bluuebunny/crossref_metadata_2025 huggingface dataset:
Future research directions for accessible social media
Authors: Gleason Cole , Carrington Patrick , Chilton Lydia B. , Gorman Benjamin , Kacorri Hernisa , Monroy-Hernández Andrés , Morris Meredith Ringel , Tigwell Garreth , Wu Shaomei
Published: July 2020

Social media platforms are deeply ingrained in society, and they offer many different spaces for people to engage with others. Unfortunately, accessibility barriers prevent people with disabilities from fully participating in these spaces. Social media users commonly post inaccessible media, including videos without captions (which are important for people who are Deaf or Hard of Hearing) and images without alternative text (descriptions read aloud by screen readers for people who are blind). Users with motor impairments must find workarounds to deal with the complex user interfaces of these platforms, and users with cognitive disabilities may face barriers to composing and sharing information.

We invited accessibility researchers, industry practitioners, and end-users with disabilities to come together at the Computer-Supported Cooperative Work conference (CSCW 2019) to discuss challenges and solutions for improving social media accessibility. Over the course of a day that included two panels and breakout sessions, the workshop attendees outlined four critical future research directions to progress on the path to accessible social media: tooling to support disabled people authoring content, developing more accessible formats/tools for new forms of interaction (e.g, Augmented and Mixed Reality), using communities to distribute accessibility labor, and ensuring machine learning systems are built on representative datasets for disability use-cases.
Studies of the SEI layers in Li(Ni0.5Mn0.3Co0.2)O2/Artificial Graphite Cells after Formation and after Cycling
Authors: Keefe A. S. , Weber Rochelle , Hill I. G. , Dahn J. R.
Published: July 2020

Li(Ni0.5Mn0.3Co0.2)O2/artificial graphite cells containing different electrolyte additives were studied using electrochemical impedance spectroscopy (EIS) and X-ray photoelectron spectroscopy (XPS) after formation and after long-term charge-discharge cycling. Positive and negative electrodes were examined separately in symmetric cells to study the solid electrolyte interphase (SEI) at each electrode. EIS measurements were taken vs temperature, and activation energies (Ea) related to Li+ transport through the SEI were calculated. After cycling, Ea differed depending on electrolyte additive, electrode type, and cycling voltage limits. Charge transfer resistance was also compared after formation and cycling and did not always correlate with Ea trends, suggesting that multiple factors influence SEI properties. XPS was used to study the chemical composition and thickness of the SEI. Electrolyte additives affected the quantity of inorganic materials in the SEI, and more inorganic material appeared to correlate with lower Ea values. Cells containing lithium difluorophosphate electrolyte additive had the best lifetime of the cells studied in this work. These cells also showed the lowest SEI activation energy values, lowest charge transfer resistance, and most inorganic SEI composition after cycling.
Accelerated Kidney Aging in Diabetes Mellitus
Authors: Guo Jing , Zheng Hui Juan , Zhang Wenting , Lou Wenjiao , Xia Chenhui , Han Xue Ting , Huang Wei Jun , Zhang Fan , Wang Yaoxian , Liu Wei Jing
Published: July 2020

With aging, the kidney undergoes inexorable and progressive changes in structural and functional performance. These aging-related alterations are more obvious and serious in diabetes mellitus (DM). Renal accelerated aging under DM conditions is associated with multiple stresses such as accumulation of advanced glycation end products (AGEs), hypertension, oxidative stress, and inflammation. The main hallmarks of cellular senescence in diabetic kidneys include cyclin-dependent kinase inhibitors, telomere shortening, and diabetic nephropathy-associated secretory phenotype. Lysosome-dependent autophagy and antiaging proteins Klotho and Sirt1 play a fundamental role in the accelerated aging of kidneys in DM, among which the autophagy-lysosome system is the convergent mechanism of the multiple antiaging pathways involved in renal aging under DM conditions. Metformin and the inhibitor of sodium–glucose cotransporter 2 are recommended due to their antiaging effects independent of antihyperglycemia, besides angiotensin-converting enzyme inhibitors/angiotensin receptor blockers. Additionally, diet intervention including low protein and low AGEs with antioxidants are suggested for patients with diabetic nephropathy (DN). However, their long-term benefits still need further study. Exploring the interactive relationships among antiaging protein Klotho, Sirt1, and autophagy-lysosome system may provide insight into better satisfying the urgent medical needs of elderly patients with aging-related DN.
Integrated Bioinformatic Analysis Identifies Networks and Promising Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma
Authors: Ji Yun , Yin Yue , Zhang Weizhen
Published: July 2020

Chronic infection with hepatitis B virus (HBV) has long been recognized as a dominant hazard factor for hepatocellular carcinoma (HCC) and accounts for at least half of HCC instances globally. However, the underlying molecular mechanism of HBV-linked HCC has not been completely elucidated. Here, three microarray datasets, totally containing 170 tumoral samples and 181 adjacent normal tissues from the liver of patients suffering from HBV-related HCC assembled from the Gene Expression Omnibus (GEO) database, were subjected to integrated analysis of differentially expressed genes (DEGs). Subsequently, the analysis of function and pathway enrichment as well as the protein-protein interaction network (PPI) was performed. The ten hub genes screened out from the PPI network were further subjected to expression profile and survival analysis. Overall, 329 DEGs (67 upregulated and 262 downregulated) were identified. Ten DEGs with the highest degree of connectivity included cyclin-dependent kinase 1 (CDK1), cyclin B1 (CCNB1), cyclin B2 (CCNB2), PDZ-binding kinase (PBK), abnormal spindle microtubule assembly (ASPM), nuclear division cycle 80 (NDC80), aurora kinase A (AURKA), targeting protein for xenopus kinesin-like protein 2 (TPX2), kinesin family member 2C (KIF2C), and centromere protein F (CENPF). Kaplan-Meier analysis unveiled that overexpression levels of KIF2C and TPX2 were relevant to both the poor overall survival and relapse-free survival. In summary, the hub genes validated in the present study may provide promising targets for the diagnosis, prognosis, and therapy of HBV-associated HCC. Additionally, our work uncovers various crucial biological components (e.g., extracellular exosome) and signaling pathways that participate in the progression of HCC induced by HBV, serving comprehensive knowledge of the mechanisms regarding HBV-related HCC.
Maternal Satisfaction with Antenatal Care and Associated Factors among Pregnant Women in Hossana Town
Authors: Kebede Dagmawit Birhanu , Belachew Yeshitila Belay , Selbana Desta Workneh , Gizaw Admasu Belay
Published: July 2020

Background. A woman’s satisfaction with antenatal care service has immediate and long-term impacts on maternal and her baby’s health. It also ensures further use of service. However, it is not well studied in Ethiopia in general and at the southern region in particular. Objective. The main objective of this study is to assess the level of a maternal satisfaction with antenatal care services and associated factors. Methods. An institution-based cross-sectional study that involves both quantitative and qualitative methods of data collection was employed. A systematic sampling technique was used to obtain study participants, and quantitative data were collected using an interviewer-administered questionnaire. For qualitative data, Focus Group Discussions were done among clients that have a repeated visit by taking educational status as homogeneity criteria. EpiData version 3.1 and SPSS version 21 were used for analysis. Descriptive statistics, bivariate and multivariable logistic regression analyses were employed to describe and identify factors associated with maternal satisfaction on antenatal care. The qualitative data were analyzed thematically and manually. Results. Overall, 74% of mothers were satisfied with antenatal care services rendered in public health institutions of Hossana town. Most of the respondents were satisfied with privacy, cleanness, physical facility, and approaches of care. Age, educational status, privacy, cleanness, distance, and respect were significantly associated with a client’s satisfaction. Conclusion. Three-fourths of the respondents were satisfied with the service. Age, education, living distance, maintenance of privacy, cleanness of the facility, and respect from providers were the significant predictors of the satisfaction level.
Cardiac Arrest and Successful Extracorporeal Cardiopulmonary Resuscitation as a Result of a Refeeding Syndrome in a Young Female with Anorexia Nervosa
Authors: Waddell Daniela , Meincke Felix , Hakmi Samer , van der Schalk Hendrick , Schenker Niklas , Hahn Jonas , Moschner Anna , Bohné Mintje , Chung Da-Un , Willems Stephan , Kivelitz Dietmar , Bahlmann Edda
Published: July 2020

Anorexia nervosa is a potentially life-threatening eating disorder, characterized by an abnormally low body weight. This case report illustrates a 22-year old female with cardiac arrest due to a refeeding syndrome in a patient with anorexia nervosa. It features the successful use of extracorporeal cardiopulmonary resuscitation in a case of severe left ventricular dysfunction resulting in a favorable outcome.Conclusion. We present the first case of a cardiac arrest due to a refeeding syndrome in anorexia nervosa featuring the successful use of an extracorporeal cardiopulmonary resuscitation approach as a bridge to full recovery.
A Study of the Differences in the Gas Diffusion and Migration Characteristics of Soft and Hard Coal in High Gas Coal Seams
Authors: Yuan Anying
Published: July 2020

At the present time, it is of major significance to examine the differences in the gas diffusion and migration characteristics of soft and hard coal in order to prevent and control safety hazards in high gas coal seams. In this study, the differences in the gas diffusion and migration characteristics between soft coal and hard coal were examined in detail using macrostructural, mesostructural, and microstructural research methods. The root causes of the differences in the gas diffusion and migration between soft coal and hard coal were revealed in the obtained research results. The study shows that, in terms of the macrostructures, the soft coal particle grains were flakey and with shapes resembling fingernails. Meanwhile, the hard coal particle grains were observed to be in the shapes of complete blocks. In addition, in terms of the mesostructures of the different coal types, it was found that the proportion of granular coal below the particle size limit of 6 mm in the soft coal was much higher than that of the hard coal. Also, from the aspect of the characteristics of the microstructures, the pores and fissures on the soft coal surfaces were observed to be better developed, and the BJH specific surface areas of the soft coal were more than twice those of the hard coal. That is to say, the gas diffusion and migration conditions of the soft coal were better than those of the hard coal. At the same time, the increments of the specific surface areas and volumes of the pores of soft coal were above 100 nm, which provided channels for gas diffusion and migration at rates of more than twice those of the hard coal. Therefore, the soft coal was more conducive to gas emissions. This study conducted gas desorption experiments on both soft and hard coal samples and found that the initial gas desorption speed of the soft coal was significantly higher than that of the hard coal. Since the instantaneous gas emissions of the soft coal were significantly higher than those of the hard coal, it was considered to be more likely that gas outbursts and transfinite accidents could potentially occur in the soft coal layers of a project site. This study’s results provided a foundation and basis for effective gas control measures in coal seams composed of soft coal layers, which will be of major significance to the safety of coal mining activities in the future.
Study on the Parameter Optimization and Strength Mechanism of Coal Gangue Emulsified Asphalt Mixture
Authors: Liu ZhanLiang , Zhang Chen , Qu Xin
Published: July 2020

Emulsified asphalt mixture has the characteristics of convenient construction and durable performance, but its poor early strength and demulsification seriously restrict the popularization and application of this material. At present, the coal gangue produced by coal‐fired power plants is generally discarded, resulting in serious environmental pollution. The combination of coal gangue and emulsified asphalt can explore an efficient utilization way for more and more coal gangue and also solve the curing problem of asphalt. In order to give full play to the advantages of existing materials and make rational use of resources, this paper studies the factors affecting the performance of coal gangue emulsified asphalt mixture based on orthogonal experimental design and optimizes its material composition parameters by considering the coupling effect of two factors. The water stability of coal gangue emulsified asphalt mixture is evaluated by the immersion Marshall test. Finally, the strength formation mechanism of coal gangue emulsified asphalt mixture is analyzed from the microscopic point of view. The results determined 7.5% as the optimum amount of emulsified asphalt in coal gangue emulsified asphalt mixture and recommended the best parameter combination of 7.5% emulsified asphalt, 6% coal gangue, and 5% water consumption. With the increase of coal gangue content, the water loss resistance of emulsified asphalt mixture increases gradually, and the water stability of emulsified asphalt mixture can be improved by adding coal gangue. According to the microscopic analysis, the strength of the mixture is formed by the joint action of emulsified asphalt and coal gangue, in which the hydration products of coal gangue and asphalt play the role of cementation and strength together. The ordinary emulsified asphalt mortar mainly contains CaCO3, which mainly plays the role of physical filling.
Focal Segmental Glomerulosclerosis: State-of-the-Art and Clinical Perspective
Authors: Shabaka Amir , Tato Ribera Ana , Fernández-Juárez Gema
Published: July 2020

Focal segmental glomerulosclerosis (FSGS) is a histological pattern of glomerular injury, rather than a single disease, that is caused by diverse clinicopathological entities with different mechanisms of injury with the podocyte as the principal target of lesion, leading to the characteristic sclerotic lesions in parts (i.e., focal) of some (i.e., segmental) glomeruli. The lesion of FSGS has shown an increasing prevalence over the past few decades and is considered the most common glomerular cause leading to ESKD. Primary FSGS, which usually presents with nephrotic syndrome, is thought to be caused by circulating permeability factors that have a main role in podocyte foot process effacement. Secondary forms of FSGS include maladaptive FSGS secondary to glomerular hyperfiltration such as in obesity or in cases of loss in nephron mass, virus-associated FSGS, and drug-associated FSGS that can result in direct podocyte injury. Genetic FSGS is increasingly been recognized and a careful evaluation of patients with atypical primary or secondary FSGS should be performed to exclude genetic causes. Unlike primary FSGS, secondary and genetic forms of FSGS do not respond to immunosuppression and tend not to recur after kidney transplantation. Distinguishing primary FSGS from secondary and genetic causes has a prognostic significance and is crucial for an appropriate management. In this review, we examine the pathogenesis, clinical approach to distinguish between the different causes, and current recommendations in the management of FSGS.
Nephrology Provider Surprise Question Response and Hospitalizations in Older Adults with Advanced CKD
Authors: Ramer Sarah J. , Baddour Nicolas A. , Siew Edward D. , Salat Huzaifah , Bian Aihua , Stewart Thomas G. , Wong Susan P.Y. , Jhamb Manisha , Abdel-Kader Khaled
Published: July 2020

Background: Older adults with advanced non-dialysis-dependent chronic kidney disease (NDD-CKD) face a high risk of hospitalization and related adverse events. Methods: This prospective cohort study followed nephrology clinic patients ≥60 years old with NDD-CKD stages 4-5. After an eligible patient’s office visit, study staff asked the patient’s provider to rate the patient’s risk of death within the next year using the surprise question (“Would you be surprised if this patient died in the next 12 months?”) with a 5-point Likert scale response (1, “definitely not surprised” to 5, “very surprised”). We used a statewide database to ascertain hospitalization during follow-up. Results: There were 488 patients (median age 72 years, 51% female, 17% black) with median estimated glomerular filtration rate 22 mL/min/1.73 m2. Over a median follow-up of 2.1 years, the rates of hospitalization per 100 person-years in the respective response groups were 41 (95% confidence interval [CI]: 34–50), “very surprised”; 65 (95% CI: 55–76), “surprised”; 98 (95% CI: 85–113), “neutral”; 125 (95% CI: 107–144), “not surprised”; and 120 (95% CI: 94–151), “definitely not surprised.” In a fully adjusted cumulative probability ordinal regression model for proportion of follow-up time spent hospitalized, patients whose providers indicated that they would be “definitely not surprised” if they died spent a greater proportion of follow-up time hospitalized compared with those whose providers indicated that they would be “very surprised” (odds ratio 2.4, 95% CI: 1.0–5.7). There was a similar association for time to first hospitalization. Conclusion: Nephrology providers’ responses to the surprise question for older patients with advanced NDD-CKD were independently associated with proportion of future time spent hospitalized and time to first hospitalization. Additional studies should examine how to use this information to provide patients with anticipatory guidance on their possible clinical trajectory and to target potentially preventable hospitalizations.
Obesity: An Independent Predictor of Morbidity and Graft Loss after Kidney Transplantation
Authors: Aziz Fahad , Ramadorai Anand , Parajuli Sandesh , Garg Neetika , Mohamed Maha , Mandelbrot Didier A. , Foley David P. , Garren Michael , Djamali Arjang
Published: July 2020

Background: There is conflicting information on current medical and surgical complications associated with high body mass index (BMI) after kidney transplantation. Methods: In a single-center observational study, we analyzed the 5-year outcomes of all consecutive primary kidney transplant recipients between 2010 and 2015 based on BMI at the time of transplant. Results: There were 1,467 patients included in this study, distributed in the following groups based on BMI: underweight (n = 32, 2.2%), normal (n = 407, 27.7%), overweight (n = 477, 32.5%), grade I obesity (n = 387, 26.4%), grade II obesity (n = 155, 10.6%), and grade III obesity (n = 9, 0.6%). Obesity was associated with an increased incidence of delayed graft function (p = 0.008), length of stay (LOS, p = 0.03), 30-day surgical re-exploration (p = 0.02), and hospital readmission (p < 0.0001). Obesity was also associated with higher 1-year serum creatinine (p = 0.03) and increased 5-year incidence of cardiac events (p < 0.0001) and congestive heart failure (p < 0.0001). Multivariable Cox regression analyses determined grade III obesity (HR = 5.84, 95% CI: 1.40–24.36, p = 0.01), LOS >4 days (HR = 1.94, 95% CI: 1.19–3.18, p = 0.008), hospital readmission (HR = 2.25, 95% CI: 1.20–4.22, p = 0.01), 1-year serum creatinine >1.5 (HR = 1.95, 95% CI: 1.20–3.18, p = 0.007), and proteinuria (UPC) >1 g/g (HR = 1.85, 95% CI: 1.06–3.24, p = 0.03) as independent predictors of death-censored graft failure. Conclusion: In the current era of renal transplant care, obesity is common, and high BMI remains associated with significant medical and surgical complications after transplant.
Association between Ultrafiltration Rate and Clinical Outcome Is Modified by Muscle Mass in Hemodialysis Patients
Authors: Lim Yuntac , Yang Gyeonghun , Cho Seong , Kim Sung Rok , Lee Yu-Ji
Published: July 2020

Background: The association between ultrafiltration rate (UFR) and mortality may be affected by the muscle mass or volume status in hemodialysis (HD) patients. However, there is an absence of data regarding this association. Methods: We performed an observational study on patients (≥18 years old) who had been on HD for at least 3 months. A body composition monitor (BCM) was used for baseline bioimpedance analysis measurement. The primary composite outcome was defined as the time to death or the first cardiovascular event. Results: The median (interquartile range) UFR, volume excess measured by the BCM, and lean tissue index (LTI) (calculated as lean tissue mass/height2) were 11.4 (8.0–15.0) mL/h/kg, 2.4 (1.4–4.1) L, and 12.5 (10.4–14.4) kg/m2, respectively. During 284 person-years of follow-up, the primary outcome occurred in 44 of the 167 patients (26%). Higher UFR was associated with an increased outcome of death or cardiovascular event; the adjusted hazard ratio (HR) was 1.044 (95% confidence interval [CI]: 1.006–1.083). This association remained consistent even after adjusting for volume excess. However, the association between UFR and the primary outcome was modified by LTI (pinteraction = 0.027); the association was significant in patients with LTI < 12.5 kg/m2, and the HR (95% CI) was 1.050 (1.001–1.102). Conclusion: Higher UFR was associated with an increased risk of a composite outcome of death or cardiovascular event regardless of volume status in HD patients. However, muscle mass may modify the association between higher UFR and increased risk of a composite outcome.
Family History of Atrial Fibrillation and Risk of Cardiovascular Events
Authors: Pastori Daniele , Menichelli Danilo , Lip Gregory Y.H. , Sciacqua Angela , Violi Francesco , Pignatelli Pasquale , Saliola Mirella , Casciaro Marco Antonio , Rende Greta , Vicario Tommasa , Del Sole Francesco , Bucci Tommaso
Published: July 2020

Background:

To investigate the association between family history of atrial fibrillation (AF) with cardiovascular events (CVEs), major adverse cardiac events (MACE), and cardiovascular mortality.

Methods:

Multicenter prospective observational cohort study including 1722 nonvalvular AF patients from February 2008 to August 2019 in Italy. Family history of AF was defined as the presence of AF in a first-degree relative: mother, father, sibling, or children. Primary outcome was a composite of CVEs including fatal/nonfatal ischemic stroke and myocardial infarction, and cardiovascular death. Second, we analyzed the association with major adverse cardiac event.

Results:

Mean age was 74.6±9.4 years; 44% of women. Family history of AF was detected in 368 (21.4%) patients, and 3.5% had ≥2 relatives affected by AF. Age of AF onset progressively decreased from patients without family history of AF, compared with those with single and multiple first-degree affected relatives (
P
<0.001). During a mean follow-up of 23.7 months (4606 patients/y) 145 CVEs (3.15%/y), 98 major adverse cardiac event (2.13%/y), and 57 cardiovascular deaths (0.97%/y) occurred. After adjustment for cardiovascular risk factors, family history of AF was associated with a higher risk of CVEs (hazard ratio, 1.524 [95% CI, 1.021–2.274],
P
=0.039), major adverse cardiac event (hazard ratio, 1.917 [95% CI, 1.207–3.045],
P
=0.006), and cardiovascular mortality (hazard ratio, 2.008 [95% CI, 1.047–3.851],
P
=0.036). Subgroup analysis showed that this association was modified by age, sex, and prior ischemic heart disease.

Conclusions:

In a cohort of elderly patients with a high atherosclerotic burden, family history of AF is evident in >20% of patients and was associated with an increased risk for CVEs and mortality.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01882114.
Models of communication and control for brain networks: distinctions, convergence, and future outlook
Authors: Srivastava Pragya , Nozari Erfan , Kim Jason Z. , Ju Harang , Zhou Dale , Becker Cassiano , Pasqualetti Fabio , Pappas George J. , Bassett Danielle S.
Published: July 2020

Recent advances in computational models of signal propagation and routing in the human brain have underscored the critical role of white-matter structure. A complementary approach has utilized the framework of network control theory to better understand how white matter constrains the manner in which a region or set of regions can direct or control the activity of other regions. Despite the potential for both of these approaches to enhance our understanding of the role of network structure in brain function, little work has sought to understand the relations between them. Here, we seek to explicitly bridge computational models of communication and principles of network control in a conceptual review of the current literature. By drawing comparisons between communication and control models in terms of the level of abstraction, the dynamical complexity, the dependence on network attributes, and the interplay of multiple spatiotemporal scales, we highlight the convergence of and distinctions between the two frameworks. Based on the understanding of the intertwined nature of communication and control in human brain networks, this work provides an integrative perspective for the field and outlines exciting directions for future work.
Hydaticus aequalis sp. n. and a new record of H. devexus Trémouilles, 1996 from Brazil (Coleoptera, Dytiscidae, Hydaticini)
Authors: BENETTI CESAR J. , GUSTAFSON GREY T. , HAMADA NEUSA , SHORT ANDREW EDWARD Z.
Published: July 2020

Hydaticus aequalis sp. n. is described from Brazil, where it was recently discovered in the central lowlands region of the Amazon forest. The new species differs from all other Neotropical congeners by its uniformly brown dorsal surface and the shape of medial lobe. The dorsal habitus and male genitalia are illustrated, and a distribution map is provided. The habitat, a small stream and associated forest pool, is illustrated and described. In addition, a new record of H. devexus Trémouilles, 1996, previously known from a single specimen, is reported from the highlands of northeastern Brazil, and a modified key to Neotropical species of the genus is provided.
A new species of Mastiglanis Bockmann 1994 (Siluriformes: Heptapteridae) from the Amazon River basin, Peru
Authors: FAUSTINO-FUSTER DARIO R. , ORTEGA HERNÁN
Published: July 2020

Mastiglanis is a genus of heptapterid catfish represented by two valid species. These freshwater species are widely distributed along the Amazon, Orinoco, and Maroni River basins. However, a taxonomic review of specimens collected in the Putumayo and Nanay rivers, Amazon River basin in Peru revealed a new species of Mastiglanis. A morphological analysis was completed for morphometric (36 measurements) and meristic (20 counts) data. Osteological counts and descriptions were made from clear and stained specimens and x-rays images. The new species of Mastiglanis differs from M. asopos and M. durantoni by having a long pelvic fin, short snout, eight branched anal-fin rays, and a higher number of vertebrae and gill rakers. The distribution of the new species is restricted to the upper Amazon River basin.
Two new species of the Amphinemura sinensis group (Plecoptera: Nemouridae) from southern China
Authors: MO RAORAO , WANG GUOQUAN , YANG DING , LI WEIHAI , MURÁNYI DÁVID
Published: July 2020

Two new species of the genus Amphinemura in the sinensis species group, A. retusilobata sp. n. and A. simifleurdelia sp. n. are proposed from Guangdong Province and Guangxi Zhuang Autonomous Region of southern China, based on adults of both sexes. The new species are compared to related taxa and distribution map for the A. sinensis group is given.
Processing of high strength Mg–9Gd–3Nd–1Sn–1Zn–0.6Zr alloy by hot rolling and subsequent aging
Authors: Yan Zehua , Yu Yandong , Sang Yanchao , Yao Yiming , Qian Jiahao
Published: July 2020

Magnesium alloy plates can be strengthened by rolling, however, it is easy to crack or even break when the reduction of Mg–RE alloys is too large. Herein, the strengthening mechanical of the Mg–9Gd–3Nd–1Sn–1Zn– 0.6Zr alloy under different treatment
conditions were investigated after hot-rolling to 80% reduction in thickness (0.8 mm) by multi-step methods. Furthermore, the rolled alloy by aging strengthening are explored. The results show that the hot-rolled alloy with 80% reduction are basically composed of dynamically recrystallized
grains with the size of about 60 m, improving the mechanical properties significantly. The precipitates within grains undergo SSSS→ β″ → β′ phase transformation with the aging treatment up to 200 °C. Fine β″ precipitates were found
in the grains of the rolled alloy under aged time (2 h), while β″ precipitates changed into β′ phase when the aging time was extended to 32 h. The base phase which is perpendicular to phase was precipitated in the alloy in longer aging time (96 h). In addition,
the thickness of precipitates and precipitation-free zone (PFZ) at the grain boundary gradually increased as the time went on. Meanwhile, the discontinuous equilibrium phases at the grain boundary are gradually become continuous. The ultimate tensile strength and hardness were reached to 431.14
MPa, 105.9 HV at peak-aging, in addition, the elongation is reached to 3.11%, respectively. The formation of crack sources is due to the stress concentration between the brittle PFZ and the magnesium matrix, which leads to the decrease of ductility.
The clinical effect of Chitosan nanoparticles against Helicobacter pylori
Authors: Wang Jing , Wang Xinhong , Li Min , Fan Suxiang
Published: July 2020

The objective of this study was to observe the clinical effect of Chitosan nanoparticles therapy on Helicobacter pylori (HP) infection. Three treatment groups (A, B, and control group C) were randomly assigned with 60 cases of HP each, making 180 cases. Group C received standard
triple therapy (omeprazole + amoxicillin + clarithromycin), group A got a routine dose of Chitosan nanoparticles plus triple therapy, and group B got a high dose of Chitosan nanoparticles plus triple therapy. The course of treatment in each group was 7 days. The eradication rate, clinical
efficacy and adverse reactions were observed. Up to 172 patients finished the experiment, with 59 patients in Group A, 57 in Group B and 56 in Group C. In a total analysis set (FAS), the eradication rates of HP in Group A, Group B and Group C were 80.00%, 80.70%, and 71.67%, respectively.
There was no significant difference between the two groups (P > 0.05). In accordance with the PPS, the HP eradication rates of group A, B, and C were 81.36%, 80.70% and 76.79%, respectively, and there was no significant difference between the two groups (P > 0.05). The
clinical efficacy of group A, B, and C were 91.67%, 91.23%, and 70.00%, respectively. The differences among the three groups were statistically significant (P < 0.05). In accordance with the PPS, the clinical efficacy of group A, B and C was 93.22%, 91.23%, and 75.00%, respectively.
With a P-value of less than 0.05, the results indicated that the difference between the two groups was statistically significant. There were 21 adverse reactions in the experiment, including 3 in group A, 6 in group B, and 12 in group C. The difference was statistically significant
(P < 0.05) between group A and B compared with group C, the difference was statistically significant (P < 0.05); the difference between group A and group B was statistically significant (P < 0.05). In conclusion the therapeutic effect of Chitosan nanoparticles
and oral liquid, combined with triple therapy on HP infection is satisfactory, with less adverse reactions are. However, the findings suggest that it is not desirable to use a high dose Chitosan nanoparticles and oral liquid.
Superoleophilic polyurethane sponge for highly efficient oil/water separation
Authors: Li Xianfeng , Lin Bo , Zheng Chen , Li Zhimin , Wang Peng , Liu Guocong
Published: July 2020

A superoleophilic polyurethane sponge had been constructed by means of an immersion method in an ethanol solution of n-octadecyltrichlorosilane. SEM, FTIR, TGA, and XPS unanimously confirmed that PODS had been successfully coated onto the skeleton of polyurethane sponge. The
PODS-modified sponge displayed both excellent hydrophobicity with high water contact angle of 152° and good oil affinity. The PODS-modified sponge took the high adsorptive capabilities for the silicone oil, toluene, and peanut oil with 62.1, 73.7, and 98.2 g · g–1
after 50 cycles of extrusion-release, respectively. The superoleophilic sponge in this work exhibited promising opportunities on the oil/water separation and the oil spill remediation.
Analysis on sliding wear behavior of Al + B4C+ mica hybrid metal matrix composites
Authors: Velavan K. , Palanikumar K.
Published: July 2020

In this investigation, wear behavior of hybrid aluminum metal matrix composites (HMMCs) fabricated by stir casting technique is carried out. Boron carbide and Mica particles are added. The Mica percentage varies from 3–5% in steps of 1% with a constant reinforcement quantity of
10% boron carbide. The dry sliding wear experiments are explored on a pin on disc tribometer. The process variables considered for the study are: Mica mass fraction, sliding speed, load and sliding time, and the response analyzed is wear loss. Box-Behnken design is used for conducting the
experiments. The result shown proves that 3% of Mica particle inclusion reduces the wear due to the increase in density. Further increase of mica does not improve the wear resistance. ANOVA results indicate that load and % of Mica are the profoundly influencing parameters. The pin surface
is analyzed by using a Scanning Electron Microscope.
Evaluation of low molecular weight polyethylenimine-introduced chitosan for gene delivery to mesenchymal stem cells
Authors: Liu Minchen , Hu Yulan , Feng Yi
Published: July 2020

This study aimed to examine the transfection ability of polyethylenimine (PEI) (1800 Da)-grafted chitosan (10 kDa) (CP), a newly synthesized PEI derivative, in mesenchymal stem cells (MSCs). The safety evaluation of the complex/DNA was studied in vitro and in vivo. In
addition, CP/pGL3 was applied to investigate the effects of transfection efficiency. In this study, CP/DNA can be formed with compatible physicochemical characteristics for gene delivery. CP cytotoxicity decreased in A549 cells. Moreover, a zebrafish embryo model was used for evaluating the
safety in vivo. Compared to the PEI (25 kDa) group, the zebrafish hatching rate increased and the mortality rate decreased in the CP/DNA group, which provided an indication of the safety of CP. In comparison with chitosan (100 kDa)-PEI (1200 Da), CP's transfection efficiency was higher
in both A549 cells and MSCs. This study aimed to lay the foundation for further applications of CP in gene delivery. Therefore, further gene therapy investigations of CP by using MSCs need to be performed.
Global Pattern Formation of Net Ocean Surface Heat Flux Response to Greenhouse Warming
Authors: Hu Shineng , Xie Shang-Ping , Liu Wei
Published: July 2020

This study examines global patterns of net ocean surface heat flux changes (ΔQnet) under greenhouse warming in an ocean–atmosphere coupled model based on a heat budget decomposition. The regional structure of ΔQnetis primarily shaped by ocean heat divergence changes (ΔOHD): excessive heat is absorbed by higher-latitude oceans (mainly over the North Atlantic and the Southern Ocean), transported equatorward, and stored in lower-latitude oceans with the rest being released to the tropical atmosphere. The overall global pattern of ΔOHD is primarily due to the circulation change and partially compensated by the passive advection effect, except for the Southern Ocean, which requires further investigations for a more definitive attribution. The mechanisms of North Atlantic surface heat uptake are further explored. In another set of global warming simulations, a perturbation of freshwater removal is imposed over the subpolar North Atlantic to largely offset the CO2-induced changes in the local ocean vertical stratification, barotropic gyre, and the Atlantic meridional overturning circulation (AMOC). Results from the freshwater perturbation experiments suggest that a significant portion of the positive ΔQnetover the North Atlantic under greenhouse warming is caused by the Atlantic circulation changes, perhaps mainly by the slowdown of AMOC, while the passive advection effect can contribute to the regional variations of ΔQnet. Our results imply that ocean circulation changes are critical for shaping global warming pattern and thus hydrological cycle changes.
Analyzing the Arctic Feedback Mechanism between Sea Ice and Low-Level Clouds Using 34 Years of Satellite Observations
Authors: Philipp Daniel , Stengel Martin , Ahrens Bodo
Published: July 2020

Satellite-based cloud, radiation flux, and sea ice records covering 34 years are used 1) to investigate autumn cloud cover trends over the Arctic, 2) to assess its relation with declining sea ice using Granger causality (GC) analysis, and 3) to discuss the contribution of the cloud–sea ice (CSI) feedback to Arctic amplification. This paper provides strong evidence for a positive CSI feedback with the capability to contribute to autumnal Arctic amplification. Positive low-level cloud fractional cover (CFClow) trends over the Arctic ice pack are found in October and November (ON) with magnitudes of up to about +9.6% per decade locally. Statistically significant anticorrelations between sea ice concentration (SIC) and CFCloware observed in ON over melting zones, suggesting an association. The GC analysis indicated a causal two-way interaction between SIC and CFClow. Interpreting the resultingFstatistic and its spatial distribution as a relation strength proxy, the influence of SIC on CFClowis likely stronger than the reverse. ERA-Interim reanalysis data suggest that ON CFClowis impacted by sea ice melt through surface–atmosphere coupling via turbulent heat and moisture fluxes. Due to weak solar insolation in ON, net cloud radiative forcing (CRF) exerts a warming effect on the Arctic surface. Increasing CFClowinduces a large-scale surface warming trend reaching magnitudes of up to about +8.3 W m−2per decade locally. Sensitivities of total CRF to CFClowranges between +0.22 and +0.66 W m−2per percent CFClow. Increasing surface warming can cause a melt season lengthening and hinders formation of perennial ice.
Temperature-Induced Chemical Changes in Lubricant Automotive Oils Evaluated Using Raman Spectroscopy
Authors: de M. Bezerra Andressa Cristina , de A. Coelho Nelize Maria , Bertelli Felipe , Pacheco Marcos Tadeu T. , Silveira Landulfo
Published: July 2020

Automotive engine lubricating oils are not only intended to reduce friction between parts, but also act on the cooling of motor components and protection of metals against corrosion. To improve its properties and efficiency, additives are added to the base oil for different goals. However, over time of use, external factors modify its properties, such as the engine operating temperature, the frictional force between parts, the mixture of this oil with fuel before burning and with combustion products, causing loss of their efficiency. This work aimed to evaluate, with Raman spectroscopy technique, the temperature-induced changes related to degradation of mineral, semi-synthetic and synthetic automotive lubricating oils. Samples being subject to periodic heating cycle were kept to average temperature of 133 ℃, considering 8 h per day, for six days, until complete 48 h of heating. By analyzing the Raman spectra, it was possible to identify common peaks between the three types of oils and changes caused by heating cycles. Principal components analysis showed that the synthetic oil degraded in less extent than the semi-synthetic one, and this one degraded less than the mineral oil. Spectral models to predict the heating time based on the spectral variations identified using principal components analysis and the regression done using partial least squares, using the heating time as independent variable and the spectral features as dependent variables, was able to predict the heating time for each of oil types with high correlation and prediction error ( r > 0.97 and error <4.0 h) for both principal components analysis and partial least squares regression models. Raman technique was able to identify chemical changes resulting from the heating of lubricant oils and to correlate these changes with the heating time, thus becoming a technique of interest for the preventive maintenance area.
Sample Mass Estimate for the Use of Near-Infrared and Raman Spectroscopy to Monitor Content Uniformity in a Tablet Press Feed Frame of a Drug Product Continuous Manufacturing Process
Authors: Hetrick Evan M. , Shi Zhenqi , Harms Zachary D. , Myers David P.
Published: July 2020

Recently, feed frame-based process analytical technology measurements used to assure product quality during continuous manufacturing processes have received significant attention. These measurements are able to accurately determine uniformity of the powder blend before compression, and in these applications, it is necessary to understand the interrogated sample volume per measurement. This understanding ensures that the blend measurement can be indicative of the uniformity of the final dosage form. A scientifically sound approach is proposed here to estimate sample mass for a continuous manufacturing process that utilizes either near infrared or Raman spectroscopy. A wide range of commercially available probes with varying spot diameters are considered. By comparing near infrared and Raman spectroscopy, an optimal range of probe spot diameters was identified in order to reach an estimated sample mass between 50 and 500 mg for pharmaceutical blends per measurement, which is equivalent to common tablet weight ranges for solid oral dosage forms currently on the market.
State Actor Orchestration for Achieving Workforce Development at Scale: Evidence from Four US States
Authors: Myers Jenna E. , Kellogg Katherine C.
Published: July 2020

Using a 20-month qualitative study of four US states that implemented career pathways spanning from high schools to colleges to employers, the authors illustrate the potential for state government actors to facilitate coordination of workforce development systems across geographies and industries. As a complement to explanations situated in workforce intermediary practices or formal state policies, the authors show that state actors can address barriers to coordination by using state actor orchestration—structuring provisional goal setting and revision, encouraging experimentation, and framing coordination to inspire collective action. This approach involves three types of practices: structural (building statewide governance structures and modifying governance processes), political (providing initial direction and piloting and broadening the set of stakeholders), and cultural (identifying key problems and collective action solutions and building social accountability for new roles). These practices vary according to states’ institutional environments: Where governance is more centralized, state actors gain latitude to guide regional workforce development.
Cross-Linguistic Perceptual Categorization of the Three Corner Vowels: Effects of Listener Language and Talker Age
Authors: Chung Hyunju , Munson Benjamin , Edwards Jan
Published: July 2020

The present study examined the center and size of naïve adult listeners’ vowel perceptual space (VPS) in relation to listener language (LL) and talker age (TA). Adult listeners of three different first languages, American English, Greek, and Korean, categorized and rated the goodness of different vowels produced by 2-year-olds and 5-year-olds and adult speakers of those languages, and speakers of Cantonese and Japanese. The center (i.e., mean first and second formant frequencies (F1 and F2)) and size (i.e., area in the F1/F2 space) of VPSs that were categorized either into /a/, /i/, or /u/ were calculated for each LL and TA group. All center and size calculations were weighted by the goodness rating of each stimulus. The F1 and F2 values of the vowel category (VC) centers differed significantly by LL and TA. These effects were qualitatively different for the three vowel categories: English listeners had different /a/ and /u/ centers than Greek and Korean listeners. The size of VPSs did not differ significantly by LL, but did differ by TA and VCs: Greek and Korean listeners had larger vowel spaces when perceiving vowels produced by 2-year-olds than by 5-year-olds or adults, and English listeners had larger vowel spaces for /a/ than /i/ or /u/. Findings indicate that vowel perceptual categories of listeners varied by the nature of their native vowel system, and were sensitive to TA.
Sedentarism and chronic disease risk in COVID 19 lockdown – a scoping review
Authors: Chandrasekaran Baskaran , Ganesan Thiru Balaji
Published: July 2020

Background & Aims

Though viewed as a critical measure to prevent the spread of the virus, a prolonged homestay may result in unfavourable sedentary behaviour and chronic disease risk. This systematic review focuses on sedentary behaviour resulting from this quarantine period which may elevate the cardiovascular disease risk, obesity, hypertension, cancer and mental health illness.

Methods

Evidence of breaking sedentary behaviour and global recommendations were investigated. Potential unanswered questions regarding sedentary behaviour and physical activity during lockdown were explored.

Results

Five systematic reviews and six prospective trials explored the effect of sedentarism affecting chronic disease through potential pathophysiological mechanisms. Sedentary behaviour especially prolonged sitting is found to be a pleiotropic risk factor with altered energy expenditure, adipogenic signalling, immunomodulation, autonomic stability and hormonal dysregulation perpetuating underlying chronic diseases such as obesity, cardiovascular disease, cancer and mental health disorders.

Conclusion

Breaking sitting and physical activity are found to reverse the adverse effects associated with excessive sitting during the lockdown.
Mechanical and thermal behavior analysis of wood–polypropylene composites
Authors: Wang Wei , Liu Liu , Ding Ning , Zhang Ruiyun , Yu Jianyong
Published: July 2020

Bio-based materials have attracted great attention due to their good mechanical properties, biodegradability, low cost, and easy processing, especially abundant resources. In this work, polypropylene (PP) composites reinforced with 15, 30 and 45 wt% wood powder (WP) were prepared by injection molding and their thermal, mechanical, and dynamic mechanical properties were characterized. It was found that the strength and modulus of the composite materials in the tensile and bending tests significantly increased, but the impact strength decreased. The dynamic mechanical test also showed that the storage modulus increased with the increase of WP content. WP endowed the composite material with rigidity and strength, but it was not good for toughness. Besides, the addition of WP did not change the crystal structure of the composites, while the degree of crystallinity decreased. WP-filled PP composites with stable mechanical and thermal properties have great potential to replace traditional glass fiber-reinforced composites in many fields such as construction, sports equipment, and the automotive industry.