bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcriptomic Analysis Reveals the Impact of the Biopesticide Metarhizium anisopliae on the Immune System of Major Workers in Solenopsis invicta
Authors: Wu Hongxin , Xu Yating , Zafar Junaid , Mandal Surajit De , Lin Liangjie , Lu Yongyue , Jin Fengliang , Pang Rui , Xu Xiaoxia
Published: August 2023

The red imported fire ant (Solenopsis invicta Buren, 1972) is a globally significant invasive species, causing extensive agricultural, human health, and biodiversity damage amounting to billions of dollars worldwide. The pathogenic fungus Metarhizium anisopliae (Metchnikoff) Sorokin (1883), widely distributed in natural environments, has been used to control S. invicta populations. However, the interaction between M. anisopliae and the immune system of the social insect S. invicta remains poorly understood. In this study, we employed RNA-seq to investigate the effects of M. anisopliae on the immune systems of S. invicta at different time points (0, 6, 24, and 48 h). A total of 1313 differentially expressed genes (DEGs) were identified and classified into 12 expression profiles using short time-series expression miner (STEM) for analysis. Weighted gene co-expression network analysis (WGCNA) was employed to partition all genes into 21 gene modules. Upon analyzing the statistically significant WGCNA model and conducting Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis on the modules, we identified key immune pathways, including the Toll and Imd signaling pathways, lysosomes, autophagy, and phagosomes, which may collectively contribute to S. invicta defense against M. anisopliae infection. Subsequently, we conducted a comprehensive scan of all differentially expressed genes and identified 33 immune-related genes, encompassing various aspects such as recognition, signal transduction, and effector gene expression. Furthermore, by integrating the significant gene modules derived from the WGCNA analysis, we constructed illustrative pathway diagrams depicting the Toll and Imd signaling pathways. Overall, our research findings demonstrated that M. anisopliae suppressed the immune response of S. invicta during the early stages while stimulating its immune response at later stages, making it a potential biopesticide for controlling S. invicta populations. These discoveries lay the foundation for further understanding the immune mechanisms of S. invicta and the molecular mechanisms underlying its response to M. anisopliae.
Anthropogenic Influence on Moth Populations: A Comparative Study in Southern Sweden
Authors: Franzén Markus , Forsman Anders , Karimi Bafraw
Published: August 2023

As moths are vital components of ecosystems and serve as important bioindicators, understanding the dynamics of their communities and the factors influencing these dynamics, such as anthropogenic impacts, is crucial to understand the ecological processes. Our study focuses on two provinces in southern Sweden, Västergötland and Småland, where we used province records from 1974 to 2019 in combination with light traps (in 2020) to record the presence and abundance of moth species, subsequently assessing species traits to determine potential associations with their presence in anthropogenically modified landscapes. This study design provides a unique opportunity to assess temporal changes in moth communities and their responses to shifts in environmental conditions, including anthropogenic impacts. Across the Västergötland and Småland provinces in Sweden, we recorded 776 moth taxa belonging to fourteen different taxonomic families of mainly Macroheterocera. We captured 44% and 28% of the total moth species known from these provinces in our traps in Borås (Västergötland) and Kalmar (Småland), respectively. In 2020, the species richness and abundance were higher in Borås than in Kalmar, while the Shannon and Simpson diversity indices revealed a higher species diversity in Kalmar. Between 1974 and 2019, the colonisation rates of the provinces increased faster in Småland. Ninety-three species were found to have colonised these provinces since 1974, showing that species richness increased over the study period. We reveal significant associations between the probability of a species being present in the traps and distinct traits compared to a provincial species pool. Traits over-represented in the traps included species with a high variation in colour patterns, generalist habitat preferences, extended flight periods, lower host plant specificity, and overwintering primarily as eggs. Our findings underscore the ongoing ecological filtering that favours certain species-specific traits. This study sheds light on the roles of climate change and anthropogenic impacts in shaping moth biodiversity, offers key insights into the ecological processes involved, and can guide future conservation efforts.
Continuum Logic of Control Signals in Analog Cyber–Physical Nets
Authors: Dembitsky Nikolay
Published: August 2023

The use of embedded processors is the most promising direction in the development of automatic control systems. The article is devoted to analog models and technical solutions that allow continuous analysis of information in a technical system in order to synthesize control signals. Technical solutions are obtained on the basis of continuum logic methods, which aim to increase the speed of embedded computing networks, reduce power consumption, and unify the element base of analog processors. The effect of high speed is achieved due to the transition from sequential digital calculations to parallel synthesis of analog control signals. Examples of the implementation of schemes for the synthesis of control commands using the developed models of logical operations are given.
A Comparative Assessment of Homomorphic Encryption Algorithms Applied to Biometric Information
Authors: Crihan Georgiana , Crăciun Marian , Dumitriu Luminița
Published: August 2023

This paper provides preliminary research regarding the implementation and evaluation of a hybrid mechanism of authentication based on fingerprint recognition interconnected with RFID technology, using Arduino modules, that can be deployed in different scenarios, including secret classified networks. To improve security, increase efficiency, and enhance convenience in the process of authentication, we perform a comparative assessment between two homomorphic encryption algorithms, the Paillier partial homomorphic algorithm and the Brakerski–Gentry–Vaikuntanathan fully homomorphic encryption scheme, applied to biometric templates extracted from the device mentioned above, by analyzing factors such as a histogram analysis, mean squared error (MSE), peak signal-to-noise ratio (PSNR), the structural similarity index measure (SSIM), the number of pixel change rate (NPCR), the unified average changing intensity (UACI), the correlation coefficient, and average encryption time and dimension. From security and privacy perspectives, the present findings suggest that the designed mechanism represents a reliable and low-cost authentication alternative that can facilitate secure access to computer systems and networks and minimize the risk of unauthorized access.
Recent Inventions in Additive Manufacturing: Holistic Review
Authors: Fidan Ismail , Huseynov Orkhan , Ali Mohammad Alshaikh , Alkunte Suhas , Rajeshirke Mithila , Gupta Ankit , Hasanov Seymur , Tantawi Khalid , Yasa Evren , Yilmaz Oguzhan , Loy Jennifer , Popov Vladimir , Sharma Ankit
Published: August 2023

This general review paper presents a condensed view of recent inventions in the Additive Manufacturing (AM) field. It outlines factors affecting the development and commercialization of inventions via research collaboration and discusses breakthroughs in materials and AM technologies and their integration with emerging technologies. The paper explores the impact of AM across various sectors, including the aerospace, automotive, healthcare, food, and construction industries, since the 1970s. It also addresses challenges and future directions, such as hybrid manufacturing and bio-printing, along with socio-economic and environmental implications. This collaborative study provides a concise understanding of the latest inventions in AM, offering valuable insights for researchers, practitioners, and decision makers in diverse industries and institutions.
Characteristics, Treatment Strategies and Outcome in Cardiogenic Shock Complicating Acute Myocardial Infarction: A Contemporary Dutch Cohort
Authors: Peters Elma J. , Berg Sanne ten , Bogerd Margriet , Timmermans Marijke J. C. , Kraaijeveld Adriaan O. , Bunge Jeroen J. H. , Teeuwen Koen , Lipsic Erik , Sjauw Krischan D. , Geuns Robert-Jan M. van , Dedic Admir , Dubois Eric A. , Meuwissen Martijn , Danse Peter , Verouden Niels J. W. , Bleeker Gabe , Cabezas José M. Montero , Ferreira Irlando A. , Engström Annemarie E. , Lagrand Wim K. , Otterspoor Luuk C. , Vlaar Alexander P. J. , Henriques José P. S. ,   on behalf of the Participating Centers of the PCI Registration Committee of the Netherlands Heart Registration
Published: August 2023

Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) is associated with high morbidity and mortality. Our study aimed to gain insights into patient characteristics, outcomes and treatment strategies in CS patients. Patients with CS who underwent percutaneous coronary intervention (PCI) between 2017 and 2021 were identified in a nationwide registry. Data on medical history, laboratory values, angiographic features and outcomes were retrospectively assessed. A total of 2328 patients with a mean age of 66 years and of whom 73% were male, were included. Mortality at 30 days was 39% for the entire cohort. Non-survivors presented with a lower mean blood pressure and increased heart rate, blood lactate and blood glucose levels (p-value for all <0.001). Also, an increased prevalence of diabetes, multivessel coronary artery disease and a prior coronary event were found. Of all patients, 24% received mechanical circulatory support, of which the majority was via intra-aortic balloon pumps (IABPs). Furthermore, 79% of patients were treated with at least one vasoactive agent, and multivessel PCI was performed in 28%. In conclusion, a large set of hemodynamic, biochemical and patient-related characteristics was identified to be associated with mortality. Interestingly, multivessel PCI and IABPs were frequently applied despite a lack of evidence.
Total Rehabilitation Using Adhesive Dental Restorations in Patients with Severe Tooth Wear: A 5-Year Retrospective Case Series Study
Authors: Ferrando Cascales Álvaro , Sauro Salvatore , Hirata Ronaldo , Astudillo-Rubio Daniela , Ferrando Cascales Raúl , Agustín-Panadero Rubén , Delgado-Gaete Andrés
Published: August 2023

Introduction: Currently, there is little clinical evidence to support the medium- and long-term survival and clinical performance of ultraconservative approaches using adhesive restorations in full-mouth restorations. The aim of this case series study was to evaluate the medium-term clinical performance of anterior and posterior adhesive restorations applied with direct and indirect techniques using resin composites and glass-ceramic-based materials. Materials and Methods: The inclusion criteria were an esthetic problem as the main reason for consultation and severe generalized wear of grade 2 to 4 according to the Tooth Wear Evaluation System (TWES 2.0). In addition, at each follow-up appointment, patients were required to submit a clinical-parameter-monitoring record according to the modified United States Public Health Service (USPHS) criteria. Results: Eight patients with severe tooth wear were treated through full rehabilitation in a private dental clinic in Spain by a single operator (AFC). A total of 212 restorations were performed, which were distributed as follows: 66 occlusal veneers, 26 palatal veneers and 120 vestibular veneers. No signs of marginal microleakage or postoperative sensitivity were observed in any occlusal, vestibular and/or palatal restoration after the follow-up period. The estimated survival rate of the 212 restorations was 90.1% over 60 months of observation, with a survival time of 57.6 months. Only 21 restorations had complications, which were mostly resolved with a direct composite resin. The dichotomous variables of the restoration type (posterior veneer, anterior veneer) and the type of restored tooth (anterior, posterior) were the risk predictors with statistically significant influences (p < 0.005) on the survival of the restorations. Conclusion: According to the results of this study, there is a significantly higher risk of restorative complications in posterior teeth compared to anterior teeth. Also, it can be concluded that the indication of adhesive anterior and posterior restorations is justified in the total oral rehabilitation of patients with severe multifactorial tooth wear, as they are associated with a low risk of failure.
Unraveling Acute and Post-COVID Cytokine Patterns to Anticipate Future Challenges
Authors: Bekbossynova Makhabbat , Tauekelova Ainur , Sailybayeva Aliya , Kozhakhmetov Samat , Mussabay Karakoz , Chulenbayeva Laura , Kossumov Alibek , Khassenbekova Zhanagul , Vinogradova Elizaveta , Kushugulova Almagul
Published: August 2023

The aims of this study were to analyze cytokine profiles in patients with COVID-19, gain insights into the immune response during acute infection, identify cytokines associated with disease severity and post-COVID complications, and explore potential biomarkers for prognosis and therapeutic targets. Using a multiplex analysis, we studied the cytokine pattern in 294 acute COVID-19 and post-COVID patients with varying severities of infection. Our findings revealed that disease severity was associated with elevated levels of IL-15, IL-8, and fractalkine. Severe/extremely severe forms in comparison with mild/moderate disease were associated with MCP-1, IFNa2, IL-7, IL-15, EGF, IP-10, IL-8, Eotaxin, FGF-2, GROa, sCD40L, and IL-10. The key cytokines of post-COVID are FGF-2, VEGF-A, EGF, IL-12(p70), IL-13, and IL-6. By the sixth month after recovering from a coronavirus infection, regardless of disease severity, some patients may develop complications such as arterial hypertension, type 2 diabetes mellitus, glucose intolerance, thyrotoxicosis, atherosclerosis, and rapid progression of previously diagnosed conditions. Each complication is characterized by distinct cytokine profiles. Importantly, these complications can also be predicted during the acute phase of the coronavirus infection. Understanding cytokine patterns can aid in predicting disease progression, identifying high-risk patients, and developing targeted interventions to improve the outcomes of COVID-19.
Real-Time Estimation of Anaerobic Threshold during Exercise Using Electrocardiogram in Heart Failure Patients
Authors: Ryuzaki Toshinobu , Shiraishi Yasuyuki , Miura Kotaro , Ikura Hidehiko , Seki Yuta , Azuma Koichiro , Sato Kazuki , Fukuda Keiichi , Katsumata Yoshinori
Published: August 2023

Exercise therapy at the aerobic level is highly recommended to improve clinical outcomes in patients with heart failure, in which cardiopulmonary exercise testing (CPX) is required to determine anaerobic thresholds (ATs) but is not available everywhere. This study aimed to validate a method to estimate the AT using heart rate variability (HRV) analysis from electrocardiography data in patients with heart failure. Between 2014 and 2019, 67 patients with symptomatic heart failure underwent CPXs in a single university hospital. During the CPX, RR intervals was measured continuously and the HRV threshold (HRVT), defined as the inflection point of <5 ms2 of a high-frequency component (HFC) using the power spectrum analysis, was determined. Patients were divided into two groups according to the mean HFC at rest (high-HFC group, n = 34 and low-HFC group, n = 33). The high-HFC group showed good correlation between the VO2 at AT and HRVT (r = 0.63, p < 0.001) and strong agreement (mean difference, −0.38 mL/kg, p = 0.571). The low-HFC group also showed modest correlation (r = 0.41, p = 0.017) but poor agreement (mean differences, 3.75 mL/kg, p < 0.001). In conclusion, the HRVT obtained from electrocardiography may be a useful indicator for estimating AT in patients with heart failure.
Use of the Free Endometriosis Risk Advisor App as a Non-Invasive Screening Test for Endometriosis in Patients with Chronic Pelvic Pain and/or Unexplained Infertility
Authors: Nezhat Camran , Armani Ellie , Chen Hsuan-Chih Carolina , Najmi Zahra , Lindheim Steven R. , Nezhat Ceana
Published: August 2023

Endometriosis is a prevalent condition that affects millions of individuals globally, leading to various symptoms and significant disruptions to their quality of life. However, the diagnosis of endometriosis often encounters delays, emphasizing the pressing need for non-invasive screening. This retrospective cross-sectional study aimed to evaluate the utility of the Endometriosis Risk Advisor (EndoRA) mobile application in screening for endometriosis in patients with chronic pelvic pain and/or unexplained infertility. The study consisted of 293 patients who met specific criteria: they were English-speaking individuals with chronic pelvic pain and/or unexplained infertility, owned smartphones, and had no prior diagnosis of endometriosis. The results demonstrated that the EndoRA score exhibited a high sensitivity of 93.1% but a low specificity of 5.9% in detecting endometriosis. The positive predictive value was 94.1%, while the negative predictive value was 5.0%. Although the study had limitations and potential selection bias, its findings suggest that EndoRA can serve as a valuable screening tool for high-risk individuals, enabling them to identify themselves as being at an increased risk for endometriosis. EndoRA’s non-invasive nature, free access, and easy accessibility have the potential to streamline evaluation and treatment processes, thereby empowering individuals to seek timely care and ultimately improving patient outcomes and overall well-being.
Digital Alternative Communication for Individuals with Amyotrophic Lateral Sclerosis: What We Have
Authors: Fernandes Felipe , Barbalho Ingridy , Bispo Júnior Arnaldo , Alves Luca , Nagem Danilo , Lins Hertz , Arrais Júnior Ernano , Coutinho Karilany D. , Morais Antônio H. F. , Santos João Paulo Q. , Machado Guilherme Medeiros , Henriques Jorge , Teixeira César , Dourado Júnior Mário E. T. , Lindquist Ana R. R. , Valentim Ricardo A. M.
Published: August 2023

Amyotrophic Lateral Sclerosis is a disease that compromises the motor system and the functional abilities of the person in an irreversible way, causing the progressive loss of the ability to communicate. Tools based on Augmentative and Alternative Communication are essential for promoting autonomy and improving communication, life quality, and survival. This Systematic Literature Review aimed to provide evidence on eye-image-based Human–Computer Interaction approaches for the Augmentative and Alternative Communication of people with Amyotrophic Lateral Sclerosis. The Systematic Literature Review was conducted and guided following a protocol consisting of search questions, inclusion and exclusion criteria, and quality assessment, to select primary studies published between 2010 and 2021 in six repositories: Science Direct, Web of Science, Springer, IEEE Xplore, ACM Digital Library, and PubMed. After the screening, 25 primary studies were evaluated. These studies showcased four low-cost, non-invasive Human–Computer Interaction strategies employed for Augmentative and Alternative Communication in people with Amyotrophic Lateral Sclerosis. The strategies included Eye-Gaze, which featured in 36% of the studies; Eye-Blink and Eye-Tracking, each accounting for 28% of the approaches; and the Hybrid strategy, employed in 8% of the studies. For these approaches, several computational techniques were identified. For a better understanding, a workflow containing the development phases and the respective methods used by each strategy was generated. The results indicate the possibility and feasibility of developing Human–Computer Interaction resources based on eye images for Augmentative and Alternative Communication in a control group. The absence of experimental testing in people with Amyotrophic Lateral Sclerosis reiterates the challenges related to the scalability, efficiency, and usability of these technologies for people with the disease. Although challenges still exist, the findings represent important advances in the fields of health sciences and technology, promoting a promising future with possibilities for better life quality.
A History of Innovation: Tracing the Evolution of Imaging Modalities for the Preoperative Planning of Microsurgical Breast Reconstruction
Authors: Cevik Jevan , Seth Ishith , Hunter-Smith David J. , Rozen Warren M.
Published: August 2023

Breast reconstruction is an essential component in the multidisciplinary management of breast cancer patients. Over the years, preoperative planning has played a pivotal role in assisting surgeons in planning operative decisions prior to the day of surgery. The evolution of preoperative planning can be traced back to the introduction of modalities such as ultrasound and colour duplex ultrasonography, enabling surgeons to evaluate the donor site’s vasculature and thereby plan operations more accurately. However, the limitations of these techniques paved the way for the implementation of modern three-dimensional imaging technologies. With the advancements in 3D imaging, including computed tomography and magnetic resonance imaging, surgeons gained the ability to obtain detailed anatomical information. Moreover, numerous adjuncts have been developed to aid in the planning process. The integration of 3D-printing technologies has made significant contributions, enabling surgeons to create complex haptic models of the underlying anatomy. Direct infrared thermography provides a non-invasive, visual assessment of abdominal wall vascular physiology. Additionally, augmented reality technologies are poised to reshape surgical planning by providing an immersive and interactive environment for surgeons to visualize and manipulate 3D reconstructions. Still, the future of preoperative planning in breast reconstruction holds immense promise. Most recently, artificial intelligence algorithms, utilising machine learning and deep learning techniques, have the potential to automate and enhance preoperative planning processes. This review provides a comprehensive assessment of the history of innovation in preoperative planning for breast reconstruction, while also outlining key future directions, and the impact of artificial intelligence in this field.
Quantitative Assessment of Hyperpigmentation Changes in Human Skin after Microneedle Mesotherapy Using the Gray-Level Co-Occurrence Matrix (GLCM) Method
Authors: Wawrzyk-Bochenek Iga , Rahnama Mansur , Wilczyński Sławomir , Wawrzyk Anna
Published: August 2023

Aim: The aim of the study was to quantitatively assess the effectiveness of microneedle mesotherapy in reducing skin discoloration. The results were analyzed using the gray-level co-occurrence matrix (GLCM) method. Material and methods: The skin of the forearm (7 × 7 cm) of 12 women aged 29 to 68 was examined. Microneedle mesotherapy was performed using a dermapen with a preparation containing 12% ascorbic acid. Each of the volunteers underwent a series of four microneedle mesotherapy treatments. The effectiveness of the treatment was quantified using the methods of image analysis and processing. A series of clinical images were taken in cross-polarized light before and after a series of cosmetic procedures. Then, the treated areas were analyzed by determining the parameters of the gray-level co-occurrence matrix (GLCM) algorithm: contrast and homogeneity. Results: During image pre-processing, the volunteers’ clinical images were separated into red (R), green (G) and blue (B) channels. The photos taken after the procedure show an increase in skin brightness compared to the photos taken before the procedure. The average increase in skin brightness after the treatment was 10.6%, the average decrease in GLCM contrast was 10.7%, and the average homogeneity increased by 14.5%. Based on the analysis, the greatest differences in the GLCM contrast were observed during tests performed in the B channel of the RGB scale. With a decrease in GLCM contrast, an increase in postoperative homogeneity of 0.1 was noted, which is 14.5%.
Dinutuximab Beta Maintenance Therapy in Patients with High-Risk Neuroblastoma in First-Line and Refractory/Relapsed Settings—Real-World Data
Authors: Wieczorek Aleksandra , Żebrowska Urszula , Ussowicz Marek , Sokół Agnieszka , Stypińska Marzena , Dembowska-Bagińska Bożenna , Pawińska-Wąsikowska Katarzyna , Balwierz Walentyna
Published: August 2023

Dinutuximab beta is approved for the maintenance treatment of patients with high-risk neuroblastoma (HR-NB), including patients with relapsed/refractory (R/R) disease. However, the data on its use in real-world clinical practice is limited. We retrospectively reviewed the clinical records of 54 patients with HR-NB who received maintenance therapy with dinutuximab beta in first-line (37 patients) or R/R settings (17 patients) at three centers in Poland. Of the 37 patients who received first-line treatment, twenty-eight had a complete response, two had a partial response, three had progressive disease, and four relapsed at the end of treatment. The median overall survival (OS) was 24.37 months, and the three-year progression-free survival (PFS) and OS were 0.63 and 0.80, respectively. Of the 17 patients in the R/R group, 11 had a complete response, two had a partial response, one had stable disease, and three had progressive disease or relapsed at the end of treatment. The median OS was 33.1 months and the three-year PFS and OS were 0.75 and 0.86, respectively. Treatment was generally well tolerated, including in patients with co-morbidities and those who had experienced toxicities with previous therapies. These findings demonstrate that the use of dinutuximab beta is feasible and beneficial as a first-line or R/R treatment in routine clinical practice in Poland.
Can 16 Minutes of HIIT Improve Attentional Resources in Young Students?
Authors: Andrade-Lara Karina E. , Latorre Román Pedro Ángel , Párraga Montilla Juan Antonio , Cabrera Linares José Carlos
Published: August 2023

Attentional resources are a cornerstone of both cognitive and academic performance. The purpose of this study was to analyse the effect of high-intensity interval training (HIIT) sessions on selective attention and visuoperceptual ability in young students. A total of 134 students (12.83 ± 1.23 years) joined this study. They were randomly assigned to a control group (CG) (n = 67), which watched a documentary, or an experimental group (EG) (n = 67), which performed 16 min of HIIT. Attention and visuoperceptual ability were assessed through the Perception of Similarities and Differences test (Caras-R test). A repeated-measures two-way ANOVA analysis was conducted. The CG showed an increased number of errors compared to the EG (p < 0.001) and showed a lower Impulsivity Control Index (p < 0.001) after the investigation. The EG, meanwhile, showed an increased number of hits (p < 0.001), Impulsivity Control Index (p < 0.001), and attentional efficacy (p < 0.001). In addition, the EG showed a decreased number of errors (p < 0.001) and omissions (p < 0.01). In conclusion, 16 min of HIIT was time-effective in improving selective attention and visuoperceptual ability in young students. These results show the importance of physical exercise and the promotion of physical activity breaks during the academic day to improve learning processes.
Risk Factors for Pneumocystis jirovecii Pneumonia in Non-HIV Patients Hospitalized for COVID-19: A Case-Control Study
Authors: Viceconte Giulio , Buonomo Antonio Riccardo , D’Agostino Alessia , Foggia Maria , Di Fusco Antonio , Pinchera Biagio , Scotto Riccardo , Iacovazzo Carmine , Fanasca Luca , Messina Gaetana , Cacciatore Francesco , Salvatore Paola , Gentile Ivan ,   on behalf of the Federico II COVID Team
Published: August 2023

Background: Very few cases of Pneumocystis jirovecii pneumonia (PJP) have been reported in COVID-19 so far, and mostly in patients with concomitant HIV infection or in solid-organ transplant recipients. Despite COVID-19 being associated with lymphopenia and the use of steroids, there are no studies specifically aimed at investigating the risk factors for PJP in COVID-19. Methods: A retrospective case-control study was performed. We matched PJP cases with controls with a 1:2 ratio, based on age ± 10 years, solid-organ transplantation (SOT), hematological malignancies, and in the setting of PJP development (ICU vs. non-ICU). A direct immunofluorescence assay on bronchoalveolar lavage fluid was used to diagnose PJP. Results: We enrolled 54 patients. Among 18 cases of PJP, 16 were diagnosed as “proven”. Seven of the eighteen cases were immunocompromised, while the other patients had no previous immunological impairment. Patients with PJP had significantly lower median lymphocyte values (p = 0.033), longer COVID-19 duration (p = 0.014), a higher dose of steroid received (p = 0.026), higher CRP values (p = 0.005), and a lower SARS-CoV-2 vaccination rate than the controls (p = 0.029). Cumulative steroid dose is the independent risk factor for PJP development (OR = 1.004, 95%CI = 1–1.008, p = 0.042). Conclusions: PJP develops in COVID-19 patients regardless of immunosuppressive conditions and the severity of disease, and it is correlated to the corticosteroid dose received.
First Reported Case of a Clinically Nonresponsive-to-Itraconazole Alternaria alternata Isolated from a Skin Infection of a Nonimmunocompromised Patient from Romania
Authors: Colosi Ioana Alina , Crișan Maria , Țoc Dan Alexandru , Colosi Horațiu Alexandru , Georgiu Carmen , Sabou Marcela , Costache Carmen
Published: August 2023

Background: Alternaria alternata is a melanic fungus capable of causing a wide variety of infections, some of which have lethal potential. It is a ubiquitous fungus and a well-known plant pathogen. Cutaneous infections with Alternaria alternata most often occur in the extremities of patients who perform conventional agriculture, thus being exposed to occupational hazards leading to the disruption of the skin barrier. Methods: This paper presents the first case report from Romania of an itraconazole nonresponsive cutaneous alternariosis in a patient without any type of immunosuppression. Results: After an initial misdiagnosis regarding the etiology of the patient’s skin infection, two successive punch biopsies, followed by mycologic examination, lead to the final diagnosis of cutaneous alternariosis. Treatment guided by antifungal susceptibility testing has been instituted, leading to the gradual healing of the patient’s skin ulcerations. Conclusions: The ability of Alternaria alternata to infect immunocompetent human hosts and to develop resistance to antifungal drugs highlight the importance of correctly diagnosing the etiology of skin ulcerations and instituting appropriate treatment guided by antifungal susceptibility testing whenever the suspicion of a fungal skin infection is plausible.
Research on the Spatial-Temporal Variation of Resources and Environmental Carrying Capacity and the Impact of Supply-Side Reform on Them: Evidence from Provincial-Level Data in China
Authors: Xu Mingjun , Chen Changling , Lin Shugao , Shen Duanshuai
Published: August 2023

Both the resource environmental carrying capacity (RECC) and supply-side reform are crucial for achieving sustainable national developments. However, current research on RECC lacks consideration of the supply-side industrial structures and factors, and the relationship between RECC and supply-side reform remains unrevealed. In order to measure the RECC in China at the provincial level from 2005 to 2019, this study constructs an evaluation index based on industrial structure. It utilizes the TOPSIS model coupled with the supply-demand balance method and environmental capacity method while gathering and summarizing the indicators related to natural resource support, socio-economic support, and environmental factor accommodation. The analysis of evolutionary characteristics and spatial heterogeneity is carried out by statistical and spatial econometric methods, and the impact of the supply-side reform policy on RECC is examined using a bidirectional fixed-effect model. The findings indicate the following: (1) China’s RECC demonstrates a clear upward trend, with higher values in the west and lower values in the east. The average annual growth rate from 2016 to 2019 (18.12%) is nearly three times that of the period from 2005 to 2010 (6.28%), indicating a significant acceleration in the increase in RECC post-supply-side reform. (2) The spatial agglomeration of RECC and its sub-system support is observed, as the allocation of nature resources and markets promotes the convergence of regional differences and enhances the spatial convergence of the RECC. (3) The implementation of supply-side reform policies has a positive impact on RECC, with industrial upgrading playing a particularly significant role. This study provides a new idea and method for the selection of evaluation indicators, quantitatively assessing province-level RECC and understanding the potential effects of national supply-side policies on RECC.
The Effect of Multi-Session Prefrontal Cortical Stimulation on Aggression: A Randomized, Double-Blind, Parallel-Group Trial
Authors: Choy Olivia , Tan Gary , Wong Yen Cong
Published: August 2023

Findings from brain imaging studies investigating the neural underpinnings of antisocial behavior have implicated the prefrontal cortex in the regulation of aggressive reactions. However, relatively few studies have examined the role of the prefrontal cortex on aggression in an experimental way. This study examines whether upregulating the prefrontal cortex using repeated transcranial direct current stimulation (tDCS) reduces aggressive behavior. In a double-blind, parallel-group, randomized controlled trial, 88 healthy adults (42 males, 46 females) were assigned to one session of anodal tDCS over the ventromedial prefrontal cortex (n = 47) or sham stimulation (n = 41) per day for three consecutive days and assessed using a behavioral measure of aggression. Levels of aggressive responses post-intervention did not significantly differ between the active and sham stimulation groups. However, a significant interaction effect between the stimulation group and gender was observed, whereby males, but not females, exhibited reduced aggression after prefrontal stimulation. To the authors’ knowledge, this is the first study to examine the effect of multi-session prefrontal tDCS on aggressive behavior in healthy adults. Results highlight that there are differences in responsivity to tDCS in modifying aggressive behavior.
Novel Pharmacological Targets of Post-Traumatic Stress Disorders
Authors: Marazziti Donatella , Carmassi Claudia , Cappellato Gabriele , Chiarantini Ilaria , Massoni Leonardo , Mucci Federico , Arone Alessandro , Violi Miriam , Palermo Stefania , De Iorio Giovanni , Dell’Osso Liliana
Published: August 2023

Post-traumatic stress disorder (PTSD) is a psychopathological condition with a heterogeneous clinical picture that is complex and challenging to treat. Its multifaceted pathophysiology still remains an unresolved question and certainly contributes to this issue. The pharmacological treatment of PTSD is mainly empirical and centered on the serotonergic system. Since the therapeutic response to prescribed drugs targeting single symptoms is generally inconsistent, there is an urgent need for novel pathogenetic hypotheses, including different mediators and pathways. This paper was conceived as a narrative review with the aim of debating the current pharmacological treatment of PTSD and further highlighting prospective targets for future drugs. The authors accessed some of the main databases of scientific literature available and selected all the papers that fulfilled the purpose of the present work. The results showed that most of the current pharmacological treatments for PTSD are symptom-based and show only partial benefits; this largely reflects the limited knowledge of its neurobiology. Growing, albeit limited, data suggests that the hypothalamic-pituitary-adrenal axis, opioids, glutamate, cannabinoids, oxytocin, neuropeptide Y, and microRNA may play a role in the development of PTSD and could be targeted for novel treatments. Indeed, recent research indicates that examining different pathways might result in the development of novel and more efficient drugs.
Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes
Authors: Onea Horea-Laurentiu , Spinu Mihail , Homorodean Calin , Ober Mihai Claudiu , Olinic Maria , Lazar Florin-Leontin , Achim Alexandru , Tataru Dan Alexandru , Olinic Dan Mircea
Published: August 2023

This study investigates the clinical relevance and therapeutic implications of the OCT identification of intracoronary superficial calcified plates (SCPs) in acute coronary syndromes (ACSs). In 70 consecutive ACS patients (pts), we studied the three main underlying ACS mechanisms: plaque erosion (PE), plaque rupture and eruptive calcified nodule (CN). The PE lesions, occurring on an intact fibrous cap overlying a heterogeneous substrate, were identified in 12/70 pts (17.1%). PE on superficial calcified plates (PE-SCP) represented 58.3% of the PE lesions (7/12 pts) and had a 10% overall incidence in the culprit lesions (7/70 pts). PE-SCP lesions occurred mostly on the left anterior descending artery, correlated with white thrombi (85.7%) and had a proximal intraplaque site (71.4%). PE-SCP lesions were treated conservatively, as nonsignificant lesions, in 4/7 pts. Our study emphasizes that the coronary calcium-related ACS risk is not only associated with the spotty calcifications or CN but also with the PE-SCP lesions.
Ohmic Contact to n-GaN Using RT-Sputtered GaN:O
Authors: Maslyk Monika , Prystawko Pawel , Kaminska Eliana , Grzanka Ewa , Krysko Marcin
Published: August 2023

One of the key issues in GaN-based devices is the resistivity and technology of ohmic contacts to n-type GaN. This work presents, for the first time, effective intentional oxygen doping of sputtered GaN films to obtain highly conductive n+-GaN:O films. We have developed a novel and simple method to obtain these films. The method is based on the room temperature magnetron sputtering of a single crystal bulk GaN target doped with oxygen. The n+-GaN:O films exhibit a polycrystalline structure with a crack-free surface and a free electron concentration of 7.4 × 1018 cm3. Ohmic contact to GaN:Si with n+-GaN:O sub-contact layer achieves specific contact resistance of the order of 10−5 Ωcm2 after thermal treatment. The obtained results are very promising for the development of the technology of a whole new class of ohmic contacts to n-GaN.
Screw Osteointegration—Increasing Biomechanical Resistance to Pull-Out Effect
Authors: Costăchescu Bogdan , Niculescu Adelina-Gabriela , Grumezescu Alexandru Mihai , Teleanu Daniel Mihai
Published: August 2023

Spinal disorders cover a broad spectrum of pathologies and are among the most prevalent medical conditions. The management of these health issues was noted to be increasingly based on surgical interventions. Spinal fixation devices are often employed to improve surgery outcomes, increasing spinal stability, restoring structural integrity, and ensuring functionality. However, most of the currently used fixation tools are fabricated from materials with very different mechanical properties to native bone that are prone to pull-out effects or fail over time, requiring revision procedures. Solutions to these problems presently exploited in practice include the optimal selection of screw shape and size, modification of insertion trajectory, and utilization of bone cement to reinforce fixation constructs. Nevertheless, none of these methods are without risks and limitations. An alternative option to increasing biomechanical resistance to the pull-out effect is to tackle bone regenerative capacity and focus on screw osteointegration properties. Osteointegration was reportedly enhanced through various optimization strategies, including use of novel materials, surface modification techniques (e.g., application of coatings and topological optimization), and utilization of composites that allow synergistic effects between constituents. In this context, this paper takes a comprehensive path, starting with a brief presentation of spinal fixation devices, moving further to observations on how the pull-out strength can be enhanced with existing methods, and further focusing on techniques for implant osteointegration improvement.
Saturation-Induced Variable-Flux Characteristics in a 12-Slot 10-Pole Concentrated Winding Permanent-Magnet Motor
Authors: Yokoi Yuichi , Higuchi Tsuyoshi
Published: August 2023

This paper proposes a stator core design to achieve variable-flux characteristics enhanced by magnetic saturation in fractional-slot concentrated winding (FSCW) permanent-magnet (PM) motors without additional excitation systems, complicated structures, or active controls. Magnetic saturation induced at suitable locations can enhance variable-flux characteristics because the PM flux linkage is variable with the magnetic saturation in cores. In distributed winding configurations, magnetic saturation is induced symmetrically for each rotor pole by the fundamental that is dominant in the spatial distribution of the air-gap flux density. The magnetic saturation at each rotor pole can enhance variable-flux characteristics. In FSCW configurations, magnetic saturation is not induced symmetrically for each rotor pole because of several dominant space harmonics. The magnetic saturation at several rotor poles cannot enhance variable-flux characteristics. In the proposed design, the stator core has thin tooth tips for inducing magnetic saturation. The magnetic saturation in the stator core achieves the variable-flux characteristics that are effective for expanding the operating region or decreasing electromotive force and increasing torque. The efficacy of the proposed design is determined by estimating motor performance through a finite element method analysis and demonstrating the actual motor performance of a prototype.
Modi-Red Mud Loaded CoCatalyst Activated Persulfate Degradation of Ofloxacin
Authors: Wu Qu , Sun Wenquan , Shah Kinjal J. , Sun Yongjun
Published: August 2023

As an abundant potentially dangerous waste, red mud (RM) requires a straightforward method of resource management. In this paper, an RM catalyst loaded with cobalt (Co-RM) was prepared by the coprecipitation method for the efficient activation of persulfate (PS). Its degradation performance and mechanism of ofloxacin (OFL) were investigated. The characterization results of scanning electron microscopy, X-ray diffractometer, and energy dispersive spectrometer showed cobalt was successfully loaded onto the surface of RM, and the catalyst produced could effectively activate PS. Under the conditions of 15 mg/L OFL, 0.4 g/L Co-RM, 4 g/L PDS, 3.0 pH, and 40 °C temperature, the maximum removal rate of OFL by the Co-RM/PDS system was 80.06%. Free radical scavenging experiments confirmed sulfate radicals were the main active substances in the reaction system. The intermediates in OFL degradation were further identified by gas chromatography-mass spectrometry, and a possible degradation pathway was proposed. Finally, the relationship between defluorination rate and time in the Co-RM/PDS degradation OFL system was described by the first-order kinetic equation. This work reports an economical, environmental solution to the use of waste RM and provides a research basis for the further exploration of RM-based catalysts.
Bayesian Joint Modeling Analysis of Longitudinal Proportional and Survival Data
Authors: Liu Wenting , Li Huiqiong , Tang Anmin , Cui Zixin
Published: August 2023

This paper focuses on a joint model to analyze longitudinal proportional and survival data. We utilize a logit transformation on the longitudinal proportional data and employ a partially linear mixed-effect model. With this model, we estimate the unknown function of time using the B-splines technique. Additionally, we introduce a centered Dirichlet process mixture model (CDPMM) to capture the random effects, allowing for a flexible distribution. The survival data are assumed using a Cox proportional hazard model, and the sharing random effects joint model is developed for the two types of data. We develop a Bayesian Lasso (BLasso) approach that combines the Gibbs sampler and the Metropolis–Hastings algorithm. The proposed method allows for the estimation of unknown parameters and the selection of significant covariates simultaneously. We evaluate the performance of our proposed methods through simulation studies and also provide an illustration of our methodologies using an example from the MA.5 research experiment.
A New Definition of the Dual Interpolation Curve for CAD Modeling and Geometry Defeaturing
Authors: Chi Baotao , Bai Shengmin , Guo Qianjian , Zhang Yaoming , Yuan Wei , Li Can
Published: August 2023

The present paper provides a new definition of the dual interpolation curve in a geometric-intuitive way based on adaptive curve refinement techniques. The dual interpolation curve is an implementation of the interpolatory subdivision scheme for curve modeling, which comprises polynomial segments of different degrees. Dual interpolation curves maintain various desirable properties of conventional curve modeling methods, such as local adaptive subdivision, high interpolation accuracy and convergence, and continuous and discontinuous boundary representation. In addition, the dual interpolation curve is mainly applied to solve the difficult geometry defeaturing problems for curve modeling in existing computer-aided technology. By adding fictitious and intrinsic nodes inside or at the vertices of interpolation elements, the dual interpolation curve is flexible and convenient for characterizing a set of ordered points or discrete segments. Combined with the Lagrange interpolation polynomial and meshless method, the proposed approach is capable of characterizing the non-smooth boundary for geometry defeaturing. Experimental results are given to verify the validity, robustness, and accuracy of the proposed method.
Correction: Islam et al. Generalized Moment Method for Smoluchowski Coagulation Equation and Mass Conservation Property. Mathematics 2023, 11, 2770
Authors: Islam Md. Sahidul , Kimura Masato , Miyata Hisanori
Published: August 2023

There were some errors in the original publication [...]