bluuebunny/crossref_metadata_2025 huggingface dataset:
Elastic Magnetic Membrane for Improved Mixing in Microwells
Authors: Chong Zhuang Zhi , Sim Wee Jun , Yeo Ze Ting , Li King Ho , Ng Sum Huan , Xia Huanming , Wong Teck Neng , Ngiap Hiang Loh  , Shu Beng Tor  , Say Hwa Tan  , Nam-Trung Nguyen
Published: June 2022

We demonstrate a simple method to fabricate elastic magnetic membrane which could be
used to enhance mixing in microwells of a microtitre plate. The magnetic membrane was fabricated
using an off-the-shelf flexible magnetic sheet and the elastomer polydimethylsiloxane (PDMS). In order to demonstrate the concept, the membrane was integrated in a single microwell to act as an actuator for improved mixing. A customized electromagnet was used to allow contactless and robust actuation. The membrane can achieve a unidirectional deflection of about 120 µm when a 3 A direct current (DC) is applied. Periodic deflection is achieved by applying a square wave alternating current (AC) of 100 Hz and ±3 A. In the dynamic case, the membrane follows the square
wave with the same frequency and provides a peak-to-peak deflection of about 115 µm. The observed oscillation was able
to mix the fluorescent dye and an aqueous solution within 18 seconds. The proposed method has the potential to be implemented in microtiter plate arrays to improve mixing.
Chitosan-grafted Microspherical Loaded In-situ Gels for Enhanced
Transdermal Delivery of Roxithromycin: In-vitro/Ex-vivo Assessment
Authors: Singh Pankaj , Dubey Amit Kumar , Singh Rahul Kumar
Published: June 2022

Background:

Atleast once in life everyone experience different kinds of dermal diseases
and the conventional dosage forms having a high rate of side effects. The discussed method is a better
and alternative approach in case of patients’ compliance and sustained drug release.

Objective:

The objectives of this study are to prepare solid dispersion for enhancement of solubility of
roxithromycin, encapsulation of solid dispersion into microspheres, decreased dose frequency, sustained
release and incorporation of microspheres in in situ gel for easy utilization and adherence over
the skin in microbial infection.

Methods:

Solid dispersion of roxithromycin and HPMC at a ratio of 1:1 was prepared by the melting
method, and solubility was measured by in vitro dissolution rate. On the basis of 3² factorial design, 9
different formulations were evaluated by % drug release, particle size, and % entrapment efficiency.
Lastly, in situ gel was prepared by a cold method, which was evaluated through gelling time and temperature;
in vitro gelation method.

Results:

The solid dispersion was found to have a 1.3 times higher solubility than pure roxithromycin
as proven by in vitro drug release. Whereas, microsphere MF-9 was selected as the best formulation
via drug release (87.81%), entrapment efficiency (91.223%), % yield (86.681), and particle size
(110μm). In-situ gel MIG-5 was selected as the best formulation on the basis of drug content
(89.326±0.564), viscosity (9551.666±6.233), and gelling time (25.333±2.054).

Conclusion:

Solid dispersion was prepared successfully with higher solubility than the pure drug. Microspheres
have shown sustained drug release and in situ gels have a good adhesive property and
MIG-5 further enhances the sustained drug release behaviour.
Hybrid Electricity Consumption Prediction Based on Spatiotemporal
Correlation
Authors: Wang Shenzheng , Wang Yi , Cheng Sijin , Zhang Xiao , Li Xinyi , Li Tengchang
Published: June 2022

Background:

Electricity consumption forecast is an important basis for the power system to achieve regional electricity balance and electricity spot market transactions.

Objective:

In view of the fact that many electricity consumption prediction models do not make good use of the correlation of data in time dimension and space dimension, this paper proposes a day-ahead forecasting model based on spatiotemporal correction, which further improves the forecasting accuracy of electricity demand.

Methods:

Firstly, the long short-term memory (LSTM) model is used to construct the forecasting model. Secondly, from the perspectives of time correlation and space correlation, meanwhile considering calendar factors and meteorological factors, the K-Nearest Neighbors (KNN) model is taken to construct correction models, which can correct the forecasting results of LSTM.

Results:

According to the analysis of power consumption data of 9 areas in New England, the mean absolute percentage error (MAPE), mean absolute error (MAE), and root mean square error (RMSE) of time dimension correction model are reduced by 0.35%, 5.87% and 5.06%, and the 3 evaluation metrics in space dimension are decreased by 0.52%, 6.82% and 7.06% on average.

Conclusion:

The results prove that the models proposed in this paper are effective.
Comparative Study of Machine Learning Algorithms towards Predictive
Analytics
Authors: Petchiappan Maheswari , Aravindhen Jaya
Published: June 2022

Background:

The trend of the stock market prediction has always been challenging and confusing for investors There is tremendous growth in stock market prediction with the advancement of technology, machine learning, data science, and big data. The media and entertainment sector is one of the diverse sectors in the stock market. In the Indian stock market, Sensex and Nifty are the two indexes. The 2019 pandemic forced the movie theatres to shut down. As a result, distributors and film directors were not able to release their movies in theatres, and production also was stopped. Consequently, during the lockdown, people spent more time at home watching media. Resulting in a higher degree of media consumption.

Objectives:

The objective of the research is to predict the performance of the media and entertainment company's stock prices using machine-learning techniques. Investors will be benefited by maximizing the profit and minimizing the loss.

Methods:

The proposed stock prediction system is used to predict the stock values and find the accuracy of linear
regression and logistic regression in machine learning algorithms for data science.

Results:

The experiments are conducted for the media and entertainment stock price data using Machine-learning algorithms. Media stock prices are considered as the input dataset. The model has been developed using the daily frequency of stock prices with different attributes.

Conclusion:

Thus, the media and entertainment stocks are predicted using linear regression and logistic regression. Using the above techniques, stock prices are predicted accurately to maximize profits and minimize the loss for the investors.
Nanoformulations Enabled Possible Solutions for the Management of
Psoriasis
Authors: Srivastava Nimisha , Gupta Rishabh
Published: June 2022

Psoriasis is a chronic inflammatory disease with clinical skin manifestations that affect
adults and children. It can significantly negatively impact the physical, emotional, and psychosocial
well-being of affected patients. It has a strong genetic component, but environmental factors such as
infections can play an important role in the presentation of the disease. Patients suffering from a severe
phase of this disease may have greater chances of other diseases like cardiovascular diseases, nonmelanoma,
and lymphoma. The present review majorly focuses on the hallmarks of different types of
psoriasis, the evaluation of biomarkers to establish the severity and therapeutic response, and novel
targeted therapies for managing psoriasis. Potential herbal extracts and bioactive for treating psoriasis
are also highlighted here. A summary of pertinent, peer-reviewed English literature from databases
like EBM, EMBASE and MEDLINE from 2010 to 2021 is used.
Cambios en la diversidad de aves ante la perturbación de hábitats del sur de Quintana Roo, México
Authors: Farías-Rivero Nancy A. , Ramírez-Barajas Pablo Jesús , Cedeño-Vázquez J. Rogelio , Sánchez-Sánchez Joan , Asselin-Nguyen Antoine , Macario- Mendoza Pedro Antonio , Tuz-Novelo Margarito
Published: June 2022

Actualmente, los ecosistemas enfrentan una gran pérdida de biodiversidad debido a perturbaciones antrópicas, lo cual que tiene efectos negativos en los procesos ecológicos. Para conocer el estado de conservación de un ambiente se pueden determinar especies indicadoras, que desempeñan un rol importante en distintos procesos ecológicos y son sensibles a los disturbios. El objetivo de este estudio fue determinar la diversidad y composición de aves en respuesta a diferentes perturbaciones del hábitat en el ejido Laguna Om, Quintana Roo, México, mediante conteo por puntos de agosto a septiembre de 2017. Se seleccionaron hábitats con diferente estado de conservación denominados: Selva, Laguna, Carretera, Potrero y Helechal. La mayor riqueza de especies se registró en los hábitats de Laguna y Carretera. Los patrones de abundancia de especies tolerantes a la perturbación fueron mayores en las áreas perturbadas. Encontramos mayor similitud en la composición de los gremios tróficos de las especies entre Laguna y Selva, y entre Helechal y Carretera, mientras que la composición en Potrero no mostró similitudes respecto a los otros hábitats. La diversidad y la composición de las especies de aves dependen de la complejidad estructural a nivel de hábitat, más que el tipo de perturbación que se asocia localmente.
La ciudad de los habitantes y sus deseos
Authors: García Moreno Beatriz
Published: June 2022

Se dice que en las transformaciones de la ciudad no solo intervienen las instituciones y sus organismos de planeación, sino las prácticas de sus habitantes, considerados estos como seres hablantes provistos de deseo y de goce. Mediante estas prácticas, el espacio, al ser apropiado, se convierte en lugar; la ciudad construida se vuelve maleable; sus formas, al parecer predefinidas, se ofrecen a usos contingentes y múltiples; y que las diferentes temporalidades que la constituyen, se actualizan en un presente. Los habitantes-sujetos, para sus prácticas, requieren de un campo simbólico que provea de cauces para que su deseo fluya.
Los espacios rururbanos en Colombia: algunos elementos para su discusión
Authors: Macuacé Otero Ronald Alejandro
Published: June 2022

El presente artículo tiene como objetivo reflexionar sobre los procesos rururbanos en Colombia. La captura de información, asociada a este fenómeno, fue el principal insumo para la construcción del trabajo. De la misma forma, la discusión teórica y los antecedentes muestran un cúmulo descriptivo de base, donde se cruzan distintos elementos sobre la producción del territorio en América Latina. Al respecto, es importante señalar que, los procesos rururbanos son una realidad en las ciudades colombianas, independientemente del tamaño de las mismas, lo cual requiere de un abordaje específico. Finalmente, es necesario que se tomen medidas de política, que permitan una mejor articulación entre lo urbano y lo rural.
El Rio fantasma
Authors: Arias Duque Sebastián
Published: June 2022

El río Consotá es un afluente hídrico importante, para la ciudad de Pereira y para toda la región risaraldense. Es uno de los ejes ambientales principales, que atraviesan de oriente a occidente la ciudad. La cuenca que enmarca el rio Consotá, presenta unas características, tanto físicas como ambientales, que demuestran mucho potencial a la hora de resignificar y darle un valor importante al rio y a su entorno; resaltando, también, lo que corresponde a un ámbito comunitario y a un tejido social que han sufrido diferentes situaciones, que han vulnerado su núcleo a través de los años. Como objetivo, el proyecto busca recuperar toda la cuenca del rio Consotá, con una visión de ciudad inclusiva, que integre a la población con el eje ambiental, con su historia, con su cultura ancestral y con su biodiversidad. Se destacan aspectos claves en la historia, y cómo ha influido el Consotá en el desarrollo de la ciudad, y su significado.
Implementing a Health Utility Assessment Platform to Acquire Health Utilities in a Hemodialysis Outpatient Setting: Feasibility Study
Authors: Adejare Adeboye A , Duncan Heather J , Motz R Geoffrey , Shah Silvi , Thakar Charuhas V , Eckman Mark H
Published: June 2022

Background

Patients with end-stage kidney disease (ESKD) wait roughly 4 years for a kidney transplant. A potential way to reduce wait times is using hepatitis C virus (HCV)–viremic kidneys.

Objective

As preparation for developing a shared decision-making tool to assist patients with ESKD with the decision to accept an HCV-viremic kidney transplant, our initial goal was to assess the feasibility of using The Gambler II, a health utility assessment tool, in an ambulatory dialysis clinic setting. Our secondary goals were to collect health utilities for patients with ESKD and to explore whether the use of race-matched versus race-mismatched exemplars impacted the knowledge gained during the assessment process.

Methods

We used The Gambler II to elicit utilities for the following ESKD-related health states: hemodialysis, kidney transplant with HCV-unexposed kidney, and transplantation with HCV-viremic kidney. We created race exemplar video clips describing these health states and randomly assigned patients into the race-matched or race-mismatched video arms. We obtained utilities for these 3 health states from each patient, and we evaluated knowledge about ESKD and HCV-associated health conditions with pre- and postintervention knowledge assessments.

Results

A total of 63 patients with hemodialysis from 4 outpatient Dialysis Center Inc sites completed the study. Mean adjusted standard gamble utilities for hemodialysis, transplant with HCV-unexposed kidney, and transplantation with HCV-viremic kidney were 82.5, 89, and 75.5, respectively. General group knowledge assessment scores improved by 10 points (P<.05) following utility assessment process. The use of race-matched exemplars had little effect on the results of the knowledge assessment of patients.

Conclusions

Using The Gambler II to collect utilities for patients with ESKD in an ambulatory dialysis clinic setting proved feasible. In addition, educational information about health states provided as part of the utility assessment process tool improved patients’ knowledge and understanding about ESKD-related health states and implications of organ transplantation with HCV-viremic kidneys. A wide variation in patient health state utilities reinforces the importance of incorporating patients’ preferences into decisions regarding use of HCV-viremic kidneys for transplantation.
Self-monitoring of Physical Activity After Hospital Discharge in Patients Who Have Undergone Gastrointestinal or Lung Cancer Surgery: Mixed Methods Feasibility Study
Authors: de Leeuwerk Marijke Elizabeth , Botjes Martine , van Vliet Vincent , Geleijn Edwin , de Groot Vincent , van Wegen Erwin , van der Schaaf Marike , Tuynman Jurriaan , Dickhoff Chris , van der Leeden Marike
Published: June 2022

Background

Self-monitoring of physical activity (PA) using an accelerometer is a promising intervention to stimulate PA after hospital discharge.

Objective

This study aimed to evaluate the feasibility of PA self-monitoring after discharge in patients who have undergone gastrointestinal or lung cancer surgery.

Methods

A mixed methods study was conducted in which 41 patients with cancer scheduled for lobectomy, esophageal resection, or hyperthermic intraperitoneal chemotherapy were included. Preoperatively, patients received an ankle-worn accelerometer and the corresponding mobile health app to familiarize themselves with its use. The use was continued for up to 6 weeks after surgery. Feasibility criteria related to the study procedures, the System Usability Scale, and user experiences were established. In addition, 6 patients were selected to participate in semistructured interviews.

Results

The percentage of patients willing to participate in the study (68/90, 76%) and the final participation rate (57/90, 63%) were considered good. The retention rate was acceptable (41/57, 72%), whereas the rate of missing accelerometer data was relatively high (31%). The mean System Usability Scale score was good (77.3). Interviewed patients mentioned that the accelerometer and app were easy to use, motivated them to be more physically active, and provided postdischarge support. The technical shortcomings and comfort of the ankle straps should be improved.

Conclusions

Self-monitoring of PA after discharge appears to be feasible based on good system usability and predominantly positive user experiences in patients with cancer after lobectomy, esophageal resection, or hyperthermic intraperitoneal chemotherapy. Solving technical problems and improving the comfort of the ankle strap may reduce the number of dropouts and missing data in clinical use and follow-up studies.
Effect of Switching Antiretroviral Treatment Regimen in Patients With Drug-Resistant HIV-1 Infection: Retrospective Observational Cohort Study (Preprint)
Authors: Li Yiping , Wang Qinjian , Liang Shu , Feng Chuanteng , Yang Hong , Yu Hang , Yuan Dan , Yang Shujuan
Published: June 2022

BACKGROUND

Evidence on the efficacy of antiretroviral therapy (ART) regimen switches on the mortality of patients with HIV drug resistance (HIVDR) is limited.

OBJECTIVE

We aim to provide policy guidance for ART regimen selection and evaluate the effectiveness of ART regime switches for people living with HIV and HIV-1 drug resistance.

METHODS

This retrospective observational cohort study included 179 people living with HIV and HIV-1 drug resistance from 2011 to 2020. The time that participants switched treatment regimens either to protease inhibitor (PI)–based ART regimens (PIs) or nonnucleoside reverse transcriptase inhibitor (NNRTI)–based ART regimens (NNRTIs) was taken as an observation starting point and followed up every 12 months. The parametric g-formula was used to estimate the 5-year risk of mortality under the situations of (1) natural course, (2) immediate switch to NNRTIs, (3) immediate switch to PIs, and (4) if CD4(+) T cells<200 switched to PIs.

RESULTS

The follow-up time of the 179 patients ranged from 30 to 119 months. The median follow-up time was 90 months. During a follow-up of 15,606 person-months, 27 individuals died in the cohort. The estimated 5-year risk of mortality under natural course, immediate switch to NNRTIs, immediate switch to PIs, and if CD4(+), and switch to PIs if T cells<200 were 11.62% (95% CI 7.82-17.11), 31.88% (95% CI 20.79-44.94), 2.87% (95% CI 0.32-7.07), and 5.30% (95% CI 2.07-10.21), respectively. The risk ratios (RRs) of immediate switch to NNRTIs, immediate switch to PIs, and switch to PIs if CD4(+) T cells<200, compared with natural course mortality rate, were 2.74 (95% CI 2.01-3.47), 0.25 (95% CI: 0.04-0.54), and 0.46 (95% CI 0.22-0.71), respectively. The risk differences were 20.26% (95% CI 10.96-28.61), –8.76% (95% CI –13.34 to –5.09) and –6.32% (95% CI –9.75 to –3.11), respectively.

CONCLUSIONS

Our study found that a PI-based ART regimen was beneficial for reducing mortality in people living with HIV and HIV-1 drug resistance. More effort should be given to find HIV-1 drug resistance earlier to ensure a timely adjustment to PI-based ART, thereby maximizing the benefit of early switch treatment for people living with HIV and HIV-1 drug resistance.
Quality of life of preschool children with psychomotor development disorders and their families. Availability of medical care and quality of its provision for this category of patients
Authors: Niankovskyy S.L. , Pushnyk A.I.
Published: June 2022

Background. Improving the quality of life of neurologicaly impaired child and his family is an issue of particular importance. The purpose of the study was to assess the quality of life of children with psychomotor development disorders and their families, the impact on the family of existing psychomotor disorders in children, as well as the availability of medical care and satisfaction with the quality of its provision to this category of patients; to identify the relationship between the calculated indicators of quality of life of children and their families and existing disorders of psychomotor development in children. Materials and methods. The study analyzed the results of the survey of 45 neurologically impaired preschool children’s parents. Results. A direct significant correlation of different strength was observed between the scores of the boys, their families and children’s neurological pathology. The correlation between the performance of the girls, their families and neurological disorders was mostly unreliable. This study also tested that the averages of the boys and their families were significantly higher than those of the girls in some sections of all questionnaires used. The rates of the children with mental retardation and their families mostly significantly exceeded the values of the children with other nosologies. The inverse correlation of different strength was verified between the indicators in the section The Parent HRQL Summary Score of the PedsQLTM 2.0 Family impact module questionnaire, the Total scores of the PedsQLTM Healthcare Satisfaction Generic Module questionnaire, the values in Psychosocial Health Summary section and the Total scores rates of the PedsQLTM 4.0 Generic Score Scales questionnaire in boys with mental retardation and in all examined boys, as well as in their families and neurological disorders. No correlation was found between the rates of the boys with ADHD and their neurological problems. Conclusions. The presence of direct and inverse reliable correlation of different strength between the average values of the examined boys with psychomotor development disorders, boys with mental retardation, as well as their families and the neurological pathology present in children was established. The correlation between the performance of the girls and their families and the neurological disorders of children in most sections is unreliable. It is necessary to conduct research with a larger number of participants.
Realisme Perspektival Edmund Husserl: Rekonstruksi Metafisik terhadap Teori Intensionalitas
Authors: Taufiqurrahman Taufiqurrahman
Published: June 2022

Posisi metafisik Edmund Husserl seringkali diperdebatkan di antara para komentatornya: apakah Husserl itu realis, idealis, atau netral secara metafisik. Alih-alih berambisi untuk membuat klaim yang terlalu umum tentang pemikiran Husserl, penelitian ini hanya fokus pada teori intensionalitas untuk mengetahui bagaimana komitmen metafisik Husserl di dalam teori tersebut. Penelitian ini, oleh karena itu, bertujuan untuk melakukan rekonstruksi metafisik terhadap teori intensionalitas Edmund Husserl dan kemudian membuktikan bahwa intensionalitas Husserlian lebih bercorak realis daripada idealis ataupun netral secara metafisik. Dengan menggunakan metode analisis tekstual terhadap karya-karya Husserl, penelitian ini setidaknya menghasilkan empat temuan. Pertama, intensionalitas kesadaran terhadap objeknya, dalam kerangka Husserlian, selalu dimediasi oleh makna. Kedua, objek intensi di dalam intensionalitas Husserlian itu bersifat transenden dan independen dari kesadaran. Ketiga, objek yang sama dapat diintensikan dengan mediasi makna yang berbeda-beda sesuai dengan perspektif yang menyituasikan intensi. Oleh karena itu, keempat, teori intensionalitas Husserl dapat dikategorikan sebagai salah satu versi dari realisme perspektival.
What is This Thing Called Adat Logic?
Authors: Firdaus Qusthan A. H.
Published: June 2022

The notion of adat (or custom) law does not encourage people in philosophy to reveal its logic. This article aims to investigate the possibility of adat logic, its variety, and a possible common ground or thesis among its own kinds. In general, the adat logic means the true contradiction between the rigidity and the reflexibility of custom. In other words, it resembles the idea of dialetheia in modern logic, but it does not mean that the adat logic is a subdivision of the former. To seek a thesis of adat logic is to discuss the Javanese and Minangkabaunese adat logics, and I transform both logics into some notations for the sake of avoiding unnecessary linguistic challenges and hurdles. Thus, I insert each notation of a particular adat logic into the general notation of adat logic. By doing so, I wish to discover a common ground between some different adat logics.
About New Path of School-based Cultural Propaganda Based on 5-FOCUS—Taking the New Media Platform of the Admissions and Employment Office of Southwest Petroleum University as an Example
Authors: Feng Yang , Yiyu Chen
Published: June 2022

With the steady progress of the new college entrance examination, the admissions work in colleges has ushered in new challenges and new opportunities. How to seize the opportunity in the increasingly fierce competition for students in colleges and universities, carry forward and publicize campus culture, and shape the school brand is the key. Relying on the new media platform, the Admissions and Employment Office of Southwest Petroleum University focuses on the theme of “energy confidence”, platform construction, mechanism construction, team building, function development, and original content through 5-FOCUS, so as to propaganda the culture and spirit in the colleges, and to continuously improve the recognition and social reputation of the parents of candidates.
Determinants of Saudi EFL Learners’ Beliefs about Learning EFL
Authors: Al-Seghayer Khalid
Published: June 2022

Language learners’ beliefs constitute an individual difference variable that profoundly influences language-learning behavior and significantly contributes to the process and ultimate success of language learning. This article identifies the beliefs Saudi learners hold about learning English as a foreign language (EFL). The analysis first addresses Saudi EFL learners’ perceptions of English, followed by a discussion of Saudi EFL learners’ experiences with learning English. The discussion also addresses these learners’ expectations about studying English and concludes by pinpointing the importance of understanding the distinct language-learning beliefs of Saudi EFL learners and highlighting all factors that could affect these beliefs. Moreover, this conceptual article offers measures and progressive ideas to consider that will help Saudi EFL teachers reinforce more productive and insightful language beliefs that have a facilitative effect on language learning and keep Saudi EFL learners from developing debilitative conceptions of language-learning beliefs. This work also highlights several research directions and pedagogical implications.
Cost–effectiveness of ensartinib for patients with anaplastic lymphoma kinase-positive non-small-cell lung cancer in China
Authors: Zhang Xudong , Fang Pingping , Su Guangquan , Gui Shuangying , Shen Aizong
Published: June 2022

Background:
Crizotinib and ensartinib improved survival in patients with
ALK
arrangement non-small-cell lung cancer (NSCLC); however, the economic outcomes of using ensartinib versus crizotinib are still unclear.
Aim:
The objective of this study was to assess the cost–effectiveness of ensartinib versus crizotinib for
ALK
-positive NSCLC patients from the perspective of China's healthcare system.
Methods:
A partitioned survival model with three health states (stable, progressive and death) was developed. Survival data were obtained from published eXalt3 clinical trials of ensartinib verses crizotinib for patients with anaplastic lymphoma kinase-positive non-small-cell lung cancer. Parametric models were used to extrapolate outcomes beyond the trial period. The drug cost comes from the local drug procurement platform. Other costs and utility values were obtained from published literature, and one-way and probabilistic sensitivity analyses were carried out to determine the robustness of the model outcomes.
Results:
In the whole life cycle, the average annual cost of ensatinib was US$77,636.63, and utility value was 5.5 quality adjusted life years (QALYs). Patients receiving crizotinib had 3.315QALYs and US$32,935.88 costs over the same time horizon. The incremental cost utility ratio is US$19,810.55/QALYs. In 2021, the per capita GDP of China is US$12,721.33, and the incremental cost utility is lower than the threshold of willingness to pay US$38,163.99.
Conclusion:
Compared with crizotinib, ensatinib is economical in the treatment of
ALK
-positive NSCLC and should be promoted.
Auranofin and Baicalin Inhibit Clostridioides difficile Growth and Sporulation: An In vitro Study
Authors: Madkour Lamiaa A.
Published: June 2022

Clostridioides difficile is a principal cause of hospital-acquired gastrointestinal infections, with sporulation and toxin production being key determinants in the disease pathogenesis. Although infections have been escalating and the complications can be life-threatening, the narrow pipeline of approved therapeutics has not witnessed an equivalent surge. With the unfolding of worrisome mutations and antimicrobial resistance, attention has been drawn to either discovering new therapeutics, or even better, repurposing already available ones. Consequently, this study was undertaken to assess the anti-clostridial activity of auranofin, an anti-rheumatic FDA-approved therapeutic; and baicalin, a natural flavone glycoside with reported anti-microbial potential. In comparison with vancomycin, the in vitro efficacy of auranofin and baicalin was tested against hypervirulent C. difficile (BAA-1870TM). Broth suspensions were prepared with and without the three agents and anaerobically incubated. At 24- and 48-hours post-incubation, serial dilutions were prepared and inoculated onto agar plates. Viable cell counts and viable spore counts were then quantified. Meanwhile, toxin production was assessed via ELISA. At a concentration as low as 3 μg/mL, auranofin demonstrated a potent anti-clostridial activity. Both auranofin and baicalin exhibited a remarkable reduction in C. difficile viable cell counts (P-value 0.03 for each) and spore counts (P-values 0.023 and 0.045 respectively). While auranofin and baicalin proved to be non-inferior to vancomycin as inhibitors of C. difficile growth, both drugs proved to be superior to vancomycin in decreasing the spore counts 48-hours post inoculation. Additionally, auranofin markedly reduced C. difficile toxin production (P-value 0.021); a feature that was deficient in both baicalin and vancomycin. To enrich the currently limited repertoire of anti-clostridial drugs, further research is encouraging to compare between the in vivo efficacy of auranofin and that of baicalin. Both agents represent promising approaches that could address the unfulfilled needs in controlling C. difficile infection.
A Review on Design Implementation and Verification of AMBA AXI- 4 lite Protocol for SoC Integration
Authors: N Hemanthraju
Published: June 2022

Abstract: The present modern bus protocols used for communication between different functional blocks on a System-on-Chip (Soc) designs face many different challenges among which complexity and communication management are the most important factors. These on-chip communications directly impact performance and functionality, hence depending on the application where the bus protocol is to be used, a perfect communication protocol is chosen. AMBA (Advanced Microcontroller Bus Architecture) provides various types of protocols to be used as IP, of which AXI4 (Advance Extensible Interface), is one of the widely used protocols for SoC designs. Out of its three different interconnect protocols: lite, stream and burst, AXI4-lite has the simplest architecture design that best suits to be used in applications where power, area and performance play a vital role. This paper briefs about using AMBA AXI4-lite bus protocol with more bus efficiency and performance in an SoC design for proper communication between various functional blocks present. The RTL is verified using UVM (Universal Verification Methodology) and various designing process is carried out using cadence tools.
Machine Learning
Authors: Kumar Ravit
Published: June 2022

Abstract: Machine Learning (M.L) is a scientific study of statical modals and algorithms that computer used to perform a certain task. Learning algorithms used in many applications that our used in daily life. Image recognition is a well known for identify an object as a digital image, one of the reason it work so well is because a learning algorithm that has based on the intensity of the pixels black & white images and color images. These algorithms are used for various purposes like predictive analytics, virtual assistants etc. The main advantage of using machine learning is that, once an algorithm grasp what to perform with particular data, then it works automatically.
LORA Based Wireless Weather Station
Authors: Reddy Katasani Vishnuvardhan
Published: June 2022

Abstract: In this Project we foster a model of "LoRa Based Wireless Weather Station". Where LoRa is a remote organization innovation supporting the web of things (IoT) framework. This innovation is an elective to other remote organization modules that have proactively been notable like GSM modules, Wi-Fi Modules and Bluetooth Modules. The use of the LoRa network expands the scope of remote cells that can arrive at distances of as much as 8 kilometres while as yet having low power usage. Climate boundaries that we are estimated in this task are Temperature, Pressure, Dew point, Altitude, Rainfall, Humidity and Light Intensity. In this model we use Arduino UNO, Barometric Sensor, Rain Sensor, Light Intensity Sensor and LoRa modules. What's more, Thingspeak Web application for sharing information to the clients. This framework can possibly be executed in metropolitan and provincial zones with various kinds of sensors related to it. This undertaking can be directed to shape a Low Power-Wide Area Network as a greater sensor organization.
Movie Recommendation System
Authors: J Jose Immanuvel.
Published: June 2022

Abstract: Movie recommendation system proposed whose primary objective is to suggest a recommended list through singular value decomposition collaborative filtering and cosine similarity. The present work improves these approaches by taking the movies’ content information into account during the item similarity calculations. The proposed approach recommends the top n recommendation list of movies to users on user’s interest preferences that were not already rated. Graphically shows the percentage of already viewed movies by user and movies recommended to User. Now a day’s recommendation system has changed the fashion of looking the items of our interest. OTT Movie Application Recommendation for mobile users is crucial. It performs a complete aggregation of user preferences, reviews and emotions to help you make suitable movies. It needs every precision and timeliness, however, this can be info filtering approach that’s accustomed predict the preference of that user. Recommender System may be a system that seeks to predict or filter preferences in keeping with the user’s selections. The very common purpose where recommender system is applied are OTT platforms, search engines, articles, music, videos etc. during this work we tend to propose a Collaborative approach-based Movie Recommendation system. It is supported collaborative filtering approach that creates use of the knowledge provided by users, analyzes them so recommends the flick that’s best suited to the user at that point.
Advanced Jacket for Military Defense and Social Welfare
Authors: Mohite Prof. T. H.
Published: June 2022

Abstract: As the climatic conditions are changing rapidly, the winters are getting much colder, especially in northern region and the western region of India. Since we developed a smart army jacket using control media devices such as, GPS, SENSORS in the jacket. The smart army jacket aims for providing reliable health monitoring as well as position tracking of soldier. Some of climatically conditions are led to unfortunate deaths of soldiers. This jacket can automatically sense the temperature inside, outside using temperature sensors. We are using coils for heating purpose and the temperature of the coil will depends on the outer temperature. GPS, the models used for communication purpose. Hence for monitoring the health and the heart rate of the soldier health monitoring equipment sensors are been establish in the jacket as well. In enemy territory soldiers not only have to deal with the physical threat, but also with stress and fatigue caused by protracted operations or lack of sleep. so for the security purpose we need a tool for remote soldier performance and health monitoring. so in this project a tool are implemented using bio medical sensors like heartbeat sensor, temperature sensor for health monitoring purpose by using the microcontroller.
Leadership-Focused Coaching in Action: An Approach to Continuous Improvement and Supporting Public Schools
Authors: Gray Julie A , Walker Aneta , Zimmerman Sherri , Dickson James
Published: June 2022

This article details the efforts of one program’s collaborative efforts toward continuous improvement and strengthening partnerships with local school districts using Leadership-Focused Coaching, a research-based model for principal preparation programs. Practical experiences and lessons learned from the ongoing online program improvement and redesign initiative are shared. In advance of two accreditation visits, data and feedback were gathered from partner districts, recent graduates, current students, and employers, which helped to identify ways in which the program could better prepare instructional leaders. This article describes the efforts, successes, setbacks, and future plans of a group of professors working to improve a program while preparing for accreditation visits and strengthening district partnerships.
Résumé Cet article détaille les efforts d’un programme spécifique de collaboration afin d’assurer une amélioration continue et un renforcement des partenariats avec des districts scolaires locaux au moyen du Leadership-Focused Coaching (coaching axé sur le leadership), lequel est un modèle basé sur la recherche pour les programmes visant à mieux former les directeurs d'école. Cet article partage les expériences et les leçons pratiques tirées d’une initiative en cours qui consiste à améliorer et reconcevoir le programme en ligne dont il est question dans l’article. Avant deux visites d'accréditation, des données et des commentaires ont été recueillis auprès de districts partenaires, de diplômés récents, d’étudiants actuels et d’employeurs, ce qui a permis d’identifier les moyens par lesquels le programme pourrait mieux préparer les leaders pédagogiques. En somme, cet article décrit les efforts, les succès, les revers et les projets d'un groupe de professeurs travaillant à l'amélioration d’un programme tout en se préparant aux visites d’accréditation et en renforçant les partenariats avec les districts.
Keywords / Mots clés : leadership preparation, university-school partnerships, leadership field experience, leadership-focused coaching, leadership mentoring / préparation au leadership, partenariats université-école, expérience de terrain en matière de leadership, coaching axé sur le leadership, mentorat en matière de leadership
Las tránsfugas de la clase alta argentina: experiencias formativas de quienes resisten un destino de privilegio
Authors: Gessaghi Victoria
Published: June 2022

Este artículo recupera una investigación centrada en el análisis de las trayectorias educativas de “la clase alta argentina” y se detiene en un referente empírico poco abordado por los estudios de la reproducción de la desigualdad: las experiencias formativas de aquellos que contando con todos los capitales para reproducir una posición de privilegio, rompen la continuidad social y se desclasan. A partir de un enfoque etnográfico, el artículo indaga en sus historias de vida y se interroga acerca de qué significa dejar de pertenecer a “la clase alta argentina”, cómo se abandona “una gran familia” y por qué es necesario un trabajo activo de los sujetos para lograr convertirse en un tránsfuga de clase alta. Documenta qué son las propias experiencias formativas de los sujetos en la trama singular del sistema educativo argentino la condición de posibilidad del desajuste necesario para instalar una discontinuidad en los procesos de reproducción social.
Between consensus and conflict: Schools and parents negotiating the educational trajectories of students at risk of early school leaving
Authors: Curran Marta
Published: June 2022

There is a vast amount of literature which locates the home-school relationship as a keystone to improving academic outcomes and preventing school dropouts. It is not always sufficiently clear, however, how these relationships are established and function and how they impact on students’ school engagement. This paper draws on the concepts of familial habitus and institutional habitus to better understand how home-school relationships are formed and how they are deeply class-biased. Using in-depth qualitative interviews with parents and teachers from four public secondary schools in Barcelona, this paper examines the factors explaining more and less harmonious relations between these two agents. This article will help shed light on the challenging relation between home and schools, taking into account different sociocultural contexts mediating this interaction and suggesting some implications in terms of educational policy from a social justice perspective.
categorías del juicio escolar en secundaria y la producción cotidiana del fracaso escolar
Authors: Rujas Martínez-Novillo Javier
Published: June 2022

Los discursos públicos sobre el fracaso escolar dicen poco sobre cómo se producen los “éxitos” y “fracasos” en la práctica cotidiana de las escuelas. Este trabajo analiza cómo se produce el juicio escolar en la educación secundaria obligatoria a partir de un trabajo de campo etnográfico (observación participante y entrevistas) en instituto público de un barrio popular. Muestra que el juicio escolar –y, con ello, los “éxitos” y “fracasos” escolares– es producto de un trabajo colectivo de categorización y jerarquización del alumnado. Los juicios cotidianos de los profesores movilizan diversas categorías o esquemas de percepción y apreciación incorporados: la presencia, la actitud, el comportamiento y la “disrupción”, la capacidad, el nivel. Su estudio revela que la educación secundaria, a pesar de las reformas comprensivas y la incorporación de nuevas categorías psicológicas al vocabulario docente, mantiene un fuerte carácter selectivo basado en una mezcla de ideología del don e ideología meritocrática.
La segregación escolar en familias inmigradas: clase social y estatus migratorio
Authors: Lubián Carlos , Langa Rosado Delia
Published: June 2022

Partimos de un estudio más amplio que analiza los factores residenciales y de gestión educativa que explican la segregación escolar étnica en el sistema educativo español. Nos centramos en este artículo en el papel de las familias como agentes, analizando sus estrategias de elección de centro mediante una metodología cualitativa de entrevistas en profundidad en la ciudad de Granada. Los resultados dibujan un escenario complejo que muestra: 1) Estrategias heterogéneas marcadas por la intersección entre clase, origen y etnia; 2) La importancia de factores propios del estatus migratorio en la toma de decisiones, como el capital étnico y el proyecto migratorio; 3) La influencia de factores contextuales, entre los que destaca una elevada movilidad escolar. Concluimos reflexionando sobre la capacidad de las familias migrantes para activar estrategias escolares situadas en procesos de segregación de los que no es fácil escapar.
MODEL OF STRESS-STRAIN STATE OF THREE-LAYERED REINFORCED CONCRETE STRUCTURE BY THE FINITE ELEMENT METHODS
Authors: Tho Vu Dinh , Korol Elena , Rimshin Vladimir , Anh Pham Tuan
Published: June 2022

The object of the study is multi-layer reinforced concrete structures of concrete with various physical and mechanical characteristics of materials - concrete and reinforcement under the influence of loading. Analysis of the stress state of multilayer reinforced concrete beams by using different materials is a complex problem due to the different mechanical and physical characteristics of materials and the cracking behavior of concrete. This article presents an analysis of the stress-strain state of three-layered reinforced concrete structures using the finite element method in the program ANSYS Mechanical. Numerical modeling allows on ANSYS allows combining different combinations of loads, the variability of the strength and deformation characteristics of materials and various types of reinforcement in multilayer reinforced concrete beams. Comparison is made between the experimental results, numerical results and finite element analyses with respect to initial crack formation and the ultimate load capacity of beams. The results of the study were shown that as the grade of concrete in the external layer increases from B15 to B20 and the grade of lightweight concrete in the internal layer increases from B0.75 to B1.5, the crack resistance can be increased by 59.7% and the bearing capacity of the test beam is increased by 16.4%. When the thickness of the external layers varies from 40mm to 80mm, making the crack resistance increased by 47.5% and the bearing capacity of three-layer concrete beams greatly increased by 6.7%. The obtained scientific results enable to determine rational parameters for modeling various structural solutions of multilayer reinforced concrete structures.
Kluyveromyces marxianus (Candida kefyr)
Authors: Noguera Melissa
Published: June 2022

Kluyveromyces marxianus
Reviewing Regulations on Rights of Persons with Disabilities in Vietnam to Advance the Implementation of the Convention on the Rights of People with Disabilities
Authors: Nghi Le Dinh
Published: June 2022

Viet Nam signed the International Convention on the Rights of Persons with Disabilities in 2007 and ratified it in 2014, recognizing all of the rights of PWDs included in the Convention without reservation. In addition, as a result of member states’ commitment, policies and legislation related to PWDs have been adjusted in order to adapt to socioeconomic developments in order to guarantee that PWDs can completely participate fully in society. However, there are relevant legal gaps between the 2010 Law on Persons with Disabilities and the International Convention on the Rights of Persons with Disabilities, particularly, in terms of obstacles, problems, and challenges in implementing rights to education, health care, and vocational training. Through analyzing the barriers, challenges, and legal gaps compared to the International Convention on the Rights of Persons with Disabilities, the article proposes some recommendations to ensure that Viet Nam fully implements its commitments under the Convention.
Privatisation of Power Generation in Malaysia: Impact on the Entry of Malays into Power Business
Authors: Thillainathan Ramasamy
Published: June 2022

This paper reviews Malaysia’s experience in privatisation in power generation from the first half of the 1990s and the role it played in promoting Malay entry into business. In the pre-1949 period, privately-owned independent power producers and distributors (IPPs and Ds) were the dominant players. The government-owned integrated power utility, Tenaga Nasional Berhad (TNB), became a monopoly only since 1976. TNB’s finances were strained during the Asian Financial Crisis (AFC) period, but contracts were honoured despite strong calls for renegotiation of power purchase agreements (PPA). With the open tender era from 2012, the PPA terms have become very competitive. However, as TNB can continue to bid, this has not made for a level playing field. With competition and fall in interest rate, there has been a significant decline in internal rate of returns (IRRs). Guaranteed off-take enabled some concessionaires to still earn a good equity IRR through aggressive gearing. Development of a more active and liquid bond market has played a key role in privatisation.