bluuebunny/crossref_metadata_2025 huggingface dataset:
Shared hotspot mutations in oncogenes position dogs as an unparalleled comparative model for precision therapeutics
Authors: Rodrigues Lucas , Watson Joshua , Feng Yuan , Lewis Benjamin , Harvey Garrett , Post Gerald , Megquier Kate , White Michelle E. , Lambert Lindsay , Miller Aubrey , Lopes Christina , Zhao Shaying
Published: July 2023

Naturally occurring canine cancers have remarkable similarities to their human counterparts. To better understand these similarities, we investigated 671 client-owned dogs from 96 breeds with 23 common tumor types, including those whose mutation profile are unknown (anal sac carcinoma and neuroendocrine carcinoma) or understudied (thyroid carcinoma, soft tissue sarcoma and hepatocellular carcinoma). We discovered mutations in 50 well-established oncogenes and tumor suppressors, and compared them to those reported in human cancers. As in human cancer, TP53 is the most commonly mutated gene, detected in 22.5% of canine tumors overall. Canine tumors share mutational hotspots with human tumors in oncogenes including PIK3CA, KRAS, NRAS, BRAF, KIT and EGFR. Hotspot mutations with significant association to tumor type include NRAS G61R and PIK3CA H1047R in hemangiosarcoma, ERBB2 V659E in pulmonary carcinoma, and BRAF V588E (equivalent of V600E in humans) in urothelial carcinoma. Our findings better position canines as a translational model of human cancer to investigate a wide spectrum of targeted therapies.
Unsteady mix convectional stagnation point flow of nanofluid over a movable electro-magnetohydrodynamics Riga plate numerical approach
Authors: Nasir Saleem , Berrouk Abdallah S. , Gul Taza , Zari Islam , Alghamdi Wajdi , Ali Ishtiaq
Published: July 2023

The flow at a time-independent separable stagnation point on a Riga plate under thermal radiation and electro-magnetohydrodynamic settings is examined in this research. Two distinct base fluids-H2O and C2H6O2 and TiO2 nanostructures develop the nanocomposites. The flow problem incorporates the equations of motion and energy along with a unique model for viscosity and thermal conductivity. Similarity components are then used to reduce these model problem calculations. The Runge Kutta (RK-4) function yields the simulation result, which is displayed in graphical and tabular form. For both involved base fluid theories, the nanofluids flow and thermal profiles relating to the relevant aspects are computed and analyzed. According to the findings of this research, the C2H6O2 model heat exchange rate is significantly higher than the H2O model. As the volume percentage of nanoparticles rises, the velocity field degrades while the temperature distribution improves. Moreover, for greater acceleration parameters, TiO2/ C2H6O2has the highest thermal coefficient whereas TiO2/ H2O has the highest skin friction coefficient. The key observation is that C2H6O2 base nanofluid has a little higher performance than H2O nanofluid.
Target of selective auditory attention can be robustly followed with MEG
Authors: Kurmanavičiūtė Dovilė , Kataja Hanna , Jas Mainak , Välilä Anne , Parkkonen Lauri
Published: July 2023

Selective auditory attention enables filtering of relevant acoustic information from irrelevant. Specific auditory responses, measurable by magneto- and electroencephalography (MEG/EEG), are known to be modulated by attention to the evoking stimuli. However, such attention effects have typically been studied in unnatural conditions (e.g. during dichotic listening of pure tones) and have been demonstrated mostly in averaged auditory evoked responses. To test how reliably we can detect the attention target from unaveraged brain responses, we recorded MEG data from 15 healthy subjects that were presented with two human speakers uttering continuously the words “Yes” and “No” in an interleaved manner. The subjects were asked to attend to one speaker. To investigate which temporal and spatial aspects of the responses carry the most information about the target of auditory attention, we performed spatially and temporally resolved classification of the unaveraged MEG responses using a support vector machine. Sensor-level decoding of the responses to attended vs. unattended words resulted in a mean accuracy of $$79\% \pm 2 \%$$

79
%
±
2
%

(N = 14) for both stimulus words. The discriminating information was mostly available 200–400 ms after the stimulus onset. Spatially-resolved source-level decoding indicated that the most informative sources were in the auditory cortices, in both the left and right hemisphere. Our result corroborates attention modulation of auditory evoked responses and shows that such modulations are detectable in unaveraged MEG responses at high accuracy, which could be exploited e.g. in an intuitive brain–computer interface.
Latent sub-structural resilience mechanisms in temporal human mobility networks during urban flooding
Authors: Rajput Akhil Anil , Mostafavi Ali
Published: July 2023

In studying resilience in temporal human networks, relying solely on global network measures would be inadequate; latent sub-structural network mechanisms need to be examined to determine the extent of impact and recovery of these networks during perturbations, such as urban flooding. In this study, we utilize high-resolution aggregated location-based data to construct temporal human mobility networks in Houston in the context of the 2017 Hurricane Harvey. We examine motif distribution, motif persistence, temporal stability, and motif attributes to reveal latent sub-structural mechanisms related to the resilience of human mobility networks during disaster-induced perturbations. The results show that urban flood impacts persist in human mobility networks at the sub-structure level for several weeks. The impact extent and recovery duration are heterogeneous across different network types. Also, while perturbation impacts persist at the sub-structure level, global topological network properties indicate that the network has recovered. The findings highlight the importance of examining the microstructures and their dynamic processes and attributes in understanding the resilience of temporal human mobility networks (and other temporal networks). The findings can also provide disaster managers, public officials, and transportation planners with insights to better evaluate impacts and monitor recovery in affected communities.
Interventions to reduce burnout among clinical nurses: systematic review and meta-analysis
Authors: Lee Miran , Cha Chiyoung
Published: July 2023

Sporadic evidence exists for burnout interventions in terms of types, dosage, duration, and assessment of burnout among clinical nurses. This study aimed to evaluate burnout interventions for clinical nurses. Seven English databases and two Korean databases were searched to retrieve intervention studies on burnout and its dimensions between 2011 and 2020.check Thirty articles were included in the systematic review, 24 of them for meta-analysis. Face-to-face mindfulness group intervention was the most common intervention approach. When burnout was measured as a single concept, interventions were found to alleviate burnout when measured by the ProQoL (n = 8, standardized mean difference [SMD] = − 0.654, confidence interval [CI] =  − 1.584, 0.277, p < 0.01, I2 = 94.8%) and the MBI (n = 5, SMD = − 0.707, CI = − 1.829, 0.414, p < 0.01, I2 = 87.5%). The meta-analysis of 11 articles that viewed burnout as three dimensions revealed that interventions could reduce emotional exhaustion (SMD = − 0.752, CI = − 1.044, − 0.460, p < 0.01, I2 = 68.3%) and depersonalization (SMD = − 0.822, CI = − 1.088, − 0.557, p < 0.01, I2 = 60.0%) but could not improve low personal accomplishment. Clinical nurses' burnout can be alleviated through interventions. Evidence supported reducing emotional exhaustion and depersonalization but did not support low personal accomplishment.
Coulomb engineering of two-dimensional Mott materials
Authors: van Loon Erik G. C. P. , Schüler Malte , Springer Daniel , Sangiovanni Giorgio , Tomczak Jan M. , Wehling Tim O.
Published: July 2023

Two-dimensional materials can be strongly influenced by their surroundings. A dielectric environment screens and reduces the Coulomb interaction between electrons in the two-dimensional material. Since in Mott materials the Coulomb interaction is responsible for the insulating state, manipulating the dielectric screening provides direct control over Mottness. Our many-body calculations reveal the spectroscopic fingerprints of such Coulomb engineering: we demonstrate eV-scale changes to the position of the Hubbard bands and show a Coulomb engineered insulator-to-metal transition. Based on our proof-of-principle calculations, we discuss the (feasible) conditions under which our scenario of Coulomb engineering of Mott materials can be realized experimentally.
Carbon nitride based materials: more than just a support for single-atom catalysis
Authors: Rocha Guilherme F. S. R , da Silva Marcos A. R. , Rogolino Andrea , Diab Gabriel A. A. , Noleto Luis F. G. , Antonietti Markus , Teixeira Ivo F.
Published: July 2023

Carbon nitride single-atom based catalysts: supporting the transition from the fossil past to the green future.
The triacylglycerol structure and composition of a human milk fat substitute affect the absorption of fatty acids and calcium, lipid metabolism and bile acid metabolism in newly-weaned Sprague-Dawley rats
Authors: Zhu Lin , Fang Shuaizhen , Liu Wenwen , Zhang Hong , Zhang Yaqiong , Xie Zhuohong , Yang Puyu , Wan Jianchun , Gao Boyan , (Lucy) Yu Liangli
Published: July 2023

In this study, the effect of sn-2 palmitic triacylglycerols (sn-2 palmitic TAGs) and the ratio between the two major sn-2 palmitic TAGs (OPL to OPO ratio) in a human milk fat substitute (HMFS) on growth, fatty acid and calcium absorptions, and lipid and bile acid metabolic alterations was investigated in Sprague-Dawley rats.
Stereoselective syntheses of 2-methyl-1,3-diol acetalsviaRe-catalyzed [1,3]-allylic alcohol transposition
Authors: Liu Jiaming , Chen Ming
Published: July 2023

Rhenium-catalyzed stereoselective transposition of allylic alcohols is reported.
Controllable mitochondrial aggregation and fusion by a programmable DNA binder
Authors: Zhu Longyi , Shen Yiting , Deng Shengyuan , Wan Ying , Luo Jun , Su Yan , You Mingxu , Fan Chunhai , Ren Kewei
Published: July 2023

DNA nano-binder has been designed as the artificial controller for the aggregation and fusion of mitochondria in living cells.
Augmentation of FTIR spectral datasets using Wasserstein generative adversarial networks for cancer liquid biopsies
Authors: McHardy Rose G. , Antoniou Georgios , Conn Justin J. A. , Baker Matthew J. , Palmer David S.
Published: July 2023

Data augmentation using simulated FTIR spectra produced by a Wasserstein generative adversarial network (WGAN) significantly improves deep learning based spectroscopic liquid biopsies for detecting pancreatic and colorectal cancer.
MoS2 nanosheets grown on bowl-shaped hollow carbon spheres as an efficient electrochemical sensor for ultrasensitive determination of nephrotoxic aristolochic acids in Chinese traditional herbs
Authors: Zhou Menglin , Tang Tingfan , Deng Xiujun , Li Qian , Zuo Zesen , Hu Guangzhi
Published: July 2023

Molybdenum disulfide decorated bowl-shaped hollow carbon is used to fabricate an ultra-sensitive electrochemical sensor for the accurate determination of aristolochic acids.
Stimuli-responsive nanozymes for biomedical applications
Authors: Zhang Mengli , Tong Weijun
Published: July 2023

Stimuli-responsive nanozymes with stimuli-switchable catalytic activities or stimuli-responsive release behaviors have unique applications in the fields of tumor therapy, antibacterial therapy, biosensing and anti-inflammatory therapy.
On the nucleation and fast reaction kinetics of 2D polymerisation with a 2-in-1 monomer
Authors: Herrmann Niklas , Martin Cristina , Eyley Samuel , Li Yusen , Bilbao Nerea , Rubio-Giménez Víctor , Van der Auweraer Mark , Thielemans Wim , Chen Long , Mali Kunal S. , De Feyter Steven
Published: July 2023

We report on the fast reaction kinetics of an imine based 2D polymer formed from a single monomer carrying both aldehyde and amine groups.
A sumanene-containing magnetic nanoadsorbent for the removal of caesium salts from aqueous solutions
Authors: Kasprzak Artur , Matczuk Magdalena , Sakurai Hidehiro
Published: July 2023

The sumanene-containing, magnetic nanomaterial was synthesized and applied as an effective, selective, and reusable nanoadsorbent for caesium removal.
Construction of Cu2+-doped MnCO3 micro-rhombohedrons and micro-olives as promising anode materials for high performance lithium-ion batteries
Authors: Dong Fangyuan , Dong Xuelu , Cui Chuansheng , Zeng Suyuan , Fu Chonggang , Wang Lei
Published: July 2023

As the anode material for lithium-ion battery, Cu2+-doped MnCO3 micro-olives are prepared by a solvothermal method, deliver a high capacity and good cycle stability. A reversible capacity of 823.5 mA h g−1 after 1000 cycles at 0.5 A g−1 is achieved.
Electric-field frictional effects in confined zwitterionic molecules
Authors: Gianetti Melisa M. , Guerra Roberto , Vanossi Andrea , Urbakh Michael , Manini Nicola
Published: July 2023

We theoretically explore the effect of a transverse electric field on the frictional response of a bi-layer of packed zwitterionic molecules, leading, via their dipole-moment reorientation, either to stick-slip or smooth sliding dynamics.
Magnetoresistance originated from the Au/S interface in Au/1,6-hexanedithiol/Au single-molecule junctions at room temperature
Authors: Andika Rachmat , Yamada Ryo , Tada Hirokazu
Published: July 2023

We report a magnetic response of Au/1,6-hexanedithiol/Au single-molecule junctions at room temperature using a mechanically controllable break junction method.
The attenuating ability of deep eutectic solvents towards the carboxylated multiwalled carbon nanotubes induced denatured β-lactoglobulin structure
Authors: Yadav Niketa , Mor Sanjay , Venkatesu Pannuru
Published: July 2023

The DES system enhances the stability of the protein by reducing the perturbation caused by CA-MWCNTs. The results pave a new direction for the development of eco-friendly protein-protective eco-friendly solvent.
Stability and decomposition pathways of the NiOOH OER active phase of NiOx electrocatalysts at open circuit potential traced by ex situ and in situ spectroscopies
Authors: Gallenberger Julia , Moreno Fernández Harol , Alkemper Achim , Li Mohan , Tian Chuanmu , Kaiser Bernhard , Hofmann Jan Philipp
Published: July 2023

The OER active phase of NiOx electrocatalysts, i.e. NiOOH, decomposes outside operating potential to Ni(OH)2 requiring operando characterization approaches.
Controlled synthesis of ACo2O4 (A = Fe, Cu, Zn, Ni) as an environmentally friendly electrocatalyst for urea electrolysis
Authors: Li Ping , Wang Yanhong , Du Xiaoqiang , Zhang Xiaoshuang
Published: July 2023

In a cell composed of CuCo2O4//CuCo2O4, a current density of 10 mA cm−2 can be achieved by providing a potential of only 1.509 V.
Single Cu–N4sites enable atomic Fe clusters with high-performance oxygen reduction reactions
Authors: Wu Shuwen , Jiang Shang , Liu Shao-Qing , Tan Xuehai , Chen Ning , Luo Jing-Li , Mushrif Samir H. , Cadien Ken , Li Zhi
Published: July 2023

Atomic Fe clusters functionalized by Cu–N4sites with enhanced oxygen reduction reactions (ORRs) in alkaline and acidic media.
Efficient treatment of landfill leachate membrane bioreactor effluent through sequential coagulation–flocculation and electrooxidation
Authors: Bayat Muhammed Enes , Bilgin Oyku Nur , Varank Gamze , Yazici Guvenc Senem , Can-Güven Emine
Published: July 2023

This study investigated the performance of sequential chemical coagulation–electrooxidation (EO) processes in treating leachate membrane bioreactor (MBR) effluent.
Novel metallated imidazole phthalocyanines: synthesis, ultrafast excited-state carrier dynamics and multiphoton absorption properties
Authors: Ahmed Md Soif , Srivishnu Kalavala Shivaprakash , Biswas Chinmoy , Banerjee Dipanjan , Chetti Prabhakar , Soma Venugopal Rao , Giribabu Lingamallu , Raavi Sai Santosh Kumar
Published: July 2023

Herein we report a comprehensive investigation of ultrafast photophysics and nonlinear optical properties of novel metallated imidazole phthalocyanines.
Hierarchical porous carbon foam embedded with readily accessible atomic iron sites for efficient electrochemical nitrite sensing
Authors: Miao Runyang , Hu Hongyin , Zhang Bingyan , Zhu Han , Du Mingliang , Lu Shuanglong
Published: July 2023

A hierarchical porous carbon foam embedded with atomic iron sites is facilely synthesized and works as an efficient electrochemical nitrite sensor.
Highly active higher coordinated copper(i)–N-heterocyclic chalcogenone catalysed click chemistry
Authors: Mandal Suman , Harijan Dinesh , Muduli Gopendra , Subramaniyam Kalaivanan , Rengan Aravind Kumar , Prabusankar Ganesan
Published: July 2023

The tri-coordinated and tetra-coordinated copper(i) N-heterocyclic chalcogenone catalyzed [3+2] cycloaddition reaction has been reported to understand the role of ancillary ligands and the coordination environment of the catalyst.
Low-frequency noise in nanowires
Authors: Fleetwood Daniel M.
Published: July 2023

This paper reviews 40 years of research on low-frequency noise and random-telegraph noise in metallic and semiconducting nanowires.
Control over product formation and thermodynamic stability of thiolate-protected gold nanoclusters through tuning of surface protecting ligands
Authors: Maman Manju P. , Nida Nahan Eyyakkandy , Suresh Greeshma , Das Arunendu , Nair Akhil S. , Pathak Biswarup , Mandal Sukhendu
Published: July 2023

Surface-protecting ligands can regulate the structure of a cluster's core either through electronic or steric effects.
Microwave-assisted DABCO-promoted regioselective [3 + 3] tandem cyclization: synthesis of pyrrolo[3,4-b]pyridine-4-ones from trifluoromethyl-alkynyl esters and α-aminomaleimide
Authors: Yang Qi , Huang Shuntao , Yin Lu , Wang Zhuoyu , Chen Xuebing , Huang Chao
Published: July 2023

A microwave-assisted DABCO-promoted regioselective [3 + 3] tandem cyclization reaction featuring operational simplicity, metal-free reaction conditions, and short reaction times is reported.
Preparation of inorganic-framework molecularly imprinted TiO2/SiO2 nanofibers by one-step electrospinning and their highly selective photodegradation
Authors: Li Jingyao , Song Yanhua , Wang Fangke , Zhang Xiaozhen , Zhu Haiyuan , Zou Haifeng
Published: July 2023

The TiO2/SiO2 hybrid fibers were successfully prepared by a simple electrospinning method and modified by direct molecular imprinting. The as-prepared samples exhibit excellent selectivity and photocatalytic performance.
Advances in the application of manganese dioxide and its composites for theranostics
Authors: Hao Jiaqi , Zhao Yu , Ma Yiqi , Liu Beibei , Luo Yonglan , Alfaifi Sulaiman , Sun Xuping , Wu Min
Published: July 2023

This review summarizes recent advances in the application of manganese dioxide and its composites for theranostics.
Universal synthesis of rare earth-doped FeP nanorod arrays for the hydrogen evolution reaction
Authors: Chen Minnan , Lin Zijing , Ren Yi , Wang Xuan , Li Meng , Sun Dongmei , Tang Yawen , Fu Gengtao
Published: July 2023

A universal plasma-assisted strategy is proposed for the fabrication of rare earth-doped FeP as a kind of potential electrocatalyst for the hydrogen evolution reaction.
Electrochemical and power conversion performance of different counter electrode materials for flexible dye-sensitized solar cells
Authors: Pervaiz Hina , Shahzad Nadia , Jamil Qasim , Shahzad Muhammad Imran
Published: July 2023

Carbon dots and copper indium sulfide are promising photovoltaic materials, which have so far been fabricated mainly by chemical deposition methods.
Study on the effect of fluorinated solvent electrolyte on the active material and cycle performance of a commercial 21700-type battery
Authors: Liu Wenbin , Li Xinyu , Zhao Yingcai , Wu Lan , Hong Shu
Published: July 2023

Different electrolyte schemes were studied on the traditional commercial 21700-type battery.
Mechanism landscape in pyrylium induced organic afterglow systems
Authors: Wang Guangming , Chen Xuefeng , Li Xun , Zeng Ying , Zhang Kaka
Published: July 2023

The afterglow mechanism varies from thermally activated delayed fluorescence through room temperature phosphorescence to organic long persistent luminescence by changing monomer types.
Machine-learning-aided multiplexed nanoplasmonic biosensor for COVID-19 population immunity profiling
Authors: Beisenova Aidana , Adi Wihan , Bashar S. Janna , Velmurugan Monniiesh , Germanson Kenzie B. , Shelef Miriam A. , Yesilkoy Filiz
Published: July 2023

Vaccination and infection rates against variants of COVID-19 in Dane County, WI were determined from low-volume human sera/plasma samples with machine-learning aided nanoplasmonic biosensor. The results agree with the official epidemiological data.
Zinc bromide: a general mediator for the ionothermal synthesis of microporous polymers via cyclotrimerization reactions
Authors: Kim Jaehwan , Le Minh H. , Spicer Makayla C. , Moisanu Casandra M. , Pugh Suzi M. , Milner Phillip J.
Published: July 2023

Porous organic polymers are prepared via cyclotrimerization reactions mediated by zinc bromide under solvent-free conditions.
Low-frequency AC-photocatalysis coupling for high-efficiency removal of organic pollutants from water based on the self-powered triboelectric nanogenerator
Authors: Hao Xinyu , Huang Tao , Li Ming , Pan Yating , Liao Lei , Zhang Kaiyou , Qin Aimiao
Published: July 2023

The integrated low-frequency AC photoelectrocatalytic system based on RF-TENG can simultaneously complete four process steps of power generation, catalytic degradation, aeration and stirring, while improving the degradation efficiency.
Understanding dehydration of Prussian white: from material to aqueous processed composite electrodes for sodium-ion battery application
Authors: Maddar F. M. , Walker D. , Chamberlain T. W. , Compton J. , Menon A. S. , Copley M. , Hasa I.
Published: July 2023

Understanding dehydration of Prussian white systems to enable processability of water-based electrodes for sustainable and high capacity sodium-ion batteries.
Asymmetric anthracene hosts decorated with naphthobenzofurocarbazole for highly efficient deep-blue organic light-emitting diodes and low-efficiency roll-off
Authors: Jeong Yeonju , Hwang Kyo Min , Lee Jae Hee , Kwon Min Jeong , Kim Taekyung , Hong Wan Pyo
Published: July 2023

OLED devices utilizing naphthobenzofurocarbazole emitters exhibited a maximum external quantum efficiency of 7.0%, a remarkably low-efficiency roll-off of 4.8% was achieved at 1000 cd m−2, and the HLCT mechanism was identified.
Enhanced plastic economy: a perspective and a call for international action
Authors: Tang Kuok Ho Daniel
Published: July 2023

The current plastic circular economy lacks a uniform framework. It overfocuses on recycling, reuse and energy recovery. An enhanced plastic economy drives innovation and concerted effort in reducing plastic pollution and waste management.
Detection and location of microaneurysms in fundus images based on improved YOLOv4 with IFCM
Authors: Gao Weiwei , Fan Bo , Fang Yu , Shan Mingtao , Song Nan
Published: July 2023

Diabetic retinopathy (DR) is one of the leading causes of blindness for people suffering from diabetes. Microaneurysm (MA) is the initial symptom of DR. MA is a lesion based disease which starts as small red spots on the retina and increases in size as the DR progresses which finally leads to blindness. So eliminating the lesion can effectively prevent DR at an early stage. However, due to complex retinal structure, different brightness and contrast of fundus images with effects of factors such as different patients, environment changes, and difference in acquisition equipment, it is difficult for existing detection algorithms to achieve accurate results of MA detection and location. Therefore, the detection algorithm of improved YOLOv4 (YOLOv4‐Pro) was proposed. First, an improved Fuzzy C‐Means (IFCM) clustering algorithm was proposed to optimize anchor parameters of target samples to improve matching results between anchors and feature graphs. In order to control noise and improve efficiency, a median filtering method was employed to update the criterion function of the original FCM algorithm, and a K‐means algorithm was employed to initialize clustering. Second, a SENet attention module was added in the backbone of YOLOv4 to enhance key information and suppress background, improving the confidence of MA effectively. Finally, the spatial pyramid pooling (SPP) module was added to the neck to enhance the acceptance domain of the output characteristics of the backbone network, and profits separating of important context information. The improved YOLOv4 with IFCM was verified on the Kaggle DR dataset and compared with other methods. Experimental results show that optimizing the prior frame with the IFCM algorithm can make it suitable to frame the Kaggle DR dataset, which improves the detection accuracy of the network by nearly 5%, and provides a nice performance on detection and location of MA in fundus images. This would help ophthalmologists finding the exact location of MA on retina, thereby simplifying the process and eliminating any manual intervention.
Density asymmetry and wind velocities in the orbital plane of the symbiotic binary EG Andromedae
Authors: Shagatova N. , Skopal A. , Kundra E. , Komžík R. , Shugarov S. Yu. , Pribulla T. , Krushevska V.
Published: July 2023

Context.Non-dusty late-type giants without a corona and large-scale pulsations represent objects that do not fulfil the conditions under which standard mass-loss mechanisms can be applied efficiently. Despite the progress during the past decades, the driving mechanism of their winds is still unknown.

Aims.One of the crucial constraints of aspiring wind-driving theories can be provided by the measured velocity and density fields of outflowing matter. The main goal of this work is to match the radial velocities of absorbing matter with a depth in the red giant (RG) atmosphere in the S-type symbiotic star EG And.

Methods.We measured fluxes and radial velocities of ten Fe I absorption lines from spectroscopic observations with a resolution of ≈30 000. At selected orbital phases, we modelled their broadened profiles, including all significant broadening mechanisms.

Results.The selected Fe I absorption lines at 5151–6469 Å originate at a radial distance ≈1.03 RG radii from its centre. The corresponding radial velocity is typically ≈1 km s−1, which represents a few percent of the terminal velocity of the RG wind. The high scatter of the radial velocities of several km s−1in the narrow layer of the stellar atmosphere points to the complex nature of the near-surface wind mass flow. The average rotational velocity of 11 km s−1implies that the rotation of the donor star can contribute to observed focusing the wind towards the orbital plane. The orbital variability of the absorbed flux indicates the highest column densities of the wind in the area between the binary components, even though the absorbing neutral material is geometrically more extended from the opposite side of the giant. This wind density asymmetry in the orbital plane region can be ascribed to gravitational focusing by the white dwarf companion.

Conclusions.Our results suggest that both gravitational and rotational focusing contribute to the observed enhancement of the RG wind towards the orbital plane, which makes mass transfer by the stellar wind highly efficient.
Le Programme 13-Novembre entre mémoire individuelle et mémoire collective
Authors: Eustache Francis , Peschanski Denis
Published: July 2023

Cet article a pour objectif de présenter l’évolution des travaux scientifiques sur la mémoire humaine de la fin du 19e siècle à aujourd’hui. Les travaux de psychologie expérimentale et de neuropsychologie ont d’abord dominé la scène scientifique. Des recherches en sciences humaines et sociales se sont mises en place dans l’entre-deux-guerres, mais sans réelle interaction avec celles menées en psychologie et en neurosciences. Cette clôture disciplinaire a persisté jusqu’à la fin du 20e siècle. Un véritable tournant social s’est opéré depuis les années 2000 avec comme volonté d’étudier et de comprendre les interactions entre mémoires individuelles et mémoires collectives. Dans cet article, les auteurs plaident pour l’émergence de « sciences de la mémoire » fondées sur la dialectique et la transdisciplinarité. Ils s’appuient sur leProgramme 13-Novembre, emblématique de cette évolution. Sa genèse, son architecture d’ensemble et plusieurs de ses composantes sont présentées ici ainsi que quelques résultats déjà publiés. Outre leur portée théorique, ces travaux rendent possibles de nombreuses applications, en particulier dans la compréhension et la prise en charge de différentes pathologies, le trouble de stress post-traumatique étant la plus démonstrative à cet égard.
Mémoires des attentats terroristes du 13-Novembre 2015 : ce que peut nous apprendre l’analyse de discours
Authors: Peschanski Denis , Pincemin Bénédicte , Heiden Serge , Lacoste Charlotte
Published: July 2023

Le Programme 13-Novembre vise à analyser la mémoire individuelle et collective des attentats terroristes du 13 novembre 2015. Au cœur se trouve l’Étude 1000 qui doit recueillir, à 4 reprises en 10 ans, les témoignages des mêmes 1000 personnes dans des entretiens audiovisuels. Disposant des transcriptions, nous choisissons ici de montrer l’importance de l’analyse de discours en rappelant ses fondements théoriques, de présenter l’un des outils permettant cette analyse statistique, l’Analyse Factorielle des Correspondances, et de l’utiliser pour analyser le sous-corpus des entretiens réalisés à distance des événements parisiens, auprès de 76 habitants de la région de Metz. Croisant ces volontaires avec les mots qu’ils utilisent, on constate que deux variables ressortent clairement qui opposent les vocabulaires, la variable du genre et la variable de l’âge.
Mémoire et traumatisme : de la biologie aux sciences sociales
Authors: Eustache Francis , Guillery Bérengère , Peschanski Denis
Published: July 2023

Cet article est une brève Introduction à une série d’articles issus de la Journée Claude Bernard, organisée à l’Académie Nationale de Médecine le 24 novembre 2021. Cette Journée, dont le thème était « Mémoire et traumatisme », avait pour originalité de présenter des travaux provenant de disciplines différentes allant des sciences biologiques aux sciences humaines et sociales. Plusieurs publications s’appuient sur leProgramme 13-Novembre, qui envisage les conséquences des attentats du 13 novembre 2015 sur la construction des mémoires individuelles et collectives de cet événement dramatique.
Rupturen großer Sehnen – Aspekte der Begutachtung
Authors: Dresing Klaus , Schiltenwolf Marcus
Published: July 2023

Sehnen übertragen die Muskelkraft auf den Knochen. Die Sehnen an sich, der Muskel-Sehnen-Übergang und die Knochenansätze sind ständig mechanischen Belastungen ausgesetzt. Sehnen reagieren funktional auf mechanische Kräfte, indem sie ihren Stoffwechsel sowie ihre strukturellen und mechanischen Eigenschaften verändern. Im Laufe des Alters und unter Belastungen können Sehnen altern, durch mechanische Belastung aufgebraucht werden. Schadensanlage und Vorschaden sollten erfasst werden. Bei der Begutachtung muss unterschieden werden, ob es sich um ein adäquates Trauma handelt, dass eine Sehne zerreißen kann, oder um eine Alltagsbelastung, die Kausalität muss geklärt werden.
Aufbereitung von Trachealkanülen im außerklinischen Bereich
Authors: Ziech Patrick , Schwarz Stefanie
Published: July 2023

Aufgrund medizinischer und technischer Fortschritte ließ sich die Prognose der Patienten mit chronischer Atemschwäche in den letzten Jahren stetig optimieren. Die beatmeten Patienten werden nach der Klinikbehandlung entweder in einem spezialisierten Pflegeheim, im eigenen häuslichen Umfeld oder in Wohngemeinschaften pflegerisch und medizinisch betreut 1. Welche Herausforderungen hierbei zu meistern sind, lesen Sie in diesem Beitrag.
Large serrated polyps indicate a greater risk of advanced metachronous colorectal neoplasia than high-grade adenomas
Authors: Medawar Edgard , Djinbachian Roupen , Taghiakbari Mahsa , Khoury Tommy , Zoughlami Amine , Zarandi-Nowroozi Melissa , Safih Widad , von Renteln Daniel
Published: July 2023

Background and study aims The risk of developing total metachronous advanced neoplasia (TMAN) in patients with index serrated lesions (SL) or adenoma with high-grade dysplasia (HGD) is unknown. We evaluated this risk in patients with either HGD, SL < 10 mm or SL ≥ 10 mm at index colonoscopy, who underwent surveillance colonoscopies.

Patients and methods This retrospective cohort study evaluated all consecutive patients (n = 2477) diagnosed between 2010 and 2019 with colorectal HGD, SLs < 10 mm or SLs ≥ 10 mm. We excluded patients aged < 45 or > 75 years or those who had inflammatory bowel disease, hereditary colorectal cancer (CRC) syndromes, previous or synchronous CRC, or no follow-up colonoscopy. Descriptive variables were compared using analysis of variance or Pearson chi-squared tests. Multivariate Cox regressions were used to compare the risk of TMAN between the HGD, SL < 10 mm and SL ≥ 10 mm groups.

Results Overall, 585 patients (mean age 63 years; 55% male; mean follow-up 3.67 years) were included (226 with SLs < 10 mm, 204 with SLs ≥ 10 mm, 155 with HGD). Compared with SLs < 10 mm, patients with HGD did not have a significantly different rate of TMAN (HR=0.75 [0.39–1.44]) and patients with SLs ≥ 10 mm had a higher rate of TMAN (HR=2.08 [1.38–3.15]). Compared with HGD, patients with SLs ≥ 10 mm had a higher rate of TMAN (HR=1.87 [1.04–3.36]).

Conclusions The risk for TMAN was higher for patients with SLs ≥ 10 mm than with HGD or SLs < 10 mm. This risk should be considered when planning surveillance intervals for patients diagnosed with large SLs.
In the Hands of Hypnos: Associations between Sleep, Cognitive Performance and Financial Capacity in aMCI and Mild AD
Authors: Giannouli Vaitsa , Tsolaki Magda
Published: July 2023

Objective The aim of this monocentric observational study is to assess whether sleep disorders can predict financial capacity in single-and multiple-domain aMCI (amnestic Mild Cognitive Impairment), mild Alzheimer's Disease (AD), and healthy controls.

Methods Older participants from Northern Greece were examined with several neuropsychological tests, including Mini-Mental State Examination (MMSE), Geriatric Depression Scale (GDS-15), and the Legal Capacity for Property Law Transactions Assessment Scale (LCPLTAS). Sleep duration and quality were based on caregiver/family members' reports in the Sleep Disorders Inventory (SDI).

Results These preliminary findings coming from 147 participants indicate for the first time that apart from MMSE, complex cognitive functions, such as financial capacity may be also directly linked to the frequency of sleep-disturbed behaviours as indicated by SDI frequency questions, both in aMCI and mild AD.

Discussion An urgency for further investigation of the neglected sleep factor should be added in financial capacity assessment protocols.
Is it Mandatory to do a 24 hour ABPM in all Patients with Moderate to Severe Obstructive Sleep Apnoea?
Authors: Osuna Edgar D. , Zamora Adrián C. , Buitrago Andrés F. , Salazar Jaime F. , Rosales Santiago A. , Galeano Camila , Guzman-Prado Yuli , Ferreira-Atuesta Carolina
Published: July 2023

Background Obstructive sleep apnoea (OSA) has been described as a risk factor for arterial hypertension (HT). One of the proposed mechanisms linking these conditions is non dipping (ND) pattern in nocturnal blood pressure, however evidence is variable and based on specific populations with underlying conditions. Data for OSA and ND in subjects residing at high altitude are currently unavailable.

Objective Identify the prevalence and association of moderate to severe OSA with HT and ND pattern in hypertensive and non-hypertensive otherwise healthy middle-aged individuals in residing at high altitude (Bogotá:2640 mt)

Methods Adult individuals with diagnosis of moderate to severe OSA underwent 24 hour- ambulatory blood pressure monitoring (ABPM) between 2015 and 2017. Univariable and multivariable logistic regression analysis were performed to identify predictors of HT and ND pattern.

Results Ninety-three (93) individuals (male 62.4% and median age 55) were included in the final analysis. Overall, 30.1% showed a ND pattern in ABPM and 14.9% had diurnal and nocturnal hypertension. Severe OSA (higher apnea-hiponea index [AHI]) was associated with HT (p = 0.006), but not with ND patterns (p = 0.54) in multivariable regression. Smoking status and lowest oxygen saturation during respiratory events where independently associated with ND pattern (p = 0.04), whereas age (p = 0.001) was associated with HT.

Conclusions In our sample, one in three individuals with moderate to severe OSA have non dipping patterns suggesting lack of straight association between OSA and ND. Older individuals who have higher AHI are more likely to have HT, and those who smoke have a higher risk of ND. These findings add aditional information to the multiple mechanisms involved in the relationship between OSA and ND pattern, and questions the routine use of 24-hour ABPM, particullary in our region, with limited resources and healthcare acces. However, further work with more robust methodology is needed to draw conclusions.
Sleep Assessment in Competitive Athletes: Development and Validation of French Versions of the Athens Insomnia Scale and the Athlete Sleep Behavior Questionnaire
Authors: Baize Diane , Meriaux-Scoffier Stéphanie , Chrétien Aurélia , Hayotte Meggy , Piponnier Enzo , d'Arripe-Longueville Fabienne
Published: July 2023

Objective The purpose of this study was to develop and validate French versions of two questionnaires assessing competitive athletes' sleep: the Athens Insomnia Scale (AIS-FR) and the Athlete Sleep Behavior Questionnaire (ASBQ-FR).

Methods Four complementary studies were carried out, with a total sample of 296 French competitive athletes from different sports and expertise levels. The studies aimed to develop preliminary versions of the AIS-FR and the ASBQ-FR (study 1), and then to examine their respective dimensionality and reliability (study 2), temporal stability (study 3), and concurrent validity (study 4). The dimensionality was established using confirmatory factor analysis. Similar and correlated psychological factor scales were used to examine the concurrent validity (the Insomnia Severity Index, the Pittsburgh Sleep Quality Index, the State-Trait Anxiety Inventory and the Positive and Negative Affect Schedule).

Results The AIS-FR consists of eight items with two subfactors: nocturnal symptoms and diurnal symptoms, assessed by a uniformized 4-point Likert-type scale. The ASBQ-FR is composed of 15 items with three subfactors, which differs from the original English version: behaviors affecting sleep, behaviors related to anxiety, and sleep disturbances. Due to the Covid context and curfews, three items of the original scale were excluded from the statistical analyses because non-applicable. Both scales presented satisfactory psychometric properties.

Discussion The AIS-FR and ASBQ-FR appear to be valid and reliable tools that can be used with competitive athletes for everyday training and research purposes. An ASBQ-FR version that includes the three excluded items should undergo validation testing once pandemic restrictions are eased.
Comparisons of Sleep, Demographics, and Health-Related Variables in Older Long and Average Duration Sleepers
Authors: Imran Patel Salma , R. Erwin Michael , Olmstead Richard , Jean-Louis Girardin , Parthasarathy Sairam , D. Youngstedt Shawn
Published: July 2023

Introduction Long sleep duration is associated with many health risks, particularly in older adults, but little is known about other characteristics associated with long sleep duration.

Methods Across 5 sites, adults aged 60-80 years who reported sleeping 8-9 h (“long sleepers”, n = 95) or 6-7.25 h (“average sleepers”, n = 103) were assessed for two weeks using actigraphy and sleep diary. Demographic and clinical characteristics, objective sleep apnea screening, self-reported sleep outcomes, and markers of inflammation and glucose regulation were measured.

Results Compared to average sleepers, long sleepers had a greater likelihood of being White and unemployed and/or retired. Long sleepers also reported longer time in bed, total sleep time and wake after sleep onset by sleep diary and by actigraphy. Other measures including medical co-morbidity, apnea/hypopnea index, sleep related outcomes such as sleepiness, fatigue, depressed mood, or markers of inflammation and glucose metabolism did not differ between long and average sleepers.

Conclusion Older adults with long sleep duration were more likely to be White, report unemployment and retirement suggesting the social factors or related sleep opportunity contributed to long sleep duration in the sample. Despite known health risks of long sleep duration, neither co-morbidity nor markers of inflammation or metabolism differed in older adults with long sleep duration compared with those with average sleep duration.
Automatic-Scoring Actigraph Compares Favourably to a Manually-Scored Actigraph for Sleep Measurement in Healthy Adults
Authors: Edgar David T. , Beaven C. Martyn , D. Gill Nicholas , L. Zaslona Jennifer , W. Driller Matthew
Published: July 2023

Introduction Actigraphy has been used widely in sleep research due to its non-invasive, cost-effective ability to monitor sleep. Traditionally, manually-scored actigraphy has been deemed the most appropriate in the research setting; however, technological advances have seen the emergence of automatic-scoring wearable devices and software.

Methods A total of 60-nights of sleep data from 20-healthy adult participants (10 male, 10 female, age: 26 ± 10 years) were collected while wearing two devices concomitantly. The objective was to compare an automatic-scoring device (Fatigue Science Readiband™ [AUTO]) and a manually-scored device (Micro Motionlogger® [MAN]) based on the Cole-Kripke method. Manual-scoring involved trained technicians scoring all 60-nights of sleep data. Sleep indices including total sleep time (TST), total time in bed (TIB), sleep onset latency (SOL), sleep efficiency (SE), wake after sleep onset (WASO), wake episodes per night (WE), sleep onset time (SOT) and wake time (WT) were assessed between the two devices using mean differences, 95% levels of agreement, Pearson-correlation coefficients (r), and typical error of measurement (TEM) analysis.

Results There were no significant differences between devices for any of the measured sleep variables (p ≥0.05). All sleep indices resulted in very-strong correlations (all r ≥0.84) between devices. A mean difference between devices of <1 minutes for TST was associated with a TEM of 15.5 minute (95% CI =12.3 to 17.7 minutes).

Conclusion Given there were no significant differences between devices in the current study, automatic-scoring actigraphy devices may provide a more practical and cost-effective alternative to manually-scored actigraphy in healthy populations.
Bibliometric analysis of Asian ‘language and linguistics’ research: A case of 13 countries
Authors: Lee Danielle
Published: July 2023

The foci of voluminous bibliometric studies on ‘language and linguistics’ research are limited to specific sub-topics with little regional context. Given the paucity of relevant literature, we are relatively uninformed about the regional trends of ‘language and linguistics’ research. This paper aims to analyze research developments in the field of ‘language and linguistics’ in 13 Asian countries: China, Hong Kong, India, Indonesia, Iran, Israel, Japan, Malaysia, Saudi Arabia, Singapore, South Korea, Taiwan, and Turkey. This study probed 30,515 articles published between 2000 and 2021, assessing each within four major bibliometric perspectives: (1) productivity, (2) authorship and collaborations, (3) top keywords, and (4) research impact. The results show that, in Asian ‘language and linguistics’ research, the relative contributions made by the 13 countries comprised 85% of the total number of articles produced in Asia. The other 28 Asian countries’ output, for the past two decades, never surpassed that of the individual 13 countries. Among the 13 countries, the most prolific were China, Japan, Hong Kong, and Taiwan; they especially published most articles in international core journals. In contrast, Indonesia, Iran, and Malaysia published more in regional journals. Traditionally, research on each country’s national language(s) and dialects were chiefly conducted throughout a period of 22 years. In addition, coping with internationalization worldwide, from 2010 onward, topics related to ‘English’ were of burgeoning interest among Asian researchers. Asian countries often collaborated with each other, and they also exerted a high degree of research influence on each other. The present study was designed to contribute to the literature on the comprehensive bibliometric analyses of Asian ‘language and linguistics’ research.
Existence of a cylinder foliated by periodic orbits in the generalized Chazy differential equation
Authors: Llibre Jaume , Novaes Douglas D. , Valls Claudia
Published: July 2023

The generalized Chazy differential equation corresponds to the following two-parameter family of differential equations x⃛+|x|qx¨+k|x|qxx˙2=0, which has its regularity varying with q, a positive integer. Indeed, for q=1, it is discontinuous on the straight line x=0, whereas for q a positive even integer it is polynomial, and for q>1 a positive odd integer it is continuous but not differentiable on the straight line x=0. In 1999, the existence of periodic solutions in the generalized Chazy differential equation was numerically observed for q=2 and k=3. In this paper, we prove analytically the existence of such periodic solutions. Our strategy allows to establish sufficient conditions ensuring that the generalized Chazy differential equation, for k=q+1 and any positive integer q, has actually an invariant topological cylinder foliated by periodic solutions in the (x,x˙,x¨)-space. In order to set forth the bases of our approach, we start by considering q=1,2,3, which are representatives of the different classes of regularity. For an arbitrary positive integer q, an algorithm is provided for checking the sufficient conditions for the existence of such an invariant cylinder, which we conjecture that always exists. The algorithm was successfully applied up to q=100.
Desynchronizing two oscillators while stimulating and observing only one
Authors: Mau Erik T. K. , Rosenblum Michael
Published: July 2023

Synchronization of two or more self-sustained oscillators is a well-known and studied phenomenon, appearing both in natural and designed systems. In some cases, the synchronized state is undesired, and the aim is to destroy synchrony by external intervention. In this paper, we focus on desynchronizing two self-sustained oscillators by short pulses delivered to the system in a phase-specific manner. We analyze a non-trivial case when we cannot access both oscillators but stimulate only one. The following restriction is that we can monitor only one unit, be it a stimulated or non-stimulated one. First, we use a system of two coupled Rayleigh oscillators to demonstrate how a loss of synchrony can be induced by stimulating a unit once per period at a specific phase and detected by observing consecutive inter-pulse durations. Next, we exploit the phase approximation to develop a rigorous theory formulating the problem in terms of a map. We derive exact expressions for the phase–isostable coordinates of this coupled system and show a relation between the phase and isostable response curves to the phase response curve of the uncoupled oscillator. Finally, we demonstrate how to obtain phase response information from the system using time series and discuss the differences between observing the stimulated and unstimulated oscillator.