bluuebunny/crossref_metadata_2025 huggingface dataset:
A clinical case of preservation of reproductive potential in a patient with invasive cervical cancer
Authors: Korneva O. V. , Trishkin A. G. , Chernyshova A. L. , Vyalova K. V.
Published: August 2023

Cervical cancer is a malignant tumor originating from the mucous membrane of the cervix (ectocervix or endocervix). In 2020, 604,000 new cases of the disease were registered, with 342,000 deaths. Today, a significant rejuvenation of this pathology is recorded – the highest incidence rate occurs in the age group from 15 to 39 years.

The cause of the development of cervical cancer is the human papillomavirus of oncogenic genotypes, and in Russia, human papillomavirus types 16 and 18 are found in most patients. Risk factors: early onset of sexual activity, frequent change of sexual partners, refusal of “barrier” type contraceptives, smoking, immunosuppression, the question of the influence of various sexually transmitted infections is being discussed.

The present article describes a clinical case of performing an organ-preserving operation: laparoscopic extended trachelectomy with sentinel lymph nodes determination, urgent cytological and histological studies, with the formation of the obturator apparatus with a soft titanium nickelide implant for invasive cervical cancer in a patient with unrealized reproductive function.

Organ-preserving surgeries in patients with cervical cancer allow preserving childbearing function while maintaining oncological radicality of surgical treatment. A modern, multidisciplinary approach of an oncologist-gynecologist and a reproductologist is the basis of a modern strategy for managing a patient with cervical cancer and unrealized reproductive function.
Incidence of postoperative complications in breast cancer patients depending on their tumor subtype and type of surgery
Authors: Ismagilov A. Kh. , Karasev V. E. , Vyushkov D. M.
Published: August 2023

Background. Breast cancer is distinguished by its heterogeneity. The biological subtype of the tumor influences the choice of treatment tactics, components of complex therapy. The appearance of targeted drugs made it possible to expand the indications of reconstructive plastic surgery in patients with breast cancer.

Aim. To study the influence of the biological subtype of breast tumor on the frequency of complications after simultaneous and delayed reconstructive plastic surgeries.

Materials and methods. The postoperative period of 577 patients 18–40 years with a diagnosis of stage I–IIIA unilateral breast cancer was studied. In 61.2 %, luminal cancer, subtype A, was verified, in 6.1 % – luminal cancer, subtype B, in 10.4 % – HER2-positive (luminal) ER+PR+, in 7.3 % – HER2-positive (non-luminal) ER–PR–, in 15 % – three times negative. All patients underwent surgical treatment, including, taking into account the indications and contraindications, in the volume of Madden mastectomy – 43.5 %, mastectomy with simultaneous two-stage reconstruction with silicone implants – 34.8 %, mastectomy with delayed two-stage reconstruction with silicone implants – 21.7 %.

Results. In most patients, the early postoperative period was favorable, complications were recorded in 11.8 %: in 11.3 % of patients of group I, 11.4 % of group II, 11.7 % of group III, 14.3 % of group IV, 12.6 % of group V. After radical mastectomy, complications were recorded in 13.5 % of cases, after mastectomy with simultaneous and delayed reconstruction – in 10.4 %. The treatment efficacy rate was 65.2–84.6 %. Late postoperative complications were recorded in group I in 24.1 % of patients, in group II – in 22.9 %, in group III – in 23.3 %, in group IV – in 26.2 %, in group V – in 24.1 %. Among patients who underwent only radical mastectomy, complications were noted in 24.7 %, mastectomy with simultaneous reconstruction – in 24.9 %, mastectomy with delayed reconstruction – in 21.6 %. The treatment efficacy rate was 42.9–59.5 %.

Conclusion. Our study did not reveal a relationship between the incidence of early and late postoperative complications in patients with different biological tumor types. Based on the literature, it can be assumed that not the type of tumor, but individually prescribed systemic therapy makes a significant contribution to the development of postoperative complications, which should be taken into account when planning reconstructive plastic surgeries.
Prognostic value of FOXA1 in patients with Т1–2N0M0 breast cancer
Authors: Paltuev R. M. , Kudaybergenova A. G. , Semiglazov V. F. , Komyakhov A. V. , Tseluyko A. I.
Published: August 2023

Background. New biomarkers of breast cancer are actively being studied to used them for breast cancer prognosis and develop optimal approaches to therapy. FOXA1 is one of these factors whose prognostic value for breast cancer has been analyzed in several studies.

Aim. To evaluate the prognostic value of FOXA1 in patients with T1–2N0M0 breast cancer.

Materials and methods. We measured FOXA1 expression in tumor cells of patients with hormone-dependent and hormone-independent breast cancer using the method developed by us (patent No. RU2748716C1 dated 03.06.2020). We performed immunohistochemical examination of tumor tissue using specific antibodies for staining. The Allred scale was used for results interpretation (to assess the number of cells with stained nuclei and the intensity of their staining). Then the total Allred score was calculated and used as a prognostic parameter. Patients with the Allred score between 4 and 8 had a favorable prognosis. We followed up patients in the groups and evaluated their survival. A univariate analysis was used to assess the risk of lethal outcome depending on the level of FOXA1 expression.

Results. In 75 % of patients with hormone-dependent and 82 % of patients with hormone-independent breast cancer (stages T1–2, N0 in both groups), the prognostic parameter measured using the Allred scale ranged between 4 and 8 points; their 10-year overall survival was 93 % and 92 %, respectively.

Conclusion. Our findings suggest high accuracy of our method for breast cancer prognosis. It can be used for breast cancer prognosis in early stages (T1–2, N0) and expands the range of techniques for breast cancer prognosis.
Male breast cancer. Clinical experience of the Russian Scientific Center of Roentgenradiology of the Ministry of Health of Russia
Authors: Khodorovich O. S. , Solodkiy V. A. , Astaturyan K. S. , Sherstneva T. V. , Kanakhina L. B. , Kleshneva V. O. , Tashchyan A. A. , Kalinina-Masri A. A.
Published: August 2023

Interest in male breast cancer is increasing every year due to the increase in the spread of this disease. However, the lack of randomized trials in male breast cancer draws the attention of specialists to this problem. Male breast cancer is 100 times less common than female. Over the past decades, there has been an increase in the disease up to 26 %. Low awareness of general practitioners, as well as the male part of the population, untimely access to specialized specialists are the reasons for the late diagnosis of the disease. Recommendations for the treatment of male breast cancer are based on the results of studies conducted in female with a similar diagnosis.

In the period from January 2015 to September 2022, 13 patients diagnosed with male breast cancer were examined and treated in the Department of Oncology and Reconstructive Plastic Surgery of the Breast of the Russian Scientific Center of Roentgenradiology, Ministry of Health of Russia. The age of patients at the time of treatment ranged from 58 to 75 years, with a mean age of 63 years. In 2 patients (15 %), stage 0 was established, in 4 (31 %) – stage Ia, in 4 (31 %) – stage IIa, in 1 (7.6 %) – stage IIb, in 1 (7.7 %) – stage IIIb, in 1 (7.6 %) – stage IIIc. Two (15 %) patients underwent neoadjuvant polychemotherapy, 6 (46 %) patients underwent adjuvant polychemotherapy. In 7 (54 %) patients, surgical treatment was performed without further adjuvant polychemotherapy. Six (46 %) patients underwent radiation therapy. Hormone therapy was prescribed to all 13 (100 %) patients. When contacting the clinic, the most frequent complaints would be the appearance of a seal behind the nipple, discharge from the nipple.

When diagnosing male breast cancer, the same methods are used as female. Tactics of treatment is determined individually. Early diagnosis of the disease and timely prescribed therapy lead to many years of remission.
Discovery of the style characteristics of the manifestation of management skills, necessary for officers in a combat environment
Authors:   Military Institute of Taras Shevchenko National University of Kyiv, Balabushka E.
Published: August 2023

The article presents the results of an empirical study of stylistic characteristics of the manifestation of management skills by officers in a combat environment. During the research, a number of personal characteristics were identified, which are most associated with a high level of management skills, which can be a prognostic indicator of the success of professional training and functioning of an officer in a combat environment. Distinguished stylistic features of the manifestation of management skills in a combat environment made it possible to identify officers of two types: universalplastic and rigid-fragmentary. They are distinguished by the adequacy of actions carried out by them in a combat environment, the completeness and quality of mastering the main groups of management skills (strength, functional plasticity, generalization), the nature of their actualization, the number and nature of errors and difficulties that are detected or experienced at various stages of activity, and as well as the connection of managerial skills with the effectiveness of activities. Based on the analysis of combat activity, it was established that the effectiveness of the implementation of management skills of officers in a combat environment is determined by a specific combination of a number of objective and subjective factors, the most important of which include: the content of the combat task; the nature of the enemy's influence; the officer's image of the combat situation, which he perceives as stimulating/neutral for starting/blocking a certain intellectual-behavioural pattern of combat behaviour; psychological readiness to act decisively in a non-standard environment; the repertoire of patterns and techniques for solving combat tasks mastered by the officer.
Justification, development and verification of the effectiveness of the educational and training program for forming the image of officers involved in the training of cadets
Authors:   Military Institute of Taras Shevchenko National University of Kyiv, L. Belichenko L. Belichenko
Published: August 2023

The article presents the results of an experimental verification of the effectiveness of the author's educational and training program for the formation of the image of officers involved in the training of cadets. Based on the theoretical analysis of the "image" category and the developed general system of image formation, a detailed study of the individual and psychological characteristics of the target audience (cadets) and image bearers (officers), an educational and training program was developed. It is aimed at forming a positive image of officers involved in training of cadets. The main methodical principle and mechanism of conducting any training is the opportunity to feel a lot of experiences that can be compared with experiences in real life. In particular, during the development of educational and training program, namely, the selection of training methods, following parameters were definitely taken into consideration: program tasks, program duration, group size, and what is extremely important, the level of the participants training, their previous experience, the degree of interpersonal interaction and expected activity of participants. The peculiarity of the educational and training program is not so much the passing of exercises for the development of professionally important and personal qualities of officers for the formation of a positive image, but interaction with cadets in an informal and unusual environment. Taking into consideration the specifics of the main subject of educational and training program, namely the "image" category, the proposed program can be related with both professionally oriented trainings and personal growth trainings. Therefore, the ETP provides an opportunity not only to acquire the necessary knowledge and skills for the formation of a positive image, to develop their professionally important and personal qualities, but also helps officers and cadets to show themselves from those sides that are hardly visible in everyday official activities, to look at the officer- cadet interaction on the other hand and perhaps do some re-evaluation of self and others.
Application of multi-criteria optimization method for decision-making in the sphere financial support of the military troops
Authors:   Military Institute of Taras Shevchenko National University of Kyiv, Artiushenko О.
Published: August 2023

The article considers the theoretical basis for the use of optimisation methods for managerial decision-making and search for an optimal solution. The article describes the methods of multi-criteria optimisation, which, based on the analysis of the relevant literature, are often used in various spheres of human activity, namely: simple additive weighting (SAW), elimination and choice expressing the reality (ELECTRE), preference ranking organisation method for enrichment evaluation (PROMETHEE), technique for order preference by similarity to ideal solution (TOPSIS), analytical hierarchy process (AHP), and analytical network process (ANP). The key characteristics of the decision-making environment in the field of military financial support are identified, based on the conditions and characteristics of such a decision-making environment, namely: a significant number of criteria to be taken into account, the presence of subjectivity in decision-making and the efficiency of such decisions, TOPSIS was chosen as the main method. In the methodological part of the article, the main characteristics, procedure of use and indicators of this method are considered. For practical application of the method, the article develops a case of decision-making by the military organisation A0001 regarding the optimal use of a limited financial resource out of 4 proposed options. In the article, a list of criteria was compiled, they were grouped, and a matrix was formed. In the final part of the article, a matrix of weighting coefficients for each of the 4 options is formed, its normalisation is carried out and the distance/closeness of the proposals of further solutions to the ideal solution is calculated. Based on the calculations, the author chose the optimal option for the use of financial resources, which, according to the TOPSIS method, had the smallest distance to the ideal solution, i.e., was the closest of the proposed options to the ideal option for the use of financial resources.
LITHUANIAN LANGUAGE RESOURCES INFORMATION SYSTEM "E. KALBA": FROM THE HISTORY, SEARCH POSSIBILITIES TO DEVELOPMENT PERSPECTIVES
Authors:   Institute of the Lithuanian Language, Gaidienė Anželika
Published: August 2023

This article presents the Lithuanian Language Resources Information System "E. kalba" ("E-Language"), which was developed at the Institute of the Lithuanian Language. The article therefore introduces the history of the development of "E. kalba", discusses the advantages of the system, shows how to perform a quick search in all or selected language resources, how to search for information of interest using wildcards, and briefly presents the statistics on the use of the system. The paper concludes with an introduction to the possible development perspectives of the system. From 2021, the system is freely available to the professionals and general public at https://ekalba.lt. The "E. kalba" provides access to 39 language resources, which are divided into three major groups: 1) e-dictionaries ("Dictionary of the Standard Lithuanian Language", "Dictionary of the Modern Lithuanian Language", "Dictionary of the Lithuanian Language", "Database of Lithuanian Language Neologisms", "Dictionary of Synonyms", "Lithuanian-English Dictionary", "German-Lithuanian Dictionary", etc.), 2) e-catalogues ("Main Catalogue of the ‘Dictionary of the Lithuanian Language’", "Catalogue of New Additions of the ‘Dictionary of the Lithuanian Language’", "Catalogue of Riddles", etc.), databases ("Database of Surnames", etc.), and 3) e-services ("WordNet search", "E-terms", "E-names", "Sentiment Analysis", "Word Formation Guide", "Language Advice", "Educational Language games", etc.). In addition to being a treasure trove of linguistic resources, "E. kalba" is also a multi-criteria search tool, with an effective and sophisticated search mechanism (quick and detailed search, search across all resources or within each resource, etc.). "E. kalba" offers a user-friendly way to view search results – results can be downloaded and saved in PDF and XML formats, and results can be shared on "Facebook". The system is also mobile-friendly.
MYKHAILO HRUSHEVSKY AS A HISTORIAN OF UKRAINIAN FOLKLORE
Authors:   Ivan Franko National University of Lviv, Harasym Yaroslav
Published: August 2023

The article highlights Mykhailo Hrushevskyi’s scientific views on the problem of historicism of the Ukrainian oral literature and periodization of folk songs. The scientific and critical reception of the historical literary strategies of the author, the essence of the main discussion questions addressed by the reviewers is clarified to the researcher. Based on the analysis of folkloristic volumes "History of Ukrainian Literature" and separate ethnological works of the scientist trace the formation of the methodological foundations of M. Hrushevskyi, a folklorist, established their conceptual affiliation to the positivist stage of Ukrainian cultural historical school, it was found that some of his research ideas corresponded to the provisions of the French school genetic sociology. The folkloristic development’s study of one of the most authoritative historians of the late 19th and early 20th centuries showed the scientific productivity of his conceptual considerations regarding the chronology of folklore phenomena and their application in further folklore studies. In the theoretical aspect, the problem of the relation between folklore and literature in the research from the point of M. Hrushevskyi is revealed, which is considered in two interwoven planes: 1) the origin of oral folk literature and its specifics; 2) the issue of common study of folklore and literature. It has been found that, using the inductive method in the interpretation of the folklore tradition, M. Hrushevskyi had critical attitude towards the extremes of comparativism and at the same time he deeply respected the research effectiveness of the historical-comparative method of studying and clarifying similarities and borrowings, as well as determining the national specificity of oral Ukrainian literature. As a scientist with a historical mindset, the researcher penetrates through the layers of centuries and millennia, presents a scientifically based chronology of the stages of the development of Ukrainian folklore, explains the theory of the origin of literature, tries to trace the oral literature before the Slavs’ settlement and after it, catches the echo of creativity of tribal times, researches and reconstructs army poetry.
Ultrasound navigation in pediatric intensive care unit: Realities of the present
Authors: Aleksandrovich Yuriy S. , Pshenisnov Konstantin V. , Ermolenko Kseniya Yu. , Ulrikh Gleb E. , Prometnoy Dmitry V. , Evgrafov Vladimir A.
Published: August 2023

BACKGROUND: There have been an increasing number of publications in recent years demonstrating the efficiency and safety of ultrasound imaging techniques in anesthesiology and intensive care, which reduce the risk of complications during invasive manipulation and detecting life-threatening conditions at the earliest stage; however, practical implementation of these techniques is associated with significant difficulties, which served as the basis for this research.
AIM: To estimate the adherence of experts in pediatric anesthesiology and intensive care departments to using ultrasound imaging techniques in clinical practice.
MATERIALS AND METHODS: A voluntary, anonymous questionnaire study of pediatric intensive care unit heads in 65 Russian Federation regions was conducted.
RESULTS: Responses were obtained from 32 (38.4%) respondents. In 30% of cases, the work experience of specialists in the pediatric intensive care unit was around 510 yr, and there was no relationship between the introduction of ultrasound imaging techniques into the departments routine practice and the work experience of the specialists. All the professionals who participated in the study had access to an ultrasound scanner 24 h per day, 7 days a week. When measuring adherence to the use of ultrasound imaging techniques in providing venous access, five (15%) hospitals did not utilize them at all, whereas four (12.5%) medical institutions used them 100% of the time. The average frequency of main vein catheterization using ultrasonic imaging techniques is 49 35.5%. Ultrasonography is used to examine cardiac systolic function by 26 (81) respondents and it is routine in 50% of patients who require continuous catecholamine infusion. The Teicholz method (56% of the time) is used to assess systolic cardiac function; the Simpson method was used in 34% of cases. Ultrasound imaging to assess pulmonary status is used by 56% of responders. It is only used routinely in 28% of patients who require controlled mechanical ventilation. Ultrasound imaging is used in 47% of cases to examine the status of breathing volume. In 72% of instances, ultrasonography is used to assess cerebral perfusion and diagnose intracranial hypertension syndrome. Ultrasound-imaging methods are used by 56% of responders for screening diagnoses of life-threatening disorders in children with polytrauma, and in 44% of cases, it is a routine assessment. Fifty-seven percent of respondents believe that ultrasound diagnostic techniques are highly effective, and 71% believe that their use is safe for patients.
Representasi kekerasan seksual terhadap perempuan dalam Film “2037” (studi analisis semiotika Ferdinand de Saussure)
Authors: Nurhidayah Ika Amiliya , Bakhri Syamsul , Baharuddin M. Achwan
Published: August 2023

One of the developments in communication technology that occurs today is the presence of various communication channels or 'media' in the process of delivering ideas, messages, or ideas. The variety of communication media has become the most effective method today in the formation of a person's point of view and behavior. In this study, researchers are interested in making one of the three types of communication media, namely audio-visual communication media in the form of films. Film is claimed to be a mass media that has a dominant influence than other media, this is due to the influence of psychology on films which is fundamental in the formation of opinions and people's psyche. Researchers are interested in examining a film entitled "2037" as a medium of representation of sexual violence against women. This study aims to identify signs or symbols that represent sexual violence against women in the 2037 film using Ferdinand de Saussure's semiotic theory as his analysis knife. The method applied in this study is qualitative with a data analysis model using semiotic analysis by Ferdinand de Saussure, which is based on signifiers and signified. The results and discussion showed that there were three types of sexual violence against women represented in the film "2037" based on markers and markers that had been found, including forced marriage, verbal abuse, and sexual harassment.

Salah satu perkembangan teknologi komunikasi yang terjadi saat ini adalah hadirnya alat saluran komunikasi atau 'media' yang beragam dalam proses penyampaian ide, pesan, ataupun gagasan. Beragamnya media komunikasi telah menjadi metode paling efektif saat ini dalam pembentukan sudut pandang dan perilaku seseorang. Dalam penelitian ini, peneliti tertarik untuk menjadikan salah satu dari ketiga jenis media komunikasi tersebut yaitu media komunikasi audio-visual berupa film. Film diklaim sebagai media massa yang memiliki pengaruh dominan daripada media lain, hal tersebut disebabkan karena adanya pengaruh psikologi pada film yang fundamental dalam pembentukan opini dan jiwa masyarakat. Peneliti tertarik untuk mengkaji sebuah film berjudul "2037" sebagai media representasi dari kekerasan seksual terhadap perempuan. Tujuan dari penelitian ini adalah untuk mengidentifikasi tanda-tanda atau simbol-simbol yang merepresentasikan kekerasan seksual terhadap perempuan dalam film 2037 dengan menggunakan teori semiotika Ferdinand de Saussure sebagai pisau analisisnya. Metode yang diaplikasikan dalam penelitian ini adalah metode kualitatif dengan model analisis data menggunakan analisa semiotika oleh Ferdinand de Saussure yang berprinsip pada penanda (signifier) dan pertanda (signified). Hasil dan pembahasan menunjukkan adanya 3 jenis kekerasan seksual terhadap perempuan yang direpresentasikan dalam film "2037” berdasarkan penanda dan petanda yang telah ditemukan, diantaranya adalah pemaksaan perkawinan, pelecehan verbal, dan pelecehan seksual.
Pengembangan media pembelajaran Majalah Inspiratif Sejarah (Manis) pada materi peran Raden Tumenggung Sosrokusumo I dalam islamisasi masyarakat Kabupaten Nganjuk Tahun 1830-1832 M
Authors: Fritambiradi Didit Ditya , Ayundasari Lutfiah
Published: August 2023

This study aims to develop learning media in the form of an inspirational historical magazine 'MANIS' on the material of the role of Raden Tumenggung Sosrokusumo I in the Islamization of the people of Nganjuk Regency in 1830-1832 M in class XI IPS SMA Diponegoro Nganjuk based on the results of an analysis of the potential and problems of the research subjects. This study uses the Research and Development (R&D) method with a model developed by Sugiyono, covering potentials and problems, collecting data, product design, design validation, design revision, product trials, product revisions, usage trials, product revisions and mass production. However, this research and development only used nine of the ten steps of the procedural model. The analysis technique in this study uses qualitative analysis and quantitative descriptive. Based on the data validation results, 95 percent was obtained for material validation and 90 percent for media validation, while the small group trial obtained 74.8 percent and the large group trial obtained 85.3 percent. Based on these percentage values, it can be concluded that historical inspirational magazine learning media are valid and effective as historical learning media in class XI IPS SMA Diponegoro Nganjuk.

Penelitian ini memiliki tujuan untuk mengembangkan media pembelajaran berupa majalah inspiratif sejarah ‘MANIS’ pada materi peran Raden Tumenggung Sosrokusumo I dalam islamisasi masyarakat Kabupaten Nganjuk tahun 1830-1832 M pada kelas XI IPS SMA Diponegoro Nganjuk yang berdasarkan hasil analisis potensi dan masalah subjek penelitian. Penelitian ini menggunakan metode Research and Development (R&D) dengan model yang dikembangkan oleh Sugiyono, meliputi potensi dan masalah, mengumpulkan data, mendesain produk, validasi desain, revisi desain, uji coba produk, revisi produk, uji coba pemakaian, revisi produk dan produksi massal. Penelitian dan pengembangan ini hanya menggunakan sembilan langkah dari sepuluh langkah model prosedural tersebut. Teknik analisis dalam penelitian ini menggunakan analisis kualitatif serta deskriptif kuantitatif. Berdasarkan hasil validasi data mendapatkan nilai persentase 95 persen untuk validasi materi dan 90 persen untuk validasi media, sedangkan untuk uji coba kelompok kecil mendapatkan hasil 74,8 persen dan uji coba kelompok besar mendapatkan hasil 85,3 persen. Berdasarkan nilai persentase tersebut mendapatkan kesimpulan bahwa media pembelajaran majalah inspiratif sejarah valid dan efektif digunakan sebagai media pembelajaran sejarah di kelas XI IPS SMA Diponegoro Nganjuk.
A Survey of Behaviors, Beliefs, and Perceptions of COVID-19 in Rural Appalachian Ohio
Authors: Jinka Sanjay K. A. , Natarajan Jay P. , Kubina Matthew , Glover Jennifer A. , Nam Julie , Mansoor Sanaa , Leahy Charles , Kotsch Troy , Fischbein Rebecca , Appleman Mike
Published: August 2023

Background: Preventing the spread of COVID-19 comes with many challenges. Considering the sociobehavioral effects of social distancing in rural communities specifically is incredibly important. No previous studies have been published about adherence to COVID-19 preventative measures and viewpoints on vaccination/other prevention measures in the rural Appalachian region of Ohio specifically. This present study will describe the results of a survey regarding perceptions of COVID-19 in rural communities.Methods: A 20-question cross-sectional survey was administered over a 6-week period from February to April 2021. Survey distribution was completed via flyers with QR codes hung at 4 medical offices in Columbiana and Tuscarawas counties. The survey was adapted from the standardized FluTEST survey. Descriptive statistics and bivariate analyses were used for comparison.Results: We had 23 respondents after removing incomplete/nonconsenting responses. Our data showed that contracting COVID-19 was associated with vaccine distrust. Females and those with health risk factors were found to be more cautious when compared to males and those without risk factors, respectively. Respondents under age 65 years were more likely to trust government health agencies. Those with emotional distress were more likely to take precautions in relation to the COVID-19 pandemic.Conclusion: To prevent widening health inequalities in the particularly vulnerable population of Appalachia, further study with larger sample size should be conducted. This information can be used by health care providers to tailor patient education regarding COVID-19 vaccine administration, treatment, and prevention measures.
Bridging the Gaps in Women's Primary Care for Those Treated at a Residential Drug Treatment Facility in Southwest Ohio
Authors: Squibb Anna , Subler Bradley , Wu Tongfan , Rings Vijay K. , Collins Khadijah C.
Published: August 2023

Background: Patients with substance use disorders (SUD) have higher rates of sexually transmitted infections (STI) and limited utility of preventive and outpatient primary care. Women with SUD are a particularly vulnerable population requiring consistent primary and reproductive health care. This study evaluated the need for providing women’s primary health care to patients in a residential SUD treatment facility in rural southwest Ohio.Methods: A retrospective chart review was conducted using intakes at a female-only residential SUD treatment facility from 2021-2022. Variables recorded in this study were: 1) patient-reported substance use; 2) laboratory screenings for hepatitis B, hepatitis C, HIV, and STIs; 3) reproductive history (contraceptive, Papanicolaou (Pap) test, and pregnancy history); 4) patient-reported connection with a primary care provider (PCP); and 5) patient-reported mental health disorders. The analysis provided descriptive statistics to identify comorbidities and trends in women with SUD.Results: All completed intake charts were reviewed (n=159) without exclusions. No current PCP was reported in 59% of patients. Papanicolaou tests were needed in 50% of patients, and, of those completed, six (21%) had abnormal results. Almost 20% of patients were found with a positive STI, with highest prevalence of trichomoniasis (23%). Viral infection rate was 42%, the most common being hepatitis C (35% with active infection). Patient-reported comorbid psychiatric illness was 90%, the most common being generalized anxiety disorder (GAD) at 67.3%.Conclusion: This study supports the need for whole person primary care in residential SUD treatment facilities, particularly in respect to viral and sexually transmitted infections, and for overall women's health.
The Online Identity Construction of the Elderly Women— Take Chinese Discourse Marker “Ah” as an Example
Authors: Cui Dan , Zhao Yaxuan
Published: August 2023

Recently, the registration of the elder user in cyberspace roses repeatedly. More and more old people prefer to realize self-expression through the Internet, among which the elderly woman is the majority. Based on self-constructed corpus, this paper examines the pragmatic functions of the Chinese discourse marker “Ah”, and discusses what kinds of pragmatic identity has been constructed. This paper discovers that, on the one hand, discourse marker “Ah” realizes topic organization function and interpersonal function; on the other hand, “ah” assists the elderly in constructing female identity, expert identity, elder identity and peer identity, and sometimes a compound identity of real and virtual identities so as to narrow the psychological distance with the audience and achieve the communicative purpose.
Environmental Force, Transcendence, and Freedom in Crouching Tiger, Hidden Dragon: On the Mystery of Jen’s Jumping off Wudang Mountain
Authors: Yao Xiujuan
Published: August 2023

In Crouching Tiger, Hidden Dragon, there is a complex relationship between characters and their surroundings. One dominant power is the environmental force, which affects these people’s decisions and behaviors, either negatively or positively. Jen, as the main character, attempts to transcend her civilized society by wandering into the opposite world, the wilderness. Yet in both civilized and wild environments, Jen fails to gain her freedom. In the civilized world, she is constrained by her traditional gender role, according to which she has to submit herself to patriarchal elders. Leaving the civilized world for the wilderness, Jen wants to create a system of her own, according to which she has the power to dominate others. Despite her effort in maintaining the system, she is not successful in gaining her freedom, because she has to deal with her irrationality of attaining excessive power. A relinquishment of her delusion of power eventually leads Jen to realize how to have a self-sufficient sphere of her own. Through the symbolic act of jumping from the physical Wudang Mountain to the spiritual world of eternity, Jen connects herself to the spiritual universe; accordingly, she gains her freedom with sacredness.
A Cognitive Analysis of Multimodal Metaphors in News Cartoons Based on Conceptual Integration TheoryA Cognitive Analysis of Multimodal Metaphors in News Cartoons Based on Conceptual Integration Theory
Authors: Li Chen
Published: August 2023

The meaning construction and interpretation of metaphor exist in verbal and non-verbal forms (multimodal forms such as sound and color). As the carrier of verbal and non-verbal symbols, the function of news cartoons is far greater than that of words. Based on the conceptual integration theory, this paper analyzes the multimodal metaphor phenomenon and meaning construction process of news cartoons with the theme of “uniting as one to fight the epidemic” selected from China News Cartoons Network. The research finds that the multimodal metaphorical representation of “uniting as one to fight the epidemic” reflects people’s basic cognition, which is affected by one’s experience, history and culture; the meaning construction of the multimodal metaphorical scene of “uniting as one to fight the epidemic” has the characteristics of dynamic processing. This paper aims to enhance people’s awareness of novel coronavirus through the cognitive interpretation of multimodal metaphors in news cartoons.
Legendary Expatriation of American Women Writers: Salon Coteries in Adventures of the Mind and The Autobiography of Alice B. Toklas
Authors: Wang Yuanjiang
Published: August 2023

The expatriate life of American women writers based upon salon coteries in Paris in the early 20th century is probed into in this paper. The expatriate American women writers constructed an impressive female community through artistic salons led by Natalie Clifford Barney and Gertrude Stein as well as cosmopolitan bookshops run by Sylvia Beach and Adrienne Monnier. When post-war despair and cultural bankruptcy prevailed, they found a new approach in a different world, far from their hometown, and thus promoting American-European cultural exchanges, diversifying modernist ecosphere. The influx of expatriate women also benefited gender equality and feminist writing. Salon coteries reflected their quest for emancipation under constraints and nurtured collective creativity. In the modernist hemisphere belonging to them, the expatriate women writers shared new modes of language, and found their own freedom to write, to voice, to live. The innovation of the paper is the detailed study of salon hostesses Barney’s memoir Adventures of the Mind and Stein’s life narrative The Autobiography of Alice B. Toklas, with the analysis of public sphere theory and life-writing theory to highlight the memory of collaborative salon space—a created gender-equal sphere of women writers, and their self-discovery spirit in the legendary expatriation.
Cicero’s Metaphor Hypotheses Revisited: An Inter-disciplinary Approach to the Aesthetic Appeal of Novel Metaphors
Authors: Qiu Zhouyan
Published: August 2023

Metaphor permeates almost everywhere, and novel metaphors in particular are supposed to be more aesthetically appealing. Given the lack of a systematic research on the aesthetics of linguistic forms, this paper aims at investigating the factors contributing to novel metaphors’ aesthetic appeal. This study takes as a point of departure the great Roman rhetorician Marcus Tullius Cicero’s four hypotheses about the contributing factors to metaphor’s aesthetic appeal. These hypotheses prove to be reasonable based on our wide-ranging study on the relevant researches of inter-disciplinary interests in such fields as linguistics, psychology, neurology and aesthetics. Vivid images, pleasure in comprehension and meaning inexhaustibility are found to be the three potential contributing factors. Presumably, this inter-disciplinary endeavor will shed light on our investigation into the aesthetics of novel metaphors.
Microangiopatías trombóticas: púrpura trombocitopénica trombótica y síndrome hemolítico urémico. Una revisión más allá del espectro clínico de la enfermedad
Authors: Saavedra Valencia Miguel Eduardo , Martinez-Sanchez Lina Maria , Vergara Yanez Daniela , Arrieta Sibaja Jose David
Published: August 2023

La microangiopatía trombótica se relaciona con una lesión histológica en las arteriolas y los capilares; se caracteriza por engrosamiento e inflamación de la pared vascular, desprendimiento de células endoteliales, ampliación del espacio subendotelial por acumulación de proteínas, material de lisis celular y trombos plaquetarios que ocluyen la luz vascular. Hay dos enfermedades con lesiones de microangiopatía trombótica primaria: la púrpura trombocitopénica trombótica y el síndrome hemolítico urémico. La púrpura trombocitopénica trombótica se relaciona con un déficit o disfunción de la actividad de la desintegrina y la metaloproteasa, que escinden el enlace del factor de von Willebrand; una proteína que participa en el proceso de la coagulación. Desde el punto de vista clínico se caracteriza por una anemia hemolítica microangiopática, trombocitopenia y aumento de la deshidrogenasa láctica sérica. El síndrome hemolítico urémico se define por la anemia hemolítica microangiopática, trombocitopenia y la lesión renal aguda. Se clasifica en típico y atípico. El primero se asocia con el pródromo de diarrea posterior a una infección por Escherichia coli productora de toxina Shiga. Por su parte, el síndrome hemolítico urémico atípico se relaciona con anormalidades en la vía alternativa del complemento, infecciones por Streptococcus pneumoniae, lupus eritematoso sistémico, trastornos del metabolismo de la cobalamina C, entre otros.
Aciduria glutárica tipo I: reporte de un caso con diagnóstico tardío
Authors: López Rodríguez Victor Rubén de Jesús , Chima Galán María Del Carmen , Parra Guerrero Lina , Navarro Estrada Mariana , Santillán Hernández Yuritzi , Vargas Quevedo Ericka
Published: August 2023

ANTECEDENTES: La aciduria glutárica tipo I es un error innato del metabolismo ocasionado por variantes en GCDH que dan origen a una deficiencia de la enzima glutaril-CoA deshidrogenasa que, a su vez, produce acumulación de metabolitos neurotóxicos y un cuadro clínico caracterizado por lesión estriatal y trastornos del movimiento (distonía, coreoatetosis).CASO CLÍNICO: Paciente de tres años de edad, previamente asintomático hasta el inicio de una crisis encefalopática a los 10 meses, posteriormente con regresión de hitos del desarrollo, hipotonía central y movimientos involuntarios. Con el antecedente de laringomalacia, orzuelos de repetición, tos productiva crónica, alteración en el patrón de evacuaciones, hiperhidrosis generalizada y múltiples hospitalizaciones por infecciones respiratorias. La resonancia magnética cerebral reportó aumento del espacio subaracnoideo frontotemporal bilateral y de las cisuras de Silvio, globo pálido, putamen y caudado con atrofia bilateral, hiperintensos en T2/FLAIR y con restricción a la difusión. El análisis de los ácidos orgánicos demostró elevación del ácido glutárico y la secuenciación de GCDH reportó dos variantes patogénicas: p.Arg402Trp y p.Thr429Met.

CONCLUSIONES: Se reporta un caso de aciduria glutárica tipo I con diagnóstico tardío y dos variantes patogénicas en GCDH no comunicadas previamente en población mexicana. El tratamiento oportuno de la aciduria glutárica tipo I cambia radicalmente el pronóstico; sin embargo, depende de métodos de cribado para el diagnóstico temprano, que no se encuentran disponibles en todas las poblaciones.
Lactante masculino con inmunodeficiencia combinada grave
Authors: RAMIREZ - RISTORI ALFONSO GILBERTO , Nakashimada Marco Antonio Yamazaki , Abril Marco Antonio Sarmiento
Published: August 2023

Paciente masculino que falleció a la edad de ocho meses, hijo de padres aparentemente sanos, con antecedente de muertes, en la primera infancia, de niños varones de la línea materna. Su último padecimiento se inició a los 6 a 7 meses de vida, con un cuadro catarral caracterizado por rinorrea y coriza. Por este motivo fue llevado a consulta con un médico particular, quien le prescribió amoxicilina durante cinco días. Al cuadro catarral se agregaron: tos no productiva, irritabilidad, fiebre y evacuaciones disminuidas en consistencia. Fue llevado al Instituto Nacional de Pediatría debido a los síntomas y cumplir con criterios de sospecha de COVID 19. El paciente recibió la vacuna BCG al nacimiento.
El triángulo necesario: médicos, arquitectos y administradores de hospitales en la ciudad de México, 1940-1950
Authors: Agostoni Claudia
Published: August 2023

El estudio de la crucial interacción y colaboración de los saberes de médicos, arquitectos y administradores para materializar la reforma hospitalaria emprendida en México a partir de la década de 1940 es el eje que articula el presente trabajo. Cómo se gestó esa colaboración de saberes expertos, cuáles fueron algunos de los diagnósticos y propuestas que realizaron, y cuáles algunas de las limitaciones que enunciaron, son temáticas que no obstante su relevancia, no han ocupado un espacio destacado en las investigaciones históricas. Con ello, este artículo busca contribuir al estudio de la primacía que la resolución del problema médico-asistencial tuvo a lo largo de la década de 1940 y durante los años iniciales de la década siguiente, un momento de intensa innovación y ampliación de los espacios hospitalarios.
Repercussões Emocionais, Sociais e na Rotina em Mulheres Vítimas de Stalking
Authors: Alves Bianca Zambelli , De Antoni Clarissa
Published: August 2023

O stalking é um fenômeno caracterizado por comportamentos de perseguição e assédio à vítima. O objetivo deste estudo foi conhecer a percepção de mulheres vitimadas pelo comportamento stalker a respeito das repercussões em suas vidas. Foram entrevistadas seis jovens mulheres, entre 22 e 28 anos. Os instrumentos utilizados foram uma ficha de dados sociodemográficos e uma entrevista individual semiestruturada, ambos elaborados pelas pesquisadoras. Por meio da Análise Temática encontraram-se três modalidades das repercussões existentes: emocionais, sociais e nas rotinas. Nas repercussões emocionais aparecem o medo, a culpa, o incômodo e a raiva; nas repercussões sociais emergem as consequências nos relacionamentos e nas redes sociais; já nas repercussões na rotina, discutem-se as alterações nas atividades diárias e no deslocamento físico. Por fim, compreende-se que as repercussões desencadeadas pelo stalking vivenciado são severas e estão inter-relacionadas numa circularidade causal. Essas repercussões afetam negativamente a vida dessas mulheres e provocam um sofrimento intenso.
Percepção de Universitários Sobre a Interface Entre Lazer, Religiosidade e Bem-estar Espiritual
Authors: Maciel Marcos Gonçalves , Oliveira Junior Galdino Neto de , Mota Jorge Augusto Pinto da Silva
Published: August 2023

O presente trabalho teve como objetivo analisar se as vivências de lazer no contexto religioso contribuem para o desenvolvimento do bem-estar espiritual em universitários. Trata de uma pesquisa de caráter misto, transversal, exploratória e estudo de caso. A amostra foi selecionada por conveniência; participaram 108 pessoas (29,8±10,4 anos), sendo 61,1% de mulheres. Em relação a adesão às religiões/crenças, houve a seguinte distribuição: umbanda (2,8%), ateu (6,5%), espírita kardecista (6,5%), evangélica (33,3%), católica (37,0%), outros (13,9%). Foi aplicado, via Google Forms, um questionário semiestruturado e a escala de bem-estar espiritual validada para o português. Foram adotadas escalas Likert de 5 pontos para o registro das respostas, analisadas por meio de médias. Os resultados demonstram uma média de 4,4 em concordância de que as atividades de lazer realizadas no contexto religioso contribuem para a promoção do bem-estar espiritual; em relação à percepção de bem-estar espiritual foi identificado uma média geral de 3,8. Considera-se que as atividades de lazer no contexto religioso, independentemente do sexo, estado civil, crença, podem atuar como fator de promoção do bem-estar espiritual entre os universitários.
Инновационная деятельность на предприятиях нефтегазового комплекса
Authors: Силизнёв С.В.
Published: August 2023

В данной статье были изучены состояние и направления инновационной деятельности на предприятиях нефтегазового комплекса. Рассмотрены актуальные проблемы и возможные способы их разрешения, механизмы эффективного управления инновационной деятельностью. После анализа подобных точек зрения, сделан вывод по улучшению ситуации на рынке.
Анализ современного состояния рынка лечебного питания
Authors: Фазуллина О.Ф. , Смирнов С.О.
Published: August 2023

Специализированное лечебное питание обеспечивает нутриционную поддержку пациентов при тяжелых состояниях здоровья, например, при онкологических, инфекционных заболеваниях, постинсультных состояниях, послеоперационный период. Возможны два вида поддержки: энтеральное или парентеральное питание. Сегодня на рынке представлено много продуктов для нутриционной поддержки и рынок продолжает развиваться.
Метод пьезоэлектрического управления светодиодным освещением
Authors: Лаврин М.С.
Published: August 2023

В статье рассматривается возможность применения пьезоэлектрического эффекта для управления яркостью светодиодных ламп.