bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemikiran Nyai Nur Rofiah Dalam Buku Nalar Kritis Muslimah dan Relevansinya Terhadap Kekerasan Verbal Anak Usia Dini
Authors: Oktaria Herlega , Syafri Fatrica , Eliya Ixsir
Published: July 2022

Permasalahan yang diangkat dalam penelitian ini adalah konsep pemikiran Nyai Nur Rofiah dan bertujuan untuk mengetahui pemikiran Nyai Nur Rofiah dalam buku Nalar Kritis Muslimah terhadap kekerasan verbal anak usia dini. Penelitian ini menggunakan jenis penelitian yaitu  penelitian kepustakaan (library research). Teknik pengumpulan data yaitu menghimpun literatur. Data yang digunakan berasal dari data primer serta data sekunder. Hasil  penelitian  dapat  disimpulkan  bahwa pemikiran Nyai Nur Rofiah dalam buku nalar kritis muslimah tentang  perempuan dan gender penting bagi manusia mengetahui perbedaan laki-laki dan perempuan  yang dibedakan oleh dua hal yaitu jenis kelamin dan gender. Dalam penelitian yang peneliti teliti pengaruh orang tua terhadap perkembangan anak sangatlah besar. Karena anak dengan umur 0-8 tahun itu sangat rentang terhadap perilaku-prilaku yang kurang baik. Karna pada umur tersebut anak sangat suka sekali mencontoh sesuatu yang dilakukan oleh lingkungan serta kedua orang tuanya. Oleh sebab itu orang tua harus selalu mmberikan cinta serta apresiasi yang baik kepada anaknya. Maka dari penjelasan yang peneliti pahami dari buku ini, memiliki relevansi terhadap kekersan verbal terhadap anak usia dini.
Survei dan Identifikasi Faktor Awareness Mahasiswa IPB terhadap Perilaku Pelecehan Seksual dan Kekerasan Menggunakan Regresi Logistik Biner
Authors: Muhammad Ibrahim Arif , Anisa Rahma , Masjkur Mohammad
Published: July 2022

The lack of public awareness of sexual harassment as well as physical and verbal abuse are still occurring frequently and becoming a concern in everyday life, especially for women. Sexual harassment is an unwanted behavior or attention from a perpetrator with sexual intentions that disturbs the victim(s). Abuse is a form of one person's action against another party that results in pain and changes both physically and psychologically. The purpose of this study is identifying the number of IPB University students that are aware on the act of sexual harassment and abuse, identifying factors that can affect awareness about it using binary logistic regression, and providing recommendations on how to increase the awareness of it. Majority of the respondents have awareness on both the act of sexual harassment and abuse, whether they have done it or not. In the logistic regression, gender and financial background of the respondents were significant factors of awareness in the act of sexual harassment, whereas in awareness of the abusive behavior, the respondents’ gender, hometown, the time amount of social media usage per day, financial background, and experience of being a victim of it factor significantly. Majority of the respondents suggest that education from various sources should be improved in order to raise awareness to the public.
Dead sea salt solution: composition, lack of cytotoxicity and in vitro efficacy against oral leukotoxins, endotoxins and glucan sucrose
Authors: Hessam Nowzari , Mao-Chi Tuan , Michael Jorgensen , Marie-Grace Michel , Jean-Francois Michel
Published: July 2022

Introduction: Dead Sea Salt, rich in minerals and ionic compositions and low in Sodium Chloride (NaCl) has many reported unique properties that set it apart from other salts. Objectives: To evaluate the composition of Dead Sea Salt and assess its in vitro cytotoxicity, and efficacy against oral bacterial leukotoxins, oral endotoxins and oral glucan sucrase. Methods: The cytotoxicity was evaluated in an established cell line (solution at 5000 µg/mL of culture medium) using positive and negative control groups. The effect on oral bacterial leukotoxin (LtxA) and different concentrations of lipopolysaccharide and glucan sucrase was established at 24, 36, 48, 60, 72, 84, and 96 hours using the HPLC method (high-performance liquid chromatography). Results: The most predominant elements detected were the water of crystallization (H2O, water that is found in the crystalline framework of salt and which is not directly bonded ), magnesium chloride (MgCl2), potassium chloride (KCl), sodium chloride (NaCl), calcium chloride (CaCl2), bromide (Br -) and sulfates (SO4). In vitro, Dead Sea Salt presented no cytotoxicity and was highly effective against leukotoxin, endotoxin, and glucan sucrase enzyme. Conclusion and clinical significance: We believe that rinsing with Dead Sea Salt has the potential to contribute to the prevention of periodontal, peri-implant and dental disease and merits clinical research.
Exploration of teachers’ teaching practices of Early Childhood Care and Education (ECCE) utilize in different contexts; A literature Review
Authors: Syeda Sumbul Shah  , Surhan Rafique  , Sayeda Sapna Shah  , Shahar Bano
Published: July 2022

This literature review is about the exploration of teachers’ teaching practices of Early Childhood Care and Education (ECCE) teachers utilized in different context’.  The findings of this study are based on literature published between the years 2000 and 2020. This document is established as a current analysis of teaching practices of ECCE teachers.  The limitation of this paper is that the majority of the study is based on Australia, UK, France, Germany, Pakistan Australia, and USA which restricts the results' worldwide application. The results are presented in seven comprehensive themes; Early Childhood Care and Education (ECCE), Importance of Early Childhood Care and Education, Global status of Early Childhood Care and Education, Challenges in Early Childhood Care and Education, Strengthening in Early Childhood Care and Education, best teaching practices in Early Childhood Care and Education and teaching practices utilized by ECCE teachers in different contexts. At the root, all of these themes reveal the practices of ECCE teachers in different context. This study is directly linked to policymakers, educationist, government leaders, community members, researchers and parents who are interested to make early childhood education more effective and appropriate. However from this literature review it is found that ECCE teachers are not much practicing the effective teaching practices in their classrooms just as; collaborative activity, interactive activity, Hands-on or project based activities. Even it is also found that in many contexts in ECCE physical and social environment was not much conducive for children in order to make their learning effective.
Estimation polypropylene elbow losses
Authors: Arman Mohammed Abdalla  , Muhab Salahaldien Shalby  , Tyseer Yhya Mustafa
Published: July 2022

Normally the values of losses in plastic pipe and fitting is small in most cases was neglected, the paper was estimate the coefficient for Polypropylene elbow losses by using experimental model consist of 18 elbows and it was K=1.77, also the paper describes the methodology can be estimate all values of minor losses.
The use of antibiotic drugs associated with the onset of symptoms of Spinocerebellar Ataxia disease
Authors: Gustavo Simões Carnivali
Published: July 2022

This case report reports the onset of symptoms of a disease. Spinocebellar Ataxia (unknown type) is studied, a genetic, neurodegenerative disease that commonly starts in adulthood. A case is reported in which the onset of symptoms of this disease, in the patient, possibly starts after the ingestion of a set of antibiotics in a short period of time. Several works in the literature report the onset of symptoms of this disease by the use of antibiotics. This study reaffirms previous studies.
Microbial processing of tannery waste for compost production in the growth and quality improvement of ornamental plants
Authors: Domenico Prisa  , Girolamo Centomo
Published: July 2022

Research goal: The article presents research results that aim to highlight microbial activity in the composting process of waste from tanning industries. The various steps of the compost production process with microbial inocula and the resulting stable material for the production of growing substrates for ornamental plants are emphasised. Materials and Methods: The experimentation was divided into two phases, a first part of the transformation of tannery waste by microbial activity took place at the company Sirp spa (VR), and the second part of the evaluation of the material for plant cultivation was carried out at the CREA-OF greenhouses in Pescia (PT). The experimental theses involved using peat and biological sludge, respectively, treated with microorganisms in liquid form, supplemented with a solid matrix colonised by microorganisms, and added with sugar cane molasses. Results and Discussion: The test showed that it was possible to cultivate Delosperma cooperi plants on biological sludge treated with microorganisms, showing an improvement in the agronomic characteristics of the plants and substrates in which the microorganisms were inoculated during the composting phase. In general, a significantly more significant improvement in the theses treated with liquid microorganism solution than when a solid organic matrix was used as a substrate for inoculating the microorganisms. Furthermore, the biological sludge treated with microorganisms was better than the peat controls and those treated with sugar cane molasses alone. Furthermore, the untreated biological sludge thesis was the worst of all the theses tested. Finally, the trial also showed how the use of microorganisms could positively and significantly influence the reduction of some essential industrial contaminants in biological sludge after only six months of treatment. Conclusions: This research may interest growers who want to reduce synthetic chemicals in agriculture and are concerned about sustainability, but also those companies whose primary goal is to produce new substrates as an alternative to peat and who are looking for new matrices. Also, for those industries that are environmentally friendly and want to transform the waste produced by their industrial processes and reuse it, perhaps to grow ornamental plants.
Preliminary phytochemical screening for various secondary metabolites, quantitative and qualitative analysis of Yemeni brown seaweed Sargassum vulgare
Authors: Diana Faisal al-hashdy  , Amina Mohammed El-Shaibany  , Salwa Mohammed Raweh  , Abdulrahman Abdullah Humaid  , Mahmoud Mohamed El –Aasser
Published: July 2022

Sargassum Vulgare was collected from the Red sea coastlines, Al-Hodeida, Yemen, and dried. The dried powder was subjected to consecutive extraction by methanol. The dried methanol extract was subjected to solvent fractionation (n-hexane-chloroform-ethyl acetate and n-butanol solvents). Sargassum vulgare polysaccharides (S.R1P, S.R1M, S.R5s, and S.R5ss) were isolated by precipitation with methanol. [19] The methanol extract and n-hexane fraction were evaluated phytochemically. The physicochemical characteristics and FT-IR analysis of Sargassum vulgare polysaccharides (S.R1P, S.R1M, S.R5s, and S.R5ss) were investigated, the chemical composition of the Sargassum vulgare n-hexane fraction was evaluated by Gas Chromatography-Mass Spectrometry (GC-MS) analysis [8]. Phytochemical investigation revealed that both methanol extract and n-hexane fraction of Sargassum vulgare contained alkaloids, phytosterols, terpenoids, fats, and fixed oils. Moreover, Sargassum vulgare methanol extract exhibited a high amount of carbohydrates (41.33%) mainly polysaccharides [40][41][42]. The physicochemical characteristics and FT-IR analysis of polysaccharides (S.R1P, S.R1M, S.R5s, and S.R5ss) revealed that all the obtained polysaccharides were alginates with traces of sulfate polysaccharides except S.R1M. [30][34][35]
Assessment of oxidative and cardiovascular changes in pregnant women attending antenatal clinic at Federal Medical Centre, Owerri Nigeria
Authors: Kelechi Chinaemenkwa Eziechile  , Cyprian Emeka Oguji  , Ikechukwu Johnpaul Chukwu  , Ikechukwu Johnpaul Chukwu  , Kelvin Nkemakonam Orji  , Melvina Nnedimma Ogakwu  , Ifunanyachukwu Confidence Onuchukwu  , Kelechi Victor Ihedi  , Oluwapelumi Andrew Eseola  , Prince Ikechukwu Onuoha  , Sheudeen Abubakar Abiola  , Chinazom Destiny Chima  , Emmanuel Chisom Ani  , Tobenna Anthony Onyemeh
Published: July 2022

Background: In pregnancy which is a physiological state that is accompanied by high energy demand, there is an increased intake and utilization of oxygen, hence augmented levels of oxidative changes that are associated with a lot of risks, one of which is cardiovascular diseases. This research aims to investigate the oxidative changes that occur among pregnant women by determining the levels of High Sensitivity c-Reactive Protein (hs-CRP) and Oxidized Low-Density Lipoprotein (OxLDL) in first, second and third trimesters. Materials and Methodology: A total of 60 pregnant women were recruited for the study. Twenty (20) pregnant women each from the three trimesters while Twenty (20) non-pregnant pubertal women without any chronic disease were used as control. 5ml of venous blood was collected from all subjects and analyzed for OxLDL and hs-CRP using an Enzyme-Linked Immunosorbent Assay (ELISA) technique. The data were analyzed using Statistical Package for the Social Sciences (SPSS) version 18. Results: Oxidized Low-Density Lipoprotein (OxLDL) showed mean variations across the groups but was not significant (P>0.05) but Pregnant women in their second trimester showed significant mean variation (P<0.05) (3716.11±599.86) in when compared to non-pregnant women (control) (4305.33±68.90) respectively. Pregnant women in the second trimester showed significantly decreased mean variation (P<0.05) in High sensitivity C-reactive protein (85.09 ±12.38) when compared to non-pregnant women (control) (219.45 ±64.61) respectively. Conclusions: This study shows that there are increases in levels of OxLDL and a decrease in plasma concentration of hs-CRP which are more significant in the second trimester.
Molecular identification of non-lactic acid bacteria isolated on MRS medium and associated to the production of biogenic amines in adjuevan, a fermented fish of Côte d’Ivoire
Authors: Marina Ghislaine Abre  , Didier Kra Brou Kedjebo  , Constant Kouadio Attchelouwa  , Guillaume Octave Ehouman  , Clémentine Amenan Kouakou-Kouame  , Florent Kouadio N’guessan
Published: July 2022

Biogenic amines (BAs) are important nitrogenous compounds formed mainly by decarboxylation of amino acids or by amination and transamination of aldehydes and ketones. That compounds have been detected in adjuvant, a fermented fish very used as condiments in Côte d’Ivoire. The aim of this study was to identify non-lactic acid bacteria (non-LAB) populations isolated in adjuevan on MRS agar and producing biogenic amines. Thus, non-LAB were isolated on MRS agar, then their biogenic amines production was highlighted on Niven agar. Finally, the isolates which produce biogenic amines were identified by sequencing the 16S DNA region. The results showed that non-LAB was able to grow on MRS agar. Their charges obtained in adjuevan were between 1.3x103 and 1.95x105 UFC/g. Those bacteria were also detected during the storage of adjuevan at ambient temperature and 4°C until six weeks. The prevalence of non-LAB producing biogenic amines was from 8.8 to 100% at ambient temperature and 57% at 4°C in adjuevan produced with Chloroscombrus chysurus. This prevalence was between 21 and 50% at ambient temperature and 55% at 4°C in adjuevan produced with Galeoides decadactylus during six weeks of storage. However, this prevalence was low in the adjuevan produced with Thunnus thynnus. The species found by molecular identification were Staphylococcus saprophyticus, Staphylococcus kloosi, Staphylococcus gallinarum, Staphylococcus arlettae, Staphylococcus cohnii, Bacillus subtilis subsp. subtilis, Pseudomonas sp., Enterococcus faecalis, Streptococcus pyogènes and Enterobacter sichuanensis. Staphylococcus saprophyticus was the most detected biogenic amines-producing species with over 71% of strains.
Investigation of leaves of Xylocarpus granatum as a larvicide agent against Aedes aegypti and its associated anti-bacterial properties
Authors: Sunelsya Surya  , Delianis Pringgenies  , Wilis Ari Setyati  , Muhammad Syaifudien Bahry
Published: July 2022

Mangrove is a coastal plant that has rich benefits. This research aimed to investigate X. granatum leaves extract as a mosquito larva eradicator and find the antibacterial activities of its bacteria. The eradicator test was done for 24 and 48 hours. As many as 10 pieces of cups, filled with 50 ppm, 100 ppm, 250 ppm, 500 ppm, and 1000 ppm of X. granatum leaves extract. Each cup contains 10 mosquitoes (Aedes aegypti). Probit LC50 test was carried out from X. granatum leaves extract and an antibacterial test was carried out by isolating bacteria from X. granatum leaves. The survival rate percentage of larvae in X. granatum leaves extract, the highest was 50% at 24 and 48 hours and the lowest was 0% at 48 hours. The result of the probit test shows 426,618 mg/L at 24 hours and 100,193 mg/L at 48 hours, categorized as a toxic compound. There were a total of 7 pure isolates obtained. Antibacterial tests showed the antibacterial activity of isolates against Staphylococcus aureus, Vibrio harveyii, and Vibrio alginolyticus, with the result being 3 isolates (XGL1, XGL2, and XGL3), 2 isolates (XGL6 and XGL7), and 4 isolates (XGL2, XGL3, XGL6, and XGL7). Based on the results, 1000 ppm X. granatum leaves extract has the potential as a mosquito larva eradicant or Phyto-insecticide. In addition, there were symbiont bacteria in X. granatum leaves that were potentially used as larva eradicant.
Characterization of Campylobacter spp. isolated from chicken and at-risk people (children) in Cameroon: A review
Authors: Serge Damase Oyong Assiene  , Esther Ngah  , Dieudonné Ndjonka
Published: July 2022

Campylobacteriosis is a disease caused by the bacteria called Campylobacter spp, it is considered a public health problem. Campylobacter spp has so far been identified as the pathogen most responsible for bacterial gastroenteritis. Emphasis was placed on controlling the foodborne route of exposure. The assessment of the actual burden of Campylobacter in the African context, particularly in Cameroon, is hampered by the lack of reporting of diarrheal incidents and the ineffectiveness of monitoring and surveillance programs for foodborne illnesses, as well as the lack of attention given to Campylobacter as a causative agent of diarrhea for the sole benefit of Salmonella. This article aims to report on the characterization of Campylobacter spp in infected chickens and children in Central Africa, more specifically in Cameroon. Campylobacter infection is more prevalent in the pediatric population and has been isolated from farm animals, particularly chickens and foods of animal origin. The prevalence of Campylobacter in children with diarrhea under five years of age ranges from 15% to 23% in Angola. In chickens, the prevalence varies from 90% in Cameroon to 41.2% in Congo. This review also highlights the increased resistance of Campylobacter to common important antimicrobials, such as ciprofloxacin, tetracycline and erythromycin, in food animals and humans in Central Africa. The solution to limit the incidence in humans is to control and prevent the spread of pathogens in animals constituting the main reservoir of infections.
Mass transfer of magnetic drug on lipoprotein during MHD blood in an arterial channel
Authors: Nnoka Valentine Nwobuike  , Woha Boobandah James  , Nmehielle Ihundah  , Enebeli Sarah Kelechi
Published: July 2022

Mathematical models were used in the investigation of mass transfer of magnetic drug on lipoprotein during mhd blood in an arterial channel. The non-linear partial differential equations were changed into linear partial differential equations and were then solved analytically to obtain the exact solutions. The numerical results were obtained through plots showing the parameter variations on their effects on the focus of the study. With the help of graphs parameters such as Grashof number, Schmidt number, and magnetic parameter were determined. The significance of this study is on the therapeutic analysis of hyperthermia more especially on the regulation of blood flow and lipid in blood.
Iron (III) adsorption on perlite
Authors: Neli Kalabegashvili  , Gulnara Balarjishvili  , Dali Ioseliani  , Liana Samkharadze  , Nino Nonikashvili  , Irma Mikadze
Published: July 2022

The present research set a goal of study of applicability of the expanded perlite obtained on the basis of perlite – natural mineral of Georgia, from adsorption removal of Fe3+ ions from aqueous solution. Adsorptive characteristics of the expanded perlite have been studied in the process of aqueous solution purification from trivalent iron ions in regard to adsorbent dosage, contact time, adsorbate concentration and solution pH. The dependence of adsorption degree and adsorptive capacity of the expanded perlite from the above-mentioned parameters have been uncovered. Optimum conditions of Fe3+ ions adsorption have been established. Maximum values of adsorption degree and adsorptive capacity were equal to 89% and 4,45mg/g, respectively.
The effectiveness of counseling using videos with demonstrations of dental brushing on improving dental health knowledge of students of SDN 3 Sila in the region remote, disadvantaged by borders and islands (DTPK)
Authors: Ranita silantika  , Indah Kartikasari
Published: July 2022

Background: Dental caries is still one of the maximums not unusualplace preventable persistent illnesses in children. Likewise, children at SDN 3 SILA in the Remote, Disadvantaged, Border and Archipelago (DTPK) areas also have the same right to obtain optimal degrees of oral health. Purpose: The purpose of this study was to determine the effectiveness of counseling using videos accompanied by demonstrations of brushing teeth to increase dental health knowledge of students at SDN 3 Sila in the DTPK area, Bima Regency, NTB, Indonesia. Material and Methods: This form of studies makes use of a quantitative descriptive approach with a cross sectional approach. The college students who had been sampled on this examine had been magnificence V college students with a complete of 24 people. Education is carried out using a learning approach using educational videos and after that a demonstration of brushing teeth is carried out. Evaluation will be carried out using a pretest and post-test design. analysis test used paired sample t-test with 95% confidence level and processed using IBM SPSS 21. Results: statistical test paired sample t-test before and after being given counseling showed an increase in students' knowledge and skills (p<0.05). Conclusion: providing counseling using video media accompanied by a demonstration of brushing teeth can increase students' knowledge so that it can be an effort to improve dental and oral hygiene for elementary school students who live in remote, remote, and island areas (DTPK).
Opioid for in-hospital admitted patient analgesics; which demographics and psychiatric profiles need more pain drugs?
Authors: Tahereh Mohammadi  , Elham Sharafi  , Atieh Sadeghniiat-Haghighi  , Farzan Vahedifard  , Arghavan Shafiee-Aghdam  , Mohammad Arbabi
Published: July 2022

Introduction: The prevalence of substance use disorders is higher in patients receiving opioid analgesics, and pain management in these patients is more challenging. This study aimed to investigate the pattern of analgesic drug administration and evaluate the associated factors. Method: The cross-sectional study was performed on 230 patients admitted to General Hospital ( internal medicine, surgery, and cancer wards). Result: The most used analgesic drug was morphine (59.4%), and a mean dose of 27 mg, then pethidine and methadone. Most pain control methods were intravenous (68.1%) and PRN pattern (61.1%). Using analgesics in patients who do not have risk factors for drug abuse, or addiction, can be considered safe. In our subjects, 95.6% of analgesic users did not become addicted or had any misuse. Discussion and Conclusion: For effective and low-risk treatment of these patients, there is a need for clinical skills, knowledge of opioid administration, assessment, and risk management of substance abuse and addiction. In patients with substance abuse, analgesics should be prescribed in a particular setting, under supervision, and with careful monitoring. Structured and planned administration of opioid agonists (such as methadone or buprenorphine) seems appropriate according to a structured schedule. These plans are recommended: · Increasing the awareness of clinicians about prescribing narcotic analgesics. · Prescribing narcotic analgesics with a regular pattern against PRN. · Evaluating patients for a history of substance abuse. · Closely monitoring them, and if necessary. · Counseling. Identifying high-risk groups such as women, youth, and psychiatric patients are also recommended, and performing early interventions.
Malignant Bowel Obstruction in Ovarian Cancer Recurrence: The Role of Palliative Surgery in a Decision-Making Process
Authors: De Crescenzo Eugenia , Fontana Marianna , Dondi Giulia , Friso Stefano , Bovicelli Alessandro , Di Stanislao Marco , Tesei Marco , De Palma Alessandra , Chieco Pasquale , Rottoli Matteo , Bernante Paolo , Ravegnini Gloria , Perrone Anna Myriam , De Iaco Pierandrea
Published: July 2022

Background: Malignant bowel obstruction (MBO) is often the latest stage in ovarian cancer (OC). The therapy of this condition ranges from medical waiting to surgery. The objective of this pilot study is to compare the two strategies so that we can provide a path forward for future studies. Methods: From 700 women diagnosed with OC in the database of the Division of Gynecologic Oncology we crossed the names of those admitted by the emergency services of the IRCSS Azienda Ospedaliero Universitaria of Bologna, Italy. We selected MBO patients with a history of OC as the only neoplastic condition and compared the results between medical conduct and surgery to restore intestinal transit. Results: Of the 700 women in our database, 36 were eligible for study according to the inclusion and exclusion criteria: 9 in surgery group and 27 in medical group. Surgical conduct (tumor biopsy and stoma) appears to be resolutory for the obstruction and have a better result than medical therapy regarding recurrence of MBO, despite the development of greater complications. Relapses of MBOs occurred in 11% of surgical patients and 44% of medical patients (p = 0.0714). Furthermore, after surgical treatment, five patients (55%) experienced postoperative complications; in four cases, severe anemia requiring blood transfusion, while one patient developed post-surgical sepsis, which evolved into multiple organ failure and death. Of the 9 patients treated surgically, 2 (22%) were given surgery as a first choice. In most cases (78%), surgery was decided upon when medical treatment failed. The only discriminative factor appears to be age. The length of hospitalization increased with the patient’s age (p = 0.0181) as statistically significant factors for a worse outcome in surgery. Conclusions: MBO requires complex and multidisciplinary management where different factors need to be considered before initiating surgical therapy. Future studies are needed to deal with this complex problem.
Clinical Diagnosis and Treatment Analysis of 16 Cases of Gastric-Type Endocervical Adenocarcinoma
Authors: Wei Mingzhou , Zhang Tianyue , Zhu Zhongyi , Zhang Yijing , Liu Yanhua , Duan Ruiqi
Published: July 2022

Objective: Cervical cancer classification based on human papillomavirus (HPV) infection status is necessary, as the popularity of HPV vaccination is increasing. Hence, this study aimed to explore the clinicopathological features, diagnosis, treatment, and prognosis of gastric-type endocervical adenocarcinoma (GAS) in west China. Methods: We performed a retrospective analysis and follow-up of patients with GAS who were hospitalized in West China Second University Hospital, a tertiary care center in west China, between September 2019 and April 2021. Results: A total of 16 cases were pathologically diagnosed as GAS at the hospital, most of which had no specific clinical manifestations. Among the 16 cases, 3 cases were confirmed preoperatively. The occurrence of full-layer cervix stroma infiltration, lymphatic vessel infiltration, and lymph node metastasis were 87.5%, 100%, and 50%, respectively. Among all cases, 8 cases were classified as stage III according to the International Federation of Gynecology and Obstetrics 2018 Clinical Staging Standard for cervical cancer. A total of 15 patients underwent a transabdominal or laparoscopic extensive hysterectomy, and the remaining 1 patient was pathologically diagnosed with GAS after a total hysterectomy and afterward underwent bilateral oophorectomy and pelvic lymph node dissection as supplementary surgeries. The follow-up data presented the survival of the 16 patients receiving concurrent chemoradiotherapy after surgery. However, GAS recurred in 3 non-medically-controlled patients among the 16 patients in 3 to 6 months after the treatment. Conclusions: GAS is a rare but highly malignant cancer that usually results in a poor prognosis. A few reports of GAS diagnosis and treatment, especially from developing countries, are available. Hitherto clinical routine screening methods might be insufficient to fulfill the requirements of GAS diagnosis owing to the difficulties in preoperative diagnosis and the probability of misdiagnosis. To reduce the rate of misdiagnosis, repeated deep multisite biopsies, cervical curettage, cervical conization, and hysteroscopy might be helpful in suspicious GAS cases.
Lactate Dehydrogenase-Inhibitors Isolated from Ethyl Acetate Extract of Selaginella doederleinii by Using a Rapid Screening Method with Enzyme-Immobilized Magnetic Nanoparticles
Authors: Zhang Feng , Li Huiyun , Liu Chao , Fang Kun , Jiang Yongmei , Wu Mingjiang , Xiao Shiji , Zhu Lei , Yu Jiaqi , Li Shenge , Wang Gang
Published: July 2022

Background: Lactate dehydrogenase (LDH) is one of the important enzyme systems for glycolysis and gluconeogenesis. It can catalyze the reduction and oxidation reaction between propionic acid and L-lactic acid, which is usually overexpressed in cancer cells. Therefore, inhibiting the activity of LDH is a promising way for the treatment of cancer. In this study, an effective method based on ligand fishing and ultra performance liquid chromatography-mass spectrum (UPLC-MS) was established to screen and identify active ingredients from Selaginella doederleinii with potential inhibitory activity for LDH. Methods: Firstly, LDH was immobilized on the magnetic nanoparticles (MNPs), three immobilization parameters including LDH concentration, immobilization time and pH were optimized by single factor and response surface methodology for maximum (max) immobilization yield. Then, a mixed model of galloflavin and chlorogenic acid (inhibitors and non-inhibitors of LDH) was used to verify the specificity of immobilized LDH ligand fishing, and the conditions of ligand fishing were further optimized. Finally, combined with UPLC-MS, immobilized LDH was used to simultaneously screen and identify potential LDH inhibitors from the ethyl acetate extract of Selaginella doederleinii. Results: The prepared fishing material was comprehensively characterized by scanning electron microscopy (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD) and fourier transform infrared spectrometer (FT-IR). The optimal immobilization conditions were obtained as LDH concentration of 0.7 mg/mL, pH value of 4.5, and immobilization time of 3.5 h. Under these conditions, the max immobilization yield was (3.79 ± 0.08) × 103 U/g. The specificity analysis showed that immobilized LDH could recognize and capture ligands, and the optimal ligand fishing conditions included that the incubation time was 30 min, the elution time was 20 min, and the concentration of methanol as eluent was 80%. Finally, two LDH inhibitors, amentoflavone and robustaflavone, were screened by immobilized LDH from the ethyl acetate extract of Selaginella doederleinii. Conclusions: The study provided a meaningful evidence for discovering the bioactive constituents in ethyl acetate extract of Selaginella doederleinii related to cancer treatment, and this ligand fishing method was feasible for screening enzyme inhibitors from similar complex mixtures.
Cellular Respiration in Thymic Fragments from Mice
Authors: Alshamsi Mariam , Hassane Maya , Almarzooqi Farida , Souid Abdul-Kader
Published: July 2022

Background: This report aims to detail the use of the phosphorescence oxygen analyzer for in vitro investigation of thymic responses to pharmaceutical agents, in particular immunosuppressants and immunomodulators. Sirolimus (a highly specific inhibitor of the ‘molecular target of rapamycin’, mTOR) and ozanimod (an agonist of the sphingosine 1-phosphate receptor, recently approved for treatment of multiple sclerosis and ulcerative colitis) are used for this purpose. Methods: Thymic fragments from mice were placed in glass vials containing phosphate-buffered saline, bovine albumin, and Pd(II) meso-tetra (sulfophenyl) tetrabenzoporphyrin. The vials were sealed from air, and the cellular oxygen consumption was monitored as function of time. Results: The decline of dissolved oxygen concentration with time (d[O2]/dt) was linear; thus, its rate (thymocyte respiration) was expressed as μM O2 min-1. Cyanide inhibited respiration, confirming the oxygen consumption was in cytochrome oxidase. In age-matched mice, the rate of thymocyte respiration (mean ± SD, in μM O2 min-1 mg-1) was 0.046 ± 0.011 (median = 0.043, range = 0.028 to 0.062, n = 10). In thymic fragments from littermates, this rate was inhibited in the presence of sirolimus (16% lower) or ozanimod (29% lower). Conclusions: Thymocyte respiration can serve as a surrogate biomarker for studying the mode-of-action and the cytotoxicity of immunotoxins and immunosuppressants.
Association of Diligence and Sociability with Stroke: A UK Biobank Study on Personality Proxies
Authors: Ruijter Markus J. T. de , Dahlén Amelia D. , Rukh Gull , Schiöth Helgi B.
Published: July 2022

Background: There is a growing interest in how personality may be related to the risk of developing disease. Associations between personality and stroke have so far only been studied in relation to stroke mortality. However, many stroke survivors suffer severe impairment of quality of life due to sequelae such as aphasia, hemiparesis, depression and anxiety. In this study we assess the association between personality and risk of stroke, regardless of mortality. Methods: Using self-reported data on psychological factors, mental health and social support, proxies for the Big Five personality traits were developed for 482,535 participants in the UK Biobank. Logistic regression and Cox proportional hazard models, with 95% confidence intervals (CI), were used to estimate odds ratios (OR) and hazard ratios (HR) between each personality trait and stroke prevalence (N = 6793) and incidence (N = 3312), respectively. Models were adjusted for demographic, health-related, and lifestyle factors. Results: Diligence and sociability were associated with a lower risk of stroke incidence in the fully adjusted model (respectively: [HR = 0.92; 95% CI = (0.88, 0.96)], [HR = 0.93; 95% CI = (0.89, 0.97)]). However, nervousness, curiosity and warmth were not significantly associated with a risk of stroke incidence. Conclusions: Individuals with higher levels of diligence and sociability may be at a reduced risk of developing stroke. With respect to the debated role of neuroticism in relation to cardiovascular disease, we did not find evidence of an association between nervousness and risk of developing stroke.
Circulating Inflammatory Mediators and Genetic Polymorphisms of Inflammation Mediators and Their Association with Factors Related to Abdominal Aortic Aneurysm: A Systemic Review and Meta-Analysis
Authors: Wang Hecheng , Zhong Zhenwu , Jiang Deying , Zhang Hao , Yin Fanxing , Guo Panpan , Chen Junyu , Zhu Xinyu , You Kui , Han Yanshuo , Liu Kun
Published: July 2022

Background: This study aimed to explore the levels of circulating inflammatory factors CRP, IL-6, IL-10 and TNF-α based on the literature review. This study also examined the influence of single nucleotide polymorphism (SNP) sites on the susceptibility of abdominal aortic aneurysm (AAA) using meta-analysis and intended to provide additional information on pathogenesis of AAA research. Methods: Electronic databases including PubMed and Web of Science were systemically searched to collect the information on AAA, inflammatory factors such as CRP, IL-6, IL-10, TNF-α and the SNP sites for data extraction. Altogether six SNPs in four genes (rs3091244, CRP; rs1800947, CRP; rs1205, CRP; rs1800795, IL-6; rs1800896, IL-10; and rs1800629, TNF) were assessed. Results: This study enrolled altogether 41 relevant investigations involving 9,007 AAA patients to carry out meta-analysis. According to pooled analysis, circulating CRP and IL-6 levels were shown to be related to the AAA, while plasma IL-10 and TNF-α levels were not associated with AAA. The circulating CRP level standard mean difference (SMD) was 0.30 (95% confidence interval (CI): 0.17–0.43), the IL-6 level SMD was 0.34 (95% CI: 0.20–0.49), the IL-10 level SMD was –0.01 (95% CI: –0.09–0.06), and the TNF-α level SMD was 0.09 (95% CI: 0.00–0.19). Similarly, the odds ratio (OR) of rs3091244 (CRP) under the recessive gene model was 1.70 (95% CI: 1.13–2.57). In addition, individuals with A and T mutant genes at locus rs3091244 might have a higher tendency of AAA susceptibility than those with C allele. Consecutively, the OR was 0.91 (95% CI: 0.51–0.97) for rs1800795 (IL-6) locus in the allele model, and individuals with G mutant gene at locus rs1800795 (IL-6) might be less susceptible to AAA than those with C allele. Meanwhile, the rs1800896 (IL-10) locus had a positive association under the five statistical models, and individuals with A mutant gene at locus rs1800896 might have a higher susceptibility to AAA than those with G allele. Nevertheless, the rs1800947 (CRP), rs1205 (CRP), and rs1800629 (TNF) loci did not have positive correlation under the five statistical models, with no statistical significance. The results indicate that the gene polymorphisms at rs1800629, rs1800947, and rs1205 loci were not related to the AAA susceptibility. Conclusions: Gene polymorphisms in certain known inflammatory mediators related to AAA susceptibility might serve as potential predictive biomarkers for clinical applications. Moreover, SNP of inflammatory mediators relevant to abdominal aortic aneurysmal formation and progression need extensive investigations to confirm these results.
Physical Activity and Exercise for Cardiorespiratory Health and Fitness in Chronic Kidney Disease
Authors: Gollie Jared M. , Cohen Scott D. , Patel Samir S.
Published: July 2022

Chronic kidney disease (CKD) is associated with an increased risk for cardiovascular disease (CVD), major adverse CVD events, and cardiovascular mortality. Low levels of physical activity and reduced cardiorespiratory fitness further compound the health consequences in this patient population. Aerobic exercise alone and the combination of aerobic and resistance exercise have beneficial effects for improving aerobic capacity while resistance exercise alone improves strength and skeletal muscle health. Given the prevalence of CVD in CKD patients and limited treatment options targeting traditional and non-traditional CVD risk factors in this population, the incoroporation of physical activity and exercise into the care of CKD seems critical for improving patient outcomes. Therefore, the purpose of this narrative review is to discuss the evidence of physical activity and exercise in CKD patients and the effects on cardiovascular outcomes and fitness.
Biological Surgical Options in Young Patients for the Treatment of Severe Aortic Stenosis: Is the Jury Still Out? A Review
Authors: Khalil Khalil , Forcillo Jessica
Published: July 2022

Aortic interventions remain the most effective treatment for severe aortic stenosis. In the recent years, advances in bioprosthetics and newer data have reduced the cut-off age for the use of bioprosthetic valves in younger patients, but the debate on whether to favor mechanical valves in younger patients remains a constant, especially with the undesired effects and considerations of anticoagulation therapy with vitamin K antagonists in this age group. Other options like the Ross procedure are gaining traction, despite still being undervalued and necessitating expertise centers. Hemodynamic considerations and durability of these options are important to consider, especially in this age group. Regardless of the choice of the prosthesis, patient informed consent is paramount since the decision affects the lifetime management of their initial condition, and expectations given must remain realistic.
Legal Politics Village Government Policies in Organizing Village-Owned Enterprises Based on Creative Economy
Authors: Putra Bayu Mogana , Erlangga Ridwan Adnan
Published: July 2022

The development of the creative economy continues to experience high productivity. It must be well adopted by creative economic actors, not least by a government-owned enterprise with very potential, namely the Village Owned Enterprise. This scientific paper aims to analyze and reveal the legal politics of village government policies in implementing Village Owned Enterprises based on a creative economy to improve the local economy by utilizing regional potential. The method used was a normative legal research method, namely by examining the concept of law as a principle of justice in the moral system and as a rule in legislation under the research focus in this scientific paper. The analysis in this scientific paper used three research approaches, namely the philosophical approach, the legislative approach, and the conceptual approach. In the end, the analysis and research revealed the ideal political-legal policy direction to be implemented by the village government in the implementation of a creative economy-based Business Entity by utilizing local potential to be developed and managed to create a productive and innovative economic activity. Therefore, it could support the improvement of the community's economy.
Descriptive Study of Advertising Message Strategy of Barista Special Blend by Top Coffee
Authors: Rasyid Mohammad Ichsan
Published: July 2022

Since 2017, For five consecutive years, Kopi Kapal Api has been the leading brand in Indonesia’s Top Brand chart in the instant roast and ground coffee category. The brand tagline, “Jelas Lebih Enak”, communicates the brand promise to deliver better taste, and has become one of the popular taglines among Indonesian consumers. Any coffee brand that wants to be perceived to be more excellent than Kopi Kapal Api needs to apply a distinguished Advertising Message Strategy to challenge the competition’s position. Therefore, this study aims to understand the distinguished applied Advertising Message Strategy by the newborn brand owned by an Indonesian Consumer Goods company, Barista Special Blend by Top Coffee. This study utilized The Elaboration Likelihood Theory Model as the analysis framework. This qualitative descriptive research collects data from literature studies and audiovisual advertising material from the official YouTube account of Top Coffee. The findings show that Barista Special Blend by Top Coffee endeavors to build a ‘Coffee Expert’ Brand Association and elaborate aesthetically on the process of serving a sophisticated Coffee-Making process made by the Barista Character. The study concludes that the Ad mainly uses the peripheral route to create expertise perception as the message strategy.
Initiating a National Criminal Law Profile in the Future in Indonesia
Authors: Hamzani Achmad Irwan , Mukhidin
Published: July 2022

The Indonesian nation does not yet have its product national criminal system. The current national criminal law system is the legal system left by the Dutch colonialists. The national criminal law system must be built based on the ideals of the nation contained in the Preamble to the 1945 Constitution. The research aims to formulate a future profile of national criminal law in Indonesia. This research uses a philosophical approach, which is to analyze the ideal law in the future. Data were analyzed qualitatively. The results of this study indicate the existence of criminal law in society as crime prevention through criminal law laws. Criminal law has a repressive and preventive function. Criminal law is part of the overall law that applies in a country in implementing criminal provisions. The Indonesian nation needs its own national criminal law system. The national criminal law is a criminal law based on Pancasila and the 1945 Constitution which applies nationally in Indonesia. Having its national criminal law for the Indonesian people is an effort to reveal national identity by the hopes and ideals of the independence of the Indonesian nation. The national criminal law profile ideally is the ideal of Pancasila law which is the perspective of the Indonesian people and places the bonds of togetherness and kinship ties as the core of the social life of the Indonesian people. The national criminal law system must be oriented to three pillars, namely: oriented to the values of “God”; oriented to the values of “Humanity”; and oriented to “Society” values.
Differential expression of ERRB3 in cancers of the breast.
Authors: Mamoor Shahan
Published: July 2022

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of women with breast cancer. We found significant differential expression of the gene encoding human epidermal growth factor receptor 3, ERRB3 (HER3), when comparing primary tumors of the breast to the tissue of origin, the normal breast: in women aged 70 and higher, and in women aged 45 and younger. ERRB3 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ERRB3 in primary tumors of the breast was correlated with overall survival in patients with breast cancer, but not in any specific PAM50 molecular subtype. ERRB3 may be of relevance to initiation, maintenance or progression of cancers of the female breast.
Tại sao các quốc gia áp dụng các biện pháp thuế quan?
Authors: Chân Trần Văn
Published: July 2022

Các quốc gia trên thế giới, khi tham gia vào hoạt động giao thương quốc tế, đều phải công khai biểu thuế quan – trong đó, quy định một cách có hệ thống các mức thuế quan đối với hàng hóa nhập khẩu, phương pháp tính thuế và cách thức thu thuế. Đây là căn cứ để các quốc gia thực hiện các biện pháp thuế quan, do vậy, các biện pháp thuế quan cũng chính là các công cụ minh bạch nhất trong chính sách thương mại của mỗi nước. Câu hỏi đặt ra, vậy tại sao các quốc gia áp dụng các biện pháp thuế quan?
Economic Efficiency
Authors: Cranier Louis
Published: July 2022

In microeconomics, economic efficiency, depending on the context, is usually one of the following two related concepts: Allocative or Pareto efficiency: any changes made to assist one person would harm another. Productive efficiency: no additional output of one good can be obtained without decreasing the output of another good, and production proceeds at the lowest possible average total cost.
Psychological Stress
Authors: Cranier Louis
Published: July 2022

In psychology, stress is a feeling of emotional strain and pressure. Stress is a type of psychological pain. Small amounts of stress may be beneficial, as it can improve athletic performance, motivation, and reaction to the environment.