bluuebunny/crossref_metadata_2025 huggingface dataset:
Patronage, Politics, and Devotion: The Habsburgs of Central Europe and Jesuit Saints
Authors: Ducreux Marie-Elizabeth
Published: January 2022

The main components of the Habsburgs’ dynastical piety—worship of the Crucified, of the Eucharist, of the Blessed Mary and her spouse St. Joseph—are already well-known. They were common to both branches of the House of Austria, the Spanish as well as the Austrian one. However, they are far from exhausting the variety of manifestations with which they fostered the cult of the saints. More than other sovereigns, Austrian Habsburgs intervened on behalf of patron saints with the popes and the Roman Congregation of Sacred Rites. During the seventeenth century and still in the eighteenth century, they promulgated public feasts in the Austrian hereditary lands as well as in the kingdoms of Hungary and Bohemia. This paper focuses mainly on the veneration they addressed to the Jesuit saints: Ignatius of Loyola, Francis Xavier, Luigi Gonzaga, Stanisław Kostka, and Peter Canisius using archive and printed materials from Rome, Vienna, Prague, and Budapest.
Paphiopedilum charlesworthii var. lannaense, a new slipper orchid from Northern Thailand identified by morphological and AFLP analyses
Authors: TONGKHAM WICHARUJ , PUMIKONG SUPALAK , POTAPOHN NUTTHA , BUNDITHYA WEENUN
Published: January 2022

A new endemic slipper orchid in the family Orchidaceae from Northern Thailand was described according to morphological and molecular analyses. Morphological information specifies the new slipper orchid Paphiopedilum charlesworthii var. lannaense to be similar to Paphiopedilum charlesworthii (Rolfe) Pfitzer 1895, with the exception of its staminode being obovate-obcordate with yellow color, glittery and rough surface. Molecular analysis by AFLP technique indicates that Paphiopedilum charlesworthii var. lannaense can be included as a member of section Paphiopedilum and is closely related to Paphiopedilum coccineum Perner, H. & Herrmann, R. (2000) (syn. Paphiopedilum barbigerum var. coccineum), from which it differs morphologically by dorsal sepal and petal characters. The morphological and molecular evidence supported that Paphiopedilum charlesworthii var. lannaense is a new slipper orchid in the genus Paphiopedilum (Cypripedioideae, Orchidaceae).
Aspergillus sibiricus (Aspergillaceae, Eurotiales), a novel acid-tolerant species in Aspergillus section Fumigati
Authors: ILIUSHIN VADIM A.
Published: January 2022

A novel species in Aspergillus section Fumigati is described as Aspergillus sibiricus. The new species was isolated from an open coal mine in Altai, Siberia, Russia and is represented by ex-type strain CBS 143307. We used a polyphasic taxonomic approach to characterise the species. A description based on morphological features is provided and shows that the new species differs morphologically from closely related species (A. assulatus, A. nishimurae and A. waksmanii). Partial sequences of the loci encoding β-tubulin (BenA), calmodulin (CaM), ribosomal polymerase II second largest subunit (RPB2) and internal transcribed spacer rDNA region (ITS1-5.8S-ITS2) were analyzed as well. Sequences data, macro- and micromorphological and physiological characteristics distinguish A. sibiricus from all known species in section Fumigati, series Unilaterales. A. sibiricus, isolated from an acidic habitat (pH 3.2–3.4), is able to grow at pH 2 and is considered an acid-resistant species.
Fifth contribution to the study of the Lithosiini of Gabon: two genera new for Gabon, with a description of two new species (Lepidoptera: Erebidae: Arctiinae)
Authors: DURANTE ANTONIO , APINDA-LEGNOUO EMELIE ARLETTE
Published: January 2022

Pusiola celida Bethune-Baker, 1911 and Novilema fluminale Durante & Panzera, 2001b are recorded for the first time in Gabon; the synonymy of the subspecies P. celida celida Bethune-Baker, 1911 and P. unipunctana maior Durante & Panzera, 2002a is revised; two species are described as new: Pusiola unicolor Durante new species and Novilema bifurcum Durante new species. The exclusion of Archilema triangulare Durante & Panzera, 2001b from the genus Novilema Durante & Panzera, 2001b is discussed together with criteria for assigning four species of the genus Archilema Birket-Smith, 1965 to the subgenera identified by Birket-Smith (1965). These species are as follows: Archilema (Archilema) lucens Durante & Panzera, 2002c; Archilema (Archilema) subalba Durante & Panzera, 2001b; Archilema (Palilema) quadrilobata Durante & Panzera, 2001b; Archilema (Palilema) triangularis Durante & Panzera, 2001b.
A new species of the waspfish genus Ocosia (Teleostei: Tetrarogidae) from the Coral Sea, with a key to species in the genus
Authors: CHUNGTHANAWONG SIRIKANYA , MOTOMURA HIROYUKI
Published: January 2022

The new waspfish Ocosia dorsomaculata n. sp. (Tetrarogidae) is described, based on specimens from Australia (5) and New Caledonia (51). Although O. dorsomaculata and Ocosia apia Poss & Eschmeyer 1975 both share modally XVI, 8 dorsal-fin rays with a long second dorsal-fin spine, and presence of supraocular, lateral lacrimal, and suborbital spines, the former has modally 13 pectoral-fin rays (vs. usually 12 in the latter), a lower modal count of total gill rakers (10 vs. 16–18), greater upper-jaw length, greater third to sixth dorsal-fin spine lengths, the third dorsal-fin spine slightly shorter than the second dorsal-fin spine (vs. third spine markedly shorter than second spine), 1 or 2 prominent pale brown to dark brown blotches on the membrane between the fifth to eighth or sixth to ninth dorsal-fin spines (vs. 1 blotch on the membrane around the third dorsal-fin spine and 1 blotch on the membrane between the sixth to eighth dorsal-fin spines), and body with 11–15 longitudinal pale brown to dark brown bars along lateral line (vs. irregular brown specks). A key to the species of Ocosia is given.
The Effect of Bone Morphogenetic Protein 2 (BMP-2)/Estrogen Composite Nanoparticles on the Differentiation Function of Osteoporotic Bone Marrow Mesenchymal Stem Cells (BMSCs)
Authors: Ding Shengdi , Xing Shitong , Zhang Zhanfeng , Sun Zhenguo , Dou Xiaojie , He Yu shou , Tang Huibin , Weng Wei
Published: January 2022

The menopausal hormone abnormal changes such as estrogen deficiency and increased FSH secretion in female patients in old age may cause osteoporosis which is plagued by patients. The pathogenesis of osteoporosis is not yet fully understood. BMP in the transforming growth factor-β
superfamily is a key member in the process of bone growth and development, among which BMP-2 exerts critical roles. Impaired osteogenic differentiation of bone marrow mesenchymal stem cells (BMSC) contributes to the progress of osteoporosis. BMSC plays an indispensable role in treating osteoporosis
and can develop into different directions through induction. As the regenerative medicine nanotechnology has become a new medical method, it is believed that BMSC can be used to treat osteoporosis and other related diseases. Our study analyzed the effects of BMP-2/estrogen composite nanoparticles
on the proliferation and differentiation of osteoporotic BMSC cells to provide a reliable reference for the future treatment. Our results showed that BMP-2/estrogen composite nanoparticles promoted BMSC cell proliferation, increased ALP activity, decreased apoptosis rate, increased the expression
of Col-1, Runx2 and Osterix, upregulated the osteogenic marker BMP-2. As confirmed by Alizarin Red staining, it could differentiate into osteoblasts and the content of Trap was decreased. In conclusion, our study confirms that BMP-2/estrogen composite nanoparticles can promote BMSC cell proliferation,
osteogenic differentiation, and inhibit osteoclast differentiation, thereby providing new treatments and theoretical reference basis for treating osteoporosis.
E74-Like Factor 3 Promotes Endometrial Cancer Cell Proliferation, Migration and Invasion via Regulating Mucin 1/Hypoxia-Inducible Factor 1α Pathway
Authors: Guan Xin , Sun Ning
Published: January 2022

High expression of E74-like factor 3 (ELF3) has been reported in type 1 endometrial cancer (EC). Bioinformatics analysis predicted a positive correlation with ELF3 and mucin 1 (MUC1)/hypoxiainducible factor 1α (HIF-1α), a previously identified cancer-promoting
pathway. This study focused on the MUC1/HIF-1α-involved action mechanism of ELF3 in EC. ELF3 expression in EC cell lines was measured by RT-qPCR and western blot analysis. Following the expression of ELF3 was silent, cell proliferation was examined using CCK-8 and colony formation
assay, cell migration and invasion were observed using wound healing and transwell assays. The effect of ELF1 silencing on MUC1/HIF-1α expression was detected by western blot. Rescue experiments incorporating pcDNA3.1(+)/MUC1 explored the interaction between ELF3 and MUC1/HIF-1α
in EC cell proliferation, migration and invasion. ELF3 was found to be expressed at a high level in EC cell lines, and the silencing of it effectively inhibited EC cell proliferation. Moreover, ELF silencing also inhibited the migration and invasion of EC cells. Consistent with the database
prediction, a positive correlation between ELF3 and MUC1/HIF-1α was observed. More importantly, MUC1 overexpression abated the promotive effect of ELF3 silencing on EC cell proliferation, migration and invasion. ELF3 promotes EC cell proliferation, migration and invasion by regulating
MUC1/HIF-1α pathway. Thus, ELF3 as well as MUC1/HIF-1α pathway may be particle targets in the treatment of EC.
Induced Pluripotent Stem Cell-Derived Neural Culture Model of Alzheimer’s Disease: A 3D Organoid Approach
Authors: Fan Wenjuan , Xudong Chen , Yizheng Sun , Wu Shanshan , Wang Haili , Suresh Shoma , Krishnan Sasirekha , Ramalingam Murugan , Deng Jinbo
Published: January 2022

Alzheimer’s disease (AD) is a progressive neurologic disorder that impacts a diverse population of older adults. As three-dimensional (3D) models are powerful tools for advancing AD studies, the authors have been developed AD cortical organoids to enable the observation of AD
pathology at the cellular, tissue, and organ levels. For creating the model, APPSwe/Ind (APP) and PSEN1 (PS1) mutant genes were transfected into mouse induced pluripotent stem cells (iPSCs) following which the iPSC lines that expressed mutant APP and PS1 proteins were obtained. Then, using
modified serum-free suspended embryoid body culture, AD cerebral organoids were made successfully at various ages. The AD model can show AD’s biochemical and pathological alterations, such as overexpressions of Aβ40 and Aβ42 and a decrease of GABAergic interneurons.
The proposed model has the potential for implementation in many biomedical applications, including AD drug screening, stem cell transplant, and neuronal tissue engineering.
Exosomal MicroRNA-23-5p Derived from Bone Marrow Mesenchymal Stem Cells Relieves Inflammatory Response in Rheumatoid Arthritis
Authors: Wu Liangbang , Wang Zui , Hou Zhenhai , Zheng Longbao , Gu Zenghui
Published: January 2022

We aimed to explore the mechanism underlying microRNA-23-5p from exosomes (exo-miR-23-5p) of BMSCs in rheumatoid arthritis (RA). The candidate related genes of miR-23-5p were screened in RA by bioinformatics analysis through gain- and loss-function method along with analysis of histopathological
changes in mice and RAC2 expression as well as the level of pro-inflammatory factors. In vivo RA model was established to detect miR-23-5p’s effect on RA. miR-23-5p level was significantly reduced in RA cells and RAC2 was highly expressed. Expression of RAC2 was inhibited and
targeted by miR-23-5p in RA. Exo-miR-23-5p treatment effectively alleviated joint destruction, reduced inflammatory factor secretion in tissues and serum, as well as decreased RAC2 expression in RA model. In conclusion, the miR-23-5p in the BMSC-exo delays the inflammatory response in RA,
indicating that it might be a new target for treating RA.
Inhibitory Effect of MicroRNA-376b-Overexpressing Bone Marrow Mesenchymal Stem Cells (BMSCs) on Malignant Characteristics of Glioma Cells Through Targeting Forkhead Box Protein P2 (FOXP2)
Authors: Zhu Ruoyu , Wang Zhonglin
Published: January 2022

This study investigated the impact of microRNA (miR)-376b derived from BMSCs on glioma progression. BMSCs were transfected with miR-376b mimic, miR-376b inhibitor or NC and then cocultured with glioma cells followed by measuring cell behaviors by MTT assay, Transwell assay and flow
cytometry, FOXP2 and miR-376b expression by Western blot and RT-qPCR. After confirming the inhibitory and mimicking activity of transfection, we found that overexpression of miR-376b in BMSCs decreased glioma cell invasion, migration and proliferation but promoted cell apoptosis within 24
h and 48 h after transfection along with reduced number of cells in S-phase. Mechanically, miR-376b targeted miR-376b and up-regulation of miR-376b caused down-regulation of FOXP2 (p < 0.05). Overexpression of miR-376b in BMSCs decelerated glioma cell cycle and inhibitedmalignant
behaviors of glioma cells by targeting FOXP2 expression. These evidence unveils the potential role of FOXP2 as a biomarker for the treatment of gliomas.
The Response of the Polar Vortex to Tropospheric Temperature Eddies in an Idealized General Circulation Model
Authors: Ehrmann Thomas S. , Colucci Stephen J.
Published: January 2022

A dry-core idealized general circulation model with a stratospheric polar vortex in the Northern Hemisphere is run with a combination of simplified topography and imposed tropospheric temperature perturbations, each located in the Northern Hemisphere with a zonal wavenumber of 1. The phase difference between the imposed temperature wave and the topography is varied to understand what effect this has on the occurrence of polar vortex displacements. Geometric moments are used to identify the centroid of the polar vortex for the purposes of classifying whether or not the polar vortex is displaced. Displacements of the polar vortex are a response to increased tropospheric wave activity. Compared to a model run with only topography, the likelihood of the polar vortex being displaced increases when the warm region is located west of the topography peak, and decreases when the cold region is west of the topography peak. This response from the polar vortex is due to the modulation of vertically propagating wave activity by the temperature forcing. When the southerly winds on the western side of the topographically forced anticyclone are collocated with warm- or cold-temperature forcing, the vertical wave activity flux in the troposphere becomes more positive or negative, respectively. This is in line with recent reanalysis studies that showed that anomalous warming west of the surface pressure high, in the climatological standing wave, precedes polar vortex disturbances.
The Physics of Heat Waves: What Causes Extremely High Summertime Temperatures?
Authors: Zeppetello Lucas R. Vargas , Battisti David S. , Baker Marcia B.
Published: January 2022

We analyze observations and develop a hierarchy of models to understand heat waves—long-lived, high temperature anomalies—and extremely high daily temperatures during summertime in the continental extratropics. Throughout the extratropics, the number of extremely hot days found in the three hottest months is much greater than expected from a random, single-process model. Furthermore, in many locations the temperature skewness switches from negative on daily time scales to positive on monthly time scales (or shifts from positive on daily time scales to higher positive values on monthly time scales) in ways that cannot be explained by averaging alone. These observations motivate a hierarchy of models of the surface energy and moisture budgets that we use to illuminate the physics responsible for daily and monthly averaged temperature variability. Shortwave radiation fluctuations drive much of the variance and the negative skewness found in daily temperature observations. On longer time scales, precipitation-induced soil moisture anomalies are important for temperature variability and account for the shift toward positive skewness in monthly averaged temperature. Our results demonstrate that long-lived heat waves are due to (i) the residence time of soil moisture anomalies and (ii) a nonlinear feedback between temperature and evapotranspiration via the impact of temperature on vapor pressure deficit. For most climates, these two processes give rise to infrequent, long-lived heat waves in response to randomly distributed precipitation forcing. Combined with our results concerning high-frequency variability, extremely hot days are seen to be state-independent filigree driven by shortwave variability acting on top of longer-lived, moisture-driven heat waves.
Onboarding Salespeople: Socialization Approaches
Authors: Wiseman Phillip , Ahearne Michael , Hall Zachary , Tirunillai Seshadri
Published: January 2022

The effective training of salespeople is crucial to a firm's success; there is arguably no more critical type of training than a salesperson's onboarding. In this study, the authors leverage a natural field experiment in which a firm's newly hired salespeople can undergo onboarding through either a decentralized program or a centralized program to examine the relative impact of each program. Drawing on organizational socialization theory, the authors consider whether an onboarding program that incorporates both individualized and institutionalized socialization tactics (the decentralized program) can develop salespeople into higher performers by encouraging them to take a more innovative and adaptive approach to different facets of the sales role. The findings reveal that salespeople who underwent the decentralized program achieved approximately 23.5% higher sales performance than those who underwent the centralized program. The performance benefits of the decentralized program were amplified for salespeople whose managers had a narrower span of control. In addition, these performance benefits were appreciable for those salespeople transitioning from another job but negligible for those transitioning from school. A scenario-based experiment enriches the field experiment's findings by showing evidence of the theorized mechanism underlying the sales performance benefits observed: the fostering of an innovative role orientation.
Taking Back Teaching: The Professionalization Work of Teacher Activist Organizations
Authors: Carl Nicole Mittenfelner , Jones-Layman Amanda , Quinn Rand
Published: January 2022

We contribute to the teacher activism literature an understanding of how activist organizations support professionalization processes. We examine how teachers’ involvement in a local activist organization counteracts the de-professionalizing reforms of the standards and accountability movement and fosters the professionalization of teaching. Our findings suggest that the structures of the activist organization provide opportunities for teachers to create and maintain collective knowledge for curricula and practice, sustain their professional commitments to social justice, and build confidence that promotes voice in educational decision-making. We discuss implications for teacher professionalization and identify the need for future studies on the role of teacher activist organizations on teachers, teaching, and the profession.
Progress Towards Perennial Grains for Prairies and Plains
Authors: Cassman K.G. , Connor D.J.
Published: January 2022

Perennial grain crops have been proposed as environmentally sustainable alternatives to annual grain crop systems that currently dominate the world's major breadbaskets. Proponents emphasize the potential of perennial grains to mimic natural systems and thereby reduce soil erosion, nutrient losses, and degradation of soil quality although need for adequate grain yield is also recognized as a prerequisite for success. Here we assess progress since 2005 (16 y) towards development of perennial grain systems with sufficient productivity to be seen as competent alternatives to annual wheat on the prairies and plains of North America and Australia. Based on reports published in refereed journals, we see little evidence that yield of Intermediate Wheatgrass or perennial wheats have improved to the point they are viable alternatives. Slow progress is attributed to lack of minimum grain yield targets for economic viability, lack of designated target regions where perennial grains are most likely to be competitive against annuals, selection methods that focused on components of yield rather than yield per se (i.e. on an area basis), and relatively small R & D investment compared to resources given to genetic and agronomic improvement of major annual grain crops. Given current status, we conclude that perennial grains will require substantial R & D investment and several decades if they are to achieve sufficient yield potential and yield persistence to become more than a niche crop for upscale health food markets in wealthy countries.
Collecting Data During the COVID-19 Pandemic: Lessons From an In-Person Survey of People Who Use Opioids
Authors: Jessell Lauren , Zaidi Izza , Dominguez-Gomez Leonardo , Harocopos Alex
Published: January 2022

Objectives:

In response to the COVID-19 pandemic, much in-person data collection has been suspended or become tele-remote. However, tele-remote methods often exclude marginalized groups, including people who use drugs, many of whom lack the technology to participate. To inform future surveillance and research during the pandemic and other public health disasters, we report methods and lessons learned from an in-person survey of people who use opioids conducted by the New York City Department of Health and Mental Hygiene (DOHMH) during the COVID-19 pandemic.

Materials and Methods:

This public health surveillance was a component of the Centers for Disease Control and Prevention Overdose Data to Action initiative and aimed to inform overdose prevention efforts. Survey domains inquired about participants’ drug use patterns, risk behaviors, overdose history, and service use.

Results:

From June 16 through September 9, 2020, DOHMH staff members conducted 329 surveys with participants from 4 syringe service programs (n = 148, 44.9%) and via street intercept (n = 81, 55.1%). To survey participants safely and effectively, it was important to build rapport upfront so that requests to maintain distance were not perceived as stigmatizing. DOHMH staff members offered all participants, regardless of survey eligibility, Narcan and hygiene products, including face masks and soap.

Practice Implications:

Surveys administered outdoors during the COVID-19 pandemic should be limited to 30 minutes. Although conducting in-person surveys poses unique challenges, this method should be considered so marginalized populations are included in data collection and public health responses.
COVID-19 Testing Among US Children, Parental Preferences for Testing Venues, and Acceptability of School-Based Testing
Authors: Teasdale Chloe A. , Borrell Luisa N. , Shen Yanhan , Kimball Spencer , Rinke Michael L. , Rane Madhura S. , Kulkarni Sarah , Fleary Sasha A. , Nash Denis
Published: January 2022

Objectives:

Testing remains critical for identifying pediatric cases of COVID-19 and as a public health intervention to contain infections. We surveyed US parents to measure the proportion of children tested for COVID-19 since the start of the pandemic, preferred testing venues for children, and acceptability of school-based COVID-19 testing.

Methods:

We conducted an online survey of 2074 US parents of children aged ≤12 years in March 2021. We applied survey weights to generate national estimates, and we used Rao–Scott adjusted Pearson χ2 tests to compare incidence by selected sociodemographic characteristics. We used Poisson regression models with robust SEs to estimate adjusted risk ratios (aRRs) of pediatric testing.

Results:

Among US parents, 35.9% reported their youngest child had ever been tested for COVID-19. Parents who were female versus male (aRR = 0.69; 95% CI, 0.60-0.79), Asian versus non-Hispanic White (aRR = 0.58; 95% CI, 0.39-0.87), and from the Midwest versus the Northeast (aRR = 0.76; 95% CI, 0.63-0.91) were less likely to report testing of a child. Children who had health insurance versus no health insurance (aRR = 1.38; 95% CI, 1.05-1.81), were attending in-person school/daycare versus not attending (aRR = 1.67; 95% CI, 1.43-1.95), and were from households with annual household income ≥$100 000 versus income <$50 000-$99 999 (aRR = 1.19; 95% CI, 1.02-1.40) were more likely to have tested for COVID-19. Half of parents (52.7%) reported the pediatrician’s office as the most preferred testing venue, and 50.6% said they would allow their youngest child to be tested for COVID-19 at school/daycare if required.

Conclusions:

Greater efforts are needed to ensure access to COVID-19 testing for US children, including those without health insurance.
Mental health comorbidity and youth onset type 2 diabetes: A systematic review of the literature
Authors: McVoy Molly , Hardin Heather , Fulchiero Erin , Caforio Kate , Briggs Farren , Neudecker Mandy , Sajatovic Martha
Published: January 2022

Background

Type 2 diabetes (T2D) is a burgeoning epidemic in children and adolescents. Adult T2D doubles the risk of depression and mental health comorbidity, makes it more difficult to make the lifestyle, medication adherence and health behavior changes needed to optimize outcomes. There is limited research on the impact of depression and depressive symptoms on youth T2D.

Methods

A search of the literature in the last 10 years regarding youth with depression and T2D was conducted. Abstracts were screened by 2 randomly assigned authors for inclusion, and disagreement was resolved by a third author. Selected full-text articles were divided among all authors for review.

Results

13 publications from 8 studies (N=2244, age 6–17) were included. 6 of 13 publications utilized Treatment Options for Type 2 Diabetes in Youth (TODAY) study data. While studies included evaluation of depressive symptoms, most did not formally assess for major depressive disorder (MDD) and excluded participants with a previous diagnosis of MDD. Depressive symptoms were common in this population and were associated with negative T2D outcomes.

Conclusions

While there is a growing body of adult literature highlighting the extensive relationship between T2D and mental health, there is a dearth of data in youth. Future studies are needed that include, 1.) youth with diagnosed MDD, 2.) treatment studies of both T2D and MDD, 3.) larger, more racially diverse samples of youth with T2D, and 4.) studies that evaluate the impact of social determinants of health, including mental health comorbidity on outcomes of T2D.
Show Me the Numbers: Bureaucratic Use of Data in the Policy Making Process
Authors: Bark Tracey
Published: January 2022

Bureaucracies often provide information to legislatures in an effort to influence the agenda. This paper assesses whether data affects this influence, arguing quantitative support can increase the likelihood of legislative discussion and passage of bills related to a given topic. I also assess the impact of centralization on an agency’s ability to provide information and shape legislative agendas. I find including data in bureaucratic reports can significantly increase an agency’s influence on the legislature, but this effect is only present in a centralized setting. These results suggest centralized agencies are better equipped to marshal quantitative support for arguments to legislatures.
Research on cyber-physical system control strategy under false data injection attack perception
Authors: Wang Zhiwen , Zhang Bin , Xu Xiangnan , Usman  , Li Long
Published: January 2022

This paper investigates the security control problem of the cyber-physical system under false data injection attacks. A model predictive switching control strategy based on attack perception is proposed to compensate for the untrusted sequence of data caused by false data injection attacks. First, the binary attack detector is applied whether the system has suffered the attack. If the attack occurs, multistep correction is carried out for the future data according to the previous time data, and the waiting period [Formula: see text] is set. The input and output sequence of the controller is reconstructed, and the system is modeled as a constant time-delay switched system. Subsequently, the Lyapunov methods and average-dwell time are combined to provide sufficient conditions for the asymptotical stability of closed-loop switched system. Finally, the simulation of the networked first-order inverted pendulum model reveals that the control technique can efficiently suppress the influence of the attacks.
Protection or Restriction: An Analysis of the Blind Massage Policy for Employment Rights of Persons With Visual Impairments in China
Authors: Li Xue Hui , Xu Su Qiong , Hu Luan Jiao
Published: January 2022

Introduction

The United Nations Committee on the Rights of Persons with Disabilities identified the Chinese blind massage policy as “reserved employment” in its Concluding Observations in 2012. In response, this paper reviewed the policy on blind massage in China and discussed its effectiveness and social impact.

Methods:

Adopting a historical perspective, this paper describes the development stages of the blind massage policy in China. It reveals the social construction process of the blind massage policy. Government data were provided to help analyze the positive and negative effects of the policy according to the United Nations’ Convention on the Rights of Persons with Disabilities.

Results:

The blind massage policy is a national strategy involving semi-reserved employment to improve the low employment rate of people with visual impairments in China. It promoted employment of people with visual impairments at the start, but, as the system of the blind massage gradually took shape, it restricted these individuals from choosing a career freely. The blind massage policy has resulted in deep-rooted social prejudices, and it demonstrates disability-based discrimination and charity-oriented practices.

Discussion:

The Chinese blind massage policy is discriminatory and does not reflect the modern concept of disability rights advocated in the United Nations’ Convention on the Rights of Persons with Disabilities.

Implications for Practitioners:

The Chinese government needs to promote institutional reforms to provide better education and employment for people with visual impairments to change the limited content of vocational training and eliminate discriminatory policies.
Pediatric orbital cellulitis: Case report of an unusual etiology and pathogen
Authors: Chew Wen Chao Daniel , Kwek James Wei Ming , Anicete Rosslyn , Low Mei-yi
Published: January 2022

Orbital cellulitis is an uncommon condition with risks to sight and life. As a complication of maxillofacial injuries, the literature suggests this is only possible with fractures or direct inoculation, and there are no reports to the contrary. Here, we make the first report of a possible etiology by which orbital cellulitis developed in a 14-year-old boy even without skin breach or bony fractures; as well as a rare causative pathogen. He presented with facial abscess and progressive orbital cellulitis after blunt facial trauma, requiring functional endoscopic sinus surgery with needle aspiration of facial abscess externally. Cultures showed growth of Streptococcus constellatus/Parvimonas micra, and he received further antibiotics with full recovery.

The pathophysiology of orbital cellulitis in this patient is attributed to vascular congestion and local pressure from maxillofacial contusion and maxillary hemoantrum, with impaired paranasal sinus ventilation encouraging anaerobic bacterial growth. Further progression led to facial abscess formation and intraorbital spread with orbital cellulitis. The pediatric demographic is injury-prone, and self-reporting of symptoms can be delayed. Hence, increased suspicion of complicated injuries and orbital cellulitis may be required when managing maxillofacial contusions so that prompt treatment can be given.
Management of Descending Necrotizing Mediastinitis, a Severe Complication of Deep Neck Infection, Based on Multidisciplinary Approaches and Departmental Co-Ordination
Authors: Ho Chia-Ying , Chin Shy-Chyi , Chen Shih-Lung
Published: January 2022

Objectives

Descending necrotizing mediastinitis (DNM) developing after deep neck infection (DNI) is a potentially lethal disease of the mediastinum with a mortality rate as high as 40% prior to the 1990s. No standard treatment protocol is available. Here, we present the outcomes of our multidisciplinary approaches for treating DNM originating from a DNI.

Methods

Between June 2016 and July 2021, there were 390 patients with DNIs admitting to our tertiary hospital. A total 21 patients with DNIs complicated with DNM were enrolled. The multidisciplinary approaches included establishment of airway security, appropriate surgery and antibiotics, extracorporeal membrane oxygenation, and intensive care unit management. The clinical variables were analyzed.

Results

Two patients died and 19 survived (mortality 9.5%). The patients who died had a higher mean C-reactive protein (CRP) level than did those who survived (420.0 ± 110.3 vs 221.8 ± 100.6 mg/L) (P = .038). The most common pathogens were Streptococcus constellatus and Streptococcus anginosus. From 2001 to 2021, the average mortality rate of studies enrolling more than 10 patients was 16.1%.

Conclusion

Multidisciplinary approaches, early comprehensive medical treatment, and co-ordination among departments significantly reduce mortality. Patients with severe inflammation and high CRP levels require intensive and aggressive interventions.
Caloric adequacy of parenteral nutrition and its influence on the clinical outcome of hospitalised patients
Authors: de Cáceres Carmen , Rico Teresa , Abreu Cristina , Velasco Ana Isabel , Lozano Rafael , Lozano Maria Carmen
Published: January 2022

Background: The adaptation of Parenteral Nutrition (PN) to actual energy requirements of hospitalised patients is essential, since excessive and insufficient nutritional intake have been associated with poor clinical outcomes. Aim: To evaluate the adaptation of prescribed PN to the estimated nutritional requirements using three predictive equations and the influence of excessive/insufficient nutrient intake on patient clinical outcomes (nutritional parameters, metabolic and infectious complications). Methods: Prospective, observational study in hospitalised patients nutritionally assessed. Data was collected the first and fifth/sixth day of PN with clinical (infection, length of hospital stay), biochemical (visceral proteins, cholesterol, glucose, triglycerides, lymphocytes, CRP) and anthropometric parameters (skin folds, height, weight). Theoretical requirements were calculated using Harris-Benedict (HB), Mifflin-St Jeor (MF) and 25 Kcal/Kg/day formulas. The HB formula was used to compare estimated and provided requirements. Results: A total of 94 patients (mean: 72 ± 13.7 years old) were included with initial mean weight and height of 69.2 Kg and 162.8 cm, respectively (mean BMI: 26.1 Kg/m2). No statistically significant differences were found between the actual (1620 Kcal/day) and estimated caloric mean calculated with HB (1643 Kcal/day) and MF (1628 Kcal/day). When comparing with the caloric estimation, 31.9% of patients were underfed, while 14.9% were overfed. Intergroup analysis demonstrated significant variations in albumin, prealbumin, glucose, cholesterol, triglycerides and MUAC, with a significant increase of hyperglycaemia (+37.86; p < 0.05) and hypertriglyceridemia (+63.10; p < 0.05), being higher in overfed patients. Conclusion: In our study, inadequate nutrient intake was associated with a higher degree of hyperglycaemia and hypertriglyceridemia, without positive impact on anthropometric parameters.
Apolipoprotein E ε4/4 genotype limits response to dietary induction of hyperhomocysteinemia and resulting inflammatory signaling
Authors: Seaks Charles E , Weekman Erica M , Sudduth Tiffany L , Xie Kevin , Wasek Brandi , Fardo David W , Johnson Lance A , Bottiglieri Teodoro , Wilcock Donna M
Published: January 2022

Vascular contributions to cognitive impairment and dementia (VCID) are the second leading cause of dementia behind Alzheimer’s disease. Apolipoprotein E (ApoE) is a lipid transporting lipoprotein found within the brain and periphery. The APOE ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease and is a risk factor for VCID. Our lab has previously utilized a dietary model of hyperhomocysteinemia (HHcy) to induce VCID pathology and cognitive deficits in mice. This diet induces perivascular inflammation through cumulative oxidative damage leading to glial mediated inflammation and blood brain barrier breakdown. Here, we examine the impact of ApoE ε4 compared to ε3 alleles on the progression of VCID pathology and inflammation in our dietary model of HHcy. We report a significant resistance to HHcy induction in ε4 mice, accompanied by a number of related differences related to homocysteine (Hcy) metabolism and methylation cycle, or 1-C, metabolites. There were also significant differences in inflammatory profiles between ε3 and ε4 mice, as well as significant reduction in Serpina3n, a serine protease inhibitor associated with ApoE ε4, expression in ε4 HHcy mice relative to ε4 controls. Finally, we find evidence of pervasive sex differences within both genotypes in response to HHcy induction.
Building on a Long Needed Seminal Contribution
Authors: Shapiro Stanley J.
Published: January 2022

Though flattered by the invitation to comment on Laczniak and Shultz's seminal piece, the author did not feel qualified to evaluate either the specifics of the arguments advanced or the conclusions reached. What they said was essentially accepted as a given though the case was made for an accompanying, more reader friendly version of their material. That being so, and after some minor editorial observations are made, much of the remainder of this Commentary focuses on two related issues that seemed especially relevant:(1) Socially Responsible Marketing's role, along with that of Socially Responsible Consumption and Socially Responsible Public policy, both in and of themselves and within a micromarketing Utopia and (2) the fact that after years of relative neglect the concept of macromarketing management seems finally on its way to being resurrected. Four examples of how the complexities of Socially Responsible Marketing could be highlighted using a controversies approach are then presented.
Emergency thrombectomy for cerebrovascular occlusion in a patient with mirror-image dextrocardia: a case report
Authors: Zhang Wensheng , Xing Weifang , Zhong Xiaojing , Zhu Minzhen , He Jinzhao
Published: January 2022

Cases of patients complicated with dextrocardia who suffer from acute cerebral infarction with large vessel occlusion and receive emergency thrombectomy are particularly rare and have not been widely reported. This article aimed to increase the awareness and knowledge of these cases. We report the case of a patient with mirror-image dextrocardia who suffered from cerebral infarction with large vessel occlusion and received emergency thrombectomy. A male patient in his early 60s with dextrocardia had acute cerebral infarction with posterior circulation large vessel occlusion and underwent emergency thrombectomy. During the operation, the rapid confirmation of dextrocardia and use of flexible interventional instruments helped establish a pathway for blood flow. We used an intracranial thrombectomy stent and intracranial balloon dilation catheter to restore the cerebral blood supply. The Modified Rankin Scale score was 0 at 3 months after thrombectomy, indicating a good prognosis of the patient. Acute cerebral infarction with large vessel occlusion in patients with dextrocardia is extremely rare. Emergency thrombectomy is feasible to recanalize cerebral blood flow and give patients a chance to recover.
Parallel Advantage: Further Evidence for Bottom-up Saliency Computation by Human Primary Visual Cortex
Authors: Zhaoping Li
Published: January 2022

Finding a target among uniformly oriented non-targets is typically faster when this target is perpendicular, rather than parallel, to the non-targets. The V1 Saliency Hypothesis (V1SH), that neurons in the primary visual cortex (V1) signal saliency for exogenous attentional attraction, predicts exactly the opposite in a special case: each target or non-target comprises two equally sized disks displaced from each other by 1.2 disk diameters center-to-center along a line defining its orientation. A target has two white or two black disks. Each non-target has one white disk and one black disk, and thus, unlike the target, activates V1 neurons less when its orientation is parallel rather than perpendicular to the neurons’ preferred orientations. When the target is parallel, rather than perpendicular, to the uniformly oriented non-targets, the target’s evoked V1 response escapes V1’s iso-orientation surround suppression, making the target more salient. I present behavioral observations confirming this prediction.
Impact of Face Masks and Viewers’ Anxiety on Ratings of First Impressions from Faces
Authors: Guo Kun , Hare Alexander , Liu Chang Hong
Published: January 2022

Face mask is now a common feature in our social environment. Although face covering reduces our ability to recognize other's face identity and facial expressions, little is known about its impact on the formation of first impressions from faces. In two online experiments, we presented unfamiliar faces displaying neutral expressions with and without face masks, and participants rated the perceived approachableness, trustworthiness, attractiveness, and dominance from each face on a 9-point scale. Their anxiety levels were measured by the State-Trait Anxiety Inventory and Social Interaction Anxiety Scale. In comparison with mask-off condition, wearing face masks (mask-on) significantly increased the perceived approachableness and trustworthiness ratings, but showed little impact on increasing attractiveness or decreasing dominance ratings. Furthermore, both trait and state anxiety scores were negatively correlated with approachableness and trustworthiness ratings in both mask-off and mask-on conditions. Social anxiety scores, on the other hand, were negatively correlated with approachableness but not with trustworthiness ratings. It seems that the presence of a face mask can alter our first impressions of strangers. Although the ratings for approachableness, trustworthiness, attractiveness, and dominance were positively correlated, they appeared to be distinct constructs that were differentially influenced by face coverings and participants’ anxiety types and levels.
Questioning the quest for Pluralism: How Decolonial is Non-Western IR?
Authors: Viramontes Erick
Published: January 2022

Since early 2000s, scholars of international relations have been questioning the Western-centrism of their home discipline and, in a quest for pluralism, have been envisioning ways of conceptualizing the world beyond the West. At the same time, an intellectual movement known as modernity/coloniality research collective has been critically reflecting about modernity and its often-neglected counterpart, coloniality, to resist universalism and to decolonize knowledge. Engaging with the attempts to procure pluralism in the discourse of international relations, the purpose of this article is to question the different perspectives of non-Western international relations from a decolonial angle to identify intellectual projects that could lead to decolonizing the discipline. In its discussion of how decolonial non-Western IR theory is, the article argues that while some perspectives within the subfield openly reject or simply ignore the concerns raised by decolonial thought, others put forward intellectual projects where decolonial arguments resonate. Hence, rather than characterizing the subfield in general terms, the article distinguishes those perspectives that are attentive to the need of generating a true dialog among knowledges and, by so doing, it contributes to critical scholarship within international relations.
Load Combinations for the Evaluation of Redundancy in Steel Bridges
Authors: Bonachera Martin Francisco Javier , Connor Robert J.
Published: January 2022

Over the past decade, there has been considerable interest in the development of quantitative analytical procedures to determine if a primary steel tension member (PSTM) is a fracture critical member (FCM). Traditionally, this designation has most often been arbitrarily determined based simply on the bridge geometry, for example, the number of girders in the cross section, rather than an evaluation of the bridge in the faulted state. Clearly, such a redundancy evaluation must address the loading scenarios concurrent with failure of the PSTM, the likelihood of the member failure, the acceptable probability of load exceeding resistance in the faulted state, and the application of vehicular live load models. This research was conducted to develop a load model and load combinations that are specific to evaluating the performance of a bridge in the event a steel member was to fracture. Specifically, two load combinations were developed to evaluate the strength of a steel bridge, one for the event in which the failure of a PSTM occurs, and another for a post-failure service period. The development adhered to the reliability-based principles and procedures applied in the calculation of load combinations currently used in bridge engineering to facilitate direct implementation and to ensure consistency with current steel bridge design and evaluation procedures contained in the AASHTO LRFD Bridge Design Specifications.
Effects of UV irradiation time on the molecular structure of typical engineering plastics and tribological properties under heavy load
Authors: Liu Lian , Duan Haitao , Zhan Wen , Zhan Shengpeng , Jia Dan , Li Yinhua , Li Changchun , An Jiangfeng , Du Chongwei , Li Jian
Published: January 2022

Exposing engineering plastics to UV irradiation can easily destroy the original molecular structure of the materials and consequently affect their tribological properties. This study investigated the effects of UV irradiation on the molecular structure of typical engineering plastics, such as polytetrafluoroethylene (PTFE) and polyether ether ketone (PEEK), and on their tribological properties under heavy loads (20 MPa). The surface morphology results showed that the appearance of PEEK changed significantly under UV irradiation. However, the change in PTFE was negligible. Under micromorphology, the processing lines of the two materials gradually became lighter with increasing UV irradiation time. The resulting infrared spectra showed that the molecular chains of both materials were broken, and new functional groups were formed under UV irradiation. Tribology testing demonstrated that with prolonged UV irradiation, the average PTFE coefficient of friction remained relatively stable, whereas that of PEEK was approximately 0.55. As the UV irradiation time increased, the wear rate of PTFE increased significantly, whereas that of PEEK showed no significant change.