bluuebunny/crossref_metadata_2025 huggingface dataset:
Spiders (Araneae) of the northeast of the Luhansk Oblast (Ukraine)
Authors: Polchaninova Nina , Marushchak Oleksii
Published: March 2023

The dataset contains records of spiders collected in the northeast of Luhansk Oblast in the periods 1982-1989, 2009-2011 and 2021. It aimed at the inventory of spider fauna of the Striltsivskyi Steppe Nature Reserve and species distribution in the main grassland and forest habitats of the region. The research was also concerned with the impact of conservation management ‒ hay mowing or strict protection and man-induced steppe fire on spider communities.

The dataset includes records from seven geographical localities in the northeast of Luhansk Oblast with 1,955 occurrences of 6662 individuals. For the first time, it provides detailed information about spider species composition, phenology and habitat distiribution within the study area, including two conservation areas and the primary material on the studies on the impact of hay making and steppe fire on spider communities. All the records of 246 spider species with georeferencing were published in GBIF.
New relevant chorological and conservation data on Carex (Cyperaceae) and Hypericum (Hypericaceae) from Ecuador
Authors: Jiménez-Mejías Pedro , Morales-Alonso Ana , Oleas Nora , Sánchez Enmily , Martín-Bravo Santiago , Masa-Iranzo Irene , S. Meseguer Andrea
Published: March 2023

Knowledge of Carex L. (true sedges) and Hypericum L. (St. John's wort) in the Neotropics is fragmentary.

As a result of a fieldwork campaign in Ecuador and revision of herbarium collections (K, QCA and QCNE), we present here relevant records of twelve Carex (Cyperaceae) and four Hypericum (Hypericaceae) species. Regarding Carex, we present the novel report for South America of C. aztecica, as well as the first Ecuadorian records for C. brehmeri, C. collumanthus, C. fecunda, C. melanocystis and C. punicola. The three later records have additional biogeographical significance, as they represent the new northern limit of these species. We also include observations for another five species included in the Ecuadorian Red List of Endemic Plants. As a result, the list of native Carex reported for Ecuador would now include 52 taxa. With regard to Hypericum, we include the new report of H. sprucei for the province of Bolívar, and the confirmation of the presence of three rare species (H. acostanum, H. matangense, H. prietoi) in their type localities, although with extremely low population sizes. We discuss their conservation status and implications.
A new species of frog (Terrarana, Strabomantidae, Phrynopus) from the Peruvian Andean Grasslands
Authors: Chávez Germán , García-Ayachi Luis A. , Catenazzi Alessandro
Published: March 2023

We describe a new terrestrial frog from the puna grasslands adjacent to the Mantaro dry valley in southern Peru. Phrynopus apumantarumsp. nov. is similar in appearence to P. bufoides but is differentiable by lacking discoidal fold and enlarged warts on dorsum, lacking a prominent post ocular fold and having canthal and post ocular stripe. Lastly, we propose to place the new species under the Vulnerable (VU) category of the IUCN Red List, due its small distribution and habitat loss recorded at the type locality.
The taeniaticornis-group of genus Apanteles Foerster (Hymenoptera, Braconidae, Microgastrinae) from China with one new species
Authors: Liu Zhen , Chen Xue-xin
Published: March 2023

The taeniaticornis-group of genus Apanteles Foerster from China is revised, in which a total of 3 species are recorded and illustrated. One new species, named, A. parectangular Liu & Chen, sp. nov. is described and illustrated, and a key to Chinese species of the taeniaticornis-group, is provided.
A new species of the genus Lindaspio Blake & Maciolek, 1992 (Annelida, Spionidae) from a cold seep near Hainan Island, China
Authors: Sui Jixing , Dong Dong , Wu Xuwen , Li Xinzheng
Published: March 2023

A new species of the spionid genus Lindaspio Blake & Maciolek, 1992 was collected from a cold seep near the Hainan Island at a depth of 1758 m. Morphologically, Lindaspio polybranchiatasp. nov. differs from the congeners in having a narrow, folded caruncle and more neuropodial branchiae (from chaetiger 20). The 18S, COI, and 16S sequences of the new species have been submitted to GenBank. It is the first record of the genus Lindaspio from Chinese waters. A key to all species of Lindaspio is given.
Les psychédéliques, nouvelles perspectives pour les thérapies du traumatisme
Authors: Josse Évelyne , Baliko Christophe , Dubus Zoë
Published: March 2023

Les psychothérapies axées sur le traumatisme sont généralement préconisées comme traitement de première intention pour les TSPT et les antidépresseurs ISRS comme traitement de deuxième ligne. Néanmoins, les taux importants d’abandon en cours de traitement, tant psychothérapeutique que médicamenteux, et le nombre de personnes continuant à souffrir malgré une ou plusieurs tentatives de prise en charge indiquent que l’offre de soins actuelle ne répond pas aux besoins de nombreux patients. En 1971, la Convention sur les substances psychotropes, coordonnée par l’ONU, a classé les psychédéliques dans les substances dangereuses sans réelle valeur thérapeutique. Toutefois, depuis une vingtaine d’années, des centres de recherches obtiennent des dérogations pour mener des essais cliniques. Ces substances ouvrent des perspectives thérapeutiques alternatives prometteuses dans le traitement de troubles de stress post-traumatique sévère. La première étude de phase 3, randomisée, multisite, en double aveugle, contrôlée par placebo, montre une amélioration cliniquement significative des symptômes de TSPT chez 88 % des patients et 67 % ne remplissent plus les conditions requises pour un diagnostic de TSPT. Les PDL réduisent non seulement les symptômes traumatiques, mais favorisent également la croissance post-traumatique. Ces substances se sont aussi montrées efficaces à réduire les troubles du sommeil, l’anxiété sociale, l’addiction à l’alcool et aux drogues et les troubles alimentaires chez les patients souffrant de TSTP. Le degré de l’expérience « mystique » est apparu comme prédicteur de changements à long terme. Les psychédéliques combinés à la psychothérapie présentent des avantages par rapport aux médicaments existants utilisés comme traitement de première intention du TSPT en termes de profil de sécurité et d’effets secondaires, d’efficacité et de durée de rémission. Toutefois, le profil de sécurité des PDL peut varier en fonction du contexte dans lequel ils sont utilisés. Peu d’effets secondaires négatifs durables et d’incidents graves sont signalés, mais des réactions indésirables passagères sont fréquentes. Des cas très rares de trouble persistant des perceptions dû aux hallucinogènes caractérisé par des symptômes perceptifs, principalement visuels, prolongés ou récurrents, sont rapportés, généralement lorsqu’ils sont consommés dans un cadre récréatif. L’expérience vécue sous psychédélique est fortement influencée par la disposition psychologique du sujet et par le cadre dans lequel elle se déroule. Le concept de «set and setting» désigne les paramètres non-médicamenteux de l’expérience qui façonnent la réponse aux substances psychédéliques. La thérapie assistée par psychédéliques débute par quelques entretiens préparatoires, se poursuit par la séance d’administration du psychédélique et continue par des séances d’intégration avec un thérapeute.
Psychothérapie transculturelle. Décentrage et contre-transfert
Authors: Lesœurs Guy , Ferradji Taieb
Published: March 2023

En présence d’un patient, migrant et ou porteur d’une autre culture, le psychothérapeute, quelle que soit sa pratique clinique (analytique, systémique, cognitivo-comportementaliste etc.), en plus de l’indispensable empathie, doit s’adapter à la personne et à son histoire, par une posture authentique et consciente, intégrant la tolérance à la différence culturelle, le respect des croyances sans imposition de ses propres schémas culturels et même… en abandonnant, pour un temps, son savoir de soignant. Ce décentrage de sa propre culture et même de son savoir de thérapeute lui permet de ne pas comparer, de ne pas imposer l’image de soi et de son groupe d’appartenance, afin de ne pas stigmatiser et focaliser sur les carences ou les attributs qu’il peut trouver « exotiques » chez l’autre, étranger à sa propre culture. La posture transculturelle n’est pas donnée d’emblée mais nécessite un apprentissage afin d’établir l’alliance thérapeutique, prérequis à la relation transféro-contre-transférentielle.
Premières leçons de la guerre en Ukraine
Authors: Thiériot Jean-Louis
Published: March 2023

La guerre en Ukraine nous oblige à voir que le monde est plus divisé que jamais. L’Union européenne et l’Otan se doivent de réagir alors même que le référent occidental est remis en cause. Ce nouvel ordre mondial doit inciter la France à retrouver puissance et influence.
La neutralité suisse, victime collatérale de Vladimir Poutine
Authors: Werly Richard
Published: March 2023

La neutralité helvétique est une réalité ancienne qui a permis à Berne d’éviter de devoir prendre parti. Avec la guerre en Ukraine, cette position diplomatique est fragilisée et oblige désormais la Suisse à réfléchir sur une évolution de son statut et à accepter de nouvelles modalités dans sa politique étrangère.
Le Centre de normalisation de défense fête ses vingt ans
Authors: Wencker Michel
Published: March 2023

Les normes fixent notre environnement tant civil que militaire. Ainsi, il appartient au Centre de normalisation de défense de définir et proposer le corpus normatif dont celui fixé par l’Otan ( STANAG ) qui s’impose à nos armées. Le CND participe à coordonner une activité essentielle pour garantir l’efficacité opérationnelle.
Redécouvrir la théorie des jeux
Authors: Namor Anthony
Published: March 2023

L’apport des mathématiques de la décision – la théorie des jeux – contribue directement à la réflexion tactique et stratégique. La modélisation de choix possibles permet une contribution au processus décisionnel du chef militaire, sans pour autant être le seul critère d’appréciation de la situation opérationnelle.
Amérique latine
Authors: Drouhaud Pascal
Published: March 2023

Le Pérou connaît une forte instabilité politique et institutionnelle quasi permanente avec six Présidents depuis 2016. Cette crise nationale a des impacts sociaux mais aussi au niveau régional dans une Amérique latine en forte turbulence, d’autant plus que la crise sanitaire de la Covid-19 y a été dramatique.
The intensity of the cluster drop affects the bioactive compounds and fatty acid composition in hazelnuts
Authors: Karakaya O.
Published: March 2023

This study was conducted to determine how the intensity of the cluster drop effects nut traits, bioactive compounds, and fatty acid composition in Tombul, Palaz and Kalınkara hazelnut cultivars. The cluster drop significantly affected bioactive compounds and fatty acid composition while it did not affect the traits of the nuts. As cluster drop intensity increased, nut traits and bioactive compounds in all cultivars increased. Strong cluster drop intensity determined the highest total phenolics, total flavonoids, and antioxidant activity. Except for the Kalınkara cultivar, a low amount of linoleic acid was detected while high amounts of oleic and stearic acid were determined in slight cluster drop intensity. As cluster drop intensity increased, palmitic acid increased. Principal component analysis showed that the slight and intermediate drop intensity were generally associated with kernel length, oleic, linoleic, stearic, palmitoleic, 11-eicosenoic and arachidic acids. In contrast, strong intensity was associated with nut and kernel weight, kernel ratio, kernel width, kernel thickness, kernel size, bioactive compounds, and palmitic acid. As a result, the bioactive compounds and fatty acid composition, which are important for human health, was significantly affected by cluster drop intensity.
Empirical Rotor Broadband Noise Prediction Using CFD Boundary Layer Parameter Extraction
Authors: Su Jung Yong , Baeder James , He Chengjian
Published: March 2023

In this study, for small unmanned aerial vehicle aeroacoustic predictions, an in-house acoustic code was extended for broadband noise using the empirical Brooks–Pope–Marcolini (BPM) method. The acoustic code was coupled with a comprehensive analysis tool (FLIGHTLAB) or Reynolds-averaged
Navier–Stokes (RANS) method to predict the noise from a DJI 9443 CF rotor. The effects of two input parameters of the BPM method on the broadband noise were investigated, including the effective angle of attack and boundary layer parameters. The empirical formula for the boundary layer
parameters was replaced with predictions using two-dimensional RANS, allowing arbitrary airfoils other than NACA0012. The boundary layer parameters were also predicted using three-dimensional RANS to capture a three-dimensional flow effect, which can be dominant in modern propellers operating
at high rotational speeds. As a result, the three-dimensional effect on the boundary layer was confirmed to conflict with the BPM method, which was developed based on a two-dimensional chordwise flow database. Finally, mid- and high-frequency noise spectra were predicted from the three-dimensional
hybrid RANS/LES simulation to be combined with the BPM results, thus improving the noise spectra predictions at midrange frequencies.
The dissolution of p-methoxycinnamic acid-β-cyclodextrin inclusion complex produced with microwave irradiation
Authors: Isadiartuti Dewi , Ekowati Juni , Rosita Noorma , Amalia Nabella R.
Published: March 2023

ackground: p-methoxycinnamic acid (pMCA) is an ethyl p-methoxycinnamic derivative, which is the largest active ingredient in the rhizome of the kencur (Kaempferia galanga L) plant. Several studies reported that the compound has anti-inflammatory activity but has low solubility in water. The formation of a pMCA-β-cyclodextrin (βCD) inclusion complex with a molar ratio of 1:1 can increase its solubility. The formation of inclusion complexes with conventional methods requires a long time and the yield value is not optimal. Objective: This study aims to evaluate the dissolution of the pMCA-βCD inclusion complex produced using the microwave irradiation method. Methods: The product was manufactured with chloroform solvent and a power of 400 watts (power 80%). It was then evaluated using the Differential Thermal Analysis (DTA) every 2 minutes until the 8th minute. The reaction was complete after 4 minutes of treatment with a yield of 96.5%. The obtained inclusion complexes were evaluated using DTA, FTIR, and PXRD. Subsequently, a dissolution test was carried out using a type 2 apparatus in distilled water medium of pH 6.8±0.05 at 37±0.5°C. Results: The results showed that there was a change in the melting temperature profile, infrared spectra, and crystallinity of the product. An 89.18% dissolution was also obtained within 60 minutes, which was twice that of pMCA compounds. Conclusion: From the results of the study, it can be concluded that the formation of pMCA-βCD inclusion complexes using the microwave irradiation method is capable of providing high-yield values in a short time.
Relationship between knowledge and adherence to hypertension treatment
Authors: Pristianty Liza , Hingis Elsa S. , Priyandani Yuni , Rahem Abdul
Published: March 2023

Background: Hypertension is a continuous increase in arterial blood pressure. About 50-70% of patients do not comply with hypertension treatment. Adherence is a health behavior that can be influenced by several factors, including knowledge. Objective: This study aimed to analyze the relationship between patients’ knowledge and adherence to hypertension medication at the Tanggulangin Primary Healthcare Center, Sidoarjo City. Methods: The research method was analytic-observational with a cross-sectional design. Sixty-five sampled patients participated in this study after meeting inclusion criteria: at the age of over 18 years, having the ability to read and write, and signing the consent forms. The respondents were selected through purposive sampling. Data were analyzed descriptively with the Spearman Rho test to identify a correlation between knowledge and adherence to medication. Results: Patients’ knowledge was mostly categorized as good (60%), followed by moderate category (40%). In addition, adherence to medication was all in the moderate category (100%). The correlation test results show a weak relationship between knowledge and adherence to medication (P=0.007; R=-0,331). Conclusion: Patients’ knowledge is related to adherence to hypertension treatment.
Antiosteoarthritis activities of 70% ethanol extract of Eleutherine bulbosa (mill.) urb. bulb on rats monosodium iodoacetate-induced osteoarthritis
Authors: Sari Riza A. , Luthfiana Fina , Sholihah Irawati , Matsunami Katsuyoshi , Sukardiman Sukardiman , Widyowati Retno
Published: March 2023

Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, Eleutherine bulbosa bulb from Pasuruan, East Java, is used to treat many diseases, also as an anti-inflammatory. Objective: In this research, we employed an in vivo model to examine the effects of 70% ethanol extracts of E. bulbosa (EBE) on the progression and development of OA. Methods: A singular intraarticular injection of Monosodium Iodoacetate (MIA) was used to create the OA model in rats. The progression of OA was observed for three weeks. Furthermore, treatment of EBE at a dose of 6, 12, and 24 mg/200g BW orally for four weeks was conducted to assess the effects on decreasing IL- 1ß level, joint swelling, and hyperalgesia. Results: Induction was successful, indicated by a significant difference (P0.05) in decreasing latency time, increasing joint swelling, and IL-1ß level. EBE 24 mg/200 g BW treatment has significantly (P0.05) reduced IL-1ß levels, joint swelling, and response to hyperalgesia. Conclusion: The 70% ethanol extract of E. bulbosa bulb has therapeutic effects on inflammation through reducing IL-1ß in experimental MIA-induced osteoarthritis in a rat model. According to this study, EBE may have an effective potential new agent for OA therapy.
In vivo anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol
Authors: Rudyanto Marcellino , Ekowati Juni , Widiandani Tri , Syahrani Achmad
Published: March 2023

Background: Indonesia is the world’s primary producer of clove. In order to find new utilization for clove and new biologically active compounds, eugenol, the main constituent of clove, has been converted to its derivatives. Objective: This study aims to examine in vivo anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol. Methods: Fibrosarcoma was induced by injection of benzo(a)pyrene solution. The test compounds were given per oral at 20, 40, and 80 mg/Kg body weight, once a day for 30 days. Results: As a result, all the tested compounds showed activity in reducing the cancer incidence rate. All the tested compounds were also found to reduce tumor weight. Benzoxazine derivatives gave slightly better activity compared to aminomethyl derivatives. The strongest activity was exhibited by 6-allyl-3-(furan-2- ylmethyl)-8-methoxy-3,4-dihydro-2H-benzo(e)(1,3)oxazine. Conclusions: All four benzoxazine and aminomethyl compounds derived from eugenol that were tested exhibited anticancer activity in mice fibrosarcoma.
Development of gastro-food allergy model in shrimp allergen extract-induced sensitized mice promotes mast cell degranulation
Authors: Marhaeny Honey D. , Pratama Yusuf A. , Rohmah Lutfiatur , Kasatu Salsabilla M. , Miatmoko Andang , Khotib Junaidi
Published: March 2023

Background: Food allergies have become more common in the last decade. Shrimp is one of the most dominant food allergy triggers in Asian countries, including Indonesia. After ingesting allergens, B cells will produce allergen-specific Immunoglobin E (IgE). In the sensitization period, repeated allergen exposure promotes Mast Cell (MC) degranulation in intestinal tissue and releases several inflammatory mediators, thereby causing hypersensitivity reactions. Shrimp Allergen Extract (SAE) is an immunotherapy and diagnostic agent currently being developed in Indonesia. In this study, we investigated the effect of SAE administration on eliciting an MC immunological response. Methods: Mice were divided into a non-sensitized and sensitized group. The non-sensitized group only received 1 mg of alum (i.p), whereas the sensitized group received 1 mg of alum and 100 μg of SAE on days 0, 7, and 14. Then, both groups were challenged with 400 μg SAE (p.o) on days 21, 22, and 23 following systemic allergic symptom observation. Results: We showed that SAE was able to increase systemic allergic symptoms significantly in the sensitized mice through repeated challenge (1.33±0.21; 1.83±0.17; and 2.00±0.00), compared to non-sensitized mice (0.17±0.17). Moreover, histopathological analysis showed that the SAE administration causes an increase of MC degranulation in the ileum tissue of the sensitized mice (44.43%±0.01), compared to non-sensitized mice (35.45%±0.01) Conclusions: This study found that SAE could induce allergic reactions in mice by influencing critical effector cells, MCs.
Chemoinformatics approach to design and develop vanillin analogs as COX-1 inhibitor
Authors: Norhayati Norhayati , Ekowati Juni , Diyah Nuzul W. , Tejo Bimo A. , Ahmed Samar
Published: March 2023

Background: Coronary Heart Disease (CHD), commonly known as the silent killer, impacted the severity of COVID-19 patients during the pandemic era. Thrombosis or blood clots create the buildup of plaque on the coronary artery walls of the heart, which leads to coronary heart disease. Cyclooxygenase 1 (COX-1) is involved in the production of prostacyclin by systemic arteries; hence, inhibiting the COX-1 enzyme can prevent platelet reactivity mediated by prostacyclin. To obtain good health and well-being, the research of discovery of new drugs for anti-thrombotic still continue. Objective: This study aims to predict the potential of 17 compounds owned by the vanillin analog to COX-1 receptor using in silico. Methods: This research employed a molecular docking analysis using Toshiba hardware and AutoDock Tools version 1.5.7, ChemDraw Professional 16.0, Discovery Studio, UCSF Chimera software, SWISSADME and pKCSM, a native ligand from COX- 1 (PDB ID: 1CQE) was validated. Results: The validation result indicated that the RMSD was 2 Å. The 4-formyl-2-methoxyphenyl benzoate compound had the lowest binding energy in COX-1 inhibition with a value of -7.70 Å. All vanillin derivatives show good intestinal absorption, and the predicted toxicity indicated that they were non-hepatotoxic. All these compounds have the potential to be effective antithrombotic treatments when consumed orally. Conclusion: In comparison to other vanillin derivative compounds, 4-formyl-2-methoxyphenyl benzoate has the lowest binding energy value; hence, this analog can continue to be synthesized and its potential as an antithrombotic agent might be confirmed by in vivo studies.
In silico study of phytochemicals contained in Brucea javanica in inhibiting the InhA enzyme as antituberculosis
Authors: Sulistyowaty Melanny I. , Putra Galih S. , Ekowati Juni , Widiandani Tri , Matsunami Katsuyoshi
Published: March 2023

Background: Currently Mycobacterium tuberculosis is found to be resistant to the treatment of tuberculosis with rifampin and isoniazid (INH) and often stated as multi-drug resistance (MDR). Knowledge and determination of biological properties of plant extracts is a source of drug candidates in various health fields. Therefore, natural products are important in the discovery of new drugs, especially in disease therapy, particularly for tropical dis- eases, tuberculosis. Brucea javanica, known as Buah Makasar, is found in many Asian countries including Indonesia. This plant fruit has a very bitter taste so it cannot be directly consumed and is often used as a traditional medicine to prevent some diseases, especially malaria. There has been no research on the effectiveness of Buah Makasar in tuberculosis. Objective: This study aims to identify compounds contained in Brucea javanica, namely bruceines, bruceosides and yadanzio-sides in inhibiting the InhA enzyme found in the wall of Mycobacterium tuberculosis. Methods: This in-silico study is using Molegro Virtual Docker (MVD) Ver. 5.5. We compared it to the native ligand, namely N-(4- Methylbenzoyl)-4-Benzylpiperidine (code: 4PI) and the reference drug standard, INH. Results: In-silico results show that yadanziosides found in Brucea javanica have the potential to inhibit the InhA enzyme. Bruceoside F (-190.76 Kcal/mol) has the lowest MolDock score among the 27 other compounds. It is also having lower MolDock score than the native ligand 4PI (-120.61 Kcal/mol) and INH (- 54.44 Kcal/mol). Conclusions: Brucea javanica can be considered as source of drug development for againts tuberculosis.
Microscopic and physicochemical evaluation of Ruta angustifolia leaves
Authors: Wahyuni Tutik S. , Khoiriyah Ni’matul , Tumewu Lidya , Ekasari Wiwied , Fuad Achmad , Widyawaruyanti Aty
Published: March 2023

ackground: There are thousands of species of known medicinal plants in the world. Ruta angustifolia L. has been widely used in traditional medication for jaundice and liver disease. Previous studies have shown that R. angustifolia leaves can inhibit the hepatitis C virus in Huhit culture cells, reduce the value of NS3 protein, and possess a synergistic effect in combination with antiviral drugs. Therefore, this plant is potential to be developed as a drug candidate. Characteristics of plants including microscopic, physicochemical properties, and phytochemical profiles are necessary information to ensure the quality of raw material in drug development. Objective: This study was carried out to examine the microscopic and physicochemical including the standardized parameter of R. angustifolia leaves to fulfil the quality raw materials as traditional medicine. Methods: Simplicia of R. angustifolia leaves obtained from Jombang, East Java, were observed under a microscope and determined its physicochemical properties referred to the Materia Medica Indonesia V. The TLC and HPLC profiles of extract were determined as well. Results: Microscopic analysis were conducted by transfection sections and the presence of epidermis cells, palisade, mesophyll with stomata, and Ca-oxalate crystal were found. The standard parameter obtained value of loss of drying, extractive value in water and ethanol, and ash value. The TLC and HPLC profiles of leaves extract demonstrated to contain with flavonoid, terpenoids, and alkaloids. Conclusion: Ruta angustifolia obtained from Jombang, east Java, has a specific character in microscopic analysis. The physicochemical properties analysis of R. angustifolia leaves as a raw material met the requirements according to Materia Medica Indonesia V.
The association between drug therapy problems and blood pressure control of patients with hypertension in public health center setting
Authors: Wijaya Nyoman , Athiyah Umi , Fasich Fasich , Rahem Abdul , Hermansyah Andi
Published: March 2023

Background: Patients with hypertension are at risk of experiencing Drug Therapy Problems (DTPs). However, few have studied the pattern of DTPs in Indonesian public health center (PHC) and how it affected the blood pressure control. Objective: This study aims to identify DTPs and its association to blood pressure control among patients with hypertension in Indonesian PHCs. Methods: A descriptive, observational and cross-sectional study involving 150 selected persistent hypertensive patients was conducted from August to December 2019 in 63 PHCs in Surabaya. A questionnaire asking patients’ experiences during treatment of hypertension was used. Chi-square test was used to analyze the association between DTPs and blood pressure control. Results: The majority of respondents were aged 50-65 (54.7%), female (76%), only half has controlled blood pressure (52.7%) and most of them used three to four medicines at the same time (57.3%). A total 563 DTPs was identified with 15.6% was unnecessary drug use, 11.4% indicated need for additional drug therapy, one-fifth experienced dosage too low (21.5%) and non-adherence (19.2%) and 26% suffered from adverse drug reactions. There was a significant association between number of DTPs and blood pressure control (P0.05). Conclusion: Most patients experienced more than two DTPs and undertook more than three medicines at the same time. There is a significant association between the number of DTPs in hypertensive patient and the blood pressure control.
Synthesis, anti-angiogenic activity and prediction toxicity of (E)-3-(3-methoxyphenyl) propenoic acid
Authors: Ekowati Juni , Nofianti Kholis A. , Yunita Maya N. , Hamid Iwan S. , Dwiningrum Fitria , Ramadhan Darwin R. , Ananda Ghinalya C.
Published: March 2023

Background: Anti-angiogenic medications, one of cancer chemo preventive mechanism were permitted for different cancers. Nevertheless, major primary and secondary resistance obstruct efficacy in several tumor types. Moreover, the improvement of safe and effective NSAIDs for angiogenesis inhibition is complicated, because of their serious toxicity. So, we require improving clinically appropriate strategies to boost efficacy of anti-angiogenic drugs with low risk of toxicity. Objectives: The present study aimed to synthesize the (E)-3- (3-methoxyphenyl)propenoic acid (3MPCA), to determine the anti-angiogenic activity and predict its toxicity. Methods: 3MPCA was obtained by Knoevenagel reaction using microwave irradiation at 400 Watt. The anti-angiogenesis experimental was performed using chorioallantois membrane of embryonated chicken eggs induced by b-FGF. The potency of 3MPCA was verified at dosage 30 and 60 ng and compared with celecoxib 60 ng. Toxicity prediction of 3MPCA was performed by ProTox II online program. Results: The results showed that 3MPCA was achieved in good yield (89%). Anti angogenic activity was showed by endothelial cells growth in neovascular capillaries of new blood vessel of chorioallantois membrane of embryonated chicken eggs. The endothelial cells growth decreased until 41.7-83%. The prediction LD50 was 1772mg/kg. Conclusion: (E)-3-(3-methoxyphenyl)propenoic acid can be obtained through Knovenagel reaction using microwave irradiation and it has potential as anti-angiogenesis inhibitor with low toxicity.
Role of TGF-β Signaling in Coronavirus Disease 2019
Authors: Chen Junzhe , Wu Wenjing , Wang Wenbiao , Tang Ying , Lan Hui-Yao
Published: March 2023

Abstract

Coronavirus disease 2019 (COVID-19) has a broad spectrum of clinical manifestations involving the respiratory, cardiovascular, renal, neuropsychiatric, gastrointestinal, and dermatological systems. Some patients with COVID-19 experience acute infection and post-COVID-19 syndrome. There is increasing evidence that TGF-β signaling plays an important role in the pathogenesis of both acute and chronic COVID-19 infection. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid protein was reported to interact with Smad3, a key downstream mediator of TGF-β signaling, thereby promoting TGF-β1/Smad3 signaling and causing cell death during the acute phase of COVID-19 infection. Because activation of TGF-β/Smad3 signaling has an essential role in multiple organ fibrosis, it is possible that overreactive TGF-β/Smad3 signaling may cause tissue fibrosis in the lung, heart, and kidney after SARS-CoV-2 infection. Thus, not only administration of antiviral drugs and traditional Chinese medicines, but also targeting of TGF-β signaling components, particularly Smad3, with various therapeutic strategies involving OT-101, pirfenidone, and specific Smad3 inhibitors, such as SIS3, may provide novel and specific therapies for COVID-19 patients.
The effect of melatonin on cognitive functions following coronary artery bypass grafting: A triple-blind randomized-controlled trial
Authors: Jouybar Reza , Zohoori Kambiz , Khademi Saeed , Akhlagh Seyed Hedayatallah , Mani Arash , Akhlagh Seyed Amir reza , Asadpour Elham
Published: March 2023

Background:

Cognitive dysfunction presents one of the chief causes of postoperative morbidity. Melatonin as a neurohormone can improve neurocognitive functioning and sleep disorders. We evaluated the effect of melatonin on the postoperative cognitive function of patients undergoing coronary artery bypass grafting (CABG).

Materials and Methods:

A triple-blind randomized-controlled trial was conducted on 66 CABG candidates in Namazee Hospital (Shiraz, Iran). Patients were assigned equally into two groups receiving melatonin 10 mg or a placebo daily for 4 weeks before surgery and 2 days after surgery in the intensive care unit. The Mini-Mental State Examination (MMSE), Tower of London (ToL), and Wechsler Adults Intelligence Scale-Revised (WAIS-R) cognitive function tests were performed in both groups 4 weeks before surgery (time point 1), 2 days after surgery (time point 2), and 6 weeks after initial administration of melatonin (time point 3).

Results:

The mean change score (time point 3-time point 1) differed significantly between the two groups in the MMSE (P ≤ 0.001), ToL total score (P = 0.001), and WAIS-R general IQ (P ≤ 0.001), picture completion (P ≤ 0.001), vocabulary (P = 0.024), and digit span (P = 0.01). On the other hand, no significant differences were detected in the WAIS-R block design, ToL total time delay, ToL total lab, and ToL total result scores.

Conclusion:

The MMSE and WAIS-R tests revealed that melatonin might have prophylactic effects against postoperative cognitive disturbance in patients undergoing elective CABG.
Geometric similarity invariants of Cowen-Douglas operators
Authors: Jiang Chunlan , Ji Kui , Keshari Dinesh
Published: March 2023

In 1978, M. J. Cowen and R.G. Douglas introduced a class of operators

B_n(\Omega)

(known as Cowen-Douglas class of operators) and associated a Hermitian holomorphic vector bundle to such an operator. They gave a complete set of unitary invariants in terms of the curvature and its covariant derivatives. At the same time they asked whether one can use geometric ideas to find a complete set of similarity invariants of Cowen-Douglas operators. We give a partial answer to this question. In this paper, we show that the curvature and the second fundamental form completely determine the similarity orbit of a norm dense class of Cowen-Douglas operators. As an application we show that uncountably many (non-similar) strongly irreducible operators in

B_n(\mathbb{D})

can be constructed from a given operator in

B_1(\mathbb{D})

. We also characterize a class of strongly irreducible weakly homogeneous operators in

B_n(\mathbb{D})

.
Dogodek v mestu Gogi in model nove drame
Authors: Toporišič Tomaž
Published: March 2023

The essay deals with one of the fundamental dilemmas that Slavko Grum’s plays, especially An Event in the Town of Goga, repeatedly raise, and it is connected with their multi-layered, almost paratactic character. It is precisely because of this characteristic that both literary and theatrical history oscillate between labels such as expressionism, decadence, symbolism, modernism, and so on. It attempts to show how the specifics of this new drama and the new concept of theatre and art in general are revealed precisely through the juxtaposition of An Event in the Town of Goga with the aesthetic revolutions of the historical and partly neo-avant-gardes, as well as of the modernism and neo-modernism of the twentieth century. In this way, when read and compared with contemporaries and successors, the (inter)media map of this highly interesting literary work emerges, which, like the Futurist, Dadaist, Absurdist, Surrealist and Expressionist syntheses, problematised the fundamental thematic preoccupation of the twentieth century: the crisis of the new-modern subject in the world proclaimed by Nietzsche with the absence of God. Grum’s oeuvre was thus, like that of the Expressionists and, at the same time, of Kosovel’s dramatic fragments, Mrak’s Obločnica, and Delak’s The Serpent in the Sky’s Dawn, heterogeneous. The various avant-garde tactics that developed simultaneously in European and American modernist drama and prose of the first half of the twentieth century entered into dialogue and interesting relationships with each other, and it is An Event in the Town of Goga that comes closest to some modernist or avant-garde procedures within Grum’s oeuvre.
Application of crowdsourcing in education on the example of eTwinning
Authors: Gajek Elżbieta
Published: March 2023

While eTwinning is focused on facilitating collaboration among schools in Europe and beyond, the extensive participation of over one million teachers from 44 countries makes the program an extensive educational crowdsourcing activity. In this paper the program which structures the related pedagogical approaches and practices will be analyzed and discussed in light of the crowdsourcing principles. Teachers and students participate in the program voluntarily. All collaborative activities, material production and publication of results which take place online and emphasize language learning fulfil the characteristics of the effective use of crowdsourcing in education. Two kinds of analyses are undertaken, a global analysis of the program features and local analysis of the selected projects. The global analysis relates the crowdsourcing practices to the eTwinning activities. The local analysis is based on the outstanding projects submitted for evaluation for national awards in Poland, further exemplified by activities and reference to the public sites of the projects. The aim of the text is to show that teachers may effectively use crowdsourcing in educational practice even when not primarily focused on its application.
EnetCollect – European Network for Combining Language Learning with Crowdsourcing Techniques (COST Action CA16105)
Authors: Nicolas Lionel , Lyding Verena
Published: March 2023

This article reviews the European Network for Combining Language Learning with Crowdsourcing Techniques (enetCollect), an extensive network project created to foster research and innovation (R&I) on the combination of crowdsourcing and language learning. Accordingly, we explain how it began, introduce its overall logic and organization, and discuss its achievements in terms of both (1) creating a new R&I community through a concluded large network project, and (2) fostering R&I on a high-potential and mostly unexplored subject.
We also discuss the challenges involved and lessons learned, whether in orchestrating and leading a new R&I community or the challenges we faced and generally observed in the efforts of enetCollect members, as they explored the many facets of such a versatile enterprise.
Crowdsourcing ratings for single lexical items
Authors: Volodina Elena , Alfter David , Lindström Tiedemann Therese
Published: March 2023

In this study, we investigate theoretical and practical issues connected to differentiating between core and peripheral vocabulary at different levels of linguistic proficiency using statistical approaches combined with crowdsourcing. We also investigate whether crowdsourcing second language learners’ rankings can be used for assigning levels to unseen vocabulary. The study is performed on Swedish single-word items.
The four hypotheses we examine are: (1) there is core vocabulary for each proficiency level, but this is only true until CEFR level B2 (upper-intermediate); (2) core vocabulary shows more systematicity in its behavior and usage, whereas peripheral items have more idiosyncratic behavior; (3) given that we have truly core items (aka anchor items) for each level, we can place any new unseen item in relation to the identified core items by using a series of comparative judgment tasks, this way assigning a “target” level for a previously unseen item; and (4) non-experts will perform on par with experts in a comparative judgment setting. The hypotheses have been largely confirmed: In relation to (1) and (2), our results show that there seems to be some systematicity in core vocabulary for early to mid-levels (A1-B1) while we find less systematicity for higher levels (B2-C1). In relation to (3), we suggest crowdsourcing word rankings using comparative judgment with known anchor words as a method to assign a “target” level to unseen words. With regard to (4), we confirm the previous findings that non-experts, in our case language learners, can be effectively used for the linguistic annotation tasks in a comparative judgment setting.
Fertility capability classification of selected soils on the basement complex of north-eastern Nigeria
Authors: Kefas P.K. , Maniyunda L.M. , Shobayo A.B. , Garjila Y.A. , Philip H.J. , Christopher A.
Published: March 2023

A clear understanding of soil characteristics and their appropriate classification are essential for efficient land use and increased productivity. The present study was carried out to obtain the fertility capability classification (FCC) of the soils overlying the basement complex in a toposequence in north eastern Nigeria and to serve as baseline data for soil management. Soils on four topographic positions identified on porphyritic granite (PG), pegmatite (PT) and granite-gneiss (GG) of the basement complex in Taraba State of Nigeria were assessed. Twelve pedons were studied in all, four along the toposequence on PG, PT, and GG. At the type and substrata type, sandy and loamy group dominated. Ustic soil moisture regime, exchange acidity (fixing available phosphorus) and low organic carbon limited the entire soils across the basement complexes restricting rainfed crop production to one season per annum except with irrigation practice. Poor drainage was a limitation across the soils on pegmatite. The FCC rated PG and GG soils as SLdeam (sand over loam and limited by moisture, effective cation exchange capacity, aluminium toxicity and organic carbon) and Ldam (loam type and substrata characteristics limited by moisture, aluminium toxicity and organic carbon), and PT and PT soils as Sdamg (sandy type and substrata type restricted by moisture, aluminium toxicity, organic carbon, drainage). Ridge construction, organic and mineral fertilizer applications are essential management practices required for sustainable use of these soils.
Comparative assessment of selected micronutrients under three different land use systems in Odighi, Edo State, Nigeria
Authors: Orobator P.O. , Ekpenkhio E. , Ugwa I.K.
Published: March 2023

This study carried out a comparative assessment of selected micronutrients under mixed tree plantation, cassava and secondary forest land use systems in Odighi, Edo State, Nigeria. The objectives of the study were to determine the concentrations of selected micronutrients under each of the three land use systems; evaluate the distribution of these micronutrients among the three land use systems; and examine the impact of the three land use systems on the selected micronutrients. Using transect sampling design, 18 soil samples were collected from each of the three land use systems giving a total of 54 soil samples for the study. The cassava land use was 7-10-year-old, mixed tree plantation was 10-15-year-old, while secondary forest was 25-year-old and above. Results showed that the concentrations of the selected soil micronutrients (iron, copper, manganese, and zinc) increased with increasing soil depth in all the examined sites except for manganese under cassava land use. The status of iron and zinc were rated excess while copper and manganese were rated optimum for crop production. The study observed significant (p < 0.05) variations for iron and manganese contents across the examined land uses and concluded that the direction and magnitude of changes in the status of micronutrients were a reflection of long-term impact of the different land uses and soil management measures. Liming of the soil and limited use of nitrogen-containing fertilizers are recommended to ameliorate zinc toxicity in the study area. Also, farmers in collaboration with agriculture extension workers should regulate the usage of organic and inorganic fertilizers as soil treatments to avoid excessive concentrations of iron and zinc in the study area.
Investment decision and level of investment in marketing of value-added products of yam and cassava in Benue State, Nigeria
Authors: Okeke A.M. , Salami A.O. , Nkemjika F.S.
Published: March 2023

The supply gap of value-added products of yam and cassava in Nigeria has continued to widen and modeling investment in marketing of these products using Double Hurdle model is non-existence in literature. The study thus investigated factors influencing investment decision and level of investment in the marketing of valueadded products of yam and cassava in Benue State, Nigeria, using Double Hurdle model. Data were collected through structured questionnaire from 300 marketers of value-added products of yam and cassava, selected via multi-stage random sampling technique. The collected data were analyzed using descriptive statistics and Double Hurdle model. The results revealed that marketers of these products in the study area were mostly married females with moderate household size, literate, young, non-member of cooperatives, experienced, and had access to credit with akpu/fufu as the most marketed product among the marketers. Estimates of the Double Hurdle model revealed that sex, marital status, age, and membership of cooperatives were the factors influencing investment decision in the marketing of these products while sex, marital status, level of education, age, membership of cooperatives, return, and credit received were the factors influencing level of investment in the marketing of these products. In identifying factors that significantly influence investment decision and level of investment in the marketing of these products, this study provides an empirical contribution to the existing literature. It was recommended that policies geared towards increasing the level of investment in the marketing of these products should take into consideration the socio-economic characteristics of the marketers.
Gum arabic and beeswax as edible coatings for extending the postharvest shelf life of tomato (Lycopersicon esculentum. L) fruit
Authors: Afedzi A. E. K. , Ahadjie V. , Quansah L.
Published: March 2023

Edible coatings can provide an alternative for extending the postharvest shelf life of fresh fruits and vegetables. The effect of two edible coatings and their combinations were studied on some physical qualities of tomato fruits. Gum arabic was formulated from the exudate of Acacia tree, and beeswax was sourced from the Horticulture Department, University for Development Studies. Cassava starch was used as a plasticizer for both materials. Tomato fruits were treated with gum arabic, beeswax, and a combination of the two at concentrations 5, 10, and 15%. Treated and untreated fruits were examined for their weight loss and decay during 20 days of storage and sampling were done at 4 days intervals. Fruits coated with gum arabic alone did not show much positive impact on weight loss and decay when compared to the control fruits. The beeswax alone however showed a positive impact on weight loss and decay. Furthermore, the combination of the beeswax and gum arabic resulted in the highest performance with reduced weight loss of 26.7%, and 13.9% decay after 20 days in storage. Hence, the combination of gum arabic and beeswax could extend the postharvest shelf life of tomato fruits at 29˚C and 72 - 75% temperature and relative humidity, respectively.