bluuebunny/crossref_metadata_2025 huggingface dataset:
GENGIVOPLASTIA ASSOCIADA A TÉCNICA MANUAL - UM RELATO DE CASO CLÍNICO
Authors:   Orientador: Saul Alfredo Antezana Vera, Marques Wellington , Lima Vanessa , Junior Ary , Lins Marcia , Lira Ricardo
Published: August 2024

Introduction: Manual gingivoplasty is a technique for correcting and modifying gingival tissue. It can be employed in cases of gingival overgrowth, sequelae of periodontitis, and complications with dental implants, sometimes requiring periodontal therapy support for the procedure's effectiveness. Objective: To reshape and correct the gingival contour solely through gingival tissue excision. Materials and Methods: A 23-year-old male patient, expressing a desire for gingivoplasty for aesthetic purposes. Anamnesis, extraoral, intraoral examinations, and periapical radiographs were performed, concluding that the patient was in a normosystemic state. Following the treatment plan, oral environment preparation was carried out. Subsequently, for the surgery, extraoral antisepsis and intraoral hygiene were performed. Next, 2% lidocaine anesthesia was administered, blocking the posterior superior alveolar nerve, anterior superior alveolar nerve, and infiltration. Smile line markings were then made in continuous "sites" to allow for single- motion gingival insertion and excision, followed by post-surgical guidance for the patient. Results: Gingivoplasty was performed using the manual technique for gingival correction and alignment. The results demonstrated the effectiveness of this surgical treatment, restoring the patient's desired smile aesthetics, achieving harmonization between the teeth, lips, and gingiva. Conclusion: After a precise diagnosis, we concluded that gingivoplasty surgery, combined with the manual technique and periodontal therapy, are fundamental bases. The preoperative phase is crucial to facilitate the intraoperative and postoperative phases, ensuring patient safety and surgeon efficacy. Considering that care involves both the professional and the patient, this process offers a satisfactory outcome, renewing the smile's aesthetics.
A EMPATIA EM ESTUDANTES DE MEDICINA EM UMA INSTITUIÇÃO DE ENSINO SUPERIOR QUE UTILIZA MÉTODOS ATIVOS PARA O APRENDIZADO
Authors: Silva Silvan , Carreira Luciana
Published: August 2024

This study aimed to analyze empathy among medical students at a college using active teaching methods and propose a pedagogical plan consistent with the National Curriculum Guidelines. This was a descriptive, cross-sectional study with quantitative and qualitative analysis using the Jefferson Scale of Physician Empathy – student version. The average age of the students was 23.14 years (± 4.7); 63.1% were female; 92.6% single; 88.6% without paid work; 89.9% had studied entirely in private schools. The scores were: global (85.6 ± 6.9), compassionate care (12.4 ± 4.3), putting oneself in the patient’s place (7.6 ± 3.0), and perspective-taking (65.6 ± 5.6). The results indicated the need for a pedagogical plan focused on socio-emotional skills, especially empathy. The students’ empathy remained constant throughout the course, without significant decrease, influenced by sociodemographic profiles and self-assessment.
ONLINE ACTIVISM AND STREET HARASSMENT: DIGITAL JUSTICE OR SHOUTING INTO THE ETHER?
Authors: Fileborn Dr Bianca
Published: August 2024

Street harassment is a common experience in the lives of women. Despite both anecdotal and research evidence confirming its prevalence and harm, it is rarely responded to by the criminal justice system. Activist websites, such as Hollaback, have emerged in recent years in response to this silence regarding street harassment. While the aim of these sites is to draw attention to women’s experiences and work towards achieving a legal response, this article considers the extent to which online activist sites could function as an informal justice mechanism for victims of street harassment.
THE DOHA MODEL OF ORGAN DONATION AND TRANSPLANTATION: THINKING BEYOND CITIZENSHIP
Authors: Martin Dr Dominique , Fadhil Dr Riadh A S
Published: August 2024

This paper reviews the policy and practice of organ donation and transplantation in Qatar since January 2011. Important features of the Doha Model are explored, including: (i) all legal residents of Qatar have an equal right to access deceased donor organs and transplantation regardless of their citizenship status; (ii) no prioritisation in organ allocation; (iii) a multilingual and multicultural education and promotional program about donation; (iv) financial incentives for donation are prohibited. The ethical framework of this policy is examined with reference to the national self-sufficiency paradigm. Preliminary evidence of the impact of the Model in engaging a diverse multinational population is reviewed. The Model may inform policy and practice in other countries, particularly those with non-citizen resident populations.
Investigating 7-Eleven: Who are the real bad guys?
Authors: Fraser Michael
Published: August 2024

The illegal wage scandal at 7-Eleven Australia made national headlines in 2015 where it was revealed that foreign workers were being underpaid and exploited. I spent three years investigating this misconduct and along the way accumulated a unique insight into those who carried out exploitative practices and those it affected. This personal narrative discusses the challenges faced by workers and how these challenges, fears and barriers were overcome. While workers often speak of being subjected to threatening behaviour, also explored is the experiences of current and former Franchisees, including the bullying, intimidation and racial discrimination delivered at the hands of Head Office. Why would otherwise good people go to great lengths to engage in exploitative practices and how did mass underpayment happen to tens of thousands of foreign workers for so long without it becoming public knowledge? These questions form the basis of this personal narrative.
From Memoir to Make Believe: Beyoncé’s Lemonade and the Fabrication Possibility
Authors: Rosewarne Lauren
Published: August 2024

Beyoncé’s Lemonade has been one of the most critically acclaimed but also critically autopsied albums in recent years. Over and over again those 13 tracks have been mined to expose an apparent treasure trove of secrets into the artist’s marriage. So ready were listeners to assume that Lemonade was a confession of treachery and anguish, that completely lost was the possibility that perhaps the album was just 45 minutes of folly. In this essay I speculate about why audiences were so willing to interpret Lemonade as memoir rather than make-believe. I propose reasons ranging from the power of I, the influence of social media, and the severe constraints imposed by gender. Lemonade is a fascinating illustration of how a range of social phenomena and distinctly gendered stereotypes have strongly manipulated how women’s art is perceived.
HUMAN INTELLIGENCE + ARTIFICIAL INTELLIGENCE = HUMAN POTENTIAL
Authors: Tuffley David
Published: August 2024

Artificial Intelligence in the 21st Century is a powerfully disruptive technology, one whose influence in society is growing exponentially and will continue to grow in the coming decades. It is a technology with the potential to bring great benefits, but also great harm. How then may we reap the benefits of AI while ensuring we are not harmed by it? How do we ensure the primacy of human dignity as technology accelerates headlong into the future? I assert that AI is neither good nor bad in and of itself. It is merely an extension of humanity and not a threatening external entity as presented in popular culture. Clearly it is the uses to which AI is put that determines its value. The potential abuses of AI, for example in rogue autonomous weapons, should not place unreasonable restraint on the development of AI when the potential benefits arguably outweigh the harm.
The Analysis Study of Diagnostic Performance and Accuracy of Panoramic Radiography to Screen Bone Mineral Density in Woman: A Comprehensive Systematic Review
Authors: Audhi Muhammad Riefki , Salsabila Safira
Published: August 2024

Background: Bone mineral density (BMD) is a crucial measure of bone health, providing essential information for assessing the risk of fractures and other bone-related conditions. Panoramic radiography, commonly used in dental practice, presents a potential alternative for BMD screening. This systematic to evaluate the effectiveness of panoramic radiography in detecting BMD based on literatures of the last 10 years Methods: The study adhered to PRISMA 2020 standards, examining English literature from 2014 to 2024. It excluded editorials, reviews from the same journal, and submissions without a DOI. PubMed, SagePub, SpringerLink, and Google Scholar were utilized as literature sources. Result: Initially retrieving 360 articles from online databases (PubMed, SagePub, SpringerLink and Google Scholar) eight relevant papers were selected after three rounds of screening for full-text analysis. Conclusion: Panoramic radiographs, including MI, MCI, and MCW, are valuable tools for screening bone mineral density (BMD) and detecting osteoporosis in women. Panoramic radiographs are effective in detecting osteoporosis, especially in postmenopausal women.
Kualitas Pelayanan Perijinan Bagi Usaha Menengah di Dinas Penanaman Modal Pelayanan Terpadu Satu Pintu Kab. Jember
Authors: Putra Yuan Okta , Supranoto Supranoto , Suryawati Dina
Published: August 2024

Abstrak
Kualitas pelayanan perizinan usaha menengah di Dinas Penanaman Modal Pelayanan Terpadu Satu Pintu Kabupaten Jember penting untuk membangun kepercayaan dan loyalitas pelanggan. Regulasi perizinan untuk usaha mikro, kecil, dan menengah (UMKM) kadang menghambat proses izin. Keluhan masyarakat terkait lambatnya dan kurangnya keramahan pelayanan ini sering muncul di media. Artikelini bertujuan menjelaskan kualitas pelayanan perizinan UMKM di dinas tersebut dengan pendekatan kuantitatif dan metode deskriptif. Dalam Artikelini, 50 responden terlibat melalui accidental sampling. Kualitas pelayanan dinilai menggunakan model E-Service Quality atau Servqual yang mencakup enam dimensi: efisiensi, ketersediaan sistem, pemenuhan, privasi, responsivitas, dan kompensasi. Hasilnya menunjukkan kesenjangan antara persepsi masyarakat dan harapan mereka terhadap pelayanan perizinan, dengan gap negatif -14,3. Ini menunjukkan bahwa kualitas pelayanan perizinan usaha menengah di Dinas Penanaman Modal Pelayanan Terpadu Satu Pintu Kabupaten Jember belum memenuhi harapan masyarakat dan masih terkategori sebagai pelayanan yang cukup.
Kata kunci: Kualitas Pelayanan, Perizinan, Usaha Menengah, E-Service Quality.
Maintenance and Asset Management Improvement Based on Resilience and Sustainability Classification Systems
Authors: Azevedo Alvaro , Couto Paula , Silva Joao , Salvado Filipa , Lima Rodrigo
Published: August 2024

A. Vale e Azevedo, P. Couto, M.J. Falcao Silva, F. Salvado, R. Lima Alvaro Vale e Azevedo, Filipa Salvado, M. Joao Falcao Silva, Paula Couto
Innovative UI/UX Analysis of Cooperative Apps through Design Thinking
Authors: Fanani Rizki Dwi , Wiguna I Komang Arya Ganda , Iskandar Adi Panca Saputra , Parwita Wayan Gede Suka
Published: August 2024

Radha Krisna Savings and Loan Cooperative operates as an entity affiliated with Krisna Holding Company, more commonly referred to as Krisna Oleh-oleh. Although Radha Krisna Savings and Loan Cooperative has been in operation since 2010, it did not begin utilising a desktop application as its information system until 2014. This application has since been employed to facilitate a variety of transaction processes. The issue at the Radha Krisna Savings and Loan Cooperative is that the utilised application has begun to fail to support user requirements for transactions, as certain menus, features, user interface, and user experience continue to fall short of user expectations. In light of this issue, it is imperative to conduct an analysis of the collaborative application and construct a prototype that satisfies the diverse requirements of users, serving as a benchmark for the improvement of forthcoming applications. Utilising the Design Thinking method, prototype development consists of the following phases: Emphasise, Define, Ideate, Prototype, and Test. Figma is the instrument utilised for prototyping. A User Experience Questionnaire (UEQ) is administered to a sample of eight managers from the Radha Krisna Savings and Loan Cooperative as part of the testing phase. Based on the Benchmark Data, the average value for the attractiveness scale is 2.01 (Excellent), the average value for clarity is 2.31 (Excellent), the average value for efficiency is 1.91 (Excellent), the average value for accuracy is 1.81 (Excellent), the average value for stimulation is 2.06 (Excellent), and the average value for novelty is 1.94 (Excellent).
Diabetes mellitus 2: Estratégias para o controle glicêmico em adultos
Authors: Rodrigues de Lima Freire Ellen Vitoria , Oliveira Véras Saul Felipe , De Brito Melo Victória , Pereira da Rocha Carina , Oliveira dos Santos Mayla Daiane , Cavalcante de Moura Anna Clara , Alencar de Melo Leandra Rafaela , Ramos Pimentel Santana Leonardo , Souza dos Santos Thayse , Ribeiro Morais Daniele Vitória
Published: August 2024

O controle glicêmico em adultos com diabetes tipo 2 é crucial para prevenir complicações e melhorar a qualidade de vida, utilizando estratégias de mudanças no estilo de vida, tecnologias avançadas e intervenções farmacológicas. Mudanças no estilo de vida, como dieta mediterrânea e exercícios regulares, são eficazes, mas enfrentam desafios de adesão, sendo o suporte contínuo essencial. Tecnologias como o monitoramento contínuo da glicose ajudam no ajuste do tratamento, apesar dos desafios de custo e acessibilidade. A farmacoterapia com medicamentos como metformina e inibidores da SGLT2 é fundamental, e a personalização do tratamento é vital para o sucesso.A metodologia foi uma revisão integrativa da literatura, coletando dados em julho de 2024 de bases como PubMed, LILACS, SciELO e Medline, utilizando descritores específicos. Os critérios de inclusão foram estudos primários gratuitos e completos publicados entre 2019 e 2024. Foram selecionados 12 estudos para avaliação qualitativa, resultando em cinco incluídos na revisão final.Os resultados mostraram que a terapia cognitivo-comportamental via aplicativos digitais é eficaz na redução dos níveis de HbA1c. Intervenções digitais para atividade física apresentaram resultados variados, indicando a necessidade de aprimoramento. Suplementos nutricionais e novas formulações de insulina mostraram-se promissores no controle glicêmico. Conclui-se que a combinação de diferentes estratégias de tratamento, adaptadas às necessidades individuais, é essencial para otimizar a saúde e a qualidade de vida dos pacientes com diabetes tipo 2.
Impacto da nutrição enteral em neonatos prematuros: uma revisão integrativa
Authors: Rodrigues de Lima Freire Ellen Vitoria , Pinheiro Borges Neta Beatriz , Peixoto Teixeira Anelice , Pereira da Rocha Carina , Amanda Sabrina da Silva Jinkings  , Sampaio Lima Rodrigues Breno , Dos Santos Freire Anderson , Serrão de Oliveira Elder Rennê , Amorim Araújo Jaine , Silva Pereira Luana , Ferreira da Silva Natália , Cavalcante de Moura Anna Clara , Ramos Pimentel Santana Leonardo , Souza dos Santos Thayse , Ferreira Nunes Mateus Augusto , Rita de Cássia Gomes Costa
Published: August 2024

A nutrição enteral precoce é crucialpara neonatos prematuros, promovendocrescimento e desenvolvimento, além de reduzir otempo de internação e melhorar os resultadosneonatais. Desafios incluem imaturidadegastrointestinal, instabilidade hemodinâmica evariação na tolerância alimentar entre osneonatos. Fatores maternos e perinatais, comobaixo IMC materno e complicações gestacionais,também influenciam esses desafios. Programas desaúde pública, como Rede Cegonha e MãeCoruja, têm reduzido a mortalidade neonatalevitável. Práticas de reanimação neonatal sãofundamentais para a nutrição enteral precoce. Estarevisão integrativa visa avaliar os impactos danutrição enteral precoce em neonatos prematuros,focando nos desfechos clínicos, crescimento,desenvolvimento e desafios na implementação emunidades neonatais brasileiras. A revisão utilizou ametodologia PICO e buscou artigos em Português,Inglês e Espanhol, disponíveis online, com dadosprimários, de 2014-2024, nas bases LILACS eMEDLINE. Foram analisados artigos sobre oimpacto da nutrição enteral precoce nocrescimento e desenvolvimento dos neonatos, eas orientações fornecidas às famílias. Foramencontrados 862 textos, dos quais 10 atenderamaos critérios de inclusão. Os estudos destacaram ainfluência da nutrição no crescimento neonatal, aimportância da idade gestacional e do pesoadequado, a velocidade de avanço da alimentaçãoe a importância do leite materno. A nutrição enteralprecoce é essencial para neonatos prematuros,promovendo crescimento saudável e reduzindocomplicações. Políticas de saúde e práticasclínicas devem priorizar a nutrição enteral precocepara melhorar prognósticos neonatais.
Optical needle constructed by conical-angle modulated circular Airy vortex beams
Authors: Lu Wan-Li ,   School of Materials Science and Physics, China University of Mining and Technology, Xuzhou 221116, China
Published: August 2024

An optical needle is a specialized spatial light field characterized by an extremely small transverse spot size, capable of breaking through the diffraction limit, and also prossessing a long focal depth in the longitudinal direction. Typically, optical needles are generated by tightly focusing a beam using a lens. In this work, the generation of optical needles is demonstrated by using circular Airy vortex beams (CAVBs) through adjusting the conical angle. The CAVBs have a uniform distribution of circular polarization, thus eliminating the need for radial polarization states. Our research indicates that under the conical angle modulation, CAVBs with a topological charge of –1 (left-handed circular polarization) and 1 (right-handed circular polarization) can form optical needles. These optical needles possess a minimal transverse spot size, enabling them to exceed the diffraction limit while maintaining a long depth of focus. Furthermore, the depth of focus of the optical needle is almost linearly related to the primary ring radius of the beam. Increasing the primary ring radius can effectively enhance the depth of focus. CAVBs with different topological charges generate distinct hollow light fields, unlike optical needles. This is because the longitudinal component of the light beam is significantly enhanced by adjusting the conical angle. Only CAVBs with the appropriate topological charge exhibit a longitudinal light field near the optical axis, leading to the formation of optical needles. In contrast, other charges result in a hollow longitudinal light field, creating different hollow light fields. These research findings could have significant applications in super-resolution imaging and optical micromanipulation.
The glycoprotein quality control factor Malectin promotes coronavirus replication and viral protein biogenesis
Authors: Davies Jonathan P , Plate Lars
Published: August 2024

Coronaviruses (CoV) rewire host protein homeostasis (proteostasis) networks through interactions between viral nonstructural proteins (nsps) and host factors to promote infection. With the emergence of SARS-CoV-2, it is imperative to characterize host interactors shared across nsp homologs. Using quantitative proteomics and functional genetic screening, we identify conserved proteostasis interactors of nsp2 and nsp4 that serve pro-viral roles during infection of murine hepatitis virus – a model betacoronavirus. We uncover a glycoprotein quality control factor, Malectin (MLEC), which significantly reduces infectious titers when knocked down. During infection, nsp2 interacts with MLEC-associated proteins and the MLEC-interactome is drastically altered, stabilizing association with the Oligosaccheryltransferase (OST) complex, a crucial component of viral glycoprotein production. MLEC promotes viral protein levels and genome replication through its quality control activity. Lastly, we show MLEC promotes SARS-CoV-2 replication. Our results reveal a role for MLEC in mediating CoV infection and identify a potential target for pan-CoV antivirals.
Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice
Authors: Araujo Alessandra M , Dekker Joseph D , Garrison Kendra , Su Zhe , Rhee Catherine , Hu Zicheng , Lee Bum-Kyu , Osorio Hurtado Daniel , Lee Jiwon , Iyer Vishwanath R , Ehrlich Lauren IR , Georgiou George , Ippolito Gregory C , Yi S Stephen , Tucker Haley O
Published: August 2024

We identified a novel mouse plasmacytoid dendritic cell (pDC) lineage derived from the common lymphoid progenitors (CLPs) that is dependent on expression of
Bcl11a
. These CLP-derived pDCs, which we refer to as “B-pDCs”, have a unique gene expression profile that includes hallmark B cell genes, normally not expressed in conventional pDCs. Despite expressing most classical pDC markers such as SIGLEC-H and PDCA1, B-pDCs lack IFN-α secretion, exhibiting a distinct inflammatory profile. Functionally, B-pDCs induce T cell proliferation more robustly than canonical pDCs following Toll-like receptor 9 (TLR9) engagement. B-pDCs, along with another homogeneous subpopulation of myeloid derived pDCs, display elevated levels of the cell-surface receptor tyrosine kinase AXL, mirroring human AXL
+
transitional DCs in function and transcriptional profile. Murine B-pDCs therefore represent a phenotypically and functionally distinct CLP-derived DC lineage specialized in T cell activation and previously not described in mice.
Super-enhancer-driven ZFP36L1 promotes PD-L1 expression in infiltrative gastric cancer
Authors: Wei Xujin , Liu Jie , Cheng Jia , Cai Wangyu , Xie Wen , Wang Kang , Lin Lingyun , Hou Jingjing , Cai Jianchun , Zhuo Huiqin
Published: August 2024

Gastric cancer (GC) is a major cause of cancer-related mortality worldwide. Despite the widespread recognition of tumor immunotherapy in treating unresectable GC, challenges, including ineffective immunotherapy and drug resistance, persist. Therefore, understanding the regulatory mechanisms of PD-L1, particularly in the context of super-enhancers (SEs) and zinc finger protein 36 ring finger protein-like 1 (ZFP36L1) RNA-binding protein, is crucial. In this study, we performed H3K27ac Cleavage Under Targets and Tagmentation (CUT&Tag) sequencing, investigated the heterogeneity of SEs between two GC subtypes with differential growth patterns, and revealed the immune escape signatures driven by ZFP36L1-SE in infiltrative GC through SEs inhibitors treatment. The regulation of ZFP36L1 to PD-L1 was evaluated by quantitative PCR, western blot, flow cytometry, and immunohistochemistry. Furthermore, we explored its regulatory mechanisms using a combination of molecular biology techniques, including luciferase reporter assay, GST/RNA pull-down, chromatin immunoprecipitation (ChIP)/RIP experiments, and in vivo functional assays. We demonstrated that ZFP36L1, driven by an SE, enhances IFN-γ-induced PD-L1 expression, with SPI1 identified as the specific transcription factor binding to ZFP36L1-SE. Mechanistically, ZFP36L1 binds to the adenylate uridylate-rich element in the 3ʹ untranslated region (3ʹUTR) of HDAC3 mRNA, exacerbating its mRNA decay, and thereby facilitating PD-L1 abnormal transcriptional activation. Collectively, our findings provide mechanistic insights into the role of the SPI1-ZFP36L1-HDAC3-PD-L1 signaling axis in orchestrating immune escape mechanisms in GC, thereby offering valuable insights into the potential targets for immune checkpoint therapy in GC management.
Super-enhancer-driven ZFP36L1 promotes PD-L1 expression in infiltrative gastric cancer
Authors: Wei Xujin , Liu Jie , Cheng Jia , Cai Wangyu , Xie Wen , Wang Kang , Lin Lingyun , Hou Jingjing , Zhuo Huiqin , Cai Jianchun
Published: August 2024

Gastric cancer (GC) is a major cause of cancer-related mortality worldwide. Despite the widespread recognition of tumor immunotherapy in treating unresectable GC, challenges, including ineffective immunotherapy and drug resistance, persist. Therefore, understanding the regulatory mechanisms of PD-L1, particularly in the context of super-enhancers (SEs) and zinc finger protein 36 ring finger protein-like 1 (ZFP36L1) RNA-binding protein, is crucial.
Å utvikle eit fagleg repertoar i kunst og handverk
Authors: Austbø Simonsen Elin , Fauske Laila Belinda
Published: August 2024

Denne artikkelen bygger på ei kasusstudie frå 5. trinn innan det norske grunnskulefaget kunst og handverk (KH). Undersøkinga søker større kunnskap om det faglege repertoaret av delte ressursar elevane i eit spesifikt praksisfellesskap øver inn og etablerer etter målsettinga om djupnelæring gjennom tre observerte oppgåveperiodar. Engelskspråkleg litteratur omtaler mellom anna djupnelæring som deep learning og in-dept learning. Data er henta frå deltakande observasjon, 12 individuelle elevintervju og dokument i form av oppgåvetekstar. Tematisk innhalds­analyse av visuell og skriftleg data viser at praksisfellesskapet først og fremst øver inn og etablerer eit ferdigheitsorientert handlingsrepertoar frå praktisk skapande arbeid med verktøy og materiale. Dette er i tråd med gjeldande læreplanverk og forbunde med premissa for praksisen. I lys av det faglege repertoaret som kjem til uttrykk i kasusstudien samt konseptet Knowledge Building kan ein seie at fellesskapet utviklar kunnskapsbasen sin. Det viser seg at elevane i liten grad omgrepsfestar sitt eige læringsutbytte, men at dei koplar læringa til ulike aspekt av det praktisk skapande arbeidet.
Nøkkelord: Kunst og handverk, Praksisfellesskap, Ferdigheitsorientert handlingsrepertoar, Djupnelæring, Knowledge Building
Image reconstruction in graphic design based on Global residual Network optimized compressed sensing model
Authors: Fu Xinxin , Tang Lujing , Bai Yingjie
Published: August 2024

The article aims to address the challenges of information degradation and distortion in graphic design, focusing on optimizing the traditional compressed sensing (CS) model. This optimization involves creating a co-reconstruction group derived from compressed observations of local image blocks. Following an initial reconstruction of compressed observations within similar groups, an initially reconstructed image block co-reconstruction group is obtained, featuring degraded reconstructed images. These images undergo channel stitching and are input into a global residual network. This network is composed of a non-local feature adaptive interaction module stacked with the aim of fusion to enhance local feature reconstruction. Results indicate that the solution space constraint for reconstructed images is achieved at a low sampling rate. Moreover, high-frequency information within the images is effectively reconstructed, improving image reconstruction accuracy.
Effect of Charcot Marie Tooth causing Mitofusin-2 mutations in the mitochondrial fusion and fission balance
Authors:   , Lagos Quiñones Daniel Alejandro
Published: August 2024

Las mitocondrias son organelos altamente dinámicos, mediado por procesos de fusión y fisión. Si bien se conocen los mecanismos moleculares que regulan casa proceso, se desconoce la maquinaria que media el equilibrio entre ellos. Las mutaciones en la proteína de fusión mitocondrial MFN2 se asocian al desarrollo Charcot Marie-Tooth 2A, una enfermedad neurodegenerativa de neuronas motoras. Estas mutantes de MFN2 alteran la morfología mitocondrial. Se desconoce si mutaciones de Mfn2 pueden afectar directamente la fisión mitocondrial. Nosotros evaluamos el efecto de mutantes de MFN2 que causan CMT2A en el equilibrio de fusión y fisión, y el metabolismo oxidativo. Estudiamos fibroblastos de piel derivados de individuos control y pacientes con CMT2A que portaban las mutantes MFN2-L248H o MFN2-M376V, además de fibroblastos embrionarios de ratón (MEF) WT que expresan de manera aguda o estable cada mutante. Evaluamos la morfología y los eventos de fusión y fisión mitocondrial mediante microscopía confocal en células vivas. Se estudiaron los niveles de proteínas de fusión y fisión, la tasa de consumo de oxígeno (OCR), la tasa de acidificación extracelular (ECAR) y subunidades de los complejos de la fosforilación oxidativa (OXPHOS). Los fibroblastos derivados de pacientes y células MEF WT que portan mutaciones L248H y M376V muestran una inhibición de la dinámica de fusión, asociado a alteración en los niveles de proteínas de fusión. Pero, MFN2-L248H determina una morfología mitocondrial hiperelongada opuesta a la fragmentación en las células que expresan MFN2-M376V. Consistentemente, MFN2-L248H indujo inhibición de la fisión, y aumento en pDrp1-Ser637 (anti-fisión). Las células que expresan MFN2-M376V muestran niveles aumentados de la forma pro-fisión de Drp1 (pSer616). Finalmente, las células MFN2-L248H muestran un aumento de OCR, pero caída en complejos de OXPHOS. M376V induce un aumento de ECAR, lo que sugiere un metabolismo más glicolítico. Por lo tanto, las mutaciones de MFN2 causantes de CMT2A alteran la dinámica de fisión mitocondrial, sumado a los defectos en fusión, que alteran en el metabolismo oxidativo de manera particular. Nuestro trabajo devela un nuevo mecanismo que puede contribuir a la fisiopatología de CMT2A.
En vías de civilización: la producción del niño-ciudadano global en las políticas educativas chilenas
Authors:   , Zamora Leyton María Paz
Published: August 2024

Una de las políticas educativas recientes sobre educación ciudadana en Chile es la Ley 20.911 “Plan de Formación Ciudadana” (PCF) que establece la obligatoriedad a las escuelas reconocidas por el Estado de incluir un plan de formación ciudadana dentro de sus planes de estudios. La siguiente investigación tiene como objetivo mapear la producción y legitimación de la noción de ciudadanía global en las políticas educativas chilenas contemporáneas, bajo el supuesto de que existe una producción universal de las infancias en base a valores y creencias del Norte Global. Desde una perspectiva nuevo-materialista y a través de una metodología basada en la teoría de los ensamblajes de Deleuze y Guattari, se analizaron documentos nacionales e internacionales sobre formación ciudadana en educación básica con el objetivo de rastrear las fuerzas materiales y discursivas que estarían operando en la producción del niño-ciudadano global en las políticas educativas chilenas. Los resultados evidencian una producción normativa y legitimada de niño-ciudadano global por medio de lógicas coloniales, discursos sobre el progreso, el respeto a la diversidad, la representación del riesgo y la intervención. De esta manera, se imagina un niño-ciudadano chileno/a como un sujeto en vías de civilización y, por tanto, como un riesgo para el desarrollo del sistema social, político y económico de las naciones.
UNA INTERVENCIÓN DESDE LA MULTIMODALIDAD Y LA PEDAGOGÍA DE LOS GÉNEROS DISCURSIVOS: PROPUESTA DIDÁCTICA PARA LA MEJORA DE LOS NIVELES DE COMPRENSIÓN LECTORA EN PRUEBAS ESTANDARIZADAS
Authors:   , Rodríguez González Catalina
Published: August 2024

La comprensión lectora es un tema relevante y contingente para abordar en educación, sobre todo luego de los resultados obtenidos en pruebas internacionales como PISA y nacionales como PAES. El bajo desempeño de los y las estudiantes chilenas en esta área es una preocupación que no deja indiferente a nadie. Desde esta problemática, se plantea una propuesta para mejorar las habilidades de comprensión lectora utilizando como recurso la multimodalidad, área que ha aumentado su auge estos últimos años, en especial en su vínculo con la educación, debido a que permite procesos de alfabetización exitosos. Para realizar esta investigación, se utilizó un instrumento que recopila preguntas de evaluaciones estandarizadas, PAES y PISA, donde se trabajan textos discontinuos y multimodales. Luego de la aplicación de este instrumento, se realizó una intervención desde la pedagogía de los géneros discursivos, utilizando textos multimodales y analizando la metafunción ideacional. Posterior a la intervención, se aplicó nuevamente el instrumento para contrastar resultados y saber cómo afectó el trabajo con la multimodalidad en el aula y en el desarrollo de las competencias lectoras.
Hydromechanical behavior of filtered copper tailing under static and cyclic loading in unsaturated condition
Authors:   , Gallardo Sepúlveda Ricardo Ignacio
Published: August 2024

Se considera que los depósitos de relaves filtrados tienen una estabilidad mecánica superior que otras alternativas, porque funcionan en estado no saturado. Sin embargo, en las últimas dos décadas, dado el incremento en las alturas alcanzadas y su uso en países sísmicos como Chile, se requiere avanzar en la comprensión de su comportamiento hidromecánico ante carga monótonas como cíclicas. Este trabajo pretende contribuir a la comprensión del comportamiento de este tipo de relaves mediante; (i) el estudio de el de los efectos de la auto-compactación por preso propio sobre la rigidez y la resistencia al corte a través de ensayos de laboratorio no saturados, (ii) el análisis del efecto de las tasas de deposición sobre la estabilidad global y los incrementos de saturación a través de modelación en elementos finitos y (iii) la evaluación del incremento de la presión de agua y aire en los poros y sus efectos sobre una potencial falla de flujo o propensión a la licuación. Los resultados muestran que (i) el efecto de la succión ante cargas drenadas genera incrementos de la resistencia al corte y de la rigidez hasta el 600%, sin embargo, tiende a desaparecer a medida que aumenta el confinamiento, alcanzando hasta el 95% de grado de saturación, (ii) la potencial generación de una superficie de falla en depósitos simulados computacionalmente ocurre cuando el suelo alcanza un grado de saturación del orden del 65% al 70% y es independiente de las tasas de deposición, la inclinación del talud y la altura de la pila y (iii) la succión matricial bajo carga monótona y cíclica para una condición no drenada disminuye durante la fase de corte y por lo tanto progresivamente se va generando una transición hacia la condición totalmente saturada. Por otro lado, la relación de resistencia cíclica (CSR) aumenta hasta el 57.8%, sin embargo, la probeta pierde continuidad cuando se alcanza una deformación volumétrica superior al 2.5%.
Enhancing English Writing Skills among Native Spanish-Speaking Students through translanguaging: an Action Research at Liceo 7, Santiago, Chile
Authors:   , Segovia Navarro Carla Lucia
Published: August 2024

Este proyecto de investigación-acción explora la enseñanza de la escritura en inglés mediante la actividad de translanguaging "Reading as Writers, Using Mentor Texts." Realizado en una clase de undécimo grado del Bachillerato Internacional en el Liceo 7 de Providencia, Santiago, Chile, el estudio tuvo como objetivo mejorar el rendimiento en la escritura de reseñas de películas (movie reviews). Para ello, se utilizó estratégicamente el español y el inglés, junto con la pedagogía basada en géneros (genre-based pedagogy), para enseñar las etapas específicas de la escritura de reseñas de películas y ampliar el repertorio lingüístico de los estudiantes.Los resultados obtenidos muestran que las actividades de translanguaging, junto con la pedagogía basada en géneros, mejoraron significativamente la capacidad de los estudiantes para escribir reseñas de películas. Además, estas intervenciones facilitaron la aplicación de nuevo vocabulario y estructuras lingüísticas complejas, enriqueciendo así su expresión escrita en inglés.
Experiencias asociadas al estigma del trastorno límite de personalidad en personas diagnosticadas con este diagnóstico
Authors:   , Velásquez Rivas Tania
Published: August 2024

El estigma impacta generando aumento de los síntomas, problemas en la adherencia al tratamiento, desesperanza y peor calidad de vida (Klein et al., 2022; Thornicroft et al., 2022). Uno de los trastornos de personalidad más estigmatizados dentro del sistema de salud es el Trastorno límite de la personalidad (TLP) (Day et al., 2018; Kulkarni, 2017).Las investigaciones de estigma en TLP se han centrado en el estigma estructural en los sistemas de salud, siendo asociado a la falta de servicios y a los discursos estigmatizantes de profesionales (Baker & Beazley, 2022; Black et al., 2011; Day et al., 2018; Klein et al., 2022a; Sheehan et al., 2016), por otro lado, se han enfocado en aspectos del autoestigma asociados a que las personas con TLP experimentan a menudo culpa y se sienten una carga para su entorno (Koivisto et al., 2022; Moltu et al, 2023), siendo escasos los estudios que consideran el estigma público y aún más escasos los que consideran en el análisis las experiencias de las personas que experimentan TLP. La presente investigación tiene por objetivo explorar y describir las experiencias de estigma que han vivido las personas diagnosticadas con TLP en Chile, para ello se entrevistaron 20 personas diagnosticadas con TLP y se realizó el análisis desde la teoría fundamentada (Strauss & Corbin, 2002). Se obtuvo como resultados que el estigma estructural se expresa en un mal tratamiento de parte de profesionales y experiencias de maltrato, así como una falta de cobertura, lo cual, deriva en que los profesionales realizan otros diagnósticos para garantizar la cobertura en salud. Respecto al estigma público, los participantes plantean que los medios de comunicación entregan una visión negativa del TLP, así como viven reacciones negativas de su entorno y experiencias de discriminación y exclusión social que son vividas transversalmente. En relación al autoestigma, existe generalmente una vivencia desfavorable en relación a tener TLP.
Attribution Style as Correlates of Secondary School Students’ Academic Achievement in Biology in Onitsha Education Zone
Authors: Okoli Josephine Nwanneka , Ezenwata Gladys Anulika
Published: August 2024

Aims: The study attribution style as correlates of secondary school students’ academic achievement in Biology in Onitsha Education Zone.
Study Design: The research adopted the correlation survey design.
Place and Duration of Study: Multi-stage sampling procedure was used to select a sample size of 720 students from 12 co-educational schools from a population of 4241 SS II students in 26 public secondary schools in Onitsha Education Zone.
Methodology: Multi-stage sampling procedure was used to select a sample size of 720 students from 12 co-educational schools from a population of 4241 SS II students in 26 public secondary schools in Onitsha Education Zone. The instruments for data collection were an adapted Attribution Style Scale (ASS) and Students Academic Achievement Scores in Biology. These instruments were administered using the direct delivery approach with the help of 12 regular teachers as research assistants from the sampled schools. Research questions 1 and 2 was answered using Pearson Product Moment Correlation Coefficient (r), data relating to the hypotheses 1 and 2 was analyzed using multiple regression analysis.
Results: The findings of the study revealed that a very low negative relationship exists between attribution style and secondary school students’ academic achievement in Biology (r = -0.05). A very low positive relationship exists between attribution style and male secondary school students’ academic achievement in Biology (r = 0.11). In the same vein, a very low negative relationship exists between attribution style and female secondary school students’ academic achievement in Biology (r = -0.09). There was no significant relationship between attribution style and male and female secondary school students’ academic achievement in Biology (r = 0.11/-0.09, t=0.21/-1.34, Pvalue=0.83/0.81), This study also revealed that the relationship existing between attribution style and secondary school students’ academic achievement in Biology is significant. On the contrary, there was no significant relationship between attribution style and male and female secondary school students’ academic achievement in Biology (r=-0.05, t=-1.1, Pvalue= 0.02).
Conclusion: A very low negative relationship between attribution style and secondary school students’ academic achievement in Biology, while a very low positive relationship between attribution style and male secondary school students’ academic achievement in Biology.
An Assessment of the Role of Economic Empowerment Schemes on Poverty Reduction among Youth and Women Groups: A Case of the Arusha Region, Tanzania
Authors: Mambosho Peter S. , Chole Grermanus S. , Kironyi Lekumok
Published: August 2024

Globally, the Women and Youth Development Fund provided via women's groups, has contributed a significant role in ensuring women’s and youth's economic empowerment. In Tanzania, the increase in population growth has brought both opportunities and challenges. One of the major challenges of population growth is the increase in unemployment and poverty among youth and women. To redress the situation, the Women, Youth, and People with Disabilities Revolving Fund (WYDF) was established at LGAs to ease lending challenges to the poor who are deprived of loan access from conventional financial institutions. The study assessed the role of economic empowerment schemes in reducing poverty among youth and women groups in, Arusha Region, Tanzania. Specifically, the study determined the influence of the provision of start-up capital, financial literacy training, and business capacity building on Poverty reduction among youth and women groups. The study adopted a survey research design based on a quantitative approach. Data was collected from 95 respondents from the Arusha region, Tanzania using questionnaires. The sample was selected using purposive sampling methods. Descriptive statistics was used to analyze the data using SPSS. Furthermore, inferential analysis was conducted whereby regression analysis was used to show the relationship between variables that influence poverty reduction among youth and women groups supported through economic empowerment schemes. The study found that the provision of start-up capital, financial literacy training, and business capacity building has a statistically significant influence on poverty reduction among youth and women groups. The study recommends that financial literacy should be provided to help entrepreneurs save sufficient money to provide adequate capital to invest in their businesses. The Government through youth and women empowerment programs should continuously offer training to youths and women groups especially those with no technical skills, on new production, proper allocation of funds, and marketing strategies/ techniques that aim at increasing the quality and quantity of harvest to achieve lasting impacts.
Climate Justice or Climate Injustice on the Planet Earth: Social, Geopolitical, Legal, Security, Visual, and Moral Dimensions
Authors: Hadžić Faruk
Published: August 2024

This study presents a comprehensive and insightful exploration of climate justice and climate injustice and their social, geopolitical, legal, security, visual and moral dimensions. It contributes perspectives on the global climate crisis and its implications. Theoretically and practically, the paper adds insight into global climate and environmental processes, concepts of climate justice and injustice, environmental and human security, climate visuals, and legal and moral approaches to the observed topics. The study explores contemporary academic scientific literature's methodological trends and critical themes. Besides a meta-analysis, content analysis, thematic analysis, a descriptive method, and an in-depth literature review of various scientific and expert-based data forms, the study incorporated the representation and analysis of visual expressions of climate change consequences and injustice. It also included human-centric aspects and perceptions of youth climate activists. Accordingly, the paper analyzes the essence and goals of climate justice, the consequences of climate injustice, and the positions of wealthy and poorer countries - mainly and severely affected by climate change, and offers normative solutions. Climate injustice processes and occurrences generate social injustice, inequalities, inequities, and exclusions while jeopardizing critical human security.
Integrated Nutrient Management for Optimum Growth Traits and Yield of Soybean Crop (Glycine max L. Merr.)
Authors: Gavit Shivaji Keshav , Gawate Avinash Nilkantha , Suryavanshi V. P. , Ambore Shweta Avinash , Prajapati Shailendra Sagar
Published: August 2024

A field experiment was conducted during kharif season of 2019 at the Experimental Farm, Department of Agronomy College of Agriculture, Latur to study “Integrated Nutrient Management in Soybean (Glycine max L.)”. The objective of experiment was to find out the effect of different organic and inorganic fertilizers on growth and yield of soybean. The experiment was laid out in a randomized block design with nine treatments and replicated thrice. The treatments were T1 – 100 % RDF, T2 – 100 % RDF + FYM @ 5 t ha-1, T3 – 75 % RDF + FYM @ 5 t ha-1, T4 – 100 % RDF + FYM @ 2.5 t ha-1, T5 – 75 % RDF + FYM @ 2.5 t ha-1, T6 – 100 % RDF + Vermicompost @ 2.5 t ha-1, T7 – 75 % RDF + Vermicompost @ 2.5 t ha-1, T8 – 100 % RDF + FYM @ 5 t ha-1 + Vermicompost @ 1.25 t ha-1, T9 – 75 % RDF + FYM @ 5 t ha-1 + Vermicompost @ 1.25 t ha-1. The result revealed that the application of Application of 100 % RDF + FYM at 5 t ha-1 + Vermicompost at 1.25 t ha-1 (T8) was recorded higher values of all the growth parameters of soybean viz., plant height (42.87 cm), number of functional leaves (31.53), dry matter accumulation (24.17 g), leaf area (2.67 dm2), leaf area index (2.77 %), number of branches plant-1 (6.20), Absolute Growth Rate (AGR) for plant height (0.04 cm day-1 plant-1), Absolute Growth Rate (AGR) for dry matter (-0.55 cm day-1 plant-1) and Relative Growth Rate (RGR) for dry matter (-0.019 g g-1 day-1).
A Study on Physico-Chemical and Nutritional Properties of Paras Variety Jamun (Syzygium cumini L.) Leaves
Authors: J.P. Rathod, , N. Seth, , Balas P. R. , G.P. Tagalpallewar, , R. Gandhi, , N.R. Sardar,
Published: August 2024

This study concentrated on the complete physico-chemical characterisation of paras variety fresh Jamun (Syzygium cumini L.) leaves, which are a rich resource in traditional medicinal and culinary uses. Physical parameters such as dimensions (length, width, thickness), mass, bulk density and colour (L*, a*, b*) were measured, yielding dimensions ranging from 151.61 to 174.10 mm in length, 67.20 to 97.57 mm in width, and 0.28 to 0.33 mm in thickness. These leaves had a greenish to dark green colour with mean L*, a* and b* values of 30.26 ± 5.94, -5.45 ± 3.02, and 9.21 ± 5.02, respectively. The chemical examination showed moisture content (59.56 ± 1.61 %, d.b.), ash content (1.96 ± 0.03 %), crude fibre (7.96 ± 0.28%), crude fat (0.58 ± 0.08 %), protein (5.48 ± 0.08 %), and carbohydrates (28.52 ± 1.59 %). The leaves have high total phenolic content (37.48 ± 2.57 mg / 100 g) and antioxidant activity (5.87 ± 0.17 %). These results highlight the nutritional and therapeutic potential of jamun leaves, hence endorsing their use in a range of health-promoting applications.