bluuebunny/crossref_metadata_2025 huggingface dataset:
Besiddet, strukturel eller post-strukturel?
Authors: Christensen Gerd
Published: November 2023

I daglig tale benytter vi ofte begrebet ‘magt’ som om det havde en stabil og uforanderlig betydning, som alle forstår og er enige om. Men på mange måder kan det hævdes, at begrebet er det, man med Laclau og Mouffe kan kalde ‘en flydende betegner’: Et begreb, der har ændret betydning over tid og som i dag benyttes med flere betydninger. I daglig omgang giver det sjældent anledning til problemer. Men anderledes forholder det sig, når begrebet indgår i akademisk arbejde, hvor præcise begrebsdefinitioner og -anvendelser er væsentlige. Ofte anvendes ‘magt’ således som en analytisk kategori, hvilket understreger betydningen af en præcis definition og konsekvent brug. Dertil kommer, at forskellige forståelser af ‘magt’ rummer forskellige analytiske (og praktiske) potentialer, hvilket vil sige, at den valgte definition har afgørende betydning for, hvilke konklusioner, der kan drages – i teori og i praksis.

I artiklen vil tre forskellige forståelser af ‘magt’, der er i spil i humanistisk og sam- fundsvidenskabelig forskning, blive diskuteret. Dette vil ske med udgangspunkt i repræsentanter for tilgangene, samt i eksempler på, hvad de forskellige tilgange kan bidrage med som analytiske kategorier og som tilgange til forståelser af praksis.
Perturbations extrêmes sur la dérive
de mortalité anticipée -
Application à un régime de rentes
Authors: Planchet Frédéric , Juillard Marc , Thérond Pierre-E.
Published: November 2023

L’objectif de ce travail est de proposer un modèle réaliste et opérationnel pour mesurer
le risque systématique associé à la construction de tables de mortalité prospectives.
Une application du modèle à l’évaluation de l’engagement d’un engagement
de retraite est proposée. Le modèle présenté est construit sur la base d’un modèle
de Lee-Carter. Les tables prospectives stochastiques sont obtenues en modélisant
l’incertitude attachée au paramètre de tendance du modèle.
La réforme de l’assurance santé américaine
Authors: Moreau Rémi
Published: November 2023

L’auteur décrit la nouvelle réforme sur l’assurance santé aux États-Unis, complètement remaniée au coût de 2,5 trilliards de dollars après de multiples tentatives à cet effet depuis quatre décennies. Après une bataille législative acharnée depuis novembre 2009 jusqu’en mars 2010 entre les Démocrates et les Républicains du Sénat et de la Chambre des représentants, le Président a officiellement promulgué une réforme qui vise à procurer une couverture d’assurance maladie à 32 millions d’Américains qui n’en disposent pas à l’heure actuelle et qui interdit certaines pratiques d’assurance visant à refuser d’assurer des personnes en raison de leur état de santé.
Le lien entre les systèmes d’information et la structure de l’organisation : choix et risques
Authors: Aubert Benoit
Published: November 2023

Pour être performantes, les organisations doivent configurer adéquatement leur différentes composantes; stratégie, structure et technologies de l’information. La
recherche suggère qu’il n’y a pas de configuration organisationnelle systématiquement supérieure. C’est beaucoup plus par la qualité de l’agencement de ces pièces que par le choix absolu d’une forme de structure proprement dite que l’organisation
deviendra performante. Ces choix sont empreints de risques, que ce soit dans le choix même d’une configuration ou dans le projet qui permet de transformer l’organisation.
Les risques sont omniprésents. Le texte présente les questions de structure de la fonction systèmes d’information (impartition et gestion des risques). Par la suite, les transformations des structures de l’organisation rendues possibles par les technologies de l’information sont présentées. Ces changements sont associés de près à la gestion des risques des projets informatiques. Il est important de bien comprendre comment déployer ces technologies si on veut tirer avantage des nouvelles
formes d’organisation.
Crédibilité linéaire bivariée utilisant le nombre de périodes avec réclamations : modèles de Poisson, modèles à barrière et modèles gonflés à zéro
Authors: Boucher Jean-Philippe , Denuit Michel
Published: November 2023

Dans certaines situations, il est bien connu que la crédibilité linéaire univariée est trop restrictive et ne modélise pas bien les primes prédictives. Récemment, Boucher, Denuit et Guillén (2006a, 2006b) ont proposé diverses généralisations du modèle de
Poisson gonflé à zéro et du modèle à barrière. Pour ces modèles, les auteurs ont montré que la distribution prédictive du nombre de réclamations annuelles ne dépend pas seulement du nombre de réclamations passées, mais aussi du nombre de périodes
au cours desquelles l’assuré a fait une réclamation. Nous utilisons la théorie de la crédibilité bivariée afin d’estimer la prime future en fonction de plusieurs prédicteurs afin de comparer l’ajustement des primes de crédibilité linéaire bivariées aux
primes exactes des nouveaux modèles. Nous montrons que l’ajustement pour les modèles gonflés à zéro est satisfaisant alors que celui des modèles à barrière génère des erreurs d’approximation majeures, probablement dues au fait que le modèle de
crédibilité linéaire classique néglige la dépendance des effets aléatoires.
Les titres adossés à des créances hypothécaires : caractéristiques et propriétés
Authors: Boyer Martin , Girard François
Published: November 2023

Le marché des titres adossés à des créances hypothécaires au Canada est un marché qui est à la fois mature et en développement. Bien que les contrats hypothécaires ne représentent rien de nouveau, la vague de titrisation des créances au cours des années 80 a fait en sorte que ces titres financiers sont devenus négociables et largement liquides. Notre article se penche sur une analyse comparative du marché canadien vis-à-vis du marché américain afin d’en comprendre les différences. La compréhension du fonctionnement du marché des créances hypothécaires est essentielle pour comprendre la crise des hypothèques à haut risque qui a fait rage à la fin de l’année 2007.
A New Ridgely-Nevitt Regression-Based Computational Tool for Resistance and Power Predictions for Trawlers
Authors: Xhaferaj Blenard
Published: November 2023

This paper aims to present the architecture and the prediction accuracy of a new computational procedure of the “Ship Power V 1.0” software based on the Ridgely–Nevitt regression, applied to hull resistance predictions for Ridgely-Nevitt series trawlers. The Ridgely-Nevitt series is an important series of trawlers developed by and tested at the Webb Institute. Experimental resistance data have also been presented in the form of a regression model used to develop a new procedure of the “Ship Power V 1.0” software. Furthermore, this new procedure was completely harmonized with other software procedures based on the Holtrop and Van Oortmerssen evaluation methods. Although the mathematical formulation of the Ridgely-Nevitt regression model allows the assessment of the residual resistance coefficient of only nine values from the speed-length ratio, the implementation of an interpolation procedure made possible resistance predictions for any speeds from the acceptable speed-length ratio range. Resistance prediction accuracy improvement introduced by the new procedure was proven by the validation of calculation results not only against experimental data but also against the prediction results of other software procedures for three hulls from the Ridgely-Nevitt fishing vessel series. MAPE (mean absolute percentage error) values calculated against experimental data for the analyzed models were 3.26, 1.71, and 3.36, respectively. Prediction result  comparisons of the Ridgely-Nevitt regression-based “Ship Power V 1.0” computational procedure and the experimental data and predictions of other computational procedures performed on three hulls from the Ridgely-Nevitt series have shown a substantial improvement in prediction accuracy.
Evaluation of the Qualification of Dynamic Positioning Operators Using Analytic Hierarchy Process
Authors: Sahin Tugfan , Bolat Pelin
Published: November 2023

Offshore vessel operations are always important for the industry as the consequences of incidents related to dynamic positioning systems may affect people, cargo, vessels, and the environment. The aim of this paper is to determine the qualification factors and improve the competency standards of Dynamic Positioning Operators (DPOs). The Analytic Hierarchy Process method has been used for this study by processing expert views of senior operators who have at least fifteen years of dynamic positioning experience. The results show that quality of trainer, importance of sea time collected after achieving a full DPO certificate, experience with different types of DP systems, and practical knowledge are defined as the most important factors to becoming a qualified dynamic positioning operator. Besides, situational awareness of DP operators is considered another important factor to reduce possible dynamic positioning incidents. In conclusion, this study provides the following recommendations: promote incentive programmes in order to appeal to  potential trainers, increase the length of minimum required sea time after a simulator course, increase the required practical time onboard in lieu of transferring excessive active sea time to further stages, companies to provide familiarisation courses for operators regarding the equipment onboard prior to joining the vessel for the first time, and promote online training programmes to improve the situational awareness of operators. By using these recommendations, there is a possibility to improve the qualification of DP operators and reduce incidents related to dynamic positioning operations. Last but not least, this research can also be used as a reference in the offshore industry for the training of Dynamic Positioning Operators (DPOs).
Systemic diseases with cutaneous expression and HIV infection in dark skin: Epidemiological and therapeutic aspects in Abidjan (Ivory Coast)
Authors: Kourouma Sarah Hamdan , Gbandama Koffi Kouamé Pacôme , Kouassi Yao Isidore , Allou Ange-Sylvain , Amani Kaunan Leslie-Wilfried Gbonangbo , Kouassi Kouamé Alexandre , Kouamé Kanga , Kaloga Mamadou , Ahogo Kouadio Célestin , Ecra Elidjé Joseph , Gbery Ildevert Patrice , Sangaré Abdoulaye
Published: November 2023

Objective: The objective of the study was to describe the epidemiological, clinical, therapeutic and evolutionary aspects of systemic diseases (SD) with cutaneous expression associated with HIV infection and to identify the circumstances of their occurrence. Patients and methods: This were a cross-sectional, descriptive, and analytical study of the records of patients hospitalized or followed up at the Voluntary Counselling and Testing Unit (VCT) of the Dermatology Department of the University Hospital of Treichville, from January 2005 to December 2014. Results: We recorded 63 patients with MS during this period, 13 of whom were HIV positive (20.6%). MS of HIV positive patient was more frequent after 24 years (mean age: 49.5 years) and a male predominance (58.3%). HIV 1 was involved in all cases with a mean CD4 count of 190/mm3 [18-521] at diagnosis of MS. HIV-associated MS were psoriasis (7 cases), cutaneous lymphoma (2 cases), Goujerot-Sjögren syndrome (1 case), pyoderma gangrenosum (1 case), systemic scleroderma (1 case) and sarcoidosis (1 case). They were circumstances of discovery of HIV infection in 7 cases, expression of therapeutic failure in 3 cases and expression of an immune restoration syndrome in 3 cases. The 13 patients received concomitant antiretroviral treatment and the specific treatment of the systemic pathology associated with an anti-inflammatory in some cases. Conclusion: The association of MS and HIV infection is rare. Their etiologies are dominated by psoriasis in Abidjan. A well-conducted interrogation to determine the chronology of events, assisted by biological examinations, allows the circumstance of occurrence to be identified.
Some of the Issues of Preventing Offenses Involving Child Passengers
Authors: Afonin Vadim Vyacheslavovich
Published: November 2023

The subject of the study is the administrative and legal norms regulating the basic rules of transportation of children in a car. The object of the study is public relations in the field of prevention of children's road traffic injuries. The purpose of the work was to analyze the current requirements and regulations in the field of transportation of children in a passenger car, identify current problems arising in this area and suggest ways to solve them. Methodological basis of the work: fundamental postulates of the theory of law; generalization of practical experience, application of methods of logical, monographic and system analysis. The author examines in detail such aspects of the topic as preserving the life and health of children-road users, reducing the level of road accidents involving them, as well as minimizing the severity of their consequences. Scope of application of the results: the provisions of the work can be used in the legislative activity of state bodies, law enforcement practice of state bodies directly engaged in the prevention of child traffic injuries, the educational process with any category of children and parents, scientific research of administrative scientists investigating issues of road safety. The novelty of the work is determined by the practical and scientific significance of the problems of law enforcement practice of state bodies involved in the prevention of child traffic injuries, as well as the need to improve the legal framework governing the powers of internal affairs bodies. The author proposes a comprehensive approach to solving this problem, starting with proposals to improve the complex of preventive measures aimed at reducing the number of road accidents involving child passengers and the severity of their consequences and ending with the author's proposal to improve the current administrative legislation in the field of road safety.
Labor adaptation and vocational training as areas of social support for participants in a special military operation
Authors: Girfanova Arina Radikovna
Published: November 2023

The author consider aspects of measures of social support for combat invalids in the context of participation of citizens of the Russian Federation in a special military operation. The study pays special attention to the legal status of state civil servants of the Russian Federation who took part in a special military operation as part of conscription for military service on mobilization, as well as participation in volunteer formations. The author examines the novelties of domestic legal regulation in this and related fields. A number of scientific papers are also being considered, within the framework of which the effect of attracting veterans to civil service abroad is being investigated. Using comparative legal and formal legal methods, the author establishes the framework of current regulation and determines possible prospects for its development. Based on the conducted research, the author concludes that there is a need for an integrated approach to the labor adaptation of combat invalids and taking into account their merits and individual characteristics when forming the personnel of the public administration system in the Russian Federation. This article serves as a starting point for starting work on the study of the main areas of improvement of legal regulation in terms of determining the requirements and procedures of the mechanism for selecting the optimal position in order to maintain a balance between the public interests of society and the private interests of the employee.
The main problems of state management of forced migration in Russia: administrative and legal aspect
Authors: Petrovskaya Miroslava Ivanovna
Published: November 2023

The object of this work is the social relations developing in the field of forced migration. The subject of this work is social relations formed in connection with the implementation of public administration in the field of forced migration. The purpose of the work is to develop proposals and recommendations for improving the current legislation in the field of forced migration The methodology of the work is determined by the specifics of the issues under consideration. The methods of analysis and synthesis were used in the analysis of state-legal and social phenomena in the field of forced migration, statistical methods for establishing patterns and analyzing the dynamics of the development of state-legal institutions over time, deduction and induction, as well as formal legal methods in the formulation of conclusions and proposals. The main aim of the study is to identify the basic problems of public administration in the field of forced migration associated with the lack of signs of consistency in the activities of state bodies in the field of forced migration. In particular, this is manifested in the insufficient implementation of the functions of adaptation and integration of forced migrants. Attention is also paid to the complexity of administrative procedures and the declining social non-demand for refugee status. A special contribution of the author is a comprehensive consideration of the problems of forced migration both through the prism of state and public interests, and in the context of the interests of forced migrants. The novelty of the research lies in the analysis of forced migration processes through the prism of potential partnership relations between the state, society and forced migrants, focusing on the issues of social adaptation and integration of forced migrants as a necessary condition for their social integration and the prevention of crime in their environment.
Initial experience of synchronic description of historical musicology texts
Authors: Bazhanov Nikolai Sergeevich
Published: November 2023

The author discusses a small initial experience of using synchronic description in musicology texts. In the beginning, the origin of the synchrony–diachrony dichotomy introduced into linguistics by Ferdinand de Saussure is revealed. These terms and concepts from linguistics turned out to be so generative in methodological terms that they were adapted into other scientific disciplines. Starting with Saussure, the specificity of the relations of the two approaches is most deeply expressed as the relation of the system of the subject – synchrony and its evolution – diachrony. Next, the article discusses collective intelligence (Lotman) as a result of the activity and cooperation of experts of the same specialty. The productivity and relevance of using a synchronic approach for an adequate comparison of musical works, especially in the history and theory of performing arts, is emphasized. The main objective of the article was to test the use of a synchronic approach for the formation of textual information about the formation of the classical style in musical Europe of the XVIII century. The main pathos and function of the synchronic approach is "comparison". When the beginnings of events are aligned, it becomes possible to compare them (events) with each other, and the results of the comparison are attributed to the synchronization time. The synchronic approach demonstrates the continuity and monomericity of historical time. In synchrony, we see that juxtaposition and comparison overcome the natural separateness of historical events. The conclusions of the article summarize the main properties of the synchronic and diachronic approaches: synchrony reflects the system structure of the object and phenomenon, and diachrony, their evolution. For more productive event matching, synchronization of several parameters and types is necessary. This type of historical research can be described as a multifactorial synchronic analysis of historical events. Further prospects for the development of synchronic and diachronic approaches lie in their synthesis, when multiple slices of synchrony are sorted by chronology, and diachrony consists of synchronic slices of time.
Russian-Belarusian relations of the late 1990s – early 2000s: the view of French researchers
Authors: Trifonova Elizaveta Dmitrievna , Babintseva Ekaterina Alekseevna
Published: November 2023

The article identifies and analyzes the views of modern French researchers on the relations between the Russian Federation and the Republic of Belarus. The study of the works of French scientists makes it possible to analyze Russia's foreign policy not only in relation to its closest neighbor, the Republic of Belarus, but also in relation to the entire post-Soviet space. The subject of the study is the relations between the Russian Federation and the Republic of Belarus in the late 1990s – early 2000s. The article is an attempt to fill the gap in French historiography and analyze the relations between the two former Soviet republics through the prism of French studies. The article also examines the assessments that French authors give to integration associations in the post-Soviet space, as well as to the interaction between the two states in the military and economic spheres. The study is relevant due to the fact that it is the first time the French works devoted to Russian-Belarusian relations in the post-Soviet period have been analysed. Historical, narrative, and comparative-historical methods of historical research were used as the main methods. The author comes to the conclusion that, according to the majority of French researchers, since the collapse of the USSR, relations between the Russian Federation and the Republic of Belarus have been the strongest and most stable compared to other former Soviet republics, despite the obvious great dependence of Belarus on Russia. Moreover, the participation of both countries in the same integration associations and the creation of a common Union State not only speaks about the similar interests of both countries, but it further strengthens the relationship between them.
The function of the teacher in the methodology of fire training
Authors: Vorozhtsov Aleksandr Mikhailovich , Moiseenko Andrei Andreevich
Published: November 2023

The object of the study is such an integral part of the professional service and physical training of employees of internal affairs bodies as fire training. The main purpose of fire training classes is to teach a police officer the skillful use of weapons, the conduct of accurate fire and its lawful use. To do this, it is necessary to "... create an official basic methodology of fire training for law enforcement officers using existing experience in the use of weapons" and highlight the role of the teacher in its implementation. Currently, everyone in various educational organizations uses a methodology based on the professional experience of teachers. The main conclusion can be considered that the educational goals of fire training classes are achieved, including the pedagogical work of teachers in the classroom. These classes should be conducted systematically, consistently and comprehensively. Theoretical classes should be fixed in practical classes. The material part of the weapon should be closely linked to the study of the basics and rules of shooting. The studied topics should be associated with new educational material, work with weapons – with its use, etc. In the classroom, teachers need not only to manage the learning process in the group, but also to implement an individual approach to each listener. Such work of teachers will contribute to the most effective training of employees in the lawful and effective use of weapons.
The principle of clarity in the study of ways to make escapes from custody.
Authors: Chepik Irina Viktorovna
Published: November 2023

The subject of the study is the peculiarity of the use of the principle of visibility in the study of methods of escape from custody by suspects (accused) by employees of the security and convoy units of the police. The author draws attention to the fact that for criminal-legal characteristics at different times, including today, not all methods of escape from custody are important, however, it is necessary to know and recognize them for each police officer, since favorable conditions for escape from custody are more often created by themselves employees of security and convoy units. Using the acquired knowledge, a police officer will be able to reproduce the situation in practice and prevent the escape from custody. The article notes the professional qualities that an employee of the security and convoy service must possess in order to successfully solve the tasks assigned to him and the orientation of training that can contribute to the development of these qualities. The author considers the importance of applying the principle of visibility in teaching, justifies the use of specific means of ensuring visibility that can be illustrated to students, and provides examples. The article examines the violations that contribute to the escape from custody, the methods of its commission, in the study of which examples are used in the form of tables, graphs, photographs, video clips, extracts from court decisions. The position is substantiated that using the principle of visibility improves the perception and memorization of information
Individual training trajectory of future polygraph examiners as an effective pedagogical tool for the formation of professional competencies
Authors: Sadekov Rustem Rafekovich
Published: November 2023

The author in the presented work discusses the topical issues of using the individual trajectory for the students' learning in the educational process of the departmental education system, undergoing professional retraining according to the programs of additional professional education, as an effective pedagogical tool for the formation of the necessary professional competencies. A variable methodology for the formation of individual educational trajectories is proposed, based on the analysis of the needs and capabilities of each student according to vocational training programs in educational institutions of the Ministry of Internal Affairs of the Russian Federation. In the course of applying the possibilities of an individual learning trajectory, it is assumed that this will contribute to a more effective formation of the necessary knowledge. The novelty of the research lies in the fact that the individual learning trajectory, in turn, allows students in a creative format to choose topics that are important in their opinion and scientific and practical directions that most accurately correspond to their needs and interests, and at the same time, in cooperation with teachers, acquire serious practical experience in this field. The pedagogical idea, from the point of view of organizational aspects, is that each educational organization should have a regulatory, legal and pedagogical opportunity to implement individual learning trajectories of students as an effective way to improve the learning process, focused on obtaining fundamental knowledge by students in all areas of science and practice
Silk paintings in the works of modern Chinese artists as a synthesis of traditions and innovations
Authors: An Tianpeng
Published: November 2023

In contemporary Chinese art the national traditions and modern trends of the art world are especially relevant. Since the 1980s, in the works of a number of authors, interest began to manifest itself in the techniques of silk work, which was characteristic of ancient and medieval painting on scrolls, which was later replaced by more accessible drawings on paper. At the present stage, such painting has reached its heyday and is highly appreciated in the art market. The most famous masters engaged in silk painting are Mu Yilin and Dong Wenzheng. The analysis of their creations allows us to see how the artists discovered the expressive possibilities of this material, including its transparency, refraction, color and tone saturation. The object of attention is the Chinese tradition of painting on silk, and the subject is the features of its development at the beginning of the XXI century on the example of the work of famous artists and the options they take into account in the compositions of techniques, figurative structure and expressive means of the old masters. The purpose of the article is to identify the main themes and artistic means that modern artists use in their silk works, as well as the option of integrating an ethno-cultural component into their work.
Auxin Exposure Disrupts Feeding Behavior and Fatty Acid Metabolism in Adult Drosophila
Authors: Fleck Sophie A. , Biswas Puja , DeWitt Emily D. , Knuteson Rebecca L. , Eisman Robert C. , Nemkov Travis , D’Alessandro Angelo , Tennessen Jason M. , Rideout Elizabeth J. , Weaver Lesley N.
Published: November 2023

The ease of genetic manipulation in
Drosophila melanogaster
using the
Gal4/UAS
system has been beneficial in addressing key biological questions. Current modifications of this methodology to temporally induce transgene expression require temperature changes or exposure to exogenous compounds, both of which have been shown to have detrimental effects on physiological processes. The recently described auxin-inducible gene expression system (AGES) utilizes the plant hormone auxin to induce transgene expression and is proposed to be the least toxic compound for genetic manipulation, with no obvious effects on
Drosophila
development and survival in one wild-type strain. Here we show that auxin delays larval development in a widely-used fly strain, and auxin exposure in adult
Drosophila
induces observable changes in physiology and feeding behavior. We found that there is a dosage response to adult survival upon auxin exposure and low auxin concentrations alter feeding activity. Furthermore, auxin fed male and female flies exhibit a significant decrease in triglyceride levels and display altered transcription of fatty acid metabolism genes. Although fatty acid metabolism is disrupted, auxin does not significantly impact adult female fecundity or progeny survival, suggesting AGES may be an ideal methodology for studying limited biological processes. These results emphasize that experiments using temporal binary systems must be carefully designed and controlled for to avoid confounding effects and misinterpretation of results.
PCMT1 knockdown attenuates malignant properties by globally regulating transcriptome profiles in triple-negative breast cancer cells
Authors: Saiding Aili , Maimaitiyiming Dilinuer , Chen Minglan , Yan Futian , Chen Dong , Hu Xinyu , Shi Ping
Published: November 2023

Background

As the most frequently diagnosed cancer in women, Breast cancer has high mortality and metastasis rate, especially triple-negative breast cancer (TNBC). As an oncogene, protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1) is a prognostic biomarker in breast cancer and is highly expressed, while its underlying functions remain unknown.

Methods

In this study, we silenced PCTM1 in TNBC MDA-MB-231 cells by short hairpin RNA (shPCMT1) to investigate its cellular functions using cell proliferation, apoptosis, migration, and invasion experiments. Following this, the transcriptome sequencing (RNA-seq) experiment was conducted to explore the molecular targets of PCMT1, including differentially expressed genes (DEGs) and regulated alternative splicing events (RASEs).

Results

The results showed that shPCMT1 inhibited the proliferation, migration, and invasion of MDA-MB-231 cells. We obtained 1,084 DEGs and 2,287 RASEs between shPCMT1 and negative control (NC) groups through RNA-seq. The DEGs were significantly enriched in immune or inflammation response and cell adhesion-associated pathways, pathways associated with PCMT1 cellular function in cell migration. The RASE genes were enriched in cell cycle-associated pathways and were associated with the altered cell proliferation rate. We finally validated the changed expression and splicing levels of DEGs and RASEs. We found that 34 RNA binding protein (RBP) genes were dysregulated by shPCMT1, including NQO1, S100A4, EEF1A2, and RBMS2. The dysregulated RBP genes could partially explain how PCMT1 regulates the global transcriptome profiles.

Conclusion

In conclusion, our study identified the molecular targets of PCMT1 in the TNBC cell line, expands our understanding of the regulatory mechanisms of PCMT1 in cancer progression, and provides novel insights into the progression of TNBC. The identified molecular targets are potential therapeutic targets for future TNBC treatment.
Análisis del largo de las temporadas de incendios forestales en las regiones de Bío-Bío y la Araucanía en el período 1990-2020
Authors:   , Camus Soruco Francisca Javiera
Published: November 2023

Este estudio examina las tendencias temporales de los incendios forestales en Chile durante las últimas tres décadas. La metodología propuesta presenta una definición probabilística para el inicio y fin de la temporada de incendios, utilizando un modelo aditivo generalizado (GAM) para predecir su probabilidad de ocurrencia. Se ajustaron los GAM utilizando datos de igniciones, variables estacionales y temperaturas diarias de las temporadas comprendidas entre 1990 y 2020 en las regiones de Biobío y Araucanía. Los resultados revelaron una tendencia consistente hacia un inicio de temporada más temprano y un final más tardío de los incendios forestales, independientemente del umbral establecido para la probabilidad diaria de incendio. Esto ha resultado en temporadas de incendios progresivamente más largas durante el período de estudio, aumentando más de un 77% en cantidad de días. Estas tendencias fueron evaluadas utilizando modelos de Regresión Lineal y la prueba de la Pendiente de Sen, se encontraron resultados estadísticamente significativos. Los hallazgos obtenidos son consistentes con investigaciones previas realizadas en Canadá y demuestran de manera estadística y visual que la duración de las temporadas de incendios forestales se está prolongando. Estos resultados son de gran relevancia, ya que proporcionan a las brigadas forestales la información necesaria para mejorar la planificación de las etapas de prevención y combate de incendios en los próximos años.
Perceived Effectiveness of the Mobile Applications in Agriculture in Terms of Availability, Acceptance, Usage and Satisfaction
Authors: Praneeth Machapathri , Arun Kumar S.  , Suresha R. S.
Published: November 2023

The rapid advancement of mobile technology has revolutionized various sectors, including agriculture. Mobile applications have emerged as promising tools to enhance agricultural practices by providing farmers with convenient access to vital information and services. This study aims to investigate the perceived effectiveness of mobile applications in agriculture, focusing on their availability, acceptance, usage, and satisfaction. An Ex-post facto research design was used for the present study. The study was conducted in two districts namely Chikkaballapur and Shivamogga districts of Karnataka state which were purposively selected. Chintamani taluq of Chikkaballapur district and Bhadravathi taluq of Shivamogga district are selected randomly. Two villages (Kaivara and Kurutahalli) from chintamani taluq, Hiriyurua and Nanjapura villages from Bhadravathi taluq were selected based on the simple random sampling method. From each village 30 farmers were selected randomly thus making it a total of 120 farmers from two districts. The four apps Farmrise, AgriApp, Krishi Mithra and Krishi Samyojaka were purposively selected based on its extensive use in the study area. The study showed that 67.50 per cent of the respondents had medium perceived effectiveness about the services of the mobile applications followed by low (19.16%) and high (13.34%) perceived effectiveness. The outcomes of this research contribute to a better understanding of the perceived effectiveness of mobile applications in agriculture and provides valuable insights into the availability, acceptance, usage, and satisfaction levels of these apps among farmers. Farmers are more likely to perceive mobile applications as effective when they are readily available and easily accessible in their daily farming activities. Alignment with specific needs and preferences is crucial for adoption. Promoting usage through training and support improves perceived app effectiveness. Farmer satisfaction, user feedback, and issue resolution enhance this perception. Emphasizing these aspects enables mobile applications to be more finely tuned to meet farmers' specific needs, leading to increased adoption, higher utilization, and ultimately, improved support for agricultural practices.
Prevalence of Dysmenorrhea and its Management among Undergraduate Students of the University of Port Harcourt, Nigeria
Authors: Irozulike Faustina Chiamaka , Asiwe Nicholas , Ekokodje Joy Wilberforce , Wedeh Masterson Sampson , Izibeya James Dibagha , Filima Patrick Leo
Published: November 2023

Background: Dysmenorrhea is a pain felt by women before or during menstruation and is accompanied by some symptoms like headache, dizziness, food cravings, mood swings, and fatigue.  Many ways have been adopted for the management of dysmenorrhea. The study aims to evaluate the prevalence of dysmenorrhea and its management among university students.
Methods: A total of two hundred (200) female university students were involved in this study.  A cross-sectional descriptive study design was used where students were sampled randomly a questionnaire was used to collect data and data obtained were analyzed using IBM SPSS  version 26.
Results: The study found that a majority of the population experiences dysmenorrhea during menstruation (81.5%) and the majority of respondents experienced menstrual flow within 4-5 days with 37% experiencing severe pain. Symptoms include anxiety, mood swings, tender breasts, food cravings, fatigue, irritating mood, depression, dizziness, vomiting, diarrhea, and headache. Management of dysmenorrhea varies, with 23.5% using synthetic drugs and 1.5% using local and herbal practices.
Conclusion: There was a high prevalence of dysmenorrhea among the University students and presenting symptoms like mood swings, fatigue, and diarrhea, with most using local/herbal medication.
Groundwater Quality Assessment in Aba (Abia State) Using WQI and GIS Techniques
Authors: Kanu Ogbonnaya Paul , Ugwoha Ejikeme , Udeh Ngozi U. , Amah Victor
Published: November 2023

Groundwater is considered as the most important source of freshwater for human consumption and activities in the urban environment. The assessment of groundwater quality is critical to avoid the negative effects of polluted groundwater on human health, agriculture, and the economy. In this study, the quality of groundwater in Aba (Abia State), Nigeria was assessed. Thirty-two water samples were taken from sixteen boreholes during the rainy and dry seasons, and analysed for pH, Electrical Conductivity, Total Hardness, Turbidity, Temperature, BOD5, COD, Pb, Cd, Cr, NH3, TDS, SO4, NO3 and PO4. The Weighted Average Water Quality Index (WAWQI) approach was used to compute the Water Quality Index (WQI). Geostatistical analysis methods such as Ordinary Kriging, Empirical Bayesian Kriging (EBK), Inverse Distance Weighting (IDW) and Spline interpolation methods were compared in the spatial evaluation of variable concentrations using ArcGIS. In the dry season, 100% of the borehole locations had Water Quality Index values above 100 which is Unsuitable for drinking purpose. For the rainy season, 87.5% of the borehole locations had WQI values above 100 which is Unsuitable for drinking purpose, 6.25% had WQI which was of very poor quality and 6.25% had WQI values within the range of good water quality between 26 and 50. With a mean error of 0.372483, RMSE of 0.5515, and RMSSE of 1.030492 for the dry season and a mean error of 0.05625, RMSE of 10, and RMSSE of 0.986448 for the rainy season, the EBK interpolation approach was the best fit model for the WQI determination. WQI values for rainy season were generally lower than the WQI values of the dry season, attributable to surface water run-off during the rains.
Preschool Teachers’ Perception on the Development and Promotion of Resilience in Young Children at Kindergarten
Authors: Karela Christina
Published: November 2023

Aims: This paper aimed to examine preschool teachers' perception and understanding on the construct of “resilience” as well as the applied strategies for fostering preschoolers’ resilience at the classroom.

Study Design:  The study was conducted between January 2023 and May 2023 and a qualitative methodological approach was adopted.

Methodology: Data were collected through semi-structured, open questioned interviews with 16 preschool teachers (all women, age range 35- 56 years, with working experience from 5 to 20 years) working in public kindergarten at different regions of Greece territory.

Results: Thematic analysis was applied and the findings indicated that the majority of the participants perceived resilience as the ability to cope with adversity and bounce back, which is cultivated and didn’t constitute a character trait. In relation to the strategies used by preschool teachers to promote resilience they emphasized the significance of the closeness of their relationship with children and family, the enhancement of social- emotional knowledge and skills (self-regulation, maintaining friendly relationships), the development of a positive classroom climate and the adaptation of proactive teaching practices (student-oriented and group-cooperative approach).

Conclusion: Although preschool teachers seemed adequate enough to foster resilience in young children they expressed their desire for more training in this field, as well as the need for support from experts (e.g. school psychologists, educational support structures).
Effect of Risk on Total Debt of Companies Listed on the Nairobi Securities Exchange, Kenya
Authors: Pyoko Oliver Mukweyi , Muchiri Renson
Published: November 2023

Despite the availability issue, debt financing continues to be an essential form of funding for businesses. Risks have been a major source of uneasiness for owners, executives, experts, as well as shareholders globally.  The Kenyan enterprises have a greater susceptible to variations in currency rates in the nation’s economic climate, which is growing to become increasingly open with an increase in global trade. The study objective is to investigate the effect of risk on total debt of companies listed on Nairobi Securities Exchange. The study was underpinned by tradeoff theory and pecking order theory. The study utilized causal research design. Secondary data was used to collect data from yearly accounting statement from 2007-2011. Panel regression was used to analyze the fixed effect model. The result showed that risk negatively and substantially affects total debt. The study recommended that the management of listed firms should understand the tradeoff theory and pecking order theory. The study also recommended that risk should continually be monitored by companies to be in line with the prevailing economic conditions. This can be ensured by studying other factors trend that can affect the risk of companies.
Challenges Facing Women’s Who are Participating in Village Community Bank in Mbarali District
Authors: Gajijime Hansi J.
Published: November 2023

The study aimed at examining challenges facing women's who are participating in VICOBA at Mbarali Disrict. The specific objectives were: to determine social, economic and structural challenges facing women’s who are participating in Village Community Bank, The study used both primary and secondary data. Primary data were collected from 178 respondents using researcher administered questionnaire and 18 key informants by using interview method. The sample size were selected by using purposive and simple random sampling technique. Quantitative data were analysed using Statistical Package of Social Science (SPSS) and qualitative data were analysed by using content analysis technique where data were organized and summarized into different themes and ideas which were expressed by key respondents. The study findings show that 44.9% women faced with a challenge of poor cooperation from VICOBA members, inadequate income 49.4% of women, short loan duration 83.7% revealed by VICOBA women, and structural factors including tough membership conditions by 82.3%. Conclusion, challenge facing women’s participation in VICOBA in Mbarali District were poor education on VICOBA that led them to fail to participate effectively in VICOBA.

Therefore, the study recommends that through proper impletation of policy it can lead to reach the SDGs where encouraging to fight against inequality and the way of ensuring equality is to remove all challenges that facing women’s in their participation in VICOBA.
Assessment of Yield Criteria in Bread Wheat through Correlation and Path Analysis
Authors: Bhardwaj Rashmi , Thakur Sanchit , Mushtaq Muntazir
Published: November 2023

Path coefficient analysis was used by plant breeders to help identify traits that could be useful as a selection criterion for improving crop yield. The path coefficient divides correlation coefficients into direct and indirect effects within the correlation system of traits. When there is a genetic correlation between two traits, the selection for one of them will produce a change in the other trait. In other words, the response of the correlation to the act of selection will take place. The present investigation was conducted during rabi season of 2022-23 at Chamelti Agriculture Farm, MS Swaminathan School of Agriculture, Shoolini University, Solan, Himachal Pradesh. The experiment consisted of 75 genotypes of wheat with three check varieties viz., RAJ 3765, PBW 343 and HP 1633. The experimental field was divided into three blocks of equal size. Twenty-four entries including checks were accommodated in each block. Results indicated that grain yield per plant(g) have a positive and highly significant correlation with biological yield per plant (g), number of productive tillers per plant, harvest index (%), number of grains per spike. Path analysis identified biological yield per plant and number of productive tillers per plant as important direct components for grain yield per plant (g). As per the analysis of variance, variations due to blocks and checks were found to be significant for all the traits. Ten clusters were formed according to Non- hierarchical Euclidean cluster analysis and the maximum inter cluster was recorded between cluster 6 and 8 (86.478), followed by cluster 4 and 8 (83.180). Early maturing genotypes were contained in cluster 1 whereas cluster 4 contained the genotypes which gave the maximus grain yield per plant. High yielding genotypes identified were: DBW- 187, DBW-303, DBW-222, HD-3226 and HS-240. The identified superior can be further utilized in wheat improvement breeding programs.