bluuebunny/crossref_metadata_2025 huggingface dataset:
Web Series, YouTube, and Politics: Affective and Emotional Dimensions of WIGS Lauren’s User Comments
Authors: Lee Claire Shinhea
Published: January 2019

This study aims to investigate the complex relationship among entertainment contents, networked publics, and politics by offering an overview of literatures in the fields and suggests that the emotional dimensions are the key to understand the political possibilities of mediated public discussion. By analyzing the online comments of YouTube channel WIGS’s web series Lauren, this article reveals that audiences interpret and discuss this web series through mediated feelings of connectedness and thus are able to engage in public debate and political deliberation. I argue that, the connective affordances of YouTube and the emotional realism of the web-drama facilitated the web space of Lauren to function as an “emotional public sphere” where social solidarity was strengthened, political criticism was developed, and political activity could be motivated. Overall, this study reconceptualizes the place of entertainment media in democracy and everyday life and contributes to political communication and feminist media studies.
Identity Distress Throughout Adolescence and Emerging Adulthood: Age Trends and Associations With Exploration and Commitment Processes
Authors: Palmeroni Nina , Claes Laurence , Verschueren Margaux , Bogaerts Annabel , Buelens Tinne , Luyckx Koen
Published: January 2019

The process of identity formation can cause a considerable amount of distress leading to pathological forms of identity distress. The present study examined age trends in identity distress and associations with identity exploration and commitment in a sample of 2,286 Flemish adolescents and emerging adults (14–30 years, 55.7% females). Important and theoretically meaningful age trends in identity distress were uncovered. More specifically, identity distress demonstrated a curvilinear trend with the highest levels of distress occurring in emerging adulthood. Concerning the associations between identity distress and identity processes, we found differences among the age periods studied. Identity distress was especially positively related to exploration in breadth and negatively to commitment making in the late 20s, but less so in adolescence and the early 20s. In sum, these results provide important insights into identity distress throughout adolescence and emerging adulthood. Theoretical implications, limitations, and suggestions for future research are discussed.
Electronic National Agricultural Markets, Impacts, Problems and Way Forward
Authors: Reddy A. Amarender , Mehjabeen
Published: January 2019

There are about 585 Agricultural Produce Market Committee (APMC) markets which were linked to Electronic National Agricultural Market (eNAM) in 14 states in India by 2018. There was a slow but definite increase in the adoption of eNAM by the stakeholders. There has been no detailed study so far on the impact of eNAM on prices received by farmers and bottlenecks faced in introducing this e-market platform in the existing markets. This article fills this research gap. The econometric results show that there has been an increase in prices received by the farmers and more markets have linked to eNAM due to the introduction of e-auction. Other benefits of eNAM include timely online payment of sale proceeds to the farmer’s bank account and reduced chances of collusion among traders. However, on the flipside, due to lack of quick assaying facilities, participation of distant traders has not picked up, which has resulted in no significant increase in competition. There is a need for increasing the participation of the stakeholders through formation of farmers groups, private sector participation in the maintenance of eNAM, convincing the traders and commission agents to use eNAM and linking warehouses and rural periodical markets to eNAM to increase the scale, scope and efficiency of market operations.
Digital Problem-Based Learning: An Innovative and Efficient Method of Teaching Medicine
Authors: Mistry Khaylen , Chetty Natasha Casie , Gurung Puran , Levell Nick J
Published: January 2019

Background:

The breadth of knowledge assimilated by undergraduates is substantial. Time must be utilised to impart knowledge and skills to ensure optimal training. Dermatology comprises a large portion of work in primary care; yet UK undergraduate dermatology training is short. Digital problem-based learning (PBL) is an innovative teaching method incorporating clinical images into intense, interactive teaching sessions.

Aim:

To determine the efficacy of digital PBL sessions in teaching UK medical students during their dermatology module.

Methods:

In total, 59 second-year medical students at Norwich Medical School during their dermatology secondary care attachment completed two 2.5-h digital PBL sessions. One session was focused on lesions and the second on inflammatory diseases. During each session, students assessed 60 clinical cases each comprising an image with a brief history. In small groups, students discussed the cases, described the images, and agreed a diagnosis followed by a group discussion with the supervising clinician who provided feedback. Following each session, students completed a feedback questionnaire.

Results:

In total, 117 sets of feedback were received; 60% of students considered they learnt a great amount in a short time. The majority of students reported feeling more confident to make a dermatological diagnosis and more motivated in clinics as a result of the digital PBL; 64% of students found digital PBL more useful than real patient clinics. The most frequent negative comment was that 2.5 h was too long to concentrate.

Conclusions:

Digital PBL was a popular, effective, and efficient teaching method. Digital PBL sessions should be introduced alongside clinics and other teaching methods for undergraduates.
Genetics of MDS
Authors: Ogawa Seishi
Published: January 2019

Our knowledge about the genetics of myelodysplastic syndromes (MDS) and related myeloid disorders has been dramatically improved during the past decade, in which revolutionized sequencing technologies have played a major role. Through intensive efforts of sequencing of a large number of MDS genomes, a comprehensive registry of driver mutations recurrently found in a recognizable fraction of MDS patients has been revealed, and ongoing efforts are being made to clarify their impacts on clinical phenotype and prognosis, as well as their role in the pathogenesis of MDS. Among major mutational targets in MDS are the molecules involved in DNA methylations, chromatin modification, RNA splicing, transcription, signal transduction, cohesin regulation, and DNA repair. Showing substantial overlaps with driver mutations seen in acute myeloid leukemia (AML), as well as age-related clonal hematopoiesis in healthy individuals, these mutations are presumed to have a common clonal origin. Mutations are thought to be acquired and positively selected in a well-organized manner to allow for expansion of the initiating clone to compromise normal hematopoiesis, ultimately giving rise to MDS and subsequent transformation to AML in many patients. Significant correlations between mutations suggest the presence of functional interactions between mutations, which dictate disease progression. Mutations are frequently associated with specific disease phenotype, drug response, and clinical outcomes, and thus, it is essential to be familiar with MDS genetics for better management of patients. This review aims to provide a brief overview of the recent progresses in MDS genetics.
When should treatment of AL amyloidosis start at relapse? Early, to prevent organ progression
Authors: Palladini Giovanni , Merlini Giampaolo
Published: January 2019

This article has a companion Counterpoint by Sanchorawala.
Delay treatment of AL amyloidosis at relapse until symptomatic: devil is in the details
Authors: Sanchorawala Vaishali
Published: January 2019

This article has a companion Point by Palladini and Merlini.
Pore-scale fluid distributions determined by nuclear magnetic resonance spectra of partially saturated sandstones
Authors: Fang Chunhui , Pan Baozhi , Wang Yanghua , Rao Ying , Guo Yuhang , Li Jilong
Published: January 2019

The acoustic property and the P-wave velocity of partially saturated rocks depend not only on the water saturation but also on the pore-scale fluid distribution. Here, we analyzed the pore-scale fluid distribution using nuclear magnetic resonance (NMR) [Formula: see text] spectra, which present the variation of porosity components associated with NMR transverse relaxation time [Formula: see text]. Based on the [Formula: see text] spectra, we classified the pore-scale fluid distribution during water imbibition and drainage into three models: a low-saturation model, a patchy distribution model, and a uniform distribution model. We specifically assigned the low-saturation model to deal with the acoustic property of the rocks at the imbibition starting stage and the drainage final stage because cement softening has a nonnegligible effect. We studied the acoustic properties of sandstone rocks with various pore-scale fluid distributions, at the imbibition process and the drainage process. We confirmed that, once the variations in water saturation and pore-scale fluid distribution are taken into account, the P-wave velocity prediction matches well with the laboratory measurement of samples, representing nearly tight sandstone rocks that are partially saturated with distilled water.
Coherent wavefield subtraction for diffraction separation
Authors: Schwarz Benjamin
Published: January 2019

Diffractions encode subwavelength information and superior illumination but are weak in amplitude and strongly interfere with the more dominant reflected wavefield. Accordingly, the successful separation of diffractions in geophysical applications still forms a major direction of research. Confronting this challenge, an automatable and versatile framework for the separation of interfering wavefields through a sequence of coherent data summation and subtraction is proposed. In contrast to other studies using coherence measurements, the method specifically targets reflected contributions, which are normally favored in automated summation schemes, and it adaptively subtracts the resulting reflection stack from the input data. Complementing this natural selectivity of stacking, a variety of wavefront filters is presented, which can be derived from the local maximization of the semblance norm and additionally inform the subsequent separation step. Complex 2D and 3D synthetic pre- and poststack seismic examples together with a ground-penetrating radar field-data example suggest that the presented scheme can be applied to a variety of data configurations and bears the potential to uncover an extremely faint but surprisingly rich diffraction background that was previously not accessible for dedicated processing.
Duality of Purpose: Participant and Parent Understanding of the Purpose of Genomic Tumor Profiling Research Among Children and Young Adults With Solid Tumors
Authors: Marron Jonathan M. , Cronin Angel M. , DuBois Steven G. , Glade-Bender Julia , Kim AeRang , Crompton Brian D. , Meyer Stephanie C. , Janeway Katherine A. , Mack Jennifer W.
Published: January 2019

Purpose

Increasing use of genomic tumor profiling may blur the line between research and clinical care. We aimed to describe perspectives of research participants about the purpose of genomic tumor profiling research in pediatric oncology.

Methods

We surveyed 45 participants (response rate, 85%) in a pilot study of genomic profiling in pediatric solid tumors at four academic cancer centers after the return of sequencing results. We defined understanding according to a one-item (basic) definition (recognition that the primary purpose was not to improve the patient’s treatment) and a four-item (comprehensive) definition (primary purpose was not to improve patient’s treatment; primary purpose was to improve treatment of future patients; there may not be direct medical benefit; most likely result of participation was not increased likelihood of cure).

Results

Sixty-eight percent of respondents (30 of 44 respondents) demonstrated basic understanding of the study purpose; 55% (24 of 44 respondents) demonstrated comprehensive understanding. Understanding was more frequently seen in those with higher education and greater genetic knowledge according to basic (81%
v
50% [
P
= .05]; and 82%
v
46% [
P
= .03], respectively) and comprehensive (73%
v
28% [
P
= .01]; 71%
v
23% [
P
= .01]) definitions. Ninety-three percent of respondents who believed the primary purpose was to improve the patient’s care simultaneously stated that the research also aimed to benefit future patients.

Conclusion

Most participants in pediatric tumor profiling research understand that the primary goal of this research is to improve care for future patients, but many express dual goals when they participate in sequencing research. Some populations demonstrate increased rates of misunderstanding. Nuanced participant views suggest that additional work is needed to assess and improve participant understanding, particularly as tumor sequencing moves beyond research and into clinical practice.
Validation of HER2 Amplification as a Predictive Biomarker for Anti–Epidermal Growth Factor Receptor Antibody Therapy in Metastatic Colorectal Cancer
Authors: Raghav Kanwal , Loree Jonathan M. , Morris Jeffrey S. , Overman Michael J. , Yu Ruoxi , Meric-Bernstam Funda , Menter David , Korphaisarn Krittiya , Kee Brian , Muranyi Andrea , Singh Shalini , Routbort Mark , Chen Ken , Shaw Kenna R.M. , Katkhuda Riham , Shanmugam Kandavel , Maru Dipen , Fakih Marwan , Kopetz Scott
Published: January 2019

Purpose

HER2 amplification has been implicated in resistance to therapy with anti–epidermal growth factor receptor antibodies (anti-EGFRabs) in metastatic colorectal cancer (mCRC). The purpose of the study was to validate the predictive impact of HER2 amplification in mCRC.

Patients and Methods

We analyzed patients with RAS/BRAF wild-type mCRC across two distinct cohorts. In cohort 1 (n = 98), HER2 amplification was tested in tumor tissue using dual in situ hybridization ( HER2 amplification: HER2/CEP17 ratio, 2.0 or greater). Cohort 2 (n = 70) included 16 patients with HER2 amplification and 54 HER2 nonamplified controls identified by next-generation sequencing ( HER2 amplification: four or more copies) who had received prior anti-EGFRabs. The primary end point was progression-free survival (PFS) on treatment with anti-EGFRab therapy, which was estimated and compared using the Kaplan-Meier method and log-rank test.

Results

Median PFS in cohort 1 on anti-EGFRab–based therapy was significantly shorter in patients with HER2 amplification compared with HER2 nonamplified patients (2.8 v 8.1 months, respectively; hazard ratio [HR], 7.05; 95% CI, 3.4 to 14.9; P < .001). These findings were validated in cohort 2 (median PFS for HER2 amplified v nonamplified: 2.8 v 9.3 months, respectively; HR, 10.66; 95% CI, 4.5 to 25.1; P < .001). The median PFS on therapy without anti-EGFRabs was similar among HER2-amplified and nonamplified patients in both cohort 1 (9.7 v 11.1 months, respectively; HR, 1.01; 95% CI, 0.4 to 2.4; P = .97) and cohort 2 (9.6 v 11.3 months, respectively; HR, 1.21; 95% CI, 0.5 to 3.1; P = .66). In multivariable analyses, HER2 amplification emerged as a single independent predictor of poor PFS on anti-EGFRab therapy in both cohort 1 (HR, 6.48; 95% CI, 3.1 to 13.6; P < .001) and cohort 2 (HR, 10.1; 95% CI, 4.3 to 23.9; P < .001).

Conclusion

HER2 amplification in RAS/RAF wild-type mCRC seems to be a predictive biomarker for lack of efficacy of anti-EGFRab therapy. Screening patients with RAS/BRAF wild-type mCRC for HER2 amplification should be considered before anti-EGFRab treatment to guide therapy and to identify patients for early referral to clinical trials.
Reconstituting the reticular ER network – mechanistic implications and open questions
Authors: Wang Ning , Rapoport Tom A.
Published: January 2019

The endoplasmic reticulum (ER) is a major membrane-bound organelle in all eukaryotic cells. This organelle comprises morphologically distinct domains, including the nuclear envelope and peripheral sheets and tubules. The tubules are connected by three-way junctions into a network. Several membrane proteins have been implicated in network formation; curvature-stabilizing proteins generate the tubules themselves, and membrane-anchored GTPases fuse tubules into a network. Recent experiments have shown that a tubular network can be formed with reconstituted proteoliposomes containing the yeast membrane-fusing GTPase Sey1 and a curvature-stabilizing protein of either the reticulon or REEP protein families. The network forms in the presence of GTP and is rapidly disassembled when GTP hydrolysis of Sey1 is inhibited, indicating that continuous membrane fusion is required for its maintenance. Atlastin, the ortholog of Sey1 in metazoans, forms a network on its own, serving both as a fusion and curvature-stabilizing protein. These results show that the reticular ER can be generated by a surprisingly small set of proteins, and represents an energy-dependent steady state between formation and disassembly. Models for the molecular mechanism by which curvature-stabilizing proteins cooperate with fusion GTPases to form a reticular network have been proposed, but many aspects remain speculative, including the function of additional proteins, such as the lunapark protein, and the mechanism by which the ER interacts with the cytoskeleton. How the nuclear envelope and peripheral ER sheets are formed remain major unresolved questions in the field. Here, we review reconstitution experiments with purified curvature-stabilizing proteins and fusion GTPases, discuss mechanistic implications and point out open questions.
Sizing it all up
Authors: White Hilary
Published: January 2019

In this second of a series on ‘maths talk’ we look at how practitioners can introduce size terminology to children's play. Through free exploration they will discover how size and length affect outcomes.
Listen to this
Authors: Hart Karen
Published: January 2019

Playing outdoors with friends is a perfect way to boost communication skills and these simple games are easy to set up. Children will enjoy sharing and talking about their tactile, sensory experiences.
Letters home
Authors: Harries Judith
Published: January 2019

Have fun reading all the letters in The Jolly Postman and encourage children to compose their own letters, supporting them to create simple sentences and even a Valentine's Day message.
Revisiting the “An Improved Remote user Authentication Scheme with Key Agreement”
Authors: CHEN YALIN , CHOU JUE-SAM , LIAO I - CHIUNG
Published: January 2019

Recently, Kumari et al., pointed out that Chang et al.’s scheme “Untraceable dynamic-identity-based remote user authentication scheme with veriﬁable password update” has several drawbacks and does not provide any session key agreement. Hence, they proposed an improved remote user authentication scheme with key agreement based on Chang et al.’s protocol. They claimed that the improved method is secure. However, we found that their improvement still has both anonymity breach and smart card loss password guessing attack which cannot be violated in the ten basic requirements advocated for a secure identity authentication using smart card by Liao et al. Thus, we modify their protocol to encompass these security functionalities which are needed in a user authentication system using smart card.
Use of Mathematical Morphology in Vehicle Plate Detection
Authors: MOHANAN NEERAJA , AHMAD AFAQ , AL-BUSAIDI SAYYID SAMIR , KHIRIJI LAZHAR , ABDULGHANI AMIR , AL NADABI MUHAMMAD
Published: January 2019

In the past couple of decades, the number of vehicles has increased radically. A statistic which presents the number of cars sold worldwide from 1990 through 2017, forecasts for 2018, some 81.6 million automobiles are expected to be sold by the end 2018. With this continuous increase, it is becoming very tedious to keep track of each vehicle for the purpose of security, law enforcement and traffic management. This phenomenon of rapidly increasing vehicles on the road highlights the importance for a vehicle number plate recognition system. By recognizing the car plates, the drivers of the vehicle can be identified from the database. Number plate detection system are used in various applications like traffic law maintenance, traffic control, automatic toll collection, parking systems, automatic gate openers. This paper presents a unique algorithmic procedure for detecting vehicle plate number which is based on the concept of mathematical morphology. The developed algorithm is simple, efficient and flexible. The algorithm is capable of working satisfactorily even in different constraints such as like rain, smoke and shadow. This user-friendly software tool is developed on MATLAB platform which is one of the common and efficient image processing analysis tools.
Simulation Approach for Logistical Planning in a Warehouse: A Review
Authors: FAUADI M.H.F. MD. , AZIMI N.Z. , ANUAR N.I. , ALI M.M. , SUED M.K. , RAMLAN S.
Published: January 2019

Simulation approach has been widely utilized for design and planning of a warehouse logistic system. As technology advances, better simulation tools have been developed. This enables decision makers to create more realistic models to represent the actual scenario. As a result, better evaluation could be made especially regarding dynamic factors within system. Thus, complex logistic problems could be solved. This paper reviews the fundamentals of warehouse logistic and the simulation tools available to analyze logistic problems.
Hostel Management System Based on Finger Print Authentication
Authors: RAJKUMAR G. , SUNDARI T. SIVAGAMA
Published: January 2019

The biometric system plays the most important role in this current century. Finger print identification is one among the foremost distinguished and familiar identity verification system due to its individuality. Security within the hostel is one of the foremost repetitive issues. To keep up day by day attendance verification is sophisticated and time consuming system for the hostel management. There are number of existing attending systems are available for college students, for hostel students it must improve. Within the existing system wardens are manually maintain the attendance for hostel students. This paper deals with, avoid of an entire problem in hostel management system together with this monitoring system also proposed. The administrator of this system was college principal or warden. Biometric system is used to accommodate a large number of students within the hostel. This system makes automatically to monitor the entry and exit of students from hostel and offers alert SMS to parents for their safety.
Reproducibility and Variability of Protein Analytes Measured Using a Multiplexed Modified Aptamer Assay
Authors: Tin Adrienne , Yu Bing , Ma Jianzhong , Masushita Kunihiro , Daya Natalie , Hoogeveen Ron C , Ballantyne Christie M , Couper David , Rebholz Casey M , Grams Morgan E , Alonso Alvaro , Mosley Thomas , Heiss Gerardo , Ganz Peter , Selvin Elizabeth , Boerwinkle Eric , Coresh Josef
Published: January 2019

Background

There is growing interest in the use of multiplexed aptamer-based assays for large-scale proteomic studies. However, the analytic, short- and long-term variation of the measured proteins is largely uncharacterized.

Methods

We quantified 4001 plasma protein analytes from 42 participants in the Atherosclerosis Risk in Communities (ARIC) Study in split samples and at multiple visits using a multiplexed modified aptamer assay. We calculated the CV, Spearman correlation, and intraclass correlation (ICC) between split samples and evaluated the short-term (4–9 weeks) and long-term (approximately 20 years) variability using paired t-tests with log-transformed protein concentrations and Bonferroni-corrected significance thresholds. We performed principal component (PC) analysis of protein analyte concentrations and evaluated their associations with age, sex, race, and estimated glomerular filtration rate (eGFR).

Results

The mean baseline age was 57 years at the first visit, 43% of participants were male and 57% were white. Among 3693 protein analytes that passed quality control, half (n = 1846) had CVs < 5.0%, Spearman correlations > 0.89, and ICCs > 0.96 among the split samples. Over the short term, only 1 analyte had a statistically significant difference between the 2 time points, whereas, over approximately 20 years, 866 analytes (23.4%) had statistically significant differences (P < 1.4 × 10−5, 681 increased, 185 decreased). PC1 had high correlations with age (−0.73) and eGFR (0.60). PC2 had moderate correlation with male sex (0.18) and white race (0.31).

Conclusions

Multiplexed modified aptamer technology can assay thousands of proteins with excellent precision. Our results support the potential for large-scale studies of the plasma proteome over the lifespan.
A Rapid Dilute-and-Shoot UPLC-MS/MS Assay to Simultaneously Measure 37 Drugs and Related Metabolites in Human Urine for Use in Clinical Pain Management
Authors: Dahlin Jayme L , Palte Michael J , LaMacchia John , Petrides Athena K
Published: January 2019

Background

Monitoring of medication compliance and drug abuse is used by clinicians to increase patient prescription drug compliance and reduce illicit drug abuse and diversion. Despite available immunoassays, chromatography-mass spectrometry–based methods are considered the gold standard for urine drug monitoring owing to higher sensitivities and specificities. Herein, we report a fast, convenient ultraperformance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) assay to detect or quantify 37 clinically relevant prescription drugs, drugs of abuse, and related glucuronides and other metabolites in human urine by single diluted sample injection.

Methods

Analytes consisted of prescription and illicit opioids, benzodiazepines, and drugs of abuse, including parent compounds and glucuronidated and nonglucuronidated metabolites. Urine samples were diluted with water and supplemented with deuterated internal standards without enzymatic hydrolysis, analyte extraction, or sample purification. Analytes were separated by reversed-phase UPLC and quantified by positive-mode electrospray ionization and collision-induced dissociation MS. Assay validation followed Food and Drug Administration bioanalytical guidelines.

Results

Total analytical run time was 5.5 min. All analytes demonstrated acceptable inter- and intraassay accuracy, imprecision, and linearity throughout clinically relevant analytical ranges (1–2000 ng/mL, depending on analyte). All analytes demonstrated acceptable selectivity, stability, matrix effects, carryover, and performance compared to national reference laboratory or previously validated in-house methods. A total of 23 and 14 analytes were validated for quantitative and qualitative testing, respectively.

Conclusions

A convenient UPLC-MS/MS assay for simultaneously monitoring 37 analytes in human urine was validated for use in pain management testing. Advantages of this multiplex assay include facile sample preparation and higher-throughput definitive detection including glucuronide metabolite quantification.
Reapproaching Old Buildings within the City
Authors: Fortuna Carlos
Published: January 2019

Suddenly for some reason I thought of Brasilia. The city of Brasilia was inaugurated in 1960. It was a perfect multidisciplinary exercise of harmonization between the urban planner (Lúcio Costa), the architect Óscar Niemeyer), and the landscape artist-architect (Roberto Burle Marx). Moreover, Brasilia was a typical construction of a city by the conquest of the open space made of sheer optimism, the triumph of talent over doubt and of the audacity over pessimism (Gorelik, 2005).

This reference to Brasilia serves as a sort of epigraph with which I will unravel some of my loose topics about the role of old buildings in reapproaching the contemporary city. I have never addressed specifically a journal for architects, city planners, or urban designers. On the contrary, I am far more used to deal with urban issues for groups of social scientists, sociologists, like myself, historians, anthropologists, geographers, and so forth. Here I am anyway, trying to address the issue of buildings and their possible reuses upon an interdisciplinary view, counting on your benevolence.
Drawing is Not Enough. Design Tools for the Reuse of Modernist Buildings
Authors: Gaenshirt Christian
Published: January 2019

This paper[i] re-discusses the question of design tools, a metaphor that lately has been used for different things such as simple objects, media, cultural techniques, computer programs, formal principles or thinking strategies. After reviewing recent research on design tools, a taxonomy will be proposed. The key tool for the reuse of modernist buildings though remains the building itself, and its related narratives.

 

[i] The author would like to thank Xi'an Jiaotong-Liverpool University, in Suzhou, China, for generously founding his work on this research, as well as his travel to participate in the RMB conference in April 2018 at the University of Coimbra, Portugal. He also would like to thank Shayne Jones for disucssing and revising earlier versions of this text.
Meanwhile Use as an Act of Resistance
Authors: Leyssen Dieter
Published: January 2019

In this paper, the role of meanwhile use as an act of resistance is examined. Can temporal reuse of buildings awaiting redevelopment affect the decisions of architects, policymakers and developers over plans for adaptation or demolition? In recent years, we have seen an increase in practices of meanwhile use in this context. Examples can be found in many European and American cities: relict spaces temporarily turned into bars or co-working environments, vacant offices into galleries, wastelands into vegetable gardens, etc. Important differences surface in terms of process, ideology, politics of space, activism and power relations. The ultimate beneficiary of meanwhile use is often unclear and diverse over cases. Different authors highlighted its catalyst role in processes of gentrification and displacement and identified it as placemaking tool for developers or public authorities. Others thought it a useful method in the adaptive re-use of buildings, learning from every-day uses when imagining future adaptations. This paper scrutinises the role of meanwhile use, operating critically from within redevelopment projects. The analysis draws on practical experiences in a project of meanwhile use in the CIAM-inspired Brussels North District. Alongside interviews with diverse agents, some of the tactical and inter-personal dimensions are being revealed. Using literature from critical urbanism, post-colonial theory, and actor-network theory and findings from the paper's case study, five conditions are crystallised for meanwhile use to be an act of resistance, affecting the outcome of redevelopment projects.
Evolution of bioacoustic correlometers: from setups for analysis of probability density function (PDF), cumulative distribution function (CDF), [spectral] entropy of signal (SE) & quality of masking noise (QMN) to palmtop-like pocket devices
Authors: Gradov Oleg , Adamovich Eugene , Pankratov Serge
Published: January 2019

Evolution of bioacoustic correlometers: from setups for analysis of probability density function (PDF), cumulative distribution function (CDF), [spectral] entropy of signal (SE) & quality of masking noise (QMN) to palmtop-like pocket devices

Novel references:
Angiotensins and rheumatoid arthritis
Authors: Savushkina N. M. , Galushko E. A. , Demidova N. V. , Gordeev A. V.
Published: January 2019

At present, the role of the renin-angiotensin system (RAS) in regulating the cardiovascular system and maintaining water and electrolyte homeostasis has been well studied. However, over the past decades, new components of the RAS have been identified, suggesting a wider range of its potential effects on the body. It is of fundamentally importance for rheumatologists to affect inflammation, including rheumatoid inflammation, through blockade of angiotensin (AT) II formation via the effects of AT 1–7 and angiotensin-converting enzyme inhibitors, as well as through suppression of angiogenesis, primarily by reducing the production of endothelial growth factor. The organ-protective and antiinflammatory potential of drugs that reduce the production of AT, which has been proven in in vitro and in vivo experiments, allows us to consider them as first-line angiotropic agents in patients with rheumatoid arthritis, especially in the presence of concomitant hypertension and/or nephropathy.
Therapy for digital ulcers in patients with systemic scleroderma
Authors: Starovoitova M. N. , Desinova O. V.
Published: January 2019

As of now, there are several pharmacological directions in the treatment and prevention of Raynaud’s syndrome and digital ulcers, including various vasoactive drugs (calcium channel blockers, intravenous prostanoids, endothelin receptor antagonists, phosphodiesterase 5 inhibitors, antiplatelets, and statins). The approach to treating systemic sclerosis-related digital ulcers is multifactorial: prevention of risk factors, local and systemic drug treatment, and surgical treatment if necessary.
A clinical case of early successful diagnosis and treatment of relapsing polychondritis
Authors: Sukhikh E. N. , Simonova O. V.
Published: January 2019

Relapsing polychondritis (RP) is a generalized progressive autoimmune inflammatory disease of the cartilaginous tissue, which leads to structural changes in the cartilage until its complete disappearance. To date, about 800 RP cases have been described in the world. The clinical manifestations of RP are diverse, which often complicates the early diagnosis of the disease. The most commonly used drugs to stop RP activity are glucocorticoids, the dose of which depends on the severity of its clinical manifestations, but there is no evidence for their effect on the progression of the process and the risk of relapse. The paper describes a clinical case of early diagnosis and successful treatment of the disease, which could prevent possible complications and disability in the patient.
Rheumatoid arthritis classification criteria: debatable problems
Authors: Muravyev Yu. V. , Misiyuk A. S.
Published: January 2019

The paper discusses the issues of imperfect 1987 American College of Rheumatology (ACR) and the 2010 ACR/European League Against Rheumatology (EULAR) rheumatoid arthritis classification criteria and justifies the need for their correction.
Vernakularisasi dalam Tafsir Nusantara: Kajian atas Tafsir Faid al-Rahman karya KH. Sholeh Darat al-Samarani
Authors: Faiqoh Lilik
Published: January 2019

This research discusses about vernacularization in Tafsir Nusantara: The Study of Tafsīr Faiḍ al-Raḥmān by KH. Sholeh Darat al-Samarani. There is a Tafsir Nusan- tara which  appears with title of the book is Tafsīr Faiḍ al-Raḥmān fī Tarjamāh Tafsīr Kalām Malik ad-Dayyān by KH. Sholeh Darat al-Samarani who lives in the last of 19th century and in the beginning of 20th  century, as well the first mufassir who writes tafsir that use Javanese language with the alphabet letter of Arabic, the authors are interested to discuss Tafsīr Faiḍ al-Raḥmān. This research raises two form of problems about How vernacularization in Tafsīr Faiḍ al-Raḥmān in terms of language and how vernacularization in Tafsīr Faiḍ al-Raḥmān in terms of interpretation. By using vernacularization theory will be explained that to apply in Tafsīr Faiḍ al-Raḥmān appropriate with vernacularization process in the phenomena of the text which has developed in Tafsīr Faiḍ al-Raḥmān. So, this research can be concluded, first vernacularization in terms of lan- guage include word pengupo jiwo, nyumet damar, and saklas. Vernacularization in terms of language Tafsīr Faiḍ al-Raḥmān more describes about distinctive language of locality that is commonly used by local society. The second, vernacularization in terms of interpretation include Q.S. al-Fātiḥah ([1]: 2), and Q.S. al-Baqarah ([2]: 17), Q.S. al-Baqarah ([2]: 219). Vernacularisation of interpretation in Tafsīr Faiḍ al-Raḥmān more describes about localities’ expression, behaviors and attitudes of Javanese people, the nature of plants in Java and the realms of life in Java.
Epistemologi Hermeneutika Hassan Hanafi
Authors: Solahuddin Ahmad
Published: January 2019

In previous research, many scholars concern to study a Hassan Hanafi's Hermeneutic in Qur'an, although Hanafi did not write anything about Hermeneutic or Qur'anic Sciences (Ulum al-Qur'ān). These researchers aware that their research was weak and needed further research. Therefore, this research sought to continue these researches in order to welcome a new book entitled 'Science of the Qur'an' (ulum al-Qur'ān) written and published by Hassan Hanafi recently. The researcher will discover Hanafi's Hermeneutic from the epistemologicly perspective. From this research, we can conclude that the basic assumptions of the Hermeneutics of Hasan Hanafi: that a Muslim should shift their view from the al-Ḥawāmil al-Qur'āniah to the Qur'ānic spirit. Al-Ḥawāmil al-Qur'ānia are the language, the social environment, the geographic places and the historical times of the Qur'an. The Qur'ānic spirit is God's science carried by the Qur'an. The types of approaches that were in the Hassan Hanafi approach to Hermeneutic are: the objective approach or the historical approach, the subjective objectivity approach, and linguistic approach. The source of the Hermeneutics approach at Hassan Hanafi is oral narratives and codified texts.
IDEOLOGI TAKFIRI MUHAMMAD AL-MAQDISI: Memahami Hubungan Beragama dan Bernegara Perspektif Maqāshid asy-Syarī‘ah
Authors: Widodo M. Hafidh
Published: January 2019

The term "kaafir" (infidel) has existed since the time of the Prophet Muhammad.  In the Koran, it is stated that kaafir is a person who does not believe that Allah Swt. as God Almighty, people who worship idols, and Ahl Kitab (Jewish and Christian). The meaning of this term then changed, not only aimed at non-Muslims but also addressed to Muslims themselves. Muhammad  al- Maqdisi accused kaafir of those who did bid'ah, for those who made laws and those who followed laws other than the laws of the Koran and al-Hadith—then the Law, the 1945 Constitution, and Pancasila included kaafir products. As a consequence, they have been considered apostates and truly have become non-Muslims, and their blood is halal to be killed. The question is "how did the takfiri ideological concept according to Muhammad al-Maqdisi relate to religion and state".
Pergeseran Makna dan Tujuan Pembacaan Burdah di Desa Jaddung, Pragaan, Sumenep
Authors: Ramin Maghfur M
Published: January 2019

The narration of Burdah reading became a feature of understanding in the religious life of the Jaddung community, Pragaan, Sumenep, Madura, East Java. In the Burdah reading has been a displacement meaning, from praise and expressions of love to the Prophet to the treatment of people who feel pain. Religious rituals and their behavior indicate a deviation in their religious understanding. This has even led to the sacredness of hope for life or death. The anxiety shows the process of changing or shifting the meaning of the Burdah tradition from praise to treatment. This happened because of the construction of people's knowledge to respond to the out- break of Ta'on disease in the 1960s, sick without cause in the 1970s, and people who had long been seriously ill in the 1980s. When awareness of health and knowledge develops as it is today, the tradition of Burdah reading continues to be a theological conviction to understand about life's hopes or hopes about reality regarding death. This reality encourages the writer to examine it more seriously with Gadamer's Hermeneutic analysis. The focus of this study leads to the existence of the Burdah tradition, understanding narration, and the theology of community expectations of Jaddung, Pragaan, Sumenep, East Java.
Reverse Stein–Weiss Inequalities on the Upper Half Space and the Existence of Their Extremals
Authors: Chen Lu , Lu Guozhen , Tao Chunxia
Published: January 2019

The purpose of this paper is four-fold. First, we employ the reverse weighted Hardy inequality in the form of high dimensions to establish the following reverse Stein–Weiss inequality on the upper half space:

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\int_{\mathbb{R}^{n}_{+}}\int_{\partial\mathbb{R}^{n}_{+}}\lvert x|^{\alpha}|x% -y|^{\lambda}f(x)g(y)|y|^{\beta}\,dy\,dx\geq C_{n,\alpha,\beta,p,q^{\prime}}\|% f\/\|_{L^{q^{\prime}}(\mathbb{R}^{n}_{+})}\|g\|_{L^{p}(\partial\mathbb{R}^{n}_% {+})}

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Second, we show that the best constant of the above inequality can be attained. Third, for a weighted system analogous to the Euler–Lagrange equations of the reverse Stein–Weiss inequality, we obtain the necessary conditions of existence for any positive solutions using the Pohozaev identity. Finally, in view of the stereographic projection, we give a spherical form of the Stein–Weiss inequality and reverse Stein–Weiss inequality on the upper half space

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On p-Robust Saturation on Quadrangulations
Authors: Westerdiep Jan
Published: January 2019

For the Poisson problem in two dimensions, posed on a domain partitioned into
axis-aligned rectangles with up to one hanging node per edge, we envision an
efficient error reduction step in an instance-optimal hp-adaptive finite
element method. Central to this is the problem: Which increase in local polynomial degree
ensures p-robust contraction of the error in energy norm? We reduce this problem to a small
number of saturation problems on the reference square, and provide strong numerical
evidence for their solution.
Sample size calculations for the differential expression analysis of RNA-seq data using a negative binomial regression model
Authors: Li Xiaohong , Wu Dongfeng , Cooper Nigel G.F. , Rai Shesh N.
Published: January 2019

High throughput RNA sequencing (RNA-seq) technology is increasingly used in disease-related biomarker studies. A negative binomial distribution has become the popular choice for modeling read counts of genes in RNA-seq data due to over-dispersed read counts. In this study, we propose two explicit sample size calculation methods for RNA-seq data using a negative binomial regression model. To derive these new sample size formulas, the common dispersion parameter and the size factor as an offset via a natural logarithm link function are incorporated. A two-sided Wald test statistic derived from the coefficient parameter is used for testing a single gene at a nominal significance level 0.05 and multiple genes at a false discovery rate 0.05. The variance for the Wald test is computed from the variance-covariance matrix with the parameters estimated from the maximum likelihood estimates under the unrestricted and constrained scenarios. The performance and a side-by-side comparison of our new formulas with three existing methods with a Wald test, a likelihood ratio test or an exact test are evaluated via simulation studies. Since other methods are much computationally extensive, we recommend our M1 method for quick and direct estimation of sample sizes in an experimental design. Finally, we illustrate sample sizes estimation using an existing breast cancer RNA-seq data.
Mulheres líderes em Educação. Da Baixada Fluminense para o mundo.
Authors: Malachias Rosangela
Published: January 2019

O artigo descreve reflexivamente as etapas concluídas e bem sucedidas do Projeto de Pesquisa e Extensão iniciado em 2015 na Universidade do Estado do Rio de Janeiro, campus FEBF – Faculdade de Educação da Baixada Fluminense em Duque de Caxias, RJ, Brasil. A narrativa transita entre pessoalidade e impessoalidade compatíveis ao deslocamento identitário (HALL) da autora, que também é uma mulher negra, docente em uma universidade pública brasileira, protagonista e mediadora das ações construídas coletivamente com estudantes. A autodefinição e a autoavaliação (COLLINS) tem sido uma característica de pesquisas produzidas por e sobre mulheres negras.Palavras chave: Mulheres Negras – Líderes – Educação – Educomunicação - Diálogos.  ABSTRACT The article describes the successful stages of the Research and Extension Project begun in 2015 at the Rio de Janeiro State University (UERJ),  School of Education from Baixada Fluminense (FEBF) in Duque de Caxias, RJ, Brazil. The narrative transits between personal and not personal style that is compatible with the author's displacement (HALL), as a black woman, a teacher at a Brazilian public university, and a protagonist and mediator of the actions constructed collectively with students. Self-definition and self-evaluation (COLLINS) has been a feature of research produced by and about black women. Keywords: Black Women - Leaders - Education - Educommunication - Dialogues.
Estratégias de saúde realizadas por/para mulheres negras nas Américas: revisão de escopo
Authors: Prestes Clélia R. S. , L. Fachim Felipe , S. F. Paiva Vera
Published: January 2019

Este artigo apresenta um panorama de estratégias de promoção da saúde de mulheres negras, voltadas à potencialização de resiliência, agência, emancipação, autonomia ou empoderamento. Os dados apresentados neste artigo correspondem a parte dos resultados coletados por uma revisão sistemática de escopo, que integrou a pesquisa “Estratégias de promoção da saúde de mulheres negras: interseccionalidade e bem viver”, com descrição de experiências reconhecidas no campo científico.  Discutimos 11 estratégias estadunidenses e 1 brasileira, apresentando seus objetivos, perspectivas teóricas, descrições, quem as realizou, perfil de participantes, método, técnicas e instrumentos, além de discutir alguns resultados e o panorama geral, em diálogo com as perspectivas teóricas da abordagem multicultural dos direitos humanos na saúde e do feminismo negro. Ao final, apontamos recomendações para agendas futuras, no sentido da atenção à interseccionalidade como método de análise e de ação, produções teóricas de diversas regiões, epistemologias e cosmovisões, consideração das demandas específicas, responsabilidade ampla pela saúde das mulheres negras, valorização das experiências das mesmas, incluindo as não-acadêmicas, o feminismo negro como estratégia de enfrentamento das colonialidades de poder, diversidade na formação de equipes e fontes teóricas, ampliação das publicações de pesquisadoras(es) negras(os) e do movimento social negro e de mulheres negras, e ampliação das vozes de autoras(es) amefricanas(os).
Mostra Tela Indígena – 13 a 18 de setembro de 2018, Cine Capitólio, Porto Alegre, RS, Brasil. E outros comentários sobre filmes indígenas contemporâneos no Brasil.
Authors: Dos Santos Eloína Prati
Published: January 2019

O texto se propoe a resenhar a mostra cinematográfica intitulada Tela Indígena, que aconteceu entre 13 e 18 de setembro de 2018, no Cine Capitólio, em Porto Alegre, RS, Brasil. Além disso, tece outros comentários sobre filmes indígenas contemporâneos no Brasil.
BOUVET, Rachel; OLIVIERI-GODET, Rita, org. Geópoétique des confins. Rennes : Presses Universitaires de Rennes, 2018. 216p
Authors: Bernd Zilá
Published: January 2019

Resenha do livro BOUVET, Rachel; OLIVIERI-GODET, Rita, org. Geópoétique des confins. Rennes : Presses Universitaires de Rennes, 2018. 216p