bluuebunny/crossref_metadata_2025 huggingface dataset:
CNTNAP3 is a differentially expressed gene in brain metastatic human breast cancer.
Authors: Mamoor Shahan
Published: February 2021

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that contactin associated protein-like 3, encoded by CNTNAP3, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. CNTNAP3 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Modulation of CNTNAP3 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Decontamination Interventions for the Reuse of Surgical Mask Personal Protective Equipment: A Protocol for an Updated Systematic Review
Authors: Zorko David J , Choong Karen , McNally James Dayre , O'Hearn Katie , Sikora Lindsey , Dinh Tri , Gibson Jess
Published: February 2021

The COVID-19 pandemic has placed surgical and medical facemask PPE in high demand. Their use spans a variety of healthcare settings and many hospitals have implemented universal masking policies. Furthermore, the emergence of COVID-19 variants with greater transmissibility and infectivity has led some countries to recommend or mandate widespread public use of 3-layer medical masks in lieu of homemade masks or face coverings. Since the publication of our original systematic review, COVID-19-related literature has evolved from >2000 citations in mid-March 2020 to >80,000 citations by the beginning of December 2020. Coupled with the protracted course of the COVID-19 pandemic continuing to threaten facemask PPE supply and demand, an updated systematic review on decontamination interventions for surgical masks is needed to reflect critical new evidence in order to best inform clinicians, infection control experts, and public health administrators on how best to advise safe decontamination and reuse practices. The objective of this systematic review is to update a previously conducted systematic review and identify and synthesize new data from published studies evaluating interventions used to decontaminate or treat surgical mask PPE for the purposes of reuse.
MENANAMKAN KONSEP MULTIKULTURALISME DI INDONESIA
Authors: Kardiman
Published: February 2021

Keragaman merupakan salah satu pola kehidupan sosial, dan hal ini tidak dapat dihindari. Indonesia sebagai negara majemuk membutuhkan sistem nilai yang dapat menjadikan hal ini menjadi keanekaragaman yang unik jika dikelola dengan baik, namun bila tidak dikelola dengan baik maka tantangan besar yang diberikan akan menimbulkan permasalahan seperti konflik sosial, konflik horizontal dan disintegrasi bangsa. Ideologi Pancasila sebagai bangsa belum mampu mewujudkan kehidupan multikultural, sehingga diperlukan pendidikan multikulturalisme agar nilai-nilai yang terkandung dalam Pancasila dan “Bhineka Tunggal Ika” dapat terwujud.
Simulation and analyze a production line by using Arena: A case study
Authors: Rashidifar Rasoul
Published: February 2021

In many companies and manufacturing systems, Managers and engineers are looking for methods to find problems their production line like bottleneck so that they eliminate them whereas they want to obtain more productivity at the same time. Simulation is an appropriate tool to find and catch this purpose. In this project, a simulation computer is applied on a line production in Visionwork as a case study and by considering information obtained from simulation, bottleneck is determined, generating station and hand washing station. Then to increase productivity, two recommendation is proposed, both of them is investigated so that to find which bottleneck is more critical. Results shows that by increasing the machine in generating station and increasing labor in washing hand station, the company would be able to achieve higher utilization by 25% than the current system.
The effect of delay duration on delay discounting across adulthood
Authors: Leverett Shelby , Garza Christopher , Seaman Kendra Leigh
Published: February 2021

Literature about the relationship between age and delay discounting, or the willingness to wait for delayed rewards, is mixed. We posit that some of this heterogeneity may be attributable to inconsistent delay durations across studies. Here we investigate how delay duration influences discounting across adulthood by systematically varying the duration of the delay between the smaller, sooner and the larger, later option. 288 healthy participants (Age range: 25-84 years) completed an online delay-discounting task that probed 12 different time delays across 3 discount rates. Discounting was analyzed in two statistical models that treated delay duration as either a categorical or a continuous predictor. Longer delays were generally associated with decreased discounting. However, this was dependent on both age of the participant and delay duration. Both models revealed that, at short to moderate time delays, older adults discounted less than younger adults. However, at very long delays (5 and 10 years), older adults discounted at similar rates to younger adults. Results suggest older adults may discount more than younger adults only for extremely long delays (> 10 years). Future research should investigate if this reversal in discounting exists, why it exists, and where the inflection point lies.
Changing Personality Traits with the Help of a Digital Personality Change Intervention
Authors: Stieger Mirjam , Flückiger Christoph , Rüegger Dominik , Kowatsch Tobias , Roberts Brent , Allemand Mathias
Published: February 2021

Personality traits predict important life outcomes such as success in love and work life, wellbeing, health, and longevity. Given these positive relations to important outcomes, economists, policy-makers, and scientists have proposed intervening to change personality traits to promote positive life outcomes. However, non-clinical interventions to change personality traits are lacking so far in large-scale naturalistic populations. This study (N = 1,523) examined the effects of a 3- month digital personality change intervention using a randomized controlled trial (RCT) and the smartphone application PEACH (PErsonality coACH). Participants who received the intervention showed greater self-reported changes compared to participants in the waitlist control group who had to wait one month before receiving the intervention. Self-reported changes aligned with intended goals for change and were significant for those desiring to increase on a trait (d = 0.52) and for those desiring to decrease on a trait (d = -0.58). Observers such as friends, family members or intimate partners also detected significant personality changes in the desired direction for those desiring to increase on a trait (d = 0.35). Observer-reported changes for those desiring to decrease on a trait were not significant (d = -0.22). Moreover, self- and observer reported changes persisted until three months after the end of the intervention. This work provides the strongest evidence to date that normal personality traits can be changed through intervention in non-clinical samples.
Jual Obat Aborsi Medan Wa 081333960089 Apotik Jual Cytotec Asli Di Medan
Authors: halomuji
Published: February 2021

Obat Aborsi Medan 0813 3396 0089 | Jual Obat Aborsi | Obat Aborsi Cytotec | Obat Telat Bulan | Obat Pelancar Haid | Obat Penggugur KandunganAPOTIK : Kami Jual Obat Aborsi Cytotec Hub : 0813 3396 0089 | Jual Obat Aborsi Cytotec| Obat Penggugur Kandungan Cytotec | Obat Pelancar Haid Tuntas. Dengan harga yang bisa anda pilih sesuai usia kandungan anda. Obat yang kami jual ampuh dan tuntas untuk menunda kehamilan atau proses aborsi untuk usia kandungan 1– 6 BulanApa itu Aborsi ?“Abortion Adalah dengan membendung hormon yang di perlukan untuk mempertahankan kehamilan yaitu hormon progesterone, karena hormon ini di bendung, maka jalur kehamilan mulai membuka dan leher rahim menjadi melunak, sehingga mulai mengeluarkan darah yang merupakan tanda bahwa obat telah bekerja (maksimal 1 jam sejak obat diminum) darah inilah yang kemudian menjadi pertanda bahwa pasien telah mengalami menstruasinya, sehingga secara otomatis kandungan di dalamnya telah hilang dengan sendirinya 100% berhasil…OBAT ABORSI AMPUH USIA 1-6 BULANObat Aborsi Cytotec | Jual Obat Aborsi | Obat Aborsi Ampuh| Obat Aborsi Asli | Obat Pelancar Haid | Obat Penggugur KandunganKAMI JUAL OBAT ABORSI MEMBERI GARANSI 100%.
Jual Obat Aborsi Tulungagung Wa 081333960089 Apotik Jual Cytotec Asli Di Tulungagung
Authors: halomuji
Published: February 2021

Obat Aborsi Tulungagung 0813 3396 0089 | Jual Obat Aborsi | Obat Aborsi Cytotec | Obat Telat Bulan | Obat Pelancar Haid | Obat Penggugur KandunganAPOTIK : Kami Jual Obat Aborsi Cytotec Hub : 0813 3396 0089 | Jual Obat Aborsi Cytotec| Obat Penggugur Kandungan Cytotec | Obat Pelancar Haid Tuntas. Dengan harga yang bisa anda pilih sesuai usia kandungan anda. Obat yang kami jual ampuh dan tuntas untuk menunda kehamilan atau proses aborsi untuk usia kandungan 1– 6 BulanApa itu Aborsi ?“Abortion Adalah dengan membendung hormon yang di perlukan untuk mempertahankan kehamilan yaitu hormon progesterone, karena hormon ini di bendung, maka jalur kehamilan mulai membuka dan leher rahim menjadi melunak, sehingga mulai mengeluarkan darah yang merupakan tanda bahwa obat telah bekerja (maksimal 1 jam sejak obat diminum) darah inilah yang kemudian menjadi pertanda bahwa pasien telah mengalami menstruasinya, sehingga secara otomatis kandungan di dalamnya telah hilang dengan sendirinya 100% berhasil…OBAT ABORSI AMPUH USIA 1-6 BULANObat Aborsi Cytotec | Jual Obat Aborsi | Obat Aborsi Ampuh| Obat Aborsi Asli | Obat Pelancar Haid | Obat Penggugur KandunganKAMI JUAL OBAT ABORSI MEMBERI GARANSI 100%.
Antibacterial Activity of Common Spices Extracts on Bacterial Isolates found in Kachhila, a Newari Cuisine
Authors: Sah Shiv Nandan , Khanal Hemanta , Acharya Dev Raj
Published: February 2021

Objectives: The objective of this study was to determine the antibacterial property of aqueous extracts of common spices used in the preparation of Kachhila such as garlic, ginger, and turmeric.

Methods: After washing and cleaning separately, aqueous extracts were extracted from each spice by crushed with mortar and pestle. Antibacterial activity of aqueous extracts of each spice was evaluated by using agar well diffusion assay and paper disc diffusion assay against test bacteria isolated from buff meat used in Kachhila preparation.

Results: Minimum inhibition concentration value of each spice was evaluated against all bacterial isolates. Total bacterial count (CFU/g) of prepared Kachhila was determined in each 30 mins interval up to 150 mins to reveal antibacterial activities of spices used in Kachhila. The antibacterial effect of aqueous extract of garlic extract was found to be the stronger in comparison, followed by turmeric and ginger against test bacterial isolates. The MIC of individual spice extract was found to be 125 to 4000 μl/ml against all the test bacteria. Spices used in Kachhila revealed that bacterial load decreased with time due to the antibacterial property of spices.

Conclusion: This study concluded that the antibacterial effect of aqueous extract of Garlic extract was stronger in comparison, followed by Turmeric and Ginger against four test bacteria isolated from buff meat namely; E. coli, Salmonella spp., Pseudomonas spp., Staphylococcus aureus. Therefore this study revealed that spices used in Kachhila have an antibacterial property and enhance the shelf life of Kachhila.
Phenotypic detection of Extended Spectrum Beta lactamase production from E. coli and K. pneumoniae in urinary samples among children
Authors: Subedi Kalyan , Karki Farisna , Lama Sanju , Pandey Agya , Dahal Unita , Paudyal Rabin
Published: February 2021

Objectives: The main objective of this study was to detect antimicrobial drug resistance (AMR) and Extended Spectrum Betalactamase (ESBL) production phenotypically in E. coli and K. pneumoniae isolated from urines with significant bacteriuria.

Methods: This cross-sectional study was carried out in Microbiology laboratory of Kathmandu College of Science and Technology, Kamalpokhari. The urine samples from suspected urinary tract infected cases were collected from both genders of children below 15 years of age from Out and In-patient department of International Children Friendship Hospital, Maharajgunj and those with significant bacteriuria were cultured for isolating the bacterial etiology targeted as E. coli and K. pneumoniae. AMR for these two bacteria were tested and detected using Kirby Bauer Disc Diffusion technique. ESBL production was confirmed by Double Disc Synergy test (DDST) and Phenotypic Confirmatory Disc Diffusion Test (PCDDT) after screening for all the isolates showing resistance to third generation cephalosporin namely Cefotaxime and Ceftriaxone according to CLSI instructions.

Results: Out of 388 urine samples processed, 29.89% (116/388) showed significant bacterial growth. Five (5) different Aerobic Gram Negative bacterial species were detected and identified. E. coli topped the list (70.68%) followed by K. pneumoniae (15.52%), K. oxytoca (8.62%), Proteus vulgaris (3.45%) and Pseudomonas aeruginosa (1.73%). Among positively screened (44.82%) beta lactamase producers (36.2%) of total isolates were confirmed to produce ESBL. Among ESBL producing isolates, highest susceptibility was seen to Ceftazidime (23.80%) followed by Cefotaxime (16.67%). The ESBL producing isolates were least susceptible to Ceftriaxone (2.38%). AMR was detected using Kirby- Bauer Disc diffusion technique. Comparatively less resistance to amikacin and nitrofurantoin (19.1% and 9.53% respectively) was seen among ESBL producers. 40 out of the 42 (95.23%) ESBL producing strains showed susceptibility to the combination drug, piperacillin/tazobactam. The resistance to meropenem was observed to be less (9.53%) as compared to that to imepenem (7.15%).

Conclusion: This study concluded that there is high prevalence of multidrug resistant uropathogenic clinical strains of E. coli and K. pneumoniae with higher rates of ESBL production. A resistance to the carbepenems is also emerging. Appropriate antimicrobial regimen selection for empirical therapy is thus important for such cases. On managing the empirical antibiotics practice, one can reduce the risk of ESBL producers. There is an essence need of regular routine practice of ESBL detection.
Identifikasi Faktor Risiko, Dampak dan Intervensi Kecemasan Menghadapi Persalinan pada Ibu Hamil Trimester Ketiga
Authors: Isnaini Irma , Hayati Elli Nur , Bashori Khoiruddin
Published: February 2021

Tinjauan ini bertujuan untuk menyelidiki kecemasan ibu menghadapi persalinan, dan mendeskripsikan faktor risiko, dampak buruk yang ditimbulkan, serta menyelidiki intervensi yang dapat digunakan untuk mengurangi kecemasan. Kecemasan menghadapi persalinan penting untuk dikaji, karena kecemasan yang berlebihan selama kehamilan dapat menimbulkan efek buruk baik bagi ibu maupun bayinya. Metode tinjauan literatur digunakan untuk mengumpulkan materi yang relevan tentang topik ini. Review literatur ini menemukan bahwa faktor usia dan paritas menjadi faktor risiko yang utama. Kecemasan yang berlebihan selama kehamilan dapat mengakibatkan stres dan depresi. Ibu yang memiliki kecemasan berlebihan cenderung melahirkan bayi prematur serta memiliki gangguan dalam pertumbuhan dan perkembangannya. Secara umum, musik, Al-Qur’an dan relaksasi dapat menjadi intervensi dalam mengatasi kecemasan tersebut.
Efektivitas Pelatihan Regulasi Emosi untuk Menurunkan Perilaku Bullying pada Siswa SMP
Authors: Rahmadhony Samurya
Published: February 2021

Undang-Undang No. 20 Thn. 2003 Bab V pasal 12 ayat 2 menjelaskan setiap peserta didik diwajibkan menjaga norma-norma pendidikan untuk menjamin keberlangsungan proses dan keberhasilan pendidikan. Sebanyak 83% pelajar Surabaya mengetahui adanya perilaku bullying. Regulasi emosi merupakan suatu kemampuan untuk tenang dan fokus dalam mengevaluasi reaksi emosional. Penelitian ini merupakan penelitian kuantitatif dengan metode eksperimen. Desain penelitian yang dilakukan adalah one group pretest-posttest design. Subjek dipilih dengan cara purposive sampling. Subjek yang terlibat yakni 28 orang siswa kelas IX B SMPN ABC Surabaya. Subjek menjalani 7 sesi ditambah prasesi pelatihan yang dilaksanakan selama 2 hari. Data yang terkumpul dianalisis dengan paired sample t-test dan effect size. Hasilnya menunjukkan bahwa pelatihan regulasi emosi efektif dan memberikan efek yang besar untuk menurunkan perilaku bullying pada siswa kelas IX B SMP ABC Surabaya.
Pemanfaatan Carousell untuk Bisnis Online pada Ibu-Ibu di Sekitar PKBM Ar Rosyid Purwokerto
Authors: Andina Anisa Nur , Miranti Adita , Barokah Siti , Girsang Arista Apriani , Nur Afifah Rizki Aprilia
Published: February 2021

Berjualan online saat ini telah menjadi pilihan masyarakat Indonesia. Disamping menghemat waktu, berjualan online juga lebih mudah dan murah. Dikatakan murah karena penjual tidak perlu mempunyai toko fisik yang jelas menghemat biaya untuk sewa ruang, dikatakan mudah karena penjual bisa kapan pun berjualan tanpa terbatas waktu. Carousell merupakan salah satu marketplace yang belum banyak dikenal oleh masyarakat di Indonesia. Dalam hal ini penjualan melalui online sangat diminati oleh masyarakat, disamping mudah juga lebih cepat pada target sasaran. Pengabdian kepada masyarakat yang dilakukan di PKBM Ar Rosyid adalah untuk memperkenalkan Carousell kepada ibu-ibu agar bisa dimanfaatkan sebagai sarana untuk berjualan secara online dengan mudah dan cepat. Metode yang digunakan adalah sosialisasi dan pelatihan yang dilakukan oleh tim dosen bersama mahasiswa. Hasil penelitian menunjukkan bahwa ibu-ibu di lingkungan Ar Rosyid sangat antusias dalam belajar berjualan online menggunakan Carousell dan sudah merasakan manfaatnya secara langsung. Ada beberapa ibu yang sudah berhasil menjual barang melalui aplikasi Carousell.
“The Absolute Indifference of the Majority”: The Western Canadian Association of the Deaf and the Establishment of Deaf Education in Saskatchewan, 1923–1931
Authors: Barron Sandy
Published: February 2021

This article examines the role of the Western Canadian Association of the Deaf (wcad) in the establishment of the Saskatchewan School for the Deaf (ssd) from 1923–1931. Using correspondence between provincial officials, wcad figures, parents of deaf children, as well as extensive application records and contemporary deaf publications, it contributes to a growing body of historical literature that seeks to reappraise the political advocacy and agency of deaf and disabled people in Canada before the late twentieth century. This article argues that the wcad was instrumental in both forcing the government of Saskatchewan to meaningfully extend compulsory education to deaf children and youth, and in advising the governments of James Gardiner and J.T.M. Anderson on how best to establish an ssd that met many of the Association’s key cultural, linguistic, and educational demands.
Dramas and their perception: A Social Awareness of Drama's Structures and their Representation
Authors: Amin Salman , Fatima Saadia , Ali Sajjad
Published: February 2021

This research is designed to explore the impact of Pakistani dramas of the private channel on Pakistani women. To witness various effects caused by dramas, detailed research is carried out. To gather and document the perceptions of the female viewers of Rawalpindi and Islamabad, a detailed questionnaire was prepared. Through a sample of 300 respondents, data was collected from people of different age groups, educational background and occupational groups. The perceptions of viewers about the various content in dramas showed that private channels provide a lot of content for entertainment, education, comedy, information, serious, horror, emotional and musical content. Overall, it was observed that Geo TV dramas provide the content mentioned more frequently than Hum TV and ARY Digital. The study concludes that there are significant changes taking place in all the mentioned domains. The degree to which private channels display different lifestyles was another important variable of the study that has been discussed for so long, but it was observed from the finding that dramas of private channels promote multiple lifestyles (Western and Indian) on an equal basis.
Projection of CPEC in Print Media of Pakistan from 2014-2019
Authors: Haider Syed Imran , Waqar Azhar
Published: February 2021

The study aims to examine the narrative of CPEC disseminated by the Pakistani national print English media. For comprehensive understanding, the CPEC was divided into three dimensions, economic, culture and environment. The study follows the secondary data for the analysis of the narrative on the print English media about the CPEC. The English media was specified in a way that all the leading newspapers like Dawn, The Tribune and The News were consulted covering the news and the opinion-based articles. The study finds that the change in the trends about narrative of CPEC seems fluctuating between the favorable and unfavorable for Pakistan. Hence, the changing trends in narrative seem quite clear and visible. The study recommends that government and relevant officials representing CPEC should properly interaction with the media and journalists need to be capacitated in knowledge about the particular aspects of CPEC.
Influence of Facebook on Educational, Political and Cultural life of Students: A Case Study of University of Swat
Authors: Spogmai  , Ali Sajjad
Published: February 2021

This study was conducted to analyze the influence and exposure of university students on Facebook. The researcher conducted to examine the educational, political, cultural and fashion influence of Facebook on university students. A quantitative methodology was used by the researcher, and survey technique was used for the collection of data. A questionnaire was designed to contained close-ended questions to collect data randomly from the students of the University of Swat. The data was analyzed through the statistical package for social sciences (SPSS, version.19) to ensure impartiality in the results of the study. The results revealed that most of the students are using Facebook. The study also disclosed that students in the university of Swat are using Facebook for educational purposes. The researcher found that Most of the students also use Facebook for fashion and cultural information. The study proved that most of the students using Facebook for online educational information as compare to political information. It is also found that Students exposed to fashion information than cultural information through Facebook.
A Corpus Assisted Comparative Study of Metadiscourse Markers in Opinion Articles of American and Pakistani Newspapers
Authors: Rashid Athar , Ali Arshad , Abbas Shahid
Published: February 2021

Writers often use metadiscourse markers to express their messages compellingly and persuasively. The current research explores the frequency of metadiscourse markers in Pakistani and American Newspapers using corpus linguistics methods. Opinion articles from both The News and The USA Today were collected, cleaned, and analyzed using the AntConc software. The primary focus of the research was on two interpersonal features: hedges and boosters. The findings of the study suggest that American writers tend to use more metadiscourse markers than Pakistani writers do. The findings also suggest that the frequency of hedges is higher than that of boosters in both Pakistani and American articles. The findings also suggest that writers prefer to use hedges to convey doubt, uncertainty, and lack of confidence. On the other hand, writers prefer to use boosters when writing about facts that make their writing style more confident and assertive.
Rural Farmers’ Perceptions of the Adoption of Internet-Enabled Computer in the Eastern Cape, South Africa
Authors: Usadolo Sam Erevbenagie
Published: February 2021

ABSTRACT Unstructured interviews were used to examine the perceptions of farmers about internet-enabled computers using the five main attributes of innovation as an analytic lens. Findings show that internet-enabled computers have relative advantages over other means of obtaining information but rural farmers experience challenges with accessibility. The farmers’ sources of agricultural information are incompatible with their needs, suggesting the need for internet-enabled computers. However, the inability to use internet-enabled computers by the participants was cited as a disadvantage. The findings about trialability show that most of the agricultural information obtained through internet-enabled computers did not work when applied to the local context. Positive perceptions by rural farmers about the observability of the effects of the internet-enabled computers for agricultural information were apparent. The findings reflect opportunities and challenges about adoption of internet-enabled computers by poor rural farmers. Based on the analysed data further studies are suggested.
Biopelículas activas de extracto acuosos de Gliricidia sepium y su influencia en la vida útil microbiológica del queso costeño
Authors: González-Cuello Rafael , Guardo-Palomino Fidel , Quintana-Martínez Somaris
Published: February 2021

La elaboración de biopelículas con propiedades bioactivas es un área interesante en el campo de los empaques alimentarios. El objetivo de este estudio fue obtener biopelículas activas (BPA) a base de extracto acuoso de hojas de Gliricidia sepium y determinar su efecto en la vida útil microbiológica del queso costeño. Para la fabricación de las BPA, el extracto acuoso fue microencapsulado, mediante gelación iónica y, posteriormente, incorporado en las biopelículas. La determinación de la vida útil de muestras de queso costeño, se llevó a cabo mediante microbiología predictiva, utilizando el modelo de Monod Hinshelwood. Las microcápsulas utilizadas tuvieron un diámetro promedio de 273,786µm. Los resultados mostraron un aumento en la vida útil microbiológica de 26,7 días, en quesos con BPA, almacenado a 7°C, en comparación con una muestra control (sin BPA), confirmando que las BPA investigadas ejercen un efecto inhibitorio sobre los microorganismos, causantes de deterioro en quesos. Por tal motivo, la metodología aquí planteada puede ser una alternativa en la conservación de un producto perecedero, como el queso costeño.
ANALYSIS OF MARKETING STRATEGY FOR MOBILE VEGETABLE TRADERS IN SUKORAMBI DISTRICT JEMBER REGENCY
Authors: Sauqi Ahmad
Published: February 2021

In Sukorambi District, many of the people are engaged in the mobile vegetable trading business. The sampling technique uses a multistage sampling technique, the SWOT analysis method by determining the IFAS Matrix, EFAS. From the results of IFAS the strength and weakness factors have a total score of 2.95. Value> 2.5 indicates a strong internal potential. From this it can be judged that the internal potential of the mobile vegetable traders is strong. From the EFAS results, the opportunity and threat factors have a score of 3.59. Because the total score is close to 4.0, it means that this indicates that the mobile vegetable traders respond to the opportunities in an extraordinary way. SO strategy by maintaining the quality of the product being sold. ST strategy by providing the maximum possible service. WO strategy by starting the use of price tagging. WT strategy by improving the quality of packing.

Keywords:Strategy;Marketing; Traders; Vegetable Around.
Factors Affecting Cloves Production in Woewolo Village, Nagekeo District, East Nusa Tenggara Province, Indonesia
Authors: Dua Mea Maria Helena Carolinda
Published: February 2021

To plant cloves is very promising for the farmers in Woewolo. The cloves plantation in Woewolo Village, Mauponggo District is an effort to obtain added value for economic life.  the purpose of this study was to determine whether capital, labor, and land area affect the production income of clove farmers in Woewolo Village, Nagekeo Regency. This research is a type of quantitative research.  The population determined in this study were all clove farmers in Woewolo Village with 75 samples.  Primary data collection was carried out by distributing questionnaires to respondents. Based on the Multiple Linear Regression Test the Variables Capital (X1), Labor (X2), and Land Area (X3) have a positive regression coefficient direction on Clove Production in Woewolo Village, Mauponggo District.  The statistical test results prove that capital affects clove production as indicated by the acquisition of t-test results, namely the t-count value of 2.452 with a significance of 0.017 at the 5% significance level where 0.017 <0.05.  The results of statistical tests prove that labor affects clove production as indicated by the acquisition of t-test results, namely the t-count value of 2.489 with a significance of 0.015 at the 5% significance level where 0.015 <0.05.  The results of statistical tests prove that land area affects clove production as indicated by the acquisition of t-test results, namely the t-count value of 5.347 with a significance of 0.000 at the 5% significance level where 0.000 <0.05.  the percentage of the contribution of the influence of the independent variables including the capital, labor, and land area on the clove production variable is 35.8%.
Correlation of Radiation Dose and PSA Blood Level in the Radiotherapy of Prostate Cancer: A retrospective case series
Authors: Margaretha LT Ade , Gondhowiardjo Soehartati A.
Published: February 2021

Background: The objective of this study was to analyze the correlation of radiation dose and Prostate-Specific Antigen (PSA) blood level following radiation therapy in prostate cancer.Methods: The study population was serial of 13 patients with histologically proven T1b-T4, any N, M0 prostate adenocarcinoma, having any Gleason score with any PSA before and after complete EBRT (external beam radiotherapy), from January 2009 to December 2010 and evaluated for PSA decrease post-EBRT.Results: Out of 13 patients, one patient received 62 Gy, one patient received 72 Gy, and 11 patients received 80 Gy. PSA blood level was decreased (median 5.4, 9.43 and 25.27, respectively) in all patients.Conclusion: This case series results were consistent with the results of previous studies that a higher radiation dose will have a higher PSA decrease with a tolerable side effect.
Potential of Sriwijaya Thermal Cycler Smart Controlling-Based as a Tool for DNA Sequence Polymerase Chain Reaction
Authors: Adnindya Msy Rulan , Hidayat Rachmat , Indri Seta Septadina  , Muhammad Reagan
Published: February 2021

A B S T R A C TIntroduction. Along with the COVID-19 pandemic, the need for a thermal cyclerdevice for examining COVID-19 is getting bigger. Many laboratories have overusedthe use of thermal cyclers due to the limited availability of this tool. This study aimsto test the effectiveness of the Sriwijaya thermal cycler based on a smart controllerin conducting PCR DNA sequences. Methods. The research design was anexperimental study with a posttest control group approach, in order to see anoverview of the results of the polymerase chain reaction (PCR) in the form ofintermediate DNA bands using Sriwijaya Thermal Cycler compared to groups usingfactory-made Thermal cyclers. Results. The PCR results showed precise results fromthe image and band separation, and there was a clear separation of the bands onthe marker. The PCR results from the ACE I / D gene showed quite good and optimalresults in the separation of the PCR results band. Conclusion. Sriwijaya thermalcycler is effective in DNA polymerase chain reaction (PCR) sequences comparable tothat of the manufacturer's Thermal Cycler.
The Influence of Knowledge, Attitudes and Behavior of Cleaning Officers with the Number of Mosquito Larvae in the Water Reservoir Punti Kayu Palembang City
Authors: Aldi Alfian  , Anwar Chairil , Iche Andriyani Liberty
Published: February 2021

A B S T R A C TBackground Mosquito was one of the animals that can transmit deadly diseases.Information about water reservoirs as their habitat as well as human knowledge,attitudes and behavior factors are considered important to help eradicate mosquito.This study aims to determine the effect of knowledge, attitudes and behavior ofcleaners on the number of mosquito larvae in water reservoirs in Palembang.Methods This research was mixed method research (quantitative and qualitative) inthe field and laboratory. The research samples were all mosquito larvae andcontainers found. The research respondents were all cleaning services. Data werecollected by interviewing and filling in questionnaires, observing water reservoirsand identifying the types of mosquito larvae in microscope. Results A total of 40containers were found in Punti Kayu Nature Park. There were 8 containers that wereindoors (20%) and 32 containers were outdoors (80%) with 17 containers containedlarvae. Of all the containers that were positive for larvae, 6 were filled with clearwater and 11 were filled with turbid water. The number of larvae found were 358larvae outdoors and 82 larvae indoor with a total of 440 mosquito larvae with thegenus Culex spp. and Aedes albopictus species. The index of mosquito larvae wereobtained FLI (Free Larva index)=66,67%, HI (House Index)=33,33%, CI (ContainerIndex)=16,67%, BI (Breteau Index)=33.33% from the 3 buildings examined. Fromthese results, it was obtained DF (density figure) or density level of 5. There were 40containers that could be habitats for Culex spp. and Aedes albopictus. ConclusionThe knowledge, attitude and behavior of the cleaning services were good. Thenumber of mosquito larvae could be influenced by the frequency of cleaning and thelack of knowledge of the cleaning services.
Correlation of Vitamin D Serum Levels with Muscle Mass, Muscle Strength, and Physical Performance in the Elderly Community in Mohammad Hoesin General Hospital Palembang
Authors: Bachry Noveldy Calzoum , Nur Riviati  , Yulianto kusnadi  , Erial Bahar
Published: February 2021

A B S T R A C TIntroductionOlder people tend to have decreased activity and intake of macronutrients andmicronutrients that are not in accordance with the body's needs. Research in 2017on elderly men and women at the Center for Family Compensation (PUSAKA) inCentral Jakarta showed that 80.2% of elderly people have vitamin D deficiency. Lowserum levels of vitamin D in the body are the initial risk of decreased muscle massand physical performance in old age. where there is a significant correlation betweenlow serum vitamin D levels in the body with sarcopenia and mortality. The purposeof this study was to determine the correlation of vitamin D levels with muscle mass,muscle strength and physical performance in the elderly community at RSMHPalembang. Methods This research is a study analytic observation with a cross-sectional approach that was carried out at the Integrated Geriatric Clinic InternalMedicine RSMH Palembang from November 2019 to November 2020. A sample of 34people aged> 60 years were examined for muscle mass, muscle strength, physicalperformance and serum vitamin D levels. All processing and analysis The data inthis study used SPSS version 25 for Windows. Results From 34 subjects, it wasfound that there were 29 women (85.3%) and 5 men (14.7%). The mean value ofmuscle mass is38.76 ± 4.1 kg / m2, long runs within 6 meters 6.12± 0.9 m / sec,and hand grip strength 24.9 ± 5.2 kg. It was found that 18 (62.1%) female sampleshad vitamin D deficiency while 11 (37.9%) samples had vitamin D insufficiency.There was a significant correlation between muscle mass and hand grip strengthwith vitamin D with weak correlation strength and length of walking with vitamin Dwith moderate correlation strength.Conclusion There is a significant correlationbetween muscle mass and grip strength and walking time of 6 meters with vitaminD.
Methods of Selection and Maintenance of Experimental Animals for Biomedical Research
Authors: Hidayat Rachmat , Patricia Wulandari
Published: February 2021

A B S T R A C TResearch is an activity carried out based on scientific principles and methodssystematically to obtain information, data, and information from relatedsubjects, with understanding the theory and proving assumptions and / orhypotheses. The results obtained are conclusions that can be applied orbecome additional knowledge for the progress of science. However, researchactivities must still respect the rights and dignity of research subjects.Health research includes biomedical, epidemiological, social, and behavioralresearch. Some health research can be done in vitro, using mathematicalmodels, or computer simulations. If the research results are to be used forhumans, further research is needed using living materials (in vivo) such ascell lines and tissue cultures. However, to observe, study, and conclude alloccurrences in living things as a whole, experimental animals are neededbecause experimental animals have a value for each part of the body andthere are interactions between these body parts.
PREVALENCE OF THYROID DYSFUNCTION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Mali Manoj Kumar
Published: February 2021

Background: Patients with type 2 diabetes mellitus are more prone to thyroid disorders. Hypothyroidism in them leads to an aggravation of microvascular complications. Diabetic patients with hypothyroidism also are at an increased risk of cardiovascular disease. Screening for thyroid dysfunction in diabetic patients will allow early treatment of hypothyroidism.

Methods: All patients were evaluated for thyroid status; assessment of T3, T4 and TSH levels and Blood glucose levels and HbA1c.

Results: 22.00% patients were present with subclinical hypothyroidism, 18.00% patients were present with hypothyroidism and 4.00% patients present with hyperthyroidism

Conclusion: Screening for thyroid disease disease among patients with diabetes mellitus should be routinely performed for early detection and treatment of thyroid dysfunction to delay the complications of diabetes

Keywords: Thyroid, Type-2DM, Complication
APPLICATION OF APPENDICITIS INFLAMMATORY RESPONSE (AIR) SCORING SYSTEM FOR DIAGNOSIS OF ACUTE APPENDICITIS AND ITS COMPARISON WITH ALVARADO SCORE
Authors: Chouhan Ghaus Mohd , Sharma Mahesh Kumar
Published: February 2021

Background: The appendicitis inflammatory response (AIR) score is recently developed diagnostic tool that uses seven scored variables to stratify patients into low-, intermediate and high risk group.

Methods: The present study was conducted in the department of surgery. 100 patients presenting with pain in the right lower quadrant of abdomen, who after clinical examination were provisionally diagnosed to have acute appendicitis and warranted surgery for the same.

Results: AIR (98.00%) were more sensitive than Modified alverdo score (90.00%). Specificity (100%) and positive predict value (100%) were same in MAS & AIR.

Conclusion: To conclude, AIR scoring performed well almost equally with Alvarado system with high specificity and high negative predictive value preventing unnecessary negative appendectomies.

Keywords: AIR, MAS, Acute appendicitis
DIGITALISATION OF THE NATIONAL ECONOMY: ECONOMIC AND SOCIAL CONSEQUENCES
Authors:   University of State Fiscal Services of Ukraine, Pizhuk Olha , Muraviov Vasil ,   University of State Fiscal Services of Ukraine
Published: February 2021

The article examines the positive effects and negative consequences of the digital transformation of the national economy in terms of waves of technological progress and the spread of innovation. It is determined that the development of the digital economy is the most obvious result of the wave-like nature of digitalization. A three-sector model of the digital economy is proposed, where the primary sector is its core and includes fundamental innovations (semiconductors, microprocessors), basic technologies (computers, telecommunications devices), stimulating infrastructure (Internet and telecommunications networks); the secondary sector includes services based on basic digital technologies, including digital platforms, mobile applications, and electronic payment systems; tertiary – a digital economy based on a wide range of digital products and services, including e-commerce and new activities or business models that are transformed as a result of digital technologies. A system of indicators has been formed that provides a quantitative interpretation of the economic and social consequences of the process of the digital transformation of the national economy. Such an assessment will help to understand the potential impact of digital transformation on economic growth, which is often uneven, both within the country and between countries with different levels of socio-economic development. This impact was considered in several parameters, including labor productivity, gross domestic product, value-added, employment, as well as for various components of the digital economy. Emphasis is placed on the fact that the net impact on the overall economy is difficult to assess mainly due to the imperfection of existing methods of assessing the digital economy. It was found that the most threatening consequences of the digital transformation are labor displacement, as the exponential change in technology leads to the use of robots, autonomous vehicles, sensors, artificial intelligence, the Internet of Things, changing the workflow towards greater flexibility with the predominant use of temporary labor. The types of work organizations that are likely to be part of the working ecosystem for at least the next 10 years are described.
PROMOTION OF RURALTOURISM AS ONE OF THE PROMISING DIRECTIONS IN THE TOURISM SECTOR OF UKRAINE
Authors:   State Higher Educational Institution «Kherson State Agrarian University», Fesenko Anna
Published: February 2021

The goal of the work was to identify awareness-raising measures and prospects for the development of rural tourism in Ukraine. The following research methods are used to achieve this goal: historical - when studying the origins of the tourist industry in Ukraine; analysis and synthesis - in the study of the dynamics of tourism activities; abstract-logical - at generalization of theoretical, methodological and practical aspects of the problem being investigated. The article examines the current state of Rural Tourism and the tourism industry of Ukraine as a whole. A number of functions have been analysed and highlighted that the tourism industry performs in the national economy. The concept of rural tourism is based on a theoretical synthesis and rural areas, agro-tourism and ecotourism. It has been determined that all types of tourism can be developed in Ukraine but this potential is under-exploited and, as a consequence, the development of the tourism industry isn`t dynamic and doesn`t grow rapidly. Analyzing the current state of rural tourism in Ukraine, a number of disadvantages and advantages were identified. The prospects for the development of the tourism sector in Ukraine, including through the popularization of rural tourism, are revealed. Rural tourism is motivated by the desire to change load due to urban hypodynamy of the urban pace of life and desire for privacy and recreation in nature, the rejection of social constraints, introduction to the national characteristics of everyday life; use of environmentally friendly products in food, clothing, cosmetics. It is determined that in rural areas it is appropriate to jointly develop areas of ECO - and agro-tourism, based on the ever-increasing interest and need for environmentally friendly recreation areas and environmentally friendly products. During the study of this problem, a number of main components of rural tourism are identified and promising directions for the development of rural tourism are proposed. The practical significance lies in the fact that the proposed measures can be used in the development of regional strategies for rural development and during the popularization of rural tourism among the population of Ukraine and abroad.
Bioregione come spazio di ricerca e progetto
Authors: Dezio Catherine , Longo Antonio
Published: February 2021

Il servizio propone una riflessione sulla natura esplorativa e progettuale del termine ‘bioregione'. Il campo d'indagine è la metropoli milanese, centro di un sistema di luoghi e paesaggi, relazioni tra produzioni e consumi, gestione di scarti ed energia. La prospettiva bioregionale, spesso legata a nuove ideologie e scuole, affinché non risulti una semplice modalità di identificazione accademica, richiede approcci pragmatici basati su azioni concrete; qui si parla di azioni rivolte al miglioramento della qualità agronomica e ambientale e della relazione tra produzioni, consumi e scarti. La lettura territoriale e paesaggistica del sistema bioregionale si offre come una prospettiva di lavoro e di ricerca imperfetta, ma utile alla comprensione di relazioni complesse, che permette di affrontare sfide ambientali e paesaggistiche riguardanti i territori contemporanei, nella valorizzazione delle risorse locali.
Romano di Lombardia: i valori molteplici di un piccolo capoluogo
Authors: Alì Alessandro
Published: February 2021

Collocata in prossimità di vecchi e nuovi tracciati infrastrutturali della metropoli pedemontana nella Bassa Bergamasca, Romano di Lombardia trae la sua originalità dall'incrocio di diversi valori. È una città ricca di storia e arte, con una sedimentata tradizione civica; ha una popolazione dinamica e articolata che produce servizi e lavoro; è un contesto urbano compatto che ha conservato una forma ordinata, anche dopo differenti cicli edilizi di carattere espansivo; è una città d'acqua segnata dal fiume Serio e da un fitto reticolo idrico superficiale. Le fragilità economiche e sociali della sua popolazione e quelle territoriali conseguenti alla profonda crisi dell'edilizia non impediscono a Romano di Lombardia di giocare il ruolo di capoluogo supplente per un vasto territorio tra le province di Bergamo, Brescia e Cremona.
I servizi ecosistemici a supporto del processo di Vas
Authors: Arcari Silvia , Gemini Giuliana , Paruscio Valerio
Published: February 2021

Il contributo descrive un approccio metodologico basato sull'integrazione dei servizi ecosistemici a supporto del processo di pianificazione territoriale del Piano di governo del territorio (pgt) del Comune di Romano di Lombardia. Tale approccio si fonda sulla considerazione del ruolo di questi servizi in ogni fase del percorso di piano/valutazione ambientale strategica (vas), dallo scoping alla stima degli effetti, alla definizione di criteri attuativi. I servizi ecosistemici sono stati caratterizzati elaborando dati spaziali provenienti da banche dati pubbliche o costruendo mappe originali con la collaborazione dei cittadini. L'analisi dello stato dei servizi ecosistemici e la stima della variazione del grado di erogazione degli stessi a seguito dell'attuazione delle previsioni di piano hanno costituito il contributo della vas alla sostenibilità delle scelte di piano.
La costa metropolitana e la costruzione di una visione comune. Alcuni indizi dal caso Bari
Authors: Calace Francesca , Angelastro Carlo , Giovanna Paparusso Olga
Published: February 2021

Nei territori affacciati sul mare, peculiari sia in termini fisico-ambientali, sia per le dinamiche insediative, sia infine per le economie tradizionali ed emergenti, molteplici strumenti e attori intervengono, ciascuno con la propria razionalità, nel trasformarli. Quando poi tale condizione si esprime in una dimensione metropolitana, la maggiore intensità dei fenomeni ambientali e insediativi e la concentrazione di interessi e attori rendono il territorio costiero particolarmente soggetto a pressioni. Campo di riflessione è la costa della città metropolitana di Bari, nella quale questo patchwork necessita di essere indagato, in una prospettiva interscalare e non gerarchica, per verificare se possa essere rintracciato un progetto comune e quali ne possano essere i capisaldi.