bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of concepts of neighbours to knowledge graph completion
Authors: Ferré Sébastien
Published: July 2020

The open nature of Knowledge Graphs (KG) often implies that they are incomplete. Knowledge graph completion (a.k.a. link prediction) consists in inferring new relationships between the entities of a KG based on existing relationships. Most existing approaches rely on the learning of latent feature vectors for the encoding of entities and relations. In general however, latent features cannot be easily interpreted. Rule-based approaches offer interpretability but a distinct ruleset must be learned for each relation. In both latent- and rule-based approaches, the training phase has to be run again when the KG is updated. We propose a new approach that does not need a training phase, and that can provide interpretable explanations for each inference. It relies on the computation of Concepts of Nearest Neighbours (C-NN) to identify clusters of similar entities based on common graph patterns. Different rules are then derived from those graph patterns, and combined to predict new relationships. We evaluate our approach on standard benchmarks for link prediction, where it gets competitive performance compared to existing approaches.
Negative emotion diffusion and intervention countermeasures of social networks based on deep learning
Authors: Cheng Qiuyun , Ke Yun , Abdelmouty Ahmed
Published: July 2020

Aiming at the limitation of using only word features in traditional deep learning sentiment classification, this paper combines topic features with deep learning models to build a topic-fused deep learning sentiment classification model. The model can fuse topic features to obtain high-quality high-level text features. Experiments show that in binary sentiment classification, the highest classification accuracy of the model can reach more than 90%, which is higher than that of commonly used deep learning models. This paper focuses on the combination of deep neural networks and emerging text processing technologies, and improves and perfects them from two aspects of model architecture and training methods, and designs an efficient deep network sentiment analysis model. A CNN (Convolutional Neural Network) model based on polymorphism is proposed. The model constructs the CNN input matrix by combining the word vector information of the text, the emotion information of the words, and the position information of the words, and adjusts the importance of different feature information in the training process by means of weight control. The multi-objective sample data set is used to verify the effectiveness of the proposed model in the sentiment analysis task of related objects from the classification effect and training performance.
A decision-making framework for China’s rare earth industry security evaluation by neutrosophic soft CoCoSo method
Authors: Peng Xindong , Smarandache Florentin
Published: July 2020

The rare earth industry is a crucial strategic industry that is related to the national economy and national security. In the context of economic globalization, international competition is becoming increasingly fierce, and the rare earth industry is facing a more severe survival and development environment than ever before. Although China is the greatest world’s rare earth country in rare earth reserves, production, consumption and export volume, it is not a rare earth power. The rare earth industry has no right to speak in the international market. The comparative advantage is weakening and the security of rare earth industry appears. Therefore, studying the rare earth industry security has important theoretical and practical significance. When measuring the China’s rare earth industry security, the primary problem involves tremendous uncertainty. Neutrosophic soft set (NSS), depicted by the parameterized form of truth membership, falsity membership and indeterminacy membership, is a more serviceable pattern for capturing uncertainty. In this paper, five dimensions of rare earth industry security are identified and then prioritized against twelve different criteria relevant to structure, organization, layout, policy and ecological aspects of industry security. Then, the objective weight is computed by CRITIC (Criteria Importance Through Inter-criteria Correlation) method while the integrated weight is determined by concurrently revealing subjective weight and objective weight. Later, neutrosophic soft decision making method based CoCoSo (Combined Compromise Solution) is explored for settling the issue of low discrimination. Lastly, the feasibility and validity of the developed algorithm is verified by the issue of China’s rare earth industry security evaluation.
What People with Parkinson’s Disease Want
Authors: Andrejack John , Mathur Soania
Published: July 2020

Parkinson’s disease is an incurable, progressive neurodegenerative disease. This condition is complicated by the varying symptoms in individuals who differ in age of onset, symptoms, progression of disease, response to treatment and prognosis. In this paper, we focus on quality of life achieved through a combination of comprehensive health care, continuous support, and self care. Determining what people with Parkinson’s disease want is like assembling multiple puzzles simultaneously. While we surmise that patient centered care, support programs, access to comprehensive health care, and relevant symptom control are pieces of this puzzle, more longitudinal studies— which are observational in nature and correlate the impact of symptoms with patients’ reported needs— are necessary.
Exploring Citizenship: Volunteer Guide
Authors: Rutledge John , Jordan Joy , Pracht Dale , Ellison Stacey
Published: July 2020

The 4-H Citizenship Project offers the opportunity to help 4-H members relate all of their 4-H projects and experiences to the world around them. The 4-H Citizenship manuals will serve as a guide for 4-H Citizenship experiences. To be truly meaningful to the real-life needs and interests of your group, the contribution of volunteer leaders is essential. Each person, neighborhood, and community has individual needs that you can help your group identify. This 6-page Volunteer Guide is a major revision written by John Rutledge, Joy C. Jordan, and Dale Pracht and published by the UF/IFAS Extension 4-H Youth Development program. https://edis.ifas.ufl.edu/4h014

Originally published May 1988.
Common Hazards to Consider during Manufacturing of Feeds for Swine
Authors: Langford Taylor , McKinney Morgan , Carr Chad , Scheffler Jason M
Published: July 2020

This 8-page document discusses common biological, chemical, and physical hazards that may need preventive measures during the manufacture of swine feeds. Written by Taylor Langford, Morgan McKinney, Chad Carr, and Jason M. Scheffler, and published by the UF/IFAS Department of Animal Sciences, September 2019. https://edis.ifas.ufl.edu/an357
Risk Management Planning for Agricultural Business Owners
Authors: Gillen Martie , Pierre Beatrice
Published: July 2020

Risk identification is the beginning point for risk management planning because solution identification begins with knowledge of the problem. This 4-page document presents questions to consider regarding production risk, price or market risk, financial risk, legal risk, and human risk. Written by Martie Gillen and Beatrice Pierre, and published by the UF/IFAS Department of Family, Youth and Community Sciences, August 2019.http://edis.ifas.ufl.edu/fy1485
Worker Protection Standard: Records of Employee Safety Training
Authors: Fishel Frederick M.
Published: July 2020

The EPA’s Worker Protection Standard for Agricultural Pesticides (WPS) covers pesticides used in the outdoor and enclosed-space production of plants on farms, forests, and nurseries, as well as greenhouses. The WPS requires agricultural employers to take steps to reduce pesticide-related risks when agricultural workers and pesticide handlers are exposed to these pesticides. The EPA has made several changes to the WPS since it was fully implemented in 1995, and this new 3-page document addresses maintaining records of worker and handler training under the revised WPS, including a sample employee-training verification. Written by Frederick M. Fishel and published by the UF/IFAS Pesticide Information Office. https://edis.ifas.ufl.edu/pi283
Fusarium Wilt (Fusarium oxysporum f. sp. niveum) of Watermelon
Authors: Roberts Pamela , Dufault Nicholas , Hochmuth Robert , Vallad Gary , Paret Mathews
Published: July 2020

Fusarium wilt of watermelon is one of the most serious and difficult diseases to manage and occurs in most production regions worldwide. The fungus can be seedborne and has great longevity in the soil, allowing infested soil to also serve as a source of infection. This new 4-page publication of the UF/IFAS Plant Pathology Department signs, symptoms, and the disease cycle of Fusarium wilt and provides recommendations for cultural and chemical management. Written by Pamela Roberts, Nicholas Dufault, Robert Hochmuth, Gary Vallad, and Mathews Paret. https://edis.ifas.ufl.edu/pp352
我国畜牧科技信息资源的建设与利用
Authors: 吐尔迅 沙吉旦 • , 赛买提 赛迪古丽 •
Published: July 2020

在近年来的社会发展中,我国畜牧业信息化发展已经得到了极大的进步,信息收集、分析和发布体系相继建成,从而形强化了以市场信息为重点的畜牧业经济体系,在全新的社会发展背景下,畜牧业的生产、经营与管理都实现了发展水平的提升。但与此同时,信息化进程的推动,也使得信息资源建设逐渐成为了畜牧业发展中的瓶颈。基于此,本文就将对畜牧科技信息资源建设和利用进行详细研究,希望对我国农业水平的全面提升奠定良好基础。
园林绿化养护精细化管理对园林景观的影响
Authors: 刘 迪
Published: July 2020

目前我国社会经济正处于飞速发展阶段,使得园林景观工程也随之发展,园林景观不仅可以改善城市环境,满足人们对于生活环境的要求,还可以提高城市绿化水平。园林景观在近几年的应用中越来越广泛,但是在进行园林绿化养护精细化管理时仍然存在着一些问题,这也使得园林景观工程的建设质量和建设水平和预期效果相差较多,对于园林景观工程的发展也具有阻碍作用。本文主要研究和探讨的是园林绿化养护精细化管理对园林景观的影响,希望对于园林工程未来的发展具有促进作用。
Políticas públicas de informação e tecnologia: influências midiáticas
Authors: Stumpf Katiusa
Published: July 2020

Este trabalho é sobre o poder da informação na sociedade contemporânea, destacando-se as relações de poder midiático que se dão neste contexto e as possibilidades de progresso social por meio de políticas públicas de informação e tecnologia comprometidas com os cidadãos. Tendo como método a pesquisa bibliográfica, é desenvolvida uma revisão de literatura possibilitando a discussão acerca das transformações políticas e sócio-culturais que se dão a partir do advento das novas tecnologias de informação e de comunicação das últimas décadas. Com o objetivo de refletir sobre essas questões, destaca-se o acesso à informação por meio de tais tecnologias como possibilidade de fortalecimento da cidadania. Primeiramente são apresentadas algumas definições e ênfase da utilidade de políticas públicas de informação e tecnologia. Em seguida é tratada a questão da influência midiática em políticas públicas de informação e o papel social do profissional bibliotecário nesse panorama. Por fim são apresentadas algumas considerações finais.
Uso de tecnologia leve para o esclarecimento sobre o exame citopatológico de usuárias atendidas em uma Unidade Básica de Saúde no Município DE Ananindeua, Pará, Brasil
Authors: Costa Larissa Kelly Cunha , Cardoso Brenda Crystine da Rocha , Oliveira Letícia Gomes de , Palheta Allan Marcos da Silva , Luz Vania Cristian Sousa da , Aviz Suenne Paes Carreiro de , Quaresma Maycon de Sousa , Martins Breno Pereira , Barbosa Jessica Soares , Vilhena Fabiane Diniz Machado , Pinheiro Fabricio Pantoja , Silva Luceme Martins , Peixoto Ivonete Vieira Pereira
Published: July 2020

O câncer do colo uterino atinge todas as classes sociais e regiões geoeconômicas do país, se tornando um significativo problema de saúde pública. Diante disso, o uso correto da educação em saúde torna-se uma ferramenta indispensável para auxiliar a adoção de medidas de prevenção que necessitam ser desenvolvidas de forma continuada na vida das mulheres. Este trabalho objetivou elaborar uma tecnologia através dos pontos mais importantes levantados pelas participantes para melhor o esclarecimento sobre o exame preventivo. Estudo descritivo de abordagem qualitativa, executado em uma Unidade de Saúde Básica no Município de Ananindeua, Pará, Brasil. A Tecnologia Educativa foi composta por: a) Pontos elencados pelas mulheres na entrevista; b) As lacunas ou demandas de conhecimento identificadas pelas autoras nas entrevistas; c) As ações relatadas pelas mulheres para o esclarecimento sobre o exame preventivo. Para a ilustração utilizou-se o aplicativo “FaceQ” e para a diagramação o Programa Corel DRAW GraphicsSuite X6. Baseado em tudo o que foi evidenciado pelas participantes da pesquisa foi elaborado uma tecnologia leve escolhida para apresentar a este público, sendo este um cartaz para ser fixado na unidade em um local de visibilidade e de fácil acesso objetivando a garantir a eficácia da tecnologia. Considera-se a aplicação de tecnologias educativas em saúde como ferramenta primordial para facilitar o entendimento, no entanto se faz necessários outros estudos e em realidades diferentes para criação de novas tecnologias, com repercussão na redução da morbimortalidade associada ao câncer cervical.
THE DYNAMIC MODEL OF ECONOMIC EQUILIBILITY AS A COMPONENT OF DISTANCE EDUCATION SYSTEMS
Authors: Karpenko M. , Stelma O.
Published: July 2020

The article describes the system model with adjustable parameters and its mathematical analysis. The model allows us to investigate the conditions of achieving economic equilibrium and to consider possible states of the system in this context.
In the model, the economic system is described by the interaction of three components: the producer, the aggregate consumer, and the price regulator. The manufacturer produces two types of products (goods), and its production capacity limits their maximum output. The specific value of production volumes of each type of product is determined by the producer himself, based on current prices. Having fixed specific output volumes, the producer transfers the goods to the domestic market. The consumer, having received this supply, forms the volumes of demand from his side. In this case, the model takes into account the level of prices and preferences of the consumer. Depending on the ratio of supply and demand, products are sold in the model. Volumes of money, which were not covered by supply, are transferred and accumulated in the "unsatisfied supply" fund. Volumes of goods, which were not consumed, are accumulated in the "deferred demand" fund.
According to the results, the model proposes to change the value of prices, if necessary, to introduce a coefficient of price adjustment, after which the process is repeated under new conditions. After a certain number of iterations based on the results of the model, it is possible to obtain the state of the system as well as the history of its formation. This allows us to make a conclusion about the correctness of the pricing strategy and evaluate the obtained results. The described model is implemented as a component of a distance course. The use of computer modeling tools, in combination with e-learning tools, has confirmed their high efficiency.
Keywords: economic equilibrium, mathematical model, imbalance, mathematical analysis, production capabilities, utility function.
Just imagine! The transformative potential of the imagination and its place in psychotherapy
Authors: Wright Sue
Published: July 2020

In this article the author explores the use of imagination and clinical intuition in psychotherapy. She discusses the functions of imagination and how the capacity to be creative and for flexible imagining emerges within a secure attachment relationship in early childhood. Winnicott's ideas are important here. She also discusses what happens when trauma or relationship failings compromise the transitional space and uses case examples to illustrate some responses to this breakdown. To set the scene the author discusses changing views on illusion and imagination from Freud onwards to the present day when we are informed by recent findings in neuroscience and interpersonal neurobiology. It is richly illustrated with theory and case material.
EFFECTS OF PROJECT-BASED ACTIVITIES IN DEVELOPING HIGH SCHOOL STUDENTS’ ENERGY LITERACY
Authors: Lin Kuen-Yi , Lu Shao-Chuan
Published: July 2020

Energy literacy is a key factor in ensuring the protection of the natural environment. Numerous studies on energy literacy have demonstrated the development of instructional methods to promote the willingness to save energy as a critical research subject. Through a project-based activity, this research explored how hands-on activities improve the energy literacy of students. A quasi-experimental design was adopted, namely a pre-test and post-test nonequivalent control group design. In total, 77 senior high school students participated in a 6-week teaching experiment. A single-factor analysis of covariance (ANCOVA) and multiple regression analyses were employed to analyze the collected data. The main findings were as follows: (1) Project-based hands-on activities helped improve the energy literacy of senior high school students; however, the effect was not statistically significant in both experimental and control groups. (2) The key factor influencing the energy conservation behavior of senior high school students was energy-related attitudes following the project-based learning process. Keywords: Energy literacy, project-based activity, senior high school students, solar-powered insect trap.
Sistema móvil de detección de colisión temprana
Authors: Acevedo Roderik , Henríquez Roy , Pan Eddie , Tuñón Carlos , Valderrama Elba
Published: July 2020

Hoy en día los automóviles de última generación traen consigo sistemas que asisten al conductor en múltiples situaciones, como lo son las cámaras de retroceso, sistemas de frenado automático e inclusive, conducción autónoma.  Pero este tipo de tecnología por lo general resulta ser muy costoso para una persona de clase media. Debido a esto, la presente investigación tiene el objetivo de presentar un sistema anticolisión automovilístico que sea económico y accesible para cualquier persona por medio de un dispositivo móvil.
Sistema medidor de amoniaco en la avicultura (megato)
Authors: Gonzalez King Estefany María , Morales Sánchez Ricardo Aaron , Filos Amir
Published: July 2020

El sistema de medición de gases contaminantes en la avicultura es un proyecto de innovación social, desarrollado en pequeñas granjas auto sostenibles y con unidades vulnerables. Este será capaz de alertar a la población cuando los animales están en peligro por gases contaminantes producidos como el amoniaco. Estos gases son capaces de contaminar la carne del animal hasta provocar su muerte, generando pérdidas económicas en la granja y poniendo en riesgo la salud, ya que la carne es para consumo humano en dichas comunidades. El proyecto consiste en una placa controladora de bajo costo, conectada con un circuito de cables y sensores de gas de amoniaco, la cual emitirá niveles, que, al detectar peligro, enviará una programación aplicada al controlador que emite una alerta para tomar medidas como cambiar las camas del ave o ventilar el lugar para que el animal no sufra. Con el sistema de medición vamos a evitar la trasmisión de enfermedades, estos riegos mortales del animal hacia la población o consumidor del producto, también bridarle una manera de automatizar e incluir nuevas tecnologías en sus pequeñas granjas a bajo costo.
AGRICULTURAL AVIATION AT THE CROSS ROADS
Authors: James O.G.
Published: July 2020

Thank you for the opportunity to present this address in my home district, from where I started my business career in aviation in 1949. The 34 years have been eventful, stimulating and satisfying, particularly when it has been said so many times that the agricultural aviation industry has been the single most important development in post war years, in arresting the lost production from New Zealand hill country. The main contribution tq,the threefold increase in stock unit numbers has been the service provided by the aviation industry. It is a record that we, who created it, and spent our working lifetime on, can be justly proud.
EVALUATION OF A TETRAHEDRON SPREADER ON A FIXED-WING AIRCRAFT TO INCREASE FERTILISER SPREAD
Authors: Maber J.F. , Charlton J.F.L.
Published: July 2020

Five combinations of attachments were compared with an unmodified Fletcher aircraft for ability to spread fertiliser granules in a wide swath,over flat land at Napier, North Island. Lateral spread of fertiliser, applied at a nominal rate of approximately 500 kg/ha, was measured by the aircraft flying over a grid of collectors, making two passes for each configuration of attachments. An increase in lateral spread of fertiliser was obtained when theaircraft topdressed in each of the configurations with the tetrahedron spreader fitted but this was accompanied by a marked decrease in rate of application. For example, with the tetrahedron spreader lowered, with streamlining fairings fitted to the front and rear of the hopper outlet, and with accelerator ducts attached to the front f&ring, the swath width increased by 32%. up to 33 m, and the central peak from the distribution pattern, typical of that produced by an unmodified aircraft, was reduced. However the measured application rate fell to approximately 190 kg/ha with this combination of attachments compared with the 427 kg/ha for the unmodified aircraft. Further tests with an unmodrfied aircraft at lower application rates are needed before a direct comparison of swath width can be made. Keywords: Tetrahedron fertiliser spreader, topdressing, lateral spread, fertiliser distribution, hill country
THE MAORI AND HIS LAND
Authors: Christy W.H.
Published: July 2020

#Hei Whatu Ngaro Ngro he Tangata Ko te Kainga Tu tonu ' 'People disappear from sight But the land remains for ever' - Maori Proverb The subject 'The Maori and his Land' has many points of discussion which to the Maori are all very important. It would take up too much time to discuss or list all of them, instead I will take points of interest from articles already written for guidance to Local Government in treating Maori Land, and from another article from the Maori Dominion Council written to assist the Government in forming the new 'Maori Bill'.
SOME ASPECTS OF HILL COUNTRY FARMING ON THE EAST COAST
Authors: Williams J.W.S.
Published: July 2020

The following is my personal view on what it is to be a European meat and wool farmer in the East Cape region. Many of my comments while applying in general to hill country in the whole of the Poverty Bay/East Coast region, are more specific to the area between Cape Runaway in the north, Gisborne City in the south, The Raukumara Range in the west, and the Coastline in the east. The total area is 830,000 hectares, and of this class 7 country (locally known as Category 2 and 3) makes up 45%. Class 8, or Category 4 land, has been excluded from the total area. I will refer to my own property as a typical example of this country, giving some of the pros and cons of farming this land.
TALL FESCUE TOXICITY: AN INVESTIGATION OF IDIOPATHIC BOVINE HYPERTHERMIA (IBH) IN THE NORTH AUCKLAND PENINSULA.
Authors: Kearns M.P.
Published: July 2020

A survey was made of 64 dairy herds, grazing pastures containing naturalised tall fescue in the North Auckland peninsula, to demonstrate an assooation of endophyte fungus in tall fescue with IBH. Of these, 40 farms had cattle with IBH and 24 had no IBH. Endophyte fungus was identtfied in tall fescue samples from all survey farms. Acremonium coenophiolum was demonstrated in samples from almost all farms and a high proportion of these also showed a Phiafophora-like endophyte. No correlation could be shown between the presence of endophyte or any farm management practices such as topdressing etc and IBH. Breed susceptibility was observed in Friesian breeds whilst Jersey cattle were less susceptible. IBH first appeared in November and December with a peak m January. Most affected herds had a hlstory of IBH for many years. Keywords: Dairy cattle, tall fescue toxicity, endophyte fungus, idiopathic bovine hyperthermia, IBH. heat-stress, hyperthermia.
FOR(CED)SALE:HlGH COUNTRY DEVELOPMENT
Authors: Boswell C.C.
Published: July 2020

This is a record of the concepts included in a play 'For(ced) Sale: High Country Development' presented at the 1986 NZ Grassland Association Conference. Three pasture development options considered for high country properties were: 1 . high input nitrogen fertiliser and improved grass; 2. oversown improved legume species and an improved package of management options which are especially applicable to dry sunny faces where establishment has been traditionally difficult; and 3. low input development based on meeting the nutrient requirements of resident legumes using high analysis fertiliser. Aspects of the nitrogen option have been considered by Hall and Scott (1985); the oversown legume option was reviewed by Allan et al. (1985) and some background for the system based on resident legumes was reported by Boswell (1986).
Addressing the Problem of Regional Socio-economic System Management With a Manpower Effective Volume Taken Into Account
Authors: Ketova K. , Rusyak I. , Sedov R.
Published: July 2020

In the paper, a problem of regional socio-economic system management is solved, as exemplified by one of Russia’s regions. An optimal management algorithm is created, with an effective capacity of the workforce taken into account. The statement of the problem is implemented based on a regional economic system macro model, with an effective capacity of a labor force and a physical capital to be viewed as development factors. The underscore preliminary proposition of the model is the fact that labor force effective capacity consists of both qualitative (labor productivity of a worker) and quantitative (labor pool) properties. The product is distributed into consumption, capital widening and sustainment investments, and regional socio-educational development potential. The qualitative property of the workforce is derived from these socio-educational potential investments. Adding a workforce effective capacity factor to the model is the key feature of the management problem statement. The problem-solving algorithm comprises two stages: building an objective optimal balanced growth trajectory and building an optimal trajectory of socio-economic system motion which would propel it to the balanced growth trajectory. The time of transitional period up to reaching an objective balanced growth trajectory can be changed by varying build-up rates of a socio-educational potential. The paper is first to use a two-factor approach in building an optimal investment distribution to solve the problem of socio-economic system management with a workforce effective capacity taken into consideration. Data on demography and volume of investments in educational, production, and social fields of the Udmurt Republic served as an information base of the model. Due to identify unknown parameters of the model, the data as of 2000-2019 was used. Optimal investment rates were calculated which would enable the socio-economic system to reach a balanced growth trajectory by the year 2025. The suggested method can also be used for building a development trajectory for a given socio-economic system, as well as for handling parametrical model calculations to determine their factors.
Source of groundwater iron and manganese in Chandrapur district, central India
Authors: Krishna Kamble Rahul
Published: July 2020

Groundwater
sampling was carried out by grab sampling method from 36 sampling locations
from the Chandrapur district in three seasons i.e. winter, summer, and
post-monsoon. The samples were analysed for physicochemical parameters and
heavy metals i.e. iron and manganese. Data obtained from the study area was
interpreted by using multivariate statistical analysis i.e. principal component
analysis, cluster analysis, correlation matrix and one way ANOVA to ascertain
source apportionment of these two heavy metals. The results of the multivariate
analysis revealed that iron and manganese both were associated with the
lithogenic source. Groundwater irons concentration was higher when compared
with manganese and at a number of sampling locations it was above the
stipulated standard of BIS (Bureau of Indian Standards) (0.3
mg/L).
PENGARUH PEMBERIAN MASSAGE PUNGGUNG TERHADAP KUALITAS TIDUR LANSIA
Authors: Suriany Rotua
Published: July 2020

Kualitas tidur merupakan fisiologis tertentu yang didapatkan   selama seseorang tidur, memulihkan proses-proses tubuh yang terjadi pada waktu orang itu bangun. Kualitas tidur yang buruk pada lansia akan menimbulkan masalah kesehatan lainnya yang berbahaya bagi lansia diantaranya, sering mengantuk di siang hari, cepat lupa dan sulit mengingat sesuatu, tidak berkonsentrasi dalam melakukan sesuatu, kurang semangat, sering marah dan cepat tersinggung. Terapi alternatif untuk meningkatkan kualitas tidur salah satunya dengan pemeberian massage punggung. Massage punggung dapat memperlancar sirkukasi dan meregangkan otot-otot yang tegang, orang yang di massage dapat merasa nyaman dan rileks sehingga meningkatkan kualitas tidur seseorang. Mengetahui pengaruh massage punggung terhadap kualitas tidur lansia di PSTW Budhi Dharma Bekasi 2017.Penelitian ini merupakan jenis eksperimen dengan menggunakan one group pre and post test without control.Pengambilan sampel menggunakan quota sampling sebanyak 12 responden. Dilakukan uji normalitas terlebih dahalu kemudian dilanjutkan ke uji statistik  dengan menggunakan uji Paired T-Test.Ada perbedaan sebelum dan sesudah diberikan intervensi dimana mean sebelum diberikan intervensi 40,75 dan mean sesudah diberikan intervensi 9,75 dengan penurunan 31,00 dan nilai P  0,000. Ada pengaruh pemberian massage punggung terhadap kualitas tidur pada lansia P Value sebesar  0,000.
The 21-Gene Recurrence Score Assay and Prediction of Chemotherapy Benefit: A Propensity Score-Matched Analysis of the SEER Database
Authors: Choi In Sil , Jung Jiwoong , Kim Byoung Hyuck , Oh Sohee , Kim Jongjin , Park Jin Hyun , Park Jeong Hwan , Hwang Ki-Tae
Published: July 2020

Background: To evaluate the performance of the 21-gene recurrence score (RS) assay in predicting chemotherapy benefit in the Surveillance, Epidemiology, and End Results population, we aimed to assess breast cancer-specific mortality (BCSM) by chemotherapy use within each of the RS categories. Methods: Data on breast cancer (BC) cases diagnosed between 2004 and 2015 with available RS results were released. Our analysis included patients with hormone receptor-positive, node-negative early-stage BC (n = 89,402), and three RS groups were defined; RS < 11, low; RS 11–25, intermediate; RS > 25, high. A propensity score matched-analysis was performed to assess and compare BCSM. Results: Chemotherapy was significantly associated with a reduced risk of BC death among patients in the high RS group (hazard ratio = 0.782; 95% CI, 0.618–0.990; p = 0.041). However, in the low and intermediate RS groups, there were no significant differences in BCSM between patients who received chemotherapy and those who did not. Among those with RS 11–25, chemotherapy benefit varied with tumor size (p = 0.001). Conclusions: Our findings provide real-world evidence that the 21-gene RS assay is predictive of chemotherapy benefit among patients in clinical practice. More refined risk estimates would be needed for patients with an intermediate RS.
HLA Evolutionary Divergence as a Prognostic Marker for AML Patients Undergoing Allogeneic Stem Cell Transplantation
Authors: Roerden Malte , Nelde Annika , Heitmann Jonas S. , Klein Reinhild , Rammensee Hans-Georg , Bethge Wolfgang A. , Walz Juliane S.
Published: July 2020

The diversity of human leukocyte antigens (HLAs) enables the presentation of immense repertoires of peptides, including tumor-associated antigens (TAAs). As a surrogate for immunopeptidome diversity, the HLA evolutionary divergence (HED) between individual HLA alleles might directly define the ability to present TAAs, a prerequisite for graft-versus-leukemia effects. We therefore analyzed the impact of HED on survival within a cohort of 171 acute myeloid leukemia (AML) patients after matched donor allogeneic hematopoietic stem cell transplantation (HSCT). Low HED (<25th percentile) of HLA class I (HEDclass I) or HLA-DR antigens (HEDDR) was a strong determinant for adverse overall survival after allogeneic HSCT (OS), with a hazard ratio for death of 1.9 (95% CI 1.2–3.2) and 2.1 (95% CI 1.3–3.4), respectively. Defining a cutoff value for the combined HEDtotal (HEDclass I and HEDDR), the respective 5 year OS was 29.7% and 64.9% in patients with low and high HEDtotal (p < 0.001), respectively. Furthermore, the risk of relapse was significantly higher in patients with low HEDtotal (hazard ratio (HR) 2.2, 95% CI 1.3–3.6) and event-free survival (EFS) was significantly reduced (5 year EFS 25.7% versus 54.4%, p < 0.001). We here introduce HED, a fundamental metric of immunopeptidome diversity, as a novel prognostic factor for AML patients undergoing allogeneic HSCT.
Tumor-Targeting Peptides: The Functional Screen of Glioblastoma Homing Peptides to the Target Protein FABP3 (MDGI)
Authors: Ayo Abiodun , Figueras Eduard , Schachtsiek Thomas , Budak Mazlum , Sewald Norbert , Laakkonen Pirjo
Published: July 2020

We recently identified the glioblastoma homing peptide CooP (CGLSGLGVA) using in vivo phage display screen. The mammary-derived growth inhibitor (MDGI/FABP3) was identified as its interacting partner. Here, we present an alanine scan of A-CooP to investigate the contribution of each amino acid residue to the binding to FABP3 by microscale thermophoresis (MST) and surface plasmon resonance (SPR). We also tested the binding affinity of the A-CooP-K, KA-CooP, and retro-inverso A-CooP analogues to the recombinant FABP3. According to the MST analysis, A-CooP showed micromolar (KD = 2.18 µM) affinity to FABP3. Alanine replacement of most of the amino acids did not affect peptide affinity to FABP3. The A-CooP-K variant showed superior binding affinity, while A-[Ala5]CooP and A-[Ala7]CooP, both replacing a glycine residue with alanine, showed negligible binding to FABP3. These results were corroborated in vitro and in vivo using glioblastoma models. Both A-CooP-K and A-CooP showed excellent binding in vitro and homing in vivo, while A-[Ala5]CooP and control peptides failed to bind the cells or home to the intracranial glioblastoma xenografts. These results provide insight into the FABP3–A-CooP interaction that may be important for future applications of drug conjugate design and development.
Non-Coding RNA Editing in Cancer Pathogenesis
Authors: Romano Giulia , Saviana Michela , Le Patricia , Li Howard , Micalo Lavender , Nigita Giovanni , Acunzo Mario , Nana-Sinkam Patrick
Published: July 2020

In the last two decades, RNA post-transcriptional modifications, including RNA editing, have been the subject of increasing interest among the scientific community. The efforts of the Human Genome Project combined with the development of new sequencing technologies and dedicated bioinformatic approaches created to detect and profile RNA transcripts have served to further our understanding of RNA editing. Investigators have determined that non-coding RNA (ncRNA) A-to-I editing is often deregulated in cancer. This discovery has led to an increased number of published studies in the field. However, the eventual clinical application for these findings remains a work in progress. In this review, we provide an overview of the ncRNA editing phenomenon in cancer. We discuss the bioinformatic strategies for RNA editing detection as well as the potential roles for ncRNA A to I editing in tumor immunity and as clinical biomarkers.
Comprehensive Assessment of TERT mRNA Expression across a Large Cohort of Benign and Malignant Thyroid Tumours
Authors: Pestana Ana , Batista Rui , Celestino Ricardo , Canberk Sule , Sobrinho-Simões Manuel , Soares Paula
Published: July 2020

The presence of TERT promoter (TERTp) mutations in thyroid cancer have been associated with worse prognosis features, whereas the extent and meaning of the expression and activation of TERT in thyroid tumours is still largely unknown. We analysed frozen samples from a series of benign and malignant thyroid tumours, displaying non-aggressive features and low mutational burden in order to evaluate the presence of TERTp mutations and TERT mRNA expression in these settings. In this series, TERTp mutations were found in 2%, only in malignant cases, in larger cancers, and from older patients. TERT mRNA expression was detected in both benign and malignant tumours, with increased frequencies in the malignant tumours with aggressive histotypes, larger tumours, and from older patients. In benign tumours, TERT mRNA expression was found in 17% of the follicular thyroid adenoma (FTA) with increased levels of expression in smaller tumours and associated with the presence of thyroiditis. TERTp mutations and TERT mRNA expression are correlated with worse prognosis features in malignant thyroid tumours, whereas TERT mRNA expression in the benign tumours is associated with the presence of thyroiditis.
Clinical and Molecular Assessment of Patients with Lynch Syndrome and Sarcomas Underpinning the Association with MSH2 Germline Pathogenic Variants
Authors: de Angelis de Carvalho Nathália , Niitsuma Bianca Naomi , Kozak Vanessa Nascimento , Costa Felipe D’almeida , de Macedo Mariana Petaccia , Kupper Bruna Elisa Catin , Silva Maria Letícia Gobo , Formiga Maria Nirvana , Volc Sahlua Miguel , Aguiar Junior Samuel , Palmero Edenir Inez , Casali-da-Rocha José Cláudio , Carraro Dirce Maria , Torrezan Giovana Tardin
Published: July 2020

Lynch syndrome (LS) is a hereditary cancer-predisposing syndrome associated most frequently with epithelial tumors, particularly colorectal (CRC) and endometrial carcinomas (EC). The aim of this study was to investigate the relationship between sarcomas and LS by performing clinical and molecular characterization of patients presenting co-occurrence of sarcomas and tumors from the LS spectrum. We identified 27 patients diagnosed with CRC, EC, and other LS-associated tumors who had sarcomas in the same individuals or families. Germline genetic testing, mismatch repair (MMR) protein immunohistochemistry, microsatellite instability (MSI), and other molecular analyses were performed. Five LS patients presenting personal or family history of sarcomas were identified (3 MSH2 carriers and 2 MLH1), with 2 having Muir–Torre phenotypes. For two MSH2 carriers we confirmed the etiology of the sarcomas (one liposarcoma and two osteosarcomas) as LS-related, since the tumors were MSH2/MSH6-deficient, MSI-high, or presented a truncated MSH2 transcript. Additionally, we reviewed 43 previous reports of sarcomas in patients with LS, which revealed a high frequency (58%) of MSH2 alterations. In summary, sarcomas represent a rare clinical manifestation in patients with LS, especially in MSH2 carriers, and the analysis of tumor biological characteristics can be useful for definition of tumor etiology and novel therapeutic options.
Gas6/Axl Signaling Pathway in the Tumor Immune Microenvironment
Authors: Tanaka Mai , Siemann Dietmar W.
Published: July 2020

Receptor tyrosine kinases have been shown to dysregulate a number of pathways associated with tumor development, progression, and metastasis. Axl is a receptor tyrosine kinase expressed in many cancer types and has been associated with therapy resistance and poor clinical prognosis and outcomes. In addition, Axl and its ligand growth arrest specific 6 (Gas6) protein are expressed by a number of host cells. The Gas6/Axl signaling pathway has been implicated in the promotion of tumor cell proliferation, survival, migration, invasion, angiogenesis, and immune evasion. As a result, Axl is an attractive, novel therapeutic target to impair multiple stages of tumor progression from both neoplastic and host cell axes. This review focuses on the role of the Gas6/Axl signaling pathway in promoting the immunosuppressive tumor microenvironment, as immune evasion is considered one of the hallmarks of cancer. The review discusses the structure and activation of the Gas6/Axl signaling pathway, GAS6 and AXL expression patterns in the tumor microenvironment, mechanisms of Axl-mediated tumor immune response, and the role of Gas6/Axl signaling in immune cell recruitment.
A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies
Authors: Forterre Alexis , Komuro Hiroaki , Aminova Shakhlo , Harada Masako
Published: July 2020

In the field of molecular oncology, microRNAs (miRNAs) and their role in regulating physiological processes and cancer pathogenesis have been a revolutionary discovery over the last decade. It is now considered that miRNA dysregulation influences critical molecular pathways involved in tumor progression, invasion, angiogenesis and metastasis in a wide range of cancer types. Hence, altering miRNA levels in cancer cells has promising potential as a therapeutic intervention, which is discussed in many other articles in this Special Issue. Some of the most significant hurdles in therapeutic miRNA usage are the stability and the delivery system. In this review, we cover a comprehensive update on the challenges and strategies for the development of therapeutic miRNA delivery systems that includes virus-based delivery, non-viral delivery (artificial lipid-based vesicles, polymer-based or chemical structures), and recently emerged extracellular vesicle (EV)-based delivery systems.
Efficient Therapeutic Delivery by a Novel Cell-Penetrating Peptide Derived from Acinus
Authors: Habault Justine , Fraser Claire , Pasquereau-Kotula Ewa , Born-Bony Maëlys , Marie-Cardine Anne , Poyet Jean-Luc
Published: July 2020

In this study, we have identified a novel cell-penetrating sequence, termed hAP10, from the C-terminus of the human protein Acinus. hAP10 was able to efficiently enter various normal and cancerous cells, likely through an endocytosis pathway, and to deliver an EGFP cargo to the cell interior. Cell penetration of a peptide, hAP10DR, derived from hAP10 by mutation of an aspartic acid residue to an arginine was dramatically increased. Interestingly, a peptide containing a portion of the heptad leucine repeat region domain of the survival protein AAC-11 (residues 377–399) fused to either hAP10 or hAP10DR was able to induce tumor cells, but not normal cells, death both ex vivo on Sézary patients’ circulating cells and to inhibit tumor growth in vivo in a sub-cutaneous xenograft mouse model for the Sézary syndrome. Combined, our results indicate that hAP10 and hAP10DR may represent promising vehicles for the in vitro or in vivo delivery of bioactive cargos, with potential use in clinical settings.
EZH2 in Myeloid Malignancies
Authors: Rinke Jenny , Chase Andrew , Cross Nicholas C. P. , Hochhaus Andreas , Ernst Thomas
Published: July 2020

Our understanding of the significance of epigenetic dysregulation in the pathogenesis of myeloid malignancies has greatly advanced in the past decade. Enhancer of Zeste Homolog 2 (EZH2) is the catalytic core component of the Polycomb Repressive Complex 2 (PRC2), which is responsible for gene silencing through trimethylation of H3K27. EZH2 dysregulation is highly tumorigenic and has been observed in various cancers, with EZH2 acting as an oncogene or a tumor-suppressor depending on cellular context. While loss-of-function mutations of EZH2 frequently affect patients with myelodysplastic/myeloproliferative neoplasms, myelodysplastic syndrome and myelofibrosis, cases of chronic myeloid leukemia (CML) seem to be largely characterized by EZH2 overexpression. A variety of other factors frequently aberrant in myeloid leukemia can affect PRC2 function and disease pathogenesis, including Additional Sex Combs Like 1 (ASXL1) and splicing gene mutations. As the genetic background of myeloid malignancies is largely heterogeneous, it is not surprising that EZH2 mutations act in conjunction with other aberrations. Since EZH2 mutations are considered to be early events in disease pathogenesis, they are of therapeutic interest to researchers, though targeting of EZH2 loss-of-function does present unique challenges. Preliminary research indicates that combined tyrosine kinase inhibitor (TKI) and EZH2 inhibitor therapy may provide a strategy to eliminate the residual disease burden in CML to allow patients to remain in treatment-free remission.
Ecologies—A New Multidisciplinary and International Open Access Journal
Authors: Arévalo José Ramón
Published: July 2020

As we head towards the middle of the 21st century, environmental problems become more evident in our planet, in part because of the human pressure on natural resources and also because of the concern of humans about this damage, requiring more specific tools for the evaluation of the negative impacts of human activities, and also the development of restoration tools to confront these problems [...]
Identification of Loci and Pathways Associated with Heifer Conception Rate in U.S. Holsteins
Authors: Galliou Justine M. , Kiser Jennifer N. , Oliver Kayleen F. , Seabury Christopher M. , Moraes Joao G. N. , Burns Gregory W. , Spencer Thomas E. , Dalton Joseph , Neibergs Holly L.
Published: July 2020

Heifer conception rate (HCR) is defined as the percentage of inseminated heifers that become pregnant at each service. The genome-wide association analyses in this study focused on identifying the loci associated with Holstein heifer (n = 2013) conception rate at first service (HCR1) and the number of times bred (TBRD) to achieve a pregnancy. There were 348 unique loci associated (p < 5 × 10−8) with HCR1 and 615 unique loci associated (p < 5 × 10−8) with TBRD. The two phenotypes shared 302 loci, and 56 loci were validated in independent cattle populations. There were 52 transcription factor binding sites (TFBS) and 552 positional candidate genes identified in the HCR1- and TBRD-associated loci. The positional candidate genes and the TFBS associated with HCR1 and TBRD were used in the ingenuity pathway analysis (IPA). In the IPA, 11 pathways, 207 master regulators and 11 upstream regulators were associated (p < 1.23 × 10−5) with HCR1 and TBRD. The validated loci associated with both HCR1 and TBRD make good candidates for genomic selection and further investigations to elucidate the mechanisms associated with subfertility and infertility.
Time Series Analysis and Forecasting with Automated Machine Learning on a National ICD-10 Database
Authors: Olsavszky Victor , Dosius Mihnea , Vladescu Cristian , Benecke Johannes
Published: July 2020

The application of machine learning (ML) for use in generating insights and making predictions on new records continues to expand within the medical community. Despite this progress to date, the application of time series analysis has remained underexplored due to complexity of the underlying techniques. In this study, we have deployed a novel ML, called automated time series (AutoTS) machine learning, to automate data processing and the application of a multitude of models to assess which best forecasts future values. This rapid experimentation allows for and enables the selection of the most accurate model in order to perform time series predictions. By using the nation-wide ICD-10 (International Classification of Diseases, Tenth Revision) dataset of hospitalized patients of Romania, we have generated time series datasets over the period of 2008–2018 and performed highly accurate AutoTS predictions for the ten deadliest diseases. Forecast results for the years 2019 and 2020 were generated on a NUTS 2 (Nomenclature of Territorial Units for Statistics) regional level. This is the first study to our knowledge to perform time series forecasting of multiple diseases at a regional level using automated time series machine learning on a national ICD-10 dataset. The deployment of AutoTS technology can help decision makers in implementing targeted national health policies more efficiently.