bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementación de Restaurante Pollería Broso y mejora de los servicios alimentarios, distrito de Lurigancho Chosica (Lima - Perú), 2021
Authors:   , Segura Valle Mahicon Magiber , Flores Ramos Ever Juvenal , Sanchez Bravo Jose Alejandro , Ramirez Albornoz Gilder Jesus
Published: June 2022

En el plan de emprendimiento es abrir una pollería denominada BROSO S.A.C especializada en la realización de los pollos a las brasas y parrillas, con ensalada verdes orgánicas. Estudiando que los pollos a la Brasa es una de las opciones más populares y como también la preferencia por la carnes asadas o parrillas va yendo en aumentando, existe un mercado que necesita ser satisfecho. Chosica considerada además de brindar productos de alta calidad que contienen, una variedad de carnes nacional e importadas y opciones de ensaladas vegetarianas orgánicas, no hay muchas posibilidades de encontrar estas dos opciones en un solo lugar. También cuenta con el servicio de primera, la rapidez y la cortesía de todos los empleados para poder resolver cualquier problema de manera oportuna, brindar un servicio personalizado y flexibilidad, satisfaciendo necesidades del consumidor de la mejor manera, brindando un ambiente agradable y brindar a los clientes seguridad e higiene. Esto genera una oportunidad de atraer clientes que no encuentran las características antes mencionadas en un solo lugar. Los ingredientes que utilizaremos para preparar el pollo a la brasa son ingredientes orgánicos, cultivados en su mayoría por agricultores de la zona, siendo responsable y contribuyendo de esta manera con la economía y desarrollo del sector. Sabiendo que las pollerías generan en su proceso bastante dióxidos de carbono CO2. Estamos viendo por políticas y cuidado del medio ambiente estamos implementación en utilizar extractoras de humo y purificadoras de aire, como también utilizar leñas y cascara de coco a fin de evitar el exceso de la contaminación con CO2, siendo principios básicos y diferenciadores en la pollería BROSO. Nuestro plan de negocio está dirigido a personas con los Niveles Socioeconómicos A y B, estamos ubicados en Chosica, lugar céntrico y de fácil acceso.
Exactitud del método de Cameriere y su variante la fórmula europea para la estimación de la edad en una población peruana subadulta - Lima 2020
Authors:   , Bravo Molina Franz Yosset
Published: June 2022

El objetivo de la presente investigación fue determinar la exactitud del método de Cameriere y su variante la Fórmula Europea en una población peruana subadulta. Se utilizaron 257 radiografías panorámicas digitales de pacientes en dentición mixta de 5 a 12 años de edad pertenecientes al Centro Odontológico “Dental Científica” de la Universidad Científica del Sur de la ciudad de Lima, Perú. Todas las variables morfológicas xi, i= 1,…,7, s, N0 y el género de los sujetos, fueron utilizadas como variables predictoras para la estimación de la edad. Para evaluar la exactitud de cada método de estimación, la edad de cada individuo fue comparada con la edad estimada utilizando el error de predicción promedio. Para poder generar la ecuación predictora de la edad cronológica se utilizó la regresión lineal múltiple. Se encontró que el error promedio de predicción entre la edad estimada por la fórmula del método de Cameriere y la edad cronológica fue 0.73±0.55 años, mientras que el error promedio de predicción entre la edad estimada por la Fórmula Europea del método de Cameriere y la edad cronológica fue 0.77±0.57 años. Se generó un modelo cuyas variables predictoras de la edad fueron el s y N0, ambas variables fueron estadísticamente significativas y el R2 Ajustado por el número de variables fue 75.96%. Se pudo determinar que la fórmula del método de Cameriere fue más exacta que la Fórmula Europea, sin embargo, no existió diferencia estadísticamente significativa entre ambas. Adicionalmente se pudo establecer una fórmula de regresión lineal específica para una población peruana de 5 a 12 años con una adecuada capacidad de predicción.
Motivación laboral y su relación con el desempeño de los colaboradores en Industrias Super Sport S.R.L. - 2021
Authors:   , Zapata Huamani Zaira Abigail
Published: June 2022

Desde la perspectiva de este estudio, el objetivo de la investigación considera “determinar la relación de la motivación laboral con el desempeño de los colaboradores en Industrias Súper Sport S.R.L. – 2021”. Dentro de la metodología se desarrolló el diseño no experimental, de enfoque cuantitativo, alcance descriptivo correlacional. La muestra fue censal y la conformaron 105 colaboradores de Super Sport. Para el recojo de datos se utilizó la encuesta como técnica, de igual forma el cuestionario como instrumento con 36 ítems para ambas variables. Para el procesamiento de datos en el entorno inferencial según la prueba de normalidad se trabajó con el estadígrafo Rho de Spearman, encontrando correlaciones positivas. Para la hipótesis general la correlación hallada fue de (r=0,764) indicando que la relación es directa y positiva, concluyendo que la motivación laboral se relaciona significativamente con el desempeño laboral de los colaboradores en Industrias Súper Sport S.R.L – 2021.
Modelo de gestión de inventario como estrategia de mejora en la competitividad de la empresa Aromatic del Perú S.A.C. Ate, 2020
Authors:   , Campos Tarazona Evelin Lesly
Published: June 2022

En la creación competitiva en que se despliegan actualmente las empresas, es muy importante desarrollar herramientas de control interno que apoyen a las compañías y organizaciones a manejar con eficiencia y eficacia sus procesos organizativos con la finalidad de disminuir sus costos para obtener superior utilidad. El trabajo estima como plan proponer un modelo de gestión de inventario para mejorar la competitividad en la empresa Aromatic del Perú S.A.C., contextualizado en la actividad como fin de determinar cuál es la incidencia en la competitividad en el mercado de la actividad comercializadora y en la rentabilidad de la empresa. Se hizo uso de método a seguir para realizar un diagnóstico a profundidad de la situación problemática antes y después de la mejora, estableciendo una propuesta sobre la base de métodos utilizando la metodología del valor agregado para la solución a la problemática y técnicas científicas de investigación y encuesta aplicadas a la totalidad de los trabajadores como muestra, contando una expresión en la esfera del manejo de los inventarios, siendo una investigación descriptiva. Los resultados conseguidos muestran los principales problemas del control de inventarios asociados a la gestión de aprovisionamiento de inventarios, el tiempo de adquisición de inventarios y la variabilidad de la demanda. Estos logros servirán como referente para futuras investigaciones en la cual se considerarán otros factores del manejo de inventarios en las empresas dedicadas a la comercialización y que permitan favorecer en crear y plantear sistemas de control para favorecer a reducir desperdicios en los procesos que incidirán en la rentabilidad de la empresa.
Humanitarian practice fit for the digital age
Authors: Jurko Ivana
Published: June 2022

This essay seeks to examine some of the implications of advanced digital technologies on the humanitarian sector. It first situates data and technology-driven transformations in the broader context of humanitarian innovation and reform. It outlines how the increasing scale and complexity of humanitarian needs and operating environments has led to experimentation with new tools and approaches, business models and organisational roles in the sector. These innovations are occurring against the background of the localisation agenda, competition from the private sector, collapsing trust in institutions, and increased scrutiny of charities. The essay then highlights how technologies such as artificial intelligence and machine learning, biometrics, and blockchain are increasing the capacity of the sector to improve humanitarian outcomes for people in crisis through new functionalities and services, greater insights into emerging vulnerabilities and risks, and enhanced organisational performance. Conversely, the essay then explores how these tools and systems are introducing a host of potential harms by exposing vulnerable people and communities to new forms of intrusion, insecurity, and inequality. This includes issues of data protection, cyber security, inherent biases in technological tools, and the reality of the digital divide and exclusion. Lastly, the essay outlines an emerging critical research agenda and active policy debates about responsible, ethical and inclusive design, use and regulation of technology in humanitarian contexts.
Autonomous Sensing Microsystem with H2S Compatible Package and Enhanced Buoyancy for Downhole Monitoring
Authors: Vellaluru Neeharika , Dutta Partha , Benken Alexander , Boero-Rollo Jean-Gregoire , Ordonez-Varela John-Richard , Gianchandani Yogesh
Published: June 2022

We report an autonomous microsystem intended for deployment in harsh fluid environments. The microsystem incorporates pressure, temperature, and inertial sensors and Bluetooth Low Energy (BLE) communication electronics; power is supplied via secondary battery, recharged using Qi wireless power transfer. Sensors and electronics are incorporated within a circuit board measuring ø26.7 × 1.5 mm3 which is embedded in a package with volume <25 cm3 and density <1200 kg/m3. The small size and density permit enhanced buoyancy control and deployment through narrow apertures. The package is comprised of a fluorocarbon elastomer VitonTM shell, which provides the necessary mechanical and chemical protection, and is filled with low bulk density cenospheres, which reduce the overall density while still allowing pressure to be transferred to the board-mounted sensor. This integration approach allows reclamation and repackaging of the electronics for rapid evaluation in a variety of harsh environments. Microsystems were tested in laboratory conditions at pressures up to 41.5 MPa and temperatures up to the battery limit of 85°C while successfully recording data for >96 hours. The VitonTM packaging was tested in H2S, diesel fuel, and 15% brine. Microsystems were then successfully evaluated in field deployment conditions in an oilwell to a depth of 1290 m, recording pressure, temperature, and inertial data.
Elevated circulating levels of phenylacetylglutamine in stroke patients with T2D are linked to specific gut microbiota
Authors: Wei Minping , Huang Qin , Yu Fang , Ying Yuanlin , Luo Yunfang , Feng Xianjing , Liao Di , Zhao Tingting , Huang Qing , Feng Jie , xia jian
Published: June 2022

Objective
Type 2 diabetes (T2D) aggravates the injury of ischemic stroke (IS). The alterations of gut microbiota and its metabolite phenylacetylglutamine (PAGln) levels in stroke patients with T2D remain unclear. Therefore, our study aimed to explore the differences in gut microbiota and its metabolite PAGln between IS patients with and without T2D.
Methods
In our study, 35 IS with T2D (IS-T2D group), 50 IS patients without T2D (IS-NT2D group), and 29 healthy controls (HC group) were recruited. Fecal samples were collected and analyzed using high-throughput sequencing of 16S rRNA genes, and plasma samples were subjected to targeted metabolomics to detect metabolite PAGln. Plasma PAGln levels of rats with transplantation of fecal microbes from patients were assessed.
Results
Our results showed that the plasma PAGln levels in IS-T2D patients were significantly higher than those in IS-NT2D patients. Correlation analysis showed that plasma PAGln levels were significantly correlated with the relative abundance of Enterobacteriaceae, Verrucomicrobiota, and Klebsiella, which were enriched in IS-T2D patients. Further studies demonstrated that plasma PAGln levels were positively correlated with the concentration of neutrophil extracellular traps (NETs), and NETs levels were increased in a dose-dependent manner according to PAGln levels. Moreover, the rats transplanted with fecal microbes from IS-T2D patients developed more severe brain injury and higher plasma PAGln levels compared to the rats transplanted with fecal microbes from IS-NT2D patients.
Conclusions
Our results suggest that T2D may contribute to aggravation in stroke patients via NETs, mediated in part by gut microbiota and its metabolite PAGln.
Multi-UAV Factor Graph Co-location Algorithm
Authors: Zhang Yuexia , Jia Pengfei
Published: June 2022

To tackle the difficulty and high cost of UAV positioning in a disaster environment, this study proposes a multi-UAV coordinated positioning algorithm based on a factor graph (MUAV-FGC). A factor graph model is designed for coordinated positioning of the master-slave UAVs. In the positioning process, the influence of the speed and heading errors of the UAV on the positioning accuracy was analyzed, and the expected and variance values of the variables were used as the information transmitted between the factors. The error of the cooperative positioning algorithm was derived based on the factor graph. The coordinated positioning of multiple drones and the positioning accuracy improved. The simulation results show that, compared with the traditional extended Kalman filter (EKF) algorithm, the proposed MUAV-FGC positioning algorithm reduces the mean positioning and root mean square error by approximately 18.86% and 17.54%, respectively, thus proving its effectiveness.
Gamification for behavior change: a scientometric review
Authors: Bassanelli Simone , Vasta Nicola , Bucchiarone Antonio , Marconi Annapaola
Published: June 2022

Gamification, which refers to the use of game design elements in non-game contexts, provides similar experiences and motivations as games do; this makes gamification a useful approach to promote positive behaviors. As a useful tool for keeping users motivated, engaged and active, there is a wide interest in adopting gamification solutions for supporting and promoting positive behaviors and behavior change (e.g. quit smoking, ecological behaviors, food choices, civic engagement, mental healthcare, sustainability, etc.). In this study, we use the CiteSpace software to examine 984 publications and their 46,609 unique references on gamification applied for behavior change. The corpus of studies was downloaded from the Scopus database and refers to studies published between 2011 and the beginning of 2022. Several methods were used to analyze these data: (1) document co-citation analysis (DCA) was performed to identify the pivotal researches and the research areas; (2) author co-citation analysis (ACA) was performed to identify the main authors; (3) and keyword analysis was performed to detect the most influential keywords and their change over time. The results of the analysis provide an overview of the influential documents, authors and keywords that have given shape to the literature of the field, and how it has evolved, showing an initial interest in motivational and persuasion techniques, and in the gamification design, and subsequently in the development of more rigorous methodologies for both design and use. As the first scientometric review of gamification applied to behavior change, this study will be of interest to junior and senior researchers, graduate students, and professors seeking to identify research trends, topics, major publications, and influential scholars.
Integrating Vernier Spectrum With Fano Resonance for High Sensitivity of All-optical Sensor
Authors: Aman Mohammad Amirul Hairol , Noorden Ahmad Fakhrurrazi Ahmad , Fajri Faris Azim Ahmad , Kadir Muhammad Zamzuri Abdul , Bahari Iskandar , Danial Wan Hazman , Daud Suzairi , Bahadoran Mahdi
Published: June 2022

Vernier and Fano resonances are promising approaches for enhancing the sensitivity of an alloptical sensor. A theoretical analysis was performed to integrate a Fano-like resonance shape with a Vernier resonance by considering the presence of partial reflective end facets at a double microring resonator waveguide. The system was developed based on scattering matrix and optical transfer function. The double and all-pass racetrack microring configurations were compared with and without the end facet at the waveguide to analyze the dynamic change of the output resonance spectrum. The spectrum were analyzed based on the free spectral range and resonance pattern. The resonator systems were applied to refractive index-based sensing protocol, which was operated by a shift of resonance wavelength with a change of refractive index. The sensitivity was optimized by varying the configuration parameters such as the radius of the ring, the distance between end facet, and the coupling coefficients. Integrating Vernier spectrum with Fano resonance improved the sensitivity for all-pass racetrack configuration by 5.16% and the sensitivity for double racetrack configuration by 6.31%. The recorded limit of detection (LOD) of double racetrack was 3.30 × 10 -5 .
Self-recycling and partially conservative replication of mycobacterial methylmannose polysaccharides
Authors: Maranha Ana , Costa Mafalda , Ripoll-Rozada Jorge , Manso Jose , Miranda Vanessa , Mendes Vera , Manadas Bruno , Macedo-Ribeiro Sandra , Ventura Rita , Pereira Pedro José Barbosa , Empadinhas Nuno
Published: June 2022

The steep increase in nontuberculous mycobacteria (NTM) infections makes understanding their unique physiology an urgent health priority. NTM synthesize two polysaccharides proposed to modulate fatty acid metabolism: the ubiquitous 6-O-methylglucose lipopolysaccharide, and the 3-O-methylmannose polysaccharide (MMP) only detected in rapidly growing mycobacteria. The recent identification of a unique MMP methyltransferase implicated the adjacent genes in MMP biosynthesis. We report a wide distribution of this gene cluster in NTM, including slowly growing mycobacteria, which we reveal to produce MMP. Using a combination of MMP purification and chemoenzymatic syntheses of intermediates, we identified the biosynthetic mechanism of MMP, relying on two enzymes that we characterized biochemically and structurally: a unique α–endomannosidade that hydrolyses MMP into defined-sized mannoligosaccharides that prime the elongation of new daughter MMP chains by a rare α-(1>4)-mannosyltransferase. Therefore, MMP biogenesis occurs through a partially conservative replication mechanism, and disruption of the mechanism affected mycobacterial growth rate at low temperature.
Exploring the Relationship between socioeconomic attributes and resilience capacity of Murrah buffalo-based livestock production system in changing climatic scenario
Authors: Singh Ruchi , Maiti Sanjit , Garai Sanchita , Bhakat Mukesh , Dixit A K , Aggarwal Anjali , Gour Anil Kumar , Kadian KS
Published: June 2022

The present study was conducted in farming community who reared specifically Murrah buffalo in their livestock production system for their livelihood. Total 320 Murrah buffalo farmers from 4 district of Trans-Gangetic Plain Region of India were identified and data collected through focused group discussion, PRA tools and face to face interview to measure the resilience capacity and their socioeconomic variables. Statistical tools such as ‘Principal component analysis’ for index development, cumulative square root methods for categorization of respondents and regression analysis were performed for exploring relationship. Result depicted that majority of the farmers have medium level of climate resilience index score i.e. 0.456. Moreover, it was found that farmer’s involvement in social institute such as, gram panchayat, agriculture and dairy co-operative society, self-help group, farmers’ association etc. were effect the resilience capacity of the respondents in changing climatic scenario. Whereas, farmers for seeking information on government subsidies/schemes rely more on village level worker, agriculture development officer, veterinary officer, bank personnel, co-operative official, krishi vigyan kendra scientists, progressive farmers and local money lenders as these provide social safety nets as they are able to provide on time information as sources of adaptation options regarding various climate resilient practices towards climate change. The need for better technology inclusion and access to more formal systems of finance is necessary to increase the overall resilience capacity of households. However, the perceived significance of different indicators of resilience capacity was different across different categories of farming system in different areas.
China's low-carbon economic growth: An empirical analysis based on the combination of parametric and nonparametric methods
Authors: Xiu Jing , Zang Xiaoqiang , Piao Zhenggang , Li Liang , Kim Kwansoo
Published: June 2022

As the world's most populous developing country and the world's largest carbon emitter, China has already completed its 2020 Intended National Determined Contribution set out in the Paris Agreement. It achieved this result by adopting a dual goal strategy of economic growth and reducing carbon emission intensity, that is, low-carbon growth. Based on both parametric and nonparametric methods, quantitative and qualitative conclusions about China's low-carbon growth are presented. It is found that since the beginning of this century, China has maintained an annual growth performance of 1% in low carbon Total Factor Productivity (TFP) and low carbon technological progress rate. The Eastern region has leading advantages in low-carbon TFP, low-carbon technology advancement, low-carbon efficiency, and low-carbon technology leadership. It has the potential to be the first to reach its CO2 turning point. The inefficiency ratio of labor and CO2 is higher at the national level and in the Eastern region, with the two accounting for about seven-tenths and eight to nine-tenths, respectively. The difference is that at the national level, the input-output inefficiency is similar, and the inefficiency in the Eastern region is more from the input side, about eight tenths. At the present stage, China is still lenient in the implementation of low-carbon environmental regulations. In the future, the adjustment of low-carbon policy should pay attention to regional heterogeneity, focus on reducing labor and CO2 inefficiency, and be more stringent in policy implementation.
Efficacy and safety of voriconazole in the treatment of invasive pulmonary aspergillosis in patients with liver failure: study protocol for a randomized controlled clinical trial
Authors: Yu Xue , Xu Lejia , Zheng Jiaxing , Lei Ziying , Pang Yihua , Li Xiaojie , Zhu Jianyun , Liu Jing
Published: June 2022

Background: Acute-on-chronic liver failure (ACLF) is a common clinical type of liver failure, and patients with acute-on-chronic liver failure are prone to fungal infections, especially the increasing incidence of invasive pulmonary aspergillosis(IPA). Voriconazole is recommended as the first-line antifungal agent in the treatment of invasive aspergillosis, however, no recommendation has been given for patients with severe liver cirrhosis (Child-Pugh C) and liver failure. This trial aims to examine the therapeutic effects and safety of voriconazole in the treatment of IPA in patients with liver failure.Methods: This study is a non-double-blind randomized controlled trial. The 96 eligible acute-on-chronic liver failure patients complicated with invasive pulmonary aspergillosis will be randomly assigned to receive either the optimized voriconazole regimen or the recommended voriconazole regimen for patients with mild to moderate liver cirrhosis (Child-Pugh A and B), at a 1:1 ratio, with an 8-week follow-up period. The antifungal efficacy of voriconazole will be the primary outcome measure. Plasma voriconazole concentration; the laboratory examination(CRP, PCT, ESR, etc.); chest CT; adverse events; and mortality at week 4 and 8 will be the secondary outcome measures.Discussion: This trial aims to demonstrate the efficacy and safety of voriconazole in the treatment of IPA in patients with liver failure, which is expected to provide a reference for scientific optimization of voriconazole regimens and a realistic basis for the standardized treatment of acute-on-chronic liver failure patients complicated with invasive pulmonary aspergillosis.Trial registration: The trial was registered with the Chinese Clinical Trial Registry, ChiCTR2100048259. Registered on 5 July 2021.
The first cellulose/bentonite doped vanadium from natural bentonite and wheat wastes for oxidation of sulfur compounds
Authors: Naeimi Atena , Ardakani Mehdi Hatefi
Published: June 2022

A novel nanocomposite based on extracted cellulose from wheat wastes and natural bentonite was fabricated. Cellulose and bentonite were attached covalently (Cell/Bent composite) and vanadium complex was immobilized on it to have Cell/Bent@V Complex nanocomposite. It was further evaluated by SEM, TEM, ICP, AFM, XRD, XPS, and FT-IR. Catalytic activity of Cell/Bent@V Complex nanocomposite was evaluated on the oxidation of sulfides and oxidative coupling of thiols. The excellent conversion and selectivity were obtained for oxidation of sulfides to corresponding sulfoxides as a sole product and oxidative coupling of thiol to corresponding disulfides. The SEM, XRD, and FT-IR of recycled and reused catalyst were shown the high stability and activity of Cell/Bent@V Complex nanocomposite.
Treatment with aripiprazole once-monthly injectable formulation is effective in improving symptoms and global functioning in schizophrenia with and without comorbid substance use – A post hoc analysis of the ReLiAM study
Authors: Margolese Howard , Boucher Matthieu , Therrien Francois , Clerzius Guerline
Published: June 2022

Background: ReLiAM, Real-Life Assessment of Abilify Maintena, was the first reported long-term prospective non-interventional study for patients with schizophrenia treated with aripiprazole once-monthly injectable formulation (AOM) under real-life conditions. ReLiAM’s primary aim was to evaluate the evolution of global functional status in patients treated with AOM for 12 months in Canada. Methods: The objective of this post hoc analysis of the ReLiAM study is to investigate the treatment effects of real-life use of AOM over a 1-year period in the subgroup of patients with reported substance use compared with patients without substance use. Results: The results of this post hoc analysis demonstrate that treatment with AOM for 12 months in patients with schizophrenia was comparably effective in improving global functioning in subgroups of patients with and without concomitant substance use. Conclusions: These results support the use of AOM for the treatment of schizophrenia in patients with or without concomitant substance use.Trial registration: NCT02131415 on ClinicalTrials.Gov
An Autonomous Frequency Control Mechanism for Multi-Area Microgrids Incorporating with Distributed Energy Resources
Authors: YILDIZ Süleyman , Gunduz Hasan , Yildirim Burak , Ozdemir Mahmut Temel
Published: June 2022

Due to the intermittent nature of distributed energy resources (DER) utilised in power grids, considerable frequency variations arise when the capacity of the load frequency control (LFC) system is inadequate to correct for electricity generation and consumption imbalances. This issue may significantly increase when the microgrid is operating in isolated mode. Meanwhile, hydrogen-fuel cells are gaining traction as distributed energy storage units, assisting in the transition to a low or zeroemissions while also providing for greater operational flexibility with maintaining frequency stability. Nevertheless, power grids constantly face various uncertainties. To mitigate these uncertainties, this study purposes a new dual-input interval type-2 fuzzy fractional order PI-PD (DIT2-FPI-FPD) cascade controller with recently developed Improved-Salp Swarm Algorithm (I-SSA) for LFC of multi-area microgrids incorporating with various DER. The simulations are performed with real-time sun/wind data and genuine random load changes. Robustness of the proposed controller has been verified by sensitive case studies, which are showing the proposed controller is optimal and highly efficient.
Study on the influence of keratinized mucosa on the evolution of non-surgical peri-implant treatment in implants with peri-implantitis
Authors: Fons-Badal Carla , Panadero Rubén Agustín , Labaig-Rueda Carlos , Solá-Ruiz Maria Fernanda , García-Selva Marina , Font Antonio Fons
Published: June 2022

The main objective of this study was to evaluate the response to treatment in implants with peri-implantitis depending on the presence or absence of keratinized mucosa. Materials and Methods: 100 implants with peri-implantitis were treated non-surgically at the Prosthodontics and Occlusion Teaching Unit of the University of Valencia. Records were registered at day zero (recession, bleeding on probing, suppuration, probing depth, bone loss and plaque index), at 1, 3 and 6 months. Results: In both groups a slight increase in recession and disappearance of suppuration took place, and no bone loss was observed during the 6 months. However, both probing depth, bleeding on probing and plaque index, after an initial reduction, increased again in the group without keratinized mucosa (KM). Conclusions: Implants with KM presented better results after non-surgical treatment as well as in their medium-term evolution, although it would be advisable to increase the number of samples in order to achieve greater scientific evidence and standardization in the treatment protocol. Clinical relevance: The role of keratinized mucosa in the development of peri-implantitis has been mentioned in many publications, but less has been emphasized regarding its influence on the success of the treatment of this pathology. The presence of keratinized mucosa has been found to play a determinant role in the evolution of non-surgical treatment of peri-implantitis. The amount of keratinized mucosa should be considered in the treatment of peri-implantitis, as well as when planning connective tissue grafts accompanying the decontamination of implants in the absence of keratinized mucosa.
Safety of online MR-based adaptive ultra-hypofractionated radiotherapy for prostate cancer in China: Preliminary analysis of data from a phase II trial
Authors: Lu Ning-Ning , Han Su-Jun , Tian Yuan , Qin Shi-Rui , Guan You-Yan , Wang Dong , Xiao Ze-Jun , Shou Jian-Zhong , Xiao Zhen-Dong , Song Yong-Wen , Xia Wen-Long , Yan Ling-Ling , Xing Nian-Zeng , Li Ye-Xiong
Published: June 2022

Background This study aimed to evaluate the feasibility and safety of online adapt-to-shape (ATS) workflow for prostate cancer patients on 1.5-T MR linac in China. Methods This prospective phase II study enrolled patients with localized or oligometastatic prostate cancer. Ultra-hypofractionated radiotherapy (UHF-RT) with dose of 36.25-40 Gy in five fractions was delivered every other day. After each fraction, feasibility and tolerability of the treatment were assessed. The primary endpoints were acute grade 2 or above genitourinary (GU) and gastrointestinal (GI) toxicities after up to 12 weeks follow-up. Results From March 2021 to November 2021, 26 patients were enrolled (23 with localized prostate cancer, 3 with oligometastatic prostate cancer). For all fractions, the online ATS plans met the dose criteria for both the target volume and normal tissues. The median on-couch time was 55 (34–95) minutes and 39 (24–50) minutes with T2WI 6-minute sequence and 2-minute sequence scans, respectively. For 98.4% fractions, treatment was well tolerated. Twenty-four patients completed treatment and were followed-up for at least 2 weeks. Grade 2 or above GU and GI toxicities occurred in 33.3% and 8.3% patients, respectively; two patients had RTOG grade 3 GU toxicity (hourly nocturia). IPSS remained unchanged during UHF-RT, increased from week 2 (mean, 9.1) to week 4 (mean, 12.4), and then gradually decreased at week 6. Patient-reported urinary and bowel scores were consistent with IPSS. Conclusions UHF-RT with ATS workflow is well tolerated by patients with localized and oligometastatic prostate cancer, with only moderate GU and mild GI toxicities. Trial Registration: NCT05183074, ChiCTR2000033382
Making visible the cost of informal caregivers’ time in Latin America: a case study for major cardiovascular, cancer and respiratory diseases in eight countries
Authors: Espinola Natalia , Pichon-Riviere Andrés , Casarini Agustín , Alcaraz Andrea , Bardach Ariel , Cairoli Federico Rodriguez , Augustovski Federico , Palacios Alfredo
Published: June 2022

Background: Informal care is a key element of health care and well-being for society; however it is scarcely visible and studied in economic evaluations of healthcare. This study aims to estimate the use time and cost of informal care associated with cardiovascular diseases, pneumonia and ten different cancers in eight Latin American countries (Argentina, Brazil, Chile, Colombia, Costa Rica, Ecuador, Mexico and Peru). Methods: The good proxy approach was used to estimate the monetary value of informal care. To estimate the use of time, a compilation of data from an exhaustive literature review and econometric estimation was carried out. This data was validated through a survey of professional caregivers and interviews with experts. The national household surveys databases were processed to obtain the average wage per hour of a proxy of informal caregiver. Estimates are expressed in 2020 US dollars. Results: The study estimates approximately 1,900 million hours of informal care annually and $ 4,300 million per year in average use time cost for these fifteen diseases and eight countries analyzed. Cardiovascular diseases accounted for an informal care burden that ranged from 374 to 555 hours per year, while cancers varied from 512 to 1,825 hours per year. The informal care cost on GDP varied from 0.26% (Mexico) to 1.38% (Brazil), with an average of 0.82% in the eight Latin American countries. The cost of informal care time represents between 16% and 44% of the total economic cost (direct medical and informal care cost) associated with health conditions. Conclusions: The study shows that there is a significant informal care economic burden in different chronic and acute diseases in Latin American countries. The study highlights the relevance of including the economic value of informal care in the economic evaluations of healthcare.
The rich meteorology of Jezero crater over the first 250 sols of Perseverance on Mars
Authors: Rodriguez-Manfredi Jose , Juarez Manuel de la Torre , Sanchez-Lavega Agustin , Hueso Ricardo , Martinez German , Lemmon Mark , Newman Claire , Munguira Asier , Hieta Maria , Tamppari Leslie , Polkko Jouni , Toledo Daniel , Sebastian Eduardo , Smith Michael , Jaakonaho Iina , Genzer Maria , de Vicente-Retortillo Alvaro , Viudez-Moreiras Daniel , Ramos Miguel , Saiz-Lopez Alfonso , Lepinette Alain , Wolff Michael , Sullivan Robert , Gómez-Elvira Javier , Apestigue Victor , Conrad Pamela , Río-Gaztelurrutia T. del , Murdoch Naomi , Arruego Ignacio , Banfield Donald , Boland Justin , Brown Adrian , Ceballos Joaquin , Dominguez-Pumar Manuel , Espejo Servando , Fairen Alberto , Ferrandiz Ricardo , Fischer Erik , Garcia-Villadangos Miriam , Gimenez Silvia , Gomez-Gomez Felipe , Guzewich Scott , Harri Ari-Matti , Jimenez Juan , Jimenez Vicente , Makinen Teemu , Marin-Jimenez Mercedes , Martin-Rubio Carolina , Martin-Soler Javier , Molina Antonio , Mora-Sotomayor Luis , Lopez Sara Navarro , Peinado Veronica , Perez-Grande Isabel , Pla-Garcia Jorge , Postigo Marina , Prieto-Ballesteros Olga , Rafkin Scot , Richardson Mark , Romeral Julio , Romero Catalina , Savijärvi Hannu , Schofield John , Torres Josefina , Urqui Roser , Zurita Sofia , team MEDA
Published: June 2022

Perseverance's Mars Environmental Dynamics Analyzer (MEDA) is collecting data at Jezero Crater, characterizing the physical processes in the lowest layer of the atmosphere as no previous instrument did before. Here we show that temperature measurements at four heights capture the response of the atmospheric surface layer to multiple phenomena. We observe the transition from a stable nighttime thermal inversion to a diurnal, highly turbulent convective regime, with large vertical thermal gradients, and where local surface properties (such as Thermal Inertia) play an essential role. Recording multiple daily optical depths yielded higher aerosol concentrations in the morning than in the afternoon. Measured wind patterns are mainly driven by local topography, with a small contribution from regional winds. Daily and seasonal variability of relative humidity shows a complex hydrologic cycle. These observations raise new puzzles in which changes in surface albedo and thermal inertia may play an influential role. On a larger scale, surface pressure shows typical signatures of gravity waves and baroclinic eddies in a part of the seasonal cycle characterized before as low wave activity. These observations, combined and simultaneous, show the rich Jezero’s meteorology, and unveil the diversity of processes driving change on today’s Martian surface.
Design and Research of Form Controlled Planar Scaling Mechanism based on 4D Printing Technology
Authors: Zhang Wencai , Ge Zhenghao , Li Duanling
Published: June 2022

Structural members and kinematic pairs made of rigid materials can be flexibly used in practical applications and obtain shape-changing mechanisms. However, it also leads to a relatively complex mechanical structure and overmuch kinematic pairs, which increases the difficulty of controlling the mechanism and thus limits its application. The emergence of 4D printing technology and smart materials provides new ideas for simplifying shape-changing mechanism structure and innovation. Although smart materials are already being used in many types of mechanisms, they are almost always unique cases. How to organically combine with a specific mechanism, innovate the type of mechanism, and systematically research from structural design to deformation control is still a blank area. Therefore, this paper designs a type of novel mechanism consisting of an angulated scissor unit and a form-controlled unit, the form-controlled planar scaling mechanism, which can achieve drivable self-adjustment of size ratio under predetermined thermal stimulation. The shape-changing mechanism is thus extended to a form-controlled mechanism. This mechanism's construction method and structural principles are analyzed, and the critical structural design parameters required for deformation control are derived. Based on the above research, the core form-controlled unit that controls the deformation of this type of mechanism is designed structurally and extended to deformation control research. Finally, two sets of prototype machines are manufactured and verified the feasibility of the construction method and deformation control scheme and the correctness of the theoretical analysis. This type of mechanism promotes the innovation of mechanism design methods. It shows many application prospects in satellite deployment structures and space probe walking systems.
A Psychometric Examination of Persian Self-Care Activities Screening Scale (SASS-14) during COVID-19
Authors: Rahmani Rasol , Rostamian Morteza ,   3.	Fatemeh Mohammadzadeh, Rahmani Mohamad Reza , moghadam Fatemeh yaghoobi
Published: June 2022

Introduction: Self-care is an important and valuable principle in today's society due to its emphasis on the active role of individuals in maintaining their health. This study aims to investigate the psychometric properties of the Persian version of the Self-Care Activities Screening Scale (SASS-14) during COVID-19.Methods: After obtaining the written permission, SASS-14 was translated into Persian from the original English version. A convenient sampling of 400 Iranian people from March to November 2021 completed the online Persian questionnaire through social media. The construct validity evaluated via Explanatory Factor Analyses (EFA) and confirmed using Confirmatory Factor Analysis (CFA). The convergent validity was evaluated using Spearman correlation coefficients between the SASS-14 and Satisfaction With Life Scale (SWLS) and 36-Item Short-Form Health Survey (SF-36). It’s reliability was assessed through internal consistency and test-retest intra-class correlation coefficient (ICC). Results: The results of the present study showed that the Persian version of the scale (SASS-14) has the desired content and construct validity for use in Iranian society as the original scale. All items of the questionnaire obtained CVR scores greater than 0.62 and only two items were revised for CVI value. The results of the CFA confirmed the structure of the four-factor model with 14 items, and the indices of model fit showed that the model was sufficiently consistent with the data. Moreover, Cronbach's alpha coefficient and ICC values indicate a desirable level of internal consistency and test-retest reliability.Conclusion: The results of the study showed that the Persian SASS-14 scale enjoys good reliability and validity. This scale is useful for assessing the self-care activities in Iranian people during COVID-19.
Spatial-ID: a cell typing method for spatially resolved transcriptomics via transfer learning and spatial embedding
Authors: Shen Rongbo , Liu Lin , Wu Zihan , Zhang Ying , Yuan Zhiyuan , Guo Junfu , Yang Fan , Zhang Chao , Chen Bichao , Liu Chao , Guo Jing , Fang Guozhen , Zhang Yong , Li Yuxiang , Xu Xun , Yao Jianhua
Published: June 2022

Spatially resolved transcriptomics (SRT) provides the opportunity to investigate the gene expression profiles and the spatial context of cells in naive state. Cell type annotation is a crucial task in the spatial transcriptome analysis of cell and tissue biology. In this study, we propose Spatial-ID, a supervision-based cell typing method, for high-throughput cell-level SRT datasets that integrates transfer learning and spatial embedding. Spatial-ID effectively incorporates the existing knowledge of reference scRNA-seq datasets and the spatial information of SRT datasets. A series of quantitative comparison experiments on public available SRT datasets demonstrate the superiority of Spatial-ID compared with other state-of-the-art methods. Besides, the application of Spatial-ID on a SRT dataset with 3D spatial dimension measured by Stereo-seq shows its advancement on the large field tissues with subcellular spatial resolution.
External demands differences between roles in semi-professional soccer players during different physical activity tasks
Authors: Pillitteri Guglielmo , Giustino Valerio , Petrucci Marco , Rossi Alessio , Bellafiore Marianna , Thomas Ewan , Bianco Antonino , Palma Antonio , Battaglia Giuseppe
Published: June 2022

Background: Global Positioning System (GPS) devices are widely used in soccer for monitoring external load indicators (ELi) with the aim of maximizing sports performance, while potentially reducing the risk of injury. The aim of this study was to investigate the ELi differences in players of different playing positions (i.e., central backs, external strikers, fullbacks, midfielders, strikers, wide midfielder) and among different sport-specific tasks.Methods: 1932 observations from 28 semi-professional soccer players (FC Palermo, Italy, age: 25±6 years, height: 183±6 cm, weight: 75.2±7 kg) were collected through GPS devices (Qstarz BT-Q1000EX, 10 Hz) during the season 2019-2020. Participants were monitored during Official Match (OM), Friendly Matches (FM), Small Sided Games (SSG), and Match-Based Exercises (MBE). Metabolic (i.e., metabolic power, percentage of metabolic power > 35w, number of intense actions per minute, distance per minute, passive recovery time per minute) and neuromuscular indicators (i.e., percentage of intense accelerations, percentage of intense decelerations, change of direction per min > 30°) were recorded during each task.Results: ANOVA showed significant differences in ELi between player positions within each task and between tasks (p <0.05). Conclusion: In semi-professional soccer players, different ELis were detected for players’ positions showing the highest values during OM. Coaches should consider the different physical responses to different physical tasks and player position to design the most appropriate training program.
Adequacy of resin composites light curing: A survey on Current Awareness and Practice Among General Dentists in Saudi Arabia
Authors: Haridy Rasha , Abdalla Moamen , Alkhalaf Rana , Albishri Rana , Alenizy Anwar , Zeeshan Mohammad , Alsheikh Rasha , Aldegheishem Alhanoof , Elgezawi Moataz
Published: June 2022

Background: This study aimed to assess the current awareness and practices of resin composite light curing of general dental practitioners (GDP) in Saudi Arabia. Methods: A population of 250 general dentists appointed in non-university governmental hospitals in five main cities in Saudi Arabia was targeted with a sample size of 152 at 95% power. 250 email invitations were sent individually to join the survey voluntarily and anonymously. Descriptive statistics and Chi-square test were used to analyze the obtained responses. Results: 156 responses were received. Chi-square test showed no statistical significance in participants satisfaction of their employed light curing technique regardless of the curing unit they use. Participants vary regarding their awareness of the significance and criteria of proper light curing and resin composite material related factors. Conclusion: There is no uniform light curing technique followed by dentists. Dentists need to improve their knowledge and clinical skills of light curing resin composite.
Larval digestive system ontogeny and early weaning in neon tetra Paracheirodon innesi
Authors: Lipscomb Taylor N , Yanong Roy P , Ramee Shane W , DiMaggio Matthew A
Published: June 2022

The intensive culture of characid teleosts for ornamental trade is highly dependent on live feed organisms, particularly Artemia nauplii, to provide nutrition through the larval stage. Live feeds have inherent disadvantages relative to prepared microparticulate diets (MDs), specifically availability, labor and cost. In this research, the dependence of larval Paracheirodon innesi on live Artemia was confirmed via a dietetics trial. Next, digestive system ontogeny was characterized from the onset of exogenous feeding through metamorphosis. P. innesi exhibited an agastric larval stage, as well as low digestive enzyme activity at the onset of exogenous feeding followed by abrupt increases in trypsin, lipase and pepsin activity. Differentiation of the stomach, including gastric gland formation and production of neutral mucopolysaccharides, as well as the onset of pepsin activity, did not occur until 20 days post hatch (dph). This shift from agastric to gastric digestive modes is indicative of a proliferation of digestive capacity and subsequent prey diversity in other fish species exhibiting similar altricial larval stages. Based on this information, different schedules for weaning from Artemia to a MD were evaluated. For P. innesi fed until 32 dph, weaning beginning at 12 dph and 17 dph resulted in similar survival to live Artemia (mean: 22.0 ± 1.7%), and the MD resulted in the lowest survival (0.8 ± 0.3%). These results indicate that weaning is possible prior to gastric differentiation, potentially resulting in the reduction of Artemia use in the larval culture P. innesi.