bluuebunny/crossref_metadata_2025 huggingface dataset:
Around the world in 1500 SNPs: cross-kingdom genomics across global taxa highlights optimised sampling for accurate genetic diversity assessments
Authors: Brunton Aaron , Farleigh Keaka , Brunton Elizabeth , Cristescu Romane , Ross  , Hohweiler Katrin , Holmes Bonnie , Kozakiewicz Chris , Levengood Alexis , Schoeman David , Ogbourne Steven , Conroy Gabriel
Published: January 2025

Population genetics is rapidly evolving in the genomics era, with next-generation sequencing providing researchers with access to vast and diverse genetic datasets. While these advancements present significant opportunities, key questions remain about the optimal sample sizes and number of genetic markers, such as single nucleotide polymorphisms (SNPs), needed for robust studies. This is particularly relevant to conservation genetics, where large sample sizes may be impractical for rare species or fragmented populations. To address these challenges, we analysed a global dataset of genotypes derived from various DNA sources (scat, blood, animal tissue, leaf) to explore how sample size and SNP count affect estimates of genetic diversity. Our findings showed that a sample size of ten individuals, combined with 1500 SNP markers, can provide accurate genetic diversity estimates across diverse taxa and sequencing approaches. Sensitivity analysis and random resampling revealed that a small sample size can reliably capture within-population diversity with minimal error, challenging traditional assumptions that larger sample sizes are always necessary for meaningful genomic insights. Although some taxa displayed instability in heterozygosity indices at smaller sample sizes, stability was typically reached within two to ten individuals and between 500-1500 SNPs. This study not only provides practical guidelines for efficient genomic assessments but also emphasises the potential for smaller, more targeted sampling strategies in biodiversity conservation. By integrating empirical findings with theoretical frameworks, we lay the groundwork for future research and resource-efficient approaches that address contemporary conservation challenges without compromising data accuracy.
A Feasibility Study of Urban Green Space Design in the Form of Smart Arid Landscaping with Rainwater Harvesting
Authors: Askari Kaveh Ostad Ali
Published: January 2025

This study proposes a method for designing a smart arid landscaping for urban green spaces, industrial and administrative units together with rainwater harvesting. Considering the zone with a suitable slope and two permeable and impermeable layers with a drainage network between them, runoff from rainfall can be harvested. To avoid installation of various drainages with no economic benefits, rhombus-shaped systems are created collect and carry the rainfall into the enterance of the drainages that transport water to the target reservoir. This method significantly increases the economic profitability, reduces water consumption, optimally uses harvested water and help maintaining water reservoirs. Environmental data, including daily rainfall, runoff from rainfall, evaporation and temperature of the soil, are monitored to assess the design. Results from this design indicate that runoff from rainfall and soil moisture increase up to twice and 5%, respectively. Another benefit is that soil heat and evaporation declining which leads to reduction of water consumption in target green spaces.
Cacao Plant Disease Detection and Classification
Authors: Tovurawa Emmanuel , Dlamini Blessing , Moore Stephen E. , Marivate Vukosi , Modupe Abiodun
Published: January 2025

Food security is a vital aspect of the United Nations’ Sustainable Development Goals (SDGs) which aims to promote sustainable farming in the world. Farming-driven economies such as Ghana are faced with challenges due to plant diseases. Cacao, a vital crop in Ghana is severely impacted with diseases which affect its yield and decrease exports revenue through reduced exports. Leveraging deep learning techniques offers an effective solution for early detection of diseases in cacao plants. This study adopts a comprehensive approach, starting with an Exploratory Data Analysis (EDA) of the dataset containing images of both healthy and diseased cacao plants from Ghanaian farms. Using exploratory data analysis (EDA), we can identify patterns and understand the characteristics of the dataset, laying a solid foundation for developing robust machine learning models tailored to the specific challenges faced by Ghanaian cacao farmers. Our approach involves developing and evaluating deep learning models to detect and classify cacao plant diseases. These models are designed with the Predictability, Compatibility, and Stability (PCS) framework in mind, ensuring reliability and effectiveness in disease detection. The custom convolution neural network (CNN) model outperformed other models considered in experimental analysis. This study aims to revolutionize cacao farming through precise, stable, and ethical deep learning solutions, ultimately enhancing crop resilience, productivity, and the livelihood of Ghanaian farmers.
BloodCircR: A Comprehensive Database for Human Peripheral Blood Circular RNAs
Authors: Yuan Shaoxun , Gu Wanjun
Published: January 2025

Background: Blood circular RNAs (circRNAs) are stable, noncoding RNAs with diverse functional roles. However, a comprehensive resource for blood-derived circRNAs is lacking. We developed BloodCircR, a database of circRNAs from human peripheral blood, to support research on circRNAs in disease and biomarker discovery.
Methods: BloodCircR integrates circRNAs identified from 89 human blood RNA-seq datasets, comprising 5,430 samples across 58 diseases categorized into 16 groups. Full-length circRNAs were identified using CIRI-full and supplemented with data from public databases. The platform provides detailed annotations and tools for exploring circRNA expression and differential expression.
Results: The database includes approximately 2.3 million circRNAs, of which over 1.7 million are exonic. Most circRNAs are full-length, with a substantial proportion derived from infectious disease datasets. Functional annotations suggest their interactions with miRNAs and RNA-binding proteins, while expression analysis supports the investigation of circRNA roles in disease.
Conclusions: BloodCircR is a comprehensive resource for exploring circRNAs in human blood, offering significant insights into their potential as biomarkers and therapeutic targets.
Svijet kao ideja u Kantovoj filozofiji
Authors: Vlaški Stanko
Published: January 2025

To da je svijet kao cjelina za čovjeka nespoznatljiv jedan je od glavnih zaključaka Kantove kritike uma. Pobliže, pojmom svijeta – a svijet se za Kanta otkriva, prije svega, kao jedan od pojmova uma, ideja – ne spoznaje se ništa, jer tom pojmu ne odgovara ništa u ljudskom iskustvu. Autor nastoji pokazati da ključni problem metafizičke kozmologije za Kanta nije u tome što je ona svojim pojmom svijeta poticala um da teži k onom nadiskustvenom i bezuvjetnom, već to što je pretpostavljala da te težnje svoje ispunjenje mogu pronaći u sferi teorijskog znanja. Za Kanta, naprotiv, one se ostvaruju jedino praktički, te se i pitanje o svijetu kao cjelini primarno pokazuje kao pitanje djelovanja. Zadatak uspostavljanja svijeta u njegovu inteligibilnom liku, onakvog kakav treba biti ili carstva svrha, u osnovi je učenja o kategoričkom imperativu. To je uspostavljanje kod Kanta shvaćeno kao beskonačni proces. Autor će se osvrnuti i na političko-povijesne i religijske aspekte Kantove teze o svijetu kao ideji uma, ali i na Hegelov stav da Kantovo mišljenje svijeta na koncu i sâmo kapitulira pred konačnošću.
Negativni brojevi i Kantovo predkritičko razumijevanje matematike
Authors: Rujević Goran
Published: January 2025

U ranoj je povijesti matematike moguće pronaći barem tri načina tumačenja negativnih brojeva: (1) odbijajući, u kojem se negativni brojevi smatraju indikatorima greške u zaključivanju; (2) računski, u kojem se negativni brojevi prihvaćaju samo kao apstraktni ra- čunski alati; i (3) fizikalistički, u kojem se negativni brojevi povezuju s konkretnim realnim interpretacijama kao što su suprotstavljene sile. Uspoređivanjem ovih načina tumačenja s idejama koje je Immanuel Kant (1724. – 1804.) iznio u svojem predkritičkom tekstu Pokušaj da se u svjetsku mudrost uvede pojam negativnih veličina (1763.), zaključujemo da je on posve zastupao fizikalističko tumačenje negativnih brojeva. Na temelju ovog uvida možemo pouzdano zaključiti da je Kant u svojem predkritičkom razdoblju baštinio ne samo newtonovsko viđenje prirodnog svijeta nego i newtonovsko shvaćanje matematike.
Dvije dogme kritike obrazovanja
Authors: Krstić Predrag
Published: January 2025

Rad je posvećen statusu i perspektivama kritike u teoriji obrazovanja. Detektirajući da je riječ ili o društvenoj kritici u kojoj se obrazovanje pojavljuje kao zgodan krivac i investicijska moneta, ili o kritici nevelikog zahvata koja korigira didaktičke strategije u unaprijed zadanim okvirima, autor artikulira dva aksiomatska uvjerenja koja onemogućavaju radikalnu kritiku obrazovanja u suvremenosti. Prvo uvjerenje ili prva metodska dogma odnosi se na nužan a neopravdan povlašteni epistemički položaj kritičara koji kritiku čini ili neosnovanom ili, ukoliko je iole teorijski odgovorna, regenerira sistem koji smjera potkopavati. Druga dogma odnosi se na uvjerenje da se obrazovanjem treba postići nešto što nadilazi neposredni djelokrug obrazovanja, nešto što njegova aktualna organizacija ne postiže, a što se nikakvim drugim sredstvima navodno ne može postići. Zaključuje se da ta normativna dimenzija koju društvo nameće obrazovanju može ishodovati pogubnim učincima.
PROTEIN-PROTEIN INTERACTION PREDICTION USING A DEEP NEURAL NETWORK WITH BATCH NORMALIZATION AND QUARTILE ALGORITHM
Authors:   Assistant Professor, Department of Computer Science, Esatic, Cote Divoire., Diffon Charlemagne Kopoin N , Armand Josue Akohoule Alex ,   Assistant Professor, Department of Computer Science, Esatic, Cote Divoire., Morie Wielfrid ,   Assistant Professor, Department of Computer Science, Una, Cote Divoire., Pascal Asseu Olivier ,   Professor, Department of Computer Science, Esatic, Cote dIvoire.
Published: January 2025

Detecting protein-protein interactions (PPIs) is key for disease therapy development. While experimental methods are costly, deep neural network (DNN) models now use available PPI data for prediction, though limited by low-quality sequence-based data. This study introduces FDPPI, a DNN model leveraging a quartile-based algorithm and batch normalization to enhance performance, achieving 98.09% accuracy, 98.34% precision, and 97.72% sensitivity on human PPI data.
PROPUESTA DE INDICADORES PARA EVALUAR EL VALOR ECOLÓGICO DE HUMEDALES COSTEROS DE LIMA Y CALLAO
Authors: Jurado Maura , Tam Jorge , Ramírez Dámaso W.
Published: January 2025

El estado de conservación de un ecosistema puede ser medido mediante su valor ecológico. Como parte de una serie de normas en el marco del Sistema Nacional de Evaluación de Impacto Ambiental, el Ministerio del Ambiente del Perú ha publicado la metodología para calcular el valor ecológico de ecosistemas altoandinos en la “Guía Complementaria para la Compensación Ambiental: Ecosistemas Altoandinos”. En la actualidad existen guías de evaluación del estado de conservación de ciertos tipos de ecosistemas; sin embargo, no se cuenta aún con una guía que defina los indicadores y atributos ecológicos para humedales costeros. El presente estudio propone ocho indicadores considerados como idóneos para calcular el valor ecológico de los humedales costeros del Perú, seleccionados mediante un índice de idoneidad. Como caso de estudio, se calculó el valor ecológico de cuatro humedales de Lima y Callao: Pantanos de Villa, Ventanilla, Santa Rosa y Puerto Viejo, utilizando información de fuentes secundarias y primarias (entrevista a expertos). Considerando a los Pantanos de Villa como el ecosistema de referencia con un valor ecológico “muy bueno”, se encontró que los humedales de Santa Rosa, Ventanilla y Puerto Viejo presentaron un valor ecológico “bueno”. Asimismo, se encontró una correlación positiva, aunque no significativa, entre el valor ecológico y el nivel de gestión ambiental. Los indicadores ecológicos propuestos podrán ser usados para calcular el valor ecológico de otros humedales a lo largo de la costa del Perú y se lograrían aplicar en la elaboración de documentos técnicos o investigaciones sobre el estado de conservación, monitoreo, rehabilitación, restauración o compensación de humedales costeros, contribuyendo a su adecuada gestión y conservación.
Brain-Derived Neurotrophic Factor (BDNF) in Huntington’s Disease: Neurobiology and Therapeutic Potential
Authors: Azman Khairunnuur Fairuz , Zakaria Rahimah
Published: January 2025

Huntington's disease is a hereditary neurodegenerative disorder marked by severe neurodegeneration
in the striatum and cortex. Brain-derived neurotrophic factor (BDNF) is a member of the
neurotrophin family of growth factors. It plays a crucial role in maintaining the survival and proper
function of striatal neurons. Depletion of BDNF has been linked to impairment and death of striatal
neurons, leading to the manifestation of motor, cognitive, and behavioral dysfunctions characteristic of
Huntington's disease. This review highlights the current update on the neurobiology of BDNF in the
pathogenesis of Huntington's disease. The molecular evidence and the affected signaling pathways are
also discussed. In addition, the impact of experimental manipulation of BDNF levels and its pharmaceutical
potential for Huntington's disease treatment are explicitly reviewed.
Co-administration of Naringin and NLRP3 Inhibitor Improves Myelin Repair and Mitigates Oxidative Stress in Cuprizone-Induced Demyelination Model
Authors: Kalaki-Jouybari Fatemeh , Shirzad Moein , Javan Mohammad , Ghasemi-Kasman Maryam , Pouramir Mehdi
Published: January 2025

Background:

Naringin and MCC950 as an inflammasome inhibitor have exhibited numerous
pharmacological activities, including antioxidant and anti-inflammatory effects. The present study
has examined the combined impacts of naringin and MCC950 on the levels of oxidative stress, demyelination,
and inflammation in the cuprizone (CPZ)-induced demyelination model.

Methods:

In order to induce demyelination, CPZ (0.2% w/w) was added to the normal diet of mice for
42 days. Subsequently, the male C57BL/6 mice received naringin (oral administration), MCC950 (intraperitoneal
injection), or their combination for 14 days. Working memory was tested by the Y maze.
FluoroMyelin staining, MOG, and GFAP immunostaining assessed the demyelination extent, myelin
intensity, and astrocyte activation, respectively. Oxidant/antioxidant biomarkers were measured using
colorimetric techniques. The expression levels of MBP, PDGFRα, Olig2, Nrf2, HO-1, NQO-1, GSK3β,
IL1β, and IL18 were assessed by reverse transcription-quantitative polymerase chain reaction
(RT-qPCR).

Results:

Our results indicated that the co-administration of naringin and MCC950 improved working
memory and antioxidant capacity. A significant reduction was found in the extent of demyelination
and inflammatory mediatorsin naringin and MCC950-treated mice. In addition, co-administration of
naringin and MCC950 elevated the expression levels of pro-myelinating and antioxidant markers.

Conclusion:

These findings indicated improvement of the working memory through co-administration
of naringin and MCC950, which might be partly mediated by enhancing antioxidant capacity, promoting
remyelination, and mitigating inflammation in the CPZ-induced demyelination model.
Effect of a Hyperkyphosis-specific Exercise Program on the History of Falls, Fear of Falling and Satisfaction in Older People with Hyperkyphosis: A Pilot Study
Authors: Duangkaew Roongtip , Bettany-Saltikov Josette , Van Schaik Paul , Kandasamy Gok
Published: January 2025

Background:

Hyperkyphosis, an excessive curvature of the upper back, has been linked to increased falls and fear of falling. Previous work has focused on improving the hyperkyphosis curve itself. There is, however, a dearth of studies that have focused on improving falls, fear of falling, and participants’ satisfaction with the educational material.

Objective:

This study aimed to determine the effect of a hyperkyphotic-specific exercise programme on falling, fear of falling, and satisfaction with the educational material.

Methods:

Thirteen individuals with a hyperkyphosis of over 40 degrees were randomly divided into an exercise group (n=6; age: 71.50 ± 7.84 years) and a control group (n=7; age: 67.29 ± 9.76 years). The exercise group received a 16-week hyperkyphosis-specific exercise programme with educational material. The control group received only the educational material. Before and after the exercise programme, the history of falls in the past year and fear of falling were assessed by 2 questionnaires (the history of falls in the past year and the Fall Efficacy Scale-International). Satisfaction with the educational material was evaluated after the exercise programme. Data were analysed by descriptive statistics and a 2×2 model mixed between-within subjects analysis of variance.

Results:

There was no significant interaction between group and time for the history of falls in the past year (p = .182, effect size = .156) and fear of falling (p = .216, effect size = .135), but the effect size of the interaction effect was large. Furthermore, participants in both groups expressed positive satisfaction with the educational material.

Conclusion:

Hyperkyphosis-specific exercise programme resulted in improvement in the history of falls and fear of falling, but the results were not significant. A larger randomised controlled trial is needed to clarify the effectiveness of the exercise programme in reducing the number of falls and fear of falling in this population.
Da vela ao incêndio. Subversões do brincar
Authors: Monteiro Hugo
Published: January 2025

This essay attempts to analyze some aspects of the experience of playing as a subversion of the tra-ditional concepts of “productive activity”, “com-munity”, “time” and “language”. It takes vague and allusive inspiration from the writing of Maria Gabriela Llansol, from her one-off educational project, but also from some fundamental critical moments, where the prominence of playing insti-gates a rethink of the wholeness of the educational experience. The first part looks at how the educa-tional project associated with Llansol takes on an experiential scope, capable of questioning some concepts that are considered insurmountable in the educational lexicon, such as ‘school’, ‘group’ and even ‘childhood’. The second part questions the idea of ‘time’ and the openness to its subver-sion in the experience of ‘play’, in its plurality and scope. From candle to fire is an attempt to take in the extent to which the contained exercise of play expands and potentially spreads to dimensions of social and educational transformation that are considered socially and humanly essential.
Intervenção com crianças nos Açores: um projeto educativo e cultural nos CATL Municipais da Ribeira Grande - A Ponte Norte
Authors: Bulhões Paulo César Fróes
Published: January 2025

In this text we present an educational and cultural project with children living in São Miguel, Azores. In daily life, they are in an institution belonging to the Network of CATL – Centros de Atividades de Tempos Livres – A Ponte Norte – Cooperativa de Ensino e Desenvolvimento da Ribeira Grande, CRL. It is a project involves 350 children (aged 3 to 12) and 35 employees responsible for 17 CATL rooms, distributed among 5 Private Social Solidar-ity Institutions, located in 14 parishes São Miguel – Azores. The main objectives of the project are: i) to promote equal socio-educational opportu-nities; ii) to encourage study, valuing school edu-cation; iii) to create conditions of sociability and cultural exchange that create well-being; iv) to promote recreational practices and cultural enter-tainment; v) to promote activities that recognize local heritage as part of cultural identity. The pro-ject focuses on culture, education, sport and art in order to provide new opportunities, experiences and learning, with a view to the children’s personal and social development and the construction of an Azorean identity.
Enhancing Regional Cooperation for Human Security: Insights from ASEANAPOL's 2023 Committee A
Authors: Rahman Raihanah Dinda Alyfia
Published: January 2025

Integration of human security concepts in the 41st ASEANAPOL Meeting, Committee A focusing on enhancing regional cooperation to address complex global security threats. With analyzes how initiatives within ASEANAPOL aim to protect individuals' well-being from various transnational threats, encompassing aspects like personal protection, health, environment, economic, and community security. By using the theory of liberal institutionalism in viewing the existence of ASEANAPOL, and integrating the results of the Commission A meeting at the 41st ASEANAPOL with the concept of human security. The findings underscore the significance of regional institutional cooperation, particularly through ASEANAPOL, in bolstering human security for citizens of member countries and combating transnational crimes effectively. Through discussions on transnational crimes like drugs trafficking, terrorism, arms smuggling, trafficking in persons, and wildlife crimes, the outcomes of the 41st ASEANAPOL Meeting, which include the establishment of specialized task forces and enhanced information sharing, the study underscores the commitment of member countries to enhance collaboration enforcement capacities. the journal emphasizes the importance of human security from diverse transnational threats in the Southeast Asian region.
Ocupación de Familia: Parent-Child Stress and Coping in Rural Farm-Dependent Families
Authors: Keeney Annie J. , Rodriguez Anabel , Murillo Jaime , Ingold Savannah S.
Published: January 2025

Farmworkers are the backbone of the agricultural economy in the US yet are disproportionately burdened with economic-related stress and adverse behavioral health outcomes. How these stressors translate to children and family well-being is poorly understood. Grounded in Transactional Stress and Coping Theory, we aimed to understand how children and families adapt and respond to the stressors associated with farm labor occupations in a rural, underserved, bi-national community. We utilized focus groups with adult children of farmworkers and behavioral health providers serving the farming community to understand the lived experiences of growing up with a farmworker parent. Findings suggest that farm-dependent families face chronic, interconnected stressors. Farm work is viewed as a family occupation where each member contributes directly or indirectly to the farm labor efforts. Distinct coping strategies were used among parents and children. To effectively support farm-dependent families, we recommend prioritizing K-12 policy and programming specific to farmworker families, reducing farmworker's exposure to precarious employment conditions, and employing universal harm reduction strategies to address substance use.
Review of the Quality and Reliability of Online Arabic Content on Diabetic Retinopathy: ‏An Infodemiological Study (Preprint)
Authors: Alabdrabulridha Abdullah Ahmed , Alabdulmohsen Dalal Mahmoud , AlNajjar Maryam Abdullah , Algouf Ibtisam Ahmed , Al-Omair Abdullah Mohammed , Alyahya Omaima Muneer , Almahmudi Mesa Ahmed , Al Taisan Abdulaziz Ahmed
Published: January 2025

BACKGROUND

Diabetic retinopathy (DR) is a leading cause of vision loss, particularly in the Middle East. With the rise of online health information, many patients turn to the internet for knowledge about health conditions. However, the accuracy and quality of this information can be questionable, particularly in languages other than English.

OBJECTIVE

We sought to evaluate the quality and reliability of Arabic websites on DR to address this knowledge gap and improve patient care.

METHODS

The first 100 Arabic search results for DR were examined on Google.com, focusing on patient education websites in Arabic. Content was assessed using a 20-question model, quality was evaluated with the Discern instrument, and reliability was measured by the JAMA benchmark. Two independent raters conducted evaluations, and data were analyzed with SPSS. Descriptive statistics were used for website characteristics, and the first ten Google webpages were compared to others using bivariate analysis with a significance level of p<0.05.

RESULTS

A Google search yielded 178,000 websites; the first 100 were examined, with 29 meeting inclusion criteria. Most were hospital or medical center sites (n = 20, 69%). The DISCERN assessment showed a low mean score of 36.59 ± 9.32 out of 80 points, with most rated "poor" or "very poor." The JAMA benchmarks indicated low reliability, with 62% failing to meet any criteria.

CONCLUSIONS

This study identified significant failings in the content, quality, and reliability of Arabic websites on diabetic retinopathy, highlighting the need for stronger evidence-based online resources focused on early disease prevention.
Study on Removal Methods of Heavy Metals from Marine Freshwater Products
Authors: Junhao Chen , Guiqing Chen
Published: January 2025

Nowadays, Marine rivers are seriously polluted, and heavy metals such as arsenic, cadmium, mercury, lead, chromium and copper are absorbed by Marine freshwater organisms, seriously endangering human health. After boiling Marine river products such as scallop skirt into a concentrated liquid and adding sodium carbonate Na2CO3, most heavy metals will precipitate under strong alkaline conditions and be removed by filtration. But it doesn't work on tin Sn. Adding calcium hydroxide Ca(OH)2, the heavy metal forms a precipitate under strong alkaline conditions. It’s filtered out. Citric acid or calcium citrate are strong chelating agents that can form chelating precipitates with heavy metals and be removed by filtration. The combination of the above two is better. Filtration loss can be reduced if hydrolysis is performed first!
STUDY OF FRICTION COMPENSATION MODEL FOR MOBILE ROBOT’S JOINTS
Authors: Cao Yanjie , Mohamad Nor Norzalilah , Samad Zahurin
Published: January 2025

Frictional forces inside the joints of mobile robots hurt robot operation's stability and positioning accuracy. Therefore, establishing a suitable friction force compensation model has been a hot research topic in robotics. To explore the robot joint friction compensation model, three friction compensation models: linear, nonlinear, and neural network models, are developed in this paper. Based on the deep learning algorithm for three models at low speed, high speed, acceleration, and uniform speed training test, respectively results have been obtained. The test results show that the best friction compensation effect comes from combining neural network models in acceleration and a consistent speed state way. The friction compensation model trained this way yielded superior results to the other combinations tested. Finally, using the method, a friction compensation model trained by adding a neural network to the feedforward control torque was tested on a four-wheeled mobile robot platform. The test results show that the relative error of the torque caused by the friction of each joint is reduced by 15%-75% in 8 groups of tests, which indicates that our friction compensation method has a positive effect on improving the accuracy of the joint torque.
DYNAMIC STABILITY ANALYSIS OF A COUPLED MOVING BOGIE SYSTEM
Authors: Stojanović Vladimir , Dimitrov Lubomir , Tomov Pancho , Li Deli , Nikolić Vlastimir
Published: January 2025

This study explores the dynamic behavior and vibration stability of a complex moving mechanical oscillator coupled with a three-part viscoelastically connected continuous beam-foundation system. Elastic waves generated by the oscillator can destabilize the system, a scenario common in high-speed trains and vehicles. The paper presents an improved analytical approach, focusing on the effects of a variable primary stiffness suspension on vibration stability. Using the D-decomposition method and the principle of the argument, instability intervals are determined for varying stiffness configurations, highlighting the benefits of nontraditional suspension systems in improving local stability.
MicroRNAs en las Ciencias Médicas: Un avance hacia la precisión clínica merecedor del premio Nobel
Authors: Mendoza-Soto Ana Belén , Aviña-Padilla Katia
Published: January 2025

El descubrimiento de los microRNAs (miRNAs) ha revolucionado la biomedicina moderna. Estas pequeñas moléculas de RNA, de 18-24 nucleótidos, son reguladores clave de la expresión génica, actuando como "interruptores" que controlan la activación o silenciamiento de genes en momentos críticos. Su impacto en la comprensión de procesos celulares y enfermedades ha sido reconocido con el Premio Nobel de Medicina. Los miRNAs se han convertido en herramientas prometedoras en el diagnóstico y tratamiento de enfermedades complejas como el Alzheimer, la diabetes mellitus tipo 2 (DM2), y las enfermedades cardiovasculares, consolidándose como un pilar en la medicina de precisión.
Localización radiográfica del canal mandibular en una población mexicana, periodo 2019-2021
Authors: Contreras Carlos , Carrera Grecia , Rincón Fernando , Sosa Darío
Published: January 2025

Introducción: el canal mandibular es un detalle anatómico que debe tomarse encuentra al realizar ciertos procedimientos en cirugía bucomaxilofacial. La ortopantomografía es un medio diagnóstico común utilizado en la práctica odontológica. Se han realizado investigaciones de este tipo en distintos países sobre el canal mandibular y su relación con otros reparos anatómicos mandibulares; sin embargo, no hay reportes en poblaciones mexicanas. Objetivo: determinar localización del conducto mandibular en una población mexicana mediante ortopantomografías. Materiales y métodos: estudio transeccional descriptivo. La muestra estuvo constituida por 270 ortopantomografías obtenidas de un centro radiológico privado en nuevo león, México, durante el periodo 2019-2021. Los datos fueron analizados mediante estadística descriptiva e inferencial mediante el paquete estadístico SPSS v.15. Resultados: se obtuvieron diferencias estadísticamente significativas en las medidas entre lado derecho y lado izquierdo, sexo y algunos grupos etarios. Conclusión: existen diferencias significativas en las distancias entre la basal mandibular y la distancia vertical, comprendiendo los molares con respecto al canal mandibular, entre individuos de ambos sexos y con énfasis en la tercera y sexta década de la vida. La importancia del correcto diagnóstico a través de la ortopantomografía permite al clínico evitar lesionar estructuras nobles mandibulares.
Seguridad y protección radiológica con el uso de rayos X portátiles. Revisión de literatura
Authors: Marichi-Rodríguez Francisco Javier , Serrano-Bello Janeth , Ortiz-Magdaleno Marine , Vázquez-Vázquez Febe Carolina
Published: January 2025

Introducción: los equipos de rayos X portátiles ofrecen varios beneficios para el operador. Sin embargo, la seguridad y protección para el operador y el paciente durante la toma de radiografías dentales intraorales es prioridad. Objetivo: sintetizar los hallazgos existentes del estado del arte, de la información y los datos publicados por artículos científicos acerca de la seguridad y protección en el uso de rayos X portátiles en odontología. Material y métodos: se llevó a cabo una revisión del estado del arte referente a la información y los datos publicados por artículos científicos acerca de la seguridad y protección en el uso de rayos X portátiles en odontología. La búsqueda de información se realizó en las bases de datos PubMed, Scopus y Web of Science. Resultados: los equipos de rayos X portátiles no suplirán completamente a los equipos fijos y móviles. Sus dimensiones pequeñas, su facilidad de operar y las imágenes radiológicas con la misma calidad que un equipo fijo son algunas de las ventajas que ofrecen. La dosis de radiación ionizante generada por el equipo portátil es inferior a 0.6 mSv y⁻¹; por lo tanto, cumple con las normas de seguridad y protección. Estudios recomiendan que el uso de equipos portátiles esté siempre justificado ante el uso de un equipo fijo, y revisar que el equipo portátil esté certificado por la Food and Drug Administration (FDA). Es imperativo que el operador esté capacitado para el uso del equipo portátil, que conozca su funcionamiento, utilice chaleco, guantes y lentes de protección. Conclusión: los equipos portátiles de rayos X son una alternativa al uso de equipos fijos y móviles, debido a que la radiación a la que está expuesto el operador es menor a la dosis límite permitida. Es necesario mantener el control estricto del área de trabajo, asegurar el uso y el funcionamiento correcto del equipo.
Inherently Non-Pulsating Input Current DC-DC Converter for Battery Storage Systems
Authors: P Rasnas
Published: January 2025

With an ever-growing number of batteries being integrated into the electric grid, bidirectional converters with nonpulsating dc input current are required to replace the existing bidirectional converters so as to extend the lifetime of such dc
power suppliers. Bidirectional DC-DC converters are increasingly used in a variety of applications including uninterruptable
power supplies, electric vehicles and renewable energy systems. In this study, we propose a new topology of bidirectional dc-dc
converter with inherently no pulsating input current (NPIC), which is intended to be used for battery energy storage systems.
With simple modifications from the conventional converters, the proposed NPIC converter has no inherent pulsating input
current in the step-down (buck) mode. Whereas in the step-up (boost) mode; the proposed NPIC converter retains the desired
voltage gain. Underpinning theories, operating principles and steady-state performances are analyzed and presented in detail,
which are then corroborated by simulation and experimentation. The proposed converter topology, with simple design principle
and ease for implementation, is likely to have wide-ranging applicability in interfacing electrochemically functioned dc sources
to modern power systems
A Review on “Chromatography: A Versatile Tool in Pharmaceutical Analysis and Allied Industries"
Authors: Ade Rohit Pradip
Published: January 2025

In pharmaceutical analysis, chromatography is a crucial analytical method that is extensively utilized to separate,
determine, and measure the components of complicated mixtures. An outline of the basic ideas, historical evolution, and diverse
uses of chromatography in the pharmaceutical and related sectors is given in this review. Chromatography, which began with
Tswett's groundbreaking discovery in 1906, has developed into a flexible technique that uses both stationary and mobile phases
for separation. The mechanics, guiding principles, and unique uses of techniques such as Gas Chromatography (GC), Liquid
Chromatography (LC), (TLC), (HPLC), and High-Performance Thin Layer Chromatography (HPTLC) are thoroughly
examined. The review explores the importance of immiscible phases in accomplishing selective molecule separation as well as
partition and adsorption as the main separation methods.
Applications cover a extensive range of domains, including as food safety, forensic science, environmental monitoring, quality
control, and drug development. Chromatographic techniques have become essential for evaluating the purity of pharmaceutical
products, guaranteeing their safety, and complying with regulatory requirements thanks to the integration of technological
breakthroughs. The diversity of chromatography and its vital function in analytical research and industry are highlighted by this
thorough study.
Experiencias Formativas Profesionalizantes del Prácticum: Un Análisis reflexivo desde las Voces de sus Protagonistas.
Authors: Haas Valentina
Published: January 2025

Este trabajo revisa el libro El e-diario de los actores del prácticum y prácticas externas, coordinado por las Dras. Ana María Martín-Cuadrado y Lourdes Pérez-Sánchez. La obra ofrece una valiosa aportación al campo de la formación profesional, destacando el uso del e-diario como herramienta clave para la reflexión y el aprendizaje en las prácticas profesionales. A través de una investigación colaborativa, se exploran las perspectivas de estudiantes y tutores, subrayando los desafíos y oportunidades que ofrecen las tecnologías digitales en la formación.
SCREENING INSTRUMENT FOR ZAKAH CAPITAL ASSISTANCE EGIBILITY
Authors: Harun Noor Fazni , Rahman Asmak Ab
Published: January 2025

This study aims to determine the need for a viable and comprehensive screening instrument for selecting those individuals eligible for receiving financial assistance from zakah institutions in Malaysia. The study uses qualitative research methods and collects primary data with the help of semi-structured interviews with five zakah institutions in Malaysia. Complete consensus was found among all respondents on the need for a viable and comprehensive instrument to screen prospective zakah business recipients. The screening instrument will facilitate the evaluation process to determine eligibility on the basis of pre-formulated criteria and minimize manipulation and fraud. The study recommends that zakah authorities should have a screening instrument to select zakah recipients eligible for capital assistance.
HOUSEHOLDS’ OVER-INDEBTEDNESS: AN EXPLANATION FROM A SHARI‘AH PERSPECTIVE
Authors: Ghaouri Mohamed Hamza , Kassim Salina , Zakariyah Habeebullah , Othman Anwar Hasan Abdullah
Published: January 2025

Excessive indebtedness at the individual level can create vulnerability to exploitation (Zulm), leading to a modern form of slavery known as debt bondage. Household over-indebtedness has become an increasingly widespread phenomenon in Malaysia, compounded by the negative economic impact of the COVID-19 pandemic. In response, this study explores the different aspects of indebtedness from a Sharī‘ah perspective. The research draws on a qualitative methodology, including an intensive literature review, analysis of Quranic verses and the sayings of the Prophet. (pbuh), as well as interviews with reputable scholars. The study provides a detailed understanding of Sharī‘ah's position on debt in various circumstances, the relationship between debtors and creditors, preventive solutions, and solutions for those over-indebted. The study highlights rules that regulate the relationship between debtors and creditors and suggests solutions to assist households in financial difficulties. The study concludes that incurring debt should be for Sharī‘ah-compliant purposes and with a genuine intention to pay back, regardless of the hierarchy of needs. This study makes a valuable contribution to the literature on preventing debt bondage and offers insights that can help households avoid over-indebtedness.
HEALTHCARE WAQF AND SOCIO-ECONOMIC DEVELOPMENT IN INDONESIA: CASE STUDY OF HOSPITAL ROEMANI MUHAMMADIYAH
Authors: Rahmanto Mukhlis , Rahman Asmak Ab , Daud Zaidi Mohd
Published: January 2025

The article describes a waqf-based hospital in Indonesia to show continuity and change in the development of waqf-based Islamic hospitals, which began in the Prophetic era and has survived until today. The findings show there are several transformations from waqf-based hospitals in medieval and early modern Islam where many of the founders, from the Sultan and the elites of the Islamic dynasty to the donors, come from the civil and private sector, for instance, Ḥājj Roemani, the founder of Hospital Roemani Muhammadiyah, an entrepreneur with the same background as Hakim Muhammad Said of Hamdard Pakistan. Also, there is a shift from what is called "free healthcare service to the needy and poor", which is generally understood as fully free, to the several features of changes ranging from a very nominal charge, reduction of the cost, and health insurance with low premiums subsidized by the state for the needy and poor. The shifting influence of the hospital management model towards a commercial, even though the hospital itself is waqf based, whose essential character is non-profit. We argue this is due to the human population growth and the challenges of the emergence of various diseases until the pandemic, increasing the need for health funds. Hence, the hybrid scheme of Islamic philanthropy funds is needed and can make this hospital an institution that not only plays a role in the socio-economic development in the health sector but extends to other socio-economic sectors.
[in]visible time
Authors: Margarida Dias  , Cristina Ferreira  , Maria Lurdes Gomes  , Catarina Casais
Published: January 2025

Stages, thoughts and results about the i2ADS project "[in]visible - [in]visibility of identities in Portuguese 1st grade elementary textbooks of Social & Environmental Studies after 1974" (DOI 10.54499/2022.05056.PTDC), funded by FCT - Fundação para a Ciência e Tecnologia.
+ info at https://invisible.i2ads.up.pt/en/intru/
Pengintegrasian Learning Management System (LSM) dengan Artificial Intelligence untuk Memfasilitasi Ragam Kebutuhan Peserta Didik
Authors: Nuzulia Rizkika Wahyudanti  , Syifa Nathania Rahmadanti  , Nila Khimaya
Published: January 2025

Keberagaman sosial-budaya yang dimiliki Indonesia menjadi salah satu faktor eksternal perbedaan gaya belajar pada setiap individu. Perbedaan tersebut mampu mempengaruhi pencapaian akademis siswa. Pendidikan Indonesia belum mampu memenuhi kebutuhan akademis individual tiap siswa. Usaha-usaha untuk mengidentifikasi kebutuhan belajar tiap siswa telah banyak dilakukan oleh satuan pendidikan. Namun, dengan karakteristik kelas di satuan pendidikan Indonesia yang cenderung ramai, sulit bagi guru untuk memperhatikan kebutuhan tiap murid secara personal. Dalam pembelajaran konvensional, guru tidak bisa memfasilitasi semua gaya belajar secara bersamaan. Sehingga, dewasa ini proses pendidikan semakin mengedepankan proses pembelajaran yang berpusat pada siswa atau student-centered learning. Karakteristik dari student-centered learning adalah fleksibilitas pembelajaran dalam menyesuaikan kecepatan dan gaya belajar masing- masing siswa. Learning Management System (LMS) menjadi salah satu media pembelajaran yang diciptakan untuk mendukung pelaksanaan daring saat pandemi beberapa waktu lalu. Namun, laman Learning Management System tidak lagi digunakan ketika pandemi telah usai dan kegiatan pembelajaran kembali dilaksanakan secara luring. Padahal, LMS dapat tetap digunakan untuk mendukung pelaksanaan kegiatan pembelajaran sehingga dapat memudahkan siswa maupun guru. Utamanya, laman Learning Management System dapat digunakan sebagai arsip materi dan tugas-tugas yang dapat diakses oleh siswa dengan mudah. Fungsi LMS dapat dioptimalkan dengan teknologi Artificial Intelligence (AI) atau kecerdasan buatan. Teknologi AI pada laman Learning Management System dapat digunakan untuk memenuhi ragam kebutuhan gaya belajar siswa. Topik ini akan diteliti menggunakan metode literature review. Ditemukan bahwa Learning Management System berbasis AI mampu memfasilitasi pencapaian akademis siswa dan membantu guru dalam proses pembelajaran.
Strategi Pemasaran Es Coklat (Studi Kasus Es Coklat Celup di Kartasura, Sukoharjo)
Authors: Rima Dwi Safitri  , Rifdah Safinatun Najah  , Sri Nur Khoiriyah
Published: January 2025

Strategi pemasaran adalah upaya memasarkan suatu produk, baik itu barang atau jasa dengan menggunakan pola rencana dan taktik tertentu sehingga jumlah penjualan menjadi lebih tinggi. Industri kecil merupakan bagian penting dari sistem perekonomian nasional, karena dapat mempercepat pemerataan pertumbuhan ekonomi melalui misi penyediaan lapangan usaha dan lapangan kerja. Penelitian ini menggunakan pendekatan kualitatif deskriptif. Data yang digunakan data primer berupa observasi, wawancara dan dokumentasi. Strategi pemasaran dengan menggunakan bauran pemasaran 4P (produk, harga, lokasi dan promosi), sedangkan analisis data dari hasil bauran pemasaran menggunakan analisis SWOT (kekuatan, kelemahan, peluang dan ancaman). Sampel dalam penelitian ini yaitu pegawai dan konsumen Es Coklat Celup di Kartasura, Sukoharjo. Tujuan penelitian ini yaitu menganalisis dan mendeskripsikan strategi pemasaran Es Coklat Celup di Kartasura, Sukoharjo.
THE EFFECTS OF THE EURO’S DECLINE ONTHE ALBANIANECONOMY
Authors: Gogo Gerta
Published: January 2025

Aim: This study aims to analyze in detail the sectors that have suffered from the euro’s fall and evaluate their situation in the Albanian economy. This article investigates the impact of the euro’s devaluation on the primary economic sectors, including imports and exports. Since the clothing sector was among the most im­pacted by this drop, particular attention has been paid to the export of leather and its products, as well as the textile and footwear sectors. Methods: The data used in the analysis were sourced from the primary institute that published the data. These institutions, which are in charge of collecting and releasing accurate and reli­able economic data, include the Institute of Statistics and the Bank of Albania. Data analysis was done using descriptive analysis. This analytical technique was used to draw attention to the shifts and effects that the exchange rate transactions had over the time under study. As a result, now we have the chance to comprehend how and why these developments have affected the Albanian economy. Results: The results in this study allow us to see how changes in exchange rates have affected the main sectors of the economy. Since import, export, and tourism are the industries with the highest income in euros rather than the native currency, they have seen the largest impact. Conclusions: Despite the measures taken by the main institutions, these meas­ures didn’t have the expected impact. What these businesses should do to protect themselves from the fall of the euro is to either make contracts in the national currency or use forward contracts for the sale and purchase of euros at the euro rate when the initial contract was concluded.
Deep Learning Training Data for Phase Unwrapping of SAR Interferograms
Authors: Baek Won-Kyung , Jung Hyung-Sup
Published: January 2025

Phase unwrapping is an essential process in synthetic aperture radar interferometry that restores phase signals constrained within the range of (-π, π) to their true phase values. Traditional algorithm-based methods can introduce significant errors due to rapid and steep phase gradient or noise, which negatively impact terrain elevation and surface displacement analyses. To overcome these limitations, deep learningbased phase unwrapping techniques have been proposed; however, there has been insufficient previous studies due to the lack of accurate training and test data. This paper aims to share the training data generated using the phase unwrapping simulation method with locally-different phase noise. The data were generated by the simulation of topographic phases and phase noise, atmospheric and orbital distortions. Additionally, data augmentation for phase variation and noise levels was applied to address data imbalance issues. The shared data consists of two types: one with a constant phase noise level for each patch, and another that simulates locally different phase noise based on augmented coherence data. This data is primarily effective for unwrapping topographic phase components and holds significance as the first phase unwrapping training data of synthetic aperture radar interferograms shared in Korea. We expect this resource to serve as foundational data for future phase unwrapping technology research, including applications for upcoming satellites like KOMPSAT-6 and water resource satellites.