried out if the cancellation of the tax assessment occurs because it is not true. Advanced audit means to continue the previous process. The obstacles are external and internal factors. External factors include the provision of tax legal remedies, lack of experience, and lack of legal assistance in dealing with disputes over audit results. Internal factors in the form of disciplinary punishment to tax employees who fail to carry out their duties. The solution can be done in terms of regulation and the effectiveness of tax audits.
Cooperativas de Trabajo y la Dificultad de Alcanzar la Autogestión Horizontal
Authors: Henry Maria Laura , Neffa Julio Cesar
Published: March 2022

Este artículo se propone examinar el surgimiento de una fábrica recuperada por sus trabajadores, cómo se convirtió en una cooperativa de trabajo y su modo de funcionamiento actual, con el objetivo de identificar los alcances y límites de la autogestión.

El caso en estudio es una cooperativa productora de papel, ubicada en la ciudad de La Plata en Argentina. En medio de la crisis económica de 2001, la empresa quebró y los trabajadores la ocuparon para no perder sus puestos de trabajo y continuar con la producción. De esta manera, se convirtió en una empresa bajo la propiedad de sus trabajadores que comenzó a funcionar como una cooperativa.

Los resultados presentados se basan en datos recopilados con diferentes técnicas: entrevistas en profundidad, observación participante, revisión documental (reportajes, artículos de prensa, videos, etc.) y una encuesta aplicada a toda la población de trabajadores de la cooperativa. Los datos recolectados nos permitieron conocer la historia de la cooperativa, analizar los cambios en el proceso laboral y, especialmente, identificar la división social y técnica del trabajo, así como las relaciones laborales existentes.

En la parte central de nuestro artículo desarrollamos una serie de aspectos que consideramos que han sido un obstáculo para que en la cooperativa pudiese desplegarse todo el potencial de la autogestión. Al respecto, examinamos primero en qué sentido la autogestión emergió como una estrategia de tipo defensiva para conservar los puestos de trabajo y no fue un fin en sí mismo. En segundo término, mostramos por qué en la cooperativa bajo análisis hubo una difusión limitada de los principios de la autogestión y del cooperativismo. Esto impidió que surgiese una nueva cultura laboral, relaciones de trabajo basadas en la colaboración y la confianza, y una nueva visión sobre el proceso productivo en la cual todos los trabajadores se sintieran comprometidos en participar activamente en la toma de decisiones. En tercer lugar, describimos la existencia de una fragmentación al interior del colectivo de trabajadores, basada en la distancia generacional y en valores sobre el trabajo diferenciales, lo cual ha obstaculizado la consolidación de un colectivo de trabajadores comprometido con objetivos (productivos y sociales) compartidos. Por último, explicamos en qué sentido los determinantes técnicos y tecnológicos, así como el entorno económico más amplio han limitado la expansión de la autogestión en la fábrica bajo estudio.
Evaluación de la Eficiencia de Gestión de las Sociedades de Inversión Básicas Especializadas en Fondos para el Retiro
Authors: Atlatenco Ibarra Quetzalli
Published: March 2022

El financiamiento de las pensiones contributivas por jubilación emanadas de los principales sistemas de seguridad social en México corresponde al modelo de contribución definida y capitalización individual. Por esa razón tiene particular relevancia la eficiencia de las estrategias de inversión que pongan en práctica las entidades financieras creadas expresamente para administrar los recursos que cada trabajador tiene en su cuenta individual destinada a afrontar sus gastos en la vejez. En esta investigación se realiza una evaluación de la eficiencia de gestión de las sociedades de inversión especializadas en el ahorro para el retiro con base en su rendimiento y gestión desde diciembre de 2012 a noviembre de 2019. Para ello se calculan algunos índices correspondientes a la teoría moderna de cartera propuesta por Henry Markowitz. Se comprobó que, a mayor rendimiento, mayor exposición al riesgo.
The analysis of birch pollen season in selected cities of Poland in 2021
Authors: Rapiejko Joanna , Puc Małgorzata , Malkiewicz Małgorzata , Piotrowska-Weryszko Krystyna , Ziemianin Monika , Siergiejko Grzegorz , Dąbrowska-Zapart Katarzyna , Jurkiewicz Dariusz , Lipiec Agnieszka
Published: March 2022

The study aims to monitor the birch pollen season in selected Polish cities: Bialystok, Bydgoszcz, Cracow, Lublin, Olsztyn, Opole, Sosnowiec, Szczecin, Warsaw, Wroclaw and Zielona Gora in 2021. Pollen concentrations were recorded using a Burkard type sampler operating in a continuous volumetric mode. The birch pollen season of 2021 started during the first and second decade of April. In south-western Poland it began about 10 days earlier (April 7th or 10th) than in north-eastern regions (April 18th or 19th). The average length of the season was 31 days. The highest daily concentrations and annual pollen grains sum (seasonal pollen integral) were the most variable season characteristics. The maximum concentrations of birch pollen were recorded between April 21st (in Wroclaw) and May 1st (in Sosnowiec and Warsaw). It ranged from 222 p/m3 in Cracow up to 1997 p/m3 in Wroclaw. SPI was the lowest in Cracow (1573) and Sosnowiec (1763) and the highest in Bydgoszcz (5474) and Wroclaw (5072). The longest exposure to high concentrations of birch pollen, lasting 16–18 days, was detected in Szczecin, Olsztyn and Bydgoszcz. The abundance of birch pollen in Poland in 2021 was not as high as in 2019 and 2020, which, combined with the protective effect of mouth and nose masks due to COVID-19 pandemic, may have resulted in less severe allergy symptoms in sensitized individuals than in previous years.
Evaluation of the accuracy of three-dimensionally printed patient-specific guides for transsphenoidal hypophysectomy in small-breed dogs
Authors: Roh Yoonho , Kim Daehyun , Jeong Seongmok , Lee Haebeom
Published: March 2022

OBJECTIVE

To assess the accuracy of transsphenoidal hypophysectomy using 3-D printed patient-specific guides (3D-PSGs) in small-breed dogs.

ANIMALS

Heads obtained from the cadavers of 19 small-breed dogs (ex vivo portion of study) and 3 healthy adult (3 to 4 years) purpose-bred Beagles with a median body weight of 9.2 kg.

PROCEDURES

In the ex vivo study, CT images of the cadavers were collected. The position, width, and length of the pituitary fossa and the pilot hole (insertion angle and place) were measured. Using PSGs, 19 pilot holes were made for the pituitary gland fossa, and CT was performed to assess the position accuracy. In the in vivo study, 3 surgical windows from the pilot holes were made using PSGs. Repeated CT and MRI were performed to evaluate the safeness and effectiveness of PSGs, followed by necropsy.

RESULTS

In the ex vivo study, the median (interquartile range) difference between the pre- and postoperative insertion angles was 2° (0° to 3.5°) and the median deviation of the pilot hole was 0.46 mm (0 to 1.58 mm). In the in vivo study, the surrounding structures were not damaged, and favorable outcomes were evident in terms of the shape, size, and position of the surgical window.

CLINICAL RELEVANCE

3D-PSGs provided a safe and effective surgical window for transsphenoidal hypophysectomy. Our findings emphasized the applicability of PSGs in brain surgery, in terms of accuracy and effectiveness.
Hubungan Antara Self Control Dengan Nomophobia pada Mahasiswi Fakultas Psikologi Universitas Kristen Satya Wacana
Authors: Sapulete Citra Wira , Ambarwati Krismi Diah
Published: March 2022

Penelitian ini merupakan penelitian kuantitatif dengan jenis penelitian korelasional. Tujuan dari penelitian adalah untuk melihat hubungan antara self control dengan nomophobia pada mahasisiwi Fakultas Psikologi Universitas Kristen Satya Wacana. Adapun hipotesis penelitian yang diajukan dalam penelitian ini, yakni ada hubungan yang negatif dan signifikan antara self control dengan nomophobia pada mahasiswi Universitas Kristen Satya Wacana. Total partisipan dalam penelitian ini sebanyak 213 mahasisiwi dengan menggunakan teknik sampling purposive. Pengumpulan data dilakukan dengan cara penyebaran kuesioner secara online melalui google form. Terdapat dua alat ukur yang digunakan dalam penelitian ini, yaitu Self Control Scale (SCS) yang dibuat oleh  Tangney,  Baumeister Boone (2004) dengan skor reliabilitas sebesar 0,839. Selain itu ada Nomophobia Questionnaire (NMP-Q) yang dibuat oleh Yildirim (2014) dengan skor reliabilitas sebesar 0,924. Hasil yang diperoleh dari penelitian ini adalah terdapat hubungan negatif dan signifikan antara self control dan nomophobia (rxy= -0,372; 0,00 p0,05). Dengan demikian, bahwa hipotesis dalam penelitian ini diterima..
Psychology of Breastfeeding: From Self Narration to Digital Technology
Authors: Murty Ade Iva , Anjani Safira Binar
Published: March 2022

Background: Breastfeeding has been a very precious source for the development of infants and children. Generally, most of the studies about breastfeeding come from a medical knowledge point of view. However, the process of sustaining exclusive breastfeeding is not an easy task for a mother. As breastfeeding involves a mother's decision-making process, the study explores how mothers live in a megapolitan area, preserving exclusive breastfeeding until baby 6 months old and partially continued up to 2 years old. Psychology emphasizes individual (psychological) and macro factors which have a significant role in enabling exclusive breastfeeding.   Methodology: The study methodology was qualitative with case study type. Methods of data collection were an in-depth interview and on-the-spot interview observation. We have interviewed 4  participants. All of them are urban mothers (women live in megapolitan areas of Jakarta Greater Area or JABODETABEK). Age ranges from 20 to 40 years old, with at least an experience of exclusive breastfeeding and the child’s age currently not more than 12 years old. 2 out of 4 participants are working mothers, who have to strive every day between domestic and work domain.Result: All 4 research subjects are typically kind of “pejuang ASI” (breastfeeding warrior), a term used for representing a maternal woman who fights hard to breastfeed, as the best nutrition for a baby. It was shown that psychological processes of preserving exclusive breastfeeding of an urban mother significantly reflect the role of self-narration around the perception of breastfeeding as part of “natural mother” schema and how digital technology helps a mother to get more support and solve breastfeeding and baby’s problems.Conclusion:  First Mother’s schema about breastfeeding and attachment to the baby are important to motivate her to maintain exclusive breastfeeding. we need to know how her schema about breastfeeding and her attachment to the baby.  Second, it is important to identify her skills and knowledge on using digital technology diligently, for a more productive and comfortable process of delivering the best nutrition for the baby.
Identification of Environmental Change in Bukit Kerang, Aceh Tamiang Regency Using Landsat Satellite Imagery
Authors: Simatupang Sphinoza Lisnaria , Rahmatsyah Rahmatsyah
Published: March 2022

Changes in land cover and temperature in Bukit Kerang have been investigated using Landsat satellite images. We used Landsat 5 TM Landsat satellite imagery in 1988, Landsat 7 ETM in 2000, and Landsat 8 OLI in 2020. The ENVI 4.7 and ArcGIS 10.3 software was used to perform radiometric corrections, image cropping, image classification, image reclassification, calculating area, and layouts. Changes in land cover and land area in 1988, 2000, and 2020 affected the surface temperature conditions in those three years. In 1988, the dominant land area of forest cover was 5,926.44 ha (1 ha = 104 m2), with the dominant temperature distribution of 17.2Â° C. In 2000, there was an increase in settlements by 25.56 ha and rice field area, which caused an increase in the temperature distribution of 19.7 â€“ 25.4Â° C. In 2020, forest type land cover changes into plantations, fields, and settlements decreased by 3,731.91 ha, increasing temperature distribution of 20.6 â€“ 21.8Â° C. Thus, there is a strong relationship between changes in land cover and change in surface temperature in Bukit Kerang area.
DESIGN AND DEVELOPMENT OF A MOVIE RECOMMENDATION SERVICE
Authors:   Omsk State Technical University, Omsk, Russia, Salenko A. A. , Morar E.V. ,   Omsk State Technical University, Omsk, Russia
Published: March 2022

The article discusses two components of the service: the server part of the application for user interaction and the recommendation algorithm embedded in this service. In the process of work, training data was collected and processed, a neural network was designed and trained, recommendations were generated based on various filtering algorithms. The result of the work is a service for the selection of films
PRACTICAL APPLICATION OF THE ALGORITHM FOR SOLVING THE COMMISSIONER PROBLEM
Authors:   Omsk State Technical University, Omsk, Russia, Kurinnaya A. A. , Fedorov I. V. ,   Omsk State Technical University, Omsk, Russia
Published: March 2022

The possibility of reducing the logistics costs of transportation by solving the traveling salesman problem is considered. An algorithm for solving the problem using the computing power of the "Solver" add-in of OpenOffice Calc is proposed. On the basis of the proposed algorithm, a practical situation is resolved and an optimal route for OpticsOmsk is drawn up
ANALYTICAL REVIEW OF THE ACHIEVED RESULTS IN THE FIELD OF PERSONAL IDENTIFICATION WITH PROTECTION OF BIOMETRIC STANDARDS FROM COMPROMATION
Authors:   Omsk State Technical University, Omsk, Russia, Inivatov D. P. , Sulavko A. E. ,   Omsk State Technical University, Omsk, Russia
Published: March 2022

The article provides an overview of the results achieved in the field of subject recognition based on the provided biometric images: faces, fingerprints, as well as voice images. At the same time, various methods and algorithms are considered, in which the speaker recording files have passed different stages of preprocessing. In addition to the speaker's identification, the methods of protection against presentation attacks are also analyzed, the results of measures to conduct the effectiveness of various classifiers are analyzed.
Autoeficácia materna em primigestas e a manutenção do aleitamento materno
Authors: Martins Nathália , Antikadjian Raissa Hernandes , Pimentel Ágata Bruna Neto Maia , Silva Felipe Bueno da , Brito Gabriella Vasconcelos de , Frugis Letícia Amaral , Botéchia Júlia Zanco , Lodi Jucilene Casati , Rodrigues Aline Scharr , Milagres Clarice Santana
Published: March 2022

Objetivo: Verificar a associação da autoeficácia da mulher primigesta com a manutenção do Aleitamento Materno (AM) até o sexto mês de vida da criança. Métodos: Trata-se de uma revisão de literatura integrativa, incluindo publicações entre 2011 e 2021, categorizando os achados através de uma análise robusta, com interpretação dos dados e síntese do conhecimento. Foi utilizada a questão norteadora “mulheres primigestas têm menos confiança em manter o aleitamento materno?”. Resultados: Foram encontrados 26 artigos incialmente, permanecendo quatro artigos após eliminação de duplicatas e aplicando os critérios de inclusão e exclusão classificados previamente, excluindo assim os demais artigos que não se enquadravam. Considerações finais: Estudos sobre autoeficácia materna em primigestas e manutenção do AM nestas mulheres são reduzidos na literatura até o momento. Diversos fatores influenciam a adesão desta mulher frente ao AM. O desafio de amamentar, associado à pior condição socioeconômica e baixa escolaridade das mulheres primigestas contribui para o desmame precoce.
Impact of Vibrational Frequencies on State Mood and Mindfulness
Authors: Van Steenhuyse Erica , Rhoads Michael
Published: March 2022

Vibration is a part of everyday life, whether we are aware of it or not. Everyone experiences vibration in a variety of different ways: intentionally with music and speech, environmentally by cars, computers, phones, etc., and unconsciously, because there are many vibrational frequencies that are not audible to the human ear. Previous studies have focused on whether vibrational exposure impacts mood or impacts mindfulness, but the aim of the current study was to examine whether exposure to vibration of high and low frequencies has any impact on state mood and mindfulness levels together. Participants (n = 28) were assigned to listen to either high frequencies (20,000Hz and above) or low frequencies (50Hz or below). Regardless of intervention, participants completed the State Mindfulness Survey (SMS) and the Positive and Negative Affect Schedule (PANAS) questionnaires before and after their retrospective intervention. A repeated measures MANOVA was conducted to examine group differences on mood and affect. There was no significant time by condition interactions for any of the dependent variables. There were various limitations in this study that may have led to no significant results, such as insufficient sample size combined with low amplitude levels and short frequency exposure times during intervention.
Konzepte, Strategien und Systeme des Qualitätsmanagements
Authors: Seghezzi Hans Dieter
Published: March 2022

No Abstract
Eröffnung des Nachdiplomstudiums Umwelt (NDS-U) an der Ingenieurschule beider Basel (IBB) in Muttenz
Authors: Heim Thomas
Published: March 2022

No abstract.
Side chain interactions govern the response of polypeptide alpha-helices under mechanical stress and prevent the formation of beta-sheets
Authors: Asano Marie , Sluysmans Damien , Willet Nicolas , Bonduelle Colin , Lecommandoux Sébastien , Duwez Anne-Sophie
Published: March 2022

Secondary a-helix and b-sheet structures are key scaffolds around which the rest of the residues condense during protein folding. They are crucial for proteins to adopt their correct native structure. Despite their key role in numerous processes to maintain life, little is known about their properties under force. Their stability under mechanical stress, as constantly experienced in the turbulent environment of cells, is however essential. Here, we designed and synthesized two pH-responsive polypeptides, poly(L-glutamic acid) and poly(L-lysine), for optimal interfacing with an AFM single-molecule force spectroscopy set-up to probe the mechanical unfolding of a-helix and b-sheet secondary motifs. The force experiments, supported by simulations, reveal a superior mechanical stability of the poly(L-Lysine) a-helix, which we attribute to hydrophobic interactions of the alkyl side chains. Most importantly, our results show that these interactions play a key role in inhibiting the formation of a metastable b-sheet-like structure when the polypeptide is subjected to mechanical deformations, which might have important implications in the mechanism behind polyQ diseases.
Density Functional Theory of Water with the Machine-Learned DM21 Functional
Authors: Palos Etienne , Lambros Eleftherios , Dasgupta Saswata , Paesani Francesco
Published: March 2022

The delicate interplay between functional-driven and density-driven errors in density functional theory (DFT) has hindered traditional density functional approximations (DFAs) from providing an accurate description of water for over 30 years. Recently, the deep-learned DeepMind 21 (DM21) functional has been shown to overcome the limitations of traditional DFAs as it is free of delocalization error. To determine if DM21 can enable a molecular-level description of the physical properties of aqueous systems within Kohn-Sham DFT, we assess the accuracy of the DM21 functional for neutral, protonated, and deprotonated water clusters. We find that the ability of DM21 to accurately predict the energetics of aqueous clusters varies significantly with cluster size. Additionally, we introduce the many-body MB-DM21 potential derived from DM21 data within the many-body expansion of the energy and use it in simulations of liquid water as a function of temperature at ambient pressure. We find that size-dependent functional-driven errors identified in the analysis of the energetics of small clusters calculated with the DM21 functional result in the MB-DM21 potential systematically overestimating the hydrogen-bond strength and, consequently, predicting a more ice-like local structure of water at room temperature.
Accelerated Synthesis and Discovery of Covalent Organic Framework Photocatalysts for Hydrogen Peroxide Production
Authors: Zhao Wei , Yan Peiyao , Li Boyu , Bahri Mounib , Liu Lunjie , Zhou Xiang , Clowes Rob , Browning Nigel D. , Wu Yue , Ward John W. , Cooper Andrew I.
Published: March 2022

A high-throughput sonochemical synthesis and testing strategy was developed to discover covalent organic frameworks (COFs) for photocatalysis. In total, 76 conjugated polymers were synthesized, including 60 crystalline COFs of which 18 were previously unreported. These COFs were then screened for photocatalytic hydrogen peroxide (H2O2) production using water and oxygen. One of these COFs, sonoCOF-F2, was found to be an excellent photocatalyst for photocatalytic H2O2 production even in the absence of sacrificial donors. However, after long-term photocatalytic tests (96 h), the imine sonoCOF-F2 transformed into an amide-linked COF with reduced crystallinity and loss of electronic conjugation, decreasing the photocatalytic activity. When benzyl alcohol was introduced to form a two-phase catalytic system, the photo-stability of sonoCOF-F2 was greatly enhanced, leading to stable H2O2 production for at least one week.
Attomolar sensitivity microRNA detection using real-time digital microarrays
Authors: Ekiz Kanik Fulya , Celebi Iris , Sevenler Derin , Tanriverdi Kahraman , Lortlar Unlu Nese , Freedman Jane , Unlu Selim
Published: March 2022

MicroRNAs (miRNAs) are a family of noncoding, functional RNAs. With recent developments in molecular biology, miRNA detection has attracted significant interest, as hundreds of miRNAs and their expression levels have shown to be linked to various diseases such as infections, cardiovascular disorders and cancers. DNA microarray technology is a powerful and high throughput tool for nucleic acid detection and quantification, however, traditional methods do not meet the demands in sensitivity and specificity presenting significant challenges for the adaptation of miRNA detection for diagnostic applica-tions. In this study, we developed a highly sensitive and multiplexed digital microarray using plasmonic gold nanorods as labels. For proof of concept studies, we conducted experiments with two miRNAs, miRNA-451a (miR-451) and miRNA-223-3p (miR-223). We demonstrated improvements in sensitivity and specificity by implementing real-time tracking of the target molecules binding to multiplexed probes on the sensor surface, in comparison to conventional end-point assays that employ capture on solid phase support. Real-time particle tracking overcomes the sensitivity limitations for detection of low-abundance biomarkers in the presence of low-affinity but high-abundance background molecules, where endpoint assays fall short. The limit of detection (LOD) calculations with end-point assay format yielded 2.22 fM for miR-223 and 228 aM for miR-451 after a total of 10hr incubation time. The implementation of dynamic tracking improved the LODs in real-time experiments to 13 aM (less than 1600 copies in 0.2ml of sample) for miR-223 and 6.2 aM (less than 800 copies in 0.2ml of sample) for miR-451 after a total incubation time of 35 minutes.
The dielectric function profile across the water interface through surface-specific vibrational spectroscopy and simulations
Authors: Chiang Kuo-Yang , Seki Takakazu , Yu Chun-Chieh , Ohto Tatsuhiko , Hunger Johannes , Bonn Mischa , Nagata Yuki
Published: March 2022

The dielectric properties of interfacial water on sub-nanometer length scales govern chemical reactions, carrier transfer, and ion transport at interfaces. Yet, the nature of the interfacial dielectric function has remained debated as it is challenging to access the interfacial dielectric with sub-nanometer resolution. Here, we use the vibrational response of interfacial water molecules probed using surface-specific sum-frequency generation (SFG) spectra to obtain exquisite depth resolution. Different responses originate from water molecules at different depths, and report back on the local interfacial dielectric environment via their spectral amplitudes. From experimental and simulated SFG spectra at the air/water interface, we find that the interfacial dielectric constant changes drastically across a ~1 Å thin interfacial water region. The strong gradient of the interfacial dielectric constant leads, at charged planar interfaces, to the formation of an electric triple layer that goes beyond the standard double-layer model.
The role of asymmetry on the photoisomerization of dithienylethene molecule photoswitch
Authors: Salazar Edison , Reinink Suzanne , Faraji Shirin
Published: March 2022

Dithienylethene (DTE) molecular photoswitches have shown to be excellent candidates in the design of efficient optoelectronic devices, due to their high photoisomerization quantum yield (QY), for which symmetry is suggested to play a crucial role. Here, we present a theoretical study on the photochemistry of a non-symmetric dithienylethene photoswitch, with a special emphasis on the effect of asymmetric substitution on the photocyclization and photoreversion mechanisms. We used the Spin-Flip Time Dependent Density Functional Theory (SF-TDDFT) method to locate and characterize the main structures (conical intersections and minima) of the ground state and the first two excited states, S1 and S2, along the ring opening/closure reaction coordinate of the photocyclization and photoreversion processes, and to identify the important coordinates governing the radiationless decay pathways. Our results suggest that while the main features that characterize the photoisomerization of symmetric DTEs are also present for the photoisomerization of the non-symmetric DTE, the lower energy barrier on S1 along the cycloreversion reaction speaks in favor of a more efficient and therefore a higher cycloreversion QY for the non-symmetric DTEs, making them a better candidate for molecular optoelectronic devices than their symmetric counterparts.
Acerca del concepto de universalidad en el Derecho Penal Internacional
Authors: Mattos Rázuri Sergio
Published: March 2022

A lo largo del presente artículo, el autor buscará probar que el concepto de universalidad —que sirve de base para la criminalización universal de hechos particulares— no es más que una ficción que no responde a las razones más nobles. Construirá su análisis sobre la base de las narrativas de humanidad y su atrocidad, para luego analizar el concepto de universalidad, como un atributo generalmente aceptado en el Derecho Internacional, y examinar la discusión que existe con respecto al Derecho natural y el positivismo. Para terminar, realizará una crítica constructiva sobre el concepto, estableciendo la lógica, fortalezas e inconsistencias detrás de las narrativas de humanidad y atrocidad de la universalidad en el Derecho Penal Internacional.
¿Pueden las perspectivas del Derecho Medioambiental ayudar a mejorar nuestra comprensión sobre los Derechos Humanos en el Derecho Internacional?
Authors: Pinto-Bazurco Barandiarán José Félix , Rodríguez Sánchez Sandra Luisana
Published: March 2022

Si bien algunas legislaciones reconocen el derecho a un medio ambiente sano como un derecho fundamental, este reconocimiento aún no es universal. En el presente artículo, exploramos la relación del derecho a un medio ambiente sano con los Derechos Humanos, además de su lugar y aproximaciones para ser reconocido en el sistema internacional de los Derechos Humanos. Para ello, se incluye un análisis sobre las acciones estratégicas presentadas ante tribunales de justicia como una herramienta para lograr dicho reconocimiento.
Protección de los diseños industriales en los países de la Comunidad Andina y el sistema del Arreglo de La Haya
Authors: Barreto Guinea Ana Teresa , Allemant Castañeda Nicole
Published: March 2022

El presente trabajo pretende desarrollar los temas relacionados con (i) la importancia de la protección de los derechos industriales; (ii) el marco normativo nacional, supranacional e internacional, sobre la protección de la propiedad industrial e intelectual, con un especial enfoque en la Decisión 486 de la Comunidad Andina y el Decreto Legislativo 1075; (iii) el Arreglo de La Haya, el tratado internacional que rige el registro internacional de dibujos y modelos industriales en diversos países, mediante un registro central; y, (iv) el sistema internacional del Arreglo de La Haya, el cual permite conceder protección a los dibujos y modelos industriales en varios países o regiones con un mínimo de formalidades.
Irretroactividad de las normas tributarias y Primera Disposición Complementaria del Decreto Legislativo 1421
Authors: Bardales Castro Percy Enrique
Published: March 2022

El presente documento pretende brindar unas breves reflexiones sobre el efecto jurídico que ha generado la entrada en vigencia de la Primera Disposición Complementaria Transitoria del Decreto Legislativo 1421 para fines del régimen normativo relativo al inicio del plazo de prescripción para el ejercicio de la potestad de la autoridad tributaria para exigir el pago de la deuda tributaria, modificado en su oportunidad por el Decreto Legislativo 1113.
Conserved exchange of paralog proteins during neuronal differentiation
Authors: Di Fraia Domenico , Anitei Mihaela , Mackmull Marie-Therese , Parca Luca , Behrendt Laura , Andres-Pons Amparo , Gilmour Darren , Helmer Citterich Manuela , Kaether Christoph , Beck Martin , Ori‬‬ Alessandro
Published: March 2022

Gene duplication enables the emergence of new functions by lowering the evolutionary pressure that is posed on the ancestral genes. Previous studies have highlighted the role of specific paralog genes during cell differentiation, for example, in chromatin remodeling complexes. It remains unexplored whether similar mechanisms extend to other biological functions and whether the regulation of paralog genes is conserved across species. Here, we analyze the expression of paralogs across human tissues, during development and neuronal differentiation in fish, rodents and humans. Whereas ∼80% of paralog genes are co-regulated, a subset of paralogs shows divergent expression profiles, contributing to variability of protein complexes. We identify 78 substitutions of paralog pairs that occur during neuronal differentiation and are conserved across species. Among these, we highlight a substitution between the paralogs SEC23A and SEC23B members of the COPII complex. Altering the ratio between these two genes via RNAi-mediated knockdown is sufficient to influence neuron differentiation. We propose that remodeling of the vesicular transport system via paralog substitutions is an evolutionary conserved mechanism enabling neuronal differentiation.
ENGINEERING CHEMISTRY LABORATORY
Authors: M Gowdhamamoorthi , S Kalaivani
Published: March 2022

This book on “ENGINEERING CHEMISTRY LABORATORY” covers the complete syllabus prescribed by the Anna University, Chennai for the first semester B.E/B.Tech. Degree course under Choice Based Credit System with the new regulation 2021.This book covers with both Volumetric analysis and Physical Chemistry experiments, has been presented 15 experiment systematically. Before starting the experiments, the students are advised to go through the procedure, given in the book, in order to carry out the experiments with perfect understanding. At the end of the book short procedures, Viva-voice questions and answers for preparation of various reagents are attached.We hope that this book will be useful to both teachers and students. Finally we would request the readers to kindly send their valuable comments and suggestions towards the improvement of the book and the same will be gratefully acknowledged.
Work engagement and organizational commitment on millennial employees in terms of authentic leadership perception
Authors: Hafiz Muhammad , Indrayanti Indrayanti
Published: March 2022

Work engagement and organizational commitment are research concepts that still need to be studied in Indonesia. Millennial employees are the generation that is dominating almost all organizations in Indonesia. The study aimed to examine how the role of authentic leadership is on work engagement and organizational commitment for millennial employees. Data were collected from 171 millennial employees in private and start-up companies through online and offline surveys. The quantitative method by survey method was applied in this study. Three scales were used to collect data, including the Utrecht Work Engagement Scale of work engagement (17 items), Organizational Commitment Questionnaire (15 items), and Authentic Leadership Questionnaire (24 items). The data analysis used multivariate analysis of covariance (MANCOVA). Results showed authentic leadership has a positive role in work engagement and organizational commitment, so the research hypothesis is accepted. This study further clarifies the contribution of authentic leadership in generating high work engagement and organizational commitment of the millennial generation. By applying authentic leadership, the leader may enhance millennial employees' work engagement and organizational commitment.
Resilience process of a victim sexual violence in women: Transformation from victim to activist
Authors: Inayah Risma , Palila Sara
Published: March 2022

Humans face numerous life challenges and phenomena that could cause traumatic feelings, such as violent cases. Amid these challenges, resilience was an essential psychological ability for individuals, including victims of sexual violence. Thus, this study aimed to determine the resilience process, factors that influenced and the meaning of the resilience process traversed by women victims of sexual violence. This research involved three informants who were victims of sexual violence. A qualitative method with a phenomenological approach was applied in this study. The semi-structured interviews were conducted in data collection. The data were analyzed with interpretative phenomenological analysis. Based on the analysis of transcribed interviews, three themes emerged: experienced various unpleasant emotions, coped and adapted with the situation, experienced several changes in herself and became resilient. Participants also have their meaning of the resilience process. Furthermore, the new finding is the pain victims experience, and their coping forces them to become resilient and join the organization that focuses on against sexual violence. Internal and external factors affect the resilience of victims, including empathy, social concern, and goals to be achieved. The implication of this study is to enhance the current literature on resilience and as additional knowledge to understand the resilience process and factors that influence victims of sexual violence to become resilient.
Regulations for production compliance assessment
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Anikienko T.I. , Mikhaylova K.V. , Kuptsova S.V.
Published: March 2022

В учебном пособии представлены новые правила обязательного подтверждения соответствия продукции, которые устанавливают порядок обязательного подтверждения соответствия продукции, включенной в единый перечень продукции, подлежащей обязательной сертификации, и единый перечень продукции, подлежащей декларированию соответствия. Предназначено для студентов, обучающихся по направлению 19.03.03 Продукты питания животного происхождения, 19.04.03 Продукты питания животного происхождения, 35.03.07 Технология производства и переработки сельскохозяйственной продукции, 15.03.02 Технологические машины и оборудование, 19.03.02 Продукты питания из растительного сырья.
ARTIFICIAL INTELLIGENCE IN INTERNATIONAL RELATIONS: ROLE AND RESEARCH DIMENSIONS
Authors:   Saint Petersburg State University, Grishanina Tat’yana A.
Published: March 2022

The article covers certain aspects of artificial intelligence in international relations. The study aims at identifying the role and key dimensions of AI research and application in international relations. The results of the study reveal paradigmatic differences in the approaches to the research of AI in international relations. Research dimensions include international security and the new types of conflicts, technological competition and sustainable development, ethics and human rights. As far as the application of AI in foreign policy is concerned, the expert discourse was analyzed and three utilitarian functions of AI were identified: 1) AI as a diplomatic tool; 2) AI as a topic for negotiations; 3) AI as a factor of the changes in the international environment. Thus, AI is one of the key technologies for the next decade with the potential to become a core factor in the redistribution of power in the international system. As part of international relations digitalization, AI influences the actors’ perceptions of the changing system. At this point, most research papers deal with AI within the framework of cybersecurity. This article aligns various approaches and presents a comprehensive perspective of AI in international relations.
EURASIAN ECONOMIC UNION AND IRAN
Authors:   Russian State University for the Humanities, Ebrahimitorkaman Ali
Published: March 2022

After the collapse of the USSR, Russia lost its superpower status as well as its influence over a very large territory in Eastern Europe, Central Asia and the Caucasus. The Western countries, primarily the United States, took advantage of this to include these regions in the orbit of their influence. At the beginning of the 21st century, Russia has begun to regain its presence in Central Asia and the Caucasus by creating such organizations as the EAEU and the SCO. At the same time, Russia pursued the goal of returning the superpower positions lost after the collapse of the USSR. One of the important reasons for the formation of the EAEU was that some countries of the former USSR felt the need to restore economic ties that had existed before 1991. This organization soon began to expand towards the Middle East. Iran was one of the first countries in the region to start negotiations with the organization. This article presents an analysis of Iran’s relationship with the EAEU. In 2019, the Agreement on the Free Trade Zone of Iran with the EAEU entered into force, which led to a significant increase in bilateral trade. A possible entry into the EAEU for Iran, on the one hand, will not bring very large economic benefits due to the peculiarities of the structure of its economy and the need for modern technologies that this organization cannot provide for this country. However, it will allow Iran to expand and deepen its interaction with the countries of Central Asia and resist the US pressure. In particular, it will be possible for Iran to neutralize the impact of the devastating American economic sanctions by developing ties with the EAEU in the field of economy.
“THE GOOD, THE BAD AND THE EVIL”: THE IMAGES OF AMERICAN “OTHER” IN RUSSIAN ANTI-TERROR CINEMA OF THE 21ST CENTURY
Authors:   independent researcher, Vasilenko Dar’ya V.
Published: March 2022

The article examines the images of the American “Other” and their transformation in accordance with the foreign policy contexts. Due to the intensity of its impact on public perception and high sensitivity to international relations dynamics, the Russian film industry serves as a basis for studying this subject. To portray the connection between the foreign policy crises and the range of the American “Other” representations more vividly, the author focuses on such a peculiar genre of contemporary cinema as the anti-terror cinema discourse. This type of the cinema discourse, as proven by the instances of the American “Other” portrayal, comprises a fictitious narrative as well as political allegories. A more detailed study of their existential contexts provides that the negative representation of Americans is nourished by political conflicts. As they accelerate, they generate the tendency of a ‘new anti-americanism’, an intended distortion of the onscreen image of the American “Other”. The article suggests that the modern ways of portraying Americans are hardly novel, hence the sustainability of the ‘enemy’ image. The connection with foreign policy contexts, however, does not allow us to make a definite conclusion about the future of the American “Other” on the Russian screen. The probability of expanding the representation spectrum towards the positive side is also explained by the active exploitation of the Cold War as a metaphor of the highest point of ‘no return’ in the Russian-American relations.
Pengolahan Minyak Goreng Bekas (Jelantah) menjadi Bahan Bakar Setara Solar (Biodiesel) dengan Proses Transesterifikasi
Authors: Sidjabat Oberlin
Published: March 2022

Minyak goreng bekas atau yang sehari-hari disebut jelantah, merupakan salah satu sumber polusi apabila dibuang sembarangan. Pengertian istilah jelantah adalah sisa-sisa dari minyak goreng setelah digunakan beberapa kali. Pada umumnya minyak goreng bekas mengandung senyawa-senyawa antara lain: polimer, aldehida, asam lemak, senyawa aromatik, dan lakton. Untuk menghindari bahaya yang dapat ditimbulkan maka perlu dicari jalan keluar untuk memanfaatkan minyak goreng bekas tersebut. Salah satu cara adalah dengan mengolahnya melalui proses kimia, dalam hal ini transesterifikasi, yang sangat sederhana (Kac, 2003). Di sisi lain, bahan bakar minyak banyak menghasilkan gas buang yang dapat menyebabkan pencemaran lingkungan sehingga perlu dicari bahan bakar yang akrab lingkungan. Salah satu bahan bakar yang akrab lingkungan adalah biodiesel. Biodiesel adalah suatu nama generik untuk bahan bakar setara bahan bakar minyak solar yang diperoleh dari sumber yang dapat diperbaharui (renewable sources), minyak nabati dan lemak hewan, dengan proses esterifikasi yaitu dengan mereaksikan minyak dan alkohol dengan bantuan suatu katalis. Biodiesel mempunyai kelebihan bila dibandingkan dengan bahan bakar minyak diesel (solar) yang diperoleh dari minyak bumi, antara lain: mempunyai sifat pelumasan yang lebih baik sehingga memperpanjang umur mesin; merupakan bahan bakar yang aman karena mudah ditangani dan tidak beracun; mempunyai gas buang yang relatif bersih
Kompatibilitas Fluida Injeksi dan Formasi Batuan pada Reservoir dengan Injeksi Air
Authors: Sugihardjo Sugihardjo
Published: March 2022

Jutaan barel tambahan produksi minyak dapat diperoleh dari injeksi air, yang merupakan salah satu metode peningkatan perolehan minyak yang murah. Oleh karena itu mengoptimasi injeksi air merupakan tahap yang sangat penting agar diperoleh produksi yang optimal. Pada proses peningkatan perolehan minyak sekunder maupun tersier akan terjadi interaksi antara fluida injeksi dan fluida reservoir maupun batuan reservoir. Oleh karena itu perlu dilakukan kajian interaksi tersebut dan kemungkinan terjadinya kerusakan formasi (formation damage) sebelum pelaksanaan di lapangan. Bahkan, pada proses air formasi yang diinjeksikan kembali (recycling) masih perlu juga dilakukan analisis agar tidak terjadi kerusakan formasi.