bluuebunny/crossref_metadata_2025 huggingface dataset:
LINC00323 induced by hypoxia promote cartilage callus by interacting with FUS to regulate PDGFB expression
Authors: 黄 Jiang , Wang Ju yong , Sun Xiang Yao , An Shuai , Cao Guang Lei
Published: February 2024

Intermittent hypoxia has been reported to contribute beneficial effects on fracture healing depending on various factors like duration, frequency, and severity. Yet, little is known about the underlying molecular mechanism. Our previous study found that LINC00323 was up-regulated under hypoxic conditions, suggesting that it might play a final role in hypoxia-induced fracture repair. The present study is to investigate the osteogenic effect of LINC00323 in vitro and in vivo. Upregulation of LINC00323 enhanced the mineralization and activity ALP and increased the expression of osteogenic markers. Further analysis revealed that LINC00323 promoted PDGFB expression by binding FUS to regulate the growth and osteogenic differentiation of MC3T3-E1. Lentivirus mediated LINC00323 particles were injected into the fracture site of the tibia of mice, and fracture healing was evaluated by X-rays, micro-CT examination, biomechanical test and histological staining. Local injection of Lentivirus-LINC00323 increased bone mass, biomechanical strength and cartilage callus formation. These findings indicated that LINC00323 induced the differentiation of osteoblast-like cells via regulation of the expression of PDGFB, represents a theoretical basis to accelerate fracture healing.
Shuffle Attention-based CNN Network for Visual Place Recognition
Authors: YE MINYING , JIN Yongze , LIU Yu , SHANGGUAN Anqi
Published: February 2024

Robot visual place recognition is a research hotspot, and robot place recognition systems based on 3D point clouds are even more focused. In recent years, scan-context descriptor imagery has become a standard method for 3D point cloud positioning. Based on its system characteristics, we integrated it with the Shuffle Attention (SA) mechanism module to improve its system performance. And we tested it on the public database NCLT dataset (North Campus Long-Term Vision dataset), and our method has good place recognition results.
Synthesis and evaluation of chitosan/miR-125b nanoparticles for targeting Raf-1 and BMPR1b genes in MCF-7 breast cancer cells
Authors: Norouzi Raana , Abousalehi Neda , Afshar Akbar Safipour
Published: February 2024

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and play important roles in cancer development and progression. MiR-125b-5p is a miRNA that has been reported to have diverse and context-dependent effects on different cancer types and subtypes. In this study, we aimed to investigate the expression and function of miR-125b-5p in MCF-7 breast cancer cells and to explore the potential of using chitosan nanoparticles for miR-125b-5p delivery. We found that miR-125b-5p was downregulated in MCF-7 cells compared to normal mammary epithelial cells, and that its overexpression reduced the viability of MCF-7 cells by targeting Raf-1 and BMPR1b genes, which are involved in cell survival and proliferation. We also synthesized and characterized chitosan/miR-125b nanoparticles (CNPs) and evaluated their in vitro release profile and cellular uptake. We showed that CNPs enhanced the delivery and efficiency of miR-125b-5p, resulting in a more potent inhibition of Raf-1 and BMPR1b gene expression and a greater reduction of cell viability. Our results suggest that miR-125b-5p and CNPs have potential anti-tumor effects on human breast cancer cells by suppressing Raf-1 and BMPR1b gene expression. Our study provides a new insight into the role and mechanism of miR-125b-5p and its target genes in breast cancer, and demonstrates the feasibility and efficacy of using chitosan nanoparticles for miR-125b-5p delivery.
The Effects of Health Education on Acute Intermittent Porphyria Attacks : A Retrospective Cohort Study
Authors: Zhao Lanlan , Li Jie , Li Pei , Zhao Xin , Ma Ningzhen , Zhang Songyun
Published: February 2024

Background: Acute Intermittent Porphyria (AIP) is characterized by acute attacks of neurovisceral symptoms. Infection and negative emotions are factors that can trigger acute AIP attacks, thus avoiding these potential triggers can effectively reduce the risk of acute attacks. During the COVID-19 pandemic, online health education provides patients with a convenient and safe way to receive health education, thus effectively improving their quality of life（QoL）. We explored the effect of online health education on acute AIP attacks during the COVID-19 pandemic.
Methods：This study retrospectively included 47 patients with AIP who were infected with COVID-19 and completed a questionnaire from November 2022 to March 2023. These participants were divided into two groups based on whether they had received centralized health education during COVID-19. The primary outcomes were acute AIP attacks, AIP attack severity, and QoL. Secondary outcomes were negative emotions and positive coping styles.
Results: In comparison to the non-health education group, the health education group showed a significant decrease in the incidence of acute AIP attacks (P < .05), a reduction in the severity of AIP attacks (P < .05), and an improvement in QoL (P < .05). Additionally, the health education group had a significant decrease in negative emotions (P < 0.05) and a substantial increase in positive coping styles (P < 0.05).
Conclusions: Health education may enhance patients' cognition and coping skills, and reduce negative emotions, thereby reducing the occurrence and severity of acute AIP attacks, and improving the patients' QoL.
Hyper-enrichment of heavy rare earth elements in highly evolved granites through multiple hydrothermal mobilizations
Authors: Li Martin Yan Hei , Zhou Mei-Fu
Published: February 2024

Highly evolved granites can be important hosts of rare earth element (REE) resources, and more importantly, they commonly serve as the protolith for regolith-hosted REE deposits to form during weathering. Highly evolved granites in the Zudong pluton, South China, are extremely rich in the heavy (H)REE (up to 8000 ppm total HREE), and display significant REE fractionation. Moreover, the HREE enrichment is positively correlated with the degree of REE fractionation, indicating a unique process in preferentially enriching the HREE during the evolution of the granites. Multiple stages of hydrothermal re-mobilization of the REE can account for the HREE mineralization, and these are recorded in the texture and composition of the zircon. In these processes, fluctuations in the F activity of the fluid caused alternating dissolution-reprecipitation and continuous growth of the zircon. REE were repeatedly mobilized and enriched in the fluid to precipitate the major HREE mineral synchysite-(Y), and partially incorporated into the growth zone of zircon, while other elements were largely lost to the fluid during the extensive dissolution of the rock-forming minerals. LREE were also likely substantially mobilized in the late hydrothermal stage and lost through complexation with Cl, causing the significant LREE depletion and, thus REE fractionation. This process continuously enriched host granites in the HREE to a potentially economic grade, making them favorable protoliths for subsequent supergene regolith-hosted HREE deposits.
Tetrahedral aluminum in tourmaline from a spinel-pargasite-metamorphosed mafic-ultramafic rock
Authors: Vereshchagin Oleg S. , Gritsenko Yuliya D. , Vigasina Marina F. , Dedushenko Sergey K. , Gorelova Liudmila A. , Pautov Leonid A. , Agahanov Atali A. , Chernyshova Irina A. , Zolotarev Anatoly A.
Published: February 2024

Tourmaline is a widespread borosilicate mineral that is well known for its variable chemistry. Although a major amount of octahedral Al in tourmaline is commonplace, the occurrence of significant amounts of tetrahedral Al is relatively rare. This paper focuses on tourmaline from the collection of the A.E. Fersman Mineralogical Museum (Russia) originated from Italy with up to 25% of Si replaced by Al at the tetrahedral site. The tourmaline is characterized by optical and scanning electron microscopy, Raman spectroscopy, infrared spectroscopy, Mössbauer spectroscopy, energy-dispersive and wavelength-dispersive X-ray analysis, laser ablation inductively coupled plasma optical emission spectrometry and single-crystal X-ray diffraction. The studied tourmaline occurs as transparent dark blue crystals (with equant external morphology) up to 3 mm in size and forms veinlets cutting a (Mg,Al)-rich metamorphosed mafic-ultramafic rock (Mg >> Fe) composed of spinel, pargasite, clinochlore, phlogopite, and hydroxylapatite. The studied tourmaline meets the criteria defining magnesio-lucchesiite and can be compositionally formed via Tschermak-like ([6]Me2+ + [4]Si4+ ↔ [6]Al3+ + [4]Al3+, where [6]Me2+ = Mg,Fe) or plagioclase-like ([9]Ca2+ + [4]Al3+ ↔ [9]Na+ + [4]Si4+) substitutions. Zones with a relatively high Si content (Si-rich) have pronounced indications of dissolution, while silicon-depleted zones (Si-poor) overgrow Si-rich zones, eventually creating a visible replacement zone of the crystal. We suggest that Si-poor tourmaline results from the Si-rich tourmaline losing Si during a metasomatic process. The resulting empirical crystal-chemical formula for the Si-poor zone is: X(Ca0.95Na0.03☐0.02)Σ1.00Y(Mg1.08 Al0.98Fe0.502+Fe0.433+)Σ3.00Z(Al5.91Fe0.093+)Σ6.00T[(Si4.57Al1.43)Σ6.00O18] (BO3)3V(OH)3W[O0.95(OH)0.05]Σ1.00 [a = 15.9811(2), c = 7.12520(10) Å, R1 = 1.7%] and for the Si-rich zone is: X(Ca0.89Na0.11)Σ1.00Y(Mg1.55Al0.80Fe0.342+Fe0.313+)Σ3.00Z(Al5.51Mg0.44Fe0.053+)Σ6.00T[(Si5.35Al0.65)Σ6.00O18] (BO3)3V(OH)3W[O0.93(OH)0.07]Σ1.00 [a = 15.9621(3), c = 7.14110(10) Å, R1 = 1.7%]. According to pressure-temperature (P-T) calculations of mineral assemblage stability and comparable data on synthetic [4]Al-rich tourmalines, the studied tourmaline was formed at 600–750 °C and 0.10–0.20 GPa. The formation of tetrahedral Al-rich tourmalines requires several unusual factors: (1) desilication of primary rocks and (2) high temperatures and relatively low pressures.
Characterization and potential toxicity of asbestiform erionite from Gawler Downs, New Zealand
Authors: Patel Janki Prakash , Brook Martin , Kah Melanie , Hamilton Ayrton , Gamberini Maria Cristina , Zoboli Carlotta , Mugnaioli Enrico , Malferrari Daniele , Fantini Riccardo , Arletti Rossella , Gualtieri Alessandro F.
Published: February 2024

Erionite is the name for a zeolite mineral series originating from diagenesis or hydrothermal alteration of volcanic rocks. The particular erionite “species” is based on the dominant extra-framework cation, erionite-Ca, erionite-K, or erionite Na. Irrespective of the species, erionite can display a fibrous/asbestiform morphology and has been linked with cases of malignant mesothelioma, a disease typically associated with asbestos exposure. Characterization of new discoveries of erionite is therefore important to assess any potential exposure hazards. This study describes a new asbestiform erionite from vesicles within the Upper Cretaceous Mt. Somers Volcanics Group (MSVG), Canterbury, New Zealand. The erionite is within the Hinds River Dacite, the youngest unit within the MSVG at Gawler Downs, ~100 km west of Christchurch, in the foothills of the Southern Alps. A multi-analytical approach was taken to analyze the sample which included micro-Raman spectroscopy, thermogravimetric analysis, electron microscopy, electron microprobe analysis, and X-ray powder diffraction with the Rietveld method. Results confirmed the mineral as fibrous erionite-K. The chemical composition of the mineral is unique due to the presence of higher levels of Mg. While Fe was also identified, this was due to smectite flakes occurring on the surface of the erionite fibers. According to the World Health Organization (WHO) respirable mineral fiber definition, where length ≥5 μm, width ≤3 μm, and aspect ratio (L/w) ≥3:1, the Gawler Downs erionite fibers are respirable, while the fibers themselves exceed respirable thickness. In addition to morphology, a value for the potential toxicity model was computed to be 2.28 for the Gawler Downs erionite. This is similar to those of other carcinogenic erionites from Karain, Turkey (2.33), and Nevada, U.S.A. (2.28). Taken together, results indicate Gawler Downs erionite represents an environmental hazard. Nevertheless, further investigation is required to determine potential environmental exposure pathways by which erionite may become airborne and assess the actual environmental risk in the Gawler Downs area.
Real-space spectral simulation of quantum spin models: Application to generalized Kitaev models
Authors: Brito Francisco M. O. , Ferreira Aires
Published: February 2024

The proliferation of quantum fluctuations and long-range entanglement presents an outstanding challenge for the numerical simulation of interacting spin systems with exotic ground states. Here, we present a toolset of Chebyshev polynomial-based iterative methods that provides a unified framework to study the thermodynamical properties, critical behavior and dynamics of frustrated quantum spin models with controlled accuracy. Similar to previous applications of the Chebyshev spectral methods to condensed matter systems, the algorithmic complexity scales linearly with the Hilbert space dimension and the Chebyshev truncation order. Using this approach, we study two paradigmatic quantum spin models on the honeycomb lattice: the Kitaev-Heisenberg (K-H) and the Kitaev-Ising (K-I) models. We start by applying the Chebyshev toolset to compute nearest-neighbor spin correlations, specific heat and entropy of the K-H model on a 24-spin cluster. Our results are benchmarked against exact diagonalization and a popular iterative method based on thermal pure quantum states. The transitions between a variety of magnetic phases, namely ferromagnetic, Néel, zigzag and stripy antiferromagnetic and quantum spin liquid phases are obtained accurately and efficiently. We also determine the temperature dependence of the spin correlations, over more than three decades in temperature, by means of a finite temperature Chebyshev polynomial method introduced here. Finally, we report novel dynamical signatures of the quantum phase transitions in the K-I model. Our findings suggest that the efficiency, versatility and low-temperature stability of the Chebyshev framework developed here could pave the way for previously unattainable studies of quantum spin models in two dimensions.
STUDY OF RATE, CAUSE AND PATTERN OF HOSPITAL READMISSIONS IN EMERGENCY MEDICINE OF A TERTIARY CARE HOSPITAL IN NORTH INDIA
Authors: Junaid Khursheed Sahibzada , F.A Jan , Shahnawaz H. , Amin Irum
Published: February 2024

Introduction: Hospital readmission rates serve as crucial indicators of healthcare quality, with significant implications for patient outcomes and financial costs. This study aims to investigate the rates, causes, and patterns of hospital readmissions in the emergency medicine department of a tertiary care hospital in North India. Methodology: A prospective study spanning one year was conducted, involving 4116 patients admitted through emergency medicine. The study analyzed readmission rates at different intervals (7 days, 30 days, 90 days, and 1 year) and considered demographic factors, primary diagnoses, and comorbidities. Data were collected through systematic random sampling and reinforced with semi-structured interviews and administrative records. Results & Observations: The study revealed varying readmission rates across different time intervals and diagnoses. Gastrointestinal disorders and respiratory diseases consistently exhibited elevated readmission rates. Age, gender, and Charlson Comorbidity Index were identified as significant factors influencing readmission patterns. Patients aged 50-59 years and males demonstrated higher readmission rates. The severity of comorbidities, as measuredbytheCharlson Comorbidity Index, was positivelycorrelated with increased readmission rates. Discussion: The findings underscore the importance of targeted post-discharge care, disease-specific interventions, and tailored strategies for specific demographics. The study emphasizes the need for enhanced monitoring and interventions, especially in the later stages post-discharge. Patient-centric insights highlight the role of discharge readiness and patient perceptions in influencing readmission dynamics. Conclusion: This study provides comprehensive insights into the complex factors influencing hospital readmissions in the emergency medicine setting. It emphasizes the necessity for focused interventions, customized care strategies, and all-encompassing approaches to reduce readmission risks. Healthcare institutions are encouraged to prioritize transitional care, interdisciplinary collaboration, evidence-based interventions, and patient-centered care models to optimize patient outcomes and alleviate the economic burden associated with avoidable readmissions.
CONTROL OF THE EFFECTIVENESS OF MANAGEMENT OF ASSETS OF HIGHER EDUCATION INSTITUTIONS
Authors:   Head of the Financing Department, Uzbekistan., Shokhrukh Yakubov ,   Tashkent State University of Economics.
Published: February 2024

A key part of the discussion is the analysis of Tashkent State University of Economics. This case study exemplifies the impact of methodical financial results management on the universitys asset status. It illustrates that the strategic organization of financial outcomes can significantly alter the property holdings and financial standing of an institution.Furthermore, the article underscores the necessity of effective financial resource management and utilization. It posits that adept handling of these resources is instrumental in enhancing the performance of various activities within the institution. The correlation between judicious financial resource management and the overall operational success of higher education institutions is a central theme.This shift towards financial autonomy in higher education is not without its challenges. The paper explores these challenges, offering insights into how institutions can navigate this new financial landscape. It proposes that adopting innovative management strategies can lead to more efficient and effective use of financial resources, thereby improving institutional outcomes.
THE EFFECT OF CEFIXIME IN TREATING RESPIRATORY TRACT AND URINARY TRACT INFECTIONS IN CHILDREN
Authors:   Department of Paediatrics, Faculty of Medicine, Taif University, Taif, Saudi Arabia., Tamur Shadi
Published: February 2024

Third generation cephalosporins are commonly used for the treatment of diverse infections in children. Cefixime is an oral third-generation cephalosporin with a broad-spectrumantibacterial activity and a relatively long elimination half-life. It is available in oral, intravenous, and intramuscular forms. It is effective against certain bacteria, such as Streptococci, Neisseria gonorrhoeae, Moraxella catarrhalis, Haemophiles influenzae, and Gram-negative bacilli. However, it is poorly active against Staphylococcus aureus, Coagulase-negative Staphylococci, and Enterococci. Clinical trials have shown that cefixime is comparable to amoxicillin and cefaclor in treating acute otitis media in children caused by various organisms, including Streptococcus pneumoniae. It is more potent than other cephalosporins against Enterobacteriaceae but less activeagainst ciprofloxacin. The recommended dosage for children is 8 mg/kg/day orally, once daily or in two divided doses and the most prominent side effect is diarrhea, which occurs in up to16% of children. Cefixime is a safe and effective for treating upper respiratory tract infections and acute otitis media. However, there is insufficient evidence regarding its efficacy in treating sinusitis and lower respiratory tract infections in children as its antimicrobial spectrum does cover the bacteria commonly associated with these infections. Due to its partial excretion through the kidneys, cefixime is frequently used to treat urinary tract infections in children.
FACIAL EXPRESSION RECOGNITION
Authors:   UG Students, Department of Computer Science and Engineering HMR Institute of Technology and Management, Delhi, India., Mehra Shivam , Parashar Prabhat ,   UG Students, Department of Computer Science and Engineering HMR Institute of Technology and Management, Delhi, India., Aggarwal Akshay ,   UG Students, Department of Computer Science and Engineering HMR Institute of Technology and Management, Delhi, India., Rawat Deepika ,   Asst. Professor, Department of Computer Science and Engineering HMR Institute of Technology and Management, Delhi, India.
Published: February 2024

Facial Expression Recognition is a system which provides an interface for computer and human interaction. With the advancement of technology and need of the hour such systems have earned the interest of researchers in psychology, medicine, computer science and similar other fields as its applications are identified in such fields. Facial expression recognizer is an application which uses live data coming from the camera or even the existing videos to capture the expressions of the person in the video and is represented on the screen in the form of attractive emojis. Expressions form the basis of human communication and interaction. Expressions are used as a crucial tool to study the behaviour in the medicine and psychological fields to understand the state of mind of the people. The main objective to develop such a system was to be able to classify facial expressions using CNN algorithm which is responsible for the expression detection and then providing a corresponding emoticon relevant to detected facial expression as the output.
ASSESSMENT OF RADIATION RISK LEVELS ASSOCIATED WITH NATURAL (226RA, 232TH, AND 40K) AND ARTIFICIAL (137CS) RADIONUCLIDES PRESENT IN POWDERED MILK SOLD AND CONSUMED IN SENEGAL
Authors:   Institute Technologies of Nuclear Applied of Cheikh Anta Diop University of Dakar in Senegal., Dione Djicknack ,   Department of Physics of Faculty of Sciences and Technologies at Cheikh Anta Diop University of Dakar of Senegal., Macoumba Faye Papa ,   Institute Technologies of Nuclear Applied of Cheikh Anta Diop University of Dakar in Senegal.,   Department of Physics of Faculty of Sciences and Technologies at Cheikh Anta Diop University of Dakar of Senegal., Ndiaye Nogaye ,   Institute Technologies of Nuclear Applied of Cheikh Anta Diop University of Dakar in Senegal.,   Department of Physics of Faculty of Sciences and Technologies at Cheikh Anta Diop University of Dakar of Senegal., Hamady Sy Moussa ,   Institute Technologies of Nuclear Applied of Cheikh Anta Diop University of Dakar in Senegal.,   Department of Physics of Faculty of Sciences and Technologies at Cheikh Anta Diop University of Dakar of Senegal., Ndiaye Oumar ,   Institute Technologies of Nuclear Applied of Cheikh Anta Diop University of Dakar in Senegal.,   Department of Physics of Faculty of Sciences and Technologies at Cheikh Anta Diop University of Dakar of Senegal., Traore Alassane ,   Institute Technologies of Nuclear Applied of Cheikh Anta Diop University of Dakar in Senegal.,   Department of Physics of Faculty of Sciences and Technologies at Cheikh Anta Diop University of Dakar of Senegal., Sadikhe Ndao Ababacar ,   Institute Technologies of Nuclear Applied of Cheikh Anta Diop University of Dakar in Senegal.,   Department of Physics of Faculty of Sciences and Technologies at Cheikh Anta Diop University of Dakar of Senegal.
Published: February 2024

The study conducted in Senegal sought to address the dearth of data on radionuclide concentrations in milk, particularly considering the upward trajectory of domestic consumption. Employing gamma-spectrometry, researchers investigated five milk brands, calculating the resulting ingestion dose. The concentrations of 232Th, 226Ra, 137Cs, and 40K exhibited variability across brands, ranging from 0.40 Â± 0.30 for G1 to 7.58 Â± 0.37 for V1, 0.50 Â± 0.17 for V1 to 1.15 Â± 0.11 for D1, 0.06 Â± 0.05 for V1 to 0.43 Â± 0.06 for D1, L1, G1, and H1, and 16.31 Â± 4.02 for L1 to 369.26 Â± 15.84 Bq/kg for G1. Notably, the total average Annual Effective Dose for all age groups remained consistent across all brands. Importantly, the concentrations observed were found to be significantly below the guidance level recommended by the World Health Organization (WHO). As a result, the study concludes that all five milk brands investigated are considered safe for consumption, providing reassurance to the public regarding the radionuclide content in the milk supply chain in Senegal.
Staphylococcus spp. and mecA gene in pregnant women: a neglected health risk to mother and child
Authors: Mota Edinalva Almeida , Caetano Isabel Cristina da Silva , Dos Santos Isabela  Carvalho , Kassem Adma Soraia Serea , Carraro Franciele Mota , Otutumi Luciana Kazue , De Oliveira Leila Alves , Rubio Kariny Aparecida Jardim , Barbosa Lidiane Nunes , Martins Lisiane de Almeida , Gonçalves Daniela Dib
Published: February 2024

This study aimed to determine the phenotypic, molecular and epidemiological profile of methicillin resistant Staphylococcus spp. in pregnant women. Were included 100 asymptomatic pregnant women between 16 and 38 years old, who underwent microbiological examination by collecting a vaginal swab at the first trimester of pregnancy. The isolates were subjected to isolation, characterization, phenotypic and molecular tests were performed. Among the samples analyzed, were detected coagulase-negative Staphylococcus in 83%, coagulase-positive Staphylococcus, 6% and Streptococcus spp. in 5%, and there was no bacterial growth in 6%. The antibiotics that showed the highest resistance were amoxicillin + clavulanic acid and sulfamethoxazole + trimethoprim (92.77%) in coagulase-negative Staphylococcus and penicillin and sulfamethoxazole + trimethoprim in coagulase-positive Staphylococcus (100%), where in the latter S. aureus was the species identified in 66.67% of the samples. As for the identification of the mecA gene in Staphylococcus spp. samples, this gene was detected in 40.5% of the samples of coagulase-negative Staphylococcus, and it was not detected in the samples of coagulase-positive Staphylococcus. The epidemiological study showed that prior treatment with antibiotics was significantly (p≤0.016) associated with oxacillin resistance in vaginal swab samples. The presence of the mecA gene in coagulase-negative Staphylococcus isolates demonstrated a bacterial profile in this type of biological sample, different from what is already presented in the scientific literature. New studies are warranted to understand the epidemiology of the bacterial species involved and later to implement health education actions both in the target population and in health care professionals.
Neuroclusal rehabilitation with planas direct tracks in the treatment of anterior crossbite – literature review
Authors: Almeida-Junior Luciano Aparecido de , Polimeno Marcelo Muscas , Tortelli Ana Paula , Medau Valéria
Published: February 2024

Planas direct tracks (PDTs) are an alternative treatment based on neuro occlusal rehabilitation (NOR) of various occlusal changes in the primary dentition and in the beginning of mixed dentition. Anterior crossbite is a very common malocclusion during this period. The aim of the present work was to report on Planas direct tracks through a literature review based on neuro-occlusal rehabilitation as a therapy for anterior crossbite (ACB). The search for articles was performed in the databases SciELO (Scientific Electronic Library Online), MEDLINE (National Library of Medicine-USA) and Google Scholar. After searching for articles, 12 studies were listed, however, after evaluating the inclusion and exclusion criteria, only 5 articles remained. The articles found proved to be effective in resolving cases with PDTs based on NOR. PDTs were more suitable for the treatment of anterior crossbite in the primary dentition. The inclination of the tracks was variable, both in the anterior and posterior regions, between 20° and 45° degrees. Three case reports in primary dentition observed ACB correction after 30 days with PDT. As a result, two case reports reported that the treatment of ACB was resolved after 45 days with the effects of clockwise rotation of the mandible and its retropositioning. Another effect observed was the uncrossing of the anterior teeth, presenting an uncrossing of the bite and improvements in facial and postural symmetry. The NOR-based PDT for the case reports presented promoted the resolution of ACB malocclusion, promoting the correction of jaw posture, and in turn, improving the facial and postural symmetry of the mandible.
Multi-factor coupled thermal simulation of flat-panel digital PCR structure
Authors: Li Qixuan , Qin Xulei , Wang Haoyu
Published: February 2024

To achieve uniform reaction temperature in flat-plate digital polymerase chain reaction (dPCR), we propose a multi-factor coupled thermal simulation method for the structure of flat-plate digital PCR using finite element analysis. This will help us obtain the optimal method for the structure of flat-plate dPCR. Thermal simulations were conducted to analyze the effects of forced air cooling, thermoelectric cooler (TEC) arrangement spacing, and heat-conducting plate thickness on the temperature uniformity of the flat-plate dPCR. The resulting isothermal surfaces and velocity magnitude vectors were used to summarize the impact of each factor. The study found that maintaining a mechanical fan speed of 3000 revolutions per minute (RPM) ±10 % during the heating period resulted in a 29.3 % reduction in the standard deviation of the temperature on the surface of the heat-conducting plate. Additionally, when the TEC spacing was between 2 mm and 3.5 mm, the standard deviation of the temperature on the plate's surface decreased by 87.1 % to 93.4 %. When the thickness of the thermal plate ranges from 3.5 mm to 4.5 mm, the standard deviation of the temperature on the surface of the thermal plate varies by approximately 0.006. The experimental results, obtained by sampling and analyzing the temperature on the surface of the thermal plate, are consistent with the simulation results. This proves that the method is informative in determining the structural parameters of the dPCR to enhance temperature uniformity.
Research on automatic detection of gradual fault of high voltage electric energy metering transformer based on fuzzy rough set and whale optimization algorithm
Authors: Wang Chunguang , Wu Zhiwu , Huang Tianfu , Wu Xiang , Huang Hanbin
Published: February 2024

Based on fuzzy rough set and whale optimization algorithm, the automatic fault detection method of high-voltage electric energy metering transformer is studied to improve the fault diagnosis effect and efficiency. On the basis of constructing the mathematical model of gradual fault of high-voltage electric energy metering transformer, the fuzzy rough set theory is used to reduce the data attributes of fault samples, eliminate similar attributes, determine the minimum fault feature set, and complete the fault feature selection, which is used as the input of the fault detection model based on Whale Optimization Algorithm-based Support Vector Machine (WOA-SVM). After the kernel parameters and penalty factors of SVM are optimized by whale optimization algorithm, the type of gradual fault of high-voltage electric energy metering transformer is identified. The experimental results show that the reduced fault attributes are distributed differently in the sample data, and the fault detection accuracy can be improved by 9.5 % through fault feature selection. The fault diagnosis model with Gaussian radial basis function, kernel parameter of 0.05 and penalty factor of 10 has the best performance. This method can identify the gradual fault types of high-voltage electric energy metering transformers, and the fault diagnosis effect is outstanding.
Tau-fluvalinat İçerikli Bir İnsektisitin Sitotoksik ve Genotoksik Etkilerinin Allium Testi Kullanılarak İncelenmesi
Authors: İLİ Pınar
Published: February 2024

Günümüzde pestisitler tarımsal faaliyetlerde oldukça yaygın olarak kullanılmakta ve yoğun ve gelişigüzel kullanılmaları, pestisitlerin halk sağlığını ve ekosistemi tehdit etmesine neden olmaktadır. Birçok çevresel kirleticide olduğu gibi pestisitlerin de sitotoksik ve genotoksik etkileri yıllardır bir endişe kaynağıdır. Bu çalışmada sentetik bir piretroid olan tau-fluvalinat içerikli bir insektisitin (Mavrik® 2F) Allium cepa kök ucu meristemleri üzerindeki sitotoksik ve genotoksik etkileri incelenmiştir. Kök büyüme inhibisyon testi sonucunda tau-fluvalinat için etkili konsantrasyon (EC50) 330 mg/L olarak bulunmuştur. Sonrasında soğan kökleri 24 saat boyunca 3 farklı tau-fluvalinat konsantrasyonuna (165, 330 ve 660 mg/L) maruz bırakılmış ve yapılan mikroskobik incelemeler ile mitotik indeks (Mİ), faz indeksi (Fİ) değerleri ve kromozom aberasyon (KA) sıklıkları hesaplanmıştır. Yapılan istatistiksel analizler neticesinde, tau-fluvalinat içerikli model insektisitin A. cepa’da kök uzamasını inhibe edici etki gösterdiği sonucunun yanı sıra, Mİ değerini azalttığı ve Fİ değerlerini değiştirdiği için sitotoksisiteye ve KA oluşumunu artırdığı için genotoksisiteye sahip olduğu sonucuna varılmıştır. Ayrıca model insektisitin kullanılması durumunda, A. cepa üzerinde 330 mg/L tau-fluvalinat konsantrasyonunun subletal etkilere, 660 mg/L tau-fluvalinat konsantrasyonunun ise letal etkilere neden olabileceği değerlendirilmiştir. Bu çalışmanın sonuçları ışığında tau-fluvalinat içeren pestisitlerin tarımsal faaliyetlerde kullanımı esnasında çok dikkatli olunması ve toksik etkilerinin azaltılması için 165 mg/L’nin çok daha altında konsantrasyonlarının uygulanması önerilmektedir.
Optimization of gluten- free semolina dessert (revani) formulation ıncluding different flours: response surface methodology
Authors: KAVRUT Enes , YURT Bayram
Published: February 2024

Celiac syndrome occurs as a result of the deterioration of the natural structure of the intestine due to the consumption of foods containing gluten. Since semolina dessert contains gluten protein, it cannot be consumed by celiac patients. The production of alternative gluten-free products shows that these products are of great importance for this patient group. In this study, gluten-free semolina dessert formulations using rice flour (RF) and buckwheat flour (BWF) and chestnut flour (CF) were optimized using Response Surface Methodology (RSM). Potato Starch (PS) was added to the samples containing BWF and CF. It was determined that the addition of PS increased the processibility of the flour of the semolina dessert prepared with chestnut flour and the consumability of the semolina dessert prepared with buckwheat flour. It was determined that the use of different grades of flour, potato starch/corn semolina mixture, egg white and yolk powder and drinking water increased the volume, symmetry index, chewiness and texture values of the sample (p<0.05). When all components are taken into account, in BWF formulation (62.5/37.5) % flour/corn semolina mixture, 75.85% drinking water 14.73 egg white and yolk powder (same amount) and (50/50) flour/corn semolina mixture in RF formulation, % 81.46, drinking water 14.91% yolk and egg white powder (same amount), in CF formulation (50/50) flour/corn semolina mixture, 60.30% water when drinking, 14.95% egg white and yolk It was possible to produce gluten-free semolina, which is the closest dessert to the control sample semolina dessert by using powdered semolina. As a result of the sensory scores of the prepared revanis (with different formulations), the control sample, rice, chestnut and buckwheat semolina dessert got the highest score, respectively.
Anticancer Activities of Zinc Oxide Nanoparticles (ZnONPs) Synthesized from Mentha longifolia L. Leaf Extract
Authors: İPEK Polat , BARAN Mehmet Fırat , HATİPOĞLU Abdulkerim , BARAN Ayşe
Published: February 2024

Recently, there has been a remarkable increase in cancer and cancer-related deaths. In this study, the impacts of zinc oxide nanoparticles (ZnONPs) produced from the aqueous leaf extract of Mentha longifolia L. (ML) on ovary adenocarcinoma (OVCAR-3), colorectal carcinoma (HCT-116), and healthy retinal pigment epithelial cell (RPE-1) lines were investigated. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) test was performed to discover its antiproliferative properties. As a result of the application of ML-ZnONPs on RPE-1, OVCAR-3, and HCT-116 cell lines at doses (µg/mL) of 250, 500, and 1000 for 24 hours, the viability rates (%) in the cell lines were 18.73-30.56, 21.98-28.76, and 27.27-40.93, respectively. In the 48-hour application, the viability rates (%) of the same cells were between 29.51-46.83, 32.49-40.81, and 46.82-44.37, respectively. The MTT test revealed that ML-ZnONPs strongly suppressed the growth of RPE-1, OVCAR-3, and HCT-116 cell lines. The test showed that the effect of dose increase and time on the viability of both cancer cell lines was negative.
Seasonal quality and statistical assessment of physicochemical properties and base saturation of Hadejia-Nguru wetland soils, Northwest/Eastern Nigeria
Authors: Mohammed Sa'adatu Eri , Aderibigbe Deborah Olubunmi , Saeed Muhammad Dayyab , Nelana Simphiwe Maurice , Musa Ahmadu , Sunday Ayanda Olushola
Published: February 2024

The evaluation of Hadejia-Nguru wetland soils was carried out for two consecutive dry seasons. Standard analytical techniques were adopted to analyze the samples and statistical models were used to assess the spatial and temporal distribution of the parameters selected. The average pH values of the soil samples were mostly alkaline, and all the measured values were also within the approved standards. Experimental results revealed a significantly positive correlation between Ca and Mg for both seasons as indicated by the p-values and a high coefficient of determination (R2) for both metals with cation exchange capacity (CEC) values as the predictors. The regression analysis showed that the changes in CEC and pH levels in the soil were dependent on changes in Ca and Mg content of the soil. The data obtained showed that the increase in pH is directly proportional to the CEC and base saturation of the soils. A higher percentage of Ca than other cations (Mg, K and Na) was observed from the base saturation of the soils. The pH, base saturation, and CEC levels in the soils are suitable for most crops grown in the area, which has the potential to support a wide range of crops with further exploration.
A compreensão do discurso e as mídias
Authors: De Lima Pacheco Márcio
Published: February 2024

Na oportunidade de se fazer crível e útil à compreensão do fenômeno da política e do discurso, a Revista Saridh (Linguagem e Discurso) apresenta, nesta edição (volume 4, número 2 - 2022), uma entrevista com o pesquisador e professor Dr. Marcio de Lima Pacheco, da Universidade Federal de Rondônia. Trata-se de um celebrado momento de fala sobre a compreensão dos discursos e dos motivos destes nas mídias. Com a maestria e a propriedade que lhes são naturais, o professor Pacheco mobiliza em suas respostas a profundidade e delicadeza intelectual que acena, portanto, para o que constitui as amarras e as movências do sujeito no espaço intervalar das práticas políticas do presente.
Performances Poéticas | Poéticas Performativas
Authors: Ministro Bruno , Cardoso Inês , Evangelista Lúcia
Published: February 2024

Como (se) vive a poesia? Como reverbera, como se dissipa, como ressoa? Trata-se de um ato linguístico ou é algo que suplanta a língua? Como pode a poesia atuar enquanto voz e corpo, enquanto som pendurado no tempo e desenho que ocupa o espaço? Todo o poema carrega em si um fulcro performativo? Podemos vislumbrar perguntas como estas nos entrecruzamentos entre poesia e performance ao longo das décadas, seja nas práticas dos artistas ou nos estudos que sobre eles se debruçam. O livro Performances Poéticas | Poéticas Performativas surge do interesse comum de vários membros do Grupo Intermedialidades do Instituto de Literatura Comparada Margarida Losa em fazer reverberar tais questões, em responder-lhes ou lançar novas perguntas a partir delas.
Investigating Concept Mastery of Physics Students During Online Lectures Through Rasch Models on Force and Motion Materials
Authors: Sulman Fauzan , Yuliati Lia , Kusairi Sentot , Hidayat Arif , Pentang Jupeth Toriano , Mensah Bismark
Published: February 2024

Conceptual understanding and problem solving is the most crucial part of Physics Lectures. In lectures, mastery of the concept is the primary goal. This research aims to analyze students' mastery of physics concepts in the material of Force and Motion while lectures are conducted online. This study uses a mixed-method approach to explain students' answers that still need clarification. Data analysis was carried out using the Rasch model, and a questionnaire was developed based on the possibility of students' responses to the concepts of force and motion. The results of this study indicate that students' understanding of the concept of force and motion material still needs to improve, namely 64.062%, around 94% of glasses tadris students think that the force and motion material given by lecturers during exams is challenging. More than 60.94% of students believe this is because the ability of the force and motion material they have still needs to improve. These results are interpreted based on analysis through the winstep application Version 3.65.0. and for qualitative data obtained from interviews. It takes a learning model that is appropriate for use in online and offline learning.
Scientific literacy on the topic of light and optical instruments in the innovation of science teaching materials
Authors: Fahmi Fahmi , Chalisah Nur , Istyadji Maya , Irhasyuarna Yudha , Kusasi Muhammad
Published: February 2024

This study aims to innovate science teaching materials based on scientific literacy on light and optical instruments. The study used the research and development (RD) method with the four-D (4D) model. The subjects in the study included three experts and 60 class VIII students with an age range of 13-15 years at the same level. This study collected quantitative data from product validation, questionnaire, and scientific literacy test. The questionnaire and test instrument have been proven valid and reliable based on expert judgment and empirical tests. The data were analyzed using descriptive and empirical statistic tests. The expert judgment proves that science teaching materials score 3.79 of 4 and scientific literacy aspects 3.71 of 4, which is valid. In addition, the teaching materials were also categorized as effective with an overall score (z = -4.731 and p-value = 0.000 0.05). In detail, the learning process increases student scientific literacy (p-value = 0.0000.05). Furthermore, science teaching materials based on scientific literacy could be optimized to improve students' scientific literacy skills sustainably.
Scaffolding in guided inquiry learning with google classroom: Effect on physics conceptual understanding
Authors: Rahayu Murih , Asyhari Ardian , Anjani Adis Veliana
Published: February 2024

The purpose of this study is to examine the impact of student's conceptual understanding on the topic of elasticity and Hooke's Law utilizing a scaffolding-based technique guided inquiry facilitated by Google Classroom. The quasi-experimental design method is used in this investigation. This study's design includes all class XI students from one of Bandar Lampung's schools for the 2018/2019 academic year. This study employed systematic random sampling to obtain 30 students in each of the experimental and control groups. The research instrument employed was a concept understanding exam consisting of 20 two-tier diagnostic questions with a reliability level of 0.84 in the high category and suitability. The results of this study show an average value of 58.6 in the control group and 73 in the experimental group. The hypothesis results reveal that the significant value of the t-count t-table with the choice H0 is rejected, and the effect size test results suggest that d = 1.08 where d 0.8. These findings imply that the experimental class outperforms the control class. As a result, the scaffolding-based guided inquiry technique supported by Google Classroom has the potential to alter students' physics conceptual understanding.
Learning instructional using webbed models based on local potential "Pulau Kembang" to enhance ecological literacy skill
Authors: Purwasih Desy , Wilujeng Insih , Membalik Vietgar , Hasan Suhandi
Published: February 2024

The research is developing a webbed integrated science learning model based on the local potential "Pulau Kembang" discovery learning (DL) model to improve ecological literacy skills. The purpose of this research is to produce a product that is feasible, practical, and effective for use in learning. The type of research is educational research design by adapting the Borg Gall development model, consisting of ten stages. Media experts, material experts, and practitioners conducted the feasibility assessment, totaling five people. The effectiveness was obtained from a limited trial with a pretest experimental design and a posttest control group design. There is one control class and one practical class with 49 students. The effectiveness analysis used the Analysis of Variance (ANOVA). The product practicality test provides a response questionnaire with a 4-Likert scale, totaling 27 statements. The results show that the average lesson plan is 1.00 in the excellent category, the student worksheets are on average 3.56 in the excellent category, the handout is on average 3.44 in the excellent category, and the assessment instrument with a V-Aiken value of 1.00 is in an excellent category. The results of the ANOVA test get a p-value 0.005 and an effect size of 0.171 in the large category. Practicality test with an average of 3.08 suitable type. Overall, it shows that the webbed integrated model of science learning instructional based on local potential "Pulau Kembang" is feasible and practical to use in learning.
Develeopment e-modules based android in Newton’s law topic for senior high school
Authors: Eriyanti Ira Lelita , Jumadi Jumadi , Yanarti Yanarti , Rosiningtias Wiwin
Published: February 2024

Developing android-based teaching materials is an initial step to follow the presence of the society 5.0 era in the learning system. This study aimed to know the feasibility and practicality of an Android-based e-module developed on Newton's law material. This study is research and development using the 4D model from Thiagarajan with four stages of development: define, design, develop, and dissemination. The research instrument used is an expert validation sheet, students' reliability questionnaire, interview guide sheet, and e-module prototype with research subjects consisting of 50 students. The research instruments used are expert validation sheets, student reliability questionnaires, interview guide sheets, and e-module prototypes. The research subjects are 10th-grade students. The data analysis technique is quantitative descriptive. Based on expert validation, the feasibility analysis results show 94.86% and 90.8%. Results of the practicality analysis show a percentage of 100% based on the test results, which means that the android-based e-module developed meets the feasibility and practical aspects of teaching materials on Newton's law. The effective analysis results on the effective use of e-modules show N-gain 1,877 in the high category, which means that e-module developed is effective use as learning media in Newton's law material.