bluuebunny/crossref_metadata_2025 huggingface dataset:
The Staples of the State Policy as the Legal Basis for Sustainable Development to Face the Industrial Revolution 5.0 and Golden Indonesia 2045
Authors: Soesatyo Bambang
Published: January 2024

The National Long-Term Development Plan (RPJPN) and the National Medium-Term Development Plan (RPJMN) are national development planning systems developed after the abolition of the State Policy Guidelines (GBHN) in the Indonesian constitutional system. The RPJMN has been deemed inadequate because the actors that form and implement it are deemed unrepresentative and irrelevant to the essence of popular sovereignty, as well as ineffective public control mechanisms for the implementation. Therefore, a legal instrument is needed in the form of Staples of State Policy (PPHN) as a legal basis or legislative umbrella for the development and the re-establishment of the GBHN (or by other names) as well as the direction in planning and monitoring the government’s commitment as an executive institution. This research aims to find out and provide recommendations for PPHN legal basis as a legislative umbrella for implementing sustainable development in the face of the industrial revolution 5.0 and Golden Indonesia 2045. The research was conducted using normative juridical research methods with descriptive-analytical research specifications with qualitative analysis. This research applies (a) statute approach; (b) conceptual approach; and (c) comparative approach. Results show that since the reformation era, national development in terms of legislation has not been conducted sustainably. This can be seen from the disharmony and even the negation of national development programs. PPHN arrangement as Directive Principles of Indonesian Government Policies can be conducted through: (a) Limited amendments to the 1945 Constitution, especially Article 2 and Article 3 paragraph (1) of the 1945 Constitution by including the substance of the People’s Consultative Assembly (MPR) authority to formulate PPHN; (b) Amendment of Law No. 12 of 2011 by Law No. 13 of 2022 on the Second Amendment to Law No. 12 of 2011, specifically revising the explanation of Article 7 paragraph (1) letter b, hence, the MPR can formulate Decree as part of statutory regulations, including PPHN; (c) Amendment of Law No. 17 of 2014 on the MPR, DPR, DPD, and DPRD as amended several times, most recently by Law No. 13 of 2019 on the Third Amendment to Law No. 17 of 2014 by including the MPR's authority to formulate PPHN through MPR Decree; (d) Stipulation of PPHN in a law that revokes Law No. 25 of 2004 on the National Development Planning System (SPPN); or (e.) The MPR stipulates PPHN as a constitutional convention without going through changes in legal products
Implementation of Investigations and Prosecution by the Corruption Eradication Commission Based on Law of the Republic of Indonesia Number 19 of 2019 concerning the Corruption Eradication Commission
Authors: Riswadi Riswadi , Santoso Haryo
Published: January 2024

Law of the Republic of Indonesia Number 32 of 2002 concerning Broadcasting (Broadcasting Law) explains the definition of broadcasting in Article 1 paragraph (2) with the words "Broadcasting is the activity of broadcasting broadcasts through broadcasting facilities and/or transmission facilities on land, at sea or in outer space with using the radio frequency spectrum via air, cable, and/or other media to be received simultaneously by the public and the receiving device. The definition of broadcasting in the Broadcasting Law does not mention broadcasting via internet networks/infrastructure or over the top, thus broadcasting via social media platforms is still a question of whether it is subject to the Broadcasting Law or other laws. Regarding this matter, RCTI and iNews TV (MNC Group) submitted a material review to the Constitutional Court which essentially requested that the definition of broadcasting as mentioned in Article 1 paragraph (2) of the Broadcasting Law include providers of over-the-top (OTT) audiovisual services, or internet-based digital platforms such as YouTube, Instagram, or Facebook. RCTI and iNews argue that the request for judicial review of the Broadcasting Law for equality and moral responsibility of the nation is motivated by the desire to provide equal treatment and protection for all Indonesian people. Broadcasting is the activity of broadcasting broadcasts through broadcasting facilities and/or transmission facilities in the air, at sea, or in outer space using the radio frequency spectrum via air, cable, and/or other media to be received simultaneously and simultaneously by the public and broadcast receiving devices. This type of research is Normative research. The approaches used are a statutory approach and a conceptual approach. The data source used is secondary data. Data analysis was carried out descriptively and qualitatively. Concluding is carried out using a deductive method from general to specific to those related to the research issue. Legal Review of Media Broadcasting Activities in the Perspective of Law no. 32 of 2002. This research shows that if we look more closely, Law No. 32 of 2002 concerning Broadcasting has two important spirits, firstly, a broadcasting structure that is free and used solely for services to the community, not the interests of media owners. Second, the spirit of strengthening local entities which includes the spirit of regional autonomy by covering a comprehensive network system extending to the outermost areas. Broadcasting operations in several countries in the world are regulated by the laws and regulations in force in that country. Indonesia regulates broadcasting in Law Number 32 of 2002 concerning Broadcasting (Broadcasting Law).
The Influence of Financial Literacy on Village Fund Budget Absorption
Authors: Bratamanggala Rudi , Kulsum Umi
Published: January 2024

A good understanding of financial literacy will make financial planning, management, and control better. Financial literacy is the process by which individuals understand their financial situation and learn how to strengthen their finances by instilling the habit of saving, budgeting, planning, and making sound financial decisions. Not only limited to individuals, good financial literacy will also have a broad impact, for example on the absorption of village budget funds, which are provided by the government to improve existing development infrastructure in villages. This research aims to determine the effect of financial literacy on village budget absorption. This type of research uses quantitative descriptive, using regression testing via the SPSS application. The research results show that financial literacy has a significant effect on village budget absorption. The positive impact that arises is the improvement of existing infrastructure in the village so that national development can continue to move in a better direction.
The Influence of Procurement Literacy and Budget Supervision on Regional Public Health Service Agency Budget Absorption of Tugurejo Hospital
Authors: Arief Fakrulloh Zudan , Nurhayati Erni
Published: January 2024

Financial planning, management, and control will improve with a greater understanding of procurement literacy and budget monitoring. The regulations about the procurement of government goods and services are currently governed by Presidential Regulation Number 54 of 2010, with the most recent amendment being Presidential Regulation Number 16 of 2018, commonly known as the Presidential Decree on Government Procurement of Goods and Services. These regulations were formulated by the Procurement Policy Institute for Government Goods and Services, also known as LKPP. The urgent/immediate need for goods/services results in the procurement process for goods/services sometimes not complying with the provisions for procurement of goods/services. Therefore, a budget monitoring role is needed, so that budget absorption can be absorbed optimally. This research aims to determine the influence of procurement literacy and budget supervision on the absorption of the BLUD Tugurejo Hospital. This type of research uses quantitative descriptive, using regression testing via the SPSS application. The research results show that procurement literacy and budget supervision have a significant effect on the absorption of the BLUD Tugurejo Hospital. The positive impact that arises is the improvement of existing infrastructure in the village so that national development can continue to move in a better direction. In practice, the BLUD of Tugurejo Regional Hospital requires budget supervision by competent human resources so that the planned budget absorption can be realized perfectly. Competent HR means HR with a high level of financial literacy and procurement literacy
Strategi Penguatan Pendidikan Karakter Didalam Meningkatkan Semangat Belajar Anak-Anak Panti
Authors: Claudia Purba Geby , Putra Kasea Sinaga Randa
Published: January 2024

Karakter merupakan sifat-sifat kejiwaan, akhlak atau budi pekerti, tabiat dan watak yang membedakan seseorang dengan yang lain. Pendidikan karakter berkaitan dengan dimensi sosial struktural untuk menciptakan sebuah sistem sosial yang kondusif bagi pertumbuhan individu. Terbentuknya karakter memerlukan proses yang relatif lama dan terus-menerus. Strategi penguatan pendidikan karakter dilakukan melalui sikap-sikap, yaitu : keteladanan, penegakan kedisiplinan dan pembiasaan. Perlu ditanamkan didalam diri anak-anak panti adanya penguatan pendidikan karakter didalam meningkatkan semangat belajar anak-anak panti sehingga timbul adanya minat membaca buku dengan hal tersebut anak-anak panti selalu mengerjakan PR yang diberikan oleh guru dan dapat menghargai waktu dalam hal belajar. Proses penyelesaian masalah tersebut dilakukan pada kegiatan mini project PKL II dengan menggunakan metode group work pada level intervensi mezzo. Adapun tahapan yang digunakan adalah tahapan umum (General Method) sebagai berikut : Engagement, Intake & Contract, Assesment, Perencanaan/Planning, Intervensi, Evaluasi dan Terminasi. Yang menjadi fokus dari proses penyelesaian masalah klien adalah kurang adanya minat membaca buku dan jarang mengerjakan PR yang diberikan oleh guru serta kurang menghargai waktu dalam hal belajar. Tujuan dari program telah tercapai, dibuktikan melalui klien selalu rajin membaca buku setiap malam dan selalu mengerjakan PR yang diberikan oleh guru serta dapat menghargai waktu dalam hal belajar.
An Unsentimental Journey: The Letter from A. I. Tarasov-Rodionov to Petrograd Bureau of Central Committee of RCP(B) about His Trip to Siberia in the Summer of 1918
Authors:   Institute of History and Archaeology, Ural Branch of the Russian Academy of Sciences (Russia, Ekaterinburg), Weber Mikhail
Published: January 2024

The paper presents the letter from Bolshevik Alexander Ignatievich Tarasov-Rodionov, who later became a famous Soviet writer, to the top party leadership describing his journey from red Petrograd to white Tyumen and back across the front line in July — August 1918. Excluded from the party on the eve of his trip to Tyumen, Alexander Tarasov-Rodionov decided to use his trip as a way to regain the trust of party leadership by collecting and providing the latter with valuable information about the state of white rear. To this end, during his journey, he was interested in the course of hostilities, the political and economic situation in the white-occupied areas of the Volga region, the Urals and Western Siberia. The source of the information received by Tarasov-Rodionov was his own observations, materials from anti-Bolshevik newspapers and conversations with fellow travelers. The result of his observations on his return from the trip, he outlined in a detailed letter to the Petrograd Bureau of the Central Committee of the RCP(b), written on August 27, 1918. This letter is a valuable historical source on the initial period of the Civil War in the East of Russia, containing interesting information about the White terror, about everyday life in the White rear, as well as about the tactics of combat operations at the front, collected by the author at the risk of his life during his journey. To visualize the route of Tarasov-Rodionov’s journey, a schematic map was prepared, published in the appendix to the paper.
Assessment of the Influence of Natural Conditions on the Accumulation of Human Capital in the Eastern Regions of the Russian Empire in the Late 19th — Early 20th Century
Authors:   Russian Presidential Academy of National Economy and Public Administration (Russia, Moscow), Didenko Dmitry , Grishin Evgeniy ,   Institute of History and Archaeology, Ural Branch of the Russian Academy of Sciences (Ekaterinburg, Russia)
Published: January 2024

The article presents a methodology for quantitative analysis of the influence of the natural-geographical environment on the accumulation of human capital and its testing on the data from the Asian part of the Russian Empire in the late 19th — early 20th centuries. The territorial unit of analysis is an uezd or district as a set of urban and rural settlements, an internal part of larger administrative entities, namely provinces and regions. The regression analysis showed that geographical factors are statistically significantly associated with the formation of human capital in the territory of the Eastern part of late imperial Russia. The research work was carried out based on a wide range of statistical and cartographic sources, including data from the 1897 census, reference maps of the 1914 atlas, climatic atlases of the Russian Empire and others. The significance and quantitative estimates of various factors (climate, natural resources, share of the urban population, and others) of human capital accumulation depending on the sample are presented. The article shows in detail the progress of the work and its methodology, including the identification of significant factors of literacy disparity in the context of “urban/rural” and “male/female” population». Input data and results of regression analysis are provided in the corresponding tables. The processed data set was presented as a composition of cartographic materials. Thus, topical maps were prepared for the source data, in particular on natural resources and climate; statistical results on disparity were displayed in the form of cartograms.
Historical and Geographical Features of the Development of Types of Economic Regionalization of European Russia in the Late 19th – Early 20th Century
Authors:   Yaroslavl State Pedagogical University named after K.D. Ushinsky, Kondakova Tatyana ,   Institute of Geography of the RAS
Published: January 2024

The main objective of the study is to systematize little-studied and little-used experiences of economic regionalization based on the study of primary sources of the pre-revolutionary period (from the mid-19th to the early 20th centuries). The article identifies the features of the formation and evolution of types of economic regionalization during this period based on the analysis of historical statistical sources; a grouping of economic zoning experiences is given: private zoning, complex economic expert zoning, agricultural statistical zoning; for each group, main and auxiliary characteristics and indicators for identifying and defining areas are established; the characteristics of examples of agricultural zoning in chronological order are given in more detail; in private zoning, the division of provinces into districts is considered based on the principles of fertility and the size of the land plot per 1 male soul. When characterizing the types of complex economic zoning, the most well-known, along with little-known, types of economic zoning are shown, including industrial zoning, supplemented by division into districts based on the grouping of distilleries, by the volume of handicraft wood processing, by the volume of match production; the importance of using these indicators is shown. When characterizing agricultural zoning, the importance of statistical indicators for identifying and defining regions is shown. Experiences of comprehensive economic and agricultural zoning are systematized on a chronological basis.
Ceramic Complex from the Excavations of the Gilevs Estate at the Intersection of Pushkin and Pervomaiskaya Streets in Ekaterinburg: A Technical and Typological Analysis and Morphology of the 19th - Early 20th Centuries Crockery
Authors:   Institute of History and Archaeology, Ural Branch of the RAS (Russia, Ekaterinburg), Bulakova Ekaterina , Vasina Yulia ,   South Ural State University (national research university) (Russia, Chelyabinsk), Trofimova Ekaterina ,   Center for Historical and Cultural Research "Astra" (Russia, Ekaterinburg)
Published: January 2024

The article presents the results of a technical, typological and morphological analysis of a ceramic complex (crockery) obtained during excavations of a site of the cultural layer of the modern era (19th — early 20th centuries) within Pushkin - Pervomaiskaya - Tolmacheva streets in Ekaterinburg, which is the courtyard of the Gilevs burgher estate. It provides a detailed description of the stages of formation of the site itself and a biography of the inhabitants of the house from 1810/15 to 1912, as well as some data from archaeological work, a significant part of which is the analysis of the clothing complex. Dealing with such type of archaeological source, as archaeological ceramics, is of particular interest due to the limited data in written sources about the types and places of pottery production in Ekaterinburg from the late 18th to early 19th centuries. Describing and identifying the types of ceramics obtained, firstly, allows determining the crockery types and starting creation of a typology of the 19th — early 20th centuries dishes, used in everyday life by residents of the estate, and more broadly, the city. And, secondly, it allows combination and comprehensive analysis of data from written and archaeological sources. For Ekaterinburg, such work based on archaeological sources is relevant and interesting; it is presented in an expanded format for the first time.
Association Between Anemia and Clinical Outcome in Acute Ischemic Stroke Patients Treated With Endovascular Treatment
Authors: Ceulemans Angelique , Pinckaers Florentina M.E. , Postma Alida A. , van Zwam Wim H. , van Oostenbrugge Robert J.
Published: January 2024

Background and Purpose Endovascular treatment (EVT) is the preferred treatment option in eligible acute ischemic stroke (AIS) patients with a large vessel occlusion of the anterior circulation. Several comorbidities have been identified that can affect clinical outcomes. Various studies have investigated the association between anemia and clinical outcome and found conflicting results. The aim is to investigate the association between pre-EVT anemia and clinical outcomes at different time points post-EVT, primarily focusing on the National Institutes of Health Stroke Scale (NIHSS) at 24–48 hours.Methods We prospectively included 560 AIS patients who received EVT in the Maastricht University Medical Center+. Hemoglobin levels (Hb; g/dL) were determined on admission. Hb levels were also categorized into two groups: anemia (male: Hb ≤12.9 g/dL; female: Hb ≤11.9 g/dL) and no anemia. Multiple imputation was used to handle missing data. Multivariable regression was used to investigate the association between anemia or Hb levels and clinical outcomes.Results Anemia was present in 26% of the patients. Multivariable regression did not show a significant association between anemia or Hb levels and NIHSS at 24–48 hours (adjusted β [aβ]anemia: 1.44, 95% confidence interval [CI]: -0.47 to 3.36; aβHb: -0.37, 95% CI: -0.88 to 0.13). However, multivariable regression showed significant associations with modified Rankin Scale (adjusted common odds ratio [acOR]anemia: 1.66, 95% CI: 1.12 to 2.48; acORHb: 0.83, 95% CI: 0.75 to 0.93) and poor functional outcome at 90 days (adjusted OR [aOR]anemia: 2.09, 95% CI: 1.21 to 3.63; aORHb: 0.80, 95% CI: 0.69 to 0.92).Conclusion Anemia was not independently associated with early neurological deficit (NIHSS) post-AIS, suggesting it is more suitable as a general frailty marker.
Design and Building of an Automatic Water Filling System on Water Container Media Based on Arduino Esp8266
Authors: Pradana Alfazri Putra , Aminudin Nur , Rizki Fahlul , Feriyanto Dwi
Published: January 2024

In the era of rapidly developing technology, innovation is important to facilitate human life. Water is the main need for all living things, especially humans, so it needs to be managed efficiently. Water filling in reservoirs is usually still done manually, which can cause a waste of clean water. Manual water filling requires humans to control the pump as needed. However, it often happens to forget to turn off the pump after the reservoir is full, which can cause a waste of water and electrical energy. To solve this problem, the idea is to make an automatic system with Arduino ESP 8266 called "Design of Automatic Water Filling System on Arduino ESP 8266 Based Water Reservoir". This system uses ultrasonic sensors to measure the water level in the reservoir. When the water reaches a certain level, the system will activate the water filling, and the user can monitor the water level in real time through a mobile device. This research aims to design and test this automatic water replenishment system to avoid water waste. The result is expected to be an efficient solution better than the manual system and beneficial in clean water management. This research will answer important questions about this system's design, workings, and test results. The main conclusion of this research is the need for improvements in the design and implementation of automatic water filling systems. Further analysis, adjustments, and retesting are needed to overcome the obstacles encountered.
GESPLAN: desarrollo e implantación de un cuadro de mandos de gestión y planificación enfermera
Authors: Alda Clavero Inmaculada , Lucas Giménez Celia , García-Minguillan Castillo María del Carmen , Climent Amorós María Teresa , Pérez Sánchez Ana Valeria , Solaz García Álvaro
Published: January 2024

Objetivo principal: Elaborar e implementar un software de gestión y planificación de cuidados. Metodología: Se ha llevado a cabo el desarrollo de un software basado en el acceso a los datos en tiempo real de los diferentes sistemas de información clínica. Se definieron 4 fases: diseño y desarrollo del prototipo, prueba de concepto, implantación y evaluación. Resultados principales: Este software ha permitido integrar los diversos sistemas de información e historia clínica electrónica dando lugar a una herramienta que permite optimizar la gestión y planificación enfermera en tiempo real. Mediante la minería de procesos e inteligencia artificial permite generar alertas e indicadores para optimizar la gestión de las unidades de hospitalización. Conclusión principal: El desarrollo del software ha permitido unificar los sistemas de información y ser una herramienta para facilitar la toma de decisiones y la planificación organizativa de los mandos enfermeros tanto de las unidades como de la dirección.
Alfabetización en salud de la población, un pilar para la atención centrada en el paciente
Authors: Duque González Bárbara Pilar
Published: January 2024

Objetivo principal:  Conocer el nivel de alfabetización en salud de la población menorquina. Metodología: Se plantea un estudio descriptivo a través del cuestionario de alfabetización en salud HLS-EU-Q16 en versión traducida al español. Resultados principales: Establecimiento de estrategias por franjas etarias en función del resultado del estudio. Conclusión principal: Conocer el nivel de alfabetización de la población nos ofrece la oportunidad de mejorar la comunicación entre los profesionales sanitarios y los usuarios y establecer estrategias adecuadas para mejorar la educación para la salud.
Persepsi Masyarakat Desa Lakardowo Terhadap Pencemaran Limbah B3 PT. PRIA pada Pertanian, SDA, dan Kesehatan
Authors: Putri Amara Cindradewi Anton
Published: January 2024

Tahun 2010 berdiri Pabrik PT. PRIA di Desa Lakardowo yang menyebabkan pencemaran limbah B3. Limbah B3 adalah zat, energi, atau komponen yang karena sifat, konsentrasi, atau jumlahnya dapat mencemarkan, merusak, membahayakan lingkungan hidup, kesehatan, kelangsungan hidup manusia dan makhluk hidup lain. Tujuan penelitian untuk melihat persepsi masyarakat tentang pencemaran limbah B3 dalam pertanian, SDA, dan kesehatan. Penelitian ini menggunakan kuesioner, wawancara, observasi, dan metode analisis hasil menggunakan deskriptif. Hasil penelitian menunjukkan bahwa sebelum dan sesudah berdirinya PT. PRIA ada perbedaan mulai pertumbuhan tanaman, hasil produksi, kualitas air, kualitas udara, kualitas tanah, dan pendapatan. 71% responden pernah terkena penyakit gatal, 49% responden pernah terkena sesak napas, dan 24% responden pernah terkena iritasi mata. Dampak sosial yang dirasakan yaitu kurang rukunnya dengan tetangga atau saudara. Pada uji regresi sederhana dengan alat bantu SPSS 25.0 didapatkan nilai Sig (0,000) < nilai α (0,05), berarti ada pengaruh positif signifikan pertumbuhan tanaman terhadap hasil produksi.
Penerapan Metode Role Playing Dalam Meningkatkan Hasil Belajar Peserta Didik Pada Mata Pelajaran Bahasa Indonesia
Authors: Dwi Putri Pramesti Ginna Novarianti
Published: January 2024

Dalam konteks pembelajaran, guru juga perlu pandai memanfaatkan sarana dan prasarana yang dapat mendukung kegiatan proses pembelajaran sesuai harapan. Penelitian ini bertujuan untuk meningkatkan motivasi dan hasil belajar Bahasa Indonesia siswa kelas IV SD Negeri Lemah Abang melalui penerapan Metode Pembelajaran Role Playing pada materi Bersikap Santun. Penelitian ini menggunakan penelitian tindakan kelas. Subjek penelitian adalah siswa kelas IV SD Negeri Lemah Abang yang berjumlah 35 siswa. penelitian terdiri dari dua siklus masing-masing siklus meliputi perencanaan, pelaksanaan, observasi dan refleksi. Pengumpulan data dilakukan bersama dengan pelaksanaan penelitian pada saat proses pembelajaran. Pelaku pengumpulan data adalah peneliti dan teman sejawat yang bertugas sebagai observerr. Berdasarkan hasil penelitian disimpulkan bahwa penerapan strategi pembelajaran Role Playing pada materi Bersikap Santun dapat meningkatkan hasil belajar siswa kelas IV SD Negeri Lemah Abang. Hal ini dapat dibuktikan dengan keaktifan dan semangat siswa serta hasil belajar yang meningkat. Dalam target Penelitian ini adalah mencapai 80% dari jumlah siswa. untuk memperjelas mengenai data ketuntasan belajar. Ketuntasan pada pra-siklus hanya mencapai 50%, kemudian pada siklus 1 ada sedikit peningkatan 65%. Sedangkan pada siklus 2 kembali meningkat mencapai Angka 100%. Artinya dalam penelitian ini sudah melebihi target yang telah ditetapkan, yakni 80%.
Gordon Research Conference & Student/Postdoc Conference on Unifying Ecology Across Scales
Authors: White Ethan
Published: January 2024

If you’re interested in big ecological datasets, natural history, ecological forecasting, and predictive cross-scale ecology (like we are) then you should check out the upcoming Gordon Research Conference (GRC) on Unifying Ecology Across Scales (July 28 – Aug 2) and the associated Gordon Research Seminar (GRS; July 27-28; a student/postdoc only conference that occurs before the larger conference).
Educación emocional en el Perú. Una revisión sistemática
Authors: Valdivieso Palavicini Miguel Ángel
Published: January 2024

El objetivo de esta investigación fue realizar una revisión de la literatura publicada en el período 2018-2023 sobre la educación emocional. La metodología empleada fue la revisión sistemática de la literatura científica relacionada con la educación emocional en las bases de datos Scopus, Web of Sciences, Scielo, Latindex y Dialnet. Se aplicó la guía Prisma para la selección de estudios y Strobe para evaluar la calidad editorial y metodológica. En la búsqueda inicial se identificaron 380 artículos científicos de los cuales se tamizaron 135 que incluyeron la variable educación emocional en título o resumen, con base en la aplicación de criterios de inclusión y exclusión se meta-analizaron 12 publicaciones científicas. La mitad de ellos entre los años 2020-2021, publicados en su mayoría en España (50%) y Chile (16,67%), seguido de Cuba (8,33%), Ecuador (8,33%), México (8,33%) y USA (8,33%). Todos los estudios se desarrollaron en instituciones públicas. La mayor parte de los artículos fueron publicados en revistas indexadas en la base de datos Scopus (41,67%), el 25% en Latindex, otro 16,67% en Dialnet, Web of Sciences (8,33%) y Scielo (8,33%).
Estrategias para desarrollar la creatividad en los docentes: Una revisión bibliográfica
Authors: Rodríguez Juárez Norma Daisy , García Vera Oscar Ysidro
Published: January 2024

La pandemia por la COVID-19 encamino a diversos cambios a nivel global, entre estos, la educación afronta uno de los principales desafíos, lo cual es asumido principalmente por el grupo docente, en esta perspectiva, la creatividad se posicionó como el atributo de mayor relevancia para que el educador logre cumplir con efectividad la actividad de enseñanza a favor del aprendizaje eficiente del alumnado. Por tanto, el estudio planteo como objetivo el revisar las estrategias para desarrollar la creatividad en docentes, encontrando principalmente cinco la proactividad, la estrategia analítica, de planificación, la reguladora y la progresista, como el grupo que permite el adecuado funcionamiento creativo del docente y por tanto su desarrollo profesional.
KLIKHIU: APLIKASI PENDUKUNG PEMASARAN DENGAN STRATEGI JARINGAN DAN STANDARISASI HARGA
Authors: Kuswardayan Imam , Herumurti Darlis , Yuniarti Anny , Fabroyir Hadziq , Arifiani Siska
Published: January 2024

Harga produk di platform online seringkali berada di bawah standar. Hal ini terjadi karena beberapa faktor, seperti persaingan yang tinggi diantara sesama penjual, biaya operasional sistem penjualan dengan platform online yang rendah, serta kurangnya pengawasan terhadap kualitas produk. Dalam beberapa kasus, penjual mungkin menjual produk dengan harga yang lebih rendah dari harga pasar untuk menarik pelanggan. Namun, harga yang terlalu rendah dapat menimbulkan kecurigaan terhadap kualitas produk. Selain itu, biaya operasional yang rendah dapat mengurangi kualitas layanan dan pengiriman produk. Oleh karena itu, untuk menjaga kesejahteraan pelaku usaha dalam ekosistem perdagangan digital yang semakin berkembang, dikembangkan sebuah aplikasi yang dapat memastikan bahwa produk perusahaan dapat dipasarkan dengan harga yang sesuai standar yang berlaku. Aplikasi yang dikembangkan, KlikHIU, memiliki fitur utama yang dapat mencegah penjual menetapkan harga jual produk yang dipasarkannya di bawah harga standar. Hal ini bertujuan untuk memastikan persaingan yang sehat antara penjual. Aplikasi KlikHIU juga dapat menghubungkan penjual dengan jaringan distribusi. Dengan aplikasi KlikHIU yang dikembangkan, perusahaan dapat memberikan kepastian kepada konsumen tentang harga dan kualitas produk yang mereka beli.
La experiencia de co-construcción del Taller 'Testimonios de desplazamiento y migración: del gesto a la reparación'
Authors: Parra Grondona Agustín , Celmy Castro Aura
Published: January 2024

Este artículo aborda el proceso de construcción conjunta del taller Testimonios de desplazamiento y migración: del gesto a la reparación que realizaron dos organizaciones de Medellín, Colombia: el programa La paz es una obra de arte de la Facultad de Artes de la Universidad de Antioquia y el colectivo teatral Piel Adentro perteneciente a la Ruta Pacífica de las Mujeres. Desarrollado en el contexto del proyecto TransMigrARTS, evidencia cómo la co-creación, co-participación y co-implementación del dispositivo taller artístico permite un diálogo horizontal entre la academia y una organización cultural que pertenece al mismo grupo poblacional sobre el que se quiere incidir positivamente, lo que amplia los alcances y la profundidad de los procesos de transformación personal y social de las participantes, así como del mismo colectivo Piel Adentro. Aunado a la incorporación de una fase de introspección a la estructura del taller, este dispositivo ensancha el horizonte de posibilidad de la investigación creación aplicada orientada a la disminución de vulnerabilidades y al fortalecimiento de capacidades entre la población migrante.
Dupla experiencial · Sentires como relatoras del grupo de evaluación
Authors: Patiño Castañeda Yazmín Andrea , Lemus Gómez Lia Esther
Published: January 2024

Estos escritos son producto de un tejido construido desde el encuentro, un entrelazamiento de ideas y palabras que fueron inspiradas a partir de la invitación de Félix Gómez-Urda, quien dispuso su experiencia como guía para animarnos a escribir desde la disciplina y la libertad. Disciplina en tanto la escritura requiere atravesar marcos en los que la mente y el cuerpo se disponen, ha sido escuchar la palabra, escribirla y leerla nuevamente para permitir que vaya tomando forma.
Development of Mitophagy-inducing Small Molecules as Therapeutics for Aging and Alzheimer's Disease
Authors:   University of Southern California, Buck Institute for Age Research, Andersen Julie
Published: January 2024

Alzheimer's disease (AD) is the leading cause of dementia in those over the age of65. The underlying molecular basis for the disease remains elusive. Rather than simply viewing individual diseases in isolation, researchers have turned to studying the contribution of common age-related processes. One such process is loss in mitochondrial function, normally maintained by defective mitochondrial clearance via mitophagy. Mitophagy slows with age and with various age-related conditions including AD. An agent which has received considerable attention is urolithin A (UA) which has recently been reported to elicit neuroprotection in a variety of AD models. As part of an independent small molecule screen, we identified a second structurally-related compound we named ‘mitophagy inducing compound’ (MIC). Using C. elegans as an initial validation tool, we showed that both compounds significantly improve mitochondrial function, protect against neuronal cell loss, and extend lifespan. These effects were translatable to both in vitro and in vivo mammalian models. To identify potential drug targets, we performed Cellular Thermal Shift Assay (CETSA). Preliminary data from knockdown of identified targets suggest the involvement of a mito-hormetic mechanism which acts to restore overall mitochondrial health. These studies may have important implications for how these compounds elicit their effects.
The AD Exposome
Authors:   Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA, Finch Caleb E.
Published: January 2024

Efforts to find human genes for Alzheimer Disease and for longevity have generally neglected environmental influences. Brain aging and ADRDA may be understood in the AD Exposome framework, which includes external and endogenous interactions from embryo to old age (Finch and Kulminski 2019; Finch and Haghani 2021). Environmental factors in brain aging and longevity are as strong as common aging genes illustrated by the 15-year difference in the onset of dementia across SES (Finch 2023). Gene-environment interactions merit further attention.
Uncovering Rules to Sustain Neurons' Long Lives: Signaling Redundancy and Resiliency at the Onset of Neurodegenerative Disease
Authors:   Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, New Orleans, LA 70122, USA, Bazan Nicolas ,   Neuroscience Karolinska Institutet, Stockholm, Sweden
Published: January 2024

Our laboratory has been experimentally asking if there is a molecular logic that sustains neuronal survival as the brain is confronted with onset and/ or progression of neurodegenerations. We found that under imminent homeostasis disturbance, the brain activates the production of mediators of cell integrity and function, which includes the elovanoids (ELVs). They are formed from very long-chain polyunsaturated fatty acids (C 32-34) synthesized by neuronal-specific ELOVL4. Mutations of the gene that encodes this enzyme cause, among other pathologies, vision loss, seizures, and mental retardation. ELVs protect neurons by upregulating pro-survival and downregulating pro-apoptotic protein abundance. Also, ELVs enhance deacetylase Sirtuin 1, which modulates longevity signaling; E3 ubiquitin ligase (Iduna), and transcriptional regulator Prohibitin type 2. The ELV synthesis pathways are downregulated in Alzheimer’s models and in specific retinal cells of age-related macular degeneration patients. Using limited proteolysis/MS, we found that ELV-N34 selectively modulates TNXRD1 (from thioredoxin, an NADPH/FAD redox- effector that sustains homeostasis) underling its protection.
Breakthroughs in Alzheimer’s Disease Drug Development
Authors:   CXPT, USC Mann School of Pharmacy & Pharmaceutical Sciences, PSC 504, 1985 Zonal Ave. Los Angeles, California 90089, Liang Jing
Published: January 2024

Alzheimer's disease (AD) is a neurodegenerative condition characterized by cognitive decline and memory loss. The current lack of understanding regarding the cause of AD has impeded the development of animal models for drug testing, resulting in a dearth of effective prevention and treatment methods. Despite efforts to target Aβ plaques and tau protein tangles, which have proven ineffective, it is evident that these factors alone do not fully account for the cognitive deficits and memory loss associated with AD. While clinical trials seek effective treatments, success remains uncertain.
Mitochondrial Dysfunction and Mitochondrial Cascades in Alzheimer's Disease
Authors:   University of Kansas Medical Center, Swerdlow Russell H.
Published: January 2024

Energy metabolism maintains energy homeostasis at subcellular, cellular, organ, and whole organism levels. System failures, which may arise at or within mitochondria, adversely affect health and viability and associate with Alzheimer’s disease (AD). Understanding the origins, causes, and consequences of AD energy metabolism, bioenergetic, or mitochondrial dysfunction can help identify therapeutic targets and guide treatment design. Interventions designed and intended to manipulate energy metabolism, bioenergetic function, and mitochondria increasingly are appearing and their development is playing out at basic, translational, and clinical levels. This presentation will review evolving views of energy metabolism’s role in AD; potential therapeutic strategies for AD; and general challenges faced by this emerging field.
Single-cell Spatial Transcriptomics Analysis of Alzheimer's Disease Pathogenesis in Mouse Models
Authors:   University of California Irvine, CA, Xu Xiangmin ,   Center for Neural Circuit Mapping
Published: January 2024

Understanding molecular mechanisms of Alzheimer’s disease (AD) has proven challenging as disease effects occur at multiple scales in different brain regions. We apply multiplexed error-robust fluorescence in situ hybridization (MERFISH) to generate spatially resolved single-cell RNA atlases from multiple cortical and subcortical brain regions in 5xFAD and age-matched C57 wild-type mice. We also investigate the effect of the TREM2R47H mutation, a strong risk factor for the development of AD in humans, producing similar atlases for Trem2R47H and Trem2R47H-5xFAD mice. We identify amyloid- beta plaque proximal molecular alterations in microglia and astrocytes, but also in five neuronal cell types. Spatial analysis of microglia and astrocyte concentrations reveals Trem2R47H -dependent regional variations, as well as regional transcriptional variation independent of either 5xFAD or Trem2R47H mutations. Cortical excitatory neurons exhibit a consistent Trem2R47H -induced expression increase in Ntrk2, and other MAPK signaling- associated genes, and thalamic excitatory neurons exhibit both 5xFAD and Trem2R47H induced gene program alterations. Additionally, nearly every neuronal cell type exhibits subclusters with decreased 5xFAD populations. Taken together, our MERFISH analysis of 5xFAD and Trem2R47H Alzheimer’s mouse models reveals spatially localized, cell-type-specific, plaque and Trem2R47H induced transcriptome dysregulations in cortical and subcortical brain regions.
Modeling Late-Onset Alzheimer's Disease in Mice
Authors:   University of California, Irvine, LaFerla Frank
Published: January 2024

As part of our participation in the Model-AD consortium, the UCI group has developed at least 12 novel mouse models that are relevant to studying the mechanisms underlying late-onset Alzheimer's disease (LOAD). These new models include variants in Abca7, Clu, Picalm, and Trem2. Modeling LOAD is hampered by the subtle effects imparted by the GWAS variants versus the much stronger phenotypic effects imparted by autosomal dominant AD mutations. We have successfully built a platform mouse in which the Aβ sequence has been humanized, and we found that wildtype-hAβ is sufficient to induce synaptic deficits and loss and accelerate the formation of astrocyte-associated Periodic Acid Schiff granules, normally associated with aging. We are actively introducing human tau alleles into these platform mice. Our strategy is to couple the humanizing of critical AD genes (APP, tau) with GWAS variants (Abca7, Clu, Picalm,) to better assess the impact that these alleles have on the phenotype. Modeling late-onset Alzheimer's disease represents a significant challenge, but success will likely yield substantial insights into disease mechanisms and advance drug discovery and evaluation efforts.
The Purely Thermodynamic Anti-prionic Mode of Action for the Treatment of Neurodegenerative Diseases
Authors:   Institute of Biological Information Processing (IBI-7), Forschungszentrum Jülich, Jülich, Germany, Willbold Dieter
Published: January 2024

Neurodegenerative protein-misfolding diseases, like Alzheimer’s (AD) and Parkinson’s disease (PD), are driven by prion-like self-replicating and propagating protein assemblies of amyloid β (Aβ), α-synuclein, and many more. The conformation these proteins have in the aggregated state is thermodynamically more stable than their physiological monomer conformation, which is often intrinsically disordered. Therefore, we have developed all-D-enantiomeric peptide ligands that bind the monomeric protein of interest with high affinity, thereby stabilizing the physiological intrinsically disordered monomer structure. These ligands are eliminating already existing aggregates by disassembling them into monomers. This purely thermodynamic driven mode of action (MoA) is truly “anti-prionic”, because it is eliminating already existing oligomers and fibrils, thus disrupting prion-like replication and propagation of toxic protein aggregates. The MoA is realized by all-D-enantiomeric peptides that are specific for the target protein.
Chronic Alzheimer's Disease (Ad) Patients Show Safe, Significant, and Persistent Benefit in 10 Month Bryostatin Trial
Authors:   Synaptogenix, Inc., Alkon Daniel
Published: January 2024

During the past century, since the discovery of the neurodegenerative disease that was first described by Dr. Alois Alzheimer, widespread efforts have focused on the etiology, diagnosis, prevention, and effective treatment of Alzheimer’s disease (AD). Although many insights have been generated, no therapeutics have ever been identified that might lead to treating the underlying progression of this devastating, ultimately fatal dementia.
Targeting Dysregulated Neuroinflammation in CNS Disorders
Authors:   Sanders-Brown Center on Aging, Van Eldik Linda J. ,   University of Kentucky Alzheimer's Disease Research Center
Published: January 2024

A critical mechanism driving neurodegenerative disease progression is dysregulated brain inflammation. Neuroinflammatory repair processes are fundamental to CNS homeostasis, but inflammation that is inefficient, excessive, or prolonged can contribute to neurodegeneration. A specific aspect of neuroinflammation, stressor-induced proinflammatory cytokine overproduction from abnormally activated glia, has been linked to subsequent neurological damage and cognitive deficits in both acute and chronic CNS disorders. This cytokine/synaptic dysfunction axis (Fig. 1) has emerged as an attractive druggable target for neurodegenerative diseases. However, despite advances in our understanding of these molecular neuroinflammatory mechanisms, approved therapeutics that target this pathological process are lacking. To address this need, we used an integrated, recursive drug discovery platform (Fig. 2) to develop brain-penetrant, small molecule drug candidates that normalize cytokine levels and exhibit efficacy at low doses in multiple animal models of CNS disorders. The molecule design stage began with a pyridazine chemotype that was diversified using established chemistries to create a library of compounds. Compounds were screened for concentration dependence and selectivity using either a single molecular target approach or the historically successful functional/pathway-based approach. A pharmacology assessment stage was incorporated to assess compounds for drug-like properties, such as chemical and metabolic stability, CNS penetrance, and potential for safety. Prioritized compounds were then tested in relevant animal models, and the most promising drug candidates taken into formal IND-enabling preclinical testing. The platform yielded three clinical drug candidates, MW150, MW151, and MW189, that are all in human phase 1b/2a clinical trials.
The Gut Microbiome Alterations and Inflammation-driven Pathogenesis of Alzheimer's Disease
Authors:   Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland, Leszek Jerzy
Published: January 2024

Recent scientific discoveries underscore the vital role of the gut microbiota in bidirectional communication with the brain, suggesting that the human gut microbiota may serve as a “second brain” with implications for neurodegenerative disorders like Alzheimer’s Disease (AD). Although human-associated microbial communities are generally stable, common activities, such as antibiotics and high-fat diets, can disrupt them persistently. These enteric bacteria, encompassing commensal and pathogenic microorganisms, significantly influence immune function, brain development, and behavior. They can produce neurotransmitters, neuromodulators, and amyloids. Brain damage mechanisms leading to dementia and AD start with dysbiosis in the intestinal microbiome, causing local and systemic inflammation and disrupting the gut-brain axis. This heightened gut permeability allows various bacteria, viruses, and their neuroactive products, like toxic proteins and inflammatory molecules, to invade. The inflammatory-infectious hypothesis of AD, emphasizing the role of the gut microbiome, gains traction over the longstanding amyloid cascade hypothesis. In conclusion, AD’s origin in the gut and its close link to gut microbiota imbalance present a promising avenue for therapeutic intervention. Modulating gut microbiota through personalized diets or beneficial microbiota interventions to alter microbial partners and their products, including amyloid protein, may emerge as a novel AD treatment.