bluuebunny/crossref_metadata_2025 huggingface dataset:
Bioinformatics analysis of the pathogenic link between Epstein-Barr virus infection, systemic lupus erythematosus and diffuse large B cell lymphoma
Authors: Zhu Qian-Ying
Published: April 2023

Epstein-Barr virus (EBV) is a risk factor for diffuse large B-cell lymphoma (DLBCL) and systemic lupus erythematosus (SLE). While prior research has suggested a potential correlation between SLE and DLBCL, the molecular mechanisms remain unclear. The present study aimed to explore the contribution of EBV infection to the pathogenesis of DLBCL in the individuals with SLE using bioinformatics approaches. The Gene Expression Omnibus database was used to compile the gene expression profiles of EBV-infected B cells (GSE49628), SLE (GSE61635), and DLBCL (GSE32018). Altogether, 72 shared common differentially expressed genes (DEGs) were extracted and enrichment analysis of the shared genes showed that p53 signaling pathway was a common feature of the pathophysiology. Six hub genes were selected using protein–protein interaction (PPI) network analysis, including CDK1, KIF23, NEK2, TOP2A, NEIL3 and DEPDC1, which showed preferable diagnostic values for SLE and DLBCL and involved in immune cell infiltration and immune responses regulation. Finally, TF-gene and miRNA-gene regulatory networks and 10 potential drugs molecule were predicted. Our study revealed the potential molecular mechanisms by which EBV infection contribute to the susceptibility of DLBCL in SLE patients for the first time and identified future biomarkers and therapeutic targets for SLE and DLBCL.
Nationwide sample data analysis of additional surgery rate after anterior or posterior cervical spinal surgery
Authors: Yuh Woon Tak , Kim Minjung , Choi Yunhee , Han Junghoon , Kim Junhoe , Kim Taeshin , Chung Chun Kee , Lee Chang-Hyun , Park Sung Bae , Kim Kyoung-Tae , Rhee John M. , Park Moon Soo , Kim Chi Heon
Published: April 2023

Surgical outcomes of degenerative cervical spinal disease are dependent on the selection of surgical techniques. Although a standardized decision cannot be made in an actual clinical setting, continued education is provided to standardize the medical practice among surgeons. Therefore, it is necessary to supervise and regularly update overall surgical outcomes. This study aimed to compare the rate of additional surgery between anterior and posterior surgeries for degenerative cervical spinal disease using the National Health Insurance Service-National Sample Cohort (NHIS-NSC) nationwide patient database. The NHIS-NSC is a population-based cohort with about a million participants. This retrospective cohort study included 741 adult patients (> 18 years) who underwent their first cervical spinal surgery for degenerative cervical spinal disease. The median follow-up period was 7.3 years. An event was defined as the registration of any type of cervical spinal surgery during the follow-up period. Event-free survival analysis was used for outcome analysis, and the following factors were used as covariates for adjustment: location of disease, sex, age, type of insurance, disability, type of hospital, Charles comorbidity Index, and osteoporosis. Anterior cervical surgery was selected for 75.0% of the patients, and posterior cervical surgery for the remaining 25.0%. Cervical radiculopathy due to foraminal stenosis, hard disc, or soft disc was the primary diagnosis in 78.0% of the patients, and central spinal stenosis was the primary diagnosis in 22.0% of them. Additional surgery was performed for 5.0% of the patients after anterior cervical surgery and 6.5% of the patients after posterior cervical surgery (adjusted subhazard ratio, 0.83; 95% confidence interval, 0.40–1.74). The rates of additional surgery were not different between anterior and posterior cervical surgeries. The results would be helpful in evaluating current practice as a whole and adjusting the health insurance policy.
Systemic effects of oral tolerance in bone healing
Authors: Costa Bruno Henrique , Rezende Alisson Kennedy , Costa Lais , Neves Gabrielle Fernanda Monteiro , Shimano Antônio Carlos , de Oliveira Penoni Álvaro , Carvalho Claudia Rocha , Costa Raquel Alves , de Alvarenga Erika Costa
Published: April 2023

Bone fractures cause acute inflammation that, despite being important for initial repair, may delay the healing of the damaged bone. Parenteral injection of dietary protein has been shown to decrease inflammation and accelerate the repair of skin wounds and other inflammatory pathologies. Thus, our aim was to evaluate whether the intraperitoneal (i.p.) immunization with zein, an abundant protein in rodent chow, would favor bone healing. Wistar rats received i.p. immunization: saline (SG), adjuvant (AG) and zein associated with adjuvant (ZG). Then, a 2 mm of defect bone was performed on the right tibia, and on days 7, 14, 28 and 45 thereafter, analyses were performed. The results showed that the injection of zein reduced inflammation without impairing bone mineralization. Moreover, biomechanical tests demonstrated higher levels of maximum force (N) in ZG, indicating better mechanical resistance in relation to the others. The computerized tomography also indicated lower levels of medullary content in the ZG than in the SG, suggesting the absence of trabeculae in the medullary region in the ZG. These findings suggest that the injection of zein in previously tolerated animals may improve bone repair, leading to mechanically functional bone formation.
Enzymatically cross-linked peptide hydrogels for enhanced self-assembling capability and controlled drug release
Authors: Wang Xiujie , Dai Guoru , Cheng Bianli , Xu Jing , Xu Keming , Zhong Wenying
Published: April 2023

An ultra-short peptide derivative was enzymatically cross-linked to give self-assembled hydrogels with enhanced mechanical properties and controlled drug release profiles.
Melting of a macroscale binary Coulombic crystal
Authors: Battat Sarah , Weitz David A. , Whitesides George M.
Published: April 2023

Shear of a Coulombic crystal, due to repetitive collisions with its container upon shaking, simultaneously orders and melts the crystal.
Perylene diimide-based sensors for multiple analyte sensing (Fe2+/H2S/ dopamine and Hg2+/Fe2+): cell imaging and INH, XOR, and encoder logic
Authors: Kaur Navdeep , Kour Rasdeep , Kaur Satwinderjeet , Singh Prabhpreet
Published: April 2023

DNP has been used for the detection of Fe2+ and H2S, while DNP–Fe2+ is used for dopamine detection and DNB for Hg2+ and Fe2+ detection. The INH, XOR, and encoder logic gates and bioimaging of Fe2+ in A549 cells using DNP are demonstrated.
Carbonized loofah sponge-based solid-phase extraction of benzo[a]pyrene from fish followed by liquid chromatography-ultraviolet detection
Authors: Zhu Yaqi , Zhong Saiyi , Peng Xitian , Yu Qiongwei , Feng Yuqi
Published: April 2023

CLS was used for the first time as an SPE adsorbent for the extraction of BaP in fish. An analytical method for BaP in fish was developed and it provides an alternative way for the efficient analysis of BaP in aquatic food and can be used to ensure food safety.
Immunotoxicity of metal and metal oxide nanoparticles: from toxic mechanisms to metabolism and outcomes
Authors: Bi Jiaming , Mo Chuzi , Li Siwei , Huang Mingshu , Lin Yunhe , Yuan Peiyan , Liu Zhongjun , Jia Bo , Xu Shuaimei
Published: April 2023

Metal and metal oxide NPs may have toxic effects on the immune system through a variety of different mechanisms.
Facile synthesis of poly(disulfide)s through one-step oxidation polymerization for redox-responsive drug delivery
Authors: Zhang Ruhe , Nie Tianqi , Wang Liying , He Danni , Kang Yang , Zhang Chao , Wu Jun
Published: April 2023

A facile one-step oxidation polymerization strategy was developed to construct biodegradable poly(disulfide)s (PBDBM) for redox-responsive drug delivery with reduced systemic toxicity.
Study on antibody Fc-glycosylation for optimal effector functions
Authors: Shivatare Vidya S. , Chuang Po-Kai , Tseng Tzu-Hao , Zeng Yi-Fang , Huang Han-Wen , Veeranjaneyulu Gannedi , Wu Han-Chung , Wong Chi-Huey
Published: April 2023

A comprehensive structure–activity relationship study on antibody Fc-glycosylation has been performed using the chimeric anti-SSEA4 antibody chMC813-70 as a model.
Cu-loaded zeolites enable the selective activation of ethane to ethylene at low temperatures and pressure
Authors: Kvande Karoline , Prodinger Sebastian , Solemsli Bjørn Gading , Bordiga Silvia , Borfecchia Elisa , Olsbye Unni , Beato Pablo , Svelle Stian
Published: April 2023

Sending ethane over Cu-oxo sites in zeolites allows for the selective formation of ethylene in a stepwise reaction at mild conditions. Experimental results indicate that the reaction proceeds via the formation of ethanol intermediates.
Borenium-ion-catalyzed hydrogenation of arenes
Authors: Yang Yizhou , Xu Yuliang , Wang Huadong
Published: April 2023

Metal-free hydrogenation of arenes was achieved by using a borenium ion as the catalyst.
Single-cell multi-element analysis reveals element distribution pattern in human sperm
Authors: Tian Xiangwei , Li Xun , Liu Nian , Cui Wenbin , Zheng Lingna , Guo Yingying , Liu Yanwei , Hu Ligang , Wang Meng , Liang Yong , Yin Yongguang , Cai Yong , Jiang Guibin , Jin Lei
Published: April 2023

We report a novel analytical procedure to simultaneously quantify multiple elements of individual sperm cells. The multi-dimension data can reveal cellular heterogeneity and distribution patterns for the elements.
Recent advances in membrane crystallization
Authors: Shen Lixia , Dang Mingyan , Han Xingwei
Published: April 2023

The membrane crystallization process can be divided into membrane distillation, reaction, antisolvent, and cooling crystallization processes.
Aluminum nanotubes as an efficient catalyst for hydrogen production via thermochemical water splitting: a reactive molecular dynamics simulation
Authors: Kumar Sunil , Sahu Ranjan K.
Published: April 2023

Water splitting is the process of using energy to break down water molecules into hydrogen and oxygen.
Vibrational dynamics of liquid water in an external electric field
Authors: Ojha Deepak , Kühne Thomas D.
Published: April 2023

In our present study, we have investigated the effects of an externally applied static electric field on the vibrational dynamics of liquid water (D2O) using ab initio molecular dynamics.
Effects of silylene ligands on the performance of carbonyl hydrosilylation catalyzed by cobalt phosphine complexes
Authors: Fan Qingqing , Du Xinyu , Yang Wenjing , Li Qingshuang , Huang Wei , Sun Hongjian , Hinz Alexander , Li Xiaoyan
Published: April 2023

The effect of silylene ligand on the performance of carbonyl hydrosilylation catalyzed by cobalt complexes is presented. Different mechanisms for the hydrosilylation of aldehydes catalyzed by 1 and 2 were proposed and supported by DFT studies.
Optimized H2-evolving dye-sensitized LaFeO3 photocathodes prepared via the layer-by-layer assembly of dyes and catalysts
Authors: Xu Ximeng , Li Yingzheng , Liu Chang , Zhang Peili , Fan Ke , Wu Xiujuan , Shan Yu , Li Fusheng
Published: April 2023

Six layers of a dye and four layers of a catalyst were loaded onto the surface of LaFeO3 films via layer-by-layer assembly; the resulting photocathode exhibited a significant photocurrent for light-driven H2 generation.
Association of maternal vitamin D status with the risk of preeclampsia
Authors: Nema Juhi , Wadhwani Nisha , Randhir Karuna , Dangat Kamini , Pisal Hemlata , Kadam Vrushali , Mehendale Savita , Wagh Girija , Kulkarni Bharati , Sachdev Harshpal Singh , Fall Caroline , Gupte Sanjay , Joshi Sadhana
Published: April 2023

The aim of this study was to examine serum vitamin D concentrations from early pregnancy until delivery in women who did and did not develop preeclampsia.
Molecular mechanism of green tea polyphenol epicatechin gallate attenuating Staphylococcus aureus pathogenicity by targeting Ser/Thr phosphatase Stp1
Authors: Gao Yawen , Wang Hongsu , Li Xuening , Niu Xiaodi
Published: April 2023

In this study, we discovered that ECG, a polyphenol compound extracted from green tea, demonstrated marked anti-Ser/Thr phosphatase (Stp1) activity towards Staphylococcus aureus (S. aureus) with an IC50 value of 8.35 μM.
Microfluidic in-line dynamic light scattering with a commercial fibre optic system
Authors: Torquato Luis M. G. , Hélaine Nelson , Cui Yufan , O'Connell Roisin , Gummel Jérémie , Robles Eric S. J. , Jacob David , Cabral João T.
Published: April 2023

We report the coupling of dynamic light scattering (DLS) in microfluidics, using a contact-free fibre-optic system, enabling the under-flow characterisation of a range of solutions, dispersions, and structured fluids.
Multifunctional cobalt metal–organic framework luminescent probe for the efficient sensing of Cr2O72−, MnO4− and nucleobases
Authors: Ladhi Ritu , Rani Deepika , Singh Monika
Published: April 2023

A multi-responsive 3D Co-based luminescent MOF probe for the ultra-low detection of oxo-anions (Cr2O72−, MnO4−) and DNA and RNA nucleobases (adenine, cytosine, guanine, thymine, uracil) in aqueous media with good recyclability is reported.
DNA-embedding Schiff base molecule assemblies: an efficient biological detection approach based on clustering-triggered emission
Authors: Lv Danning , Huang Jingyuan , Li Xianyang , Cui Chunzhi , Ahn Dong June
Published: April 2023

A novel biological detection method is performed by the clustering-triggered emission of a small Schiff base molecule/single strand DNA hybrid assemblies.
Preparation of carbon coated hyperdispersed Ru nanoparticles supported on TiO2 HER electrocatalysts by dye-sensitization
Authors: Li Hong-Cheng , Ji Peng-Cheng , Teng Yang , Jia Hai-Lang , Guan Ming-Yun
Published: April 2023

A good HER catalyst C/Ru/TiO2 was prepared by the dye-sensitization method, Ru nanoparticles were uniformly loaded on TiO2, and the catalytic performance was further improved by carbon coating technology.
Recent advances in nanoscale metal–organic frameworks for cancer chemodynamic therapy
Authors: Ji Muse , Liu Hongbing , Gou Jingxin , Yin Tian , He Haibing , Zhang Yu , Tang Xing
Published: April 2023

Recent advances in nanoscale metal organic frameworks for cancer chemodynamic therapy.
Dual-inhibition of lactate metabolism and Prussian blue-mediated radical generation for enhanced chemodynamic therapy and antimetastatic effect
Authors: Li Wenting , Liu Shikai , Zhang Yangyang , Zhou Jialing , Li Rumin , Gai Shili , Zhong Lei , Yang Piaoping
Published: April 2023

A versatile nanoparticle based on the hollow structure of Prussian blue (HCLP NPs) is developed for dual-inhibition of lactate metabolism and enhanced chemodynamic therapy.
Quaternization-induced micellization of cationic glycopolymers
Authors: Chen Jing , Zheng Zhaoquan , Li Die , Guan Zhangbin , Xu Xiaoling , Shang Cenyao , Zhang Qiang , Li Guang-Zhao
Published: April 2023

Quaternization-induced self-assembly was developed as a strategy for the fabrication of sugar-containing nanoassemblies in water.
Naphthalene engineering of chemically recyclable polyesters with enhanced thermal and mechanical properties
Authors: Wang Xue-Mei , Huang Hao-Yi , Tu Yi-Min , Cai Zhongzheng , Zhu Jian-Bo
Published: April 2023

Monomer design strategy via functional substitution served as a powerful tool to improve chemical recyclability of the resulting polymers and fine-tune their thermal and mechanical properties.
Highly enhanced electrocatalytic OER activity of water-coordinated copper complexes: effect of lattice water and bridging ligand
Authors: Muthukumar Pandi , Arunkumar Gunasekaran , Pannipara Mehboobali , Al-Sehemi Abdullah G. , Moon Dohyun , Anthony Savarimuthu Philip
Published: April 2023

A water coordinated bimetallic copper complex with lattice water and shorter intermetallic distance showed enhanced OER activity.
Conformationally supramolecular chirality prevails over configurational point chirality in side-chain liquid crystalline polymers
Authors: Cheng Xiaoxiao , Gan Yijing , Zhang Gong , Song Qingping , Zhang Zhengbiao , Zhang Wei
Published: April 2023

Helicity modulation and morphology visualization of SCLCPs can be achieved through the chiral communication of the conformational supramolecular chiral units, independent of the configurational point chirality.
ItOct (ItOctyl) – pushing the limits of ItBu: highly hindered electron-rich N-aliphatic N-heterocyclic carbenes
Authors: Rahman Md. Mahbubur , Meng Guangrong , Bisz Elwira , Dziuk Błażej , Lalancette Roger , Szostak Roman , Szostak Michal
Published: April 2023

We report the synthesis, structural characterization and catalytic activity of ItOct (ItOctyl), C2-symmetric, higher homologues of ItBu. Replacement of the t-Bu side chain with t-Oct results in the highest steric volume of N-alkyl N-heterocyclic carbenes reported to date.
Molecular engineering of locked alkyl aryl carbonyl-based thermally activated delayed fluorescence emittersviaa cascade C–H activation process
Authors: Zhang Yunxi , Huang Zhengmei , Yang Yudong , Liu Jiahui , Tian Yang , Bin Zhengyang , You Jingsong
Published: April 2023

Molecular engineering of structurally nontraditional locked alkyl aryl carbonyl-based TADF emitters is presentedviaa cascade rhodium-catalyzed C–H activation process.
Theory of self-coacervation in semi-dilute and concentrated zwitterionic polymer solutions
Authors: Budkov Yury A. , Brandyshev Petr E. , Kalikin Nikolai N.
Published: April 2023

Based on the random phase approximation, we develop a molecular theory of self-coacervation in zwitterionic polymer solutions.
Dual enzyme-like Co–FeSe2nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy
Authors: Zhang Jingge , Ha Enna , Li Danyang , He Shuqing , Wang Luyang , Kuang Shaolong , Hu Junqing
Published: April 2023

Co–FeSe2nanozymes were designed which exhibited synergistic catalytic-photothermal anti-tumor performance. A ‘ferroptosis–apoptosis’ dual pathway was found for Co–FeSe2nanozymes to promote cancer cell death.
Modulation of hyperthermic and relaxometric responses of magnetic iron oxide nanoparticles through ligand exchange provides design criteria for dual-functionality
Authors: Aluri Esther Rani , Shingte Sameer D. , McKiernan Eoin P. , Ferguson Steven , Brougham Dermot F.
Published: April 2023

Changes in hyperthermic and MRI efficacies of magnetic nanoparticle suspensions following ligand exchange/phase transfer and in the gel phase reveals how the responses are determined by moment dynamics and particle and solvent diffusion.
Correction: Heads or tails: investigating the effects of amphiphile features on the distortion of chiral nematic liquid crystal droplets
Authors: Honaker Lawrence W. , Schaap Jorik , Kenbeek Dennis , Miltenburg Ernst , Deshpande Siddharth
Published: April 2023

Correction for ‘Heads or tails: investigating the effects of amphiphile features on the distortion of chiral nematic liquid crystal droplets’ by Lawrence W. Honaker et al., J. Mater. Chem. C, 2023, 11, 4867–4875, https://doi.org/10.1039/d2tc05390j.
Brainprint based on functional connectivity and asymmetry indices of brain regions: A case study of biometric person identification with non‐expensive electroencephalogram headsets
Authors: Ortega‐Rodríguez Jordan , Martín‐Chinea Kevin , Gómez‐González José Francisco , Pereda Ernesto
Published: April 2023

Brain‐computer interface applications for biometric person identification have increased their interest in recent years since they are potentially more secure and more difficult to counterfeit than traditional biometric techniques. However, it is necessary to consider how brain waves are acquired for this purpose, not only in terms of efficiency but also of practical comfort for the user and the affordability degree of the biosignal acquisition device so that their everyday application can become a realistic possibility. In this context, this paper presents the capabilities of using a non‐expensive wireless electroencephalogram (EEG) device to extract spectral‐related and functional connectivity information of brain activity. The proposed method achieved a sufficient biometric identification with two datasets of 13 and 109 subjects when comparing the performance of a sizeable classification algorithm set. In addition, a novel feature in EEG biometric identification, called asymmetry index, is introduced here. Furthermore, this is the first study in this field to consider the effect of the time‐lapse between different recording sessions on the system's behaviour when using a low‐cost EEG device with identification accuracy rates of up to 100%.
Analysis method of voltage quality in distribution station area based on high‐speed power line carrier and GA‐ANN in smart grid
Authors: Deng Hanjun , Yang Shuai , Huang Rui , Liu Mouhai , Ma Yeqin , Xie Yinghai
Published: April 2023

Aiming at the problem that most of the existing methods cannot obtain and accurately analyse the voltage quality of distribution network in time, a method for monitoring and analysing the voltage quality of distribution station area based on high‐speed power line carrier under the power Internet of Things (PIoT) architecture in smart grid is proposed. Firstly, based on the PIoT architecture, a monitoring system for the distribution station area is designed, which realises the reliable monitoring of the voltage in the station area through the information interaction of the sensing layer, the network layer, the platform layer and the application layer. Then, the high‐speed power line carrier is used to realise the rapid monitoring and collection of the station data, which improves the quality of basic data, and the principal component analysis method is used to extract the voltage quality characteristics and reduce the dimension. Finally, genetic algorithm (GA) is used to optimise the training of artificial neural network (ANN) to obtain the best improved GA‐ANN network model. It is used to analyse the voltage quality feature set, which further improves the accuracy of obtaining voltage quality anomalies and related reasons. Based on the established distribution station area, the proposed method is experimentally demonstrated. The results show that the accuracy of voltage quality anomaly monitoring and analysis exceeds 99.5% and 97% respectively, and the average accuracy of low‐voltage cause analysis reaches 97.83%, laying a theoretical foundation for building a strong distribution network.
Investigation of the rotation number of a fish feed distribution device disc apparatus
Authors: Astanakulov Komil , Kurbonov Fazliddin , Isakova Farida
Published: April 2023

In fish farms established in Uzbekistan, granulated feeds are widely used for feeding fish, but they are distributed mainly by hand. In countries where fisheries are well developed, automatic, semi-automatic, and mechanical feed distribution devices are used to distribute food to fish in lakes where fish are grown, and it gives good results. Taking this into account, it is important to develop a device that distributes food for fish in Uzbekistan and to base its construction scheme on the technological work process. The influence of the number of rotations of the fish feed distribution device disk on the unevenness of the feed distribution and the distribution distance was studied. Based on this, a device for distributing granular feed to fish was developed and the number of revolutions of its feed distribution disc was investigated. When the rotation number of the feed distribution disc was changed from 750 r/min to 1750 r/min, the distribution radius of the feed increased and the unevenness decreased, and when the rotation number of the disc was 1500 r/min, the distribution radius of the feed was 9.6 m and the distribution unevenness was more than 20% it was determined not to be.
Influence of bee family care on honey productivity in hives of different constructions
Authors: Kakhramanov Boymakhmat , Akmalkhanov Talat , Soatov Utkir
Published: April 2023

It is of great importance to design and manufacture light and cheap hives that are easy to operate and easy to operate in normal beekeeping conditions. Several types of hives are used depending on the breed, origin, lifestyle and climate of the bees. In the warm climate of Uzbekistan, the most commonly used hive in beekeeping is the bee hive. There are mainly three types of hives used in beekeeping, i.e. bed hives, double hives and multi-storey hives. Studying which types of nests to use in the hot climate of Uzbekistan and their effect on family productivity is one of the urgent issues of today. The natural climatic conditions of Uzbekistan have a favorable opportunity to increase the productivity of agricultural crops, feed bee colonies based on modern advanced technologies, and increase the production of bee products. In this article, keeping bee families in hives of different constructions in the conditions of the Tashkent region, studying the effect on the productivity of families, determining the suitable bee hive suitable for hot climate conditions is studied.
Effective methods of bee pest control
Authors: Kakhramanov Boymakhmat , Isamukhamedov Solikh , Donaev Khusniddin
Published: April 2023

Phyllants are similar to ordinary wasps, but slightly larger than them, the body is 1.2-1.6 cm long, very mobile, the abdomen is yellow, surrounded by dark transverse lines, the legs are yellow. The head and mouth are quite large and dark. Male philanthemums are smaller than females, they only land on flowers. Female philanthropists build upright nests in sun-drenched sandy areas with crossways connecting them and lay a single egg in each. The female brings 8-10 dead bees to feed the maggots. Philanthes catch bees in flight, kill them by stabbing the stinger in the chest, and feed on their hemolymph and nectar. In favorable conditions, it multiplies very quickly. Each female philant builds 25-35 nests and active in hot weather.In our studies, adaptation and breeding of Kraina (Apis mellifera carnica) and Carpathian (Apis mellifera carpatica) bees brought from abroad to natural climatic conditions of Uzbekistan, pests of veiled bees found in natural climatic conditions of Uzbekistan and effective methods of combating them were determined. The scientific justification of the influence of pests on the growth and development of bees, as well as productivity, was studied for the first time on the basis of comparative experiments.
Method of obtaining pure organo-mineral fertilizer and its ecological investigation of the influence on soil fertility
Authors: Begmatov Ilkhom , Nurov Rejepnur , Amanov Kadyr , Reyimov Dayanch , Atayev Serdar
Published: April 2023

The article discusses the soil-improving properties of an environmentally friendly organo-mineral fertilizer (OMF) obtained on a scientific basis at the Institute of Chemistry of the Academy of Sciences of Turkmenistan. The main goal of the study is to obtain an environmentally friendly OMF from chicken manure, which accumulates in large quantities on poultry farms and pollutes the environment, as well as to study the effect of the resulting fertilizer on the humus composition of the soil. Broiler chicken manure, microbiological preparation Nourivit Plus and phosphorite ores from the deposit of the Magdanly-Kugitan region of the Durnaly site were used as raw materials and their chemical compositions were determined (humidity, ash content, total organic matter, total nitrogen, phosphorus, and potassium and pH environment). The composition of bird droppings was found to contain a sufficient amount of organic substances and such important nutrients as nitrogen, phosphorus, and potassium. Under laboratory conditions, a scientific method for obtaining an environmentally friendly OMF was studied. Chicken manure used as raw material was neutralized from weed seeds and helminth eggs. Processing on the basis of waste-free technology of waste generated in poultry farms, an environmentally friendly, cost-effective, soil-improving OMF was obtained. The soil-strengthening properties of the obtained OMFs were studied at the Turkmen Agricultural University named after SA Niyazov on 3 plots of agricultural land measuring 1 x 6 meters. Samples were taken for analysis from each of the 3 soils before and after the application of OMF. An agrochemical analysis of the soil and a quantitative analysis of substances soluble in it were carried out. As a result, the elemental and humus composition of soil samples was determined before and after fertilization, and as a result it was proved that it is possible to increase the amount of humus in the soil from 0.12% to 2.17%.
Risk identification and assessment of irrigated land erosion in Tashkent province, Uzbekistan
Authors: Kuchkarova Nodira , Khakberdiev Obid , Makhkamova Aliya
Published: April 2023

Irrigated fields are important assets for agricultural development since they supply vital food and fiber to people all over the world. These areas are, however, also susceptible to erosion, which can result in the deterioration of the soil and a loss in production. It is crucial to identify and evaluate the erosion risk in irrigated areas in order to maintain sustainable agriculture and guarantee the resources' long-term availability. The objective of this study is to create a thorough system for recognizing and evaluating the erosion risk in irrigated areas. The methodology will take into account a number of variables, including climate, topography, soil properties, land management techniques, and other pertinent variables that affect the risk of erosion. To identify and assess the erosion hazard of irrigated lands of the farm named after. S. Rakhimov of the Chinaz district of the Tashkent province, Uzbekistan, we laid 4 key sites, depending on the steepness, length, slope exposure and sown crops, and mapped the soils at a scale of 1:1000. At each site, profiles were laid that sequentially cut all the elements of the slope, from the top to the plume, and all soil varieties found on this slope. In the alignment of the profiles, on all elements of the relief, 25 reference sections were laid, characterizing all soil varieties in this area. To identify the boundaries of the contours of individual soil varieties, a series of hollows and pits were laid. Soil morphology was studied on the reference sections, and soil samples were taken according to genetic horizons for subsequent analysis.
Improving the efficiency of extinguishing forest grass-roots fires with knapsack forest fire extinguishers
Authors: Zhuravleva Larisa
Published: April 2023

The most effective means of fighting forest fires is the timely detection of fires, monitoring and patrolling of recreation areas, extinguishing of unquenched fires. The purpose of the research is to increase the efficiency of extinguishing forest grass-roots fires with knapsack forest fire extinguishers based on constructive and technical solutions that ensure economical use of fire extinguishing agents. The article presents studies of the characteristics of sprayed water, water vapor, affecting the effectiveness of extinguishing. Optimal ratios of the design parameters of the developed knapsack forest fire extinguishers are given. With a short-term exposure to steam on the hearth, diffusion combustion stops. The condition for stopping the burning of wood is the cessation of flame combustion and cooling of coals formed during combustion to a temperature below the pyrolysis temperature, i.e. below 200 ° C. In the case of heterogeneous combustion, the effect of a jet of water vapor on the centers of smoldering is ineffective. To cool the diffusion flame torch, a steam consumption of 1.9 kg per kilogram of wood is required. The water vapor consumption required to dilute the gaseous pyrolysis products formed from one kilogram of wood is about 7 kg. The presented experimental studies confirm the effectiveness of sprayed water and steam as independent extinguishing agents and means of creating support strips. To achieve a critical level of moisture content, the thickness of the condensate film should be at least 0.1 mm. The effective velocity of the steam source is about 1.5-2.5 km/h.
Phytochemical composition of Humulus Lupulus L. in ontogeny under different treatments
Authors: Al Hussein Dalal , Almugrabi Esraa , Mostyakova Antonina , Timofeeva Olga
Published: April 2023

Wild hop (Humulus lupulus L.) is a double-headed perennial climbing plant that belongs to the Cannabaceae family. Hops contain many biologically active compounds possessing powerful antimicrobial, antioxidant and antifungal activity, due to which its original use was for medicinal purposes and only later began to be used in beer production. The aim of the work was to identify the effects of growth regulators (hibbersib and epin-extra) and biofertilizer (powder) on the content of soluble phenolic compounds, flavonoids, tannins, carotenoids, vitamins C and B, protein and sugars in plants of common hop (Humulus lupulus L.) during ontogenesis. Root cuttings of hops were planted in the beginning of May 2022 in protected ground under laboratory conditions. In the second variant rootstock were potted in soil with 10 g/kg powders; in the third variant rootstocks were treated with hibbersib (666.6 µg/l) by spraying; in the fourth variant also, rootstocks were treated with epin-extra (500 µl/l) by spraying. After 4 weeks, all variants were transplanted to the open field. The samples for analysis (leaves) were taken 4, 8, 12 and 16 weeks after planting in the open ground, the average night temperatures were +160C, +240C, +140C and +70C, respectively. Phytochemical composition of leaves was determined by spectrophotometric method. In control plants the content of phenolic compounds and vitamin C reached the highest values in the twelfth week after planting. The synthetic growth regulators (epin-extra and hibbersib) and the biofertilizer (pudrete) were shown to change the phytochemical composition of the hop plants to different extents. Powdertet increased the vitamin and protein content to a greater extent whereas growth regulators increased the content of phenolic compounds and sugars, particularly under the influence of hibbersib.
Legal and regulatory institutions integration in environmental policy of the Russian Federation
Authors: Studenikina Svetlana , Moskaleva Tatiana , Alyokhina Ekaterina , Matveeva Olesya , Gluschenko Dmitry
Published: April 2023

The legal regulation of environmental policy in the Russian Federation is carried out by a number of institutions and organisations, the management process of which in practice proves to be fragmented and uncoordinated. The functioning of this system, which lacks internal unity, leads to larger crises at the social, economic, and international levels. In today's increasingly globalised environment, environmental law seeks new ways of consolidation and international cooperation, which can only be achieved through the internal integration of legal institutions. Examining the shortcomings of the existing legal system, identifying ways to address them, and identifying mechanisms for integration will lead to positive effects in addressing environmental issues, both nationally and internationally.
Developer status assessment based on its aggregate capacity estimation
Authors: Voronina Natalia , Steksova Svetlana
Published: April 2023

Investment and construction activity development entailed not only the improvement of existing systems and approaches to the assessment of the state of participants of this process, but also the emergence of new areas of analysis based on a comprehensive space-oriented structure of both the project itself and its environment. The methods of the complex estimation of the investment and construction project condition which takes into account not only the design risk and the stage of the project realisation but also the financial and economic condition of the participants of the investment and construction activity, first of all the developer. The estimation of financial and economic conditions of the developer is suggested to be carried out on the ground of aggregate potential that characterises the possibilities to achieve the objectives set before the enterprise and solve the current problems taking into account resource constraints and factors of the internal and external environment. Consideration of the aggregate potential of the enterprise as a complex multilevel system that covers all subsystems and organisational and technological processes, allows developing a comprehensive and objective assessment of the financial and economic condition of the developer that allows identifying reserves to further improve the efficiency of its activities.
Russian regional labour law on social partnership and labour protection
Authors: Yakovenko Nina , Khabibullina Anna
Published: April 2023

This article is devoted to the problems of formation and systematisation of labour legislation in key areas such as social partnership and labour protection. Based on the comparative legal characteristics of the regulatory legal acts of different regions in the field of labour, the conclusion is made about the need for a unified approach to the development of legislation in this area, the inadmissibility of duplication of federal normative acts, taking into account the specifics of the regions and the adoption of new legislative acts. The authors have developed the main directions for the systematisation of labour law and lawmaking in the regions, taking into account the current situation.
Evaluation of the quality and safety of cows' milk when using the mineral elements
Authors: Sufyanova Liliya , Smolentsev Sergey , Kislitsyna Nadezhda , Aleev Damir , Malanev Andrey , Khalikov Kadria , Yamalova Guzaliya , Gabitova Gulnara , Valiev Almaz
Published: April 2023

A successful feeding program should solve the following problems: achieving planned milk production, increasing dry matter intake and improving ruminal microbiota. As an integral part of the diet, feed additives have an impact on the animal's body, which is expressed, for example, in an increase in average daily weight gain, a decrease in conversion, an improvement in metabolic metabolism and so on. However, it should be noted that feed additives alone do not guarantee of high productivity or profitability of milk production. The purpose of these studies was to evaluate the effect of the multicomponent feed additive Felucen on the sanitary quality and safety of cows' milk. The studies were conducted on the basis of training and experimental farm, where two groups of dairy cows, 40 heads each, were formed according to the principle of analogues. All cows of both groups received the basic diet accepted on the farm. Additionally, the first group received Felucen feed additive at the rate of 5 g per 1 kg of body. Analysis of the milk composition and productivity was carried out on the 10th, 30th, 60th and 90th day. The use of Felucen provided an increase in the milk productivity of cows by 11% and an increase in the quality indicators of milk: the mass fraction of fat increased by 0.11%, protein - by 0.21%, lactose - by 0.20%.
Ensuring safe evacuation of people from nightclubs
Authors: Parfyonenko Alexander
Published: April 2023

The paper considers the problems of standardisation of evacuation routes and exits in nightclub buildings. The absence of regularities of people's movement in such buildings in the normative and research literature does not make it possible to estimate adequately the projected and existing planning decisions from the point of view of providing the safe evacuation of people, but also the value of individual fire risk. The analysis of fires has shown that the main cause of loss of life in a nightclub fire is untimely evacuation due to the accumulation of human traffic in front of the building exits. In order to determine the parameters of the flow of people, there were conducted preliminary field observations in nightclub buildings. Statistical analysis of the data obtained made it possible to establish the dependence of the movement of people up and down the stairs, horizontal path and through the doorway. The results of modeling of people evacuation have shown significant differences between the data presented in the methodology of assessment of fire risk and the data obtained in the research. The data obtained allow a reliable assessment of the criteria of safe evacuation of people in the design and operation of nightclubs, as well as the calculation of individual fire risk.
Beliefs, attitudes, values and engagement of generation X, Y employees
Authors: Daver Diana
Published: April 2023

This study starts with employee opinion survey, which is a measurement tool of employee engagement and satisfaction. The result of the survey, performed among 1480 employees of international construction company, points at certain targets for improvement in well-being field. We strove to find a correlation within least contented employees, between such factors as their seniority status in the company, gender, age and their low satisfaction, thus we found out that generation X employees are more satisfied (9% more) and as a result more engaged in the company culture than Y employees. This article reveals the reasons of this difference in satisfaction level between employees of two generations. Our first hypothesis was that shift in value orientation caused inconsistency with corporate culture, but after having used method of values ranking (system of «Life Meanings» by V. Yu. Kotlyakov) for a group of 620 employees of both generations, we had to accept that our hypothesis was only partially true and value changes in two generations were not dramatic. Our second hypothesis stated that deeper changes in reality perception like beliefs and self-concept could lead to lower satisfaction of Y generation employees with their work. We supposed that these deeper changes include beliefs as the basic elements of any complicated construct. We applied method of collectivism and individualism orientation measuring by Pochebut L. G to the group of 248 respondents of both generations. The outcome of this study shows that generation X employees’ beliefs reflect collectivism orientation and beliefs of the generation Y employees reflect individualism in 50% of the sampling.
Enhancing environmental education for students by designing regional weekend hikes
Authors: Tinkova Zinaida , Tinkov Ivan
Published: April 2023

The article deals with the main problems related to environmental education of students. The analysis of activities aimed at environmental education is given. The plan of measures to enhance environmental education, which included practise-orientated tasks that improve environmental literacy and motivation of students, consisted of activities divided into components: environmental literacy activities; environmental planning activities; project implementation activities. The plan was implemented at the Faculty of Physical Education and Sports of Orel State University named after I.S. Turgenev. The diagnostic toolkit, questionnaires, and expert assessments have proved the effectiveness of the activities. Diagnostics included the evaluation criteria: cognitive, value, activity, and creative components. The study showed that the introduction of additional activities, such as the design and implementation of weekend hikes, increases the level of environmental education.
Institutional features of the regulation of investment activities of an environmental orientation
Authors: Makhosheva Salima , Kandrokova Marina , Yandieva Lyudmila
Published: April 2023

The article presents a methodology for the formation of a system for early recognition of signals that characterize the occurrence of environmental and economic problems and the need to develop and implement environmental investment projects at industrial enterprises in the region, including a set of methods for obtaining, processing and analyzing information in the form of a sequence of five stages. The first stage is the search and primary processing of information. The second stage involves recognizing the position of the industrial enterprise and identifying problems. At the third stage, it is necessary to identify the strengths and weaknesses of the competitive position, the opportunities and threats of investment in environmental protection. The fourth stage makes it possible to determine the most likely scenario for the investment activity strategy. The essence of the fifth stage is the formation of a program to improve the mechanisms of institutional regulation of investment activity at all levels of management. An analysis of the strategic potential can be carried out in the form of an analysis of strengths and weaknesses, opportunities and threats only using the factors influencing environmentally oriented investment activities. In the process of strategic analysis, the degree of readiness of an industrial enterprise, all industrial enterprises in the region to implement the new requirements of ISO 9001:2000 quality management, ISO 14001 environmental management and the developed international standard ISO 19011, which combines the requirements of the two previous management standards, was clarified. The article shows that strategic analysis and environmental audit are interrelated and require simultaneous strategic control.
The development of the application for support the intellectual analysis of texts of the humanities and socio-economic cycle
Authors: Kotsyuba Igor , Sazhneva Lioubov , Shikov Alexey , Shtennikov Dmitry , Zhirkova Galina , Triandofilidi Ivan
Published: April 2023

The article is devoted to the consideration of the problems of didactic design of teaching materials by a teacher of disciplines of the humanities and socio-economic cycle associated with the study of a significant amount of information from various sources, the need to select a number of literary sources taking into account their specifics for different educational tasks and types of educational activities, as well as ranking the most important didactic units for the formation of working programs of disciplines. The possibilities of using automation tools for the analysis of text materials are revealed, which will allow a teacher engaged in the didactic design of a particular discipline to conduct a syntactic analysis of methodological materials, significantly reduce the complexity of this process when developing, making changes and adapting courses of social and humanitarian orientation. As a result of the analysis of the subject area, the authors determined a list of functional requirements, based on which the results of the physical and logical design of the system were presented, including a database model, system architecture, as well as a deployment diagram using an object-oriented modeling language.
Marketing tools for the digitalization of trade
Authors: Krasyuk Irina , Yanenko Marina , Asfondiarova Irina , Illarionova Ksenia , Katkova Nina , Muhutdinov R.R.
Published: April 2023

The Digital Revolution had a significant impact on the sphere of circulation in general, and on trade in particular. The use of online marketing communication tools allows vendors to target their offers and select information or marketing messages based on the individual interests and behavior of consumers. Analyze the impact of digitalization on the marketing activities of trading companies. As a result, the author's approach to the digitalization of trading companies has been developed. This involves the construction and adaptation of the marketing structure in trading companies, which depends on the range of consumer values. The direction for further scientific research by the authors involves studying the impact of marketing tools on the digital processes of trading companies.