bluuebunny/crossref_metadata_2025 huggingface dataset:
Genomic Analyses Revealed the Genetic Difference and Potential Selection Genes of Growth Traits in Two Duroc Lines
Authors: Li Desen , Huang Min , Zhuang Zhanwei , Ding Rongrong , Gu Ting , Hong Linjun , Zheng Enqin , Li Zicong , Cai Gengyuan , Wu Zhenfang , Yang Jie
Published: September 2021

Duroc pigs are famous for their high growth rate, feed conversion efficiency, and lean meat percentage. Given that they have been subjected to artificial selection and breeding in multiple countries, various lines with obvious differences in production performance have formed. In this study, we genotyped 3,770 American Duroc (AD) pigs and 2,098 Canadian Duroc (CD) pigs using the GeneSeek Porcine SNP50 Beadchip to dissect the genetic differences and potential selection genes of growth traits in these two Duroc pig lines. Population structure detection showed that there were significant genetic differences between the two Duroc pig lines. Hence, we performedFSTand cross-population extended haplotype homozygosity (XP-EHH) analyses between the two lines. As a result, we identified 38 annotated genes that were significantly enriched in the gland development pathway in the AD line, and 61 annotated genes that were significantly enriched in the immune-related pathway in the CD line. For three growth traits including backfat thickness (BFT), loin muscle depth (LMD), and loin muscle area (LMA), we then performed selection signature detection at 5 and 10% levels within the line and identified different selected regions and a series of candidate genes that are involved in lipid metabolism and skeletal muscle development or repair, such asIRX3, EBF2, WNT10B, TLR2, PITX3, andSGCD. The differences in selected regions and genes between the two lines may be the cause of the differences in growth traits. Our study suggests significant genetic differences between the AD and CD lines, which provide a theoretical basis for selecting different Duroc lines as sires for different needs.
Vineyard Yield Estimation, Prediction, and Forecasting: A Systematic Literature Review
Authors: Barriguinha André , de Castro Neto Miguel , Gil Artur
Published: September 2021

Purpose—knowing in advance vineyard yield is a critical success factor so growers and winemakers can achieve the best balance between vegetative and reproductive growth. It is also essential for planning and regulatory purposes at the regional level. Estimation errors are mainly due to the high inter-annual and spatial variability and inadequate or poor performance sampling methods; therefore, improved applied methodologies are needed at different spatial scales. This paper aims to identify the alternatives to traditional estimation methods. Design/methodology/approach—this study consists of a systematic literature review of academic articles indexed on four databases collected based on multiple query strings conducted on title, abstract, and keywords. The articles were reviewed based on the research topic, methodology, data requirements, practical application, and scale using PRISMA as a guideline. Findings—the methodological approaches for yield estimation based on indirect methods are primarily applicable at a small scale and can provide better estimates than the traditional manual sampling. Nevertheless, most of these approaches are still in the research domain and lack practical applicability in real vineyards by the actual farmers. They mainly depend on computer vision and image processing algorithms, data-driven models based on vegetation indices and pollen data, and on relating climate, soil, vegetation, and crop management variables that can support dynamic crop simulation models. Research limitations—this work is based on academic articles published before June 2021. Therefore, scientific outputs published after this date are not included. Originality/value—this study contributes to perceiving the approaches for estimating vineyard yield and identifying research gaps for future developments, and supporting a future research agenda on this topic. To the best of the authors’ knowledge, it is the first systematic literature review fully dedicated to vineyard yield estimation, prediction, and forecasting methods.
Breeding for Prolificacy, Total Carotenoids and Resistance to Downy Mildew in Small-Ear Waxy Corn by Modified Mass Selection
Authors: Sukto Supaporn , Lomthaisong Khomsorn , Sanitchon Jirawat , Chankaew Sompong , Falab Shanerin , Lübberstedt Thomas , Lertrat Kamol , Suriharn Khundej
Published: September 2021

The study aimed to improve the small-ear waxy corn populations for prolificacy, high total carotenoid content and resistance to downy mildew. Three cycles of modified mass selection were carried out for population improvement. Forty-four genotypes derived from eight C3 populations and six check varieties were evaluated for agronomic traits and yield at Khon Kaen and screened for downy mildew resistance in the rainy season 2020 at two experimental sites in Ban Phang district of Khon Kaen province. Fifty genotypes were clustered into six major groups based on color parameter (h°) and total ear number. Two selected groups (C and E) with two populations of small-ear waxy corn including Nei9008/BK-24-9-B and TY/TF-33-1-B were selected as they were resistant to downy mildew, prolific ears, and intense orange kernel color. Modified mass selection was effective for improvement of multiple traits in waxy corn.
Composting and Methane Emissions of Coffee By-Products
Authors: San Martin Ruiz Macarena , Reiser Martin , Kranert Martin
Published: September 2021

In the last 20 years, the demand for coffee production has increased detrimentally, heightening the need for production, which is currently driving the increase in land cultivation for coffee. However, this increase in production ultimately leads to the amplification of waste produced. This study aims to develop an experimental methodology for sustainable coffee by-products (Pulp (CP)) in Costa Rica for nutrient-rich compost. The performance of the experiments is to explore and optimize composting processes following its key parameters. This will allow quantifying the emissions rate to obtain an emission factor for CP during the open composting process and optimizing the conditions to minimize CH4 emissions using P and green waste (GW) materials. Five CP and GW mixtures were analyzed for the composting process for ten weeks, acting P as primary input material as a by-product. Quantification of the methane emissions was performed in two areas: composting area and open field deposition. Peak temperatures of compost appeared at twenty-five days for control and five days for GW added treatments. CP emission factors provide a similar result with the standard values recommended by the literature, accomplishing the emission reductions. Thus, this study designed and validated a sustainable protocol for transforming coffee by-products into compost.
Decision Making under Risk in Patients Suffering from Schizophrenia or Depression
Authors: Benke Theresa , Marksteiner Josef , Ruepp Beatrix , Weiss Elisabeth M. , Zamarian Laura
Published: September 2021

Studies have reported difficulties in decision making for patients with schizophrenia or depression. Here, we investigated whether there are differences between schizophrenia patients, depressed patients, and healthy individuals (HC) when decisions are to be made under risk and cognitive flexibility is required. We were also interested in the relationships between decision making, cognitive functioning, and disease severity. Thirty HC, 28 schizophrenia patients, and 28 depressed patients underwent structured clinical assessments and were assessed by the Positive and Negative Syndrome Scale or Hamilton Rating Scale. They performed the Probability-Associated Gambling (PAG) Task and a neuropsychological test battery. Both patient groups obtained lower scores than HC in memory and executive function measures. In the PAG task, relative to HC, depressed patients made slower decisions but showed a comparable number of advantageous decisions or strategy flexibility. Schizophrenia patients were slower, riskier, and less flexible compared to HC. For them, the decision making behavior correlated with the symptom severity. In both groups, decision making scores correlated with memory and executive function scores. Patients with schizophrenia or depression may have difficulties under risk when quick and flexible decisions are required. These difficulties may be more pronounced in patients who have marked cognitive deficits or severe clinical symptoms.
Neutrophil Extracellular Traps (NETs) in Cancer Invasion, Evasion and Metastasis
Authors: Demkow Urszula
Published: September 2021

The present review highlights the complex interactions between cancer and neutrophil extracellular traps (NETs). Neutrophils constitute the first line of defense against foreign invaders using major effector mechanisms: phagocytosis, degranulation, and NETs formation. NETs are composed from decondensed nuclear or mitochondrial DNA decorated with proteases and various inflammatory mediators. Although NETs play a crucial role in defense against systemic infections, they also participate in non-infectious conditions, such as inflammation, autoimmune disorders, and cancer. Cancer cells recruit neutrophils (tumor-associated neutrophils, TANs), releasing NETs to the tumor microenvironment. NETs were found in various samples of human and animal tumors, such as pancreatic, breast, liver, and gastric cancers and around metastatic tumors. The role of the NETs in tumor development increasingly includes cancer immunoediting and interactions between the immune system and cancer cells. According to the accumulated evidence, NETs awake dormant cancer cells, causing tumor relapse, as well as its unconstrained growth and spread. NETs play a key regulatory role in the tumor microenvironment, such as the development of distant metastases through the secretion of proteases, i.e., matrix metalloproteinases and proinflammatory cytokines. NETs, furthermore, directly exacerbate tumor aggressiveness by enhancing cancer migration and invasion capacity. The collected evidence also states that through the induction of the high-mobility group box 1, NETs induce the epithelial to mesenchymal transition in tumor cells and, thereby, potentiate their invasiveness. NET proteinases can also degrade the extracellular matrix, promoting cancer cell extravasation. Moreover, NETs can entrap circulating cancer cells and, in that way, facilitate metastasis. NETs directly trigger tumor cell proliferation through their proteases or activating signals. This review focused on the pro-tumorigenic action of NETs, in spite of its potential to also exhibit an antitumor effect. NET components, such as myeloperoxidase or histones, have been shown to directly kill cancer cells. A better understanding of the crosstalk between cancer and NETs can help to devise novel approaches to the therapeutic interventions that block cancer evasion mechanisms and prevent metastatic spread. This review sought to provide the most recent knowledge on the crosstalk between NETs and cancer, and bring more profound ideas for future scientists exploring this field.
Induced Pluripotent Stem Cells to Model Juvenile Myelomonocytic Leukemia: New Perspectives for Preclinical Research
Authors: Wehbe Zeinab , Ghanjati Foued , Flotho Christian
Published: September 2021

Juvenile myelomonocytic leukemia (JMML) is a malignant myeloproliferative disorder arising in infants and young children. The origin of this neoplasm is attributed to an early deregulation of the Ras signaling pathway in multipotent hematopoietic stem/progenitor cells. Since JMML is notoriously refractory to conventional cytostatic therapy, allogeneic hematopoietic stem cell transplantation remains the mainstay of curative therapy for most cases. However, alternative therapeutic approaches with small epigenetic molecules have recently entered the stage and show surprising efficacy at least in specific subsets of patients. Hence, the establishment of preclinical models to test novel agents is a priority. Induced pluripotent stem cells (IPSCs) offer an opportunity to imitate JMML ex vivo, after attempts to generate immortalized cell lines from primary JMML material have largely failed in the past. Several research groups have previously generated patient-derived JMML IPSCs and successfully differentiated these into myeloid cells with extensive phenotypic similarities to primary JMML cells. With infinite self-renewal and the capability to differentiate into multiple cell types, JMML IPSCs are a promising resource to advance the development of treatment modalities targeting specific vulnerabilities. This review discusses current reprogramming techniques for JMML stem/progenitor cells, related clinical applications, and the challenges involved.
Structural Contribution of Cold In-Place Recycling Base Layer
Authors: Carvajal Mateo E. , Piratheepan Murugaiyah , Sebaaly Peter E. , Hajj Elie Y. , Hand Adam J.
Published: September 2021

Cold in-place recycling (CIR) of asphalt pavements is a process that has successfully been used for many years. The use of CIR for rehabilitation offers many advantages over traditional overlays due to its excellent resistance to reflective cracking and its environmentally friendly impacts. Despite the good performance and positive sustainability aspects of CIR, the structural contribution of the CIR base layer has not been well defined. In this research, CIR mixtures were designed with different asphalt emulsions. The mixtures were then subjected to dynamic modulus, repeated load triaxial, and flexural beam fatigue testing over a range of temperature and loading conditions. The performance test data generated were then used to develop CIR rutting and fatigue performance models used in the mechanistic analysis of flexible pavements. The technique used to develop the performance models leveraged the fact that the rutting and fatigue models for individual CIR mixtures were all within the 95 percent confidence interval of each other. A mechanistic analysis was conducted using the 3D-Move Mechanistic Analysis model. With the laboratory-developed performance models, the structural layer coefficient for the CIR base layer were developed for use in the 1993 AASHTO Guide for the Design of Pavement Structures. This analysis led to the determination of an average structural coefficient of the CIR base layer of 0.25.
Assessment of Central Sensitization in Breast Cancer Survivors: Convergent Validity and Use of the Central Sensitization Inventory (CSI) and Its Short-Form as a Clustering Tool
Authors: Hurth Alban , Nijzink-Ter Steege Jessica , Scheepbouwer Pauline , Roose Eva , Lahousse Astrid , Leysen Laurence , Stas Lara , Kregel Jeroen , Salvat Eric , Nijs Jo
Published: September 2021

The Central Sensitization Inventory (CSI) measurement properties in patients having nonspecific, noncancer pain are well-established. However, studies examining the reliability and validity of either the CSI or the Central Sensitization Inventory short-form version (CSI-9) in breast cancer survivors (BCS) are scarce. The purpose was to evaluate convergent validity and internal consistency of the CSI and CSI-9. Additionally, the relevance of a new cluster calculator using the CSI was explored. The cross-sectional multi-center study included 65 BCS and 37 healthy volunteers. Patients filled out multiple questionnaires assessing pain, number of painful areas, anxiety, depression and quality of life. The relevance of a cluster calculator was explored by known-group comparisons and boxplot description. All hypotheses were formulated before data analysis. The majority of hypotheses on the correlations between the CSI or CSI-9 and other health outcomes were confirmed (22 out of 27). The CSI and CSI-9 have excellent (α = 0.92) and good (α = 0.86) internal consistency, respectively. The CSI cluster calculator might be an interesting tool to use to have a patient’s overall condition snapshot. Generally, the study findings support the construct validity and internal consistency of the CSI, which underline the use of this self-reported instrument in BCS. The CSI-9 shows promising results, but should be further evaluated.
Optical Absorption in Si:H Thin Films: Revisiting the Role of the Refractive Index and the Absorption Coefficient
Authors: Müllerová Jarmila , Šutta Pavol , Holá Michaela
Published: September 2021

This paper reports on absorption properties of thin films of hydrogenated amorphous and microcrystalline silicon considered for absorption-based applications, such as solar cell, photodetectors, filters, sensors, etc. A series of four amorphous and four microcrystalline samples PECVD deposited under varied hydrogen dilution was under consideration. Various absorption metrics, based separately on the absorption coefficient and the refractive index (single pass absorption, optical path length, classical light trapping limit) or direct absorptance calculated by the Yablonovitch concept based on a mutual role of them were examined and compared. Differences in absorption abilities are related to the evolving thin film microstructure.
Intracoronary Thrombogenicity in Patients with Vasospastic Angina: An Observation Using Coronary Angioscopy
Authors: Teragawa Hiroki , Orita Yuichi , Oshita Chikage , Uchimura Yuko
Published: September 2021

Background: Despite significant interest in intracoronary thrombi in patients with vasospastic angina (VSA), the phenomenon remains unclarified. Therefore, we investigated a possible relationship using coronary angioscopy (CAS) in VSA patients. Methods: Sixty patients with VSA, for whom we could assess the spastic segment using CAS, were retrospectively studied. An intracoronary thrombus on CAS was a white thrombus and an erosion-like red thrombus. We verified the clinical characteristics and lesional characteristics as they determined the risk of intracoronary thrombus formation. Results: There were 18 (30%) patients with intracoronary thrombi. More of the patients with intracoronary thrombi were male, current smokers and had severe concomitant symptoms; however, no statistically significant difference was observed upon logistic regression analysis. There were 18 (26%) coronary arteries with intracoronary thrombi out of 70 coronary arteries recognised in the spastic segments. Furthermore, atherosclerotic changes and segmental spasms were significant factors responsible for such lesions. Conclusion: Intracoronary thrombi occurred in 30% of VSA patients and much attention should be paid to the intracoronary thrombogenicity of VSA patients.
Correction: Visani et al. miR-196B-5P and miR-200B-3P Are Differentially Expressed in Medulloblastomas of Adults and Children. Diagnostics 2020, 10, 265
Authors: Visani Michela , Marucci Gianluca , de Biase Dario , Giangaspero Felice , Buttarelli Francesca Romana , Brandes Alba Ariela , Franceschi Enrico , Acquaviva Giorgia , Ciarrocchi Alessia , Rhoden Kerry Jane , Tallini Giovanni , Pession Annalisa
Published: September 2021

The authors wish to make the following corrections to this paper [...]
Lung Function Decline in Adult Asthmatics—A 10-Year Follow-Up Retrospective and Prospective Study
Authors: Bucchieri Salvatore , Alfano Pietro , Audino Palma , Cibella Fabio , Fazio Giovanni , Marcantonio Salvatore , Cuttitta Giuseppina
Published: September 2021

Asthma may have an impact on lung function decline but conflicting results are reported in forced expiratory volume in one second (FEV1) decline. We aimed to describe the changes in FEV1 in lifelong non-smoking adult asthmatic outpatients during a 10-year follow-up comparing years 1–5 (1st period) with years 6–10 (2nd period) to assess factors affecting these changes. A total of 100 outpatients performed spirometry every 3 months during a 10-year survey. FEV1/Ht3 slope values of the 2nd period reduced significantly respect to the 1st period (p < 0.0001). FEV1 slopes of years 1–5 and 6–10 were inversely associated with FEV1 at enrolment (p = 0.02, p = 0.01, respectively). Reversibility and variability FEV1 showed a significant effect on the 1st period slopes (p = 0.01 and p < 0.04, respectively). Frequent exacerbators in the 1st year had steeper FEV1/Ht3 slopes in the 1st period (p = 0.01). The number of subjects using higher doses of ICS was significantly lower at the 10th years respect to the 5th and the 1st year (p < 0.001, p = 0.003, respectively). This study shows that FEV1 decline in treated adult asthmatics non-smokers, over 10-year follow-up, is not constant. In particular, it slows down over time, and is influenced by FEV1 at enrolment, reversibility, variability FEV1 and exacerbation score in the 1st year.
Insecure Attachment Styles and Unbalanced Family Functioning as Risk Factors of Problematic Smartphone Use in Spanish Young Adults: A Relative Weight Analysis
Authors: Mangialavori Sonia , Russo Claudia , Jimeno Maria Veronica , Ricarte Jorge Javier , D’Urso Giulio , Barni Daniela , Cacioppo Marco
Published: September 2021

Young adulthood is the life stage during which people are more prone to develop problematic smartphone use (PSU). Only one study investigated the relationship among attachment styles, family functioning, and PSU, but thus far, no research has shown the relative importance that such dimensions may have on PSU. The main aim of this study was to analyze to what extent insecure attachment styles and unbalanced family functioning are related to PSU, investigating the specific weight of each dimension in a sample of young adults (N = 301; 82.7% females; Mage = 22.89; SD = 3.02). Participants completed a self-report questionnaire, including the Relationship Questionnaire, the Family Adaptability and Cohesion Evaluation Scale IV, and the Smartphone Addiction Scale. The regression and relative weight analyses results showed that preoccupied attachment style and disengaged, chaotic, and enmeshed family functioning were positively related to PSU. Implications for future research and interventions were discussed.
A Synthesis of Spatial Forest Assessment Studies Using Remote Sensing Data and Techniques in Pakistan
Authors: Ahmad Adeel , Ahmad Sajid Rashid , Gilani Hammad , Tariq Aqil , Zhao Na , Aslam Rana Waqar , Mumtaz Faisal
Published: September 2021

This paper synthesizes research studies on spatial forest assessment and mapping using remote sensing data and techniques in Pakistan. The synthesis states that 73 peer-reviewed research articles were published in the past 28 years (1993–2021). Out of all studies, three were conducted in Azad Jammu & Kashmir, one in Balochistan, three in Gilgit-Baltistan, twelve in Islamabad Capital Territory, thirty-one in Khyber Pakhtunkhwa, six in Punjab, ten in Sindh, and the remaining seven studies were conducted on national/regional scales. This review discusses the remote sensing classification methods, algorithms, published papers’ citations, limitations, and challenges of forest mapping in Pakistan. The literature review suggested that the supervised image classification method and maximum likelihood classifier were among the most frequently used image classification and classification algorithms. The review also compared studies before and after the 18th constitutional amendment in Pakistan. Very few studies were conducted before this constitutional amendment, while a steep increase was observed afterward. The image classification accuracies of published papers were also assessed on local, regional, and national scales. The spatial forest assessment and mapping in Pakistan were evaluated only once using active remote sensing data (i.e., SAR). Advanced satellite imageries, the latest tools, and techniques need to be incorporated for forest mapping in Pakistan to facilitate forest stakeholders in managing the forests and undertaking national projects like UN’s REDD+ effectively.
Survey of Inoculated Commercial Saccharomyces cerevisiae in Winery-Based Trials
Authors: Duarte Filomena L. , Baleiras-Couto M. Margarida
Published: September 2021

Wine production has developed from spontaneous to controlled fermentations using commercial active dry yeasts (ADY). In this study, S. cerevisiae commercial ADY were tested, and yeast community dynamics were monitored at different fermentation stages in three winery-based trials with volumes ranging from 60 L to 250 hL. The differentiation of S. cerevisiae strains was achieved using microsatellite markers. In Experiment 1, results showed that both ADY strains revealed similar profiles, despite being described by the producer as having different properties. In Experiment 2, higher genetic diversity was detected when co-inoculation was tested, while in sequential inoculation, the initial ADY seemed to dominate throughout all fermentation. Pilot-scale red wine fermentations were performed in Experiment 3, where one single ADY strain was tested along with different oenological additives. Surprisingly, these trials showed an increase in distinct profiles towards the end of fermentation, indicating that the dominance of the ADY was lower than in the blank modality. The use of ADY is envisaged to promote a controlled and efficient alcoholic fermentation, and their purchase represents an important cost for wineries. Therefore, it is most relevant to survey commercial ADY during wine fermentation to understand if their use is effective.
User Authentication Based on Handwriting Analysis of Pen-Tablet Sensor Data Using Optimal Feature Selection Model
Authors: Begum Nasima , Akash Md Azim Hossain , Rahman Sayma , Shin Jungpil , Islam Md Rashedul , Islam Md Ezharul
Published: September 2021

Handwriting analysis is playing an important role in user authentication or online writer identification for more than a decade. It has a significant role in different applications such as e-security, signature biometrics, e-health, gesture analysis, diagnosis system of Parkinson’s disease, Attention-deficit/hyperactivity disorders, analysis of vulnerable people (stressed, elderly, or drugged), prediction of gender, handedness and so on. Classical authentication systems are image-based, text-dependent, and password or fingerprint-based where the former one has the risk of information leakage. Alternatively, image processing and pattern-analysis-based systems are vulnerable to camera attributes, camera frames, light effect, and the quality of the image or pattern. Thus, in this paper, we concentrate on real-time and context-free handwriting data analysis for robust user authentication systems using digital pen-tablet sensor data. Most of the state-of-the-art authentication models show suboptimal performance for improper features. This research proposed a robust and efficient user identification system using an optimal feature selection technique based on the features from the sensor’s signal of pen and tablet devices. The proposed system includes more genuine and accurate numerical data which are used for features extraction model based on both the kinematic and statistical features of individual handwritings. Sensor data of digital pen-tablet devices generate high dimensional feature vectors for user identification. However, all the features do not play equal contribution to identify a user. Hence, to find out the optimal features, we utilized a hybrid feature selection model. Extracted features are then fed to the popular machine learning (ML) algorithms to generate a nonlinear classifier through training and testing phases. The experimental result analysis shows that the proposed model achieves more accurate and satisfactory results which ensure the practicality of our system for user identification with low computational cost.
Effects of Wildfire and the Presence of the Invasive Paulownia tomentosa on the Regeneration of Native Tree Species in North-Central Appalachia
Authors: Williams Roger , Wang Haibin
Published: September 2021

A wildfire occurred in Shawnee State Forest located in southern Ohio that consumed 1215 hectares. Based on earlier forest inventories it was known that paulownia (Paulownia tomentosa), a non-native invasive tree species, occurred in the forest. The objective of this study was to determine if paulownia heavily colonized areas two years after the fire where the burn occurred, and if its presence had a negative impact on the regeneration (<137 cm height) of native species—red and white oaks (Quercus sp.), red maple (Acer rubrum), and yellow-poplar (Liriodendron tulipifera). Two years after the fire, paulownia had invaded the burned areas but not at significantly higher densities than occurred in the unburned areas. Fire significantly reduced the number of regenerating stems of white oak and red maple two years after the fire, whereas the number of regenerating stems of red oak increased slightly and that of yellow-poplar increased significantly. In areas where paulownia occurred that experienced wildfire, all species studied displayed a reduction in the number of regenerating stems compared to paulownia’s absence in the burn areas. Where paulownia occurred in areas not affected by the wildfire, all the native species studied displayed a reduction in the number of regenerating stems. The average heights of red oak, white oak, and red maple were significantly taller when growing in areas affected by the wildfire due to a more open canopy. However, there was no significant change in the average heights of yellow-poplar. The presence of paulownia in both the burned and unburned areas reduced the number of regenerating stems of the native species studied.
Pore-Scale Simulation of the Interaction between a Single Water Droplet and a Hydrophobic Wire Mesh Screen in Diesel
Authors: Elsayed Omar , Kirsch Ralf , Krull Fabian , Antonyuk Sergiy , Osterroth Sebastian
Published: September 2021

Recently, the trend towards sustainable energy production and pollution control has motivated the increased consumption of ultra-low-sulfur diesel (ULSD) or bio-fuels. Such fuels have relatively low surface tension with water and therefore, the separation of water from fuel has become a challenging problem. The separation process relies on using porous structures for the collection and removal of water droplets. Hence, understanding the interaction between water droplets and the separators is vital. The simplest geometry of a separator is the wire mesh screen, which is used in many modern water–diesel separators. Thus, it is considered here for systematic study. In this work, pore-scale computational fluid dynamics (CFD) simulations were performed using OpenFOAM® (an open-source C++ toolbox for fluid dynamics simulations) coupled with a new accurate scheme for the computation of the surface tension force. First, two validation test cases were performed and compared to experimental observations in corresponding bubble-point tests. Second, in order to describe the interaction between water droplets and wire mesh screens, the simulations were performed with different parameters: mean diesel velocity, open area ratio, fiber radii, Young–Laplace contact angle, and the droplet radius. New correlations were obtained which describe the average reduction of open surface area (clogging), the pressure drop, and retention criteria.
A q-Gradient Descent Algorithm with Quasi-Fejér Convergence for Unconstrained Optimization Problems
Authors: Mishra Shashi Kant , Rajković Predrag , Samei Mohammad Esmael , Chakraborty Suvra Kanti , Ram Bhagwat , Kaabar Mohammed K. A.
Published: September 2021

We present an algorithm for solving unconstrained optimization problems based on the q-gradient vector. The main idea used in the algorithm construction is the approximation of the classical gradient by a q-gradient vector. For a convex objective function, the quasi-Fejér convergence of the algorithm is proved. The proposed method does not require the boundedness assumption on any level set. Further, numerical experiments are reported to show the performance of the proposed method.
Trusting the Trust Game: An External Validity Analysis with a UK Representative Sample
Authors: Banerjee Sanchayan , Galizzi Matteo , Hortala-Vallve Rafael
Published: September 2021

Using a nationally representative sample of 1052 respondents from the United Kingdom, we systematically tested the associations between the experimental trust game and a range of popular self-reported measures for trust, such as the General Social Survey (GSS) and the Rosenberg scale for self-reported trust. We find that, in our UK representative sample, the experimental trust game significantly and positively predicts generalised self-reported trust in the GSS. This association is robust across a number of alternative empirical specifications, which account for multiple hypotheses corrections and control for other social preferences as measured by the dictator game and the public good game, as well as for a broad range of individual characteristics, such as gender, age, education, and personal income. We discuss how these results generalise to nationally representative samples from six other Organisation for Economic Co-operation and Development (OECD) countries (France, Germany, Italy, Korea, Slovenia, and the US).
Custody Transfers of Children and Young Adults in Foster Care
Authors: Blomé Helen , Espvall Majen
Published: September 2021

The high-profile case of “Little Heart”, a 3-year-old girl who, shortly after being reunited with her biological parents, was found dead in her home, has contributed to strengthening the rights of children placed in foster care in Sweden. However, the stability of children placed in foster care is not a new issue. In the last decade, the number of custody transfers has more than doubled. In this study, critical discourse analysis was used to study which discourses on children’s needs and parental rights had guided 89 district court decisions. The results show that custody transfer takes place at a younger age and is still based on an adult perspective, and children’s voices and wishes are often overlooked. The dominant discourses in the submissions of the social services, as well as in the district court decisions, are about continuity, connection, and security, concepts and formulations that are replicated from the preparatory work for the legislation. This study demonstrates the need for expertise and reflection in custody investigations into how questions are asked and how the responses are conveyed, as well as the need to intensify and strengthen the work of making children involved and heard in accordance with the aims of the Children’s Convention.
Functional Status among Polymedicated Geriatric Inpatients at Discharge: A Population-Based Hospital Register Analysis
Authors: Pereira Filipa , Wernli Boris , von Gunten Armin , Carral María del Rio , Martins Maria Manuela , Verloo Henk
Published: September 2021

This study explored and compared the functional status of polymedicated and non-polymedicated geriatric inpatients at hospital discharge. We used a cross-sectional registry of geriatric patients’ hospital records from a multi-site public hospital center in Switzerland. The analysis included all inpatients aged 65 years old or more admitted between 1 January 2015 and 31 December 2017 (n = 53,690), of whom 67.5% were polymedicated at hospital discharge, 52.1% were women (n = 18,909), and 42.7% were 75–84 years old (n = 15,485). On average, the polymedicated patients’ hospital lengths of stay were six days longer, they presented with more than three comorbidities, and they were prescribed more than nine medications at hospital discharge (p < 0.001). They showed more frequent general mobility decline (43.2% vs. 41.9%), gait disorders (46.2% vs. 43%), fatigue (48.6% vs. 43.4%) and dependence on lower-body care (49.7% vs. 47.6%), and presented a higher malnutrition risk (OR = 1.411; 95%CI 1.263–1.577; p < 0.001). However, the non-polymedicated inpatients had proportionally more physical and cognitive impairments. The comparison of the functional status of polymedicated and non-polymedicated geriatric inpatients at hospital discharge is important for clinicians trying to identify and monitor those who are most vulnerable to functional decline, and to design targeted strategies for the prevention of functional impairment and related adverse health outcomes.
Drugs Becoming Generics—The Impact of Genericization on the Market Performance of Antihypertensive Active Pharmaceutical Ingredients
Authors: Kovács Bence , Darida Miklós , Simon Judit
Published: September 2021

To explore long-term changes in intra and inter-class choices between generic compounds, this paper investigates the market trends of two antihypertensive drug classes that have closely related pharmacological mechanisms—angiotensin convertase enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). We analysed the development of ACEI and ARB markets between 2001 and 2016 in nine European countries, covering the genericization transition periods of both therapeutic groups. The analysis was undertaken on the level of the active pharmaceutical ingredients (API) and focused on international and country-specific diffusion patterns. Comparison of ARB and ACEI therapies shows that although ARBs became off-patent during the observed period, and have a clinical advantage in terms of the adverse event profile over ACEIs, the increasing dominance of ARBs cannot be identified. One explanation is that ACEI therapies became generics earlier, relocating competition to the level of brands, while competition among ARBs remained at the level of the APIs. As for intra-class drug preferences, it was observed that the long-term trends show that ramipril outperformed its ACEI competitors, even though the kinetics and the rank order of preferred active compounds were inconsistent among markets. The diffusion of clinically preferable therapies seems to be ultimately supported by generic entries. In Eastern European countries, the emergence of generic markets has not only improved access to ACE inhibitors and ARBs, but has been a prerequisite for changing preferences. In contrast, genericization resulted in the relative anchoring of prior, branded era-based preferences in some Western European countries, which may be attributed to the role of the cessation of promotion and the fixity of prescription behaviour.
Obesity and Thyroid Axis
Authors: Walczak Krzysztof , Sieminska Lucyna
Published: September 2021

Development of obesity is primarily the result of imbalance between energy intake and energy expenditure. Thyroid hormones influence energy expenditure by regulating cellular respiration and thermogenesis and by determining resting metabolic rate. Triiodothyronine influences lipid turnover in adipocytes and impacts appetite regulation through the central nervous system, mainly the hypothalamus. Thyroid-stimulating hormone may also influence thermogenesis, suppress appetite and regulate lipid storage through lipolysis and lipogenesis control. Subclinical hypothyroidism may induce changes in basal metabolic rate with subsequent increase in BMI, but obesity can also affect thyroid function via several mechanisms such as lipotoxicity and changes in adipokines and inflammatory cytokine secretion. The present study investigated the complex and mutual relationships between the thyroid axis and adiposity.
Empowering Patients and Supporting Health Care Providers—New Avenues for High Quality Care and Safety
Authors: Busch Isolde Martina , Rimondini Michela
Published: September 2021

A large body of research suggests that establishing and strengthening patient–provider relationships, characterized by transparency, respect, trust, and empathy, is highly beneficial for patients, their caregivers, and healthcare providers [...]
Time-Series Assessment of Camp-Type Artisanal and Small-Scale Gold Mining Sectors with Large Influxes of Miners Using LANDSAT Imagery
Authors: Kimijima Satomi , Sakakibara Masayuki , Nagai Masahiko , Gafur Nurfitri Abdul
Published: September 2021

Mining sites development have had a significant impact on local socioeconomic conditions, the environment, and sustainability. However, the transformation of camp-type artisanal and small-scale gold mining (ASGM) sites with large influxes of miners from different regions has not been properly evaluated, owing to the closed nature of the ASGM sector. Here, we use remote sensing imagery and field investigations to assess ASGM sites with large influxes of miners living in mining camps in Bone Bolango Regency, Gorontalo Province, Indonesia, in 1995–2020. Built-up areas were identified as indicators of transformation of camp-type ASGM sites, using the Normalized Difference Vegetation Index, from the time series of images obtained using Google Earth Engine, then correlated with the prevalent gold market price. An 18.6-fold increase in built-up areas in mining camps was observed in 2020 compared with 1995, which correlated with increases in local gold prices. Field investigations showed that miner influx also increased after increases in gold prices. These findings extend our understanding of the rate and scale of development in the closed ASGM sector and the driving factors behind these changes. Our results provide significant insight into the potential rates and levels of socio-environmental pollution at local and community levels.
Worldwide Research Trends in Landslide Science
Authors: Carrión-Mero Paúl , Montalván-Burbano Néstor , Morante-Carballo Fernando , Quesada-Román Adolfo , Apolo-Masache Boris
Published: September 2021

Landslides are generated by natural causes and by human action, causing various geomorphological changes as well as physical and socioeconomic loss of the environment and human life. The study, characterization and implementation of techniques are essential to reduce land vulnerability, different socioeconomic sector susceptibility and actions to guarantee better slope stability with a significant positive impact on society. The aim of this work is the bibliometric analysis of the different types of landslides that the United States Geological Survey (USGS) emphasizes, through the SCOPUS database and the VOSviewer software version 1.6.17, for the analysis of their structure, scientific production, and the close relationship with several scientific fields and its trends. The methodology focuses on: (i) search criteria; (ii) data extraction and cleaning; (iii) generation of graphs and bibliometric mapping; and (iv) analysis of results and possible trends. The study and analysis of landslides are in a period of exponential growth, focusing mainly on techniques and solutions for the stabilization, prevention, and categorization of the most susceptible hillslope sectors. Therefore, this research field has the full collaboration of various authors and places a significant focus on the conceptual evolution of the landslide science.
In Silico Screening of Novel α1-GABAA Receptor PAMs towards Schizophrenia Based on Combined Modeling Studies of Imidazo [1,2-a]-Pyridines
Authors: Zheng Xiaojiao , Wang Chenchen , Zhai Na , Luo Xiaogang , Liu Genyan , Ju Xiulian
Published: September 2021

The ionotropic GABAA receptor (GABAAR) has been proven to be an important target of atypical antipsychotics. A novel series of imidazo [1,2-a]-pyridine derivatives, as selective positive allosteric modulators (PAMs) of α1-containing GABAARs with potent antipsychotic activities, have been reported recently. To better clarify the pharmacological essentiality of these PAMs and explore novel antipsychotics hits, three-dimensional quantitative structure–activity relationships (3D-QSAR), molecular docking, pharmacophore modeling, and molecular dynamics (MD) were performed on 33 imidazo [1,2-a]-pyridines. The constructed 3D-QSAR models exhibited good predictive abilities. The dockings results and MD simulations demonstrated that hydrogen bonds, π–π stackings, and hydrophobic interactions play essential roles in the binding of these novel PAMs in the GABAAR binding pocket. Four hit compounds (DS01–04) were then screened out by the combination of the constructed models and computations, including the pharmacophore model, Topomer Search, molecular dockings, ADME/T predictions, and MD simulations. The compounds DS03 and DS04, with higher docking scores and better predicted activities, were also found to be relatively stable in the binding pocket by MD simulations. These results might provide a significant theoretical direction or information for the rational design and development of novel α1-GABAAR PAMs with antipsychotic activities.
Design Parameter Influence on Losses and Downstream Flow Field Uniformity in Supersonic ORC Radial-Inflow Turbine Stators
Authors: Cappiello Alessandro , Tuccillo Raffaele
Published: September 2021

The design of organic Rankine cycle (ORC) turbines often requires dealing with transonic flows due to the cycle efficiency requirements and the matching of the temperature profiles with heat sources and sinks, as well as the nature of organic fluids, often featuring high molecular weight. Consequently, the use of convergent–divergent turbine stators has been widely established as a solution in the published literature for use in both axial- and radial-inflow machines. With respect to the latter layout in particular, the available design guidelines are still limited. The present work shows the results of an investigation into a series of ORC radial-inflow convergent–divergent nozzles that differ with respect to the vane count and the designed metal angle of the outlet. These stators were designed by fitting the divergent portion of a sharp-edged minimum-length nozzle, designed by means of the method of characteristics (MoC) adapted to dense gases, into a radial-inflow turbine stator. The geometries were analysed by means of steady-state RANS CFD calculations, and the results were used to assess the influence of the design parameters on the nozzle losses and downstream flow field uniformity, showing that conflicting trends exist between optimum stator efficiency and optimum downstream flow field uniformity.
Pollen Diet—Properties and Impact on a Bee Colony
Authors: Bryś Maciej Sylwester , Skowronek Patrycja , Strachecka Aneta
Published: September 2021

Diet is an important factor in the proper development of the individual and the entire colony. A pollen diet affects honey bees in a number of ways. It can stimulate the number and type of hemocytes, the total number of proteins, carbohydrates and lipids, affect the histology of the middle intestine, and ensure the correct ontogenesis of the larvae. Moreover, selected single-flower diets can stimulate the development of the pharyngeal glands that produce royal jelly, thus conditioning the development of secretory immunity. Selected single-species pollen may also increase the phenol oxidase concentration, which contributes to the humoral response. A honey bee diet based on multi-flower pollen is more desirable than a mono-flower diet, but must be properly balanced.
Varroa destructor from the Laboratory to the Field: Control, Biocontrol and IPM Perspectives—A Review
Authors: Vilarem Caroline , Piou Vincent , Vogelweith Fanny , Vétillard Angélique
Published: September 2021

Varroa destructor is a real challenger for beekeepers and scientists: fragile out of the hive, tenacious inside a bee colony. From all the research done on the topic, we have learned that a better understanding of this organism in its relationship with the bee but also for itself is necessary. Its biology relies mostly on semiochemicals for reproduction, nutrition, or orientation. Many treatments have been developed over the years based on hard or soft acaricides or even on biocontrol techniques. To date, no real sustainable solution exists to reduce the pressure of the mite without creating resistances or harming honeybees. Consequently, the development of alternative disruptive tools against the parasitic life cycle remains open. It requires the combination of both laboratory and field results through a holistic approach based on health biomarkers. Here, we advocate for a more integrative vision of V. destructor research, where in vitro and field studies are more systematically compared and compiled. Therefore, after a brief state-of-the-art about the mite’s life cycle, we discuss what has been done and what can be done from the laboratory to the field against V. destructor through an integrative approach.