bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of Break Event Point Analysis and Margin of Safety in Profit Planning
Authors: Naning Fatmawatie
Published: May 2022

The break event point is a certain amount of production that the company must achieve to reach the break-even point (no profit and / no loss). Margin of safety is the amount of production required so that the company does not suffer losses. The determination of the margin of safety is closely related to the break event point, where the margin of safety is at one level above the break event point in terms of determining the minimum sales required. Both of these are some of the instruments that can be used to plan profits. The purpose of this study was to determine the application of break event point analysis at PT. Beton Jaya Manunggal, knowing the application of margin of safety analysis and to determine profit planning at PT. Jaya Manunggal Concrete. This study uses a non-statistical quantitative approach. The data used in this study is secondary data through PT. Manunggal Jaya Concrete in 2014-2018. The analysis method uses the least square method to plan the net profit of PT. Beton Jaya Manunggal in 2019 with reference to the net sales plan. The result of this research is the break event point of PT. Beton Jaya Manunggal in 2014 – 2018 showed a positive trend with the break event point being above the current year's production during 2015 – 2016. Margin of safety PT. Beton Jaya Manunggal in 2014 – 2018 showed an upward trend with negative margins throughout 2015 – 2016. Profit planning using least squares with reference to net sales planning is quite accurate considering that there is only a difference of 2% above net sales recorded in the 2019 financial statements. Net profit PT. Beton Jaya Manunggal was recorded in 2019 at 1.3 billion Rupiah so that profit planning was not carried out based on the consideration that the recorded profit was less or showed a downward trend when compared to the net profit trend in 2014 – 2018.
CÁC THÀNH TỰU SƯU KHẢO TRUYỆN NGỤ NGÔN VIỆT NAM
Authors: Trang Đặng Thị Thu , Nghĩa Nguyễn Hữu
Published: May 2022

Truyện ngụ ngôn là thể loại văn học dân gian hay, độc đáo, có nhiều ý nghĩa trong cuộc sống, thu hút sự quan tâm của nhiều nhà sưu tầm, nghiên cứu. Áp dụng phương pháp lịch sử cùng với các thao tác so sánh, phân tích, bài viết xác lập cái nhìn tổng quát về quá trình sưu tầm, biên soạn, khảo cứu truyện ngụ ngôn Việt Nam; nhấn mạnh đến những đóng góp, chỉ ra những vấn đề cần tiếp tục khai thác ở các công trình; thông qua đó, hiểu được bước phát triển trong việc sưu tầm, biên soạn, nghiên cứu truyện ngụ ngôn. Từ những cơ sở trên, bài viết góp phần khẳng định thành quả mà folklore học Việt Nam đã đạt được và nêu những vấn đề cần tiếp tục sưu tầm, nghiên cứu thể loại này ở Việt Nam. .
NHẬN THỨC VỀ Y ĐỨC CỦA SINH VIÊN NGÀNH Y TRÊN ĐỊA BÀN THÀNH PHỐ CẦN THƠ
Authors: Nhân Lê Chí , Bảo Võ Thái , Thoại Bùi Huy
Published: May 2022

Bài viết này dựa trên kết quả nghiên cứu của đề tài khảo sát nhận thức về y đức của sinh viên (SV) ngành Y trên địa bàn thành phố Cần Thơ (TPCT). Đối tượng nghiên cứu là nhận thức về y đức của SV thuộc các trường cao đẳng, đại học có đào tạo các ngành Y tế tại Cần Thơ. Kết quả nghiên cứu cho thấy SV ngành Y trên địa bàn TPCT có sự nhận thức rất đa dạng về y đức. Bên cạnh những nhận thức đúng đắn thì vẫn còn không ít SV chưa nhận thức đúng về y đức. Trên cơ sở đó, bài viết đề xuất sáu giải pháp mang tính gợi mở cho các bên liên quan trong công tác hoạch định chính sách cũng như triển khai thực hiện nhằm góp phần nâng cao nhận thức về y đức của SV ngành Y trên địa bàn TPCT trong thời gian tới.
QUÁ TRÌNH ĐÔ THỊ HÓA Ở SÀI GÒN – CHỢ LỚN CUỐI THẾ KỶ XIX ĐẦU THẾ KỶ XX
Authors: Tâm Nguyễn Thị Thanh
Published: May 2022

Sài Gòn – Chợ Lớn trở thành thị tứ phát triển dưới thời Nguyễn với sự giao lưu buôn bán trong và ngoài nước nhưng đô thị này chưa hoàn chỉnh và đồng bộ. Khi Pháp tiến hành chiến tranh xâm lược, chiếm Nam Kỳ lục tỉnh với mưu đồ thôn tính toàn nước Việt Nam và bành trướng thế lực ở khu vực Viễn Đông nên Pháp tiến hành dự án xây dựng đô thị và phát triển hạ tầng cơ sở để chuyển Sài Gòn – Chợ Lớn thành trung tâm đô thị của Nam Kỳ với phương thức sản xuất tư bản chủ nghĩa. Bằng các phương pháp nghiên cứu lịch sử –logic và phân tích, khảo cứu tư liệu, bài viết trình bày cơ bản những nhân tố tác động đến quá trình đô thị hóa Sài Gòn – Chợ Lớn làm thay đổi diện mạo kinh tế, xã hội của Nam Kỳ vào cuối thế kỉ XIX đầu thế kỉ XX.
NGHỆ THUẬT KIẾN TẠO TÌNH HUỐNG TỰ SỰ TRONG TRUYỆN NGẮN VÀ TIỂU THUYẾT CỦA UÔNG TRIỀU
Authors: Phương Mai Hoàng
Published: May 2022

Bài viết tìm hiểu các kiểu tình huống tự sự trong truyện ngắn và tiểu thuyết của Uông Triều: đấng bề trên toàn tri, kẻ dị thuật thấu cảm, người đồng thuật giãi bày. Các kiểu tình huống này được sử dụng tương đối đồng đều; điều đó cho thấy sự đa dạng trong những thể nghiệm tự sự của tác giả. Sự đa dạng đó phù hợp với nội dung tự sự và dụng ý nghệ thuật, đồng thời thống nhất trong một lối viết là đào sâu vào cái tôi nội cảm và khám phá bản thể của con người trong lịch sử cũng như đời sống đương đại. Từ đó, có thể thấy Uông Triều là một trong những ứng cử viên sáng giá cho sự nghiệp “tạo đỉnh” của văn học Việt Nam về sau.
Psycho-social factors as a Correlate of Marital Satisfaction among Couples in northwest Senatorial District of Benue State, Nigeria
Authors: David Ishor Gaver , Samuel Iorkosu Tyover , Onyegbulem Emeka Valentine
Published: May 2022

Marriage as a process of raising a family is an important institution in every society. As such, it has been assumed that a successful marriage is associated with both physiological and psychological health. However, these factors that correlate with marital satisfaction remain unclear and given little attention. The study, therefore, focuses on psychosocial factors as a correlate of marital satisfaction among Couples in the North West Senatorial District of Benue State, Nigeria. the social exchange theory was used to explain the factors that influence marital satisfaction among the couple in the area. To field carry out the study, the researchers adopted the survey research design. The target population of the study includes all the married couples in the North West Senatorial district of Benue State, Nigeria. The sample size of the study was 385 couples. The research instrument was a questionnaire. The data were collected using a questionnaire, and key informants' interviews. The mean and standard deviation of the main variables were calculated and presented with the use of SPSS. The Pearson correlation moment was used to test the correlation between independent variables and the dependent variable. The study revealed among others that psychological factors such as self-esteem, intimacy, and affection were correlated with marital satisfaction. The study also revealed that social factors such as communication, presence of child or children, sexual satisfaction, and closeness have a positive correlation on marital satisfaction among couples in the area. The study suggests among others that the governmental and non-government agencies should carry out more campaigns, workshops, symposiums, conferences to sensitised couples on the right attitudes for a satisfactory marriage for peaceful co-existence in the area.
Self-Identity of Biracial Children: What Role Do Parents Play?
Authors: Ingram Patreese D. , Chaudhary Anil Kumar
Published: May 2022

One of the fastest growing student groups today is the biracial student population. This study is part of a larger exploratory descriptive study on biracial college students with a focus on the extent to which parents socialized their biracial children in the cultures of both parents while growing up and how these students chose to self-identify. Biracial students at a large, predominantly white, research university in the northeastern United States completed an online survey. Descriptive statistics and content analysis were used to analyze the data. The results indicated that most students had adopted a “border” identity. The majority of parents had encouraged their children to have an acceptance and pride in their biracial status. However, many students would have appreciated more exposure and knowledge of their heritages, as well as preparation for dealing with their environment as a biracial person. Students offered recommendations for parental practices to strengthen their racial identity.
A Picture is Worth a Thousand Words: Consumer Perceptions of Agricultural Images
Authors: Rumble Joy N. , Chiarelli Christy , Culbertson Avery , Irani Tracy A.
Published: May 2022

Individuals interpret agricultural images differently according to the direct or cultural meanings they associate with the image, as well as the perspective through which they view the image. In addition, perceptions of agricultural images are commonly influenced by stereotypes. As agricultural communicators, it is important to understand the perceptions consumers have about agricultural images. Understanding these perceptions can allow communicators to use images in their communication that will promote favorable perceptions of the industry. To better understand consumers’ perceptions of agricultural images, this study asked consumers about their perceptions using focus group methodology. Four focus groups were completed with a total of 36 participants. The results indicated that elements of semiotics and perception theory were evident in the participants’ discussion. Thus, these theories combined with the results provide valuable information in regard to selecting images for communication that will create favorable responses among consumers.
The role of procalcitonin as a biomarker for acute pulmonary exacerbation in subjects with cystic fibrosis and non-cystic fibrosis bronchiectasis
Authors: MAMMADOV Firuz , OLGUN YILDIZELI Sehnaz , KOCAKAYA Derya , ARIKAN Huseyin , ÇINAR Caner , ERYUKSEL Emel , CEYHAN Berrin
Published: May 2022

Objective: Patients with cystic fibrosis (CF) and non-CF bronchiectasis are prone to exacerbations of pulmonary infections. C-reactive
protein (CRP) and procalcitonin (PCT) are inflammatory markers. The aim of this study is to evaluate the role of CRP and PCT on
exacerbations of CF and non-CF bronchiectasis.
Patients and Methods: The medical records of 18 CF (52 hospitalizations) and 20 non-CF bronchiectasis patients (51 hospitalizations)
were reviewed retrospectively. CRP, PCT levels and, white blood cell (WBC) counts on admission and follow-up were evaluated.
Results: C-reactive protein levels correlated with PCT levels on admission in all patients. Baseline PCT levels were markedly higher
(>0.5µg/L) in 12% of CF and 10% of non-CF bronchiectasis patients, however, baseline CRP values were markedly higher (>5mg/L)
in 96% of CF and non-CF bronchiectasis patients (p=0.760 and p=0.100, respectively). Baseline CRP and PCT levels were positively
correlated with hospitalization length (r=0.501, p=0.001 and r=0.289, p=0.04, respectively) in CF patients, but not in non-CF
bronchiectasis.
Conclusion: Our study shows the potential utility of these biomarkers to determine the severity of the exacerbation particularly
predicting hospitalization length in CF patients. Both biomarkers could be able to guide antibiotic treatment of infective exacerbations
in CF and non-CF bronchiectasis patients
Green Chemistry: A study on acid-base indicator property of various flower pigments
Authors:   Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy, Venkatramapuram, Tirupathi, India, D Lavanya , shekhar G Guna , A Purushothom , A Pallavi , A. Mohiuddin Omair , Mohiuddin A.
Published: May 2022

Green Chemistry is considered as a significant tool to mitigate the use of hazardous chemicals. It encourages innovation and promotes the creation of products that are environmentally and economically sustainable. Synthetic chemicals which are used as internal indicators in acid- base titrations being hazardous can be substituted by using the natural indicators which gives results with the same accuracy. The accuracy of the observed results has been examined by performing titration between different acids and bases. Results supported this by less variation in the mean value and titre value from that of synthetic indicators. Thus, the use of natural indicators in the acid base titrations is statistically proved. The natural indicator prepared from flower petals is neither harmful to the environment nor it causes any health hazard. Therefore, in this work the use of natural indicator like petal extract is concluded more economical, simple, harmless, pollution free and inert.
Association of Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers with Coronavirus Disease 2019 Severity and Mortality
Authors:   Department of Endocrinology and Nutrition, Infanta Sofía University Hospital, San Sebastián de los Reyes, Spain   Faculty of Medicine, European University of Madrid, Madrid, Spain, Díaz-Guardiola Patricia , Martín-Borge Virginia , García-Fernández Cristina , Teresa Ramírez-Prieto María , Irma Ramírez-Belmar Marcela , García-Romero Gema , de la Calle Esther , Antonio Balsa José
Published: May 2022

Background: A potential association between use of angiotensin-converting–enzyme inhibitors (ACEI) or angiotensin-receptor blockers (ARB) and coronavirus disease 2019 (COVID-19) severity has been suggested. We conducted a retrospective study to investigate the association between ACEI/ARB use and COVID-19 severity and mortality. Methods: The first 1,000 consecutive patients with COVID-19 who were attended in the emergency department at the Infanta Sofía University Hospital were included. Clinical data was manually extracted by reviewing medical records, and the ACEI/ARB prescription was assessed from an electronic pharmacy database. The primary endpoints were critical COVID-19 and mortality. Results: A total of 241 (24.1%) patients had a critical COVID-19 and 171 (17.1%) died. ACEI use was associated with critical COVID-19 (OR 1.90, 95% CI 1.34-2.70), and with mortality (OR 1.98, 95% CI 1.35-2.91) in the unadjusted analysis, but not after adjusting by age, sex and comorbidities (OR 1.15 95% CI 0.69-1.94, and OR 1.00 95% CI 0.56-1.77, respectively). Similarly, ARB use was associated with critical COVID-19 (OR 1.58, 95% CI 1.11-2.58), although not with mortality (OR 1.47, 95% CI 0.98-2.19) in the unadjusted analysis, but not after adjusting by age, sex and comorbidities (OR 0.97, 95% CI 0.57-1.65, and OR 0.74, 95% CI 0.41-1.33, respectively). Conclusion: These results suggest that the use of ACEI/ARB is not independently associated with COVID-19 severity and mortality.
Factors Predicting Treatment Outcome in Hospitalized Patients with Acute Exacerbation of COPD (AECOPD)
Authors:   Department of Pulmonary Medicine, D. Y. Patil Medical College, Nerul, Navi Mumbai, India, Uppe Abhay , Ankale Padmaraj , Sharma Arti , Shah Ria , Nair Girija
Published: May 2022

Objective: The aim of our study was to study the COPD phenotypes, comorbidities and factors predicting treatment outcomes in patients with acute exacerbations of COPD admitted in hospital. Methodology: A retrospective study of fifty patients with acute exacerbation of COPD admitted in a tertiary care hospital during July 2015 to August 2016 was done. Results: It was observed that the mean duration of hospital stay was 8 ± 7 days with 44% of the patient discharged in less than 7 days (short stay) and 56% of patients in more than 7 days (long stay). The factors favouring longer stay in hospital include history of current smoking, hypoxia and CO2 retention while patients on active COPD treatment and cessation of smoking leads to shorter hospital stay. Conclusion: For patients with acute exacerbations of COPD requiring hospitalization, history of current smoking with hypoxia and CO2 retention are associated with longer stay in hospital while patients on active COPD treatment and cessation of smoking leads to shorter hospital stay.
Lithium Poisoning Update in Diagnosis and Treatment
Authors: Rico-Fontalvo Jorge , Daza-Arnedo Rodrigo , Leal-Martínez Victor , Abuabara-Franco Emilio , Pájaro-Galvis Nehomar , Correa-Guerrero José , Raad-Sarabia Maria , Pomares-Lara Alonso , Ayola-Rosales Dayana , Mercado-Anillo Karen , Sepúlveda-Hernandez Yamile , Sepúlveda-Hernandez Huber , Meiyan Sun Meiyan
Published: May 2022

Introduction: Lithium has been used over time in the treatment of psychiatric pathologies, mainly the bipolar spectrum, however, the narrow therapeutic range generates a high incidence of poisoning by this metal, with a very heterogeneous clinical presentation of toxicity which will depend on two factors: the time of evolution, if it is acute or chronic, and the serum levels, ranging from gastrointestinal symptoms to severe neurological compromise. As of today, there is no specific antidote for lithium, so intermittent hemodialysis is the strategy of choice for the intoxicated patient. Objectives: To describe the available and relevant literature on the management of Lithium poisoning. Methodology: A search was performed with the MeSH terms "Lithium, Renal Dialysis, Poisoning, Toxicity, Acute kidney injury" in the ClinicalKey, PubMed and Ovid databases search engines, finding 156 results, of which 47 were used to develop this manuscript. Conclusions: Lithium poisoning is frequent due to its narrow therapeutic margin, so serum lithium levels should be monitored in patients medicated with it. Today there is no specific antidote, so renal replacement therapy is the best therapeutic option for lithium poisoning, demonstrating high efficiency, especially in cases of marked neurotoxicity. It is necessary to assess the need to initiate timely management in order to achieve a rapid clearance of the drug and decrease the rate of complications and mortality.
The Obstinate Refractory and Resistance Hypertension
Authors:   JLN Medical College, Aryabhatta University, Bhagalpur, Bihar, India, Kamal Choudhry Raj , Kumar Singh Amrendra
Published: May 2022

Resistant hypertension (RHTN) is relatively common with an estimated prevalence of 10-20% of treated hypertensive patients. It is defined as blood pressure (BP) >140/90 mmHg treated with ≥3 antihypertensive medications, including a diuretic, if tolerated. Refractory hypertension is a novel phenotype of severe antihypertensive treatment failure. The proposed definition for refractory hypertension, i.e. BP >140/90 mmHg with use of ≥5 different antihypertensive medications, including a diuretic and a mineralocorticoid receptor antagonist (MRA) has been applied inconsistently. In comparison to RHTN, refractory hypertension seems to be less prevalent than RHTN. This review focuses on current knowledge about this novel phenotype compared with RHTN including definition, prevalence, mechanisms, characteristics and comorbidities, including cardiovascular risk. In patients with RHTN excess fluid retention is thought to be a common mechanism for the development of RHTN. Recently, evidence has emerged suggesting that refractory hypertension may be more of neurogenic etiology due to increased sympathetic activity as opposed to excess fluid retention. Treatment recommendations for RHTN are generally based on use and intensification of diuretic therapy, especially with the combination of a long-acting thiazide-like diuretic and an MRA. Based on findings from available studies, such an approach does not seem to be a successful strategy to control BP in patients with refractory hypertension and effective sympathetic inhibition in such patients, either with medications and/or device based approaches may be needed.
The Impact of Alpha-Lipoic Acid on Insulin Resistance and Inflammatory Parameters in Patients with Type 2 Diabetes Mellitus and Cardiac Autonomic Neuropathy
Authors:   Department of Endocrinology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine, Serhiyenko Victoria
Published: May 2022

Development of chronic complications in type 2 diabetes mellitus (T2DM), namely cardiac automonic neuropathy (CAN), had been implicated as an independent risk factor for cardiovascular mortality. This paper presents the results obtained during the study of possible alpha-lipoic acid (ALA) impact on the state of insulin resistance (IR), the content of some pro- and anti-inflammatory factors in patients with T2DM and definite stage of CAN. Our study involved 33 persons with diagnosed T2DM and definite CAN, which were allocated to one of two groups. The control group (15 patients) received standard hypoglycemic treatment, whereas the intervention group (18 patients) received ALA 600 mg in film-coated tablets/q.d. in addition to standard therapy. Treatment period was 3 months in duration. Levels of glycated hemoglobin A1c, glucose, immunoreactive insulin (IRI), leptin, interleukin (IL) IL-6 and IL-8, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha) in the blood were measured. TNF-alpha/IL-10 ratio and Homeostasis model assessment IR (HOMA-IR) were calculated. The significant reduction in glucose, IRI, leptin concentration and HOMA-IR parameters; decrease in the pro-inflammatory link activity, namely hs-CRP, TNF-alpha, IL-6 and IL-8 levels, TNF-alpha/IL-10 ratio, with no changes in IL-10 content after 3 months of treatment was found. The results of our study demonstrated the decrease in the pro-inflammatory link activity after treatment and allow us to consider ALA as one of the promising drug for complex treatment of definite stage of CAN in patients with T2DM.
Acquired Hemophilia B Through Liver Transplantation: A Case Report and Literature Review
Authors:   Cardeza Foundation for Hematologic Research, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia PA, USA, Jane Kurian Christine , Alan Drelich Douglass , Rizk Sanaa
Published: May 2022

Hemophilia B, also called Christmas disease, is an X-linked inherited bleeding disorder that predominantly affects males, and it is caused by deficiency of coagulation factor IX. Factor IX is a coagulation factor produced in the liver. Liver transplantation from hemophilia B donors is neither widely documented nor performed due to presumed risk of developing increased bleeding tendency in the recipient due to potential acquired factor IX deficiency. In this review, we present a case of liver and kidney transplantation from a donor with mild hemophilia B to a recipient with no history of hemophilia B and literature review. This is a relatively rare situation with only two other prior case reports of acquired Hemophilia B through liver transplantation noted in 2015. The 2 cases presented in the literature lead to acquired hemophilia B in liver transplant recipients since donors were not screened due to mild disease and low suspicion level. In our case, the donor was known to have mild Hemophilia B and the recipient had a rapid decline – thus it is imperative to weigh risks and benefits of transplantation from this donor population. While those individuals with mild hemophilia B disease (and low bleeding burden) should be considered as an alternative donor for liver transplantation, appropriate counseling should be done with the recipient about possible bleeding risks and OLT should only occur after patient consent. A multidisciplinary approach should involve hematology in case factor replacement therapy is needed post transplantation and for long term follow up.
Average Real Variability of Diastolic Blood Pressure During Acute Phase Could Independently Predict 3-month Functional Outcome for Ischemic Stroke
Authors:   Department of Neurology, The First Affiliated Hospital of Jinan University, Guangzhou, China, Liu Wenzhu , Chen Yanping , Wu Xiafeng , Tan Zefeng
Published: May 2022

Background and purpose-Blood pressure variability has a significant effect on stroke. There were controversial reports about its relationship with short term functional outcome remains controversial for ischemic stroke or transient ischemic attack (TIA). There were limited studies about its long-term effect. Our aim was to elucidate the effect of BPV on a 3-month functional outcome in patients with acute ischemic stroke or TIA. Methods—In this prospective observational study, a consecutive series of 400 patients were enrolled with acute ischemic stroke or TIA within 7 days. All patients were referred and monitored for BP at 2-hour intervals in the first 24 hours. Afterward, the BP was recorded every four hours up to the 7th day, with 1-hour deviation the daytime and 2 hours at night. All BP results were recorded into an electronic medical record (EMR) system. Average real variability (ARV) was used to analyze the blood pressure variability (BPV). All patients were followed up as planned for 90 days. The primary outcome was evaluated by the modified Rankin Scale (mRS); an unfavorable outcome was mRS≥2. For comparison, patients were respectively divided into two groups based on systolic blood pressure ARV (SBP ARV) or diastolic blood pressure ARV (DBP ARV). A multivariate logistic regression model was used to estimate the effect of between ARV BPV on functional outcomes. Results-Among the 400 patients, 46 (11.4%) had an unfavorable outcome (mRS>2) at 90 days. Their mean 24h DBP ARV was significantly higher than others (10.42±3.63 vs. 9.83±4.27 mm Hg; p=0.03). The high 24hDBPARV was defined above the median of 7.75 mmHg, which was statistically associated with an unfavorable outcome (64.7% vs. 35.3%; P=0.004). Further stepwise logistic regression analysis indicated that 24h high DBPARV was the independent predictor of an unfavorable outcome (adjusted OR 2.44%, 95% confidence interval: 1.24-4.74, P<0.01). Conclusions—High DBPARV during the acute phase is an independent and significant predictor of 90-day functional outcome for ischemic stroke or TIA.
The Effect of Experimental Periodontitis on the Serum Levels of Leptin and IL-18 in Insulin-Treated Diabetic Rats
Authors:   Department of Periodontology, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece, Pepelassi Eudoxie , Xynogala Ioanna , Perrea Despina , Pantopoulou Alkistis , Agrogiannis George , Vrotsos Ioannis
Published: May 2022

The aim of this study in rats was to assess the effect of ligature-induced periodontitis on insulin-treated type 1 diabetes in terms of serum levels of leptin and interleukin-18 (IL-18). Twenty five male Wistar rats were studied, out of 40 initially used: (1) 14 rats with insulin-treated diabetes (control, DI) and (2) 11 rats with combination of insulin-treated diabetes and periodontitis (test, DIP). For all rats, type 1 diabetes was streptozotocin-induced and insulin treatment started on day 5. For DIP group, periodontitis was induced by ligation on day 16. Serum levels of leptin and IL-18 were assessed on days 16 (baseline) and 77 (final) by using multiplex immunoassay. All rats were sacrificed on day 77 (end of the study). Insulin treatment in the newly-induced diabetes significantly increased serum leptin levels and significantly reduced serum IL-18 levels. In the newly-induced diabetes, the combination of the continuation of insulin treatment and periodontitis non-significantly increased serum leptin and IL-18 levels. Serum IL-18 levels were significantly higher for the combination of periodontitis and insulin-treated diabetes as compared to insulin-treated diabetes alone. Within its limits, this study in rats showed that experimental periodontitis induced changes in serum biomarker levels suggestive of alterations in the systemic inflammation generated by insulin-treated type 1 diabetes.
Continuous 4 Percent Albumin Versus Intermittent 20 Percent Albumin in Adults with Septic Shock: A Prospective, Phase IV, Open-label Randomized Trial
Authors:   BioMaterials and BioEngineering, National Institute of Health and Medical Research, Faculty of Odontology, University of Strasbourg, Strasbourg, France, Schneider Francis , Castelain Vincent , Morel Guillaume , Dureau Anne-Florence , Poidevin Antoine , Ludes Pierre-Olivier , Fabacher Thibaut , Senger Bernard , Meyer Nicolas , Metz-Boutigue Marie-Hélène
Published: May 2022

Whether a specific way of infusing albumin affects outcome in patients with major oxidative stress remains uncertain. To determine whether outcome measurements (survival, organ failure and care-related infections) are different according to different regimens of albumin infusion, we conducted a phase IV, randomized, open-label trial to compare the effects of continuous infusion of 4 percent albumin versus intermittent 20 percent albumin on outcome measurements in three third level-hospital intensive care unit (ICU) patients with septic shock. We randomly assigned 125 consecutive patients with septic shock when serum albumin became <20g/L. Patients received either 4 percent albumin (12.5mL/kg) continuously or 20 percent albumin (100mL over 1h/8h) intermittently (controls) until serum albumin ranged between 25 and 30g/L and norepinephrine could be weaned. The primary outcome measure was death from any cause during the 28-day period after randomization. The other outcome parameters were ICU- and hospital length of stay, serum albumin concentrations, SOFA score and lactate over the 4 days following inclusion, care-related infections and tolerance of albumin over the 28-day period after randomization. Data were analyzed with Bayesian methods. Of the 125 patients who underwent randomization, 63 received 4 percent albumin and 62 received 20 percent albumin; groups had balanced baseline characteristics. There were 19 deaths in the experimental group, as compared with 20 in the control group (Pr=0.40). The proportion of patients with new multiple-organ failure (assessed by daily SOFA) was similar in the groups (RR=0.71 [0.29-1.41], Pr=0.14). There were no differences in the medians [IQR]) numbers of days spent in the ICU (12.0 [7.5; 22.0] versus 13 [8.0; 24.5] days, Pr=0.23), in days spent within hospital (29.0 [10.5; 44.0] versus 24 [14.0; 46.8] days, Pr=0.32). In contrast, there were fewer patients with care-related infection in the study group, (14.3% versus 45.2%, Pr<0.001). Limitations concern lack of double blinding related to different regimens of infusion: this may impact results. To conclude, the continuous supply of 4 percent albumin in septic shock patients with serum albumin <20g/L decreases care-related infection (by two third) but does not result in better survival.
Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy
Authors:   Laboratory of Research and Medical Analysis of the Fraternal of the Royal Gendarmerie, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco, Kahouli Sophia , Zahid Hafid , El kabbaj Saâd , Benkirane Majid , Messaoudi Nezha
Published: May 2022

Introduction: Non-Hodgkin's lymphoblastic B lymphoma with lymph node location is exceptional in children. Unlike acute lymphoblastic leukemia, which is the first cancer in children around the age of 3 with a favorable prognosis with a survival of 5 years in 90%. Observation: child, 15 years old. The hospital admission examination showed a febrile patient (40°C), bilateral cervical and inguinal polyadenopathies, the absence of hepatosplenomegaly. The hemogram at entry found bicytopenia made up of angerogenic anemia and thrombocytopenia. On the haematological level, there has been an evolution towards pancytopenia. A lymph node biopsy showed medullary infiltration with lymphoma cells of phenotype B. The karyotype found hyper diploidy with t (9.22). The patient was put on corticosteroid therapy, hyperhydration and (Allopurinol) followed by COP type chemotherapy (Cyclophosphamide, Oncovin, Prednisone) with good tolerance. A year later the patient presented with a feverish peak (40°C). Only a hematological relapse in the form of acute leukemia. Therapeutically, it was decided to re-induce the patient according to the GRAALL catch-up protocol (Idarubicin-Aracytine) and to propose it for an allograft of bone marrow, but unfortunately the patient died. Conclusion: Lymphoblastic lymphoma / Acute lymphoblastic leukemia B, associated with t (9; 22) and hyperdiploidy in children is an exceptional hemopathy and has a negative diagnosis.
Contribution of Scanner in the Breast Cancer Extension Assessment in the Radiology Department of CNHU-HKM in Benin
Authors:   Department of Radiology and Medical Imaging, National Teaching University Hospital Hubert Koutoukou Maga (CNHU-HKM), Cotonou, Benin, Ahouansou Patricia Yekpe , Sonia Adjadohoun , Symphorose Lokossou , Gabriel Ngamo , Andreas Lokossou , Miralda Kiki , Djivèdé Akanni , Olivier Biaou
Published: May 2022

Objective: Breast cancer is the most common female cancer in the world. The prognosis depends on whether metastasis is present or not. The objective of this study was to provide an overview of the CT scan aspects identified during the evaluation of breast cancer extension in the Radiology department of the Teaching University Hospital of Hubert Koutoukou Maga (CNHU-HKM) in Cotonou in Benin. Materials and methods: It was a descriptive study with retrospective collection, conducted from January 1, 2018 to January 31, 2019 (13 months), in the Radiology department of CNHU-HKM. It focused on patients referred for a chest-abdominal-pelvic computed tomography (PET) scan, as part of an extension assessment for breast cancer. Results: During the period of the study, 40 chest-abdominal-pelvic CT scans were compiled, of which 38 (95%) were women and 02 men (5%), and among which 23 were metastatic, accountings for a prevalence of 57.5%. The average age was 51.22±16.33 with extremes of 30 and 83 years old. Among our patients, 32 (80%) had undergone a CT scan for an initial diagnostic of extension assessment, and 08 (20%) for the therapeutic response assessment. According to the TNM classification, T4 tumors accounted for 27.5% (11 cases). Lymph node involvement was found in 18 cases (43.90%), accounting for 12 (30%) of N1 and 6 (15%) of N3. The most commonly found metastatic sites were the lung in 25% followed by the pleura and the liver with equal percentages (10%). The metastases CT scan aspect was typically a carcinomatous lymphangitis appearance; fluid pleural effusions; hypodenses, hypovascular nodules hepatics; osteolytic or mixed bone damage and peritoneum, especially fluid effusion associated with peritoneal nodules. Conclusion: The frequency of breast cancer metastases is high in Benin. The most commonly found metastatic sites on scanner in descending order are the lungs, liver and bones.
PEMULIHAN PONDOK DAUD: LANDASAN TEOLOGIS DAN PEMBARUAN PUJIAN PENYEMBAHAN PENTAKOSTA MASA KINI
Authors: Destyanto Twin Yoshua R. , Lubianto Dony , Jono  , Tuanakotta Minerva Gabriela
Published: May 2022

Pentecostal praise and worship always develop time by time. The pattern changes can be understood as a continuous process of church restoration from time to time towards the apostolic church. The restoration of Tabernacle of David (RTOD) is proposed to be a reference for Pentecostals to formulate the theological foundation in renewing the pattern of praise and worship in the present era. This paper aims to (i) explain the theological basis of the Pentecostal pattern of praise and worship in today's era, (ii) explain the theological meaning of RTOD prophecy and its relationship to praise and worship, and (iii) explain the application of RTOD in renewal of the Pentecostal praise and worship in the present era. This paper uses a qualitative method by applying a systematic literature study and phenomenological approaches to understand the theological basis of praise and worship pattern, the meaning of RTOD in general and related to praise and worship, components in RTOD, and its application in praise worship. The results of the study show that the RTOD can be used as a theological foundation and renewal of Pentecostal praise and worship in the present era.So, it can be concluded that the theological basis and definition RTOD can be used as a reference for applying it in the praise and worship of today's Pentecostals.
New Hope in Microbial Multidrug Resistance
Authors: Ahire Eknath D. , Kshirsagar Sanjay J.
Published: May 2022

From the last some decades, microbial multidrug resistance (MDR) has developed one of the big treats in the many drug therapy. Due to this effect, so many sectors were get affected including the pharmaceutical sector, animal husbandry sector as well as in some way the agriculture sector too. There are so many mechanisms were developed by the microbes to developed resistance towards the medicines consisting of the development of degrading enzymes, structural modification in the microbes which is responsible to bind the drug, as well as last but not the least developing many effluxes pumps to push drug molecules outside of the microbial cell. Many studies demonstrated that lots of antibiotics and anticancer agents are majorly get affected by efflux pumps present on the cell wall. These mechanisms are observed in many common microbes including gram-positive and gram-negative microbes. As a result, efflux pumps are to be taken on top priority for the minimization of multidrug resistance. Up to date lots of work is done regarding the permeation glycoprotein (P-gp) efflux pump inhibition but still, there is a need to explore some more innovative approaches towards MDR. In this current perspective, we have discussed the key points related to pre-existing and future prospects in this regard.
PLANTAS MEDICINAIS MANIPULAÇÃO E USO NA COMUNIDADE QUILOMBOLA DO CEDRO - MINEIROS-GO
Authors:   IF Goiano, de Araújo Barbosa Kennedy , Guimarães Silva Fabiano , de Souza Luzia Francisca , de Oliveira Menino Gisele Cristina , Silva Santos Tatianne
Published: May 2022

Este livro é parte dos resultados obtidos por meio da pesquisa intitulada “Cultura Quilombola do Cedro em perspectiva intercultural no Ensino Básico”, financiada pelo Conselho Nacional de desenvolvimento Científico e Tecnológico (CNPq), desenvolvida por servidores do Instituto Federal de Educação, Ciência e Tecnologia Goiano (IF Goiano), em parceria com a Universidade Federal de Jataí/GO (UFJ). De 2015 a 2018 foram realizados estudos de caráter etnográfico e etnobotânico na Comunidade Quilombola do Cedro, localizada na cidade de Mineiros, no estado de Goiás, com objetivo de resgatar as histórias culturais locais e a inter-relação homem e planta, fortalecendo a preservação das diversidades cultural e vegetal. Como resultado dessa pesquisa foi elaborada uma coleção de material paradidático que visa contribuir para um diálogo intercultural entre a comunidade dos remanescentes e a sociedade, em especial, com a comunidade escolar. Os saberes tradicionais dos cedrinos sobre as plantas medicinais do bioma Cerrado tem chamado atenção do meio acadêmico. Neste material, encontram-se registradas aproximadamente 170 espécies de plantas utilizadas pelos remanescentes na manipulação de seus produtos. A catalogação traz o nome científico e popular, família e a parte da planta utilizada como princípio ativo. Esta obra está dividida em três partes: a primeira apresenta aspectos históricos, geográficos, socioeconômicos e culturais da Comunidade Quilombola do Cedro; a segunda parte traz um relato sobre o trabalho dos cedrinos com as plantas medicinais e a última apresenta a catalogação de parte das plantas medicinais utilizadas por eles.
MAXIMUM POWER TRACKING OF A SOLAR SYSTEM USING IMPROVED PARTICLE SWARM OPTIMIZATION ALGORITHM
Authors:   Electronics and Communication Engineering Department, Ramgarhia Institute of Engineering & Technology, Phagwara, Punjab, India, Singh Palwinder , Kaur Manpreet ,   Electronics and Communication Engineering Department, Ramgarhia Institute of Engineering & Technology, Phagwara, Punjab, India, Dhillon Dr. Naveen ,   Electronics and Communication Engineering Department, Ramgarhia Institute of Engineering & Technology, Phagwara, Punjab, India
Published: May 2022

For photovoltaic systems to be more efficient, maximum power point (MPP) tracking of the solar arrays is necessary. The output power of solar arrays is influenced by two factors: temperature and solar irradiation. It is also possible that a traditional MPP tracker would operate incorrectly because to the mismatch effect produced by partial shadow. There are many maximum values for the solar array power–current characteristics when it is partly shaded. For PV systems in partly shadowed conditions, this research provides an MPPT approach with enhanced particle swarm optimization algorithm.
Use of facemask during the COVID-19 pandemic in Southeastern Nigeria: an observational study
Authors:   Department of Public Health, Federal University of Technology, Owerri, PMB 1526, Owerri, Imo State, Nigeria, Chukwuocha Uchechukwu Madukaku , Ogboeze Joshua Chisom ,   Department of Public Health, Federal University of Technology, Owerri, PMB 1526, Owerri, Imo State, Nigeria, Bosede Ayoola Oluwaseun ,   Department of Environmental Health Science, Federal University of Technology, Owerri, PMB 1526, Owerri, Imo State, Nigeria, Dozie Ugonma Winnie ,   Department of Public Health, Federal University of Technology, Owerri, PMB 1526, Owerri, Imo State, Nigeria, Ekeleme Uzochukwu Godswill ,   Department of Public Health, Federal University of Technology, Owerri, PMB 1526, Owerri, Imo State, Nigeria, Akam Victoria Ngozi ,   Department of Public Health, Federal University of Technology, Owerri, PMB 1526, Owerri, Imo State, Nigeria, Chukwu Rita Ogechi ,   Department of Public Health, Federal University of Technology, Owerri, PMB 1526, Owerri, Imo State, Nigeria
Published: May 2022

The use of facemask for the control of the spread of the novel corona virus among the population has been recommended by the health authorities. This is as a result of its effectiveness in the control of various infectious respiratory diseases during past epidemics and pandemics. This observational study was carried out to assess the frequency of use, appropriateness of application, type, and the quality of the used facemasks among the residents of southeastern Nigeria during the COVID-19 pandemic and to be able to draw inference from this observation on whether facemask usage can aid in controlling the spread of the disease in the study area and the country at large. Using a two-stage sampling technique, a total of 3100 individuals were observed for the type, quality, appropriateness, and frequency of facemasks usage from both rural and urban settings in the study area. Frequency distribution tables were used to categorize and describe the observed variables, Chi-square (X2) test was used to check the association between categorical variables. Among the observed individuals, 46.4% used facemasks. The most common facemask used was cloth mask (28.6%). About 16.0% of the participants correctly used their facemasks. The highest usage was observed in the urban location (49.2%). More people used facemasks in urban areas (p<0.001), in the bank (p< 0.001), in the morning (p< 0.001) among the males (p< 0.001), and among the adolescents (p< 0.001). The observed rate of facemask usage, however, may not be good enough to protect the population against the spread of COVID-19, therefore adequate sensitization on the need for proper use of facemasks by the public should be prioritized.
KINETICS OF QUATERNIZATION BETWEEN N, N-DIMETHYLANILINE AND BENZYL CHLORIDE IN POLAR SOLVENTS-A REVISIT TO MENSHUTKIN REACTION
Authors: Bashpa P. , Rajendran P. , Bijudas K.
Published: May 2022

This work reports an extension of Menshutkin reaction and involves the studies on kinetics of quaternization reaction between N,N-Dimethylaniline and benzyl chloride in acetone and in other various solvents at 300 K. The progress of the reaction was followed by measuring the conductance of the product formed at regular intervals of time. The effect of [benzyl chloride] and [N,N-Dimethylaniline] on reaction rate was studied under pseudo-first order condition and the rate showed first order dependence on both [benzyl chloride] and [N,N-Dimethylaniline]. The effect of dielectric constant of the medium on reaction rate was studied by employing various solvents such as methyl ethyl ketone, isopropyl alcohol, ethyl alcohol, methyl alcohol and acetonitrile and the rate is found to increase with increase in dielectric constant of the medium. The linear plot with a negative slope on plotting log k2 against 1/D where D is the dielectric constant of the medium indicates the existence of a highly charged or a polar transition state during the progress of the reaction. The quaternization reaction was also carried out at different temperatures so as to compute the various thermodynamic parameters like activation energy, enthalpy of activation, entropy of activation and Gibb’s free energy change. The higher value of activation energy is attributed for a slower reaction which is sterically controlled rather than thermodynamically controlled. The negative value of entropy of activation (ΔS*) indicates some sort of surrendering of disorder in the transition state on its formation which proves that it is highly ordered with sufficient charge separation and polar in character. The product after purification was analysed by melting point and infra-red spectral analysis and is proved to be N-Benzyl-N,N-dimethylphenylmethanaminium chloride. A plausible mechanism in accordance with the obtained experimental results is reported.
BIOCHEMICAL STUDY OF ANTIOXIDANT-OXIDANT INDEX IN ORAL POTENTIALLY MALIGNANT DISORDERS AND ORAL SQUAMOUS CELL CARCINOMA
Authors: Shukla Ranu
Published: May 2022

The aim of present work was to evaluate and compare the salivary levels of nitric oxide, vitamin C, Total Sialic acid and GSH in cases of Oral Potentially Malignant Disorders (OPMDs) and Oral Squamous Cell Carcinoma (OSCC) and healthy controls. The mean nitric oxide level was 27.34±5.51 μmol/l in OSCC group, 22.5±2.33 μmol/l in OPMD group and 10.11±0.88μmol/l in control group. The glutathione reductase activity in control patients was found to be 0.0915 U/ml under optimal pH, temperature and Km. In OPMD group, the GR activity was found to be 0.0515 U/ml. Similarly, the activity in the OSCC group was found to be 0.0292 U/ml. The total sialic acid (TSA) in the saliva of control patients was found to be 41.241±5.3312μg/mL. In the case of OPMD patients, it was 64.25±4.33μg/mL and in the OSCC patients it was, 79.60±6.93 μg/mL., The levels of salivary vitamin C and glutathione were significantly reduced and those of nitric oxide and sialic acid were raised in patients having OPMD’s and oral squamous cell carcinoma. The anti-oxidant to oxidant index (AOI) was measured between NO and vitamin C; NO and GSH; total sialic acid and vitamin C and lastly, total sialic acid and GSH. Thus, the findings of the present study indicate that estimation of Vitamin C, NO, GSH and sialic acid can be suitably used and could assist in the early diagnosis of potentially malignant disorders and oral cancer using saliva.
SIMPLE RP-HPLC METHOD DEVELOPMENT FOR THE ESTIMATION OF ALMOTRIPTAN MALATE IN NASAL IN-SITU FORMULATION
Authors: Parashar Megha , Jain Ashish
Published: May 2022

For the determination of Almotriptan malate in bulk and produced nasal in situ formulation, a new sensitive and quick HPLC technique was developed and validated according to ICH guidelines. The HPLC analysis was carried out using a waters system with a Thermo Scientific C18 (250 cm 4.6 mm) 5 m column and a mobile phase of acetonitrile: 20Mm KH2PO4 in an 80:20 v/v ratio, at a flow rate of 1.0mL/min. The detection was done at a wavelength of 282, and Almotriptan malate had a retention time of 5.658 minutes. The total time spent running was 10.0 minutes. Over the concentration range of 2-10 g/ml, the calibration plot revealed a linear relationship. The LOD and LOQ were 0.12 and 0.35μg, respectively. The accuracy of the proposed method was determined by recovery studies and was found to be near to 100 and % RSD value was found less than 2. The repeatability testing for both standard and sample solutions showed that the method is precise within the acceptable limits. RSD% of the determination of precision was less than 2%. The proposed method showed excellent linearity, accuracy, precision, specificity, LOD, LOQ, and system suitability results within the acceptance criteria. In addition, the main features of the developed method are low run time and retention time around 5 min.