bluuebunny/crossref_metadata_2025 huggingface dataset:
Reversible HuR‐microRNA binding controls extracellular export of miR‐122 and augments stress response
Authors: Mukherjee Kamalika , Ghoshal Bartika , Ghosh Souvik , Chakrabarty Yogaditya , Shwetha Shivaprasad , Das Saumitra , Bhattacharyya Suvendra N
Published: July 2016

microRNAs (miRNAs), the tiny but stable regulatory RNAs in metazoan cells, can undergo selective turnover in presence of specific internal and external cues to control cellular response against the changing environment. We have observed reduction in cellular miR‐122 content, due to their accelerated extracellular export in human hepatic cells starved for small metabolites including amino acids. In this context, a new role of human ELAV protein HuR has been identified. HuR, a negative regulator of miRNA function, accelerates extracellular vesicle (EV)‐mediated export of miRNAs in human cells. In stressed cells, HuR replaces miRNPs from target messages and is both necessary and sufficient for the extracellular export of corresponding miRNAs. HuR could reversibly bind miRNAs to replace them from Ago2 and subsequently itself gets freed from bound miRNAs upon ubiquitination. The ubiquitinated form of HuR is predominantly associated with multivesicular bodies (MVB) where HuR‐unbound miRNAs also reside. These MVB‐associated pool of miRNAs get exported out via EVs thereby delimiting cellular miR‐122 level during starvation. Therefore, by modulating extracellular export of miR‐122, HuR could control stress response in starved human hepatic cells.
TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
Authors: Xiang Xianyuan , Werner Georg , Bohrmann Bernd , Liesz Arthur , Mazaheri Fargol , Capell Anja , Feederle Regina , Knuesel Irene , Kleinberger Gernot , Haass Christian
Published: July 2016

Immunotherapeutic approaches are currently the most advanced treatments for Alzheimer's disease (AD). Antibodies against amyloid β‐peptide (Aβ) bind to amyloid plaques and induce their clearance by microglia via Fc receptor‐mediated phagocytosis. Dysfunctions of microglia may play a pivotal role in AD pathogenesis and could result in reduced efficacy of antibody‐mediated Aβ clearance. Recently, heterozygous mutations in the triggering receptor expressed on myeloid cells 2 (TREM2), a microglial gene involved in phagocytosis, were genetically linked to late onset AD. Loss of TREM2 reduces the ability of microglia to engulf Aβ. We have now investigated whether loss of TREM2 affects the efficacy of immunotherapeutic approaches. We show that anti‐Aβ antibodies stimulate Aβ uptake and amyloid plaque clearance in a dose‐dependent manner in the presence or absence of TREM2. However, TREM2‐deficient N9 microglial cell lines, macrophages as well as primary microglia showed significantly reduced uptake of antibody‐bound Aβ and as a consequence reduced clearance of amyloid plaques. Titration experiments revealed that reduced efficacy of amyloid plaque clearance by Trem2 knockout cells can be compensated by elevating the concentration of therapeutic antibodies.
Das Anna-Offizium des Anna Hannsen Schuman-Kodex
Authors: Ferenczi Ilona
Published: July 2016

Only two of the five polyphonic settings of St Anne’s liturgy in the 16th-century Vesperale Anna Hannsen Schuman at the Slovenský Národný Archív in Bratislava are correctly texted. This paper shows how the rhymed responsory Iesu Christe nepos cuius tu could be identified and the texts of the rhymed antiphons O beata Christi ava and Annae sanctae celebremus complemented by consulting a plainchant source from Kirnberg an der Mank in lower Austria.
Beyond the gradual. An analysis of the recited layers of mass propers and the impact of Regensburg on the early Hungarian liturgy
Authors: Horváth Balázs , Földváry Miklós István
Published: July 2016

This study is intended to introduce a pioneering project called Missalia that should serve to enable the analysis and comparison of the Mass proper as a whole, including not only the chanted parts in the strict sense, but also the so-called euchological material, and the corpus of lessons. Given that they belong to the same system, their analysis is indispensable for the interpretation of musical sources, because the layer of the Gradual in its entirety is far less variable than that of the Sacramentary or the Lectionary. Some new principles and methods are proposed in order to describe and classify the Mass proper of medieval liturgical uses, pre-eminently the necessity of a Europe-wide sampling and the importance of early printed material. As a case study, a recent discovery is presented which demonstrates a close and exclusive link between the euchological layers of the late printed Missals of Regensburg and Zagreb. This relationship can be traced back to, and becomes even more obvious in the early 13th century, and a conclusion can be drawn that it originated in the first decades of the 11th century. In this period, and in this period only, is it feasible to suppose that Regensburg exerted a strong influence on the composition of the early Hungarian Sacramentary.
From Easter to St Catherine of Alexandria. The metamorphosis of a sequence
Authors: Kovács Andrea
Published: July 2016

Manuscripts and printed editions of Hungarian provenance contain 288 sequences, out of which 237 have their own music. Particular dioceses and ecclesiastical institutions could decide freely which item they would sing on a given feast. The Ascension sequence Sursum sonet laudis melos, besides being present in the Futaki Gradual, is found only in three manuscripts of Zagreb provenance and in the missal of that diocese printed in 1511. The item is a shortened version in seven verses of a longer, eleven-verse original, written before 1305 by an unknown author and occurring very rarely in sources outside Hungary. In its present shortened form, it is only preserved in the liturgical books of the Hungarian use. The surviving sources show that this variant of the text is the result of a deliberate recrafting that occurred in Zagreb in the first part of the 14th century.
Candor est lucis aeternae: the “Transfiguration” of a new feast and of an Alleluia
Authors: Kiss Gábor
Published: July 2016

The introduction of new feasts was regularly accompanied by a kind of rearrangement of the liturgical material. In the beginning Transfiguratio Domini was not obligatory feast, but was introduced gradually in more and more churches from the 10th century on. During the greater part of its history it had no special Proper for the mass, but different chants were drawn from the masses of traditional feasts, like Christmas, Epiphany, the Easter season and even the Holy Trinity. In the sources that include at all a mass for Transfiguratio we see different sets of Proper chants, borrowed from different feasts. The status of the feast changed when pope Callixtus III extended the feast to the Universal Church in memory of the victory gained by the Hungarians over the Turks. After that a new Proper was compiled, which, however, was slowly adopted by the different dioceses. It is questionable whether new melodies were also composed or the texts were sung to existing melodies instead. In Hungary the feast understandably gained special importance and apparently there was a need for Proper melodies. Since, however, there were no ordered melodies (or they were not at hand), every scriptor had to compose or find their own version. The paper demonstrates a great variety of solutions through the different melodies set to the Alleluia text Candor est lucis.
Influence of study in hee on ubiquity and strength of students’ computer gambling
Authors: Kudryavtsev M.D. , Kramida I.E. , Kuzmin V.A. , Iermakov S.S. , Cieslicka Miroslawa , Stankiewicz Blazej
Published: July 2016

Purpose: to clear up effectiveness of learning-education process for counteraction of students’ harmful passion to computer games’ ubiquity. Material: 1st - 3rd year students (main health group) were the objects of the research. In total they were 952 boys and 523 girls. In 1st year students’ academic groups testing was carried out ant the beginning of academic year (October); in academic groups of 1st-3rd year students the testing was at the end of academic year (May). Results: it was found that among 1st year boy students ubiquity of computer gaming as well as time losses, connected with it are higher than among girl students. Educational process is not sufficiently effective in struggle against computer gaming. For girls, this passion is not dangerous in general. In the course of study at HEE, the strength of this passion reduces independent on sex. Conclusions: for increase of educational process’s effectiveness and improvement of students’ life quality it is necessary to consider personal features of boy students as well as to organize health related measures with the help of health related physical culture means.
Integrative assessment of kick boxers’ brain blood circulation and bio-electrical activity in conditions of correction technologies’ application
Authors: Romanov Y.N. , Isaev A.P. , Shevtsov A.V. , Romanova L.A. , Cieslicka M. , Muszkieta R.
Published: July 2016

Purpose: to scientifically substantiate the role of para-vertebral impacts on blood circulation and bio-electrical activity of kick boxers’ cortex. Material: in the research participated kick boxers (main group, n=62) and university students (control group, n=25) of 18-23 years’ age. Assessment of para-vertebral impacts with device Armos and classic massage was fulfilled with the help of the following methodic: trans-cranial dopplerography of head main arteries and cortex EEG of the tested. Results: it was found that with the help of para-vertebral impacts by device Armos linear velocity of cerebral blood flow reduces to normal limits and in- and inter-hemispheres’ interaction strength increases. Conclusions: para-vertebral impacts by device Armos activate integrative processes and inter-hemispheres’ interactions of different cortex areas of kick boxers. It can witness about better formation of functional systems, ensuring sports efficiency.
PERSONALITY ORIENTED SYSTEM OF STRENGTHENING OF STUDENTS’ PHYSICAL, PSYCHIC AND SOCIAL-MORAL HEALTH
Authors: Kudryavtsev M.D. , Kopylov Yu.A. , Kuzmin V.A. , Ionova O.M. , Yermakova T.S.
Published: July 2016

Purpose: to work out content of individualized trainings, permitting to correct deviations in different aspects of physical, psychic and social-moral health of higher educational establishments’ students. Material: in experiment 105 boy students of 20-24 years’ age participated. All students gave conscious consent to participate in experiment. The trainings were practiced 4 times a week, 45 minutes each. Results: it is interesting that change of different personality’s features is rather long process, which in some aspects resist to changes. We showed approaches to training vitally important skills and abilities, required for adaptation to modern social cultural medium; to the simplest techniques of organization of independent health related physical culture trainings; to means of health strengthening, formation of knowledge on health related physical culture. We developed personality-oriented system of formation of psychic and social-moral health. Conclusions: the worked out approach permits to achieve real positive psychic and socially important qualities of student’s personality during one academic year.
IMPROVING THE POSITIONING ACCURACY OF TRAIN ON THE APPROACH SECTION TO THE RAILWAY CROSSING
Authors: Havryliuk V. I. , Voznyak O. M. , Meleshko V. V.
Published: July 2016

Purpose. In the paper it is necessary to analyze possibility of improving the positioning accuracy of train on the approach section to crossing for traffic safety control at railway crossings. Methodology. Researches were performed using developed mathematical model, describing dependence of the input impedance of the coded and audio frequency track circuits on a train coordinate at various values of ballast isolation resistances and for all usable frequencies. Findings. The paper presents the developed mathematical model, describing dependence of the input impedance of the coded and audio-frequency track circuits on the train coordinate at various values of ballast isolation resistances and for all frequencies used in track circuits. The relative error determination of train coordinate by input impedance caused by variation of the ballast isolation resistance for the coded track circuits was investigated. The values of relative error determination of train coordinate can achieve up to 40-50 % and these facts do not allow using this method directly for coded track circuits. For short audio frequency track circuits on frequencies of continuous cab signaling (25, 50 Hz) the relative error does not exceed acceptable values, this allow using the examined method for determination of train location on the approach section to railway crossing. Originality. The developed mathematical model allowed determination of the error dependence of train coordinate by using input impedance of the track circuit for coded and audio-frequency track circuits at various frequencies of the signal current and at different ballast isolation resistances. Practical value. The authors proposethe method for train location determination on approach section to the crossing, equipped with audio-frequency track circuits, which is a combination of discrete and continuous monitoring of the train location.
METHODOLOGICAL FUNDAMENTALS OF DETERMINATION OF UNPOWERED ROLLING STOCK MAINTENANCE CHARACTERISTICS
Authors: Muradian L. A. , Shaposhnyk V. Yu. , Mischenko A. A.
Published: July 2016

Purpose. The paper involves: 1) confirmation of the technical characteristics of cars and their modifications, as well as indicators of unfailing work probability during the time between overhauls or service hours; 2) improving the methodological approaches to assess the maintenance characteristics of new and modernized equipment of rail transport on the example of not self-propelled rolling stock, namely, railway freight cars; 3) solution of scientific and applied problems in assessment the maintenance characteristics of the new and modernized railway equipment. Methodology. The basic methodological approaches to the assessment of the maintenance characteristics on the example of not self-propelled rolling stock, namely, railway freight cars were considered. The analysis of the reliability of the car, which is considered as a complex mechanical system, where all system elements are connected in series, wherein each element includes m is serially connected parts. The failure of each part of the calculation will result in refusal of the car. Thus, the car is a system without redundancy. Findings. The evaluation technic of the maintenance characteristics of freight cars in controlled operation with taking into account the features of the new generation of cars was improved. Specified: the duration of the tests, the frequency of inspection of the control group of cars controlled by the parameters of the car, the reasons for the early termination of controlled operation. Identified failures in the process of controlled operation are divided according to their nature. Originality. The authors proposed a method of assessing the maintenance characteristics of railway equipment in trial operation as an example of a new generation of freight cars. Practical value. The results allow assessing the maintenance characteristics of new and modernized rail transport equipment during the maintenance test.
STRUCTURE FORMATION IN FOUNDATION SLAB CONCRETE
Authors: Kovalenko V. V. , Zayats Yu. L. , Pshinko P. O. , Kovalenko S. V.
Published: July 2016

Purpose. The work involves identifying the dependence of structural and mechanical properties of the concrete on the composition of used modifier additives, the nature of changes of structural and mechanical properties depending on the period of concrete hardening of test and modified samples. Methodology. The applied microstructural, fractographic, microprobe analyses and physico-mechanical tests revealed the required dependencies. Findings. The microstructure of the cement stone under equal conditions of concrete mix selection depends on the composition of used raw materials and production technology. This paper investigates the structural changes in the setting time of hard mixture concrete and effect of component parts of the complex modifier additive PLKP (produced by «Logia», Dnepropetrovsk) on morphology, dispersion and chemical composition of the cement stone, as well as the mechanical characteristics of concrete for the foundation slab. The study of the structural and physical-mechanical characteristics of the test samples and modified concrete at various hardening stages showed that the use Ukrainian hyper-plasticizer PLKP contributes to the formation of nano-structured concrete. The addition of hardening accelerators to the super-plasticizer additive reduces the diameter of crystal whiskers, increases the structural homogeneity and stability and improves the complex of the concrete mechanical characteristics. Application of new PLKP polycarboxylate additives in the production of concrete mixtures for the foundation slab allows eliminating the steaming from the foundation slab production technology. The absence of salt component in the additive improves the concrete durability. Originality. The paper showed that modification of the concrete with complex additive PLKP facilitates the formation of the most homogeneous structure of cement stone, which consists of compact crystals surrounded by fibrous crystals that are tightly intertwined in the pore space. This structure contributes to the maximum characteristics of the concrete compressive strength. Herewith the steaming by traditional technology helps to increase the size of the primary ettringite crystals having a tendency to restructure during the operation of concrete products at temperatures of around 200°C. Practical value. Adjustment of foundation slab production parameters, namely – steaming temperature reduction or elimination of this operation from the concrete sleeper production cycle, using PLKP additives, can improve the structural homogeneity and stability, increase the density of the concrete and result in positive effect on its durability.
IMPACT OF MATRIX INVERSION ON THE COMPLEXITY OF THE FINITE ELEMENT METHOD
Authors: Sybis M. , Smoczkiewicz-Wojciechowska A. , Szymczak-Graczyk A.
Published: July 2016

Purpose. The development of a wide construction market and a desire to design innovative architectural building constructions has resulted in the need to create complex numerical models of objects having increasingly higher computational complexity. The purpose of this work is to show that choosing a proper method for solving the set of equations can improve the calculation time (reduce the complexity) by a few levels of magnitude. Methodology. The article presents an analysis of the impact of matrix inversion algorithm on the deflection calculation in the beam, using the finite element method (FEM). Based on the literature analysis, common methods of calculating set of equations were determined. From the found solutions the Gaussian elimination, LU and Cholesky decomposition methods have been implemented to determine the effect of the matrix inversion algorithm used for solving the equations set on the number of computational operations performed. In addition, each of the implemented method has been further optimized thereby reducing the number of necessary arithmetic operations. Findings. These optimizations have been performed on the use of certain properties of the matrix, such as symmetry or significant number of zero elements in the matrix. The results of the analysis are presented for the division of the beam to 5, 50, 100 and 200 nodes, for which the deflection has been calculated. Originality. The main achievement of this work is that it shows the impact of the used methodology on the complexity of solving the problem (or equivalently, time needed to obtain results). Practical value. The difference between the best (the less complex) and the worst (the most complex) is in the row of few orders of magnitude. This result shows that choosing wrong methodology may enlarge time needed to perform calculation significantly.
Embates acerca da ideia de justiça social em relação a conflitos sociais e desigualdades
Authors: Pizzio Alex
Published: July 2016

Resumo A justiça social é um tema controverso, de amplo debate no âmbito das ciências sociais. Seu caráter impreciso decorre das diversas abordagens encontradas acerca do tema, que ora a concebem como derivada de um procedimento institucional vinculado à justiça formal e de base material, ora a concebem como procedente da conduta individual vinculada à ética e à moral. Nessa perspectiva, a temática demanda um conjunto de questionamentos. Quando se fala de justiça social, quais questões, exatamente, estão envolvidas? Quais elementos a constituem? Quando se pode dizer que uma pessoa ou instituição é justa ou injusta? Em outras palavras, quando se sabe ou se pode afirmar que as ocorrências cotidianas refletem arranjos sociais justos? Essas e outras indagações são de extrema relevância quando se evolui no debate acerca da gestão e da implementação de políticas públicas que têm por meta alcançar um patamar elevado de justiça social. O objetivo deste artigo é contribuir para o enriquecimento desse debate, incluindo elementos que consideramos importantes para o avanço das políticas públicas em sociedades como a brasileira.
Combates pela educação operária: aspectos da reação católica à criação de Escolas Modernas no Brasil (1900-1920)
Authors: Bilhão Isabel
Published: July 2016

Resumo As propostas pedagógicas e os dados biográficos de Francisco Ferrer y Guardia já foram bastante estudadas no contexto acadêmico brasileiro. No entanto, ainda carecem de maior investigação os argumentos e as estratégias utilizados pelos grupos opositores às suas concepções educacionais, especialmente os provenientes de membros da Igreja. Este artigo objetiva analisar alguns aspectos da reação católica à criação de Escolas Modernas no país nas primeiras décadas do século XX. Tal discussão embasa-se empiricamente em um encarte especial da Revista Vozes de Petrópolis, publicado em 1913. Pretende-se ampliar a compreensão dos embates em torno da educação operária no período inicial da República, refletindo especialmente sobre as estratégias argumentativas de religiosos que se propõem a combater a difusão da educação racionalista entre os trabalhadores.
Las bases curriculares 2013: los desafíos actuales para la formación inicial y aprendizaje histórico de profesores de historia en Chile
Authors: Vásquez Leyton Gabriela
Published: July 2016

Resumen El artículo que se presenta tiene por finalidad revisar las bases curriculares 2013 propuestas para la asignatura de historia, geografía y ciencias sociales de 7º básico a 2º medio, con el objetivo de definir los retos para la formación inicial de profesores de historia en Chile y, por ende, estipular posibles estrategias de enseñanza tanto para los formadores de profesores como para los investigadores en didáctica de la historia y de las ciencias sociales. Estos desafíos se relacionan, principalmente, con incluir en el proceso de aprender a enseñar el desarrollo del pensamiento histórico y el desarrollo de las habilidades cognitivas que permitan la comprensión profunda de los procesos históricos tales como pensamiento temporal y espacial, análisis y trabajo con fuentes, pensamiento crítico y comunicación.
As possibilidades investigativas da aprendizagem histórica de jovens estudantes a partir das histórias em quadrinhos
Authors: Fronza Marcelo
Published: July 2016

Resumo O objetivo deste estudo é investigar como a verdade histórica e a intersubjetividade organizam a forma como os jovens tomam o conhecimento para si. A investigação é estruturada nas relações entre a cultura jovem, as histórias em quadrinhos e a cultura histórica de uma sociedade (RÜSEN, 2009). Analisam-se possibilidades investigativas existentes na relação entre as histórias em quadrinhos e a aprendizagem histórica de jovens estudantes. Abordam-se os tipos de investigações sobre como as narrativas históricas gráficas entraram na cultura escolar: 1) os quadrinhos ligados ao mercado das histórias em quadrinhos ficcionais com temas históricos; 2) os livros didáticos; 3) as histórias em quadrinhos didáticas na forma de paradidáticos; 4) as histórias em quadrinhos produzidas pelos próprios estudantes; e 5) as narrativas gráficas autobiográficas.
A eficiência do comportamento tático e a data de nascimento influenciam a performance tática de jogadores de futebol da categoria sub-11?
Authors: MACHADO Guilherme Figueiredo , TEOLDO Israel
Published: July 2016

Resumo O objetivo do estudo é verificar se a eficiência do comportamento tático e os quartis de nascimento influenciam a performance tática de jogadores de futebol da categoria sub-11. A amostra foi composta por 102 jogadores de futebol da categoria sub-11, participantes de campeonatos regionais. O instrumento utilizado para avaliar a performance tática foi o FUT-SAT. Utilizou-se o teste de Regressão Logística Multinomial para verificar associação entre as variáveis, a partir da divisão da eficiência do comportamento e da performance tática em tercis (p ≤ 0,05). Verificou-se associações positivas entre a eficiência do comportamento tático e os índices de performance tática para o princípio de unidade defensiva. Encontrou-se associações positivas entre data de nascimento e o índice de performance tática em jogadores nascidos no último quartil do ano. Conclui-se que a performance tática sofreu influência da data de nascimento e da eficiência do comportamento tático.
Análise do discurso de indivíduos afásicos fluentes e com leve dificuldade de compreensão oral
Authors: Medeiros Juliana Silveira Ferreira de , Rissoni Thamara Chrystina de Andrade , Santana Andréa Siqueira Kokanj , Ishigaki Ellen Cristina Siqueira Soares
Published: July 2016

RESUMO: Objetivo: analisar os discursos narrativo, descritivo, conversacional e procedural de indivíduos afásicos fluentes e compará-los com indivíduos saudáveis. Métodos: foram selecionados, por meio de amostragem sistemática, 22 indivíduos afásicos fluentes com queixas de dificuldade discursiva e que apresentam alteração de linguagem pós-acometimento em Sistema Nervoso Central decorrente de Acidente Vascular Encefálico, que estão ou já estiveram em tratamento na instituição de origem. Estes foram pareados a indivíduos saudáveis de mesma idade e escolaridade e ambos os grupos foram submetidos a um protocolo de tarefas discursivas orais para avaliação dos discursos narrativo, explicativo, conversacional e procedural. Resultados: houve diferenças estatisticamente significantes na maioria das variáveis investigadas em todos os tipos de discursos tanto na análise quantitativa quanto na qualitativa. Conclusão: indivíduos afásicos apresentaram maior facilidade no discurso narrativo e maior dificuldade nos demais discursos, porém comparando-os aos indivíduos saudáveis apresentaram maior dificuldade em todos os gêneros discursivos orais.
From essence to Lebenswelt as a method in phenomenological psychopathology
Authors: MOREIRA Virginia
Published: July 2016

Abstract The use of different phenomenological philosophies as a methodological inspiration in psychopathology certainly leads to methodological implications that must be taken into account. Karl Jaspers, who was inspired by Husserl's transcendental phenomenology, sought the essence so as to reach the generality of the lived psychopathology, thereby giving birth to general psychopathology. This paper advocates for the ambiguous phenomenological method, inspired by Merleau-Ponty's philosophy of ambiguity, as a means to describe the lived psychopathology as Lebenswelt at the intersection of singular and universal in the reversibility of the chiasm. By leaving aside the essence and turning to the Lebenswelt, the ambiguous phenomenological method assumes that the lived pathology is produced in the intersection between the world and man, with culture as a constitutive dimension.
Poaceae em uma planície de inundação no Brasil: listagem florística e novas ocorrências
Authors: Kawakita Kazue , Rodrigues Rodrigo S. , Filgueiras Tarciso S.
Published: July 2016

RESUMO O presente estudo objetiva caracterizar as Poaceae da Planície de Inundação do Alto Rio Paraná (PIAP) e seu entorno, localizada a 22º38'-22º57'S e 53º05'-53º36'O, entre os Estados do Paraná e Mato Grosso do Sul. Foram analisadas 916 exsicatas provenientes de coleções de herbário ou obtidas em campo entre 1988 e 2015. Como resultado, registra-se a ocorrência de 50 gêneros e 94 espécies, sendo 68,08% nativas e 31,92% naturalizadas. Panicoideae é a maior subfamília, com 68,08% das espécies, seguida de Chloridoideae (12,24%) e Bambusoideae (11,22%), ao passo que Oryzoideae, Arundinoideae e Pooideae representam menos de 10% das espécies. A maioria das espécies é perene (80,85%), porte herbáceo (77,66%) ou arbustivo (12,77%), terrestre (42,55%) ou palustre (37,24%). Sete espécies representam novos registros para o Mato Grosso do Sul e sete para o Paraná.
Celebridade e política do nome próprio: a historicidade do renome em Machado de Assis
Authors: Campos Raquel
Published: July 2016

RESUMO Respondendo ao convite inscrito no título de "Um homem célebre", procura-se discutir o conto machadiano à luz do problema da historicidade da celebridade. Longe de ter sempre existido ou de ser um fenômeno atualíssimo, a celebridade - mostrou Antoine Lilti - é uma nova forma do renome, nascida na segunda metade do século XVIII em um contexto de crise das sociedades aristocráticas e de abertura do espaço público. Tal perspectiva conduz a aproximar a história do maestro Pestana não dos demais contos de temática musical, mas de "Fulano", narrativa sobre um autêntico perito na arte da autopromoção, praticante de uma verdadeira "política do nome próprio". Por meio da análise desses dois contos e da comparação de Pestana e Fulano com algumas das personagens machadianas obcecadas com a glória - Brás Cubas, o pai de Janjão ("Teoria do medalhão") e Santos (Esaú e Jacó) - busca-se demonstrar a existência, em Machado de Assis, de uma reflexão sobre a historicidade do renome.
Impact on Patient Management of [18F]-Fluorodeoxyglucose-Positron Emission Tomography (PET) Used for Cancer Diagnosis: Analysis of Data From the National Oncologic PET Registry
Authors: Subramaniam Rathan M. , Shields Anthony F. , Sachedina Archana , Hanna Lucy , Duan Fenghai , Siegel Barry A. , Hillner Bruce E.
Published: July 2016

Introduction.

We assessed the impact of [18F]-fluorodeoxyglucose (FDG)-positron emission tomography (PET) on intended management of patients in the National Oncologic PET Registry (NOPR) for three different diagnostic indications: (a) determining whether a suspicious lesion is cancer (Dx), (b) detecting an unknown primary tumor site when there is confirmed or strongly suspected metastatic disease (cancer of unknown primary origin [CUP]), and (c) detecting a primary tumor site when there is a presumed paraneoplastic syndrome (PNS).

Methods.

We reviewed a sample of randomly selected reports of NOPR subjects who underwent PET for Dx and CUP and all reports for PNS to find subjects for analysis. For these studies, we evaluated the impact of PET on referring physicians’ intended management, based on their management plans reported before and after PET.

Results.

Intended management was changed more frequently in the CUP group (43.1%) than in the Dx (23.9%) and PNS (25.4%) groups (CUP vs. Dx, p < .0001; PNS vs. Dx, p < .0001; CUP vs. PNS, p < .0002). Referring physicians reported that, in light of PET results, they were able to avoid further testing in approximately three-fourths of patients (71.8%–74.6%). At the time when the post-PET forms were completed, biopsies of suspicious sites had been performed in 21.2%, 32.4%, and 23.2%, respectively, of Dx, CUP, and PNS cases.

Conclusion.

Our analysis of NOPR data shows that PET appears to have a substantial impact on intended management when used for three common diagnostic indications.
Gastroenteropancreatic Well-Differentiated Grade 3 Neuroendocrine Tumors: Review and Position Statement
Authors: Coriat Romain , Walter Thomas , Terris Benoît , Couvelard Anne , Ruszniewski Philippe
Published: July 2016

In 2010, the World Health Organization (WHO) classification of neuroendocrine neoplasms was reviewed and validated the crucial role of the proliferative rate. According to the WHO classification 2010, gastroenteropancreatic neuroendocrine neoplasms are classified as well-differentiated neuroendocrine tumors (NETs) of grade 1 or 2 in up to 84%, or poorly differentiated neuroendocrine carcinomas in 6%–8%. Neuroendocrine carcinomas are of grade G. Recently, a proportion of neuroendocrine tumors presenting a number of mitoses or a Ki-67 index higher than 20% and a well-differentiated morphology have been identified, calling for a new category, well-differentiated grade 3 NET (NET G-3). Studies that have reported the characteristics of neuroendocrine neoplasms have identified more well-differentiated NET G-3 than neuroendocrine carcinomas. The main localizations of NET G-3 are the pancreas, stomach, and colon. Treatment for NET G-3 is not standardized and is balanced between G-1/2 neuroendocrine tumor and neuroendocrine carcinoma treatments. In nonmetastatic neuroendocrine tumors, the European and American guidelines recommended a surgical resection for localized neuroendocrine neoplasm, irrespective of the tumor grading. In NET G-3, chemotherapy is the benchmark if the main treatment goal is reduction of the tumor mass, particularly if it would allow a secondary surgery. In the present work, we review the epidemiology and make recommendations for the management of NET G-3.
Sarcomas Associated With Genetic Cancer Predisposition Syndromes: A Review
Authors: Farid Mohamad , Ngeow Joanne
Published: July 2016

Sarcomas are rare mesenchymal malignancies that demonstrate great clinical and biological heterogeneity. A variety of sarcomas develop in the context of well-defined heritable cancer predisposition syndromes, associations that are often overlooked, given the rarity and diversity of sarcomas and the equivalent relative infrequency of cancer genetic syndromes. This review describes in detail selected heritable cancer predisposition syndromes that are known to be associated with sarcomas. Beyond the molecular and clinical features that define each syndrome, disparities in clinical presentation, natural history, and treatment of syndrome-associated compared with otherwise histologically identical sporadic sarcomas will be described. The clinical approach to selected sarcoma subsets with a view to identifying possible associations with these syndromes will then be described. Although the treatment of the majority of sarcomas will not differ significantly between sporadic cases and those associated with predisposition syndromes, knowledge of features such as unique anatomic sites of affliction or excess toxicities with particular cytotoxic therapies can facilitate alterations in therapeutic strategies to maximize efficacy and minimize toxicity. In addition, recognition of cancer genetic predisposition syndrome will allow patients and their relatives to undertake appropriate genetic counseling and testing, as well as screening, surveillance, and interventional measures, as needed. Situating sarcomas within the genetic endowment of particular patients—specifically that which confers a higher risk of malignancy—will enable clinicians to better manage the patient as a whole, complementing the great efforts currently routinely undertaken to genomically characterize somatic tumor changes with a view to achieving the dream of personalized medicine.
Cancer Control in Central and Eastern Europe
Authors: La Vecchia Carlo , Conte Pierfranco
Published: July 2016

In Central and Western Europe, cancer mortality is declining at slower rates as compared with rates in the rest of the world. More than a generation has now passed since the end of nonmarket economies in Central and Eastern Europe. It is time for this area of the continent to close the gap in cancer incidence and mortality rates between it and Western Europe and other high-income areas of the world.
Pragmatic Trials in Maintenance Dialysis: Perspectives from the Kidney Health Initiative
Authors: Dember Laura M. , Archdeacon Patrick , Krishnan Mahesh , Lacson Eduardo , Ling Shari M. , Roy-Chaudhury Prabir , Smith Kimberly A. , Flessner Michael F.
Published: July 2016

Pragmatic clinical trials are conducted under the real-world conditions of clinical care delivery. As a result, these trials yield findings that are highly generalizable to the nonresearch setting, identify interventions that are readily translatable into clinical practice, and cost less than trials that require extensive research infrastructures. Maintenance dialysis is a setting especially well suited for pragmatic trials because of inherently frequent and predictable patient encounters, highly granular and uniform data collection, use of electronic data systems, and delivery of care by a small number of provider organizations to approximately 90% of patients nationally. Recognizing the potential for pragmatic trials to generate much needed evidence to guide the care of patients receiving maintenance dialysis, the Kidney Health Initiative assembled a group of individuals with relevant expertise from academia, industry, and government to provide the nephrology community with information about the design and conduct of such trials, with a specific focus on the dialysis setting. Here, we review this information, and where applicable, use experience from the ongoing Time to Reduce Mortality in End Stage Renal Disease Trial, a large cluster-randomized, pragmatic trial evaluating hemodialysis session duration, to illustrate challenges and solutions to operational, ethical, and regulatory issues.
Bank Complexity: Is Size Everything?
Authors: Oldfather Jeremy , Gissler Stefan , Ruffino Doriana
Published: July 2016

Can we measure the complexity of large banks by comparing their balance sheets?
Níveis de atividade física em dois modelos de aulas de Educação Física
Authors: Lemes Vanilson Batista , Gaya Adroaldo , Moreira Rodrigo , Gaya Anelise
Published: July 2016

Objetivo: comparar os níveis de atividade física de escolares, através de dois modelos de aulas de Educação Física no ensino fundamental. Método: o presente estudo se caracteriza como uma pesquisa avaliativa somativa. Os sujeitos da pesquisa foram escolhidos de forma conveniente, totalizando 15 casos, sendo 7 do sexo masculino. Os instrumentos utilizados para a coleta de dados referentes à atividade física foram pedômetros. A Educação Física foi observada em duas aulas e descrita no que se refere às atividades desenvolvidas. Resultados: a aula fundamentada na aprendizagem das habilidades motoras do handebol e do basquete, em conjunto com gestos utilizados no voleibol, comparativamente a aula dois, fundamentada nas atividades de circuito com habilidades motoras dos esportes citados e grande jogo de handebol adaptado, apresentou um número médio de passos inferior (aula 1: 32,72±7,84 vs. aula 2: 58,05±13,34; p
Causas e implicações da imagem corporal em adolescentes: um estudo de revisão
Authors: Uchôa Francisco Nataniel Macêdo , Lustosa Romário Pinheiro , Rocha Maria Tatiana De Lima , Daniele Thiago Medeiros da Costa , Aranha Ágata Cristina Marques
Published: July 2016

A preocupação com a aparência física é algo indispensável ao ser humano e é cada vez mais preponderante em nossa sociedade que, através de diversos meios, evidencia corpos esteticamente perfeitos. No decorrer dos últimos anos, houve uma crescente preocupação com a imagem corporal (IC). Como a maioria da população não se encaixa nos padrões que a mídia impõe, podem surgir distorções da IC. A imagem corporal configura-se como a figura mental que temos do nosso corpo, juntamente de como sentimos, de como queremos que ele seja. Objetivo: O objetivo da pesquisa foi realizar uma revisão de literatura sobre imagem corporal, identificando suas causas e implicações nos adolescentes. Método: A pesquisa realizada caracteriza-se como uma revisão de literatura. A busca dos artigos ocorreu nos meses de setembro a novembro de 2015, nas bases de dados eletrônicas Scielo, Medline, Pubmed, Scopus e Lilacs. Resultados: Foram encontrados 56 artigos, conforme os requisitos da pesquisa; foram utilizados 23 artigos para revisão. Considerações finais: A influência das relações sociais, na transformação da IC, exerce um papel fundamental na atual sociedade. O fator simbólico do corpo tornou-se fator fundamental de inserção social, especialmente entre os jovens.
Perfil profissional de nutricionistas egressos da Universidade de Santa Cruz do Sul
Authors: Feix Monique , Poll Fabiana Assmann
Published: July 2016

Objetivo: avaliar o perfil profissional dos nutricionistas egressos da Universidade de Santa Cruz do Sul, no período de 2002 a 2014, buscando identificar as áreas de atuação, cidades de atuação, a satisfação profissional e os índices de realização de pós-graduação, bem como observar a filiação aos órgãos da classe. Método: estudo de delineamento transversal, utilizou a aplicação de um questionário estruturado de auto resposta, remetido aos 323 egressos, via endereços eletrônicos. Para a análise dos dados foi utilizado o programa Microsoft Excel. Resultados e Considerações finais: dos 107 egressos de nutrição que aderiram à pesquisa, 83,1% (n=89) exercem a profissão, sendo a área de atuação que mais emprega a alimentação coletiva, 50,6% (n=45). Os nutricionistas atuam, principalmente, na região do Rio Grande do Sul, sendo a principal cidade Santa Cruz do Sul, 47,2% (n=42). A maioria 65,2% (n=58) informou o desejo de permanecer na área em que estava atuando, sendo a nutrição clínica, àquela com maior número de satisfeitos. Os egressos estão filiados aos Conselhos Regionais de Nutricionistas e buscam atualização em programas de pós-graduação. Este tipo de estudo possibilita o aprimoramento da formação e satisfação profissional em Nutrição da Universidade.
Efeitos da ginástica abdominal hipopressiva sobre a musculatura pélvica em mulheres incontinentes
Authors: Valente Maiara Guerra , Freire Ariane Bôlla , Real Amanda Albiero , Pozzebon Nathália Mezadri , Braz Melissa Medeiros , Hommerding Patricia Xavier
Published: July 2016

A incontinência urinária é definida pela Sociedade Internacional de Continência como a perda involuntária de urina. É uma condição multifatorial, que acomete ambos os sexos, em diversas idades. O envelhecimento, a multiparidade e cirurgias prévias são alguns dos fatores que levam à disfunção da musculatura perineal. Objetivo: avaliar os efeitos da ginástica abdominal hipopressiva sobre a força dos músculos do assoalho pélvico em um grupo de seis mulheres com incontinência urinária de esforço. Método: as participantes foram submetidas à ficha de avaliação, testes de força perineal e teste de ativação do músculo transverso do abdômen, pré e pós-tratamento. Foram realizadas 10 sessões fisioterapêuticas. Ao final do tratamento, as pacientes foram reavaliadas e os dados foram analisados pela estatística descritiva. Resultados: observou-se melhora na força do assoalho pélvico, bem como melhora na ativação do transverso abdominal. Considerações finais: o protocolo da ginástica abdominal hipopressiva parece ser um método eficiente para auxiliar mulheres com incontinência urinária de esforço, pois aumentou a força perineal e ativou o músculo transverso do abdômen nas participantes deste estudo.
Efeitos da cafeína na performance de exercícios de endurance
Authors: Da Silva Giuliano Roberto , Tavares Marcelo Rodrigo , Terra Gerusa Dias Siqueira Vilela , Neiva Cassiano Merussi , Rodrigues César Augusto Costa , Vilas Boas Yvan Fernandes , Barcelos Tatiana De Araújo
Published: July 2016

Objetivo: verificar os efeitos da cafeína na performance de exercícios de endurance, através do teste de exaustão na bicicleta ergométrica. Método: participaram 50 indivíduos do sexo masculino, submetidos ao teste de exaustão em cicloergômetro após ingestão de 6mg/kg de cafeína (CAF) (n=25; grupo cafeína), e 6mg/kg de placebo (PLA) (n=25; grupo placebo), 40 minutos antes do teste. Os dados foram tratados estatisticamente, submetidos ao teste t de Student (p
Avaliação da frequência de incontinência urinária em jogadoras de voleibol amadoras de Santa Maria-RS
Authors: Frigo Letícia Fernandez , Bordin Daiane Fontana , Romeiro Caio Alexandre Parra
Published: July 2016

As mulheres estão praticando voleibol com vistas a um corpo saudável e buscando melhorar a qualidade de vida e bem estar físico, porém, se não orientadas corretamente, podem desenvolver fraquezas e disfunções pélvicas. Objetivo: este estudo teve como objetivo avaliar a frequência de incontinência urinária em jogadoras amadoras de voleibol de Santa Maria, RS. Método: a amostra foi composta por 23 mulheres praticantes de voleibol, com faixa etária de 23 a 42 anos. Foram realizados encontros em horários previamente agendados com as voluntárias, sendo aplicados os instrumentos de avaliação, a ficha de identificação e o questionário utilizado, a fim de avaliar os sintomas das perdas urinárias e sua história ginecológica. Resultados: sete apresentaram queixa de incontinência urinária; duas relataram perder urina com riso, quatro com tosse, duas com espirro e uma com agachamento, sendo que nove perdem urina em gotas. Das 23 jogadoras cinco apresentam incontinência urinaria leve e quatro moderada. Quanto ao tempo dos sintomas, duas relatam ser há mais de 20 anos, duas há menos de um ano e cinco há seis meses. Considerações finais: os resultados nos mostram fortes indícios para levantar a hipótese de que a Incontinência Urinária em jogadoras de voleibol está relacionada com a atividade e o treinamento de alto impacto, tornando importante a prevenção de tais disfunções para que as atletas não venham a desenvolver patologias no futuro.
Efeitos do método pilates na mobilidade da coluna vertebral na qualidade de vida de idosos: estudo de caso
Authors: Bertoldi Josiane Teresinha , Winter Raquel Aparecida , Fialho Sabrina Pscheidt
Published: July 2016

Objetivo: investigar os efeitos dos exercícios do método Pilates na mobilidade da coluna vertebral, na independência e na qualidade de vida de idosos. Método: foram realizadas anamnese, teste de Schober (TSC) para flexibilidade da região lombossacral; teste de Stibor (TST) para região tóraco-lombar; atividades básicas de vida diária (ABVD´s) pelo Índice de Katz e o questionário WHOQOL-Bref de qualidade de vida (QV). Os critérios de inclusão foram idosos da comunidade em geral, com idade igual ou superior a 60 anos, sendo excluídos os idosos com déficit cognitivo, acamados ou cadeirantes, com infecções, com patologias que restrinjam o movimento da coluna como artrose, artrodese, osteoporose, entre outras com diagnóstico clínico. A amostra foi composta por um idoso, sexo masculino, com 67 anos, submetido a 10 sessões de exercícios selecionados do método Pilates aplicados no solo para nível iniciante, sendo três vezes por semana com duração de 30 minutos. Resultados: os resultados apontaram acréscimo de 4,5cm no TSC e 3,0cm no TST, ABVD´s sem alterações e WHOQOL-Bref com leve evolução. Considerações finais: o método Pilates promove melhora significativa na mobilidade e flexibilidade da coluna vertebral, porém traz poucos efeitos sobre a percepção da qualidade de vida em idosos independentes.