bluuebunny/crossref_metadata_2025 huggingface dataset:
THINKING ABOUT BACTERIAL POPULATIONS AS MULTICELLULAR ORGANISMS
Authors: Shapiro James A.
Published: July 2002

▪ Abstract  It has been a decade since multicellularity was proposed as a general bacterial trait. Intercellular communication and multicellular coordination are now known to be widespread among prokaryotes and to affect multiple phenotypes. Many different classes of signaling molecules have been identified in both Gram-positive and Gram-negative species. Bacteria have sophisticated signal transduction networks for integrating intercellular signals with other information to make decisions about gene expression and cellular differentiation. Coordinated multicellular behavior can be observed in a variety of situations, including development of E. coli and B. subtilis colonies, swarming by Proteus and Serratia, and spatially organized interspecific metabolic cooperation in anaerobic bioreactor granules. Bacteria benefit from multicellular cooperation by using cellular division of labor, accessing resources that cannot effectively be utilized by single cells, collectively defending against antagonists, and optimizing population survival by differentiating into distinct cell types.
DNA Segregation in Bacteria
Authors: Gordon Gideon Scott , Wright Andrew
Published: July 2002

▪ Abstract  Segregation of DNA in bacterial cells is an efficient process that assures that every daughter cell receives a copy of genomic and plasmid DNA. In this review, we focus primarily on observations in recent years, including the visualization of DNA and proteins at the subcellular level, that have begun to define the events that separate DNA molecules. Unlike the process of chromosome segregation in higher cells, segregation of the bacterial chromosome is a continuous process in which chromosomes are separated as they are replicated. Essential to separation is the initial movement of sister origins to opposite ends of the cell. Subsequent replication and controlled condensation of DNA are the driving forces that move sister chromosomes toward their respective origins, which establishes the polarity required for segregation. Final steps in the resolution and separation of sister chromosomes occur at the replication terminus, which is localized at the cell center.

In contrast to the chromosome, segregation of low-copy plasmids, such as Escherichia coli F, P1, and R1, is by mechanisms that resemble those used in eukaryotic cells. Each plasmid has a centromere-like site to which plasmid-specified partition proteins bind to promote segregation. Replication of plasmid DNA, which occurs at the cell center, is followed by rapid partition protein-mediated separation of sister plasmids, which become localized at distinct sites on either side of the division plane.

The fundamental similarity between chromosome and plasmid segregation—placement of DNA to specific cell sites—implies an underlying cellular architecture to which both DNA and proteins refer.
SLEEP AND AROUSAL: Thalamocortical Mechanisms
Authors: McCormick David A. , Bal Thierry
Published: July 2002

▪ Abstract  Thalamocortical activity exhibits two distinct states: (a) synchronized rhythmic activity in the form of delta, spindle, and other slow waves during EEG-synchronized sleep and (b) tonic activity during waking and rapid-eye-movement sleep. Spindle waves are generated largely through a cyclical interaction between thalamocortical and thalamic reticular neurons involving both the intrinsic membrane properties of these cells and their anatomical interconnections. Specific alterations in the interactions between these cells can result in the generation of paroxysmal events resembling absence seizures in children. The release of several different neurotransmitters from the brain stem, hypothalamus, basal forebrain, and cerebral cortex results in a depolarization of thalamocortical and thalamic reticular neurons and an enhanced excitability in many cortical pyramidal cells, thereby suppressing the generation of sleep rhythms and promoting a state that is conducive to sensory processing and cognition.
PREMOTOR AND PARIETAL CORTEX: Corticocortical Connectivity and Combinatorial Computations
Authors: Wise Steven P. , Boussaoud Driss , Johnson Paul B. , Caminiti Roberto
Published: July 2002

▪ Abstract  The dorsal premotor cortex is a functionally distinct cortical field or group of fields in the primate frontal cortex. Anatomical studies have confirmed that most parietal input to the dorsal premotor cortex originates from the superior parietal lobule. However, these projections arise not only from the dorsal aspect of area 5, as has long been known, but also from newly defined areas of posterior parietal cortex, which are directly connected with the extrastriate visual cortex. Thus, the dorsal premotor cortex receives much more direct visual input than previously accepted. It appears that this fronto-parietal network functions as a visuomotor controller—one that makes computations based on proprioceptive, visual, gaze, attentional, and other information to produce an output that reflects the selection, preparation, and execution of movements.
SENSE AND THE SINGLE NEURON: Probing the Physiology of Perception
Authors: Parker A. J. , Newsome W. T.
Published: July 2002

▪ Abstract  The newly defined field of cognitive neuroscience attempts to draw together the study of all brain mechanisms that underlie our mental life. Historically, the major sensory pathways have provided the most trustworthy insights into how the brain supports cognitive functions such as perception, attention, and short-term memory. The links between neural activity and perception, in particular, have been studied revealingly in recent decades. Here we review the striking progress in this area, giving particular emphasis to the kinds of neural events that underlie the perceptual judgments of conscious observers.
Maternal Care, Gene Expression, and the Transmission of Individual Differences in Stress Reactivity Across Generations
Authors: Meaney Michael J
Published: July 2002

▪ Abstract  Naturally occurring variations in maternal care alter the expression of genes that regulate behavioral and endocrine responses to stress, as well as hippocampal synaptic development. These effects form the basis for the development of stable, individual differences in stress reactivity and certain forms of cognition. Maternal care also influences the maternal behavior of female offspring, an effect that appears to be related to oxytocin receptor gene expression, and which forms the basis for the intergenerational transmission of individual differences in stress reactivity. Patterns of maternal care that increase stress reactivity in offspring are enhanced by stressors imposed on the mother. These findings provide evidence for the importance of parental care as a mediator of the effects of environmental adversity on neural development.
NUCLEI BEYOND THE PROTON DRIP-LINE
Authors: Woods P. J. , Davids C. N.
Published: July 2002

▪ Abstract  The proton drip-line defines the limit at which nuclei become unbound to the emission of a proton from their ground states. Low-Z nuclei lying beyond this limit only exist as short-lived resonances and cannot be detected directly. The location of the drip-line constrains the path of nucleosynthesis in explosive astrophysical scenarios such as novae and X-ray bursters, and consequently controls the rate of energy generation. In higher-Z regions of the drip-line, the potential energy barrier resulting from the mutual electrostatic interaction between the unbound proton and the core can cause nuclei to survive long enough to be detected. This review describes the recent major advances in the study of these exotic nuclei. Particular emphasis is placed on understanding the phenomenon of proton radioactivity and the unique insights it offers into the structure of nuclei lying beyond one of nature's fundamental limits to stability.
CARNITINE METABOLISM AND ITS REGULATION IN MICROORGANISMS AND MAMMALS
Authors: Rebouche Charles J. , Seim Hermann
Published: July 2002

▪ Abstract  In procaryotes, l-carnitine may be used as both a carbon and nitrogen source for aerobic growth, or the carbon chain may be used selectively following cleavage of trimethylamine. Under anaerobic conditions and in the absence of preferred substrates, some bacteria use carnitine, via crotonobetaine, as an electron acceptor. Formation of trimethylamine and γ-butyrobetaine (from reduction of crotonobetaine) from l-carnitine by enteric bacteria has been demonstrated in rats and humans. Carnitine is not degraded by enzymes of eukaryotic origin. In higher organisms, carnitine has specific functions in intermediary metabolism. Concentrations of carnitine and its esters in cells of eukaryotes are rigorously maintained to provide optimal function. Carnitine homeostasis in mammals is preserved by a modest rate of endogenous synthesis, absorption from dietary sources, efficient reabsorption, and mechanisms present in most tissues that establish and maintain substantial concentration gradients between intracellular and extracellular carnitine pools.
REGULATION OF GLUCOSE PRODUCTION BY THE LIVER
Authors: Nordlie Robert C. , Foster James D. , Lange Alex J.
Published: July 2002

▪ Abstract  Glucose is an essential nutrient for the human body. It is the major energy source for many cells, which depend on the bloodstream for a steady supply. Blood glucose levels, therefore, are carefully maintained. The liver plays a central role in this process by balancing the uptake and storage of glucose via glycogenesis and the release of glucose via glycogenolysis and gluconeogenesis. The several substrate cycles in the major metabolic pathways of the liver play key roles in the regulation of glucose production. In this review, we focus on the short- and long-term regulation glucose-6-phosphatase and its substrate cycle counterpart, glucokinase. The substrate cycle enzyme glucose-6-phosphatase catalyzes the terminal step in both the gluconeogenic and glycogenolytic pathways and is opposed by the glycolytic enzyme glucokinase. In addition, we include the regulation of GLUT 2, which facilitates the final step in the transport of glucose out of the liver and into the bloodstream.
The Behavioral Determinants of Exercise: Implications for Physical Activity Interventions
Authors: Sherwood Nancy E. , Jeffery Robert W.
Published: July 2002

In light of the well-documented health benefits of physical activity and the fact that the majority of adult men and women are inactive, promoting regular physical activity is a public health priority. This chapter reviews current research findings regarding the determinants of exercise behavior. It also discusses the implications of this knowledge for individual and public health recommendations and intervention strategies for promoting physical activity. The discussion is predicated on the belief that physical activity is a complex, dynamic process. During their lives, individuals typically move through various phases of exercise participation that are determined by diverse factors. This chapter discusses physical activity determinants in two broad categories: individual characteristics, including motivations, self-efficacy, exercise history, skills, and other health behaviors; and environmental characteristics such as access, cost, and time barriers and social and cultural supports.
Molecular Psychology: Roles for the ERK MAP Kinase Cascade in Memory
Authors: Adams J. Paige , Sweatt J. David
Published: July 2002

In this review we describe an emerging understanding of the roles of the Extracellular-signal regulated kinase/mitogen-activated protein kinase (ERK/MAPK) cascade in learning and memory. We begin by describing several behavioral memory paradigms and review data implicating ERK as an essential component of the signal transduction mechanisms subserving these processes. We then describe evidence implicating ERK as a critical player in synaptic and neuronal plasticity—a cellular role likely to underlie ERK's behavioral role in the animal. We then proceed to parsing the complexities of biochemical regulation of ERK in neurons and to a description of a few likely cellular targets of ERK. This is in order to begin discussing the possible molecular basis of ERK-mediated behavioral change. We close our review with speculations concerning how the complexities and idiosyncrasies of ERK regulation may allow for sophisticated information processing at the biochemical level in neurons—attributes that may make the ERK cascade well-suited for triggering complex and long-lasting behavioral change. Our goal in this review is not so much to portray ERK as unique regarding its role as a signal transducter in memory, but rather to use ERK as one specific example of recent studies beginning to address the molecules and signal transduction pathways subserving cognition.
THE CELLULAR AND MOLECULAR RESPONSE OF CARDIAC MYOCYTES TO MECHANICAL STRESS
Authors: Sadoshima Junichi , Izumo Seigo
Published: July 2002

▪ Abstract  External load plays a critical role in determining muscle mass and its phenotype in cardiac myocytes. Cardiac myocytes have the ability to sense mechanical stretch and convert it into intracellular growth signals, which lead to hypertrophy. Mechanical stretch of cardiac myocytes in vitro causes activation of multiple second messenger systems that are very similar to growth factor-induced cell signaling systems. Stretch of neonatal rat cardiac myocytes stimulates a rapid secretion of angiotensin II which, together with other growth factors, mediates stretch-induced hypertrophic responses in vitro. In this review, various cell signaling mechanisms initiated by mechanical stress on cardiac myocytes are summarized with emphasis on potential mechanosensing mechanisms and the relationship between mechanical loading and the cardiac renin-angiotensin system.
THE MANY ROLES OF c-Myc IN APOPTOSIS
Authors: Thompson E. Brad
Published: July 2002

▪ Abstract  The proto-oncogene c-myc encodes a transcription factor c-Myc, which is of great importance in controlling cell growth and vitality. The quantity of c-Myc is carefully controlled by many mechanisms, and its actions to induce and repress genes are modulated by interactions with other regulatory proteins. Understanding the kinetic and quantitative relationships that determine how and what genes c-Myc regulates is essential to understanding how Myc is involved in apoptosis. Reduction of c-myc expression and its inappropriate expression can be associated with cellular apoptosis. This review outlines the nature and regulation of the c-myc gene and of c-Myc and presents the systems and conditions in which Myc-related apoptotic events occur. Hypotheses of the mechanisms by which expression and repression of c-myc lead to apoptosis are discussed.
Functional Consequences of Altering Myocardial Adrenergic Receptor Signaling
Authors: Koch W. J. , Lefkowitz R. J. , Rockman H. A.
Published: July 2002

▪ Abstract  From the ability to successfully manipulate the mouse genome has come important transgenic and gene-targeted knockout models that impact many areas of biomedical research. Genetically engineered mouse models geared toward the study of cardiovascular regulation have recently been described and provide powerful tools to study normal and compromised cardiac physiology. The genetic manipulation of the adrenergic receptor (AR) signaling system in the heart, including its regulation by desensitizing kinases, has shed light on the role of this signaling pathway in the regulation of cardiac contractility. One major finding, supported by several mouse models, is that in vivo contractility can be enhanced via alteration of myocardial AR signaling. Thus genetic manipulation of this critical receptor system in the heart represents a novel therapeutic approach for improving function of the failing heart.
Leptin
Authors: Ahima Rexford S. , Flier Jeffrey S.
Published: July 2002

▪ Abstract  The discovery of the adipose-derived hormone leptin has generated enormous interest in the interaction between peripheral signals and brain targets involved in the regulation of feeding and energy balance. Plasma leptin levels correlate with fat stores and respond to changes in energy balance. It was initially proposed that leptin serves a primary role as an anti-obesity hormone, but this role is commonly thwarted by leptin resistance. Leptin also serves as a mediator of the adaptation to fasting, and this role may be the primary function for which the molecule evolved. There is increasing evidence that leptin has systemic effects apart from those related to energy homeostasis, including regulation of neuroendocrine and immune function and a role in development.
The Mechanism of Action of Thyroid Hormones
Authors: Zhang Jinsong , Lazar Mitchell A.
Published: July 2002

▪ Abstract  Thyroid hormone is essential for normal development, differentiation, and metabolic balance. Thyroid hormone action is mediated by multiple thyroid hormone receptor isoforms derived from two distinct genes. The thyroid hormone receptors belong to a nuclear receptor superfamily that also includes receptors for other small lipophilic hormones. Thyroid hormone receptors function by binding to specific thyroid hormone-responsive sequences in promoters of target genes and by regulating transcription. Thyroid hormone receptors often form heterodimers with retinoid X receptors. Heterodimerization is regulated through distinct mechanisms that together determine the specificity and flexibility of the sequence recognition. Amino-terminal regions appear to modulate thyroid hormone receptor function in an isoform-dependent manner. Unliganded thyroid hormone receptor represses transcription through recruitment of a corepressor complex, which also includes Sin3A and histone deacetylase. Ligand binding alters the conformation of the thyroid hormone receptor in such a way as to release the corepressor complex and recruit a coactivator complex that includes multiple histone acetyltransferases, including a steroid receptor family coactivator, p300/CREB-binding protein–associated factor (PCAF), and CREB binding protein (CBP). The existence of histone-modifying activities in the transcriptional regulatory complexes indicates an important role of chromatin structure. Stoichiometric, structural, and sequence-specific rules for coregulator interaction are beginning to be understood, as are aspects of the tissue specificity of hormone action. Moreover, knockout studies suggest that the products of two thyroid hormone receptor genes mediate distinct functions in vivo. The increased understanding of the structure and function of thyroid hormone receptors and their interacting proteins has markedly clarified the molecular mechanisms of thyroid hormone action.
Genetic Assembly of the Heart: Implications for Congenital Heart Disease
Authors: Srivastava Deepak
Published: July 2002

▪ Abstract  More children die from congenital heart defects (CHD) each year than are diagnosed with childhood cancer, yet the causes remain unknown. The remarkable conservation of genetic pathways regulating cardiac development in species ranging from flies to humans provides an opportunity to experimentally dissect the role of critical cardiogenic factors. Utilization of model biological systems has resulted in a molecular framework in which to consider the etiology of CHD. As whole genome sequencing and single nucleotide polymorphism data become available, identification of genetic mutations predisposing to CHD may allow preventive measures by modulation of secondary genetic or environmental factors. In this review, genetic pathways regulating cardiogenesis revealed by cross-species studies are reviewed and correlated with human CHD.
MORPHOGENESIS AND MECHANISMS OF PENETRATION BY PLANT PATHOGENIC FUNGI
Authors: Mendgen K. , Hahn M. , Deising H.
Published: July 2002

▪ Abstract  Infection structures of phytopathogenic fungi are modified hyphae specialized for the invasion of plant tissues. Initial events are adhesion to the cuticle and directed growth of the germ tube on the plant surface. At the site of penetration, appressoria are often formed that may have melanized walls and develop high turgor pressure to support the penetration process. The penetration hypha accumulates components of the cytoskeleton in the tip and secretes a variety of cell wall–degrading enzymes in a highly regulated fashion in order to penetrate the cuticle and the plant cell wall. This article reviews recent papers on the cytology, physiology, and molecular biology of the penetration process.
SYSTEMIC ACQUIRED RESISTANCE
Authors: Sticher L , Mauch-Mani B , Métraux and JP
Published: July 2002

▪ Abstract  This paper examines induced resistance (SAR) in plants against various insect and pathogenic invaders. SAR confers quantitative protection against a broad spectrum of microorganisms in a manner comparable to immunization in mammals, although the underlying mechanisms differ. Discussed here are the molecular events underlying SAR: the mechanisms involved in SAR, including lignification and other structural barriers, pathogenesis-related proteins and their expression, and the signals for SAR including salicylic acid. Recent findings on the biological role of systemin, ethylene, jasmonates, and electrical signals are reviewed. Chemical activators of SAR comprise inorganic compounds, natural compounds, and synthetic compounds. Plants known to exhibit SAR and induced systemic resistance are listed.
Emotions in Politics
Authors: Marcus G. E.
Published: July 2002

The study of emotion in politics has been active, especially as it relates to the personality of political leaders and as an explanation for how people evaluate significant features around them. Researchers have been divided into two groups—those who study leaders and those who study publics. The research programs have also been divided between those who use emotion to explain reliance on early experience that dominates contemporary judgment and those who use emotion to explain why people respond to the immediate contemporary circumstances around them. More recently, theory and research have attempted to reconcile these two seemingly contradictory roles by integrating them. Emotion's role in politics is pervasive both because emotion enables past experience to be encoded with its evaluative history and because emotion enables contemporary circumstances to be quickly evaluated. More recently still, theoretical models and supporting evidence suggest that there are multiple channels of emotional evaluations.
STEREOTYPES
Authors: Hilton James L. , von Hippel William
Published: July 2002

▪ Abstract  The stereotyping literature within psychology has grown considerably over the past decade. In large part, this growth can be attributed to progress in understanding the individual mechanisms that give rise to stereotypic thinking. In the current review, the recent psychological literature on stereotypes is reviewed, with particular emphasis given to the cognitive and motivational factors that contribute to stereotype formation, maintenance, application, and change. In addition, the context-dependent function of stereotypes is highlighted, as are the representational issues that various models of stereotypes imply.
TEAMS IN ORGANIZATIONS: Recent Research on Performance and Effectiveness
Authors: Guzzo Richard A. , Dickson Marcus W.
Published: July 2002

▪ Abstract  This review examines recent research on groups and teams, giving special emphasis to research investigating factors that influence the effectiveness of teams at work in organizations. Several performance-relevant factors are considered, including group composition, cohesiveness, and motivation, although certain topics (e.g. composition) have been more actively researched than others in recent years and so are addressed in greater depth. Also actively researched are certain types of teams, including flight crews, computer-supported groups, and various forms of autonomous work groups. Evidence on basic processes in and the performance effectiveness of such groups is reviewed. Also reviewed are findings from studies of organizational redesign involving the implementation of teams. Findings from these studies provide some of the strongest support for the value of teams to organizational effectiveness. The review concludes by briefly considering selected open questions and emerging directions in group research.
THE MOTIVATIONAL IMPACT OF TEMPORAL FOCUS: Thinking About the Future and the Past
Authors: Karniol Rachel , Ross Michael
Published: July 2002

▪ Abstract  In this chapter, we consider the degree to which individuals are pulled to behave by their conceptions of the future, pushed to act by their recollections of the past, or primarily driven by current exigencies. In examining conceptions of the future, we discuss how individuals bridge the present and the future, the origin of goals, their impact on behavior and cognition, and the motivational underpinnings for inferring other people's goals. We then outline four theoretical approaches to goal prioritization, the motivational impact of proximal vs distal goals, and the distinction between approaching positive vs avoiding negative outcomes. Turning to conceptions of the past, we discuss the motivational push of the past, the use of the past to select one's goals, the impact current goals have on recall and interpretations of the past, and individual differences in using the past. We conclude that temporal focus provides a meaningful framework for social cognitive approaches to motivation.
COGNITIVE NEUROSCIENCE OF HUMAN MEMORY
Authors: Gabrieli J. D. E.
Published: July 2002

▪ Abstract  Current knowledge is summarized about long-term memory systems of the human brain, with memory systems defined as specific neural networks that support specific mnemonic processes. The summary integrates convergent evidence from neuropsychological studies of patients with brain lesions and from functional neuroimaging studies using positron emission tomography (PET) or functional magnetic resonance imaging (fMRI). Evidence is reviewed about the specific roles of hippocampal and parahippocampal regions, the amygdala, the basal ganglia, and various neocortical areas in declarative memory. Evidence is also reviewed about which brain regions mediate specific kinds of procedural memory, including sensorimotor, perceptual, and cognitive skill learning; perceptual and conceptual repetition priming; and several forms of conditioning. Findings are discussed in terms of the functional neural architecture of normal memory, age-related changes in memory performance, and neurological conditions that affect memory as such amnesia, Alzheimer's disease, Parkinson's disease, and Huntington's disease.
Parental and Child Cognitions in the Context of the Family
Authors: Bugental Daphne Blunt , Johnston Charlotte
Published: July 2002

Parent and child family-related cognitions are reviewed with respect to (a) their origins, (b) their linkage to affect and behavior, (c) their transmission and perpetuation, (d) their alteration on the basis of first-hand experience, and (e) their collaborative negotiation and renegotiation. A distinction is offered between the functioning of implicit, relatively unaware, schematic cognitions and relatively aware, explicit, event-dependent cognitions. Consideration is also given to the differential content (or topics) of cognitions. As a positive outcome of recent research, many new insights have emerged with respect to the linkage of family members’ cognitions and their individual and shared patterns of behavior. However, several limitations remain, including too little consideration of the shared influences of parents’ and children’s cognitions and the changes in these cognitions over time. As a growth area, there is emerging interest in the application of our knowledge of cognitions to the clinical context in programs designed to remediate and prevent family problems.
U-Shaped Dose-Responses in Biology, Toxicology, and Public Health
Authors: Calabrese Edward J , Baldwin Linda A
Published: July 2002

▪ Abstract  The occurrence of U-shaped dose-response relationships (often termed hormesis) has been documented in numerous biological, toxicological, and pharmacological investigations. Many of the endpoints studied are of considerable significance to public health (e.g. body weight, cholesterol levels, ethanol consumption, longevity, cancer incidence, etc). Despite the fact that U-shaped dose-responses are widely and independently observed, little attempt has been made to assess this phenomenon in an integrative manner. This review provides an overview of the historical foundations of hormesis and a discussion of its definition within a mechanistic framework. The occurrence, generalizability, and biological significance of U-shaped dose-response relationships along with the concept of biological optimality are addressed.
The Public Health Impact of Alzheimer's Disease, 2000–2050: Potential Implication of Treatment Advances
Authors: Sloane Philip D. , Zimmerman Sheryl , Suchindran Chirayath , Reed Peter , Wang Lily , Boustani Malaz , Sudha S.
Published: July 2002

▪ Abstract  Recent developments in basic research suggest that therapeutic breakthroughs may occur in Alzheimer's disease treatment over the coming decades. To model the potential magnitude and nature of the effect of these advances, historical data from congestive heart failure and Parkinson's disease were used. Projections indicate that therapies which delay disease onset will markedly reduce overall disease prevalence, whereas therapies to treat existing disease will alter the proportion of cases that are mild as opposed to moderate/severe. The public health impact of such changes would likely involve both the amount and type of health services needed. Particularly likely to arise are new forms of outpatient services, such as disease-specific clinics and centers. None of our models predicts less than a threefold rise in the total number of persons with Alzheimer's disease between 2000 and 2050. Therefore, Alzheimer's care is likely to remain a major public health problem during the coming decades.
Socioeconomic Status and Health: The Potential Role of Environmental Risk Exposure
Authors: Evans Gary W. , Kantrowitz Elyse
Published: July 2002

▪ Abstract  Among several viable explanations for the ubiquitous SES-health gradient is differential exposure to environmental risk. We document evidence of inverse relations between income and other indices of SES with environmental risk factors including hazardous wastes and other toxins, ambient and indoor air pollutants, water quality, ambient noise, residential crowding, housing quality, educational facilities, work environments, and neighborhood conditions. We then briefly overview evidence that such exposures are inimical to health and well-being. We conclude with a discussion of the research and policy implications of environmental justice, arguing that a particularly salient feature of poverty for health consequences is exposure to multiple environmental risk factors.
Warmer and More Social: Recent Developments in Cognitive Social Psychology
Authors: Schwarz Norbert
Published: July 2002

Since the late 1970s, theorizing in psychological social psychology has been dominated by the computer metaphor of information processing models, which fostered an emphasis on “cold” cognition and the conceptualization of individuals as isolated information processors. More recent research shows a renewed interest in the interplay of feeling and thinking in social judgment and in the role of unconscious processes in reasoning and behavior. Moreover, research into socially situated cognition and the interplay of communication and cognition highlights the role of conversational norms, social interdependence, and power in social judgment. Experimental research into these issues is reviewed. The emerging picture is compatible with social psychology's latest metaphor, humans as motivated tacticians who pragmatically adapt their reasoning strategies to the requirements at hand.
OWNERSHIP ORGANIZATION AND FIRM PERFORMANCE
Authors: Kang David L. , Sørensen Aage B.
Published: July 2002

▪ Abstract  This essay reviews research on the type and degree of fragmentation of firm ownership with an emphasis on the consequences of ownership organization for firm performance. We use a property rights approach to synthesize sociological, organizational, legal, and economic research that has examined the effect of ownership organization on firm performance. Agency theorists generally assume that shareholders are homogenous and that their influence on firm performance is directly proportional to the percentage of equity they hold. However, empirical research following this approach has failed to produce definitive evidence. Class analysis perspectives interpret these inconclusive results as demonstrating that, regardless of ownership organization, firms are run to serve the capitalist class. An alternative interpretation is that shareholders are not homogeneous but that certain types of shareholders use their formal authority, social influence, and expertise to “capture” property rights and strongly influence firm performance. The influence of different types of owners may depend on industry characteristics, and we review literature pointing to a contingency theory of ownership organization.
Framing Processes and Social Movements: An Overview and Assessment
Authors: Benford Robert D. , Snow David A.
Published: July 2002

The recent proliferation of scholarship on collective action frames and framing processes in relation to social movements indicates that framing processes have come to be regarded, alongside resource mobilization and political opportunity processes, as a central dynamic in understanding the character and course of social movements. This review examines the analytic utility of the framing literature for understanding social movement dynamics. We first review how collective action frames have been conceptualized, including their characteristic and variable features. We then examine the literature related to framing dynamics and processes. Next we review the literature regarding various contextual factors that constrain and facilitate framing processes. We conclude with an elaboration of the consequences of framing processes for other movement processes and outcomes. We seek throughout to provide clarification of the linkages between framing concepts/processes and other conceptual and theoretical formulations relevant to social movements, such as schemas and ideology.
Fetal Uninephrectomy Leads to Postnatal Hypertension and Compromised Renal Function
Authors: Moritz Karen M. , Wintour E. Marelyn , Dodic Miodrag
Published: July 2002

It has been proposed that the number of nephrons an individual has may be inversely related to his or her blood pressure. In this study using female ovine fetuses, nephron number was reduced by performing a fetal uninephrectomy during the period of active nephrogenesis (100 days of gestation, term=150 days). Lambs were born at term and grew at a similar rate. At 5 months of age, ovaries were removed and the carotid artery exteriorized into a fold of skin. Blood pressure and renal function were studied at 6 and 12 months of age. At 6 months of age, uninephrectomized lambs had significantly higher mean arterial blood pressure than sham-operated lambs (89±2 versus 82±2 mm Hg,
P
<0.05) when measured over a 3-day period. Heart rate was not different between the groups. Urine flow rate was similar, but glomerular filtration rate was significantly lower in uninephrectomized animals (
P
<0.05). Urinary concentrations and excretion rates of sodium tended to be higher in uninephrectomized animals but were similar for chloride and potassium. There was no evidence of proteinuria in the uninephrectomized lambs. Similar differences were observed in blood pressure and renal function at 12 months of age. Plasma renin concentrations at this age were lower in the uninephrectomized lambs (
P
<0.05). An oral salt load for 10 days did not increase blood pressure significantly in either group at 12 months of age, nor were there differences in the responsiveness to graded doses of angiotensin II. These results suggest that formation of a low nephron number in utero, may result in elevated blood pressure and compromised renal function in later life.
Conclusion: The Causes and Consequences of Legalization
Authors: Kahler Miles
Published: July 2002

The intersection of law and politics provides tentative answers for two questions: First, why, among the variety of institutional forms available to governments, are legalized institutions preferred in some contexts and not in others? Second, what are the consequences of legalization? Explanations for variation in legalization are directed to the supply of legalized institutions, grounded in the preferences of the most powerful states. Those preferences are shaped, in turn, by domestic political demands for legalization as well as unanticipated domestic political dynamics that can increase legalization over time. Domestic political demands for legalization have increased as a result of international economic integration; the effects of democratization have been more ambiguous. Outside the industrialized democracies, the intersection of supply and demand is often different: supply of legalized institutions is lower and sovereignty costs are often higher. The authors in this special issue examine three important consequences of legalization: its effects on government compliance with international agreements, its impact on the evolution of international norms, and the conditions under which it will harden and spread. In each case, domestic political links are central to the effects of legalization. International agreements and institutions that are legalized, compared with those that are not, seem to be more deeply rooted in domestic politics: their existence often draws on both anticipated and unanticipated actions by domestic actors; their consequences are shaped by domestic characteristics and constituencies.
Realism in the Study of World Politics
Authors: Jervis Robert
Published: July 2002

The popularity of alternative approaches to international politics cannot be explained entirely by their scholarly virtues. Among the other factors at work are fashions and normative and political preferences. This in part explains the increasing role of rationalism and constructivism. Important as they are, these approaches are necessarily less complete than liberalism, Marxism, and realism. Indeed, they fit better with the latter than is often realized. Realism, then, continues to play a major role in IR scholarship. It can elucidate the conditions and strategies that are conducive to cooperation and can account for significant international change, including a greatly decreased tolerance for force among developed countries, which appears to be currently the case. But neither it nor other approaches have as yet proved to be reliable guides to this new world.
Case Studies and the Statistical Worldview: Review of King, Keohane, and Verba's Designing Social Inquiry: Scientific Inference in Qualitative Research
Authors: McKeown Timothy J.
Published: July 2002

Gary King, Robert O. Keohane, and Sydney Verba's Designing Social Inquiry exploits the metaphor of researcher-as-statistician to develop guidelines for conducting social scientific research that are allegedly applicable to all empirical investigations. Their approach has sharp and often unflattering implications for case studies and similar research strategies. Because their statistical worldview is unable to make sense of important aspects of case study research or of the importance that is sometimes attached to the findings of a single case, their argument seemingly casts doubt on the wisdom of producing or consuming such studies.

I argue that the foundation of classical statistics and the epistemology of Carl Hempel and Karl Popper is an inadequate and misleading basis for a critical evaluation of case studies. I then present examples of research that are not easily accommodated within the authors' framework and sketch the elements of an alternative epistemological framework rooted in a “pattern” model of explanation. The latter is a standpoint that is much more helpful in understanding and criticizing case studies than the framework presented in Designing Social Inquiry.
The Politics, Power, and Pathologies of International Organizations
Authors: Barnett Michael N. , Finnemore Martha
Published: July 2002

International Relations scholars have vigorous theories to explain why international organizations (IOs) are created, but they have paid little attention to IO behavior and whether IOs actually do what their creators intend. This blind spot flows logically from the economic theories of organization that have dominated the study of international institutions and regimes. To recover the agency and autonomy of IOs, we offer a constructivist approach. Building on Max Weber's well-known analysis of bureaucracy, we argue that IOs are much more powerful than even neoliberals have argued, and that the same characteristics of bureaucracy that make IOs powerful can also make them prone to dysfunctional behavior. IOs are powerful because, like all bureaucracies, they make rules, and, in so doing, they create social knowledge. IOs deploy this knowledge in ways that define shared international tasks, create new categories of actors, form new interests for actors, and transfer new models of political organization around the world. However, the same normative valuation on impersonal rules that defines bureaucracies and makes them powerful in modern life can also make them unresponsive to their environments, obsessed with their own rules at the expense of primary missions, and ultimately produce inefficient and self-defeating behavior. Sociological and constructivist approaches thus allow us to expand the research agenda beyond IO creation and to ask important questions about the consequences of global bureaucratization and the effects of IOs in world politics.
Using Capture-Recapture Methods to Reconstruct the American Population in London
Authors: Flavell Julie M. , Hay Gordon
Published: July 2002

The capture-recapture method, which ecologists, demographers, and social scientists utilize to estimate the size of contemporary populations that cannot be subjected to conventional enumeration or census-taking procedures, has never been applied to the study of a historical population. Using it to uncover the size and characteristics of the colonial American community in London finds regional variations in the demographic patterns of provincial Americans who traveled to London during the late colonial period, challenging the presumption of a common colonial reaction to metropolitan culture on the eve of American independence.
The Science Fiction of Technoscience: The Politics of Simulation and a Challenge for New Media Art
Authors: Thacker Eugene
Published: July 2002

This article sketches some of the relationships between the technosciences (primarily biotechnology and biomedicine) and science fiction. Taken as a discursive practice, science fiction constructs futurological narratives of progress as well as conditions the very techniques and research that may have taken place. The tensions and inconsistencies within the biotech industry are considered as a zone where science fiction is put to work as negotiator and mode of legitimization. However, as cultural theorists such as Fredric Jameson and Jean Baudrillard suggest, science fiction can also fulfill a critical function, highlighting the contingencies and limitations in biotech's self-fulfilling narrative of future-medicine. A consideration of the emerging category of “net.art” provides one starting point for a critical science fiction practice.
Have/Be Raising, Move F, and Procrastinate
Authors: Roberts Ian
Published: July 2002

This article proposes a simple modification to Chomsky's (1995:chap. 4) account of Move F(eature): that this operation is able to occur before Spell-Out. This idea has numerous potential consequences. Two theoretical consequences are explored here: that Move F corresponds to weak features and Move Category to strong features, and that Procrastinate is not required. The empirical motivation for overt Move F comes from Englishhave/be raising; it is argued that the auxiliaries are simple feature bundles moved as free riders with the overtly moved (weak) V-feature.
An Event-related Neuroimaging Study Distinguishing Form and Content in Sentence Processing
Authors: Ni W. , Constable R. T. , Mencl W. E. , Pugh K. R. , Fulbright R. K. , Shaywitz S. E. , Shaywitz B. A. , Gore J. C. , Shankweiler D.
Published: July 2002

Two coordinated experiments using functional Magnetic Resonance Imaging (fMRI) investigated whether the brain represents language form (grammatical structure) separately from its meaning content (semantics). While in the scanner, 14 young, unimpaired adults listened to simple sentences that were either nonanomalous or contained a grammatical error (for example, *Trees can grew.), or a semantic anomaly (for example, *Trees can eat.). A same/different tone pitch judgment task provided a baseline that isolated brain activity associated with linguistic processing from background activity generated by attention to the task and analysis of the auditory input. Sites selectively activated by sentence processing were found in both hemispheres in inferior frontal, middle, and superior frontal, superior temporal, and temporo-parietal regions. Effects of syntactic and semantic anomalies were differentiated by some nonoverlapping areas of activation: Syntactic anomaly triggered significantly increased activity in and around Broca's area, whereas semantic anomaly activated several other sites anteriorly and posteriorly, among them Wernicke's area. These dissociations occurred when listeners were not required to attend to the anomaly. The results confirm that linguistic operations in sentence processing can be isolated from nonlinguistic operations and support the hypothesis of a specialization for syntactic processing.
Abnormal Processing of Social Information from Faces in Autism
Authors: Adolphs Ralph , Sears Lonnie , Piven Joseph
Published: July 2002

Autism has been thought to be characterized, in part, by dysfunction in emotional and social cognition, but the pathology of the underlying processes and their neural substrates remain poorly understood. Several studies have hypothesized that abnormal amygdala function may account for some of the impairments seen in autism, specifically, impaired recognition of socially relevant information from faces. We explored this issue in eight high-functioning subjects with autism in four experiments that assessed recognition of emotional and social information, primarily from faces. All tasks used were identical to those previously used in studies of subjects with bilateral amygdala damage, permitting direct comparisons. All subjects with autism made abnormal social judgments regarding the trustworthiness of faces; however, all were able to make normal social judgments from lexical stimuli, and all had a normal ability to perceptually discriminate the stimuli. Overall, these data from subjects with autism show some parallels to those from neurological subjects with focal amygdala damage. We suggest that amygdala dysfunction in autism might contribute to an impaired ability to link visual perception of socially relevant stimuli with retrieval of social knowledge and with elicitation of social behavior.