bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Transitional Care Measures in the Prevention of Readmission After Critical Illness
Authors: Peters Jessica S.
Published: February 2017

Transitioning from the critical care unit to the medical-surgical care area is vital to patients’ recovery and resolution of critical illness. Such transitions are necessary to optimize use of available hospital resources to meet patient care needs. One in 10 patients discharged from the intensive care unit are readmitted to the unit during their hospitalization. Critical care readmission is associated with significant increases in illness acuity, overall length of stay, and health care costs as well as a potential 4-fold increased risk of mortality. Patients with complex illness, multiple comorbid conditions, and a prolonged initial stay in the critical care unit are at an increased risk of being readmitted to the critical care unit and experiencing poor outcomes. Implementing nurse-driven measures that support continuity of care and consistent communication practices such as critical care outreach services, transitional communication tools, discharge planning, and transitional care units improves transitions of patients from the critical care environment and reduces readmission rates.
Adapting transport modes to supply chains classified by the uncertainty supply chain model: A case study at Manaus Industrial Pole
Authors: Oliveira Fabiana Lucena , Oliveira Junior Aristides da Rocha , Bessa Rebelo Luiza M.
Published: February 2017

This paper discusses transport modes supporting Uncertainty Supply Chain Model (USCM) in the case of Manaus Industrial Pole (PIM), an industrial cluster in the Brazilian Amazon that hosts six hundred factories with diverse logistics and supply chain managerial strategies. USCM (Lee, 2002; Fisher, 1997)develops a dot matrix classification of the supply chains considering several attributes (e.g., agility, cost, security, responsiveness) and argues that emergent economies industrial clusters, in the effort to keep attractiveness for technological frontier firms, need to adapt supply chain strategies according to USCM attributes. The paper takes a further step, discussing which transport modes are suitable to each supply chain classified at the USCM in PIM´s case. The research´s methods covered the use of PIM´s statistical official database (secondary data), interviews with the main logistical services providers of PIM and phone survey with a sample of firms (primary data). Findings confirm the theoretical argument that different supply chains will demand different transport modes running at the same time in the same industrial cluster (Oliveira, 2009). In the case of PIM, this implies investments on port and airport infrastructure and a strategic focus on air transport mode, due to (1) short life cycle of products, (2) distance from suppliers, (3) quick response to demand and (4) the fact that even PIM´s standard products use, in average, forty per cent of air transport at inbound logistics.
Isovolumetric replacement and aeolian deposition contributed to Terrae
calcis genesis in Franconia (central Germany)
Authors: Lucke Bernhard , Kemnitz Helga , Vitzethum Stefan
Published: February 2017

Abstract. We investigated Terrae calcis on limestone and dolomite in Franconia, as well as the red fill of deep cracks in the rock (Karstschlotten). SEM images of the rock-soil transition zones supported by EDS found amorphous clays along fissures that could be products of metasomatic, authigenic clay neoformation within microfossils, calcite, and dolomite grains, or of replacing deposition of amorphous clays inside the calcite, probably due to percolating waters (illuviation). In the SEM-images, the replacement appears as exchange process characterized by substitution of Ca and Mg against Si, Al, and Fe. There is no crystalline clay deposited within rock fissures, and the transition between calcareous minerals and amorphous clay is gradual. This and the presence of Fe let it seem possible that plant roots play a major role for the transport of elements and neoformation of clays, similar to clay pavements along eucalyptus roots in Western Australia. In this context, more or less uniform Fe(d/t) ratios contradicting other weathering indicators could be the result of neoformed phyllosilicates containing Fe3+. Bulk soil and bedrock analyses indicate that the solum of the investigated Terrae calcis does mainly not represent insoluble bedrock residue. Dust deposition and bioturbation are evident due to sand grains coming from a loess surface cover, which buried pre-existing Terrae calcis and contributed to their substrate, apparently supplying quartz and clay-rich pseudosand aggregates.
Change in Frozen Soils and its Effect on Regional Hydrology in the
Upper Heihe Basin, the Northeast Qinghai-Tibetan Plateau
Authors: Gao Bing , Yang Dawen , Qin Yue , Wang Yuhan , Li Hongyi , Zhang Yanlin , Zhang Tingjun
Published: February 2017

Abstract. Frozen ground has an important role in regional hydrological cycle and ecosystem, especially on the Qinghai-Tibetan Plateau, which is characterized by high elevation and a dry climate. This study modified a distributed physically-based hydrological model and applied it to simulate the long-term (from 1961 to 2013) change of frozen ground and its effect on hydrology in the upper Heihe basin located at Northeast Qinghai-Tibetan Plateau. The model was validated carefully against data obtained from multiple ground-based observations. The model results showed that the permafrost area shrank by 9.5 % (approximately 600 km2), especially in areas with elevation between 3500 m and 3900 m. The maximum frozen depth of seasonally frozen ground decreased at a rate of approximately 4.1 cm/10 yr, and the active layer depth over the permafrost increased by about 2.2 cm/10 yr. Runoff increased significantly during cold seasons (November–March) due to the increase in liquid soil moisture caused by rising soil temperature. Areas where permafrost changed into the seasonally frozen ground at high elevation showed especially large changes in runoff. Annual runoff increased due to increased precipitation, the base flow increased due to permafrost degradation, and the actual evapotranspiration increased significantly due to increased precipitation and soil warming. The groundwater storage showed an increasing trend, which indicated that the groundwater recharge was enhanced due to the degradation of permafrost in the study area.
El "sujeto mujer": construcción cultural y reto historiográfico
Authors: Hernández Sandoica Elena
Published: February 2017

La historiografía ha puesto en marcha, a lo largo del finales del siglo XIX y durante todo el siglo XX, un poderoso andamiaje de construcción teórica y desarrollos prácticos de muy distinta entidad, cubriendo la totalidad del espectro político, cultural y social. En ese espacio múltiple, los estudios sobre mujeres y su acción, bien sea individualizada o colectiva, representan un reto que, por su incuestionable dimensión moral y política además de teórica, ya no resulta posible eludir sin deterioro para el conjunto de la profesión.
Políptico hispano-alemán con fondo de Europa en ruinas. Algunas notas sobre Alemania Occidental como referente cultural en España tras la Segunda Guerra Mundial
Authors: Sanz Díaz Carlos
Published: February 2017

Este artículo explora, con especial referencia a testimonios autobiográficos, algunos aspectos del papel que jugó Alemania Occidental como referente cultural para España después de la Segunda Guerra Mundial. Durante este periodo, la cultura alemana fue la puerta por la que una generación de jóvenes españoles formados en universidades de aquel país accedió a una cultura europea crítica. Al mismo tiempo, en la sociedad española distintos autores trataban de dotar de inteligibilidad a la experiencia alemania de posguerra.
TREINAMENTO FÍSICO NA DANÇA: REVISÃO SISTEMÁTICA SOBRE A APLICABILIDADE DO TREINAMENTO ESPORTIVO EM BAILARINOS
Authors: Becker da Silva Andressa Melina , Fiorim Enumo Sônia Regina
Published: February 2017

A preparação física do bailarino ocorre apenas com aulas específicas de dança; porém, considera-se que treinamento físico suplementar pode melhorar o desempenho de bailarinos. Objetivou-se analisar os artigos publicados sobre a temática “treinamento físico na dança” no período de 1995-2015. Após critérios de inclusão e exclusão, analisaram-se 11 artigos. Os resultados mostram que as aulas de dança não são capazes de incrementar a capacidade cardiorrespiratória e metabólica, sendo recomendados treinamentos extras, os quais comprovadamente auxiliam na amplitude de movimento, força, flexibilidade, capacidade cardiorrespiratória, medidas antropométricas e composição corporal. Um acompanhamento por educadores físicos é o ideal para uma melhora das capacidades físicas dos bailarinos.
A FORMAÇÃO SITIADA. DIRETRIZES CURRICULARES DE EDUCAÇÃO FÍSICA EM DISPUTA: JOGO JOGADO?
Authors: Castellani Filho Lino
Published: February 2017

RESUMO O presente Ensaio se insere na linha de pesquisa voltada à política educacional centrada na formação superior no âmbito da Educação Física. Nos remete ao debate de ideias e embate de compreensões acerca do que foi, é e deveria ser a formação de nível superior em Educação Física, diante das polêmicas que a acompanham desde o advento das reformas das diretrizes curriculares aventadas ao final de 1998, por conta das Diretrizes e Bases da Educação Nacional aprovada em 1996, até o atual momento, no qual a expectativa pela possível reformulação da atual diretriz vem gerando, por um lado, a ideia de que “tem jogo pela frente” e, por outro, a sensação de que o “jogo já foi jogado”.ABSTRACT The besieged formation. Curricular guidelines for Physical Education in melee: Game played? The present study is inserted in the line of research aiming for educational policies centered on higher education in the field of Physical Education. It refers to debates and discussion of ideas and understandings concerning the past, present, and the desirable future of higher education formation in Physical Education, with regard to the conflicts that have arisen since the advent of curricular guidelines in the end of 1998, following the National Education Directives and Bases Law, approved in 1996, until the present moment. The expectation for the possibility of reform of the current directives have been generating on the one hand, the idea of "the game is still on" and on the other hand, the sensation that "the game has already been played".RESUMENLa formación sitiada. Directrices curriculares de Educación Física en disputa: Juego jugado?El presente Ensayo se inserta en la línea de investigación vuelta a la política educacional centrada en la formación superior en el ámbito de la Educación Física. Nos remite al debate de ideas y embate de comprensiones acerca del que fue, es y debería ser la formación de nivel superior en Educación Física, a las polémicas que la acompañan desde la llegada de las reformas de las directrices curriculares realizadas al final de 1998, por cuenta de las Directrices y Bases de la Educación Nacional aprobada en 1996, hasta el actual momento, en el cual la expectativa por la posible refundición de la actual directriz viene generando, por un lado, la idea de que "tiene juego por el  frente" y por  otro, la sensación de que el " juego ya fue jugado".
Fatores associados a enteroparasitoses em escolares da rede municipal de ensino de Cambé
Authors: Mori Fabiana Maria Ruiz Lopes , Mitsuka-Breganó Regina , Oliveira Francisco José de Abreu , Dutra Maria Cláudia de Menezes Noronha , Sarzi Maria de Brito Lô , Aidar Marta Radigonda , Conchon-Costa Ivete
Published: February 2017

O objetivo deste trabalho foi determinar os fatores associados à prevalência das parasitoses intestinais em escolares da rede municipal de Cambé, Paraná. Foram analisadas 1996 amostras de fezes, coletadas entre 2006 e 2009, pelos métodos de Hoffmann, Pons e Janer (1934), de Faust e colaboradores e de Kato-Katz. A prevalência encontrada foi de 23,2%. Os parasitas encontrados foram Entamoeba coli (10,4%); Endolimax nana (9,6%), Giardia lamblia (6,4%), Enterobius vermicularis (1,5%), Entamoeba histolytica/dispar (0,3%), Trichuris trichiura (0,4%), Iodamoeba butschlii, Hymenolepis nana e Ancilostomídeos (0,2%) e Ascaris lumbricoides e Schistosoma mansoni (0,1%). Não houve diferença estatisticamente significativa com relação ao sexo. A faixa etária, a renda familiar, o grau de instrução da mãe, o consumo de água não tratada, a ausência de esgoto e o hábito da criança frequentar córregos apresentaram associação com a presença de enteroparasitas. Apesar da maior prevalência ser de protozoários comensais este dado é preocupante, pois indica que a transmissão fecal-oral está presente nesta população podendo ocorrer aumento na transmissão das formas patogênicas, já que estas possuem as mesmas vias de transmissão. Foram identificados casos de esquistossomose que não eram autóctones, porém o diagnóstico precoce desta infecção foi importante para se evitar a contaminação do meio ambiente.
Retinopatia da prematuridade: fatores de risco perinatais
Authors: Silva Fabiola Caroline da , Falco Helen Cristina Bruno de Barros , Silva Fernanda Grasiele da , Carvalho Paula Kossatz de
Published: February 2017

Resumo: Objetivo: Investigar os principais fatores de risco para o desenvolvimento da retinopatia da prematuridade (ROP) nos prematuros da Unidade de Terapia Intensiva (UTI) Neonatal da Santa Casa de Misericórdia de Ponta Grossa. Métodos: Estudo retrospectivo, tipo caso controle, através da revisão de prontuários entre Janeiro/2010 à Dezembro/2014. Foram incluídas crianças com peso ao nascer ?1.500 gramas, idade gestacional ?37 semanas e, excluídos portadores de malformação congênita, não submetidos à fundoscopia e os com prontuários incompletos. Os fatores de risco foram comparados com análises uni e multivarida. Para as variáveis quantitativas foi empregado o Teste t, para as qualitativas o Teste Exato de Fisher e, após análise univariada utilizou-se regressão logística. Resultados: Foram selecionados 172 neonatos, divididos em grupos: controle com 154 (89,5%) e caso com 18 (10,5%). Os fatores estudados foram: idade gestacional, peso ao nascer, APGAR 1º e 5º minuto, uso de surfactante, tempo de oxigenoterapia, fração inspirada de oxigênio (FiO2) utilizada, icterícia, necessidade de fototerapia, desenvolvimento de broncodisplasia pulmonar, enterocolite necrotizante, hemorragia intracraniana e cirurgias. Perante a análise univariada a idade gestacional, peso ao nascer, APGAR 1º e 5º minuto, tempo de oxigenoterapia, FiO2 máxima, necessidade de surfactante, tempo de início da icterícia e nível de bilirrubina indireta apresentaram significância estatística (p<0,001). Após correção com análise multivariada não se obteve p significativo. Conclusão: A frequência da ROP encontrada foi inferior à da literatura, o estadiamento III predominou, 38,9% dos prematuros com ROP grave beneficiaram-se da fotocoagulação, confirmando que identificação, triagem e tratamento precoce dos prematuros são essenciais na prevenção da cegueira.
Perfil de estudantes ingressantes de um curso de enfermagem do Sul do Brasil: caracterização dos hábitos de leitura e estudo
Authors: Garcia Aline Korki Arrabal , Moraes Aluana , Guariente Maria Helena Dantas de Menezes
Published: February 2017

O Curso de Enfermagem da Universidade Estadual de Londrina possui uma metodologia de ensino inovadora por meio do currículo integrado, baseada na problematização, sendo proposta ao aluno a busca da autonomia no estudo e o compromisso em relação aos meios de aprendizagem. Objetivou-se descrever a prática de leitura e estudo dos alunos ingressantes do curso de enfermagem da Universidade Estadual de Londrina. Trata-se de pesquisa documental, descritiva e retrospectiva com abordagem quantitativa, com egressos do curso de enfermagem. Para a coleta de dados foi utilizado questionários respondidos pelos estudantes ingressantes nos anos 2000, 2005 e 2010 no curso. Identificou-se dos 164 ingressantes que 91,5% são do sexo feminino e 97,6% solteiras, com idade entre 16 a 18 anos (45,1%). O hábito de leitura esteve presente em 81,7% dos pesquisados, sendo que 49,4% relataram apresentar facilidade na redação de textos e 57,3% facilidade parcial na interpretação de textos. Os estudantes (64%) ainda expressaram preferência por estudar sozinho, sendo a leitura silenciosa a forma de estudo mais relatada. A caracterização dos dados poderão subsidiar a gestão do curso e os professores no sentido de fomentar o desempenho acadêmico dos estudantes de enfermagem para o alcance do perfil profissional delineado
“Só o leite materno!” – significados de nutrizes sobre o aleitamento materno exclusivo
Authors: Dos-Santos Edirlei Machado , Agra Gabryelle Fernandes Araújo
Published: February 2017

Trata-se de um estudo qualitativo, exploratório e descritivo, que teve como objetivo conhecer a percepção de nutrizes sobre o aleitamento materno exclusivo. Participaram da pesquisa onze nutrizes do município de Vitória da Conquista, localizado no sudoeste baiano. Os dados foram coletados por meio de entrevistas individuais semiestruturadas e analisados por meio da Análise de Conteúdo na modalidade Temática. Foram construídas duas categorias temáticas: O aleitamento materno exclusivo na percepção de nutrizes e As potencialidades e dificuldades acerca do aleitamento materno: percepção de nutrizes. Os resultados apontaram que as nutrizes percebem a prática do aleitamento materno exclusivo como benéfica por conta do alto valor biológico que o leite materno tem para a criança, bem como evidenciaram vários fatores capazes de determinar o percurso da amamentação e, que perpassam por dimensões econômica, social, cultural e emocional.
Memórias sociais e a construção da identidade em territórios negros
Authors: MARIOSA GILMARA SANTOS
Published: February 2017

Este artigo reflete um debate sobre a relação entre territórios negros, práticas
religiosas, construção da identidade da população negra e como as memórias
e representações sociais têm influência nesse processo. As práticas religiosas
de matriz africana estão diretamente relacionadas com os referenciais
identitários da população afrodescendente. Sabemos que essas práticas são
um grande e importante legado deixado pelos africanos no Brasil para seus
descendentes, no entanto as memórias dessas práticas estão sendo marcadas
pelo esquecimento e as representações sociais ancoradas com práticas
demoníacas relacionadas ao mal. Isso faz com que os praticantes não queiram
se identificar com essas manifestações e procurem um distanciamento,
enquanto os não praticantes os veem como pessoas que praticam ações que
causam prejuízos. O resultado são atitudes de intolerância e discriminação.
Espiritualidade, religiosidade e saúde: velhos debates, novas perspectivas
Authors: Valente Tânia Cristina de Oliveira , Tavares Quelho Cássia , Rodrigues Cavalcanti Ana Paula , De Oliveira Carmo Hercules
Published: February 2017

Enquanto a religião se encontra associada ao multipluralismo cultural – com as partilhas ecumênicas e o diálogo inter-religioso – trazendo desafios que merecem espaço de discussão em nossa sociedade que, notoriamente, dá sinais de retorno ao sagrado, a Espiritualidade é sempre um assunto que chama a atenção, sendo muito discutida e valorizada, representada pelo rico mosaico simbólico que se “redescobre” a partir do discurso da Teologia, das Ciências da Religião, das Ciências Humanas, das Religiões e da Saúde. Repetidamente temos visto estes conceitos serem utilizados de forma equivalente, acarretando equívocos que podem desviar tanto a espiritualidade quanto a religiosidade de seus reais significados. Considerando a grande variedade e complexidade de definições relativas à religião e à espiritualidade, o grande desafio dessas páginas será discutir e mostrar a importância destes conceitos para o estudo de suas relações com a saúde.
Making Moves: Formative Assessment in Mathematics
Authors: Duckor Brent , Holmberg Carrie , Joanne Rossi Becker
Published: February 2017

A seventh-grade teacher finds that the notion of attention—to student and teacher thinking about student thinking—is key to orchestrating standards-based mathematical learning.
Arqueología Transmedia: participación de las audiencias en la expansión de las narrativas de la Segunda Guerra Mundial (caso Band of Brothers)
Authors: Corona Rodríguez José Manuel
Published: February 2017

Este documento pretende probar que es posible (y quizá necesario) abordar la investigación sobre lo transmedia en términos de una lógica que busque en las narrativas y relatos (del pasado y presente), aspectos trascendentes de los procesos de comunicación centrados en la participación. Se propone mover el interés de investigación desde el qué (es transmedia) hacia el cuándo (es transmedia), para demostrar que la transmedialidad en los relatos no depende únicamente de su construcción narrativa, sino de toda una organización de elementos y recursos que constituyen un conjunto de funciones que se adquieren a partir de su significación, apropiación y expansión. En este artículo se trabaja una triple articulación de lo transmedial: 1) la dimensión histórica, 2) la dimensión narrativa y 3) la relación entre la recepción y la participación, para lo que se describe y analiza la expansión ficcional y no ficcional de historias de la Segunda Guerra Mundial (tomando como ejemplo el caso de Band of Brothers). Se trabaja, desde una perspectiva crítica, la idea y posibilidad de una Arqueología Transmedia que permita expandir los límites (y usos) del concepto Transmedia Storytelling, más allá de los casos emblemáticos de la cultura popular audiovisual actual. Bajo la premisa de que la recepción nunca ha sido completamente pasiva por parte de las audiencias, se plantea la posibilidad de un tipo de recepción-participación orientada a la creación de contenidos generados por los usuarios, que se hacen visibles en universos narrativos transmediales del pasado y que pueden ser ficcionales o no.
Tunable pinning effects produced by non‐uniform antidot arrays in YBCO thin films
Authors: George J. , Jones A. , Al‐Qurainy M. , Fedoseev S. A. , Rosenfeld A. , Pan A. V.
Published: February 2017

Uniform, graded and spaced arrays of 3 μm triangular antidots in pulsed laser deposited YBa2Cu3O7 (YBCO) superconducting thin films are compared by examining the improvements in the critical current density they produced. The comparison is made to establish the role of their lithographically defined (non‐)uniformity and the effectiveness to control and/or enhance the critical current density. It is found that almost all types of non‐uniform arrays, including graded ones enhance over the broad applied magnetic field and temperature range due to the modified critical state. Whereas uniform arrays of antidots either reduce or produce no effect on compared to the original (as‐deposited) thin films.

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Pharmacokinetics and protein binding of MPT0B292
Authors: Tien Yu‐En , Li Chan‐Jung , Liou Jing‐Ping , Chang Jang‐Yang , Huang Jin‐Ding
Published: February 2017

MPT0B292 was identified through screening of compounds able selectively to acetylate α‐tubulins in cells and it exhibited potent anti‐tumor, anti‐angiogenesis and anti‐metastatic effects in vitro and in vivo. Because of its poor water solubility, MPT0B292 is difficult to formulate with conventional approaches and hence difficulties are experienced in research practices. MPT0B292 was mixed with albumin in an aqueous solvent to form drug albumin nanoparticles with a size range around 333 nm. Unbound fractions of these nanoparticles were investigated in different or the same albumin concentration solutions. Unlike most drugs, the binding of MPT0B292 in human serum albumin increased with increasing drug concentrations. An analytical method was also developed and validated to determine MPT0B292 in rat plasma. This analytical method was applied successfully to the intravenous pharmacokinetic study of MPT0B292 in rats. A single dose study was regularly done to characterize the pharmacokinetic properties of the drug. Additionally, a novel i.v. infusion study was carried out to verify the extraction ratio of MPT0B292. The pharmacokinetic analysis revealed that MPT0B292 was a high extraction ratio drug with high systemic clearance, a high volume of distribution and a short half‐life in rats. Copyright © 2017 John Wiley & Sons, Ltd.
Device‐associated thrombus formation after left atrial appendage occlusion: A systematic review of events reported with the Watchman, the Amplatzer Cardiac Plug and the Amulet
Authors: Lempereur Mathieu , Aminian Adel , Freixa Xavier , Gafoor Sameer , Kefer Joelle , Tzikas Apostolos , Legrand Victor , Saw Jacqueline
Published: February 2017

Objectives

This study aimed to provide a systematic review of device‐associated thrombosis (DAT) after left atrial appendage occlusion (LAAO) with the Watchman, Amplatzer Cardiac Plug, and Amulet devices.

Background

DAT is known as a complication of LAAO but data about its clinical impact is scarce.

Methods

A systematic review of studies evaluating the incidence, treatment and clinical implications of DAT from January 2008 to September 2015 was conducted.

Results

A total of 30 studies describing DAT events were included in the analysis. The overall incidence of DAT was 3.9% (82 DAT for 2118 implanted devices). The median time from procedure to diagnosis of DAT was 1.5 months (IQR: 0–2.9). Most cases were diagnosed with transesophageal echocardiogram (TEE). The treatment consisted of low molecular weight heparin (LMWH) in 45.5% of cases, and oral anticoagulation (OAC) or other treatment modalities in 54.5%. Complete thrombus resolution was achieved in 95.0% of cases (100% with LMWH and 89.5% with OAC). Treatment duration varied greatly with a median treatment duration of 45 days (IQR: 14–135). Clinical events related to DAT consisted of neurologic events namely two transient ischemic attacks (2.4%) and four ischemic strokes (4.9%).

Conclusions

DAT is an infrequent complication of percutaneous LAAO. It occurs mainly early after the procedure and is associated with a low rate of neurological complications. In the majority of cases, diagnosis is made during follow‐up imaging with TEE. Anticoagulation treatment seems to be safe and highly effective. Further studies are needed to evaluate the optimal management of DAT. © 2017 Wiley Periodicals, Inc.
Clinical outcomes after trans‐catheter aortic valve replacement in men and women in Ontario, Canada
Authors: Czarnecki Andrew , Qiu Feng , Koh Maria , Prasad Treesa J. , Cantor Warren J. , Cheema Asim N. , Chu Michael W.A. , Feindel Christopher , Fremes Stephen E. , Kingsbury Kori , Natarajan Madhu K. , Peterson Mark D. , Ruel Marc , Strauss Bradley H. , Wijeysundera Harindra C. , Ko Dennis T.
Published: February 2017

Objective

Our objective was to evaluate sex‐differences in outcomes after trans‐catheter aortic valve replacement (TAVR) in a population‐based cohort from Ontario, Canada.

Background

Prior studies comparing outcomes in men and women after TAVR have yielded divergent results. Some studies have suggested that women have better survival than men while others have not corroborated this finding.

Methods

A retrospective observational cohort study was conducted using chart abstraction data on all TAVR procedures performed between 2007 and 2013 in Ontario, Canada. Patients who had emergency TAVR procedures were excluded. The primary outcome was all‐cause mortality at 30‐days and 1‐year. Secondary outcomes included mortality at last follow‐up, cause‐specific, and all‐cause hospital readmission. Inverse probability of treatment weighting (IPTW) using propensity score was used to adjust for baseline differences between men and women.

Results

The final study cohort consisted of 453 women and 546 men with a mean follow‐up of 3.5 years. Women were generally older and more frail but had less comorbid conditions. Women had lower unadjusted mean EuroScores (7% ± 5% vs 8% ± 7%; P = 0.008), but underwent significantly more trans‐apical procedures (26.5% vs 19.2%; P = 0.006) than men. After IPTW, the groups were well balanced. Although mortality was numerically higher for women at 30‐days (7.2% vs 5.4%), this was not statistically significant (P = 0.34). At 1‐year, there was no difference in mortality (18.2% vs 19.2%; P = 0.85). There were no significant differences in all‐cause readmission.

Conclusion

In this population‐based cohort including all patients undergoing TAVR, mortality or all‐cause readmission were not significantly different between men and women. © 2017 Wiley Periodicals, Inc.
Evaluation of clinical outcomes after COMBO stent treatment in patients presenting with acute coronary syndrome
Authors: Kalkman Deborah N. , Woudstra Pier , Lu Huangling , Menown Ian B.A. , den Heijer Peter , Suryapranata Harry , Iñiguez Andrés , Arkenbout Karin E. , van't Hof Arnoud W.J. , Muller Philippe , Erglis Andrejs , Tijssen Jan G. , Beijk Marcel A.M. , de Winter Robbert J.
Published: February 2017

Background

Patients presenting with acute coronary syndrome (ACS) are at increased risk of complications after percutaneous coronary intervention with stent placement compared to patients with stable angina (SA) treated in an elective setting. The novel pro‐healing COMBO stent is a bio‐engineered drug eluting stent designed to promote vessel healing. Therefore, the stent may reduce this difference in clinical outcomes between elective and ACS‐patients and prevent late stent thrombosis.

Methods and Results

The European, prospective, multicenter, 1000 all‐comers patient REMEDEE registry evaluates clinical outcomes after COMBO stent placement in ACS‐ and elective patients. The primary endpoint at 12 months is target lesion failure (TLF), a composite of cardiac death, target‐vessel myocardial infarction and target lesion revascularization. A total of 49.9% (n = 498) of patients presented with acute coronary syndrome. TLF was 7.1% in ACS patients, definite and probable stent thrombosis was observed in 0.5% of ACS patients and in all within 9 days post stenting. We found no significant difference in TLF between ACS and non‐ACS patients and a low overall rate of TLF.

Conclusions

The COMBO stent is a safe and efficient device for patients presenting with ACS. Low ST rate and only early stent thrombosis were observed. © 2017 Wiley Periodicals, Inc.
Macrocyclic Oligothiophene with Stereogenic [2.2]Paracyclophane Scaffolds: Chiroptical Properties from π‐Transannular Interactions
Authors: Hasegawa Masashi , Kobayakawa Kosuke , Matsuzawa Hideyo , Nishinaga Tohru , Hirose Takashi , Sako Katsuya , Mazaki Yasuhiro
Published: February 2017

The enantiomers of a new cyclic oligothiophene, bridged by two pseudo‐ortho[2.2]paracyclophanes, were synthesized as a new class of the chiral π‐conjugated system. Single‐crystal X‐ray diffraction analysis revealed a twisted structure for these oligothiophenes induced by a torsion of the cyclophane moieties. The embedding oligothiophenes into the inherent planar chirality provided a significant enhancement in circular dichroism (CD) spectra thanks to the large magnetic/electric transition dipole moments. In the dicationic state, an intramolecular π dimer was formed due to the strong interactions of the oligothiophenes. We further recorded unprecedented wide ranges of CD spectra in 250–1800 nm region. The transitions are reasonably described by the exciton coupling of the oligothiophenes.
Neuroendocrine liver metastasis: The chance to be cured after liver surgery
Authors: Bagante Fabio , Spolverato Gaya , Merath Katiuscha , Postlewait Lauren McLendon , Poultsides George A. , Mullen Matthew G. , Bauer Todd W. , Fields Ryan C. , Lamelas Jorge , Marques Hugo P. , Aldrighetti Luca , Tran Thuy , Maithel Shishir K. , Pawlik Timothy M.
Published: February 2017

Background and Objective

Neuroendocrine liver metastasis tumors (NELM) are a heterogeneous group of neoplasms with varied histologic features and a wide range of clinical behaviors. We aimed to identify the fraction of patients cured after liver surgery for NELM.

Methods

Cure fraction models were used to analyze 376 patients who underwent hepatectomy with curative intent for NELM.

Results

The median and 5‐year disease‐free survival (DFS) were 4.5 years and 46%, respectively. The probability of being cured from NELM by liver surgery was 44%; the time to cure was 5.1 years. In a multivariable cure model, type of neuroendocrine tumor (NET), grade of tumor differentiation, and rate of liver involvement resulted as independent predictors of cure. The cure fraction for patients with well differentiated NELM from gastrointestinal NET or a functional pancreatic NET, and with <50% of liver‐involvement was 95%. Patients who had moderately/poorly differentiated NELM from a non‐functional pancreatic NET, and with <50% of liver‐involvement was 43%. In the presence of all the three unfavorable prognostic factors (nonfunctional PNET, liver involvement >50%, moderately/poorly differentiation), the cure fraction was 8%.

Conclusions

Statistical cure after surgery for NELM is possible, and allow for a more accurate prediction of long‐term outcome among patients with NELM undergoing liver resection.
When Banks Lobby: The Effects of Organizational Characteristics and Banking Regulations on International Bank Lobbying
Authors: Chalmers Adam William
Published: February 2017

This article examines bank lobbying in the Basel Committee on Banking Supervision (BCBS). While excessive bank lobbying is routinely linked to weakened banking regulations, we still know little about bank mobilization patterns. In particular, when and why do some banks lobby the BCBS while others do not? I argue that the decision to lobby is a function of two factors: banks’ organizational characteristics and domestic banking regulations. I test my argument using a unique dataset of over 33,000 banks worldwide during the period in which Basel III was negotiated. My findings confirm a pronounced bias in bank mobilization patterns toward wealthy, internationally active banks. I also find that banks facing more stringent banking regulations at home tend to lobby the BCBS in an effort to level the playing field with international competitors. This effect is particularly salient for stringent regulations on banking activities as well as higher capital adequacy requirements.1
Campanian and Maastrichtian plagioptychid rudists (Hippuritida, Bivalvia) of the Chiapas Central Depression, southern Mexico
Authors: Pons Jose Maria , Vicens Enric , García-Barrera Pedro
Published: February 2017

Plagioptychids are a conspicuous, although minor, component in uppermost Cretaceous rudist-bearing outcrops of the Caribbean Province, where other rudist families are more abundant and diverse. In the Chiapas Central Depression, the plagioptychid rudist fauna includes the following taxa: Plagioptychus antillarum (Douvillé) and Mitrocaprina sp. from the middle Campanian Suchiapa Formation, Plagioptychus muellerriedi Alencáster from the early Maastrichtian Ocozocoautla Formation, and Plagioptychus fragilis Chubb and Mitrocaprina tschoppi (Palmer) from the late Maastrichtian Angostura Formation. These five species are described in detail and some probable synonymies are discussed. Analysis of the literature on American plagioptychids reveals that the characters of too many taxa are still insufficiently known to attempt any thorough phylogenetic analysis. Other lines of evidence also seem to indicate that American Plagioptychidae diversity is probably higher than recognized today, which might result in a more significant difference to Plagioptychidae of the Mediterranean Tethys.
Absolute equation of state measurement of aluminum using laser quasi-isentropic-driven flyer plate
Authors: Shu H. , Huang X. , Ye J. , Jia G. , Wu J. , Fu S.
Published: February 2017

In this paper, we perform an absolute equation of state (EOS) measurement on the principal Hugoniot of aluminum using a near-symmetric impact method. The flyer plates are accelerated to high velocities using the laser-ramp-driven method. An aluminum flyer plate of ~25 µm is accelerated to the velocity range from 4 to 12 km/s. Then the aluminum flyer plate propagates across a vacuum gap and impacts with an aluminum step target. A line-imaging optical recording velocity interferometer for any reflector (ORVIS) is used to measure the aluminum flyer plate and the shock velocity simultaneously. Aluminum EOS data were measured with pressures range from 50 to 200 GPa. This absolute EOS measurement method may be used for studying a variety of materials.
Interactive effects of MnO2, organic matter and pH on abiotic formation of N2O from hydroxylamine in artificial soil mixtures
Authors: Liu Shurong , Berns Anne E. , Vereecken Harry , Wu Di , Brüggemann Nicolas
Published: February 2017

Abiotic conversion of the reactive nitrification intermediate hydroxylamine (NH2OH) to nitrous oxide (N2O) is a possible mechanism of N2O formation during nitrification. Previous research has demonstrated that manganese dioxide (MnO2) and organic matter (OM) content of soil as well as soil pH are important control variables of N2O formation in the soil. But until now, their combined effect on abiotic N2O formation from NH2OH has not been quantified. Here, we present results from a full-factorial experiment with artificial soil mixtures at five different levels of pH, MnO2 and OM, respectively, and quantified the interactive effects of the three variables on the NH2OH-to-N2O conversion ratio (RNH2OH-to-N2O). Furthermore, the effect of OM quality on RNH2OH-to-N2O was determined by the addition of four different organic materials with different C/N ratios to the artificial soil mixtures. The experiments revealed a strong interactive effect of soil pH, MnO2 and OM on RNH2OH-to-N2O. In general, increasing MnO2 and decreasing pH increased RNH2OH-to-N2O, while increasing OM content was associated with a decrease in RNH2OH-to-N2O. Organic matter quality also affected RNH2OH-to-N2O. However, this effect was not a function of C/N ratio, but was rather related to differences in the dominating functional groups between the different organic materials.
Comparison of amino acid profiles and metabolic gene expression in muskrat scented glands in secretion and non-secretion season
Authors: Li Yimeng , Zhang Tianxiang , Fan Mengyuan , Zhou Juntong , Yang Shuang , Zhang Meishan , Qi Lei , Lin Shaobi , Hu Defu , Liu Shuqiang
Published: February 2017

The scented gland is an organ responsible for producing musk in muskrats. During musk secretion season, the metabolism of glandular cells increases in the scented glands and a large amount of musk is synthesised. In this study, we collected scented gland arterial blood from six healthy adult male muskrats during non-secretion season (November). We also obtained scented gland arterial blood, venous blood, and musk from six healthy adult males during secretion season (March). Qualitative and quantitative analyses of free amino acids in blood and musk were performed with an automated amino acid analyzer. Additionally, we employed RNA sequencing technology to study the expression patterns of amino acid metabolic pathways in scented glands. Amino acid profile analysis indicates that scented glands can concentrate amino acids during secretion season, and transcriptome analysis suggests that some amino acid metabolism-related genes undergo significant seasonal changes. In summary, scented gland amino acid metabolism displays seasonal differences. Elevated amino acid metabolic activity during secretion season sustains the glands’ secretory function.
Attentional deployment impacts neural response to regret
Authors: Liu Zhiyuan , Li Lin , Zheng Li , Xu Min , Zhou Fanzhi Anita , Guo Xiuyan
Published: February 2017

Regret results from comparing non-optimal outcomes containing both gain and loss parts to better alternatives during decision-making. The present fMRI study aimed to explore whether levels of regret could change when gain or loss part of a non-optimal outcome was focused during a sequential risk taking task, i.e. the effect of an important emotional regulation strategy named as attentional deployment on regret. Participants were asked to open a series of boxes consecutively and decided when to stop. Each box contained a reward, except for one containing a devil to zero one’s gain in the trial. After participants stopped, both collected gains and missed chances were revealed. Besides, participants were induced to focus on collected gains (GF) or missed chances (MF), by highlighting different parts of the outcome with red squares. Behaviorally, participants rated less regret to their decisions in GF than MF context. Moreover, participants tended to be less risk-taking after GF context relative to MF. At the neural level, bilateral straitum showed increased activations in both optimal outcome and GF context. However, right MFG and IPL only showed stronger activation in GF than MF context. Additionally, pgACC and mPFC activations were found only in optimal outcome.
Evidence-Based Practices and Teaching NonVerbal Pragmatic Skills to Adolescents With ASD: Lessons Learned From Parent Perspective and Brain Research
Authors: Lynch Georgina
Published: February 2017

As a growing population with Autism spectrum disorder (ASD) leaves the K-12 educational system and enters the workforce and college settings, long-term outcomes inform the need for further development of social skills interventions promoting success in these new contexts. Drawing from neuroscience literature describing neuropathology of ASD over the lifespan, physiologic deficits have been documented which impact nonverbal pragmatics, informing development of new treatments for those on the spectrum representing high-functioning autism. Nonverbal language skills warrants focused intervention to promote greater success in the workplace and college, and are directly influenced by the visual pathway, known to be atypical within ASD. Parent perspective offers insight about deficiencies in nonverbal skills which persist into early adulthood, in line with brain imaging data indicating a decline in adaptive skills and socialization. Evidence-based practices (EBP) for treating adolescents with ASD by targeting visual attention and pragmatics are presented. New insights are offered about how to integrate knowledge of brain function within targeted language therapy approaches emphasizing visual teaching. Empirical evidence is provided guiding future clinical research supporting the need for continued language intervention into late adolescence and early adulthood.
Directional interpolation of multicomponent data
Authors: Andersson Fredrik , Ramírez Adriana Citlali , Wiik Torgeir , Nikitin Viktor V.
Published: February 2017

A method for interpolation of multicomponent streamer data based on using the local directionality structure is presented. The derivative components are used to estimate a vector field that locally describes the direction with the least variability. Given this vector field, the interpolation can be phrased in terms of the solution of a partial differential equation that describes how energy is transported between regions of missing data. The approach can be efficiently implemented using readily available routines for computer graphics. The method is robust to noise in the measurements and particularly towards high levels of low‐frequent noise that is present in the derivative components of the multicomponent streamer data.
Responsibility talk in short Finnish texts on personal wellbeing
Authors: Tuohimaa Hanna
Published: February 2017

Responsibility is a concept with multiple meanings and uses. In relation to wellbeing, it may be used, for example, to define causal agency or taking charge, as well as to define liability and moral obligations to lead a specific lifestyle. In addition, the same issues may also be discussed without using the responsibility concept at all. In this sense, responsibility talk expands beyond the concept and may be seen as a compilation of discourses circling around the concept from different perspectives.

In this article, 72 short texts written about personal wellbeing for a Finnish writing competition in 2010 were analysed in order to evaluate how the authors discuss responsibility. The analysis shows that an accountability‐ and blame‐oriented public debate on health and wellbeing is identified by many of the authors in the data. However, for the authors, being responsible mainly means listening to oneself, making decisions and choosing what is good for oneself and for one's loved ones, irrespective of outside pressure to act otherwise. This positively toned definition of responsibility provides a viable starting point for discussing wellbeing in the public domains. Yet the negative connotations also need to be acknowledged. Overall, more theorising and research are still needed.
Views of patient, healthcare professionals and administrative staff on flow of information and collaboration in a regional health information exchange: a qualitative study
Authors: Mäenpää Tiina , Asikainen Paula , Suominen Tarja
Published: February 2017

Background

Nowadays, patients can be more involved in developing healthcare services with their healthcare professionals. Patient‐centred information is a key part of improving regional health information exchange (HIE), giving patients an active role in care management.

Aim

The aim was to get a deeper understanding of the flow of information and collaboration in one hospital district area from the viewpoint of patients, healthcare professionals and administrative staff.

Methods

The data were collected by themed interviews and analysed using both deductive and inductive content analyses. The interview themes were the flow of information and collaboration after 5 years of HIE usage in one hospital district area in Finland.

Findings

Health information exchange usage had changed the regional flow of information after the 5‐year period. The patients were satisfied that their primary care physician was able to access their special care information. The experiences of healthcare professionals and administrative staff also showed that information availability and information exchange had improved regionally. HIE usage was also found to have improved regional collaboration between different organisations in patient health care.

Conclusions

It was recognised that patients had taken on more responsibility for transferring their follow‐up treatment information. Healthcare information exchange between professionals not only improves patient care or patient involvement in their own care, but it also requires that patient self‐care or self‐care management is integrated into HIE systems to share information not only among professionals, but also between patients and professionals. This information will be used in the development of healthcare systems to meet more the developing of the continuity of care the patient's point of view.
Examining The Influence Of Social Support and Mentoring On Entrepreneurial Quality Among Graduate Entrepreneurs
Authors: Abd Rani Shamsul Huda , Abd Hamid Siti Norasyikin , Mustafa Kamil Bidayatul Akmal
Published: February 2017

This study investigates the influence of social support and mentoring on entrepreneurial quality among graduate entrepreneurs. In order to gain sustainable growth, entrepreneurial quality is viewed as a crucial factor which affects the business potential such as in overcoming barriers as well as increasing the business survival (Darroch & Clover 2005). Entrepreneurial quality is essential in increasing the competitiveness of regional economy, not only the competitiveness of the entrepreneurs themselves (Cumplido & Alcalde 2002).  Partial Least Square (PLS) Structural Equation Modeling  (SEM) is used to test the relationship between constructs. The findings revealed that social support and mentoring influenced the development of entrepreneurial quality among graduate entrepreneurs.
The new EFSUMB Guidelines on Liver Elastography 2017: why and for whom?
Authors: Sporea Ioan
Published: February 2017

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