bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Kewajiban Ingkar Notaris dalam Pelaksanaan Tugas Jabatan Berdasarkan UUJN
Authors: Fadha Kusumandari Ganis Noer
Published: January 2024

This research is inspired by a problem when notaries are in a condition to be testiffier in the judicial process, but on the other hand, notaries have to maintain confidentiality which is part of carrying out their oath of office. This research is normative research using statutory and conceptual approaches and then analyzed using qualitative descriptive methods. The formulation of the problem raised is first, whether notaries must always carry out their obligations to deny the UUJN, and second, whether there is a difference between the obligations of a notary and the rights of a notary based on the UUJN. The results of this research show that notaries must always carry out their obligations to deny. Because the Notary's obligation to deny is an obligation and obligation for the notary in connection with his duties and position as long as the law does not determine otherwise. Then, there is a difference between the obligation to deny and the right to deny. The difference lies in the legal basis that regulates, namely Article 4 paragraph (2), Article 16 paragraph (1) letter f, and Article 54 UUJN. The implementation of the obligation to renege does not require approval from anyone because it is guaranteed by law, whereas the Right to renounce is regulated in Article 1365 of the Civil Code, Article 1909 of the Civil Code, Article 146 HIR, Article 174 RGB, Article 170 of the Criminal Procedure Code, Article 322 of the Criminal Code. Most of the implementation of the right of recusal in these arrangements requires approval from the judge in the court handling the case.
Akibat Hukum Side Streaming yang Dilakukan Nasabah pada Akad Pembiayaan Musyarakah
Authors: Damayanti Lingga
Published: January 2024

This research examines the legal consequences of side streaming carried out by customers in musyarakah financing contracts, with a problem formulation, namely what legal consequences arise if side streaming occurs by customers. This research is normative juridical research using a statutory approach. The results of the research conclude that the legal consequences of side streaming or misappropriation of financing funds carried out by customers using funds that are not in accordance with the contract and/or the initial purpose of the financing is fasakh, namely the cancellation of a contract due to reasons that result in disruption of the value of the contract due to breach of contract and giving rise to financing problems. Side streaming is included in errors or mistakes (ghalat). The musyarakah financing agreement was canceled because the customer used the financing funds not in accordance with the contents of the contract.
Analisis Terhadap Implikasi Perseroan Terbatas Yang Didirikan Melalui Biro Jasa Hukum
Authors: Almira Kun Salma
Published: January 2024

A notary has the duties and authority to make a deed of establishment of a limited liability company. However, in reality, it was found that Notaries did not sign the deed of establishment simultaneously in front of the presenters. The formulation of the problem in this research is first, what are the implications of a Limited Liability Company established through a Legal Services Bureau without being signed by a Notary at the same time? Second, what is the Notary's responsibility regarding the deed of establishment of a Limited Liability Company which was established through the Legal Services Bureau without being signed by a Notary at the same time? This research is normative legal research carried out using a statutory approach and a conceptual approach. The results of the research and discussion show that the implication that occurs is that the deed of establishment of a limited liability company is degraded into a private deed. Apart from that, according to the principle of responsibility based on mistakes, notaries can be held responsible if they are proven guilty. The responsibility referred to is in the form of reimbursement of costs, compensation, and interest. This is regulated in Article 44 of Law Number 2 of 2014 on Amendments to Law Number 30 of 2004 on the Position of Notaries.
Peran Kewenangan Dan Tanggungjawab Notaris Dalam Melakukan Pengurusan Perizinan Berusaha Berbasis Risiko Melalui Online Singel Submission
Authors: Amanda M. Reksa
Published: January 2024

Risk-based business licensing is licensing administered by OSS institutions, where business actors to obtain permits must go through the OSS platform, in practice there is a notary who handles business licensing. So this research discusses first, what is the role and authority of a notary in arranging business permits through OSS? Second, is the notary responsible for arranging business permits by a notary through OSS which causes losses to business actors? The type of research used is normative legal research using conceptual and statutory approaches. The results of this research conclude firstly that the authority of a notary as a public official is to make authentic deeds for all deeds, agreements, and decrees as intended in Article 15 of the Law on the Position of Notaries. Meanwhile, the authority of notaries in arranging risk-based business permits through OSS must be based on the granting of power of attorney. Second, the notary's responsibility in arranging business permits through OSS to business actors who experience losses must be proven beforehand. If the loss in processing business permits is caused by a deed made, the notary must be held accountable for carrying out his duties in terms of making authentic deeds if he violates the provisions as intended in UUJN. However, if the sanctions imposed result in losses due to the implementation of business licensing, the notary cannot be held responsible.
A Proof of the Riemann Hypothesis Based on a New Expression of the Completed Zeta Function
Authors: Zhang Weicun
Published: January 2024

The celebrated Riemann Hypothesis (RH) is proved based on a new absolute convergent expression of $\xi(s)$, which was obtained from the Hadamard product, through paring $\rho_i$ and $\bar{\rho}_i$, and putting all the multiple zeros together in one factor, i.e. $$\xi(s)=\xi(0)\prod_{\rho}(1-\frac{s}{\rho})=\xi(0)\prod_{i=1}^{\infty}\Big{(}\frac{\beta_i^2}{\alpha_i^2+\beta_i^2}+\frac{(s-\alpha_i)^2}{\alpha_i^2+\beta_i^2}\Big{)}^{d_{i}}$$ where $\xi(0)=\frac{1}{2}$, $\rho_i=\alpha_i+j\beta_i$ and $\bar{\rho}_i=\alpha_i-j\beta_i$ are the complex conjugate zeros of $\xi(s)$, $0<\alpha_i<1$ and $\beta_i\neq 0$ are real numbers, $d_i\geq 1$ is the real (unique and unchangeable) multiplicity of $\rho_i$, $\beta_i$ are arranged in order of increasing $|\beta_i|$, i.e., $|\beta_1|\leq|\beta_2|\leq|\beta_3|\leq \cdots$, $i =1,2,3, \cdots, \infty$. Then, according to the functional equation $\xi(s)=\xi(1-s)$, we have $$\prod_{i=1}^{\infty}\Big{(}1+\frac{(s-\alpha_i)^2}{\beta_i^2}\Big{)}^{d_{i}}=\prod_{i=1}^{\infty}\Big{(}1+\frac{(1-s-\alpha_i)^2}{\beta_i^2}\Big{)}^{d_{i}}$$ which, owing to the uniqueness and unchangeableness of $d_i$ (see Lemma 3 for the proof details), is finally equivalent to $$\begin{cases}&\alpha_i=\frac{1}{2}\\ & |\beta_1|<|\beta_2|<|\beta_3|<\cdots\\&i =1,2,3, \cdots, \infty \end{cases}$$ Thus, we conclude that the RH is true.
Endogenous Neuromodulation at Infra-Low Frequency:
Method and Theory
Authors: Othmer Siegfried , Othmer Susan FitzGerald
Published: January 2024

Clinical work conducted over the last seventeen years at the EEG Institute in Los Angeles and by other neurofeedback providers around the world has demonstrated the utility of extending frequency-based neurofeedback deep into the infra-low frequency (ILF) region, using the method of endogenous neuromodulation described herein. The method is characterized by the absence of any overt reinforcements, which makes it possible to extend the clinical reach to extremely low frequencies. As the training frequency is lowered, the signal becomes more difficult to discriminate, and ultimately it can only be discerned by the brain itself, in the process of endogenous neuromodulation. The method emulates how the brain does skill learning in general: It must observe itself performing the skill, with feedback on its performance.
While the immediate target of ILF neurofeedback is enhanced self-regulatory competence--with symptomatic relief and functional recovery the secondary consequences, progressive lowering of the target frequencies has led to improved outcomes in application to challenging dysfunctions such as episodic suicidality, migraine, seizures, and bipolar mood swings. The work has also yielded insights into how the frequency domain is organized. The training proceeds best at frequencies that are specific to each individual, and these are referred to as optimal response frequencies (ORFs).
These frequencies differ for various placements but stand in two fixed relationships to one another, one that holds over the EEG spectral range, and another that holds over the entire ILF range. Training in the ILF region engages the dynamics of the glial-neuronal networks, which govern tonic, resting state regulation. The collective clinical experience with ILF neuromodulation within a large practitioner network supports the case for making protocol-based, individualized ‘homeodynamic’ regulation a therapeutic priority, particularly for our most impacted clinical populations: addiction, trauma formations, traumatic brain injury, and the dementias. The case is made for further outcome studies and foundational research.
Inverse Problem to Control the Coefficient of a Differential Equation in Time
Authors: TERNOVSKI VLADIMIR , ILYUTKO VICTOR
Published: January 2024

There are many problems based on solving non-autonomous differential equations of the form x¨(t)+ω2(t)x(t)=0, where x(t) represents the coordinate of a material point and ω is the angular frequency. The inverse problem involves finding the bounded coefficient ω. Continuity of the function ω(t) is not required. The trajectory x(t) is unknown, but the initial and final values of the phase variables are given. The variation principle of minimum time for the entire dynamic process allows for the determination of the optimal solution {x(t),ω(t)}. Thus, the inverse problem is an optimal control problem. No simplifying assumptions were made.
Collatz Conjecture
Authors: Durmagambetov Asset , Durmagambetova Aniyar
Published: January 2024

This paper presents an analysis of the number of zeros in the binary representation of natural numbers. The primary method of analysis involves the use of the concept of the fractional part of a number, which naturally emerges in the determination of binary representation. This idea is grounded in the fundamental property of the Riemann zeta function, constructed using the fractional part of a number. Understanding that the ratio between the fractional and integer parts of a number, analogous to the Riemann zeta function, reflects the profound laws of numbers becomes the key insight of this work. The findings suggest a new perspective on the interrelation between elementary properties of numbers and more complex mathematical concepts, potentially opening new directions in number theory and analysis."
Global Symmetry of Quantum Systems Involving Space
Authors: Li Yuanxin
Published: January 2024

In this paper, we consider particles together with the surrounding space as an indivisible system, and then investigate the maximum symmetry of the system at the quantum level. We introduce a new quantity to describe the evolution of this system before and after measurement. The effective mass of gravity is estimated. We also show that a free quantum particle as the source of energy and momentum do not produce gravity.
Cavity Swelling of 15-15Ti Steel at High Doses by Ion Irradiation
Authors: Liu Cong , Ma Hailiang , Fan Ping , Li Ke , Li Xinxin , Qian Qiuyu , Zhong Hao , Li Jian , Ma Siyuan , Shan Ziyang , Zhang Qiaoli , Wen Ali , Du Ai-Bing , Ren Yuanyuan , Li Junhong , Su Xiping , Feng Wei , Zhu Shengyun , Yuan Daqing
Published: January 2024

The swelling behavior of titanium-modified austenitic stainless steel 15-15Ti was investigated by pre-implantation of He at room temperature followed by Ni irradiation at 580 °C to peak doses of 120, 240 and 400 dpa. Relatively smaller cavities were observed in the zone of helium implantation while large cavities appeared in the region near the damage peak. A correction formula of the dpa curve was proposed and applied for samples with large swelling. It is found that the steady-state swelling rate of 15-15Ti keeps at ~1% /dpa even to high doses. By comparing the swelling data of the helium-implanted and helium-free regions at same doses, 70 dpa and 122 dpa, the suppression of excessive helium on swelling can be deduced at such doses.
Pulsed Electromagnetic Field Stimulation in Bone Healing and Joint Preservation: A Narrative Review of the Literature.
Authors: Caruso Gaetano , Massari Leo , Lentini Sebastiano , Setti Stefania , Gambuti Edoardo , Saracco Achille
Published: January 2024

Background: biophysical stimulation therapy, and in particular Pulsed Electromagnetic Fields (PEMFs) and capacitively coupled electric fields (CCEFs) has significantly increased in the last twenty years. For this, it is necessary to have clear information regarding the efficacy, the therapeutic indication and the expected objectives. Methods: we conducted a narrative review taking into consideration different types of studies with different areas of application. The objective was to take into consideration and analyze the different fields of use and the relevant information present in the literature. Results: There is unanimous opinion regarding the usefulness of applying biophysical therapy on the bone compartment both in terms of the tissue healing process and the symptoms associated with this situation. Differently, but no less importantly, in the joint compartment positive opinions were observed mainly on the inflammatory and catabolic process, however, at present,we did not report evidence regarding cartilaginous tissue regeneration. Conclusion: the effectiveness of PEMFs and CCEFs on the bone healing process in the Orthopedic and Traumatology fields is consolidated evidence in the literature. We have also found positive results on symptoms and patient compliance with rehabilitation therapies. Therefore, notable application can be envisaged in the fields of Prosthetic Surgery and Sports Medicine.
Intrusion Detection System for Big Data Environment Using Deep Learning
Authors: Potnurwar Pooja
Published: January 2024

The necessity for effective intrusion detection systems (IDS) in big data environments has grown critical due to the rising prevalence of big data systems and the rising amount of security threats. Applying conventional intrusion detection methods to the enormous and intricate data produced by big data ecosystems presents difficulties. Deep learning, has proven to be exceptionally adept at deciphering complex, large-scale data. This study proposes a Deep Learning-based Intrusion Detection System (IDS) created specifically for the Big Data environment. Traditional intrusion detection systems struggle to efficiently identify and prevent cyber threats due to the ever-increasing volume and complexity of data in current networks. We suggest an IDS that makes use of Deep Learning (CNN, LSTM, GAN, etc.), to address this problem. These cutting-edge neural network topologies give the system the ability to process and analyze massive amounts of data for precise intrusion detection. Data collection, data preprocessing, feature engineering, DL model training, intrusion detection, warning generation, and reaction are some of the crucial parts of the suggested IDS. The data collection module mines the Big Data environment for network traffic, system logs, and security event information. To make sure the data is suitable for analysis, it is preprocessed. To improve the detection abilities of the DL models, important features are extracted from the data using feature engineering approaches.
Isolation and Identification of Feather-Degrading Bacteria and Cloning of Their Keratinase Gene
Authors: Ma Chengying , Feng Yingying , Chen Bingrui , Meng Zhichao , Zhang Yinghao , Meng Dongheng , Fan Yonghong
Published: January 2024

Abstract: There are a large number of cross-linked chemical bonds such as tight disulfide bonds, hydrogen bonds,and salt bonds in keratin, which makes it difficult to break the structural stability of the protein using conventional methods. The degradation of feather waste using keratinases produced by microorganisms has the advantage of being efficient and environmentally friendly. In this study, 23 strains capable of producing transparent circles were obtained via preliminary screening with skim milk as the sole carbon and nitrogen source, and 9 strains capable of degrading feathers were obtained via rescreening with feathers as the sole carbon and nitrogen source. Finally, through the determination of enzyme activity, the strain CY-A with a high ability to degrade feathers was obtained. The strain was identified as Bacillus tequilensis via morphological observation, physiological and biochemical identification, and 16 S rRNA molecular biology. The keratinase gene (bta) of Bacillus tequila was cloned, and its full-length gene sequence was 1110 bp, containing an open reading frame of 1089, encoding 369 amino acids (GeneBank accession number OR733336). The physicochemical properties, secondary structure, and tertiary structure of the recombinant protein were analyzed using bioinformatics tools such as ProtParm, SOPMA, MEGA, and SWISS-MODELS. It was found that the relative molecular mass was 37.953 kD and that the isoelectric point was 8.48. The protein was a hydrophilic protein. The keratinase bta gene was ligated to the expression vector pET28a(+) using T4 ligase, and the recombination expression plasmid pET28-bta was constructed and transformed into E. coli BL21(DE3) to obtain recombinant engineered bacteria. The expressed keratinase was purified using a Ni2+ affinity chromatography column to obtain recombinant bta keratinase bta with a molecular weight of 37.953 kD. The identification and characterization of this keratinase gene provides some theoretical basis for the further enhancement of keratinase activity by means of genetic engineering.
OsLRR-RLP2 Gene Regulates Immunity to Magnaporthe oryzae in Japonica Rice
Authors: Kim Hyo-Jeong , Jang Jeong Woo , Pham Thuy , Nguyen Van N.T. , Kim Ji-Hyun , Park Chan woo , Gho Yun-Shil , Kim Eui-Jung , Kwon Soon-Wook , Jeon Jong-Seong , Kim Sun Tae , Jung Ki Hong , Kim Yu-Jin
Published: January 2024

Rice is an important cereal crop worldwide, the growth of which is affected by rice blast disease, caused by the fungal pathogen Magnaporthe oryzae. As climate change increases the diversity of pathogens, the disease-resistance genes (R genes) in plants must be identified. The major blast-resistance genes have been identified in indica rice varieties; therefore, japonica rice varieties with R genes now need to be identified. Because leucine-rich repeat (LRR) domain proteins possess R-gene properties, we used bioinformatics analysis to identify the rice candidate LRR domain receptor-like proteins (OsLRR-RLPs). OsLRR-RLP2, which contains six LRR domains, showed differences in the DNA sequence, containing 43 single-nucleotide polymorphisms (SNPs) in indica and japonica subpopulations. The results of M. oryzae inoculation analysis indicated that indica varieties with partial deletion of OsLRR-RLP2 showed susceptibility, whereas japonica varieties with intact OsLRR-RLP2 showed resistance. oslrr-rlp2 mutant generated using clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) showed increased pathogen susceptibility, whereas plants overexpressing this gene showed pathogen resistance. These results indicate that OsLRR-RLP2 confers resistance to rice, and OsLRR-RLP2 may be useful for breeding resistant cultivars.
RNA N6-Methyladenosine Modification in DNA Damage Response and Cancer Radiotherapy
Authors: Wang Cui , Yao Shibo , Zhang Tinghui , Sun Xiaoya , Bai Chenjun , Zhou Ping-Kun
Published: January 2024

N6-methyladenosine (M6A) modification is the most abundant internal chemical modification on RNA molecules in eukaryotes and can affect mRNA metabolism and regulate RNA transcription, nuclear export, splicing, degradation, translation, ets, and has a significant impact on various aspects of physiology or pathobiology. Radiotherapy is the most common measure of tumor treatment, variety of cellular intrinsic mechanisms affect the responses of cells to ionizing radiation (IR) and effectiveness of cancer radiotherapy. In this review, we summarize and discuss the recent advances about the roles and mechanisms of RNA M6A methylation in cellular responses to radiation-induced DNA damage response, and outcomes of cancer radiotherapy. Insights into the RNA M6A methylation in radiation biology may facilitate the improvement of therapeutic strategies for cancer radiotherapy as well as radioprotection on normal tissues.
Extended Guided Filter: Simultaneous Noise Suppression and Details Enhancement
Authors: Li Jian , Sun Zhenping
Published: January 2024

Guided image filter implicitly balances noise and details based on local variance, achieving noise suppression while preserving prominent edges. However, we have observed limitations in using variance to distinguish between noise and image details, resulting in the suppression of fine structures alongside noise. Furthermore, the goal of enhancing image details, which is crucial in image filtering, has not been adequately addressed in edge-preserving filter design. In this paper, we approach image filtering as a problem of spectral energy reconfiguration, where the gain of each spectral band is adaptively regulated to achieve simultaneous noise suppression and detail enhancement. Instead of relying on variance, we employ a linear noise estimator to obtain the Signal-to-Noise Ratio (SNR) measurement necessary for dynamic gain regulation. Similar to the guided image filter, we determine the filter coefficients by solving the closed-form solution of the optimizer. We demonstrate that the proposed extended guided filter effectively integrates information from multiple spectral bands locally, allowing for the joint enhancement of meaningful details while simultaneously smoothing noise.
Implementation of a Partial Order Data Security Model for the Internet of Things (IoT) Using Software Defined Networking (SDN)
Authors: Stambouli Abdelouadoud , Logrippo Luigi
Published: January 2024

Data security in the Internet of things (IoT) is often implemented by means of encryption, which can be burdensome for some entities. We propose in this paper a solution based on routing, by which data are forwarded only to entities that are intended to receive them. An IoT network can be seen as a partial order of equivalence classes of entities, and each entity can be labeled according to the position of its equivalence class in the partial order. The partial order can be constructed according to requirements of secrecy (or confidentiality), integrity and conflicts. Routing tables among entities can be compiled by using the labels. The method is demonstrated in this paper for Software defined networking (SDN) routers and controllers. We propose a centralized IoT architecture with a cloud structure using SDN as networking infrastructure, where storage entities (i.e. cloud servers) are associated with application entities. A small ‘hospital’ example is shown for illustration. Procedures for network reconfigurations are discussed. We also demonstrate the method for the normal case where different partial orders coexist among a set of entities. The method proposed does not impose an overhead on the normal functioning of an SDN network, since it requires calculations only when the network must be reconfigured, because of administrative intervention or policies.
Optimal Mesh Pore-Size Combined with a Periodic Air Mass Load for the Fouling Control in Self-Forming Dynamic Membrane BioReactor (SFD MBR) for a Sustainable Treatment of a Real Municipal Wastewater
Authors: Boulerial Senouci , Salerno Carlo , Castrogiovanni Fabiano , Tumolo Marina , Berardi Giovanni , Debab Abdelkader , Haddou Boumediene , Benhamou Abdellah , Pollice Alfieri
Published: January 2024

The Self-Forming Dynamic Membrane BioReactor (SFD MBR) is a cost-effective alternative to conventional MBR, where the synthetic membrane is replaced by the “cake layer”, an accumulation of the biological suspension over a surface of inert low-cost support, caused by a suction force. Under optimized conditions, the cake layer reveals easy to remove and quick to form again, resulting a “dynamic membrane”. The permeate of SFD MBR has chemo-physical characteristics comparable to those of conventional MBR. In this paper, two nylon meshes with a pore-size of 20 and 50 µm respectively were tested in a bench scale SFD MBR where a periodic air mass load (AML) was supplied tangential to the filtration surface to maintain filtration effectiveness. The SFD MBR equipped with the 20 µm nylon mesh coupled to 5 min of AML every 4 hours showed the best performance both ensuring a permeate with turbidity values always below 3 NTU and revealing no critical fouling. A benchmark test, conducted in the same experimental time, with identical operating conditions, and the only difference of a suction break (relaxation) instead of the AML. This latter test produced a permeate of very good quality, but it needed frequent mesh cleanings, showing that a periodic AML coupled with the use of a 20 µm mesh can be a good strategy for long term operation of SFD MBR.
Clinical Efficacy of Sitafloxacin-Colistin-Meropenem and Colistin-Meropenem among Carbapenem-Resistant and Multidrug-Resistant Acinetobacter baumannii Hospital-Acquired Pneumonia (Hap) / Ventilator-Associated Pneumonia (Vap) Patients in One Super-ter
Authors: Wantanatavatod Manasawee , Wongkulab Panuwat
Published: January 2024

Background: Carbapenem-resistant A. baumannii (CRAB) hospital-acquired pneumonia (HAP)/ventilator-associated pneumonia (VAP) is becoming a globally therapeutic problem. Method: The open-label, randomized, superiority, single-blind trial was conducted in Rajavithi Hospital, a super-tertiary care in Bangkok, Thailand. We included CRAB HAP/VAP patients randomly assigned to receive sitafloxacin-colistin-meropenem compared to colistin-meropenem to assess mortality, clinical response, and adverse effects. Result: April 2021-2022, 77 patients were randomized and received combination treatment sitafloxacin-colistin-meropenem (n = 40) or colistin-meropenem (n = 37). Among two groups, the all-cause mortality rate was no significant difference at 7-days and 14-days (7.5% vs 2.7%; p = 0.616 and 10% vs 10%; p = 1, respectively). Patients received sitafloxacin-colistin-meropenem showed improved clinical response, compared patients receiving colistin-meropenem with both intentions to treat (87.5% vs 62.2%; p = 0.016) and per-protocol analysis (87.2% vs 67.7%; p = 0.049). The adverse effects were not different among 2 groups. Conclusion: Adding sitafloxacin as third agent in meropenem plus colistin could improve clinical in CRAB HAP/VAP with comparable adverse effects. Sitafloxacin-meropenem-colistin could be another option for combatting CRAB HAP/VAP
The Cow Gutbiome CY Study: Investigating the Composition of the Cattle Gut microBIOME in Health and Infectious Disease Transmission in CYprus
Authors: Mavrides Daphne E , Liapi Maria , Ierodiakonou Despo , Pipis Christodoulos , Malas Stavros , Gentekaki Eleni , Tsaousis Anastasios D.
Published: January 2024

Recent evidence suggests that the lower gut microbiome of ruminants presents roles in their health and environment, including the development of the mucosal immune system, milk production efficiency and quality and subsequent methane emissions. However, there are proportionately fewer studies on this complex microbial community in cattle and region-focus studies are non- existent. Herein, we present the research protocol of the GUTBIOME CY project pertaining to determine the composition of the lower gut microbiome in dairy cows situated in 37 farms across five districts of the island of Cyprus. Detailed questionnaires on animal husbandry and farming practices will be gathered from each farm. Faecal, milk (individual and bulk) and water samples will also be collected from cows and their offspring. Samples will be analysed using a combination of molecular biology and bioinformatics pipelines to define microbiome profiles and antimicrobial resistance (AMR). Information collected from the questionnaires will be use to test for associations between animal husbandry or farming practices and microbiome components and AMR. Collected samples will establish the first dairy cattle biobank in the country for contributing substantially towards scientific advancements in microbiome research and providing insights to all stakeholders, tailored to the unique agricultural context of Cyprus.
Echocardiographic Findings and Subsequent Risk of Native Valve Endocarditis
Authors: Quintero-Martinez Juan Andres , Hindy Joya-RIta , Villarraga Hector R , Lahr Brian D , Dayer Mark J , Thornhill Martin H , O'Horo John C , Michelena Hector I , Anavekar Nandan S , Sendi Parham , DeSimone Daniel C , Baddour Larry M
Published: January 2024

Background: The association of echocardiographic findings and subsequent risk of left-sided native valve endocarditis (LS-NVE) is undefined. The aim of this study was to determine if transthoracic echocardiographic (TTE) measurements are associated with the subsequent development of LS-NVE in patients without cardiac predisposing conditions.

Methods: Institutional databases were evaluated for adults diagnosed with LS-NVE from 2008 to 2020. Patients with prosthetic valves, cardiovascular implantable electronic devices, intracardiac devices, injection drug use, and predisposing cardiac conditions were excluded. Only patients who had a TTE performed 6 months to 3 years before the development of LS-NVE were included as cases. Controls were patients within the same Mayo location with a TTE report and were matched in a 1:3 ratio according to age, gender, Charlson Comorbidity Index, and echocardiography date.

Results: There were 148 cases and 431 matched controls. As compared to controls, IE cases had a higher prevalence of diabetes mellitus (46.6% vs. 30.4%) and chronic kidney disease (46.6% vs. 28.1%) (p<0.001). Left ventricular outflow tract velocity (p=0.017), left ventricular ejection fraction (p=0.018), and E: e’ ratio (p=0.050) were associated with LS-NVE.

Conclusions: Echocardiographic measurements were associated with subsequent LS-NVE development in this pilot study. A larger cohort of LS-NVE patients, however, is needed to validate these findings.
Finding Inner Peace, Forging Inner Strength with GABA: the Intertwined Dance of Mental Relaxation and the Immune System
Authors: Ruggiero Marco
Published: January 2024

This article describes a novel topical composition constituted by gamma-amino butyric acid (GABA) and microbial chondroitin sulfate. This composition exhibits potential for non-invasive intervention in anxiety management, sleep quality enhancement, and promotion of brain-related functions like meditation and nonlocal consciousness. The core component comprises GABA, a key inhibitory neurotransmitter within the central nervous system, complexed with a suitable carrier molecule, microbial chondroitin sulfate. This complexation aims to enhance transdermal absorption and optimize delivery of GABA to target tissues. The proposed mechanism of action involves modulation of GABAergic signal transduction pathways. Application of the topical composition allows GABA penetration into the skin and potentially deeper tissues, where it interacts with GABA receptors. This interaction leads to mental calmness and relaxation as assessed by electroencephalography. The influence of GABAergic signaling on brain circuits demonstrated in this article, when associated with meditation and nonlocal consciousness, suggests potential for the composition to support these practices. The advantage of such an approach consists in avoiding the potential systemic side effects associated with oral or injectable administration of GABA, anxiolytics or hypnotics. Furthermore, the combination of GABA and microbial chondroitin sulfate may offer synergistic benefits, potentially enhancing the overall biological effects. In conclusion, this article presents a novel topical approach for managing anxiety, enhancing sleep quality, and potentially facilitating meditation and nonlocal consciousness through modulation of GABAergic signaling pathways. While further research is necessary, the potential for a non-invasive and potentially side-effect-free intervention in these areas is promising.
The Interplay of Neurotransmitters and Calcium Dynamics in Retinal Synapses During Development, Health, and Disease
Authors: Boff Johane M. , Shrestha Abhishek P , Madireddy Saivikram , Viswaprakash Nilmini , Santina Luca Della , Vaithianathan Thirumalini
Published: January 2024

The intricate functionality of the vertebrate retina relies on the interplay between neurotransmitter activity and calcium dynamics, offering important insights into de-velopmental processes, physiological functioning, and disease progression. Neuro-transmitters orchestrate cellular processes to shape the behavior of the retina under diverse circumstances. Despite research to elucidate the roles of individual neuro-transmitters in the visual system, there remains a gap in our understanding of the holistic integration of their interplay with calcium dynamics in the broader context of neuronal development, health, and disease. To address this gap, the present review explores the mechanisms used by the neurotransmitters glutamate, GABA, glycine, dopamine, and acetylcholine and their interplay with calcium dynamics. This con-ceptual outline is intended to inform and guide future research, underpinning novel therapeutic avenues for retinal-associated disorders.
A New Seafood Import Policy for Nations to Combat Illegal Fishing
Authors: Roberson Leslie , Hosch Gilles , Wilcox Chris , Dominguez Martinez Rosa Mar , Sant Glenn , Klein Carissa
Published: January 2024

Seafood is the world’s most globally traded food commodity but lacks regulation to mitigate illegal, unreported, and unregulated fishing
Bioengineered Platforms for Detection Of Group-1 Carcinogenic Metals
Authors: Singh Akanksha
Published: January 2024

Studies at the molecular, systemic, and epidemiological levels have shown that chronic metal exposure is linked to significant health consequences, including cancer, affecting hundreds of millions worldwide. Subtle and convoluted mechanisms underline metals' toxicity and carcinogenicity. The use of sensors for carcinogenic metals' trace detection is on the rise due to their selectivity, simplicity, and affordability. Biotechnology and microelectronics in the development of sensors have grown complementarily in recent years. This study offers a comprehensive overview of current research and advancements in developing sensors for detecting carcinogenic metals. Here, we have focussed on the developed biosensor platforms for group 1 carcinogens, i.e., arsenic, nickel, cadmium, chromium, and beryllium, along with their brief roles in human carcinogenesis. This review also looks at the importance of sensing such metal exposure in humans from a larger perspective, hoping to influence future research toward early prevention and treatment of illnesses like cancer.
Analysis of a Cohort of Patients with Atrial Fibrillation on Warfarin: The Jordan Atrial Fibrillation Study (JoFib)
Authors: Al-Shatanawi Tariq N. , Alkouri Osama , ALSalamat Husam A. , Al-Zubiedi Sameh , Qaladi Omar Aawadh , Dabbour Rasha , Al-Bashaireh Ahmad , Hweidi Aysam I. , Al-Hadid Lourance A. , Hammoudeh Ayman
Published: January 2024

(1) Background: Most patients with atrial fibrillation, on warfarin therapy, are at higher risk of morbidity and mortality. However, data targeting patients with atrial fibrillation, who take warfarin therapy, are limited in Jordan. This study aimed to provide in-depth analysis of a cohort of patients with atrial fibrillation on warfarin regarding patients’ characteristics, atrial fibrillation related symptoms, interventions, comorbidities, and 12-months outcomes. (2) Methods: The study enrolled 645 patients with atrial fibrillation, on warfarin, from 28 health settings across Jordan. Standardized clinical data form was utilized to collect data upon enrollment, at one, six, and 12 months post initial assessment. Descriptive statistics were used for the description of variables. (3) Results: The most commonly reported symptoms were palpitation (41.4%) shortness of breath (39.1%) and fatigue (26.2%). The prevalent comorbidities associated with atrial fibrillation were congestive heart failure (22.5%), valvular heart diseases (16.6%), and cerebral vascular accident (16.3%). The embolic (32.4%) and thrombotic cerebral vascular accident (16.2%) were the most common type. Major bleeding associated with hospitalization was the most frequent type of bleeding (10 out of 24). (4) Conclusions: Jordanians, using anticoagulation, need to be constantly monitored in terms of their characteristics, symptoms, and any potential complications, to ensure its optimal therapeutic dose and prevent any potential health complications.
The Multifaceted Role of Protoparvoviruses in Human Cutaneous T Cell Lymphoma: From Candidate Causative Agents to Potential Oncolytic Virus Therapeutics
Authors: Angelova Assia , Rommelaere Jean , Ungerechts Guy
Published: January 2024

Cutaneous T cell lymphoma (CTCL) is a devastating, potentially fatal T lymphocyte malignancy affecting the skin. Despite all efforts, the etiology of the disease remains unknown. Infectious agents have long been suspected as factors or co-factors in CTCL pathogenesis. This review deals with the panel of bacterial and viral pathogens that have been investigated so far in an attempt to establish a potential link between infection/carriage and CTCL development. A special focus is given to a recently discovered human protoparvovirus, namely the cutavirus (CutaV), which has emerged as a plausible CTCL etiological agent. Available evidence in support of this hypothesis as well as alternative interpretations and uncertainties raised by some conflicting data are discussed. The complexity and the multifacetedness of the Parvoviridae family of viruses are illustrated by presenting another protoparvovirus, the rat H-1 parvovirus (H-1PV). H-1PV belongs to the same genus as the CutaV but carries a considerable potential for therapeutic applications in cutaneous lymphoma.
Analysis of Yield Threshold in a Functionally Graded Variable Thickness Rotating Disc Using the Tresca Yield Criterion
Authors: khoonbani sina , Ramezanian Hassan
Published: January 2024

The present article investigates the threshold analysis of yielding in a variable thickness rotating disk based on the Tresca criterion. The analysis is conducted on a Functionally Graded Material (FGM) constructed from tailored materials, following the theory of small deformations and for the case of plane stress. The elasticity modulus, density, and yield stress are assumed to be power functions of the radial coordinate. Poisson’s ratio is considered constant due to small variations in different materials. Additionally, the governing equation for the rotating disk is solved analytically. Besides the material type, another factor affecting the distribution of effective stress magnitudes is the cross-sectional shape (profile) of the disk. The thickness of the cross-sectional disk varies radially as a power function. In the current analysis, different conditions for the onset of yielding and the evolution of plastic flow are considered. For evaluation and validation, the obtained results are compared and validated against similar results for specific cases (homogeneous disk and constant thickness graded disk) available in previous references. The results indicate that considering variable thickness for the disk section significantly affects the stresses and the location of the initiation of yielding
Randomized Nonuniform Sampling for Random Signals Bandlimited in the Special Aﬃne Fourier Transform Domain
Authors: Jiang Yingchun , Gao Ni , Li Haizhen
Published: January 2024

The special aﬃne Fourier transform (SAFT) is a useful and powerful analyzing tool in signal processing, optics and communications. In this paper, we mainly discuss the randomized nonuniform sampling and reconstruction for random signals bandlimited in the SAFT domain. First, we show that the nonuniform sampling is identical to the uniform sampling after a pre-ﬁlter in the sense of second order statistic characters. Then, we propose an approximate reconstruction based on sinc interpolation for the nonuniform sampling of random signals bandlimited in the SAFT domain. Finally, we give the mean square error estimate for the proposed approximate recovery approach.
Vertical Center-of-Mass Braking and Motor Performance during Gait Initiation in Young Healthy Adults, Elderly Healthy Adults and Patients with Parkinson’s Disease: A Comparison of Force-Plate and Markerless Motion Capture Systems
Authors: Simonet Arnaud , Delafontaine Arnaud , Fourcade Paul , Yiou Eric
Published: January 2024

Background. The markerless motion capture system (MLS) is a new technology that uses deep learning to detect body segments from digital images. This study tested the agreement between the MLS and a force-plate based system (FPS, “gold standard”) to quantify stability control and motor performance (MP) during gait initiation (GI). Methods. Healthy adults (young and elderly) and patients with Parkinson’s disease (PD) performed GI series at spontaneous and maximal velocity on an FPS while being filmed by an MLS. Signals from both systems were used to compute the peak of forward center-of-mass velocity (indicator of MP) and the braking index (BI, indicator of stability control). Results. Descriptive statistics indicated that both systems detected between-groups differences and velocity effects similarly, while a Bland-Altman (BA) plot anal-ysis showed that BI and MP mean biases were virtually zero in all groups and conditions. Bayes factor 01 indicated strong (for BI) and moderate (for MP) evidence that both systems provided equivalent values. However, trial-by-trial analysis of BA plots revealed the possibility of differ-ences > 10% between the two systems. Conclusion. Although non-negligible differences do occur, MLS appears to be as efficient as FPS in detecting PD and velocity condition effects on BI and MP
Calcium, Potassium and Magnesium in the Induction of Nutraceutical Quality in Tomato Grafted and Cultivated in the NFT System
Authors: Rodríguez Héctor Manuel , Cabrera de la Fuente Marcelino , Benavides Adalberto , Robledo Valentín , Sandoval Alberto , González-Morales Susana , Delgado Rafael
Published: January 2024

Malnutrition problems are related to diets that lack one or more essential elements, which it is extremely important to food enrichment to improve the content of compounds effective for health. The objective of this study is to evaluate the effect of the addition of Ca2+, K+ and Mg2+ on the induction of nutraceutical quality in grafted tomatoes grown in the NFT (Nutrient Film Technique) system. In the experiment, two factors were evaluated: plants with and without grafting and the foliar application of 10 ml L−1 Ca2+, 4 ml L−1 K+ and 10 ml L−1 Mg2+ cations separately for each case, in addition to the control. The treatments were evaluated using a completely randomized design, with 5 repetitions per treatment. The interactive effects between grafting and foliar application of Ca2+ induced a greater content lycopene, β-carotene and total flavonoids in fruits of tomato. The interactive effects between the graft and the Mg2+ foliar applications obtained the best results in the phenol content. As regards, capacity DPPH and ABTS, the graft decreased concentration, increasing the content of these through foliar applications of calcium. Regarding the enzymatic variables, graft factor increased activity catalase, glutathione peroxidase and phenylalanine ammonium lyase, obtained the best results graft interaction and foliar application of calcium and magnesium. The results obtained demonstrate the inﬂuence of the use of grafts and foliar applications of cal-cium and magnesium as tools that could improve the nutraceutical quality content of tomato crop
Synthesis and Biological Evaluation of Novel Amino and Amido Substituted Pentacyclic Benzimidazole Derivatives as Antiproliferative Agents
Authors: Perin Nataša , Gulin Marjana , Gulin Marjana , Persoons Leentje , Daelmans Dirk , Fabijanić Ivana , Stojković Marijana Radić , Hranjec Marijana
Published: January 2024

Newly designed pentacyclic benzimidazole derivatives, featuring amino or amido side chains, were synthesized to assess their in vitro antiproliferative activity. Additionally, we conducted investigations into their direct interaction with nucleic acids, aiming to uncover potential mechanisms of biological action. These compounds were synthesized using conventional organic synthesis methodologies, alongside photochemical and microwave-assisted reactions. Upon synthesis, the newly derived compounds underwent in vitro testing for their antiproliferative effects on various human cancer cell lines. Notably, derivatives 6 and 9 exhibited significant antiproliferative activity within the submicromolar concentration range. Our biological assessment highlighted that the biological activity was strongly influenced by both the position of the N atom on the quinoline moiety and the position and nature of the side chain on the pentacyclic skeleton. Findings from fluorescence, circular dichroism spectroscopy, and thermal melting assays indicated a mixed binding mode—comprising intercalation and the binding of aggregated compounds along the polynucleotide backbone—of these pentacyclic benzimidazoles with DNA and RNA.
Advancements in Drone-Based (UAV) Ground Penetrating Radar for Accurate Boundary Mapping between Disturbed Clayey Soil and Natural Rock
Authors: Frid Michael , Frid Vladimir
Published: January 2024

The main goal of the research is to assess the effectiveness of aerial ground-penetrating radar (GPR) in delineating boundaries between disturbed clayey ground and rock formations along the old Wadi. The study also tackles technical challenges associated with drone-based GPR applications in urban open areas, considering geological heterogeneity, topographic variations, and environmental conditions. The potential of using drone-based GPR equipped with an unshielded dipole antenna as a transformative tool in geospatial analysis was demonstrated. The research encompasses academic insights and field borehole drilling experiments to validate the accuracy and reliability of drone-based GPR data in real-world scenarios. Anticipated contributions include advancements in understanding drone-based GPR technology for mapping disturbed soil boundaries in foundation engineering applications and other relevant areas and recommendations for optimizing its performance in challenging terrains.