bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-world evidence of galcanezumab for migraine treatment in Japan: a retrospective analysis
Authors: Takizawa Tsubasa , Ohtani Seiya , Watanabe Narumi , Miyazaki Naoki , Ishizuchi Kei , Sekiguchi Koji , Iba Chisato , Shibata Mamoru , Takemura Ryo , Hori Satoko , Nakahara Jin
Published: December 2022

Objective

To evaluate the efficacy and safety of galcanezumab in patients with migraine in a real-world setting in Japan.

Background

Galcanezumab is the first anti-calcitonin gene-related peptide monoclonal antibody approved in Japan. To the best of our knowledge, no real-world studies on galcanezumab have been published in any international journal from Japan.

Methods

We retrospectively examined patients with migraine who received three doses of galcanezumab between August 2021 and February 2022 at the Keio University Hospital. We assessed changes in monthly migraine days, responder rate, and migraine-associated and premonitory symptoms. We also investigated injection site reactions and adverse events.

Results

Fifty-two patients received three doses of galcanezumab during the study period. Compared with those at baseline, the monthly migraine days decreased by 5.9 days (95% confidence interval, 4.2–7.7) at 3 months. The 50% responder rate was 61.5% at 3 months. A total of 64.9%, 50.0%, and 63.9% of patients showed improvement in the severity of photophobia, phonophobia, and nausea/vomiting, respectively. Premonitory symptoms without subsequent headache were reported in 62.5% of patients. Moreover, injection site reaction was the most common adverse event (34.6%).

Conclusion

This study revealed the efficacy and safety of galcanezumab for migraineurs in Japan. Galcanezumab also improved migraine-associated symptoms. However, despite a reduction in headaches, premonitory symptoms without subsequent headache were reported in > 50% of the patients at 3 months.
Microbial identification from traumatized immature permanent teeth with periapical lesions using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
Authors: Sharaf Pervine H. , El Backly Rania M. , Sherif Raef A. , Zaazou Ashraf M. , Hafez Soad F.
Published: December 2022

Background

This study aims at identifying the microbiota in traumatized immature permanent teeth with periapical lesions using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS).

Methods

The study included 16 immature maxillary central incisors with periapical lesions in 13 patients. Field decontamination and negative control samples were performed before and after access cavity preparation. Root canal samples were taken using sterile stainless-steel hand files following field decontamination. In-office inoculation and pure sub-cultures were performed. Bacterial isolates were prepared for MALDI-TOF MS (Bruker, Billerica, MA USA) analysis using the formic acid extraction method. A comparison of the prevalence of isolated microorganisms was done using a one-sample chi-square test. Comparisons between identified microbial species with the, cone beam computed tomography periapical index (CBCT PAI) scores and lesion volume were also conducted. The Chi-square test was applied to investigate the association between the categorical variables .

Results

Out of the forty isolates recovered from the 16 traumatized teeth included in the present study with the mean patients’ age of 10.93 ± 1.77, 37 isolates were reliably identified by MALDI-TOF MS. Twelve teeth (62.5%) were polymicrobial. The recovered bacteria belonged to five phyla, 15 genera and 25 species. Firmicutes were the predominant phylum (P < 0.001) over Bacteroidetes, Proteobacteria, Actinobacteria and Fusobacteria. Gram positive bacteria were significantly more prevalent than Gram negative (p = 0.03). Facultative anaerobes were the most prevalent (P < 0.001) compared to the obligate anaerobes and the obligate aerobes. The latter were the least prevalent. Statistically, significant differences existed in the comparison between CBCT PAI scores according to bacterial gram staining.

Conclusion

Traumatized immature permanent teeth with periapical lesions showed a significant predominance of Gram-positive facultative anaerobes. MALDI-TOF MS provided accurate identification of numerous viable endodontic microbes.
Efficacy and safety of pyronaridine-artesunate (Pyramax®) for the treatment of uncomplicated Plasmodium vivax malaria in Northwest Ethiopia
Authors: Mohammed Hussein , Sime Heven , Hailgiorgis Henok , Chernet Melkie , Alebachew Mihreteab , Solomon Hiwot , Assefa Gudissa , Haile Mebrahtom , Girma Samuel , Bekele Worku , Tasew Geremew , Gidey Bokretsion , Commons Robert J. , Assefa Ashenafi
Published: December 2022

Background

Declining efficacy of chloroquine for the treatment Plasmodium vivax malaria has been reported in different endemic settings in Ethiopia. This highlights the need to assess alternative options for P. vivax treatment with artemisinin-based combination therapy, such as pyronaridine-artesunate. This treatment regimen has shown high efficacy for uncomplicated malaria in both Africa and Asia. However, limited data are available from Ethiopia. This study was conducted to assess the efficacy and safety of pyronaridine-artesunate for the treatment of uncomplicated P. vivax malaria in Northwest Ethiopia.

Methods

A single arm prospective efficacy study was conducted in the Hamusite area, Northwest Ethiopia. Fifty-one febrile adult patients with uncomplicated P. vivax malaria were enrolled between March and July 2021. Patients were treated with pyronaridine-artesunate once daily for three days. Clinical and parasitological parameters were monitored over a 42-day follow-up period using the standard World Health Organization protocol for therapeutic efficacy studies.

Results

A total of 4372 febrile patients were screened with 51 patients enrolled and 49 completing the 42-day follow-up period. The PCR-uncorrected adequate clinical and parasitological response (ACPR) was 95.9% (47/49; 95% CI 84.9–99.0) on day 42. Two patients had recurrences [4.0% (2/49); 95% CI 0.7–12.1] on days 35 and 42. The parasite clearance rate was rapid with fast resolution of clinical symptoms; 100% of participants had cleared parasitaemia on day 1 and fever on day 2. All 16 (31.4%) patients with gametocyte carriage on day 0 had cleared by day 1. There were no serious adverse events.

Conclusion

In this small study, pyronaridine-artesunate was efficacious and well-tolerated for the treatment of uncomplicated P. vivax malaria. In adults in the study setting, it would be a suitable alternative option for case management.
Increase of depression among children and adolescents after the onset of the COVID-19 pandemic in Europe: a systematic review and meta-analysis
Authors: Ludwig-Walz Helena , Dannheim Indra , Pfadenhauer Lisa M. , Fegert Jörg M. , Bujard Martin
Published: December 2022

Background

Research points to a high depression burden among youth during the COVID-19 pandemic; however, a lack of systematic evidence exists. We determine the change in depression symptoms among children and adolescents during COVID-19 compared to pre-pandemic baselines. By using country differences in pandemic-related restrictions and school closures in Europe as quasi-experimental design, we evaluate policy impacts on depression.

Methods

In this systematic review and meta-analysis, following the PRISMA statement, we searched six databases (MEDLINE, EMBASE, PsycINFO, Cochrane Central, Web of Science, WHO COVID-19) using a peer-reviewed search string up until March 18, 2022 with citation tracking and grey literature searches. No limitations regarding language and effect measures existed. We included studies that compared (1) general depression symptoms or (2) clinically relevant depression rates in children and adolescents (≤ 19 years) before and during the COVID-19 pandemic in Europe. The validated Oxford Stringency Index was used as indicator for pandemic-related restrictions. Screening for eligibility, extracting data from published reports and from unpublished data requested directly from study authors, assessing the study risk of bias and grading certainty of evidence using the GRADE approach, were all done in duplicate. Data were pooled in a random-effects model. PROSPERO: CRD42022303714.

Results

Of 7,422 nonduplicate records, 22 studies with data from 868,634 participants pre-pandemic and 807,480 during pandemic, met full inclusion criteria. For the comparison of depression symptoms before and during the COVID-19 pandemic, moderate certainty of evidence was observed for general depression symptoms (standardized mean difference, 0.21 [95%CI, 0.12–0.30]; I2 = 94%) and low certainty of evidence for clinically relevant depression rates (odds ratio, 1.36 [95%CI, 1.05–1.76]; I2 = 95%) for total population. Increase in general depression symptoms was higher for male adolescents, whereas increase in clinically relevant depression rates was higher for females. Effect estimates were significantly higher when pandemic-related restrictions were more stringent or school closure occurred.

Conclusion

An increase in depression symptoms occurred in a pre-pandemic vs. during-pandemic comparison within the COVID-19 pandemic, whereby pandemic-related restrictions (such as school closures) resulted in a considerable effect increase. Ensuring adequate supply of mental health recovery services and long-term monitoring is of high public health relevance.
Understanding youths’ concerns about climate change: a binational qualitative study of ecological burden and resilience
Authors: Thomas Isaiah , Martin Andrés , Wicker Antoine , Benoit Laelia
Published: December 2022

Background

Climate change has been shown to have long-term effects on mental health, yet, to date, there have been few studies on how children and adolescents experience and respond to ecological changes and how and why they engage in climate action. We explored empirically young people’s views about climate change and how distinct cultural contexts influence individual climate action.

Methods

We invited children and adolescents (ages 7 to 18) and their caregivers from the general population in the United States and France to participate in semi-structured focus groups. We recruited 74 participants, 39 in the U.S. (33 children and adolescents, 6 parents) and 35 in France (32 children and adolescents, 3 parents). Focus groups with participants centered on their emotions, beliefs, and actions around climate change. We analyzed the focus group data and developed themes via grounded theory and symbolic interactionist approaches.

Results

Many participants described experiencing anger, hopelessness, guilt, and sadness in response to climate change, and a smaller number endorsed significant anxiety symptoms; many described frustration about needing to fix the mistakes of earlier generations. Younger participants frequently misunderstood the purpose of their parents’ eco-conscious behaviors unless they were provided with age-appropriate explanations. Participants described a spectrum of experiences when trying to discuss climate change with peers and family, ranging from genuine support to apathy to hostility. Between the two samples, U.S. participants experienced more conflict with adults about climate change than French participants, but French participants described a greater lack of political agency compared to U.S. participants. Participants in both samples expressed a relatively balanced view of climate action, recognizing the significance of individual actions while acknowledging the limits of their power in the face of systemic issues. Some found hope and empowerment through climate action and building communities around it.

Conclusion

Discussing with children and adolescents what adults are doing to mitigate climate change can provide reassurance, model prosocial behaviors, and inspire their own investment in climate action. Adults seeking to support the psychological well-being of young people should both support their concerns and actions around climate change and create avenues for young people to meaningfully engage in climate action.
miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response
Authors: Cuttano Roberto , Colangelo Tommaso , Guarize Juliana , Dama Elisa , Cocomazzi Maria Pia , Mazzarelli Francesco , Melocchi Valentina , Palumbo Orazio , Marino Elena , Belloni Elena , Montani Francesca , Vecchi Manuela , Barberis Massimo , Graziano Paolo , Pasquier Andrea , Sanz-Ortega Julian , Montuenga Luis M. , Carbonelli Cristiano , Spaggiari Lorenzo , Bianchi Fabrizio
Published: December 2022

Locally advanced non-small cell lung cancer (NSCLC) is frequent at diagnosis and requires multimodal treatment approaches. Neoadjuvant chemotherapy (NACT) followed by surgery is the treatment of choice for operable locally advanced NSCLC (Stage IIIA). However, the majority of patients are NACT-resistant and show persistent lymph nodal metastases (LNmets) and an adverse outcome. Therefore, the identification of mechanisms and biomarkers of NACT resistance is paramount for ameliorating the prognosis of patients with Stage IIIA NSCLC. Here, we investigated the miRNome and transcriptome of chemo-naïve LNmets collected from patients with Stage IIIA NSCLC (N = 64). We found that a microRNA signature accurately predicts NACT response. Mechanistically, we discovered a miR-455-5p/PD-L1 regulatory axis which drives chemotherapy resistance, hallmarks metastases with active IFN-γ response pathway (an inducer of PD-L1 expression), and impacts T cells viability and relative abundances in tumor microenvironment (TME). Our data provide new biomarkers to predict NACT response and add molecular insights relevant for improving the management of patients with locally advanced NSCLC.
Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells
Authors: Leung Adrian On-Wah , Yiu Tsz-Ching , Liu Lingxiao , Tam Hei-Yin , Gu Shen , Tu Jiajie , Pei Duanqing , Cheung Hoi-Hung
Published: December 2022

Background

Pathogenic mutations inWRNare a cause of premature aging disease Werner syndrome (WS). Besides accelerated aging phenotypes and cancer predisposition, patients with WS also display underdevelopment in the skeletal system, characterized by short stature, light body weight and unusually thin extremities. The reasons for these developmental defects are not completely understood and the underlying molecular mechanism remains to be elucidated.

Results

In this study, WRN was found to modulate transcription ofshort stature homeoboxgeneSHOX. Loss of WRN resulted in insufficient expression of SHOX, the gene dose of which is critical for driving chondrocyte differentiation. WRN could bind the G-quadruplex (G4) structures in theSHOXpromoter and stimulate transcription. Aberrant formation of G4 structures in WRN-deficient cells impeded normal transcription of SHOX, thus resulting in impaired chondrogenesis. Chondrogenesis could be rescued by overexpression of WRN helicase or SHOX, suggesting that SHOX is a downstream target of WRN. Gene editing of the G4 structures in theSHOXpromoter could increase SHOX expression, therefore rescuing the impaired chondrogenesis in WRN-deficient cells.

Conclusions

Our data suggest that dysgenesis of the developing bone in WS might be caused by SHOX insufficiency. Aberrant formation of G4 structures inSHOXpromoter suppresses SHOX expression and impairs chondrogenesis. Targeted mutagenesis in the G4 structures enhances SHOX expression and thus providing an opportunity to rescue the chondrogenic defect.
Effects of using a snooze alarm on sleep inertia after morning awakening
Authors: Ogawa Keiko , Kaizuma-Ueyama Emi , Hayashi Mitsuo
Published: December 2022

Background

Many people use the snooze function of digital alarm clocks for morning awakening, but the effects of a snooze alarm on waking are unclear. We examined the effects of a snooze alarm on sleep inertia, which is a transitional state characterized by reduced arousal and impaired cognitive and behavioral performance immediately upon awakening.

Methods

In study 1, healthy Japanese university students responded to a sleep survey during a psychology class (study 1), and we collected 293 valid responses. In study 2, we compared a separate sample of university students (n = 10) for the effects of using or not using a snooze alarm on sleep inertia immediately after awakening from normal nocturnal sleep in a sleep laboratory.

Results

Of 293 valid respondents in study 1, 251 often used a tool to wake up in the morning (85.7%). Moreover, 70.5% reported often using the snooze function of their mobile phones, mainly to reduce anxiety about oversleeping. Study 2 indicated no differences in the sleep quality or quantity before awakening with or without the snooze alarm, except in the last 20 min. However, during the last 20 min of sleep with snooze alarm, the snooze alarm prolonged waking and stage N1 sleep. Stage N1 sleep is non-rapid eye movement sleep that is primarily defined as a drowsy state. Furthermore, Global Vigor values were enhanced after awakening compared to pre-sleep in the no-snooze condition.

Conclusions

Using a snooze alarm prolongs sleep inertia compared to a single alarm, possibly because snooze alarms induce repeated forced awakenings.
The impact of emotional leadership on Chinese subordinates’ work engagement: role of intrinsic motivation and traditionality
Authors: Wan Jin , Zhou Wenjun , Qin Mingyue , Zhou Haiming , Li Pingping
Published: December 2022

Background

Leaders’ emotions and emotion regulation strategies influence subordinates’ attitudes and behaviors, while previous studies have mostly taken an emotional perspective. Leaders’ emotional competence also has an impact on subordinates through motivational and cognitive pathways. Based on self-determination theory, this study examined the impact of emotional leadership on subordinates’ work engagement, as well as the mediating role of subordinates’ intrinsic motivation and the moderating role of traditionality.

Methods

We first performed a scenario experiment study in which 116 Chinese college students were asked to read experimental materials on different leadership behaviors and answer relevant questions. Subsequently, a questionnaire survey was conducted, in which 347 Chinese enterprise employees were asked to rate their own experiences with emotional leadership, work engagement and intrinsic motivation. We used SPSS 25.0 for performance reliability analysis, correlation analysis and hierarchical regression analysis to test the reliability of the scales and investigate the relationship between the variables. Bootstrap analysis was used to test the mediating and moderating effects.

Results

Emotional leadership has a significant direct positive effect on subordinates’ work engagement and positively influences subordinates’ work engagement through the mediation of subordinates’ intrinsic motivation. The effect of emotional leadership on intrinsic motivation is stronger for those with high traditionality than for those with low traditionality.

Conclusion

Emotional leadership can improve subordinates’ work engagement by stimulating their intrinsic motivation. Therefore, managers need to be able to effectively regulate and manage subordinates’ emotions to stimulate their intrinsic motivation and to differentiate the management of subordinates with different levels of traditionality to improve subordinates’ work engagement.
Feasibility and preliminary efficacy of training health workers in detecting Priority Mental Health Conditions among adolescents in rural South India
Authors: Siddaiah Archana , Srinivasan Krishnamachari , Satyanarayana Veena , Ekstrand Maria L.
Published: December 2022

Introduction

Half of all mental disorders start during adolescence, before 14 years. In India, the current prevalence of mental disorders in 13–17 years age group was 7.3%. Many gaps persist in the mental healthcare delivery through the national mental health program, the low psychiatrist population ratio being one of them. Community health workers can play an essential role in providing mental healthcare in such resource-constrained settings. The World Health Organization mental health gap action program (WHO mhGAP) is a widely studied mental health tool that health workers can use to identify mental disorders. The study’s aim was to test the preliminary efficacy of training healthcare workers (HCWs) in identifying mental health conditions among adolescents using modified WHO mhGAP modules.

Methods

The feasibility study was carried out in two Primary Health Centers (PHCs) in rural Bengaluru. Study had two components: (1) training of HCWs on adolescent mental health and (2) detection of selected priority mental health conditions among adolescents by trained HCWs. HCWs were trained in five adolescent mental health conditions using a training manual and modified WHO mhGAP modules that excluded emergency presentations and management sections. Pre- and post-training assessments were carried out. A sample of 272 adolescents attending PHCs were assessed for any mental health condition by HCWs using mhGAP modules. A sub-sample of adolescents and all adolescents identified by HCWs with a mental health condition was interviewed by the investigator to validate the diagnosis. Qualitative interviews were carried out with participating HCWs to understand the acceptability of the intervention, acceptability, and barriers to training in identifying mental health conditions among adolescents

Results

A total of 23 HCWs underwent training. There was a significant increase in the mental health knowledge scores of HCWs post-training compared to baseline (p value <0.001). Out of 272 adolescents, 18 (6.8%) were detected to have any mental health condition by HCWs as per the modified WHO mhGAP modules. A sample of 72 adolescents consisting of all adolescents identified with a mental health condition by HCWs and a random sample of adolescents without any diagnosis were validated by the research investigator (AS). There was a good agreement between diagnosis by health workers and the research investigator with a Cohen’s Kappa of 0.88. Four themes emerged from the qualitative analysis.

Conclusions

Training was effective in improving the knowledge of HCWs. There was a good agreement between trained HCWs and the investigator in detecting adolescent mental health conditions using modified mhGAP modules. The modified WHO mhGAP can thus be used by trained non-specialist HCWs to screen for adolescent mental health conditions in primary health centers.
Association of methylation status of ABCA1/G1 genes with the risk of coronary artery disease
Authors: Mansouri Elaheh , Esmaeili Fataneh , Montaseri Maryam , Emami Mohammad Amin , Koochakkhani Shabnaz , Khayatian Mahmood , Zarei Hasan , Turki Habibollah , Eftekhar Ebrahim
Published: December 2022

Background

ATP-binding cassette transporters A1/G1 (ABCA1/G1) is a main regulator of HDL (high-density lipoprotein) formation and reverse cholesterol transport. Impaired ABCA1/G1 genes function may seriously affect cholesterol homeostasis, leading to increased risk of cardiovascular disease. In the present study, the association of ABCA1/G1 genes methylation status with the risk of coronary artery disease (CAD), risk factors of CAD, and serum level of lipid parameters was investigated.

This study was conducted on 70 CAD patients and 40 control subjects. All CAD subjects with diabetes mellitus were excluded. The promoter methylation status of ABCA1/G1 genes was determined by the methylation-specific polymerase chain reaction (MS-PCR) method and serum lipid parameters were assessed using commercial kits.

Results

ABCA1 promoter methylation was higher in CAD group compared to the control participants (80% vs. 60%). Hypermethylation of the ABCA1 gene significantly increases the risk of CAD in the total population (OR 3.886, 95% CI (1.181–12.791), p = 0.026). ABCG1 methylation status showed no difference between CAD and control subjects. In addition, no significant association was noted between methylation status of ABCA1/G1 and serum level of lipid profile.

Conclusions

Altogether, our study shows that ABCA1 gene promoter hypermethylation may increase the risk of CAD, which may help identify people at risk of developing CAD.
Redesign of water filter using design for manufacturing and assembly to minimize cost and time
Authors: Balqis Ignadia Zain , Rusindiyanto Rusindiyanto , Widjajati Endang Pudji
Published: December 2022

Kembang Belor Village is one of the villages that have a water resource but are not yet precisely utilized and need a water filter. The current water filter is not suited for users’ needs because they cannot afford it. Therefore, this research intends to redesign the water filter. This research aims to reduce production costs and increase the efficiency of design and assembly time. The method employed is Design for Manufacturing and Assembly (DFMA). The results show that the production cost decreased by 50.83%; design efficiency increased by 37.5%; production, handling, and assembly time improved by 51.7%, 33.3%, and 52.7% for each; the number of ppm decreased from 142 to 95. For the contribution, few previous research uses the DFMA method to analyze and redesign the water filter. These findings contribute in helping the user recognize new options to design efficient water filters for future needs.
Flower Visitation by Bees, Wasps and Ants: Revealing How a Community of Flower-Visitors Establish Interaction Networks in a Botanical Garden
Authors: Menezes Mariana R. , Laviski Bianca F. S. , Dos Santos Adriano P. L. , De França Eder C. B. , Moreira Mariane S. , Conceição-Neto Ricardino , Queiroz Jarbas M.
Published: December 2022

The Hymnoptera order includes several flower-visiting insects (e.g. ants, bees, and wasps) and the coexistence of many different species in the same community can generate interspecific competition. Notwithstanding shared communities, research which evaluates how these taxonomic groups influence a whole community of flower-visiting Hymenoptera is lacking. Moreover, abiotic factors can also impact these floral visits, because each organism responds differently to climatic variations. The goal of this study is to evaluate abiotic factors, specifically relative air humidity and air temperature, which may be able to impact the number and the frequency of interactions between hymenopterans and flowers and to assess the composition and niche organization, by making use of interaction networks, of the entire community of flower-visiting Hymenoptera at the botanical garden of the Universidade Federal Rural do Rio de Janeiro. For the duration of a year, we took samples in that botanical garden, compartmentalizing the collections temporally in accordance with the time of the insects’ shift (morning or afternoon). We observed a positive influence of air temperature on the number of ant interactions and visits. It is also possible to observe that most of these interaction networks exhibited a nested and non-modular pattern and an average level of network specialization. In addition, bees stood out as the species with the highest frequency of visits and with the most generalist behavior. This study demonstrates how a botanical garden can sustain a diverse community of floral visiting Hymenoptera in an urban environment and why it consists in an important tool for biodiversity conservation.
Resistir
Authors: Zahner Maria Eliza
Published: December 2022

Este trabalho propõe uma visão alternativa aos conceitos tradicionais do estudo de literatura de testemunho, apresentando a ideia da escrita pela resistência da identidade. Baseando-nos nas obras de Márcio Seligmann-Silva sobre o trauma, a representação e o papel do historiador, podemos notar a prevalência do conceito “trauma” nesses estudos: o termo é amplamente utilizado para entender a motivação de sobreviventes de eventos-limite em sua escrita. A partir disso, pensamos em outros conceitos que podem ser utilizados nesse estudo, como a angústia, o luto e a resistência. Leremos, então, as autoras Ruth Klüger e Scholastique Mukasonga como exemplos de sobreviventes que reafirmam suas identidades através da escrita.
igrejas inclusivas no Brasil
Authors: Nascimento Mara Regina , Pereira Vinicius Roesler
Published: December 2022

Atualmente a comunidade evangélica corresponde a 31% da população brasileira, ao passo que os indivíduos LGBTQIA+ dizem respeito a 10% dessa mesma população. Conhecidas por seus discursos moralizantes, homofóbicos e em defesa do arranjo tradicional de família, muitas congregações neopentecostais têm gerado tensões de ordem religiosa, social, política e cultural entre essas duas esferas da sociedade. Contudo, é interessante ressaltar que a existência de igrejas que se propõem a acolher a pluralidade das sexualidades e das identidades de gênero também é crescente dentro da vertente neopentecostal. Nossa pesquisa teve como enfoque a comparação entre dois tipos de igrejas evangélicas, as de caráter conservador e as de aspecto progressista/inclusivo, que também possuem, elas próprias, as suas diferenças, como é o caso da ICI e da ICC, a Igreja Cristã Inclusiva e a Igreja Cristã Contemporânea. Interessou-nos problematizar a violência de gênero, as acomodações e as negociações estabelecidas, quando os conflitos ideológicos e a repressão a comportamentos são evidentes.
Experienciando a modernidade
Authors: Videira Edmo
Published: December 2022

O presente trabalho tem como objetivo analisar as configurações da experiência temporal moderna elaboradas pelo autor alemão Georg Simmel (1858-1918) ao longo de sua produção intelectual. Sendo assim, escolhemos o conceito de tragédia da cultura como articulador de nosso enredo, pois ele tangencia os inúmeros elementos da vida moderna que foram narrativizados por Simmel. Tendo como pressuposto a ideia de que a modernidade experienciada pelo autor alemão é permeada por diversas crises e tragédias, nos propomos a realizar um caminho que vai da definição do trágico e seu impacto na cultura moderna europeia até a forma de se experienciar esses fenômenos temporais que, na obra de Simmel, podem ser lidos a partir de suas reflexões sobre o dinheiro e as grandes cidades. Portanto, nossa hipótese é que o conceito simmeliano de trágico bem como a percepção do mesmo nos elementos do cotidiano são sintomas característicos da experiência de nosso autor durante sua existência nesse mundo moderno europeu.
Memória em chamas
Authors: Mazuquieri Reis Lucas Manuel
Published: December 2022

Buscando compreender o impacto das práticas visuais na historicidade contemporânea, esse texto estuda algumas imagens produzidas no Brasil de 2021: as fotografias do incêndio da Cinemateca Brasileira, a obra de net-art Ditamapa, o incêndio da estátua de Borba Gato, a depredação do Escadão Marielle Franco e sua posterior restauração.  Investigamos como os arquivos visuais destes eventos ajudam a pensar os embates entre as políticas de memória que dão forma à nossa condição histórica, considerando que as imagens não apenas representam a experiência vivida, mas são também agentes produtores de experiências no real.
que é história? O que é literatura?
Authors: Dominick LaCapra
Published: December 2022

Ivan Jablonka busca por algo mais do que a simples combinação de história, ciência social e literatura. Ele gostaria que a história – ela própria compreendida como ciência social – fosse uma literatura do mundo real. Ele também se interessa por uma literatura que se orienta não apenas pelos resultados, mas também, de modo mais decisivo, pelas formas de raciocínio e de investigação da história e de outras ciências sociais afins (principalmente, a antropologia e a sociologia). A própria inserção de Jablonka dentro dos Annales parece evidente, principalmente por sua ênfase na cognição, na pesquisa orientada por problemas e no estatuto da história como ciência social. No entanto, as relações entre história, literatura e ficção não receberam muita atenção ou análise por parte dos pesquisadores dentro e ao redor dos Annales e, nesse contexto, Jablonka leva a compreensão da história para direções relativamente pouco exploradas. Apesar de possíveis discordâncias sobre pontos específicos, o livro instigante de Jablonka levanta questões muito relevantes, abre várias linhas significativas de investigação e busca uma interação desejável entre as abordagens históricas e literárias.
AVALIAÇÃO DE BASES GALÊNICAS DESENVOLVIDAS EM UMA FARMÁCIA UNIVERSITÁRIA MAGISTRAL
Authors: Monteiro Mariana Sato de Souza Bustamante , Santos Elisabete Pereira dos , Freitas Zaida Maria Faria de , Nigro Fiammetta , Toma Helena Keiko , Britto Camila Alves
Published: December 2022

As farmácias magistrais dispõem de bases galênicas para a produção de medicamentos tópicos. O creme não iônico e o creme Lanette® são exemplos de bases galênicas muito utilizadas, sendo necessária a sua padronização e o acompanhamento de parâmetros mínimos de qualidade, para garantir um produto estável e homogêneo. Esse trabalho teve como objetivo avaliar as características do creme não iônico e o creme Lanette®, por meio dos testes de viscosidade, densidade, pH, fator de oclusão, espalhabilidade, teste microbiológico, e realizar estudo de estabilidade por meio dos ensaios de pH, viscosidade, densidade e pureza microbiológica 30, 60 e 90 dias após preparo das formulações. O creme não iônico e creme Lanette® se apresentaram semissólidos, inodoros e de coloração branca. O pH das formulações ficaram entre 5,4 e 6,1, compatível com o pH da pele e dentro da faixa recomendada pela Anvisa. As formulações apresentaram densidade acima de 0,85 g/mL, o que é preconizado pela Anvisa. O creme não iônico apresentou um fator de oclusão (F) maior que 50%, favorecendo os efeitos de oclusão e hidratação na pele. Todas as formulações desenvolvidas apresentaram valor de viscosidade entre 1,00 - 1,85 x 103 cP, durante 90 dias após preparo das formulações, a 25 oC e 40 oC. O teste microbiológico mostrou que tanto o creme não iônico quanto o creme Lanette® contendo o conservante, não apresentou crescimento microbiológico por 90 dias após preparo das formulações. As bases galênicas podem ser consideradas estáveis do ponto de vista físico-químico e microbiológico e estão conforme os parâmetros indicados pela Farmacopeia Brasileira.
Study on scheduling and path planning problems of multi-AGVs based on a heuristic algorithm in intelligent manufacturing workshop
Authors: Wang Y.J. , Liu X.Q. , Leng J.Y. , Wang J.J. , Meng Q.N. , Zhou M.J.
Published: December 2022

In order to solve the scheduling and path planning problems of multi-AGVs in an intelligent manufacturing workshop, it is necessary to consider loading, unloading, and transporting the workpiece of each AGV at the same time. A step task scheduling and path optimization mode of AGV is proposed. The process is as follows: Firstly, a mathematical model algorithm and a material transportation task allocation algorithm based on the urgency degree of workpiece processing were established for the optimization objective, and all workpiece transportation task sequences between shelves and processing equipment were assigned to the corresponding AGV to generate the initial feasible path of each AGV. Then, the AGV collision detection and anti-collision algorithm are designed to plan the global collision-free walking path of multi-AGVs in the workshop, and the path can be dynamically adjusted according to the delivery task. The model is solved by a heuristic algorithm ant colony algorithm and MATLAB coding. Finally, an example is given to verify the effectiveness of the method, which can effectively solve the task allocation of multi-AGVs and avoid collision path planning based on the transportation task sequence, and improve the work efficiency of AGV. This research can provide a theoretical basis and practical reference for realizing multi AGVs collaborative scheduling by using AGV automated material transport system in an intelligent production workshop.
Targeting NMDA receptor signaling for therapeutic intervention in brain disorders
Authors: Chen He , Dong Yuanping , Wu Yun , Yi Feng
Published: December 2022

N-Methyl-d-aspartate (NMDA) receptor hyperfunction plays a key role in the pathological processes of depression and neurodegenerative diseases, whereas NMDA receptor hypofunction is implicated in schizophrenia. Considerable efforts have been made to target NMDA receptor function for the therapeutic intervention in those brain disorders. In this mini-review, we first discuss ion flux-dependent NMDA receptor signaling and ion flux-independent NMDA receptor signaling that result from structural rearrangement upon binding of endogenous agonists. Then, we review current strategies for exploring druggable targets of the NMDA receptor signaling and promising future directions, which are poised to result in new therapeutic agents for several brain disorders.
24 Jie Ling Gu (24 Festive Drums): Imagining the 24 Jie Ling (Phenomena) of China in Enacting Cultural Solidarity among the Chinese Diaspora of Malaysia
Authors: Chan Clare Suet Ching
Published: December 2022

The 24 Jie Ling Gu (24 Festive Drums) is a drum ensemble that  consists of 24 lion drums (shigu) played by twenty-four drummers who move to spectacular and dynamic choreography in synchronization with the rhythmic patterns struck on the shigu. It is an “invented tradition” created by the Chinese diaspora of Malaysia. In response to the 1970s National Cultural Policy (NCP) which aimed toward the construction of a homogenized national identity, the Chinese founded the 24 Jie Ling Gu ensemble to enact cultural solidarity and unify the people toward a sense of belonging to their distant motherland in China. They created the music and movements of the 24 Jie Ling Gu to manifest the 24 jie ling (phenomena)—the weather changes, agricultural activities, and natural phenomenon inherent in the 24 jie qi (jie: joints; qi: breath) or seasonal periods. Due to the fact that the Chinese of Malaysia have not physically experienced China but are connected to it through literature and media technology, I argue that the 24 Jie Ling Gu performers utilized their imagination and localized experience of Malaysia to manifest the 24 jie ling in China. This article is based on ethnographic fieldwork and ongoing revisits to this genre through a span of more than 20 years.
Development of Physics Demonstration Videos on Youtube (PDVY) as Physics Learning Media
Authors: Irvani A I , Warliani R
Published: December 2022

The availability of physics demonstration videos relevant to curriculum needs is still limited. The aims of this study were (1) to develop physics learning media in the form of demonstration videos; (2) testing the feasibility of using demonstration videos as a medium for learning physics; and (3) knowing student responses to demonstration videos. The name of this demonstration video is Physics Demonstration Videos on YouTube (PDVY). This video is available on the PDVY Indonesia YouTube channel with open access. This research uses research and development methods. The steps for making this demonstration video consist of analyzing the core standards and competency standards of physics subjects, designing storyboards, taking pictures, editing, initial testing, revising initial test results, field trials and revising the results of field trials. The trial was conducted on 129 high school students in Garut, Indonesia. The results showed that (1) the physics demonstration video was composed with input from the validator, two physics lecturers, and two physics teachers; (2) the demonstration video is suitable for use as a physics learning medium from the material and media aspects; and (3) excellent response from high school students and teachers. Based on the validation of both the content validator and the media validator, it shows that the design of the parabolic motion demonstration video is very valid. The benefit aspect gets the highest score. This shows that the video developed has a high use value in the learning process.
Confronting Educational Challenges and Reshaping Future Education
Authors: Zhou Longjun
Published: December 2022

Education is more complicated and difficult than many other human activities because it involves the complexity and diversity of mankind. For centuries, numerous educational practitioners and researchers have devoted themselves to the exploration of educational practice and theories and have achieved remarkable accomplishments. However, humans are still plagued by a multitude of educational complications.
Prospective evaluation of the effectiveness of colonoscopic polyp resection
Authors: Paez Loyná , Cury Marcelo , Sawhney Mandeep , Elias Geraldo , Costa Borges Alana , Nakao Frank
Published: December 2022

Background: Colon cancer incidence is on the rise and despite having undergone a colonoscopy to screen and remove all visible polyps as a preventive measure, nearly 1 in 110 patients will develop colon cancer within 3 years. The three main possible explanations for this are missing polyps, incompletely removed polyps, or rapidly growing tumors. Objective: To determine the proportion of colonic polyps ≤ 3 cm in size that show evidence of residual polyp tissue following colonoscopy and polypectomy. Methods: Patients who presented for colonoscopy at a community center were invited to participate in this study. Those who had confirmed adenoma were invited to repeat the procedure in 2 to 6 months with biopsies at the resection site to check for the presence of residual polyp tissue. Exclusion criteria included the absence of adenoma in the resected lesion, contraindication to polypectomy or follow-up colonoscopy, refusal to participate in follow-up examination, and other conditions increasing colon cancer risk. If polyps between 5 mm and 30 mm were found, the endoscopist resected them using the hot snare polypectomy technique or endoscopic mucosal resection (EMR). Results: Ninety-one patients completed the study protocol, with 105 lesions being studied. The second procedure was performed between 2 and 24 months. All analyzed lesions were adenoma, and three of them were associated with intramucosal adenocarcinoma. Others included 60 tubular lesions, 37 tubulovillous lesions, and 5 serrated lesions. Thirty-two lesions were flat and were removed by EMR; polypectomy was performed for 73 lesions. There was no residual tissue in the polypectomy group. The EMR group presented three cases of incomplete resection without adenocarcinomas. Conclusion: Our study showed that flat lesions might be an important cause of incomplete resection. In addition, we documented the complete resection of pedunculated lesions in all studied patients. This study provides more evidence to validate the empirical perception in the medical field that assumes the complete resection of pedunculated polyps. Therefore, we suggest that patients who undergo snare removal of pedunculated polyps should follow the regular protocol for colon cancer screening, with colonoscopy every 5 to 10 years. Meanwhile, the surveillance scheme should be reviewed for patients who undergo removal of flat lesions smaller than 30 mm.
Seroprevalence of cytomegalovirus antibodies among aborted women in Ibb city-Yemen
Authors: Baset Abbas Abdul , AL-Moliki Saba , Al-Zafri Jalila , Al-Fadag Ghadah , Anada AlAmrani Qatar , Al-Nuzily Ashwaq , AL-Bokhiti Alia , Almezgagi Maged , Al-Samman Ali
Published: December 2022

Abortion is one of the most common health problems in the world, its causes vary, and some of them are viral. Cytomegalovirus (CMV) is one of the causes of abortion. So, this study aims to investigate the seroprevalence of CMV antibodies among aborted women. This study was a cross-sectional study conducted in Ibb city-Yemen. Serum samples were collected between September 2021 to April 2022. The serum samples were analyzed for IgG and IgM antibodies to CMV by Electro-Chemiluminescence Immunoassay (ECLIA). Overall, 150 aborted women were enrolled. Amongst these cases, 148 out of 150 (98.67%) were positive for CMV IgG antibodies. Additionally, 11 out of 150 (7.33%) of the samples were positive for CMV IgM antibodies. The CMV IgG seroprevalence was not significantly influenced by age, residence, education level, socioeconomic status and abortion time. In addition, the CMV IgM seroprevalence was significantly associated with education level, socioeconomic status and abortion time. In conclusion, the low rate of CMV IgM and a high proportion of CMV IgG for most major of abortion women in this study suggest that CMV may not be the common factor leading to abortion.
Practical application of high-performance liquid chromatography and high-performance thin-layer chromatography in pharmaceutical analysis.
Authors:   A. V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, Yegorova A. , Scrypynets Yu ,   A.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, Fedosenko G ,   InterChem SLC, Maltsev G ,   InterChem SLC, Kashutskiy S
Published: December 2022

Currently, chromatographic methods are widely used to control the quality of products in the pharmaceutical and food industries. This article is devoted to the systematization of the results of scientific research of the authors on the development, validation and application of a number of chromatographic methods in the creation of generic drugs, as well as in the analysis of medicinal plant materials. The developed methods are validated according to the following parameters: specificity, linearity, accuracy and limit of detection. The specificity of the methods is based on the ability to evaluate the analyte in the presence of other components and is confirmed by using external standards. The accuracy was assessed by the results of the analysis of different weights or by the "added-found" method. For the developed methods, parameters of the suitability of chromatographic systems were established (peak symmetry factor, number of theoretical plates, relative standard deviation of retention time and peak area).
Women, Peace, and Conflict; Increasing The Capability and Number of Indonesian Women Peacekeepers in the United Nations Interim Force in Lebanon (UNIFIL)
Authors: Masyrofah Masyrofah , Lubis Amany
Published: December 2022

This article analyses increasing the capability and number of Indonesian women's participation in the UNIFIL (United Nations Interim Force in Lebanon) and the approaches and strategies women peacekeepers used while on duty at UNIFIL. Based on Presidential Regulation No. 18/2014 concerning the protection and empowerment of women and children in social conflicts, in contrast to the fact that women's involvement in carrying out UNIFIL's peacekeeping mission is still weak, even though women have great potential in soft power. Women have different approaches to seeking peace between the two parties involved in the conflict or keeping the peace from disappearing. This research is qualitative with a statutory approach, peacebuilding, conflict resolution, international law, and politics—data collection techniques through interviews and literature studies. These study findings are evidence of Indonesia's success in world peace missions. Women peacekeepers in the Indonesian National Armed Forces have a role that cannot be replaced by other elements, considering the conflict field prioritizes the unique skills of the Women's Indonesian National Armed Forces and Women's Police. Apart from that, the unique socio-religious-cultural characteristics in the South Lebanese Region have a reasonably complex composition, including interfaith and intra-faith sensitivity, Sunni-Shi'a dimensions, and the Druze sect. The readiness of Indonesian women peacekeepers is in good condition and continues to increase the skill and strategy to keep peace worldwide. The potential of Indonesian women peacekeepers is an integral part of the Indonesian National Armed Force's mission. Namely, the ability for territorial development is a distinctive characteristic of the Indonesian National Armed Forces as a national army born in conditions of struggle. Its operational capabilities are closely related to raising support from the community in its area of operation.