bluuebunny/crossref_metadata_2025 huggingface dataset:
Validity and Reliability of Quality of Nursing Work Life Instrument for Hospital Nurses
Authors: Utami Utami , Kusnanto Hari , Riyono Bagus , Alim Syahirul
Published: June 2019

Introduction: The validity and reliability of the quality of nursing work life (QNWL) instrument in hospitals that suitable to treatment needs include: trust, care, respect, learn, and contribute need, have to be assessed. Therefore, in order to perform good care, it is necessary to notice QNWL aspect, which the implementation may be assessed by using valid and reliable instruments. This study aimed to evaluate the construct validity of the QNWL scale in hospital.Methods:  The research used a cross-sectional approach and the respondents were 100 experts in nursing and 400 nurses working in four hospitals in Gresik, Indonesia, who have been working for minimum one year. The sampling technique was purposive sampling. We analyzed the data using content analysis, the validity of item discrimination using Pearson products moment, reliability with Cronbach’s alpha, and construct validity with Confirmatory Factor Analysis.Results: The results based on content validity index QNWL instrument was 0.2075-0.915, with an average 0.7059 (high). Item discrimination capacity was 0.339-0.79 (high), while the reliability was 0.9374 (very high) and the validity of the construct meets the goodness of fit criteria.Conclusion: All constructs are able to explain and support the QNWL instrument model. This research can be used to measure the quality of work life of nurses in all classes of hospitals in Indonesia.
Factors Associated with Nurses’ Self-Efficacy in Applying Palliative Care in Intensive Care Unit
Authors: Kurnia Theresia Avila , Trisyani Yanny , Prawesti Ayu
Published: June 2019

Introduction: The increasing need for palliative care (PC) in the intensive care unit (ICU) is characterised by an increasing number of patients with critical and terminals conditions. It requires comprehensive treatment of nurses, through PC. Self-efficacy is a major predictor that affects the application of PC in ICU. Therefore, nurses need to have high self-efficacy to provide quality PC for patients and their families. This study aimed to analyse the factors that dominant relates to nurses' self-efficacy in implementing of providing PC in ICU.Methods: This research was correlational research with cross-sectional survey design. The sampling technique used was total sampling, which involved 127 critical nurses who were actively working at a general hospital in Bandung, Indonesia. Data were collected using questionnaires. Bivariate analysis using Pearson correlation and Rank-Spearman test and multivariate analysis using linear regression.Results: The results showed that the majority of respondents had high self-efficacy, working experience >15 years, enough interest to the nursing profession had less knowledge and negative perception related to the PC in ICU. There was a significant relationship between self-efficacy with work experience, nurses' interest in the nursing profession, knowledge and perception variables. The most dominant factors related to self-efficacy, namely knowledge and perceptions of nurses related to PC.Conclusion: This study indicates that majority of the respondents lacked knowledge and had negative perceptions related to PC in ICU, it is necessary to socialise and training related to it by focusing on self-belief or self-efficacy of nurses on their ability.
ÜNİVERSİTE ÖĞRENCİLERİNİN FİNANSAL OKURYAZARLIK DÜZEYLERİNİN ANALİZİ: BANKACILIK ve FİNANS BÖLÜMÜ ÖĞRENCİLERİ ÜZERİNE BİR UYGULAMA - ANALYSIS OF THE FINANCIAL LITERACY LEVELS OF UNIVERSITY STUDENTS: AN APPLICATION ON DEPARTMENT OF BANKING AND FINANCE
Authors: KAYA Murat , GÜNEŞ Hidayet
Published: June 2019

Bireylerin kazanmış oldukları gelirlerini, doğru ve etkin bir şekilde değerlendirebilmeleri; bunları yatırım araçlarına kanalize ederken bilinçli olarak karar verebilmeleri, finansal konularda bilgi birikiminin yeterli düzeyde olması ile mümkündür. Finansal açıdan gerekli olan bilgi düzeyinin ölçülmesi ve finansal farkındalığı esas alan finansal okuryazarlık; bireye, kurumlara ve esasında ülke ekonomisine yapacağı katkılar dikkate alındığında ön plana çıkmaktadır. Bu çalışmada kendilerini geliştirebilme imkânı yüksek olan üniversite öğrencilerinin finansal okuryazarlık seviyeleri tespit edilmeye çalışılmıştır. Bu kapsamda Mehmet Akif Ersoy Üniversitesi İİBF’de eğitim gören Bankacılık ve Finans Bölümü öğrencilerine anket çalışması yapılmıştır. Analiz sonuçlarına göre, öğrencilerin finansal okuryazarlık seviyeleri; yüksek % 6,5, orta % 47,3, düşük % 37,2, çok düşük % 9 olarak belirlenmiştir. Ayrıca finansal okuryazarlık seviyelerinin cinsiyet, öğretim türü, sınıf, kredi kartı kullanımı, internet bankacılığı kullanımı ve döviz alım satım işlemi yapılması ile istatistiki olarak anlamlı bir şekilde farklılaştığı tespit edilmiştir.
2000 SONRASI YAŞANAN FİNANSAL KRİZLERİN TÜRKİYE'NİN DIŞ TİCARETİ ÜZERİNE ETKİLERİ - THE EFFECTS OF FINANCIAL CRISES AFTER 2000 ON TURKEY'S FOREIGN TRADE
Authors: UÇAR Çiğdem , HATIRLI Selim Adem , ÖNDER Kübra
Published: June 2019

Türkiye, 2000 yılı ve sonrası; Kasım 2000, Şubat 2001 ve 2008 olmak üzere üç büyük kriz yaşamıştır. 2000 ve sonrası yaşanan krizlerin etkilediği ekonomik aktörlerden biri de dış ticarettir. Dış ticaret, özellikle gelişmekte olan ülkelerin ekonomik hacmini etkileyen en önemli unsurlardan biridir. Dış ticaretin ekonomi üzerindeki öneminden dolayı bu çalışmada, Türkiye’nin 2000 ve sonrası yaşamış olduğu krizlerin dış ticaret üzerindeki etkisinin analizi amaçlanmıştır. Çalışmanın amacı doğrultusunda; ihracat ve ithalat denklemlerinin kurulabilmesi için reel efektif döviz kuru, büyüme ve Türkiye’nin ihracatta yoğun olduğu 6 ülkenin milli gelir değerleri analize dahil edilmiştir. Analizde, 2000-2017 dönemlerine ait aylık zaman serileri kullanılmıştır. Analizde ilk olarak zaman serisi verilerinin durağan olup olamadıkları analiz edilmiş ve birim kök analizi sonucunda aynı derecede bütünleşik oldukları tespit edilen verilerin uzun dönem ilişkileri Johansen Eşbütünleşme analizi çerçevesinde tahmin edilmiştir. Ayrıca, ithalat ve ihracat denklemleri için zayıf dışsal olmayan değişkenler kullanılarak uzun dönem denge değerine doğru yakınlaşma hızları ise Hata Düzeltme Modeli (VECM) kullanılarak analiz edilmiştir. Analizde; ihracat ve ithalatın yaşanan bir şok karşısında uzun dönemde tekrar dengeye geldiği ve dengeye gelme süresinin; ihracatta yaklaşık 34 dönem (34 ayda) ve ithalatta ise 142 dönem (142 ay) sürdüğü sonucuna ulaşılmıştır.
ULUSLARARASI AKTÖRLERİN KÜRESEL SAĞLIK POLİTİKALARI ÜZERİNE ETKİLERİ: TEORİK BİR İNCELEME - THE EFFECTS OF INTERNATIONAL ACTORS ON GLOBAL HEALTH POLITICS: A THEORETICAL REVIEW
Authors: EKE Erdal , EROYMAK Selin
Published: June 2019

Özellikle 1980’li yıllardan günümüze kadarki dönemde, küreselleşme olgusunun da etkisiyle küresel sağlık politikaları ve uygulamalarında ciddi bir değişim ve dönüşüm gerçekleşmiştir. Bu çalışmanın amacı DSÖ, DB ve IMF gibi uluslararası aktörlerin küresel sağlık politikaları ve uygulamaları üzerindeki etkisini betimlemektir. Çalışma kapsamında sağlık politikaları açısından DSÖ’nün günümüze kadarki yaklaşım tarzı kronolojik bir bağlamda ele alınmış, ayrıca DB ve IMF’nin sağlık politikalarına yönelik faaliyetleri hakkında da bir betimleme yapılmaya çalışılmıştır. Çalışma ile DSÖ, DB ve IMF’nin sağlık politikalarının şekillenmesi ve uygulanması açısından ciddi bir etkiye sahip oldukları ve politikaların özündeki düşüncenin zamana göre değiştiği başta olmak üzere çok sayıda sonuca ulaşılmıştır.
Isolation and Culture of Skin-Derived Differentiated and Stem-Like Cells Obtained from the Arabian Camel (Camelus dromedarius)
Authors: Saadeldin Islam , Swelum Ayman , Noreldin Ahmed , Tukur Hammed , Abdelazim Aaser , Abomughaid Mosleh , Alowaimer Abdullah
Published: June 2019

Elite camels often suffer from massive injuries. Thus, there is a pivotal need for a cheap and readily available regenerative medicine source. We isolated novel stem-like cells from camel skin and investigated their multipotency and resistance against various stresses. Skin samples were isolated from ears of five camels. Fibroblasts, keratinocytes, and spheroid progenitors were extracted. After separation of different cell lines by trypsinization, all cell lines were exposed to heat shock. Then, fibroblasts and dermal cyst-forming cells were examined under cryopreservation. Dermal cyst-forming cells were evaluated for resistance against osmotic pressure. The results revealed that resistance periods against trypsin were 1.5, 4, and 7 minutes for fibroblasts, keratinocytes, and spheroid progenitors, respectively. Furthermore, complete recovery of different cell lines after heat shock along with the differentiation of spheroid progenitors into neurons was observed. Fibroblasts and spheroid progenitors retained cell proliferation after cryopreservation. Dermal cyst-forming cells regained their normal structure after collapsing by osmotic pressure. The spheroid progenitors incubated in the adipogenic, osteogenic, and neurogenic media differentiated into the adipocytes, osteoblasts, and neurons, respectively. To the best of our knowledge, we isolated different unique cellular differons and stem-like cells from the camel skin and examined their multipotency for the first time.
Comparing f-OFDM and OFDM Performance for MIMO Systems Considering a 5G Scenario
Authors: Pereira de Figueiredo Felipe Augusto , Aniceto Nathália F. T. , Seki Jorge , Moerman Ingrid , Fraidenraich Gustavo
Published: June 2019

The advances mobile communications has seen in recent years has rendered the radio spectrum a limited and, hence, an expensive resource. Therefore, technologies that support unlicensed access to spectrum are needed. Therefore, the adoption of novel modulation schemes becomes of utmost importance to obtain better spectral-localization and reduce the OOBE (\textit{Out of Band Emission}) inherent to OFDM (\textit{Orthogonal Frequency Division Multiplexing}) and, consequently, mitigating the interference between secondary (\textit{unlicensed}) and primary users. In this scenario, we assess the gain in the bit error probability using f-OFDM (\textit{filtered-OFDM}) in MIMO systems, both used in the 5G RANGE project.
PENGARUH PELATIHAN AKUNTANSI SYARIAH, SISTEM INFORMASI AKUNTANSI DAN PENGENDALIAN INTERNAL TERHADAP KINERJA KARYAWAN BMT KABUPATEN KUDUS
Authors: Husnurrosyidah Husnurrosyidah
Published: June 2019

BMT is a sharia microfinance institution that can reach all levels of society and has the potential to develop into a professional, healthy, and sharia Islamic microfinance institution. However, based on observations in several BMTs domiciled in Kudus, Pati, Jepara and Rembang areas, it still seems that employee performance is poorly demonstrated by marketing that cannot reach the targets set by BMT, even many fictitious sales agents are very detrimental to BMT. This is due to the low internal control in the BMT. In addition, there are still many BMT employees who are professional with accounting so employees need sharia accounting training. This research is a field research with a quantitative approach. The data used are primary and secondary data with survey methods through questionnaires. There are three independent variables in this study, namely (X1) training in Islamic accounting, (X2) accounting information systems, and (X3) internal control. The dependent variable (Y) in this study is employee performance. A sample of 94 respondents, using the purposive sampling method. The results of this study indicate that: 1) sharia accounting training has an effect on employee performance indicated that the PAS direct effect coefficient on KK (path c) in model (1) is 0.12 and significant (<0.02); 2) accounting information system influences employee performance by 0.19; 3) internal control has an effect on employee performance indicated by direct effect coefficient of 0.35.
Targeting Youth to Prevent Later Substance Use Disorder: An Underutilized Response to the US Opioid Crisis
Authors: Compton Wilson M. , Jones Christopher M. , Baldwin Grant T. , Harding Frances M. , Blanco Carlos , Wargo Eric M.
Published: June 2019

The evolving US opioid crisis is complex and requires myriad different interventions. These include reducing opioid overprescribing and curtailing the supply of illicit opioids, overdose rescue interventions, and treatment and recovery support services for those with opioid use disorders.

To date, more distal primary prevention strategies that have an evidence base are underutilized. Yet, the impact of early environments on later substance use disorder risk is increasingly well understood, including knowledge of the mechanistic linkages between brain development and subsequent risk behaviors. Applying this developmental framework to prevention shows promise, and some middle-school interventions have demonstrated significant reductions in prescription opioid misuse.

Reducing these risks of initial misuse of opioids may be the “ounce of prevention” that makes a substantial difference in a society now reeling from the worst drug crisis our country has seen. The challenge is to continue to develop and test promising distal interventions and to support implementation fidelity through frameworks that ensure their cultural appropriateness and sustainability. In addition, research is needed to develop new prevention strategies for adults, including patients with pain at risk for transitioning from prescription to illicit opioids.
Social Marketing of Mental Health Treatment: California’s Mental Illness Stigma Reduction Campaign
Authors: Collins Rebecca L. , Wong Eunice C. , Breslau Joshua , Burnam M. Audrey , Cefalu Matthew , Roth Elizabeth
Published: June 2019

Objectives. To understand the processes involved in effective social marketing of mental health treatment.

Methods. California adults experiencing symptoms of probable mental illness were surveyed in 2014 and 2016 during a major stigma reduction campaign (n = 1954). Cross-sectional associations of campaign exposure with stigma, treatment overall, and 2 stages of treatment seeking (perceiving a need for treatment and use conditional on perceiving a need) were examined in covariate-adjusted multivariable regression models.

Results. Campaign exposure predicted treatment use overall (odds ratio [OR] = 1.82; 95% confidence interval [CI] = 1.17, 2.83). Exposure was associated with perceived need for services (OR = 1.64; 95% CI = 1.09, 2.47) but was not significantly associated with treatment use in models conditioned on perceiving a need (OR = 1.52; 95% CI = 0.78, 2.96). Exposure was associated with less stigma, but adjustment for stigma did not affect associations between exposure and either perceived need or treatment use.

Conclusions. The California campaign appears to have increased service use by leading more individuals to interpret symptoms of distress as indicating a need for treatment. Social marketing has potential for addressing underuse of mental health services and may benefit from an increased focus on perceived need.
Case report:Intravitreal Conbercept for treatment of choroidal neovascularisation secondary to choriodal osteoma
Authors: M  , y
Published: June 2019

Background: Choriodal osteoma is a rare condition. Although anti-VEGF treatment has been reported to be effective in managing choroidal neovascularisation secondary to choriodal osteoma, to the best of our knowledge, this is the first report of using conbercept in such condition.
Case presentation:This report describes a case of choroidal neovascularisation secondary to choriodal osteoma. A 37-year old female presented with decreased vision and distortion in left eye. Fundus image revealed an orange-yellow lesion with clear boundary in the macular area. Fluorescein angiography indicated choroidal neovascularization(CNV). OCT, B-scan and CT scan showed features of choroidal osteoma. Intravitreal Conbercept was given for four times over a period of 10 months, resulting stability of visual acuity and regression of CNV.
Conclusions:Intravitreal Conbercept can be an effective modality in short term in controlling choroidal neovascularisation secondary to choriodal osteoma.
Manual Therapy Versus Therapeutic Exercise in non-specific chronic neck pain: study protocol for a randomized controlled trial.
Authors: Bernal-Utrera Carlos , Gonzalez-Gerez Juan Jose , Saavedra-Hernandez Manuel , Lerida-Ortega Miguel Angel , Rodriguez-Blanco Cleofas
Published: June 2019

• Background: Underlying mechanisms of non-specific chronic neck pain relapses are not clear, but it could be associated with a deficit and alteration of neck muscles propioception that play a decisive role in cervical joint position, motor control of the head and postural stability. Numerous treatments for non-specific chronic neck pain have been described in the scientific literature. However, few studies analyze its influence on postural stability, since these alterations are not fully described, and various theories emerge about the reasons that cause it. Our mainly aim is analyze the differences in postural stability, pain, cervical disability and the relation between them produced by a treatment based on manual therapy and other based on therapeutic exercise.
• Methods: The short-term and mid-term changes produced by different therapies on subjects with non-specific chronic neck pain will be studied. The sample will be randomly divided into three groups, manual therapy, therapeutic exercise and placebo. As dependent variables of the study, we will take: a) overall balance index, measured through a dynamic stabilometric platform; b) pain, based on the visual analog scale and the pressure pain threshold; c) cervical disability, through the cervical disability index. The findings will be analyzed statistically considering a 5% significance level (p ≤ 0.05)
• Discussion: Our study aims to provide knowledge about postural stability and its relationship with pain in subjects with non-specific chronic neck pain. Analyzing the results produced by different types of therapy will allow us to draw conclusions about the mechanisms that may elicit these alterations, structural or central mechanisms.
• Trial registration: Brazilian Clinical Trial Registry, RBR-2vj7sw. Registered on 28 November 2018.
Objective Optical Quality in Eyes with Customized Selection of Aspheric Intraocular Lens Implantation
Authors: Tan Qing-Qing , Lin Jia , Tian Jing , Liao Xuan , Lan Chang-Jun
Published: June 2019

Backgroud

To compare the postoperative optical quality in eyes with customized selection and random selection of aspheric intraocular lens (IOL) implantation.

Methods

A prospective, nonrandomized study was implemented in adult cataract patients who underwent unilateral phacoemulsification with aspheric IOL implantation. Patients were allocated into two treatment groups: a customized group and a control group. In the customized group, the aspheric IOL selection was based on the corneal spherical aberration to enable the postoperative target ocular spherical aberration closest to zero; in the control group, the aspheric IOLs were chosen using a random strategy. Primary outcome measurements included the following objective optical quality assessments: higher-order aberrations obtained by a Hartmann-shack aberrometer at 4mm and 6mm pupil diameters; objective scatter index (OSI), modulation transfer function (MTF) cut-off, Strehl ratio (SR) and a simulated contrast visual acuity—optical quality analysis system value (OV) obtained by a double-pass system with a 4-mm aperture. Subjective visual acuity was measured as secondary outcome. All the patients were followed up for 3 months.

Results

Eighty-four patients in the customized group and 78 patients in the control group were evaluated. There was no significant difference in postoperative visual acuity between the two groups (P>0.05). Significantly less ocular higher-order aberrations were shown in the customized group (P<0.05). No significant difference was shown in OSI, MTF cut-off, SR and OV between the two groups (P>0.05).

Conclusions

Although customized selection of aspheric IOL implantation showed less postoperative ocular aberrations, it performed similarly to random selection of aspheric IOL implantation in terms of postoperative visual acuity, simulated contrast visual acuity, intraocular scatter, modulation transfer function and Strehl ratio.
Prevalencia y factores asociados a sintomatología depresiva y ansiedad rasgo en estudiantes universitarios del área de la salud
Authors: Caro Yuri , Trujillo Sandra , Trujillo Natalia
Published: June 2019

Los estudiantes universitarios del área de la salud describen una mayor prevalencia de sintomatología depresiva y ansiosa asociada a fallas en su rendimiento académico. La comprensión de esta relación es crucial para la implementación de intervenciones en salud mental. Este trabajo pretende determinar la prevalencia de sintomatología depresiva y ansiedad rasgo y su relación con factores demográficos y asociados con el desempeño académico en estudiantes de pregrado. Se realizó un estudio transversal en 325 estudiantes de medicina de la universidad de Antioquia. De la población estudiada el 30,15% presentó algún síntoma de depresión, mientras que el 26,5% describió alta ansiedad. Los modelos de regresión sugieren que variables académicas como sentir angustia ante una actividad evaluativa, dificultades en la relación con sus compañeros y sentirse decaído explican la presencia de los síntomas/rasgos. Se sugiere implementar estrategias institucionales para mitigar estos síntomas y fortalecer el apoyo psicopedagógico.
Diseño de un software para estimulación del componente socio-emocional en niños con trastorno del espectro autista
Authors: Suárez-Pico Paola , Bonelo-Cuellar Gynna , Utria Oscar
Published: June 2019

Los trastornos del espectro autista se caracterizan por la presencia de limitaciones en la reciprocidad emocional e interacción social. En esta investigación se diseñó y validó por contenido un software para la estimulación de habilidades de comprensión emocional y social en niños con trastorno del espectro autista de alto nivel de funcionamiento. El software está conformado por tres dimensiones: reconocimiento emocional, comprensión emocional y comprensión de creencias; cada dimensión cuenta con niveles de complejidad baja, media y alta. La investigación se desarrolló bajo un diseño instrumental de corte psicométrico donde las unidades de análisis fueron las actividades validadas por 9 jueces, 8 de ellos expertos en neuropsicología e intervención en autismo y un juez experto en ingeniería y desarrollo de software. Los datos fueron analizados mediante la fórmula de coeficiente de razón de validez de contenido y los resultados muestran que se valida sin modificaciones el 99.06% de los ítems; el 0.4% de los ítems se conservan con modificaciones. Se concluye  que el software cuenta con un contenido válido para la estimulación del componente social y emocional en niños con trastorno del espectro autista de alto funcionamiento.
Incidencia del juego de la rayuela en el desarrollo de la psicomotricidad
Authors: Mendieta Lenin
Published: June 2019

La psicomotricidad es la disciplina que estudia el movimiento del sujeto y su relación con el desarrollo cognitivo, el objetivo del estudio fue determinar la incidencia de la práctica del juego de la rayuela en el desarrollo de la psicomotricidad en niños de 4 a 5 años. Fue un estudio controlado aleatorizado, en donde luego de seleccionar por criterios de inclusión y exclusión en niños del Jardín Parvulitos de Minerva, 12 niños fueron del grupo control y 12 del grupo entreno, tuvo una duración de 12 semanas, se valoró mediante una ficha de observación, diseñada según los objetivos del ministerio de educación del Ecuador para el ámbito de expresión corporal y motricidad para ese grupo etario con parámetros de: Adquirido, En proceso e Iniciado. Los resultados en las diferentes pruebas permitieron concluir que existe incidencia en la psicomotricidad, con la aplicación del juego de la rayuela.
How broadly do product preannouncement performance effects generalize? Product life cycle and switching cost perspectives
Authors: P. Mishra Debi
Published: June 2019

Firms use preannouncements to inform customers about the impending introduction of a new product or service. These preannouncements are significant events because they provide customers with product specific information while signaling the health, strategic intent, and future of a company. One important area of research in this field investigates the performance consequences of product preannouncements (PPA). However, a notable gap in our knowledge exists, because the focus of past research has been on studying wealth effects rather narrowly in certain industries, e.g., high-tech, or under certain contingencies. This restrictive approach is surprising, because PPA are observed in a broad range of product categories. Moreover, product life cycle and consumer switching cost theories predict performance effects of PPA irrespective of category or context. The author addresses this lack of generalizability by using switching cost and life cycle theories to hypothesize positive performance effects of PPA independent of context and contingencies. The event study method from finance is used to empirically test the relationship between PPA and stock prices in a broad sample of events comprising multiple product categories. Using events reported in the Wall Street Journal, evidence of a positive effect of PPA on stock prices irrespective of the type of product or context involved is found. Several managerial implications of the study are noted and avenues for further research are outlined.
Effect of Transport and Storage on the Weight and Moisture Loss of Exotic Fruits
Authors: Величко Надежда , Velichko Nadezhda , Рыгалова Елизавета , Rygalova Elizaveta , Шароглазова Лидия , Sharoglazova Lidia , Сутугина Ксения , Sutugina Ksenia
Published: June 2019

Every year, hundreds of thousands of tons of fruits and vegetables are supplied to the territory of the Russian Federation by exporting producers from different countries. During transportation and storage, the supplied fruits and vegetables undergo various physical and biochemical changes, leading to weight loss and changes in quality indicators. Loss of moisture during transportation is one of the main causes of damage to fruits and vegetables. The relevance of the research topic is determined by the need to minimize the loss of mass and moisture of exotic fruits during transportation and storage in warehouse conditions.Objective: to establish the rates of loss of 10 samples of exotic fruits. The samples included Thai pineapple, Thai watermelon, guava, cantaloupe melon, carambola, Thai mango, papaya of Holland variety, green papaya, passionflower (passion fruit, pitaya). The fruits were transported by air from Thailand (Bangkok) to Krasnoyarsk. The flight duration was 8 hours, flight altitude – 10,000 m. The storage conditions were as follows: temperature – 5–8°C, humidity – 47%, storage time – 10 days in winter period. The paper presents the results obtained for the dynamics of mass and humidity during transportation by air of samples of exotic fruits and during storage in warehouse conditions. It was established that the loss of mass and moisture of exotic fruits in the process of transportation and storage occurred in all samples. The highest percentage of weight loss was observed in Thai mango and amounted to 2.93%. The greatest loss of moisture during storage in warehouses was observed in Thai watermelon (3.5%), the smallest – in Thai pineapple (0.5%). The largest weight loss was set for guava (4.6%), the smallest – for Thai watermelon (0.5%).
Efficacy of integrated ultraviolet ultrasonic technologies in the removal of erythromycin- and quinolone-resistant Escherichia coli from domestic wastewater through a laboratory-based experiment
Authors: Annisha Owassa Dza Rebecca , Li Zifu , Zhou Xiaoqin , Stenay Junior Ngomah Madgil Don , Donde Oscar Omondi
Published: June 2019

Bacterial resistance to antibiotics has become a common occurrence especially in areas where antibiotic drugs are widely used. Moreover, the potential effect of antibiotic pollution and the presence of antibiotic-resistant genes (ARGs) on the composition of bacterial communities in the ecosystems continue to degrade the quality of most ecosystems. Despite the use of ultraviolet (UV) radiation and ultrasound (US) technologies in wastewater purification, little is known on their application in the elimination of fecal pathogenic microorganisms such as Escherichia coli. Moreover, their individual and combined potential in the elimination of erythromycin- and quinolone-resistant E. coli is a topic that still requires proper understanding. Therefore, this study was aimed at evaluating the individual and combined/integrative potential of UV radiation and ultrasonic technologies in the removal of erythromycin- and quinolone-resistant E. coli from domestic effluents using a laboratory experimental-based set-up. The results showed that UV radiation experiment was able to significantly eliminate erythromycin- and quinolone-resistant E. coli from the water to a value of 2 log units. Additionally, US technology was equally able to significantly reduce both the erythromycin- and quinolone-resistant E. coli to 2 log units. However, on combining the two technologies, there was further reduction to 1 log unit, hence, pointing to the need for adopting the integrative approach in water purification for increased wastewater purification efficiencies and improved ecosystem and human health.
Nanogels for Skin Cancer Therapy via Transdermal Delivery: Current Designs
Authors: Tran Phuong H.L. , Duan Wei , Lee Beom-Jin , Tran Thao T.D.
Published: June 2019

Background:

Recently, several strategies have been proposed for skin cancer therapy by transdermal
delivery, and particularly the use of nanotechnology.

Methods:

This process disrupts the stratum corneum to deliver a drug through the skin, allowing it to accumulate at
the tumor site.

Results:

Nanogels are drug delivery systems that can be applied to many diseases. Nanogel engineering has been
widely studied for use in drug delivery, particularly in cancer theranostics. This review summarizes specific strategies
for using nanogels to treat skin cancer, a topic that is limited in recent literature.

Conclusion:

Advanced techniques for effective skin cancer therapy based on the nanogel’s penetration and cellular
uptake abilities will be discussed. Moreover, techniques for penetrating the skin, as well as drug release, permeation
studies, and microscopic observations, will also be discussed.
Genetic Diversity Among Saudi Peganum harmala and Rhazya stricta Populations Using Chemical and ISSR Markers
Authors: Abd-Elgawad Magda E. , Alotaibi Modhi O.
Published: June 2019

Background:

The vernacular name 'Harmal' is used for two plant species in Saudi Arabia, i.e. Peganum harmala L. and Rhazya stricta Decne. Both are important medicinal plants which offer interesting pharmacological properties.

Objective:

This study aimed to evaluate the genetic diversity among different populations of harmal based on chemical variations of alkaloids and molecular polymorphism.

Methods:

Total alkaloids were extracted from plants of three populations of each species and estimated by using spectrophotometer and the chemical compounds were analyzed by Gas chromatography mass spectrometry (GC-MS). Molecular polymorphism was estimated by using the Inter Simple Sequence Repeat (ISSR) fingerprints.

Results:

The results showed that the alkaloids content of R. stricta was higher than P. harmala populations. The GC-MS analysis revealed the presence of (65-53) compounds in R. stricta and P. harmala, and the percentage of polymorphism was found to be 93.2%. Sixteen ISSR primers produced 170 scorable bands with an average of 9.6 bands per primer and 75%-100% polymorphism. The cluster analysis using the unweighted pair-group method of the arithmetic average (UPGMA) method based on combined data of GC-MS and ISSR markers divided the six harmal genotypes into two major groups.

Conclusion:

The existence of variations in chemical and genetic markers is useful for the selection of potential genotypes for medicinal use, and for breeding lines for medicinal substances production to spare wild plants from uncontrolled harvesting for folk medicine.
Anti-Inflammatory Effects of Novel Standardized Platelet Rich Plasma Releasates on Knee Osteoarthritic Chondrocytes and Cartilage in vitro
Authors: Gato-Calvo Lucía , Hermida-Gómez Tamara , Romero Cristina R. , Burguera Elena F. , Blanco Francisco J.
Published: June 2019

Background:

Platelet Rich Plasma (PRP) has recently emerged as a potential treatment for
osteoarthritis (OA), but composition heterogeneity hampers comparison among studies, with the result
that definite conclusions on its efficacy have not been reached.

Objective:

1) To develop a novel methodology to prepare a series of standardized PRP releasates
(PRP-Rs) with known absolute platelet concentrations, and 2) To evaluate the influence of this standardization
parameter on the anti-inflammatory properties of these PRP-Rs in an in vitro and an ex vivo
model of OA.

Methods:

A series of PRPs was prepared using the absolute platelet concentration as the standardization
parameter. Doses of platelets ranged from 0% (platelet poor plasma, PPP) to 1.5·105 platelets/µl.
PRPs were then activated with CaCl2 to obtain releasates (PRP-R). Chondrocytes were stimulated with
10% of each PRP-R in serum-free culture medium for 72 h to assess proliferation and viability. Cells
were co-stimulated with interleukin (IL)-1β (5 ng/ml) and 10% of each PRP-R for 48 h to determine
the effects on gene expression, secretion and intra-cellular content of common markers associated with
inflammation, catabolism and oxidative stress in OA. OA cartilage explants were co-stimulated with
IL-1β (5 ng/ml) and 10% of either PRP-R with 0.75·105 platelets/µl or PRP-R with 1.5·105 platelets/µl
for 21 days to assess matrix inflammatory degradation.

Results:

Chondrocyte viability was not affected, and proliferation was dose-dependently increased.
The gene expression of all pro-inflammatory mediators was significantly and dose-independently reduced,
except for that of IL-1β and IL-8. Immunoblotting corroborated this effect for inducible NO
synthase (NOS2). Secreted matrix metalloproteinase-13 (MMP-13) was reduced to almost basal levels
by the PRP-R from PPP. Increasing platelet dosage led to progressive loss to this anti-catabolic ability.
Safranin O and toluidine blue stains supported the beneficial effect of low platelet dosage on cartilage
matrix preservation.

Conclusion:

We have developed a methodology to prepare PRP releasates using the absolute platelet
concentration as the standardization parameter. Using this approach, the composition of the resulting
PRP derived product is independent of the donor initial basal platelet count, thereby allowing the
evaluation of its effects objectively and reproducibly. In our OA models, PRP-Rs showed antiinflammatory,
anti-oxidant and anti-catabolic properties. Platelet enrichment could favor chondrocyte
proliferation but is not necessary for the above effects and could even be counter-productive.
Cationic Antimicrobial Peptides for Tuberculosis: A Mini-Review
Authors: Silva Sara , Vale Nuno
Published: June 2019

Cationic antimicrobial peptides (CAMPs) can be considered as new potential therapeutic agents for Tuberculosis treatment with a specific amino acid sequence. New studies can be developed in the future to improve the pharmacological properties of CAMPs and also understand possible resistance mechanisms. This review discusses the principal properties of natural and/or synthetic CAMPs, and how these new peptides have a significant specificity for Mycobacterium tuberculosis. Also, we propose some alternative strategies to enhance the therapeutic activity of these CAMPs that include coadministration with nanoparticles and/or classic drugs.
New Targeted Treatments for Fragile X Syndrome
Authors: Protic Dragana , Salcedo-Arellano Maria J. , Dy Jeanne Barbara , Potter Laura A. , Hagerman Randi J.
Published: June 2019

Fragile X Syndrome (FXS) is the most common cause of inherited intellectual disability
with prevalence rates estimated to be 1:5,000 in males and 1:8,000 in females. The increase of
>200 Cytosine Guanine Guanine (CGG) repeats in the 5’ untranslated region of the Fragile X Mental
Retardation 1 (FMR1) gene results in transcriptional silencing on the FMR1 gene with a subsequent
reduction or absence of fragile X mental retardation protein (FMRP), an RNA binding protein
involved in the maturation and elimination of synapses. In addition to intellectual disability,
common features of FXS are behavioral problems, autism, language deficits and atypical physical
features. There are still no currently approved curative therapies for FXS, and clinical management
continues to focus on symptomatic treatment of comorbid behaviors and psychiatric problems.
Here we discuss several treatments that target the neurobiological pathway abnormal in FXS. These
medications are clinically available at present and the data suggest that these medications can be
helpful for those with FXS.
Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties
Authors: Jamalis Joazaizulfazli , Yusof Faten Syahira Mohamed , Chander Subhash , Wahab Roswanira Abd. , P. Bhagwat Deepak , Sankaranarayanan Murugesan , Almalki Faisal , Hadda Taibi Ben
Published: June 2019

Psoralen or furocoumarin is a linear three ring heterocyclic compound. Psoralens
are planar, tricyclic compounds, consisting of a furan ring fused to a coumarin moiety.
Psoralen has been known for a wide spectrum of biological activities, spanning from cytotoxic,
photosensitizing, insecticidal, antibacterial to antifungal effect. Thus, several structural
changes were introduced to explore the role of specific positions with respect to the
biological activity. Convenient approaches utilized for the synthesis of psoralen skeleton
can be categorized into two parts: (i) the preparation of the tricyclic ring system from resorcinol,
(ii) the exocyclic modification of the intact ring system. Furthermore, although
psoralens have been used in diverse ways, we mainly focus in this work on their clinical
utility for the treatment of psioraisis, vitiligo and skin-related disorder.
Portable Life Support System: Current Status and Future Perspectives
Authors: Jiang Jingang , Chen Yihao , Ma Xuefeng , Zhang Yongde , Huang Zhiyuan , Liang Dexian
Published: June 2019

Background:

Portable life support system is used in the battlefield, disaster and in other
special circumstances such as in space exploration, and underground survey to give the wounded a
life support. The most dangerous period for the injured is the first hour after an injury, which is a
crucial time for treatment. If the patient's vital signs were stabilized, more than 40% of the injured
could be saved. The staff can efficiently complete the task if they get effective and stable vital signs
during the operation. Therefore, in order to reduce the risk of disaster and battlefield mortality to
improve operational safety and efficiency, it is necessary to study the portable life support system.

Objective:

The study aimed to provide an overview of recent portable life support system and its
characteristics and design.

Methods:

This paper introduces the patents and products related to a portable life support system,
and its characteristics and application.

Results:

This paper summarizes five kinds of portable life support systems which are box type,
stretcher type, bed type, backpack type and mobile type. Moreover, the characteristics of different
portable life support systems are analyzed. The paper expounds the problems of different types of
portable life support systems and puts forward improvement methods to solve the problems. Finally,
the paper points out the future development of the system.

Conclusion:

Portable life support system plays an increasingly important role in health care. In
terms of the structure, function and control, further development and improvements are needed,
along with the research on portable life support system.
MicroRNAs: Crucial Regulators of Stress
Authors: Roufayel Rabih , kadry Seifedine
Published: June 2019

Background:

Signaling pathways including gene silencing, cellular differentiation, homeostasis,
development and apoptosis are regulated and controlled by a wide range of miRNAs.

Objective:

Due to their potential binding sites in human-protein coding genes, many studies have also
linked their altered expressions in various cancer types making them tumor suppressors agents.

Methods:

Moreover, each miRNA is predicted to have many mRNA targets indicating their extensive
regulatory role in cell survival and developmental processes. Nowadays, diagnosis of early cancer
stage development is now dependent on variable miRNA expression levels as potential oncogenic
biomarkers in validating and targeting microRNAs for cancer therapy.

Results:

As the majority of miRNA, transcripts are derived from RNA polymerase II-directed transcription,
stress response could result on a general reduction in the abundance of these transcripts.
Over expression of various microRNAs have lead to B cell malignancy, potentiated KrasG12Dinduced
lung tumorigenesis, chronic lymphocytic leukemia, lymphoproliferative disease and autoimmunity.

Conclusion:

Altered miRNA expressions could have a significant impact on the abundance of proteins,
making them attractive candidates as biomarkers for cancer detection and important regulators
of apoptosis.
Saussurea lappa: A Comprehensive Review on its Pharmacological Activity and Phytochemistry
Authors: Hassan Reyaz , Masoodi Mubashir Hussain
Published: June 2019

Around 3000 species of Saussurea are known, however Saussurea lappa Clarke
which is perennial herb and has been traditionally used as anticancer, anti-inflammatory,
antiviral, medicine without many adverse effects. Phytochemistry of Saussurea lappa after
thorough literature survey revealed various varied and copious metabolites such as sesquiterpenes,
flavonoids, phytosterols, lignans, terpenes. Many of these compounds have been
found to possess a wide range of biological activity such as anticancer, anti-inflammatory,
anti-hepatotoxic, anti-viral, etc. Among sesquiterpenes particularly Dehydrocostuslactone,
dihydrocostunolide, costunolide Lappadilactone, have been isolated as the main chemical
constituents. This review aims to cover published work from public databases (e.g. PubMed,
Google Scholar, ResearchGate) and Non-English, Ph.D./MS thesis databases (e.g. CKNIChina,
Jairo-Japan, Myto-Malaysia, Shodhganga-India) with a particular focus on
phytochemistry and therapeutic uses of different fractions as well as isolated compounds
from Saussurea lappa.
BOZUK KALIP ELEMANIN TERSİNE MÜHENDİSLİK UYGULAMASI İLE İMALATI
Authors: SOFU Mehmet Mahir
Published: June 2019

Metal
ve plastik enjeksiyon ile seri imalat yapan işletmelerin kilit elemanları
kalıplardır. Büyük baskı adetlerinin getirdiği yorgunluk, aşınma ve baskı
sırasında kalıp arasında sık parça sıkışması neticesinde oluşan yüksek
kuvvetler kalıp elemanlarının zamanla deforme olmasına neden olmaktadır. Bu
durumda kalıbın revize edilmesi veya bozuk parçaların yeniden imal edilesi
gerekmektedir. Doğrusal olmayan geometrideki parçaların imalatı için bilgisayar
ortamında üç boyutlu(3D) katı model verileri gerekmektedir. Eğer bu verilere
ulaşılmaz ise genellikle Tersine Mühendislik (TM) uygulaması yapılması
gerekmektedir. Bu çalışmada, tan itriyat sanayi ve tic. şti. firmasına ait
teknik resimleri ve 3D katı model verisi olmayan atıl durumdaki bir kalıbının
doğrusal olmayan yüzeye sahip bozuk bir parçasının TM uygulaması içerisinde 3D
tarayıcı ile tarama yaparak iki boyutlu (2D) tarama verileri elde edilmiş.
Çalışmada, TM uygulamasında geometrinin uzun süren matematiksel bağıntılara
ihtiyaç olmadan kısa süre içerisinde SolidWorks Bilgisayar Destekli Tasarım
programında (BDT) aşınmış olan bölgeleri kolay teknikler ile düzelterek katı model
elde edilmiştir. Elde edilen katı model bilgisayar destekli imalat (CAM)
yazılımı SolidCAM programında imalata hazırlanmış ve CNC dik işleme tezgâhında
imal edilmiştir. İmal edilen parça tekrar kalıba monte edilerek kalıptan
başarılı bir baskı alınmıştır. Aynı zamanda yeniden üretilen kalıp elemanı ile
kalıba ait olamayan başka bir ara ürün ile montajlı çalıştığı bilinmektedir. Bu
ara ürününde 2D tarama verileri ile karşılaştırmalı sonucu paylaşılmıştır.
Çalışmada, seri bir TM uygulaması yaparak yeni kalıp yapım maliyeti olmadan ve
örnek bir sürdürülebilir imalata örnek üretim yapılmıştır.
YAPI BİLGİ MODELLEMESİ (YBM) UYGULAMA PLANI ÜZERİNE İNCELEME
Authors: ATABAY Şenay , ÖZTÜRK Mehmet Baki
Published: June 2019

Yapım
firmaları ayakta kalabilmek için proje yönetimi ve planlamasını çok iyi
yapmalıdır. Bu yönetim süreci içerisinde disiplinler arası iletişim ve
koordinasyon eksikliğinden kaynaklanacak her türlü aksamanın, firma, devlet
kurumları ve dolayısıyla milli ekonomi üzerinde olumsuz etki oluşturması
kaçınılmazdır. Bu sorunların aşılması için disiplinler arası koordinasyonu
kolaylaştıracak teknikler kullanılmalıdır. Bu kapsamda, ülkemizde de kullanımı
yaygınlaşmakta olan Yapı Bilgi Modellemesi- YBM (Building Information Modeling-
BIM) sistemi oldukça verimli bir araç olarak uygulanmaktadır. Uluslararası
projelerde iş yapan Türk firmalar projelerinde YBM tecrübesi kazanmış olsalar
da bu tecrübeye sahip firma oranı düşüktür. Son yıllarda yerli sözleşmelerde
YBM yer almaya başlamıştır. Sözleşmeler ile oluşan YBM talebi, firmaların YBM
tecrübelerini artırmaya başlamıştır, ancak, YBM sisteminin uygulanmasında bazı
problemler ortaya çıkabilmektedir. Bu çalışmada, örnek bir proje üzerinde, YBM
uygulama planının Türkiye şartlarına uygun olabilecek süreçleri ortaya konmaya
çalışılmış ve süreçlerin detay seviyeleri, koordinasyon şekli, alt yapı için
gerekli öncüller ve model planlamaları oluşturulmuştur.
KAHRAMANMARAŞ İLİ DULKADİROĞLU BÖLGESİ KATI ATIK BİLEŞENLERİNİN ARAŞTIRILMASI
Authors: ZIBA Cengiz Ayhan , GÖKPUR Halil , DOLAZ Mustafa
Published: June 2019

Ülke ekonomisinin
gelişmesiyle birlikte kentleşme ve nüfus artışı da hızlanmakta ve buna bağlı
olarak çevresel atıklarda da büyük oranda artış görülmektedir. Oluşan bu
atıkların gömülerek veya yakılarak bertaraf edilmesi yerine geri kazanılması
için yeni teknolojilerin geliştirilmesi gerekmektedir. Geri kazanılabilecek
atıklardan endüstride kullanılabilecek hammadde elde edilmesi, hem endüstrinin
hammadde ihtiyacını hem de dışa bağımlılığı azaltarak ekonomiye katkı sağlanmış
olacaktır. Bu çalışmada 2017 yılı Nisan-Mayıs aylarında Kahramanmaraş ili Dulkadiroğlu
ilçesi sınırları içerisindeki konutlarda oluşan evsel katı atıklar, “Kent
Merkezi”, “Düşük Gelir Seviyesi”, “Orta Gelir Seviyesi” ve “Yüksek Gelir
Seviyesi”  olmak üzere, dört bölgeye
ayrılarak ele alınmış ve irdelenmiştir. Bu bölgelerden toplanan katı atık
bileşenlerinde en yüksek oranı % 55,90 ile mutfak
atıklarının, sonra sırasıyla % 12,50 ile plastik atıkların, % 9,80 ile diğer
yanabilen atıkların ve % 8 ile kâğıt atıklarının oluşturduğu görülmüştür.