bluuebunny/crossref_metadata_2025 huggingface dataset:
One-pot highly diastereoselective synthesis of some novel spiro pyrrolizidines via 1,3-dipolar cycloaddition reaction of azomethine ylide
Authors: Azizian Javad , Karimi Ali Reza , Dastkhan R. , Mohammadi Ali A. , Mohammadizadeh Mohammad R.
Published: December 2009

Indenoquinoxaline-11-one derivatives react with proline and N-aryl maleimides via decarboxylative azomethine ylide formation and subsequent 1,3-dipolar cycloaddition involving an exo- transition state to give new heterocyclic adducts in 71–94% yields.
A Facile Cleavage of the Carbon-Nitrogen Bond of Aromatic Imines Using Acylation Reagents in the Presence of Catalytic Amounts of Ytterbium Triflate
Authors: Su Weike , Jin Can
Published: December 2009

Catalytic amounts of ytterbium triflate were used to promote the cleavage of aromatic imines with acylation reagents, including acyl chlorides and anhydrides or sulfonyl chlorides, to obtain aldehydes and acyl amides or sulfonamides in high yields. Products of Friedel–Crafts acylation have not been detected.
Synthesis and X-ray Crystal Structure of 3-oxo-23, 24-Dinorchol-4-Ene-22-Cyanohydrin
Authors: Cox Philip J. , Nahar Lutfun , Sarker Satyajit D. , Turner Alan B.
Published: December 2009

(22R) and (22S) 3-Oxo-23,24-dinorchol-4-ene-22-cyanohydrin have been synthesised from 3-oxo-23,24-dinorchol-4-ene-22-al and the crystal structure of the (22R) epimer has been determined by X-ray crystallography.
Reactivity of [1]Benzopyrano[4,3-c][1,5]Benzodiazepin-7(8H)-Ones Towards Some N-Binucleophiles
Authors: Trimeche Belsem , Gharbi Rafik , Houla Souhir El , Martin Marie-Thérèse , Nuzillard J. M. , Mighri Zine
Published: December 2009

The behaviour of [1]benzopyrano[4,3- c][1,5]benzodiazepin-7(8 H)-ones 1a–c towards some N-binucleophiles have been studied. With non-aromatic hydrazines the reaction carried out in acidic medium led exclusively to the unexpected [1]benzopyrano[4,3- c]pyrazol-4-ones 4 and 5. Compounds 1 reacted under less drastic conditions with variously substituted amidines and guanidines to give 5 H-[1]benzopyrano[4,3- d]pyrimidin-5-ones (10a–d). A general mechanism is proposed to explain the formation of the obtained heterocycles.
Stereoselective Synthesis of (E)-α-Silylvinyl Tellurides via the Hydrozirconation Reaction of Alkynylsilanes
Authors: Cai Mingzhong , Huang Jiadi
Published: December 2009

( E)-α-silylvinyl tellurides have been synthesised stereoselectively via the hydrozirconation of alkynylsilanes, followed by reaction with aryltellurenyl iodides. ( E)-α-Silylvinyl tellurides can undergo cross coupling reaction with Grignard reagents in the presence of [NiCl2(PPh3)2] catalyst to give ( Z)-1,2-disubstituted vinylsilanes in good yields.
Synthesis of (4S*,5S*)-Diphenyl-1,3,4,5-Tetrahydro-2H-[1]Benzopyrano [4,3-d]Pyrimidine-2-Thiones by Base-Catalysed Cyclocondensation of (E)-3-Benzylideneflavanones with Thiourea, and Determination of Their Monoacetylation Site
Authors: Mallik Asok K. , Chattopadhyay Falguni , Dey Dilip Kumar , Patra Amarendra , Elmali Ayhan
Published: December 2009

Base-catalysed cyclocondensation of ( E)-3-benzylideneflavanones with thiourea has been found to be highly stereoselective, producing (4 S*,5 S*)-diphenyl-1,3,4,5-tetrahydro-2 H-[1]benzopyrano[4,3- d]pyrimidine-2-thiones in high yield, the structure of one of which has been determined by X-ray crystallography. Just like 4,6-diaryl-3, 4-dihydropyrimidine-2(1 H)-thiones, the said products also undergo monoacetylation on treatment with Ac2O. The site of acetylation in both of these classes of compound are established by detailed NMR spectral studies.
A Study on the Heterogeneous Reaction of Trialkylsilyl Chlorides with Inorganic Salts and Monocarboxylates Catalysed by PEG400
Authors: Du Yun-Fei , Cao Yu-Qing , Dai Zhi , Chen Bao-Hua
Published: December 2009

The important and useful trialkylsilyl pseudohalides R3SiX, where X=NCS, NCO, N3 or CN and R=methyl or ethyl, and trimethylsilyl monocarboxylates, where X=RCOO, were readily prepared in high yields by nucleophilic substitution of R3SiCl with X ions provided by NaX or KX at room temperature catalysed by PEG400 and zinc iodide. The reactions of trimethylsilyl chloride with some metal oxysalts were also studied for the first time.
The Sulfonation of Methyl and Prenyl Ethers of Naturally Occurring Phenols with Trimethylsilylchlorosulfonate as Sulfonating Agent
Authors: Petit Philippe , Bourgeois Paul
Published: December 2009

At room temperature trimethylsilylchlorosulfonate has been found to be an effective and a mild reagent for the nuclear sulfonation of some methyl and prenyl ethers of naturally occurring phenols.
Synthesis and Spectral Characterisation of Lanthanide(III) Complexes of Trimethoprim
Authors: Karthikeyan G. , Raj K. Mohan , Elango K.P. , Kumar K. Girish
Published: December 2009

A new series of hepta coordinated lanthanide(III) complexes of the type [ML2Cl3] (where M = LaIII, PrIII, NdIII, SmIII, GdIII, TbIII, DyIII or YIII, L = trimethoprim) have been synthesised. The new complexes were characterised using various physico-chemical methods such as elemental analysis, spectral (IR, UV–VIS, 1H NMR), magnetic and X-ray diffraction analysis. A monocapped trigonal prism structure has been tentatively proposed for the complexes.
Phosphotungstic Acid Catalysed One-Pot Synthesis of 5-Alkoxycarbonyl-4-Aryl-3,4-Dihydropyrimidin-2-Ones
Authors: Jin Tong-Shou , Xiao Jin-Chong , Chen Yan-Xue , Li Tong-Shuang
Published: December 2009

5-Alkoxycarbonyl-4-aryl-3,4-dihydropyrimidin-2-ones are synthesised by the one-pot reactions of aldehydes, β-ketoesters and urea using a catalytic amount of phosphotungstic acid (PTA) in ethanol. The modified Biginelli cyclocondensation not only shortens the reaction period and simplifies the operation, but also improves the yields.
A Facile Synthesis of 4,5-Dihydropyrazolo[4,3-c]Quinolines with Vilsmeier Reagent
Authors: Kumar K. Hemanth , Selvi S. , Perumal P.T.
Published: December 2009

4,5-Dihydropyrazolo[4,3- c]quinolines have been synthesised in moderate to good yields from dihydroquinolin-4-ones using the Vilsmeier reagent, under conventional and microwave irradiation conditions.
Samarium diiodide promoted one-pot syntheses of amides from azides and esters
Authors: Wang Xiaoxia
Published: December 2009

A one-pot synthesis of amides from azides and esters was realized in a SmI2-THF system under mild conditions and various amides were prepared in this way with good to excellent yields.
Thionation of carbonyl compounds using phosphorus pentasulfide and hexamethyldisiloxane under microwave irradiations
Authors: Polshettiwar Vivek , Nivsarkar Manisha , Paradashani Deepak , Kaushik M.P.
Published: December 2009

A novel and convenient microwave assisted thionation of carbonyl compounds using phosphorus pentasulfide and hexamethyldisiloxane is described. Thionation by this method gave the desired product in higher yield and shorter reaction time as compared to conventional methods.
Synthesis of new highly sterically hindered organosilicon compounds via displacement reaction of TsiSiCl3
Authors: Asadi Mohammad G. , Mohammadzadeh Rana A.
Published: December 2009

The displacement reaction of TsiSiCl3 with nucleophiles does not take place, but in this work we did this reaction with some alcohols and phenols in the presence of base, to product silyl ethers of the type TsiSiCl2OR, TsiSiCl2OAr, (R= n-Pr, i-Bu, i-Am, PhCH2, and Ar = Ph, C6H4OMe- p, C6H4NH2- p, C6H4NO2- p, C6H4COOMe- o, C6H4NHCOOMe- p).
The metabolism of the sesquiterpenoid 12-nor-8α-presilphiperfolan-9β-ol by the fungus Botrytis cinerea
Authors: Collado Isidro G. , Deligeorgopoulo Athina , Hanson James R. , Hitchcock Peter B. , Macias-Sánchez Antonio J.
Published: December 2009

12-Nor-8α-presilphiperfolan-9β-ol has been prepared from caryophyllene oxide as a mimic of botryane biosynthetic intermediates and its metabolism by Botrytis cinerea has been studied.
Efficient synthesis of 1,3,4-oxadiazolyl-1,8-naphthyridines under microwave irradiation
Authors: Mogilaiah K. , Reddy G. Randheer
Published: December 2009

An expeditious and convenient method for the synthesis of 1-(5-aryl-[1,3,4]oxadiazol-2-ylmethyl)-3-( m-chlorophenyl)-1 H-[1,8]-naphthyridin-2-ones 5 from [2-oxo-3-( m-chlorophenyl)-2 H-[1,8]naphthyridin-1yl]acetic acid arylidenehydrazides 4 using chloramine-T under microwave irradiation is described.
Characteristics of ring critical point as descriptors of H-bond strength
Authors: Palusiak Marcin , Grabowski Slawomir J.
Published: December 2009

The results of B3LYP/6-311+G* level of calculations show that the electron density and its Laplacian for the ring critical point (RCP) of the benzene ring as well as its position may be applied as useful parameters describing the H-bond strength for complexes of methoxybenzene with simple proton donors such as: HF, H2O, C2H2, NH2CH3, CH3F and C2H4.
A clean method for producing 4-aryl-7,7-dimethyl-5-oxo-3,4,5,6,7, 8-hexahydrocoumarin in aqueous media
Authors: Jin Tong-Shou , Wang Ai-Qing , Cheng Zhao-Li , Zhang Jian-She , Li Tong-Shuang
Published: December 2009

A synthesis of 4-aryl-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydrocoumarin from aromatic aldehyde, 5,5-dimethyl-1, 3-cyclohexadion and Meldrum's acid catalysed by hexadecyltrimethylammonium bromide in water is described. This method provides several advantages such as mild reaction conditions, simple work-up procedure and environment friendly.
Preparation and characterisation of new types of metallic- and heterodimetallic–butyltin glycolates
Authors: Sharma Nandu Bala , Singh Anirudh , Mehrotra Ram C.
Published: December 2009

Reactions of BuSn(OPri)3 with two equivalents of a number of glycols (HOGOH, where G = CMe2CMe2, CH(Me)CH(Me), CMe2CH2CHMe, and CMe2CH2CH2CMe2), with varying steric bites yield metallic glycolate complexes (1), (2), (3), and (4) with one residual hydroxy group; these on reacting with Al(OPri)3 and Nb(OPri)5 in a 1:1 molar ratio yield interesting heterodimetallic compounds of the general formulae BuSn(OGO)2Al(OPri)2 and BuSn(OGO)2Nb(OPri)4. All of these derivatives have been characterised by elemental analyses, spectroscopic (IR; NMR: 1H, 27Al, and 119Sn) studies and molecular weight determinations.
Synthesis of 4-alkoxy-N-substituted-1,8-naphthalimides
Authors: Triboni Eduardo R. , Berlinck Roberto G. S. , Politi Mario J. , Filho Pedro Berci
Published: December 2009

The present work deals with two improved methods for the synthesis of 4-alkoxy- N-alkyl-1,8-naphthalimides from 4-nitro- N-alkyl-1,8-naphthalimides employing in situ generation of the alkoxylating agent in the alcoholic saturated solution of alkaline metal carbonates.
Synthesis and reactions of 2-cyano-2-(5-oxo-3-phenyl-thiazolidin-2-ylidene)-acetamides
Authors: Metwally M.A. , Keshk E.M. , Fekry A. , Etman H.A.
Published: December 2009

The base promoted nucleophilic addition of cyanoacetamide derivatives 2a,b to equimolar amount of phenyl isothiocyanate in DMF containing potassium hydroxide afforded the corresponding potassium sulfide salts 3a,b which were not isolated but which underwent heterocyclisation upon treatment with chloroacetyl chloride to give the corresponding 2-cyano-2-(5-oxo-3-phenylthiazolidin-2-ylidene)-acetamide derivatives 4a,b. The reactions of 4a,b with aryl diazonium salts, bromine and aromatic aldehydes were studied in order to obtain compounds 5–11.
The hydroxylation of the enantiomeric hexahydro-10-methylnaphthal-4-en-3-ones† by Cephalosporium aphidicola
Authors: Parvez Aslam , Hanson James R.
Published: December 2009

The enantiomeric hexahydro-10-methylnaphthal-4-en-3-ones are hydroxylated by the fungus, Cephalosporium aphidicola at C-6 and at C-9 (steroid-like enantiomer) or at C-1 (steriod enantiomer).
A novel pyrenophane bearing tetraazathiapentalene skeleton
Authors: Hayashi Hirokazu , Matsumura Noboru , Mizuno Kazuhiko
Published: December 2009

A novel pyrenophane incorporating macrocyclic tetraazathiapentalene is synthesised and characterised. The absorption and fluorescence spectra in CH2Cl2 clearly showed π–π interaction between two pyrene rings including pyrene excimer emission.
Synthesis of cobalt(II) complexes with p-tert-butylcalix[4]arene-supported dihydroxamic acids
Authors: Li Jian-zhang , Zhang Chun-chun , Zhou Bo , Qin Sheng-ying
Published: December 2009

Four p-tert-butylcalix [4]arene supported dihydroxamic acids(H2L1–H2L4) and their cobalt(II) complexes CoL2 and CoL4 have been synthesised by condensation of hydroxylamine or N-substituted hydroxylamine with the calix [4] arene diacid chloride.
Self-assembly of 1,4-bis(pyrrol-2-ylmethyleneamine)butane mediated by Ni(II) and weak intermolecular interactions
Authors: Yang Lanying , Shan Xufeng , Chen Qingqi , Ma Jin Shi
Published: December 2009

A complex [NiL] was prepared by the self-assembly of 1,4-bis(pyrrol-2-ylmethyleneamine)butane (H2L) with Ni(OAc)2·2H2O, its structure was elucidated by X-ray analysis and the weak intermolecular interactions play a crucial role in the molecular packing.
An X-ray crystallographic study of the conformation of arylmethanesulfonamides
Authors: Hanson James R. , Hitchcock Peter B.
Published: December 2009

The conformations of eight arylmethanesulfonamides have been studied by X-ray crystallography. The average N–S bond length is significantly shorter than the sum of the covalent radii and the plane C(1)–N–S is rotated with respect to the aromatic ring.
Crystal structure of 4-benzyloxy- and 4-hydroxy– (Z)-3-[(6-bromo-1, 3-benzodioxol-5-yl)methylene]-2-(4-methoxybenzyl)-2,3-dihydro-1H-isoindol-1-ones
Authors: Moreau Anne , Couture Axel , Deniau Eric , Grandclaudon Pierre , Nowogrocki Guy
Published: December 2009

In contrast to unsubstituted models, the Horner reaction between phosphorylated 4-benzyloxyisoindolinone and ortho-bromobenzaldehyde gives rise selectively to the arylmethylene derivative with a Z-configuration.
Palladium-catalysed synthesis of 2-substituted indoles
Authors: Cho Chan Sik , Kim Jun Ho , Kim Tae-Jeong , Shim Sang Chul
Published: December 2009

2-Iodoaniline reacts with ketones in dioxane under reflux in the presence of a catalytic amount of Pd(dba)2/1, 1′-bis(di- iso-propylphosphino)ferrocene along with NaO tBu to afford 2-substituted indoles regioselectively in moderate to good yield.
A novel and efficient method for the synthesis of dibenzyl diselenides
Authors: Tian Fengshou , Lu Shiwei
Published: December 2009

A novel and efficient method for the synthesis of dibenzyl diselenides is described. Aromatic aldehydes were reduced via selenation with Se/CO/H2O in DMF under atmospheric pressure to give dibenzyl diselenides in high yields.
Syntheses of NLO diamino chromophores containing imidazole and thiophene rings as conjugation linkage
Authors: Wu Wei , Zhang Zhaoli , Zhang Xiaoyun
Published: December 2009

Three nonlinear optical chromophores bearing diamino groups have been synthesised, in which imidazole and thiophene rings were employed as elongated conjugation bridges.
A powerful aqueous solvent effect in an intramolecular Diels–Alder cyclisation
Authors: Kuhnert Nikolai , Sammes Peter G. , Smith Graham , Ward Robert W.
Published: December 2009

Significant promotion of both unactivated and activated carbocyclic Diels–Alder cyclisations across the furan ring system is observed on changing from an organic to an aqueous solvent system.
Highly selective Friede–Crafts monoacylation of ferrocene catalysed by ytterbium(III) triflate
Authors: Su Weike , Li Jianjun
Published: December 2009

In the presence of a catalytic amount of ytterbium(III) triflate[Yb(OTf)3], ferrocene reacted with anhydrides or acyl chlorides to afford monoacylferrocenes in high yields under moderate conditions. An efficient, simple and environmentlly friendly procedure was provided. The catalyst was easily recovered and reused without any loss of activity.
The inhibition of the fungus Botrytis cinerea by an eremophilane phytoalexin analogue
Authors: Collado Isidro G. , Deligeorgopoulou Athina , Hanson James R. , Hitchcock Peter B. , Macias-Sanchez J. Antonio
Published: December 2009

1α,11-Dihydroxy-4α,5α,7β,10β (H)-eremophilane 6 has been examined as a phytoalexin analogue and shown to be a powerful inhibitor of the growth of the plant pathogen, Botrytis cinerea. Its metabolites have been identified.
2, 6-Bis [3-N,N-Dimethylamino-1-Oxopropen-1-Yl]Pyridine as a Building Block in Heterocyclic Synthesis: Synthesis of 2,2′:6′,2″-Terpyridines and 2,6-Bis[Pyrazolyl, Isoxazolyl, Diazepinyl, Pyrazolo[5,1-a]Pyrimidinyl and Pyrazolo-[4,3-D]Pyridazinyl]Pyridines
Authors: Hassanien Abu Zeid Abd El Baset
Published: December 2009

A convenient synthesis is reported of some new 2, 2′:6′, 2″-terpyridines, and polycyclic pyridino-2,6-bis-[heterocycles and fused heterocycles] via reaction of 2,6-bis[3-N,N-dimethylamino-1-oxopropen-1-yl]pyridine (2) with various type of nucleophilic reagents. The biological screening showed that many of the prepared compounds have good antibacterial and antifungal activities comparable to Ampicillin and clotrimazoles.
Mesoporous carbon nanomaterial prepared directly by the second-side modified cyclodextrin through silica as template
Authors: Liu Yu , Guo Dong-Sheng , Zhang Heng-Yi , Zhao Yan-Li
Published: December 2009

A mesoporous carbon nanomaterial possessing high BET surface area ( ca 785 m2/g) and unique pore size (6–7 nm with narrow PSD) has been prepared directly by modified cyclodextrin-silica nanocasting, a simple, one-step preparative route to mesoporous carbon with the pore size controlled by a silica template.
Synthesis of hexabromo, hydroxy, epoxy, methoxy and nitroxy derivatives of tetralins and naphthalenes
Authors: Erenler Ramazan , Cakmak Osman
Published: December 2009

Stereoselective synthesises are described for naphthalene and tetralin derivatives. Hexabromo 2 and 3, monomethoxy 7, dimethoxy 6, dihydroxy 4 and dinitroxy 10 derivatives of tetralin have been obtained. Base-promoted elimination reactions of 6 and 4 provided monomethoxy 8 and 9 and diepoxy 5 naphthalenes respectively. The structures of these products were determined by 1H and 13C NMR spectra, mass spectra and micro analysis.
The stereochemistry of the Grignard reaction of some boat ring ketones in the diterpenoids
Authors: Uyanik Cavit , Hanson James R. , Hitchcock Peter B.
Published: December 2009

The stereochemistry of the addition of methylmagnesium bromide to boat ring B C-6 and C-7 ketones of the rosane and to C-16 of the beyerane diterpenoids has been shown to take place from the less-hindered face of the molecule.
The synthesis of tetrahedral clusters SOsCo2(CO)9, relevant to chiral tetrahedral clusters containing the SOsCoW core
Authors: Hu Bin , Zhu Bao-Hua , Zhang Wei-Qiang , Zhao Quan-Yi , Yin Yuan-Qi , Sun Jie
Published: December 2009

A simple route to synthesise clusters [SOsCo2(CO)9] in excellent yield and mild reaction conditions is described. Several new chiral tetrahedral clusters containing the Os element were synthesised by the thermal reaction of the precursor [(μ3-S)OsCo2(CO)9] with the functionally-substituted metal exchange reagents. The structure of cluster [(μ3-S)OsCoW(CO)8C5H4C(O)CH3] was established by X-ray single crystal diffraction.
The solid-phase oxidation of steroidal alkenes with potassium permanganate and metal salts
Authors: Salvador Jorge A.R. , Hanson James R.
Published: December 2009

The oxidation of steroidal alkenes by potassium permanganate and metal salts in the solid phase gives epoxides with a stereochemistry that can differ from that obtained by the use of per-acids.
Highly brominated biphenylenes as precursors for the convenient synthesis of 5,6,8,10-tetrabromobenzocyclooctene
Authors: Tutar Ahmet , Cakmak Osman , Karakas Mehmet , Onal Adem , Ide Semra
Published: December 2009

An efficient synthesis is described of hexabromides 5 and 6 by photobromination of biphenylene (1). Double dehydrobromination of hexabromides 5 and 6 with t-BuOK affords 5,6,8,10-tetrabromobenzocyclooctene (7) in nearly quantitative yield. The tetrabromide 7 is a valuable precursor for the preparation of functionalised substituted benzocyclooctenes (benzo[8]annulenes).
Recent Advances in the Study of Mechanochromic Transitions of Organic Compounds
Authors: Todres Zory V.
Published: December 2009

The article reviews a wide variety of mechanically induced colour changes in organic compounds. It considers structural and chemical transformations of the compounds that cause mechanochromism. When relevant, technical applications of the phenomenon are also highlighted.
Kinetics and Mechanism of Octacyanomolybdate(IV) Oxidation by Peroxynitrite
Authors: Mucientes A.E. , Rodríguez A. , Poblete F.J.
Published: December 2009

A kinetic study of the oxidation of octacyanomolybdate(IV) by peroxynitrite has been performed using a stopped-flow technique. The variation of kobs with the concentration of Mo(CN)48-, pH and temperature have been investigated. A reaction mechanism that involves homolysis of HOONO to form •OH and •NO2 radicals is proposed. Octacyanomolybdate(IV) is oxidised by HOONO (direct oxidation) and by the aforementioned radicals (indirect oxidation). The rate constants for HOONO homolysis ( k1) and direct oxidation ( k2) have been obtained along with the activation parameters of these steps.
Synthesis, Structure and Catalytic Behaviour in Oxidation of Cyclohexene of K4H2[SiW5Mo6M(H2O)O39]·xH2O (M=Mn2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+)
Authors: Hua Chun-Yan , Li Wei , Dai Li-Yi , Shan Yong-Kui
Published: December 2009

A series of the title complexes were synthesised. The general molecular formula K4H2[SiW5Mo6M(H2O)O39]· xH2O denoted as MW5 (M=Mn2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+) was determined by means of chemical analysis and thermoanalysis. IR-spectra, UV-spectra, XPS-spectra, and thermal decomposition were systematically investigated. The crystal structure of K4H2[SiW5Mo6Mn(H2O)O39]·22H2O was determined. The compounds were studied in oxidation of cyclohexene with 30% hydrogen peroxide as oxidant, which indicated that these transition-metal-substituted polyoxometalates were more effective than their corresponding parent compounds.
Synthesis and Crystal Structure of [Cu(dpq)2(ClO4)](ClO4)·1.5CHCl3 (dpq =2,3-di-2- Pyridylquinoxaline)
Authors: Liu He , Zhong Bo-Hua
Published: December 2009

The title complex [Cu(dpq)2(ClO4)](ClO4)·1.5CHCl3 (dpq =2,3-di-2- pyridylquinoxaline) was prepared by the ligand dpq with Cu(ClO4)2·6H2O and its structure was first elucidated by X-ray analysis.
[Nd(OTf)3] Mediated Facile Conversion of Ketoximes to Amides
Authors: Kanta De Surya
Published: December 2009

A variety of ketoximes, easily prepared from the corresponding ketones, undergo the Beckmann rearrangement upon treatment with [Nb(OTf)3] to afford the corresponding amides in excellent yields.
Reaction between Nitrogen–Containing Heterocycles and Dialkyl Acetylenedicarboxylate with Strong Ch-Acid: Synthesis of Stable Highly Functionalised 1,4-Diionic Nitrogen Betaines
Authors: Shaabani Ahmad , Bazgir Ayoob , Tavasoli-Rad Farahnaz , Bijanzadeh Hamid Reza , Razmara Freidoon
Published: December 2009

Protonation of highly reactive 1,4-zwitterionic intermediate generated in the reaction between pyridine or isoquinoline and dialkyl acetylenedicarboxylates by strong CH-acid such as 1,1,1,5,5,5-hexafluoropentane-2,4-dione, leads to a vinyl pyridinium cation derivatives, which undergo carbon centred Michael type addition with the conjugate base of the CH-acid to produce highly functionalised stable 1,4-diionic nitrogen betaines.
Regeneration of Carbonyl Compounds from Oximes by Chromium Trioxide Supported onto Hzsm-5 Zeolite under Microwave Irradiation in Solvent-Free Conditions
Authors: Heravi Majid M. , Hydarzadeh Fereshteh , Farhangi Yahya , Ghassemzadeh Mitra
Published: December 2009

A new method for the direct conversion of oximes into aldehydes and ketones by treatment with chromium trioxide supported onto HZSM-5 zeolite under microwave irradiation in solventless system is described.
An Efficient Method for the Preparation of β-Nitroalkanols in Room Temperature Ionic Liquids
Authors: Qian Weixing , Ju Fengyang , Bao Weiliang , Zhang Yongmin
Published: December 2009

β-Nitroalkanols were obtained in good to high yields from carbonyl substrates and nitroalkanes in the room temperature ionic liquids using DBU as catalyst under mild reaction conditions and short reaction times.
Synthesis of Bridged Fluorophenoxycyclotriphosphazene
Authors: Zhu Jiamei , Liu Weimin
Published: December 2009

The title compound has been synthesised by reaction of partially substituted hexachlocyclotriphosphazene with hydroquinone in moderate yield.
An Efficient Synthesis of 4-oxo-2-Thioxohexahydropyrimidines
Authors: Li Ji-Tai , Han Jun-Fen , Li Tong-Shuang
Published: December 2009

Several 4-oxo-2-thioxohexahydropyrimidines have been synthesised in very good yields from ethyl 2-cyanopropenoates and thiourea in sodium methoxide–methanol medium
Stereochemistry of New Nitrogen-Containing Heterocyclic Aldehydes. XII. Supramolecular Structures and Properties Models of Ruthenium with Quinoline Azodyes
Authors: Al-Shihri A.S. , Khalil M.M. , El-Sonbati A.Z.
Published: December 2009

Novel bis- and tris-complexes of ruthenium(III) with 5-(4′-derivative phenyldiazo)-8-hydroxy-7-quinolinecarboxaldehyde (HL n) have been characterised on the basis of elemental and thermal analysis, IR, magnetic and electronic spectral analysis as well as conductivity measurements. Electronic spectra show that all complexes are octahedral with chloride are attached to the metal ion in a 1:2 (metal:ligand) ratio. The spectral data were utilised to compute the ligand field parameters B, β and Dq. The B-values suggest a strong covalency in the metal-ligand σ-bond and the Dq-values indicate a medium-strong ligand field. It is apparent that the β values depend greatly upon the electronegativity of the donor atoms and the ligand structure and also the effect of the p-substituent groups. IR spectra indicate that the ligand is bidentate forming a six-membered chelating ring with concomitant formation of an intramolecular hydrogen bond. The ligands are present in associated form in solution via intermolecular hydrogen bonding. The effect of Hammett's constant on the ligand field parameters is also discussed.
Synthetic and Spectroscopic Investigations of Some Transition Metal Complexes of Hydroxy-Oxime Ligand
Authors: El-Tabl Abdou Saad
Published: December 2009

N,N-Diacetyloximo-1,3-diamino-2-hydroxypropane reacts with metal(II) acetate yields complexes. The complexes were characterised by elemental analyses, IR, UV-VIS spectra, molar conductances, magnetic moments, DTA, and ESR measurements. The ESR spectrum of a solid copper(II) complex [LCu] H2O, (6) at room temperature shows a broad signal, indicating spin exchange interactions take place between the copper(II) ions. However, in chloroform at 77K, the spectrum shows an axial type symmetry (dx2–y2) with considerable covalent bond character. The ESR spectra of a doped complex (7) in the temperature range 243–244 K have been investigated.
Synthesis of Pyridothienopyridines and Arylazothienopyridines
Authors: Moneam Maisa I. Abdel , El-Dean Adel M. Kamal
Published: December 2009

Treatment of aminothienopyridine 3 with arylidenemalononitrile affords pyridothienopyridine 4. Condensation of 3 with ethyl ethoxymethylene-cyanoacetate affords compound 5, which may be cyclised in diphenyl ether into pyridothienopyridine 6. Thiourea derivative 7 is cyclised using Br2/ AcOH, and ethyl chloroacetate to afford thiazolothienopyridine 8 and thiazolidinylthienopyridine 9 respectively. Compound 15 is condensed with aromatic aldehydes to give the corresponding arylidenethienopyridines 16a–d. The latter compounds undergo Michael addition with malononitrile to produce pyranothienopyridines 17a–d, Compound 15 was coupled with aromatic diazonium chloride to give the corresponding 2-arylazothienopyridine derivatives 20, but when treated with nitrous acids it dimerised to compound 19.
Triphenylphosphine Catalysed Stereoselective Synthesis of O-Vinylcyclopentenones
Authors: Baharfar Robabeh , Ostadzadeh Azita , Abbasi Atieh
Published: December 2009

The addition of 2-hydroxy-3-methylcyclopent-2-enone to propiolate esters is catalysed by triphenylphosphine to form O-vinylcyclopentenones in moderate yields.
Rapid and Convenient Synthesis of Acylhydrazines from Acyldiazenes
Authors: Li Jian-Ping , Yu Shu-Qiang , Qu Gui-Rong , Wang Yu-Lu
Published: December 2009

The synthesis of acylhydrazines by using phenylhydrazine as the reductant to hydrogenate acyldiazenes is reported.
A Convenient Preparation of Organyltellurophosphates Using a Polymer-Supported Hypervalent Iodine(III) reagent
Authors: Chen Jiang-Min , Lin Xiang-Jin , Huang Xian
Published: December 2009

Organyltellurophosphates can be synthesised smoothly in moderate to good yields by the free radical reaction of diorganyl phosphites with diorganyl ditellurides using poly[styrene(iodosodiacetate)] and sodium azide; the polymer reagent can be regenerated and recycled with no loss of reactivity.
Synthesis of Pyrazolotriazolopyrimidine Tri-Fused Heterocyclic Compounds
Authors: Liu Ying , Ren Jun , Jin Gui-Yu
Published: December 2009

This paper uses basic-catalysed method to convert 1 H-pyrazole-4-carboxamides into tri-fused heterocyclic systems containing two kinds of pyrazolotriazolopyrimidine framework. The synthesis of compounds 5–6 and reactions of them with some electrophiles have been investigated. Preliminary bioassay study showed that some compounds displayed high activity.
Synthesis of Spirostanic Analogues of Brassinosteroids via Homogeneous Permanganate Dihydroxylation
Authors: Rivera Daniel G. , Pando Orlando , Leliebre-Lara Vivian , Coll Deysma , León Fredy , Coll Francisco
Published: December 2009

Homogeneous non-aqueous permanganate dihydroxylation is used to synthesize spirostanic analogues of brassinosteroids bearing a variety of oxygen functions on ring B.
Synthesis and Characterisation of a High Valent Dinuclear Mn(III,III) Complex of a Triphenolate Ligand [N4O3]3- with two Extra Functional Groups
Authors: Li Hongyang , Shi Feng , Gao Yan , Zhang Rong , Peng Xiaojun , Sun Licheng
Published: December 2009

A new high valent complex [Mn2(III,III)L(μ-OAc)2]·PF67 was prepared, where L was the tri-anion of 2,6-Bis {[(2-hydroxy-5- tert-butylbenzyl)(pyridyl-2-methyl)amino]methyl}-4-methylphenol which contained two additional phenolate groups and two tert-butyl groups compared to its parent [Mn2(II,II)(bpmp)(μ-OAc)2]·PF6. These improvements narrowed the disparity between the new model and (Mn)4 cluster (OEC in nature).
Synthesis and Crystal Structure of (Z)-1-(Triphenylstannyl)-3-p-Chlorophenyl-1-Butene-3-ol
Authors: Li Xing-Qi , Zhu Dong-Sheng , Du Xi-Guang , Shao Kui-Zhan , Yang Xing-Hua
Published: December 2009

( Z)-1-(Triphenylstannyl)-3- p-chlorophenyl-1-butene-3-ol was synthesised and its structure was determined by X-ray diffraction analysis.
Trichlorolanthanoid(cat.)/Zinc System Promoted Cyclodimerisation of Arylidenemalononitriles and Arylmethylenecyanoacetates
Authors: Su Weike , Yang Bibo
Published: December 2009

A trichlorolanthanoid(cat.)/zinc system has been found to promote cyclodimerisation of arylidenemalononitriles and arylideneanoacetates to give highly functionalised cyclopentene derivatives in high yield and stereoselectivity.
Ammonium Chloride Mediated Reduction of Azo Compounds to Hydrazo Compounds
Authors: Sridhara M.B. , Srinivasa G.R. , Gowda D. Channe
Published: December 2009

The reduction of azo compounds with magnesium powder as catalyst in the presence of ammonium chloride at room temperature in methanol leads to hydrazo compounds.
One-pot Synthesis of Some New Spiro 6H-indolo[b-1,2]quinazoline-12-one-[1,2,4]triazolines
Authors: Azizian Javad , Mohammadizadeh Mohammad R. , Javadi Maryam , Mohammadi Ali A. , Karimi Ali R.
Published: December 2009

The title compounds 3a–g were prepared by the cycloaddition reaction of nitrilimines and tryptanthrinimines using conventional methods and in good yields.
Studies with Functionally Substituted Enamines: Synthesis of New Aminoazolo-Pyrimidines and -1,2,4-Triazines
Authors: Ghozlan Said Ahmed Soliman , Abdelhamid Ismail Abdelshafy , Gaber Hatem , Elnagdi Mohamed Hilmy
Published: December 2009

3-Aminoacrylonitrile derivatives (1d–g) coupled with aromatic and heteroaromatic diazonium salts yielding arylhydrazonals and pyrazolo[5,1-c]triazines. The enaminonitriles 1d–g condensed to form dienes 6a–c on reflux in acetic acid. The latter underwent Diels-Alder type addition to naphthoquinone. Aminopyrazolopyrimidines were obtained from reaction of 1d–g with heteroaromatic aminoazoles. Enaminonitrile 1d formed pyran 21 with benzylidene malononitrile, and dihydropyrimidine 22 with benzaldehyde and urea.
P2O5 / SiO2 as a mild and efficient reagent for acylation of alcohols, phenols and amines under solvent-free conditions
Authors: Eshghi Hossein , Shafieyoon Parvaneh
Published: December 2009

P2O5 / SiO2 is a highly efficient reagent for the acetylations of a variety of alcohols, phenols and amines with acetic anhydride under solvent-free conditions. Primary, secondary, allylic and benzylic alcohols, diols and phenols with electron-donating or withdrawing substituents can be easily acetylated in good to excellent yield.
Stereoselective synthesis of 1,3-enynyltellurides via palladium catalysed cross-coupling reaction of (E)-α-iodovinyltellurides
Authors: Cai Mingzhong , Chen Junmin
Published: December 2009

(E)-α-Iodovinyltellurides undergo a direct coupling reaction with terminal alkynes in the presence of [Pd(PPh3)4] and CuI catalysts in pyrrolidine at room temperature to give 1,3-enynyltellurides in good yields.
Synthesis and X-ray structure conformation of novel unsymmetrical 1,4-dihydropyridine
Authors: Mahendra Madegowda , Doreswamy Beeranahally H. , Manvar Dinesh , Patel Gautam , Naliapara Yogesh , Dholariya Kinnari , Shah Anamik , Anandalwar Sridhar M. , Prasad Javaregowda S.
Published: December 2009

Methyl 2,6-dimethyl-5-(2-methylphenylcarbamoyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-2-carboxylate (3) was prepared by known Hantzch method and its structure was elucidated by X-ray diffraction method.
A new route to β-trifluoromethylenaminones
Authors: Zouaoui Emna , Rezgui Farhat , Gaïed Mohamed Moncef EL
Published: December 2009

New β-trifluoromethylenaminones have been prepared in moderate to good yields by regioselective reaction of a variety of primary and secondary amines on the corresponding β-chlorovinyl-β-trifluoromethylketone.
Synthesis of some new pyridazine, 1,2,4-triazine and 1,3,4-thiadiazole derivatives
Authors: Farag Ahmad M. , Dawood Kamal M. , Abdel-Aziz Hatem A.
Published: December 2009

3-(2-Furyl)-3-oxo-propanenitrile (1) reacts with some phosphorus ylides to afford new pyridazine and 1,2,4-triazine derivatives. Reaction of 1 with some heterocyclic diazonium salts afforded fused heterocyclic systems with bridgehead nitrogen atoms.
The use of free energy relationships to rationalise structural and solvent effects on the photoreduction of cobalt(III) complexes in aqueous organic solvent medium
Authors: Elango K.P.
Published: December 2009

Quantum yields for the photoreduction of a series of CoIII complex ions, [CoClen2 (RC6H4NH2)]2+ where R=p-OMe, p-OEt, p-Me, m-Me, H and p-F using a low pressure Hg vapour lamp (254 nm) in aqueous ethanol mixtures (15–40% v/v organic cosolvent), increase with increase in mole fraction of the cosolvent in the binary solvent mixture under investigation. The Hammett correlation is linear, affording negative reaction constants, which indicate that the excited state is electron deficient. Correlation of the quantum yield data with Kamlet–Taft's solvatochromic parameters indicates that the specific solvent–solute interactions play a dominant role in governing the reactivity.
Synthesis of 1-H-inden-1-one derivatives via the reaction of Shiff bases with carbon suboxide
Authors: Casu Laura , Cottiglia Filippo , Bonsignore Leonardo
Published: December 2009

1-oxo-N-phenyl-1H-inden-2-carbamide were obtained by reaction of Schiff bases with carbon suboxide (C3O2) in presence of AlCl3.
Bromination of carbon–carbon double bonds involving oxidation of NaBr in an ionic liquid
Authors: Ying Taokei , Bao Weiliang , Zhang Yongmin
Published: December 2009

Bromination of alkenes has been conducted in a room temperature ionic liquid {[bmim]+ CCl3COO– (1–butyl–3–methylimidazolium trichloroacetate)} involving the oxidation of NaBr by hydrogen peroxide with no catalyst. Comparatively fast reactions, good yields and the atom economic nature make this environmentally benign reaction an appealing procedure for alkene and alkyne bromination.
Synthesis of imidazo[1,2-a][1,8]naphthyridines under microwave irradiation
Authors: Mogilaiah K. , Reddy G. Randheer , Reddy Ch. Srinivas
Published: December 2009

A convenient synthesis of 4-aryl-2-phenylimidazo[1,2-a][1,8]naphthyridines (3), by cyclo condensation of 3-aryl-1-(2-oxophenylethyl)-1,8-naphthyridin-2-ones (2) with ammonium acetate in glacial acetic acid under microwave irradiation, is described.
A facile synthesis of novel 2-acetyl-1-hydroxycarbazoles– synthesis of biogenetically possible 2-phenyl-4-oxopyrano[2,3-a]carbazoles and annelated carbazoles
Authors: Vandana  , Prasad Karnam Jayarampillai Rajendra
Published: December 2009

Using trifluoroacetic acid as the condensing agent, the synthesis of novel 2-acetyl-1-hydroxycarbazoles has been achieved in moderate yield from 1-hydroxycarbazoles and acetyl chloride. Further, 2-acetyl-1-hydroxycarbazoles on base condensation with benzaldehyde followed by Prevost reaction with I2 – AgOAc in glacial AcOH yielded 2,3-dihydro-3-iodo-2-phenyl-4-oxopyrano[2,3-a]carbazoles which upon dehydroiodination afforded the biogenetically possible 2-phenyl-4-oxopyrano[2,3-a]carbazoles. Also, 2-acetyl-1-hydroxycarbazoles have been employed as synthones for the synthesis of annelated carbazoles viz. 3-methyl-pyrazolino- and 3-methyl-isoxazolo- [2,3-a]carbazoles.
SmI2-mediated facile syntheses of N-(2,2-dichlorovinyl)amides from acetates of chloralamide
Authors: Jian Li , Wang Xiaoxia , Zhang Yongmin
Published: December 2009

Samarium diiodide-mediated elimination reaction provides a simple and general method to synthesise N-(2, 2-dichlorovinyl)amides 4 from acetates of chloralamides 3 in excellent yields. This novel reaction proceeds readily within a few minutes at room temperature.
Clay-Mediated Reaction of Indoles with Cyclohexane-1,3-Diones: An Expedient Route to Indolylcyclohexenones
Authors: Chakrabarty Manas , Kundu Taraknath , Harigaya Yoshihiro
Published: December 2009

Indoles (1a–e) react with cyclohexane-1,3-diones (2a–c) on montmorillonite K10 clay at 60–70 °C to furnish the corresponding 3-(3′-indolyl)cyclohex-2-en-1-ones (5a–e, 6a–e, 7b–e) in 27–75% yields in 2.5–4 h.
Triphenylphosphine-mediated synthesis of 5-oxo-2,5-dihydrofurans through the reaction of dialkyl acetylenedicarboxylates and butane-2,3-dione
Authors: Yavari Issa , Amiri Rahebeh , Haghdadi Mina
Published: December 2009

Dimethyl or diethyl acetylenedicarboxylates undergo smooth reactions with butane-2,3-dione in the presence of triphenylphosphine to yield highly functionalised 5-oxo-2,5-dihydrofurans; using di-t-butyl acetylenedicarboxylate affords a cyclopentenone derivative.
Microwave-Assisted Coupling of Carbonyl Compound: An Efficient Synthesis of Olefin
Authors: Ramana M.M.V. , Singh B.K.D. , Parihar J.A.
Published: December 2009

Self-coupling of various ketones and aldehyde as well as mixed coupling of ketones employing TiCl4/ Zn under microwave irradiation has been carried out to afford the corresponding olefins.
One pot Suzuki coupling – Wittig olefination reactions
Authors: Thiemann Thies , Watanabe Masataka , Tanaka Yasuko , Mataka Shuntaro
Published: December 2009

Bromoarylcarbaldehydes and bromothienylcarbaldehydes undergo Suzuki cross coupling and Wittig reactions in a one pot procedure to give olefins with extended pi systems. Dihaloarenes can be transformed in a double Wittig – / double Suzuki cross coupling reaction to yield functionalised terphenyls.
Non-acid catalytic acetalisation of aldehydes with diols in ionic liquids
Authors: Zhang Fan , Xu Dan-Qian , Luo Shu-Ping , Liu Bao-You , Du Xiao-Hua , Xu Zhen-Yuan
Published: December 2009

The acetalisation of aldehydes with diols to corresponding 1,3-dioxolanes has been accomplished using ionic liquids as catalyst and reaction media. In the reaction process the removal of water produced and other catalysts were not necessary. High conversion and good selectivity were obtained when using HMImBF4, which could be easily recycled and reused.
Steric Factors in the Preparation of Nitrostilbenes
Authors: Hanson James R. , Hitchcock Peter B. , Saberi Hamid
Published: December 2009

The influence of an adjacent methyl group on the conformation of an aromatic nitro group and the consequent effect on the ease of synthesis of nitrostilbenes, has been examined using X-ray crystallographic studies to reveal the extent of the rotation of the nitro group.
A Mild and Selective Method for the Conversion of Oximes into Ketones and Aldehydes by the Use of N-Bromophthalimide
Authors: Khazaei Ardeshir , Manesh Abbas Amini , Rostami Amin
Published: December 2009

N-Bromophthalimide has been found to be an efficient and selective reagent for the mild oxidative cleavage of oximes to yield their corresponding carbonyl compounds in good to excellent yields.
Microwave Assisted Dealkylation of Alkyl Aryl Ethers in Ionic Liquids
Authors: Chauhan Shive M. S. , Jain Nidhi
Published: December 2009

Alkyl aryl ethers undergo selective dealkylation in 1-butyl pyridinium bromide and 1-butyl-3-methyl imidazolium bromide ionic liquids under microwave irradiation to give the corresponding phenols in high yields. The ionic liquids serve the dual purpose of solvent as well as reagent and allow easy isolation of products.
Regioselective Glucosylation of Oxyresveratrol by Cell Suspension Cultures of Solanum Mammosum
Authors: Hakim Euis H. , Achmad Sjamsul A. , Aimi Norio , Indrayanto Gunawan , Kitajima Mariko , Makmur Lukman , Surya Merry D. , Syah Yana M. , Takayama Hiromitsu
Published: December 2009

The glucosylation of oxyresveratrol by cell suspension cultures of Solanum mammosum has been investigated.
Synthesis and Spectral Properties of New Quinoxalines with Electron Donor Groups
Authors: Jaung Jae-Yun
Published: December 2009

Three new 6,7-bis(3-methylbutyloxy)-2,3-(2-phenylethenyl)quinoxalines with groups of different electron-donating ability on the phenyl rings were prepared. The substituent effects on the absorption spectra of these fluorescent dyes in solution were studied.
A Convenient Synthesis of 2-Amino-3-Cyano-4-Aryl-9,10-Dihydrobenzo[f] Chromene Derivatives Catalysed by KF/Al2O3
Authors: Wang Xiang-shan , Shi Da-qing , Wei Xian-yong , Zong Zhi-min
Published: December 2009

A series of 2-amino-3-cyano-4-aryl-9,10-dihydrobenzo[ f]chromene derivatives were synthesised from arylaldehyde, malononitrile with 7-methoxyl-1,2,3,4-tetrahydronaphthalene-2-one in ethyl alcohol at refluxing temperature catalysed by KF-Al2O3. The structure of the product was confirmed by X-ray analysis.
A New ent-Kaurane Deterpenoid from Isodon Excisoides (Sun ex C. H. Hu) C. Y. Wu et H. W. Li
Authors: Ding Lan , Wang Han , Liu Guoan , Yang Dongjuan
Published: December 2009

A new ent-kaurane diterpenoid, excisoidesin (1), was isolated from the acetone extract of the leaves of Isodon excisoides (Sun ex C. H. Hu) C. Y. Wu et H. W. Li, along with kamebacetal B (2), glaucocalyxin A (3), leukamenin E (4), kamebanin (5) and wangzaozin A (6). The structure of the new compound was determined as 7α,14β,18-trihydroxy- ent-kaur-16-en-3,15-dione by spectroscopic methods. Compound 1–6 showed significant cytotoxic activity against human tumor Bel-7402 cells.
Novel Synthesis of Calix[n]Arene Amide Supramolecular Receptor
Authors: Yan Chaoguo , An Lin , Wang Yunyan , Sun Jing
Published: December 2009

In the system of K2CO3/KI/acetone, eight p-tert-butylcalix[ n]arene amide products ( n = 6, 8) were prepared by the O-alkylation of calixarenes with N, N-dialkyl α-chloroacetamides in high yields (HNR2 = dipropylamine, isopropylamine, pepridine, morphine). These amide products can also be synthesised by the amination reaction of the correspond ethyl calix[n]aryl acetates.
Synthetic approaches to 1,2,5-benzothiadiazepine 1,1-dioxides – sulfonamide analogues of the 1,4-benzodiazepines
Authors: Hemming Karl , Loukou Christina
Published: December 2009

Synthetic approaches to the 1,2,5-benzothiadiazepine 1,1-dioxides, sulfonamide analogues of the 1,4-benzodiazepines, are reviewed. The review incorporates the synthesis of bicyclic, tricyclic and tetracyclic systems, and includes approaches to sulfonamide analogues of the antitumour pyrrolobenzodiazepines, sulfonamide analogues of the tricyclic non-nucleosidic reverse transcriptase inhibiting benzodiazepines (such as nevirapine), and other systems of biological interest. Details of the reactions and biological activity of the 1,2,5-benzothiadiazepines are also given.
Synthesis of cis, cis-1,3,5-trisubstituted cyclohexane based chelators with polyfunctional pendant arms
Authors: Baral Minati , Kanungo B.K. , Moore Peter
Published: December 2009

Some novel organic compounds of the type: cis, cis-1,3,5-tris(X)cyclohexane, where X= –CONH(CH2)2NH2, –CONH(CH2)3NH2, –CONH(CH2)2NCH –C6H4OH, CONH(CH2)3NCHC6H4OH, which are expected to function as potential polydentate chelators have been synthesised from 1,3,5-benzenetricarboxylic acid through multi-steps reactions. 1,3,5-benzenetricarboxylic acid was reduced to cis, cis-1,3,5-tris(ethylcarboxylate)cyclohexane, which on reaction with excess of 1,2-diaminoethane and 1,2-diaminopropane afforded two new compounds. Condensation of the obtained derivatives with three equivalents of salicylaldehyde resulted the formation of two new Schiff base compounds. All the compounds were characterised by a combination of elemental analysis, mass, IR, UV-Vis, 1H NMR and 13C NMR spectroscopy.
Microwave-assisted synthesis of quinolones and 4H-1,4-benzo thiazine 1,1-dioxides
Authors: Charris Jaime , Barazarte Arthur , Domínguez José , Gamboa Neira
Published: December 2009

A rapid method for the preparation of N-aryl-2-methylthio-4-oxo-1,4-dihydro quinoline-3-carbonitriles (2a–e) and N-aryl-3-methylthio-4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxides (2f–o) is reported. The cyclization is accelerated by microwave irradiation under solvent free conditions in the presence of K2CO3.
Synthesis of new stable crystalline zwitterionic products from the reactions of 1-methylimidazole, acetylenic esters and strong cyclic CH-acids
Authors: Teimouri Mohammad Bagher , Bazhrang Reihane
Published: December 2009

The reactive 1:1 intermediate produced in the reaction between 1-methyl imidazole and dialkyl acetylenedicarboxylates was trapped by strong cyclic CH-acids such as N,N′-dimethylbarbituric acid, Meldrum's acid, cyclohexan-1, 3-dione, indan-1,3-dione, cyclopentan-1,3-dione and tetronic acid to yield stable 1,4-diionic imidazolium betaines in excellent yields.
Two mild methods for synthesis of α,β–unsaturated cyanoesters
Authors: Zhang Ming , Zhang Ai-Qin , Deng Zhi-Hong
Published: December 2009

α,β–Unsaturated cyanoesters can be prepared by reaction of aldehydes and ethyl cyanoacetate catalysed by CaCl2/Et3N or NaOH at room temperature.
Synthesis of Doubly Azacrowned Thiacalixarenes
Authors: Jin Yan , Li Xiong , Gong Shuling , Chen Yuanyin
Published: December 2009

Under selected conditions, 1,2:3,4-doubly crowned p-tert-butyl-thiacalix[4]arene in cone conformation and 1,3:2, 4-doubly crowned p-tert-butyl-thiacalix[4]arene in 1,3-alternate conformation were obtained through aminolysis in high to good yield, respectively.
The Purification of Triethylenetetramine and Its Dihydrochloride for the Treatment of Wilson's Disease
Authors: Purchase Rupert
Published: December 2009

A method for the purification of triethylenetetramine and its dihydrochloride for use in the treatment of Wilson's disease is reported.
VCl3 Catalysed Efficient Synthesis of Bis(indolyl)methanes
Authors: Rajitha Bavanthula , Reddy Penthala Narsimha , Kumar Buridapad Sunil , Sreenivasulu Neeladri , Reddy Yerram Reddy Thirupathi
Published: December 2009

VCl3 is found to be an efficient catalysts for the electrophilic substitution reaction of indoles with aromatic aldehydes in dichloromethane to afford the corresponding bis(indolyl)methanes in excellent yields at room temperature.