bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of IGF-1 C472T, GH C2141G, and GHR T914A polymorphisms on growth performance and feed efficiency in young Kazakh white-headed cattle
Authors: Gerasimov Nikolay P. , Dzhulamanov K. M. , Lebedev S. V. , Kolpakov V. I.
Published: August 2023

Background and Aim: Improving the feed efficiency of beef cattle is necessary to increase the profitability of meat production. Implementing marker-assisted selection breeding systems can improve the genetic potential of beef cattle for increased productivity. This research aimed to study the effects of insulin-like growth factor (IGF)-1 C472T, growth hormone (GH) C2141G, and GH receptor (GHR) T914A polymorphisms on growth performance and feed efficiency in young Kazakh white-headed cattle.

Materials and Methods: Young Kazakh white-headed cattle (n = 50) were grouped after weaning according to sex (28 bulls and 22 heifers) and they were genotyped according to the IGF-1 C472T, GH C2141G, and GHR T914A polymorphisms. The test period was conducted from 8 to 15 months of age. The experimental animals were evaluated for live weight (LW) at the beginning and end of the test period. They were also assessed for average daily gain, hip height, metabolic mid-weight (MMWT), actual dry matter intake (DMI), and residual feed intake (RFI).

Results: Significant differences in MMWT were found between the bulls with the IGF-1TT and IGF-1CT genotypes, which was a 2.2 kg increase in heterozygous cattle (p < 0.05). Heterozygous IGF-1CT bulls differed with a higher DMI of 0.087 kg/ day (p < 0.05) compared to IGF-1TT homozygotes. Carriers of the IGF-1TT genotype had the greatest feed efficiency at 0.068 kg/day (p < 0.05). Heifers with the GHCC genotype differed in their maximum DMI with an increase of 1.17%–1.57% (p < 0.05) relative to the other genotypes. The G allele in the GH C2141G polymorphism was associated with better (p < 0.05) feed efficiency in the Kazakh white-headed breed. The minimum DMI and RFI in GHR T914A heterozygous heifers were significantly inferior (p < 0.05) to the other genotypes.

Conclusion: Association studies of the IGF-1 C472T, GH C2141G, and GHR T914A polymorphisms indicate a relationship between growth, development, and feed efficiency with the genetic characteristics of young Kazakh white-headed cattle. A significant (p < 0.05) dominant effect was found in the IGF-1 gene in bulls and in the GHR gene in heifers, which should be considered when breeding with heterogeneous parental pairs. The negative effect of the allele substitution in the IGF-1 C472T polymorphism was observed in the LW of heifers (−3.25 kg) at the age of 8 months and bulls (−6.05 kg) at 15 months. The substitution in the GH C2141G polymorphism was associated with a significant reduction in DMI by 0.036 kg (p < 0.05) and an increase in feed efficiency by 0.023 kg (p < 0.05) during the rearing of heifers. These results can improve the production efficiency of mature herds of Kazakh white-headed cattle.

Keywords: feed efficiency, growth hormone gene, growth hormone receptor gene, insulin-like growth factor-1 gene, Kazakh white-headed breed, polymorphism.
“AS ESCREVIVÊNCIAS” DE JOVENS ESCRITORAS ORIUNDAS DO ENSINO MÉDIO: um olhar sobre as práticas de letramento em um contexto de Escola Pública
Authors: Da Silva Franciane Barbosa
Published: August 2023

Este referido artigo tem por finalidade compreender as práticas de letramento como marcas identitárias  nas produções de jovens estudantes do Ensino Médio da Escola Pública Estadual. Para tanto, há uma  necessária contribuição teórica de pensadores que discutem práticas sociais de letramento Brian Street  (1970); O papel da escola no reflexo dessas práticas, Theodoro da Silva (1992); e Stuart Hall (1973)  que contribuem com as discussões sobre marcas identitárias; e Conceição Evaristo (2016) com a noção  de escrevivências. O percurso metodológico para se chegar aos resultados é de uma pesquisa  qualitativa do tipo bibliográfico, tendo como objeto de estudo uma produção desenvolvida por  estudantes do Ensino médio de Escola Pública, cujo título é: CONVERSA AFIADA: um lugar de  criação estudantil. Os resultados obtidos levam a uma reflexão de ampliar investigação de produções  que potencializam as produções de estudantes que escrevem com engajamento.
Diálogos fora da colonialidade: considerações sobre a educação para as relações étnico-raciais no Brasil
Authors: Fernandes Maria Aline
Published: August 2023

A partir das perspectivas decoloniais, este artigo objetiva analisar estratégias político-pedagógicas de descolonização de saberes, compreender como as ideologias constitutivas da colonização atuam na educação escolar e, assim, apontar algumas possibilidades para a educação das relações étnico-raciais no Brasil. Em primeiro lugar, analisa-se como o capitalismo subordina a educação globalmente. Em seguida, demonstram-se os vínculos entre a difusão dos conhecimentos, a dominação colonial e os efeitos para a elaboração dos currículos escolares. Por fim, evidencia-se que para além das expressões dos projetos modernos e coloniais há outras marcas impressas em todas as manifestações ditas brasileiras e que essas devem constituir-se como bases para se construírem outras pedagogias.
De atelierista a cartógrafo: deslocamentos e entrelaces no papel do professor de arte na educação infantil
Authors: Espadaro Grande Nataly
Published: August 2023

O presente artigo investiga as concepções instrucionista e espontaneísta no ensino de arte, refletindo acerca da origem de práticas comuns na educação infantil. Aborda o ateliê como espaço potente para a experiência com a arte, a partir de conceitos da abordagem de Reggio Emilia. Tem como objetivo compreender os deslocamentos no papel do professor de arte trazidos pela figura do atelierista no entrelace com a cartografia e com a documentação pedagógica.
O FRACASSO ESCOLAR EM PESQUISAS ACADÊMICAS NA ATUALIDADE
Authors: Voltas Fernanda Quatorze , De Castro Neto Antonio Francisco , Néris Sabino Bianca Luiza , Dos Santos Tayná Cassaro
Published: August 2023

Esse estudo, de abordagem qualitativa, analisou concepções de fracasso escolar e proposições práticas para o seu enfrentamento, presentes em trabalhos acadêmicos da área da Educação. O referencial teórico contou com os aportes de Maria H. Patto (1999), Paulo Freire (1987) e Pierre Bourdieu (1992). A investigação permitiu concluir que, na atualidade, o fracasso escolar tende a ser discutido, em nível da teoria, a partir de uma visão mais ampla, que busca contextualizar e evidenciar os múltiplos fatores de sua produção. Isso parece indicar um avanço, uma vez que supera concepções anteriores fragmentadas e focalistas. Os achados reafirmam a necessidade de buscar alternativas teórico-práticas que potencializem a garantia do direito ao acesso e permanência à uma educação com qualidade social.
ARTE, ESTÉTICA E DOCÊNCIA: CAMINHOS POSSÍVEIS PARA DIALOGAR COM AS INFÂNCIAS
Authors: Americano Mariana , De Araujo Silva Jeane
Published: August 2023

O presente trabalho é um relato de experiência de duas educadoras que atuam com crianças em contextos e espaços diferentes: uma, professora num grupamento de crianças entre 3 e 4 anos, na cidade do Rio de Janeiro; outra, formadora de educadores da Educação Infantil na rede municipal de São Paulo, membro da Associação Pikler e educadora de bebês, propondo vivências com inspirações na arte contemporânea. Nosso objetivo com este relato é provocar o leitor a refletir e reencontrar a potência da experiência estética em sua vida, aquela que traspassa o indivíduo e o toca (LAROSSA, 2002). Concordamos que, para estarmos com crianças, como educadoras que somos, uma nutrição estética do ser pode abrir espaços e caminhos para propostas que contemplem a sensibilidade, os afetos e a arte.
Arte, estética e docência: caminhos possíveis para dialogar com as infâncias.
Authors: Silva Jeane De Araujo , Americano Mariana
Published: August 2023

O presente artigo é fruto de uma reflexão a partir de referenciais teóricos que pensam as infâncias por meio da arte, da sensibilidade e de uma formação docente nutrida esteticamente. Resulta do diálogo de duas educadoras que atuam com crianças em contextos e espaços diferentes: uma, professora num grupamento de crianças entre 3 e 4 anos, na cidade do Rio de Janeiro; outra, formadora de educadores da Educação Infantil na rede municipal de São Paulo, membro da Associação Pikler e educadora de bebês, propondo vivências com inspirações na arte contemporânea.Nosso objetivo com este artigo é provocar o leitor a refletir e reencontrar a potência da experiência estética em sua vida, aquela que transpassa o indivíduo e o toca (LAROSSA, 2002). Concordamos que, para estarmos com crianças, como educadoras que somos, uma nutrição estética do ser pode abrir espaços e caminhos para propostas que contemplem a sensibilidade, os afetos e a arte.
Emerging Trends in Single-Use Technology in the Manufacturing of Antibody-Drug Conjugates
Authors:   MilliporeSigma, Green Karen , Robinette Mary ,   MilliporeSigma, Yao Gang ,   MilliporeSigma, Landry Nicholas ,   MilliporeSigma
Published: August 2023

Single-use technology, designed for the manufacturing of biopharmaceutical products, has made major inroads over the last 30 years. First introduced in the late 1970s in the form of disposable capsules and a range of filters, single-use technologies were revolutionized in the late 2000s with the introduction of single-use 2D and 3D process containers and filter assemblies for mixing and storage systems. Today, these technologies have been adopted across the upstream manufacturing process, downstream purification and fill-finish of entire classes of biologic drugs.
Struktur Komunitas Lamun di Pulau Sintok, Menjangan Besar dan Kemujan, Karimunjawa
Authors: Noor Yasmin , Trinuraini Ria Azizah , Riniatsih Ita
Published: August 2023

Taman Nasional Karimunjawa merupakan salah satu taman nasional yang memiliki kekayaan alam hayati yang sangat beranekaragam. Ekosistem padang lamun adalah salah satu ekosistem penting yang ada di laut dan memiliki banyak manfaat bagi keberlangsungan hidup biota laut. Penelitian ini bertujuan untuk mengetahui komposisi jenis, kerapatan lamun, persentase tutupan dan kualitas perairan di Pulau Sintok, Pulau Menjangan Besar dan Pelabuhan Legon Bajak. Pertumbuhan lamun sangat dipengaruhi oleh kualitas perairan disekitar ekosistem lamun. Perbedaan kualitas perairan diduga dapat mempengaruhi kondisi lamun di Pulau Sintok, Pulau Menjangan Besar dan Pelabuhan Legon Bajak. Metode pengamatan kondisi ekosistem lamun menggunakan metode line transek kuadrat. Metode analisis korelasi yang digunakan adalah analisis pearson correlation. Analisis hubungan kualitas perairan dengan kerapatan lamun di dapatkan nilai korelasi pada suhu sebesar -0.569, pada arus sebesar -0.216, pada kedalaman sebesar -0.706, pada pH sebesar -0.715, pada salinitas sebesar 0.715, pada nitrat  sebesar 0.136 dan pada fosfat sebesar 0.715. Berdasarkan hasil analisis variabel kedalaman, pH, salinitas, fosfat menunjukkan nilai korelasi yang kuat, variabel suhu menunjukan nilai korelasi yang cukup sedangkan variabel arus dan nitrat menunjukkan nilai korelasi lemah terhadap kerapatan lamun Karimunjawa National park are one of the national park which have a very diverse biological wealth. Seagrass ecosystem is one of the important ecosystems in the sea and has many benefits for the survival of marine life. This study aims to determine the species composition, seagrass density, cover percentage and  water quality in Sintok Island, Menjangan Besar Island and legon bajak harbor. The growth of seagrass is influenced strongly by the quality of the waters in the seagrass ecosystem. Differences in the quality of the waters are thought to affect the condition of seagrass on Sintok Island, Menjangan Besar Island and Legon Bajak Harbor. The method used to observe the condition of the seagrass ecosystem is seagrass-watch method. The correlation analysis method used is the regression analysis with correlation test. Analysis of the relationship of water quality with seagrass density indicated a correlation value at -0.569 temperature, at -0.216 current, at -0.706 depth, -0.715 pH, at 0.715 salinity, at 0.136nitrates, at 0.715phosphates. From this study, it can be concluded that the quality of the waters on Sintok Island, Menjangan Besar Island and Legon Bajak Harbor has a strong relationship in temperature, nitrate in water, nitrate phosphate in sediment, strong correlation relationship in current, medium correlation relationship at depth, pH, salinity, phosphate in water to seagrass density.
Hubungan Tekstur Sedimen Terhadap Vegetasi Mangrove Di Desa Pasar Banggi, Kabupaten Rembang
Authors: Ardang Devtiana Marchelia , Soenardjo Nirwani , Taufiq-SPJ Nur
Published: August 2023

Mangrove merupakan vegetasi yang tumbuh diantara garis pantai dan dipengaruhi oleh pasang surut. Pertumbuhan ekosistem mangrove dapat dilihat melalui ukuran butir sedimen yaitu lumpur, liat dan pasir. Penelitian ini bertujuan untuk mengetahui hubungan tekstur sedimen terhadap mangrove di pantai utara Rembang. Metode kuantitatif diterapkan pada penelitian ini, pengambilan sampel didapat dari hutan mangrove Pasar banggi Kabupaten Rembang. Sampel sedimen dan data analisa vegetasi mangrove diambil dari 3 stasiun yang terbagi dalam 3 wilayah yaitu aliran sungai, daerah ekowisata dan daerah tambak garam. Hasil yang diperoleh dari tekstur sedimen di Desa Pasar Banggi didominasi oleh lumpur (28,48-49,3%), pasir (30,7-63,76) dan liat (0-18). Hasil penelitian menunjukkan bahwa kondisi kawasan mangrove di desa Pasar banggi termasuk padat karena memiliki nilai kategori kerapatan berkisar 1496,29-4266,67 ind/ha (KepMen LH NO. 21, 2004). Hasil uji regresi linier berganda menunjukkan bahwa hubungan antara tekstur sedimen dengan kerapatan mangrove pada PB1 (kerapatan rapat) mempunyai hubungan rendah dengan koefisien korelasi (R) 0,225; PB2 (kerapatan rapat) mempunyai hubungan yang sangat kuat dengan koefisien korelasi (R) 0,942; PB3 (kerapatan sedang) mempunyai hubungan sangat kuat dengan koefisien korelasi 0,999. Mangroves are vegetation that grows between shorelines and is influenced by tides. The growth of the mangrove ecosystem can be seen through the grain size of the sediment, namely mud, clay and sand. This study aims to determine the relationship between sediment texture and mangroves on the north coast of Rembang. Quantitative methods were applied in this study, sampling was obtained from the mangrove forest of Pasar Banggi, Rembang Regency. Sediment samples and mangrove vegetation analysis data were taken from 3 stations which were divided into 3 areas, namely river flows, ecotourism areas and salt pond areas. The results obtained from the sediment texture in Pasar Banggi Village are dominated by mud (28.48-49.3%), sand (30.7-63.76) and clay (0-18). The results showed that the condition of the mangrove area in Pasar Banggi village was dense because it had a density category value ranging from 1496.29 to 4266.67 ind/ha (KepMen LH NO. 21, 2004). The results of multiple linear regression test showed that the relationship between sediment texture and mangrove density in PB1 (density) had a low relationship with a correlation coefficient (R) of 0.225; PB2 (density) has a very strong relationship with a correlation coefficient (R) of 0.942; PB3 (medium density) has a very strong relationship with a correlation coefficient of 0.999.
Analisis Nilai Estetika Pulau Gili Labak Kabupaten Sumenep Dengan Metode Scenic Beauty Estimation (SBE)
Authors: Wahyudi Ach , Rini Dyah Ayu Sulistyo , Muhsoni Firman Farid
Published: August 2023

Keanekaragaman hayati laut dan kepulauan mempunyai daya tarik wisata yang potensial untuk dikembangkan. Pulau kecil dengan kondisi terumbu karang yang baik menjadi obyek wisata yang sangat diminati.Tujuan penelitian ini adalah mengetahui kondisi terumbu karang dan evaluasi keindahan Pulau Gili Labak Sumenep.Metode pengukuran terumbu karang menggunakan metode LIT (Line Intercept Transect) dan Metode Scenic Beauty Estimation (SBE) digunakan untuk menilai dan menganalisis kualitas pemandangan lanskap. Metode ini menggunakan kuisioner berisi dokumentasi (foto lokasi) dengan foto lokasi pembanding (Pulau Gili Trawangan sebagai pembanding).Hasil penelitian menunjukkan karang hidup 63,1%, karang mati 33,1%, fauna lain 0,6%, algae 3,61% dan abiotik 2,6%.  Rasio kematian karang (Indeks mortalitas) masuk dalam kategori sedang (0,35). Hasil analisa SBE menunjukkan dari 15 foto yang dibandingkan ada 5 foto yang nilainya positif dan 10 foto yang nilainya negatif.Hal ini menunjukkan ada 5 lokasi lanskap yang lebih baik di Pulau Gili Labak, dan ada 10 lokasi lanskap yang lebih baik di lokasi pembanding. Nilai terendah terdapat -8.36 pada foto lanskap 13 dan nilai tertinggi  6,26 pada foto lanskap 3. Pada kawasan yang memiliki nilai yang rendah perlu dilakukan perlakukan khusus untuk meningkatkan nilai lanksap.Fasilitas yang kurang menarik menjadikan alasan beberapa foto lanskap menjadi rendah, perlu pengembangan fasilitas untuk menunjang kepuasan pengunjung. Marine biodiversity and archipelagic have a potential tourist attraction to be developed. Small island with good Coral reef condition are very popular tourist attractions. The purpose of this study is to determine the condition of Coral reefs condition and evaluate the beauty of Gili Labak Island, Sumenep. The method of Coral reef measurement uses LIT (Line Intercept Transect) method and the Scenic Beauty Estimation (SBE) method is used to assess and analyze the quality of landscape views. This method uses a questionnaire containing documentation (location photos) with photos of comparison location (Gili Trawangan Island as comparison) athe results showed live coral 63.1%, dead coral 33.1%, other fauna 0.6%, algae 3.61%, and abiotic 2.6%. Coral mortality ratio (mortality index) is in the moderate category (0.35). The results of SBE Analysis showed that from 15 photos that were compared, there were 5 photos with positive values and 10 photos with negative values. This shows that there are 5 better landscape locations on Gili Labak Island, and there are 10 better landscape locations on the comparison location. The lowest value is -8.36 for landscape photos 13 and the highest value is 6.26 for landscape photos 3. In areas with low values, special treatment is needed to increase the landscape value. Unattractive facilities are the reason why some landscape photos are low, it is necessary to develop facilities to support visitor satisfaction.
Penyerapan Karbon Pada Vegetasi Lamun Di Pantai Legon Bajak Pulau Kemujan, Taman Nasional Karimunjawa
Authors: Rahmadanti Karla Lutfia , Santosa Gunawan Widi , Pramesti Rini
Published: August 2023

Gas karbondioksida yang tinggi di atmosfer dapat memicu pemanasan global. Upaya mitigasi diperlukan untuk mengurangi dampak buruk, salah satunya dengan pemanfaatan lamun sebagai penyerap karbon yang dikenal dengan  blue carbon. Penelitian ini bertujuan mengetahui estimasi biomassa dan kandungan karbon pada vegetasi lamun di Pantai Legon Bajak Pulau Kemujan, Taman Nasional Karimunjawa. Penelitian dilakukan pada 28 – 29 November 2021 dengan dua stasiun. Analisis vegetasi dilakukan menggunakan metode line transect quadrant, yang mengacu pada buku Panduan Monitoring Padang Lamun LIPI. Pengambilan sampel lamun menggunakan seagrass core. Biomassa lamun terbagi menjadi bagian atas substrat (daun) dan bawah substrat (akar dan rhizoma). Nilai biomassa lamun ditentukan melalui berat kering dari dengan cara pengeringan. Nilai kandungan karbon diperoleh melalui metode LOI (Loss of Ignition) atau pengabuan kering.Hasil penelitian diperoleh 5 jenis lamun, antara lain Enhalus acoroides, Thalassia hemprichii, Cymodocea rotundata, Halophila ovalis dan Halodule uninervis. Kondisi padang lamun tergolong memiliki penutupan sedang. Nilai biomassa yang terdapat di bawah substrat (585 g/m2) lebih besar dibandingkan yang terdapat di atas substrat (346,73 g/m2), diikuti dengan kandungan karbon di bawah substrat (182,54 gC/m2)yang lebih besar dibandingkan atas substrat (119,43 gC/m2). Vegetasi lamun di lokasi penelitian berpotensi menyimpan karbon sebesar 301,97 gC/ m2. The high level of carbondioxide gas in the atmosphere can trigger global warming. Mitigation efforts are needed to reduce adverse impacts, such as by the optimization of seagrass as a carbon sink which is known as blue carbon. This study aims to determine the estimation of biomass and carbon content in seagrass vegetation at Legon Bajak Beach, Kemujan Island, Karimunjawa National Park. The research was conducted on 28 – 29 November 2021 at two stations. Vegetation analysis was conducted by using the line transect quadrant method, which refers to the LIPI Seagrass Monitoring Guidebook. Seagrass sample was collected by using seagrass core. Seagrass biomass is divided into above substrate (leaves) and below substrate (roots and rhizomes). The value of seagrass biomass was determined through dry weight by drying process in the oven. The value of carbon content in seagrasses is obtained through the LOI (Loss of Ignition) method or dry ignition.The results o the study obtained 5 species of seagrasses, including E. acoroides, T. hemprichii, C. rotundata, H. ovalis and H. uninervis. The condition of seagrass meadows is classified as having moderate cover. The value of the biomass below substrate (585 g/m2) is greater than the value of biomass above the substrate (346.73 g/m2), followed by the value of carbon content below the substrate (182.54 gC/m2) which is greater than above substrate (119.43 gC/m2). Seagrass vegetation in the study site has the potential to store 301.97 gC/m2 of carbon.
ANALISA EFEKTIFITAS PADA OIL VOLUM LEVEL CONTROL (OVLC) OTOMATIS MENGGUNAKAN WEMOS MINI BERBASIS TELEMETRI DENGAN METODE OVERALL EQUIPMENT EFFECTIVENESS
Authors: Rofi'i Ahmad , Apriliandika Yuda Fiyan , Purnomo Fendik Eko
Published: August 2023

Tujuan penelitian dalam makalah ini adalah untuk menganalisis keefektifan alat Automatic Oil Volume Level Control (OVLC) menggunakan Wemos Mini Berbasis Telemetri. Metode analisis yang digunakan adalah metode efektivitas peralatan secara keseluruhan. Metode ini digunakan sebagai bagian yang dapat langsung mengidentifikasi masalah yang muncul sehingga perbaikan dapat dilakukan dengan cepat dan terfokus pada inti masalah. Parameter yang digunakan dalam menganalisis adalah tingkat ketersediaan, tingkat kinerja dan tingkat kualitas. OVLC otomatis menggunakan arduino wemos, wemos mini, bread board, sensor ultrasonik, kabel jumper dan handphone. Wemos mini sebagai mikrokontroler untuk sensor level volume oli peneliti menggunakan sensor Ultrasonic untuk mendeteksi pada oil pan jika terjadi kekurangan atau habis maka sensor akan memberikan sinyal yang akan diterima oleh controller. Sebagai keluaran akhir dari peralatan ini akan tertera apakah oli pada sepeda motor masih ada atau sudah habis yang akan ditampilkan pada handphone dengan menggunakan alat telemetri yaitu telegram. Dari data yang diperoleh bahwa tingkat ketersediaan selama proses penggunaan alat berkisar antara 85,71% - 97,14%. Tingkat Kinerja Parameter berkisar antara 62,61% hingga 80,00%. Hal ini berbanding terbalik dengan parameter availability rate yang berarti semakin lama down time maka semakin tinggi performance rate dan sebaliknya. Sedangkan tingkat kualitas parameter diperoleh antara 96,67% - 98,3%.
Consumer Trust as a Mediator of the Link Between Promotional Mix and Customer’s Decision to Use Cellular Phone Service
Authors: Al-Qadasi Ahmed , Karim Fazida
Published: August 2023

Customer’s (use) purchasing decision making have the crucial point of several marketing decision-makers in all type of businesses. Studies have suggested that ambiguity still exist in terms of variables capable of enhancing the indirect link between the promotional mix (PM) and customer’s purchasing (use) decision, specifically in the cellular communication sectors of most of the developing countries. This study is an attempt to explore the link between promotional mix (PM), consumer trust, and customer use decisions in the context of Yemen cellular communications sector. The hierarchy of effects theory is used as underlying theory, and quantitative cross-sectional survey method with questionnaire were used in collecting data. The random sampling method was used in distributing the questionnaire to 382 respondents . The Partial Least Squares Structural Equation Modelling (PLS-SEM) was used in analyzing the data. The result shows that promotional mix and customer trust has significant and positive  effect on customer use decisions, and customer trust mediate the link between promotion mix and customer use decisions. Finally, the study provided some useful suggestions for future studies.
Management Functions in an Organization PROMAG, Lda-Portus Hibericus
Authors: Ferreira Ana Beatriz , Lopes Ana Beatriz , Santos Ana Luisa , Pereira Adalmiro , Teixeira Tânia
Published: August 2023

PROMAG has, as its main objective, the production and export of olive oil and various products of Portuguese origin, hence our choice. We wanted to understand and explore how this whole process works, from the raw material to the final product. And then, where management is applied and how all the concepts discussed in the classroom work in practice. In the course of our analysis, we approach different points in the functioning of a company, starting with its birth and what motivated it; we talk a little about its social objective and the story behind the brand, how it all really started and developed. More at a technical level, we addressed the organizational structure – how responsibilities are divided, the leaders we have present; the planning phase and after that planning, the control that has to be applied to all the products that the brand produces and exports. In the final phase of the process, we will talk about how the company is marketed, how the final product is presented to the public and which products are available for sale. In order to be able to carry out a very complete work, we contacted the manager and partner of the company, Rui Pereira, who provided us with all our values ​​and answers to what the work asked of us.
Discuss: Several Problems in the Chinese Ancient History Textbook of Zhu Shaohou Version
Authors: Yao Jianguang , Chen Lingfei
Published: August 2023

The textbook Ancient History of China edited by Zhu Shaohou and others is the most widely used textbook for the course "Chinese ancient history" of history majors in Chinese universities. This textbook has been revised multiple times in the past 40 years, but there are still many problems, such as contradictory expressions of the same problem, lack of pronunciation and meaning labeling of rare characters in ancient literature, omission of legal and diplomatic aspects in the history of Song and Yuan , inaccurate use of historical materials, and obvious untrue statements; Part of the content is outdated, neglecting the important role of maps, schematics, datasheets, and physical photos in students' construction of specific historical time and space and understanding of relevant content. These issues reveal that there is room for improvement at all stages of the compilation process of undergraduate history textbooks in Chinese universities, and it is urgent to attract the attention of the historical community and management departments.
Influence of Residential Internet Access and Patented Innovation on U.S. Non-store Retail Industries’ Employment
Authors: Khan Abdullah
Published: August 2023

This paper studies employment trends of the U.S. nonstore retail industries at multi-jurisdictional levels (States, Census Regions, Census Division, and the nation) for years 2001 through 2021. The nonstore retail industry is a growing subsector of the overall retail industry. With  no or skeletal ‘brick- and-mortar presence’, nonstore retailers are poised for leveraging information and communication technologies and innovations from the inception of their business operations.  With the need for scaling up in the backdrop of limited or zero ‘on-site’ customer-interactions, the nonstore retailers are inclined to find novel ways to  interact and transact with existing and prospective customers. As more and more brick-and-mortar stores begin to offer electronic shopping opportunities from their web-based stores, traditional nonstore retailers face steeper competition. Utilizing panel data regressions this paper explores marginal impacts of residential internet access,  patented innovations, and other fiscal and macroeconomic variables on  nonstore retail industry (NAICS Code 454). The regression results suggest that residential internet access is a positive influence on both nonstore retail employment and number of nonstore retail entities. The results also suggest that utility patents and design patents are positive factors for growth of nonstore retail industry’s employment and business entities.
Task-Based Needs Analysis: Identifying Gaps Between Cultivation Scheme of BE MA Program and Market Demands: A Case Study of GDUFS BE Program
Authors: Guangdong Yilin Xu
Published: August 2023

Cultivation scheme is the foundation of the teaching. With an increasing demand of professional English talents, needs analysis of market demands has become a significant basis for the development of Business English teaching. Despite the growing popularity of Business English (BE), needs analysis combining cultivation scheme and markets demands has rarely been carried out. Based on the the cultivation scheme of BE MA program of Guangdong University of Foreign Studies (GDUFS) and wants ads collected online, this study aims to identify gaps between the cultivation scheme and market demands in Guangdong. Adopting the Key to employability Model and competence model, the present study investigates the following three questions: (1) what is the market demands for professional BE talents? (2) Is there a gaps between the overall cultivation scheme of BE MA programs in GDUFS and the market demands for BE talents? If there is a gaps, what’s the discrepancy between the cultivation scheme of BE MA program and the market demands and how to improve the current cultivation scheme? (3) How to realize the program mission of the modified cultivation scheme? The results reveal that objectives of GDUFS BE Postgraduates program cultivation scheme should be improved and can be modified according to the General Model of BE Postgraduates’ Abilities. Some practical suggestions regarding the revision and realization of the cultivation scheme of BE MA program of GDUFS are put forward. The research results have reference value for universities to adjust their orientations to meet the market demands.
Supporting first-year students in learning molecular orbital theory through a digital learning unit
Authors: Hauck David Johannes , Steffen Andreas , Melle Insa
Published: August 2023

A large number of chemistry students drop out of their studies, often because of high requirements for content knowledge. Quantum chemical models of atomic bonding such as molecular orbital (MO) theory are particularly challenging. We aimed to develop an intervention on MO theory based on the Computer-Supported Collaborative Learning framework. First, students work independently with interactive learning videos. Then, they create concept maps about core concepts of MO theory. In this paper, we present the evaluation of this intervention in terms of content knowledge, considering person-specific characteristics. Additionally, we compare three different treatment groups with varying materials and group arrangements, and prospective chemistry teachers with other first-year students. Our results show that students can answer single-choice questions well with the prior knowledge from their first-year chemistry course. Answering open-ended questions is more difficult. Nevertheless, they can improve significantly in both categories by working with the learning videos; creating concept maps does not lead to significant content knowledge changes. There are also no significant differences between the three treatment groups, or between teacher students and other chemistry freshmen. Regarding prior knowledge, differences depending on gender and school-leaving grades can be measured, whereas the choice of courses in school has no effect.
Lipid-based nanoparticles for cancer immunotherapy
Authors: Fan Shumin , Han Huize , Yan Zhicheng , Lu Yao , He Bing , Zhang Qiang
Published: August 2023

As the fourth most important cancer management strategy except surgery, chemotherapy and radiotherapy, cancer immunotherapy has been confirmed to elicit durable antitumor effects in the clinic by leveraging the patient’s own immune system to eradicate the cancer cells. However, the limited population of patients who benefit from the current immunotherapies and the immune related adverse events hinder its development. The immunosuppressive microenvironment is the main cause of the failure, which leads to cancer immune evasion and immunity cycle blockade. Encouragingly, nanotechnology has been engineered to enhance the efficacy and reduce off-target toxicity of their therapeutic cargos by spatiotemporally controlling the biodistribution and release kinetics. Among them, lipid-based nanoparticles are the first nanomedicines to make clinical translation, which are now established platforms for diverse areas. In this perspective, we discuss the available lipid-based nanoparticles in research and market here, then describe their application in cancer immunotherapy, with special emphasis on the T cells-activated and macrophages-targeted delivery system. Through perpetuating each step of cancer immunity cycle, lipid-based nanoparticles can reduce immunosuppression and promote drug delivery to trigger robust antitumor response.
Management of innovative projects on the basis of a system-oriented approach
Authors:   Lviv Polytechnic National University, Podolchak Nazar , Karkovska Veronika ,   Lviv Polytechnic National University, Levytska Yana ,   Lviv Polytechnic National University
Published: August 2023

This review article argues that a startup is the first necessary step in the innovation lifecycle and a set of tools is necessary to create a successful startup. In a practical section installed that the implementation startup involves several steps such as generalization of a startup concept, definition of the stages of the startup life cycle, systematization of key components of successfully implemented startups and analysis of the state of the domestic market of startups. The life cycles of well-known startups developed by Ukrainian experts show that it is necessary to find a suitable niche in the market with high demand for the product in order to turn startup into a profitable business. This is possible, provided an effective ecosystem for startups development.
“Las células se dibujan a mano alzada”. Construcción de contenidos biológicos en cursos digitales
Authors: Montero Vargas Rene , Zambrano Montilla Jeniffer
Published: August 2023

Objetivo: Este artículo de investigacion busca identificar formas en que sucede la construcción de  conocimientos biológicos entre estudiantes que desarrollan programas de formación en cursos digitales. Metodología: Se asume una  perspectiva etnográfica digital y de análisis del discurso sobre datos empíricos tomados directamente de los foros de trabajo de cada una de las actividades donde interactuaron los estudiantes y sus docentes. Resultados: Los análisis permiten señalar que la construcción disciplinar en el caso de los ambientes digitales se sustentó principalmente en reproducción de modelos, comparaciones y resolución de problemas, estrategias que se comparten con procesos educativos presenciales; lo cual da lugar a cuestionamientos frente al asumir el carácter innovador de los procesos educativos digitales por el solo uso de tecnologías. Conclusiones: En este estudio se resalta un llamado desde la investigación educativa a conitnuar indagando el aporte de la incorporación de tecnologías en procesos formativos frente al manejo disciplinar, aspecto que, desde la perspectiva de esta investigación, aún requiere mayores análisis.
Producción de video de divulgación científica como profundización de aula magistral en medicina
Authors: Triana Vidal Luz Elena , Suaza Frank , Jaramillo Diana , Guerrero Alejandro
Published: August 2023

Resume 

Objetivo general: El presente escrito pretende compartir dos experiencias, la primera en febrero del año 2019 y la segunda en junio de 2022; donde se articula la clase magistral, la resolución de problemas basado en evidencia y la elaboración de contenido audiovisual en torno al desarrollo de las siguientes preguntas ¿Por qué es tan difícil encontrar una vacuna en malaria? y ¿Qué síntomas son relevantes en el diagnóstico de enfermedades tropicales?

Metodología: La didáctica inicia con conceptos expuestos en clase magistral, planteamiento de manera grupal de una pregunta problema y resolución mediante evidencia bibliográfica, para finalmente ser divulgada como video en youtube o tick tock.

Resultados: En el año 2019, se divulgó el contenido audiovisual en el canal youtube, en el programa ¿sabías que? de la institución: https://youtu.be/Fno8xrEF-DY.En el año 2021, los estudiantes crearon y desarrollaron el video de tick tock https://www.tiktok.com/@medicinagrupoa1/video/7108368724423494918?is_from_webapp=1&sender_device=pc&web_id=7121711221762229765

Conclusiones: La elaboración del video permite que los estudiantes fortalezcan capacidades como: trabajo en equipo, toma de decisiones, análisis, síntesis y autocrítica; ya que deben evaluar los posibles perjuicios de utilizar vocabulario científico impreciso y reforzar continuamente los conceptos desarrollados en clase, para lograr sintetizar sus conocimientos y expresarlos en el breve tiempo que dura el video. 

Palabras clave: Enseñanza en medicina, pregunta problema, resolución basado en evidencia, video, tik tok, youtube, apropiación del conocimiento.
Traditions of the Production of Bast Shoes from the Mordovians
Authors: Kornishina Galina A.
Published: August 2023

Introduction. The article discusses the structure of the craft associated with the manufacture of bast shoes among the Mordovians in the late 19th – early 20th centuries. It is supposed to consider the level of development of this industry, to identify its quantitative and qualitative characteristics, sources of raw materials, as well as its significance for the traditional economy of Mordovians.

Materials and Methods. A comparative historical method was used, on the basis of which the forms of existence of individual components included in the structure of the fishery under consideration were studied, and the trends of changes occurring with it were traced. This method was applied in combination with the analysis of historiographic works and sources, as well as field research methods.

Results. Bast shoes among the Mordovians since ancient times were made mainly for the needs of their families. But by the end of the 19th century, this activity turned into handicraft production, which reached a significant size, although it was predominantly local in nature. It included not only the direct production of bast shoes (lapti, stupni), but also the tools used in the manufacture of products, the procurement and primary processing of raw materials – bast, the sale of finished products.

Discussion and Conclusion. The production of bast shoes among the Mordovians in the 19th and early 20th centuries remained mainly a household craft in which members of a peasant family were employed. At the beginning of the 20 th century, this industry began to decline. This was due to a decrease in forest area, which led to a shortage of raw materials, as well as low income from it. Bast shoes gradually began to go out of constant use, giving way to handicraft and factory leather shoes. Although, as everyday shoes, they continued to exist among the Mordovians until the middle of the last century.
Agriculture of Mordovia in the Conditions of Reforms of the Early 1990s
Authors: Mariskin Oleg I.
Published: August 2023

Introduction. The article examines the transformation of the agricultural industry in Russia during the transition to a market economy. The essence of the reforms consisted in a comprehensive change in the entire system of agrarian relations, including land ownership and other means of production, systems of farming and economic management, the transformation of the intersectoral and territorial structure of agro-industrial production, etc.

Results and Discussion. In order to form a new organizational and economic structure of the agricultural sector, at the end of 1991, the Government of the Russian Federation adopted regulations on the reorganization of collective farms and state farms and the procedure for the privatization of state agricultural enterprises. It was assumed that the arrays would be gradually withdrawn from collective and state farm land use in order to provide them to farmers without upper restrictions on the size of allotments.

By 1994, more than half of agricultural enterprises in Russia had chosen new organizational and legal forms of management, and preference was given to various types of partnerships. In Mordovia most enterprises in the agricultural sector have retained their former status as a collective farm or state farm.

The course of the ongoing reforms was accompanied by a decline in production, a decrease in livestock, the cost of agricultural products, sharp deterioration in the financial condition of agricultural enterprises. Even in these difficult years, when reforms were carried out inconsistently, and sometimes some attitudes contradicted others, part of the farms of Mordovia worked relatively steadily, made a profit, regularly paid salaries to employees, had a good profitability indicator.

Conclusion. As a result of the reorganization of collective agricultural enterprises, a significant step was taken towards the creation of a multi-layered agrarian economy based on equality of all forms of ownership and methods of land management. However, this did not bring tangible positive results in increasing the efficiency of agricultural production in the 1990s.
A dementia ellátása a háziorvosi gyakorlatban
Authors: Zsuffa János András , Kalabay László , Katz Sándor , Kamondi Anita , Csukly Gábor , Horváth András Attila
Published: August 2023

A dementiában szenvedő betegek kezelése, gondozása komplex feladat, amely az
egészségügyi alap- és szakellátás mellett a szociális ellátórendszer és a
szakápolási szolgálatok együttműködése által valósulhat meg. A háziorvos
kulcsszereplő a dementia kialakulásának megelőzésében, szűrésében, kezelésében
és gondozásában is. Célunk a korszerű dementiaellátás háziorvosi aspektusainak a
különféle prevenciós szinteken keresztül történő bemutatása. A páciensek
egészséges életmódra történő nevelése és cardiovascularis statusuknak
optimalizálása csökkenti a dementia kialakulásának esélyét. Kiemelten
foglalkoztunk a korai szűrés és szakorvoshoz utalás kérdésével, valamint a
korszerű ellátáshoz szükséges, idejében megkezdett, egyénre szabott terápia
fontosságával. A dementiával érintett betegek háziorvosi gondozásához
hozzátartozik a betegség lefolyásának követése mellett a társbetegségek
figyelemmel kísérése is, így a szövődmények csökkentésével mind a beteg, mind
családja életminősége javítható. A családorvosoknak fontos feladatuk a beteget
gondozó családtagok támogatása is. A jelenlegi magyarországi lehetőségek
bemutatása mellett a közleményhez áttekintettük a nemzetközi szakirodalmat és a
hazai szakmai irányelveket, amelyek folyamatos követése elengedhetetlen a
minőségi betegellátáshoz. Orv Hetil. 2023; 164(32): 1263–1270.
Cushing-szindrómát okozó macronodularis mellékvese-hyperplasia ARMC5-génmutáció következtében.
Authors: Hella Zoltán , Tőke Judit , Patócs Attila , Varga Zsolt , Dabasi Gabriella , Kovács Gábor László , Tóth Miklós
Published: August 2023

69 éves nőbetegünk kivizsgálása 2 év alatt bekövetkezett 20 kg testsúlygyarapodás
miatt kezdődött. Anamnézisében kezelt hypertonia, hyperuricaemia, kétoldali
cataractaműtét, mozgásszervi panaszok szerepeltek. Cukorbetegsége nem volt. A
fizikális vizsgálat során visceralis típusú elhízást, proximalis myopathiát,
illetve atrophiás, sérülékeny bőrt észleltünk, livid striát nem találtunk. A
rövid, kis adagú és a hosszú, kis adagú dexametazonszuppressziós tesztek autonóm
kortizol-túltermelést jeleztek (szérumkortizol: 172,6 és 153,2 nmol/l,
normálérték: <50 nmol/l). Az alacsony ACTH-szint (<1,11 pmol/l,
normáltartomány: 1,12–10,75 pmol/l) ACTH-independens hypercortisolismusra utalt.
A hasi CT-vizsgálat mindkét mellékvese macronodularis jellegű megnagyobbodását
írta le, a legnagyobb nodularis képlet jobb oldalon 23 × 20 mm, bal oldalon 24 ×
30 mm nagyságú volt (natív sorozaton –33 ± 37 HU denzitásértékekkel). A
131I-koleszterinnel végzett mellékvesekéreg-szcintigráfia és
SPECT/CT mindkét oldalon közel azonos intenzitású radiofarmakon-felvételt
igazolt. A klinikai eredmények alapján ACTH-independens hypercortisolismussal
társuló bilateralis macronodularis mellékvese-hyperplasiát véleményeztünk. A
beteg perifériás vérmintájának célzott DNS-szekvenálása az ’armadillo
repeat-containing 5’
(ARMC5-) gén új, c.1724del28 bp (g.31,476,067–31,476,094)
heterozigóta mutációját igazolta. A beteg mindkét gyermekének genetikai szűrése
megtörtént az ARMC5-mutáció irányában; a fiatalabb gyermekénél
ugyanezt a mutációt igazoltuk. Az ismertetett eset tudomásunk szerint az első,
Magyarországon diagnosztizált, csírasejtes ARMC5-mutáció
mellett észlelt ACTH-independens hypercortisolismussal társult primer
bilateralis macronodularis mellékvese-hyperplasia, amely két egymást követő
generációt is érintett. Orv Hetil. 2023; 164(32): 1271–1277.