bluuebunny/crossref_metadata_2025 huggingface dataset:
La Tecnología y su Contribución en las Comunidades Indígenas de la Amazonía, los Andes y el Atlántico
Authors: Meregildo Toribio Walter Bayron , López Moncada Gloria Victoria
Published: September 2024

Esta investigación se alinea con el Objetivo de Desarrollo Sostenible (ODS) 15, "Vida de ecosistemas terrestres", evaluando cómo la integración de la tecnología puede apoyar la gestión territorial y satisfacer las necesidades culturales y socioeconómicas de las comunidades indígenas en el corredor Triple A. Los objetivos específicos fueron: Examinar la influencia de estas tecnologías en las prácticas de gestión territorial y toma de decisiones; identificar las necesidades y desafíos en el acceso, uso y apropiación de la tecnología; y diseñar un programa tecnológico adaptado a las características culturales y socioeconómicas de estas comunidades. El tipo de investigación es cualitativa, basada en el análisis documental, la población en estudio incluyó documentos relevantes sobre la implementación de tecnologías avanzadas de monitoreo ambiental. Los principales resultados indican que la adopción de tecnologías como drones, GPS y sistemas de alerta temprana ha mejorado significativamente la capacidad de monitoreo y toma de decisiones de las comunidades indígenas, sin embargo, enfrentan desafíos en el acceso y asequibilidad de la infraestructura tecnológica, así como en la alfabetización digital. Las conclusiones destacan que la integración de estas tecnologías, respetando los valores culturales y conocimientos tradicionales, fortalece la autonomía comunitaria y promueve un desarrollo sostenible. Se diseñó un programa tecnológico que incluye el desarrollo de infraestructura sostenible y programas de capacitación adaptados culturalmente, asegurando así que las soluciones sean relevantes y efectivas.
Estrategias biotecnológicas avanzadas para la optimización de la diversidad genética y la propagación vegetativa en Swietenia macrophylla
Authors: Carranza-Patiño Mercedes Susana , Marín-Cuevas Carmen Victoria , Herrera-Feijoo Robinson Jasmany , Torres-Rodríguez Juan Antonio , Espinoza-Torres Mary Cruz
Published: September 2024

Swietenia macrophylla (caoba) es una especie arbórea de alto valor ecológico y económico, actualmente en peligro crítico por la sobreexplotación. Esta revisión analiza las estrategias biotecnológicas más recientes para conservar su diversidad genética y mejorar su propagación vegetativa. Se revisaron estudios publicados entre 2019 y 2024 mediante una búsqueda en bases de datos como Web of Science y Scopus, siguiendo el protocolo PRISMA. Los estudios incluyen la embriogénesis somática, la micropropagación y el uso de marcadores moleculares. Los resultados destacan que la embriogénesis somática y la micropropagación son técnicas prometedoras para clonar individuos genéticamente valiosos, lo que ayuda a preservar genotipos adaptativos. Los marcadores moleculares permiten identificar genotipos con mayor capacidad de supervivencia. Sin embargo, persisten grandes retos, como la pérdida de viabilidad de las semillas y la fragmentación del hábitat. Las tecnologías emergentes, como la edición genética y la secuenciación de nueva generación (NGS), ofrecen oportunidades para mejorar los programas de conservación. A pesar de los avances, es necesario optimizar los métodos de propagación vegetativa y asegurar la viabilidad de los clones en condiciones de campo. Un enfoque integral que considere la genética, la ecología y el cambio climático es crucial para la conservación de la caoba.
Desarrollo y Validación de Modelos de Aprendizaje Online para la Mejora de la Calidad Educativa
Authors: Abad Basantes Cristian Augusto , Toscano Quispe Silvia Yolanda , Sarango Romero Verónica Janeth , Alvear Loor Jessica Geovanna
Published: September 2024

Este artículo revisa el desarrollo y validación de modelos de aprendizaje en línea para mejorar la calidad educativa. El estudio se sitúa en el contexto actual de la educación digital, impulsada principalmente por la pandemia de COVID-19, que aceleró la adopción de plataformas de enseñanza en línea. Se emplearon técnicas de análisis de ecuaciones estructurales (PLS-SEM) para validar modelos que integran tecnologías emergentes como la gamificación y el análisis de datos. Los resultados muestran un impacto positivo en la satisfacción estudiantil, el rendimiento académico y la participación activa. Sin embargo, también se identificaron limitaciones, como la desigualdad en el acceso a la infraestructura tecnológica y la falta de formación docente. A pesar de estos desafíos, los modelos de aprendizaje en línea representan una oportunidad importante para la educación inclusiva y personalizada. Se concluye que es necesario un enfoque más amplio que incluya políticas educativas que favorezcan el acceso equitativo a la tecnología y promuevan la capacitación docente. Además, se sugiere que futuras investigaciones se centren en el desarrollo de modelos más flexibles y adaptables a diferentes contextos.
Pretpostavke za povećanje osnovnog kapitala iz neto imovine (pretvaranjem neraspoređene dobiti ili rezervi u osnovni kapital) društva s ograničenom odgovornošću
Authors:   Faculty of Law Novi Sad, Marjanski Vladimir
Published: September 2024

The increase in the share capital from the funds of the limited liability company represents a nominal increase in the share capital, which is carried out by converting retained profit or dedicated reserves into share capital. The main economic purpose of increasing the basic capital from the company’s assets is to strengthen the company’s creditworthiness, which is achieved by fully or partially tying free accounting assets (retained profit or reserves) to the share capital. Before implementing this method of increasing the share capital, it is necessary to fulfil certain legal and accounting assumptions. The focus of the analysis in this paper refers to the fulfilment of the legal and accounting assumptions for converting retained profit and reserves into share capital and the limitations for implementing this way of increasing the share capital of a limited liability company. In addition to the above, we single out as particularly important considerations related to reserve assets, in relation to which there is a very modest regulation in the Serbian Law on Business Companies.
O ensino da música em regime articulado em Portugal: possibilidade pedagógica para a aprendizagem de um instrumento musical
Authors: Ribeiro António José Pacheco
Published: September 2024

O presente trabalho discorre sobre o ensino da música em Portugal e os seus diferentes contextos, nomeadamente o ensino genérico e o ensino artístico especializado: vocacional e profissional. Centra-se, particularmente, no ensino vocacional da música, que se desenvolve nos conservatórios e academias, e tem como principal objetivo identificar estratégias que possibilitem práticas pedagógicas articuladas com as escolas do ensino genérico. O trabalho desenvolveu-se no âmbito da aprendizagem de um instrumento musical (Guitarra), considerando as metodologias e os propósitos educativos deste subsistema de ensino vocacional, e foi levado a cabo, durante dois anos letivos,  no Conservatório do Vale do Sousa, Lousada, com dois grupos de alunos diferenciados: um grupo de alunos do ensino vocacional e outro grupo de alunos do ensino genérico. Neste sentido, aborda a problemática do acesso ao ensino da música, depois da sua inserção no sistema geral de ensino, e refere o regime de ensino articulado como o modelo de frequência capaz de promover um ensino instrumental da música sustentado para uma população mais abrangente.
Alfabetização de alunos com Transtorno Opositivo Desafiador: estratégias, desafios e colaborações
Authors: Manso Mariana dos Santos , Farias Elizabeth Regina Streisky de
Published: September 2024

Este artigo aborda o processo de alfabetização para estudantes com Transtorno Opositivo Desafiador (TOD), explorando os desafios específicos que esses alunos enfrentam e as estratégias pedagógicas eficazes para melhorar seu desempenho acadêmico. Inicialmente, são discutidas as características do TOD e sua prevalência crescente, atribuída à maior conscientização e aos avanços nos métodos de diagnóstico. Em seguida, analisa-se o impacto do TOD na aprendizagem e no ambiente escolar, destacando as dificuldades de atenção, comportamento disruptivo e interações sociais problemáticas. São apresentadas estratégias de alfabetização adaptadas, como ensino multisensorial, instrução direta e segmentação de tarefas, que visam atender às necessidades específicas desses alunos. O trabalho também enfatiza a importância da colaboração multidisciplinar, envolvendo professores, profissionais de saúde e famílias, para o desenvolvimento de planos de intervenção individualizados que promovam um ambiente de aprendizagem inclusivo e eficaz. Os resultados indicam que essas abordagens podem melhorar significativamente o processo de alfabetização para estudantes com TOD.
Transformações bioquímicas envolvidas no processo de amadurecimento das frutas
Authors: Sousa Ana Karoline Lopes de , Oliveira Karla Nayane Ribeiro de , Lobato Lyvia de Moraes , Carvalho Aline Roseiro , Silva Breno Mendes da , Barros Schirley Alves de Freitas Strafacci Pevidor de , Nascimento Denize Maria Calixto , Alves Hiago Emanuel de Oliveira
Published: September 2024

Com a diversa capacidade de produção agrícola do Brasil, explorar ao máximo as possibilidades econômicas deste ramo, contribuem para a movimentação da economia do país e alavanca a agricultura brasileira diante do mundo. Dentre os principais cultivos do país estão as frutas, que muitas vezes são exportadas, e assim necessitam do maior tempo de vida útil de prateleira possível, sendo que para isso é fundamental conhecer inicialmente as transformações e os processos que ocorrem durante o seu amadurecimento, como quais reações, enzimas e estruturas envolvidas. Diante disso, objetivou-se abordar as transformações bioquímicas que ocorrem durante o amadurecimento das frutas. O amadurecimento dos frutos engloba alterações na distribuição dos polissacarídeos da pectina, hemicelulose e celulose da parede celular, que ocorrem como uma série coordenada de passos, além de contar com a participação do etileno, e para prolongar sua vida útil é necessário a utilização de diferentes tecnologias que não afetem suas características principais e mantenham seu valor comercial.
Os pentecostais e a conquista do campo político no contexto do Bolsonarismo
Authors: Costa Moab César Carvalho , Ferreira Renan Almeida
Published: September 2024

Desde a redemocratização, a política brasileira tem sido marcada pela crescente influência dos pentecostais, que ganham cada vez mais espaço no Poder Legislativo e exercem impacto na escolha do chefe do Poder Executivo Federal. Este artigo analisa as relações entre religião e política no Brasil, com foco nos pentecostais no contexto do bolsonarismo. No decurso das últimas décadas, observou-se um aumento constante de candidatos pentecostais eleitos a cada legislatura, e uma busca crescente de candidatos presidenciais pela aprovação das lideranças evangélicas devido à importância do eleitorado pentecostal e suas tendências ideológicas voltadas para a direita. A pesquisa, dentro dos limites da História do Tempo Presente, acompanhou o processo político que levou à recondução de Luís Inácio Lula da Silva à Presidência. A eleição de Bolsonaro em 2018 foi fortemente influenciada pelo voto pentecostal, muitos analistas afimam que foi decisivo, e no pleito de 2022, esse apoio se intensificou, embora não tenha garatido a reeleição de Bolsonaro, tornou-se um marco na construção do bolsonarismo e da direita cristã no Brasil.
Territories of the «northern delivery»: new approaches to categorization
Authors: Kubicheck Vitaly V. , Igithanyan D. A. , Brikotnina N. V.
Published: September 2024

Ensuring the sustainability of settlements in the Far North regions is achievable only through a comprehensive set of measures for the procurement and delivery of essential goods (primarily food and fuel) from other areas, known as the «Northern Delivery» The current supply system is marked by inefficiencies that create high risks of delivery disruptions. Enhancing this system requires developing and implementing optimal measures to influence the economic relationships within the «Northern Delivery» framework, alongside determining effective legal regulatory methods. A critical step in this process is the establishment of precise and strictly defined territorial boundaries for implementing these measures. At present, there is no legal formalization of spatial limits for the array of managerial, logistic, and socio-economic processes aimed at ensuring uninterrupted deliveries of goods for the «Northern Delivery» underscoring the importance of this research. The aim of this study is to define the criteria and their quantitative parameters to categorize the regions of the Far North and equivalent areas with limited cargo delivery periods. By synthesizing the work of both domestic and international scholars on the zoning of northern territories and assessing their transport accessibility, as well as utilizing cartographic research methods and focus groups, an algorithm for categorizing the settlements of the Far North regions has been developed. The identified selection criteria include transport accessibility, the presence of stable supply logistics chains, the duration of heating period, and the level of provision with basic food products. This categorization resulted in identifying of three groups of territories based on the supply organization mechanism: critical, supporting, and basic supply. The proposed categorization can be used to determine the spatial limits for legal regulation of the «Northern Delivery» and to develop a specific set of measures to ensure the uninterrupted delivery of essential goods.
Artificial neural networks in economics: mathematical tool, model or methodology?
Authors: Petrunin Yuri Yu.
Published: September 2024

The purpose of this article is to assess the current interaction between artificial intelligence (AI) and economic science and to identify promising interdisciplinary areas of research that can significantly influence the methodology of understanding economic phenomena. To achieve this goal, the vague and partly even mystical term AI was replaced with а more scientific term «artificial neural networks» (ANN). The article uses methods of scientometric, epistemological and comparative analysis of the processes of ANN penetration into economics and other academic disciplines. The authors reveal the epistemological commonality and difference between AI and ANN and justify the shift in epistemological focus in research from general AI to ANN. The paper systematizes the use of ANN in economics: 1) ANN as a mathematical tool for solving economic problems; 2) ANN as a model of economic phenomena; 3) ANN as a methodology for understanding economic patterns. It shows the interaction of economics with neurosciences which occurs in two significantly different directions: from neurobiology, i.e. real nerve networks in living organisms, and, on the other hand, from ANN theory. The first direction is associated with neuroeconomics, the second has not yet been articulated, but shows an exponential growth in publications and is associated primarily with forming a new economic paradigm. The ANN paradigm in economics (and not only in economics) changes both the subject of cognition, introducing radically new forms/types of evidence and new research methods, and the object of cognition, changing the focus of study from individual economic behavior to the collective economic behavior of mega-subjects.
ANÁLISE DA RELEVÂNCIA DA INTELIGÊNCIA EMOCIONAL NO DESEMPENHO E CULTURA ORGANIZACIONAL DOS EMPREENDIMENTOS
Authors: Ascêncio Marcelo José , Preto Marcus Vinícius Gonçalves , Devechi Thais Nara Roberta , Galindo Leandro Cardoso , Roque Andreza Santoro , Maschio Patrícia Aparecida Scherite , Pereira Mário Henrique Marcondes , Macedo Karla Gonçalves
Published: September 2024

Esse estudo tem como finalidade demonstrar a relevância da habilidade conhecida como Inteligência Emocional - IE no desempenho e na cultura organizacional dos empreendimentos, como forma de construir e consolidar um ambiente corporativo mais produtivo, inovador, saudável e eficiente. Diante do exposto, diversos estudos e pesquisas analisam a eficácia da IE no ambiente corporativo, juntamente com uma cultura e clima organizacional que favoreça a aplicabilidade dessa habilidade. Esta pesquisa teve como objetivo analisar a relevância da IE no desempenho e cultura organizacional dos empreendimentos, especificamente identificar a integração da IE na cultura e desenvolvimento das empresas, bem como descrever estratégias eficazes para promover a IE nas organizações e demonstrar como a presença ou ausência de IE nos líderes e membros da equipe afetam a cultura organizacional e os resultados dos empreendimentos. A abordagem utilizada para o desenvolvimento da pesquisa foi à qualitativa, com revisão da literatura em livros de autores considerados relevantes e artigos publicados em periódicos reconhecidos, e ainda a abordagem quantitativa com a elaboração e aplicação de um questionário realizado no Google Forms. Por meio da base teórica analisada e os resultados do questionário foi possível perceber a importância do desenvolvimento e a aplicabilidade da IE no cenário organizacional através dos benefícios e resultados positivos obtidas pela mesma.
Soil Erosion Analysis with GIS: A Case Study of Oued Sly Catchment, Northern Algeria
Authors: Chaïeb Fatma , Abdelkader Bouderbala  , Abdelamir Saaed Hamoudi
Published: September 2024

Soil erosion is a process that involves the detachment and transportation of soil particles by water, presenting notable challenges of the depletion of soil fertility, diminished agricultural productivity, and consequences for water reservoirs. The integration of Geographic Information System (GIS) and modeling techniques provides a valuable platform for assessing and addressing soil water erosion. This study specifically examines the risk of soil water erosion in the Oued Sly catchment within the Middle Cheliff watershed in northern Algeria. Employing the Universal Soil Loss Equation (USLE) and thematic maps, the research evaluates the key factors influencing erosion. Results reveal that the catchment generally experiences low to moderate erosion levels, averaging 23.4 to 40 t ha-1 yr-1 across 90.7% of the total area. However, around 9.3% of the catchment exhibits higher erosion rates exceeding 40 t ha-1 yr-1. These findings offer valuable insights for informed watershed management and strategies to mitigate soil water erosion in comparable regions
Innovations in the comprehensive management of orofacial defects - Combined strategies of maxillofacial surgery, endodontics, orthodontics and Implants for the optimization of clinical results: A Narrative Review
Authors: Peralta Reyes Daniela Alejandra , Martínez Zambrano Cristian Patricio , Serrano Sánchez Jharen Alexander , Pilay Anchundia Doménica Dayanara
Published: September 2024

Orofacial defects caused by congenital anomalies, trauma, or surgical procedures present complex challenges that affect physical function and psychological well-being. Maxillofacial rehabilitation, incorporating surgery, endodontics, orthodontics, and implants, aims to restore form, function, and aesthetics. This review evaluates innovative multidisciplinary strategies for orofacial defect management. A narrative review was conducted using PubMed and Google Scholar databases. Search terms included "management of orofacial defects," "maxillofacial surgery," "endodontics in complex cases," "orthodontics in facial surgery," and "dental implants." Articles published between 2014 and 2024 were reviewed, focusing on human studies demonstrating integrated treatment strategies. The interdisciplinary approach to managing orofacial defects, integrating maxillofacial surgery, endodontics, orthodontics, and implants, has demonstrated significant improvements in both functional and aesthetic outcomes. Combined surgical techniques, such as the use of iliac and fibula grafts, offer enhanced graft success through improved vascularization. Technological advancements in endodontics, including CBCT and regenerative procedures, optimize treatment precision. Orthodontic innovations, like clear aligners and mini-implants, enhance patient comfort and treatment efficiency, while digital implant planning reduces complications. The incorporation of growth factors, bioactive materials, and AI further boosts clinical success in treating complex orofacial defects.
Quercetin diminishes the apoptotic pathway of magnetite nanoparticles in rats' ovary: Antioxidant status and hormonal profiles
Authors: Eleyan Mohammed , Ibrahim Khairy A. , Mohamed Rania A. , Hussien Mohamed , Zughbur Mohammed R. , Aldalou Ayoub R. , Masad Atef , El-Rahman Heba Ali Abd , Abdelgaid Hala A.
Published: September 2024

Magnetite nanoparticles have attracted the attention of researchers for biomedical uses, but their impacts on the reproductive system did not report. Here, we have studied the possible attenuation efficiency of quercetin against magnetite nanoparticles-induced apoptosis in ovarian. Forty female rats were divided equally into control, quercetin (100 mg/kg), magnetite nanoparticles (50 mg/kg), and magnetite nanoparticles+quercetin, where all rats received their doses for four weeks. Compared with the control, magnetite nanoparticles significantly reduced the serum hormonal levels (follicle-stimulating hormone, luteinizing hormone, estrogen, and progesterone) along with glutathione and superoxide dismutase in ovarian tissues. Moreover, magnetite nanoparticles markedly increased the ovarian malondialdehyde, and apoptotic gene expressions (Bax and caspase-3), and induced many histopathological changes. Significantly, co-treatment with quercetin markedly alleviated the hormonal profile, antioxidant disturbance, and ovarian apoptotic pathway of magnetite nanoparticles. Furthermore, our docking study revealed that quercetin could act as a caspase-3 inhibitor and allosteric agonist to follicle-stimulating hormone (Met520 and Val53), luteinizing hormone (Met517, Ala589, Ser604, and Lys595), estrogen (Met421, Phe425, and Ala350), and progesterone (Met759 and Met909) receptors. Those records reveal that the antioxidants and antiapoptotic characteristics are acceptable pointers for female infertility defenders of quercetin, especially during nanoparticle exposure.
Nefrectomia em cão: Relato de caso
Authors: Lima Camilla Mércia Almeida , Rodrigues Jaqueline , Da Silva Milene Costa , Marques Aiala Rocha , Dos Santos Jainara Rodrigues , Dos Anjos Laura Xavier , Vitória João Paulo , Gomes Junior Deusdete Conceição
Published: September 2024

A nefrectomia é a remoção cirúrgica do rim, podendo ser total, parcial ou radical. Dessa forma o presente trabalho objetivou relatar um caso de nefrectomia total em um cão SRD, portador de cisto renal. Foi atendido no (HVU-UFOB), um cão, macho, sem raça definida, 12 anos e 4 meses de idade, pesando 23,400 kg, castrado. Durante a anamnese, a tutora relatou que o animal apresentava um tumor na base do pênis, ao exame físico os parâmetros fisiológicos apresentavam-se normais. No exame físico específico foi palpado nódulo firme, na região lateral esquerda da base do pênis. Os exames complementares solicitados foram hemograma, perfil bioquímico, citologia do nódulo e ultrassom abdominal.  O hemograma e o bioquímico não apresentaram alterações, na citologia evidenciou-se quantidade elevada de células redondas, na ultrassonografia abdominal notou-se alteração no rim direito, com contorno irregular, perda da definição da arquitetura e dos limites córtico-medular devido a presença de estrutura cística com diâmetro médio de 8,68 cm, diante dos achados o diagnóstico sugestivo definido de cisto renal, optou por realizar a nefrectomia do rim direito. Para realizar a cirurgia foi solicitado hemograma e perfil bioquímico. O hemograma não revelou alterações. Dessa forma, conclui-se que a nefrectomia do rim direito para tratamento do cisto renal demonstrou-se como uma conduta eficaz e benéfica, sem sinais de recidiva.
Surgical Complications and Management Strategies in Endoscopic Endonasal Transsphenoidal Surgery for Pediatric Craniopharyngiomas
Authors: Gong Yang , Yang Gang
Published: September 2024

Endoscopic endonasal transsphenoidal surgery (EETS) has emerged as an effective method for the resection of craniopharyngiomas in pediatric patients, offering minimally invasive access and enhanced visualization. This literature review examines the surgical complications and management strategies associated with EETS for pediatric craniopharyngiomas. Common complications include cerebrospinal fluid (CSF) leaks, intraoperative hemorrhage, hypopituitarism, and visual disturbances. The incidence of these complications is influenced by factors such as tumor size and location, patient age, comorbidities, and surgeon experience. Effective management strategies involve meticulous preoperative planning, advanced imaging techniques, intraoperative monitoring, and comprehensive postoperative care. Detailed preoperative imaging is crucial for surgical planning, while intraoperative neuronavigation and neurophysiological monitoring help mitigate risks. Postoperative care, including endocrine evaluation and rehabilitation, is essential for addressing complications and improving patient outcomes. This review underscores the critical aspects of managing surgical complications to enhance the safety and efficacy of EETS in treating pediatric craniopharyngiomas.
The Pathways to Nurturing Children’s Growth Mindset in Family Education
Authors: Liu Lin , Liu Yong , Wang Lei , Gao Chenghai , Wang Tao
Published: September 2024

In family education, both parents and children have a belief system to construct the world and interpret experience. Some of these beliefs point to a dynamic self and a dynamic world with the possibility of growth, while others point to a static self and world with fixed qualities. These beliefs are part of the motivational system and strongly influence what goals people pursue. The cultivation of children’s growth mindset in family education can help children construct their desired life and study and maintain flexibility. No matter whether things are fulfilled or not, it will inject enthusiastic attempts and efforts into children’s life and study. These attempts and efforts can help children live a determined life, solve problems actively and discover their potential.
Reflect on the Impact of Music in the New Era
Authors: Wan Liyun
Published: September 2024

In the context of the rapid progress of the times, music is in a continuous state of evolution and innovation. The music of the new era, with its unique style and vivid expression, has exerted a profound and far-reaching impact on our lives. This paper conducts in-depth reflection on the influence of music in the new era on personal emotions, social culture, and artistic development. By analyzing the characteristics and development trends of music in the new era, it delves into its positive role in fulfilling people’s emotional needs, promoting cultural exchanges, and driving artistic innovation. At the same time, it also examines the potential issues such as excessive commercialization and aesthetic simplification. Finally, it puts forward prospects for the future development of music in the new era, emphasizing that while maintaining innovation, we should attach great importance to the diversity and rich cultural connotation of music to ensure its sustainable and healthy development.
Medical Treatment of Graves’ Disease: Benzylthiouracil vs. Methimazole, What to Choose?
Authors: Yosra Hasni , Chermitti Sondes , Maissa Thabet , Hamza El Fkih , Wiem Saafi , HALLOUL Imen , Ghada Saad , Wided Debbabi
Published: September 2024

Introduction: The management of Graves’ disease (GD) typically involves the use of synthetic antithyroid drugs (ATDs), primarily Methimazole (MMI) and Carbimazole (BTU), which aim to inhibit thyroid hormone synthesis and restore normal thyroid function. There are uncertainties regarding the choice of the most appropriate synthetic antithyroid drug (ATD) for the treatment of hyperthyroidism related to GD. This study aims to evaluate the efficacy and tolerance of MMI compared to BTU in patients diagnosed with GD. Patients and Methods: This cross-sectional analytical study included 121 patients diagnosed with GD. The patients were divided into two groups: Group 1 (G1, n=77), consisting of patients treated with Carbimazole (BTU), and Group 2 (G2, n=44), consisting of patients treated with Methimazole (MMI). We compared the efficacy and tolerance of the two drugs. Results: Adverse effects (AE) related to the ATDs were more frequent with MMI (18.2%) than with BTU (10.4%), but without a significant difference. The decrease in fT4 levels was significantly earlier and more pronounced with MMI compared to BTU. After a standard treatment duration (12 to 18 months), the remission rate was significantly higher with MMI than with BTU (58.3% vs. 31.9%; p=0.012). The relapse rate was comparable between the two groups (14.5% in G1 vs. 11.1% in G2; p=0.76). Conclusion: MMI is more effective than BTU in reducing fT4 levels and achieving remission in GD after a standard treatment duration. However, its contribution to the occurrence of adverse effects warrants further investigation.
Empowering Learners Through Entrepreneurial Skills in Senior Secondary Schools in Botswana
Authors: Dinama Baamphatlha , Kelebemang Tsietso , Olesitse Gaone Vivian
Published: September 2024

This study examined how teachers of business subjects empower learners for entrepreneurial mindset through integrated entrepreneurship education. This endeavor is a major engine for economic growth, job creation, upgrading of new technology increased productivity as well as changing various economic benchmarks which enable development within the economy. For this reason, learners need to be empowered through entrepreneurial skills. In this study, data were purposively collected through interviews and reviewing of documents. The study found out that business subject teachers cited self-employment as being one of the most important aspects for empowering their learners through entrepreneurial skills. Hence in their instruction, teachers familiarize learners with how a business is run, managed and marketed. However, the findings of the study indicate that, inadequate teaching skills of the subject matter and limited time allocated for business subjects seem to hinder teachers to further explore learner-centered methods like simulation, project based and case studies among others.
The Institutionalized Oppression of Reproductive Responsibility: A Dystopian Interpretation of the Maternal Role in The Handmaid’s Tale
Authors: E. Ç. Öykü
Published: September 2024

This paper examines the institutionalized oppression of women through the manipulation of reproductive responsibility in Margaret Atwood’s The Handmaid’s Tale. It explores how the dystopian regime of Gilead weaponizes the maternal role by reducing women to their reproductive capacities, employing surveillance, commodification, and religious manipulation to control their bodies and identities. The analysis delves into the mechanisms by which the state sustains its patriarchal power, such as ritualized sexual violence, forced surrogacy, and the distortion of Biblical narratives, to justify its exploitation of women. The paper investigates acts of resistance and reclamation of autonomy by the female characters, revealing how small acts of defiance and solidarity challenge Gilead’s oppressive structures. Atwood’s narrative is argued to be a critique not only of the fictional society but also of contemporary real-world issues surrounding reproductive rights, gender inequality, and bodily autonomy. Ultimately, the novel serves as both a warning against the erosion of rights and a call to resist patriarchal systems that seek to control and commodify women’s bodies.
Historical Analysis of Climate Variability and Agricultural Production in Nigeria (1931-2020)
Authors: Budnukaeku Alexander Chinago , Emmanuel Ojule Soldier
Published: September 2024

This study investigates the historical dynamics of climate variability and its impacts on agricultural production in Nigeria from 1931 to 2020. Utilizing a robust analytical framework that integrates climatic data analysis, statistical modelling, and geographic information system (GIS) techniques, the research explores trends in temperature and precipitation across different agro-ecological zones. Key findings reveal a consistent upward trend in average annual temperatures, with more pronounced warming observed in northern Nigeria, notably the Sahelian zone. Concurrently, precipitation patterns exhibit regional disparities, characterized by increased rainfall in southern regions and variable patterns in the north, including periods of severe droughts during the 1970s and 1980s. Statistical analyses employing Mann-Kendall trend tests and regression models confirm significant temperature increases and varying precipitation trends, underscoring their direct impacts on agricultural productivity. The study highlights the sensitivity of crop yields to climatic factors, demonstrating that rising temperatures adversely affect staple crops such as maize, millet, and sorghum, while adequate precipitation plays a critical role in enhancing yields. Socio-economic factors, including disparities in resource access between northern and southern regions, influence farmers’ adaptive capacity and resilience to climate variability. Adaptation strategies adopted by Nigerian farmers, such as adjusted planting schedules, crop diversification, and irrigation practices, are explored within the context of socio-economic constraints and infrastructural limitations. Spatial analysis using GIS provides insights into the differential impacts of climate variability across Nigeria, emphasizing the vulnerability of northern regions to climate shocks compared to the relative resilience of southern regions. Policy implications underscore the urgency of promoting climate-resilient agricultural practices, improving resource access, enhancing rural infrastructure, and implementing targeted capacity-building initiatives. These measures are essential for enhancing adaptive capacity, resilience, and sustainable agricultural development amidst on going climate variability and change in Nigeria.
Situation Analysis of Midea Company
Authors: Shen Yuhang
Published: September 2024

Midea Group, one of the famous companies in China, is known for its outstanding achievements in the field of household appliance. Under the guidance of diversification strategy, it has successfully occupied a broad market share and shown remarkable growth potential. Looking into the future, with the in-depth development of global economic integration and the continuous progress of science and technology, Midea will continue to adhere to the innovation-led development, constantly promote the upgrading of products and services, and is committed to building the world’s leading provider of household appliances and intelligent solutions. This article is aimed to conduct a comprehensive situation analysis of Midea. In this article, the overall information of Midea will be displayed, including its ownership structure, vision, mission, and core values, etc., so that readers can have a detailed understanding of the company. In addition, Midea’s product analysis, industry and market analysis will be performed, so that its marketing situation and competitive advantages can be further analyzed. Finally, two critical success factors of Midea will be listed to identify the reasons for its current success and strong market share. Also, in order to ensure its future performance growth, industry-related concerns and market-related concerns will also be discussed to analyze some potential risks and strong competitors.
Harmonizing Spaces: Investigating the Intersection of Sound and Architectural Design
Authors: Ajiboye Samson A.
Published: September 2024

The study titled “The Acoustic Design of Architectural Space: Exploring the Relationship between Sound and Building Design” investigates the intricate interplay between architectural form and acoustic performance. This research highlights the critical role of sound in shaping the functionality, aesthetics, and human experience of built environments. By examining the principles of architectural acoustics, the study delves into how sound interacts with architectural elements such as materials, geometry, and spatial configurations. The research emphasizes the importance of achieving a balance between technical acoustic performance metrics and subjective perceptual qualities, including ambiance and emotional resonance. The study underscores the necessity of interdisciplinary collaboration among architects, acousticians, engineers, and other stakeholders to address complex acoustic challenges and optimize the acoustic environment of architectural spaces. It explores the impact of acoustic design on various types of environments, including educational settings, healthcare facilities, workplaces, and urban areas. The findings reveal that poor acoustics can significantly affect learning outcomes, patient recovery, employee productivity, and overall well-being. Through comprehensive guidelines, standards, and best practices, the study advocates for the integration of acoustic considerations into architectural design and urban planning. It also highlights the potential of sustainable acoustic solutions and community engagement in creating inclusive and culturally sensitive environments. By adopting a user-centred approach and conducting post-occupancy evaluations, designers can continuously refine and enhance the acoustic performance of architectural spaces. This research contributes to the field of architectural acoustics by providing insights into the importance of sound in building design and offering recommendations for future research, practice, and policy development. The study aims to inspire architects and designers to prioritize acoustic comfort and create environments that enrich human experiences.
Unraveling the Complexity: Psychiatric Diagnoses and Character Attributes
Authors: Shen Yihan
Published: September 2024

This paper explores the complex relationship between mental illness and character flaws, using the Lorena Bobbitt case as a starting point to challenge the notion that these two concepts are synonymous. By defining mental illness as a biological dysfunction and character flaws as maladaptive behaviors rooted in social contexts, this essay distinguishes between the two. It examines their causes, diagnostic methods, treatments, and implications in the legal system. The analysis highlights the importance of differentiating between mental illness and character flaws to ensure fair treatment and effective intervention within both clinical and legal frameworks.
Residential Instability and Children’s Mental Health: Emotional and Behavioral Consequences of Frequent Relocation
Authors: Rodriguez-Perez C. J. , Castellanos X. L.
Published: September 2024

Residential instability, characterized by frequent relocations, poses significant risks to children’s mental health, impacting their emotional and behavioral development. This study explores the emotional and behavioral consequences of frequent relocations on children aged 5 to 15, using a mixed-methods approach that combines longitudinal quantitative data and qualitative interviews. The findings reveal that children who experience three or more relocations within five years exhibit significantly higher levels of anxiety, depression, and attachment issues, alongside increased externalizing behaviors such as aggression and defiance and internalizing behaviors such as social withdrawal and anxiety. Academic performance also suffers, with lower average scores in core subjects like mathematics and reading observed among frequently relocated children. These outcomes are moderated by factors such as parental support, community integration, and economic stability, highlighting the complex interplay between individual, familial, and contextual variables. The study underscores the need for targeted interventions and supportive policies to mitigate the negative impacts of residential instability and promote children’s mental health and well-being. Future research should focus on the long-term effects, specific vulnerable populations, and protective factors to better understand and address the challenges faced by children in unstable housing situations.
The Relationship Between Exercise Frequency and Cognitive Flexibility in Anxiety Disorder Patients Undergoing Combined Exercise and Cognitive Behavioral Therapy
Authors: Mägi Riho M. , Võrk Anu H.
Published: September 2024

This study investigates the relationship between exercise frequency and cognitive flexibility in patients with anxiety disorders undergoing combined Cognitive Behavioral Therapy (CBT) and exercise interventions. A longitudinal follow-up design was employed, with 80 participants randomized into four groups: low-frequency exercise, moderate-frequency exercise, high-frequency exercise, and a control group receiving CBT without exercise. Cognitive flexibility was assessed using the Wisconsin Card Sorting Test (WCST), and anxiety levels were measured by the Hamilton Anxiety Rating Scale (HAM-A) at baseline, post-intervention, and during 3-month and 6-month follow-ups. Results demonstrated a significant dose-response relationship, with higher exercise frequencies leading to greater improvements in cognitive flexibility and reductions in anxiety symptoms. The high-frequency exercise group exhibited the most substantial and sustained cognitive and emotional benefits, suggesting the importance of frequent exercise in enhancing and maintaining therapeutic outcomes in anxiety disorder treatment. These findings have critical implications for optimizing treatment strategies that integrate physical exercise with CBT to improve cognitive and emotional health in anxiety disorder patients.
The Influence of Digital Economy Development on the Income of Micro, Small, and Medium Enterprises in East Alok District
Authors: Pana Kristianus , Mitan Wilhelmina , Lamawitak Paulus Libu
Published: September 2024

This study aims to determine the influence of digital economy development on the income of Micro, Small, and Medium Enterprises in East Alok District, Sikka Regency. This research explores data sourced from Micro, Small, and Medium Enterprises (MSMEs) in Sikka Regency because Sikka Regency has many office facilities, schools, and shops, and is a center for culinary tourism in East Alok District. In this research, the author uses quantitative research. The population in this study is MSMEs in East Alok District, Sikka Regency which totals 1,548 MSMEs. In this study, the size of the sample was determined using the Slovin formula so that the number of samples to be used as samples in this study was 94 MSME Units. The purposive sampling technique is used to determine the type of sample to be used in this study. The results of the study show that the Digital Economy affects the income of MSME actors in Alok District, Sikka Regency. By leveraging digital technology, individuals and organizations can improve efficiency, reach more customers, and develop new, sustainable revenue streams.
Nexus Between Body Image Perception, BMI, and Self-Esteem Among Indian Young Adults: A Quantitative Analysis
Authors: Vankrothu Chaitanya , Gummadi Rani Vidhyulatha , Swapna B  , Yarram Vasavi
Published: September 2024

This study investigates the relationship between BMI, self-esteem and body image perceptions among young adults in India, with a focus on gender differences. Using a crosssectional correlational methodology, data were collected from 101 participants from undergraduate University students in Andhra Pradesh, employing the “Multidimensional Body-Self Relations Questionnaire” (MBSRQ) and the “Rosenberg Self-Esteem Scale” (RSES). Descriptive statistics, correlational analysis, and regression analysis were used to examine the variables' associations. The results revealed a positive correlation between BMI and body image perceptions, particularly in subscales of Fitness Evaluation and SelfClassified Weight. However, the overall relationship between self-esteem and body image was weak, suggesting a limited impact of body image on self-esteem in this population. The regression model explained 13% of the variance in self-esteem, with Fitness Orientation emerging as a significant predictor. Contrary to expectations, there were no significant gender differences found in self-esteem or body image satisfaction. These findings highlight the influence of societal shifts towards body positivity and inclusivity in reducing the impact of body image concerns on self-esteem. The study underscores the need for promoting physical fitness and challenging traditional beauty standards to foster self-acceptance and well-being among Indian young adults.
XÂY DỰNG VÀ THẨM ĐỊNH PHƯƠNG PHÁP ĐỊNH LƯỢNG QUERCETIN TRONG CÂY TRAI HOA TRẦN (MURDANNIA NUDIFLORA (L) BRENAN) BẰNG SẮC KÝ LỎNG HIỆU NĂNG CAO
Authors: Nguyễn Văn Khởi , Trần Thị Phượng , Lê Việt Hải , Vũ Đức Lợi , Lê Hồng Dương , Chử Đức Thành , Nguyễn Thị Thanh Hằng , Chử Văn Mến
Published: September 2024

Mục tiêu: Xây dựng và thẩm định phương pháp định lượng Quercetin trong cây trai hoa trần (Murdannia nudiflora (L.) Brenan.) bằng phương pháp sắc ký lỏng hiệu năng cao (High-performance liquid chromatography - HPLC). Phương pháp nghiên cứu: Khảo sát, lựa chọn điều kiện sắc ký tối ưu, thẩm định theo hướng dẫn của Ủy ban Quốc tế về đồng bộ hóa yêu cầu kỹ thuật phân tích cho dược phẩm dùng trên người (International Conference on Harmonization - ICH) trên các tiêu chí về độ đặc hiệu, độ lặp lại, tuyến tính, độ đúng và độ chính xác. Kết quả: Xác định được các điều kiện sắc ký gồm cột Optimapak C18 (250mm x 4,6mm; 5µm), pha động MeOH - acid formic 0,2% (30:70), tốc độ pha động 0,7 mL/phút, thể tích bơm mẫu là 20μL và bước sóng phát hiện là 370nm. Kết quả thẩm định cho thấy phương pháp có độ đặc hiệu, độ chính xác, độ đúng cao, giới hạn định lượng thấp, đáp ứng yêu cầu về độ tuyến tính. Kết quả định lượng cho thấy hàm lượng Quercetin trong cây trai hoa trần là 15,29 ± 0,18 mg/g. Kết luận: Nghiên cứu đã xây dựng được phương pháp HPLC để định lượng Quercetin trong cây trai hoa trần.
KẾT QUẢ PHẪU THUẬT ĐIỀU TRỊ BÀN CHÂN BẸT Ở NGƯỜI TRƯỞNG THÀNH
Authors: Vũ Nhất Định , Phạm Ngọc Thắng Phạm Ngọc Thắng , Nguyễn Tiến Thành Nguyễn Tiến Thành , Vũ Anh Dũng Anh Dũng
Published: September 2024

Mục tiêu: Mô tả đặc điểm lâm sàng, hình ảnh X-quang và kết quả phẫu thuật điều trị cho nhóm bệnh nhân (BN) bị bàn chân bẹt được phẫu thuật theo phương pháp Evans. Phương pháp nghiên cứu: Nghiên cứu hồi cứu trên 20 trường hợp với 22 bàn chân bẹt được phẫu thuật tại Bệnh viện Quân y 103 từ tháng 01/2018 - 01/2022. Kết quả: BN ở độ tuổi 21 - 41, đau ở bờ trong bàn chân, mất vòm gan chân, trong đó, đau là nguyên nhân chính khiến BN đến khám và chấp nhận phẫu thuật. Diện tỳ gan chân rộng ≥ diện tỳ của 1/2 trước gan chân, bờ trong bàn chân lồi vào trong, góc xương sên - xương bàn I lớn (15 - 35°), độ dốc của xương gót nhỏ (3 - 10°). Kết quả phẫu thuật: 1/22 bàn chân bị toác vết mổ. Tình trạng đau và góc xương sên - xương bàn I được cải thiện rõ rệt (từ 15 - 35° xuống còn 0 - 10°), độ dốc của xương gót cải thiện từ 3 - 10° lên 15 - 28°. Kết luận: Nhóm BN có đặc điểm đau ở bờ trong bàn chân, mất vòm gan chân, diện tỳ gan chân ≥ diện tỳ của 1/2 trước gan chân, bờ trong bàn chân lồi vào trong, góc xương sên - xương bàn I lớn, độ dốc của xương gót nhỏ; kết quả phẫu thuật cải thiện góc xương sên - xương bàn I, độ dốc của xương gót và chức năng của bàn chân.