bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of Targeted Therapy in Patients with Metastatic Renal Cell Carcinoma: Clinical and Economic Impact in a Canadian Real-Life Setting
Authors: Nazha S. , Tanguay S. , Kapoor A. , Jewett M. , Kollmannsberger C. , Wood L. , Bjarnason G. , Heng D. , Soulières D. , Reaume N. , Basappa N. , Lévesque E. , Dragomir A.
Published: February 2019

Introduction Outside of randomized controlled clinical trials, the understanding of the effectiveness and costs associated with targeted therapies for metastatic renal cell carcinoma (mrcc) is limited in Canada. The purpose of the present study was to use real-world prospective data to assess the effectiveness and cost of targeted therapies for patients with mrcc. Methods The Canadian Kidney Cancer Information System, a pan-Canadian database, was used to identify prospectively collected data relating to patients with mrcc. First- and subsequent-line time to treatment termination (ttt) was determined from therapy initiation time (sunitinib or pazopanib) to discontinuation of therapy. Kaplan– Meier survival curves were used to estimate the unadjusted and adjusted overall survival (os) by treatment. Unit treatment cost was used to estimate the cost by line of treatment and the total cost of therapy for the management of patients with mrcc. Results The study included 475 patients receiving sunitinib or pazopanib in the first-line setting. Patients were treated mostly with sunitinib (81%); 19% of patients were treated with pazopanib. The median ttt in the first line was 7.7 months for patients receiving sunitinib and 4.6 months for those receiving pazopanib (p < 0.001). The adjusted os was 32 months with sunitinib and 21 months with pazopanib (hazard ratio: 1.61; p < 0.01). The total median cost of first- and second-line treatments was $56,476 (interquartile range: $23,738–$130,447) for patients in the sunitinib group and $46,251 (interquartile range: $28,167–$91,394) for those in the pazopanib group. Conclusions For the two therapies, os differed significantly, with a higher median os being observed in the sunitinib group. The cost of treatment was higher in the sunitinib group, which is to be expected with longer survival.
Appropriate Treatment Receipt after Breast-Conserving Surgery
Authors: Guidolin K. , Lock M. , Vogt K. , McClure J. A. , Winick-Ng J. , Vinden C. , Brackstone M.
Published: February 2019

Background Breast-conserving surgery (bcs) and radiation therapy (rt) are the standard of care for early breast cancer, although some women receive ipsilateral mastectomy or adjuvant tamoxifen, both of which can be appropriate alternatives to rt. Objectives of the present study were to determine the proportion of women who are treated appropriately after bcs and to identify factors associated with non-receipt of rt. Methods This retrospective cohort study used Ontario data linked at the Institute for Clinical and Evaluative Sciences to examine 33,718 patients who received bcs during 2004–2010. Primary outcome was rt receipt. The ipsilateral mastectomy rate and patient, surgeon, and setting variables were measured. Results Of the study patients, 86.1% received either rt or completion mastectomy; in the cohort less than 70 years of age, 90.8% received rt or completion mastectomy. Among patients less than 70 years of age, 3 risk factors for nonreceipt of rt were identified: age less than 46 years, treatment in a non-academic institution, and earlier year of initial bcs. Additionally, in the overall cohort, rt non-receipt was associated with high comorbidity, more than 40 km to the cancer centre, income quintile, and breast care specialization. Conclusions In Ontario, 90.8% of patients less than 70 years of age are appropriately treated for early breast cancer; approximately 1 in 10 do not receive rt or completion mastectomy. Based on those findings, women less than 46 years of age might be at increased risk of recurrence and death because of incomplete treatment. It also appears that academic centres more effectively treat breast cancer; however, breast cancer care appears to be improving over time in Ontario.
Multiple Remissions of Extracavitary Primary Effusion Lymphoma Treated With a Single Cycle of Liposomal Doxorubicin in a Patient Infected With HIV
Authors: Chen J. , Mehraj V. , Szabo J. , Routy B. , Michel R.P. , Routy J.P.
Published: February 2019

Primary effusion lymphoma (PEL) is a rare human herpesvirus 8 (HHV8)–related large B cell lymphoma with plasmablastic, immunoblastic, or anaplastic features that often carries a poor prognosis. This lymphoma occurs mainly in patients with hiv infection, most often with Epstein–Barr virus (EBV) co-infection, and usually presents as body cavity effusions or, less commonly, as extracavitary lesions without effusion (EC-PEL). Chemotherapeutic treatment options are limited and require concurrent antiretroviral therapy (ART). Here, we report the case of an adult patient with HIV infection and chronic hepatitis E virus (HEV) co-infection who had low CD4 T cell recovery after years of ART. The patient then developed a cutaneous EC-PEL which rapidly regressed after 1 cycle of liposomal doxorubicin (LD) for his Kaposi sarcoma (KS) before treatment with chop chemotherapy. He had previously received numerous cycles of LD for cutaneous ks over 2 years. Because of the patient’s low CD4 T cell count, HEV co-infection, and earlier unexpected remission of EC-PEL before CHOP, the patient opted for a single trial of LD before other options. Surprisingly, he experienced a complete remission lasting 18 months. Subsequently, his EC-PEL relapsed twice at 31 and at 41 months after the initial diagnosis. Upon recurrence, a similar single cycle of LD was given, which again induced remission. The patient today is in complete remission after a total of 4 LD infusions over 54 months. This patient represents a unique case of HIV-with-HHV8–related, EBV-negative EC-PEL with chronic HEV coinfection, in which rapid remission was achieved after a single cycle of LD, suggesting an antiviral response in addition to the chemotherapeutic effect.
Real-World Benefit of Nivolumab in A Canadian Non-Small-Cell Lung Cancer Cohort
Authors: Juergens R.A. , Mariano C. , Jolivet J. , Finn N. , Rothenstein J. , Reaume M.N. , Faghih A. , Labbé C. , Owen S. , Shepherd F.A. , Villeneuve J. , Romeyer F. , Pettersson F. , Butts C.
Published: February 2019

Background: Nivolumab was the first immuno-oncology agent available for the treatment of lung cancer in Canada. In the present study, we evaluated the real-world benefit of nivolumab in Canadian patients with lung cancer. Methods: Patients included in the cohort were identified from a registry of patients treated through expanded access to nivolumab before and after Health Canada approval. Demographics were collected from the application forms. Outcome data for the duration of treatment and survival were collected retrospectively. Results: In contrast to the randomized clinical trial populations, our study cohort included patients who were older (median age: 66 years; range: 36–92 years) and who had an Eastern Cooperative Oncology Group performance status of 2 (8.9%). Despite the poorer-prognosis cohort, median overall survival was 12.0 months, which is comparable to the survival demonstrated in the randomized phase iii trials of nivolumab in lung cancer. Median time to treatment discontinuation was 3.45 months and was similar for all patient subgroups, including poorer-prognosis groups such as those with a performance status of 2, those 75 years of age and older, and those with brain metastases. Conclusions: Nivolumab given in a real-world clinical setting was associated with results similar to those reported in the phase iii clinical trial setting.
Patients with Advanced Cancer: When, Why, and How to Refer to Palliative Care Services
Authors: Courteau C. , Chaput G. , Musgrave L. , Khadoury A.
Published: February 2019

Palliative care (PC) is a fundamental component of the cancer care trajectory. Its primary focus is on “the quality of life of people who have a life-threatening illness, and includes pain and symptom management, skilled psychosocial, emotional and spiritual support” to patients and loved ones. Palliative care includes, but is not limited to, end-of-life care. The benefits of early introduction of PC services in the care trajectory of patients with advanced cancer are well known, as indicated by improved quality of life, satisfaction with care, and a potential for increased survival. In turn, early referral of patients with advanced cancer to PC services is strongly recommended. So when, how, and why should patients with advanced cancer be referred to PC services? In this article, we summarize evidence to address these questions about early PC referral: (1) What are the known benefits? (2) What is the “ideal” PC referral timing? (3) What are the barriers? (4) Which strategies can optimize integration of PC into oncology care? (5) Which communication tools can facilitate skillful introduction of PC to patients?
Nanocomposite–parylene C thin films with high dielectric constant and low losses for future organic electronic devices
Authors: Mokni Marwa , Maggioni Gianluigi , Kahouli Abdelkader , Carturan Sara M , Raniero Walter , Sylvestre Alain
Published: February 2019

Nanocomposite–parylene C (NCPC) thin films were deposited with a new technique based on the combination of chemical vapor deposition (CVD) for parylene C deposition and RF-magnetron sputtering for silver deposition. This method yields good dispersion of Ag-containing nanoparticles inside the parylene C polymer matrix. Film composition and structure were studied by using several techniques. It was found that the plasma generated by the RF-magnetron reactor modifies the film density as well as the degree of crystallinity and the size of parylene C crystallites. Moreover, silver is incorporated in the parylene matrix as an oxide phase. The average size of the Ag oxide nanoparticles is lower than 20 nm and influences the roughness of the NCPC films. Samples with various contents and sizes of silver-oxide nanoparticles were investigated by broadband dielectric spectroscopy (BDS) in view of their final application. It was found that both the content and the size of the nanoparticles influence the value of the dielectric constant and the frequency-dependence of the permittivity. In particular, β-relaxation is affected by the addition of nanoparticles as well as the dissipation factor, which is even improved. A dielectric constant of 5 ± 1 with a dissipation factor of less than 0.045 in the range from 0.1 Hz to 1 MHz is obtained for a 2.7 µm thick NCPC with 3.8% Ag content. This study provides guidance for future NCPC materials for insulating gates in organic field-effect transistors (OFETs) and advanced electronic applications.
STATISTICAL PROBABILITY EVALUATION OF OPERATION TIME OF ROAD TRANSPORT MEANS
Authors: Smičius Algimantas
Published: February 2019

One of principal factors hindering the normal process of freight transportation is the insufficient reliability of transport means (especially with the extension of operation time) and their failures caused by various reasons. The article presents the results of processing the flows of failed road transport means. The evaluation of the probability characteristics of failed vehicles is also presented.
ANALYSIS OF WEARING-OUT CAUSES FOR REVOLVING-BLADE MIXERS AND THEIR RELIABILITY IMPROVEMENT
Authors: Jurevičius Jurgis , Sivilevičius Henrikas , Spruogis Bronislovas
Published: February 2019

In road coverings and structures of transport infrastructure, composite mixes of various compositions are used made with either organic or mineral binding agents. Most often they are made in a discreet revolving-blade forced mixer, and the final product quality is subject to the mixer construction and parameters. The present paper analyzes wear causes of a revolving-blade mixer with the most important of them-sticking of grains between the blade end and the bottom. Forces are defined effecting various-sized grains found between the blade end and the mixer bottom. Mixer quality assessment methodology is presented, based on analysis principles of homogeneity dynamics for mix being made by it. It is demonstrated that construction homogeneity estimates are different for mixers with various wearing-out levels. Wearing- out of mixer elements may be reduced and mixing quality for mix may be improved by choosing the optimum distance between the blade end and the bottom fretting and changing blade metal and dimensions. Elastic centrifugal coupling is recommended to decrease transmission strokes.
CARGO FLOW AND TRANSIT IMPACTS ON PORT DEVELOPMENT
Authors: Paulauskas Vytautas , Lukauskas Valdas
Published: February 2019

The article analyses the changes of cargo flow structures, the distribution by overseas regions and their potential impact on port development. The analysis on how the cargo type and transit regions influence on the vessel capacity has been carried out. A view on the general range of ship size employed on the Baltic is given. The potential of the Klaipeda seaport is approached in respect of certain cargo flow evaluation. The tendencies of changing the main cargo flows through the Klaipeda seaport and the way they influence on ship sizes are researched. Possible influence of large-sized ship traffic on the port operations and development has been considered.
THE REVIEW OF THE MONOGRAPH “TRANSPORT SYSTEM: MODELS OF DEVELOPMENT AND FORECAST” (BY ADOLFAS BAUBLYS)
Authors: Paulauskas Vytautas
Published: February 2019

Major factors determining global economic development are the integration processes taking place now at all levels in Europe. They are aimed at the creation of the common European space.
IMPROVEMENT OF FREIGHT TRANSPORT TECHNOLOGIES AND IMPLEMENTATION OF NEW TECHNOLOGIES
Authors: Baublys Adolfas
Published: February 2019

The synthesis of regional (urban) road transport freight system topological structure enables the assessment of impact exercised by various structural characteristics on the functioning of the system. For this reason the quality of project solutions in the stage of system structural synthesis increases.

Models of optimisation and simulation (included into the simulation procedure of optimisation of topological structure) have other possibilities as well. For instance, simulation model enables the solution of such various objectives of functional analysis of systems as, for example, the efficiency comparison analysis of stability of structure undergoing the changes of meanings of system parameters, the analysis of managing impacts of various types, loading technologies, etc.
FORECASTING OF RAILWAY FREIGHT VOLUME: APPROACH OF ESTONIAN RAILWAY TO ARISE EFFICIENCY
Authors: Hunt Ülo
Published: February 2019

The local railroad was substantially deregulated and prepared for privatization by Estonian government in 90's. Changes in commodity mix, length of haul, shipment size, loading weight, equipment ownership, railroad costs, competition from other modes, and demand for railroad transportation have all played a significant role. This paper introduces the importance of forecasting a railway freight volume using the methodology of international knowledge.
THE STUDY OF THE STABILITY OF ASPHALT CONCRETE MIXTURE COMPOSITION OPTIMIZATION MATHEMATICAL MODELS USING IMITATIVE SIMULATION
Authors: Podviezko Valentinas , Sivilevičius Henrikas
Published: February 2019

The method of statistical imitative simulation (Monte-Carlo) was used to simulate the heterogeneity of the produced asphalt concrete mixture (ACM) mineral part grading. The stability of optimisation of mathematical models of ACM composition developed by us was tested by a computer using tpe theory of this method application. Average values aij and their average standard deviations σ ij of seven (Aj = 7) finally hatched aggregate partial residues on control sieves i (i = 9) were set for research. Imported filler A 1 and reclaimed dust A 2 were replaced by their mixture Ā1 when the accepted ratio of these materials masses λ is 1, 2 and 3. The maximum (A max) and minimum (A j min) values of ACM materials quantity optimal composition were calculated from numerical values of aggregate with different heterogeneity ((minimum - σ ijmin, medium - σ ijvid , maximum - σ ijmax) increasing the number of computer imitations N (100, 300, 500, 1000, 5000, 10 000). The graphs of the difference between the calculated maximum and minimum values of optimal quantity of aggregate dependence ΔAj on the imitation number N are presented. Calculation results proved the sufficient stability and practical application of the used optimization mathematical model to forecast ACM heterogeneity, when the heterogeneity and optimal quantity of the aggregate used in the mixture are known.
Mapping the conceptual structure of environmental management: a co-word analysis
Authors: Nájera-Sánchez Juan-José , Mora-Valentín Eva-María , Ortiz-de-Urbina-Criado Marta , Moura-Díez Pablo
Published: February 2019

This paper contributes to a better understanding of the research on environmental management using bibliometric methods to supplement the subjective evaluation of literature reviews. Focusing on the Management and Business fields, our main objective is to analyse the knowledge structure of environmental management literature and the evolution of related topics. We apply the co-word analysis method to identify different topics treated by the field across the studied periods, and to create networks and sub-networks. The results show the main topics and their evolution. We identify and explain six topics: green/environmental, resource-based-view, management, performance, corporate social responsibility and quality management. Development in this line of research shows progress in this discipline that commences with the green or environmental dimension and its effects on results and continues with issues that are more focused on quality management and corporate social responsibility. This study can be used as a reference for future research and help to increase company awareness of the importance of environmental issues in the design and implementation of strategies.
The effect of related party transactions on firm performance: the moderating role of political connection in indonesian banking
Authors: Supatmi Mr , Sutrisno T. , Saraswati Erwin , Purnomosidhi Bambang
Published: February 2019

This study aims to examine the effect of related party transactions (RPTs) on banks’ performance and investigates political connections as moderator in their causal relationship. Our sample is 40 Indonesian banks listed on the Indonesian Stock Exchange for the years 2013–2016 with 160 observations as panel data. Based on panel data regression test, our results demonstrate that account receivables-related RPTs have a positive effect on banks’ profitability and its market performance (Tobin’s Q), but there are consequences of high operating costs and the risk of non-performing loans. Banks receive more funds from their related parties (account payables-related RPTs), banks exhibit higher capital capability and lower market performance. Further, the political connection index in banks significantly affect banks’ capability, liquidity, efficiency, and market value through RPTs. This result indicates that political connection strengthens the effects of RPTs on banks’ performance. Although this study has limited information in determining political connections and has not considered macroeconomic conditions, these findings imply that political connection plays an important role in banks’ performance in Indonesia.
A Comprehensive Study of Three Early-type Contact Twin Binaries: CT Tau, GU Mon, and V701 Sco
Authors: Yang Yuangui , Yuan Huiyu , Dai Haifeng
Published: February 2019

Three eclipsing binaries, CT Tau, GU Mon, and V701 Sco, are early-type contact binaries with infrared excess from circumbinary matter. We present the multi-color photometry for CT Tau and GU Mon, whose spectral types of B1V are identified by the low-precision spectra. Combining these new light curves (LCs) with previously reported LCs and radial velocity curves, we perform a synthesized analysis to estimate/update the stellar absolute parameters of the three systems. Their mass ratios are close to unity (i.e., q ≃ 1), which indicates that the binary system comprising of twin components may be undergoing a slow Case A mass transfer. From the period analysis, the light–time orbit in the (O − C) curve may result from the third condense companion around the binary system although no evidence could be provided by the third light ℓ
3. From the spectral energy distribution for three binaries, the excess infrared (IR) emissions are above the photospheric emissions, which can be seen at the 22.1 μm for CT Tau and GU Mon, and 11.6 μm, 14.5 μm, and 22.1 μm for V701 Sco, respectively. This kind of infrared excess for the early-type star may be attributed to the circumbinary matter by stellar wind.
The Rise of ROME. I. A Multiwavelength Analysis of the Star–Planet Interaction in the HD 189733 System
Authors: Route Matthew
Published: February 2019

Several “hot Jupiter” host stars appear to exhibit enhanced chromospheric activity, coronal flaring, and starspot development synchronized to their planetary orbits. These effects have been attributed to tidal and/or magnetic interactions between the star and exoplanet. The best studied among such systems is HD 189733, which has previously been observed from radio to X-ray wavelengths. Here I present ∼4.75 GHz Arecibo radio telescope observations of HD 189733 during a fraction of the exoplanet orbital phase range previously associated with enhanced coronal X-ray flaring. No radio flares from the lower corona were detected. I also leverage Microvariability and Oscillations of Stars, Automated Photoelectric Telescope, and Wise photometry to measure the occurrences of minima associated with enhanced starspot activity. The phasing of these minima with the exoplanet orbit does not reveal any synchronized active region behavior. Moreover, for the first time, I combine X-ray, ultraviolet, photometric, Ca ii H and K, Hα, and radio observations of HD 189733 to conduct an extensive, holistic reexamination of stellar activity in this system. Through the presentation of new data, and by merging physical and statistical analytic approaches, I demonstrate that the previously asserted enhancements in activity, allegedly synchronized to certain exoplanet orbital phases, are likely the result of inadequately sampled intrinsic stellar activity from an active star, rather than star–planet interactions.
Galaxy Rotation Coherent with the Motions of Neighbors: Discovery of Observational Evidence
Authors: Lee Joon Hyeop , Pak Mina , Lee Hye-Ran , Song Hyunmi
Published: February 2019

We present our discovery of observational evidence for the coherence between galaxy rotation and the average line-of-sight motion of neighbors. We use the Calar Alto Legacy Integral Field Area (CALIFA) survey data analyzed with the Python CALIFA STARLIGHT Synthesis Organizer platform, and the NASA-Sloan Atlas catalog. After estimating the projected angular momentum vectors of 445 CALIFA galaxies, we build composite maps of their neighbor galaxies on the parameter space of line-of-sight velocity versus projected distance. The composite radial profiles of the luminosity-weighted mean velocity of neighbors show striking evidence for dynamical coherence between the rotational direction of the CALIFA galaxies and the average moving direction of their neighbor galaxies. The signal of such dynamical coherence is significant for the neighbors within 800 kpc from the CALIFA galaxies, for which the luminosity-weighted mean velocity is as large as 61.7 ± 17.6 km s−1 (3.5σ significance to the bootstrap uncertainty) when the angular momentum is measured at R

e
 < R ≤ 2R

e
of each CALIFA galaxy. In the comparison of the subsamples, we find that faint, blue, or kinematically misaligned galaxies show stronger coherence with neighbor motions than bright, red, or kinematically well-aligned galaxies do. Our results indicate that (1) the rotation of a galaxy (particularly at its outskirt) is significantly influenced by interactions with its neighbors up to 800 kpc, (2) the coherence is particularly strong between faint galaxies and bright neighbors, and (3) galaxy interactions often cause internal kinematic misalignment or possibly even kinematically distinct cores.
L’incertaine construction d’une identité professionnelle : les directeurs et cadres d’ESMS associatifs dans le secteur gérontologique
Authors: Malherbe Denis
Published: February 2019

La solidarité collective avec les personnes les plus âgées et les plus dépendantes constitue un défi majeur pour la société française aujourd’hui et pour les décennies à venir. Simultanément la volonté de réduire les dépenses publiques conduit les autorités à financiariser la régulation des politiques gérontologiques. Les normes de concurrence et d’efficience conditionnent désormais la pérennité des EHPAD et services de soins à domicile. Les directeurs et cadres de ces structures associatives se trouvent ainsi placés entre valeurs humanistes et conformité technocratique, animation des équipes et masse salariale bloquée, gouvernance associative et légitimité managériale... Une identité professionnelle incertaine se construit en réponse aux tensions liées en large part à la pression normative et budgétaire. Illustrée par des verbatim tirés de deux recherches-interventions, la contribution discute l’importance mais aussi la fragilité de cette construction à la lumière des analyses de Hirschman, Sainsaulieu et Dubar.
Disparités socio-spatiales d’accès à pied des personnes âgées aux services de santé au sein de la Région Rhône-Alpes
Authors: Chibane Sami Ramzi
Published: February 2019

L’accès aux équipements et services de soins de premiers recours joue un rôle déterminant pour la santé de la population et, plus particulièrement pour les personnes âgées. En France, du fait de l’existence de disparités spatiales en termes d’accès aux soins et de l’accroissement de la part de la population vieillissante, aux besoins de soins élevés et à la mobilité réduite, la question de l’accessibilité piétonne des personnes âgées aux services sanitaires se pose avec acuité. Aux grands âges, lorsque l’accès à l’automobile se complique du fait du décès du conjoint ou des processus de « déprise » liés au vieillissement, le recours à la mobilité pédestre devient incontournable pour la réalisation des programmes d’activités quotidiennes. Dans cette optique, le défi majeur pour les politiques d’aménagement et de santé réside ainsi dans leurs capacités à rendre équitable l’accès à pied des personnes âgées aux ressources sanitaires. À cet égard, l’article vise à identifier à l’échelle des 2 879 communes de la région Rhône-Alpes – délimitation des régions avant la réforme territoriale de 2015 – les différents potentiels d’accès aux ressources sanitaires (nombre de services par habitant) et d’en étudier les disparités d’une part et, à mesurer et géovisualiser (grâce aux outils SIG) les temps d’accès à pied à ces ressources d’autre part. Ce modèle constitue le premier prototype de ce type à l’échelle d’une région française. Il s’agit à la fois de proposer une méthode reproductible qui s’appuie sur des bases de données existantes et d’illustrer de manière opérationnelle l’apport de la dimension temporelle comme aide à la décision permettant ainsi la mise en place d’actions ciblées dans le cadre des politiques publiques. Pour mener à bien cette analyse des disparités spatiales, la dotation en ressources sanitaires est quantifiée à partir de la base permanente des équipements (BPE) qui recense, au niveau infra-communal de l’IRIS l’ensemble des équipements à disposition de la population française. Pour caractériser les temps d’accès à pied aux services retenus, les outils SIG ont été déployés pour la géolocalisation des différentes ressources de santé. Les résultats montrent que les personnes âgées qui habitent les centres urbains ne sont pas en sur-équipement (nombre d’ équipements par habitant). En revanche, les habitants de ces espaces ont un accès potentiel à pied aux ressources sanitaires beaucoup plus important que le reste des communes en périphérie des grandes villes, notamment les espaces périurbains, ruraux et montagnards.
Un désir non différable
Authors: Perniola Mario
Published: February 2019

Ce texte rassemble des extraits de l’ouvrage de Mario Perniola, L’instant éternel. Bataille et la pensée de la marginalité et souligne la contribution théorique de Georges Bataille à l’analyse de l’art et de son image créatrice, à travers les notions d’hétérogénéité et de négatif. L’auteur examine notamment les rapports conflictuels entre Georges Bataille et André Breton afin d’en contextualiser les points de divergence.
La part maudite des nouveaux chevaliers du monde
Authors: Sanabria Fabián
Published: February 2019

À partir de La part maudite de Georges Bataille, l’auteur souhaite montrer combien les notions symptomatiques de dilapidation et de dépense improductive sont essentielles pour comprendre les effets de diverses manifestations esthétiques et politiques de notre contemporanéité, lesquels révèlent cette part maudite de l’homme dans son expérience intérieure du monde.
Le manque et le reste Georges Bataille et la part des choses maudites
Authors: Joron Philippe
Published: February 2019

L’œuvre de Georges Bataille, de près ou de loin, traite de la problématique communicationnelle, et donc du lien qui nous unit aux êtres, aux choses et au monde. Son approche de la communication est tout à la fois littéraire, politique, philosophique, économique, sociologique, éthologique et anthropologique, dans un ordre certes négociable et selon des focales adaptables, à condition bien sûr que l’on accepte l’idée de possibles échanges transdisciplinaires entre ces perspectives.
Facing Heart Disease: A Guide for Psychiatric Clinicians
Authors: Daunis Daniel J. , Stern Theodore A.
Published: February 2019

Heart disease is a chronic condition that affects millions of people worldwide. Research has led to improvements in treatment and increased longevity for patients. Heart disease is comorbid with many psychiatric illnesses that psychiatrists encounter in everyday practice. Thus, it is important for clinicians to have a basic understanding of heart disease, and its impact on their patients and their patients' treatments. In this article, we review the basic pathophysiology, epidemiology, and treatments for heart disease, and then describe a framework for managing the affective, behavioral, and cognitive considerations for patients with heart disease. We emphasize the identification of comorbid psychiatric illnesses and symptoms that directly or indirectly result from heart disease. Finally, we outline treatment strategies to improve overall cardiac health.

[
Psychiatr Ann
. 2019;49(2):55–59.]
A Rare Case of Pediatric Lacrimal Sac: Squamous Cell Carcinoma
Authors: Meel Rachna , Surve Abhidnya , Bakhski Sameer , Kashyap Seema , Gupta Barkha , Sharma Sanjay
Published: February 2019

A case of a 6-year-old boy presenting with epiphora, medial canthal swelling, and lymphadenopathy is reported. Biopsy revealed a poorly differentiated squamous cell carcinoma. The child underwent neoadjuvant chemotherapy and showed tumor progression after a remarkable initial response. This case highlights the atypical age of presentation of potentially fatal lacrimal sac malignancy. Further, it emphasizes the importance of knowing signs of lacrimal sac malignancy among ophthalmologists treating childhood epiphora where inflammatory etiologies are most common. A high index suspicion, thorough clinical examination, and knowledge of the signs of malignancy may avoid delay in diagnosis of this rare but life-threatening malignancy.

[
J Pediatr Ophthalmol Strabismus
. 2019;56:e8–e11.]
Coexisting White and Dark Without Pressure Abnormalities Surrounding Congenital Hypertrophy of the Retinal Pigment Epithelium
Authors: Li May M. , Dalvin Lauren A. , Shields Carol L.
Published: February 2019

The authors report a case of coexisting white and dark without pressure abnormalities surrounding a small congenital hypertrophy of the retinal pigment epithelium and showing corresponding hyperreflectivity and hyporeflectivity of the ellipsoid layer on optical coherence tomography.

[
J Pediatr Ophthalmol Strabismus
. 2019;56:e5–e7.]
Evaluation of Factors Related to Prolonged Lengths of Stay for Patients With Autism With or Without Intellectual Disability
Authors: Ailey Sarah H. , Johnson Tricia J. , Cabrera Andrea
Published: February 2019

Patients with autism spectrum disorder and/or intellectual disability (ASD/ID) face unique health care challenges. In addition to hospital experiences characterized by fear and insufficient staff training, these patients have 1.5-times longer lengths of stay (LOS) than patients without ASD/ID, and 3.4% of patients with ASD/ID have prolonged LOS (i.e., ≥30 days). Little research exists on factors related to prolonged LOS of patients with ASD/ID, hindering efforts to develop and implement evidence-based practices to improve care and reduce prolonged LOS. The purpose of the current study was to describe factors related to prolonged LOS of adult patients with ASD/ID in acute care settings using a retrospective chart review of 10 patients discharged from one academic medical center. Findings indicate that health care institutions should evaluate performance with this patient population and identify evidence-based strategies to provide a safe environment for care and reduce LOS that is due to non-health care needs. [
Journal of Psychosocial Nursing and Mental Health Services, 57
(7), 17–22.]
Fertility Counseling for Adolescents
Authors: Kudesia Rashmi , Talib Hina J.
Published: February 2019

Fertility awareness, or general knowledge about one's fertility, is low in adolescents and in adult women as well. Misconceptions about reproduction contribute to high rates of unplanned pregnancy in the United States, as well as delayed childbearing and infertility. Alhough primary care providers caring for adolescents have historically focused on contraception and reduction of sexually transmitted infections during their sexual and reproductive health conversations with adolescents and young adult women, fertility awareness counseling would help these women optimize their future fertility and make informed reproductive choices throughout their life. This is particularly true for adolescents with chronic medical conditions, certain gynecologic conditions, or a history of therapies that could potentially affect fertility, for whom preemptive conversations about fertility are needed, but often overlooked.

[
Pediatr Ann
. 2019;48(2):e86–e91.]
Sexual Violence in Adolescents
Authors: Northridge Jennifer L.
Published: February 2019

Sexual violence and intimate partner violence are common among adolescents, especially for those who are developmentally disabled. Pediatricians have a critical role in treating and preventing sexual violence in adolescents. As medical providers, they possess trusted access to identify sexual violence in adolescents and to intervene to help prevent further violence and mitigate associated health effects. Therefore, it is imperative that pediatricians are aware of the scope of sexual violence in adolescents. Specific sexual violence screening recommendations for sexual assault, intimate partner violence, reproductive coercion, and sex trafficking are reviewed in this article. In addition, recommendations for the comprehensive treatment of adolescents exposed to sexual violence are examined. National and local resources for victims and promising strategies to prevent sexual violence, including sex trafficking, are identified. Through collaboration with community partners in multidisciplinary efforts, pediatricians can most effectively promote the health of adolescents and prevent further victimization.

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Pediatr Ann
. 2019;48(2):e58–e63.]
To what extent are hake fat and its oil quality affected by the parasite Lernaeocera lusci?
Authors: Telahigue K. , Rabeh I. , Chetoui I. , Bejaoui S. , El Cafsi M. , Hajji T.
Published: February 2019

The copepod Lernaeosera lusci is a common ectoparasite of the hake Merluccius merluccius, which constitutes its definitive host. The present study is the first to investigate the impact of L. lusci and its infection intensity on the fatty acid (FA) composition and oil quality of its host. The results revealed a substantial decrease in the total FA content, which dropped by 50, 70 and 83% when fish was infected by one (L1), two (L2) and three (L3) parasites, respectively. The lipid profile showed a tendency for a significant decrease in the saturated fatty acid (SFA), monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA) levels in all parasitized groups and in a parasite load dependant manner (p < 0.05). The same tendency was observed for the most commonly analysed FA and in particular for essential FA, such as e arachidonic (ARA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, which showed smaller amounts associated with L. lusci co-infection. From a nutritional standpoint, our findings revealed that L. lusci is able to cause severe deterioration in the nutritional quality of its host oil. In addition to the increase in the thrombogenicity index (IT) and the high atherogenicity index (IA) values, the low hypocholesterolemic / hypercholesterolemic fatty acid ratio (H/H) and the modest amount of DHA+EPA (20 and 10 mg/100g) recorded at heavy infection levels make the parasitized fish inadequate sources of these PUFA and unsuitable for consumers with special dietary needs.
« Je dois me saturer de Brancusi ! »
Authors: Camporesi Enrico
Published: February 2019

En 1977, lors d’une visite de l’ensemble sculptural de Târgu Jiu en Roumanie, Paul Sharits (1943-1993) tourne un documentaire sur Constantin Brancusi. Véritable hapax dans la production filmique de l’artiste américain, le film témoigne d’un intérêt marqué pour l’œuvre du sculpteur roumain qui va bien au-delà du simple régime d’influence. Cet article tâche de reconstruire, à l’aide de documents d’archives inédits, l’origine et les ramifications de cette relecture singulière d’une œuvre par un artiste. En posant son regard sur le travail de Brancusi, Sharits opère selon au moins trois axes. D’abord, il fait de la sculpture un outil théorique pour penser la mise en espace de ses installations filmiques. Ensuite, il esquisse des hypothèses de travail d’historien de l’art. Troisièmement, à travers Brancusi, il amorce un dialogue avec les artistes qui lui sont contemporains – Lynda Benglis, par exemple.
Le théâtre de la révolution guna (1925)
Authors: Madi Dias Diego
Published: February 2019

Les problématiques abordées dans cette étude du théâtre de la révolution guna ont pour origine une proposition forte d’Edmund Leach (1954), selon laquelle « il faut étudier l’esthétique d’un peuple pour en comprendre l’éthique ». L’hypothèse de travail ici est que l’esthétique du drame au sein du peuple guna constitue un objet privilégié de recherche pour la compréhension de son éthique sociale. L’objectif de l’article est d’apporter de nouveaux éléments au débat sur l’art, la politique et la mémoire sociale par le biais d’une réflexion sur le « patrimoine moral », c’est-à-dire un ensemble de valeurs à mettre en scène, affirmer, préserver et transmettre. Sur la base de l’exemple du théâtre communautaire guna, il sera possible d’envisager une définition renouvelée de l’« héritage », désignant à la fois les activités mnémonique et émotionnelle. L’approche développée dans cet article doit beaucoup à la perspective inaugurée par les études de Carlo Severi sur le chamanisme guna en tant que situation de représentation rituelle de la souffrance. Ancré dans une ethnographie des dramatisations auxquelles l’auteur a pu assister dans le village d’Uggubseni en février 2017, cet article propose une analyse du théâtre communautaire en tant que dispositif permettant la production de positions relationnelles ou d’identifications qui rassemblent le mythe, l’histoire, le rituel et la parenté à travers l’expérience de la douleur et de la souffrance. Par là, il s’agit d’entreprendre une réflexion sur le théâtre communautaire à l’aune de la théorie pragmatique du rituel proposée par Carlo Severi et Michael Houseman.
Réécrire l’histoire du peuplement de la Grande Comore à partir des sources archéologiques
Authors: Moustakim Ibrahim
Published: February 2019

Il est admis que l’écriture est le moyen de communication par excellence pour sauvegarder et transmettre les faits historiques anciens comme récents. Les écrits sur l’histoire du peuplement de la Grande Comore sont rares et récents et surtout portent divergences et contradictions car l’histoire des Comores se transmet à l’oral, de bouche-à-oreille depuis longtemps. La rareté des documents écrits et l’absence de contenu homogène montrent la nécessité de réécrire l’histoire du peuplement de l’île en exploitant d’autres sources (archéologiques) très fiables pour avoir des versions historiques homogènes, concordantes et correctes sans contradiction. Les chercheurs de l’histoire des Comores doivent employer des approches multidisciplinaires et scientifiques pour dater ou déterminer l’origine et l’époque du peuplement des Comores en général et celui de la Grande Comore en particulier.
À la recherche des identités et dynamiques sociales paléolithiques
Authors: Gaussein Pascaline
Published: February 2019

Il est particulièrement délicat de distinguer une identité culturelle relativement stable, portant en elle les traces d’une longue histoire d’interactions, et les réseaux entretenus par ces mêmes populations à un moment donné de leur histoire. D’après certains chercheurs, les analyses de répartition, de variations et constantes stylistiques opérées par les archéologues permettent plus de dessiner les interactions entre groupes humains que les contours d’identités culturelles. Dans cette perspective, en interrogeant les réalités sociales effectivement atteintes à travers les vestiges préhistoriques, cet essai méthodologique a pour ambition de repousser les limites interprétatives et d’enrichir les hypothèses et les appréhensions des comportements sociaux et culturels des populations du Paléolithique supérieur. Cette étude repose sur le fait anthropologique que la culture matérielle est partie prenante des pratiques sociales d’interactions, à la fois participative et impactée par ces comportements. Le style des objets et leur répartition dépendent donc des interactions entre individus et groupes, en lien étroit avec leur environnement naturel et social (ressources, démographie humaine, notamment). Il est donc fait appel à des récurrences anthropologiques qui fournissent des clés de lecture pour la distribution et l’évolution des styles de la culture matérielle au regard des contextes et dynamiques sociales qui en sont généralement responsables. À partir des densités humaines suggérées pour le Magdalénien, croisées avec les Magic numbers anthropologiques, des cartes théoriques de répartition des unités sociales humaines peuvent être dressées. Dans ce cadre, la distribution des traits culturels prendra automatiquement sens, d’un point de vue sociologique. Cette méthode est testée sur l’art mobilier osseux du Magdalénien moyen ancien, mis au jour entre le Seuil du Poitou et le nord du Bassin aquitain (environ 16 000 à 14 500 ans B.P.). L’approche est complétée par une discussion des résultats à partir des autres catégories de vestiges. Plusieurs scenarii peuvent se révéler plausibles, mais certains apparaissent plus adaptés au regard des données. Une approche diachronique de l’art sur support osseux suggère au moins deux principales subdivisions, marquées par une progressive densification de la population humaine. Cet essai méthodologique permet d’interroger les réalités sociales réellement approchées à travers l’art paléolithique, ainsi que d’enrichir et de multiplier nos hypothèses interprétatives et notre appréhension des comportements socioculturels des populations dites magdaléniennes. Cette étude est extraite de travaux en cours, aussi les résultats présentés dans cet article sont-ils préliminaires.
Biais archéologique, biais culturel : les anomalies du recrutement funéraire en contexte résidentiel maya
Authors: Goudiaby Hemmamuthé
Published: February 2019

Si les mayanistes ont remarqué depuis longtemps la faiblesse anormale des effectifs mis au jour dans les ensembles résidentiels mayas, rares sont les travaux qui ont tenté de l’expliquer autrement que par le raccourci un peu trop aisé qu’est le culte des ancêtres. Un simple regard au recrutement funéraire suffit pourtant à montrer qu’il ne s’agit là que d’un aspect du problème. En effet, une importante conjonction de facteurs, allant de la culture locale aux méthodes de fouille employées, s’entrecroisent pour nous livrer une image particulièrement déformée des pratiques funéraires mayas. Hélas, il n’existe pas encore de véritable solution pour démêler l’écheveau. En effet, peut-on discuter de la sélectivité relative de la culture maya vis-à-vis de ses morts sans avoir d’abord évalué la représentativité de l’échantillon, ou s’être assuré une neutralité méthodologique maximale ? Ce sont là des préoccupations relativement récentes dans le domaine mayaniste, et elles n’ont pas encore trouvé de réponse vraiment satisfaisante. À titre d’exercice autant que de démonstration, nous proposons de discuter ces différents points au travers d’une simulation sur un cas d’étude unique par bien des aspects : celui de la structure E-7 d’Altun Ha. Nous élargirons ensuite notre point de vue pour montrer comment, en fin de compte, le biais archéologique dans l’aire maya est avant tout la conséquence directe de pratiques culturelles que nous suivons peut-être trop aveuglément.
A preliminary analysis of the association between perceived stigma and HIV-related pain in South Africans living with HIV
Authors: Wadley Antonia L. , Pincus Tamar , Evangeli Michael
Published: February 2019

Background: Stigma related to the human immunodeficiency virus (HIV) remains common and has been associated with severity of HIV-related symptoms. Associations between HIV stigma and HIV-related pain, one of the most common symptoms in HIV, have however not been investigated. Data from low back pain populations suggest that stigma is associated with worse pain intensity and so we hypothesised that the same would be the case in HIV.Aim: The goal of this study was to assess the association between HIV stigma and pain intensity in people living with HIV (PLWH) with chronic pain whilst controlling for depression, a well-established correlate of pain.Setting: The study took place at an HIV clinic in Johannesburg, South Africa.Methods: Mediation analysis was used to assess the effect of depression on the relationship between stigma and pain intensity in a cross-sectional cohort of 50 PLWH and chronic pain (pain most days of the week for > 3 months). All participants were assessed using the HIV/AIDS Stigma Instrument – PLWA, an 11-point numerical pain rating scale and the Beck Depression Inventory II.Results: In all, 88% (44/50) of participants reported experiencing some form of HIV stigma (HIV stigma scale score ≥ 1). Worst pain intensity and depressive symptoms individually correlated with total stigma score (Spearman’s r = 0.33, p = 0.02 for both). The mediation analysis highlighted that mediation of the relationship by depression was equivocal (b = -0.002, bootstrapped confidence interval -0.02 to 0.00).Conclusion: Whilst these preliminary data are marginal, they do suggest that associations between HIV stigma and HIV-related pain warrant further investigation. Future study should also include potential mechanisms, which may include mediation through depression.