bluuebunny/crossref_metadata_2025 huggingface dataset:
Necessary and sufficient conditions for exact closures of epidemic equations on configuration model networks
Authors: Kiss István Z. , Kenah Eben , Rempała Grzegorz A.
Published: August 2023

We prove that it is possible to obtain the exact closure of SIR pairwise epidemic equations on a configuration model network if and only if the degree distribution follows a Poisson, binomial, or negative binomial distribution. The proof relies on establishing the equivalence, for these specific degree distributions, between the closed pairwise model and a dynamical survival analysis (DSA) model that was previously shown to be exact. Specifically, we demonstrate that the DSA model is equivalent to the well-known edge-based Volz model. Using this result, we also provide reductions of the closed pairwise and Volz models to a single equation that involves only susceptibles. This equation has a useful statistical interpretation in terms of times to infection. We provide some numerical examples to illustrate our results.
High-speed volumetric particle tracking measurements of unstable helical vortex pairs
Authors: Schröder Dominic , Leweke Thomas , Stumpf Eike
Published: August 2023

We present results from an experimental study investigating pairs of helical vortices generated by a one-bladed rotor in hovering conditions. Time-resolved volumetric Lagrangian particle tracking measurements are conducted in a water tunnel to analyze the three-dimensional development of the vortex system. The vortex pairs are generated by a specific tip design, which allows splitting the single tip vortex into two vortices, whose characteristics depend on the geometric fin parameters. The objective of this procedure is the modification of the tip vortex structure, in order to minimize negative effects caused by fluid–structure interactions in applications involving rotors. Certain vortex configurations are affected by centrifugal instabilities, which result in an immediate pronounced growth of the vortex cores. As a consequence of the instability, secondary vortex structures are formed between the unstable cores. The presence of these structures results in an accelerated break-up of the cores, causing them to merge. In order to investigate the influence of the trailing vorticity layer shed from the inner part of the blade, two blade designs with different radial circulation distributions are considered. The measurements are able to track the evolution of the vorticity layer and the secondary structures, providing new insights into the instability of closely spaced vortex pairs with varying circulation ratios.
Application of prolonged submental perforator flap to repair the postoperative defect of upper airway malignancy
Authors: Ma Hongzhi , Zhong Qi , Hou Lizhen , Feng Ling , He Shizhi , Lian Meng , Zhao Yanming , Wang Ru , Fang Jugao
Published: August 2023

Objectives

To explore the feasibility of making a submental perforator flap distal to the connecting line between the mastoid and the sternoclavicular joint under the guidance of neck-enhanced CT and repairing the postoperative defect of upper airway malignancy.

Materials and methods

This study retrospectively analysed 19 cases of upper airway malignant tumours treated in our department from January 2021 to September 2022, including 17 males and 2 females, aged 43–70 years.

Site of lesions

15 cases were in the laryngopharynx, 2 cases in the nasal cavity and paranasal sinus and 2 cases on the soft palate. All the lesions were malignant and at stages T2–4N0–2M0.

Surgical method

The extended submental perforator flap (size 22–15 × 6–7 cm) was prefabricated distal to the connecting line between the mastoid and the sternoclavicular joint. After tumour resection, the flap was used to repair the postoperative defect. Fifteen cases of laryngopharyngeal malignant tumours were repaired using the extended submental perforator flap with the vascular pedicle located on the opposite side of the tumour body. Two cases of nasal cavity and paranasal sinus tumours were repaired using the extended submental perforator flap combined with the temporalis muscle flap. The soft palate was completely removed in two patients with soft palate cancer and repaired using the folded extended submental perforator flap.

Results

Before the surgery, the reflux vein was observed by neck-enhanced CT, including 12 cases returning to the internal jugular vein and 7 cases to the external jugular vein. All 19 cases in which flaps were used survived, and 1 case had a postoperative infection. All the patients had nasal feeding removed after surgery. The tracheal cannula was removed from the patients with laryngeal preservation, and the pronunciation was satisfactory. Among them, patients with soft palate cancer repair had mild nasal reflux symptoms with smooth breathing. During the follow-up period of 4–24 months, 18 patients had no tumour recurrence or metastasis, and 1 patient had cervical lymph node metastasis.

Conclusions

This study highlights the use of a submental perforator flap distal to the connecting line between the mastoid and the sternoclavicular joint to repair postoperative defects for upper airway malignancy as an innovative surgical approach that provides more tissue and good arteriovenous blood supply to adjacent sites. This method has high clinical value and provides an effective option for repairing postoperative defects of upper airway malignancy.
Effects of prenatal alcohol exposition on cognitive outcomes in childhood and youth: a longitudinal analysis based on meconium ethyl glucuronide
Authors: Roetner Jakob , Van Doren Jessica , Maschke Janina , Kulke Louisa , Pontones Constanza , Fasching Peter A. , Beckmann Matthias W. , Lenz Bernd , Kratz Oliver , Moll Gunther H. , Kornhuber Johannes , Eichler Anna ,   und das IMAC-Mind-Consortium
Published: August 2023

Background

Prenatal alcohol exposure (PAE) has been linked to severe, adverse child outcomes. However, little is known regarding subclinical outcomes of low/moderate PAE and its longitudinal consequences, especially regarding neurophysiological and neurocognitive development. A newborn biomarker of PAE, meconium ethyl glucuronide (EtG), has been shown to predict cognitive impairments in primary-school-aged children. The current study investigated the ongoing effects of subclinical PAE in adolescence.

Methods

A sample of n = 96 mother–child dyads of the FRAMES/FRANCES cohort were classified into PAE/no PAE using EtG with a 10 ng/g cutoff. Mothers were recruited during pregnancy and children were assessed during primary-school age (M = 7.57, SD = 0.65, range: 6.00–9.92 years) and adolescence (M = 13.26, SD = 0.31, range: 12.79–14.20 years) on three levels: clinical (ADHD rating), neuropsychological (IQ score and performance in a go/nogo task), and neurophysiological (analysis of P3 event-related potentials (ERP) during said go/nogo task). Developmental outcomes and courses following PAE were assessed using rmANCOVAs, controlling for relevant confounders (socioeconomic status (SES), birth weight, and maternal psychopathology).

Results

Neurophysiological impairments emerged for exposed children in the form of diminished attentional resource recruiting in childhood and adolescence (reduced go-P3 amplitudes) with no differences in performance. Neuropsychological testing showed a reduced IQ score for both time points with dose-dependent effects in childhood. Clinical ADHD symptoms were not significantly affected.

Conclusion

Subclinical PAE, as determined by meconium EtG, has negative developmental consequences on cognitive function that persist from childhood to adolescence. These findings suggest that there is no safe limit for alcohol consumption during pregnancy and that more thorough screening of alcohol consumption during pregnancy is necessary for early identification and treatment of at-risk children.
A deep learning approach to investigate the filtration bleb functionality after glaucoma surgery: a preliminary study
Authors: Mastropasqua Leonardo , Agnifili Luca , Brescia Lorenza , Figus Michele , Posarelli Chiara , Oddone Francesco , Giammaria Sara , Sacchi Matteo , Pavan Marco , Innocenti Dante Degli , Olivotto Valentina , Sensi Stefano L , Mastropasqua Rodolfo
Published: August 2023

Purpose

To distinguish functioning from failed filtration blebs (FBs) implementing a deep learning (DL) model on slit-lamp images.

Methods

Retrospective, cross-sectional, multicenter study for development and validation of an artificial intelligence classification algorithm. The dataset consisted of 119 post-trabeculectomy FB images of whom we were aware of the surgical outcome. The ground truth labels were annotated and images splitted into three outcome classes: complete (C) or qualified success (Q), and failure (F). Images were prepared implementing various data cleaning and data transformations techniques. A set of DL models were trained using different ResNet architectures as the backbone. Transfer and ensemble learning were then applied to obtain a final combined model. Accuracy, sensitivity, specificity, area under the ROC curve, and area under the precision-recall curve were calculated to evaluate the final model. Kappa coefficient and P value on the accuracy measure were used to prove the statistical significance level.

Results

The DL approach reached good results in unraveling FB functionality. Overall, the model accuracy reached a score of 74%, with a sensitivity of 74% and a specificity of 87%. The area under the ROC curve was 0.8, whereas the area under the precision-recall curve was 0.74. The P value was equal to 0.00307, and the Kappa coefficient was 0.58.

Conclusions

All considered metrics supported that the final DL model was able to discriminate functioning from failed FBs, with good accuracy. This approach could support clinicians in the patients’ management after glaucoma surgery in absence of adjunctive clinical data.
Technical variability of cornea parameters derived from anterior segment OCT fitted with Fringe Zernike polynomials
Authors: Langenbucher Achim , Szentmáry Nóra , Cayless Alan , Wendelstein Jascha , Hoffmann Peter
Published: August 2023

Background

This study uses bootstrapping to evaluate the technical variability (in terms of model parameter variation) of Zernike corneal surface fit parameters based on Casia2 biometric data.

Methods

Using a dataset containing N = 6953 Casia2 biometric measurements from a cataractous population, a Fringe Zernike polynomial surface of radial degree 10 (36 components) was fitted to the height data. The fit error (height – reconstruction) was bootstrapped 100 times after normalisation. After reversal of normalisation, the bootstrapped fit errors were added to the reconstructed height, and characteristic surface parameters (flat/steep axis, radii, and asphericities in both axes) extracted. The median parameters refer to a robust surface representation for later estimates of elevation, whereas the SD of the 100 bootstraps refers to the variability of the surface fit.

Results

Bootstrapping gave median radius and asphericity values of 7.74/7.68 mm and −0.20/−0.24 for the corneal front surface in the flat/steep meridian and 6.52/6.37 mm and −0.22/−0.31 for the corneal back surface. The respective SD values for the 100 bootstraps were 0.0032/0.0028 mm and 0.0093/0.0082 for the front and 0.0126/0.0115 mm and 0.0366/0.0312 for the back surface. The uncertainties for the back surface are systematically larger as compared to the uncertainties of the front surface.

Conclusion

As measured with the Casia2 tomographer, the fit parameters for the corneal back surface exhibit a larger degree of variability compared with those for the front surface. Further studies are needed to show whether these uncertainties are representative for the situation where actual repeat measurements are possible.
Electrophysiological insights into deep brain stimulation of the network disorder dystonia
Authors: Franz Denise , Richter Angelika , Köhling Rüdiger
Published: August 2023

Deep brain stimulation (DBS), a treatment for modulating the abnormal central neuronal circuitry, has become the standard of care nowadays and is sometimes the only option to reduce symptoms of movement disorders such as dystonia. However, on the one hand, there are still open questions regarding the pathomechanisms of dystonia and, on the other hand, the mechanisms of DBS on neuronal circuitry. That lack of knowledge limits the therapeutic effect and makes it hard to predict the outcome of DBS for individual dystonia patients. Finding electrophysiological biomarkers seems to be a promising option to enable adapted individualised DBS treatment. However, biomarker search studies cannot be conducted on patients on a large scale and experimental approaches with animal models of dystonia are needed. In this review, physiological findings of deep brain stimulation studies in humans and animal models of dystonia are summarised and the current pathophysiological concepts of dystonia are discussed.
The spectrum of nodular lymphocyte predominant Hodgkin lymphoma: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology
Authors: Hartmann Sylvia , Dojcinov Stefan , Dotlic Snjezana , Gibson Sarah E. , Hsi Eric D. , Klapper Wolfram , Klimkowska Monika , Pinilla Socorro Maria Rodriguez , Richter Julia , Sabattini Elena , Tousseyn Thomas , de Jong Daphne
Published: August 2023

Session 4 of the 2021 European Association of Haematopathology/Society for Hematopathology Workshop focused on nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). First, the spectrum of immunophenotypic variations in NLPHL and the defining criteria for classic Hodgkin Lymphoma (CHL) were discussed. The added value of further immunophenotypic characterization of both tumor cells and microenvironment to support the differential diagnosis was presented. Next, unusual cases with combined growth patterns and evolution of morphological features over time were presented to explore the clinicopathological impact of presumed high-risk patterns. Based on a large collection of cases, the defining morphological, immunophenotypical, and gene expression features of T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) and THRLBCL-like NLPHL (pattern E) were reviewed to explore this challenging differential diagnosis and critically evaluate whether aggressive behavior and transformation of NLPHL can be predicted in practice.
Art authentication with vision transformers
Authors: Schaerf Ludovica , Postma Eric , Popovici Carina
Published: August 2023

In recent years, transformers, initially developed for language, have been successfully applied to visual tasks. Vision transformers have been shown to push the state of the art in a wide range of tasks, including image classification, object detection, and semantic segmentation. While ample research has shown promising results in art attribution and art authentication tasks using convolutional neural networks, this paper examines whether the superiority of vision transformers extends to art authentication, improving, thus, the reliability of computer-based authentication of artworks. Using a carefully compiled dataset of authentic paintings by Vincent van Gogh and two contrast datasets, we compare the art authentication performances of Swin transformers with those of EfficientNet. Using a standard contrast set containing imitations and proxies (works by painters with styles closely related to van Gogh), we find that EfficientNet achieves the best performance overall. With a contrast set that only consists of imitations, we find the Swin transformer to be superior to EfficientNet by achieving an authentication accuracy of over 85%. These results lead us to conclude that vision transformers represent a strong and promising contender in art authentication, particularly in enhancing the computer-based ability to detect artistic imitations.
Scoliosis in children with severe cerebral palsy: a population-based study of 206 children at GMFCS levels III–V
Authors: Vinje Svend , Terjesen Terje , Kibsgård Thomas
Published: August 2023

Purpose

To evaluate the prevalence of scoliosis and the rate of scoliosis progression in children with severe cerebral palsy (CP) at GMFCS levels III–V.

Methods

Two hundred and six children (86 girls, 120 boys), born 2002–2008, were recruited from The Norwegian Quality and Surveillance Registry for Cerebral Palsy (NorCP). Inclusion criteria were bilateral CP and GMFCS levels III–V. Scoliosis was evaluated annually by examination of the spine by a physiotherapist. Radiographic examination was performed in children with moderate or severe scoliosis at clinical evaluation. The Cobb angle was used as a measure of curve magnitude.

Results

Scoliosis, defined as Cobb angle ≥ 10°, occurred in 121 children (59%). Severe scoliosis (Cobb angle ≥ 40°) developed in 80 of the 206 patients (39%) at a mean age of 10.9 years (range 5–16) and was more prevalent in children at GMFCS level V (62%) than at levels IV (19%) and III (6%). Initial Cobb angle, Cobb angle ≥ 30° at age 10 years, and GMFCS level V were independent risk factors for severe scoliosis. In children at GMFCS level V, the rate of scoliosis progression decreased with age from a mean of 9.7° per year at age 3–5 years to 2–3° per year in children ≥ 11 years.

Conclusions

The prevalence of scoliosis among children with CP increased with decreasing motor functional level. The most important risk factors for progression of scoliosis were high initial Cobb angle, Cobb angle ≥ 30° at age 10 years, and GMFCS level V.
Nuclear translocation of beta catenin in patients with Rathke cleft cysts—clinical and imaging characteristics and risk of recurrence
Authors: Schmutzer Michael , Thorsteinsdottir Jun , Weller Jonathan , Rachinger Walter , Schichor Christian , Thon Niklas , Ueberschaer Moritz
Published: August 2023

Purpose

Although Rathke cleft cysts (RCC) are benign lesions of the sellar region, recurrence is frequent after surgical treatment. Nuclear translocation of ß-catenin (NTßC), a key effector of the wnt-signaling pathway that is responsible for cell renewal, has been shown to act as a proto-oncogene and is considered to be a potential risk factor for increased recurrence in RCC. In this study, we analyzed a surgically treated cohort into patients with and without NTßC expression in order to identify clinical and imaging differences and further evaluate the risk of recurrence.

Methods

Patients with resection of RCC between 04/2001 and 11/2020 were included. Histological specimens were immunohistochemically stained for ß-catenin. Study endpoints were time to cyst recurrence (TTR) and functional outcome. Functional outcome included ophthalmological and endocrinological data. Furthermore, MRI data were assessed.

Results

Seventy-three patients (median age 42.3 years) with RCC underwent mainly transsphenoidal cyst resection (95.9%), 4.1% via transcranial approach. Immunohistochemical staining for ß-catenin was feasible in 61/73 (83.6%) patients, with nuclear translocation detected in 13/61 cases (21.3%). Patients with and without NTßC were equally likely to present with endocrine dysfunction before surgery (p = 0.49). Postoperative new hypopituitarism occurred in 14/73 (19.2%) patients. Preoperative visual impairment was equal in both groups (p = 0.52). Vision improved in 8/21 (33.3%) patients and visual field deficits in 22/34 (64.7%) after surgery. There was no difference in visual and perimetric outcome between patients with and without NTßC (p = 0.45 and p = 0.23, respectively). On preoperative MRI, cyst volume (9.9 vs. 8.2 cm3; p = 0.4) and evidence of hemorrhage (30.8% vs. 35.4%; p = 0.99) were equal and postoperative cyst volume decreased significantly in both groups (0.7 vs. 0.5 cm3; p < 0.0001 each). Cyst progression occurred in 13/73 (17.8%) patients after 39.3 ± 60.3 months. Cyst drainage with partial removal of the cyst wall resulted in improved recurrence-free survival without increasing the risk of complications compared with cyst fenestration alone. Patients with postoperative diabetes insipidus had an increased risk for recurrence according to multivariate analysis (p = 0.005). NTßC was evident in 4/15 patients (26.7%) and was not associated with a higher risk for recurrence (p = 0.67).

Conclusion

Transnasal transsphenoidal cyst drainage with partial removal of the cyst wall reduces the risk of recurrence without increasing the risk of complications compared with fenestration of the cyst alone. Patients with postoperative diabetes insipidus seem to have an increased risk for recurrence. In contrast, NTßC was not associated with a higher risk of recurrence and did not provide stratification for clinically distinct patients.
Radiochemotherapie des Zervixkarzinoms
Authors: Sturdza Alina , Knoth Johannes
Published: August 2023

Hintergrund

Das lokal fortgeschrittene Zervixkarzinom ist eine schwerwiegende Erkrankung, bei der eine interdisziplinäre Behandlung das Optimum darstellt. Die Behandlung besteht gemäß der gemeinsamen Leitlinie der europäischen Gesellschaften für gynäkologische Onkologie, Strahlentherapie und Pathologie ab dem Stadium cT1b2/T2a2 N0 bzw. bei Vorliegen von Lymphknotenmetastasen aus einer primären Radiochemotherapie. Die Diagnostik erfolgt durch klinische Untersuchung, Biopsie und Bildgebung. Das Staging erfolgt nach FIGO (Fédération Internationale de Gynécologie et dʼObstétrique) und TNM.

Methodik

Im vorliegenden Artikel wird der aktuelle Stand der Wissenschaft anhand der einschlägigen Literatur mit besonderem Fokus auf den Ergebnissen der EMBRACE-Studien dargestellt.

Ergebnisse

Durch Kombination aus Teletherapie und Magnetresonanztomographie(MRT)-gestützter, kombiniert intrakavitärer/interstitieller, adaptiver Brachytherapie lassen sich, unabhängig vom lokalen Tumorstadium, lokale Kontrollraten von 92 % nach 5 Jahren und Gesamtüberlebensraten von 67 % nach 10 Jahren erreichen. Die kumulierte Nebenwirkungsrate Grad ≥ 3 nach Common Terminology Criteria for Adverse Events (CTCAE) beträgt dabei 11 % nach 5 Jahren.

Schlussfolgerung

Die primäre Radiochemotherapie unter Anwendung moderner strahlentherapeutischer Techniken ist die empfohlene Behandlung lokal fortgeschrittener Karzinome ab dem Stadium T1b2. Eine enge interdisziplinäre Zusammenarbeit ist von entscheidender Bedeutung.
Effects of two flap palatoplasty versus furlow palatoplasty with buccal myomucosal flap on maxillary arch dimensions in patients with cleft palate at the primary dentition stage: a cohort study
Authors: Aboulhassan Mamdouh Ahmed , Refahee Shaimaa Mohsen , Sabry Shaimaa , Abd-El-Ghafour Mohamed
Published: August 2023

Objective

The objective of this study was to evaluate the effect of two flap palatoplasty (TFP) versus Furlow palatoplasty with buccal myomucosal flap (FPBF) on maxillary arch dimensions in children at the primary dentition stage with cleft palate, in comparison to matching subjects without any craniofacial anomalies.

Material and methods

This study included 28 subjects with an age range of 5–6 years; 10 non-cleft subjects were included in the control group, 9 patients treated with TFP, and 9 patients treated with FPBF. For the included patients, the maxillary models were scanned using a desktop scanner to produce virtual models, and the maxillary dimension measurements were virtually completed. The produced measurements were compared between the 3 groups. Maxillary models of the 28 participants were evaluated.

Results

Statistically insignificant differences were detected between the 3 groups for arch symmetry measurements. Differences were detected in the inter-canine width between the 2 surgical groups and non-cleft group. Both arch length and posterior palatal depth significantly differ while comparing the TFP to the control group, with no differences between FPBF and the non-cleft group.

Conclusion

Furlow palatoplasty with buccal myomucosal flap might be considered a better surgical option than two flap palatoplasty for patients with cleft palate while evaluating maxillary arch dimensions at the primary dentition stage as a surgical outcome.

Clinical relevance

This study gives insight into the surgical technique that has limited effect on the maxillary growth and dental arch dimension. Therefore, it decreases the need for orthodontic treatment and orthognathic surgery.

Trial registration

clinicaltrials.gov (NCT05405738).
Evaluating user acceptance of knowledge-intensive business process modeling languages
Authors: Jalali Amin
Published: August 2023

Case Management has been evolving to support knowledge-intensive business process management, resulting in different modeling languages, e.g., Declare, Dynamic Condition Response (DCR), and Case Management Model and Notation (CMMN). A language will die if users do not accept and use it in practice—similar to extinct human languages. Thus, evaluating how users perceive languages is important to improve them. Although some studies have investigated how the process designers perceived Declare and DCR, there is a lack of research on how they perceive CMMN—especially in comparison with other languages. Therefore, this paper investigates and compares how process designers perceive these languages based on the Technology Acceptance Model. The paper includes two studies conducted in 2020 and 2022, both performed by educating participants through a course, with feedback on their assignments, to reduce biases. The perceptions are collected through questionnaires before and after feedback on the final practice. Results show that the perceptions change is insignificant after feedback due to the participants being well-trained. The reliability of responses was tested using Cronbach’s alpha. The results of the first study show that both DCR and CMMN were perceived as having acceptable usefulness and ease of use, but CMMN was perceived as significantly better than DCR in terms of ease of use. The results of the second study show that only DCR was perceived significantly better than Declare in terms of usefulness. The participants’ feedback shows potential areas for improvement in languages and tool support to enhance perceived usefulness and ease of use.
An Experimental Cold Gas Cannon for the Study of Porcine Lung Contusion and Behind Armor Blunt Trauma
Authors: Karlsson Tomas , Olsson Lars-Gunnar , Gustavsson Jenny , Arborelius Ulf P. , Risling Mårten , Günther Mattias
Published: August 2023

Behind armor blunt trauma (BABT) is a non-penetrating injury caused by the rapid deformation of body armor, by a projectile, which may in extreme circumstances cause death. The understanding of the mechanisms is still low, in relation to what is needed for safety threshold levels. Few models of graded kinetic energy transfer to the body exist. We established an experimental model for graded BABT. The cold gas cannon was air-driven, consisted of a pressure vessel, a barrel, and a pressure actuator. It required short training to operate and was constructed by standard components. It produced standardized expulsion of plastic projectiles with 65 mm and weight 58 g. Velocity correlated linearly to pressure (R 0.9602, p < 0.0001), equation Y = 6.558*X + 46.50. Maximum tested pressure was 10 bar, velocity 110 m/s and kinetic energy (Ek) 351 J. Crossbred male swine (n = 10) mean weight (SD) 56 ± 3 kg, were subjected to BABT, mean Ek (SD) 318 (61) J, to a fix point on the right lateral thorax. Pulmonary contusion was confirmed by physiological parameters pO2 (p < 0.05), SaO2 (p < 0.01), pCO2 (p < 0.01), etCO2 (p < 0.01), MPAP (p < 0.01), Cstat (p < 0.01), intrapulmonary shunt (Q′s/Q′t) (p < 0.05), and qualified trans-thoracic ultrasound (p < 0.0001). The consistent injury profile enabled for the addition of future experimental interventions.
Liquefaction analysis of soil plugs within large diameter monopiles using numerical modelling
Authors: Español-Espinel Carlos , Haigh Stuart K. , Madabhushi Gopal S. P.
Published: August 2023

Soil plug formation in open-ended piles due to pile driving is a widely studied phenomenon in onshore applications. The narrow diameters of traditional onshore piles ranging from 0.5 to 1.5 m facilitate plug generation during installation and transfer of enhanced confining stresses across the whole body of the soil plug. Offshore wind monopiles with larger diameters and smaller aspect ratios may not enhance confining stress within the soil plug as effectively as their onshore counterparts. Monopiles are currently the most widespread foundation in the offshore wind sector including in seismic areas. Earthquake shaking can lead to accumulation of excess pore pressure and subsequent liquefaction of the soil retained inside the plug. This research investigates the influence of monopile diameter and confining stress on the development of earthquake-induced excess pore pressure within the soil plug using fully coupled time domain Finite Element Analysis. The results presented in this paper reveal lower accumulation of earthquake-induced excess pore pressure in soil plugs subjected to confining stress. However, the influence of additional horizontal stress caused by monopile driving on the generation of excess pore pressure within the soil plug diminishes as the monopile diameter is progressively increased.
The impacts of Confucianism on gender inequality in Vietnam
Authors: Vu Tien Manh , Yamada Hiroyuki
Published: August 2023

We quantify the influences of Confucianism on gender inequality in present-day Vietnam. We use the number (or density) of the most successful test takers in the Vietnamese imperial examinations (1075–1919) in a given district as a proxy for mastering the subject of Confucianism. Using an instrumental variable approach based on the historical expansion of Vietnamese territory and distances to the test venues, we consider the effects on labor, health, and educational outcomes for females relative to males. We find that Confucianism has long-lasting negative impacts on gender inequality in all considered aspects. However, the results also suggest that when present-day females pursue more years of schooling, they tend to perform better than males.
Tick-Borne Pathogens Screening Using a Multiplex Real-Time Polymerase Chain Reaction-Based Method
Authors: Cardenas-Cadena Sergio Andres , Castañeda-Lopez Maria Eugenia , Mollinedo-Montaño Fabiana Esther , Vazquez-Reyes Sodel , Lara-Arias Jorge , Marino-Martinez Ivan Alberto , Rodriguez-Sanchez Iram Pablo , Garza-Veloz Idalia , Martinez-Fierro Margarita L.
Published: August 2023

Purpose

This study aims to develop and evaluate a cost-effective, user-friendly multiplex quantitative real-time polymerase chain reaction (qPCR) method for detecting multiple tick-borne pathogens associated with human and veterinary diseases.

Methods

In silico PCR was performed to design and evaluate primer sequences reported for amplifying Rickettsia spp., Borrelia spp., and Ehrlichia spp. Single and multiplex qPCR assays were then standardized to detect individual pathogens and multiple pathogens in a single reaction. Positive controls were generated to determine the dynamic range of the methods. In the validation phase, a total of 800 samples were screened for the presence of tick-borne pathogens.

Results

Identification in a single qPCR reaction (multiplex) of Ehrlichia spp., and Borrelia spp. with a limit of detection of 10 copies and Rickettsia spp. with 100 copies, a PCR efficiency (E) of 90–100% and a coefficient of correlation (R2) of 0.998–0.996 for all pathogens.

Conclusion

The ability to detect three significant pathogens (Ehrlichia spp., Rickettsia spp., and Borrelia spp.) in a single qPCR reaction offers a significant advantage in the field of molecular diagnostics for tick-borne diseases. This advancement has a profound impact on public health as it facilitates the selection of appropriate treatment protocols, thereby reducing complications associated with disease progression. The streamlined approach provided by this method simplifies the diagnostic process and enables timely intervention, ultimately improving patient outcomes and mitigating the potential risks associated with untreated or misdiagnosed tick-borne infections.
Obtaining Stable Predicted Distributions of Response Times and Decision Outcomes for the Circular Diffusion Model
Authors: Smith Philip L. , Garrett Paul M. , Zhou Jason
Published: August 2023

The circular diffusion model represents continuous outcome decision making as evidence accumulation by a two-dimensional Wiener process with drift on the interior of a disk, whose radius represents the decision criterion for the task. The hitting point on the circumference of the disk represents the decision outcome and the hitting time represents the decision time. The Girsanov change-of-measure theorem applied to the first-passage time distribution for the Euclidean distance Bessel process yields an explicit expression for the joint distribution of decision outcomes and decision times for the model. A problem with the expression for the joint distribution obtained in this way is that the change-of-measure calculation magnifies numerical noise in the series expression for the Bessel process, which can make the expression unstable at small times when the drift rate or decision criterion is large. We introduce a new method that uses an asymptotic approximation to characterize the Bessel process at short times and the series expression for the large times. The resulting expressions are stable across all parts of the parameter space likely to be of interest in experiments, which greatly simplifies the task of fitting the model to data. The new method applies to the spherical and hyperspherical generalizations of the model and to versions of it in which the drift rates are normally distributed across trials with independent or correlated components.
Nonlinear optical absorption and optical limiting of magnetic iron oxide nanomaterials
Authors: Helayl Shaimaa , Hassab-Elnaby Salah , Badr Yehia , Salah Abeer
Published: August 2023

Integration of nanoparticles into polymeric materials enhances the optical properties and stability of the formed nano-composite materials. In this work, magnetic iron oxide nanoparticles Fe3O4NPs were prepared via chemical coprecipitation. In addition, it is polymerized in a host of polyvinylpyrrolidone PVP. The prepared iron oxide nano-size was about 14.0 nm as confirmed by Transmission Electron Microscopy, A vibrating sample magnetometer VSM studies showed Fe3O4NPs possess superparamagnetic behavior. Energy-dispersive X-ray spectroscopy, and X-ray diffraction confirmed the structure and composition of Fe3O4NPs. Open aperture Z-scan and optical limiting experiments were carried out at nanosecond pulses of wavelength 532 nm. The nonlinear absorption coefficients were calculated for the colloidal and polymeric iron oxide. Fe3O4NPs polymeric film exhibits enhanced nonlinear optical properties NLO, and superior optical limiting properties compared to Fe3O4NPs colloidal solution. That makes Fe3O4 nanocomposites a promising candidate for optical limiting applications.
Affect Across the Wake-Sleep Cycle
Authors: Sikka Pilleriin , Gross James J.
Published: August 2023

Affective scientists traditionally have focused on periods of active wakefulness when people are responding to external stimuli or engaging in specific tasks. However, we live much of our lives immersed in experiences not related to the current environment or tasks at hand—mind-wandering (or daydreaming) during wakefulness and dreaming during sleep. Despite being disconnected from the immediate environment, our brains still generate affect during such periods. Yet, research on stimulus-independent affect has remained largely separate from affective science. Here, we suggest that one key future direction for affective science will be to expand our field of view by integrating the wealth of findings from research on mind-wandering, sleep, and dreaming to provide a more comprehensive account of affect across the wake-sleep cycle. In developing our argument, we address two key issues: affect variation across the wake-sleep cycle, and the benefits of expanding the study of affect across the full wake-sleep cycle. In considering these issues, we highlight the methodological and clinical implications for affective science.
Production, purification, and characterization of cold-active lipase from the psychrotroph Pseudomonas sp. A6
Authors: Abdella Bahaa , Youssif Asmaa Mohamed , Sabry Soraya A. , Ghozlan Hanan A.
Published: August 2023

Cold-active lipases are presently employed extensively in the detergent, chemical intermediate, fine chemical, food, and pharmaceutical industries. Seven cold-adaptive bacteria were isolated from the Mediterranean Sea near Alexandria, Egypt, and tested for their ability to produce cold-active lipase, with the highest activity at 10 °C. The most potent isolate was Pseudomonas sp. A6. To determine the most important variables, the bacterium was exposed to a necessary medium component and environmental factor screening using a single factor-at-a-time approach, followed by a multifactorial Plackett-Burman design strategy. After purification and characterization, the optimal activity levels for the cold-active lipase were figured out. Inoculation of Pseudomonas A6 under near optimum conditions using medium consisting of (g/L) peptone 7.14; soybean oil 7.5% (v/v); K2HPO4, 0.4; MgSO4, 0.1; glucose 2; pH 8; and temperature 10 °C led to a maximum lipase activity anticipated to be 23.36 U/mL. Purified lipase showed the best activity and thermal stability at a pH of 8 and a temperature of 10 °C. The Pseudomonas A6 lipase tolerated the monovalent ions, while greater valence ions did not.
Crystallization between (100) Goethite and (001) Orientation of Hematite – A Review
Authors: Wang Ming Kuang , Yang Puu-Tai , Chuang Tsung-Ju , Ou C. Chachi , Wang Shan Li
Published: August 2023

The purposes of this study were: (1) to review the preparation and characterization of the intergrowth between goethite and hematite crystals; and (2) to propose a schematic diagram of the epitaxial relationships among three sets of (100) goethite twin crystals associated with the (001) orientation of the hexagonal prism of hematite. The Fe(ClO4)3 solution was prepared and aged at 70°C, which precipitated goethite initially and produced hematite later with prolonged aging. Goethite and hematite aged for 20 days were observed as star-shaped and hexagonal prisms, respectively. The results suggest that hematite could form later using goethite as a template surface. A selected area electron diffraction (SAED) pattern showed the epitaxial relationship among three sets of (100) goethite intergrowth crystals and hexagonal prisms with the (001) orientation of hematite. Goethite can be produced as lath-, X-, K-, or star-shaped crystals on the (100) orientation, depending on the Fe(ClO4)3 concentrations and the addition of HClO4 to Fe solution samples which were aged for a prolonged period at room temperature. The initial solubility products [(Fe3+)(OH–)3] of the sample solution, rather than the nature of the nuclei, are the key factors governing the formation of goethite or hematite. The addition of acids and high concentrations of iron solutions extend the secondary hydrolysis and induction period (IP) and favor the formation of hematite. The index of the SAED pattern of the star-shaped goethite intergrowth twin crystal has a (100) plane parallel to this basal plane and rotates at a 60° angle between two or three sets of lath-shaped goethite crystals, which share the (011) plane and form goethite twins with ‘interpenetrated’ crystal growth. Stereoscopic viewing using Oak Ridge Thermal Ellipsoid Plot (ORTEP) and CrystalMaker software was deployed to explore the relationship and configuration of oxygen atoms between pseudo-hexagonal (100) goethite associated with hexagonal (001) hematite lattice planes. A schematic diagram of the epitaxial relationship between star-shaped (100) goethite, which is acting as a template facilitating later precipitation of (001) hexagonal prisms of hematite on it, is presented.
Condition transfer between prestressed bridges using structural state translation for structural health monitoring
Authors: Luleci Furkan , Necati Catbas F.
Published: August 2023

Implementing Structural Health Monitoring (SHM) systems with extensive sensing layouts on all civil structures is obviously expensive and unfeasible. Thus, estimating the state (condition) of dissimilar civil structures based on the information collected from other structures is regarded as a useful and essential way. For this purpose, Structural State Translation (SST) has been recently proposed to predict the response data of civil structures based on the information acquired from a dissimilar structure. This study uses the SST methodology to translate the state of one bridge (Bridge #1)to a new state based on the knowledge acquired from a structurally dissimilar bridge (Bridge #2). Specifically, the Domain-Generalized Cycle-Generative (DGCG) model is trained in the Domain Generalization learning approach on two distinct data domains obtained fromBridge #1; the bridges have two different conditions:State-HandState-D. Then, the model is used to generalize and transfer the knowledge onBridge #1toBridge #2. In doing so, DGCG translates the state ofBridge #2to the state that the model has learned after being trained. In one scenario,Bridge #2’s State-His translated toState-D; in another scenario,Bridge #2’s State-Dis translated toState-H. The translated bridge states are then compared with the real ones via modal identifiers and mean magnitude-squared coherence (MMSC), showing that the translated states are remarkably similar to the real ones. For instance, the modes of the translated and real bridge states are similar, with the maximum frequency difference of 1.12% and the minimum correlation of 0.923 in Modal Assurance Criterion values, as well as the minimum of 0.947 in Average MMSC values. In conclusion, this study demonstrates that SST is a promising methodology for research with data scarcity and population-based structural health monitoring (PBSHM). In addition, a critical discussion about the methodology adopted in this study is also offered to address some related concerns.
Direct and indirect barriers to hypothetical access to care among Canadian forces health services personnel
Authors: Born Jennifer , Frank Christine
Published: August 2023

Background

Though research among Canadian Forces Health Services (CFHS) personnel is limited, the literature suggests formal healthcare is underused. Though much research has been conducted on particular barriers (e.g., stigma), examining a breadth of barriers could better inform behavioral interventions. Furthermore, work has yet to examine the indirect effects of barriers through their impact on intentions to access care.

Methods

CFHS participants were randomly assigned to complete either a mental health (N = 503) or physical health (N = 530) version of the survey. The survey included questions on the perceived impact of barriers, health-related information (e.g., past access to care), intention to seek care, and two hypothetical scenarios (i.e., pneumonia and back injury or post-traumatic stress disorder and depression) as a proxy of access to care. Multiple regressions using Hayes PROCESS macro were conducted to assess the direct and indirect effects (through intentions) of the barriers on hypothetical access to care.

Results

Results show conflict with career goals barriers were indirectly linked to all health outcomes, and directly linked to mental health outcomes. Treatment preference barriers were directly and indirectly linked to care seeking only for mental health, while resource barriers were directly linked to care seeking only for physical health. Knowledge and ability to access care barriers were directly linked to care seeking for depression and pneumonia.

Implications

Interventions to improve treatment-seeking should be developed only after the behavioural antecedents are understood, and should focus on combining evidence-based techniques to simultaneously target multiple aspects of the behaviour.
Measuring Gelotophobia, Gelotophilia, and Katagelasticism in Italy	and Canada Using PhoPhiKat-30
Authors: Lau Chloe , Chiesi Francesca , Fermani Alessandra , Muzi Morena , del Moral Arroyo Gonzalo , Bruno Francesco , Ruch Willibald , Quilty Lena C. , Saklofske Donald H. , Canestrari Carla
Published: August 2023

Abstract: The PhoPhiKat-30 is a self-report instrument for describing personality related to laughter and ridicule including gelotophobia, gelotophilia, and katagelasticism. The present study assessed the measurement properties of the newly translated Italian PhoPhiKat-30 across participants in Italy and Canada using multidimensional item response theory. Italian ( N = 326) and Canadian ( N = 1,467) participants completed the Italian and English PhoPhiKat-30, respectively. The parallel analysis supported the three-factor model in Italy. Conditional reliability estimates showed strong precision (> 0.80) of gelotophobia and gelotophilia along the latent continuum (−1.15 < θ < 3.08 and −1.69 < θ < 3.09, respectively). Katagelasticism showed a limited range (0.98 < θ < 2.85) for the latent attribute precisely measured, suggesting that new items that address the low to moderate difficulty of katagelasticism should be added in future studies. Item discrimination parameters varied across Reckase’s multidimensional normal-ogive model (MDISC mean = 0.79). Five items had uniform differential item functioning (DIF; McFadden’s pseudo R2 > .035 or β > .10) when comparing the Italian and English PhoPhiKat-30, with English items showing more agreement at the same level of the latent trait. The Italian PhoPhiKat-30 has good item discrimination across the latent continuum and showed cross-cultural equivalence for most items.
Scientists Discover a Way of Forming Suspended Layers of Sediment
Authors: Kornei Katherine
Published: August 2023

Laboratory experiments suggest that underwater gas eruptions—due to the venting of gas hydrates, for example—could trigger the formation of layers of suspended sediment in the ocean.
An Observational Study of Short‐Cycle Lightning Outbreaks in the Inner Core of Typhoon Hato (2017) Before Landfall
Authors: Xu Yuanyuan , Huang Hao , Li Qingqing , Zhao Kun , Chan Pak‐Wai , Ming Jie , Fan Xueqi , Yang Zhengwei , Zhang Wenjuan , Lyu Weitao , Duan Yihong , Song Ping
Published: August 2023

This study analyzes microphysical signatures relevant to the short‐cycle lightning activity in the inner core of Typhoon Hato (2017) before landfall in China. Observations reveal that the lightning bursts were accompanied by enhanced inner‐core convection with a behavior cycle of about 3 hr. The coupling between wavenumber‐2 vortex Rossby waves (VRWs) and shear‐forced convective asymmetries resulted in a local updraft enhancement. Furthermore, supercooled liquid water droplets invigorated a striking enhancement of graupel via riming immediately above the freezing level, further enhancing charge separation and lightning generation outside the eyewall. Furthermore, when similar phase‐locking was associated with other propagating VRWs, graupel and updraft volumes were significantly boosted, leading to short‐cycle lightning outbreaks in the inner core.