bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular profile reveals immune-associated markers of medulloblastoma for different subtypes
Authors: li shenglan , Kang Zhuang , Chen jinyi , Wang Can , Cai Zehao , Pan Leixin , Chen Feng , Li Wenbin
Published: November 2021

Background

Medulloblastoma is a common intracranial tumor among children. In recent years, research on cancer genome has established four distinct subtypes of medulloblastoma: WNT, SHH, Group3, and Group4. Each subtype has its own transcriptional profile, methylation changes, and different clinical outcomes. Treatment and prognosis also vary depending on the subtype.
Methods

Based on the methylation data of medulloblastoma samples, methylCIBERSORT was used to evaluate the level of immune cell infiltration in medulloblastoma samples and identified 10 kinds of immune cells with different subtypes. Combined with the immune database, 293 Imm-DEGs were screened. Imm-DEGs were used to construct the co-expression network, and the key modules related to the level of differential immune cell infiltration were identified. Three immune hub genes (GAB1, ABL1, CXCR4) were identified according to the gene connectivity and the correlation with phenotype in the key modules, as well as the PPI network involved in the genes in the modules.
Results

The subtype marker was recognized according to the immune hub, and the subtype marker was verified in the external data set, the methylation level of immune hub gene among different subtypes was compared and analyzed, at the same time, tissue microarray was used for immunohistochemical verification, and a multi-factor regulatory network of hub gene was constructed.
Conclusions

Identifying subtype marker is helpful to accurately identify the subtypes of medulloblastoma patients, and can accurately evaluate the treatment and prognosis, so as to improve the overall survival of patients.
Manufacturability and Surface Characterisation of Polymeric Microfluidic Devices for Bio-medical Applications
Authors: Arcot Yugandhar , G.L Samuel , Kong Lingxue
Published: November 2021

Microfluidic devices fabricated through mechanical micromachining techniques have already been reported to be highly economical when compared to other techniques. Direct mechanical machining processes are generally classified as a one-step manufacturing process, having the advantages of rapid prototyping and batch production. Though there are advancements in ultra-precision machining techniques, the real challenge of direct machining polymeric microfluidic channels is the occurrence of poor surface integrity owing to the change in mechanical as well as viscoelastic properties. This forms the key objective of the present research work, where the major emphasis has been given to understand the applicability of micro-milling techniques in fabricating microfluidic devices, especially for bio-applications. In this research, the mechanical micro-milling technique was used to create microscale channels on polymethylmethacrylate (PMMA) and polycarbonate (PC) materials; wherein the process capability was mainly assessed based on the surface characteristics of the micro features. Furthermore, for the quantitative analysis, a comparative study was also performed by measuring the surfaces roughness and surface energy of the microchannels made by various fabrication routes such as hot embossing and lithography. The experimental results indicate that the micro-milling of PMMA is the preferable choice for fabricating microfluidic devices when compared to PC. Also, for showing the manufacturability of the mechanical micromachining technique, microfluidic channels with serpentine channels were machined with a depth and width of 50µm and 200µm respectively. The applicability of the fabricated microfluidic devices was further validated by evaluating the functioning of these devices for blood cell separation at different dilution rates.
Comparison of the Efficacy and Safety of Non-Steroidal Anti-Inflammatory Drugs and Corticosteroid Drugs for Prevention of Cystoid Macular Edema After Cataract Surgery: A Systematic Review and Network Meta-Analysis
Authors: Li Shanshan , Wang Hui-Hui , Zhang Da-Wei
Published: November 2021

Introduction:

To compare the efficacy and safety of non-steroidal anti-inflammatory drugs (NSAID), corticosteroid (CS), and a combination of both drugs to prevent cystoid macular edema (CME) after cataract surgery.
Methods

We searched Pubmed, Cochrane Library, and Embase electronic databases to assess the relevant randomized controlled trials (RCTs) up to 28 April 2021. Network meta-analysis was registered on PROSPERO (CRD42020182520).
Results

Twenty-four RCTs were included in this review. The NSAID and combination of both drugs were significantly reduced the risk of developing CME than CS alone in non-diabetics and mix population. In the ranking profiles, the combination therapy showed a significant advantage over the single drugs and was less likely to develop CME. Diclofenac was the most likely to reduce the odds of developing CME compared with bromfenac and nepafenac. Dexamethasone was the most likely to reduce the odds of developing CME compared with betamethasone and fluorometholone.
Conclusion

NSAID combination with CS has significantly reduced the risk of developing CME postoperatively than the single drug. Diclofenac was superior to bromfenac and nepafenac in preventing CME. Dexamethasone was superior to betamethasone and fluorometholone in preventing CME.
miR-1275 Targets MDK/AKT Signaling to Inhibit Breast Cancer Chemoresistance by Lessening the Properties of Cancer Stem Cells
Authors: Han Xu , Ma Ge , Wang Xinyang , Fu Jingyue , Wang Jingyi , Xu Jin , Li Minghui , Xia Tiansong , Wang Shui
Published: November 2021

Background: Chemoresistance is a major obstacle in the neoadjuvant chemotherapy (NCT) of locally advanced breast cancer (LABC). Identification of miRNAs as prognostic biomarkers may help overcome chemoresistance of breast cancer (BC). The aim of this study was to evaluate the expression level of miR-1275 in plasma samples and the biological functions in the chemoresistance of BC.Methods: The expression levels of miR-1275 in plasma samples and cells were measured by RT-qPCR. The associations between the expression levels of miR-1275 and clinicopathological features were studied. CRISPR/Cas9-mediated gene editing was used to construct miR-1275 knock-out cells. CCK-8, colony formation assays, epirubicin accumulation assay and xenograft tumor models were used to detect the sensitivity of breast cancer cells to epirubicin in vitro and in vivo. Mammosphere formation assay, flow cytometry analysis and western blot analyses were used to evaluate the effects of miR-1275 on cancer stem cells (CSCs) characteristics in BC cells. Dual-luciferase reporter, RNA pulldown, ELISA and IHC were used to verify the relationship between the expression of miR-1275 and Midkine (MDK). Results: We found that miR-1275 was significantly downregulated in plasma from patients resistant to chemotherapy with LABC and in chemoresistant breast cancer cell lines, while patients with low levels of miR-1275 show poor overall survival. Mir-1275 knock-out promoted chemoresistance in breast cancer cells by increasing the properties of cancer stem cells in vitro and in vivo. Mechanistically, we identified that Midkine was determined to be direct downstream protein of miR-1275 which initiated PI3K/Akt signaling in breast cancer cells.Conclusions: We demonstrated that the high expression level of miR-1275 in plasma predicted better response to NCT. The reduction of miR-1275 promoted BC cells chemoresistance by increasing CSC properties via targeting MDK/AKT axis. The potential of miR-1275 as a new prognostic biomarker and therapeutic target of breast cancer patients was identified.
Learning and Visualizing Chronic Latent Representations Using Electronic Health Records
Authors: Chushig-Muzo David , Soguero-Ruiz Cristina , Bohoyo Pablo de Miguel , Mora-Jiménez Inmaculada
Published: November 2021

Background: Nowadays, patients with chronic diseases such as diabetes and hypertension have reached alarming numbers worldwide. These diseases increase the risk of developing acute complications and involve a substantial economic burden and demand for health resources. The widespread adoption of Electronic Health Records (EHRs) is opening great opportunities for supporting decision-making. Nevertheless, data extracted from EHRs are complex (heterogeneous, high-dimensional and usually noisy), hampering the knowledge extraction with conventional approaches. Methods: We propose the use of the Denoising Autoencoder (DAE), a Machine Learning (ML) technique allowing to transform high-dimensional data into latent representations (LRs), thus addressing the main challenges with clinical data. We explore in this work how the combination of LRs with a visualization method can be used to map the patient data in a two-dimensional space, gaining knowledge about the distribution of patients with different chronic conditions. Furthermore, this representation can be also used to characterize the patient's health status evolution, which is of paramount importance in the clinical setting. Results: To obtain clinical LRs, we considered real-world data extracted from EHRs linked to the University Hospital of Fuenlabrada in Spain. Experimental results showed the great potential of DAEs to identify patients with clinical patterns linked to hypertension, diabetes and multimorbidity. The procedure allowed us to find patients with the same main chronic disease but different clinical characteristics. Thus, we identified two kinds of diabetic patients with differences in their drug therapy (insulin and non-insulin dependant), and also a group of women affected by hypertension and gestational diabetes. We also present a proof of concept for mapping the health status evolution of synthetic patients when considering the most significant diagnoses and drugs associated with chronic patients. Conclusions: Our results highlighted the value of ML techniques to extract clinical knowledge, supporting the identification of patients with certain chronic conditions. Furthermore, the patient's health status progression on the two-dimensional space might be used as a tool for clinicians aiming to characterize health conditions and identify their more relevant clinical codes.
Production of Silk Fibroin Membrane for Heavy Metal Removal in Water
Authors: Sudsandee Suntorn , Dokmaingam Pannipha , Mingkhwan Rachaneekorn , Kiangkoo Nuttapohn , Worakhunpiset Suwalee , Boonying Patharawadee , Hu Chien-Chieh , Laohaprapanon Sawanya
Published: November 2021

Thermodynamically driven salts and annealing processes developed the pure silk fibroin (SF) membranes from Bombyx mori cocoons. For more generation, the silk fibroin solution 5 wt% mixed the sodium chloride (NaCl) and polyethylene glycol (PEG). The top surface and cross-section of silk fibroin mixed with NaCl (SF/NaCl) showed pore in the surface membrane and hydrophilic property. The β-sheet content in the SF/NaCl membrane is higher than pure silk fibroin (SF) and the silk fibroin mixed with PEG (SF/PEG) membranes. Then cadmium (Cd), lead (Pb), and mercury (Hg) metals in water filtered pass through only SF/NaCl experimented. The pressure, pH, and temperature were effect by the flow rate efficiency of SF/NaCl membranes. The results showed that the highest % removal of Cd, Pb, and Hg were 45.36%, 61.43%, and 86.87%, respectively. The best condition of absorption capacity was 8.50, 6.42, and 41.14 mg/g for Cd, Pb, and Hg. As a natural biopolymer, SF/NaCl possibly apply for Hg removal for water treatment, its nontoxicity, excellent biocompatibility, and mechanical toughness.
Effect of Bagasse Fiber As the Renewable Environmentally Friendly Material on the Properties of the Waterborne Intumescent Fireproof Coating
Authors: Zhan Wang , Ma Zhongfei , Sun Zhihao , Li Lixia , Gu Zhaozhan , Chen Le , Jiang Juncheng , Chen Zhiquan
Published: November 2021

Bagasse was applied as fire-retardant filler to prepare the waterborne intumescent fireproof coating. The effect of bagasse on the properties of the fireproof coating was investigated by fire protection test, thermogravimetric (TG), scanning electron microscope (SEM), energy dispersive spectrometer (EDS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), water resistance test and mechanical properties test. The result demonstrated the coating contained 1.5wt.% bagasse performed best in fire protection, thermal stability, oxidation resistance. Moreover, the char layer was dense and continuous. However, the fireproof coating contained 2 wt.% bagasse had excellent performance in water resistance test and mechanical properties test due to its properties of fiber. In addition, the components and chemical structure of char layer were characterized to study the flame retardant mechanism of bagasse in the fireproof coating.
Identification of two QTLs, BPH41 and BPH42, and their respective gene candidates for brown planthopper resistance in rice by a combinatorial approach of QTL mapping and RNA-seq
Authors: Tan Han Qi , Palyam Sreekanth , Gouda Jagadeesha , Kumar Prakash , Chellian Santhosh Kumar
Published: November 2021

The brown planthopper (BPH) is the leading cause of insect damage to rice plants. It has caused profound losses in rice production since the late 1970’s and continues to be a major pest problem. Therefore, there is an urgent need to discover new BPH resistance genes to ensure the successful production of rice. Here, a new BPH resistance source provided by SeedWorks International Pvt. Ltd., SWD10, was used for this purpose. A total of 232 F2 progenies were genotyped with 216 polymorphic markers. Results revealed two dominant QTLs located on the short and long arms of chromosome 4. These QTLs are referred to as BPH41 and BPH42, respectively. BPH resistance mechanism test revealed that antibiosis and antixenosis mechanisms both play a role in BPH resistance conferred by these two QTLs. To further reduce the size of each QTL, 14,368 recombinant lines were screened, and the QTLs were delimited between markers SWRm_01617 and SWRm_01522 for BPH41, and SWRm_01695 and SWRm_00328 for BPH42. Additionally, using RNA-seq data of lines containing the QTLs, we further shortlisted four and three gene candidates for BPH41 and BPH42, respectively. Differential gene expression analysis of lines containing the QTLs suggested that SWD10 BPH resistance is contributed by the plant’s innate immunity and the candidate genes may be part of the rice innate immunity pathway. The newly identified QTLs are currently being utilized for breeding BPH resistant rice varieties and hybrids.
Characterizing Diversity Based on Phenotypes and Molecular Marker Analyses of Purple Yam (Dioscorea Alata) Germplasm in Southern China
Authors: Chen Xin , Sun Jingyu , Zhu Qianglong , Xiao Yao , Zhang Hongyu , Huang Yingjin , Wang Putao , Cao Tianxu , Hu Rui , Xiang Zijin , Shan Nan , ZHOU Qinghong
Published: November 2021

Purple yam (Dioscorea alata L.), which is widely distributed in southern China, is characterized by great purple to red flesh or skin, as well as nutritional and medical values. However, their intraspecific genetic diversity remains unknown, which inhibits the germplasm innovation and variety protection of purple yams. In this study, genetic diversity of 26 landraces from southern China were carried out by using 17 morphological traits and 9 simple sequence repeat (SSR) markers, respectively. Results of phenotypic traits showed that all the accessions were divided into four groups at the euclidean distance of 1.43, and there is high correlation between the taxa and the regional distribution of yam accessions. The group IV includes the most accessions mainly from Jiangxi province, followed by group III, which contained accessions mostly from Fujian province. In addition, the leaf shape, leaf vein color and tuber flesh color, displayed higher Shannon's diversity index (I) and variation coefficient, which could identify the purple yam resources effectively. Based on the SSR markers analysis, the euclidean distance among all germplasms ranged from 0.17 to 0.79, and the 26 landraces were also clearly separated into four clusters at the euclidean distance of 0.49. Clustering results based on SSR markers and phenotypic traits were consistent roughly. Furthermore, population structure revealed the existence of three sub-populations in all accessions. These results demonstrate the genetic diversity and distinctness among the purple yam from southern China and provide a theoretical basis for the identification and utilization of purple yams.
Longitudinal Changes in The Association Between Coffee Intake and Ischaemic Heart Disease From 1990 to 2018: An International Ecological Study
Authors: SHIRAI Yoshiro , IMAI Tomoko , SEZAKI Ayako , MIYAMOTO Keiko , KAWASE Fumiya , ABE Chisato , SANADA Masayo , INDEN Ayaka , KATO Takumi , SUZUKI-SUGIHARA Norie , SHIMOKATA Hiroshi
Published: November 2021

In previous observational studies, the association between coffee consumption and the risk of cardiovascular disease has reversed from positive to negative over time. This long-term international ecological study examined whether the association between coffee intake and the mortality and incidence rates of ischaemic heart disease (IHD) changed between 1990 and 2018. We obtained data on coffee intake per capita (cups per day) and IHD mortality and incidence per 100,000 population, and socioeconomic and lifestyle indicators for each country from various publicly available databases. We integrated and analysed data from 147 countries with populations of ≥1 million. We employed a linear mixed model analysis to assess the interaction among coffee intake, IHD mortality and incidence rates by year. The random effects in the mixed model were the intercept and slope by year for each country. The mean global coffee intake increased (p<0.001), while IHD mortality (p<0.001) and incidence (p=0.073) decreased. In all models, the interaction between coffee intake and year showed a significant inverse association for IHD mortality and incidence rates (p<0.001 for all). The country-level association between coffee intake and IHD mortality and incidence rates was stronger in the negative direction between 1990 and 2018.
About modern terrorist activities in cyber space
Authors: Radu Moinescu
Published: November 2021

Cyber space has become a vital element for terrorist entities because of the multitude of opportunities that it offers. The article presents an evolution of the use of cyber space for terrorist purposes, from advertising and propaganda platform, to recruiting, influencing or intimidation platform, and even to the development of specialized software for encrypted communications and the possibility in development of cyber threats.
Productive strategies for development of specific mathematical competences for numbers and operation with them in the primary school
Authors: M P Temnikova
Published: November 2021

The application of productive strategies in education in mathematics facilitates development of specific mathematical competences in the Grade 1-4 students regarding natural numbers and operation with them. Subject of this article is presentation of the concepts about: competences, specific objective mathematical competences and the options for their development in and through education in mathematics in Primary School. A methodology system for work both with productive strategies, approaches, methods and with reproductive such strategies was created. This system is currently being applied in the educational process in mathematics. During the experimental work a longitudinal quality and quantity research of the above topics was performed. The conclusions of the research was that as a result of the experimental work the percentage of the students who made mistakes in writing down and comparing natural numbers decreased. The same can be said for the students who made mistakes during the arithmetical operations addition, subtraction, multiplication and division as well as mistakes in finding unknown component in a concrete equation. It was confirmed that as a result of the experimental work the specific mathematical competences related to the area of competency “Numbers” were developed in the primary school students in their completeness.
Increase the performance in women soccer players by using autogen training and sugestiv technics
Authors: D V Gidu
Published: November 2021

Objective: The purpose of this study was to examine the relationship between autogen training and sugetiv technic and the performances of women soccer players (both, psychological and physical performances). Research Methods and Procedures: In this study were participated 20 women soccer players from Selena SN Constanta team. The psychological abilities such as distributivity and concentration of attention, choise reaction times and the level of motivation was measured by standardised tests. The physical abilities was considered the precision of receiving, passing and shooting the ball. Results: The analysis of the data show that the experimental group obtained significant performances than control group (p < 0,05), with one exception – the values of choise reaction times. Discussion and Conclusions: The results confirm that the autogen training and sugestiv technic had positive effects regarding concentration and distributivity of attention and motivation of the subjects.
Water absorption behavior of reinforced epoxy laminates
Authors: Cristian Munteniţă
Published: November 2021

In this work, the studied materials are formed with a graduated matrix and reinforced with different types of fabrics. These composites are similar regarding the reinforcement, but the difference between them consists of the epoxy matrix types. Any application of a polymer composite in an outdoor environment invariably involves water absorption and variable thermal conditions. The degradation of composite materials was observed after each cycle, water absorption and frozenunfrozen, from a qualitative (visual) point of view, until the materials reached a saturation degree (the mass of specimens remaining constant after a certain number of cycles). This aspect had led to the conclusion that materials can no longer undergo quantitative changes. The aim of this work is to examine the behavior of materials subjected to environments that simulate atmospheric conditions (water absorption and frozen-unfrozen). The purpose of these materials was to be used in order to form some spare parts of vehicles such as, in case of an impact, to ensure pedestrians protection since they could have controllable strength. This aspect pays a very important role both in economically and environmental terms.
Consideration on amorphic metals
Authors: A. Chioibas
Published: November 2021

Generally, following the rapid cooling of a molten metal, it reaches amorphous state, which is characterized by a disordered particle distribution. The structure of liquids is described by quasicrystalline theory. It considers that in a chemically and topographically restricted area, an amorphous metal is characterized by an ordered arrangement of the molten metal particles and is called a cluster (local order domain). Those alloys that have the high capacity to become amorphous, according to the positional criteria of the components in the periodic table of the elements, are analyzed.
Respiratory support in COVID-19 patients in Kommunarka hospital: a single-centered, retrospective study
Authors: Matiushkov Nikita S. , Tyurin I. N. , Avdeikin S. N. , Boyarkov A. V. , Kazakov D. N. , Kostin D. M. , Srednyakov A. V. , Protsenko D. N.
Published: November 2021

Introduction. During the SARS-CoV-2 pandemic, worldwide healthcare system faced a new, insufficiently investigated, fast-spreading disease with multisystem failure and relatively high amount of severe diseased. Existing evidence base needs to be frequently revisited after data accumulation and analysis. Experience of dedicated COVID-19 centers should be summarized and implicated in clinical practice according to evidence-based principles, extensive clinical trial initiation. Objectives. To investigate baseline characteristics and treatment outcomes of patients with severe SARS-CoV-2 infection course, requiring respiratory support in the critical care settings of dedicated hospital. Materials and methods. In single-center retrospective study retrospective data collection of 451 respiratory support for COVID-19 related acute respiratory distress syndrome cases (noninvasive ventilation, mechanical ventilation) in intensive care unit patients for a 5-month period performed. The analysis aimed on demographic, clinical data, disease severity scores, respiratory support parameters and modality, continuous renal replacement therapy utilization and interleukin-6 receptor blockers administration, survival rates. Results. Respiratory support required 48.8 % of intensive care unit patients, the population was demographically balanced, Charlson Comorbidity Index was 4.46 ± 2.6 and was higher in the mechanically ventilated group. 30-day survival rate (all respiratory support cases) was 33.7 %, mortality structure analysis performed. The disease severity scores, respiratory mechanics among patients in dependence of respiratory support mode and during the period of case registration analysed as well. Median static respiratory compliance at the point of initiation of invasive mechanically ventilation was 43 (IQR 35–51). Mortality in the volume controlled mechanically ventilated group was higher. Conclusions. The patients, requiring respiratory support, during intensive care unit stay have high comorbidity levels. Indications for non-invasive ventilation may be extended on patients with lower Charlson index and initial SOFA score, however, early recognition of high risk of noninvasive ventilation failure required. Volume control invasive ventilation associated with higher mortality levels despite comparable disease severity scores. Further investigation required.
Criminal cases against doctors — anesthesiologists-reseanimators under articles: 109, 118, 238, 290, 293 of the criminal code of the Russian Federation: observational study
Authors: Gorbachev Vladimir I. , Netesin E. S. , Gorbacheva S. M. , Sumin S. A. , Utkin N. N.
Published: November 2021

Introduction. In the past few years, there has been a steady increase in citizens’ appeals to law enforcement agencies regarding inadequate and unsatisfactory medical care, which has led to an increase in the number of criminal cases brought against anesthesiologists-resuscitators. Objectives. Conduct an analysis of criminal cases against anesthesiologists-resuscitators initiated under Articles 109, 118, 238, 290 and 293 of the Criminal Code of the Russian Federation over the past 5 years. Materials and methods. In observational study performed analysis of court decisions on various articles of the Criminal Code of the Russian Federation against anesthesiologists-resuscitators for the period from January 2016 to December 2020, available in open databases. Results. The most significant and frequently committed defects in the provision of medical care related to the manipulations carried out, the main types of punishments under the presented articles are determined. The most illustrative examples from court decisions on criminal cases against anesthesiologists-resuscitators are given. Conclusions. Certain proposals were made on the procedure for conducting a forensic medical examination and conducting court records in relation to medical workers.
Diagnosis of competencies in the meetings industry in Poland, Hungary and Ireland in post-COVID-19 period
Authors: Walas Bartłomiej , Nocoń Marek , Nemethy Sandor , Petrovič František , Oleksa-Kaźmierczak Anna
Published: November 2021

The freezing of economies due to the COVID-19 pandemic caused damage not only on the sales side but also on the labor market due to the outflow of staff from companies specializing in the organization of meetings. The return of the meetings industry sector to the development path will involve skillful change management, including in the area of competencies and skills. To inventory and assess the competencies of employees in the meetings industry, this study was carried out among specialized enterprises in the meetings industry in Poland, Hungary, and Ireland, on samples of two research groups, i.e. the Director General (CEO) and operational employees based on questionnaires and individual in-depth interviews (IDI). The obtained results allowed to establish the hierarchy of self-assessment of own managerial competencies, assessment of the competencies of the CEO by the employees, areas of increasing team competencies, and areas of staff development in the sector shortly, contributing to the recovery from the pandemic crisis. Raising the competencies and qualifications of employees is perceived as one of the most powerful tools for overcoming the pandemic crisis, obtaining 68% positive indications among CEOs in Poland, 77% indications in Hungary, and 84% in Ireland. In all analyzed countries, the meetings industry is indicated as a strategic product of the tourist market. Among the planned long-term actions aimed at overcoming the pandemic crisis, increasing employee competencies is perceived as an opportunity for the companies operating the meetings industry sector (90% in Poland, and 80% in Hungary and Ireland).
AcknowledgmentThis study was done in frames of the project “Vocational competences in MICE sector” co-financed in frames of European Union program Erasmus + as part of the program The Dialog for Transformation, Erasmus+, 2020–2021.
The Impacts of Globalization on Human Resource Development Management
Authors: Gunawan Ali , Kurnia Stephen Gregorius , Ghazali Hasan
Published: November 2021

The terms “Globalization” and “The Digital Era” are familiar words that sound in our ears which mean progress or development.  The term globalization is a term that has links to increase interdependence among nations and people around the world through trade, investment, travel, popular culture and other forms of interaction so that the boundaries of a country become biased.  Globalization can bring about changes in all areas such as culture, economy, social, politics, ideology and so on.  On the one hand, globalization brings with its positive consequences and on the other hand also carries negative sides.  The Digital Era supports the process of Globalization to make it easier to accomplish, which makes it all easy to communicate with anyone and anytime, accessing data and information easily and quickly wherever we are especially supported by the tools of modern softwares and hardwares.  The Digital Era can also develop the capabilities of human resources must be able to adjust to use it.  For human resources who are unable to compete will be replaced with more capable ones.  However, currently Human Resources in Indonesia have not been fully encouraged to enter the Digital Era due to the constraints of several factors, such as the availability of infrastructure, the cost of digital is still inadequate when associated with the number of people with the level education and low technological understanding so they are accustomed to do jobs that do not require special skills.  Here ther role of all groups, communities and governments, to further improve the skills of human resources so as to be able to improve the economy and welfare.
Accompaniment the Successful Strategies Based on Research of Customer Loyalty
Authors: Anwar Khairil , Dewanti Retno , Chu Tjia Fie
Published: November 2021

This study aims to find out the effect of brand awareness and customer satisfaction on corporate image and its impact on customer loyalty in laurier products of PT Kao Indonesia. Customer Loyalty is one of the core goals pursued in modern marketing. By loyalty, it is expected that corporates will get long-term profitability. This study uses quantitative approach and involves 52 respondents in kelurahan Cikoko as the samples collected using probability sampling and simple random sampling techniques. Data processing employs SPSS 24 and the results of the study show that brand awareness, customer satisfaction and corporate image has significant influence on customer loyalty; therefore, the proposed program assistance is necessary to be the strategy in determining the success of customer loyalty of Laurier product.
Digitalization of Drone Monitoring Process on Indonesia Ministry of Transportation
Authors: Saputra Dany Eka
Published: November 2021

Drone has been used for various commercial activity due to its flexibility and cost efficiency. However, to ensure that each drone operation still obey safety regulation, each drone activity must be monitored and heavily regulated. The administrative process to fly a drone was cost and time consuming. All process must be conducted manually in Jakarta. This activity was conducted as part of consultancy for Directorate of Flight Navigation, Ministry of Transportation. The aim of this activity was to digitize the administrative process of drone operation. The result was a digitalization plan, which consist softwares needed for each administrative process, and implementation plan, which recommend the time and order of implementation.
The Role of Personality as A Trigger For the Satisfaction of Valuable Bag
Authors: Dewanti Retno , Nabila Siti , Simanjuntak Diana , Mohamed Zainal Siti Rohaida
Published: November 2021

Community empowerment activities through research results. This article is to investigated the influence of Hedonic Value and Utilitarian Value against Customer Satisfaction with moderating Personality has impacted to Behavioral Intentions on valuable bag. This research using Structural Equation Modeling (SEM) with Smart PLS 3.0 software. Data collected directly from respondents who meet the specified characteristics of population by distributing questionnaires. This study uses a sample of respondents who ever buy or use specific brand of bag.  The samples used in this study were 100 respondents. The research findings indicate that hedonic and utilitarian values had a direct effect on customer satisfaction and have direct effect on behavioural intentions. In addition, customer satisfaction directly influenced behavioural intentions. The role of personality as the moderate variable in this study were able to amplify between customer satisfaction and perceived value.
Karang Taruna Enterprise Development DKI Jakarta
Authors: Meiryani Meiryani , Sudrajat Jajat , Wikrama Isana
Published: November 2021

The purpose of this activity is to motivate and inspire the DKI Jakarta Youth Organization through the theme of Entrepreneurship Development for the Jakarta Youth Organization. Participants in this activity were Binus Syahdan Campus Cleaning Service officers and Anggrek representing West Jakarta Youth Organization. This activity shows the enthusiasm of the participants because of their entrepreneurial development potential, because there are already several people who already have products, but are not optimal in their packaging and marketing, currently by optimizing social media networking alone. The results of this activity have several implications, including the following; First, the implications for planning and developing the training curriculum for MSMEs, Candidates for MSMEs and Communities and teaching materials for the EN001 Entrepreneurship course, with the collaboration method of lecturers, students and MSMEs in carrying out community service activities, by optimizing the implementation of the Entrepreneurship Student Activity Program (PKM-K) through Higher Education Grants in the Indonesian Student Business Competition Program (KBMI). Second, the implications for the education and training of lecturers by using an example method of direct practical application. Third, to inspire to increase cooperation with lecturers from different study programs, so that the output can make further proposals for funding other than the Binus grant. Fourth, the implications of choosing the right training / workshop method for participants and the community as well as increasing the synergy in the implementation of the Tridharma of Higher Education.
Hydroponic Website and App to Help Communities in the Pandemic Time
Authors: Hermanus Davy Ronald , Sudrajat Jajat , Rahardjanti Titi
Published: November 2021

Hydroponic marketing app, is one of the solutions to accelerate employment problems for the community. Management of marketing information systems requires advanced technology, because information is one of the things that is very important for a company or institution time by time. Using a website media and its derivative media, namely social media app, that are well managed, delivered by thoughts and concepts of the lecturers from a university can help a community by social working. The problems of Neighbourhood Association (RT07) and Citizens Association (RW02) community members in Sarijadi Urban Village in Bandung can be overcome by increasing the interest of members of Empowerment and Family Welfare (PKK) and supported by Youth Organization (Karang Taruna) to cultivate Hydroponic plants.
Analysis of the relationship of the learning video with students 'understanding of learning materials
Authors: Arifin Yulyani , Permai Diana Syarifah , Syahchari Dicky Hida , Condrobimo Raharto
Published: November 2021

The aim of the study was to examine the relationship between the relationship between instructional videos and students' understanding of the learning material. Researchers create digital learning materials through video material (VBL), especially math in RPTRA. The researchers used correlation analysis to examine the relationship between the learning material in video form and the level of understanding of the students in the material. The method used by the researcher was to experiment with elementary-level children from various primary schools. Then, based on the experimental results, the correlation analysis test was performed to see the relationship between the student's understanding and the learning material through video. From the results of the assessment, it can be seen that the video material can help the understanding of the students and can also increase the motivation of the students in learning mathematics. Therefore, video learning can help students understand mathematics and help teachers teach mathematics in a more interesting way.
Soft Skill Development Strengthening Program Business Entrepreneurship
Authors: Setiadi Nugroho Juli , Sasongko Agung Hari , Sudrajat Jajat , Meiryani Meiryani
Published: November 2021

The program to strengthen the concept of genetic intelligence as a concept to improve student soft skills was chosen as one of the concepts and methods to be used for student entrepreneurial development using the experiential learning model. Experiential learning approach is a learning approach where knowledge is constructed through experience transformation. In the concept of genetic intelligence or familiar with the term STIFIn Concept, there are 5 parts of the brain, namely Sensing, Thinking, Intuiting, Feeling and Instinct. The brain turns out to have different parts and chemistry. The results of the STIFIn Concept analysis are knowing the dominance of a person's right or left brain, so that it can be the basis for choosing the right field of entrepreneurship, business partners and business mentors according to their genetic intelligence.
Revisitando o Uso da Transformada de Fourier no Reconhecimdnto de Voz para Robótica Móvel
Authors: Sousa Igor Rocha , Figueiredo Jefferson Calixto , Barreto Guilherme A.
Published: November 2021

Este trabalho trata do reconhecimento de comandos de voz para o acionamento de um robô móvel. Comandos básicos formados pela elocução das palavras avançar, direita, esquerda, parar e recuar são gravados por um usuário e utilizados para criação de um banco de arquivos de áudio. A partir dos áudios gravados, técnicas de extração de atributos de sinais de voz são usadas para gerar dois bancos de dados que servirão para treinamento e teste do modulo de reconhecimento de voz do software de controle do robô. Para isso, são usadas as clássicas técnicas de codificação linear preditiva (linear predictive coding, LPC) e transformada rápida de Fourier (fast Fourier transform, FFT). Em particular, a FFT e usada de um modo não usual, porém melhor adequada ao uso em sistemas embarcados. Além disso, diversas técnicas de pré-processamento são testadas sobre os atributos extraídos para avaliar possíveis impactos na acurácia dos classificadores avaliados (discriminante linear de mínimos quadrados e a rede perceptron multicamadas). A contribuição principal do estudo reside na obtenção de uma solução adequada para ser embarcada em um sistema robótico real.
Factores pronósticos que afectan la supervivencia en el paciente con mieloma múltiple
Authors: Cuervo-García Jeniffer , Jaramillo Arbelaez Patricia E , Gálvez-Cárdenas Kenny Mauricio
Published: November 2021

El mieloma múltiple es la segunda neoplasia hematológica más frecuente y se caracteriza por la expansión aberrante de las células plasmáticas monoclonales, en la mayoría de los casos con la producción de una paraproteína anormal conocida como proteína monoclonal o por evidencia de daño orgánico, manifestado por hipercalcemia, insuficiencia renal, anemia o lesiones óseas. Los factores pronósticos han evolucionado desde la caracterización de la carga tumoral utilizando el sistema de estadificación Durie y Salmon y el sistema de estadificación internacional, hasta el análisis molecular y el perfil de expresión génica, debido al reconocimiento de aberraciones cromosómicas y moleculares que desempeñan un papel en el desarrollo del mieloma múltiple y la progresión del mismo. El sistema de estadificación internacional se revisó en 2015 agregando anormalidades genéticas de alto riesgo, tales como la presencia de mutaciones t(4;14), t(14;16) y del(17p) junto con la adición de la deshidrogenasa láctica. Es así como, a lo largo del tiempo, se han identificado factores pronósticos importantes de esta neoplasia que se encuentran asociados al huésped y al microambiente tumoral, además de variables clínicas y anormalidades de las células tumorales.
Reacciones adversas asociadas a vacunas contra la COVID-19
Authors: Aguirre Morales Natalia , Gómez-Henao Catalina , Calle Ana María , Cardona-Villa Ricardo , Diez Zuluaga Libia Susana , Santamaria-Salazar Luis Carlos , Ramírez-Giraldo Ruth Helena , Chinchilla Carlos Fernando , Sánchez Jorge Mario
Published: November 2021

Con el advenimiento de la pandemia por COVID-19 se generó la necesidad de diseñar estrategias que ayudaran a mitigar la morbimortalidad causada por el virus y una de las más prometedoras es la vacunación masiva. Sin embargo, la vacunación puede asociarse a reacciones adversas, entre ellas, reacciones de hipersensibilidad a los componentes de las diferentes vacunas, por lo que es fundamental conocer dichos componentes y la población que requiere una valoración previa por Alergología. Todo paciente que lo requiera se debe remitir oportunamente con el fin de reconocer el componente implicado en la reacción por medio de pruebas adecuadas y ofrecer una conducta que permita continuar un esquema de vacunación que sea seguro. Este artículo busca recopilar los datos de reacciones adversas, con énfasis en reacciones de hipersensibilidad, que se han presentado en ensayos clínicos con la aplicación de las vacunas contra el SARS-CoV-2 para ser aplicadas en Colombia. Adicionalmente, se realiza una propuesta de abordaje de los pacientes con antecedentes de reacciones de hipersensibilidad con respecto a la conducta que se debe tomar para su vacunación.
Graphical Notation for Document Database Modeling
Authors: Smirnov M. V. , Tolmasov R. S.
Published: November 2021

Goals and objectives. Graphical models have proven to be a reliable, clear and convenient tool for creating sketch models of databases. Most of the existing notations are designed for the relational data model, the dominant data model for the last thirty years. However, the development of information technologies has led to an increase in the popularity of non-relational data models, primarily the document model. One of the problems of its application in practice is the lack of suitable tools that allow performing graphical modeling of the database, taking into account the features of the document model, at the stage of logical design. The development of appropriate tools is an important and actual task, since their application in practical research makes it possible to identify, classify and analyze typical modeling errors that allow the designer to reduce the risk of their occurrence in the future. The purpose of this article is to develop a graphical notation that, on the one hand, providing convenience for the designer, and on the other hand, taking into account the peculiarities of creating and functioning of the noSQL document storage model.Materials and methods. The materials for the study were numerous publications devoted to the development of graphical notations in problems and their application to database design for various information systems. The selected materials were analyzed and the main graphical notations used to describe the relational data model were identified. Three notations were selected from them, a set of graphic stereotypes, which were most different from each other, the analysis of which allowed us to identify the main image patterns of the components of the relational model.The resulting patterns were applied to the main elements of the document database, which were obtained by analyzing the documentation of the popular MongoDB DBMS.Results. The result of the research was the creation of a new tool for modeling document databases at the logical level, which consists of a set of graphic stereotypes and rules for their application. On the one hand, the development is well known to practitioners who have previously worked with relational data models, since its development took into account many years of experience in using graphical models in the field of relational database design, and on the other hand, it reflects the features of the structure of the document model.Conclusion. The practical application of the developed model has shown the convenience of its use both in the process of designing document databases and in the process of teaching students within this subject area. The use of graphical models constructed in the proposed graphical notation will allow researchers to create and illustrate typical patterns of document databases, which will undoubtedly have a positive impact on the dynamics of the development of promising data storage technologies.
Antioxidant activity, carbohydrates and protein in sorgum (Sorghum bicolor L. Moench) plants as a development of economic functional food materials during the COVID-19 pandemic
Authors: Antari Ni Wayan Sukma , Damayanti Ida Ayu Manik , Wulansari Nadya Treesna
Published: November 2021

This study aims to determine the content of antioxidants, carbohydrates, and protein in Sorghum (Sorghum bicolor L. Moench) as an economically functional food ingredient during the COVID-19 pandemic. The research stages include the manufacture of sorghum seed extract, Antioxidant level testing using the DPPH test, carbohydrate content testing, and protein content determination using the Kjeldahl method, the Kjeldahl method consists of 3 stages, namely: the destruction stage, the distillation stage, and the titration stage. The results showed that Sorghum had an IC50 value of 88.8970 ppm, carbohydrate content of 71.8 g, and protein content of 9.68%. so that sorghum has the potential to develop functional food during the COVID-19 pandemic.