bluuebunny/crossref_metadata_2025 huggingface dataset:
¿Puede la Fasciola hepatica modular la gravedad del COVID–19?
Authors: Cabrera–González Marco , Quilcate–Pairazamán Carlos , Cueva–Rodríguez Medali
Published: March 2024

Perú es considerada una zona hiperendémica de fasciolosis con una prevalencia entre 6,7 a 47,7% (promedio 24,4%) en humanos. En esta zona, la eficacia del Triclabendazol en bovinos es solo del 25,2%, por ello la presencia de cepas resistentes está ampliamente distribuida. El problema se acentúa por ser una enfermedad zoonótica. Además, el Triclabendazol es el único fármaco eficaz contra las distintas formas del parásito. Las catepsinas L y B están involucradas en la migración, nutrición, reproducción y evasión de la respuesta inmune y supervivencia de Fasciola hepatica. Al analizar el proceso en el que el virus SARS–CoV–2 ingresa a la célula, se requiere la presencia de proteasa de serina celular de transmembrana 2 (TMPRSS2) y catepsina L/B (CTSL); donde TMPRSS2 activa la glicoproteína S viral para fusionar la célula con la membrana viral, mientras que la glicoproteína S viral es activada por CTSL, lo que permite la fusión de la membrana endosómica y viral, que el virus infecte a la célula hospedadora es preocupante para estimar el posible efecto que podría generar en poblaciones infectadas con F. hepatica debido a que se necesita una coinfección existente, como resultado del aumento sistémico de las catepsinas L/B secretadas por este parásito y la supervivencia dentro del hospedador definitivo, posiblemente estas poblaciones se vuelvan más susceptibles a la infección viral por coinfección con el parásito; haciendo un llamado a la comunidad científica para identificar alternativas de control de parásitos y no tener un problema asociado a corto plazo.
Chemical Approach to Offshore Wind Turbines: Coating Systems, Environmental Impacts, And Sustainable Development
Authors: Çelik Gül Gülşah , Gül Metin
Published: March 2024

The deployment of offshore wind turbines (WTs) is gaining momentum worldwide, offering significant potential for clean energy generation. However, the maintenance and longevity of offshore WT structures present complex challenges, particularly concerning corrosion protection coatings and their environmental impacts. This paper discusses the key design criteria, protective mechanisms, and application methods of coating systems for offshore WTs, emphasizing the need for durable solutions to withstand harsh marine conditions. Additionally, the study examines the chemical emissions originating from offshore wind farms, including corrosion products and plastics, and their potential ecological impacts. While there is a lack of comprehensive scientific studies on the environmental effects of deepwater, floating offshore wind farms, this paper aims to shed light on these issues and their implications for marine ecosystems and human health. By synthesizing existing literature on analogous situations, the discussion provides insights into the environmental footprints of offshore wind power and underscores the importance of prudent decision-making in advancing future offshore wind projects.
Siddhartha's Quest for Ultimate Truth: A Philosophical Analysis with Brahma Sutra Insights
Authors: Nikita Tewari  , Dr. Deepika Pant
Published: March 2024

The present study is an inquiry into the philosophical and spiritual implications of Brahman that are inextricably linked to the thematic concerns illustrated in Hesse’s novella Siddhartha. As Siddhartha embarks on his journey toward enlightenment, he undergoes a profound transformation in his perception of the world. He comes to the realization that the world is interconnected, unified, and subject to cyclical patterns. This newfound awareness becomes pivotal in Siddhartha’s quest for the ultimate truth, finally culminating in his identification with the supreme consciousness. In light of this, the paper aims to present an argument highlighting how Siddhartha's experiences and motivations are influenced by the philosophical concept of Brahman, as elucidated in the Brahma Sutra.
Student and Staff Experiences of Online Learning: Lessons from Covid-19 in an Australian Law School
Authors: Blake Meredith , Ricciardo Aidan , Clare Joseph , McGaughey Fiona , Skead Natalie , McCutcheon Jani
Published: March 2024

This article explores the experiences of UWA Law School students and staff of the fully online learning and teaching environment introduced in response to the COVID-19 pandemic. It commences with a literature review which identifies several key themes in relation to the emergency remote teaching (ERT) response effected by universities across the globe. It then sets out the results of surveys of Juris Doctor students and teaching staff on their experiences of pre-COVID education in semester 2 of 2019, during the period of ERT in semester one 2020, and in semester 2 of 2020 when classes and assessment had resumed largely face-to-face. The overarching aim of this study was to gather information and data to help guide and inform the development of future learning and teaching strategy at UWA Law School.

The survey responses indicate a clear correlation between rates of student and staff satisfaction and the nature of the learning and teaching environment. The authors draw on the theory of connectivism in their analysis of the survey, concluding that the key message is that there is an ongoing need for flexibility and adaptability in the learning and teaching of law, particularly with assessments.
Factors influencing self-care management in adult hemodialysis patients: An integrative review
Authors: Yasin Fadumo , Khraim Fadi , Santos Mark , Forgrave Daniel , Hamad Abdullah
Published: March 2024

Background: End-stage renal disease (ESRD) poses a significant health challenge, with hemodialysis (HD) being the most prevalent therapy. Patients undergoing HD must comply with a strict therapeutic regimen, including dietary control, fluid restriction, and medication adherence. Successful disease management and improved outcomes rely on patients’ involvement and participation in their care.

Aim: To identify the factors that hinder or facilitate self-care management (SCM) in HD patients.

Methodology: This review followed Whittemore and Knafl’s integrative review framework. A comprehensive literature search of articles published between 2017 and 2022 was conducted in CINAHL, Medline, and PubMed using the keywords end-stage renal disease, hemodialysis, self-care management, self-care, and self-management. This search yielded 21 suitable articles for review.

Results: SCM is influenced by three main factors: facilitators, barriers, and outcomes. Facilitators of SCM include self-care management interventions, patient knowledge, socio-demographic factors, family support, healthcare professionals, peer support, and psychological factors. Barriers encompass psychological and physical conditions. Outcomes include both physiological and psychological aspects.

Conclusion: Understanding the factors influencing SCM in HD patients is vital for developing reliable and effective self-care strategies and interventions to enhance both physical and psychological outcomes.
Comparison of nut losses and foreign material separation efficiencies of hazelnut harvesting machines under different orchard yield conditions
Authors: Sauk Hüseyin , Beyhan Mehmet Arif
Published: March 2024

In this study, the possibilities of using the prototype manufactured hazelnut harvesting machine with a mechanical efficient harvesting unit and hazelnut harvesting machine with a pneumatic efficient harvesting unit in the mechanical harvesting of hazelnuts grown in flat and near flat land conditions were examined and the nut losses and the efficiency values of separating foreign materials were determined to reveal how these machines affect the hazelnut harvesting system. For this purpose, the trials were carried out under five different orchard yield conditions (71.74, 143.48, 215.23, 286.97, and 358.72 kg ha-1). As a result of the experiments, the nut loss and foreign material removal efficiency obtained by hazelnut harvesting with a hazelnut harvesting machine with a mechanical effective harvesting unit were determined between 34.39-37.92% and 96.91-95.62%, respectively. The nut losses and foreign material removal efficiency values obtained by hazelnut harvesting machine with a pneumatic effective harvesting unit were determined between 6.84-5.07% and 93.33-86.73%, respectively. The data to be obtained as a result of the study, in addition to examining the mechanical harvesting of hazelnuts, will enable the reasons for the changes that may occur in the performance characteristics of existing machines to be explained and suggestions can be made for improvement.
Application of Nurses' Clinical Authority at Hospital X Jakarta
Authors: Lumban Tobing Masri Desy Suzanna , Tarigan Emiliana , Kusumaningsih Indriati
Published: March 2024

Clinical nurses ought to exercise their clinical authority in accordance with the provisions outlined in the Clinical Assignment Letter and Details of Clinical Authority, as well as complete the credentialing process. However, this implementation has not been fully utilized or communicated to staff at Hospital. The aim of this research is to identify the mechanism for implementing clinical authority for PK I-III nurses upon receiving SPK in the inpatient room at Hospital X Jakarta. The research design utilizes the qualitative approach of hermeneutic phenomenology, and data collection is carried out through in-depth interviews. A total of 17 participants are involved, including 14 clinical nurses (PK I: 6, PK II: 6, PK III: 2), as well as 3 managerial nurses (2 heads of inpatient units and 1 inpatient coordinator). The thematic data analysis follows the Colaizzi method, and 3 themes emerge from the research findings: the application of clinical authority for PK I-III nurses, the availability of management elements in the application of clinical authority for PK I-III, and the lack of optimal management functions in the application of PK. The application of clinical authority in this research encompasses independent and collaborative actions, and it is essential to strengthen regulations, resocialize, and implement an electronic system to facilitate processes. To ensure that nurses work according to their qualification level, hospitals should reinforce regulations and supervision, provide support and commitment, and resocialize SPO, SPK, and RKK.
A Case Study of Proverbial Treatment Towards Women in Balti Patriarchal Society
Authors: Anisa Fatima  , Saqlain Hassan  , Samsam Zulqarnain
Published: March 2024

The present study seeks to expose how Balti society has discursively constructed gender roles by translating proverbs. It examines how gender ideology affects translation processes and techniques the translator employs when translating proverbs. The research analyzes 14 proverbs responsible for gender dichotomy, selected from the book “Tam Lo” by Hasni (2004). Feminist Critical Discourse Analysis has been taken as a research perspective used in this study. For research methodology, Farahzad's Model (2009) of Translation Criticism has been utilized by the researchers in the current study. The findings reveal that in Balti androcentric society, women are viewed as unable, reliant, dependent, submissive, fractious, unfaithful, rude, sentimental, deceitful, deceptive, crafty, dim-witted, and unreliable in the eyes of the public. The study also discloses that a translator's ideology greatly impacts the translation process. This research will contribute to the already existing knowledge on gender studies of Balti society in particular and translation studies in general. Furthermore, this research will help raise awareness among Balti society, particularly among men, to refrain from exploiting women. Additionally, it is anticipated that study readers will create a stance of abstaining from gender discrimination.
وحی اور نبوت اور مغربی مصنفین : منٹگمری واٹ اور رابرٹ سپنسر کی آراء کا تقابلی جائزہ
Authors: Dr. Tariq Aziz  , Prof. Dr. Matloob Ahmad (Corresponding Author)  , Dr. Saima Muneer
Published: March 2024

It is an undeniable truth that the channel through which revelation became known to humankind is prophethood. Both revelation and prophethood are thus intertwined; the explanation of one will remain wanting without reference to the other. But majority of the Orientalists have tried their best to criticize and accuse Qur’anic revelation with a lot of misconceptions and allegations concerning wahy since dawn. So, this paper tries to find out the Orientalists view and concept on wahy based on the writings of western scholars. This paper gives high focus on analyzing their concepts and views related the issue and to answer and rectify the misconceptions describing the real facts and teaching of Islam in the issue related to wahy. So, this paper will be helpful to establish fact on Qur’anic revelation to the Prophet. Like other Orientalists, William Montgomery watt and Robert Spencer have actually denied Islamic scholars views about revelation and Prophet hood in their Qur’an commentaries. In this paper, an effort has been made to examine the arguments of both western scholars and to deduce the actual position about this topic. In this research written with a descriptive, comparative and analytical approach, it is proved that according to Quran, sciences of Tafsir and Hadith literature, history and logic, the explicit concepts of both scholars about revelation of the Prophet Muhammad (PBUH) are baseless and have been rejected with the arguments given by the majority of the Muslim scholars and thinkers.
The Art of Eating Right: Ahara Vidhi Vidhana in Ayurvedic Perspective
Authors: Sharon John  , Ananda Lakshmy K N  , Anjali Sivaram
Published: March 2024

Introduction : Maintaining health is influenced not only by the quantity and quality of food but also by the manner in which it is consumed. The processes of digestion, absorption, and assimilation involve intricate procedures influenced by physical, physiological, social, and emotional factors. To fully reap the benefits of food, adherence to specific guidelines is essential. Ayurveda provides insights into what, when, where, and how food should be consumed to optimize its effects on overall well-being. Aims and Objectives: To assess and compile information on diverse dietary and dining guidelines (Ahara Vidhi Vidhana) documented in Ayurvedic texts, examining their structure and effectiveness within the context of Charaka Samhita. Materials and Methods: The data for the review primarily collected from Ayurvedic Samhitas, including Charaka Samhita, Susrutha Samhita, Ashtanga Sangraha, Ashtanga Hridaya, and Sharangadhara Samhita. Observations: The guidelines are categorized into dietary rules and dining rules. The former outlines the types of food that should be consumed based on their quality and the individual's condition. The latter focuses on the manner in which food should be consumed, directly influencing both the hygiene of the food and the state of the mind. Conclusion: Both Ahara (diet) and Ahara Vidhi Vidhana (dietetic rules) are extremely significant in our day to day life . The appropriate application of both contributes to maintaining a healthy condition, while their improper utilization can lead to various diseases.
Lactation suppression effect of aqueous seed extract of Aframomum melengueta on female albino rats
Authors: Uche Emmanuel Olunkwa  , Kizito Munachiso Enyereibenyem Iheanacho  , Chidi Uzoma Igwe  , Linus Ahuwaraeze Nwaogu
Published: March 2024

Background and aims: Alligator pepper, a dietary spice used as food flavor enhancer is a common ingredient in pepper soup, a spicy delight in most parts of West Africa and possesses both medicinal and nutritive properties. Despite the well documented benefits of breastfeeding for mothers and infants, there are a variety of medical situations for which breastfeeding is contraindicated. Therefore, lactation suppression might be indicated for the best interest of the mother and/or infant. This study was undertaken to investigate the Lactation suppression effect of aqueous seed extract of Aframomum Melengueta on female albino rats. Methodology: Thirty (30) adult female albino rats weighing 160 to 200 g were used for the study while eighteen (18) albino mice of body weights (b.w.) range of 25 g to 30 g were used for the preliminary acute toxicity test. Male rats were introduced into the female rat cages of groups II-V within 12h at the expected estrous phase for mating and withdrawn thereafter. Groups I, II and III were orally administered distilled water only, while Groups IV and V received oral doses of 5 µg/kg b.w. Carbagoline and 3,000 mg/kg b.w. aqueous seed extract of Aframomum melegueta respectively 24 hours postpartum once daily by oral gavage for 3 days. Results: LD50 determination revealed no death was recorded among the animals up to 5000 mg extract/kg body weight. Study indicates that Aframomum melengueta extract elicited significant reduction of prolactin with corresponding increase in estrogen and progesterone in postpartum animals. Histological sections of the mammary gland show extensive fibrosis and congested ducts lobular units within the tissue stroma of the mammary gland of Aframomum melengueta treated animals. Conclusion: The results confirms a positive lactation suppression effect of aqueous seed extract of Aframomum Melengueta on postpartum lactating female albino rats
Prevalence of soil-transmitted helminths among school-aged pupils in three selected Community Primary Schools in Etche Local Government Area, Rivers State, Nigeria.
Authors: Rhoda Nwalozie  , Mary Egbukele  , Chinonye Oluchi Ezenwaka
Published: March 2024

Soil-transmitted helminths pose significant public health concerns, particularly among school-aged children in resource-constrained settings. This study aimed to investigate the prevalence of soil-transmitted helminths among school-aged pupils in three selected Community Public Primary Schools, Etche Local Government Area, Rivers State, Nigeria. A cross-sectional study was conducted, involving 150 school-aged pupils (1-14 years old) from three Community Primary Schools which included State School 1, State School 2, and Community Primary School, all in Etche. A structured questionnaire was administered to gather information on socio-demographic factors. Stool samples collected from each pupil were examined using the Kato-Katz technique and the STH parasites identified with keys. The overall prevalence of soil-transmitted helminth infection in the three selected schools in this study was 46%. Results obtained from this study according to sex showed that more males (52%) were infected than females (40%). Children between 5-7 years were the most infected in State School 2 and Community Primary School; while children between 12-14 years were the most infected in State School 1. Also, this study revealed that children in State School 2 had the highest soil-transmitted helminths infection (56%); while State School 1 recorded the least infection rate (34%). In this present study, Strongyloides stercoralis was the least prevalent soil-transmitted helminths while Ascaris lumbricoides (36) was the most occurring parasite in this study. There was no association (p>0.05) between age and gender and the prevalence of the parasite infection. A comprehensive control programme should be implemented in the area to curb the spread of infection.
Next generation of mRNA and lncRNAs based-vaccines platforms: Highlighted for HPV in head and neck squamous cell carcinoma, cervical and colorectal cancers and oncogenic viruses HBV/HCV in hepatocellular carcinoma
Authors: RACHEL SIQUEIRA DE QUEIROZ SIMÕES
Published: March 2024

More than 200 HPV genotypes and several HPV types associated with particular diseases as oral lesions (Hecks disease, oropharyngeal carcinoma, laryngeal papillomas), anogenital warts (Bowenoid papulosis, Buschike‒Lowenstein tumor), Epidermodysplasia verruciformis (plane warts, Pityriasis‒ like plaques, squamous cell carcinomas of sun‒exposed skin) have been described. Several advances in the genomics era and the development of new technological tools for next-generation sequencing have been showed that approximately 98% of RNAs are not translated into proteins. This study aims to succinctly describe long non-coding RNAs (lncRNAs) and their correlation with the hallmark of cancers since they comprise a class of RNAs that do not code for proteins. Oncogenic mutations occur with higher prevalence in non-coding regions, and the correlation of lncRNAs is extremely important for better understanding the biology of cancer cells as well as elucidating the molecular mechanisms underlying cancer. Thus, these may be promising tumor biomarkers and potential therapeutic targets exemplified in hepatocellular carcinoma, cervical and colorectal cancer induced by oncogenic viruses. Future studies are need to delve deeper into the cellular signaling pathways involved in biological processes. This theme addresses innovative issues on the ONU 2030 agenda from the perspective of global one health.
Public Private Partnership and Sustainable Development in Murang’a County, Kenya
Authors: Kimani Caroline , Ntara Caroline
Published: March 2024

This research interrogates the relationship between Public Private Partnership (PPP) and sustainable development in Murang’a County, Kenya. The research utilised descriptive and inferential statistics. The target population of this study were the 10 PPP projects that have been implemented in Murang’a County as at August 2023. The unit of study were the county government officials and private sectors partners for each PPP project. Census was used in this study where all the 10 PPP projects in Murang’a County were involved in this study. Regression results revealed that project financing, project service quality, project governance, and project environmental sustainability together account for 93.5% of the variation in the sustainable development in Murang’a County. The explanatory power of the model was statistically significant at a p value of 0.000. Further, the results revealed that project financing (β = 0.326, p < 0.000); project service quality (β = 0.273, p < 0.000); project governance (β = 0.356, p = 0.004); and project environmental sustainability (β = 0.687, p < 0.000) had a positive and significant effect on sustainable development in Murang’a County, Kenya. Based on the findings, it is recommended that there should be an enhancement in project governance structures and financial management practices, rigorous adherence to environmental sustainability, and a relentless focus on improving service quality to ensure the successful implementation of sustainable development projects.
Impact of Socio- Economic Status on the Educational Achievement of Secondary School Students in Vadodara
Authors: Saxena Preeti , Yadav Neetu
Published: March 2024

With the onset of COVID-19 pandemic, most of the students and their families were affected by economic burden and became unemployed. Those who had business also suffered, unemployment in India effected the future of the students and their parents.  Paying fees in schools became a problem for parents.  Many students lost their father or mother.  Research has shown that the effect of socio-economic status on the academic achievement of students was observed due to corona.  Many parents are not educated.  If the size of the family is large, then out of 4 children, one or two children are not able to get admission in the school.  The present study will help us to know the importance of the situation of our country along with the academic achievement of students.  The objective of this present study is to know the socio-economic status of secondary school students of Vadodara district and the problems faced by them in their academic achievement. There are many factors affecting academic achievement. psychological, social, economic and environmental etc. The objectives of the study were to identify the level educational achievement of secondary school students of Vadodara City and to examine the influence of socio-economic status on the educational achievement of secondary school students The descriptive survey method was used for the present study. 50-students and parents of the two Hindi medium schools namely Shri Krishna Hindi Vidyalaya and Adarsh Hindi Vidyalaya were selected as the sample for the present study. It has been found in the present study that the academic achievement of low-level students, average level students, high level students were investigated the level of all the students, mean scores of high-level students were 212 and the marks of average level students were 142 and the lowest low level of students is 57. To see the impact of socio-economic status on educational achievement, t-test was conducted, it was found that statistically there exists no significant difference in socioeconomic status and educational academic achievement It becomes important to be conclude that even the status of social or economic level is low but efforts can be made to attain expected educational achievement and lead to a totally developed personality for which education is aimed for.
Influence of Nutrition and Genetics on Bone Parameters of 1940 Leghorn and 2016 Commercial White Leghorns
Authors: C Wall Dannica
Published: March 2024

Bones play an essential role being responsible for the support of body mass, protection of internal organs, and providing musculature attachment sites while also serving as a reservoir for eggshell mineralization during the production phase. Targeted genetic selection has contributed to body morphometry and performance potential and could be inadvertently associated with undesirable effects on bone stability. In this study, bone parameters were compared between a contemporary and heritage line for the effect of strain and dietary regimen. A total of 320 White Leghorn laying hens (69 weeks of age) of two different strains were distributed into a 2 × 2 factorial arrangement creating 4 experimental treatment groups: 1). 2016 hen on 1940 diet, 2). 2016 hen on 2016 diet, 3). 1940 hen on 1940 diet, and 4). 1940 hen on 2016 diet with 8 replicates per treatment. Keel bones were assessed for deviations and or fractures. Significant differences (P ≥ 0.05) were observed for both deviations and/or fractures with the 2016 strain having more when compared to the 1940 strain. Humerus and tibia bones were analyzed for bone mineral density, breaking strength, and bone ash. Humerus and tibia weights which included both pre (with meat attached) and post weights (without meat attached) had significant differences (P ≤ 0.05) in the pre-weight in the 2016 hens, however no significant differences in the post weights. Results suggest that genetics played a role in the differences observed with the bone parameters measured and nutrition had few adverse effects.
COMPARISON OF THE EFFICACY OF INTRALESIONAL 5% FU VERSUS INTRALESIONAL TRIAMCINOLONE IN PATIENTS PRESENTING WITH KELOID AND HYPERTROPHIC SCAR AT TERTIARY CARE HOSPITAL, KARACHI
Authors: SHAH B , GHAFOOR R , ASAD N , SAMEE A , SURHIYO M , SATTAR A
Published: March 2024

Despite the fact that keloids and hypertrophic scars are frequent benign hyper-proliferative growths of dermal fibroblasts, the clinical concerns, such as physical and psychological issues, are serious and impairing, and there are few effective therapies. Although 5-fluorouracil (5-FU) and intralesional triamcinolone acetonide (TAC) are widely used to manage both scars, their effectiveness is still debatable. To compare the efficacy of intralesional 5% FU versus intralesional triamcinolone in patients presenting with keloid and hypertrophic scar at Tertiary Care Hospital, Karachi. This RCT study was conducted on patients presenting with keloid and hypertrophic scars at the Outpatient Department of Dermatology, JPMC, Karachi, meeting inclusion criteria. A brief history of demographic information and written informed consent were taken from each patient. A total of 158 patients were enrolled in the study and were randomly allocated to Group A, Intralesional triamcinolone group, and B: Intralesional 5% FU group twice weekly for a total of 4 sessions. During each visit, the keloid height was measured, photographed again, and documented. Efficacy was labeled if patients with keloid and hypertrophic scar in either group showed ≥ 50% reduction in height. Comparison of efficacy between groups showed a significant difference as the efficacy rate was higher in patients treated with 5-FU 45mg as compared to the patients administrated with TAC 10mg (70.9% vs. 50.6%; P-value=0.009). This analysis revealed that irrespective of the patient's age, sex, illness duration, or lesion site, intra-lesional 5-fluorouracil (5-FU) offered the significant benefit of a faster and more effective response than triamcinolone (TAC) in the treatment of keloids and hypertrophic scars.
Diseño y análisis de una bebida deportiva a base de betabel
Authors: Ponce Dávila Emmanuel Omar , Neder Suárez David , Muñoz Daw María de Jesús , Carrasco Legleu Claudia Esther , Benítez Hernández Zuliana Paola
Published: March 2024

Objetivo: Desarrollar una bebida deportiva a base de betabel, con contenido significativo de nitratos, nitritos, polifenoles, antioxidantes totales y betalaínas, con propiedades organolépticas aceptables. Metodología: Se diseñaron tres bebidas con diferente formulación, todas las bebidas deportivas se analizaron microbiológicamente y químicamente cuantificando los compuestos bioactivos de interés, por último, las bebidas fueron evaluadas por 96 jueces consumidores en un análisis sensorial. Resultados: Las bebidas se elaboraron cumpliendo con los parámetros microbiológicos que exige la normativa mexicana (NOM´s), sensorialmente las bebidas 138 y 790 obtuvieron una puntuación de –agradable- sin diferencias significativas en ninguno de los parámetros, la bebida de betabel, manzana cacao y té verde tuvo un contenido por porción (200 ml) de 31.74 mmol/l, así como un alto contenido de polifenoles (33.95 ± 0.7 mg BC/g b.s*), un mayor contenido de betacianina y betaxantinas (8.67 y 5.23 mg BC/g b.s*) que las demás muestras sin diferencia significativa y un contenido de antioxidantes totales (4.76 ± 0.23 micromol de trolox/g de muestra). Conclusión: Se puede concluir que se eligió la bebida deportiva de betabel manzana té verde y cacao debido a su aceptación sensorial y su contenido bioactivo.
Composite adverse events compared early versus conventional cessation of hydrocortisone in patients with septic shock: Randomized-controlled trial (The CESSHYDRO study)
Authors: Kangwanyotsak Kolanya , Tongyoo Surat
Published: March 2024

Background: Intravenous hydrocortisone has benefits in the treatment of septic shock patients, but there are adverse events mentioned in the secondary outcomes of several studies, such as hyperglycemia, hypernatremia, secondary infection, and muscle weakness. In addition, there are no recommendations regarding the precise duration and steps to discontinue hydrocortisone administration. The CESSHYDRO trial evaluates the adverse outcomes of intravenous hydrocortisone between early cessation versus conventional cessation of hydrocortisone in septic shock patients.
Methods: The CESSHYDRO trial is a single-center, double-blind, randomized controlled clinical trial conducted at Siriraj Hospital. One hundred and eighty septic shock patients receiving vasopressors and hydrocortisone at least 200 mg/day with hemodynamic stability will be included. The patients are randomized into 2 groups: intervention A (early cessation of hydrocortisone) and intervention B (conventional cessation). The primary outcomes were composite adverse events, including hyperglycemia, hypernatremia, muscle weakness, and new infections.
Hypothesis: We hypothesize that early cessation of hydrocortisone in patients with septic shock would reduce composite adverse events including hyperglycemia, hypernatremia, muscle weakness, and the new onset of infection.
Ethics and dissemination: The trial receives ethical approval from Siriraj Hospital, Mahidol University (COA No.SI012/2023).
Trial registration: ClinicalTrials.govNCT05818826. Registered on April 19, 2023.
A Frequency Reconfigurable Graphene-Based Microstrip Antenna with Mushroom-Like EBG
Authors:   College of Engineering, Al-Qadisiyah University, Iraq, Nora Nora ,   College of Engineering, Al-Qadisiyah University, Iraq,   College of Engineering, Al-Qadisiyah University, Iraq,   Federal Board of supreme audit, AL- Diwaniyah, Iraq, .. Ghufran abdulqader , J. Marwa S.. , Radeef Hasanain Jawad
Published: March 2024

The growing demand for wireless applications has led to network congestion issues. In response, network operators have recommended a transition to higher frequencies, particularly within the unlicensed millimeter-wave (mm-wave) spectrum. This shift aims to fulfill users' desires for rapid data transmission within personal networks, whether at home or in the office, exemplified by technologies like WiGig technology and indoor applications. However, a significant challenge in achieving high data transfer speeds within this frequency range lies in the design of the antenna. These antennas must strike a balance between size and performance. Microstrip Patch (MP) antennas have gained recognition for their compact form and seamless integration into mobile communication systems. Nonetheless, they grapple with limitations such as poor gain and narrow bandwidth, largely attributable to surface waves negatively impacting antenna performance. In this study, we introduce, design, and optimize an MP antenna tailored for 60 GHz applications. To enhance the performance of the MP antenna, we introduce various mushroom-like Electromagnetic Bandgap (EBG) structures. These structures address the propagation of the surface waves issue that affects the antenna performance. Additionally, to create a tunable frequency antenna the variable conductivity of the graphene material is used in the form of implanted slots on the patch and tuned by applied DC voltage on the slots. Finally, the parameters of the MP antenna undergo enhancement based on simulation results obtained through CST software.
Age-dependent trends in compressive strength of concrete incorporating fly ash
Authors: Akhazhanov Sungat , Tleulenova Gulshat , Karaulov Sabit , Zharassov Shyngys , Mukhamejan Alisher
Published: March 2024

The research investigates the transformative potential of fly ash, an industrial byproduct, in enhancing concrete compressive strength and addressing environmental concerns associated with its disposal. The study employs a rich dataset from Mendeley Data, comprising 471 data points, to comprehensively explore the impact of fly ash on concrete strength at different ages. The analysis involves determining optimal compositions with fly ash, evaluating the fraction of cement replacement, and analyzing the generalized effect on compressive strength through graphical representation. Results reveal an inverse relationship between fly ash content and compressive strength, with nuanced patterns emerging at different curing ages. Despite the negative correlation, opportunities exist to optimize concrete formulations for specific strength requirements by judiciously incorporating fly ash. The weighted sum analysis identifies a composition with 33.6% replacement of binder by fly ash as optimal in the long term, showcasing the potential of this waste product as a valuable resource in sustainable concrete engineering.
Study of the pore structure of foam concrete using a two-stage foaming method
Authors: Lukpanov Rauan , Dyussembinov Duman , Altynbekova Aliya , Zhantlessova Zhibek , Smoljaninov Anatolij
Published: March 2024

This study presents an in-depth analysis of the pore structure in foam concrete, manufactured using a novel two-stage foam introduction method, with a comparative assessment against traditional foam concrete. Pore structure evaluation was conducted through visual-instrumental inspection and measurements of pore areas in segmented samples, including upper, middle, and lower segments. The results indicate that the proposed foam introduction method Type 1 results in a more stable pore structure distribution compared to classical foam concrete Type 2. In the upper segment, Type 1 samples exhibit an average pore content of 28.977%, while Type 2 samples show 36.112%. Similarly, in the middle segment, Type 1 samples display 27.147%, and Type 2 samples demonstrate 28.410%. The lower segment of Type 1 samples displays 24.054%, with Type 2 samples showing 22.136%. The differences in pore volumes between the lower and upper segments are 12% for Type 1 and 27.11% for Type 2, demonstrating a significant variation in the quality of the pore structure. This research sheds light on the advantages of the proposed two-stage foam introduction method in enhancing the stability and quality of foam concrete's pore structure, with potential implications for its use in various construction applications.
Versatility of antero-lateral thigh free flap in reconstruction of defects in different parts of body - our experience
Authors: Mohanty Rasmi , Mishra Rojalin , Dash Amitabh , Nayak Bibhuti
Published: March 2024

Extensive soft tissue defects pose a great deal of challenge to the reconstructive surgeon. The aim of this study is to analyze the outcome of free anterolateral thigh (ALT) flaps for soft tissue reconstruction of defects following tumor excision, trauma and post burn. A retrospective review of 19 patients undergoing ALT Flaps for various reasons from Dec 2018 to Jan 2021 was performed to determine perioperative factors, demographic profile, complications and outcomes. The mean age of the study population was 47.2 years. The male to female ratio was 2.16:1 (68.5 % male, 31.5% females). The etiology of soft tissue defect was post-tumor resection-47.36%, truam-36.8%, post burn reconstruction-10.5%. The defect sites were most commonly leg-31.5%, upper extremity-26.3%, buccal mucosa-15.7%, scalp-10.5%, tongue-10.5%, breast-5.2%. Flaps were harvested from right thigh in 52% of cases and left thigh in 58% of the cases. Donor site was closed primarily in 11 cases (57.8%), SSG coverage was done for 8 cases (42.8%). The minimum hospital stay post op was 12 days, maximum being 45 days. Postoperative complications were seen in 36.8% of the cases. Partial flap necrosis occurred in 3 cases (15.7%), complete necrosis in 1 case (5.2%), donor site morbidity was seen in 3 cases (15.7%). In the post-operative period hematoma and infection occurred in 3 cases. ALT Flap in experienced hands provide reliable coverage of large soft tissue defects with excellent aesthetic and functional outcomes with minimal donor site morbidity.
Fertility testing of preserved epididymal sperm by microinjection: A model for the rescue and utilization of genetically superior animals
Authors: Prastowo Sigit , Widyastuti Rini , Jaswandi Jaswandi , Boediono Arief
Published: March 2024

Background:
Epididymal sperm preservation is a simple conservation approach that can help prevent the loss of high genetic quality of farm animals. The chance of loss increases, especially during disease outbreaks or other interruptions to normal reproduction function.
Aim:
This study looked into the ability of preserved ram epididymal sperm to fertilize oocytes. Due to motility becoming an issue following sperm storage for fertilization, the sperm micro injection of known as intracytoplasmic sperm injection (ICSI) approach was employed.
Methods:
The study was divided into two parts. First, involved preservation of epididymal sperm at 5°C for 12 days. During preservation, sperm quality parameters namely motility, viability, intact membrane, acrosome, and DNA are evaluated every three days. For fertility test in the second experiment, matured oocytes were injected with immotile sperm discovered in the last days of preservation. The presence of pronucleus development following in vitro culture is used as an indicator of sperm ability to activate and fertilize oocytes.
Results:
All sperm quality parameters significantly (p<0.05) declined during preservation time. On day 12, motility was discovered to be 0%, but viable sperm, sperm with intact membrane, acrosome and DNA remained at 41.86±9.30, 31,18±5.15, 21,88±1.93 and 33.35±8.74%, respectively. On the fertility test, we inject immotile sperm from day 12 of preservation, which has lowest motility found, into matured oocytes. Those sperms are able to activated (52.05±7.15%) and fertilize (31.37±1.75%) the injected oocytes, but their fertilizing ability is significantly lower (p<0.05) when compared to the sperm derived from ejaculate.
Conclusion:
In this study, simple preservation of epididymal sperm reduces all sperm quality criteria, particularly motility. Using the microinjection approach preserved sperm which no motility, still demonstrated its ability to activate and fertilize the oocytes. According to that, this study provides potential approaches and tools for using genetically superior animals that have lost their ability to execute regular fertilization, and also prolonging reproduction function.
Genomic characterization and probiotic potential of lactic acid bacteria isolated from feces of guinea pig (Cavia porcellus)
Authors: Vargas Jos , Alor Max , Pachorro Fidel , Jorge Wilson , o Arnold , Parra Edson , Mialhe Eric
Published: March 2024

Background:
Presently, there exists a growing interest in mitigating the utilization of antibiotics in response to the challenges emanating from their usage in livestock. A viable alternative strategy encompasses the introduction of live microorganisms recognized as probiotics, exerting advantageous impacts on the immune system and nutritional aspects of the host animals. Native lactic acid bacteria, inherently possessing specific properties and adaptive capabilities tailored to each animal, are deemed optimal contenders for probiotic advancement.
Aim:
In the current investigation, microorganisms exhibiting probiotic potential were isolated, characterized, and identified from the fecal samples of guinea pigs (Cavia porcellus) belonging to the Peruvian breed.
Methods:
The lactic acid bacteria isolated on MRS agar underwent Gram staining, catalase testing, proteolytic, amylolytic, and cellulolytic activity assays, low pH tolerance assessment, hemolytic evaluation, antagonism against Salmonella sp., determination of autoaggregation and coaggregation capacity, and genotypic characterization through sequencing of the 16S rRNA gene.
Results:
A total of 33 lactic acid bacteria were isolated from the feces of 30 guinea pigs, with 10 selected based on Gram staining and catalase testing. All strains exhibited proteolytic activity, although only one demonstrated amylolytic capability, while none displayed cellulase activity. These bacteria demonstrated higher tolerance to pH 5.0 and, to a lesser extent, to pH 4.0. Furthermore, they exhibited antagonistic activity against Salmonella sp. Only 2 bacteria demonstrated hemolytic activity, and they were subsequently excluded from further evaluations. Subsequent assessments revealed autoaggregation capacities ranging from 4.55% to 23.19%, with a lesser degree of coaggregation with Salmonella sp. ranging from 3.53% to 8.94% for the remaining 8 bacterial isolates. Based on these comprehensive tests, 5 bacteria with notable probiotic potential were identified through molecular assays, belonging to the groups Leuconostoc citreum, Enterococcus gallinarum, Exiguobacterium sp., and Lactococcus lactis.
Conclusion:
The identified bacteria stand out as promising probiotic candidates, deserving further assessment in Peruvian breed guinea pigs. This exploration aims to enhance production outcomes while mitigating the adverse effects induced by pathogenic microorganisms.
The impact of Apis dorsata forest honey administration on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in rats (Rattus norvegicus) forced swim test as a chronic physical animal model
Authors: Widjiati Widjiati , Luqman Epy , Kuntjorodjakti Suryo , am Aulanni , Shabira Zahra , Taqwa Sultan , Mega Riski , Chou Dean , Mubarak Ahmad , Hendrawan Viski
Published: March 2024

Background:
Chronic physical stress has many effects on the nervous system and can cause structural changes in different parts of the brain and hemomodulatory, including hormonal. Current pharmacotherapeutic treatments have limited efficacy and are associated with many deleterious side effects
Aim:
The aim of this research is to determine how apis dorsata forest honey administration affects FSH and LH levels in rats who are subjected to forced swim tests as a model of chronic physical stress placed in a container filled with water from which it cannot escape.
Methods:
This was an experimental laboratory study with 32 rats divided into four treatment groups: control (C), Treatment 1 (T1) with a forced swim test + honey (2 g/rat/day), Treatment 2 (T2) with a forced swim test + honey (4 g/rat/day), and Treatment 3 (T3) with a forced swim test + honey (6 g/rat/day). All treatments were administered for 14 days. Then blood was taken for FSH and LH serum tests, and a one-way ANOVA and Duncan test were used to statistically test the data analysis.
Results:
The results of this study indicate that the administration of forest honey had no significant effect (p > 0.05) on the FSH parameter, but there was a significant decrease in LH levels in the T2 and T3 groups (p<0.05).
Conclusion:
It can be concluded that giving forest honey to rats who were subjected to a 14-day forced swim test had no effect on FSH and LH levels. In rats given a forced swim test as a model of chronic stress, administration at doses of 4 g/rat/day and 6 g/rat/day reduced LH serum levels.
Simultaneous surgical repair of a cardiac myxoma causing left ventricular outflow tract obstruction and a ventricular septal defect in a small dog
Authors: Mihara Kippei , Kanemoto Isamu , Ando Takanori , Kawase Koudai , Iguchi Kazuhito , Yokoyama Satoko , Asai Atsushi , Hoshi Katsuichiro
Published: March 2024

Background:
Cardiac myxomas are benign tumors that can occur in any heart chamber or valve. They are extremely rare in dogs. We present a novel case involving a cardiac myxoma in the left ventricular outflow tract (LVOT) and a ventricular septal defect (VSD) in a small dog.
Case Description:
A female miniature dachshund (age, 7 months; weight, 2.88 kg) presented with growth insufficiency, lethargy, and a cardiac murmur. Echocardiography revealed a small polypoid mass in the LVOT and a membranous VSD. Simultaneous surgeries were performed to resect the mass (aortotomy) and close the VSD (right atriotomy) using low-flow cardiopulmonary bypass with surface-cooling hypothermia and retrograde cardioplegia. The tumor was histopathologically identified as a myxoma. The dog survived with no cardiac complications for 11 years after surgery.
Conclusion:
To our knowledge, this is the first report of ante-mortem diagnosis and simultaneous surgical repair of a cardiac myxoma obstructing the LVOT and a VSD in a small-breed dog. In addition to describing this complicated case, this report presents what we believe is the first reported use of retrograde cardioplegia during open-heart surgery in a small-breed dog.