bluuebunny/crossref_metadata_2025 huggingface dataset:
The association between idiopathic pulmonary fibrosis and diabetes mellitus: a clinical retrospective study
Authors: Ji Tong , Chen Ranxun , Zhong Guanning , Lyu Wenting , Xu Qingqing , Jiang Hanyi , Gao Yujuan , Cao Min , Cai Hourong , Dai Jinghong
Published: June 2023

Background
Diabetes mellitus (DM) has been found to be related to lung fibrosis. However, the relationship between DM and idiopathic pulmonary fibrosis (IPF) remains uncertain. In this study, we aimed to determine the prevalence of DM in IPF and whether DM is associated with survival in IPF.
Methods
415 IPF patients were classified as two groups based on whether they were combined with or without DM. The medical records were reviewed and the baseline characteristics and survival times were compared. The adjusted Cox proportional hazards model was used to investigate the risk factors predicting survival in IPF patients and patients combined with IPF and DM, respectively. Then we selected predictors to establish predictive model for mortality.
Results
The prevalence of DM in IPF patients was 25.54%. DM was associated with reduced survival time(P = 0.002). DM (hazard ratio [HR], 1.421; 95% CI, 1.010–1.980; P = 0.039), acute exacerbation (AE)(HR, 2.419; 95% CI, 1.704–3.434; P < 0.001) and antifibrotic drugs (HR, 0.297; 95% CI, 0.199–0.422; P < 0.001) were independent significant factors of mortality in IPF patients. We proposed a prediction model based on DM, AE, antifibrotic drugs to stratify the risk of 1-year mortality of IPF patients. A small internal validation cohort showed the odds of with DAA scores of 0, 1 and 2 were 6.25%, 12.50%, 85.71%, respectively (no patient scored 3). Further, in patients combined with IPF and DM, metformin treatment was associated with prolonged survival time (P = 0.040), and the sequence of diagnoses of IPF and DM (HR, 0.671; 95% CI, 0.363–1.240; P = 0.203) did not affect the mortality of patients combined with IPF and DM.
Conlusions
Our retrospective study showed that DM was prevalent and were an independent risk factor for predicting mortality in IPF patients. And we established a predictive model for the risk of 1-year mortality of IPF patients which need further validations.
XRD, SEM, Thermal and Optical Properties of TeO 2 -ZnCl 2 -Nb 2 O 5 -TiO 2 Based Glass System According to Preparation Temperatures
Authors: Kabalci Idris , Abdullah Taufiq
Published: June 2023

The objective of this study is to design a unique glass network composed of TeO2-ZnCl2-Nb2O5-TiO2 to investigate the optical, thermal and microstructural properties. In this experiment, the proposed glass network was produced using melt quenching method. The optical properties and optical band-gap was derived from the UV-VIS spectrophotometry experiment. Following the optical properties, the thermal and microstructural properties including the melting point and the transition phase was calculated through Differential Thermal Analysis (DTA/DSC), X-ray diffraction (XRD) and Scanning Electron Microscope (SEM-EDX). Optical bandgap energy (Eg) was computed using the range of 400nm-800nm wavelength. The estimated optical bandgap of the prepared glass samples varied from 2.60 eV up to 2.88 eV. As a conclusion, tellurite based oxide glass materials have become very much promising candidate in the areas like fiber optics, optical communication, white LED, quantum dot, quantum computing, laser technology, photonics and many other applications.
Influence of Land Use on Soil Microbial Communities of Sub Himalayas of India: Insights from Phospholipid Fatty Acid Profiles, Ribosomal Intergenic Spacer Profiles, Soil Enzymes, and Carbon Pools.
Authors: Kumar Arun Kumar K , Singh Raj Deo Singh , Sahu Sanjat Kumar Sahu
Published: June 2023

Land use and management practices have a significant impact on soil microbial populations and community composition, thereby influencing ecosystem processes. Soil microbial and biochemical indicators serve as highly sensitive tools for assessing the effects of land use systems. In this study, we investigated soils under ten different land use systems in the Central Himalayas, India, including natural forests dominated by oak (Quercus incana), deodar (Cedrus deodara), or pine (Pinus roxburghii) trees, orchards dominated by apple trees, and crop-based systems in uplands and valleys. We examined phospholipid ester-linked fatty acid (PLFA) profiles, soil enzymes, Ribosomal Intergenic Spacer Analysis (RISA) profiles, microbial biomass carbon and organic carbon as effected by land use. The results revealed that forest soils had significantly higher levels of soil enzymes compared to agricultural soils. Microbial biomass carbon and organic carbon showed a close relationship with the PLFA profiles across different land uses. Gram-positive bacteria (15:0 iso, 16:1 iso G, 16:1 iso H), gram-negative bacteria (10:0 2OH, 12:0 3OH, 17:0 cyc, 19:0cyc 8c, 18:1ω7c11), fungi (18:1ω9c), and arbuscular mycorrhizal fungi (AMF) (16:1) exhibited higher relative abundance in forest systems, whereas gram-positive PLFA markers (C15:0 anteiso, C17:0 iso, C17:0 anteiso) were more prominent in agro-ecosystems. Principal component analysis (PCA) of the PLFA profiles demonstrated that the microbial communities in deodar forest soils were compositionally distinct from other forest soils, while the cultivated soils were grouped together and exhibited higher similarity, except for the organic farming soil. The correlation between PLFA profiles and soil enzymes, microbial biomass carbon, and organic carbon provides insights into the impact of different land use and management practices on soil microbial health and, consequently, soil health.
3D Printed Fluidic Swab for COVID-19 Testing with Improved Diagnostic Yield and User Comfort
Authors: Kim Joochan , Jeon Jaehyung , Jang Hyowon , Moon Youngkwang , Abafogi Abdurhaman Teyib , Noort Danny van , Lee Jinkee , kang Taejoon , Park Sungsu
Published: June 2023

The current standard method of diagnosing coronavirus disease 2019 (COVID-19) involves uncomfortable and invasive nasopharyngeal (NP) sampling using cotton swabs (CS), which can be unsuitable for self-testing. Although mid-turbinate sampling is an alternative, it has a lower diagnostic yield than NP sampling. Nasal wash (NW) has a similar diagnostic yield to NP sampling, but is cumbersome to perform. In this study, we introduce a 3D printed fluidic swab (3DPFS) that enables easy NW sampling for COVID-19 testing with improved diagnostic yield. The 3DPFS comprises a swab head, microchannel, and socket that can be connected to a syringe containing 250 µL of NW solution. The 3DPFS efficiently collects nasal fluid from the surface of the nasal cavity, resulting in higher sensitivity than CS for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This was confirmed by both reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and lateral flow assays (LFA) in virus-spiked nasal samples and clinical samples. Additionally, users reported greater comfort when using the 3DPFS compared to CS. These findings suggest that the 3DPFS can improve the performance of COVID-19 testing by facilitating efficient and less painful nasal sample collection.
Minocycline mitigates tau pathology via modulating the TLR-4/NF-кβ signalling pathway in the hippocampus of Alzheimer disease’s rat model
Authors: Qaid Entesar Yaseen Abdo , Abdullah Zuraidah , Zakaria Rahimah , Long Idris
Published: June 2023

Introduction:
The neuroinflammatory response was seen to impact the formation of phosphorylated tau protein in Alzheimer’s disease (AD). This study aims to investigate the molecular mechanism of minocycline in reducing phosphorylated tau protein formation in the hippocampus of lipopolysaccharide (LPS)-induced rats.
Methods
Fifty adult male Sprague Dawley (SD) rats were randomly allocated to 1 of 5 groups: control, LPS (5 mg/kg), LPS + minocycline (25 mg/kg), LPS + minocycline (50 mg/kg) and LPS + memantine (10 mg/kg). Minocycline and memantine were administered intraperitoneally (i.p) for two weeks, and LPS was injected i.p. once on day 5. ELISA was used to determine the level of phosphorylated tau protein in SD rats' hippocampal tissue. The density and expression of Toll-like receptor-4 (TLR-4), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кβ), tumour necrosis factor-alpha (TNF-α), and cyclooxygenase (COX)-2 were determined using Western blot and immunohistochemistry.
Results
Minocycline, like memantine, prevented LPS-induced increase in phosphorylated tau protein level via reduced density and expression of TLR-4, NF-кβ, TNF-α and COX-2 proteins in rat hippocampal tissue. Interestingly, higher doses were shown to be more neuroprotective than lower doses.
Conclusion
This study suggests that minocycline suppresses the neuroinflammation signalling pathway and decreased phosphorylated tau protein formation induced by LPS in a dose-dependent manner. Minocycline has been recommended can be used as a preventative and therapeutic drug for neuroinflammatory diseases such as AD.
Investigations of CZEUM cultures reveal new genera and species of Cladochytriales (Cladochytriomycetes, Chytridiomycota)
Authors: Jeronimo Gustavo Henrique , Simmons D. Rabern , Longcore Joyce E , James Timothy Y. , Amses Kevin R. , Seto Kensuke , Pires-Zottarelli Carmen L.A.
Published: June 2023

Cladochytriales comprises a taxonomic order and lineage of chytrid fungi that are primarily saprobes of organic matter in aquatic and terrestrial ecosystems. The order contains species from twelve genera, though molecular confirmations of almost all type species are lacking, and many genera are considered polyphyletic. We conducted phylogenetic analyses of ribosomal RNA genes and developmental morphology comparisons of Cladochytriales isolates from the Collection of Zoosporic Eufungi at the University of Michigan and noted some strains that were distinct from described genera. The present phylogeny represents the most comprehensive analysis of Cladochytriales to date with three strongly supported clades, representing Cladochytriaceae, Nowakowskiellaceae and Septochytriaceae. Additionally, Endochytriaceae represented by only one strain of Endochytrium ramosum was sister to Septochytriaceae, Nephrochytrium sp. JEL125 was sister to Cladochytriaceae, while the incertae sedis lineage formed by the new species Thomazella caroliniana was sister to Nowakowskiellaceae. A thorough revision of the order is needed because some genera, such as Catenochytridium and Nephrochytrium, remain polyphyletic or paraphyletic. In addition to indicating these problems, our updated phylogeny supports the description of five new genera and six new species and thereby begins to bring the knowledge of the Cladochytriales up to date.
The relationship between self-confidence and attitude of prehospital emergency personnel towards family presence during resuscitation
Authors: Najafi Jaber , Gilani Neda , Ghafourifard Mansour , Hassankhani Hadi , Dadashzadeh Abbas , Zali Mahnaz
Published: June 2023

Background
The presence of family members during the resuscitation of patients is considered a controversial issue in the worldwide. The present study aimed to examine the prehospital emergency personnel self-confidence and attitude towards family presence during resuscitation (FPDR).
Methods
In this cross-sectional study, a random sample of 252 prehospital emergency personnel were selected from 110 prehospital emergency centers. Two main questionnaire was used to collect the data on the self-confidences and attitudes of the prehospital emergency personnel towards FPDR. The SPSS software (version 26) was used to perform the data analysis.
Results
The results showed that the standardized score of the personnel’ attitudes towards FPDR was lower than the mean value (43.69 ± 19.40). Furthermore, more than 85% of them stated that the resuscitation process was stressful for the patients’ companions. There was a positive correlation between the personnel’ self-confidence and their attitudes towards FPDR (r = 0.52, p < 0.01). The results showed that the smaller numbers of the present family members during resuscitation were associated with the personnel members’ higher levels of self-confidence and their more positive attitudes towards FPDR. Moreover, the personnel members who were highly experienced, had liability insurance, and had attended the advanced resuscitation courses were significantly more self-confident than the other personnel members.
Conclusion
A large number of the EMS personnel members have negative attitudes towards FPDR. Therefore, it is possible to improve the personnel members’ attitudes towards FPDR and to increase their self-confidence by recruiting experienced personnel and training them for resuscitation in the presence of family, ensuring the timely presence of the support team, and preventing the people from gathering at the resuscitation scenes.
Single-cell transcriptomic analysis reveals the functional heterogeneity and clinical signification of pericyte subpopulations in gliomas
Authors: Guo Ying , Liu Yu-Qi , Zhang Xiao-Ning , Liu Qing , Li Tian-Ran , Yin Wen , He Zhi-Cheng , Lv Sheng-Qing , Li Fei , Luo Chun-Hua , Luo Min , Wang Wen-Ying , Mao Min , Cheng Yue , Yang Ying , Wang Chao , Wu Chen-Chen , Ye Shuang-Hui , Niu Qin , Li Ding-Shan , An Le-Le , Yao Xiao-Hong , Shi Yu , Bian Xiu-Wu , Ping Yi-Fang
Published: June 2023

Gliomas are not only among the most vascular-rich solid tumors, but also the most common primary brain tumors. The vascular morphology and molecular characteristics of gliomas are heterogeneous. Pericytes are one of the important cell components in glioma vascular structure and are highly heterogenies. However, the heterogeneity of pericytes in gliomas is not clear, and the biological characteristics and clinical significance of different subpopulations of pericytes are still unknown. An in-depth understanding of pericyte characteristics based on gene expression profiling, as well as the correlation of pericytes and the clinical prognosis of glioma are important prerequisites for the development of follow-up targeted vascular therapy. In this study, the heterogeneity of pericytes in glioma was revealed by single-cell RNA sequencing technique, the relationship between pericyte subpopulations and patient survival, prognosis and treatment response were clarified, and the MMP9+ pericytes were identified as a unique pericyte subpopulation in the core area of glioma, providing theoretical basis for analyzing the characteristics of vascular microenvironment of glioma and new targets for anti-vascular therapy of glioma.
Synthesis and characterization of magnetic oxide nanoparticle-impregnated natural clay for environmental remediation: Removal of Acid Fuschin from medical laboratory wastewater through adsorption
Authors: Ahmed Harez Rashid
Published: June 2023

This study presents a novel approach to utilizing natural clay, specifically those with high smectite content, impregnated with magnetic oxide nanoparticles (Fe3O4) for Acid Fuschin Dye (AFD) adsorption from aqueous solutions. The results indicate that Fe3O4-Natural Clay demonstrated significant potential for AFD removal through traditional adsorption processes. The effective Magnetic Oxide Nanoparticle-impregnated Natural Clay (MON) was characterized using XRD, SEM-EDS, FTIR, and N2 adsorption-desorption techniques, confirming a porous surface structure with a high surface area. The adsorption capacity of AFD for MON was found to reach equilibrium after 60 to 120 minutes, with an initial pH of 9. The Pseudo-Second-Order model accurately described the chemisorption process of AFD adsorption, while the Freundlich isotherm model consistently provided a better fit for the data than the Langmuir model. The thermodynamic analysis of the MON adsorbent revealed that adsorption was exothermic and spontaneous, with entropic changes at the solid-liquid interface. The results suggest that the adsorption of AFD dye was favorable for the system's enthalpy but unfavorable for its entropy. Given the high surface area and enhanced adsorption capacity of MON, it shows great potential as a promising adsorbent for AFD removal in wastewater treatment.
Evaluation of epidemiological mapping strategies and diagnostic tool for onchocerciasis and lymphatic filariasis in hypo-endemic Amaya district, South-Western Ethiopia
Authors: Taddese Boja Dufera , Indris Hassen Mamo , Tafa Bacha Mekonnen , Semu Seble Seifu , Keshamo Legesse Negash , Mohammed Ahlam Awad , Barbre Kira , Aragie Solomon , Guma Geremew Tasew , Gass Katherine , Feleke Sindew Mekasha
Published: June 2023

Onchocerciasis is a parasitic neglected tropical disease caused by a filarial nematode called Onchocerca volvulus. During the period of the onchocerciasis control program in Ethiopia, larger areas with onchocerciasis prevalence of less than 20% were classified as hypo-endemic. In 2012, the goal of the program has been shifted from control to elimination, which required the evaluation of mapping strategies and assessment of transmission status. However, there is no clear mapping strategy for onchocerciasis and lymphatic filariasis in the elimination context in these areas. Hence, the study evaluated the mapping strategies in first-line and randomly selected villages and matched school children to random villages.
Methods
A cross-sectional study involving a total of 2756 study participants; 1181 from four purposively selected first-line villages, 372 from random villages, and 1203 from matched schools children to random villages was conducted in 2019 at Amaya district South-western Shoa zone of Oromia region of Ethiopia. Approximately 175 µL finger prick blood was collected from each study participant. Oncho/LF IgG4 bi-plex rapid diagnostic test was conducted using 10 µL blood and dried blood spot were prepared using the remaining blood samples for further conformation by SD-ELISA. Data were captured using open data kit software programmed tablet, exported, and analyzed by SPSS version 23 software. The sensitivity and specificity of the Oncho/LF IgG4 bi-plex test were evaluated against SD-ELISA as the reference standard based on the manufacturer’s claims.
Results
The prevalence of onchocerciasis among first-line, randomly selected villages and matched-school children in random villages were 8.3%, 4.6%, and 0.33% respectively. The prevalence of lymphatic filariasis in first-line villages was 1.02%, while 1.1% in random villages. The co-endemicity of onchocerciasis with lymphatic filariasis was 0.42% in the first line and 1.08% in randomly selected villages. The sensitivity and specificity of the Oncho/LF IgG4 bi-plex test were 26.09 % and 99.93%.
Conclusions
The study indicated Amaya district qualifies for onchocerciasis mass drug administration threshold (>2%) average in both first-line and randomly selected villages. In both first and random villages, onchocerciasis and lymphatic filariasis were co-endemic indicating the need of integrating mapping strategies. First-line and random village-based mapping strategies are recommended for onchocerciasis in hypo-endemic areas.
CCTA-based CABG SYNTAX Score: A Tool to Evaluate Completeness of Coronary Segment Revascularization after Bypass Surgery
Authors: Kotoku Nozomi , Serruys Patrick W. , Kageyama Shigetaka , Garg Scot , Masuda Shinichiro , Ninomiya Kai , Grau Juan B. , Gupta Himanshu , Agarwal Vikram , Morel Marie-Angèle , Doenst Torsten , Schneider Ulrich , Tanaka Kaoru , LaMeir Mark , Mushtaq Saima , Gianluca Pontone , Pompilio Giulio , Teichgräber Ulf , Puskas John , Narula Jagat , Mey Johan , Andreini Daniele , Onuma Yoshinobu
Published: June 2023

Purpose
To describe the updated coronary computed tomographic angiography (CCTA)-based coronary artery bypass graft (CABG) anatomic SYNTAX Score (aSS) and assess its utility and reproducibility for assessing the completeness of revascularization after CABG.
Methods
The CCTA-CABG aSS is a visual assessment using CCTA post-CABG which quantifies the failure in effectively grafting stenotic coronary segments, and therefore assesses the completeness of surgical revascularization. It is calculated by subtracting the aSS of successfully anastomosed coronary segments from the aSS of the native coronary tree. The inter-observer reproducibility of the CCTA-CABG aSS was evaluated in 45 consecutive patients with three-vessel disease with or without left main disease who underwent a CCTA 30 days (±7 days) after CABG.
Results
The CCTA-CABG aSSwas evaluated in 45 consecutive patients with 117 bypass grafts and 152 anastomoses. The median native coronary aSS was 35.0 (interquartile range [IQR]: 27.0-41.0), whilst the median CCTA-CABG aSS was 13.0 (IQR: 9.0-20.5). The inter-observer level of agreement for the native coronary aSS and the CCTA-CABG aSSwere both substantial with respective Kappas of 0.67 and 0.61.
Conclusions
The CCTA-CABG aSS was feasible in all patients who underwent CABG for complex coronary artery disease with substantial inter-observer reproducibility, and therefore can be used to quantify the completeness of revascularization after CABG.
Ionospheric Total Electron Content and Scintillation Variations over Uzbekistan and China GPS stations during the Annular Solar Eclipse on 21 June 2020
Authors: Eshkuvatov H.E , Ahmedov B.J
Published: June 2023

In this study, we utilized both ground‐based and space‐borne observations including total electron content (TEC) from GPS satellites. We investigate in detail variations of ionospheric Total Electron Content (TEC) and Ionospheric Scintillation Index S4 during the annular Solar eclipse that occurred on 21st June 2020 over selected sites. We choose six stations MTAL, KIT3, and MADK in Uzbekistan, and JFNG, LHAZ, and BJFS in China which are located close to the path of the Solar eclipse with obscuration $52\%$, $57\%$, $58\%$, and $92\%$, $94\%$ and $95\%$, respectively. The Ionospheric parameters as TEC and S4 index have been analyzed for continuous three days from 20th to 22nd June 2020. A significant amount of depletion in TEC of the order of 10-30 $\%$ has been observed concerning the solar eclipse day. The results of the performed analysis indicate that the TEC level and S4 scintillation index were decreased during the solar eclipse due to the contraction of ionizing radiation.
Molecular characterization of Klebsiella pneumoniae in clinical bovine mastitis in 14 provinces in China
Authors: Wusiman Maierhaba , Zuo Jiakun , Yu Yong , Lv Zhaoyang , Wang Mengdi , Nie Lianhua , Zhang Xiuping , Wu Jing , Jiang Wei , Pan Zihao , Zhang Wei , Yin Huifang , Huang Cuiqin , Chen Zhaoguo , Miao Jinfeng , Chen Wei , Han Xiangan
Published: June 2023

Klebsiella pneumoniae (K. pneumoniae) is a major common environmental pathogen which causes bovine mastitis. To investigate the epidemic of K. pneumoniae of China, 131 K. pneumoniae strains were isolated from 495 clinical mastitis milk samples from 14 provinces in China. The isolation rate of K. pneumoniae was 26.5%, and K57 was the dominant serotype (45.0%, 59/131). Nineteen (14.5%) isolates were identified as hypervirulent K. pneumoniae (hvKP) and nine of them belonged to the K57 serotype. The mrkA, entB, wabG and fimH genes were prevalent virulence genes while rmpA, magA and ycf were not found in K. pneumoniae. Furthermore, K. pneumoniae had serious drug resistance and multiple beta-lactamase genes were detected, including blaTEM, blaSHV, blaNDM, blaCTX-M, blaDHA and blaKPC. Biofilm was an important factor in bacterial resistance and persistent infection, and 77.1% isolates could form biofilm. Although acylated homoserine lactone (AHL, a Gram-negative bacterial quorum sensing signal molecule) was not confirmed among the K. pneumoniae isolates, exogenous AHLs could reduce the biofilm formation ability of the K. pneumoniae strains. In conclusion, the high rate of isolation and serious antibiotic resistance of K. pneumonia were found in this study and indicated a potential threat to public health from the food chain.
MED-BOT (An AI Doctor)
Authors: R BANU PRAKASH , S SARAVANAN
Published: June 2023

MED-BOT is a chatbot program that utilizes PHP and a MySQL database to recommend medicines based on user symptoms. The chatbot features a backend chat support for doctors to provide medical assistance to patients. The program can be easily integrated into existing web-based chat applications, and can be customized to suit the specific needs of medical professionals and patients. The MED-BOT chatbot connects to a MySQL database to retrieve user input and chat IDs. It then searches the triggers table for matching triggers based on user input. If a trigger is found, the corresponding response is retrieved from the database and displayed to the user. If the response is intended for a doctor, the chatbot updates the chat’s doctor ID and outputs the response to all doctors. The MED-BOT chatbot can be easily customized to suit different medical scenarios. For example, the chatbot could be adapted to provide first-aid advice or help users identify common symptoms of a specific illness. By leveraging the power of PHP and MySQL, the chatbot can handle a wide range of medical queries, and provide a seamless user experience for patients seeking medical advice. The MED-BOT chatbot could also be used in a hospital setting to help doctors and nurses provide quick and accurate diagnoses for patients. For instance, if a patient presents with certain symptoms, the chatbot could suggest the most likely diagnosis and recommend a course of treatment. This would allow medical professionals to make informed decisions quickly, and improve patient outcomes. In conclusion, the MED-BOT chatbot is a powerful tool that can help medical professionals and patients alike. It utilizes PHP and a MySQL database to provide accurate medical advice and recommendations, and can be customized to suit a wide range of medical scenarios. By leveraging the power of chatbots, medical professionals can provide better care to patients, and patients can access medical advice quickly and conveniently.
Effect of different surgical options on the long-term survival of stage I gallbladder cancer: A retrospective study based on SEER database and Chinese Multi-institutional Registry
Authors: Ji Zuhong , Ren Ling , Liu Fang , Liu Lei , Song Jing , Zhu Juntao , Ji Guozhong , Huang Guangming
Published: June 2023

Background
Gallbladder cancer (GC) is a uncommon and highly malignant tumor. This study compared the effects of simple cholecystectomy (SC) and extended cholecystectomy (EC) on the long-term survival of stage I GC.
Methods
Patients with stage I GC between 2004 and 2015 in the SEER database were selected. Meanwhile, this study collected the clinical information of patients with stage I GC admitted to five medical centers in China between 2012 and 2022. Using clinical data from patients in the SEER database as a training set to construct a nomogram, which was validated in Chinese multicenter patients. Long-term survival between SC and EC were distinguished using propensity score matching.
Results
A total of 956 patients from the SEER database and 54 patients from five Chinese hospitals were included in this study. The independent prognostic factors were age, sex, histology, tumor size, T stage, grade, chemotherapy and surgical approach by multivariate Cox regression analysis. We developed a nomogram based on these variables. The nomogram has been proved to have good accuracy and discrimination in internal and external validation. The cancer-specific survival (CSS) and overall survival of patients receiving EC were better than those of SC before and after the propensity score match. The interaction test showed that EC was associated with better survival in patients aged ≥ 67 years (P = 0.015) and in patients with T1b and T1NOS (P < 0.001).
Conclusion
A novel nomogram to predict CSS in patients with stage I GC after SC or EC. Compared with SC, EC for stage I GC had higher OS and CSS, especially in specific subgroups (T1b, T1NOS, and age ≥ 67 years).
Anatomical Information of the Lenticulostriate Arteries on High-Resolution 3D-TOF MRA at 3T: Comparison with 3D-DSA
Authors: Takahashi Sanae , Gomyo Miho , Tsuchiya Kazuhiro , Yoshioka Tatsuya , Kobayashi Kuninori , Nakanishi Akihito , Yokoyama Kenichi
Published: June 2023

Purpose As the lenticulostriate arteries (LSAs) perfuse neurologically important areas, it is necessary to accurately assess the origin and number of the LSAs before surgery. Although three-dimensional time-of-flight angiography (3D-TOF MRA) is a non-invasive procedure, it requires high-resolution (HR) images to depict LSAs with a small diameter. Therefore, we performed 3D-TOF MRA with the maximum HR using 3T-MRI (HR-MRA) to examine whether a good depiction of the LSAs, equivalent to that of digital subtraction angiography (DSA), could be obtained.
Methods Our study group comprised 16 consecutive patients who underwent HR-MRA and 3D-DSA. In both studies, we evaluated the following issues that include the localization of the origin from M1, M2, and A1 segments, their number of stems, and depiction.
Results There was no significant difference in the visualization of the LSAs between HR-MRA and 3D-DSA (P-values; M1, M2, and A1=0.39, 0.69, and 0.69, respectively), and both the number of stems and the localization of the origin of the LSAs were the same between them.
Conclusion Good depiction of the LSAs can be obtained using HR-MRA with 3T-MRI, and the number of stems and the location of the origin of LSAs can be evaluated almost identically to that obtained by 3D-DSA.
The ABC Model of Positive Feelings: A Preliminary Test
Authors: Tiba Alexandru , Drugaș Marius , Sîrbu Ioana , Trip Simona , Bora Carmen , Miclăuș Daiana , Voss Laura , Sanislav Ioana , Ciurescu Daniel
Published: June 2023

Introduction
According to the ABC model of positive feelings, responding to positive activating events with irrational beliefs will result in dysfunctional positive feelings. Positive emotional disturbance is an important marker of bipolar spectrum disorders. Evidencing the role of irrational beliefs in dysfunctional positive feelings may have important clinical implications. However, no study has tested this model. Here, we tested the ABC model of positive feelings based on the REBT model of emotion.
Method
115 participants had to imagine eight unexpected anticipatory positive situations. Then they reported how vividly they imagined the situations, and what they would believe and feel if they were in each situation. After that, they completed a hypomania scale, a general measure of positive irrational beliefs, and a general measure of irrational beliefs about adverse events.
Results
Results showed that situational positive primary irrational beliefs mediate the effect of vividness of imagining positive situations on dysfunctional positive feelings (b = 2.436, 95% CI: LL = 1.314 to UL = 3.832) while situational preferences mediated the effect of positive events on functional positive feelings (b = 0.642, 95% CI: LL = 0.165 to UL = 1.209). Moreover, the effect of positive primary irrational beliefs on dysfunctional positive feelings was mediated by secondary positive irrational beliefs such as positive intolerance (b = 3.826, 95% CI: LL = 0. 370; to UL = 7.740), and extreme self-valuing (b = 1. 330, 95% CI: LL = 0.287 to UL = 2.471) but not by wonderfulizing (b = 0.061, 95% CI: LL= -3.337 to UL = 3.298).
Conclusions
Evidencing an ABC model of positive feelings and showing the role of irrational beliefs in dysfunctional and functional positive feelings may advance existing treatments for promoting mental health and reducing the disturbances of positive emotions.
Interação entre Bisfosfonatos e a Implantodontia: Uma Revisão de Literatura
Authors: Casotti Ariel Mateus , Fernandes e Oliveira Hiskell Francine , Souza Ana Carla Gonçales de , Mendes Rafael Carlos , Saliba Marcos Tadeo Adas , Ferreira Jean Paulo Rodolfo , Verri Fellippo Ramos
Published: June 2023

Os bifosfonatos são um grupo de medicamentos usados para prevenir e tratar doenças ósseas, como osteoporose. Embora os bifosfonatos sejam eficazes no tratamento dessas condições, também podem ter efeitos colaterais indesejados, como osteonecrose da mandíbula/maxila e outras condições. Foram recuperados artigos indexados na base de dados Scientific Eletronic Library Online (SciELO), PubMed e Biblioteca Virtual em Saúde (BVS) Odontologia. Realizou-se a busca, sendo estabelecido previamente o período de 5 anos (2018 a 2022), visando identificar um panorama mais atual sobre o tema. Os critérios utilizados para inclusão das publicações foram: artigos científicos brasileiros com texto completo disponível, publicação no período de 2018 a 2022, conter expresso no título, palavras-chave e/ou resumo que o texto se referia a interação de bifosfonatos com implantes dentários. Foram descartados artigos de revisão, bem como aqueles provenientes de dissertações e teses. A consulta à base de dados da plataforma SciELO, PubMed e BVS Odontologia e a aplicação das estratégias de busca resultou em 12 artigos. Diante dos achados, um artigo (8,3%) é do ano de 2018, seis (50%) são de 2019, dois (16,6%) são de 2020, um (8,3%) de 2021 e um (8,3%) de 2022. Os artigos que compuseram a amostra final foram organizados. Evidenciou-se que os artigos selecionados abordam os seguintes temas associados à implantes e bifosfonatos: osteonecrose da mandíbula/maxila (38%), menopausa (8%), diabetes mellitus tipo 2 (8%), osseointegração (8%), estabilidade de implantes (15%), osteoblastos (8%), enxerto ósseo (8%). Diante dos achados, faz-se importante que os profissionais da saúde estejam atentos a pacientes usuários de bifosfonato para informá-los dos potenciais riscos e benefícios de se realizar procedimentos cirúrgicos como os implantes dentários.
Biochemical Changes Between Rapid And Conventional Orthodontic Tooth Movement: A Comparative Studya
Authors: Trehan Mridula , Ankita Pandey  , Nidhi Agrawal  , Sunil Sharma  , Nidhi Rathore  , Shantanu Sharma
Published: June 2023

Background: Accelerated orthodontics has revolutionized the field of orthodontic treatment. Reducing the overall treatment time remains the prime concern of an orthodontist. A good accelerating technique should be affordable, repeatable, practical, efficient and should not have any side effects on periodontium including root and alveolar bone. In the era of technology, many advances are made and newer techniques for accelerating orthodontic tooth movement have been introduced in order to reduce the length of treatment with minimal risk of side effects. This study was conducted to compare the biochemical changes in rapid and conventional orthodontic tooth movement.

Materials and Method:A split mouth study was conducted on thirty patients undergoing fixed orthodontic treatment requiring all four first premolar extraction. The extraction space closure, was carried out with micro osteoperforations on the distal aspect of both the maxillary canines along with orthodontic force application as experimental site on the right side and conventional orthodontic tooth movement as control site on the left side. GCF was collected before the micro osteoperforation (T0), at day 3 (T1), at day 7 (T2) and at 4 weeks (T3) of initiating canine retraction from the distal gingival crevice of both the maxillary canines. Quantitative analysis of IL-1 and Osteocalcin in GCF sample was assessed using enzyme linked immune sorbent assay. The optical density of samples was calculated using a fully automated enzyme linked immunosorbent assay reader.

Result: The level of Interleukin-1and Osteocalcin was always higher at the micro osteoperforation site compared to that of baseline values.

Conclusion:A gradual increase in the levels of IL-1 and Osteocalcin was observed in both the conventional and micro osteoperforation site but statistically significant elevated levels of IL-1 and Osteocalcin were seen in micro osteoperforation site compared to conventional site.
An Ex-vivo Comparative Evaluation of Apical Debris And Irrigant Extrusion From Curved Canals Using Three Different Ni-Ti Instruments With Conventional Irrigation Methods.
Authors: Dr. Poonam Sardar  , Dr. Baljeet Singh Hora  , Dr. Chitra Gohil  , Dr. Krutika Borkar  , Dr. Yadnesh Dondulkar  , Dr. Harsh Jain
Published: June 2023

An Ex-vivo Comparative Evaluation of Apical Debris And Irrigant Extrusion From Curved Canals Using Three Different Ni-Ti Instruments With Conventional Irrigation Methods.

 

 

Abstract-

 

Aim: The present study aimed to compare and evaluate debris and irrigant extrusion from curved root canals using different Ni-Ti systems.

 

 

Materials and Method: 30 single rooted mandibular premolars were used in this study. Crown was decoronated, working length and initial apical diameter was established. 1.5% agar gel model was used in this study. Samples were assigned randomly into 3 groups (n = 10 teeth per group). Protaper Next, OneShape, NT GOLD files were used according to the manufacturers’ instructions for canal instrumentation. Apically extruded debris and irrigant was computed by deducting the initial weight of the test apparatus without a tooth from its weight after the biomechanical preparation. Comparative analysis of the amount of apically extruded debris and irrigant for each of the instruments and the experimental models was performed.

Results: Statistically significant difference was found between the three experimental groups. (P <.05). Amid all the groups least extrusion was observed in the Protaper Next group when used in combination with conventional irrigation

Conclusion: All the instruments produced apically extruded debris and irrigant, but maximum was seen with OneShape among the experimental groups.

Keywords: Apically extruded debris and irrigant, NT Gold, ProtaperNext, OneShape
Rehabilitation of severly resorbed mandibular ridge with implant supported overdenture with magnet attachment : A case report.
Authors: Srivastava Dr. Rajeev , Khandelwal Dr. Sourabh , Choukse Dr. Vivek , Mundra Dr. Pallavi
Published: June 2023

Magnets have been used widely in the field of dentistry for many years with some success, as they can be manufactured in small dimensions as a retentive devices in overdenture technique, maxillofacial prosthesis and obturators. These magnet attachment attached to osseointegrated implants which transfer the occlusal load to the bone, thereby prevent resorption of remaining alveolar bone and improves the retention and stability of the denture. Magnetic assembly consist of magnet and  ferromagnetic metal keeper. More recently, magnets have been made from alloys of the rare earth elements samarium and neodymium, which provides stronger magnetic force per unit size. Magnets are sealed by means of the latest laser lasing techniques thus protect magnet from corrosion in oral cavity. The present article demonstrates the rehabilitation of completely edentulous patient with the help of implant supported mandibular overdenture with magnet attachment and conventional maxillary denture.
Inlay-Retained Aesthetic Fixed Prosthesis Using Monolithic Zirconia: A Case Report
Authors: Aishwarya Roy  , Rashmi Bansal  , Abhinay Agarwal  , Mrityunjay Kumar
Published: June 2023

Various indirect restorations to restore a single missing tooth in the posterior region are available in dentistry such as traditional full coverage fixed dental prostheses, implant-supported crowns, and inlay-retained fixed prosthesis. Resin bonded FDPs represent a minimally invasive procedure; preexisting fillings can minimize tooth structure removal and give retention to the IRFP, transforming it into an ultraconservative option. New high strength zirconia ceramics, with their stiffness and high mechanical properties, could be considered a right choice for an Inlay retained aesthetic fixed prosthesis rehabilitation. The case report describes an IRFP treatment using a CAD/CAM monolithic zirconia. Clinical and laboratory steps are illustrated, according to the most recent scientific protocols. Pleasing esthetic and better functional integration of indirect restoration at six months follow-up confirmed the success of this conservative approach.
Contemporary Distraction Tools Used In Pediatric Dentistry: An Overview
Authors: Nur Fatma
Published: June 2023

Behavior management is widely accepted by many clinicians and is one of the important factors in providing dental care to children. If the child’s behavior cannot be managed accordingly, then it is almost impossible to perform the dental procedures that are needed. Thus, Professional recognition of these difficulties significantly heightened the interest in behavior management and led to the development of a various well-established child behavior management armamentarium for dentist to reduce child’s anxiety in dentistry. And distraction technique is one among them which has gained increasing polpularity due to evolving technology and leading researches. Thus, this articles reviews the various evolving and promising cost- and time-effective distraction techniques of behaviour management used in pediatric dentistry. Articles from primary, secondary, and tertiary literature were selected for inclusion on relevance and significance to the clinician.
Effect of Non-surgical Periodontal Therapy on Viruses- HSV, EBV and HCMV using Multiplex PCR in Chronic Periodontitis Patients.
Authors: Rachalwar Shweta , Kalburgi Veena , Nimmala Sai Sri Harsha , Gupta Anushri , Chakkarwar Yash , Trivedi Akhil
Published: June 2023

Periodontitis, the most common periodontal pathology, is a chronic disease orchestrated amongst the infectious organisms and humoral and cellular immune responses of the host.2 Initially only the bacteria like Treponema Denticola, PorphyromonasGingivalisand Tannerella Forsythia were linked with the disease and hence the term periodontal microbiology was recoined as periodontal bacteriology. The hunt for the etiology however did not end here as many patients still did not fall into this domain of causative factors. This tickled the researchers to put on their thinking caps when they pondered over viruses being the unexplained etiology. Multiplex PCR is the simultaneous detection of multiple targets in a single reaction well, with a different pair of primers for each targets. This technique is indispensable with two or more probes that can be distinguished from each other and recognized simultaneously.
Incidence of Maxillary Sinus Abnormalities in Asymptomatic Patients: A CBCT Study.
Authors: Choudhary Anand choudhary , Kesarwani Pallavi , K SRIKRISHNA , VERMA SAUMYA , VERMA SUGANDHA , KUMAR ASHUTOSH
Published: June 2023

Abstract

Background:  Cone beam computer tomography (CBCT) when imaged for maxillary jaw generally depicts maxillary sinus. This region is frequently neglected by dentist and maxillofacial radiologist. Signs and symptoms in odontogenic diseases of the jaw and the maxillary sinus may overlap each other. A dental surgeon primarily encounters these lesions in routine dental radiographs..

Aim:  The  present study was undetaken to evaluate the occurrence of maxillary sinus anomalies in CBCT images of asymptomatic patients and to determine their  prevalence, type and location.  

Materials and methods: Study consisted of 256 CBCT images of the patients depicting maxillary sinus who has been advised limited volume CBCT  as part of routine dental investigation for implant planning, orthodontic assessment, oral surgical procedure, oral pathology etc.. The CBCT images were scrutinized  for various  maxillary sinus pathologies like mucosal thickening, opacification,  polyp and retention pseudocyst

Result: Out of 236 subjects, 106 (44.9%) presented with maxillary sinus abnormalities. The maxillary sinus abnormalities which were found in the study were as follows,  mucosal thickening 60 (25.4%), opacification 32 (13.6%), sinus polyp  8 (3.4%) and retention pseudocyst 6 (2.5%). Right maxillary sinus were involved in 58 (24.6%) cases and left in 44 (18.6%) cases respectively, whereas bilateral sinus involvement was seen in 4 (1.7%) cases.

Conclusion: The results are suggestive of high incidence of abnormalities in asymptomatic maxillary sinus. Thus a prompt recognition of these abnormalities by dental surgeons and referral to specialist may help in treating these diseases at an early stage.
Parents perceptions and support for e-learning of Dental undergraduate students during Covid-19 lockdown
Authors: T Dr.  Sreenivasa Bharath, , Guduri Dr. Vineeth , Pasupuleti Dr. Mohan Kumar , Alla DR. Ramakrishna , N Dr. Rajesh , R Dr. Sudhakarareddy
Published: June 2023

Objectives: The study's objective was to implement effective education strategies and to record parents' perceptions of e-learning based on their children's advantages and challenges in attaining knowledge during the lockdown.

Methods: A total of 363 parents of students participated in the study. Based on the academic year of their children, 363 parents of dental students were categorized into four groups as parents of I BDS (93), II BDS (89), III BDS (93), and IV BDS (88). After introducing the e-learning system to all the students, the effectiveness of e-learning tools was evaluated by feedback forms. Demographics and background information, online teaching and learning methods, benefits and challenges, technical support by the faculty were assessed from the parents through Google forms to know whether their wards benefited through online teaching.

Results: 85.9% of parents said that their wards were well engaged due to the online education system. 80.2 % of parents were satisfied with the institution's overall online education pattern. On a scale of 0 to 5, 33.9% of parents rated excellent for the faculty and management's efforts during online classes. 86.2 % of parents believed that their wards were benefited due to the online education system.

Conclusion: The new system of e-learning managed to share the material, conducted assignments, and discussed exceptional cases of dental specialties to retain knowledge among the dental students during this lockdown. All the parents were happy enough that their wards had benefited absolutely from the online education system.
Shadow banking and micro-, small and medium scale enterprises: A municipal assessment in Nigeria
Authors: Ogar Anthony , Anyadighibe Joseph , Abanbeshie Jeremiah , Etuk Aniebiet , Eja Basil
Published: June 2023

Shadow banking is usually considered as offering financial and financial-related support outside of the mainstream conventional financial system. The biggest issue facing micro-, small, and medium-sized businesses (MSMEs) in Nigeria is the inconveniences and challenges associated with obtaining funds or credit from conventional banks, which encourages remote business operations and small-scale expansion. Thus, shadow banking activity is still widespread among MSMEs in Nigeria. This study used MSMEs operating in the Marian and Watt markets to analyze the impact of shadow bank interest income, savings products, and loans on the performance of MSMEs. A systematic Likert scale questionnaire was given to a group of 160 people, with 157 questionnaires duly returned. The survey research design was adopted, while the SPSS software was used to analyze the data acquired. As such, shadow banking interest income has a non-significant positive impact (0.022%) on the performance of MSMEs in Calabar metropolis; shadow banking savings products have a negative but significant impact (–0.160%) on MSME performance in Calabar metropolis, while shadow banking loans have a positive and significant effect (0.194%) on micro-, small, and medium-scale firm performance in Calabar metropolis. The study concluded that shadow bank operators should ensure that their service costs are standardized and supplied at affordable rates to attract MSMEs to patronize them for more successful business operations.