bluuebunny/crossref_metadata_2025 huggingface dataset:
A HOSPITAL BASED PROSPECTIVE STUDY OF PREVALENCE OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN DERMATOLOGY INDOOR PATIENTS BY PHENOTYPIC METHOD
Authors: Kumari Saroj , Kala Dogra Naina , Jandial Sunakshi , Gupta Suharshi , Sudan Sharma Shashi
Published: April 2023

Introduction: Methicillin-Resitant Staphylococcus aureus is a cause of increased morbidity and mortality in debilitated and immunocompromised indoor patients. Aim: The aim of our study was to see the prevalence of Methicillin -Resistant Staphylococcus aureus infection in dermatology indoor patients by phenotypic method and elucidate its predisposing factors and antibiotic sensitivity pattern. Methods: This was a hospital based prospective study which included all dermatology indoor patients with primary and secondary bacterial infection. Results: The study enrolled 110 indoor patients with 57 males and 53 females. The mean age of the study was 39.23 years ranging between 2-90 years. Vesicobullous disorders were the commonest dermatoses with secondary infection. Diabetes mellitus was the most common comorbidity being present in 18 patients. S. aureus was the commonest bacterial isolate grown in culture in 66 patients, accounting for 60% of the total isolate. MRSA isolates accounted for 24.55% (27) of the total isolates. Majority of the MRSA patients (n=23, 85.19%) were having HAMRSA, while only 4 MRSA patients (n=4, 14.81%) were having CAMRSA. All MRSA isolates were sensitive to vancomycin and linezolid, while all the MRSA isolates were resistant to cefoxitin, oxacillin, cloxacillin, ampicillin and ciprofloxacillin. Conclusion: The prevalence of MRSA in our study was high. A high percentage of both MSSA and MRSA isolates were sensitive to gentamicin, which is a cheaper, effective and widely available antibiotic.
THE ROLE OF SERUM ESTROGEN AND NITRIC OXIDE (NO) IN POST-MENOPAUSAL KNEE OSTEOARTHRITIC FEMALE PATIENTS
Authors: Kr. Singh Jitendra , Sharma Pradeep , Kumar Sunil , Kumar Ajai , Jawad Kalbe , Chauhan Barkha
Published: April 2023

As we are all aware the hormone estrogen is the most essential sex hormone of the female. It plays significant roles in all phases of the life of females. Osteoarthritis is the most debilitating bone disorder commonly seen in females more than males. Out of all the joints knee joint is most commonly affected as it is the weight-bearing joint. So here in this study, the main objective is to know the role of serum estrogen and Nitric oxide levels in post-menopausal knee osteoarthritic female patients. The samples were collected and the chemiluminescence and ELISA method performed the tests. Consequently, results showed decreased levels of serum Estrogen in the study group than in the control group and levels of serum nitric oxide was increased as it confirmed the inflammatory marker at the site of infection. This whole suggests that deficiency estrogen and raised nitric oxide are helpful in the diagnosis and treatment modalities of knee osteoarthritis in postmenopausal females.
CLINICAL PROFILE OF PATIENTS OF EPISCLERITIS - A HOSPITAL BASED STUDY, JHANSI
Authors:   M.S. OPHTHALMOLOGY, Professor and Head of the Department, Department of Ophthalmology, M.L.B. Medical College, Jhansi (U.P.)., Kumar Jitendra , Singh Karishma ,   Junior Resident,Department of Ophthalmology, M.L.B. Medical College, Jhansi (U.P.).
Published: April 2023

Purpose: To determine the clinical profile of patients of Episcleritis presenting to our tertiary care hospital. Methods: This was a hospital based observational study that included 100 participantspresented at the Outpatient Department of ophthalmology in our hospital with various complaints and who werediagnosed as having episcleritis. After taking written consent from the patients, all the relevant information of the cases and detailed clinical history was taken. All the standard ocular and systemic examination was performed for every patient. The diagnosis of episcleritis was made based on the slit lamp examination findings. Frequency and proportions were used in the descriptive analysis for categorical variables. The data was processed, the coding and calculation was done using MS Excel office version 2021. Results: Age of patients in our study ranged from 18 to 60 years. Maximum cases (42%) of episcleritis were in the age group of 41 to 50 years.There was male predominance (52%) in our study with majority of cases being males. Most common presenting symptom seen was redness in 89% patients, followed by ocular pain in 64%, followed by watering in 56%, discomfort in the eyes in 48 % patients and other symptomsseen were burning sensation in the eyes, foreign body sensation and photophobia in 37%, 28%, and 12 % cases respectively. Conclusion: We can infer from our study that Episcleritisis a common, acute and self- limiting disease. Cases of Episcleritis were found more commonly in the age group between 41 to 50years and in males in our study. Careful examination of the eye with slit lamp along with history taking in detail is helpful in diagnosing the cases of episcleritis.
DIGITAL HEALTH: THE FUTURE OF HEALTHCARE
Authors: Tilekar Gulab
Published: April 2023

The field of digital health is expanding quickly and uses digital technologies to improve patient outcomes and healthcare delivery. In this study, we look at the state of digital health now and consider how it can change the way that healthcare is provided in the future. Our discussion of digital therapeutics, wearables, telehealth, and mobile health covers the major subfields of digital health. We also look at the advantages and drawbacks of digital health, including data security, privacy, and moral issues. Finally, we talk about the opportunities that digital health will provide to patients, governments, and healthcare professionals.
COMMUNITY SUSTAINED MULTIDISCIPLINARY APPROACH IN COVID PANDEMIC MANAGEMENT - A FIELD EXPERIENCE FROM INDIA- A CASE REPORT
Authors:   Assistant Professor, Tirunelveli Nedical College, Tirunelveli., Mohamed Aazmi , Venugopalan Vishnu ,   District Collector, Tirunelveli., Subbiah Padmavathi ,   Scientist C, MRHRU, Kallur., Daya Appadurai Praveena ,   Assistant Professor, Tirunelveli Nedical College, Tirunelveli., Pon Ruban Charles ,   Assistant Professor, Tirunelveli Nedical College, Tirunelveli., K. Shantaraman ,   Additional DME, Directorate of Medical Education.
Published: April 2023

COVID pandemic with repeated outbreaks is associated with newer genomic variants and bound to create professional fatigue, which needs a community-based strategy to control the disease. During March 2021, the Tirunelveli district health authority adopted a Community Sustained Multidisciplinary Approach (CSMA) and was hypothesised to be more productive in managing the 2nd wave. It was a community-centric approach with primary prevention, early diagnosis & referral, early treatment and reduction of morbidity and mortality. The strategy included community-friendly lock-down with social security, community sustained micro-containment, women self-help group sustained hamlet level screening and a time-sensitive patient referral with monitoring of oxygen requirement. This study concludes that resource-constrained public health systems need to adopt a community-based approach to contain the pandemic efficiently, as demonstrated in Tirunelveli district through a Community Sustained Multidisciplinary Approach. This unique public health approach had a vital role in the efficient containment of the pandemic.
COMPARISON BETWEEN VARIOUS METHODS OF MANAGEMENT OF UTERINE POLYP AND TO FIND OUT THE MOST EFFECTIVE AND SAFE METHOD
Authors:   Junior Resident, Department of Obstetrics &Gynecology., Patil Poorva , Darawade Sameer ,   Professor, Department of Obstetrics &Gynecology., Kanhe Sanika ,   Junior Resident, Department of Obstetrics &Gynecology.
Published: April 2023

Endometrial polyp are soft, fleshy intrauterine growths are composed of endometrial glands, fibrous stroma, and surface epithelium. Prevalence inthe general population approximates 9 percent. Various modalities are available for the management of endometrial polyp. We conducted this study to compare between D & C,Hysteroscopic scissors and forceps, Monopolar Cautery with Glycine, Bipolar Cautery with normal saline as methods for polypectomy.
MANAGEMENT OF ANTERIOR CROSSBITE USING CATLANS APPLIANCE IN THE EARLY MIXED DENTITION PERIOD - A CASE REPORT
Authors: Koundal Lisma , Priyanka Kumari
Published: April 2023

In the early mixed dentition period, single tooth anterior crossbite is the commonly encountered problem. Once identified, the treatment modality should be simple, non invasive, involves little chair side time, requires minimal patient cooperation, and gives rapid correction of the crossbite without affecting the surrounding structures. Different treatment options such as removable and fixed appliances have been suggested by various authors in the past literature such as tongue blade therapy, Catlans appliance (lower inclined bite plane), crowns (either stainless steel or composite build-up), Hawleys retainer with double cantilever springs, labial and lingual arch wires. Patient compliance with a removable appliance can often be an issue in young children. This paper presents a case of anterior crossbite corrected using the Catlans appliance within a short period of three weeks without any damage to the tooth or the periodontium. This fixed appliance is a simple and economical method which does not depend on patient cooperation to reverse the bite.
MODELING AND NON-LINEAR MECHANISMS IN HETEROGENEOUS KINETICS OF THE NON-ISOTHERMAL PYROLYSIS OR HYDROPYROLYSIS FOR TARFAYA OIL SHALE (MOROCCO)
Authors:   Department of Chemistry, Faculty of Sciences Ben msik Casablanca, University Hassan II Morocco., Attaoui Abdeljabbar
Published: April 2023

The method of analysis to reach the kinetic parameters of pyrolysis or hydropyrolysis in non-isothermal (dynamic regime) has been often discussed to try to approach the reaction mechanisms. Indeed by modifying the method one makes these kinetic parameters vary considerably. Two mechanisms have been presented to discuss these non-isothermal kinetics for pyrolysis under nitrogen and hydropyrolysis under hydrogen, we have the linear mechanism and the non-linear mechanism.The method that was adopted for this work is the Coast-Redfern approximation (A.W.Coast and D.P.Redfern: 1964). We were able to achieve these kinetic parameters and design the appropriate mechanisms for the dynamic pyrolysis and hydropyrolysis of the Tarfaya oil shale (Morocco) for the Z4 layer. It turned out after discussion that it is the non-linear mechanism that fits best with pyrolysis as well as hydropyrolysis in non-isothermal mode. These two reactions are carried out by several simultaneous reactions with a fractional order for the first and an order equal to unity for the latter.
COMPLIANCE TO IRON SUPPLEMENTATION AMONG PREGNANT WOMEN WITH IRON DEFICIENCY ANEMIA IN RIYADH, SAUDI ARABIA: DETERMINANTS AND BARRIERS
Authors:   Family Medicine Resident at King Saud Medical City, Riyadh., A. Alshumaysi Almaha , S. Alshehry Bandar ,   Family Medicine Consultant at King Saud Medical City, Riyadh., M. Alghamdi Amal ,   Family Medicine Resident at King Saud Medical City, Riyadh., A. Alwalan Lama ,   Family Medicine Resident at King Saud Medical City, Riyadh., A. Alfayi Banan ,   Family Medicine Resident at King Saud Medical City, Riyadh.
Published: April 2023

Background: iron deficiency anemia among mothers is a serious public health issue.Studies found a link between adverse events and iron supplementation compliance during pregnancy. Objectives: to assess the compliance to iron supplementation among pregnant women with iron deficiency anemia in Riyadh, Saudi Arabia, and its determinants and barriers. Methods: a cross-sectional study was done in Riyadh, Saudi Arabia on pregnant women with iron deficiency anemia who attended primary health care centers (PHCCs) in Riyadh, Saudi Arabia. An online questionnaire wasused to collect data about womens demographics, obstetric and gynecological history, prescribed iron supplements, womens awareness regarding iron deficiency anemia, compliance with iron/folate supplementation, and reasons for non-compliance. Results: 74.8% of females sometimes forget to take iron supplements, 54.1% reduced or stopped taking iron supplements without telling their doctor because they felt worse when taking them, and 63.5% sometimes forget to bring or take iron supplements when they leave home. The prevalence of low, medium and high compliance with iron supplement intake was 74.2%, 15.1%, and 10.7%, respectively, among the participants.Side effects (43.4%) and forgetting (32.1%) were the most common reasons for noncompliance. High compliance was significantly higher among participants over the age of 30, with a university education or higher, in the trimester, who had â‰¥ 5 antenatal visits, and who preferred iron supplements in tablet form. Conclusion: The low observed compliance among studied females emphasizes the importance of increasing communication for behavior change and counseling before or during antenatal care to improve adherence.
NLR AND PLR WITH PHOTOTHERAPY IN NEONATAL HYPERBILIRUBINEMIA- MAKING WAY FOR NEW DIAGNOSTIC MARKERS
Authors:   School of Medical Sciences and Research Hospital, Sharda Hospital., Siddharth Reddy P.G Mothe , Pundhir S.R Sidhant ,   School of Medical Sciences and Research Hospital, Sharda Hospital.
Published: April 2023

Objective: The purpose of this study was to investigate the clinical significance of the platelet tolymphocyte ratio (PLR) and the neutrophil to lymphocyte ratio (NLR) in term neonates and its impact onmanagement of neonatal hyperbilirubinemia on phototherapy Materials and Methods: This observational study was conducted with 20term neonates diagnosed with neonatal hyperbilirubinemia, and recieved phototherapy. Exclusion criteria wereprematurity, post- maturity, small or large for gestational age according to week of pregnancy,babies born to mothers with GDM or pre-eclampsia and congenital defects. Results: NLR and PLR as predictors of effect of phototherapy, the sensitivity of NLR was 94.44 % while specificity was 86.36%. We noted that the sensitivity of PLR was 84.21%, while specificity of PLR was 80.95%. There was a positive correlation between TC and NLR, weak positive correlation with PLR and a weak negative correlation with lymphocyte levels. Conclusions: NLRs and PLRs were reduced due to phototherapy in term neonates, and these ratios canbe used to aid in management in term neonates with hyperbilirubinemia on phototherapy.
ASPECTS OF CANADIAN LAW CONCERNING THE ENVIRONMENT
Authors:   Principal, Dr RML College of LawResearch Scholor,Guide & co-author.Dr Sandeep Desai,Presidency University, Bangalaore., K.K Vijayalakshmi
Published: April 2023

The Researcher has worked on the aspects of the Canadian law concerning the environment, new epitome by exploring Canadian environmental protection act,1985 and 1999 along with Oldman river society v/s Canada scope of the area is limited to CEPA-1985 &1999,National Task force on the Environment & Economy in 1987.
CLINICO-EPIDEMOLOGICAL STUDY OF FACIAL MELANOSIS
Authors: Jandial Sunakshi , Dogra Devraj , Kumari Saroj
Published: April 2023

Introduction: Melanosis affecting face and neck occur from a myriad of conditions. The similar overlapping clinical, histological and dermoscopic features posses an intricate diagnostic problem for the clinician. Attempts to classify them have been partially successful. Methods: This was a prospective hospital based study conducted in a tertiary hospital over a period of one year involving 120 patients of facial melanosis. Relevant investigations including skin biopsy and patch testing were done wherever required. Results: Study sample ranged from nine to 60 years with maximum number of patients in 21-40 years of age. Females predominated in the study. Most common diagnosis was melasma followed by pigmented contact dermatitis, periorbital melanosis, lichen planus pigmentosus, erythema dyschromicum perstans, poikiloderma of civatte and eythromelanosis follicularis. Conclusion: There was considerable clinical, histological overlap between these clinical entities. UV exposure in melasma and lichen planus pigmentosus, exposure to allergens in pigmented contact dermatitis were the main etiological factors implicated. Key words: facial melanosis, melasma, pigmented contact dermatitis, lichen planus pigmentosus.
Students' Mathematical Literacy Ability in Comparative Material Viewed from Students' Reasoning Ability
Authors: Utami Namira Putri , Purwati Heni , Aini Aurora Nur
Published: April 2023

AbstrakPenelitian ini bertujuan untuk mendeskripsikan kemampuan literasi matematika pada materi perbandingan berdasarkan kemampuan penalaran siswa. Metode penelitian yang digunakan yaitu deskriptif kualitatif dengan sampel siswa kelas VII G SMP Negeri 1 Bodeh yang dipilih dengan cara purposive sampling. Subjek penelitian sebanyak 6 siswa dengan 2 siswa yang memiliki kemampuan penalaran tinggi, 2 siswa yang memiliki kemampuan penalaran sedang, dan 2 siswa yang memiliki kemampuan penalaran. Instrumen utama dalam penelitian ini adalah peneliti sendiri dan instrumen pendukung yang digunakan adalah soal tes dan pedoman wawancara. Teknik pengumpulan data yang digunakan dalam penelitian ini yaitu dengan tes, wawancara, serta dokumentasi untuk mengabadikan hal-hal penting yang berkaitan dengan penelitian. Teknik analisis data dilakukan dengan 3 tahapan yaitu reduksi data, penyajian data, dan penarikan kesimpulan. Teknik pemeriksaan keabsahan data menggunakan triangulasi sumber. Hasil penelitian menunjukkan bahwa siswa dengan kemampuan penalaran tinggi berada pada level 5 kemampuan literasi matematis, siswa dengan kemampuan penalaran sedang berada pada level 4 kemampuan literasi matematis, dan siswa dengan kemampuan penalaran rendah berada pada level 2 kemampuan literasi matematis. AbstractThis study aims to describe the ability of mathematical literacy in comparative material based on students' reasoning ability. The research method used was descriptive qualitative with a sample of grade VII G students of SMP Negeri 1 Bodeh selected by purposive sampling. The research subjects were 6 students with 2 students who had high reasoning ability, 2 students who had medium reasoning ability, and 2 students who had reasoning ability. The main instruments in this study are the researchers themselves and the supporting instruments used are test questions and interview guidelines. The data collection techniques used in this study are tests, interviews, and documentation to capture important matters related to the research. Data analysis techniques are carried out in 3 stages, namely data reduction, data presentation, and drawing conclusions. The technique of checking the validity of the data uses source triangulation. The results showed that students with high reasoning ability are at level 5 mathematical literacy ability, students with medium reasoning ability are at level 4 mathematical literacy ability, and students with low reasoning ability are at level 2 mathematical literacy ability.
Development of Rocky E-Module Wolfram Mathematica to Improve Students' Critical Thinking Skills
Authors: Dewi Grahita Sukma
Published: April 2023

Kemampuan berpikir kritis perlu untuk dikembangkan dan ditingkatkan karena merupakan keterampilan yang harus dikuasai di abad 21. Namun pada kenyataannya, kemampuan berpikir kritis masih rendah. Hal ini didukung oleh beberapa penelitian yang menyebutkan bahwa tingkat kekmampaun berpikir kritis siswa di Indonesia masih tergolong rendah. Dalam penelitian ini bertujuan untuk mengembangakn suatu media pembelajaran berupa e-modul berbantuan wolfram mathematica yang layak (valid) digunakan dan mnegetahui tingkat efektivitas e-modul tersebut. Penelitian ini menggonakan model pengembangan ADDIE dengan tahapan analisys, design, development, implementation, evaluation. Media yang dikembangkan sebelum diuji cobakan divalidasi oleh validator ahli media dan ahli materi dengan hasil penilaian ahli media sebesar 84% dengan kategori “Sangat Baik” dan hasil penilaian ahli materi sebesar 88% dengan katagori “Sangat Baik” dengan artian e-modul layak (valid) digunakan dalam proses pembelajaran. Dari hasil uji coba penggunaan e-modul dapat disimpulkan bahwa e-modul efektif dalam meningkatkan kemampuan berpikir kritis siswa dilihat dari ketuntasan belajar siswa ≥ 75%, hasil belajar kelas eksperimen lebih baik dari kelas kontrol, dan terjadi peningkatan kemampuan berpikir kritis yang dihitung menggunakan uji N-Gain AbstractCritical thinking skills need to be developed and improved because it is a skill that must be mastered in the 21st century. But in reality, critical thinking skills are still low. This is supported by several studies which state that the level of critical thinking skills of students in Indonesia is still relatively low. This study aims to develop a learning media in the form of an e-module assisted by tungsten mathematica that is feasible (valid) to be used and to know the level of effectiveness of the e-module. This study uses the ADDIE development model with the stages of analysis, design, development, implementation, evaluation. The media that was developed before being tested was validated by media expert validators and material experts with the results of the media expert assessment of 84% in the "Very Good" category and the results of the material expert assessment being 88% in the "Very Good" category, meaning that the e-module is feasible (valid). ) is used in the learning process. From the results of trials using e-modules, it can be concluded that e-modules are effective in improving students' critical thinking skills seen from students' learning mastery 75%, experimental class learning outcomes are better than control classes, and an increase in critical thinking skills is calculated using the test N-Gain
Academic Procrastination, Self-Efficacy, and Task Value of Pre-Service Biology Teacher During Online Learnings
Authors: Astutik Fuji , Bukhori Baidi , Rahmatika Rizqi
Published: April 2023

Academic procrastination, frequently linked to low self-efficacy and poor assignment performance, is more likely to occur when learning online. This study aims to reveal the level of academic procrastination, self-efficacy, and assignments by semester, areas of academic procrastination, and reasons for delaying assignments, as well as the relationship between academic procrastination, self-efficacy, and task value. This study uses a quantitative approach through a cross-sectional exploratory study. The sample in this study was semester 1, 3, 5, and 7 students who were taken through a stratified random sampling technique. Utilizing the survey method was the data collection methodology. The level of students is described using frequency distribution descriptive data. To use regression analysis to explain the connection between academic procrastination, self-efficacy, and task value. The reasons for procrastination were analyzed qualitatively. According to the findings, pre-service biology teachers who participated in online learning exhibited moderate levels of academic procrastination (37.8%), self-efficacy (39.1%), and task value (29.9%). More than half of the pre-service biology teachers polled stated they would prefer to postpone doing summaries of four pages of foreign language homework over twelve pages of Indonesian homework. Compared to creating a summary of the subject, more than half of biology education students said they would rather put off making a mind map. Reasons for postponing assignments varied among students. Furthermore, in academic procrastination, there is a negative simultaneous association between self-efficacy and task value.
ADVANCED CHATBOT DEVELOPMENT TO IMPROVE STUDENT LITERACY AND NUMERACY SKILLS
Authors: Faqih Muhammad Izzatul , Adriyani Zuanita , Listiyani Laily
Published: April 2023

The literacy and numeracy skills of prospective teacher students are still in the very low category. This is an indication that the opportunity to increase students' literacy and numeracy skills is still very high. The purpose of this study was to measure the increase in literacy and numeracy in science learning using the Advanced Chatbot media. This type of research is an experimental research with a pretest-posttest group design technique. The research was conducted at the students of Elementary School Teacher Education, Walisongo State Islamic University, Semarang and University of Sarjanawiyata Tamansiswa Yogyakarta, with a total of 57 students. The data acquisition technique used a test instrument. The literacy and numeracy indicators used are based on the achievements developed by PISA 2015 namely knowledge and skills to 1) use various numbers and symbols related to basic mathematical concepts to solve practical problems in various contexts of everyday life; and 2) analyze the information displayed in the form of graphs, tables, and charts. Then use the interpretation of these results to predict and make decisions. The test instrument was declared valid as seen from the level of difficulty and the suitability of the items. The results of the analysis show the mean value of n-Gain is 0.32 in the medium category. This means that there is an increase in student literacy and numeracy in science learning assisted by advanced chatbot media. In conclusion, advanced chatbots can be used as an alternative media for science learning which can effectively improve students' literacy and numeracy skills.
Research on dynamic characteristics of marine engine transmission system
Authors: Sun Wei
Published: April 2023

As the main component of marine engine, the transmission system often produces serious vibration and noise, which will significantly affect the performance and service life of the driving mechanism. In order to provide reasonable structural design basis for marine engine transmission system, the dynamic characteristics under different working conditions were studied in this paper. A simplified rectangular structure was applied to express the instantaneous motion state model of the chain link, and the equation was expressed according to Euler kinematics theory. The MNF (modal neutral file) model was derived by making the links and pins flexible parts, and the rigid flexible coupling model of the transmission system was established based on ADAMS. Since invalid constraints were adjusted and replaced, the transmission system model could be simulated and calculated precisely under the conditions of different tension, spindle rotation speed and driving sprocket teeth number. By changing the model parameters through the single variable method, the variation rules of transmission ratio, spindle radial force, transmission ratio deviation and maximum transient stress of chain link were obtained respectively. According to the design and construction of vibration test platform, the simulation result was verified, and the spectrum response results of the chain drive system were obtained. The results show that the rigid flexible coupling model can achieve high simulation accuracy in the chain drive system. Reasonable tension and sprocket teeth number can not only reduce the amplitude, but also reduce the fluctuation of output torque and transmission ratio.
Peptide Amphiphiles for Pharmaceutical Applications
Authors: Fuertes-Llanos Mayra Alejandra , Gómara Maria José , Haro Isabel , Sánchez-López Elena
Published: April 2023

During the last few decades, several efforts have been made towards developing
biocompatible materials. Among them, peptide amphiphiles (PAs) constitute a novel
nanotechnological strategy used in the field of biomedicine since they can provide tissue-
specific binding and localization. PAs possess several regions combining hydrophobic
and hydrophilic areas that are able to self-assemble in aqueous media, forming different
tertiary nanostructures able to interact with cellular membranes. Moreover, these
molecules can be tuned by incorporating collagen, lipids, or fluorescent markers. In addition,
they can also be used as carriers in order to encapsulate active compounds for drug
delivery showing promising features in this area. In this review, the self-assembled structures
of PAs as well as their pharmacological applications have been summarized. Furthermore,
their use as drug delivery systems has been highlighted and the latest advances
in this field have been reviewed.
The Combined Effect of Curcumin and Crocin on the Reduction of
Inflammatory Responses in Arthritic Rats
Authors: Rashidi Khodabakhsh , Korani Mitra , Nemati Houshang , Shahraki Raheleh , Korani Shahla , Abbasifard Mitra , Majeed Muhammed , Jamialahmadi Tannaz , Sahebkar Amirhossein
Published: April 2023

Background:

The present study evaluated the anti-arthritic impact of combined crocin
and curcumin on Adjuvant Induced Arthritis (AIA) in rats.

Methods:

The arthritis model was induced in rats by injecting Complete Freund’s adjuvant (CFA)
into the right hind paw and was subsequently treated with crocin and curcumin. Evaluation of anti-arthritic activity was carried out using paw swelling, hematological parameters, biochemical parameters, inflammatory cytokines, and histopathology of rats.

Results:

The results showed increased paw swelling, increased serum markers levels, including
CRP, RF, ALP, ALT, and AST, and inflammatory cytokines (ILlβ and TNFα) along with histology
changes (cartilage and bone degradation) in arthritic rats when compared to the normal group.
Crocin, curcumin and crocin + curcumin administration at different doses (especially combination
at 40 mg/kg and 30 mg/kg, respectively), as well as MTX, revealed a suitable therapeutic effect on
AIA rats. Moreover, both phytochemicals and their combination at different doses showed effective anti-arthritic effects owing to their anti-inflammatory effects

Conclusions:

Crocin and curcumin, either alone or in combination, can be a suitable treatment modality for rheumatoid arthritis.
Early-Life Lead Exposure: Risks and Neurotoxic Consequences
Authors: Bjørklund Geir , Tippairote Torsak , Hangan Tony , Chirumbolo Salvatore , Peana Massimiliano
Published: April 2023

Background:

Lead (Pb) does not have any biological function in a human,
and it is likely no safe level of Pb in the human body. The Pb exposure impacts are a
global concern for their potential neurotoxic consequences. Despite decreasing both the
environmental Pb levels and the average blood Pb levels in the survey populations, the
lifetime redistribution from the tissues-stored Pb still poses neurotoxic risks from the
low-level exposure in later life. The growing fetus and children hold their innate high-susceptible
to these Pb-induced neurodevelopmental and neurobehavioral effects.

Objective:

This article aims to evaluate cumulative studies and insights on the topic of Pb
neurotoxicology while assessing the emerging trends in the field.

Results:

The Pb-induced neurochemical and neuro-immunological mechanisms are likely
responsible for the high-level Pb exposure with the neurodevelopmental and neurobehavioral
impacts at the initial stages. Early-life Pb exposure can still produce neurodegenerative
consequences in later life due to the altered epigenetic imprints and the ongoing
endogenous Pb exposure. Several mechanisms contribute to the Pb-induced neurotoxic
impacts, including the direct neurochemical effects, the induction of oxidative stress and
inflammation through immunologic activations, and epigenetic alterations. Furthermore,
the individual nutritional status, such as macro-, micro-, or antioxidant nutrients, can significantly
influence the neurotoxic impacts even at low-level exposure to Pb.

Conclusion:

The prevention of early-life Pb exposure is, therefore, the critical determinant
for alleviating various Pb-induced neurotoxic impacts across the different age
groups.
Efficacy of auditory integration therapy (AIT) on plasma syntaxin1A (STX1A) levels and amelioration of behavioral, social, and sensory symptoms in children with autism spectrum disorder (ASD)
Authors: Al-Ayadhi Laila Yousif , Elamin Nadra Elyass , Halepoto Dost Muhammad , Alhowikan Abdulrahman Mohammed
Published: April 2023

Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder. Previous research reported the beneficial effects of Auditory Integration Training (AIT) on a considerable range of behavior and learning problems. Limited studies examined the association between AIT and biological biomarkers in autistic subjects. Therefore, this study aims to examine the effect of auditory integrative training on the plasma syntaxin1A protein (STX1A) level and also to assess its impact on behavioral, social, and sensory symptoms in autistic children, using a sandwich enzyme-linked immunoassay (ELISA). Total scores of the Childhood Autism Rating Scale (CARS), Social Responsiveness Scale (SRS), and Short Sensory Profile (SSP) were calculated before one month and three months after AIT for all participants. Results show that the plasma level of STX1A was significantly increased immediately, one month, and three months after AIT (P<0.05). Moreover, Pearson correlation (r) values between STX1A levels before and after AIT shows strong and positive significant correlations between STX1A levels before AIT and immediately after AIT (r=0.594, p=0.01) and one month after AIT (r=0.819, p=0.01). Additionally, our results revealed that behavioral, social, and sensory symptoms were significantly improved in terms of disease severity three months after AIT (p<0.05). The study supports the usefulness of AIT as a therapeutic intervention to improve some measures of ASD such as symptoms. It may also induce the up-regulation of STX1A in plasma in ASD subjects. However, Additional research, on a larger size population, is necessary to evaluate the AIT effect on behavioral and social changes in ASD children, and the up-regulation of STX1A.
Increase Wine Tourism in Spain from Chinese Tourists
Authors: Wang Liao Wei , Aguilera Dolores Sánchez
Published: April 2023

In recent years and especially after the world pandemic COVID-19, the tourism sector is undergoing great changes as a result of travelers looking for unique and outdoor products to enjoy different experiences, involving new trends in tourism, especially in non-traditional destinations, and changing the needs and attitudes of tourists. In this sense, the tourist is currently more and more motivated by sensations in the search for new experiences. In this context, in which the experience is a fundamental objective, some tourist modalities such as wine tourism, already emerge as practices aimed at satisfying the new demand after the 1990s world widely. Nevertheless, this paper is present the current Chinese tourist flows after the pandemic and their relevant motivations in the growing demand for slow tourism, breaking the traditional stereotype of what we think are their demands, and presenting the possibility of wine tourism in small and middle-scale places like Priorat of Catalunya and Ribeira Sacra of Galicia, both situated in Spain. The main objective of this study is to research the development of a friendly campestre and natural wine and food local supplies, their interesting up-downs historic paths, their impressive "heroic" geographic sceneries such as the big contrast of mountains against rivers in these two still developing their international names wine regions of Spain: Priorat and Ribeira Sacra, also analyzing the high acquisitive power and potential demands of wine tourism for Chinese outbound tourists for this two regions, to identify the adjustments that must be made in the plannings and applications in these two specific wine regions, and serving as examples for others still not well known international wine regions to be developed for Chinese tourists or even Asian tourists for Europe and the rest of the world.
СЕТИ 5G: ЭВОЛЮЦИЯ К ОТКРЫТОЙ СЕТЕВОЙ АРХИТЕКТУРЕ ЧАСТЬ 1. ОСНОВНЫЕ ЭЛЕМЕНТЫ КОНЦЕПЦИИ ОТКРЫТЫХ РЕШЕНИЙ ДЛЯ СЕТЕВОЙ ИНФРАСТРУКТУРЫ 5G
Authors: Коган С.С.
Published: April 2023

При развертывании сетей мобильной связи 5G поверх существующей или вновь создаваемой сетевой инфраструктуры операторы и провайдеры телекоммуникационных услуг заинтересованы во внедрении открытых решений, позволяющих использовать на одной сети аппаратные платформы и программное обеспечение разных производителей. Этот интерес стимулируется также внедрением на сети 5G новых, облачных, технологий с широким использованием центров хранения и обработки данных. В цикле статей даны определения основных элементов (часть 1) и представлен обзор работ по стандартизации (часть 2) открытых решений и интерфейсов для сетевой инфраструктуры 5G.
Способы получения и изучение свойств полимерных пленок на основе гелей поливинилового спирта, преобразованных 1-(2 пиридилазо)-2 нафтолом
Authors: Фарус О.А.
Published: April 2023

В работе приведены результаты исследований, посвященных вопросам получения полимерных пленок на основе гидрогелей поливинилового спирта, модифицированных 1-(2 пиридилазо)-2 нафтолом. Исследование направлено на поиск эффективного способа синтеза влагостойких полимерных пленок со стабильными оптическими свой­ствами. Оценены влагостойкость полученных материалов путем определения времени их деформации в водной среде, изучены спектры поглощения в диапазоне длин волн 190–800 нм. Установлено, что любой из выбранных способов синтеза приводит к увеличению влагостойкости пленок, но при этом может происходить существенное изменение их спектральных характеристик. Отмечена перспективность использования материалов, полученных воздействием высоких температур (100 °C) в течение 30 мин.
Риск оценки соответствия качества воды установленным требованиям
Authors: Белоусов Р.А. , Назарова А.А. , Розенталь О.М.
Published: April 2023

Стандартные правила оценки показателей качества природной воды предусматривают проведение измерений с погрешностью, которая часто соизмерима с абсолютным значением контролируемой величины. Вследствие этого возникают риски ошибочной оценки соответствия/несоответствия природной воды установленным требованиям безопасности и качества. Предложена простая методика количе­ственного исследования такого риска. Показано, что его максимальный уровень ограничен 50%, когда управленческие решения прини­маются в условиях полной неопределенности. Предложен способ учета рассматриваемых рисков при разрешении спорных ситуаций на основе имеющихся доказательств.
USING TELEGRAM TO IMPROVE ENGLISH PRONUNCIATION OF HIGH SCHOOL STUDENTS
Authors:   Universitas Islam Syekh-Yusuf, Sudarmaji Imam , Maulida Siti Izza ,   Universitas Islam Syekh-Yusuf
Published: April 2023

This study investigated the use of social networking site Telegram in improving students’ pronunciation of eleventh grade students in one of senior high school in Tangerang, Indonesia. A total of 24 students were taken as the sample in the current study. Non-randomized one class pretest-posttest design was used in the study. Using quasi experimental research one-class pretest-posttest design, the students in the experimental class completed the process through Telegram. The tests and questionnaires were used to collect the data. In order to test whether there was an improvement within the class, the hypothesis was tested using the t-test and obtaining the gain scores. The result showed that the pronunciation of students was improved. They were interested in learning through the media, wanted to learn new things, and active throughout the learning process. Based on the percentages, students’ posttest showed that the pronunciation of students was improved after using social networking site Telegram. Moreover, this research also found that the evaluation of learning model was good, the students’ learning motivation was very good, and made a good class atmosphere in the experimental class throughout the learning process by using social networking site Telegram.
GENERATING IDEAS TO WRITE NARRATIVE THROUGH ILLUSTRATED POEM : INDONESIAN EFL STUDENTS’ EXPERIENCES
Authors:   Universitas Islam Negeri Sumatera Utara, Nabilla Ega Viorenti , Fithriani Rahmah ,   Universitas Islam Negeri Sumatera Utara
Published: April 2023

Writing has become the most important skill to learn for English as a foreign language (EFL) students. However, students often have difficulty getting ideas when writing narrative stories. This article aims to offer suggestions on using pictorial poetry to generate ideas for writing narrative texts as an innovation in learning English. Pre-tests and written assignments were used for data collection in this qualitative study. Participants' narrative texts were evaluated using adaptations from the Teaching for Better Educators Model (2019) and Advanced English Books by the Ministry of Education and Culture Research and Technology (2020) Narrative Analytical Rubric. Seven students from a state senior high school in Percut Sei Tuan, Indonesia, became the participants. The results showed that participants had difficulties in getting ideas during the pre-test but were able to come up with writing ideas after being stimulated using the pictorial poem "Unicorn." The participants' narrative texts also meet the requirements for narrative text organization, sensory details, and proof of revision and editing as described in the Narrative Analytical Rubric. However, the use of visual stimuli can only help in generating story ideas; further teaching is needed to produce qualified narrative texts. It can be concluded that pictorial poetry can be used as a learning resource for teaching narrative writing, so educators should consider this to help students learn.
UNLOCKING THE SECRETS OF VLSs ENGLISH DEPARTMENT STUDENTS AT UNIVERSITAS PGRI SUMATERA BARAT
Authors:   Univesitas PGRI Sumatera Barat, Yelliza Yelliza , Siska Siska
Published: April 2023

The objectives of this study were obviously to determine the most and least commonly used vocabulary learning strategies by the students. In addition, it was to identify the reasons behind their use of these strategies. An explanatory mixed-method research design was employed, with the population consisting 3 translation classes in English Department Students at Universitas PGRI Sumatera Barat in the odd semester, academic year 2019/2020. Data was collected through questionnaires and interviews, using the Vocabulary Learning Strategies Questionnaire which contained 40 statements. Descriptive statistics, such as means and standard deviation, were used for statistical analysis. The findings indicated that determination strategies (M=3.32) were the most frequently used vocabulary learning strategies by students, while social consolidation strategies (M=1.82) were the least used. Furthermore, the study explored the reasons behind the students' most and least used strategies. It was found that the students' preferred strategy of using dictionaries to find the meaning of new words was due to its ease and effectiveness, whereas the least used strategy of interacting with native speakers to find new words was limited by the availability of context and vocabulary knowledge.
The Portrait of Scientific Approach Assisted by Video in EFL Reading: Participatory Action Research
Authors:   UIN Kiai Haji Achmad Siddiq Jember, Wahono Suparwoto Sapto
Published: April 2023

Learning English cannot be separated from reading skills. Explanatory text is one type of English text in reading skills. This text introduces students to natural events or phenomena that are often studied by students of natural science programs. The purpose of this study is to improve the students' ability to read explanatory texts with a scientific approach using video. This study used classroom action research with cycle stages consisting of planning, implementation, observation, and reflection. The data collection techniques used were observation with field notes, documents, and written tests. Findings suggest that the scientific approach using video improved the students' skills to read explanatory texts. It was proved that the average result of the pre-cycle was 70 and the average result of the first cycle was 75.
Energy and Electrical Audit
Authors: Raj Aakash , Nagappan Dr. Beemkumar
Published: April 2023

fficiency is essential for the supply and use of energy throughout the sector through optimal management. Energy management and energy audit to reduce costs by saving energy for various types of industries, institutions, hospitals, residential areas, etc. KIIT University is one of such progressive University that for see the future that it hired EnerVision, a Private Third-Party company to conduct such an audit, and we as a Team of BEE Certified Energy auditors, accepted this proposal and conducted an audit in first week of March. The Key findings 0f the audit and the general procedure, Equipment’s, Methodology and Synopsis is presented in the report. These management and audit discover areas where there is electricity waste and implement efficient and appropriate energy use through effective energy management and auditing methods, the environment too can be protected. Energy and money can be saved without affecting the natural and quality work performed in each department. This article briefly explains the process of energy audits and energy management in and around buildings.
Effect of Mono-Dispersed Solids Slurry Characteristics on Horizontal Bends
Authors: Mishra Sai Swapnesh , Mahapatra Kalpanta
Published: April 2023

Abstract: Erosion in multiphase flow due to the effect of solid particles is a key factor in wearing of industrial pipelines. In recent years, industries are using Computational Fluid Dynamics to study erosion wear in pipelines. Researchers have investigated various factors that affect the erosion of pipelines including particle size, velocity, coating material, fluid viscosity, region of pipe (bends/fittings convex or concave), etc. This paper investigates the effect of various slurry parameters on the rate of material erosion in the pipeline, under different sets of operation conditions. Silica sand (density= 2650 kg/m3 ) slurry was considered for the simulations, mixed in water at different volumetric concentration (12%, 24% and 36%), with an inlet velocity of 2.74 m/s and 3.56 m/s. The particle size was considered constant at 225µm, 450µm and 675µm, respectively. Simulations are done in ANSYS-FLUENT software under Eulerian two-phase model with k-ε approach. Results showed that the erosion rate followed the trend of increasing with an increase in all the above mentioned varying parameters as it varied from 8.25 mm/yr to 18.93 mm/yr. It was also hinted that as particle size reduced, the influence of velocity as a contributing parameter reduced which is explained by the fact that the mixture is leading from suspension state to colloidal state.
Laboratory Testing Pros and Cons Over Natural Grey Water and Synthetic Grey Water Testing
Authors: Chougule Sandeep , Swaminathan Dr. A. N. , Bamane Dr. P. R.
Published: April 2023

Abstract: This abstract explores the advantages and disadvantages of laboratory testing over natural grey water and synthetic grey water testing. Grey water refers to water that has been used in household activities such as washing dishes and laundry. Laboratory testing involves conducting experiments in a controlled environment using standardized protocols to measure the effects of grey water on various parameters, including chemical, physical, and biological characteristics. Natural grey water testing involves studying the effects of grey water on the environment in its natural setting, while synthetic grey water testing involves creating a standardized solution that mimics grey water's chemical composition.