bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancement of photoelectrochemical activity of SnS thin-film photoelectrodes using TiO2, Nb2O5, and Ta2O5 metal oxide layers
Authors: Vequizo Junie Jhon M. , Yokoyama Masanori , Ichimura Masaya , Yamakata Akira
Published: May 2016

Tin sulfide (SnS) fine photoelectrodes fabricated by three-step pulsed electrodeposition were active for H2 evolution. The incident-photon-conversion-efficiency increases from 900 nm and offers a good fit with the absorption spectrum. The activity was enhanced by 3.4, 3.0, and 1.8 times compared to bare SnS by loading Nb2O5, TiO2, and Ta2O5, respectively. Nb2O5 was most efficient because its conduction band is low enough to facilitate effective electron transfer from SnS; it also has sufficiently high potential for H2 evolution. The overall activity is determined by the competitive interfacial electron transfer between SnS/metal-oxide and metal-oxide/water. Therefore, constructing appropriate heterojunctions is necessary for further improving photoelectrochemical systems.
Incorporation of an invasive plant into a native insect herbivore food web
Authors: Schilthuizen Menno , Santos Pimenta Lúcia P. , Lammers Youri , Steenbergen Peter J. , Flohil Marco , Beveridge Nils G.P. , van Duijn Pieter T. , Meulblok Marjolein M. , Sosef Nils , van de Ven Robin , Werring Ralf , Beentjes Kevin K. , Meijer Kim , Vos Rutger A. , Vrieling Klaas , Gravendeel Barbara , Choi Young , Verpoorte Robert , Smit Chris , Beukeboom Leo W.
Published: May 2016

The integration of invasive species into native food webs represent multifarious dynamics of ecological and evolutionary processes. We document incorporation ofPrunus serotina(black cherry) into native insect food webs. We find thatP. serotinaharbours a herbivore community less dense but more diverse than its native relative,P. padus(bird cherry), with similar proportions of specialists and generalists. While herbivory onP. padusremained stable over the past century, that onP. serotinagradually doubled. We show thatP. serotinamay have evolved changes in investment in cyanogenic glycosides compared with its native range. In the leaf beetleGonioctena quinquepunctata, recently shifted from nativeSorbus aucupariatoP. serotina, we find divergent host preferences onSorbus- versusPrunus-derived populations, and weak host-specific differentiation among 380 individuals genotyped for 119 SNP loci. We conclude that evolutionary processes may generate a specialized herbivore community on an invasive plant, allowing prognoses of reduced invasiveness over time. On the basis of the results presented here, we would like to caution that manual control might have the adverse effect of a slowing down of processes of adaptation, and a delay in the decline of the invasive character ofP. serotina.
Association of potential salivary biomarkers with diabetic retinopathy and its severity in type-2 diabetes mellitus: a proteomic analysis by mass spectrometry
Authors: Chee Chin Soon , Chang Khai Meng , Loke Mun Fai , Angela Loo Voon Pei , Subrayan Visvaraja
Published: May 2016

Aim/hypothesis:The aim of our study was to characterize the human salivary proteome and determine the changes in protein expression in two different stages of diabetic retinopathy with type-2 diabetes mellitus: (1) with non-proliferative diabetic retinopathy (NPDR) and (2) with proliferative diabetic retinopathy (PDR). Type-2 diabetes mellitus without diabetic retinopathy (XDR) was designated as control.

Method:In this study, 45 saliva samples were collected (15 samples from XDR control group, 15 samples from NPDR disease group and 15 samples from PDR disease group). Salivary proteins were extracted, reduced, alkylated, trypsin digested and labeled with an isobaric tag for relative and absolute quantitation (iTRAQ) before being analyzed by an Orbitrap fusion tribrid mass spectrometer. Protein annotation, fold change calculation and statistical analysis were interrogated by Proteome Discoverer. Biological pathway analysis was performed by Ingenuity Pathway Analysis. Data are available via ProteomeXchange with identifiersPXD003723–PX003725.

Results:A total of 315 proteins were identified from the salivary proteome and 119 proteins were found to be differentially expressed. The differentially expressed proteins from the NPDR disease group and the PDR disease group were assigned to respective canonical pathways indicating increased Liver X receptor/Retinoid X receptor (LXR/RXR) activation, Farnesoid X receptor/Retinoid X receptor (FXR/RXR) activation, acute phase response signaling, sucrose degradation V and regulation of actin-based motility by Rho in the PDR disease group compared to the NPDR disease group.

Conclusions/Interpretation:Progression from non-proliferative to proliferative retinopathy in type-2 diabetic patients is a complex multi-mechanism and systemic process. Furthermore, saliva was shown to be a feasible alternative sample source for diabetic retinopathy biomarkers.
Development of Innovation Process Model Using S-BPM Approach
Authors: GROMOFF ALEXANDER , STAVENKO JULIA , EVINA KRISTINA , KAZANTSEV NIKOLAY
Published: May 2016

The innovation process management increasingly gains importance due to tough competition and constantly changing business external and internal environments. In this article, diﬀerent approaches to the innovation process management are compared. Then some requirements of implementing and managing innovation processes are introduced considering the ad-hoc nature of innovation activities. After that overall innovation process model is proposed with incorporation of expert communities consisting of internal and external experts among employees, suppliers, consumers, research institutions and competitors. As a result a flexible and useful innovation process model is presented based on a theoretical framework, empirical studies and S-BPM approach. The given research was held in a frame of the contract № 13.G25.31.0096 with the Ministry for Education and Science of Russian Federation «Creation of hi-tech manufacture of unstructured information processing in cross-platform system on the open source software basis in order to increase management efficiency of innovative activity of enterprises in modern Russia».Keywords: Business Management, Innovation, innovator, innovative process, expert,s-bpm, descriptive design, Moscow, Russia
Synergising for Quality Improvement of Business and Management: International Publications in Asian Countries
Authors: SURYANI TATIK
Published: May 2016

Journal publications, particularly in the areas of business, management, and accounting need to be improved, not only in quantity but also the quality so that they have long-term usefulness and they can be utilized by other researchers or by public. The number of citations is viewed as one measurement of the quality of a scientific journal. The efforts that encourage quality improvement of the journals also increase the citation number. Again, taking into account the low number of journals in the fields of business, management, and accounting, in the countries of Asia and Southeast Asia, the collaboration and synergy among researchers, research institutions, and publishers is really important. Collaboration and synergy can be stimulated through various conferences and networking done in or during the conferences. Such collaboration can be done and beneficial when it is based on the principle of partnership and mutual benefit.Keywords: Business and Management, quality of journal publication, traditional approach,citation, Surabaya, Indonesia
Sales Impacts of Customer Retention: A Strategic Assessment on Potential Retention of College Students
Authors: LINDIAWATI LINDIAWATI
Published: May 2016

the private colleges is important since the students may decide to leave for other colleges or universities at the beginning semester. This study is to evaluate the potential retention of college students newly recruited by a college. This researchsurveyed 112 new students of STIE Perbanas Surabaya. The sampling was convenient sampling technique. The questionnaire was mostly filled up by the students from out of East Java especially out of Java Island. It was analyzed using descriptive statistic, Excel of Microsoft 2007. The results showed that a) 100% of students are willing to make positive word-of-mouth advertising; b) 96.1% showed that they often talked about positiveness of their college; c) 93.5% showed that they often heard from other students on the positiveness of their college; d) 93.1% students are willing to help in promotion activities; 83.7% showed that they were happy in studying in the college. This internal survey is a strategic business analysis since the result of the research is a substance that should strategically be analyzed for the top management consideration in issuing policies for the college sustainability.Keywords: Marketing Management, Customer retention, Sales Impacts, Customer ValueAnalysis, College Students Retention, strategic business, descriptive research,Surabaya, Indonesia
Firm Size as Predictor of Compliance to International Financial Reporting Standards (IFRS) 8
Authors: SUCUAHI WILLIAM T.
Published: May 2016

Globalization and diversification are the trends of business nowadays. Companies’ diversification will lead to complexity of financial information and investment decision. The objective of this study is to determine the level of compliance with International Financial Reporting Standard (IFRS) 8 and to determine other related segment information to formulate investment strategies. The subjects of the research were the 100 diversified publicly-listed holding companies in the Philippines with 2010-2011 annual financial reports. Segment Disclosure Index (SDI) was developed to determine the level of compliance with IFRS 8. The study used firm size, company age, audit quality, profitability, leverage, growth and industry as predictors of the level of compliance. The result shows high overall level of compliance with IFRS 8 – Operating segment. Using multiple regression analysis, it was found out that only firm size predicts the level of compliance with IFRS 8. Large companies mostly comply with disclosure requirement stated in IFRS 8 compared to smaller companies. Most of the companies are engaged in real estate development and leasing business.Keywords: Business and Management, accounting, IFRS 8, disclosure, segment reporting,descriptive design, Philippines2
The High Levels of Professionalism of the Philippine National Police Officers in Southern Mindanao, Philippines
Authors: CHAVEZ CARMELITA B.
Published: May 2016

Organizational efforts in the PNP are focused on reforms and improvement,emphasizing specialization, professionalism, commitment and community serviceorientation.Extensive trainings are given for the PNP to gain skills and imbuewith them the values of commitment and dedication to service. The study aimedto analyze the strengths, weaknesses, opportunities, and threats of the PNP andits impact on the PNP mission statement. The study used descriptive-normativesurvey using questionnaire and documentary analysis to gather data from thePolice Commissioned Officers (PCO) and Police Non-Commissioned Officers.Both indicated well organized, strong, dedicated and committed professionalPNP personnel, while there were still graft and corruption, inadequate facilities,coordinative mechanism among law enforcement agencies, and internalization ofthe mission statement, and political interventions. The following were threats of thePNP: political interventions, harassment charges, narcotics abuse and trafficking, andmisleading media. Results showed that there are still opportunities to improve thelegal system and opportunities to change police career due to good experience andexposure. The study concluded that the SWOT model has a very high impact ofthe mission statements of the PNP particularly on community safety, communitypartnership, environment, gender development, material and financial management,human resource development and job satisfaction.Keywords: Multidisciplinary Research, High levels of professionalism of the PNP,Descriptive-normative survey research, Southern Mindanao, Philippines
Looking Ahead: Scanning Change Management and its Implications to Human Resource Management Practices
Authors: GERNAL LIZA M. , SERGIO ROMMEL P. , SHUALI MOHAMMAD AL
Published: May 2016

Oman’s vision for the coming decades is to raise the skill level andcompetencies of the Omani labour force. To achieve this goal, it is imperative todevelop human resource management practices that are aligned with the values,beliefs and preferences of the Omani workforce but which support the visionof a high-skilled economy. This study aims to assess the Omanization programand its policies, to examine the change management of Omani employees interms of wide-range strategic approaches, and to provide critical evaluations inpublic offices in terms of approaches to respond to the changing global needs andits implications to human resource management practices through qualitative descriptive research method of analysis. The secondary data contributed to thechange management literature by examining the cultural orientations of Omaniemployees and by linking them to their preferences of HRM policies and practicesin a telecommunication setting. The study reveals that the Omanization policiesare introduced to tap human resource management development programs invarious areas in both public and private sectors. Change management programsutilize strategic training as a distinct approach to capture desired strategic changeframeworks in 2020. Recommendations in line with the drawn conclusions arealso introduced in this study.Keywords: Change management, human resource management policies and practices,qualitative-descriptive research method, Oman
Diversity Climate and Affective Commitment of Teachers in Tertiary Schools
Authors: PORALAN PORFERIA S. , SOLOMON JO-ANN Y.
Published: May 2016

Commitment as an important factor in any school organization spells thedifference between success and failure in any educational undertaking. Teachers’commitment is closely connected with teaching performance. This studydetermined the relationship between diversity climate and affective commitmentof teachers in tertiary schools in Davao Region. The research design used wasdescriptive-correlational. It investigated the relationship of diversity climatecharacterized by individual practices, work group practices and organizationalpractices and affective commitment categorized as organizational support, organizational commitment, organizational reward, procedural justice and direct supervisor support. A modified questionnaire was used in the collectionof data. Data were treated using descriptive statistics such as percentage, meanand standard deviation, ANOVA, t-test and Pearson’s r correlation. The resultsof the study showed that the level of diversity climate and affective commitmentof teachers among tertiary school is high. The perception of teachers on diversity climate and the level of affective commitment do not differ significantly whenit was analyzed using the respondent profile though a significant difference wasnoted between gender and affective commitment. The data also revealed thatdiversity climate is statistically related to the affective commitment of teacher.Keywords: Management, Organizational culture, diversity climate, affectivecommitment, teachers, tertiary schools, descriptive-correlational design, DavaoCity, Philippines
Correlation of Teacher Education Graduates’ Academic Performance, Licensure Examination Performance, Type of Work and Waiting Time for Job Search
Authors: Dangan Shirley D.
Published: May 2016

Graduates’ performance in licensure examination and their employability are key performance indicators in quality assurance. The quality of teacher education curriculum offered by universities is measured by the graduates’ performance in the licensure examination for teachers and their employability in teaching. A teacher education graduate must have a valid professional license to be employed as teacher. This study determined the relationships of the teacher education graduates’ academic performance, rating in the licensure examination for teachers, type of work and waiting time for job search. A descriptive-correlational research design was used to study the direction and magnitude of the relationship between the variables involved in the study. One hundred sixty-four teacher education graduates of Palawan State University Cuyo Campus were involved as respondents. Descriptive survey and documentary analysis technique were employed in gathering data. The statistical analysis of data revealed significant relationships between the teacher education graduates’ academic performance, rating in the licensure examination for teachers, type of work and waiting time for job search. Licensure tests increase the costs of entering an occupation and a failure rate lengthens the waiting time for job search and creates uncertainty about obtaining employment.   Keywords - Licensure Examination for Teachers (LET), Academic Performance, Type of Work, Waiting Time for Job Search
MATRIMONIO HOMOSEXUAL, OPOSICIÓN RELIGIOSA Y OBJECIÓN DE CONCIENCIA EN ARGENTINA. A CINCO AÑOS DE LA LEY DE MATRIMONIO IGUALITARIO
Authors:   Universidad de Zaragoza (España), Arlettaz Fernando
Published: May 2016

La ley de 2010 que introdujo el matrimonio entre personas del mismo sexo en el derecho argentino muestra la progresiva secularización del matrimonio. El nuevo Código Civil, en vigor desde 2015, mantiene la posibilidad del matrimonio homosexual y además regula otra figura (la de las uniones convivenciales) que profundiza la secularización de las relaciones de familia. La reivindicación de la objeción de conciencia a intervenir en la celebración de los matrimonios homosexuales que se dio junto con los debates en torno de la ley parece haberse desvanecido con el paso del tiempo. Sin perjuicio del dictado de normas que, con un criterio pragmático, resuelvan los conflictos que puedan plantearse, la posibilidad de objeción debe ser considerada con criterio restrictivo.
OBJECIÓN DE CONCIENCIA A LA EUTANASIA
Authors:   Universidad de La Sabana (Bogotá, Colombia), Prieto Vicente
Published: May 2016

Con la sentencia C 239 de 1997 la Corte Constitucional legalizó en Colombia la práctica de la eutanasia. En la sentencia T 970 de 2014, de la misma Corte, y en la Resolución 1216 de 2015, del Ministerio de Salud, se emitieron disposiciones más concretas, entre las cuales destaca el reconocimiento de la objeción de conciencia. La nueva normativa, sin embargo, adolece de graves deficiencias en el reconocimiento del derecho a objetar de las personas, distintas del médico que lleva a cabo la eutanasia, que cooperan de algún modo en su práctica (personal sanitario y administrativo). Algo similar ocurre con el derecho de las instituciones privadas de salud a no realizar prácticas contrarias a su ideario institucional (ético o religioso).
SITUACIÓN ACTUAL DE LA OBJECIÓN DE CONCIENCIA EN MÉXICO
Authors:   Universidad Iberoamericana (México), Patiño Reyes Alberto
Published: May 2016

Este escrito examina el régimen de la legislación nacional mexicana a los sucesos conocidos como objeción de conciencia, el momento en que una persona encara a un conflicto derivado de sus convicciones morales, ya sean religiosas o éticas, con la observancia de un imperativo legal que la conmina a optar entre desatender a la ley o contravenir a su conciencia. El autor ha sido testigo del primer reconocimiento legal a la objeción de conciencia en el estado de Jalisco a los tratamientos médicos, pasando por la reciente propuesta de reforma legal para permitir la objeción de conciencia al servicio militar obligatorio, hasta la posibilidad de plantear la objeción de conciencia de funcionarios y jueces.
EL PAPEL DE LA RELIGIÓN Y LA LIBERTAD RELIGIOSA PARA MEJORAR EL DESARROLLO: UNA PERSPECTIVA LATINOAMERICANA
Authors:   Universidad de Montevideo (Uruguay), Asiaín Pereira Carmen
Published: May 2016

Proposición: Desde un punto de vista ético, a la hora de abordar los Derechos Religiosos y Desarrollo Económico, se hace inevitable. Desde la perspectiva latinoamericana, se destacan las principales preocupaciones en dos áreas: 1. Las demandas de ajustes razonables en el lugar de trabajo, basadas en la libertad religiosa (fiestas religiosas, las tareas rechazadas sobre la base de la libertad de conciencia en materia de salud y educación, vestimenta religiosa) trabajadores que impacto y los empleadores. 2. Las demandas de las empresas -ya sea con o sin ánimo de lucro que soliciten exenciones (de impuestos o derechos afirmativas) del Estado en los ámbitos de salud y educación. Esto implica, el deber del Estado de respetar el pluralismo, la democracia y la neutralidad. Una reflexión final sobre la responsabilidad agravada, de dos tomadores de decisiones (empleadores -empresas y el Estado) como líderes de gestión y los líderes de opinión, desde el punto de vista ético y también jurídico
Arte popular criativa e turismo cultural na cidade de Loulé (Algarve/Portugal)
Authors: Santos Jean Carlos Vieira , Silva João Albino
Published: May 2016

Este trabalho aborda a arte popular criativa como oferta complementar ao produto “turismo cultural” em espaço urbano, uma experiência que tem como chave interpretativa o descobrimento das reflexões e interpretações acerca da inovação estratégica do produto artesanal na cidade de Loulé, na região Algarve, em Portugal. Sob esse pressuposto, interessa-nos aqui não a descrição dos artesãos e artesanatos, mas a discussão acerca da relação entre arte popular e criatividade, uma abordagem integrada nas tendências do turismo cultural. Nesse contexto, o artigo traz o exemplo do projeto de Técnicas Ancestrais e Soluções Atuais (TASA). Desse modo, considera-se como método a subjetividade das entrevistas e dos trabalhos de campo, por meio dos quais foi possível observar as situações do cotidiano, os espaços e lugares dos artesãos com sua arte popular criativa. O texto traz argumentos e análises acerca do turismo nos contextos cultural e criativo e na experiência de valorização da arte popular em Loulé.
Prenatally Diagnosed Cases of Binder Phenotype Complicated by Respiratory Distress in the Immediate Postnatal Period
Authors: Blumenfeld Yair J. , Davis Alexis S. , Hintz Susan R. , Milan Kristina , Messner Anna H. , Barth Richard A. , Hudgins Louanne , Chueh Jane , Homeyer Margaret , Bernstein Jonathan A. , Enns Gregory , Atwal Paldeep , Manning Melanie
Published: May 2016

Binder phenotype, or maxillonasal dysostosis, is a distinctive pattern of facial development characterized by a short nose with a flat nasal bridge, an acute nasolabial angle, a short columella, a convex upper lip, and class III malocclusion. We report 3 cases of prenatally diagnosed Binder phenotype associated with perinatal respiratory impairment.
Percutaneous Ultrasound‐Guided TOPAZ Radiofrequency Coblation
Authors: Shah Amit , Best Alistair J. , Rennie Winston J.
Published: May 2016

Various therapeutic options are available for treatment of recalcitrant plantar fasciitis. Studies using TOPAZ coblation (ArthroCare, Sunnyvale, CA) have had good early results. The current coblation technique involves a surgical incision or breach of the highly specialized plantar fat pad, which can be associated with risks. We describe a novel technique of ultrasound‐guided percutaneous coblation with a lateral heel approach. Advantages include precise targeting of the plantar fascia by direct dynamic visualization of the coblation tip, a true percutaneous approach with a needle skin puncture (<5 mm), and preservation of the plantar fat pad by using a lateral heel approach.
Nkx6.1‐mediated insulin secretion and β‐cell proliferation is dependent on upregulation of c‐Fos
Authors: Ray Jason D. , Kener Kyle B. , Bitner Benjamin F. , Wright Brent J. , Ballard Matthew S. , Barrett Emily J. , Hill Jonathon T. , Moss Larry G. , Tessem Jeffery S.
Published: May 2016

Understanding the molecular pathways that enhance β‐cell proliferation, survival, and insulin secretion may be useful to improve treatments for diabetes. Nkx6.1 induces proliferation through the Nr4a nuclear receptors, and improves insulin secretion and survival through the peptide hormone VGF. Here we demonstrate that Nkx6.1‐mediated upregulation of Nr4a1, Nr4a3, and VGF is dependent on c‐Fos expression. c‐Fos overexpression results in activation of Nkx6.1 responsive genes and increases β‐cell proliferation, insulin secretion, and cellular survival. c‐Fos knockdown impedes Nkx6.1‐mediated β‐cell proliferation and insulin secretion. These data demonstrate that c‐Fos is critical for Nkx6.1‐mediated expansion of functional β‐cell mass.
Heat flow along the Costa Rica Seismogenesis Project drilling transect: Implications for hydrothermal and seismic processes
Authors: Hass Bridget , Harris Robert N.
Published: May 2016

Heat flow analysis of the Costa Rica convergent margin is carried out for seven sites drilled during Integrated Ocean Drilling Program (IODP) Expeditions 334 and 344 as part of the Costa Rica Seismogenesis Project (CRISP). These expeditions are designed to better understand erosional subduction zones. Heat flow measurements were made to improve estimates of the thermal structure of this erosive margin and are located on the incoming plate, toe, lower, middle, and upper slopes of the margin. Heat flow values corrected for the effects of seafloor bathymetry and sedimentation are on average 15% higher than uncorrected values and range from approximately 158–200 mW/m2 on the incoming plate to values of approximately 50 mW/m2 on the middle and upper slopes of the margin. These values are consistent with previous estimates of heat flow showing a landward decrease in heat flow consistent with subduction of the Cocos plate. Preferred thermal models of the shallow subduction zone successfully predicting observed values of heat flow incorporate fluid flow within the upper oceanic aquifer have an uppermost permeability of 10−9.5 m2 and a plate boundary effective coefficient of friction of 0.06. These models suggest that temperatures on the subduction thrust reach 100°C at distances between 30 and 35 km landward of the deformation front. The updip limit of seismicity, as defined by aftershocks events of ML 1–4 recorded following the Mw 6.9 Quepos earthquake, occurs at 25 km landward of the deformation front at temperatures cooler than the 100–150°C typically predicted.
Special cases in Cornelia de Lange syndrome: The Spanish experience
Authors: Pié Juan , Puisac Beatriz , Hernández‐Marcos Maria , Teresa‐Rodrigo Maria Esperanza , Gil‐Rodríguez Maria , Baquero‐Montoya Carolina , Ramos‐Cáceres Maria , Bernal Maria , Ayerza‐Casas Ariadna , Bueno Inés , Gómez‐Puertas Paulino , Ramos Feliciano J.
Published: May 2016

Cornelia de Lange Syndrome (CdLS) is an autosomal dominant (NIPBL, SMC3, and RAD21) or X‐linked (SMC1A and HDAC8) disorder, characterized by distinctive craniofacial appearance, growth retardation, intellectual disability, and limb anomalies. In 2005, the Spanish CdLS Reference Center was started and now we have more than 270 cases in our database. In this special issue, we describe some of the unique or atypical patients studied by our group, whose clinical features have contributed to the expansion of the CdLS classical phenotype, helping clinicians to diagnose it. We include the case of a male with unilateral tibial hypoplasia and peroneal agenesis who had a mutation in NIPBL; we also describe one patient with a mutation in NIPBL and somatic mosaicism identified by new generation sequencing techniques; we also include one patient with CdLS and Turner syndrome; and last, an interesting patient with a duplication of the SMC1A gene. Finally, we make a short review of the splicing mutations we have found in NIPBL regarding the new knowledge on the physiological variants of the gene. © 2016 Wiley Periodicals, Inc.
Attitudes about the use of internet support groups and the impact among parents of children with Cornelia de Lange syndrome
Authors: Cacioppo Cara N. , Conway Laura J. , Mehta Devanshi , Krantz Ian D. , Noon Sarah E.
Published: May 2016

There is an abundance of information in the literature on patient experiences with Internet support groups (ISGs). However, studies exploring these experiences in a rare disease population are scarce, even though these families are often at a disadvantage for resources, reliable information, and support. The aim of the current study was to explore the experiences with ISGs for parents of children with Cornelia de Lange syndrome (CdLS), a rare genetic diagnosis, in order to better understand the impact on emotional support and their child's medical care. Focus groups were conducted to inform the design of a large‐scale internet survey. The survey asked parents closed‐ and open‐ended questions regarding experiences with ISGs, with a focus on the psychosocial, medical, and logistical aspects. The survey found that 141/170 (82.6%) respondents have visited an Internet‐based support group to find support or information about their child's CdLS diagnosis. The majority of respondents (71.7%) reported that ISGs have been helpful in finding emotional support, with the most common areas impacted as a result of ISG participation being behavior toward their children and family dynamic. Regarding medical care, most respondents (63.9%) reported that ISGs have been helpful in finding medical information and support, with the most commonly impacted areas of their child's care including day‐to‐day management, diet, therapy interventions, and healthcare providers. These findings provide a greater understanding of the role of Internet networking in healthcare and may inform future approaches to medical care and psychosocial support for rare, complex genetic diagnoses. © 2016 Wiley Periodicals, Inc.
Parallele chemische Proteinsynthese auf der Oberfläche zur schnellen Analyse der Phosphoregulierung von SH3‐Domänen
Authors: Zitterbart Robert , Seitz Oliver
Published: May 2016

Mangelnde Verfügbarkeit erschwert die Analyse posttranslational modifizierter Proteindomänen, denn rekombinante Methoden vermitteln nur selten die gewünschte Ortsspezifität. Die Totalsynthese ermöglicht zwar eine nahezu vollkommene Kontrolle über posttranslationale und andere Modifikationen, jedoch bleiben chemische Methoden auf kürzere Peptide beschränkt. Zur Lösung dieses Problems präsentieren wir hier eine Methode, die a) Immobilisierung N‐terminaler Thio‐Peptidhydrazide über Hydrazonverknüpfung, b) native chemische Ligation auf der Oberfläche mit selbstgereinigten Peptidthioestern c) radikalisch induzierte Entschwefelung und d) einen oberflächenbasierten Fluoreszenzbindungs‐Assay zur funktionellen Charakterisierung kombiniert. Die Methode wurde zur schnellen Untersuchung von 20 SH3‐Domänen verwendet. Die Analyse lässt schließen, dass Tyrosinphosphorylierung der SH3‐Domänen in Abl‐Kinasen als Schalter fungiert, der sowohl einen Verlust als auch einen Gewinn an Affinität für prolinreiche Liganden induzieren kann.
The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex
Authors: Salvi Nicola , Papadopoulos Evangelos , Blackledge Martin , Wagner Gerhard
Published: May 2016

Lack of regulation of the interaction between the eIF4E/eIF4G subunits of the translation initiation factor complex eIF4F is a hallmark of cancer. The inhibitor 4EGI‐1 binds to eIF4E, thereby preventing association with eIF4G through an allosteric mechanism. NMR spectroscopy and MD simulations were used to obtain a mechanistic description of the role of correlated dynamics in this allosteric regulation. We show that binding of 4EGI‐1 perturbs native correlated motions and increases correlated fluctuations in part of the eIF4G binding site.
A Formal Enantiospecific Synthesis of 7,20‐Diisocyanoadociane
Authors: Roosen Philipp C. , Vanderwal Christopher D.
Published: May 2016

7,20‐Diisocyanoadociane (DICA) is a potent antimalarial isocyanoterpene endowed with a fascinating tetracyclic structure composed of fused chair cyclohexanes. We report a highly stereocontrolled synthesis of a late‐stage intermediate, the “Corey dione”, from which DICA has been made previously. This formal synthesis features a rapid buildup of much of the complexity of the target through a sequence of enone tandem vicinal difunctionalization, Friedel–Crafts cyclodehydration, and sequential stereocontrolled reductions. Most importantly, this success establishes the broader feasibility of our previously developed general synthesis approach to the isocyanoterpene family and provides a blueprint for a very direct synthesis of DICA and related natural products.
Model‐based optimization of the feeding policy of a fluidized bed bioreactor for mercury uptake by immobilized Pseudomonas putida cells
Authors: Şcoban Andreea Georgiana , Maria Gheorghe
Published: May 2016

A model‐based analysis of a three‐phase continuously operated fluidized bed bioreactor is developed in order to determine the multi‐objective optimal feeding policy of the immobilized biomass used for removing mercury ions from wastewater. The analysis is focus on finding the optimal feeding policy of alginate porous beads of known particle size containing immobilized biomass (Pseudomonas putida bacteria) to minimize the biomass consumption, while keeping a quasi‐constant high conversion. The extended bioreactor model is accounting for the biomass growth, biodegradation, and its partial leakage and washout. Bioreactor dynamics prediction has been generated by using a simple Michaelis–Menten kinetic model adopted from literature. The resulted optimal feeding policy of the bioreactor points out the importance of the adoption of an extended and adequate process/reactor model able to solve engineering operation problems by quickly adjusting the feeding conditions according to the time‐varying characteristics of the biomass culture and to the limited possibilities to control the process during the wastewater residence time in the bioreactor. © 2016 Curtin University of Technology and John Wiley & Sons, Ltd.
Production of an anti‐Candida peptide via fed batch and ion exchange chromatography
Authors: Mukherjee Rudra Palash , Beitle Robert , Jayanthi Srinivas , Kumar T.K.S. , McNabb David S.
Published: May 2016

Interest in peptides as diagnostic and therapeutic materials require their manufacture via either a recombinant or synthetic route. This study examined the former, where a recombinant fusion consisting of an antifungal peptide was expressed and isolated from Escherichia coli. Fed batch fermentation with E. coli harboring an arabinose‐inducible plasmid produced the 12 residue anti‐Candida peptide fused to the N‐terminal of Green Fluorescent Protein (GFPUV). The purification of the fusion protein, using ion‐exchange chromatography, was monitored by using the intrinsic fluorescence of GFPUV. The recombinant antifungal peptide was successfully released by cyanogen bromide‐induced cleavage of the fusion protein. The recombinant peptide showed the expected antifungal activity. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:865–871, 2016
Eremophilane Sesquiterpenes from the Genus Ligularia
Authors: Wu Ling , Liao Zhixin , Liu Chao , Jia Haiyang , Sun Jinyue
Published: May 2016

Ligularia speices are widely used in Asian folk medicines for the treatment of various human diseases. Eremophilane‐type sesquiterpenes are abundant and typical secondary metabolites found in this genus. Over 500 eremophilanes reported from members of Ligularia are reviewed in this article together with bioactivity data in an effort to highlight the development in this field.
Decomposition of Fluorinated Graphene under Heat Treatment
Authors: Plšek Jan , Drogowska Karolina Anna , Valeš Václav , Ek Weis Johan , Kalbac Martin
Published: May 2016

Fluorination modifies the electronic properties of graphene, and thus it can be used to provide material with on‐demand properties. However, the thermal stability of fluorinated graphene is crucial for any application in electronic devices. Herein, X‐ray photoelectron spectroscopy (XPS), temperature‐programmed desorption (TPD), and Raman spectroscopy were used to address the impact of the thermal treatment on fluorinated graphene. The annealing, at up to 700 K, caused gradual loss of fluorine and carbon, as was demonstrated by XPS. This loss was associated with broad desorption of CO and HF species, as monitored by TPD. The minor single desorption peak of CF species at 670 K is suggested to rationalize defect formation in the fluorinated graphene layer during the heating. However, fluorine removal from graphene was not complete, as some fraction of strongly bonded fluorine can persist despite heating to 1000 K. The role of intercalated H2O and OH species in the defluorination process is emphasised.
ChemInform Abstract: Boundary Layer Chemical Diffusion und Lattice Parameter of Undoped und Cr‐ Doped NiO.
Authors: NOWOTNY J. , SADOWSKI A.
Published: May 2016

Es wird die Oberflächenkinetik von undotiertem, Cr‐dotiertem NiO und einer NiCr2O4‐Spinellphase untersucht.
ChemInform Abstract: A ROTATING RING‐DISK STUDY OF THE ALUMINUM ELECTRODE IN MOLTEN ALUMINUM CHLORIDE + SODIUM CHLORIDE + POTASSIUM CHLORIDE ELECTROLYTES
Authors: TAKAHASHI S. , KOURA N.
Published: May 2016

Die RRDE‐Untersuchungen im Titelelektrolyten sollen Aufschluß über die Elektrodenkinetik, bisher wurde eine 3‐Elektronen‐Reaktion angenommen, und über die gebildeten Zwischenverbindungen geben.
ChemInform Abstract: REACTION OF NITRIC OXIDE WITH HYPONITROUS ACID: A HYDROGEN ATOM ABSTRACTION REACTION
Authors: AKHTAR M. J. , BONNER F. T. , HUGHES M. N.
Published: May 2016

Um zu prüfen, ob eine direkte NO ‐ HzNzOz‐Reaktion erfolgt, werden die Produkte des HzNzOz‐Zerfalls in 5 M HClO4 durch Gaschromatographie mit CF4 als Referenzgas analysiert.
ChemInform Abstract: SYNTHESIS OF BARIUM TANTALATE‐BASED SOLID SOLUTIONS IN SALT MELTS
Authors: NALBANDYAN V. I. , BELYAEV I. N. , LUPEIKO T. G. , NALBANDYAN V. B.
Published: May 2016

Aus MCO, (M: Ba, Sr, Ca) und TiO2 können in Schmelzen von NaKCO3 bei verhältnismäßig niedriger Temp. (1070 K) und in hoher Ausb., Reinheit und Homogenität nicht nur die Titanate MTiO3 dargestellt werden, sondern auch homogene feste Lösungen der Zusammensetzung Ba"‐")Sr"TiO3 (x = 0.15 und 0.35).
ChemInform Abstract: TAUTOMERIC NATURE OF QUINONOID 6,7‐DIMETHYL‐7,8‐DIHYDRO‐6H‐PTERIN IN AQUEOUS SOLUTION: A NITROGEN‐15 NMR STUDY
Authors: BENKOVIC S. J. , SAMMONS D. , ARMAREGO W. L. F. , WARING P. , INNERS R.
Published: May 2016

Durch spezifische ′SN‐ und zH‐Dotierung werden einige Derivate der Titelverbindung NMR‐spektroskopisch untersucht.
ChemInform Abstract: Host‐Guest Complexation. Part 35. Spherands, the First Completely Preorganized Ligand System.
Authors: CRAM D. J. , KANEDA T. , HELGESON R. C. , BROWN S. B. , KNOBLER C. B. , MAVERICK E. , TRUEBLOOD K. N.
Published: May 2016

Die Spheranden (Ia), (II) und (III) sowie der verwandte Makrocyclus (Ib) werden dargestellt (ausführliche Beschreibung im Experimentalteil); der kritische Ringschluß erfolgt am besten durch entsprechende Dibrombiphenyle, die mit sBuLi (teilweise auch, weniger gut, mit BuLi) lithiiert und anschließend mit Fe(acac)3 oxidiert werden (Ringschluß‐Kupplung der zunächst entstehenden Arylradikale).
ChemInform Abstract: STABLE SIMPLE ENOLS. 11. EQUILIBRIUM CONSTANTS FOR THE 1‐ALKYL‐2,2‐DIMESITYLETHENOL/1‐ALKYL‐2,2‐DIMESITYLETHANONE SYSTEMS IN HEXANE. THE PREDOMINANCE OF STERIC EFFECTS ON KENOL VALUES
Authors: NUGIEL D. A. , RAPPOPORT Z.
Published: May 2016

Während die Addition von Me ‐ MgBr (IIa) an Dimesitylketen (I) zu (IVa) problemlos erfolgt (70% Ausb.), muß bei der Addition von Et ‐ MgBr (IIb) LiClO4 zugesetzt werden, wobei (IVb) und (IVe) (je 50%) erhalten werden.
ChemInform Abstract: ELECTROCHEMICAL OXIDATION OF AROMATIC ETHERS. PART 10. REGIOSELECTIVITY IN THE ARYL‐ARYL COUPLING REACTIONS OF SOME 4‐BENZYLISOCHROMAN‐3‐ONES AND BENZYL‐1,2,3,4‐TETRAHYDROISOQUINOLINES
Authors: MAJEED A. J. , PATEL P. J. , SAINSBURY M.
Published: May 2016

Aryl Coupling Reactions of Some 4‐Benzy isochroman‐3‐ones und Beuzyll,2,3,4‐tetrahydroisoquinolines.
ChemInform Abstract: AROMATIC NUCLEOPHILIC SUBSTITUTION UNDER SOLID‐LIQUID PHASE‐TRANSFER CATALYTIC CONDITIONS: SYNTHESIS OF ALKYL ARYL THIOETHERS
Authors: SINGH P. , BATRA M. S. , SINGH H.
Published: May 2016

Die 11iioiminiumsalze(Ia)‐(lc) und (IIa)‐(IIc) reagieren mit einer äquimolaren Menge der Arylhalogenide (III) unter Amideliminierung zu den Arylthioethern (IV).
ChemInform Abstract: SYNTHESIS, THERMOLYSIS, AND PHOTOLYSIS OF THE AZOALKANE 4,5‐DIAZATRICYCLO(4.3.03,7)NONA‐4,8‐DIENE: DENITROGENATION VS. AZIRANE FORMATION
Authors: ADAM W. , HILL K.
Published: May 2016

Die nach Schema dargestellte Titelverbindung (IV) zerfällt bei Vakuum‐Blitzthermolyse nur zu 5% zu den Vinylcyclopentadienen (V) und (VI), dagegen entsteht zu etwa 95% das Retro‐Diels‐Alder‐Produkt (Z)‐(VII), das sich unter den Reaktionsbedingungen teilweise weiter zu (E)‐(VII) und Ringschluß zu (VIII) umlagert.
ChemInform Abstract: An Efficient One‐Step Synthesis of 2‐Hydroxy‐2,2,6‐trimethylcyclohexanone.
Authors: RAGOUSSIS N. , ARGYRIADIS N. , NAMOS P.
Published: May 2016

Die Oxidation von β‐Cyclocitral (Ia) bzw. β‐Ionon (Ib) mit wäßriger Kaliumpermanganatlösung führt zum Hydroxycyclohexanon (II).
ChemInform Abstract: COPPER(I)‐ASSISTED SYNTHESIS OF ARYL 2,2,2‐TRIFLUOROETHYL ETHERS
Authors: SUZUKI H. , MATUOKA T. , OHTSUKA I. , OSUKA A.
Published: May 2016

Die Aryliodide (I) lassen sich mit Natrium‐P.,2,2‐trifluorethoxid unter Kupfer(I)‐iodid‐Katalyse in die Aryl‐trifluorethylether (III) überführen.
ChemInform Abstract: A Simple Unusual One‐Step Conversion of Aromatic Aldehydes into Nitriles.
Authors: KARMARKAR S. N. , KELLAR S. L. , WADIA M. S.
Published: May 2016

Die aromatischen Aldehyde (I) werden beim Erhitzen mit Nitroethan (II) in Essigsäure in Gegenwart von Natriumacetat in hohen Ausbeuten in die Nitrile ( III ) übergeführt, während die Umsetzung von aliphatischen Aldehyden wie (IV) und Zimtaldehyd (VI) zu den Nitrilen (V) bzw. (VII) in deutlich geringerer Ausbeute verläuft.
ChemInform Abstract: SYNTHESIS AND PROPERTIES OF P‐HYDROXYACETOPHENONE DERIVATIVES
Authors: KOVAC S. , RAPIC V. , LACAN M. , REINER E.
Published: May 2016

(Ia) wird in die von dem Acetylcholinesterase‐Hemmstoff (IIIb) abgeleiteten Carbamate (IIIa) und (IV) übergeführt.
ChemInform Abstract: THE REACTION OF 1‐SUBSTITUTED THIOUREAS WITH β‐HALOACYL HALIDES IN A TWO‐PHASE SYSTEM
Authors: OKAWARA T. , NAKAYAMA K. , YAMASAKI T. , FURUKAWA M.
Published: May 2016

Durch Umsetzung der Thioharnstoffe (I) mit den Säurechloriden (II) unter Phasentransferbedingungen gelingt es, die β‐Lactame (III) als Hauptprodukte zu synthetisieren.
ChemInform Abstract: PREPARATION OF MONOACETALS OF β‐DICARBONYL COMPOUNDS
Authors: HUET F.
Published: May 2016

β‐Tetralon (I) wird durch Vilsmeier‐Reaktion in die Formylverbindung (II) und mit Natrium‐2‐hydroxyethoxid weiter in das Dioxolan (III) übergefuhrt.
ChemInform Abstract: HYDROACRIDINES AND RELATED COMPOUNDS. 23. DERIVATIVES OF CAPROLACTAM AND HYDROCOUMARINS FROM 4A,10A‐EPIDIOXYPERHYDROACRIDINES
Authors: SHUMAKOV S. A. , KAMINSKII V. A. , TILICHENKO M. N.
Published: May 2016

Die durch Umsetzung von Decahydroacridinen mit Wasserstoffperoxid leicht zugänglichen Epidioxyperhydroacridine (I) liefern bei der Thermolyse in siedendem Xylol Oxocyclohexylhexahydroazepinone (II), aus denen durch Reduktion und Hydrolyse Hydrocumarine (III) und (V) erhalten werden.
ChemInform Abstract: REACTION OF TRICHLOROACETONITRILE AND PHENYL CYANATE WITH YLIDENE NITRILES
Authors: GEWALD K. , HAIN U. , GRUNER M.
Published: May 2016

Die Titelreaktien zwischen den Nitrilen (II), (X) und (XVI) und den Verbindungen (I), hauptsächlich (Ia) und (Ib), ergibt die Produkte (III), (XI) und (XVII).
ChemInform Abstract: A CONVENIENT SYNTHESIS OF BENZO(C)(2,6)NAPHTHYRIDINES
Authors: RAJAMANICKAM P. , SHANMUGAM P.
Published: May 2016

Die N‐(3‐ButenoyD‐isatine (I) werden über die Chinoloncarbonsäuren (II) in die Pyrano‐chinolone (III) und weiter in die 5‐Chlor‐pyrano‐chinoline (IV) übergeführt.
ChemInform Abstract: STUDY OF INTRAMOLECULAR CYCLIZATION OF 3‐(ARYLAZO)‐2‐INDOLYLACETIC ACID ESTERS
Authors: TROFIMOV F. A. , GARNOVA V. I. , TSYSHKOVA N. G.
Published: May 2016

Die aus den Indolylessigsäureestern (I) durch Kupplung mit Diazonium‐ Salzen (II) gebildeten Arylazoindole (III) ergeben bei der Reduktion mit Zink und Essigsäure das Acetylaminoindol (IV).
ChemInform Abstract: HETEROADAMANTANES AND THEIR DERIVATIVES. 3. SYNTHESIS OF 5‐(METHOXYCARBONYL)‐6‐HYDROXY‐1,3‐DIAZAADAMANTANE
Authors: KUZNETSOV A. I. , BOIKO I. P. , SOKOLOVA T. D. , BASARGIN E. B. , UNKOVSKII B. V.
Published: May 2016

Der 4‐Phenylthio‐3‐oxobuttersäuremethylester (I) reagiert mit Ammoniumacetat, Ammoniumcarbonat und Paraformaldehßtd zu dem Phenylthiodiazaadamantancarbonsäureester (II).
ChemInform Abstract: SYNTHESIS AND PROPERTIES OF 5H‐4‐OXOPYRIMIDO(5,4‐B)‐ AND 1H,5H‐2,4‐DIOXOPYRIMIDO(5,4‐B)INDOLES
Authors: SIMAKOV S. V. , VELEZHEVA V. S. , DVORKIN V. V. , SUVOROV N. N.
Published: May 2016

Aus den Indolylamidinen (I) werden durch Cyclisierung mit primären Aminen und Hydrazinen die Oxopyrimidoindole (II) hergestellt und diese weiter über die Chloride (III) in verschiedene Derivate umgewandelt.
ChemInform Abstract: N‐Alkylation of Pyrimidine and Purine Derivatives (Uracils, Xanthines, Adenine) Using Solid/Liquid Phase‐Transfer Catalysis without Solvent.
Authors: BRAM G. , DECODTS G. , BENSAID Y. , FARNOUX C. C. , GALONS H. , MIOCQUE M.
Published: May 2016

Die Alkylierung von Uracilen (I), Xanthinen (IV) und (VI), sowie von Adenin (VIII) in Gegenwart von Kaliumhydroxid und Phasen‐Transfer‐Katalysatoren wie Tetrabutylammoniumbromid oder Aliquat 336 führt in guten Ausbeuten zu den N‐alkylierten Produkten.
ChemInform Abstract: CYCLIZATIONS OF N‐ALKYLAZINIUM CATIONS WITH BIFUNCTIONAL NUCLEOPHILES. 16. Σ‐ADDUCTS OF QUINOXALINIUM SALTS WITH AMINES, ALCOHOLS, AND ENOLATES AND THEIR PART IN CYCLIZATIONS WITH β‐DICARBONYL COMPOUNDS
Authors: CHARUSHIN V. N. , PONIZOVSKII M. G. , CHUPAKHIN O. N. , SIDOROV E. O. , SOSONKIN I. M.
Published: May 2016

N‐Methylchinoxaliniumiodid (I) reagiert mit Nucleophilen unter Bildung von Mono‐ und Bis‐Addukten (II) und (III).
ChemInform Abstract: Herstellung von 4‐Cyanomethylen‐1,3‐benzoxazin‐Derivaten aus 6,6′‐(1,2,4‐Dithiazolidin‐3,5‐yliden)‐bis‐2,4‐cyclohexadien‐1‐onen und substituierten Acetonitrilen.
Authors: BRIEL D. , LEISTNER S. , WAGNER G.
Published: May 2016

Die Umsetzung der Dithiazolidin‐Derivate (I) mit aktivierten Methylenverbindungen(II) in Gegenwart einer Base führt unter Schwefel‐ und Schwefelwasserstoff‐Eliminierung zu den Benzoxazin‐Derivaten (III).
ChemInform Abstract: THE SYNTHESIS OF SULFUROUS DIAMIDE HETEROCYCLES THROUGH THE CYCLOADDITION REACTION OF N‐SULFINYLANILINES WITH BENZALANILINES
Authors: ZOLLER U. , RONA P.
Published: May 2016

Die N‐Sul?nylaniline (I) reagieren mit den Benzalanilinen (II) in einer Cycloadditionsreaktion zu den cyclischen Schwefligsäurediamiden (III).
ChemInform Abstract: OXIDATION OF N‐DECAMETHYLTETRASILANE WITH PEROXYBENZOIC ACID
Authors: RAZUVAEV G. A. , SEMENOV V. V. , BREVNOVA T. N. , KORNEV A. N.
Published: May 2016

Die stufenweise Oxidation des Tetrasilans (I) mit Perbenzoesäure (II) wird untersucht.
ChemInform Abstract: REACTION OF METHYLTRIS(ETHYLTHIO)SILANE WITH 5,5‐DIMETHYL‐2‐ETHOXY‐1,3‐DIOXANE
Authors: LARIONOV V. I. , MUSAVIROV R. S. , KANTOR E. A. , REKHMANKULOV D. L.
Published: May 2016

Der cyclische Orthoester (I) reagiert mit dem Silan (II) zum 1,3‐Dioxa‐2‐ sila‐cyclohexan (III) und dem Orthothioameisensäureester (IV).
ChemInform Abstract: Organo‐silazane mit Phenylethylresten am Siliciumatom und ihre hydrolytische Beständigkeit.
Authors: BUZIASHVILI V. I. , TSKHOVREBASHVILI V. S. , KHANANASHVILI L. M. , ZHINKIN D. YA. , MOLCHANOV B. V. , NIKITIN V. S.
Published: May 2016

Die Ammonolyse des Dichlorsilans (I) in Toluollösung liefert ein Gemisch der Silazane (II)‐(IV).
ChemInform Abstract: Synthesis and Reactions of Mixed Halide Dialkyldithiophosphate Derivatives of Bismuth(III).
Authors: CHAUHAN H. P. S. , SRIVASTAVA G. , MEHROTRA R. C.
Published: May 2016

Dialkyldithiophosphate (I) liefern mit BiCl3 in Abhängigkeit vom Molverhältnis die Wismutdithiophosphate (II)‐(IV).