bluuebunny/crossref_metadata_2025 huggingface dataset:
A De Novo Mutation Destroys the Central Repeated Domain of TCOF1 in a Chinese Family with Treacher Collins Syndrome
Authors: Jiang Zhuoyuan , Mao Ke , Wang Bingqing , Chen Qi , Li Ying , Zhao Shouqin , Zhang Qingguo , Liu Huisheng , Zhang Yongbiao
Published: December 2022

Treacher Collins syndrome (TCS, MIM #154500) is a severe congenital disorder implicated in particular dysplasia of the craniofacial bones, accompanied by downslanting palpebral fissures, lower eyelid colobomas, microtia, or other craniofacial malformations. However, the underlying pathogenic mutations in TCS are still unknown, and elucidating these is of primary importance for TCS researchers. We collected samples from a Chinese TCS family, including the proband and two parents. Sequencing, genotyping, and in silico analyses were employed to detect pathogenic mutations in the pedigree. In the proband, a de novo frameshift mutation of TCOF1 c.1562_1574del (p.A521fs) was identified as a pathogenic candidate, while the parents showed no mutations. The frameshift mutation results in TCOF1 truncation and damages the central repeat domain, which is the binding site for transcriptional factors. In conclusion, we identified a novel mutation TCOF1 c.1562_1574del, which is likely a pathogenic mutation for TCS, thereby expanding the mutation spectrum of TCS.
Temporal relation between human mobility, climate and COVID-19 disease
Authors: Grimm Alice M , Mendes Carlos FO , Brugnago Eduardo L , Beims MW
Published: December 2022

Using the example of the city of São Paulo (Brazil), in this paper, we analyze the temporal relation between human mobility and meteorological variables with the number of infected individuals by the COVID-19 disease. For the temporal relation, we use the significant values of distance correlation t0(DC), which is a recently proposed quantity capable of detecting nonlinear correlations between time series. The whole period analyzed goes from Feb 26th to Jun 28th, 2020. Fewer movements in Recreation and Transit Stations and the increase of the maximal temperature, {have strong correlations with the number of newly infected cases occurring 17 days after. Furthermore, more significant changes in Grocery and Pharmacy, Parks and Recreation, and sudden changes in the maximal pressure occurring at 10 and 11 days before the disease's beginning are also correlated with it. Scanning the whole period of the data, not only the early stage of the disease, we observe that changes in human mobility primarily affect the disease for 0 to 19 days after. In other words, our results demonstrate the crucial role of the Municipal Decree declaring an emergency in the city to influence the number of infected individuals.
Enhanced cloud security protocols for data protection in the Internet of Healthcare Things (IoHTs) using Entangled Fuzzy Logics
Authors: Gopinath N
Published: December 2022

The medical internet of things (MIoTs) is essential for enhancing people's protection, care, and health. Health-related criteria for patients can be remotely tracked and transferred to medical data centers via cloud storage, saving them the trip to the hospital. Additionally, the volume of data processed by MIoTs devices is growing exponentially. Due to the increased revelation of sensitive information, there are many unresolved issues about data security and privacy gathered through MIoTs devices. The requirement to apply machine learning algorithms to massive industrial data is developing as quickly as categorization methods themselves. We offer an Entangled Fuzzy Logic based Quantum Key Distribution (EFL-QKD) for data protection to improve and assess the degree of security such breaches, data integrity, etc. in order to safely store and handle this information in the cloud. Results show that the proposed method enhancing the level of security to the cloud more than 99%, the works remarkably well.
Efficient ZIF-67 alginate composite hydrogel material and its application to enhanced copper (II) adsorption from aqueous solutions
Authors: fu hua , chen huiyuan , song weijun
Published: December 2022

Metal-organic framework materials(ZIF-67) were loaded on Sodium alginate/polyvinyl(PVA/SA) hydrogel by in situ growth method for adsorption of heavy metal Cu (II). The structure of hydrogels composited with MOFs and polymers was designed to improve the poor mechanical properties of natural polymer gel materials and the inconvenience of powdered MOFs materials in practical applications. Synthesized hydrogel spheres were characterized by FT-IR, SEM, XRD, XPS, etc. The adsorption results showed that the optimum adsorption process of Cu (II) pH was 5.0. The adsorption kinetics and isotherm suggest that the adsorption process follows the Freundlich isotherm and the pseudo-second-order models. The experimental maximum adsorption capacity was 128.4 mg/g, 3.3 times and 1.8 times higher than ordinary SA and PVA/SA hydrogel spheres. The selectively experimental results show that PVA/SA@ZIF-67 exhibits better adsorption performance (especially for ion Cu(II), Pb(II) ) and it also indicates that PVA/SA@ZIF-67 has application potential when applied in some specific fields of wastewater treatment. More importantly, PVA/SA@ZIF-67 exhibited exceptional mechanical stability and showed excellent recycling capability in the cyclic adsorption process.
Highly immune-related genes of breast cancer: potential diagnostic and prognostic biomarkers
Authors: Yang Beibei , Chen Xi , Zhang Wei , Zou Liqun
Published: December 2022

Although immune checkpoint inhibition (ICI) has shown therapeutic promise in breast cancer, there is considerable heterogeneity in its efficacy. Therefore, our study aimed to explore effective biomarkers for identifying patients most likely to benefit from immunotherapy. In our study, differentially expressed genes from the Cancer Genome Atlas breast cancer dataset were first identified using the R package limma; they were then intersected with the list of immune-related genes obtained from the ImmPort and InnateDB databases to obtain 542 immune-related differentially expressed genes for breast cancer. Twelve immune-related hub genes and three independent prognostic genes (S100B,NPR3, andSDC1) were then identified by weighted gene coexpression network analysis and multivariate Cox regression analysis, respectively. Furthermore, the accuracy of the prognosis prediction model (IRGRS) constructed by these three genes (S100B, NPR3, and SDC1) for breast cancer patients was further verified in four GEO data sets. In addition, we predicted the matrix and immune components in the high- and low-risk scores groups, and found that the low-risk score group had a higher Immune Score and a better prognosis. The drug response prediction analysis also found that the IC50 values of Bleomycin, Gemcitabine, Lapatinib, and Paclitaxel were lower in the low-risk score group than in the high-risk score group. The IRGRS constructed in this study may potentially differentiate the prognostic, molecular, and immunological features of breast cancer.
The benefits of music therapy on preterm infants in the intensive care unit
Authors: Leivas Kayene Alcântara , Ramos Laís Zanchetta , Piperno Giulia Caroline , Alves Ana Flávia de Jesus , Kawata Cíntia , Sabino Henrique Augusto Cantareira , Molinari Beatriz Carmona
Published: December 2022

This clinical study seeks to demonstrate the benefits that music therapy (MT) can provide, by the analysis of heart rate (HR), respiratory rate, peripheral oxygen saturation and the Neonatal Facial Coding System (NFCS) pain scale on preterm (PT) neonates hospitalized in the neonatal intensive care unit, where they are exposed to factors which are stressful and harmful to their health. During the period between March and September 2022, each hospitalized PT neonate was submitted to a single 20 minutes music therapy session with non-classical instrumental music without voice. A total of 17 PT neonates were included in the analysis of this study. The data collected demonstrated that MT was beneficial in stabilizing vital signs with an average reduction in HR of 12 beats per minute during the therapy (p = 0.012).
Conclusion: Music therapy is capable of stabilizing vital signs such as heart rate in a single session and reducing the stress of the neonate.
Cost-utility analysis of eribulin versus capecitabine in HER-2 negative advanced or metastatic breast cancer in China
Authors: Hong Wanglong , Shen Aizong
Published: December 2022

Objective: To evaluate the cost-utility of eribulin versus capecitabine in the treatment of HER-2 negative advanced or metastatic breast cancer(AMBC).
Methods: Based on the data of a phase III trial, a partition survival modelwas constructed with a study duration of 10 years. Uncertainty analysis were used to evaluate the robustness of the results.
Results: The results showed that compared with capecitabine group, the eribulin group obtained 0.24 more QALY, spent $5287.11 more, and ICUR was $22084.93/QALY, which was less than the threshold. uncertainty analysis showed that the results were robust, and the probability of eribulin being cost-utility is 69.28% at the threshold of $33881.17.
Conclusions: Eribulin is cost-utility than capecitabine in the treatment of HER-2 negative AMBC.
Association of Serum Neurofilament Light Chain with Depressive Symptoms: a population-based study
Authors: Zhang Hui
Published: December 2022

Background
Neurofilament light chain proteins (NfL) are widely accepted biomarkers of neuronal injury, and depressive symptoms are related to neuronal injury. Nevertheless, evidences of the association between NfL and depressive symptoms are still limited. This is the first population-based study to examine the association between NfL and depressive symptoms in general population.
Methods
We included 1907 participants with measurement of serum NfL from the 2013–2014 U.S. National Health and Nutrition Examination Survey. Depressive symptoms were measured by the 9-item Patient Health Questionnaire. Logistic regression models were conducted to examine associations between serum NfL levels and depressive symptoms. Restricted cubic spline regressions were applied to estimate the possible nonlinear relationships between them.
Results
Increased serum NfL were associated with higher risk of depressive symptoms after adjusted for confounder factors (per SD: odds ratios [OR] = 1.16, 95% confidence intervals [CI]: 1.02–1.34). Individuals with higher serum NfL (> 21.8 pg/ml, the upper 20% quantile) had a higher likelihood of depressive symptoms compared to normal counterparts (OR = 1.50, 95% CI: 1.01–2.22), and sensitivity analysis using different grouping criteria provided similar results. Furthermore, restricted cubic spline regression analysis demonstrated that a near-linear association occurred between serum NfL and the risk of depressive symptoms (P-nonlinear = 0.681, P-overall < 0.001).
Conclusions
This study found linear association between serum NfL levels and depressive symptoms in general population. Our findings support that serum NfL levels may be a novel biomarker for depressive symptoms, further studies are needed to validate our findings underlying this association.
Comparison of Visual Performance between Monofocal and Rotationally Asymmetric Refractive Intraocular Lenses
Authors: Miyoshi Masaki , Tanabe Hirotaka , Shojo Tomohiro , Yamauchi Tomofusa , Takase Kosuke , Tabuchi Hitoshi
Published: December 2022

We compared the visual performance of a monofocal intraocular lens (IOL) (ZCB00) and a rotationally asymmetric refractive IOL with + 1.5 diopters near addition (Lentis Comfort LS-313 MF15) by investigating postoperative parameters ten weeks after surgery from both eyes of cataract patients who underwent bilateral implantation with one of the two IOLs within three months between 2011 and 2019. A total of 1352 eyes of 676 patients were enrolled; the ZCB00 group comprised 904 eyes of 452 patients (72.3 ± 6.8 years; females/males, 268/184), and the LS-313 MF15 group included 448 eyes of 224 patients (73.6 ± 7.0 years; females/males, 125/99). A linear mixed-effects model using data for both eyes, with strict adjustments for sex, age, subjective refraction spherical equivalent, subjective refraction cylinder, corneal astigmatism, axial length, corneal higher-order aberrations, and pupil diameter, ensured statistical validity. Corrected distance visual acuity was significantly better, and the higher-order aberrations (ocular/internal, scaled to a 4/6-mm pupil; WF_4_post_O_TotalHOA, _Third, _Fourth, _Trefoil, _Coma, _Tetrafoil, _Spherical; WF_4_post_I_TotalHOA, _Third, _Fourth, _Trefoil, _Coma, _Tetrafoil, _Spherical, WF_6_post_O_Spherical, and WF_6_post_I_Spherical) were significantly smaller in the ZCB00 group (p < 0.00068, Wald test). Contrast sensitivity with glare (6.3 degrees) and spectacle independence (near) were significantly better in the LS-313 MF15 group (p < 0.00068, Wald test).
SIMULATION OF CAR-PEDESTRIAN CRASH: INJURY ASSESSMENT AND IMPACT POSITIONS
Authors:   P.G Student, Hunan University, China., Peter Chol Duom
Published: December 2022

In car-pedestrian collisions, pedestrian fatal injuries account for a great number of health risks in the world. A real-world accident case with a medical examination record would improve the reliability of simulation of car-pedestrian accidents but is rarely captured. The goal of this report was to assess the pedestrian injuries, and impact positions. A case of a pedestrian impacted by a car traveling at a speed of 22 km/hr was simulated using the MAthematical DYnamic MOdel (MADYMO) program. The results showed that Abbreviated Injury Score one (AIS1) head injury and Abbreviated Injury Score two (AIS2) toe fracture are caused by pedestrian impact with windshield and wheel. The maximum head linear acceleration and right foot force that led to head injuries and toe fractures are 1688.61 m/s2 and 15799.00 N, respectively. The results obtained in terms of head impact location, left forearm impact, and the right foot impact positions are comparable with the real-world road accident. This report can help in the future design of automobiles that are friendly to vulnerable pedestrians.
An Austinian Account of Knowledge Ascriptions
Authors: Vilaró Ignacio
Published: December 2022

According to epistemic contextualism, the truth value of a knowledge ascription sentence varies in relation to the epistemic standard in play at its context of use. Contextualists promise a relatively conservative (dis)solution of the skeptical paradox that threatens to destroy our alleged everyday knowledge, based on our apparent inability to discard some exotic possibilities of error. The origins of the contextualist position have been traced back to some passages of Austin’s “Other Minds.” However, it is at best dubious whether the alternative there explored is indeed contextualist. Austin seems to be proposing a much more radical position, one still ignored in the literature. This paper aims to develop an Austinian approach to knowledge attributions. I show how we could use the Austinian account to solve this skeptical paradox. I also respond to some important objections to this view.
La crítica de J. M. Keynes al proyecto de matematizar la probabilidad de J. Bernoulli
Authors: Aristimuño Francisco Javier
Published: December 2022

A cien años de la publicación de A Treatise on Probability, de J. M. Keynes, este artículo indaga sobre su relevancia en la historia del concepto de “probabilidad”. Tras repasar el surgimiento y evolución del concepto moderno de “probabilidad” hasta principios del siglo XX, se identifica un punto nodal en la publicación del Ars Conjectandi de J. Bernoulli a principios de siglo XVIII, en donde se propuso de forma original tratar el campo completo de las conjeturas probables mediante el herramental matemático de la doctrina de las posibilidades. El artículo busca comprender el Treatise keynesiano como una reacción a dicho proyecto encarnado en el siglo XVIII por la escuela clásica laplaciana y en el XIX por la escuela frecuentista. Tras presentar los principales argumentos de Keynes en contra de la concepción de la probabilidad como una entidad necesariamente medible y, por ende, tratable mediante el herramental matemático de la doctrina de las posibilidades, se extraen reflexiones sobre la relevancia y actualidad del Treatise.
La condición humana en Nietzsche. Una reflexión a partir de Zaratustra
Authors: González Vallejos Miguel
Published: December 2022

Este artículo reconstruye la reflexión de Nietzsche acerca de la condición humana desarrollada a lo largo de su obra central, Así habló Zaratustra. El punto de partida del análisis es el discurso en el mercado situado en el prólogo de la obra, en el que Zaratustra proclama por primera vez el advenimiento del superhombre. La reconstrucción de su posición antropológica supone la consideración de algunos pasajes especialmente relevantes en los que el autor se refiera a la muerte de Dios, al último hombre y el superhombre, la voluntad de poder y el eterno retorno; a manera de conclusión, argumento que, sin perjuicio de la presencia de conceptos como “perspectivismo” o “muerte del sujeto”, la obra no tiene un fin deconstructivo, sino que consiste en una reflexión acerca de la plenitud y la decadencia de la condición humana.
Una ética de lo contingente: Judith Butler y el principio de la (no) violencia
Authors: Agüero Águila Javier
Published: December 2022

El siguiente trabajo se organiza en torno a una cuestión fundamental: la manera en que podría articularse una reflexión sobre lo ético y lo político si consideramos la violencia como vector central de lo ético-político mismo. En otras palabras, doy cuenta de cómo la violencia se estabiliza como el fenómeno principal al interior de la vida social produciendo la instalación de un cierto ethos en las sociedades contemporáneas. Llevo a cabo esta búsqueda a partir de los trabajos de la filósofa judíoestadounidense Judith Butler y del rescate de los aspectos éticopolíticos que se desprenden de su obra.
Intermittent water supply in Indian cities: considering the intermittency beyond demand and supply
Authors: Satpathy Suchismita , Jha Rohit
Published: December 2022

Intermittent water supply (IWS) is a typical characteristic of cities in developing countries like India. One of the factors responsible for IWS is unaccounted for water (UFW). Factors like increase in population, upward trends in water demand, water scarcity due to climate change, and asymmetric distribution of water resources are also equally important. However, social relations of water are poorly understood and camouflaged under technicalities associated with IWS. Thus, in this paper, we examine IWS in Indian mega cities and secondary cities with an ethno-economic framework by bringing the data together from various administrative sources like government agencies, allude to its parameters from logistical perspectives, e.g. distances, capacities, population strength, etc., and try to position the water issue with challenges associated with caste, class, gender, religion, region, and governance. The ethno-economic perspective is an attempt to not only complement but also supplement the scientific studies from other disciplines by understanding the real nature of demand and supply problems in urban water management. This paper demonstrates IWS as a multi-dimensional problem and stresses the human drivers of intermittency.
Repurposing of Chemotherapeutics to Combat COVID-19
Authors: Nandi Sisir , Nayak Bhabani Shankar , Khede Mayank Kumar , Saxena Anil Kumar
Published: December 2022

Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a novel strain of SARS coronavirus. The COVID-19 disease caused by this virus was declared a pandemic by the World Health Organization (WHO). SARS-CoV-2 mainly spreads through droplets sprayed by coughs or sneezes of the infected to a healthy person within the vicinity of 6 feet. It also spreads through asymptomatic carriers and has negative impact on the global economy, security and lives of people since 2019. Numerous lives have been lost to this viral infection; hence there is an emergen-cy to build up a potent measure to combat SARS-CoV-2. In view of the non-availability of any drugs or vaccines at the time of its eruption, the existing antivirals, antibacterials, antimalarials, mu-colytic agents and antipyretic paracetamol were used to treat the COVID-19 patients. Still there are no specific small molecule chemotherapeutics available to combat COVID-19 except for a few vac-cines approved for emergency use only. Thus, the repurposing of chemotherapeutics with the poten-tial to treat COVID-19 infected people is being used. The antiviral activity for COVID-19 and bio-chemical mechanisms of the repurposed drugs are being explored by the biological assay screening and structure-based in silico docking simulations. The present study describes the various US-FDA approved chemotherapeutics repositioned to combat COVID-19 along with their screening for bio-logical activity, pharmacokinetic and pharmacodynamic evaluation.
The Role of Nrf2 in Relieving Cerebral Ischemia-Reperfusion Injury
Authors: Sun Yu , Yang Xu , Xu Lijun , Jia Mengxiao , Zhang Limeng , Li Peng , Yang Pengfei
Published: December 2022

Ischemic stroke includes two related pathological damage processes: brain injury caused by
primary ischemia and secondary ischemia reperfusion (I/R) injury. I/R injury has become a worldwide
health problem. Unfortunately, there is still a lack of satisfactory drugs for ameliorating cerebral I/R
damage. Nrf2 is a vital endogenous antioxidant protein, which combines with Keap1 to maintain a
dormant state under physiological conditions. When pathological changes such as I/R occurs, Nrf2
dissociates from Keap1 and activates the expression of downstream antioxidant proteins to exert a protective
effect. Recent research have shown that the activated Nrf2 not only effectively inhibits oxidative
stress, but also performs the ability to repair the function of compromised mitochondria, alleviate
endoplasmic reticulum stress, eliminate inflammatory response, reduce blood-brain barrier permeability,
inhibit neuronal apoptosis, enhance the neural network remolding, thereby exerting significant protective
effects in alleviating the injuries caused by cell oxygen-glucose deprivation, or animal cerebral
I/R. However, no definite clinical application report demonstrated the efficacy of Nrf2 activators in the
treatment of cerebral I/R. Therefore, further efforts are needed to elaborate the role of Nrf2 activators
in the treatment of cerebral I/R. Here, we reviewed the possible mechanisms underlying its potential
pharmacological benefits in alleviating cerebral I/R injury, so as to provide a theoretical basis for
studying its mechanism and developing Nrf2 activators.
Substance use Specificities in Women with Psychosis: A Critical Review
Authors: Casanovas Francesc , Fonseca Francina , Mané Anna
Published: December 2022

Background:

Women with schizophrenia or other psychotic disorders differ from male patients
in many respects, including psychopathology, prognosis, disease course, and substance use
comorbidities. Most studies performed to date to investigate the association between drug use and
psychosis have not evaluated gender differences, although this has started to change in recent years.

Methods:

We briefly summarize the available evidence on gender differences in drug use and substance
use disorders (SUD) in psychotic patients during the early phases of the psychotic illness and
during the course of schizophrenia.

Results:

Substance use and SUD are both less prevalent in women, both in the general population and
at all phases of the psychotic spectrum. Some studies suggest that SUD may be under diagnosed in
female patients, in part due to their more vulnerable profile. Substance use, especially cannabis, may
more negatively impact females, especially on the disease course and prognosis. The available data
suggest that it may be more difficult to treat SUD in female patients with schizophrenia, which could
negatively impact prognosis.

Conclusion:

Women with concomitant psychotic illness and SUD comprise a highly vulnerable subgroup.
This should be considered when selecting the treatment approach, especially in the early phases
of the illness, to ensure better outcomes.
Combined Experimental and Theoretical Spectroscopic Properties (FT-IR, FT-Ra, Uv-Vis, and NMR), DFT Studies, Biological Activity, Molecular Docking, and Toxicity Investigations of 3-methoxy-1-piperazinylbenzene
Authors: Kucuk Ceyhun , Yurdakul Senay , Erdem Belgin
Published: December 2022

Background:

Piperazine and its derivatives have many important pharmacological properties such as antimicrobial, antituberculosis, anticancer, antiviral, and antimalarial activity, as well as HIV protease inhibitors and antidepressant activity. Therefore, the structural, spectroscopic, electronic, optic, and thermodynamic properties, and biological activity of the 3-methoxy-1- piperazinylbenzene molecule, which is a piperazine derivative, were investigated in this study.

Methods:

Theoretical calculations for ligands were carried out with the DFT method by using B3LYP /6-311++G(d,p) basis set except for NMR calculations. NMR analyses were calculated with 6-311++G(2d,p) and were recorded experimentally.

Results:

Experimental and calculated frequencies are compared and they are in agreement with each other. Also, the Uv-Vis absorbance spectrum for the title molecule was recorded and calculated. They were found to be in harmony with each other. According to the results of molecular orbital analysis and other quantum chemical properties, this molecule has low reactivity and stability. The reactive areas of the ligand were investigated by using MEP map, Fukui functions, and electronic charge analyses, and also performing ELF and LOL analysis. As a result of all these analysis methods, electrophilic regions of the molecule were found to be similar. Some thermodynamic properties at different temperatures and non-linear optical properties were investigated. The increase in enthalpy and entropy values depending on the temperature rise indicates that the thermodynamic structure of the molecule has changed. Also, this molecule has an important non-linear optical response.

Conclusion:

In biological activity and toxicity studies, the title molecule has an activity against microorganisms and a good drug score.
“Phardiacare” Program for Improved Medication Adherence and Clinical
Outcomes of Type 2 Diabetes Mellitus Patients in Community Health
Centers
Authors: Pradhyta Ferna Putri , Sartika Ratu Ayu Dewi , Sauriasari Rani
Published: December 2022

Background:

The role of pharmacists in middle-income countries such as Indonesia is
still not optimal. In this study, we developed a program called “Phardiacare”, a specific
pharmacist-led program for Type 2 diabetes mellitus (T2DM) patients.

Objective:

The objective of this study is to assess the effectiveness of the application of the
“Phardiacare” program in improving medication adherence and clinical outcomes in T2DM
patients.

Methods:

The study was quasi-experimental, with a pretest-posttest design, and was conducted
prospectively from July to October 2019 at the Matraman and Jatinegara District Health Center,
Jakarta, Indonesia. The study comprised 33 T2DM patients in an intervention group (IG) who
received the “Phardiacare” program and 33 patients in a control group (CG). Assessment was performed
of HbA1c, FBG, LDL, HDL, total cholesterol, triglycerides, and blood pressure.

Results:

HbA1c after intervention in the IG was lower than that of the CG (p <0.05). Intra-group
mean differences showed improvement in the clinical parameters of FBG, triglycerides, and
diastolic blood pressure in the IG (p <0.05), but not in the CG. Other clinical parameters did not
show significant improvement. The results of the multivariate analysis showed that the
“Phardiacare” program had a 16 times greater effect in reducing levels of HbA1c in the IG [95%
CI 3.995:67.113, p <0.001] compared to the CG, even after controlling for confounding variables.

Conclusion:

The “Phardiacare” program was effective in improving patient medication adherence
by decreasing HbA1c and FBG, but it did not have a significant effect on LDL, HDL, total
cholesterol, and systolic blood pressure. Therefore, the implementation of Phardiacare program in
the management of chronic diseases, especially T2DM, should be considered.
Cone Beam CT Features and Oral Radiologist’s Decision-making of
Arrested Pneumatization of the Sphenoid Sinus
Authors: Alsufyani Noura , Alsuayri Nouf , Alrasheed Raghad
Published: December 2022

Objectives:

To assess the demographic and radiographic features of arrested pneumatization of the sphenoid sinus (APS) and their influence on the confidence of oral and maxillofacial radiologists (OMFRs) in diagnosing APS.

Methods:

Reports of cone beam computed tomography (CBCT) APS were retrieved, and the demographic and radiographic features were retrospectively analyzed. Five OMFRs assessed the CBCT images and their confidence in diagnosing APS. The OMFRs’ experience (years), expertise (skull-base CBCT cases/month) and diagnostic confidence level were analyzed for agreement and associations with demographic or radiographic features.

Results:

Of 29 APS cases, 17 (58.6%) were women, and the mean age was 29.9±19 years. Twenty cases (69.0%) presented unilaterally, and 27 (93.1%) involved the sphenoid body. The most common accessory site was the pterygoid process (19, 65.5%). The vidian canal and foramen rotundum were involved in 27 (93.1%) and 17 (58.6%) cases, respectively. Most cases (28, 96.6%) were well-defined, corticated, and showed mixed attenuation. APS diagnostic confidence was higher among the expert OMFRs (72.4%–82.8% vs. 58.6%–62.1%).

Conclusion:

Radiographic features differentiating APS from skull-base tumors were shown on CBCT. The confidence of OMFRs with similar experience in years depended on their frequency of examining CBCT cases involving the skull base.
In silico-Based Structural Prediction, Molecular Docking and ADMET
Analysis of Novel Imidazo-Quinoline Derivatives as Pf Purine Nucleoside
Phosphorylase Inhibitors
Authors: Mallick Chaitali , Mishra Mitali , Asati Vivek , Kashaw Varsha , Das Ratnesh , Kashaw Sushil Kumar
Published: December 2022

Introduction:

The prolonged antimalarial therapy with the marketed drug has developed
multi-resistant strains of Plasmodium parasites that emerge as a consequential global problem.
Therefore, designing new antimalarial agents is an exclusive solution to overcome the alarming
situation.

Methods:

The integrated computational perspectives, such as pharmacophore mapping, 3D-QSAR
and docking studies have been applied to improve the activity of the imidazo-quinoline scaffold.
The best hypothesis AARRR_1 (Survival score 5.4609) obtained through pharmacophore mapping
revealed that imidazo-quinoline scaffold is found to be vital for antimalarial activity. The significant
CoMFA (q2 = 0.728, r2 = 0.909) and CoMSIA (q2 = 0.633, r2 = 0.729) models, developed by
using molecular field analysis with the PLS method, showed good predictive ability with r2
pred values
of 0.9127 and 0.7726, respectively. Docking studies were performed using Schrodinger and
GOLD software with the Plasmodium falciparum purine nucleoside phosphorylase enzyme (PDB
ID-5ZNC) and results indicated that the imidazo-quinoline moiety facilitates the interaction with
Tyr 160.

Results:

In addition, some compounds are screened from the ZINC database based on structural
requirements to verify the relevance of the research. Finally, designed molecules and ZINC database
compounds were screened through the ADMET tool to evaluate pharmacokinetic and druglikeness
parameters.

Conclusion:

Thus, these exhaustive studies suggested that established models have good predictability
and would help in the optimization of newly designed molecules that may lead to potent antimalarial
activity for getting rid of resistance issues.
Lignins and Lignans – Recent Developments and Trends Regarding their Pharmaceutical Properties
Authors: Zongo Luc , Lange Heiko
Published: December 2022

Lignins and lignans as natural polyphenols exhibit a rather broad variety of common physico-chemical features that can be of interest with respect to their use in the pharmaceutical sector. While polyphenol types have antioxidant, antiinflammatory, antibacterial and eventually antiviral activities in common, structural features beyond the polyphenol aspect differ enormously: isolated lignins are oligomers and/or polymers of monolignol C9-building blocks, while lignans are based on dimers thereof. The structural differences caused lignin to be exploited in the pharmaceutical sector mainly as material for the generation of matrices and carrier for drug delivery, while lignans are tested for the suitability as APIs. The chapter gives an overview of this situation, including the biological backgrounds of the two interesting natural polyphenols, isolation and methods for their characterisation.
Phenols and Polyphenols as Carbonic Anhydrase Inhibitors
Authors: Bonardi Alessandro , Supuran Claudiu T. , Nocentini Alessio
Published: December 2022

Thousands of phenolic derivatives have been identified in the plant kingdom, which exert crucial roles in plant physiology. Many such derivatives were shown to produce pharmacological effects in humans which address their use in medicine as antiaging, anti-inflammatory, antioxidant, antidiabetic, and antiproliferative agents among others. Numerous such pharmacological activities are likely to derive from the inhibition of human carbonic anhydrase (CAs, EC 4.2.1.1) isoforms. Phenols, in fact, are able to anchor to the zinc-bound nucleophile present in the enzyme active site, blocking the catalytic action of CAs in humans and/or encoded in various microorganisms. This chapter discusses natural, semisynthetic and synthetic phenol derivatives that exhibited a CA inhibitory action. The discussion over the CA inhibition profiles is categorized as the inhibition of human CAs and inhibition of CAs from microorganisms. Multiple types of inhibition mechanisms by phenolic derivatives are discussed according to X-ray crystallographic resolutions and in silico studies.
Knowledge Organization System and Post-Disciplinarity Climate Change and COVID-19 in the context of the 2030 Agenda
Authors: Ramos Marcos Gonçalves , Carvalho Priscila Ramos , Souza Rosali Fernandez de
Published: December 2022

The study was inspired by the theoretical approaches of Beghtol, Buckland, Kleinberg, and Hjørland to discuss knowledge representation on Climate Change and COVID-19 in the context of Agenda 2030. This exploratory research was based on bibliometric methodsthrough VOSviewer and CitNetexplorer tools to analyze the terms Climate Change and COVID-19, in the databases Scopus, Web of Science, and Dimensions, in the period 2019-2020. Approaches 7 and 8 of domain analysis were used to discuss the knowledge of disciplinarity and to identify the emergence of domains. Data collected from Brazil National Council for Scientific and Technological Development, in the Lattes Platform and Directory of Research Groups, were added for analysis purposes. The conclusion pointedout that Climate Change and COVID-19 can be considered emerging domains, suggesting a possible post-disciplinary model. The 2030 Agenda reinforces the importance of international cooperation and a commitment to exchange information on scientific communities and other communities that discuss sustainable solutions to global problems such as Climate Change and COVID-19.
Fasilitasi vaksinasi masyarakat marjinal
Authors: Tristanti Tristanti , Ahnaf Muhammad Dhiauddin
Published: December 2022

Fasilitasi dalam konteks ini bertujuan untuk membantu masyarakat agar lebih berdaya atau memiliki daya untuk melakukan seuatu serta memiliki kekuasaan untuk mengambil keputusan terhadap sesuatu yang berhubungan dengan kepentingan dan kebutuhannya. Fasilitasi vaksinasi bertujuan untuk mengembangkan kesadaran dalam bidang kesehatan khususnya dalam hal vaksinasi sebagai bentuk penanggulangan covid-19. Penelitian ini adalah penelitian Tindakan. Tindakan yang diberikan berupa fasilitasi vaksinasi. Fasilitator berperan sebagai mediator dan transporter. Metode pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Tindakan dalam bentuk fasilitasi vaksinasi dilaksanakan dalam tiga tahap yang terdiri dari tahap perencanaan, pelaksanaan dan evaluasi. Hasil pemberian Tindakan adalah mulai ada kesadaran yang terbangun pada masyarakat. Kesadaran yang terbangun dalam masyarakat adalah kesadaran untuk mengikuti vaksinasi sebagai Langkah awal untuk lebih berdaya dan memiliki daya dalam bidang kesehatan. Dari hasil dan evaluasi fasilitasi vaksinasi yang telah dilakukan, fasilitasi vaksinasi yang dilakukan cukup berhasil dan membawa manfaat untuk masyarakat marjinal di Kledokan.
Therapy dog in the rehabilitation of children with disabilities – opinions and expectations of parents and professionals
Authors: Karnjuš Renata , Schnurrer-Luke-Vrbanić Tea , Tumpa Tambić Jasmina , Šarić Katarina , Bodul Marina , Brenčić Cindrić Mirjam
Published: December 2022

Cilj: Cilj je ovoga istraživanja ispitati mišljenja i očekivanja roditelja i stručnih osoba koje sudjeluju u rehabilitaciji djece o primjeni terapijskog psa u rehabilitaciji djece s teškoćama u razvoju, o utjecaju na motiviranost, psihički, socijalni i motorički razvojni aspekt. Ispitanici i metode: Istraživanje je obuhvatilo 133 ispitanika podijeljena u dvije skupine: skupina roditelja djece s teškoćama u razvoju (n = 53) i skupina stručnjaka koji sudjeluju u procesu rehabilitacije djece s teškoćama u razvoju (n = 80). Anketni upitnici izrađeni su u elektroničkom obliku, na internetskoj online platformi i sadržavali su tvrdnje na koje su ispitanici odgovarali pomoću Likertove ljestvice (1 – u potpunosti se ne slažem; 5 – u potpunosti se slažem). Rezultati: Roditelji (x = 4,64 ± sd = 0,71), kao i stručnjaci (x = 4,75 ± sd = 0,70), slažu se da terapijski pas može pomoći motivirati dijete u rehabilitaciji. Ispitanici smatraju da bi terapijski pas mogao pomoći i utjecati u više razvojnih aspekata kod djece s teškoćama u razvoju: na psihički razvoj djeteta (roditelji x = 4,7 ± sd = 0,57; stručnjaci x = 4,7 ± sd = 0,72), na razvoj socijalnih vještina (roditelji x = 4,58 ± sd = 0,63; stručnjaci x = 4,67 ± sd = 0,74) te na razvoj motoričkih vještina (roditelji x = 4,45 ± sd = 0,82; stručnjaci x = 4,7 ± sd = 0,7). Roditelji djece s teškoćama u razvoju (x = 4,89 ± sd = 0,37), kao i stručnjaci (x = 4,79 ± sd = 0,61), smatraju da je poželjno razvijati i širiti terapijski pristup sa psom. Zaključak: Iz svega se može zaključiti kako u Republici Hrvatskoj roditelji djece s teškoćama u razvoju, jednako kao i stručnjaci, imaju pozitivno mišljenje i optimistično orijentirana očekivanja prema uvođenju terapijskog psa u rehabilitaciju.
Aves rapaces nocturnas en cautiverio: estudio en búho Ciccaba virgata (Strigidae)
Authors: Hernández-Lozano Alberto , López de Buen Lorena , Ahuja-Aguirre Concepción del Carmen , Paredes-Ramos Pedro , Juanz-Aguirre Diana Gissell
Published: December 2022

Objective. To observe the behavior, hormonal patterns, and welfare in captive mottled owl Ciccaba virgata (Strigidae). Materials and methods. The study was conducted at environmental management units (UMA) in Xalapa, Mexico, on six owls (two females in one enclosure, one male and one female in another, both without public display and with environmental enrichment, and two isolated individuals, kept caged or perched, with daytime public display). Behaviors were monitored in each pair or individual during 120 hours of filming (60 h during the day and 60 h at night). Concentrations of fecal metabolites of corticosterone, estradiol, and progesterone were measured, and welfare was assessed with observational indicators and surveys. Results. The paired owls showed normal behaviors and excellent welfare (95.5%), while the isolated individuals showed undesirable behaviors and regular welfare (51.4%). Of 24 behaviors considered in an ethogram, 11 were observed repeatedly in all specimens. The isolated birds had higher agonistic, feeding, and individual activity (p<0.001) than the paired birds, although it did not result in lower levels of corticosterone (p=0.09) nor estrogens (p=0.29) in females, only in progesterone (p=0.001). Conclusions. In captive mottled owls, daytime display and inadequate facilities promote the presence of undesirable behaviors that can affect their welfare. Therefore, the use of enrichment measures, such as larger enclosures, feeding at night, and pair housing (female and male, or two females) should be considered to reduce the negative effects of captivity and increase their welfare.
Bacterial adhesion of Streptococcus mutans to cobalt chromium recast alloys
Authors: Sulistiani Dewi Arsih , Widjijono Widjijono , Dharmastiti Rini
Published: December 2022

Cobalt chromium (CoCr) alloys are utilized to make dental prosthesis. Casting CoCr alloys is a common operation in dentistry laboratories due to its low cost. Casting surplus (metal remaining in the sprue and crucible former) is frequently reused by dental laboratories to reduce and recycle metal waste. However, the quality and safety of these recast alloys require further information. Microbial attachment to the surface of metal prostheses may affect its quality and safety. Biofilm formation on metal surface can cause biocorrosion and secondary infection. The effects of different proportions of recast Cobalt Chromium alloy on the bacterial adhesion are not clear. The purpose of this study was to investigate how recasting affects the Streptococcus mutans (S. mutans) adhesion. Twenty disk-shaped specimens (n= 20, allocated for 5 groups) were prepared from CoCr alloys (Remanium GM; Dentaurum) with different proportions (100% new alloy, 25% recast alloy, 50% recast alloy, 75% recast alloy, and 100% recast alloy). After the immersion of the specimens in bacterial suspension for 24 hours, the number of bacteria that adhere to the specimen’s surface was counted using Colony Forming Units. Data were analyzed with one-way ANOVA (α = 0.05). The bacterial adhesion was significantly affected by the recast alloys (p < 0.05). An increased proportion of CoCr recast alloys showed an increase in S. mutans adhesion to the specimen surface.
Comparison of apical sealing ability between bioceramic and zinc oxide eugenol-based sealer during root canal treatment, in vitro
Authors: Mahendra Dedy Agoes , Nindita Yora , Wibowo Gustantyo Wahyu , Fortuna Gloria
Published: December 2022

Obturation with a sealer material that provides an adequate apical sealing ability is required to prevent endodontic treatment failure due to microleakage. However, there are no sealers that meet all the physical and chemical properties to be able to hermetically seal the root canal system to date. Various sealer materials have been developed in recent years including the use of bioceramic materials which are claimed to have excellent biocompatibility to tissues. This study aimed to compare the apical sealing ability of bioceramic-based and zinc oxide eugenol (ZOE)-based sealer in root canal treatment. A total of 27 extracted mandibular premolars were decoronated to the standard root length of 14 mm. The root canals were prepared with a crown-down technique using manual instrument to file F3 (30/.09). The samples were then divided into three groups: obturation with bioceramic-based sealer (n=9); ZOE-based sealer (n=9); and control group (n=9). Microleakage was measured using a dye penetration method with 1% methylene blue and observed under stereomicroscope at x20 magnification. The mean of the maximum penetration length from the lowest to the highest was found in the bioceramic-based sealer group (0.825 mm), the ZOE-based sealer group (3.850 mm), and the control group (4.444 mm). One-way ANOVA test showed a significant difference in the maximum penetration length between the three groups (p<0.05). The post hoc LSD test showed a significant difference in the maximum penetration length between the bioceramic-based and ZOE-based sealer groups (p<0.001). Obturation with bioceramic-based sealer provides a better apical sealing ability than that with ZOE-based sealer.
Nickel ion release of niti archwire in variations of immersion time and toothpaste
Authors: Cahayati Syamsiar , Batubara Lusiana , Purbaningrum Diah Ajeng , Wibowo Budi
Published: December 2022

Nickel-titanium archwires in orthodontic wires have nickel ion releases. The use toothpaste and saliva immersion time may cause its releases. This study aims to prove the difference and interaction between immersion time and toothpaste variations towards the amount of nickel ion releases at nickel-titanium archwires. The study was an experimental research with a post-test only control group design. Twenty seven nickel-titanium archwires were divided into three groups, i.e., K group, which were immersed in artificial saliva. P1 was immersed in artificial saliva and 1.5 gram of toothpaste A, and P2 was immersed in artificial saliva, and 1.5 gram of toothpaste B. The samples were incubated (37 °C) for 1 and 1.5 months. Nickel ion released was analyzed using SSA. Two Way ANOVA and Post Hoc LSD test were the statistic test used. The results of this study were the K group which released 0.112 mg/l and 0.685 mg/l, P1 which released 0.093 mg/l and 0.670 mg/l, and P2 which released 0.099 mg/l and 0.657 mg/l. There were differences in toothpaste variations (p = 0.029), differences in immersion time (p = 0.000) and there was no interaction between immersion time and toothpaste variations (p = 0.505) on the amount of nickel ion release. There was a significant difference in K-P1 (p = 0.038), K-P2 (p = 0.013), P1-P2 (p = 0.049). There was a difference in immersion time and toothpaste variation, but there was no interaction between immersion time and toothpaste variation towards the amount of nickel ion releases.
Effect of two different materials in sealing vertical root fractures of intentional replantation on epithelial thickness of periradicular tissue
Authors: Untara Raphael Tri Endra , Widjijono Widjijono , Asmara Widya , Ratih Diatri Nari
Published: December 2022

Vertical root fractures of intentional replantation need a material capable of binding the fragments of the fracture line tightly and encouraging the regeneration of periradicular tissue. One of the indicators that regeneration of periradicular tissue takes place is epithelial thickness. This study aimed to investigate the effect of mineral trioxide aggregate (MTA) and self-adhesive resin cement as the adhesive materials in sealing vertical root fractures of intentional replantation on the epithelial thickness of periradicular tissue. This study used 27 male New Zealand rabbits with the age range of 8-12 weeks. The mandibular incisor was extracted, and the tooth was cut from the cervical border to the 2/3 apical third. The samples were assigned randomly into three groups of 9 each, namely Group 1 with no application of any material in the fracture line (control group), Group 2 with MTA, and Group 3 with self-adhesive resin cement. All the teeth in all the groups were then inserted back into the socket. Each group was further divided into three subgroups based on the observation time, namely days 7, 14, and 21. Histological observations of the epithelial thickness were carried out under the light microscope (400x magnification). Data were analyzed using a two-way ANOVA and LSD post hoc test with a confidence level of 95%. The two-way ANOVA analysis showed that the materials used for sealing the fracture lines had a significant effect on the epithelial thickness (p<0.05), while the observation time did not affect the epithelial thickness (p>0.05). No interaction occurred between the material used and observation times (p>0.05). It can be concluded that MTA generated a greater epithelial thickness of periradicular tissue compared than self-adhesive resin cement in sealing vertical root fractures of intentional replantation.