bluuebunny/crossref_metadata_2025 huggingface dataset:
Lipoprotein lipase gene polymorphisms and their association with the development and severity of carotid artery stenosis
Authors: Shaker Khazaal Mahmood , Bader Hamdan Farqad , Sharhan Al-Mayah Qasim
Published: July 2023

Introduction and Aim: In developed countries, carotid artery stenosis (CAS) has a considerable impact on mortality and disability rates. Genetic risk factors for CAS have also been linked, in addition to environmental risk factors. This study sought to determine whether there may be a link between three polymorphisms in the LPL gene and the emergence of CAS.
 
Materials and Methods: One hundred and twenty participants were enrolled in this case-control study, including 60 individuals with CAS and 60 healthy subjects serving as the control group. The demographic and clinical data were collected from each participant. Whole blood samples were obtained to study the genomic DNA where a specific LPL gene fragment corresponding to the three single nucleotide polymorphisms (SNPs) rs320, rs328, and rs285 was amplified using designated primers. Restriction fragment length polymorphism analysis was used for genotyping.
 
Results: The mutant allele (C) of the rs285 polymorphism was more frequent in patients than controls (45% vs. 32.5%; OR=1.7, 95% CI= 1.01- 2.87; p=0.048). The TCC haplotype block (T allele of rs320, C allele of rs285, and C allele of rs328) was significantly more prevalent in patients compared to controls (OR= 2.0, 95% CI= 1.03-3.77, p= 0.039). On the other hand, controls (23.33%) had significantly more of the haplotype block GTG than did patients (8.33%) (OR = 0.3, 95% CI = 0.14-0.065, p = 0.002). The SNPs rs320 (D' = 0.63) and rs328 (D' = 0.61) have weak relationships with rs385.
 
Conclusion: The C allele of rs285 polymorphism could be considered a risk factor for CAS. While the haplotype block GTG was thought to play a protective role, the haplotype block TCC (T allele of rs320, C allele of rs285, and C allele of rs328) may increase the risk of CAS.
Isolation and characterization of bacteriophage targeting Enterococcus faecalis isolated from root canal infection (in vitro study)
Authors: F. Almelan Maha , Khalid Abbas Uroba , M. Al-Zubidi
Published: July 2023

Introduction and Aim: Enterococcus faecalis, a Gram-positive bacterium inhabits the human and animal intestinal tracts and the environment. E. faecalis in addition to being implicated in a wide variety of infections in humans is considered the most common threat associated with recurrent root canal treatment failures. In this investigation we aimed to characterize E. faecalis strains isolated from chronic endodontic infection and evaluate the effect of a bacteriophage for its capability to eliminate E. faecalis biofilm formation.

 

Materials and Methods: This study involved 65 chronic endodontic infection samples which were studied for the prevalence of Enterococcus faecalis. The identification of E. faecalis was accomplished by a combination of biochemical testing and the sequencing of the 16S rRNA gene. Phages isolated from cow dung samples were purified and evaluated based on their capability of preventing the development of biofilms by Enterococcus faecalis on biotic surfaces.

 

Results: Of the 65 chronic endodontic infection samples studied nineteen tested positive for the presence of E. faecalis. E. faecalis strain K3 was found to be vancomycin resistant. Biofilm development on abiotic surfaces by E. faecalis strain K3 was shown to be greatly reduced after exposure to the enterococcal phage BAG1.

 

Conclusion: This investigation shows that the E. faecalis bacteriophage BAG1 significantly decreases the growth of E. faecalis biofilm on abiotic surfaces.
Correlation of serum gamma-glutamyl transferase and serum glutathione-S-transferase with PAP smear as screening tests for cervical cancer
Authors: Sowkanthika P. , D. S. Maitreyee , D’ Almeida Joylene , A. R. Shivashankara , S. S. Avinash , Premakumari E. , M. Malathi
Published: July 2023

Introduction and Aim: Papanicolaou (PAP) smear has been the test of choice in screening for cervical cancer. However,  biochemical parameters such as enzymes have been analyzed for their use in screening,  diagnosis and prognosis of cervical cancer and cervical pre-malignancy. In our study we aimed to analyse serum gamma-glutamyl transferase (GGT) and Glutathione–S- transferase (GST) in screening for cervical cancer and correlate these activities with PAP smear results.
 
Materials and Methods: Women who tested positive (cases) or negative (controls) for PAP smear were the subjects of this study, and activities of GGT and GST were assayed in serum samples. 
 
Results: Serum GST was significantly lower among the cases when compared to controls (p=0.005) while serum GGT did not differ significantly between the two groups.  There was no significant correlation between GGT and GST activities both in cases and controls.
 
Conclusion: Serum GST showed statistically significant difference between newly diagnosed cases of cervical intraepithelial neoplasia and women testing negative for cervical intraepithelial neoplasia during screening. Further evaluation of serum enzymes as biomarkers for screening, diagnosis, and prognosis, with larger sample size and comparison between healthy controls, cervical premalignant lesions and cervical cancer are required. This would go a long way in establishing enzymes as sensitive biomarkers of cervical cancer.
Effectiveness of conventional management and Carica papaya on influencing wound healing: A systematic review and meta-analysis
Authors: Siva Sathya , Sekar Madhanraj , Prakash V. Surya , J. Titus , Arifullah Mohamed Fazulah Mohammed , V. Suriyakala
Published: July 2023

Protease enzymes found in the Indian papaya, also called Carica papaya, are known to have de-sloughing and wound healing properties. It was found that Carica papaya applied to a lesion enhanced phagocytic cell killing of bacteria. Green papaya is rich in papain and chymopapain, two potent digestive enzymes that can break down dead tissue and have anti-inflammatory properties. To compare the effectiveness of conventional and Carica papaya management in wound healing the systematic review and meta-analysis is conducted. Based on PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines, a systematic review is conducted. While using the search terms ‘Diabetic foot ulcer, conventional management, wound healing, Carica papaya’ in the MEDLINE, Google Scholar, and PubMed databases. Carica papaya has a good beneficial effect on reducing necrosis and is frequently utilized in the management of wound healing. None of the studies have demonstrated any adverse impacts of Carica papaya on wound healing.
Effectiveness of Mirena® LNG-IUS in treating women with endometrial hyperplasia and climacteric syndrome
Authors: Teppeeva Tanzilya , Karymshakova Kanysh , Makenzhanova Meerim , Zhumabekova Altynai
Published: July 2023

Introduction and Aim: Endometrial hyperplasia (EH) is a common cause of malignant tumors and a major health risk for perimenopausal women. In this study, systemic immunological markers in women with climacteric syndrome (CS) and EH will be examined in relation to the EH treatment option Mirena® levonorgestrel-releasing intrauterine device (LNG-IUS).
 
Materials and Methods: Examining 350 premenopausal women, 84 (23.4%) were diagnosed with EH. The type of EH was identified in 84 patients using a histological study and a diagnostic curettage of the uterine cavity. In view of more severe and considerable systemic immunity abnormalities in women with CS and EH, the indirect effect of levonorgestrel's intrauterine microdose excretion on systemic immunity was examined.
 
Results: Mirena® LNG-IUS has an indirect immune-corrective effect on systemic and humoral immunity in women with EH who have a pathological climatic course. It does this by stabilizing the neutrophil pool, activating the receptor function, and stabilizing the absorption and metabolic activity of neutrophilic phagocytes in the humoral system.
 
Conclusion: Due to the pathological progression of menopause and the appearance of EH, alterations in women's reproductive system during this period led to a significant decrease in the signs of CS after the first month of using Mirena® LNG-IUS.
Hypervitaminosis D induced hypercalcemia leading to coma: A case report
Authors: K. Agrawal Bimal , Mathew Manu , Kalia Sahil , Tongar Aditi
Published: July 2023

An elderly female presented with abdominal pain, vomiting and easy fatigability. Her sensorium gradually declined and became comatose. She was on Methotrexate, folic acid and prednisolone for her rheumatoid arthritis. The neurological examination and neuroimaging did not contribute in making the diagnosis. It is challenging to diagnose a metabolic cause of coma. Once diagnosis is established, the management becomes easier. On detailed investigation, she was found to have severe hypercalcemia with corrected serum calcium level being 18.2 mg%. Serum vitamin D level was also high, 150 ng/ml. On probing for detailed history, it was revealed that she had been taking a weekly dose of 60,000 IU of vitamin D for nearly 5 years. In recent times, association of various diseases has been reported with vitamin D deficiency. Vitamin D supplementation seems justified in this patient considering her age and the fact that she had rheumatoid arthritis; she was also taking corticosteroid. The recommended dose of vitamin D has been 400–800 IU/day. However, it is often prescribed at a dose of 60,000 IU/week, and sometimes patients self-medicate. There are no guidelines available for prescribing vitamin D at such a strength. Though safety of vitamin D has been established, vitamin D toxicity can occur sporadically with serious consequences. This was managed with intravenous fluids and diuretics. The patient also required subcutaneous calcitonin and low dose of corticosteroid, in addition to a session of haemodialysis for her hypercalcemia. The patient’s sensorium gradually improved as her calcium level returned to normalcy.
The Learnability of Cognitive and Metacognitive Reading Strategies in Moroccan Higher Education: A Quasi-experimental Study
Authors: Msaddek Mohammed
Published: July 2023

Constituting a substantive part of my unpublished Doctoral Dissertation that was defended in 2015, the present study probes into the impact of (meta) cognitive reading strategy training on Moroccan EFL students’ strategic processing of textual content. In principle, it draws parallels between the (meta) cognitive strategic act implemented by the English department first-semester university learners (Control group: N=50; Experimental group: N=63) before the metacognitive strategy intervention and the one enacted by these two targeted groups after the intervention. To put to the test this straightforwardly stated assumption, such research instruments as reading comprehension texts, reading strategy training, and retrospective questionnaire were resorted to for eliciting the relevant data. The results reveal that the delivery of explicit (meta) cognitive strategy training is deemed a contributive factor in culminating in improved (meta) cognitive strategy application among the treatment group. Thus, a panoply of recommendations that are germane to education and research as well as a range of limitations which confronted the current research study are tacitly put forth.
Reactivity of curcumin and curcuminoid β-diketones with o-aminothiophenol: synthesis of 1,5-benzothiazepines
Authors: Martínez Carlos A. , Sanz Dionisia , Claramunt Rosa M. , Elguero Bertolini José
Published: July 2023

Four new 1,5-benzothiazepines were synthesized by reaction of o-aminothiophenol with curcumin and curcuminoid β-diketones, in methanol and in acetic acid. The mechanism involves a Michael addition on the CC double bond affording a benzothiazepine with two pendant groups, an aryl group adjacent to the sulfur atom and a 1-phenylethanone adjacent to the NH of the seven membered ring. 1D and 2D multinuclear NMR (1H, 13C, 15N, 119F) in solution and 13C and 15N NMR in solid state proved to be essential to elucidate the structures of these benzothiazepines, in particular their tautomerism. A secondary product has been identified that has the structure of a benzothiazole.

Keywords: curcumin; β-diketones; aminothiophenol; 1,5-benzothiazepines
Adaptation of the adrenal medulla to stress: Pathophysiological implications
Authors: Alcides Olivos-Oré Luis , Arribas-Blázquez Marina , Barahona Gomariz Mª Victoria , Llorente Sáez Celia , Rodríguez Artalejo Antonio
Published: July 2023

There is no life without stress and without adaptation to stress there is no life. Adaptation to stress requires the intervention of the nervous system for proper coordination and adjustment of the intensity of the response to stressful stimuli (stressors). The sympathetic nervous system is primarily responsible for rapid adaptive responses to stress, of which the classic example is the “fight or flight” response. This response is mediated by adrenaline secreted from the adrenal medulla and noradrenaline released both from the adrenal medulla and postganglionic sympathetic neurons. However, inadequate sympathetic activation, both in duration and intensity, may be at the origin of several “stress-related” diseases (hypertension, heart failure, pain, etc.). Although the sympathetic nervous system has traditionally been viewed as a one functional unit, the idea of a differentiated contribution to the stress response between the adrenal medulla and the sympathetic neurons, also with differentiated pathophysiological implications, is gradually gaining ground.

Keywords: stress; sympathetic nervous system; adrenal medulla; chromaffin cell; stress-related diseases
Importance of experimental surgery for training of the surgeon and development of clinical surgery
Authors: Rodríguez Montes Jose Antonio
Published: July 2023

Advances in medicine in general and surgery in particular have been due to a great extent to animal experimentation, a practice carried out since ancient times; without their use, the scientific progress achieved to date would not have been possible. Scientific surgery is based on observation, in clinical research and in experimental research. Although experimentation can be done in humans, respecting ethical standards, usually the surgical research takes place in animals.
This text discusses the prominent role that experimental surgery plays in the training of surgeon and in development of clinical surgery.

Keywords: experimental surgery; surgeon training; surgical progress; surgery; surgical education: animal experimentation
The school of pharmacy, the Complutense University of Madrid and the spanish political Transition
Authors: Cuéllar Rodríguez Santiago , Barberá Sáez José Ángel
Published: July 2023

After a brief analysis of the Spanish political transition, in this article we will try to offer a general perspective of what this process meant for Spanish society, for the university – in particular for the Complutense University of Madrid, UCM – and, finally and to a greater extent, for the School of Pharmacy of the UCM. Doing it exhaustively, also providing the corresponding documentary graphic material, would be completely outside the limits of this article, so we will stick to a few specific aspects, which we hope will be sufficient to reach a general, global, representative and consistent for this period. To do this, we will look at Antonio Doadrio López, the dean of the transition, the existence of “complementary academic subjects” imposed by the regime, the difficulties in updating the Pharmacy curriculum, the changing academic regime, the demographic and sociological aspects most relevant of students, their associations and participation, ending with the Informative Bulletin of the Faculty (BIF), where some of the chapters of that great story that was the Transition were written in fine print.

Keywords: Spanish political transition; Complutense University of Madrid; School of Pharmacy; academic curriculum; student participation; academic regimen
KAJIAN KRITIS HUBUNGAN HUKUM DAN MORAL DALAM PARADIGMA POSITIVISME HUKUM
Authors: Giyono Urip
Published: July 2023

Hukum dan Moral menjadi perdebatan akademisi sepanjang masa, khususnya dalam aliran hukum alam dan paradigma positivisme hukum. Kedua aliran ini dalam memandang hubungan hukum dan moral mempunyai perbedaan yang sangat tajam. Positivisme hukum yamg mulai berkembang pada abad ke-19 lebih mengutamakan kepastian hukum,yang menekankan pada bunyi peraturan perundang-undangan.Cara hukum yang positivistik tersebut,tidak biasa diharapkanuntuk mencapai sisi keadilan substantive.Sebaliknya Hukum Alam memandang erat hubungan antara hukum dan moral.Dalam perspektif hukum alam, hukum harus memuat prinsip-prinsip moral,sehingga hukum yang ada mempunyai kekuatan makanya sebagai hukum,yaitu keadailan.
Optimalisasi Panduan Kegiatan Magang dan Studi Independen Bersertifikat dengan Penggunaan Website
Authors: Erisa Aprilia Wicaksari  , Bogy Febriatmoko
Published: July 2023

Pengabdian kepada masyarakat ini bertujuan untuk mengoptimalisasi panduan kegiatan magang dan studi independen bersertifikat dengan penggunaan website Jurusan Manajemen Fakultas Ekonomi Universitas Negeri Semarang. Selain itu, panduan ini diharapkan dapat meningkatkan pelayanan di bidang pendidikan, sehingga akan memberikan kualitas pelayanan yang baik bagi dosen, mahasiswa, dan masyarakat.
Fault Detection and Isolation ofDCMicro-Grid
Authors: Nasare Ruchita , Garad Sakshi , Patil Sakshi , Besekar Nikita
Published: July 2023

In a microgrid, faults can lead to voltage instability, which can produce voltage sags, swells, or even a full collapse of the voltage. This may result in electrical equipment damage and interfere with the microgrid's operation. Faults can also produce safety risks including fire, explosion, or electrocution, which can endanger employees and harm equipment. By isolating or shutting down the system when a malfunction is found, the danger of harm or injury is reduced. The purpose of fault isolation and detection in a DC microgrid is to guarantee the microgrid's dependability and safety. The microgrid's flaws are found using fault detection and isolation (FDI) techniques, which are then used to isolate them so they won't influence other system components. Themicrogrid's downtime can be reduced by immediately identifying and isolating issues, ensuring a steady supply of electricity to the associated loads. Additionally, fault isolation and detection can stop problems from spreading to other system components, which can reduce the severity of the fault's harm.The purpose of this research is to identify and isolate faults that occur in DC microgrids, as well as to minimise their impact. In this project fault detection and isolation is properly done, for detecting a fault microprocessor is used which continuously monitor the values of current and voltage and for isolation of microgrid relay is used. We are successfully providing the circuit which detects the fault and isolate within the time which reduces the severity of fault and protect the healthy
Automatic Headlamp Control and Obstacle Detection
Authors: Patil Dr. Nitin S. , Pande Jagruti J. , Borse Rachna P. , Kamble Rinku M. , Niphade Pratik A.
Published: July 2023

The numberof vehicles nowadaysincreasingvery fastly and so is technology. Safety is averyprime factor and has to be considered. vehicles are fitted with lots of safety features. Automatic Upper Dipper beam control and obstacle detection also need to be installed to improve safety to the next level. Thesefeatures are mainly used in nighttime driving or foggy weather or rain. Human eyes are very sensitive to light. when the light suddenly comes in contact with the eyes after darkness, the cornea present in the eyes gets contracted. i.e., human eyes will not be able to see for a short time. it is also called light glare. a vehicle coming from the opposite side with headlight in upper mode causes blind to the driver’s eyes. Insuch cases,there are high chances of occurring an accident. So, an automatic mechanism for controlling the light upper or dipper has to be made todecrease the chances of accidents during nighttime driving. Also, sometimes the driver won’t be able to see any object in nighttime orfoggy or rainy seasons. so, a sensor-based system where obstacle detection is enabled may assist from falling into an event of a crash. these two features assure you a very safe and comfortable drive. The operatingprinciple working and design of PCB is explained in this paper
Discussão sobre a distribuição circumtropical de Cyclestheria hislopi (branchiopoda, crustacea) e implicações na paleontologia
Authors: Ferreira-Oliveira Luis Gustavo , Rohn Rosemeire
Published: July 2023

A Cyclestheria hislopi faz parte de um grupo de crustáceos límnicos com carapaça externa bivalve, denominados Conchostráceos. Seres que vivem em diversas ilhas e continentes circuntropicais são morfologicamente idênticos, porém esta enorme distribuição é discutível. As características reprodutivas e ecológicas da espécie restringem sua dispersão a corredores de água doce e muitas populações encontram-se isoladas por mares há milhões de anos. Apresenta-se a hipótese de que a C. hislopi não corresponda a uma única espécie. No caso de conchostráceos fósseis, problemas taxonômicos e paleobiogeográficos similares são muito prováveis, agravados pelo fato de serem preservadas apenas as suas carapaças externas. O presente trabalho discute o potencial de dispersão da espécie e questiona sua unidade genética, o que permite refletir sobre o potencial de as espécies fósseis similares constituírem ferramentas seguras nas reconstruções paleogeográficas e correlações estratigráficas.
HISTORIA I WSPÓŁCZESNOŚĆ LOTNICTWA TRANSPORTOWEGO W MAŁOPOLSCE
Authors: Kuck Jerzy
Published: July 2023

Celem opracowania była analiza powstania i rozwoju oraz funkcjonowania lotnictwa w Małopolsce, ze szczególnym uwzględnieniem lotnictwa transportowego od momentu jego powstania do czasów obecnych. Dokonując analizy i charakterystyki tego lotnictwa, z jednoczesnym przedstawieniem zadań, pokazano jego specyfikę oraz miejsce i wpływ na funkcjonowanie sił zbrojnych oraz gospodarki narodowej. Zaprezentowane zostały również sylwetki samolotów, ich charakterystyka, zadania i możliwości. W podsumowaniu zastosowano jedną z metod badawczych – syntezę, która pozwoliła na przedstawienie wniosków generalizujących – podsumowujących działalność lotnictwa, w tym szczególnie lotnictwa transportowego stacjonującego na terenie Małopolski.
Da'wa Narration of Matchmaking in Opor Ayam Short Film
Authors: Azzahro Fatimah , Salama Hartini
Published: July 2023

Background: The narration of women as wives in every age and culture is always conveyed using various methods. This diversity is increasingly being explored through the development of media and digital technology. Short films through the Youtube channel can also be a medium of dawah to narrate a matchmaking.

Purpose: The focus of this study is limited to how the topic of matchmaking is narrated in the short film “Opor Ayam” published by NU Online.

Design and methods: This study’s method is descriptive qualitative with verbal and visual narrative research data on the short film Opor Ayam published by NU Online in 2021. This research uses semiotics-signification theory to obtain a narrative structure for the meaning of matchmaking.

Results: The results show that the Opor Ayam film has four stages, namely equilibrium, disruption, disequilibrium and new-equilibrium as a narrative structure. The results of the discussion also show that the topic of matchmaking is conveyed as; (1) acceptable in religion, (2) must be based on religious provisions, (3) the narrative emphasizes that marriage through matchmaking is a familiarization and must be based on religion.
VALIDATION OF ANTI-BACTERIAL EFFECT OF AMALTAS (Cassia fistula, METHANOLIC EXTRACT) AGAINST SELECTED BACTERIAL STRAINS
Authors: Zubair Faiza , Riaz Naila , Khalid Iqra
Published: July 2023

Increasing prevalence of antibiotic resistance necessitates the development of more potent natural product that has no adverse effects on human health. Purpose of this study is to verify the medicinal efficacy of selected plant extract (Cassia fistula) against selected bacterial strains. For this purpose the methanolic extract of Cassia fistula (Amaltas) was employed at different concentration, temperature and pH conditions to study its antimicrobial properties against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. Results revealed that Cassia fistula showed maximum zone of inhibition (2.6mm±1.1) at 250mg/ml against Bacillus subtilis, while minimum zone (0.6mm±0.00) was observed against Staphylococcus aureus at 150mg/ml. The results for varying pH conditions reveled that Cassia fistula exhibits maximum inhibition (1.5mm±0.2) of Bacillus subtilis at pH-9 (concentration: 150mg/ml). In comparison, at 250mg/ml the observed zone measurement was maximum against Staphylococcus aureus at pH-9. The results at different temperature ranges depict that Cassia fistula effectively controls the growth of Bacillus subtilis at 120 o C (250mg/ml, zone of inhibition: 1.7mm±0.2). All the zones of inhibition were found significant according to the One way ANOVA. This results of current study strengthens the fact regarding antibacterial potential of plant extracts and proves that increasing incidence of antibiotic resistance can be reduced by introducing more natural antibacterial agents other than chemicals.
Researching Radio Audiences in an Emerging Pluralistic Media Environment: A Case for the Focus Group Discussion (FGD) Method
Authors: Margaret I. Amoakohene
Published: July 2023

The central thesis of this article is that the focus group discussion method of the qualitative research methodology has huge and largely unexploited potentials for use as a tool for audience research in a new democracy with a newly liberate media environment. It argues that the use of the method by Paul Lazarsfeld, Robert Merton and their colleagues at the Bureau of Applied Social Research at Columbia University to gauge audience responses and reactions to propaganda and radio broadcasts set the pace for its use in audience research. Through extensive use in, and adaptations to, different research environments, focus groups have demonstrated an ability to function as fully-fledged methods of data collection. The article examines literature on the history, development, and use of focus groups in many fields of study including media and communication to show that the method has advantages for audience research in a competitive media market. Through this perspective, and with reference to a number of studies carried out by the author in Ghana using this method, it recognises focus group research as an appropriate method for researching media, especially radio, audiences and recommends it to media owners.
Pull Strategy and Digital Marketing Optimization for House of Garment MSMEs as Brand Identity Enhancement by Legality Management, Company Profile and Website Making
Authors: Afwan Ihsanul , Lupiyoadi Rambat
Published: July 2023

The Covid-19 pandemic has hit various sectors including the textile industry, where raw material prices have experienced a significant spike amidst a decline in demand. One of the affected companies is Malabis, a garment house that was established in 2015 in South Tangerang. The company's B2B business model makes their brand known only by word of mouth and grows organically according to the word of mouth concept. When the pandemic started to subside, the company had to adapt from the beginning because the brand identity was relatively shabby. Implementing a pull strategy and digital marketing through social media channels such as websites, creating company profiles, and managing business legality will be a way to improve Malabis' brand identity to optimize sales. The aim of this study is enhancing brand identity to improve sales. The study will be followed through using a qualitative approach with descriptive analysis using data collection models such as in-depth interviews, observation or direct observation, and literature review based on data, facts, and findings in the field. Another thing that will certainly be carried out is starting from reviewing business model canvas, SWOT, Five Forces Model, VRIO Framework, GAP Analysis, and Pareto contributions to get the best solution to the problems being faced and trying to be solved. The research resulting in uplift in the turnover average (41.6%) compared to the previous year. Malabis MSMEs’ overall brand identity has been improved through optimizing the pull strategy and digitak marketing through Instagram channel and Website Creation
The Ideal Doctor Image in Asian Countries: A Qualitative Study of Gen Z Patient's Perspective
Authors: Rosa Ezra Yanuarista , Sugandi Mohamad Syahriar
Published: July 2023

Understanding the image of the ideal doctor from the patient's point of view is crucial for improving healthcare experiences, especially considering the phenomenon of patient dissatisfaction in Asian countries. This research adopts a multi-dimensional approach, incorporating symbolic interaction, cultural background, and communication theories to explore patients' perspectives on the ideal doctor. By examining the communication process through this lens, researchers can uncover the symbolic meanings attributed to doctors and their behaviours, shedding light on patients' perceptions of the ideal doctor. Then, by considering the cultural backgrounds among Asian countries, the research explores how cultural values, beliefs, and norms influence the image of the ideal doctor. This research is qualitative research, with an interpretive phenomenological approach. This research uses in-depth interviews, to gather patient views about the ideal doctor. To identify recurring themes and patterns, the collecting data will be coded using Atlas.it after that the result could be provide insight into the qualities, behaviours, and attributes that patients associate with the ideal doctor.
The Impact of Islamophobia on Society, Attitudes, Policies and The Youths
Authors: Azeez Ismail Adaramola Abdul , Jimoh Amidu  Adinoyib
Published: July 2023

Is Islamophobia a new marvel?. Are Islam and the Judeo-Christian West still hateful of and hostile toward each other? What has fueled the sudden rhetoric of Islamophobia in the United States of America and Europe?. After the attack of Twin Towers 9/11, Islam was being viewed as a conservative, barbaric and intolerant perspective of life. Muslim was posited as blood thirsty savages under the banner of a monolithic religion.The study aims to examine the impact of Islamophobia on society, attitudes, policies and the youths. Descriptive method with qualitative approach was used in the study. The 2016 Presidential elections of America were one of the most acrimonious and confrontational campaigns in the history of America. Extraordinary political rhetoric, outbursts in distasteful discriminatory tones, and anti-Muslim invectives blemished the campaign of United States (US) Presidential Elections of 2016. To endorse his political agenda, Donald J. Trump speciﬁcally focused upon Muslims as a grave issue, and likely toyed with the public pulses, which resulted in an unpredictable election result. Mirroring the perceived reality, media as an invention of information shapes public opinion. Media reports after 9/11 specifically underrepresented Muslim views and negatively portrayed Islamic culture. Islam was painted as a religion of discrimination, radicalization and regression by the Western media. With the advent of digital media, providing a carte blanche deserted the situation further. The rhetoric of Islamophobia dispersed hatred speech and acts of defamation on social media websites backed by the freedom of speech narrative.
Valoración diagnóstica de la escala de Alvarado modificado con ultrasonografía para apendicitis aguda en pacientes aguda en pacientes adultos hospital nacional dos de mayo 2018
Authors:   , Peña Anccasi Edith Giovanna
Published: July 2023

Objetivo: Determinar la valoración diagnóstica de la escala de Alvarado modificada con ultrasonografía para el diagnóstico de apendicitis aguda (AA) en pacientes adultos atendidos en el Hospital Nacional Dos de Mayo 2018. Material y métodos: Investigación observacional, descriptivo, transversal, retrospectivo. La muestra fue conformada por 208 historias clínicas de pacientes adultos con AA. Se calculó Sensibilidad (S), Especificidad (E), Valor Predictivo Positivo (VPP) y Valor Predictivo Negativo (VPN). Resultados: La edad promedio fue 36.6 ± 15.7 años, el 54.3% fueron varones. De acuerdo a la Escala de Alvarado modificado (EAM), el 75% presentó riesgo intermedio de AA, el síntoma y signo más frecuente fue hipersensibilidad en fosa iliaca derecha (96.6%) y rebote en fosa iliaca derecha (48.6%), respectivamente. El examen ultrasonográfico encontró AA en el 80.3%, el hallazgo más común fue disminución de peristaltismo en la zona (84.6%). La Escala de Alvarado modificado más Ultrasonografía (EAMUA) encontró AA en el 71.2%. El resultado anatomo-patológico (gold estándar) evidenció AA en el 79.8%. La EAM presentó S=89.16%, E=19.05%, VPP=81.32% y VPN=30.77%; en cambio, la EAMUA presentó S=72.29%, E=33.33%, VPP=81.08% y VPN=23.33%. Conclusión: La Escala de Alvarado modificada con ultrasonografía presenta menor utilidad clínica que la Escala de Alvarado modificada para el diagnóstico de apendicitis aguda en pacientes adultos atendidos en el Hospital Nacional Dos de Mayo 2018.
Kajian Prinsip dan Elemen Desain Arsitektur Nusantara
Authors: Ibadi Raden Mohamad Wisnu , Prijotomo Josef
Published: July 2023

Nusantara architecture ('original' Indonesian architecture) has differences and similarities compared to European Architecture. One of the reasons for this difference is the geographical and climatology conditions of Indonesia which is located on the equator line has 2 seasons, namely the rainy season and the dry season. While the European continent is located above the equator, divided into northern, western, eastern and central Europe and most European countries have 4 seasons in a year, namely spring, summer, autumn and winter. Geographical and climatology differences coupled with differences in living patterns and behavior as well as the culture of the people, cause differences in the mindset of Archipelago Architecture from European Architecture. The oral tradition left many of the noble cultural values of the Indonesian people behind the written traditions of European culture, coupled with the Dutch colonial rule that made the European mindset be practiced in the world of modern Indonesian architecture today. There is a lack of writing and research related to the Nusantara mindset which inspire this paper to examines the elements and design principles of Nisantara Architecture in an exploratory and speculative way compared to the European mindset. The objective of the research is to identify the applicability and inapplicability of design elements and principles of European-classic architecture in the Batak Karo architectural environment.
Analisis Distribusi Debit Aliran pada Pelimpah dengan Variasi Model Bangunan Peluncur
Authors: Dilaga Satria , Hardiansyah Yudi , Hamdi Fauzan , Tongeng Andi Bunga
Published: July 2023

Spillway is a structure in a dam designed to drain excess water into a downstream river. The purpose of this study was to determine the water level in the stepped and ladderless chutes and to determine the type of flow that occurs in the stepped and non-stepped chutes. The research method is a laboratory experiment and the data obtained is based on the results of observations made at the Hydraulics Laboratory of the University of Muhammadiyah Makassar. After passing through the launcher building, the water level in the 1st aperture ladder launcher is 2.7 cm, 2.9 cm in the 2nd opening, 2.9 cm in the 3rd opening. The water level in the ladderless launcher at the 1st opening is 3 cm, at the second opening is 3.5 cm, at the 3rd opening is 3.9 cm so that it can be concluded that the shape of the launcher structure influences the water level, thus the water level at ladderless launcher is larger than ladderless launcher. After passing through the launcher building, the Reynolds number on the stepped launcher with the 1st opening is 8301, on the 2nd opening is 8811, on the 3rd opening is 9061. to 3 of 26,103.
Integration of Technology in Education and its Impact on Learning and Teaching
Authors: Mdhlalose Dickson , Mlambo Gloria
Published: July 2023

This study seeks to understand the effects of technology on education: teaching and learning. All the data used in this study comes from secondary sources. Information was gathered from several sources, including peer-reviewed journal papers, published and unpublished dissertations, online and print textbooks, and encyclopaedias. Findings: Evidence on the effects of technology is contradictory, according to a review of the relevant literature. Thanks to information technology developments, classroom collaboration between teachers and students is more efficient than ever. It broadens their academic and intellectual horizons, making students more versatile in the classroom. Due to the internet's accessibility, remote learning may now be supported by technological means. Students can use search engines to conduct research. Hardware failures, software incompatibilities between home and school, or non-existent internet connections, and outdated program versions are just some of the dependability problems that students and teachers face in the classroom.  Because of developments in technology like graphical calculators, high-tech gadgets, and small cameras, dishonest students may now easily gain an edge over their classmates. Distractions in modern life may be traced back in large part to technological advancements. Students' health might be negatively impacted by excessive technology usage.
Fazedores de Cultura, Comedores de Patrimônio
Authors: Pieroni Gabriella Cristina
Published: July 2023

A expressão “fazedores de cultura” surgiu no Brasil na última década no campo da  participação social nas políticas culturais, e aponta para uma mudança conceitual que dá  protagonismo aos agentes da sociedade na produção cultural do país. Transportando esta  mudança de paradigmas para as políticas de preservação do patrimônio cultural, quem seriam  os “comedores de patrimônio”? Observou-se nos últimos anos uma forte demanda pelo  reconhecimento de práticas agroalimentares como patrimônio cultural. A partir da historicidade da  Política de Salvaguarda do Patrimônio Imaterial executada pelo IPHAN, este artigo propõe uma reflexão sobre a relação entre Estado e sociedade civil na aplicação do instrumento legal  do registro do Patrimônio Imaterial, especificamente para práticas culturais diretamente ligadas à  alimentação, sejam elas agrícolas e/ou culinárias.
Comparison of methods for correcting QT interval in athletes and young people: A systematic review
Authors: Mahendran Shehane , Gupta Ishita , Davis Jason , Davis Angus J. , Orchard John W. , Orchard Jessica J.
Published: July 2023

Screening elite athletes for conditions associated with sudden cardiac death is recommended by numerous international guidelines. Current athlete electrocardiogram interpretation criteria recommend the Bazett formula (QTcB) for correcting QT interval. However, other formulae may perform better at lower and higher heart rates (HR). This review aimed to examine the literature on various QT correction methods in athletes and young people aged 14−35 years and determine the most accurate method of calculating QTc in this population. A systematic review of MEDLINE, EMBASE, Scopus, and SportDiscus was performed. Papers comparing at least two different methods of QT interval correction in athletes or young people were included. Quality and risk of bias were assessed using a standardized tool. The search strategy identified 545 papers, of which 10 met the criteria and were included. Nine of these studies concluded that QTcB was least reliable for removing the effect of HR and was inaccurate at both high (>90 beats per min [BPM]) and low (<60 BPM) HRs. No studies supported the use of QTcB in athletes and young people. Alternative QT correction algorithms such as Fridericia (QTcF) produce more accurate correction of QT interval at HRs seen in athletes and young people. QTcB is less accurate at lower and higher HRs. QTcF has been shown to be more accurate in these HR ranges and may be preferred to QTcB for QTc calculation in athletes and young people. However, accurate QTc reference values for discrete HRs using alternative algorithms are not well established and require further research.
Negative frequency dependent selection unites ecology and evolution
Authors: Christie Mark R. , McNickle Gordon G.
Published: July 2023

From genes to communities, understanding how diversity is maintained remains a fundamental question in biology. One challenging to identify, yet potentially ubiquitous, mechanism for the maintenance of diversity is negative frequency dependent selection (NFDS), which occurs when entities (e.g., genotypes, life history strategies, species) experience a per capita reduction in fitness with increases in relative abundance. Because NFDS allows rare entities to increase in frequency while preventing abundant entities from excluding others, we posit that negative frequency dependent selection plays a central role in the maintenance of diversity. In this review, we relate NFDS to coexistence, identify mechanisms of NFDS (e.g., mutualism, predation, parasitism), review strategies for identifying NFDS, and distinguish NFDS from other mechanisms of coexistence (e.g., storage effects, fluctuating selection). We also emphasize that NFDS is a key place where ecology and evolution intersect. Specifically, there are many examples of frequency dependent processes in ecology, but fewer cases that link this process to selection. Similarly, there are many examples of selection in evolution, but fewer cases that link changes in trait values to negative frequency dependence. Bridging these two well‐developed fields of ecology and evolution will allow for mechanistic insights into the maintenance of diversity at multiple levels.
Exploring the impact of hippocampal sclerosis on white matter tracts and memory in individuals with mesial temporal lobe epilepsy
Authors: Zanao Tamires A. , Seitz‐Holland Johanna , O'Donnell Lauren J. , Zhang Fan , Rathi Yogesh , Lopes Tátila M. , Pimentel‐Silva Luciana Ramalho , Yassuda Clarissa L. , Makris Nikos , Shenton Martha E. , Bouix Sylvain , Lyall Amanda E. , Cendes Fernando
Published: July 2023

Objective

To investigate how the presence/side of hippocampal sclerosis (HS) are related to the white matter structure of cingulum bundle (CB), arcuate fasciculus (AF), and inferior longitudinal fasciculus (ILF) in mesial temporal lobe epilepsy (MTLE).

Methods

We acquired diffusion‐weighted magnetic resonance imaging (MRI) from 86 healthy and 71 individuals with MTLE (22 righ‐HS; right‐HS, 34 left‐HS; left‐HS, and 15 nonlesional MTLE). We utilized two‐tensor tractography and fiber clustering to compare fractional anisotropy (FA) of each side/tract between groups. Additionally, we examined the association between FA and nonverbal (WMS‐R) and verbal (WMS‐R, RAVLT codification) memory performance for MTLE individuals.

Results

White matter abnormalities depended on the side and presence of HS. The left‐HS demonstrated widespread abnormalities for all tracts, the right‐HS showed lower FA for ipsilateral tracts and the nonlesional MTLE group did not differ from healthy individuals. Results indicate no differences in verbal/nonverbal memory performance between the groups, but trend‐level associations between higher FA of visual memory and the left CB (r = 0.286, P = 0.018), verbal memory (RAVLT) and ‐left CB (r = 0.335, P = 0.005), ‐right CB (r = 0.286, P = 0.016), and ‐left AF (r = 0.287, P = 0.017).

Significance

Our results highlight that the presence and side of HS are crucial to understand the pathophysiology of MTLE. Specifically, left‐sided HS seems to be related to widespread bilateral white matter abnormalities. Future longitudinal studies should focus on developing diagnostic and treatment strategies dependent on HS's presence/side.
2D MXenes Embedded Perovskite Hydrogels for Efficient and Stable Solar Evaporation
Authors: Arshad Naila , Irshad Muhammad Sultan , Asghar M. Sohail , Alomar Muneerah , Tao Junyang , Shah M. A. K. Yousaf , Wang Xianbao , Guo Jinming , Wageh S. , Al‐Hartomy Omar A. , Kalam Abul , Hao Yabin , Ouyang Zhengbiao , Zhang Han
Published: July 2023

Solar evaporation is a facile and promising technology to efficiently utilize renewable energy for freshwater production and seawater desalination. Here, the fabrication of self‐regenerating hydrogel composed of 2D‐MXenes nanosheets embedded in perovskite La 0.6Sr 0.4Co 0.2Fe 0.8O3−δ (LSCF)/polyvinyl alcohol hydrogels for efficient solar‐driven evaporation and seawater desalination is reported. The mixed dimensional LSCF/Ti3C2 composite features a localized surface plasmonic resonance effect in the polymeric network of polyvinyl alcohol endows excellent evaporation rates (1.98 kg m−2 h−1) under 1 k Wm−2 or one sun solar irradiation ascribed by hydrophilicity and broadband solar absorption (96%). Furthermore, the long‐term performance reveals smooth mass change (13.33 kg m−2) during 8 h under one sun. The composite hydrogel prompts the dilution of concentrated brines and redissolves it back to water (1.2 g NaCl/270 min) without impeding the evaporation rate without any salt‐accumulation. The present research offers a substantial opportunity for solar‐driven evaporation without any salt accumulation in real‐life applications.
Reproductive late effects after hematopoietic stem cell transplant in pediatric, adolescent, and young adult cancer survivors
Authors: Appiah Leslie C. , Moravek Molly , Hoefgen Holly , Rotz Seth , Childress Krista , Samis Jill , Benoit Janie , Rodriguez‐Wallberg Kenny , Anazodo Antoinette
Published: July 2023

Reproductive late effects after hematopoietic stem cell transplant can have a significant impact on cancer survivors’ quality of life. Potential late effects include gonadal insufficiency, genital graft‐versus‐host disease, uterine injury, psychosexual dysfunction, and an increased risk of breast and cervical cancer in patients treated with total body irradiation. Despite guidelines, screening and treatment are not standardized among at‐risk patients. Provider barriers include lack of knowledge of at‐risk therapies and evidenced‐based guidelines. Patient barriers include a reluctance to report symptoms and lack of awareness of treatment options. System barriers include inefficient implementation of screening tools and poor dissemination of guidelines to providers who serve as the medical home for survivors. This review guides the clinician in identifying and managing reproductive late effects after hematopoietic stem cell transplant to improve outcomes.