COVID-19 INFECTION IN PATIENTS WITH PRIMARY IMMUNODEFICIENCIES
Authors:   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Kan N.Yu. , Mukhina A.A. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Rodina Yu.A. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Kuzmenko N.B. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Deordieva E.A. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Kozlova A.L. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Deripapa E.V. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Roppelt A.A. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Khoreva A.L. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Moiseeva A.A. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Burlakov V.I. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Viktorova E.A. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Shvets O.A. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Nesterenko Z.A. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Latysheva E.A. ,   National Research Center Institute of Immunology of the Russian Federal Biomedical Agency, Moscow, Russia, Latysheva T.V. ,   National Research Center Institute of Immunology of the Russian Federal Biomedical Agency, Moscow, Russia, Frolov E.A. ,   National Research Center Institute of Immunology of the Russian Federal Biomedical Agency, Moscow, Russia, Kuznetsova R.N. ,   Pasteur Institute of Epidemiology and Microbiology, Saint Petersburg, Russia, Totolian A.A. ,   Pasteur Institute of Epidemiology and Microbiology, Saint Petersburg, Russia, Milichkina A.M. ,   Pasteur Institute of Epidemiology and Microbiology, Saint Petersburg, Russia, Vlasova E.V. ,   Sverdlovsk Oblast Regional Children’s Clinical Hospital No. 1, Yekaterinburg, Sverdlovsk Oblast, Russia, Zinovieva N.V. ,   G.N. Speransky City Children’s Hospital No. 9, Moscow, Russia, Zimin S.B. ,   G.N. Speransky City Children’s Hospital No. 9, Moscow, Russia, Konstantinova A.K. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Richkova O.A. ,   Tyumen State Medical University, Tyumen, Russia, Kuzmicheva K.P. ,   Tyumen State Medical University, Tyumen, Russia, Semenyuk E.N. ,   Tyumen Regional Infectious Diseases Clinical Hospital, Tyumen, Russia, Fomina D.S. ,   Center for Allergology and Immunology with the Moscow City Clinical Hospital No. 52 of the Moscow Department of Healthcare, Moscow, Russia, Fisun I.V. ,   Z.I. Kruglaya Scientific and Clinical Multidisciplinary Center for Mother and Child Medical Care, Orel, Russia, Selezneva O.S. ,   Rostov Regional Children's Clinical Hospital, Rostov-on-Don, Russia, Novichkova G.A. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Shcherbina A.Yu. ,   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia
Published: November 2020

The article presents data on the features of COVID-19 infection in patients with primary immunodeficiencies (PIDs) in the Russian Federation, obtained through the National association of experts in PID (NAEPID) registry. Materials and methods: from March 1, 2020 to October 15, 2020, 15 cases of close intrafamilial contact between PIDs patients and COVID-19 patients without reliable infection of the first and 23 cases of COVID-19 infection in PIDs patients were reported. Results: 6/23 infected people had asymptomatic course of infection, 9/23 patients – mild form, 8/23 – moderate form of disease, one patient had a severe course with a fatal outcome. 19/23 patients were under 18 years of age, which corresponds with the age data of the national Russia PID registry. Conclusion: perhaps this age composition partially explains the milder course of COVID-19 in PIDs patients compared to the European data. Other possible reasons for a milder course may be the lower pathogenicity of the coronavirus strain circulating in the Russian Federation.