bluuebunny/crossref_metadata_2025 huggingface dataset:
Unraveling the Keratin Expression in Oral Leukoplakia: A Scoping Review
Authors: Murthy O Guru , Lau Jeremy , Balasubramaniam Ramesh , Frydrych Agnieszka M. , Kujan Omar
Published: May 2024

Intermediate filaments are one of three polymeric structures that form the cytoskeleton of epithelial cells. In the epithelium, these filaments are made up of a variety of keratin proteins. Intermediate filaments complete a wide range of functions in keratinocytes, including maintaining cell structure, cell growth, cell proliferation, cell migration, and more. Given that these functions are intimately associated with the carcinogenic process, and that hyperkeratinization is a quintessential feature of oral leukoplakias, the utility of keratins in oral leukoplakia is yet to be fully explored. This scoping review aims to outline the current knowledge founded on original studies on human tissues regarding the expression and utility of keratins as diagnostic, prognostic, and predictive biomarkers in oral leukoplakias. After using a search strategy developed for several scientific databases, namely, PubMed, Scopus, Web of Science, and OVID, 42 papers met the inclusion and exclusion criteria. One more article was added when it was identified through manually searching the list of references. The included papers were published between 1989 and 2024. Keratins 1–20 were investigated in the 43 included studies, and their expression was assessed in oral leukoplakia and dysplasia cases. Only five studies investigated the prognostic role of keratins in relation to malignant transformation. No studies evaluated keratins as a diagnostic adjunct or predictive tool. Evidence supports the idea that dysplasia disrupts the terminal differentiation pathway of primary keratins. Gain of keratin 17 expression and loss of keratin 13 were significantly observed in differentiated epithelial dysplasia. Also, the keratin 19 extension into suprabasal cells has been associated with the evolving features of dysplasia. The loss of keratin1/keratin 10 has been significantly associated with high-grade dysplasia. The prognostic value of cytokeratins has shown conflicting results, and further studies are required to ascertain their role in predicting the malignant transformation of oral leukoplakia.
Task-Adaptive Multi-Source Representations for Few-Shot Image Recognition
Authors: Liu Ge , Zhang Zhongqiang , Fang Xiangzhong
Published: May 2024

Conventional few-shot learning (FSL) mainly focuses on knowledge transfer from a single source dataset to a recognition scenario with only a few training samples available but still similar to the source domain. In this paper, we consider a more practical FSL setting where multiple semantically different datasets are available to address a wide range of FSL tasks, especially for some recognition scenarios beyond natural images, such as remote sensing and medical imagery. It can be referred to as multi-source cross-domain FSL. To tackle the problem, we propose a two-stage learning scheme, termed learning and adapting multi-source representations (LAMR). In the first stage, we propose a multi-head network to obtain efficient multi-domain representations, where all source domains share the same backbone except for the last parallel projection layers for domain specialization. We train the representations in a multi-task setting where each in-domain classification task is taken by a cosine classifier. In the second stage, considering that instance discrimination and class discrimination are crucial for robust recognition, we propose two contrastive objectives for adapting the pre-trained representations to be task-specialized on the few-shot data. Careful ablation studies verify that LAMR significantly improves representation transferability, showing consistent performance boosts. We also extend LAMR to single-source FSL by introducing a dataset-splitting strategy that equally splits one source dataset into sub-domains. The empirical results show that LAMR can achieve SOTA performance on the BSCD-FSL benchmark and competitive performance on mini-ImageNet, highlighting its versatility and effectiveness for FSL of both natural and specific imaging.
Climate as a Predictive Factor for Invasion: Unravelling the Range Dynamics of Carpomya vesuviana Costa
Authors: Feng Chuangju , Guo Facheng , Gao Guizhen
Published: May 2024

Invasive alien species (IAS) significantly affect global native biodiversity, agriculture, industry, and human health. Carpomya vesuviana Costa, 1854 (Diptera: Tephritidae), a significant global IAS, affects various date species, leading to substantial economic losses and adverse effects on human health and the environment. This study employed biomod2 ensemble models, multivariate environmental similarity surface and most dissimilar variable analyses, and ecological niche dynamics based on environmental and species data to predict the potential distribution of C. vesuviana and explore the environmental variables affecting observed patterns and impacts. Compared to native ranges, ecological niche shifts at invaded sites increased the invasion risk of C. vesuviana globally. The potential geographical distribution was primarily in Asia, Africa, and Australia, with a gradual increase in suitability with time and radiation levels. The potential geographic distribution centre of C. vesuviana is likely to shift poleward between the present and the 2090s. We also show that precipitation is a key factor influencing the likely future distribution of this species. In conclusion, climate change has facilitated the expansion of the geographic range and ecological niche of C. vesuviana, requiring effective transnational management strategies to mitigate its impacts on the natural environment and public health during the Anthropocene. This study aims to assess the potential threat of C. vesuviana to date palms globally through quantitative analytical methods. By modelling and analysing its potential geographic distribution, ecological niche, and environmental similarities, this paper predicts the pest’s dispersal potential and possible transfer trends in geographic centres of mass in order to provide prevention and control strategies for the global date palm industry.
The Surgical Stress Response and Anesthesia: A Narrative Review
Authors: Ivascu Robert , Torsin Ligia I. , Hostiuc Laura , Nitipir Cornelia , Corneci Dan , Dutu Madalina
Published: May 2024

The human physiological response “to stress” includes all metabolic and hormonal changes produced by a traumatic event at the micro or macro cellular levels. The main goal of the body’s first response to trauma is to keep physiological homeostasis. The perioperative non-specific adaptation response can sometimes be detrimental and can produce systemic inflammatory response syndrome (SIRS), characterized by hypermetabolism and hyper catabolism. We performed a narrative review consisting of a description of the surgical stress response’s categories of changes (neurohormonal and immunological response) followed by reviewing methods found in published studies to modulate the surgical stress response perioperatively. We described various preoperative measures cited in the literature as lowering the burden of surgical trauma. This article revises the anesthetic drugs and techniques that have an impact on the surgical stress response and proven immune-modulatory effects. We also tried to name present knowledge gaps requiring future research. Our review concludes that proper preoperative measures, adequate general anesthetics, multimodal analgesia, early postoperative mobilization, and early enteral nutrition can decrease the stress response to surgery and ease patient recovery. Anesthetics and analgesics used during the perioperative period may modulate the innate and adaptive immune system and inflammatory system, with a consecutive impact on cancer recurrence and long-term outcomes.
Stereotactic Body Radiotherapy in Recurrent and Oligometastatic Head and Neck Tumours
Authors: Tham Jodie L. M. , Ng Sweet Ping , Khor Richard , Wada Morikatsu , Gan Hui , Thai Alesha A. , Corry June , Bahig Houda , Mäkitie Antti A. , Nuyts Sandra , De Bree Remco , Strojan Primož , Ng Wai Tong , Eisbruch Avraham , Chow James C. H. , Ferlito Alfio
Published: May 2024

The treatment of head and neck cancers (HNCs) encompasses a complex paradigm involving a combination of surgery, radiotherapy, and systemic treatment. Locoregional recurrence is a common cause of treatment failure, and few patients are suitable for salvage surgery. Reirradiation with conventional radiation techniques is challenging due to normal tissue tolerance limits and the risk of significant toxicities. Stereotactic body radiotherapy (SBRT) has emerged as a highly conformal modality that offers the potential for cure while limiting the dose to surrounding tissue. There is also growing research that shows that those with oligometastatic disease can benefit from curative intent local ablative therapies such as SBRT. This review will look at published evidence regarding the use of SBRT in locoregional recurrent and oligometastatic HNCs.
Once upon a Time, There Was a Piece of Wood: Present Knowledge and Future Perspectives in Fungal Deterioration of Wooden Cultural Heritage in Terrestrial Ecosystems and Diagnostic Tools
Authors: Isola Daniela , Lee Hyun-Ju , Chung Yong-Jae , Zucconi Laura , Pelosi Claudia
Published: May 2024

Wooden Cultural Heritage (WCH) represents a significant portion of the world’s historical and artistic heritage, consisting of immovable and movable artefacts. Despite the expertise developed since ancient times to enhance its durability, wooden artefacts are inevitably prone to degradation. Fungi play a pivotal role in the deterioration of WCH in terrestrial ecosystems, accelerating its decay and leading to alterations in color and strength. Reviewing the literature of the last 25 years, we aimed to provide a comprehensive overview of fungal diversity affecting WCH, the biochemical processes involved in wood decay, and the diagnostic tools available for fungal identification and damage evaluation. Climatic conditions influence the occurrence of fungal species in threatened WCH, characterized by a prevalence of wood-rot fungi (e.g., Serpula lacrymans, Coniophora puteana) in architectural heritage in temperate and continental climates and Ascomycota in indoor and harsh environments. More efforts are needed to address the knowledge fragmentation concerning biodiversity, the biology of the fungi involved, and succession in the degradative process, which is frequently centered solely on the main actors. Multidisciplinary collaboration among engineers, restorers, and life sciences scientists is vital for tackling the challenges posed by climate change with increased awareness. Traditional microbiology and culture collections are fundamental in laying solid foundations for a more comprehensive interpretation of big data.
Public Service Media in the Platform Era: The Cases of Britain, Denmark, and Greece
Authors: Karadimitriou Achilleas , Papathanassopoulos Stylianos
Published: May 2024

Public service media (PSM) are grappling with structural shifts in the audio-visual sector, notably the shift of audiences towards over-the-top (OTT) or subscription video-on-demand (SVOD) services. They have also heavily invested in online platforms, adapting their policies to engage digital users on their video-on-demand (VOD) platforms. This paper assesses PSM policies in Britain, Denmark, and Greece, examining initiatives regarding adaptation to the digital era. It explores whether they implement new strategies to expand their digital reach. Data from policy documents and interviews with BBC, DR, and ERT leading executives inform the analysis. Findings showed varied responses among PSM organisations, influenced by market dynamics and the evolution of broadcasting traditions.
Overall Polyp Detection Rate as a Surrogate Measure for Screening Efficacy Independent of Histopathology: Evidence from National Endoscopy Database
Authors: Aloysius Mark , Goyal Hemant , Nikumbh Tejas , Shah Niraj , Aswath Ganesh , John Savio , Bapaye Amol , Guha Sushovan , Thosani Nirav
Published: May 2024

Adenoma detection rate (ADR) is challenging to measure, given its dependency on pathology reporting. Polyp detection rate (PDR) (percentage of screening colonoscopies detecting a polyp) is a proposed alternative to overcome this issue. Overall PDR from all colonoscopies is a relatively novel concept, with no large-scale studies comparing overall PDR with screening-only PDR. The aim of the study was to compare PDR from screening, surveillance, and diagnostic indications with overall PDR and evaluate any correlation between individual endoscopist PDR by indication to determine if overall PDR can be a valuable surrogate for screening PDR. Our study analyzed a prospectively collected national endoscopy database maintained by the National Institute of Health from 2009 to 2014. Out of 354,505 colonoscopies performed between 2009–2014, 298,920 (n = 110,794 average-risk screening, n = 83,556 average-risk surveillance, n = 104,770 diagnostic) met inclusion criteria. The median screening PDR was 25.45 (IQR 13.15–39.60), comparable with the median overall PDR of 24.01 (IQR 11.46–35.86, p = 0.21). Median surveillance PDR was higher at 33.73 (IQR 16.92–47.01), and median diagnostic PDR was lower at 19.35 (IQR 9.66–29.17), compared with median overall PDR 24.01 (IQR 11.46–35.86; p < 0.01). The overall PDR showed excellent concordance with screening, surveillance, and diagnostic PDR (r > 0.85, p < 0.01, 2-tailed). The overall PDR is a reliable and pragmatic surrogate for screening PDR and can be measured in real time, irrespective of colonoscopy indication.
(Hetero)Arene Ring-Fused [1,2,4]Triazines
Authors: Teymouri Mahshid , Pietrzak Anna , Bartos Paulina
Published: May 2024

Synthetic access to a five (hetero)arene ring-fused 3-phenyl[1,2,4]triazines is described. The resulting compounds were characterized via 1H and 13C NMR, IR, UV–vis spectroscopy and HRMS. The structure of 3-phenyl[1,2,4]triazino[5,6-c]quinoline was unambiguously confirmed by single crystal XRD.
Gelatin–Zinc Carrier as a New Method of Targeted and Controlled Release of Risedronate
Authors: Reczkowski Jakub , Długosz Maria , Ratajczak Maria , Voelkel Adam , Sandomierski Mariusz
Published: May 2024

The essence of drug delivery is to use an appropriate carrier that delivers the active substance to the appropriate pathogenic site at a specific time. This study aims to develop a novel drug carrier characterized by the controlled and targeted release of risedronate (RSD). The search for new routes to deliver RSD is important because oral delivery has many disadvantages. The carrier proposed in this work is composed of gelatin, polyphosphates, and zinc. The zinc contained in the carrier is responsible for coordinating the drug. The resulting material releases RSD in a controlled manner. The rate of delivery of the substance to the body depends on the pH of the environment. This study investigated the delivery of RSD in a neutral environment, where the process exhibited a prolonged and consistent release rate. This process has also been studied in an acidic environment, which accelerates the release of the drug. Mixed-environment studies were also conducted. Initially, the drug was released in a neutral environment, and then the conditions rapidly changed to acidic. In this case, the carrier demonstrated high stability and controlled release, adapting the rate of drug release to the prevailing environmental conditions. The presented results indicate the great potential of the new gelatin-based carrier in the delivery of risedronate.
The Effects of Lignin on the Thermal and Morphological Properties and Damage Mechanisms after UV Irradiation of Polypropylene Biocomposites Reinforced with Flax and Pine Fibres: Acoustic Emission Analysis
Authors: Belouadah Zouheyr , Nasri Khaled , Toubal Lotfi
Published: May 2024

This study investigates the impact of lignin on the durability and performance of polypropylene-based biocomposites (PP–flax and PP–pine) under environmental stresses such as UV radiation and moisture. The findings indicate that pine fibres, with their higher lignin content, are significantly more resistant to thermal degradation than flax fibres. Differential scanning calorimetry (DSC) showed that lignin influences crystallinity and melting temperatures across the composites, with variations corresponding to fibre type. Acoustic emissions analysis revealed that increasing the lignin content in pine fibres effectively reduces surface microcracks under UV exposure. Overall, these results underscore the importance of fibre composition in improving the performance and longevity of biocomposites, making them better suited for durable construction applications.
Optimizing the Sintering Conditions of (Fe,Co)1.95(P,Si) Compounds for Permanent Magnet Applications
Authors: Yiderigu Jin , Yibole Hargen , Bao Lingbo , Bao Lingling , Guillou François
Published: May 2024

(Fe,Co)2(P,Si) quaternary compounds combine large uniaxial magnetocrystalline anisotropy, significant saturation magnetization and tunable Curie temperature, making them attractive for permanent magnet applications. Single crystals or conventionally prepared bulk polycrystalline (Fe,Co)2(P,Si) samples do not, however, show a significant coercivity. Here, after a ball-milling stage of elemental precursors, we optimize the sintering temperature and duration during the solid-state synthesis of bulk Fe1.85Co0.1P0.8Si0.2 compounds so as to obtain coercivity in bulk samples. We pay special attention to shortening the heat treatment in order to limit grain growth. Powder X-ray diffraction experiments demonstrate that a sintering of a few minutes is sufficient to form the desired Fe2P-type hexagonal structure with limited secondary-phase content (~5 wt.%). Coercivity is achieved in bulk Fe1.85Co0.1P0.8Si0.2 quaternary compounds by shortening the heat treatment. Surprisingly, the largest coercivities are observed in the samples presenting large amounts of secondary-phase content (>5 wt.%). In addition to the shape of the virgin magnetization curve, this may indicate a dominant wall-pining coercivity mechanism. Despite a tenfold improvement of the coercive fields for bulk samples, the achieved performances remain modest (HC ≈ 0.6 kOe at room temperature). These results nonetheless establish a benchmark for future developments of (Fe,Co)2(P,Si) compounds as permanent magnets.
Dynamic Thermal Response of Multiple Interface Cracks between a Half-Plane and a Coating Layer under General Transient Temperature Loading
Authors: Nourazar Mahsa , Yang Weilin , Chen Zengtao
Published: May 2024

This paper explores the thermal behavior of multiple interface cracks situated between a half-plane and a thermal coating layer when subjected to transient thermal loading. The temperature distribution is analyzed using the hyperbolic heat conduction theory. In this model, cracks are represented as arrays of thermal dislocations, with densities calculated via Fourier and Laplace transformations. The methodology involves determining the temperature gradient within the uncracked region, and these calculations contribute to formulating a singular integral equation specific to the crack problem. This equation is subsequently utilized to ascertain the dislocation densities at the crack surface, which facilitates the estimation of temperature gradient intensity factors for the interface cracks experiencing transient thermal loading. This paper further explores how the relaxation time, loading parameters, and crack dimensions impact the temperature gradient intensity factors. The results can be used in fracture analysis of structures operating at high temperatures and can also assist in the selection and design of coating materials for specific applications, to minimize the damage caused by temperature loading.
Diabetic Nephropathy, Retinopathy, and Functional Hypogonadism in a Patient with MODY10: A Case Report
Authors: Ruiz-Urbaez Rossana , Villagómez-Estrada Mariela Viviana , Reyes-Silva Carlos , Quishpe-López Darlyng , Males-Maldonado David , Salazar-Vega Jorge , Gea-Izquierdo Enrique
Published: May 2024

(1) Background and objectives: Maturity-onset diabetes of the young (MODY) is a group of diabetes caused by gene defects related to insulin secretion. MODY1, MODY2, and MODY3 are the most common and account for approximately 80% of all cases. Other types are relatively rare. This study describes the clinical, analytical, and genetic characteristics of a patient with MODY10, and diabetic nephropathy, retinopathy, and functional hypogonadism diagnosis. (2) Materials and methods: A clinical case was analyzed and whole exome generation sequencing (WES) was used to detect mutations related to a monogenic variant. (3) Results: A seventeen-year-old male patient, who was diagnosed with apparent type 1 diabetes at the age of eight was started with insulin therapy. He came to the emergency room with glycemic decompensation, facial, and lower limb edema. During his evaluation, he had near-nephrotic range proteinuria of 2902 mg/24 h, a kidney ultrasound showing mild pyelocalyceal dilation, proliferative diabetic retinopathy, and was also diagnosed with functional hypogonadotropic hypogonadism. These comorbidities improved with adequate glycemic control. WES showed missense variant c.94G>A (p.Gly32Ser) in the INS gene, according to Clinvar corresponding to MODY10. It was a “de novo” variant not reported in his parents. (4) Conclusions: Monogenic diabetes (MD) is rare and MODY10 is among the less frequent types. MODY should be suspected in patients with type 1 phenotype with negative autoimmunity even in the absence of a family history of diabetes. To the best of our knowledge, we present here the first patient with these phenotypic traits of MODY10 reported in Latin America.
A Clinical Approach for the Removal of a Large Antral Pseudocyst with Simultaneous Maxillary Sinus Augmentation: A Case Series
Authors: Park Won-Bae , Shin Jina , Shin Seungil , Hong Ji-Youn
Published: May 2024

For a large benign lesion within the maxillary sinus, such as an antral pseudocyst, maxillary sinus floor augmentation is more commonly performed using a two-stage approach. This involves first removing the lesion, and then, re-entry following several months of healing. In this case series, we described the “one-bony-window” approach, which is a technical surgical modification of the previous one-stage approach, for simultaneous cyst removal and maxillary sinus floor augmentation. Four patients with large maxillary antral pseudocysts were included. The “one-bony-window” approach involves the preparation of a large window opening of approximately 15 mm × 20 mm at the lateral wall. A mesiodistally extended intentional perforation was made in the upper part of the exposed membrane to enhance the access for instrumentation. The antral pseudocyst was removed in its entirety without being deformed to prevent rupture or leakage of the cystic contents. Subsequent detachment and elevation of the Schneiderian membrane at the sinus floor significantly reduced the perforation site, and bone grafting with implant placement was performed simultaneously. This alleviated the need to surgically repair the perforation. The lateral opening was either uncovered or repositioned using bony window lids. Healing abutments were connected after six months, and the final prosthesis was placed after two months. At the 1-year follow-up, the antral pseudocysts had resolved with no specific recurrence, and the stability of the augmented sinus was maintained with excellent implant survival. Within the limitations of our findings, the “one-bony-window” technique can be suggested for the simultaneous removal of large antral pseudocysts and maxillary sinus floor augmentation with favorable clinical outcomes.
A Rare Case of Primary Pulmonary Diffuse Large B-Cell Lymphoma Transformed from Marginal Zone Mucosa-Associated Lymphoid Tissue Lymphoma
Authors: Kiełbowski Kajetan , Kordykiewicz Dawid , Jesionka Janusz , Wójcik Janusz , Ptaszyński Konrad , Kostopanagiotou Konstantinos , Waloszczyk Piotr , Wojtyś Małgorzata Edyta
Published: May 2024

Primary pulmonary lymphoma is a rare neoplasm characterized by the proliferation of lymphoid tissue affecting the lungs. The most common subtype is marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT). Rarely, a MALT lymphoma transforms into a diffuse large B-cell lymphoma (DLBCL). Treatment options include chemotherapy, radiotherapy, immunotherapy, and surgery. Here, we describe a patient with a primary pulmonary MALT lymphoma transforming into DLBCL. The purpose of this case report is to raise awareness of the relevant clinical and imaging features and to emphasize the need for a multidisciplinary approach to optimal management. In addition, we screened the PubMed and Embase databases for similar reports with a confirmed presence of transforming lymphoma within the lungs.
Implementation of Numerical Model for Prediction of Temperature Distribution for Metallic-Coated Firefighter Protective Clothing
Authors: Naeem Jawad , Mazari Adnan , Kus Zdenek , Havelka Antonin , Abdelkader Mohamed
Published: May 2024

The aim of this study is to predict the distribution of temperature at various positions on silver-coated firefighter protective clothing when subjected to external radiant heat flux. This will be helpful in the determination of thermal protective performance. Firefighter clothing consists of three layers, i.e., the outer shell, moisture barrier and thermal liner. The outer shell is the exposed surface, which was coated with silver particles through a physical vapor deposition process called magnetron sputtering. Afterwards, these uncoated and silver-coated samples were exposed to radiant heat transmission equipment at 10 kW/m2 as per the ISO 6942 standard. Silver-coated samples displayed better thermal protective performance as the rate of temperature rise in silver-coated samples slowed. Later, a numerical approach was employed, contemplating the impact of metallic coating on the exterior shell. The finite difference method was utilized for solving partial differential equations and the implicit method was employed to discretize the partial differential equations. The numerical model displayed a good prediction of the distribution of temperature at different nodes with respect to time. The comparison of time vs. temperature graphs at different nodes for uncoated and silver-coated samples acquired from numerical solutions showed similar patterns, as witnessed in the experimental results.
Metabolic Profiling for Unveiling Mechanisms of Kushenol F against Imiquimod-Induced Psoriasis with UHPLC/MS Analysis
Authors: Yang Xingxin , Cheng Jiaoli , Yin Xunqing , Ao Ting , He Xudong , Yang Yaqin , Lin Yuping , Chen Zhen
Published: May 2024

Psoriasis is a common chronic immune-mediated inflammatory skin disorder. Sophora flavescens Alt. (S. flavescens) has been widely acknowledged in the prevention and treatment of psoriasis. Kushenol F (KSCF) is a natural isopentenyl flavonoid extracted from the root of S. flavescens. We aimed to investigate the effect and mechanism of KSCF on imiquimod (IMQ)-induced psoriasis-like skin lesions in mice. A mouse model of psoriasis was induced with 5% IMQ for 5 days, and the mice were given KSCF dermally for 5 days. Changes in skin morphology, the psoriasis area, the severity index (PASI), and inflammatory factors of psoriasis-like skin lesions were evaluated. Metabolites in the psoriasis-like skin lesions were analyzed with ultra-high-performance liquid chromatography/mass spectrometry followed by a multivariate statistical analysis to identify the differential metabolites and metabolic pathway. The results of the present study confirmed that KSCF significantly reduced PASI scores, epidermal thickening, and epidermal cell proliferation and differentiation. KSCF also reduced the levels of interleukin (IL)-1β, IL-6, IL-8, IL-17A, IL-22, IL-23, and tumor necrosis factor (TNF)-α in the injured skin tissues while increasing IL-10 content. KSCF significantly regulated metabolites in the skin samples, and a total of 161 significant metabolites were identified. These differential metabolites involved sphingolipid and linoleic acid metabolism and steroid hormone biosynthesis. Collectively, KSCF inhibited the inflammatory response to prevent IMQ-induced psoriasis-like skin lesions in mice by call-backing the levels of 161 endogenous metabolites and affecting their related metabolic pathways. KSCF has the potential to be developed as a topical drug for treating psoriasis symptoms.
Iodophor-Catalyzed Disulfenylation of Amino Naphthalenes with Aryl Sulfonyl Hydrazines
Authors: Yuan Yutong , He Jing , Ma Xiaowei , Han Sheng , Liu Yan
Published: May 2024

An iodophor-catalyzed direct disulfenylation of amino naphthalenes with aryl sulfonyl hydrazines in water was developed. A series of aryl sulfides were obtained in moderate to excellent yields. The advantages of this green protocol were the simple reaction conditions (metal-free, water as the solvent, under air), the odorless and easily available sulfur reagent, the broad substrate scope, and gram-scale synthesis. Moreover, the potential application of aryl sulfides was exemplified by further transformations.
Green Extraction of Polyphenols from Elaeagnus angustifolia L. Using Natural Deep Eutectic Solvents and Evaluation of Bioactivity
Authors: Li Lu , Lv Jingjing , Wang Xiaoqin , Li Xiujun , Guo Dongqi , Wang Liling , Zhang Na , Jia Qinghua
Published: May 2024

In the study, natural deep eutectic solvents (NADESs) were used as alternatives to traditional chemical solvents for the extraction of polyphenols from Elaeagnus angustifolia L. Nine NADESs were tested for the first time and compared with ethanol and water (traditional solvents) regarding the extraction of phenolic compounds from E. angustifolia L. These solvents were particularly effective at extracting polyphenols, whose low water solubility usually requires high amounts of organic solvents. The solvent based on choline chloride and malonic acid provided optimal results and was selected for further optimization. The effects of material-to-liquid ratio, ultrasound time, and ultrasound temperature on the extraction efficiency were studied through single-factor experiments. These parameters were optimized by Box–Behnken design using response surface methodology. The optimal conditions identified were 49.86 g/mL of material-to-liquid ratio, 31.10 min of ultrasound time, and 62.35 °C of ultrasound temperature, resulting in a high yield of 140.30 ± 0.19 mg/g. The results indicated that the NADES extraction technique provided a higher yield than the conventional extraction process. The antioxidant activity of the extract of polyphenols from E. angustifolia L. was determined, and UPLC–IMS–QTOF–MS was used to analyze the phenolic compounds in it. The results revealed that the scavenging ability of 1,1-diphenyl-2-picryl-hydrazil and 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonate) extracted by NADES was higher than that of polyphenols extracted by water and ethanol. Furthermore, a total of 24 phenolic compounds were identified in the extract. To the best of our knowledge, this is the first study in which a green and efficient NADES extraction method has been used to extract bioactive polyphenols from E. angustifolia L., which could provide potential value in pharmaceuticals, cosmetics, and food additives.
Detection of Ascorbic Acid by Two-Dimensional Conductive Metal-Organic Framework-Based Electrochemical Sensors
Authors: Wang Shi , Li Ping , Wang Junyi , Gong Jun , Lu Helin , Wang Xiaobo , Wang Quan , Xue Ping
Published: May 2024

The realization of efficient and accurate detection of biomolecules has become a key scientific issue in the field of life sciences. With the rapid development of nanotechnology, electrochemical sensors constructed from the superior physical and chemical properties of nanomaterials show faster and more accurate detection. Among nanomaterials, two-dimensional conductive MOF (2D cMOF) is considered to be a star material in electrochemical sensors due to its remarkable conductivity, high porosity, and stability. In this paper, a Cu3(HHTP)2/SPE electrochemical sensor for the detection of ascorbic acid (AA) was constructed by modifying 2D cMOF (Cu3(HHTP)2) on the surface of the screen-printed electrode (SPE). The sensor exhibited excellent catalytic activity in the detection of AA, with a lower detection limit of 2.4 μmol/L (S/N = 3) and a wide linear range of 25–1645 μmol/L. This high catalytic activity can be attributed to the abundant catalytic sites in Cu3(HHTP)2 and the rapid electron transfer between Cu+ and Cu2+, which accelerates the oxidation of AA. This work lays a foundation for the subsequent development of MOFs with special electrochemical catalytic properties and the integration of 2D cMOF into intelligent electrical analysis devices.
Copper-Nanoparticle-Induced Neurotoxic Effect and Oxidative Stress in the Early Developmental Stage of Zebrafish (Danio rerio)
Authors: Liu Na , Tong Luyao , Li Kunjie , Dong Qiuxia , Jing Jieying
Published: May 2024

Copper nanoparticles (CuNPs) are extensively used in electronics, cosmetics, fungicides, and various other fields due to their distinctive qualities. However, this widespread usage can contribute to environmental contamination and heightened health risks for living organisms. Despite their prevalent use, the ecological impacts and biosafety of CuNPs remain inadequately understood. The present study aims to delve into the potential toxic effects of CuNPs on zebrafish (Danio rerio) embryos, focusing on multiple indexes such as embryonic development, neurotoxicity, oxidative stress, and inflammatory response. The results revealed a notable increase in the death rate and deformity rate, alongside varying degrees of decrease in hatching rate and heart rate following CuNPs exposure. Particularly, the frequency of spontaneous tail coiling significantly declined under exposure to CuNPs at concentrations of 500 µg/L. Furthermore, CuNPs exposure induced alterations in the transcriptional expression of GABA signaling pathway-related genes (gabra1, gad, abat, and gat1), indicating potential impacts on GABA synthesis, release, catabolism, recovery, and receptor binding. Additionally, CuNPs triggered oxidative stress, evidenced by disruption in superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities, along with elevated malondialdehyde (MDA) levels. This oxidative stress subsequently led to a proinflammatory cascade, as demonstrated by the increased transcriptional expression of inflammatory markers (il-1β, tnf-α, il-6, and il-8). Comparative analysis with copper ion (provided as CuCl2) exposure highlighted more significant changes in most indexes with CuCl2, indicating greater toxicity compared to CuNPs at equivalent concentrations. In conclusion, these findings provide valuable insights into the toxic effects of CuNPs on zebrafish embryo development and neurotransmitter conduction. Furthermore, they present technical methodologies for assessing environmental and health risks associated with CuNPs, contributing to a better understanding of their biosafety and ecological impact.
Advances in Nanoparticles in the Prevention and Treatment of Myocardial Infarction
Authors: Wei Qidong , Xiao Yifei , Du Lixin , Li Ya
Published: May 2024

Myocardial infarction (MI) is one of the most prevalent types of cardiovascular disease. During MI, myocardial cells become ischemic and necrotic due to inadequate blood perfusion, leading to irreversible damage to the heart. Despite the development of therapeutic strategies for the prevention and treatment of MI, their effects are still unsatisfactory. Nanoparticles represent a new strategy for the pre-treatment and treatment of MI, and novel multifunctional nanoparticles with preventive and therapeutic capabilities hold promise for the prevention and treatment of this disease. This review summarizes the common types and properties of nanoparticles, and focuses on the research progress of nanoparticles for the prevention and treatment of MI.
Equilibrium, Kinetic, and Diffusion Mechanism of lead(II) and cadmium(II) Adsorption onto Commercial Activated Carbons
Authors: Lach Joanna , Okoniewska Ewa
Published: May 2024

The adsorption of Pb(II) and Cd(II) on three commercial microporous activated carbons was analysed. Adsorption kinetics and statistics were investigated, and the results were described with different models. The highest values of the correlation coefficient R2 were obtained for the pseudo-second-order kinetics model for all ions tested and all sorbents used. The adsorption process was found to be determined by both diffusion in the liquid layer and intraparticle diffusion. The adsorption equilibrium is very well described by Langmuir, Temkin, Thoth or Jovanovic isotherm models. Based on the values of n from the Freundlich isotherm and KL from the Langmuir isotherm, the adsorption of cadmium and lead ions was found to be favourable. The highest monolayer capacities were obtained during the adsorption of lead ions (162.19 mg/g) and for cadmium (126.34 mg/g) for activated carbon WG-12. This carbon is characterised by the highest amount of acid functional groups and the largest specific surface area. The adsorption efficiency of the tested ions from natural water is lower than that from a model solution made from deionised water. The lowest efficiencies are obtained when the process occurs from highly mineralised water.
Physicochemical Characterization of Hydroxyapatite Hybrids with Meloxicam for Dissolution Rate Improvement
Authors: Maggi Lauretta , Friuli Valeria , Cerea Beatrice , Bruni Giovanna , Berbenni Vittorio , Bini Marcella
Published: May 2024

Organic–inorganic hybrids represent a good solution to improve the solubility and dissolution rates of poorly soluble drugs whose number has been increasing in the last few years. One of the most diffused inorganic matrices is hydroxyapatite (HAP), which is a biocompatible and osteoconductive material. However, the understanding of the hybrids’ functioning mechanisms is in many cases limited; thus, thorough physicochemical characterizations are needed. In the present paper, we prepared hybrids of pure and Mg-doped hydroxyapatite with meloxicam, a drug pertaining to the Biopharmaceutical Classification System (BCS) class II, i.e., drugs with low solubility and high permeability. The hybrids’ formation was demonstrated by FT-IR, which suggested electrostatic interactions between HAP and drug. The substitution of Mg in the HAP structure mainly produced a structural disorder and a reduction in crystallite sizes. The surface area of HAP increased after Mg doping from 82 to 103 m2g−1 as well as the pore volume, justifying the slightly high drug amount adsorbed by the Mg hybrid. Notwithstanding the low drug loading on the hybrids, the solubility, dissolution profiles and wettability markedly improved with respect to the drug alone, particularly for the Mg doped one, which was probably due to the main distribution of the drug on the HAP surface.
A Terahertz Metasurface Sensor Based on Quasi-BIC for Detection of Additives in Infant Formula
Authors: Sun Mingjun , Lin Jie , Xue Ying , Wang Weijin , Shi Shengnan , Zhang Shan , Shi Yanpeng
Published: May 2024

Prohibited additives in infant formula severely affect the health of infants. Terahertz (THz) spectroscopy has enormous application potential in analyte detection due to its rich fingerprint information content. However, there is limited research on the mixtures of multiple analytes. In this study, we propose a split ring metasurface that supports magnetic dipole bound states in the continuum (BIC). By breaking the symmetry, quasi-BIC with a high quality (Q) factor can be generated. Utilizing an angle-scanning strategy, the frequency of the resonance dip can be shifted, resulting in the plotting of an envelope curve which can reflect the molecular fingerprint of the analytes. Two prohibited additives found in infant formula, melamine and vanillin, can be identified in different proportions. Furthermore, a metric similar to the resolution in chromatographic analysis is introduced and calculated to be 0.61, indicating that these two additives can be detected simultaneously. Our research provides a new solution for detecting additives in infant formula.
Nanomaterials for Potential Uses in Extraterrestrial Environments
Authors: Nicosia Angelo , Mineo Placido
Published: May 2024

Over the past decades, the development of nanomaterials has played an important role in the most intriguing aspects of new technologies in several scientific fields, such as nanoelectronics, nanomedicine [...]
Development of Biologically Active Phytosynthesized Silver Nanoparticles Using Marrubium vulgare L. Extracts: Applications and Cytotoxicity Studies
Authors: Lupuliasa Alina Ioana , Prisada Răzvan Mihai , Matei (Brazdis) Roxana Ioana , Avramescu Sorin Marius , Vasile Bogdan Ștefan , Fierascu Radu Claudiu , Fierascu Irina , Voicu-Bălașea Bianca , Meleșcanu Imre Marina , Pițuru Silviu-Mirel , Anuța Valentina , Dinu-Pîrvu Cristina Elena
Published: May 2024

Metal nanoparticle phytosynthesis has become, in recent decades, one of the most promising alternatives for the development of nanomaterials using “green chemistry” methods. The present work describes, for the first time in the literature, the phytosynthesis of silver nanoparticles (AgNPs) using extracts obtained by two methods using the aerial parts of Marrubium vulgare L. The extracts (obtained by classical temperature extraction and microwave-assisted extraction) were characterized in terms of total phenolics content and by HPLC analysis, while the phytosynthesis process was confirmed using X-ray diffraction and transmission electron microscopy, the results suggesting that the classical method led to the obtaining of smaller-dimension AgNPs (average diameter under 15 nm by TEM). In terms of biological properties, the study confirmed that AgNPs as well as the M. vulgare crude extracts reduced the viability of human gingival fibroblasts in a concentration- and time-dependent manner, with microwave-assisted extracts having the more pronounced effects. Additionally, the study unveiled that AgNPs transiently increased nitric oxide levels which then decreased over time, thus offering valuable insights into their potential therapeutic use and safety profile.
Rational Construction of Pt Incorporated Co3O4 as High-Performance Electrocatalyst for Hydrogen Evolution Reaction
Authors: Wang Peijia , Yan Yaotian , Qin Bin , Zheng Xiaohang , Cai Wei , Qi Junlei
Published: May 2024

Electrocatalysts in alkaline electrocatalytic water splitting are required to efficiently produce hydrogen while posing a challenge to show excellent performances. Herein, we have successfully synthesized platinum nanoparticles incorporated in a Co3O4 nanostructure (denoted as Pt-Co3O4) that show superior HER activity and stability in alkaline solutions (the overpotentials of 37 mV to reach 10 mA cm−2). The outstanding electrocatalytic activity originates from synergistic effects between Pt and Co3O4 and increased electron conduction. Theoretical calculations show a significant decrease in the ΔGH* of Co active sites and a remarkable increase in electron transport. Our work puts forward a special and simple synthesized way of adjusting the H* adsorption energy of an inert site for application in HER.
Association of Knowledge and Health Habits with Physiological Hydration Status
Authors: McDermott Brendon P. , Zhao Xiujing , Veilleux Jennifer C.
Published: May 2024

The association of hydration knowledge and health habits with hydration status and fluid intake is rarely examined. We sought to determine whether knowledge or physical health behaviors predict physiological hydration status and fluid intake. Ninety-six participants (59 female; 27 ± 10 year) completed the previously validated hydration survey. Participants then recorded total fluids consumed (TFC), collected urine, and tracked void frequency for 24 h. Hydration status was assessed via 24 h urine specific gravity (USG) and osmolality (Uosm). Health behaviors included self-reported physical activity, BMI, smoking, alcoholic drinking, and sleep status. TFC was significantly correlated with 24 h USG (r = −0.390; p < 0.001), Uosm (r = −0.486; p < 0.001), total urine volume (r = 0.675; p < 0.001), and void frequency (r = 0.518; p < 0.001). Hydration knowledge was not correlated with 24 h USG (r = 0.085; p = 0.420), Uosm (r = 0.087; p = 0.419), urine total volume (r = 0.019; p = 0.857), void frequency (r = 0.030; p = 0.771), or TFC (r = 0.027; p = 0.813). Hydration knowledge did not predict 24 h USG (LR+ = 1.10; LR− = 0.90), Uosm (LR+ = 0.81; LR− = 1.35), or TFC (LR+ = 1.00; LR− = 1.00). Health habits did not predict 24 h USG, Uosm, or TFC. In conclusion, self-reported 24 h diet and fluid log recording is comparable to hydration status verification via 24 h urine collection. Hydration knowledge and health habits are not related to, or predictive of, hydration status.
Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis
Authors: Ravnikar Matjaž , Štrukelj Borut , Otašević Biljana , Sirše Mateja
Published: May 2024

The present study screened various fungal species for inhibitors of alpha-glucosidase, alpha-amylase, and DPP-4, enzymes that are crucial in carbohydrate metabolism. Ethanolic extracts exhibited superior inhibitory activity compared to water extracts, suggesting their potential as sources of anti-diabetic agents. Further fractionation revealed fomentariol from Fomes fomentarius as a potent inhibitor of alpha-glucosidase and DPP-4, with higher activity against alpha-glucosidase than acarbose. Fomentariol presents a novel avenue for diabetes management, demonstrating the simultaneous inhibition of key enzymes in glucose metabolism. However, comprehensive clinical studies are needed to evaluate its safety and efficacy in humans.
Profibrotic Inflammatory Cytokines and Growth Factors Are Predicted as the Key Targets of Uncaria gambir (Hunter) Roxb. in Keloids: An Epistatic and Molecular Simulation Approach
Authors: Ningsih Sri Suciati , Fadilah Fadilah , Jusman Sri Widia A. , Syaidah Rahimi , Yashiro Takashi
Published: May 2024

Keloid is characterized as the fibrotic tissue resulting from the increase of fibroblast activity. Uncaria gambir (Hunter) Roxb. possesses bioactive compounds that have potential as antifibrotic agents, while the mechanism of action in keloid has not yet been elucidated. The aim of this study was to investigate the interaction of gambir bioactive compounds with keloid target proteins using an epistatic and molecular simulation approach. The known bioactive compounds of gambir targets and keloid-related protein targets were screened using databases. The network was constructed and analyzed to obtain the core protein targets. The targets were enriched to describe the Gene Ontology (GO) and pathway related to the proteins. Eleven targets were defined as the main targets of gambir bioactive compounds related to keloid disease. Gambiriin C, Isogambirine, and Procyanidin B1 were identified as the most promising compounds with the highest binding energy to transforming growth factor beta 1 (TGFβ1), AKT serine/threonine kinase 1 (AKT1), and matrix metallopeptidase 1 (MMP1) as the target proteins. GO enrichment and pathway analysis found that gambir bioactive compounds may act on keloid-related target proteins to regulate cell proliferation, migration, transcription, and signal transduction activity via profibrotic cytokine and growth factor signaling pathways. This study provides a reference for potential targets, compounds, and pathways to explain the mechanism of gambir against keloid.
Correction: Zaman et al. Synthesis and Evaluation of Thiol-Conjugated Poloxamer and Its Pharmaceutical Applications. Pharmaceutics 2021, 13, 693
Authors: Zaman Muhammad , Saeed Sadaf , Imtiaz Bajwa Rabia , Shafeeq Ur Rahman Muhammad , Rahman Saeed , Jamshaid Muhammad , Rasool Muhammad , Majeed Abdul , Imran Imran , Alqahtani Faleh , Alshehri Sultan , AlAsmari Abdullah , Ali Nemat , Alasmari Mohammed
Published: May 2024

In the original publication, there was a mistake in one author name, Mohammed Alasmari should be Mohammed S [...]