bluuebunny/crossref_metadata_2025 huggingface dataset:
A Qualitative Study of US Women's Perspectives on Confidence for Physiologic Birth in the Birth Center Model of Prenatal Care
Authors: Neerland Carrie E. , Skalisky Arielle E.
Published: March 2022

Introduction

The purpose of this study was to increase understanding of the components of the US birth center model of prenatal care and how the birth center prenatal care model contributes to birthing people's confidence for physiologic childbirth.

Methods

This was a qualitative descriptive study using semistructured interviews with individuals who gave birth in freestanding birth centers. Birthing people were recruited from freestanding birth centers in a Midwestern US state and were between the ages of 18 and 42, were English‐speaking, and had experienced a birth center birth within the previous 6 months. Interviews were transcribed and analyzed using Glaser's constant comparative method.

Results

Twelve women who gave birth in birth centers, representing urban and rural settings, participated. Four core categories were identified encompassing the components of birth center prenatal care and how the birth center model contributes to women's confidence for physiologic birth: birth center culture and processes, midwifery model of care within the birth center, internal influences, and outside influences.

Discussion

Women who gave birth in birth centers believed that the birth center culture and environment, the midwifery model of care in the birth center, internal influences including the belief that birth is a normal physiologic process, and outside influences including family support and positive birth stories contributed to their confidence for physiologic birth.
Effect of gestational weight gain on preeclampsia among underweight women: A single tertiary referral center study in Japanese women
Authors: Kyozuka Hyo , Jin Toki , Fujimori Mimori , Nomura Shinji , Suzuki Daisuke , Fukuda Toma , Murata Tsuyoshi , Yasuda Shun , Yamaguchi Akiko , Nomura Yasuhisa , Fujimori Keiya
Published: March 2022

Aim

To examine the effect of weight gain during pregnancy on preeclampsia among women with a prepregnancy body mass index < 18.5 kg/m2.

Methods

This retrospective cohort study included 479 Japanese women with singleton pregnancies and a prepregnancy body mass index < 18.5 kg/m2, who gave birth between 2013 and 2019 at Ohta Nishinouchi Hospital. The study included 22 (18 with preeclampsia and four with gestational hypertension) and 457 patients with and without hypertensive disorders of pregnancy, respectively.

Results

The prevalence of hypertensive disorders of pregnancy and preeclampsia was 4.6% and 3.8%, respectively. With weight gain during pregnancy (continuous variable) set as a reference, multiple logistic regression revealed that excessive weight gain during pregnancy increased the risk of preeclampsia (adjusted odds ratio: 1.13, 95% confidence interval: 1.00–1.28, p < 0.05) and hypertensive disorders of pregnancy (adjusted odds ratio: 1.15, 95% confidence interval: 1.03–1.29, p < 0.05). Based on receiver operating characteristic curve analyses (area under the curve 0.65, 95% confidence interval: 0.50–0.80; p < 0.05), we determined the cutoff value of weight gain during pregnancy for the occurrence of preeclampsia among women with body mass index < 18.5 kg/m2 to be 13.0 kg, with sensitivity and specificity of 0.50 and 0.78, respectively.

Conclusion

This study indicates that excessive weight gain during pregnancy increases preeclampsia risk among underweight women and provides new recommendations for weight gain during pregnancy for such women. Further research regarding the pathogenesis of preeclampsia for underweight women is warranted.
Risk and Resilience Factors Associated With Frequency of School‐Based Health Center Use
Authors: Soleimanpour Samira , Geierstanger Sara , Lucas Ruby , Ng Sandy , Ferrey Ignacio
Published: March 2022

BACKGROUND

School‐based health centers (SBHCs) provide health care to vulnerable youth. The purpose of the study was to identify characteristics of youth who use SBHCs with the highest frequency to understand their health needs and receipt of health services.

METHODS

This study examined cross‐sectional survey data from adolescents in 3 urban school districts (n = 2641) to identify the characteristics of youth who use SBHCs with high frequency (10+ visits). Analyses included calculations of simple frequencies and percentages, chi‐square tests of significance and multivariate regression.

RESULTS

High‐frequency SBHC users were more likely to have seriously considered attempting suicide (adjusted odds ratio [AOR]: 3.2), be sexually active (AOR: 6.8), and have been victimized at school (AOR: 2.2) compared to their peers who did not use the SBHC. High‐frequency SBHC users were also significantly more likely than their peers to report “always” getting mental health (AOR: 7.0) and sexual health (AOR: 6.6) care when needed, and having talked with a health care provider about their moods/feelings (AOR: 3.1) and how school is going (AOR: 3.2) in the past year.

CONCLUSIONS

These findings hold important relevance to demonstrating the value of SBHCs in increasing vulnerable youth's access to health care, particularly in urban settings.
Morphology, molecular phylogeny and systematics of the diatom genus Fallacia (Sellaphoraceae), with descriptions of three new species1
Authors: Li Yuhang , Suzuki Hidekazu , Nagumo Tamotsu , Tanaka Jiro , Sun Zhongmin , Xu Kuidong
Published: March 2022

Fallacia is distinguished morpho‐anatomically from Navicula sensu lato based on the possession of an H‐shaped chloroplast, lateral sterna and a finely porous conopeum, but whether this genus is monophyletic is still in question. Three new Fallacia species are described based on morphology and SSU rRNA and rbcL gene sequences: Fallacia tateyamensis sp. nov., Fallacia bosoensis sp. nov. and Fallacia laevis sp. nov. We performed the first comprehensive molecular and morphological phylogenetic analyses of 31 Fallacia species based on 11 new sequences from six species and 23 morphological characters. We also documented the detailed morphogenesis of Fallacia for the first time. Fallacia is not monophyletic. Both morphological and DNA sequence data supported the separation of Rossia from Fallacia, while the phylogenetic position of Pseudofallacia is uncertain. We recognized four morphogroups in Fallacia by morphological and molecular phylogenetic analyses. Ancestral character reconstruction indicated that diatoms in Sellaphoraceae evolved from the possession of two lateral narrow parallel depressions covered by narrow nonporous conopea, to lyre‐shaped canals covered by wide porous conopea. Lanceolate canals and the presence of areolae in canals evolved multiple times independently.
Transvenous electrical cardioversion of atrial fibrillation in horses: Horse and procedural factors correlated with success and recurrence
Authors: Vernemmen Ingrid , Van Steenkiste Glenn , Dufourni Alexander , Decloedt Annelies , van Loon Gunther
Published: March 2022

Background

Transvenous electrical cardioversion (TVEC) is 1 of the main treatment options for atrial fibrillation (AF) in horses. Large‐scale studies on factors affecting success and prognosis have primarily been performed in Standardbred populations.

Hypothesis/Objectives

To determine factors affecting cardioversion success, cardioversion difficulty and recurrence in a predominant Warmblood study sample.

Animals

TVEC records of 199 horses.

Methods

Retrospective study of TVEC procedures of horses admitted for AF without severe echocardiographic abnormalities. Horse and procedural factors for success and cumulative amount of energy (≤ 600 J vs > 600 J) were determined using multivariable logistic regression. A survival analysis was performed to determine risk factors for recurrence.

Results

Two hundred and thirty‐one TVEC procedures were included, with a 94.4% success rate and 31.9% recurrence rate (51/160). Mitral regurgitation (OR 0.151, 95% CI 0.032‐0.715, P = .02) and AF cycle length (OR 1.05, 95% CI 1.01‐1.09, P = .02) were independent determinants for success. Catheter type (OR 0.154, 95% CI 0.074‐0.322, P < .001), previous AF episode (OR 3.10, 95% CI 1.20‐8.01, P = .02), tricuspid regurgitation (OR 2.54, 95% CI 1.25‐5.13, P = .01), and body weight (OR 1.009, 95% CI 1.003‐1.015, P = .004) were significantly correlated with cumulative amount of energy delivered. Significant risk factors for recurrence after a first AF episode were sex (stallion; HR 3.05, 95% CI 1.34‐6.95, P = .008), mitral regurgitation (HR 1.91, 95% CI 1.08‐3.38, P = .03), and AF duration (HR 1.001, 95% CI 1.0001‐1.0026, P = .04).

Conclusions and Clinical Importance

Both horse and procedural factors should be considered when assessing treatment options and prognosis in horses with AF.
RNA-seq analysis of green tea polyphenols modulation of differently expressed genes in Enterococcus faecalis under low pH
Authors: Yan Ruonan , Zhou Huan , Zheng Xiaojie , Zhang Xin
Published: March 2022

Enterococcus faecasslis (E. faecalis) is a resident bacterium in the host. The increase in internal stress like low pH may affect the biological effects of E. faecalis. The prebiotic-like function of tea polyphenols can enhance the beneficial effects of its tolerance to environmental stress. In this study, RNA-sequence analysis was used to explore the protective effect of green tea polyphenols (GTP) on E. faecalis under low pH stress. A total of 28 genes were found to be responsive to GTP under low pH stress, including 16 up-regulated and 12 down-regulated. GTP intervention can partly relieve some undesired negative influences, such as the down-regulation of the base excision repair gene and amino acid transport and metabolism gene. The significantly changes were associated with selenocompound metabolism and aminoacyl-tRNA biosynthesis after the intervention of GTP. The present study provided new insights into the growth and continuous adaptation of E. faecalis under stress.
Variation in body mass and food intake of northern fur seals (Callorhinus ursinus)
Authors: McHuron Elizabeth A. , Rosen David A. S. , Carpenter Julie , Leonard Patricia , Sirpenski Gayle , Sterling Jeremy T.
Published: March 2022

Estimates of prey and energy consumption are important for effective management and conservation of marine mammals and the ecosystems they inhabit. We used routinely collected husbandry data on body mass, food intake (kilograms), and energy intake (megajoules) from northern fur seals (Callorhinus ursinus) in zoological institutions to examine how these variables changed throughout the year, and with age, sex, and reproduction. Fur seals exhibited seasonal changes in all three variables, but the magnitude and timing of trends varied among age and sex groups. Notably, adult males exhibited rapid increases in body mass leading up to the breeding season. Fur seals were most efficient at converting energy intake to mass gain in the spring and least efficient in the fall. Intake increased into adulthood as animals grew in body mass. Sex‐specific differences in intake were detectable early in development, likely related to size dimorphism. Pregnancy was energetically inexpensive compared with lactation, with food and energy intake rapidly increasing post parturition to values that were double those during early pregnancy. This study highlights the importance of accounting for different age, sex, and life history stages when estimating prey consumption of northern fur seals.
Anal sphincter fatigability in assessing anal incontinence: A systematic review
Authors: Wickramasinghe Dakshitha , Wickramasinghe Nilanka , Kamburugamuwa Sohan Anjana , Samarasekera Nandadeva , Warusavitarne Janindra , Vaizey Carolynne
Published: March 2022

Background

Diagnosing anal incontinence (AI) based on manometry results is challenging due to the variation of the normal values and overlap between patients with and without AI. This study aimed to perform a systematic review on the difference in sphincter fatigability between patients with and without AI.

Methods

MEDLINE, EMBASE, SCOPUS, and Google Scholar were searched. Studies were included if they included adult patients and assessed anal sphincter fatigability between using manometry. The effect size was estimated as the standardized mean difference (SMD) with 95% confidence intervals. A random‐effects model was used.

Results

The database searches identified 125 unique articles, and five additional articles were identified from the reference list of articles. One hundred thirteen were excluded through title and abstract review. Nine articles were included in the final analysis.

There was no statistically significant difference in the resting pressure between the two groups. Patients with AI had significantly lower squeeze pressure. There was no statistically significant difference between the groups in the fatigue rate.

The FRI was significantly lower in patients with AI (SMD 1.636, p = 0.001).

Approximately a third of the patients in one study were able to maintain a contraction for 20s without reducing pressure. There was significant heterogeneity in the studies. The data available were inadequate for more robust calculations.

Conclusions

Sphincter fatigability, measured by the Fatigability Rate Index, has good discriminating power for anal incontinence. A standardized protocol needs to be followed by future researchers.

Graphical Abstract

The analysis used six studies with 413 patients to compare Fatigue Rate Index between patients with AI and controls. All studies reported a lower FRI in patients with incontinence and the FRI was significantly lower in patients with AI (standardized mean difference [SMD] 1.636, p= 0.001). Conflicting results were reported on the correlation between FRI and AI symptom scores.
Transvaginal rectocoele repair for the surgical treatment of a “symptomatic” rectocoele when conservative measures fail: A 12 year experience of 215 patients
Authors: Ferrari Linda , Cuinas Karina , Hainsworth Alison , Darakhshan Amir , Schizas Alexis , Kelleher Cornelius , Williams Andrew Brian
Published: March 2022

Background

Conservative measures are first‐line treatment for a “symptomatic” rectocoele, while surgery to correct the anatomical defect may be considered in selected cases. The standard repair offered in our trust is a native tissue transvaginal rectocoele repair (TVRR) combined with levatorplasty. The primary aim of the study was to conduct a retrospective study to assess the outcome of this procedure, while secondary aims were to assess whether specific characteristics and symptoms were associated with response to surgery.

Methods

We conducted a retrospective review of 215 patients who underwent TVRR in a single tertiary referral center between 2006 and 2018. In total, 97% of patients had symptoms of obstructive defecation syndrome (ODS) and 81% had a feeling of vaginal prolapse/bulge. We recorded in‐hospital and 30 days post‐operative complications and pre‐ and post‐operative symptoms.

Key results

The majority of patients selected for surgery had rectocoele above 4 cm or medium size with contrast trapping. Mean length of hospital stay was 3.2 days. The in‐hospital complication rate was 11.2% with the most common complications being urinary retention (8.4%). Mean length of follow‐up was 12.7 months (SD 13.9, range 1.4–71.5) with global improvement of symptoms reported in 87.9% cases. Feeling of vaginal bulge improved in 80% of patients while ODS‐related symptoms improved in 58% of cases.

Conclusions & inferences

The data suggest that TVRR might be a valid option in patients with rectocoele when conservative treatment has failed. Overall patient satisfaction is good, with improvement of ODS symptoms.
Safety and efficacy of rapid drug desensitization in children
Authors: Esenboga Saliha , Akarsu Ayşegul , Ocak Melike , Gur Cetinkaya Pınar , Sahiner Umit Murat , Sekerel Bulent Enis , Soyer Ozge
Published: March 2022

Background

Any drug taken at the recommended dosage may cause hypersensitivity reactions (DHR). Rapid drug desensitization (RDD) protocols have been developed in the case of a confirmed or highly suspected HSR to allow safe administration of the medicine when there is no alternative drug or in the presence of a less effective or more toxic alternative. The aim of this study was to evaluate the characteristics of children who underwent desensitization, the safety and efficacy of RDD in children, as well as, the characteristics and management of breakthrough reactions.

Method

This retrospective study concerned children who underwent RDD due to physician‐diagnosed HSRs during or up to 48 hours after the infusion of various drugs between February 2010‐February 2021. Patients with a chronic disease needing chronic drug usage and acute infections seen in patients with chronic diseases were included. The results of RDD were documented.

Results

The study included 48 patients [8.1(IQR = 3.32–13.4) years, 60.4% male] with 58 HSRs of which 62.1% were classified as moderate and 5.2% as severe. Most of the patients were being treated for leukemia (41.7%), solid tumors (29.2%), and infections (6.3%). Skin tests were done for 41 out of 58 HSRs in 35 patients, and twenty of them were positive. A total of 269 RDDs were performed for 18 different drugs. Ninety percent of desensitizations were achieved with no reaction, and 3.7% and 5.6% with mild and moderate reactions, respectively. In multivariate analysis, skin test positivity was the only risk factor for breakthrough reactions (OR = 8.5, CI = 1.72–42.15, p = .009).

Conclusion

We demonstrated the safety and efficacy of RDD in childhood, thereby offered the first line treatment options to children with chronic diseases with hypersensitivity reactions (HSRs).
Degradation of oxalic acid produced by Botrytis elliptica infection in two ploidy levels of Lilium rosthornii Diels
Authors: Wang L. , Yan X. , Hu H. , Li J. , Jia G.
Published: March 2022

Oxalic acid (OA) is a crucial pathogenic factor for Sclerotinia spp. fungi, which is closely related to Botrytis spp. fungi. Whether OA is a pathogenic factor for the causal agent of grey mould in lily, Botrytis elliptica, and the response of lily to OA are poorly understood.

To address these questions, lesion tissues and deposition of calcium oxalate (CaOX) and callose were observed in diploid and tetraploid leaves of L. rosthornii after inoculation with B. elliptica. Oxalate oxidase (OXO) activity and the transcript levels of some genes related to OA degradation (LrGLP1, LrGLP2 and LrWRKY4), reactive oxygen species (ROS) production/scavenging systems (LrRBOHD, LrGST, LrPOD and LrAPX1) and pathogen‐related protein (PR) synthesis (LrCHI, LrBGL and LrPR10) were compared.

After diploid and tetraploid leaves inoculation, lesion tissue and callose and CaOX were separately observed around in guard cells and stomata rather than the epidermis in the infected area. OXO activity was triggered at 2 h post‐inoculation (hpi) in both ploidy leaves, and it was higher in the latter from 12‐48 hpi. Expression of LrGLP1, LrGLP2, LrRBOHD, LrGST, LrPOD, LrCHI, LrBGL and LrPR10 was higher in tetraploids than in diploids from 24(12)–36(48) hpi.

In conclusion, for B. elliptica, OA mainly chelates Ca2+ from the stomata cell wall. The strong capability to degrade OA and higher expression levels of some genes related to ROS accumulation/scavenging and PR synthesis may partially explain the relatively higher grey mould resistance of tetraploid L. rosthornii.
Prevalence of Berkeleyomyces basicola infections in black rot‐affected carrot determined using the MCM7 gene region
Authors: Cavalcante Suzilâine Y. S. , Veloso Josiene S. , Machado Alexandre R. , Câmara Marcos P. S. , Gomes André A. M.
Published: March 2022

Thielaviopsis and related taxa are responsible for losses in several agricultural crops. In carrot these pathogens can cause black rot, mainly after harvesting. Molecular studies using species‐specific DNA sequences are the principal tools for accurate identification of these pathogens. The objective of this work was to investigate which taxa are associated with black rot in carrot in Brazil using gene markers and Bayesian phylogenetic analysis. Eighteen isolates were obtained from carrots with symptoms of black rot. Through morphological characteristics all isolates were classified as Thielaviopsis‐like. Bayesian inference using only MCM7 sequences and a concatenated data set (LSU, MCM7 and 60S rRNA) allowed identification of all isolates as belonging to Berkeleyomyces basicola. All isolates induced black rot in carrot. Although our studies include a small number of isolates, the results indicate the likely predominance of B. basicola in causing black rot in carrot in Brazil, and that MCM7 sequences are enough to distinguish the Berkeleyomyces species by Bayesian inference.
Can blood progesterone concentration identify non‐pregnant buffaloes to support oestrous resynchronization?
Authors: Codognoto Viviane M. , Souza Fabiana F. , Salgado Letícia C. , Rizzoto Guilherme , Yamada Paulo H. , Marques Nayara F. S. , Carvalho Nélcio A. T. , Dantas Ariane , Mesquita Ana Victória Pereira , Ferreira João C. P. , Oba Eunice
Published: March 2022

This study compared the plasma progesterone concentrations from pregnant and non‐pregnant buffaloes to identify non‐pregnant females and submit cows earlier to oestrous resynchronization. Forty‐four multiparous mix‐breed Murrah buffaloes were selected for the study. The cows were subjected to hormonal oestrous synchronization and separated into 4 groups, P12 (pregnant, n = 8) and P18 (n = 8) at 12 and 18 days post‐insemination; NP12 (non‐pregnant, n = 7) and NP18 (n = 7) at 23 and 29 days after the onset of synchronization, respectively. The embryos and blood were collected, and the plasma was separated for centrifugation and used to determine progesterone concentration. Progesterone concentration was higher in P18 than P12 (p = .02) and NP18 groups (p < .001). The steroid was also increased in the P12 group compared with NP12 (p = .031). There was no difference between NP12 and NP18 (p = .906). We conclude that the plasma progesterone concentration can be an alternative to identify earlier non‐pregnant buffaloes, advancing the oestrous resynchronization or natural service to improve productivity.
Hit by the Silk Road: how wage coordination in Europe mitigates the China shock*
Authors: Barth Erling , Finseraas Henning , Kjelsrud Anders , Moene Kalle
Published: March 2022

Coordination in collective wage setting can constrain potential monopoly gains to unions in non‐tradable industries. Countries with national wage coordination can thus stabilize overall employment against fluctuations and shocks in the world economy. We investigate this argument by exploring within‐country variation in exposure to competition from China in 13 European countries. Our estimates demonstrate that in countries with uncoordinated wage setting, regions with higher import exposure experienced a marked fall in employment, while countries with wage coordination experienced no such employment effects. We show that our findings are robust to alternative measures of wage coordination, industry classifications, and trade exposure.
Educators’ Preferences for Professional Learning Formats by Learning Objective
Authors: LeVesseur Cheyne A. , Morrison Julie Q. , Nantais Melissa
Published: March 2022

Innovations in information technology have generated an array of options for the professional learning for educators. Face-to-face, remote, and hybrid formats for professional learning each have their advantages and disadvantages for advancing educators’ knowledge and skills in evidence-based practices to promote student achievement. The purpose of this study was to better understand teacher and educational leaders’ preferences for professional learning formats in relation to the intended learning objective. The results indicate that educators preferences for professional learning format varied by the intended learning objective of the session. Remote professional learning was preferred relative to face-to-face and hybrid formats for a session in which the primary objective was to share information uni-directionally from the presenter to the audience (53% versus 25% and 22% preferred hybrid). The respondents were equally split in their preference for either a face-to-face or remote format when the learning objective was to understand new concepts and learn how to apply the concepts to their setting. The results have important implications for designing professional learning.
ScannerS: parameter scans in extended scalar sectors
Authors: Mühlleitner Margarete , Sampaio Marco O. P. , Santos Rui , Wittbrodt Jonas
Published: March 2022

We present the public code that performs parameter scans and checks parameter points in theories beyond the Standard Model (BSM) with extended scalar sectors. incorporates theoretical and experimental constraints from many different sources in order to judge whether a parameter point is allowed or excluded at approximately $${95}{\%}~\text {{CL}}$$

95
%

CL

. The BSM models implemented in include many popular BSM models such as singlet extensions, different versions of the Two-Higgs-Doublet Model, or the different phases of the Next-to Two-Higgs-Doublet Model. The framework allows straightforward extensions by additional constraints and BSM models.
MOFs-DERIVED METAL OXIDES FOR FLEXIBLE SUPERCAPACITORS
Authors: SHARMA VIVEK , VASHISTHA VINOD KUMAR , DAS DIPAK KUMAR
Published: March 2022

As research on new technologies for the creation of flexible electrochemical energy storage systems continues, they are widely used in industries such as public portable devices, mobile electronics, and electronic products worldwide. Flexible supercapacitors (FSCs) are widely used in wearable electronics and medical fields, with high power density, excellent mechanical integrity and cycle stability. Researchers devoted a lot of time in recent years promoting several kinds of transition metal oxides (TMOs) for SCs. Organometallic frameworks (MOFs) are commonly utilized for the production of metal oxide-based electrodes for high-performance SCs as precursors or templates. These MOF-based metal oxides have a porous and adjustable structure, a large specific surface area, strong electrical conductivity, and good electrochemical stability, and they fulfil the specific capacitance and long-cycle power requirements of electrochemical double-layer capacitors. The latest developments in the production and application of MOF-derived metallic oxide compounds in FSCs are summarized in this study.
Association between Quantitative Classification of Renal Surface Nodularity and Early Renal Injury in Patients with Arterial Hypertension
Authors: Zhou Jun , Ding Jiule , Chen Jie , Wu Qiong , Xiang Dehui , Xing Wei
Published: March 2022

Background. This study sought to explore the association between quantitative classification of renal surface nodularity (qRSN) based on computed tomography (CT) imaging and early renal injury (ERI) in patients with arterial hypertension. Methods. A total of 143 patients with a history of hypertension were retrospectively enrolled; clinical information (age, sex, hypertension grade, and hypertension course), laboratory tests, and qRSN were collected or assessed. The subjects were divided into an ERI group (n = 60) or a control group (CP, n = 83) according to ERI diagnosis based on the following criteria: cystatin C > 1.02 mg/L. Univariate analysis and multiple logistic regression were used to assess the association between ERI and qRSN. A receiver operating characteristic curve (ROC) was performed to compare multiple logistic regression models with or without qRSN for differentiating the ERI group from the control group. Results. In univariate analysis, hypertension grade, hypertension course, triglycerides (TG), and qRSN were related to ERI in patients with arterial hypertension (all

P
<
0.1

), with strong interrater agreement of qRSN. Multiple logistic regression analysis showed an area under the ROC curve of 0.697 in the model without qRSN and 0.790 in the model with qRSN, which was significantly different (Z = 2.314,

P
=
0.021

). Conclusion. CT imaging-based qRSN was associated with ERI in patients with arterial hypertension and may be an imaging biomarker of early renal injury.
Financial Market Sentiment Prediction Technology and Application Based on Deep Learning Model
Authors: Guo Yixuan
Published: March 2022

In the real world, there are a variety of situations that require strategy control, that is reinforcement learning, as a method for studying the decision-making and behavioral strategies of intelligence. It has received a lot of research and empirical evidence on its functions and roles and is also a method recognized by scholars. Among them, combining reinforcement learning with sentiment analysis is an important theoretical research direction, but so far there is still relatively little research work about it, and it still has the problems of poor application effect and low accuracy rate. Therefore, in this study, we use the features related to sentiment analysis and deep reinforcement learning and use various algorithms for optimization to deal with the above problems. In this study, a sentiment analysis method incorporating knowledge graphs is designed using the characteristics of the stock trading market. A deep reinforcement learning investment trading strategy algorithm for sentiment analysis combined with knowledge graphs from this study is used in the subsequent experiments. The deep reinforcement learning system combining sentiment analysis and knowledge graph implemented in this study not only analyzes the algorithm from the theoretical aspect but also simulates data from the stock exchange market for experimental comparison and analysis. The experimental results illustrate that the deep reinforcement learning algorithm combining sentiment analysis and knowledge graphs used in this study can achieve better gains than the existing traditional reinforcement learning algorithms and has better practical application value.
Sweet Wormwood and Tortoise Shell Decoction (Thanh Hao Miet Giap Thang) Induces DNA Damage, S-Phase Arrest, and Apoptosis in MCF-7 Cells via ATR-CHK1 Signaling Pathway
Authors: Nguyen Thai Hoang Tam , Nguyen Thuy Vy , Ho Huynh Thuy Duong
Published: March 2022

Introduction. Sweet wormwood and tortoise shell decoction, Thanh Hao Miet Giap Thang (THMGT) in Vietnamese, a traditional formula composed of five ingredients, is used in complementary care in Vietnam for patients who underwent conventional cancer treatment. To expand the clinical use and explore novel functions of THMGT, this study was conducted to investigate the effect of THMGT in terms of antiproliferative activity and selective cytotoxicity toward human breast cancer cells MCF-7. Methods. Cytotoxicity of THMGT against human breast cancer cells MCF-7 and primary fibroblasts from a heathy donor were studied using sulforhodamine B (SRB) assay. Flow cytometry analysis, immunofluorescence, and western blotting were also performed to elucidate underlying mechanisms of THMGT action. Results. The SRB assay on treated MCF-7 cells and primary fibroblasts from a heathy donor indicated selective cytotoxicity of THMGT with a selective index of 3.92. Annexin V/PI staining and flow cytometric analysis on stained MCF-7 cells showed that the THMGT-treated cells were arrested at the S phase and subsequently underwent apoptosis. Western blot analysis showed an upregulation of γ-H2AX, increased protein levels of phosphorylated CHK1, TP53, and phosphorylated TP53 in a time-dependent manner, and a downregulated expression of ATR and MDM2. Conclusion. These results suggested DNA damaging effect and ATR-CHK1-mediated cell cycle arrest of THMGT on MCF-7 cells resulting in apoptosis induction.
Motivation, Perception, and Behavior of the Adult Orthodontic Patient: A Survey Analysis
Authors: Saccomanno S. , Saran S. , Laganà D. , Mastrapasqua R. F. , Grippaudo C.
Published: March 2022

Purpose. The article is aimed at improving the understanding of the sociocultural profile of adult orthodontic patients and their expectations. In particular, it addresses three main aspects: the motivation and needs that underpin the decision to start orthodontic treatment, how it influences the patients’ daily life, and the different oral hygiene demands. Materials and Methods. An online survey was completed by 276 patients undergoing orthodontic treatment with different techniques. The questions asked concerned gender, age, type of appliance, any previous orthodontic treatments, type of any previous retainers, reasons for therapy, satisfaction, pain, problems in eating, daily number of teeth brushings and flossings before and during the treatment, perception of cost, sensation of visibility of the appliance, and if they would recommend orthodontic treatment. Results. A significant role within our sample is played by gender; 87.94% consisted of female patients out of which 72.57% wanted to improve their aesthetics, while only 54.84% of male patients cited the same reason. Invisible aligners were preferred by 67.70% of the patients due to them being considered the least painful, causing the fewest problems with eating, and the least visible. Metal braces were perceived as the less expensive treatment. Over a third of the patients (33.85%) had previously undergone orthodontic treatment, among them 54.05% wore a mobile retainer, 31.08% a fixed one, and 14.86% both. Daily tooth brushing and flossing increased during therapy with clear aligners by 48.94% and 126.39%, respectively. Conclusions. The greatest demand for orthodontic treatments comes from women, as they pay more attention to aesthetics, which makes the clear aligners the most common choice. The relapse after orthodontic treatment seems to cause a higher demand for retreatment, and oral hygiene habits significantly improve during orthodontic treatment, especially with the clear aligners.
Estimating Fixed Points via New Iterative Scheme with an Application
Authors: Jubair Mohd , Ali Javid , Kumar Santosh
Published: March 2022

In this paper, we introduce a new scheme and prove convergence results for nonexpansive mappings as well as for weak contractions in the frame of Banach spaces. Moreover, we prove analytically and numerically that the proposed scheme converges to a fixed point of a weak contraction faster than some known and leading schemes. Further, we prove that the new scheme is almost stable with respect to weak contraction. For supporting the main results, we give a couple of nontrivial numerical examples, and the visualization is shown by using the Matlab program. Finally, the solution of a nonlinear fractional differential equation is approximated by operating the main result of the paper.
Effect of Repeated Weld Repairs on Microstructure and Mechanical Properties of Heat-Affected Zone in CA6NM Stainless Steel
Authors: Liu Peng , Ma Jien , Fang Youtong , Xu Bowen , Qiu Lin
Published: March 2022

The low-carbon martensitic stainless steel CA6NM is widely used in the impellers of hydroelectric and nuclear power units due to its advantages of high hardness, corrosion fatigue strength, and good fracture toughness. In order to analyze the number of repair welding times on the properties of heat-affected zone (HAZ, the most unstable area of welded joint property) in CA6NM, the microstructure and mechanical properties of HAZ with once-repaired welds (1R) and twice-repaired welds (2R) were tested. Through data analysis, the following conclusions are drawn for welded joints: (1) the grain size of HAZ with a different number of repair welding processes is smaller than that of the base material; (2) the density of texture concentration is reduced and the directionality is not obvious; (3) the density of twins and dislocations are increased; (4) the hardness and impact energy of HAZ of the 1R and 2R specimens are higher than that of the base material.
Automated Particle Shape Identification and Quantification for DEM Simulation of Rockfill Materials in Subgrade Construction
Authors: Bai Hao , Hu Xiangyu , Li Ruidong , Chen Fei , Liao Zhiyong
Published: March 2022

Rockfill materials, conducted by impermeable stone, are frequently used in subgrade construction projects. The irregularity and variability of particle shape are demonstrated to affect the mechanical properties of rockfill subgrade, such as void ratio and coordination number. This study first identifies the subgrade rockfill particle contour by machine learning algorithms, including AdaBoost, Cascade, and sliding windows. Then, the shape evaluation indexes of length flatness, edge angle, and roughness are quantified, and the statistical analysis of each index is presented. In addition, the discrete element method (DEM) simulation is implemented on the compaction of rockfill subgrade to explore the impact of roundness on characteristics of particles. Finally, the macroanalysis on the void ratio and cumulative settlement and the microanalysis on particle coordination number, rotation momentum, and displacement are studied. The results illustrate that roundness has a significant effect on the mechanical characteristics of subgrade rockfill materials. With the increase of rolling passes, the porosity of packing decreases, whereas the settlement increases gradually. The change rate starts fast and ends slowly.
Expression Profiles of Exosomal MicroRNAs Derived from Cerebrospinal Fluid in Patients with Congenital Hydrocephalus Determined by MicroRNA Sequencing
Authors: Chen Shiyu , Li Hao , Zheng Jicui , Hao Lili , Jing Tianrui , Wu Peixuan , Zhang Bowen , Ma Duan , Zhang Jing , Ma Jing
Published: March 2022

Purpose. Congenital hydrocephalus is one of the most common birth defects worldwide. Exosomal microRNAs (miRNAs) in body fluids have been implicated in many diseases. However, their involvement in cerebrospinal fluid from congenital hydrocephalus is not well understood. This study is aimed at investigating the role of dysregulated exosomal miRNAs in congenital hydrocephalus. Methods. We collected cerebrospinal fluid samples from 15 congenital hydrocephalus patients and 21 control subjects. We used miRNA sequencing to generate exosomal miRNA expression profiles in three pairs of samples. We identified 31 differentially expressed exosomal miRNAs in congenital hydrocephalus and predicted their target mRNAs. Results. Three microRNAs (hsa-miR-130b-3p, hsa-miR-501-5p, and hsa-miR-2113) were selected according to their fold changes and the function of their target mRNAs, and only hsa-miR-130b-3p and hsa-miR-501-5p were confirmed their expression levels in all samples. Moreover, upregulated hsa-miR-130b-3p might mediate the downregulation of the phosphatase and tensin homolog gene (PTEN), which has been associated with hydrocephalus, via binding to its 3

′

-untranslated region by dual-luciferase reporter assay. Conclusion. This study implicates that abnormally expressed exosomal miRNAs in cerebrospinal fluid may be involved in the pathomechanism of congenital hydrocephalus.
Living with Atrial Fibrillation: A Family Perspective
Authors: Rosenstrøm Stine , Risom Signe Stelling , Hove Jens Dahlgaard , Brødsgaard Anne
Published: March 2022

Aim. The aim of this study was to obtain insights from patients and their family members on how families are living with atrial fibrillation. Background. Atrial fibrillation is the most common cardiac arrhythmia and is often described as an emerging global epidemic affecting an estimated 33.5 million people worldwide. Living with atrial fibrillation not only affects the patient but also may negatively influence family members’ perceived health. The perspective of the family has previously been understudied, and more knowledge on how patients and their family members cope and adjust to life with atrial fibrillation may be helpful when developing future support for patients and their family members when coping with atrial fibrillation. Methods. A qualitative phenomenological study with an inductive, descriptive research approach based on Giorgi’s descriptive method was used. Data were gathered through 12 dyadic family interviews. The COnsolidated criteria for REporting Qualitative research checklist was followed while conducting the study. Results. Three major themes emerged: emotional differences, changes in family life, and uncertainty about the future. Atrial fibrillation had multiple effects on the family. Frequently, several adjustments and adaptations had to be made to accommodate life with atrial fibrillation. Conclusion. Patients with atrial fibrillation and their family members feel a need to talk about their emotions and worries. They required support and guidance to manage the challenges of living with atrial fibrillation. These results will be used in a family-focused intervention designed to support families in adjusting and managing their everyday lives with atrial fibrillation.
Penetrating Power of High-Density Tungsten Fiber/Zr-Based Metallic Glass Matrix Composite
Authors: Zou Minming , Guo Min , Ye Xianghai
Published: March 2022

Tungsten-fiber/Zr-based metallic glass (Zr41.25Ti13.75Cu12.5Ni10Be22.5) matrix composite (hereinafter referred to as WF/Zr-MG composite) is considered a potential new generation of projectile material, while the density of WF/Zr-MG composite is usually around 16.5 g/cm3 and it is difficult to exceed 17.0 g/cm3. To understand the penetration performance of the composite material, a penetration test was performed on high-density WF/Zr-MG composite with a density of 17.1 g/cm3. The penetration depth, the diameter of the crater, morphology, and microstructure have been studied in a residual high-density WF/Zr-MG composite penetrator. A total of 8 penetration tests were performed by firing the projectiles into 603 steel targets based on the 30 mm ballistic gun, which included five high-density WF/Zr-MG composite projectiles and three 93W projectiles. Then, the target was cut through the crater using a wire cutting machine into a sample with 80 mm × 40 mm × 20 mm, which was polished by different types of sandpaper. The microstructures were characterized and analyzed by SEM and TEM technology. According to this study, high-density WF/Zr-MG composite penetrators perforated the target with a thickness of 69.7 mm on average, which is about 19.8% better than 93W alloy (58.2 mm) when the impact velocity is 1400 ± 20 m/s. Meanwhile, the high-density WF/Zr-MG composites exhibited “self-sharpening” behavior in the penetration process. Moreover, the higher penetrating power of high-density WF/Zr-MG composite is attributed to its higher dynamic compressive strength and “self⁃sharpening” behavior during penetration.
Coal and Gas Comining in the High‐Gas Detong Mine, China: Analytical and Numerical Parameter Optimization of Gas Extraction Boreholes
Authors: Wang Wei , Li Zongxiang , Zhao Guangmin , Chen Yujin
Published: March 2022

The upper corner gas overrun caused by goaf gas gushing in the high‐gas mine can be mitigated by roof positioning of long boreholes in the goaf fracture zone, creating an artificial gas migration channel and achieving safe comining of coal and gas. This study numerically simulated the fracture evolution in the coal rock overlying goaf in workface #2‐104 of the Detong Mine, China. Using the O‐shaped circle theory and the FLAC3D commercial software package, the range parameters of goaf fracture zone gas‐concentrated areas were obtained by defining the pressure relief coefficient, which provided a basis for the arrangement of holes in the goaf located at 15 m from the workface goaf collapse zone to the workface floor and 15–60 m from the structure zone to the workface. According to the obtained goaf parameters, the distribution and migration law in the goaf under the conditions of initial state and extraction with different roof borehole parameters were simulated by the FLUENT software. The optimal borehole location was 30 m from the floor and 25 m from the return airway. The field experiment with three boreholes arranged in the optimal extraction position provided the extraction concentration in the borehole above 30%, the gas extraction volume of 12 m3·min−1, and the concentration at the upper corner below 1%, which ensured safe coal and gas comining.
Questões de tradução para legendagem e aprendizagem de alemão como língua estrangeira: o caso das legendas da série Dark
Authors: Bolacio Filho Ebal Sant'Anna , Moraes Maria Eduarda Reinheimer , Araújo Dionelle , Mello Gabriela de Mendonça
Published: March 2022

A partir dos resultados de uma pesquisa online realizada com aprendizes de alemão no Brasil sobre suas experiências com legendagem, na qual a série Dark se destacou como sendo mais conhecida, constatou-se que as legendas em português são consideradas pelos aprendizes um recurso útil para a aprendizagem autônoma fora do contexto de sala de aula. O presente artigo tem como objetivo analisar a tradução para legendagem e dublagem da primeira temporada da referida série a fim de constatar as diferenças entre elas e quais seriam as características do texto proposto pela legendagem, diante das discussões sobre as supostas perdas sofridas no processo de tradução para legendagem (Fois 2020: 222-223). Após a análise das traduções da série Dark e da discussão teórica sobre as diferenças entre tradução para dublagem e tradução para legendagem, concluiu-se que, apesar do caráter mais conciso e de menos oralidade da tradução para legendagem, as legendas podem ser uma base para a comparação com o texto do áudio original e auxiliar assim no trabalho autônomo de aprendizagem de vocabulário.
A abordagem CLIL na graduação em Letras/Alemão: pontes possíveis
Authors: Grilli Marina
Published: March 2022

Este trabalho retoma pontos da pesquisa de mestrado da autora (Grilli 2018) e tem como objetivo explorar o conceito de Ensino Integrado de Língua e Conteúdo (CLIL) e suas possíveis aplicações nos cursos de graduação em Letras/Alemão brasileiros. Na primeira seção, são apresentadas a história daquilo a que chamamos ensino bilíngue e as principais características da abordagem CLIL. Na segunda seção, voltada à realidade brasileira, são recuperadas as diretrizes que regem a educação bilíngue em nosso país, e os documentos que regem os cursos de Letras/Alemão. Maior foco é conferido à USP, instituição na qual foi realizada a pesquisa empírica aqui descrita e discutida, que se ocupa das dificuldades percebidas ao longo do curso por egressos. Após apresentar os resultados da pesquisa, discute-se como unir a teoria do CLIL à realidade dos cursos de Letras/Alemão no Brasil, relacionando as cinco dimensões do CLIL e a taxonomia de Bloom à grade curricular desses cursos. Na conclusão, defende-se que um trabalho baseado na abordagem CLIL pode conferir aos graduandos maior autonomia no uso da língua alemã em todas as suas dimensões, e, consequentemente, maior autonomia em seu futuro trabalho docente.
Interlíngua x translinguajar: diferenças e intersecções dos conceitos
Authors: Araújo Filho Marcos Antônio Alves
Published: March 2022

Este artigo aponta aproximações e diferenças conceituais de dois termos essenciais nos estudos de aprendizagem / aquisição de segunda língua na atualidade: a interlíngua (Selinker 1972) e o translinguajar (García 2009). A partir de um pequeno corpus composto de seis artigos, coletados de três revistas acadêmicas brasileiras, foi possível conhecer o contexto em que os termos são usados e encontrar características que os definem e ao mesmo tempo os distinguem. Os resultados indicam apenas uma congruência: o fato de serem línguas em construção, constituídas de elementos da língua materna ou da própria língua adicional, ou até mesmo de outras línguas.