bluuebunny/crossref_metadata_2025 huggingface dataset:
Control over the Surface Properties of Zinc Oxide Powders via Combining Mechanical, Electron Beam, and Thermal Processing
Authors: Pronin Igor A. , Averin Igor A. , Karmanov Andrey A. , Yakushova Nadezhda D. , Komolov Alexey S. , Lazneva Eleonora F. , Sychev Maxim M. , Moshnikov Vyacheslav A. , Korotcenkov Ghenadii
Published: June 2022

The surface properties of zinc oxide powders prepared using mechanical activation, electron beam irradiation, and vacuum annealing, as well using combinations of these types of treatments, were studied using X-ray photoelectron spectroscopy. The structure of the obtained materials was studied by an X-ray diffraction technique and by scanning electron microscopy. We found that over five hours of grinding in an attritor, the size of nanocrystals decreases from 37 to 21 nm, and microdeformations increase from 0.3% to 0.6%. It was also found that a five-hour grinding treatment promoted formation of vacancies in the zinc sublattice at the surface and diffusion of Zn2+ cations into the bulk of the material. Irradiation of commercial zinc oxide powders with an electron beam with an energy of 0.9 MeV and a dose of 1 MGy induced breaking of Zn–O bonds, diffusion of interstitial zinc ions into the bulk, and oxygen atom escape from regular positions into the gas phase. A combined treatment of five hours of grinding and electron beam irradiation promoted accumulation of interstitial zinc ions at the surface of the material. Annealing of both initial and mechanically activated ZnO powders at temperatures up to 400 °C did not lead to a significant change in the properties of the samples. Upon exceeding the 400 °C annealing temperature the X-ray photoelectron spectra show almost identical atomic composition of the two types of materials, which is related to diffusion of interstitial zinc ions from the bulk of the material to the surface.
Nanohollow Titanium Oxide Structures on Ti/FTO Glass Formed by Step-Bias Anodic Oxidation for Photoelectrochemical Enhancement
Authors: Huang Chi-Hsien , Lu Yu-Jen , Pan Yong-Chen , Liu Hui-Ling , Chang Jia-Yuan , Sie Jhao-Liang , Pijanowska Dorota G. , Yang Chia-Ming
Published: June 2022

In this study, a new anodic oxidation with a step-bias increment is proposed to evaluate oxidized titanium (Ti) nanostructures on transparent fluorine-doped tin oxide (FTO) on glass. The optimal Ti thickness was determined to be 130 nm. Compared to the use of a conventional constant bias of 25 V, a bias ranging from 5 V to 20 V with a step size of 5 V for 3 min per period can be used to prepare a titanium oxide (TiOx) layer with nanohollows that shows a large increase in current of 142% under UV illumination provided by a 365 nm LED at a power of 83 mW. Based on AFM and SEM, the TiOx grains formed in the step-bias anodic oxidation were found to lead to nanohollow generation. Results obtained from EDS mapping, HR-TEM and XPS all verified the TiOx composition and supported nanohollow formation. The nanohollows formed in a thin TiOx layer can lead to a high surface roughness and photon absorbance for photocurrent generation. With this step-bias anodic oxidation methodology, TiOx with nanohollows can be obtained easily without any extra cost for realizing a high current under photoelectrochemical measurements that shows potential for electrochemical-based sensing applications.
Utilization of Carbon-Based Nanomaterials and Plate-Fin Networks in a Cold PCM Container with Application in Air Conditioning of Buildings
Authors: Afsharpanah Farhad , Cheraghian Goshtasp , Akbarzadeh Hamedani Farzam , Shokri Elham , Mousavi Ajarostaghi Seyed Soheil
Published: June 2022

Cold energy storage devices are widely used for coping with the mismatch between thermal energy production and demand. These devices can store cold thermal energy and return it when required. Besides the countless advantages of these devices, their freezing rate is sluggish, therefore researchers are continuously searching for techniques to improve their operating speed. This paper tries to address this problem by simultaneously combining a network of plate fins and various types of carbon-based nanomaterials (NMs) in a series of complex computational fluid dynamics (CFD) simulations that are validated by published experimental results. Horizontal, vertical, and the combination of these two plate-fin arrangements are tested and compared to the base model. Subsequently, several carbon-based NMs, including SWCNT, MWCNT, and graphene-oxide NMs are utilized to further improve the process. The influence of these fin networks, nanoparticle types, and their volume- and mass-based concentrations within the PCM container are studied and discussed. According to the results, carbon-based NMs exhibit superior performance compared to metal-oxide NMs, so that at identical NM volume and mass fractions, MWCNT particles present a 2.77% and 17.72% faster freezing rate than the CuO particles. The combination of plate-fin network and MWCNT particles is a promising technique that can expedite the ice formation rate by up to 70.14%.
Recommendations for the Development of Family-Based Interventions Aiming to Prevent Unhealthy Changes in Energy Balance-Related Behavior during the Transition to Parenthood: A Focus Group Study
Authors: Versele Vickà , Deforche Benedicte , Aerenhouts Dirk , Clarys Peter , Devlieger Roland , Bogaerts Annick , Liel Christoph , Löchner Johanna , Wolstein Jörg , van Poppel Mireille , Deliens Tom
Published: June 2022

Feasible interventions addressing unhealthy changes in energy balance-related behavior (EBRB) during pregnancy and early postpartum are needed. This study identified the needs and wishes of expecting and first-time parents concerning EBRB interventions during the transition to parenthood. Thirteen focus group discussions (n = 74) were conducted. Couples provided information about whether an intervention targeting unhealthy EBRB changes during pregnancy and postpartum would be acceptable, how such an intervention should look like, and in which way and during which period they needed support. Guided by the TiDIER checklist, all quotes were divided into five main categories (i.e., ‘what’, ‘how’, ‘when and how much’, ‘where’, ‘for and from whom’). Interventions should aim for changes at the individual, social, environmental and policy levels. The accessibility and approach (indirect or face-to-face) together with communicational aspects should be taken into account. A focus should go to delivering reliable and personalized information and improving self-regulation skills. Interventions should be couple- or family-based. Authorities, healthcare professionals, the partner and peers are important sources for intervention delivery and support. In the prevention of unhealthy EBRB changes around childbirth, the involvement of both parents is needed, while health care professionals play an important role in providing personalized advice.
Nocturnal Lifestyle Behaviours and Risk of Poor Sleep during Pregnancy
Authors: Ku Chee Wai , Loo Rachael Si Xuan , Tiong Michelle Mei Ying , Eng Sing Yee Clara , Cheung Yin Bun , Ong Lay See , Tan Kok Hian , Chong Mary Foong-Fong , Chan Jerry Kok Yen , Yap Fabian , Loy See Ling
Published: June 2022

The extent to which lifestyle practices at night influence sleep quality in pregnant women remains unknown. This study aimed to examine whether nocturnal behaviours were associated with poor sleep during pregnancy. We performed a cross-sectional analysis of a prospective cohort of pregnant women at 18–24 gestation weeks recruited from KK Women’s and Children’s Hospital, Singapore, between 2019 and 2021. Nocturnal behaviours were assessed with questionnaires, and sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI) with a global score ≥5 indicative of poor sleep quality. Modified Poisson regression and linear regression were used to examine the association between nocturnal behaviour and sleep quality. Of 299 women, 117 (39.1%) experienced poor sleep. In the covariate-adjusted analysis, poor sleep was observed in women with nocturnal eating (risk ratio 1.51; 95% confidence interval [CI] 1.12, 2.04) and nocturnal artificial light exposure (1.63; 1.24, 2.13). Similarly, nocturnal eating (β 0.68; 95% CI 0.03, 1.32) and light exposure (1.99; 1.04, 2.94) were associated with higher PSQI score. Nocturnal physical activity and screen viewing before bedtime were not associated with sleep quality. In conclusion, reducing nocturnal eating and light exposure at night could potentially improve sleep in pregnancy.
A Preliminary Study of Proinflammatory Cytokines and Depression Following West Nile Virus Infection
Authors: Lino Allison , Erickson Timothy A. , Nolan Melissa S. , Murray Kristy O. , Ronca Shannon E.
Published: June 2022

West Nile virus (WNV) is a neurotropic flavivirus that can cause acute febrile illness leading to neuroinvasive disease. Depression is a well-described outcome following infection, but the underlying pathogenic mechanisms are unknown. Proinflammatory cytokines play important roles in WNV infection, but their role in depression post-WNV remains unstudied. This research aimed to retrospectively evaluate associations between proinflammatory cytokines and new onset depression in a WNV cohort. Participants with asymptomatic WNV infection were significantly less likely to report new onset depression when compared to those with symptomatic disease. Participants with encephalitis and obesity were significantly more likely to report new onset depression post-infection. Based on univariate analysis of 15 antiviral or proinflammatory cytokines, depression was associated with elevated MCP-1 and decreased TNFα, whereas G-CSF was significantly elevated in those with a history of neuroinvasive WNV. However, no cytokines were statistically significant after adjusting for multiple comparisons using the Bonferroni method. While symptomatic WNV infection, encephalitis, and obesity were associated with new onset depression following infection, the role of proinflammatory cytokines requires additional studies. Further research involving paired acute-convalescent samples, larger sample sizes, and additional data points would provide additional insight into the impact of the inflammatory response on WNV-mediated depression.
The Tails of Two Avian Schistosomes: Paired Exposure Study Demonstrates Trichobilharzia stagnicolae Penetrates Human Skin More Readily than a Novel Avian Schistosome from Planorbella
Authors: Anderson Nathaniel J. , Blankespoor Curtis L. , DeJong Randall J.
Published: June 2022

A novel schistosome from Planorbella snails currently known as avian schistosomatid sp. C (ASC) was recently described as being capable of causing the papules associated with swimmer’s itch. We conducted a paired study with 24 human volunteers, exposing each of their forearms to five drops of water containing cercariae of ASC or Trichobilharzia stagnicolae, and examined the skin for papules 1–3 days later. A mixed effects model showed that only the parasite species significantly affected the number of papules, while prior experimental exposure, swimming history, and swimmer’s itch experience did not. The total number of papules produced by the two species were very different: ASC produced a total of 2 papules from the 298 cercariae used, compared to 49 papules from 160 T. stagnicolae cercariae, a difference factor of more than 43X, which was comparable to the odds ratio of 45.5 computed using the statistical model. A well-known agent of swimmer’s itch, T. stagnicolae, is able to penetrate human skin more frequently than ASC, likely meaning that ASC is only a minor cause of swimmer’s itch where T. stagnicolae is present. We also completed limited experiments that compared the cercarial behavior of the two species in vitro and in situ. A known stimulant of schistosome cercarial penetration, α-linolenic acid, did not stimulate ASC cercariae to initiate penetration-associated behaviors as frequently as T. stagnicolae. However, when placed on esophageal tissue of the known vertebrate host for ASC, Canada goose (Branta canadensis), ASC cercariae were observed penetrating the esophageal epithelium quickly, whereas T. stagnicolae cercariae did not exhibit any penetration behaviors.
Synthesis of Coumarin and Homoisoflavonoid Derivatives and Analogs: The Search for New Antifungal Agents
Authors: Ferreira Alana R. , Alves Danielle da N. , de Castro Ricardo D. , Perez-Castillo Yunierkis , de Sousa Damião P.
Published: June 2022

A set of twenty-four synthetic derivatives, with coumarin and homoisoflavonoid cores and structural analogs, were submitted for evaluation of antifungal activity against various species of Candida. The broth microdilution test was used to determine the Minimum Inhibitory Concentration (MIC) of the compounds and to verify the possible antifungal action mechanisms. The synthetic derivatives were obtained using various reaction methods, and six new compounds were obtained. The structures of the synthesized products were characterized by FTIR spectroscopy: 1H-NMR, 13C-NMR, and HRMS. The coumarin derivative 8 presented the best antifungal profile, suggesting that the pentyloxy substituent at the C-7 position of coumarin ring could potentiate the bioactivity. Compound 8 was then evaluated against the biofilm of C. tropicalis ATCC 13803, which showed a statistically significant reduction in biofilm at concentrations of 0.268 µmol/mL and 0.067 µmol/mL, when compared to the growth control group. For a better understanding of their antifungal activity, compounds 8 and 21 were submitted to a study of the mode of action on the fungal cell wall and plasma membrane. It was observed that neither compound interacted directly with ergosterol present in the fungal plasma membrane or with the fungal cell wall. This suggests that their bioactivity was due to interaction involving other pharmacological targets. Compound 8 was also subjected to a molecular modeling study, which showed that its antifungal action mechanism occurred mainly through interference in the redox balance of the fungal cell, and by compromising the plasma membrane; not by direct interaction, but by interference in ergosterol synthesis. Another important finding was the antifungal capacity of homoisoflavonoids 23 and 24. Derivative 23 presented slightly higher antifungal activity, possibly due to the presence of the methoxyl substituent in the meta position in ring B.
Safety of Antibiotics in Hospitalized Children in Romania: A Prospective Observational Study
Authors: Bulik Noémi-Beátrix , Farcaș Andreea , Bucșa Camelia , Iaru Irina , Oniga Ovidiu
Published: June 2022

Antibiotics are among the most prescribed drugs in pediatric inpatients and are frequently associated with adverse drug reactions (ADRs) in children. This study aimed to assess the frequency and type of ADRs related to the use of antibiotics in pediatric inpatients through a prospective observational study, conducted over 6 months, covering the winter and spring seasons when the incidence of infections peaks in Romania. ADRs were evaluated for causality, avoidability and severity. Among the 266 included children, 25 (9.4%) experienced 30 ADRs. ADR frequency tended to be higher in ≤2-year-olds (13 of 25, 52.0%) than in other age categories. Gastrointestinal and hematological ADRs were most frequently observed. Diarrhea was the most common ADR associated with antibiotics (8 of 30, 26.7%). Ceftriaxone (16 of 30, 53.3%), cefuroxime, ceftazidime and azithromycin (3 of 30, 10.0% each) were most commonly responsible for ADRs. After causality assessment, 2 (6.7%) ADRs were considered definite, 12 (40.0%) probable and 16 (53.3%) possible. One ADR was classified as definitely avoidable and one as possibly avoidable. Seven children required treatment for ADRs. Antibiotic treatment was discontinued in 4 children. Antibiotics frequently caused ADRs in ≤ 2-year-olds and were commonly associated with gastrointestinal symptoms. Close monitoring of antibiotic-associated ADRs remains important in the pediatric population.
WPI Hydrogels with a Prolonged Drug-Release Profile for Antimicrobial Therapy
Authors: Plastun Valentina O. , Prikhozhdenko Ekaterina S. , Gusliakova Olga I. , Raikova Svetlana V. , Douglas Timothy E. L. , Sindeeva Olga A. , Mayorova Oksana A.
Published: June 2022

Infectious sequelae caused by surgery are a significant problem in modern medicine due to their reduction of therapeutic effectiveness and the patients’ quality of life.Recently, new methods of local antimicrobial prophylaxis of postoperative sequelae have been actively developed. They allow high local concentrations of drugs to be achieved, increasing the antibiotic therapy’s effectiveness while reducing its side effects. We have developed and characterized antimicrobial hydrogels based on an inexpensive and biocompatible natural substance from the dairy industry—whey protein isolate—as matrices for drug delivery. The release of cefazolin from the pores of hydrogel structures directly depends on the amount of the loaded drug and occurs in a prolonged manner for three days. Simultaneously with the antibiotic release, hydrogel swelling and partial degradation occurs. The WPI hydrogels absorb solvent, doubling in size in three days and retaining cefazolin throughout the duration of the experiment. The antimicrobial activity of cefazolin-loaded WPI hydrogels against Staphylococcus aureus growth is prolonged in comparison to that of the free cefazolin. The overall cytotoxic effect of cefazolin-containing WPI hydrogels is lower than that of free antibiotics. Thus, our work shows that antimicrobial WPI hydrogels are suitable candidates for local antibiotic therapy of infectious surgical sequelae.
Cu2+-Chelating Mesoporous Silica Nanoparticles for Synergistic Chemotherapy/Chemodynamic Therapy
Authors: Zhang Yanyan , Lou Jiadong , Williams Gareth R. , Ye Yuhan , Ren Dandan , Shi Anhua , Wu Junzi , Chen Wenling , Zhu Li-Min
Published: June 2022

In this study, a pH-responsive controlled-release mesoporous silica nanoparticle (MSN) formulation was developed. The MSNs were functionalized with a histidine (His)-tagged targeting peptide (B3int) through an amide bond, and loaded with an anticancer drug (cisplatin (CP)) and a lysosomal destabilization mediator (chloroquine (CQ)). Cu2+ was then used to seal the pores of the MSNs via chelation with the His-tag. The resultant nanoparticles showed pH-responsive drug release, and could effectively target tumor cells via the targeting effect of B3int. The presence of CP and Cu2+ permits reactive oxygen species to be generated inside cells; thus, the chemotherapeutic effect of CP is augmented by chemodynamic therapy. In vitro and in vivo experiments showed that the nanoparticles are able to effectively kill tumor cells. An in vivo cancer model revealed that the nanoparticles increase apoptosis in tumor cells, and thereby diminish the tumor volume. No off-target toxicity was noted. It thus appears that the functionalized MSNs developed in this work have great potential for targeted, synergistic anticancer therapies.
HPMA Copolymer Mebendazole Conjugate Allows Systemic Administration and Possesses Antitumour Activity In Vivo
Authors: Studenovský Martin , Rumlerová Anna , Kovářová Jiřina , Dvořáková Barbora , Sivák Ladislav , Kostka Libor , Berdár Daniel , Etrych Tomáš , Kovář Marek
Published: June 2022

Mebendazole and other benzimidazole antihelmintics, such as albendazole, fenbendazole, or flubendazole, have been shown to possess antitumour activity, primarily due to their microtubule-disrupting activity. However, the extremely poor water-solubility of mebendazole and other benzimidazoles, resulting in very low bioavailability, is a serious drawback of this class of drugs. Thus, the investigation of their antitumour potential has been limited so far to administering repeated high doses given peroral (p.o.) or to using formulations, such as liposomes. Herein, we report a fully biocompatible, water-soluble, HPMA copolymer-based conjugate bearing mebendazole (P-MBZ; Mw 28–33 kDa) covalently attached through a biodegradable bond, enabling systemic administration. Such an approach not only dramatically improves mebendazole solubility but also significantly prolongs the half-life and ensures tumour accumulation via an enhanced permeation and retention (EPR) effect in vivo. This P-MBZ has remarkable cytostatic and cytotoxic activities in EL-4 T-cell lymphoma, LL2 lung carcinoma, and CT-26 colon carcinoma mouse cell lines in vitro, with corresponding IC50 values of 1.07, 1.51, and 0.814 µM, respectively. P-MBZ also demonstrated considerable antitumour activity in EL-4 tumour-bearing mice when administered intraperitoneal (i.p.), either as a single dose or using 3 intermittent doses. The combination of P-MBZ with immunotherapy based on complexes of IL-2 and anti-IL-2 mAb S4B6, potently stimulating activated and memory CD8+ T cells, as well as NK cells, further improved the therapeutic effect.
A 102 W High-Power Linearly-Polarized All-Fiber Single-Frequency Laser at 1560 nm
Authors: Huang Jiamin , Zhao Qilai , Zheng Junjie , Huang Chengzi , Gu Quan , Jiang Wanpeng , Zhou Kaijun , Yang Changsheng , Feng Zhouming , Zhang Qinyuan , Yang Zhongmin , Xu Shanhui
Published: June 2022

A 1560 nm high-power linearly-polarized all-fiber single-frequency narrow-linewidth laser with near diffraction-limited beam quality is demonstrated. The Yb–Er energy transfer efficiency and the ability of the signal laser to capture pump light have been improved by specifically choosing the pumping wavelength and the input signal power in the final power amplifier stage of this laser system. Under the off-peak absorption pumping wavelength of 940 nm, along with the maximum input signal power of 6 W, a maximum output power of 102 W with a slope efficiency of 40.5% is acquired. At the highest output power status, a polarization extinction ratio (PER) of 15.5 dB, a linewidth of 3.05 kHz, and a beam quality of Mx2 = 1.14, My2 = 1.06 are obtained, respectively. This advanced single-frequency fiber laser has great potential for the long-range coherent Doppler lidar and the next generation of gravitational wave detection.
Partial Amplification of Octave-Spanning Supercontinuum in the Spectral Region of 1.5–2.2 μm
Authors: Zhluktova Irina V. , Zverev Andrei D. , Filatova Serafima A. , Kamynin Vladimir A. , Sysoliatin Alexej A. , Tsvetkov Vladimir B.
Published: June 2022

Octave-spanning supercontinuum conversion in three different rare-earth doped fiber amplifiers have been investigated. Using an erbium amplifier, it turned out to increase the output power to 445 mW with a spectral width of 1250 nm. For a thulium amplifier, an average output power of 390 mW and a spectral width of 569 nm was obtained. Additionally, for holmium, the average output power was 724 mW with a spectral width of 450 nm. For all cases, the output pulses envelope did not exceed 0.72 ns.
Role of Litsea cubeba Essential Oil in Agricultural Products Safety: Antioxidant and Antimicrobial Applications
Authors: Borotová Petra , Galovičová Lucia , Vukovic Nenad L. , Vukic Milena , Kunová Simona , Hanus Paweł , Kowalczewski Przemysław Łukasz , Bakay Ladislav , Kačániová Miroslava
Published: June 2022

The essential oil from Litsea cubeba (LCEO) has good antioxidant, antimicrobial, anti-insect properties, which gives it the potential for use as a natural additive to food resources and food products in order to prevent spoilage and extend shelf life. In this study the biological activity related to food preservation was observed. The main volatile organic compounds were geranial (39.4%), neral (29.5%), and limonene (14.3%). Antioxidant activity was 30.9%, which was equal to 167.94 µg of Trolox per mL of sample. Antimicrobial activity showed the strongest inhibition against Serratia marcescens by disk diffusion method and minimum inhibitory concentrations MIC 50 and MIC 90 were the lowest for Micrococcus luteus with values 1.46 and 3.52 µL/mL, respectively. Antimicrobial activity of the LCEO vapor phase showed strong inhibition of microorganisms on apples, pears, potatoes, and kohlrabies. Over 50% of gram-positive and gram-negative bacteria and yeasts were inhibited by a concentration of 500 µL/mL. The inhibition of microorganisms was concentration dependent. Anti-insect activity was also strong, with 100% lethality of Pyrrhocoris apterus at a concentration of 25%. These results suggest that LCEO could be potentially used as a food preservative.
Combined LC-MS/MS and Molecular Networking Approach Reveals Antioxidant and Antimicrobial Compounds from Erismadelphus exsul Bark
Authors: Essono Mintsa Morel , Otogo N’nang Elvis , Choque Élodie , Siah Ali , Jacquin Justine , Muchembled Jerome , Molinié Roland , Roulard Romain , Cailleu Dominique , Beniddir Mehdi A. , Sima Obiang Cédric , Ondo Joseph-Privat , Kumulungui Brice , Mesnard François
Published: June 2022

Erismadelphus exsul Mildbr bark is widely used in Gabonese folk medicine. However, little is known about the active compounds associated with its biological activities. In the present study, phytochemical profiling of the ethanolic extract of Erismadelphus exsul was performed using a de-replication strategy by coupling HPLC-ESI-Q/TOF with a molecular network approach. Eight families of natural compounds were putatively identified, including cyclopeptide alkaloids, esterified amino acids, isoflavonoid- and flavonoid-type polyphenols, glycerophospholipids, steroids and their derivatives, and quinoline alkaloids. All these compounds were identified for the first time in this plant. The use of molecular networking obtained a detailed phytochemical overview of this species. Furthermore, antioxidant (2,2-diphenyl-1-picryl-hydrazylhydrate (DPPH) and ferric reducing capacity (FRAP)) and in vitro antimicrobial activities were assessed. The crude extract, as well as fractions obtained from Erismadelphus exsul, showed a better reactivity to FRAP than DPPH. The fractions were two to four times more antioxidant than ascorbic acid while reacting to FRAP, and there was two to nine times less antioxidant than this reference while reacting to DPPH. In addition, several fractions and the crude extract exhibited a significant anti-oomycete activity towards the Solanaceae phytopathogen Phytophthora infestans in vitro, and, at a lower extent, the antifungal activity against the wheat pathogen Zymoseptoria tritici had growth inhibition rates ranging from 0 to 100%, depending on the tested concentration. This study provides new insights into the phytochemical characterization and the bioactivities of ethanolic extract from Erismadelphus exsul bark.
Study on the Synthesis and Properties of Waterborne Polyurea Modified by Epoxy Resin
Authors: Wang Jing , Wang Jihu , Wang Song , Wen Shaoguo , Chen Kaimin , Xie Chen , Yuan Chunping
Published: June 2022

The most notable features of polyurea are its fast reaction, energy-saving and high efficiency. In order to meet the needs of environmental protection, waterborne polyurea (WPUA) has become a research hotspot. However, the presence of hydrophilic groups in WPUA reduces its solvent resistance, heat resistance and mechanical properties. Therefore, it is necessary and valuable to develop a high-performance WPUA. In this study, epoxy-modified waterborne polyurea (WPUAE) emulsions were prepared using epoxy resin as a modifier. Fourier transform infrared spectroscopy (FT-IR) showed that E44 was successfully introduced into the molecular chain of WPUA. The WPUAE was tested for gel fraction, adhesion, contact angle, solvent resistance, tensile properties and thermal stability. The results showed that when the E44 content was 8 wt%, the performance of WPUAE was best, the adhesion of WPUAE coating film was 1.53 MPa, the gel fraction, water contact angle, water absorption, toluene absorption, tensile strength and decomposition temperature were 96.94%, 70.3°, 16.43%, 131.04%, 9.05 MPa and 365 °C, respectively. The results showed that epoxy resin as an emulsion modifier improved the comprehensive properties of WPUA.
Facile Fabrication of Cellulose Nanofibrils/Chitosan Beads as the Potential pH-Sensitive Drug Carriers
Authors: Wu Meiyan , Deng Wangfang , Zhang Yidong , Chen Chao , Liu Zhexuan , Fatehi Pedram , Li Bin
Published: June 2022

It is highly desirable to develop a safe, highly efficient, and biodegradable drug carrier with an enhanced drug transport efficiency. Cellulose nanofibrils (CNF) and chitosan (CS) composite hydrogels are promising candidate carriers with biological compatibility and non-cytotoxicity. Herein, the CNF/CS composite beads were prepared by dissolving cellulose and CS in LiBr molten salt hydrate and regenerating in ethanol. This preparation method is facile and efficient, and the obtained porous CNF/CS beads with the weight ratio of 8:2 exhibited a large specific surface area, uniform micro-nano-sized pores, strong mechanical property, and water absorption-resistance. Moreover, these beads as drug (tetracycline hydrochloride, TH) carriers showed a higher encapsulation efficiency (47.4%) at the TH concentration of 5 mg/mL in 24 h, and a higher drug loading rate (12.0%) than pure CNF and other CNF/CS beads prepared with different ratios. In addition, the TH releasing behavior of CNF/CS (8:2) beads fitted well into the zero-order, first-order, and Higuchi models under an acid condition, indicating that the drug release of these pH-sensitive beads was mainly affected by drug concentration under an acid condition. Therefore, these CNF/CS beads have great potential to be used as drug carriers for medical applications.
Biopolymeric Nanoparticles–Multifunctional Materials of the Future
Authors: Vodyashkin Andrey , Kezimana Parfait , Vetcher Alexandre , Stanishevskiy Yaroslav
Published: June 2022

Nanotechnology plays an important role in biological research, especially in the development of delivery systems with lower toxicity and greater efficiency. These include not only metallic nanoparticles, but also biopolymeric nanoparticles. Biopolymeric nanoparticles (BPNs) are mainly developed for their provision of several advantages, such as biocompatibility, biodegradability, and minimal toxicity, in addition to the general advantages of nanoparticles. Therefore, given that biopolymers are biodegradable, natural, and environmentally friendly, they have attracted great attention due to their multiple applications in biomedicine, such as drug delivery, antibacterial activity, etc. This review on biopolymeric nanoparticles highlights their various synthesis methods, such as the ionic gelation method, nanoprecipitation method, and microemulsion method. In addition, the review also covers the applications of biodegradable polymeric nanoparticles in different areas—especially in the pharmaceutical, biomedical, and agricultural domains. In conclusion, the present review highlights recent advances in the synthesis and applications of biopolymeric nanoparticles and presents both fundamental and applied aspects that can be used for further development in the field of biopolymeric nanoparticles.
Controlling Morphology and Physio-Chemical Properties of Stimulus-Responsive Polyurethane Foams by Altering Chemical Blowing Agent Content
Authors: Hasan Sayyeda Marziya , Touchet Tyler , Jayadeep Aishwarya , Maitland Duncan J.
Published: June 2022

Amorphous shape memory polymer foams are currently used as components in vascular occlusion medical devices such as the IMPEDE and IMPEDE-FX Embolization Plugs. Body temperature and moisture-driven actuation of the polymeric foam is necessary for vessel occlusion and the rate of expansion is a function of physio-chemical material properties. In this study, concentrations of the chemical blowing agent for the foam were altered and the resulting effects on morphology, thermal and chemical properties, and actuation rates were studied. Lower concentration of chemical blowing agent yielded foams with thick foam struts due to less bubble formation during the foaming process. Foams with thicker struts also had high tensile modulus and lower strain at break values compared to the foams made with higher blowing agent concentration. Additionally, less blowing agent resulted in foams with a lower glass transition temperature due to less urea formation during the foaming reaction. This exploratory study provides an approach to control thermo-mechanical foam properties and morphology by tuning concentrations of a foaming additive. This work aims to broaden the applications of shape memory polymer foams for medical use.
The Seal Performance of Compliant Foil Gas Seal Based on Multi-Scale Analysis
Authors: Wang Xueliang , Liu Meihong
Published: June 2022

Compliant foil gas seal is a non-contact and high-efficiency sealing technology. The dynamic performance of compliant foil gas seal with different structure parameters was analyzed in this paper. These parameters include the seal diameter, gas film thickness and the ratio of groove. Compared with the rigid film, the advantage of compliant film is analyzed. The stability performance and dynamic performance with the different structures are obtained. The results show that the larger diameter is a disadvantage for the stability performance. However, the increase of seal length can decrease the leakage. Otherwise, the increase of gas thickness improves the dynamic characteristics with the leakage rising and gas force dramatically decreasing. While the groove length ratio is around 0.6, the seal performance and dynamic characteristics are best. The compliant structure benefits the improvement of the sealing performance.
Optimization of Microalgal Harvesting with Inorganic and Organic Flocculants Using Factorial Design of Experiments
Authors: Machado Cláudia A. , Esteves Ana F. , Pires José C. M.
Published: June 2022

Microalgae have a lot of potential as a source of several compounds of interest to various industries. However, developing a sustainable and efficient harvesting process on a large scale is still a major challenge. This is particularly a problem when the production of low-value products is intended. Chemical flocculation, followed by sedimentation, is seen as an alternative method to improve the energetic and economic balance of the harvesting step. In this study, inorganic (aluminum sulfate, ferric sulfate, ferric chloride) and organic (Zetag 8185, chitosan, Tanfloc SG) flocculants were tested to harvest Chlorella vulgaris in batch mode. Preliminary assays were conducted to determine the minimum dosages of each flocculant that generates primary flocs at different pH. Except for chitosan, the organic flocculants required small dosages to initiate floc formation. Additional studies were performed for the flocculants with a better performance in the preliminary assays. Zetag 8185 had the best results, reaching 98.8% and 97.9% efficiencies with dosages of 50 and 100 mg L−1, respectively. Lastly, a 24 full factorial design experiment was performed to determine the effects of the flocculant dosage, settling time, and mixing time on the Zetag 8185 harvesting efficiency. The harvesting efficiency of C. vulgaris was optimal at a dosage of 100 mg L−1 and 3 min of rapid mixing.
Assessment of Deep and Shallow Geothermal Resources and Measurement of Waste Heat Potentials from Industrial Processes for Supplying Renewable Heat for Industry and Urban Quarters
Authors: Haslinger Edith , Turewicz Veronika , Hammer Andreas , Götzl Gregor
Published: June 2022

Deep geothermal resources for heat supply and waste heat potentials were assessed and measured for a high-temperature dairy plant. For the industrial waste heat, a borehole heat exchanger (BHE) seasonal storage was configured and simulated after an extensive investigation of shallow geothermal resources. We developed a concept for the subsequent use of the residual and waste heat from the plant in a low-temperature heating and cooling (LTHC) grid for the neighbouring former military camp “Martinek-Kaserne” with a future use as mixed-use urban quarter were investigated in two projects. The modelling of the deep geothermal resources showed that of the three potential reservoirs one is most feasible for geothermal heat supply with temperatures between 129 and 146 °C, which could be used with a high-temperature heat pump for process heat. The waste heat in all sub-processes of the dairy plant were measured over 18 months to identify the most suitable waste heat streams with regard to temperature and continuity. The results showed that 25 % of the waste heat from a sub-process of the plant (fresh products logistics) is sufficient to provide heat for the adjacent LTHC grid with a total energy demand of 3428 MWh per year. The simulation of the BHE field resulted in 96 BHE with 180 m depth for a dis-/charging capacity of 643.7 MWh and 20 decentral heat pumps in the buildings. The BHE field operates quite balanced with only 12.8 MWh of difference in the annual balance. The results of the feasibility study for deep and shallow geothermal resources, and the assessment of the industrial waste heat show that the whole cascade of high-temperature heat for industry to low-temperature heat for the LTHC grid could be realized at the investigated site.
A Smart Procedure for Assessing the Health Status of Terrestrial Habitats in Protected Areas: The Case of the Natura 2000 Ecological Network in Basilicata (Southern Italy)
Authors: Imbrenda Vito , Lanfredi Maria , Coluzzi Rosa , Simoniello Tiziana
Published: June 2022

Natura 2000 is the largest coordinated network of protected areas in the world, which has been established to preserve rare habitats and threatened species at the European Community level. Generally, tools for habitat quality assessment are based on the analyses of land-use/land-cover changes, thus, highlighting already overt habitat modifications. To evaluate the general quality conditions of terrestrial habitats and detect habitat degradation processes at an early stage, a direct and cost-effective procedure based on satellite imagery (Landsat data) and GIS (Geographic Information System) tools is proposed. It focuses on the detection of anomalies in vegetation matrix (stress/fragmentation), estimated for each habitat at the level of both a single protected site and local network, to identify habitat priority areas (HPA), i.e., areas needing priority interventions, and to support a rational use of resources (field surveys, recovery actions). By analyzing the statistical distributions of standardized NDVI for all the enclosed habitats (at the site or network level), the Degree of Habitat Consistency (DHC) was also defined. The index allows the assessment of the general status of a protected site/network, and the comparison of the environmental conditions of a certain habitat within a given protected site (SCI, SAC) with those belonging to the other sites of the network. The procedure was tested over the Natura 2000 network of the Basilicata region (Southern Italy), considered as a hotspot of great natural and landscape interest. An overall accuracy of ~97% was obtained, with quite low percentages of commission (~8%) and omission (~6%) errors. By examining the diachronic evolution (1985–2009) of DHC and HPA, it was possible to track progress or degradation of the analyzed areas over time and to recognize the efficaciousness/failure of past managements and interventions (e.g., controlled disturbances), providing decision-makers with a thorough understanding for setting up the most suitable mitigation/contrast measures.
Two Practical Methods to Retrieve Aerosol Optical Properties from Coherent Doppler Lidar
Authors: Zhang Yinchao , Zheng Yize , Tan Wangshu , Guo Pan , Xu Qingyue , Chen Su , Lin Ruiqi , Chen Siying , Chen He
Published: June 2022

Complexly distributed aerosol particles have significant impacts on climate and environmental changes. As one of the vital atmospheric power sources, the wind field deeply affects the distribution and transport of aerosol particles. For a more comprehensive investigation of the aerosols flux and transport mechanism, two retrieval methods of aerosol optical properties (backscatter coefficient and extinction coefficient at 1550 nm) from coherent Doppler lidar (CDL) observation are proposed in this paper. The first method utilizes the calculated aerosol backscatter coefficient (532 nm) from Mie-scattering lidar datasets and the iterative Fernald method to retrieve aerosol optical property profiles during joint measurements with CDL and Mie-scattering lidar. After verifying the correctness of the first method compared with AERONET datasets, we proposed the second retrieval method. Using the forward integral Fernald method with near-ground reference aerosol extinction coefficient calculated by atmospheric visibility, aerosol optical properties at 1550 nm could be obtained. Thirty-six-day joint measurements with two lidars were specially designed and conducted to verify the correctness of these retrieval methods. The validation results of these two methods indicate great performances, where the mean relative errors are 0.0272 and 0.1656, and the correlation coefficients are 0.9306 and 0.9197, respectively. In conclusion, the feasibility of these two retrieval methods extends the capability of CDL to detect aerosol optical properties and also provides a possibility to observe the aerosol distribution and transport process comprehensively, which is a great promotion of aerosol transport studies development.
Modeling Artificial Light Exposure after Vegetation Trimming at a Marine Turtle Nesting Beach
Authors: Barrett Mark A. , Nelson Sella Kristen
Published: June 2022

Light pollution caused by poorly directed artificial lighting has increased globally in recent years. Artificial lights visible along marine turtle nesting beaches can disrupt natural brightness cues used by hatchling turtles to orient correctly to the ocean for their offshore migrations. Natural barriers, such as tall dunes and dense vegetation, that block coastal and inland lights from the beach may reduce this disruption. However, coastal areas are often managed toward human values, including the trimming of vegetation to improve ocean views. We used viewshed models to determine how reducing the dune vegetation height (specifically that of seagrape, Cocoloba uvifera) might increase the amount of artificial light from upland buildings that reaches a marine turtle nesting beach in Southeast Florida. We incorporated three data sets (LiDAR data, turtle nest locations, and field surveys of artificial lights) into a geographic information system to create viewsheds of lighting from buildings across 21 vegetation profiles. In 2018, when most seagrape patches had been trimmed to <1.1 m tall, female loggerhead turtles nested in areas with potential for high light exposure based on a cumulative viewshed model. Viewshed models using random (iterative simulations) and nonrandom selections of buildings revealed that untrimmed seagrape heights (mean = 3.1 m) and especially taller vegetation profiles effectively reduced potential lighting exposure from three building heights (upper story, midstory, and ground level). Even the tallest modeled vegetation, however, would fail to block lights from the upper stories of some tall buildings. Results from this study can support management decisions regarding the trimming of beach dune vegetation, any associated changes in the visibility of artificial lighting from the nesting areas, and modifications to existing lighting needed to mitigate light exposure.
Tradeoffs between UAS Spatial Resolution and Accuracy for Deep Learning Semantic Segmentation Applied to Wetland Vegetation Species Mapping
Authors: Saltiel Troy M. , Dennison Philip E. , Campbell Michael J. , Thompson Tom R. , Hambrecht Keith R.
Published: June 2022

Recent advances in image classification of fine spatial resolution imagery from unoccupied aircraft systems (UASs) have allowed for mapping vegetation based on both multispectral reflectance and fine textural details. Convolutional neural network (CNN)-based models can take advantage of the spatial detail present in UAS imagery by implicitly learning shapes and textures associated with classes to produce highly accurate maps. However, the spatial resolution of UAS data is infrequently examined in CNN classification, and there are important tradeoffs between spatial resolution and classification accuracy. To improve the understanding of the relationship between spatial resolution and classification accuracy for a CNN-based model, we captured 7.6 cm imagery with a UAS in a wetland environment containing graminoid (grass-like) plant species and simulated a range of spatial resolutions up to 76.0 cm. We evaluated two methods for the simulation of coarser spatial resolution imagery, averaging before and after orthomosaic stitching, and then trained and applied a U-Net CNN model for each resolution and method. We found untuned overall accuracies exceeding 70% at the finest spatial resolutions, but classification accuracy decreased as spatial resolution coarsened, particularly beyond a 22.8 cm resolution. Coarsening the spatial resolution from 7.6 cm to 22.8 cm could permit a ninefold increase in survey area, with only a moderate reduction in classification accuracy. This study provides insight into the impact of the spatial resolution on deep learning semantic segmentation performance and information that can potentially be useful for optimizing precise UAS-based mapping projects.
Identification and Evaluation of the Polycentric Urban Structure: An Empirical Analysis Based on Multi-Source Big Data Fusion
Authors: Zhou Yuquan , He Xiong , Zhu Yiting
Published: June 2022

Identifying and evaluating polycentric urban spatial structure is essential for understanding and optimizing current urban development. In order to accurately identify the urban centers of the Guangdong–Hong Kong–Macao Greater Bay Area (GBA), this study firstly fused nighttime light data, POI data, and population migration data based on wavelet transform, then identified the polycentric spatial structure of the GBA by carrying out cluster and outlier analysis, and evaluated the level of different urban centers byconducting geographical weighted regression analysis. Using data fusion, we identified 4579.81 km² of the urban poly-center area in the GBA, with an identification accuracy of 93.22%. Although the number and spatial extent of the identified urban poly-centers are consistent with the GBA development plan outline, the poly-center level evaluation results are inconsistent with the development plan, which shows there are great differences in actual development levels among different cities in the GBA. By identifying and grading the polycentric spatial structure of the GBA, this study accurately analyzed the current spatial distribution and could provide policy implications for the GBA’s future development and planning.