bluuebunny/crossref_metadata_2025 huggingface dataset:
Carriage of vancomycin-resistant Enterococcus faecium in infants following an outbreak in the neonatal intensive care unit: time to clearance of carriage and use of molecular methods to detect colonization
Authors: Schechner Vered , Lellouche Jonathan , Stepansky Sarit , Mandel Dror , Grisaru-Soen Galia , Wullfhart Liat , Schwartz David , Carmeli Yehuda
Published: January 2022

Among 46 infants colonized with vancomycin-resistant Enterococcus faecium during an outbreak in a neonatal intensive care unit, the estimated time until half had achieved clearance was 217 days. All 40 infants who completed follow-up cleared carriage by 1 year. No predictors of prolonged carriage (> 6 months) were identified.
Partisanship, Fiscal Transfers, and Social Spending in Korea: The Politics of Partial Decentralization
Authors: Ha Eunyoung , Lee Dong Wook
Published: January 2022

In the last three decades, many Asian democracies have decentralized their political systems to promote the democratic, equal, and efficient distribution of national resources across regions. Nonetheless, most of these countries, including South Korea, are still in a stage of “partial fiscal decentralization,” in which locally elected officials have spending authority, while a significant portion of their financing relies on transfers from the central government. This article argues that the decentralized distribution is significantly influenced by the partisan interests of central and local governments. The central government transfers more funds to local governments that their co-partisans govern, and local incumbents follow partisan policy priorities to obtain the allocation of available fiscal resources. This argument is strongly supported by the empirical analysis of subsidy transfers and regional social expenditures in South Korea from 2002 to 2015. First, we find that the central government in Korea transfers larger subsidies to politically aligned regions. Second, regional governments with larger subsidy transfers have higher levels of social expenditures. Third, governors or mayors affiliated with a progressive party spend significantly more on social welfare and education than do those affiliated with a conservative party.
Nonspherical dynamics and microstreaming of a wall-attached microbubble
Authors: Fauconnier M. , Mauger C. , Béra J.-C. , Inserra C.
Published: January 2022

Acoustic microstreaming is a nonlinear response of a fluid that undergoes high-amplitude acoustic stimulation and tends to viscously absorb it. The present experimental study investigates the generation of acoustic microstreaming induced by an oscillating wall-attached bubble undergoing nonspherical shape modes. From a microscope top view, the formation of particular flow signatures is explored for the main classes of spherical harmonics

$Y_{nm}(\theta, \phi )$

: zonal (

$m = 0 < n$

), sectoral (

$n = m > 0$

) and tesseral (

$0 < m < n$

) oscillation. The microstreaming induced by a bubble animated by a sectoral mode alone reveals a pattern characterized by a

$4n$

-lobe flower shape. Tesseral modes give rise to 4m-lobe flower-shaped patterns. Finally, when sectoral and zonal modes coexist, two kinds of pattern stand out:

$2n$

-lobe flower shape and

$n$

-pointed star shape. The preferential emergence of one or another streaming pattern is discussed on the basis of the amplitude and phase shift between both shape modes.
Managing physical and virtual work environments during the COVID-19 pandemic: improving employee well-being and achieving mutual gains
Authors: Pinnington Ashly H. , Ayoko Oluremi B.
Published: January 2022

Contemporary organisations continue to use flexible workspace configurations and increasingly are adopting more automated and intelligent digital systems to organise work. Workspace configurations have various forms and arrangements composed of the physical workspace (such as open-plan office spaces) and virtual workspace (e.g., teleworking). The aim of this Special Issue (SI) is to stimulate inquiry into the role of management, organisation and HRM in promoting mutual gains for employers and employees working in these environments. The essence of mutual gains is that HRM practices lead to greater employee well-being and increased employee performance, the latter being especially important to employers for achieving organisational goals. In ‘managing physical and virtual work environments during the Covid-19 pandemic’, we consider how work is organised in challenging physical and virtual workspace configurations as well as how people engage in activities that are paced and informed by automated and digital technologies. Our aim is to encourage exciting research on the role and implementation of management, organisation and HRM in physical and virtual workspace configurations, stimulate new scholarly discussions on the topic, and increase understanding of the application of new technology systems and tools. A specific objective of this SI is therefore to increase academic knowledge on the opportunities and challenges faced by employees working in different physical and virtual workspace conditions, and consider the consequences for employee well-being (Guest, 2017; Van De Voorde, Paauwe, & Van Veldhoven, 2012).
The non-thermal emission from the colliding-wind binary Apep
Authors: del Palacio S. , Benaglia P. , De Becker M. , Bosch-Ramon V. , Romero G. E.
Published: January 2022

Therecently discovered massive binary system Apep is the most powerful synchrotron emitter among the known Galactic colliding-wind binaries. This makes this particular system of great interest to investigate stellar winds and the non-thermal processes associated with their shocks. This source was detected at various radio bands, and in addition the wind-collision region was resolved by means of very-long baseline interferometric observations. We use a non-thermal emission model for colliding-wind binaries to derive physical properties of this system. The observed morphology in the resolved maps allows us to estimate the system projection angle on the sky to be

$\psi \approx 85^\circ$

. The observed radio flux densities also allow us to characterise both the intrinsic synchrotron spectrum of the source and its modifications due to free–free absorption in the stellar winds at low frequencies; from this, we derive mass–loss rates of the stars of

$\dot{M}_\mathrm{WN} \approx 4\times10^{-5}\;\mathrm{M}_\odot\,\mathrm{yr}^{-1}$

and

$\dot{M}_\mathrm{WC} \approx 2.9\times10^{-5}\;\mathrm{M}_\odot\,\mathrm{yr}^{-1}$

. Finally, the broadband spectral energy distribution is calculated for different combinations of the remaining free parameters, namely the intensity of the magnetic field and the injected power in non-thermal particles. We show that the degeneracy of these two parameters can be solved with observations in the high-energy domain, most likely in the hard X-rays but also possibly in

$\gamma$

-rays under favourable conditions.
Explaining Machine Learning Decisions
Authors: Zerilli John
Published: January 2022

The operations of deep networks are widely acknowledged to be inscrutable. The growing field of Explainable AI (XAI) has emerged in direct response to this problem. However, owing to the nature of the opacity in question, XAI has been forced to prioritise interpretability at the expense of completeness, and even realism, so that its explanations are frequently interpretable without being underpinned by more comprehensive explanations faithful to the way a network computes its predictions. While this has been taken to be a shortcoming of the field of XAI, I argue that it is broadly the right approach to the problem.
Two Notions of Ecological Function
Authors: Dussault Antoine C.
Published: January 2022

This paper discusses Millstein’s (2020) criticism of the consensus view formed against selected-effects ecological functions. I argue that Millstein’s defense of coevolution-based selected-effects ecological functions applies to a notion of function as anactivity, whereas proponents of the consensus view are concerned with a notion of ecological function as the contribution of an organism, population, species, or abiotic item to the maintenance of its community and/or the functioning of its ecosystem. Millstein’s arguments hence do not invalidate the consensus view but draw attention to a notion of function that has been neglected in philosophical discussions and that deserves more attention.
U–Pb geochronology of Upper Triassic – Lower Jurassic detrital sequences from SE margin of the South China Block: implications for Palaeo-Pacific subduction and tectonic evolution
Authors: Kong Jin-Tao , Xu Zhong-Jie , Tao Guo-Zhi , Cheng Ri-Hui , Wang Liao-Liang
Published: January 2022

We performed U–Pb dating of detrital zircons and conducted petrological and whole-rock geochemical analyses to assess the provenance of the Upper Triassic – Lower Jurassic clastic rocks in the southeastern margin of the South China Block. Detrital zircon U–Pb ages are mainly classified into age groups of 2000–1700, 900–700, 490–390 and 280–210 Ma, consistent with derivation from the Jiangnan orogenic belt, Nanling Belt, as well as Wuyi and Yunkai domains. Lower Jurassic samples yield a special main age population of 200–190 Ma, and these detrital zircon grains have low Th/U and Nb/Hf ratios and high Th/Nb and Hf/Th ratios, showing they are derived from a continental magmatic arc. However, the cross-correlation and likeness coefficients of kernel density estimates of Upper Triassic and Lower Jurassic sandstones are 0.8608 and 0.8403, indicating that their populations are highly similar. Since the tectonic setting is the key factor in controlling the relationship between source and sink, the stable supply of identical provenance suggests that the tectonic setting did not significantly change during Late Triassic – Early Jurassic time. Sandstone petrography, regional facies distribution and the detrital zircon age patterns all reflect a consistent tectonic setting for the South China Block during Late Triassic – Early Jurassic time. The Palaeo-Pacific subduction therefore did not control the tectonic evolution of the South China Block until after the Early Jurassic Epoch.
The People and the Making of India's Constitution
Authors: Shani Ornit
Published: January 2022

This article explores the engagements of people and various civic organizations, even from the margins of society, with the making of India's constitution during the early stages of its drafting. Using hitherto unstudied archival materials, it examines constitutional visions, demands, conceptions of inclusion, and constitutional proposals, as these were expressed at the time by people outside of the Constituent Assembly. The conventional understanding has been that the constitution was a product of elite consensual decision-making, and that India's nationalist leaders endowed it from above. This article shifts the historical inquiry away from the Constituent Assembly onto the ways the constitution-making process was experienced, related to, and understood from below by ‘We the People’ – those on behalf of whom the constitution would ultimately be enacted. Hence, it constructs a new perspective on the making of India's constitution. In doing so, the article throws light on the significance of people's interactions with the constitution-making process on the nature of India's decolonization, on its successful democratic transition, and on the rooting and endurance of its constitution against many odds.
Using Patent Capital to Estimate Tobin’s Q
Authors: Woeppel Michael
Published: January 2022

I construct a new proxy for Tobin’s Q that incorporates the replacement cost of patent capital. This proxy, which I call patent Q, explains up to 62% more variation in investment than other proxies for Q. Furthermore, investment is more sensitive to patent Q than to other proxies for Q. Although investment is predicted more accurately by, and is more sensitive to, patent Q, controlling for patent Q leads to relatively larger, not smaller, cash flow coefficients. All results are stronger in subsamples with more patent capital. Overall, patent Q strengthens the historically weak investment–Q relation.
Conference on ‘Obesity and the brain’
Authors: Hall Wendy L.
Published: January 2022

The Winter Conference 2021 focused on the theme of obesity and the brain, with symposia on the consequences of obesity on brain function, developments in behavioural change interventions, neurobiology of appetite regulation and obesity treatment, and personalised medicine for obesity prevention and treatment. The first plenary lecture discussed sweetness perceptions and how non-nutritive sweeteners may lead to a mismatch between metabolic signals and reward systems in the brain, and the second plenary lecture presented novel approaches to the treatment of binge-eating disorders. This short report summarises the content of these scientific sessions.
Home ranges of released West Indian manatees Trichechus manatus in Brazil
Authors: dos Santos Sebastião Silva , Medeiros Iara dos Santos , Rebelo Vanessa Araujo , Carvalho Allan Oliveira Barreto , Dubut Jean Paul , Mantovani José Eduardo , Círiaco Raphael Dantas , dos Santos Ryan Emerson Gomes , Marmontel Miriam , Normande Iran Campello , Velôso Thalma Maria Grisi , Borges João Carlos Gomes
Published: January 2022

The distribution of the Vulnerable West Indian manatee Trichechus manatus is influenced by physical and environmental factors such as water salinity, temperature and depth, freshwater supply and the availability of food resources. In Brazil, information on the habitat use of this species is insufficient for effective conservation. Here, we monitored manatees that had been found stranded as calves, rehabilitated in captivity and subsequently released, to identify their home ranges and examine their adaptation to life in the wild. The study, which involved monitoring six manatees using satellite and VHF telemetry systems, was conducted during 2016–2019 in the states of Paraíba, Sergipe and Bahia in north-eastern Brazil. Home range size of individuals was 2.56–42.07 km2 and all fidelity sites (areas used most frequently) were within protected areas. The longest distance travelled from the coastline upriver was 14.24 km and the longest distance offshore was 0.93 km. There were no significant differences in home range data between the dry and rainy seasons, but there was significant difference between the sexes, with males travelling across larger areas than females. All but one of the six individuals met the majority of indicators established in the Brazilian Manatee Reintroduction Protocol, and thus were considered to have successfully adapted to the wild. Our study provides information on patterns of habitat use and areas intensely used by manatees, which can assist protected area managers in defining priority areas for manatee conservation in Brazil.
Prior differences in previous trauma exposure primarily drive the observed racial/ethnic differences in posttrauma depression and anxiety following a recent trauma
Authors: Harnett N. G. , Dumornay N. M. , Delity M. , Sanchez L. D. , Mohiuddin K. , Musey P. I. , Seamon M. J. , McLean S. A. , Kessler R. C. , Koenen K. C. , Beaudoin F. L. , Lebois L. A. M. , van Rooij S. J. H. , Sampson N. A. , Michopoulos V. , Maples-Keller J. L. , Haran J. P. , Storrow A. B. , Lewandowski C. , Hendry P. L. , Sheikh S. , Jones C. W. , Punches B. E. , Kurz M. C. , Swor R. A. , McGrath M. E. , Hudak L. A. , Pascual J. L. , House S. L. , An X. , Stevens J. S. , Neylan T. C. , Jovanovic T. , Linnstaedt S. D. , Germine L. T. , Datner E. M. , Chang A. M. , Pearson C. , Peak D. A. , Merchant R. C. , Domeier R. M. , Rathlev N. K. , O'Neil B. J. , Sergot P. , Bruce S. E. , Miller M. W. , Pietrzak R. H. , Joormann J. , Barch D. M. , Pizzagalli D. A. , Sheridan J. F. , Smoller J. W. , Luna B. , Harte S. E. , Elliott J. M. , Ressler K. J.
Published: January 2022

Background

Racial and ethnic groups in the USA differ in the prevalence of posttraumatic stress disorder (PTSD). Recent research however has not observed consistent racial/ethnic differences in posttraumatic stress in the early aftermath of trauma, suggesting that such differences in chronic PTSD rates may be related to differences in recovery over time.

Methods

As part of the multisite, longitudinal AURORA study, we investigated racial/ethnic differences in PTSD and related outcomes within 3 months after trauma. Participants (n = 930) were recruited from emergency departments across the USA and provided periodic (2 weeks, 8 weeks, and 3 months after trauma) self-report assessments of PTSD, depression, dissociation, anxiety, and resilience. Linear models were completed to investigate racial/ethnic differences in posttraumatic dysfunction with subsequent follow-up models assessing potential effects of prior life stressors.

Results

Racial/ethnic groups did not differ in symptoms over time; however, Black participants showed reduced posttraumatic depression and anxiety symptoms overall compared to Hispanic participants and White participants. Racial/ethnic differences were not attenuated after accounting for differences in sociodemographic factors. However, racial/ethnic differences in depression and anxiety were no longer significant after accounting for greater prior trauma exposure and childhood emotional abuse in White participants.

Conclusions

The present findings suggest prior differences in previous trauma exposure partially mediate the observed racial/ethnic differences in posttraumatic depression and anxiety symptoms following a recent trauma. Our findings further demonstrate that racial/ethnic groups show similar rates of symptom recovery over time. Future work utilizing longer time-scale data is needed to elucidate potential racial/ethnic differences in long-term symptom trajectories.
Constraint characteristics and type synthesis of two families of 1T2R parallel mechanism
Authors: Ju Yongjian , Xu Weisheng , Meng Gang , Cao Yi
Published: January 2022

PU- and P*U*-equivalent parallel mechanisms (PMs) are critical families of PMs with one translational and two rotational (1T2R) degree of freedoms and have always been a research hotspot among lower mobility PMs. However, researches on these two families of PMs remain to be inadequate, and existing types are few and uncomprehensive. In this study, first, general wrench systems of PU-equivalent are derived based on virtual-chain approach and screw theory, revealing its constraint characteristics under general configuration. Cause of one parasitic motion is put forward and general wrench systems of P*U*-equivalent PMs with one parasitic motion are obtained. In addition, constraint analysis has been carried out to figure out constraint characteristics of P*U*-equivalent PMs with three parasitic motions. Second, branch chains are divided by generating constraints, and their structures are synthesized based on the presented rules. Then, the process for type synthesis of PU-equivalent PMs and P*U*-equivalent PMs and a series of novel 1T2R PMs are attained based on this. Finally, a novel PU-equivalent PM, 2PRU-PRUPc, and a novel P*U*-equivalent PM with one parasitic motion, 2PRU-PUU PM, are analyzed, demonstrating the effectiveness of the proposed type synthesis method.
Addressing uncertainty in relative effectiveness assessments by HTA organizations
Authors: Vreman Rick A. , Strigkos George , Leufkens Hubert G. M. , Schünemann Holger J. , Mantel-Teeuwisse Aukje K. , Goettsch Wim G.
Published: January 2022

This study outlines the ways in which different health technology assessment (HTA) organizations deal with uncertainty in relative effectiveness assessments (REAs), using the GRADE framework as a common reference. Guidelines regarding REA and uncertainty assessment methods and three most recent HTA reports (as of April 2020) of seven HTA organizations in Germany, England and Wales, France, the Netherlands, Europe (EUnetHTA), the USA, and Canada were included. First, it was analyzed how each organization addressed uncertainty on the following levels of evidence: (i) individual studies, (ii) body of evidence for one outcome, (iii) body of evidence across all outcomes, and (iv) added net benefit. Second, the extent to which HTA organizations considered the eight domains of certainty of evidence defined by GRADE was assessed. For individual studies, checklists were the most common approach to express uncertainty (4/7 organizations). Uncertainty in the body of evidence for all outcomes and in added benefit was combined in a single conclusion by five organizations. All organizations reported on at least 4/5 downgrading domains of GRADE, while the three upgrading domains were reported less. The operationalization of the assessment of multiple domains was unclear due to vague or absent guidelines. HTA organizations consider most domains of the GRADE framework, but approaches to assess uncertainty within REAs on different levels of evidence differ substantially between organizations. More alignment and guidance on the best methods to deal with uncertainty within HTA could lead to more clarity for stakeholders and to more aligned reimbursement recommendations.
Maternal depressive symptoms and child behavior problems: Attachment security as a protective factor
Authors: Whittenburg Paige N. , Stern Jessica A. , Brett Bonnie E. , Straske M. Davis , Cassidy Jude
Published: January 2022

Maternal depressive symptoms (MDS) have been linked to both child internalizing and externalizing behavior problems. Theory suggests that child attachment security may be a protective factor against the negative effects of MDS. This study examined child attachment security as a buffer of the link between MDS and child internalizing and externalizing behavior problems at two time points in a predominantly African American sample. Participants included mothers (N = 164; Mage = 29.68 years; 76% African American) and their preschool-aged children (60% girls; Mage = 44.67 months) recruited from four Head Start centers in low-income neighborhoods in Baltimore, Maryland. MDS were concurrently associated with child internalizing and externalizing behavior problems at both time points. No significant main effects of child attachment security on behavior problems emerged; however, child attachment moderated the association between MDS and child internalizing behavior problems at Time 2, such that MDS predicted greater child internalizing problems when attachment security was low, and the effect was attenuated when attachment security was high. No interaction emerged for child externalizing problems. Findings suggest that secure attachment in early childhood can serve as a protective factor in the context of parental risk. We discuss implications for intervention and the intergenerational transmission of psychopathology.
Syringaldehyde is a novel smoke-derived germination cue for the native fire-chasing tobacco, Nicotiana attenuata
Authors: Cao Dechang , Schöttner Matthias , Halitschke Rayko , Li Dapeng , Baldwin Gundega , Rocha Catarina , Baldwin Ian T.
Published: January 2022

Smoke-derived seed germination is an important trait for plants to colonize postfire habitats. The well-characterized smoke-derived chemicals of karrikins germinate seeds of species not known to occur after fires in nature. Hence, the ecologically relevant germination cues in smoke remain to be explored for native postfire plants. With the fire-chaser, Nicotiana attenuata, we revisit a bioassay-driven fractionation of liquid smoke to identify ecologically relevant germination cues. By combining bioassay-guided fractionation and comparative unbiased metabolomics, we developed a robust and efficient method to identify germination cues in smoke. Syringaldehyde (SAL) was re-identified as a germination cue in fractions of liquid smoke that promote seed germination. SAL was found to be produced during wildfires in the plant's native habitat, efficiently adsorbed to N. attenuata seeds from aqueous solutions and not readily leached from soil and accurately predicted the boundaries of natural fire events that reflect the occurrence of native postfire N. attenuata populations. We propose that SAL is an ecologically relevant germination cue in smoke for this species.
First report of a percutaneous valve-in-Valve implantation of tricuspid valve in a systemic right ventricle
Authors: Mumtaz Zeeshan Ahmed , Pavithran Sreeja , Sivakumar Kothandam
Published: January 2022

Severe tricuspid regurgitation in corrected transposition of great arteries is treated with early bioprosthetic replacement to prevent right ventricular failure. When bioprosthesis degenerates, surgery on cardioplegic arrest further complicates right ventricular function. We report the first transcatheter valve-in-valve implantation of tricuspid valve in a systemic right ventricle in corrected transposition describing the modifications due to anatomical differences in these patients.
Novel Negative Pressure Helmet Reduces Aerosolized Particles in a Simulated Prehospital Setting
Authors: Hunt Nathaniel , Masiewicz Spencer , Herbert Logan , Bassin Benjamin , Brent Christine , Haas Nathan L. , Tiba Mohamad Hakam , Lillemoen Jon , Lowell Mark J. , Lott Isabel , Basinger Matthew , Smith Graham , Ward Kevin R.
Published: January 2022

Background/Objective:

The coronavirus disease 2019 (COVID-19) pandemic has created challenges in maintaining the safety of prehospital providers caring for patients. Reports have shown increased rates of Emergency Medical Services (EMS) provider infection with COVID-19 after patient care exposure, especially while utilizing aerosol-generating procedures (AGPs). Given the increased risk and rising call volumes for AGP-necessitating complaints, development of novel devices for the protection of EMS clinicians is of great importance.

Drawn from the concept of the powered air purifying respirator (PAPR), the AerosolVE helmet creates a personal negative pressure space to contain aerosolized infectious particles produced by patients, making the cabin of an EMS vehicle safer for providers. The helmet was developed initially for use in hospitals and could be of significant use in the prehospital setting. The objective of this study was to determine the efficacy and safety of the helmet in mitigating simulated infectious particle spread in varied EMS transport platforms during AGP utilization.

Methods:

Fifteen healthy volunteers were enrolled and distributed amongst three EMS vehicles: a ground ambulance, a medical helicopter, and a medical jet. Sodium chloride particles were used to simulate infectious particles, and particle counts were obtained in numerous locations close to the helmet and around the patient compartment. Counts near the helmet were compared to ambient air with and without use of AGPs (non-rebreather mask [NRB], continuous positive airway pressure mask [CPAP], and high-flow nasal cannula [HFNC]).

Results:

Without the helmet fan on, the particle generator alone and with all AGPs produced particle counts inside the helmet significantly higher than ambient particle counts. With the fan on, there was no significant difference in particle counts around the helmet compared to baseline ambient particle counts. Particle counts at the filter exit averaged less than one despite markedly higher particle counts inside the helmet.

Conclusion:

Given the risk to EMS providers by communicable respiratory diseases, development of devices to improve safety while still enabling use of respiratory therapies is of paramount importance. The AerosolVE helmet demonstrated efficacy in creating a negative pressure environment and provided significant filtration of simulated respiratory droplets, thus making the confined space of transport vehicles potentially safer for EMS personnel.
Online breast-feeding support groups as a community asset in Lebanon after Beirut explosion
Authors: Ramadan Nabiha , Bonmatí-Tomas Anna , Juvinyà-Canal Dolors , Ghaddar Ali
Published: January 2022

Objective:

Breast-feeding rates are unsatisfactory in Lebanon. Social media groups could play an important role in promoting breast-feeding in normal conditions and post crisis. The aim of this study is to identify breast-feeding challenges, facilitators and assets and to describe how community assets via social media could build community resilience to pandemic’s and disaster’s effects.

Design:

A two-phase qualitative content analysis was performed on posts and comments collected from a Facebook breast-feeding support group. Data were categorised into themes, categories and subcategories.

Setting:

Posts and comments retrieved from a Facebook breast-feeding support group in Lebanon during the month of August 2020.

Participants:

Group members: mothers who breastfed, breast-feeding mothers and group admins that are lactation consultants.

Results:

In phase one, breast-feeding ‘Challenges’ identified were lack of support from peers and family, lack of supportive policies, lack of knowledge and maternal stress related to political instability, COVID-19 and economic crisis. ‘Assets and facilitators’ included community support and donations. In phase two, analysis revealed how assets were being used on social media platform to build community resilience post crisis, through access to social support in challenging times, community engagement, material resources and transformative potential.

Conclusion:

Challenges faced during breast-feeding were diminished due to the support and assets received on a Facebook breast-feeding support group, and social media has been shown to be an important community asset implicated in empowering women to breastfeed and to build community resilience in moments of crisis.
Precise and Dynamic Temperature Control in High-Resolution Microscopy with VAHEAT
Authors: Icha Jaroslav , Böning Daniel , Türschmann Pierre
Published: January 2022

Temperature is a key parameter in most biological and physical systems. It is, however, an inherent technological challenge to precisely track and control the temperature of small sample volumes when using high- and super-resolution microscopes. Various effects can cause a deviation of the sample temperature from its expected value, specifically in the observed volume or field-of-view. These effects include direct thermal contact of the objective lens and the coverslip via immersion medium, illumination-induced heating, evaporative cooling, or triggered phase transitions. In this paper, we shed light on these phenomena and introduce our newly developed device VAHEAT, which follows a microscopic approach for controlling and measuring the sample temperature. Our system overcomes traditional limitations of temperature sensing and controlling in high-sensitivity microscopy applications, leading to more reproducible experimental results and conquering new experimental parameter ranges.
Internal Electric Field Profiling of 2D P-N Junctions of Semiconductor Devices by 4D STEM and Dual Lens Electron Holography
Authors: Wang Yun-Yu , Yuan Renliang , Wang Shixin , Wang Zhouguang , Jin Qiang
Published: January 2022

The internal electric field of a 2D P-N junction of a semiconductor is mapped out by two techniques: measuring the deflection of the transmitted beam in micro-STEM mode with acquisition and data fitting of an un-scattered beam image, and through the derivative of electrostatic potential maps by dual lens electron holography. Comparable results of the P-N junction internal electric field measured with these two techniques are reported.
Groups as Lawmakers: Group Bills in a US State Legislature
Authors: Kroeger Mary
Published: January 2022

Scholars posit that groups play an important role in the legislative process and legislator decision making, but find these questions difficult to empirically study due to the private information exchanges. This article exploits a legislative reporting institution to explore group involvement in policy making. In the California state legislature, extra-legislative individuals or organizations that write legislation and secure a legislator to author the bill may be listed as sponsors. Data come from California bill analyses and extend from 1993 to 2014. This group tactic is frequently used: 40% of bills introduced and over 60% of bills that become law list an extra-legislative sponsor. Group sponsorship is significantly related to passage, even after matching on a number of covariates. Legislators use fewer group bills and substitute out of group bills as they gain experience. Group input serves as an integral part of a legislative portfolio and the agenda-setting stage of legislative decision making.
Field bindweed control with quinclorac in highbush blueberry
Authors: Moretti Marcelo L. , Peachey R. Edward
Published: January 2022

Field bindweed is a perennial vining weed with vigorous growth, and is commonly found in highbush blueberry fields of Oregon. It requires and integrated strategy using multiple applications of postemergence herbicides and hand weeding for adequate control. Quinclorac is a herbicide that has been shown to control field bindweed, but no information is available indicating the tolerance of blueberry to quinclorac. The objective of this study was to evaluate the response of blueberry to quinclorac and to evaluate field bindweed control with quinclorac in different mixtures. Three groups of field studies were designed to assess 1) single application control of field bindweed, 2) use of sequential treatments to control field bindweed, and 3) long-term impact of quinclorac on field bindweed. In the single application control studies, a single application of quinclorac at 210 or 420 g ai ha−1 alone or in a mixture with rimsulfuron (35 g ai ha−1) or carfentrazone (35 g ai ha−1), controlled field bindweed by 69% to 76% while reducing its biomass between 22% and 44% compared to the nontreated control (61 g m−2). In a sequential treatment study, a single application of quinclorac (420 g ai ha−1) provided 83% to 100% control of field bindweed, outperforming three sequential applications of carfentrazone. In the long-term study, a single application of quinclorac reduced field bindweed biomass by 50% to 82% in 2019 and 62% to 87% in 2020. These results indicate that quinclorac can be safely applied to highbush blueberry plants. Early spring applications of quinclorac to field bindweed will reduce or eliminate the need for subsequent applications later in the season.
Drought Diagnosis: What the Medical Sciences Can Teach Us
Authors: Walker David W. , Cavalcante Louise , Kchouk Sarra , Ribeiro Neto Germano G. , Dewulf Art , Gondim Rubens S. , Martins Eduardo S. Passos Rodrigues , Melsen Lieke A. , de Souza Filho Francisco de Assis , Vergopolan Noemi , Van Oel Pieter R.
Published: January 2022

Drought management is currently informed by a variety of approaches, mostly responding to drought crisis when it happens. Toward more effective and integrated drought management, we introduce a conceptual drought diagnosis framework inspired by diagnostic concepts from the field of medicine. This framework comprises five steps: 1. Initial diagnostic assessment; 2. Diagnostic testing; 3. Consultation; 4. Communication of the diagnosis; and 5. Treatment and prognosis. To illustrate the need for the proposed approach, four case studies of recently drought‐affected regions were selected: the city of Cape Town, the state of California, the Northeast region of Brazil, and the Horn of Africa. Contrasting elements for these cases include the geographic extent and political boundaries, climate, socio‐economics, and the relevance of different water resources (e.g., rainfall, reservoirs, and aquifers). For each case, we identified documented practices and policies and reflected on them in terms of drought misdiagnosis or incomplete diagnosis that have aggravated socio‐economic and environmental drought impacts. A common example is the preference for technical solutions (e.g., installing infrastructure to augment water supply), rather than measures that reduce vulnerability. Analysis of these four drought case studies confirmed the anticipated need for a comprehensive approach to drought diagnosis for more successful treatment and prevention of drought. Using an analogy with medical science can be helpful toward comprehensively diagnosing droughts for a variety of contexts and assessing the effectiveness of proposed interventions. This framework can help drought managers to be more proactive in enabling drought‐affected regions to become more drought resilient in the future.
Increased Interception Induced by Vegetation Restoration Counters Ecosystem Carbon and Water Exchange Efficiency in China
Authors: Shao Rui , Shao Weiwei , Gu Chunjie , Zhang Baoqing
Published: January 2022

Changes in ecosystem water use efficiency (WUE) and evapotranspiration (ET) that are driven by vegetation change can be used as metrics to quantify ecosystem carbon and water exchange. The effect of vegetation on WUE has been explored in the past through consideration of total ET. However, interception (Ei) doesn't directly participate in ecosystem carbon and water exchange, and uncertainty of modeled Ei, resulting in great uncertainty of ET partitioning and ecosystem WUE. Here, we estimated Ei in China using Gerrits' model, replacing the algorithm for Ei in the Priestley‐Taylor Jet Propulsion Laboratory (PT‐JPL) model. The modified PT‐JPL model was then incorporated into the analytical WUE model to estimate WUE over China for 2003–2011, and the results were validated against literature data (WUELiterature). To evaluate the net effect of vegetation restoration on WUE, we simulated WUE in three ways: with vegetation change; without vegetation change; and with vegetation change, but without any Ei changes caused by vegetation changes. In the study presented here, we demonstrate the WUE simulated by the analytical WUE model is significantly correlated with the WUELiterature (R2 = 0.76, p‐value < 0.001), and leaf area index contributes the most to the spatial variability of Ei/ET, ranging from 10% to 55%. Increased Ei weakened the effect of vegetation change on WUE by ∼51.3% during vegetation restoration in China; a reduction that was particularly marked in southern China. These findings highlight the importance of considering Ei when assessing the effects of vegetation change on ecosystem carbon and water exchange, and provide insights that are important for the sustainable management of vegetation change in China.
Tephra Fallout Probabilistic Hazard Maps for Cotopaxi and Guagua Pichincha Volcanoes (Ecuador) With Uncertainty Quantification
Authors: Tadini A. , Azzaoui N. , Roche O. , Samaniego P. , Bernard B. , Bevilacqua A. , Hidalgo S. , Guillin A. , Gouhier M.
Published: January 2022

Tephra fallout hazard assessment is undertaken with probabilistic maps that rely on numerical models. Regarding maps production, the input parameters of the model (including atmospheric conditions), the physical approximations of the numerical simulations, and the probabilities of occurrence of different eruption types in specific time frames are among the most critical sources of uncertainty. We therefore present a tephra fallout hazard assessment study for two active volcanoes (Cotopaxi and Guagua Pichincha) in Ecuador. We utilize PLUME‐MoM/HYSPLIT models, and a procedure for uncertainty quantification where: (a) the uncertainty on eruptive source parameters and eruption type occurrence is quantified through expert elicitation; (b) we implement a new procedure for correlations between the different parameters, and (c) we use correction coefficients to take into account the uncertainty of the numerical model. Maps of exceedance probability given a deposit thickness threshold, and thickness maps given a probability of exceedance, are produced (a) for two eruptive scenarios (sub‐Plinian and Plinian) and (b) as a combination of these scenarios in case the next eruption will be sub‐Plinian or Plinian. These maps are described according to the uncertainty distribution of eruption type occurrence probabilities, considering their 5th percentile, mean, and 95th percentile values. We finally present hazard curves describing exceeding probabilities in 10 sensitive sites within the city of Quito. Additional information includes the areal extent and the population potentially affected by different isolines of tephra accumulation. This work indicates that full uncertainty quantification helps in providing more robust scientific information, improving the hazard assessment reliability.
Variability and Dynamics of Along‐Shore Exchange on the West Antarctic Peninsula (WAP) Continental Shelf
Authors: Wang Xin , Moffat Carlos , Dinniman Michael S. , Klinck John M. , Sutherland David A. , Aguiar‐González Borja
Published: January 2022

The continental shelf of the West Antarctic Peninsula (WAP) is characterized by strong along‐shore hydrographic gradients resulting from the distinct influences of the warm Bellingshausen Sea to the south and the cold Weddell Sea water flooding Bransfield Strait to the north. These gradients modulate the spatial structure of glacier retreat and are correlated with other physical and biochemical variability along the shelf, but their structure and dynamics remain poorly understood. Here, the magnitude, spatial structure, seasonal‐to‐interannual variability, and driving mechanisms of along‐shore exchange are investigated using the output of a high‐resolution numerical model and with hydrographic data collected in Palmer Deep. The analyses reveal a pronounced seasonal cycle of along‐shore transport, with a net flux (7.0 × 105 m3/s) of cold water toward the central WAP (cWAP) in winter, which reverses in summer with a net flow (5.2 × 105 m3/s) of Circumpolar Deep Water (CDW) and modified CDW (mCDW) toward Bransfield Strait. Significant interannual variability is found as the pathway of a coastal current transporting Weddell‐sourced water along the WAP shelf is modulated by wind forcing. When the Southern Annual Mode (SAM) is positive during winter, stronger upwelling‐favorable winds dominate in Bransfield Strait, leading to offshore advection of the Weddell‐sourced water. Negative SAM leads to weaker upwelling‐ or downwelling‐favorable winds and enhanced flooding of the cWAP with cold water from Bransfield Strait. This process can result in significant (0.5°C below 200 m) cooling of the continental shelf around Palmer Station, highlighting that along‐shore exchange is critical in modulating the hydrographic properties along the WAP.
A Qualitative Study to Inform Development of a Behavioral Intervention to Promote Food Allergy Self-Management and Adjustment Among Early Adolescents
Authors: Herbert Linda Jones , Cooke Frances , Ramos Ashley , Miller Emily , Padgett Shaylar , Green Todd D.
Published: January 2022

Objective:

Adolescence is a high-risk period for patients with food allergy (FA) as management responsibilities shift to the youth. This study used qualitative methods to explore FA experiences among a diverse pediatric FA population and inform behavioral intervention development.

Method:

A total of 26 adolescents ages 9–14 years with IgE-mediated FA ( M age = 11.92 years; 62% male; 42% Black, 31% White, 12% Hispanic/Latinx) and 25 primary caregivers ( M age = 42.57 years; 32% annual income > $100,000) were recruited from FA clinics to complete separate qualitative interviews about FA-related experiences. Interviews were audio-recorded, transcribed, and entered into Dedoose, a qualitative software program. A grounded theory qualitative analytic approach was used to analyze data.

Results:

Emergent themes include: (a) FA is a chronic burden that affects daily life, (b) Families experience anxiety about FA, (c) Families find it challenging to transition FA management from parent to child, (d) FA families feel the need to be prepared, (e) FA families frequently advocate for their needs, and (f) Social experiences affect the FA experience.

Conclusions:

Adolescents with FA and their caregivers experience daily stress related to their chronic illness. A behavioral intervention that provides FA education, bolsters stress/anxiety management, assists parents in transitioning FA management responsibility to the youth, teaches executive functioning and advocacy skills, and fosters peer support could help adolescents successfully cope with and manage FA in their daily lives.

Implications for Impact Statement

Findings from this research project contribute to a growing body of literature that indicates adolescents with FA would benefit from support managing their FAs and identified specific FA experiences that should be addressed in a behavioral intervention for this population.
Xq27.1 palindrome mediated interchromosomal insertion likely causes familial congenital bilateral laryngeal abductor paralysis (Plott syndrome)
Authors: Boschann Felix , Moreno Daniel Acero , Mensah Martin A. , Sczakiel Henrike L. , Skipalova Karolina , Holtgrewe Manuel , Mundlos Stefan , Fischer-Zirnsak Björn
Published: January 2022

Bilateral laryngeal abductor paralysis is a rare entity and the second most common cause of stridor in newborns. So far, no conclusive genetic or chromosomal aberration has been reported for X-linked isolated bilateral vocal cord paralysis, also referred to as Plott syndrome. Via whole genome sequencing (WGS), we identified a complex interchromosomal insertion in a large family with seven affected males. The 404 kb inserted fragment originates from chromosome 10q21.3, contains no genes and is inserted inversionally into the intergenic chromosomal region Xq27.1, 82 kb centromeric to the nearest gene SOX3. The patterns found at the breakpoint junctions resemble typical characteristics that arise in replication-based mechanisms with long-distance template switching. Non protein-coding insertions into the same genomic region have been described to result in different phenotypes, indicating that the phenotypic outcome likely depends on the introduction of regulatory elements. In conclusion, our data adds Plott syndrome as another entity, likely caused by the insertion of non-coding DNA into the intergenic chromosomal region Xq27.1. In this regard, we demonstrate the importance of WGS as a powerful diagnostic test in unsolved genetic diseases, as this genomic rearrangement has not been detected by current first-line diagnostic tests, i.e., exome sequencing and chromosomal microarray analysis.