bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Characterization of PEGylated Liposomes and Nanostructured Lipid Carriers with Entrapped Bioactive Triterpenoids: Comparative Fingerprints and Quantification by UHPLC-QTOF-ESI+-MS, ATR-FTIR Spectroscopy, and HPLC-DAD
Authors: Socaciu Carmen , Fetea Florinela , Socaciu Mihai Adrian
Published: December 2024

Background/Objectives: Pentacyclic triterpenoids, as bioactive phytochemicals, have proven to exhibit significant bioactivity (antioxidant, anti-inflammatory, hypoglycemic, and anticancer) and low cytotoxicity. This study developed convenient methods for extracting and characterizing a birch bark extract enriched in pentacyclic triterpenoids (betulin, betulinic acid, and lupeol) and entrapped in two bioavailable nanoformulations. The performance of ATR-FTIR spectroscopy as a cost-effective and non-destructive method was evaluated comparatively with accurate HPLC-based methods. Methods: The bark extract and pure betulin or betulinic acid were used to obtain PEGylated liposomes and nano lipid carriers (NLCs). Their size was characterized by light scattering diffraction. UV–Vis spectrometry was applied as a preliminary evaluation (1), as well as UHPLC-QTOF-ESI+-MS for structure identification (2), ATR-FTIR spectroscopy (for semi-quantitative evaluation) (3), and HPLC-DAD for an accurate quantification of each component, either in the organic solvents or in the nanoformulations (4). Results: The PEGylated liposomes had smaller sizes, and higher entrapment efficiency, significantly correlated between the three analytical methods. The performance of ATR-FTIR spectroscopy was positively correlated with HPLC-DAD data and confirmed the potential of this cheaper and reliable semi-quantitative method to evaluate the entrapment efficiency of TTs in liposome and NLC nanoformulations. Conclusions: The results recommend using liposomal nanoformulations for the entrapment of bioactive terpenoids and their characterization by ATR-FTIR after validation by HPLC-DAD. The ATR-FTIR spectroscopy also offers the possibility of screening in a short time different recipes of nanoformulations as well as their stability and bioavailability, which is useful for investigations in vitro and in vivo, which may confirm their efficacy as therapeutic agents.
Therapeutic Efficacy of Lavandula dentata’s Oil and Ethanol Extract in Regulation of the Neuroinflammation, Histopathological Alterations, Oxidative Stress, and Restoring Balance Treg Cells Expressing FoxP3+ in a Rat Model of Epilepsy
Authors: Antar Aziza , Abdel-Rehiem Eman S. , Al-Khalaf Areej A. , Abuelsaad Abdelaziz S. A. , Abdel-Gabbar Mohamed , Shehab Gaber M. G. , Abdel-Aziz Ayman M.
Published: December 2024

Background/Objectives: Despite the availability of antiepileptic drugs (AEDs) that can manage seizures, they often come with cognitive side effects. Furthermore, the role of oxidative stress and neuroinflammatory responses in epilepsy and the limitations of current AEDs necessitate exploring alternative therapeutic options. Medicinal plants, e.g., Lavandula dentata L., are rich in phenolic compounds and may provide neuroprotective and anti-inflammatory benefits. However, limited research evaluates their effectiveness in modulating neuroinflammation and histopathological changes in epilepsy models. Therefore, the current study hypothesized that treating Lavandula dentata L. extract or essential oils may reduce neuroinflammatory responses and mitigate histopathological changes in the brain, providing a natural alternative or adjunct therapy for epilepsy management. Methods: Five groups of male Wistar rats were used: control, pilocarpine-treated epileptic, valproic acid (VPA-treated epileptic), L. dentata extract, and essential oils. Numerous electrolyte levels, monoamine levels, neurotransmitter levels, and the mRNA expression of specific gate channel subtypes were evaluated in homogenate brain tissue. Additionally, histological changes in various brain regions were investigated. Results: The investigation revealed that the extract and essential oils obtained from L. dentata L. exhibited the ability to improve the modulation of electrolytes and ions across voltage- and ligand-gated ion channels. Furthermore, it was revealed that they could decrease neuronal excitability by facilitating repolarization. Moreover, L. dentata’s oil and ethanol extract re-balances T-reg/Th-17 cytokines, restoring the pro/anti-inflammatory cytokines and Treg markers, e.g., FOXP3 and CTLA-4, to their normal level. Conclusions: The present work confirms that the extract and essential oils of L. dentata L. have different activities to ameliorate the progression of histopathological alterations. Therefore, when used in conjunction with other AEDs, the extract and essential oils of L. dentata can slow the progression of epileptogenesis.
Drug-Drug Interactions Between HIV Antivirals and Concomitant Drugs in HIV Patients: What We Know and What We Need to Know
Authors: De Bellis Emanuela , Donnarumma Danilo , Zarrella Adele , Mazzeo Salvatore Maria , Pagano Annarita , Manzo Valentina , Mazza Ines , Sabbatino Francesco , Corbi Graziamaria , Pagliano Pasquale , Filippelli Amelia , Conti Valeria
Published: December 2024

Highly active antiretroviral therapy has led to a significant increase in the life expectancy of people living with HIV. The trade-off is that HIV-infected patients often suffer from comorbidities that require additional treatment, increasing the risk of Drug-Drug Interactions (DDIs), the clinical relevance of which has often not been determined during registration trials of the drugs involved. Therefore, it is important to identify potential clinically relevant DDIs in order to establish the most appropriate therapeutic approaches. This review aims to summarize and analyze data from studies published over the last two decades on DDI-related adverse clinical outcomes involving anti-HIV drugs and those used to treat comorbidities. Several studies have examined the pharmacokinetics and tolerability of different drug combinations. Protease inhibitors, followed by nonnucleoside reverse transcriptase inhibitors and integrase inhibitors have been recognized as the main players in DDIs with antivirals used to control co-infection, such as Hepatitis C virus, or with drugs commonly used to treat HIV comorbidities, such as lipid-lowering agents, proton pump inhibitors and anticancer drugs. However, the studies do not seem to be consistent with regard to sample size and follow-up, the drugs involved, or the results obtained. It should be noted that most of the available studies were conducted in healthy volunteers without being replicated in patients. This hampered the assessment of the clinical burden of DDIs and, consequently, the optimal pharmacological management of people living with HIV.
Riboflavin- and Hypericin-Mediated Antimicrobial Photodynamic Therapy as Alternative Treatments for Oral Candidiasis: A Systematic Review
Authors: Łopaciński Maciej , Fiegler-Rudol Jakub , Niemczyk Wojciech , Skaba Dariusz , Wiench Rafał
Published: December 2024

Background: Oral candidiasis, predominantly caused by Candida albicans, presents significant challenges in treatment due to increasing antifungal resistance and biofilm formation. Antimicrobial photodynamic therapy (aPDT) using natural photosensitizers like riboflavin and hypericin offers a potential alternative to conventional antifungal therapies. Material and Methods: A systematic review was conducted to evaluate the efficacy of riboflavin- and hypericin-mediated aPDT in reducing Candida infections. The PRISMA framework guided the selection and analysis of 16 eligible studies published between 2014 and 2024. Data on light parameters, photosensitizer concentrations, and outcomes were extracted to assess antifungal effects. Results: Both riboflavin- and hypericin-mediated aPDT demonstrated significant antifungal activity, achieving substantial reductions in Candida biofilm and planktonic cell viability. Riboflavin activated by blue light and hypericin activated by yellow or orange light effectively targeted fluconazole-resistant Candida strains with minimal cytotoxicity to host tissues. However, complete biofilm eradication remained challenging, and variations in protocols highlighted the need for standardization. Conclusions: Riboflavin- and hypericin-mediated aPDT present promising, biocompatible alternatives for managing antifungal resistance in Candida infections. Further clinical trials and standardized protocols are essential to optimize outcomes and confirm efficacy in broader clinical settings.
Gestational Diabetes Mellitus Does Not Change the Pharmacokinetics and Transplacental Distribution of Fluoxetine and Norfluoxetine Enantiomers
Authors: Carvalho Daniela Miarelli , Nardotto Glauco Henrique Balthazar , Filgueira Gabriela Campos de Oliveira , Duarte Geraldo , Cavalli Ricardo Carvalho , Lanchote Vera Lucia , Moisés Elaine Christine Dantas
Published: December 2024

Background/Objectives: Fluoxetine (FLX) is the inhibitor of serotonin reuptake most prescribed in pregnant women with depression. This study evaluates the influence of gestational diabetes mellitus (GDM) on the enantioselective pharmacokinetics and transplacental distribution of FLX and its metabolite norfluoxetine (norFLX). Methods: Ten pregnant women diagnosed with GDM (GDM group) were investigated in the third trimester of gestation after they achieved good glycemic control. They received a single oral dose of 20 mg FLX, and blood samples were collected from 0 to 672 h. On the day of delivery, after another single oral dose of 20 mg FLX, blood samples of maternal vein, umbilical vessels and intervillous space were collected at birth. The pharmacokinetics parameters obtained for pregnant women diagnosed with GDM were compared with a group of healthy pregnant women (n = 9) previously investigated using Kruskal–Wallis’s rank-sum test with the Dunn–Bonferroni post hoc test. Results: The area under the plasma over time curve (AUC0–∞) were 197.93 and 109.62 ng∙h/mL for FLX and 600.39 and 960.83 ng∙h/mL for norFLX, respectively, for their R-(+)- and S-(-)- enantiomers. The umbilical vein/maternal vein ratio for FLX and norFLX enantiomers was nearly 0.3, inferring low placental transfer. The umbilical artery/umbilical vein ratios were nearly 0.7 for both FLX and norFLX enantiomers, indicating absence or small fetal metabolism. Conclusions: The GDM did not alter the pharmacokinetics of FLX and norFLX enantiomers in patients with good glycemic control evaluated in the third trimester of gestation.
RETRACTED: Elsherif et al. Investigation of the Potential of Nebivolol Hydrochloride-Loaded Chitosomal Systems for Tissue Regeneration: In Vitro Characterization and In Vivo Assessment. Pharmaceutics 2021, 13, 700
Authors: Elsherif Noha Ibrahim , Al-Mahallawi Abdulaziz Mohsen , Abdelkhalek Abdelfattah Ahmed , Shamma Rehab Nabil
Published: December 2024

The journal retracts the article “Investigation of the Potential of Nebivolol Hydrochloride-Loaded Chitosomal Systems for Tissue Regeneration: In Vitro Characterization and In Vivo Assessment” [...]
Improving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients
Authors: Marques Lara , Vale Nuno
Published: December 2024

Background: Salbutamol, a short-acting β2-agonist used in asthma treatment, is available in multiple formulations, including inhalers, nebulizers, oral tablets, and intravenous, intramuscular, and subcutaneous routes. Each formulation exhibits distinct pharmacokinetic (PK) and pharmacodynamic (PD) profiles, influencing therapeutic outcomes and adverse effects. Although asthma management predominantly relies on inhaled salbutamol, understanding how these formulations interact with patient-specific characteristics could improve personalized medicine approaches, potentially uncovering the therapeutic benefits of alternative formulations for an individual patient. Herein, this study aims to analyze how covariates—such as age, weight, gender, body surface area (BSA), cytochrome P450 (CYP) expression, race, and health status—affect the therapeutic regime of orally administered salbutamol using population PK (popPK) modeling. The final model is intended as a tool to support the selection of optimal formulation and dosage regimen based on individual patient profiles. Methods: A dataset of 40 virtual patients derived from a physiologically based PK (PBPK) model of oral salbutamol was included in the popPK model. Results: A two-compartment model with first-order elimination and absorption, with a transit compartment, best described the plasma concentration–time profile following a 4 mg dose. Relationships were identified between gender and mean transit time (Mtt) and clearance (Cl), as well as the effects of weight and BSA on the volume of distribution of the central compartment (V1) and Cl, and a significant impact of health status on Cl. Conclusions: Despite current contraindications for oral salbutamol, our findings suggest that certain individuals, particularly children, may benefit from oral treatment over inhalation. We also identified individual characteristics associated with increased salbutamol toxicity risk, indicating the need for dose adjustment or alternative administration. This study further highlights the potential of popPK modeling in personalized therapy through a fully in silico approach.
Functional Nanocarbon Hybrids in Metal Oxide Nanocomposites for Photocatalysis
Authors: Debes Paul P. , Pagel Melanie , Muntean Simeon , Hessling Janis , Smarsly Bernd M. , Schönhoff Monika , Gatti Teresa
Published: December 2024

The textile industry is a major contributor to environmental pollution, primarily through the discharge of wastewater loaded with dyes and contaminants that disrupt natural ecosystems. This study aims to develop a hybrid material by functionalizing carbon nanodots (CNDs) with the donor-π-acceptor organic dye L1 via amide coupling. By chemically modifying the surface of CNDs, we can enhance their multifunctionality and tailor their molecular composition. This innovative approach seeks to replace expensive dyes with cost-effective CNDs synthesized from citric acid and ethylenediamine using a domestic microwave oven, potentially improving the stability of the resulting hybrid. Additionally, TiO2 anatase particles were synthesized as a metal oxide platform and sensitized with both pristine materials and the CND-L1 hybrid. A range of physicochemical methods was employed to analyze the elemental, structural, and optical properties of these materials. In photocatalytic degradation tests of methyl orange, the sensitized catalysts demonstrated significantly improved efficiency compared to TiO2 alone. While CNDs exhibited good stability and enhanced L1’s stability, scavenger experiments revealed that holes and hydroxyl radicals play crucial roles in the degradation mechanism. This research underscores the promise of CND hybrids in advancing pollutant degradation technologies while reducing reliance on costly photocatalysts.
Tunable Single-Longitudinal-Mode Thulium–Holmium Co-Doped Fiber Laser with an Ultra-Narrow Linewidth by Utilizing a Triple-Ring Passive Sub-Ring Resonator
Authors: Wang Pengfei , Yan Fengping , Qin Qi , Yang Dandan , Feng Ting , Liu Peng , Li Ting , Yu Chenhao , Wang Xiangdong , Guo Hao , Cai Yuezhi , Ji Wenjie , Jiang Youchao
Published: December 2024

A low-cost, wavelength-tunable single-longitudinal-mode (SLM) thulium–holmium co-doped fiber laser (THDFL) in a 2 μm band with a simple structure is described in the present paper. To obtain a stable SLM and narrow laser linewidth, a five-coupler-based three-ring (FCTR) filter is utilized in the ring cavity of the fiber laser. Tunable SLM wavelength output from THDFLs with kHz linewidths can be achieved by designing the FCTR filter with an effective free-spectral range and a 3 dB bandwidth at the main resonant peak. The measurement results show that the laser is in the SLM lasing state, with a highly stabilized optical spectrum, a linewidth of approximately 9.45 kHz, an optical signal-to-noise ratio as high as 73.6 dB, and a relative intensity noise of less than −142.66 dB/Hz. Furthermore, the wavelength can be tuned in the range of 2.6 nm. The proposed fiber laser has a wide range of applications, including coherence optical communication, optical fiber sensing, and dense wavelength-division-multiplexing.
Scattering Improves Temporal Resolution of Vision: A Pilot Study on Brain Activity
Authors: Ávila Francisco J.
Published: December 2024

Temporal vision is a vital aspect of human perception, encompassing the ability to detect changes in light and motion over time. Optical scattering, or straylight, influences temporal visual acuity and the critical flicker fusion (CFF) threshold, with potential implications for cognitive visual processing. This study investigates how scattering affects CFF using an Arduino-based psychophysical device and electroencephalogram (EEG) recordings to analyze brain activity during CFF tasks under scattering-induced effects. A cohort of 30 participants was tested under conditions of induced scattering to determine its effect on temporal vision. Findings indicate a significant enhancement in temporal resolution under scattering conditions, suggesting that scattering may modulate the temporal aspects of visual perception, potentially by altering neural activity at the temporal and frontal brain lobes. A compensation mechanism is proposed to explain neural adaptations to scattering based on reduced electrical activity in the visual cortex and increased wave oscillations in the temporal lobe. Finally, the combination of the Arduino-based flicker visual stimulator and EEG revealed the excitatory/inhibitory stimulation capabilities of the high-frequency beta oscillation based on the alternation of an achromatic and a chromatic stimulus displayed in the CFF.
An Efficient Frequency Encoding Scheme for Optical Convolution Accelerator
Authors: Xia Gongyu , Liu Jiacheng , Hong Qilin , Zhu Pingyu , Xu Ping , Zhu Zhihong
Published: December 2024

In today’s era where the demand for computational resources by large models is increasingly high, optical computing offers an alternative physical platform for computation. With its high parallelism and the maturation of integrated photonic technologies, optical computing is expected to further support the computational resources required by large models. For one-dimensional optical convolution accelerators, existing methods can fully utilize the working bandwidth of electro-optic modulators and the frequency resources of light sources. However, most convolution computations currently require the execution of two-dimensional matrix convolutions, and existing encoding schemes suffer a drop in terms of effective computations per second when performing two-dimensional matrix convolutions. In response to this, we propose a new encoding scheme that can fully utilize the computational resources of optical convolution accelerators. For convolution operations with a kernel size of M×M, compared to existing encoding schemes, it can achieve an M-fold increase in effective computation rate. This implies that under the constraints of essentially the same hardware physical performance, adopting our newly proposed encoding scheme can achieve a significant improvement in computational performance. We construct an optical convolution acceleration system to demonstrate the principles of the new encoding.
Atomic-Scale Study of NASICON Type Electrode Material: Defects, Dopants and Sodium-Ion Migration in Na3V2(PO4)3
Authors: Seshan Vijayabaskar , Iyngaran Poobalasuntharam , Abiman Poobalasingam , Kuganathan Navaratnarajah
Published: December 2024

Na3V2(PO4)3 (NVP), a NASICON-type material, has gained attention as a promising battery cathode owing to its high sodium mobility and excellent structural stability. Using computational simulation techniques based on classical potentials and density functional theory (DFT), we examine the defect characteristics, diffusion mechanisms, and dopant behavior of the NVP. The study found that the Na Frenkel defect is the most favorable intrinsic defect, supporting the desodiation process necessary for capacity and enabling vacancy-assisted Na-ion migration. The Na migration is anticipated through a long-range zig-zag pathway with an overall activation energy of 0.70 eV. K and Sc preferentially occupy Na and V sites without creating charge-compensating defects. Substituting Mg at the V site can simultaneously increase Na content by forming interstitials and reducing the band gap. Additionally, doping Ti at the V site promotes the formation of Na vacancies necessary for vacancy-assisted migration, leading to a notable improvement in electronic conductivity.
Application of Supercritical CO2 Extraction and Identification of Polyphenolic Compounds in Three Species of Wild Rose from Kamchatka: Rosa acicularis, Rosa amblyotis, and Rosa rugosa
Authors: Razgonova Mayya P. , Nawaz Muhammad A. , Rusakova Elena A. , Golokhvast Kirill S.
Published: December 2024

A comparative metabolomic study of three varieties of wild Rosa (Rosa acicularis, Rosa amblyotis, and Rosa rugosa) from a Kamchatka expedition (2024) was conducted via extraction with supercritical carbon dioxide modified with ethanol (EtOH), and detection of bioactive compounds was realized via tandem mass spectrometry. Several experimental conditions were investigated in the pressure range 50–350 bar, with the used volume of co-solvent ethanol in the amount of 2% in the liquid phase at a temperature in the range of 31–70 °C. The most effective extraction conditions are the following: pressure 200 Bar and temperature 55 °C for Rosa acicularis; pressure 250 Bar and temperature 60 °C for Rosa amblyotis; pressure 200 Bar and temperature 60 °C for Rosa rugosa. Three varieties of wild Rosa contain various phenolic compounds and compounds of other chemical groups with valuable biological activity. Tandem mass spectrometry (HPLC-ESI–ion trap) was applied to detect the target analytes. A total of 283 bioactive compounds (two hundred seventeen compounds from the polyphenol group and sixty-six compounds from other chemical groups) were tentatively identified in extracts from berries of wild Rosa. For the first time, forty-eight chemical constituents from the polyphenol group (15 flavones, 14 flavonols, 4 flavan-3-ols, 3 flavanones, 1 phenylpropanoid, 2 gallotannins, 1 ellagitannin, 4 phenolic acids, 1 dihydrochalcone, and 3 coumarins) were identified in supercritical extracts of R. acicularis, R. amblyotis, and R. rugosa.
Influence of 3D Printing Conditions on Physical–Mechanical Properties of Polymer Materials
Authors: Beníček Lubomír , Vašina Martin , Hrbáček Pavel
Published: December 2024

The popularity of 3D printing technology is rapidly increasing worldwide. It can be applied to metals, ceramics, composites, hybrids, and polymers. Three-dimensional printing has the potential to replace conventional manufacturing technologies because it is cost effective and environmentally friendly. This paper focuses on the influence of 3D printing conditions on the physical and mechanical properties of polylactic acid (PLA), poly(methyl methacrylate) (PMMA), and poly(ethylene terephthalate glycol-modified) (PETG) materials produced using Fused Deposition Modeling (FDM) technology. The impact of nozzle diameter, layer height, and printing temperature on the mechanical (i.e., bending stiffness and vibration damping) and physical (i.e., sound absorption and light transmission) properties of the studied polymer materials was investigated. It can be concluded that 3D printing conditions significantly influenced the structure and surface shape of the 3D-printed polymer samples and, consequently, their physical and mechanical properties. Therefore, it is essential to consider the type of filament used and the 3D printing conditions for specific 3D-printed material applications.
Analysis of Electrical Conductivity in Commercial Adhesives Incorporating Graphene Nanoplatelets for Industrial Applications
Authors: Fernández Pablo Rodríguez , García Cristina Alía
Published: December 2024

Polymers are often insulators, but this not a universal intrinsic characteristic of all polymers. For this work, the adhesives used, epoxy and polyurethane, do demonstrate this insulating characteristic. However, there has been significant interest in the development of conductive polymers, specifically adhesives, because of the potential properties and ease of processing of these polymers. The electrical-conductivity values for two composites reinforced with graphene nanoplatelets (GNPs) were measured. Both matrices are intended for industrial usage. One composite used an epoxy matrix, while the other employed a polyurethane resin as the matrix. To achieve dispersion and exfoliation of the filler, the catalyst for each resin, mixed with the GNP in proportion, was subjected to an ultrasonic bath for 30 min. The molds were filled by gravity, with the polyurethane specimens leveled to improve surface finish. The two-point uniaxial method was used to measure the conductivity of the specimens at room temperature, both before and after annealing at 120 °C for 120 min. Conductivity values were obtained for all samples, showing an increase after annealing; however, this increase was less pronounced compared to similar studies. The time and power in the ultrasonic bath, as well as the annealing conditions, must be optimized and the electrical conductivity should be studied periodically.
Analysis of Residual Stress at the Interface of Epoxy-Resin/Silicon-Wafer Composites During Thermal Aging
Authors: Wu Jianyu , Chen Fangzhou , Liu Jiahao , Chen Rui , Liu Peijiang , Zhao Hao , Zhao Zhenbo
Published: December 2024

During the thermal aging process of epoxy resin, microcracks, interfacial delamination, and warpage are the key factors leading to semiconductor device damage. Here, epoxy-resin specimens (EP-Ss) and epoxy-resin/silicon-wafer composites (EP-SWs) were prepared to analyze the distribution of residual stress (RS) in epoxy resin and its thermal aging process changes. The uniaxial tensile approach and Raman spectroscopy (RAS) showed that the peak shift of aliphatic C-O in EP-Ss was negatively correlated with the external stress, and that the stress correlation coefficient was −2.76 × 10−2 cm−1/MPa. Then, RAS was used to evaluate the RS distribution of EP-SWs, obtaining a high-resolution stress-distribution image of 50 × 50 pixels and revealing a strong stress concentration at the interface between the epoxy resin and the silicon wafer. Additionally, Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), Field-emission scanning electron microscopy (FE-SEM), and RAS were used to analyze the chemical composition, molecular structure, interfacial microstructure, and RS of the epoxy resin during the thermal aging process. With the increase in the thermal aging time, the epoxy resin underwent secondary curing, the RS at the interface changed from tensile stress to compressive stress, and cracks were formed. The results illuminate the effect of the thermal aging process on the interface-failure mechanism of composite materials, aiding in the reliability evaluation and safety design of semiconductor devices.
Increasing the Permeability of Polyphenylene Sulfone Hollow Fiber Ultrafiltration Membranes by Switching the Polymer End Groups
Authors: Raeva Alisa , Matveev Dmitry , Anokhina Tatyana , Zhansitov Azamat A. , Khashirova Svetlana , Volkov Vladimir , Borisov Ilya
Published: December 2024

The influence of the molecular weight and chemical structure of polyphenylene sulfone (PPSU) end groups on the formation of the porous structure of ultrafiltration (UF) hollow fiber membranes was investigated. Polymers with a molecular weight ranging from 67 to 81 kg/mol and with a hydroxyl-to-chlorine end group ratio ranging from 0.43 to 17.0 were synthesized. The excess of end groups was achieved during polymer synthesis by adding one of the following monomers: hydroxyl (excess DHBP) or chlorine (excess DCDPS). For the first time, it was found that the stability of PPSU solutions is determined not by the molecular weight of the polymer, but by the chemical structure of its end groups. The stability of polymer solutions increases with the increasing proportion of chlorine groups. The SEM method showed that with the increasing molar fraction of chlorine end groups in the polymer, a more open porous structure forms on the outer surface of the hollow fiber membranes derived from it. The maximum UF permeance of the hollow fiber membranes for water was achieved with the PPSU sample containing the highest chlorine end group content, amounting to 136 L/(m2·h·bar), with a high rejection of the model substance Blue Dextran (at 94.7%). This represents the best result currently reported among unmodified PPSU hollow fiber membranes.
Deterioration Behavior of Concrete Beam Reinforced with Carbon Fiber-Reinforced Plastic Rebar Exposed to Carbonation and Chloride Conditions
Authors: Lee Seung-Yun , Kim Sun-Hee , Choi Wonchang
Published: December 2024

The absence of carbon fiber-reinforced rebar performance standards in Korea has limited its reliability. This study investigates the durability performance of carbon fiber-reinforced polymer rebar as an alternative to traditional steel reinforcement in concrete structures. Concrete beams reinforced with carbon fiber-reinforced polymer rebar were exposed to chloride environments for durations of 35 and 70 days and then subjected to bending tests to evaluate their durability. The results demonstrate that the strong bond between the carbon fiber-reinforced polymer and concrete effectively prevented brittle fracture, even under exposure to harsh chloride. A scanning electron microscope analysis of the specimens exposed to chloride showed no deterioration of the carbon fiber-reinforced polymer rebar, highlighting its exceptional resistance to corrosion. Furthermore, durability tests were conducted in a carbonation chamber for 8 and 12 weeks, with no signs of degradation in the carbon fiber-reinforced polymer rebar. These findings suggest that carbon fiber-reinforced polymer rebar offers excellent resistance to both chloride-induced corrosion and carbonation, making it a promising solution to enhance the longevity and durability of reinforced concrete structures exposed to aggressive environmental conditions.
Effect of Orange Juice on the Properties of Heat-Polymerized and 3D-Printed Denture Materials
Authors: Tosun Büşra , Öztürk Zeynep , Uysal Nur
Published: December 2024

This study evaluated the color stability, surface roughness, and hardness of 3D-printed and heat-polymerized denture materials. A total of 90 samples were prepared, with equal numbers of 3D-printed and heat-polymerized disks. The initial hardness, surface roughness, and color values of the samples were measured. After 14 days of immersion in distilled water, natural orange juice, or commercial orange juice, the measurements were repeated. Based on the findings, 3D-printed samples exhibited a greater reduction in Vickers hardness (56.24 ± 15.81%) compared to heat-polymerized samples (18.93 ± 11.41%). Materials immersed in commercial orange juice exhibited a greater reduction in hardness compared to those in other solutions (43.13 ± 23.66). Surface roughness increased by 46.66 ± 26.8% in heat-polymerized samples and by 26.16 ± 20.78% in 3D-printed samples, with the highest increase observed in commercial orange juice (50.73 ± 28.8%) (p < 0.001). The color change (ΔE) was significantly higher in heat-polymerized samples (ΔE = 5.05 ± 0.28) than in 3D-printed samples (ΔE = 3.9 ± 0.26) (p < 0.001). This study demonstrates that the material type and immersion solutions play a critical role in determining the mechanical and optical properties of denture materials, with commercial orange juice having the most pronounced effect on surface roughness and hardness.
Innovative Blown Multi-Micro-Nano-Layer Coextrusion: Insights into Rheology and Process Stability
Authors: Vozikis Lazaros , Mani Skander , Maazouz Abderrahim , Lamnawar Khalid
Published: December 2024

The present study introduces an innovative blown coextrusion die technology designed to address a critical gap in the production of multilayer films. Unlike conventional systems, this novel die allows for the creation of films with a high number of layers, ensuring layer integrity even in the micro-nano scale. A key advancement of this die is its ability to increase the number of layers without extending the residence time since it does not require an additional multiplier element. The risk of thermal degradation can, thus be, minimized. The die can easily be combined with existing cast coextrusion technologies, making it very versatile. Stability maps were developed to define processability and, in association with rheological analysis, optimal processing windows were determined. This study highlights the potential of enhancing material efficiency by increasing the number of layers while reducing the need for high percentages of EVOH. The produced multilayer films exhibited strong layer adhesion without the use of tie layers, thus improving recyclability and supporting sustainability goals.
Optimization of the Heterogeneous Synthesis Conditions for Cellulose Tosylation and Synthesis of a Propargylamine Cellulosic Derivative
Authors: Ferreira Marcos V. , Ricci Poliana , Sobreira Henrique A. , Faria Anizio M. , Panatieri Rodrigo B. , Sumerlin Brent S. , Assunção Rosana M. N.
Published: December 2024

Cellulose tosylate (MCC-Tos) is a key derivative for surface modification and a crucial precursor for cellulose compatibilization in click reactions, enabling its functionalization for advanced applications. Replacing tosyl groups with alkyne groups broadens cellulose’s potential in biocompatible reactions, such as thiol-yne click chemistry and protein/enzyme immobilization. To achieve this, we optimized the heterogeneous synthesis of MCC-Tos using a Doehlert matrix statistical design, evaluating the influence and interaction of the reaction conditions. The optimized conditions—144 h reaction time, 10:1 molar ratio, and 30 °C—yielded a degree of substitution for tosyl groups (DStos) of 1.80, determined via elemental analysis and FTIR-ATR spectroscopy. The reaction kinetics followed a first-order model. A subsequent reaction with propargylamine produced aminopropargyl cellulose (MCC-PNH), reducing DStos by 65%, which was confirmed via FTIR, and improving thermal stability by a margin of 30 °C (TGA/DTG). 13C CP/MAS NMR confirmed the alkyne group attachment, further validated via coupling an azide-functionalized coumarin through copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC). Fluorescence microscopy and UV spectroscopy were used to estimate a substitution degree of 0.21. This study establishes a feasible route for synthesizing alkyne-functionalized cellulose, paving the way for eco-friendly materials, including protein/enzyme bioconjugates, composites, and advanced materials via thiol-yne and CuAAC reactions.
Redox-Active Water-Soluble Low-Weight and Polymer-Based Anolytes Containing Tetrazine Groups: Synthesis and Electrochemical Characterization
Authors: Kozhunova Elena Yu. , Sentyurin Vyacheslav V. , Inozemtseva Alina I. , Nikolenko Anatoly D. , Khokhlov Alexei R. , Magdesieva Tatiana V.
Published: December 2024

Polymer-based aqueous redox flow batteries (RFBs) are attracting increasing attention as a promising next-generation energy storage technology due to their potential for low cost and environmental friendliness. The search for new redox-active organic compounds for incorporation into polymer materials is ongoing, with anolyte-type compounds in high demand. In response to this need, we have synthesized and tested a range of new water-soluble redox-active s-tetrazine derivatives, including both low molecular weight compounds and polymers with different architectures. S-tetrazines are some of the smallest organic molecules that can undergo a reversible two-electron reduction in protic media, making them a promising candidate for anolyte applications. We have successfully modified linear polyacrylic acid and poly(N-isopropylacrylamide-co-acrylic acid) microgels with pendent 1,2,4,5-tetrazine groups. Electrochemical testing has shown that the new tetrazine-containing monomers and, importantly, the water-soluble redox polymers, both linear and microgel, demonstrate the chemical reversibility of the reduction process in an aqueous solution containing acetate buffer. This expands the range of water-soluble anodic materials suitable for water-based organic RFBs. The reduction potential value can be adjusted by changing the substituents in the tetrazine core. It is also worth noting that the choice of electrode material plays an important role in the kinetics of the tetrazine reaction: the use of carbon electrodes is particularly beneficial.
Stress Zoning Characteristics and Migration of Leaked Methane from Gas Wells Penetrating Protective Coal Pillars in Longwall Mining Areas
Authors: Shen Jinhang , Liang Shun , Hao Yisong , Ma Zhi , He Weisheng , Liang Xu , Xu Shaoyou , Luo Changheng
Published: December 2024

There are a large number of abandoned or casing-damaged oil/gas wells in the western mining areas of China. Under the influence of mining-induced stress, the methane leaked from the oil and gas wells will be transported through fracture within the coal pillar to the longwall working face, which will seriously threaten the safe mining of coal resources. There is no mandatory standard for the practice of coal pillars in coal and gas wells in coal/gas overlapping areas, and the problems of oversized coal pillars and waste of coal resources have occurred during the implementation. In this study, through finite element numerical simulation, three different sizes of protective coal pillars are modeled in the background of Shuangma Coal Mine. The impacts of different heights and widths of protective coal pillars on the evolution of stresses and the diffusion process of leaked methane are explored, and the spatial and temporal migration law of leaked methane under multi-field coupling is revealed. The results show that under mining-induced stress, the size of the protective coal pillar has a significant effect on the stress distribution and methane transport law. Compared with the 130 m coal pillar, the peak stress of the 150 m coal pillar decreased by 6.7%, and the peak stress of the 180 m coal pillar decreased by 9%. At 150 m and 180 m widths, the permeability difference between the two sides is only 1 mD, and the diffusion ranges are similar. From the stress distribution and gas diffusion law, it is shown that the effect achieved by 150 m and 180 m coal pillars is similar. This work is of great significance for the reasonable remaining protective coal pillars for oil/gas wells penetrating longwall mining areas, as well as the prevention and control of disasters caused by leaked methane from wells.
Fault Diagnosis Techniques for Electrical Distribution Network Based on Artificial Intelligence and Signal Processing: A Review
Authors: Cao Yunyu , Tang Jinrui , Shi Shaohui , Cai Defu , Zhang Li , Xiong Ping
Published: December 2024

This paper provides a comprehensive and systematic review of fault diagnosis methods based on artificial intelligence (AI) in smart distribution networks described in the literature. For the first time, it systematically combs through the main fault diagnosis objectives and corresponding fault diagnosis methods for a smart distribution network from the perspective of combined signal processing and artificial intelligence algorithms. The paper provides an in-depth analysis of the advantages and disadvantages of various signal processing techniques and intelligent algorithms in different fault diagnosis tasks, focusing on the impact of different data dimensions on the effect of fault diagnosis. This paper points out that data security issues and the question of how to combine expert domain knowledge with artificial intelligence technology are essential directions for the future development of fault diagnosis in smart distribution network.
Analyzing the Impact of Wind on Trajectory Tracking for Unmanned Vehicles Based on Road Adhesion Coefficient Estimation
Authors: Luo Zhichao , Zheng Yanping
Published: December 2024

This paper presents a novel approach to address the challenge of trajectory tracking control in unmanned vehicles (UVs) operating on roads with varying ad hesion coefficients and subject to wind disturbances. The proposed method integrates real-time estimation of road adhesion coefficients with a wind disturbance model, embedding both into the trajectory tracking control system. Specifically, the Unscented Kalman Filter (UKF) is employed to dynamically estimate the road adhesion coefficients. These estimates are then combined with the wind disturbance model and incorporated into a Model Predictive Control (MPC) framework, enhancing the robustness and accuracy of trajectory tracking under varying conditions. The integrated simulation results from CarSim/Simulink demonstrate high accuracy in road adhesion coefficient estimation for trajectory tracking control, with tracking errors consistently remaining below 0.1 across different road adhesion conditions. For example, the road adhesion coefficient estimation error for the docking surface is 0.5%, and for the split road surface, it is 0.75%, indicating the approach’s applicability across a wide range of road conditions. Notably, when the wind speed reaches level-five intensity and a shelter-type vehicle is used as a test case, the proposed controller significantly outperforms the controller that does not consider wind effects. Under both high and low adhesion conditions, the controller reduces the yaw angle by approximately 15% and 30%, respectively, and the yaw rate by approximately 25% and 20%. These results provide strong evidence for the effectiveness of the proposed trajectory tracking controller in enhancing the stability and control performance of unmanned vehicles.
Research on the Harmless Treatment of Barium Slag Using Flue Gas Desulfurization Gypsum
Authors: Wan Yang , Chen Zhou , Cao Xiaohui , Song Xin , Zhan Yu , Ma Chunting , Zhang Siqi , Ni Wen
Published: December 2024

This study proposes an innovative method for the harmless treatment of barium slag using the industrial by-product Flue Gas Desulfurization Gypsum. Barium slag is a by-product of the barium carbonate production process, and due to its high content of barium ions and corrosive properties, it poses a significant threat to the environment and human health. It is classified as barium-containing hazardous waste (code HW47) in China. In this study, barium slag was optimally combined with FGD gypsum, utilizing a synergistic precipitation mechanism to solidify the easily leachable barium ions and form stable sulfate minerals. Mechanical and heavy metal leaching tests showed that the harmlessly treated barium slag had a certain compressive strength, and the concentration of barium ions in the leachate was below the national hazardous waste identification standards (100 mg/L) and the drinking water quality standards (0.7 mg/L). Microstructural analysis using X-ray diffraction, Fourier Transform Infrared Spectroscopy, scanning electron microscopy, and energy-dispersive X-ray spectroscopy indicated that FGD gypsum promotes the solidification of barium slag, and through the synergistic precipitation mechanism, low-solubility barium sulfate minerals are formed. This treatment method also has a low cost and good potential for resource utilization, providing effective technical support for the green treatment of industrial waste.
HRAMS Proteomics Insights on the Anti-Filarial Effect of Ocimum sanctum: Implications in Phytochemical-Based Drug-Targeting and Designing
Authors: Mishra Ayushi , Kumar Vipin , Kumar Sunil , Singh HariOm , Singh Anchal
Published: December 2024

Lymphatic filariasis (LF) continues to impact 657 million individuals worldwide, resulting in lifelong and chronic impairment. The prevalent anti-filarial medications—DEC, albendazole, and ivermectin—exhibit limited adulticidal efficacy. Despite ongoing LF eradication programs, novel therapeutic strategies are essential for effective control. This study examines the mechanism of action of Ocimum sanctum on the filarial parasites Setaria cervi via a synergistic biochemical and proteomics methodology. The ethanolic extract of Ocimum sanctum (EOS) demonstrated potential anti-filarial action in the MTT reduction experiment, with an LC50 value of 197.24 µg/mL. After EOS treatment, an elevation in lipid peroxidation (51.92%), protein carbonylation (48.99%), and NADPH oxidase (88.88%) activity, along with a reduction in glutathione (GSH) (−39.23%), glutathione reductase (GR) (−60.17%), and glutathione S transferase (GST) (−50.48%) activity, was observed. The 2D gel electrophoresis identified 20 decreased and 11 increased protein spots in the EOS-treated parasites relative to the control group. Additionally, in drug docking analysis, the EOS bioactive substances ursolic acid, rutin, and rosmarinic acid show a significant binding affinity with the principal differentially expressed proteins. This paper demonstrates, for the first time, that the anti-filarial efficacy of EOS is primarily facilitated by its impact on energy metabolism, antioxidant mechanisms, and stress response systems of the parasites.
The Prevalence and Risk Factors of Workplace Violence at a Psychiatric Hospital in The Gambia
Authors: Jallow Amadou D. , Punpeng Twisuk , Boonshuyar Chaweewon
Published: December 2024

Purpose—This study aimed to provide a comprehensive report of workplace violence (WPV) at a psychiatric hospital in Gambia. Design/methodology/approach—A cross-sectional study involving self-administered questionnaires and an in-depth interview was conducted with 54 staff at the hospital and six senior managers of mental health treatment in Gambia. A descriptive statistical approach was applied to determine the prevalence, and a logistic regression approach was used to identify factors associated with violence at the hospital. The data from the in-depth interviews on WPV policies in Gambia were analysed thematically. Results—In the 12 months before the research, 55.6% of the respondents had been exposed to violence; of those, 46.3%, 27.8%, and 5.6% had experienced verbal abuse, physical assault, and sexual harassment, respectively. Inadequate staff, insufficient security measures, and insufficient medications were perceived by respondents as the causes of the violence. However, the level of professionalism, the kind of services provided by staff, and shift of work were strongly connected with violence. As a result of WPV, victims had injuries, posttraumatic stress disorder signs/symptoms, and work dissatisfaction. The interviewees also expressed concern about the lack of WPV polices and the necessity of creating such polices as soon as possible. Value—According to the research, there is an elevated risk of violence among the hospital staff. As a result, the hospital’s structure needs to change, staff members should receive training on how to address aggressive patients, and a constructive WPV policy should be created.
Uranium and Religion: Toward a Decolonial Temporality of Extraction
Authors: Nichols Amanda M.
Published: December 2024

Uranium mining for the production of nuclear technologies has left visible scars across the United States and perpetuated legacies of extraction that extend beyond material consumption to the exploitation of people and the environment. Influenced by important ongoing conversations in the environmental and energy humanities, posthumanism, and decolonial studies, I analyze how uranium extraction has been conceived of as an “event” within a colonial temporal framework. A critical examination of how religious worldviews have informed the ways that time is conceptualized and understood shifts thinking about extraction away from colonial temporalities and helps reimagine extraction through a decolonial perspective as temporally distributed, enmeshed, and complex. This reframing is imperative to foster an understanding that the radioactive byproducts of uranium created through the nuclear production process are globally dispersed, will persist across generations, and will have transgenerational implications for human and non-human organisms and the health and viability of ecologic systems.