bluuebunny/crossref_metadata_2025 huggingface dataset:
Literature Study: Types of Social Support in Adolescents with Unwanted Pregnancy
Authors: Fauziah Sifva , Ermiati Ermiati , Sari Eka Afrima
Published: June 2021

Unwanted Pregnancy in adolescents can create a negative impact on adolescents who experience it. Management of Unwanted Pregnancy by providing social support are needed to reduce the perceived impact. The limited articles on the types of social support for adolescents experiencing Unwanted Pregnancy made this literature study aimed to find out the types of social support that can be provided to adolescents who experience Unwanted Pregnancy. This research method was scoping review using search engines such as EBSCOHost, Google Scholar, and PubMed. The keywords used were "adolescents" OR "teenagers" OR "young adults" OR "student" AND "unwanted pregnancy" AND "social support". The result of article search based on inclusion and exclusion criteria had found 6 articles. Critical appraisal was done using a JBI critical appraisal checklist with a result of 6 selected articles which stated as eligible sources to be used as source of references in this literature study. The result of the review of 6 articles with content analysis found that there were 10 types of social support that can be provided to adolescents who experience Unwanted Pregnancy. The types of social support were providing information, counseling, communication, emotional support, financial support, assistance, accountability, appreciation, providing shelter and providing educational facilities. Recommendations for further research are expected to do a further analysis on types of social support that has been found, so that it can be implemented to reduce the impact on adolescents with Unwanted Pregnancy.
Quality of Sleep Among Elderly with Hypertension at Werdha Institusion in West Java Province
Authors: Handayani Wening , Lukman Mamat , Mambang Sari Citra Windani
Published: June 2021

Elderly are particularly vulnerable groups that is prone to experiencing a decline in health related to a physiological decline. Vulnerability such as changes in structure of blood vessel walls lead to increased incidence of hypertension. Moreover, in uncontrolled conditions, elderly with hypertension can suffer symptoms of sleeping disorder, changes of sleep pattern that triggers the increasing of blood pressure and affect sleep quality. The purpose of this descriptive quantitative research was to describe the sleep quality of elderly with hypertension based on seven components of sleep quality assessment.Â  The research design used a descriptive quantitative with a cross-sectional approach. The study was conducted at Ciparay and Garut Elderly Social Rehabilitation Centre, with number of the sample obtained 37 elderlies who were elected by total sampling technique. The result of this study showed that 89,2% of respondents had poor sleep quality. Several conditions that stimulate poor sleep quality in the elderly come from high blood pressure which causes sleep disturbances, thereby changing several sleep components such as short sleep duration less than 6 hours, sleep latency 15-30 minutes, decreased sleep efficiency below 85%, and activity dysfunction in daytime.Â  Future research is expected to be able to modify sleep quality measuring instruments that are specifically used to measure the quality of sleep for people with hypertension.
Javanese Elderly’s Responses of Stres Due to Neglect by Families: A Phenomenological Study
Authors:   Universitas Muhammadiyah Pekajangan Pekalongan,, Aryati Dyah Putri
Published: June 2021

Elderly neglect is a global issue in the health sector. In terms of Javanese culture, neglect of the elderly relates closely to relationship between parents and children. This kind of relationship is shown by the respect of children to their parents as a form of filial piety. Every child should have a sense of responsibility to take care of his parents in the future so that no parent will be neglected. Neglect that happens to the elderly for a long time can cause negatif impacts, one of them is stress. The purpose of this study was to describe the stress responses experienced by Javanese elderly due to neglect. This research method was descriptive qualitative phenomenology. The research sample was 7 Javanese elderlies who experienced stress and neglect. The sample was chosen by a purposive sampling technique. The research data were gathered by interview guideline, field note, and tape recorder. Interview method is semi-structure interview method and observation. The collected data were analyzed by using a Colaizzi analysis. The results of the study can be classified into two themes, the positive and the negative responses of Javanese elderly to stress due to family neglect. The role of community nurses is crucial in making promotion and preventive intervention related to neglect of the elderly. In addition, the development of intervention such as supportive group discussion is needed to reduce stress levels in the elderly.
Effect of Woolen Cloth to Maintain Temperature 39Â°C of Crystaloid Fluid Ringer Lactate at Room Temperature 18Â°C
Authors: Fitriana Helna , Wahid Abdurrahman , Nasution Tina Handayani , Negara Gia Eka
Published: June 2021

Fluid resuscitation with 39áµ’C is one of the main therapies for hypovolemic (hemorrhagic) shock patients to prevent complications. In this time, we already have tools to keep the fluid warm, but not all health services have these tools.Â  To find out the effectiveness of using woolen cloth against the temperature of Ringer Lactate 39Â°C crystalloid fluid at room temperature 18Â°C. This study used a pre-experimental method, with a static group comparison approach, with 4 Ringer Lactate liquid samples divided into 2 groups, namely groups using wool cloth and those not using woolen cloth. Data collected through observation sheets. Data analyzed using the Mann Whitney test. With this p value (0.00001) <Î± (0.05), it can be concluded that there is a significant difference between the use of woolen cloth and those that do not use woolen cloth. The woolen cloth is effective to slow down the decrease in temperature of the crystalloid liquid Ringer Lactate 39áµ’C at room temperature 18áµ’C. The difference in temperature changes in the Ringer Lactate crystalloid fluid is influenced by several things including humidity, ambient temperature, and additional material used.
The Impact of Technology-Enabled Care Coordination in a Complex Mental Health System: A Local System Dynamics Model
Authors: Iorfino Frank , Occhipinti Jo-An , Skinner Adam , Davenport Tracey , Rowe Shelley , Prodan Ante , Sturgess Julie , Hickie Ian B
Published: June 2021

Background

Prior to the COVID-19 pandemic, major shortcomings in the way mental health care systems were organized were impairing the delivery of effective care. The mental health impacts of the pandemic, the recession, and the resulting social dislocation will depend on the extent to which care systems will become overwhelmed and on the strategic investments made across the system to effectively respond.

Objective

This study aimed to explore the impact of strengthening the mental health system through technology-enabled care coordination on mental health and suicide outcomes.

Methods

A system dynamics model for the regional population catchment of North Coast New South Wales, Australia, was developed that incorporated defined pathways from social determinants of mental health to psychological distress, mental health care, and suicidal behavior. The model reproduced historic time series data across a range of outcomes and was used to evaluate the relative impact of a set of scenarios on attempted suicide (ie, self-harm hospitalizations), suicide deaths, mental health–related emergency department (ED) presentations, and psychological distress over the period from 2021 to 2030. These scenarios include (1) business as usual, (2) increase in service capacity growth rate by 20%, (3) standard telehealth, and (4) technology-enabled care coordination. Each scenario was tested using both pre– and post–COVID-19 social and economic conditions.

Results

Technology-enabled care coordination was forecast to deliver a reduction in self-harm hospitalizations and suicide deaths by 6.71% (95% interval 5.63%-7.87%), mental health–related ED presentations by 10.33% (95% interval 8.58%-12.19%), and the prevalence of high psychological distress by 1.76 percentage points (95% interval 1.35-2.32 percentage points). Scenario testing demonstrated that increasing service capacity growth rate by 20% or standard telehealth had substantially lower impacts. This pattern of results was replicated under post–COVID-19 conditions with technology-enabled care coordination being the only tested scenario, which was forecast to reduce the negative impact of the pandemic on mental health and suicide.

Conclusions

The use of technology-enabled care coordination is likely to improve mental health and suicide outcomes. The substantially lower effectiveness of targeting individual components of the mental health system (ie, increasing service capacity growth rate by 20% or standard telehealth) reiterates that strengthening the whole system has the greatest impact on patient outcomes. Investments into more of the same types of programs and services alone will not be enough to improve outcomes; instead, new models of care and the digital infrastructure to support them and their integration are needed.
Acceptability of Research and Health Care Visits During the COVID-19 Pandemic: Cross-sectional Survey Study (Preprint)
Authors: Ross Kathryn M , Hong Young-Rock , Krukowski Rebecca A , Miller Darci R , Lemas Dominick J , Cardel Michelle I
Published: June 2021

BACKGROUND

The COVID-19 pandemic has had a widespread impact on attendance in biomedical research and health care visits.

OBJECTIVE

This study aimed to identify when and how American adults might feel comfortable about resuming in-person research and health care visits.

METHODS

Cross-sectional questionnaire data were collected from 135 adults (age: median 48 years; women: n=113, 83.7%; White participants: n=92, 68.2%) who were engaged in health-related research.

RESULTS

More than half of the respondents (65/122, 53.3%) felt that the COVID-19 pandemic positively affected their desire to participate in research. Although 73.6% (95/129) of respondents also indicated a willingness to attend in-person health care visits while Centers for Disease Control and Prevention (CDC) guidelines are implemented, 85.8% (109/127) indicated a willingness to attend in-person, outdoor visits, and 92.2% (118/128) reported a willingness to attend drive-through visits (with CDC guidelines implemented during both visit types). Videoconferencing was the most preferred format for intervention visits; however, adults over the age of 65 years preferred this format less than younger adults (P=.001).

CONCLUSIONS

Researchers and clinicians should continue to provide opportunities for continuing the conduction of remote-based interventions while enforcing CDC guidelines during in-person visits.
Fatty Acid Composition, Antinutritional Factors, and Oligosaccharides Concentration of Hawaijar (An Ethnic Fermented Soyfood of India) As Affected by Genotype and Bacillus Subtilis Strain
Authors: Devi L. Sophia , Kumar Vineet , Rani Anita , Tayalkar Trupti , Mittal Priyanka , Anshu Aseem Kumar , Singh Thangjam Anand
Published: June 2021

Hawaijar is an ethnic fermented soy product from the North-East region of India. The information on the effect of soybean genotype and the Bacillus subtilis strain used for inoculation for preparing the product on the fatty acid composition, the level of antinutritional factors, such as Kunitz trypsin inhibitor (KTI) and Bowman-Birk inhibitor (BBI), and oligosaccharides is not available. In the present study, Hawaijar was prepared from two soybean genotypes using two different strains of Bacillus subtilis and investigated for the concentration of the above-mentioned biomolecules. The results showed the significant effect of genotype used on oleic, linoleic, and α-linolenic acid of the product. KTI and BBI were found absent in Hawaijar prepared from these two genotypes and two strains. Flatulence-inducing factors like raffinose and stachyose were found in very low concentration irrespective of genotype and strain. Retention of sweetness-imparting sucrose and maltose concentration in Hawaijar was genotype-dependent.
Movimiento del eco de precipitación en radar del Huracán Donna
Authors: Senn H. V.
Published: June 2021

Analizando películas de varios radares del mismo tiempo en el Huracan Donna, se obtuvieron datos consistentes en casi 3,800 ecos de precipitación que se combinaron para ilustrar, por primera vez, el campo completo de movimientos de eco relativamente simultáneos en casi todas las alturas y azimutes de un huracán. EI campo de los movimientos de eco en radar del Huracan Donna, el 9 de septiembre de 1960, se comparó después con vientos locales de superficies y otro y también el 9 y 10 de septiembre con datos de movimientos de eco de precipitación en radar en los Huracanes Edna 1954, Connie, Diana e lone 1955, Audrey 1957 y Daisy y Helene 1958. Cuando se elimina Ia velocidad del centro de Ia tormenta, puede comprobarse que los máximos del movimiento de eco relativo resultante tienen Iugar con más frecuencia a Ia izquierda de esa dirección. Se discuten posibles explicaciones para este comportamiento del movimiento de eco.
Configuraciones sinóptico-climatológicas asociadas con ciclogénesis tropical Noratlántica
Authors: Haggard William H.
Published: June 2021

Se seleccionaron algunos grupos de situaciones ciclogenéticas tropicales noratlánticas y se desarrollaron compuestas de configuraciones sinópticas asociadas, haciendo que cada grupo fuera lo más internamente homogéneo posible respecto a tiempo estacional y localización geográfica de Ia ciclogénesis. Se hizo un esfuerzo deliberado para obtener heterogeneidad entre los grupos y homogeneidad dentro de los mismos grupos. Se desarrollaron configuraciones compuestas de presión en Ia superficie y a 500 mb de altura y temperatura de divergencia y vorticidad a esos niveles y en Ia superficie, basta un espesor de 500 mb para los grupos de orígenes de tormenta seleccionados. Se estudiaron en Ia misma forma grupos similares de datos en que no hubo desarrollo de tormenta. Se compararon configuraciones., genéticas y no-genéticas para varias áreas genéticas y varias partes de Ia temporada de tormentas.
Las bandas de huracanes como predictoras
Authors: Freeman, JR. John C.
Published: June 2021

Se revisa una teoría de vientos geociclostróficos en aire húmedo se postula una relación entre viento y calles de nubes o bandas de huracanes. La aparición de las bandas desde satélites y en radar, atribuye al movimiento, estructura e intensidad de las tormentas.
Sobre relaciones de la variación de onda larga en la gravedad respecto a corteza y manto superior
Authors: Kaula William M.
Published: June 2021

Las correlaciones más evidentes de campo de gravedad con la actividad geológica parecen ser:1) anomalías positivas sobre toda la fosa Circum-Pacífica y cordones de arcos isleños, a la vez que en áreas de reciente extrusión.2) anomalías muy pequeñas sobre altos oceánicos de velocidad de dispersión relativamente nítida y sobre áreas quietas cuya actividad geológica cesó recientemente.3) anomalías negativas sobre cordilleras de plegamiento y compresión y sobre áreas de glaciación reciente.
El campo geomagnético del mar epicontinental argentino
Authors: Vila Fernando
Published: June 2021

Mediciones de intensidad magnética sobre la llanura costera sumergida de Argentina se describen y discuten en sus resultados; que se presentan en mapas y perfiles. Además, se proporciona información geológica general sobre las áreas de medición.
A computational procedure for the determination of the optical air-mass
Authors: Muhlia V. Agustin , Galindo E. Ignacio , Lemoyne L. Luis
Published: June 2021

In this report a computation in Algol language for the optical air mass is presented. The method contains the reduction of the observation time, a daily correction for the solar declination and the trigonometric equation. By means of a modified Bemporad table with 900 entries the relative air mass is obtained. The running time for each observation is only 1/60".
On the evaluation of atmospheric turbidity parameters from actinometric data
Authors: Lal Murari
Published: June 2021

Bajo condiciones promedio de turbidez se obtuvieron grandes variaciones en los parámetros de turbidez atmosférica (exponente de longitud de onda α y coeficiente de turbidez (β) adoptando la técnica usual de Angstrom, empleando la representación gráfica de valores de intensidad en bandas espectrales amplias. Con la finalidad de mejorar la exactitud en la determinación del parámetro de turbidez α se lleva a cabo la integración numérica de los datos actinométricos del espectro solar y la transmisibilidad de los filtros clásicos de Schott. Este trabajo demuestra que las amplitudes del parámetro de turbidez α así derivados, son reales y dan valores más exactos de turbidez en la atmósfera.
Acerca del ángulo de influjo y su importancia en el desarrollo de los huracanes
Authors: Serra Castelán Sergio
Published: June 2021

Los resultados de varios experimentos de un modelo numérico de un huracán, se presentan en este trabajo. El modelo se ha formulado en el sistema σ (p/po), es un modelo balanceado y tiene cuatro capas principales y una capa friccional y la red radial es de distribución no uniforme, tiene mayor resolución cerca del centro. El ángulo de influjo en la capa friccional se determina por la distribución dada por una espiral recíproca en la parte central y el criterio de la existencia de divergencia positiva en el resto de esta capa. La relación entre esta formulación y la "clásica", que usa el coeficiente de arrastre, se discute y se prueba que el uso de un coeficiente de arrastre dado es equivalente a usar un ángulo de influjo determinado. El ángulo de influjo tiene una distribución que da un valor máximo. Varios valores de este máximo se usaron en el modelo y se demuestra que un mínimo de 4°, para el ángulo máximo, es necesario para producir desarrollo en el modelo. En un experimento mediante variación del ángulo máximo de influjo un estado estable fue obtenido. Los distintos campos que se obtuvieron después de 90 horas de integración se presentan y todos ellos indican una distribución que se apega mucho a la realidad.
Computational Drug Repurposing Resources and Approaches for Discovering Novel Antifungal Drugs against Candida albicans N-Myristoyl Transferase
Authors: Hussain Afzal , Verma Chandan Kumar
Published: June 2021

Candida albicans is a yeast that is an opportunistic fungal pathogen and also identified as ubiquitous polymorphic species that is mainly linked with major fungal infections in humans, particularly in the immunocompromised patients including transplant recipients, chemotherapy patients, HIV-infected patients as well as in low-birth-weight infants. Systemic Candida infections have a high mortality rate of around 29 to 76%. For reducing its infection, limited drugs are existing such as caspofungin, fluconazole, terbinafine, and amphotericin B, etc. which contain unlikable side effects and also toxic. This review intends to utilize advanced bioinformatics technologies such as Molecular docking, Scaffold hopping, Virtual screening, Pharmacophore modeling, Molecular dynamics (MD) simulation for the development of potentially new drug candidates with a drug-repurpose approach against Candida albicans within a limited time frame and also cost reductive.
The Role of Expenditure on Research and Development (R&D) in Promoting Economic Growth and Competitiveness
Authors:   University of Latvia, Jekabsone Sandra , Sproģe Ilze , Kristone Solvita
Published: June 2021

Development of science and research is fundamental for economic growth, as well as the competitiveness of a country. Taking into account the potential decrease of EU funds financing and the limited amount of Latvian national financing, it is necessary to ensure that the efficiency of the use of financing is maintained and raised further. The aim of the study is to evaluate the impact of the EU funds funding activities of 2007–2013 and 2014–2020 on science, research and innovation support activities of Latvian research institutions, as well as the sustainability of the results obtained within the support activities, taking into account the measures planned to support research, development and innovation during the programming period of EU funds 2021–2027. The results of the research show that expenditure in research and development (R&D) in Latvia is small and dependent on European Structural Funds (currently R&D investments are mainly attracted by EU funds), which is not a sustainable solution for R&D development, considering that this financing and its availability are periodic and in the future. This requires consistent long-term public and private (business) R&D investment.
O reendereçamento de obras literárias por meio do projeto gráfico: 'Fita Verde no Cabelo', de Guimarães Rosa | The readressing of literary works via graphic projects: Fita 'Verde no Cabelo', by Guimarães Rosa
Authors: Luersen Paula , Inoue Gabriela Narumi
Published: June 2021

ResumoEste artigo analisa o reendereçamento da obra Fita verde no cabelo: nova velha estória ao público infantojuvenil. Em 1992, o conto de Guimarães Rosa foi reeditado pela Nova Fronteira, contando com novo projeto gráfico e com as ilustrações de Roger Mello, em edição dedicada ao público jovem. Além de observar o modo como a obra busca o diálogo com esse público em níveis textuais e imagéticos, o estudo concentra-se na análise das ilustrações. Verifica-se a hipótese de que as imagens, em vez de apenas facilitarem a leitura para um público específico, expandem o sentido da obra original contemplando todos os públicos. Como resultado, demonstra-se a potência das imagens e sua capacidade de enriquecer a experiência de leitura do conto de Rosa.Palavras-chave: João Guimarães Rosa. Reendereçamento. Ilustração. AbstractThis article analyzes the readdressing of the work Fita verde no cabelo: nova velha estória to youth literature. In 1992, Guimarães Rosa's short story was reissued by Nova Fronteira. The book had a new graphic project by Roger Mello. This study focuses not only on how the story is looking for dialogue with the young audience in written-text and visual-image levels, but also in the analysis of illustrations. We verify the hypothesis that the images do not facilitate the reading process for a specific audience, for they are in turn ways to expand the meanings of the original work. The potential of those images is demonstrated along with their capacity to enrich the reading experience of Rosa's short story.Keywords: João Guimarães Rosa. Readdressing. Illustration.
Muragens | Wallucinating
Authors: Maciel Matheus De Simone
Published: June 2021

Este ensaio visual consiste em um registro do trabalho “Muragens“, inserção de vídeos curtos da Praia do Forte (Cabo Frio, RJ), realizada às vésperas do verão de 2020 em painéis de LED destinados à propaganda, na Avenida Presidente Itamar Franco — centro de Juiz de Fora, MG. "Muragens" enquanto gesto pretende acender uma discussão acerca da influência das imagens na construção da vida no espaço público. Especialmente sob contexto de isolamento social, qual é o poder da simples inserção de uma paisagem como o mar, tão cobiçado nessa época do ano, sob as vidas dos frequentadores da cidade?
Intergenerational, Interspecies, Familial Networks and Friendships
Authors: Vastavikta  , moomal shekhawat
Published: June 2021

We at SEA believe that the pandemic has a granularity of meta, non-linear narratives that become useful in making sense of the relational complexities of the pandemic and society. Thus, we set out to collect stories of fears, joys, agilities, fragilities, friendships, networks, collectives, home, work, infrastructures, entrepreneurship, privileges, marginalizations, migrations, desperation, gender, equity, etc. The glossary as a method became useful to reflect on this granularity of experiences and account for slippages during these times. These spatio-temporal stories, when read together or as individual instances produce a new sense of the emergent contemporary. This framework also allows us to speculate on the kind of world we will inhabit once the storm has passed.

We draw on multiple readings to bring out the nuances and patterns of social life produced in a pandemic. This we hope would allow us to collectively reflect on the restructured ideas of the self, the collective, society, space, and time.

When people were locked in, new solidarities and friendships emerged that allowed society to stay afloat and people to hold each other. This elaborates on the COVID pandemic, and the experience around family friends, and other relationships.
The Phenomenon of Danger
Authors: Vastavikta Bhagat  , moomal shekhawat
Published: June 2021

We at SEA believe that the pandemic has a granularity of meta, non-linear narratives that become useful in making sense of the relational complexities of the pandemic and society. Thus, we set out to collect stories of fears, joys, agilities, fragilities, friendships, networks, collectives, home, work, infrastructures, entrepreneurship, privileges, marginalizations, migrations, desperation, gender, equity, etc. The glossary as a method became useful to reflect on this granularity of experiences and account for slippages during these times. These spatio-temporal stories, when read together or as individual instances produce a new sense of the emergent contemporary. This framework also allows us to speculate on the kind of world we will inhabit once the storm has passed.

We draw on multiple readings to bring out the nuances and patterns of social life produced in a pandemic. This we hope would allow us to collectively reflect on the restructured ideas of the self, the collective, society, space, and time.

The phenomenon of Danger wears many faces. With each set of different circumstances, it changes its guise and triggers new emotional responses in us. As we continue to live more, our experience of Danger gathers more meaning. ‘Playing with Danger’ is a portrait gallery of sorts, portraits of Danger, each portrait painted in a new light, from a different perspective.
Feasibility of Implementing a Web-based Tool Built from Pharmacy Claims Data (e-MEDRESP) to Monitor Adherence to Respiratory Medications in Primary Care
Authors: Yousif Alia , Lemière Catherine , Forget Amélie , Beauchesne Marie-France , Blais Lucie
Published: June 2021

Objectives: e-MEDRESP is a novel web-based tool that provides easily
interpretable information on patient adherence to asthma/chronic
obstructive pulmonary disease medications, using pharmacy claims data.
This study investigated the feasibility of implementing e-MEDRESP in
primary care. Materials and Methods: In this 16-month prospective cohort
study, e-MEDRESP was integrated into electronic medical records.
Nineteen family physicians and 346 of their patients were enrolled.
Counters embedded in the tool tracked physician use during the
follow-up. Patient/physician satisfaction with e-MEDRESP was evaluated
though telephone interviews and online questionnaires. The capacity of
e-MEDRESP to improve adherence was explored using a pre–post analysis.
Results: Overall, 252 patients had at least one medical visit during
follow-up. e-MEDRESP was consulted by 15 (79%) physicians for 85 (34%)
patients during clinic visits. Seventy-three patients participated in
telephone interviews; 84% reported discussing their medication use with
their physician; 33% viewed their e-MEDRESP report and indicated that
it was easy to interpret. The physicians reported that the tool
facilitated their evaluation of their patients’ medication adherence
(mean ± standard deviation rating: 4.8 ± 0.7, on a 5-point Likert
scale). Although the pre–post analysis did not reveal improved
adherence in the overall cohort, adherence improved significantly in
patients whose adherence level was <80% and patients
prescribed inhaled corticosteroids (26.9% [95% CI 14.3%–39.3%])
or long-acting muscarinic agents (26.4% [95% CI 12.4%–40.2%]).
Conclusions: e-MEDRESP was successfully integrated in clinical practice.
It could serve as a powerful tool to help physicians monitor their
patients’ medication adherence.
RORγt+Foxp3+ regulatory T cells in the regulation of autoimmune arthritis
Authors: Furuyama Kotona , Kondo Yuya , Shimizu Masaru , Yokosawa Masahiro , Segawa Seiji , Iizuka Akira , Tanimura Reona , Tsuboi Hiroto , Matsumoto Isao , Sumida T
Published: June 2021

RORγt+Foxp3+ regulatory T (Treg) cells, known as T regulatory 17 cells
(Tr17 cells), are a novel subset of Treg cells, which have the potential
to regulate the development of experimental autoimmune encephalomyelitis
(EAE) thorough a specific repression of T helper 17 (Th17) cell mediated
inflammation. However, the function of Tr17 cells the development of
other autoimmune diseases such as autoimmune arthritis remains unclear.
Collagen induced arthritis (CIA) was found to be prolonged in
Foxp3creRORγtfl/fl mice, in which Tr17 cells were deleted, compared with
Foxp3wtRORγtfl/fl mice. Tr17 cells were significantly increased in ankle
joints compared with draining lymph nodes after the onset of arthritis.
CC chemokine receptor 6 (CCR6) was up-regulated on Tr17 cells compared
to RORγt negative Treg cells. CD25, cytotoxic T-lymphocyte antigen 4
(CTLA-4), glucocorticoid-induced TNF-receptor (GITR), and inducible
T-cell co-stimulator (ICOS) expression was also up-regulated on Tr17
cells compared to RORγt negative Treg cells. IL-10-producing cells and
Blimp-1+ cells were increased in Tr17 cells compared to RORγt-Treg
cells. Tr17-enriched Treg cells significantly suppressed proliferation
of conventional T cells compared with CCR6-Treg cells. Tr17 cells
increased during the clinical course of CIA and accumulated in inflamed
joints. These cells expressed CD25, CTLA4, GITR, and ICOS molecules and
up-regulated Blimp-1 and over-produced IL-10. Moreover, CCR6+ Treg cells
significantly suppressed cell proliferation. Taken together, it appears
that Tr17 cells play a crucial role in the regulation of autoimmune
arthritis.
Benefits of Career Guidance for Secondary Vocational School Students -Evaluation of a Pilot Program
Authors:   Czech University of Life Sciences Prague, Votava Jiri , Jirsakova Jitka ,   Czech University of Life Sciences Prague
Published: June 2021

Although career guidance in the Czech Republic is officially perceived as a priority of the education system, guidance support is not provided equally at all types of schools and on all levels of the education system. For example, we register insufficient support for students at secondary vocational schools. As previous research by the authors of the article has shown, it seems that once a young person decides to pursue a career, the effort of the school system to pay further attention to career guidance will also decrease. This paper is aimed to suggest a new program for career education, counselling and training, afterwards to pilot it at three secondary vocational schools, and with the help of action research to collect and to evaluate experience from the school practice. The empirical part of this article consists of three research phases. First, a baseline analysis was performed using mixed data resources (questionnaire survey among students, interviews with school counsellors and document analysis). In the second phase, a new career guidance program was proposed. Finally, the program was tested at three vocational schools in the years 2019 and 2020. Using action research design, the researchers gathered evidence and identified the benefits of new counselling activities. Based on these results, proposals for further improvement and implementation of career guidance and education at secondary vocational schools were submitted.
Rank partition functions and truncated theta identities
Authors: Merca Mircea
Published: June 2021

In 1944, Freeman Dyson defined the concept of rank of an integer partition and introduced without definition the term of crank of an integer partition. A definition for the crank satisfying the properties hypothesized for it by Dyson was discovered in 1988 by G. E. Andrews and F. G. Garvan. In this paper, we introduce truncated forms for two theta identities involving the generating functions for partitions with non-negative rank and non-negative crank. As corollaries we derive new infinite families of linear inequalities for the partition function p(n). The number of Garden of Eden partitions are also considered in this context in order to provide other infinite families of linear inequalities for p(n).
Analytical solutions for the effective viscoelastic properties of composite materials with different shapes of inclusions
Authors: Thai Minh-Quan , Nguyen Sy-Tuan , Nguyen Thanh-Sang , Mai Phu-Son
Published: June 2021

This paper aims to model the effect of different shapes of inclusions on the homogenized viscoelastic properties of composite materials made of a viscoelastic matrix and inclusion particles. The viscoelastic behavior of the matrix phase is modeled by the Generalized Maxwell rheology. The effective properties are firstly derived by combining the homogenization theory of elasticity and the correspondence principle. Then, the effective rheological properties in time space are explicitly derived without using the complex inverse Laplace?Carson transformation (LC). Closed-form solutions for the effective bulk and shear rheological viscoelastic properties, the relaxation and creep moduli as well as the Poisson ratio are obtained for the isotropic case with random orientation distribution and different shapes of inclusions: spherical, oblate and elongate inclusions. The developed approach is validated against the exact solutions obtained by the classical inverse LC method. It is observed that the homogenized viscoelastic moduli are highly sensitive to different shapes of inclusions.
Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota That Protects From Metabolic Diseases
Authors: Lécuyer Emelyne , Le Roy Tiphaine , Gestin Aurélie , Lacombe Amélie , Philippe Catherine , Ponnaiah Maharajah , Huré Jean-Baptiste , Fradet Magali , Ichou Farid , Boudebbouze Samira , Huby Thierry , Gautier Emmanuel , Rhimi Moez , Maguin Emmanuelle , Kapel Nathalie , Gérard Philippe , Venteclef Nicolas , Garlatti Michèle , Chassaing Benoit , Lesnik Philippe
Published: June 2021

Excess chronic contact between microbial motifs and intestinal immune cells is known to trigger a low-grade inflammation involved in many pathologies such as obesity and diabetes. The important skewing of intestinal adaptive immunity in the context of diet-induced obesity (DIO) is well described, but how dendritic cells (DCs) participate in these changes is still poorly documented. To address this question, we challenged transgenic mice with enhanced DC life span and immunogenicity (DChBcl-2 mice) with a high-fat diet. Those mice display resistance to DIO and metabolic alterations. The DIO-resistant phenotype is associated with healthier parameters of intestinal barrier function and lower intestinal inflammation. DChBcl-2 DIO-resistant mice demonstrate a particular increase in tolerogenic DC numbers and function, which is associated with strong intestinal IgA, T helper 17, and regulatory T-cell immune responses. Microbiota composition and function analyses reveal that the DChBcl-2 mice microbiota is characterized by lower immunogenicity and an enhanced butyrate production. Cohousing experiments and fecal microbial transplantations are sufficient to transfer the DIO resistance status to wild-type mice, demonstrating that maintenance of DCs’ tolerogenic ability sustains a microbiota able to drive DIO resistance. The tolerogenic function of DCs is revealed as a new potent target in metabolic disease management.
Efficacy and Safety of Dulaglutide 3.0 mg and 4.5 mg Versus Dulaglutide 1.5 mg in Metformin-Treated Patients With Type 2 Diabetes in a Randomized Controlled Trial (AWARD-11)
Authors: Frias Juan P. , Bonora Enzo , Ruiz Luis Nevarez , Li Ying G. , Yu Zhuoxin , Milicevic Zvonko , Malik Raleigh , Bethel M. Angelyn , Cox David A.
Published: June 2021

Objective: To compare efficacy and safety of dulaglutide at
doses of 3.0 and 4.5 mg versus 1.5 mg in patients with type 2 diabetes inadequately
controlled with metformin.

Research
Design and Methods: Patients were
randomized to once weekly dulaglutide
1.5 mg, 3.0 mg, or 4.5 mg for 52 weeks. Primary objective was superiority of
dulaglutide 3.0 mg and/or 4.5 mg over 1.5 mg in HbA1c reduction at 36 weeks. Secondary superiority
objectives included change in body weight.
Two estimands addressed efficacy objectives: treatment-regimen estimand
(regardless of treatment discontinuation or rescue medication) and efficacy
estimand (on treatment without rescue medication) in all randomized patients.

Results: Mean
baseline HbA1c
and BMI in randomized patients (N=1842) was 8.6% (70 mmol/mol) and 34.2 kg/m2,
respectively. At 36 weeks, dulaglutide
4.5 mg provided superior HbA1c reductions compared to 1.5 mg (treatment-regimen
estimand: -1.77 vs ‑1.54% [-19.4 vs -16.8 mmol/mol], estimated treatment
difference [ETD] -0.24% (-2.6 mmol/mol); P<0.001; efficacy estimand: -1.87
vs ‑1.53% [‑20.4 vs -16.7 mmol/mol], ETD -0.34% (-3.7 mmol/mol);
P<0.001). Dulaglutide 3.0 mg was
superior to 1.5 mg on HbA1c reduction using the efficacy estimand (ETD -0.17% [-1.9 mmol/mol];
P=0.003) but not the treatment-regimen estimand (ETD -0.10% [-1.1 mmol/mol ];
P=0.096). Dulaglutide 4.5 mg was superior to 1.5 mg for weight loss at 36 weeks
for both estimands (treatment-regimen estimand: -4.6 vs -3.0 kg, ETD -1.6 kg;
P<0.001; efficacy estimand: -4.7 vs -3.1 kg; ETD -1.6 kg; P<0.001). Common adverse events through 36 weeks included
nausea (1.5 mg, 13.4%; 3 mg, 15.6%; 4.5 mg, 16.4%) and vomiting (1.5 mg, 5.6%;
3 mg, 8.3%; 4.5 mg, 9.3%).

Conclusion: In patients with type 2 diabetes inadequately
controlled on metformin, escalation from dulaglutide 1.5 mg to 3.0 mg or 4.5 mg
provided clinically relevant, dose-related reductions in HbA1c and body weight with a similar safety profile.
Project-Based Learning in Teaching EFL Writing: An Analysis of the Effect on The 5 Dimensions of Writing
Authors: Wardani Ni Komang Sri , Artini Luh Putu , Ramendra Dewa Putu
Published: June 2021

Education has begun to see important constructivism in recent years to create effective teaching/learning strategies. There are several teaching models which are constructed based on constructivist theory. One of those models is Project-Based Learning. This study aims to analyze the effect of Project-Based Learning on students’ writing skill of grade IX students. This study implied embedded mixed method design, in which the quantitative data were considered as the main data. The data were collected through guided interview, observation, open-ended questionnaire, and writing test. Paired-sample t-test was used to analyze whether or not there is a significant difference in students’ writing skill before and after being taught using PBL, and Manova was used to analyze how project-based learning affected students’ writing skill in term of content, organization, structure, vocabulary, and mechanic. While the qualitative data were analyzed descriptively. The result showed that Project-Based Learning has significant effect on students’ English writing skill and it also affected the students’ writing skill in term of content, organization, structure, vocabulary, and mechanic (sig. =0.000 < α =0.05). Project-Based Learning also revealed potentially promotes students’ critical thinking, creativity, collaborative work, and enhances teacher’s satisfaction in teaching. In general, it can be concluded that Project-Based Learning significantly improves students’ writing skill of the grade IX students.
THE OPPORTUNITY TO ACCESS BETTER INFORMATION TECHNOLOGY
Authors: Mardison Eri
Published: June 2021

Children are born without being able to choose a number of factors that are attached to them. This is in fact unfair to him in supporting his future. HOI exists to calculate a number of factors that cause imbalance and how much inequality should be reallocated. The usage of cellphone has covered 63.86 percent. The inequality that must be reallocated is 8.76 percent. Per capita income and residence are the dominant influencing factors. In the case of cellphone ownership, the coverage was still 33.12 percent, with an inequality reallocation of 17.05 percent. Per capita income and residence are the dominant factors. Access coverage on new computers reached 17.35 percent with reallocation of inequalities reaching 28.87 percent. Per capita income, residence and certificate of household head are the dominant factors. Meanwhile internet access has covered 35.02 percent with inequality reallocation reaching 17.85 percent. Per capita income, residence and certificate of household head are the most dominant things. An understanding of reality is very important in taking online policies against children that happen to be implemented during the Covid-19 period and possibly afterward.
COMPARING THE EFFECTIVENESS OF ASSAY FORMULATION FROM VARIOUS TRADITIONAL PLANTS AS PEDICULICIDE AGAINST Pediculus humanus capitis
Authors: Sari Desy Rosalina , Pratama Iman Surya , Tresnani Galuh
Published: June 2021

Pediculosis capitis is an infection with a fairly high incidence in children. Plants that contain eugenol, as frangipani (Michelia champaca L.), ceylon ironwood (Mesua ferrea L.), cinnamon (Cinnamomum burmannii), and sugar apple (Annona squamosa L.) have potential as an alternative pediculicide. This study aimed to compare the effect of traditional formulation of each plant with in vitro assay. The effectiveness of in vitro pediculicide was assessed from the post- immersion mortality time of the traditional formulation, permethrin 1% as the positive control and coconut oil as the negative control. The mechanism was observed using histopathological observation. The percentage of mortality time of lice was analyzed using One-Way ANOVA of SPSS 16. Histopathological aspects and infestation decrease were presented descriptively. This study took place for about 3 months and was conducted in Mataram University, West Nusa Tenggara. The results showed that frangipani leaves had the optimum pediculicide effect because the highest efficacy demonstrated by frangipani leaves formulation revealed the effect lower than permethrin 1% (LT: 350 minutes). In observation of histopathology, frangipani leaves formulation indicated the presence of anoxia similar to permethrin 1%.
MÚLTIPLOS OLHARES SOBRE A DOR CRÔNICA: O CASO DA FIBROMIALGIA
Authors: Silva Alan Camargo
Published: June 2021

Resenha de: MATTOS, R. S. (Org.). Dor crônica e fibromialgia: uma visão interdisciplinar. Curitiba: CRV, 2019.
Hospital Premises as a Potential Reservoir of Antimicrobial Resistance
Authors:   Department of Microbiology, SGT Medical College Hospital and Research Institute, Gurugram, Haryana, India, Chattopadhya Debasish
Published: June 2021

Soil in hospital premises can be a potential reservoir of organisms with Antimicrobial Resistance (AMR) due to their spread from hospital environment including pre-treated hospital waste. Thus, studying AMR in the soil samples from hospital premises at periodic interval could be helpful in monitoring the trend of its load and spectrum in hospital environment. Prevalence of Extended-Spectrum Beta-Lactamase (ESBL), carbapenemase and New Delhi Metallo-Beta-Lactamase (NDM) varieties of AMR were estimated in Escherichia coli and Klebsiella pneumoniae as indicator organisms in surface soil samples from hospital premises viz. hospital grounds and pedestrian tracks in relation to the pre-monsoon and post-monsoon seasons at an interval of four years between 2014 and 2018. There was significant increase in the prevalence of ESBL (mainly CTX-M variety), carbapenemase and NDM varieties of AMR in isolates from soil samples collected from hospital premises during post-monsoon season compared to pre-monsoon isolates regardless of the year of sampling although monsoon season did not affect the prevalence of AMR in clinical samples processed during the same period. There was gradual rise in resistance to other antibiotics viz. co-trimoxazole, tetracycline, fluoroquinolones and amoxyclav in soil samples collected from hospital premises during the four years interval. Prevalence of various categories of AMR were higher in samples collected during the post-monsoon season compared to prevalence in clinical isolates from hospital attending population during the corresponding period regardless of the year of sampling. Increasing prevalence of various categories of AMR recorded in hospital premises could indicate inadequate containment measures towards prevention of their spread from hospital environment warranting adaption of requisite measures for prevention.
Cikkismertetés: A testtömegindex és az összhalálozás, illetve az okspecifikus halálozás összefüggései [Article review: Association of body mass index with overall and cause-specific mortality]
Authors: Wolher Veronika
Published: June 2021

Az egyén tápláltsági állapotát leíró testtömegindex-ről (BMI) ismeretes, hogy szoros kapcsolatban áll az összhalálozással, de eddig kevés tanulmány bizonyult elég nagy esetszámúnak ahhoz, hogy megbízhatóan vizsgálja a BMI és az okspecifikus halálozási kimenetelek széles skálájának összefüggéseit.
Az egészségvédelmi feladatok színtéralapú megközelítése [The setting-based approaches of health promotion activities]
Authors: Juhász Gábor
Published: June 2021

Színtérnek nevezhető a mindennapi tevékenységekhez kapcsolódó hely vagy társadalmi közeg, amelyben a környezeti, szervezeti és személyes tényezők az egészségre és a jóllétre hatást gyakorolnak. A színtér-megközelítésű egészségfejlesztés előnye, hogy az emberek jóllétét elősegíteni kívánó minden szakmai szándék a színterek keretei között megjelenhet, és egyazon folyamat részeként járulhat hozzá az életminőség javításához. Az Egészségügyi Világszervezet (World Health Organization, WHO) a színtéralapú megközelítést először az „Egészséges Városok” (Healthy Cities) program kezdeményezésekor használta. A tapasztalatokat felhasználva ezt követően további színtereken is szerveződtek egészségfejlesztési tevékenységek. Az elmúlt három évtized tapasztalatai igazolták, hogy az egészségvédelmi feladatok színtéralapú szervezése integratív és multiszektorális együttműködést biztosító megoldást jelenthet számos színtér esetében.
The Analysis of Semiotic Signs on Forest Fires’ Posters
Authors: Pratiwi Desak Putu Eka , Vina Widiadnya I Gusti Ayu , Emi Puspita Sari Ni Luh
Published: June 2021

Forest fires are one of the global issues and need global concern. A campaign through forest fire posters on social media is a way to spread a message all over the world to prevent forest fires and save the earth from disaster. This study aims to discover the meaning of verbal and nonverbal signs used on forest fire posters. Verbal signs are about the text, either words or sentences while nonverbal signs are about pictures. The use of these two signs on a poster is meant to make people understand the message within it. The data were taken from three selected forest fire posters. The data were collected by observation method. The data were analyzed by a qualitative method using the theory of Semiotic by Barthes (1998) and supporting theory by Wierzbicka (1996). The finding shows that both verbal and nonverbal signs have important purposes such as giving some information about the impact of forest fires on nature and human life as well as warning people to be more responsible and aware of this global issue.