bluuebunny/crossref_metadata_2025 huggingface dataset:
Three-Dimensional Quantification of Collagen Microstructure During Tensile Mechanical Loading of Skin
Authors: Woessner Alan E. , Jones Jake D. , Witt Nathan J. , Sander Edward A. , Quinn Kyle P.
Published: March 2021

Skin is a heterogeneous tissue that can undergo substantial structural and functional changes with age, disease, or following injury. Understanding how these changes impact the mechanical properties of skin requires three-dimensional (3D) quantification of the tissue microstructure and its kinematics. The goal of this study was to quantify these structure-function relationships via second harmonic generation (SHG) microscopy of mouse skin under tensile mechanical loading. Tissue deformation at the macro- and micro-scale was quantified, and a substantial decrease in tissue volume and a large Poisson’s ratio was detected with stretch, indicating the skin differs substantially from the hyperelastic material models historically used to explain its behavior. Additionally, the relative amount of measured strain did not significantly change between length scales, suggesting that the collagen fiber network is uniformly distributing applied strains. Analysis of undeformed collagen fiber organization and volume fraction revealed a length scale dependency for both metrics. 3D analysis of SHG volumes also showed that collagen fiber alignment increased in the direction of stretch, but fiber volume fraction did not change. Interestingly, 3D fiber kinematics was found to have a non-affine relationship with tissue deformation, and an affine transformation of the micro-scale fiber network overestimates the amount of fiber realignment. This result, along with the other outcomes, highlights the importance of accurate, scale-matched 3D experimental measurements when developing multi-scale models of skin mechanical function.
OTUD5 Variants Associated With X-Linked Intellectual Disability and Congenital Malformation
Authors: Saida Ken , Fukuda Tokiko , Scott Daryl A. , Sengoku Toru , Ogata Kazuhiro , Nicosia Annarita , Hernandez-Garcia Andres , Lalani Seema R. , Azamian Mahshid S. , Streff Haley , Liu Pengfei , Dai Hongzheng , Mizuguchi Takeshi , Miyatake Satoko , Asahina Miki , Ogata Tsutomu , Miyake Noriko , Matsumoto Naomichi
Published: March 2021

Background

X-linked intellectual disability (XLID), which occurs predominantly in males, is a relatively common and genetically heterogeneous disorder in which over 100 mutated genes have been reported. The OTUD5 gene at Xp11.23 encodes ovarian tumor deubiquitinase 5 protein, which is a deubiquitinating enzyme member of the ovarian tumor family. LINKage-specific-deubiquitylation-deficiency-induced embryonic defects (LINKED) syndrome, arising from pathogenic OTUD5 variants, was recently reported as a new XLID with additional congenital anomalies.

Methods

We investigated three affected males (49- and 47-year-old brothers [Individuals 1 and 2] and a 2-year-old boy [Individual 3]) from two families who showed developmental delay. Their common clinical features included developmental delay, hypotonia, short stature, and distinctive facial features, such as telecanthus and a depressed nasal bridge. Individuals 1 and 2 showed epilepsy and brain magnetic resonance imaging showed a thin corpus callosum and mild ventriculomegaly. Individual 3 showed congenital malformations, including tetralogy of Fallot, hypospadias, and bilateral cryptorchidism. To identify the genetic cause of these features, we performed whole-exome sequencing.

Results

A hemizygous OTUD5 missense variant, c.878A>T, p.Asn293Ile [NM_017602.4], was identified in one family with Individuals 1 and 2, and another missense variant, c.1210 C>T, p.Arg404Trp, in the other family with Individual 3, respectively. The former variant has not been registered in public databases and was predicted to be pathogenic by multiple in silico prediction tools. The latter variant p.Arg404Trp was previously reported as a pathogenic OTUD5 variant, and Individual 3 showed a typical LINKED syndrome phenotype. However, Individuals 1 and 2, with the novel variant (p.Asn293Ile), showed no cardiac or genitourinary malformations.

Conclusions

Unlike previous reports of LINKED syndrome, which described early lethality with congenital cardiac anomalies, our three cases are still alive. Notably, the adult brothers with the novel missense OTUD5 variant have lived into their forties. This may be indicative of a milder phenotype as a possible genotype-phenotype correlation. These findings imply a possible long-term prognosis for individuals with this new XLID syndrome, and a wider phenotypic variation than initially thought.
Exploiting Phagocytic Checkpoints in Nanomedicine: Applications in Imaging and Combination Therapies
Authors: Landry Madeleine R. , Walker Joshua M. , Sun Conroy
Published: March 2021

Recent interest in cancer immunotherapy has largely been focused on the adaptive immune system, particularly adoptive T-cell therapy and immune checkpoint blockade (ICB). Despite improvements in overall survival and progression-free survival across multiple cancer types, neither cell-based therapies nor ICB results in durable disease control in the majority of patients. A critical component of antitumor immunity is the mononuclear phagocyte system and its role in both innate and adaptive immunity. The phagocytic functions of these cells have been shown to be modulated through multiple pathways, including the CD47-SIRPα axis, which is manipulated by cancer cells for immune evasion. In addition to CD47, tumors express a variety of other “don’t eat me” signals, including beta-2-microglobulin and CD24, and “eat me” signals, including calreticulin and phosphatidylserine. Therapies targeting these signals can lead to increased phagocytosis of cancer cells; however, because “don’t eat me” signals are markers of “self” on normal cells, treatment can result in negative off-target effects, such as anemia and B-cell depletion. Recent preclinical research has demonstrated the potential of nanocarriers to synergize with prophagocytic therapies, address the off-target effects, improve pharmacokinetics, and codeliver chemotherapeutics. The high surface area-to-volume ratio of nanoparticles paired with preferential size for passive targeting allows for greater accumulation of therapeutic cargo. In addition, nanomaterials hold promise as molecular imaging agents for the detection of phagocytic markers. This mini review highlights the unique capabilities of nanotechnology to expand the application and efficacy of immunotherapy through recently discovered phagocytotic checkpoint therapies.
Analysis of the Polypropylene-Based Aluminium-Air Battery
Authors: Tan Weng Cheong , Saw Lip Huat , Yew Ming Chian , Sun Dongyang , Cai Zuansi , Chong Wen Tong , Kuo Pei-Yu
Published: March 2021

Global energy demand is rising due to the rapid development and adoption of new technologies in every sector. Hence, there is a need to introduce a clean energy source that does not cause damage to the environment. Aluminium-air battery with its high theoretical specific volumetric capacity is an exciting alternative for post-lithium energy storage and has been at the forefront of energy research for years. However, the conventional aqueous electrolyte-based aluminium-air battery with bulky liquid storage, parasitic corrosion of aluminium in contact with the electrolyte, and formation of a passive oxide or hydroxide layer has precluded its widespread application. In order to achieve successful simplification and cost-effectiveness, a novel idea of a polypropylene-based aluminium-air battery is proposed. In this work, a polypropylene-based aluminium-air battery was constructed using aluminium foil as an anode, carbon fiber cloth as an air-cathode, and Polypropylene and Kimwipes as the separator. The effects of the electrolyte concentration on the aluminium-air battery were investigated and analyzed using various discharge currents. The study showed that the performance of the polypropylene separator is better than that of the Kimwipes separator. The battery capacity is negatively correlated with the concentrations of the electrolyte. At a discharge current of 30 mA, the aluminium-air battery has a specific capacity of 375 mAh g−1 when 1 M of potassium hydroxide was used as electrolyte.
To Trade or Not to Trade? Using Bayesian Belief Networks to Assess How to Manage Commercial Wildlife Trade in a Complex World
Authors: Bennett Elizabeth L. , Underwood Fiona M. , Milner-Gulland E.J.
Published: March 2021

International commercial trade in wildlife, whether legal or illegal, is one of the greatest threats to multiple species of wildlife today. Opinions on how to address it are deeply divided across the conservation community. Approaches fall into two broad categories: making the trade illegal to protect against any form of commercial trade or allowing some or all of the trade to be legal and seeking to manage it through sustainable trade. The conservation community is often deeply polarized on which is the better option. We posit that a way to choose between these options is by considering species-specific attributes of biological productivity, management context, and demand. We develop a conceptual framework to assess which option is more likely to result in successful conservation of a species. We show how to construct a Bayesian Belief Network (BBN) to model how these attributes (1) interact to affect the sustainability of the species’ population and (2) vary under different trade management regimes. This approach can support scientifically based decision-making, by predicting the likely sustainability outcome for a population of a species under different trade management regimes, given its particular characteristics and context. The BBN allows identification of key points at which conservation interventions could change the potential outcome. It also provides the opportunity to explore how different assumptions about how humans might respond to different trade regimes affects outcomes. We illustrate these ideas by using the BBN for a hypothetical terrestrial mammal species population and discuss how the BBN can be extended for species with different characteristics, for example, those that can be stockpiled or when there are multiple products. This approach has the potential to help the conservation community to assess the most appropriate regime for managing wildlife trade in a transparent, open, and scientifically based way.
The Application of Head-Up Tilt Test to Diagnose Hemodynamic Type of Orthostatic Intolerance in Children Aged Between 3 and 5 Years
Authors: Zou Runmei , Wang Shuo , Li Fang , Lin Ping , Zhang Juan , Wang Yuwen , Xu Yi , Wang Cheng
Published: March 2021

Objectives: The head-up tilt test (HUTT) is a useful tool to assess autonomic function and to reproduce neurally mediated reflex. In this study, we evaluated the use of HUTT in pediatric patients aged 3–5 years with orthostatic intolerance.

Materials and Methods: The medical history and HUTT records of 345 (180 males, aged from 3 to 5 years) cases of patients who complained of symptoms of orthostatic intolerance and who visited the Syncope Ward, Children's Medical Center, The Second Xiangya Hospital, Central South University from January 2003 to December 2019, were reviewed retrospectively.

Results: Seventy-nine (22.9%) cases had positive responses to complete HUTT (basic HUTT and sublingual nitroglycerin HUTT), while 29 (8.4%) cases had positive responses if only basic HUTT was performed. Sublingual nitroglycerin provocation significantly increased the positive rate of the test (x2= 27.565, P < 0.001). The most frequent hemodynamic response to HUTT was vasoinhibitory type vasovagal syncope (12.2%), Syncope (28.7%), and dizziness (22.6%) were the most common symptoms. Eight cases discontinued the test due to intolerable symptoms without severe adverse events occurring.

Conclusions: HUTT was safe and well-tolerated and could be used to diagnose the hemodynamic type of orthostatic intolerance in children aged 3–5 years.
EquiSim: An Open-Source Articulatable Statistical Model of the Equine Distal Limb
Authors: Van Houtte Jeroen , Vandenberghe Filip , Zheng Guoyan , Huysmans Toon , Sijbers Jan
Published: March 2021

Most digital models of the equine distal limb that are available in the community are static and/or subject specific; hence, they have limited applications in veterinary research. In this paper, we present an articulatable model of the entire equine distal limb based on statistical shape modeling. The model describes the inter-subject variability in bone geometry while maintaining proper jointspace distances to support model articulation toward different poses. Shape variation modes are explained in terms of common biometrics in order to ease model interpretation from a veterinary point of view. The model is publicly available through a graphical user interface (https://github.com/jvhoutte/equisim) in order to facilitate future digitalization in veterinary research, such as computer-aided designs, three-dimensional printing of bone implants, bone fracture risk assessment through finite element methods, and data registration and segmentation problems for clinical practices.
Usefulness of the Ranking Technique in the Microscopic Agglutination Test (MAT) to Predict the Most Likely Infecting Serogroup of Leptospira
Authors: Guedes Israel Barbosa , Souza Gisele Oliveira de , Castro Juliana Fernandes de Paula , Cavalini Matheus Burilli , de Souza Filho Antônio Francisco , Heinemann Marcos Bryan
Published: March 2021

The microscopic agglutination test (MAT) used for the serological diagnosis of leptospirosis, as a robust and inexpensive method, is still the reality in many laboratories worldwide. Both the performance and the interpretation of the MAT vary from region to region, making standardization difficult. The prediction of the probable infecting serogroup using this test is indispensable for elucidating the epidemiology of the disease; however, in veterinary medicine, many studies consider any reaction detected with a titer of 100, which may ultimately overestimate some serogroups. Thus, the aim of this study was to evaluate the usefulness of the ranking technique for predicting the probable infecting serogroup identified by the MAT, eliminating cross reactions with other serogroups. Leptospira strains (12 samples) were inoculated in hamsters, and after 30 days, serology was performed by the MAT for these animals to confirm the infecting serogroup. Using the ranking technique, the probable infectious serogroup found with the MAT was the same as that in which the strains of inoculated leptospires belonged; additionally, the technique can be applied in epidemiological studies involving herds.
Suitable CO2 Solubility Models for Determination of the CO2 Removal Performance of Oxygenators
Authors: Lukitsch Benjamin , Ecker Paul , Elenkov Martin , Janeczek Christoph , Jordan Christian , Krenn Claus G. , Ullrich Roman , Gfoehler Margit , Harasek Michael
Published: March 2021

CO2 removal via membrane oxygenators during lung protective ventilation has become a reliable clinical technique. For further optimization of oxygenators, accurate prediction of the CO2 removal rate is necessary. It can either be determined by measuring the CO2 content in the exhaust gas of the oxygenator (sweep flow-based) or using blood gas analyzer data and a CO2 solubility model (blood-based). In this study, we determined the CO2 removal rate of a prototype oxygenator utilizing both methods in in vitro trials with bovine and in vivo trials with porcine blood. While the sweep flow-based method is reliably accurate, the blood-based method depends on the accuracy of the solubility model. In this work, we quantified performances of four different solubility models by calculating the deviation of the CO2 removal rates determined by both methods. Obtained data suggest that the simplest model (Loeppky) performs better than the more complex ones (May, Siggaard-Anderson, and Zierenberg). The models of May, Siggaard-Anderson, and Zierenberg show a significantly better performance for in vitro bovine blood data than for in vivo porcine blood data. Furthermore, the suitability of the Loeppky model parameters for bovine blood (in vitro) and porcine blood (in vivo) is evaluated.
On a Discrete SEIR Epidemic Model with Exposed Infectivity, Feedback Vaccination and Partial Delayed Re-Susceptibility
Authors: De la Sen Manuel , Alonso-Quesada Santiago , Ibeas Asier
Published: March 2021

A new discrete Susceptible-Exposed-Infectious-Recovered (SEIR) epidemic model is proposed, and its properties of non-negativity and (both local and global) asymptotic stability of the solution sequence vector on the first orthant of the state-space are discussed. The calculation of the disease-free and the endemic equilibrium points is also performed. The model has the following main characteristics: (a) the exposed subpopulation is infective, as it is the infectious one, but their respective transmission rates may be distinct; (b) a feedback vaccination control law on the Susceptible is incorporated; and (c) the model is subject to delayed partial re-susceptibility in the sense that a partial immunity loss in the recovered individuals happens after a certain delay. In this way, a portion of formerly recovered individuals along a range of previous samples is incorporated again to the susceptible subpopulation. The rate of loss of partial immunity of the considered range of previous samples may be, in general, distinct for the various samples. It is found that the endemic equilibrium point is not reachable in the transmission rate range of values, which makes the disease-free one to be globally asymptotically stable. The critical transmission rate which confers to only one of the equilibrium points the property of being asymptotically stable (respectively below or beyond its value) is linked to the unity basic reproduction number and makes both equilibrium points to be coincident. In parallel, the endemic equilibrium point is reachable and globally asymptotically stable in the range for which the disease-free equilibrium point is unstable. It is also discussed the relevance of both the vaccination effort and the re-susceptibility level in the modification of the disease-free equilibrium point compared to its reached component values in their absence. The influences of the limit control gain and equilibrium re-susceptibility level in the reached endemic state are also explicitly made viewable for their interpretation from the endemic equilibrium components. Some simulation examples are tested and discussed by using disease parameterizations of COVID-19.
Gene Set Analysis Using Spatial Statistics
Authors: Riffo-Campos Angela L. , Ayala Guillermo , Montes Francisco
Published: March 2021

Gene differential expression consists of the study of the possible association between the gene expression, evaluated using different types of data as DNA microarray or RNA-Seq technologies, and the phenotype. This can be performed marginally for each gene (differential gene expression) or using a gene set collection (gene set analysis). A previous (marginal) per-gene analysis of differential expression is usually performed in order to obtain a set of significant genes or marginal p-values used later in the study of association between phenotype and gene expression. This paper proposes the use of methods of spatial statistics for testing gene set differential expression analysis using paired samples of RNA-Seq counts. This approach is not based on a previous per-gene differential expression analysis. Instead, we compare the paired counts within each sample/control using a binomial test. Each pair per gene will produce a p-value so gene expression profile is transformed into a vector of p-values which will be considered as an event belonging to a point pattern. This would be the first component of a bivariate point pattern. The second component is generated by applying two different randomization distributions to the correspondence between samples and treatment. The self-contained null hypothesis considered in gene set analysis can be formulated in terms of the associated point pattern as a random labeling of the considered bivariate point pattern. The gene sets were defined by the Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The proposed methodology was tested in four RNA-Seq datasets of colorectal cancer (CRC) patients and the results were contrasted with those obtained using the edgeR-GOseq pipeline. The proposed methodology has proved to be consistent at the biological and statistical level, in particular using Cuzick and Edwards test with one realization of the second component and between-pair distribution.
Local Convergence of the Continuous and Semi-Discrete Wavelet Transform in Lp(R)
Authors: Navarro-Fuentes Jaime , Arellano-Balderas Salvador , Herrera-Alcántara Oscar
Published: March 2021

The smoothness of functions f in the space Lp(R) with 1<p<∞ is studied through the local convergence of the continuous wavelet transform of f. Additionally, we study the smoothness of functions in Lp(R) by means of the local convergence of the semi-discrete wavelet transform.
Methylation of Cyanidin-3-O-Glucoside with Dimethyl Carbonate
Authors: Straßmann Sarah , Brehmer Tillman , Passon Maike , Schieber Andreas
Published: March 2021

The approach presented in this study is the first for the hemisynthesis of methylated anthocyanins. It was possible to obtain cyanidin-3-O-glucoside derivatives with different degrees of methylation. Cautious identification of 4′-, 5-, and 7-OH monomethylated derivatives was also accomplished. The methylation agent used was the “green chemical” dimethyl carbonate (DMC), which is characterized by low human and ecological toxicity. The influence of the temperature, reaction time, and amount of the required diazabicyclo[5.4.0]undec-7-en (DBU) catalyst on the formation of the products was examined. Compared to conventional synthesis methods for methylated flavonoids using DMC and DBU, the conditions identified in this study result in a reduction of reaction time, and an important side reaction, so-called carboxymethylation, was minimized by using higher amounts of catalyst.
Dynamic Contrast Enhanced-MR CEST Urography: An Emerging Tool in the Diagnosis and Management of Upper Urinary Tract Obstruction
Authors: Bo Shaowei , Sedaghat Farzad , Pavuluri KowsalyaDevi , Rowe Steven P. , Cohen Andrew , Kates Max , McMahon Michael T.
Published: March 2021

Upper urinary tract obstructions (UTOs) are blockages that inhibit the flow of urine through its normal course, leading to impaired kidney function. Imaging plays a significant role in the initial diagnosis of UTO, with anatomic imaging (primarily ultrasound (US) and non-contrast computed tomography (CT)) serving as screening tools for the detection of the dilation of the urinary collecting systems (i.e., hydronephrosis). Whether hydronephrosis represents UTO or a non-obstructive process is determined by functional imaging (typically nuclear medicine renal scintigraphy). If these exams reveal evidence of UTO but no discernable source, multiphase contrast enhanced CT urography and/or dynamic contrast enhanced MR urography (DCE-MRU) may be performed to delineate a cause. These are often performed in conjunction with direct ureteroscopic evaluation. While contrast-enhanced CT currently predominates, it can induce renal injury due to contrast induced nephropathy (CIN), subject patients to ionizing radiation and is limited in quantifying renal function (traditionally assessed by renal scintigraphy) and establishing the extent to which hydronephrosis is due to functional obstruction. Traditional MRI is similarly limited in its ability to quantify function. DCE-MRU presents concerns regarding nephrogenic systemic fibrosis (NSF), although decreased with newer gadolinium-based contrast agents, and regarding cumulative gadolinium deposition in the basal ganglia. DCE-MR CEST urography is a promising alternative, employing new MRI contrast agents and imaging schemes and allowing for concurrent assessment of renal anatomy and functional parameters. In this review we highlight clinical challenges in the diagnosis and management of UTO, identify key advances in imaging agents and techniques for DCE-MR CEST urography and provide perspective on how this technique may evolve in clinical importance.
Pengaruh Pendapatan Asli Daerah dan Dana Perimbangan Terhadap Belanja Modal Pemerintahan Daerah Kabupaten
Authors: Muttaqin Eky Ermal , Sari Warsani Purnama , Ritonga Pandapotan , Fadillah Dinda
Published: March 2021

This study aims to determine the effect of regional own-source revenue and balance funds on capital expenditure in Langkat District Government. This type of research is quantitative with an associative approach. The type of data used is secondary data in the form of APBD reports obtained from the Regional Financial Management Agency and Langkat District. Data collection techniques with documentation and observation with data analysis techniques using multiple linear regression. The results showed that partially local revenue variables had significant effect on capital expenditure and balancing funds had a significant and significant effect on capital expenditure in Langkat District and simultaneously regional original income and balance funds had a positive and significant effect on capital expenditure in Langkat District.
Yuridis Putusan Mahkamah Konstitusi Nomor 35/PUU-X/2012 Tentang Keberadaan Hutan Adat Masyarakat
Authors: Rachman Syaiful , Nawawi Mansyur , Umanailo M Chairul Basrun
Published: March 2021

In principle, forest and forestry management is a management process for all components of the ecosystem, including humans. Utilization of forests to facilitate economic growth has eliminated the interests of customary forest communities, the rights of indigenous peoples have been protected as human rights, as stated in Law Number 39 of 1999 concerning the basic provisions of human rights. The people of Buru District, Grandeng Village, have an area of forest area for other uses of around 600 hectares which can be used for the benefit of local communities, but there are often problems between the Transmigration Community and Indigenous People who have unresolved ownership of land areas based on customary law, as well as the involvement of the local government Buru Regency in providing solutions to problem-solving, the method used is descriptive qualitative with interview instruments and a review of legal documents related to the research theme. The results that can be conveyed are the utilization of Customary forest products and their management by the community in Lolongguba sub-district, often in coordination with Hinolong Baman or the Head of Soa, which means that legally the implementation of the Constitutional Court Decision, No.35 / PUU-X / 2012 concerning the Existence of Community Customary Forests has been implemented in the community, however, the institutionality of the Waeapo Plains Indigenous Peoples has not been maximized, both in the implementation of customary law norms, as a result of factors, human resources, economy, social and Indigenous institutions themselves. Based on legal research, it is necessary to formulate a legal umbrella both government regulations and regional regulations regarding ownership of forests and forest products.
Eksistensi Industri Anyaman Bambu Di Era Modernisasi Ditinjau Dari Segi Desain Dan Teknik Finishing Di Sanggar Kreatif “Bunga Matahari” Binjai
Authors: Santoso Safira , Mesra Mesra , Wiwaramulja Dwi Budi
Published: March 2021

This study aims to: determine the existence of woven bamboo, survival strategies, materials in the finishing process of woven bamboo products at Sunflower Studio. The population in this study were 200 pieces of woven bamboo in the Sunflower Studio. The samples used were 20 products from 10 types of products produced. The method used is descriptive qualitative method with data collection techniques through observation, interviews, and documentation. The results of this study indicate that the sunflower weaving business still exists because it is supported by maintaining the quality of materials and after-service to consumers. Sanggar Bunga Matahari can maintain a neat and symmetrical product design, so that consumers are interested in continuing to order their products. The finishing technique applied by the Sunflower Studio is H2O immersion, staining and followed by varnish.
Analisis Bentuk dan Proporsi Patung Monumen Veteran di Gedung Yudha Bhakti DPD Legiun Veteran Republik Indonesia di Kota Medan
Authors: Afini Afini , Mirwa Tetty
Published: March 2021

This study aims to find out the shape and proportion of monument statues of veterans in the building yudha bhakti DPD legion of veterans of the Republic of Indonesia in the city of Medan. The problem is focused on the shape and structure of the proportions of the sculpture that are less in accordance with anatomical theory. Data collection procedures are carried out through observations, interviews and documentation studies. The data is observed by deciphering and clarifying based on the anatomical form of the statue. The research method used in this research is descriptive qualitative research, because it is a research that seeks to break down, explain and describe all data obtained from research. The results showed that veteran monument statues still have shortcomings, both in terms of shape and proportion, but this does not reduce the implied meaning of the monument statues of veterans of the Republic of Indonesia in the city of Medan.
Síndrome de Takotsuobo o miocardiopatía por estrés. A propósito de un caso
Authors: Chacón Pedro Pablo
Published: March 2021

El Síndrome de Takotsubo también llamada miocardiopatía por estrés , síndrome de corazón roto o apical ballooning es un síndrome caracterizado por una disfunción sistólica regional transitoria, apical y una base hipercontráctil del ventrículo izquierdo. Fue descrita por primera vez en Japón en 1990 por Sato y col. su nombre se deriva de tako (pulpo) tsubo ( olla ) la cual era una trampa que utilizaban los pescadores para capturar pulpos en Japón, lo cual es una imagen similar a la apariencia sistólica del ventrículo izquierdo en la forma mas típica y común de esta patología. Las características clínicas son similares a las presentadas en el infarto agudo de miocardio , sin embargo en el estudio angiográfico no se encuentra evidencia de obstrucción arterial coronaria o ruptura de placa.

En esta ocasión se presenta el caso de una paciente femenina, posmenopáusica, con un cuadro agudo de dolor torácico tipo anginoso posterior a evento emocional estresante, con evidencia de elevación de enzimas cardiacas, EKG sin cambios de isquemia aguda,  en el cual se documenta  en la angiografía coronaria arterias coronarias normales y ventriculografia con datos característicos de Síndrome de Takotsubo.
Pranayama boost Immunity
Authors: S Maheswari
Published: March 2021

Every human on the is to develop knowledge in order to experience happiness satisfaction and peace. All living being draw life force from the comic naturally. Man exists by transforming the natural resources into things of use and comfort with the help of his skills and knowledge which is an art. Pranayama refers to the breathing techniques which cleans our Respiratory track and boost up the immune system. It is the dynamic bridge between body and mind. It brings the energy under the control and stabilise the flow of air into our body. Through which the body can observe the sufficient level of oxygen and improves the immune intelligence. This article discusses the importance and necessity of Pranayama practice in Ashtanga yoga for the human body and mind.
COMPUTER SIMULATION OF CASTING AND SOLIDIFICATION PROCESSES OF STANDARD CAST SAMPLES OF GREY CAST IRON
Authors: Baron A. A. , Palatkina L. V. , Palatkin S. V.
Published: March 2021

For standard tension samples of gray cast iron, the possibility of using computer modeling to study factors affecting the morphology of dendritic crystals and the volumetric arrangement of defects of shrinkage origin is shown.
EFEKTIVITAS BAKTERI ASAM LAKTAT NIRA LONTAR DALAM SILASE JERAMI PADI
Authors: Foeh Nancy , Detha Annytha , Ndaong Nemay , Datta Frans Umbu , Ludji Pau Putri
Published: March 2021

One of feed preservation method in the form of an airtight silo (anaerobic) is silage. The addition of Lactic Acid Bacteria in rice straw can increase the quality and quantity of silage products. The purpose of this research is to determine whether the lactic acid bacteria isolated from palm sap can be used as a starter in making silage and to determine the level of damage and pH of jermai silage up to day 14. The stages of this method  include: making probiotics, making silage with treatment: (P0: EM4; P1: BAL 50ml; P2: BAL 75ml; P3: BAL 100ml; P4: BAL 125ml; P5: BAL 150ml; P6: BAL 175ml). The results showed that lactic acid bacteria from palm sap can be used as a starter in rice straw, at P1 with the addition of 50 ml lactic acid bacteria showed better silage results when compared to other treatments, which was characterized by light brown silage quality ( golden yellow), soft texture, sour smell, 4.54% silage presentation damage and pH 5.
ANALISIS PERBANDINGAN ALGORITMA WARSHALL DAN DIJKSTRAA PADA METODE GVRP DALAM PENENTUAN RUTE TERPENDEK (STUDI KASUS : PT YAKULT CABANG SUMBAWA)
Authors: Hermanto Koko
Published: March 2021

Yakult is one of the large industrial companies engaged in the manufacturing sectorfermented milk. This company has business activities, namely selling anddistributing fermented milk to shops. The purpose of this research isanalyze the comparison between Warshall and Dijkstraa's Algorithm on the GVRP method indetermination of the shortest route. The General Vehicle Routing Problem (GVRP) methodused to make it easier to classify the many shops (vertek) intovarious groups (clusters) so as to determine the optimal route and costsminimal. The Warshall algorithm is a method that makes it easy to determinethe shortest route from all points to all points and has a simple method andeasy to implement. While Dijkstraa's algorithm is a method for searchingshortest path between 2 points from starting point to destination point. In this study analyzedthat the Warshall and Dijkstraa algorithms for determining the shortest route have a waycalculations and results that are almost the same as the difference between the total distance of 800 meters withdifference in cost of IDR 645 in one go. The different routes are only in cluster 6 andcluster 9. The conclusion of this study shows that both the Warshall Algorithm andDijkstraa's algorithm has a calculation method that is almost the same as the total distance andcosts have a relatively small difference.
The validation of an L2 English listening self-efficacy instrument using Rasch analysis
Authors: Shepherd Martin Eric
Published: March 2021

This paper details the development and validation of a listening self-efficacy instrument for EFL/ESL learners with beginner- to-intermediate-level English language proficiency. Self-efficacy, or the belief in one's ability to perform a task successfully, is believed to determine how likely individuals will be to cope with difficulties relating to the task domain (e.g., listening, speaking, reading, or writing), and to sustain their effort in spite of obstacles (Bandura, 1997). To date, few instruments have been developed to evaluate English L2 listening self-efficacy. The instrument presented here was distributed among a sample of first- and second-year Japanese university students (N = 121), and, unlike most previously developed questionnaires, was validated through the use of Rasch analysis. The results of the administration of the questionnaire showed that learners' responses differed predictably and considerably, thereby suggesting the utility of the instrument for future use by EFL/ESL practitioners.
Neurological Sequelae Following Pediatric Cardiac Interventions
Authors: Agha Hala , Hussien Mai Mahmoud , Girgis Marian Y , Afify Omneya Gamal Eldin , Haroun Mervat
Published: March 2021

AIM: The aim of the present study was to assess neurological sequelae within 30 days of surgical or cardiac catheter interventions in infants and children.
METHOD: In this cross-sectional study, we evaluated all patients who developed neurological problems after cardiac interventions either by surgery or by catheter by clinical evaluation, brain imaging, and electrophysiological studies.
RESULTS: Among 1200 procedures were performed; 895 (74.6%) were cardiac catheterizations either diagnostic or intervention, 167 (13.9%) were open-heart surgery, and 138 (11.5%) were closed heart surgery. The overall incidence of post-procedure neurological dysfunction in the studied population was 3.4%. The differences between the three groups were statistically significant (p < 0.0001(. In our series, the neurological complications were in the form of disturbed conscious level in 2/41 (4.9%), impaired motor function in 11/41 (26.8%), impaired mental functions in 6/41(14.6%), hyperreflexia in 27/41 (65.9%), and seizures in 38/41 (92.7%). The most common presentation of seizures was in the form of focal fits 21/41 (51.2%), followed by generalized fits in 15/41(36.6%) and then myoclonic fits 2/41 (4.9%).
CONCLUSION: Seizures are the most common complication following cardiac interventions in pediatric age and the highest percentage following open heart surgery.
Banditisme et contestation de l'ordre allogène au Nord-Cameroun
Authors: Saïbou Issa , Mangmadi Ngoyoum
Published: March 2021

Résumé L’histoire politique du bassin du lac Tchad regorge de figures dont l’audace a traversé le temps. Leur aura, transmise aux générations récentes à travers les traditions orales, particulièrement les chansons, retrace l’action d’hommes virils, intrépides, protecteurs de leur communauté. Dans l’adversité, leur mémoire est ressassée pour exalter les vertus de de l’endurance. violence perpétrés Ceci est à l’encontre l’endoperception, des adversaires un regard de valorisant la communauté. et approbateur Si, historiquement, des actes l’agression à main armée est un mode d’accumulation et une pratique culturelle, il n’en demeure pas moins qu’avec les mutations politiques de la région, l’imposition des hégémonies musulmanes sur les groupes dits païens et l’avènement de la colonisation européenne à la fin du xix e siècle, le pillage fut criminalisé. Du fait de son impact sur les ressources et la sécurité des personnes, le pillard est désormais qualifié de voleur. Cette appellation est non seulement péjorative, mais encore elle délégitime la fonction politique du vol en tant que mode de résistance. En confrontant la logique des communautés paysannes de la partie septentrionale du Cameroun et la logique des détenteurs de l’autorité traditionnelle et du pouvoir colonial, cet article étudie deux variantes du banditisme social, l’un communautaire, l’autre héroïque. Le caractère social du banditisme des Guiziga de la plaine du Diamaré résulte du recours au vol à main armée à l’encontre des Peuls, comme mode de résistance à leur hégémonie et de répulsion de leur domination. Le vol est alors une forme de guerre asymétrique face à des adversaires mieux équipés et alliés de l’administration coloniale. Au-delà de l’épopée proprement dite, l’exemple de Zigla rend compte de l’engagement d’un leader à défendre et à protéger son peuple aussi bien face aux pouvoirs musulmans locaux que face à l’autorité coloniale allemande. Certes, Zigla a fait carrière dans les razzias et les pillages, mais il n’était pas plus bandit que les chefs des royaumes et principautés musulmanes qui, eux aussi, organisaient des expéditions à l’encontre des Mousgoum et d’autres peuples pour collecter le butin. Cet article tente de réhabiliter la figure historique que fut Zigla, sans sublimer ses actes mais en les insérant dans les modes parallèles de résistance à l’influence étrangère.
L’ingénierie des PRU en Rhône-Alpes
Authors: Tauleigne Perrine
Published: March 2021

La rénovation urbaine a amené les collectivités locales à adapter leurs organisations et, souvent, à intégrer de nouvelles compétences. Le CR•DSU propose ici de faire un zoom sur l’ingénierie dédiée à la conduite des programmes de rénovation urbaine (PRU), à grands traits, en s’appuyant notamment sur une enquête conduite actuellement auprès des responsables de PRU de la région Rhône-Alpes 1 .
Pour un traitement prospectif des fragilités de mobilité : vers un droit à la mobilité
Authors: Montano Silvia Rosales
Published: March 2021

Silvia Rosales Montano, directrice d’études à l’agence d’urbanisme de l’agglomération lyonnaise, anciennement experte auprès de la DIV sur les enjeux de mobilité dans les quartiers de la politique de la ville, nous livre ici une synthèse des travaux qu’elle a menés sur la question sociale de la mobilité et suggère la création d’une aide personnalisée à la mobilité, comme mesure pour la concrétisation d’un droit à la mobilité effectif sur l’ensemble des territoires.
Ville de Bourg-en-Bresse : un diagnostic pour mieux agir
Authors: Le Borgne Emmanuelle
Published: March 2021

À Bourg-en-Bresse, les acteurs locaux ont été conviés par la ville, dans le cadre de l’Atelier santé ville (ASV), à participer à l’élaboration du diagnostic de l’état de santé des jeunes, en particulier ceux vivant dans les quartiers prioritaires. Emmanuelle Le Borgne, coordinatrice ASV, retrace le déroulement de la démarche dont l’ambition est l’émergence d’une action publique structurée en faveur de la santé des jeunes des quartiers.
Quand sport et citoyenneté font équipe
Authors: Clavel-Inzirillo Béatrice
Published: March 2021

En adoptant le point de vue du psychologue du développement, on peut considérer que la citoyenneté ne relève pas d’une volonté de la part du sujet mais plutôt de compétences qui se développent, nommées ici compétences citoyennes. Mais quelle est la nature de ces compétences ? Quelles sont les conditions favorisant leur émergence ? Et quels sont les freins ? Béatrice Clavel-Inzirillo, maître de conférence en psychologie du développement à l’université Lumière Lyon 2, décrit en quoi le sport peut aider à la construction de la citoyenneté.
Ouvrir le chantier au public pour fertiliser les espaces publics
Authors: Herbert Fanny
Published: March 2021

Un demi-siècle après l’écriture du livre manifeste d’Henri Lefebvre, Le Droit à la ville 1 , il y a encore un enjeu fort à réinterroger les formes de la planification urbaine et la place de la dimension sociale dans la construction d’un projet politique de l’urbain. C’est ce que nous décrit Fanny Herbert, de l’association Carton Plein, dont le désir est que les projets urbains ne se fassent pas sans leurs habitants et avec les forces en présence.
Les inégalités de genre aussi sur les terrains sportifs
Authors: Ottogalli-Mazzacavallo Cécile
Published: March 2021

La dernière enquête sur les pratiques physiques et sportives en France prouve que la population et notamment les femmes se déclarent massivement sportives. Pourtant, une analyse plus précise rend visible les écarts femmes-hommes tant sur les modalités de l’engagement que sur les formes de pratique investies. Et ce constat est encore plus marquant dès lors qu’il se porte sur les quartiers en politique de la ville. Cécile Ottogalli, maîtresse de conférences au laboratoire sur les vulnérabilités et l’innovation dans le sport (L-Vis) de l’UFR-STAPS de Lyon 1, nous montre que le chemin vers l’accès égalitaire des filles et femmes aux activités physiques et sportives est encore long et semé d’embûches.
Lab’Elles : les filles se font une place à Romans-sur-Isère
Authors: Chasson Loïc , Fromentin Marjorie
Published: March 2021

À l’issue d’un diagnostic révélant le peu de visibilité des jeunes filles au sein du quartier prioritaire de la Monnaie, la Sauvegarde 26 a souhaité créer un espace qui leur soit totalement dédié. Le Lab’Elles, ouvert en septembre 2015, est conçu comme une première étape pour les jeunes filles avant d’investir l’espace public librement. La non-mixité est totalement assumée car l’objectif in fine est bien l’émancipation des filles. Entretien avec Loïc Chasson, coordonnateur du Lab’Elles et de la prévention spécialisée à Romans-sur-Isère.
Attente(s) et incertitude(s), le terreau de « Prenez Racines ! »
Authors: Bouhaddou Marie-Kenza
Published: March 2021

L’attente et l’incertitude sont des termes habituellement connotés négativement. Mais dans le cadre d’un projet artistique participatif, ils deviennent des ingrédients indispensables à une inscription du projet dans le temps urbain, politique et social long. Marie-Kenza Bouhaddou, enseignante à l’ENSA de Montpellier, doctorante en urbanisme au CRH-Lavue à Paris-Nanterre et médiatrice culturelle à la MJC Laënnec-Mermoz, renverse les schémas de pensée pour se servir de ces notions comme instauratrices de respirations sociales, artistiques et politiques, notamment à travers cet espace-temps spécifique et complexe qu’est le chantier au cœur d’un projet artistique participatif.
Des professionnels de l’éducation plaident pour une véritable continuité éducative
Authors: Hurtig-Delattre Catherine
Published: March 2021

Pendant la période du premier confinement, huit professionnel.le.s de l’éducation de Saint-Étienne et du Chambon-Feugerolles (Loire) se rencontrent par téléphone pour échanger sur la situation inédite qu’ils et elles vivent. Responsable d’une association de pédagogie sociale, salariée d’une collectivité territoriale et d’un centre social, enseignants engagés dans le mouvement Icem-pédagogie Freinet 1 , ce qui les réunit dans ce groupe informel, c’est leur travail auprès de familles de quartiers prioritaires. Ils et elles ont la conviction que l’éducation est l’affaire de tous et que la « continuité pédagogique » n’a de sens que si elle est pensée en « continuité éducative ». Catherine Hurtig-Delattre, enseignante et formatrice, a participé à ces échanges et s’en fait l’écho.
Les élus locaux face à la crise sanitaire : « Notre priorité, maintenir le lien avec les habitants des quartiers prioritaires ! »
Authors: Fromentin Marjorie
Published: March 2021

Plongés dans une situation d’urgence, les élus locaux ont dû s’adapter et prendre des décisions rapides pour gérer, sur le terrain, les besoins des habitants et répondre aux problématiques de tous ordres soulevées par la crise sanitaire. Dans les villes populaires, les enjeux étaient d’autant plus prégnants que les inégalités ont été fortement accentuées. Gilles Leproust, secrétaire général de l’association des maires Ville et Banlieue de France, également maire d’Allonnes dans la Sarthe, revient sur la gestion locale de la crise sanitaire.
Méditation sur le Notre Père (suite)
Authors: de Foucauld Charles
Published: March 2021

À Rome, le 23 janvier 1897, le bienheureux Charles de Foucauld rédigea une paraphrase du Notre Père. Il se préparait à quitter la Trappe pour partir à Nazareth.
La manne et le pain du Ciel
Authors: Dumoulin Pierre
Published: March 2021

La typologie et l’intertextualité éclairent le sens que revêt la demande du pain dans le Notre Père. Poursuivant l’interprétation pluriséculaire du prodige de la manne, le Livre de la Sagesse particulièrement s’avère précieux pour situer les affinités de l’oraison dominicale et du discours sur le Pain de vie (Sagesse 16 & Jean 6).
La dynamique du Notre Père
Authors: Pottier Bernard
Published: March 2021

Selon Maxime le Confesseur, le Pater nous fait parcourir de haut en bas toute la Création, depuis la Trinité créatrice en passant par les anges vers l’homme déchu, jusqu’au Malin qui veut nous empêcher de rejoindre notre Créateur. Cette vision contemplative amorce une dynamique ascétique et mystique de retour vers le Père, à l’image du Verbe qui, dans son abaissement, nous montre le chemin de la douceur et de l’humilité. La capacité de pardonner est alors l’indice de notre remontée vers Dieu.