bluuebunny/crossref_metadata_2025 huggingface dataset:
Correction: van Veelen et al. First-in-Human Drug-Eluting Balloon Treatment of Vulnerable Lipid-Rich Plaques: Rationale and Design of the DEBuT-LRP Study. J. Clin. Med. 2023, 12, 5807
Authors: van Veelen Anna , Küçük I. Tarik , Fuentes Federico H. , Kahsay Yirga , Garcia-Garcia Hector M. , Delewi Ronak , Beijk Marcel A. M. , den Hartog Alexander W. , Grundeken Maik J. , Vis M. Marije , Henriques José P. S. , Claessen Bimmer E. P. M.
Published: March 2024

In the original publication [...]
Co-Morbidities of Irritable Bowel Syndrome in a Racially and Ethnically Diverse Population
Authors: Lee Christina , Rao Supriya , Cabral Howard J. , Weber Horst Christian
Published: March 2024

Introduction: Irritable bowel syndrome (IBS) is a disorder of gut–brain interaction (DGBI), and associated co-morbidities worsen quality of life. Research concerning IBS co-morbidities in different racial/ethnic groups is very sparse. This study aimed to determine the prevalence rates of co-morbidities and possible differences in a multiracial/ethnic IBS cohort. Methods: Based on ICD-9-coded IBS diagnosis, 740 outpatients (≥18 years) were included in this retrospective study at Boston Medical Center. Demographics and ICD-9-coded co-morbidities were extracted from electronic records. Descriptive statistics and multiple logistic regression were used for data analyses. Results: The most prevalent co-morbidities in this IBS cohort included gastroesophageal reflux disorder (GERD) (30%), depression (27%), anxiety (23%), (chronic obstructive pulmonary disease) COPD/asthma (16%), and obesity (10%). GERD was more prevalent in Hispanics and Blacks (p = 0.0005), and non-ulcer dyspepsia (NUD) was more prevalent in Blacks and Asians (p = 0.003). Higher rates of diabetes mellitus type 2 (DMT2) (p = 0.0003) and depression (p = 0.03), but not anxiety (p = 0.9), were present in Blacks and Hispanics. GERD was significantly associated with Hispanics (p = 0.003), dependent on age, overweight, and obesity. NUD was significantly associated with Blacks (p = 0.01) and Asians (p = 0.006), independent of sex, age, and BMI. Cancer of the thyroid, ovaries, and testis occurred at a five-fold higher rate than expected. Conclusions: Significant racial/ethnic differences exist for IBS co-morbidities in this study cohort, including depression, DMT2, GERD, and NUD. Certain cancers were found to be more frequent in this IBS sample as compared with the general population.
CMOS Design of Chaotic Systems Using Biquadratic OTA-C Filters
Authors: Juarez-Mendoza Eduardo , del Angel-Diaz Francisco Asahel , Diaz-Sanchez Alejandro , Tlelo-Cuautle Esteban
Published: March 2024

This manuscript shows the CMOS design of Lorenz systems using operational transconductance amplifiers (OTAs). Two Lorenz systems are then synchronized in a master–slave topology and used to implement a CMOS secure communication system. The contribution is devoted to the correct design of first- and second-order OTA-C filters, using 180 nm CMOS technology, to guarantee chaotic behavior. First, Simulink is used to simulate a secure communication system using two Lorenz systems connected in a master–slave topology, which is tested using sinusoidal signals that are masked by chaotic signals. Second, the Lorenz systems are scaled to have amplitudes of the state variables below 1 Volt, to allow for CMOS design using OTA-C filters. The transconductances of the OTAs are tuned to accomplish a Laplace transfer function. In this manner, this work highlights the design of a second-order CMOS OTA-C filter, whose damping factor is tuned to generate appropriate chaotic behavior. Finally, chaotic masking is performed by designing a whole CMOS secure communication system by using OTA-C based Lorenz systems, and its SPICE simulation results show its appropriateness for hardware security applications.
Restoring Soil Fertility, Productivity and Biodiversity through Participatory Agroforestry: Evidence from Madhupur Sal Forest, Bangladesh
Authors: Islam Kazi Kamrul , Saifullah Md. , Mahboob M. Golam , Jewel Kazi Noor-E-Alam , Ashraf S. M. Kamran , Hyakumura Kimihiko
Published: March 2024

Species diversity and soil quality are deteriorating due to continuous disturbances in ecosystems caused by human interference. However, agroforestry is considered a good approach to minimizing environmental problems. Therefore, the objective of this study was to determine the impacts of participatory agroforestry on restoring soil fertility, farm productivity and biodiversity in the degraded Madhupur Sal forest of Bangladesh. The study purposefully selected 40 common agroforestry programs in Madhupur Sal forest for the collection of soil and plant data from 2020 to 2023. Agroforestry programs have improved soil organic matter, soil carbon, pH, and available N, P and K content to a substantial degree and protected soil degradation, enhancing yield. The soil improvement index represents the potentiality of agroforestry in restoring soil nutrients and carbon in the form of organic matter, which is an important indicator for carbon sequestration and mitigating the impacts of climate change. The resultant cost–benefit and land equivalent ratios were steadily higher, which corroborates the greater productivity and profitability of agroforestry compared to monoculture systems. In contrast, agroforestry restored 31 plant species, opening up opportunities for restoring plant species in the threatened forest ecosystem. Therefore, this study recommended selecting appropriate site-specific species for managing agroforestry and restoring ecosystems.
Effects of Big Data on PM2.5: A Study Based on Double Machine Learning
Authors: Wei Xinyu , Cheng Mingwang , Duan Kaifeng , Kong Xiangxing
Published: March 2024

The critical role of high-quality urban development and scientific land use in leveraging big data for air quality enhancement is paramount. The application of machine learning for causal inferences in research related to big data development and air pollution presents considerable potential. This study employs a double machine learning model to explore the impact of big data development on the PM2.5 concentration in 277 prefecture-level cities across China. This analysis is grounded in the quasi-natural experiment named the National Big Data Comprehensive Pilot Zone. The findings reveal a significant inverse relationship between big data development and PM2.5 levels, with a correlation coefficient of −0.0149, a result consistently supported by various robustness checks. Further mechanism analyses elucidate that big data development markedly diminishes PM2.5 levels through the avenues of enhanced urban development and land use planning. The examination of heterogeneity underscores big data’s suppressive effect on PM2.5 levels across central, eastern, and western regions, as well as in both resource-dependent and non-resource-dependent cities, albeit with varying degrees of significance. This study offers policy recommendations for the formulation and execution of big data policies, emphasizing the importance of acknowledging local variances and the structural nuances of urban economies.
Angioleiomyoma: An Update with a 142-Case Series
Authors: Bernard Mathilde , Le Nail Louis-Romée , de Pinieux Gonzague , Samargandi Ramy
Published: March 2024

Angioleiomyomas are uncommon, noncancerous, smooth muscle tumors that primarily arise from blood vessels. Previous studies have yielded limited data due to the lack of interdisciplinary approaches or restricted patient pools. This study aims to provide a comprehensive analysis of angioleiomyomas, including the demographic, clinical, radiological, and histopathological features, with a large number of patients. Conducted as a retrospective investigation at a single center from January 2005 to June 2023, this study involved 142 patients. Relevant information was extracted from electronic medical records, covering clinical, radiological, histological, and demographic details. Angioleiomyomas mostly occurred at age 59 (1–87), predominately affect females (53%) and commonly arise in subcutaneous tissue (85%) and the lower limbs (76%). MRI findings revealed characteristic signals, with a high prevalence of the solid histologic type (65%), often displaying a reticular sign. Smooth muscle Actin was universally present (n = 95/95), while Desmin and Caldesmon showed positive expression in 83% (n = 71/85) and 98% (n = 92/94) of cases, respectively. This study presents an updated and comprehensive analysis of angioleiomyomas. Typically appearing as well-defined nodules in the extremities, these tumors can be effectively diagnosed using MRI, though histopathological analysis is generally essential for confirmation. Treatment primarily involves straightforward excision, with notable low complication and recurrence rates.
On the Geometry and Topology of Discrete Groups: An Overview
Authors: Grimaldi Renata
Published: March 2024

In this paper, we provide a brief introduction to the main notions of geometric group theory and of asymptotic topology of finitely generated groups. We will start by presenting the basis of discrete groups and of the topology at infinity, then we will state some of the main theorems in these fields. Our aim is to give a sample of how the presence of a group action may affect the geometry of the underlying space and how in many cases topological methods may help the determine solutions of algebraic problems which may appear unrelated.
Membranes and Synaptosomes Used to Investigate Synaptic GABAergic Currents in Epileptic Patients
Authors: Gaeta Alessandro , Lissner Lilian Juliana , Alfano Veronica , Cifelli Pierangelo , Morano Alessandra , Roseti Cristina , Di Iacovo Angela , Aronica Eleonora , Palma Eleonora , Ruffolo Gabriele
Published: March 2024

Among the most prevalent neurological disorders, epilepsy affects about 1% of the population worldwide. We previously found, using human epileptic tissues, that GABAergic neurotransmission impairment is a key mechanism that drives the pathological phenomena that ultimately lead to generation and recurrence of seizures. Using both a “microtransplantation technique” and synaptosomes preparations from drug-resistant temporal lobe epilepsies (TLEs), we used the technique of two-electrode voltage clamp to record GABA-evoked currents, focusing selectively on the synaptic “fast inhibition” mediated by low-affinity GABAA receptors. Here, we report that the use-dependent GABA current desensitization (i.e., GABA rundown, which is evoked by applying to the cells consecutive pulses of GABA, at high concentration), which is a distinguishing mark of TLE, is mainly dependent on a dysfunction that affects synaptic GABAA receptors. In addition, using the same approaches, we recorded a depolarized GABA reversal potential in synaptosomes samples from the human epileptic subicula of TLE patients. These results, which confirm previous experiments using total membranes, suggest an altered chloride homeostasis in the synaptic area. Finally, the lack of a Zn2+ block of GABA-evoked currents using the synaptosomes supports the enrichment of “synaptic fast inhibitory” GABAA receptors in this preparation. Altogether, our findings suggest a pathophysiological role of low-affinity GABAA receptors at the synapse, especially during the fast and repetitive GABA release underlying recurrent seizures.
Joint Modeling and Operational Optimization of a Reverse Osmosis–Mechanical Vapor Recompression System for Coal-Fired Power Plant Wastewater
Authors: Xie Fengling , Zhao Yan , Jiang Aipeng , Zhao Rui , Li Chuang , Wang Jian
Published: March 2024

The operation of coal-fired power plants generates a large amount of wastewater. With the issuance of increasingly strict drainage standards, the cost of wastewater treatment is increasing, and the need to reduce the cost of wastewater treatment is becoming increasingly urgent. Thus, based on the principles of reverse osmosis (RO) and mechanical vapor recompression (MVR) in wastewater treatment, the operational optimization of an RO-MVR joint system was studied in this work with the consideration of reducing the operating costs of wastewater treatment under given operational conditions. Firstly, based on the basic principles of RO and MVR, corresponding mechanism models were established and their accuracy was verified. Then, an economic model of the RO-MVR joint system was established, with the goal of minimizing the water production unit price and daily operating costs of the joint system for optimization analysis. Finally, we analyzed the cost and water production performance of the RO-MVR joint system before and after optimization under different operating conditions. The results show that this optimization based on the RO-MVR joint system will reduce the unit price of water production to 3.16 CNY/m3, with the daily operating costs being decreased by 22% compared to before optimization. This result helps to reduce the cost of zero-discharge wastewater treatment in coal-fired power plants.
Advances in Understanding of Unit Operations in Non-Ferrous Extractive Metallurgy in 2023
Authors: Stopic Srecko , Friedrich Bernd
Published: March 2024

Metallic materials play a vital role in the economic life of modern societies; hence, research contributions are sought on fresh developments that enhance our understanding of the fundamental aspects of the relationships between processing, properties, and microstructures. Disciplines in the metallurgical field ranging from processing, mechanical behavior, phase transitions, microstructural evolution, and nanostructures, as well as unique metallic properties, inspire general and scholarly interest among the scientific community. Three of the most important elements are included in unit operations in non-ferrous extractive metallurgy: (1) hydrometallurgy (leaching under atmospheric and high-pressure conditions, mixing of a solution with a gas and mechanical parts, neutralization of a solution, precipitation and cementation of metals from a solution aiming at purification, and compound productions during crystallization), (2) pyrometallurgy (roasting, smelting, and refining), and (3) electrometallurgy (aqueous electrolysis and molten salt electrolysis). Advances in our understanding of unit operations in non-ferrous extractive metallurgy are required to develop new research strategies for the treatment of primary and secondary materials and their application in industry.
Fatigue and Impact Behavior of Friction Stir Processed Dual-Phase (DP600) Steel Sheets
Authors: Yilmaz Mumin , Ozturk Yilmaz Imren , Saray Onur
Published: March 2024

This study investigates the impact of friction stir processing (FSP) on the deformation behavior of 1.1 mm-thick DP600 steel sheets under both static and dynamic loading scenarios, with a focus on the automotive applications of the material. During the process, the large plastic shear strains imposed by FSP resulted in a maximum temperature of 915 °C, leading to a morphological transformation of the martensite phase from well-dispersed fine particles into lath martensite and grain refinement of the ferrite phase. DP600 steel showed an almost two-fold increase in static strength parameters such as the hardness value, yield strength, and ultimate tensile strength. As-received and processed DP600 steel exhibited a plastic deformation behavior governed by strain hardening. However, uniform elongation and elongation to failure after FSP took lower values compared to those of the as-received counterpart. Following the improvement in the static strength of the steel, the fatigue strength of the steel increased from 360 MPa to 440 MPa after the FSP. The finite-life fatigue fracture surfaces of the as-received samples were characterized by the formation of fine bulges due to the variation in the crack propagation path in the vicinity of the martensite particles/clusters. After FSP, the transformation of the martensite particles into coarser lath martensite also transformed the fracture surface into a step-like morphology. The microstructural evolution after FSP caused a decrease in the absorbed impact energy and maximum striker reaction force from 239 J and 37.6 kN down to 183 J and 33.6 kN, respectively. However, the energy absorption capacity of the processed steel up to failure was higher than the absorbed energy value of the as-received steel at the same impact displacement. The simultaneous decrease in both impact energy and reaction force is attributed to the higher cracking tendency of the processed microstructure due to the lower volume fraction of the ferrite phase. The experimental results reported in this study mainly show that FSP is an easy-to-apply and functional solution to significantly improve the static and cyclic strength of DP600 steel. However, it is clear that the reduced total impact energy absorption capacity after FSP may be taken into account in design strategies.
Wildlife as Food and Medicine in Brazil: A Neglected Zoonotic Risk?
Authors: Zeppelini Caio Graco , Carneiro Ianei de Oliveira , Mascarenhas de Abreu Poliana , Linder Ann Katelynn , Alves Romulo Romeu Nóbrega , Costa Federico
Published: March 2024

The practice of consuming wild fauna in Brazil is both culturally and socioeconomically questionable. Wild animals and their byproducts are sought for nutritional, medicinal, and/or supernatural reasons, with some taxa (e.g., songbirds) being kept as pets. This practice is concentrated in traditional and rural communities, as well as the rural exodus populations in large urban centers, maintained both by cultural preferences and for their role in food safety in part of the rural exodus community. A total of 564 taxa are known to be sold in wet markets in Brazil, with birds, fish, and mammals being the most commonly listed. There is great zoonotic outbreak potential in this consumption chain given the diversity of species involved (with several listed being known reservoirs of zoonotic pathogens), invasion of wild environments for hunting, unsanitary processing of carcasses, and consumption of most/all biotopes of the animal, as well as the creation of favorable conditions to cross-species pathogen transmission. Given its socioeconomic situation and the global trends in disease emergence, there is a risk of the future emergence of a Public Health Emergency of International Concern in Brazil through wildlife consumption.
Unraveling the Role of AtSRT2 in Energy Metabolism, Stress Responses, and Gene Expression during Osmotic Stress in Arabidopsis thaliana
Authors: Obrecht Alberto , Paneque Manuel
Published: March 2024

Sirtuins participate in chromatin remodeling and gene expression regulation during stress responses. They are the only deacetylases that couple the cellular NAD+-dependent energy metabolism with transcriptional regulation. They catalyze the production of nicotinamide, inhibiting sirtuin 2 (SIR2) activity in vivo. The SIR2 homolog, AtSRT2, deacetylates non-histone proteins associated with mitochondrial energy metabolism. To date, AtSRT2 mechanisms during stress responses in Arabidopsis thaliana remain unclear. The transduction of mitochondrial metabolic signals links the energy status to transcriptional regulation, growth, and stress responses. These signals induce changes by regulating nuclear gene expression. The present study aimed to determine the role of SRT2 and its product nicotinamide in the development of A. thaliana and the expression of osmotic stress-response genes. Leaf development was greater in srt2+ plants than in the wild type, indicating that SET2 plays a role in energy metabolism. Treatment with polyethylene glycol activated and inhibited gene expression in srt2- and srt2+ lines, respectively. Therefore, we concluded that SRT2-stimulated plant growth and repressed signaling are associated with osmotic stress.
Unveiling the Genetic Tapestry: Exploring Rhizoctonia solani AG-3 Anastomosis Groups in Potato Crops across Borders
Authors: Naqvi Syed Atif Hasan , Abbas Aqleem , Farhan Muhammad , Kiran Rafia , Hassan Zeshan , Mehmood Yasir , Ali Amjad , Ahmed Niaz , Hassan Muhammad Zeeshan , Alrefaei Abdulwahed Fahad , Ölmez Fatih , Yang Seung-Hwan , Baloch Faheem Shehzad
Published: March 2024

The current study was carried out to screen 10 isolates (ARS-01–ARS-10) of Rhizoctonia. solani from potato tubers cv. Kuroda, which were collected from various potato fields in Multan, Pakistan. The isolates were found to be morphologically identical, as the hyphae exhibit the production of branches at right angles and acute angles often accompanied by septum near the emerging branches. Anastomosis grouping showed that these isolates belonged to AG-3. A pathogenicity test was performed against the susceptible Kuroda variety and among the isolates, ARS-05 exhibited the highest mean severity score of approximately 5.43, followed by ARS-09, which showed a mean severity score of about 3.67, indicating a moderate level of severity. On the lower end of the severity scale, isolates ARS-06 and ARS-07 displayed mean severity scores of approximately 0.53 and 0.57, respectively, suggesting minimal symptom severity. These mean severity scores offer insights into the varying degrees of symptom expression among the different isolates of R. solani under examination. PCoA indicates that the severe isolate causing black scurf on the Kuroda variety was AG-3. A comprehensive analysis of the distribution, genetic variability, and phylogenetic relationships of R. solani anastomosis groups (AGs) related to potato crops across diverse geographic regions was also performed to examine AG prevalence in various countries. AG-3 was identified as the most widespread group, prevalent in Sweden, China, and the USA. AG-5 showed prominence in Sweden and the USA, while AG-2-1 exhibited prevalence in China and Japan. The phylogenetic analysis unveiled two different clades: Clade I comprising AG-3 and Clade II encompassing AG-2, AG-4, and AG-5, further subdivided into three subclades. Although AGs clustered together regardless of origin, their genetic diversity revealed complex evolutionary patterns. The findings pave the way for region-specific disease management strategies to combat R. solani’s impact on potato crops.
Genome-Wide Identification and Co-Expression Networks of WOX Gene Family in Nelumbo nucifera
Authors: Li Juan-juan , Qiu Xiao-yan , Dai Yu-jun , Nyonga Tonny M. , Li Chang-chun
Published: March 2024

WUSCHEL-related homeobox (WOX) genes are a class of plant-specific transcription factors, regulating the development of multiple tissues. However, the genomic characterizations and expression patterns of WOX genes have not been analyzed in lotus. In this study, 15 NnWOX genes were identified based on the well-annotated reference genome of lotus. According to the phylogenetic analysis, the NnWOX genes were clustered into three clades, i.e., ancient clade, intermediate clade, and WUS clade. Except for the conserved homeobox motif, we further found specific motifs of NnWOX genes in different clades and divergence gene structures, suggesting their distinct functions. In addition, two NnWOX genes in the ancient clade have conserved expression patterns and other NnWOX genes exhibit different expression patterns in lotus tissues, suggesting a low level of functional redundancy in lotus WOX genes. Furthermore, we constructed the gene co-expression networks for each NnWOX gene. Based on weighted gene co-expression network analysis (WGCNA), ten NnWOX genes and their co-expressed genes were assigned to the modules that were significantly related to the cotyledon and seed coat. We further performed RT-qPCR experiments, validating the expression levels of ten NnWOX genes in the co-expression networks. Our study reveals comprehensive genomic features of NnWOX genes in lotus, providing a solid basis for further function studies.
Analysis of the UDP-Glucosyltransferase (UGT) Gene Family and Its Functional Involvement in Drought and Salt Stress Tolerance in Phoebe bournei
Authors: Guan Hengfeng , Zhang Yanzi , Li Jingshu , Zhu Zhening , Chang Jiarui , Bakari Almas , Chen Shipin , Zheng Kehui , Cao Shijiang
Published: March 2024

Uridine diphosphate glycosyltransferases (UDP-GTs, UGTs), which are regulated by UGT genes, play a crucial role in glycosylation. In vivo, the activity of UGT genes can affect the availability of metabolites and the rate at which they can be eliminated from the body. UGT genes can exert their regulatory effects through mechanisms such as post-transcriptional modification, substrate subtype specificity, and drug interactions. Phoebe bournei is an economically significant tree species that is endemic to southern China. Despite extensive studies on the UGT gene family in various species, a comprehensive investigation of the UGT family in P. bournei has not been reported. Therefore, we conducted a systematic analysis to identify 156 UGT genes within the entire P. bournei genome, all of which contained the PSPG box. The PbUGT family consists of 14 subfamilies, consistent with Arabidopsis thaliana. We observed varying expression levels of PbUGT genes across different tissues in P. bournei, with the following average expression hierarchy: leaf > stem xylem > stem bark > root xylem > root bark. Covariance analysis revealed stronger covariance between P. bournei and closely related species. In addition, we stressed the seedlings with 10% NaCl and 10% PEG-6000. The PbUGT genes exhibited differential expression under drought and salt stresses, with specific expression patterns observed under each stress condition. Our findings shed light on the transcriptional response of PbUGT factors to drought and salt stresses, thereby establishing a foundation for future investigations into the role of PbUGT transcription factors.
Control of Plant Height and Lateral Root Development via Stu-miR156 Regulation of SPL9 Transcription Factor in Potato
Authors: Luo Hongyu , Yang Jiangwei , Liu Shengyan , Li Shigui , Si Huaijun , Zhang Ning
Published: March 2024

MicroRNAs (miRNAs) are a class of endogenous, non-coding small-molecule RNAs that usually regulate the expression of target genes at the post-transcriptional level. miR156 is one of a class of evolutionarily highly conserved miRNA families. SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factor is one of the target genes that is regulated by miR156. SPL transcription factors are involved in regulating plant growth and development, hormone response, stress response, and photosynthesis. In the present study, transgenic potato plants with overexpressed miR156 were obtained via the Agrobacterium-mediated transformation method. The results showed that the expression levels of the target gene, StSPL9, were all downregulated in the transgenic plants with overexpressed Stu-miR156. Compared with those of the control plants, the plant height and root length of the transgenic plants were significantly decreased, while the number of lateral roots was significantly increased. These results revealed that the miR156/SPLs module was involved in regulating potato plant height and root growth.
Transcriptome Analysis of Meloidogyne javanica and the Role of a C-Type Lectin in Parasitism
Authors: Chi Wenwei , Hu Lili , Li Zhiwen , Lin Borong , Zhuo Kan , Liao Jinling
Published: March 2024

Meloidogyne javanica is one of the most widespread and economically important sedentary endoparasites. In this study, a comparative transcriptome analysis of M. javanica between pre-parasitic second-stage juveniles (Pre-J2) and parasitic juveniles (Par-J3/J4) was conducted. A total of 48,698 unigenes were obtained, of which 18,826 genes showed significant differences in expression (p < 0.05). In the differentially expressed genes (DEGs) from transcriptome data at Par-J3/J4 and Pre-J2, a large number of unigenes were annotated to the C-type lectin (CTL, Mg01965), the cathepsin L-like protease (Mi-cpl-1), the venom allergen-like protein (Mi-mps-1), Map-1 and the cellulase (endo-β-1,4-glucanase). Among seven types of lectins found in the DEGs, there were 10 CTLs. The regulatory roles of Mj-CTL-1, Mj-CTL-2 and Mj-CTL-3 in plant immune responses involved in the parasitism of M. javanica were investigated. The results revealed that Mj-CTL-2 could suppress programmed cell death (PCD) triggered by Gpa2/RBP-1 and inhibit the flg22-stimulated ROS burst. In situ hybridization and developmental expression analyses showed that Mj-CTL-2 was specifically expressed in the subventral gland of M. javanica, and its expression was up-regulated at Pre-J2 of the nematode. In addition, in planta silencing of Mj-CTL-2 substantially increased the plant resistance to M. javanica. Moreover, yeast co-transformation and bimolecular fluorescence complementation assay showed that Mj-CTL-2 specifically interacted with the Solanum lycopersicum catalase, SlCAT2. It was demonstrated that M. javanica could suppress the innate immunity of plants through the peroxide system, thereby promoting parasitism.
Intelligent Sensing, Control and Optimization of Networks
Authors: Wen Guanghui , Fu Junjie , Zhou Jialing
Published: March 2024

The development of many modern critical infrastructures calls for the integration of advanced technologies and algorithms to enhance the performance, efficiency, and reliability of network systems [...]
A Review of Electric UAV Visual Detection and Navigation Technologies for Emergency Rescue Missions
Authors: Tang Peng , Li Jiyun , Sun Hongqiang
Published: March 2024

Sudden disasters often result in significant losses of human lives and property, and emergency rescue is a necessary response to disasters. In recent years, with the development of electric unmanned aerial vehicles (UAVs) and artificial intelligence technology, the combination of these technologies has been gradually applied to emergency rescue missions. However, in the face of the complex working conditions of emergency rescue missions, the application of electric UAV visual detection still faces great challenges, particularly in relation to a lack of GPS positioning signal in closed emergency rescue environments, as well as unforeseen obstacle avoidance and autonomous planning and searching flights. Although the combination of visual detection and visual navigation technology shows great potential and added value for use in the context of emergency rescue, at present it remains in the research and experimental stages. Consequently, this paper summarizes and discusses the current status and development of visual detection and navigation technologies for electric UAVs, as well as issues related to emergency rescue applications, with a view to accelerating the research and application of visual detection and navigation technologies for electric UAVs in emergency rescue missions. In this study, we first summarize the classification of typical disasters, analyze the application of sample UAV and configurations in typical disasters with a high frequency of occurrence, refine key electric UAV technologies in emergency rescue missions, and propose the value of exploring electric UAV visual detection and navigation technologies. Subsequently, current research on electric UAV visual detection and navigation technology is analyzed and its application in emergency rescue missions is discussed. Finally, this paper presents the problems faced in the application of electric UAV visual detection and navigation technology in urban emergency rescue environments and offers insights into future research directions.
Contribuições da educação ambiental crítica para a construção da sustentabilidade: o caso do centro integrado de referência em revitalização da bacia hidrográfica do Baixo São Francisco – Cenir
Authors: Ferreira José Moyses , Pinho Alexandra Moreno
Published: March 2024

O presente trabalho teve como objetivo geral analisar a existência de atividades de difusão e/ou formação em Educação Ambiental no Centro Integrado de Referência em Revitalização da Bacia Hidrográfica do Baixo São Francisco – CENIR – SF. A metodologia utilizada caracteriza-se como qualitativa, por um Estudo de Caso. Para a construção do Marco Teórico, fez-se uma revisão da literatura onde discutiu-se as bases históricas e conceituais da Educação Ambiental (EA) com enfoque na EA critica, em conjunto com a história, função e estruturação do CENIR. Fez-se também uma reflexão sobre as concepções de EA e de meio ambiente, visando ampliar uma proposta de EA crítica. Constata-se que o CENIR não está desempenhando o seu papel, porém tem, e pode ter, na Educação Ambiental formal e não formal da região do Baixo São Francisco um papel muito importante na construção de uma sociedade igualitária e sustentável, capaz de gerar novas racionalidades na relação sociedade-natureza com o combate ao racismo ambiental e promoção da justiça ambiental.
A constelação familiar sistêmica aplicada na mediação e conciliação nos processos civis das Varas de Família
Authors: De Araújo Marine Vitória Pinheiro , Keske Henrique Alexander
Published: March 2024

O presente trabalho tem como objetivo geral analisar a origem da técnica da Constelação familiar, para tratar das possibilidades de sua aplicação na mediação e na conciliação em conflitos familiares nas Varas de Família. Para tal, tem como objetivos específicos: identificar a origem do método; apresentar os elementos que compõem a Constelação Familiar; analisar a mediação e a conciliação no Novo Código de Processo Civil; apresentar as principais contribuições da técnica no âmbito do judiciário; identificar os efeitos positivos da aplicação da técnica nos processos das Varas de Família e apresentar o pensamento sistêmico como novo modo de pensar jurídico. O método empregado diz respeito à análise doutrinária, legal e jurisprudencial.
Calcificações patológicas e os aneurismas da aorta abdominal: o que os exames de imagem nos dizem?
Authors: Do Nascimento Cristian Rodrigues , Mendes Rodrigo , De Oliveira João Gabriel Ferreira , Silva Felipe de Oliveira , Almeida Ludmila de Sousa , Da Fonseca José Honório de Almeida Palma , Tenório Pedro Pereira
Published: March 2024

O Aneurisma de Aorta Abdominal (AAA) é definido como uma dilatação anormal, crônica e focal localizada entre o hiato diafragmático e a bifurcação da artéria ilíaca, quando alcança diâmetro ≥ 30 mm. A porção abdominal da aorta, sobretudo a infrarrenal, é mais suscetível a danos devido a deficiência da vasa vasorum e pela zona de alto estresse hemodinâmico na bifurcação aortoilíaca. Além disso, a instalação de calcificações patológicas pode favorecer o surgimento e progressão dos AAA.  Trata-se de uma revisão bibliográfica que objetivou analisar se a detecção da calcificação patológica da aorta abdominal (CPAA) poderia ser adotada como um recurso no rastreio de potenciais casos de AAA. Foram selecionados estudos que apresentaram diferentes técnicas de diagnóstico por imagem e análise macroscópica do segmento aórtico-abdominal. Percebeu-se que as CPAAs ocorrem em locais com perda da integridade das camadas vasculares, sendo que o estresse gerado por elas apresenta potencial para alterar a homeostase da parede arterial. Diferentes técnicas de diagnóstico podem ser adotadas para a detecção das CPAA, o que poderia servir de estratégia para a identificação de indivíduos com risco aumentado para o surgimento de AAA. A detecção das CPAAs possibilitará uma tomada de decisão precoce pela equipe médica, o que poderia refletir na redução da morbimortalidade decorrente do AAA. Contudo, por hora, não se pode afirmar qual a melhor técnica de diagnóstico, considerando a variabilidade individual e a cronicidade do processo, sendo necessário a realização de mais estudos para tentar estabelecer critérios de escolha quanto à melhor técnica a ser empregada no rastreamento das CPAA.
Monitoria por atividade remota em tempos de pandemia: relato de experiência
Authors: Da Silva Patricia Santos , Araújo Jainara de Souza , Pereira Mauricio das Neves , Cordeiro Dândara Lanara Sousa , Brasil Marcio Davi Barros , Nascimento Valéria Gabriele Caldas , De Souza Arley , Cunha Regina Ribeiro
Published: March 2024

Objetivo: Relatar a experiência da monitoria por atividade remota na atividade curricular Enfermagem Médico-Cirúrgica. Métodos: Trata-se de um estudo descritivo, do tipo relato de experiência, vinculado ao projeto Simulação Realística em Enfermagem Perioperatória da atividade curricular Enfermagem Médico-Cirúrgica, do Curso de Graduação em Enfermagem, da Universidade Federal do Pará. Resultados: Cinco temas foram selecionados para serem desenvolvidos no Laboratório de Ensino I: cateterismo gástrico, cateterismo enteral, cateterismo vesical feminino, cateterismo vesical masculino e avaliação de feridas. Conseguinte a isso, o debate sobre as questões enviadas previamente em formulário permitiu maior participação e interesse dos estudantes sobre o tema abordado. Foram utilizados vídeos pré-selecionados do Youtube que demonstravam o procedimento técnico, os princípios científicos e a segurança do paciente, considerando o contexto pandêmico.  Essas estratégias tiveram boa receptividade, sendo elogiada pelos participantes. Considerações Finais: A monitoria por atividade remota em tempos pandêmicos possibilitou um enfrentamento coletivo, emergindo novas possibilidades e perspectivas para o processo ensino-aprendizagem. Foi evidenciado a necessidade de investimentos no programa de apoio à qualificação do ensino de graduação, visando melhorar a capacidade de aprendizado.
Bloqueio PENG para o manejo da dor em pacientes submetidos a artroplastia total de quadril
Authors: Gonçalves Elielson Felix , Tenório Flávia Luana Lopes , Formiga Antonio Claudio Rocha Mesquita , Coutinho Lucas Bronzeado Cavalcanti , Viana George Baracuhy Cruz , Matias Késia Hadassa Albuquerque , De Farias Arthur José Rodrigues , Silva Arthur Jales , Costa Neto Armando , De Sousa Kassio Melo , Costa Mariana de Melo
Published: March 2024

O número de Artroplastias Totais de Quadril (ATQ) vem sofrendo um aumento expressivo, com cerca de 400.000 realizadas anualmente em todo o mundo. Os pacientes submetidos a ATQ são acompanhados por intenso processo de dor aguda, muitas vezes mal controlada e negligenciada, o que impacta negativamente na qualidade de vida. Nesse sentido, o objetivo desse trabalho foi sumarizar as principais informações a respeito da eficácia do bloqueio PENG quanto ao nível de analgesia proporcionado e demais desfechos pós-operatórios. Foi realizado uma revisão integrativa da literatura, através das plataformas PUBMED e BVS, na qual oito artigos se adequaram aos critérios de inclusão e exclusão, estando divididos em duas categorias principais: eficiência e viabilidade do bloqueio e comparação com outras técnicas. Com base na análise dos artigos selecionados, é evidente que o bloqueio do nervo PENG demonstra eficácia no alívio da dor pós-operatória até 48 horas, oferecendo um potencial efeito poupador de opioides. Além disso, destaca-se uma melhoria na recuperação funcional devido ao bloqueio motor reduzido, evidenciada por uma maior amplitude de movimento no membro afetado, menor tempo para a deambulação inicial e aumento do tempo de caminhada, contribuindo para uma recuperação mais rápida. No entanto, ao comparar o bloqueio PENG com outras técnicas, como a infiltração local de analgésicos e o bloqueio do nervo femoral, a literatura apresenta divergências, variando desde indiferenças até vantagens em termos de manejo da dor, menor consumo de opioides e redução do tempo de estadia hospitalar.
Explorando estratégias de monitoramento do ganho de peso gestacional: insights para o acompanhamento pré-natal
Authors: Gouvêa Clara Michele Madureira Yamim , Costa Lorhainy Suellen , Abreu Raul Ciotti , Figueira Matheus Teperino Percegoni , Sotto-Maior Larissa Rodrigues , Lourenço Amanda Mendes
Published: March 2024

INTRODUÇÃO: O incremento de peso durante a gravidez é uma necessidade fundamental para promover o desenvolvimento saudável do bebê, englobando diversos fatores como o crescimento do feto, placenta, líquido amniótico, além de alterações no corpo materno como aumento do útero, das mamas, volume sanguíneo e acúmulo de reservas de gordura. METODOLOGIA: Revisão narrativa da literatura realizada a partir da busca bibliográfica na base de dados PubMed, com os descritores  “Pregnancy”, “Weight gain”, “Prenatal care”. RESULTADOS: Os estudos pesquisados foram publicados em periódicos internacionais, sendo selecionados artigos de revisão, revisão sistemática e metanálise. DISCUSSÃO: Profissionais de saúde devem oferecer orientações personalizadas para as gestantes, garantindo que o ganho de peso esteja dentro dos limites recomendados ou fazendo ajustes quando necessário. Durante as consultas pré-natais, é possível calcular e discutir a programação do ganho de peso até a próxima visita, o final do trimestre ou o término da gestação, promovendo uma abordagem integrada ao cuidado materno-infantil. CONCLUSÃO: Embora as diretrizes e curvas sejam essenciais, é crucial reconhecer os desafios em sua aplicação, especialmente diante das complexidades físicas e emocionais da gestação. Profissionais de saúde devem abordar as gestantes com empatia e respeito, evitando julgamentos, para incentivar a adesão às recomendações e reduzir os riscos para mãe e bebê.
Artrite Séptica - aspectos fisiopatológicos, epidemiológicos e manejo terapêutico
Authors: Takahashi Jorge Carlos Hideyoshi , Carneiro Carlos André dos Santos , Cintra Guilherme da Silveira , Rudge George Vieira de Mello , Mateus Mayara Carvalho , Anselmo Gabriel Calarge , Da Silveira Igor Boechat Magalhães , Jahn Mariana Lais da Silva , Fusinato Paula Tormen , Lopes Rafaela de Souza
Published: March 2024

A artrite séptica é uma condição inflamatória articular desencadeada por uma infecção bacteriana, fúngica, viral ou por outros patógenos incomuns. O Staphylococcus aureus é o patógeno mais comum, com destaque para o aumento preocupante de isolados resistentes à meticilina (MRSA). Os sintomas incluem dor, inchaço, febre e dificuldade de movimentação na articulação afetada. O diagnóstico precoce é crucial e envolve análise do líquido sinovial, hemoculturas e testes sorológicos. A artrite séptica pode afetar tanto crianças quanto adultos, com diferentes agentes etiológicos predominantes em cada faixa etária. A terapia antimicrobiana empírica é iniciada imediatamente, com posterior ajuste com base nos resultados da cultura. A drenagem articular, por artrocentese ou cirurgia, é essencial para remover o exsudato infectado. Os sintomas locais incluem dor, edema e redução da mobilidade, enquanto os sistêmicos podem incluir febre e toxemia. O diagnóstico diferencial é amplo e inclui várias condições que mimetizam a artrite séptica. O tratamento cirúrgico pode ser necessário em casos graves ou refratários à terapia farmacológica. O prognóstico varia, com taxas de mortalidade hospitalar entre 7% e 15%, sendo influenciado por fatores como idade, estado imunológico e resistência bacteriana. Complicações como dor crônica e perda de função articular podem ocorrer, destacando a importância da intervenção rápida e eficaz para melhorar os resultados clínicos.
Contribuição da nutrição para a prevenção e recuperação da Síndrome do Overtraining em atletas
Authors: Pereira Diego Mattos , Dos Santos Vinicius Teles , Vilela Mateus Medeiros , De Oliveira Talles Matos , Oliveira Daniella Campos , Junior José Kuniyoshi K
Published: March 2024

Objetivo: abordar estratégias nutricionais para otimizar a recuperação muscular, restaurar glicogênio e reduzir fadiga em atletas, visando melhorar a saúde física, imunológica e preparação para futuros treinos e competições. Além dos macronutrientes, a revisão explora micronutrientes e suplementos como vitamina C, D, ômega 3, creatina, colágeno e antioxidantes para fornecer uma visão abrangente e subsidiar estratégias nutricionais. Metodologia: revisão sistemática de literatura, com pesquisa realizada em bases de dados do PubMed e UpToDate, utilizando palavras-chave como "nutrição", "Síndrome do Overtraining", "carboidratos", "proteínas", "fluidos" e termos correlatos. Resultados: A Síndrome do Overtraining (SOT) resulta do desequilíbrio entre treinamento e recuperação em atletas, sendo crucial a nutrição para prevenção e recuperação. A ingestão personalizada de proteínas, carboidratos e hidratação é essencial, enquanto vitaminas, minerais, creatina e ácidos graxos ômega-3 desempenham papéis fundamentais na saúde e resiliência. A sinergia entre colágeno e vitamina C destaca a importância de uma abordagem integrada na nutrição esportiva. Conclusão: A Síndrome do Overtraining requer uma abordagem personalizada e integrativa, destacando a importância da nutrição na prevenção e recuperação. A compreensão da interação entre macronutrientes, micronutrientes e suplementos é essencial para fortalecer os atletas contra o treinamento intenso. Uma abordagem colaborativa entre atletas, treinadores e profissionais da saúde é crucial para maximizar o desempenho atlético e garantir a integridade da saúde a longo prazo.
Doença de Chagas: aspectos socioambientais de uma doença neglienciada e a fisiopatologia da cardiopatia chagásica
Authors: De Castro Arthur Gonçalves , Fernandes Hayla Bertrine Guedes Barbosa
Published: March 2024

Introdução: A Doença de Chagas é uma doença negligenciada devido seu mecanismo de transmissão generalizado em áreas instáveis, causada pelo Trypanosoma cruzi, um protozoário que ao entrar no corpo humano, causa infecção com sintomas sistêmicos inespecíficos e complicações do trato gastrointestinal e do musculo cardíaco. Nesse sentido, este artigo científico utiliza uma revisão integrada da literatura para correlacionar doenças endêmicas em populações de baixa renda com a prevalência e fisiopatologia da cardiopatia chagásica em comunidades marginalizadas. Objetivo: Reconhecer que o aumento no número de casos da Doença de Chagas está diretamente relacionado a questões ambientais. Analisar os motivos que leva essa patologia ser tão proeminente em população miseráveis. E evidenciar elementos e possibilidades de enfrentamento dessa problemática. Metodologia: Trata-se de uma revisão integrativa, retrospectiva, narrativa e de última geração da literatura com o objetivo de identificar perfis de doenças com base em dados secundários. Serão utilizadas como estratégia de pesquisa uma revisão e análise de literatura através das bases de dados SciELO, Google Scholar, BVsalud, PubMed, DATASUS, utilizando as seguintes descrições como citações: doença de Chagas; cardiopatia chagásica; doenças negligenciadas; Trypanosoma cruzi. Considerações finais: Conclui-se que a doença de Chagas é uma doença negligenciada por apresentar indicadores inaceitáveis, dispor de baixos investimentos e representar a marginalização de uma boa parte da população brasileira excluídas dos progressos científicos, incitando o desenvolvimento de sintomas e sinais de insuficiência cardíaca, eventos cardo embólicos, arritmias e anginóides que favorecem a patologia.