bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigación en diseño. Discusiones contemporáneas sobre sus oportunidades y desafíos
Authors: Sánchez de Carmona y Lerdo de Tejada Manuel Ángel , de la Torre Galindo Francisco Javier , Bernárdez de la Granja María del Carmen , Martínez Herrera María Teresa Guadalupe , Flores Gutiérrez Avatar , Paniagua Ramírez Karla , Camacho Rojas Jorge Arturo , Canto Chac Saturnino Manuel , Azamar Alonso Aleida , Saldaña Vázquez Romeo Alberto , Hernández Trejo Felipe de Jesús , Acero Campos Gerardo , Ramírez Islas Vania Sarahí , Ochoa Heredia Daniela Guadalupe , Morales Moreno Andrea , López Zuppa Martha , López Pérez Blanca Estela , Ramírez Lozano Alejandro , Gallardo López María Lizbeth
Published: December 2024

Libro que surge como resultado del primer Seminario de los Posgrados en Diseño, realizado en agosto y noviembre de 2023, la obra es un insumo en ese proceso de autorreconocimiento crítico y propositivo de los Posgrados en Diseño, es, de manera general, un diálogo entre los conferencistas y la comunidad, y al mismo tiempo, un posicionamiento epistemológico que afirma la imposibilidad de (re)pensar de manera endógena, improvisada y desconectada, por lo que es imperativo tomar riesgos disciplinares que borren las fronteras del conocimiento y se atrevan al diálogo entre la filosofía, la ciencia, la creatividad, la proyección, así como entre las posturas, miradas y formas, es además de lo anterior, una propuesta ecléctica por convicción. La obra se compone de tres secciones: en la primera se presentan dos capítulos que ofrecen perspectivas sobre la investigación en Diseño desde la arquitectura y la comunicación; la segunda parte la integran otros tres capítulos que discuten el papel del enfoque de Diseño ante grandes problemas locales y nacionales, desde la ciencia política, la economía y la ecología; por último, la tercera parte presenta una serie de relatorías de las seis conferencias presentadas en el Seminario de los Posgrados en Diseño 2023.
A responsabilidade penal pelos maus-tratos aos animais
Authors: Pegorini Regina , Gehelen Maristela Heinen
Published: December 2024

A proteção animal vem sendo violada há séculos diante da negligência humana em cessar os atos de crueldade contra os animais e da ineficácia das normas existentes para protegê-los. Trata-se de pesquisa de revisão bibliográfica num sentido amplo, com o uso de periódicos, livros, dissertações, teses e artigos de website, para garantir a segurança jurídica e a concretização do direito fundamental à vida e dignidade dos animais, amparados por valores e regras presentes na Legislação Pátria. Torna-se essencial a compreensão do direito dentro de uma problemática tão grandiosa como é a proteção animal na atualidade. O presente artigo tem como objetivo geral descrever os tipos de crueldade cometidas contra os animais e destaca a aplicação ineficaz do art. 32 da Lei 9.605/98, principal mecanismo legal para penalizar os responsáveis por maus-tratos. Explorou-se a perspectiva doutrinária emergente, que agora reconhece os animais como sujeitos de direitos, apesar de ainda serem categorizados como propriedades pelo Código Civil. Este tema destaca a urgência de reconhecer os direitos dos animais, considerando sua condição como seres vivos com sensações físicas e emocionais. Além disso, enfatiza a necessidade imperativa de assegurar proteção e cuidados para garantir o bem-estar animal, em paralelo aos direitos humanos. Em última análise, a pesquisa busca promover o respeito pelos animais e defender o direito fundamental à vida, intrínseco a todas as formas de existência.
O constitucionalismo abusivo perante a democracia
Authors: Rodrigues Ketlin Cristina , Borges Eduardo
Published: December 2024

O presente artigo através de pesquisa bibliográfica e jurisprudencial busca analisar o constitucionalismo abusivo e os impactos causados na democracia. Esse fenômeno se perpetua através de emendas constitucionais ou substituição de uma constituição por outra e tem como finalidade minar e atacar as instituições democráticas de direito. De início fez-se necessário abordar os conceitos e fundamentos teóricos referente ao fenômeno. Outrossim, foram elencados as características e modalidades do constitucionalismo abusivo para melhor identificá-lo, nesse sentido, foi possível identificar como características a manipulação do processo constituinte, a supressão de direitos fundamentais e a concentração excessiva de poderes, referente as modalidades baseiam-se no constitucionalismo episódico e no constitucionalismo abusivo estrutural. Por fim, foram analisados os impactos que podem ocorrer na democracia sendo um dos principais impactos a erosão na democracia bem como o retrocesso de todos os direitos conquistados através dela. Conclui-se que o fenômeno do constitucionalismo abusivo e o aumento de suas práticas é muito preocupante pois ocasiona em uma erosão na democracia e diminuição dos direitos fundamentais.
A constelação familiar como método alternativo de resolução de conflitos no direito de família
Authors: Oliskowski Gislaine Regina , Boldori Marcelo José
Published: December 2024

Em razão da enorme demanda do Poder Judiciário, que acaba resultando no acúmulo de inúmeros processos, bem como, da própria morosidade de suas soluções, tornou-se imprescindível se buscar outras alternativas que venham a auxiliar na resolução dessas problemáticas. Dessa forma, observa-se que o Novo Código de Processo Civil acabou abordando a conciliação e mediação, ressaltando tais meios como metodologias que proporcionam solução consensual de conflitos. Assim considerando, a pesquisa proposta pretende responder a seguinte questão problema: as constelações familiares, têm se mostrado eficazes como método alternativo de resolução de conflitos no direito de família? O objetivo geral do estudo foi estudar a Constelação Familiar como método alternativo na resolução de conflitos no Direito de Família. Metodologicamente, o estudo foi compreendido pela pesquisa bibliográfica, documental e método dedutivo. Os resultados encontrados buscaram elucidar a Constelação Familiar dentro do Direito Sistêmico buscou em determinados Tribunais de Justiça, contribuir com o Judiciário para redução da sobrecarga de processos na área do Direito de Família, bem como, promovendo aos jurisdicionados uma solução de conflito harmônica e pacífica. Conclui-se que diante da utilização da Constelação Familiar nas demandas judiciais, a mesma é respaldada pela Resolução nº 125/2010, do Conselho Nacional de Justiça. Logo, buscando proporcionar meios para soluções consensuais nos conflitos no Direito de Família, dentro dessa metodologia é possível evidenciar pontos positivos em relação as controvérsias diante do conflito, o que vem a resultar no favorecimento de uma solução pacífica pelos demandantes.
Environmental Education and Green Marketing as Mechanisms for Sustainable Awareness
Authors: Moraes Larissa Cristina Neto de , Oliveira Maira Danuse Santos de , Oliveira Keithy Juliane de , Bonomo Brunno , Campos Daniel Ferreira , João Belmiro do Nascimento , Araújo Nícolas Matheus da Fonseca Tinoco de Souza , Passos Christian Ricardo Silva , Nascimento Ana Verônica Silva do , Santos Adelcio Machado dos , Leite David Francisco Vieira , Lima Hyasnaia Luanna Barros de Oliveira Silva
Published: December 2024

Objective: The objective of the research was to investigate the performance of environmental education and green marketing as mechanisms of sustainable awareness, seeking to understand their interrelation and impact on the promotion of responsible practices on the part of consumers.
 
Methodology: The research used a qualitative approach, characterized as exploratory and descriptive. The sample was composed of 25 marketing managers from companies that apply green marketing strategies. The data were collected through in-depth interviews and analyzed using the technique of discourse analysis.
 
Results and Analysis: The results revealed that environmental education is key to empowering consumers to make informed and informed decisions. Green marketing, in turn, has proven to be an effective strategy for communicating sustainable actions, underlining the importance of transparency and authenticity in building consumer confidence. In addition, the analysis highlighted that the integration between environmental education and green marketing is crucial as it allows businesses and consumers to become allies in promoting a culture of sustainability. The research also indicated that the ongoing commitment of companies to sustainable practices is essential for the effectiveness of these initiatives.
Conclusion: In conclusion, the research showed that, for green marketing and environmental education to be effective, a continuous commitment of companies to adopt sustainable practices in a structured and strategic manner is necessary. The integration of these approaches promotes a sustainable awareness that benefits both organizations and society, reinforcing the importance of collaborative actions in search of a more balanced and responsible future in relation to the environment.
Anthropometry, Neuroergonomics and Immersive Technologies for the Workplace’s Future: Safer, Self-Sustainable and Digital
Authors: Moura Roque Antônio de , Villarta Cleiton José Benedito , Benevides Marcello Pereira , Richetto Marco Rogério Silva Richetto , Rosa Junior Orlando , Santos David Felipe Alves
Published: December 2024

Objective: The objective of this research is to identify the best ways to organize tasks, design interfaces and optimize work processes while respecting the cognitive limits, body size and know-how of the workforce.
 
Theoretical Framework: It is possible to prevent occupational and work-related diseases. The future of work is being shaped by a convergence of disciplines that seek to optimize the interaction between humans and machines.
 
Method: The method used included publications related to the topic on immersive training, movement programming and respect for anthropometric differences between genders.
 
Results and Discussion: The results indicate a reduction in mental fatigue, a reduction in the cognitive load in tasks with the creation of work routines and greater attention and productivity.
 
Research Implications: This review research shows how neuroergonomics, anthropometry and immersive technologies, considered pillars of transformation, have the potential to create safer, more efficient work environments adapted to the individual needs of workers.
 
Originality/Value: The study of the physical dimensions and physical-mental characteristics of the human body in the design of equipment and workspaces makes it possible to create more comfortable and safe environments, reducing the risk of repetitive strain injuries and occupational diseases.
“Privacy Is Overrated”: Situating the Privacy-related Beliefs and Practices of Italian Parents with Young Children
Authors: Zaffaroni Lorenzo Giuseppe
Published: December 2024

The widespread surveillance of everyday family life poses threats to parents’ and children’s right to privacy. Even though considerable research on privacy in families with young children exists, more evidence on the interplay between contextual factors and privacy issues is needed to enrich our understanding of privacy as grounded in everyday family life. To this aim, this paper conceptualises privacy as a situated and emergent phenomenon related to family cultures, socioeconomic background, technological imaginaries, and other significant markers of everyday family life. Drawing on qualitative data from a longitudinal research project with parents of children aged zero to eight, the study shows that privacy risks and threats are mostly associated with the interpersonal context; corporate and institutional surveillance are naturalised within notions of convenience or resignation to big-tech corporations. As technological and surveillance imaginaries influence such a complex web of privacy dynamics, this paper advocates for a situated and contextual approach to family privacy and surveillance in times of datafication.
Cardiopleurocutaneous fistula due to patch dehiscence of the left ventricular wall: a case report
Authors: Alsudais Moath , Alqahtani Nayef , Alluhaydan Omar , Alkhathlan Khalid
Published: December 2024

Background: Left ventricular pseudoaneurysm is a rare but serious complication of cardiac surgery, often associated with significant morbidity and mortality. Timely recognition and management of postoperative complications are crucial, as they can lead to severe outcomes.
Case Presentation: We describe a 65-year-old man with a history of type II diabetes mellitus, hypertension, and recent cardiac surgery for left ventricular pseudoaneurysm repair. He was presented with a red oozing discharge from the draining tube site, shortness of breath, and generalized body swelling. Despite initial stability, his condition rapidly deteriorated, leading to septic shock and complications, including patch dehiscence, cardiopleurocutaneous fistula, and active bleeding.
Conclusion: This case underscores the critical role of imaging in detecting and managing rare postoperative complications, such as cardiopleurocutaneous fistulas, following cardiac surgery. Early identification and intervention are essential to improving outcomes in such challenging cases.
Altered mental status in the emergency department and the findings of computed tomography
Authors: Alanazi Mazi , Kamal Yara , Binrabaa Ibrahim , Alhusayni Muhannad , Alkhannani Faisal , Alhassan Abdullah , Aljaddua Salem , Alshammari Faisal , Asiri Ali , Althobiti Manal
Published: December 2024

When a patient presents to the emergency room with an acute altered mental state, a computed tomography (CT) scan of the head is frequently performed. The outcomes of positive CT tests and their connection to changes in clinical treatment are assessed. The study was conducted by the Preferred Reporting Items for Systematic Reviews and Meta-analyses standard and the PubMed, CINAHL, Embase, and PubMed Central databases were searched. The chosen studies ranged from the year 2019 to 2023. Five studies totaling 13,172 patients were included in this analysis including two retrospective case-control studies, two cohort studies, and one observational, quasi-experimental research. The United States, Taiwan, Italy, Israel, and India were the locations of the studies. The outcomes of the included studies were hemorrhage, mass effect, hydrocephalus, worsening of previous findings, intra-cerebral hemorrhage, space-occupying lesions, new ischemic infarction, hydrocephalus, bleeding, ischemic stroke, herniation, and intracranial hemorrhage. In most non-traumatic individuals with changed mental states, no significant CT abnormalities were found. Serious conditions were observed in a small percentage of individuals.
Aerosole: das ignorierte Problem
Authors: Scheuch Gerhard
Published: December 2024

One central topic has been criminally neglected in the analysis of the corona pandemic: the role of aerosols in the transmission of viruses.
Aerosol medicine had already established before 1990 that even when breathing calmly, tiny aerosol particles are released from the bronchi or lungs. When infected with a respiratory virus, the quantity of exhaled aerosol particles increases by up to three powers of ten, but only in the so-called 'superemitters' (superspreaders). It is not known why only a small proportion of those infected become superemitters.
Praxisnetze in Deutschland: Struktur, Zusammenarbeit und Schwerpunkte
Authors:   Technische Universität München, Bammert Philip , Schüttig Wiebke ,   Technische Universität München, Kropp Saskia ,   Technische Universität München, Brittner Matthias ,   KVWL, Gerlach Roman ,   Kassenärztliche Vereinigung Bayerns, Sundmacher Leonie ,   Technische Universität München
Published: December 2024

The outpatient sector in Germany is characterised by special features, including organisational separation from the inpatient sector, the free choice of doctor for patients and the lack of standardised communication channels between service providers (1). This makes coordination and continuity of care more difficult, which can ultimately lead to cuts in the quality of care for patients. Examples of negative consequences of uncoordinated care include excessive utilisation of healthcare services, interruptions to treatment pathways or incorrect medication. In particular, multimorbid patients with a high demand for healthcare services are at risk of inappropriate care. There is potential for development with regard to collaborative professional practice in the outpatient sector and care models are needed that improve cooperation and coordination in care.
Föderalismus im Rettungsdienst – der arztbegleitete Sekundärtransport im Ländervergleich
Authors: Holbe Fabian
Published: December 2024

The consolidation of the hospital market is being driven by economic constraints, as smaller facilities are often no longer able to operate profitably. The trend towards centralisation is being driven politically by the hospital reform and is intended to improve the quality of care through specialisation and concentration of resources. However, by 2022, only 1075 hospitals in Germany will still have the capacity to provide intensive care [1].
PROMs und PREMs für systematische Qualitätssteigerung
Authors:   APS, Hecker Ruth
Published: December 2024

>> Following the end of the traffic light government, the current legislative procedures in the area of healthcare are unlikely to end quite as easily as Health Minister Prof Dr Karl Lauterbach had imagined. This applies to the Healthcare Strengthening Act, the reform of emergency care, the Health Digital Agency Act, the Nursing Competence Act, a bureaucracy relief act announced for this autumn and the Healthy Heart Act.
Pemanfaatan Limbah Cangkang Kelapa Dan Kulit Kakao Sebagai Komposit Batu Bata Ringan Untuk Media Peredam Kebisingan
Authors: Shabrina Jihan , Marsyad Hardoyo , Ergantara Rani Ismiarti
Published: December 2024

Kebisingan merupakan bunyi yang tidak diinginkan dari usaha atau kegiatan dalam tingkat dan waktu tertentu yang dapat menimbulkan gangguan kesehatan manusia dan kenyamanan lingkungan. Industri perumahan kini semakin banyak memodifikasikan bentuk dan kualitasnya termasuk dinding yang perlu dimodifikasi dengan cara menambahkan media komposit untuk meningkatkan daya redam kebisingan dari luar rumah. Tujuan penelitian ini untuk mengetahui apakah serbuk cangkang kelapa (Cocos nucifera L) dan serbuk kulit kakao (Theobroma cacao) dapat digunakan sebagai bahan campuran batu bata ringan sebagai media peredam kebisingan. Penelitian ini dilakukan dengan menyusun 27 batu bata berukuran 16,5cm x 6,5cm x 5cm dalam 1 pengukuran ke dalam kotak pada bagian terbuka berukuran 54cm x 51cm x 50cm berbahan kayu sengon. Sumber suara berupa audio lonceng dengan volume paling tinggi. Komposit serbuk cangkang kelapa dan serbuk kulit kakao dengan variasi 0 persen, 15 persen dan 25 persen. Pengambilan data dilakukan setiap 5 detik selama 10 menit sehingga diperoleh 120 data dalam 1 pengukuran. Pengukuran dilakukan dua kali percobaan. Hasil pengukuran tingkat kebisingan menunjukkan rata-rata tingkat kebisingan pada kondisi kontrol tanpa menggunakan batu bata adalah 89,4 dB, batu bata variasi 0 persen adalah 83,0 dB, komposit serbuk cangkang kelapa 15 persen adalah 80,8 dB, komposit serbuk cangkang kelapa 25 persen adalah 77,4 dB, komposit serbuk kulit kakao 15 persen adalah 73,5 dB, dan komposit serbuk kulit kakao 25 persen adalah 71,3 dB. Hasil penelitian menunjukkan bahwa batu bata variasi 25 persen dapat menurunkan tingkat kebisingan, dengan nilai efisiensi tingkat penurunan serbuk cangkang kelapa variasi 25 persen sebesar 13,4 persen dan efisiensi penurunan tingkat kebisingan batu bata dengan komposit serbuk kulit kakao variasi 25 persen sebesar 20,2 persen.
Indigenous Practices of Women during Pregnancy, Labour and Puerperium among Cultural Groupings at Selected Hospitals in Limpopo Province, South Africa
Authors: Mabusela Anikie , Ngoatle Charity , Mothiba Tebogo , Bopape Mamare
Published: December 2024

Indigenous practices are performances that occur naturally in a region. Most women believe in Indigenous practices because of their cultures and social structure. In South Africa, regardless of the availability and accessibility of maternal and child health services, 50% of women still consult traditional birth attendants as their first choice during pregnancy, labour, delivery and postnatal care. A qualitative research approach was applied with an explorative and descriptive design to explore the Indigenous practices of women during pregnancy, labour and puerperium among cultural groupings. Non-probability purposive sampling was used to select 25 participants and data was collected through semi-structured interviews with a guide until data saturation was reached. Data was analysed using tech’s open coding method. The study showed most women use Indigenous practices for protection against witchcraft and a fear of caesarean section. This study will help pregnant women to be aware of the harmful Indigenous practices that can affect their own health and that of their baby. It will also help nurses provide holistic nursing care, taking into consideration pregnant women’s cultures and beliefs. The study recommends that nursing education include Indigenous practices in the curriculum so that healthcare practitioners know about them. This could reduce maternal and child morbidity and mortality.
Impact of catheter location during mesenteric angiography in identifying sources of acute lower gastrointestinal bleeding
Authors: Lain William Joseph , Zhao Patricia , Sheeran Daniel P. , Patrie James T. , Wilkins Luke R.
Published: December 2024

Objectives:

The objective of this study was to compare the sensitivity of selective to superselective mesenteric angiography in identifying acute lower gastrointestinal bleeding (LGIB) after computed tomography angiography (CTA) demonstrating active arterial bleeding.

Material and Methods:

This is a single-center retrospective study of all patients who underwent mesenteric angiography to evaluate LGIB between January 2012 and September 2021. The inclusion criterion was a CTA demonstrating active arterial LGIB immediately before intervention. Patient demographics, etiology of bleeding, and procedural details were recorded. Selective angiography was defined as an ostial visceral branch injection; superselective was defined as any selection into or beyond a 2nd order branch. Technical success was defined as the successful embolization of the target vessel. Clinical success was defined as the clinical resolution of gastrointestinal bleeding without additional procedural or surgical interventions within 30 days.

Results:

After inclusion criteria, 78 angiograms from 72 patients were evaluated. Active arterial bleeding was identified in 50% (39/78) of angiograms, and embolization was performed in 49% (38/78) of cases. The diagnostic sensitivity of superselective angiography was significantly greater than selective angiography (56.3% vs. 32.1%, P = 0.018). In 12.8% (10/78) of all angiograms, active bleeding was identified only with superselective angiography (25.6%, 10/39, of cases where any bleeding was identified). Embolization was performed in 38 of the angiograms; technical success was 97.4% (37/38), clinical success was 71.1% (27/38), and 26% (10/38) required further intervention. Embolization was not performed in 40 angiograms, with 68% (27/40) requiring an additional intervention.

Conclusion:

Superselective angiography is significantly more sensitive than selective angiography for patients with known acute LGIB identified on CTA.
Seizure-related bilateral asynchronous displaced late presenting Delbet type I fractures: A case report and literature review
Authors: El-Adwar Khaled L.
Published: December 2024

Delbet type I transphyseal hip fractures without dislocation are extremely rare injuries. This is the first report of a bilateral case caused by seizures. A 4-year-old girl with global developmental delay, who walks supported, fell off her bed during an epileptic fit. The parents presented two weeks later, and radiographs revealed a displaced right Delbet type I transphyseal upper femoral separation. Under general anesthesia, surprisingly, the physis was reduced anatomically using the Leadbetter maneuver. Fixation was carried out with three smooth Kirschner wires (KWs), after which uneventful healing occurred. Sixteen months following the first injury, the girl had another seizure, which resulted in a buckle fracture of her left distal femur. Unfortunately, an identical left hip physeal injury was missed. On presentation three months later, stress radiographs showed non-union of the physis. Fortunately, again, the Leadbetter maneuver succeeded in reducing the physis, which was fixed using two smooth KWs. She was seen one year following the left hip surgery (2.5 years after the right hip surgery), and the left physis had united with no ischemic necrosis on both sides. The patient then resumed her ability to walk supported and sit cross-legged. A telephone call to the father six years post-surgery to the right hip and four years and six months post-surgery to the left hip confirmed that she was asymptomatic and maintained her previous abilities. Because of the COVID-19 pandemic, she could not attend for clinical and radiographic examinations.
Biodegradation of Model Solid Waste from Palm Oil production by Micromycete Strains
Authors: Gerasimchuk Anna L. , Topilina Yulia S. , Glukhova Lubov B. , Prasetyo Endry Nugroho , Frank Yulia A.
Published: December 2024

The study employed micromycetes of the genus Penicillium isolated from solid waste generated in palm oil production. For P. goetzii strain ZCMC-01M and P. chrysogenum strain ZCMC-02M, the lipolytic activity on tributyrin agar and the potential of palm oil as a growth substrate were revealed. Both strains showed specific activity of laccases, peroxidases and Mn-peroxidases. The biodegradation of solid waste by Penicillium strains was studied in the experiments conducted using a mixture of coconut fiber and palm oil in a 1:1 ratio. After 30-day incubation at 22℃ and 32℃, the mass fraction of dry matter in waste was found to decrease in both strains by not less than 11% and 7% respectively, compared to the control.

The mass fraction of lipids decreased by not less than 9% and 6%, respectively. The maximum acid value at both temperatures was recorded for P. goetzii strain ZCMC-01M; it increased more than 4-fold compared to the control. For P. chrysogenum strain ZCMC-02M, the acid value increased 3.9 and 3.7 fold at 22℃ and 32℃ respectively. The results obtained indicate that representatives of P. chrysogenum and P. goetzii isolated from waste with a high content of palm oil can effectively biodegrade this type of waste.
Theaflavins loaded niosomes: characterization and in vivo biodistribution in Wistar albino rats
Authors: Salim Payas , Mandal Abul Kalam Azad
Published: December 2024

Theaflavins (TFs), bioactive compounds present in black tea manufactured from leaves of Camellia sinensis, have potent health benefits. TFs are unstable and have low bioavailability due to their low solubility in water. In the present study, we have attempted to encapsulate TFs into niosomes to enhance stability, bioavailability, and therapeutic applications. This study explored the potential of niosomes loaded with theaflavins (TFs-L-NS), a formulation designed to overcome the limitations of the natural compound theaflavins (TFs).

TFs-L-NS was successfully developed with desirable characteristics including nanosize (111.5 nm), surface charge (-95.5 mV), encapsulation of TFs (78%), and in vitro release profile of TFs from TFs-L-NS (47%) with slow and sustained release. SEM, TEM, and fluorescent microscopic studies revealed that TFs-L-NS has a spherical form and a smooth surface. A two-month stability study indicated good stability of TFs-L-NS. In vivo studies demonstrated the distribution of DiR-labeled TFs-L-NS throughout the body and vital organs in a rat model.
Identification of the novel drug target for the treatment of HIV by using the Bioinformatics approach
Authors: Budhiraja Namrata , Peta Sreenivasulu , Singh Devendra
Published: December 2024

The virus known as human immunodeficiency virus, or HIV, targets the immune system of the body. HIV can result in a condition called acquired immunodeficiency syndrome, or AIDS, if it is not treated. The molecular docking method has been enthusiastically embraced by scientists and researchers. When predicting a small molecule's activity and affinity, docking is often utilized to predict how the molecule will align with its protein target. Molecular docking was carried out using Autodock 4.2 software. The ligands' ability to bind to proteins associated with sicknesses in the protein data library was examined. 3LII, 1HD2, 1QS4, 5CDQ, 3MNG and 2IOK were the proteins. Rosmarinic acid, thymol, caffeic acid, carvacrol, p-Cymene and coumaric acid were the ligands used. The best conformation with the lowest docked energy was chosen from the docking search results.

Human acetylcholinesterase (PDB ID: 3LII) and the HIV-1 integrase (PDB ID: 1QS4) both exhibit favorable binding energies to rosmarinic acid, Human PrxV (PDB ID: 3MNG), human peroxiredoxin 5 (PDB ID: 1HD2), human PrxV (PDB ID: 3MNG), human oestrogen receptor (PDB ID: 2IOK), human oestrogen receptor (PDB ID: 2IOK) and moxifloxacin structure with S. aureus (PDB ID: 5CDQ) all exhibit good binding energy with rosmarinic acid. The results of the ADMET analysis were found to be non-toxicity. This computational investigation has produced encouraging findings that may be investigated and ADMET drug-likeness properties have been confirmed, which can be further analysed in vivo and in vitro for its potential drug development.
Leucine repeat polymorphism in CNDP1 gene (D18S880) and Type 2 Diabetic kidney disease in South Indians
Authors: Ramesh V. , Lakshmiprabha S. , Ponnudhali D. , Jeyachandran G. , Sridevi M.
Published: December 2024

The global concern is the alarming increase in the high proportion of Diabetes Mellitus affecting nearly all populations which in turn emphasized the urge to investigate the role of susceptibility genes contributing to the disease burden. The highly vulnerable genes accountable for promoting type 2 Diabetic Kidney Disease (T2DKD) in South Indians are not well studied. This study is an attempt to research the possible association between (CTG)n trinucleotide repeats in Carnosinase or Carnosine dipeptidase 1 (CNDP1) gene and Diabetic Kidney disease (DKD) in South Indian population. The repetitive sequence of CTG in CNDP1 gene was amplified from the genomic DNA of total 285 [T2DKD, n:85; Type 2 Diabetes Mellitus (T2DM), n:100; healthy controls (HC), n:100] subjects using DNA sequencing method and was examined by a case-control approach.

The significant trinucleotide repeats in our study were homozygous 5/5 leucine, heterozygous 5/6 leucine and homozygous 6/6 leucine. T2DKD had a lower frequency of homozygous 5/5 leucine genotype (23.5%) than T2DM (37%, P=0.047) and HC (41%, P=0.011). Likewise, five leucine allele (5L) recurrence was lower in T2DKD (45.9%) when compared with T2DM (59.5%, P=0.008) and HC (62.5%, P=0.001). T2DKD showed lower frequencies of homozygous 5/5 leucine genotype and five leucine allele (5L) of CNDP1 gene when compared to T2DM and HC. These findings established that this allele may offer defence against the onset of kidney disease in South Indians.
Enhancing Sodium Removal from Greywater using Modified Tripoli Adsorbents
Authors: Al-Sarayreh Sajeda , Aljbour Salah H. , Al-Harahsheh Adnan , Al-Hamaiedeh Husam
Published: December 2024

Greywater, a byproduct of domestic activities, contains various contaminants including sodium ions which can adversely affect soil and plant health and industrial processes. This study explores the use of Tripoli, a sedimentary rock abundant in Jordan and its modified forms as potential adsorbents for sodium removal from greywater. X-ray fluorescence analysis revealed significant changes in chemical composition of Tripoli upon treatment with sulfuric acid and hydrochloric acid.

Kinetic studies using the Weber and Morris intra-particle diffusion model demonstrated a high degree of agreement between experimental data and model predictions, with the rate constant (K) indicating enhanced intra-particle diffusion in samples treated at 1000°C. These findings highlight the potential of Tripoli and its modified forms as cost-effective and environmentally friendly adsorbents for sodium removal from greywater.
Analytical Method Development and Validation for the Quantification of Ciprofloxacin by HPLC
Authors: Reddy Ramireddy V. , Dighore N. , Rajbhoj A. , Gaikwad S.
Published: December 2024

A simple method using the HPLC system to quantify ciprofloxacin was developed and validated. The chromatographic separation of ciprofloxacin was carried out using Waters XTerra MS C18 column (100 × 3.0 mm: Particle size: 5 μm), UV detection at 278 nm and a gradient program which consists of a mobile phase of 0.1% v/v formic acid in water and acetonitrile at a flow rate of 0.8 mL/min. The developed method was validated using ICH guidelines for precision, specificity by degradation, linearity, accuracy, range and robustness. The retention time of ciprofloxacin was about 6.45 minutes.
Synthesis and Anticancer Activity of New 2-methylquinoline with Pyridine, Thiazole and Pyrazole Derivatives
Authors: Kudikala Sadanandam , Prasad Pinnoju , Manasa S.K. , Madderla Sarasija
Published: December 2024

This work presents a novel class of 2-methylquinoline derivatives that combine pyridine, thiazole, pyrazole ring systems. The precursor 1-(2-methylquinolin-3-yl) ethanone (1) is combined with aldehydes, malononitrile and ethyl cyanoacetate in a one-pot synthesis to produce 2-amino-6-(2-methylquinolin-3-yl)-4-phenylpyridine hybrids 2 and 3. Synthetic approaches to the (E)-1-(1-(2-methylquinolin-3-yl) ethylidene) hybrids 5, 6, to treat 1 with thiosemicarbazide and 1-chloropropan-2-one and to get 7, 8, the compound 1 is treated with bromine and thiourea. Then by using 2-chloroacetyl chloride and ammonium thiocyanate compounds 9, 10 were prepared.

Furthermore compound 11 is formed when dimethoxy-N,N-dimethylmethanamine and xylene are treated with compound 1. The 2-methyl-3-(1H-pyrazol-3-yl) quinoline motif 12 was prepared by reacting 1 with dimethylamine and then treating the mixture with hydrazine. When examined in vitro on A549 and MCF-7 cancer cell lines, the anti-cancer effects were comparable to those of doxorubicin.
Application of V2O5 screen printed sensor for acetone
Authors: Mahaliya Ankita J. , Kapse H.N.
Published: December 2024

Vanadium pentoxide has gathered significant attention among transition metal oxide semiconductors over the years due to its applications in various fields. It is a non-stoichiometric and promising material for gas sensing, optoelectronic, microelectronic and electrochemical devices. Vanadium pentoxide has excellent properties including good thermoelectric characteristics, strong chemical and thermal durability, wide optical band gap and multiple valences. These properties make it an excellent choice for the fabrication of innovative electronic devices and functional materials that can work in their intended conditions. Acetone is a hazardous and easily ignited gas that finds extensive applications as a solvent, chemical intermediary, medication and cosmetic. There are several volatile organic compounds (VOCs) inhaled by the people. Acetone is the most volatile of the VOCs and is frequently utilized in industries and laboratories as an organic solvent or chemical intermediary. The normal range of acetone for human breathing is 300ppb – 900ppb. The excess inhalation causes biliousness, indolence and drowsiness of the nervous system as well as irritation of the eyes and respiratory system.

The majority of acetone detection methods rely on table top instruments like Mass Spectrometry with Gas Chromatography or Proton Transfer Reaction which are bulky and costly too. In view of this, the present work is focused to detect acetone via chemo-resistive sensing method. We have fabricated screen printed Vanadium pentoxide electrode to sense acetone. The sensitivity was found to be increased with gas concentration. This shows that vanadium pentoxide could be good sensor for acetone detection. The advantage of this sensor is its ease of operation and economy for large scale utilization.
Antioxidant activity and induction of cell cycle arrest by Curcuma amada roxb extracts in acute T lymphoblastic leukemia cell lines
Authors: Mathew Blessy Baby , Krishnamurthy T.P. , Mohapatra Biswajit , Gowthami S. , Joshi Vaishnavi
Published: December 2024

This study was undertaken to evaluate the phytochemical, antioxidant and anti-cancer efficacy of Curcuma amada rhizome extracts against acute T lymphoblastic leukemia cell lines. The antioxidant activity of the extracts was studied by DPPH assay, TAC and by estimating the phyto-constituents present. The reducing property of the extracts was determined by assessing the ability of the extracts to reduce FeCl3 solution. The cell viability, proliferation and resistance towards cell toxicity were evaluated by MTT assay and the effect of Curcuma amada test extracts on the cell cycle of acute T lymphoblastic leukemia cell lines (JURKAT) was analyzed by flow cytometry. The Curcuma amada extract treatment of 100 and 200 μg/ml was found to be arrested to 13.37% and 25.96 % at G2M phase of cell cycle respectively when compared to untreated Jurkat cells (8.32 %). Asparaginase showed 49.92 % of cell cycle arrest at G2M phase.

When the concentration of Curcuma amada roxb extracts increased from 100 μg/ml to 200 μg/ml, a greater number of cells were seen in G2/M phase and lesser number were there in the S phase indicating that there was a decline in the formation of new daughter cells i.e. it was not allowing the cells to multiply faster. The number of doublets seen was very few when compared to the cells seen while using the standard drug Asparaginase. The cytopathology observed after Curcuma amada extract treatment was rounding and clumping of cells, detachment of cells, cell flagging and apoptosis. The results demonstrate the strong antioxidant and protecting potential of Curcuma amada rhizome extract towards DNA damage and mark it as a potential source of natural antioxidant and anti-cancerous activity at various acute phases of T lymphoblastic leukemia.
Evaluation of morpho-cellular and spectroscopic characteristics of Myristica fragrans Houtt mace across three different maturation stages (juvenile, raw and ripe)
Authors: Chacko Anish Mathew , Nag Anish
Published: December 2024

This study was based on comprehensive analysis of Myristica fragrans Houtt mace samples across various stages of maturation (juvenile, raw and ripe). The anatomical analysis was performed using SEM coupled EDX spectroscopy that revealed distinct cellular changes and the presence of oil-storage structures in the mace. The EDX analysis further confirmed the presence of key elements such as carbon (C), oxygen (O) and potassium (K) which contribute to mace's pharmacological properties. Spectrophotometric analysis revealed a steady increase in chlorophyll content as the mace matures, with total chlorophyll content rising from 1.02 during the juvenile stage to 1.25 at the raw stage and reaching 3.29 at the ripe stage.

The Plant Senescence Reflectance Index (PSRI) shows a rise in carotenoid content, increasing from 0.15 in the juvenile stage to 0.17 at the raw stage and reaching 0.82 at the ripe stage. This increase correlates with the mace's colour transformation to crimson red during ripening. The FTIR spectroscopy analysis provided a detailed chemical characterization of the mace, identified various functional groups (carboxylic acid, aldehyde, alkanes, azides) and organic molecules. The presence of multiple functional groups across the maturation stages suggested a complex composition that likely contributes to the mace's sensory and pharmacological qualities.
Challenges in the management of renal dialysis in diabetic patients: a prospective study
Authors: Rani Narayana Muthu , Tejasree P , Jaswanthi Ch , Vamsi V.Leela Krishna , Prasath M.Ajay
Published: December 2024

This study examines the challenges associated with managing diabetic patients undergoing renal dialysis in the nephrology department. The primary objective is to address the difficulties encountered during dialysis by improving its management, preventing the progression of chronic kidney disease to end-stage renal failure, and systematically reviewing the indications for and complications of dialysis. Managing dialysis in diabetic patients is particularly complex due to the added burden of diabetes-related issues. These patients often experience higher rates of infections, increased cardiovascular morbidity, and elevated mortality risks. Other challenges include fluid overload, complications arising from the dialysis procedure itself, psychological distress, and a diminished quality of life. These interconnected issues necessitate a comprehensive and multidisciplinary approach to improve patient outcomes. To enhance the quality of life for patients with diabetic nephropathy, it is crucial to involve a team of specialists. The multidisciplinary team should include a diabetologist, nephrologist, dietitian, microbiologist, vascular surgeon, and interventional radiologist. Each specialist contributes unique expertise to address the various complications and facets of care, ranging from infection control to vascular access and dietary management. Ultimately, overcoming the challenges of managing diabetic patients on dialysis requires collaboration, innovation, and a commitment to improving their overall health and well-being through tailored care strategies.
HORTICULTURE THE GLOBAL COUNTRY
Authors: J Ayushi Trivedi
Published: December 2024

Horticulture has always held a unique place within the world of agriculture, blending art, science, and practical skill to cultivate the fruits, vegetables, flowers, and landscapes that nourish both body and spirit. It is a field that not only sustains life but enriches it, creating beauty and fostering biodiversity. My journey as a horticulturist has been one of constant discovery, and it is with great excitement that I present - Horticulture: The Fascinating World.
9Örgütsel Dayanıklılığın(OrganizationalResilience) Faaliyet Raporlarına Yansıması Bağlamında İçerik Analizi (Content Analysis in the Context of the Reflection of Organizational Resilience on Activity Reports)
Authors: Kıyık Kıcır Güzin
Published: December 2024

İş dünyasının dinamik ve belirsiz çevresel şartları içinde ayakta kalmaya çalışan işletmeler açısından önemli konulardan birisi de örgütsel dayanıklılıktır. Bu çalışma, Türkiye’nin önde gelen işletmeleri arasından seçilen örneklem üzerinden örgütsel dayanıklılığı analiz etmeyi amaçlamaktadır. Araştırma döneminde BİST 100 işletmeleri listesinde yer alan, işlem hacmi yüksek beş işletme çalışmanın kapsamını oluşturmaktadır. Veriler ikincil düzey kaynak niteliğindeki faaliyet raporlarından toplanmıştır. Analiz aşamasında ise işletmelere dair bilgiler, kelime frekansları, belirlenen kategori ve kodlar aracılığıyla içerik analizi gerçekleştirilmiştir. Türkiye’de güçlü görülen işletmelerin örgütsel dayanıklılığı nasıl algıladığı ve bu anlamda neler yaptıklarının çözümlenmesi hem kavramın doğru anlaşılabilmesi hem de yeni nesil genç işletmelere öneriler içermesi bağlamında önemlidir. Araştırma sonucunda; çalışmaya dahil olan işletmelerin örgütsel dayanıklılıkları işletme yaşı, atlatılan krizler ve ayakta kalma yeterlilikleri nedeniyle yüksek görülmüştür. Ayrıca faaliyet raporlarında örgütsel dayanıklılık için önemli kriterler olan esneklik, çeviklik, kalite, farkındalık gibi kavramların sık kullanılmadığı, risk takibi ve uyum gibi kavramların ise öne çıktığı görülmektedir.
Somut Olmayan Kültürel Miras Kapsamında Yaratıcı Şehirler Ağı: Bursa Örneği (Kavramsal Bir Analiz) (The Network of Creative Cities Within the Scope of Intangible Cultural Heritage: The Case of Bursa (A Conceptual Analysis))
Authors: Zengin Burhanettin , Şen Lütfi  Mustafa
Published: December 2024

Birleşmiş Milletler Eğitim, Bilim ve Kültür Örgütü(UNESCO) yaratıcı şehir ünvanıalan şehirler, kültürel mirası korumakta ve yenilikçi çözümlerin geliştirilmesine zemin hazırlamaktadırlar. 2021 yılında Yaratıcı Şehirler Ağı’na üyeliği kabul edilen Bursa, zanaat ve halk sanatı alanında dikkat çekmektedir. Bursa’nın UNESCO Yaratıcı Şehirler Ağı’na (UCCN) katılım sürecinin incelenmesi ve bu süreçte Somut Olmayan Kültürel Mirasın(SOKÜM)tanıtımı ve geliştirilmesinde turizmin aracı rolüne odaklanan çalışmada el sanatlarının, sadece estetik bir unsur olmadığı aynı zamanda toplumların kültürel kimliği ve benliğinin devamlılığı için taşıdığı anlam ve öneme dikkat çekilmiştir. Yaratıcı şehir kimliğinin soyut ve çok yönlü yapısı nedeniyle teorik çerçevede incelemenin yapılması önem arz etmektedir. Bu bağlamda UCCN’ yekatılımın bir örneği olarak Bursa’nın yaratıcı şehir kimliği, kentin yerel, ulusal ve uluslararası düzeydeki katkıları ve kazanımlarının anlaşılması ve kavramsal çerçeveyle analiz edilmesi amaçlanmıştır. El sanatları aracılığıyla yerel halkın katılımını teşvik eden yenilikçi ve yaratıcı pazarlama stratejilerinin, turizm entegrasyonu ile bir araya geldiğinde bölgenin kültürel zenginliklerinin etkili bir şekilde tanıtılmasına katkı sağlayacağı sonucuna ulaşılmıştır.
Dijital Sergilemede Maliyet Unsurları (Cost Elements in Digital Exhibition Production)
Authors: Çına Bal Emine , Bülbül Sevil
Published: December 2024

Dijitalleşmenin hız kazanmasıyla birlikte görsel sanat eserleri, fiziksel mekanlarla sınırlı kalmayıp çevrim içi platformlarda da sergilenmeye başlamıştır. Bu çalışma dijital bir sergi oluşturmanın maliyet unsurlarını belirlemek için "Sezen Aksu Dijital Sanat Sergisi" örneği üzerinden bir inceleme sunmaktadır. Çalışmada, öncelikle dijital sergilere öncülük eden deneysel sanat eserleri ve teknolojinin dijital sergilemeye etkisi tarihsel bir perspektifle ele alınmıştır. Bu maliyet unsurları arasında profesyonel ücretler, teknoloji ve donanım maliyetleri, yapım ve tasarım maliyetleri, pazarlama ve tanıtım maliyetleri, müze kirası ve izinler, personel maliyetleri, hediyelik ürün ve mağaza maliyetleri ile ek maliyetler yer almaktadır. Çalışmanın sonuçları, dijital sergi üretiminin çeşitli maliyet unsurlarını içerdiğini ve özellikle teknoloji ve donanım maliyetlerinin toplam maliyetin önemli bir kısmını oluşturduğunu göstermektedir. Bu çalışma, gelecekteki dijital sergi projeleri için planlama ve bütçeleme aşamalarında faydalı bir kaynak olabilir.
Care-educational game for men who have sex with men and live with HIV and Aids
Authors: Mariano Maria Tereza Leite , Leite Márley Romão , Mandelli Bárbara Furtado , Nascimento Maria Mônica Paulino do , Fernandes Marcelo Costa , Temoteo Rayrla Cristina de Abreu , Silva Cícera Renata Diniz Vieira
Published: December 2024

Objective: To describe the construction of a board game-type care-educational technology for the health education of men who have sex with men and live with the Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome, within the scope of Primary Health Care. Methods: Methodological study, developed from a participatory perspective in four stages: development of a scoping review; theorization and construction of the technology; appraisal; and final design. Results: The game “HIVIVENDO E APRENDENDO” was constructed considering the integrative perspective of care for the target population, addressing in its content aspects about the infection and the disease, welcoming, treatment adherence, related stigmas and prejudices, citizenship, and quality of life. Conclusion: With the developed care-educational technology, it is intended that, after the validation phase, it can become a facilitating tool for promoting health education for both professionals and users in Primary Health Care.