bluuebunny/crossref_metadata_2025 huggingface dataset:
The relation between interleukin-6 and interleukin-8 serum levels and the severity of acquired aplastic anemia in adult patients: A single center study
Authors: Abdelfatah Rana ,   Department of Internal Medicine and Hematology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Egypt.
Published: July 2024

Aplastic anemia is a lethal bone marrow disease with a heterogeneous etiological background. Interleukin-6 (IL-6) and IL-8 were shown to affect the proliferation and differentiation of primitive hematopoietic cells. They may serve as potential markers for the assessment of severity/prognosis of aplastic anemia. The study aimed to evaluate the levels of IL-6 and IL-8-in patients with aplastic anemia and their relation to disease severity. This study included a total of 35 cases of aplastic anemia, and 27 normal subjects as controls. Levels of IL-6 and IL-8 were quantitatively measured by ELISA. The median serum IL-6 and IL-8 levels in aplastic anemia cases were 125.2 ng/l and 320 ng/l, respectively. These levels were significantly increased in the aplastic anemia patients than in the controls, as the median serum IL-6 was 29.7 ng/l and the median serum IL-8 97ng/l in the controls (p< 0.001). A significant correlation was observed between levels of both IL-6 and IL-8 and the severity of the disease (p<0.001). In conclusion, IL-6 and IL-8 serum levels are higher in patients with aplastic anemia and have a correlation to the severity of the disease.
Serum calgranulin C as a non-invasive predictor of activity among inflammatory bowel disease
Authors: Rasmy Hany ,   Department of Internal Medicine, Hepatology & Gastroenterology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Published: July 2024

Inflammatory bowel disease is a chronic immune-mediated disorder with a relapsing and remitting course. It leads to disabling gastrointestinal symptoms, low quality of life, and a significant burden for healthcare utilization and associated costs. Therefore, non-invasive biomarkers are needed for early diagnosis and follow up to avoid the complications of invasive diagnostic procedures. Calgranulin C is a calcium binding protein with proinflammatory properties. The aim of this study was to evaluate the role of serum calgranulin C as a non-invasive biomarker for diagnosis and prediction of activity in comparison to different biomarkers and endoscopic activity scores in inflammatory bowel disease. The study included 80 inflammatory bowel disease patients (50 Ulcerative colitis and 30 Chron’s patients) and 20 normal controls. Complete blood picture, C-reactive protein, erythrocyte sedimentation rate, fecal calprotectin and serum calgranulin C were measured. Colonoscopies with histopathological examination were done and different activity scoring systems assessed. Among ulcerative colitis group, serum calgranulin C was statistically significantly higher in comparison to control group [723.640±529.055 ng/ml versus 80.850±24.416 ng/ml]. Depending on the American college of gastroenterology ulcerative colitis activity index, fecal calprotectin and serum calgranulin C were statistically significantly higher among moderate to severe ulcerative colitis than those with mild activity and those in remission (p <0.001, for both). Regarding Crohn’s disease group, serum calgranulin C was statistically significantly higher in comparison to control group [759.233±797.963 ng/ml versus 80.850±24.416 ng/mL]. Depending on Crohn’s disease activity index, both serum calgranulin C and fecal calprotectin were statistically significantly higher among active disease than those in remission (p <0.001, for both). In conclusion, serum calgranulin C could be used as a non-invasive marker to predict activity and severity and to ensure remission among inflammatory bowel disease patients.
Interleukin-10 as a marker for response to dendritic cells-dribbles immunotherapy in hepatocellular carcinoma, a mice model
Authors: Abdelhadi Amina ,   Department of Medical Microbiology & Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Published: July 2024

Cancer immunotherapy is a promising strategy in cancer management, including hepatocellular carcinoma (HCC). This experimental study aimed to evaluate interleukin-10 (IL-10) as a biomarker for monitoring the response of tumor-derived autophagosomes vaccine in inducing antitumor immunity in HCC induced mice. It was conducted on 56 BALB/c mice; divided into 20 normal and 36, cancer induced with human liver cancer cell line (HepG2) cells. The latter group was subdivided into a positive control group (n=6) and a treated group (n=30), that was subdivided into 3 subgroups: (A) treated with dendritic cells (DC) vaccine only, (B) treated with vaccine named Dribbles only, and (C) treated with DC plus Dribbles. Serum IL-10 was assessed after immunotherapy. The mean percentage of tumor volume reduction in mice vaccinated by DC plus Dribbles was significantly superior to DC and Dribbles groups (p= 0.013, and p= 0.043, respectively). There was a statistically significant difference in IL-10 levels between different immunotherapy groups (p= 0.0003). As the mean IL-10 level was 19.50 pg/ml for the positive control group, 13 pg/ml for Dribbles group, 10 pg/ml for DCs group and 3.50 pg/ml for DCs plus Dribbles group. We conclude that DC-Dribbles vaccine has a remarkable efficacy superior to either Dribbles alone or DC alone in the decline of HCC development and survival improvement. IL-10 is a predictive biomarker for response after immunotherapy.
Serum calprotectin as an inflammatory marker in psoriatic arthritis patients: Relation to disease activity and musculoskeletal ultrasound findings
Authors: Hamada Magdeldin ,   Department of Internal Medicine, Rheumatology & Clinical Immunology Unit, Faculty of Medicine, Ain Shams University, Cairo,, Egypt.
Published: July 2024

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis. The use of inflammatory markers can be disappointing in PsA since they are elevated in only about half of the patients. This study aimed to measure serum calprotectin level in PsA patients and to assess its association with disease activity in PsA (DAPSA) and musculoskeletal ultrasound findings. The study included 50 PsA patients and 30 controls. All subjects underwent medical history, musculoskeletal examination, hand and wrist joints ultrasound, and laboratory assessment. The mean age of patients was 41.04±11.8 years with female: male ratio of 3:2, and the median duration of arthritis 2 years (1-4 years) and DAPSA 25 years (3-84 years). The most common finding in patients by ultrasound was synovial hypertrophy in wrist joint (32%) followed by hand joints (28%). Patients' serum calprotectin level was significantly higher (174.2 ng/ml; ranged 127.5-282.6 ng/ml) than controls 41.4 ng/ml; ranged 19.9-59.8 ng/ml) (p<0.001). Serum calprotectin predicted the occurrence of PsA at cutoff >106.4 ng/ml (with sensitivity 98%, and specificity 86.6%; p=0.001) and predicted synovial hypertrophy in hand joints at cutoff >258.9 ng/ml (with sensitivity 71%, and specificity 83%). There was a significant relation between serum calprotectin with synovial hypertrophy (p=0.004), osteophytes (p<0.0001), nail affection (p=0.03) and erosions (p=0.01). Serum calprotectin is a more potential predictor for PsA (p<0.0001) compared to erythrocyte sedimentation rate (p=0.005) and C-reactive protein (p=0.001). In conclusion, serum calprotectin level is significantly high in PsA patients. It is associated with small hand joints synovitis and nail changes. This makes it a promising biomarker for defining patients with suspected PsA who do not meet specific disease criteria.
Neutrophils and monocyte toll like receptors 2 and 4 expression in preterm versus term delivery
Authors: Badawy Eman ,   Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Published: July 2024

Pregnancy results in an increase in immune cells, especially monocytes, which enhances the innate immune system. The increase of inflammatory cytokines in pregnant women's amniotic fluid, can cause uterine contraction, is linked to preterm labor. These inflammatory responses are controlled by Toll-like receptors (TLRs), which are largely expressed on neutrophils and monocytes. This study aimed to determine the role of neutrophils and monocyte subsets, as well as their expression of TLR-2 and TLR-4 in women with preterm and full-term delivery. The study involved a total of 74 women, comprising of 29 preterm labor, 25 full-term labor, and 20 non-pregnant women. The distribution of three monocyte subsets, namely (CD14++CD16-), (CD14+CD16+), and (CD14-/dim CD16++) was measured. Also, the expression of TLR2 and TLR4 in monocytes and neutrophils was analyzed using flow cytometry. Non-classical monocytes and intermediate monocytes were significantly higher in the preterm group than the control and full-term groups (p=0.041, p=0.043, and p=0.004, p= 0.049, respectively). Women in the preterm group showed significantly TLR2 expression on nonclassical monocytes compared to the control and full-term groups (p=0.002, and p=0.010, respectively). Also, preterm group expression of TLR4 was significantly higher in classical monocytes and nonclassical monocytes in comparison to the control group (p=0.019, and p≤0.0001, respectively). Besides, TLR4 expression was significantly up regulated in the preterm group compared to full-term in non-classical monocyte subset (p<0.0001). Moreover, the expression of TLR-4 in neutrophils from the preterm group was statistically higher than expression from the full-term labor and control groups (p<.0001 for both). Such findings highlight the important role of monocyte subsets and neutrophils in activating the innate immune system and initiating strong pro-inflammatory responses that induce preterm labor. Additionally, TLR4 and TLR2 expressions on non-classical monocytes may be used as a marker to assess the probability of preterm labor.
A brief overview of the entomofauna of lamellar beetles (Scarabaeidae) of the foothills of the Maly Chimgan (Republic of Uzbekistan)
Authors: Leontyev Vyachesla V. , Artanova Alina A. , Zhobborov Agzam M.
Published: July 2024

During July–August 2016, the entomofauna of lamellar-whiskered coleoptera was studied in the Republic of Uzbekistan, in the Bostanly District, in the foothills of the Maly Chimgan, in the vicinity of the village. Chimgan. During a short-term expedition in 2016, we identified 18 species of lamellate beetles belonging to 6 subfamilies (Aphodiinae, Cetoniinae, Dynastinae, Melolonthinae, Rutelinae, Scarabaeinae) and 10 tribes (Adoretini, Aphodiini, Cetoniini, Coprini, Gymnopleurini, Melolonthini, Oniticellini, Onitini, Onthophagini, Oryctini). Taxonomically, among these groups, the Onthophagini tribe contained the most species – 5 species (27,77%), Cetoniini tribe – 4 species (22,22%), Aphodiini tribe – 2 species (11,11%). One species (5,55%) included the tribes Adoretini, Coprini, Gymnopleurini, Melolonthini, Oniticellini, Onitini, Oryctini. By trophic specialization, coprophages prevailed (61,11%), followed by phytophages (33,33%), and aphages were less represented (5,55%). The identification of Melolontha hippocastani hippocastani (Fabricius, 1801) here can probably cause discussion, since according to S.I. Medvedev’s southern border of this species passed through northern Kazakhstan. Although it can be assumed that over a period of almost 70 years, the boundaries of the habitats of many species have changed significantly.
Accumulation of heavy metals and arsenic in plants in the vicinity of the Chadan coal deposit (Republic of Tuva)
Authors: Oorzhak Chochagai O. , Samdan Andrey M. , Kurbatskaya Svetlana S.
Published: July 2024

The content of copper, zinc, lead, cadmium and cobalt in plant samples from the vicinity of the Severny dump of the Chadansky coal mine in the Republic of Tuva was studied. Heavy metals in plant samples were determined by the Quantum-2mt atomic absorption spectrophotometer. Due to the extra-arid conditions, the studied area belongs to the zone of risky agriculture and there is developed cattle breeding. It was revealed that vegetation typical for steppe communities is developed on the territory of the Chadan coal deposit, represented by wormwood-cereal, grass-grass-wormwood, grass-wormwood-kovyl, wormwood-grass-grass steppes. In the dumps, deposits of different ages with small-scale, wormwood-cereal communities with typically steppe species are developed. For lead, cadmium and cobalt, the concentrations in vegetation samples from the CER and SWZ sites adjacent to the dump turned out to be close to their background values. The Cu content in the vegetation of the dump sites exceeds the natural content by 2–2,2 times, Zn – 2–2,7 times, Pb – 1,5 times. However, a comparison of the content of Cu, Cd, Zn, Pb, Co in vegetation from 2 sites of the Severny dump and the background territory with MDU for plant feeds showed that their concentrations in the studied samples are much lower than the maximum permissible level.
Zooplankton and macrozoobenthos of small reservoirs of the State Natural Reserve «Kologrivsky Les» named after M.G. Sinitsyn
Authors: Sirotina Marina V. , Sirotin Alexey L. , Sokolova Tatyana L. , Muradova Lyudmila V. , Sitnikova Olga N. , Yashneva Elena A.
Published: July 2024

The article presents the results of studies of zooplankton and macrozoobenthos of small reservoirs on the territory of the State Natural Reserve «Kologrivsky Les» named after M.G. Sinitsyn. The hydrochemical and hydrophysical parameters of small reservoirs are given. In summer, the highest biomass and abundance of zooplankton were observed for long-existing beaver ponds on streams. In autumn, among the studied small reservoirs, the highest biomass and abundance of zooplankton are characteristic of oxbow lakes. The highest biomass of benthos was noted in oxbow lakes, and its abundance was found in beaver ponds. An analysis of the ecological groups of zooplankton and benthos by type of nutrition was carried out. In autumn, the composition of zooplankton was marked by a predominance of vertical feeders and primary filter feeders in beaver ponds, primary filter feeders and predatory forms in ditches, primary filter feeders and vertical feeders in oxbow lakes, and secondary filter feeders, scrapers, detritivores and stand feeders in hollows in wetlands. The benthos of beaver ponds and oxbow lakes contains all six ecological groups of benthos based on feeding type. There are no collectors, obligate filter feeders or active predators in the ditches. Only soil ingesters were noted in the hollows. A number of indices have been calculated to characterize the structure of zooplankton.
Prospects of cotton growing in the Caspian provinces of Iran in the assessments of officials of the Russian Empire on the eve and during the First World War
Authors: Larin Andrey B.
Published: July 2024

The article is devoted to the assessment of the prospects for the development of cotton growing in the Astarabad and Mazanderan provinces of Qajar Iran by the statesmen of the Russian Empire on the eve and during the First World War. The pre-war years were characterized by the intensification of Russian policy in the region. Among other things, with the active participation of the consulate in Astarabad, the formation of large Russian land ownership in the Caspian provinces and the development of peasant resettlement in the region is taking place. Cotton was considered as one of the main promising crops for breeding in the established farms, while it was the most interesting from the point of view of solving Russia’s strategic tasks to ensure the country’s resource independence. This problem is one of the little-studied in the existing historiography. On the basis of archival and published sources, the views of officials of the Ministry of Foreign Affairs and the Resettlement Department on the problem of cotton growing are investigated. It is shown that due to the favorable climatic conditions of the region and its natural resources, the prospects for cotton cultivation for the Russian market looked promising. The connection in the ideas of the officials of the Resettlement Department of the success of cotton growing with the development of Russian peasant resettlement, the influence of the ideas of the "civilizing mission" of Russia on their considerations is also noted.
The Yen Bay Rebellion (1930) and internal security policy in French Indochina
Authors: Lyozin Alexander I.
Published: July 2024

The article contents an analysis of the French experience of anti-colonial struggle in the era of Interbellum in the Indochina region. Special attention is devoted to the degree and speed of the response of the French colonial administration and the metropolis to the events taking place. The article presents the characteristics of French military thought regarding the specifics of conducting combat operations against the rebels using aviation and native units. Attention is focused on the problem of the loyalty of the Vietnamese people, their attitude to French rule. The main fears of the French in connection with the growth of Vietnamese national identity as a threat to the colonial order are revealed. The importance of the events in Yen Bai is emphasized from the point of view of further measures by Paris to ensure internal security in the Indochina region. The changes in the national composition of the French colonial army in Indochina are shown. The uprising affected not only the army, but also the political police of France – «Sûreté». The work shows that the uprising did not receive universal support from the local population. The reaction of a part of French society to the events in Yen Bai is analyzed. Special attention is paid to the personality of Pierre Pasquier, Governor-General of Indochina, who personified the conservative part of the French colonial bureaucracy, whose attitude towards local peoples in the Interbellum era rather complicated relations between the metropolis and dependent territories. On the other hand, attention is drawn to the impact of the events in Yen Bai on changes in both the composition and leadership of the driving political force of the revolutionary struggle in Indochina. It was at this time that the National Party of Vietnam lost its leading position in the vanguard of the anti-colonial struggle to the Communist Party of Indochina.
Methodology of designing a professionogram of a technosphere safety specialist
Authors: Gorina Larisa N. , Denisova Oksana P. , Freze Tatyana Y. , Panishev Andrey L.
Published: July 2024

The training of specialists for industrial areas and individual industries implies the availability of professional competencies that allow them to perform functional duties efficiently and efficiently. The specifics of professional activity can be expressed by a list of competencies that describe the field of tasks of specialists, their knowledge, skills, competencies, requirements for a specialist, both in terms of theoretical knowledge and practical experience, and personal components necessary for the performance of duties. Is it possible today to talk about a certain set of competencies for a particular profession or activity? There are various types of descriptions of professional activities of specialists: job descriptions, qualification reference books, professional standards, models of specialists, occupational descriptions, professional or qualification structures. Such a variety of formats for describing a profession, type of activity implies their different content, depending on the goals, design tasks, expected result of the project, characteristics of the employee’s activity, data necessary for accounting and control of the result. The purpose of the professionograms is to describe the necessary and sufficient competencies for a particular specialist. Such a description becomes a roadmap for obtaining professional education, for activities, for professional retraining and certification of a specialist. The methodology of designing professionograms is based on an algorithmic approach that allows describing the universal process of developing a professionogram for a specific field of activity.
Career and educational trajectory of Bachelors of Applied Informatics at a regional university: aspects of design and implementation
Authors: Dobudko Tatiana V. , Makarov Sergey I. , Pugach Olga I.
Published: July 2024

This article analyzes a complex set of personnel training problems for the digital economy. The authors note that the mechanical increase in budget places in the system of higher and secondary vocational education is not enough to provide the IT segment of the labor market in Russia, which is related both to the quality of training of specialists and to the career expectations of graduates. The author’s definition of the student’s career and educational trajectory is given. As one of the possible solutions, an integrative-micromodular approach is proposed, the key element of which is the cooperation of the student, the university and potential employers in designing and implementing an effective career and educational trajectory for each student. The authors note significant differences in the goals, resources and strategies of federal, national and regional universities, while focusing on the latter. Using the example of bachelor’s degree training in the field of Applied Informatics 09.03.03, the issues of work and part-time work of students during the study period, the influence of this factor on the career and educational trajectory are analyzed in depth. Examples of the implementation of micromodules «career stage» in the disciplines of «Programming», «Databases», «Information Systems Design», «Software Engineering», «Data Analysis», «Cloud services», «Web programming» are considered. The strategy of using psychosemantics methods for recognizing and clarifying the image of a future profession, professional self-reflection and, possibly, professional trials is described.
Evaluation of the results of treatment of primary knee osteoarthritis using intra-joint synolis VA injection
Authors: Thai Phuc Tran
Published: July 2024

Evaluate the results and unwanted effects of intra-articular injection therapy of hyaluronic acid combined with sorbitol in the treatment of primary knee osteoarthritis. Subjects and methods: Prospective, interventional, controlled study with longitudinal follow-up on 101 patients with 151 knee osteoarthritis stages II and III according to Kellgren and Lawrence, divided into 2 groups: intervention group. Inject 1 tube of Synolis VA 80/160mg into the damaged knee joint, the control group was treated with oral medications Mobic, Viatril S. VAS, WOMAC scores, knee flexion amplitude in the intervention group improved significantly starting from week 4 and continued until week 12, statistically significantly better than the control group (p< 0.01). After 12 weeks of treatment, the VAS score decreased from 5.28 to 1.24, the rate of moderate/severe pain decreased from 100% to 6.8%, 39.2% had no pain, the overall WOMAC score decreased from 36.46. down to 12.27, the knee joint flexion amplitude increased by 19.46 ± 11.84 degrees, the rate of satisfaction and very satisfaction was 92.3% (p<0.01). No serious unwanted effects were encountered, 28.4% of knee joint tightness after injection, 12.2% of post-injection pain within 12-24 hours, 4.1% of joint effusion. Conclusion: Intra-articular injection therapy of hyaluronic acid combined with sorbitol has a fast pain relief effect, improves knee joint mobility better than the control group and is safe.
Exploring the binding affinity landscape of SARS-CoV-2 variants: A Computational Approach
Authors: Sharma Roma
Published: July 2024

The emergence of SARS-CoV-2 variants, like Beta, poses a challenge due to potential changes in viral infectivity and immune escape. This study employs computational tools to analyze the interaction between the Receptor Binding Domain (RBD) of the SARS-CoV-2 Beta variant and the human Angiotensin-Converting Enzyme 2 (ACE2) receptor. Additionally, the potential inhibitory effect of an S304 Fab antibody fragment on this interaction is investigated. Protein structures were visualized using RASMOL/PYMOL and validated with ERRAT/PROCHECK. Docking simulations with the CB-DOCK server were performed to predict the binding mode and affinity of S304 Fab to the Beta variant RBD- ACE2 complex. Our results provide insights into the structural features of the Beta variant RBD-ACE2 interaction and predict potential binding sites for the S304 Fab fragment. The findings contribute to understanding viral entry mechanisms for the Beta variant and suggest S304 Fab as a likely candidate for further investigation as a therapeutic strategy.
Efektivitas Penggunaan Strategi Copy The Master terhadap Keterampilan Menulis Cerpen Siswa Kelas XI SMAN 1 Pangkep
Authors: Haris Muh Fahrezi , Ningsih Wahyu , Tolla Achmad
Published: July 2024

Penelitian ini berfokus pada keterampilan menulis cerpen smenggunakan strategi copy the master pada siswa kelas XI SMAN 1 Pangkep. Penelitian ini bertujuan untuk membuktikan efektivitas penggunaan strategi copy the master terhadap keterampilan menulis cerpen siswa kelas XI SMAN 1 Pangkep. Metode yang digunakan dalam penelitian ini adalah kuantitatif dengan jenis penelitian Pra Eksperimen (Pre-Eksperimental). Desain yang digunakan pada penelitian ini adalah one group pretest-posttest. Teknik pengumpulan data yang digunakan dalam peneletian ini menggunakan hasil tes belajar.  Tes hasil belajar yang dimaksud adalah tes keterampilan menulis cerpen sebelum menggunakan strategi Copy the Master (pretest) dan tes keterampilan menulis cerpen setelah menggunakan strategi Copy the Master (Posttest). Data dalam penelitian ini menggunakan perhitungan statistik deskriptif dan inferensial dengan cara menghitung hasil belajar siswa, peningkatan hasil belajar siswa, normalitas data dan pengujian hipotesis. Dari hasil analisis data dan pengujian hipotesis menggunakan paired sampel t test dapat disimpulkan penggunaan strategi copy the master efektif terhadap keterampilan menulis cerpen siswa kelas XI SMAN 1 Pangkep.
Pengaruh Teknik Pengandaian Diri terhadap Kemampuan Menulis Puisi Siswa Kelas VIII SMP Negeri 2 Baranti Kabupaten Sidenreng Rappang
Authors: Bella Bella , Rasyid Rustam Efendy , Khalik Suhartini
Published: July 2024

Penelitian ini bertujuan untuk mengetahui pengaruh penerapan teknik pengandaian diri terhadap kemampuan menulis puisi siswa kelas VIII SMP Negeri 2 Baranti Kabupaten Sidenreng Rappang tahun pelajaran 2022. Populasi penelitian ini adalah siswa kelas VIII SMP Negeri 2 Baranti, Kabupaten Sidenreng Rappang, yakni 47 siswa. Sampel dalam penelitian ini sebanyak 47 siswa yang dibaki kedalam dua kelompok yaitu 23 orang kelompok ekspresimen dan 23 orang kelas kontrol. Metode pengumpulan data yang digunakan adalah observasi, dokumentasi dan tes (menulis puisi). Data yang diperoleh kemudian diolah dengan analisis statistik  inferensial (Uji-t).  Hasil penelitian menunjukkan bahwa kelompok siswa yang diajar menulis puisi dengan menerapkan teknik pengandaian diri memperoleh nilai rata-rata 80,00 sedangkan kelompok siswa yang diajar tanpa menerapkan teknik pengandaian diri memperoleh nilai rata-rata 60,79. Setelah dianalisis dengan uji t.test, hasilnya menunjukkan nilai empiris lebih besar dari nilai tabel yaitu 7,619  lebih besar daripada taraf signifikan 5% (2,014) dan pada taraf signifikan 1% (2,689) pada df 45. Berdasarkan hasil analisis data disimpulkan bahwa prestasi belajar siswa dalam menulis puisi menggunakan teknik pengandaian diri lebih baik daripada prestasi belajar siswa yang tidak menggunakan teknik pengandaian diri di kelas VIII SMP Negeri 2 Baranti, Kabupaten Sidenreng Rappang. Hal tersebut menandakan bahwa penerapan teknik pengandaian diri berpengaruh terhadap kemampuan menulis puisi siswa kelas VIII SMP Negeri 2 Baranti, Kabupaten Sidenreng Rappang.
Lanskap Linguistik Pulau Kambuno Kabupaten Sinjai (Tinjauan Etnografi James P. Spradley 1997)
Authors: Rustan Megawati , Nensilianti Nensilianti , Mahmudah Mahmudah
Published: July 2024

Bahasa ruang publik atau disebut lanskap linguistik (LL) yang semakin marak saat ini, namun banyak masyarakat belum memahami makna dari bahasa yang terpajang. Penelitian ini bertujuan untuk mendeskripsikan bentuk dan makna LL di Pulau Kambuno dengan menggunakan metode deskriptif kualitatif melalui dua belas tahapan penelitian model James P. Spradley 1997. Data dalam penelitian ini adalah tanda-tanda lingual dan non lingual pada LL. Sumber data penelitian ini LL atau papan reklame yang terpajang di Pulau Kambuno. Data dikumpulkan dengan metode teknik potret, perekaman, dan wawancara. Hasil peneltian kategori bentuk bahasa di Pulau Kambuno menunjukkan bentuk frasa berdasarkan jenis kelas kata meliputi nomina, verba, adjektiva, adverbia, numeralia; bentuk kata meliputi kata dasar, kata berimbuhan, kata majemuk; kata ulang; bentuk kalimat meliputi kalimat majemuk bertingkat hubungan alat, kalimat majemuk bertingkat hubungan cara, kalimat majemuk bertingkat hubungan waktu, kalimat majemuk bertingkat hubungan atribut; bentuk akronim; warna, jenis font, penggunaan media, logo. Sedangkan hasil makna bahasa ditemukan makna konseptual, makna tematik, dan makna sosial.
Perempuan Minang dalam Novel Perempuan Bathin Karya A. R. Rizal
Authors: Yusup Helmi , Lukman Lukman , Gusnawaty Gusnawaty
Published: July 2024

Penelitian ini bertujuan menjelaskan refleksi perempuan Minangkabau dalam novel Perempuan Batih karya A. R. Rizal. Penelitian ini menggunakan pendekatan struktural model Teeuw. Metode yang digunakan dalam penelitian ini adalah metode kualitatif. Pengumpulan data dilakukan melalui studi pustaka dengan cara membaca buku-buku serta tulisan-tulisan yang memiliki hubungan dengan objek penelitian. Jenis data yang akan digunakan dalam penelitian ini terbagi dua yaitu data primer dan data sekunder. Hasil penelitian mendeskripsikan penggambaran perempuan Minangkabau dalam novel Perempuan Batih terbagi menjadi dua yaitu penggambaran perempuan Minangkabau dulu dan penggambaran perempuan Minangkabau sekarang. Perempuan Minangkabau dulu digambarkan sebagai perempuan yang memegang teguh adat istiadat, penyayang dan setia, tegar dan mandiri. Perempuan Minang sekarang digambarkan sebagai perempuan modern, mudah putus asa, dan kehilangan jati diri. Penggambaran perempuan Minangkabau tersebut dikaji melalui penokohan.
Analisis Kesalahan Ejaan Pada Makalah Mahasiswa Semester V Prodi Pendidikan Bahasa Indonesia
Authors: Podding Kamal , Ecca Suleha , Aswadi Aswadi , Lanta Jumiati , Desiani Nur Fitria
Published: July 2024

Tujuan penelitian  untuk menganalisis kesalahan penggunaan Ejaan pada makalah mahasiswa semester V Prodi Pendidikan Bahasa Indonesia di Universitas Muhammadiyah Sidenreng Rappang. Metode penelitian menggunakan pendekatan kualitatif yang fokus meneliti penggunaan tanda baca dan Ejaan kebahasaan. Data diperoleh dari makalah mahasiswa semester V Prodi Pendidikan Bahasa Indonesia. Data diperoleh dengan teknik dokumentasi dokumen resmi internal, kemudian data diolah dengan teknik analisis deskriftif . Hasil penelitian. Hasil penelitian menunjukkan kesalahan berbahasa dari segi ejaan (huruf kapital, huruf miring, dan  tanda baca). Berdasarkan data kesalahan ejaan yang ditemukan, masih banyak kesalahan penulisan tanda koma dalam pendahuluan makalah mahasiswa letak kesalahan tidak menggunakan tanda koma sebelum kata dan seharusnya jika lebih dari dua unsur maka harus diberi sisipan tanda baca koma. Menurut panduan hal tersebut tidak dibenarkan karena tidak mengikuti panduan penulisan yang benar.
Perpektif Mahasiswa terhadap Profil Dosen Bahasa Indonesia pada Era Society 5.0
Authors: Kurnia Maya Dewi , Afriyanti Riskha , Rosmaya Elin , Frananda Muhamad
Published: July 2024

Sebagai tenaga profesional, dosen harus memiliki empat kompetensi yang meliputi kompetensi pedagogik, profesional, sosial, dan kompetensi kepribadian. Selain itu era society 5.0 dosen dituntut memiliki kecakapan teknologi. Kompetensi tersebut menentukan mutu akademik. Penelitian ini menjelaskan persepsi mahasiswa terhadap profil dosen pendidikan bahasa dan sastra Indonesia di era society 5.0. Adapun metode penelitian yang digunakan adalah metode penelitian kualitatif. Subjek dari penelitian ini seluruh mahasiswa tingkat dua pendidikan bahasa dan sastra Indonesia Universitas Swadaya Gunung Jati yang berjumlah 60 mahasiswa. Data dikumpulkan melalui angket selanjutnya dianalisis dengan model Miles and Huberman.  Dari penelitian tersebut diketahui kompetensi pedagogik, kompetensi professional, kompetensi sosial, dan kepribadian dosen pendidikan bahasa dan sastra Indonesia Universitas Swadaya Gunung Jati berdasarkan perpektif mahasiswa tergolong baik.
Membangun Solidaritas melalui Turnamen Esports Mobile Legends di Komunitas Gaming Pedesaan
Authors: Fitrianto Rizal Akbar , Editya Arda Surya , Husaini Arinda Putri , Ekavanda Wirahandy , Ferdyansyah Moch. Arief
Published: July 2024

Turnamen Esports Mobile Legends di komunitas pedesaan menunjukkan potensi besar dalam membangun solidaritas dan semangat kompetitif. Penelitian ini bertujuan untuk mengeksplorasi dampak turnamen terhadap komunitas gaming pedesaan. Peserta terbatas dari kalangan pelajar SD-SMP, kompetisi ini menyoroti kolaborasi antargenerasi, potensi esports dalam mempersatukan komunitas, serta kebutuhan akan pengembangan yang lebih luas untuk mencapai dampak yang lebih besar. Penelitian ini bertujuan untuk mengeksplorasi dampak turnamen terhadap komunitas gaming pedesaan. Metode penelitian melibatkan observasi langsung dan wawancara dengan peserta serta penyelenggara turnamen. Hasil menunjukkan peningkatan interaksi sosial dan motivasi antar generasi di desa.
Mobile Legends Esports tournaments in rural communities show great potential in building solidarity and competitive spirit. This research aims to explore the impact of tournaments on rural gaming communities. Limited to elementary and middle school students, this competition highlights intergenerational collaboration, the potential of esports in uniting communities, and the need for broader development to achieve greater impact. This research aims to explore the impact of tournaments on rural gaming communities. The research method involves direct observation and interviews with participants and tournament organizers. The results show increased social interaction and motivation between generations in the village.
Gestión del talento humano y su incidencia en la calidad del servicio del hotel “Noches de París” del cantón Vinces, año 2023.
Authors: Granados Rivas Yanila Esther , Fernández Romero Tani Irlanda , Chu Zheng Kaven Alberto , Patiño Uyaguari Javier Leonardo
Published: July 2024

La investigación titulada " Gestión del talento humano y su incidencia en la calidad del servicio en el Hotel Noches de París" tiene como objetivo analizar cómo la gestión del talento humano influye en la calidad de los servicios ofrecidos a los clientes en el Hotel Noches de París ubicado en el cantón Vinces. La adecuada administración del personal es crucial para el éxito operativo y la satisfacción de los clientes, siendo la atención personalizada y la excelencia en el servicio aspectos clave. En este estudio, se realizó una revisión exhaustiva de la literatura relacionada con la gestión del talento humano y la calidad del servicio. La investigación, que combina enfoques cualitativos y cuantitativos, se basó en métodos de análisis inductivo, deductivo y de análisis. Se emplearon técnicas como entrevistas y dos encuestas, una dirigida a los empleados y otra a los usuarios del hotel, y se llevó a cabo un análisis de confiabilidad utilizando el coeficiente Alfa de Cronbach en los instrumentos. Los resultados obtenidos indican que la gestión del talento humano es un factor crítico para alcanzar los objetivos organizacionales, pero presenta debilidades como la falta de políticas internas y manuales de funciones, así como deficiencias en la capacitación que afectan el rendimiento de los trabajadores. En conclusión, se identificaron procesos inadecuados en la gestión del talento humano en el hotel.
Estrategias integradas para la mejora de la sostenibilidad ambiental
Authors: TayHing-Cajas Carolina , Díaz-Ponce Mariela , Guerrero-Chuez Norma , Herrera-Feijoo Robinson J.
Published: July 2024

Este estudio abordó la sostenibilidad urbana en la ciudad de Valdez, provincia de Esmeraldas, Ecuador, utilizando un enfoque no experimental. Se recopilaron datos de diversas fuentes, incluyendo encuestas exhaustivas, observaciones de campo y el Plan de Desarrollo y Ordenamiento Territorial (PDyOT). A través de un análisis de componentes principales (ACP), se seleccionaron 11 variables discriminantes de un total de 26, explicando el 98,50% de la variabilidad. La "compacidad absoluta" resultó ser la variable más influyente, destacando la importancia de la proximidad de áreas verdes (250 m² a 400 m²) para mejorar la conectividad y la disponibilidad de espacios verdes por habitante. El estudio también identificó componentes críticos relacionados con el consumo de energía, la planificación urbana y la actividad comercial. Un análisis de árbol de decisión con seis nodos resaltó la relevancia de la "compacidad absoluta" y la proximidad de áreas verdes en la sostenibilidad urbana. Además, se observó que la densidad de servicios comerciales contribuye más significativamente a la sostenibilidad que la densidad de espacios verdes. Los resultados subrayan la necesidad de una planificación urbana integrada que priorice la gestión de recursos, la conservación de áreas verdes y la eficiencia energética. En conclusión, este estudio proporciona una base sólida para abordar los desafíos de sostenibilidad urbana en Valdez, promoviendo acciones concretas y compromisos a largo plazo. La implementación de estrategias basadas en los hallazgos puede guiar efectivamente las políticas para mejorar la calidad de vida y la sostenibilidad en la ciudad.
PERANCANGAN DAN INTEGRASI IOT PADA SISTEM KENDALI AIR KOLAM DENGAN METODE FUZZY BERDASARKAN PH DAN TURBIDITY BERBASIS MIKROKONTROLER
Authors: H.D Ni Ketut , Mahardani Joni
Published: July 2024

Dalam budidaya ikan lele sangat penting untuk memperhatikan kualitas air kolam, diantaranya tingkat keasaman air kolam, dan tingkat kekeruhan pada kolam. Akan tetapi beberapa peternak ikan lele mulai disibukkan dengan aktivitas lainnya untuk waktu yang cukup lama sehingga pengontrolan kualitas air tidak dapat dikontrol lagi. Tujuan dari penelitian ini yaitu untuk menghasilkan sebuah prototipe atau perancangan sistem monitoring dan kendali kadar keasaman dan kekeruhan pada air kolam yang dapat berjalan secara otomatis dan dapat dimonitoring dari jarak jauh menggunakan internet.
 
Penelitian ini bertujuan untuk membuat prototipe kontrol kendali pH air kolam ikan lele dengan menggunakan Arduino  Uno sebagai mikrokontroler dan sensor pH serta sensor turbidity. Penelitian ini menggunakan metode fuzzy logic control. Perhitungan metode fuzzy dilakukan menggunakan dua parameter input yaitu pH air dan kekeruhan air. Output dari hasil perhitungan fuzzy berupa timer, yaitu lama waktu yang diperlukan untuk menguras air kolam. Metode fuzzy Sugeno dipilih untuk mengendalikan derajat keasaman air sesuai kebutuhan ikan lele dengan cara menguras air dengan durasi yang ditentukan dari hasil perhitungan fuzzy Sugeno sebagai titik pusat z. Hasil pembacaan sensor pH dan turbidity akan ditampilkan di LCD dan kemudian oleh Aduino akan dikirim ke ESP8266 untuk diteruskan ke pengguna melalui aplikasi Blynk. 
 
Berdasarkan penelitian yang telah dilakukan, sistem penyesuaian pH otomatis berhasil dibangun dan dapat diakses melalui aplikasi Blynk. Keakuratan sensor pH dapat membaca nilai derajat keasaman dengan rata-rata error sebesar 2,053% sehingga dapat dikatakan sensor bekerja dengan cukup baik karena sensor tetap dapat membaca perubahan derajat keasaman dalam air yang berbeda meskipun dengan perubahan yang cukup kecil. Sensor turbidity yang digunakan juga mempunyai keandalan yang cukup baik dengan rata-rata error 8,057%. Pengujian perhitungan metode Sugeno dilakukan dengan membandingkan hasil perhitungan fuzzy logic control dengan hasil perhitungan Matlab.
SISTEM PENTANAHAN DRIVEN GROUND PADA GARDU DISTRIBUSI ULP SOREANG
Authors: Fauzia Haz  , Muhammad Ilhammawardi
Published: July 2024

Pada sistem tenaga listrik dibutuhkan suatu proteksi yang dapat menjaga dan juga mengamankan pemakai dan juga peralatan listrik maka diperlukan sebuah sistem yaitu sistem pentanahan pada gardu distribusi listrik. Sistem pentanahan yang terdapat pada jaringan distribusi bertujuan untuk pengaman langsung terhadap manusia dan juga peralatan jika terjadi gangguan tanah atau terjadi kebocoran arus yang diakibatkan kegagalan isolasi, tegangan lebih pada peralatan jaringan distribusi dan petir juga bisa menghasilkan arus gangguan dan tegangan lebih. Bahaya dari gangguan akibat petir bisa diatasi jika sistem pentanahannya baik yaitu memiliki nilai resistansi pentanahan yang kurang dari ≤1 ohm supaya arus dari gangguan akibat petir bisa langsung mengalir ke dalam tanah. Pada beberapa gardu distribusi di ULP Soreang sering mengalami masalah yang dikarenakan nilai resistansi nya lumayan tinggi yaitu 34.2 Ω, 25 Ω , 41.5 Ω, 6.42 Ω, dan 10.98 Ω. Cara yang dipakai adalah dengan sistem driven gound yaitu dengan cara menanamkan earthing rod atau elektroda batang ke dalam tanah untuk memper kecil nilai tahanan supaya bisa menghantarkan arus yang berlebih hingga dapat mengamankan peralatan listrik dan menjaga keselamatan manusia yang menggunakannya. Hasil dari penelitian bisa dijadikan referensi dalam penentu tindakan pencegahan gangguan penyaluran secara dini ataupun sebagai bahan untuk menentukan pemasangan pentanahan pada gardu distribusi secara tepat, supaya sistem pentanahan ULP Soreang UP3 Majalaya bisa terjaga keandalannya.
Avaliação clínica em paciente portador de lesão degenerativa avançada poliarticular associado a compressão radicular tratado com células tronco e bloqueios: relato de caso
Authors: Mundim Neto Joaquim Pedrosa , Costa Matheus André Ribeiro da , Oliveira Bruna Almeida Pires Franco de , Vitória Estela Urzeda , Xavier Larissa Rebeca Luz , Sudré Tamyris Mendes de Faria , Silva Deyvison José da , Oliveira Rodrigo Franco de
Published: July 2024

As doenças degenerativas comprometem de forma irreversível e progressiva as funções vitais, causando danos a células, tecidos e órgãos, e são caracterizadas por incapacitação funcional e intenso sofrimento, agravados por compressões radiculares na coluna vertebral. Anteriormente associadas aos idosos, agora afetam um grupo mais amplo devido ao aumento da longevidade e à necessidade de manter a capacidade laboral. O tratamento não cirúrgico da osteoartrite (OA) inclui medicamentos como analgésicos e anti-inflamatórios não esteroides (AINEs), que aliviam dor e reduzem a inflamação, mas têm possíveis efeitos colaterais. Novos medicamentos, como inibidores seletivos da COX-2, estão sendo investigados. A medicina regenerativa, utilizando células-tronco e novos fármacos como o ácido hialurônico, oferece novas perspectivas, especialmente para pacientes com contraindicações aos tratamentos convencionais. Em resposta, a OARSI adota novas recomendações baseadas em estudos de alta qualidade. As doenças degenerativas causam danos progressivos e irreversíveis às funções vitais, resultando em deterioração da qualidade de vida e capacidade laboral. Novas abordagens, como a medicina regenerativa e a engenharia de tecidos, estão sendo exploradas para oferecer tratamentos menos invasivos e mais eficazes. A medicina regenerativa utiliza células-tronco e novos fármacos para tratar doenças crônicas e lesões agudas, promovendo a regeneração de tecidos. A colaboração interdisciplinar é crucial para avançar nessas áreas e identificar novas direções para a investigação e prática clínica. Este relato demonstra os benefícios de uma técnica viável e menos invasiva, com resultados promissores, especialmente para pacientes com contraindicações aos procedimentos cirúrgicos convencionais. Não há conflito de interesse envolvido no desenvolvimento deste relato de caso.
Uso de células tronco associado a decanoato de nandrolona no tratamento de osteoartrite
Authors: Mundim Neto Joaquim Pedrosa , Costa Matheus André Ribeiro da , Oliveira Bruna Almeida Pires Franco de , Vitória Estela Urzeda , Sudré Tamyris Mendes de Faria , Xavier Larissa Rebeca Luz , Camilo Victor Fernandes , Oliveira Rodrigo Franco de
Published: July 2024

A osteoartrite (OA) é uma doença degenerativa crônica caracterizada pela degradação da cartilagem articular. Clinicamente, a OA manifesta-se por dor articular, crepitação, rigidez matinal e atrofia muscular. As abordagens terapêuticas incluem mudanças dietéticas, redução de peso, limitações de atividades, analgésicos, anti-inflamatórios, infiltrações com corticosteroides e intervenções cirúrgicas. O manejo conservador controla a dor, melhorar a mobilidade e a qualidade de vida através de controle de peso, fisioterapia e medicamentos, embora esses tratamentos tenham efeitos limitados a longo prazo. Aspiração de medula óssea surge como uma terapia celular promissora por ser menos invasiva e mais eficaz, utilizando células-tronco autólogas. Pesquisas exploram o uso do Decanoato de Nandrolona no tratamento da osteoporose e lesões ósseas, sugerindo que ele estimula o crescimento ósseo e a regeneração celular. A síndrome metabólica (SM) também contribui para a OA ao causar inflamação sistêmica. A cartilagem articular é um tecido alto conteúdo de água e compostos orgânicos como colágeno tipo II e proteoglicanas. Condrócitos regulam homeostase da matriz através de fatores de crescimento e citocinas, enquanto enzimas e citocinas como IL-1 e FNT-a promovem a degradação da matriz. Células-tronco mesenquimais (MSCs) têm alta plasticidade e podem se diferenciar em vários tipos de tecidos, oferecendo perspectivas promissoras para a terapia celular. A terapia com células-tronco oferece potencial regenerativo significativo, mas requer mais pesquisas e regulamentações. É essencial um diagnóstico abrangente e uma abordagem terapêutica que considere o indivíduo como um todo, educando os pacientes sobre a OA e incentivando mudanças de hábitos para uma melhor gestão da doença.
Acolhimento institucional e o direito ao cuidado diante do abandono infantil: um estudo de caso da “Casa de Nazaré” em Arcoverde/PE
Authors: Cartaxo Maria Stephanie Barros , Santos Mariana Macêdo
Published: July 2024

O abandono de crianças no Brasil aparece, na atualidade, como uma das alegações mais recorrentes nos registros de violações dos direitos das crianças, notadamente do direito ao cuidado, por parte das agências envolvidas na proteção infantil. Nesse aspecto, foram estabelecidas medidas de proteção de amparo com o intuito de reduzir os danos graves causados às crianças e adolescentes em situação de abandono, como os acolhimentos institucionais, objetos deste estudo. Buscou-se, por meio da atuação do acolhimento institucional “Casa de Nazaré”, compreender em que medida instituições filantrópicas e religiosas, são capazes de ressignificar as dores e garantir o direito ao cuidado de crianças e adolescentes em situação de abandono infantil. No que tange a metodologia, trata-se de pesquisa bibliográfica e documental, com abordagem qualitativa, na qual se utilizou como instrumento de coleta de dados entrevistas em profundidade. Em sede de resultados, consta-se que as próprias crianças trazem em suas falas todo o amparo e afeto voltados a elas que a Casa de Nazaré proporciona, como a educação, alimentação e atendimento com equipes multidisciplinares, tudo isso como tradução do direito ao cuidado. O diferencial desta casa de acolhimento é o fomento da espiritualidade e da fé, o que mostrou-se efetivo na ressignificação do sofrimento das meninas acolhidas.