bluuebunny/crossref_metadata_2025 huggingface dataset:
Edukasi model pembelajaran pada Kurikulum Merdeka terintegrasi dengan dimensi pertama Profil Pelajar Pancasila
Authors: Nurmitasari  , Nihayati  , Kayyis Rahmatika
Published: November 2023

Tujuan dari Program Pengabdian Kepada Masyarakat (PKM) ini adalah untuk memberikan edukasi kepada guru-guru di SD di Kecamatan Ambarawa tentang model pembelajaran pada kurikulum merdeka yang terintegrasi dengan nilai keislaman. Metode kegiatan PKM yang dilaksanakan terdiri dari tahap persiapan, tahap pelaksanaan, dan tahap evaluasi. Kegiatan pada tahap persiapan yaitu observasi sekolah, menganalisis permasalahan disekolah, merancang solusi terhadap permasalahan, merancang google sites tentang materi, kuesener yang disusun dengan google form, dan mendata guru. Kegiatan pada tahap pelaksanaan yaitu memberi informasi dalam bentuk edukasi tentang bagaimana mengimplementasi model pembelajaran pada kurikulum merdeka yang terintegrasi dengan nilai keislaman . Kegiatan pada tahap evaluasi yaitu guru mempraktikan model pembelajaran sesuai kurikulum merdeka secara langsung. Hasil dari pengabdian ini adalah pelatihan ini selain mendapatkan respon yang baik juga dinilai dapat meningkatkan   pengetahuan   dan   kemampuan   guru   SD  di kecamatan Ambarawa dalam melaksanakan  proses  pembelajaran. Implikasi  pengabdian ini nantinya dapat digunakan oleh guru untuk memperbaiki pembelajaran di kelas menuju kurikulum yang berpihak pada siswa, kurikulum merdeka.
Pendampingan pengenalan slang word menggunakan aplikasi media sosial tiktok pada anak-anak Kp.Golat Desa Pangkalan
Authors: Jamaludin Anang Jamaludin
Published: November 2023

Penelitian ini bertujuan untuk menginvestigasi efek dari adanya bahasa gaul yang terdapat pada media sosial tiktok terhadap peningkatan pengetahuan  anak-anak dalam memahami bahasa gaul. Metode penelitian yang digunakan adalah metode ceramah dengan desain deskriptif  pada sekelompok anak warga Kp.Golat. Kegiatan Pendampingan ini dirancang untuk memberikan pemahaman  dan pengetahuan mengenai Slang Word sebagai bahasa pendukung untuk mengantisipasi pesatnya perkembangan zaman dan teknologi.Data dikumpulkan melalui observasi partisipasi dalam kegiatan. Hasil analisis menunjukkan peningkatan yang signifikanpada anak-anak  dalam pemahaman terhadap bahasa gaul . Implikasi dari penelitian ini adalah pentingnya pemahaman dan pengetahuan berbahasa terutama bahasa gaul  dalam  upayaa meningkatkan kemampuan berbahasa pada anak
Keterampilan mengajar guru di Lembaga Pendidikan Al-Ma’arif Kuningan
Authors: Zahrah Riza
Published: November 2023

Al-Ma'arif educational institution stands as many as three educational institutions, namely PAUD Al- Ma'arif, TPA / TKA Al-Ma'arif and DTA Al-Ma'arif. Al-Ma'arif Educational Institution encounters obstacles including aspects of human resources who have educational qualifications that are not in accordance with the field of science or education. Then motivation, innovation and creativity are still low which has implications for the process of organizing ongoing education and teaching. Improving HR aspects in improving HR teaching skills in the learning process in the classroom. Activities to improve HR teaching skills that will have implications for HR innovation and creativity after the development of lesson plan preparation activities and audio-visual media. The output targets to be achieved include: Teaching skills of educators, creativity and innovation of educators in the learning process to improve student learning outcomes and the creation of a pleasant learning atmosphere. The implementation method used in this PKM activity includes the method of technology transfer and continuous assistance.
Pendampingan pengembangan keterampilan Guru Madrasah untuk pembuatan konten pembelajaran digital
Authors: Mudiyanto Heru , Jaelani Aceng
Published: November 2023

ABSTRAK

Guru dituntut untuk bisa beradaptasi dalam pembelajaran di era digital ini. Oleh karena itu, Guru harus memiliki keterampilan pembelajaran salah satunya yaitu membuat konten pembelajaran digital . Tujuan dari pengabdian ini adalah untuk melakukan Pendampingan pengembangan keterampilan guru madrasah untuk pembuatan konten pembelajaran digital. Metode pengabdian yang digunakan dalam pengabdian ini adalah metode ABCD (Asset Based Community Development). Adapun target pengabdian ini adalah Guru MI/SD, MTs/ SMP, dan MA / SMA di Indonesia dengan jumlah peserta 75 guru dari berbagai daerah. Hasil pengabdian ini menunjukkan bahwa : 1) Pelaksanaan Pengabdian sudah sesuai dengan metode ABCD yaitu Discovery (Pengkajian), Dream (Impian), Design (prosedur), Define (Pemantapan Tujuan) dan Destiny (Self Determination). 2) Setelah dilakukan pelatihan, sebanyak 47 % peserta telah membuat konten pembelajaran digital.

Kata Kunci : pembelajaran digital, guru madrasah, konten pembelajaran digital.

 

ABSTRACT

Teachers are required to be able to adapt in learning in this digital era. Therefore, teachers must have learning skills, one of which is creating digital learning content. The purpose of this service is to provide assistance for the development of madrasah teacher skills for the creation of digital learning content. The service method used in this service is the ABCD (Asset Based Community Development) method. The target for this service is MI / SD, MTs / SMP, and MA / SMA teachers in Indonesia with 75 teacher participants from various regions. The results of this dedication show that: 1) The implementation of the Community Service is in accordance with the ABCD method, namely Discovery (Study), Dream (Dream), Design (procedure), Define (Strengthening Goals) and Destiny (Self Determination). 2) After the training, as many as 47% of participants have created digital learning content. Keywords: digital learning, madrasa teacher, digital learning content.
Eficácia e segurança de rotigotina, comparada a outros agonistas dopaminérgicos disponíveis no SUS, para o tratamento da doença de Parkinson: revisão rápida de evidências.
Authors: Lima Paulo Marcelo de Andrade , Tomich Lísia Gomes Martins de Moura , Caetano Rafaella de Carvalho , Silva Hidelberto Matos
Published: November 2023

Tecnologia: Rotigotina e outros medicamentos antiparkinsonianos, com ênfase em agonistas dopaminérgicos (bromocriptina e pramipexol). Indicação: Tratamento da doença de Parkinson. Pergunta: Há superioridade de eficácia e segurança da rotigotina, comparado aos agonistas dopaminérgicos disponíveis atualmente no SUS para o tratamento da doença de Parkinson? Métodos: Revisão rápida de evidências (overview) de revisões sistemáticas, com levantamento bibliográfico realizado na base de dados PubMed e utilizando estratégia estruturada de busca. A qualidade metodológica das revisões sistemáticas foi avaliada com AMSTAR-2 (Assessing the Methodological Quality of Systematic Reviews Version 2). Resultados: Foram selecionadas três revisões sistemáticas que atendiam aos critérios de inclusão. Conclusão: A rotigotina não apresenta eficácia e segurança superiores ao pramipexol; não há quantidade de estudos suficientes para comparação com a bromocriptina.
Qualidade de vida de pacientes afásicos pós acidente vascular cerebral.
Authors: Amaral Cláudia Maria Silva Ribeiro , Santos Karlos Thiago Pinheiro dos
Published: November 2023

Introdução: Cerca de um terço da população acometida por Acidente Vascular Cerebral (AVC) pode desencadear afasia, sendo esta caracterizada pela perda ou comprometimento da função de linguagem, podendo causar prejuízos na compreensão, emissão da fala, habilidades de leitura, escrita e numéricas, considerada um preditor importante de sofrimento emocional e qualidade de vida (QV) negativa. Objetivo: Avaliar aspectos da QV de pacientes afásicos pós AVC. Método: Estudo quantitativo, observacional, analítico e transversal realizado em um centro de reabilitação. Os critérios de inclusão foram idade acima de 18 anos, de ambos os sexos e excluídos pacientes com tempo de lesão menor que 6 meses, com história pregressa de doenças psiquiátricas e/ou condições neurológicas progressivas concomitantes. Foram coletados os dados sociodemográficos, as variáveis clínicas e aplicado o questionário SAQOL-39. Para análise estatística foi considerado o nível de 5% de significância. Resultados: Dos 33 participantes, 54,5% eram do sexo feminino, com prevalência de idade de 28 a 49 anos (45,5%), majoritariamente indivíduos casados (54,5%), tendo o cônjuge como o principal cuidador (58,1%). O domínio mais afetado foi o da comunicação (2,23) e o Energia (3,15) o menos afetado. Foi observado relevância significativa entre QV e faixa etária, sexo, tipo de AVC, o não uso de cadeira de rodas e alterações motoras. Conclusão: Entre as diversas sequelas provenientes do AVC em afásicos, que influenciam diretamente no bem-estar geral, a comunicação parece ser a habilidade que mais impacta na QV destes indivíduos.
Recorte raça/cor dos indicadores materno-infantis em uma regional de saúde do estado de Goiás.
Authors: Matos Luana da Silva , Assis Thaís Rocha , Sousa Sterlanny Reisde , Passos Vânia Marra , Silva Gecirlei Franciscoda
Published: November 2023

Objetivos: Este estudo teve como objetivo avaliar indicadores materno-infantis da Regional Nordeste I de Goiás entre 2011 e 2021. Métodos: Trata-se de um estudo ecológico, com coleta de dados secundários do Departamento de Informática do Sistema Único de Saúde (DATASUS). Foram realizadas estatísticas descritiva e analítica dos indicadores materno-infantis da regional, com comparação entre os grupos de raça/cor. Essa regional de saúde é composta por três municípios que possuem grande concentração de comunidades quilombolas. Resultados: Observou-se piora dos indicadores materno-infantis nas mulheres pretas, com maiores porcentagens de partos pós-termo e filhos com baixo peso ao nascer, quando comparadas às mulheres brancas e pardas. Apenas 54,56% das gestantes realizaram 6 ou mais consultas de pré-natal, o que provavelmente foi a causa de uma alta prevalência de sífilis congênita na região. A baixa adesão também foi notada nas consultas de puerpério e puericultura. Conclusões: A falta de adesão das gestantes e mães às consultas de pré-natal, puerpério e puericultura foi a principal falha observada na regional. A falta de vínculo entre equipes de saúde e usuárias do SUS, alta prevalência de famílias carentes e de residentes de zonas rurais na região dificultam o acesso aos serviços de saúde e a continuidade do cuidado, levando a essa baixa adesão aos serviços.
Aggressive aerosol mitigation policies reduce chances of keeping global warming to below 2C
Authors: Wood Robert , Vogt Mika , McCoy Isabel Louise
Published: November 2023

Aerosol increases over the 20th century delayed the rate at which Earth
warmed as a result of increases in greenhouse gases (GHGs). Aggressive
aerosol mitigation policies arrested aerosol radiative forcing from
~1980 to ~2010. Recent evidence supports
decreases in forcing magnitude since then. Using the approximate partial
radiative perturbation (APRP) method, future shortwave aerosol effective
radiative forcing changes are isolated from other shortwave changes in
an 18-member ensemble of ScenarioMIP projections from phase 6 of the
Coupled Model Intercomparison Project (CMIP6). APRP-derived near-term
(2020-2050) aerosol forcing trends are correlated with published model
emulation values but are 30-50% weaker. Differences are likely
explained by location shifts of aerosol-impacting emissions and their
resultant influences on susceptible clouds. Despite weaker changes,
implementation of aggressive aerosol cleanup policies will have a major
impact on global warming rates over 2020-2050. APRP-derived aerosol
radiative forcings are used together with a forcing and impulse response
model to estimate global temperature trends. Strong mitigation of GHGs,
as in SSP1-2.6, likely prevents warming exceeding 2C since preindustrial
but the strong aerosol cleanup in this scenario increases the
probability of exceeding 2C by 2050 from near zero without aerosol
changes to 6% with cleanup. When the same aerosol forcing is applied to
a more likely GHG forcing scenario (i.e., SSP2-4.5), aggressive aerosol
cleanup more than doubles the probability of reaching 2C by 2050 from
30% to 80%. It is thus critical to quantify and simulate the impacts
of changes in aerosol radiative forcing over the next few decades.
Computational modelling of micro-structured burners with improved combustion stability by fluid recirculation structures
Authors: Brown Christopher , Chen Junjie
Published: November 2023

While burners designed in a backflow way enable operation with very low
noxious emissions, they frequently operate very close to the extinction
limit of the flame. Cavity structures have been designed for the purpose
of improving flame stability. However, the precise mechanism by which
the cavity method provides increased flame stability remains unclear.
Computational fluid dynamics simulations are conducted to gain insights
into burner performance such as reaction rates, species concentrations,
temperatures, and flames. Factors affecting combustion characteristics
and flame stability are determined. The results indicate that burner
dimensions greatly affect flame stability. Burners with large dimensions
lead to a delay in flame ignition and may cause blowout. The combustion
is stabilized by recirculation of hot combustion products induced by the
cavity structure. The inlet velocity of the mixture is a critical factor
in assuring flame stability within the cavity-stabilized burner. There
is a narrow range of inlet velocities that permit sustained combustion
within the cavity-stabilized burner. Design recommendations are
provided.

Keywords: Burners; Flames; Temperatures; Species
concentrations; Reaction rates; Combustion
Stellate Ganglion Block for the treatment of olfactory and gustatory dysfunction in patients with Long COVID: Case Series
Authors: Bayramov Tural
Published: November 2023

Weeks or months after recovering from COVID-19, a significant number of
people are still experiencing fatigue, ‘brain fog’, headaches, cognitive
impairment, smell or taste disturbances, myalgia and one or more other
symptoms. This condition has been termed as Long COVID and dysautonomia
is thought to play one of the important roles in the pathophysiology of
this condition. The stellate ganglion block (SGB) is thought to restore
autonomic nervous system functioning by temporarily inhibiting cervical
sympathetic activity and is under investigation as a potential option
for the treatment of persistent olfactory and gustatory dysfunction,
headache and other symptoms of Long COVID. In this case series, we
report that by performing SGB, we successfully treated and improved the
quality of life of two patients with a Long COVID diagnosis who
presented us with complaints of smell and taste sensory impairment.
Thrombin Activatable Fibrinolysis Inhibitor (TAFI) Plasma Levels and Thr325Ile Genetic Polymorphism in a Cohort of Egyptian Sickle Cell Disease Patients and Impact on Disease Severity
Authors: Selim Yasmeen , Hamdy Mona , Shaheen Iman , Khallaf Mohamed
Published: November 2023

Background: Thrombin is a critical protease modulating
thrombosis as well as inflammation which are one of the main
pathophysiological mechanisms in sickle vasculopathy, and its levels
were reported to be high in sickle cell disease (SCD). The
thrombin-thrombomodulin complex activates an inhibitor of fibrinolysis
called TAFI acting by reducing plasmin affinity for its substrate
hindering fibrinolysis. Objective: We aimed to determine the
influence of the Thr325Ile single nucleotide polymorphism on TAFI
antigen levels and potential effects on the severity of SCD in a cohort
of Egyptian patients. Methods: Genotyping of Thr325lle
polymorphism using Taq-Man SNP genotyping assay and TAFI level
measurement using an Enzyme-Linked Immunosorbent Assay (ELISA) were
performed for 80 SCD patients and 80 health control subjects.
Results: Plasma TAFI levels were higher in SCD patients with
Thr325Ile polymorphism, yet the difference was not statistically
significant (p=0.204). SCD patients with polymorphic genotypes had a
greater number of hospital admissions (p=0.03), Ten patients with acute
chest syndrome had the homozygous polymorphic genotype (GG), and all
patients with pulmonary hypertension had the polymorphic genotype (6
were homozygous [GG] and 5 were heterozygous [GA]). SCD patients
complicated with pulmonary hypertension showed significantly higher
plasma TAFI levels (p= 0.044). Conclusion: The analysis of
Thr325Ile polymorphism combined with plasma TAFI level possibly suggests
that the analyzed SNP could influence plasma levels and subsequently
disease severity and hospitalization rate, which might be regarded as
predictors for complex disease.
A nomogram with Ki-67 in the prediction of postoperative recurrence and death for glioma
Authors: Li Fengfeng , Wang Dongyuan , Wang Nana , Wu Linlin , Yu Bo
Published: November 2023

Background: To evaluate the predictive value of a nomogram with Ki-67 in
overall and disease-free survival in glioma patients. Methods: A total
of 76 patients diagnosed with glioma were enrolled. The baseline data
and followups were retrospectively collected from medical records. The
associations between Ki-67 and survival status were examined using
log-rank test, univariate and multivariate Cox proportional hazard
regression models. Calibrations were performed to validate the
established nomograms. Results: Ki-67 negative group showed a longer OS
survival time and a longer PFS survival time with log-rank test
(x2=16.101, P<0.001 and x2=16.961, P<0.001). Age
older than 50 years (HR=2.074, 95% CI: 1.097-3.923), abnormal treatment
(HR=2.932, 95% CI: 1.343-6.403) and Ki-67 positive (HR=2.722, 95% CI:
1.097-6.755) were the independent predictive factors of death. High
grade pathology (HR=2.453, 95% CI: 1.010-5.956) and Ki-67 positive
(HR=2.200, 95% CI: 1.043-4.639) were the independent predictive factors
of recurrence. The C-index for the nomogram of OS and PFS were 0.745 and
0.723, respectively. The calibration results showed that the nomogram
could predict the overall and disease-free 1-year survival of glioma
patients. Conclusion: The nomograms with Ki-67 as independent risk
factor for OS and PFS could provide clinical consultation in the
treatment and follow-up of malignant glioma.
Knowledge Mapping of Rural Elderly Health Research - A CiteSpace Bibliometric Analysis Based on the WOS Database
Authors: li feifei
Published: November 2023

Using CiteSpace 6.1.R6 bibliometrics software, we retrospectively
analysed and mapped 1,184 articles in WOS in terms of co-citation,
authors, institutions, keyword co-occurrence, keyword emergence, and
keyword frequency, to summarize the hotspots and trends of the research
on the health of the rural elderly, and to provide a basis for the
research on the health of the rural elderly. The results of the analyses
show that: (1) the research on the health of the rural elderly generally
shows an annual trend of “fluctuating upward”. (2) The
inter-institutional and inter-authorship collaborations show low network
density and intermediary centrality, with fragmented research efforts
and fewer collaborative achievements. (3) There are some differences in
the research hotspots of rural elderly health, but the keyword cluster
analysis shows that the research hotspots involve more areas. In the
future, we should continue to broaden the depth and breadth of rural
elderly health research.
Lumped-element Equivalent Circuit Modeling of District Heating Pipe in Electromagnetic Transient Programs
Authors: Jiang Mingyu , Xia yue , Lan Tian , Song Ruikai , Du songhuai , Su Juan
Published: November 2023

Electromagnetic transients program (EMTP) is widely used to analyse
transients in power systems. With the increasing interest in integrated
energy systems (IESs), it would be beneficial to extend the application
of EMTP to multi-physics transients in integrated electrical and heating
networks. In this paper, an accurate and efficient lumped-element
circuit model of the heating district pipe is developed in EMTP. The
pipe is split into segments using spatial discretisation. The
application of the numerical discretisation to the energy conservation
equation gives the discretised pipe equation which is expressed in the
form of a companion model of EMTP. In order to reduce the computational
effort, the time-varying terms in the admittance matrix of the companion
model of pipe are eliminated. The modification of the admittance matrix
is avoided. Furthermore, the internal nodes resulting from spatial
discretisation are eliminated, and the pipe model appears as a
lumped-element circuit with two external nodes. Case studies are carried
out to verify the accuracy and efficiency of the proposed lumped-element
circuit model of pipe. The implementation of the proposed pipe model in
the EMTP-type simulator enables the analysis of multi-physics transients
in a multi-carrier energy system.
A Comprehensive Systematic Review of Intra-Articular Corticosteroids: Effects of Multiple Injections and Different Doses (Part 2)
Authors: Tokawa Paula Keiko Anadão , Baccarin Raquel , Zanotto Gustavo
Published: November 2023

Background: Corticosteroids are commonly used for
intra-articular (IA) treatment of osteoarthritis (OA) in horses;
however, there is controversy regarding its use as a multiple-injection
treatment and for the appropriate dosing. Objectives: This
systematic review collected and critically appraised the current
evidence regarding the effects of multiple injections and various doses
of corticosteroids for treating osteoarthritis. Study design:
Systematic review. Methods: Titles of published articles up to
June/2022 generated by searches in PubMed, CAB, and the Web of Science
were screened using general inclusion criteria. Each question for
corticosteroid effects (multiple treatments and different doses) had
further inclusion requirements. The risk of bias was assessed according
to the study design. Results: Of 6,417 titles generated by the
systematic search, only nine met all inclusion criteria for
multiple-injection treatments, and 14 were included for screening the
effects of various doses. Most studies showed unclear/high risk of bias.
Multiple-injection protocols showed better symptom-modifying changes at
first injections with decreased improvements. Disease-modifying changes
improved over shorter follow-ups; however, degenerative changes were
seen in the longer term. Determining the dose effect of corticosteroids
was challenging regarding different doses because there were few
in vivo studies. In vitro, lower doses appeared to be
safer for articular tissues. Main limitations: Lack of studies
regarding the topics. Conclusions: No benefits but drawbacks of
multiple IA injections in the long term were found in this review, and
results regarding the dose of corticosteroids in OA joints were not
consistent in in vivo, but in vitro, studies pointed out
that lower doses might be safer for joint tissues.
Octadecyl and sulfonyl modification of diatomite synergistically improved the immobilization efficiency of lipase and its application in the synthesis of pine sterol esters
Authors: Zhang Yifei , Zhang Wei , Ma Guangzheng , Nian Binbin , Hu Yi
Published: November 2023

Phytosterols usually have to be esterified to various phytosterol esters
to avoid their disadvantages of unsatisfactory solubility and low
bioavailability. The enzymatic synthesis of phytosterol esters in
solvent-free system has advantages in terms of environmental
friendliness, sustainability, and selectivity. However, the limitation
of the low stability and recyclability of the lipase in the solvent-free
system, which often requires a relatively high temperature to induce the
viscosity, also increased the industrial production cost. In this
context, a low-cost material, namely diatomite, was employed as the
support in the immobilization of Candida rugosa lipase (CRL) due to its
multiple modification sites. The Fe3O4 was also then introduced to this
system for quick and simple separation via the magnetic field. Moreover,
to further enhance the immobilization efficiency of diatomite, a
modification strategy which involved the octadecyl and sulfonyl group
for regulating the hydrophobicity and interaction between the support
and lipase was successfully developed. The optimization of the ratio of
the modifiers suggested that the -SO3H/C18 (1:1.5) performed best with
an enzyme loading and enzyme activity of 84.8 mg·g-1 and 54 U·g-1,
respectively. Compared with free CRL, the thermal and storage stability
of CRL@OSMD was significantly improved, which lays the foundation for
the catalytic synthesis of phytosterol esters in solvent-free systems.
Fortunately, a yield of 95.0% was achieved after optimizing the
reaction conditions, and a yield of 70.0% can still be maintained after
6 cycles.
A research on the determination of effective natural compounds for atherosclerosi
Authors: Gökalp Faik
Published: November 2023

Background and Purpose Atherosclerosis is a serious disease that starts
with a local lesion in the vessels and progressesto a heart attack. The
recent increase in heart attack disease and the increase i n deaths
related to it makes it important to discover drug candidate ligands to
be detected against the receptors determined in this disease. Methods
and Results In this study, chemical calculation method was used to
determine the interaction with Atherosclerosis receptors determined by
literature studies and the bonds to be formed at the molecular level and
the inhibition mechanism.The foods, spices and active ingredients in
various medicinal plants that we consume as daily food supplements were
identified as ligands at the end of the research conducted with the
literature review, and the inhibition effects on the receptors that
suppress the distribution of cholesterol, one of the biggest causes of
atherosclerosis, to the cells through the blood were determined by
comparing the currently used reference drugs. The data obtained from
here is important in terms of determining drug candidate active
substances in experimental and clinical studies to be conducted on
atherosclerosis, preventing time and substance loss and giving
direction.
Novel rod-like carbon nanomaterials as NIR-responsive drug delivery system for potential anticancer applications
Authors: Liu Mengru , Du Xiaoxue , Liu Jingyi , Wang Guangshuo , Yang Jiajia , Wang Xueling , Han Shuai , Huo Zhongchao
Published: November 2023

The combination of chemotherapy and photothermal therapy shows great
potential to achieve synergistic anti-tumor effect. However, it is still
a great challenge to design stimuli responsive drug release systems with
integrated photothermal/chemotherapy functions. In this paper, novel
rod-like carbon nanomaterials (RCNs) were prepared by soft template
hydrothermal method with glucose as raw materials, which were proved to
have good biocompatibility, excellent drug-loading capacity and high
photothermal efficiency. After that, RCNs we used to load doxorubicin
(DOX) for integrated photothermal/chemotherapy toward cancer, which
demonstrated good treatment efficiency under NIR irradiation. Our
approach provided a novel NIR-responsive nano platform for combined
photothermal/chemotherapy toward cancer, which was considered to be of
great potential in anticancer applications.
Immunoregulation as a protective factor of the nervous system in degenerative diseases
Authors: Figueroa Gloria Pérez , Gallegos-Altamirano Edwin , Ichikawa-Escamilla Eduardo , Guevara-Salinas Adrián , Adalid-Peralta Laura
Published: November 2023

Regulatory cells are critical for maintaining immune homeostasis in the
central nervous system. Regulatory cell populations have been reported
to control neuroinflammation in neurodegenerative conditions like
Parkinson’s disease, multiple sclerosis, myasthenia gravis,
encephalomyelitis, and Alzheimer’s disease by protecting neurons through
different mechanisms, including the production of cytokines such as
IL-10 and TGF-β, promoting the expression of inhibitory receptors (PD1,
TIM3, LAG3), and inducing tolerance through cell-cell interactions by
CTLA-4. Various phenotypes of CD4+ and CD8+ regulatory T cells, Bregs,
MDCS, and tolDCs have been described and, despite the great interest in
their function, few studies have focused on elucidating their role in
neurodegenerative diseases. Therefore, this review aims to describe the
mechanisms of regulation and suppression of effector cells in
neurodegenerative diseases. The study of these mechanisms has led to the
development of therapeutic approaches targeting molecules with
suppressive or regulatory activity in severe neurological disorders.
Realistic Modeling of Exposure to Sub-6 GHz Fifth-Generation Mobile Phone Radiation in Anatomical Child Head Model
Authors: Ramadan Ahmed S. , Shafey H. M. , Abdelshafe Nabil Y. , Abdelrahman Ali K.
Published: November 2023

The exposure of human children to smartphone radiation has been rapidly
increasing in the past few years because of the development of
smartphones and smartphone networks. Additionally, global crises, such
as COVID-19 lockdown, dramatically escalated electronic consumption of
each individual human. Due to the relatively small head size, different
anatomical structure, and different electromagnetic properties, a child
head is expected to react differently to exposure to electromagnetic
radiation compared to an adult head. This study presents a computational
analysis of Specific Absorption Rate (SAR) and temperature distributions
inside anatomical 7-year-old child head model exposed to sub-6 GHz
fifth-generation mobile phone radiation. Four different frequencies (0.9
GHz, 1.8 GHz, 3 GHz, and 6 GHz) as well as two antenna positions (voice
and video call) were investigated. Electromagnetic wave propagation
equations and thermal energy balance equation were numerically solved
inside the computational space with 1W antenna power. It is observed
that for 6 GHz frequency in voice call position, peak SAR and
temperature values of 22.5 W/kg and 8.14 °C, respectively, were
obtained. However, the peak SAR and temperature points locations were
not correlated. Also, peak temperature elevation surpassed 90% of its
ultimate value within the first 5 minutes of exposure time.
In-situ biological biogas upgrading using upflow anaerobic polyfoam bioreactor (UAPB): operational and biological aspects.
Authors: Sabbah Isam , Baransi-Karkaby Katie , Yanuka-Golub Keren , Hassanin Mahdi , Massalha Nedal
Published: November 2023

A high rate upflow anaerobic polyfoam-based bioreactor (UAPB) was
developed for lab-scale in-situ biogas upgrading. The use of a
porous diffuser, alongside high gas recirculation, led to a higher H
liquid mass transfer, and subsequently to a better
uptake for high CH content (up to 90%). Although our
attempts to optimize both operational parameters (H
flow rate and gas recirculation ratio) were not successful, at a very
high recirculation ratio (32) and flow rate (54 mL/h), a significant
improvement of the hydrogen consumption was achieved. These operational
conditions have in turn driven the methanogenic community towards the
dominance of Methanosaetaceae, which out-competed
Methanosarcinaceae. Nevertheless, a highly stable methane
production rate was observed despite the methanogenic turnover. During
the different applied operational conditions, the bacterial community
was especially impacted, resulting in substantial shifts of taxonomic
groups. Notably, Aeromonadaceae was the only bacterial group
positively correlated with increasing hydrogen consumption rates. The
capacity of Aeromonadaceae to extracellularly donate electrons
suggests that direct interspecies electron transfer (DIET) enhanced
biogas upgrading. Overall, the proposed innovative biological
in-situ biogas upgrading technology using the UAPB configuration
shows promising results for stable, simple and effective biological
biogas upgrading.
Effect of Intra-Build Design Parameters on the Fracture Toughness Properties of EBM Ti6Al4V
Authors: Mojib N. Melody , Fero Kaan , Atmadja Nicole , Arola Dwayne , Chen Xu , Ramulu M.
Published: November 2023

Metal Additive Manufacturing technologies provide new opportunities for
manufacturing complex components. However, the limited and scattered
data on damage tolerance behavior is hindering adoption in safe-critical
applications. A design of experiments (DOE) is used in this study to
provide an understanding of the Electron Beam Melted (EBM) Ti6Al4V
fracture toughness properties. Three builds comprised of 150 compact
tension samples were printed representative of the EBM build chamber,
followed by surface machining, microstructural characterization, X-ray
microcomputed tomography (µCT), and fracture toughness testing per ASTM
E399. Analysis of Variance (ANOVA) statistics on the influence and
interaction of intra-build design parameters on the As-Built and
Machined samples showed orientation, build location, and geometry to
contribute to property variation. EBM fracture toughness reported an
average of 65 MPa√m, with an increase in build height and proximity to
the center of the build envelope. The location- and size-dependent
properties resulted from changes in microstructure and porosity
throughout the build space. While intra-build design variation was
present, the EBM Ti6Al4V fracture toughness properties reported a 10%
overall variation comparable to wrought and cast alloys. The extensive
experimental work in this study shows EBM Ti6Al4V to be a repeatable and
reliable alloy for use in load-bearing applications.
Expression of RAG and rearrangement of the secondary genes of BCR in mature peripheral B lymphocytes in Takayasu arteritis
Authors: Luo Xiaoyun , Wang Zhenni , Jing Zongxu
Published: November 2023

Objective: To evalute the expression of RAG and BCR gene rearrangement
in mature peripheral B lymphocytes in Takayasu arteritis, reveal the
possible mechanism of humoral immune response in Takayasu arteritis.
Methods: Patients with Takayasu arteritis (10 cases) and healthy
volunteers with age and sex matching (10cases, as control group) from
Beijing Shijitan Hospital, Capital Medical University , and Peking Union
Medical College Hospital from 2022 to 2023 were included in this study.
The recombinant activating gene mRNA test uesd real-time quantitative
PCR (RT-PCR) . Western blot was used to detect the expression levels of
the RAG protein . The NGS gene sequencing technology was performed for
the B cell receptor (BCR) gene sequencing. Results: The expression level
of RAG1 mRNA and RAG2 mRNA in peripheral mature B lymphocytes in TA
patients was significantly higher than that of normal controls（RAG1
5.56±1.71 vs. 1.94±0.86, P＜0.05; RAG2 5.26±1.59 vs. 1.65±0.64,
P＜0.05）, respectively; The expression level of the RAG1 protein
and the RAG2 protein in peripheral mature B lymphocytes in TA patients
was significantly higher than that of normal controls（RAG1 4.33±1.58
vs. 1.52±0.59, P＜0.05; RAG2 4.67±1.88 vs. 1.59±0.56,
P＜0.05）, respectively. The number of peripheral B lymphocyte
BCR clonotypes in the group of patients with TA was significantly higher
than in the normal control group（1574±317.7 vs. 801.3±202.1,
P＜0.05）. The abundance of the BCR gene V region in TA patients
was higher than that in the normal control group（31.185% vs.
13.449%）.The abundance of genes in the BCR V region was positively
correlated with RAG1 and RAG2 (correlation coefficient r=1.00,
P<0.05), respectively. Conclusion: High expression of
the RAG gene in mature peripheral B lymphocytes may cause BCR secondary
gene rearrangement in mature peripheral B lymphocytes in patients with
Takayasu arteritis, suggesting that there is a possibility of secondary
gene rearrangement in TA and providing important clues for the potential
diagnostic indicator and therapeutic target of Takayasu arteritis, and
further exploration and analysis is required for larger samples.
Effects of p-coumaric acid on Probiotic Properties of Lactobacillus acidophilus LA-5 and Lacticaseibacillus rhamnosus GG
Authors: DEREBASİ Buse Nur , BULUT Sena DAVRAN , ERDEN Büşra AKSOY , SADEGHIAN Nastaran , TASLİMİ Parham , Celebioglu Ufuk
Published: November 2023

p-coumaric acid (p-CA) is one of the most abundant phenolic compounds in
nature and human diet. Probiotic bacteria are microorganisms conferring
health benefits on host when administered in adequate amounts. The
synbiotic interaction of these two contents, found in gastrointestinal
tract, and effect of this interaction on intestines are not known. Thus,
this study aimed to investigate synbiotic relationship between p-CA and
Lactobacillus acidophilus LA-5 (LA-5), Lacticaseibacillus
rhamnosus GG (LGG). They were grown in the presence of different
concentrations of p-CA and effects of p-CA on probiotic properties, as
well as in vitro effects on AChE and BChE activities were examined.
Results indicated p-CA did not negatively affect bacterial growth, but
increased auto-aggregation of both probiotics. While p-CA increased
co-aggregation of LA-5 and LGG against Escherichia coli, it decreased
co-aggregation against Staphylococcus aureus. Probiotics grown with p-CA
were more resistant to pepsin. While p-CA increased the resistance of
LA-5 to bile salt, it decreased the resistance of LGG. The combinations
of bacteria and p-CA efficiently suppressed AChE and BChE with
inhibition (%) 11.31-68.06 and 13.47-65.14, respectively. Furthermore,
surface analysis was conducted using FTIR to investigate the interaction
of p-coumaric acid with LA-5 and LGG, and changes in cell components on
the bacterial surface were analyzed. The results, recorded in range of
4000-600 cm⁻¹ with resolution of 4 cm⁻¹, demonstrated that p-CA
significantly affected only the phosphate/CH ratio for both bacteria.
These results indicate the addition of p-CA to the probiotic growth may
enhance the probiotic properties of bacteria.
Properties of the Nili Fossae Olivine-rich lithology: orbital and in situ at Séítah
Authors: Brown Adrian Jon , Kah Linda C , Mandon Lucia , Wiens Roger C. , Pinet Patrick C. , Clavé Elise , Mouelic Stephane Le , Udry Arya , Gasda Patrick J , Royer Clément , Hickman-Lewis Keyron , Cousin Agnès , Simon Justin I. , Comellas Jade , Cloutis Edward , Fouchet Thierry , Fairen Alberto , Connell Stephanie , Flannery David Timothy , Horgan Briony Heather Noelle , Mayhew Lisa , Treiman Allan H. , Núñez Jorge I. , Wogsland Brittan Valhalla , Benzerara Karim , Amundsen Hans E. F. , Hand Kevin Peter , Debaille Vinciane , Essunfeld Ari , Beck Pierre , Tosca Nicholas James , Madariaga Juan Manuel , Forni Olivier
Published: November 2023

We have studied the properties of the Nili Fossae olivine lithology from
orbital data and in situ by the Mars 2020 rover at the Séítah unit in
Jezero crater. We used the geochemistry collected by the rover’s
instruments to calculate the viscosity and relative flow distance of the
Séítah unit. Based on the low viscosity and distribution of the unit we
postulate a ponded lava flow origin for the olivine rich unit at Séítah.
We calculate an approximate depth for the cumulate layer of the lava
pond based on the viscosity of the unit and model of Worster et al.
(1993).

We show that the resolution of orbital data is inadequate to map the
phyllosilicate 2.38 μm band and demonstrate that it can be supplemented
by in situ data from Mars 2020 SuperCam Laser Induced Breakdown
Spectroscopy (LIBS) and reflectance observations to show that the low Al
phyllosilicate in the olivine cumulate in the Séítah formation is either
talc, serpentine, hectorite, Fe/Mg smectite, saponite or stevensite.

We discuss two intertwining aspects of the history of the lithology: 1)
the potential emplacement and properties of the cumulate layer within a
ponded lava flow, using previously published models of ponded lava flows
and lava lakes, and 2) the limited extent of post emplacement
alteration, including phyllosilicate and carbonate alteration.
The Effect of Enviromental Uncertainty and Tax Avoidance: The Role Managerial Ability
Authors: Purnomo Hanny , Eriandani Rizky
Published: November 2023

Taxes play an essential role in state funding. As something that is not profitable for the company, it usually encourages efforts to reduce taxes by doing a tax avoidance. This study aims to determine the effect of environmental uncertainty on tax avoidance and to determine the managerial ability to weaken the effect of environmental uncertainty on tax avoidance. Using SPSS, 458 samples used in this study are manufacturing companies listed on the Indonesia Stock Exchange in the period 2016 – 2020. The results of this study indicate that environmental uncertainty affects tax avoidance and managerial ability strengthens the effect of environmental uncertainty on tax avoidance. This result may be due to the large influence of environmental uncertainty in the company so that the risks obtained are difficult for managers to overcome.
Strengthening Sharia Accountability and Transparancy for the Optimization of Cash Waqf Linked Sukuk
Authors: Erny Arianty  , M. Luthfi Mahrus  , Miftahul Hadi  , Iin Indrawati
Published: November 2023

This research is motivated by the fact that the cash waqf linked Sukuk fund collection has not met expectations, where one of the causes is the low implementation of accountability and transparency. This study aims to analyze strategies to overcome problems and strengthen the implementation of sharia perspective accountability and transparency as an effort to optimize CWLS fundraising. The method used is the theme approach and Analytical Network Process (ANP). Data was collected through the FGD method and distributing questionnaires to several informants from BWI, nazir (waqf fund managers), Islamic Banks as LKS Collecting Cash Waqf Funds (LKSPWU), the government, and KNEKS. The results show that the main strategy in overcoming the problem is to increase the monitoring and supervision function of regulators and the government. The main strategy for strengthening accountability and transparency is competency development in related fields and setting rules for the types of information that must be conveyed to the public.
The Influence of Company Growth, Profitability, Leverage, Financial Condition, and Previous Years’ Audit Opinions on Going Concern Audit Opinion (Empirical Study of the Real Estate and Property Industry Listed on the Indonesian Stock Exchange for the 2019-2021 Period)
Authors: Cahyono Yuli Tri , Benny Tjahjono  , Mahameru Rosy Rochmatullah  , Kusuma Wijayanto
Published: November 2023

A going concern audit opinion is an audit opinion given on an entity’s financial statements when its conditions differ from the assumption of business continuity. This research, therefore, aims to ascertain the impact of company growth, profitability, leverage, financial condition, and previous years’ audit opinions on the going concern audit opinions. The data used is quantitative. The real estate and property industry classification companies listed on the Indonesia Stock Exchange (BEI) in the 2019-2021 period were the objects of the research. Purposive sampling was used for the sampling, and 126 companies were obtained. The logistic regression analysis was employed in the data analysis method. According to the study findings, while previous year audit opinions had an impact, company growth, profitability, leverage, and financial condition had no impact on going concern audit opinion.
Assessment of MRI Safety Awareness and Practice Standards in Bangladesh
Authors: Rahman Mustafizur , Talukdar Arif Hossain , Obayda Md. Abu , Muneem Muhtasim Aziz , Parvin Tanzila , Jalali Mustaque Ahmed , Muraduzzaman SM
Published: November 2023

Objectives: The objective of this study was to evaluate the current MRI safety knowledge, awareness and practice standards among MRI technologist in Bangladesh and to perceive if the identified safety principles related to MRI management are in line with international standards.
Materials and Methods: The study was carried out with consent option among MRI technologist in Bangladesh. A self-structured questionnaire was used to collect data through email, the questionnaire contained ten parts and 47 questions in all. MRI technologist voluntarily consented and filled out the questionnaire. The questions were to explore knowledge about MRI safety policy and accessories, patient screening, adverse reaction, Infection control, Device labeling, Equipment safety, signage and barriers, access and communication, and MRI safety during pregnancy generally. The collected data were analyzed with the help of Microsoft Excel.
Results: Regarding knowledge of MRI equipment, 34% of respondents were unaware of the symbols or signs used to denote the various zones in your MRI suit, and 27% were unaware of the negative effects of quenching magnets. About 45% of respondents, who were asked about emergency/safety accessories’ availability, answered that crash carts and MRI-compatible anesthetic equipment aren’t present in the department. In case of awareness of different zones of the MRI suite, which is crucial for an MRI unit, 46.08% of respondents were unaware in this issue. 50% of respondents do not believe that MRI has any harmful effect to people who are pregnant. This study revealed that many MRI facilities generally are not aware of departmental/equipment safety notices & obstacles.
Conclusion: The study showed that awareness about MRI safely and practice standards were not encouraging with many of the MRI technologists due to their insufficient knowledge. They need training along with other supporting staff connected to patient to enhance their knowledge in implementation of safety policy, patient screening tools and exposure of MRI during pregnancy.
Интеграция стартапов в области пространственных данных в деятельность государственных научных учреждений
Authors: Омаров Роман , Паниди Евгений , Валова Елизавета , Арчаков Денис
Published: November 2023

Статья посвящена анализу путей организации взаимодействия стартап-проектов с государственными научными учреждениями для проведения совместных исследований. В современной практике методологическая организация работы стартапов и академических учреждений напрямую неосуществима. Существуют только грантовые программы от научных фондов, в которых предусмотрена организация совместной деятельности академических и частных учреждений. Поэтому, необходима разработка дополнительных возможностей для интеграции стартапов в совместную деятельность к научным центрам. Как один из путей решения такой проблемы – в рамках грантовой программы от Фонда содействия инновациям создано общество с ограниченной ответственностью «РЕД-ГИС», готовое к организации совместных исследований в области картографии, геоинформатики, пространственных данных.