bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a spontaneous model of renal interstitial fibrosis in NOD/SCID mice: Aging-induced pathogenesis
Authors: Qiu Lihua , Ma Zhaoxia , Li Jinyan , Wu Zhen , Dai Longmei , Long Ruimin , Hu Linlin , Sun Jianxiu , Hu Min , Li Yanjiao
Published: December 2024

Renal interstitial fibrosis, a condition prevalent in aging humans and animals, is closely linked to the eventual development of renal failure. Establishing an animal model that exactly replicates the pathogenesis of renal interstitial fibrosis induced by natural aging in humans is crucial for advancing mechanistic studies and testing antifibrotic therapies. Implanted allogeneic or xenogeneic cells are cleared by the immune system when stem cell therapy is applied in nonimmunodeficient animal fibrosis models, affecting the effect of the intervention and making it difficult to demonstrate the survival, proliferation, differentiation, or secretion of the delivered autologous human-derived cells. This study effectively developed a model of spontaneous renal interstitial fibrosis linked to natural aging in 43-week-old NOD/SCID mice. Compared with those of 12- and 32-week-old mice, the kidneys of the model mice exhibited prominent fibrosis characteristics, accompanied by numerous fibrous septa and collagen deposition, increased COL1A1 expression, and decreased MMP9 expression. SA-β-gal activity and P21 gene expression levels increased, confirming renal cell senescence in the model mice. Additionally, an increase in α-SMA staining indicated an increase in epithelial–mesenchymal transition. More importantly, we observed TGF-β-SMAD3 pathway activation, mitochondrial dysfunction, decreased antioxidant capacity, oxidative stress, and an enhanced inflammatory response in the model group, consistent with renal interstitial fibrosis in elderly individuals. In this comprehensive investigation, we successfully developed a spontaneous mouse model of renal interstitial fibrosis and revealed the molecular pathways contributing to increased susceptibility to kidney injury and renal fibrosis in elderly individuals.
Evolución en la clasificación de objetos educativos a través de los catálogos de material de enseñanza en España (1880-1950)
Authors: Martínez Ruiz-Funes M José , Marín Murcia José Pedro , Amorós Poveda Lucía
Published: December 2024

Este trabajo analiza la evolución de los catálogos de material educativo y su función en la preservación del patrimonio educativo. A través del estudio de diversos catálogos, se exploran las transformaciones en la clasificación y organización de los materiales en respuesta a las demandas del sistema educativo. La propuesta de sistematización presentada busca contribuir al estudio del contexto histórico de estos materiales, ofreciendo una perspectiva que abarca múltiples disciplinas. Este enfoque permite comprender la influencia del mercado y los cambios pedagógicos en la oferta educativa a lo largo del tiempo.
Problemas externalizantes antes y después de la pandemia de COVID-19 en estudiantes del norte de Chile
Authors: Caqueo-Urízar Alejandra , Mena-Chamorro Patricio , Henríquez Diego , Urzúa Alfonso
Published: December 2024

Antecedentes: Este estudio buscó analizar las diferencias con respecto a los problemas externalizantes entre adolescentes del norte de Chile en un contexto de pandemia. Método: Se empleó un diseño transversal recurrente. La muestra estuvo constituida por 475 alumnos de establecimientos educacionales de la ciudad de Arica, con edades entre 12 y 18 años. Se midieron los problemas externalizantes de salud mental antes y después de la pandemia de COVID-19. Resultados: Los hallazgos señalan una disminución de las conductas agresivas y un aumento de los problemas de atención e hiperactividad-impulsividad. Además, las cuestiones contextuales y la pandemia de COVID-19 son factores que pueden incidir en el aumento de los problemas externalizantes, según los modelos de regresión lineal múltiple. Conclusiones: El aumento observado en algunos de los problemas externalizantes requiere mejorar la coordinación e integración de los profesionales de salud mental en las instituciones educativas.
Prevalance of Non-Provoke Generalize Tonic-Clonic Seizure in Sporadic Alzheimer’s Disease
Authors: Varlibas Figen Bakici , Domac Fusun Mayda , Yuksel Gulbun , Akhan Ozkan , Ercin Elif
Published: December 2024

Background and Purpose: Alzheimer’s disease (AD) and epileptic seizure are among the most common health problems in the elderly population. This study aimed to estimate the prevalence rate and predictors of seizures in sporadic AD patients.Methods: The study was conducted by retrospectively for a period of 10 years examining the file records. Patients were selected among the patients diagnosed with probable sporadic late onset AD according to the National Institute of Neurological Communicative Disorders and Stroke AD and related disorders association criteria and the diagnostic and statistical manual of mental disorders (n=451). In our 213 sporadic AD patients who were followed up regularly and had a follow up examination in the last 6 months, the file records were examined, scanned and questioned for the presence of epileptic seizures.Results: The prevalence of non provoked generalized tonic clonic seizures in sporadic AD was found to be 6.57% (n=14). Neuroleptic use, presence of diabetes mellitus (DM) and/or treatment, presence of ischemic heart disease (IHD) and/or treatment were found to be 2.99 times, 1.91 times and 3.09 times higher in our patients who had seizures, respectively. When the factors that can affect seizures were examined, the use of neuroleptics and the presence of IHD and/or treatment were found to be statistically significant in terms of the risk of seizure in AD.Conclusions: The use of neuroleptics, the presence of IHD and DM and/or their medications could facilitate the development of unprovoked generalized tonic clonic seizures in sporadic AD. It is doubtful whether the seizures are primary or secondary generalized.
Effect of Anti-Seizure Medication Monotherapy on Vitamin D Levels in Indian Children: A Longitudinal Cohort Study
Authors: Behera Shatrishna , Mishra Devendra , Mahajan Bhawna , Mantan Mukta , Bansal Shubham
Published: December 2024

Background and Purpose: The timeline of alteration of vitamin D and calcium levels in those receiving anti-seizure medication (ASM) remains to be elucidated. To determine the changes in vitamin D levels over a period of 6 months among children receiving monotherapy with commonly used ASM.Methods: The baseline serum levels of vitamin D, parathyroid hormone (PTH), calcium, alkaline phosphatase (ALP), phosphorus were measured in 32 children (median age 8 years) with newly diagnosed epilepsy. An appropriate ASM monotherapy was started. Those found to be deficient were treated with vitamin D supplementation. Children were reassessed after 90 days and 180 days for drug compliance and drug side-effects. All the baseline investigations were repeated.Results: At baseline, 21.9% of children were vitamin D-deficient, with a median serum level of 19.8 ng/mL. For children who were not vitamin D-deficient (VDD) at baseline (n=25), the median (interquartile range [IQR]) vitamin D levels were found to be significantly lower than baseline after 90 days of ASM use (23.0 [18.0 to 28.9] vs. 22.0 [12.0 to 24.0]; p<0.001). After 90 days, ASMs caused notable decreases in vitamin D levels from baseline for children who were not VDD at baseline (n=25) (23.0 [18.0 to 28.9] vs. 22.0 [12.0 to 24.0]; p<0.001), alongside changes in calcium, phosphorus, PTH and ALP levels. Similarly, in children who were non-deficient at 90 days follow-up (n=20), median (IQR) vitamin D levels were found to be significantly lower at 180 days than at 90 days (24.5 [21.0 to 28.9] vs. 18.4 [13.6 to 20.6]; p<0.001).Conclusions: The study noted vitamin D deficiency in children on ASM monotherapy for 3-6 months, emphasizing regular monitoring by clinicians.
The Use of Perampanel in the Treatment of Lance-Adams Syndrome
Authors: Pandya Vishal , Husari Khalil S.
Published: December 2024

Lance Adams syndrome (LAS) is characterized by chronic action or intention myoclonus resulting from cerebral hypoxia. Perampanel, a non-competitive antagonist of aamino-3-hydroxy-5methyl-4 isooxazoleproprionic acid glutamate receptor, has demonstrated some efficacy in myoclonic epilepsy and other types of myoclonus. We report significant benefit in a patient with LAS treated with add on perampanel and provide a review of the relevant literature. In our case, a male patient in his 30s was found pulseless with unknown down time. The patient developed post anoxic myoclonus within 1 week from cardiac arrest. Patient continued to suffer from intractable myoclonus despite being treated with brivaracetam, valproic acid, and clonazepam. Perampanel was added to his medication regimen and up-titrated to 12 mg daily over 1-2 weeks. This resulted in significant improvement in frequency and severity of myoclonus for about 6 months. Growing evidence exists for perampanel as an adjunctive treatment in patients with post hypoxic myoclonus or LAS. A review of the available literature, comprised of case reports and case series, and suggests a potential role for perampanel in patients with LAS. Further study is warranted including controlled trials of perampanel use in post hypoxic myoclonus.
Time-series analysis of evapotranspiration using normalized difference vegetation index over north-eastern and north-western agro-climatic zones of Tamil Nadu
Authors: Sabthapathy M , Ragunath KP , Pazhanivelan S , Selvakumar S , Sivamurugan AP , Kumaraperumal R , Mohammed Ahamed J , Chandrasekar K , Thiruvarassan S
Published: December 2024

Estimation of evapotranspiration spatially is mandatory for water budgeting and water resource monitoring based on crop water demand. The amount of evapotranspiration can be estimated spatially from reference evapotranspiration and fractional vegetation cover over the region. The incorporation of specific characteristics like spatial variability over the land cover produced highly reliable results. The AquaCrop model gives reference evapotranspiration based on climatic parameters like temperature, rainfall, solar radiation, relative humidity and elevation. Normalized Difference Vegetation Index (NDVI) depicts the health of vegetation spatially ranging from -1 to +1. The dimidiate pixel model converts NDVI to Fractional Vegetation Cover (FVC) which was then used as a substitute for crop coefficient value. The products of these two parameters produce actual evapotranspiration spatially over the region with high spatial resolution. The average amount of actual evapotranspiration varies for each Land Use Land Cover (LULC) type over different agroclimatic zones as the climatic parameters and water usage patterns vary for each land cover type.
Holistic competencies and AI in education: A synergistic pathway
Authors: Chan Cecilia
Published: December 2024

This editorial explores the integration of artificial intelligence (AI) and holistic competencies in education, highlighting the necessity of fostering both technical skills and human values. As AI technologies revolutionise educational methodologies, there arises an urgent need to balance technological advancements with the cultivation of holistic competencies – skills that prepare individuals not only for professional success but also for societal contributions. I reflect on my cross-disciplinary journey from engineering to education and underscore the importance of developing competencies that enhance personal and professional well-being. The paper discusses various dimensions of AI integration in education, including the ethical challenges posed by AI-giarism, AI guilt and AI literacy, and introduces the dynamic AI literacy model, which adapts AI education to specific professional needs. I also extend an invitation to all to join the global scale – Generative AI Assessment Project, aiming to collaboratively refine AI integration strategies in assessments. The editorial advocates for AI to complement, not replace, human-centric education, urging a synergistic approach to develop both AI skills and holistic competencies. By fostering AI literacy alongside traditional values, educators can ensure that students are equipped to thrive in a rapidly evolving technological landscape.
Obraz Morza Czarnego w polszczyźnie ogólnej i w polskim dyskursie parlamentarnym. Analiza korpusowa
Authors: Szczyszek Michał
Published: December 2024

In this article I present the results of corpus and lexicographic analyses of the bigram black sea. I conduct frequency, semantic, emotional and pragmalinguistic analyses of this proper name – Black Sea. I extracted these contexts from the corpora of Polish: Corpus of Parliamentary Discourse, NKJP and Monco.pl. As a result of my analysis, I obtained a linguistic picture of the Black Sea in the Polish communicative community. In parliament – in the texts of which this onim appears – the dominant negative emotion accompanying the basic theme, i.e. (current) politics, for the purpose of which, among other things, the mechanism of post-truth and post-memory are constructed using this name as elements of so-called historical politics. In general, the concept expressed by the bigram Black Sea is located on the periphery of the Polish linguistic worldview; does not constitute a prototype of “maritimeness”. The analyzed structure sends users of modern Polish to spatially, historically and mentally distant areas of Central Europe, to its southern part.
Using Inverse Distance Weighting to Determine Spatial Distributions of Airborne Chemical Elements
Authors: Fossokeng Mouafo Joseph Magloire , Tănăselia Claudiu , Nana Yakam André , Priso Jules Richard , Ketata Mohammed , Petrisor Alexandru-Ionut
Published: December 2024

Air pollution due to heavy metals has become a major problem in urban centers worldwide. Tree barks provide measurements of particulate concentration with an indication of the associated chemical composition. Assessing the air quality in a region is of paramount importance in ensuring the proper concentrations of particles in the environment, and their spatial location and distribution. Spatial modelling is a fundamental element in the tool chain for managing ambient air quality in a region. This study uses inverse distance weighting in the analysis of chemical elements from the barks of 254 trees to map heavy metals in the air of the city of Douala, Cameroon during the dry seasons (December to February, when monthly rainfall is low) of 2022. The ANCOVA model was used to compare metal concentrations in the bark with the dendrometric parameters of trees. The results may help in monitoring the spread of heavy metals in the city of Douala, in order to pinpoint the sites at risk. Our findings show that the whole city is in a state of emergency with respect to air quality, and mitigation measures must be taken rapidly throughout its territory, especially in intersections with high traffic volumes and industrial zones. We suggest planting several tall trees with large crown volumes and thick bark to reduce air pollution. Phenology and foliage appearance in trees can provide information on the type of metal-related pollution. These findings bring additional evidence that trees can act as bio-indicators and bio-accumulators in urban environments.
Complicações locais e sistêmicas em pacientes pós-angioplastia coronariana transluminal percutânea primária / Local and systemic complications in patients after primary percutaneous transluminal coronary angioplasty
Authors: Jardim Cardoso Karoline , Monteiro da Silva Debora
Published: December 2024

Objetivo: descrever as principais complicações pós-angioplastia primária em um hospital universitário. Método: pesquisa descritiva, com análise documental de registros de 78 pacientes submetidos à angioplastia primária. A coleta de dados ocorreu de setembro a novembro de 2020, em prontuários impressos, através de instrumento previamente elaborado. A análise foi por estatística descritiva. Resultados: predomínio de idosos, com média de 60,7 anos, do sexo masculino (76%), hipertensos (67,9%) e tabagistas (35,9%). As principais complicações encontradas foram hematoma (17,9%), nefropatia induzida por contraste (12,8%) e retenção urinária (5,1%). Os eventos cardíacos adversos maiores mais prevalentes foram reestenose coronariana (7,7%), óbito cardíaco (3,8%), infarto agudo do miocárdio (1,3%) e cirurgia de revascularização do miocárdio de urgência (1,3%). Conclusões: a identificação das complicações pós-angioplastia primária pode ofertar subsídios para qualificar o cuidado através da criação de protocolos de prevenção e intervenção precoce aos eventos adversos aos pacientes submetidos ao procedimento. Devido a migração para o sistema OJS3, a íntegra desse artigo pode ser acessado pelo seguinte endereço eletrônico: Complicações locais e sistêmicas em pacientes pós-angioplastia coronariana transluminal percutânea primária | Journal of Nursing and Health (ufpel.edu.br)
Rede Rizoma
Authors: De Fatima Socoowski de Anello Lucia , Regina Nobre Lucia , Angelica Machado Braga Maria
Published: December 2024

O modo de produção capitalista desumanizante, com suas ações e contradições, força os trabalhadores a enfrentá-lo construindo formas humanizantes de desenvolver a produção, a comercialização e o consumo. Tais formas se caracterizam como movimentos sociais contra hegemônicos, para enfrentar este sistema. Nosso trabalho visa entender esse processo social e contribuir para fortalecer os coletivos. Desta forma, surge a Rede Rizoma, coletivo constituído por Grupos de Consumo Responsável (GCR) e produtores de pequena escala que seguem a lógica da Economia Popular Solidária (EPS), localizados na Região Sul do Rio Grande do Sul. Este artigo busca apresentar a Rede Rizoma como uma experiência concreta e contra hegemônica. A metodologia utilizada foi revisão bibliográfica, documental e de trabalhos acadêmicos, bem como relatórios da observação participante. Os resultados encontrados são que a prática dos envolvidos na Rede Rizoma é um coletivo de coletivos que busca uma outra forma de produção, comercialização e consumo, e desta forma ir ao encontro da emancipação e da transformação dos sujeitos.
Representación social de la población indígena en los currículos de Colombia, Ecuador y Chile
Authors: Valderrama-Aguayo Iván , Angarita-Iguaran Alexandra
Published: December 2024

Introduction. One of the main tensions faced by modern educational systems is their ability to train critical citizens without losing sight of their specific cultural origins. Objective. This study analyzes how indigenous populations are socially represented in the curricula of Colombia, Chile, and Ecuador. Methodology. This study employed qualitative research to critically examined curricula of Colombia, Chile, and Ecuador. The categorical analysis focused on evaluating representation of indigenous people as social subjects and their identity. The selected analysis corpus is justified as it explicitly outlines the curricular objectives to be developed within the levels of compulsory school education and makes explicit the skills, attitudes, and levels of achievement throughout the compulsory education cycle. Results. The analysis reveals inconsistencies in the programmatic configuration, the stated pluralistic and intercultural purposes are not concretely addressed but are instead treated as thelos to reach. This situation prevents valorizing the indigenous subjects as active participants in sociohistorical dynamics. Conclusion. Transforming curricula must necessarily begin with developing acts of social and individual reflexivity regarding the objectives, indicators, and didactic strategies implemented in intercultural classrooms, as well as their alignment with the stated principles.
La identidad y formación académica de mujeres musulmanas en el País Vasco
Authors: Ghacham-Emrani Hachmioune Ikram , Pastor-Andrés David , Castrillo Janire
Published: December 2024

Objective.This research aimed to investigate the experiences of Muslim female students in higher education, with a focus on the categories of inclusion, intersectionality, identity, and interculturality. Method. Six Muslim women from different parts of the Basque Country were interviewed. Results. The results reveal that all participants possess a mixed identity, yet they have not seen their condition transferred to the classroom in terms of inclusion and interculturality. The results also suggest that these students have been affected by other forms of discrimination derived from their gender condition. Similarly, results indicate that they have been affected by the low expectations for academic success that teachers have projected on them across various educational stages, conditioning, to some extent, the construction of their academic biographies. Conclusions. These findings highlight the need to rethink how to build a more inclusive educational model in which interculturality is truly worked on.
Sistemas complejos e investigación interdisciplinaria: ejemplos de aplicación al fenómeno de la criminalidad en Ecuador y Costa Rica
Authors: Muñoz Morales R. David
Published: December 2024

Introduction. The epistemological implications of assuming Rolando García’s complex systems theory in social research are reviewed. Humanism is assumed as an affirmation that human beings are endowed with the capacity to formulate narratives about their nature, to search for an ideal of freedom and to be protagonists of their emancipation in the face of phenomena of structural violence such as that provoked by criminality in contemporary capitalism. Objective. The purpose is to reflect on how the interdisciplinary research method becomes indispensable to approach phenomena of heterogeneous elements that cannot be studied in isolation from the monodiscipline and that have the highest levels of complexity, when they are social systems. Methodology. Some examples of the application of the interdisciplinary research method to study complex systems such as the phenomenon of crime in Latin American countries experiencing recent crime booms are proposed. For this purpose, the case of crime in Ecuador and Costa Rica is chosen because they have characteristics that define them as booming systemic crises. Results. Subsystems are recognized in the scheme of criminality composed of phenomena that respond to the study of different domains of scientific knowledge but that must be approached as an organized whole in order to be understood at their respective levels of complexity. Conclusions. It is recognized that scientific progress is associated with every humanistic “outbreak” in history and that an interdisciplinary method for the study of social systems is a necessary contribution in the midst of the crises of capitalism that awaken phenomena such as modern criminality in countries once considered as an example of social cohesion.
Pagrindinio muzikinio ugdymo programos mokinių lyderystės gebėjimų raiška muzikos mokykloje: atvejo analizė
Authors: Venslavičienė Loreta , Venckienė Diana
Published: December 2024

The development of leadership skills is a continuous and ongoing process, starting in childhood. Leadership is associated with personal qualities – creativity, initiative, critical thinking, etc. This is not a natural trait, but something that has to be learnt, and education has an important role to play in the development of young leaders. Music school education focuses on subject achievements that are important for musical activity, on the development of artistic skills, and often overlooks the development of leadership skills that are important for personal maturity. Since it is assumed that the application of the transformational leadership model could enable the development of the expression of leadership skills, the article analyses the prerequisites for the expression of leadership skills in music school educational activities and the possibilities of their improvement in a particular music school in order to achieve the comprehensive success of a person’s (self-)education. The findings of the empirical research suggest that teachers in a music school focus on the development of musical abilities, while the development of leadership skills becomes a self-occurring consequence of the organisation of the process, rather than a well-thought-out and purposefully pursued goal.
Nepilnamečių baudžiamosios atsakomybės aspektai
Authors: Žiobienė Edita
Published: December 2024

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Advokatas baudžiamojoje justicijoje
Authors: Kukaitis Mindaugas
Published: December 2024

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Imagining Siberia: Cartographic Motive in the Novel of A. Ivanov Tobol
Authors: Snežko Julia
Published: December 2024

The The article considers the role of cartographic motif in the conceptualisation of space in Russian writer Alexei Ivanov’s novel Tobol. The paper reveals the connection of this motif with the main plot lines of the novel, with the structure of the novelistic space, as well as with its ideological component. The study concludes that the map functions both as a tool for traversing space (and thus conquering it), as a means of awakening poetic imagination, and as a crucial element in attempts to imagine Siberia.Drawing on the ideas of American geographer Yi-Fu Tuan, the article shows that the map in the novel is one of the most important elements in the attempt to transform space into place.
Effect of overlapping layout of Fe/TiO2 on CO2 reduction with H2 and H2O
Authors: Nishimura Akira , Tatematsu Daichi , Toyoda Ryuki , Hirota Masafumi , Koshio Akira , Fumio Kokai , Hu Eric
Published: December 2024

Fe-doped TiO2 (Fe/TiO2) film photocatalyst was prepared by sol-gel dip-coating, and pulse arc plasma process. The netlike glass fiber was used as a base material for the photocatalyst since it had a porous structure. The CO2 reduction performance with H2 and H2O into CO over the Fe/TiO2 photocatalyst was investigated. In addition, this study investigated overlapping two Fe/TiO2 coated on netlike glass fiber in order to utilize the light more effectively as well as increase the amount of photocatalyst for CO2 reduction. The characterization of prepared Fe/TiO2 film coated on netlike glass fiber was analyzed by SEM, EPMA, TEM, EDX and EELS. Furthermore, the CO2 reduction performance of the Fe/TiO2 film was tested under a Xe lamp with or without ultraviolet (UV) light, respectively. The results show that the CO2 reduction performance peaks under the condition of CO2/H2/H2O=1:1:0.5 in both cases with UV light and without UV light illumination. The highest concentration of CO with the Fe/TiO2 overlapped photocatalyst is 1.2 times of that with the single Fe/TiO2 photocatalyst. On the other hand, results also show the highest molar quantity of CO per weight of photocatalyst for Fe/TiO2 overlapped is almost half of single Fe/TiO2.
Sensory properties of dosimetric materials under conditions of parameter fluctuations: Monte Carlo method
Authors:   Institute of Electron Physics, NAS of Ukraine, 88017 Uzhhorod, Ukraine, Yavorskyi P.V. , Pop O.M. ,   Institute of Electron Physics, NAS of Ukraine, 88017 Uzhhorod, Ukraine, Maslyuk V.T. ,   Institute of Electron Physics, NAS of Ukraine, 88017 Uzhhorod, Ukraine
Published: December 2024

The results of ab initio calculations of the thermoluminescent and phospho-rescent characteristics of semiconductors used in dosimetric studies, free from any approximations, are presented. A scaling procedure is proposed to model the sensing capabilities of dosimeters of different types. This makes it possible to establish the scope of various approximations used in practical dosimetry to explain similar experimental data. For the first time, the role of statistical factors determining the range of changes in the energy and kinetic parameters of luminescent processes of actual dosimetric materials in forming their sensory characteristics was investigated. The proposed approach can com-plement the computerized glow curve deconvolution (CGCD) technique, widely used to assess the structure of energy levels and kinetic coefficients of actual dosimetric materials. The capabilities of the new method are implemented in the Lumini calculation package.
Si-based n++-p–-p+-p–-p++ avalanche diode: Self-consistent modeling for infrared optoelectronic applications
Authors:   V. Lashkaryov Institute of Semiconductor Physics, 41 Nauky Avenue, 03028 Kyiv, Ukraine, Sapon S.V. , Romaniuk B.M. ,   V. Lashkaryov Institute of Semiconductor Physics, 41 Nauky Avenue, 03028 Kyiv, Ukraine, Melnik V.P. ,   V. Lashkaryov Institute of Semiconductor Physics, 41 Nauky Avenue, 03028 Kyiv, Ukraine, Dubikovskyi O.V. ,   V. Lashkaryov Institute of Semiconductor Physics, 41 Nauky Avenue, 03028 Kyiv, Ukraine, Kulbachynskyi O.A. ,   V. Lashkaryov Institute of Semiconductor Physics, 41 Nauky Avenue, 03028 Kyiv, Ukraine, Oberemok O.S. ,   V. Lashkaryov Institute of Semiconductor Physics, 41 Nauky Avenue, 03028 Kyiv, Ukraine, Maksimenko Z.V. ,   V. Lashkaryov Institute of Semiconductor Physics, 41 Nauky Avenue, 03028 Kyiv, Ukraine, Kosulya O.V. ,   State enterprise “State research institute “Orion”, 03057 Kyiv, Ukraine
Published: December 2024

A theoretical approach for modeling electric and photoelectric characteristics of specifically designed Si-based n++-p–-p+-p–-p++ avalanche photodiodes has been developed. The electrostatic characteristics (band bending, built-in electrostatic fields and carrier distributions) and current-voltage characteristics including photocurrent and diode sensitivity to electromagnetic radiation of the near-infrared spectral range have been calculated and analyzed for the room operation temperature. The measured doping profiles in the fabricated prototype of the avalanche Si-based photodiode have been used in the calculations. For a particular set of the photodiode parameters, we have found that the avalanche transport regime occurs at the applied reverse voltage of ~ –47 V across the diode length of 380 μm We have established that the rapid exponential growth of the current densities from 0.01 to 100 μA/cm2 in the range of the applied voltages of –40 to –47 V is inherent for formation of the avalanche-type transport regime. At this, considerable photoresponsibility values of 100 to 30 A/W are predicted for electro-magnetic radiation wavelengths of 0.8 to 1 μA. All the results have been obtained using literature data on field dependences of the impact ionization coefficients, spectral dependences of the optical permittivity (refractive index and extinction coefficient), etc.
Spectral SPR effect in thin films of high-conductive metals and features of SPR-biosensors implementation in chromatic mode
Authors:   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine 41, prospect Nauky, 03028 Kyiv, Ukraine,, Kukla O.L. , Shirshov Yu.M. ,   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine 41, prospect Nauky, 03028 Kyiv, Ukraine,, Biletskiy A.I. ,   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine 41, prospect Nauky, 03028 Kyiv, Ukraine, Fedchenko O.N. ,   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine 41, prospect Nauky, 03028 Kyiv, Ukraine
Published: December 2024

In this paper, we have evaluated the application of various types of highly conductive metals for implementing the effect of spectral surface plasmon resonance (SPR) within a visible spectrum range to achieve more efficient and productive registration of biomolecules in a liquid medium using tricolor RGB cameras. Thin films of gold, silver, copper, and aluminum, as well as a bimetallic coating of silver with a gold superlayer on a glass substrate, are considered. Detailed calculations of the spectral characteristics of reflection at SPR excitation in the Kretschmann geometry are performed, particularly when a thin dielectric film is formed on the metal surface that imitates a layer of biomolecules. For each of the specified metals, the width of the region of implementation of the full-fledged SPR effect in the visible range of the spectrum is determined, and the sensitivity of the optical response to the influence of an external dielectric layer is assessed.
Multifunctional spectrophotometric sensor based on photosensitive capacito
Authors:   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine, 41 Nauky Avenue, 03028 Kyiv, Ukraine, Bacherikov Yu.Yu. ,   V. Vernadsky Institute of General and Inorganic Chemistry, NAS of Ukraine, 32/34, Academician Palladin Avenue, 03142 Kyiv, Ukraine, Okhrimenko O.B. ,   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine, 41 Nauky Avenue, 03028 Kyiv, Ukraine, Pekur D.V. ,   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine, 41 Nauky Avenue, 03028 Kyiv, Ukraine, Ponomarenko V.V. ,   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine, 41 Nauky Avenue, 03028 Kyiv, Ukraine, Sadigov A. ,   Nuclear Research Department of Innovation and Digital Development Agency, 89, Ataturk Avenue, Baku, Azerbaijan, AZ 1069, Lyubchyk S.B. ,   DeepTechLab, Lusófona University, Campo Grande, 376, 1749-024 Lisboa, Portugal, Lyubchyk S.I. ,   DeepTechLab, Lusófona University, Campo Grande, 376, 1749-024 Lisboa, Portugal
Published: December 2024

The work demonstrates the possibility of using a structure, which is similar to the structure of a powder photosensitive capacitor, as a spectrophotometric sensor. For creating an active photosensitive layer of the sensor, a suspension of ZnS:Cu:Al:Cl particles uniformly distributed in a dielectric matrix C 3 H 5 (C 18 H 33 O 3 ) 3 was used as a dielectric layer between the capacitor plates. It was shown that, depending on the characteristics of the active layer material (particle size and material, dielectric matrix properties) and the configuration of the electrical circuit, the sensor can effectively operate both in the capacitive element mode and in the voltage generator mode.
Historia y valor. Lo económico desde la crítica postoniana al marxismo tradicional
Authors: Polakiewicz Martín
Published: December 2024

En este artículo buscamos presentar la necesidad de una conceptualización más profunda de lo económico como condición de posibilidad de una crítica marxista. Para ello nos centraremos en la crítica de M. Postone al marxismo tradicional —cuyo representante en este caso es G. Markus—, para luego dar cuenta de las limitaciones de dicha crítica. Fundamentalmente, sostendremos, a partir de la argumentación, que la crítica postoniana constituye un momento exclusivamente negativo al postular la abolición del valor como objetivo de la praxis, sin construir una legalidad diferenciada de lo económico que la reemplace.
La esfera como corazón. Cardialidad medieval y erototopo en la filosofía de Peter Sloterdijk
Authors: Tillería Aqueveque Leopoldo Edgardo
Published: December 2024

Se confronta la teoría de las esferas de Peter Sloterdijk, a partir de la idea de que hay en ella un fundamento erótico que determinaría en buena medida la comprensión del cosmos esférico. La argumentación recurre a los conceptos de cardialidad esférica medieval y de erototopo para demostrar que la forma exegética, hermenéutica y a veces mitológica que adquiere el relato sloterdijkiano, orientada en principio a explicar la existencia del Homo sapiens según un fundamento ultratecnológico, podría entenderse mejor, quizás, como una impensada fenomenología del corazón.
Peregrinação
Authors: Aguiar Nobre José , Fernandes Jesuraj George
Published: December 2024

O presente texto objetiva refletir sobre o fenômeno crescente da prática do pluralismo religioso. Peregrinar aos santuários, especialmente, tornou-se um novo modo de viver a fé cristã, em busca do Sagrado. A pós-modernidade vem proporcionando este fenômeno crescente em busca da graça espiritual e do encontro com o Divino nos santuários. Estes são lugares de encontro, de sociabilidade, de fraternidade e de reconciliação que o ser humano tanto procura atualmente. A pergunta fundamental ficou assim formulada: como peregrinar de modo mais profundo e mais sábio, para se encontrar com o Sagrado em toda a parte da existência humana? Este estudo, que segue uma metodologia de pesquisa bibliográfica, ao abordar as origens da peregrinação no mundo bíblico, inspirando na peregrinação de Jesus, procura compreender como os santuários são lugares privilegiados de peregrinação hoje. Os resultados esperados estão circunscritos ao entendimento de que a teologia da peregrinação pode não somente favorecer a fé, mas também ser uma oportunidade de turismo cultural e religioso. Assim, o humano peregrina em busca da felicidade, aprende a ir ao mais distante da sua existência. Peregrinar é a arte de viver em busca do Sagrado.
Perfil dos Idosos e Longevos do Brasil Segunda edição: comparação entre 2013 e 2019 da PNS TOMO 2
Authors: José Gonçalves Bós Ângelo , Bonett Aguirre Francielle , de Paula Rocha Josemara , Maura Rubert Viviane
Published: December 2024

Foi com um misto de contentamento e aflição que aceitei o convite do Professor Dr. Ângelo José Gonçalves Bós para prefaciar a presente obra, que habilmente apresenta o perfil das pessoas idosas e longevas do Estado do Rio Grande do Sul a partir de uma análise da Pesquisa Nacional de Saúde de 2019. Do contentamento que senti, destaco o quanto é prazerosa a tarefa de apresentar uma obra tão completa e necessária, organizada por um conjunto de renomados pesquisadores da área do envelhecimento humano, da Geriatria e da Gerontologia. Da aflição que me acompanha, enquanto escrevo estas linhas sentada na minha estação de trabalho junto à Escola de Saúde Pública do Rio Grande do Sul, destaco a desacomodação que sempre me causa a análise minuciosa dos dados relativos à população idosa do nosso Estado face às tímidas políticas públicas ofertadas a este segmento populacional.
Estilo de Vida – Alimentos Naturais x Industrializados
Authors: da Rosa Camargo Liziane , Breda Martins Renata , Ceolin Jamile , Baccarin Ianiski Valéria , Braun Amanda
Published: December 2024

O envelhecimento acelerado no Brasil, com transformações sociais, industriais, epidemiológicas, nutricionais e também familiares, criou novos desafios para a sociedade e também aumento nas demandas por serviços de saúde. Quanto à questão nutricional, houve um declínio da desnutrição proteico-energética; já o excesso de peso teve um aumento em todas as faixas etárias (Guimarães; Simões; Pardi, 2019).
Doenças Transmissíveis
Authors: Clós Mahmud Ibrahim , da Rosa Lerner Erick , Bastos Giergowicz Fabíola , Viero Kowalski Carla , Cássio Pereira Grigol Marlon
Published: December 2024

Dentre as novidades da Pesquisa Nacional de Saúde (PNS) de 2019, encontra-se a inclusão do módulo temático T, que aborda doenças transmissíveis, investigação sobre presença de tosse, manchas com dormência, doença de Chagas e infecções sexualmente transmissíveis, além de aspectos relacionados à prevenção primária e secundária destas condições.
Desafios interdisciplinares em tempos de mudanças climáticas
Authors: Oliveira dos Santos Handiara , E Silva Martins Ricardo
Published: December 2024

Apresentação
Pertanggungjawaban Pidana Anak Sebagai Pelaku Pembunuhan Perspektif Hukum Pidana Islam
Authors: Fatmawati Deva
Published: December 2024

Abstract: Children are the future leaders of the country, therefore it is important to guide and protect them to improve their physical, mental, social, and emotional well-being as well as their overall growth and development. However, in the world we live in, there are many problems that arise with children ending up committing crimes such murder. The aim of this research is to find out the criminal responsibility of children who commit a crime based on the Criminal Code and Islamic Criminal Law. A normative juridical approach is used in the research process, which involves examining library sources such as special laws, papers, research findings, and so on. The results of the research show that a child who is exactly 18 years old can be subject to criminal sanctions under Article 338 of the Criminal Code and the previous perpetrator was a recidivist of the crime of theft. Meanwhile, according to Islamic Criminal Law, a child who is 18 years old must be held criminally liable because he has entered a period of mature thinking ability.
Abstrak: Anak-anak adalah pemimpin masa depan negara, oleh karena itu penting untuk membimbing dan melindungi mereka untuk meningkatkan kesejahteraan fisik, mental, sosial, dan emosional mereka serta pertumbuhan dan perkembangan mereka secara keseluruhan. Namun, di dunia yang kita tinggali ini, ada banyak masalah yang muncul dengan anak-anak yang akhirnya melakukan kejahatan seperti pembunuhan. Tujuan penelitian ini adalah untuk mengetahui bagaimana pertang­gungjawaban pidana anak yang melakukan suatu tindak pidana bersdasarkan KUHP dan Hukum Pidana Islam. Pendekatan yuridis normatif digunakan dalam proses penelitian, yang melibatkan pemeriksaan sumber-sumber perpustakaan seperti undang-undang khusus, makalah, temuan penelitian, dan sebagainya. Hasil penelitian menunjukkan bahwa seorang anak yang tepat berada di usia 18 tahun dapat dikenakan sanksi pidana pasal 338 KUHP dan pelaku sebelumnya ialah seorang residivis tindak pidana pencurian. Sedangkan menurut Hukum Pidana Islam seorang anak yang sudah berusia 18 tahun wajib dibebankan pertanggung­jawaban pidana karena telah memasuki masa kemampuan berfikir yang matang.
Is the TriNetX Database a Good Tool for Investigation of Real-World Management of Von Hippel–Lindau?
Authors: R. Hochberg Aaron , T. Gomella Patrick , Im Brian , Ghosh Anushka , Shah Sohan , A.M. Thompson Rasheed , Zarrabi Kevin K. , S. Shah Mihir , Mark J. Ryan , K. Izes Joseph , D. Lallas Costas , G. Gomella Leonard , R. Metwalli Adam
Published: December 2024

Von Hippel–Lindau (vHL) is a hereditary disease characterized by the development of benign and malignant tumors across multiple organ systems. It is seen in approximately 1 in 36,000 live births. Given that vHL is a rare disease, studies that seek to characterize vHL are often hampered by small sample sizes. The TriNetX database, which contains data from over 100 million patients, may offer the ability to define and describe a large number of vHL patients. The primary objectives of this study were to describe the prevalence of vHL-associated conditions and investigate clinical outcomes using TriNetX. The secondary objective was to compare the results of this analysis to what has been reported in the published vHL literature. TriNetX was queried to establish a cohort of patients with a diagnosis of vHL. This cohort was then used to define the prevalence of the following conditions: reproductive organ (epididymal and broad ligament) cystadenomas, renal cell carcinoma (RCC), pheochromocytomas, endolymphatic sac tumors (ESLTs), central nervous system (CNS) and retinal hemangioblastomas, and pancreatic neuroendocrine tumor (pNETs). A total of 1232 patients in TriNetX had a recorded diagnosis of vHL. Of this, 34 (6.0% of males) patients had epididymal cystadenoma, 21 (3.4% of females) had broad ligament cystadenoma, 352 (28.6%) had RCC, 251 (20.4%) had pheochromocytoma, <10 had ELST, 171 (13.9%) had CNS hemangioblastoma, 34 (2.8%) had pNETs, and 66 (5.4%) had retinal hemangioma. Compared to the existing literature, vHL and associated conditions are underdiagnosed in TriNetX, suggesting its limited use in studying this disease.
A next year after the tenth anniversary
Authors: Medvedev Dmitry
Published: December 2024

The Chimica Techno Acta (CTA) journal was launched in 2014 by a recognized expert in organic chemistry, Prof. Yuri Morzherin, as a response to the various demands of scientists specializing in chemistry, chemical engineering, and materials science. Despite the existence of numerous chemical-related journals in Russia at the time, he believed that a new journal would serve as a platform for facilitating efficient regional communication among scientists, primarily students and postdoctoral researchers from Ural and related regions. Initially published in two languages (Russian and English) and two formats (print and online), CTA has garnered attention from its readership, then transforming gradually from a purely regional edition into the well-known Russian journal.
Expression Levels of Intestinal Toll-Like Receptors 2 and 4 in Acute Inflammation Caused by Intestinal Candidiasis: An Experimental Study in Wistar Rats
Authors: Tania Putu Oky Ari , Masfufatun Masfufatun , Baktir Afaf
Published: December 2024

Background: Candida albicans grows in the gastrointestinal tract as a normal microflora that may cause intestinal candidiasis, characterized by formation of biofilm and inflammation. Candida is recognized by toll-like receptors (TLRs). This study aimed to explore the relationship between intestinal TLR 2 and TLR 4 expression levels in candidiasis at each phase of inflammation.

Methods: An experimental study was performed using a simple randomized sampling on 30 male Wistar rats divided into a control and a treatment group. Each group was inoculated with Candida albicans. Dysbiosis conditions were designed in the treatment group using multiple antibiotics and on day 5 the rats were injected with subcutaneous cortisone acetate. The groups were terminated in five different times (days 7, 14, 21, 28 and 35). On the termination day, intestinal tissue was isolated and the TLR 2 and TLR 4 expression were analyzed by immunohistochemistry. The data were analyzed by parametric test with SPSS (p<0.05) and completed by post-hoc test Least Significance Difference (LSD) to compare pairs of groups.

Results: The expression of TLR 2 and TLR 4 between control and treatment groups showed significant differences (p=0.005). In the treatment group, there was a gradual increase in the TLR2 and TLR 4 expressions. Positive expression of TLR appeared more in the submucosal or basal area than apical surface. The treatment group showed the highest expression of both TLR2 (82.37%) and TLR4 (87.40%) on termination day 35.

Conclusions: Inflammation caused by intestinal candidiasis can result in increased expression of intestinal TLR2 and 4 contributing to an increased risk of biofilm formation.
Prevalence and Resistance Patterns of Candida albicans in Diabetic and Non-Diabetic Patients with Urinary Tract Infections
Authors: Prijana Christian , Parwati Ida , Prihatni Delita
Published: December 2024

Background: Candida spp. is an opportunistic fungi genus that can turn into pathogens, especially in those with inadequate immune response such as in patients with diabetes mellitus (DM), of which Candida albicans is the most common species. This study aimed to determine the prevalence and antifungal resistance patterns of Candida albicans in DM and non-DM patients with urinary tract infections (UTIs).

Methods: A retrospective descriptive observational study was conducted in 2023 using medical record data of DM and non-DM patients with UTIs who were treated at a tertiary hospital in Bandung, Indonesia from July 2019 to December 2021. Data on patient characteristics, proportion of fungal species causing UTI, and antifungal resistance patterns of Candida albicans were analyzed using Microsoft Excel 2019 and presented in tabular form and chart.

Results: Of a total 291 patient data, 21 were DM patients and 270 were non-DM patients, mostly were female, 71.4% and 58.2%, respectively. The prevalence of Candida albicans in DM patients was 66.7% and in non-DM patients was 70.7%, mostly resistant to micafungin (7.1% and 8.9%, respectively).

Conclusion: Female is more susceptible to UTIs. More than half of DM and non-DM patients with UTIs are infected with Candida albicans, and mostly resistant to micafungin. Antifungal treatment guidelines based on resistance patterns and education on personal hygiene to prevent UTIs are recommended.