bluuebunny/crossref_metadata_2025 huggingface dataset:
INVESTIGATING THE MEDICINES CUSTOMERS’ BEHAVIOR
Authors: Piven О. , Malyj V. , Dorokhova L. , Rohulia О. , Khrenov О.
Published: October 2020

The main goal of this article is the investigation the influence of factors, preferences, particularities of medi-cines consumers’ behavior in pharmacies, as well as creating a simulation of the consumer’s behavior with nasal medications as a primary example. The investigation methods were used in this article: documentary and logic, grouping and market investigation methods, questionnaires, comparing and generalization methods, economic-statistical method. As a result of such market's investigations it was found out, that Ukrainian market of nasal medicines can offer a wide spectrum of medications and can indeed satisfy the consumers’ needs. The analysis of dynamic of the main market's values in 2016 – 2020 years was also conducted. The profile of the average nasal medicines customers was created based on the developed questionnaire and the interviews done inside pharma-cies. The factors of influence on the consumer behavior and consumers’ choices are reviewed in this article. It was shown, that the consumers' behavior and their choices inside pharmacies depend on many different factors. It was proven, that, among the consumer properties of nasal medicines, therapeutic effectiveness, the quality of the prod-uct, its safety and price had made the most influence on pharmacy’s visitors, while they were making their decision to buy the drug, that they were needed. It was demonstrated, that traditional, well known products based on the chemical substances in the form of sprays and drops, are the most popular among customers. It was shown, that most customers (72%) plan their purchase in advance, though considering how many other customers (28%) make spontaneous purchases, it was recommended to take this information into account while planning the shopping room’s infrastructure, the moving flow of customers and the positioning of showcases with nasal medicines inside them. Such investigations made it available to simulate the behaviors, which are specific to nasal medicines cus-tomers, based on their purchase planning, motivation, pricing sensitivity, their thoughts on new products, their inclination towards specific medicines and trademark, the source of advice. The segmentation of consumers of nasal medicines was done according to the behavioral patterns. The simulation of the pharmacy visitors’ behav-iors as they are deciding on whether to buy specific nasal medicines was carried out. A source of advice was cho-sen on the basis of the simulation as a classification feature. Three simulations of nasal medicines consumers’ behavior were distinguished based on the doctor’s advice, pharmacist advice and independent decision. It was proven that to raise the quality of the service and the effectiveness of the pharmacy in general, specialists should know the customer behavior, their preferences towards medicines and understand the motivation behind custom-er’s purchase.

Keywords: customer, behavior, pharmacy, nasal medicines, pharmaceutical service.
ASSET DIVERSIFICATION THROUGH APPLICATION HOARDING INVESTMENTS
Authors: Verbytska V. , Bredikhin V.
Published: October 2020

The current state and tendencies of development of hoarding investment by legal entities and the population of the country are considered in the article. It is especially important that these investments are available not only for legal entities, but also for the population, where there is a clear relationship between changes in the share of savings hoarded by private individuals and fluctuations in uncertainty, and growing investment and hoarding demand are the consequences of the financial crisis. inflation expectations, geopolitical instability and growing needs for diversification. On the basis of economic-theoretical analysis the essence, character of behavior, types and conditions of realization of hoarding investments (TI) in crisis economy are analyzed. The concept of "hoarding investments" has been clarified. The main subjects and objects of hoarding investments are identified. The objects of hoarding investments are bank metals (and coins from them) precious stones, jewelry, art objects and antiques. Available types, modern tendencies, methods and conditions of realization of hoarding investments are investigated. Coins issued by both Ukrainian and foreign banks were found to be numismatically valuable. However, foreign coins entering our market are usually issued in large numbers and, accordingly, have less numismatic value. In the United States, consumption of diamond jewelry is constantly growing due to the combination of domestic market unsaturation with well-established lending mechanisms, Europe is characterized by stagnation in the consumption of diamond jewelry, and for some countries, such as Germany, even a reduction. Hoarding investments in collectibles are specific in nature, due to their complexity, the relatively narrow market for each type of collection, the need for special knowledge and skills for proper investment.

Keywords: hoarding investments, banking institutions, crisis economy, risk diversification, coins, precious stones, collectibles, profitability, interest.
Implementation of OJS Based iJC Media E-Journal System at University of Pramita Indonesia
Authors: Mumen Md. Abdul , Oganda Fitra Putri , Lutfiani Ninda , Handayani Indri
Published: October 2020

The increasing development of information technology in the era of 5.0 can provide information that is informative and very easy to obtain in the form of electronics. But not at Pramita University of Indonesia in managing journals or other scientific works still using conventional or manual methods that cause the main problem that is causing increased costs and time, the data can be separated because the old data is not archived properly and the management of scientific works also does not meet the specified requirements by Ristekdikti with regard to Journal Accreditation which requires that journals be managed online because that will be easier and faster. With the iJC (iLearning Journal Center) can publish journals online, make it easier for users to submit journals, change the management of ejournal to be more distributed and can simplify the process of submitting manuscripts, reviewing, editing, until the publication stage and by using iLearning Journal Center will produce e quality journal. In this study, researchers used several methods, namely the method of observation and study of literature and using Flowcharts.
الحاضنة الاجتماعية وأثرها في العملية السياسية: دراسة دستورية في السياق التاريخي والعامل الحضاري
Authors: mohammed hasan Baidar mohammed , Ali Abdul Rab Muneer , Mochammad Sahid Mualimin
Published: October 2020

هدفت الدراسة إلى مناقشة قضية دستورية تتعلق بالعملية السياسية في التشريع الدستوري الإسلامي، ولذلك فإنه من الملائم دارسة الأوضاع الاجتماعية، والتي تعتبر ميدان التنافس السياسي على مرّ العصور، وعليه فإنه من الجدير في هذه الدراسة التطرق إلى الانعكاسات المؤثرة التي تضفيها الأوضاع الاجتماعية في العملية السياسية خاصة في ظل وجود بعض الثغرات في جانب الوعي الاجتماعي بأهمية العملية السياسية وممارسة الحق الدستوري في العملية السياسية. والمحيط الاجتماعي يمثل الميدان الخصب لأي نشاط سياسي، أو اقتصادي، أو أي نشاط آخر، ولا شك أن الناتج عن هذه الأنشطة السياسية والاقتصادية وغيرها من المجالات التي تعكس ما عليه حقيقة المجتمع الممارس لهذه النشاطات، فالمجتمع القوي في إمكانياته العلمية والمادية والثقافية والتكنلوجية، يكون نتاجه في المشاركة السياسية نتاجاً مناسباً للمستوى الذي هو عليه، والمجتمع الذي يفتقر إلى جانب كبير من الثقافة والمادة، والتطور التكنولوجي يكون نتاج مشاركته السياسية ضعيفة، مما يؤدي إلى تلاعب أصحاب المصالح بقراراته ومصالحه. ومن الأهمية بمكان عند الحكم على حالة معينة سواء كانت سياسية، أو اقتصادية، دراسة جوانبها الاجتماعية بشيء من الاستفاضة والتحقيق، حتى تتكون فكرة أكثر قرباً إلى الواقع المعاش. ومن أهداف هذه الدراسة عرض البنى الاجتماعية في سياقها التاريخي والمعاصر ومدى تأثيرها في العملية السياسية، سلباً وإيجاباً، ثم التطرق إلى أهمية البناء الحضاري والإنساني والعلمي والثقافي للمجتمعات التي تعتبر المؤثر الأساس في أي نشاط سياسي، حتى يمثل المجتمع الحاضن للعملية السياسية رافداً إيجابياً للعملية السياسية، ويظهر أي نشاط سياسي بشكل حضاري راقي. وقد اعتمد الباحثون في هذه الدراسة على المنهج التأصيلي التحليلي، وقد توصل البحث إلى أهمية الحاضنة الاجتماعية كمؤثِّر فعَّال في أي عملية سياسية.
Analysis of RC Deep Beams Considering the Shear Deformations and Bar-concrete Interaction
Authors: Hashemi Seyed Shaker , Sadeghi Kabir , Javidi Saeid , Malakouti Mahmoud
Published: October 2020

In this paper, reinforced concrete (RC) deep beams (DBs) have been analyzed numerically and a new approach is proposed to the nonlinear numerical modeling of such structural members. The effect of shear deformations and the interaction between reinforcing steel bar and concrete are considered in modeling and analysis. In order to consider the effect of shear deformations, the Timoshenko beam theory has been applied to formulate the analysis method. In the modeling, the RC DB is divided into several sub-elements which are composed of concrete and reinforcing steel bars. Individual degrees of freedom have been assigned to each reinforcing steel bar. Thus, each reinforcing steel bar is able to slip relative to its surrounding concrete and the bond effect is simulated by nonlinear springs. To consider the interaction between reinforcing steel bar and concrete, the concrete segment acts as a beam element, and each reinforcing steel bar acts as a truss element. The reliability of this method has been confirmed by comparing the obtained results from the numerical analysis and the results of the experimental pushover test.
Peace committees, platforms and the political ordering of society: Doing justice in the Federation of Northern and Eastern Syria (NES)
Authors: Knapp Michael , Jongerden Joost
Published: October 2020

Conflict mediation has become an important feature of the justice system of the autonomous self-administration in Rojava and north and east Syria. This conflict mediation takes place mainly through peace committees and platforms. Based on fieldwork in the region, this study addresses the question of how the peace committees and platforms provide justice and what this form of justice provision says about the model of self-administration. A main conclusion we draw is that the primary function of the peace committees and platforms is to institutionalise the new government model and give an ideological direction for the idea of a “good society”.
Abstract in Kurmanji
Komîte û platformên aştiyê û verastkirina siyasî ya civakê: Pêkanîna edaletê li Federasyona Bakur û Rojhilatê Sûriyeyê (BRS)
Navbeynkariya pevçûnê bûye taybetmendiyeke girîng a sîstema edaletê ya xwe-rêveberiya otonom a li Rojava û bakur-rojhilatê Sûriyeyê. Ev navbeynkariya pevçûnan bi awayê sereke bi rêya komîte û platformên aştiyê pêk tê. Li ser bingeha xebata sehayî ya li herêmê, ev xebat berê mirov dide pirsa çawa ev komîte û platformên aştiyê edaletê temîn dikin û ev forma pêşkêşiya edaletê di derbarê modela xwe-rêvebirinê de çi dibêje. Encama bingehîn ku em binxêz dikin ev e ku fonksiyona sereke ya komîte û platformên aştiyê modela nû ya rêvebirinê bi sazî dikin û rêyeke îdeolojîk ji bo fikra “civaka baş” nîşan didin.
Abstract in Sorani
Komîtekanî aştî, platform û rêkxistinî syasî komellge: Encamdanî dadperwerî le fîdrasyonî bakûr û rojhellatî sûrya (NES)
Nawbijîkirdnî nakokî bote taybetmendîyekî gringî sîstemî dadperwerî le le xoserî otonomî rojava we bakur û rojhellatî surya. Em nawbijî kirdnî nakokîye begşitî lerêgay komîte û platformekanî aştî rûdeden. Leser bnemay karî meydanî le herêmekeda, em twêjîneweye ew pirsyare dewrujênêt ke çon komîtekan û platformekan aştî dabîn deken û ew şêwaze le dabînkirdnî dadperwerî çî derbarey modêlî xoserî dellêt. Derencamî serekî ke ême pêy degeyn eweye karî serekî komîte û platforekanî aştî bedamezraweyî kirdnî modêlêkî nwêy hkumetîye û pêdanî arasteyekî aydyolojîye bo bîrokey “cvakî baş”.
Abstract in Zazaki
Heyetê aştî, platformî û awanîya komelî ya sîyasîye: Federasyonê Sûrîyeya Vakur û Rojhelatî (NES) de sîstemê edaletî
Xoîdareyê otonomî yê Rojawan û vakur û rojhelatê Sûrîye de mabênkarîye û werêardiş bîyê faktorê muhîmî yê sîstemê edaletî. Na mabênkarîya têkewtişan zafêrî pê heyet û platformanê aştî virazîyena. Pê xebata warî ya ê herêmî, no cigêrayîş cewabê persî dano ke nê heyet û platformê aştîye senî edalet pêşkêş kenê û boyna, no tewir hukmê edaletî modelê xoîdarekerdişî de yeno çi mana. Yew netîceyo bingeyên o ke ma vînenîme no yo ke fonksîyono sereke yê heyet û platformanê aştîye dezgehkerdişê modelê hukmatî yê neweyî û fikrê “komelê rindî” rê dayîşê rayîrêkê îdeolojîkî yo.
Review article: Kurds, Zazas and Alevis
Authors: Van Bruinessen Martin
Published: October 2020

This review article discusses recent research about two major religious and linguistic minorities among the Kurds of Turkey and their efforts to define distinct identities. The books reviewed include:
Celia Jenkins, Suavi Aydin & Umit Cetin, eds., Alevism as an Ethno-Religious Identity: Contested Boundaries, Oxon and New York: Routledge, 2018, 130 pp., (ISBN 978-1-138-09631-8).
Erdal Gezik & Ahmet Kerim Gültekin, eds., Kurdish Alevis and the Case of Dersim: Historical and Contemporary Insights, Lanham, MD: Lexington Books, 2019, 172 pp., (ISBN 978-1-4985-7548-5).
Eberhard Werner, Rivers and Mountains: A Historical, Applied Anthropological and Linguistical Study of the Zaza People of Turkey Including an Introduction to Applied Cultural Anthropology, Nürnberg: VTR Publications, 2017, 549 pp., (ISBN 978-3-95776-065-4).
Editorial
Authors: Schäfers Marlene
Published: October 2020

In his editorial for last year’s May issue of Kurdish Studies, founding editor Prof. Ibrahim Sirkeci noted how navigating the “highly contested and politically charged field” of Kurdish studies required impartiality and a commitment to academic integrity on the part of the journal. Yet our professed impartiality does not mean that we stand aloof from social and political developments, nor that our editorial work is not guided by a number of moral, political and academic principles. As the leading scholarly journal in the field of Kurdish studies, we are aware of the role that the journal plays in creating structures of visibility, shaping knowledge production and, not least, influencing careers. We therefore believe that the recent discussion on male violence and sexual harassment in Kurdish studies, which was initiated by the publication of an anonymous letter via the Kurdish Studies Network, is of direct significance to the journal. It has initiated a discussion that was, in many ways, long overdue, both for the field as a whole and for our journal.
An outbreak of multidrug-resistant Salmonella Kentucky infection in long-nosed fur seals
Authors: Blyde DJ , March D , Howard P , Sintchenko V , Rousselet E , Atkin C
Published: October 2020

An outbreak of salmonellosis occurred in a group of 7 long-nosed fur seals Arctocephalus forsteri undergoing rehabilitation after being found injured and malnourished on beaches along the northern New South Wales and southern Queensland coasts of Australia. Three of the 7 individuals developed clinical disease and died within 3 d. Clinical signs included profuse diarrhea, vomiting, depression, and lethargy. Salmonella enterica subsp. enterica serovar Kentucky (S. Kentucky) was cultured from 2 of the 3 deceased animals. The other 4 animals showed similar signs and recovered following treatment. S. Kentucky (antigenic formula 8,20:i:z6) was isolated from the survivors and tissues recovered from post-mortem samples of deceased animals. The bacterium was susceptible to cephalothin and sulfamethoxazole/trimethoprim and resistant to amoxicillin-clavulanate, ampicillin/amoxicillin, tetracycline, and enrofloxacin. This organism has the potential to cause disease in aquatic wildlife, as well as posing a zoonotic threat to people who utilise the aquatic environment.
THE MENTAL HEALTH CARE MODEL TO SUPPORT THE COMMUNITY DURING THE COVID-19 PANDEMIC IN THAILAND
Authors: Ketphan Onpicha , Juthamanee Siripattra , Racal Sarah Jane , Bunpitaksakun Dussanee
Published: October 2020

The COVID-19 pandemic has caused people worldwide, such as in Thailand, to be frightened of being infected from the coronavirus. Exposure to media - including unreliable news sources - trigger people's stress and anxiety. This leads to increased mental health problems and psychiatric disorders in the population, resulting in higher suicide rates. Furthermore, this also affects medical and public health care staff working until emotional exhaustion and physical health deterioration. The ongoing fight against the outbreak of the COVID-19 virus increases the likelihood of pressure, stress, and anxiety. Therefore, a mental health care model for the people of Thailand is necessary. With the appropriate format for people to receive correct information, people will be more likely to accept changes, think logically and positively, not be discouraged, and be ready to improve themselves and their mental health.
Anatomical-Physiological and Biophysical Principles of Brain Functioning in Waking and Sleep
Authors: Volobuev A. , Pyatin V. , Romanchuk N. , Bulgakova S. , Romanov D.
Published: October 2020

The analysis of some features of a brain work under condition of representation of a neocortex as set of cyclic neural circuits — cells of memory, has allowed understand many effects of a brain work. In particular the essence of a cognitive, creative activity, possible pathological conditions of memory: Alzheimer’s disease, etc. is investigated. Consideration of some other structures of a brain: hippocampus, entorhinal cortex has allowed understand a phenomenon of dream, its modes, essence of dreams, functionalities of a brain during dream, etc. Mathematical modelling of the electroencephalogram rhythms carried out during phases of slow dream. Interrelation of the rhythm’s frequency of slow dream with distance between the next cyclic neural circuits is shown.
THE ISSUE OF LS-OPTIMIZATION SATELLITE GEODETIC NETWORKS IN THE TERRESTRIAL COORDINATE SYSTEM
Authors: Padve Vladimir A. , Kosarev Nikolay S.
Published: October 2020

The issue of processing GNSS measurements performed to add a new item into a "hard" network is discussed. Two variants of this add: «beam» and «network» are compared. A fragment of the satellite network, which includes five "hard" points of the main network and one defined, acted as the object on which the computational experiment was carried out, testing the theory of this question. The processing of observational materials is implemented in to Excel electronic computational table using an algorithm synthesized version of the parametric version of LS-optimization of spatial data. The «insert» coordinates obtained as a result of this processing and their average square errors were identical for both variants, which is what follows from the theory of LS-optimization of measurement results taking into account of the errors of the coordinates of «hard» points.
METHODS OF DUST CONTROL ON OPEN-CAST MINE
Authors: Pisarev Viktor S. , Basargin Andrei A.
Published: October 2020

The practice of dust control on coal mines and technological roads both in Russia and abroad shows that reducing dust content, to the maximum permissible concentrations is a very difficult engineering task. To combat dust in open pit mines, various methods and techniques are used. The study of progressive dust control agents will allow normalizing sanitary and hygienic conditions at mining enterprises, and reducing the level of occupational diseases of miners. The article deals with the types of dust and the fact that a large amount of dust accompanies the processes of extraction and transportation of coal from the open-cast to the concentration plant. The experience of dust control at the enterprises of Joint Stock Company Siberian Anthracite is given.
RESULTS OF MINE SURVEYING AND GEODESIC OBSERVATIONS ON DEFORMATIONS OF APSAT COAL CUTTING BOARDS
Authors: Stupin Vladimir P. , Beliaev Evgenii N. , Karpova Irina A.
Published: October 2020

The methodology and organization of surveying and geodesic monitoring of the sides of a coal mine using laser scanning are described. The results of observations are presented. Conclusions about the stability of the sides of the coal mine are made and the possibilities of the methods used are evaluated.
INNOVATIVE CODES OF THE LANGUAGE OF STAGE ART OF EUGENIY BAGRATIONOVICH VAKHTANGOV ON THE MATERIAL OF PERFORMANCES OF THE BEGINNING OF THE XX CENTURY
Authors: Fedorov Alexey A.
Published: October 2020

The creative work presented at the International intramural and extramural festival competition of youth theater companies - “Prometheus of a Rukh” - “Spirit of Prometheus” became a threshold of the present article, devoted to the Year of theater in Russia and to the 100 anniversary from the date of the birth of the National poet of Bashkortostan, the playwright Mustaya Karim, and gained the diploma of the Winner of the First degree. In the present work, as part of the creative path, the practice and theorist of the field of art of Eugeniy Bagrationovich Vakhtangov, the language of fantastic realism as the language of artistic theatre is studied. The starting point of the research is to establish the elements of the language of conditional theater based on scenographic, acting and directing decisions in Vakhtangov's performances. For this purpose, the author makes a retrospective appeal to the director's performances. In the analysis of the chosen performances, the artistic deals with innovative instrumentation of Vakhtangov’s theatre language, which formed the director 's own understanding of the artistic style of the theatre as fantastic realism. Elements of the theatrical language of the most significant performances are considered: “Peace Holiday”, “Cricket on an oven”, “Eric XIV”, “Gadibuk” and “Princess Turandot”. Based on the sources in which the performances are described, the Vakhtangov theatre language (style) is analyzed. As a result, descriptive definitions of the concepts of Vakhtangov style and fantastic realism are given. Interfacing analysis with the basic provisions of the concept of fantastic realism, elements of the language of conditional theatre are combined into a single table, which is one of the main results of the work. The work is written within the framework of the project XI.170.1.2. (0325-2017-0013), № АААА-А17-117022250128-5.
MAINTENANCE AND DEVELOPMENT OF A MATERIAL BASE AS A KEY ORGANIZATIONAL MOMENT OF INSTITUTIONALIZATION PROCESS
Authors: Stukalo Leonid M. , Stukalo Dmitriy L.
Published: October 2020

The article discusses the existing state of the material base of the Department of Physical Education of SSUGT and the regulatory requirements for material bases in higher educational institutions of the country.
URBAN ARCHITECTURE AND CITIZENS’ SOCIAL PRACTICES: INFLUENCE AND INTERDEPENDENCE
Authors: Chaplya Tatiana V.
Published: October 2020

The article is devoted to the history of city’s image formation and consolidation of communicative practices, using the design of a city center as a core of official life; square as a center of public communication and a modern supermarket as a city in miniature. It is concluded that in the course of history two processes interact: the differentiation of the urban population and the transformation of urban space.
Trusted Decision-Making: Data Governance for Creating Trust in Data Science Decision Outcomes
Authors: Brous Paul , Janssen Marijn
Published: October 2020

Organizations are increasingly introducing data science initiatives to support decision-making. However, the decision outcomes of data science initiatives are not always used or adopted by decision-makers, often due to uncertainty about the quality of data input. It is, therefore, not surprising that organizations are increasingly turning to data governance as a means to improve the acceptance of data science decision outcomes. In this paper, propositions will be developed to understand the role of data governance in creating trust in data science decision outcomes. Two explanatory case studies in the asset management domain are analyzed to derive boundary conditions. The first case study is a data science project designed to improve the efficiency of road management through predictive maintenance, and the second case study is a data science project designed to detect fraudulent usage of electricity in medium and low voltage electrical grids without infringing privacy regulations. The duality of technology is used as our theoretical lens to understand the interactions between the organization, decision-makers, and technology. The results show that data science decision outcomes are more likely to be accepted if the organization has an established data governance capability. Data governance is also needed to ensure that organizational conditions of data science are met, and that incurred organizational changes are managed efficiently. These results imply that a mature data governance capability is required before sufficient trust can be placed in data science decision outcomes for decision-making.
Integrated Management of Weeds in Direct-Seeded Rice in Cambodia
Authors: Martin Robert , Som Bunna , Janiya Joel , Rien Ratha , Yous Sophea , Chhun Sokunroth , Korn Chariya
Published: October 2020

The objective of this work was to determine the value of improved establishment methods and herbicide applications as alternatives to high seeding rates to improve weed suppression in rice. Field experiments were carried out in 2010 and 2011 to determine optimal seeding rates and seeding methods with and without weed competition in wet-seeded rice. Under wet seeding conditions, drum seeding at 80 kg ha−1 was the most profitable treatment for both weed-free and unweeded rice. Although pre-emergence herbicides are beginning to be adopted in wet-seeded rice, they are seldom used in dry direct-seeded rice in Cambodia. Experiments were carried out in 2018 and 2019 to test crop tolerance and the efficacy of butachlor, oxadiazon, pendimethalin and pretilachlor applied post-sowing and pre-emergence to dry direct-seeded rice. Oxadiazon and butachlor, with the option for a post-emergence herbicide, provided effective weed control and a high grain yield in dry direct-seeded rice. Pretilachlor did not effectively control weeds under dry seeding conditions. Although pendimethalin exhibited good weed control, crop damage was a risk in poorly prepared seedbeds which typify Cambodian rice systems. With an effective integrated weed management strategy, it might be possible to safely reduce seeding rates below 80 kg ha−1 using drum or drill seeding machines.
From Dimness to Glossiness—Characteristics of the Spring Rapeseed Mutant Form without Glaucous Bloom (Brassica napus L.)
Authors: Shirokova Anna V. , Volovik Valentina T. , Zagoskina Natalia V. , Zaitsev Georgiy P. , Khudyakova Hatima K. , Korovina Larisa M. , Krutius Oleg N. , Nikolaeva Tatiana N. , Simonova Olga B. , Alekseev Andrey A. , Baranova Ekaterina N.
Published: October 2020

As a result of the treatment of “Vikros” spring canola with the chemical mutagen ethyl methanesulfonate (EMS), a high-protein mutant form without glaucous bloom (wax bloom) on leaves, shoots, and siliques was isolated. Segregation into glossy and glaucous forms was always observed in the progeny of glossy plants from self-pollination, and the proportion of glaucous plants could reach up to 25%. The progeny of glaucous plants were homogeneous and did not segregate. If during the period of seed germination and seedling development the soil did not dry out and remained moist, and the average daily temperature did not exceed 16 °C, then the amount of glossy plants could reach 99%. Glossy plants possessed qualities valuable for breeding forage varieties, such as the increased content of protein in seeds (more than 30%), and change phenol metabolism, чтo прoявляется a reduced amount of lignin and sinapine in comparison with the original cultivar. In addition, plants without wax coating showed weakened shoot growth, decreased pollen fertility and seed production, and reduced lignin content in the shoots. Glossy mutants are of interest for the obtaining of fodder low-sinapine and low-lignin varieties of spring rapeseed.
Rootstock Influence on Growth and Mineral Content of Citrus limon and Citrus sinensis cv. Valencia Inoculated with Candidatus Liberibacter Asiaticus
Authors: Sáenz-Pérez Criseida Alhelí , Osorio-Hernández Eduardo , Estrada-Drouaillet Benigno , Castro-Nava Sergio , Delgado-Martínez Rafael , López-Badillo Claudia Magdalena , Rodríguez-Herrera Raúl
Published: October 2020

Huanglongbing (HLB) reduces the growth and development of citrus and induces changes in secondary metabolites such as flavonoids, limonoids, and polyamines. Likewise, infected plants have a deficient absorption of nutrients such as zinc, potassium, manganese, and copper. Therefore, the objective of this study was to evaluate the influence of different rootstocks on morphology and mineral changes of Citrus limon and Citrus sinensis cv. Valencia plants inoculated with Candidatus Liberibacter asiaticus. In a greenhouse of the Experimental Station-Autonomous University of Tamaulipas, the Candidatus Liberibacter asiaticus bacteria were inoculated to Citrus limon plants (growing on Citrus volkameriana, Citrus macrophylla, and Citrus aurantium rootstocks) and Citrus sinensis cv. Valencia (growing on Citrus volkameriana and Citrus aurantium rootstocks). The experiment was established under a completely randomized design with 45 graft/rootstock repetitions. In each graft/rootstock combination, the plant height and stem diameter were determined using a tape measurer and a Vernier, respectively. In addition, the nutrient content of foliar samples was determined by an X-ray fluorescence spectrometer. In both citrus species, the C. aurantium rootstock promoted a higher concentration of the bacteria. On the other hand, the rootstock that showed the best agronomical results after inoculation with the bacteria was C. volkameriana, presenting the least variation in mineral content and conferring greater plant height (15%) and stem diameter (23%). In contrast, the presence of Ca. Liberibacter asiaticus decreased S content and increased Cu concentration in C. lemon plants. Similarly, plants infected with C. sinensis presented higher Fe content. Finally, in both species, no significant differences were observed for Mn, P, and Zn concentration.
Pigments on Roman Wall Painting and Stucco Fragments from the Monte d’Oro Area (Rome): A Multi-Technique Approach
Authors: Guglielmi Vittoria , Comite Valeria , Andreoli Martina , Demartin Francesco , Lombardi Chiara Andrea , Fermo Paola
Published: October 2020

This work concerns the characterisation of a set of wall painting and stucco fragments collected during a rescue excavation carried out in 2013 by the Soprintendenza Archeologica in the Monte d’Oro area (Rome). Due to the contextless archaeological situation, analyses were performed to obtain more information about the collected materials. A multi-analytical approach has been applied including spectroscopic (FTIR, Raman and visible reflectance analyses) and elemental analysis (SEM-EDS) techniques. The chromatic palette has been in this way disclosed evidencing the use of pigments such as cinnabar, Egyptian blue, red and yellow ochre and green earth, but also the simultaneous use of them. The presence of a decoration achieved by using a gold leaf has been highlighted also, indicating the preciousness of the decorations. The convenience and advantages linked to the use of portable instrumentation have been also evidenced.
Stochastic Recognition of Physical Activity and Healthcare Using Tri-Axial Inertial Wearable Sensors
Authors: Jalal Ahmad , Batool Mouazma , Kim Kibum
Published: October 2020

The classification of human activity is becoming one of the most important areas of human health monitoring and physical fitness. With the use of physical activity recognition applications, people suffering from various diseases can be efficiently monitored and medical treatment can be administered in a timely fashion. These applications could improve remote services for health care monitoring and delivery. However, the fixed health monitoring devices provided in hospitals limits the subjects’ movement. In particular, our work reports on wearable sensors that provide remote monitoring that periodically checks human health through different postures and activities to give people timely and effective treatment. In this paper, we propose a novel human activity recognition (HAR) system with multiple combined features to monitor human physical movements from continuous sequences via tri-axial inertial sensors. The proposed HAR system filters 1D signals using a notch filter that examines the lower/upper cutoff frequencies to calculate the optimal wearable sensor data. Then, it calculates multiple combined features, i.e., statistical features, Mel Frequency Cepstral Coefficients, and Gaussian Mixture Model features. For the classification and recognition engine, a Decision Tree classifier optimized by the Binary Grey Wolf Optimization algorithm is proposed. The proposed system is applied and tested on three challenging benchmark datasets to assess the feasibility of the model. The experimental results show that our proposed system attained an exceptional level of performance compared to conventional solutions. We achieved accuracy rates of 88.25%, 93.95%, and 96.83% over MOTIONSENSE, MHEALTH, and the proposed self-annotated IM-AccGyro human-machine dataset, respectively.
Gliclazide: Biopharmaceutics Characteristics to Discuss the Biowaiver of Immediate and Extended Release Tablets
Authors: Mapa Bruna de Carvalho , Araújo Lorena Ulhôa , Silva-Barcellos Neila Márcia , Caldeira Tamires Guedes , Souza Jacqueline
Published: October 2020

The lists of essential medicines of the World Health Organization (WHO) and Brazil include gliclazide as an alternative to the oral antidiabetic drug of first choice, metformin, in the treatment of type 2 diabetes mellitus because of its pharmacokinetic profile and few side effects. Thus, it is also considered by WHO and the International Pharmaceutical Federation (FIP) as a drug candidate to biowaiver, which is the evaluation of how favorable the biopharmaceutics characteristics are in order to obtain waiver from the relative bioavailability/bioequivalence (RB/BE) studies to register new medicines. This paper presents a review about the solubility, permeability and dissolution of gliclazide. A critical analysis of the information allowed to identify gliclazide as a Biopharmaceutics Classification System (BCS) Class II drug. Therefore, new drugs in immediate release dosage forms will not be eligible for biowaiver. Regarding the extended release dosage forms, besides the limited solubility, no information on the comparative dissolution profile was found, which would be necessary to analyze a possible biowaiver for a smaller dosage. It can be concluded that the registration of new medicines containing gliclazide must undergo RB/BE studies, since there is not enough evidence to recommend the replacement and waiver of such studies for immediate and extended release formulations.
Secure Delivery Scheme of Common Data Model for Decentralized Cloud Platforms
Authors: Cho Jae Hyuk , Kang Yunhee , Park Young B.
Published: October 2020

The Common Data Model (CDM) is being used to deal with problems caused by the various electronic medical record structures in the distributed hospital information system. The concept of CDM is emerging as a collaborative method of exchanging data from each hospital in the same format and conducting various clinical studies based on shared data. The baseline of a CDM system is centralized with an infrastructure typically controlled by a single entity with full authority. The characteristics of this centralized system can pose serious security issues. Therefore, the proposed SC-CDM system is designed as a platform for distributed ledger and provides data with a high level of confidentiality, security, and scalability. This framework provides a reference model that supports multiple channels, using secure CDM as an encryption method. The data confidentiality of CDM is guaranteed by asymmetric and symmetric protocols. Delivering CDM is protected by a symmetric key signed by the CDM creator and maintains lightweight distributed ledger transactions on Inter Planetary File System (IPFS), which acts as a file share. To deliver an encrypted CDM on the SC-CDM platform, the CDM is encrypted with a block cipher by a random symmetric key and Initialization Vector (IV). The symmetric key protocol is used for the fast encryption of large-capacity data. The SC-CDM is implemented the repository with IPFS for storing the encrypted CDM, in which symmetric key, two hash values, and IV are shared through blockchain. Data confidentiality of SC-CDM is guaranteed by only registered users accessing the data. In conclusion, the SC-CDM is the first approach to demultiplexing with the data confidentiality proof based on asymmetric key cryptography. We analyze and verify the security of SC-CDM by comparing qualitative factors and performance with existing CDM. Moreover, we adopt a byte-level processing method with encryption to ensure efficiency while handling a large CDM.
A Prospective Randomized Clinical Trial to Evaluate the Slot Size on Pain and Oral Health-Related Quality of Life (OHRQoL) in Orthodontics during the First Month of Treatment with Conventional and Low-Friction Brackets
Authors: Curto Adrian , Albaladejo Alberto , Montero Javier , Alvarado-Lorenzo Mario , Garcovich Daniele , Alvarado-Lorenzo Alfonso
Published: October 2020

The aim of this research project was to analyze the influence of slot size and low-friction on pain and the oral health-related quality of life (OHRQoL) of subjects receiving fixed appliances. A group of 120 patients (61 male, 59 female) were chosen for this randomized clinical trial. Participants were classified into four groups (30 patients in each). We compared conventional (C group) and low-friction (LF group) brackets and 0.018″ and 0.022″ slots. Pain was assessed at 4 (T0), 8 (T1), and 24 (T2) hours, and 2 (T3), 3 (T4), 4 (T5), 5 (T6), 6 (T7), and 7 (T8) days after the start of treatment by using the visual analogue scale (VAS). OHRQoL was assessed at 1 month using the Oral Health Impact Profile (OHIP-14). Data was analyzed using the analysis of variance (ANOVA) test with post-hoc Bonferroni correction. For pain on the visual analogue scale, statistically significant differences (p < 0.05) were found for T0 and T3. For OHRQoL, statistically significant differences (p < 0.01) were found in the domains of physical pain, psychological discomfort, psychological disability, and overall OHIP. The group with 0.022″ low-friction brackets showed a lower pain score and less impact on OHRQoL. The type of bracket system used and bracket slot size influenced patients’ perceptions of pain and their OHRQoL.
Use of a Mixed Cationic-Reverse Phase Column for Analyzing Small Highly Polar Metabolic Markers in Biological Fluids for Multiclass LC-HRMS Method
Authors: Roverso Marco , Di Gangi Iole Maria , Favaro Gabriella , Pastore Paolo , Bogialli Sara
Published: October 2020

The determination of small highly polar metabolites at low concentrations is challenging when reverse-phase (RP) chromatography is used for multiclass analysis. A mixed cationic-RP column coupled to high-resolution tandem MS (HR-MS/MS) was tested for highly polar compounds in biological fluids, i.e., trimethylamine N-oxide (TMAO) and the isobaric molecules beta-methylamino-L-alanine (BMAA) and 2,4-diaminobutyric acid (DAB). The efficient retention and separation of the above compounds were obtained with common and MS-friendly RP conditions, reaching high selectivity and sensitivity. The method was firstly assessed in plasma and urine, showing good linearity in the range 50–1000 µg/L and 500–10,000 µg/L for TMAO and both BMAA and DAB, respectively. Excellent precision (RDS < 3%) and good accuracies (71–85%) were observed except for BMAA in plasma, whose experimental conditions should be specifically optimized. Preliminary tests performed on compounds with biological relevance and a wider range of polarities proved the effectiveness of this chromatographic solution, allowing the simultaneous analysis of a larger panel of metabolites, from very small and polar compounds, like trimethylamine, to quite lipophilic molecules, such as corticosterone. The proposed LC-HRMS protocol is an excellent alternative to hydrophilic interaction liquid chromatography and ion-pairing RP chromatography, thus providing another friendly analytical tool for metabolomics.
Design and Fabrication of Complex-Shaped Ceramic Bone Implants via 3D Printing Based on Laser Stereolithography
Authors: Safonov Alexander , Maltsev Evgenii , Chugunov Svyatoslav , Tikhonov Andrey , Konev Stepan , Evlashin Stanislav , Popov Dmitry , Pasko Alexander , Akhatov Iskander
Published: October 2020

3D printing allows the fabrication of ceramic implants, making a personalized approach to patients’ treatment a reality. In this work, we have tested the applicability of the Function Representation (FRep) method for geometric simulation of implants with complex cellular microstructure. For this study, we have built several parametric 3D models of 4 mm diameter cylindrical bone implant specimens of four different types of cellular structure. The 9.5 mm long implants are designed to fill hole defects in the trabecular bone. Specimens of designed ceramic implants were fabricated at a Ceramaker 900 stereolithographic 3D printer, using a commercial 3D Mix alumina (Al2O3) ceramic paste. Then, a single-axis compression test was performed on fabricated specimens. According to the test results, the maximum load for tested specimens constituted from 93.0 to 817.5 N, depending on the size of the unit cell and the thickness of the ribs. This demonstrates the possibility of fabricating implants for a wide range of loads, making the choice of the right structure for each patient much easier.
Improvement of Diagnostic Parameters of a Rolling Wheel with Flat Spot and Experimental Test on Lithuanian Railways
Authors: Kukėnas Vladas , Kharitonov Boris , Levinzon Mikhail , Jasevičius Raimondas
Published: October 2020

The JSC (Joint-Stock Company) “Railway Products Conformity Assessment Center”, under a contract with JSC “Lithuanian Railways”, carried out a rolling stock geometry and rolling surface defect risk assessment study which analyzed the principles and algorithm of the ATLAS-LG system used by JSC “Lithuanian Railways” and the system’s advantages and similarities with other systems used for rolling surface defect prediction worldwide. According to the results of this study, JSC “Voestalpine VAE Legetecha” made changes to the algorithms of its ATLAS-LG computing system and changed the parameter used to determine the damage to wheelsets. The goal of this work was to review the automatic systems of rolling stock used to evaluate the state of the rolling stock, compare the criteria for culling, describe the methodology for setting a new parameter for detecting wheel damage Pderivative instead of the previous parameter Kdm, and upgrade operational algorithms of ATLAS. This paper describes the algorithm and methodology for setting a new parameter, evaluating the construction of rolling stock and movement speed. To develop a replacement algorithm for the ATLAS-LG system, a new parameter verification methodology using the inverse Laplace transform for the mathematical model was used.
Nonlinear Dynamics of a Cavity Containing a Two-Mode Coherent Field Interacting with Two-Level Atomic Systems
Authors: Khalil E. M. , M. Alshehri Hashim , Mohamed A.-B. A. , Abdel-Khalek S. , Obada A.-S. F.
Published: October 2020

This study analytically explored two coupled two-level atomic systems (TLAS) as two qubits interacting with two modes of an electromagnetic field (EMF) cavity via two-photon transitions in the presence of dipole–dipole interactions between the atoms and intrinsic damping. Using special unitary su(1,1) Lie algebra, the general solution of an intrinsic noise model is obtained when an EMF is initially in a generalized coherent state. We investigated the population inversion of two TLAS and the generated quantum coherence of some partitions (including the EMF, two TLAS, and TLAS–EMF). It is possible to generate quantum coherence (mixedness and entanglement) from the initial pure state. The robustness of the quantum coherence produced and the sudden appearance and disappearance of coherence depended not only on dipole–dipole coupling but also on the intrinsic noise rate. The growth of mixedness and entanglement may be enhanced by increasing dipole–dipole coupling, leading to more robustness against intrinsic noise.
A Machine Learning Framework for Assessing Seismic Hazard Safety of Reinforced Concrete Buildings
Authors: Harirchian Ehsan , Kumari Vandana , Jadhav Kirti , Raj Das Rohan , Rasulzade Shahla , Lahmer Tom
Published: October 2020

Although averting a seismic disturbance and its physical, social, and economic disruption is practically impossible, using the advancements in computational science and numerical modeling shall equip humanity to predict its severity, understand the outcomes, and equip for post-disaster management. Many buildings exist amidst the developed metropolitan areas, which are senile and still in service. These buildings were also designed before establishing national seismic codes or without the introduction of construction regulations. In that case, risk reduction is significant for developing alternatives and designing suitable models to enhance the existing structure’s performance. Such models will be able to classify risks and casualties related to possible earthquakes through emergency preparation. Thus, it is crucial to recognize structures that are susceptible to earthquake vibrations and need to be prioritized for retrofitting. However, each building’s behavior under seismic actions cannot be studied through performing structural analysis, as it might be unrealistic because of the rigorous computations, long period, and substantial expenditure. Therefore, it calls for a simple, reliable, and accurate process known as Rapid Visual Screening (RVS), which serves as a primary screening platform, including an optimum number of seismic parameters and predetermined performance damage conditions for structures. In this study, the damage classification technique was studied, and the efficacy of the Machine Learning (ML) method in damage prediction via a Support Vector Machine (SVM) model was explored. The ML model is trained and tested separately on damage data from four different earthquakes, namely Ecuador, Haiti, Nepal, and South Korea. Each dataset consists of varying numbers of input data and eight performance modifiers. Based on the study and the results, the ML model using SVM classifies the given input data into the belonging classes and accomplishes the performance on hazard safety evaluation of buildings.