bluuebunny/crossref_metadata_2025 huggingface dataset:
Standard ECG in Brugada Syndrome as a Marker of Prognosis: From Risk Stratification to Pathophysiological Insights
Authors: Vitali Francesco , Brieda Alessandro , Balla Cristina , Pavasini Rita , Tonet Elisabetta , Serenelli Matteo , Ferrari Roberto , Delise Pietro , Rapezzi Claudio , Bertini Matteo
Published: May 2021

Background

The 12‐lead ECG plays a key role in the diagnosis of Brugada syndrome (BrS). Since the spontaneous type 1 ECG pattern was first described, several other ECG signs have been linked to arrhythmic risk, but results are conflicting.

Methods and Results

We performed a systematic review to clarify the associations of these specific ECG signs with the risk of syncope, sudden death, or equivalents in patients with BrS. The literature search identified 29 eligible articles comprising overall 5731 patients. The ECG findings associated with an incremental risk of syncope, sudden death, or equivalents (hazard ratio ranging from 1.1–39) were the following: localization of type 1 Brugada pattern (in V2 and peripheral leads), first‐degree atrioventricular block, atrial fibrillation, fragmented QRS, QRS duration >120 ms, R wave in lead aVR, S wave in L1 (≥40 ms, amplitude ≥0.1 mV, area ≥1 mm
2
), early repolarization pattern in inferolateral leads, ST‐segment depression, T‐wave alternans, dispersion of repolarization, and Tzou criteria.

Conclusions

At least 12 features of standard ECG are associated with a higher risk of sudden death in BrS. A multiparametric risk assessment approach based on ECG parameters associated with clinical and genetic findings could help improve current risk stratification scores of patients with BrS and warrants further investigation.

Registration

URL:
https://www.crd.york.ac.uk/prospero/
. Unique identifier: CRD42019123794.
A large-scale validation of the relationship between cross-disciplinary research and its uptake in policy-related documents, using the novel Overton altmetrics database
Authors: Pinheiro Henrique , Vignola-Gagné Etienne , Campbell David
Published: May 2021

Cross-disciplinary research (multi-/interdisciplinarity) is incentivized by funding agencies to foster research outcomes addressing complex societal challenges. This study focuses on the link between cross-disciplinary research and its uptake in a broad set of policy-related documents. Using the new policy-oriented database Overton, matched to Scopus, logistic regression was used in assessing this relationship in publications from FP7- and H2020-supported projects. Cross-disciplinary research was captured through two lenses at the paper level, namely from the disciplinary diversity of contributing authors (DDA) and of cited references (DDR). DDA increased the likelihood that publications were cited in policy documents, with DDR possibly making a contribution, but only when publications result from the work of few authors. Citations to publications captured by Overton were found to originate in scientific advice documents, rather than in legislative or executive records. Our approach enables testing in a general way the assumption underlying many funding programs, namely that cross-disciplinary research will increase the policy relevance of research outcomes. Findings suggest that research assessments could benefit from measuring uptake in policy-related literature, following additional characterization of the Overton database; of the science-policy interactions it captures; and of the contribution of these interactions within the larger policymaking process.
Owning Virtue
Authors: Piñeros Glasscock Allison
Published: May 2021

At the end of the Meno, Socrates suggests that genuine virtue is knowledge. This is surprising because he has recently concluded that virtue is (mere) true opinion. I show that Socrates’ new position is motivated by two commitments. First, that being virtuous requires being responsible for the correctness of one’s actions. Second, that only a knower has this kind of ownership of action. An implication of my argument is that, despite his emphasis on virtuous action in the Meno, Socrates endorses an agent-centred ethics. He thinks the epistemic status of the agent is essential to the assessment of her goodness.
Catching John in Four Nets? Competition, Qumran, Sacramentalism and Messianism
Authors: Adinolfi Federico , Taylor Joan
Published: May 2021

In his recent study on John the Baptist Joel Marcus suggests that John founded a sect that was in competition with the early Jesus movement. Marcus also suggests that John himself was a former member of the 'Qumran community'. His baptism is considered as a kind of sacrament in which the Holy Spirit was imparted. How secure are these proposals? In this discussion, we conclude that in the oldest literary witnesses – Q, Mark and Matthew – the relationship between John and Jesus is seen in terms of mutual agreement (despite Jesus’s obvious superiority) and there are no recognizable traces of serious competition with John’s disciples, even less a ‘Baptist sect’. The evidence used by Marcus to suggest that John was once a member of the ‘Qumran community’ connects John with broader patterns of thought in Second Temple Judaism, not simply sectarians at one location. That John imparted the Holy Spirit in a sacramental rite can only be supported by radically altering biblical readings. However, Marcus has suggested that in light of all this that John thought of himself not only as Elijah but as a kind of Messiah, with the role of his successor, the Coming One, being to destroy the chaff. In doing this, Marcus redesigns John as a kind of alternative Christ of Faith. However, the underlying ‘competition model’ needs to be rejected and replaced with one that sees Jesus as claiming to be a successor to John, his highly esteemed teacher.
Naturalizing Christians: A Response to Joel Marcus, John the Baptist in History and Theology
Authors: Roberts Erin
Published: May 2021

This essay examines the conceptual framework that informs Marcus’s distinction between history and theology, and considers what stands to be gained by this manner of classification. The essay observes that Marcus’s classification hinges upon a theory of religion that views gospels as artifacts expressive of sincere belief and, further, suggests this approach serves to mystify the origins of the Christian theological metanarrative by replicating the explanation asserted within the gospels themselves. By reversing the conceptual framework and the explanatory priority, one could deploy a theory of religion that sees gospels as artifacts of persuasion and thereby argue that they aim to naturalize the initially unnatural truth claim that Jesus was the christ by connecting him to a known social type: John. From this approach, it would not be belief in Jesus as the christ that explains the modified constructions of John the Baptist; rather, modifications of John the Baptist would be precisely what construct belief in Jesus as the christ.
Virtue, Knowledge, and Political Instability in Aristotle’s Politics: Lessons from the Eudemian Ethics
Authors: Miller Benjamin
Published: May 2021

I argue that we cannot fully understand Aristotle’s position on political stability and state preservation in the Politics with paying close attention to his Eudemian Ethics. We learn from considering the Politics and the Eudemian Ethics in concert that even ‘correct’ regimes are unstable when citizens do not possess full virtue. Aristotle introduces his formal account of the knowledge requirements for virtue in Eudemian Ethics 8.3, and he applies these knowledge requirements as an explanation for state decline in Politics 2.9 when discussing the Spartans. If we primarily focus on the Nicomachean Ethics as Aristotle’s single essential ethical work, we will not learn the lesson he intends his readers to take away from the Spartan discussion in the Politics: that virtue requires correct understanding of the hierarchy and structure of the good life. This knowledge prevents the erosion of the virtues of character and the decline of political regimes.
Comparative Global Humanities Now
Authors: Denecke Wiebke
Published: May 2021

This essay proposes to energize the mission of the humanities by radically globalizing their subject matter and methods, taking inspiration from the world’s monumental archive of humanistic creativity over 5000 years of recorded experience. It advocates for Comparative Global Humanities as a crucial complement to the more presentist new humanities fields of medical, environmental, or public humanities. Comparative Global Humanities aims to be inclusively global in terms of subject matter and participants, conceptually comparative, and based on rigorous historical and philological research. A Global Humanities for the 21st century is no antiquarian endeavor, but a head-on response to the greatest challenges of our times: systemic racism, inequality, and fundamentalisms, which are rooted in the unresolved aftermath of wars, colonization, and violence, and use classical heritage for nationalist propaganda. To create more equal societies in the present we need to create more equality for other pasts – and learn from all they offer.
Study on the Application of a Novel Nano-Curcumin Drug for Alzheimer’s Disease
Authors: Yang Liu , Sun Xin , Huang Jun , Zhu Shimiao , Li Yan
Published: May 2021

Alzheimer’s disease (AD) is a neurodegenerative disease hallmarked by impaired cognitive function and memory decline; it is accompanied by a variety of mental symptoms and behavioral disorders. This disease has a serious impact on society, families, and the afflicted patients.
Curcumin (Cur) nanoparticles were preparation by modifying curcumin with polyethylene glycol-polylactic acid (PEG-PLA) amphiphilic block copolymer. The resulting nanodrug can successfully penetrate the blood brain barrier (BBB) and concentrate in the main pathological areas of AD. As measured
with a Zeta particle size analyzer, the particle size of PEG-PLA/Cur was 100 ± 0.53 nm, and it was electrically neutral. In vitro experiments revealed that PEG-PLA/Cur successfully penetrated the membrane of PC12 cells and inhibited proliferation. PEG-PLA/Cur also exhibited an
inhibitory effect on the production of amyloid β protein (Aβ fiber) and depolymerization activity on Aβ fiber aggregates. PEG-PLA/Cur represents a novel nanodrug with the potential to treat AD.
The asymmetric influence of ocean heat content on ENSO predictability in the CNRM-CM5 coupled general circulation model
Authors: Planton Yann Y. , Vialard Jérôme , Guilyardi Eric , Lengaigne Mathieu , McPhaden Michael J.
Published: May 2021

Unusually high western Pacific oceanic heat content often leads to El Niño about 1 year later, while unusually low heat content leads to La Niña. Here, we investigate if El Niño Southern Oscillation (ENSO) predictability also depends on the initial state recharge, and discuss the underlying mechanisms. To that end, we use the CNRM-CM5 model, which has a reasonable representation of the main observed ENSO characteristics, asymmetries and feedbacks. Observations and a 1007-years long CNRM-CM5 simulation indicate that discharged states evolve more systematically into La Niña events than recharged states into neutral states or El Niño events. We ran 70-members ensemble experiments in a perfect-model setting, initialized in boreal fall from either recharged or discharged western Pacific heat content, sampling the full range of corresponding ENSO phases. Predictability measures based both on spread and signal-to-noise ratio confirm that discharged states yield a more predictable ENSO outcome one year later than recharged states. As expected from recharge oscillator theory, recharged states evolve into positive central Pacific sea surface temperature anomalies in boreal spring, inducing stronger and more variable Westerly Wind Event activity and a fast growth of the ensemble spread during summer and fall. This also enhances the positive wind stress feedback in fall, but the effect is offset by changes in thermocline and heat flux feedbacks. The state-dependent component of westerly wind events is thus the most likely cause for the predictability asymmetry in CNRM-CM5, although changes in the low-frequency wind stress feedback may also contribute.
Design and Evaluation of Calibrated and Seamless Ensemble Weather Forecasts for Crop Protection Applications
Authors: Aleksovska Ivana , Raynaud Laure , Faivre Robert , Brun François , Raynal Marc
Published: May 2021

Agriculture is a highly weather-dependent activity, and climatic conditions impact both directly crop growth and indirectly diseases and pest developments causing yield losses. Weather forecasts are now a major component of various decision-support systems that assist farmers to optimize the positioning of crop protection treatments. However, properly accounting for weather uncertainty in these systems still remains a challenge. In this paper, three global and regional ensemble prediction systems (EPSs), covering different spatiotemporal scales, are coupled to a temperature-driven developmental model for grapevine moths in order to provide probabilistic forecasts of treatment dates. It is first shown that a parametric postprocessing of the EPSs significantly improves the prediction of treatment dates. Anticipating the need for phytosanitary treatments also requires seamless weather forecasts from the next hour to subseasonal time scales. An approach is presented to design seamless ensemble forecasts from the combination of the three EPSs used. The proposed method is able to leverage the increased performance of high-resolution EPS at short ranges, while ensuring a smooth transition toward larger-scale EPSs for longer ranges. The added value of this seamless integration on agronomic predictions is, however, difficult to assess with the current experimental setup. Additional simulations over a larger number of locations and years may be required.
The Impact of Medical Comorbidities on Patient Satisfaction in Chronic Rhinosinusitis
Authors: Gill Amarbir S. , Hwang Joshua , Beliveau Angela M. , Alt Jeremiah A. , Strong Edward Bradley , Wilson Machelle D. , Steele Toby O.
Published: May 2021

Background:

Patient satisfaction has a significant bearing on medical therapy compliance and patient outcomes. The purpose of this study was to (1) describe patient satisfaction, as characterized by the Patient Satisfaction Questionnaire-18 (PSQ-18), in the care of patients with chronic rhinosinusitis (CRS) and (2) analyze the impact of comorbidities on satisfaction using the functional comorbidity index (FCI).

Methods:

Patient demographics, disease severity measures, and PSQ-18 scores for patients with CRS presenting to a tertiary rhinology clinic between November 2019 and April 2020 were collected and analyzed. FCI was calculated retrospectively using the electronic medical record; individual comorbidities were tabulated. Spearman’s correlations followed by multivariate regression was used to assess the relationship between medical comorbidities and PSQ-18.

Results:

Sixty-nine patients met criteria for analysis. There were no significant differences in age, gender, and Sinonasal Outcomes Test-22 scores between CRS patients with (CRSwNP) and without (CRSsNP) nasal polyps. There was no significant difference in the mean FCI for patients with CRSwNP versus CRSsNP (5.1 and 4.3, respectively) ( P = .843). Similarly, there was no significant difference in the mean sum PSQ-18 score (78/100 in both) between these cohorts ( P = .148). The mean sum PSQ-18 score was not significantly associated with anxiety ( P = .728), depression ( P = .624), or FCI ( P = .282), but was significantly associated with hearing impairment ( P < .001).

Conclusion:

Patient satisfaction in the care of CRS is generally high with a diagnosis of comorbid hearing impairment demonstrating a negative association with satisfaction in this cohort.
Cigarette Smoke Exposure Inhibits Osteoclast Apoptosis via the mtROS Pathway
Authors: Qin Y. , Liu Y. , Jiang Y. , Mei S. , Liu Y. , Feng J. , Guo L. , Du J. , Graves D.T. , Liu Y.
Published: May 2021

It is widely known that smoking is a risk factor for bone loss and plays a key role in osteopenia. Despite this well-known association, the mechanisms by which smoking affects bone have not been definitively established. Since smoking increases bone loss and potentially affects bone resorption in response to mechanical force, we investigated the impact of cigarette smoke on osteoclast numbers and underlying mechanisms in a mouse model of orthodontic tooth movement (OTM). The experimental group was exposed to once-daily cigarette smoke while the control group was not, and tooth movement distance and osteoclast numbers were assessed. In addition, the effect of cigarette smoke extract (CSE) on osteoclast precursor proliferation and osteoclast apoptosis was assessed in vitro. We found that cigarette smoke exposure enhanced bone remodeling stimulated by mechanical force and increased osteoclast numbers in vivo. Also, CSE increased the number of osteoclasts by inhibiting osteoclast apoptosis via the mitochondrial reactive oxygen species/cytochrome C/caspase 3 pathway in vitro. Moreover, exposure of mice to cigarette smoke affected bone marrow cells, leading to increased formation of osteoclasts in vitro. This study identifies a previously unknown mechanism of how smoking has a detrimental impact on bone.
COVID-19 Surveillance for Local Decision Making
Authors: Hyder Ayaz , Trinh Anne , Padmanabhan Pranav , Marschhausen John , Wu Alexander , Evans Alexander , Iyer Radhika , Jones Alexandria
Published: May 2021

Objective

Data-informed decision making is valued among school districts, but challenges remain for local health departments to provide data, especially during a pandemic. We describe the rapid planning and deployment of a school-based COVID-19 surveillance system in a metropolitan US county.

Methods

In 2020, we used several data sources to construct disease- and school-based indicators for COVID-19 surveillance in Franklin County, an urban county in central Ohio. We collected, processed, analyzed, and visualized data in the COVID-19 Analytics and Targeted Surveillance System for Schools (CATS). CATS included web-based applications (public and secure versions), automated alerts, and weekly reports for the general public and decision makers, including school administrators, school boards, and local health departments.

Results

We deployed a pilot version of CATS in less than 2 months (August–September 2020) and added 21 school districts in central Ohio (15 in Franklin County and 6 outside the county) into CATS during the subsequent months. Public-facing web-based applications provided parents and students with local information for data-informed decision making. We created an algorithm to enable local health departments to precisely identify school districts and school buildings at high risk of an outbreak and active SARS-CoV-2 transmission in school settings.

Practice Implications

Piloting a surveillance system with diverse school districts helps scale up to other districts. Leveraging past relationships and identifying emerging partner needs were critical to rapid and sustainable collaboration. Valuing diverse skill sets is key to rapid deployment of proactive and innovative public health practices during a global pandemic.
Experimental study on temperature drop during roller quenching process of large-section ultra-heavy steel plate
Authors: Fu Tianliang , Deng Xiangtao , Tian Xiuhua , Liu Guohuai , Wang Zhaodong
Published: May 2021

Large-section ultra-heavy steel plates feature low cooling rate of central part during quenching process, as well as great differences in texture and performance along thickness direction. Wet jet impingement quenching test apparatus and multi-channel temperature recorder were developed to explore the temperature drop characteristics and its influential factors of ultra-heavy steel plate. The temperature drop curves of plates with different thickness (160, 220, and 300 mm) and weight (23–43 tons) were recorded during the quenching process, accompanied with the exploration on distribution rules of temperature gradient, heat flux density and cooling rate along thickness direction under different water volumes (9000–9400 m3/h) and pressures (0.4–0.8 MPa), upon which the three-dimensional inverse heat conduction model, surface heat transfer coefficient model and thermophysical parameter model were established using finite element and optimization methods. The overall results indicate the symmetric heat transfer between the upper and lower plate surfaces can be realized, when the water flow ratios of the upper and lower surfaces were 1:1.25 and 1:1.4 under pressures of 0.8 MPa and 0.4 MPa, respectively. The “temperature return” phenomenon was accompanied with changing heat flux density of wall surface of 220 mm- and 300 mm-thick plates. The lowest cooling rate along thickness direction appeared at 1/4 thickness position for the 160 mm- and 220 mm- thick plates during quenching, which was attributable to the synergy between heat flux density and temperature gradient. This work may pave a way for improving the cooling rate and quenching uniformity of ultra-heavy steel plates along thickness direction.
Internal ballistics of polygonal and grooved barrels: A comparative study
Authors: Silva-Rivera Usiel S , Zúñiga-Avilés Luis Adrian , Vilchis-González Adriana H , Tamayo-Meza Pedro A , Wong-Angel Wilbert David
Published: May 2021

As a parameter important ballistic, the research about polygonal and grooved barrels’ behavior has not been widely carried out. The pressures, velocities, stresses, deformations, and strains generated by the firing of 9 mm × 19 mm ammunition in weapons with polygonal barrels are analyzed numerically and experimentally, compared with those generated in pistols with grooved barrels. The Finite Element Method with equal boundary and loading conditions was used in both types of guns, specifying the actual materials of the projectile and the barrels. Subsequently, experimental tests were carried out on various weapons with 9 mm ammunitions of 115, 122, and 124 gr. The results show that the 9 mm bullet fired in a polygonal barrel undergoes a maximum deformation towards its exterior of 0.178 mm and interior of 0.158 mm, with stress up to 295.85 MPa. Compared with 0.025 mm maximum external deformation and 0.112 mm internal deformation of 9 mm projectiles fired in a grooved barrel, with stress up to 269.79 MPa. The deformation in the polygonal barrel is in a greater area, but the rifling impression left is less deep, making its identification more difficult. Although there are differences in the stresses and strains obtained, similar velocity and pressure parameters are achieved in the two types of barrels. This has application in the development and standardization of new kinds of barrels and weapons.
Image of the environmental scientist
Authors: Yang Daihu , Yao Chengli , Zhou Minghui , Sun Xian
Published: May 2021

The environmental scientist has been playing an important role in preventing and mitigating environmental pollution. Individuals’ images of the environmental scientist will likely impact and meditate their interest and attitudes toward environmental science as well as their willingness to take up an environmental science profession. However, prior studies focusing on the image of a professional are primarily of the general scientist. The environmental scientist and the image thereof remains out of the limelight of environmental science community and has been under-researched. In this article, on the basis of the retrospect on the stereotypical images of the general and environmental scientist and the gaps in previous studies, we attempted to report young individuals’ images of the environmental scientist in an alternative context. Drawing technique was employed and administered to 127 junior students aged from 13 to 15 year-old from a junior high school. The individuals’ image of environmental scientists can be generally abstracted as a male with environmental protection knowledge and commitment to environmental protection who does work more like a green chemist, ecology restorer, or plant protector and observes or cleans outdoors, primarily in forest, jungle, and/or by riverside.
Accurate Operative Time Prediction in Thyroid Surgery: A Rural Tertiary Care Facility Experience
Authors: Stavrides Kevin P. , Lindemann Timothy L. , Harlor Evan J. , Haugen Thorsen W. , Purdy Nicholas
Published: May 2021

Objective:

To determine whether surgeons can estimate thyroid operative time more accurately than a system-generated average time estimate.

Methods:

Four otolaryngologists at a single institution with extensive endocrine surgery experience were asked to predict their operative times for all eligible thyroid surgeries. These estimates were compared to system-generated operative time predications based on averaging the surgeon’s previous 10 cases with the same Current Procedural Terminology code. The surgeon-generated estimations and system-generated estimations were then compared to each other and the actual operative time.

Results:

A final sample of 73 cases was used for all analyses. Average age was 51 years old and the majority of patients were female. Surgeon-generated operative time estimates were significantly more accurate than system-generated estimates based on time averaging ( P < .001). These findings were consistent across each surgeon individually and within each procedure type (hemithyroidectomy and total thyroidectomy). These findings had a power of over 99% based on mean differences.

Conclusion:

As the financial center of modern hospitals, an efficient operating room is integral to economic success. Improving the precision of operative time estimation reduces costly unplanned staff overtime, canceled cases, and underutilization. Our research at a rural tertiary care center shows that experienced thyroid surgeons can substantially reduce the error of estimating thyroid operative times by considering individual patient characteristics. Although no objective variables have so far been identified to correlate with thyroid operative time, surgeon-generated operative time estimation is significantly more accurate than a generic system approach of averaging previous operative times.
Multi-agent-based hybrid peer-to-peer system for distributed information retrieval
Authors: Pouamoun Abdel Naser , Kocabaş İlker
Published: May 2021

With the increasingly huge amount of data located in various databases and the need for users to access them, distributed information retrieval (DIR) has been at the core of the preoccupations of a number of researchers. Indeed, numerous DIR systems and architectures have been proposed including the broker-based architecture. Moreover, providing DIR with more flexibility and adaptability has led researchers thinking to build DIR with software agents. Thus, this research proposes a design and an implementation of a novel system based on the broker-based architecture and the peer-to-peer (P2P) network called broker-based P2P network. The proposed architecture is implemented with a multi-agent system (MAS) where the main agent playing the role of the broker, receives query from a peer agent and forwards them to other peer agents each with their index and resources. Upon completing retrieval process at each peer agent, results are directly sent to the peer agent that initiated the query without using the broker agent. Java Agent DEvelopment framework (JADE) is used to implement the agents and, for experiments, TERRIER (TERabyte RetRIEveR) is extended and used as the search engine to retrieve the Text Retrieval Conference (TREC) collections dataset notably TREC-6. The peer agent that originated the query progressively collects results coming from other peer agents, normalises and merges them and then proceeds with re-ranking. For normalisation, MinMax and Sum that are unsupervised normalisation methods are used.
Invasive thymoma – Which patients benefit from post-operative radiotherapy?
Authors: Muslim Zaid , Baig Mirza Zain , Weber Joanna F , Detterbeck Frank C , Connery Cliff P , Spera John A , Bhora Faiz Y
Published: May 2021

Background

The aim of this study is to identify patients with thymoma who should receive post-operative radiotherapy.

Methods

The Surveillance, Epidemiology, and End Results database was queried for stage IIB–IV thymoma patients diagnosed during 1988–2015. We analyzed the prognostic implications of various clinical–pathological factors by comparing the outcomes of those who received surgery with and without post-operative radiotherapy.

Results

A total of 1120 patients were identified; 62% received post-operative radiotherapy and 38% underwent surgery alone. In a propensity-matched cohort of 812 patients, no survival difference was seen in World Health Organization A, AB, B1, B2, or B3 tumors with the addition of post-operative radiotherapy to surgery (p>0.05). Post-operative radiotherapy also did not improve survival over surgery alone for tumors ≥ or < less than the 4 cm, 7 cm, 10 cm, and 13 cm cutoffs, all p>0.05. Post-operative radiotherapy was an independent, positive prognostic indicator only in the subgroup with stage III disease and in those receiving chemotherapy in addition to post-operative radiotherapy, both p<0.05.

Conclusions

Patients with stage III thymoma are most likely to benefit from the addition of post-operative radiotherapy to surgical treatments. Tumor size or World Health Organization histology alone should not be criteria for determining the need for post-operative radiotherapy in locally advanced thymoma. Masaoka–Koga stage, which has traditionally been used to help make such decisions, appears to be the most reliable determinant of the use of post-operative radiotherapy.
Clinical and surgical analysis of lobectomy for destroyed lobe of the lung: A series of 47 patients
Authors: Kabiri El Hassane , Hammoumi Massine El , Bhairis Mohamed , Oueriachi Faycal El , Slaoui Omar , Amraoui Mouaad
Published: May 2021

Objective

Destroyed lobe of the lung is always secondary to chronic or recurrent lung infections with irreversible damage of pulmonary parenchyma. In this study, we analyzed surgical technique, post-operative complications, mortality, and long-term outcomes of patients undergoing lobectomy of pulmonary lobe destruction.

Materials and methods

A retrospective study of 47 patients that underwent lobectomy due to a destroyed lung parenchyma between January 2010 and December 2019 were reviewed with an average follow-up period of 39 months.

Results

The study included 47 patients with a mean age of 39.4 years. The etiology of lobe destroyed was tuberculosis in 15 (31.9%), non-tuberculosis bronchiectasis in 20 (42.5%), aspergilloma in 09 (19.1%), hydatid cyst in 2 (4.3%), and a mis-diagnosed intrabronchic foreign body in 1 (2.1%). Surgical approach was through posterolateral thoracotomy in 44 (93.6%) patients and video-assisted thoracoscopic surgery in only 3 patients. Mean operative time was 153 min and mean post-operative hospital stay was 7.9 days. The post-operative complications occurred in five (10.6%): atelectasis (n  =  2), wound site infection (n = 1), prolonged air leak (n = 1), and hemothorax in one case. No post-operative mortality was noted. A good clinical result was observed in 87.2% of cases.

Conclusion

Surgical treatment of destroyed lobe is a high risk associated surgery. Tuberculosis and aspergilloma are the most common etiologies. Favorable result was obtained in selected patient with an excellent perioperative care.
Perceptions and experiences of older patients and healthcare professionals regarding shared decision-making in pulmonary rehabilitation: A qualitative study
Authors: Jiang Yuyu , Guo Jianlan , Sun Pingping , Chen Zhongyi , Liu Fenglan , Wang Shanshan , Ding Zhaosheng
Published: May 2021

Objective:

To understand the perceptions and experiences of older patients with chronic obstructive pulmonary disease (COPD) and healthcare professionals (HCPs) regarding shared decision-making in pulmonary rehabilitation (PR).

Design:

A qualitative study using single, semi-structured interviews, and thematic analysis.

Setting:

Face-to-face interviews were conducted in the Jiangnan University, in hospital and in patients’ homes.

Participants:

Twenty-two older patients with COPD and 29 HCPs.

Methods:

An initial codebook and semi-structured interview guide were developed based on the shared decision-making 3-circle conceptual model. Thematic analysis was used to analyze data.

Results:

The study identified 10 themes that describe the perceptions and experiences of patients and HCPs involved in PR decision-making: (1) patients’ confidence, (2) patients’ perceptions of the cost-benefit of decisions, (3) patients’ perceived stress about the consequences of decision-making, (4) HCPs’ perceived stress on shared decision-making, (5) cognitive biases of patients toward illness and rehabilitation, (6) shared decision-making as a knowledge gap, (7) the knowledge gap between patients and HCPs, (8) authority effect, (9) family support, (10) human resources. These themes were then divided into three groups according to their characteristics: (1) the feelings of the participants, (2) knowledge barriers, and (3) support from the social system.

Conclusion:

Patients and HCPs described their negative perceptions and experiences of participating in decision-making in PR. The implementation of shared decision-making in PR is currently limited; therefore, health education for patients and families should be strengthened and a training system for HCPs in shared decision-making should be established.
Speculative urbanism and the urban-financial conjuncture: Interrogating the afterlives of the financial crisis
Authors: Goldman Michael
Published: May 2021

This article proposes an analytical–methodological approach to understand this historical conjuncture of speculative urbanism in which global finance capital plays an increasingly important role in urban transformation. Whereas the scholarship on urban financialization makes sharp distinctions between what occurs in the global North and the South, portraying the process in the South as one of subordination or peripheralization and in the North as mature and stable (although volatile), this article seeks to demonstrate that the North–South divide is less effective as an explanatory power. Instead, it presents an analytical approach that is attuned to the relentless dynamism and inter-scalar hyper-mobility of finance capital working across the postcolonial map—in other words, a relational–conjunctural approach. The article suggests the method of “following the financial strategy” by analyzing urban forms and projects as processes constituted by the nexus of practices in finance and city planning. It looks closely at finance’s use of inter-scalar financial tools (such as arbitrage, interest rate swaps, collateralized debt obligations, and currency hedges) across borders, sectors, infrastructures, and conditions, as mediated by national and international state actors. The value of this analytical–methodological approach will be illustrated through notable financial transactions occurring in and across cities to emphasize their speculative and financial characteristics—specifically highlighting investments traversing cities of Spain, the USA, and India. The focus here is on financial strategies emerging from the detritus of the 2008 global financial crisis and shaped by the expanding discursive-material formation of speculative urbanism.
Director independence: Going beyond misaligned incentives to resource dependence
Authors: Hom Conan , Samson Danny , Cregan Christina , Cebon Peter
Published: May 2021

Board director independence is critical to achieving and maintaining control to address the agency theory–based issue of interest misalignment between the principal (the organization) and the executives (agent). However, theoretical and empirical research and strategic risk considerations have brought into question the role or relevance that director independence plays in these control task and agency theory domains. We ask, using a quantitative survey method, whether board activity–based applications of independence may be associated with the service task of the board, namely its resource dependence mission. Our findings suggest that the resource dependence duty of the board may be positively associated with some autonomous activities, and yet other activities might be driven primarily by normative practices. Based on this, we suggest that a theoretical scope beyond and greater than agency theory may be needed when reassessing the role of director independence.

JEL Classification: M1, O3
Does time-varying illiquidity matter for the Indian stock market? Evidence from high-frequency data
Authors: Bhattacharya Mousumi , Bhattacharya Sharad Nath , Jha Sumit Kumar
Published: May 2021

This article examines variations in illiquidity in the Indian stock market, using intraday data. Panel regression reveals prevalent day-of-the-week, month, and holiday effects in illiquidity across industries, especially during exogenous shock periods. Illiquidity fluctuations are higher during the second and third quarters. The ranking of most illiquid stocks varies, depending on whether illiquidity is measured using an adjusted or unadjusted Amihud measure. Using pooled quantile regression, we note that illiquidity plays an important asymmetric role in explaining stock returns under up- and down-market conditions in the presence of open interest and volatility. The impact of illiquidity is more severe during periods of extreme high and low returns.

JEL Classification: G10, G12
A case of a high-flow priapism treated with superselective transcatheter embolization
Authors: Cakiroglu Basri , Kaya Cevdet , Aksoy Suleyman Hilmi
Published: May 2021

High-flow priapism is a rare condition characterized by prolonged and painless erection. It is defined as contusion or thrombosis of the cavernous body of the penis usually secondary to blunt trauma. Due to the rarity of the disease, there is no well-defined consensus about treatment. Conservative treatment is often applied with non-steroidal anti-inflammatory drug. We present a case of 58-year-old man with proximal partial priapism that developed secondary to blunt trauma to the penis. The patient did not benefit from non-steroidal anti-inflammatory drug therapy and then was successfully treated with selective embolization.
The driven flow vacuum infusion process: An overview and analytical design
Authors: Morán Juan Ignacio , Ludueña Leandro Nicolás , Stocchi Ariel Leonardo , Basso Alejandro Daniel , Francucci Gaston
Published: May 2021

This article describes a novel variant of the vacuum infusion process based on a multifunctional elastomeric reusable vacuum bag. The main innovation of this process is an elastomeric membrane having resin flow channels that can be controlled during the infusion process: they can be activated for the impregnation stage to enhance resin flow and removed during the curing stage to provide a smooth surface finish to the part. In addition, the size of the resin flow channels can be modified during the infusion providing control on the impregnation rate. This article describes the driven flow vacuum infusion (DFVI) process and presents analytical calculations regarding the effect of the geometrical design of the membrane and the processing variables on the porosity, permeability, and volume of resin transported by the flow medium. Preliminary results of unidirectional resin infusion tests comparing the DFVI process to traditional vacuum infusion and SCRIMP are also presented.
Debasement of Merit: The Method and Experience of Political Discrimination by Public Employees in the Commonwealth of Puerto Rico
Authors: Pérez-Chiqués Elizabeth , Rubin Ellen V.
Published: May 2021

While most democratic governments include some political appointees at the top of agencies for the sake of bureaucratic accountability, too much patronage decreases government performance. Puerto Rico has all of the components for a robust merit system on paper, but it is consistently undermined, with significant negative consequences for public employees. Based on an inductive analysis of 29 in-depth interviews with public employees and 50 political discrimination court cases, this article shows how an informal patronage system is implemented by incorporating political information into personnel decisions. The pervasiveness of this system results in employees being categorized as either insiders or outsiders, where outsider status is accompanied by harassment, ostracizing, and other negative changes in working conditions. These shifts in status sustain patronage practices by crystalizing political identity, which increases partisan polarization, and provides a rationale and justification for future politically discriminatory actions.
Oral Methadone for Patients With Neuropathic Pain Due to Neoplastic Brachial Plexopathy
Authors: Matsuda Yoshinobu , Okayama Sachiko
Published: May 2021

Background: The brachial plexus nerves originate from the cervical (C5-C8) and first thoracic (T1) spinal nerves, and innervate muscles and skin of the chest, shoulder, arm and hand. Brachial plexus injuries can occur as a result of shoulder trauma and inflammation. Malignant tumors can also cause neoplastic brachial plexopathy (NBP), and refractory neuropathic pain is the most common symptom of NBP. Methadone is a synthetic opioid with high efficacy as an opioid-receptor agonist, and its inhibitory effects on N-methyl-D-aspartate (NMDA) may play a role in pain relief. However, there is a need to examine if oral methadone exhibits safety and efficacy against neuropathic pain due to NBP. Case Presentations: NBP was diagnosed in 3 cases without brain or cervical spine metastasis. The clinical features of these patients were analyzed retrospectively. None of the cases had an indication for surgery because of advanced cancer and all had received radiation therapy that had an insufficient effect, prior to methadone treatment. All 3 patients had nociceptive and neuropathic pain. Methadone for refractory pain was initiated using the stop-and-go method. NRS pain scores decreased in all cases and there were no severe side effects. Discussion: For the purpose of pain relief, patients with NBP may receive surgery, radiation therapy and nerve block, but these are not always effective. Methadone was recently shown to be superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer in a RCT, and our findings suggest that methadone may also be effective for patients with NBP. Conclusion: More studies are necessary, but results in 3 cases suggest that oral methadone may be a safe analgesic agent for patients with neuropathic pain due to NBP.
Gender Moderates the Association Between Exposure to Interpersonal Violence and Intermittent Explosive Disorder Diagnosis
Authors: Krick Lynette C. , Berman Mitchell E. , McCloskey Michael S. , Coccaro Emil F. , Fanning Jennifer R.
Published: May 2021

Exposure to interpersonal violence (EIV) is a prevalent risk-factor for aggressive behavior; however, it is unclear whether the effect of EIV on clinically significant aggressive behavior is similar across gender. We examined whether gender moderates the association between experiencing and witnessing interpersonal violence and the diagnosis of intermittent explosive disorder (IED). We also examined potential pathways that might differentially account for the association between EIV and IED in men and women, including emotion regulation and social information processing (SIP). Adult men and women ( N = 582), who completed a semistructured clinical interview for syndromal and personality disorders, were classified as healthy controls (HC; n = 118), psychiatric controls (PC; n = 146) or participants with an IED diagnosis ( n = 318). Participants also completed the life history of experienced aggression (LHEA) and life history of witnessed aggression (Lhwa) structured interview and self-report measures of emotion regulation and SIP. Men reported more EIV over the lifetime. In multiple logistic regression analysis, experiencing and witnessing aggression within the family and experiencing aggression outside the family were associated with lifetime IED diagnosis. We found that the relationship between EIV and IED was stronger in women than in men. Affective dysregulation mediated certain forms of EIV, and this relation was observed in both men and women. SIP biases did not mediate the relation between EIV and IED. EIV across the lifespan is a robust risk factor for recurrent, clinically significant aggressive behavior (i.e., IED). However, the relationship between EIV and IED appears to be stronger in women. Further, this relation appears partially mediated by affective dysregulation.
Organizational Readiness for Intimate Partner Violence Response among Supportive Housing Providers: A Capacity Assessment in Maryland
Authors: Kaur Arshdeep , Grace Karen Trister , Holliday Charvonne N. , Denhard Langan , Miller Janice , Decker Michele R.
Published: May 2021

Intimate partner violence (IPV) frequently leads to housing instability and homelessness among survivors. While the client populations of many housing support programs are likely to include IPV survivors who have unique safety needs, the organizational readiness of these housing providers to identify and support IPV survivors is not clear. This study assessed organizational readiness for IPV response among Rapid Re-Housing (RRH) and Transitional Housing (TH) providers in Maryland, whose client populations include women ( n = 32). We adapted the Physician Readiness to Manage Intimate Partner Violence Survey (PREMIS) to create the Housing provider Readiness to Manage IPV Survey (H-REMIS), inclusive of IPV-related perceptions, policies, staff training and capability, and resources. The 12-point H-REMIS demonstrated acceptable internal consistency reliability (Cronbach’s α = 0.748). Descriptive and comparative analyses domains by IPV-specific ( n = 4) and general ( n = 28) housing providers assessed readiness and identified areas for improvement. IPV-specific providers had higher mean organizational readiness for IPV response scores relative to non-IPV specific providers (11.3 and 7.5, respectively). High readiness areas included perceiving the importance of IPV and staff having adequate time, space, and comfort level to address IPV. Areas of low readiness included development and use of IPV response policies as well as staff training on IPV. This assessment documents concerning gaps in organizational readiness for IPV response among supportive housing providers, and pinpoints areas where training and capacity building can be most valuable. The process of improving readiness in the supportive housing sector must involve capacity building and a systems-level approach in order to ensure that all supportive housing providers are prepared to meet the needs of IPV survivors among their client population.
Clothing Consumption During the COVID-19 Pandemic: Evidence From Mining Tweets
Authors: Liu Chuanlan , Xia Sibei , Lang Chunmin
Published: May 2021

Understanding how consumers have shifted in clothing consumption in the midst of the global COVID-19 pandemic is critical for fashion clothing brands and businesses to identify what value means to consumers to locate growth opportunities. This exploratory study intends to provide a picture of consumers’ clothing consumption evolution while going through the pandemic crisis. We take a viewpoint that integrates the perspectives of life status changes and stress coping to examine consumers’ responses to clothing consumption during the COVID-19 global pandemic. A total of 68,511 relevant tweets were collected from January 1, 2020, through September 31, 2020. Sentiment and content analysis identified five themes which are revealed by 16 topics associated with clothing consumption over the phases of pre-lockdown, lockdown, and reopening. Pent-up demand for clothing products and changed clothing consumption habits were identified. Our findings provide evidence that consumption change is the fundamental mechanism of stress coping.