bluuebunny/crossref_metadata_2025 huggingface dataset:
Cell Surface Fibroblast Activation Protein-2 (Fap2) of Fusobacterium nucleatum as a Vaccine Candidate for Therapeutic Intervention of Human Colorectal Cancer: An Immunoinformatics Approach
Authors: Padma Somrita , Patra Ritwik , Sen Gupta Parth Sarthi , Panda Saroj Kumar , Rana Malay Kumar , Mukherjee Suprabhat
Published: February 2023

Colorectal cancer (CRC) is one of the most common cancers and is the second-highest in cancer-related deaths worldwide. The changes in gut homeostasis and microbial dysbiosis lead to the initiation of the tumorigenesis process. Several pathogenic gram-negative bacteria including Fusobacterium nucleatum are the principal contributors to the induction and pathogenesis of CRC. Thus, inhibiting the growth and survival of these pathogens can be a useful intervention strategy. Fibroblast activation protein-2 (Fap2) is an essential membrane protein of F. nucleatum that promotes the adherence of the bacterium to the colon cells, recruitment of immune cells, and induction of tumorigenesis. The present study depicts the design of an in silico vaccine candidate comprising the B-cell and T-cell epitopes of Fap2 for improving cell-mediated and humoral immune responses against CRC. Notably, this vaccine participates in significant protein–protein interactions with human Toll-like receptors, especially with TLR6 reveals, which is most likely to be correlated with its efficacy in eliciting potential immune responses. The immunogenic trait of the designed vaccine was verified by immune simulation approach. The cDNA of the vaccine construct was cloned in silico within the expression vector pET30ax for protein expression. Collectively, the proposed vaccine construct may serve as a promising therapeutic in intervening F. nucleatum-induced human CRC.
A Polysaccharide-RBD-Fc-Conjugated COVID-19 Vaccine, SCTV01A, Showed High Immunogenicity and Low Toxicity in Animal Models
Authors: Sun Chunyun , Kong Desheng , Guo Erhong , Zhao Jun , Jia Jilei , Wang Rui , Ma Juan , Chen Meng , Lu Jianbo , Yu Chulin , Li Kuokuo , Xie Liangzhi
Published: February 2023

We previously developed a polysaccharide-–RBD-conjugated nanoparticle vaccine which induced protective efficacy against SARS-CoV-2 in a mouse model. Here, we newly developed a vaccine, SCTV01A, by chemically conjugating recombinant SARS-CoV-2 RBD-Fc and PPS14 (Streptococcus pneumoniae serotype type 14 capsular polysaccharide). The immunogenicity and toxicity of SCTV01A were evaluated in animal models. The PPS14 conjugation enhanced the immunogenicity of RBD-Fc in C57BL/6 mice whether formulated with SCT-VA02B or Alum adjuvant. SCTV01A also induced high opsonophagocytic activity (OPA) against S. pneumoniae serotype 14. In addition, SCTV01A stimulated potent neutralizing titers in rhesus macaques and effectively reduced lung inflammation after SARS-CoV-2 infection with neither antibody-dependent enhancement (ADE) nor vaccine-enhanced diseases (VED) phenomenon. Importantly, the long-term toxicity study of SCTV01A in rhesus macaques did not cause any abnormal toxicity and was tolerated at the highest tested dose (120 μg). The existing immunogenicity and toxicological evaluation results have demonstrated the safety and efficacy of SCTV01A, which will be a promising and feasible vaccine to protect against SARS-CoV-2 infection.
Effect of Feeding Pomegranate (Punica granatum) Peel and Garlic (Allium sativum) on Antioxidant Status and Reproductive Efficiency of Female Rabbits
Authors: Hagag Omnia Y. Abd-Elfadiel , Younis Fawzy El-Essawy , Al-Eisa Rasha A. , Fayad Eman , El-Shenawy Nahla S.
Published: February 2023

Egypt’s animal protein shortfall cannot be overcome by expanding the production of large animals alone, but rather by increasing the production of highly reproducing animals in the livestock unit. The goal of this study was to examine how adding pomegranate peel (PP), garlic powder (GP), or a mixture of the two to the diet of does affect their weight, the number of offspring, reproductive performance, hematological indices, and several antioxidants indicators as well as the liver and kidney functions. A total of 20 adult and mature female mixed rabbits at age 4.5–5 months and averaging 3.05 ± 0.63 kg body weight, were allocated into four experimental groups (n = 5). The first group was provided with the basal diet and was considered as control animals, while the second, third, and fourth groups were fed the basal diet supplemented with PP 3.0%, GP 3.0%, and a mixture of PP 1.5% + GP 1.5%, respectively. After 2 weeks of feeding the experimental diets, natural mating with untreated bucks was carried out. The kits were weighed immediately after parturition, and then every week. The study found that rabbits fed with 3% PP led to a 28.5% increase in the number of kits at birth compared to the control group. As an effect of supplementing PP 3%, GP 3%, and PP 1.5% + GP 1.5%, the birth weight increased by 9.2%, 7.2%, and 10.6%, respectively, as compared to the control. Hemoglobin increased significantly in all treatment groups as compared to the control at the age of kit weaning. Lymph cells increased significantly in the rabbits that were fed with GP (3%) than in other groups and even the control. The results showed that creatinine levels were significantly decreased in the PP (3%) and GP (3%) than in control rabbits. The level of triglycerides significantly declines in groups treated with PP (3%) than in other treatment groups and the control. The addition of PP 3% or GP 3% increased the progesterone hormone. The addition of PP 1.5% + GP 1.5% improved the immunoglobulin IgG. The results of superoxide dismutase, catalase, glutathione, and total antioxidant capacity showed a significant decline in groups treated with GP (3%) than other treated groups. In conclusion, pomegranate is a promising substance to include in a rabbit’s diet, followed by garlic to boost reproductive efficiency.
Entrepreneurial Engagements
Authors: Akabuike Chikelue Chris
Published: February 2023

This study addresses the experiences of undergraduate entrepreneurs, including what motivates them, their challenges, and how they navigate both entrepreneurial activities and academic work. Using a snowball approach, a qualitative research design involving fifteen purposively selected respondents from among the sculpture students of the Nsukka Art School was used as a case study. Data collection and analysis were conducted using a semi-structured interview and a thematic analysis approach, respectively. Findings show that respondents are actively involved in entrepreneurial deeds within multiple non-sculpture related fields such as painting, graphic, communication design, T-shirt printing, portrait making, and utility wood sculptures. They are motivated by the quest to address personal financial constraints. Such entrepreneurial quests, however, expose them to specialization and operational, marketing, and managerial challenges. It is recommended that policymakers in academia, industry, and government work together toward repositioning student entrepreneurs by creating the enabling environment for economic growth. While a further study is needed to understand how undergraduates navigate their managerial challenges, the nuanced performance and difference in age and gender is noteworthy.
Endoscopic ultrasound in diagnosis and management of some gastrointestinal - pancreaticobiliary diseases at Hue University of Medicine and Pharmacy Hospital
Authors: Truong Xuan Long , Vinh Khanh
Published: February 2023

Background: Gastrointestinal - pancreaticobiliary diseases is a major pathology relating to organs from the mouth to the anus and biliary tree. Endoscopic ultrasound (EUS) helps to assess deeper organs in the abdomen such as pancreas, biliary tree, lesions inside and outside the alimentary tract as well as regional lymph nodes. We proceeded this study to: (1) To examine some characteristics of patients, indications and safety of EUS, (2) To evaluate roles of EUS in diagnosis and management of gastrointestinal - pancreaticobiliary diseases. Materials and method: A cross-sectional study was conducted on 1615 patients undergoing endoscopic ultrasound at Hue University of Medicine and Pharmacy Hospital. Results: Male:female ratio = 1.4:1. Average age was 56.1 ± 15.1. Patients living in Hue was 79.9%, not living in Hue was 20.1%. Indications of EUS: in biliary diseases 37.1%, in pancreatic diseases 31.3%, in stomach 11.8%, in colon 9.0%, in esophagus 8.6%, and in duodenum 2.2%. Complications rates were very low. Lesions in gastrointestinal tract: Subepithelial lesions in stomach 57.9%, in esophagus 23.7%, in duodenum 13.6%, in colo-rectum 4.8%; cancer in colo-rectum 48.8%, in esophagus 33.2%, in stomach 16.3%, and in duodenum 1.7%. Lesions in biliary tree: gallstones 76%, common bile duct cyst 9.5%, bile duct parasitic lesions 4.3%, Vater tumor 3.8%, unknown causes biliary tract dilation 3.4% and cholangiocarcinoma 3.0%. Lesions in pancreas: chronic pancreatitis40.6%, pancreatic cancer 24.6%, acute pancreatitis 18.4%, pancreatic cyst 10.9% and lymph nodes 5.5%. EUSfine needle aspiration and EUS-guided drainage of pancreatic pseudocysts: FNA for 18 pancreatic tumors, 3 pancreatic cysts and 7 lymph nodes; drainage for 4 pancreatic pseudocysts. Conclusions: Diagnostic and interventional EUS were effectively and relatively safe in assessing lesions in alimentary tract and biliary diseases, as well as supporting to achieve samples through fine needle aspiration, and to drain pancreatic
pseudocysts.
Key words: endoscopy, endosonography
Value of the waist to height ratio in the prediction of metabolic syndrome in population of Thua Thien Hue province
Authors: Nguyen Thi Huong , Doan Phuoc Thuoc , Le Van Chi
Published: February 2023

Background: Determining the value of some predictive indices of metabolic syndrome, especially in terms of simple indices, easy implementation, non-invasive, cheap price and effectiveness, is to allow people to easily get access to those tests, simultaneously doctors at the grassroot levels can apply and implement to save costs for local people. Objectives: This study aims to identify the ability of the waist to height ratio for the identification of metabolic syndrome (MetS) in the population of Thua Thien Hue Province. Methods: A cross-sectional study was carried out with 1600 people over 25 years olds that chosen from Thua Thien Hue Province by a random sampling procedure. Metabolic syndrome was deﬁned according to the IDF, NHLBI,
AHA, WHF, IAS and IASO (2009). Receiver operator curve (ROC) analyses were used to identify the best predictor of MetS. Results: The ROC analysis revealed that had good values for predicting MetS in the Thua Thien Hue province population (the ROC curves (AUCs) > 0.8, p < 0.05). The optimal cut off values for WHtR for predicting MetS were > 0.54 for men (AUC= 0.82, sensitivity = 69.3% and specificity = 83.4%) and > 0.51 for women (AUC= 0.85, sensitivity = 76.1% and specificity = 78.8%). Conclusions: The waist to height ratio had good values for predicting MetS in population of Thua Thien Hue Province. We propose the optimal cut off point of WHtR for the best predictor of MetS as > 0.54 in men and > 0.51 in women.
Key words: prediction, the waist to height ratio
Aplicabilidade da farinha de sabugo roxo de milho e do coquetel rico em xilanase produzido pelo fungo filamentoso Fusarium sp. EA 1.3.1 em pães
Authors: Nascimento Glauce Kelly Silva , Dos Santos Tatiane Monteiro , Andressa Irene , Rodrigues Sander Moreira , Da Silva Luiz Eliel Pinheiro , Benassi Vivian Machado , Schmiele Marcio
Published: February 2023

A aplicação de fibras alimentares oriundas de coprodutos agroindustriais e matérias-primas subutilizadas tem ganhado cada vez mais espaço na panificação. Por outro lado, essas aplicações ocasionam efeitos deletérios no produto final, o que pode ser contornado com o uso de xilanases fúngicas produzidas a partir de fonte de carbono de baixo custo. Este trabalho objetivou avaliar as características de pães com adição de farinha de sabugo de milho (FS), do coquetel rico em xilanase produzido pelo fungo filamentoso Fusarium sp. EA 1.3.1 (CRX) e da xilanase comercial (XC) (17,34 U/g de farinha). A substituição parcial de 5 % da farinha de trigo (FT) por FS reduziu o volume específico (VE), altura da fatia central (AC), resiliência, coesividade e elasticidade da amostra em 12;7,4; 21,32; 11,35 e 6,30 %, em respectivo, mas aumentou a firmeza (16,8 %) e a dureza (20,26 %). A adição do CRX em conjunto com a FS (F4) não diferiu do padrão nos parâmetros de firmeza, dureza, VE e AC e apresentou valores de coesividade, elasticidade, resiliência e mastigabilidade similares ao padrão, quando comparada aos ensaios F2 (5 % FS) e F3 (5 % FS + XC). Além disso, a FS e as enzimas promoveram impactos na cor instrumental (L*, a*, b*) e apresentaram ΔE superior a 5, o que indica que pessoas não treinadas conseguem diferir as amostras com relação ao padrão. Assim, a substituição parcial da FT pela FS, associado com o CRX são promissores para a elaboração de novos produtos de panificação com adição de fibras alimentícias não convencionais ricas em xilanas.
Modelagem matemática e análise da eficiência de sistemas magnéticos ressonantes aplicados ao carregamento Wireless de veículos elétricos
Authors: Lima João Felipe Ximenes Paiva , Gomes Ian Wanderley , Gomes Cristiane Ruiz
Published: February 2023

O carregamento wireless, desenvolvido com base na aplicação direta dos circuitos magnéticos ressonantes, tem proporcionado um grande avanço no ramo dos veículos elétricos, por sua proeminência na transmissão eficiente e prática de energia durante o carregamento, tornando-se especialmente importante à medida que a sociedade se prepara para uma possível transição para veículos elétricos em detrimento dos movidos à combustão. Entretanto, muitos contratempos ainda impedem essa transição imediata. Um deles é o tempo de recarga dos automóveis, que atualmente ainda está distante de ser adequado, durando cerca de horas, e o que a implantação do carregamento wireless poderia suplantar, já que o veículo poderá carregar enquanto estiver estacionado de maneira que sua bateria estará constantemente em capacidade próxima a máxima. A eficiência desse carregamento é outro motivo gerador de discussões e de impasses para a aplicação do sistema sem fio de recarga. Porém, diferente da “indução normal” vista no carregamento de aparelhos eletrônicos como celular e tablet, o fenômeno da ressonância magnética permite que o espaço entre as bobinas seja maior e ainda assim eficiente, tornando esse tipo de carregamento equivalente ao de um tradicional, por contato físico. Assim, este artigo apresenta um modelo matemático para a análise das topologias de circuitos ressonantes de carregamento wireless, possibilitando o cálculo estimado das eficiências desses sistemas.
Cam Elyaf Takviyeli Polimer Kompozitlerin Delmesinde Takım Çapının İtme Kuvveti ve Titreşim Üzerindeki Etkisinin Araştırılması
Authors: ÖZDEMİR Burak , BAHÇE Erkan , GÜLER Mehmet Sami
Published: February 2023

Bu çalışmada, CETP (Cam Elyaf Takviyeli Polimer) kompozit malzemenin delinmesinde takım çapının oluşan itme kuvveti ve titreşim üzerine etkileri incelenmiştir. Bu amaçla CETP plaka diğer delme parametreleri sabit tutularak 5, 7,5 ve 10 mm çapında takımlarla delinmiştir. Delme süresince itme kuvveti ve titreşim ölçümü yapılmıştır. Elde edilen verilerin istatistiksel analizi sonucunda takım çapının artışı ile itme kuvvetinin arttığı ve titreşimin azaldığı görülmüştür. Ayrıca daha yüksek çaplarda takımın daha düşük salınım gösterdiği ve kararlı bir delme işlemi yaptığı tespit edilmiştir. Çalışmanın, CETP kompozit malzemelerde uygun delik kalitesini sağlayacak takım çapı seçimi için yol gösterici olması beklenmektedir. Bununla birlikte itme kuvveti ve titreşimin olumsuz etkilerini tespit noktasında araştırmacılara destek sunacaktır.
Algorithms of Ultrasound Diagnosis of Respiratory Distress Syndrome and Pneumonia in Newborns, Bronchopulmonary Dysplasia in Infants
Authors: Левандовский Е.В. , Улезко Е.А.
Published: February 2023

Было проведено ультразвуковое исследование легких у 240 новорожденных детей и детей грудного возраста с диагнозом «респираторный дистресс-синдром», «пневмония» в условиях отделения анестезиологии и реанимации (с палатами для новорожденных детей) и 98 детей раннего возраста с диагнозом «бронхолегочная дисплазия» в отделениях педиатрического профиля. Полученные данные были сопоставлены с результатами рентгенографии и компьютерной томографии органов грудной клетки. Ультразвуковой метод исследования легких позволяет диагностировать респираторный дистресс-синдром (р<0,0001; чувствительность 98,7%, специфичность 70,5%, прогностическая значимость 96,8%; AUC=0,877; коэффициент корреляции r=77; P(T<=t) двухстороннее 0,81) и пневмонии (р<0,0001; чувствительность 90,7%, специфичность 86,5%, прогностическая значимость 84,5%; AUC=0,878; коэффициент корреляции r=88; P(T<=t) двухстороннее 0,078) у новорожденных детей. Также ультразвуковой метод позволяет оценивать характер патологических изменений легких у пациентов с бронхолегочной дисплазией (р<0,00001; коэффициент детерминации R2=0,997) и прогнозировать клиническую степень тяжести (коэффициент детерминации R2=0,91). На основе полученных данных составлены алгоритмы диагностики респираторного дистресс-синдрома, пневмоний и бронхолегочной дисплазии.

Lung ultrasonography was performed in 240 newborns and infants diagnosed with respiratory distress syndrome and pneumonia in anesthesiology and intensive care units (with wards for newborns) and in 98 infants diagnosed with bronchopulmonary dysplasia in pediatric departments. The obtained data were compared with the results of chest X-ray and computed tomography. The ultrasound method of lung examination allows the diagnosis of respiratory distress syndrome (p<0.0001; sensitivity 98.7%, specificity 70.5%, positive predictive value 96.8%; AUC=0.877; correlation coefficient r=77; two-tail P(T<=t) 0.81) and pneumonia (p<0.0001; sensitivity 90.7%, specificity 86.5%, positive predictive value 84.5%; AUC=0.878; correlation coefficient r=88; two-tail P(T<=t) 0,078) in newborns. Also, ultrasound method allows to estimate the character of pathological changes of lungs in patients with bronchopulmonary dysplasia (p<0.00001; coefficient of determination R2=0.997) and predict clinical severity (coefficient of determination R2=0.91). On the basis of the obtained data, algorithms for the diagnosis of respiratory distress syndrome, pneumonia, and bronchopulmonary dysplasia were compiled.
Estrategias de marketing para la asociación artesanal Hatun Ayllukuna, Cañar, Ecuador
Authors: Acero-Zuruma Lourdes Josefina , Ordoñez-Gavilanes Magdalena Emilia
Published: February 2023

La investigación tuvo como objetivo diseñar estrategias de marketing para el posicionamiento de la Asociación Artesanal Hatun Ayllukuna, el mismo se realizó en la ruralidad del cantón Cañar-Ecuador. La investigación fue descriptiva y diseño de campo, utilizando la técnica de la encuesta, mediante un cuestionario aplicado a dos agentes informantes como socios y mercado meta. Los resultados identifican debilidades en los procesos de gestión administrativa y de marketing, se considera que un  87% del mercado meta consume cerveza, al 81% le gusta este producto de origen artesanal,  de ellos únicamente el 21%  consume cerveza artesanal, en un mercado, en el cual no se identifica fidelidad por una marca en particular, concluyendo que la organización no se encuentra posicionada a raíz de una baja aplicación e inversión en marketing, debido a una nula publicidad, desaprovechando los medios tecnológicos y las redes sociales.
Prevalence, pattern, and a leader’s intervention— The impact of alcohol abuse in police and public safety organizations
Authors: Rinkoff Paul B.
Published: February 2023

Excessive alcohol consumption among police officers and public safety professionals continues to be an organizational challenge. Alcohol abuse brings about considerable mental, physiological, and behavioural consequences for employees and their families. The severity and impact of this problem is particularly pronounced for police officers. The intent of this paper is to bring greater attention to workplace performance and health issues caused by excessive alcohol consumption. To address this challenge, leaders are encouraged to develop evidence-based policies and interventions, break down barriers caused by stigma, and prioritize the health and recovery of affected employees.
Experiencias militantes y dinámica de las organizaciones político-militares (OPM) peronistas en Santa Fe, entre 1969 y 1973
Authors:   , Raina Andrea Carla
Published: February 2023

Esta tesis se inscribe en el campo de estudios de la historia reciente situada en una escala local. La necesidad de comprender los sentidos de las experiencias militantes, el interés por ahondar en aquellas subjetividades e identidades; y la vacancia de estudios centrados en una ciudad que dio origen a muchas y muchos de ellos, representaron las motivaciones principales de la presente investigación. El tipo de abordaje nos permitió analizar y comprender las dinámicas de un actor colectivo, visibilizar tramas sociales, prácticas y particulares modos de actuar. Desde esta inscripción analítica, de perspectiva localizada, buscamos contribuir a pensar problemas más generales: ¿Cómo fue la experiencia de militantes revolucionarios de los años ‘70 desde una historia local?; ¿Quiénes eran?; ¿Qué hicieron y cómo lo hicieron?; ¿Qué sentidos tuvo esa experiencia para ellos y ellas?; ¿Cómo se identificaron?; ¿Cómo se perciben hoy? Los objetivos de la investigación versan en indagar en las experiencias concretas y en los horizontes de expectativa de las y los militantes de las organizaciones político-militares (OPM) peronistas de los años ‘70 en la ciudad de Santa Fe, capital de la provincia homónima de la República Argentina. Asimismo, estudiamos la dinámica de este actor colectivo durante el ciclo de protesta y el proceso de radicalización social y política de los años 1969 a 1973.
Kadar Flavonoid Total dan Uji In Vitro Aktivitas Tabir Surya Ekstrak Kulit Batang Tuntun Angin (Elaeocarpus floribundus Blume)
Authors: Utami Rahayu , Alpasiri Ikhsan Mauludi , Fadhli Haiyul , Ikhtiarudin Ihsan , Mora Enda , Furi Mustika
Published: February 2023

Kulit batang tuntun angin (Elaeocarpus floribundus Blume) secara tradisional digunakan untuk mengobati berbagai penyakit, diantaranya demam, radang gusi dan rematik. Penelitian sebelumnya menunjukkan bahwa ekstrak kulit batang tumbuhan ini mengandung kadar fenolik total yang signifikan. Tujuan dari penelitian ini adalah untuk mengetahui kadar flavonoid total dan memberikan gambaran awal potensi aktivitas tabir surya ekstrak n-heksana, etil asetat dan metanol kulit batang tuntun angin. Ekstraksi dilakukan dengan metode maserasi bertingkat. Penentuan kuantitatif kadar flavonoid total dinyatakan sebagai mg Quercetin Equivalent (QE)/gram ekstrak pada panjang gelombang 430 nm menggunakan alat microplate reader. Pengujian aktivitas tabir surya secara in vitro dilakukan melalui penentuan nilai Sun Protection Factor (SPF) menggunakan spektrofotometer UV-Vis. Hasil penelitian menunjukkan bahwa ekstrak n-heksana, etil asetat dan metanol mengandung kadar flavonoid total berturut-turut sebesar 9; 15,81 dan 15,56 mgQE/g ekstrak. Ekstrak etilasetat menunjukkan aktivitas tabir surya yang paling baik (proteksi ultra) dibandingkan ekstrak lainnya dengan nilai SPF 44,626; 40,687; 33,710 dan 23,607 untuk masing-masing konsentrasi uji 1000; 800; 600 dan 400 μg/mL. Namun aktivitas ini belum sebaik aktivitas senyawa pembanding benzophenone-3 pada konsentrasi 50 μg/mL dengan nilai SPF 22,646 dengan kategori proteksi ultra.
Cytotoxicity Assay of Dètente Instantanée Côntrolée Pre-Dried Pandanus conoideus Lam. Extracts
Authors: Yunita Oeke , Kohar Indrajati , Allaf Karim , Anggara Aris Sri
Published: February 2023

Red fruit (Pandanus conoideus Lam.) contains antioxidant compounds in high levels, including beta-carotene and tocopherol, which neutralize free radical compounds which can cause cancer. Red fruit contains 46% water so red fruit can only last 5 days in this condition. To maintain its stability, it is necessary to dry it with various methods, for example détente instantanée contrôlée (DIC) is a revolutionary pressure drop drying procedure. Every procedure for drying raw material can affect its quality and activity, for example the anticancer activity of red fruit. In-vitro cytotoxicity of DIC pre-dried red fruit extracts on HeLa cells has never been tested, so it is important to study. Red fruit which was obtained from Klamono, Sorong, a highland in Papua was extracted with ethanol or hexane which previously dried by DIC pre-drying or conventional drying methods were weighed then dissolved in DMSO. Cytotoxicity assays was conducted using method the MTT with five levels of extract concentration. Result of this research showed that cytotoxicity assay of red fruit extracts on HeLa cells showed that red fruit extract can inhibit cell viability. The conventionally dried red fruit extract shows stronger cytotoxicity against HeLa cells than the DIC pre-dried extract. Red fruit extract cytotoxicity against HeLa cells: ethanolic extract of red fruit previously dried by conventional drying technique > ethanolic extract of red fruit previously dried by DIC pre-drying process > hexane extract of red fruit previously dried by conventional drying method > hexane extract of red fruit previously dried by DIC pre-drying process.
OPTIMASI PENGGUNAAN ANTIMIKROBA BAGI PASIEN SEPSIS BERDASARKAN KARAKTERISTIK FARMAKOKINETIK DAN FARMAKODINAMIK OBAT: SEBUAH TINJAUAN LITERATUR
Authors: Titiesari Yovita Diane , Febriani Fany
Published: February 2023

Sepsis adalah salah satu penyebab kematian tertinggi di dunia, dan terapi antimikroba yang sesuai adalah salah satu kunci untuk meningkatkan keselamatan pasien sepsis. Patofisiologi sepsis dan penggunaan intervensi terapetik seperti renal replacement therapy akan menyebabkan perubahan farmakokinetik dan farmakodinamik antimikroba pada pasien sepsis, yang dapat menyebabkan kondisi subterapetik dan kegagalan terapi. Tinjauan literatur ini akan melihat aspek farmakokinetik dan farmakodinamik antimikroba serta perubahan aspek-aspek tersebut pada pasien sepsis dan mengaplikasikan pengetahuan ini untuk optimasi dosis antimikroba yang sering digunakan pada kondisi sepsis seperti beta-laktam, vankomisin, aminoglikosida, fluorokuinolon, tigesiklin, dan antijamur, untuk meningkatkan keselamatan pasien.
Potensi Penghambatan Sel Kanker Paru Dari Ekstrak Davallia denticulata
Authors: Hendra Rudi , Afham Muhammad , Khodijah Rohimatul
Published: February 2023

Pakis epifit yang dikenal sebagai Davalia denticulata, yang merupakan anggota dari keluarga Davalliaceae, tumbuh di kelapa sawit. Telah dilaporkan bahwa beberapa spesies berbeda dalam genus ini telah digunakan sebagai agen antikanker, agen antimikroba, dan antioksidan. Namun, belum ada laporan tentang aktivitas biologis yang terkait dengan spesies ini. Oleh karena itu, tujuan dari penelitian ini adalah untuk mengekstrak metabolit sekunder dan menguji sitotoksisitas ekstrak tersebut. Metode maserasi digunakan untuk mengekstrak tanaman ini dengan berbagai pelarut (metanol, etil asetat, dan n-heksana), dan uji MTS digunakan untuk menentukan sitotoksisitas tanaman ini dalam kaitannya dengan kanker paru-paru (cell line A549). Ekstrak menunjukkan berbagai aktivitas menghambat cell line A549. IC50 untuk aktivitas ekstrak etil asetat ditemukan sebesar 317,59 ppm, sedangkan IC50 untuk ekstrak air dan n-heksana masing-masing sebesar 575,41 dan 806,06 ppm. Pengamatan ini memungkinkan pemahaman yang lebih baik tentang sitotoksisitas spesies, yang kemudian dapat berfungsi sebagai dasar untuk penelitian lebih lanjut tentang isolasi dan bioaktivitas metabolit sekunder.

Kata kunci: Davallia denticulata, Ekstrak, Sitotoksik
Review Waktu Larut Mempengaruhi Kualitas Tablet Effervescent Sediaan Herbal
Authors: Sagala Reynelda Juliani , Rachmawati Putriana , Kambira Pretty F.A
Published: February 2023

Sediaan tablet effervescent menjadi alternatif pilihan untuk menghantarkan bahan aktif obat baik sintesis maupun yang berasal dari bahan alam agar memberikan efek terapi farmasetika maupun minuman bernutrisi di bidang pangan. Bentuk sediaan ini lebih disukai karena praktis, cepat larut dalam air dan rasa menyegarkan sehingga lebih mudah diabsorbsi dibandingkan dengan bentuk sediaan tablet konvensional. Kecepatan dan jumlah bahan aktif yang dapat diabsorbsi dipengaruhi oleh waktu larut tablet dalam medianya. Waktu larut tablet effervescent dipengaruhi oleh konsentrasi keseimbangan sumber basa dan asam, konsentrasi bahan pengikat (PVP), interaksi antara asam sitrat dan asam tartrat, konsentrasi sumber basa, kondisi kadar air di sekitar tablet, variasi bahan pelicin. Konsentrasi sumber asam mempengaruhi waktu larut tetapi ketidakseimbangan konsentrasi sumber asam dapat mengurangi efek kesegaran. Sehingga perlu optimalisasi sumber asam dan basa agar menghasilkan sediaan tablet effervescent dengan waktu larut yang baik dan memberikan rasa menyegarkan yang sesuai.

 

Kata kunci: Tablet effervescent; waktu larut; rasa menyegarkan
Uji Resistensi Nyamuk Aedes aegypty Terhadap Cypermethrin 0,05% di Bandara Sultan Syarif Kasim II Pekanbaru Tahun 2020
Authors: Handayani Dedes
Published: February 2023

ABSTRAK

Latar belakang: Penyakit tular vektor hingga kini masih menjadi masalah kesehatan masyarak at di Indonesia dengan angka kesakitan dan kematian yang cukup tinggi dan dan berpotensi menimbulkan kejadian Luar Biasa (KLB). Demam Berdarah Dengue (DBD) adalah salah satu penyakit dengan kasusnya cukup tinggi yang disebabkan oleh vektor Nyamuk Aedes aegypti. Salah satu cara pengendalian vektor Nyamuk Aedes aegypti adalah dengan menggunakan insektisida. Insektisida yang digunakan harus diketahui efikasi, keamaan serta status resistensinya. Penggunaan Cypermethrin sebagai insektisida dalam pengendalian Nyamuk Aedes aegypti di Bandara Sultan Syarif II Pekanbaru perlu diketahui status resistensinya.

Tujuan: Penelitian ini bertujuan untuk mengetahui status resistensi Nyamuk Aedes aegypti terhadap insektisida Cypermethrin di Bandara Sultan Syarif Kasim II Pekanbaru

Metode: Metode pada penelitian ini adalah deskriptif dengan desain penelitian cross sectional study. Variabel bebas adalah nyamuk Aedes aegypti yang terpapar insektisida di Bandara Sultan Syarif Kasim II Pekanbaru, sedangkan variabel terikat yaitu status resistensi Nyamuk Aedes aegypti. Metode uji resistensi mengacu pada kriteria Uji Susceptibility World Health Organization (WHO, 2013)

Hasil: Uji resistensi dengan menggunakam impregnated paper standar WHO menunjukkan persentase nyamuk yang mati setelah terpapar impregnated paper yang mengandung Cypermethrin 0,05 % setelah 24 jam di Bandara Sultan Syarif Kasim II Pekanbaru adalah 81,5%

 

Menurut WHO (2013) bila kematian Nyamuk Aedes aegypti 99% - 100% maka dikatakan nyamuk telah Rentan terhadap Cypermethrin 0,05%, bila kematian Nyamuk Aedes aegypti 80% - 98% maka dikatakan nyamuk telah Toleran terhadap Cypermethrin 0,05%, bila kematian Nyamuk Aedes aegypti < 80% maka dikatakan nyamuk telah Resisten terhadap Cypermethrin 0,05%.

Kesimpulan: Telah terjadi toleransi penggunaan Cypermethrin 0,05 % terhadap populasi Nyamuk Aedes aegypti di Bandara Sultan Syarif Kasim II Pekanbaru
Eksplorasi efek etanol terhadap survival dan status imunitas Drosophila melanogaster
Authors: Rosa Reski Amalia , Latada Nadila Pratiwi , Asbah Asbah , Mu'arif Ahmad , Yulianty Risfah , Nainu Firzan
Published: February 2023

Etanol dengan dosis yang tinggi di dalam tubuh dapat menyebabkan kerusakan pada organ termasuk otak, hati, dan ginjal. Selain itu, etanol dapat memicu terbentuknya reactive oxygen species (ROS), dimana kadar ROS yang berlebih dalam tubuh dapat menyebabkan kematian sel melalui jalur apoptosis. Sel yang tidak terfagositosis akan mengalami proses nekrosis. Pada proses nekrosis, sel melepaskan DAMPs, molekul endogen pro-inflamasi dan menginduksi sistem imun utama pada Drosophila yang homolog pada manusia yakni Toll, IMD (Immune Deficiency), dan JAK-STAT (Janus Tyrosine Kinase-Signal Transducer and Activator of Transcription). Tujuan dari penelitian ini yaitu untuk mengetahui bagaimana pengaruh paparan etanol terhadap ekspresi gen pada jalur Toll, Imd, dan JAK-STAT. Hasil penelitian menunjukkan bahwa, etanol dapat mempengaruhi tingkat kesintasan (keberlangsungan hidup) Drosophila melanogaster w1118 jantan dan betina. Paparan etanol pada konsentrasi tinggi (85%) menyebabkan penurunan ekspresi Drs, namun tidak dengan ekspresi gen Dpt. Selain itu, ekspresi gen TotA meningkat secara signifikan, namun tidak dengan ekspresi gen Upd3, seiring dengan meningkatnya konsentrasi etanol. Sebagai kesimpulan, Drosophila mengalami penurunan tingkat kesintasan akibat pemaparan etanol yang kemungkinan berhubungan dengan respon stres serta sistem imun yang diperantarai oleh jalur tertentu.
Formação de professores
Authors: Torres Josiane Pereira , Marciano Rafael Henrique de Resende
Published: February 2023

O propósito deste artigo é relatar uma experiência de uma disciplina ofertada para o ensino superior durante o período da pandemia da covid-19. O desafio dessa disciplina foi discutir as tendências para práticas didáticas mais inclusivas, disseminadas na literatura com a perspectiva de serem caracterizadas como universais, ou seja, propostas que apoiam a gestão do currículo acadêmico de modo a contemplar a diversidade da sala de aula, incluídos os considerados estudantes público-alvo da educação especial. Além de discutir essas tendências, a disciplina foi planejada nos moldes das abordagens universais, com o intuito de formar pelo exemplo. Os estudantes que cursaram demonstraram satisfação com as discussões realizadas bem como com o formato em que foi ofertada. Compreende-se que essa atividade acadêmica curricular pode apoiar o desenvolvimento de propostas similares no ensino superior de modo a contribuir com a formação de professores para a implementação de estratégias mais inclusivas na escola regular.
Novidades em Anticoagulação no Paciente Oncológico
Authors: Patrícia Lima Junqueira
Published: February 2023

O tromboembolismo venoso representa importante causa de morbimortalidade na população oncológica, com maior risco de recorrência e sangramentos. Nos últimos 20 anos, ocorreram importantes avanços no tratamento da trombose associada ao câncer, desde a demonstração da superioridade da heparina de baixo peso molecular quando comparada ao tratamento anticoagulante com antagonista da vitamina K até a incorporação de anticoagulantes orais diretos (inibidores diretos do fator Xa) a partir de 2018. Entretanto, ainda que se tenha avançado nos últimos anos, o tratamento do tromboembolismo venoso na população oncológica ainda persiste com muitos desafios e lacunas a serem preenchidas.
A Criptografia como motivação para a aprendizagem matemática
Authors: Silva Ana Lourdes Moreno Rodrigues , Perovano Ana Paula , Silva Fernando dos Santos
Published: February 2023

A criptografia está presente no cotidiano e se constitui ferramenta essencial para conferir segurança e confidencialidade na transmissão e depósito de informações, tendo como base saberes e procedimentos matemáticos. Dessa forma, considera-se que é um tema com poder de contextualizar o processo de ensino e aprendizagem e despertar o interesse dos estudantes para aprender conteúdos matemáticos. Assim, este trabalho tem por objetivo apresentar a utilização da criptografia como ferramenta para motivar a aprendizagem do conceito de função. A pesquisa, de abordagem qualitativa, foi desenvolvida com estudantes do 9º ano de uma escola pública municipal. Os dados foram coletados por meio de questionários, de observação e análise das atividades realizadas pelos discentes. O uso da Sala Aula Invertida como metodologia de ensino, somada aos recursos digitais selecionados, contribuíram para a motivação dos estudantes para realizar as atividades, apresentando suas compreensões sobre o conceito de função. Destarte, espera-se que os resultados alcançados possam servir de estímulo para práticas de ensino mais contextualizadas e significativas.
Sentiment Analysis on Jurassic Park Development in the Komodo Conservation Area
Authors: Septiana Sani Annisa , Budi Indra
Published: February 2023

Rinca Island is included in one of the islands in NTT Province, which is used as a National Park to protect Komodo dragons. According to the government's agenda, in June 2021, Rinca Island will build a world-class premium tourist destination project for tourists who want to see Komodo, which is called Jurassic Park Komodo. The existence of tourism is expected to be able to attract tourists and investment. However, the news about project development that is not in accordance with the conservation value has created public sentiment towards the project development process. The purpose of this study is to analyze public sentiment related to the classification of support & against the development of Jurassic Park in the Komodo Conservation Area and to measure the accuracy using two methods, namely Naïve Bayes and Decision Tree.
Impact of Relocating the National Capital on the Projection of Electrical Energy Consumption: a Case Study in East Kalimantan Province, Indonesia
Authors: E Setiawan Yofinda , Kusnanto Kusnanto , A Setiawan Ahmad
Published: February 2023

The availability of electrical energy is one of the crucial parameters in the growth and development of a region. To accelerate Indonesia's economic transformation and change the orientation of development to become Indonesia-centric, the government will move the current capital city to the province of East Kalimantan. Various policies have been drawn up, including the plan to relocate civil servants. The increase in population and economic mobility will have an impact on the demand for electrical energy. This research uses LEAP software, where the approach method used to calculate the projected electrical energy demand is the end-use method. There are three scenarios for projecting electricity demand, that is business as usual (BAU), moderate scenario (MOD), and optimistic scenario (OPT). MOD and OPT are scenarios with the impact of moving the national capital. The projection results for the 2022-2035 period show that the consumption of electrical energy in each scenario increases every year. The BAU scenario grew by 8.11%, the MOD scenario by 9.09%, and the OPT scenario by 9.64%. Cumulative energy consumption for all customer sectors in 2035 in the BAU scenario will reach 13,760 GWh. The MOD scenario is 15,899 GWh, and the highest energy consumption in 2035 is in the OPT scenario which reaches 17,171 GWh.
Modelling And Analysis Of Pvsc Type Buck Buck-Boost Dc-Dc Converter
Authors: Manohar Reddy Ram , Hussain Vali Shaik , Thota Phanindra , Kamaraju Kamaraju V
Published: February 2023

In the era of modern industrial development, power electronics equipment has been developed aggressively and brought dc system again in power utilization to use clean energy resources like solar array, fuel cell, wind generator, etc. Since the past decade, power electronics equipment has become very popular; hence, the switch-mode converter requirement is increasing rapidly day by day in applications like communication power supply, space crafts, hybrid electric vehicles, micro-grid and nano-grids. Among the various available configurations of converters, Multi-Input DC/DC converters became more and more popular in power electronics field, especially, for provide interface of various renewable energy sources and deliver regulated power to several loads. In this article, a PVSC type Buck Buck-Boost Dual-Input DC- DC Converter (DIDC) is designed and modelled for DC grid application. The proposed converter is driven with two renewable energy sources PV cell and a battery having different amplitudes which can able to deliver the power from source to load individually or simultaneously. DIDC tropology is simply configured with two passive elements L, C, diodes D1 D2 and switches S1 , S2. The Dual-Input DC-DC Converter suitability is validated by carrying out simulations in different modes of operation. The de-centralized PID controller is designed for voltage and current loop controller to ensure the DC output voltage of 48 V, load current of 4.8 A and power of 230W. The Stability of the closed-loop converter is also verified under all possible source and load disturbance conditions. The simulations and analysis of the proposed converter are carried out using MATLAB and PSIM software.
Predicting Startup Success, a Literature Review
Authors: Baskoro Harjo , Prabowo Harjanto , Meyliana Meyliana , Lumban Gaol Ford
Published: February 2023

The development and growth of startups around the world nowadays have become a global phenomenon. Startups have become an essential element of innovation and economic growth in many countries. But literature shows that the failure rate of a startup is around 90%. Therefore it is crucial for investors, financial advisors, and the government to spot the 10% which eventually will generate higher return rates, bring in greater revenue and ensure economic growth. This research aim is to study what are the critical factors of the startup’s success that can be used to make a predictive model using a machinelearning algorithm to predict the success of a startup.
Implementation of Edunesia Learning Media Platform Based on Mobile Ionic Typescript
Authors: Adi Guna Permana Putu , Gede Pivin Suwirmayanti Ni Luh , Surya Rahayuda I Gede , Putu Linda Santiari Ni Luh
Published: February 2023

In the era of the Internet of Things as it is today, especially in the world of education, where information can be accessed quickly, can be accessed from anywhere and anytime, it will be very helpful in the learning process and interaction between teachers and students. One method that we can apply is the existence of an application that can bridge the learning process between students and teachers, so that distance and time are no longer an obstacle, especially during this COVID-19 pandemic, such as when there is a communication PSBB between teachers and students at school. Some use Whatsapp Groups, the use of Whatsapp groups is considered less well organized, both from the material presented or the tasks given. This also supports the Industrial Revolution 4.0 where we try to prepare from an early age so that the learning process and interaction between students and teachers, apart from face-to-face, can also get used to doing distance learning. With the resources and limitations of schools, it is not an easy and cheap job to make such an application. For this reason, we dream of presenting an educational platform that can automatically initiate applications that can support today's digital learning processes or methods. Schools will be able and able to make their respective school applications easily and quickly. To answer this problem, the author tries to solve it by presenting an educational platform that can be used to create school applications independently. Edunesia platform produces applications needed for learning media or material delivery, while the applications produced by this platform include Web Admin (content manager), Teacher Android Mobile Application , and Student Android Mobile Apps. The resulting application is complete with features that support learning activities from home, such as learning videos, student and teacher consultations, Online Classrooms (Video Conference).
Kecemasan di Masa Pandemi Covid-19 Ditinjau dari Gender
Authors: Nur Irmayanti  , Agustin Ardianti , Wasil Mohammad
Published: February 2023

This study aims to determine what factors affect anxiety during the Covid-19 pandemic in terms of gender. While this research method uses a literature review method used to collect library data in the form of articles of information sources both from national and international by using database searches through mass media (online news), books, google scholars and elsevier. The results show that women are twice as likely to experience psychiatric disorders related to stress and anxiety compared to men, in this case due to several demographic factors (health, social, gender, age and economic status).
SEBACEOUS CYST : AN UNUSUAL SITE OF PRESENTATION & CASE REPORT
Authors: Meena Varchasvi , Gill Nishant
Published: February 2023

Sebaceous cysts , also known as epidermal inclusion cysts ,
are slow growing bumps under the skin that often occur on
scalp , face , ear , trunk , back or groin area .These are benign,
encapsulated subepidermal nodules lled with keratin
material however 1% of these can transform into
malignancies such as squamous cell carcinoma & basal cell
carcinoma. The term Sebaceous cyst is a misnomer since the
cyst does not involve the sebaceous glands. Sebaceous cysts
are the most common cutaneous cysts and typically occur in
rd th the 3 & 4 decades of life. These are twice as common in
males as compared to females.
A COMPARATIVE PROSPECTIVE STUDY BETWEEN STANDARD AND ALTEREDFRACTIONATED RADIOTHERAPY FOR LOCALLY ADVANCED HEAD AND NECKSQUAMOUS CELL CARCINOMA
Authors: Gaur Jalaj
Published: February 2023

Background and Purpose: To compare conventionally fractionated chemoradiotherapy (CF-CRT) with
two variants of altered fractionated radiotherapy (AFRT) in patients with locally advanced head and
neck squamous cell carcinoma (LAHNSCC). 64 patients diagnosed with LAHNSCC were randomized Material and Methods:
either to receive CF-CRT (70 Gy/35 fractions) in Arm-I or hyper-fractionation radiotherapy (HFRT 81.6 Gy/68 fractions 1.2 Gy
BID) in Arm-II or concomitant boost radiotherapy (CBT 71.6 Gy/28 fractions with last 16 fractions BID as concomitant boost) in
Arm-III. 35mg/m2 cisplatin weekly was given as concurrent chemotherapy regimen in Arm-I. The primary objective was to
assess acute toxicity, and the secondary endpoint was the radiotherapeutic response between CF-CRT and AFRT. Radiation
Therapy Oncology Group (RTOG) criteria were used for evaluating acute toxicity. Response Evaluation Criteria In Solid Tumor
1.1 (RECIST 1.1) was used to assess response. Twenty-two, 21, and 21 Results: patients were randomly assigned to Arm-I, II,
and III. The treatment was completed by 22, 17, and 18 patients in Arm-I, II, and III. The acute Grade-II skin toxicity was higher in
Arm-II (58.8%) and III (50.0%) compared to Arm-I (36.3 %), but the correlation was insignicant (p- .17). Acute Grade-III mucosal
toxicity was higher in Arm-II (35.2%) and III (38.8%), and it shows a trend towards signicance (p- .059). Arm-II had higher
complete responder (52.9%) compared to Arm-I (27.2%), and the correlation was insignicant (p- .23). The AFRT Conclusion:
arms II and III showed similar radiotherapeutic response as CF-CRT arm. Comparable acute toxicities were seen in all arms
except for the mucosal toxicity, which was higher in Arm-II and III
Hernioplastía umbilical con incisión en doble flecha: reporte de caso
Authors: Dos-Santos Jeshua , López-Castillo Ana , Domingo-del-Valle-Domínguez José , Parada-Ortiz Arturo Alfredo
Published: February 2023

La hernia umbilical en el adulto es una patología frecuente y es la segunda más común después de las hernias inguinales. Deben ser reparadas quirúrgicamente ya que pueden complicarse. Existen muchas técnicas reparativas. Este artículo presenta la reparación mediante una técnica con incisión en doble fecha y creación de neo-ombligo.
Esquisencefalia y Quiste Aracnoideo Galassi Tipo III: reporte de caso
Authors: Cano-Gutiérrez Allan , Anleu Kenny , Pérez Yusmara
Published: February 2023

Se presenta el caso de un paciente de 3 años de edad con  Esquisencefalia (ESQ) y  Quiste Aracnoideo (QA) Galassi tipo III. Estas entidades son anomalías muy poco frecuentes con una prevalencia de 0.5 a 1%. La primera es una anomalía del crecimiento neuronal y la segunda una masa benigna compuesta por colágeno, células aracnoides y líquido cefalorraquídeo. Paciente se presentó con convulsiones tónicoclónicas generalizadas con desviación de la mirada y relajación de esfínteres. Las convulsiones empezaron a los 6 meses de edad y al momento de la consulta estaba sin tratamiento farmacológico. El diagnóstico se realizó con Resonancia Magnética Nuclear Cerebral (RMN).