bluuebunny/crossref_metadata_2025 huggingface dataset:
Identificación del virus del papiloma humano (VPH) en diferentes muestras de pacientes con diagnóstico de lesiones de alto grado en cuello uterino. Estudio piloto en una población colombiana
Authors: Almonacid Isabel Cristina , García Yenni Catherine , Pinzón Eduar Fernando , Cifuentes Claudia Emilce , Almonacid Carmen Cecilia
Published: June 2023

Introducción. El Virus del Papiloma Humano (VPH) es relevante en el desarrollo del cáncer de cérvix, situación que ha conducido a la tamización con citología cérvico-uterina y prueba molecular ADN-VPH que permiten la detección temprana de mujeres en riesgode desarrollar esta patología. Aunque han disminuido la incidencia y mortalidad, no han logrado erradicar la enfermedad. Objetivo. Identificación del VPH en diferentes muestras de pacientes con diagnóstico de lesiones preneoplásicas y cáncer cérvico-uterino. Metodología. Se incluyeron pacientes con lesiones de alto grado (LEI-AG) y/o carcinoma en citología cervicouterina y/o biopsia. Al total se les tomó muestra de sangre, se evaluó la disponibilidad del tejido parafinado (FFPE) y se realizó genotipificación por PCR para VPH. Resultados. 27%(3) LEI-AG estuvieron entre los 30-39 años y 9%(1) en menores de 29; 50%(6) fueron positivas para VPH-AR diferentes al 16-18 en citología en base líquida (CBL) y 16% (1) negativa. Se obtuvo DNA del 100% de los FFPE, con positividad en el 67% (6), 2 (33%) para VPH-16 y 4 (67%) para otros ( 56,58 y 68). 1(11%) presentó coinfección con VPH-56 y 58. 67% (4) mostraron concordancia entre la CBL y el FFPE; 1 fue negativa en CBL y positiva para VPH-56 en FFPE y 1 fue positiva para VPH-18 enCBL y negativa en FFPE. No se obtuvo positividad para VPH en las muestras de plasma analizadas. Conclusión. La relación VPH y cáncer cérvico-uterino requieren desarrollar estudios regionales que permitan su entendimiento y que aporten a las políticas actualmente implementadas en el país.
Diseño y desarrollo de un ambiente virtual de aprendizaje en ventilación mecánica con práctica teleoperada -VENTYLAB
Authors: Toro Córdoba Gloria Isabel , Gomez Villareal Fanny Constanza , García Melo Jose Isidro
Published: June 2023

Introducción. En el contexto de la pandemia Covid-19 y por las restricciones de distanciamiento físico, las universidades se vieron motivadas a configurar métodos de enseñanza alternativos para facilitar la formación de los profesionales de la salud. Objetivo. Describir las consideraciones pedagógicas para el diseño y desarrollo de un ambiente virtual de aprendizaje integrado con tecnología de un Laboratorio remoto para propósitos de práctica en la formación de profesionales de la salud sobre temas de ventilación mecánica. Metodología. En una variación del modelo ADDIE de diseño instruccional y a partir del análisis del contexto, necesidades y revisión de experiencias previas, se diseñan los elementos pedagógicos para la integración de un Ambiente Virtual de Aprendizaje y un sistema de emulación de la mecánica ventilatoria en un entorno llamado Ventylab. Resultados. Desarrollo de un ambiente para la formación de profesionales de la salud, diseñado para que el estudiante aplique el conocimiento sobre fisiopatología cardiopulmonar en la operación de un sistema de ventilación mecánica invasiva. El ambiente considera los recursos educativos, actividades de aprendizaje, comunicación, evaluación e interacción con el laboratorio remoto. Conclusión. El trabajo interdisciplinar para la propuesta pedagógica representó un reto de comunicación y ensamblaje de diferentes saberes. Este trabajo abre puertas para la reflexión hacia la posibilidad de nuevas prácticas de docencia en la formación universitaria sobre temas de ventilación mecánica, así como de aplicación metodológica en otras áreas de conocimiento que requieran práctica.
Nutrición parenteral: la prisión que permite sobrevivir ante una condición de insuficiencia intestinal
Authors: Osorio-Cock Lina María , Giraldo-Villa Adriana , López-Gómez Lina Marcela , Pérez-Ricci Ximena Alejandra , Yepes-Delgado Carlos Enrique
Published: June 2023

Objetivo: la insuficiencia intestinal es la reducción de la función intestinal que requiere la suplementación intravenosa de macronutrientes, agua o electrolitos, pues el intestino no logra la absorción mínima para mantener la salud y el crecimiento. El objetivo es comprender el significado que tiene afrontar la condición de insuficiencia intestinal en pacientes que pertenecen al programa de rehabilitación intestinal del Hospital Pablo Tobón Uribe de Medellín.
Metodología: estudio cualitativo con enfoque hermenéutico que utilizó técnicas de la teoría fundamentada. El muestreo fue primero selectivo y luego teórico. Se realizó un total de 20 entrevistas semiestructuradas; 8 de las cuales tuvieron el aporte de familiares. El análisis inició por la codificación abierta. Los códigos obtenidos se agruparon en categorías descriptivas, y en ellas se identificaron dimensiones y propiedades que se utilizaron para elaborar categorías analíticas mediante la codificación axial y selectiva que permitió emerger la matriz del paradigma final.
Resultados: las necesidades y expectativas de los pacientes con insuficiencia intestinal no son suficientemente atendidas por el sistema de salud, lo que genera mayor incertidumbre sobre el origen de la enfermedad y aún más sobre su futuro. La insuficiencia intestinal y su tratamiento trastornan la vida personal, familiar y laboral. El rechazo social es marcado, por lo que el apoyo familiar y de las personas cercanas es fundamental para lograr la adaptación que les permite revalorar la vida.
Conclusiones: afrontar la condición de insuficiencia intestinal representa la experiencia de requerir necesariamente de nutrición parenteral, la cual se percibe como una prisión que paradójicamente permite sobrevivir.
Structure, variation, and assembly of body-wide microbiomes in endangered crested ibis Nipponia nippon
Authors: Zhu Ying , MA Ruifeng , HU Lei , YANG Haiqiong , GONG Haizhou , He Ke
Published: June 2023

Limited knowledge of bird microbiome in the all-body niche hinders our
understanding of host–microbial relationships and animal health. Here,
we characterized the microbial composition of the crested ibis from 13
body sites, representing the cloaca, oral, feather, and skin habitats,
and explored assembly mechanism structuring the bacterial community of
the four habitats, respectively. The bacterial community characteristics
were distinct among the four habitats. The skin harbored the highest
alpha diversity, most diverse functions, and more complex network,
followed by feather, oral, and cloaca. Individual-specific features were
observed when the skin and feathers were concentrated independently.
Skin and feather samples of multiple body sites from the same individual
were more similar than those from different individuals. Although a
significant proportion of the microbiota in the host (3.5% to 14.5%)
was not derived from the environmental microbiome, as body sites became
more exposed to the environment, the relative importance of neutral
processes increased. Neutral processes were the most important
contributor in shaping the feather microbiome communities (R2=0.859). A
higher percentage of taxa (29.3%) on the skin were selected by hosts
compared to taxa on other body habitats. This study demonstrated that
niche speciation and partial neutral processes, rather than
environmental sources, contribute to microbiome variation in the crested
ibis. These results enhance our knowledge of baseline microbial
diversity in birds and will aid health management in crested ibises in
the future.
Long-term efficacies of selective vasodilators in pulmonary arterial hypertension: A comprehensive comparison using a spontaneous reporting database
Authors: Suzuki Koji , Yagi Tatsuya , Kawakami Junichi
Published: June 2023

Aims: There is no clinical evidence of differences in drugs
associated with long-term survival in patients with pulmonary arterial
hypertension (PAH) due to a small population and the lack of information
on death in the Japanese medical database systems. This study evaluated
whether patient data from a spontaneous reporting database could be used
for comparing the effects of pulmonary vasodilators on long-term
survival in PAH patients. Methods: PAH patient data reported in
the Japanese Adverse Drug Event Report (JADER) database from April 2004
to July 2022 were extracted. Kaplan-Meier curves were used to compare
survival times. Adjusted hazard ratios (aHRs) for all-cause mortality
were determined using Cox proportional hazards models. Results:
Of 1969 PAH patients reported in the JADER database, 1208 patients were
included in the survival analyses. The patient demographics were similar
to those of the PAH population reported in the Japan Pulmonary
Hypertension Registry. Among drugs targeting the prostacyclin pathway,
epoprostenol was most associated with long-term survival (aHR: 0.38;
95% confidence interval [CI], 0.23–0.64). The PAH patients treated
with endothelin receptor antagonists had improved survival, especially
in the macitentan users (aHR: 0.30; 95% CI, 0.22–0.42). Sildenafil was
associated with a poor prognosis in the PAH patients (aHR: 1.56; 95%
CI, 1.19–2.04). Conclusion: Although our results must be
interpreted with caution due to several limitations inherent to
spontaneous reporting databases, our approach using the JADER database
for survival analysis may provide useful information in limited
situations such as the treatment of rare diseases including PAH.
Children’s Oncology Group’s 2023 Blueprint for Research: Behavioral Science
Authors: Embry Leanne , Bingen Kristin , Conklin Heather , Hardy Steven , Jacola Lisa , Marchak Jordan , Paltin Iris , Pelletier Wendy , Devine Katie
Published: June 2023

As survival rates for childhood cancer have improved, there has been
increasing focus on identifying and addressing adverse impacts of cancer
and its treatment on children and their families during treatment and
into survivorship. The Behavioral Science Committee (BSC) of the
Children’s Oncology Group (COG), comprised of psychologists,
neuropsychologists, social workers, nurses, physicians, and clinical
research associates, aims to improve the lives of children with cancer
and their families through research and dissemination of empirically
supported knowledge. Key achievements of the BSC include enhanced
interprofessional collaboration through integration of liaisons into
other key committees within COG, successful measurement of critical
neurocognitive outcomes through standardized neurocognitive assessment
strategies, contributions to evidence-based guidelines, and optimization
of patient-reported outcome measurement. The collection of
neurocognitive and behavioral data continues to be an essential function
of the BSC, in the context of therapeutic trials that are modifying
treatments to maximize event-free survival, minimize adverse outcomes,
and optimize quality of life. In addition, through hypothesis-driven
research and multi-disciplinary collaborations, the BSC will also begin
to prioritize initiatives to expand the systematic collection of
predictive factors (e.g., social determinants of health) and
psychosocial outcomes, with overarching goals of addressing health
inequities in cancer care and outcomes, and promoting evidence-based
interventions to improve outcomes for all children, adolescents, and
young adults with cancer.
Internal erosion process and its influence factors in widely graded loose soils due to rainfall infiltration
Authors: Tian Dalang , Liang Li , Li Zheng-chuan
Published: June 2023

Widely graded loose soils (WGLS), a loose mixture comprising coarse and
fine particles, are widely distributed in the western mountainous areas
of China. Owing to rainfall infiltration, fine particles are eroded and
migrated through the skeleton formed by coarse particles, thus altering
the hydraulic and mechanical characteristics of WGLS. This paper intends
to uncover the internal erosion process and its influencing factors in
WGLS due to rainfall infiltration. To this end, a novel fixed-wall
permeameter is developed, capable of applying an inflow rate-controlled
condition and collecting effluent flowing out of the specimen. A
simplified and cost-effective testing protocol is proposed for
separating eroded silty clay particles, sandy gravel particles, and
seepage water from the collected effluent. Several seepage tests are
conducted on remolded specimens with different inflow rates and initial
porosity utilizing the newly developed experimental setup and testing
protocol. The results indicate four successive erosion stages in the
internal erosion process: the suffusion stage, the suffosion stage, the
piping stage, and the stabilization stage. Six critical hydraulic
gradients correspond to the onset of the various stages. The inflow rate
does not affect the critical hydraulic gradient for suffusion. However,
it significantly impacts the critical hydraulic gradient for suffosion
and subsequent internal erosion behavior. Increasing initial porosity
does not necessarily result in higher erosion potential. These results
are conducive to further understanding the formation mechanism of
internal erosion-induced geologic hazards.
Seasonal and inter-seasonal RSV activity in the European Region during the COVID-19 pandemic from Autumn 2020 to Summer 2022
Authors: Meslé Margaux , Sinnathamby Mary , Mook Piers , Pebody Richard
Published: June 2023

Background: The emergence of the Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) in early 2020 and subsequent implementation
of public health and social measures (PHSM) disrupted the epidemiology
of respiratory viruses. This work describes the epidemiology of RSV
observed during two winter seasons (weeks 40 to 20) and inter-seasonal
periods (weeks 21 to 39) during the pandemic between October 2020 and
September 2022. Methods: Using data submitted to The European
Surveillance System (TESSy) by countries or territories in the World
health Organization (WHO) European Region between weeks 40/2020 and
39/2022, we aggregated country-specific weekly RSV counts of sentinel,
non-sentinel and Severe Acute Respiratory Infection (SARI) surveillance
specimens and calculated percentage positivity. Results for both 2020/21
and 2021/22 seasons and inter-seasons were compared to pre-pandemic
2016/17 to 2019/20 seasons and inter-seasons. Results: Although more
specimens were tested than in pre-COVID-19 pandemic seasons, very few
RSV detections were reported during the 2020/21 season in all
surveillance systems. During the 2021 inter-season, a gradual increase
in detections was observed in all systems. In 2021/22, all systems saw
early peaks of RSV infection, and during the 2022 inter-seasonal period,
patterns of detections were closer to those seen before the COVID-19
pandemic. Conclusion: RSV surveillance continued throughout the COVID-19
pandemic, with an initial reduction in transmission, followed by very
high and out-of-season RSV circulation (summer 2021) and then an early
start of the 2021/22 season. RSV circulation during the 2022/23 season
had not yet normalised.
Gender and the Total Work of Older Workers in Asia
Authors: Donehower Gretchen
Published: June 2023

In Asia, aging countries with slow population growth worry about a lack of workers in the future and see older people’s labor as a potential solution. However, this leaves out the work that many older people already do: unpaid care work. Drawing on data from Bangladesh, India, Mongolia, and Thailand, estimates in this paper show that older people, especially older women, are doing a great deal of work caring for others. Policymakers should take this unpaid care work into account when designing policy around older people’s market labor.
Spatial distribution prediction for the ground water quality in Mosul City (Iraq) using variogram equations
Authors: Ibrahim Abdullah , Al-Tamir Mus'ab A.
Published: June 2023

The GIS-aided spatial interpolation was applied on collected groundwater data to predict selected parameters (i.e., pH, electrical conductivity, and temperature) for the selected water wells distributed over Mosul City in Iraq. A descriptive statistical analysis was conducted on collected samples to explore the statistical indices. The skewness test was also employed to test the distribution of data sets around their mean values. The natural logarithms function achieved least skewness values and thus was applied to transfer data sets in order to adjust normality of the data sets distribution. Among all applied semivariogram models, the J-Bessel semivariogram model was optimal in terms of root mean square error (RMSE) values. The average standard errors were 0.2217, 740.5, and 1.209 for pH, EC, and temperature, respectively.
Diversifikasi Mata Pencaharian di Objek Wisata Talang Indah Kabupaten Pringsewu
Authors: Saraswati Anis , Margaretha Sinaga Risma , Perdana Yusuf
Published: June 2023

This research aims to find out the forms of diversification of people's livelihoods in Talang Indah Tourist Attractions pringsewu regency, as well as the economic classification of the community after the existence of Talang Indah Tourist Attractions Pringsewu Regency. The methods used in this study are qualitatively described with data collection techniques observation, documentation, literature, questionnaires, and interviews. Data analysis techniques used are data reduction, data presentation, and conclusion withdrawal. The results and discussion obtained by researchers are as follows: the community around Talang Indah Tourist Attraction has a variety of sources of income obtained from Talang Indah Attractions both from the agricultural and nonfarm sectors. The source of income of the community is not only from one source, but from several sources, which in this case it is said that the community has a diverse source of income and is commonly referred to as diversification of livelihoods.As for the form of diversification of livelihood after the existence of Talang Indah Tourist Attractions, namely Managers, janitors, security officers, counter guards and traders; as well as the classification of people's livelihoods in Talang Indah Tourist Attraction based on working hours, type of work and income level. The transformation of livelihoods for the community is due to new job opportunities related to Talang Indah Tourist Attractions.
Pengaruh Model Pembelajaran Kooperatif Tipe Kancing Gemerincing (Talking Chips) Terhadap Keaktifan dan Minat Belajar pada Mata Pelajaran IPS Kelas VIII di SMPN 2 Labuhan Maringgai
Authors: Nawang Wulan Dian , Basri Muhammad , Imanita Myristica
Published: June 2023

Proses pembelajaran seseorang guru hendaknya mengetahui latar belakang siswa serta kebutuhan siswa. Penggunaan model pembelajaran yang bervariasi juga dapat meningkatkan keaktifan, dan minat, dalam belajar. Rumusan masalah penelitian ini adalah Apakah ada pengaruh Model Pembelajaran Koopertif Tipe Kancing Gemerincing (Talking Chips)Terhadap Keaktifan Belajar Siswa dan Minat Belajar Pada Mata Pelajaran IPS kelas VIII di SMP Negeri 2 Labuhan Maringgai Tahun Ajaran 2020/2021. Metode yang digunakan adalah Quasi Eksperimental dengan desain Nonequivallent Control Group Design. Teknik pengambilan sampel adalah Purposive Samping. Teknik analisis data menggunakan Uji T dan Uji Regresi Linear. Berdasarkan analisis data yang telah peneliti lakukan dapat ditarik kesimpulan bahwa: Model Pembelajaran Koopertif Tipe Kancing Gemerincing (X) berpengaruh terhadap Keaktifan Belajar (Y1) Siswa Pada Mata Pelajaran IPS kelas VIII di SMP Negeri 2 Labuhan Maringgai Tahun Ajaran 2020/2021 yang dapat terlihat dari uji hipotesis dengan rumus Paired Sampel T-Test yang menunjukan nilai sig(2- tailed) 0.000 < 0.05. Selain itu terdapat pengaruh Model Pembelajaran Kooperatif Tipe Kancing Gemerincing (X), terhadap Minat Belajar siswa (Y2) Pada mata Pelajaran IPS kelas VIII di SMPN 2 Labuhan Maringgai, hasil Uji Regresi Linear Sederhana menunjukan bahwa siswa dapat dilihat dari nilai sig sebesar 0,000 <0,05. Pengaruh Keaktifan Belajar Siswa (Y1) Terhadap Minat belajar siswa (Y2) memiliki pengaruh ketika dilakukan pengujian secara bersamaan hal ini didasarkan atas hasil Uji Regresi Linear Berganda yang menunjukan nilai Signifikan sebesar 0,000 sehingga nilai 0,000 < 0,05 yang artinya H0 Ditolak dan Ha Diterima.
PERAN MASYARAKAT TERHADAP PELESTARIAN LINGKUNGAN MELALUI KEGIATAN PROKLIM DI DUSUN MENDIRO
Authors:   Universitas Pembangunan Nasional ", Telaumbanua Pieter Adam ,   Veteran", Wulandari Cahya Lingga , Putri Sabrina Berliana , Wahyuningtiyas Linda , Wahid Abdul
Published: June 2023

Proklim activities are one of the activities that aim to increase public awareness of the environment, because their role is to create awareness and community cooperation in creating a healthy and clean environment. The aim of Proklim's activities is to create a community that is self-sufficient in terms of climate change resilience with community empowerment-based resilience through good disaster adaptation and mitigation, as well as reducing emissions and Greenhouse Gases (GHG). Mendiro Hamlet is one of the locations where Proklim activities are carried out, because its conditions and potential meet aspects of adaptation and mitigation efforts in climate change. There is conservation land and environmental care activities carried out by the Menduro Hamlet community, creating multi-stakeholder collaboration. So this research is based on descriptive qualitative with primary and secondary data obtained to give results that are in accordance with the reality in the field. Thus the Proklim activities in Mendiro Hamlet were carried out smoothly and produced a clean and healthy environment.
Navigation Strategies by Women into Decision-Making Positions in the Ministry of Education, Zambia
Authors: Kalumba Maybe , Daka Harrison , Kalimaposo Kalisto , Phiri Chidongo , Mulenga-Hagane Lydia Mukuka , Mugala Alex
Published: June 2023

This research aimed to explore the strategies navigated by women employees in the ministry of Education in Decision-Making positions. The objective of the study was to propose strategies that women can use to navigate into being appointed in leadership positions. This study employed a qualitative approach, utilizing in-depth interviews with fifteen (15) women in leadership roles in the Ministry of Education. The participants were selected using purposive sampling, ensuring diversity in age, ethnicity, and position. The data collected from the interviews were analysed using thematic analysis. As such, the study found that women are using various strategies to navigate different challenges, such as building strong networks, seeking mentorship, and developing their leadership skills. It also suggested that women's success in these roles is contingent on addressing gender-based biases and stereotypes, promoting work-life balance, and providing access to mentoring and leadership development programs. The study recommends that, organizations should strive to challenge and change gender stereotypes that limit women's leadership opportunities. Organizations should provide women with access to mentorship and sponsorship programs that help them develop leadership skills and provide them with career guidance. Organizations should offer training and development opportunities that help women build the skills and knowledge needed to succeed in decision-making roles. Equally, that organizations should create a culture that values diversity and inclusion, where everyone's contributions are respected and appreciated. Women should be encouraged to network and build relationships with colleagues and leaders in their field.
КОМП’ЮТЕРНЕ МОДЕЛЮВАННЯ ТА ОПТИМІЗАЦІЯ СКЛАДУ ГІДРОФОБІЗУЮЧОЇ КОМПОЗИЦІЇ
Authors: Данилкович Анатолій , Сангінова Ольга , Шахновський Аркадій
Published: June 2023

В роботі представлені результати комп’ютерного моделювання та оптимізації складу гідрофобізуючої композиції на основі алкенів С20–24, полімеризованих з малеїновим ангідридом. В результаті досліджень запропоновано оптимальний склад наповнювально-гідрофобізуючої композиції, що містить естер С18–22 малеїнової кислоти, парафіни легких фракцій С5–7, етилцелозольв, пропанол, воду, сечовину в такому співвідношенні інгредієнтів: 0,3163 : 0,0770 : 0,0663 : 0,0354 : 0,475 : 0,03. Зазначена композиція має покращувати структурно-визначальні характеристики природних полімерів, зокрема хутрового велюру, отриманого з напівтонкорунних овчин. Застосовано методи експериментально-статистичного моделювання та математичного програмування для знаходження оптимального складу наповнювально-гідрофобізуючої композиції. Оптимізований склад наповнювально-гідрофобізуючої композиції може бути ефективно використаний у технологіях виготовлення овчинно-шубних та шкіряних матеріалів підвищеної водостійкості. За комплексом властивостей отриманий гідрофобізований велюр придатний для виробництва нагольних виробів різного призначення, які експлуатуються в екстремальних умовах.
The punitive-penitentiary system of Transcarpathian Ukraine
Authors: Boldyzhar S.
Published: June 2023

A study of the process of normative-legal regulation of the activity of the punitive-penitentiary system in the territory of Transcarpathia in 1944-1946 was carried out.After the liberation of the territory of Transcarpathia in October 1944 local authorities faced the need to address a number of issues, including the formation of a system of punishments and the implementation of penitentiary activities. The processes of punitive-penitentiary nature took place as a gradual process of transformation, as a result of which Czechoslovak democratic traditions gradually adopted the features of the Soviet administrative-totalitarian system.The implementation of the above tasks began with the proclamation of a full amnesty to citizens of Transcarpathian Ukraine for crimes committed before the liberation of Transcarpathia. At the same time, work on the creation of correctional institutions begins. According to the relevant Resolution of the People’s Council of Transcarpathian Ukraine, a labor camp was established to serve sentences by persons sentenced to imprisonment.In some cases, as a form of punishment, the death penalty could be applied. However, such court decisions were executed only after approval by the People’s Council, which could replace them with imprisonment.At the same time, the leaders of Transcarpathia considered the re-education of offenders to be their main task. Therefore, forced (corrective) labor was considered the main type of punishment for offenders. For its organization, the position of referents for forced labor was established.

At the same time, parole measures, pardon of convicts could be applied, and in cases where trials were inappropriate, a monetary fine was imposed. All this testified to the significant social orientation of state policy in Transcarpathia in the period 1944-1946.
Altruism as an anthropological-biological determinant of the contractual regulation of relations
Authors: Lytvyniuk K.
Published: June 2023

The application of the anthropological and sociological research approach, according to which the patterns of emergence, existence and development of law are determined exclusively by the social dimension of human existence, actually leaves out of consideration the biological nature of the creator of legal norms. And this nature, as confirmed by the results of numerous studies of the behaviour of various social animals, significantly affects the social existence of the latter. Therefore, for the sake of comprehensive knowledge of these regularities, an anthropological and biological approach (based on the recognition of the evolutionary nature of humans and the conditioning of the state and law by certain biological properties of the human individual) should also be applied. This will contribute to interdisciplinary research and the development of legal science based on them.The article is devoted to individual manifestations of human biological nature, namely altruism as an anthropological-biological determinant of contractual regulation of social relations. The concepts and types of this determinant are clarified, and the signs of kin and reciprocal altruism are characterized. It is substantiated that the latter contributes to the spread of social ties and the establishment of norms of physical behaviour. The dependence between the manifestation of altruistic behaviour, the emergence of contractual relations and their regulation in both animals and humans has been demonstrated. A parallel is made with the psychological theory of law of L. Petrażyсki regarding the justification of the emergence of legal relations, in particular, in the field of private contracts. It was concluded that imperative-attributive emotions in the concept of this theorist are a manifestation of mutual altruism. It is noted that altruistic behaviour is aimed at the creating and recognising of protonorms, in particular, the emergence of duties and corresponding rights of a contractual nature. Therefore, the study of individual manifestations of altruism in the environments of animals and people can be useful for deepening the knowledge of the origins of legal regulation.
Дифракція пружних хвиль на сферичних дефектах
Authors: Назаренко О. А. , Стехун А. О. , Яровий А. Т.
Published: June 2023

На основi методу розривних рiшень [2−4] у разi стацiонарних пружних хвиль
запропоновано метод зведення ряду задач дифракцiї до системи iнтегро-диференцiальних
рiвнянь. Дефектом може бути як сферична трiщина, або тонке жорстке сферичне включення.
Деталiзацiя методу розглядається для другого випадку.
Узагальнення методу розривних розв’язкiв [2−4] на випадок сферичних дефектiв (трiщин або
тонких жорстких сферичних включень). Запропоновано метод побудови розривного розв’язку
хвильового рiвняння для сферичної системи координат.
GIRLHOOD AND GIRL FRIENDSHIP IN THE NARRATIVES OF BJØRG VIK AND KARIN SVEEN
Authors: NAN Ioana Gabriela
Published: June 2023

Girlhood and Girl Friendship in the Narratives of Bjørg Vik and Karin Sveen. The article is an account of girls growing up, based on two of Bjørg Vik’s short stories and a novel by Karin Sveen. After introducing the notion of female friendship and girlhood, it places the two authors against the background of Norwegian female authors writing about women and adolescent girls. It goes on to point out the importance of the environment for the girl friendships in the chosen works, and the power hierarchies based on looks that determine the girls’ allegiances. Finally, it comments on the girls’ shifting beliefs in freedom and solidarity as they grow older.
Adolescența și prietenia între adolescente în narațiunile scriitoarelor Bjørg Vik și Karin Sveen. Articolul analizează poveștile inițiatice ale eroinelor adolescente, având ca punct de pornire două nuvele de Bjørg Vik și unul dintre romanele scrise de Karin Sveen. După ce introduce ideile de prietenie feminină și adolescență feminină, articolul prezintă locul celor două autoare în peisajul literar norvegian, alături de alte autoare care scriu despre femei si adolescente. Mai departe, acesta evidențiază rolul mediului familial și social în cazul prieteniilor adolescentine din lucrările alese, precum și relațiile de putere, bazate pe aspectul exterior, ce determină loialitatea adolescentelor. La final, articolul oferă un comentariu referitor la felul în care încrederea protagonistelor în libertate și solidaritate suferă schimbări pe măsură ce acestea se maturizează.
Cuvinte-cheie: literatura feminină, prietenia feminină, adolescența feminină, narațiune inițiatică, solidaritate.
Article history: Received 29 January 2023; Revised 28 April 2023; Accepted 30 May 2023;  Available online 23 June 2023; Available print 30 June 2023.
FLUID LANDSCAPES AND THE INSULAR IMAGINARY IN ROY JACOBSEN’S BARRØY-SERIES
Authors: MOLDOVAN Călina-Maria
Published: June 2023

Fluid Landscapes and the Insular Imaginary in Roy Jacobsen’s Barrøy-series. The paper aims to investigate, through the perspective of the recent new materialist turn in the humanities, the island imaginary in Northern Norway. The research will revolve around Roy Jacobsen’s Barrøy-serien, a series of four books which depict the islands of Northern Norway. The whole world of the islanders seems to be encircled and ultimately enclosed by water. The title of the first volume in the series (The Unseen) points directly toward the socio- and geopolitical invisibility of the inhabitants of the little island, who seem to be outside any social system, living their life off the grid. Islands have been often portrayed in literature as such isolated microcosms, objects of colonial gaze and desire, powerless and inert. However, in Barrøy-serien, Roy Jacobsen seems to break this pattern, by ascribing agency to nonhuman (and more-than-human) systems like the island or the ocean. The story of the protagonist Ingrid seems to slowly become the story of the Barrøy island itself, which is never just the backdrop of human action and intention, but a force that has the power to shape human destinies. I argue that these narratives allow nonhuman entities like the island and the ocean independence and autonomy, acknowledging their enmeshment in human life.
REZUMAT. Peisaje fluide și imaginarul insular în seria de romane Barrøy de Roy Jacobsen. Lucrarea de față își propune să investigheze, prin prisma teoriilor noilor materialisme, un așa numit „imaginar insular” al Norvegiei (de nord). Studiul se concentrează asupra Barrøy-serien de Roy Jacobsen, o serie de patru romane care prezintă realitățile unei insule din nordul Norvegiei. Întreaga lume a locuitorilor insulei pare să fie înconjurată și îngrădită de apă. Titlul primulu volum din serie (Cei Nevăzuți) trimite direct la invizibilitatea socio- și geopolitica a locuitorilor insulei, care par să își trăiască viața în afara oricărui sistem. Insulele au fost adesea portretizate în literatura ca astfel de microcosmosuri izolate, inerte, obiecte ale dorinței și privirii coloniale intrusive. Cu toate acestea, seria de romane scrisă de Roy Jacobsen pare să destabilizeze această structură, atribuind unor sisteme sau entități nonumane (și mai-mult-decât-umane) precum oceanul sau insula Barrøy abilitatea de a se auto-guverna și de a fi autosuficiente. Povestea protagonistei Ingrid pare să devină pe parcursul celor patru volume chiar povestea insulei în sine, care nu este niciodată doar background-ul activității umane, ci o fortă care are puterea să modeleze destine umane. Aceste narațiuni recunosc autonomia și independența unor entități nonumane ca insula sau oceanul, cât și rolul pe care acestea îl au în viața umană.
Cuvinte-cheie: ecocritică, insula, studii nonumane, noi materialisme, peisaj, studii despre ocean
Article history: Received 5 February 2023; Revised 30 April 2023; Accepted 30 May 2023;Available online 23 June 2023; Available print 30 June 2023.
UNE ANALYSE ZOOPOÉTIQUE DU RÉCIT DE VOYAGE "LA PANTHÈRE DES NEIGES" DE SYLVAIN TESSON
Authors: SIMOTA Maria
Published: June 2023

A zoopoetic approach to the travelogue La panthère des neiges by Sylvain Tesson. The present article aims to explore in broad lines the evolution of French zoopoetics thought and its main directions of research. Unlike the anglophone animal studies, the French zoopoetics is offering a slightly different methodology, much more focused on thematic and narratological aspects. In order to exemplify the paradigm shift produced by the zoopoetic approach in France, we will focus our article on Sylvain Tesson’s travelogue La panthère des neiges (2019). The travelogue, through its referential dimension, marks a transition from the generalizing perspective of the animal world to a specific, local and individual approach.
REZUMAT. O analiză zoopoetică a jurnalului de călătorie La panthère des neiges de Sylvain Tesson. Prezentul articol își propune să exploreze în linii mari evoluția gândirii zoopetice franceze și principalele sale direcții de cercetare. Spre deosebire de animal studies din lumea anglofonă, zoopetica franceză oferă o metodologie ușor diferită, mult mai focalizată pe aspecte tematice și naratologice. Pentru a exemplifica schimbarea de paradigmă produsă de abordarea zoopoetică din Franța, vom lua drept studiu de caz jurnalul de călătorie La panthère des neiges (2019) al lui Sylvain Tesson. Mult mai apropiat apropiat de real, acest jurnal marchează o trecere de la perspectiva generalizantă a lumii animale la o abordare specifică, locală și individuală.
 Cuvinte-cheie: animal studies, zoopoetica franceză, literatura de călătorii, Sylvain Tesson.
Article history: Received 17 January 2023; Revised 1 May 2023; Accepted 12 May 2023;Available online 23 June 2023; Available print 30 June 2023.
"How the Personal Profiles of US State Governors Impact on Financial Sustainability"
Authors:   ", ALCAIDE MUÑOZ Laura ,   Associate Professor, Department of Finance and Accounting, Faculty of Business Studies, University of Granada, Granada, Spain ", LÓPEZ SUBIRÉS María Deseada ,   "Assistant Professor, Department of Finance and Accounting, Faculty of Business Studies, University of Malaga, Malaga, Spain", NAVARRO GALERA Andrés ,   "Professor, Department of Finance and Accounting, Faculty of Business Studies, University of Granada, Granada, Spain", RODRÍGUEZ BOLÍVAR Manuel Pedro ,   "Professor, Department of Finance and Accounting, Faculty of Business Studies, University of Granada, Granada, Spain"
Published: June 2023

"This paper considers the extent to which the Governor’s profile might influence the financial sus tainability of the State government, via an empirical study of 50 US States during the period 2006–2013. The results obtained show that financial sustain ability may be prejudiced when the State govern ment experienced financial unsustainability during the previous year, and when it is led by a Governor who is a Democrat, Black, and/or long serving. A favorable influence on financial sustainability is pro duced when the Governor is female, serving in his/ her home State, has children and has a college edu cation. These findings highlight factors that should be considered with respect to promoting financial sustainability via public policies, providing valuable information to facilitate supervision by the State Legislature (General Assembly) and Supreme Audit Institutions. Moreover, these findings enable oppo sition parties and other stakeholders as citizens to evaluate the financial viability of electoral promises."
"The Practicability of Competing Value Framework as a Stride towards Public Service Delivery Improvement in the Health Sector "
Authors:   ", OJOGIWA Oluwaseun Temitope ,   Postdoctoral fellow, SARChI in Sustainable Rural Livelihoods, School of Management, IT and Governance, University of KwaZulu-Natal, KwaZulu-Natal, South Africa", QWABE Bongani Reginald ,   "Senior Lecturer, Department of Public Governance, School of Management, IT and Governance, University of KwaZulu-Natal, KwaZulu-Natal, South Africa"
Published: June 2023

"Considering its impact, organizational culture has emerged as a vital concept in organizational devel opment. Although diagnosing organizational culture appears as one of the organizational change strate gies for organizational development, it is a challeng ing undertaking. The dearth in the evaluation of the organizational culture of the public sector, especially in Nigeria, motivated this study with the aim of evalu ating the organizational culture of the Kwara State public health sector using the Competing Value Framework (CVF). Significantly, there is mounting pressure on the state’s health sector to improve its service delivery, which is likewise strained by the ef fort to contain COVID-19 incidents. Hence, to assess the organizational culture and identify the areas of improvement for an effective proposed organiza tional reform, this study collected data by adminis tering questionnaires to 256 participants. The study found that the prevailing culture is inter nally oriented and it manifests the typical culture of many public institutions. The evaluation of the cur rent and preferred organizational culture is impor tant to identify and create the needed change and most importantly foster a successful organizational transformation in the reality of many failed reforms. Conclusively, a successful change is anticipated to achieve the national goal of the health sector iden tified as one of the global sustainable development goals. "
THE EFFECTIVENESS OF USING SILENT WAY METHOD WITH SPELLING GAME IN IMPROVING STUDENTS’ VOCABULARY MASTERY
Authors: Nur Auliyah  , Muhammad Ihsan  , Dzakiah
Published: June 2023

The objective of this research is to find out whether the use of the silent way with spelling games can improve students’ vocabulary in the eighth grade of SMPN 8 Palu or not. The knowledge of the English language in the eighth grade of SMP 8 Palu is still low, especially in vocabulary. This research aims to obtain empirical evidence about the effect of using the silent way method with spelling games. The population were all eighth-grade students of SMP 8 Palu. The sample were 44 students. The research employs a quasi-experimental design. In the experimental class, the researcher used the silent way method with a spelling game, and in the control class, the researcher used the conventional method strategy (memorizing). The researcher used an instrument in the form of multiple choice and matching tests. The instrument was given in pre-test and post-test. The finding indicated that there was a different score of the final significant mean between the classes, the serve of the experimental class was 73,40 while the final mean of the control class was 63,6. The hypothesis test shows that significant level of 5 % t-test 4,255 > t-table 1,682 so, it can be stated that H0 (Null hypothesis) was rejected and Ha (Alternative hypothesis) was accepted. Therefore, it can be concluded that the use of the Silent Way method with the Spelling Game was effective in improving students’ vocabulary in the eighth grade at SMP 8 Palu in the academic year 2021/2022.
Screen natural terpenoids to identify potential Jab1 inhibitors for treating breast cancer
Authors: Pandey Pratibha , Khan Fahad , Yadav Kiran , Singh Kartikey , Rehman Akhlakur , Mazumder Avijit , Khan Minhaj Ahmad
Published: June 2023

Jab1 (c-Jun activation domain-binding protein-1) overexpression has been extensively linked to cancer development (or metastasis) in various malignancies by positively regulating cancer cell proliferation or inactivating several tumor suppressors. Recent research has focused on utilizing plant products to target crucial elements of dysregulated signaling pathways to elucidate a potent cancer therapeutic approach. Terpenoids have shown significant anti-inflammatory and anti-cancerous properties in a broader range of carcinomas by inducing apoptosis. Through an extensive literature search, we have selected only those terpenoids (from the NPACT database) that have not been explored against Jab1 (CSN5, COP9 signalosome subunit 5) in breast cancer for our research study. We have used two docking servers, PATCH DOCK, and CB DOCK, to find the binding interaction between selected terpenoids and Jab1. Further, we have also used SWISS ADME to investigate the pharmacokinetics of selected ligands. Amongst all selected ligands, lutein (belongs to the xanthophylls class) has displayed maximum binding energy in both CB Dock and Patch Dock analysis. Hence, our preliminary in silico results have shown lutein as the potent lead candidate for developing a better drug against breast cancer. However, more in silico and in vitro studies are still needed to validate the inhibitory potential of lutein terpenoid against Jab1 in breast cancer.
Los virus ¿un paso hacia delante en la evolución?
Authors: Navarro Fernández Ángel , Grande Ana
Published: June 2023

Los virus son indudablemente conocidos por la amplia variedad de enfermedades y problemas que causan a nivel global. Sin embargo, multitud de investigaciones nos permiten entender en cierta medida la verdadera naturaleza de muchos de los virus con los que convivimos todas las especies del planeta. Así pues, se ha visto que muchos de ellos han llegado a establecer relaciones simbióticas con individuos de los distintos reinos. También encontramos dentro del genoma de algunos organismos celulares elementos denominados «transposones», que provienen de la incorporación del material genético de ciertos virus, y que con el paso del tiempo ha pasado a consolidarse como material genético propio de la especie. Existen virus que, por extraño que parezca, también han ayudado a algunos organismos. Nuestra propia especie, por ejemplo, tiene como aliado el pegivirus GBV-C, que puede interferir o incluso llegar a prevenir la infección por HIV-1. De forma similar, los llamados virus oncolíticos, a pesar de no darse en su mayoría de forma natural, son virus modificados genéticamente para su uso en el tratamiento de varios tipos de cáncer. Este artículo pretende mostrar ejemplos de virus que han podido influir positivamente en la evolución de las especies, así como los mecanismos que han empleado.
Transport wilgoci przy przechowywaniu ziarna w silosach. Część I. Model matematyczny transportu wilgoci w złożu
Authors: Szarycz Marian , Kramkowski Ryszard , Kamiński Eugeniusz , Jałoszyński Klaudiusz
Published: June 2023

W pracy przedstawiono analizę transportu wilgoci zachodzącego w złożu zboża magazynowanego w silosach i modele tego transportu w złożu w różnych strefach silosu. Wyróżniono strefy różniące się mechanizmami transportu wilgoci. Stwierdzono, że kluczowym parametrem decydującym o nawilżaniu i wysychaniu zboża w silosie jest rozkład dobowy temperatury otoczenia. Zaproponowano numeryczny opis zmian tej temperatury w cyklach dobowym i rocznym.
Analiza kształtowania się temperatury w belach uzyskanych z siana, także z dodatkiem preparatu ciekłego
Authors: Dulcet Edmund , Borowski Sylwester
Published: June 2023

Przedstawiono analizę przebiegu temperatury w belach sprasowanego siana z dodatkiem 0,2% roztworu kwasu mlekowego i bez tego dodatku. Siano o różnych zawartościach suchej masy prasowano do różnej masy objętościowej. Stwierdzono, że dodatek użytego preparatu obniża temperaturę siana i skraca czas jej stabilizacji. Najniższą temperaturę maksymalną zanotowano w belach siana o najniższej masie objętościowej gk = 99,7 kg·m-3, sprasowanego w warunkach badań.
Processing of mixtures containing chromium-free tannery wastes. Part II. Fertilising value of composts
Authors: Urbaniak Maciej
Published: June 2023

In previous studies (part I) it has been established that methane fermentation of chromium-free tannery wastes results in partly stabilised post-fermentation sludges, rich in nitrogen and phosphorus. This part of the investigations have confirmed that in view of the quality of fertilising material, the composting of post-fermentation sludges is most beneficial; and composting of non-fermented wastes is less beneficial. The sludges from short fermentation (only partly stabilised) and after prolonged fermentation were subjected to composting. The composting of sludges allowed to obtain material, rich in basic fertilising components and organic soil-forming components. The paper shows that it is possible to reduce the arduousness of direct composting (with the omission of fermentation) of chromium-free tannery wastes. The dependence of the quantity of basic fertilising and soil-forming components in the obtained material on the applied processing conditions has been shown.