bluuebunny/crossref_metadata_2025 huggingface dataset:
Lung cancer in recipients after lung transplant: single-centre experience and literature review
Authors: Lashari Bilal Haider , Vender Robert J , Fleitas-Sosa Derlis Christian , Sinha Tejas , Criner Gerard J
Published: April 2022

Introduction

Lung cancer is a major challenge facing modern medicine. It is the leading cause of cancer-related death in the USA. Little is known of the incidence, prevalence and disease characteristics in lung transplant recipients, a population unique in its vulnerability and exposure to carcinogenic risk factors. We aimed to elaborate these characteristics of lung cancer in our population through a retrospective cohort study.

Methods

We retrospectively reviewed our institution’s 8-year experience with lung transplantation and searched for patients with a post-transplant diagnosis of lung cancer, neoplasia or mass. We focused on patient demographics, indication for transplant, smoking history, stage at diagnosis, location of the tumour, length of time between transplant and diagnosis, the treatment offered and length of time from diagnosis to death or last follow-up. Descriptive statistics and survival analysis standard Kaplan-Meier method was conducted from the date of cancer diagnosis to death from all-cause mortality or last follow-up as of August 2021.

Results

We identified 24 patients with de novo lung cancer postlung transplant in 905 recipients. More patients with an underlying diagnosis of idiopathic pulmonary fibrosis developed lung cancer. Twenty-one patients were diagnosed with non-small cell lung cancer and three had small cell lung cancer. The remaining native lung was involved most in single lung recipients with 17 patients. Patients with a diagnosis of lung cancer had a mean survival of 17.6 months after diagnosis.

Discussion

The incidence rate of lung cancer in our cohort was higher than reported for smokers from the general population in previous studies. In this study, we compare our findings with available literature. We also explore screening strategies, treatment modalities, survival and postulated mechanisms for the development of lung cancer in lung transplant recipients.
The impact of adopting low-molecular-weight heparin in place of aspirin as routine thromboprophylaxis for patients with hip fracture
Authors: Poacher Arwel T , Hoskins Hannah C , Protty Majd B , Pettit Rebecca , Johansen Antony
Published: April 2022

Purpose of the study

In 2010, the National Institute for Health and Care Excellence (NICE) recommended the use of anticoagulants rather than aspirin as pharmacological thromboprophylaxis after hip fracture. We examine the impact of implementing this change in guidance on the clinical incidence of deep vein thrombosis (DVT).

Study design

Demographic, radiographic and clinical data were retrospectively collected for 5039 patients admitted to a single tertiary centre in the UK for hip fracture between 2007 and 2017. We calculated rates of lower-limb DVT and examined the impact of the June 2010 change of departmental policy, from use of aspirin to use of low-molecular-weight heparins (LMWH) in hip fracture patients.

Results

Doppler scans were performed in 400 patients in the 180 days after a hip fracture, and identified 40 ipsilateral and 14 contralateral DVTs (p<0.001). The rate of DVT reduced significantly following the 2010 change in departmental policy from aspirin to LMWH in these patients (1.62% vs 0.83%, p<0.05).

Conclusions

The rate of clinical DVT halved following the change from aspirin to LMWH for pharmacological thromboprophylaxis, but the number needed to treat was 127. A figure of <1% for the incidence of clinical DVT in a unit that routinely uses LMWH monotherapy following hip fracture provides a context for discussions of alternative strategies, and for power calculations for future research. These figures are important to policy makers and to researchers as they will inform the design of the comparative studies on thromboprophylaxis agents for which NICE has called.
Potential role of d-chiro-inositol in reducing oxidative stress in the blood of nonobese women with polycystic ovary syndrome
Authors: Simic Dusan , Nikolic Turnic Tamara , Dimitrijevic Aleksandra , Zivadinovic Aleksandar , Milosevic-Stevanovic Jelena , Djuric Dusan , Zivkovic Vladimir , Jakovljevic Vladimir
Published: April 2022

d- chiro-Inositol (DCI), an isomer of inositol, possesses antioxidative and endothelial protective properties. Possibly due to a deficiency of insulin mediators, polycystic ovary syndrome (PCOS) is often associated with insulin resistance (IR) and hyperinsulinemia, likely responsible for an elevated production of reactive oxygen species. We investigated oxidative-related alterations of inositol in the blood of women with PCOS before and after treatment with DCI. A total of 38 normal-weight PCOS women were investigated before and after DCI administration (500 mg/day for 12 weeks; n = 38) by evaluating serum testosterone, serum androstenedione, fasting serum insulin, fasting serum glucose, and parameters of IR. From the blood, we determined biomarkers of oxidative stress: superoxide anion radicals, hydrogen peroxide, nitric oxide, and the index of lipid peroxidation. The activity of catalase and superoxide dismutase and the reduced glutathione (GSH) content in the hemolysate were also assessed. Data showed that PCOS patients' plasma underwent oxidative stress, as indicated by the higher level of prooxidants and reduced cytosolic GSH content. DCI treatment significantly improved the metabolic parameters. Also, serum values of testosterone were reduced. In conclusion, PCOS patients suffer from a systemic oxidative stress that induces endothelial dysfunction. Treatment with DCI is effective in reducing hormonal, metabolic, and oxidative abnormalities in PCOS patients by improving IR.
Coulomb scattering in the massless Nelson model IV. Atom–electron scattering
Authors: Dybalski Wojciech , Pizzo Alessandro
Published: April 2022

We consider the massless Nelson model with two types of massive particles which we call atoms and electrons. The atoms interact with photons via an infrared regular form-factor and thus they are Wigner-type particles with sharp mass-shells. The electrons have an infrared singular form-factor and thus they are infraparticles accompanied by soft-photon clouds correlated with their velocities. In the weak coupling regime, we construct scattering states of one atom and one electron, and demonstrate their asymptotic clustering into individual particles. The proof relies on the Cook’s argument, clustering estimatesblack, and the non-stationary phase method. The latter technique requires sharp estimates on derivatives of the ground state wave functions of the fiber Hamiltonians of the model, which were proven in the earlier papers of this series. Although we rely on earlier black studies of the atom–atom and electron–photon scattering in the Nelson model, the paper is written in a self-contained manner. A perspective on the open problem of the electron–electron scattering in this model is also given.
Structure, morphology and optical characterization of Sm3+-doped MgGeO3 nanocrystals for warm white light emitting devices
Authors: Song Hongqing , Zhang Min , Cui Ruirui , Huang Weichao , Deng Chaoyong
Published: April 2022

Orange-red emitting Sm[Formula: see text]-doped MgGeO3 phosphors were synthesized by traditional high temperature solid state method. The powders were characterized by using X-ray diffraction (XRD), scanning electron microscope (SEM), energy-dispersive spectrometer (EDS), UV-Vis spectrometer and photoluminescence (PL) spectra. XRD, SEM and EDS analysis results revealed that MGO:Sm phosphor samples were successfully synthesized. and the optimum MGO:0.1% mol Sm[Formula: see text] phosphor exhibited good photoluminescence emission intensity, thermal stability, life time and color purity. The diffuse reflectance spectra give the results of sample absorption, reflectance, transmittance and optical band gap. The larger optical band gap is 5.25 eV and the stronger photoluminescence intensity [Formula: see text] when the doping concentration is 0.1[Formula: see text] mol. The dipole–dipole interaction is the main mechanism of the concentration quenching phenomenon. The thermal activation energy of the sample is 0.176 eV, and the life time of the prepared sample can reach 14.76 [Formula: see text]s, due to the correlated color temperature (CCT) of less than 2000 K, the potential application value in warm white light emitting device.
Entanglement entropy across the lattice-continuum correspondence
Authors: Radičević Đorđe
Published: April 2022

This paper revisits the standard calculations of free field entanglement entropy in light of the newly developed lattice-continuum correspondence. This correspondence prescribes an explicit method to extract an approximately continuum quantum field theory out of a fully regularized lattice theory. This prescription will here be extended to subregion algebras, and it will be shown how entropies of continuum boson and fermion theories can be computed by working purely with lattice quantities. This gives a clear picture of the origin of divergences in entanglement entropy while also presenting a concise and detailed recipe for calculating this important quantity in continuum theories.
Optimization of second-order nonlinear optical susceptibilities in 1D GaN photonic crystal
Authors: Benachour Yassine
Published: April 2022

We report the modeling and optimization of 1D periodic structures for second-order nonlinear effects. We present the work done in modeling to determine the location of the electromagnetic field in periodic structures. This modeling, carried out in a simple one dimension, makes it possible to mastery the properties of these structures and to study the influence of the different physical parameters on these properties. It allowed us to optimize structures for second-order nonlinear effects by focusing on the two essential factors of nonlinear polarization intensity and phase matching. This study, carried out in 1D structures, was extended to 1D planar structures (called 1.5D) used in guided optics and applied to the design of a 1.5D photonic crystal structure made in a Gallium Nitride layer for the second harmonic generation.
On weak stability of shock waves in 2D compressible elastodynamics
Authors: Trakhinin Yuri
Published: April 2022

By using an equivalent form of the uniform Lopatinski condition for 1-shocks, we prove that the stability condition found by the energy method in [A. Morando, Y. Trakhinin and P. Trebeschi, Structural stability of shock waves in 2D compressible elastodynamics, Math. Ann. 378 (2020) 1471–1504] for the rectilinear shock waves in two-dimensional flows of compressible isentropic inviscid elastic materials is not only sufficient but also necessary for uniform stability (implying structural nonlinear stability of corresponding curved shock waves). The key point of our spectral analysis is a delicate study of the transition between uniform and weak stability. Moreover, we prove that the rectilinear shock waves are never violently unstable, i.e. they are always either uniformly or weakly stable.
The Immunostimulant Effects of Isochrysis galbana Supplemented Diet on the Spleen of Red Hybrid Tilapia (Oreochromis spp.) Evaluated by Nuclear Magnetic Resonance Metabolomics
Authors: Bustamam Muhammad Safwan Ahamad , Pantami Hamza Ahmed , Azam Amalina Ahmad , Shaari Khozirah , Min Chong Chou , Ismail Intan Safinar
Published: April 2022

Significant measures at improving aquaculture health have to be taken since disease outbreaks commonly occur in the fast-growing aquaculture industry. This study aimed to determine the immunomodulatory properties of an indigenous Malaysian microalgae species, Isochrysis galbana (IG), on red hybrid tilapia (Oreochromis spp.). Then, the potential biomarkers for immunomodulatory properties were identified through metabolic changes in the spleen using the proton nuclear magnetic resonance (1H NMR) metabolomics approach. IG was cultivated in an indoor annular photobioreactor before being harvested and freeze-dried into dried biomass. The dried IG biomass was incorporated into four experimental diets in concentrations of 0% (diet A), 0.6% (diet B), 1.3% (diet C), 2.5% (diet D), and 5.0% (diet E) basal feed per kg. After 14 days of feeding, diet D has consistently improved the immune responses of innate immunity such as phagocytosis (P>0.05), respiratory burst (P<0.05), and lymphoproliferation (P<0.05) activities which might have helped in maintaining the overall health status of red hybrid tilapia. The orthogonal partial least squares (OPLS) model between diets D and A indicated three important metabolites, namely, isoleucine, glutamate, and tyrosine, have significantly been upregulated when compared to the control. Meanwhile, IG supplementation also resulted in lower concentrations of various metabolites in the spleen including α/β-glucose, choline, hypoxanthine, adenosine, and inosine. Hence, the application of metabolomics tools has proved the potential of IG-incorporated fish diet by strongly influencing the metabolic condition in red hybrid tilapia spleen cells and further boosting the immune response and health status in improving aquaculture health.
Solubilization and In Vitro Physical and Chemical Properties of the Amorphous Spray‐Dried Lactose‐Luteolin System
Authors: Dong Liping , Wang Bo , Chen Lin , Luo Min
Published: April 2022

Luteolin is a hydrophobic drug with low solubility, which has many limitations in practical use. To improve solubility, a spray drying technique was used to prepare complexes with lactose to promote the solubility and bioavailability of luteolin. The solution samples were spray dried using different ratios of water and ethanol as different dissolution media. By characterizing the spray‐dried powders obtained, we found that the solubility of the different groups of samples obtained by spray drying was improved, and similarly, their dissolution rates were also increased to different degrees. By comparison, both luteolin and the cofactor lactose were able to achieve high dissolution rates at suitable solution ratios and formed amorphous eutectic crystals after the spray drying process, which contributed well to the increased solubility and altered dissolution efficiency of luteolin.
Splenomegaly in a Patient with a History of Pernicious Anemia; the Potential Therapeutic Effects of B12 Therapy
Authors: Lordi Alexis , Ansari Nida , Maroules Michael , Manjegowda Anusha
Published: April 2022

Splenomegaly is manifested by a variety of etiologies, one of which is macrocytic anemia. Macrocytic anemia has multiple causes in itself that include; folate (Vitamin B9) and Cobalamin (vitamin B12) deficiencies. In this case report, we present a patient with a history of pancytopenia, macrocytic anemia and vitamin B12 deficiency, who underwent a splenectomy. The differential diagnoses for the cause of the patient’s splenomegaly included: lymphoma, infiltrative disease, and idiopathic splenomegaly. The pathology report from the splenectomy did not reveal any evidence of lymphoma or infiltrative disease, however, it did mention vascular congestion of the spleen. In theory, vascular congestion, due to extramedullary hematopoiesis in the spleen or sequestration of blood cell lineages, could lead to pancytopenia. In prior visits to the hospital this patient was diagnosed with: splenomegaly, and macrocytic anemia due to pernicious anemia. A splenectomy puts one at increased risk for infection by encapsulated organisms, and is to be avoided if possible. There are few case reports and studies that show vitamin B12 therapy can potentially cause a reversal in the splenomegaly as well as a reversal in the pancytopenia and macrocytic anemia. We hope to show that the least invasive treatment for vitamin B12, vitamin therapy, can be of use and effective.
Catheter-Directed Thrombectomy: An Alternative in Massive Pulmonary Embolism
Authors: Cordova Sanchez Andres , Vasigh Mostafa , Olatunde Oluwateniola , Chaudhuri Debanik
Published: April 2022

Massive pulmonary embolism (PE) is a life-threatening condition. The mainstay treatment is thrombolysis. Catheter-directed thrombectomy involves a group of new techniques that appear to have relatively low complications and mortality. These techniques have so far been studied mostly in submassive PE. We present a patient with massive PE that was successfully treated with catheter-directed thrombectomy.
Evolution of an Urban Network in the Yellow River Basin Based on Producer Services
Authors: Gong Weimin , Zhang Zhibin , Chen Long , Ma Xiaomin , Zhao Xuewei , Guo Yan
Published: April 2022

From the perspective of the producer services, a chain network model describes the evolution of an urban network in the Yellow River Basin and its mechanisms. The findings indicate the following phenomena: the spread of urban network connections in the basin and the proportional structure of cities at all levels show the characteristics of “flattening.” The network relationship within the basin has a clear spatial and hierarchical orientation, presenting a “core‐periphery” network structure and a “polarisation to trickle down” development model. The spatial organisation of the urban network societies in the river basin is remarkable. The closeness of the societies shows a trend at first decreasing and then increasing. The boundaries of the associations are consistent with the provincial administrative boundaries. The formation and evolution of the urban network in the basin have passed through the initial agglomeration stage, the hierarchical network formation stage, and the hierarchical network consolidation stage. From the perspective of influence mechanisms, proximity mechanisms, socio‐economic development, and advances in communication technology have significantly impacted the formation of the urban network structure in the Basin, while the level of science and technology education and the degree of openness to the outside world have had less influence on the promotion of network connections between cities.
CircLATS2 Regulates miR-520a-3p/E2F7/p-VEGFR2 Signaling Pathway to Promote Hepatocellular Carcinoma Progression and Angiogenesis
Authors: Wu Yefeng , Yuan Jianmao , Tu Zhengbin , Chen Huahua
Published: April 2022

Objective. To investigate the effect of circLATS2 on the progression and angiogenesis of hepatocellular carcinoma and its molecular mechanism. Methods. The expression of circLATS2 in hepatocellular carcinoma was detected by qRT-PCR. The StarBase database was used to predict the potential miRNA, and the combination of the above was cytological verified by luciferase reporter gene assay and RNA pull down. The potential target genes of miRNA were predicted by TargetScan, verified by the above experiments, and the influence of circLATS2 on its expression was determined. The biological function of circLATS2 was investigated by in vitro and in vivo experiments. The effects of miRNA and target genes on the malignant behavior of HCC cells were determined by the reverse experiment. Results. circLATS2 was highly expressed in HCC and was positively correlated with tumor size and tumor stage. miR-520a-3p was sponged by circLATS2 and was low expressed in HCC tissues. As the target gene of miR-520a-3p, the expression level of E2F7 is affected by circLATS2. In vitro experiments showed that circLATS2 knockdown inhibited the proliferation, clone formation, migration, and invasion ability of hepatocellular carcinoma cells. In vivo knockdown of circLATS2 inhibits the proliferation of HCC cells, while overexpression of circLATS2 promotes the proliferation of HCC cells. Overexpression of miR-520a-3p and E2F7 knockdown reversed the role of circLATS2 in promoting malignant behavior of HCC cells and affected phosphorylation of VEGFR2. Conclusion. CircLATS2 promotes the progression of HCC by regulating miR-520a-3p/E2F7/P-VEGFR2 signaling pathway.
Effects of the Antiobesity Drugs Aplex and Venera on Certain Biochemical and Physiological Indices in Obese Adult Male Albino Rats
Authors: Elpasty Suzan S. A. , Helal Eman G. E. , Algendy Ashraf M. M. , Yousef Hany N.
Published: April 2022

Background. Because of the growing incidence of obesity, the use of synthetic antiobesity medicines as weight-loss agents has grown in popularity, although their usefulness has yet to be established. Two of such medicines are Aplex and Venera. This study is designed to determine the potential dangers of Aplex and Venera on certain biochemical and physiological indicators in obese adult male rats. Methods. Twenty-one obese male albino rats (9 weeks old and having a body mass of 220 ± 20 g) were divided into three equal groups: the control group (vehicle treatment), the Aplex group (0.1 mg/kg/day) for 30 days, and the Venera group (0.1 mg/kg/day) for 30 days. Results. The values of serum glucose, insulin, homeostatic model assessment of insulin resistance (HOMA-IR), total protein, total cholesterol (TC), high-density lipoprotein (HDL), very-low-density lipoprotein (VLDL), TC/HDL ratio, testosterone, thyroxine (T4), and leptin did not differ significantly between the treated and control groups. In contrast, the treated groups had substantial changes in bodyweight, serum alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), albumin, globulin, albumin/globulin ratio (A/G ratio), triglycerides (TG), low-density lipoproteins (LDL), LDL/HDL ratio, urea, creatinine, and triiodothyronine (T3) levels. Conclusion. The findings indicate that Aplex and Venera have negative impacts on crucial biochemical and physiological indicators, particularly liver and kidney functioning.
Concomitant MPZ and MFN2 Gene Variants and Charcot Marie Tooth Disease in a Boy: Clinical and Genetic Analysis—Literature Review
Authors: Comella M. , Collotta A. , Pavone V. , Ciccia L. , Bellinvia A. , Cerruto C. , Biondi M. G. L. , Pisani F. , Pavone P.
Published: April 2022

Charcot- Marie- Tooth (CMT) disease includes a group of clinically and genetically heterogeneous neuropathic disorders with an estimated frequency of 1 on 2.500 individuals. CMTs are differently classified according to the age of onset, type of inheritance, and type of inheritance plus clinical features. For these disorders, more than 100 genes have been implicated as causal factors, with mutations in the PMP22 being one of the most common. The demyelinating type (CMT1) affects more than 30% of the CMTs patients and manifests with motor and sensory dysfunctions of the peripheral nervous system mainly starting with slow progressive weakness of the lower extremities. We report here a 12 year- old boy presenting with typical features of CMT1 type, hearing impairment, and inguinal hernia who at the next-generation sequence analysis displayed a concomitant presence of two variants: the c.233 C>T p.Ser 78Leu of the MPZ gene (NM_000530.6) characterized as pathogenetic and the c.1403 G>A p.Arg 468His of the MFN2 gene (NM_014874.3) characterized as VUS. Concomitant variant mutations in CMTs have been uncommonly reported. The role of these gene mutations on the clinical expression and a literature review on this topic is discussed.
A Depth Camera‐Based Intelligent Method for Identifying and Quantifying Pavement Diseases
Authors: Bai Hao , Hu Xiangyu , Chen Fei , Liao Zhiyong , Li Kai , Ran Guangjiong , Wei Fengni
Published: April 2022

In this study, a depth camera‐based intelligence method is proposed. First, road damage images are collected and transformed into a training set. Then training, defect detection, defect extraction, and classification are performed. In addition, a YOLOv5 is used to create, train, validate, and test the label database. The method does not require a predetermined distance between the measurement target and the sensor; can be applied to moving scenes; and is important for the detection, classification, and quantification of pavement diseases. The results show that the sensor can achieve plane fitting at investigated working distances by means of a deep learning network. In addition, two pavement examples show that the detection method can save a lot of manpower and improve the detection efficiency with certain accuracy.
Prevalence of Intestinal Parasitic Infections and Their Associated Risk Factors among Pregnant Women Attending Antenatal Care Center at Woreilu Health Center, Woreilu, Northeast Ethiopia
Authors: Kebede Edosa , Asefa Netsanet , Daba Chala , Gebretsadik Daniel
Published: April 2022

Background. Intestinal parasitic infections (IPIs) affect millions of pregnant women worldwide and if left untreated can cause adverse effects for mothers, fetuses, and newborns. This study was aimed at determining the prevalence and associated risk factors of intestinal parasitic infections among pregnant women in Woreilu, Northeast Ethiopia. Methods. A cross-sectional study was conducted in Woreilu Health Center from October 2018 to February 2019. A convenient sampling technique was used to select the study subjects. The data related to the sociodemographic information and associated risk factors were collected by the interview technique, and fresh stool samples were collected from each pregnant woman. The microscopic examination of the stool samples was done by using direct wet mount preparations in normal saline and formol ether concentration techniques. Descriptive statistics and binary logistic regression were used. A

p

value < 0.05 was taken as statistically significant. Results. A total of 331 pregnant women were included. The

mean
±
standard
 
deviation

of age of the participants was

26.3
±
5.96

years ranging between 16 and 43 years. The overall prevalence of IPIs was 144 (43.5%) with the predominance of E. histolytica/dispar (44.4%) followed by A. lumbricoides (15.7%). Being a student (

AOR
=
3.35

, 95% CI: 1.01-11.09,

p
=
0.047

), second trimester (

AOR
=
3.94

, 95% CI: 1.46-10.64,

p
=
0.007

), third trimester (

AOR
=
3.32

, 95% CI: 1.15-9.6,

p
=
0.027

), and using spring water for drinking (

AOR
=
2.91

, 95% CI: 1.62-5.22,

p
≤
0.001

) were significantly associated with IPIs. Conclusion. The prevalence of IPIs was high in this study. Being a student, second and third trimester, and using spring water for drinking were associated factors with IPIs. Therefore, improving the sanitation of the students and providing clean drinking water for the women should be strengthened. Screening women and providing health education during their antenatal care (ANC) visits are also recommended.
Generalization of Tangential Complexes of Weight Three and Their Connections with Grassmannian Complex
Authors: Hussain Sadaqat , Kausar Nasreen , Kousar Sajida , Kattel Parameshwari , Shahzad Tahir
Published: April 2022

Following earlier work by Gangl, Cathelineaue, and others, Siddiqui defined the Siegel’s cross-ratio identity and Goncharov’s triple ratios over the truncated polynomial ring

F

ε

ν

. They used these constructions to introduce both dialogarithmic and trilogarithmic tangential complexes of first order. They proposed various maps to relate first-order tangent complex to the Grassmannian complex. Later, we extended all the notions related to dialogarithmic complexes to a general order

n

. Now, this study is aimed to generalize all of the constructions associated to trilogarithmic tangential complexes to higher orders. We also propose morphisms between the tangent to Goncharov’s complex and Grassmannian subcomplex for general order. Moreover, we connect both of these complexes by demonstrating that the resulting diagrams are commutative. In this generalization process, the classical Newton’s identities are used. The results reveal that the tangent group

T

B
3
n

F

of a higher order and defining relations are feasible for all orders.
Target Protein for Xklp2 Functions as Coactivator of Androgen Receptor and Promotes the Proliferation of Prostate Carcinoma Cells
Authors: Sun Baisheng , Long Yin , Xiao Ling , Wang Jiazhi , Yi Qian , Tong Dali , Li Ke
Published: April 2022

The activation of the androgen receptor (AR) pathway is crucial in the progression of human prostate cancer. Results of the present study indicated that the target protein xenopus kinesin-like protein (TPX2) enhanced the transcription activation of AR and promoted the proliferation of LNCaP (ligand-dependent prostate carcinoma) cells. The protein-protein interaction between AR and TPX2 was investigated using coimmunoprecipitation assays. Results of the present study further demonstrated that TPX2 enhanced the transcription factor activation of AR and enhanced the expression levels of the downstream gene prostate-specific antigen (PSA). TPX2 did this by promoting the accumulation of AR in the nucleus and also promoting the recruitment of AR to the androgen response element, located in the promoter region of the PSA gene. Overexpression of TPX2 enhanced both the in vitro and in vivo proliferation of LNCaP cells. By revealing a novel role of TPX2 in the AR signaling pathway, the present study indicated that TPX2 may be an activator of AR and thus exhibits potential as a novel target for prostate carcinoma treatment.
In Vivo Anti-Inflammatory, Analgesic, Muscle Relaxant, and Sedative Activities of Extracts from Syzygium cumini (L.) Skeels in Mice
Authors: Rauf Abdur , Al-Awthan Yahya S. , Khan Imtaiz Ali , Muhammad Naveed , Ali Shah Syed Uzair , Bahattab Omar , Al-Duais Mohammed A. , Sharma Rohit , Rahman Md. Mominur
Published: April 2022

In the current study, the folklore medicine, Syzygium cumini, was experimentally evaluated for anti-inflammatory, analgesic, sedative, and muscle relaxant effects. The extract and fractions of S. cumini were found safe up to 1000 mg/kg with no mortality, except for slight sedation as a minor side effect. Both, the extract and various fractions of S. cumini demonstrated significant inhibition (86.34%) of carrageenan-induced inflammation in mice. Acetic acid induced writhes were attenuated (

p
<
0.001

) by S. cumini in a dose-dependent manner, except for the n-hexane fraction. The maximum effect was observed at a dose of 500 mg/kg in mice. The maximum muscle relaxant effect of all tested samples was recorded at a dose of 500 mg/kg bodyweight, where the percent inhibition exhibited by dichloromethane fraction was 82.34%, followed by chloroform fractions (71.43%) and methanolic extract (70.91%). Our findings validate the folklore medicinal claims of S. cumini, as an analgesic and anti-inflammatory agent.
A Method Design of English Teaching System Based on Video Feedback Method
Authors: Li Yizhi , Gou Yalan
Published: April 2022

The traditional English teaching mode is that the teacher simply imparts textbook knowledge and students understand and absorb it. However, this method has obvious problems; that is, it is difficult to ensure that students can quickly understand the content taught and cannot get fast feedback. The video feedback method is a method of English teaching combined with audiovisual technology. Teachers can use video technology to record key English knowledge through video and then give feedback and explain the learning through video. At the same time, the intelligent video feedback system teaching method will greatly improve the teaching quality of English classroom and make students’ learning more fun. This paper mainly designs the English teaching system based on the video feedback method and finally realizes the intelligent feedback scheme of the English teaching system. Firstly, the neural network method, classification method, and video shooting technology are used to extract and predict the characteristics of students’ classroom expressions, speech, and so on, and analyze through the video feedback system of English classroom. The research results show that the classification method proposed in this study can better complete the body movements such as student expressions and speech collected by the English teaching system, and the neural network method can more accurately predict and feed back the teaching content through the video feedback method with the largest error. It was only 2.98%, and the linear correlation also reached more than 0.98. The minimum error of the video feedback information is only 0.95%, and the prediction errors of the other two kinds of English classroom information are also 2%. The classification and prediction of intelligent video feedback information have achieved good results.
Antioxidant and Anticholinesterase Properties of the Aqueous Extract of Balanites aegyptiaca L. Delile Fruit Pulp on Monosodium Glutamate-Induced Excitotoxicity in Swiss Mice
Authors: Parfait Bouvourné , Galba Jean Beppe , Roger Ponka , Hervé Hervé Ngatanko Abaissou , Balbine Kamleu Kwingwa , Guillaume Camdi Woumitna , Simon Desire Guedang Nyayi , Linda Damo Kamda Jorelle , Léa Blondelle Kenko Djoumessie , Germain Sotoing Taiwe
Published: April 2022

Balanites aegyptiaca L. Delile (B. aegyptiaca) is used in traditional medicine for the treatment of memory impairment. This work aims to evaluate the antioxidant and anticholinesterase potential of BA fruit pulp extract on excitotoxicity induced by monosodium glutamate (MSG). MSG was administered 30 minutes after treatment with B. aegyptiaca aqueous fruit pulp extract (50, 125, 250, and 500 mg/kg) and vitamin C (100 mg/kg) for 30 days. The negative control group received only MSG, while the control group was given distilled water daily. Behavioral tests parameters (using the novel object recognition, Y-maze, and Barnes maze tests), oxidative stress biomarkers (malondialdehyde, superoxide dismutase, and catalase), nitric oxide, and acetylcholinesterase activity and hippocampal architecture were evaluated. Results obtained revealed that different doses of B. aegyptiaca significantly reversed the deleterious effect of MSG on memory. This was displayed by a significant (

p
<
0.05

) increment in the percentage of spontaneous alternation in the Y-maze test and a significant (

p
<
0.001

) increase in discrimination index in novel object recognition observed with 500 mg/kg extract dose. Moreover, the extract (250 and 500 mg/kg doses) significantly (

p
<
0.001

) increased direct search strategy and significantly decreased (

p
<
0.01

) the time taken to find the target hole in the Barnes maze. A modulation of hyperactivity was observed after administration of all extract doses compared to the negative control group in the open arena. Furthermore, the highest dose of the extract caused a significant (

p
<
0.001

) improvement in antioxidant enzymes activity, associated with a significant (

p
<
0.001

) decrement in nitric oxide and malondialdehyde concentrations and a significant (

p
<
0.01

) decrease in acetylcholinesterase activity. Treatment with the extract also restored normal hippocampal cell architecture. B. aegyptiaca fruit pulp extract could thus confer neuroprotection through its antioxidant and anticholinesterase potential.
Cooperative Production Behavior of Fresh Agricultural Product Suppliers under Regional Product Standardization Construction
Authors: Yang Yang , Yao Guanxin , Fan Xueru
Published: April 2022

From the perspective of regional product standardization construction, the evolutionary game models of standardized collaborative production of fresh agricultural product suppliers with or without government participation were built respectively, and the stability of the main strategy choice was discussed. The results show that when the standardization of regional fresh agricultural product is low and the participants' willingness to cooperate is high, the government can choose not to participate in the guidance, but if the government participates in the guidance but does not participate properly, it will have a reverse inhibition effect. When the standardization degree of regional fresh agricultural product is high, the government must effectively guide and regulate, regardless of the initial will of the participants. When government participation is effective, standardized production subsidies can promote the choice of collaborative strategies, while revenue‐sharing mechanism and cost‐sharing mechanism have little effect.
Research on the Detection Technique of Situation Elements in Obscure Overlapping Scenes
Authors: Liu Jinlong , Cheng Kangda
Published: April 2022

In recent years, some scholars have proposed to apply single-stage target detection algorithms such as YOLO (You Only Look Once) to situational element detection, but the traditional YOLO algorithm is to treat the target detection process as a regression problem, which cannot distinguish well between overlapping objects and has defects such as less accurate bounding boxes and hard to distinguish objects from the background, and it is difficult to cope with problems such as the higher overlap of targets to be detected and stronger target camouflage ability in obscured overlapping scenes. In this paper, we propose to add the attention module CBAM to the backbone network of the YOLOv3 model, to construct a SEDNet with high accuracy and good robustness for situational element detection, and to apply it to the situational element detection in occlusion overlapping scenes. We use SEDNet to classify and localize ten elemental targets, respectively. The analysis of experimental results shows that the SEDNet target detection model can complete element detection in complex environments with strong target camouflage, achieve end-to-end detection, and lay the technical foundation for the formation of complete situational awareness.
Association between P-Selectin Autoantibody Positive and Response to Steroid Treatment in Newly Diagnosed Immune Thrombocytopenia Patients
Authors: Wang Li , Wang Dong-Dong , Jiao Rui-Ying , Liu Chang-Xun , Hou Yan-Qiu , Qin Hui , He Hong-Jie
Published: April 2022

Objective: This study aimed to detect the association between P-selectin autoantibody positive and response to steroid treatment in newly diagnosed immune thrombocytopenia (ITP) patients. Methods: The data from 105 newly diagnosed adult ITP patients administered with first-line of steroid treatment from October 2016 to May 2021 were retrospectively analyzed. Treatment responses were evaluated within 3 months after the onset of treatment. Results: Among the 105 patients, 80.00% (84/105) of patients presented with platelet glycoprotein-specific antibody positive; 44.76% (47/105) patients were anti-P-selectin positive, while 35.24% (37/105) were anti-P-selectin negative. No significant difference in overall response was observed between patients who were anti-P-selectin positive and those who were anti-P-selectin negative (74.47% vs. 89.19, χ2 = 2.910, p = 0.088). But patients who were anti-P-selectin negative had significantly higher complete response rate, compared to those who were anti-P-selectin positive (72.97% vs. 48.94%, χ2 = 4,965, p = 0.026). Logistic regression analysis revealed that anti-GP IIb/IIIa positive (OR = 3.114, p = 0.010, 95% CI: 1.313–7.388) and anti-P-selectin positive (OR = 0.309, p = 0.036, 95% CI: 0.127–0.753) were two factors that could affect patients’ response. Conclusions: Our study found that ITP patients with anti-GP IIb/IIIa may have a higher response to steroid treatment, but anti-P-selectin-mediated-ITP might be less responsive to steroid treatment. In adults with ITP, the presence of anti-P-selectin autoantibodies is a predictive factor for poor response to steroid treatment.
Francis Turretin’s Thomistic Theology of Natural Law
Authors: Saad Toni C.
Published: April 2022

In contrast to much contemporary Reformed and broader evangelical theology, Francis Turretin, the great Genevan theologian of High Orthodoxy, considers natural law in favorable terms, notably under Topic 11 of his Institutes of Elenctic Theology. This essay offers an exposition of Turretin’s account of natural law and compares it to that of Thomas Aquinas. It is shown that there is substantial agreement between Turretin and Aquinas on the notion and content of natural law, despite their different approaches to the subject. This conclusion supports ongoing efforts to reevaluate and reappropriate natural law and Thomism in Reformed theology.
Colin Gunton and John Calvin on the Via Negativa and Theological Projection
Authors: McCray Alden C.
Published: April 2022

This article contrasts two approaches to the via negativa in the work of Colin Gunton and John Calvin. After examining Gunton’s allegation that unbiblical causal and hierarchical commitments within the negative way describe God by projecting the negation of creaturely attributes, it argues that the scriptural exegesis of John Calvin illuminates some of the shortcomings of these critiques. Calvin’s close engagement with scriptural texts about divine alterity demonstrates how the via negativa may be a form of biblical reasoning and highlights the utility of exegesis for discerning the biblical logic of traditional modes of divine naming.
7. Organising Common Good Dynamics
Authors: De la Torre Rodolfo
Published: April 2022

In this chapter, Rodolfo de la Torre explores a possible metric for the justice component of the common good matrix. He structures his reflection through three major points. (a) Justice cannot be reduced to a separate dimension, isolated from the agency, humanity, governance and stability components of the common good. However, it makes sense to distinguish this dimension for analytical and measurement purposes. (b) It is convenient to conceptualise the component of justice of the common good as dealing with the fair generation of social goods and the possibility of shared benefits. So procedural and distributional aspects of justice are and must be involved. (c) Freedoms and rights are ways to approach the procedural aspects of justice. Equality of results and equality of opportunity are key to its distributional aspects. Both elements play a role in the concept of justice and should therefore be the feature on which indicators for the dimension of justice are based.
How I prevent GVHD in high-risk patients: posttransplant cyclophosphamide and beyond
Authors: Rimando Joseph , McCurdy Shannon R. , Luznik Leo
Published: April 2022

Advances in conditioning, graft-versus-host disease (GVHD) prophylaxis and antimicrobial prophylaxis have improved the safety of allogeneic hematopoietic cell transplantation (HCT), leading to a substantial increase in the number of patients transplanted each year. This influx of patients along with progress in remission-inducing and posttransplant maintenance strategies for hematologic malignancies has led to new GVHD risk factors and high-risk groups: HLA-mismatched related (haplo) and unrelated (MMUD) donors; older recipient age; posttransplant maintenance; prior checkpoint inhibitor and autologous HCT exposure; and patients with benign hematologic disorders. Along with the changing transplant population, the field of HCT has dramatically shifted in the past decade because of the widespread adoption of posttransplantation cyclophosphamide (PTCy), which has increased the use of HLA-mismatched related donors to levels comparable to HLA-matched related donors. Its success has led investigators to explore PTCy’s utility for HLA-matched HCT, where we predict it will be embraced as well. Additionally, combinations of promising new agents for GVHD prophylaxis such as abatacept and JAK inhibitors with PTCy inspire hope for an even safer transplant platform. Using 3 illustrative cases, we review our current approach to transplantation of patients at high risk of GVHD using our modern armamentarium.
Rhabdomyolysis induced by rosuvastatin combined with entecavir: a case report
Authors: Wang Wen , Lu Xu , Li Chengbo , Teng Wei , Cui Wei
Published: April 2022

Background

Rhabdomyolysis is a serious and potentially life threatening condition that can be caused by drugs. We report a case of acute hepatitis B with rhabdomyolysis after treatment with rosuvastatin and entecavir.

Case presentation

A 72-year-old female was admitted to our hospital due to acute hepatitis B infection. She had taken atorvastatin for 3 months before being admitted to our hospital. After being administered entecavir (ETV) and rosuvastatin to replace atorvastatin, she suffered from muscle pain in both lower limbs and was diagnosed with rhabdomyolysis. After discontinuation of the two drugs, the patient's symptoms subsided and creatine kinase levels returned to normal. We hypothesize that the rhabdomyolysis was caused by the combination of rosuvastatin and ETV.

Conclusions

We suggest that patients who use rosuvastatin and ETV be made aware of the complication of rhabdomyolysis.
Specific T-cell responses for guiding treatment with convalescent plasma in severe COVID-19 and humoral immunodeficiency: a case report
Authors: Nyström Katarina , Hjorth Maria , Fust Ramona , Nilsdotter-Augustinsson Åsa , Larsson Marie , Niward Katarina , Nyström Sofia
Published: April 2022

Background

The immune response to SARS-CoV-2 virus, the cause of COVID-19, is complex. Antibody mediated responses are important for viral clearance but may also drive hyperinflammation in severe COVID-19. We present a case of an individual with a genetic inability to produce antibodies and severe COVID-19, receiving no other specific anti-viral treatment than convalescent COVID-19 plasma, illustrating that hyperinflammation can occur in the absence of a humoral anti-viral response. In addition, the case illustrates that the assessment of SARS-CoV-2 T cell responses can facilitate clinical decision making in patients with COVID-19 and weak or absent humoral immune responses.

Case presentation

A male with X-linked agammaglobulinemia on regular immunoglobulin replacement therapy, hospitalized for 35 days due to severe COVID-19. Systemic inflammatory parameters were highly elevated. After treatment with convalescent COVID-19 plasma he became afebrile and the fatigue diminished. He was discharged on day 42 and nasopharyngeal SARS-CoV-2 PCR eventually was negative on day 49. Evidence of SARS-CoV-2 specific T cells prior to administration of plasma therapy suggested that antibodies were crucial for viral clearance. Regular assessment showed robust and persistent SARS-CoV-2 specific T-cell responses after recovery suggested that prophylactic administration of convalescent COVID-19 plasma was unnecessary.

Conclusion

Assessment of SARS-CoV-2T-cell responses can facilitate the clinical management of COVID-19 patients with humoral immunodeficiencies.
A hypothyroid mother after subtotal thyroidectomy delivered a newborn with hyperthyroidism from fetal stage: a case report
Authors: Peng Cheng , Sun Weijie , Fan Lixin , Li Li , Zhang Xiaojiao , Gao Ying , Hou Xinlin
Published: April 2022

Background

Neonatal hyperthyroidism is an extension of fetal disease. Most cases of neonatal hyperthyroidism are transient but may excessively harm multiple organ functions through the actions of maternal thyroid-stimulating hormone receptor antibodies on the neonatal thyroid gland.

Case presentation

The hyperthyroid mother underwent subtotal thyroidectomy before pregnancy and regularly took levothyroxine to avoid hypothyroidism, but still had a high-level thyroid-stimulating hormone receptor antibody (TRAb). The neonate suffered from hyperthyroidism due to the transplacental TRAb. After a regular medication schedule of an antithyroid drug, combined with a β-blocker to control the ventricular rate, the infant gradually recovered, allowing normal motor and intellectual development.

Conclusions

Maternal subtotal thyroidectomy cannot prevent the secretion of thyroid receptor antibodies, which may cause either hypothyroidism or hyperthyroidism. The balance between antithyroid drugs and levothyroxine is critical in clinical practice.