bluuebunny/crossref_metadata_2025 huggingface dataset:
La contribución de las ferias comerciales a la marca ciudad:
Authors: Jonàs Cortés Josep , De San Eugenio Vela Jordi , Ginesta Portet Xavier
Published: July 2023

Las ferias comerciales pueden ayudar a las ciudades a diferenciarse porque ofrecen importantes posibilidades respecto a la relación, la promoción y el posicionamiento de la marca del territorio (de San Eugenio Vela & Jiménez Morales, 2009). No obstante, la bibliografía actual aporta escasos artículos sobre la influencia de estos eventos en la marca de la ciudad (Kowalik, 2012).
El objetivo general de esta publicación es analizar la coordinación entre los responsables municipales y los organizadores de ferias en la estrategia de city branding; comparando las ciudades de Barcelona y Milán. Los objetivos específicos son: a) conocer la estrategia de city branding de ambas ciudades; b) confirmar si los organizadores la conocen, así como sus objetivos; c) identificar si existe colaboración entre ellos para alcanzarlos y, finalmente, d) compartir recomendaciones gracias al análisis del modelo de gestión de cada ciudad.
La metodología empleada parte      desde un enfoque cualitativo      y ha consistido, en primer lugar, en entrevistas en profundidad con el ayuntamiento y los actores más relevantes de estas ciudades. En segundo término, se han articulado encuestas online para conocer la opinión de los organizadores feriales que desarrollan su actividad en estas urbes.
Evaluation of Google Play educational apps for early childhood education
Authors: Chatzopoulos Avraam , Karaflis Alexandros , Kalogiannakis Michail , Tzerachoglou Anastasios , Cheirchanteri Georgia , Sfyroera Emmanouela , Sklavounou Eleni-Orsalia
Published: July 2023

In the global retail market, there is a plethora of educational software: smartphone applications, computer programs, and websites with engaging educational activities that can be used at all levels of education: preschool, primary, secondary, tertiary, and especially in educational robotics and STEM education. However, a teacher or a parent faces a dilemma today: Which is the most educational and appropriate app for children to choose and use? This article aims to help parents, teachers, and other stakeholders in the education community. It has a double purpose: on the one hand, to present an evaluation rubric for educational apps, and on the other hand, to make use of it by offering the vital characteristics and the evaluation of well-known educational apps (n = 50) which can be downloaded from Google Play Store (https://play.google.com). Αpp selection was based on the following criteria: a) to be suitable for early childhood education (kindergarten), b) to cover a wide range of learning objectives (e.g. maths, music, visual arts, language, science, programming, history, and environment) and, c) to be free to download. The educational rubric used was a modified version adopted by literature research.
The Political-Economy of Rural Development Through Corporate Social Responsibility: An Assessment of the INs and OUTs
Authors: Mohapatra Bishnuprasad
Published: July 2023

The shift of rural development from the government’s agenda to the CSR units’ agenda is a recent political development. The Companies Act 2013 has made it mandatory for the corporate to play a significant role, sometimes as a supplement to or as a substitution for the State under the neo-liberal economy. In this context, the present study has tried to explore the role of two major industries, i.e., HAL and NALCO, in rural development in the backward district of Koraput, Odisha. The seminal contributions of these two industries in four major areas, i.e., construction of toilets, construction and repair of roads, installation of solar lights and construction and repair of water service infrastructure, have been analysed in this article. The study has relied on both quantitative and qualitative data drawing them from secondary and primary sources. The study concludes that no clear-cut financial investment on different heads is projected by the company’s CSR units, there is overlapping in the company’s inclusion of the heads of rural development, people’s felt needs are hardly reflected in the designing of rural development programmes by the CSR units, and follow-up impact assessments are rarely undertaken. So, the investments are made without a real spirit, and the dividends do not commensurate with the hefty investment. Rural development programmes floated by the CSR units are less people-centric, not sustainable and economically viable, and are more politically motivated and just done to comply with the policy mandates.
A Study on the Livelihood Assets and Income of the Plantation-Based Rehabilitated Jhumias of Tripura
Authors: Kuki Vanlalrema , Bhowmik Indraneel
Published: July 2023

The indigenous tribes of Tripura predominantly practised shifting cultivation. However, efforts at weaning them away have been done through several developmental interventions including plantation-based rehabilitation models. The present paper attempts to examine the status of income and livelihood capital endowments among four different types (rubber, tea, horticulture & multi-croppers) of plantation-based rehabilitated beneficiaries. Using primary survey data from five districts of Tripura, it is seen that multi-croppers and rubber farmers are better placed in terms of income accruals. However, horticulturists are better endowed than rubber growers in terms of livelihood assets. The tea-based rehabilitated beneficiaries are at the bottom in terms of both income as well as livelihood assets.
Fiscal Performance of Panchayati Raj Institutions (PRIs): An Empirical Analysis Of the State of Andhra Pradesh In Pre and Post-bifurcation Period
Authors: Gontupulugu Jagadeesh , Padakandla Steven Raj , Makeni Chandayya
Published: July 2023

The effectiveness of democratic decentralisation depends on the financial strength and independence of the local bodies. Financial autonomy is vital to reap the full potential benefits of decentralisation as the transfer of funds, functions, and functionaries will enable local bodies to be institutes of self -governance and not just delivery mechanisms. In the context of persistent fiscal distress across the local bodies, an attempt is made to empirically examine the fiscal performance of Panchayati Raj Institutions (PRIs) in Andhra Pradesh during 2010-11 to 2017-18, i.e. pre- and post-bifurcation periods of the State. The fiscal autonomy and the revenue dependency of PRIs across all three tiers in the State during the same period was also analysed. The study finds that the fiscal autonomy of top tiers, i.e. Mandal Praja Parishads (MPPs) and Zilla Praja Parishads (ZPPs) is negligible in both periods, while Gram Panchayats showed relatively better fiscal autonomy in both periods.
O “optativo jussivo” e outras formas de injunção no dialeto grego da Élida
Authors: Dotta Johnny , Macedo José Marcos
Published: July 2023

Este artigo tem como objeto um fenômeno sintático próprio da linguagem jurídica do dialeto grego da Élida: períodos condicionais com o uso do optativo na prótase e, na apódose, do optativo acompanhado de partícula modal, como forma de injunção. Depois de mostrar que esse emprego modal é excepcional em contraste com outros dialetos, procede-se, primeiro, à investigação das possíveis origens do uso desse modo em tais contextos, levantando hipóteses de como o uso do optativo teria ali surgido e se espalhado. Em seguida, são analisados os modos jussivos presentes nas inscrições da Élida datadas do século VI ao IV a.C. Durante esse período, o optativo com partícula modal é gradualmente substituído, primeiro pelo infinitivo e depois pelo imperativo. O exame do corpus permite sugerir que tanto critérios cronológicos quanto funcionais atuam no desenvolvimento da distribuição desses modos no grego eleio.
Assessment of community health needs in Makkah: A qualitative study
Authors: Alharbi Khulud K. , Alzahrani Ali Mohammed A. , Aldadi Majed Matir J. , Basisi Aisha Mosa M. , Alshareef Aljuhara Mushbab A. , Alghamdi Ruba Asabi M. , Aldebane Noran Talal S. , Zamzami Jumana Mohammed S.
Published: July 2023

Objectives:

Assessing population health needs have been an important factor that enables healthcare systems to attain value-based care and use resources efficiently. This study aims to assess the health needs for two communities residing in Makkah City, Saudi Arabia.

Materials and Methods:

A qualitative study design with focus groups were conducted between January 2022 and March 2022 to assess health needs among two communities residing in two different districts in Makkah City (Alzaidy and Al-hajj Street). Recruited participants were divided into five groups according to their age (0-12 (parents represented this group); 13-24; 25-45; 46-65; and over 65 years), and each group had 5 to 9 participants.

Results:

Participants have identified several needs and concerns within their communities. These needs were classified into five main themes: Access to physical activity; access to healthcare services; healthy lifestyle; environmental instability; and education/promotion programs for community. Although, identified needs varied among age groups and geographic locations of communities, the needs to access healthcare services and physical activities was frequently mentioned among participants.

Conclusion:

This is the first study to assess community health needs in Makkah. Even though the results were not generalizable, the study has laid the foundation for future projects and research assessing population health needs. A population-level data might help in determining population health needs and inform future policies and decision-making.
Musculoskeletal corticosteroid injections were used safely in patients during the COVID-19 pandemic
Authors: Raval Parag , Baguley Matthew , Singh Harvinder , Bhatt Raj , Pandey Radhakant
Published: July 2023

Objectives:

Studies have highlighted that corticosteroid use can cause immunocompromise. During the COVID-19 pandemic, caution was advised on corticosteroid injections (CSIs) use and the possibility of increasing patients’ susceptibility to COVID-19. CSI is commonly used to manage pain, which is increasingly important with prolonged waiting lists. This study aimed to assess the occurrence of COVID-19 infection following the administration of CSI for musculoskeletal pain.

Methods:

A prospective cohort study of patients receiving CSI for musculoskeletal conditions through the COVID-19 pandemic was followed. It monitored post-injection through clinical review and telephone follow-up as to whether they were diagnosed with COVID-19 or had its symptoms. Patients were administered either half or full-dose corticosteroids as per guidance at the time. Patients were followed up at 8 weeks, 3 and 6 months.

Results:

One hundred and ninety-six patients were included (100 males and 96 females). One hundred and fourteen patients received 40 mg of Depo-Medrone, and 90 received 20 mg of Depo-Medrone. No patients suffered COVID-19 symptoms or had positive viral polymerase chain reaction (PCR) tests by 3-month follow-up. By the 6-month follow-up, four of the cohort had mild symptoms and a positive PCR test for COVID-19. None required hospitalization.

Conclusion:

Our study demonstrated only a 2% incidence of COVID-19 infection following the administration of CSI for musculoskeletal pain within the 6-month follow-up, despite a high local prevalence for infection. We observed no correlation between CSI and COVID-19 acquisition and noted no clear increase in risk. We would therefore endorse CSI use if required for patients after careful patient selection and shared decision-making.
Opportunities of digital teaching in process control: flip the classroom, provide a level playing field, and integrate external experts
Authors: Mädler Jonathan , Viedt Isabell , Khaydarov Valentin , Lorenz Julius , Urbas Leon
Published: July 2023

After serval periods of remote teaching in the COVID-19 pandemic, many academic institutions are working on concepts to transfer the lessons learned about digital teaching into their didactic concepts. In this paper, we present a didactic concept for courses with student groups of heterogenous educational background. It is based on a self-paced learning phase with self-study materials, a flipped classroom session for interactive problem solving in interdisciplinary student groups, an exercise session for more complex problems, and a student project. An important key feature is that (1) the students can learn according to their educational background in the self-paced learning stage and teach each other in the other parts of the course. Additional features are (2) the maximized share of the student-staff contact time spent on cooperative problem solving and (3) the collaborative development of teaching materials with external experts. The concept was implemented within our course on process control. The results are illustrated via the example of a digital teaching module for hybrid semi-parametric modeling.
Textilveredlung als inverted classroom mit OPALWiki
Authors: Kruppke Iris
Published: July 2023

Im Rahmen zweiter Lehrveranstaltungen im Bereich Textilveredlung wurde eine inverted classroom-Methode (ICM) in Kombination mit einem Wikipedia (Wikis) umgesetzt. Das Wikipedia ist Teil der Lernplattform OPAL. Das vorgestellte Lehr-Lern-Konzept beinhaltet die Erstellung des Wikis auf Basis von Selbstlernaufträgen als asynchrone Lerneinheiten, die in einer Synchronphase in der Lehrveranstaltung mittels einer durch die Studierenden selbst gewählten Umsetzungsmethode vorgestellt werden. Dieser Teil entspricht dem ICM. Des Weiteren wurden die Lehrinhalte wiederum asynchron als Wiki ins OPAL eingepflegt. Als Qualitätssicherungsmethoden wurden sowohl ein peer review-Prozess für die Einträge als auch eine Zwischenevaluation durchgeführt.
Dynamic partitioning of surfactants into non-equilibrium emulsion droplets
Authors: Balaj Rebecca , Xue Wangyang , Bayati Parvin , Mallory Stewart , Zarzar Lauren
Published: July 2023

Emulsion droplets, such as oil-in-water droplets stabilized by surfactant, are ubiquitous in products ranging from food to pharmaceuticals to paints. However, emulsion droplets are often thermodynamically unstable and thus persist under non-equilibrium conditions for extended times. As such, equilibrium properties like partition coefficients or interfacial tensions may be inadequate to describe the properties of an out-of-equilibrium droplet that can potentially experience conditions not accessible at equilibrium. Here, the partitioning of nonionic surfactants between microscale oil droplets and water is investigated under non-equilibrium conditions wherein the droplets are shrinking in volume over time via solubilization. Quantitative mass spectrometry is used to analyze the composition of individual micro-droplets as a function of time under conditions of varying droplet diameter, surfactant molecular structure and concentration, and oil molecular structure. We find that common nonionic surfactants partition into the oil droplets over a timescale of minutes and reach a non-equilibrium steady state; this steady state concentration can be orders of magnitude higher than the aqueous phase surfactant concentration and higher than what is accessible under equilibrium partitioning conditions. Using kinetic data and steady state apparent partition coefficients, we describe the surfactant distribution between the water and droplet using a mass transfer model. Over longer timescales of hours, the droplet sheds accumulated surfactant back into the water, creating transiently high concentrations of oil and surfactant near the droplet interface which leads to the evolution of ultralow interfacial tension. Introduction of an ionic surfactant that forms mixed micelles with the nonionic surfactant reduces the nonionic surfactant transfer into oil; based on this observation, we use stimuli-responsive ionic surfactants to trigger phase separation and mixing inside droplets via modulation of the nonionic surfactant partitioning. This study thus reveals generalizable non-equilibrium states and conditions experienced by solubilizing droplets which govern emulsion properties.
Melt electrowriting of nylon-12 microfibers with an open-source 3D printer
Authors: Reizabal Ander , Devlin Brenna , Paxton Naomi , Saiz Paula , Liashenko Ievgenii , Luposchainsky Simon , Woodruff Maria , Lanceros-Mendez Senentxu , Dalton Paul
Published: July 2023

This study demonstrates how either a heated flat or cylindrical collector enables defect-free melt electrowriting (MEW) of complex geometries from high melting temperature polymers. The open-source "MEWron" printer uses nylon-12 filament and combined with a heated flat or cylindrical collector, produces well-defined fibers with diameters ranging from 33±4 µm to 95±3 µm. We optimize processing parameters for stable jet formation and minimal defects based on thermal modeling for hardware design. We achieve the balance of processing temperature and collector temperature to achieve auxetic patterns, while showing that annealing nylon-12 tubes significantly alters their mechanical properties. The samples exhibit varied pore sizes and wall thicknesses influenced by jet dynamics and fiber bridging. Tensile testing shows nylon-12 tubes are notably stronger than PCL ones and while annealing has limited impact on tensile strength, yield, and elastic modulus, it dramatically reduces elongation. The equipment described and material used broadens MEW applications for high melting point polymers and highlights the importance of cooling dynamics for reproducible samples.
Taylor-dispersion induced phase separation for the efficient characterisation of protein condensate formation
Authors: Norrild Rasmus , Mason Thomas , Boyens-Thiele Lars , Ray Soumik , Mortensen Joachim , Fritsch Anatol , Iglesias-Artola Juan , Klausen Louise , Stender Emil , Jensen Henrik , Buell Alexander
Published: July 2023

Biomolecular condensates have emerged as important structures in cellular function and disease, and are thought to form through liquid-liquid phase separation (LLPS). Thorough and efficient in vitro experiments are therefore needed to elucidate the driving forces of protein LLPS and the possibility to modulate it with drugs. Here we present Taylor dispersion induced phase separation (TDIPS), a method to robustly measure condensation phenomena in a commercially available microfluidic platform. It uses only nano-liters of sample, does not require extrinsic fluorescent labels, and is straightforward to implement. We demonstrate TDIPS by screening the phase behaviour of two proteins that form biomolecular condensates \textit{in vivo}, PGL-3 and Ddx4N1. Uniquely accessible to this method, we find an unexpected re-entrant behaviour at very low ionic strength, where LLPS is inhibited for both proteins. TDIPS can also probe the reversibility of assemblies, which was shown for both alpha-synuclein and for Lysozyme, relevant for health and biotechnology, respectively. Finally, we highlight how effective inhibition concentrations and partitioning of LLPS-modifying compounds can be screened efficiently at high throughput.
AutoParams: An Automated Web-Based Tool To Generate Force Field Parameters for Molecular Dynamics Simulations
Authors: Hix Mark A. , Walker Alice R.
Published: July 2023

The growth of machine learning as a predictive tool in biochemical research has led to an increased need for large-scale datasets. Certain research questions benefit from molecular dynamics simulations to observe the motions and conformations of molecules over time, however contemporary methods rely on forcefields which describe sets of common biomolecules. Unusual molecules, such as nucleotide analogues, functionalized carbohydrates, and modified amino acids are often ill-described in standard forcefields, requiring the development of custom parameters for each unique molecule. While these parameters may be created by individual users, the process is time-consuming and can introduce errors that may not be immediately apparent. We present an open-source automated parameter generation service, AutoParams, which requires minimal input from the user and creates useful forcefield parameter sets for most molecules, particularly those that combine molecular types (ex: a carbohydrate functionalized with a benzene). It can be straightforwardly linked to any charge generation program, and currently has interfaces to PsiRESP and TeraChem, and is available via GitHub and as a Docker container. It includes error checking and testing protocols to ensure the parameters will be sufficient for subsequent molecular dynamics simulations, and streamlines the creation of force field databases.
Accelerated recovery program for patients after laparoscopic correction of pelvic organ prolapse: A prospective study
Authors: Dobrokhotova Yulia E. , Lapina Irina A. , Tyan Anatoly G. , Taranov Vladislav V. , Chirvon Tatiana G. , Glebov Nikita V. , Kaykova Olesya V. , Malakhova Anastasiya A. , Gomzikova Valeriia M. , Klaushuk Vladislava I.
Published: July 2023

Pelvic organ prolapse belongs to the group of multidisciplinary pathological processes, in the pathogenesis of which various etiological components are involved, leading to destabilization of ligaments and muscular-fascial system. In most cases, pelvic floor dysfunction requires surgical treatment, which allows eliminating defects and reducing clinical symptoms, also improving quality of life of patients. Performing surgeries for genital prolapse using laparoscopic approach is associated with high efficiency and low risk of unfavorable clinical outcomes. However, despite significant progress and improvement of surgical treatment options, the choice of the rational treatment in terms of a personalized approach remains relevant. This literature review analyzes classical and alternative modes of laparoscopic correction of pelvic organ prolapse.
Clinical and anamnestic risk factors for the development of uterine leiomyoma in women of reproductive age: A case control study
Authors: Malyshkina Darya A. , Sotnikova Nataliya Yu. , Voronin Dmitriy N. , Kalinina Arina E. , Godunova Elizaveta M. , Golubeva Maria V. , Rumyanceva Elizaveta V.
Published: July 2023

Aim. To identify risk factors for uterine leiomyoma (ULM) in women of reproductive age based on the study of clinical and medical history features in various tumor types.
Materials and methods. The study included 82 women of reproductive age with symptomatic ULM (the main group) and 47 somatically healthy women of reproductive age without proliferative gynecological diseases who underwent elective treatment at the Gorodkov Ivanovo Research Institute of Motherhood and Childhood (Director is professor AI Malyshkina, MD, Ph.D.). The study patients underwent general clinical examinations, ultrasound examination of the pelvic organs, histological examination of endometrial biopsy specimens, and myomatous nodes in women of the main group.
Results. The following risk factors and clinical and history features were identified in women with uterine fibroids: late reproductive age (p=0.000), unregistered marriage (p=0.026), employment (p=0.006), history of profuse and painful menstruation (p=0.000 and p=0.000, respectively), inflammatory diseases of the respiratory system (p=0.003), pain syndrome and profuse menstruation (p=0.000 and p=0.000, respectively), endometrial hyperplasia without atypia, and chronic endometritis according to histological examination (p=0.000 and p=0.000, respectively). When comparing the subgroups "Ki67+" and "Ki67-", we obtained the following clinical and history features in women with proliferating uterine fibroids: varicose disease of the lower extremities (p=0.035); and when comparing the subgroups "with secondary changes" and "without secondary changes", we found a higher rate of pain (p=0.038) in women with secondary changes in the myomatous node, as well as a tendency to a higher rate of painful menstruation (p=0.093) and endometrial hyperplasia (p=0.093).
Conclusion. Risk factors for ULM in women of reproductive age can be divided into modifiable ones, which include social disadvantage (unregistered marriage, hard physical work), inflammatory factor (inflammatory diseases of the respiratory system) and unmodifiable (late reproductive age). Clinical and history features of women with Ki67+ ULM compared to women with Ki67- ULM include more frequent use of barrier contraception, high prevalence of varicose vein disease of the lower extremities, and surgical interventions on the pelvic organs. Also, according to histological examination, women with ULM with secondary changes in the myomatous node, compared to women with ULM without secondary changes in the myomatous node, have a higher prevalence of painful menstruation, pain syndrome, and concomitant endometrial hyperplasia.
Outcomes of organ-preserving treatment of atypical hyperplasia and early stage endometrial cancer in reproductive age: A prospective and retrospective study
Authors: Gadzhieva Lyubov T. , Pronin Stanislav M. , Pavlovich Stanislav V. , Kometova Vlada V. , Ashrafyan Levon A.
Published: July 2023

Aim. To evaluate the effectiveness of the intrauterine levonorgestrel-releasing device (LNG-IUD) in the treatment of atypical hyperplasia and the use of LNG-IUD in combination with a gonadotropin-releasing hormone analog (3.6 mg goserelin depot) in the treatment of stage Ia highly differentiated endometrial adenocarcinoma in women wishing to preserve childbearing function, and to assess reproductive outcomes after treatment in these women.
Materials and methods. A prospective and retrospective series of cases included all patients treated with LNG-IUD or LNG-IUD combined with goserelin 3.2 for atypical hyperplasia or early endometrial cancer (EC) treated in the Department of Innovative Oncology and Gynecology of the Institute of Oncogynecology and Mammology of the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology from January 2018 to March 2022. Response rates and the relationship of the response with clinical and pathological factors were calculated.
Results. Fifty-six patients diagnosed with atypical hyperplasia or stage Ia highly differentiated endometrial adenocarcinoma were treated with LNG-IUD and LNG-IUD combined with 3.2 mg of goserelin. Of the 56 patients who completed a 6-month course of hormonal treatment, 42 (82%) showed a complete response: 22 (91.7%) with atypical endometrial hyperplasia (AEH) and 20 (74.1%) with EC. In 4 (7.8%) patients, a partial response was reported: 2 (8.3%) with AEH and 2 (7.4%) with EC. No response was noted in 5 (9.8%) patients in the EC group only. Childbirth was reported in 13 (23.2%) women: 8 (29.6%) with AEH and 5 (17.2%) with EC. Two (3.6%) women were in the second trimester of pregnancy, and 17 (30.4%) women had an early pregnancy loss; 7 (25.9%) of them had AEH, and 10 (34.5%) had EC. The positive response rate was 90.2% at 6 months: 24 (100%) patients with atypical hyperplasia and 22 (81.5%) with EC. Patients with EC in combination with polycystic ovary syndrome and obesity and patients with the non-obese EC phenotype had a lower therapy efficacy.
Conclusion. LNG-IUD therapy for the conservative treatment of atypical hyperplasia and LNG-IUD therapy combined with goserelin 3.2 for early EC led to a morphological cure in most patients and can be considered for women planning pregnancy.
National medical eligibility criteria for contraceptive use 2023: focus on women's reproductive health: A review
Authors: Andreeva Elena N. , Sheremetyeva Ekaterina V. , Prilepskaya Vera N.
Published: July 2023

Reproductive health care involves helping families in this area with the provision of the necessary information. This is recognized as a key step in improving the health of men, women and children and is a fundamental human right. Everyone has the right to have access to a correct understanding of reproductive health care, choice of contraceptive method and the opportunity to benefit from scientific progress in this area. Over the past 35 years, significant progress has been made in the development of new contraceptives: the content of hormones in combined oral contraceptives has significantly decreased, inert intrauterine contraceptives have been replaced by more progressive, levonorgestrel-containing ones including low-dose generation. Combined hormonal compounds were synthesized in the form of injections, patches and vaginal rings, progestogen implantable and injectable contraceptives. Women who use contraceptives must take into account the state of health (including the presence of endocrine pathology) in order to use them without harm to their health. Based on the World Health Organization Medical Eligibility Criteria for Contraceptive Methods 2015, the Russian Medical Eligibility Criteria for Contraceptive Methods 2023 is designed to become an important tool in daily practice of doctors.
Clinical characteristics and confounders of the new coronavirus infection in low-risk pregnant women: an analysis of three years of the pandemic: A cross sectional study
Authors: Belokrinitskaya Tatiana E. , Frolova Nataly I. , Kargina Kristina A. , Shametova Evgeniya A. , Chuprova Mariya I. , Rodionova Kristina A.
Published: July 2023

Background. During the three years of the new coronavirus infection (NCI) pandemic, young women of low infectious risk made a certain contribution to the severe maternal morbidity and mortality from COVID-19.
Aim. To establish risk factors for morbidity and give a clinical assessment of COVID-19 during epidemic outbreaks in 2020, 2021, and 2022 in low-risk pregnant women.
Materials and methods. The study included three groups of pregnant women with clinically manifested and laboratory-confirmed SARS-CoV-2 infection: 163 pregnant women who became ill in the first wave of the epidemic in October-December 2020, 158 in the second and third epidemic wave in July and October 2021, and 160 in the fourth epidemic wave in JanuaryFebruary 2022. Each comparison group included 100 pregnant women who did not become ill during the same periods of the pandemic. Patients of all groups were in the III trimester of gestation, comparable in age (1835 years), social status, parity, and body mass index, and had no known risk factors for COVID-19.
Results. Iron-deficiency anemia, tobacco smoking, and belonging to the East Asian ethnic group showed a stable association with the incidence of COVID-19 in low-risk pregnant women. In the first year of the pandemic (strains zero and Alpha), the clinical presentation of NCI was dominated by a loss of smell and/or taste (87.7%), drowsiness (68.7%), and dyspnea even with a mild degree of lung damage (68.1%). The epidemics of the second year of the COVID-19 pandemic (Delta strain) were characterized by a more severe course of the disease than in the first year: fever was more often reported above 38C (19.6% vs 7.4%; p2=0.006), pneumonia confirmed by computed tomography (61.4% vs 21.4%; p20.001), severe lung damage (CT-3: 11.4% vs 4.9%; p2=0.040; CT-4: 0 vs 6.3%; p20.05), intensive care unit admission (11.4% vs 6.4%; p2=0.041); there were cases of invasive mechanical ventilation (1.89% vs 0; p2=0.118) and deaths (0.63% vs 0; p2=0.492). In the epidemic of the third year of the pandemic (Omicron strain), the COVID-19 clinical presentation was similar to seasonal acute respiratory viral infection: the predominant symptoms included runny nose (66.7%) and cough (54.4%); pneumonia was rare (3.8%).
Conclusion. Iron deficiency anemia, tobacco smoking, and belonging to the East Asian ethnic group are confounders of COVID-19 disease in pregnant women without known infectious risk factors. Unlike the epidemics of the first and third year of the pandemic with dominant zero, Alpha, and Omicron strains, epidemic outbreaks of the second year of COVID-19 caused by the Delta strain were characterized by the most severe disease course, a high rate of pneumonia and deaths even in low-risk patients.
Complex questions about combined hormonal contraception: A review
Authors: Prilepskaya Vera N. , Bostandzhian Lana L.
Published: July 2023

Combined oral contraceptives (COCs) containing synthetic analogs of sex steroids are considered the most effective and popular method of contraception worldwide. The low rate of hormonal contraceptive use is often because of the fear of side effects due to existing myths. Complex questions that most often arise among doctors and patients when choosing COCs include the risk of thrombosis and cancer, the effect on fertility after the use of COCs, the use of COCs in patients with COVID-19, etc. COCs are highly effective, well-studied, and pose minimal risks that are well understood, described in the labels, and can be avoided with proper use.
Effect of activated glycyrrhizic acid on epithelial cell lipidome in HPV-associated cervical lesions: A prospective cohort study
Authors: Tokareva Alisa O. , Ramazanova Leyla K. , Dovletkhanova Elmira R. , Alieva Leyla E. , Sheshko Polina L. , Kukaev Evgenii N. , Nazarova Niso M. , Starodubtseva Natalia L. , Chagovets Vitaly V. , Frankevich Vladimir E. , Prilepskaya Vera N.
Published: July 2023

Aim. To determine the change of lipid levels in the cervical epithelial cells during the treatment of chronic cervicitis and low-grade squamous intraepithelial lesions (LSIL) with 0.1% activated glycyrrhizic acid.
Materials and methods. The prospective cohort study included 40 patients with chronic cervicitis and 40 patients with LSIL. Cytological evaluation of cervical smears was performed according to the Bethesda system (2014). All patients received Epigen Intim Spray for 18 months. Amplification of type-specific DNA fragments of human papillomavirus (HPV) and human DNA (sampling control SC) was done using a kit of reagents to detect, type, and quantitatively determine 21 HPV types by Quantum-21 HPV PCR. Lipid extract of a cervical epithelial scraping taken before and after therapy was analyzed by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). Lipids were identified using the Lipid Match R-script and by characteristic MS/MS. Correlation analysis of the lipidome of cervicovaginal fluid and SC was performed using the Spearman test, and the Mann-Whitney test was used to compare lipid levels at the two time points.
Results. During the treatment of chronic cervicitis, the levels of CL lipids 16:0_16:1_18:1_18:1, HexCer-NDS d20:0/26:0, PC 16: 0_18: 1 and 16: 0_20:4 were decreasing; during the treatment of LSIL, the levels of ceramides and glucosylceramides were decreasing. Chronic cervicitis is characterized by a positive correlation of SC smear with cardiolipins, glucosylceramides, and epithelial lipids with an ether bond; LSIL showed a negative correlation with phosphatidylcholines and phosphatidylethanolamines with an ether bond.
Conclusion. As a result of treatment with activated glycyrrhizic acid, the lipid spectrum of epithelial cells significantly changed, depending on the type of lesion. It is also necessary to consider SC scrapings in further studies of epithelial cell lipidome and the type of HPV-associated lesions that affects the adjustments.
COGNITIVE SKILLS IN THE DEVELOPMENT OF CRITICAL THINKING: MECHANISMS OF THESIS ARTICULATION
Authors: Суханова Н.П.
Published: July 2023

Практика развития критического мышления рассматривается в отношении значимости артикуляции тезиса в процессе аргументации как неотъемлемый когнитивный навык учащихся. Целью статьи является изучение механизмов артикуляции тезиса в рамках образовательного проекта «Логика и критическое мышление». Показана необходимость тщательного подбора понятий и суждений в целях избегания ошибок при формулировании тезиса в контексте несовершенства языковых средств. Анализ влияния артикуляции тезиса на успех аргументации осуществляется с учетом особенностей когнитивного поведения участников проекта. Исследуются инструменты артикуляции тезиса, которыми овладевают учащиеся, выстраивая собственную аргументацию. Полученные результаты демонстрируют успешное закрепление критических навыков участников проекта посредством создания информационной среды, содержащей примеры логически корректных аргументативных структур. Делается вывод о ценности детального овладения вопросом артикуляции тезиса для аргументации в обучении критическому мышлению.

The practice of developing critical thinking is considered in relation to the importance of articulating a thesis in the process of argumentation as an integral cognitive skill developed by students. The purpose of the article is to study the mechanisms of articulation of the thesis in the framework of the educational project «Logic and critical thinking». The necessity of careful selection of concepts and judgments in order to avoid mistakes when formulating a thesis in the context of imperfection of linguistic means is shown. The analysis of the impact of the articulation of the thesis on the success of argumentation is carried out taking into account the peculiarities of the cognitive behavior of the project participants. The article explores the tools of articulation of the thesis, which are mastered by students, building their own argumentation. The results obtained demonstrate the successful consolidation of critical skills of project participants by creating an information environment containing examples of logically correct argumentative structures. The conclusion is made about the value of detailed mastery of the issue of articulation of the thesis for argumentation in teaching critical thinking.
Antecipação da transferência de embriões em éguas receptoras em anestro estacional
Authors: Neves Marcos Daniel , Laquiz Nayara Christina Silva , Testa Alessandra Crossara , Quintal Amanda Pifano Neto , Vasconcelos André Belico de
Published: July 2023

O objetivo do trabalho foi avaliar a taxa de prenhez de éguas receptoras acíclicas preparadas com protocolo de estrógeno e progesterona (P4), em período alternativo da janela de sincronização. O estudo foi realizado em Acreúna (GO), em arrendamento comercial. Para tal, foram utilizadas éguas receptoras (n=15) divididas em três grupos: G1 (n=5) - anestro estacional natural; G2 (n=5) - éguas em anestro estacional utilizadas no terceiro dia (D3) após aplicação de P4; e G3 (n=5) - éguas em anestro estacional utilizadas no quinto dia (D5) após aplicação de P4. As éguas foram acompanhadas via palpação transretal e ultrassonografia, quanto às condições uterinas e foliculares. Foi aplicada análise descritiva em percentual, seguida do teste de contingência Qui-quadrado, avaliando as taxas de prenhez ao nível de significância de 95%. Dos resultados, observamos que éguas acíclicas usando progesterona de longa ação tiveram taxas de prenhez igual ou maior que éguas cíclicas. Conforme os dados na análise da janela de sincronização adotada neste estudo, não houve diferença entre os momentos de inovulação, uma vez que as receptoras acíclicas submetidas ao protocolo de estrógeno e progesterona e inovuladas no D3 (G2) mostraram 80% de taxa de prenhez, enquanto animais do G1 e G3 apresentaram taxa de prenhez em 60%. Assim, a antecipação da janela de sincronização convencional do quarto (D4) ao oitavo dia (D8) para D3 a D8 propicia índices gestacionais satisfatórios, otimizando o uso de receptoras acíclicas.
UVODNIK
Authors: Prislan Peter
Published: July 2023

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Makroekonomski učinki proizvodnje in predelave lesa listavcev
Authors: Arnič Domen , Prislan Peter , Juvančič Luka
Published: July 2023

As far as the utilization of the value-added potential of hardwood assortments is concerned, we have considerable reserves in Slovenia. These could be exploited mainly by increasing the economic use of roundwood in Slovenia and by developing more technologically advanced processing methods for roundwood. The aim of this paper is to assess the untapped potential of the forest-wood chain in Slovenia using input-output models, focusing on the use of hardwood. For the whole forest-wood chain, we assessed the existing situation and tested five scenarios for the improvement of the forest-wood chain in Slovenia. We developed a national input-output model to evaluate possible scenarios for the future development of the wood-based bioeconomy. The results of scenario analysis of the input-output model show that the Slovenian wood-based bioeconomy can achieve up to 20% higher production value, a 24% increase in employment and 19% increase in household income in the future through restructuring of economic activities. In the paper, we discuss how upgrading the forestry and wood-processing industry (according to the defined scenarios) could be achieved by increasing the processing capacity of hardwoods and provide recommendations for decision makers.
Дослідження процесу пакетування металевої стружки
Authors: Чернишов Олександр Олександрович , Чернишов Олександр Васильович , Чухно Сергій Іванович , Яновський Валерій Анатолійович
Published: July 2023

Вимиту та висушену металеву стружку найбільш доцільно використовувати у сталеплавильному виробництві у вигляді пакетів або брикетів. Це дозволяє перетворити стружку на якісний шихтовий матеріал, який при переплавленні замінює металевий шматковий брухт. Варто зауважити, що одержати якісні пакети з металевої стружки практично неможливо, а тому дослідження процесів окусковування стружки є актуальними та важливими. В Україні значний внесок у розвиток процесів окусковування металевого лому і стружки зробили вітчизняні учені Інституту чорної металургії, Національної металургійної академії України та Дніпровського державного технічного університету.
У промисловості отримали поширення два методи окусковування стружки: брикетування і пакетування. Для брикетування рекомендується використовувати тільки подрібнену стружку. Другим методом окусковування металевої стружки є її пакетування. Але пакетувати спіралеподібну сталеву стружку не вдається, оскільки при великих зусиллях пресування вона руйнується, а при малих зусиллях пакети розсипаються. Тому пакетування сталевої стружки необхідно проводити у відпаленому стані. Така технологія пакетування стружки була запропонована та досліджувалася в лабораторіях кафедри технології машинобудування Дніпровського державного технічного університету. Експериментальні дослідження процесу пакетування сталевої стружки проводилися з метою визначення оптимальних режимів пакетування за запропонованою технологією. Дослідження проводилися на лабораторному пресі пакетування, а також на промисловому пресі БА–1330.
У статті розглянуто та описано існуючі в промисловості способи пакетування та брикетування металевої стружки, запропоновано технологію пакетування стружки у відпаленому стані. На підставі отриманих результатів зроблено рекомендації з удосконалення обладнання та розглянуто технологію пакетування стружки.
Аналіз кореляцій між фрактальною розмірністю та параметрами шорсткості фрезерованої поверхні
Authors: Балицька Наталія Олександрівна , Прилипко Олександр Іванович , Шостачук Андрій Миколайович , Глембоцька Лариса Євгеніївна , Мельник Олександр Леонідович
Published: July 2023

Функціональні властивості виробів залежать від комплексу факторів, при цьому одним із основних факторів є текстура їх поверхонь. Це пояснює значну увагу до визначення та формування таких параметрів текстури механічно обробленої поверхні, які б забезпечували необхідний рівень коефіцієнтів тертя під час ковзання та кочення, змочуваності, контактної жорсткості, зносостійкості за змінних навантажень, корозійної стійкості, маслоємності тощо. У роботі представлено результати дослідження кореляційного зв’язку між параметрами шорсткості і фрактальною розмірністю розподілу елементів площі поверхонь зразків з алюмінієвого сплаву Д16Т після торцевого фрезерування при змінних режимах різання. Було проведено два однофакторні експерименти, в першому змінним фактором була глибина різання, в другому – величина подачі, при цьому швидкість різання залишалася постійною. За допомогою щупового профілографа вимірювалися параметри шорсткості оброблених поверхонь. Визначення фрактальної розмірності Гаусдорфа виконувалося в програмі Gwyddion. Математична обробка результатів експериментального дослідження здійснювалася із застосуванням вибіркового коефіцієнта кореляції Пірсона. Це дозволило встановити наявність кореляційного зв’язку між параметрами шорсткості і фрактальною розмірністю поверхонь зразків зі сплаву Д16Т після торцевого фрезерування при змінних режимах різання. Обговорюються результати проведеного аналізу кореляційного зв’язку між параметрами шорсткості і фрактальною розмірністю поверхонь зразків. Обґрунтована необхідність подальших наукових пошуків для більш глибокого розуміння фізичних явищ, які відповідальні за весь комплекс параметрів текстури фрезерованої поверхні та їх вплив на функціональні властивості поверхонь виробів.
Комплексна оцінка тріщинуватості та блочності габро Пшеничного родовища
Authors: Іськов Сергій Станіславович , Левицький Володимир Григорович , Криворучко Андрій Олексійович , Кірейцева Ганна Вікторівна , Темченко Анатолій Георгійович
Published: July 2023

Для забезпечення правильної розробки родовища й використання ефективних технологій з видобування каменю потрібно робити комплексну оцінку структурних показників масиву, зокрема, виконувати дослідження поширення тріщин у масиві, орієнтації головних систем тріщин, анізотропних властивостей каменю та надавати прогноз по виходу товарних блоків каменю. За рахунок цього можуть бути досягнуті підвищення ефективності видобування блоків, мінімізація втрат сировини декоративного каменю під час його видобування та підвищення економічності розробки родовища.
Для комплексної оцінки тріщинуватості та блочності габро Пшеничного родовища було вивчено документацію по керну 11 розвідувальних свердловин, проведених при розвідці родовища, опрацьовано документацію по кар’єру дослідно-промислового видобування. За результатами обробки початкових даних виконано оцінку тріщинуватості та блочності, побудовано рози-діаграми, кругові діаграми та плани тріщинуватості в ізолініях. Виокремлено поширені на родовищі системи тріщин. Оцінка блочності виконувалася за керном розвідувальних свердловин та результатами дослідного видобування блоків.
Обґрунтування доцільності застосування алюмінієвого профілю для армування виробів з природного каменю
Authors: Котенко Володимир Володимирович , Піскун Ігор Анатолійович
Published: July 2023

Стаття присвячена дослідженню доцільності застосування алюмінієвого профілю для армування виробів з природного каменю. Головною метою цієї роботи є виконання оцінки можливості використання алюмінієвого профілю як матеріалу для армування природного каменю. У статті розглянуто основні переваги алюмінієвого профілю, такі як його легкість, міцність, корозійна стійкість і довговічність. Проаналізовано процес виготовлення та властивості алюмінієвого профілю, а також розглянуто питання доцільності його використання для армування виробів з природного каменю. На основі експериментальних досліджень і порівняльного аналізу було встановлено, що алюмінієвий профіль може ефективно використовуватися для армування виробів з природного каменю. Він забезпечує достатню міцність і стійкість виробів, дозволяючи знизити їх вагу і полегшити процес монтажу. Отримані результати дослідження вказують на потенційну перспективність використання алюмінієвого профілю для армування виробів з природного каменю, проте лише за певних умов, які будуть зумовлені типорозміром виробу та способом його застосування.