bluuebunny/crossref_metadata_2025 huggingface dataset:
Normative based beliefs as a basis for perceived changes in personality traits across the lifespan
Authors: Gutral Joanna , Cypryańska Marzena , Nezlek John B.
Published: February 2022

This article presents a new framework for understanding how people think personality changes across the life span. In two studies we examined the correspondence among how people thought their personalities would change, how people in general change, and changes found in a meta-analysis of changes in personality. We conceptualized and measured personality in terms of the Big Five model (FFM). In Study 1 participants rated either how they had changed from the past to the present or how they would change from the present to the future. We found that for openness to experience and social vitality participants thought these traits had increased from the past to the present, whereas participants did not think they would change from the present to the future. In contrast, participants thought that conscientiousness, agreeableness, and emotional stability would increase from the present to the future, although they did not report changes in most of these traits from the past to the present. The changes that occurred in Study 1 correspond to changes of personality found in previous research. In Study 2 participants rated themselves and other people on the FFM traits for each of nine intervals representing the lifespan. We found that people perceived changes in themselves to be similar to the changes found in meta-analyses, and perceptions of change in the self-corresponded to perception of changes for others. We believe these results can be explained by recognizing that people share normative based beliefs about how people change at certain age. Nevertheless, we also found that people perceived themselves as better than others, i.e., relatively greater increases in some positive traits and relatively smaller decreases in some negative traits, being first among equals. We discuss possible explanations for this phenomenon, which according to our knowledge, has not been discussed in this context previously.
A retrospective two centre study of Birt-Hogg-Dubé syndrome reveals a pathogenic founder mutation in FLCN in the Swedish population
Authors: Lagerstedt-Robinson Kristina , Baranowska Körberg Izabella , Tsiaprazis Stefanos , Björck Erik , Tham Emma , Poluha Anna , Hellström Pigg Maritta , Paulsson-Karlsson Ylva , Nordenskjöld Magnus , Johansson-Soller Maria , Aravidis Christos
Published: February 2022

Birt-Hogg-Dube syndrome (BHDS) (MIM: 135150) is a rare autosomal dominant disorder with variable penetrance, caused by pathogenic variants in the FLCN gene. Only a few hundreds of families have so far been described in the literature. Patients with BHDS present with three distinct symptoms: fibrofolliculomas, pneumothorax due to lung cyst formation, and increased lifetime risk of kidney tumours. The aim of the current study was to estimate the incidence of BHDS in the Swedish population and further describe the clinical manifestations and their frequency. Splice variant c.779+1G>T was the most common pathogenic variant, found in 57% of the families, suggesting this may be a founder mutation in the Swedish population. This was further investigated using haplotype analysis in 50 families that shared a common haplotype. Moreover, according to gnomAD the carrier frequency of the c.779+1G>T variant has been estimated to be 1/3265 in the Swedish population, however our data suggest that the carrier frequency in the Swedish population may be significantly higher. These findings should raise awareness among physicians of different specialties to patients presenting with fibrofolliculomas, pneumothorax and/or kidney tumours. We also stress the importance of consensus recommendations regarding diagnosis and clinical management of this, not that uncommon, syndrome.
The behaviour of T2* and T2 relaxation time in extrinsic foot muscles under continuous exercise: A prospective analysis during extended running
Authors: Zaeske Charlotte , Brueggemann Gert-Peter , Willwacher Steffen , Maehlich Daniela , Maintz David , Bratke Grischa
Published: February 2022

Objectives

Previous studies on T2* and T2 relaxation time of the muscles have shown that exercise leads to an initial increase, presumably representing different intramuscular physiological processes such as increase in intracellular volume or blood oxygenation level dependent effects with a subsequent decrease after cessation of exercise. Their behaviour during prolonged exercise is still unknown but could provide important information for example about the pathophysiology of overuse injuries. The aim of this study was to evaluate the temporal course of T2* and T2 relaxation time in extrinsic foot muscles during prolonged exercise and determine the optimal mapping technique.

Methods

Ten participants had to run a total of 75 minutes at their individual highest possible running speed, with interleaved MR scans at baseline and after 2.5, 5, 10, 15, 45 and 75 minutes. The examined extrinsic foot muscles were manually segmented, and relaxation time were analysed regarding its respective time course.

Results

T2* and T2 relaxation time showed an initial increase, followed by a plateau phase between 2.5 and 15 minutes and a subsequent decrease. For the T2* relaxation time, this pattern was also apparent, but less pronounced, with more muscles not reaching significance (p<0.05) when comparing different time points.

Conclusions

T2* and T2 relaxation time showed a similar course with an initial rapid increase, a plateau phase and a subsequent decrease under prolonged exercise. Moderate but long-term muscular activity appears to have a weaker effect on T2* relaxation time than on T2 relaxation time.
Socioeconomic differences in participation and diagnostic yield within the Dutch national colorectal cancer screening programme with faecal immunochemical testing
Authors: van der Meulen Miriam P. , Toes-Zoutendijk Esther , Spaander Manon C. W. , Dekker Evelien , Bonfrer Johannes M. G. , van Vuuren Anneke J. , Kuipers Ernst J. , van Kemenade Folkert J. , van Velthuysen M. F. , Thomeer Maarten G. J. , van Veldhuizen Harriët , de Koning Harry J. , Lansdorp-Vogelaar Iris , van Leerdam Monique E.
Published: February 2022

Background

CRC mortality rates are higher for individuals with a lower socioeconomic status (SES). Screening could influence health inequalities. We therefore aimed to investigate SES differences in participation and diagnostic yield of FIT screening.

Methods

All invitees in 2014 and 2015 in the Dutch national CRC screening programme were included in the analyses. We used area SES as a measure for SES and divided invitees into quintiles, with Quintile 1 being the highest SES. Logistic regression analysis was used to compare the participation rate, positivity rate, colonoscopy uptake, positive predictive value (PPV) and detection rate across the SES groups.

Results

Participation to FIT screening was significantly lower for Quintile 5 (67.0%) compared to the other Quintiles (73.0% to 75.1%; adjusted OR quintile 5 versus quintile 1: 0.73, 95%CI: 0.72–0.74), as well as colonoscopy uptake after a positive FIT (adjusted OR 0.73, 95%CI: 0.69–0.77). The detection rate per FIT participant for advanced neoplasia gradually increased from 3.3% in Quintile 1 to 4.0% in Quintile 5 (adjusted OR 1.20%, 95%CI 1.16–1.24). As a result of lower participation, the yield per invitee was similar for Quintile 5 (2.04%) and Quintile 1 (2.00%), both being lower than Quintiles 2 to 4 (2.20%-2.28%).

Conclusions

Screening has the potential to reduce health inequalities in CRC mortality, because of a higher detection in participants with a lower SES. However, in the Dutch screening programme, this is currently offset by the lower participation in this group.
Risk factors for seizures in the vigorous term neonate: A population-based register study of singleton births in Sweden
Authors: Dickmark Malin , Ågren Johan , Hellström-Westas Lena , Jonsson Maria
Published: February 2022

Background

Neonatal seizures have been associated with increased mortality and impaired neurodevelopment and, knowledge about risk factors may be useful for prevention. Clear associations have been established between labor-related risk factors and seizures in asphyxiated neonates. However, there is limited information about why some vigorous term-born infants experience seizures.

Objectives

Our aim was to assess antepartum and intrapartum risk factors for seizures in vigorous term-born neonates.

Methods

This was a national cohort study of singleton infants born at term in Sweden from 2009–2015. Vigorous was defined as an Apgar score of at least 7 at 5 and 10 minutes. Data on the mothers and infants were obtained from the Swedish Medical Birth Register and the Swedish Neonatal Quality Register. A diagnosis of neonatal seizures was the main outcome measure and the exposures were pregnancy and labor variables. Logistic regression analysis was used and the results are expressed as adjusted odds ratios (aOR) with 95% confidence intervals (CI).

Results

The incidence of neonatal seizures was 0.81/1,000 for 656 088 births. Seizures were strongly associated with obstetric emergencies (aOR 4.0, 95% CI 2.2–7.4), intrapartum fever and/or chorioamnionitis (aOR 3.4, 95% CI 2.1–5.3), and intrapartum fetal distress (aOR 3.0, 95% CI 2.4–3.7). Other associated intrapartum factors were: labor dystocia, occiput posterior position, operative vaginal delivery, and Cesarean delivery. Some maternal factors more than doubled the risk: a body mass of more than 40 (aOR 2.6, 95% CI 1.4–4.8), hypertensive disorders (aOR 2.3, 95% CI 1.7–3.1) and diabetes mellitus (aOR 2.6, 95% CI 1.7–4.1).

Conclusion

A number of intrapartum factors were associated with an increased risk of seizures in vigorous term-born neonates. Obstetric emergencies, intrapartum fever and/or chorioamnionitis and fetal distress were the strongest associated risks. The presence of such factors, despite a reassuring Apgar score could prompt close surveillance.
The association between reactive strength index and reactive strength index modified with approach jump performance
Authors: Pleša Jernej , Kozinc Žiga , Smajla Darjan , Šarabon Nejc
Published: February 2022

Jumping performance is one of the key components of volleyball game, thus evaluating jumping ability through different biomechanical variables offers opportunity for performance optimization. The aim of this study was to assess the associations between reactive strength index (RSI), reactive strength index modified (RSImod) and approach jump performance in male volleyball players. Forty volleyball players performed drop jump (DJ) form 40 cm high box, bilateral and unilateral countermovement jumps (CMJ) and approach jump. RSI in DJ was calculated as the ratio between jump height and ground contact time, while the RSI in CMJ tasks (RSImod) was calculated as ratio between jump height and jump time. Our results indicate that the relationships among different RSI variants and approach jump in volleyball players are moderate to strong (r = 0.42–0.73), with the highest correlations being observed for RSImod from bilateral CMJ (r = 0.676–0.727). Those observations are in line with the principle of movement specificity, which suggests that the best performance indicator should be the task that best resembles the demands of the sport-specific movements. Further research is needed to reveal more about the potential of implementing these findings for training optimization through monitoring RSI and RSImod values.
Identification and assessment of a comprehensive set of structural factors associated with hospital costs in Switzerland
Authors: Havranek Michael M. , Ondrej Josef , Bollmann Stella , Widmer Philippe K. , Spika Simon , Boes Stefan
Published: February 2022

Structural factors can influence hospital costs beyond case-mix differences. However, accepted measures on how to distinguish hospitals with regard to cost-related organizational and regional differences are lacking in Switzerland. Therefore, the objective of this study was to identify and assess a comprehensive set of hospital attributes in relation to average case-mix adjusted costs of hospitals. Using detailed hospital and patient-level data enriched with regional information, we derived a list of 23 cost predictors, examined how they are associated with costs, each other, and with different hospital types, and identified principal components within them. Our results showed that attributes describing size, complexity, and teaching-intensity of hospitals (number of beds, discharges, departments, and rate of residents) were positively related to costs and showed the largest values in university (i.e., academic teaching) and central general hospitals. Attributes related to rarity and financial risk of patient mix (ratio of rare DRGs, ratio of children, and expected loss potential based on DRG mix) were positively associated with costs and showed the largest values in children’s and university hospitals. Attributes characterizing the provision of essential healthcare functions in the service area (ratio of emergency/ ambulance admissions, admissions during weekends/ nights, and admissions from nursing homes) were positively related to costs and showed the largest values in central and regional general hospitals. Regional attributes describing the location of hospitals in large agglomerations (in contrast to smaller agglomerations and rural areas) were positively associated with costs and showed the largest values in university hospitals. Furthermore, the four principal components identified within the hospital attributes fully explained the observed cost variations across different hospital types. These uncovered relationships may serve as a foundation for objectifying discussions about cost-related heterogeneity in Swiss hospitals and support policymakers to include structural characteristics into cost benchmarking and hospital reimbursement.
Helicobacter pylori binds human Annexins via Lipopolysaccharide to interfere with Toll-like Receptor 4 signaling
Authors: Schmidinger Barbara , Petri Kristina , Lettl Clara , Li Hong , Namineni Sukumar , Ishikawa-Ankerhold Hellen , Jiménez-Soto Luisa Fernanda , Haas Rainer
Published: February 2022

Helicobacter pyloricolonizes half of the global population and causes gastritis, peptic ulcer disease or gastric cancer. In this study, we were interested in human annexin (ANX), which comprises a protein family with diverse and partly unknown physiological functions, but with a potential role in microbial infections and possible involvement in gastric cancer. We demonstrate here for the first time thatH.pyloriis able to specifically bind ANXs. Binding studies with purifiedH.pyloriLPS and specificH.pyloriLPS mutant strains indicated binding of ANXA5 to lipid A, which was dependent on the lipid A phosphorylation status. Remarkably, ANXA5 binding almost completely inhibited LPS-mediated Toll-like receptor 4- (TLR4) signaling in a TLR4-specific reporter cell line. Furthermore, the interaction is relevant for gastric colonization, as a mouse-adaptedH.pyloriincreased its ANXA5 binding capacity after gastric passage and its ANXA5 incubationin vitrointerfered with TLR4 signaling. Moreover, both ANXA2 and ANXA5 levels were upregulated inH.pylori-infected human gastric tissue, andH.pylorican be found in close association with ANXs in the human stomach. Furthermore, an inhibitory effect of ANXA5 binding for CagA translocation could be confirmed. Taken together, our results highlight an adaptive ability ofH.pylorito interact with the host cell factor ANX potentially dampening innate immune recognition.
Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung
Authors: Wang Xinxin , Luo Jie , Wen Zhiyuan , Shuai Lei , Wang Chong , Zhong Gongxun , He Xijun , Cao Huizhen , Liu Renqiang , Ge Jinying , Hua Ronghong , Sun Ziruo , Wang Xijun , Wang Jinliang , Bu Zhigao
Published: February 2022

The continuous emergence of severe acute respiratory coronavirus 2 (SARS-CoV-2) variants and the increasing number of breakthrough infection cases among vaccinated people support the urgent need for research and development of antiviral drugs. Viral entry is an intriguing target for antiviral drug development. We found that diltiazem, a blocker of the L-type calcium channel Cav1.2 pore-forming subunit (Cav1.2 α1c) and an FDA-approved drug, inhibits the binding and internalization of SARS-CoV-2, and decreases SARS-CoV-2 infection in cells and mouse lung. Cav1.2 α1c interacts with SARS-CoV-2 spike protein and ACE2, and affects the attachment and internalization of SARS-CoV-2. Our finding suggests that diltiazem has potential as a drug against SARS-CoV-2 infection and that Cav1.2 α1c is a promising target for antiviral drug development for COVID-19.
Cáncer diferenciado de tiroides y gestación
Authors: Delgado-Gómez Manuel , Hoz-Guerra Maria Sonsoles , Alan-Peinado Alexis Rodrigo , Valverde-Márquez Álvaro , Vivas-Vaca Ximena Carolina
Published: February 2022

Introducción y objetivo: el presente trabajo de revisión pretende valorar la influencia mutua que puedan tener la gestación sobre la progresión del carcinoma diferenciado de tiroides, así como la influencia que el carcinoma diferenciado de tiroides pueda tener sobre la gestación. Síntesis: El cáncer de tiroides aparece con frecuencia en mujeres en edad reproductiva y durante el embarazo. Dado que la presentación más común es en forma de nódulo tiroideo, el manejo adecuado de esta patología constituye una prioridad durante la gestación. La ecografía tiroidea y la PAAF guiada por ecografía son herramientas fundamentales tanto para el correcto diagnóstico como para el seguimiento de los nódulos tiroideos. Además, el carcinoma diferenciado de tiroides puede presentarse durante el embarazo en al menos tres escenarios diferentes (recién diagnosticado, microcarcinoma papilar de tiroides bajo vigilancia activa y carcinoma diferenciado de tiroides tratado previamente antes del embarazo) que deben abordarse de distintas maneras. Por lo general, el embarazo no presenta ningún riesgo adicional para el pronóstico de los carcinomas diferenciados de tiroides. Además, el carcinoma diferenciado de tiroides no parece tener una influencia negativa en la progresión del embarazo ni para la madre ni para el feto. El tratamiento de elección de los carcinomas de nueva aparición es la cirugía, que debe posponerse hasta después del parto siempre que sea posible o realizarse en el segundo trimestre en los casos más agresivos. Los microcarcinomas papilares no parecen estar significativamente influenciados por el embarazo y no requieren un seguimiento especial durante la gestación. Para los carcinomas tratados previamente, el embarazo tampoco empeora el pronóstico en la mayoría de los casos. Solo aquellos clasificados como de respuesta estructural incompleta requieren especial atención en su seguimiento. El tratamiento con las dosis correctas de levotiroxina para conseguir los niveles de TSH más adecuados a la situación de riesgo, constituye otro de los pilares fundamentales en el manejo del carcinoma diferenciado de tiroides. Finalmente, el tratamiento con I-131, si fuera necesario, está formalmente contraindicado durante el embarazo y la lactancia.
Microcarcinoma papilar de la glándula tiroides: controversias y manejo actuales
Authors: López Fernando , García-Cabo Patricia , Fernández-Vañes Laura , Coca-Pelaz Andrés , Rodrigo Juan Pablo , Llorente José Luis
Published: February 2022

Introducción y objetivo: El número de pacientes con microcarcinoma papilar de la tiroides (mPTC) cada vez es más elevado. Las guías de práctica clínica han respaldado tanto la vigilancia activa como la cirugía como opciones de tratamiento para el (mCPT). En esta revisión nos planteamos como objetivo describir las opciones actuales de manejo del mCPT. Síntesis: La evidencia acumulada en los estudios realizados ha permitido conocer la historia natural y el comportamiento biológico de estos tumores. Mediante las extensas experiencias, se ha evidenciado que la gran mayoría de estos tumores muchas veces no presentan una variación significativa de su tamaño, o presentan tasas de crecimiento muy lentas, e incluso algunos presentan disminución de éste. La mayoría de mCPT son tumores de bajo riesgo clínico que no generarán morbilidad o mortalidad a pesar de no ser tratados. En los últimos años, la práctica clínica ha evolucionado hacia un tratamiento menos agresivo de estos mCPT para evitar la morbilidad derivada del tratamiento activo mediante cirugía y/o radioyodo y/o supresión hormonal. Los pacientes con tumores de alto riesgo deben ser manejados siguiendo los protocolos de los carcinomas papilares. Sin embargo, la vigilancia activa (VA) de pacientes con tumores de bajo riesgo ha mostrado excelentes resultados oncológicos sin aumentar la morbilidad y la mortalidad. Cuando se indica un tratamiento quirúrgico, la lobectomía es una opción válida para estos tumores. Los criterios de selección inicial para la idoneidad de ser manejados mediante VA deben tener en cuenta muchos aspectos, incluidas las características de los tumores y pacientes. En caso de alto riesgo de progresión deben ser sometidos a una cirugía inmediata en lugar de VA. Conclusiones: La VA ha surgido como una nueva alternativa terapéutica para estos tumores de bajo riesgo, con excelentes resultados oncológicos y menores tasas de complicaciones. No obstante, a pesar de los alentadores resultados de la VA, su implementación en la práctica depende de muchos aspectos entre los cuales se encuentran las características del tumor, las características clínicas del paciente y factores psicosociales.
Impact of polyherbal formulation oral administration on the estrus response, luteal activity, and oxidative stress in postpartum dairy cows with ovarian subfunction
Authors: Amin Yahia A. , Youssef Nasra Ahmed M. , Mahmoud Alaa-Eldin Zain-Elabdeen , Salah Mohammed , Khalil Atef M. H. , Shanab Obeid , Hassaneen Ahmed Saad Ahmed
Published: February 2022

Background and Aim: The reproductive performance of dairy cows is of a high economic value to maintain efficient and sustainable productivity. Postpartum anestrus is one of the major infertility problems that cause limitation of dairy cow reproductive performance and productivity. The previous studies have reported using a polyherbal formulation for different purposes, including reproductive performance. This study was conducted to examine the efficacy of polyherbal formulation administration on the reproductive performance of cows and to establish the oral administration of polyherbal formulations as a safe, effective, and economic treatment for dairy cows with postpartum anestrus due to nutritional disorders, negative energy balance, high milk production, and/or heat stress. Materials and Methods: A total of 14 dairy cows with postpartum anestrus were randomly divided into two groups, which were subjected to oral administration of distilled water that served as the control (Ctrl; n=5) or polyherbal treatment (polyherbal treated; n=9) for two shots of treatment (each for 3 successive days) with a 10-day interval. Blood sampling and ultrasonography were performed before treatment and after the first and second shots of treatment. Progesterone (P4) assay was also performed. Results: The estrus induction rate was 66.7% after the first shot of treatment in the polyherbal-treated group, which increased significantly to 88.9% after the second shot of treatment, compared with the Ctrl group (20%). The estrus response was confirmed by ultrasonography and P4 hormone assay, wherein the polyherbal treatment significantly increased the P4 concentration in the polyherbal-treated group after the second shot of treatment compared to that before treatment and in the Ctrl group at all time points. On pregnancy diagnosis, the treated dairy cows showed conception rates of 66.7% and 20.0% in the polyherbal-treated and Ctrl groups, respectively. In contrast, the concentration of malondialdehyde, an oxidative stress marker, and the total antioxidant capacity remained unchanged between both groups before and after treatment. Conclusion: The polyherbal formulation containing tubers of C. rotundus, M. pterygosperma, rhizome of Z. officinale, and A. cepa has the potential to induce estrus response and luteal activity in dairy cows and is a possible treatment for ovarian inactivity in dairy farms.
A Retrospective Study on Clinical and Biochemical Profile of Neuroleptospirosis
Authors: Chellappan Ajitha Kesi , Pillai Padmakumar Rajashekharan , Sam Regi David , Narayanan Ajith Syamala
Published: February 2022

BACKGROUND Leptospirosis is a zoonotic disease usually reported from South India. The clinical spectrum may range from asymptomatic infection, subclinical to a fatal hepatorenal syndrome. Most physicians are sensitized to diagnose leptospirosis, sometimes the diagnosis is missed, especially when associated with neurological manifestations. About 10-15 percent of cases can have neurological manifestations. These patients are referred to a tertiary care hospital due to poor therapeutic response. Since early management can be lifesaving, this study was carried out to evaluate the laboratory profile and clinical features in patients with neuroleptospirosis in a tertiary care centre in South India. METHODS This retrospective single centre study was conducted at Government Medical College, Thiruvananthapuram, Kerala. Neuroleptospirosis was diagnosed by clinical and laboratory findings of hepatorenal syndrome, and anti leptospira antibody detection by ELISA. RESULTS Total of 160 patients with leptospirosis were admitted during the period of study. 31 patients were diagnosed clinically as neuroleptospirosis. Out of 31 patients 21 (67.7 %) were males and 10(32.3 %) were females. The mean age was 56.9  14.61 years. (M: F 2:1, range 18-68 years,). The chief manifestations were fever in 29 (93.5 %), myalgia in 23(74.2 %), headache in 17 (54 %), jaundice in 14 (45 %), and conjunctival suffusion in 9 patients (29 %). Two patients (6.4 %) had altered sensorium and neck stiffness in 23 patients (74.19 %). Most common neurological manifestation was aseptic meningitis (87) followed by encephalitis (19.4 %), seizures in 9.7 %, mean WBC count was 17297.10  8948.413 cells/microliter. Mean platelet count at admission was 88258.06  108727.478 cell/microliter. Mean serum creatinine was 3.9  2.3 mg/dl. Seven  patients (22.58 %) succumbed to death. Mean age of patients who died were 50.63  11.94 years (p < 0.084), mortality was more common in females (50 %) (p < 0.074). Irrespective of age and sex, WBC count at admission > 18,800 cell/ μL is associated with increased mortality (p+0.032). CONCLUSIONS Early recognition of neuroleptospirosis in patients with hepatorenal dysfunction and altered sensorium is critical in the treatment of patients. Female gender and elevated WBC count at admission indicates poor prognosis. KEY WORDS Neuroleptospirosis, Prognosis, Aseptic Meningitis.
Patterns of HRCT Findings and Its Clinical Correlation in Covid-19 Patients of a Tertiary Care Hospital in Assam
Authors: Sarma Nayan Mani , Roy Deep Kumar , Bhuyan Rupak , Bora Mohsina Islam
Published: February 2022

BACKGROUND Covid-19, which is usually transmitted from droplet exposure, proved out to be a novel disease of human race. It is still unclear whether the new coronavirus can transmit in any other ways, but it can be detected in nasal swabs, sputum, respiratory secretions, blood, stool, and other samples. Early detection and prompt intervention play a vital role in reducing the number and severity of cases. METHODS Our study sample consisted of 100 patients from the Department of Radiodiagnosis, Jorhat Medical College & Hospital (JMCH) diagnosed as Covid-19 from April 2020 to March 2021. Reviewing of chest CT images with clinical data was done and analysis of its relationship was reviewed. All the cases underwent thin-slice HRCT for at least a single time. RESULTS The most common CT findings observed were ground glass opacity (91%), consolidation (63%), and inter & intra lobular septal thickening (59%). We encountered multiple lesions, with an average of 13 ± 5 pulmonary segments infected. CONCLUSIONS Computed tomography thus, has a pivotal role in the prognostication of Covid-19 pneumonia which is an emergency global health epidemic. It helps us to detect and analyse the common chest manifestation of Covid-19 vis; consolidation, ground glassing, septalthickening, subpleural bands and occasional pleural effusions. KEY WORDS Covid-19, Pneumonia, Chest CT Scan, Ground Glassing, Interlobular Septal Thickening
A Multivariate Fuzzy Clustering-Based Data Imputation for Adaptive Misbehavior Detection in Cooperative Intelligent Transportation Systems
Authors: Almalki Sultan , Sheldon Frederick
Published: February 2022

This work proposes a local-global fuzzy-clustering feature extraction scheme for detecting False Data Injection Attacks (FDIA). In this scheme, the data undergo several pre-processing steps including missing values imputation based on the local and global fuzzy-clustering correlation approach. There are four main components of the proposed method: i) data acquisition, ii) standardization, iii) normalization, and iv) imputation. To evaluate the performance of this scheme, the NGSIM dataset (described below) was used. This dataset contains data acquired from the environment using a set of sensors that collect data from the neighboring vehicles. The results show that the accuracy of models trained using said features extracted by the proposed scheme was higher than those proposed by the related studies. This indicates that the local-global fuzzy clustering data imputation approach proposed by this study can estimate the missing values better than existing techniques based on an exhaustive literature review.
Riesgos del personal que labora en atención prehospitalaria: Reto para los servicios de emergencia
Authors: Díaz-Tamayo Alejandra María
Published: February 2022

La atención prehospitalaria o la respuesta a una emergencia en el escenario prehospitalario, definido en un contexto internacional, comprende todas las intervenciones médicas y de transporte realizadas a pacientes que presentan eventos médicos o traumáticos en diferentes escenarios fuera del ámbito hospitalario. Quienes realizan la labor prehospitalaria deben enfrentarse a situaciones y escenarios variados, complejos y no controlados; todas estas situaciones implican estar expuestos a una variabilidad de riesgos que pueden ser prevenibles si se toman las medidas necesarias para mitigarlos. Los riesgos biológicos, biomecánicos, psicosociales, físicos, asociados a la violencia física y verbal, entre otros, exponen a este personal al desarrollo de accidentes de trabajo y enfermedades laborales en muchas ocasiones de magnitudes severas y con graves consecuencias. Caracterizar la labor prehospitalaria plantea muchos desafíos, la atención del paciente varía con cada llamada, y esta, a su vez, presenta retos únicos dependiendo del estado clínico, la necesidad de cada paciente y el escenario donde se está presentando el evento. Conocer con más detalle los riesgos laborales de esta profesión que diariamente se expone a situaciones diversas y diseñar estrategias para mejorar la salud y el bienestar de los trabajadores de esta área, se traduce en una atención médica de emergencia más efectiva y eficiente, contribuyendo a mejorar la calidad y a fortalecer los sistemas de salud en el ámbito prehospitalario.
Prevalencia de los signos de Finkelstein y Eichhoff en una población sana
Authors: Vergara - Amador Enrique , Camacho Castro Felipe
Published: February 2022

Introducción: La enfermedad de De Quervain es frecuente en población laboralmente activa y su diagnóstico puede ser un reto. Las maniobras de Finkelstein y Eichhoff son pruebas semiológicas utilizadas para el diagnóstico de esta patología, cuyo rendimiento diagnóstico real no es claro. El objetivo de este trabajo es determinar la prevalencia de los signos de Finkelstein y Eichhoff en una población de individuos sanos en edad laboral, buscando determinar el valor real de un hallazgo positivo. Materiales y métodos Es un estudio de corte transversal, descriptivo. La muestra está conformada por individuos sanos entre los 18 y 45 años, de sexo masculino y femenino, que participan de forma voluntaria. A todos los participantes se les realizaron ambas maniobras, se llevó registro de las pruebas que resultaron positivas y de los pacientes que refirieron dolor o incomodidad. Resultados Participaron 65 pacientes y se registraron datos de 129 extremidades. La edad promedio fue 26 años, El número promedio de horas laborales diarias fue 9,3. El signo de Finkelstein tuvo una prevalencia de 33,3%; el signo de Eichhoff de 75,2%. La única variable que aumenta el riesgo de presentar una prueba positiva (Eichhoff) de forma estadísticamente significativa es el sexo masculino (OR 2,4, IC 95% 1,05-5,73). Conclusiones El signo de Finkelstein es más específico que el de Eichhoff, sin embargo, no es patognomónico de tenosinovitis de DeQuervain. La maniobra de Eichhoff no es recomendable para la exploración física de los pacientes, puede ser incómoda y generar confusión.
Deficiencia de butirilcolinesterasa:Una revisión narrativa de la literatura
Authors: Vega Useche Leonel Santiago , Gualdrón Frías Carlos Andrés , Calderón Nossa Laura Tatiana , Larrotta Salamanca Lady Ximena , Rueda Marín Elkin Duván
Published: February 2022

La butirilcolinesterasa es una enzima que metaboliza relajantes neuromusculares despolarizantes como la succinilcolina, fármaco de elección para procedimientos que requieran parálisis muscular a corto plazo como facilitar la intubación endotraqueal en pacientes sometidos a procedimientos de emergencia. La deficiencia de butirilcolinesterasa puede definirse como una reducción cuantitativa o cualitativa de la enzima y su actividad para hidrolizar moléculas, constituyéndose como la principal causa de bloqueo neuromuscular prolongado tras la administración de relajantes neuromusculares como la succinilcolina. Es una condición de origen hereditario o adquirido, siendo más común la deficiencia enzimática de origen genético y de carácter autosómico recesivo presentándose aproximadamente en una de cada 3200 a 5000 personas en todo el mundo. Su manifestación clínica se caracteriza por relajación muscular persistente la cual puede producir una insuficiencia respiratoria aguda. El diagnóstico debe ir orientado a la identificación de sus características clínicas, la cuantificación serológica y el monitoreo neuromuscular. Debido a que no existe una cura de esta deficiencia, el manejo debe ir orientado a realizar ventilación mecánica del paciente hasta que el medicamento empleado se metabolice por completo. Este artículo tiene como objetivo realizar una revisión del estado del arte, describiendo su epidemiología, etiología, fisiopatología, manifestaciones clínicas y actualidades en su diagnóstico y tratamiento.
Mental Health of Immigrants in a Shelter in Tabasco, Mexico During the COVID-19Epidemic
Authors: Cano Collado Luz Alejandra , Hernández Marta , Priego Álvarez Heberto Romeo
Published: February 2022

Migration is a global phenomenon that must be recognized as a social de-terminant of health. In 2020, there were 280 million international migrants in the world. Undoubtedly, Mexico plays a fundamental role in transnational migration due to the large flow of migrants who transit through its borders. Research on mental health and migra-tion suggests a high prevalence of mental disorders due to the conditions of the migration process; this scenario may be aggravated as result of the health contingency caused by CO-VID-19. Methodology: This research is intended to identify the relationship between the mental health of migrants, the migratory process, and the COVID-19 epidemic. Therefore, it is a qualitative study with a deductive approach. A sample evaluation of Central Ameri-can migrants living in a shelter in Tabasco, Mexico in December 2020 was used. Results: Some factors impact the mental health of migrants in the place of origin and during transit (forced migration, persecution, and the lack of possibilities to achieve a decent standard of living...). Moreover, positive, and negative manifestations were reported in the dimensions of mental health, because of the migratory process and COVID-19. Conclusions: Migration has become an option for survival and well-being given the limited opportunities that exist in the regions of origin. Efforts must be made to develop migration and health policies that benefit this group. Unfortunately, some limitations of data collection emerged due to Covid 19. Finally, it is suggested to replicate the study among other areas of the southern border of Mexico with a high flow of migrants.
Protocolo para la Atención Odontológica Durante la Pandemia por SARS-CoV-2
Authors: Corrales Castañeda Alexandra , Palacio Blanco Hugo , Rebolledo Cobos Martha , Carmona Lorduy Martha
Published: February 2022

En diciembre de 2019 se identificó por primera vez en Wuhan China el SARS-CoV-2, un nuevo tipo de coronavirus de la familia Coronaviridae del género ?-CoV. El 11 de marzo del 2020 la OMS lo declara pandemia y hasta el 19 de diciembre de 2021 han sido afectados 192 países con 235 547 850 casos confirmados y 4 811 951 personas fallecidas. El SARS-CoV-2 afecta a los humanos, sin distinción de género, raza o edad, pero las personas con comorbilidades como hipertensión arterial, enfermedades cardiovasculares o diabetes Mellitus tienen peor pronóstico. Entre las rutas de transmisión de persona a persona se describen el contacto directo con mucosas y por inhalación de aerosoles o saliva. Por lo cual solo con guantes, mascarilla quirúrgica y visor como protección, los profesionales con más alto riesgo de contagio son los odontólogos, al estar en contacto directo con el paciente, con instrumental, materiales contaminados de fluidos del paciente y con los aerosoles que se generanen algunos de los procedimientos que realizan.Se realizó una búsqueda bibliográfica en PubMed, JOMOS, NIH y CDC, analizando los datosencontrados para proponer los cambios más adaptables a nuestro entorno.El objetivo de este trabajo de revisión de información reciente y relevante acerca de la atenciónodontológica en tiempos de SARS-CoV-2, es proponer cambios estructurales en la atención, para garantizar la bioseguridad de pacientes, personal odontológico y talento humano presente en la consulta odontológica.
Job insecurity, subjective well-being and job performance: the moderating role of growth mindset
Authors: Setjo Epic Anung Anindita , Franksiska Rosaly
Published: February 2022

This study aims to analyze the impact of job insecurity on subjective well-being and the impact on job performance, with a growth mindset as the moderating variable.  The COVID-19 pandemic has been running for more than 1 year and this research was conducted during the pandemic period. Due to the COVID-19 pandemic, many companies and other units were adversely affected so that the companies’ performance declined, PT Armada Finance is one of those. Therefore, this study expected that job insecurity influences subjective well-being, and subjective well-being influences job performance. Furthermore, a growth mindset is also expected to have a moderating influence on the subjective well-being of the employees to increase job performance. The results of regression and moderated regression analysis (MRA) on 75 samples collected from employees of PT Armada Finance company in Magelang, Central Java, Indonesia, show that job insecurity does not influence subjective well-being. The result also shows that subjective well-being has a positive influence on job performance. In addition, this study also suggests that having a growth mindset could be moderating subjective well-being to increase job performance.
The effect of perceived organizational support and psychological capital on OCB: mediating role of engagement
Authors: Ansori Muhammad Ali , Wulansari Nury Ariani
Published: February 2022

This paper aims to investigate the effect of psychological capital (PsyCap) as an intrinsic factor and perceived organizational support (POS) as an extrinsic factor on OCB and to verify the mediating role of work engagement (WE) in the relationship of PsyCap, POS and OCB. The population in this study are state university lecturers especially at Universitas Negeri Semarang. Using proportionate random sampling technique, the data was collected from 145 lecturers. The structural equation model-partial least square (SEM-PLS) was used to test the hypotheses with analysis tools in the form of SmartPLS 3.0. The result showed that PsyCap had a positive and significant effect on work engagement and OCB, then POS had an insignificant effect on OCB and work engagement. The result found that work engagement has a mediation effect in the relationship between PsyCap and OCB. This study also showed that PsyCap as an intrinsic factor is considered more capable than POS as an extrinsic factor to improve lecturer’s OCB. It is highly recommended for the organization to focus on lecturer’s psychological capital investment, because lecturer’s PsyCap will be directly affect to lecturer’s positive behaviour such as work engagement and OCB.
Determinants of firm value: evidence from listed insurance companies in Indonesia
Authors: Ismiyatun I , Aryani Nafiah , Ispriyahadi Heri
Published: February 2022

This study was conducted to determine the effect of Return on Asset (ROA), Debt to Equity Ratio (DER), and Current Ratio (CR) on firm value in insurance companies listed in Indonesia Stock Exchange from 2015 to 2019. The population in this research was 12 companies in various Insurance listed in the Indonesian Stock Exchange. The analytical method used three regression estimations (pooled OLS, fixed effects model (FEM), and random effects model (REM)). The results indicated that the Return on Asset, Debt to Equity Ratio, and Current Ratio had a significant negative effect on firm value. Our key finding from this research showed that when the profit was higher, the companies prefer to hold their earnings and use for an investment to generate growth opportunities. This phenomenon had explained when companies had higher yields, the firm's value went down. Therefore, this research is following the Pecking Order Theory. Further interaction analysis between DER and CR on firm value uncovers that both DER and CR also negatively affect firm value.
The Bastille Effect: Transforming Sites of Political Imprisonment
Authors: Welch Michael
Published: February 2022

The “Bastille Effect” refers to the unique ways that former sites of political imprisonment are transformed, physically and culturally. In their afterlives, these sites represent sustained efforts to hold perpetrators accountable for state violence. For that narrative to surface, the sites must be cleansed of their profane past. In some cases, clergy are even enlisted to perform purifying rituals that grant the sites a new identity as memorials. Around the globe, carceral sites have been dramatically repurposed into places of enlightenment that offer inspiring allegories of human rights. Interpreting the complexities of those common threads, this book weaves together a broad range of cultural, interdisciplinary, and critical thought to offer new insights into the study of political imprisonment, collective memory, and post-conflict societies.
Trauma w procesie – o podlaskiej recepcji bieżeństwa
Authors:   Wydział Filologiczny, Uniwersytet w Białymstoku, Sawicka-Mierzyńska Katarzyna
Published: February 2022

The article discusses the reception of bieżeństwo – the exodus of about three million inhabitants of the western borderlands of the Russian empire deep into Russia in 1915. It was part of the “scorched earth” tactics conducted by the tsarist authorities, which were supposed to hinder the German army’s march eastward. Using the category of “cultural trauma” formulated by J.C. Alexander, the author seeks to dicover why biezenstwo did not become a part of the collective memory of Poles and how it now functions in the collective memory of Podlasie residents. The research was based primarily on Aneta Prymaka-Oniszk’s reportage Bieżeństwo 1915. Zapomniani uchodźcy [Biezhenstvo 1915. Forgotten refugees] and the anthology Jestem, bo wrócili [I am because they came back].
W awangardzie humanistyki materialistycznej. Spory teoretyczno-ideologiczne Stefana Żółkiewskiego w „Kuźnicy”
Authors:   Wydział Polonistyki, Uniwersytet Warszawski, Sidorowicz Piotr
Published: February 2022

The paper discusses the development of Stefan Żółkiewski’s theoretical and ideological position in the second half of the 1940s, analyzing his most important publications in “Kuźnica”. The author attempts to define the components of Żółkiewski’s theoretical habitus in relation to specific trends in contemporary humanities, such as phenomenology, formalism, neo-positivism, idealism or neotomism. In this way, the paper identifies the basic components of Żółkiewski’s scientific worldview (or, to use Henryk Markiewicz’s term “ideogems”), which in the Polish humanities of that time correspond to Marxism.
Wspólnota rozszerzona
Authors:   Wydział Filologiczny, Uniwersytet w Białymstoku, Głowacka Ewelina
Published: February 2022

This article is a discussion of Anita Jarzyna’s book Post-koine. Studia o nieantropocentrycznych językach (poetyckich) [Post-koine. Studies of non-anthropocentric (poetic) languages] (2019), which analyses non-anthropocentric narratives in contemporary Polish poetry. The reviewer introduces the problematics of the monograph and notices the non-obvious choice of works interpreted by Jarzyna, who is primarily interested in glimpses of the non-anthropocentric perspective in authors not associated with the ecocritical writing. Taking into account various interpretative contexts, the author presents a wide spectrum of issues from the field of animal studies, and she also argues that poetry is both a reflection and a harbinger of changes that are taking place in the collective imagination.
Zadowolenie z małżeństwa. Pedagogiczne implikacje dotyczące osobistego rozwoju małżonków, relacji małżeńskich i rodzicielskich
Authors:   Wydział Nauk o Edukacji, Uniwersytet w Białymstoku, Dakowicz Andrzej
Published: February 2022

Working under the assumption that the marital relationship has the greatest influence on the atmosphere of family life, 75 married couples performing parental tasks were examined and divided, using M. Braun-Gałkowska’s Marriage Success Scale, into two groups: married couples with a higher and lower level of satisfaction with their relationships. Next, the personality characteristics of the surveyed spouses were determined and compared using the following research tools: H.G. Gough’s and A.B. Heilbrun’s Adjective Check List, Z. Uchnast’s Sense of Security Questionnaire, the Emotional Intelligence Questionnaire developed by A. Ciechanowicz, A. Jaworowicz, A. Matczak, the Social Competence Questionnaire developed by A. Matczak, M. Kaźmierczak’s and M. Plopa’s Questionnaire of Marriage Communication, M. Braun-Gałkowska’s Family Attitudes Scale. Spouses with a higher level of satisfaction with their relationship, when compared to spouses with a lower level of satisfaction, are characterized by greater socialization, selfcontrol, and kindness; they obtained higher results determining their level of emotional intelligence and the effectiveness of their behaviours in intimate situations. The presented characteristics of spouses with a higher level of satisfaction with their relationship can be achieved as a result of personal development and, above all, of ongoing dialogue in the ever-changing reality of marital life. Taking advantage of the expanding offer of various forms of individual and group support can be useful in this respect. Workshops based on the participants’ involvement and referring to their own experiences are particularly helpful in working on personal development and deepening the marital relationship.