bluuebunny/crossref_metadata_2025 huggingface dataset:
Natural Fiber-Reinforced Composite Incorporated with Anhydride-Cured Epoxidized Linseed-Oil Resin and Atmospheric Pressure Plasma-Treated Flax Fibers
Authors: Savicheva Sofya , Rapp Bastian E. , Teuscher Nico
Published: August 2024

Fiber-reinforced composites (FRCs) represent a promising class of engineering materials due to their mechanical performance. However, the vast majority of FRCs are currently manufactured using carbon and glass fibers, which raises concerns because of the difficulties in recycling and the reliance on finite fossil resources. On the other hand, the use of natural fibers is still hampered due to the problems such as, e.g., differences in polarity between the reinforcement and the polymer matrix components, leading to a significant decrease in composite durability. In this work, we present a natural fiber-reinforced composite (NFRC), incorporating plasma pre-treated flax fibers as the reinforcing element, thermoplastic polylactic acid (PLA) as a matrix, and a key point of the current study—a thermoset coating based on epoxidized linseed oil for adhesion improvement. Using atmospheric plasma-jet treatment allows for increasing the fiber’s surface energy from 20 to 40 mN/m. Furthermore, a thermoset coating layer based on epoxidized linseed oil, in conjunction with dodecyl succinic anhydride (DDSA) as a curing agent and 2,4,6-tris(dimethyl amino methyl) phenol (DMP-30) as a catalyst, has been developed. This coated layer exhibits a decomposition temperature of 350 °C, and there is a substantial increase in the dispersive surface-energy part of the coated flax fibers from 8 to 30 mN/m. The obtained natural fiber-reinforced composite (NFRC) was prepared by belt-pressing with a PLA film, and its mechanical properties were evaluated by tensile testing. The results showed an elastic modulus up to 18.3 GPa, which is relevant in terms of mechanical properties and opens up a new pathway to use natural-based fiber-reinforced bio-based materials as a convenient approach to greener FRCs.
Calcium Silicate-Based Cements in Restorative Dentistry: Vital Pulp Therapy Clinical, Radiographic, and Histological Outcomes on Deciduous and Permanent Dentition—A Systematic Review and Meta-Analysis
Authors: Xavier Maria Teresa , Costa Ana Luísa , Ramos João Carlos , Caramês João , Marques Duarte , Martins Jorge N. R.
Published: August 2024

Vital pulp therapy aims to preserve the vitality of dental pulp exposed due to caries, trauma, or restorative procedures. The aim of the present review was to evaluate the clinical, radiographic, and histological outcomes of different calcium silicate-based cements used in vital pulp therapy for both primary and permanent teeth. The review included 40 randomized controlled trials from a search across PubMed, LILACS, and the Cochrane Collaboration, as well as manual searches and author inquiries according to specific inclusion and exclusion criteria. A critical assessment of studies was conducted, and after data extraction the results were submitted to a quantitative statistical analysis using meta-analysis. The studies, involving 1701 patients and 3168 teeth, compared a total of 18 different calcium silicate-based cements in both dentitions. The qualitative synthesis showed no significant differences in short-term outcomes (up to 6 months) between different calcium silicate-based cements in primary teeth. ProRoot MTA and Biodentine showed similar clinical and radiographic success rates at 6 and 12 months. In permanent teeth, although the global results appeared to be well balanced, ProRoot MTA generally seemed to perform better than other calcium silicate-based cements except for Biodentine, which had comparable or superior results at 6 months. Meta-analyses for selected comparisons showed no significant differences in clinical and radiographic outcomes between ProRoot MTA and Biodentine over follow-up periods. The present review highlights the need for standardized definitions of success and follow-up periods in future studies to better guide clinical decisions. Despite the introduction of new calcium silicate-based cements aiming to address limitations of the original MTA. ProRoot MTA and Biodentine remain the most used and reliable materials for vital pulp therapy, although the results did not deviate that much from the other calcium silicate-based cements. Further long-term studies are required to establish the optimal CSC for each clinical scenario in both dentitions.
Low-Cycle Fatigue Damage Mechanism and Life Prediction of High-Strength Compacted Graphite Cast Iron at Different Temperatures
Authors: Wu Qihua , Tan Bingzhi , Pang Jianchao , Shi Feng , Jiang Ailong , Zou Chenglu , Zhang Yunji , Li Shouxin , Zhang Yanyan , Li Xiaowu , Zhang Zhefeng
Published: August 2024

Tensile and low-cycle fatigue tests of high-strength compacted graphite cast iron (CGI, RuT450) were carried out at 25 °C, 400 °C, and 500 °C, respectively. The results show that with the increase in temperature, the tensile strength decreases slowly and then decreases rapidly. The fatigue life decreases, and the life reduction increases at high temperature and high strain amplitude. The oxide layer appears around the graphite and cracks at high temperature, and the dependence of crack propagation on ferrite gradually decreases. With the increase in strain amplitude, the initial cyclic stress of compacted graphite cast iron increases at three temperatures, and the cyclic hardening phenomenon is obvious. The fatigue life prediction method based on the energy method and damage mechanism for compacted graphite cast iron is summarized and proposed after comparing and analyzing a large amount of fatigue data.
Tuning the Properties of Polyvinylidene Fluoride/Alkali Lignin Membranes to Develop a Biocatalytic Membrane Reactor for an Organophosphorus Pesticide Degradation
Authors: Regina Serena , Vitola Giuseppe , Mazzei Rosalinda , Giorno Lidietta
Published: August 2024

It has been observed that the immobilization of a phosphotriesterase enzyme (PTE) onto polyvinylidene fluoride (PVDF) membranes significantly decreased the enzyme activity, and this negative effect was attributed to the hydrophobic character of the membrane. The indirect indication of this reason was that the same enzyme immobilized on other membrane materials bearing hydrophilic character showed better performance. In this work, we provide direct evidence of the mechanism by immobilizing a PTE on a PVDF membrane hydrophilized by blending it with alkali lignin (AL). The PTE was immobilized on PVDF membrane by a covalent bond with the same procedure used in earlier studies to attribute changes in enzyme activity solely to the wettability properties (and not to the material chemistry). The activity of the PTE immobilized on the PVDF membrane hydrophilized with AL was 50% higher than that of the enzyme immobilized on the PVDF hydrophobic membrane. Further improvements of the membrane structure tailored for the development of a biocatalytic membrane reactor (BMR) were also promoted. In particular, the performance of the BMR was studied as a function of the thickness of the membrane, which allowed us to modulate the residence time into the enzyme-loaded membrane pores while maintaining the flow rate through the pores at a constant.
Magnetic Indicator for Evaluating Cu Clustering and Hardening Effect in RPV Model Alloy
Authors: Jia Wenqing , Quan Qiwei , Qian Wangjie , Bian Chuang , Xu Chaoliang , Yin Jian , Li Bin , Li Yuanfei , Fan Minyu , Liu Xiangbing , Wang Haitao
Published: August 2024

The reactor pressure vessel (RPV) is a critical barrier in nuclear power plants, but its embrittlement during service poses a significant safety challenge. This study investigated the effects of Cu-enriched clusters on the mechanical and magnetic properties of Fe-0.9 wt.%Cu model alloys through thermal aging. Using Vickers hardness tests, Magnetic Barkhausen Noise (MBN) detection, and Atom Probe Tomography (APT), the study aimed to establish a quantitative correlation between MBN signals, Vickers hardness, and Cu-enriched clusters, facilitating the non-destructive testing of RPV embrittlement. Experimental results showed that the hardness and MBN parameters (RMS and Vpp values) changed significantly with aging time. The hardness increased rapidly in the early stage (under-aged), followed by a plateau and then a decreasing trend (over-aged). In contrast, MBN parameters decreased initially and then increased. APT analysis revealed that Cu-enriched clusters increase in size to 4.60 nm and coalesced during aging, with their number density peaking to 3.76 × 1023 m−3 before declining. An inverse linear correlation was found between MBN signals and the combined factor Nd2Rg (product of the number density squared and the mean radius of Cu-enriched clusters). This correlation was consistent across both under-aged and over-aged states, suggesting that MBN signals can serve as applicable indicators for the non-destructive evaluation of RPV steel embrittlement.
First-Principle Study on Tailoring the Martensitic Transformation of B2 Nb50−xTixRu50 Shape-Memory Alloy for Structural Applications
Authors: Nkomo Duduzile , Shen Yu-Nien , Mostert Roelf , Yamabe-Mitarai Yoko , Phasha Maje
Published: August 2024

NbRu has a potential as a high-temperature shape-memory alloy (HTSMA) because it has a martensitic transformation temperature above 1000 °C. However, its shape-memory properties could be improved for consideration in the aerospace and automotive industry. The unsatisfactory shape-memory properties could be associated with the presence of a brittle tetragonal L10 martensitic phase. Therefore, in an attempt to modify the transformation path from B2→L10 in preference of either B2→orthorhombic or B2→monoclinic (MCL), an addition of B2 phase stabiliser, titanium (Ti), has been considered in this study to partially substitute niobium (Nb) atoms. The ab initio calculations have been conducted to investigate the effect of Ti addition on the thermodynamic, elastic, and electronic properties of the Nb50−xTixRu50 in B2 and L10 phases. The results showed that the B2 and L10 phases had comparable stability with increasing Ti content. The simulated data presented here was sufficient for the selection of suitable compositions that would allow the L10 phase to be engineered out. The said composition was identified within 15–30 at.% Ti. These compositions have a potential to be considered when designing alloys for structural application at high temperatures above 200 °C.
Effect of Cu–Al Ratio on Microstructure and Mechanical Properties of Cu–Al Alloys Prepared by Powder Metallurgy
Authors: Wang Yuze , Wu Zhiyuan , Zuo Lijie , Zhang Hongliang , He Yiqiang , Luo Yi , Liu Chang , Qian Zechen , Zou Changfang , Yu Hongmiao
Published: August 2024

Cu–Al alloys are widely used in electronics, new energy, and other fields due to the combination of th excellent corrosion resistance and electrical conductivity of Cu and the light weight of Al. In this paper, the powder metallurgy and equal-channel angular pressing compound technology was used to fabricate a Cu–Al alloy joint, which can be used to replace armor. Devices such as an optical microscope, electron scanning microscope, and microhardness scale were used to characterize the microstructure and mechanical properties of the Cu–Al alloys. The finite element analysis software Abaqus was used to analyze stress distribution during equal-channel angular pressing. The results indicated that the microstructure and properties of Cu–Al alloys were closely related to the volume ratio of Cu–Al. The microhardness and tensile strength were significantly increased by increasing the volume ratio of Cu–Al. As the volume ratio of Cu–Al varied from 1:2 to 2:1, the ultimate tensile strength of the Cu–Al alloys increased from 79.9 MPa to 164.9 MPa at room temperature and the microhardness increased from 60 HV to 101 HV. However, the elongation of the Cu–Al alloys hardly changed; this was about 4.4%. Crack initiation occurred at the Cu–Al interface and spread along the bonding surface of the Cu–Al alloys during the tensile process.
Study on the Surface Quality of Overhanging Holes Fabricated by Additive/Subtractive Hybrid Manufacturing for Ti6Al4V Alloy
Authors: Liu Yanmei , Liu Weijian , Zhang Yingwei , Guan Feng , Xue Xiong , Zheng Yongsheng , Bai Qian
Published: August 2024

Additive/subtractive hybrid manufacturing (ASHM) based on laser powder bed fusion (LPBF) enables to achieve high precision and good surface quality of complex structures such as small holes with overhanging features. However, the rapid heating and cooling rates during the ASHM results in sinkage at the alternating interface of additive manufacturing and subtractive milling, which degrades the surface quality of the components. This study employs shielding height at the alternating interface to solve this problem and improve the surface quality. The effect of internal diameters and shielding heights on the surface quality were studied experimentally for overhanging holes fabricated by ASHM of Ti6Al4V. The results show that the Ti6Al4V samples prepared by LPBF possessed high density and uniformly distributed microstructure. For overhanging holes without shielding height, the largest depth value of sinkage and surface roughness were obtained, indicating a worse surface quality; when the shielding height was increased to 0.5 mm, the smallest sinkage value and surface roughness were obtained, indicating a better surface quality. With the same shielding height, the overhanging holes with different diameters had a similar surface roughness. This study reveals that an appropriate shielding height can improve the surface quality, which provides guidance to the improvement of the surface quality for complex structures in ASHM.
Temperature Effects in Packaged RF MEMS Switches with Optimized Gold Electroplating Process
Authors: Wang Lifeng , Jiang Lili , Ma Ning , Huang Xiaodong
Published: August 2024

Due to its excellent electrical performance, mechanical reliability, and thermal stability, electroplated gold is still the most commonly used material for movable beams in RF MEMS switches. This paper investigates the influence of process conditions on the quality and growth rate of gold electroplating, and the optimized process parameters for the gold electroplating process are obtained. The characterization of the optimized electroplated gold layer shows that it has small surface roughness and excellent thermal stability. With this optimized gold electroplating process, the RF MEMS switches are fabricated and hermetic packaged. In order to obtain the temperature environment adaptability of the packaged switch, the influence of working temperature is studied. The temperature effects on mechanical performance (includes pull-in voltage and lifetime) and RF performance (includes insertion loss and isolation) are revealed.
Salvia elegans Vahl Counteracting Metabolic Syndrome and Depression in Mice on a High-Fat Diet
Authors: Martínez-Hernández Gabriela Belen , Jiménez-Ferrer Enrique , González-Cortazar Manases , Alejandro Zamilpa , Monterrosas-Brisson Nayeli , Herrera-Ruiz Maribel
Published: August 2024

Salvia elegans Vahl is a plant commonly used in Mexico as a remedy for nervous disorders, inflammatory diseases, and “ringing in the ears”; the latter can be associated with arteriosclerotic conditions and arterial hypertension. Therefore, based on medicinal use, this work aimed to evaluate the hydroalcoholic extract (SeHA, 100 mg/kg) of this plant and two fractions, ethyl acetate (SeFAc, 50 mg/kg), and obtained from SeFAc fractionation denominated SeF3 (10 mg/kg), on several alterations derived from metabolic syndrome (MetS) derived from the ingestion of a high-calorie diet (high-fat diet), in ICR (Institute of Cancer Research) mice, leading to chronic inflammation that results in neurological damage such as depression. Therefore, several MetS-related parameters, such as forced swim tests, hypertension, serum corticosterone levels, glucose, triglycerides, cholesterol, adiposity index, and insulin resistance, will be evaluated. Additionally, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-10 levels were measured in kidneys, fat tissue, brains, and spleens. It was proven that all those S. elegans-derived treatments reversed the damage, showing antidepressant, antihypertensive, antihyperglycemic, and antidyslipidemic effects and decreased adiposity, insulin resistance, and serum corticosterone. They induced a modulatory response by modifying the levels of TNF-α, IL-1β, IL-6, and IL-10 in different organs. High-performance liquid chromatography (HPLC) analysis of the acetate of ethyl fraction from S. elegans (SeFAc) fraction revealed the presence of rosmarinic and caffeic acids as well as flavonoids, while the fraction from SeFAc called SeF3 Was identified by gas mass as methyl glucose, glycerol, and known sterols, among others. Thus, it was concluded that S. elegans protects against the harmful effects of MetS.
Effect of Tourmaline Addition on the Anti-Poisoning Performance of MnCeOx@TiO2 Catalyst for Low-Temperature Selective Catalytic Reduction of NOx
Authors: Zhao Zhenzhen , Wang Liyin , Lin Xiangqing , Xue Gang , Hu Hui , Ma Haibin , Wang Ziyu , Su Xiaofang , Gao Yanan
Published: August 2024

In view of the flue gas characteristics of cement kilns in China, the development of low-temperature denitrification catalysts with excellent anti-poisoning performance has important theoretical and practical significance. In this work, a series of MnCeOx@TiO2 and tourmaline-containing MnCeOx@TiO2-T catalysts was prepared using a chemical pre-deposition method. It was found that the MnCeOx@TiO2-T2 catalyst (containing 2% tourmaline) exhibited the best low-temperature NH3-selective catalytic reduction (NH3-SCR) performance, yielding 100% NOx conversion at 110 °C and above. When 100–300 ppm SO2 and 10 vol.% H2O were introduced to the reaction, the NOx conversion of the MnCeOx@TiO2-T2 catalyst was still higher than 90% at 170 °C, indicating good anti-poisoning performance. The addition of appropriate amounts of tourmaline can not only preferably expose the active {001} facets of TiO2 but also introduce the acidic SiO2 and Al2O3 components and increase the content of Mn4+ and Oα on the surface of the catalyst, all of which contribute to the enhancement of reaction activity of NH3-SCR and anti-poisoning performance. However, excess amounts of tourmaline led to the formation of dense surface of catalysts that suppressed the exposure of catalytic active sites, giving rise to the decrease in catalytic activity and anti-poisoning capability. Through an in situ DRIFTS study, it was found that the addition of appropriate amounts of tourmaline increased the number of Brønsted acid sites on the catalyst surface, which suppressed the adsorption of SO2 and thus inhibited the deposition of NH4HSO4 and (NH4)2HSO4 on the surface of the catalyst, thereby improving the NH3-SCR performance and anti-poisoning ability of the catalyst.
Thevetia thevetioides Cardenolide and Related Cardiac Glycoside Profile in Mature and Immature Seeds by High-Resolution Thin-Layer Chromatography (HPTLC) and Quadrupole Time of Flight–Tandem Mass Spectrometry (Q-TOF MS/MS) Reveals Insights of the Cardenolide Biosynthetic Pathway
Authors: Vázquez-Martínez Juan , Bravo-Villa Paulina , Molina-Torres Jorge
Published: August 2024

Thevetia thevetioides is a species within the Apocynaceae family known for containing cardenolide-glycosides, commonly referred to as cardiac glycosides, which are characteristic of this genus. The seeds of the Thevetia species are frequently used as a model source for studying cardiac steroids, as these glycosides can be more readily extracted from the oil-rich seeds than from the plant’s green tissues. In this work, the cardenolide profile of ripe and immature seeds was determined and compared to establish the main differences. Ripe seeds contain six related cardenolides and triosides, with thevetin B being the predominant component. In contrast, immature seeds exhibit a total of thirteen cardiac glycosides, including monoglycosides such as neriifolin and peruvosides A, B, and C, as well as diglycosides like thevebiosides A, B, and C. Some of these compounds have previously been identified as degradation products of more complex cardiac glycosides; however, their presence in immature seeds, as described in this study, suggests that they may serve as biosynthetic precursors to the triosides observed in mature seeds. The glycoside patterns observed via HPTLC are associated with specific chemical structures characteristic of this genus, typically featuring thevetose or acetyl-thevetose at the first position, followed by glucose or gentibiose in di- or trisaccharides, independent of the trioside aglycones identified: digitoxigenin, cannogenin, or yccotligenin. Ripe seeds predominantly contain triosides, including thevetin B, C, and A, the latter of which has not been previously reported.
Mechanism of Carrier Formation in P3HT-C60-PCBM Solar Cells
Authors: Tachikawa Hiroto , Kawabata Hiroshi , Abe Shigeaki , Watanabe Ikuya
Published: August 2024

Solar cells convert light energy directly into electricity using semiconductor materials. The ternary system, composed of poly(3-hexylthiophene) (P3HT), fullerene (C60), and phenyl-C61-butyric-acid-methyl-ester (PCBM), expressed as P3HT-C60-PCBM, is one of the most efficient organic solar cells. In the present study, the structures and electronic states of P3HT-C60-PCBM have been investigated by means of the density functional theory (DFT) method to shed light on the mechanism of charge separation in semiconductor materials. The thiophene hexamer was used as a model of P3HT. Five geometrical conformers were obtained as the C60-PCBM binary complexes. In the ternary system, P3HT wrapped around C60 in the stable structure of P3HT-C60-PCBM. The intermolecular distances for P3HT-(C60-PCBM) and (P3HT-C60)-PCBM were 3.255 and 2.885 Å, respectively. The binding energies of P3HT + (C60-PCBM) and (P3HT-C60) + PCBM were 27.2 and 19.1 kcal/mol, respectively. The charge transfer bands were found at the low-lying excited states of P3HT-C60-PCBM. These bands strongly correlated with the carrier separation and electron transfer in solar cells. The electronic states at the ground and excited states of P3HT-C60-PCBM were discussed on the basis of the calculated results.
Two-Dimensional Semiconductors for State-of-the-Art Complementary Field-Effect Transistors and Integrated Circuits
Authors: Liang Meng , Yan Han , Wazir Nasrullah , Zhou Changjian , Ma Zichao
Published: August 2024

As the trajectory of transistor scaling defined by Moore’s law encounters challenges, the paradigm of ever-evolving integrated circuit technology shifts to explore unconventional materials and architectures to sustain progress. Two-dimensional (2D) semiconductors, characterized by their atomic-scale thickness and exceptional electronic properties, have emerged as a beacon of promise in this quest for the continued advancement of field-effect transistor (FET) technology. The energy-efficient complementary circuit integration necessitates strategic engineering of both n-channel and p-channel 2D FETs to achieve symmetrical high performance. This intricate process mandates the realization of demanding device characteristics, including low contact resistance, precisely controlled doping schemes, high mobility, and seamless incorporation of high- κ dielectrics. Furthermore, the uniform growth of wafer-scale 2D film is imperative to mitigate defect density, minimize device-to-device variation, and establish pristine interfaces within the integrated circuits. This review examines the latest breakthroughs with a focus on the preparation of 2D channel materials and device engineering in advanced FET structures. It also extensively summarizes critical aspects such as the scalability and compatibility of 2D FET devices with existing manufacturing technologies, elucidating the synergistic relationships crucial for realizing efficient and high-performance 2D FETs. These findings extend to potential integrated circuit applications in diverse functionalities.
Optimum Design of InGaN Blue Laser Diodes with Indium-Tin-Oxide and Dielectric Cladding Layers
Authors: Onwukaeme Chibuzo , Ryu Han-Youl
Published: August 2024

The efficiency of current GaN-based blue laser diodes (LDs) is limited by the high resistance of a thick p-AlGaN cladding layer. To reduce the operation voltage of InGaN blue LDs, we investigated optimum LD structures with an indium tin oxide (ITO) partial cladding layer using numerical simulations of LD device characteristics such as laser power, forward voltage, and wall-plug efficiency (WPE). The wall-plug efficiency of the optimized structure with the ITO layer was found to increase by more than 20% relative to the WPE of conventional LD structures. In the optimum design, the thickness of the p-AlGaN layer decreased from 700 to 150 nm, resulting in a significantly reduced operation voltage and, hence, increased WPE. In addition, we have proposed a new type of GaN-based blue LD structure with a dielectric partial cladding layer to further reduce the optical absorption of a lasing mode. The p-cladding layer of the proposed structure consisted of SiO2, ITO, and p-AlGaN layers. In the optimized structure, the total thickness of the ITO and p-AlGaN layers was less than 100 nm, leading to significantly improved slope efficiency and operation voltage. The WPE of the optimized structure was increased relatively by 25% compared to the WPE of conventional GaN-based LD structures with a p-AlGaN cladding layer. The investigated LD structures employing the ITO and SiO2 cladding layers are expected to significantly enhance the WPE of high-power GaN-based blue LDs.
Low-Mineral Water Diminishes the Bone Benefits of Boron
Authors: Huang Ting , Hao Yuhui , Tan Yao , Dai Qijie , Chen Weiyan , Cui Ke , Luo Jiaohua , Zeng Hui , Shu Weiqun , Huang Yujing
Published: August 2024

This study looked at how desalinated seawater, which has low minerals and high boron, could affect bone health. Prior research suggests that low mineral water may harm bone health and boron could be beneficial, but the overall impact on bone health is still unclear. Eighty-nine-week-old male Balb/C mice were allocated into eight groups and administered either tap water or purified water with varying boron concentrations (0, 5, 40, and 200 mg/L). They were kept in an environment mimicking tropical conditions (35–40 °C, 70–80% humidity) and underwent daily treadmill exercise for 13 weeks. At the 14th week, serum, femora, and lumbar vertebrae were collected for mineral metabolism, bone biomarker, microstructure, and biomechanics evaluation. Boron exposure improved bone formation, microstructure, and biomechanics initially but the benefits weakened with higher levels of exposure (p < 0.05). Co-exposure to purified water elevated serum boron but weakened the promotion of boron on bone minerals and the bone benefits of boron compared to tap water (p < 0.05). Thus, when studying the health effects of boron in desalinated seawater, it is crucial to look at various health effects beyond bone health. Furthermore, it is important to consider the mineral composition of drinking water when using boron for bone health benefits.
Subcutaneous Semaglutide during Breastfeeding: Infant Safety Regarding Drug Transfer into Human Milk
Authors: Diab Hanin , Fuquay Taylor , Datta Palika , Bickel Ulrich , Thompson Jonathan , Krutsch Kaytlin
Published: August 2024

Postpartum mothers and their healthcare providers often face the challenge of limited data regarding the safety of drug therapies during lactation. Pregnancy can lead to sustained weight gain, and obesity can negatively impact both physical and psychological well-being. The introduction of GLP-1 agonists to augment weight loss has become a topic of interest for many postpartum mothers. Our study aims to investigate the transmission of semaglutide into human milk in the first steps to ensure the safety and health of both lactating mothers and their breastfed infants. Semaglutide quantification was performed using high-resolution liquid chromatography-mass spectrometry. InfantRisk Center Human Milk biorepository released milk samples from eight women collected at 0, 12 and 24 h post-semaglutide administration. Semaglutide was extracted using protein precipitation in methanol, followed by chromatographic separation. Linear calibration curves for the method ranged between 2.5–30 ng/mL, with a limit of detection of 1.7 ng/mL and a limit of quantification of 5.7 ng/mL (LLOQ). Semaglutide was not detected in any of the collected human milk samples. A worst-case scenario of the relative infant dose (RID) was calculated using the LLOQ as the drug concentration in milk when considering semaglutide’s bioavailability and long-acting dose profile. The maximum RID projected was 1.26%, far below the standard 10% safety threshold. While questions about long-term infant outcomes, the safety of maternal nutrient intake, and the nutrient content of breast milk remain, our findings suggest that semaglutide concentrations in human milk are unlikely to pose clinical concerns for breastfed infants. These results support healthcare providers in making informed decisions regarding postpartum therapeutic interventions.
Insights into Asparaginase Allergic Responses: Exploring Pharmacogenetic Influences
Authors: Cecconello Daiane Keller , Silva Klerize Anecely de Souza , de Senna Evelin Cristine Mendonça , Rechenmacher Ciliana , Daudt Liane Esteves , Michalowski Mariana Bohns
Published: August 2024

Acute lymphoblastic leukemia represents the most prevalent childhood cancer. Modern chemotherapy has significantly improved outcomes, achieving EFS rates of 80% and OS rates nearing 90% in developed nations, while in developing regions, rates remain below 50%, highlighting disparities, and this difference is due to several factors. Genetic variability plays a role in these drug response disparities, presenting single-nucleotide variations (SNVs). Pharmacogenetic research aims to pinpoint these SNVs early in treatment to predict specific drug responses effectively. This review aims to explore advancements in pharmacogenetics associated with asparaginase (ASNase). ASNase plays a crucial role in the treatment of ALL and is available in three formulations: E. coli, Erwinia, and PEG ASNase. ASNase therapy presents challenges due to adverse effects, like hypersensitivity reactions. Identifying predictive markers for hypersensitivity development beforehand is crucial for optimizing treatments. Several pharmacogenetic studies have investigated the association between SNVs and the risk of hypersensitivity. Key genes include GRIA1, NFATC2, CNTO3, ARHGAP28, MYBBP1A, and HLA. Studies have highlighted associations between SNVs within these genes and hypersensitivity reactions. Notably, most pharmacogenetic investigations of hypersensitivity have focused on patients treated with E. coli, emphasizing the need for broader exploration across different formulations. Future research investigating these variants holds promise for advancing our understanding of ASNase’s pharmacogenetics.
Development of Simultaneous Drug Concentration Measurement Method Using an Automated Pretreatment Liquid Chromatography/Tandem Mass Spectrometry System for Therapeutic Drug Monitoring
Authors: Sato Yu , Kondo Hiroki , Sato Yuji , Abe Ai , Kikuchi Masafumi , Sato Toshihiro , Kumondai Masaki , Yoshikawa Kohei , Hayakawa Yoshihiro , Maekawa Masamitsu , Mano Nariyasu
Published: August 2024

Therapeutic drug monitoring (TDM) is a personalized treatment approach that involves optimizing drug dosages based on patient-specific factors, such as drug plasma concentrations, therapeutic efficacy, or adverse reactions. The plasma concentration of drugs is determined using liquid chromatography/tandem mass spectrometry (LC-MS/MS) or various immunoassays. Compared with immunoassays, LC-MS/MS requires more pretreatment time as the number of samples increases. Recently, fully automated pretreatment LC-MS/MS systems have been developed to automatically perform whole-sample pretreatment for LC-MS/MS analysis. In this study, we developed a method for simultaneous concentration determination of five analytes (clozapine, mycophenolic acid, sunitinib, N-desethylsunitinib, and voriconazole) using LC-MS/MS for clinical TDM using a fully automated LC-MS/MS pretreatment system. In the developed method, the intra- and inter-assay relative error (RE) values ranged between −14.8% and 11.3%; the intra- and inter-assay coefficient of variation (CV) values were <8.8% and <10.5%, respectively. The analytes showed good stability, with RE values ranging between −13.6% and 10.9% and CV values <8.9%. Furthermore, the plasma concentrations in clinical samples using this method and the conventional manual pretreatment method showed similar results. Therefore, the method developed in this study could be considered a useful pretreatment method for routine TDM in patients.
Contractile Effects of Semaglutide in the Human Atrium
Authors: Neumann Joachim , Hadová Katarína , Klimas Jan , Hofmann Britt , Gergs Ulrich
Published: August 2024

Semaglutide is a glucagon-like peptide 1 receptor (GLP-1R) agonist. GLP-1R agonists are used to treat type 2 diabetes and obesity. It is currently unknown whether semaglutide can directly increase force of contraction (FOC) in the human heart. We tested the hypothesis that semaglutide might increase the FOC in the isolated human atrium. To this end, we conducted contraction experiments in isolated human right atrial muscle preparations (HAP). HAP were obtained during open-heart surgery. We detected a concentration- and time-dependent positive inotropic effect (PIE) of semaglutide in HAP. These PIEs were accompanied by increases in the rates of tension development and tension relaxation and a reduction in muscle relaxation time. The PIE of semaglutide in HAP was attenuated by H89, an inhibitor of the cyclic AMP-dependent protein kinase and by ryanodine, an inhibitor of sarcoplasmic Ca2+ release. Semaglutide up to 100 nM failed to exert a PIE in isolated electrically paced (1 Hz) wild-type mouse left atrial preparations studied for comparison. Our data suggest that semaglutide can increase the FOC in the atria of patients at therapeutic drug concentrations.
A Three-Dimensional Reconstruction Method Based on Telecentric Epipolar Constraints
Authors: Li Qinsong , Ge Zhendong , Yang Xin , Zhu Xianwei
Published: August 2024

When calibrating a microscopic fringe projection profile system with a telecentric camera, the orthogonality of the camera causes an ambiguity in the positive and negative signs of its external parameters. A common solution is to introduce additional constraints, which often increase the level of complexity and the calibration cost. Another solution is to abandon the internal/external parameter models derived from the physical imaging process and obtain a numerically optimal projection matrix through the least squares solution. This paper proposes a novel calibration method, which derives a telecentric epipolar constraint model from the conventional epipolar constraint relationship and uses this constraint relationship to complete the stereo calibration of the system. On the one hand, since only the camera’s intrinsic parameters are needed, there is no need to introduce additional constraints. On the other hand, the solution is optimized based on the full consideration of the imaging model to make the parameters confirm to the physical model. Our experiments proved the feasibility and accuracy of the method.
Zn-Al Ferrite/Polypyrrole Nanocomposites: Structure and Dielectric and Magnetic Properties for Microwave Applications
Authors: Khalil Huda F. , Elsharkawy Sherif G. , AL-Harby Nouf F. , El-Batouti Mervette
Published: August 2024

In this study, Zn-Al ferrite/polypyrrole (PPy) nanocomposites were synthesized and thoroughly characterized to explore their potential for microwave applications. X-ray diffraction analysis confirmed the presence of ZnO, AlFeO3, and Fe2O3 phases, with the crystal size decreasing from 31 nm to 19.6 nm as aluminum content increased. High-resolution transmission electron microscopy (HR-TEM) revealed a distinctive core–shell morphology, where the polypyrrole encapsulates the ZnAlxFe2−xO4 particles. Magnetic measurements showed that decreasing aluminum concentration led to a reduction in both saturation magnetization (Ms) from 75 emu/g to 36 emu/g and remanent magnetization (Mr) from 2.26 emu/g to 2.00 emu/g. Dielectric analysis indicated that both the real (ε′) and imaginary (ε″) components of dielectric permittivity decreased with increasing frequency, particularly between 10 and 14 GHz. Furthermore, electrical modulus analysis highlighted the significant impact of aluminum doping on relaxation time (τIP), indicating the presence of interface polarization. Impedance spectroscopy results underscored the dominance of interface polarization at lower frequencies and the presence of strong conduction paths at higher frequencies. These combined magnetic and dielectric loss mechanisms suggest that the Zn-Al ferrite/polypyrrole nanocomposite is a promising candidate for advanced microwave absorption applications.
Molecular Imprinting Technology for Advanced Delivery of Essential Oils
Authors: Kaspute Greta , Ramanavicius Arunas , Prentice Urte
Published: August 2024

Essential oils (EOs) hold therapeutic potential, but their conventional delivery systems have some limitations. This review focuses on the critical review and discussion of research related to EO delivery systems. The review also explores how molecular imprinting technologies (MIT) can advance EO delivery. MIT offer several techniques, namely covalent, non-covalent, and semi-covalent imprinting, creating targeted cavities that selectively bind and release EOs. These approaches promise significant advantages including increased selectivity, controlled release, and protection from environmental degradation. However, some challenges related to the stability and biocompatibility of MIPs remain unsolved. Integrating nanotechnology through methods like nanoparticle imprinting and some lithographic techniques seems promising to overcome these limitations. Some recently established models and systems used for EO-related research are paving the way for a more efficient and targeted EO delivery approach to harnessing the therapeutic power of EOs. Therefore, some recent and future research seems promising, and eventually it will increase the effectiveness of MIP-based EO delivery systems.
An Improved Average Acceleration Approach of Modelling Earth Gravity Field Based on K-Band Range-Rate Observations
Authors: Tan Xuli , Fan Diao , Feng Jinkai , Wan Hongfa , Xu Zhenbang , Li Shanshan
Published: August 2024

The conventional average acceleration approach relies on K-band range observation, containing an unknown bias, which leads to possible degradation of the precision of Earth’s gravity field modelling. It also suffers from correlated errors caused by three-point numerical differentiation. In this study, an improved approach is proposed that makes use of K-band range-rate observations instead and overcoming the influence of correlated errors by introducing a whitening filter. GRACE-Follow On data spanning the period from January 2019 to December 2022 were processed by the proposed approach and a series of time-varying gravity field models was derived, referred to as SSM-AAA-GFO in this paper. This model series is compared comprehensively with three official model series. Results demonstrate that all model series are highly coincident below degree 30 and reflect similar time-varying gravity field signals in both large and small basins. After filtering, SSM-AAA-GFO shows uncertainty, in the form of equivalent water height below 2.5 cm, which is comparable with three official model series. The comparison results confirm the effectiveness of the proposed approach for precisely modelling a time-varying gravity field based on K-band range-rate observations.
Auroral Image Classification Based on Second-Order Convolutional Network and Channel Attention Awareness
Authors: Hu Yangfan , Zhou Zeming , Yang Pinglv , Zhao Xiaofeng , Li Qian , Zhang Peng
Published: August 2024

Accurate classification of ground-based auroral images is essential for studying variations in auroral morphology and uncovering magnetospheric mechanisms. However, distinguishing subtle morphological differences among different categories of auroral images presents a significant challenge. To excavate more discriminative information from ground-based auroral images, a novel method named learning representative channel attention information from second-order statistics (LRCAISS) is proposed. The LRCAISS is highlighted with two innovative techniques: a second-order convolutional network and a novel second-order channel attention block. The LRCAISS extends from Resnet50 architecture by incorporating a second-order convolutional network to capture more detailed statistical representation. Meanwhile, the novel second-order channel attention block effectively recalibrates these features. LACAISS is evaluated on two public ground-based auroral image datasets, and the experimental results demonstrate that LRCAISS achieves competitive performance compared to existing methods.
Auto-Scaling Techniques in Cloud Computing: Issues and Research Directions
Authors: Alharthi Saleha , Alshamsi Afra , Alseiari Anoud , Alwarafy Abdulmalik
Published: August 2024

In the dynamic world of cloud computing, auto-scaling stands as a beacon of efficiency, dynamically aligning resources with fluctuating demands. This paper presents a comprehensive review of auto-scaling techniques, highlighting significant advancements and persisting challenges in the field. First, we overview the fundamental principles and mechanisms of auto-scaling, including its role in improving cost efficiency, performance, and energy consumption in cloud services. We then discuss various strategies employed in auto-scaling, ranging from threshold-based rules and queuing theory to sophisticated machine learning and time series analysis approaches. After that, we explore the critical issues in auto-scaling practices and review several studies that demonstrate how these challenges can be addressed. We then conclude by offering insights into several promising research directions, emphasizing the development of predictive scaling mechanisms and the integration of advanced machine learning techniques to achieve more effective and efficient auto-scaling solutions.
Robotic Valve Turning with a Wheeled Mobile Manipulator via Hybrid Passive/Active Compliance
Authors: Xing Hongjun , Ding Liang , Chen Jinbao , Gao Haibo , Deng Zongquan
Published: August 2024

This paper addresses the problems of valve-turning operation in rescue environments where a wheeled mobile manipulator (WMM) is employed, including the possible occurrence of large internal forces. Rather than attempting to obtain the exact position of the valve, this paper presents a solution to two main problems in robotic valve-turning operations: the radial position deviation between the rotation axes of the tool and the valve handle, which may cause large radial forces, and the possible axial displacement of the valve handle as the valve turns, which may lead to large axial forces. For the former problem, we designed a compliant end-effector with a tolerance of approximately 3.5° (angle) and 9.7 mm (position), and provided a hybrid passive/active compliance method. For the latter problem, a passivity-based force tracking algorithm was employed. Combining the custom-built compliant end-effector and the passivity-based control method can significantly reduce both the radial and the axial forces. Additionally, for valves with different installation types and WMMs with different configurations, we analyzed the minimum required number of actuators for valve turning. Simulation and experimental results are presented to show the effectiveness of the proposed approach.
A Single-Frame and Multi-Frame Cascaded Image Super-Resolution Method
Authors: Sun Jing , Yuan Qiangqiang , Shen Huanfeng , Li Jie , Zhang Liangpei
Published: August 2024

The objective of image super-resolution is to reconstruct a high-resolution (HR) image with the prior knowledge from one or several low-resolution (LR) images. However, in the real world, due to the limited complementary information, the performance of both single-frame and multi-frame super-resolution reconstruction degrades rapidly as the magnification increases. In this paper, we propose a novel two-step image super resolution method concatenating multi-frame super-resolution (MFSR) with single-frame super-resolution (SFSR), to progressively upsample images to the desired resolution. The proposed method consisting of an L0-norm constrained reconstruction scheme and an enhanced residual back-projection network, integrating the flexibility of the variational model-based method and the feature learning capacity of the deep learning-based method. To verify the effectiveness of the proposed algorithm, extensive experiments with both simulated and real world sequences were implemented. The experimental results show that the proposed method yields superior performance in both objective and perceptual quality measurements. The average PSNRs of the cascade model in set5 and set14 are 33.413 dB and 29.658 dB respectively, which are 0.76 dB and 0.621 dB more than the baseline method. In addition, the experiment indicates that this cascade model can be robustly applied to different SFSR and MFSR methods.
Detection of Debonding Defects in Carbon Fiber-Reinforced Polymer (CFRP)–Rubber Bonded Structures Based on Active Lamb Wave Energy Analysis
Authors: Yang Zhenze , Ren Yongfeng , Shi Qiang , Cui Dapeng , Liu Jieqing
Published: August 2024

Carbon fiber-reinforced polymers (CFRPs) are widely used in the fabrication of solid rocket motor casings due to their exceptional performance. However, the bonding interface between CFRP and viscoelastic materials (rubber) is prone to debonding damage during service and storage under complex environmental conditions, which poses a significant threat to the structural integrity and reliability of the engine. Existing nondestructive testing (NDT) methods, such as X-ray imaging, infrared thermography, and ultrasonic testing, although somewhat effective, exhibit significant limitations in detecting interfacial defects in deep or multilayered composite materials, particularly under the challenging conditions of service and storage. This study proposes an innovative method based on active Lamb wave energy analysis and introduces the Damage Evolution Factor (DEF), specifically designed to detect and evaluate interfacial debonding defects in CFRP–rubber bonded structures within solid rocket motors during service and storage. Through numerical simulations and experimental validation, we selected the A0 mode Lamb wave, which is more sensitive to interfacial damage, as the incident wave and excited it on the surface of the structure. Displacement time-history response signals at observation points under different damage models were extracted and analyzed, and DEF values were calculated. The results show that DEF values increase with the size of the interfacial debonding damage. Similar trends were observed in experimental studies, further validating the effectiveness of this method and demonstrating that DEF can be used for the quantitative evaluation of interfacial debonding defects in CFRP–rubber bilayer bonded structures.