bluuebunny/crossref_metadata_2025 huggingface dataset:
La prescription des biothérapies en Tunisie au cours des rhumatismes inflammatoires chroniques
Authors: Zrour Saoussen , Dridi Amani , Grassa Rim , Ben Chekaya Narimane , Bejia Ismail
Published: January 2025

Objectifs : Analyser les caractéristiques de la prescription des biothérapies (bDMARDs) au cours des rhumatismes inflammatoires chroniques (RIC), pris en charge par la Caisse Nationale d'Assurance Maladie (CNAM) en Tunisie, estimer son coût direct et les facteurs qui en sont associés.
Méthodes : Cent neuf dossiers, consécutifs, de première prescription ou de rotation de bDMARDs, de Janvier à Juin 2022, ont été inclus. Les paramètres cliniques, thérapeutiques et déterminant le choix, ont été collectés. Les coûts mensuels de bDMARDs ont été calculés.  Le surcoût est défini par un coût dépassant 2200 dinars Tunisien (DT) par mois par patient.
Résultats : Le RIC était, essentiellement, une spondyloarthrite axiale (SA) dans 44% et une polyarthrite rhumatoïde (PR) dans 37,6% des cas. L’arthrite idiopathique juvénile représentait 2,7% des cas.  Les bDMARDs était prescrits majoritairement dans les régions côtières, suivant la répartition des rhumatolgues. Le certolizumab pégol était le plus prescrit dans 45% des cas. Les dépenses mensuelles totales en bDMARDs sont estimées à 225 535 ± 1269 DT. Aucune association significative n’était observée entre le choix de la molécule de bDMARDs et les caractéristiques des patients, ni des RIC, ni des prescripteurs. Le surcoût était associé de façon significative au DAS28 initial élevé lors de la PR et à l’âge jeune et la prothèse totale de la hanche au cours de la SA.
Conclusion : En Tunisie, la prescription des bDMARDs est inégale en fonction des régions et entraine un coût élevé. Le RIC le plus fréquemment traité est la SA.
Chronic immune thrombocytopenic purpura in children : Clinical presentations and management
Authors: Maaloul Ines , Kolsi Roeya , Chaari Mourad , Ben Ameur Salma , Aloulou Hajer , Kamoun Thouraya
Published: January 2025

Objective: the aim of this study is to report epidemiological data, clinical presentations and management of chronic immune thrombocytopenic purpura  (ITP)  in a single center in south of TUNISIA.
Methods: retrospective study collecting all cases of chronic ITP among children aged less than 14 years, in a department of pediatrics in south of Tunisia during a period of 13 years (from 1st January 2010 to 31 December 2022)
Results: during the study period, 72 newly diagnosed ITP were recorded; 11 patients evolves chronic ITP (12 ,5%). They were 6 boys and 5 girls.   Two patients were aged more than 10 years at the onset of the disease.  Symptoms in the chronic stage were mucocutaneous bleeding. One patient developed post traumatic cerebral hemorragia.  Three patients had severe form, and required second-line therapy. Two patients requested Eltrombopag  with good response.
One patient had spontaneous recovery after 3 years of follow up.
Conclusion: Management of chronic ITP represents a real challenge for pediatrician. Currently, there are some recommendations and guidelines which can guide management strategy of severe forms of Chronic ITP.
Assessment of body mass index, lifestyle and health perception among female university students in Morocco
Authors: Rahim Souad , Mohtadi Karima
Published: January 2025

Objective: The objective of this study was to assess the relationship between Body Mass Index (BMI), dietary habits, physical activity, and health perception among female university students in Morocco.
Methods: The study was conducted at a Moroccan university among female students from the Faculty of Sciences Ain-Chock in Casablanca. Participants were given a self-administered questionnaire that evaluated sociodemographic factors, dietary habits, food group consumption, physical activity, and self-assessed health status. Data collection took place from February 2023 through the end of April 2023.
Results: A total of 335 students aged 18 to 29 years participated in the survey. The study revealed that 72.5% of the participants were within the normal weight range (BMI 18.5-24.9 kg/m²), while 15.9% were classified as overweight and 3.9% as obese. Additionally, 47.9% of the participants engaged in physical activity, with 30.2% dedicating more than 45 minutes to their activities. The  health perception was found to be related to weight classification, with poor health perception most commonly associated with the "18.5-25" BMI range (57.8%).
Conclusion: The study sheds light on the intricate interaction between weight, health, and lifestyle in Morocco. The frequency of normal-weight persons and active participation indicates university students' health awareness. The prevalence of overweight and obesity, on the other hand, need ongoing health measures. These findings help to build focused methods for promoting healthier lives in Morocco, utilizing educational institutions as health promotion platforms.
Surpoids et Obésité chez des Enfants Scolarisés : Prévalence et facteurs associés
Authors: Mahjoub Faten , Ben Amor Nadia , Rachdi Rim , Mizouri Ramla , Zaier Amani , Jamoussi Henda
Published: January 2025

Introduction : L’obésité de l’enfant, véritable épidémie mondiale, est une pathologie multifactorielle d’origine génétique et environnementale.
Objectifs : Déterminer la prévalence du surpoids chez des écoliers dans la région du Bardo (délégation citadine du gouvernorat du grand Tunis) et étudier les facteurs associés à la surcharge pondérale.
Méthodes : Etude transversale descriptive ayant concerné des élèves âgés de 10 à 12 ans. Un interrogatoire, des mesures anthropométriques et une enquête alimentaire ont été réalisés. Selon les courbes de corpulence de l’International Obesity Task Force (IOTF) en fonction du genre, un Indice de Masse Corporelle (IMC) chez l’enfant ≥ 97ème percentile définissait le surpoids, et un IMC ≥ IOTF-30 définissait l’obésité.
Résultats : L’âge moyen des 105 élèves était de 10,8±0,5 ans. L’IMC moyen était de 19,68±3,86 kg/m². La fréquence de la surcharge pondérale était de 35,3%. Le surpoids touchait 45% des filles et 29,2% des garçons. La prévalence de l’obésité était de 8,6% (7 garçons et 2 filles). 55,6% des filles et 47,4% des garçons en surpoids avaient une alimentation hypercalorique. La prise des repas devant la télévision a été rapportée chez 40,5% des élèves en surpoids versus 19,4% des élèves normo-pondéraux. L’hyperphagie prandiale multiplie le risque de surpoids de 18,48 (p=0,0001). L’obésité parentale multiplie de 2,69 le risque de surcharge pondérale chez leur progéniture (p=0,023).
Conclusion : En plus de l’héritabilité génétique, les enfants partagent des habitudes alimentaires avec leurs parents. De ce fait, la prise en charge basée sur les mesures hygiéno-diététiques doit intéresser toute la famille.
From Thesis to Publication: Unveiling the Predictive Factors for Cardiology Research at a North African Faculty of Medicine (Tunisia)
Authors: Yahia Faten , Gazzeh Hamza , Ben Mansour Fares , Zanina Youssef , Neffati Elyes , Ben Abdelaziz Ahmed
Published: January 2025

Introduction: The benchmark of a medical thesis’ success is often its acceptance for publication in an indexed journal.
Aim: To determine the publication rate of practice theses in the field of Cardiology at the Faculty of Medicine of Sousse (FMSo) in Tunisia and to identify predictive factors for successful publication.
Methods: We conducted a descriptive bibliometric analysis of Cardiology theses defended at FMSo from 2000 to 2019. Data were extracted from the theses’ cover pages, abstracts, and conclusions. The publication status was ascertained via searches in “MEDLINE”, “Scopus”, and “Google Scholar”. Predictive factors for publication were identified using multivariate analysis with a 90% Confidence Interval (CI).
Results: Of the 111 Cardiology theses defended at FMSo between 2000 and 2019, 36 were published yielding 42 scientific articles (publication rate of 32%). Notably, 86% of these articles were indexed in “MEDLINE” and/or “Scopus”. In 79% of cases, doctoral candidates were co-authors of the resultant publications. Publication was significantly influenced by three factors: scientific mentorship by an Assistant or Associate Professor (aOR=3.021; 90%CI: 1.06-10.14; p=0.082), a prospective study design (aOR=2.536; 90%CI: 1.07-6.02; p=0.076), and a satisfactory quality of writing (aOR=2.384; 90%CI: 1.11-5.11; p=0.061).
Conclusion: The publication of Cardiology theses at FMSo was found to be associated with the prospective design of the study and the quality of writing. Thus, it is imperative to enhance the research methodology and scientific communication skills of medical thesis candidates and their mentors to facilitate the transition from academic dissertations to medical articles.
COVID-19 is more likely to be complicated by autoimmune encephalitis than PRES
Authors: Finsterer Josef , Mehri Sounira
Published: January 2025

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Foreign body ingestion in children: Clinical features and complications
Authors: Trabelsi Ines , Kbaier Soumaya , Daoued Yasmine , Lachiheb Asma , Brini Ines , Khalsi Fatma , Boussetta Khedija
Published: January 2025

Introduction : The ingestion of foreign body (FB) is a common problem in paediatrics. Children are curious by nature and tend to explore environment by inserting objects into their mouths. 
Aim: To update our epidemiological and clinical data and adapt clinical management in order to limit morbidity associated with this fairly frequent accidental pathology.
Methods: Retrospective descriptive study including children aged less than 15 years, hospitalized in the Children's Medicine Department B of the Tunis Children's Hospital from 1 January 2016 to 31 December 2021 having ingested a FB.
Results : Forty-four children were included and admitted for foreign body ingestion,  with a sex ratio of 1.4. The mean age was 4 years 4 months. Most children were asymptomatic on admission. In the others, digestive forms predominated (n=19). The average consultation time was 10.8 hours. The FBs were mainly foams and corrosives (75%), represented by batteries in 52% of cases and coins in 22% of cases. Thoraco-abdominal X-rays carried out on all patients revealed a radio-opaque foreign body in 95% of cases. The most frequent location was the colon (n=17). Endoscopy was chosen in 14 patients and was extractive in five. The mean time from admission to endoscopic extraction was 10.6 hours. The mean time to expulsion by natural route was 49 hours. Complications were noted in two patients: ulceration of the oesophageal mucosa and dyspnoea following rigid endoscopy in one case. 
Conclusion : This study has shown that the ingestion of foreign body  ...( abstract truncated at 250 words)
Evaluation of pediatric cochlear implantation results
Authors: Bouatay Rachida , Koubaa J , Yahyaoui M , Bouaziz N , Ferjaoui M , El korbi A , Kolsi N , Harrathi K , Zrig A
Published: January 2025

Background: Cochlear implantation is an effective method of auditory rehabilitation. Nevertheless, the results show individual variations depending on several factors.
Aim: To evaluate cochlear implantation results based on the APCEI profile (Acceptance, Perception, Comprehension, Oral Expression and Intelligibility) and audiometric results.
Methods: This was a cross-sectional study including children under 18 years of age who had a unilateral cochlear implant and whose implants had been activated at least 1 year prior to the start of the study. During this study period, 75 children underwent unilateral cochlear implantation. Among them, 44 patients had reached one year after the activation of the implant at the time of the evaluation and were then included in the analytical part. A speech-language pathology assessment using the APCEI scale was conducted for 44 cases. Thirty-eight cases had an audiometric assessment (free-field tone audiometry and speech audiometry).  We assessed the results of the APCEI profile based on various factors.
Results: The mean cochlear implantation age was 5 years and 2 months. The electrode insertion was complete in all cases. The APCEI profile average was 3.6. Four children had poor results, 27 children had good results, and 13 children had excellent results. The average hearing threshold in tonal audiometry was 39dB. In voice audiometry, the average intelligibility threshold was 65% with the cochlear implant versus 75% with the cochlear implant and the contra lateral hearing aid. According to the statistical study, only two factors were considered to have a positive influence ..(abstract truncated at 250 words)
Urinary Cytology: The DxU-850 Iris automaton versus Microscopic Examination
Authors: Lekfif Hasnae , Saddari Abderrazak , Ezrari Said , Idrissi Amjad , Benaissa Elmostafa , Ben Lahlou Yassine , Elouennass Mostafa , Maleb Adil
Published: January 2025

Introduction: The use of urine cytobacteriological examination is a common and essential practice in medicine which helps guide therapeutic management in case of urinary tract infection. The cytological examination of urine samples can be done using the manual (microscopic) or automated technique. The automated approach, which involves the use of artificial intelligence, is faster, more reliable, and more efficient for laboratories.
Aim: This work aims to evaluate the performance of the DxU-850 Iris automate by comparing it to the microscopic method.
Methods: Using a four-month prospective study from May to August 2023, we analyzed urine samples received during this period by the Microbiology laboratory of Mohammed VI University Hospital in Oujda. Strict quality standards were respected when obtaining the results. Several elements were analyzed, and various parameters calculated to evaluate the performance of this automaton.
Results: The present study investigated 1000 CBEU samples, mainly from outpatient clinics (46.34%) and emergency departments (21.72%). Most patients were males (50.58%) and asymptomatic (72.9%). The samples’ culture showed varied results: concordance between the results of automaton and microscopic count was satisfactory except for crystals and yeasts in turbid samples.
Conclusion: Automation has advantages like speed, traceability, error reduction, and time optimization. The results reveal a satisfactory concordance between the two methods despite discordances occurring mainly with crystals and yeasts, especially in turbid urine samples. The DxU-850 Iris automaton is an effective way to screen for urinary tract infections. We recommend that automated and manual techniques be considered complementary.
AN OVERVIEW OF CURENT SITUATION OF SCIENTIFIC AND RESEARCH WORK IN BIH
Authors: Žilić Lejla , Lisica Alan
Published: January 2025

Scientific research work is an activity or a kind of process that has its result. Quality and adequate scientific research results contribute to the emergence and spread of an innovative society based on knowledge and significantly affect the socio-economic development of the country. This paper presents the current situation regarding scientific research in B&H with detailed information. The aim of this paper is to show the importance
of scientific research for society as a whole, to show the degree of utilization of the potential that B&H has and to point out current problems.
Prediction of Groundwater Sustainability and Land Subsidence in the Toluca Aquifer System, Mexico
Authors: Gárfias Soliz Jamie , Calderhead Angus , Castellazzi Pascal
Published: January 2025

Rapid population growth in the Toluca Valley region has led to an increasing demand on the available water resources. The groundwater overexploitation has resulted in a systematic decline of the groundwater levels, the disappearance of artesian springs and wetlands, as well as land subsidence and earth fissuring within the watershed. To address these concerns, this book compiles 20 years of research aiming to establish guidelines for the sustainable management of the Toluca aquifer system.

This book provides readers a better understanding of the consequences of continued pumping of the Toluca aquifer, given the trends of groundwater exploitation. The reader will find hydrogeological and hydrological tools, as well as analysis of multilevel monitoring wells, recharge, groundwater withdrawal and natural discharge data, that were used to better understand the groundwater budget and the evolution of groundwater-level declines to estimate its availability and future deficit. This book shows that a multi-disciplinary approach based on a coupled groundwater flow and aquifer deformation model, hydraulic heads time-series, borehole extensometers measurements and InSAR interferometry data, is useful to assess the sustainability of groundwater resources in aquifers subject to compaction. This study emphasizes the importance of achieving a balance between water pumping and natural rates of recharge and providing better protection of key recharge areas from actual and future land use changes. The declining groundwater levels in the Toluca aquifer system are a challenge for water resource managers and stakeholders that wish to minimize the risks to human and infrastructure while maximizing the beneficial use of the groundwater resources.
Perancangan Sistem Informasi E-Voting Berbasis Web Untuk Pemilihan Ketua Himpunan Di UIN Sumatera Utara Medan
Authors: Ardi  Pradana Surya , Reza Andika  , M Arif Panji Wibowo  , Muhammad Rindhu Samora Hutagalung  , Halin Khoirot Sipahutar  , Chairul Rizal
Published: January 2025

Penelitian ini dilatarbelakangi oleh perkembangan teknologi yang memudahkan seleksi dalam pemilihan ketua himpunan mahasiswa yang selama ini dilakukan secara manual. Metode manual ini memiliki beberapa kelemahan, antara lain yaitu penghitungan suara lambat, penghitungan suara salah, tidak ada salinan surat suara saat rusak, kesulitan penghitungan ulang saat penghitungan suara tidak dipercaya, kerentanan terhadap konflik dan anggaran tinggi, dan dampak lingkungan dari penggunaan kertas sebagai media pemungutan suara. Oleh karena itu, tujuan penulis adalah mengembangkan sistem pemungutan suara pemilihan ketua himpunan mahasiswa secara online yang memudahkan penyelenggaraan pemilihan, meminimalkan efisiensi waktu produktivitas belajar mahasiswa di kampus, dan mengurangi jumlah hasil pemilihan yang rusak. Perancangan ini menggunakan framework codeigniter 3 dengan bahasa pemrograman PHP dan MySql sebagai databasenya. Metode yang dipakai pada perancangan ini menggunakan metode Waterfall. Sistem ini diharapkan dapat membantu dan mempermudah serta mempercepat proses pemilihan Ketua Himpunan Program Studi Sistem Informasi UIN Sumatera Utara.
INDIGENOUS CANNABIS SATIVA - THE PHARMACOGNOSTICAL ANALYSIS OF A WEED-TYPE VARIETY
Authors:   Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania, Olar Diana , Boda Francisc ,   Department of General and Inorganic Chemistry, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania, Tero-Vescan Amelia ,   Medical Chemistry and Biochemistry Department, Faculty of Medicine in English, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania
Published: January 2025

Cannabis sativa is a well-known plant that has attracted a lot of attention because of its remarkable therapeutic potential. However, a variety of this species is growing invasive in some cultures in Romania. This variety has a different composition compared to the cultivated variety and a notably low Δ9- tetrahydrocannabinol (THC) content, making the occurrence of psychoactive effects highly improbable. This research aimed to evaluate from a pharmacognostical point of view the herbal drug collected from Romania. A preliminary microscopic analysis was performed to confirm the identity of the herbal drug. A qualitative analysis by thin-layer chromatography was performed to identify cannabinoids and flavonoids. Quantitative determinations included the evaluation of total polyphenolic content, total flavonoid content, and hydroxycinnamic acid content, as well as ion chromatographic analysis for anion quantification. Antioxidant and alpha-amylase activities were performed as well. The results indicated that the herbal drug contains only moderate concentrations of polyphenolic compounds, but has a good antioxidant activity, likely attributable to the presence of non-polyphenolic compounds. Moreover, the extract had a moderate alpha-amylase inhibitory activity, suggesting a low potential in nutritional and therapeutic contexts.
EPIPACTIS TALLOSII A. MOLNÁR & ROBATSCH. (ORCHIDACEAE) IN TRANSCARPATHIA (UKRAINE): NEW DATA ON DISTRIBUTION AND ECOLOGY
Authors:   Ferenc Rákóczi II Transcarpathian Hungarian College of Higher Education, Ljubka Tibor , Hadnagy István ,   Ferenc Rákóczi II Transcarpathian Hungarian College of Higher Education, Tsarenko Olga ,   M.G. Kholodny Institute of Botany, National Academy of Sciences of Ukraine, 2 Tereschenkivska Str., Kyiv 01004, Ukraine
Published: January 2025

In this publication, generalized information on the geographical distribution and ecological affiliation of Epipactis tallosii A. Molnár & Robatsch. (Orchidaceae) in Ukraine, and the state of its populations is analysed. In 2016, the species was first observed in Transcarpathia, in the vicinity of the village Nove Selo. Later, in 2020-2021 we found three new localities in the old floodplain willow-poplar forest (association Salici-Populetum (Tx. 1931) Meijer-Drees 1936) on the banks of the Borzhava river near villages of Bene and Kvasovo (Beregovo district). The article describes the ecology and habitat of the species in the study region.
Should Turkiye Adapt USD as its Domestic Currency?
Authors:   California State University Domiguez Hills, Ilter Cenap
Published: January 2025

Dollarization is visible in developing countries that are prone to high inflation and local currency
devaluation against hard currencies. Market makers demand hard currencies as store of value and
distance themselves from local currency. Over the years, worn out due to continuous devaluations and
high inflation, countries convert their local currencies to hard currencies either through official
conversion or adopting it by market makers and public in general. Dollarization has been underway for
a long time in Turkiye. In its economic history there has been many devaluations and high inflations. Its
currency is no longer a store of value. The paper explores two alternatives. One is establishing a
currency board and the second being if the USD can be a replacement currency for TL. It concludes
that replacing TL with USD will be the best solution for Turkiye`s continued economic downturns. Along
with currency replacement, should come the government savings and borrowing from IMF as part of
the suggested solution.
The Use of Financial Technologies in Promoting and Providing Services in the Financial Intermediation Industry
Authors:   George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Spătăcean Ioan Ovidiu , Todoran Dorinel-Vasile ,   George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures
Published: January 2025

The research explores the use of technology in the financial intermediation industry and capital
markets, highlighting the mutually developing relationship and the impact of technological innovations
in democratizing access to financial markets and increasing transaction efficiency. The study highlights
the advancement of the Fintech sector, which, through solutions such as trading bots, blockchain and
artificial intelligence, is significantly improving financial services. While the implementation of new
technologies opens up profit opportunities, it requires detailed analysis and careful risk management.
Research also reveals investors' appetite for fintech tools, including artificial intelligence, but they
prefer to retain direct control over investment decisions.
A CASE REPORT ON AYURVEDIC MANAGEMENT OF TYPE 2 DIABETES MELLITUS
Authors: FARSEENA K  , SHAILESH DESHPANDE
Published: January 2025

Diabetes mellitus is a multifactorial metabolic disorder with increasing prevalence, contributing significantly to the global health burden. Given its impact on multiple organ systems, emphasis on prevention, early detection, and appropriate management is crucial. This case report presents a 56-year-old male patient with a 10-year history of diabetes, previously managed with allopathic medication, who sought consultation at the OPD of Government Ayurveda College Hospital, Kannur, Kerala. The patient presented with complaints of increased frequency of urination, excessive thirst, fatigue, foul-smelling sweat, oedema in the feet, and burning micturition. A comprehensive evaluation of the patient’s clinical condition, including an assessment of dosha, dooshya, and srothas, led to the administration of a Kapha-Medohara treatment protocol. This Ayurvedic intervention resulted in significant improvement in the patient's symptoms, highlighting the potential of integrative approaches in managing chronic metabolic disorders like diabetes.
CLINICAL AND INSTRUMENTAL MARKERS OF COMPLICATED COURSE OF INFECTIOUS-INFLAMMATORY DISEASES IN EXTREMELY PREMATURE NEWBORNS
Authors: PRYLUTSKAYA V.A. , PRYSTROM I.Y. , BOIDAK M.P. , ULEZKO E.A. , SVIRSKAYA O.A. , KOROL-ZAKHAREVSKAYA E.L.
Published: January 2025

The study evaluated clinical parameters of 74 premature newborns, as well as the results of laboratory and instrumental methods for diagnosing congenital infection. Statistically significant differences between groups were found in gestational age, birth weight, Apgar score, and results of laboratory and instrumental studies, including platelet levels and markers of inflammation. When assessing diagnostic accuracy, interleukin-6 had the most pronounced 351 diagnostic value on the 1st day, and procalcitonin on the 3rd-5th days. Brain neurosonography revealed more frequent periventricular edema and morphological changes in Group 1. Abdominal ultrasound also showed more frequent visible pathology in Group 1.
Key themes of resiliency, outsourcing and third-party risk management regimes
Authors: Pierides Mike , Mulligan James
Published: January 2025

Throughout 2024, European Union (EU)-based financial entities have been analysing their thirdparty and intra-group technology contracts against compliance with the EU Digital Operational Resilience Act (DORA), and renegotiating with vendors where necessary, in order to comply from 17th January, 2025. McKinsey estimates that EU institutions typically earmarked €5−15m for DORA programme strategy, planning and design, although full implementation costs may be five to ten times that range.1 The DORA analysis is also highlighting that certain companies are not compliant with existing regulatory expectations. Financial regulators and global standard-setting bodies have published high-level principles and also detailed expectations to ensure that companies have in place prudent third-party risk management controls, both at an enterprise level and for managing individual third-party arrangements. As securities markets participants become increasingly reliant on third-party service providers for tasks that they had not previously undertaken, leveraging technology and artificial intelligence (AI), supervisory focus is extending to operational resilience across third-party services relationships, not just outsourcing. In this paper, we explore key themes of existing outsourcing and third-party risk management regimes that apply to financial entities and their service providers. We note key differences between regulatory expectations on resiliency and outsourcing, highlight key best practices and challenges to implementing these expectations and, finally, consider the impact of AI solutions on such regulatory expectations.
Integrating private assets in a total portfolio approach
Authors: Meyer Thomas
Published: January 2025

In a total portfolio approach (TPA) asset owners use their entire capital to maximise the net impact of their investments by diversifying over risk factors. The focus is on allocation to risk exposures rather than asset classes, as in the traditional strategic asset allocation (SAA). Compared to the SAA, the TPA leads to better quality of decision making by using a factor lens that embraces the continuum between equity and debt as well as across public and private markets. The increasing adoption of the TPA coincides with what has even been termed ‘hypergrowth’ of investing in private markets. Many asset owners may be overestimating their liquidity needs and thus be foregoing valuable opportunities for investing in private assets and harvesting an illiquidity premium. As the costs of illiquidity do not depend on the asset but the specific state of a portfolio, TPA requires frequently generated cash flow forecasts for investments in these illiquid assets. By following the TPA and by treating private assets on an equal footing to liquid asset classes, asset owners can construct their portfolios in a new and innovative way that has the potential to sustainably generate higher returns. Newer risk factor models in combination with highly automated cash flow forecasting tools create a unifying framework whereby risks are measured more realistically, and a private asset’s illiquidity is not penalised if no liquidity is needed within the portfolio’s context.
A AÇÃO POPULAR E SUA EFICÁCIA SOCIAL PARA O EXERCÍCIO DA CIDADANIA E O FORTALECIMENTO DA DEMOCRACIA
Authors: Farah João Pedro Vieira
Published: January 2025

Entre os remédios constitucionais previstos na legislação brasileira, a ação popular se destaca pela sua forte ligação com o princípio essencial da cidadania, sendo uma forma de exercício da soberania popular. Originária do Direito Romano, surgiu como um instrumento jurídico para proteger a moralidade administrativa, sendo reintegrada na primeira Constituição brasileira em 1824, após mais de mil anos de obscuridade. Ao longo do tempo, evoluiu para também proteger direitos difusos e coletivos, como a preservação do meio ambiente e do patrimônio cultural. Após uma análise detalhada das características e da história da ação popular. A problemática central é o impacto real da ação popular, questionando como o cidadão brasileiro médio utiliza esse mecanismo constitucional, se seu uso é difundido e eficaz, e quais as razões socioculturais que podem explicar a baixa penetração desse dispositivo entre as camadas populares. A conclusão alcançada é que, embora a ação popular possua plena eficácia jurídica, sua efetivação social ainda é limitada, evidenciada pela baixa quantidade de ações desse tipo propostas ao Judiciário.
Comprehensive Histopathological Properties of Dartos Tissue Associated with Hypospadias Severity and Chordee: A Prospective Study
Authors: Raharja Putu Angga Risky , Birowo Ponco , Rachmadi Lisnawati , Wibowo Heri , Kekalih Aria , Duarsa Gede Wirya Kusuma , Wahyudi Irfan
Published: January 2025

Background: The cause of chordee in hypospadias is not fully understood. Dartos fascia resection has been shown to correct penile curvature, suggesting its potential involvement. This study aimed to evaluate the histopathological properties of dartos tissue and their association with hypospadias severity and chordee.Methods and Materials: Dartos tissue samples were collected from 37 children with hypospadias and ten controls undergoing circumcision between March and October 2024. Histopathological analysis using hematoxylin-eosin and Masson’s trichrome staining assessed for collagen, smooth muscle, and vascular density. Assessment and quantification of all histopathological components were blinded. Results: The hypospadias group showed lower collagen density (60.85±6.75% vs. 67.31±4.61%; p=0.003) and higher smooth muscle density (7.34±4.92% vs. 2.51±2.24%; p<0.001) compared to controls, with no significant difference in vessel density. Sub-analysis showed severe chordee was linked to lower collagen density compared to mild (Mean Difference [MD] -6.24±2.41%; p=0.014) and moderate chordee (MD -5.73±2.54%; p=0.031). Conclusions: The dartos tissue in hypospadias patients exhibited lower collagen density and higher smooth muscle density, with chordee severity specifically linked to decreased collagen density.
Síndrome de Burnout em profissionais da saúde: Fatores de risco e estratégias de prevenção no ambiente de trabalho sob a perspectiva da medicina do trabalho
Authors: Lippe Marcela Maria Ferreira
Published: January 2025

O burnout em profissionais da saúde é um desafio relevante para a saúde ocupacional, caracterizado por exaustão emocional, despersonalização e baixa realização profissional. Esse quadro resulta de estressores crônicos no ambiente de trabalho, como jornadas prolongadas, alta demanda emocional e falta de suporte organizacional, afetando a saúde mental e física dos trabalhadores e comprometendo a qualidade do atendimento ao paciente. Este estudo teve como objetivo analisar os fatores de risco e as estratégias de prevenção do burnout, com foco nas intervenções da Medicina do Trabalho para promover ambientes laborais saudáveis. Foi realizada uma revisão integrativa da literatura nas bases PubMed, SciELO, LILACS e Google Scholar, abrangendo publicações de 2010 a 2024. Os resultados destacam que intervenções organizacionais, como a melhoria do ambiente de trabalho, apoio da liderança e equilíbrio entre vida pessoal e profissional, são eficazes na prevenção do burnout. Estratégias individuais, como programas de saúde mental e práticas de mindfulness, também são importantes. Conclui-se que o enfrentamento do burnout exige uma abordagem multidisciplinar, combinando medidas organizacionais e individuais. A Medicina do Trabalho é essencial na identificação precoce de riscos e na implementação de estratégias preventivas. Contudo, mais estudos são necessários para aprimorar as práticas de prevenção e manejo, garantindo maior segurança e bem-estar aos profissionais de saúde.
Internet of Things (IoT) Cybersecurity Enhancement through Artificial Intelligence: A Study on Intrusion Detection Systems
Authors: Sadaram Gangadhar , Sakuru Manikanth , Karaka Laxmana Murthy , Reddy Mohit Surender , Bodepudi Varun , Boppana Suneel Babu , Maka Srinivasa Rao
Published: January 2025

Computers networks are very vulnerable and can be threatened by hackers, viruses and other immoral entities. Intrusion detection is a crucial component of network security since it is an active defence technique. limited accuracy, limited detection effectiveness, high false positive rate, and incapacity to deal with new forms of intrusions are some of the challenges faced by traditional intrusion detection methods. These problems may be solved by suggesting a real-time network intrusion detection system that uses ML. With the use of the CICIDS2017dataset, which contains both benign traffic and a range of attack types, this research introduces an Intrusion Detection System (IDS) intended to improve IoT cybersecurity. For the selection of the features, which are important and are not numerous, PCA is applied. The SMOTE is a tool for addressing class imbalance. Among these models, DenseNet, KNN, SVM and DeepGFL are some of the models whose performances are measured compared with a set of performance metrics such as recall, accuracy, precision and F1-score. Therefore, DenseNet provides the highest level of efficiency and reliability for all of the research and development models proposed, with a perfect back-and-forth recall of 98.2%, accuracy of 99.12%, and precision of 98.6%. Therefore, the results confirm DenseNet’s applicability in detecting intrusions in IoT networks. In subsequent research, more attack types will be integrated into the dataset, and real-time integration will be considered, as well as using deep reinforcement learning for dynamism for threat detection at the IoT system level.
Predictive Modeling and Analysis in Genetic Diseases: A Comprehensive Review of Recent Advances
Authors: Hamad Rana Khalid
Published: January 2025

This paper provides a comprehensive analysis of current advancements in predictive modeling and genetic disease classification. We delve into various machine learning techniques and text mining technologies that have significantly contributed to understanding genetic disorders and extracting valuable information from vast unstructured data. Our literature review examines key studies from recent years that have utilized machine learning models, including Naive Bayes, support vector machines, and deep learning frameworks, to improve the predictive accuracy of genetic disease outcomes. This work is aimed at enhancing the framework for predicting complex diseases using advanced computational methods.
Innovative Marketing Approaches and Transformation of Slovenian Consumer Behavior During the COVID-19 Pandemic
Authors: Pucelj Maja , Shahid Muhammad Naeem , Ravikanth Regalla , Radwan Samah Adel Ibrahim Mohammed , Malik Muhammad , Hunt Anthony K.
Published: January 2025

The COVID-19 pandemic has presented unparalleled difficulties, requiring flexible and adaptive responses from both societies and enterprises. This study aims to analyze new marketing techniques and operational adjustments that have emerged in response to the global crisis, focusing on their impact on customer behavior and purchase choices. Utilizing an abductive paradigm with a sequential exploratory design, we combined qualitative and quantitative research approaches. We gathered data from a sample of 204 Slovenian respondents through an online survey, which underwent rigorous examination using structural equation modeling (SEM). Our findings reveal significant shifts in customer behavior, notably a transition towards online retail platforms. Education also appears to play a crucial role in influencing consumer behavior changes, especially within the pandemic's complex context. Additionally, changes in income distribution directly affect product demand dynamics in the market. The practical significance of this study is emphasized by the actionable suggestions it provides to policymakers and organizations. These recommendations equip them with the necessary understanding to effectively adjust their strategies to meet the changing demands and preferences of customers to prepare for future possible crises.
Democratization in Tunisia: Negotiating the Interplay of Policy and Economic Development
Authors: Selmi Noureddine
Published: January 2025

This study examines the implications of the Tunisian revolution in 2011 and its subsequent democratic evolution within the context ofprerequisites for democratic transition during the Arab Spring. The inquiry delves into two primary dimensions: firstly, an exploration of the objective rationales and contributing factors leading to the impediments in Tunisia’s democratic metamorphosis. This involves identifying the elements of foreign intervention and the political and social forces that have played a role in the setback, with specific emphasis on entities such as the Tunisian General Labor Union (UGTT), media outlets, civil society organizations, and influential entities within the bureaucratic administration. Secondly, the study seeks to assess the economic advancements that have fallen short of anticipated outcomes, evident in the decline across various economic indicators and the deteriorating socioeconomic landscape, foreshadowing an imminent economic crisis with profound social and security implications. The research contends that attributing the developmental setbacks, economic downturn, and insufficient economic progress alone cannot be solely accountable for impeding the trajectory of democratic transformation in Tunisia. It is imperative to also comprehend the pivotal role played by ideological conflicts and the inadequate consolidation of democratic culture.
Emotional and Social Intelligence and its Impact on the Business Success of Bulgarian Digital Entrepreneurs
Authors: Todorova Ana , Kostadinova Irina
Published: January 2025

The rapid development of digital technologies over the past two decades has created a new economic environment that requires continuous adaptation. However, paradoxically, increasing digitisation emphasises the importance of soft skills such as emotional and social intelligence. The present study aims to empirically analyse the relationship between these skills and the success of Bulgarian digital entrepreneurs. The results show that successful entrepreneurs demonstrate higher levels of emotional and social intelligence, with all its components – self-awareness, self-control, motivation, empathy and social skills – contributing significantly to en​trepreneurial success. The importance of optimism for overcoming challenges in a dynamic digital environment is particularly emphasised. The conclusion is that, despite the specific requirements of digital business, the basic profile of a successful en​tre​preneur remains universal and is characterised by high emotional and social intelligence. Therefore, this study adds value to the literature on entrepreneurship, management, organisational behaviour, and human resource management, while it can contribute to the development of assessment tools, as well as training and development programs for emotional and social intelligence.
The Impact Of Using Shopee Paylater On Student Consumptive Lifestyle Consumptive Lifestyle Of College Students
Authors: Rafidah Dita Dinar , Nurjaman Asep Rudi
Published: January 2025

The purpose of this research is first, to find out the use of paylater shopee among students, second, to find out the consumptive behavior of students, third, to find out the effect of using paylater shopee on student consumptive behavior. Like the Paylater in the Shopee application, you can immediately use it when selecting a payment method to use the Shopee feature with limits set by the application. Paylater Shopee is a paylater provider that can be used to pay for certain products, provided that the merchant must work with GoJek previously. The increasing level of online shopping with various payment options, especially the paylater that has been provided, has led to new lifestyle patterns and consumer behavior in online shopping habits.
COMPORTAMIENTO DE PARÁMETROS INFLAMATORIOS EN PACIENTES CON INFECCIÓN POR SARS-COV-2 EN EL PERÍODO 2020-2021
Authors: Villasmil Bastidas Saúl , Uribe Padrón José , Villasmil Bastidas Miriam , Duarte Luis , Acosta Perez Leonardo , Villamizar Aldana Blanca , Bustamante Siberio Yacelli
Published: January 2025

La COVID-19 es una enfermedad respiratoria aguda causada por la infección con el virus del síndrome respiratorio agudo coronavirus 2 (SARS-CoV-2). Algunos parámetros analíticos se han relacionado con la gravedad de la COVID-19 como el aumento de la proteína C reactiva (PCR), del dímero-D, la enzima lactato deshidrogenasa (LDH) y, hematológicamente, la linfopenia y desviación estándar del ancho de distribución de los glóbulos rojos (RDW). Se realizó un estudio retrospectivo de cohorte entre abril de 2020 y diciembre de 2021 donde se incluyeron a pacientes mayores de 18 años con sintomatología o sin ella, con diagnóstico COVID-19 para evaluar cada uno de estos parámetros durante la fase aguda. Los resultados muestran un aumento de todos los valores relacionados al proceso inflamatorio producido por la COVID-19, sin embargo, es interesante observar que algunos parámetros tienden a regresar a la normalidad pasada la fase aguda mientras otros pueden mantenerse elevados posterior a esta fase, incluso tiempo después de superada la fase de convalecencia. Nuestros resultados muestran una elevación y regreso a la normalidad de la LDH, así como un aumento moderado de la PCR, y un aumento en RDW y el Dímero D que se mantiene más allá de la fase aguda. Es importante destacar la necesidad de realizar nuevos estudios que ayuden a determinar los mecanismos moleculares involucrados en el mantenimiento de esta elevación para entender las implicaciones clínicas que podría tener y la posible relación con los efectos a largo plazo de la COVID-19.
ÍNDICES DE ANSIEDADE E DEPRESSÃO ASSOCIADOS AO NÍVEL DE ATIVIDADE FÍSICA DE ESCOLARES DO ENSINO MÉDIO
Authors: Gonçalves João Arthur Rodrigues , Oliveira Luís Felipe Lopes de , Benevides Andreia Cristina da Silva , Meneses Yúla Pires da Silveira Fontenele de
Published: January 2025

Comportamento sedentário em estudantes pode potencializar aspectos negativos como depressão, ansiedade e estresse. O objetivo deste estudo foi associar o nível de atividade física aos índices de ansiedade e depressão de escolares do ensino médio. Foi realizado um estudo descritivo, quantitativo e de corte transversal envolvendo uma amostra de 70 alunos do ensino médio de duas escolas privadas em Teresina-Pi. Os escolares respoderam a um questionário sociodemográfico e posteriomente, responderam ao questionário International Physical Activity Questionnaire – IPAQ, versão curta para estimar o nível de atividade física; e para verificar os dados dos índices de ansiedade e depressão utilizou-se a escala HAD - Hospital Anxiety and Depression Scale. Como resultado, 47,14% dos discentes eram do sexo masculino e 52,85% feminino. A média por idade prevalente foi de ≤16 anos. Percebeu-se que p-valores referentes a sexo, idade, ano escolar, os escolares pendem para os índices de ansiedade (p<0,05). Infere-se, portanto, que os estudantes avaliados, mesmo com a prática regular de atividades físicas apresentaram índices significativos de ansiedade. a relação ansiedade, depressão e atividade física não seguiu um padrão inversamente proporcional ao comportamento dos alunos.
Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria
Authors: Kapoor Yogita , Khurana Himani , Chakraborty Arnab , Dutta Debatri , Priya Anshu , Singh Archana , Kamat Siddhesh S , Dhar Neeraj , Pucadyil Thomas J , Nandicoori Vinay Kumar
Published: January 2025

The mycobacterial cytoskeletal protein Wag31 is necessary for maintaining cell shape and directing cellular growth and elongation. Wag31 has a characteristic N-terminal DivIVA-domain and a C-terminal coiled-coil domain. While the role of Wag31 in polar elongation is known, there is limited mechanistic insight on how it orchestrates growth and elongation. In this report, we delineate roles of the N-and C-terminal domains of Wag31 using genetics, state-of-the-art multi-omics, biochemical, and imaging approaches. We show that Wag31 predominantly interacts with several membrane-associated proteins involved in lipid metabolism, cell wall synthesis and division. Native levels of Wag31 are critical for the maintenance and distribution of membrane lipids. Both depletion and overexpression of Wag31 perturbs lipid homeostasis, leading to the formation of intracellular lipid inclusions (ILIs). Protein-lipid crosslinking and imaging studies reveal that purified Wag31 can bind and effectively tether Cardiolipin (CL)-containing liposomes. Despite retaining its ability to interact with partner proteins, the DivIVA domain-deleted Wag31 mutant shows defects in liposome tethering
in vitro
and non-polar localization of CL
in vivo
, which eventually causes lethality. Our study suggests that membrane tethering ‘licenses’ Wag31 to form scaffolds that help orchestrate protein-lipid and protein-protein interactions necessary for mycobacterial growth and survival.