bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening and characterization of antibiotic producing bacteria from rhizospheric soil against fungal phytopathogens
Authors: Sharma Sonam , Walia Abhishek
Published: December 2023

In this study, antagonistic bacteria were isolated from rhizospheric soil collected from Himachal Pradesh (i.e., Solan and Hamirpur) and Punjab (i.e., Jalandhar and Pathankot). Sixty- eight bacteria were isolated and screened for antifungal activity against Botrytis oryzae, Aspergillus flavus, and Fusarium oxysporum. Three isolates, i.e., S7, S57, and S51, showed maximum inhibition for antifungal activity by using the agar streak method and were further selected for in vitro characterization. In vitro antifungal antibiotic study by using agar diffusion assay of isolates, i.e., S7, S57, and S51 at O.D. 2.0 showed maximum inhibition of 99% against Botyritis oryzae, Fusarium oxysporum, and Aspergillus flavus after seven days of incubation. Antibiotic assays using cell-free supernatant of antagonistic bacterial isolates, i.e., S7 and S57, showed complete inhibition at 10% against Botyritis oryzae and Fusarium oxysporum, whereas isolate S51 showed complete inhibition at 20% against Aspergillus flavus. The bacterial isolates were partially identified based on morphological and biochemical characteristics. The selected antagonistic bacterial isolates S7 and S57 appeared to be similar to Bacillus sp. and S51 to Actinomycete sp. Thus, the present study concludes that these bacterial isolates could serve as proficient biocontrol inoculants in the integrated management of soil-borne diseases in different crops under natural environmental conditions.
Prevalencia de dislipidemia y lipodistrofia en niños con infección VIH y tratamiento antirretroviral. Instituto Nacional de Salud del Niño, 2007
Authors: Angulo Valderrama Diana , Castillo Diaz María E.
Published: December 2023

Introducción: Debido a los avances en la patogénesis de la infección por VIH y el uso de terapia antirretroviral, han cobrado mayor importancia los efectos adversos a largo plazo. Las alteraciones metabólicas y la redistribución de la grasa corporal se describen entre los más frecuentes en la población pediátrica. Objetivos: Determinar la prevalencia de dislipidemia y lipodistrofia, y la frecuencia de presentación de factores asociados en niños con infección VIH del Instituto Nacional de Salud del Niño que reciben tratamiento antirretroviral de gran actividad (TARGA).

Metodología: Estudio descriptivo, transversal, prospectivo, observacional. Se incluyeron niños con infección por VIH atendidos en consultorio externo de Infectología, que se encontraban recibiendo TARGA, con un mínimo de 6 meses. Se revisó la historia clínica para consignar el tratamiento, los antecedentes y los resultados de los exámenes de laboratorio (perfil lipídico, recuento de linfocitos CD4 y carga viral). La anamnesis y el examen físico se realizaron en una consulta única asignándose la presencia o ausencia de características clínicas de lipodistrofia. Se compararon los grupos para determinar si existen diferencias en edad, sexo, estadio de la enfermedad, carga viral y duración del tratamiento antirretroviral.

Resultados: Se incluyeron 38 niños entre 1 y 15 años. La prevalencia de dislipidemia y lipodistrofia fue de 52.63%. El 65.79% presentó sólo dislipidemia: 1/38 (2.63%) con hipercolesterolemia, 20/38 (52.63%) con hipertrigliceridemia y 4/38 (10.53%) con dislipidemia mixta. El 63.16% presentó sólo lipodistrofia: 3/38 (7.89%) con lipoatrofia periférica, 8/38 (21.05%) con lipohipertrofia central y 13/38 (34.21%) con lipodistrofia combinada. La frecuencia de dislipidemia fue mayor en niños de sexo masculino (p=0.05) y la frecuencia de lipodistrofia fue mayor en niños con carga viral detectable (p=0.02).

Conclusiones: La prevalencia de dislipidemia y lipodistrofia en la población estudiada fue de 52.63%. La hipertrigliceridemia y la lipodistrofia combinada fueron las alteraciones más frecuentes. La dislipidemia fue más frecuente en niños de sexo masculino y la lipodistrofia en niños con carga viral detectable.
Factores de riesgo para neumonia asociada a ventilador
Authors: Becerra V. Rosario , Tantaleán D. José , León P. Rosa
Published: December 2023

La neumonía asociada a ventilador (NAV) es la segunda causa más importante de infecciones intrahospitalarias (IIH) en niños. Asimismo se asocia a alta mortalidad, morbilidad y costos en pacientes de unidades de cuidados intensivos (UCI).

Objetivos: Determinar los factores de riesgo y desenlaces en niños con neumonía asociada a ventilador.

Material y Métodos: Estudio de casos y controles. La muestra estuvo constituida por niños con diagnóstico de NAV hospitalizados en UCI del Instituto Nacional de Salud del Niño (INSN), entre los meses de junio 2006 a junio 2007. En cada niño se identificó el diagnóstico de ingreso, y se evaluaron los siguientes factores de riesgo: transporte fuera de UCI, re-intubación, RCP, transfusiones, uso de inotropos, uso de esteroides, antibióticos, nutrición parenteral, uso de bloqueadores H2, sedación, relajación, catéter venoso central, síndrome genético, EPOC, cardiopatía congénita, convulsiones, quemaduras, neutropenia, toracocentesis, traqueostomía, condición de post- operados. Para el análisis estadístico se utilizaron las pruebas de chi cuadrado y U de Mann Whitney, así como el SPSS versión 13.

Resultados: De 313 niños intubados, 241 permanecieron con ventilación mecánica (VM) > 48 horas, y 27 de ellos (11.2 %) desarrollaron NAV. Los 27 niños con diagnóstico de NAV fueron comparados con 54 controles pareados por edad y sexo. La edad promedio de los niños estudiados fue 31.9 meses (DS ± 54.8). La distribución según diagnóstico de ingreso fue semejante para ambos grupos así como la edad y porcentaje de sexo masculino. Los gérmenes más frecuentes fueron Pseudomonas aeruginosa (51%) y Klebsiella pneumoniae (14%). De los factores de riesgo evaluados, ninguno estuvo asociado a NAV. La duración de la ventilación mecánica y la estancia en UCI fueron mayores en pacientes con NAV (27.78 vs 9.22 días, p = 0.001; 34.56 vs 11.72 días, p= 0.001, respectivamente). La mortalidad también fue mayor en pacientes con NAV (51.9 vs 14.8%), OR 6.192 (2.135- 17.957), p < 0.001.

Conclusiones: No encontramos factores de riesgo asociados a NAV. La duración de la ventilación mecánica, estancia en UCI y mortalidad fueron mayores en pacientes con NAV. Se requieren estudios prospectivos con mayor número de pacientes para evaluar el impacto de ciertos factores en el desarrollo de NAV.
Hiperplasia nodular focal hepática y hepatitis granulomatosa por Brucella en una niña de 5 años
Authors: Echevarría López Nora F. , García Delgado Cesar , Flores Muro Cristina M. , Mori Torres Claudia C. , Peñaloza Rosa F. , Flores Idrovo Nube
Published: December 2023

La hiperplasia nodular focal hepática es un tumor benigno originado del tejido epitelial resultado de una respuesta hiperplásica por incremento de flujo sanguíneo secundaria a malformación vascular o daño vascular. Es raro en la infancia y usualmente se diagnostica entre los 2 y 5 años de edad.

En los niños la hiperplasia nodular focal hepática es considerada la séptima causa de tumores hepáticos entre el nacimiento y los 2 años de edad y la segunda causa entre los 5 y 20 años de edad. Se reporta el caso de hiperplasia nodular focal hepática asociado a hepatitis granulomatosa en una niña de 5 años de edad.
Reporte de caso en el Perú de lactante con hendidura labial superior, doble frenillo, hamartoma de columela y canto alveolar anterior (Sindrome Pai)
Authors: Gallardo Jugo Bertha , Abarca Barriga Hugo , Chirinos Saire Jessica
Published: December 2023

El Síndrome Pai es un raro desorden congénito, descrito por primera vez en el año 1987. Las principales características clínicas del síndrome incluyen fisura medial del labio superior, lipomas intracraneanos y pólipos cutáneos. Hasta Julio del 2008 se han reportado 16 casos a nivel mundial, 7 de los cuales en Sudamérica.
Ética y calidad de atención médica en pediatría
Authors: Peña Camarena Hugo
Published: December 2023

Para brindar atención médica de calidad en los centros de salud y hospitales del país, es necesario contar con infraestructura adecuada, implementación tecnológica suficiente y capacitación permanente del personal. Sin embargo para alcanzar esta ambiciosa meta, es imprescindible además que todo el personal de salud respete los siguientes principios de la ética médica: beneficencia, equidad, autonomía, confidencialidad, dignidad, respeto, solidaridad, honestidad, lealtad y justicia. La ética es la conciencia de la práctica médica y por lo tanto una buena práctica dentro de los preceptos de la ética, permitirá asegurar una atención médica de calidad; siendo necesario un cambio profundo en la actitud de los médicos y otros profesionales de la salud.
Ganancia de peso en prematuros con el masaje pulsátil
Authors: Anticona A. , Mayorga G. , Chirinos J. , Oliveros M.
Published: December 2023

Introducción: Hay evidencia que prematuros sometidos a masajes tienen una mejor evolución del desarrollo psicomotriz y una mayor ganancia de peso respecto a grupos de control. El estrés, el dolor, la falta de estímulo materno en esta fase de la vida temprana podrían relacionarse a problemas cognitivos y conductuales en la adolescencia y adultez. El masaje disminuye el estrés y mejora el peso de prematuros. Objetivo: Evaluar la efectividad de la aplicación de masaje pulsátil –estímulo táctil semejando al ambiente intrauterino– sobre la ganancia de peso en bebes prematuros hospitalizados en la Unidad de Cuidados Intensivos Neonatales (UCIN) del Hospital Nacional Edgardo Rebagliati Martin.

Material y métodos: Estudio prospectivo. La muestra estuvo constituida por 20 bebes prematuros de 30-34 semanas de EG. En 10 de ellos se utilizó el masaje pulsátil a través del estimulador pulsátil (Invento: Premio Medalla de Oro en Ginebra-Suiza 2000) y los otros 10 constituyen la población control. El estímulo se administró durante 7 días en la Unidad de Intermedios. Se controló peso de ingreso diariamente y peso al alta.

Resultados: Se observó una ganancia promedio de peso de 33 grs. /día en el grupo estimulado y 26 grs. /día en el grupo control durante los 7 días. Existen 7 grs./día de diferencia que constituye 28.4% más de peso en el grupo estimulado. El análisis para la diferencia de pesos de los grupos con el test “t” student (SPSS 12.0) muestra un valor estadísticamente significativo (p< 0.05).

Conclusiones y recomendaciones: Existe un beneficio en el peso de los prematuros sometidos a estimulación pulsátil, semejando el ambiente intrauterino. Sería recomendable su uso en prematuros y neonatos de alto riesgo en quienes no es posible realizar madre canguro y en quienes la falta de apego, el estrés y el dolor son frecuentes.
Riñón intratorácico sano y hernia diafragmática, hallazgos en un caso de Síndrome Jarcho-Levin
Authors: Mendoza M. , Del Pozo L. , Huamaní C.
Published: December 2023

El Síndrome Jarcho-Levin (Disostosis espondilo torácico o disostosis espondilocostal) es una condición hereditaria, cuyo fenotipo se caracteriza por múltiples malformaciones vertebrales y de costillas, con cuello, tronco y talla corta asociado a facies característica. Cuando se asocia a malformaciones renales, se llama Síndrome Casamassima. El pronóstico está directamente relacionado a las complicaciones respiratorias.

Nosotros reportamos el caso de un lactante varón de 9 meses con fenotipo de Síndrome Jarcho- Levin por las malformaciones esqueléticas caracterizadas por defectos de segmentación vertebral y alteraciones costales, además de hernia diafragmática congénita izquierda asociada a la presencia de un riñón ectópico sano ubicado en el hemitórax izquierdo. Un estudio clínico - imagenológico y descripción de su evolución.
Adaptive Materials and Aerostructures: Revolutionizing Aerospace Systems
Authors: Barrett Ron
Published: December 2023

This paper describes some of the most unique and dynamic aerospace technologies of our time. A brief historical overview traces modern Adaptive Aerostructures to their roots in subsystems of the F-14, through the bending, twisting plates of the 1980’s and the first warping-wing patents of the early 1990’s. This paper includes an overall description of the latest adaptive actuation technologies using Post-Buckled Precompressed (PBP) actuators, which enabled the first morphing-wing UAVs and world’s first post-stall maneuvering, convertible UAV which hovers like a helicopter then dashes like a missile. The paper describes the fundamental structural mechanics of these actuators and shows that they can provide up to an order of magnitude better performance than conventional adaptive actuators approaches. The paper describes future systems using such actuators in aircraft as small as 5mm to the nacelles of widebody aircraft. Coming advances are described including the latest and most capable flutter test and flight control surfaces for general aviation aircraft, business jets and commercial transports. The document concludes with a summary of the most modern optically adaptive materials and describes their performance in the first unclassified visual stealth aircraft.
Development of Data Prediction Model for the Lubrication System in a Developmental Gas Turbine Engine
Authors: Srinivasan Usha , Muthuveerappan N. , Sudhindra K.R.
Published: December 2023

A developmental aero gas turbine engine, embedded with rotating components needs to be supported with a well-designed lubrication system to address its friction, heating and cleansing requirements. To ensure and sustain the intended lube systems performance, apt and timely maintenance by continual monitoring of its performance parameters are desirable. Instrumenting the lube system and developing models to predict the feasible performance parameters are the approaches which go hand-in-hand to handle the transition from lavish ground trial instrumentation to the scanty flight trial instrumentation. This paper depicts a data prediction model which has been developed, validated and deployed for the temperature measurement in the lubrication system using the cooler temperature of an aero gas turbine engine under development. The data thus predicted as a virtual sensor, not only supplements the thermo-couple measurement during the ground trials, but also ensures its confident usage in the absence of thermocouple measurements during flight trials.
Aerofoil Design and Boundary Layer Transition Flow Studies at Subsonic Speeds for a Typical Transport Aircraft
Authors: Bhairappanavar Manjunath I. , Kulkarni Venkatesh M. , Balaraman P.
Published: December 2023

Reliable computational aerodynamic prediction of airfoil drag, maximum lift and the effect of Reynolds number continue to be a challenge to aerodynamicists, using large computer programs and memory resources even today. Design of an aerofoil for an efficient wing is presented here for the typical transport aircraft which is being developed. Flow around five digit NACA23015 aerofoil was investigated at three distinct Reynolds numbers viz, 2 x 106, 10 x 106 and 20 x 106 typical to small and medium size transport aircrafts for various angle of incidences up to stall. This paper provides insights into the geometry shape design of an aerofoil taking into consideration the effect of Reynolds number on overall efficiency i.e. the lift to drag ratio of an aerofoil. Further the paper provides some aspects of prediction and comparison of the movement of transition point for free transition flow at specific Reynolds numbers. Extensive use is made here of the open source XFOIL. With its analysis and excellent interactive inverse design capabilities for low speed single element aerofoil, the design of the aerofoil has been studied with respect to lifting characteristics, drag characteristics and pitching moment. The results are compared with those of the classical NACA 23015 aerofoil and another NASA Natural Laminar Flow (NLF) aerofoil. The comparative numerical studies using the XFOIL has shown some promising results of the modified aerofoil for use on the aircraft under design.
Unscented Kalman Filter Based Attitude Estimation Using Magnetometer and Sun Sensor Aided Mems Gyros
Authors: Jiljo K. Moncy  , Kesavabrahmaji Karuturi
Published: December 2023

The estimation of attitude of small spacecraft, limited by space and power, is achieved by using rate class MEMS gyros. Considerable drift in these sensors limits the use of inertial algorithms. Secondary sensors need to be used for the real time estimation of the drift. This paper proposes an algorithm based on Unscented Kalman Filter (UKF) which utilizes three axis magnetometer and sun sensor as secondary sensors and performs data fusion on to the gyro measurements. A 7-state UKF is used for the purpose. The paper discusses the detailed derivation of the algorithm, and the sensor models. Reference models for magnetometer and sun sensor is also included. Ability of the algorithm to cater to the effects of solar eclipse and sensor data loss for short duration are also studied.
Monopole Antenna for Experimental Flight Applications
Authors: Vani Sadadiwal  , Devender Sharma  , Vimlesh Singh  , Sarthak Singal
Published: December 2023

A monopole dual band antenna for experimental flight applications on a small scale Unmanned Aerial Vehicle available in the Aero modeling lab of Department of Aeronautical Engineering at Manav Rachna International Institute of Research and Studies is presented in this paper. Radiating patch of proposed antenna consists of concentric circle at resonance frequency of 1.35 GHz and 5.25 GHz. The minimum reflection constant at 1.5 GHz is -20 dB and 5.2 GHz is -36 dB. The bandwidth of 300 MHz and 830 MHz achieved during the design process is considered adequate for efficient and effective utilization of the designed antenna. Radiation pattern of proposed antenna show Omnidirectional pattern. Designed antenna provides solutions for L and C band aviation application for early reported geometry. Various parameters like return loss, gain, radiation pattern surface current and Voltage Standing Wave Ratio (VSWR) have been studied and analyzed using the application software CST Microwave Studio. The experimental antenna designed for experimental flight evaluation can also be used as Global System for Mobile Applications (GSM), Worldwide Interoperability for Microwave Access (WiMAX), Wireless Local Area Network (WLAN), Walkie-Talkie and Air Traffic Control (ATC) antenna. In the overall perspective, the proposed antenna can also be utilized for ground communication and other airport facilities in addition to the experimental role envisaged.
Design, Analysis and Testing of Mechanism to Reduce The Impact on Drones in Failure
Authors: Shashankh S. , Amol  , Adarsh M. , Krishna Murthy N. , Hareesha N. G.
Published: December 2023

This work aims at proving the concept of an autorotation-based crash prevention system for drones. The work focuses on quadcopters, whereas the concept can be used for all multi-copters in general with slight modification in design. The system works on the principle of autorotation which is a commonly used method in helicopters for unpowered landing. The autorotation system causes a gyroscopic effect preventing the quadcopter from changing its orientation during fall and also provides drag that helps in reducing the fall velocity. This technique reduces the energy that needs to be absorbed by the quadcopters structure during impact by converting a part of the kinetic energy of fall to the rotational kinetic energy and also creating a profile normal to the local airflow to produce drag. To prove this concept, the terminal velocity of the fall is obtained by mathematical modelling and this is compared with practical results in order to verify the theoretical results. Experimentally, a substantial reduction in velocity was found and this proves that the autorotation mechanism indeed reduces impact during failure in drones.
Nonlinear Response Behaviour of Passive Isolators Subjected To Low Values of Base Sine Excitation
Authors: Renji K.
Published: December 2023

Passive isolators are widely employed in reducing the vibrations experienced by an equipment. Isolator with linear response is preferred as the isolation is independent of amplitude of excitation. However, an example of such a linear isolator exhibited nonlinear behavior during testing, where the resonance frequency was getting significantly reduced as the amplitude of excitation is increased. This behavior is investigated in this work. It is shown that the isolators exhibit linear response when subjected to rated deformations, but can develop nonlinear type response behavior when the deformations are low and excited through the base. A cubic spring-mass model with the applicable nonlinear parameters is able to represent this behavior. The measured responses and the theoretically estimated responses agree with these characteristics, but needs improvement in the prediction, especially at intermediate levels of excitations. The nonlinearity seen in the force-deformation relation of such isolator appears to be small and the frequency of the free oscillation does not vary much from the linear natural frequency. However, it is shown in this work that a predominant nonlinear response behaviour is developed in the isolators when they are subjected to low levels of base excitation. This nonlinear behaviour needs to be considered when employing such passive isolators in applications where base excitations are present and the deformations are very low relative to the rated specifications.
CG Based Design Optimization of Aircraft Drop Tanks
Authors: Krishna Prasad V. , Sooraj Kumar K.
Published: December 2023

A new method is introduced to locate the partitions in external fuel tanks, a.k.a. drop tanks of combat aircraft. Using operational requirements to simplify the fuel transfer sequence, an optimization algorithm is developed to reduce the variation in aircraft Centre of Gravity (CG). A conservative limit on the CG effect of fuel slosh is introduced. This method results in locating the tank partitions such that dynamic effects on CG-variation are minimized. The method can be generalized and used in the design of any external drop tank. This ab-initio method is developed based on the experience gained in the development of a legacy fighter aircraft fuel system.
CFD Studies of Aircraft in Ground Effect for Saras MK II
Authors: Shikhar Jaiswal A. , Madhu Babu K. , Puttam Jyothi Kumar , Arshad Shameem C. , Sajjan Sharanappa V. , Venkatesh T. N.
Published: December 2023

Aerodynamic performance of an aircraft is affected when it is flying close to the ground, for example during take-off or landing. In order to estimate this effect, CFD simulations have been carried out over the SARAS Mk II aircraft configuration using an open source CFD solver with Spalart Allmaras (SA) turbulence model. The simulations were done for aircraft at different heights above the ground with flaps deployed and at different angles of attack with propeller power on. The take-off flap deflections of 15° and 20° and landing flap deflections of 30° and 35° were considered for the simulations. Power effects were modelled by using actuator disc model available in SU2. From the simulations, it is observed that, for all flap configurations and at all angles of attack studied, flying close to ground increases the lift of the aircraft, reduces drag and pitching moment. The factors of increase/reduction are used by the design group for better estimation of aircraft performance.
Calibration of Multi Hole Pressure Probes for Three Dimensional Flow Measurements in Subsonic Flow*
Authors: Sitaram N. , Yadav Pillala Vital Kumar , Prasad B.V.S.S.S , Purushothama B.
Published: December 2023

The calibration of two multi hole pressure probes with four and five pressure holes are presented at three Mach numbers, viz. M=0.3, 0.4 and 0.5. The calibration was carried out in a subsonic calibration tunnel in yaw angle and pitch angle range of ± 30° at 5° interval. Calibration curves are presented and compared at the three Mach numbers. Calibration data at one Mach number are used as calibration data and calibration data at other Mach numbers are used as measured data to find the flow parameters namely, total pressure and static pressure and flow yaw angle and pitch angle using a lookup table method at these Mach numbers. The interpolation errors are small when the yaw angle and pitch angle range is from -20° to 20° for the four hole probe and from -15° to 15° for the five hole probe. Mach number effects on the flow measurements can be incorporated using the iterative method presented. This method is used to obtain flow parameters in the wake of a steam turbine rotor tip cascade blade. The differences in the obtained values using calibration coefficients at three Mach numbers are found to be negligible.
ПРОБЛЕМЫ ПРАВОПРИМЕНЕНИЯ ПОНЯТИЯ «ГАЗ» В НОРМАТИВНЫХ ДОКУМЕНТАХ
Authors: Khachatryan Hayk
Published: December 2023

Gas is extremely important in the modern economy, therefore, the specification of the concept of «gas» is of particular importance. In particular, it is most important when drafting international treaties and agreements. Clarifying the concept of «gas» and considering its use in various documents is an urgent task. The analysis carried out in this article shows that almost all activities related to natural gas in the Republic of Armenia are regulated by the laws of the country, and this does not give grounds for comments or discrepancies.
CREATING BOUNDARIES TO MAINTAINING A HEALTHY WORK-LIFE BALANCE
Authors: Dr. K. MAJINI JES BELLA
Published: December 2023

This study explores the significance of creating boundaries as a fundamental strategy for cultivating and sustaining a healthy work-life balance in the contemporary professional landscape. As the lines between work and personal life become increasingly blurred, individuals are confronted with the need to establish clear boundaries to safeguard their well-being. It highlight into various dimensions of boundary-setting, encompassing delineation of working hours, strategies for disengaging from work-related communication during personal time and the establishment of limits on workload expectations. The objective is to understand how these boundaries contribute to individual well-being, mitigate stress and enhance the job satisfaction. Through a comprehensive examination of practices that facilitate boundary-setting, this study aims to provide valuable insights for individuals and organizations seeking to foster environments that promote a sustainable and fulfilling work-life balance.
CLINICAL COURSE, TREATMENT AND PROGNOSIS OF CEREBROVASCULAR DISORDERS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Salamova S.M.
Published: December 2023

Type 2 diabetes mellitus (DM2) significantly increases the risk of stroke, dementia, and other cognitive and mental disorders. Atherosclerotic type of cardiovascular disorders (CVD) is the main cause of death in patients with DM2. Aim. In this review, we aimed to outline risk factors, clinical characteristics and outcomes of stroke in patients with DM2. The obtained information can be used to improve prevention, early diagnosis, and treatment of cerebral vascular disorders in DM2. Materials and Methods. We conducted a systematic review of prognostic and risk factors of cerebral vascular disorders in DM2. Our search included 50 articles from PUBMED published in the last few years. We compared statistical data from Azerbaijan with those from other countries. Results. Hyperglycemia, obesity, insulin resistance and arterial hypertension (AH) are all risk factors of brain microvascular dysfunctions in patients with diabetes mellitus. Furthermore, obesity, AH, dyslipidemias, smoking and genetic predisposition to CVD, chronic kidney disorders, and albuminuria are all risk factors of cardiovascular disorders in DM2. The possible outcomes can be a stroke, cognitive dysfunction, and depressive disorders. For Azerbaijan, main risk factors is an atherosclerotic type of CVD. Conclusion. Due to the high socio-economic burden of disease there is an urgent need in new approaches aimed at prevention, early diagnosis and treatment of cerebral vascular disorders in patients with DM2 in Azerbaijan.
NON­SPECIFIC BACK PAIN AMONG EMERGENCY MILITARY PERSONNEL: APPROACHES TO THERAPY
Authors: Mirjuraev E.M. , Akilov D.Kh. , Djabbarov A.M.
Published: December 2023

The structure of primary dorsalgia was studied in 101 emergency military personnel. The patients had pain in the lumbar region. The complex treatment of dorsalgia, which included non-steroidal anti-inflammatory drugs (NSAIDs), muscle relaxants in combination with diadynamic neurostimulation, massage, therapeutic exercises and an educational program ("school" for patients with back pain), revealed its effectiveness in emergency military personnel.
Understanding the Utilization of Skills by Returnee Workers in Rupandehi District
Authors:   Campus Chief Parroha Multiple Campus, Rupandehi, Nepal, Kharal hemchandra , Rana Ashok ,   Assistant Lecturer Parroha Multiple Camps, Rupandehi, Nepal
Published: December 2023

This qualitative research study aims to understand how returnee workers' skills are being converted into sustainable earnings by the application of the gained knowledge in different economic activities. The study uses a field survey of returnee workers in Rupandehi District, Nepal, and includes detailed discussions with key stakeholders in the study area. Returnee workers have gained language skills, technical skills, and management skills. These skills are being utilized in different economic activities, including agriculture, tourism, and small businesses. However, returnee workers face challenges related to social reintegration, including cultural differences and a lack of social support. The study recommends that the government should provide support for returnee workers to help them reintegrate into society and utilize their skills effectively. The study's findings are important because they highlight the need for effective utilization of the skills and knowledge gained by returnee workers to promote sustainable economic growth in Nepal. The study also emphasizes the importance of social support for returnee workers to facilitate their reintegration into society. The study's recommendations can help the government and other stakeholders to develop policies and programs that support returnee workers and promote sustainable economic growth in Nepal. Keywords: Returnee workers, Skill utilization, Sustainable earnings, Social reintegration, Economic activities, Nepalese society
PENGARUH KOMPOSISI BAHAN BAKU TERHADAP BIAYA BAHAN BAKU, HARGA POKOK PRODUKSI, DAN PRODUKTIVITAS MASSA BODI BL PADA UPT PSTKP BALI-BPPT TAHUN 2014
Authors: Normal I Nyoman , Suputra Gumi Wiryawan
Published: December 2023

The aims of this research that relate raw material composition intoproduction process of BL (BL1X, BL2, BL1, BL3) stoneware were: (1) To know theinfluence of raw material composition to raw material cost loading stoneware BL;(2) To know the influence of raw material composition to cost of good manufacturedcalculation; and (3) To know the influence of raw material composition toproductivity.The research results shew that: (1)The increasing of raw material composition kalblend clay on production process of BL stoneware could decrease raw material cost of BL stoneware. For that, if the UPT PSTKP Bali want to decrease raw materialcost of BL stoneware, so it could act by increase composition of kalblend clay in thatraw material mixing; (2) The increasing of raw material composition kalblend clayon production process of BL stoneware could decrease cost of goods manufacturedBL stoneware. For that, if the UPT PSTKP Bali want to decrease cost of goodsmanufactured BL stoneware, so it could act by increase composition of kalblend clayin that raw material mixing; and (3) The increasing of raw material compositionkalblend clay on production process of BL stoneware could decrease productivityof BL stoneware. For that, if the UPT PSTKP Bali want to decrease cost of goodsmanufactured BL stoneware, so it could act by increase composition of kalblend clayin that raw material mixing
Study of Meaning and Function in Koa Baradaik Game in Nagari Duo Koto, West Sumatra
Authors: Durin Hasan Basri
Published: December 2023

Koa game  is one of the activities carried out by Minang men that still exists today. Generally,  Koa games  are played by four people in pairs (Mandan) in a sitting position and facing each other. In the Koa game, there is a game concept called Baradaik.  Koa Baradaik is a form of game based on normative ethics applied in each game. This paper aims to discuss the meaning in the  game Koa Baradaik and its correlation to social life. The method used in this paper is a qualitative research method of analysis with an ethnographic approach. The data type consists of primary data and secondary data with data sources consisting of field observations, interviews, and documentation. Data analysis was carried out using normative ethical theory. The results of the study stated  that the  Koa Baradaik game  is a game that adopts the Minangkabau philosophy which aims to bind and prevent deviant behavior by each individual. In addition, Koa baradaik gives birth to functions consisting of  (1). Means of thought (2). Koa baradaik becomes a cultural identity in the form of games that contain normative ethics.(3). Koa Baradaik as a means of forming social interaction.
The Application For A Polygamy Permit Is Reviewed From An Islamic Legal Perspective (Analysis of PA.Depok Decision No. 3051/Pdt.G/2020/PA.Dpk)
Authors: Ameliah Elvita , Songgirin Amin , Ahmed Abdussalam Ali Ahmed
Published: December 2023

Polygamy or having more than one wife is permissible under the provisions of Islamic law and positive law. Even though the large number of polygamy in our society has never been investigated in research what the real motives and causes are, in reality most polygamy is carried out by our society not in accordance with all the provisions, so that the polygamy that is carried out is very far from the wisdom and secrets contained therein. The permissibility of practicing polygamy according to Islam in many cases is often implemented and implemented. This causes many things to happen at will, without paying attention to and heeding the conditions that must be met. The problems in this thesis are how the judge considers in the decision on the case for a polygamy permit application No.3051/Pdt. G/2020/PA.D pk and what are the aspects of justice for polygamy applicants. This research method uses normative juridical research or a normative legal approach and is commonly called library research. The data collection technique in this research is library research which originates from laws and regulations, books, publications and research results. Based on the research results it is known that: 1). In determining the decision on the principle of proving the polygamy licensing case, the judge considered that the respondent did not mind polygamy by her husband, referring to Law No. 1 of 1974 to serve as a guideline in resolving polygamy problems. However, the judge did not grant the petitioner's request. 2). The concept of fairness in polygamy, according to the judge, goes back to Islamic teachings, namely justice that is meant is justice that is material in nature that can be controlled by the husband and becomes his ability, such as good treatment, sharing of time in spending the night, and giving a living. As for those related to the heart, then she may not be able to do it, because it is beyond the husband's control or beyond his ability, such as feelings of love and inclinations of the heart. So in this case the husband is not required to make it happen because it is beyond human power which is impossible to fulfill. Then the judge saw the fairness of the decision by looking at the statement made by the husband to be able to act fairly in guaranteeing the needs of his wives and children.
The Influence of Profitability and Leverage on Tax Avoidance in Manufacturing Companies Listed on the Indonesian Stock Exchange 2018 - 2020
Authors: Nurrobani Mohamad Rizqi
Published: December 2023

Tax is one of the largest revenues in the APBN, but when compared to the realization of the tax revenue target, it is still not appropriate. In this thesis the author indicates that this happened because there was resistance made by the taxpayer in the form of tax avoidance. This study aims to determine the magnitude of the influence of Profitability, and Leverage on Tax Avoidance in manufacturing companies listed on the Indonesia Stock Exchange in 2018 - 2020. The data used in this thesis is secondary data, namely financial statements obtained from the official website of the Indonesia Stock Exchange ( www.idx.com). Sampling by purposive sampling was obtained as many as 10 companies with a research time of 2018 - 2020. The analysis method used was the regression test method and used SPSS version 24 for data processing. The results of this study indicate that profitability partially has a significant positive effect on tax avoidance, partially leverage has a significant positive effect on tax avoidance. Profitability, and Leverage, simultaneously have an effect on tax avoidance.
Etablering af fælles fodslag
Authors: Steenberg Josephine Lyngh , Hørmann Thomsen Trine , Lynning Marie , Olsgaard Bergien Sofie , Pringler Holm Rolf , Skovgaard Lasse
Published: December 2023

Brug af Patientrapporterede Oplysninger (PRO) i mødet mellem patient og sundhedsprofessionel kan styrke patientinddragelsen og højne behandlingskvaliteten. Formålet med dette studie er at undersøge, hvordan PRO bliver relevant og meningsfuldt at anvende for både personer med multipel sclerose (MS) og sundhedsprofessionelle.

Undersøgelsen bestod af 1) et systematisk litteraturstudie, hvor eksisterende PRO-spørgeskemaer indenfor MS-området, og hvorvidt der har været inddraget patienter i udviklingen af dem, blev kortlagt2) en interviewundersøgelse, hvor personer med MS’ perspektiv på PRO blev undersøgt, 3) en workshop hvor sundhedsprofessionelles perspektiv på PRO blev undersøgt.

Der er et øget behov for at inddrage personer med MS i udviklingen af PRO, hvis PRO skal være relevant for personer med MS samt fremme personcentrering i MS-behandlingen. For at PRO-spørgeskemaer bliver meningsfulde for både personer med MS og sundhedsprofessionelle at anvende, skal PRO kunne tilpasses den enkelte patient, da sygdomsforløbet og symptomprofilen for personer med MS kan variere meget. Imidlertid bør det overvejes om alle patienter har gavn af PRO. For at favne, hvad der for personer med MS er relevant at drøfte med en sundhedsprofessionel, bør PRO-spørgeskemaer omfatte neurologiske symptomer, kognitive funktionsnedsættelser, mental sundhed og velvære, egenomsorg og sociale udfordringer relateret til MS. Dog bør dette afstemmes ift. den sundhedsprofessionelles kompetencer, både for at den sundhedsprofessionelle oplever at kunne give evidente råd om symptomer og behandling, men også for at patienten modtager den bedst mulige behandling og vejledning. Desuden må PRO ikke være tidskrævende, hverken for de sundhedsprofessionelle at anvende eller for patienterne at udfylde. Imidlertid kan det diskuteres, hvorvidt det danske sundhedsvæsen rustet og organiseret til at inkorporerer et tiltag som PRO, som reflekterer både patienter og sundhedsprofessionelles ønsker og behov.
KAVRAMSAL SANAT PARADİGMASINDA ENSTRÜMAN YAPIMI VE POSTMODERN DUYSAL TASARIM ALANLARINA BİR YANSIMASI OLARAK SOUND SCULPTURE KAVRAMININ DÖNÜŞTÜRÜCÜ İZDÜŞÜMLERİ
Authors: TURAN Özgür , MARAL Hakkı Alper
Published: December 2023

Yapıt kurma edimi üzerinden sanat, zanaat ve tasarım gibi nosyonları türeten bireyler, bu kavramları merkezlerine alan farklı disiplinlerde olduğu gibi duysal bağlamın tasarı olanaklarını da keşfetmiş ve çeşitli uygulamalar üzerinden hayata dair nice derinlikli alımlama biçimleri deneyimlemişlerdir. Bu süreç, müzik/ses üretiminden bunları gerçekleştirecekleri araçlara; müziği icra edecekleri mekânların mimarisinden, bu performansları kayıt altına alacakları teknolojilere kadar izdüşümleriyle, özellikle 19. Yüzyılın son çeyreğinden itibaren, geniş bir alana yayılan duysal tasarım çalışmalarının plastik ve görsel sanatlarla sınırlarını muğlaklaştırmış, öğelerini geçişkenleştirmiştir. Fütüristlerin sıkça örneklenen; hız, zaman ve sesle ilişkilendirdikleri üretimleri, özellikle Russolo’nun Intonarumori’leriyle, sanatsal ses/enstrüman çalışmalarının erkence örneklerinden birini verdiği, The Art of Noise manifestosuyla pekiştirilmiş ve belgeleştirilmiştir. Keza, Duchamp’ın 20. Yüzyılın başında Sculpture Musicale, With Hidden Noise gibi Dadacı çalışmaları Sound Object, Sound Sculpture, Sound Art gibi alanların tanımlanması bakımından öncü niteliktedir. Aynı yüzyılın ortalarındaysa sosyoekonomik gelişmelere koşut, yeni teknolojiler ve kavramsal arka plan üzerinden sanatsal ses çalışmalarının tanımı ve sınırları daha da genişlemiştir. II. Dünya Savaşı sonrasında birçok alanda olduğu gibi müzik ve ses pratiklerinde de önemli dönüşümler gerçekleşmiş; bu alanların kavramsal boyutları tartışmaya açılmıştır. Özellikle 1960’lardan sonra Postmodernizmin de etkisiyle sound kavramı, yeni üretim ve malzeme teknolojileriyle dönüşümler deneyimleyen enstrüman tasarım alanlarıyla yepyeni boyutlar kazanmış, peşi sıra yeni önermelerine kavuşmuştur. Nitel araştırma yöntemleri kullanılarak hazırlanan bu derleme makalede; deneysellikle başlayan enstrüman tasarım alanlarıyla içli dışlı ve birbirlerine koşut ilerleyen, zamanla duysal tasarım alanının müstakil bir üretim alanına evirilen, Sound Sculpture türünün gelişimi; 20. ve 21. Yüzyıl çağdaş sanat akımları içerisindeki konumu, kavramsal arka planı, başat önermeleri üzerinden incelenmektedir. Bu çalışmada aynı zamanda gelenekselleşen enstrüman yapım pratiklerine koşut, deneysel ve kavramsal bir enstrüman yapım alanı olan Sound Sculpture türü alternatif bir öneri olarak sunulmaktadır.
Weak pulse signal detection method based on improved strongly coupled oscillators
Authors: Li Yuan-Fang , Jiang Yuan , Zhao Lei ,   School of Electronic and Communication Engineering, Sun Yat Sen University, Shenzhen 518107, China
Published: December 2023

A strongly coupled oscillator can be used to detect weak pulse signals and recover waveforms, but its detection frequency of weak pulse signal is limited by the system’s built-in frequency. With a fixed built-in frequency, the system can only effectively detect and recover pulse signals in a certain frequency range, and waveform distortion occurs when pulse signals of higher frequencies are detected. In this work, the relationship between the built-in frequency of the coupled oscillator and the frequency detection range of weak pulse signal is analyzed, and two kinds of improved strongly coupled oscillator structures are proposed to extend the frequency detection range of weak pulse signals. By introducing the nonlinear restoring force coupling term, the nonlinear restoring force strongly coupled oscillator can effectively retain the high-frequency component of the signal, and can also better retain the signal characteristics when the pulse signal is input at a higher frequency. By introducing the Van der Pol-Duffing oscillator, the two-oscillator strong coupling system strengthens the stability of the internal structure of the system, and also achieves the effect of expanding the frequency detection range of the pulse signal. In addition, based on the variable iteration step size and frequency correlation of chaos detection, a method of detecting unknown frequency pulse signals is proposed. Instead of changing the built-in frequency of the system for frequency scanning, the method of changing the iteration step size is used. And using the frequency correlation of chaos detection, the correlation coefficient of the received signal and the recovered signal is compared with the correlation coefficient of the pure noise input case, then the pulse signals can be effectively detected based on the apparent difference between the two correlation coefficients. It is verified by simulation experiments that the proposed method can effectively detect the pulse signal of unknown frequency, and the proposed improved strong coupling oscillator has a greater performance improvement than that of the strong coupling oscillator.
A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis
Authors: Jyotsna  , Sarkar Binayak , Yadav Mohit , Deka Alvina , Markandey Manasvini , Sanyal Priyadarshini , Nagarajan Perumal , Gaikward Nilesh , Ahuja Vineet , Mohanty Debasisa , Basak Soumen , Gokhale Rajesh S
Published: December 2023

Hepatic factors secreted by the liver promote homeostasis and are pivotal for maintaining the liver-gut axis. Bile acid metabolism is one such example wherein, bile acid synthesis occurs in the liver and its biotransformation happens in the intestine. Dysfunctional interactions between the liver and the intestine stimulate varied pathological outcomes through its bidirectional portal communication. Indeed, aberrant bile acid metabolism has been reported in inflammatory bowel disease (IBD). However, the molecular mechanisms underlying these crosstalks that perpetuate intestinal permeability and inflammation remain obscure. Here, we identify a novel hepatic gene program regulated by Rela and Stat3 that accentuates the inflammation in an acute experimental colitis model. Hepatocyte-specific ablation of Rela and Stat3 reduces the levels of primary bile acids in both the liver and the gut and shows a restricted colitogenic phenotype. On supplementation of chenodeoxycholic acid (CDCA), knock-out mice exhibit enhanced colitis-induced alterations. This study provides persuasive evidence for the development of multi-organ strategies for treating IBD and identifies a hepatocyte-specific Rela-Stat3 network as a promising therapeutic target.
Beyond top-k: knowledge reasoning for multi-answer temporal questions based on revalidation framework
Authors: Yao Junping , Yuan Cong , Li Xiaojun , Wang Yijing , Su Yi
Published: December 2023

Answer sorting and filtering are two closely related steps for determining the answer to a question. Answer sorting is designed to produce an ordered list of scores based on Top-k and contextual criteria. Answer filtering optimizes the selection according to other criteria, such as the range of time constraints the user expects. However, the unclear number of answers and time constraints, as well as the high score of false positive results, indicate that the traditional sorting and selection methods cannot guarantee the quality of answers to multi-answer questions. Therefore, this study proposes MATQA, a component based on multi-answer temporal question reasoning, using a re-validation framework to convert the Top-k answer list output by the QA system into a clear number of answer combinations, and a new multi-answer based evaluation index is proposed for this output form. First, the highly correlated subgraph is selected by calculating the scores of the boot node and the related fact node. Second, the subgraph attention inference module is introduced to determine the initial answer with the highest probability. Finally, the alternative answers are clustered at the semantic level and the time constraint level. Meanwhile, the candidate answers with similar types and high scores but do not satisfy the semantic constraints or the time constraints are eliminated to ensure the number and accuracy of final answers. Experiments on the multi-answer TimeQuestions dataset demonstrate the effectiveness of the answer combinations output by MATQA.