bluuebunny/crossref_metadata_2025 huggingface dataset:
Land Slide Causes and Rehabilation Measures
Authors: Behera Sumant Kumar , Sahoo Chitrabhanu
Published: July 2023

Abstract: The potential for loss of life and destruction of assets through landslides is increasing in many mountainous and hilly areas of Asia. Logging, residential and infrastructure development and other activities continue to expand on slopes highly prone to landslides. Excessive soil water content is the primary cause of slope failure while steep slopes, weak soils or topography that concentrates water are the main factors contributing to landslide risk. Poorly constructed roads and the loss of soil reinforcement and water extraction by tree roots increases the probability of landslides during trigger events such as prolonged heavy rainfall or earthquakes. Climate change predictions suggest that landslide frequency will increase in some areas of Asia as the frequency of extreme storms increases. Drought may also affect some areas resulting in root dieback, pest and disease outbreaks and wildfire - all of which are likely to reduce soil reinforcement provided by trees and increase landslide incidence. Scientific studies confirm the crucial role of trees and forests in preventing shallow landslides, not only by reinforcing and drying soils but also in directly obstructing smaller slides and rock falls. The role of trees and forests in relation to deepseated landslides is considerably smaller although soil drying by tree roots can still help to avoid excessive soil water pressures. During extreme events, involving heavy rainfall, very weak slopes or seismic activity, forest cover is unlikely to have any effect. Policies encouraging land uses that reduce soil disturbance and retain a high degree of forest cover can, however, reduce landslide risk. Tree planting on susceptible slopes can also reduce risk while natural regeneration and tree planting on failed slopes can help to control the after-effects of landslides such sediment release into rivers. Fast growing trees and shrubs are best suited to this purpose but socio-economic and conservation-related factors should also be considered. Above all, identifying and mapping high landslide risk zones and avoiding activity within these areas is an essential step in reducing the risk to lives and assets posed by landslides.
Public Perception of Electronic Waste as an Increase in Environmental Awareness
Authors: Soelistianto Farida Arinie , Marjono Marjono , Siwindarto Ponco , Yanuwiadi Bagyo
Published: July 2023

bstract: Electronic waste management has been a problem for a quite long time. Referring to Government Regulation No. 27 of 2020, it is important to provide education on the management of electronic waste generated by households. Specific waste is classified as B3 waste which requires special management. This study focuses on the management of electronic waste generated by households in Malang City. The flow of waste from households was measured from the disposal, repair, or donation process using questionnaires and interviews. This study involved electronic waste collectors participating in the survey on electronic waste collection. Demographically, educational background and household income do not influence the reduction of electronic waste accumulation by the type of waste disposed of and the treatment.
Localization of Disease Osteoporosis in X-ray Images
Authors: Bhadouria Aashi Singh , Bhadouria Ishan Singh , Patel Vanshika , Upasani Akshat
Published: July 2023

Abstract: People with osteoporosis are more likely to break bones, particularly in the wrist, hip, and spine. Determining the existence of osteoporosis requires measurements of bone quantity and quality, especially bone mineral density (BMD). Science may use many techniques in order to ascertain the BMD. Dual Energy X-ray Absorptiometry (DEXA) is one of the procedures that has gained the most widespread acceptance. The T-score is a method that uses bone mineral density to quantify the degree to which osteoporosis has progressed (BMD). The BMD assessment may be seen on X-ray or DEXA images. Bone mineral density (also known as BMD) is tested in order to make a diagnosis of osteoporosis. This article offers an overview of many popular image-processing methods used in BMD assessment. These methods include image augmentation, segmentation, and texture analysis. Due to its many advantages, DEXA is finding a wide variety of new applications in medicine and science. At the end of the piece, we take a quick look at the first techniques for determining BMD. Similarities between DEXA and X-ray images are also highlighted in the article. The methods of image processing that may be used to detect osteoporosis are detailed in the article. Methods for preparing X-ray and DEXA pictures for analysis, extracting features from those images, and segmenting them are described.
The Effects of IoT after COVID-19 on the Modern Healthcare Industry
Authors: Bhadouria Aashi Singh , Patel Vanshika , Bhadouria Ishan Singh , Upasani Akshat
Published: July 2023

Abstract: In the last several years, IoT applications in the healthcare sector have skyrocketed (IoT). The major goal of IoT is to provide people with the basics they need to survive in these uncertain times. The availability of IoT-based healthcare solutions is critical during this pandemic. The IoT allows for more precise diagnosis, better treatment, and closer monitoring of patients. IoT technology can fundamentally overhaul the present system, and academics have been working around the clock since the beginning of the pandemic to discover answers. By the time this report was completed, about 6 million individuals had lost their lives to the COVID-19 pandemic. Many lives may have been avoided. People can't call an ambulance, can't locate one, and can't get to the hospital safely when they're too ill. People in extreme situations may instantly summon an ambulance or other emergency contacts by pressing a button on their phone or using a voice-enabled device. According to the findings, this might be a life-saving breakthrough if it is taken seriously by significant businesses.
EFEK EKSTRAK ETANOL DAUN JARAK PAGAR (Jatropha curcas L.) TERHADAP KADAR TRIGLISERIDA PADA TIKUS HIPERTENSI YANG DIBERI PAKAN LEMAK TINGGI
Authors: Saiful Bachri Moch. , Yuli  Anita Wiki , Yuliani Sapto , Widyaningsih Wahyu , Sofia Vivi , Estiningsih Daru
Published: July 2023

Daun jarak pagar (Jatropha curcas L.) mengandung beberapa senyawa aktif, seperti alkaloid, saponin, tannin, terpenoid, steroid, glikosida, senyawa fenol, dan flavonoid yang diduga dapat menurunkan kadar trigliserida dalam serum darah, sehingga dapat mencegah keadaan hipertrigliseridemia. Penelitian ini bertujuan untuk mengetahui aktivitas penurunan kadar trigliserida serum setelah pemberian ekstrak etanol daun jarak pagar (EEDJP) variasi dosis pada tikus hipertensi yang diinduksi dengan NaCl dan diberi pakan lemak tinggi.
Penelitian eksperimental dengan pre-post test control group design terhadap tikus jantan galur Wistar. Tikus dibagi menjadi 7 kelompok, yaitu kelompok normal, kontrol, Captopril, Simvastatin, EEDJP dosis 1,8 g/KgBB, 2,7 g/KgBB, 4,05 g/KgBB. Analisis kadar trigliserida serum dengan metode GPO- PAP. Data dianalisis   dengan uji One-Sample Kolmogorov- Smirnov Test, Homogenity of Variances, One-Way ANOVA, Kruskal-Wallis, dan Mann-Whitney.
Induksi NaCl dan pemberian pakan lemak tinggi dapat meningkatkan kadar trigliserida serum yang signifikan (p<0,050). Pemberian EEDJP dapat menurunkan kadar trigliserida serum yang signifikan (p<0,050) pada semua variasi dosis .Kesimpulannya EEDJP dapat menurunkan kadar trigliserida secara signifikan pada dosis 1,8 g/KgBB, 2,7 g/KgBB, 4,05 g/KgBB
The Addition Effect Of Active Carbon From Waste of Ambon Lumut Banana Peel ( Musa acuminata Colla) on Decreasing Peroxide in Used Cooking Oil
Authors: Lubis Novriyanti , Pangestika Esty Rahayu , Soni Dang
Published: July 2023

High temperature, repeated, and oxidized heating process will experience used cooking oil damage. Peroxide number is the most important value to determine the degree of damage the oil. The purpose of this study was to see the effect of soaking with activated carbon from Ambon Lumut banana peels with different activators on decreasing the peroxide value in used cooking oil, determining the analysis was carried out using the iodometric method. The results were obtained after soaking banana peel activated carbon with HCl activator in used cooking oil samples from frying chicken, fried snacks, and 2 times the use of each % decreased peroxide number by 82.26%; 30.90% and 68.88%, while the ZnCl2 activator in these samples decreased by 85.22%; 51.82% and 92.77%. The use of ZnCl2 activator gives the best results in reducing the peroxide value in used cooking oil.
Pasta Gigi Ekstrak Daun Beluntas (Pluchea indica L.) Sebagai Antibakteri
Authors: Wahyuningsih Sri , Ndaso Ivon Sensiana , Ndaso Ivon Sensiana , Aliah Ahmad Irsyad
Published: July 2023

Beragam mikroorganisme dapat ditemukan dan hidup dalam rongga mulut, salah satunya Streptococcus mutans yang dapat menyebabkan karies gigi. Daun beluntas (Pluchea indica L.) mempunyai banyak kandungan senyawa aktif seperti flavonoid yang memiliki aktivitas terhadap bakteri gram positif yang mampu dimanfaatkan untuk mengatasi masalah kesehatan pada rongga mulut terutama gigi seperti bakteri Streptococcus mutans. Salah satu pencegahan terjadinya karies gigi dengan penggunaan pasta gigi secara teratur. Penelitian ini bertujuan untuk memformulasi pasta gigi dari daun beluntas dan mengetahui aktivitasnya sebagai antibakteri. Daun beluntas (Pluchea indica L.) dimaserasi menggunakan pelarut etanol 96% kemudian ekstrak etanol daun beluntas (EEDB) diformulasikan menjadi pasta gigi dengan masing-masing konsentrasi 5% (F1), 7,5% (F2); dan 10% (F3) dan diuji aktivitas antibakteri terhadap Streptococcus mutans. Hasil penelitian formula pasta gigi menunjukkan tidak terjadi perubahan sebelum dan setelah uji cyling test untuk kestabilan formula pasta gigi. Uji aktivitas pasta gigi EEDB yang diukur dengan jangka sorong menunjukkan konsentrasi 10% (F3) memiliki diameter zona hambat 21,77±0,49 mm mendekati zona hambat pasta gigi merk ‘X’ sebagai pembanding dengan zona hambat 22,00±1,32 mm yang termasuk kategori sangat kuat sebagai antibakteri terhadap Streptococcus mutans dengan nilai signifikansi p=1,000 (p>0,05).
Farmakoterapi Pasien Hiperkolesterolemia Familial: Suatu Tinjauan Narasi
Authors: Purwowiyoto Sidhi Laksono , Afiyani Nadia
Published: July 2023

Hiperkolesterolemia familial (FH) merupakan kelainan autosomal dominan yang ditandai dengan kadar low-density lipoprotein kolesterol (LDL-C) yang tinggi pada plasma. Bahaya resiko kejadian kardiovaskular dan tingginya angka prevalensi menjadikan hiperkolesterolemia familial beban penyakit yang harus segera ditangani. Modifikasi gaya hidup memang  merupakan tatalaksana awal namun banyak dari pasien FH membutuhkan terapi farmakologis  untuk menurunkan kadar LDL-C dalam plasma. Hingga saat ini, terdapat banyak terapi dislipidemia yang tersedia dengan berbagai target terapi. Statin tetap menjadi yang paling popular dan pilihan utama pada rekomendasi-rekomendasi yang ada. Meskipun begitu, pada pasien intoleransi statin, terdapat banyak pula pilihan pengobatan yang dinilai cukup efektif untuk menurunkan kadar LDL-C, meskipun banyak juga diantaranya masih membutuhkan penelitian lebih lanjut dalam hal keamanan jangka panjang.
Analisis Permasalahan Terkait Obat Pada Pengobatan Pasien Asma Rawat Inap
Authors: Lorensia Amelia , Pratiwi Anindita Dyah
Published: July 2023

AAsma adalah penyakit yang ditandai dengan peradangan saluran napas yang mengakibatkan obstruksi saluran napas yang bersifat reversible. Penatalaksanaan asma bertujuan untuk meningkatkan dan mempertahankan kualitas hidup pasien agar pasien dapat menghilangkan dan mengendalikan gejala asma, pasien dapat mencegah eksaserbasi akut serta memelihara fungsi paru agar pasien tidak mengalami kematian karena asma. Tujuan penelitian ini adalah untuk mengetahui masalah terkait obat (MTO) dan terapi yang paling banyak terlibat pada kejadian MTO pada pasien asma yang menjalani rawat inap di suatu rumah sakit umum di Sidoarjo. Desain penelitian adalah retrospektif dengan menggunakan data rekam medik sampel asma pada tahun 2017-2018. Dari total 100 data rekam medik pasien, sebanyak 143 (97,28%) kasus terkait masalah obat saat pengobatan di IGD dan sebanyak 202 (98,06%) kasus terkait masalah obat saat menjalani rawat inap. Terapi yang paling banyak terlibat kejadian MTO adalah ceftriaxone dengan jumlah 86 (60,14%) kasus saat pengobatan di IGD dan saat menjalani rawat inap adalah ceftriaxone dengan jumlah kasus sebesar 112 (55,44%) kasus. Oleh karena itu pengobatan asma di rumah sakit harus mendapatkan perhatian agar dapat mencapai hasil yang optimal dalam efektifitas dan keamanan.
Review Tanaman Gaharu (Aquilaria malaccensis Lam.) Ditinjau Dari Segi Farmakognosi, Fitokimia, Dan Aktivitas Farmakologi
Authors: Za'amah Ulfah  , Prastiwi Rini , Hayati Hayati
Published: July 2023

Tanaman tanaman Gaharu (Aquilaria malaccensis Lam.) merupakan tanaman yang banyak digunakan dalam pengobatan, kosmetik dan aromaterapi. Kajian ini dilakukan untuk mengetahui cara mengidentifikasi dari segi farmakognosi, menentukan kandungan fitokimia, dan mengetahui berbagai aktivitas farmakologi yang terkandung dalam tanaman Gaharu. Pemeriksaan karakterisasi mutu ekstrak daun gaharu meliputi uji makroskopis, uji mikroskopis, penentuan kadar air. , kadar abu total, kadar abu tidak larut asam, kadar ekstrak larut air, kadar ekstrak larut etanol, dan susut pengeringan. Hasil dari studi literatur didapatkan data kadar air 4,32%, kadar sari larut air 12,09%, kadar sari larut etanol 9,56%, kadar abu total 7,78%, dan kadar abu tidak larut asam 0,62%. Kandungan senyawa dalam daun gaharu antara lain flavonoid, glikosida, tanin, dan triterpenoid. Tanaman gaharu memiliki beberapa aktivitas farmakologi seperti antibakteri, antidiabetes, antiinflamasi, anti rayap, dan antioksidan. Adanya kandungan senyawa metabolit sekunder ini membuat Gaharu mempunya aktivitas farmakologi.
Evaluasi Penggunaan Antibiotik Berdasarkan Tepat Obat Dan Tepat Dosis Pada Pasien Appendicitis Rawat Inap Di RSUD "X” Tahun 2018
Authors: Ramadhani Gusti Rizky Puspa , Difa Intannia , Jenah Rina Astiyani
Published: July 2023

Appendicitis merupakan salah satu penyakit abdomen akut karena adanya inflamasi atau infeksi bakteri pada apendiks vermiformis. Tujuan penelitian yaitu mendeskripsikan pola penggunaan antibiotik pada pasien appendicitis rawat inap dan mengevaluasi ketepatan penggunaan antibiotik (tepat obat dan tepat dosis) pada pasien appendicitis rawat inap di RSUD "X”. Desain penelitian ini observasional yang bersifat deskriptif dan pengambilan data secara retrospektif. Populasi penelitian adalah seluruh data rekam medis pasien dengan diagnosis appendicitis di RSUD "X” selama tahun 2018 dengan kriteria inklusi penelitian adalah rekam medis pasien yang mendapatkan antibiotik dan kriteria eksklusi adalah rekam medis tidak lengkap dan tidak ditemukan serta terapi antibiotik dihentikan karena pasien pulang paksa, meninggal <48 jam, dirujuk dan pindah. Data diievaluasi dengan menyesuaikan jenis obat dan diagnosis pasien yang tepat sesuai dengan drug of choice yang tertera di guideline IDSA, SIS, dan AMMI Canada. Hasil penelitian menunjukkan golongan dan jenis antibiotik yang paling banyak digunakan adalah terapi tunggal sefalosporin dengan jenis antibiotik ceftriaxone (50,98%) diikuti dengan kombinasi ceftriaxone-metronidazole (31,37%). Rute pemberian paling banyak digunakan yaitu intravena sebesar 98,04% dan durasi pemberian antibiotik paling banyak selama 4-6 hari sebesar 60,78%. Ketepatan penggunaan antibiotik berdasarkan tepat obat diperoleh 23,53%. Ketepatan penggunaan antibiotik berdasarkan tepat dosis diperoleh 64,71%.
Pengaruh Jenis Pelarut Ekstrak Kecambah Kacang Hijau (Vigna radiata L.) Terhadap Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 dan Jamur Candida albicans ATCC 01231
Authors: Larasati Niken Ayu , Indah Tri , Marpaung Mauritz Pandapotan , Purnama Purnama
Published: July 2023

Kecambah kacang hijau merupakan salah satu tanaman yang memiliki potensi sebagai antibakteri dan antijamur karena mengandung alkaloid, flavonoid, tanin, saponin, terpenoid/steroid. Penelitian ini bertujuan untuk menentukan efektivitas ekstrak kecambah kacang hijau sebagai antibakteri dan antijamur terhadap bakteri Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 dan jamur Candida albicans ATCC 01231 berdasarkan perbedaan jenis pelarut. Sampel yang digunakan dalam penelitian ini adalah kecambah. Metode ekstraksi yang digunakan adalah maserasi dengan pelarut etanol 96%, etil asetat, dan n-heksana. Pengujian daya hambat terhadap pertumbuhan bakteri dan jamur dilakukan dengan menggunakan metode difusi agar. Hasil penelitian menunjukkan ekstrak etanol paling efektif menghambat bakteri S.aureus, E.coli dan jamur C.albicans pada konsentrasi 100% dengan rerata daya hambat masing-masing sebesar 12,5±1,0 mm, 18±1,6 mm dan 18,2±1,7 mm dengan kategori kekuatan kuat. Ekstrak Etil Asetat efektif menghambat bakteri S.aureus, E.coli dan jamur C.albicans pada konsentrasi 100% dengan rerata daya hambat 8,5±1,0 mm, 14,8±2,4 mm dan 8,5±0,4 mm. Ekstrak n-heksana tidak memiliki aktivitas daya hambat terhadap bakteri S.aureus, E.coli dan jamur C.albicans. Ekstrak kecambah kacang hijau dalam pelarut etanol, etil asetat dan n-heksana tidak memiliki potensi daya hambat bakteri dan jamur untuk dikembangkan sebagai zat aktif antibakteri dan antijamur pada suatu sediaan farmasi atau obat.
Drug Review : Oksitosin dan Misoprostol Pada Postpartum Hemorrhage (PPH)
Authors: Aghnia Fuadatul Inayah  , Yulistiani Yulistiani , Ratnasari Ayu , Tyas Angganawati Rahmadhani , Sulistyono Agus
Published: July 2023

Postpartum Hemorrhage (PPH) merupakan penyebab yang sangat penting dari mortalitas dan morbiditas ibu di seluruh dunia. Seluruh pedoman merekomendasikan oksitosin intramuskular sebagai pengobatan uterotonik lini pertama untuk semua perempuan yang melahirkan pada persalinan trimester ketiga. Pengobatan ini untuk pencegahan PPH karena kemanjuran dan keamanannya, sementara misoprostol digunakan sebagai alternatif dalam kondisi di mana oksitosin tidak tersedia atau di daerah di mana pasien tidak memiliki akses ke perawatan yang terampil. Tujuan penelitian ini untuk membandingkan penggunaan oksitosin dan misoprostol berdasarkan dosis, dan aspek farmasi yang berupa bentuk sediaan, pemberian, stabilitas/penyimpanan dan efek samping umum yang terjadi pada pasien PPH. Studi ini merupakan narrative review yang dilakukan penelusuran pustaka melalui Google Scholar, Pubmed dan Science Direct. Hasil review menunjukkan profilaksis oksitosin mengurangi kehilangan darah dan kejadian PPH tanpa hasil yang merugikan. Penggunaan oksitosin dengan Uniject juga memberikan keuntungan pada penghematan biaya. Akan tetapi, penggunaan oksitosin harus diberikan oleh tenaga profesional. Pengunaan misoprostol adalah alternatif yang efektif untuk pengobatan PPH primer. Namun, penggunaan misoprostol dikaitkan dengan beberapa efek samping sehingga diberikan apabila ketersediaan oksitosin terbatas. Dengan demikian, dapat disimpulkan pemberian oksitosin lebih diutamakan untuk PPH karena dari efek samping lebih minimal dibandingkan misoprostol.
Studi Farmakognosi, Fitokimia Dan Aktivitas Farmakologi Tanaman Pepaya Jepang (Cnidoscolus aconitifolius (Mill.) I.M. Johnston)
Authors: Novita Sari Sartika , Prastiwi Rini , Hayati Hayati
Published: July 2023

Tanaman Pepaya Jepang (Cnidoscolus aconitifolius (Mill.) I.M. Johnston) merupakan tanaman dari suku Euphorbiaceae yang berasal dari Semenanjung Yucatan, Meksiko. Tanaman pepaya jepang digunakan sebagai obat tradisional dengan memanfaatkan bagian tanaman, antara lain daun dan batang. Tanaman pepaya jepang mengandung banyak metabolit sekunder yang saling bersinergis dalam memberikan efek farmakologis. Review ini bertujuan untuk memberikan informasi terkait kandungan senyawa aktif dan aktivitas farmakologis, dalam mengatasi berbagai penyakit. Berdasarkan beberapa penelitian diketahui tanaman pepaya jepang memiliki aktivitas farmakologis seperti antibakteri, antijamur, antioksidan, antidiabetes, hiperkolesterolemia, antiinflamasi, perbaikan pada kerusakan hati dan asam urat. Aktivitas farmakologis terjadi dengan berbagai mekanisme kerja dalam mengatasi berbagai penyakit. Senyawa kimia yang terkandung dalam pepaya jepang seperti saponin, flavonoid, tanin, alkaloid, fitat, glikosida sianogenik, dan terpenoid.
Tingkat Kepatuhan Penggunaan Obat Anti Tuberkulosis Paru di Rumah Sakit PKU Muhammadiyah Bantul Menggunakan Metode Pill-Count dan MARS
Authors: Afwansyah Miftahul , Dania Haafizah
Published: July 2023

Penyakit tuberkulosis menjadi salah satu kasus kematian tertinggi sehingga perlu perhatian khusus dalam upaya pencegahan dan penanggulangannya agar menghentikan penularan. Kepatuhan meminum obat merupakan faktor penting dalam keberhasilan pengobatan tuberculosis (TB), sehingga mengurangi resiko gagal pengobatan atau kuman mycobacterium resisten terhadap obat (Multi Drug Resistant Tuberculosis). Penelitian ini bertujuan untuk mengetahui gambaran tingkat kepatuhan pengobatan pasien TB di RS PKU Muhammadiyah Bantul. Penelitian ini menggunakan desain observasional deskriptif dengan studi cross-sectional. Metode yang dilakukan yaitu wawancara menggunakan kuesioner Medication Adherence Rating Scale (MARS) dan Pill-count, dengan kriteria inklusi yaitu Pasien TB Paru diagnosis ICD-10 kode A15.0, berusia >17 tahun, telah menjalani terapi OAT-kategori I minimal selama 1 bulan. Pasien dikatakan patuh pada berdasarkan metode pill count yaitu, sedangkan kepatuhan dengan metode MARS dibagi mejadi 3 kategori yaitu kategori tinggi jika skor 25, kategori sedang jika skor 6-24, kategori rendah jika skor â‰¤5. Hasil penelitian dari 30 subyek penelitian diketahui hasil pengukuran kepatuhan menggunakan metode Pill-Count diketahui 100% pasien patuh dan hasil pengukuran tingkat kepatuhan menggunakan metode MARS diketahui 77% pasien memiliki tingkat kepatuhan tinggi, 23% pasien memiliki tingkat kepatuhan sedang. Hasil penelitian dapat disimpulkan bahwa pasien tuberkulosis di RS PKU Muhammadiyah Bantul patuh, dengan tingkat kepatuhan tinggi dan sedang.
Standarisasi dan Analisis Ftir Ekstrak Etanol 70% Bulu Babi (Echinometra mathaei) dari Sabang, Nanggroe Aceh Darussalam
Authors: Kresnamurti Angelica , Izazi Farizah , Camelia Dina
Published: July 2023

Bulu Babi (Echinometra mathaei) atau landak laut dalam Bahasa Inggris disebut sea urchin memiliki kandungan senyawa bioaktif yang bersifat toksik. Penelitian ini bertujuan untuk menganalisis kandungan metabolit sekunder pada ekstrak etanol 70% Bulu Babi Echinometra mathaei dengan menggunakan analisis FTIR Tahapan penelitian meliputi determinasi, ekstraksi, uji organoleptis, uji makroskopis, dan analisis FTIR. Determinasi sampel menyimpulkan sampel yang digunakan adalah Bulu Babi Echinometra mathaei. Pengujian makroskopik didapatkan bentuk oval, warna hitam keunguan, bau khas bulu babi dan dimensi ukuran berdiameter ±4,5cm. Ekstraksi dengan metode maserasi menghasilkan rendemen 13,51%. Hasil uji organoleptis berupa ekstrak kental, cokelat kehitaman dan bau khas Bulu Babi. Hasil skrining fitokimia menunjukkan kandungan triterpenoid, flavonoid, alkaloid, saponin, dan tannin. Data hasil analisis cemaran ekstrak menunjukkan tdk ada cemaran mikroba, cemaran kapang/khamir, dan cemaran logam memenuhi persyaratan. Hasil analisis spektroskopi FTIR menunjukkan bahwa senyawa aktif mengandung gugus –OH yaitu alkohol (w 3744.203 dan 3339.768 cm-1), C=O yaitu keton pada cincin aromatis (w 1623.884 dan 1569.971cm-1), ikatan rangkap pada cincin aromatis -C=C (w 1404.716 cm-1), -CH3 ikatan tunggal C-H3 pada alcohol (w 1169.226 cm-1) dan =C-H (1000–650 cmâˆ’1) yaitu alkena. Kesimpulan penelitian ini adalah ekstrak etanol 70% Echinometra mathaei mengandung metabolit saponin, triterpenoid, flavonoid, alkaloid, tannin.
Lise Öğrencilerinde Spor Yapmanın Teknoloji Bağımlılığı, Okula Bağlılık Ve Akademik Erteleme Üzerindeki Rolü
Authors: ARSLAN Hayati , KUYULU İhsan , YALDIZ Ömer , BELTEKİN Enes
Published: July 2023

Bu araştırma lisanslı olarak spor yapan ve spor yapmayan öğrencilerinin teknoloji bağımlılığı, okula bağlılık ve akademik erteleme düzeylerinin incelenmesi amacıyla yapılmıştır. Araştırmanın örneklem gurubunu, 2022-2023 eğitim öğretim döneminde Diyarbakır ili Ergani ilçesi, Milli Eğitim bakanlığına bağlı liselerde öğrenim gören gönüllü 310 öğrenci oluşturmuştur. Veri toplama aracı olarak katılımcıların demografik bilgilerine ilişkin soruların yer aldığı form; Aydın (2017) tarafından geliştirilen teknoloji bağımlılığı ölçeği, Çakıcı (2003) tarafından geliştirilen akademik erteleme ölçeği ve Çengel, Totan ve Çöğme (2017) tarafında Türkçeye uyarlanan okula bağlılık ölçeği kullanılmıştır. Elde edilen veriler SPSS 22 paket programı kullanılarak analiz edilmiş ve anlamlılık derecesi 0.05 olarak belirlenmiştir. Verilerin normallik dağılımları test sonuçlarına göre, normal dağılım gösteren verilerin analizlerinde bağımsız değişkenlerin ikili karşılaştırmaları için T testi, çoklu karşılaştırmaları için ise Anova analizi yapılmıştır. Değişkenler arasında farklılık bulunması durumunda ise bu farklılığın hangi grup veya gruplardan kaynaklandığını belirleyebilmek üzere ise Post-Hoc testlerinden homojenlik sonuçlarına göre LSD ve Dunnet T3 testleri kullanılmıştır. Lisanslı sporcuların akademik erteleme puanlarının spor yapmayan öğrencilere göre daha yüksek olduğu tespit edilmiştir. Akademik ortalaması düşük olan öğrencilerin teknolojik bağımlılıklarının yüksek olduğu belirlenmiştir. Teknoloji bağımlılığı arttıkça okula bağlılık düzeylerinin de azaldığı tespit edilmiştir. Ayrıca korelasyon sonucuna göre teknoloji bağımlılığı arttıkça akademik erteleme düzeylerinin de arttığı tespit edilmiştir.
Case report: Identification of a rare homozygous missense variant in the PKLR gene reported for the first time in transfusion-dependent Saudi Patient
Authors: Zahed Rawabi , Sajer Bayan
Published: July 2023

Red cell pyruvate kinase deficiency is one of the most common erythrocytic glycolytic pathway defects connected with congenital non-spherocytic anemia. The condition inherited as an autosomal recessive Mendelian trait is caused by mutations in the PKLR gene located on chromosome 1q21. Pyruvate kinase enzyme is crucial in the energy-producing glycolysis pathway that provides red blood cells with the primary source of energy (ATP). We report here a case of a Saudi female patient that was initially diagnosed at a few months old with beta-thalassemia major and was treated with regular blood transfusions and iron overload management. At the time of our sample collection, the patient was recently transferred to King Abdul Aziz University Hospital. Genetic testing was performed to identify the disease-contributing variant of beta-thalassemia using TaqMan genotyping of six common beta-thalassemia variants (negative results). NGS targeted HBB gene sequencing which did not reveal any related variants. MLPA was performed to rule out alpha thalassemia diagnosis. The use of whole genome sequencing revealed a rare missense variant in the PKLR gene c.1015G>A (D339N) in a homozygous state that correlates to her severe phenotype. Documenting this incident will aid medical staff in providing appropriate care to similar cases and highlights the importance of following up with the diagnosis investigation process to minimize misdiagnosis incidences.
Dosimetric effects and impacts caused by a carbon fiber table and its accessories in a linear accelerator
Authors: Alabedi Haydar H. , Al Musawi Mustafa S. , Mohammed Ali Nabaa
Published: July 2023

Objective : Most contemporary treatment planning systems (TPS) exclude the couch during treatment planning. The present investigation aimed to evaluate the impact of couches and accessories on radiation therapy planning by quantifying the degree of attenuation for two-photon beam energies, 6 MV and 10 MV, at two different field sizes, 5 cm x 5 cm and 10 cm x 10 cm.  

Methods: An x-ray radiation beam at two energies (6 MV and 10 MV) generated by a linear accelerator (Elekta Synergy). The output dose was measured using a digital parallel plate ionization chamber of the IBA cc13 type (IBA Dosimetry, Germany), and the readings were recorded with a 2944 Farmer Type chamber. Different commercially available couch tops and accessories evaluated in this study.

Results: The results show that the highest attenuation values were observed at 1300 gantry angles for both energies and field sizes. The lowest attenuation values were recorded at 1000 gantry angles with 6 MV energy for 5cm x 5cm and 10cm x 10cm field sizes. The breast board with D level demonstrated the highest attenuation of 6.27% and 5.51% for 6 MV and 10 MV energies, respectively.

Conclusion: the findings indicate that the degree of attenuation is not uniform across all angles and may exceed tolerable limits, indicating the need for careful consideration during treatment planning to ensure optimal treatment outcomes.
Kualitas Cashew Biscotti Dengan Bahan Tepung Kulit Jeruk Manis
Authors: Susastrawan I Gede , Kuntariati Utik
Published: July 2023

Tujuan penelitian ini adalah untuk mengetahui kualitas cashew biscotti dengan bahan tepung kulit jeruk manis (citrus x sinensis). Untuk menciptakan inovasi dan gagasan baru tentunya dari limbah kulit jeruk manis (citrus x sinensis) yang sering di buang dengan percuma oleh masyarakat. Metode penelitian yang digunakan pada penelitian ini adalah metode penelitian kuantitatif dengan jenis penelitian eksperimental dan teknik pengumpulan data yang dilakukan secara observasi dan kuesioner. Dalam menentukan kualitas dari cashew biscotti dengan menggunakan tepung kulit jeruk manis (citrus x sinensis) dinilai dengan menggunakan teknik uji organoleptik yang diujikan kepada 30 panelis untuk menguji kualitas organoleptik dari cashew biscotti. Diantaranya 15 panelis merupakan yang memiliki keahlian dan pengetahuan di bidang food and beverage, dengan aspek yang diuji meliputi aspek taste, color, texture, dan flavor. Hasil dari penelitian yang sudah dilakukan penulis dengan 2 buah cashew biscotti, yaitu cashew biscotti dengan menggunakan 100% tepung terigu (P0) dan cashew biscotti dengan menggunakan 100% tepung kulit jeruk manis (citrus x sinensis) (P1) sebagai pembanding. Berdasarkan hasil penelitian, ditemukan bahwa cashew biscotti dengan menggunakan 100% tepung terigu (P0) memiliki kualitas taste very delicious, color slightly brown, texture crunchy enough, flavor sweet sedangkan cashew biscotti dengan menggunakan 100% tepung kulit jeruk manis (citrus x sinensis) (P1) memiliki Taste Delicious, Color Brown, Texture Crunchy Enough, Flavor Sweet Enough.
 
This study aimed to determine the quality of cashew biscotti with sweet orange peel flour (citrus x Sinensis). To create innovations and new ideas, of course, from waste sweet orange peel (citrus x Sinensis) which is often thrown away in vain by the community. The research method used in this study is quantitative with experimental research and data collection techniques carried out by observation and questionnaires. In determining the quality of cashew biscotti using sweet orange peel flour (citrus x Sinensis) it was assessed using an organoleptic test technique which was tested on 30 panelists to test the organoleptic quality of cashew biscotti. Among them, 15 panelists have expertise and knowledge in the field of food and beverage, with aspects tested covering aspects of taste, color, texture, and flavor. The results of the research that the author has done with 2 cashew biscotti, namely cashew biscotti using 100% wheat flour (P0) and cashew biscotti using 100% sweet orange peel flour (citrus x Sinensis) (P1) as a comparison. Based on the results of the study, it was found that cashew biscotti using 100% wheat flour (P0) had a very delicious taste quality, slightly brown color, crunchy enough texture, and sweet flavor while cashew biscotti using 100% sweet orange peel flour (citrus x Sinensis) ( P1) has Taste Delicious, Color Brown, Texture Crunchy Enough, Flavor Sweet Enough.
Kualitas Keripik Berbahan Dasar Pelepah Pohon Pisang Raja
Authors: Putra I Putu Andika Pratama , Rinayanthi Ni Made
Published: July 2023

Keripik tergolong cemilan ataupun makanan ringan dengan bentuk irisan tipis yang banyak dikenal di antara masyarakat sebab sifat yang dimiliki yakni tidak terlalu mengenyangkan, gurih, renyah dan beraneka rasa misalnya pedas, asin, dan manis. Oleh karena itu, penulis berinisiatif mengembangkan inovasi dalam memanfaatkan pelepah pohon pisang raja sebagai bahan utamanya dalam pembuatan keripik. Karenanya, tujuan yang dibawa penelitian ini yakni guna mengetahui inovasi keripik berbahan dasar pelepah pohon pisang raja yang dilihat berdasar aspek kuesioner, uji organoleptik, serta biaya produksi pembuatan keripik pelepah pohon pisang raja. Untuk penelitian ini memanfaatkan data berjenis kuantitatif dan data kualitatif. Analisis deskriptif kualitatif, analisis biaya dan analisis deskriptif kuantitif yakni teknik analisis yang dipakai peneliti. Hasilnya memperlihatkan bahwasannya keripik batang pisang raja menghasilkan warna yang menarik, rasa yang sangat enak, tekstur yang renyah, serta aroma yang sedap. Dari aspek biaya yang dihabiskan dalam produksi adalah Rp. 10.375/ 15 pcs. Harga 1 pcs keripik batang pisang raja adalah Rp. 691.
 
Chips are snacks or snacks in the form of thin slices that are very popular among the public because they are crunchy, savory, not too filling and are available in various flavors such as salty, spicy, and sweet. Therefore, the author took the initiative to develop innovations in utilizing the midrib of the plantain tree as the main ingredient in making chips. Therefore, this study aims to determine the innovation of chips made from plantain tree midribs in terms of organoleptic test aspects, questionnaires, and production costs of making plantain tree midrib chips. In this study, the types of quantitative data and qualitative data were used. The data analysis technique used is descriptive qualitative analysis, quantitative descriptive analysis, market analysis, and cost analysis. The results of this study indicate that the plantain stem chips produce a very good taste, attractive color, crunchy texture, and delicious aroma. From the aspect of the cost spent in production is Rp. 10.375/ 15 pcs. The price of 1 pcs of plantain stem chips is Rp. 691.
Kualitas Teh Melati Dengan Campuran Bubuk Kulit Manggis Sebagai Inovasi Minuman Terbaru
Authors: Aryandika I Putu Gede Nanda , Muliadiasa I Ketut
Published: July 2023

Penelitian ini bertujuan untuk mengetahui kualitas dan keawetan teh melati dengan campuran ekstrak bubuk kulit manggis, biaya produksi yang digunakan dalam pembuatan teh melati dengan campuran bubuk ekstrak kulit manggis, harga jual yang sesuai dan minat beli konsumen terhadap produk teh melati dengan campuran ekstrak bubuk. kulit manggis. Teknik analisis yang digunakan adalah analisis kuantitatif, yang menggambarkan kualitas organoleptik dan biaya produksi pembuatan teh melati dengan campuran bubuk kulit manggis. Hasil uji organoleptik kualitas menyimpulkan bahwa kualitas teh melati dengan campuran bubuk kulit manggis berasa manis, sangat harum, tekstur cukup cair dan warna kurang cerah. Biaya produksi yang dibutuhkan adalah Rp 3.630,- untuk satu gelas atau 150 ml teh dengan campuran bubuk ekstrak kulit manggis. Pada uji minat beli konsumen, 95% panelis tertarik untuk membeli produk ini.
 
This study aims to determine the quality and durability of jasmine tea with a mixture of mangosteen peel powder extract, production costs used in making jasmine tea with a mixture of mangosteen peel extract powder, suitable selling prices and consumer buying interest in jasmine tea products with a mixture of powdered extracts. mangosteen peel. The analytical technique used is quantitative analysis, which describes the organoleptic quality and production costs of making jasmine tea with a mixture of mangosteen peel powder. The results of the organoleptic test showed that the quality concluded that the quality of jasmine tea with a mixture of mangosteen peel powder was sweet in taste, very fragrant, quite liquid in texture and less bright in color. The production cost required is IDR 3,630, - for one glass or 150 ml of tea with a mixture of mangosteen peel extract powder. In the consumer buying interest test, 95% of the panelists are interested in buying this product.
Key role of histological and PCR studies in the differential diagnosis of heart valve disease in Takayasu’s arteritis, infective endocarditis and myxomatous degeneration
Authors: Pisaryuk Alexandra S. , Kotova Elizaveta O. , Moiseeva Alexandra Yu. , Domonova Elvira A. , Tsimbalist Natalia S. , Meray Imad A. , Safarova Ayten F. , Bogdanova Tatiana G. , Tolokonnikova Natalia E. , Kobalava Zhanna D.
Published: July 2023

Aortic valve lesion is a common cardiopathy, which may have very diverse causes, from degenerative, congenital and infectious diseases to autoimmune conditions. We present a rare case of Takayasu arteritis and severe heart lesion due to the myxomatous degeneration of the aortic and mitral valve cusps associated with the development of infectious endocarditis (IE) complicated by abscess, fistula, valve perforation and recurrent acute decompensated heart failure in a young female patient. A combined use of histopathological and PCR analyses of valve tissues was critically important for differential diagnosis of the valve lesions, as it made it possible to identify the true cause of the structural cardiopathy associated with myxomatous degeneration and a prior IE. The presence of Takayasu arteritis has played an indirect though apparently decisive role by creating conditions for the development of immunosuppression and determining the disease severity and progression rate.
Vitamin D deficiency conditions in children in the antenatal period from the perspective of prognosis and prevention
Authors: Bogdanova Svetlana V. , Ilyenko Lydia I. , Gureev Aleksey N.
Published: July 2023

Relevance. Irrational nutrition of a pregnant woman, unjustified drug load, inactivity, insufficient insolation, constitute a high risk of vitamin D deficiency. Vitamin D deficiency conditions correlate with the frequency of the pathological course of pregnancy and childbirth, dictating the need for timely correction from the standpoint of optimizing care for the child population. The aim of the study - evaluation of the possibility of predicting vitamin D deficiency conditions in children in the antenatal period using a complex of medical and statistical analysis methods. Materials and Methods. A prospective cohort study of 248 mother-child pairs was conducted. Pregnant women: the main group (148) - receiving vitamin D prophylactically at a dose of 1000 MG (Aquadetrim) when registering. The comparison group was those who did not receive vitamin D (100). Inclusion criteria: absence of exacerbation of chronic pathology, allergic reactions, malabsorption syndrome, obesity, diabetes, taking HA, antiepileptic drugs, hyperparathyroidism, severe infections. All women were examined at the end of the 3rd trimester and the postpartum period. Children were observed of 248 children born to pregnant women of two groups. All children were observed with the informed consent of their parents. The duration of observation is up to 3 years. An assessment of the somatic status and general clinical examinations were carried out. Risk factors were assessed using mathematical and statistical methods to compile a prognostic scenario for the development of vitamin D deficient conditions. Results and discussion. Based on the data obtained using the statistical analysis method, it was found that the pathological course of pregnancy and childbirth in women who received vitamin D during pregnancy according to the RR data, AtR were significantly less frequent. Newborns of the main group had higher mass-growth indicators, significantly less often insufficiency, vitamin D deficiency, neurological symptoms; subsequently, a lower incidence of allergic diseases, acute respiratory viral infections, changes in the bone system. Conclusions. Evaluation of the possibility of predicting vitamin D deficiency conditions in children in the antenatal period using a complex of medical and statistical analysis methods reduces the risk of: pathological course of pregnancy, childbirth, the frequency of vitamin D deficiency and deficiency in newborns, affecting mass-growth indicators at birth, neurological symptoms, allergic diseases, respiratory infections in infancy, changes in the bone system in young children. Prevention of the development of vitamin D deficiency conditions in the antenatal period makes it possible to optimize the care of the child population.
Urgent total pancreatoduodenectomy for profuse gastro-intestinal bleeding caused by renal cancer metastases to the pancreas
Authors: Mylnikov Andrey G. , Klimov Aleksey E. , Kurbanniyozov Temurbek Sh. , Bujmestru Nina V. , Chernjaeva Anna A. , Gusarova Tatyana A.
Published: July 2023

Renal cancer (RC) can spread to different organs, metastatic damage of the pancreas is quite rare. But, in contrast of primary and other metastatic malignant tumors, pancreatic RC metastases can be resectable in 80 % of cases with nearly 90 % 5-year survival rate. Pancreatic oncologic surgery includes 3 different types of resection: distal pancreatic resection, pancreatoduodenal resection and total duodenopancreatectomy. The last type is the most extensive procedure, incorporates except of total removal of the pancreatic gland, total excision of duodenum and, in some cases, partial gastrectomy. In surgery of pancreatic tumors using of total duodenopancreatectomy is relatively rare (6,7-12,3 %). And in spite of low mortality (5-6,25 %) in recent years, whole removal of the gland inevitably leads to severe metabolic changes such as complete exocrine insufficiency and unstable insulin-depended diabetes mellitus which need lifetime medical correction. Gastrointestinal bleeding from pancreatic metastases of RC as a disease complication occurs quite rare and appears due to invasion of cancer tissue located in the pancreatic head to duodenal mucosa and then ulcerated. There are few single observations or little series (2-4 cases) described in literature. Pancreatoduodenal resection in such cases is the main type of surgical intervention. Now we present a case of successful urgent total duodenopancreatectomy, performed for recurrent profuse gastrointestinal bleeding from pancreatic head metastasis of RC invaded duodenum after previously radical nephrectomy. During the operation several cancer nodes in the pancreatic body and tail were found that defined the total gland removal. Postoperative period proceeded uneventfully and the patient was discharged on 15th day. Uniqueness of this case is that emergency total duodenopancreatectomy was successfully done for profuse gastrointestinal bleeding as the only possible chance for cure. We have not found similar reports in the available literature.
DONATION FOR CHURCH CONSTRUCTION VIEWED FROM SAYYID THANTHAWI'S PERSPECTIVES
Authors: Bahar Muchlis
Published: July 2023

This research aimed at investigating Sayyid Thanthawi's ijtihad pattern and methodology for deciding the law on making donations for church construction. As stated by Islamic teachings, Christians do not regard God to be One since they believe in the Trinity (the Father, the Son, and the Holy Spirit). Within the national state, however, Muslims and Christians coexist, work together, and assist one another. Conflicts of interest in coexistence might emerge as a result of religious differences. This current study is library research using qualitative descriptive analysis. The data used were secondary data in the form of books written by Sheikh Sayyid Thanthawi, Mufti of the Arab Republic of Egypt, as well as other relevant books. This research found that from Sayyid Thanthawi's viewpoint, a Muslim is permitted to donate to the construction of a church. Sayyid Thanthawi's Ijtihad is moderate since it considers the greater benefit and fosters harmony among religious communities, without ignoring the demands of the Qur'anic text. The ijtihad approach employed is the maslahah theory, which takes into account the benefits and harm that would be caused by the Fatwa's issuing. The implication of this ijtihad is the establishment of concord and peace between Muslims and Christians in Egypt. However, some Egyptian religious scholars restrict donations to church construction, arguing that it is the same as donating to the development of gambling businesses and nightclubs.
Pengembangan Strategi Pemasaran Potensi Gampong Lamme Melalui Media Digital
Authors: Kurniawan Indra , Rasyidah  , Rohimi Aman , Silva Roziannur Hidayatullah , Fathiyah Husna , Jannah Nasution Miftahul , Hasanah Nurul
Published: July 2023

Media digital adalah jalan yang tepat membuka peluang dalam pengembangan produk. Gampong Lamme tepatnya di kecamatan Jaya merupakan salah satu daerah yang mempunyai produk-produk unggul diantara kerajinan Tudong, Jeruk Bali, Kurma Daya, Lamme Candy, dan Chingkuy. Memang produk-produk ini luar biasa apabila di promosikan keluar daerah, namun fasilitas Media digital kurang memadai. Padahal Media digital sudah mudah diaplikasikan untuk para penggunannya. Oleh karena itu, maksud dari penelitian ini adalah pengembangan media digital bagi masyarakat Gampong Lamme melalui website market place. Penelitian ini adalah penelitian berbasis pengabdian masyarakat dilaksanakan sebagai rangkaian program kerja.  Teknik hasil assesment partisipatif terhadap potensi gampong, lalu di bangun rencana kerja sama untuk merealisasikan bersama. Berdasarkan hasil penelitian yang dilakukan, dapat disimpulkan pentingnya daerah memiliki media digital yang sudah ada, sehingga apabila sudah terealisasikan bahan, produk-produk yang bisa menambah ekonomi masyarakat, maka melalui strategi pemasaran melalui website market place semua akan menjadi mudah.
Pengembangan Wisata Masjid Baitussalam Nyak Sandang Sebagai Icon Wisata Religi di Aceh Jaya
Authors: Arifah Husnul , Santoso Hari , Muttaqin Iqbal , Karnia Sari Intan , Zahara Fatimah , Liyana Budi Pratama Egi , Fitria Moza , Maulana Ahmad , Kholil Asyrof , Azan Muhammad , Rina Ridara Apria , Anjarwati Mega , Yubentro Andre
Published: July 2023

This research is used as a form of student service for the Malay Column III Real Work Lecture to the people of Aceh Jaya (Lamno) Gampong Lhuet. Religious tourism is the application of the concept of halal tourism which has the aim of meeting human spiritual needs in strengthening faith by visiting places that have religious values. gampong lhuet has great potential and opportunities in developing religious tourism, namely the Baitussalam Nyak Sandang Mosque as its icon. Nyak clothes, who is he? Maybe many do not know who he is. And thanks to his request, the President of the Republic of Indonesia, Joko Widodo, built the Baitussalam mosque for him. The method used in this study is a descriptive qualitative method to describe the potential for religious tourism in the region, with primary data sources and secondary data sources. There are several things that must be considered in the development of this religious tourism, namely the potential, opportunities, and challenges in development. And also have to know what strategy to use. The strategy used in this study is to make this religious tourism icon viral on all social media so that it can be famous and known to many people. The strategy has succeeded in attracting visitors coming from various regions.