bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a life expectancy table for individuals with type 1 diabetes
Authors: Tran-Duy An , Knight Josh , Clarke Philip M. , Svensson Ann-Marie , Eliasson Björn , Palmer Andrew J.
Published: July 2021

Aims/hypothesis

Tables reporting life expectancies by common risk factors are available for individuals with type 2 diabetes; however, there is currently no published equivalent for individuals with type 1 diabetes. We aimed to develop a life expectancy table using a recently published simulation model for individuals with type 1 diabetes.

Methods

The simulation model was developed using data from a real-world population of patients with type 1 diabetes selected from the Swedish National Diabetes Register. The following six important risk factors were included in the life table: sex; age; current smoking status; BMI; eGFR; and HbA1c. For each of 1024 cells in the life expectancy table, a synthetic cohort containing 1000 individuals was created, with other risk factors assigned values representative of the real-world population. The simulations were executed for all synthetic cohorts and life expectancy for each cell was calculated as mean survival time of the individuals in the respective cohort.

Results

There was a substantial variation in life expectancy across patients with different risk factor levels. Life expectancy of 20-year-old men varied from 29.3 years to 50.6 years, constituting a gap of 21.3 years between those with worst and best risk factor levels. In 20-year-old women, this gap was 18.9 years (life expectancy range 35.0–53.9 years). The variation in life expectancy was a function of the combination of risk factor values, with HbA1c and eGFR consistently showing a negative and positive correlation, respectively, with life expectancy at any level combination of other risk factors. Individuals with the lowest level (20 kg/m2) and highest level of BMI (35 kg/m2) had a lower life expectancy compared with those with a BMI of 25 kg/m2. Non-smokers and women had a higher life expectancy than smokers and men, respectively, with the difference in life expectancy ranging from 0.4 years to 2.7 years between non-smokers and smokers, and from 1.9 years to 5.9 years between women and men, depending on levels of other risk factors.

Conclusions/interpretation

The life expectancy table generated in this study shows a substantial variation in life expectancy across individuals with different modifiable risk factors. The table allows for rapid communications of risk in an easily understood format between healthcare professionals, health economists, researchers, policy makers and patients. Particularly, it supports clinicians in their discussion with patients about the benefits of improving risk factors.

Graphical abstract
Lesser spot-nosed monkeys coordinate alarm call production with associated Campbell’s monkeys
Authors: Le Floch Auriane , Bouchard Alice , Gallot Quentin , Zuberbühler Klaus
Published: July 2021

Forest monkeys often form semi-permanent mixed-species associations to increase group-size related anti-predator benefits without corresponding increases in resource competition. In this study, we analysed the alarm call system of lesser spot-nosed monkeys, a primate that spends most of its time in mixed-species groups while occupying the lowest and presumably most dangerous part of the forest canopy. In contrast to other primate species, we found no evidence for predator-specific alarm calls. Instead, males gave one general alarm call type (‘kroo’) to three main dangers (i.e., crowned eagles, leopards and falling trees) and a second call type (‘tcha-kow’) as a coordinated response to calls produced in non-predatory contexts (‘boom’) by associated male Campbell’s monkeys. Production of ‘kroo’ calls was also strongly affected by the alarm calling behaviour of male Campbell’s monkeys, suggesting that male lesser spot-nosed monkeys adjust their alarm call production to another species’ vocal behaviour. We discuss different hypotheses for this unusual phenomenon and propose that high predation pressure can lead to reliance on other species vocal behaviour to minimise predation.

Significance statement

Predation can lead to the evolution of acoustically distinct, predator-specific alarm calls. However, there are occasional reports of species lacking such abilities, despite diverse predation pressure, suggesting that evolutionary mechanisms are more complex. We conducted field experiments to systematically describe the alarm calling behaviour of lesser spot-nosed monkeys, an arboreal primate living in the lower forest strata where pressure from different predators is high. We found evidence for two acoustically distinct calls but, contrary to other primates in the same habitat, no evidence for predator-specific alarms. Instead, callers produced one alarm call type (‘kroo’) to all predator classes and another call type (‘tcha-kow’) to non-predatory dangers, but only as a response to a specific vocalisation of Campbell’s monkeys (‘boom’). The production of both calls was affected by the calling behaviour of Campbell’s monkeys, suggesting that lesser spot-nosed monkey vocal behaviour is dependent on the antipredator behaviour of other species. Our study advances the theory of interspecies interactions and evolution of alarm calls.
Keratin 7 expression in hepatic cholestatic diseases
Authors: Sakellariou S. , Michaelides C. , Voulgaris T. , Vlachogiannakos J. , Manesis E. , Tiniakos D. G. , Delladetsima I.
Published: July 2021

We evaluated keratin 7 (K7) hepatocellular expression in 92 patients with common types of acute and chronic cholestatic diseases caused by bile duct obstruction/destruction or parenchymal lesions [acute hepatitis (n=20), mixed/pure cholestasis (n=16), primary biliary cholangitis-PBC (n=35), primary sclerosing cholangitis-PSC (n=10), vanishing bile duct syndrome (n=3), complete large bile duct obstruction due to space-occupying lesions (n=8)]. K7 immunohistochemical hepatocellular expression and ductular reaction (DR) were semi-quantitatively assessed. Results were correlated with liver enzyme serum levels, cholestasis type, histological features, hepatocellular Ki67 labelling index (LI) and HepPar1 expression. Hepatocellular K7 expression was detected in 87% (81/92) cases and in all cholestatic disease types with lowest incidence in pure/mixed cholestasis and highest in incomplete bile duct obstruction (iBDO), reaching 100% in PSC. K7-positive hepatocytes had low Ki67 LI (0-5%) retaining HepPar1 expression, irrespective of disease type. PSC cases had high K7 hepatocellular expression even with intact bile ducts, a feature that may aid differential diagnosis of cholestatic syndromes. K7 hepatocellular expression significantly correlated with cholestasis type, bile duct loss and fibrosis stage. It was higher in milder acute cholestatic hepatitis showing inverse correlation with hepatocyte proliferation and serum transaminase levels. In iBDO, younger age independently correlated with high K7 expression, while serum GGT levels showed a nearly significant correlation. Correlation with DR findings implied that K7-positive hepatocytes may result through metaplasia. In conclusion, K7 hepatocellular expression is a sensitive though non-specific marker of cholestasis. It may represent a cytoprotective reaction of resting hepatocytes in cholestasis of longer duration especially in younger patients.
The expression of tenascin-C in neural stem/progenitor cells is stimulated by the growth factors EGF and FGF-2, but not by TGFβ1
Authors: Theocharidis Ursula , Roll Lars , Faissner Andreas
Published: July 2021

Neural stem/progenitor cells (NSPCs) rely on internal and external cues determining their lineage decisions during brain development. The progenitor cells of the embryonic mammalian forebrain reside in the ventricular and subventricular zones of the lateral ventricles, where they proliferate, generate neurons and glial cells, and respond to external cues like growth factors. The extracellular matrix (ECM) surrounds NSPCs and influences the cell fate by providing mechanical scaffold, trophic support, and instructive signals. The ECM molecule tenascin-C (Tnc) is expressed in the proliferative zones of the developing forebrain and involved in the proliferation and maturation of NSPCs. Here, we analyzed the regulation of the Tnc gene expression by NSPCs cultivated under the influence of different growth factors. We observed that the epidermal growth factor (EGF) and the fibroblast growth factor (FGF)-2 strongly increased the expression of Tnc, whereas the transforming growth factor (TGF)β 1 had no effect on Tnc gene expression, in contrast to previous findings in cell cultures of neural and non-neural origin. The stimulation of the Tnc gene expression induced by EGF or FGF-2 was reversible and seen in constantly treated as well as short term stimulated NSPC cultures. The activation depended on the presence of the respective receptors, which was slightly different in cortical and striatal NSPC cultures. Our results confirm the influence of extracellular stimuli regulating the expression of factors that form a niche for NSPCs during embryonic forebrain development.
Genotypic traits and tradeoffs of fast growth in silver birch, a pioneer tree
Authors: Mikola Juha , Koikkalainen Katariina , Rasehorn Mira , Silfver Tarja , Paaso Ulla , Rousi Matti
Published: July 2021

Fast-growing and slow-growing plant species are suggested to show integrated economics spectrums and the tradeoffs of fast growth are predicted to emerge as susceptibility to herbivory and resource competition. We tested if these predictions also hold for fast-growing and slow-growing genotypes within a silver birch, Betula pendula population. We exposed cloned saplings of 17 genotypes with slow, medium or fast height growth to reduced insect herbivory, using an insecticide, and to increasing resource competition, using naturally varying field plot grass cover. We measured shoot and root growth, ectomycorrhizal (EM) fungal production using ergosterol analysis and soil N transfer to leaves using 15N-labelled pulse of NH4+. We found that fast-growing genotypes grew on average 78% faster, produced 56% and 16% more leaf mass and ergosterol, and showed 78% higher leaf N uptake than slow-growing genotypes. The insecticide decreased leaf damage by 83% and increased shoot growth, leaf growth and leaf N uptake by 38%, 52% and 76%, without differences between the responses of fast-growing and slow-growing genotypes, whereas root mass decreased with increasing grass cover. Shoot and leaf growth of fast-growing genotypes decreased and EM fungal production of slow-growing genotypes increased with increasing grass cover. Our results suggest that fast growth is genotypically associated with higher allocation to EM fungi, better soil N capture and greater leaf production, and that the tradeoff of fast growth is sensitivity to competition, but not to insect herbivory. EM fungi may have a dual role: to support growth of fast-growing genotypes under low grass competition and to maintain growth of slow-growing genotypes under intensifying competition.
Nonlinear multiscale simulation of elastic beam lattices with anisotropic homogenized constitutive models based on artificial neural networks
Authors: Gärtner Til , Fernández Mauricio , Weeger Oliver
Published: July 2021

A sequential nonlinear multiscale method for the simulation of elastic metamaterials subject to large deformations and instabilities is proposed. For the finite strain homogenization of cubic beam lattice unit cells, a stochastic perturbation approach is applied to induce buckling. Then, three variants of anisotropic effective constitutive models built upon artificial neural networks are trained on the homogenization data and investigated: one is hyperelastic and fulfills the material symmetry conditions by construction, while the other two are hyperelastic and elastic, respectively, and approximate the material symmetry through data augmentation based on strain energy densities and stresses. Finally, macroscopic nonlinear finite element simulations are conducted and compared to fully resolved simulations of a lattice structure. The good agreement between both approaches in tension and compression scenarios shows that the sequential multiscale approach based on anisotropic constitutive models can accurately reproduce the highly nonlinear behavior of buckling-driven 3D metamaterials at lesser computational effort.
Tracking mineral and geochemical characteristics of Holocene lake sediments: the case of Hotagen, west-central Sweden
Authors: Kanbar Hussein Jaafar , Tran Le Thai , Olajos Fredrik , Englund Göran , Holmboe Michael
Published: July 2021

Purpose

Intact lake sediments reflect the development of terrestrial ecosystems. This development can be understood by decoding mineral and geochemical information of sedimentary archives. Therefore, we characterized a Holocene lake sediment core and revealed bulk to micro-scale variations via a combination of geochemical techniques and statistical methods.

Methods

A 2.3 m sediment core was collected from Hotagen, a lake in west-central Sweden; a sediment sample was collected every 5 cm. A part of each sediment sample was kept untreated (named bulk) and another part was size-fractionated into < 4, 4–16, 16–64, and > 64 µm subsamples. Characterization was then made with respect to grain size distribution (GSD), physico-chemical parameters, geochemical properties, organic composition, and mineralogy. The sediments were investigated at bulk, micro-, and elemental scales using powder X-ray diffraction (XRD), diffuse reflectance infrared Fourier transform spectroscopy (DRIFT), and scanning electron microscopy coupled to energy-dispersive X-ray spectroscopy (SEM–EDX).

Results

The deepest sediment was identified as glacial till dating back to the Late Pleistocene. The bulk sediments showed a clear distinction between 0–195 cm (unit 1, U1) and 200–225 cm (unit 2, U2) depths. Quartz and feldspar minerals decreased and organic matter and clay minerals increased from the till towards the lower limit of U1. The development in the sedimentary properties marked the transformation of the terrestrial ecosystem from glacier-covered land to vegetated areas. This development was also well reflected by the appearance of X-ray amorphous materials and the formation of distinct organo-mineral aggregates; chlorite was the predominant clay mineral in these aggregates. The geochemical variation between U2 and U1 sediments was further established by resolving the DRIFT spectral components through multivariate curve resolution alternating least square (MCR-ALS). The U1 sediments settled over a period of ~ 7500 years and showed comparable mineral, geochemical, and organic composition. However, the size-fractionated sediments, mainly < 4 µm, showed diverse mineral and geochemical composition. Indeed, these sediments were distinct by containing relatively higher amounts of X-ray amorphous materials and clay minerals, the latter had variable Na, Mg, and K contents.

Conclusion

The combined use of geochemical and statistical approaches used in this study followed the mineral and geochemical development of sediments that had settled during the Late Pleistocene and Early Holocene Epochs. Finally, the U2 sediments marked the terrestrial ecosystem development that occurred during the late glaciation, deglaciation, and post-glaciation periods.

Graphical abstract
Selbsthilfe und Gesundheitskompetenz während der Corona-Pandemie: Ergebnisse der qualitativen GeMSeHeCo-Studie
Authors: Kogel Lisa Marie , Steeb Natalie , Rathmann Katharina
Published: July 2021

Hintergrund

Die Pandemie stellt Menschen mit Beeinträchtigung vor vielfältige Herausforderungen, insbesondere auch beim Umgang mit Gesundheitsinformationen. Bislang ist nur wenig über die Rolle der Selbsthilfe bei der Förderung der Gesundheitskompetenz ihrer Mitglieder während der Pandemie bekannt.

Methodik

Der Studie „Gesundheitskompetenz von Mitgliedern der Selbsthilfe: Herausforderungen durch die Corona-Pandemie (GeMSeHeCo)“ liegt ein qualitatives Studiendesign zugrunde. Der Feldzugang erfolgte deutschlandweit über die Selbsthilfegruppen. Von Juli bis Oktober 2020 wurdenN = 19 Telefoninterviews mit Vertreter*innen von Selbsthilfegruppen durchgeführt, transkribiert und inhaltsanalytisch ausgewertet.

Ergebnisse

Vertreter*innen der Selbsthilfe berichteten über Stärken und Schwächen der Mitglieder im Umgang mit Gesundheitsinformationen während der Corona-Pandemie. Schwächen wurden v. a. bei älteren Mitgliedern, Menschen mit niedrigem Bildungsniveau und mit Migrationshintergrund berichtet. Stärken beobachteten die Vertreter*innen bei langjährigen Mitgliedern und bei Mitgliedern, die sich zu ihrer Krankheit kontinuierlich weiterbilden.

Diskussion

Die Selbsthilfe wird während der Pandemie als wichtige Unterstützung der Mitglieder im Umgang mit Gesundheitsinformationen wahrgenommen. Ein Vorteil für die Mitglieder besteht insbesondere in der Prüfung und Zusammenstellung von Gesundheitsinformationen nach individuellen Bedarfen durch die Selbsthilfe. Herausforderungen können aufgrund von Sprach- und Verständnisschwierigkeiten entstehen, bspw. durch einen Migrationshintergrund. Der Ausbau von digitalen Angeboten hat sich in dieser Zeit als hilfreich erwiesen. Dabei sollte die Unterstützung vermehrt Ältere und Mitglieder mit geringen finanziellen Möglichkeiten berücksichtigen, da diese während der Pandemie weniger Zugang zu digitalen Angeboten aufweisen.
Multistep batch-flow hybrid synthesis of a terbinafine precursor
Authors: Hergert Tamás , Mátravölgyi Béla , Örkényi Róbert , Éles János , Faigl Ferenc
Published: July 2021

A three-step batch-flow hybrid process has been developed for an expeditious synthesis of the enynol key intermediate of antifungal terbinafine. This procedure involves consecutive organometallic steps without the necessity of any in-line purification: after a metalation by n-butyllithium, a selective addition of the lithium salt was elaborated followed by a Grignard reaction resulting in a high yield of 6,6-dimethylhept-1-en-4-yn-3-ol. Moreover, as an alternative to tetrahydrofuran, cyclopentyl methyl ether was used as solvent implementing a safe, sustainable, yet selective synthetic process. Even on a laboratory-scale, the optimized batch-flow hybrid process had a theoretical throughput of 41 g/h. Furthermore, the newly developed process provides an efficient synthesis route to the key-intermediate, while making acrolein obsolete, minimizing side-products, and enabling safe and convenient scale-up.
Is a PD game still a dilemma for Japanese rural villagers? A field and laboratory comparison of the impact of social group membership on cooperation
Authors: Mitani Yohei
Published: July 2021

Local norms and shared beliefs in cohesive social groups regulate individual behavior in everyday economic life. I use a door-to-door field experiment where a hundred and twenty villagers recruited from twenty-three communities in a Japanese rural mountainous village play a simultaneous prisoner’s dilemma game. To examine whether a set of experiences shared through interactions among community members affect experimental behavior, I compare villagers’ behavior under in-community and out-community random matching protocols. I also report a counterpart laboratory experiment with seventy-two university student subjects to address the external validity of laboratory experiments. The findings are three-fold. First, almost full cooperation is achieved when villagers play a prisoner’s dilemma game with their anonymous community members. Second, cooperation is significantly higher within the in-group compared to the out-group treatment in both the laboratory and field experiments. Third, although a significant treatment effect of social group membership is preserved, a big difference in the average cooperation rates is observed between the laboratory and field.
HANDLING DISTRUST ON RISK COMMUNICATION IN NIGERIA: A STRATEGY TO STRENGTHENING THE COVID-19 OUTBREAK RESPONSE
Authors: Ilesanmi Olayinka Stephen , Akosile Priscilla Onaopemipo , Afolabi Aanuoluwapo Adeyimika , Ukwenya Victor Okoliko
Published: July 2021

Background

This study aimed to assess the level of trust in the COVID-19 risk communication efforts in Nigeria.

Methods

We conducted a descriptive cross-sectional study among community members aged 15 years and above in Ondo state in October, 2020. Data were collected using an interviewer-administered questionnaire. Data were analyzed using SPSS version 22. Descriptive statistics were summarized using frequencies. Trust was ranked from “1” implying “Low level of trust” to “7” denoting “High level of trust”. We conducted bivariate Chi-square test on respondents’ level of trust in the Nigeria Centre for Disease Control (NCDC) and socio-demographic characteristics. The level of significance was set at p<0.05.

Results

Among the 691 respondents, 244 (35.3%) were aged 21 to 29 years, and 304 (51.4%) used the NCDC to obtain COVID-19 knowledge. Overall, 205 (41.8%) had high level of trust in the NCDC. Furthermore, 51 (51.5%) individuals aged 30-39 years had high level of trust in the NCDC (ᵡ2=17.455, p= 0.001). Also, 114 (48.5%) persons who lived with children below 18 years had high level of trust in the NCDC (ᵡ2= 8.266, p= 0.004).

Conclusion

Policy makers should prioritize the involvement of young and educated persons in COVID-19 risk communication strategies.
Risk factors and outcomes associated with community-onset and hospital-acquired coinfection in patients hospitalized for coronavirus disease 2019 (COVID-19): A multihospital cohort study
Authors: Petty Lindsay A. , Flanders Scott A. , Vaughn Valerie M. , Ratz David , O’Malley Megan , Malani Anurag N. , Washer Laraine , Kim Tae , Kocher Keith E. , Kaatz Scott , Czilok Tawny , McLaughlin Elizabeth , Prescott Hallie C. , Chopra Vineet , Gandhi Tejal
Published: July 2021

Background:

We sought to determine the incidence of community-onset and hospital-acquired coinfection in patients hospitalized with coronavirus disease 2019 (COVID-19) and to evaluate associated predictors and outcomes.

Methods:

In this multicenter retrospective cohort study of patients hospitalized for COVID-19 from March 2020 to August 2020 across 38 Michigan hospitals, we assessed prevalence, predictors, and outcomes of community-onset and hospital-acquired coinfections. In-hospital and 60-day mortality, readmission, discharge to long-term care facility (LTCF), and mechanical ventilation duration were assessed for patients with versus without coinfection.

Results:

Of 2,205 patients with COVID-19, 141 (6.4%) had a coinfection: 3.0% community onset and 3.4% hospital acquired. Of patients without coinfection, 64.9% received antibiotics. Community-onset coinfection predictors included admission from an LTCF (OR, 3.98; 95% CI, 2.34–6.76; P < .001) and admission to intensive care (OR, 4.34; 95% CI, 2.87–6.55; P < .001). Hospital-acquired coinfection predictors included fever (OR, 2.46; 95% CI, 1.15–5.27; P = .02) and advanced respiratory support (OR, 40.72; 95% CI, 13.49–122.93; P < .001). Patients with (vs without) community-onset coinfection had longer mechanical ventilation (OR, 3.31; 95% CI, 1.67–6.56; P = .001) and higher in-hospital mortality (OR, 1.90; 95% CI, 1.06–3.40; P = .03) and 60-day mortality (OR, 1.86; 95% CI, 1.05–3.29; P = .03). Patients with (vs without) hospital-acquired coinfection had higher discharge to LTCF (OR, 8.48; 95% CI, 3.30–21.76; P < .001), in-hospital mortality (OR, 4.17; 95% CI, 2.37–7.33; P ≤ .001), and 60-day mortality (OR, 3.66; 95% CI, 2.11–6.33; P ≤ .001).

Conclusion:

Despite community-onset and hospital-acquired coinfection being uncommon, most patients hospitalized with COVID-19 received antibiotics. Admission from LTCF and to ICU were associated with increased risk of community-onset coinfection. Future studies should prospectively validate predictors of COVID-19 coinfection to facilitate the reduction of antibiotic use.
“The Band of Brothers”: The Mobilization of English Welsh Dual Identities in Second World War Britain
Authors: Ugolini Wendy
Published: July 2021

In the run-up to the Second World War, the War Office agreed to organize territorial units that recruited specifically on the grounds of English Welsh dual identities. These formations, which comprised the 99th London Welsh Heavy Anti-Aircraft regiment and the 46th Liverpool Welsh Royal Tank Regiment, began recruiting in 1939 from English cities with significant Welsh populations. This article explores the mobilization and performance of English Welsh identities during the Second World War and reflects upon why, at a time of global conflict, some English men opted to enlist on the basis of Welsh antecedents. Relatively little attention has been paid to the plurality of British identity in wartime or to how the existence of what historian Thomas Hajkowski has called “hybrid ‘dual identities’” within the constituent countries of the United Kingdom informed the functioning of Britishness during the Second World War. Making use of previously unpublished and original life-writing sources, this article illuminates the significance of dual identifications across two nations at once—in this case, Wales and England—within the multinational state of Britain at war. Overall, by examining the intersectionality between subjective wartime constructions of kin, home, and nation(s), it points to how a sense of dual identifications could feed into recruitment patterns and potentially bolster combat motivation and morale. By highlighting the interconnectedness between constituent nations of Britain, and the complexities of identity formation within Britishness, this article adds to the literature that complicates the notion of fixed singular national identities and underscores the importance of dual identifications within and across the borders of the constituent nations in advancing our understanding of twentieth-century Britain.
Self-control and cooperation in childhood as antecedents of less moral disengagement in adolescence
Authors: Gülseven Zehra , Yu Mark Vincent B. , Zarrett Nicole , Vandell Deborah Lowe , Simpkins Sandra D.
Published: July 2021

Moral disengagement is a social cognition people use to engage in wrongdoings even when they know it is wrong. However, little is known about the antecedents that predict moral disengagement. The current study focuses on the development of self-control and cooperation during middle childhood as two antecedents of moral disengagement among 1,103 children (50% female; 77% White, 12% Black, 6% Hispanic, and 5% other). Children's self-control at age 8 and growth in self-control from age 8 to 11 were positively linked to adolescents seeing themselves as having self-control at age 15, which then predicted less moral disengagement at age 18. Children's cooperation at age 8 also was positively linked to adolescents’ self-views of cooperation at age 15, which in turn, was associated with less moral disengagement at age 18. These findings demonstrate the potential of self-control and cooperation as intrapersonal and interpersonal strengths during middle childhood for mitigating moral disengagement 10 years later.
A new bath complex in Late Roman Dyrrachium (Albania)
Authors: Shkodra-Rrugia Brikena
Published: July 2021

This note considers a Late Roman bath building recently discovered in Durrës, Albania (ancient Dyrrachium), near the presumed Roman city center. This discovery is particularly interesting given our limited knowledge of the urban layout and of bathhouses during this important phase of the city. Despite the limited scope of the excavations, the layout of the complex, as well as certain architectural characteristics, suggests the use of design principles based on Imperial baths. The exclusive use of bricks is significant for this area in Late Antiquity. The imposing monumentality of the structures is comparable to baths in cities with Imperial authority. In the absence of stratified layers linked to this structure, moldmade marks on the bricks and decorative features from the marble facing provide a chronological window between the last quarter of the 4th c. and around the middle of the 5th c. CE for its construction.
Feeding outcomes in post-discharge feeding clinic for infants following cardiac surgery
Authors: Jones Courtney , Winder Melissa , Ou Zhining , Miller Thomas A. , Malik Lauren , Flannery Moira , Glotzbach Kristi
Published: July 2021

Introduction:

The aim of this study was to describe the development and assess the usefulness of a feeding clinic to help infants with CHD tolerate the highest level of oral feeding while achieving growth velocity and supporting neurodevelopment.

Materials and methods:

This retrospective, cohort study assessed feeding outcomes for infants who underwent cardiac surgery at <30 days of age with cardiopulmonary bypass between February 2016 and April 2020. Diagnoses, age at surgery, hospitalisation variables, and feeding outcomes were compared between two cohorts, pre- and post-implementation of a specialised feeding clinic using Exact Wilcoxon signed-rank test, chi-squared, or Fisher’s exact test. The association between time to full oral feed and risk factors was assessed using univariable and multivariable Cox regression model.

Results:

Post-clinic infants (n = 116) surgery was performed at a median of 6 days of life (interquartile range: 4, 8) with median hospital length of stay of 19 days (interquartile range: 16, 26). Infants’ median age at first clinic visit was at 30 days old (interquartile range: 24, 40) and took median 10 days (interquartile range: 7, 12) after hospital discharge to first clinic visit. In the post-clinic cohort, the median time to 100% oral feeding was 47 days (interquartile range: 27, 96) compared to the 60 days (interquartile range: 20, 84) in the pre-clinic cohort (n = 22), but the difference was not statistically significant.

Discussion:

The cardiac feeding clinic was utilised by our neonatal surgery population and feasible in coordination with cardiology follow-up visits. Future assessment of cardiac feeding clinic impact should include additional measures of feeding and neurodevelopmental success.
Total anomalous origin of the coronary arteries from the pulmonary artery: a systematic review
Authors: Guenther Timothy M. , Chen Sarah A. , Gustafson Joshua D. , Ing Frank F. , Brothers Julie A. , Raff Gary W.
Published: July 2021

Background:

Although rare, coronary artery anomalies can have significant clinical implications. Total anomalous origin of the coronary arteries from the pulmonary artery (TCAPA) represents a rare subtype of coronary artery anomaly for which little is known. The aim of this review was to characterise the presentation, utilised diagnostic modalities, associated cardiac lesions, and treatment strategies in patients with TCAPA.

Methods:

A systematic review was performed for cases of TCAPA using PubMed, Embase, and Web of Science. Keywords searched included “total anomalous origin of the coronary arteries from the pulmonary artery,” “single ostium anomalous coronary artery from the pulmonary artery,” and “anomalous origin of both coronary arteries from the pulmonary artery.”

Results:

Fifty-seven cases of TCAPA were identified in 50 manuscripts. Fifty-eight per cent of patients were male and the median age at presentation was 10 days (mean 1.71 ± 6.6 years, range 0 days–39 years). Most patients were symptomatic at the time of presentation; cyanosis (n = 22) and respiratory distress (n = 14) were the most common symptoms. Cases were most commonly diagnosed at autopsy (n = 26, 45.6%), but operative intervention was pursued in 22 cases (45.6%); aortic re-implantation (n = 14) and a Takeuchi-type repair (n = 7) were the most common routes of repair.

Conclusions:

The clinical presentation of patients with TCAPA was found to be variable, likely related to the presence of associated cardiac lesions. TCAPA should be considered in patients with suspected anomalous origin of the left coronary artery from the pulmonary artery for the serious consequences that can occur if not promptly corrected.
Comparative Effects of Physical Exercise and Other Behavioral Interventions on Functional Status Outcomes in Mild Cognitive Impairment
Authors: Shandera-Ochsner Anne L. , Chandler Melanie J. , Locke Dona E. , Ball Colleen T. , Crook Julia E. , Phatak Vaishali S. , Smith Glenn E.
Published: July 2021

Objectives:

Lifestyle modifications for those with mild cognitive impairment (MCI) may promote functional stability, lesson disease severity, and improve well-being outcomes such as quality of life. The current analysis of our larger comparative effectiveness study evaluated which specific combinations of lifestyle modifications offered as part of the Mayo Clinic Healthy Action to Benefit Independence in Thinking (HABIT) program contributed to the least functional decline in people with MCI (pwMCI) over 18 months.

Methods:

We undertook to compare evidence-based interventions with one another rather than to a no-treatment control group. The interventions were five behavioral treatments: computerized cognitive training (CCT), yoga, Memory Support System (MSS) training, peer support group (SG), and wellness education (WE), each delivered to both pwMCI and care partners, in a group-based program. To compare interventions, we randomly withheld one of the five HABIT® interventions in each of the group sessions. We conducted 24 group sessions with between 8 and 20 pwMCI–partner dyads in a session.

Results:

Withholding yoga led to the greatest declines in functional ability as measured by the Functional Activities Questionnaire and Clinical Dementia Rating. In addition, memory compensation (calendar) training and cognitive exercise appeared to have associations (moderate effect sizes) with better functional outcomes. Withholding SG or WE appeared to have little effect on functioning at 18 months.

Conclusions:

Overall, these results add to the growing literature that physical exercise can play a significant and lasting role in modifying outcomes in a host of medical conditions, including neurodegenerative diseases.
THE BOREL CHARACTER
Authors: Déglise Frédéric , Fasel Jean
Published: July 2021

The main purpose of this article is to define aquadraticanalogue of the Chern character, the so-called Borel character, that identifies rational higher Grothendieck-Witt groups with a sum of rational Milnor-Witt (MW)-motivic cohomologies and rational motivic cohomologies. We also discuss the notion of ternary laws due to Walter, a quadratic analogue of formal group laws, and compute what we call the additive ternary laws, associated with MW-motivic cohomology. Finally, we provide an application of the Borel character by showing that the Milnor-WittK-theory of a fieldFembeds into suitable higher Grothendieck-Witt groups ofFmodulo explicit torsion.
Examining the Vanishing Twin Hypothesis of Neural Tube Defects: Application of an Epigenetic Predictor for Monozygotic Twinning
Authors: van Dongen Jenny , Gordon Scott D. , Odintsova Veronika V. , McRae Allan F. , Robinson Wendy P. , Hall Judith G. , Boomsma Dorret I. , Martin Nicholas G.
Published: July 2021

Strong associations between neural tube defects (NTDs) and monozygotic (MZ) twinning have long been noted, and it has been suggested that NTD cases who do not present as MZ twins may be the survivors of MZ twinning events. We have recently shown that MZ twins carry a strong, distinctive DNA methylation signature and have developed an algorithm based on genomewide DNA methylation array data that distinguishes MZ twins from dizygotic twins and other relatives at well above chance level. We have applied this algorithm to published methylation data from five fetal tissues (placental chorionic villi, kidney, spinal cord, brain and muscle) collected from spina bifida cases (n = 22), anencephalic cases (n = 15) and controls (n = 19). We see no difference in signature between cases and controls, providing no support for a common etiological role of MZ twinning in NTDs. The strong associations therefore continue to await elucidation.
Atmospheric Hydrogen Peroxide (H2O2) at the Foot and Summit of Mt. Tai: Variations, Sources and Sinks, and Implications for Ozone Formation Chemistry
Authors: Ye Can , Xue Chaoyang , Zhang Chenglong , Ma Zhuobiao , Liu Pengfei , Zhang Yuanyuan , Liu Chengtang , Zhao Xiaoxi , Zhang Wenjin , He Xiaowei , Song Yifei , Liu Junfeng , Wang Weihao , Sui Benhui , Cui Ran , Yang Xue , Mei Rubo , Chen Jianmin , Mu Yujing
Published: July 2021

Hydrogen peroxide (H2O2) acts as a terminal sink for atmospheric HOx radicals (OH and HO2), playing a key role in tropospheric O3 formation. However, there are few field measurements of atmospheric H2O2 to assess its role in O3 formation, especially for the seriously polluted region of the North China Plain. In this study, H2O2 concentrations were measured at the foot of Mt. Tai from May to July 2018 and the summit of Mt. Tai from May to June 2019, with average values of 0.93 ± 1.01 and 2.05 ± 1.20 ppb, respectively. H2O2 exhibited a pronounced diurnal variation with a noon‐peak at the foot of Mt. Tai, which could be well reproduced by a gas‐phase box model with H2O2 dry deposition velocity of 3 cm s−1 included, indicating H2O2 was mainly photochemically produced. Modeling analysis showed H2O2 production at the foot was most sensitive to alkenes and aromatics, while the source and sink for H2O2 were dominated by HO2 recombination and dry deposition, respectively. Compared with the summer‐measurement in 2007, the remarkable elevation of H2O2 at the summit might be ascribed to volatile organic compounds (VOCs) increase and SO2 decline. Both H2O2‐O3 correlation and H2O2/NOz ratio suggested O3 formation at the foot of Mt. Tai was mainly VOC‐sensitive in the early morning and shifted to NOx‐sensitive thereafter. Therefore, reduction of VOCs emission especially for the reactive species of alkenes and aromatics in the morning as well as NOx emission around noontime will be effective for mitigating the serious O3 (as well as H2O2) pollution in Tai'an city.
An Improved Universal Fusion Algorithm for Constructing 3D Multiscale Porous Media
Authors: Song Shuaibing , Li Ming , Tu Qingyi , Yuan Anying , Jiao Zhenhua , Li Pan , Qian Wenxin , Liu Hewu , Xu Nan
Published: July 2021

Various types of porous media materials inherently contain pore structures of different scales, ranging from nanoscale to millimeter scale. Due to the limitations of the existing imaging technology, it is challenging and intractable for any single method to obtain and characterize the multiscale pore structure features of porous media accurately and comprehensively. To address the issue, according to the inherent logical correspondence and mutual conversion relationship between different‐scale image pixels, we propose an improved universal fusion algorithm for constructing three‐dimensional (3D) multiscale porous media. We successfully applied this algorithm to the construction of multiscale pore structure model of carbonate rock, sandstone and coal, and subsequently made quantitative extractions and characterizations of their pore structure characteristics. In addition, the finite element method (FEM) was used to calculate their absolute permeability. The results show that the improved fusion algorithm can effectively solve the problem of pore bias of the existing algorithm, which reduces the porosity of the multiscale model to a certain extent, while maintaining good pore interconnectivity. Besides, the multiscale model obtained by the improved fusion algorithm has a wider pore size distribution interval than that of the existing algorithm, and the absolute permeability of the former, computed using the FEM, is closer to the laboratory‐measured value than that of the latter.
Electron spin resonance resolves intermediate triplet states in delayed fluorescence
Authors: Drummond Bluebell H. , Aizawa Naoya , Zhang Yadong , Myers William K. , Xiong Yao , Cooper Matthew W. , Barlow Stephen , Gu Qinying , Weiss Leah R. , Gillett Alexander J. , Credgington Dan , Pu Yong-Jin , Marder Seth R. , Evans Emrys W.
Published: July 2021

Molecular organic fluorophores are currently used in organic light-emitting diodes, though non-emissive triplet excitons generated in devices incorporating conventional fluorophores limit the efficiency. This limit can be overcome in materials that have intramolecular charge-transfer excitonic states and associated small singlet-triplet energy separations; triplets can then be converted to emissive singlet excitons resulting in efficient delayed fluorescence. However, the mechanistic details of the spin interconversion have not yet been fully resolved. We report transient electron spin resonance studies that allow direct probing of the spin conversion in a series of delayed fluorescence fluorophores with varying energy gaps between local excitation and charge-transfer triplet states. The observation of distinct triplet signals, unusual in transient electron spin resonance, suggests that multiple triplet states mediate the photophysics for efficient light emission in delayed fluorescence emitters. We reveal that as the energy separation between local excitation and charge-transfer triplet states decreases, spin interconversion changes from a direct, singlet-triplet mechanism to an indirect mechanism involving intermediate states.
Sustainable production of benzene from lignin
Authors: Meng Qinglei , Yan Jiang , Wu Ruizhi , Liu Huizhen , Sun Yang , Wu NingNing , Xiang Junfeng , Zheng Lirong , Zhang Jing , Han Buxing
Published: July 2021

Benzene is a widely used commodity chemical, which is currently produced from fossil resources. Lignin, a waste from lignocellulosic biomass industry, is the most abundant renewable source of benzene ring in nature. Efficient production of benzene from lignin, which requires total transformation of Csp2-Csp3/Csp2-O into C-H bonds without side hydrogenation, is of great importance, but has not been realized. Here, we report that high-silica HY zeolite supported RuW alloy catalyst enables in situ refining of lignin, exclusively to benzene via coupling Bronsted acid catalyzed transformation of the Csp2-Csp3 bonds on the local structure of lignin molecule and RuW catalyzed hydrogenolysis of the Csp2-O bonds using the locally abstracted hydrogen from lignin molecule, affording a benzene yield of 18.8% on lignin weight basis in water system. The reaction mechanism is elucidated in detail by combination of control experiments and density functional theory calculations. The high-performance protocol can be readily scaled up to produce 8.5 g of benzene product from 50.0 g lignin without any saturation byproducts. This work opens the way to produce benzene using lignin as the feedstock efficiently.
Soft, tough, and fast polyacrylate dielectric elastomer for non-magnetic motor
Authors: Yin Li-Juan , Zhao Yu , Zhu Jing , Yang Minhao , Zhao Huichan , Pei Jia-Yao , Zhong Shao-Long , Dang Zhi-Min
Published: July 2021

Dielectric elastomer actuators (DEAs) with large electrically-actuated strain can build light-weight and flexible non-magnetic motors. However, dielectric elastomers commonly used in the field of soft actuation suffer from high stiffness, low strength, and high driving field, severely limiting the DEA’s actuating performance. Here we design a new polyacrylate dielectric elastomer with optimized crosslinking network by rationally employing the difunctional macromolecular crosslinking agent. The proposed elastomer simultaneously possesses desirable modulus (~0.073 MPa), high toughness (elongation ~2400%), low mechanical loss (tan δm = 0.21@1 Hz, 20 °C), and satisfactory dielectric properties ($${\varepsilon }_{{{{{{\rm{r}}}}}}}$$

ε

r

 = 5.75, tan δe = 0.0019 @1 kHz), and accordingly, large actuation strain (118% @ 70 MV m−1), high energy density (0.24 MJ m−3 @ 70 MV m−1), and rapid response (bandwidth above 100 Hz). Compared with VHBTM 4910, the non-magnetic motor made of our elastomer presents 15 times higher rotation speed. These findings offer a strategy to fabricate high-performance dielectric elastomers for soft actuators.
Thickness-independent scalable high-performance Li-S batteries with high areal sulfur loading via electron-enriched carbon framework
Authors: Wang Nana , Zhang Xiao , Ju Zhengyu , Yu Xingwen , Wang Yunxiao , Du Yi , Bai Zhongchao , Dou Shixue , Yu Guihua
Published: July 2021

Increasing the energy density of lithium-sulfur batteries necessitates the maximization of their areal capacity, calling for thick electrodes with high sulfur loading and content. However, traditional thick electrodes often lead to sluggish ion transfer kinetics as well as decreased electronic conductivity and mechanical stability, leading to their thickness-dependent electrochemical performance. Here, free-standing and low-tortuosity N, O co-doped wood-like carbon frameworks decorated with carbon nanotubes forest (WLC-CNTs) are synthesized and used as host for enabling scalable high-performance Li-sulfur batteries. EIS-symmetric cell examinations demonstrate that the ionic resistance and charge-transfer resistance per unit electro-active surface area of S@WLC-CNTs do not change with the variation of thickness, allowing the thickness-independent electrochemical performance of Li-S batteries. With a thickness of up to 1200 µm and sulfur loading of 52.4 mg cm−2, the electrode displays a capacity of 692 mAh g−1 after 100 cycles at 0.1 C with a low E/S ratio of 6. Moreover, the WLC-CNTs framework can also be used as a host for lithium to suppress dendrite growth. With these specific lithiophilic and sulfiphilic features, Li-S full cells were assembled and exhibited long cycling stability.
Dopamine-loaded nanoparticle systems circumvent the blood–brain barrier restoring motor function in mouse model for Parkinson’s Disease
Authors: Monge-Fuentes Victoria , Biolchi Mayer Andréia , Lima Marcos Robalinho , Geraldes Luiza Ribeiro , Zanotto Larissa Nepomuceno , Moreira Karla Graziella , Martins Olimpia Paschoal , Piva Henrique Luís , Felipe Maria Sueli Soares , Amaral Andre Correa , Bocca Anamélia Lorenzetti , Tedesco Antonio Claudio , Mortari Márcia Renata
Published: July 2021

Parkinson's disease (PD) is a progressive and chronic neurodegenerative disease of the central nervous system. Early treatment for PD is efficient; however, long-term systemic medication commonly leads to deleterious side-effects. Strategies that enable more selective drug delivery to the brain using smaller dosages, while crossing the complex brain-blood barrier (BBB), are highly desirable to ensure treatment efficacy and decrease/avoid unwanted outcomes. Our goal was to design and test the neurotherapeutic potential of a forefront nanoparticle-based technology composed of albumin/PLGA nanosystems loaded with dopamine (ALNP-DA) in 6-OHDA PD mice model. ALNP-DA effectively crossed the BBB, replenishing dopamine at the nigrostriatal pathway, resulting in significant motor symptom improvement when compared to Lesioned and L-DOPA groups. Notably, ALNP-DA (20 mg/animal dose) additionally up-regulated and restored motor coordination, balance, and sensorimotor performance to non-lesioned (Sham) animal level. Overall, ALNPs represent an innovative, non-invasive nano-therapeutical strategy for PD, considering its efficacy to circumvent the BBB and ultimately deliver the drug of interest to the brain.