bluuebunny/crossref_metadata_2025 huggingface dataset:
Viability Modeling for Decision Support with Limited Data: A Lizard Case Study
Authors: Goode Ashley B.C. , Allan Nathan , McGowan Conor P.
Published: June 2024

The Plateau Spot-Tailed Earless Lizard Holbrookia lacerata is a species of ground lizard in central Texas, USA, that is under review for listing as endangered under the U.S. Endangered Species Act. Despite this status, there is a lack of development of predictive models of population dynamics or viability. Herein, we used the limited available data and published demographic rates in a population viability analysis model to predict the future status of this lizard species under parametric and ecological uncertainty and temporal variability. Even in cases where data are sparse and life history information is limited, viability models can help clarify the consequences of management choices given the uncertainty. Our model predicted that, on average, populations of H. lacerata will decline in the future. Quasi-extinction probability was low 20 y into the future, but up to 0.60 by 50 y. Extinction risk was highly dependent on the road mortality effect and the proportion of the population exposed to roadways, both of which are currently uncertain quantities. Despite these unknowns, our model enables managers to consider the future abundance and extinction risk for H. lacerata and make decisions about management to project population viability and it also identifies key uncertainties for future research and monitoring.
Spatial Variation in Flowering Age in Cirsium pitcheri: Does This Imperiled Dune Thistle Hedge Its Bets?
Authors: Priemer Lucas A. , Girdler E. Binney
Published: June 2024

For perennial plants, the optimal timing of flowering is a tradeoff between survivorship and fecundity, a classic example of bet-hedging. For many monocarpic perennials, there is an advantage in delaying flowering until the plant reaches a larger size and is thus capable of a higher fecundity. However, in delaying flowering, there is a risk that the plant will die before ever reproducing. Here, we investigate this fitness trade-off in the imperiled dune thistle, Cirsium pitcheri (Torr. ex Eaton) Torr. & A. Gray (Asteraceae) (Pitcher’s thistle). Using a long-term, spatially explicit demographic data set with yearly censuses, we found that C. pitcheri individuals on the foredune flowered at a younger age compared to individuals in other dune habitats. We tested two alternative hypotheses: (1) younger flowering plants were able to reach a flowering threshold size more quickly, and (2) these plants were somehow stressed, and slow growth was a signal for high likelihood of dying, resulting in early reproduction at a smaller size. Our results support the former hypothesis: plants in all areas of the dune did not differ in size the year prior to flowering, despite spatial differences in age of flowering individuals. Therefore we conclude that the foredune microenvironment where plants flowered at younger ages facilitates rapid growth and reproduction for this species and may represent optimal habitat. This result provides insight into the demographic patterns of C. pitcheri that may inform the conservation and recovery of this threatened species. Although adapted to the dynamic dune environments of the Great Lakes, C. pitcheri may be vulnerable to climate change-induced changes in its optimal foredune habitat.
L’anastasis de Jean-Luc Nancy
Authors: Husson Valentin
Published: June 2024

On essaye dans cet article de lire l’œuvre de Jean-Luc Nancy à partir du motif de l’anastasis. À chaque fois quelque chose se relève d’entre les morts : le sens se relève de la signification, le monde de l’immonde de la mondialisation, le christianisme de la fin du religieux, le corps de sa dévaluation occidentale au profit de l’esprit, la communauté de l’échec du communisme étatisé et de l’individualisme forcené. Ne serait-ce pas simplement la vie, qui de manière unique, dans tous ces phénomènes, se relève de la mort, et se maintient vivant en elle ?
La tonalité du sens
Authors: Potestà Andrea
Published: June 2024

L’article propose une relecture de la question du corps et du sens chez Jean-Luc Nancy à partir du phénomène sonore. L’enjeu de la tonalité, de la voix et de l’écoute ont été au centre de plusieurs études de Nancy tout au long de sa production philosophique, mais c’est à partir de sa dernière publication, le livre Cruor, que l’analyse de la propagation sonore vers le dehors acquiert une importance majeure dans la pensée des corps. Le son implique une fragmentation qui suspend toute rhétorique du contact et toute valorisation spatiale de « l’entre » (de l’entre-deux, de l’entre-nous, de l’être-avec).
Du « sens du sens » qu’il n’y a pas
Authors: Rigal Élisabeth
Published: June 2024

L’objectif de mon étude est de mettre en évidence les enjeux de l’affirmation de Jean-Luc Nancy selon laquelle « il n’y a pas de ‘‘Sens (dernier) du sens’’ en aucun des sens de “sens” ». À cette fin, je prends en considération sa reconnaissance du tarissement complet du régime de sens qui a porté l’histoire de l’Occident, et je montre comment sa déconstruction déleste « le sens du monde » de toute origine, de tout principe, et de toute fin, pour penser l’incomplétude foncière d’un sens qui abrite le déploiement singulier-pluriel de l’existence et dont il n’y a pas d’appropriation possible, car il s’envoie, se renvoie et circule sans jamais se déposer.
Thérèse d’Avila (1515-1582)
Authors: Sesé Bernard
Published: June 2024

Dans cet article, initialement publié en 2016 dans l’ouvrage collectif La Bible dans les littératures du monde, Bernard Sesé présente la vie et l’œuvre de Thérèse d’Avila, au prisme de sa relation avec l’Ancien et le Nouveau Testament.
Poétique de la mort selon Thérèse d’Avila et Jean de la Croix
Authors: Sesé Bernard
Published: June 2024

Dans cet article, initialement publié en 2008 dans l’ouvrage collectif Figures de la mort dans la littérature de langue espagnole, Bernard Sesé analyse le motif de la mort dans les œuvres de Thérèse d’Avila et de Jean de la Croix. Il étudie le champ sémantique et lexical de la mort et en explore les différentes figures, du deuil à la fascination, de l’agonie à l’état béatifique.
Jean de la Croix ou la passion de Dieu
Authors: Sesé Bernard
Published: June 2024

Dans cet article, initialement publié en 1993 dans l’ouvrage collectif Poésie espagnole en cette fin de siècle. Les fleuves les plus longs, Bernard Sesé propose une introduction à la vie et à l’œuvre poétique de Jean de la Croix, en insistant notamment sur sa réception par les poètes au XXe siècle.
Jean de la Croix et l’invention du « féminin »
Authors: Sesé Bernard
Published: June 2024

Dans cet article, initialement publié en 2002 dans l’ouvrage collectif Invention du féminin, Bernard Sesé la vie, l’expérience mystique et l’œuvre poétique de Jean de la Croix au prisme d’un concept : le « féminin ».
Essai d’interprétation d’un poème de Jean de la Croix : Entreme donde no supe
Authors: Sesé Bernard
Published: June 2024

Dans cet article, initialement publié en 1990 dans un ouvrage collectif en hommage à Jaime Díaz-Rozzotto, Bernard Sesé étudie le poème Entreme donde no supe de Jean de la Croix. Il en fournit une analyse approfondie, s’attachant au contexte de composition, à l’argument, à la versification, mais aussi au traitement des concepts mystiques qui y apparaissent.
La déviance sociale à Londres vue par une enquêtrice socialiste française : Flora Tristan et les Promenades dans Londres (1840)
Authors: Michaud Stéphane
Published: June 2024

As early as the Restoration and even more still during the July Monarchy, many French social investigators chose to study England. They came from all social backgrounds and political parties and analysed the most industrialised country in Europe as the laboratory of the future. They focused on social contrasts and on the miserable living and working conditions of the proletariat. One may therefore wonder where Flora Tristan’s originality lay when she undertook to write about these deviancies. This question is all the more interesting as she was a self-taught writer, her childhood as an orphan having provided her with but a rudimentary education. Do her lack of culture and the difficulty she felt in dealing with her topic objectively impair the quality of the opinions she expressed in her book ? The huge success of London Walks among Socialist groups and the working classes proves the opposite and stresses the novelty of her analyses. Her female condition did not restrict the scope of her understanding of what she examined and her sense of being herself an outcast enabled her to provide an insider’s view of the conditions of the people she came in contact with.
‘The Dung-heap and the Flower’: Gissing’s Nether World
Authors: Messenger Nigel
Published: June 2024

This paper examines the creative dynamic behind Gissing’s most successful slum novel, The Nether World, by speculating on Gissing’s own ‘nether world’: in particular, his social disgrace following his conviction for petty theft at Owens College, Manchester and his sexual preference for uneducated, working class girls. Using the concept of ‘abjection’ as theorised by Julia Kristeva in Powers of Horror, the paper goes on to discuss some of the language, social settings and characters of The Nether World, and concludes by suggesting that Gissing’s novel anticipates some aspects of twentieth-century Modernism.
Democracy in education seen through the lens of dictatorship
Authors: Partouche Beatrice
Published: June 2024

In the 1930s, the well-known Norwegian-Italian filmmaker Ivo Caprino attended the Stabekk Gymnasium, at which Olav Storstein was among his teachers. Before his student became internationally famous, Olav Storstein described in his book Fremtiden sitter på skolebenken an episode in which they were both protagonists. The socialist teacher and the young student of Italian origin provide an opportunity to show two opposing educational models: democratic education and fascist authoritarianism. Through a process of inductive analysis that starts from the cited text and crosses archives and reference literature, this essay will highlight the contrast between these two models using for illustrative purposes the biographical episode that allows us to make a historical educational analysis in a comparative perspective, but also to place the episode in a broader context and relate it to relevant aspects of the period.  In this story, the interests of fascist propaganda abroad and in Italy, the fascist and socialist educational models, the activities of the Dante Alighieri society, and the private and professional lives of the two protagonists are intertwined.
Palliative Care in the Intensive Care Unit: The Standard of Care
Authors: Wiencek Clareen
Published: June 2024

Intensive care unit–based palliative care has evolved over the past 30 years due to the efforts of clinicians, researchers, and advocates for patient-centered care. Although all critically ill patients inherently have palliative care needs, the path was not linear but rather filled with the challenges of blending the intensive care unit goals of aggressive treatment and cure with the palliative care goals of symptom management and quality of life. Today, palliative care is considered an essential component of high-quality critical care and a core competency of all critical care nurses, advanced practice nurses, and other intensive care unit clinicians. This article provides an overview of the current state of intensive care unit–based palliative care, examines how the barriers to such care have shifted, reviews primary and specialist palliative care, addresses the impact of COVID-19, and presents resources to help nurses and intensive care unit teams achieve optimal outcomes.
Exploring Ecological Functions of Rice-Fish Integration in the Agricultural Landscape: A Review to Investigate Feasibility of Implementing Rice-Fish Integration in Sri Lanka
Authors: Kumara H. K. R. S. , Atapaththu K. S. S. , Herath S. S. , Vidanapathirana N. P. , Marasinghe M. M. K. I.
Published: June 2024

Rice-fish integration is, a symbiotic farming system where fish are reared in rice fields. Although this farming method widespread in many Asian countries, it is relatively new to Sri Lanka, and consequently information on its ecological functions under Sri Lankan context is scarce. Therefore, detailed investigation on the ecological function of rice fish integration would provide necessary information to establish rice-fish integration in Sri Lanka. This study followed a qualitative case study approach, including literature review and extensive document analysis. The results highlighted the rice-fish integration approach presents an array of ecological functions, underscoring its potential as a sustainable agricultural practice. Ecologically, the presence of fish in the system contributes to increase nutrient availability for rice plants, and biologically control weed and pest. Further, rice-fish integration promotes soil fertility of rice fields which improves growth and nutrient uptake of rice plants. The rice plants, in turn, play a pivotal role to maintain biodiversity in rice fields through water purification, establishing optimal water temperature conditions, and providing an array of micro habitats for a diverse aquatic fauna and flora. On the other hand, rice fish integration promotes water use efficiency, higher economic return and animal protein requirement of local farming communities. Considering ecological, economical and health benefits, integration of tilapia fish with suitable rice varieties available in Sri Lanka is proposed. In conclusion, the rice-fish integration is an ecologically balanced farming system which has a potential to enhance the sustainability of rice field farming systems in Sri Lanka.
NAVIGATING ARCTIC REALITIES: GEOPOLITICS, SECURITY, AND CLIMATE CHANGE
Authors: Cotta Filippo Alberto
Published: June 2024

Il presente lavoro si propone di offrire una visione completa delle principali questioni legate ai cambiamenti geopolitici nella regione Artica, insieme ad una panoramica della letteratura scientifica riguardante tali problematiche. Dopo un’analisi storica, la ricerca si focalizza sull’evoluzione della sicurezza artica, esaminando la presunta militarizzazione e l’impatto del cambiamento climatico. Successivamente, si esplorano le principali potenze coinvolte ed i loro interessi e strategie nella regione. Infine, ci si concentra sulle imprese economiche e sul multilateralismo nella zona, entrambi influenzati da eventi recenti e cambiamenti climatici.
THE EUROPEAN UNION AND THE CHALLENGES AHEAD: PROSPECTS AND TRENDS
Authors: Mattiolo Luigi
Published: June 2024

Not available.
UN System. Temi e problemi di storia internazionale
Authors: Mugnaini Marco
Published: June 2024

Non disponibile.
Milton Friedman: the Last Conservative
Authors: Burns Jennifer
Published: June 2024

Non disponibile
Hybrid electronic record: An error reduction strategy for diverse medical prescription formats
Authors: Kruse Carl-Heinz , Smith Michelle T.D. , Clarke Damian L.
Published: June 2024

Background: This project is part of a broader effort to develop a new electronic registry for ophthalmology in the KwaZulu-Natal (KZN) province in South Africa. The registry should include a clinical decision support system that reduces the potential for human error and should be applicable for our diversity of hospitals, whether electronic health record (EHR) or paper-based.Methods: Post-operative prescriptions of consecutive cataract surgery discharges were included for 2019 and 2020. Comparisons were facilitated by the four chosen state hospitals in KZN each having a different system for prescribing medications: Electronic, tick sheet, ink stamp and handwritten health records. Error types were compared to hospital systems to identify easily-correctable errors. Potential error remedies were sought by a four-step process.Results: There were 1307 individual errors in 1661 prescriptions, categorised into 20 error types. Increasing levels of technology did not decrease error rates but did decrease the variety of error types. High technology scripts had the most errors but when easily correctable errors were removed, EHRs had the lowest error rates and handwritten the highest.Conclusion: Increasing technology, by itself, does not seem to reduce prescription error. Technology does, however, seem to decrease the variability of potential error types, which make many of the errors simpler to correct.Contribution: Regular audits are an effective tool to greatly reduce prescription errors, and the higher the technology level, the more effective these audit interventions become. This advantage can be transferred to paper-based notes by utilising a hybrid electronic registry to print the formal medical record.
Oral Health Impact Profile in Patients with and without Type 2 Diabetes in Al-Baha Region, Saudi Arabia
Authors: Alzahrani Abdullah Ali H.
Published: June 2024

Introduction:

The Oral Health Impact Profile (OHIP) serves as a crucial tool in understanding the intricate relationship between oral health and systemic conditions like type 2 Diabetes. This study delves into the comparative analysis of OHIP in patients with and without type 2 diabetes, shedding light on the nuanced impact of this metabolic disorder on oral health-related quality of life (OHrQoL). By scrutinising factors such as oral discomfort, functional limitations and psychological well-being, this research aims to unearth valuable insights into the unique challenges faced by diabetic individuals in maintaining optimal oral health. Such findings hold immense significance in guiding tailored interventions and enhancing holistic healthcare approaches.

Materials and Methods:

A cross-sectional study was carried out with 232 diabetic and non-diabetic individuals. Clinical examinations were conducted, and a validated Arabic version of the OHIP-14 instrument was used. Data were analysed using the Statistical Package for the Social Sciences version 20.0.

Results:

In total, 232 patients with and without diabetes were included in this study. A statistically significant effect was observed amongst diabetic compared to non-diabetic participants (P = 0.015). The overall OHrQoL across the seven domains of participants with diabetes was significantly lower than those without diabetes (P = 0.0001). Oral lesions were more common and showed statistically significant effects amongst diabetic compared to non-diabetic patients (P = 0.0001).

Conclusion:

Patients with type 2 diabetes have shown undesirable oral health which impacted their quality of life compared to those without diabetes. Future research focusing on developing preventive interventional strategies for diabetic patients, in addition to enhancing the awareness of oral diseases and dental care amongst those patients, is highly encouraged. Developing a standardised protocol with a unified OHrQoL instrument and methodological statistical analysis approaches that could be generalised and used worldwide periodically amongst diabetic patients may also be advocated.
Classification Matters: A One Health Perspective
Authors: Lugova Halyna , Win Kyu Kyu , Haque Mainul
Published: June 2024

This paper introduces a promising ecological approach to classifying infectious diseases based on the reservoir of the causative organism. According to this approach, all infectious diseases are classified as anthroponoses, zoonoses, and sapronoses. Among these three, zoonoses are the most used and known category, including diseases naturally transmitted between vertebrate animals and humans. The principal reservoir of the pathogen is often populations of certain animal species. The term “anthroponoses” denotes diseases where human hosts are central to the pathogen’s life cycle and provide its survival from an evolutionary perspective. These diseases circulate only among humans, and animals are not susceptible to them. Finally, sapronoses is an emerging concept for categorizing diseases where the causative organisms grow saprophytically in the environment and parasitically in vertebrate hosts, including humans. However, the parasitic phase usually plays a secondary role. Recognizing infectious diseases as sapronoses highlights the role of the connection between diseases among humans, animals, and the environment. This ecological approach to classifying infectious diseases is worth exploring, especially in the context of One Health, which emphasizes the interdependence between these three dimensions. Theoretical exploration focusing on the complex dynamics of pathogen-host interactions is needed to develop this classification further.
Risk factors during admission on mortality of newborns in neonatal care units
Authors: Eita Ahmed M. , Shabana Mona A.M. , Bassiouny Mohamed R.
Published: June 2024

Background

Neonatal mortality is defined as the death of live born within the first 28 days of life. It represents a great burden on the health and community. Many risk factors are associated with neonatal mortality.

Aim

Evaluate perinatal admission risk factors and their relation to neonatal mortality in newborns admitted to neonatal care units participating in the Egyptian Neonatal Network (EGNN).

Patients and methods

This retrospective study included 4621 newborns admitted to Neonatal Care Units participating in the Egyptian Neonatal Network over 3 years (2014–2016). The record of the cases was revised to determine the maternal characteristics, the incidence of neonatal mortality, and the associated risk factors associated with mortality.

Results

Among the studied factors, increased gravidity, parity, and number of live children and lower gestational age, birth and, admission weight, length, and HC, are associated with increased neonatal mortality in neonatal intensive care unit (NICUs) (P value<0.001).

Conclusion

Determination of risk factors in neonatal death can help to identify sick neonates who are more likely to die in NICUs and provide on-time care. Help doctors to tell parents what possibly happened to their babies. And used as a tool to compare the outcome of different NICUs and evaluate their performance.
Disseminated rhinosporidial osteomyelitis: A rare case report
Authors: Behera Samira Kumar , Dhal Arpita , Singh Ruchika
Published: June 2024

Rhinosporidiosis is a chronic granulomatous disease caused by Rhinosporidium
seeberi, that affects mostly nasal and nasopharyngeal mucosa. Occurrence at extranasal sites such as cutaneous, subcutaneous, and bone is extremely rare. We hereby report a very rare case of disseminated rhinosporidial osteomyelitis.
Clear cell adenocarcinoma of the cervix and its mimickers - A series of 19 cases from a tertiary care referral centre in India
Authors: Thomas Ann , Menon Santosh , Rekhi Bharat , Mittal Neha , Deodhar Kedar
Published: June 2024

Clear cell adenocarcinoma (CCAC) of cervix is a rare subtype of endocervical adenocarcinoma that accounts for 4% of all cervical adenocarcinoma with many morphological mimickers. Retrospectively study cases of cervical clear cell adenocarcinoma of the cervix. Clinical profile and pathological features of CCAC of the cervix diagnosed between 2018-2022 were retrospectively analyzed.The database of the Department of Pathology of our institute was systematically searched for patients diagnosed with clear cell adenocarcinoma of the cervix during 2018-2022.A total of 19 patients were studied with the mean age of patients being 53.72 years (range 25 -84 yrs,standard deviation-25.9) and median tumor size being 5.6cm. Lymph node metastasis was identified in 33.3% and distant metastasis were seen in 20% of the cases. Staging could not be done in 4 cases.FIGO staging of the cases included IB1(2 cases), IB2(2 cases), IIB (3 cases),IIIA (1 case)IIIB(4 cases),and IV(3 cases). On histopathological evaluation, heterogeneous architectural pattern comprising of tubulocystic, solid, and papillary patterns were seen in 13 cases (13/19,68.4%). Pure tubulocystic (3/19,15.7%), pure papillary (2/19,10.5%), and pure solid patterns (1/19,5.3%) were also identified. Tumor cells with clear cytoplasm ranged from 5% to 95%. Nuclear atypia was moderate to marked in all the cases (19/19,100%). Mitotic activity varied from 1/10hpf to 20-22/10hpf. By immunohistochemistry, tumor was positive for Napsin A in all the cases,p16INK4a was negative in majority of cases (15/19,78.9%) and ER was negative in 14 cases (14/19,73.7%) .p53 showed wild type staining except for one case . Clear cell adenocarcinoma being a rare subtype of cervical adenocarcinoma, needs to be differentiated from other Human Papilloma Virus(HPV) independent adenocarcinomas (gastric and mesonephric types) and benign entities such as endocervical glandular Arias-Stella reaction. Judicious use of a panel of immunostains is often helpful.
Primary pulmonary angiosarcoma was misdiagnosed as IgG4-related disease by needle biopsy: A challenging case report
Authors: Wei Shufei , Han Yongliang , Hou Yingyong , Hu Jiali
Published: June 2024

Angiosarcoma is a rare soft tissue sarcoma. Primary angiosarcoma of the lung is even rarer. This case presents a patient with hemoptysis for 3 months. A chest computed tomography (CT) showed multiple patches of nodules with peripheral exudates distributed along the vascular bundles in both lungs, and the biopsy suggested IgG4 disease. However, the hemoptysis worsened for 3 days, and the patient underwent partial resection of the left upper lung, revealing eight masses of 0.5–2 cm in diameter. The tumor was composed of spindle, round, or polygonal cells arranged in bundles or sheets, and tumor cells were positive for vascular tumor markers. The patient was treated with six cycles of paclitaxel combined with gemcitabine chemotherapy, reducing the volume of the masses and improving hemoptysis.
Hep-2000 indirect immunofluorescence assay – An emerging screening tool for detection of antinuclear autoantibodies in various connective tissue disorders
Authors: Singh Arpita , Sahu Shilpi , Jadhav Neha R. , Kaur Navdeep
Published: June 2024

Background:

Connective tissue disorders (CTD’s) are a group of autoimmune disorders having multifactorial etiology, multisystem involvement and overlapping clinical features. Their prevalence has been increasing in India, with Systemic lupus erythematosus (SLE) being the most common CTD, affecting mostly females. Antinuclear Antibodies (ANA) directed against a variety of nuclear antigens detectable in the serum are used for screening, diagnoses, and monitoring of autoimmune diseases, with immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA) being the most widely used methods.

Aims:

1.To evaluate the diagnostic significance of IFA in screening of Autoimmune CTDs. 2.To study different titres and patterns shown by ANA positive samples.

Materials and Methods:

For IFA, patient’s sera is incubated with substrate cells, and bound antibodies are detected by incubation with a dye-conjugated anti-human immunoglobulin which are visualized by fluorescent microscopy and different ANA titres and patterns were analysed.

Results:

57 samples were examined for ANA by Indirect IFA, of which 21 (36.8%) were ANA positive with a female preponderance (71.9%) in the peri-menopausal age group. Most common pattern reported was Speckled followed by Homogenous. The sensitivity & specificity of IIFA was found to be comparable with ELISA.

Conclusion:

CTD’s are a group of autoimmune disorders with a plethora of clinical presentations, necessitating the need of a more specific and accurate screening test. ANA by IIFA gives patterns, which are associated with specific antibodies that help in reaching a diagnosis. ANA testing is a cost effective and non-invasive technique that can be used as a reliable screening test for Autoimmune disorders.
Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders
Authors: Qiu Qing , Yang Mengting , Gong Danfeng , Liang Haiying , Chen Tingting
Published: June 2024

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson’s disease, Alzheimer’s disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be used to treat these disorders. We concluded that there are few clinical drugs that can improve the pathology these diseases by acting on potassium or calcium ions. Although a few novel ion-channel-specific modulators have been discovered, meaningful therapies have largely not yet been realized. The lack of target-specific drugs, their requirement to cross the blood–brain barrier, and their exact underlying mechanisms all need further attention. This review aims to explain the urgent problems that need research progress and provide comprehensive information aiming to arouse the research community’s interest in the development of ion channel-targeting drugs and the identification of new therapeutic targets for that can increase the cure rate of nervous system diseases and reduce the occurrence of adverse reactions in other systems.
Complement-dependent neuroinflammation in spinal cord injury: from pathology to therapeutic implications
Authors: Saad Hassan , El Baba Bachar , Tfaily Ali , Kobeissy Firas , Gonzalez Juanmarco Gutierrez , Refai Daniel , Rodts Gerald R. , Mustroph Christian , Gimbel David , Grossberg Jonathan , Barrow Daniel L. , Gary Matthew F. , Alawieh Ali M.
Published: June 2024

Spinal cord injury remains a major cause of disability in young adults, and beyond acute decompression and rehabilitation, there are no pharmacological treatments to limit the progression of injury and optimize recovery in this population. Following the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation, a similar role for complement in spinal neuroinflammation is a focus of ongoing research. In this work, we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins, triggers of complement activation, and role of effector functions in the pathology. We study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris, and or activation via antibody binding to damage-associated molecular patterns. Several effector functions of complement have been implicated in spinal cord injury, and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord injury. Following this pathophysiological review, we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human subjects. This review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury, to evaluate the phases of involvement of opsonins and anaphylatoxins, and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.
Intraocular lens power calculation in challenging cases
Authors: Ma Jack X. , Wang Li , Koch Douglas D.
Published: June 2024

In this article, we reviewed recently published papers of intraocular lens (IOL) power calculation in special eyes. In short eyes, accurate estimation of effective lens position is critical, and the ZEISS artificial intelligence IOL calculator produces the best outcomes. In long eyes, accuracy has been improved with axial length (AL) adjusted formulas such as the Wang–Koch AL adjustment and newer IOL formulas. In keratoconic eyes, hyperopic refractive outcomes increase with steeper keratometric values, and accuracy is poor in eyes with keratometric values ≥50.0 D. Two keratoconus-specific formulas (Barrett True K for keratoconus and Kane keratoconus) have been introduced. In eyes undergoing combined Descemet membrane endothelial keratoplasty and cataract surgery, steeper corneas and corneas with a lower anterior/posterior ratio may have higher degrees of corneal flattening, and more myopia ranging from −0.75 to −1.0 D should be targeted. The postrefractive IOL power calculator from the American Society of Cataract and Refractive Surgery website has been a useful tool for postrefractive IOL power calculation. Recently, newer IOL formulas incorporating both anterior and posterior corneal measurements were introduced for eyes with previous corneal refractive surgery: Barrett True-K TK, Pearl-DGS, EVO 2.0, and Hoffer QST. It is recommended to obtain IOL calculations using as many formulas as possible and select the IOL power based on the consensus of multiple methods, with more weight given to the newer IOL power calculation formulas.
Association between Endoscopist Volume and Interval Cancers after Colonoscopy: Results from the National Colorectal Cancer Screening Program in Korea
Authors: Kim Dong Jun , Yoon Nan-He , Jun Jae Kwan , Suh Mina , Lee Sunhwa , Kim Seongju , Kim Ji Eun , Lee Hooyeon
Published: June 2024

Purpose The rate of interval colorectal cancer (iCRC) is now accepted as a key performance indicator of organized colorectal cancer (CRC) screening programs. We aimed to examine the association between endoscopist volumes and the rate of iCRC among individuals with a positive fecal immunochemical test (FIT) within a nationwide population-based CRC screening program.Materials and Methods Individuals aged ≥ 50 years who underwent colonoscopy after a positive FIT from January 1, 2019 until December 31, 2020 in the Korean National Cancer Screening Program (KNCSP) were enrolled. We converted the data into per-endoscopist screening results, calculated the iCRC rates per endoscopist, and compared them to the previous year’s annual volume that was divided into five groups (V1, 1-9; V2, 10-29; V3, 30-59; V4, 60-119; V5, ≥ 120).Results A total of 10,412 endoscopists performed 216,907 colonoscopies. Overall, the average rate of iCRC per endoscopist was 8.46 per 1,000 examinations. Compared with the group with the highest volume (V5 group), the rate of iCRC was 2.21 times higher in the V1 group. Similar trends were observed in the other groups (V2: relative risks [RR], 2.15; 95% confidence interval [CI], 1.57 to 2.94; V3: RR, 1.56; 95% CI, 1.15 to 2.13; V4: RR, 1.18; 95% CI, 0.83 to 1.67).Conclusion The findings emphasize that endoscopists with lower procedure volumes have higher risks of interval cancer being missed or undetected. To maximize the preventative impact of colonoscopy for CRC, this issue should be addressed by monitoring endoscopist volumes and variations in performances.
On topological bound states and secular equations for quantum-graph eigenvalues
Authors: Harrell II Evans M. , Maltsev Anna V.
Published: June 2024

Quantum graphs without interaction which contain equilateral cycles possess “topological” bound states which do not correspond to zeros of one of the two variants of the secular equation for quantum graphs. Instead, their eigenvalues lie in the set of singularities of the vertex-scattering secular matrix. This observation turns out to be representative of a wider phenomenon. We introduce a notion of topological bound states and show that they are linear combinations of functions supported on generators of the fundamental group of the graph (hence the “topological” in the name), including for graphs that have interactions on the edges. Using an Ihara-style theorem, we elucidate the role of such topological bound states in the spectral analysis of quantum graph Hamiltonians using secular matrices. En route we determine the set of the fixed vectors of the bond-scattering matrix.
The Effectiveness of Parenting Program Based on Video Interactive Guidance
Authors: Menteşe Babayiğit Tuğba , Çıkılı Uytun Merve , Temeltürk Rahime Duygu , Efendi Gökçe  Yağmur , Öztop Didem Behice , Yürümez Esra , Üstün Güllü Belgin , Pekacar Uyaroğlu Semiha
Published: June 2024

This study aimed to assess the impact of a video-based interactive guidance (VIG) training program on parents’ anxiety, depression levels, coping styles, and interactions with their infants. The sample comprised eight children aged 24-40 months years diagnosed with autism spectrum disorder and/or developmental delay. After the diagnostic process, the parents participated in a 4-session VIG parenting program. Pre- and post-implementation comparisons were made on various variables. Data were collected from mothers using sociodemographic forms, Beck Depression Inventory, State Trait Anxiety Inventory, The Ways of Coping Inventory, parenting attitudes styles, and Crowell procedure (PIR-GAS) scores. Our findings revealed that following VIG, the quality of parent-child relationships improved significantly compared with earlier assessments, as observed through PIR-GAS evaluations. Moreover, there was a notable decrease in ineffective coping styles among parents. The VIG outlined in this study proved to be a highly successful psychological therapy method for children and preschoolers. However, while these results are significant, evidence supporting this program’s effectiveness for mothers and children in early childhood is limited, emphasizing the need for further research.
IDENTIFIKASI LOKASI RAWAN KECELAKAAN (BLACKSPOT) DI KABUPATEN BEKASI
Authors: Fariz Umar , Kusmayadi Didik
Published: June 2024

Kabupaten Bekasi merupakan daerah penyangga ibukota serta dan menjadi daerah strategis yang dilewati oleh ruas jalan tol Jakarta – Cikampek dan jalan Pantura. Adanya kedua jalan arteri tersebut, maka kejadian kecelakaan akan berpotensi semakin meningkat. Hal ini dibuktikan dengan data IRSMS tahun 2022, jumlah kejadian kecelakaan di Kabupaten Bekasi mengalami peningkatan dalam tiga tahun terakhir (2019 – 2021) dengan jumlah 3.084 kejadian yang melibatkan 4.065 korban. Dengan meningkatnya jumlah kecelakaan, maka diperlukan identifikasi lokasi rawan kecelakaan (blackspot) dan mendiagnosis penyebab terjadinya kecelakaan. Metode yang digunakan dalam penelitian ini adalah Simple Ranking Method dan perankingan blackspot menggunakan metode Average Crash Frequency dan Equivalent Property Damage Only (EPDO) Average Crash Frequency. Dari hasil identifikasi yang telah dilakukan, diketahui tiga lokasi grid tertinggi berdasarkan frekuensi kecelakaan yang menyebabkan korban meninggal dunia dan luka berat, yaitu grid 1887 di jalan Pilar Sukatani, grid 1885 di jalan Raya Rengas Bandung (Simpang Tiga Rawakudu), dan grid 1886 di jalan Urip Sumoharjo.
THRESHOLD BERAT MUATAN MOBIL BARANG DALAM HUBUNGANNYA DENGAN JUMLAH GAYA REM PADA PENGUJIAN KEMAMPUAN REM
Authors: Ermanto Surya Aji , Sasue Riz Rifai Oktavianus , Pradana Adrian
Published: June 2024

Uji kemampuan rem utama pada kendaraan bermotor dilakukan melalui proses yang dinamakan pengujian rem (brake tester) yang dilakukan pada setiap sumbu roda di kendaraan bermotor yang diuji. Uji kemampuan rem utama tersebut dilakukan dengan menggunakan beban muatan kosong atau tanpa adanya muatan sama sekali saat proses uji rem tersebut. Hal ini jelas sangat bertolak belakang dengan kenyataan di lapangan karena mayoritas setiap kendaraan bermotor terutama dengan jenis mobil barang sesuai dengan peruntukannya selalu mengangkut barang/muatan saat beroperasi di jalan. Proses uji berkala pada pengujian rem (brake tester) yang dilakukan saat kendaraan bermotor dalam keadaan kosong tersebut, tentu tidak mencerminkan kondisi saat dioperasikan di jalan sehingga hasil uji kemampuan rem tersebut masih diragukan kemampuannya terutama saat kendaraan bermotor mengangkut barang/muatan sesuai dengan daya angkut yang telah ditetapkan. Atas dasar pemikiran di atas, maka penulis tertarik untuk membuat penelitian dengan judul “Threshold Berat Muatan Mobil Barang Dalam Hubungannya Dengan Jumlah Gaya Rem Pada Pengujian Kemampuan Rem”. Metode penelitian yang digunakan termasuk dalam penelitian eksperimen kuantitatif. Penelitian ini menghasilkan beberapa hal antara lain Hubungan antara massa dummy dengan kemampuan rem kendaraan adalah berbanding terbalik. Semakin besar massa dummy maka kemampuan rem semakin menurun; Pada pertambahan massa dummy sebesar 231 Kg kemampuan rem sudah tidak lolos uji dengan nilai 49,9 %; Persentase massa yang diangkut adalah sebesar 26,3 % dari massa kosong kendaraan agar kemampuan rem masih lolos uji; Kemampuan rem pada saat massa kosong sangat berbeda jika dibandingkan dengan saat dilakukan penambahan massa muatan. Ketika berat kosong kemampuan rem mencapai 88 % sedangkan pada pertambahan massa 250 Kg kemampuan rem turun sampai 46,3%.
La dignidad humana en las relaciones laborales. A propósito del derecho a la ocupación efectiva en el ordenamiento peruano
Authors: Espinoza Escobar Javier H
Published: June 2024

El presente artículo analiza el derecho a la ocupación efectiva en el ordenamiento laboral peruano y resalta su intrínseca vinculación con la dignidad humana. Si bien no se encuentra expresamente considerado en la norma laboral general, se plantea que forma parte del contenido del derecho al trabajo y que no solo posibilita el cumplimiento de las obligaciones asumidas por el trabajador, sino también que este pueda realizarse y contribuir al bien común. Se revisan también diversos pronunciamientos de los tribunales administrativos y judiciales en los que se otorga protección a dicho derecho, a partir de la disposición que considera como acto de hostilidad equiparable al despido todo aquel que afecte la dignidad del trabajador. En suma, el derecho a la ocupación efectiva se funda en la dignidad y, al mismo tiempo, es la herramienta para lograr una existencia digna.
Mecanismo de rehabilitación como reparación integral en el delito de femicidio en relación al marco doctrinario y el contexto legal ecuatoriano
Authors: Oleas Tapia Lisseth Estefanía , Gómez de la Torre Jarrín Gina Lucía
Published: June 2024

El presente artículo, se encuentra enfocado al estudio del mecanismo de rehabilitación como reparación integral a las víctimas indirectas del femicidio, y como este mecanismo podría ayudar con el proceso de perdida que sufren las víctimas, el enfoque que se utiliza a sido el cualitativo, ya que el método de investigación utilizado fue el descriptivo-analítico, ya que se describirá el contexto de la reparación integral, como se ha dado su desarrollo histórico y también como se ha desarrollado dentro del ámbito normativo, de igual manera se ha utilizado el método de observación natural, mediante el cual se dará el estudio de casos, específicamente de sentencias sobre el delito de femicidio con el fin de determinar si se está dando o no el mecanismo de rehabilitación a las víctimas indirectas.
Literature Review about the Intrinsic motivation in Young English as a Foreign Language LearnersLiterature Review about the Intrinsic motivation in Young English as a Foreign Language Learners
Authors: Sánchez Franco Carla Elizabeth , Pérez Ortega María Isabel
Published: June 2024

This literature review focuses on the influence of intrinsic motivation on learning, particularly among English as a Foreign Language (EFL) students. The goal is to provide theoretical support for future research and expand knowledge about the significance of intrinsic motivation and the strategies teachers can use to develop it to facilitate classroom work and promote student-centered education. The need for this study arises from the lack of motivation observed in young English learners who perceive the language as complex and not applicable in authentic contexts. This qualitative and descriptive study advanced by selecting relevant information, analyzing it, and presenting findings. The result showed that intrinsic motivation makes students enjoy the learning process, look for their strategies, and solve problems when facing challenges since the desire comes from their inner interest and their own goals. Most authors state that activities that promote automaticity help foster intrinsic motivation arising from self-esteem, self-control, and self-regulation. The specific activities proposed to get students’ self-commitment emphasize gamification, research-based projects, project-based learning, and flipped learning, mainly when focusing on social topics, facilitating students’ interaction with the target language and instilling confidence in their abilities.
Analysis of the Reception of Sexual Violence in Like & Share Films
Authors: Budiman Arif Imam , Wibowo Arif Ardy
Published: June 2024

Sexual violence is a very troubling phenomenon in society because it can cause physical, sexual, and psychological suffering for victims. In Indonesia, several films have raised the theme of sexual violence inspired by true stories, one of which is a teen drama film entitled Like & Share. This study aims to understand how the audience interprets and responds to sexual violence in the movie. The method used is descriptive semi-structured qualitative research with Stuart Hall's reception analysis. Data were collected through interviews and documentation from ten informants aged 18-24, who were classified into three reception categories: dominant hegemonic position, negotiated position, and oppositional position. The results showed that five informants were in the dominant hegemonic position category, which means they agreed with the movie's message regarding sexual violence. Three informants were in the negotiated position category, indicating they agreed but added personal views. Two informants were in the oppositional position category, showing their disagreement with the movie's message.