School-Based Cardiovascular Health Promotion in Adolescents
Authors: Santos-Beneit Gloria , Fernández-Alvira Juan M. , Tresserra-Rimbau Anna , Bodega Patricia , de Cos-Gandoy Amaya , de Miguel Mercedes , Ramírez-Garza Sonia L. , Laveriano-Santos Emily P. , Arancibia-Riveros Camila , Carral Vanesa , Orrit Xavier , Rodríguez Carla , Carvajal Isabel , Haro Domenec , Peyra Carles , Martínez-Gómez Jesús , Álvarez-Benavides Antonio , Estruch Ramón , Lamuela-Raventós Rosa M. , Fernández-Jiménez Rodrigo , Fuster Valentín 
Published: August 2023

Importance

School-based interventions offer an opportunity for health promotion in adolescence.

Objective

To assess the effect of 2 multicomponent educational health promotion strategies of differing duration and intensity on adolescents’ cardiovascular health (CVH).

Design, Setting, and Participants

The SI! Program for Secondary Schools is a 4-year cluster randomized clinical intervention trial conducted in 24 secondary schools from Barcelona and Madrid, Spain, from September 7, 2017, to July 31, 2021. Eligible participants were adolescents enrolled in the first grade of secondary school.

Interventions

Schools and their participants were randomized to receive a health promotion intervention (SI! Program) over 4 school years (long-term intervention [LTI], 8 schools, 412 adolescents) or 2 school years (short-term intervention [STI], 8 schools, 504 adolescents) or to receive the standard curriculum (control, 8 schools, 441 adolescents).

Main outcome and Measures

The primary end point was the between-group difference at 2 and 4 years in the change from baseline of the overall CVH score, as defined by the American Heart Association (range, 0-14 points, with a higher score indicating a healthier CVH profile). Intervention effects were tested with multilevel mixed-effects models. A complete-case intention-to-treat analysis was performed as the primary analysis.

Results

Of the randomized students, the study enrolled 1326 adolescents (684 [51.6%] boys, mean [SD] age, 12.5 [0.4] years at recruitment) with a study completion rate of 86.0%. Baseline overall CVH scores were 10.3 points in the LTI group, 10.6 points in the STI group, and 10.5 points in the control group. After 2 years, at halfway through the LTI and at the end of the STI, the difference in the CVH score change was 0.44 points (95% CI, 0.01-0.87; P = .04) between the LTI group and the control group and 0.18 points (95% CI, −0.25 to 0.61; P = .39) between the STI group and the control group. At 4 years, differences for the LTI and STI groups vs control were 0.12 points (LTI: 95% CI, −0.19 to 0.43; P = .42) and 0.13 points (STI: 95% CI, −0.17 to 0.44; P = .38). No adverse events were reported.

Conclusions and Relevance

Overall, the tested school-based health promotion strategies in this randomized clinical trial had a neutral effect on the CVH of the adolescents. Although there was evidence of a marginal beneficial effect at a point halfway through implementation in the LTI group, such a benefit was not noted at 4 years. Further research is warranted into the efficacy of school-based health promotion programs.

Trial Registration

ClinicalTrials.gov Identifier: NCT03504059