bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge, Attitude, and Practices of Caregivers in the Management of Asthmatic and Non-asthmatic Children: A Community-based Study
Authors: Shaheen Majd , Nishat Syed Muhammad Hayyan , Tanweer Ammar Shahid , Alshamsi Bashayer , Tanweer Ariba Shahid , Nishat Aroob , Jhancy Malay , Khan Karuna
Published: February 2025

Background:

Bronchial asthma, a chronic inflammatory condition, poses significant health challenges for children. Proper management of childhood asthma
requires the knowledge, attitudes, and practices (KAP) of the caregivers. This study assesses the KAP of caregivers in the management of
asthmatic and non-asthmatic children in the UAE.

Methods:

A cross-sectional study was conducted in Ras Al Khaimah over four months, involving 182 children aged 6-16 years. Data were collected through
a pre-validated KAP questionnaire distributed to caregivers of asthmatic and non-asthmatic children across schools, parks, and private clinics.
Descriptive statistics were used to analyze the responses.

Results:

Among caregivers of asthmatic children, 77.1% demonstrated adequate knowledge, while 45.83% held a positive attitude towards asthma. In
contrast, caregivers of non-asthmatic children had lower knowledge (37%) and attitudes (26.88%). Lack of adequate knowledge led to poor asthma
management practices, with only 75% of caregivers conducting regular follow-ups. Better caregiver knowledge was associated with improved
asthma control, while misconceptions and negative attitudes led to suboptimal care.

Conclusion:

Significant gaps in caregiver KAP were identified, with a need for targeted educational programs to enhance asthma management. Improving
caregiver understanding and attitudes through regular physician visits and educational initiatives is crucial for optimizing asthma outcomes in
children.
Cyclin Dependent Kinases in Antiviral Drug Discovery
Authors: Tarasova Olga , de Azevedo Junior Walter Filgueira
Published: February 2025

Cyclin-dependent kinases that are responsible for cell cycle control, have
been studied for over 30 years as therapeutic targets for the treatment of cancer and inflammation.
In the past twenty years, their activities in various viral infections have
been investigated in the search of novel therapeutic strategies in the treatment of viral infections.
The interest in evaluating the antiviral activity of cyclin-dependent kinase inhibitors
is closely linked to their role as host factors in viral replication. Due to the development
of viral resistance, the strategies directed toward the targeting host machinery
are still under investigation. This review is dedicated to the analysis of the molecular
mechanisms of viral infection control by cyclin-dependent kinases that may reveal the
potential mechanisms of action for their inhibitors and regulators as antiviral agents. We
also consider recent efforts and achievements in the development of potential antiviral
agents based on the cyclin-dependent kinase inhibitors and regulators, including their effects
on various viruses, side effects, and toxicities.
In vitro Antibiofilm Activity-directed In silico Identification of Natural Products Targeting Bacterial Biofilm Regulators SarA and LasR
Authors: Shilpi Jamil A. , Sarker Dipto Kumer , Seidel Veronique , Ali Mohammad Tuhin , Uddin Shaikh Jamal , Basak Ananya , Chakraborty Shaown , Khairuzzaman M , Nahar Akhlak Un , Salam Fayad Bin Abdus
Published: February 2025

Background:

Antibiofilm agents serve as an essential tool in the fight against antibiotic
resistance, and natural products provide a promising source for potential drug leads.

Objective:

This study investigates the activity of twenty Bangladeshi medicinal plants against
Staphylococcus aureus and Pseudomonas aeruginosa biofilms and predicts the interactions of
selected phytochemicals from five of the best performing plants with the active sites of transcriptional
regulatory proteins SarA of S. aureus and LasR of P. aeruginosa.

Methods:

The plant extracts were tested by microtiter plate-based assay against S. aureus and P.
aeruginosa biofilms. Molecular docking and molecular dynamics simulation (MD) were conducted
using PyRx and GROMACS, respectively.

Results:

The best activity was identified for Cassia fistula and Ananas comosus, showing ≥ 75% inhibition of biofilm formation. ent-Epicatechin-(4α→8)-epiafzelechin (EEE) of C. fistula, cyanidin-3,3',5-tri-O-β-D-glucopyranoside (CTG) of A. comosus, and 7-O-(4-hydroxy-Ecinnamoyl)- spinoside of A. spinosus showed the best predictive binding affinity (-7.6, -7.6 and - 7.7 kcal/mol, respectively) for SarA. EEE was the only ligand to exhibit a stable ligand-protein complex with SarA in the MD simulation of 200 ns (binding energy of MMPBSA analysis - 39.899 kJ/mol). Chrysophanol, epicatechin and physcion, of C. fistula (-10.5, -10.5, and -11.0 kcal/mol, respectively) and auraptene of F. limonia (-10.8 kcal/mol) showed the best predictive binding affinity for LasR. Epicatechin showed the most stable ligand-protein complex with LasR (binding energy of MMPBSA analysis -63.717 kJ/mol)

Conclusion:

Epicatechin and its derivative EEE could be used as scaffolds for the development
of new antibiofilm agents against P. aeruginosa and S. aureus, respectively.
Design and Characterization of Antibacterial Peptide Nanofibrils as Components of Composites for Biomaterial Applications
Authors: Sawicka Justyna , Bollin Piotr , Sylla Anna , Panasiuk Mirosława , Wilkowska Michalina , Ciołek Lidia , Leśniewski Mateusz , Konopka Aleksandra , Struniawski Karol , Całka-Kuc Gabriela , Liwo Adam , Hańczyc Piotr , Kozak Maciej , Gromadzka Beata , Biernat Monika , Rodziewicz-Motowidło Sylwia
Published: February 2025

Purpose:

The purpose of this study was to design and synthesize the ug46 peptide, incorporate
its fibrils into composite materials, and evaluate its structural and antimicrobial properties.
Another objective was to utilize spectroscopy and molecular simulation, enhanced by Machine
Vision methods, to monitor the aggregation process of the ug46 peptide and assess its potential
as a scaffold for an antimicrobial peptide.

Method:

The structural analysis of the ug46 peptide reveals its dynamic conformational changes.
Initially, the peptide exhibits a disordered structure with minimal α-helix content, but as incubation
progresses, it aggregates into fibrils rich in β-sheets. This transformation was validated by CD
and ThT assays, which showed decreased molar ellipticity and an increase in ThT fluorescence.

Results:

Laser-induced fluorescence and molecular dynamics simulations further revealed the transition
from a compact native state to extended “worm-like” filament structures, influenced by peptide
concentration and temperature. TEM and AFM confirmed these changes, showing the evolution
of protofibrils into mature fibrils with characteristic twists. When incorporated into chitosan-
bioglass composites, these fibrils significantly enhanced antimicrobial activity against pathogens
such as Staphylococcus aureus and Pseudomonas aeruginosa.

Conclusion:

Overall, ug46 peptide fibrils show promise as a multifunctional scaffold with structural
and antimicrobial benefits in composite biomaterials.
The Modulatory Effects of Anesthetics and Analgesics on Neurophysiological Monitoring and Underlying Mechanisms
Authors: Leng Yu , Teng Yi , Liu Jin , Zou Xian , Ou Mengchan , Zhu Tao , Liang Peng , Zhou Cheng
Published: February 2025

Intraoperative Neurophysiological Monitoring (IONM) is an indispensable surgical
tool that offers invaluable insights into neurological function across a spectrum of anatomical
areas. By comprehensively assessing the integrity of the brain, brainstem, spinal cord, cranial
nerves, and peripheral nerves, IONM plays a pivotal role in guiding surgical decision-making
and optimizing patient outcomes, particularly in the context of high-risk procedures. Intraoperative
drugs, especially anesthetics and/or analgesics, differentially modulate neurophysiological
monitoring, which remarkably affects the application of neurophysiological monitoring under
specific conditions and indicates the neurobiological mechanisms of anesthetics/analgesics. This
review will describe various neurophysiological modalities utilized in intraoperative procedures,
each employing a wide variety of physiological principles; summarize the modulatory effects of
anesthetics/analgesics on these neurophysiological monitoring parameters; and elucidate their
underlying mechanisms, with a particular emphasis on evoked potentials. Insights gleaned from
this review can inform strategies of anesthesia management for surgeries that require IONM and
guide future investigations on the mechanisms of anesthesia/analgesia.
Fasting the Stem Cells to Boost their Metabolic Functions
Authors: França Pedro Henrique Maglio , Degasperi Giovanna Rosa
Published: February 2025

Tissue homeostasis and regeneration depend on differentiated stem cells into specialized
cell types. Dietary interventions, such as caloric restriction, are critical regulators of stem cell functions
by altering their metabolism. This review discusses recent studies illustrating how diet interventions
impact stem cell function. We summarize molecular targets and physiological effects of different
types of caloric restriction and ketogenic mimicking diets in stem cells from bone marrow, muscle,
and intestine. Furthermore, we highlight the nutrient-sensing pathway target of stem cells during
caloric restriction. Understanding how nutrient signaling controls stem cell fate decisions is important
to developing dietary interventions to improve the clinical application of stem cells.
Dihydromyricetin Improves Myocardial Functioning by Influencing Autophagy Through SNHG17/Mir-34a/SIDT2 Axis
Authors: Xiao Hai , Xiao Yan , Zeng Xueliang , Xie Huihui , Wang Ziyao , Guo Yu
Published: February 2025

Background:

Diabetic cardiomyopathy [DCM] is a common and severe complication of Diabetes Mellitus [DM]. Dihydromyricetin [DHM] is a flavonoid
compound with potential cardioprotective effects, but the mechanism of DHM in diabetes-induced myocardial damage and autophagy is not fully
understood.

Objective:

The objective of this study is to evaluate the effects of DHM on cardiac function and pathological features of DCM, with a particular focus on its
impact on the SNHG17/miR-34a/SIDT2 pathway.

Methods:

In vivo experiments: After constructing the DM mice model, it was treated with different doses of DHM. Masson's staining and collagen
deposition/fibrosis markers were used to evaluate the effect of DHM on cardiac fibrosis in DM mice. In vitro experiments: 3-[4,5-
dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide [MTT] assay and flow cytometry were used to determine the influence of DHM on cell
viability and apoptosis, respectively, in high glucose-induced HL-1 cells. ELISA was used to detect levels of cardiac enzyme and inflammationrelated
factors, while Western blot analyzed the levels of AMPK/mTOR and autophagy-related proteins.

Results:

DHM significantly improved cardiac function in DM and reduced Renin-angiotensin-aldosterone system markers, alongside decreasing markers of
cardiomyocyte damage. DHM mitigated myocardial fibrosis, inflammatory marker levels, and autophagy dysregulation while upregulating
lncRNA SNHG17 expression. Mechanistically, DHM acted through the SNHG17/miR-34a/SID1 transmembrane family member 2 [SIDT2] axis,
reducing miR-34a expression and restoring SIDT2-mediated autophagy balance, ultimately alleviating apoptosis, inflammation, and fibrosis in
diabetic cardiac tissue and high-glucose-induced HL-1 cells.

Conclusion:

DHM improves cardiac function and mitigates DCM progression by targeting the SNHG17/miR-34a/SIDT2 regulatory axis, thereby reducing
inflammation, fibrosis, and autophagy dysregulation. These findings provide mechanistic insights into DHM’s cardioprotective effects, supporting
its potential as a therapeutic agent for DCM.
Exploring the Immune-Related Molecular Mechanisms Underlying the Comorbidity of Temporal Lobe Epilepsy and Major Depressive Disorder through Integrated Data Set Analysis
Authors: Yan Shi , Han Zhibin , Wang Tianyu , Wang Aowen , Liu Feng , Yu Shengkun , Xu Lin , Shen Hong , Liu Li , Lin Zhiguo , Na Meng
Published: February 2025

Background:

Temporal lobe epilepsy (TLE) and major depressive disorder (MDD) are prevalent and complex neurological disorders that affect individuals
globally. Clinical and epidemiological studies indicate a significant comorbidity between TLE and MDD; however, the shared molecular
mechanisms underlying this relationship remain unclear. This study aims to explore the common key genes associated with TLE and MDD through
a systematic analysis of gene expression profiles, elucidate their underlying molecular pathological mechanisms, and evaluate the potential
applications of these genes in diagnostic and therapeutic contexts.

Methods:

Brain tissue gene expression data for TLE and MDD were obtained from the GEO database. Differentially expressed genes (DEGs), weighted gene
co-expression network analysis (WGCNA), functional enrichment, and protein-protein interaction (PPI) network construction were performed to
identify shared gene modules. LASSO and random forest (RF) machine learning models were used to select diagnostic candidate genes, validated
through ROC curve analysis. Immune infiltration analysis explored the immune involvement of key genes, while single-cell sequencing confirmed
gene expression across cell types. Potential therapeutic drugs were identified using a drug database.

Results:

A total of 372 DEGs were identified as either up- or down-regulated between TLE and MDD, with WGCNA revealing nine shared gene modules.
Seven hub genes, including HTR7 and CDHR2, demonstrated strong ROC performance. Immune infiltration analysis revealed changes in immune
cell populations linked to key genes, confirmed by single-cell sequencing. Upadacitinib was identified as a potential therapeutic drug targeting
these genes.

Conclusion:

This study identified shared gene expression profiles between TLE and MDD, emphasizing immune pathway-related molecular mechanisms.
Immune infiltration analysis and single-cell sequencing underscored the significance of immune regulation in their comorbidity, while drug
prediction highlights candidates for precision medicine, establishing a foundation for future research and therapeutic strategies.
Chemical Composition, Antioxidant Activities, and Hemolytic Properties of Xanthium italicum Essential Oil from Algeria
Authors: Bendiabdallah Amal , Ayachi Hicham , Fellahi Manel , Dib Mohammed El Amine , Muselli Alain
Published: February 2025

Background:

Essential oils are widely recognized for their antioxidant properties, including
their ability to neutralize free radicals and protect cells from oxidative stress, a key factor in
cell death associated with neurodegenerative diseases.

Objective:

The aim of this study was to analyze the chemical composition of essential oil extracted
from the leaves and flowers of Xanthium italicum and to evaluate its antioxidant activity using the
DPPH test and the Ferric Antioxidant Power Reduction Test (FRAP), as well as its hemolytic properties.

Methods:

Leaf and fruit chemical composition was determined by gas chromatography (GC) and
gas chromatography coupled with mass spectrometry (GC-MS). Antioxidant properties were evaluated
using DPPH and FRAP methods. A suspension of human blood erythrocytes was used to determine
the hemolytic effect of essential oils.

Results:

Thirty-five compounds were identified in the essential oil extracted from the leaves of
Xanthium italicum. The main compounds were limonene (41.5%) and germacrene D (14.2%). For
fruit essential oil, twenty-five compounds were identified, with α-bisabolol (62.2%), α-humulene
(8.1%), and limonene (5.2%) as the main constituents. In-vitro antioxidant activity tests showed that
the essential oil of Xanthium italicum fruits is a powerful antioxidant (0.038 mg/mL), surpassing
even ascorbic acid (0.048 mg/mL). Human erythrocyte toxicity tests showed that the essential oil of
Xanthium italicum leaves and fruits have a relatively low hemolytic effect, with hemolysis rates of
15.3% and 8.1%, respectively, even at high concentrations of 1000 μg/mL.

Conclusion:

The essential oils of Xanthium italicum show a strong antioxidant activity, especially
in fruits, and a low hemolytic effect on human erythrocytes. This could be a safe and effective natural
antioxidant.
Research Progress on Damage and Protection of Key Friction Pairs in Axial Piston Pump
Authors: LI Jianying , Zha Yongyuan , Yang Hailong , Gao Haoyang
Published: February 2025

Background:

Axial piston pumps represent one of the most core and technically challenging
components in hydraulic systems. They are widely used in practical engineering fields
such as hydraulic transmission and control. This article first outlines the development history of
piston pumps and then provides a comprehensive analysis of the research progress on the friction
characteristics and surface modification technologies of key friction pairs in axial piston pumps.

Objective:

This article aims to summarize the friction wear and oil film characteristics of key friction
pairs in axial piston pumps, analyze and elaborate the research progress in improving the
tribological performance of friction pair surfaces through methods such as surface texturing and
surface coating, and provide theoretical support for the damage and protection of axial piston
pumps.

Method:

The present study was conducted by organizing and analyzing research literature from
both domestic and international scholars. The objective was to explore the lubrication and friction
wear properties of key friction pairs, as well as the application of surface texturing, surface coating,
and other technologies in improving the tribological performance of friction pair surfaces.

Results:

A review of pertinent literature has revealed that surface texturing and surface coating
can effectively reduce the friction coefficient of friction pairs, enhance lubrication performance,
and thereby extend the service life of axial piston pumps. Moreover, these methods facilitate the
reduction of wear on the friction pairs and enhance their overall performance.

Conclusion:

This article presents a summary of the research progress on friction, wear, and oil
film characteristics of key friction pairs in axial piston pumps. It also analyzes the role of technologies
such as surface texturing and surface coating in improving the tribological properties of the
friction pair surfaces. Furthermore, it provides a prospective outlook on future developments.
Molecular Genetic Research of GSTM, GSTT and VDR genes
Authors: Aib Nadiia , Lukianenko Nataliia , Chaikovska Hanna , Volosianko Andrii
Published: February 2025

According to the “threshold” model of multifactorial diseases, genetic and epigenetic factors determine each person's predisposition to developing a disease. If this total predisposition exceeds a certain threshold, the disease develops.
The aim of study to investigate the frequency of polymorphic loci TaqI and Apa I of the VDR-3 gene and deletion loci of the genes GSTM1 0 and GSTT1 0 (glutathione-S-transferases) in the genotype of children with dysmetabolic nephropathy.
 Materials and methods. A molecular genetic study of the Taq I polymorphic locus was conducted in 55 children with different severity of dysmetabolic nephropathy: 35 children with complicated dysmetabolic nephropathy and 20 children with uncomplicated DN; the results were compared with the data of 44 healthy children.
Results. We have established an association of dysmetabolic nephropathy with the presence of deletion alleles of GSTM1 0/0 and GSTT1 0/0 in the child's genotype, a significant association of the frequency of simultaneous carriage of deletion alleles GSTT1 0/0+GSTM1 0/0 with a more severe course of DN in children. The ability of the products of these genes to provide cellular resistance to lipid peroxidation free radicals and prevent damage to the HDC was investigated, and it was concluded that the null alleles of GSTM1 0/0 GSTT1 0/0 and, especially, their combination GSTT1 0/0+GSTM1 0/0 may be modifier genes in the pathogenesis of dysmetabolic nephropathy in children. 
Conclusions. Molecular genetic analysis of polymorphic variants of the VDR3 gene showed a difference in the frequency of VDR3 alleles and genotypes between children with dysmetabolic nephropathy and healthy children. This confirms that allelic variance in the VDR3 gene may be a risk factor for developing dysmetabolic nephropathy, and the gene itself may be considered a candidate gene in the pathogenesis of multifactorial inheritance of dysmetabolic nephropathy. The results obtained may further form the basis of screening tests for diagnosing dysmetabolic nephropathy in children.
Risk of Bradycardia and Syncope Associated with the Use of Cholinesterase Inhibitors in Patients with Alzheimer's Disease and Related Dementias: A Systematic Review and Meta-Analysis (Preprint)
Authors: Okeke Chijioke , Slade Tenia , Tucker Sarah Beth , Whitworth Olivia , Rane Amey , Love Bryan , Karaye Ibraheem , Alsahali Saud , Maleki Nasim , Alotaibi Nawaf , Thornton Douglas , Yunusa Ismaeel
Published: February 2025

BACKGROUND

In some cases, cholinesterase inhibitors (ChEIs) can amplify the effect of acetylcholine on vagal stimulation of the heart, which may lead to syncope and bradycardia. Available evidence does not definitively establish this association, and therefore clinicians may be unaware of it.

OBJECTIVE

To systematically review and perform a meta-analysis of the risk of bradycardia and syncope in patients with Alzheimer's Disease and Related Dementias (ADRD) treated with ChEIs.

METHODS

Our data sources were PubMed, EMBASE, Cochrane Library, and reference lists of relevant articles. Databases were searched from inception to June 15, 2024. We included randomized controlled trials and observational studies (cohort and case-control studies). Three reviewers independently extracted data per PRISMA recommendations and assessed the quality of each study with the National Heart, Lung, and Blood Institute quality assessment tools. We used random-effects modeling to estimate pooled relative risks (RRs) and their 95% confidence intervals (CIs). The outcomes examined were bradycardia and syncope.

RESULTS

Twenty-five independent studies (sixteen RCTs, seven cohorts, one case-control, one pragmatic trial; n=258,388) were included in the systematic review and meta-analysis out of the original 310 studies identified. The median reported age in the studies included was 76.3 years (range from 70 to 89.2). In most studies (18 out of 25), more than half of the individuals were female. Additionally, 18 (72%) of the studies included patients with Alzheimer’s disease. The overall absolute risk of bradycardia was 4.63% (95% CI, 1.80-8.55%; 16 studies, n=97,165), and that of syncope was 2.31% (95% CI, 1.18-3.77%; 16 studies, n= 134,162). Use of ChEIs in patients with ADRD was significantly associated with increased risk of bradycardia (RR: 1.23 [95% CI: 1.14-1.33]; 6 studies, n=97,396) and syncope (RR: 1.40 [95% CI: 1.20-1.64]; 9 studies, n=85,169) compared to non-use.

CONCLUSIONS

This systematic review and meta-analysis suggest that patients with ADRD treated with ChEIs have an increased risk of bradycardia and syncope. Therefore, clinicians should consider the risk of bradycardia and syncope against the benefits of ChEIs when treating patients with ADRD.
Concurrent treatment of opioid and tobacco use disorder in a telemedicine clinic: A case report of breaking through barriers (Preprint)
Authors: Michero Darcy , Monico Laura , Pielsticker Peyton , Mooney Larissa J , Glasner Suzette
Published: February 2025

UNSTRUCTURED

There are a myriad of obstacles faced by individuals who take medication for opioid use disorder (MOUD), including high out-of-pocket costs, stigma, logistical challenges associated with traveling to treatment facilities, and negative experiences with treatment providers. The proliferation of illicit fentanyl use and associated overdose risk underscores the urgent need to broaden access to lifesaving pharmacotherapy for opioid use disorder. This case report describes the safe and effective induction of a 32-year-old male onto sublingual buprenorphine in a virtual care setting, with integrated, counselor-facilitated psychosocial treatment delivered via a smartphone application targeting relapse prevention. The virtual care modality enabled this patient to overcome two major treatment barriers: limited access to evidence-based treatment given his residence in a rural area, and heightened overdose risk given his use of fentanyl, a potent synthetic opioid. In addition, we describe tobacco cessation treatment delivered virtually concurrent with OUD care, combining pharmacotherapy and behavioral skills training. Given the disproportionately high rate of co-occurring OUD and tobacco use and associated mortality rates, the effective treatment of these conditions simultaneously in this case advances our knowledge of potentially efficacious treatment approaches for underserved individuals with OUD who present with polysubstance use.

INTERNATIONAL REGISTERED REPORT

RR2-10.1177/20552076241258400
Social Unrest and Distrust
Authors: Pamerdyatmaja Pamerdyatmaja
Published: February 2025

Shadow Play provides an insight into urban studies in Indonesia by showing Yogyakarta as a space of interaction with research on relocation among development discourses. Relocation was often under the unilateral regulatory power of the state (government) in the new order era. Gibbings offers a new perspective in which the relocation of traders is not solely focused on the displacement of a group of people but shows the tug-of-war in drafting agreements after the authoritarian regime's collapse through the 1998 reform agenda. In this book, Gibbings includes two introductory arguments to evoke the reader. First, the study of politics and information control is a subject relation that can change at any time, along with the involvement of stakeholders daily. Second, by focusing on the politics of information, Gibbings exposes the relationship between the state and its citizens, particularly in post-authoritarian situations.
Women’s Motivation in Utilizing Culture for Sustainable Economic Improvement at Desa Pesanggrahan
Authors: Wahyuni Lilik , Utaminingsih Alifiulahtin , Uyun Dhia Al , Riniwati Harsuko , Wike Wike , Setyiawati Eti , Almira Nabila Sella , Arifin Nur Hikmah
Published: February 2025

Women play a crucial role in driving advancements in the local economy in alignment with the Sustainable Development Goals. This research seeks to offer an unbiased understanding of women’s motivational levels, perspectives, and roles in Desa Pesanggrahan, Mojokerto, East Java, contributing to the development of their cultural landscape. This descriptive qualitative study utilized data collected from August to September 2023 through document reviews, interviews, and observations with female members of the Family Welfare Development (Pembinaan Kesejahteraan Keluarga [PKK]) in Desa Pesanggrahan organization in Desa Pesanggrahan. We employed Abraham Maslow's theory on the hierarchy of needs as a base for the analysis of this paper. The result of interviews with the locals, documentation, and observation carried out in the data collection of this research found that women in Desa Pesanggrahan still have low motivation based on Maslow’s theory. This affects their ability to generate innovative ideas and make independent decisions in the development of local culture. Women tend to select men as their leaders, as they often lack the confidence to assume leadership roles in the village. Their role in developing their cultural products in the village is overshadowed by the men of the village.
Meninjau Penerapan Community-Based Tourism di Desa Wisata Karangrejo, Borobudur: Stakeholder Mapping Analysis
Authors: Aulia Finda Elfa , Subakti Isroq Adi , Khoirini Iwanda Luthfi , Anggraeni Larissa Dewi , Trisnawati Nadilla , Putri Pratiwi Ayu
Published: February 2025

Karangrejo Tourism Village, Borobudur District, Magelang Regency, Central Java Province applies the concept of Community Based Tourism (CBT) in tourism management by involving various stakeholders in it. However, in its management, not all stakeholders have the same power and interest, as well as the roles they have. Through this study, the mapping of stakeholders and their roles in tourism management in Karangrejo Tourism Village will be further described. This study uses a qualitative method to map stakeholders who play a role in the development and management of Karangrejo Tourism Village using primary and secondary data through interviews, observations, and literature studies. The results of the study show that the implementation of CBT in Karangrejo Tourism Village has a positive impact on the economic, social, cultural, environmental, and political dimensions. Also the differences in power and interest and roles between stakeholders, including local communities, government apparatus (village and regional), the private sector, and international organizations. The conclusion of the study highlights the success of the implementation of CBT and the importance of mapping the stakeholders involved to avoid overlapping roles and increase collaboration between them.
Copysites: Persepsi Wisatawan Mengenai Reproduksi Simulakra di Petite France
Authors: Rajagukguk Ivana Chrisnauli Zevania
Published: February 2025

This study discusses simulacra reproduction at copysites, Petite France in Gapyeong, South Korea. Simulacra means a copy of a non-existent reality. Petite France was chosen because it is the only theme park with a French countryside vibe and combines pop art from The Little Prince, a french famous literature. France, the country that is most romanticized by tourists, making Korean and foreign tourists both those who have been to France and those who have not been interested in visiting Petite France to see how South Korea visualizes France. The theoretical basis for simulacra in this study is based on the research of Gravari-Barbas (2019) and Fangnan (2017). The method used in this study was semi-structured interviews with fourteen Korean tourists and seven foreign tourists visiting Petite France. The results of the study show that tourists do not care about the historical origins and cultural authenticity of the attractions and architecture in Petite France. It is known that their reason for visiting is for fun, entertainment, and to get a unique and different yet familiar experience through their lives. Petite France as copysites is the result of simulacra because it doesn't really imitate a real place in France, but creates a new French village in Korea and unify The Little Prince literature to add tourist’s experiences.
Social Impacts of Ecotourism Development in Kalibiru
Authors: Nurasih Wiji , Suprianto Bibi
Published: February 2025

Kulon Progo possesses the potential of natural beauty in the form of forests and hills. With the emergence of awareness about ecotourism potential, significant social transformations have occurred, particularly for the community in Kalibiru over the past decade. The initiation of ecotourism in Kalibiru has led to a surge in socio-economic changes among the local population. This paper aims to present the social transformation that has taken place in Kalibiru in relation to changes in forest status and the operation of ecotourism. The research is qualitative and employs participatory observation, in-depth interviews, and documentary studies in data collection. The obtained data will be analyzed from the perspective of social change based on conflicts. From this research, it can be concluded that tourism grows due to conflicts arising from detrimental changes in forest status policies affecting the local community. The existence of Kalibiru ecotourism has transformed an agrarian-based community into tourism participants. When the ecotourism sector experiences a downturn, it creates socio-economic changes in the community, requiring them to return to agrarian activities or seek alternative livelihoods.
Analisis Ekowisata di Kawasan Konservasi Perairan Raja Ampat: Daya Dukung dan Evaluasi Wisatawan dari Situs TripAdvisor
Authors: Larasati Sharfina Elda , Aminun Nur Fadhlan
Published: February 2025

Managing natural tourism in the Water Conservation Area (KKP) is challenging as it must adhere to conservation principles while preserving user access rights and visitor experiences. To address this, we conducted a literature review to aid KKP Raja Ampat in developing sustainable ecotourism. Using TripAdvisor reviews, we assessed tourist perceptions, analyzing 35 reviews covering overall satisfaction, environmental aspects, service, and management. Carrying capacity calculations, following the Cifuentes method, were applied in a case study of KKP Dampier Strait and various marine tourism areas in Raja Ampat. Findings reveal the real carrying capacity in KKP Dampier Strait is 8 - 854 visitors daily, while in Raja Ampat marine tourism areas, it ranges from 17 - 1,881 visitors depending on location and activities. The tourism potential can be further developed with suggestions based on carrying capacity calculations. TripAdvisor reviews indicate excellent tourist experiences. Ultimately, these reviews serve as a valuable tool for decision-makers, identifying negative aspects and proposing solutions for effective management.
Evaluasi Penerapan Eco-Label dalam Pengembangan Ekowisata di Desa Wisata Nglanggeran, Yogyakarta
Authors: Husniyah Jihan Fitri , Dewanti Sefila Nesya , Cahyani Siti Nur
Published: February 2025

This research was conducted to analyze the application of eco-labels in the development of ecotourism in the Nglanggeran Tourism Village, due to urgency of eco-labels as an official identity that shows the commitment of an ecotourism destination to certain standards related to aspects of nature conservation, local economic empowerment and cultural preservation local to maximize the quality of sustainable ecotourism management. This research uses a qualitative method based on an in-depth literature review to analyze the implementation of eco-labels in the Nglanggeran Tourism Village. The research results show that ecotourism management in the Nglanggeran Tourism Village has fulfilled most of the ideal criteria for an ecotourism destination, even though it has not received eco-label legitimacy from the relevant official institutions. Therefore, it is necessary to have an official eco-label institution to provide an official label as an ecotourism destination in the Nglanggeran Tourism Village so that it can maximize its management, especially in minimizing negative impacts on the environment.
Are We Doing Enough to Recruit and Retain Nontraditional, Part Time Learners in Our Colleges and Universities?
Authors: Flynn Ellen , Rios Jacqueline
Published: February 2025

The researchers contend that colleges and universities are not providing enough student support services, academic advisement, proper course design and course content to meet the cognitive, social emotional, financial, and work-related needs of nontraditional, part time learners. Even though enrollment for part time learners is projected to increase in the near future, colleges and universities tend to overlook this ever-growing, diverse student population. Suggestions for how to improve support services for the nontraditional, part time learner, recruitment, and retention initiatives, as well as effective teaching-learning experiences to promote academic success for the part time learner are presented and discussed in detail. The implementation of these suggestions should promote the part time learner’s ability to acquire the necessary skills and knowledge to stay relevant in the job market and, at the same time, increase enrollment of this unique student population on our college and university campuses.
A Review on Therapeutic Potential of Dragon Fruit (An Exotic Super Fruit)
Authors: Gawade Sanika
Published: February 2025

Dragon fruit (Hylocereus spp.) is an emerging superfruit in India, gaining popularity in both rural and urban areas
due to its vibrant color, delicious flavor, and exceptional nutritional and therapeutic properties. This fruit thrives in semi-arid
tropical, subtropical, and humid environments. Its rising demand is driven by its rich antioxidant content and numerous health
benefits.
Among the different varieties, red dragon fruit (Hylocereus polyrhizus) is one of the most cultivated and consumed fruits in
Indonesia. It has been found to exhibit significant antibacterial, antifungal, neuroprotective, cardioprotective, and antiplatelet
properties. This comprehensive review highlights the various nutraceutical applications and health advantages of dragon fruit,
along with its biological origin, history, geographic distribution, cultivation, and bioactive compounds present in different parts
of the plant. With its increasing nutritional and commercial significance, dragon fruit is gaining recognition for its medicinal
potential. Its bioactive components, including flavonoids, phenolics, and betalains, contribute to its health-promoting properties.
Additionally, research suggests that dragon fruit may play a role in regulating lipid metabolism and blood glucose levels, making
it a promising candidate for managing chronic conditions such as diabetes and obesity. To further support both health and
economic development, more extensive studies on its phytochemical composition are essential.
Potential and limitations of random Fourier features for dequantizing quantum machine learning
Authors: Sweke Ryan , Recio-Armengol Erik , Jerbi Sofiene , Gil-Fuster Elies , Fuller Bryce , Eisert Jens , Meyer Johannes Jakob
Published: February 2025

Quantum machine learning is arguably one of the most explored applications of near-term quantum devices. Much focus has been put on notions of variational quantum machine learning where parameterized quantum circuits (PQCs) are used as learning models. These PQC models have a rich structure which suggests that they might be amenable to efficient dequantization via random Fourier features (RFF). In this work, we establish necessary and sufficient conditions under which RFF does indeed provide an efficient dequantization of variational quantum machine learning for regression. We build on these insights to make concrete suggestions for PQC architecture design, and to identify structures which are necessary for a regression problem to admit a potential quantum advantage via PQC based optimization.
¿Qué está pasando con la Tasa de Cambio en Colombia?
Authors: Álvarez García Rubén Darío
Published: February 2025

Esta reflexión ofrece una revisión de las características y principales causas del fenómeno de la devaluación acelerada que está afectando la economía colombiana. A partir de la información de la tasa de cambio nominal en Colombia para el período 1991-2022 y para otros cuatro países (Brasil, Chile, México y Perú), en el período 1998-2022 se evidencia que la devaluación que sufren estas economías es un fenómeno estructural (de largo plazo) y no es un fenómeno coyuntural o transitorio (de corto plazo). A pesar de no realizar un ejercicio técnico riguroso para tratar de evidenciar cuáles son las causas del fenómeno de perdida continúa en los últimos treinta y dos años del valor de la moneda local respecto al dólar, se plantean algunas ideas sobre las principales causas y posibles soluciones.
New Approach for Soil Carbon and Nitrogen Assessment through Image Analysis: A Case Study with Oxisols and Inceptisols
Authors: Rinaldi Juliano Tiago , Casanova Dalcimar , Macedo dos Santos Tonial Larissa , Teixeira Marcelo , Silvério Lopes Heitor
Published: February 2025

This paper presents a new method for predicting carbon and nitrogen content in Oxisols and Inceptisols soils using image analysis. The dataset comprises 40 Oxisols images and 51 Inceptisols images collected in southern Brazil. The images were segmented to isolate the soil area, resulting in the extraction of 12,744 windows. A pre-trained EfficientNetV2-S model was fine-tuned for regression, adding five layers at the end. The model was evaluated using RMSE and R² metrics. Two experiments were conducted: one predicting carbon and nitrogen content for each window and another predicting the median values of the windows for each soil sample. The results show that the median-based prediction significantly improved model performance, achieving an R² of 0.7425 for carbon and 0.7774 for nitrogen. This method offers a faster, non-destructive alternative to laboratory analysis for estimating soil carbon and nitrogen content, contributing to sustainable agricultural practices.
Identifying Malignant Skin Diseases Through Deep Learning
Authors: Sávio de Lima Mota Gabriel , Vieira da Silva Matheus , Mari João Fernando , Backes André Ricardo
Published: February 2025

Early and accurate identification of malignant skin diseases is critical to improving treatment outcomes and patient prognosis. Current diagnostic methods heavily rely on visual assessments by medical professionals, followed by biopsies for confirmation. These approaches can be subjective and require significant expertise, while access to specialized care remains limited, particularly in developing regions. Recent advancements in artificial intelligence, specifically deep learning, present an opportunity to improve dermatological diagnostics. This paper explores the application of two deep learning models, ResNet and Vision Transformer (ViT), for the automated detection of malignant skin conditions. Both models were trained on the PAD-UFES-20 dataset, which comprises clinical skin lesion images captured via smartphones. Our findings suggest that these models can offer real-time diagnostic support at reduced costs, with accuracy levels comparable to or exceeding human performance, with the best experiment achieving the F1 score of 79.89% and an accuracy of 80.63%.
Medical Image Classification with Privacy: Centralized and Federated Learning Comparison
Authors: Ferreira Rodrigues Leonardo Gabriel , V. Gomes Barbosa Gleidson , Moreira Rodrigo , Ferreira Rodrigues Moreira Larissa , Backes André Ricardo
Published: February 2025

The use of different techniques in image-based medical diagnostic computing has positively impacted the healthcare industry. Diseases such as colon and lung cancer can be detected using image classification strategies. In this context, Federated Learning (FL) has emerged as an enabling approach to disease detection with security and privacy when handling sensitive patient data. This study aimed to compare the centralized and FL classifications of histopathological images of lung and colon cancer. We compared the performance of FL with that of centralized learning, and the results indicated that FL outperformed centralized approaches in scenarios with heterogeneous datasets. These findings highlight the potential of FL as an alternative to medical image classification, particularly in privacy-sensitive applications.
Construction of Rolled Digital for Newborns Using Image Registration
Authors: Catuzzo de Bona Wesley Augusto , Oliva Jefferson Tales , Puttow Southier Luiz Fernando , Favarim Fabio , Teixeira Marcelo , Casanova Dalcimar
Published: February 2025

This work aimed to reconstruct rolled fingerprint images from multiple flat fingerprints using image registration and composition techniques. The methodology involved selecting high-quality frames through a quality network, the application of preprocessing with remapping, cropping the area of interest, and adjusting colors. In addition to image registration steps, like key point identification, feature matching, and image distortion. Results indicated that while classical image registration had limitations, the composition technique significantly increased the number of features extracted, enhancing fingerprint identification. It was demonstrated that the composition method effectively captures important fingerprint details, offering a potential improvement in newborn biometric identification.
Bulldogs Nose Detection using Deep Learning
Authors: Medeiros Ramos Carvalho Joyce Katiuccia , Neves da Silva Pedro Henrique , Adriana Uhry Sandra , Da Silva Andrade Gustavo , Braziliano de Andrade Gisele , Pistori Hemerson , Loebens Newton
Published: February 2025

An animal nose identification system could allow efficient monitoring of pets, and it can be used in applications such as identifying animal breeds or possible diseases and/or injuries. For that, a bulldog image dataset was build from French bulldogs. To carry out the validation through cross-validation, 10 folds (K-folds) were created. Afterward, five convolutional neural networks (CNN) were trained with our dataset to identify the nose: Faster R-CNN (Region-based CNN), SABL (Side-Aware Boundary Localization), RetinaNet (ResNet50+FPN), VFNet (VarifocalNet), and ATSS (Adaptive Training Sample Selection). Faster R-CNN, SABL, RetinaNet, VFNet and ATSS were used for training in the first phase, while ATSS, Faster R-CNN, ATSS and SABL in the second. The results showed that the ATSS network obtained the highest values of mAP and Accuracy in the first phase. Moreover, SABL network achieved the highest values of mAP50, mAP75, Recall, F-Score and Accuracy at the end of the second phase.
Governos subnacionais e a questão climática:
Authors: Israel de Souza Sarah Gabriela , De Albuquerque Anna Luisa Soares , Magalhães Lissandra Girão
Published: February 2025

O presente artigo busca fazer uma síntese das relações da paradiplomacia, a internacionalização de cidades e estados, com a agenda climática. A partir disso, primeiro, busca-se fazer uma breve conceituação do termo “cooperação descentralizada” e sua presença na agenda climática dos governos locais brasileiros. Em segundo lugar, são apresentadas as atuações do International Council for Local Environmental Initiatives (ICLEI) e do Grupo C40 de Grandes Cidades para a Liderança Climática na promoção de debates que interligam a paradiplomacia e as questões climáticas. Em seguida, busca-se realizar um estudo de caso da criação e atuação da Secretaria do Clima de Niterói (Seclima), sendo a primeira secretaria municipal do Clima no Brasil. Nesta seção, foi utilizado o conceito da Governança Multinível (GMN), a fim de compreender melhor a importância dos entes subnacionais no combate aos problemas globais a nível local. Para a metodologia, foi realizada uma pesquisa nas bases de dados das redes supramencionadas, bem como de agências especializadas em questões climáticas e ambientais das Nações Unidas. Ademais, também realizou-se uma entrevista com Luiz Fernando Guida, secretário da Seclima, com o objetivo de compreender a origem do órgão, bem como seus principais projetos e estratégias no combate aos efeitos da mudança climática. Por meio da análise da atuação da secretaria, conclui-se que para a resolução dos efeitos da questão climática é necessário a atuação dos governos subnacionais, e os impactos positivos na cidade de Niterói evidenciam os ganhos advindos da cooperação descentralizada.
BREVIDADE DO CORPO QUE FALA:
Authors: De Lima Raposo Juliano , Maria Gomes Cachoeira Adrezza , Costa Maia de Vasconcelos Raíra
Published: February 2025

Diante das produções literárias angolanas femininas, algumas escritoras recorreram à literatura para, por meio da memória e da tradição ancestral, apresentar o cenário de outrora pela suas palavras e pelo seu empenho literário, como a poeta Ana Paula Tavares, a qual por meio de duas faces (intimista e coletiva) consegue delinear bem seu projeto poético, em que vemos não somente literatura, mas a exposição das situações adversas as quais vivenciaram. Desse modo, esse artigo objetiva verificar a concisão dentro da produção poética de Ana Paula Tavares, vislumbrando a presença de características únicas que dão subjetividade aos seus textos, por meio de criações imagéticas em relação ao corpo da mulher e a mãe-terra. Além de esboçar brevemente as produções de autoria feminina de Angola: suas características, distinções e aproximações. Para isso, nos fundamentamos nas ideias de Arenas (2019), Candido (1987), Lótman (1978), Padilha (2002; 2007), Paz (1994) e Pound (2006). As análises foram feitas por meio de três poemas selecionados da poesia reunida da autora intitulada Amargos como os frutos (2011), em que observamos a autora em suas nuances do eu-mulher e o eu-social.