bluuebunny/crossref_metadata_2025 huggingface dataset:
The Illusory Promise of Economic Nexus
Authors: Thimmesch Adam B.
Published: May 2022

The economic nexus standard has gained significant support during the last decade as the proper standard for determining the scope of states’ taxing powers under the Dormant Commerce Clause. Unfortunately, however, despite the widespread acceptance of that standard in the abstract, there is no uniform understanding of what economic nexus actually means. State courts that have adopted that standard have generally failed to explain its parameters, and those few courts that have actually addressed the scope of economic nexus have adopted artificially high standards that severely restrict its reach. Actions by state legislatures and revenue authorities have been much the same. Uncertainty reigns, yet those disparate approaches to the same constitutional standard have yet to receive scholarly attention. This Article seeks to fill that void by analyzing state actions in this area and by evaluating how states’ different formulations for economic nexus will likely develop over time. Such an analysis shows that states’ economic nexus formulations have little theoretical or jurisprudential grounding and will necessarily change and deteriorate over time. As a result, states’ actions in this area will be non-uniform and will maintain the significant uncertainty that currently exists. Federal attention to economic nexus is thus warranted to prevent state actions from undermining the goals of the Dormant Commerce Clause. This Article analyzes several potential federal responses and concludes that Congress should intervene and adopt a federal factor nexus standard based on the Multistate Tax Commission’s model formulation.
GEOMETRIA SAGRADA E ARABESCOS ISLÂMICOS
Authors: Prates Luciana Cangussu
Published: May 2022

As construções religiosas no Islã ligam os padrões regulares a um sentido mais espiritual. Suas produções artísticas se apresentam socioculturalmente como notáveis registros a evidenciarem o forte elo existente entre o sagrado e as formas geométricas. Nesse sentido, a arte islâmica sustenta, na vida tangível, a subjetividade da crença em Alláh. Neste momento, citam-se os arabescos como ilustração principal dessa realidade. No mundo muçulmano, a predominância da noção da impermanência do ser humano, unida à experiência do infinito, projeta-se sobre a arte dos arabescos, tornando visível seu vínculo com o transcendente. Segundo a tradição, os arabescos se constituem por meio da repetição regular de um padrão abstrato, semi-abstrato ou parcialmente figurativo, cuja simbologia explicita, por meio das formas geométricas, a profunda fé na eternidade de todo ser. Por essa razão, a presente comunicação visa traçar um breve paralelo entre os conhecimentos da geometria sagrada e os estudos ligados aos arabescos islâmicos.
Datenschutz und Data Science
Authors: Meinecke Dominik
Published: May 2022

Artificial Intelligence, Machine Learning and Big Data pose a challenge to the European data protection law. Due to the technology-neutral design of the General Data Protection Regulation, the requirements for these kinds of applications are unclear. The author therefore examines the compatibility of data science with data protection law using the example of employee data protection. Additionally, a possible legislative need for action on European level is explored as well as the extent to which the member states still have room for maneuver, at least in the area of employee data protection.
How Do Iranian Stakeholders Think About Pharmaceutical Managed Entry Agreements?
Authors: Shobeiri Nikta , Peiravian Farzad , Yousefi Nazila
Published: May 2022

Background: Uncertainty in real-world product profiles is the main barrier to pharmaceutical market access. Managed entry agreements (MEAs) are the formal arrangements to overcome these uncertainties. Despite the extensive experience of developed countries in implementing such agreements, the experience of developing countries is minimal. As health decision-makers in Iran have moved towards implementing MEAs since 2020, seeking stakeholders' insights is crucial for filling this experience gap and facilitating the optimal implementation of these new policies. Methods: Our research was done in three phases: (1) Focus group interviews to disclose the main objectives of implementing MEAs in Iran, (2) the AHP approach to prioritize uncertainties, and (3) individual semi-structured interviews to carry out strengths, weaknesses, opportunities, and threats (SWOT) analysis. Results: Based on our stakeholders' views, increasing flexibility in improving patients' access to innovative and expensive drugs and responding to budget impact uncertainty seems highly prioritized for conducting MEAs in Iran. The SWOT analysis showed that although MEAs have the chance for success due to their strengths and opportunities, such as providing early and assured access, allocating resources efficiently, and enhancing the efficiency of post-marketing studies, policymakers should consider the weaknesses and threats such as difficulty in defining outcomes, high transaction cost, and lack of suitable infrastructure to increase the success rate. Conclusions: Efficient implementation of MEAs depends on the weaknesses and threats and considering the views of relevant stakeholders. Constructive interaction among all stakeholders is essential for adequately executing MEAs.
Development and Application of Dtxr and Tox Genes Targeting Real-time PCR to Identify Corynebacterium diphtheriae, C. ulcerans, and C. pseudotuberculosis Simultaneously
Authors: Sunarno Sunarno , Hartoyo Yudi , Amalia Novi , Sofiah Sundari Nur , Rizki Aulia , Puspandari Nelly , Febriyana Dwi , Febrianti Tati , Saraswati Ratih Dian , Muna Fauzul , Novita Risqa , Lienggonegoro Lisa Andriani , Ernawati Fitrah
Published: May 2022

Background: Corynebacterium diphtheriae, C. ulcerans, and C. pseudotuberculosis are known as diphtheria-causing bacteria. Although diphtheria therapy is administered based on the clinical manifestations, some cases are mild and atypical. The immediate and accurate identification of diphtheria-causing bacteria is of paramount importance to prevent the spread of the disease and provide case management as early as possible. Unfortunately, conventional methods as the gold standard are time-consuming. Objectives: This study aimed to develop and implement a multiplex real-time PCR with the dtxR and tox genes as the target to identify three species of diphtheria-causing bacteria and screen their toxigenicity quickly and accurately. Methods: The research sample encompassed seven reference strains, one synthetic DNA, 30 archived isolates, and 924 clinical specimens isolated from 311 diphtheria cases and 613 close contacts. The conventional methods as the gold standard and the established PCR assay were used to verify the results of multiplex real-time PCR developed in this study. Results: The multiplex real-time PCR could identify seven reference strains, one synthetic DNA, and 30 archived isolates as accurately as the conventional methods and the established PCR. Similar to established PCR, the multiplex real-time PCR identified diphtheria-causing bacteria in 120 (38.6%) out of 311 and 12 (2%) out of 613 clinical specimens from diphtheria cases and close contacts, respectively. Meanwhile, the conventional methods identified diphtheria-causing bacteria in 79 (25.4%) out of 311 and three (0.5%) out of 613 clinical specimens. Conclusions: The multiplex real-time PCR developed in this study can be used to identify three species of diphtheria-causing bacteria and screen their toxigenicity quickly and accurately. However, in this study, no diphtheria-causing bacteria other than C. diphtheriae was found in the clinical samples using the PCR or conventional methods. PCR is more sensitive than the conventional methods and can be used as an additional test in diphtheria laboratories.
The Nail Bed: Theories of Its Functioning and Therapeutic Mechanisms of Dermabrasion
Authors: Avila-alvarez Alejandra Maria , Gomez-Vargas Luz Marina , Velez-Pelaez Maria Camila
Published: May 2022

Introduction: The nail bed is a fundamental structure of the nail unit given its close relationship with the nail plate, the distal matrix, and the hyponychium. How it interacts with these structures is still a matter of study. Case Presentation: We describe clinical cases of patients with traumatic destruction of the nail bed treated with mechanical dermabrasion in a reference center. Both clinical cases had a satisfactory response to the treatment, which supports the proposed theories about the functioning of the nail bed. Conclusions: The nail bed is a dynamic tissue that closely interacts with adjacent structures and responds to forces applied to it.
Objective Representation and Non-Physical Entities
Authors: Mazarian Alireza ,   Philosophy Documentation Center
Published: May 2022

What can we learn about the existence of non-physical entities (or a particular non-physical entity) from close inquiry into special kinds of experiences? Contemporary analytic philosophy has sometimes studied mystic experiences as evidence for the existence of such entities (for example, see: Broad 1939; Swinburne 2004; Plantinga 1981; Alston 1991). The article is organized as follows: first, I discuss several distinctions that seem to me to play substantive roles in philosophizing about such experiences. I will then offer and criticize two arguments that support the significance of the experiences. The arguments do not show whether a non-physical entity does or does not exist; they highlight a philosophical (and not theological) framework that can be beneficial to a variety of different approaches. Based on a heuristic strategy, the arguments will focus on the possibility/impossibility of objective representation of non-physical entities. They invite the reader (opponent, proponent, or neutral) to reflect on deeper philosophical grounds necessary for evaluating any positive or negative claims about the significance/insignificance of such experiences. The first argument rests on contemporary theories and assumptions. The second argument will use notions that drive from Classic Arabic-Persian Philosophy.
Social Justice and Liturgical Practice
Authors: Bradley Daniel O’Dea ,   Philosophy Documentation Center
Published: May 2022

In North America, across the political spectrum, we have a strong tendency to reduce religion to nothing more than a tool to promote our own socio-political views. This is a natural consequence of our hyper-polarized culture and our impoverished view of “religion.” It is also, however, a problem—particularly for those inspired by the call to renewal through an integration of the quest for social justice and the pursuit of the spiritual life. By focusing on the value of participating in religious liturgy, I show how a renewed respect for religion can help the proponents of social justice fulfil some of the foundational desires of the original movement and, thereby, to bring to fruition some of its dormant promise. This includes, in particular, the desire for social harmony and the desire to pay greater attention to our concrete reality.
Unveiling an enigma from the Cerrado: taxonomic revision of two sympatric species of Apostolepis Cope, 1862 (Dipsadidae: Xenodontinae: Elapomorphini) from central Brazil
Authors: Entiauspe-Neto Omar M. , Koch Claudia , Guedes Thaís B. , Paredero Rafael C.B. , Tiutenko Arthur , Loebmann Daniel
Published: May 2022

Apostolepis albicollaris and A. cerradoensis are two Elapomorphini snake species, described within a short timespan, from the Cerrado of central Brazil. In their brief descriptions, these two species were diagnosed from congeners largely based on highly variable external morphological characters. Interestingly enough, A. cerradoensis has remained known based on a single specimen since its description. Here, we present a reanalysis of both type specimens, as well as a careful examination of a large series of specimens formerly assigned to these species, based on the comparison of internal and external morphology. We conclude that both species are synonymous, providing evidence for the recognition of A. cerradoensis as a junior synonym of A. albicollaris. Furthermore, an account of its updated diagnosis, morphological variation, geographic distribution, hemipenial morphology, phylogenetic relationships and an osteological description are also provided. We also discuss its conservation status, suggesting that the species is under threat and qualifies to be listed as Vulnerable (VU ab(iii)), considering its rarity, small geographic range, and persistent environmental threats.
Crumbling Rocks – Mindfulness Techniques for Awareness, Understanding and Ownership of Toxic Masculinity within Improvisation-Based Movement Training
Authors: Cornforth Charlie
Published: May 2022

Crumbling rocks is an analogy for my process of encountering my toxic masculinity within a movement improvisation setting. Whilst engaging in a flying low and passing through class facilitated at Plymouth Conservatoire, I began to observe how traits of my toxic masculinity were cultivating interruptions to the flow of a given improvisation. After several other encounters, I began to realize that the improvisation setting has become a useful device for discovering and unpicking traits of toxic masculinity. By utilising mindfulness practices to observe key traits associated with hegemonic masculinity, the improvisation setting holds the potential to become an effective tool for uncovering, addressing, critiquing and undoing elements of toxic masculinity.
Autorregulación y autoconfianza para el afrontamiento de situaciones de riesgo al consumo en adictos a cocaína con trastornos de la personalidad
Authors: Martínez González José Miguel , Verdejo García Antonio , Vilar López Raquel
Published: May 2022

Self-regulation and self-confidence to cope with use risk situations in cocaine addictswith personality disorders
Abstract: The objective of this study was to get to know the capacity for self-regulation, the level of self-confidence to resist use and their relationship with the presence of personality disorders, abstinence and use-related beliefs . The sample consisted of 74 patients with cocaine addiction in outpatient treatment, with a mean age of 33 years, of which 94.6% were men, and 64.9% were patients with dual pathology at the start of treatment. Results showed that the planning phase of the self-regulation process is related to the level of self-confidence to resist use, the time of abstinence or the use-related beliefs. Patients with a personality disorder differ from the rest only in the motivation phase. There is a greater vulnerability regarding the planning phase, an aspect that should be taken into account throughout the treatment.
Keywords: self-regulation; self-confidence; risk; cocaine; treatment.
Resumen: El objetivo de este estudio fue conocer la capacidad de autorregulación, el nivel de autoconfianza para resistirse al consumo y la relación que puede tener con ellas la presencia de trastornos de la personalidad, la abstinencia y las creencias relacionadas con el consumo. La muestra estaba compuesta por 74 pacientes adictos a cocaína en tratamiento ambulatorio, con una edad media de 33 años, un 94.6% de hombres y un 64.9% de pacientes con patología dual al iniciar el tratamiento. Los resultados mostraron que la fase de planificación del proceso de autorregulación se relaciona con el nivel de autoconfianza para resistirse al consumo, el tiempo de abstinencia o las creencias relacionadas con el consumo. Los pacientes con trastorno de la personalidad se diferencian del resto solo en la fase de motivación. Se constata una mayor vulnerabilidad en relación con la fase de planificación, aspecto que debe tenerse en cuenta a lo largo del tratamiento.
Palabras clave: autorregulación; autoconfianza; riesgo; cocaína; tratamiento.
A faunistic review of Spondylidinae Audinet-Serville, 1832 (Coleoptera: Cerambycidae) of the south-eastern Baltic region (Lithuania and the Kaliningrad Region)
Authors: Tamutis Vytautas , Alekseev Vitalii
Published: May 2022

The paper presents, for the first time, a review of species composition and distribution of the Spondylidinae Audinet-Serville, 1832 subfamily (Coleoptera: Cerambycidae) in the south-eastern Baltic region. A total of more than 600 records were analyzed and more than 800 specimens were examined. In this region, the subfamily is confirmed to be represented by four tribes, five genera, and seven species. Previous records (published notifications) of Nothorhina punctata (F.) were not confirmed in the region. The information on the ocurrence, natural history, and zoogeography for nine species found and expected to be found in the region is presented in the paper. Local distribution of six species is mapped.
Recent doctoral theses (biochemistry, biology, biophysics, ecology and environmental) in Lithuania
Authors: Lipatova Indrė
Published: May 2022

The research objective of this work was to investigate and study details of the CRISPR adaptation process in several different CRISPR-Cas systems as well as use genome-wide CRISPR screening to elucidate cell-intermedilysin interactions. The results of this study showed that Cas1-Cas2 complex from S. thermophilus CRISPR4-Cas system forms a complex that integrates prespacers into the CRISPR array. DnaQ domain fused to Cas2 in this system is a 3’–5’ DNA exonuclease. DnaQ domain is dispensable for spacer integration; however, it serves to trim back overextended 3’ overhangs of the prespacer. Cas1, Cas2, and Csn2 proteins from S. thermophilus CRISPR3-Cas system form at least three different complexes, which interact with Cas9 from the same system via the DNA tether. The identified complexes from CRISPR3-Cas system represent a spacer capture step of the new spacer acquisition process, as they harbour spacer length DNA in their assemblies. Genome-wide CRISPR screening can reveal novel fundamental biological pathways in the membrane composition and lipid metabolism when used in concert with membrane targeting toxins. Intermedilysin has many more dependency factors than previously known CD59 and cholesterol. Among them are heparan sulfates, glucosylceramides, and many other protein or lipid glycosylation factors. ILY can be inhibited by heparin or the removal of heparan sulfates from cells using bacterial heparinases.
Synthesis of pyrimidines containing hydroxamic acid, 1,3,4-oxadiazole or 1,2,4-triazole moieties as potential HDAC inhibitors
Authors: Jakubkienė Virginija , Žvirblis Mantas , Tumkevičius Sigitas
Published: May 2022

The histone deacetylases (HDACs) play an essential role in the transcriptional regulation of cells through deacetylation of nuclear histone proteins and are promising therapeutic targets for treatment of various diseases. Therefore, interest to the design and synthesis of novel HDAC inhibitors, among which hydroxamic acids occupy an important place, has been constantly increasing in recent years. Here, synthesis of pyrimidines with 1,3,4-oxadiazole or 1,2,4-triazole and hydroxamic acid moieties as potential HDAC inhibitors is described. The target compounds were obtained by sequential reactions of (O- and N-pyrimidinyl)alkanoates with hydrazine hydrate followed by cyclization reaction of the obtained hydrazides with potassium O-ethyl xanthate and alkylation of the synthesised oxadiazole(triazole)thiones with 2-chloro-N-hydroxyacetamide. One of 1,3,4-oxadiazole-2-thiones under the treatment with hydrazine hydrate underwent the recyclisation reaction to give the corresponding 4-amino-1,2,4-triazole. Investigation of the inhibitory activity of the synthesised compounds against HDAC4 and HDAC8 isoforms revealed that N-hydroxy-2-(5-(4-(6-(6-methyl-2-(methylthio)pyrimidin-4-yloxy) butyl)-1,3,4-oxadiazol-2-ylthio)acetamide exhibited a weak inhibitory activity against HDAC8 isoform (IC50 = 12.7 μM).
Cardio-Oncology Considerations in Oncologic Treatment Decisions
Authors: Fadol, PhD, FNP-BC, FAANP, FAAN Anecita
Published: May 2022

At JADPRO Live Virtual 2021, presenter Anecita P. Fadol, PhD, FNP-BC, FAANP, FAAN, emphasized the critical role advanced practitioners play in the identification, monitoring, and management of the cardiac complications of cancer therapy. Dr. Fadol’s presentation discussed identification of the most common cardiotoxicities associated with cancer therapy, clinical considerations related to common oncologic treatments with potential cardiotoxicity that may impact cancer treatment decisions, and the management of common cardiovascular issues in patients with cancer.
Positive Practice Changes After the COVID-19 Pandemic: From the Advanced Practice Provider Perspective
Authors: Harvey, PharmD, BCOP, FCCP, FHOPA R. Donald , Beuge, MS, RN, NP-C Aaron , Raine, PA-C Caleb , Yabroff, PhD, MBA Robin
Published: May 2022

At the opening session of JADPRO Live Virtual 2021, panelists shared creative responses to the COVID-19 pandemic and considered strategies to effectively respond to crises that may impact cancer patients and practices in the future.
Immunotherapy for the Treatment of Triple-Negative Breast Cancer
Authors: M. Tolaney, MD, MPH Sara , Shaw, ANP-BC, AOCNP Lindsay
Published: May 2022

At JADPRO Live Virtual 2021, Sara M. Tolaney, MD, MPH, and Lindsay Shaw, ANP-BC, AOCNP®, presented on recent clinical trial data for approved immune checkpoint inhibitors and antibody-drug conjugates, and their implications in the current treatment landscape, for metastatic triple-negative breast cancer. Dr. Tolaney and Ms. Shaw also discussed principles of monitoring and managing adverse events associated with immunotherapies.
Lung Cancer Biomarker Speak: Teach Me the Language
Authors: Sandy, MSN, CRNP Beth , Morrissette, PhD, FACMG Jennifer
Published: May 2022

A vital role of the advanced practitioner is to analyze biomarker testing reports and explain to patients how the results may impact their treatment. At JADPRO Live Virtual 2021, presenters reviewed the importance of molecular testing in non–small cell lung cancer and how to interpret molecular pathology reports.
Molecular Testing in Hematologic Malignancies
Authors: J. Zitella, MS, RN, ACNP-BC, AOCN Laura
Published: May 2022

Molecular testing technologies have been increasingly integrated into clinical research and are essential tools in the care of patients with hematologic malignancies. During this session at JADPRO Live Virtual 2021, Laura J. Zitella, MS, RN, ACNP-BC, AOCN®, reviewed key concepts for diagnostic testing with a focus on molecular testing (including cytogenetics, FISH, PCR, and next-generation sequencing) and discussed how to interpret the results for hematologic malignancies to inform prognosis as well as treatment.
Pull Up a Seat: Engaging Patients as Empowered Partners in Health Equity Transformation
Authors: Karmo Maimah , Pierre, MSN, ANP-BC Amy
Published: May 2022

At the JADPRO Live Virtual 2021 keynote interview, Maimah Karmo, CEO and Founder of the Tigerlily Foundation, spoke with Amy Pierre, MSN, ANP-BC, on her breast cancer experience and drive to establish an organization that educates, advocates for, and empowers young women of color at every stage of their breast cancer journey. Ms. Karmo and Ms. Pierre also discussed the role of the advanced practitioner in furthering patient-centered, equitable care.
Role of the Advanced Practitioner in the Management of Oral Chemotherapy for Adults With AML
Authors: Leak Bryant, PhD, RN, OCN, FAAN Ashley , Buhlinger, PharmD, BCOP, CPP Kaitlyn
Published: May 2022

Recent advances have resulted in an expansion of treatment options for AML, especially targeted therapies and low-intensity regimens. At JADPRO Live Virtual 2021, presenters reviewed novel and targeted oral chemotherapy for adults with AML and discussed multidisciplinary collaboration for patients with complex AML chemotherapy regimens.
Updates in the Diffuse Large B-Cell Lymphoma Treatment Landscape
Authors: Ames, FNP-BC Ashley , Lee, AGPCNP-BC Diane
Published: May 2022

During JADPRO Live Virtual 2021, presenters discussed updates in the treatment of diffuse large B-cell lymphoma (DLBCL), including novel agents and chimeric antigen receptor (CAR) T-cell therapy, and how the treatment and management of patients with DLBCL has been affected by the COVID-19 pandemic.
Thriving, Not Just Surviving: Recognizing Burnout and Simple Tips to Start Feeling Better
Authors: Leddy, PA-C, MMSc Margaret
Published: May 2022

Burnout has been prevalent since before COVID-19 and continues to affect a large portion of the health-care workforce. At JADPRO Live Virtual 2021, Margaret Leddy, PA-C, MMSc, defined burnout in the setting of the oncology/hematology advanced practice role, described symptoms you can recognize in yourself and others, and provided three tips to combat burnout.
A Call to Action: The Role of the Oncology AP in Equitable Cancer Care
Authors: Hoffner, MSN, ANP-BC, AOCNP Brianna , Epworth, ARNP Josh , Faiman, PhD, MSN, APRN-BC, AOCN, FAAN Beth , J. Niranjan, BPharm, MS, PhD Soumya
Published: May 2022

The COVID-19 pandemic has only further brought to light how racism, bias, and lack of equity can result in social injustice, morbidity, and mortality. A panel of four advanced practitioners convened at JADPRO Live Virtual 2021 to examine oncology advanced practitioners’ capacity for enhancing equitable cancer care in the domains of care coordination and communication, clinical trials, and acknowledging and mitigating bias.
Where East Meets West: On Some Locations of America
Authors: Rachwał Tadeusz
Published: May 2022

The paper offers a reading of the westward movement of the American frontier as a passage to an imaginary land in which the actual topographical displacement is accompanied by various, sometimes contradictory, images of the future. The settlers envisioned various Americas, the visions coming from their own experiences as well as from the stereotypically European projection of America as a paradise and as an object of possession. Such, sometimes contradictory, visions are noticeable in attempts at conceptualizing the frontier and its significance not only (explicitly) by Turner, but also less directly by such writers and thinkers as Thoreau, Whitman, or Bourne. Their Americas are in fact imaginary constructs reworking the encounter of East and West, frequently mixing not only discovery with invention, but also relocating, like Whitman in “Passage to India,” two of the cardinal directions of the world and thus, as it were, “transnationalizing” America.
The U.S.-Mexico Border as a Palimpsest in Ana Teresa Fernández’s Art
Authors: Antoszek Ewa
Published: May 2022

The question of land has always been crucial to Latinos/as living in the U.S., due to the series of historical events that resulted in “[t]erritorial dispossession and dislocation” (Pérez 147) that have particularly influenced this ethnic group and relegated them both literally and metaphorically towards the margin-the border. Consequently, the border has played a significant role in the Latinx discourse for a long time. The complexity of spatial-social relations increased with subsequent waves of immigrants from Mexico and other Latin American states. However, as Monika Kaup notes, being both “natives of the Southwest before the American conquest” and immigrants, Latinos/as in the U.S. constitute “a charter as well as an immigrant group” (Kaup 26). This double status of the group is reflected in Chicano/a literary and cultural productions through nation-based and immigrant paradigms (Kaup 26) that have been constructed in direct reference to the border, since “[b]eneath the surface of these models lie two different concepts of the border” (Kaup 10). Combined with the transformations in the discourse on space the concept of the border has undergone several re-definitions and the changing role of the border-from the demarcation line to more porous and permeable space has been reflected in numerous artistic productions by Latinx authors and artists. Those artistic productions illustrate the transformations of the space and address the aforementioned interplay between indigenous and immigrant paradigms often present in the discourse on the Mexican-American border. The purpose of this article is to analyze how the space of the border is (re-)visioned by Latina artist Ana Teresa Fernández, turning the border into a cultural palimpsest. It focuses mainly on Fernández’s Erasing the Border/Borrando La Frontera (2013), together with the community project of the same title, and selected paintings from her series Foreign Bodies (2013) and Pressing Matters (2013) in order to examine the aforementioned redefinitions of the border and its multiple roles. Fernández’s revisionist performances of the border both contribute to the ongoing debate on the still urgent and pressing problem of the U.S.-Mexico border and are also an apt reflection on the status quo of borders in general.
What Is “New” in Faulkner Criticism?
Authors: Maszewski Zbigniew
Published: May 2022

A review essay concerning approaches Faulkner’s fiction as a response to Taylor Hagood’s Following Faulkner: The Critical Response to Yoknapatawpha’s Architect.
Perfis de avaliação nas organizações do terceiro setor: implicações diferenciadas na aprendizagem organizacional
Authors: Lopes Mónica
Published: May 2022

Este artigo explora padrões de representações e práticas de avaliação nas organizações do terceiro setor (OTS) no quadro das relações de accountability. A estratégia de pesquisa assenta na análise interpretativa de entrevistas com 45 atores sociais dos campos da avaliação e do terceiro setor, e na aplicação de um inquérito por questionário a representantes de 575 OTS a operar em Portugal. A análise permite ponderar a implicação e relevância de uma diversidade de variáveis associadas quer ao ambiente interno, quer ao contexto institucional, na configuração das conceções e práticas de avaliação, e aferir sobre as barreiras e fatores potenciadores do papel da avaliação no reforço da missão das organizações. A composição de quatro perfis de avaliação distintos, a partir de procedimentos estatísticos exploratórios, e suas implicações diferenciadas na aprendizagem organizacional, permite lançar pistas importantes para a (re)definição das políticas públicas para o setor.
Tolerância zero ou eficácia nula? Políticas públicas e regulamentos desportivos para combater o match-fixing
Authors: De Cima César , Moriconi Marcelo
Published: May 2022

Com recurso a entrevistas semiestruturadas e análise de conteúdo, este artigo avalia e expõe a ineficácia da política de “tolerância zero” da UEFA, órgão máximo do futebol europeu, em induzir compliance nos jogadores de futebol, em Portugal, ao nível das práticas de match-fixing. A ênfase excessiva na ética individual, a externalização do fenómeno como um problema do crime organizado e a relutância em admitir falhas de governança interna são as principais razões explicativas. O artigo afirma que a regulamentação do futebol deve passar de uma lógica de compliance para políticas de enforcement.
Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice
Authors: Fielder Edward , Wan Tengfei , Alimohammadiha Ghazaleh , Ishaq Abbas , Low Evon , Weigand B Melanie , Kelly George , Parker Craig , Griffin Brigid , Jurk Diana , Korolchuk Viktor I , von Zglinicki Thomas , Miwa Satomi
Published: May 2022

Cancer survivors suffer from progressive frailty, multimorbidity, and premature morbidity. We hypothesise that therapy-induced senescence and senescence progression via bystander effects are significant causes of this premature ageing phenotype. Accordingly, the study addresses the question whether a short anti-senescence intervention is able to block progression of radiation-induced frailty and disability in a pre-clinical setting. Male mice were sublethally irradiated at 5 months of age and treated (or not) with either a senolytic drug (Navitoclax or dasatinib + quercetin) for 10 days or with the senostatic metformin for 10 weeks. Follow-up was for 1 year. Treatments commencing within a month after irradiation effectively reduced frailty progression (p<0.05) and improved muscle (p<0.01) and liver (p<0.05) function as well as short-term memory (p<0.05) until advanced age with no need for repeated interventions. Senolytic interventions that started late, after radiation-induced premature frailty was manifest, still had beneficial effects on frailty (p<0.05) and short-term memory (p<0.05). Metformin was similarly effective as senolytics. At therapeutically achievable concentrations, metformin acted as a senostatic neither via inhibition of mitochondrial complex I, nor via improvement of mitophagy or mitochondrial function, but by reducing non-mitochondrial reactive oxygen species production via NADPH oxidase 4 inhibition in senescent cells. Our study suggests that the progression of adverse long-term health and quality-of-life effects of radiation exposure, as experienced by cancer survivors, might be rescued by short-term adjuvant anti-senescence interventions.
De novo-designed transmembrane domains tune engineered receptor functions
Authors: Elazar Assaf , Chandler Nicholas J , Davey Ashleigh S , Weinstein Jonathan Y , Nguyen Julie V , Trenker Raphael , Cross Ryan S , Jenkins Misty R , Call Melissa J , Call Matthew E , Fleishman Sarel J
Published: May 2022

De novo-designed receptor transmembrane domains (TMDs) present opportunities for precise control of cellular receptor functions. We developed a de novo design strategy for generating programmed membrane proteins (proMPs): single-pass α-helical TMDs that self-assemble through computationally defined and crystallographically validated interfaces. We used these proMPs to program specific oligomeric interactions into a chimeric antigen receptor (CAR) that we expressed in mouse primary T cells and found that both in vitro CAR T cell cytokine release and in vivo antitumor activity scaled linearly with the oligomeric state encoded by the receptor TMD, from monomers up to tetramers. All programmed CARs stimulated substantially lower T cell cytokine release relative to the commonly used CD28 TMD, which we show elevated cytokine release through lateral recruitment of the endogenous T cell costimulatory receptor CD28. Precise design using orthogonal and modular TMDs thus provides a new way to program receptor structure and predictably tune activity for basic or applied synthetic biology.
Male rat leukocyte population dynamics predict a window for intervention in aging
Authors: Yanai Hagai , Dunn Christopher , Park Bongsoo , Coletta Christopher , McDevitt Ross A , McNeely Taylor , Leone Michael , Wersto Robert P , Perdue Kathy A , Beerman Isabel
Published: May 2022

Many age-associated changes in the human hematopoietic system have been reproduced in murine models; however, such changes have not been as robustly explored in rats despite the fact these larger rodents are more physiologically similar to humans. We examined peripheral blood of male F344 rats ranging from 3 to 27 months of age and found significant age-associated changes with distinct leukocyte population shifts. We report CD25+ CD4+ population frequency is a strong predictor of healthy aging, generate a model using blood parameters, and find rats with blood profiles that diverge from chronologic age indicate debility; thus, assessments of blood composition may be useful for non-lethal disease profiling or as a surrogate measure for efficacy of aging interventions. Importantly, blood parameters and DNA methylation alterations, defined distinct juncture points during aging, supporting a non-linear aging process. Our results suggest these inflection points are important considerations for aging interventions. Overall, we present rat blood aging metrics that can serve as a resource to evaluate health and the effects of interventions in a model system physiologically more reflective of humans.
The Lived Experiences of Beginning Teachers: An Odyssey
Authors: Mendoza Marissa
Published: May 2022

The attrition rates for beginning teachers have been high and widespread, which oftentimes resulted in a teacher shortage. This qualitative phenomenological study explored the lived experiences of beginning teachers during their first three years in teaching. Specifically, it digs a deeper understanding of the challenges beginning teachers face, such as classroom management, support received, differentiated instruction, and unexpected expectations. An in-depth interview was conducted to ten beginning junior high school teachers from public and private schools within DepEd Puerto Princesa. Member checking was done to validate the accuracy of the data and to establish credibility.  The four constructs of credibility, transferability, dependability, and confirmability were considered to substantiate trustworthiness. The study reveals that beginning teachers are mostly challenged by the behavior of the students in classroom management; get the needed support from their administrators, colleagues, students’ parents, and immediate families; find difficulty in differentiating instruction to address learner’s differences; and are overwhelmed by the enormous amount of paperwork, extra-curricular assignments and teaching subjects not in line with their specialization. Likewise, salary, lack of training and orientation, work environment, and workload emerged as minor themes. Thus, beginning teachers’ found their first three years as challenging, overwhelming, shocking, tiring, difficult, stressful, and struggle yet wonderful, exciting, fun, colorful, rewarding, and fulfilling.
Acceptability of Pili Pasta
Authors: Gonzales Maria Luisa , Nunez Sheila
Published: May 2022

The study appraised the acceptability of pili pasta in the 2nd District of Albay. It determined the status of pili products in the 2nd district of Albay, Philippines, the level of Acceptability, along with appearance, aroma, texture, and taste, the SWOT analysis and challenges encountered in its production, and Marketability along with the product, promotion, price, place and people, likewise, the signed agreement on the rank order of its Acceptability and Marketability. It is substantial to the Department of Tourism (DOT), food industry, culinary professors, and culinary students. It used descriptive-inferential and experimental methods in determining the responses from 176 respondents in 4 groups. Findings revealed that the most known pili products are sweets and candies. The product was analyzed using the SWOT analysis and is highly acceptable in terms of appearance, aroma, texture, and taste. It was also considered marketable for its product, promotion, price, place, and people. The four groups of respondents significantly agreed on the Acceptability of pili pasta when it comes to taste. While they disagree significantly concur on its Marketability for the reason that different categories of respondents have different perspectives when it comes to marketing strategy to use in promoting the product. Therefore, pili pasta is acceptable defending in its location of marketing it.
A Quaint Collation of Childhood Renal Neoplasms- Wilms and Beyond: Perspective of a Tertiary Care Hospital of Eastern India
Authors: Mandal Meghadipa , Mukherjee Sanghamitra , Das Tushar Kanti
Published: May 2022

Paediatric renal neoplasms are rarely encountered entities. Histopathology is essential in most of the cases, where there is significant degree of clinical and radiological overlap. Present series has 32 cases which aimed to evaluate clinical and pathologic spectrum of renal tumours in children. Nephrectomy specimens of renal neoplasms of children below 12 years of age were included. Haematoxylin and Eosin (H&E) staining and Immunohistochemistry (IHC) were done. Findings were tabulated in a master sheet along with other demographic variables, clinical histories and imaging findings. Abdominal lump was the commonest presentation. Wilms tumour was the major histologic variant (66%), followed by Congenital Mesoblastic Nephroma (13%). Anaplasia and advanced Children's Oncology Group (COG) staging were the adverse prognostic indicators. Clear Cell Sarcoma and Rhabdoid tumours were seen to have adverse outcomes, whereas Congenital Mesoblastic Nephroma, Multicystic Dysplastic Kidney and Paediatric Cystic Nephromas had overall favorable prognosis. Histopathology plays a key role for confirmatory opinion on nature of the neoplasm. Better understanding of these cases will increase the diagnostic accuracy with early implementation of definitive therapy.
Performance of Cluster Front Line Demonstrations on Integrated Crop Management in Red Gram (Cajanus cajan) Using Variety PRG-176 in Peddapalli District under North Agroclimatic Zone of Telangana State in India
Authors: Venkanna Y. , Rao B. Bhaskar , Srinivas A. , Vinayak R. , Naresh B.
Published: May 2022

The present study was conducted under CFLD at the farmers’ fields under the Krishi Vigyan Kendra (KVK), Ramagirikhilla, Peddapalli District operational area for three kharif seasons during 2016-17 to 2019-20 covering 169 locations. The demonstrated technology delineated the practices of improved selection (PRG-176), seed treatment with Rhizobium @ 250 g acre-I, soil application of Trichoderma viridii @ 2kg acre-I mixing with FYM @ one hundred kilo acre-I and plant protection measures with installation of pheromone traps @ four per acre, spraying of neem oil @one liter acre-I and Profenofos 50 EC @ 400ml acre-I. The result of demonstration showed higher productivity notably as 15.91 q ha-I compared to the farmers practice (13.42 q ha-I) with a mean increase of 19.50%. Technology index and technology gap values were 59.57 per cent and 4.08 q ha-I respectively. The results conjointly unconcealed that the typical increase within the net return with demonstration was 55248 Rs. ha-I and 40651 Rs. ha-I over farmers practice respectively. Similarly, mean benefit cost ratio was recorded with demonstration as 2.63 compared to farmers practice (2.18) throughout the years of trial. Adoption of improved technology as well as new selection, timely supply of essential inputs with correct steering by the human, frequent watching visits to fields diagnose the issues and take applicable corrective measures, field days etc., can be the contributive factors for prime yield with smart quality in all told demonstration plots.
Biotechnological Production of Carotenoid from Oleaginous Red yeast and Its Applications
Authors: Srivastava Niti , Srivastava Richa , Gaurav Kumar
Published: May 2022

The demand for carotenoids and their derivatives from natural sources is increasing rapidly due to public concern about food safety and health issues, and thus, carotenoid production from microbial fermentation is increasing significantly due to its ability to accumulate higher levels of carotene. Carotenoids, lipid-soluble pigments, are responsible for the vibrant colors in food and microorganisms. Carotenoids have the most important advantages in terms of antioxidant and anticancer activity. These possible applications are used for treating various diseases like xerophthalmia, keratomalacia, skin acne, breast cancer and tumor formation. They are widely used in the pharmaceutical, cosmetics and food industries. Due to the overall increase in the cost of carotenoids, carotenoids are produced in the pharmaceutical, food and cosmetics industries through chemical synthesis or extraction from plants. The oleaginous red yeast, Rhodotorula minuta, is well known for producing a high yield of carotenoids with a low production cost. Over the years, these carotenoids have been produced from oleaginous red yeast, using low-cost substrates or agricultural waste for cost-effective purposes. In this paper, we highlighted the production of carotenoids from oleaginous red yeast and its applications.
Effect of Weed Management Approaches on Weed Density and Weed Control Efficiency in Apple Nursery Plants Grafted on Clonal Rootstock
Authors: Haq Asrar Ul , Ali Angrej , Kumar Amit , Khan F. A. , Mir S. A. , Alie B. A.
Published: May 2022

Aims: The study aimed to evaluate the influence of different weed management approaches on weed density and weed control efficiency in apple nurseries.

Study Design: The experimental method used in this study was a Randomized Complete Block Design with seven treatments, each replicated three times.

Place and Duration of Study: The experiment was set up at the Experimental Farm, Division of Fruit Science, Faculty of Horticulture, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar Campus, Srinagar, Jammu and Kashmir, India during the year 2020.

Methodology: Seven weed management treatments i.e. manual weeding, pendimethalin @ 1 kg a.i. ha-1, pendimethalin @ 1 kg a.i. ha-1 + manual weeding, paddy straw mulch – 6 cm thick, black polyethylene mulch - 200 micron, weed-free and weedy check were tested in apple nursery (Apple cv. Silver) Spur grafted on M-9 T337 was used as plant material for the study. Weed flora, density, dry weight, and weed control efficiency were all observed and recorded.

Results: Among different weed management approaches tested, black polyethylene mulch (200 micron) resulted in the lowest weed density and weed dry weight, and the highest weed control efficiency followed by paddy straw mulch (6 cm thick) and pendimethalin @ 1 kg a.i. ha-1 + manual weeding.

Conclusion: In apple nurseries on clonal rootstock M9-T337, black polyethylene (200 micron) was determined to be the most effective weed control strategy for reducing weed density while increasing overall control efficiency.
Influence of Spacing and Varieties on Growth and Yield of Baby Corn (Zea mays L.)
Authors: Sai Maganti Vakula , Umesha C.
Published: May 2022

A field experiment was conducted during kharif, 2021 at Crop Research Farm, Department of Agronomy, SHUATS, Prayagraj (U. P). The soil of given experimental plot was sandy loam in texture, neutral in soil reaction (pH 7.1), low in organic carbon (0.36 %), available N (171.48 kg/ha), available P (15.2 kg/ha) and available K (232.5 kg/ha).The experiment was laid in Randomized Block Design with Ten treatments and three replications. The treatments are as follows, T1: G-5414 + 40 cm x 15 cm, T2­: G-5414 + 50 cm x 15 cm, T3: G-5414 + 60 cm x 15 cm, T4: G-5417 + 40 cm x 15 cm, T5: G-5417 + 50 cm x 15 cm, T6: G-5417 + 60 cm x 15 cm, T7: Shine-60 + 40 cm x 15 cm, T8: Shine-60 + 50 cm x 15 cm, T9: Shine-60 + 60 cm x 15 cm are used. The results showed that application of treatment Shine-60 + 60 x 15 cm was recorded highest plant height (172.38 cm), No. of leaves/Plant (12.75), Plant dry weight (90.00 g/plant) whereas, Crop Growth Rate (39.77 g/m2/day) and Relative Growth Rate (0.036 g/g/day) was recorded significantly highest in treatment G-5414 + 40 cm x 15 cm. However, No. of Cobs/Plant (2.82), length of the Cob/Plant (17.55 cm), Cob weight with husk (44.18 g), Cob weight without husk (17.94 g), Cob yield with husk (28.78 t/ha) and Cob yield without husk (6.87 t/ha) was obtained in the treatment of Shine-60 + 60 cm x 15 cm as compared to the other treatments.