bluuebunny/crossref_metadata_2025 huggingface dataset:
THE MINING INDUSTRY: AN INFORMATION BASIS FOR CHANGES IN GOVERNMENT REGULATION
Authors:   Ukrainian Academy of Printing, Shtangret Andriy , Shliakhetko Vitaly ,   Ukrainian Academy of Printing, Mandzinovska Khrystyna ,   Ukrainian Academy of Printing
Published: May 2022

The availability of mineral resources, in the context of intensifying globalization processes and growing technological gap between countries, remains important for economic development and national security, but complicating the process of extraction and competition in resource markets requires improved government regulation. Within each individual enterprise, complex problems of technological renewal in order to increase the efficiency of extraction of mineral resources while preserving the natural environment and achieving national interests cannot be solved. The aim of the study was to analyze the main performance indicators of mining enterprises with further delineation of the essence of crisis processes and the formation of an information basis for timely changes in government regulation of this key sector of the national economy. To characterize the crisis processes in the mining industry, the following methods were used: induction and deduction, comparison and systematization – in the study of current trends in the volume and economic efficiency of mining; synthesis and analysis – to determine the dynamics and characteristics of changes in the number of enterprises, the volume of sales, the number of employees and the size of the final financial results of mining enterprises in terms of certain economic activities; morphological analysis – to outline the content of crisis processes and determine the impact of key factors; graphic – for visual presentation of theoretical and methodological material; abstract-logical – for theoretical generalizations and conclusions of the study. The generalization of official analytical data and positions of experts forms a general idea of the processes in the Ukrainian mining industry. The results of the analysis revealed: reduction of the number of enterprises, in particular large and medium-sized ones with fragmentation of economic potential and reduction of the ability to compete with multinational corporations; a significant decline in sales of strategically important minerals for our country; reduction in the number of employees, in particular to coal miners; deterioration of financial performance in 2020, including losses. It is substantiated that the obtained results are the basis for changes in state regulation, which should be focused on the protection of national interests on the basis of sustainable development and social responsibility with the creation of favorable conditions for achieving the goals of mining enterprises.
THE ROLE OF SELF-MOTIVATION IN A MANAGER'S PROFESSIONAL ACTIVITY
Authors:   Poltava State Agrarian University, Sazonova Tetiana , Boghdanova Valeriia ,   Poltava State Agrarian University, Proskura Olgha ,   Poltava State Agrarian University
Published: May 2022

The article was devoted to defining a role of self-motivation in the success professional activity of a manager, which operating in the modern business environment. In our opinion, it was worth paying attention to the formation and development of self-motivation in the organization’s management, because an effective leader – a ideal, a «reference point» for the rest personnel. The purpose of the article was to determine the role of self-motivation in the professional activities of a manager in a modern organization, as well as the foundations for its development. Self-motivation in the managerial life and professional activity was seen as the main means of achieving personal and organizational goals, progress. Both, hard skills and soft skills are important in the professional activity of a manager. The article describes the differences between hard skills and soft skills. There are 13 soft skills of a modern successful manager: transparency; effective communication; effective listening; consistency and reliability; appreciation and encouragement of teamwork; desire to achieve goals; developed emotional intelligence; ability to reward and demonstrate recognition; readiness for change and ability to manage change; ability to resolve conflicts; ability to make decisions and responsibilities; capacity building and team motivation; high level of self-motivation, as well as their characteristics. An attempt to made a form a «happy seven of self-motivation», which includes: values; setting life, professional goals, in accordance with the values; self-activation, self-control, self-discipline; emotional intelligence and sensitivity; ability to set priorities and decompose goals, objectives; reward; proactivity and positivity. Thus, the basis of self-motivation was outlined. It was emphasized that the manager in the further professional activity should create and promote values, which are connected with organization’s corporate culture. At the same time, corporate values must meet the needs (physiological, safety, belonging, respect, self-expression) and feelings of personnel, otherwise the leader, no matter how much he sets his own example, will not be able to achieve self-motivation skills in subordinates. As a result, the relationship between the level of managerial self-motivation and his efficiency, as well as staff loyalty, sustainability and competitiveness of the organization was established.
INTENSITY OF HUMAN CAPITAL DEVELOPMENT IN THE REGIONS OF UKRAINE
Authors:   Ivan Franko National University of Lviv, Pryymak Vasyl , Vyshnevska Stefania ,   Ivan Franko National University of Lviv, Trach Andri ,   Ivan Franko National University of Lviv
Published: May 2022

The article substantiated the need to use the methods of multidimensional statistics to assess the intensity of human capital development. Scientists' approaches to assessing the level of human capital development have been studied and the impossibility of using the order of generalized indicators measured in the scale to assess the intensity of development of this capital has been substantiated. To perform this assessment, it is proposed to use the methods of multidimensional statistical analysis and calculate specially designed chain and basic integrated pace indexes of development, which are a generalization of indicators of chain and base growth coefficients on multidimensional time series. The method of assessing the intensity of development of human capital of the region, which consists of two steps, is considered. At the first step, the primary indices of the rate of development of human capital are calculated, and on the second – the integral pace indices of its development. Moreover, the priority of primary indicators and the division of these indicators into stimulants and destimulators are taken into account. Using the method considered in the work, the value of chain and basic integrated pace indexes of human capital development in Ukraine and its regions for the period 2013–2019 was calculated. The results of the calculations showed that in Ukraine and most of its regions in 2014, compared to the previous year, the level of human capital development decreased, which may be the result of Russian military aggression in Crimea and eastern Ukraine. In the future, by 2017, the value of this generalized indicator increased and then began to decline again. The basic integrated pace index of human capital development for Ukraine in 2019 compared to 2013 was 1.06. The value of this indicator is more than one for this period was observed in 18 regions of Ukraine. The results of the analysis should be used by regional and national management bodies to develop a strategy for the development of regions, improve the distribution of state financial resources, and increase the level of human capital development in these regions.
THE ROLE OF SCIENCE PARKS IN THE FORMATION OF THE NATIONAL INNOVATION SYSTEM
Authors:   Dniprovsky State Technical University, Prysvitla Oksana
Published: May 2022

The essence, main tasks, and purposes of science parks are highlighted in the article as one of the effective means of improving innovation development and the peculiarities of their functioning in Ukraine. The state does not often pay much attention to the national innovation system, and innovation becomes a business. Aside from the fact, business rarely needs to innovate in the production process if the government has protectionist policies. However, in recent years, there has been a tendency towards the growth of national innovation systems in the conditions of globalization development. The main problem is that countries with developing economies can either try to build their innovation system, expanding this chain of "education/science – business state" or remain a consumer of the products of foreign innovation systems. The development of science parks in Ukraine has become a powerful impetus for understanding the essence of innovation, innovation activity, innovation process, and national innovation system in the scientific and educational community. The article defines the legal principles of the organization and operation of science parks and considers the provisions of the current legislation that promote the development of their activities as a structural element of the innovation economy. However, weak state institutions, unfavorable environment for innovative business hinder the disclosure of entrepreneurial potential, create obstacles to the commercialization of innovation and its impact on GDP growth.The problems of carrying out the innovative activity in Ukraine and the characteristical activity problems of science parks are determined. Unequivocally that science parks can be divided into three models: American (USA, UK), Japanese (Japan) and mixed (France, Germany), each of which has its characteristics. Considering that any progressive change in a certain way is derivative of the corresponding scientific basis, the urgent problem is to determine the role of science parks in the formation of the innovative economy of Ukraine, to assess the possibilities for their strengthening and progress.
TO THE PECULIARITIES OF THE ACTIVITY OF FARMS IN ZHYTOMYR REGION
Authors:   Vasyl Stefanyk Precarpathian National University, Sachovskyi Igor
Published: May 2022

Characteristic features of the proposed article were as follows. First, the characteristics of the place and, accordingly, the role of farms in the agro-industrial complex of Zhytomyr region are relatively detailed, which found its expression, in particular, in the fact that data on production volumes in farms of this type in absolute terms. This significantly expands the range of required, calculated values. In our case, the relationship between the volume of production of the most important subsectors of agriculture, such as crop production and animal husbandry. In addition, it made it possible to determine the share of farms in total agricultural production in the region as a whole and in terms of these subsectors. In the context of the above, it is not least important that the consideration of the role and place of farms was not limited to this, it was detailed, for some reason (insignificant share of livestock products), giving in one of the tables data on the share of major species crops, in particular wheat, barley, sunflower, potatoes, etc. Directly in the article this is more fully reflected. Secondly, in a certain sense, the peculiarity of the article is that in the process of analyzing the efficiency of farms – in our case, Zhytomyr region – the main emphasis was placed on the indicators that are decisive in this regard. This is the level of profitability of the main types of agricultural products, both crop and livestock products. Together with the indicator of the structure of crop rotations, it gives a more or less complete idea of the level of efficiency of each individual farm. Moreover, it probably reflects all the main aspects of the functioning in this case of farms of this type. One of the most important indicators that determine the level of profitability of certain types of agricultural products is perhaps not so much the absolute value of costs as their structure. It is given and considered separately in one of the tables. Moreover, this is a complex table, without regard to its division into cost structures in crop or livestock subsectors. And, thirdly, it was clear and, perhaps, even necessary that the author considered it expedient to significantly detail the specifics of the crop sub-sector of farms in Zhytomyr region mainly by grouping them by size of agricultural land.
Sentiment Analysis
Authors: Puig Megan
Published: May 2022

This sentiment analysis analyzes settlers' negative and apathetic comments in reaction to various media sources about the Coastal GasLink Pipeline and Wet'suwet'en land defenders. A counterargument is made against each comment using the knowledge gained from taking SOC 540.
La formación de profesores: un modelo complejo y transdisciplinario
Authors: Settati Ayoub , Guzmán Ibarra Isabel
Published: May 2022

Este artículo comparte avances de una investigación sobre formación de profesores desde una perspectiva del pensamiento complejo y la transdisciplinariedad. Particularmente, se ofrecen resultados de un momento investigativo que muestra un acercamiento a las percepciones de los profesores sobre complejidad y transdisciplinariedad, para tal fin se utiliza como estrategia teórica y metodológica la noción de “tercer espacio”. Metodológicamente, se describen cuatro ciclos de investigación-acción-formación que, en estrategias de formación de profesores, religan docencia e investigación en la construcción de procesos formativos y en el análisis de práctica docente. Como resultados previos se presentan avances que develan percepciones y preconcepciones de profesores empleando el enfoque del tercer espacio; así como el diseño del modelo de formación de profesores y los primeros resultados de su implementación mediante una estrategia de formación docente que religa a la complejidad y la transdisciplinariedad. Se concluye en la trascendencia del modelo de formación y su aplicación en la estrategia de formación de profesores. Asimismo, en la importancia que tiene el enfoque educativo del tercer espacio al acercarlo, desde la dimensión de tercero incluido, a las nociones de complejidad y transdisciplinariedad con que cuentan los profesores.
Teselando el plano con polígonos convexos
Authors: Podestá Ricardo A.
Published: May 2022

En este articulo damos un panorama sobre la clasificación de los embaldosados del plano euclídeo por copias de un único polígono convexo (teselados monoedralesconvexos). Primero mostramos que el teselado con polígonos regulares sólo es posible con triángulos, cuadrados y hexágonos, hecho ya conocido por los antiguos griegos, y que si el polígono es no-convexo entonces hay infinitos teselados posibles. Así, nos enfocamos en teselados convexos con polígonos no-regulares. Primero mostramos que cualquier triangulo o cuadrilátero tesela el plano. Después mostramos que un polígono que tesela el plano debe tener 6 lados o menos. A continuación, nos ocupamos de los hexágonos y mostramos que solo hay 3 familias distintas de hexágonos convexos que teselan el plano. Finalmente consideramos el caso de los pentágonos que es mas delicado, cuya clasificación completa pudo terminarse muy recientemente en 2017. Mostramos que hay solo 15 familias distintas de pentágonos que teselan el plano
Prevalence of irritable bowel syndrome: A comparison between rural and urban settings in Bangladesh
Authors: Ghosh Dilip Kumar , Nath Mukta , Biswas Amar , Khondakar Moahammad Faiz Ahmad , Ghosh Chanchal Kumar
Published: May 2022

Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder. The prevalence of irritable bowel syndrome (IBS) varies from 4% to 20% in different Asian nations.
Objective: This community-based study was aimed to find out the prevalence of IBS in rural and urban setting in Bangladesh using Rome-III criteria.
Methods: This cross-sectional study was conducted with 3500 respondents aged 18 years and above in both rural and urban communities of Bangladesh. The respondents were interviewed using a validated questionnaire in a door-to-door survey. A Rome III criterion was used for diagnosis of IBS. IBS was further classified as constipation predominant, diarrhoea predominant, mixed and un subtype. Statistical analysis was performed with Statistical Package for Social Sciences (SPSS), version 17.0.The level of significance was set at pd” 0.05.
Results: The study population consisted almost equal percent respondents from urban (50.1%) and rural (49.9%) community. Among the respondents, 55.06% was male and 44.94% female. Overall prevalence of IBS 7.2% (95% CI, 6.39-8.10) and majority of the participants were associated with IBS belongs to age group 31-40 years with mean age 39.9%. The prevalence of IBS-C, IBS-D, IBS-M, IBS-U were 0.48%, 1.3%, 4.6%, and 0.8% respectively. In rural setting, the prevalence of IBS was 6.5%, (95% CI, 5.46-7.78) and in urban was IBS 7.8% (95% CI, 6.71-9.23). In this study, the prevalence of IBS was higher in males i.e. 57.2% in rural and 52.9% in urban compared with 42.8% in rural and 47.1% in urban females.
Conclusion: In conclusion, the prevalence of IBS in urban 7.8% and rural 6.5% among Bangladeshi population. The result of the study suggests that IBS is a major health issue among these respective populations.
Bangladesh Med Res Counc Bull 2021; 47(1): 70-77
Antimicrobial Effect of Syzygium cumini Extract Against Methicillin Non-Susceptible Staphylococcus aureus
Authors: Towhid Syeda Tasneem , Alam Mahbub Ul , Asaduzzaman Muhammad , Sagor Md Shahjalal , Mahmud Mohammad Asheak , Samad Mohammed Abdus
Published: May 2022

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of infections in Community- Associated (CA) as well as Hospital-Associated (HA) settings. Identification of new antibacterial agents from natural sources takes the forefront in research.
Objectives: The aim of the present study was to identify the resistance pattern of S. aureus in the clinical samples causing disease in Dhaka city, molecular typing of the methicillin non-susceptible S. aureus isolates and identifying new herbal components with anti-microbial effect against S. aureus.
Methods: We screened total of 78 clinical specimen of various nature (pus, urine, tracheal aspirate, conjunctiva and wound swab) with confirm S. aureus infection between March 2018 to October 2018. The specimen were cultured on mannitol salt agar to isolate S. aurues, which were later tested for antibiotic resistance according to disc diffusion method. The MRSA isolates were confirmed with PCR and typed for SCCmec element to know the distribution of hospital-associated and community-associated strains. Finally, the MRSA isolates were cultured in the presence of leaf extract and fruit extract of Syzygium cumini for observing the antibacterial potential.
Result: A total of 12 isolates of S. aureus were found to be non-susceptible to methicillin, 34%, 25%, 17% out of these were from pus, blood and urine respectively and 8% isolates were from wound swab, conjunctiva and tracheal aspirates each. Out of methicillin non-susceptible isolates, 25% and 16% were HA-MRSA and CAMRSA respectively, as seen from PCR analysis of the SCCmec gene cassette of the S. aureus genome. The rest of the 59% of the isolates were untypable. Overall, higher concentration of leaf and fruit extract reduced the optical density of MRSA culture and reduced bacterial growth in drop plate significantly.
Conclusion: Dhaka population has S. aureus with varying sensitivity against methicillin, which needs further characterization by molecular epidemiology methods.
Bangladesh Med Res Counc Bull 2021; 47(1): 82-89
ESBL Genes, blaTEM, blaOXA, and blaSHV in Poultry Gut Bacteria: An Endemic Public Health Burden in Bangladesh
Authors: Nahar Shamsun , Urmi Umme Laila , Ali Tamanna , Rumnaz Adity , Haque Tanjum Ara , Ara Bayasrin , Shah Alam Mohammed , Md. Mosaddek Abu Syed , Islam Salequl
Published: May 2022

Background: In Bangladesh, the poultry industry contributes a significant role in the food sector. A vast amount of antibiotic is used as prophylaxis and growth promotion factors in farms. These unconcerned uses of antibiotics ultimately generate resistant bacteria affecting substantial adverse consequences on human health. Extended-spectrum b-lactamase (ESBL) genes are responsible for inactivation of antibiotics containing b-lactam ring, namely, penicillin, cephalosporins, monobactams, and carbapenems.
Objectives: This study was designed to analyse the distribution of three ESBL genes and associated antimicrobial susceptibility profile of poultry gut bacteria.
Methods: This study was designed to analsze the distribution of three ESBL genes and associated antimicrobial susceptibility profile of poultry gut bacteria. Poultry feces were collected and cultured on cysteine lactose electrolyte deficient (CLED) agar and Salmonella-Shigella (SS) agar to differentiate various isolates based on colony characteristics. Identification of the isolates was made by convention biochemical tests, analytical profile index (API-20E), and 16S rRNA sequence analysis. Antibiotic susceptibility test was done by disc diffusion method using 17 antibiotics from seven groups. Subsequently, polymerase chain reaction (PCR) was employed with a specific primer to identify respective ESBL genes (blaTEM, blaSHV, blaOXA). All data were analysed by SPSS.
Results: A total of 113 isolates were identified from 85 poultry feces tested. Most of the bacteria belonged to Enterobacteriaceae family, notably Proteus spp., E. coli, Klebsiella spp., Salmonella spp., and Enterobacter spp. Different bacteria were detected, namely, Kurthia populi, Cronobactersp, and Eikenella corrodens.   Most of the poultry isolates were resistant against more than one group of antibiotics. ESBL gene, blaTEM gene was identified most frequently (53.9%), followed by blaOXA (52.2%), and blaSHV (23%). Higher phenotypic resistance was observed in isolates carrying ESBL genes.
Conclusion: This study revealed a very high frequency of three ESBL genes with their phenotypic resistance- capacities in Bangladeshi poultry gut microbiota. Excess uses of antibiotics in local poultry farms may result in the emergence of antibiotic resistance that is imposing public health threatening in Bangladesh.
Bangladesh Med Res Counc Bull 2021; 47(2): 165-174
Insulin Resistance in Obese Adolescents at a Tertiary care hospital in Bangladesh
Authors: Parvin Roksana , Begum Suraiya , Md. Osman Hayder Mazumder Abul Basher , Jahan Ismat , Shyamaly Kohinoor Jahan
Published: May 2022

Background: Insulin resistance has evolved as an important metabolic alteration in obese children especially during adolescence. Emerging data suggest that insulin resistance in obesity play the key role in the pathogenesis of hypertension, dyslipidemia, impaired glucose tolerance, type 2 diabetes mellitus, non-alcoholic fatty liver disease and metabolic syndrome.
Objective: The aim of this study was to assess the insulin resistance status of Bangladeshi obese adolescents in hospital settings.
Methods: It was a cross sectional study done in children, aged 10 to 16 years, attending the paediatric endocrine clinic, paediatric outpatient and paediatric inpatient department, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka over a period of 15 months. Homeostasis Model Assessment of Insulin Resistance (HOMA- IR) value was obtained from fasting insulin & fasting blood glucose level to assess insulin resistance in obese and normal weight children.
Results: Among obese adolescents, 78.8% were insulin resistant in comparison to16% in non-obese adolescent. Mean HOMA-IR level of obese group were significantly higher than non-obese group (4.46±1.82 Vs 1.98±1.26, p<0.001). Insulin resistance was observed in 73.8% and 84.2% among grade 1 obese and grade 2 obese adolescents respectively. HOMA-IR showed positive correlation with BMI and waist circumference. Insulin resistance showed significant association with central obesity, puberty and acanthosis nigricans (AN).
Conclusion: In this study, insulin resistance was observed in higher frequency among obese adolescents than normal weight adolescents. Obese adolescents with central obesity, acanthosis nigricans and puberty are at increased risk of insulin resistance.
Bangladesh Med Res Counc Bull 2021; 47(2): 212-218
APLIKASI METODE GEOLISTRIK DALAM PENDUGAAN KETEBALAN LAPISAN TANAH GAMBUT (STUDI KASUS: DAERAH DI SEKITAR JL. PERDANA, KOTA PONTIANAK)
Authors: Zulfian Zulfian
Published: May 2022

ABSTRAK Tanah gambut merupakan jenis tanah yang tergolong memiliki daya dukung tanah yang lemah. Pendugaan ketebalan tanah gambut telah dilakukan dengan menerapkan metode geolistrik resistivitas. Konfigurasi yang digunakan pada metode ini yaitu konfiguruasi Wenner dengan spasi elektroda terkecil sebesar 3 m. Dalam pendugaan lapisan tanah gambut, lintasan survei geolistrik resistivitas dibuat berjumlah 2 buah lintasan dengan panjang tiap lintasan 72 m dan berjarak 15 m. Data lapangan selanjutnya diolah dan dilakukan inversi sehingga diperoleh penampang resisitivtas 2D lokasi penelitian. Dari penampang resisitivitas 2D, pada lokasi penelitian diduga memiliki rata-rata ketebalan gambut 3 m s.d. 4 m dengan nilai resisitivitas 55,3 ?m s.d. 369 ?m. Setelah lapisan gambut, mulai dari kedalaman 3 m s.d. 10 m diduga lapisan tanah lempung. Informasi ketebalan lapisan tanah gambut dapat dimanfaatkan untuk perencanaan pembangunan khusunya daerah pemukiman dalam  proses pembangunan rumah maupun gedung di Kota Pontianak. Kata  kunci— geolistrik, resisitivitas, tanah gambut ABSTRACT Peat soil is a type of soil that has a weak soil bearing capacity. The estimation of the thickness of the peat soil can be done by applying the geoelectric resistivity method. The configuration  used  in this method is the Wenner configuration with the smallest electrode spacing of 3 m. In estimating the peat soil layer, the resistivity geoelectrical survey trajectory is made of 2 tracks with a length of each  trajectory of 72 m and  a distance of 15 m. The field data is then processed and inverted to obtain a 2D resistivity cross-section of the research location. From the 2D resistivity cross section, the research location is thought to have an average peat thickness of 3 m to 4 m with a resistivity value of 55.3 ?m to 369 ?m. After the peat layer, starting from a depth of 3 m to 10 m, it is assumed to be a layer of clay. Information on the thickness of the peat soil layer can be used for development planning, especially residential areas in the process of building houses and buildings in Pontianak City. Keywords—geoelectric, resistivity, peat soil
PERSEPSI GURU SEKOLAH DASAR DALAM MENGGUNAKAN GOOGLE CLASSROM DAN SCREENCASTIFY DI ERA NEW NORMAL
Authors: Rachmawati Etika , Irianti Leni , Ijudin Mohamad
Published: May 2022

Pada masa pandemik, pendidikan menitik beratkan kepada pemanfaatan teknologi untuk meningkatkan pengetahuan dan keterampilan siswa secara terpadu. Teknologi sebagai instrumen untuk mengarahkan peserta didik menjadi manusia mandiri yang terdidik yang beriman dan bertakwa kepada Tuhan Yang Maha Esa, berakhlak mulia, sehat, berilmu, cakap, dan kreatif. Teknologi yang di gunakan dalam pengabdian ini adalah Mobile Assisted Language Learning dan memperkenalkan model pembelajaran baru yaitu Google Classroom Model. Pemberlakuan model pembelajaran baru ini menuntut guru untuk senantiasa kreatif dalam menerapkan teknik pengajaran. Salah satunya yaitu dengan rekaman video dengan screen castify. Berdasarkan analisis situasi dan fakta di lapangan, maka dalam pengabdian kepada masyarakat ini dapat diidentifikasi permasalahan sebagai berikut: guru-guru Sekolah Dasar di Kabupaten Ciamis belum memiliki pemahaman dalam mengimplementasikan model tersebut dalam era New Normal. Dengan demikian perumusan masalah yang bisa dirumuskan dalam kegiatan pengabdian kepada masyarakat ini adalah: apakah pelatihan ini dapat meningkatkan pengetahuan dan pemahaman guru-guru sekolah dasar dimasa pandemic COVID 19.
Pengolahan Bee Pollen Sebagai Pangan Fungsional Pada Biskuit
Authors: Anis Ulfah , Syafnil Syafnil
Published: May 2022

Bee pollen mengandung nutrisi yang sangat berguna bagi tubuh manusia. Kandungan nutrisi tersebut misalnya asam amino, serat kasar, vitamin, mineral Fe dan Zn serta antioksidan. Kandungan nutrisi tersebut memiliki fungsi masing-masing pada tubuh ketika dikonsumsi. Mineral Fe dapat mencegah anemia. Mineral Zn dapat mencegah terjadinya stunting pada anak. Kandungan lain pada bee pollen yaitu antioksidan. Antioksidan berfungsi menangkal radikal bebas. Pembuatan biskuit sebagai cemilan sehari-hari relatif mudah dan cepat. Selain itu, biskuit juga memiliki umur simpan yang lama, sehingga biskuit dapat dijadikan stok atau simpanan cemilan sehari-hari. Pengolahan bee pollen sebagai bahan substitusi dapat memberikan pengetahuan sebagai salah satu contoh pengolahan bee pollen pada produk pangan. Bee pollen yang diproduksi di Madrasah Aliyah Mambaul Ulum belum diolah menjadi produk pangan. Bee pollen yang sudah diproduksi di Madrasah Aliyah Mambaul Ulum tersebut diharapkan dapat dimanfaatkan untuk diolah menjadi produk pangan yaitu biskuit. Praktek pengolahan bee pollen di Madrasah Aliyah Mambaul Ulum menjadi bahan substitusi dalam pembuatan biskuit merupakan salah satu cara pemanfaatan bee pollen yang telah diproduksi tersebut. Praktek pembuatan biskuit dari bee pollen tersebut diikuti oleh siswa dan guru di Madrasah Aliyah Mambaul Ulum. Siswa dan guru turut yang mengikuti praktek tersebut terlihat antusias dalam membuat biskuit dari bee pollen. Hal ini menunjukkan bahwa kegiatan ini memberikan pengetahuan baru bagi siswa dan guru di Madrasah Aliyah Mambaul Ulum.
Supraorbital Endoscopic Evacuation for Traumatic Intracerebral Hematomas in the Frontal Lobe
Authors: Oh Hyuk-Jin , Hwang Sun-Chul
Published: May 2022

Objective : Traumatic intracranial hematomas have been rarely evacuated by endoscopic surgery. The frontal lobe is the usual location for the traumatic intracerebral hematoma (TICH). Endoscopic evacuation for the frontal TICHs via an eyebrow incision is to be presented as minimally invasive surgery.Methods : Thirteen patients with frontal TICHs were managed with endoscopic hematoma evacuation via eyebrow incision. After making the incision in the lateral eyebrow, a small frontal craniotomy was made, and the hematoma was evacuated under direct visualization of a rigid endoscope. No catheter was placed. Orbital rim resection, hematoma evacuation rate, surgical complications, and outcome at discharge were analyzed.Results : Men were 11 and the mean age was 54 years old (range, 27–86). Orbitotomy was performed in four patients, and no effect on the hematoma evacuation rate was observed. More than 80% of the hematoma volume was successfully removed in 10 cases. Hematoma configuration was not related to the hematoma evacuation rate. None of the patients underwent revision operation or decompressive craniectomy.Conclusion : Endoscopic evacuation of the TICHs with the supraorbital approach may be a good method to evacuate the hematoma located in the frontal base.
Complicações relacionadas à gastrostomia de pacientes em cuidado domiciliar
Authors: Santos Karllenh Ribeiro dos , Bezerra Sandra Marina Gonçalves , Viana Rosângela Lopes , Carmo Ana Paula Bezerra Pitta do , Oliveira Teresa Amelia Carvalho de , Bacelar Érika Maria Marques
Published: May 2022

Objetivos: Analisar as complicações das gastrostomias encontradas nos pacientes em cuidados domiciliares. Métodos: Estudo transversal analítico, em que se utilizou um formulário semiestruturado em 25 pacientes. Cadastrados na Gerência de Nutrição no período de agosto a outubro de 2021. Os dados foram processados e anexados numa planilha Microsoft Excel. Resultados: As complicações de pele foram: dermatites em 8%, hiperemia 4%, processo infeccioso em 4% e, relacionados ao tubo de alimentação: a saída acidental do cateter 4%, obstrução do cateter 8%; vazamento 32%; sangramento 4%. Conclusão: O presente estudo mostrou que as principais complicações estavam relacionadas a adaptação do cateter utilizado e cuidado com o manuseio, embora seja um procedimento amplamente utilizado e considerado de baixo risco, a gastrostomia ainda apresenta complicações, as quais podem ocasionar internações dos pacientes.
Giant Polyp of the Cervix - A Case Report
Authors: Schiøtz Hjalmar A
Published: May 2022

A 45-year old woman was diagnosed with a giant polyp arising from the cervix of the uterus and reaching out 4-5cms beyond the vulva. The polyp was excised with diathermy knife without complications and was benign on histological examination. At four years there has been no recurrence. Giant cervical polyps are rare, with only about 20 cases reported in the international literature. The field of giant cervical polyps is discussed.
This Is What Climate Change Looks Like: McKenzie Wark’s Post-Literary Critiques Give Equal Value to Participation
Authors: Giunta Carrie
Published: May 2022

This essay revisits a debate about literary fiction’s ability to depict the consequences of climate change. Philosopher McKenzie Wark’s 2017 essay, ‘On the Obsolescence of the Bourgeois Novel in the Anthropocene’, offers one of many critiques of climate fiction, such as Amitav Ghosh’s influential book, The Great Derangement. But while Ghosh sees a shortcoming in contemporary novels in their lack of representation of major climate events, Wark emphasises the importance of collective action, conversation, and connection, beyond the limits of literature. Since Wark’s intervention, the global School Strike for Climate in 2019 and 2020 brought more participatory post-literary forms to represent climate change. Jean-Luc Nancy’s theory of participation, that there is no mimesis without participation ( methexis), sees a tense relation between the two rather than an opposition or conflict. I argue that Wark, by not undervaluing participation, disrupts a hierarchy that privileges the imitator at the expense of the imitation. To explore this relation, I consider how the slogan ‘there is no Planet B’ forms a snapshot of our twenty-first-century mimetic condition, from which no imitative representation will save us. Can Wark expand the vision of another relational kind of femininity in her later writing to support the demand to take part in transformational action against climate catastrophe, beyond mimetic representation carried in the form of the novel?
Covid-19 Pandemi Sürecinde Eleştirel Akıl Yürütme: Arka-Plan Bilgileri ve Uzmanlık Görüşü
Authors: YAVUZ Mesut Malik
Published: May 2022

Bu çalışmada, insanları pandeminin yayılmasını önlemeye yönelik önlemlere uymaya ikna etmede zorluğa katkıda bulunan faktörler olarak arka plan bilgisi ve uzman görüşünü ele alacağım. Bu çerçevede, eleştirel ve analitik akıl yürütmenin belirli bir öneriye ikna olmak açısından sağlam gerekçeler aradığını ve eleştirel düşünmenin bir gerekçenin sağlamlığını en uygun bilgiler temelinde değerlendirmesini gerektirdiğini tartışacağım. Bu bağlamda eleştirel düşünmenin kişinin arka plan bilgisinin kapsamını genişletmesini gerektirdiği ve arka plan bilgisinin büyük ölçüde uzman görüşü ile şekillendiği görüşünü savunacağım. Ardından, pandemiye neden olan Covid-19 virüsünün yeni bir fenomen olması nedeniyle, arka plan bilgisinin belirsizliği ve özellikle pandeminin başlangıcında uzmanlar arasındaki fikir ayrılığının insanları ikna etmede zorluklara yol açtığını göstereceğim. , kim eleştirel düşünürler. Ancak bu, rasyonel gerekçelendirmenin iki yönünden kaynaklanmaktadır: veriye dayalı gerekçelendirme ve gerekçeye dayalı gerekçelendirme. Maske kullanımını önermeye yönelik bilimsel yayınlarda, sağlık otoritelerinin raporlarında, kitle iletişim araçlarında ve kamu spotlarında sunulan gerekçeler bu iki açıdan değerlendirilecektir.
The E23K Polymorphism of KCNJ11 and Diabetic Retinopathy in Northern Iran
Authors: Alidoust L. , Ajamian F. , Abbaspour S. , Sharafshah A. , Keshavarz P.
Published: May 2022

Background: Diabetic Retinopathy (DR) is one of the most severe micro-vascular complications of diabetes mellitus (DM), involving interactions between environmental and genetic risk factors. KCNJ11 gene has a key role in insulin secretion and is of substantial interest in various populations.

Methods: A population-based association of 524 T2DM patients was performed to delineate the genetic influence of KCNJ11 polymorphisms (rs5219, c.67A>G or E23K) on the risk of DR in an Iranian population. Genotyping was performed using TaqMan assay. Univariate and MLR analysis controlling for confounders was conducted to evaluate the association between rs5219 and DR.

Results: No significant difference was observed in either genotypes distribution (p = 0.83) or allele frequency (p = 0.66) between T2DM individuals with and without DR in any models of inheritance. Genotype-phenotype association showed that DR group carrying GA genotypes, a significantly higher mean age was observed compared with two other genotypes (p = 0.04). MLR analysis indicated that HbAlc with adjusted OR of 1.84 (95% CI, 1.46–2.33, p = 0.00) and first-degree relatives of family history with adjusted OR of 2.85 (95% CI, 1.45–5.58, p = 0.002) were significantly associated with DR, but the c.67A>G genotype is not an independent predictor of retinopathy.

Conclusion: Collectively, rs5219 was not associated with DR among Iranians with T2DM.
Observing the Diversity of Alleviating Manoeuvres in Cervical Dystonia
Authors: Avanzino Laura , Di Biasio Francesca , Bonassi Gaia , Pelosin Elisa , Cothros Nicholas , Marchese Roberta , Martino Davide
Published: May 2022

The alleviating manoeuvres (AMs), classically referred to as “sensory tricks” are voluntary manoeuvres that temporarily improve dystonic postures. Although self-induced application of sensory stimuli is the most common AM, clinical experience suggests that the phenomenon is more diverse, possibly reflecting the complexity of the pathophysiological mechanisms provoking dystonia. We specifically explored five different categories of AMs in patients with cervical dystonia (CD): 1) pure sensory; sensorimotor manoeuvres in which sensory input is associated with a motor output component incorporating 2) active non-oppositional, 3) active oppositional or 4) passive motion; and 5) complex motor manoeuvres. Using an ad hoc structured clinical interview, we collected data on the frequency and efficacy of each subgroup and the possible correlation with some clinical features of CD. One-hundred patients were included in this study. Seventy-five percent of patients reported at least one AM. Half of those reporting AMs acknowledged the use of different phenomenological categories of AMs. Different categories of AMs showed noteworthy differences in prevalence of use amongst CD patients, and in the relationship of frequency of use and efficacy to patient demographic and clinical characteristics. Our observational study supports the existence of different AMs that are phenomenologically different and could be related to different degrees of sensorimotor integration dysfunction. Given that AMs are probably the most efficacious, non-invasive strategy to ameliorate CD and other dystonias, accurate phenotyping and physiological exploration of their diversity may produce relevant insight for new therapeutic strategies or appraisal of existing ones.
Stem Cell-Laden Hydrogel-Based 3D Bioprinting for Bone and Cartilage Tissue Engineering
Authors: Yang Zhimin , Yi Ping , Liu Zhongyue , Zhang Wenchao , Mei Lin , Feng Chengyao , Tu Chao , Li Zhihong
Published: May 2022

Tremendous advances in tissue engineering and regenerative medicine have revealed the potential of fabricating biomaterials to solve the dilemma of bone and articular defects by promoting osteochondral and cartilage regeneration. Three-dimensional (3D) bioprinting is an innovative fabrication technology to precisely distribute the cell-laden bioink for the construction of artificial tissues, demonstrating great prospect in bone and joint construction areas. With well controllable printability, biocompatibility, biodegradability, and mechanical properties, hydrogels have been emerging as an attractive 3D bioprinting material, which provides a favorable biomimetic microenvironment for cell adhesion, orientation, migration, proliferation, and differentiation. Stem cell-based therapy has been known as a promising approach in regenerative medicine; however, limitations arise from the uncontrollable proliferation, migration, and differentiation of the stem cells and fortunately could be improved after stem cells were encapsulated in the hydrogel. In this review, our focus was centered on the characterization and application of stem cell-laden hydrogel-based 3D bioprinting for bone and cartilage tissue engineering. We not only highlighted the effect of various kinds of hydrogels, stem cells, inorganic particles, and growth factors on chondrogenesis and osteogenesis but also outlined the relationship between biophysical properties like biocompatibility, biodegradability, osteoinductivity, and the regeneration of bone and cartilage. This study was invented to discuss the challenge we have been encountering, the recent progress we have achieved, and the future perspective we have proposed for in this field.
Nanotechnology Approach for Exploring the Enhanced Bioactivities and Biochemical Characterization of Freshly Prepared Nigella sativa L. Nanosuspensions and Their Phytochemical Profile
Authors: Ali Tayyab , Hussain Fatma , Naeem Muhammad , Khan Ajmal , Al-Harrasi Ahmed
Published: May 2022

Nigella sativa is one of the most commonly used medicinal plants as it exhibits several pharmacological activities such as antioxidant, antibacterial, anticancer, antidiabetic, and hemolytic. The purpose of this study was to apply the nanotechnology approach for exploring the enhanced bioactivities of freshly prepared Nigella sativa L. nanosuspensions and the phytochemical profile of N. sativa seed ethanolic extract. In this study, we performed the biochemical characterization of Nigella sativa L. ethanolic extract through High-performance liquid chromatography (HPLC), Fourier-transform infrared spectroscopy (FT-IR), and Gas chromatography (GC), and bioactivities in terms of antioxidant, antidiabetic, antibacterial, and hemolytic activities of nanosuspension and extract were competitively studied. The results revealed that the nanosuspension of N. sativa seeds showed higher total phenolic (478.63 ± 5.00 mg GAE/100 g) and total flavonoid contents (192.23 ± 1.390 mg CE/100 g) than the ethanolic seed extract. The antioxidant activity was performed using the DPPH scavenging assay, and nanosuspension showed higher potential (16.74 ± 1.88%) than the extract. The antidiabetic activity was performed using antiglycation and α-amylase inhibition assays, nanosuspension showed higher antidiabetic potential [antiglycation (58 ± 0.912%)] and [bacterial α-amylase inhibition (18.0 ± 1.3675%)], respectively. Nanosuspension showed higher biofilm inhibition activity against Escherichia coli (66.44 ± 3.529%) than the extract (44.96 ± 2.238%) and ciprofloxacin (59.39 ± 3.013%). Hemolytic activity was performed and nanosuspension showed higher hemolytic activity than the extract as 7.8 ± 0.1% and 6.5 ± 0.3%, respectively. The study showed that nanosuspension had enhanced the bioavailability of bioactive plant compounds as compared to the ethanolic extract. Therefore, nanosuspension of N. sativa seed extract showed higher biochemical activities as compared to the ethanolic extract. This nanotechnology approach can be used as a platform for the development of combination protocols for the characterization of liquid state nanosuspensions in an adequate manner and also for therapeutic applications.
Biomaterials for Interbody Fusion in Bone Tissue Engineering
Authors: Zhang Han , Wang Zhonghan , Wang Yang , Li Zuhao , Chao Bo , Liu Shixian , Luo Wangwang , Jiao Jianhang , Wu Minfei
Published: May 2022

In recent years, interbody fusion cages have played an important role in interbody fusion surgery for treating diseases like disc protrusion and spondylolisthesis. However, traditional cages cannot achieve satisfactory results due to their unreasonable design, poor material biocompatibility, and induced osteogenesis ability, limiting their application. There are currently 3 ways to improve the fusion effect, as follows. First, the interbody fusion cage is designed to facilitate bone ingrowth through the preliminary design. Second, choose interbody fusion cages made of different materials to meet the variable needs of interbody fusion. Finally, complete post-processing steps, such as coating the designed cage, to achieve a suitable osseointegration microstructure, and add other bioactive materials to achieve the most suitable biological microenvironment of bone tissue and improve the fusion effect. The focus of this review is on the design methods of interbody fusion cages, a comparison of the advantages and disadvantages of various materials, the influence of post-processing techniques and additional materials on interbody fusion, and the prospects for the future development of interbody fusion cages.
Fibroadipogenic Progenitors Regulate the Basal Proliferation of Satellite Cells and Homeostasis of Pharyngeal Muscles via HGF Secretion
Authors: Kim Eunhye , Wu Fang , Lim Danbi , Zeuthen Christopher , Zhang Yiming , Allen James , Muraine Laura , Trollet Capucine , Vest Katherine E. , Choo Hyojung J.
Published: May 2022

Skeletal muscle stem cells, known as satellite cells (SCs), are quiescent in normal adult limb muscles. Injury stimulates SC proliferation, differentiation, and fusion to regenerate muscle structure. In pharyngeal muscles, which are critical for swallowing foods and liquids, SCs proliferate and fuse in the absence of injury. It is unknown what factors drive increased basal activity of pharyngeal SCs. Here, we determined how niche factors influence the status of pharyngeal versus limb SCs. In vivo, a subset of pharyngeal SCs present features of activated SCs, including large cell size and increased mitochondrial content. In this study, we discovered that the pharyngeal muscle contains high levels of active hepatocyte growth factor (HGF), which is known to activate SCs in mice and humans. We found that fibroadipogenic progenitors (FAPs) are the major cell type providing HGF and are thus responsible for basal proliferation of SCs in pharyngeal muscles. Lastly, we confirmed the critical role of FAPs for pharyngeal muscle function and maintenance. This study gives new insights to explain the distinctive SC activity of pharyngeal muscles.
The Future of Membrane Separation Processes: A Prospective Analysis
Authors: Favre Eric
Published: May 2022

Membrane processes are today one of the key technologies for industrial separations and are expected to play an important role in future sustainable production systems. The combination of materials science and process engineering has historically always been an essential condition to the development of new applications for membranes. The recent development of high performance nanostructured materials, together with new production technologies (such as 3D printing) and high performance computing possibilities is expected to open new horizons to membrane processes. The different challenges and prospects to be addressed to achieve this purpose are discussed, with an emphasis on the future of process industries in terms of feedstocks, energy sources, and environmental impact.
Versatile Electrochemical Synthesis of Selenylbenzo[b]Furan Derivatives Through the Cyclization of 2-Alkynylphenols
Authors: Doerner Carlos V. , Scheide Marcos R. , Nicoleti Celso R. , Durigon Daniele C. , Idiarte Vinícius D. , Sousa Martinho J. A. , Mendes Samuel R. , Saba Sumbal , Neto José S. S. , Martins Guilherme M. , Rafique Jamal , Braga Antonio L.
Published: May 2022

We report an electrochemical oxidative intramolecular cyclization reaction between 2-alkynylphenol derivatives and different diselenides species to generate a wide variety of substituted-benzo[b]furans. Driven by the galvanostatic electrolysis assembled in an undivided cell, it provided efficient transformation into oxidant-, base-, and metal-free conditions in an open system at room temperature. With satisfactory functional group compatibility, the products were obtained in good to excellent yields.