bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation of tetraethoxysilane for the production of monodisperse spherical silica particles. Part 2. Impurities and their influence on the size of the forming globules
Authors: Kamashev Dmitriy
Published: August 2023

Monodisperse spherical silica particles, as a basis for creating supramolecular 3D matrices, are currently of increasing interest due to the prospects for their wide application in the synthesis of new nanocomposite materials. At the same time, one of main problems of their large-scale synthesis is associated with the unstable behavior of tetraethoxysilane (TEOS) during hydrolysis, which leads both to the deviation of the particles from a given size and their shape from a spherical one. In this paper, on the basis of the study of tetraethoxysilane from various manufacturers, we continued to work on determining factors that can influence the process of hydrolysis of tetraethoxysilane and, as a result, the monodispersity and size of the formed particles, and also other factors. To solve this task, all TEOS samples were studied by various physicochemical methods of analysis, including Fourier IR and Raman spectroscopy, gas chromatography-mass spectrometry. As a result of the studies, we showed that the presence of di- and trisiloxanes in the system did not significantly affect the size of the formed silica particles, while significantly accelerating the rate of formation of silica spheres. Moreover, the presence of methoxyl groups in the initial silane, and an insignificant content of ethanol in the system did not affect the size stability of the formed particles. At the same time, the replacement of part of the ethoxy groups in the initial TEOS by methyl or ethyl groups, as they are not capable of participating in the hydrolysis reaction, largely contribute to the deviation of sizes of the formed silica particles from each other. The results obtained on the effect of impurities on the size of the formed silica globules are important, among other things, for understanding the processes of formation of natural supramolecular structures of silica.
Spor Lisesi Öğrencilerinin Sosyal Destek Algıları ile Geleceğe Yönelik Tutumlarının İncelenmesi
Authors: YAŞIN İsrafil
Published: August 2023

Araştırma spor liselerinde öğrenim gören öğrencilerin sosyal destek algıları ile geleceğe yönelik tutumlarını incelemek amacı ile yapılmıştır. Araştırma grubu 2022-2023 Eğitim-Öğretim yılında Muğla ilinde bulunan spor liselerinde öğrenim gören 150’si erkek ve 53’ü kadın olmak üzere 203 öğrenciden oluşmaktadır. Araştırmanın verileri arkadaştan alınan destek, aileden alınan destek ve öğretmenden alınan destek boyutlarından oluşan Çocuk ve Ergenler İçin Sosyal Destek Değerlendirme Ölçeği (Ç-SDDÖ) ile olumlu yönelim, korkulu yönelim ve planlı yönelim boyutlarından oluşan Geleceğe Yönelik Tutum Ölçeği (GYTÖ) uygulanarak toplanmıştır. SPSS 22,0 istatistik programı kullanılarak yapılan tanımlayıcı analizler ve normallik analizleri sonucunda grupların dağılımı normal olduğundan dolayı grupların karşılaştırılmasında parametrik testlerden bağımsız gruplar T-Testi ve Tek Yönlü Varyans Analizi Testi (One-Way Anova) kullanılmıştır. Öğrencilerin Ç-SDDÖ ile GYTÖ puanları arasındaki ilişkiler ise Pearson Korelasyon Testi kullanılarak incelenmiştir. Araştırma sonucunda spor lisesi öğrencilerinin cinsiyet, spor türü ve sınıf değişkenlerine göre gruplar arasında Ç-SDDÖ ve GYTÖ alt boyutlarında istatistiksel olarak anlamlı farklar tespit edilmiştir (p
Cerebroprotective effect of sitagliptin and aminoguanidine combination in disorders of cerebral circulation
Authors: Kurkin D. V. , Bakulin D. A. , Morkovin E. I. , Gorbunova Yu. V. , Strygin A. V. , Andriashvili T. M. , Sokolova A. A. , Bolokhov N. S. , Pustynnikov V. E. , Fomichev E. A. , Baskova A. V. , Polodyants S. S. , Kasparova A. V.
Published: August 2023

The aim of the study was to evaluate a cerebroprotective activity of the sitagliptin and aminoguanidine combination in rats with an acute and chronic cerebral circulation insufficiency, as well as with a traumatic brain injury.

Materials and methods. The study was carried out on male Wistar rats in 3 stages using, respectively, a model of a chronic pathology: a chronic cerebral circulation insufficiency (CCCI), as well as 2 models of the acute brain injury (BI): an acute cerebral circulation insufficiency (ACCI), and a traumatic brain injury (TBI). А CCCI was modeled by a bilateral stenosis of the common carotid arteries (by 50%), a model of a hemorrhagic stroke caused by an intracerebral injection of the autologous blood was used as a stroke, a TBI was modeled by a mechanical damage to the brain tissue. To assess the pathology course severity, the following tests were used: Adhesion test, Open field, Morris water maze test, as well as Garcia and Combs&D’Alecy scales. In the animals with an acute damage to the brain at the end of the experiment, the severity of edema of the affected hemisphere was also determined. The treatment was with sitagliptin (10 mg/kg), aminoguanidine (25 mg/kg), or a combination thereof. The obtained data were subjected to the statistical processing.

Results. In the course of the study, it was found out that the administration of a sitagliptin and aminoguanidine combination, unlike each of the components, had a cerebroprotective effect in the animals with a chronic or acute damage to the brain, reducing the severity of psychoneurological (cognitive and sensory-motor) disorders, as well as the brain edema.

Conclusion. Aminoguanidine, as an iNOS blocker, enhances the action of sitagliptin, preventing the brain edema development and reducing the neurological deficit severity (the severity of cognitive and sensory-motor impairments) in the animals with an acute and chronic cerebral circulation insufficiency.
Development of composition and technology for obtaining antimicrobial composition based on mono- and sesquiterpenoids
Authors: Lakomkina E. V. , Atazhanova G. A. , Akhmetova S. B. , Zilfikarov I. N.
Published: August 2023

The article reflects the results of the essential oils selection for the compositions with antibacterial and antifungal properties. The technology of their production is represented.

The aim of the work was the development of technology and the study structure of new essential oils compositions with antibacterial and antifungal activities.

Material and methods. The following plants have been used in the work: the herb of Hyssopus ambiguus (Trautv.) Iljin, the herb of Thymus crebrifolius Klokov, the herb of Thymus marschallianus Willd, the herb of Thymus serpyllum L., and the essential oils obtained from them. The composition of the essential oils was determined by Gas Chromatography Mass Spectrometry. The main physical and chemical parameters of the compositions were evaluated in accordance with the requirements of the Russian State Pharmacopoeia, the XIVth edition. The tests for the antimicrobial activity were carried out using the strains of Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Candida albicans ATCC 10231.

Results. Compositions with an activity against microorganisms Staphylococcus aureus, Bacillus subtilis, Escherichia coli and fungi Candida albicans have been obtained and studied. The composition based on essential oils of Hyssopus ambiguus (Trautv.) Iljin and Thymus marschallianus Willd. contained 139 components, the main ones of which are eucalyptol (6.51%) and terpinen-4-ol (1.95%). The composition of essential oils of Hyssopus ambiguus (Trautv. Iljin) and Thymus crebrifolius Klokov contained 137 components (eucalyptol (20.37%), terpinen-4-ol (7.03%), Ʈ-muurol (2.28%), γ-terpinene (2.23%), β-myrcene (2.09%), etc.). The composition of the essential oils of Hyssopus ambiguus (Trautv.) Iljin and Thymus serpyllum L. contained 149 components (the main ones are eucalyptol (7.33%) and α-terpineol (0.9%)).

Conclusion. The technology has been proposed and the structure of the essential oils compositions with antibacterial and antifungal activities has been established.
“Off-label” drugs: legal problems and socio-economic aspects of application practice
Authors: Russkikh S. V. , Tarasenko E. A. , Moskvicheva L. I. , Orlov S. A. , Tryakin A. A. , Vorobeva A. V. , Beneslavskaya O. A. , Makarova V. I. , Putilina E. A. , Utkin S. A.
Published: August 2023

The aim of the work was to analyze Russian and foreign experience in the regulation and application practice of “off-label” drugs in order to develop recommendations on the optimization of their application in clinical practice.

Material and methods. The analysis of scientific articles and legal documents of the Russian Federation and foreign countries published from 2011 to 2022 on the websites Consultant Plus, FDA, EMA, NCBI, e-library, as well as a qualitative sociological study conducted in May-August 2022 ‒ 11 in-depth interviews with experts in the field of the healthcare system of the Russian Federation.

Results. The social and economic aspects have been considered and the list of legal problems in the application practice of “off-label” drugs has been disclosed. A state analysis of the regulatory and legal framework on the drugs application practice by healthcare professionals in the absence of registered indications for “off-label” drugs use has been presented. The use of an unregistered medicinal product in the territory of the Russian Federation in everyday medical practice has been considered. The analysis of the Russian and foreign experience in regulating the use of drugs in the absence of their registration in the country, as well as the absence of registration of some indications for their prescription in the instructions for the medical use of such drugs has been also carried out. The authors have formulated the key problems of the use of “off-label” drugs in clinical practice. Based on the results of the in-depth interviews, the recommendations of the expert community on the ways to optimize the use of “off-label” drugs have been identified and concretized.

Conclusion. The results of this study made it possible to formulate recommendations for expanding the ability of specialists to prescribe “off-label” drugs treatment while maintaining a proper degree of the state control over this process: a legislative consolidation of the regional health authorities’ obligations and responsibilities on the drug provision; creating an open and transparent system for the “off-label” drugs use by patients and their legal representatives, the mandatory full information of the patient about the fact of using the “off-label” drug, as well as the risk and nature of the development of possible adverse reactions. When prescribing these drugs, the patient safety should be the top priority.
The Shape of You, or in Other Words, why Teach Entrepreneurial Awareness as a Clinical Attribute?
Authors: Marson James , Ferris Katy
Published: August 2023

Commercial law clinics are not a new phenomenon, and indeed in this very journal reports and academic commentary have been presented which identify and explore the nature, formation and operation of such clinics. However, these contributions focus on how clinics and their student volunteers can help commercial enterprises and start-up ventures with various legal issues they may encounter. Clearly, the need for such clinics and the value they provide to the students and community are immense. Where the clinical offer outlined in this report differs, and on which we hope a meaningful contribution to the body of scholarly knowledge is made, is in using a clinic setting with a simulated corporate client to operate two (elective) modules that enable the students to gain a thorough appreciation of those issues which underpin the formation and operation of a corporate structure. A simulated law firm is the setting through which the modules operate, albeit most of the tasks and issues raised in the modules would equally apply to other professions. By using the simulated client approach we are able to guide the students in helping navigate the client through every aspect of the journey of the business – its inception, the legal sector in which it will operate, its mode of incorporation, its clients and the generation of business, legal policies and issues likely to be faced in respect of running a business, its marketing and advertisement, professional body regulation and compliance, the financing of the business, and an appreciation of the stakeholders (and underlying philosophies) with whom the business and its personnel will engage. This clinical perspective allows the students to proactively develop strategies to navigate the owner through myriad complexities, whilst gaining valuable feedback regarding the efficacy of their decision-making and being empowered to adopt revisions to accommodate numerous changes in the professional, legal and financial environments. The main aim of this clinical experience (which we describe in Section 3) is to develop in the students a commercial awareness and understanding of what is required to be an entrepreneur in a modern legal service setting. This requires moulding their ‘shape’ as a legal graduate.
PENGEMBANGAN SISTEM PERSEDIAAN BERBASIS WEB PADA UMKM
Authors: Vinny Vinny , Pangaribuan Jefri Junifer , Romindo Romindo
Published: August 2023

Manajemen persediaan merupakan salah satu hal yang sangat penting bagi suatu perusahaan terutama yang bergerak di bidang jual beli barang berbentuk fisik dan memiliki variasi serta stok yang cukup banyak. Tanpa adanya manajemen persediaan, maka akan membuka kemungkinan bagi perusahaan untuk memiliki stok yang berlebih atau terbengkalaiˇ(overstock)ˇserta memungkinkan terjadinyaˇstock-outˇyang dapat menyebabkan terhentinya proses bisnis. Untuk dapat mengontrol persediaan, salah satu metode yang dapat digunakan adalah metodeˇmin-maxˇdan data yang digunakan adalah data transaksi keluar barang yang terjadi pada 26 hari terakhir. Peneliti memutuskan untuk menggunakan metodeˇmin-maxˇkarena untuk mengontrol level persediaan, diperlukan batas minimum dan maximum agar dapat menghindariˇoverstockˇdanˇstock-out.ˇPada penelitian kali ini, peneliti akan merancang sebuah sistem berbasis web yang akan membantu perusahaan dalam hal manajemen persediaan dan pengambilan keputusan dalam menentukan jumlahˇre-order.ˇPenelitian ini akan menghasilkan sistem dengan fitur untuk menjaga persediaan agar tidak terjadiˇoverstockˇdanˇstock-outˇserta menghasilkan prediksi jumlahˇre-orderˇuntuk masing-masing produk.
RANCANG BANGUN SISTEM INFORMASI KEPENDUDUKAN DAN PELAYANAN MASYARAKAT DESA SOPET KEC. JANGKAR KAB. SITUBONDO
Authors: Mahendra Yusril Haza , Baijuri Achmad , Santoso Firman
Published: August 2023

Abstrak - Penelitian ini bertujuan untuk mengembangkan aplikasi sistem informasi kependudukan dan pelayanan desa guna meningkatkan pengolahan data administrasi kependudukan di Desa Sopet, Kecamatan Jangkar. Desa tersebut saat ini masih menggunakan formulir kertas manual dalam proses pelayanan kependudukan, yang rentan terhadap kehilangan dan kerusakan data. Dalam penelitian ini, peneliti merancang dan mengembangkan aplikasi yang memungkinkan akses mudah terhadap informasi kependudukan dan meningkatkan efisiensi pelayanan masyarakat. Metode pengembangan aplikasi melibatkan tahap analisis kebutuhan, perancangan sistem, pengembangan perangkat lunak, dan pengujian aplikasi. Aplikasi tersebut mencakup fitur pencarian data yang cepat, penyimpanan data yang aman, dan kemampuan untuk menghasilkan laporan dengan efisien. Setelah pengembangan selesai, dilakukan pelatihan kepada aparat desa dan penduduk Desa Sopet mengenai penggunaan aplikasi. Hasil penelitian menunjukkan bahwa aplikasi sistem informasi kependudukan dan pelayanan desa memberikan manfaat signifikan dalam mengoptimalkan pengelolaan data kependudukan dan mempercepat proses pelayanan kepada masyarakat.
Efektivitas Isolat Nematoda Entomopatogen Steinernema sp. Produksi PPAH Kabupaten Kediri terhadap Mortalitas Larva Spodoptera frugiperda J. E. Smith
Authors: Sari Imielda Yuli  Hartika , Wagiyana Wagiyana
Published: August 2023

Spodoptera frugiperda J. E. Smith (Lepidoptera: Noctuidae) is a pest that has just entered Indonesia since 2019 and has adapted and become an important pest in corn plants. Therefore, we need a control by utilizing biological control agents that exist in nature, one of which is the entomopathogenic nematode type Steinernema sp. which has been developed by the Biological Agent Service Post (PPAH) "Sidodadi" in the Plosoklaten District, Kediri Regency. The methods used in this study were: collection and rearing of S. frugiperda pests; breeding of entomopathogenic nematodes Steinernema sp. in vivo. The application of an entomopathogenic nematode to test pathogenicity against 3rd instar S. frugiperda larvae. The application treatments used were population densities of 1.000 JI/ml, 800 JI/ml, 400 JI/ml, 200 JI/ml plus a control treatment. The study was designed with a single Completely Randomized Design (CRD) with six treatments and was repeated four times. Each replication consisted of 10 S. frugiperda larvae. Parameters observed included mortality of S. frugiperda larvae due to Steinernema sp.. Effectiveness of Steinernema sp. by calculating the LT50 value. Observation of biological symptoms of S. frugiperda infected with Steinernema sp. and calculation of the infection rate of Steinernema sp.. Data from observations were analyzed using a 5% ANOVA. If there is a significant difference, further DMRT testing is carried out. The effectiveness test was carried out by calculating the LT50 value using Finney's (1971) probit analysis. Based on observations for 120 hours, it was shown that entomopathogenic nematode PPAH isolate was effective in killing S. frugiperda larvae. PPAH isolate entomopathogenic nematode was effective in causing mortality in S. frugiperda larvae. The highest mortality value of S. frugiperda due to entomopathogenic nematode treatment was 97.5% in treatment with 800 JI/ml and 1000 JI/ml at 120 hours after application observation. The fastest LT50 value causing mortality in S. frugiperda larvae was in the 1000 JI/ml of 32.60 hours. The treatment with the longest LT50 value caused the mortality of 50% of the test insects, namely the 200 JI/ml over 95.88 hours. Observation of the infection rate showed the highest infection rate was found in the 1000 JI/ml at 24 hours after application with as many as 0.02% tails, this is because that the higher the inoculated entomopathogenic nematode population, the higher the infection rate value.
Analisis Variabilitas Total Nitrogen Tanah dengan Menggunakan Geostatistika pada Lahan Perkebunan Tebu Studi Kasus di Tanggul Kulon Kabupaten Jember
Authors: Woda Theresia Novianti , Wijayanto Yagus
Published: August 2023

Potatoes are a commodity that has high carbohydrates after rice, wheat and paddy which makes potatoes one of the most popular commodities. The high level of seed-borne pathogen infection causes decreased productivity. Tissue culture is one of the methods used to minimize the level of pathogen contamination. The acclimatization phase is a very crucial phase because at this stage it is hoped that potato plants which were previously in in-vitro conditions can adapt to the in-vivo environment. Arbuscular mycorrhizal fungi are fungi that can form a symbiosis with plants. The symbiosis that occurs is that mycorrhizae are able to produce growth hormone which can also help in carrying out nutrient uptake. This experiment was conducted using a factorial Completely Randomized Design (CRD), which consisted of two factors. The first factor is potato cultivar which consists of granola cultivar (K1) and Atlantic cultivar (K2) and the second factor is mycorrhizal dose (M) which consists of 4 levels, namely without mycorrhizal (M0), mycorrhizal dose of 1 gram (M1), mycorrhizal dose of 3 grams (M2), and mycorrhizal dose of 5 grams (M3). The experimental results were analyzed using analysis of variance (ANOVA) and if there was a significant difference, further tests were carried out using the Least Significance Diffent (LSD) test at the 5% level. Based on the experimental results, it was shown that mycorrhizal administration had a significant effect on the parameters of plant height and leaf area. The potato cultivar factor did not have a significant effect on all observation parameters. As well as the treatment of mycorrhizal factors and potato cultivars did not show any interaction on all observation parameters.
Comparison of the modified Blumgart mattress vs. interrupted suture pancreaticojejunostomy in minimally invasive pancreaticoduodenectomy
Authors: Choi Sung Hoon , Kuchta Kristine , Paterakos Pierce , Rojas Aram , Mehdi Syed Abbas , Talamonti Mark S. , Hogg Melissa E.
Published: August 2023

Aim: The modified Blumgart mattress (BM) and conventional interrupted suture (IS) methods are currently the most widely adopted pancreaticojejunostomy (PJ) techniques utilized during minimally invasive pancreaticoduodenectomy (MIPD). This study aimed to evaluate the postoperative outcomes between the two PJ techniques using robotic and laparoscopic approaches.

Methods: This was a retrospective study involving patients who underwent robotic or laparoscopic pancreaticoduodenectomy (PD) performed by two surgeons from two institutions. Surgical outcomes of the patients were compared according to the PJ techniques of robotic BM (Rob-BM), robotic IS (Rob-IS), and laparoscopic IS (Lap-IS), which were further analyzed among patients who had a soft pancreas and small pancreatic duct, while those with pancreatic ductal adenocarcinoma were excluded from the study.

Results: A total of 230 patients underwent MIPD with 63 Rob-BM, 48 Rob-IS, and 119 Lap-IS for PJ. Within the study population, clinically relevant-postoperative pancreatic fistula (CR-POPF) rates were comparable between Rob-BM and Rob-IS (6.3% vs. 10.4%, P = 0.283) and between Rob-IS and Lap-IS (10.4% vs. 7.6%, P = 0.661). Comparing patients with soft pancreas and small pancreatic duct, CR-POPF rates were not statistically different among the groups [16.0% (Rob-BM) vs. 10.5% (Rob-IS), P = 0.055, and 10.5% (Rob-IS) vs. 10.1% (Lap-IS), P = 0.543]. In the multivariable analysis for risk factors of POPF, soft pancreatic textures and periampullary pathology other than pancreatic cancer were found to be risk factors.

Conclusion: POPF rates after MIPD were not different according to the PJ methods of BM and IS when performed by skilled surgeons.
Analisis Deskriptif terhadap Profit Perusahaan X Periode 2012 – 2021 dengan Bantuan Software R Studio
Authors: Afrinda Aulia Nisa , Abdullah Ahmad Dzikrullah
Published: August 2023

Tulisan ini memuat analisis deskriptif mengenai profit perusahaan X di Jakarta Selatan menggunakan software R Studio. Profit perusahaan X merupakan laba atau  keuntungan yang diperoleh oleh perusahaan X dari hasil pengerjaan proyek permintaan klien. Analisis deskriptif pada penelitian ini merupakan analisis statistika deskriptif secara kuantitatif berupa nilai profit perusahaan X selama 10 tahun, yaitu periode 2012 – 2021 dalam satuan rupiah. Langkah pertama yang dilakukan dalam penulisan laporan ini ialah melakukan kegiatan kerja praktik selama satu bulan di perusahaan X, Jakarta Selatan untuk mendapatkan data yang diinginkan. Langkah kedua yaitu mendeskripsikan data yang didapatkan dengan melakukan uji asumsi normalitas terlebih dahulu, kemudian memulai analisis deskriptif terhadap data profit perusahaan X selama 10 tahun terakhir. Dari analisis deskriptif kuantitatif yang dilakukan menggunakan bantuan sioftware R Studio didapatkan nilai minimum, maximum, mean, median, sum, range, standar deviasi dan koefisien variansi dari data profit perusahaan X. Terakhir, didapatkan pengetahuan mengenai kondisi profit perusahaan X selama 10 tahun terakhir.
Pengaruh Tingkat Inflasi, Upah Minimum, Dan Pertumbuhan Ekonomi Terhadap Tingkat Pengangguran Terbuka Di Provinsi Bali
Authors: Aurielle Maulidya Salsabila  , Muhammad Muhajir
Published: August 2023

Tidak sebandingnya jumlah angkatan kerja dengan jumlah tersedianya lapangan kerja menyebabkan pengangguran. Isu pengangguran menjadi suatu bahasan yang sangat kompleks untuk dibahas karena berkaitan dengan indikator ekonomi yang memengaruhinya. Metrik ekonomi berikut yang memengaruhi pengangguran adalah inflasi, upah minimum, dan pertumbuhan ekonomi. Adapun tujuan dari penelitian untuk mengetahui adanya dampak tingkat inflasi, upah minimum, dan pertumbuhan ekonomi pada tingkat pengangguran terbuka di Provinsi Bali. Data yang didapatkan melalui BPS Provinsi Bali digunakan sebagai data sekunder untuk penelitian. Metode penelitian yang digunakan bersifat deskriptif dan asosiatif. Metode statistik yang sesuai dengan tujuan penelitian adalah regresi linear berganda dengan pengujian stastistik yaitu uji asumsi klasik. Hasil analisis menunjukkan variabel inflasi, upah minimum, dan pertumbuhan ekonomi berpengaruh signifikan secara simultan terhadap tingkat pengangguran terbuka di Provinsi Bali berdasarkan tujuan penelitian dan temuan analisis data yang telah diberikan. Tingkat pengangguran terbuka di Provinsi Bali secara signifikan dan positif dipengaruhi oleh upah minimum. Sementara itu, tingkat pengangguran terbuka di Provinsi Bali dipengaruhi secara negatif oleh inflasi dan pertumbuhan ekonomi.
Analisis Peramalan Jumlah Pengunjung Daya Tarik Wisata Kabupaten Bantul dengan Metode Seasonal Autoregressive Integrated Moving Average (SARIMA)
Authors: Wibowo Danang Bagus , Tuti Purwaningsih
Published: August 2023

Salah satu kabupaten di Daerah Istimewa Yogyakarta (DIY) yang memiliki obyek wisata alam yang menarik adalah Kabupaten Bantul. Obyek-obyek wisata yang ada di daerah ini mempunyai potensi yang cukup besar, diantaranya seperti obyek wisata alam, budaya, sejarah, taman hiburan, dan lainnya. Dari beragam obyek wisata tersebut menjadikan Kabupaten Bantul sebagai salah satu kabupaten yang memiliki banyak pengunjung, baik wisatawan mancanegara maupun wisatawan lokal. Akan tetapi, adanya pandemi covid-19 yang telah menyebar di Indonesia sejak awal tahun 2020, menyebabkan penurunan pengunjung obyek wisata di Kabupaten Bantul. Maka dari itu, perlu dilakukan peramalan jumlah pengunjung agar menjadi dasar penting dalam pengambilan keputusan-keputusan yang tepat untuk kedepannya. Penelitian ini dilakukan dengan menggunakan data jumlah pengunjung daya tarik wisata Kabupaten Bantul dari tahun Januari 2016 - Desember 2019. Analisis data yang digunakan untuk melakukan peramalan adalah metode SARIMA. Dari analisis tersebut didapatkan hasil untuk model terbaik yang digunakan dalam peramalan yaitu model SARIMA(2,1,0)(0,1,0) dengan nilai MAPE sebesar 13.37% dan tingkat akurasi sebesar 86.63%.
Clustering Review Pengguna Aplikasi Zenius pada Layanan Google Play Store Menggunakan Metode DBSCAN dan HDBSCAN
Authors: Handayani Fitri Dwi , Isnaini Rosyida
Published: August 2023

Kemajuan teknologi telah melahirkan suatu inovasi yaitu terciptanya aplikasi E-learning atau Edutech yang saat ini banyak diminati untuk membantu siswa dalam belajar mandiri di rumah. Pada Google play store beberapa rating dan review aplikasi memudahkan pengguna untuk mencari aplikasi dengan review terbaik. Adanya analisis rating dan review memungkinkan developer untuk menilai bagian mana dari aplikasi yang perlu difokuskan untuk perbaikan. Analisis ulasan terhadap topik ulasan dapat dilakukan dengan berbagai cara, salah satunya dapat menggunakan metode clustering. Penelitian ini bertujuan untuk mengetahui review dari sebuah aplikasi yang paling sering ditulis oleh pengguna aplikasi. Untuk mendapatkan hasil tersebut, dilakukan review clustering terhadap pengguna aplikasi e-learning di Google Play Store dengan menggunakan metode DBSCAN dan HDBSCAN. Selanjutnya untuk menilai metode mana yang terbaik untuk clustering dilakukan dengan membandingkan nilai rata-rata SC (Silhouette Coefficient) dari kedua metode tersebut. Hasil dari penelitian ini adalah rata-rata nilai SC metode HDBSCAN lebih baik dibandingkan dengan metode DBSCAN. HDBSCAN memiliki nilai SC rata-rata 0,2941, sedangkan metode DBSCAN hanya memiliki nilai SC rata-rata 0,1310.
Analisis Pengaruh Sektor Pariwisata Terhadap Tingkat Pengangguran Terbuka di Kabupaten/ Kota Daerah Istimewa Yogyakarta
Authors: Benny Banu Adjie  , Atina Ahdika
Published: August 2023

Penelitian ini dilakukan untuk mengetahui apakah terdapat pengaruh Jumlah Hotel bintang dan non bintang, Jumlah Rumah Makan yang sudah dibina, Jumlah Wisatawan Nusantara dan Mancanegara terhadap Tingkat Pengangguran Terbuka (TPT) di  Kabupaten/Kota Provinsi Daerah istimewa Yogyakarta tahun 2016 – 2020. Metode yang digunakan pada penelitian ini adalah metode regresi data panel dengan pengolahan data nya  menggunakan software RStudio dan Excel. Data panel merupakan gabungan data time series dengan cross section, setelah dilakukan beberapa beberapa uji, diperoleh model terbaik adalah Random Effect Model (REM) dengan pengaruh cross section. Selain itu diperoleh juga koefesien determinasi (R2) untuk random effect model yaitu sebesar 69.06%. Nilai tersebut menunjukan bahwa kemampuan variable independent dalam menjelaskan variable dependen sebesar 69.06% sedangkan sisanya 30.94% dijelaskan variabel lain yang tidak termasuk model. Dari hasil yang didapatkan, diperoleh kesimpulan bahwa jumlah hotel, Jumlah Restoran dan jumlah wisatawan memiliki pengaruh terhadap tingkat pengangguran terbuka di Kabupaten/Kota Provinsi DIY, dengan hasil uji overall sebesar 1.4327x10-11, lalu dari hasil uji t-statistik diperoleh hasil bahwa variable Jumlah Hotel memiliki pengaruh yang cukup baik dan positif terhadap TPT di Kabupaten/Kota di DIY, sedangkan variable Jumlah wisatawan memiliki pengaruh dan negative terhadap pengangguran terbuka di Provinsi DIY.
Penerapan Metode K-Medoids Cluster Dalam Mengelompokkan Hotel di Jakarta Berdasarkan Website tiket.com
Authors: Widyatama Athallah , Raden Bagus Fajriya Hakim Hakim
Published: August 2023

Kota Jakarta merupakan kota yang setara dengan provinsi-provinsi yang ada di Indonesia, Jakarta memiliki peran tersendiri dalam peningkatan sektor ekonomi di Indonesia. Oleh karena itu banyak perkantoran yang berada di Jakarta, selain itu dari sektor pariwisata juga menunjang perekonomian. Salah satunya hotel, juga menjadi akomodasi yang penting untuk wisatawan ataupun pebisnis. Dalam memilih hotel tentu calon konsumen memiliki kriteria tertentu seperti dari segi kelas, harga, bahkan dari penilian orang (review) yang pernah singgah di hotel tersebut, calon konsumen dapat melihat kriteria ini melalui website perhotelan. Sehingga tujuan dari penelitian ini adalah melakukan pengelompokan hotel berdasarkan kelas (bintang), review, dan harga. Pengelompokkan ini menggunakan metode ¬K-Medoids Cluster Analysis. Dari hasil analisis K-medoids yang telah dilakukan, didapatkan 3 kelompok cluster. Cluster 1 dengan karakteristik hotel kelas bawah beranggotakan 47 hotel. Cluster 2 dengan karakteristik hotel kelas menengah beranggotakan 69 hotel. Dan untuk cluster 3 dengan karakteristik hotel kelas atas beranggotakan 14 hotel.
Full Factorial Design Synthesis of Silver Nanoparticles Using Origanum vulgare
Authors: Rigopoulos Nickolas , Gkaliouri Christina Megetho , Sakavitsi Viktoria , Gournis Dimitrios
Published: August 2023

Silver nanoparticles from Origanum vulgare (Oregano) have been synthesized in the past. However, no investigation has been performed on the combined effects of independent factors that affect the synthesis. Silver nitrate and Oregano concentrations, incubation temperature and time, as well as pH can play crucial roles in synthesis. In this regard Full Factorial Design was applied. A Voigt function was fitted on the measured UV – Vis spectra. The fitting parameters of the Voigt function (peak wavelength, area, and Full Width at Half Maximum) were used as the responses. A quadratic model was fitted for the peak wavelength and area, and the pH proved the dominant factor on nanoparticle synthesis.
Comparison between Neutralization Capacity of Antibodies Elicited by COVID-19 Natural Infection and Vaccination in Indonesia: A Prospective Cohort
Authors: Nurisyah Sitti , Iyori Mitsuhiro , Hasyim Ammar Abdurrahman , Sakamoto Akihiko , Hashimoto Hinata , Yamagata Kyouhei , Yamauchi Saya , Amru Khaeriah , Zainal Kartika Hardianti , Idris Irfan , Yoshida Shigeto , Djaharuddin Irawaty , Syafruddin Din , Bukhari Agussalim , Asih Puji Budi Setia , Yusuf Yenni
Published: August 2023

(1) Background: To fight for COVID-19 pandemic, immunity against SARS-CoV-2 should be achieved not only through natural infection but also vaccination. Controversies exist about the effect of COVID-19 vaccination on previously infected persons; (2) Methods: A prospective cohort was undergone to collect sera from unvaccinated survivors and vaccinated persons--with and without COVID-19 pre-infection. The sera were analyzed for the anti-Receptor Binding Domain (RBD) titers by ELISA and for the capacity to neutralize the pseudovirus of the Wuhan-Hu-1 strain by luciferase assays; (3) Results; Neither the antibody titers nor the neutralization capacity was significantly different between the three groups. However, the correlation between the antibody titers and the percentage of viral neutralization derived from sera of unvaccinated survivors was higher than that from vaccinated persons with pre-infection (Spearman correlation coefficient (r) = -0.8558; 95% CI, -0.9259 to -0.7288), p <0.0001 vs -0. 581; 95% CI, -0.7679 to -0.3028; p = 0.0002, respectively), indicating the capacity to neutralize the virus is better among the unvaccinated individuals. (4) Conclusions: Vaccines induced anti-RBD titers as high as the natural infection with lower neutralization capacity, and it did not boost the immunity in pre-infected persons.
StartXFit – Nine Months of CrossFit® Intervention Enhance Cardiorespiratory Fitness and Well-Being in CrossFit Beginners
Authors: Schlie Jennifer , Brandt Tom , Schmidt Annette
Published: August 2023

Insufficient physical activity (PA) is associated with low cardiorespiratory fitness, which favors cardiovascular and other non-communicable diseases. Besides, it evidentially affects mental health. Considering the WHO PA guidelines, CrossFit® represents a versatile exercise program, combining aerobic and resistance training with mobility and could help lowering disease incidences among sedentary people. Yet, long-term CrossFit research is sparse. We conducted a nine-months intervention (≥ 2 CrossFit workouts/week) in sixteen beginners (14 males, 35  6.8 years, 180  8.6 cm, 85. 5  19.1 kg). As primary endpoint, VO2max was assessed at baseline, after four, and nine months. A repeated-measures ANOVA and pearson correlation were conducted. Well-being was investigated by WHO-5-index pre- and post-intervention. For exploratory purpose, body composition was tracked. Main outcome was an 11.5 % VO2max improvement with large effect (p < .01, η_p^2 = .27). Strong negative correlations between baseline VO2max and its progression after nine months (p = .006, r = -.654) were found. Well-being increased by 8.7 % (p = .024, d = .51). Body composition improved without statistical significance. Resting metabolic rate increased by 2.2 % (p = .042). This study reveals the potential of CrossFit to enhance physiological and psychological health in beginners. For more robust results, bigger sample sizes with higher proportion of women are needed.
Effects of COVID-19 Outbreak on Korean Adolescents: Impact of Altered Socio-Economic Perception on Physical Activity, Sedentary Behavior, and Stress Levels in an Age-, Gender-, and BMI-matched Study
Authors: Kim Jisu , Hwang In-Whi , Park Jeong-Hui , Kim Youngdeok , Lee Jung-Min
Published: August 2023

The current study is to examine the disparities in physical activity (PA), sedentary behavior (SB), and stress levels in Korean adolescents concerning changes in their perception of family socio-economic status (SES) during COVID-19. Among a total of 6144 Korean adolescents aged 12 to 18, the participants were categorized into two groups based on their responses regarding changes in their family SES during COVID-19: Lower SES (n = 3072) and Non-changed SES (n = 3072), with matching in terms of age, gender, and BMI. All variables were assessed using the 16th year (2020) of the Korean Youth Risk Behavior Survey. Statistical analyses were conducted using SPSS 26.0 version, employing independent t-tests to examine anthropometrics’ differences and multinominal logistic regression to predict the impact of perception of family SES on PA, SB, and stress while comparing the two groups. The significance level was set at α = 0.05. Adolescents in the Lower SES group were less likely to engage in vigorous-intensity PA (VPA) and muscular strength activities compared to those in the Non-changed SES group (p < 0.001) and were 2.3 times more likely to experience a very-severe stress level than the Non-changed SES group (p < 0.001). These results shed light on the importance of promoting VPA and muscular strength activities in adolescents for their physical and mental well-being, particularly during potential future pandemics. Understanding the impact of perceived SES changes on health behaviors can inform targeted interventions and support strategies to improve the health outcomes of adolescents during challenging times.
The Effect of Foliar Salicylic Acid and Zinc Treatments on Proline, Carotenoid, Chlorophyll Content and Anti-oxidant Enzyme Activity in Galanthus elwesii Hook
Authors: Kırgeç Yasemin , Batı ay Ebru , Açıkgöz Muhammed akif
Published: August 2023

Galanthus elwesii Hook is an important plant species of the Amaryllidaceae family and is used for medicinal purposes with its valuable bioactive compounds. The present study was conducted to investigate the effects of foliar salicylic acid (SA) and zinc (Zn) treatments on proline, carotenoid, chlorophyll content and anti-oxidant enzyme activity in G. elwesii. The ascorbate peroxidase (APX), catalase (CAT) enzyme activity, and protein contents were determined with ascorbate oxidation, hydrogen peroxide (H2O2), and Bradford experiments, respectively. The plants were treated with three different concentrations of SA (0.5, 1, and 2 mM) and, and Zn (40, 80, and 120 mM) were compared with the control. Fresh leaves were harvested in the study. APX (3.99 ± 0.58 EU/mg protein) and CAT (154.64 ± 4.10 EU/mg protein) were obtained from Zn 80 and 120 mM treatments at the highest level, respectively. Proline, chlorophyll b, and carotenoid content increased 12.4, 1.54 and 3.95-fold, respectively, in 0.5 mM SA treatments when matched with control group. It was found that increasing doses of SA and Zn increased the content of malondialdehyde (MDA), but this was not at a significant level. The total chlorophyll content increased 2.27-fold in Zn 120 mM + SA 2 mM treatment and the chlorophyll content increased 2.41-fold in Zn 40 mM + SA 1 mM treatment.
ConF: A deep learning model based on BiLSTM, CNN, and cross multi-head attention mechanism for Non-coding RNA Families Prediction
Authors: TERAGAWA SHORYU , Wang Lei
Published: August 2023

This paper presents ConF, a novel deep learning model designed for accurate and efficient prediction of non-coding RNA families. NcRNAs are essential functional RNA molecules involved in various cellular processes, including replication, transcription, and gene expression. Identifying ncRNA families is crucial for comprehensive RNA research, as ncRNAs within the same family often exhibit similar functionalities. Traditional experimental methods for identifying ncRNA fam-ilies are time-consuming and labor-intensive. Computational approaches relying on annotated secondary structure data face limitations in handling complex structures like pseudoknots and have restricted applicability, resulting in suboptimal prediction performance. To overcome these chal-lenges, ConF integrates mainstream techniques such as residual networks with dilated convolutions and cross multi-head attention mechanisms. By employing a combination of dual-layer convolu-tional networks and BiLSTM, ConF effectively captures intricate features embedded within RNA sequences. This feature extraction process leads to significantly improved prediction accuracy compared to existing methods. Experimental evaluations conducted on a ten-fold publicly available dataset demonstrate the superiority of ConF in terms of accuracy, sensitivity, and other perfor-mance metrics. Overall, ConF represents a promising solution for accurate and efficient ncRNA family prediction, addressing the limitations of traditional experimental and computational methods.
Circulatory miRNAs as Correlates of Elevated Pancreatic Fat in a Mixed Ethnic Female Cohort from the TOFI_Asia Study
Authors: Ramzan Farha , Sequeira-Bisson Ivana , Lu Louise W , Mitchell Cameron J , D'Souza Randall , Vickers Mark H , Poppitt Sally , Cameron-Smith David
Published: August 2023

Aim: Ectopic lipid accumulation, including pancreatic steatosis, exacerbates type 2 diabetes risk in susceptible individuals. Dysregulated circulating microRNAs (miRNAs) have been identified to correlate with clinical measures of pancreatitis, pancreatic cancer, and type 1 diabetes. The aim of the current study was, therefore, to examine the association between circulating abundances of candidate miRNAs and pancreatic and liver fat deposition as quantified using magnetic resonance imaging (MRI) and spectroscopy (MRS).
Methods: Asian Chinese (n=34; BMI=26.7±4.2 kg/m2) and European Caucasian (n=34; BMI=28.0±4.5 kg/m2) females from the TOFI_Asia cohort underwent MRI and MRS analysis of pancreas (MR-%pancreas) and liver (MR-%liver fat) respectively to quantify ectopic lipid deposition. Plasma miRNA abundances of a subset of circulatory miRNAs associated with pancreatic and liver steatosis were quantified by qRT-PCR.
Results: miR-21-3p and miR-320a-5p correlated with MR-%pancreas fat, plasma insulin and HOMA2-IR but not MR-%liver fat. MR-%pancreas fat remained associated with decreasing miR-21-3p abundance following multivariate regression analysis.
Conclusions: miR-21-3p and miR-320a were demonstrated to be negatively correlated with MR-%pancreas fat, independent of ethnicity. For miR-21-3p, this relationship persists with the inclusion of MR-%liver fat in the model, suggesting the potential for wider application as a specific circulatory correlate of pancreatic steatosis.
Minimal Mechanisms Responsible for the Dispersive Behaviour of the Madden Julian Oscillation
Authors: Mathew Vincent , Mamidi Kartheek
Published: August 2023

An attempt has been made to explore the relative contributions of moisture feedback processes on tropical intraseasonal oscillation or Madden Julian Oscillation (MJO). We focused on moisture feedback processes, including evaporation wind feedback (EWF) and moisture convergence feedback (MCF), which integrates the mechanisms of convective interactions in the tropical atmosphere. The dynamical framework considered here is a moisture-coupled, single-layer linear shallow-water model on an equatorial beta-plane with zonal momentum damping. With this simple approach, we aimed to recognize the minimal physical mechanisms responsible for the existence of the essential dispersive characteristics of the MJO, including its eastward propagation(k>0), the planetary-scale (small zonal wavenumbers) instability, and the slow phase speed of about ≈ 5 m/sec. Further, we extended our study to determine each feedback mechanism’s influence on the simulated eastward dispersive mode. Our model emphasized that the MJO-like eastward mode is a possible outcome of the combined effect of moisture feedback processes without requiring additional complex mechanisms such as cloud radiative feedback and boundary layer dynamics. The results substantiate the importance of EWF as an energy source for developing eastward moisture mode with a planter-scale instability. Moreover, our model endorses that the MCF alone could not produce instability without surface fluxes, although it has a significant role in developing deep convection. It is found that the MCF exhibits a damping mechanism by regulating the frequency and growth rate of the eastward moisture mode at shorter wavelengths.
Multicentric Study from Southern Italy Hospitals on Oncological Outcomes and Prognostic Factors of Open Partial Horizontal Laryngectomies (OPHL) for Laryngeal Cancer
Authors: Allegra Eugenia , Bianco Maria Rita , Modica Domenico Michele , Azzolina Alfio , Privitera Elio , Latella Daniele , Occhiuzzi Federico , Galfano Mario , Saita Vincenzo
Published: August 2023

In recent years, the number of open preservation surgeries for treatment of laryngeal Cancer has increased. The purpose of this surgery is to avoid the highly mutilating intervention of a total laryngectomy (TL) and to maintain laryngeal function while ensuring oncological radicality. The aim of this study was to assess the oncologic results of OPHL I and II and to identify prognostic factors that could impact patient survival and local failure rates. This study was conducted on 182 patients with laryngeal squamous cell carcinoma treated with OPHLs between 2005 and 2015. The survival rates of a group of patients treated with TL between 2004 and 2014 were taken into con-sideration to compare survival outcomes. The DSS in pT2 and pT3 tumors in relation to the type of surgery showed no statistically significant difference between OPHLs and TL (p=0.54 and p=0.63 respectively). The 5-years T-recurrence free survival showed that pT4 tumors, perineural/vascular positive invasion and OPHL IIb + ARY treated tumors were associated with a higher risk of tumor recurrence (p<0.0001, p=0.0005 and p=0.016 respectively). OPHLs represent an excellent alterna-tive to TL considering the characteristics of the tumor and the general conditions of the patient.
Multi-Scale Recursive Identification of Urban Functional Areas Based on Multi-Source Data
Authors: Liu Ting , Cheng Gang , Yang Jie
Published: August 2023

In recent years, the emergence of spatiotemporal big data has made the transition of functional identification from the physical dimension to socioeconomic or human activities becoming more common. In the identification of urban functional areas, most studies considered only a single data source and a single division scale, the research results have problems such as low update frequency or incomplete information in a single data set, and overfitting or underfitting in a single spatial resolution. Using taxi trajectory data and point of interest (POI) data as the main data source, this study proposes a multi-scale recursive identification method for urban functional areas based on cross-validation. First, used the dynamic time warping (DTW) algorithm generates a time series similarity matrix, the CA-RFM model combines the clustering algorithm and random forest model is constructed, the model uses a clustering algorithm (K-MEDOIDS) to extract sig-nificant feature regions as input, which are imported into the random forest model for UFZ identification. Then, to overcome the shortcomings of single scale in expressing urban structural characteristics, a recursive model of different levels of urban road networks is established to classify multi-scale functional areas. Finally, cross-validation using the CA-RFM model and POI quantitative identification method, obtains the final identification results of urban functional areas. This paper selects Shenzhen as the study area for the case study, the results show that the com-bination of clustering algorithm and random forest model greatly reduces the error of manual selection of training samples. In addition, the research shows the superiority of the multi-scale recursive identification method that fuses multi-source data and performs cross-validation from two aspects, that is, the division speed of urban functional area identification results is accelerated and the accuracy is improved.