bluuebunny/crossref_metadata_2025 huggingface dataset:
A Family of Semitoric Systems with Four Focus–Focus Singularities and Two Double Pinched Tori
Authors: De Meulenaere Annelies , Hohloch Sonja
Published: May 2021

We construct a one-parameter family $$F_t=(J, H_t)_{0 \le t \le 1}$$

F
t

=

(
J
,

H
t

)

0
≤
t
≤
1

of integrable systems on a compact 4-dimensional symplectic manifold $$(M, \omega )$$

(
M
,
ω
)

that changes smoothly from a toric system $$F_0$$

F
0

with eight elliptic–elliptic singular points via toric type systems to a semitoric system $$F_t$$

F
t

for $$ t^-< t < t^+$$

t
-

<
t
<

t
+

. These semitoric systems $$F_t$$

F
t

have precisely four elliptic–elliptic and four focus–focus singular points. Moreover, at $$t= \frac{1}{2}$$

t
=

1
2

, the system has precisely two focus–focus fibres each of which contains exactly two focus–focus points, giving these fibres the shape of double pinched tori. We exemplarily parametrise one of these fibres explicitly.
Variation of the cochlear anatomy and cochlea duct length: analysis with a new tablet-based software
Authors: Spiegel Jennifer L. , Polterauer Daniel , Hempel John-Martin , Canis Martin , Spiro Judith E. , Müller Joachim
Published: May 2021

Purpose

In cochlear implantation, thorough preoperative planning together with measurement of the cochlear duct length (CDL) assists in choosing the correct electrode length. For measuring the CDL, different techniques have been introduced in the past century along with the then available technology. A tablet-based software offers an easy and intuitive way to visualize and analyze the anatomy of the temporal bone, its proportions and measure the CDL. Therefore, we investigated the calculation technique of the CDL via a tablet-based software on our own cohort retrospectively.

Methods

One hundred and eight preoperative computed tomography scans of the temporal bone (slice thickness < 0.7 mm) of already implanted FLEX28™ and FLEXSOFT™ patients were found eligible for analysis with the OTOPLAN software. Measurements were performed by two trained investigators independently. CDL, angular insertion depth (AID), and cochlear coverage were calculated and compared between groups of electrode types, sex, sides, and age.

Results

Mean CDL was 36.2 ± 1.8 mm with significant differences between sex (female: 35.8 ± 0.3 mm; male: 36.5 ± 0.2 mm;p = 0.037), but none concerning side or age. Differences in mean AID (FLEX28: 525.4 ± 46.4°; FLEXSOFT: 615.4 ± 47.6°), and cochlear coverage (FLEX28: 63.9 ± 5.6%; FLEXSOFT: 75.8 ± 4.3%) were significant (p < 0.001).

Conclusion

A broad range of CDL was observed with significant larger values in male, but no significant differences concerning side or age. Almost every cochlea was measured longer than 31.0 mm. Preoperative assessment aids in prevention of complications (incomplete insertion, kinking, tipfoldover), attempt of atraumatic insertion, and addressing individual necessities (hearing preservation, cochlear malformation). The preferred AID of 720° (two turns of the cochlea) was never reached, opening the discussion for the requirement of longer CI-electrodes versus a debatable audiological benefit for the patient in his/her everyday life.
Impact of different work organizational models on gender differences in exposure to psychosocial and ergonomic hazards at work and in mental and physical health
Authors: Migliore Maria Cristina , Ricceri Fulvio , Lazzarato Fulvio , d’Errico Angelo
Published: May 2021

Purpose

To examine differences between genders in exposure to psychosocial and ergonomic factors at work and in work-related health, according to different work organization models.

Methods

The study population included a sample of 9749 (women: 37.1%) and 10,374 (women: 39.9%) employees who participated in the 2010 and 2015 European Working Conditions Surveys, respectively. Multiple Correspondence Analysis was applied to work characteristics reported by workers to estimate principal components, followed by Hierarchical Clustering on principal components to identify clusters of work organization models. Gender differences in exposure to work hazards and health outcomes were assessed through Poisson robust regression. Differences of PRs across organizational models were tested through interaction between gender and type of work organization.

Results

Three organizational models were identified in 2010, including lean production, Tayloristic production, and a “reflexive production” model, whereas in 2015, a “simple” or traditional model was also found. In 2010, women employed in companies adopting the Tayloristic or the lean production models were more likely than men to be exposed to unfavourable psychosocial and physical work factors, and to report musculoskeletal pain, compared to those belonging to reflexive production. In 2015, a significantly higher female/male ratio persisted in lean production for exposure to high job strain and for carrying/moving heavy loads, whereas gender differences in Tayloristic and traditional production were quite similar to those of reflexive production.

Conclusions

Our results suggest that employment in workplaces characterized by lower monotony, repetitiveness, and production constraints may contribute to reduce exposure to job strain among working women.
Angiogenesis and chemotherapy resistance: optimizing chemotherapy scheduling using mathematical modeling
Authors: Bodzioch Mariusz , Bajger Piotr , Foryś Urszula
Published: May 2021

Chemotherapy remains a widely used cancer treatment. Acquired drug resistance may greatly reduce the efficacy of treatment and means to overcome it are a topic of active discussion among researchers. One of the proposed solutions is to shift the therapeutic paradigm from complete eradication of cancer to maintenance, i.e., to treat it as a chronic disease. A concept of metronomic therapy (low chemotherapy doses applied continuously) emerged in early 2000s and was henceforth shown to offer a number of benefits, including targeting endothelial cells and reducing acquired drug resistance. Using mathematical modeling and optimal control techniques, we investigate the hypothesis that lower doses of chemotherapy are beneficial for patients. Our analysis of a mathematical model of tumor growth under angiogenic signaling proposed by Hahnfeldt et al. adapted to heterogeneous tumors treated by combined anti-angiogenic agent and chemotherapy offers insights into the effects of metronomic therapy. Firstly, assuming constant long-term drug delivery, the model suggests that the longest survival time is achieved for intermediate drug doses. Secondly, by formalizing the notion of the therapeutic target being maintenance rather than eradication, we show that in the short term, optimal chemotherapy scheduling consists mainly of a drug applied at a low dose. In conclusion, we suggest that metronomic therapy is an attractive alternative to maximum tolerated dose therapies to be investigated in experimental settings and clinical trials.
Biomass allocation and seasonal non-structural carbohydrate dynamics do not explain the success of tall forbs in short alpine grassland
Authors: Hiltbrunner Erika , Arnaiz Jonas , Körner Christian
Published: May 2021

The majority of alpine plants are of small stature. Through their small size alpine plants are decoupled from the free atmospheric circulation and accumulate solar heat. However, a few alpine species do not follow that “rule” and protrude with their aboveground structures from the microclimatic shelter of the main canopy boundary layer. We aim at explaining the phenomenon of being tall by exploring the biomass production and carbon relations of four pairs of small and tall phylogenetically related taxa in alpine grassland. We compared species and stature-specific biomass allocation, shifts in non-structural carbohydrate (NSC) concentrations in different tissues throughout the season, and we used 13C labels to track carbon transfer from leaves to belowground structures. Small and tall herbs did not differ in their above- to belowground biomass allocation. The NSC composition (starch, fructan, simple sugars) and allocation did not show a stature-specific pattern, except for higher concentrations of simple sugars in tall species during their extended shoot growth. In relative terms, tall species had higher NSC pools in rhizomes, whereas small species had higher NSC pools in roots. Our findings do not place tall alpine forbs in an exceptional category in terms of biomass allocation and carbohydrate storage. The tall versus small stature of the examined herbs does not seem to be associated with specific adjustments in carbon relations. 13C pulse labelling revealed early C autonomy in young, unfolding leaves of the tall species, which are thus independent of the carbon reserves in the massive belowground organs.
A spectral shape optimization problem with a nonlocal competing term
Authors: Mazzoleni Dario , Ruffini Berardo
Published: May 2021

We study the minimization of a spectral functional made as the sum of the first eigenvalue of the Dirichlet Laplacian and the relative strength of a Riesz-type interaction functional. We show that when the Riesz repulsion strength is below a critical value, existence of minimizers occurs. Then we prove, by means of an expansion analysis, that the ball is a rigid minimizer when the Riesz repulsion is small enough. Eventually we show that for certain regimes of the Riesz repulsion, regular minimizers do not exist.
Müller–Zhang truncation for general linear constraints with first or second order potential
Authors: Gallenmüller Dennis
Published: May 2021

Let $$\mathcal {B}$$
B
be a homogeneous differential operator of order $$l=1$$

l
=
1

or $$l=2$$

l
=
2

. We show that a sequence of functions of the form $$(\mathcal {B}u_j)_j$$

(
B

u
j

)

j

converging in the $$L^1$$

L
1

-sense to a compact, convex set K can be modified into a sequence converging uniformly to this set provided that the derivatives of order l are uniformly bounded. We prove versions of our result on the whole space, an open domain, and for K varying uniformly continuously on an open, bounded domain. This is a conditional generalization of a theorem proved by S. Müller for sequences of gradients. Moreover, a potential of order two for the linearized isentropic Euler system is constructed.
Dispersion EPR: Considerations for Low-Frequency Experiments
Authors: Hyde James S. , Strangeway Robert A. , Sidabras Jason W.
Published: May 2021

The hypothesis is made that the dispersion electron paramagnetic resonance (EPR) spectrum can yield a higher signal-to-noise ratio than the absorption spectrum in diagnostic examinations if phase noise in the bridge is under control. The rationale for this hypothesis is based on the observation that the dispersion spectrum becomes more intense than the absorption spectrum at high incident powers. The rationale is dependent on optimization of high microwave efficiency (Λ; mT/W1/2) and low-quality factor (Q-value) sample resonators as well as the use of microwave sources with reduced phase noise. Microwave frequencies from 1.2 to 94 GHz are considered. Although the dispersion display appears to be observable with an adequate signal-to-noise ratio for most EPR research initiatives, a weakness of microwave bridges for studies at high incident microwave power was identified. Spurious leakage of incident microwave power through the circulator, thereby bypassing the probe leading to the resonator, can result in a decreased signal-to-noise ratio in both absorption and dispersion because of phase noise. For dispersion EPR with low Q-value sample resonators, this leakage is the primary contributor to phase noise at the receiver. In this work, we focus on the design of microwave reflection bridges and discuss possible methods to ameliorate this source of noise.
Relation between the size of patent foramen ovale and the volume of acute cerebral ischemic lesion in young patients with cryptogenic ischemic stroke
Authors: Benvenuti Federica , Meucci Francesco , Vuolo Luisa , Nistri Rita , Pracucci Giovanni , Picchioni Antonella , Venturini Gabriele , Stolcova Miroslava , Failli Ylenia , Nencini Patrizia , Di Mario Carlo , Sarti Cristina ,   on behalf of Heart and Brain Team Careggi University Hospital, Florence, Italy
Published: May 2021

Background

Patent foramen ovale (PFO) closure is superior to medical therapy alone to prevent stroke recurrence in selected patients. Small cortical infarcts and large right to left shunts seem to identify patients who will benefit most from closure. We aimed to study the correlation between the size of the PFO and the volume of cerebral ischemic lesions in young patients with cryptogenic ischemic stroke.

Methods

PFO dimensions and acute ischemic lesion volume of 20 patients, aged<55 years, were analyzed with transesophageal echocardiography and brain magnetic resonance imaging, respectively. The association between the volume of ischemic lesions with the length of PFO, maximum separation between septum primum and septum secundum, and the combination of the twos was explored.

Results

A direct statistically significant correlation was found between cerebral lesion volume and maximum separation of septum primum and septum secundum (p=0.047). Length of PFO showed a non-significant trend towards an inverse correlation with lesion volume (p=0.603). Multiple linear regression analysis showed that cerebral lesion volume was dependent directly on maximum separation and inversely on length of PFO (regression coeff. −0,837; p= 0.057; 2,536, p=0.006, respectively).

Conclusions

These data suggest that even small PFO might be pathogenetic in case of small cerebral infarcts and that large cerebral infarcts might be PFO related if the shunt is large. If confirmed, the combination of detailed characteristics of PFO with the volume of cerebral infarct could be integrated in a new score to select patients who would take real advantage from a percutaneous closure.
Monetary risk measures for stochastic processes via Orlicz duality
Authors: Kountzakis Christos E. , Rossello Damiano
Published: May 2021

In this article, we extend the framework of monetary risk measures for stochastic processes to account for heavy tailed distributions of random cash flows evolving over a fixed trading horizon. To this end, we transfer the $$L^p$$

L
p

-duality underlying the representation of monetary risk measures to a more flexible Orlicz duality, in spaces of stochastic processes modelling random future evolution of financial values in continuous time over a finite horizon. This contributes, on the one hand, to the theory of real-valued monetary risk measures for processes and, on the other hand, supports a new representation of acceptability indices of financial performance.
Decadal changes in the rice-cropping system in the Ayeyarwady Delta using a large archive of satellite imagery from 1981 to 2020
Authors: Sakai Toru , Omori Keisuke , Oo Aung Naing , Ma Swe Swe , Zaw Yan Naung
Published: May 2021

In the last 40 years, the rice-cropping system has considerably changed in the Ayeyarwady Delta. The large archive of satellite imagery provides a history of how land and water resource managements have changed in the face of growing populations, resource demand, and climate change. This study aimed to assess the decadal changes in the rice-cropping system in the Ayeyarwady Delta by using the large archive of satellite imagery for the last 40 years (1981 − 2020). The long-term NDVI dataset provided various information on rice cultivation. Signal processing techniques were used to detect on the historical changes in the rice-cropping system, and the impact of climate change was assessed by using trend analysis. Until the 1980s, single-cropping of summer rice was dominant in the Delta. To enhance the grain yield of rice, the irrigation facilities were introduced in 1992 under an initiative of the Myanmar government. As a result, the annual cropping intensities increased from 1.087 ± 0.390 in the 1980s to 1.422 ± 0.499 in the 2010s. The information on historical change in the rice-cropping system would be useful to consider the practical and cost-effective utilization of remaining land and water resources. Moreover, the trend analysis of NDVI time-series showed negative trends in coastal areas. This indicates that the rice production in coastal areas has been constrained by the saline intrusion. The salt-affected areas are expected to expand under future climate change scenarios. Government support is highly required for sustainable rice production in the Delta.
No evidence that nest site choice in Pied Flycatchers is mediated by assessing the clutch size of a heterospecific, the Great Tit
Authors: Slagsvold Tore , Wiebe Karen L.
Published: May 2021

Among species that use similar resources, an individual may benefit by observing and copying the behavioural decision of a heterospecific. We tested the hypothesis of heterospecific social learning in passerine birds, namely that a migrant species, the Pied FlycatcherFicedula hypoleuca,uses external markings on the nest cavities of a resident species, the Great TitParus major, as cues when choosing a nest site. Others have suggested that prospecting flycatchers assess the clutch size of tit “demonstrators” by entering their nest boxes and, assuming that a large clutch indicates a high-quality individual, will copy the nest appearance of tits with large, but not small clutches. During a 4-year period in Norway, we designed a similar study but did not find that flycatchers based their nest choice on the clutch size of tits. Neither were there any relationships between clutch size of the tit and its laying date, incubation behaviour, or the number of eggs visible through nest material during egg-laying so Pied Flycatchers did not use these indirect cues to assess quality of the tutor. Filming of tit nests showed that prospecting flycatchers did not enter tit nest boxes to assess the content. Indeed, incubating female tits only left their nest boxes for short bouts of unpredictable duration so there was little opportunity for flycatchers to inspect the nest contents unnoticed. Our study calls into question the mechanism of using the content of tit nests as public information for choosing traits of nest sites based on external characteristics. We suggest that similar studies of nest site choice in relation to possible social information transfer be replicated more widely.
Modeling cells spreading, motility, and receptors dynamics: a general framework
Authors: Serpelloni Mattia , Arricca Matteo , Bonanno Claudia , Salvadori Alberto
Published: May 2021

The response of cells during spreading and motility is dictated by several multi-physics events, which are triggered by extracellular cues and occur at different time-scales. For this sake, it is not completely appropriate to provide a cell with classical notions of the mechanics of materials, as for “rheology” or “mechanical response”. Rather, a cell is an alive system with constituents that show a reproducible response, as for the contractility for single stress fibers or for the mechanical response of a biopolymer actin network, but that reorganize in response to external cues in a non-exactly-predictable and reproducible way. Aware of such complexity, in this note we aim at formulating a multi-physics framework for modeling cells spreading and motility, accounting for the relocation of proteins on advecting lipid membranes.

Graphic Abstract

We study the mechanical response under compression/extension of an assembly composed of 8 helical rods, pin-jointed and arranged in pairs with opposite chirality. In compression we find that, whereas a single rod buckles (a), the rods of the assembly deform as stable helical shapes (b). We investigate the effect of different boundary conditions and elastic properties on the mechanical response, and find that the deformed geometries exhibit a common central region where rods remain circular helices. Our findings highlight the key role of mutual interactions in the ensemble response and shed some light on the reasons why tubular helical assemblies are so common and persistent.
Does the open-cell regime foster inmates’ legal capability? Evidence from two Italian prisons
Authors: Dalla Pellegrina Lucia , Saraceno Margherita
Published: May 2021

Evidence emerging from our novel in-prison survey shows that non-criminal legal problems of prison inmates mainly relate to family law matters, contract liability, and administrative procedures. The rate of subjects who face legal issues increases after imprisonment. Employing logit estimation techniques, we test the hypothesis according to which isolation due to imprisonment obstructs legal problem resolution. Results suggest that the open-cell regime has increased the rate of resolution of some family-related problems (divorce and child custody) while not affecting others (legacy issues). Similarly, while common problems with the public administration seem easier to solve under the open-cell regime, those related to contract liability do not. We infer that the open-cell regime may support the resolution of legal problems that usually require standardised approaches. Policy implications supporting the open-cell regime follow.
‘All things are in flux’: China in global science
Authors: Marginson Simon
Published: May 2021

Since 1990, a large and dynamic global science system has evolved, based on grass roots collaboration, and resting on the resources, infrastructure and personnel housed by national science systems. Euro-American science systems have become intensively networked in a global duopoly; and many other countries have built national science systems, including a group of large- and middle-sized countries that follow semi-autonomous trajectories based on state investment, intensive national network building, and international engagement, without integrating tightly into the global duopoly. The dual global/national approach pursued by these systems, including China, South Korea, Iran and India, is not always fully understood in papers on science. Nevertheless, China is now the number two science country in the world, the largest producer of papers and number one in parts of STEM physical sciences. The paper investigates the remarkable evolution of China’s science funding, output, discipline balance, internationalisation strategy and national and global networking. China has combined global activity and the local/national building of science in positive sum manner, on the ground of the nationally nested science system. The paper also discusses limits of the achievement, noting that while China-US relations have been instrumental in building science, a partial decoupling is occurring and the future is unclear.
Move or perish? Sticky mobilities in the Swiss academic context
Authors: Sautier Marie
Published: May 2021

This article uses a context of increasing institutional demand to be geographically mobile to examine how early-career researchers move across borders. I explore the case of Swiss academia, a particularly competitive and attractive environment with the highest levels of inbound and outbound mobility in Europe. In line with the aims of the European Research Area, an EU programme created in 2000 to foster a pan-European academic labour market, Switzerland funds scientific mobility and promotes extended research trips abroad as tools to boost collaboration and research excellence. Therefore, Swiss institutions have valued mobility for professional and personal development. In the meantime, they have raised concerns about female academics not being mobile and the potential consequences of their local family ties on career inequalities. In this study, I explore how early-career researchers experience mobility and how their personal accounts challenge institutional definitions of being mobile or immobile. I draw on a qualitative analysis of 65 semi-structured interviews conducted for two EU research projects on early-career academics from various backgrounds. I show how empirical data question the traditional—and often gendered—mobile/immobile dichotomy. I also highlight how mobility practices are normalised by the interviewees. Moreover, using the concept of stickiness, I describe a subtle range of sticky-to-stretchy mobility experiences influenced by both structural and individual factors. Finally, through the figure of the geoccasional worker, I question romanticised visions of mobility and stress the need to reconsider mobility as a (gendered) precarity issue rather than as a female problem.
Where are we in 2021 with heart failure with reduced ejection fraction?—current outlook and expectations from new promising clinical trials
Authors: Dębska-Kozłowska Agnieszka , Książczyk Marcin , Lelonek Małgorzata
Published: May 2021

Guideline-directed optimal medical therapy is a well-established therapy in treating patients with heart failure with reduced ejection fraction (HFrEF). Despite clear recommendations, the prognosis in this group of patients is still poor with high mortality. After publishing results of the PARADIGM-HF trial (Prospective Comparison of ARNI—Angiotensin Receptor/Neprilysin Inhibitors—with ACEI—Angiotensin-Converting Enzyme Inhibitor—to Determine Impact on Global Mortality and Morbidity in Heart Failure) clinical investigators accelerated their research. Recently, many new trials have been designed to evaluate the efficacy and safety of promising management, taking into account heterogeneity of population with chronic HFrEF. Determining target doses still poses the biggest problem in standard pharmacotherapy. Implementation of new substances for the HFrEF therapy makes it possible to formulate simple rules of treatment—in most cases, administering a dose of drug in one tablet provides a faster therapeutic effect. The aim of this article is to summarize current knowledge on recently announced findings on novel molecules and to propose a new revolutionary and individualised approach to treatment of HFrEF patients.
Bridging the gap between research and practice: using phenomenographic findings to develop training for career practitioners
Authors: Kettunen Jaana , Tynjälä Päivi
Published: May 2021

This study contends that phenomenography offers both a useful research method and practical tools for developing education and training for career practitioners. After introducing the basic principles of phenomenography, the study reviews previous research on its potential in developing pedagogical practices. It explores how the phenomenographic findings were utilized to design an online skills training programme for career practitioners. The study finds that phenomenographic research serves three practical pedagogical purposes: (1) revealing how learners understand certain concepts or phenomena, (2) elucidating how these understandings differ; and (3) identifying critical aspects in helping learners to widen and deepen their understanding.
Employees Receiving Inpatient Treatment for Common Mental Disorders in Germany: Factors Associated with Time to First and Full Return to Work
Authors: Sikora Alexandra , Schneider Gundolf , Wegewitz Uta , Bültmann Ute
Published: May 2021

Purpose In Germany, return to work (RTW) after inpatient treatment for common mental disorders (CMDs) is a complex process at the intersection of the mental healthcare system and the workplace. This study examined (1) the time to first and full RTW and (2) associated factors among employees receiving inpatient treatment for CMDs. Methods In this prospective cohort study, employees receiving inpatient psychiatric or medical rehabilitation treatment for CMDs were interviewed by phone during their last week before discharge. Follow-up interviews were conducted after 6, 12, and 18 months. Health-, personal, and work-related factors were used from baseline measurement. Parametric survival analysis was conducted to identify factors associated with time to first and full RTW. Results A total of N = 269 participants who stayed at a psychiatric clinic or a medical rehabilitation facility were included. Almost all participants (n = 252, 94%) from both treatment settings reported a first RTW and a full RTW. The time to first and full RTW was shortest among participants from medical rehabilitation (both median 6 days) and longer among participants from psychiatric treatment (median 17 days to first RTW and 73 days to full RTW). While only health-related and personal factors were associated with time to first RTW, leadership quality and needed individual RTW support were associated with time to full RTW. Conclusions More attention to work accommodation needs for RTW in clinical practice and coordinated actions towards RTW in collaboration with key RTW stakeholders in the workplace may support a timely RTW.

Clinical Registration Number DRKS00010903, retrospectively registered.
The Link Between COVID-19, Anxiety, and Religious Beliefs in the United States and the United Kingdom
Authors: Rigoli Francesco
Published: May 2021

Research has shown that stress impacts on people’s religious beliefs. However, several aspects of this effect remain poorly understood, for example regarding the role of prior religiosity and stress-induced anxiety. This paper explores these aspects in the context of the recent coronavirus pandemic (COVID-19). The latter has impacted dramatically on many people’s well-being; hence it can be considered a highly stressful event. Through online questionnaires administered to UK (n = 140) and USA (n = 140) citizens professing either Christian faith or no religion, this paper examines the impact of the coronavirus crisis upon common people’s religious beliefs. Anxiety about the coronavirus and prior religiosity showed an interaction effect upon change in religious beliefs (t(276) = 2.27,p = .024): for strong believers higher anxiety about coronavirus was associated with increased strengthening of religious beliefs (r = .249), while for non-believers higher anxiety about coronavirus was associated with increased scepticism towards religious beliefs (r = − .157). These observations are consistent with the notion that stress-induced anxiety enhances support for an individual’s existing ideology already embraced before a stressful event occurs. This study sheds light on the psychological and cultural implications of the coronavirus crisis, which represents one of the most serious health emergencies in recent times.
The inflammatory signalling mediator TAK1 mediates lymphocyte recruitment to lipopolysaccharide-activated murine mesenchymal stem cells through interleukin-6
Authors: Oelze Beatrice , Elger Kirsten , Schadzek Patrik , Burmeister Laura , Hamm Anika , Laggies Sandra , Seiffart Virginia , Gross Gerhard , Hoffmann Andrea
Published: May 2021

As a response to pro-inflammatory signals mesenchymal stem cells (MSCs) secrete agents and factors leading to lymphocyte recruitment, counteracting inflammation, and stimulating immunosuppression. On a molecular level, the signalling mediator TGF-β-activated kinase 1 (TAK1) is activated by many pro-inflammatory signals, plays a critical role in inflammation and regulates innate and adaptive immune responses as well. While the role of TAK1 as a signalling factor promoting inflammation is well documented, we also considered a role for TAK1 in anti-inflammatory actions exerted by activated MSCs. We, therefore, investigated the capacity of lipopolysaccharide (LPS)-treated murine MSCs with lentivirally modulated TAK1 expression levels to recruit lymphocytes. TAK1 downregulated by lentiviral vectors expressing TAK1 shRNA in murine MSCs interfered with the capacity of murine MSCs to chemoattract lymphocytes, indeed. Analysing a pool of 84 secreted factors we found that among 26 secreted cytokines/factors TAK1 regulated expression of one cytokine in LPS-activated murine MSCs in particular: interleukin-6 (IL-6). IL-6 in LPS-treated MSCs was responsible for lymphocyte recruitment as substantiated by neutralizing antibodies. Our studies, therefore, suggest that in LPS-treated murine MSCs the inflammatory signalling mediator TAK1 may exert anti-inflammatory properties via IL-6.
Feasibility of a combined supervised and home-based whole-body vibration intervention in children after inpatient oncological treatment
Authors: Daeggelmann J. , Otten S. , Prokop A. , Maas V. , Streckmann F. , Bloch W. , Oschwald V.
Published: May 2021

Purpose

Reduced physical performance due to therapy-related dysfunctions in children diagnosed with cancer contributes to insufficient physical activity levels. It is therefore essential that relevant functions are restored. Whole-body vibration (WBV) training, a neuromuscular stimulating exercise intervention, could have the potential to target those functions adequately. Therefore, the aim of this study was to evaluate the feasibility of a combined supervised and home-based WBV intervention with children after inpatient oncological treatment.

Methods

Eight children aged 6–21 years were included after cessation of their inpatient oncological treatment. They performed a 12-week WBV training including one supervised and two home-based sessions per week according to a standardized training protocol. Feasibility, adherence and compliance to the vibration protocol were documented. Subjective benefits and satisfaction were assessed using a questionnaire.

Results

Study participants attended 84.03 ± 13.09% of WBV sessions. No serious adverse events occurred. Some patients reported side effects partially resulting in modifications of the vibration protocol by therapists. Almost all children regarded the intervention as beneficial.

Conclusion

A combined supervised and home-based WBV intervention with children after inpatient oncological treatment is feasible and safe. The beneficial potential regarding relevant sensory and motor dysfunctions is now to be investigated.

Trial registration number and date of registration

DRKS00014713 15.05.2018
Semen quality as a potential susceptibility indicator to SARS-CoV-2 insults in polluted areas
Authors: Montano Luigi , Donato Francesco , Bianco Pietro Massimiliano , Lettieri Gennaro , Guglielmino Antonino , Motta Oriana , Bonapace Ian Marc , Piscopo Marina
Published: May 2021

The epidemic of the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has impacted worldwide with its infectious spread and mortality rate. Thousands of articles have been published to tackle this crisis and many of these have indicated that high air pollution levels may be a contributing factor to high outbreak rates of COVID-19. Atmospheric pollutants, indeed, producing oxidative stress, inflammation, immuno-unbalance, and systemic coagulation, may be a possible significant co-factor of further damage, rendering the body prone to infections by a variety of pathogens, including viruses. Spermatozoa are extremely responsive to prooxidative effects produced by environmental pollutants and may serve as a powerful alert that signals the extent that environmental pressure, in a specific area, is doing damage to humans. In order to improve our current knowledge on this topic, this review article summarizes the relevant current observations emphasizing the weight that environmental pollution has on the sensitivity of a given population to several diseases and how semen quality, may be a potential indicator of sensitivity for virus insults (including SARS-CoV-2) in high polluted areas, and help to predict the risk for harmful effects of the SARS-CoV-2 epidemic. In addition, this review focused on the potential routes of virus transmission that may represent a population health risk and also identified the areas of critical importance that require urgent research to assess and manage the COVID-19 outbreak.
Orientation effect of electropolishing characteristics of 316L stainless steel fabricated by laser powder bed fusion
Authors: Han Wei , Fang Fengzhou
Published: May 2021

3D metal printing process has attracted increasing attention in recent years due to advantages, such as flexibility and rapid prototyping. This study aims to investigate the orientation effect of electropolishing characteristics on different surfaces of 316L stainless steel fabricated by laser powder bed fusion (L-PBF), considering that the rough surface of 3D printed parts is a key factor limiting its applications in the industry. The electropolishing characteristics on the different surfaces corresponding to the building orientation in selective laser melting are studied. Experimental results show that electrolyte temperature has critical importance on the electropolishing, especially for the vertical direction to the layering plane. The finish of electropolished surfaces is affected by the defects generated during L-PBF process. Thus, the electropolished vertical surface has higher surface roughness Sa than the horizontal surface. The X-ray photoelectron spectroscopy spectra show that the electropolished horizontal surface has higher Cr/Fe element ratio than the vertical surface. The electropolished horizontal surface presents higher corrosion resistance than the vertical surface by measuring the anodic polarization curves and fitting the equivalent circuit of experimental electrochemical impedance spectroscopy.
The size–growth relationship in the social services sector in Austria
Authors: Reitzinger Stephanie , Pennerstorfer Astrid
Published: May 2021

The social services sector is among the fastest-growing industries, but it has gained little attention in the debate regarding firm growth. This article analyzes firm growth in relation to firm size using payroll expenses as our indicator for both firm growth and firm size. We apply structural equation modeling and full maximum likelihood estimation using Austrian data comprising all non-profit social service providers. After 2013, fewer firms have been entering and more have been exiting the sector; however, we find that growing in size is still not associated with higher growth rates. Our study emphasizes the role of small organizations in remaining a growth sector.
An analysis of the cost of postgraduate training in surgery in Ireland compared to other specialties
Authors: H. Earley , K. Mealy
Published: May 2021

Introduction

Postgraduate specialty training in Ireland is associated with considerable cost. Some of these are mandatory costs such as medical council fees, while others are necessary to ensure career progression, such as attendance at courses and conferences. In particular, surgical specialities are believed to be associated with high training costs. It is unknown how these costs compare to those borne by counterparts in other specialities.

Aims

The aims of this study were to

Quantify the amount that trainees in Ireland spend on postgraduate training

Determine whether a difference exists between surgery and other non-skill-based specialties in terms of expenditure on training

Methods

A standardised non-mandatory questionnaire was circulated to trainees across two training centres in Ireland. Trainees at all levels were invited to participate.

Results

Sixty responses were obtained. Fifty-seven questionnaires were fully completed and included for analysis. The median expenditure on training was higher for surgical than non-surgical specialities. Subgroup analysis revealed surgical training was associated with higher expenditure on higher degrees and courses compared to medical training (p = 0.035). > 95% of trainees surveyed felt that greater financial support should be available for trainees during the course of their training.

Conclusions

This study demonstrated that a career in surgery is associated with higher ongoing costs for higher degrees and courses than counterparts in non-surgical training. All surgical trainees surveyed felt that better financial support should be available. Increasing financial support for may be a tangible way to mitigate against attrition during training.
The role of unconventional T cells in COVID-19
Authors: Orumaa Kristen , Dunne Margaret R.
Published: May 2021

COVID-19 is a respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first documented in late 2019, but within months, a worldwide pandemic was declared due to the easily transmissible nature of the virus. Research to date on the immune response to SARS-CoV-2 has focused largely on conventional B and T lymphocytes. This review examines the emerging role of unconventional T cell subsets, including γδ T cells, invariant natural killer T (iNKT) cells and mucosal associated invariant T (MAIT) cells in human SARS-CoV-2 infection.

Some of these T cell subsets have been shown to play protective roles in anti-viral immunity by suppressing viral replication and opsonising virions of SARS-CoV. Here, we explore whether unconventional T cells play a protective role in SARS-CoV-2 infection as well. Unconventional T cells are already under investigation as cell-based immunotherapies for cancer. We discuss the potential use of these cells as therapeutic agents in the COVID-19 setting. Due to the rapidly evolving situation presented by COVID-19, there is an urgent need to understand the pathogenesis of this disease and the mechanisms underlying its immune response. Through this, we may be able to better help those with severe cases and lower the mortality rate by devising more effective vaccines and novel treatment strategies.
Roles of Immune Cells in Hereditary Angioedema
Authors: Ferrara Anne Lise , Cristinziano Leonardo , Petraroli Angelica , Bova Maria , Gigliotti Maria Celeste , Marcella Simone , Modestino Luca , Varricchi Gilda , Braile Mariantonia , Galdiero Maria Rosaria , Spadaro Giuseppe , Loffredo Stefania
Published: May 2021

Hereditary angioedema (HAE) is a rare genetic disease, characterized by recurrent and unexpected potentially life-threatening mucosal swelling. HAE may be further classified into HAE with C1‐inhibitor deficiency (C1‐INH‐HAE) and HAE with normal C1‐INH activity (nlC1‐INH‐HAE), mostly due to mutations leading to increased vascular permeability. Recent evidence implicates also the innate and adaptive immune responses in several aspects of angioedema pathophysiology. Monocytes/macrophages, granulocytes, lymphocytes, and mast cells contribute directly or indirectly to the pathophysiology of angioedema. Immune cells are a source of vasoactive mediators, including bradykinin, histamine, complement components, or vasoactive mediators, whose concentrations or activities are altered in both attacks and remissions of HAE. In turn, through the expression of various receptors, these cells are also activated by a plethora of molecules. Thereby, activated immune cells are the source of molecules in the context of HAE, and on the other hand, increased levels of certain mediators can, in turn, activate immune cells through the engagement of specific surface receptors and contribute to vascular endothelial processes that lead to hyperpemeability and tissue edema. In this review, we summarize recent developments in the putative involvement of the innate and adaptive immune system of angioedema.
Stress testing supply chains and creating viable ecosystems
Authors: Ivanov Dmitry , Dolgui Alexandre
Published: May 2021

Businesses and governments are becoming increasingly concerned about the resilience of supply chains and calling for their review and stress testing. In this conceptual essay, we theorize a human-centred ecosystem viability perspective that spans the dimensions of resilience and sustainability and can be used as guidance for the conceptualization of supply chain resilience analysis in the presence of long-term crises. Subsequently, we turn to the technological level and present the digital supply chain twin as a contemporary instrument for stress testing supply chain resilience. We provide some implementation guidelines and emphasize that although resilience assessment of individual supply chains is important and critical for firms, viability analysis of intertwined supply networks and ecosystems represents a novel and impactful research perspective. One of the major outcomes of this essay is the conceptualization of a human-centred ecosystem viability perspective on supply chain resilience.
Effects of Heat Stress on Gut Microbiome in Rats
Authors: Qu Qian , Li Hua , Bai Lin , Zhang Shiwei , Sun Jiaqi , Lv Weijie , Ye Chunxin , Liu Cui , Shi Dayou
Published: May 2021

Gut microbiome, as the largest and most important micro-ecosystem, plays a critical role in health. The purpose of this study was to evaluate whether heat stress modulates the composition and diversity of the gut microbiome in rats. The heat stress model was prepared in rats with the heating temperature maintained at 35–38°C. Cecum contents were collected after heat stress for 3 h and days 1, 3 and 7. Total DNA was extracted for 16 S rRNA sequencing and analysis of intestinal microbiome composition and diversity. The study showed that the composition of the intestinal microbiome of heat stress group was changed. And the heat stress modulated key phylotypes of gut microbiota at the level of phylum and genus. In particular, the genus of Lactobacillus and Bacteroides were significantly reduced, whereas the Oscillospira and Clostridium were increased by heat stress. Meanwhile, the rats under the heat stress encountered the change in carbohydrate metabolism, amino acid metabolism, and membrane transport to defense against stress. Taken together, the composition and structure of gut microbiome were affected by heat stress and some key phylotypes were also significantly altered. We conclude that the heat stress could impact multiple biological functions, via altering the gut microbiome.
UBCG2: Up-to-date bacterial core genes and pipeline for phylogenomic analysis
Authors: Kim Jihyeon , Na Seong-In , Kim Dongwook , Chun Jongsik
Published: May 2021

Phylogenomic tree reconstruction has recently become a routine and critical task to elucidate the evolutionary relationships among bacterial species. The most widely used method utilizes the concatenated core genes, universally present in a single-copy throughout the bacterial domain. In our previous study, a bioinformatics pipeline termed Up-to-date Bacterial Core Genes (UBCG) was developed with a set of bacterial core genes selected from 1,429 species covering 28 phyla. In this study, we revised a new bacterial core gene set, named UBCG2, that was selected from the more extensive genome sequence set belonging to 3,508 species spanning 43 phyla. UBCG2 comprises 81 genes with nine Clusters of Orthologous Groups of proteins (COGs) functional categories. The new gene set and complete pipeline are available at http://leb.snu.ac.kr/ubcg2.