bluuebunny/crossref_metadata_2025 huggingface dataset:
Antioxidant Activity Methods
Authors: Faraone Immacolata , Russo Daniela , Labanca Fabiana , Lela Ludovica , Ponticelli Maria , Sinisgalli Chiara , Milella Luigi
Published: June 2023

Antioxidants are groups of substances able to prevent and delay the
oxidation of easily oxidizable molecules and avoid free radicals’ formation. In living
organisms, the main free radicals are reactive oxygen species and reactive nitrogen
species. At low levels, they are involved in the regulation of diverse physiological
processes, but an imbalance between free radicals and the ability of the body to
eliminate them results in a pathological condition called oxidative/nitrosative stress.
Oxidative/nitrosative stress causes damage to cellular structures such as lipids, nucleic
acid, and proteins, compromising cellular health and viability and inducing the
development of several diseases. Physiological systems are able to contrast the free
radical excess, through the endogenous enzymatic materials (e.g., uric acid, glutathione
etc.), and via transcription factor activation. The uptake of natural antioxidants can
contribute to prevent cellular damage and exert beneficial effects. Natural antioxidants
are generally derived from plant sources and they play an important role by directly
scavenging free radicals or increasing antioxidant defences. Natural antioxidants have
gained remarkable interest and several methods have been developed for identifying
their antioxidant capacity. This chapter reviews the major in vitro and in vivo assay
procedures for the antioxidant activity estimation describing materials, extract types,
extracts/pure compounds' concentrations, step by step processes and calculations for
each assay. Advantages and limitations, as well as the molecular mechanisms of each
method have been reported.
Activity Methods for Polycystic Ovary Syndrome
Authors: Ayse Demirel Murside , Taban Akça Kevser , Çetinkaya Sümeyra , Süntar Ipek
Published: June 2023

Polycystic ovary syndrome (PCOS) is one of the most common gynecological disorders among women of reproductive age. The secretion rate and metabolism of estrogens and androgens are disrupted in patients with PCOS. Patients have systemic inflammation, hyperinsulinemia, hyperandrogenism, and polycystic ovaries. Several experimental models have been developed and studied for the investigation of this disease. These studies aim to explore the pathophysiology of PCOS and new treatment approaches. Some plant extracts and phytochemicals obtained from them are shown to be effective against PCOS in literature. In this chapter, general information about PCOS, plant-based treatment approaches, and activity methods are explained in detail.
Activity Methods For Animal Pharmacokinetic and Pharmacodynamic Studies
Authors: Montanaro Rosangela , Maione Francesco , Brancaleone Vincenzo
Published: June 2023

This chapter provides an overview of the main features that need to be
assessed with respect to the general pharmacology (pharmacokinetics, PK;
pharmacodynamics, PD) of all molecules, including natural compounds. Here, the
attention has been focused on bioavailability, the volume of distribution, and clearance
to describe the physiological processes of absorption/distribution and elimination of
drugs from the body. It is worth pointing out that PD studies always require an in vitro
preliminary approach, not issued here, that needs to be assessed and confirmed in vivo.
Indeed, PD studies aim to the individuation of specific molecular targets, responsible
for an observed pharmacological effect. Thus, the use of animal models as a complex
approach does not allow to dissect the molecular mechanisms of natural compounds
but can confirm their efficacy in vivo. Therefore, specific PD approaches to determine a
specific action by a compound are addressed in the relevant chapters within this book.
Seasonal and spatial characteristics of suspended sediment load and their controlling factors in the Upper Indus River Basin, Pakistan
Authors:   Key  Laboratory of Tibetan Environment Changes and Land Surface Processes, Institute of Tibetan Plateau  Research, Chinese Academy of Sciences, Beijing, China, Jagirani Muhammad Dodo , Shi Xiaonan , Zhang Fan , Khalighi - Sigaroodi Shahram , Zeng Chen , Xiao Xiong , Wang Li , Qaiser Faizan ur Rehman , Wang Guanxing
Published: June 2023

Understanding the seasonal and spatial characteristics of suspended sediment load is extremely important for efficient water resource management. The characteristics of suspended sediment load reflect the soil erosion, transport, and deposition. The upper Indus basin is a single source of fresh water and hydropower generation for the surroundings and downstream areas with a population of millions approximately. Simultaneously, the water resources in this area are badly affected by the sedimentation. Therefore, the focus of this study is to evaluate the seasonal variation and spatial distribution of suspended sediment load and figure out their controlling factors by using hydrometeorological data series collected from WAPDA and PMD. Annual sediment load at four mainstream stations accounted for 34.0 at Kachura, 86.7 at Bunji Bridge, 75.7 at Shatial and 57.7 (Mt) at Besham, respectively. The high sediment loads were observed during the summer season, accounting for 77.4% at Kachura, 85.6% at Bunji Bridge, 73.7% at Shatialand 76% at Beshamand 92.9% at Shyok, 69.1% at Hunza, 47.9% at Gilgit and 57.0% at Astore tributary respectively. Conclusively, contrasting suspended sediment load variability was observed throughout the study area. The high values of sediment loads were observed during the summer season, especially occurred during June, July and August. This indicates that serious soil erosion occurred during these three months in the area. It is therefore, strongly recommended to reduce soil loss and launch soil conservating activities, forestation and professional development work in the area, which could play an effective role to extend the lifeline of proposed water resource projects, especially the Diamer Bhasha (an under-construction dam in the region).
Coffee Husk and Coffee Ground as an Adsorbent for the Removal of Lead, Copper and Chromium from Aqueous Solution
Authors:   Department of Chemistry, College of Natural & Computational Sciences,  Wolaita Sodo, Ethiopia, Yifira Medhanit Tefera , Doda Mesfin Bibiso , Kanido Camerun Kastro
Published: June 2023

This study aimed to investigate the removal efficiency of coffee husk and coffee ground adsorbents to adsorb lead(II), copper(II), and chromium(VI) from an aqueous solution. Standard lead nitrate, potassium dichromate, and copper chloride solutions were prepared following standard laboratory procedures. The residual metallic ion concentrations were determined using Atomic Absorption Spectrometer (AAS). The experimental parameters such as pH, contact time, adsorbent dosage, agitation speed and initial concentration of selected metal ions were evaluated at different particle size fractions (>200 µm and 200 µm, the removal efficiency of coffee husk and coffee ground investigated were 93.2% and 96.06%, 97.2% and 83%, and 92.4% and 94.46% for lead(II), copper(II) and chromium(VI), respectively. The obtained results show that coffee husk and coffee ground adsorbents used in this study can serve as excellent bio-sorbent for efficiently removing selected heavy metals from the aqueous solutions.
ANORECTAL MALFORMATION WITH VAGINAL AGENESIS: A CASE REPORT
Authors: Nabilla Hardiyanti Ginanda , Normahayu Indrastuti , Pradana Eggy Jita , Widanto
Published: June 2023

Vaginal agenesis is characterised by primary amenorrhea in adolescent women and other abnormalities, such as the absence of the uterus. The incidence of vaginal agenesis or distal vaginal atresia associated with anorectal malformations is difficult to estimate. A 5-year-old patient, at birth, immediately cried, and faeces came out through an orifice in the skin under the vagina. Previously, the patient had planned for a posterior sagittal anorectoplasty (PSARP), but it was known that the patient did not have a vaginal opening at the time of surgery. The patient was diagnosed with a low-type anorectal malformation, vaginal agenesis, and a sigmoidostomy status. PSARP and vaginoplasty were performed while the patient was 7 years old. Clinical and radiographic examination in the first 3 days of age plays a role in determining the type of anorectal malformation and whether or not a colostomy is necessary. In children, MRI radiology plays a role in the preoperative examination to evaluate the size, morphology, and stage of development of the muscular sphincter.
Keywords: anorectal malformations, vaginal agenesis.
THE EVOLUTION OF RADIOLOGICAL IMAGES IN A 4-MONTH-OLD INFANT WITH CONGENITAL PULMONARY AIRWAY MALFORMATION: A CASE REPORT
Authors: Sigiro Rahel Margareth Febriana , Dini Rachma Erawati
Published: June 2023

Congenital pulmonary airway malformation, formerly known as congenital cystic adenomatoid malformation, is a heterogeneous group of cystic and non-cystic pulmonary lesions marked with the overgrowth of primary bronchioles, which is associated with an abnormal bronchial tree that does not have cartilage. A 4-month-old boy came with a complaint of productive coughs since he was 3 weeks old, fever since the age of 2 months, and shortness of breath. The patient was once hospitalized due to pneumonia and suspected tuberculosis. After undergoing serial chest radiographs, the results showed multiple cysts that were dominant in the lower lobe of both lungs with surrounding infiltrates. Through the confirmation of a chest CT scan, there were small, multiple cysts with a size of <2 cm in both lungs, connected to the bronchial branch, accompanied by consolidation with an air bronchogram suggestive of type 2 congenital pulmonary airway malformation. Congenital pulmonary airway malformation is a rare case that usually requires serial chest radiographs to assist in the establishment of its diagnosis and a CT scan for a definitive diagnosis of its lesions.
Keywords: CPAM, congenital, pulmonary malformation, imaging
Addressing Portal Hypertension: Exploring the Crucial Role of Partial Splenic Embolization in Critical Situations
Authors: Suwanto Agnes Wanda , Amalia Fini , NA Achmad Bayhaqi
Published: June 2023

Background: Esophageal varices are one of the most common symptoms of direct outcomes of portal hypertension besides ascites, hepatorenal syndrome, and hypersplenism. Nonselective beta-blockers or band ligation are currently the effective primary preventive options for variceal hemorrhage. The use of partial splenic arterial embolization for the management of variceal hemorrhage in patients with portal hypertension has been described in a small number of reports.
Case Report: A girl, 6 y.o., was hospitalized with hematemesis with hypovolemic shock. Laboratory findings show anemia and thrombocytopenia. Radiology and endoscopy show grade III esophageal varices with hepatosplenomegaly. Because of the high risk of morbidity in surgical procedures, partial splenic embolization was performed to treat portal hypertension.
Discussion: The combination of varices and a low platelet count puts these patients at high risk for catastrophic hemorrhage. Partial splenic embolization reduces splenic blood volume, resulting in a decrease in venous drainage and a reduction in portal venous flow and pressure.
Conclusion: The use of partial splenic arterial embolization to manage variceal hemorrhage in patients with portal hypertension has been described. Embolization can be used alone or in combination with other therapies, like endoscopic ligation or retrograde transvenous variceal obliteration, to treat a variety of conditions.
Keywords: Embolization, esophageal varices, splenomegaly, portal hypertension
PENGEMBANGAN METODE PERBANYAKAN Crocidolomia pavonana F. (LEPIDOPTERA: PYRALIDAE) DENGAN PAKAN BUATAN BERBAHAN DASAR KECAMBAH KACANG HIJAU
Authors: Pangestika Widya , Himawan Toto , Widjayanti Tita
Published: June 2023

Pakan buatan yaitu pakan yang sengaja dibuat oleh manusia untuk pemeliharaan serangga dalam siklus hidupnya. Penelitian ini bertujuan untuk membandingkan metode perbanyakan C. pavonana dengan pakan buatan yang dimodifikasi dengan kecambah kacang hijau dan dibandingkan dengan pakan alami daun kubis. Penelitian ini dilakukan pada bulan Juli - November 2019. Setiap perlakuan, pakan alami (P0) dan pakan buatan (P1), dilakukan 3 kali pengulangan, setiap pengulangan terdiri dari 20 wadah dengan masing-masing wadah berisi 1 larva, sehingga terdapat 120 wadah rearing larva. Hasil penelitian menunjukkan bahwa persentase telur yang menetas antar dua perlakuan sama yaitu 64,63% per imago pada pakan alami dan 62,28% per imago pada pakan buatan. Rerata total fase pada fase larva pada pakan alami lebih cepat yaitu 11,64 hari dan pakan buatan 15,48 hari. Fase pembentukan pra pupa menjadi pupa pada pakan alami (1,6 hari) menunjukkan hasil yang lebih cepat daripada pakan buatan (2,37 hari). Lama stadium pupa pada pakan alami 6,08 hari sama dengan pupa pada pakan buatan 7,03 hari. Hasil data abnormalitas menunjukkan 13,33% pupa gagal menjadi imago pada pakan buatan. Lama hidup imago pada pakan buatan lebih cepat (9,85 hari) dibanding pakan alami (10,16 hari).
Taylan Acar ve Şemsa Özar' ın Emek, Beden, Aile Türkiye' de Kadınlık Hâlleri Adlı Eserinin Değerlendirilmesi / Review of Emek, Beden, Aile Türkiye’de Kadınlık Hâlleri (Ed.) by Taylan Acar & Şemsa ÖzaE
Authors: Sezgin Sezanur
Published: June 2023

Taylan Acar ve Şemsa Özar’ın Emek, Beden, Aile Türkiye’de Kadınlık Hâlleri Adlı Eserinin Değerlendirilmesi
Pengaruh Kualitas Pelayanan Terhadap Kepuasan Peserta Didik pada LKP Bahasa Inggris di Kota Malang
Authors: Rahmania Nur Cholidia , Redjeki Endang Sri , Widianto Edi
Published: June 2023

Abstrak: Kualitas pelayanan menjadi salah satu tolak ukur dalam menilai kualitas LKP, sedangkan kepuasan merupakan aspek luaran dalam menilai kualitas pelayanan LKP. Meningkatnya jumlah LKP di Kota Malang menjadi hal yang menarik, apakah dengan banyaknya LKP di Kota Malang selaras dengan kualitas pelayanan yang diberikan?. Penelitian ini bertujuan untuk: 1) mengetahui kualitas pelayanan LKP Bahasa Inggris di Kota Malang, 2) mengetahui kepuasan peserta didik pada LKP Bahasa Inggris di Kota Malang, 3) menganalisis pengaruh kualitas pelayanan terhadap kepuasan peserta didik pada LKP Bahasa Inggris di Kota Malang. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian survey. Analisis data penelitian menggunakan statistik deskriptif dan explanatory research. Hasil penelitian menunjukkan bahwa: 1) kualitas pelayanan pada LKP Bahasa Inggris di Kota Malang dikategorikan baik, 2) kepuasan peserta didik atas layanan yang diberikan LKP Bahasa Inggris di Kota Malang dikategorikan puas, 3) terdapat pengaruh kualitas pelayanan terhadap kepuasan peserta didik pada LKP Bahasa Inggris di Kota Malang. The Effect of Service Quality on Student Satisfaction at the English Course and Training Institute (LKP) in Malang.Abstract: Service quality is one of the benchmarks in assessing the quality of LKP, while satisfaction is an output aspect in evaluating the quality of LKP services. The increasing of LKP in Malang is an interesting matter. Is the number of LKP in Malang consistent with the quality of services provided? This study aims to: 1) knowing the service quality of English LKP in Malang, 2) knowing student satisfaction in English LKP in Malang, 3) analyze the effect of service quality on student satisfaction in English LKP in Malang. This research uses a quantitative approach to the type of survey research. Data analysis used descriptive statistics and explanatory research. The results showed that: 1) the quality of service at the English LKP in Malang was categorized as good, 2) the students' satisfaction with the services provided by the English LKP in Malang was categorized as satisfied, 3) there was an effect of the effect of service quality on student satisfaction at the LKP English in Malang.
The Role of Giri Mulya Study Group Community in Improving Community Empowerment
Authors: Yusuf Ali , Susilo Heryanto , Mardliyah Sjafiatul , Nugroho Rivo
Published: June 2023

This study examinedcommunity needs for community empowerment oriented to regional potential. The empowerment was conducted by Giri Mulya Study Group Community using the community-based community resource management process. This community is a form of a development strategy and community empowerment that contributes to controlling and managing productive resources. This research employed thequalitative research method, while the approach used in this research was the case study approach. The research informants were selected using the snowball sampling technique, and data were collected through observation and in-depth interviews. Giri Mulya Study Group Community development had a positive impact on community empowerment in Munggugebang village. Cooperation that existedamongelements of society can be a significant impetus to carry out an empowerment process. Sustainability of education in the Giri Mulya Study Group Community is the most basic effort in empowering an area, in this case, rural areas.
The Development of Teaching Materials Based Outcome-Based Education Curriculum to Encourage Teacher Skill
Authors: Wibowo Setiawan Edi , Sujarwo Sujarwo
Published: June 2023

This study seeks to describe the development of teaching materials in the Elementary Indonesian Language and Literature Learning Development Course in the Elementary School Teacher Education Study Program, Yogyakarta State University. This research is included in qualitative research. The setting of this research is in the Elementary School Teacher Education Study Program, Yogyakarta State University on 27 September 2021 to 27 September 2021. The data of this research are in the form of issues that arise in the Elementary School Teacher Education Study Program, Faculty of Education, Yogyakarta State University. Sources of data in this study were students, lecturers, and stakeholders of the Faculty of Education, State University of Yogyakarta. Data collection techniques using interviews and documentation. Data analysis techniques in this study used qualitative data analysis techniques. The result of this research is the idea to solve this problem is to develop syllabi and teaching materials for the Indonesian Language and Literature Learning Development Course, which is oriented towards the OBE curriculum. In the implementation of this stuttering, there is a change in the arrangement of stages, namely prioritizing stage IV, namely compiling teaching materials for the SD Indonesian Language and Literature Learning Development Course concerning the OBE Curriculum.
Ceramic Raku Practice through the Context of Islamic Art Practice in Malaysia
Authors: Mohd Aris Khairul Nizan , Vermol Verly Veto , Abdul Rahin Zuraidy , Muhammad Fuad Intan Nor Firdaus
Published: June 2023

In contemporary Malaysian art, the concept of authenticity has faced a dilemma, which emerges from ambivalence in the Malay/Muslim community in their belief towards the issues of representation in Islamic art practice. This research will attempt to answer the questions raised in addressing the dilemma of ceramic Raku; a traditional Japanese Ceramic firing practice through the context of Islamic art practice in Malaysia observed as contemporary Malaysia art.
Designing Ceramic Tureen Surface Pattern through the Influence of Malaysian Batik
Authors: Noordin Siti Noor Azila , Abdul Rahim Syaza , Vermol Verly Veto , Abd Rahim Zuraidy , Mohamed Raif Diana
Published: June 2023

Ceramic Tureen refers to the ‘serving ware' that are widely used in Malaysian community. On the other hand, the surface decoration increases aesthetic value of the ‘serving ware' especially in promoting the local contexts and meaning. However, this local context design in regard to tureen surface design is being over shadowed by European style and identity design pattern. This study is to associate the tureen with local context design of batik character by introducing batik as an idea to pattern design. Batik pattern design will be applied on the ceramic tureen ‘serving ware'.
Geometrical Motifs Batik Sarongs Kelantan and Terengganu
Authors: Legino Rafeah , Zuhir Nikfarhana , Samin Mohd Azhar
Published: June 2023

This study shows how geometric patterns are used on some Kelantan and Terengganu batik sarongs. A visual research visit was made to batik makers in Kelantan and Terengganu. This study was unique because it was based on observation and had the right digital documentation for further analysis.  Geometric features were mapped using recent and previous related literature and visual images. This method will help figure out how long motifs last and how they change in both states. The results showed the motifs, how the basic geometric shapes were made, and how other characters showed up in the geometric settings.
LANDSLIDE SUSCEPTIBILITY INDEX AND NETWORK MAPPING FOR SPOTTING THE AFFECTED AND ALTERNATIVE PLANNING ROUTES
Authors: Abdul Rasam Abdul Rauf , Mardie Dorisin , Mohd Said Mohd Shahmy , Hashim Nurhanisah , Ghazali Rosmadi
Published: June 2023

Millions of people were harmed by landslides, and many have lost their lives. Instead of widening the access road during a landslide, an alternative or new road should be introduced accurately. This study was conducted to determine an appropriate GIS-based alternative planning route during landslides in Ranau, Sabah, Malaysia. For determining the criteria weights of the landslide, a GIS-based Multi-Criteria Decision Making (GIS-MCDM) technique was utilised with the extension of the Analytical Hierarchy Process (AHP). The Landslide Susceptibility Index (LSI) map was created using lithology, slope, aspect, rainfall, land use or land cover (LULC), and proximity to a stream. The map was compared with the NASA-landslide historical data for the verification. The study found that lithology, slope, and aspect were the most contributing factors to the local landslide occurrences. The route from Pinausuk to the destination position of Kundasang is the most appropriate choice. An alternative planning route map is a helpful tool for the authorities and it might be also made available to the public, so they will know which path can be taken for more secure alternative access during landslides.
WHAT MOTIVATES THE MALAYSIAN HOMEBUYERS TO GO GREEN?
Authors: Chuweni Nor Nazihah , Mohamed Saraf Mohamad Haizam , Fauzi Nurul Sahida , Md Wadzir Mohammad Fitry
Published: June 2023

There are various factors influencing purchase intention to invest in commercial green buildings, however, less discussion found on motivations to invest in green residential properties. The rigorous and extensive literature review identified three main motivations for a green residential property investment, namely, environment, social, and economic concerns. The data was collected by distributing questionnaires through survey methods to the green residential owners or residents in Penang and Selangor, Malaysia. The relative importance index is adopted to analyse the data from a sample of 171 respondents through a judgemental sampling. Based on the result, the researcher found that environmental concerns were ranked as the main motivating factor influencing green homebuyers' decisions. This was followed by the social and economic benefits of minimising cost and maximising financial return. The result could lead to a greater demand for future sustainable development of residential properties, and future investment.
The principle of organizing an underwater radio communication channel using spherical antennas
Authors: Tomilin A. K.
Published: June 2023

The principle of operation of spherical antennas, which were used in experiments on the transmission of a short-wave radio signal in the marine environment, is theoretically described. A solution of a spherically symmetric electrodynamic problem based on the experimentally found potential component of the magnetic field is proposed. The characteristics of a potential wave process in an electrically conductive medium are determined. The law of transformation of an electromagnetic wave at the "conductor-dielectric" interface has been established. Keywords: generalized electrodynamics, longitudinal electromagnetic waves, potential magnetic field.
Information encoding using two-level generation in a quantum dot laser
Authors: Maximov M. V.  , Shernyakov Yu. M.  , Gordeev N. Yu.  , Nadtochiy A. M.  , Zhukov A. E.
Published: June 2023

We propose an approach for encoding and transmitting information based on the use of a quantum dot laser, which, depending on the injection current, emits either one of two or simultaneously two spectral components, with different wavelengths. When the laser is modulated by current, each lasing line is detected by an independent photodiode, and thus the information is encoded by both the intensity of each line and its wavelength. Keywords: quantum dot lasers, two-state lasing, multilevel signaling, wavelength- division multiplexing.
Predicción del fracaso empresarial utilizando métricas de flujo de efectivo
Authors: Lambreton Torres Viviana
Published: June 2023

El propósito de esta investigación es examinar la eficiencia de métricas de flujo de efectivo para pronosticar la probabilidad de quiebra de las compañías. A través de un modelo de regresión logística, se analizó la información de 58 empresas con problemas financieros graves y 54 empresas sanas por un período de 5 años. Los resultados indican que cinco de las diez métricas analizadas son predictores eficientes de la probabilidad de quiebra, con un porcentaje de predicción correcta del 87.73% de los casos. De igual forma, se determinó que las empresas sanas y con dificultades financieras presentan métricas de flujo estadísticamente diferentes entre sí, por lo que se recomienda un mayor uso de índices de flujo de efectivo en el análisis financiero. La limitante de este estudio fue el conformar la muestra de empresas que se hayan declarado formalmente en quiebra al 31 de diciembre del 2019. Esta investigación aporta al conocimiento al demostrar que las métricas de flujo de efectivo son una herramienta confiable en el pronóstico de la probabilidad de problemas financieros graves en el contexto de México.
Improving Surveillance of Human Tick-Borne Disease Risks: Spatial Analysis Using Multimodal Databases
Authors: Maxwell Sarah P , Brooks Chris , Kim Dohyeong , McNeely Connie L , Cho Seonga , Thomas Kevin C
Published: June 2023

Background

The extent of tick-borne disease (TBD) risk in the United States is generally unknown. Active surveillance using entomological measures, such as presence and density of infected nymphal Ixodes scapularis ticks, have served as indicators for assessing human risk, but results have been inconsistent and passive surveillance via public health systems suggests TBDs are underreported.

Objective

Research using various data sources and collection methods (eg, Google Trends, apps, and tick bite encounters [TBEs] reports) has shown promise for assessing human TBD risk. In that vein, and engaging a One Health perspective, this study used multimodal databases, geographically overlaying patient survey data on TBEs and concomitant reports of TBDs with data drawn from other sources, such as canine serological reports, to glean insights and to determine and assess the use of various indicators as proxies for human TBD risk.

Methods

This study used a mixed methods research strategy, relying on triangulation techniques and drawing on multiple data sources to provide insights into various aspects of human disease risk from TBEs and TBDs in the United States. A web-based survey was conducted over a 15-month period beginning in December 2020 to collect data on TBEs. To maximize the value of the covariate data, related analyses included TBE reports that occurred in the United States between January 1, 2000, and March 31, 2021. TBEs among patients diagnosed with Lyme disease were analyzed at the county level and compared to I scapularis and I pacificus tick presence, human cases identified by the Centers for Disease Control and Prevention (CDC), and canine serological data. Spatial analyses employed multilayer thematic mapping and other techniques.

Results

After cleaning, survey results showed a total of 249 (75.7%) TBEs spread across 148 respondents (61.9% of all respondents, 81.7% of TBE-positive respondents); 144 (4.7%) counties in 30 states (60%) remained eligible for analysis, with an average of 1.68 (SD 1.00) and median of 1 (IQR 1) TBEs per respondent. Analysis revealed significant spatial matching at the county level among patient survey reports of TBEs and disease risk indicators from the CDC and other official sources. Thematic mapping results included one-for-one county-level matching of reported TBEs with at least 1 designated source of human disease risk (ie, positive canine serological tests, CDC-reported Lyme disease, or known tick presence).

Conclusions

Use of triangulation methods to integrate patient data on TBE recall with established canine serological reports, tick presence, and official human TBD information offers more granular, county-level information regarding TBD risk to inform clinicians and public health officials. Such data may supplement public health sources to offer improved surveillance and provide bases for developing robust proxies for TBD risk among humans.
TELEMED: Database on Evidence-Based Telemedicine in a Hospital Setting (Preprint)
Authors: Wagner Svendsen Ida , Kidholm Kristian
Published: June 2023

BACKGROUND

The use of telemedicine services has increased worldwide during recent years as a result of national strategies for the digitalization of health care and the COVID-19 pandemic. However, health care professionals often express uncertainty regarding the evidence and effectiveness of telemedicine interventions. Therefore, the Centre for Innovative Medical Technology at Odense University Hospital introduced the TELEMED database, an evidence-based telemedicine database.

OBJECTIVE

This study aimed to ensure that hospital managers, health care professionals, and other stakeholders gain access to information about scientific studies of telemedicine interventions and their effectiveness.

METHODS

The database constitutes a structured literature search in PubMed for randomized controlled trials or controlled trials on the effect of telemedicine for somatic diseases treated at hospitals. The search was conducted by staff members in the Health Technology Assessment unit at the Centre for Innovative Medical Technology. First, identified studies were sorted by screening titles and abstracts and, subsequently, by reading full-text versions. The data extracted from the studies included the setting, intervention, patient group, type of telemedicine, clinical effect, patient perception, and implementation challenges. Finally, the value of each study was assessed with respect to effectiveness.

RESULTS

A total of 518 articles were included for data extraction and assessment. The database provides results from 22 different specialties and can be searched using the following criteria: medical specialty, country, technology, clinical effect, patient experience, and economic effect. The database serves as a platform for the dialogue with clinical departments who wish to implement telemedicine services and has a large potential for supporting the digital transformation during COVID-19 as evidence-based information on patient groups, relevant technologies, and their effect is easily accessible.

CONCLUSIONS

The TELEMED database provides an easily accessible overview of existing evidence-based telemedicine services. The database is freely available and is expected to be continuously improved and broadened over time.
The Association Between Family Health and Frailty With the Mediation Role of Health Literacy and Health Behavior Among Older Adults in China: Nationwide Cross-Sectional Study (Preprint)
Authors: Li Haomiao , Wu Yibo , Bai Zhongliang , Xu Xiwu , Su Dai , Chen Jiangyun , He Ruibo , Sun Ju
Published: June 2023

BACKGROUND

Family health develops from the intersection of the health of each family member and their interactions and capacities as well as the family’s internal and external resources. Frailty is the most prominent and typical clinical manifestation during population aging. Family health may be effective in addressing frailty, and this association may be mediated by health literacy and health behaviors. Until now, it is unclear whether and how family health affects frailty in older adults.

OBJECTIVE

This study aimed to examine the associations between family health and frailty and the mediation roles of health literacy and health behaviors.

METHODS

A total of 3758 participants aged ≥60 years were recruited from a national survey conducted in 2022 in China for this cross-sectional study. Family health was measured using the Short Form of the Family Health Scale. Frailty was measured using the Fatigue, Resistance, Ambulation, Illnesses, and Loss of weight (FRAIL) scale. Potential mediators included health literacy and health behaviors (not smoking, not having alcohol intake, physical exercise for ≥150 minutes per week, longer sleep duration, and having breakfast every day). Ordered logistic regression was applied to explore the association between family health and frailty status. Mediation analysis based on Sobel tests was used to analyze the indirect effects mediated by health literacy and behaviors, and the Karlson-Holm-Breen method was used to composite the indirect effects.

RESULTS

Ordered logistic regression showed that family health is negatively associated with frailty (odds ratio 0.94, 95% CI 0.93-0.96) with covariates and potential mediators controlled. This association was mediated by health literacy (8.04%), not smoking (1.96%), longer sleep duration (5.74%), and having breakfast every day (10.98%) through the Karlson-Holm-Breen composition.

CONCLUSIONS

Family health can be an important intervention target that appears to be negatively linked to frailty in Chinese older adults. Improving family health can be effective in promoting healthier lifestyles; improving health literacy; and delaying, managing, and reversing frailty.
Exploring the Effects of Incorporating Egg Powder Containing Phospholipase α2 Antibody on Ground Striploin Shelf-Life
Authors: Velasco Ayala Carolina , Koulicoff Larissa A. , Chun Colin K. Y. , Boyle Elizabeth A. E. , O'Quinn Travis G. , Richards Mark P. , Jones Cassandra , Chao Michael D.
Published: June 2023

Lipid oxidation in beef may be enhanced by the hydrolysis of phospholipids by phospholipaseα2 (PLA2) during postmortem storage. Anti-phospholipaseα2 (aPLA2) is an antibody that can inhibit PLA2 activity. Past research has shown that aPLA2 can be mass-produced in the form of egg powder (EP) from hens immunized against PLA2. Therefore, the present study aimed to determine the effects of incorporating different levels of EP containing aPLA2 into ground striploin (GS) to assess its ability to extend beef shelf-life. Ten striploins were collected from 10 USDA Choice beef carcasses. Each striploin was ground and equally divided into 4 batches, and each batch was mixed with 0%, 0.4%, 0.8%, or 1.6% dried EP containing aPLA2. Each treatment batch was further divided into 3 smaller batches and subjected to retail display (0, 4, or 7d). Color descriptors, pH, proximate analysis, lipid oxidation, antioxidant capacity, and phospholipid and fatty acid (FA) profiles were measured. Percent visual discoloration and instrumental color measurements of GS were unaffected by aPLA2 EP treatments (P>0.05). The 1.6% treatment GS had a higher relative percentage of phosphatidylcholine compared with those from the 0% treatment (P<0.05), but the lack of lysophosphatidylcholine generation in the GS from any treatment reflects a lack of detectable level of PLA2 activity. Moreover, the addition of EP in GS increased the relative percentage of FA 11-18:1, 18:2, 20:1, and 22:6 (P<0.05). As a result, there was more lipid oxidation for GS from the 1.6% treatment compared with those from the 0% treatment (P<0.05), but GS from the 0.8% treatment showed higher antioxidant activity than those from the 0% treatment (P<0.05). In this study, the addition of EP containing aPLA2 did not demonstrate any effect to extend shelf-life when incorporated into GS.
Morbilidad y mortalidad del cáncer infantil en un departamento del sur de Colombia
Authors: González-Casagua María Sofía , Bermeo-Calderón Juan David , Montalvo-Arce Carlos Andrés , Laverde Gaona Luis Alfonso , Tafurt-Cardona Yaliana
Published: June 2023

Introducción: El cáncer infantil tiene repercusiones en la calidad de vida a corto y largo plazo de los niños afectados. En Colombia representa la tercera causa de muerte entre 1 y 14 años de edad. Objetivo: Describir la morbimortalidad por cáncer infantil en el departamento del Huila durante el periodo 2012 – 2016. Materiales y métodos: Se realizó un estudio descriptivo de tipo exploratorio en menores de 18 años con diagnóstico de cáncer durante el 2012 a 2016 en el Huila, a partir de la información obtenida del Sistema Integral de Información de la Protección Social y Departamento Administrativo Nacional de Estadística de Colombia. Resultados: Se detectaron 568 casos de cáncer infantil durante el periodo de estudio. El 54,3% correspondía a pediátricos del sexo masculino, 39,8% con edades comprendidas entre 10 a 14 años de edad, 60,4% residentes de la zona norte del departamento. Se registraron 117 casos de mortalidad por cáncer, con mayor frecuencia entre 5-9 años de edad, del sexo masculino. Conclusiones: Se evidenció altas tasas de morbimortalidad por cáncer infantil en la zona norte del departamento, se resalta la necesidad de futuras investigaciones que puedan explicar el comportamiento de tumores infantiles y definir programas de intervención
Pengaruh Level Protein Kasar terhadap Perubahan Dimensi Tubuh Sapi Donggala Induk Muda
Authors: Gazali Syafatur Rahman Al , Marsetyo Marsetyo , Nirwana Nirwana , Zainal Zainal , Mustafa Mustafa
Published: June 2023

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian pakan dengan level protein kasar (PK) terhadap perubahan dimensi tubuh sapi donggala induk muda. Penelitian ini dilaksanakan selama 10 minggu yaitu pada pada bulan Oktober-Desember 2020, bertempat di kandang penelitian bertempat di Desa Potoya, Kecamatan Dolo kabupaten Sigi, Sulawesi Tengah. Ternak yang digunakan dalam penelitian ini adalah sapi Donggala induk muda yang berjumlah 20 ekor dengan umur sekitar 2,5 - 3 tahun dan kisaran bobot badan antara 250 - 350 kg. Penelitian ini didesain dengan menggunakan. Rancangan Acak Kelompok (RAK) yang terdiri atas 5 perlakuan dan 4 kelompok sebagai ulangan. Adapun perlakuan yang dicobakan meliputi: P1 = PK 12%; P2 = PK 14%; P3 = PK 16%; P4 = PK 18%; dan P5 = PK 20%. Variabel yang diamati dalam penelitian ini adalah perubahan dimensi tubuh (lingkar dada, panjang badan, tinggi pundak, tinggi pinggul) sapi Donggala induk muda. Hasil penelitian menunjukkan bahwa pemberian pakan dengan level PK  memberikan pengaruh yang nyata (p<0,05) terhadap peningkatan lingkar dada, peningkatan panjang badan, tinggi pundak, tinggi pinggul.  Peningkatan lingkar dada terendah dicapai pada P12 (20,7 cm) dan tertinggi pada P18 (32,0 cm).
DIAGNOSIS DEPRESI SEBAGAI PERSEPSI DARI ALAM BAWAH SADAR TOKOH UTAMA PADA CERPEN DURIAN KARYA DJENAR MAESA AYU
Authors: Anam Yuli Aisyah putri
Published: June 2023

This study aimed at analyzing a short story by Djenar Maesa Ayu in her book entitled Mereka Bilang, Saya Monyet. The short story discussed in this research was called Durian. The objective of this study was to reveal the triggers of mental disorders experienced by the main character in the short story Durian. The object of this research was Durian, with the psychology of Hyza as the formal object of this research. The short story Durian became a primary data source, and all articles related to Durian acted as secondary data sources. The data collection technique utilized in the recent study was analytical, including reading, listening, and taking notes. The research results revealed that the mental disorders experienced by Hyza's character came from past experiences that could not be resolved, so it accompanied the character's abnormal mental development. Those experiences triggered the character's subconscious desires that affect the character's conscious mind. Hallucinations and fears are a form of mental disorder as a result of the perception from the past experiences.
ENGLISH LEARNING DIFFICULTIES AT SMP NEGERI 23 TAKENGON DURING THE PANDEMIC
Authors: Amalia RakhmytaMRs. Yunie
Published: June 2023

This study described the difficulties faced by students in learning English during the pandemic at SMP Negeri 23 Takengon. The researchers applied a qualitative study with a phenomenological approach in this current research. Data were collected through several techniques comprising observation, interviews, and documentation. The study used three steps from Miles and Huberman's theory to analyze the data, including data reduction, data display, and conclusions. The results showed that the students face five difficulties in learning English amidst the pandemic comprising learning disorders, learning disabilities, learning dysfunctions, underachievers, and slow learners. Among those five, slow learners become the most dominant difficulty, while learning disorder is the least problematic aspect for the students. Several issues that are likely to cause difficulties are a continuous practice of multiple-choice questions without being given a context, avoiding class, lack of interest in learning English, weak ability to learn fast, and reduced learning hours.
TopDownApp: An open and modular platform for analysis and visualisation of top-down proteomics data
Authors: Walzer Mathias , Jeong Kyowon , Tabb David L. , Vizcaino Juan Antonio
Published: June 2023

Although Top-down (TD) proteomics techniques, aimed at the analysis of
intact proteins and proteoforms, are becoming increasingly popular,
efforts are needed at different levels to generalise its adoption. In
this context, there are numerous improvements that are possible in the
area of open science including the FAIR (Findability, Accessibility,
Interoperability and Reusability) data principles. These include e.g.
increased data sharing practices and availability of tailored open data
standards. Additionally, the field would benefit from the development of
open analysis workflows that can enable e.g. data reuse of public
datasets, something that is increasingly common in other proteomics
fields. We present an open and modular platform for the analysis and
visualisation of TD proteomics data called TopDownApp. It can be used as
a flexible analysis platform, through the use of a common workflow
engine, common data formats for input/output, and software
containerisation. It can also serve as a tool for visual inspection
through its simple setup. As a key point, it can also be used as a
development platform for new tools through the use of Python, a modular
design, software containerisation and common data formats. TopDownApp is
open source and freely available at:
https://github.com/mwalzer/TopDownApp.
Development of the InSynQ checklist: A tool for planning and reporting the synthesis questions in systematic reviews of interventions
Authors: Cumpston Miranda , McKenzie Joanne , Ryan Rebecca , Flemyng Ella , Thomas James , Brennan Sue
Published: June 2023

Introduction Methods guidance and appraisal tools for systematic reviews
require specification of the question and eligibility criteria for the
review (‘PICO for the review’). Less emphasis has been given to
specifying the question and criteria for each synthesis (‘PICO for each
synthesis’), yet decisions about which studies to include in each
synthesis can critically influence the utility and findings of a review.
This paper describes the rationale and methods for developing the InSynQ
(Intervention Synthesis Questions) tool for planning and reporting
synthesis questions in reviews of interventions. The aim is to provide
transparency about the basis of the tool and contribute to evidence on
methods for developing guidance for research conduct and reporting.
Methods Informed by EQUATOR Network methods, we (1) established a
project group; (2) examined reporting of the ‘PICO for each synthesis’
in published reviews; (3) reviewed existing reporting guidance and the
Cochrane Handbook for Systematic Reviews of Interventions; (4) drafted
items with elaboration, explanation and examples; (5) conducted
consultation meetings, an evaluation survey and pilot test; (6)
incorporated feedback. Results Existing reporting guidelines do not
distinguish the review and synthesis PICO, with limited coverage of the
elements needed to specify the PICO for each synthesis. Using the PRISMA
2020 format, the draft tool contained 10 items with essential and
additional reporting elements, explanation and examples. Revisions
arising from feedback (>30 people), included adding an
eleventh item on consumer and stakeholder involvement, a figure
explaining PICO for each synthesis, and integrating examples into
elements/explanations. All respondents to the evaluation survey (12
people) said the tool would help them plan or appraise synthesis
questions. InSynQ is available at https://InSynQ.info. Conclusion
Transparent reporting of the development process contributes to the
evidence-base for methods to develop guidance. It may improve uptake of
InSynQ, in turn enhancing the clarity of syntheses.
Optimal Configuration and Dimension of Active Power Filters in Distribution Networks Based on Improved Beluga Whale Optimization
Authors: Tang bo , Liang haidong , Yue xiwen , ruijin Zhu
Published: June 2023

With the widespread use of electric vehicles, the rapid development of
power electronics and smart grids making more and more nonlinear devices
connected to the grid, the power quality problem is becoming more and
more prominent, and active power filters (APFs) are widely used to
reduce the harmonic voltage and current in the grid. In this paper, the
optimal configuration and dimensions of APFs for distribution networks
based on the improved Beluga whale optimization (IBWO) are proposed. The
IBWO algorithm proposed in this paper is characterized by fast
convergence and high accuracy. The objective of the method proposed in
this paper is to reduce the number of APFs used and the investment cost,
while making the total voltage harmonic distortion rate (VTHD) and the
individual VTHD of the grid meet the requirements. Finally, this paper
verifies the effectiveness and feasibility of the proposed method by an
example in an IEEE-18 bus test system, and the results show that the
proposed method is effective in optimizing the location and capacity of
multiple APFs.
Low-energy driven ring-opening behavior of benzocyclobutene derivatives
Authors: Yuan Ziwei , Sun Quan , Xiao Jinchong , Zhang Pingxia , Levchenko Konstantin , Demin Dmitry , Fu Wenxin
Published: June 2023

It’s urgent to develop benzocyclobutene (BCB)-based polymers with low
curing temperatures for temperature-sensitive applications such as
liquid crystal display (LCD) and flexible electronics. Herein, the
effect of substituents on the ring-opening behavior of BCB derivatives
was investigated. The ring-opening activation energy barriers (ΔGA) of
BCB derivatives with one or two substituents on the four-membered alkyl
ring were systematically calculated using the B3LYP function. Both mono-
and di-substituted BCBs adopted the conrotatory ring-opening process,
obeying the Woodward-Hoffmann’s Rules upon heating. The
mono-/di-substituted BCBs ex-hibited 8.2 – 69% lower ΔGA compared with
BCB, attributed to the electronic effects of the substituents.
Disubstituted BCBs with both electron-donating and electron-withdrawing
groups, e.g., 1-NH2-8-NO2-BCB, demonstrated the lowest ΔGA. In addition,
BCB derivatives with amide/ester/acyloxy group modified on C1 position
were synthesized as model molecules, and their ring-opening temperature
can be decreased by 20 °C compared to the unsubstituted one, also
consistent with our calculation results. This work combined the
theoretical calculation method with experimental results to provide
valuable insights into the design and synthesis of BCB derivatives and
next-generation BCB functional packaging materials with low ring-opening
temperatures.