bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinants of the Recurrences of Patients with Mental Disorders in the Psychiatric Polyclinic of Santo Vincentius Hospital, Singkawang
Authors: Sejong Maria Mardalena
Published: July 2021

Introduction: Mental disorders are very dangerous for someone even though they do not directly cause death, if not handled properly, will cause intense suffering for the individual and family. The biggest problem faced by patients with mental disorders and their families is recurrence caused by non-compliance with medication, family and environmental factors.
Objectives: The research objective was to determine the effect of social support, socioeconomic, knowledge, family support, and medication adherence on relapse in mental patients.
Methods: The research method used quantitative descriptive with cross-sectional design. The study population was all patients with mental disorders who visited the Psychiatric Polyclinic of Santo Vincentius Hospital in January 2019, totaling 600 people. The research sample consisted of 110 patients with mental disorders who were taken using the purposive sampling technique. The research instrument used a questionnaire, the results of which were analyzed using multivariate data.
Results: The results showed that social support (p-value 0.031, odds ratio 3.253), socioeconomic (p-value 0.012, odds ratio 3.557), knowledge (p-value 0.033, odds ratio 2.966), family support (p-value 0.015, odds ratio 7,845), and medication adherence (p-value 0.041, odds ratio 3.045) affected the recurrence of mental disorders patients at the Psychiatry Polyclinic of Santo Vincentius Hospital 2020.
Conclusion: The variable that had the greatest influence on the recurrence of mental disorders was family support. It is hoped that the family always strives to increase their support for patients by motivating patients, especially in taking medication, trying to meet the needs of patients in their treatment, and improving communication with patients.
EDUCATIONAL EFFECTIVENESS OF THE 5E MODEL FOR SCIENTIFIC ACHIEVEMENT OF STUDENTS WITH HEARING IMPAIRMENT
Authors: Parveen Zahida
Published: July 2021

This experimental research aimed to find the effectiveness of the 5E model of education for achievement in science among students with hearing impairment at the elementary level. An instructional package was developed following the 5E model for one unit from a science subject in grade VIII. A science test was developed by the researcher to test the achievement of students of grade VIII with hearing impairment. This test was validated by experts, pilot tested, subjected to item analysis and the reliability of the test was calculated. The test with 38 items was used as a pre-test and post-test during the study. Thirty-four students of grade VIII were selected from a school and were random assigned to two groups. One group was randomly assigned as the experimental group and the other served as the control group. The research followed a pre-test-post-test control group design. The performance of both groups was compared to evaluate the effectiveness of instructions based on the 5E model. A significant improvement was found in the performance of the experimental group as compared to the control group. It was concluded that hearing impaired children can perform better in science if they are taught through approaches promoting construction of knowledge, such as in the 5E model.
Keywords: hearing impairment, scientific achievement, 5E model.
THE APPLICATION OF CONCEPT MAPS IN THE TEACHING OF POLLINATION AND POLLINATORS IN ELEMENTARY SCHOOL
Authors: Stanisavljević Jelena D. , Bunijevac Mirka М. , Stanisavljević Ljubiša Ž.
Published: July 2021

Teaching biology is characterized by a great number of concepts and facts. It is very difficult to concisely represent all important concepts and facts. In order to effectively present important concepts such as pollination and pollinators, concept maps have been applied. In particular, the pedagogical experiment was applied to determine whether the concept maps are effective as teaching technology compared to the usual teaching approach without this technology. The research involved 110 elementary school students who were divided into one experimental (E) and one control (C) group. The E group covered programme content related to pollination and pollinators by applying concept maps. The C group was exposed to the same content, without these maps. It is evidenced a difference of the attained knowledge in favour of the experimental group after the introduction of the experimental factor (application of concept maps). The application of concept maps directly contributed to better learning and knowledge acquisition in teaching the biology content Pollination and Pollinators. Based upon the obtained results of this research, concept maps will be further implemented to improve teaching process and the teachers will be gradually trained for the application of this teaching technology.
Keywords: concept maps, programme content, pollination, pollinators.
EFFECT OF PROBLEM-BASED LEARNING ON IMPROVEMENT PHYSICS ACHIEVEMENT AND CRITICAL THINKING OF SENIOR HIGH SCHOOL STUDENT
Authors: Mundilarto Mundilarto , Ismoyo Helmiyanto
Published: July 2021

The aim of the research was to know the effect of implementation of problem-based learning model on students' physics achievement and critical thinking. The research was a quasi-experimental using a pre-test-post-test control group design. It was conducted at a state senior high school in Indonesia. The data were collected by a students' physics achievement test, a students' critical thinking test, and an observation sheet. The data were analysed by calculating normalized gain scores and hypothesis testing by using MANOVA with the significance level of .05 as criterion. The research results indicated that the average gain scores for students' physics achievement of the experimental and control groups were respectively .63 and .32, the average gain scores for students' critical thinking of the experimental and control groups were respectively .49 and .34, and a value of p is .0001 was obtained from the MANOVA calculation so that it is concluded that such learning as that in the experimental group is better in comparison with such learning as that in the control group. The results of this research are expected to increase insight and knowledge of teachers in implementing the learning process in the classroom so as to apply varied learning models. Keywords: critical thinking, physics achievement, problem-based learning.
Analysis of changes in hematological indexes and essential trace elements metabolism under the using of vitamin-amino acid complex
Authors: Vovkotrub N. , Melnyk A. , Bogatko L. , Piddubnyak O. , Sokolenko S.
Published: July 2021

It has been established that the level of blood parameters in the body of sheep is not always stable and often depends on the breed, sex, their physiological state, the level of productivity, feeding and housing conditions. Among the factors that determine the optimal sheep nutritional level, not the last place is occupied by their provision with a sufficient amount of essential amino acids, especially lysine, methionine, cystine, and vitamins, given their physiological importance for the animal body. The overwhelming amount of them is able to be synthesized in the sheep rumen with the help of microorganisms of the gastrointestinal tract, however, some of them are irreplaceable, that is, those whose balance must be replenished through feed rations. The article describes the use of the vitamin-amino acid complex "Аlphabet for Animals" in sheep, containing a complex of fat-and water-soluble vitamins, as well as amino acids, which contribute to the normalization of metabolism in the body of small ruminants, increase its resistance, have a positive effect on productivity, safety and reproductive animals functions. During the research, the effect of this feed additive on hemocytopoiesis and the exchange of essential micronutrients in ewes were studied. After a double use of the additive, an increase in the processes of erythrocytopoiesis was established, as evidenced by an increase in the number of blood erythrocytes by 21.2% and the hemoglobin content by 11.2%, stabilization of the size and degree of saturation of erythrocytes with hemoglobin, as evidenced by a decrease in MCH and MCV indices. There were no significant changes in the content of essential micronutrients in the blood serum of sheep under the influence of the "Alphabet for Animals", and a slight increase of zinc content in the blood was noted in sheep after the second injection of the drug. At the same time, in the blood of experimental animals group a significant increase the iron content on average up to 129.5±7.33 μg/100 ml (p<0.05) was established, and the number of animals with a low amount of blood iron was only 12.5 %. The number of leukocytes in the sheep blood of both groups was within the normal range and during the second and third blood tests did not change significantly. Key words: sheep, feeding, feed additives, amino acids, vitamins, hemocytopoiesis, essential micronutrients.
PROBLEMS OF LEGAL REGULATION OF TRAINING OF SCIENTIFIC AND SCIENTIFIC-PEDAGOGICAL PERSONNEL IN POSTGRADUATE STUDIES
Authors: Gabov А.V. , Sherstobitov A.E.
Published: July 2021

Introduction: this article discusses the problems of the institute of postgraduate studies (adjunct studies). The discussion on these issues has been dividing the entire scientific expert community into two camps for quite some time. The experts who make up the first of these camps believe that postgraduate studies (adjunct studies) are one of the levels of higher education. The experts who make up the second camp insist that the main task of postgraduate studies (adjunct studies) is to train a scientific researcher, not a teacher; accordingly, graduate students (adjuncts) should not attend courses of lectures and pass exams, but engage in scientific work. The relevance of the issue is explained by the discussion of a number of legislative initiatives aimed at changing the legal regulation of postgraduate studies (adjunct studies). Purpose: to show ways to solve the problems of the institute of postgraduate studies (adjunct studies), including by evaluating the draft changes in regulations. Methods: system analysis, historical method. Results: analyzed documents of a political and legal nature, as well as draft regulations aimed at reforming the institute of postgraduate studies (adjunct studies), formulated directions for its improvement. Conclusions: according to the authors, the institute of postgraduate studies (adjunct studies) is not compatible with the system of higher education because of the difference in goals that are achieved in the educational process and in the preparation of scientific research in postgraduate studies (adjunct studies), so that there is no and can be no other way than complete and decisive withdrawal of the institute of postgraduate studies (adjunct studies) from absolutely alien to him sphere of higher education in the sphere of science; only in this case, you can count on the revival of this truly important form of training scientific and pedagogical personnel of the highest category.
EVOLUTION OF CIVIL LAW RESEARCH: LINKING WITH NEW TECHNOLOGICAL REALITY
Authors: Serova O.A.
Published: July 2021

Introduction: digitalization has generated qualitative changes in many spheres of public life. The science of civil law cannot stay out of these changes. It is necessary to define new directions of scientific research, including in related fields of knowledge. Cross-sectoral research methods will take a key place in the study of the impact of digital technologies on public relations. Purpose of the research: identification of new thematic (subject) areas for the science of civil law. The relevance of these areas is determined by the high degree of penetration of digital technologies into economic and social processes. Methods: general scientific (dialectical) method, as well as such particular scientific methods of cognition, formal legal, comparative legal, logical. Discussion: a change in the subject areas of research under the influence of a new technological reality occurs in all sciences and fields of activity. Artificial intelligence technologies and robotic technology are being actively studied not only at the level of engineering sciences, mechatronics, etc., but also become an object of study in philosophy, ethics, medicine, linguistics and philology. Outside of this scientific context, research in the field of civil law is impossible. Representatives of other scientific areas determine social risks, threats and opportunities, which later take on specific outlines in the form of legal regulation models. Conclusions: the inclusion of the science of civil law in the subject areas of the new technological reality is dictated by the high social risks of technologization of law. For a long time, civil law managed to maintain a balance between the needs of civil circulation and the protection of the natural rights of citizens. Today, it is also necessary to maintain a balance between the development of digital technologies, reducing regulatory barriers and protecting the rights of citizens, as the least protected category of participants in the digitalization process.
GOAL SETTING AND ITS ACHIEVEMENT AS A CRITERION OF SCIENTIFIC RESEARCH IN THE FIELD OF CIVIL LAW
Authors: Shchennikova L.V.
Published: July 2021

Introduction: the article deals with the methodological problem of the meaning of the goal of civil law research. The author analyzes the dissertation abstracts from the point of view of goal setting, which were completed in different periods of the development of Russian civil law science, identifies the qualitative characteristics of the stages, and proves the connection of the achieved results with the researcher’s knowledge of the methodological methods of goal setting. Purpose: to show the value of goal setting in scientific research in general and in civil research in particular; to consider the relationship of goal setting with the achievement of specific scientific results on the examples of dissertations defended in the specialty 12.00.03; to justify the need to set as goals the fundamental problems associated with the identification of patterns of development of relations that are part of the subject of civil law regulation and the creation of effective mechanisms that mediate them. Methods: system-structural, system-functional, generalization, abstraction, analogy, logical, statistical, classification, legal modeling, comparative legal, forecasting, formal legal, historical. Results: civil methodology should take into account the importance of the goal in the organization of scientific work. Only a competent possession of goal setting skills can ultimately ensure the creation of scientifically-based mechanisms for effective impact of civil law norms on regulated social relations. Conclusions: 1) any science, including the science of civil law, is not only designed to study and describe existing problems, including legislative, doctrinal, and law enforcement. Research, in order to meet the criterion of scientific character, must attempt to identify the laws of development, both regulated relations and mechanisms that mediate them; 2) the significance of the goal in the development of science has been proven by outstanding philosophers. In addition, the very definition of science indicates that goal setting is one of its essential characteristics; 3) the analysis of the author’s abstracts of leading Russian tsivilists showed how the skilful setting of research goals helped to achieve them consistently, as well as to create a high-quality categorical apparatus of civil law science; 4) the analysis of modern dissertations showed that not all young researchers see the value of goal-setting and this methodological disadvantage is important for the author to eliminate.
Feasibility of Intraoperative Parathyroid Hormone Monitoring in Minimally Invasive Surgery
Authors: Kim Soo Jin , Yun Ju Hyun , Park Sohl , Go Yu Jin , Lee So Jeong , Jung Soo Yeon , Kim Han Su
Published: July 2021

Background and Objectives There has been a long debate on whether intraoperative parathyroid hormone (IOPTH) monitoring is mandatory or not in the excision of a single abnormal parathyroid gland. The aim of this study is to suggest a new criteron of IOPTH monitoring. Subjects and Method We retrospectively analyzed 31 patients who underwent parathyroidectomy from 2005 to 2019. Patients had IOPTH not measured and those with secondary hyperparathyroidism were excluded. IOPTH was measured preoperatively (EX00), at 10 minutes (EX10) and 20 minutes (EX20) after the excision and analyzed. We determined the surgery as a ‘successful excision of lesion (SEOUL)’ when it met the following criteria: criterion 1) the level of EX10 or EX20 decreased under the upper normal or under upper limit of parathyroid hormone (65 pg/mL); criterion 2) EX20 decreased below 50% of EX00 and less than 195 pg/ mL (3 times the upper normal limit); criterion 3) multiglandular disease. Results Twenty-five patients among 31 patients were included this study (M:F=8:17). Twenty- two patients were suspected of single lesion and three patients of multiple lesions on preoperative images (99mTc-sestamibi scan, neck CT, and PET-CT). IOPTH of EX00, EX10, and EX20 were 488.92±658.74, 121.36±134.73, and 92.44±111.55 pg/mL, respectively. Sixty-four percent patients (16/25) met the criterion 1. Six patients (24%) successfully excised a lesion meeting the criterion 2. Three patients had multiglandular disease, meeting the criterion 3. Conclusion Our new criteria suggest when we could stop the procedure. If the level of IOPTH does not meet the SEOUL criteria, it means that there might be more lesions.
Transcanal Endoscopic Ear Surgery with Piezoelectric Device for External Auditory Canal Lesions
Authors: Lee Chan Young , Kim Seung Ho , Choi Jeong Hwan
Published: July 2021

External auditory canal exostosis (EACE) is prone to occur in patients frequently exposed to cold water, which causes earwax impaction, recurrent otitis externa, and conductive hearing loss. The main treatment for symptomatic EACE is surgical excision. External auditory canal cholesteatoma (EACC) is a bone-destructive cystic mass caused by accumulation of plugs of desquamated keratin debris in the external auditory canal (EAC), which is also mainly treated with surgical removal. The main difficulties in the surgical removal of obstructive EACEs or EACCs are related to the adjacency of EAC skin, tympanic membrane, temporomandibular joint, and the blockage of the medial EAC landmarks during the operation. The piezoelectric device (PZD), which has long been used to cut bony structures in dental surgery, has clinical advantages here with regards to accurate exclusive bone cutting ability and minimal heat production. We report a series of cases that managed EAC lesions using PZD.
Manajemen Strategi Hubungan Masyarakat Dalam Meningkatkan Minat Calon Siswa Bersekolah Di Yayasan Surban MTs Pacet Mojokerto
Authors: Julianti Mika
Published: July 2021

Tujuan utama dilakukannya manajemen strategi hubungan masyarakat dalam sebuah lembaga pendidikan ialah agar sekolah tersebut terus diminati oleh peserta didik dan mengalami perkembang serta kemajuan dari tahun ketahun.  Dalam menyampaikan informasi diperlukan komunikasi yang baik agar informasi yang disampaikan dapat diterima. Dalam menyampaikan informasi humas harus memiliki manajemen strategi yang baik dan terarah agar apa yang diharapkan dapat terlaksana dengan baik. Teknik pengumpulan data dilakukan dengan observasi, wawancara dan dokumentasi. Hasil penelitian ini menunjukkan bahwa: (1) Manajemen Strategi Humas dalam Meningkatkan Minat Siswa Bersekolah di Yayasan Surban MTs Pacet meliputi perencanaan, pengkomunikasian, pelaksanaan dan pengevaluasian dengan baik dan terarah yang dilakukan oleh pihak sekolah untuk menarik perhatian calon peserta didik baru. (2) Salah satu faktor penghambat humas dalam meningkatkan minat calon siswa bersekolah di Yayasan Surban MTs Pacet meliputi waktu yang kurang efektif dalam pelaksanaan manajemen serta jarak lokasi yang jauh sehingga manajemen strategi yang dilakukan kurang maksimal.
Quiste de erupción dental. Reporte de caso
Authors: Rocafuerte-Acurio Marco Antonio , Velásquez-Vásquez Fiorella Roxanna
Published: July 2021

Eruption cysts are benign lesions of soft tissue that appear on the mucosa of a tooth shortly before its eruption. These may go away on their own, but if they hurt, bleed, or become infected, they may require surgical treatment to expose the tooth and drain its content. We will present a case of an eruption cyst at the level of pieces 5.5 and 6.5 whose treatment was surgical in order to expose the crowns of the teeth. The objective of this article is to present the most relevant aspects related to this developmental alteration in order to achieve a correct diagnosis and provide an adequate treatment.
Consideraciones para la elección de técnicas de manejo del comportamiento en niños durante la pandemia por la COVID-19
Authors: Fracchia González Piero , Yupanqui Cayampi Viviana , Sihuay Torres Kamila
Published: July 2021

La actual pandemia provocada por el coronavirus COVID-19, ha provocado innumerables restricciones y pérdidas en el sector sanitario, teniendo que someternos a cuarentenas obligatorias que en muchos casos afectan directamente a la atención odontológica. Esta inusual situación afecta gravemente a la ya frágil relación paciente-operador; teniendo en cuenta que el paciente es un niño, la situación se complica un poco más.
Human Response to Longitudinal Perturbations of Standing Passengers on Public Transport During Regular Operation
Authors: Krašna Simon , Keller Arne , Linder Astrid , Silvano Ary P. , Xu Jia-Cheng , Thomson Robert , Klug Corina
Published: July 2021

This study investigates the response of standing passengers on public transport who experience balance perturbations during non-collision incidents. The objective of the study was to analyse the effects of the perturbation characteristics on the initial responses of the passengers and their ability to maintain their balance. Sled tests were conducted on healthy volunteers aged 33.8 ± 9.2 years (13 males, 11 females) standing on a moving platform, facilitating measurements of the initial muscle activity and stepping response of the volunteers. The volunteers were exposed to five different perturbation profiles representing typical braking and accelerating manoeuvres of a public transport bus in the forward and backward direction. The sequence of muscle activations in lower-extremity muscles was consistent for the perturbation pulses applied. For the three acceleration pulses combining two magnitudes for acceleration (1.5 and 3.0 m/s2) and jerk (5.6 and 11.3 m/s3), the shortest muscle onset and stepping times for the passengers to recover their balance were observed with the higher jerk value, while the profile with the higher acceleration magnitude and longer duration induced more recovery steps and a higher rate of safety-harness deployment. The tendency for a shorter response time was observed for the female volunteers. For the two braking pulses (1.0 and 2.5 m/s2), only the lower magnitude pulse allowed balance recovery without compensatory stepping. The results obtained provide a reference dataset for human body modelling, the development of virtual test protocols, and operational limits for improving the safety of public transportation vehicles and users.
Comparison of the Mechanical Properties Between the Convex and Concave Inner/Apical Surfaces of the Developing Cerebrum
Authors: Nagasaka Arata , Miyata Takaki
Published: July 2021

The inner/apical surface of the embryonic brain wall is important as a major site for cell production by neural progenitor cells (NPCs). We compared the mechanical properties of the apical surfaces of two neighboring but morphologically distinct cerebral wall regions in mice from embryonic day (E) E12–E14. Through indentation measurement using atomic force microscopy (AFM), we first found that Young’s modulus was higher at a concave-shaped apical surface of the pallium than at a convex-shaped apical surface of the ganglionic eminence (GE). Further AFM analysis suggested that contribution of actomyosin as revealed with apical surface softening by blebbistatin and stiffness of dissociated NPCs were both comparable between pallium and GE, not accounting for the differential apical surface stiffness. We then found that the density of apices of NPCs was greater, with denser F-actin meshwork, in the apically stiffer pallium than in GE. A similar correlation was found between the decreasing density between E12 and E14 of NPC apices and the declining apical surface stiffness in the same period in both the pallium and the GE. Thus, one plausible explanation for the observed difference (pallium > GE) in apical surface stiffness may be differential densification of NPC apices. In laser ablation onto the apical surface, the convex-shaped GE apical surface showed quicker recoils of edges than the pallial apical surface did, with a milder inhibition of recoiling by blebbistatin than in pallium. This greater pre-stress in GE may provide an indication of how the initially apically concave wall then becomes an apically convex “eminence.”
Structural Variations of the 3D Genome Architecture in Cervical Cancer Development
Authors: Adeel Muhammad Muzammal , Jiang Hao , Arega Yibeltal , Cao Kai , Lin Da , Cao Canhui , Cao Gang , Wu Peng , Li Guoliang
Published: July 2021

Human papillomavirus (HPV) integration is the major contributor to cervical cancer (CC) development by inducing structural variations (SVs) in the human genome. SVs are directly associated with the three-dimensional (3D) genome structure leading to cancer development. The detection of SVs is not a trivial task, and several genome-wide techniques have greatly helped in the identification of SVs in the cancerous genome. However, in cervical cancer, precise prediction of SVs mainly translocations and their effects on 3D-genome and gene expression still need to be explored. Here, we have used high-throughput chromosome conformation capture (Hi-C) data of cervical cancer to detect the SVs, especially the translocations, and validated it through whole-genome sequencing (WGS) data. We found that the cervical cancer 3D-genome architecture rearranges itself as compared to that in the normal tissue, and 24% of the total genome switches their A/B compartments. Moreover, translocation detection from Hi-C data showed the presence of high-resolution t(4;7) (q13.1; q31.32) and t(1;16) (q21.2; q22.1) translocations, which disrupted the expression of the genes located at and nearby positions. Enrichment analysis suggested that the disrupted genes were mainly involved in controlling cervical cancer-related pathways. In summary, we detect the novel SVs through Hi-C data and unfold the association among genome-reorganization, translocations, and gene expression regulation. The results help understand the underlying pathogenicity mechanism of SVs in cervical cancer development and identify the targeted therapeutics against cervical cancer.
Developmental Robustness: The Haltere Case in Drosophila
Authors: Giraud Guillaume , Paul Rachel , Duffraisse Marilyne , Khan Soumen , Shashidhara L. S. , Merabet Samir
Published: July 2021

Developmental processes have to be robust but also flexible enough to respond to genetic and environmental variations. Different mechanisms have been described to explain the apparent antagonistic nature of developmental robustness and plasticity. Here, we present a “self-sufficient” molecular model to explain the development of a particular flight organ that is under the control of the Hox geneUltrabithorax(Ubx) in the fruit flyDrosophila melanogaster. Our model is based on a candidate RNAi screen and additional genetic analyses that all converge to an autonomous and cofactor-independent mode of action for Ubx. We postulate that this self-sufficient molecular mechanism is possible due to an unusually high expression level of the Hox protein. We propose that high dosage could constitute a so far poorly investigated molecular strategy for allowing Hox proteins to both innovate and stabilize new forms during evolution.
Effects of Smoking on Inflammatory Markers in a Healthy Population as Analyzed via the Gut Microbiota
Authors: Yan Su , Ma Zhonghui , Jiao Mengfan , Wang Youxiang , Li Ang , Ding Suying
Published: July 2021

The number of people who smoke has increased in recent years, and the incidence of smoking-related diseases increases annually. This study was conducted to explore whether smoking affects diseases via changes in the gut microbiota. We enrolled 33 smokers and 121 non-smokers. We collected fecal samples from all participants and performed whole-genome sequencing. Smoking significantly affected the gut microbiota. At the phylum through genus levels, the smokers’ microbiotas showed slight changes compared with those of the non-smokers. The α- and β-diversities differed significantly between the smokers and non-smokers, and the smokers’ gut microbiota compositions differed significantly from those of the non-smokers. At the species level, the relative abundances of Ruminococcus gnavus (P=0.00197) and Bacteroides vulgatus (P=0.0468) were significantly greater in the smokers than in the non-smokers, while the relative abundances of Faecalibacterium prausnitzii (P=0.0000052) and Akkermansia muciniphila (P=0.0057) were significantly lower in the smokers. Smoking increases inflammation in the body by inducing an increased abundance of proinflammatory bacteria. Non-smokers had higher abundances of anti-inflammatory microorganisms than did smokers; these microorganisms can produce short-chain fatty acids, which inhibit inflammation.
Sinus Microbiota in Patients With Eosinophilic and Non-Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Authors: Feng Tingting , Miao Ping , Liu Bin , Liu Yao , Bao Ximing , Xu Ji , Ren Nana , Li Ying , Shi Jiali , Cao Wanxin , Fang Jianchen , Li Min , Liu Qian , Li Jiping
Published: July 2021

Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by Th2-skewed inflammation and increased colonization by Staphylococcus aureus. CRSwNP can be distinguished as eosinophilic (ECRSwNP) and non-eosinophilic (NECRSwNP) by the infiltration of eosinophils. The local microbiota plays an important role in the persistent inflammation of CRSwNP. To evaluate the bacterial community composition on the distinct types of CRSwNP patients, we collected nasal swabs from 16 ECRSwNP patients, 18 NECRSwNP patients, and 39 healthy control subjects. The microbiome structure for all the samples were analyzed by high-throughput 16S rRNA gene sequencing. Concentration of S. aureus was determined using TaqMan quantitative polymerase chain reaction (qPCR) targeting the nuclease (nuc) gene. The result showed significant differences in the sinus microbiome among healthy control subjects and CRSwNP patients. Microbiota community diversity was significantly lower in NECRSwNP samples compared to that of healthy control subjects. Interestingly, the abundance of several pathogenic bacteria was diverse between ECRSwNP and NECRSwNP patients. Although Staphylococcus prevailed in all groups, the abundance of Staphylococcus was significantly higher in the healthy control group than the ECRSwNP group. More importantly, the abundance of S. aureus was much higher in NECRSwNP patients. This study highlights that microbiota composition may contribute to the different clinical types of CRSwNP, inspiring new therapeutic strategies to resolve this chronic inflammation process.
The Dichloromethane Fraction of Croton sonorae, A Plant Used in Sonoran Traditional Medicine, Affect Entamoeba histolytica Erythrophagocytosis and Gene Expression
Authors: Villegas-Gómez Isaac , Silva-Olivares Angélica , Robles-Zepeda Ramón Enrique , Gálvez-Ruiz Juan-Carlos , Shibayama Mineko , Valenzuela Olivia
Published: July 2021

Intestinal parasites are a global problem, mainly in developing countries. Obtaining information about plants and compounds that can combat gastrointestinal disorders and gastrointestinal symptoms is a fundamental first step in designing new treatment strategies. In this study, we analyzed the antiamoebic activity of the aerial part of Croton sonorae. The dichloromethane fraction of C. sonorae (CsDCMfx) contained flavonoids, terpenes, alkaloids, and glycosides. The ultrastructural morphology of the amoebae treated for 72 h with CsDCMfx was completely abnormal. CsDCMfx reduced erythrophagocytosis of trophozoites and the expression of genes involved in erythrocyte adhesion (gal/galnac lectin) and actin cytoskeleton rearrangement in the phagocytosis pathway (rho1 gtpase and formin1). Interestingly, CsDCMfx decreased the expression of genes involved in Entamoeba histolytica trophozoite pathogenesis, such as cysteine proteases (cp1, cp4, and cp5), sod, pfor, and enolase. These results showed that C. sonorae is a potential source of antiamoebic compounds.
Impact of Age on Outcomes in Patients With Cardiogenic Shock
Authors: Kanwar Manreet , Thayer Katherine L. , Garan Arthur Reshad , Hernandez-Montfort Jaime , Whitehead Evan , Mahr Claudius , Sinha Shashank S. , Vorovich Esther , Harwani Neil M. , Zweck Elric , Abraham Jacob , Burkhoff Daniel , Kapur Navin K.
Published: July 2021

Background: Advanced age is associated with poor outcomes in cardiovascular emergencies. We sought to determine the association of age, use of support devices and shock severity on mortality in cardiogenic shock (CS).

Methods: Characteristics and outcomes in CS patients included in the Cardiogenic Shock Work Group (CSWG) registry from 8 US sites between 2016 and 2019 were retrospectively reviewed. Patients were subdivided by age into quintiles and Society for Cardiovascular Angiography & Interventions (SCAI) shock severity.

Results: We reviewed 1,412 CS patients with a mean age of 59.9 ± 14.8 years, including 273 patients > 73 years of age. Older patients had significantly higher comorbidity burden including diabetes, hypertension and coronary artery disease. Veno-arterial extracorporeal membrane oxygenation was used in 332 (23%) patients, Impella in 410 (29%) and intra-aortic balloon pump in 770 (54%) patients. Overall in-hospital survival was 69%, which incrementally decreased with advancing age (p < 0.001). Higher age was associated with higher mortality across all SCAI stages (p = 0.003 for SCAI stage C; p < 0.001 for SCAI stage D; p = 0.005 for SCAI stage E), regardless of etiology (p < 0.001).

Conclusion: Increasing age is associated with higher in-hospital mortality in CS across all stages of shock severity. Hence, in addition to other comorbidities, increasing age should be prioritized during patient selection for device support in CS.
Triglyceride–Glucose Index Independently Predicts New-Onset Atrial Fibrillation After Septal Myectomy for Hypertrophic Obstructive Cardiomyopathy Beyond the Traditional Risk Factors
Authors: Wei Zhipeng , Zhu Enjun , Ren Changwei , Dai Jiang , Li Jinhua , Lai Yongqiang
Published: July 2021

The triglyceride–glucose index is a valuable marker of insulin resistance. However, the predictive value of this index for postoperative atrial fibrillation in patients undergoing septal myectomy remains unclear. A total of 409 patients with hypertrophic obstructive cardiomyopathy who underwent septal myectomy were recruited in this study. The triglyceride–glucose index was calculated for all patients preoperatively. All patients underwent clinical data collection, blood sampling, and standard echocardiographic examinations during hospitalization. The prevalence of postoperative atrial fibrillation was approximately 15% in the present study. Multivariate logistic regression revealed that age (odds ratio [OR]: 1.053, 95% CI: 1.016–1.090, P = 0.004), hypertension (OR: 2.399, 95% CI: 1.228–4.686, P = 0.010), left atrial diameter (OR: 1.101, 95% CI: 1.050–1.155, P < 0.001), and triglyceride–glucose index (OR: 4.218, 95% CI: 2.381–7.473, P < 0.001) were independent risk factors for postoperative atrial fibrillation in patients undergoing septal myectomy. In receiver operating characteristic curve analysis, the triglyceride–glucose index could provide a moderate predictive value for postoperative atrial fibrillation after septal myectomy 0.723 (95% CI: 0.650–0.796, P < 0.001). Moreover, adding the triglyceride–glucose index to conventional risk factor model could numerically but not significantly increase our ability to predict postoperative atrial fibrillation (area under the receiver: 0.742 (0.671–0.814) vs. 0.793 (0.726–0.860), p = 0.065) after septal myectomy. In our retrospective cohort study, the triglyceride–glucose index was identified as an independent predictor of postoperative atrial fibrillation in patients undergoing septal myectomy.
Comparing Greenland Ice Sheet Melt Variability From Different Satellite Passive Microwave Remote Sensing Products Over a Common 5-year Record
Authors: Kimball John S. , Du Jinyang , Meierbachtol Toby W. , Kim Youngwook , Johnson Jesse V.
Published: July 2021

Satellite microwave brightness temperature (Tb) observations over the Greenland Ice Sheet permit determination of melted/frozen snow conditions at spatial and temporal scales that are uniquely suited for climate model validation and metrics of ice sheet change. Strong microwave sensitivity to the presence of liquid water in the snowpack is clear. Yet, a host of unique microwave-derived melt products covering the ice sheet are available, each based on different methodology, and with unknown inter-product agreement. Here, we compared five different published microwave melt products over a common 5-year (2003–2007) record to establish compatibility between products and agreement with in situ observations from a network of on-ice weather stations (AWS) spanning the ice sheet. A sixth product, leveraging both Tb seasonal trends and diurnal variability, was also introduced and included in the comparison. We found variable agreement between products and observations, with melt estimates based on microwave emissions modeling and the newly presented Adaptive Threshold (ADT) algorithm showing the best performance for AWS sites with more than 1-day average annual melt period (e.g., 68.9% of ADT melt days consistent with AWS observations; 31.1% of ADT frozen days contrasting with AWS observed melt). Spatial patterns of melting also varied between products. The different products showed substantial spread in melt occurrence even for products with the best AWS agreement. Product differences were generally larger under higher melt conditions; whereby, the fraction of the ice sheet experiencing ≥25 days of melting each year ranged from 4 to 25% for different products. While long-term satellite records have consistently shown increasing decadal trends in melt extent, our results imply that the melt frequency at any given location, particularly in the ice sheet interior where melting is less prevalent, is still subject to significant uncertainty.
LSAMP-NICE: Expanding International STEM Research for Underrepresented Minorities
Authors: Benjamin Mary E. , Yates Denise , Dupuis Steve
Published: July 2021

Background: The global challenges of climate change, disease and hunger exceed national borders as do possibilities of sustained life, exploration and economic development in outer space. Both help to underscore the need for sustained international STEM research to leverage the talent embedded in different countries and in diverse groups within countries. This study focuses on the United States National Science Foundation provision of funds to its Louis Stokes Alliance for Minority Participation (LSAMP) Program to create a National Center of Excellence LSAMP-NICE for the establishment of international STEM Research Partnerships with a particular emphasis on the integration of international collaborative research for underrepresented minority STEM faculty, students and graduates. The study focuses on the diffusion of this Center’s services to the LSAMP Community, a group of 56 LSAMP funded STEM enrichment programs located across the United States. We found that LSAMP-NICE used mass media (a website and two advertorials in a national journal) and an annual national meeting as its major diffusion strategies during its first two years. Forty-two (42) programs responded to the questionnaire. The majority of the respondents (71.4%) had not used the website; 88.1% had not read the Advertorial in Science Magazine; and 78.6% did not attend the national 2019 LSAMP-NICE Annual Meeting in Washington, D.C. Our study suggests a need for additional diffusion techniques to reach the intended audience. Some respondent suggestions for diffusion include participation by LSAMP-NICE representatives at LSAMP Regional Conferences and Symposia, visits by LSAMP-NICE staff to LSAMP programs, forging relationships with higher education institutions abroad so LSAMP students can obtain summer or longer-term research experiences and providing technical assistance on applying for international travel funds.
The Molecular Mechanism of Sex Hormones on Sertoli Cell Development and Proliferation
Authors: Shah Wasim , Khan Ranjha , Shah Basit , Khan Asad , Dil Sobia , Liu Wei , Wen Jie , Jiang Xiaohua
Published: July 2021

Sustaining and maintaining the intricate process of spermatogenesis is liable upon hormones and growth factors acting through endocrine and paracrine pathways. The Sertoli cells (SCs) are the major somatic cells present in the seminiferous tubules and are considered to be the main regulators of spermatogenesis. As each Sertoli cell supports a specific number of germ cells, thus, the final number of Sertoli cells determines the sperm production capacity. Similarly, sex hormones are also major regulators of spermatogenesis and they can determine the proliferation of Sertoli cells. In the present review, we have critically and comprehensively discussed the role of sex hormones and some other factors that are involved in Sertoli cell proliferation, differentiation and maturation. Furthermore, we have also presented a model of Sertoli cell development based upon the recent advancement in the field of reproduction. Hence, our review article provides a general overview regarding the sex hormonal pathways governing Sertoli cell proliferation and development.
PSO Supported Ensemble Algorithm for Bad Data Detection Against Intelligent Hacking Algorithm
Authors: Yavuz Levent , Soran Ahmet , Onen Ahmet , Muyeen SM
Published: July 2021

Power system cybersecurity has recently become important due to cyber-attacks. Due to advanced computer science and machine learning (ML) applications being used by malicious attackers, cybersecurity is becoming crucial to creating sustainable, reliable, efficient, and well-protected cyber-systems. Power system operators are needed to develop sophisticated detection mechanisms. In this study, a novel machine-learning-based detection algorithm that combines the five most popular ML algorithms with Particle Swarm Optimizer (PSO) is developed and tested by using an intelligent hacking algorithm that is specially developed to measure the effectiveness of this study. The hacking algorithm provides three different types of injections: random, continuous random, and slow injections by adaptive manner. This would make detection harder. Results shows that recall values with the proposed algorithm for each different type of attack have been increased.
Life Cycle Assessment of Green Diesel Production by Hydrodeoxygenation of Palm Oil
Authors: Arguelles-Arguelles Antonio , Amezcua-Allieri Myriam Adela , Ramírez-Verduzco Luis Felipe
Published: July 2021

Transition to a new energy low carbon pool requires the gradual replacing of fossil fuels with other cleaner energies and biofuels. In this work, the environmental impact of renewable diesel production using an attributional life cycle assessment was evaluated by considering five stages: palm plantation-culture-harvest, palm oil extraction, palm oil refining, green (renewable) diesel production, and biofuel use. The functional unit was established as 1.6 × 10−2 m3(13.13 kg) of renewable diesel. The results show that the production of renewable diesel by Hydro-processed Esters and Fatty Acids is more environmentally friendly than fossil diesel production. In particular, the analysis showed that the CO2emission decreases around 110% (i.e. mitigation occurred) compared with conventional diesel production. However, renewable diesel production has a relevant environmental impact in the human toxicity category due to the high consumption of agrochemicals during palm culture.
Evaluation of Single-Node Performance of Parallel Algorithms for Multigroup Monte Carlo Particle Transport Methods
Authors: Ma Donghui , Yang Bo , Zhang Qingyang , Liu Jie , Li Tiejun
Published: July 2021

Monte Carlo (MC) methods have been widely used to solve the particle transport equation due to their high accuracy and capability of processing complex geometries. History-based and event-based algorithms that are applicable to different architectures are two methods for parallelizing the MC code. There is a large work on evaluating and optimizing parallel algorithms with continuous-energy schemes. In this work, we evaluate the single-node performance of history-based and event-based algorithms for multigroup MC methods on both CPUs and GPUs with Quicksilver, a multigroup MC transport code that has already implemented the history-based algorithms. We first implement and optimize the event-based algorithm based on Quicksilver and then perform the evaluation work extensively on the Coral2 benchmark. Numerical results indicate that contrary to continuous-energy schemes, the history-based approach with multigroup schemes outperforms the event-based algorithm on both architectures in all cases. We summarize that the performance loss of the event-based algorithm is mainly due to: 1) extra operations to reorganize particles, 2) batched atomic operations, and 3) poor particle data locality. Despite the poor performance, the event-based algorithm achieves higher memory bandwidth utilization. We further discuss the impact of memory access patterns and calculation of cross sections (xs) on the performance of the GPU. Built on the analytics, and shed light on the algorithm choice and optimizations for paralleling the MC transport code on different architectures.
Analysis of the Upgrading Effect of the Industrial Structure of Environmental Regulation: Evidence From 113 Cities in China
Authors: Shao Wei , Yin Yufei , Bai Xiao , Taghizadeh-Hesary Farhad
Published: July 2021

At present, China’s economy is in a crucial period of economic structural transformation. To alleviate the downward pressure on the economy and explore sustainable growth paths, the Chinese government has issued several environmental regulations. However, the impact of environmental regulation on industrial structure upgrading has not been carefully examined yet. This study utilizes the Pollution Information Transparency Index (PITI) to measure environmental regulation (ER) and examines the impact of ER on industrial structure upgrading (ISU). The sample cities are divided into 36 resource-based cities (RBCs) and 77 non–resource-based cities (NRBCs). The panel data containing 113 cities during 2008–2017 are used in this study. The empirical results show that ER has a significant impact on ISU of RBCs and NRBCs, and robust tests proved the reliability of this result. Analysis of heterogeneity shows ER has a more substantial role in promoting ISU in RBCs and the eastern region. Meanwhile, inside RBCs, ER has a more substantial impact on ISU in growth-RBCs than on that in other RBCs. The mechanism test shows that the mediation effect of technological innovation in RBCs and NRBCs is significant. At last, the impact of ER on ISU has a double-threshold effect in RBCs and a single-threshold effect in NRBCs. With the technological innovation progress, ER produces an increasing effect on ISU of RBCs and NRBCs.