bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine Learning-Based Models for Prediction of Critical Illness at Community, Paramedic, and Hospital Stages
Authors: Lee Sijin , Park Hyun Ji , Hwang Jumi , Lee Sung Woo , Han Kap Su , Kim Won Young , Jeong Jinwoo , Kang Hyunggoo , Kim Armi , Lee Chulung , Kim Su Jin
Published: June 2023

Overcrowding of emergency department (ED) has put a strain on national healthcare systems and adversely affected the clinical outcomes of critically ill patients. Early identification of critically ill patients prior to ED visits can help induce optimal patient flow and allocate medical resources effectively. This study aims to develop ML-based models for predicting critical illness in the community, paramedic, and hospital stages using Korean National Emergency Department Information System (NEDIS) data. Random forest and light gradient boosting machine (LightGBM) were applied to develop predictive models. The predictive model performance based on AUROC in community stage, paramedic stage, and hospital stage was estimated to be 0.870 (95% CI: 0.869–0.871), 0.897 (95% CI: 0.896–0.898), and 0.950 (95% CI: 0.949–0.950) in random forest and 0.877 (95% CI: 0.876–0.878), 0.899 (95% CI: 0.898–0.900), and 0.950 (95% CI: 0.950–0.951) in LightGBM, respectively. The ML models showed high performance in predicting critical illness using variables available at each stage, which can be helpful in guiding patients to appropriate hospitals according to their severity of illness. Furthermore, a simulation model can be developed for proper allocation of limited medical resources.
Generalized Complex-to-Complex Impedance Transformers Based on Conjugately Characteristic-Impedance Transmission Lines
Authors: Satitchantrakul Thanatcha , Boonpoonga Akkarat , Torrungrueng Danai
Published: June 2023

The novel technique of generalizing complex-to-complex impedance transformers (CCITs) with miniaturization is introduced in this paper. The generalized CCITs are designed based on conjugately characteristic-impedance transmission lines (CCITLs) along with the Meta-Smith charts (MSCs), resulting in convenient design equations. For illustration, a prototype of generalized CCITs is designed, simulated, and implemented with an asymmetric compact microstrip resonant cell (ACMRC), which is one of the CCITLs. The measurement results confirm that the proposed technique offers approximately 28.5% shorter in physical length compared to the CCIT designed using standard transmission lines.
Treatment of Combined Freckles with Chloasma Using Q-Switched 1064 nm Laser
Authors: Zheng Han , Qiao Gang , Zhang Yong
Published: June 2023

Objective. The present study observed the therapeutic effect and possible side effects of Q-switch 1064-nm laser with large-spot and low-energy technology in the treatment of patients with combined freckles and chloasma. Methods. A Q1064-nm laser with a large-spot diameter of 6–8 mm, energy level of 2.0–3.3 J/cm2, frequency of 10 Hz, and pulse width of 10 ns was employed for the treatment. Each patient underwent treatment 10–15 times, with an interval of 10–15 days each time. Facial care was administered before and after treatment; attention was paid to cleaning and moisturizing, avoiding light, and using sunscreens strictly. The therapeutic effects were observed and evaluated. Results. Freckles basically subsided (effective rate = 100%) and chloasma faded (effective rate = 39.4%). Furthermore, whitening and delicacy improvement were observed in the surrounding normal skin area. After laser treatment, confocal laser scanning microscopy revealed a large number of melanin particles in the upper part of the granular layer. Moreover, the amount of melanin in the middle and lower parts of the basal layer and spinous layer was significantly decreased. None of the patients developed postinflammatory pigmentation. Conclusion. In the treatment of freckles with chloasma, Q 1064-nm laser large-spot, low-energy technology not only removed freckles and faded chloasma but, most importantly, also reduced the incidence of postinflammatory pigmentation and improved patient satisfaction. This provided new methods and ideas for freckle laser treatment.
Drug-Coated Balloon in Primary Percutaneous Coronary Intervention
Authors: Zhao Hui , Miao Runran , Lin Fei , Zhao Guoan
Published: June 2023

According to the latest coronary interventional guidelines, a drug-eluting stent is the recommended reperfusion therapy in primary percutaneous coronary intervention (pPCI). However, deficiencies and defects, such as in-stent restenosis (ISR), incomplete stent apposition, stent thrombosis, reinfarction after stent implantation, long-term dual antiplatelet drug use, and adverse reactions of metal implants, plague clinicians and patients. Drug-coated balloon (DCB), which delivers antiproliferative agents into the vessel wall without stent implantation and leaves no implants behind after the procedure, is a novel option for percutaneous coronary intervention and has proven to be a promising strategy in cases of ISR, small vessel coronary artery disease, and bifurcation lesions. However, most of the available experience has been gained in elective percutaneous coronary intervention, and experience in pPCI is lacking. The current evidence for the use of DCB-only in pPCI was discussed and analyzed in this review.
Catalytic Pyrolysis of Plastic Waste to Liquid Fuel Using Local Clay Catalyst
Authors: Mibei Zeddy C. , Kumar Anil , Talai Stephen M.
Published: June 2023

Plastics are nonbiodegradable, and safe disposal of this waste poses an environmental challenge all over the world. Catalytic pyrolysis is superior to thermal pyrolysis as it uses lower temperatures and hence less energy. The main objective of this study was to produce liquid fuel from plastic waste using indigenous clay as a catalyst through catalytic pyrolysis. The clay from Kisumu County was characterized through an X-ray fluorescence spectrometer (XRFS) and an X-ray diffractometer (XRD). The reaction setup consisted of a round-bottom flask reactor through which plastic feed and catalyst were heated in a temperature-controlled furnace. Vapor product was condensed using a Liebig type water condenser to give pyrolysis liquid product. Solid char was recovered from the flask at the end of the reaction. Optimization studies using central composite design (CCD) and response surface methodology (RSM) were performed in design expert software to predict optimal conditions of the operating variables for maximum yield of the liquid fuel. Results show that clay has a composition of silica and alumina at 64.5 wt% and 16.3 wt%, respectively, indicating high acidity of the clay, being a requirement for a good pyrolysis catalyst. For high-density polyethylene and polypropylene, the highest liquid yield of 87.23 wt% and 60.36 wt%, respectively, was at 300°C and a catalyst concentration of 10 wt%. Indigenous clay was established to be a suitable catalyst for catalytic pyrolysis of plastic waste, with the potential to replace imported catalysts since high yields of liquid fuel were obtained at lower reaction temperatures of 300-450°C, as compared to the 600°C required for thermal pyrolysis. In conclusion, waste plastics can be used to generate alternative fuel for industrial use. The liquid fuel can be used in diesel engines as a transport fuel, in turbines for electricity generation, and as a heating source in boilers and furnaces. Further studies on the modification of the surface and structure of clay are suggested to enhance its catalytic performance in the pyrolysis process for a better fuel yield.
Mutant KRAS Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma
Authors: Kong Yao , Luo Yuming , Zheng Shangyou , Yang Jiabin , Zhang Dingwen , Zhao Yue , Zheng Hanhao , An Mingjie , Lin Yan , Ai Le , Diao Xiayao , Lin Qing , Chen Changhao , Chen Rufu
Published: June 2023

Circular RNAs (circRNA) contribute to cancer stemness, proliferation, and metastasis. The biogenesis of circRNAs can be impacted by the genetic landscape of tumors. Herein, we identified a novel circRNA, circARFGEF2 (hsa_circ_0060665), which was upregulated in KRASG12D pancreatic ductal adenocarcinoma (PDAC) and positively associated with KRASG12D PDAC lymph node (LN) metastasis. CircARFGEF2 overexpression significantly facilitated KRASG12D PDAC LN metastasis in vitro and in vivo. Mechanistically, circARFGEF2 biogenesis in KRASG12D PDAC was significantly activated by the alternative splicing factor QKI-5, which recruited U2AF35 to facilitate spliceosome assembly. QKI-5 bound the QKI binding motifs and neighboring reverse complement sequence in intron 3 and 6 of ARFGEF2 pre-mRNA to facilitate circARFGEF2 biogenesis. CircARFGEF2 sponged miR-1205 and promoted the activation of JAK2, which phosphorylated STAT3 to trigger KRASG12D PDAC lymphangiogenesis and LN metastasis. Importantly, circARFGEF2 silencing significantly inhibited LN metastasis in the KrasG12D/+Trp53R172H/+Pdx-1-Cre (KPC) mouse PDAC model. These findings provide insight into the mechanism and metastasis-promoting function of mutant KRAS-mediated circRNA biogenesis.

Significance:

Increased splicing-mediated biogenesis of circARFGEF2 in KRAS-mutant pancreatic ductal adenocarcinoma activates JAK2–STAT3 signaling and triggers lymph node metastasis, suggesting circARFGEF2 could be a therapeutic target to inhibit pancreatic cancer progression.
Safety and Efficacy of Tucatinib, Letrozole, and Palbociclib in Patients with Previously Treated HR+/HER2+ Breast Cancer
Authors: Shagisultanova Elena , Gradishar William , Brown-Glaberman Ursa , Chalasani Pavani , Brenner Andrew J. , Stopeck Alison , Parris Hannah , Gao Dexiang , McSpadden Tessa , Mayordomo Jose , Diamond Jennifer R. , Kabos Peter , Borges Virginia F.
Published: June 2023

Purpose:

To overcome resistance to antihormonal and HER2-targeted agents mediated by cyclin D1-CDK4/6 complex, we proposed an oral combination of the HER2 inhibitor tucatinib, aromatase inhibitor letrozole, and CDK4/6 inhibitor palbociclib (TLP combination) for treatment of HR+/HER2+ metastatic breast cancer (MBC).

Patients and Methods:

Phase Ib/II TLP trial (NCT03054363) enrolled patients with HR+/HER2+ MBC treated with ≥2 HER2-targeted agents. The phase Ib primary endpoint was safety of the regimen evaluated by NCI CTCAE version 4.3. The phase II primary endpoint was efficacy by median progression-free survival (mPFS).

Results:

Forty-two women ages 22 to 81 years were enrolled. Patients received a median of two lines of therapy in the metastatic setting, 71.4% had visceral disease, 35.7% had CNS disease. The most common treatment-emergent adverse events (AE) of grade ≥3 were neutropenia (64.3%), leukopenia (23.8%), diarrhea (19.0%), and fatigue (14.3%). Tucatinib increased AUC10–19 hours of palbociclib 1.7-fold, requiring palbociclib dose reduction from 125 to 75 mg daily. In 40 response-evaluable patients, mPFS was 8.4 months, with similar mPFS in non-CNS and CNS cohorts (10.0 months vs. 8.2 months; P = 0.9). Overall response rate was 44.5%, median duration of response was 13.9 months, and clinical benefit rate was 70.4%; 60% of patients were on treatment for ≥6 months, 25% for ≥1 year, and 10% for ≥2 years. In the CNS cohort, 26.6% of patients remained on study for ≥1 year.

Conclusions:

TLP combination was safe and tolerable. AEs were expected and manageable with supportive therapy and dose reductions. TLP showed excellent efficacy for an all-oral chemotherapy-free regimen warranting further testing.

See related commentary by Huppert and Rugo, p. 4993
Supplementary Table S4 from Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis
Authors: Goldman Omer , Adler Lital N. , Hajaj Emma , Croese Tommaso , Darzi Naama , Galai Sivan , Tishler Hila , Ariav Yarden , Lavie Dor , Fellus-Alyagor Liat , Oren Roni , Kuznetsov Yuri , David Eyal , Jaschek Rami , Stossel Chani , Singer Oded , Malitsky Sergey , Barak Renana , Seger Rony , Erez Neta , Amit Ido , Tanay Amos , Saada Ann , Golan Talia , Rubinek Tamar , Sang Lee Joo , Ben-Shachar Shay , Wolf Ido , Erez Ayelet
Published: June 2023

Supplementary Table S4 lists the antibodies used for FACS
Supplementary Table S2 from Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis
Authors: Goldman Omer , Adler Lital N. , Hajaj Emma , Croese Tommaso , Darzi Naama , Galai Sivan , Tishler Hila , Ariav Yarden , Lavie Dor , Fellus-Alyagor Liat , Oren Roni , Kuznetsov Yuri , David Eyal , Jaschek Rami , Stossel Chani , Singer Oded , Malitsky Sergey , Barak Renana , Seger Rony , Erez Neta , Amit Ido , Tanay Amos , Saada Ann , Golan Talia , Rubinek Tamar , Sang Lee Joo , Ben-Shachar Shay , Wolf Ido , Erez Ayelet
Published: June 2023

Supplementary Table S2 lists the antibodies used for western blots
Supplementary Figure S4 from Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis
Authors: Goldman Omer , Adler Lital N. , Hajaj Emma , Croese Tommaso , Darzi Naama , Galai Sivan , Tishler Hila , Ariav Yarden , Lavie Dor , Fellus-Alyagor Liat , Oren Roni , Kuznetsov Yuri , David Eyal , Jaschek Rami , Stossel Chani , Singer Oded , Malitsky Sergey , Barak Renana , Seger Rony , Erez Neta , Amit Ido , Tanay Amos , Saada Ann , Golan Talia , Rubinek Tamar , Sang Lee Joo , Ben-Shachar Shay , Wolf Ido , Erez Ayelet
Published: June 2023

Supplementary Figure S4 demonstrates similar transcriptional and metabolic changes following liver infiltration of immune cells to the liver of PDAC mice
Supplementary Figure S2 from Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis
Authors: Goldman Omer , Adler Lital N. , Hajaj Emma , Croese Tommaso , Darzi Naama , Galai Sivan , Tishler Hila , Ariav Yarden , Lavie Dor , Fellus-Alyagor Liat , Oren Roni , Kuznetsov Yuri , David Eyal , Jaschek Rami , Stossel Chani , Singer Oded , Malitsky Sergey , Barak Renana , Seger Rony , Erez Neta , Amit Ido , Tanay Amos , Saada Ann , Golan Talia , Rubinek Tamar , Sang Lee Joo , Ben-Shachar Shay , Wolf Ido , Erez Ayelet
Published: June 2023

Supplementary Figure S2 demonstrates the infiltration of mature innate immune cells to the liver during breast carcinogenesis
Supplementary Table S15 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia
Authors: Sabatier Marie , Birsen Rudy , Lauture Laura , Mouche Sarah , Angelino Paolo , Dehairs Jonas , Goupille Léa , Boussaid Ismael , Heiblig Maël , Boet Emeline , Sahal Ambrine , Saland Estelle , Santos Juliana C. , Armengol Marc , Fernández-Serrano Miranda , Farge Thomas , Cognet Guillaume , Simonetta Federico , Pignon Corentin , Graffeuil Antoine , Mazzotti Céline , Avet-Loiseau Hervé , Delos Océane , Bertrand-Michel Justine , Chedru Amélie , Dembitz Vilma , Gallipoli Paolo , Anstee Natasha S. , Loo Sun , Wei Andrew H. , Carroll Martin , Goubard Armelle , Castellano Rémy , Collette Yves , Vergez François , Mansat-De Mas Véronique , Bertoli Sarah , Tavitian Suzanne , Picard Muriel , Récher Christian , Bourges-Abella Nathalie , Granat Fanny , Kosmider Olivier , Sujobert Pierre , Colsch Benoit , Joffre Carine , Stuani Lucille , Swinnen Johannes V. , Guillou Hervé , Roué Gael , Hakim Nawad , Dejean Anne S. , Tsantoulis Petros , Larrue Clément , Bouscary Didier , Tamburini Jerome , Sarry Jean-Emmanuel
Published: June 2023

Table S15: Relative quantification by lipid class
Supplementary Table S13 from C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia
Authors: Sabatier Marie , Birsen Rudy , Lauture Laura , Mouche Sarah , Angelino Paolo , Dehairs Jonas , Goupille Léa , Boussaid Ismael , Heiblig Maël , Boet Emeline , Sahal Ambrine , Saland Estelle , Santos Juliana C. , Armengol Marc , Fernández-Serrano Miranda , Farge Thomas , Cognet Guillaume , Simonetta Federico , Pignon Corentin , Graffeuil Antoine , Mazzotti Céline , Avet-Loiseau Hervé , Delos Océane , Bertrand-Michel Justine , Chedru Amélie , Dembitz Vilma , Gallipoli Paolo , Anstee Natasha S. , Loo Sun , Wei Andrew H. , Carroll Martin , Goubard Armelle , Castellano Rémy , Collette Yves , Vergez François , Mansat-De Mas Véronique , Bertoli Sarah , Tavitian Suzanne , Picard Muriel , Récher Christian , Bourges-Abella Nathalie , Granat Fanny , Kosmider Olivier , Sujobert Pierre , Colsch Benoit , Joffre Carine , Stuani Lucille , Swinnen Johannes V. , Guillou Hervé , Roué Gael , Hakim Nawad , Dejean Anne S. , Tsantoulis Petros , Larrue Clément , Bouscary Didier , Tamburini Jerome , Sarry Jean-Emmanuel
Published: June 2023

Table S13: lipidomic results by lipid species in dox-inducible and constitutives shRNAs and siRNA CTL/CEBPA, empty vector/CEBPA-OE and vehicle/QUIZ conditions in MOLM-14 cells
Supplementary Table 5 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Authors: McNicholas Michael , De Cola Antonella , Bashardanesh Zahedeh , Foss Amelia , Lloyd Cameron B. , Hébert Steven , Faury Damien , Andrade Augusto Faria , Jabado Nada , Kleinman Claudia L. , Pathania Manav
Published: June 2023

Cell type ontologies derived from snRNA-seq data.
TABLE 2 from NCI 7977: A Phase I Dose-Escalation Study of Intermittent Oral ABT-888 (Veliparib) plus Intravenous Irinotecan Administered in Patients with Advanced Solid Tumors
Authors: Cecchini Michael , Walther Zenta , Wei Wei , Hafez Navid , Pilat Mary Jo , Boerner Scott A. , Durecki Diane E. , Eder Joseph P. , Schalper Kurt A. , Chen Alice P. , LoRusso Patricia
Published: June 2023

Treatment-related frequency of adverse events and laboratory abnormalities
Table S3 from Immunological characterization and T-cell receptor repertoires of expanded tumor-infiltrating lymphocytes in renal cell carcinoma patients
Authors: Lee Moon Hee , Theodoropoulos Jason , Huuhtanen Jani , Bhattacharya Dipabarna , Järvinen Petrus , Tornberg Sara , Nísen Harry , Mirtti Tuomas , Uski Ilona , Kumari Anita , Peltonen Karita , Draghi Arianna , Donia Marco , Kreutzman Anna , Mustjoki Satu
Published: June 2023

Supplementary Table S3 shows the sample availability, usage and TIL expansion potentials.
Figure S7 from Immunological characterization and T-cell receptor repertoires of expanded tumor-infiltrating lymphocytes in renal cell carcinoma patients
Authors: Lee Moon Hee , Theodoropoulos Jason , Huuhtanen Jani , Bhattacharya Dipabarna , Järvinen Petrus , Tornberg Sara , Nísen Harry , Mirtti Tuomas , Uski Ilona , Kumari Anita , Peltonen Karita , Draghi Arianna , Donia Marco , Kreutzman Anna , Mustjoki Satu
Published: June 2023

Figure S7 shows analyses of the co-culture assays involving CD107a/b, IFN-y,TNF-a and GzB expressions.
Figure S6 from Immunological characterization and T-cell receptor repertoires of expanded tumor-infiltrating lymphocytes in renal cell carcinoma patients
Authors: Lee Moon Hee , Theodoropoulos Jason , Huuhtanen Jani , Bhattacharya Dipabarna , Järvinen Petrus , Tornberg Sara , Nísen Harry , Mirtti Tuomas , Uski Ilona , Kumari Anita , Peltonen Karita , Draghi Arianna , Donia Marco , Kreutzman Anna , Mustjoki Satu
Published: June 2023

Figure S6 shows the flow cytometric analyses of the immune cell subsets, T-cell phenotypes, and marker expressions, as well as correlation analyses between the T-cell subsets and the expansion potential (fold-change of REP TILs/pre-REP TILs).
Figure S3 from Immunological characterization and T-cell receptor repertoires of expanded tumor-infiltrating lymphocytes in renal cell carcinoma patients
Authors: Lee Moon Hee , Theodoropoulos Jason , Huuhtanen Jani , Bhattacharya Dipabarna , Järvinen Petrus , Tornberg Sara , Nísen Harry , Mirtti Tuomas , Uski Ilona , Kumari Anita , Peltonen Karita , Draghi Arianna , Donia Marco , Kreutzman Anna , Mustjoki Satu
Published: June 2023

Figure S3 shows representative gating strategies for the immune subset populations and T-cell subtypes for the healthy kidney, tumor, pre-REP TIL and REP TIL samples.
Figure S12 from Immunological characterization and T-cell receptor repertoires of expanded tumor-infiltrating lymphocytes in renal cell carcinoma patients
Authors: Lee Moon Hee , Theodoropoulos Jason , Huuhtanen Jani , Bhattacharya Dipabarna , Järvinen Petrus , Tornberg Sara , Nísen Harry , Mirtti Tuomas , Uski Ilona , Kumari Anita , Peltonen Karita , Draghi Arianna , Donia Marco , Kreutzman Anna , Mustjoki Satu
Published: June 2023

Figure S12 shows the validation of RCC-associated TCR motifs in various cohorts.
Lower Body Mass Index and Prognostic Nutritional Index Are Associated with Poor Posttransplant Outcomes in Lymphoma Patients Undergoing Autologous Stem Cell Transplantation
Authors: Yucel Orhan Kemal , Vural Ece , Alhan Nurcan , Vurgun Sertac , Atas Unal , Yapar Dilek , Alemdar Mustafa Serkan , Karaca Mustafa , Iltar Utku , Salim Ozan , Undar Levent
Published: June 2023

Introduction: Pretransplant inflammatory and nutritional status has not been widely explored in terms of its impact on autologous hematopoietic stem cell transplantation (auto-HSCT) outcomes in lymphoma patients. We aimed to evaluate the impact of body mass index (BMI), prognostic nutritional index (PNI), and C-reactive protein to albumin ratio (CAR) on auto-HSCT outcomes. Methods: We retrospectively analyzed 87 consecutive lymphoma patients who underwent their first auto-HSCT at the Adult Hematopoietic Stem Cell Transplantation Unit at Akdeniz University Hospital. Results: The CAR had no impact on posttransplant outcomes. PNI ≤50 was an independent prognostic factor for both shorter progression-free survival (PFS) (hazard ratio [HR] = 2.43, p = 0.025) and worse overall survival (OS) (HR = 2.93, p = 0.021), respectively. The 5-year PFS rate was significantly lower in patients with PNI ≤50 than in patients with PNI >50 (37.3% vs. 59.9%, p = 0.003). The 5-year OS rate in patients with PNI ≤50 was significantly low when compared with patients who had PNI >50 as well (45.5% vs. 67.2%, p = 0.011). Patients with BMI <25 had higher 100-day transplant-related mortality compared with patients with BMI ≥25 (14.7% vs. 1.9%, p = 0.020). BMI <25 was an independent prognostic factor associated with shorter PFS and OS (HR = 2.98 [p = 0.003], HR = 5.06 [p < 0.001], respectively). The 5-year PFS rate was significantly lower in patients with BMI <25 than patients with BMI ≥25 (40.2% vs. 53.7%, p = 0.037). Similarly, the 5-year OS rate in patients with BMI <25 was significantly inferior compared to patients with BMI ≥25 (42.7% vs. 64.7%, p = 0.002). Conclusion: Our study confirms that lower BMI and CAR have negative impacts on auto-HSCT outcomes in lymphoma patients. Furthermore, higher BMI should not be considered an obstacle for lymphoma patients who need auto-HSCT; conversely, it could be an advantage for posttransplant outcomes.
ERT geoelectric application to determine the leakage direction of Embung Batur Agung, Karangwetan, Karangmojo District, Gunungkidul Regency, Indonesia
Authors: Zakaria Muhammad Faizal , Kusumayudha Sari Bahagiarti , Hamid Hanafiah
Published: June 2023

Embung Batur Agung is a source of irrigation for residents around Embung. Depreciation of water in the reservoir occurs due to leakage from the geomembrane layer of the Embung Batur Agung. This study aims to determine the direction of leakage from the reservoir so that appropriate treatment can be carried out. This research was done using hydrogeological analysis and electrical resistivity tomography (ERT) geoelectrical measurements. ERT Geoelectrical measurement uses a dipole-dipole configuration with a spacing of 5 m and 10 m and a line length of 100 m. There are 2 lines in the southwest and southeast of the reservoir. The results of geohydrology analysis, it was found that the aquifer system around the reservoir included in the Gunungsewu aquifer system, and the dynamics of surface groundwater are controlled by faults and fractures. The results of the ERT geoelectrical measurement, there is a low anomaly which can indicate a reservoir leak at 50-60 m on line 1 which is in the southwest of the reservoir. This low anomaly has a vertical pattern as well as there is a fracture which is the cause of the reservoir leak. These low anomaly values range from 4-30 Ωm which can be interpreted as the presence of water that has conductive properties. The results of this study are expected to be used by the local government to handle the leakage of the reservoir.
Predation of the Nicobar Shrew Crocidura nicobarica by a Cattle Egret Bubulcus ibis
Authors: G. Gokulakrishnan  , C.S. Vishnu  , Manokaran Kamalakannan
Published: June 2023

The Nicobar Shrew Crocidura nicobarica (Miller, 1902) is an endemic and ‘Critically Endangered’ species restricted to Great Nicobar Island in the Andaman Sea, India. Predation instance on the Nicobar Shrew by a Cattle Egret is reported herewith for the first time in the littoral forests near Govind Nagar, Great Nicobar Island.
Integrative taxonomic revision of the African taxa of the Racotis Moore, 1887 generic complex (Lepidoptera, Geometridae, Ennominae, Boarmiini)
Authors: LÁSZLÓ GYULA M. , HAUSMANN AXEL , KARISCH TIMM
Published: June 2023

The Afrotropical taxa of the Racotis s.l. generic complex are revised utilising integrative taxonomical methods. Based on the evaluation of genital morphology and analyses of DNA barcodes, a new genus, Afroracotis gen. n. is established to include the Afrotropical “Racotis” species. The new genus is subdivided into 5 subgenera: Afroracotis subgen. n., Herbuloracotis subgen. n., Rwandaracotis subgen. n., Zebracotis subgen. n. and Sokokeracotis subgen. n.. A new monotypic genus is described to include Boarmia ugandaria Swinhoe, 1904 which was combined earlier with the genus Chorodna and recently with Racotis: Chorocotis gen. n.. Two species formerly assigned to Cleora are moved to Afroracotis: A. albitrigonis (Prout, 1927) comb. n., A. atriclava (Prout, 1926) comb. n.. Two species are transferred from Racotis to Colocleora: C. breijeri (Prout, 1922) comb. n., C. incauta (Prout, 1916) comb. n.. Seventeen new Afroracotis species (A. aliena, A. stadiei, A. violetteae, A. fiebigi, A. turlini, A. dargei, A. longicornuta, A. aristophanousi, A. muscivirens, A. chaineyi, A. lydiae, A. smithi, A. ochsei, A. milesi, A. helicalis, A. takanoi and A. staudei spp. n.) and 5 new subspecies (A. squalida thomensis, A. argillacea morettoi, A. longicornuta congolana, A. longicornuta ugandana and A. lydiae orientalis sspp. n.) are described, totalling 27 species and 8 subspecies contained in the genus Afroracotis. Adults and genitalia of all taxa are illustrated in 210 colour and 129 black and white figures demonstrating the intraspecific variability. The distribution of all taxa is illustrated in 6 dot maps. The results of the genetic analyses are figured in four phylograms.
Justifying contentious social and political claims using mundane language: An analysis of Canadian right-wing extremism
Authors: Preston Kayla
Published: June 2023

There has been a lack of research examining how right-wing extremist groups justify their key claims online to reach a broader audience. This question is even more worrisome when considering a Canadian context, given Canada’s state policies on multiculturalism and intolerance of hateful rhetoric. My research draws on the gaps within the literature of right-wing extremism, online spaces, and justification of discourse by conducting a content analysis of 300 Facebook and Twitter posts from the accounts of three Canadian right-wing extremist groups, ID Canada, Soldiers of Odin BC, and Yellow Vests Canada. This article proposes the use of French theorist Boltanski and Thévenot’s sociology of critical capacity common worlds to help explain how right-wing extremist groups make arguments that are quite extreme to a broad audience of people on social media. Such claims include advocating for a homogenized Canadian identity and Canadian values, promoting a belief in social decay, and supporting authoritarianism. However, these claims are not overt; rather right-wing extremist groups discuss apolitical topics to mask controversial views.
Contesting the Black Flâneur: The rhetoric of disruption and Ubah Cristina Ali Farah's urban literature
Authors: Liu Qian
Published: June 2023

This article investigates the spatial poetics of disruption in Ubah Cristina Ali Farah's second novel Il comandante del fiume. The book sets a unique stage around fragmented flashbacks to resignify the configuration of Afro-Italian urban identity and community. These flashbacks are rendered through a complicated recoding of Rome's urbanscape by its protagonist, Yabar, a young Somali immigrant who experiences a mysterious disfigurement of his body and narrates his past as he recuperates in the hospital. The Black body thus becomes the primary shifting site through which new paradigms of spatial arrangements against power and authority are articulated. This article argues that, by having Yabar fantasize, observe, and live through Rome's urban physicality, Ali Farah delineates a poetics of disruption that functions to redraw the conceptual boundaries of Blackness and postcoloniality in contemporary Italy. Ali Farah's experiment with the city as an actual character de-romanticizes it as a historical fixed site, and instead displays the possibility of plurality in the shape of Black corporeal relationality in determined stances. In this novel, not as observed objects, the protagonists remap Rome as a Black city and carry forward a Benjaminian mode of flâneur to observe the city's fragmented and chaotic arrangements, demystifying its undercurrent construction of racial exclusion.
An Olive Agenda as an accompaniment model of mission
Authors: Barnes Jonathan S. , Konkol Brian
Published: June 2023

The engagement of Christians in working to help alleviate suffering in the world is a biblical mandate. During the era of industrialization and colonial expansion, the idea of social and economic progress dominated the Western mind so that indigenous cultures and ways of life were judged through a lens of evolution, development, and so-called economic growth. This view was further entrenched after World War II and, for decades now, international development has been part of the church’s involvement in mission. Despite these efforts, the gap between the “haves” and “have nots” in our world continues to grow. Additionally, the divide created between “receiver/objects” and “giver/subjects” mitigates the chance of meaningful sharing to take place. In response to this history, Christians in the so-called Western world need to search for models of mission engagement not based on the presuppositions that undergirded previous efforts. An accompaniment model of mission, grounded in a theoretical foundation such as South African scholar and activist Steve de Gruchy’s Olive Agenda, can serve as a needed corrective to common Western notions of community development.
A word from a seminarian . . . Beth Moore, the Great Goddess: Rushing’s feminine archetypes and the “Go home” controversy
Authors: Metcalf Delaney Jordan
Published: June 2023

Society employs feminine archetypes to construct rigid standards and expectations for women. The Southern Baptist Convention (SBC) uses interpretation of selected biblical texts to construct the feminine archetype of “the submissive woman,” a tactic not unlike the patriarchal subversion of the Great Goddess myth. The SBC expects women to submit to the authority of men and to teachings that exclude women from holding leadership positions. This article examines the ongoing debate over the role of women within the SBC, using the statements of John MacArthur and Beth Moore as artifact and exemplar, including a comparison of their competing interpretations of the New Testament figure Phoebe.
Virtual Simulations to Practice Whole Group Discussions: Preservice Teachers’ Metacognitive Awareness
Authors: Ford Deana J. , Luke Sara E. , Vaughn S. Michelle , Fulchini-Scruggs Angelica
Published: June 2023

The purpose of this study was to investigate the impact explicit teaching of metacognition had on preservice teachers’ metacognitive awareness and accuracy of whole group discussions using virtual simulations. One class of preservice teachers was randomly assigned to the explicit metacognitive teaching group, while the other class was assigned to the information-only group. A total of 40 nontraditional preservice teachers participated in the research study. A pre-, mid-, and post-assessment quasi-experimental design was employed. The independent variables were the two training groups (explicit metacognitive teaching group and information-only group). The dependent variables were preservice teachers’ self-reported metacognitive awareness, the researchers’ metacognitive awareness rubric scores, and metacognitive accuracy. The results revealed that engaging in the virtual simulation experiences improved preservice teachers’ metacognitive awareness of leading a whole group discussion and that preservice teachers were overconfident in assessing their metacognitive awareness.
Multiaccentual coalitions, dialogic grief and carnivalesque assemblies: Judith Butler and Mikhail Bakhtin meet in the world of ethics
Authors: Roberts John M.
Published: June 2023

This article for the first time seeks to bring together theoretical insights from Judith Butler and Mikhail Bakhtin in order to strengthen their respective understanding of ethics. First, the article suggests that Bakhtin’s theory of dialogic events and the ‘multiaccentuality’ and thematic nature of everyday utterances can help Butler address criticisms that suggest her work concentrates too heavily on invariant meanings in utterances. Second, Butler’s theory of coalitions can usefully politicise Bakhtin’s ideas on utterances, while her ethics of grief is a crucial way to think about how we forge bonds with the ‘Other’. Correspondingly, Bakhtin’s theory of the ethical ‘I’ adds an important moment of ‘empathy’ to Butler’s account of grief and the ‘Other’. Third, Butler’s theory of state hegemony and counter-hegemonic assemblies can provide an important addition to Bakhtin’s theory, while Bakhtin’s theory of carnivalesque democracy strengthens Butler’s insights on equality in assemblies and occupying a liveable life.
How Obsessive-Compulsive Symptoms Correlate with other Symptoms and Quality of Life in Schizophrenia? A Cross-Sectional Study
Authors: Awasthi Snigdha , Satapthy Ramananda
Published: June 2023

Background:

Early psychiatrists inferred that obsessive-compulsive symptoms (OCS) represent a defense against psychosis and prevent the progression of schizophrenia. However, recent clinical research has yielded inconsistent results across studies regarding the link between OCS and the symptom domains of schizophrenia and the influence OCS have on a patient’s functioning and quality of life (QOL). This study aimed to determine whether OCS has any association with the symptom severity, functioning, and QOL of schizophrenia patients.

Methods:

This cross-sectional study done in a tertiary care hospital consecutively recruited 85 outpatients of schizophrenia in clinical remission over one year. Positive and Negative Syndrome Scale (PANSS), Yale-Brown Obsessive Compulsive Scale (Y-BOCS), WHO Quality of Life Brief Version (WHO QOL-BREF), and Global Assessment of Functioning (GAF) scales were applied.

Results:

Eighteen patients (21.2%) had OCS (Y-BOCS score of ≥8). Patients with OCS had higher PANSS scores (mean±SD of total score 77.16± 16.4, P < 0.001), suggestive of more severe psychosis, poor functioning overall (mean GAF score 37.35 ± 15.62, P < 0.001), and poor QOL in the psychological domain (P < 0.001). In addition, significant associations were present between the Y-BOCS score and the PANSS ( r = 0.65), GAF ( r = –0.61), and WHO QOL BREF scores in the physical ( r = –0.39), and psychological domains ( r = –0.41) (P < 0.001 on all of the above).

Conclusions:

Patients with OCS have more severe symptoms and a lower QOL. A significant association exists between the intensity of OCS and schizophrenia symptoms, global functioning, and QOL.
Impact of a First-In–First-Out Rule on the Merge of a Metro Line with a Junction
Authors: Farrando Rodolphe , Farhi Nadir , Christoforou Zoi , Urban Alain
Published: June 2023

On a metro line with a junction, the merge of the line is a key point for the operation. This paper proposes a discrete event traffic model for a metro line with a junction. It is based on the line’s existing signaling system and determines trains’ departure times at all line nodes. Furthermore, the model estimates trains’ average headway and frequency. We apply our model to Paris metro line 13, which is currently not operated with a FIFO (first-in–first-out) rule on the merge. Thus, we seek to evaluate the effect of a FIFO rule on the nominal frequency. Compared to the current line operation, we also test the FIFO rule as a control strategy for daily disturbances. At the steady state, we show that the train frequency is maximized regardless of the distribution of the trains on the three parts of the line (the central part and two branches). Then, we study the train frequency in two disturbed situations that often occur on a metro line. We show that the FIFO rule reduces the impact of these disturbances in time and intensity. This research is motivated by the Paris metro operator, as the considered line is expected to be fully automated in the coming years. The operator wants to better understand the potential benefits of new operating rules and how operating protocols can improve the throughput and reliability of the system. This work is the first step in seeing frequency evolution on a line with a junction.
Piperacillin-Tazobactam Versus Anti-Pseudomonal Cephalosporins and Renal and Neurologic Outcomes in Critically Ill Adults: A Secondary Analysis of the SMART Trial
Authors: Qian Edward T. , Wang Li , Stollings Joanna L. , Casey Jonathan D. , Rice Todd W. , Semler Matthew W.
Published: June 2023

Background: Prior studies suggest associations between receipt of piperacillin-tazobactam and development of acute kidney injury and receipt of anti-pseudomonal cephalosporins and neurotoxicity. We compared clinically-relevant renal and neurologic outcomes in critically ill patients who received piperacillin-tazobactam versus anti-pseudomonal cephalosporins. Methods: We conducted a secondary analysis of data from the Isotonic Solutions and Major Adverse Renal Events Trial examining patients who received piperacillin-tazobactam or an anti-pseudomonal cephalosporin within 24 h of intensive care unit admission. We performed multivariable analysis using a proportional odds model to examine the association between the first antibiotic received and the outcomes of Major Adverse Kidney Events within 30 days (MAKE30) and days alive and free of delirium and coma to day 28. Results: 3199 were included in the study; 2375 (74%) receiving piperacillin-tazobactam and 824 (26%) receiving anti-pseudomonal cephalosporin. After adjustment for prespecified confounders, initial receipt of piperacillin-tazobactam, compared to anti-pseudomonal cephalosporins, was not associated with higher incidence of MAKE30 (adjusted odds ratio, 1.03; 95% CI, 0.83-1.27; P = .80) but was associated with a greater number of days alive and free of delirium and coma (adjusted odds ratio, 1.18; 95% CI, 1.00-1.38; P = .04). In a sensitivity analysis adjusting for baseline receipt of medications which may impact neuro function, this finding was not significant. Conclusion: Among critically ill adults, receipt of piperacillin-tazobactam was not associated with an increased incidence of death, renal replacement therapy, or persistent renal dysfunction or a greater number of days alive and free of delirium and coma. Randomized trials are needed to inform the choice of antibiotics for empiric treatment infection in critically ill adults.
Influence of printing-based factors on the mechanical properties of hexagonal lattice-structured 3D printed novel walnut shell/polylactic acid composite
Authors: Mathiazhagan N , Sivakumar Narain Kumar , Palaniyappan Sabarinathan , Rahaman Mostafizur
Published: June 2023

The incorporation of bio-based natural fillers and lattice structures in thermoplastic polymer has superior advantages such as a reduction in the usage of conventional polymers with improved damping and mechanical properties. The present work focuses on the development of Walnut Shell/PLA (WSP) lattice-structured composite by the Fused Filament Fabrication technique. The flexural strength, compression strength, and thickness error properties of the hexagon lattice-structured WSP composites are optimized by varying Printing-Based Factors (PBFs) which include infill density (60%, 80%, and 100%), nozzle temperature (190°C, 210°C, and 230°C), printing speed (10 mm/sec, 20 mm/sec, and 30 mm/sec), and layer height (0.1 mm, .2 mm, and .3 mm). The flexural and compression test experiments were conducted as per the ASTM D790 and ASTM D695 standards. The process optimization of the measured responses is made by using Taguchi grey relational grade optimization technique. The experimental outcomes such as compressive and flexural strength and minimal dimensional error are converted into the Grey Relational Grade (GRG) for the optimization process. The results show that the Signal-to-Noise ratio (S/N) from the measured GRG clearly shows that, the lower layer height of 0.1 mm, higher nozzle temperature of 230°C, higher infill density of 100%, and average printing speed of 20 mm/sec is an optimal experimental condition for attaining higher strengths and lower errors. From the Analysis of Variance (ANOVA) analysis, the printing temperature, and layer height are the most persuasive PBFs for the mechanical and physical characteristics with respect to the incorporated lattice structure. The optimized experimental conditions develop maximum flexural and compressive strengths of 4.98 MPa and 28.19 MPa, in addition to a lower thickness error of .186 mm obtained for hexagon lattice-structured WSP biopolymeric composites.
Impact evaluation of different network planning concepts on traffic noise
Authors: Yuan Minmin , Wu Zhipeng , Wang Haibo , Chen Jincai
Published: June 2023

The purpose of this paper is to study the impact of road structure on traffic noise from an urban network planning perspective, to provide solutions to control and prevent traffic noise at source. The process is divided into three parts. Firstly, the stochastic user equilibrium model for traffic flow allocation is improved to be more accurate. Secondly, a global traffic noise simulation method is proposed for the network based on the noise prediction model, and the noise data is visualized. Finally, a noise evaluation system is established to study the traffic noise evolution patterns under different road structures. The results show that with the increase of network density, the traffic noise value of the network decreases. The layout of one-way roads will reduce the regional traffic noise value. The impact of road grade adjustments on traffic noise is positively correlated with the rate of change in road capacity. The study can provide an effective basis for control traffic noise from the network planning stage.
Knowledge Coupling and Organizational Resilience: The Moderating Effect of Market Orientation
Authors: Wu Dong , Liu Tanfei , Yang Wen , Cui Xinyuan
Published: June 2023

This study conducts an empirical study on the relationship between knowledge coupling and organizational resilience based on the knowledge-based view. Meanwhile, market orientation is considered a moderating variable because of its role in this transmission mechanism. The hypotheses are tested through a survey of 359 Chinese manufacturing firms. The results show that both complementary knowledge coupling and substitutive knowledge coupling have significant positive impacts on organizational resilience, and the proactive market orientation positively moderates the relationship between complementary/substitutive knowledge coupling and organizational resilience, while the responsive market orientation negatively moderates the relationship between complementary knowledge coupling and organizational resilience. In the context of the current globalization of the COVID-19 epidemic, this study explores the critical factors needed to survive and develop by firms in adversity, which enriches the research on organizational resilience and market orientation theory and provides suggestions for firms’ strategic planning.
Assessment of Scheduling Method,Appointment Delay, and No-show Rate in the Ultrasound Unit of a Nigerian Teaching Hospital
Authors: Idigo F. U. , Chijioke N. I. K. , Anakwue A. C. , Nwogu U. B. , Maduka B. U.
Published: June 2023

Increasing incidence of no-shows has been identified as a major challenge to planning of appointment schedules which imparts negatively on revenue generation and system efficiency. This cross-sectional study analysed the scheduling method in use, appointment delay time, appointment compliance rate and no-show rate of patients in the ultrasound unit of a Nigerian tertiary hospital, using observation, patient records and questionnaires. Information obtained were: The time interval between clinician request and examination appointment schedule, patient load distribution, scheduling method, number of patients scheduled and number that kept to appointment scheduling, and as well staff opinion on reasons for patients’ length of stay for ultrasound investigations.

The results showed that the single-block scheduling method was used and patients’ arrival was highest between 7:12 and 9:00 hours with decreasing rate as the day progresses. The time interval between request and appointment was 12–14 days. Appointment compliance rate was observed to be 5.5, while no show rate was 4.5. Poor state of ultrasound machines was observed to be the highest contributing factor to patient delays with Kendall’s coefficient of concordance 0.466.

The findings of this work can be utilized in efficient planning of public hospital ultrasound units to enhance patient access.
Trade Destruction and Trade Diversion of Indian Anti-dumping Duties Against Bangladesh
Authors: Bhuyan Md Iqbal , Oh Keunyeob
Published: June 2023

In this study, we investigate Indian anti-dumping (AD) duties imposed on eight products (Harmonized System classification) from Bangladesh over the period 1998–2020. Using the Poisson pseudo-maximum likelihood method, panel regression analysis is applied to examine the relationship between Indian AD duties and goods imported from Bangladesh. Our results provide weakly suggestive significant evidence of trade destruction in the full sample, though statistical significance is enhanced for all product groups other than lead-acid batteries at the product-level investigation. We also provide suggestive evidence for trade diversion from AD duties. Overall, our results show Indian AD duties to be correlated with a decrease in imports from Bangladesh, and an increase in imports of goods from other, unnamed countries. This suggests that India’s protectionist measures may have been ineffective in protecting local producers, as any adverse effects of protectionism on Bangladesh may be offset by import diversion to other foreign suppliers. We also discuss the policy implications of these findings.
A model of care for attention deficit and hyperactivity disorder among adults in the community
Authors: Suetani Shuichi , Hull Jaimie , Zeniou Lakis , Chong Leshay , Stimming Andrea , Nelson Carmel , Panagoda Gaj
Published: June 2023

Objective

To describe the process of collaborative, contextualised development and implementation of a model of care for adults with symptoms suggestive of attention deficit and hyperactivity disorder in an Aboriginal community-controlled health service.

Conclusion

The current article describes an attempt to reduce unmet mental health needs through a systemic approach within a well-established Indigenous community-controlled organisation.