bluuebunny/crossref_metadata_2025 huggingface dataset:
Static Voltage Stability Analysis of Renewable Energy Integrated Distribution Power System based on Impedance Model Index
Authors: Wang Yang , Cai Yongxiang , Li Wei , Tan Zhukui , Song Zihong , Li Yue , Bai Hao , Liu Tong
Published: January 2024

Static voltage stability has become one of the significant risks faced by large-scale renewable energy integration. However, traditional methods for static voltage stability analysis are often overly complex. This paper constructs an equivalent impedance model for renewable energy integrated distribution power systems, proposing a static voltage analysis method for renewable energy integrated distribution power systems based on impedance model index. This method has been verified to be applicable not only to renewable energy single-infeed system but also to multi-infeed system. Furthermore, an analysis is conducted on the influence of the integration capacity, location of renewable energy, and the topology of networks on impedance model index, indicating that a higher impedance model index corresponds to greater static voltage stability margins in the system. Hence, during the planning of renewable energy integration, the plan with the highest impedance model index should be selected. Finally, the accuracy of the analysis methods and conclusions in this paper was validated based on the IEEE 14-node system.
Solid-Liquid Equilibrium Study of Binary System Saturated Fatty Acid in Short Chain Alcohols
Authors: Setyawardhani Dwi Ardiana , Majid Difa Aulia , Plawi Rudhang Suryoadhi Suryatmoko
Published: January 2024

Unsaturated fatty acids are potential to be used for preventing degenerative diseases and developing brain function in babies. Separation of unsaturated fatty acids from saturated fatty acids efficiently achieved by urea complexation fractionation method. It is considered to be the simplest, most efficient, and lowest cost method. This study aimed to optimize urea complexation for increasing PUFA concentrations by determining solid-liquid equilibrium data of saturated fatty acids in short chain alcohols. In this study, there were two types of short chain alcohol, methanol and ethanol, in various concentrations (99,7%; 95%; 88%; 76% w/w) towards the solubility of saturated fatty acids, palmitic and stearic acid (PA and SA). PA and SA dissolved in various concentration of methanol and ethanol to get homogeneous solutions. When solid SFA disappeared by heating the solution, or first formed by cooling the solution, the temperature was determined as the solid-liquid equilibrium temperature. The results showed that the best composition of solvent within high solubility level is ethanol 95% and methanol 99,7% over palmitic acid because it can dissolve at room temperature and below 0.01 mole fraction.
Teacher's emotional approach to students in Monsieur Lazhar film and film La Cour de Babel
Authors: Yohana Maria Monalisa  , Yunilis Andika  , Dian Savitri
Published: January 2024

This research aims to determine the types of teacher's emotional approach to students in the film Monsieur Lazhar and the film La Cour de Babel. This study uses a descriptive qualitative approach which explains the types of emotional approaches according to Chevalier in his book entitled Faire Face Aux Emotions: Pour Gérer Au Quotidien Conflits, Stress, Agressivité (2007). There are six (6) types of emotional approach: 1) Recevoir 2) Supporter 3) Permettre 4) Aider 5) Apaiser and 6) Reparer. Then it is summarized again into four (4) types of emotional approaches: 1) Recevoir 2) Supporter et Aider 3) Permetre and 4) Asurer. Data analysis techniques in this study used data analysis techniques from Miles & Huberman which consisted of four (4) stages: 1) data collection, 2) data reduction, 3) data presentation and 4) conclusion/verification.

The amount of data obtained from the results of the analysis is thirty eight (38) data contained in the conversations between teachers and students in the film Monsieur Lazhar and the film La Cour de Babel. The most common type of emotional approach was found in Asurer with nineteen (19) data, Supporter et Aider with nine (9) data, then Permettre with seven (7) data, and Recevoir with three (3) data.
Prinsip kerjasama dalam wawancara di acara televisi “Quotidien”
Authors: Armry Zai Saga , Subur Ismail  , Yunilis Andika
Published: January 2024

Penelitian ini bertujuan untuk memerikan jenis-jenis maksim prinsip kerjasama menurut teori Grice (1989) yang digunakan dalam wawancara di acara televisi “Quotidien” edisi 07 September 2021. Teori utama yang digunakan dalam penelitian ini adalah teori prinsip kerjasama yang dikemukakan oleh Grice. Metode penelitian yang digunakan dalam penelitian ini adalah metode analisis isi. Kegiatan analisis yang dilakukan adalah mengumpulkan data dengan menonton video sumber data, mengklasifikasikan data berdasarkan penggunaan maksim prinsip kerjasama, dan menganalisis penggunaan maksim prinsip kerjasama berdasarkan teori utama.         

Hasil penelitian menunjukkan adanya 30 data penggunaan maksim prinsip kerjasama Grice. Adapun jenis maksim yang ditemukan adalah maksim kualitas, maksim kuantitas, dan maksim relevansi. Penggunaan maksim prinsip kerjasama didominasi oleh penggunaan maksim kualitas dengan jumlah 14 peristiwa tutur, penggunaan maksim kuantitas dengan jumlah 8 peristiwa tutur, lalu penggunaan maksim relevansi dengan jumlah 2 peristiwa tutur. Adapun penggunaan maksim prinsip kerjasama Grice yang tidak ditemukan adalah jenis penggunaan maksim cara.
Pengembangan media pembelajaran berbicara bahasa Prancis berbasis video pada siswa kelas XI SMAN 14 Jakarta
Authors: Tasya Ayu Safira  , Wahyu Tri Widyastuti  , Dian Savitri
Published: January 2024

The purpose of this research is to develop French learning video media on speaking skills for grade XI. This research uses the research and development (R&D) method with the ADDIE model (Mulyatiningsih, 2016) which consists of 5 stages, this research only carried out 3 stages, namely analysis, design and development. This is due to the limited time available in the research. The learning video media was made based on the results of the needs questionnaire of students of class XI IPS 1 at SMAN 14 Jakarta, the results of interviews with French teachers and the results of classroom observations. This research produces French learning videos for class XI high school that can be

accessed easily through the youtube channel. In the process of making the video, the researcher used VN and Canva Pro applications. This learning video consists of 2 videos where in video 1 using inviter quelqu'un, accepter et refuser l'invitation material lasts 8 minutes and in video 2 with féliciter quelqu'un material lasts 5 minutes. In each video there are illustrations and also some small exercises to train students' speaking skills. In addition, in the description column there is an exercise link that is directly connected to learningapps. This learning video has been validated by material experts and media experts with very feasible results with a note of making some improvements and adding some components to the video. After making improvements and additions according to the experts suggestions, this learning video media is ready to be tested in the field.
transducción de la novela gráfica al cine: el caso de «Buñuel en el laberinto de las tortugas»
Authors: Rosales García Cristina
Published: January 2024

El presente artículo tiene como objetivo, por un lado, exponer el principal tópico y prejuicio existente en torno a las transducciones cinematográficas, la fidelidad, y esa supuesta superioridad del texto literario frente al texto fílmico para, posteriormente, desmontarlos; y, por otro lado, realizar un breve análisis comparatista, sin caer en jerarquías, entre la novela gráfica Buñuel en el laberinto de las tortugas de Fermín Solís y su transducción homónima a manos de Salvador Simó. Asimismo, se hace un recorrido por la historia real que inspiró la novela gráfica de Solís: el rodaje del documental Las Hurdes, tierra sin pan (1933) de Luis Buñuel.
Heather Christle, «El libro de las lágrimas», traducción de Magdalena Palmer, Madrid, Tránsito, 2020
Authors: García Mesa Valeria
Published: January 2024

Reseña bibliográfica.
Mujeres nigerianas negociando ideales de belleza, poder y amor en la serie web «Skinny Girl in Transit»
Authors: Cruz Gutiérrez Cristina
Published: January 2024

A pesar de que históricamente diferentes culturas africanas se han caracterizado por apreciar los cuerpos voluminosos, la creciente influencia de los estándares de belleza occidentales ha cambiado la percepción colectiva de los cuerpos de talla grande (Fausat y Ayodele, 2017). A la luz de diversos debates sobre las representaciones de cuerpos no normativos en las narrativas románticas contemporáneas, este artículo explora la tensión entre las percepciones habituales y contemporáneas de dichos cuerpos al explorar los conflictos de la heroína «de talla grande» de la serie web romántica nigeriana Skinny Girl in Transit (2015-presente). Los esfuerzos de Tiwa por perder peso reflejan su búsqueda de estabilidad romántica, mientras negocia construcciones contradictorias sobre su cuerpo. Tiwa representa el frágil equilibrio entre seguir las leyes tradicionales y cumplir nuevas expectativas en materia de belleza para mantener a un hombre a su lado. Skinny Girl in Transit involucra a sus espectadores en esta discusión a través de interpelaciones directas e, indirectamente, a través de su programa de radio, The Gist, donde habla sobre el trabajo, la familia y el amor. A través de The Gist, Tiwa expresa cómo las contradicciones culturales con respecto al tamaño corporal afectan no solo la autoestima de las mujeres nigerianas sino también sus oportunidades profesionales a la hora de promocionar o ser contratadas. El hecho de que Tiwa comparta su experiencia personal se explorará como un símbolo de su rol de mentora con el que su audiencia interactiva aprende a compartir sus preocupaciones con sus compatriotas nigerianas. De esta forma, el objetivo es demostrar que la discusión de Tiwa sobre sus ansiedades personales en la esfera pública fomenta un sentido de «participatory culture» (Jenkins, 2009: xi) entre su audiencia. The Gist se analizará como un espacio seguro que fomenta un sentido de camaradería y conexión social que, en última instancia, impulsa un pensamiento crítico hacia las leyes sociales nigerianas y las prácticas que socavan los derechos de las mujeres del país.
Implikasi Sertifikasi Halal terhadap Perkembangan Industri Halal di Indonesia
Authors: Yuningsih M A. Alfira , Putri Riska Erfiana , Jubba Hasse
Published: January 2024

The globalization of halal certification bodies in numerous nations indicates that halal issues are on the rise, which bodes well for the industry's expansion prospects. The purpose of this article is to examine the ramifications of halal certification on Indonesian industries, with a specific focus on the culinary and tourism sectors. By conducting a comprehensive literature review and employing a descriptive qualitative methodology, this research compiled data from pertinent scholarly journals, books, periodicals, and electronic media, including the official websites of the LPPOM-MUI and BPJPH assembly. The results of the study underscore the favorable consequences that halal certification can have on the development of the halal sector and the economy of Indonesia. In addition to providing consumers with information and protection regarding the halal status of products, halal certification serves as a mechanism for conducting business in accordance with Sharia principles. Acquiring halal certification confers a distinct competitive advantage upon businesses, bolstering consumer trust and generating amplified advantages. Moreover, this facilitates the government's efforts to stimulate the Indonesian economy and gain access to the worldwide halal food market. It is established that halal certification increases demand for halal products, thereby solidifying the halal industry's position as a major participant on the international stage. While the present article centers on the intersection of halal cuisine and tourism, additional extensive research is necessary to cover a multitude of aspects pertaining to the halal sector.
Heretical Sects': Mediation and Mediatization on New Media
Authors: Inayah Sitti Syahar , Madani Abubakar Idham , Bunyamin Bunyamin , Amirullah Amirullah
Published: January 2024

Efforts to spread deviant sects are now easier to reach all groups. This is due to the development of new media. Da'wah in new media can be done by anyone. One of the negative impacts of new media is the difficulty in distinguishing hoax information. In the context of spreading religious beliefs or beliefs that are considered heretical, now is the right moment. They can freely spread their ideas either with a clear identity or with a disguised identity. Communication media is used as a distribution channel as well as a tool for transformation. For this reason, this research aims to describe the mediation and mediatization of teachings or understandings that are considered heretical in new media, especially YouTube.

This study used a qualitative approach with content analysis methods. The unit of analysis is a video shared by pilgrims Salamullah through the YouTube platform. Researchers perform mining data on the internet that has been available. The videos were analyzed using the multimodality method.

The findings of this study are that there is a process of mediation and mediatization carried out by adherents of the Salamullah deviant sect. In the mediation process, the YouTube account is used as a channel to transmit ideas about their beliefs. As for mediation, it can be seen in the transformation of cognition in netizens. In addition, it was also found that in the user-generated media approach, cult followers become contributors or creators on their YouTube accounts.

At the level of cognition, the changes in perception and negotiation of the meaning of heretical teachings can be formed. Indonesian culture which tends to accept new things will encourage adherents of heretical sects to use the media as a channel for conveying messages. It is this transformation that society and religious institutions must be aware of.
The Philanthropy of Coastal Society: The Challenge and Strategy of Komunitas Jumat Berkah Muara Pantuan
Authors: Munthe Fredy Torang Widiyanto
Published: January 2024

The philanthropic activities undertaken by various nonformal religious organizations in Indonesia have been experiencing significant growth. One such organization is the Komunitas Jumat Berkah Muara Pantauan (KJBMP). This study aims to examine the strategies employed by KJBMP in conducting philanthropic efforts within the coastal community of Muara Pantauan, East Kalimantan, and to identify any obstacles encountered in implementing these strategies. This research employs a descriptive-qualitative methodology, utilizing in-depth interviews with KJBMP administrators. The author also participated in one year of participatory observations within the Muara Pantauan coastal community. Data were analyzed using a thematic approach based on Anheir's concept of charitable philanthropy categorization. Findings indicate that KJBMP utilizes a charitable strategy in its philanthropic efforts in the Muara Pantauan coastal region. However, KJBMP has also recently begun implementing economic development strategies to promote self-sufficiency promote self-sufficiency within the disadvantaged community of Muara Pantauan.
The MCCC Volunteers' Legacy of Approaches for Combating COVID-19
Authors: Hayati Afita Nur , Akhyar Ramadiva Muhammad , Aini Amalia Nur , Setyowati Dina Lusiana , Yatini Yatini
Published: January 2024

As one of the Penta Helix elements in crisis management, Muhammadiyah conducted humanitarian efforts throughout the pandemic, notably in East Kalimantan, through the Muhammadiyah COVID-19 Command Center (MCCC). As a collective humanitarian memory of East Kalimantan during the height of the COVID-19 pandemic, this study attempts to present an overview of all the volunteer activities conducted by MCCC in Balikpapan and Samarinda during the pandemic. Descriptive analysis and qualitative technique are utilized in this study. To gather primary data, two informants from Balikpapan and four informants from Samarinda were interviewed. Secondary data came from reporting documents from the Muhammadiyah Disaster Management Center (MDMC) in East Kalimantan, which were located through a Google search for pertinent terms. The following are the study's findings: (1) In Balikpapan and Samarinda, MCCC volunteers took part in emergency response and disaster risk mitigation operations. (2) They give medical aid, apply disinfectants, and conduct out programs related to food security. (3) They go a long way to help others. They are all living examples of that since they have all survived COVID. During the peak of the COVID-19 pandemic, one individual was hospitalized, others were forced to self-isolate, and there were no reports in the media about any philanthropic activities. In conclusion, as volunteers are at high danger during the COVID-19 pandemic, their goodness cannot be questioned.
Bio-active principles in Commiphora africana resin dichloromethane extract and their insecticidal activity against bed bugs
Authors: Wairagu Norman W. , Wachira Benson M. , Githiomi Joseph K. , Oduor Nellie , Ng’ang'a Margaret M.
Published: January 2024

Bed bugs (Cimex lecturalius Linnaeus) are ecto-parasite pests that wholly feed on human and domestic animals’ blood and can cause anemia to the host on heavy feeding. Bed bug control has proved difficult due to various challenges including; development of insecticide resistance, high associated cost and environmental pollution. Natural herbal-based phytochemicals remain unexploited and we focused on Commiphora africana (A. Rich.) Engl. resin traditionally used in bed bug control in the coastal region of Kenya. We previously showed that dichloromethane extract of C. africana resin is highly repellent and toxic against bed bugs. In this study, we isolated compounds from the dichloromethane extract using column chromatographic techniques. The isolated compounds were evaluated for repellency and toxicity against bed bugs; and identified using Gas chromatography linked to mass spectrometer (GC-MS), Fourier Transform Infra-red (FTIR), 13C- and 1H Nuclear Magnetic Resonance techniques. Five compounds: taraxasterol, pseudo-taraxasterol, beta-sitosterol, fungisterol and guggusterol were isolated and characterized for the first time in this plant. Fungisterol had the highest repellency (75%) against bed bugs which was not significantly different (P>.05) to the positive control (neocidol) (74%) after > one-hour exposure. Fungisterol also elicited highest toxicity against bed bugs with LC50 of 25.73 mg/L after 24 h exposure. Blending fungisterol with other identified active terpenes did not synergize the overall repellent/toxic responses. This study identifies active compounds in C. africana resin and therefore lays a solid background in bed bug control using isolated compounds.
Research on the management scheme of urban flooding based on GIS technology
Authors: Meili Chen , Samat Narimah , Tilaki Mohammad Javad Maghsoodi
Published: January 2024

With rapid urbanization, flooding disasters caused by heavy rainfall and floods have brought huge economic and social losses. Therefore, it is critical to seek a scientific and effective stormwater management solution. Using GIS technology, this study focuses on the growing urban flooding problem in three stages: before, during, and after the rainstorm. In the pre-storm stage, GIS is used for flood risk assessment and prediction management to provide accurate early warning information and decision support so that timely countermeasures can be taken. In the mid-storm stage, GIS plays a key role in command and dispatch and emergency response, enabling task assignment and dispatch optimization, and facilitating inter-departmental collaboration. In the post-storm phase, GIS technology is used to identify flooding problem areas, evaluate management effectiveness, and offer support for summarizing lessons learned and improving the urban flooding management system. Hence, this study provides scientific and efficient flood management solutions to reduce flood risks, improve city resilience to floods, and promote urban sustainable development. Through the application of GIS technology, the proposed findings will reveal that spatial analysis, data management, and decision support functions can be employed to provide comprehensive and systematic solutions for urban flood management.
Man versus machine: cost and carbon emission savings of 4G-connected Artificial Intelligence technology for classifying species in camera trap images
Authors: Smith James , Wycherley Ashleigh , Mulvaney Josh , Lennane Nathan , Reynolds Emily , Monks Cheryl-Ann , Evans Tom , Mooney Trish , Fancourt Bronwyn
Published: January 2024

Timely and accurate detection and identification of species are crucial for monitoring wildlife for conservation and management. Technological advances, including connectivity of camera traps to mobile phone networks and artificial intelligence (AI) algorithms for automated species identification, can potentially improve the timeliness and accuracy of species detection and identification. Adoption of this new technology, however, is often seen as cost-prohibitive as it has been difficult to calculate the cost savings or qualitative benefits over the life of the program. We developed a decision tool to quantify potential cost savings associated with incorporating the use of mobile phone network connectivity and AI technologies into monitoring programs. Using a feral cat eradication program as a case study, we used our decision tool to quantify technology-related savings in costs and carbon emissions, and compared the accuracy of AI species identification to that of experienced human observers. Over the life of the program, AI technology yielded cost savings of $0.27m and when coupled with mobile phone network connectivity, AI saved $2.15m and 115,838kg in carbon emissions, with AI algorithms outperforming human observers in both speed and accuracy. Our case study demonstrates how advanced technologies can improve accuracy and cost-effectiveness and improve monitoring program efficiencies.
Did alcohol facilitate the evolution of complex societies?
Authors: Hrnčíř Václav , Chira Angela , Gray Russell
Published: January 2024

The size and complexity of human societies increased dramatically over the Holocene. Researchers have proposed a variety of potential drivers of this major transition1–4, including our predilection for alcoholic beverages5–7. This "drunk" hypothesis argues that drinking alcohol facilitated the rise of complex societies because it promotes social bonding and enhances human creativity5. However, systematic cross-cultural evidence for the claim is lacking. Here we test this hypothesis with a global sample of 186 largely non-industrial societies8. We find a positive (albeit modest) relationship between the presence of indigenous alcoholic beverages and the level of political complexity, even after controlling for several potential confounders, including common ancestry, spatial proximity, environmental productivity and agricultural intensity. Furthermore, we find that the largest effect of alcohol on political complexity is in less integrated societies, such as “acephalous” societies and “simple chiefdoms”. Our results support the idea that group-level social benefits of alcohol tended to outweigh its disruptive effects, at least in the case of traditional low-alcohol beverages, and thus positively contributed to the evolution of human societies.
Land surface temperature variations in a low-latitude high-altitude mountainous area of southwest China
Authors: Huo Hong , Sun Changping
Published: January 2024

High-altitude areas are thought to be more sensitive and responsive to climate change, but long-term series of land surface temperature (LST) observations are still inadequate in low-latitude high-altitude mountainous areas. In this paper we comprehensively investigate the spatiotemporal variations in the LST and its dominant driving factors at both annual and seasonal scales from 2001 to 2020 based on the long-term series of MODIS data over the Yunnan Plateau (YNP) in southwest China, with a special focus on elevation-dependent warming (EDW). The results indicated that the annual LST showed a general increasing trend over the past 20 years, with an average rate of 0.18°C decade− 1, being stronger during summer season (0.47°C decade− 1). Moreover, an obvious asymmetric diurnal warming was observed; the nighttime warming rate was 0.43°C decade− 1, which is much faster than the daytime cooling rate (− 0.08°C decade− 1). We also confirmed the presence of EDW; it behaved more strongly at high elevations (above 3500 m) at a rate of 0.41 ºC decade− 1. Spatially, a warming trend was found in most areas, especially in high-cold mountains, hot-dry river valleys, and the tropics. In contrast, in the northeastern YNP and western side of the Ailao Mountains a cooling trend was observed. In most areas, air temperature is the dominant climatic factor influencing changes in LST at an annual, autumn and winter timescales, while precipitation plays a major role in annual LST changes in the northwest and northeast. LST and warming trend largely differenced with respect to land cover types, with the highest values occurring in built-up lands. This research is expected to contribute to a better understanding of surface-atmosphere interaction and climate change processes in YNP.
Microbial iron limitation in the ocean’s twilight zone
Authors: Repeta Daniel , Li Jingxuan , Babcock-Adams Lydia , Boiteau Rene , McIlivin Matthew , Manck Lauren , Sieber Matthias , Lanning Nathan , Bundy Randelle , Bian Xiaopeng , Streanga Iulia-Madalina , Granzow Benjamin , Church Matthew , Fitzsimmons Jessica , John Seth , Conway Tim
Published: January 2024

One of the major advances in ocean biogeochemistry achieved over the past three decades is an understanding of how nutrients, primarily nitrate, phosphate and iron (Fe), combine in complex patterns to limit and shape primary production in the surface ocean1-3. Below the surface ocean, remineralization of sinking organic matter rapidly regenerates nutrients, and microbial metabolism in the upper mesopelagic “twilight zone” (200-500 m) instead appears to be limited by the delivery of labile organic carbon4,5. In contrast to the large number of studies describing nutrient limitation in ocean surface waters, nutrient limitation of microbial production in the mesopelagic has been unexplored. Here we report the distribution and uptake of siderophores, biomarkers for microbial Fe limitation6, across a meridional section of the eastern Pacific Ocean. Siderophore concentrations were high in chronically Fe limited surface waters, but they were also surprisingly high in the twilight zone underlying the North and South Pacific subtropical gyres, two key ecosystems for the global carbon cycle. Bacterial Fe deficiency due to low Fe availability is likely characteristic of the twilight zone in several large ocean basins, greatly expanding the region of the marine water column where nutrients limit microbial metabolism with potentially significant impacts on ocean carbon storage.
Acquired resistance to CDK4/6 inhibition is associated with dysregulation of multiple pathways including cyclin D-CDK4/6-RB, EGFR/HER, AKT/mTOR and IFN signaling
Authors: Spears Melanie , Bathurst Lauren , Liao Linda , Hopkins Megan , Crozier Cheryl , Trinh Quang , III Emanuel Petricoin , Bayani Jane , Bartlett John
Published: January 2024

While the use of CDK4/6 inhibitors has significantly improved outcomes for patients with ER+/HER2- tumours, understanding the mechanisms responsible for resistance is essential to identify predictive biomarkers and alternative treatment options after tumour progression. To this end, we developed in-vitro models of acquired resistance to palbociclib and abemaciclib using MCF7 and T47D cell lines. Genomic, transcriptomic, and proteomic analyses were used to identify potential actionable molecular alterations in these models. Results show that acquired resistance was associated with dysregulation of multiple signaling pathways, including cyclin D-CDK4/6-RB, EGFR/HER and AKT/mTORC1. Strikingly, acquired resistance across all cell lines was also associated with an upregulated interferon (IFN) response. Expression of an IFN-based gene signature derived from these models was upregulated in breast cancer cell lines and early-stage tumours intrinsically resistant to CDK4/6i, and thus warrants further clinical evaluation as a predictive biomarker of resistance.
Metabolomic spectral biomarker selection towards early diagnostic of Fusarium oxysporum in tomato
Authors: García-Barrera Laura J. , Meza-Zamora Stefani A. , Noa-Carrazana Juan C. , Macuil Raul Jacobo Delgado
Published: January 2024

The interaction of phytopathogenic organisms and plants generates physiological and biochemical changes in the latter, however the effects in the plants are rarely visible in the first stages of infection. Novel optical techniques can help to improve the early detection of the phytopathogenic organisms in tomato plants without the plant sacrifice. In this work infrared spectroscopy and chemometric methods were used in an intent to determinate the effects of Fusarium oxysporum in tomato leaves cultivated in pots. Fusarium oxysporum was molecular identified and its pathogenicity was test in vitro. Three treatments were evaluated, control, water stress, and fungal inoculated plants (1x108 conidia/ml); for 55 days post infection in pots in greenhouse under semi controlled conditions. Phenotypical results were followed twice a week for 8 weeks, the phenotypical characteristics were very similar in almost all sampling times except in height specially in the first 27 days post infection, after this time the height was similar in the three treatments. The stalk and root dried matter analysis does not show statistical differences; however, the infrared results, develop in the adaxial surface of leaves, shows differences in peaks associated to salicylic acid, jasmonic acid, abscisic acid, and proline in the first 27 days post infection. The PCA-LDA development in the time groups, help to have a good classification in the first 27 days as first group, and in the rest of the sampling times as second group.
Understanding the drivers of continued mpox transmission in the United States: a modeling study
Authors: Kipshidze Nodar , Klein Eili , Yang Wan
Published: January 2024

The 2022 mpox epidemic in the United States (U.S.) peaked in the summer of 2022, but over a year later, new cases continue to emerge. To understand why mpox continues to spread, albeit at low levels, we explored three mechanisms: (1) underdetection of cases, (2) waning immune protection from vaccination, and (3) waning immune protection from prior infection. We refined a multilayer epidemic network model to simulate these mechanisms and fit this model to the 2022 mpox outbreaks in Chicago, New York City, and San Francisco. Analyses across mechanisms suggest that underdetection was the most likely driver of prolonged transmission. Furthermore, the duration of simulated outbreaks was most sensitive to changes in the proportion of undetected cases. Our findings underscore the need for enhanced surveillance to capture the true scope of mpox transmission in the U.S., reduce the possibility of future resurgence, and enable effective outreach to key affected populations.
Association of hereditary hemochromatosis with portal vein thrombosis: A national inpatient sample (2016-2020) analysis
Authors: Kharel Himal , Pokhrel Nishan Babu , Kharel Zeni , Bhandari Samikchhya Keshary , Niu Chengu , Jain Tripti , Sanjeevi Aditya
Published: January 2024

Hereditary hemochromatosis is a common inherited metabolic disorder of iron metabolism with variable penetrance. Portal vein thrombosis has several well-known causes including cirrhosis, myeloproliferative neoplasm, inflammatory conditions of abdomen (acute appendicitis, acute diverticulitis, and acute pancreatitis), intra-abdominal malignancy, intra-abdominal surgery, and thrombophilia. It is unknown whether hereditary hemochromatosis is associated with portal vein thrombosis. A retrospective analysis of the NIS database from 2016 to 2020 was conducted using International Classification of Diseases (ICD-10) codes to identify hospitalizations with portal vein thrombosis. We used Fischer's exact test to compare proportions and the student's t-test to compare continuous variables. We used multivariate regression analysis to calculate the adjusted odds ratio after controlling for age, gender, primary payer, Charlson Comorbidity index, cirrhosis, myeloproliferative neoplasm, inflammatory conditions of abdomen (acute appendicitis, acute diverticulitis, and acute pancreatitis), intra-abdominal malignancy, intra-abdominal surgery, history of past thrombosis, thrombophilia, end stage renal disease, obesity, smoking, and hyperlipidemia.There were 25805 hospitalizations with primary diagnosis of portal vein thrombosis. Multivariate logistic regression showed that hereditary hemochromatosis was independently associated with portal vein thrombosis (OR = 4.7, 95% CI = 1.15 to 19.35, p-value = 0.03) along with cirrhosis, myeloproliferative neoplasm, inflammatory conditions of abdomen, intra-abdominal malignancy, history of thrombosis, history of abdominal surgery, history of thrombophilia, and end stage renal disease among other factors.
Problems of operation of positive pressure ventilators on the basis of surveys of Polish officers of the State Fire Service
Authors: Kaczmarzyk Piotr , Warguła Łukasz , Janik Paweł , Krawiec Piotr , Bąk Damian , Klapsa Wojciech
Published: January 2024

Positive pressure ventilators used by 97.7% of officers of the National Fire Service in Poland, are characterized by work that is not in line with the expectations of the firefighters. In order to improve the technical and operational features of these devices, a survey was conducted among 25,000 eligible firefighters, identifying the application of these devices, problems in use and expected development directions. A total of 682 officers voluntarily completed the survey. Based on their findings, it was determined that ventilators are most often used to smoke out buildings after or during a fire. Mentioned problems when using these devices were mainly noise (78.2%), exhaust emissions (68.5%), and impediments to mobility through the device’s relatively heavy weight (40.2%). Other inconveniences were mentioned by less than 20% of firefighters. Polish firefighters expect the development of these devices mainly in terms of the above-mentioned features (noise reduction (81.7%) and reduction of the weight and size of the ventilators (about 50%)). Other expectations relate to the improvement of smoke removal in buildings: increasing the efficiency of smoke removal (46.4%) and efficiency regarding the rate of smoke removal in a building by increasing the size of the incoming airflow from the building’s surroundings (33.2%). About 15% of firefighters expect changes in the operation of the ventilator itself, that is, an increase in the effective operating time (electric ventilators) and an increase in the device’s uptime. The article also presents suggestions for device development based on the available state of the art.
High-resolution kinetics and cellular determinants of antibody response to SARS-CoV-2 over two years after COVID-19 vaccination
Authors: Dobaño Carlota , Rubio Rocío , Macià Dídac , Barrios Diana , Vidal Marta , Jimenez Alfons , Molinos-Albert Luis , Diaz Natalia , Canyelles Mar , Lara-Escandell Maria , Planchais Cyril , Santamaria Pere , Carolis Carlo , Izquierdo Luis , Aguilar Ruth , Moncunill Gemma
Published: January 2024

Despite widespread COVID-19 vaccine coverage, breakthrough infections are increasing, mainly driven by waning immunity and the emergence of SARS-CoV-2 Omicron variants. Here, we characterized the IgM, IgA and IgG kinetics in 55 visits over two years post-COVID-19 vaccination, and T-cell responses six months post-booster, in 31 healthy adults. Antibodies to Wuhan SARS-CoV-2 antigens and Alpha, Delta and Omicron variants were quantified by Luminex. SARS-CoV-2-specific T-cell responses were measured by activation-induced marker (AIM) and IFN-γ/IL-2 FluoroSpot assays. Antibody trajectories varied among isotypes. IgG decayed slowly during the first months and subsequently slowed down. IgA exhibited a rapid initial decay rate that decelerated stabilizing above the seropositivity threshold. Contrarily, IgM rapidly dropped to undetectable levels after primary vaccination. Importantly, three vaccine doses induced higher and more persistent anti-spike (S) IgG and IgA compared to two doses, whereas infection led to superior and longer-lasting IgG and IgA anti-S compared to three or two vaccine doses. Antibody levels to Omicron subvariants had shorter persistence than to ancestral virus. Finally, polyfunctional T cells correlated positively with subsequent IgA responses. These results revealed distinct isotype kinetics with non-constant decay rate and highlighted the benefits of booster doses in enhancing and sustaining antibody responses
WNT3 promotes chemoresistance to 5-Fluorouracil in oral squamous cell carcinoma via activating the canonical β-catenin pathway
Authors: Sun Kairui , Zhang Xuyang , Gan Ruihuan , Yan Yuxiang , Zhang Chaochao , Zheng Dali , Lu Youguang
Published: January 2024

Objectives
5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of drug resistance has significantly limited its clinical application. Therefore, there is an urgent need to determine the mechanisms underlying drug resistance and identify effective targets. In recent years, the WNT signaling pathway has been increasingly studied in cancer drug resistance; however, the role of WNT3, a ligand of the canonical WNT signaling pathway, in OSCC drug resistance is not clear. This study delved into this potential connection.
Materials and Methods
5FU-resistant cell lines were established by gradually elevating the drug concentration in the culture medium. Differential gene expressions between parental and resistant cells underwent RNA sequencing analysis, which was then substantiated via Real-time quantitative PCR (RT-qPCR) and western blot tests. The influence of the WNT signaling on OSCC chemoresistance was ascertained through WNT3 knockdown or overexpression. The WNT inhibitor methyl 3-benzoate (MSAB) was probed for its capacity to boost 5FU efficacy.
Results
In this study, by constructing 5FU-resistant OSCC cell lines, the WNT/β-catenin signaling pathway was obviously activated in the drug-resistant cell lines through transcriptome sequencing analysis, RT-qPCR and western blot verification, and the key ligand for activation of the pathway, WNT3, was found. By knocking down WNT3 in resistant cells or overexpressing WNT3 in parental cells, we found that WNT3 promoted 5FU-resistance in OSCC. In addition, the WNT inhibitor MSAB reversed 5FU-resistance in OSCC cells.
Conclusions
These data underscored the activation of the WNT/β-catenin signaling pathway in resistant cells and identified the promoting effect of WNT3 upregulation on 5FU-resistance in oral squamous carcinoma. This may provide a new therapeutic strategy for reversing 5FU-resistance in OSCC cells.
Clinical Relevance
The clinical relevance of this study lies in providing a new therapeutic strategy for reversing 5FU-resistance in OSCC.
Glue embolization under inflow and outflow control by balloon occlusion for renal arteriovenous malformation treatment
Authors: Suzuki Tensei , Yamaguchi Hidenori , Kojima Mitsuaki , Kariyasu Toshiya , Nakamoto Raira , Nishikawa Makiko , Machida Haruhiko , Shoko Tomohisa
Published: January 2024

Background
Glue embolization under inflow and outflow control via balloon occlusion may allow successful embolization.
Case report
A 45-year-old woman presented with gross hematuria. Right renal arteriovenous malformation on abdominal contrast-enhanced computed tomography necessitated urgent transcatheter arterial embolization. Right renal digital subtraction angiography revealed a single tortuous and dilated vessel converging to an aneurysmal dilated vein. To selectively embolize the malformation, we closed the arterial side with a microballoon and attempted glue embolization; filling occurred unexpectedly early, and another balloon on the vein side helped control the renal vein blood flow. Glue embolization was performed without adverse events.
Conclusions
Glue embolization for high-flow arteriovenous malformation under balloon occlusion-mediated inflow and outflow control can effectively and safely embolize complete target vessels.
A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in telomere length
Authors: Wang jia , Li Wen-wei , Qiu Zhi-kun
Published: January 2024

Background: There is ongoing controversy over the potential for telomere shortening caused by alcohol consumption and smoking. Therefore, the purpose of this study is to investigate the possibility of a relationship between telomere length and alcohol consumption or smoking.
Methods: To evaluate the causal relationship of smoking and alcohol consumption on telomere length, we conducted a bidirectional 2-sample Mendelian randomization (MR) analysis. Genetic associations of telomere length (n = 472,174) and lifetime smoking (n = 462,690) were obtained from UK Biobank datasets, and genetic associations of smoking initiation (n = 1,232,091), smoking cessation (n = 547,219), cigarettes per day (n = 337,334), and drinks per week (n = 941,280) were obtained from genome-wide association studies (GWAS) research. We used the inverse-variance weighted (IVW), weighted median, weighted mode, MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO), and MR Egger regression methods to evaluate the association of genetically predicted exposure with the risk of outcome.
Results: MR demonstrated the higher risk of shorter telomere length was significantly associated with smoking initiation (β = -0.063, 95% confidence interview (CI): -0.082, -0.045, p < 0.05), smoking cessation (β = -0.1, 95%CI: -0.168, -0.032, p = 0.003), cigarettes per day (β = -0.05, 95%CI: -0.093, -0.007, p = 0.021), lifetime smoking (β = -0.182, 95%CI: -0.244, -0.121, p < 0.05), and drinks per week (β = -0.079, 95%CI: -0.143, -0.014, p = 0.016). But the reversal causality was not found.
Conclusion: Our results provide evidence of potential causal association of smoking and alcohol consumption on telomere length. It may contribute to the prevention of premature shortening of telomere length.
The Effects of Emotion Regulation and Students’ Perceived Challenges on Emotion Synchrony in Collaborative learning
Authors: Huang Xiaoshan , Li Shan , Wang Tingting , Lajoie Susanne P.
Published: January 2024

In this study, we explored the relationships among students’ perceived challenges in collaborative learning, emotion regulation strategies (i.e., reappraisal and suppression), and emotion synchrony (i.e., valence synchrony and arousal synchrony) in natural classroom settings. We performed the partial least squares structural equation modeling (PLS-SEM) method for data analysis. The results revealed a positive and direct effect of cognitive reappraisal on arousal synchrony, and a negative and direct effect of cognitive reappraisal on valence synchrony. Moreover, students’ perceived challenges in collaborative learning had a negative effect on their arousal synchrony. Students’ perceived challenges also played a mediating role in the relationship between cognitive reappraisal and arousal synchrony. As a total effect, cognitive reappraisal still positively and significantly predicted arousal synchrony. This study provided insights into students’ emotional responses in collaborative learning and informed the design of collaborative learning environments. This study has also methodological implications regarding the analysis of emotion synchrony.
Evaluating the Underreporting of Diseases in the Philippines During the COVID-19 Pandemic through Comparative Forecast Analysis
Authors: Parreño Samuel John
Published: January 2024

Background
The COVID-19 pandemic has significantly impacted global health systems, particularly in the Philippines. The redirection of healthcare resources towards COVID-19 has raised concerns about the potential underreporting and surveillance of other communicable diseases. This study explores whether the pandemic has led to the underreporting of these diseases.
Methods
The study employs Predictive Mean Matching (PMM) for data completeness and uses Seasonal Autoregressive Integrated Moving Average (SARIMA), Neural Network Autoregressive (NNAR), and Holt-Winters (HW) models for disease forecasting. The actual reported cases of diseases for the years 2020 and 2021 are compared with the forecasts to identify discrepancies.
Results
Significant underreporting was observed for most diseases studied, with notable exceptions such as AFP. NNAR models outperformed SARIMA and HW in forecasting accuracy. Diseases like Measles, Diphtheria, and Rubella showed substantial underreporting, while vector-borne diseases like Dengue and Chikungunya, and waterborne diseases such as Typhoid Fever and Cholera, also indicated underreporting.
Conclusions
The study reveals significant underreporting of various diseases in the Philippines during the COVID-19 pandemic. The effective use of advanced predictive models underscores the potential of these tools in enhancing disease surveillance and highlights the need for robust health systems capable of sustaining surveillance during crises.
Preparation of NiFeCoMnCr Hydroxide on Nickel Foam by Corrosion Method and its Enhanced Electrochemical Performance in Oxygen Evolution Reaction
Authors: Lee Hyein , Minho Han , Heejin Noh , Yu Taekyung
Published: January 2024

The corrosion method offers a viable means to fabricate efficient electrocatalysts for electrochemical reactions, ensuring strong adhesion between the substrate and the formed material and minimizing resistance between the catalyst and the electrode. This study introduces a method for synthesizing a high-performance oxygen evolution reaction (OER) catalyst by cultivating a transition metal-based multimetallic hydroxide on Ni foam via corrosion. The hydroxide, comprising Ni, Fe, Co, Mn, and Cr, uniformly coated the Ni foam, ensuring even distribution of each transition metal within the catalyst. The resultant NiFeCoMnCr hydroxide catalyst demonstrated enhanced OER performance, evidenced by reduced overpotential and improved stability, outperforming binary, ternary, and quaternary hydroxides.