bluuebunny/crossref_metadata_2025 huggingface dataset:
PCSK9 inhibitors attenuates arterial stiffness in patients with acute coronary syndrome
Authors: Wang Liang , Wang Ruijie , Jiao Tiantian , Xu Linghao , Ji Endong , Jiang Yuanzhen , Wang Yuanqi , Liu Yehong , Li Jiming
Published: December 2023

BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors has been demonstrated to exert a great protection in acute coronary syndrome (ACS) with atherosclerosis. However, the effect of these drugs on vascular function, such as arterial stiffness (AS), has not been extensively described yet.
OBJECTIVE: This study focuses on uncovering the actions of PCSK9 inhibitors on attenuates AS.
METHODS: The experiment was randomly divided into 2 groups, one treated with statin and PCSK9 inhibitors (Evolocumab or Alirocumab) and the other with statin alone. Detected the indicators of lipid metabolism and AS were at the beginning of treatment, 1 month and 6 months after treatment.
RESULTS: With 1 month treatment of statin and PCSK9 inhibitors, the levels of LVEF, NTP, TC, TG, LDL, Lp(a) in the patients had reduced already more apparently than only with statins. Until 6 months follow-up, pulse wave velocity had improved notably (p-value＜0.05), and ankle brachial index had also decreased significantly undergoing treatment with statins and PCSK9 inhibitors (p-value＜0.05), no differ significantly by Evolocumab or Alirocumab (p-value＞0.05).
CONCLUSIONS: In summary, this research suggested that PCSK9 inhibitors can not only improve lipid metabolism, but also attenuate AS, which give a further rationale for using PCSK9 inhibitors for its effect in vascular disorders.
Deep learning pose detection model for sow locomotion
Authors: Paula Tauana Maria Carlos Guimarães , Sousa Rafael Vieira , Sarmiento Marisol Parada , Kramer Ton , Sardinha Edson José Souza , Sabei Leandro , Machado Júlia Silvestrini , Vilioti Mirela , Zanella Adroaldo
Published: December 2023

Lameness affects animal mobility, causing pain and discomfort. Lameness in early stages often goes undetected due to a lack of observation, precision, and reliability. Automated and non-invasive systems offer precision and detection ease and may improve animal welfare. This study was conducted to create a repository of images and videos of sows with different locomotion scores and develop a computer vision model for automatically identifying and tracking specific points on the sow's body to facilitate lameness detection using deep learning. The video database was collected on a pig farm with a scenario built to allow filming of sows in locomotion with different lameness scores. Two stereo cameras were used to record 2D video images. Thirteen locomotion experts assessed the videos using the Locomotion Score System developed by Zinpro Corporation. From this annotated repository, computational models were trained and tested using the open-source deep learning-based animal pose tracking framework SLEAP (Social LEAP Estimates Animal Poses). The top-performing models were constructed using the LEAP architecture to accurately track 6 (lateral view) and 10 (dorsal view) skeleton keypoints. The architecture achieved average precisions values of 0.90 and 0.72, average distances of 6.83 and 11.37, and similarities of 0.94 and 0.86 for the lateral and dorsal views, respectively. These computational models are proposed as a Precision Livestock Farming tool and method for identifying and estimating postures in pigs automatically and objectively. The 2D image repository with different pig locomotion scores can be used as a tool for teaching and research. Based on our skeleton keypoint classification results, an automatic system could be developed. This could contribute to the objective assessment of locomotion scores in sows, improving their welfare.
Suture fixation of the levonorgestrel-releasing intrauterine device with hysteroscope for the treatment of adenomyosis in patients at high risk of device expulsion
Authors: Mao Min , Gou Yuan-Qin , Xu Ning , Li Min , Li Meng-Xi , Luo Zhi-Gui , Li Yuan-Hong , Tong Yu
Published: December 2023

Objective: This study aimed to investigate the safety and efficacy of suture fixation of the levonorgestrel-releasing intrauterine device (LNG-IUD) through hysteroscope fortreatment of adenomyosis in patients at high risk of device expulsion.
Methods: 21 patients with adenomyosis were fixed with the LNG-IUD on the uterine wall close to the base of the uterus by hysteroscopy.
Subjects: with adenomyosis who are at high risk of device expulsion.
Results: All 21 patients were successfully fixed with the LNG-IUD on the uterine wall close to the base of the uterus by hysteroscopy. Pictorial Blood Loss Assessment Chart (PBAC) and visual analogue scale (VAS) scores showed a significant decrease after 1 and 3 months after surgery compared with the baseline value. Serious IUD complications including expulsion and perforation were not observed.
Conclusion:Suture fixation of the LNG-IUD through hysteroscope is a safe, effective, and minimally invasive surgical procedure to prevent IUD expulsion for the treatment of adenomyosis in patients who are at high risk of device expulsion.
Cost-effectivenees Analysis of the Use of Power Circular Versus Manual Circular Staplers for Left-side Colorectal Anastomosis
Authors: Pla-Martí Vicente , Martín-Arévalo José , Moro-Valdezate David , García-Botello Stephanie , Perez-santiago Leticia , Barrachina-Martínez Isabel , González-de-Julian Silvia , Vivas-Consuelo David , Espí-Macías Alejandro
Published: December 2023

BACKGROUND
Colorectal anastomotic leakage causes severe consequences for patients and health care system as it will lead to an increased consumption of hospital resources and costs. Technological improvements in anastomotic devices could reduce the incidence of leakage and its economic impact. The aim of the present study was to asses if the use of the new powered circular stapler is cost-effective.
METHOD
Observational study including patients undergoing left-sided circular stapled colorectal anastomosis between January 2018 and December 2021. Propensity score matching was carried out to create two comparable groups depending on whether the anastomosis was performed using a manual or powered circular device. The rate of anastomotic leakage, its severity and the consumption of hospital resources and its cost were the main outcome measures. A cost-effectiveness analysis comparing the powered circular stapler versus manual circular staplers was realized.
RESULTS
Anastomotic leakage rates were significant different (p=0.012); 22 patients (13.3%) in the manual group (9.1% treated surgically and 4.2% managed conservatively) and 8 patients (4.8%) in the powered group (3.6% treated surgically and 1.8% managed conservatively).
The effectiveness for powered stapler was 98.27%, while the effectiveness of manual stapler was 93.69 %. The average cost per patient in the powered group was €6,238.38, compared with €9,700.12 in the manual group. The incremental cost-effectiveness ratio was -€74,915.28€ per patient without anastomotic complications.
CONCLUSION
The incremental cost of powered circular staple compared with manual devices was offset by the savings from lowered incidence and cost of management of anastomotic leaks.
Applying taper function models for black locust plantations in Greek post-mining areas
Authors: Wilms Florian , Berendt Ferréol , Bronisz Karol , Bashutska Ulyana , Fotelli Mariangela , Radoglou Kalliopi , Spyroglou Gavriil
Published: December 2023

A key process in forest management planning is the estimation of tree volume and, more specifically, merchantable volume. The ability to predict cumulative stem volume to any upper stem diameter on standing trees or stands is essential for forest inventories and management of forest resources. In the 1980s, the Hellenic Public Power Corporation (HPPC) started the rehabilitation of lignite post-mining areas in Greece by planting mainly black locust (Robinia pseudoacacia, L.). Today, these plantations occupy an area of about 2570 ha, but the stem volume has not yet been estimated. Therefore, we aimed at estimating the over- and under-bark stem volume using taper function models for 30 destructively sampled trees. Of the nineteen calibrated fixed-effects models, Kozak’s (2004) performed best for both the over-bark and under-bark datasets, followed by Lee’s (2003) and Muhairwe’s (1999) equations. The addition of random effects on a single-stem basis for two coefficients of Kozak’s (2004) equation improved the model fit significantly. Two locally calibrated models were cross validated with calibration coefficients from Poland and the United States. Integrated taper functions were found to slightly outperform three tested volume equations for volume predictions of single stems over and under bark. A validation data set for the taper model verified that those models can be used to predict diameter at a specific point along the stem, merchantable volume, and total stem volume of black locust plantations. Finally, it can be said that taper models permit flexible volume estimation for the population average as well for specific trees.
Mendelian Randomization Identifies Two Immune Cell Traits Associated with Lung Cancer
Authors: Xie Lin , Li Juan , Chen Xushan , Xu Mingzhi , Lei Yahan , Xie Jiajia , Tang Xiaona
Published: December 2023

Background
Experimental evidence has linked immune cells to lung cancer. It is unclear whether associations for immune cell traits are causal or due to bias. To explore the causal impact of immune cells on lung cancer risk, we conducted a two-sample Mendelian randomization (MR) analysis.
Materials and Methods
We analyzed the relationship between immune cell traits and lung cancer using a two-sample MR approach. Genome-wide association study (GWAS) summary statistics for 731 immune cell traits and lung cancer risk were assessed. The immune cell characteristics included four types: absolute cell (AC) counts, median fluorescence intensities (MFIs) of surface antigens, morphological parameters (MP) and relative cell (RC) counts. GWAS associated with lung cancer was extracted from a large-scale association analysis that included 29,266 cases and 56,450 controls. Inverse Variance Weighted (IVW) was performed as the primary MR analysis method. Multiple sensitivity analyses are used to evaluate the robustness of the results. Finally, a reverse MR analysis was conducted to assess the possibility of reverse causation.
Results
MR analysis showed that CD14- CD16 + monocyte %monocyte(OR = 0.924; 95%CI,0.889–0.960) and CD4 on naive CD4+(0.922, 0.889–0.956) was associated with overall lung cancer after accounting for multiple testing. There was no statistically significant effect of immunophenotypes for lung cancer subtypes.
Conclusions
Our findings suggest that CD14- CD16 + monocyte %monocyte and CD4 on naive CD4 + might protect against lung cancer, and larger-scale genetic data are expected to further validate our findings.
Risk Assessment and Source Analysis of Heavy Metals in Soil around an Asbestos Mine in an Arid Plateau Region, China
Authors: Li Xuwei , Ding Da , Xie Wenyi , Zhang Ya , Kong Lingya , Li Ming , Li Mei , Deng Shaopo
Published: December 2023

Asbestos is widely used in construction, manufacturing, and other common industrial fields. Human activities such as mining, processing, and transportation can release heavy metals from asbestos into the surrounding soil environment, posing a health hazard to the mining area's environment and its surrounding residents. In this study, a large asbestos mine and its surrounding soil in China were selected as the research objects. The level of heavy metal pollution in soil and sources were analyzed using methods such as the geo-accumulation index (Igeo), potential ecological risk index (RI), and positive matrix factorization (PMF) model. A Monte Carlo simulation-based health risk model was employed to assess the health risks of heavy metals in the study area's soil to human beings. The results showed that the concentrations of As, Pb, Cr, Cu, and Ni in the soil were 1.74, 0.13, 13.31, 0.33, and 33.37 times higher than the local soil background values, respectively. The Igeo assessment indicated significant accumulation effects for Ni, Cr, and As. The RI evaluation revealed extremely high comprehensive ecological risks (RI ≥ 444) in the vicinity of the waste residue heap and beneficiation area, with Ni exhibiting strong individual potential ecological risk (Eir ≥ 320). The soil health risk assessment demonstrated that As and Cr posed carcinogenic risks to adults, with mean carcinogenic indices (CR) of 1.56E-05 and 4.14E-06, respectively. Ni and Pb were considered negligible in terms of carcinogenic risks to adults. As, Cr, and Cd posed carcinogenic risks to children, with mean CRs of 1.08E-04, 1.61E-05, and 2.68E-06, respectively. Cr also posed certain non-carcinogenic risks to both adults and children. The PMF model identified asbestos contamination as the primary source of heavy metals in the soil surrounding the asbestos mining area, contributing to 79.0%, followed by coal combustion emissions (11.1%) and natural emissions (9.9%). The findings of this study can provide a scientific basis for precise risk control and environmental management of asbestos pollution at mining areas.
Hydrogen production from the methanol decomposition on the Pd(110) surface as catalyst considering the various possible reaction pathways: Theoretical study using DFT-D method
Authors: Hassak Abdellatif , Ghailane Rachida
Published: December 2023

The density of state (DOS) analysis was carried out for the two Pd(111) and Pd(100) surfaces previously studied and the Pd(110) surface which is used here to compare their reactivity and argue the choice of Pd( 110) as a catalyst in the present work. The investigation of the dehydrogenation and the adsorption mechanism of methanol on the Pd(110) surface has been performed by self-consistent periodic density functional theory with dispersion correction (DFT-D). Different adsorption sites of the relevant intermediates on the surface have been identified. It was found that CH3OH and CH2OH prefer to adsorb on the top site (t_ Pd), CH2O adsorb via O and C on the top site (t_ Pd), while CH3O, CHOH, CHO, and CO species adsorb on the bridge short site (bs_PdPd), COH and H on the hollow1 site (h1_Pd3). In addition, a complete reaction network comprising four reaction pathways was constructed and analyzed, which indicated that the initial cleavage of the C—H bond of CH3OH appears to be more favorable than the cleavage of the O—H bond on the Pd(110) surface from the point of view of activation barriers. It has been also shown that CH3OH→CH2OH→CH2O→CHO→CO is the most possible dehydrogenation pathway on Pd(110) surface. The remarkable differences in the activity and the predominant reaction pathway on Pd(100) and Pd(110) indicate that the dehydrogenation of methanol is sensitive to the orientation of the crystal planes (h k l).
Clinical Correlates of Cerebellar Injury in Preterm Infants with Surgical Necrotizing Enterocolitis
Authors: Garg Parvesh Mohan , Pittman Isabella , Taylor Charlotte , Reddy Kartik , varshney Neha , Hillegass William B. , Shetty Avinash , YI Joe , Inder Terrie , Garg Padma
Published: December 2023

Objective
Determine the risk factors of cerebellar injury in infants with surgical necrotizing enterocolitis (NEC).
Methods
Retrospective study compared clinical/pathological information between surgical NEC infants with and those without cerebellar injury.
Results
Infants with cerebellar injury (21/65, 32.3%) had significantly more hemorrhagic and the reparative lesions on the intestinal histopathology, had patent ductus arteriosus (PDA) more often, received red cell transfusion frequently, had blood culture positive sepsis and grew gram positive organisms more often and had cholestasis frequently following NEC than those without cerebellar injury. On multilogistic regression, the positive blood culture sepsis (OR 3.9, CI 1.1–13.7, p = 0.03), PDA (OR 4.5, CI 1.0-19.9, p = 0.04) and severe hemorrhage (grade 3–4)(OR 16.9, CI 2.1-135.5, p = 0.007) were independently associated with higher risk of cerebellar injury.
Conclusion
The cerebellar injury was most likely associated with positive blood culture sepsis following NEC, PDA, and severe hemorrhage lesions (grade 3–4) in infants with surgical NEC.
Novel Evolution of the Mineralocorticoid Receptor in Humans compared to Chimpanzees, Gorillas and Orangutans
Authors: Katsu Yoshinao , Zhang Jiawen , Baker Michael E.
Published: December 2023

Five distinct full-length mineralocorticoid receptor (MR) genes have been identified in humans. These human MRs can be distinguished by the presence or absence of an in-frame insertion of 12 base pairs coding for Lys, Cys, Ser, Trp (KCSW) in their DNA-binding domain (DBD) and the presence of two amino acid mutations in their amino terminal domain (NTD). Two human MRs with the KCSW insertion (MR-KCSW) and three human MRs without KCSW in the DBD have been identified. The three human MRs without KCSW contain either (Ile-180, Ala-241) or (Val-180, Val-241) or (Ile-180, Val-241) in their NTD. The two human MRs with KCSW contain either (Val-180, Val-241) or (Ile-180, Val-241) in their NTD. Human MR-KCSW with (Ile-180, Ala-241) has not been cloned. In contrast, chimpanzees contain two MRs with KCSW and two MRs without KCSW in their DBD and both contain only Ile180, Val-241 in their NTDs. Each pair of chimpanzee MRs differ at another amino acid in the NTD. A chimpanzee MR with either Val-180, Val-241 or Ile-180, Ala-241 in the NTD has not been cloned. Gorillas and orangutans each contain one MR with KCSW in the DBD and one MR without KCSW. Both gorilla and orangutan MRs contain I-180, Val-241 in their NTD. Neither Val-180, Val-241 nor Ile-180, Ala-241 are found in the NTD in either a gorilla MR or an orangutan MR. These data suggest that human MRs with Val-180, Val-241 or Ile-180, Ala-241 in the NTD evolved after humans and chimpanzees diverged from their common ancestor. These unique human MRs may have had a role in the divergent evolution of humans from chimpanzees. Studies are underway to characterize transcriptional activation of the five human MRs by aldosterone, cortisol, and other corticosteroids for comparison with each other to elucidate the roles of these MRs in human physiology.
Development of an Automatic PV-Battery-Powered Water Irrigation System Incorporated with Arduino Software for Agricultural Activities
Authors: Manfo Theodore Azemtsop , Şahin Mustafa Ergin
Published: December 2023

This study proposes a water irrigation-based solar-powered system to enhance the convenience and savings of electricity consumption from electricity generation facilities. In addition to saving the electricity to be used in the system, the aim of consuming the required amount of water depleted in the world is kept in the foreground. The study's usage areas are homegrown plants, greenhouse gardens, and in general used in many parts. The work is primarily dependent on water and solar energy. The electricity produced by solar energy enables the design elements to work. The desired electricity will be obtained from solar energy for the operation of elements such as sensors and water motors. With various programming, in which positions the sensor will work, the operating time of the engine, and the conditions necessary for its operation are prepared from the Arduino platform. The water tank provides the water needed by the plant. When the plant needs water with the response of the sensor, the water motor transfers the water to the plant as much as necessary through the pipes. The water in the tank is filled with the solenoid valve connected to the water mains. This system uses an Arduino UNO board, which contains an ATmega328 microprocessor. It is set up in such a way that it detects the moisture level of the plants and supplies water as needed. This type of system is frequently used for general plant maintenance in small and big gardens.
Dignidade e pobreza menstrual: relato de experiência da extensão universitária na saúde do adolescente
Authors: MATOS Bruna Tainá Maria Ferreira de , VERDAM Maria Christina dos Santos , SOLON Soraya
Published: December 2023

A menstruação ainda é assunto ancorado em preconceito e discriminação. As narrativas preconceituosas sobre sexualidade e menstruação dificultam a garantia dos direitos humanos das pessoas que menstruam e aumentam a desigualdade de gênero. Este trabalho relata a experiência das ações de extensão realizadas sobre dignidade e pobreza menstrual, para público adolescente, em uma escola pública de uma capital brasileira, vinculada ao Programa Saúde na Escola (PSE). Foram realizadas três frentes de trabalho: postagens em rede social, organização de campanha de arrecadação de absorventes e ação educativa presencial em escola. Houve publicação de cinco postagens na rede social com informações técnicas e linguagem acessível. Foram distribuídos kits com absorventes para comunidade escolar. Esse conjunto das ações atendeu as diretrizes da extensão universitária e fortaleceu as políticas públicas na promoção da saúde do adolescente.
Investor behaviour and investment decisions: Evidence from Pakistan Stock Exchange
Authors: Muhammad Ali  , Nayeem ul Hassan Ansari  , Bilal Ahmed Chishty  , Chin-Hong Puah  , Muhammad Ashfaq
Published: December 2023

This research aims to understand the influence of behavioural factors on investment decisions in the Pakistan Stock Exchange (PSX). This study gathered primary data using a survey-based questionnaire from 318 individual investors. The issue being investigated in this study is how behavioural elements, such as sentiment, overconfidence, over- and under-reaction, and perceived market efficiency, affect investment choices made on the PSX, with a particular emphasis on the limited predictive power of herd behaviour. The sample data were analysed using partial least square-structural equation modelling (PLS-SEM) based approach. Results indicate that financial knowledge, sentiment, overconfidence, over- and under-reaction, and perceived market efficiency significantly affect the investment decision. Interestingly, herd behaviour does not play a significant role in predicting investment decisions. However, we are certain that this study will provide a better understanding of the relationship between behavioural factors and an investor’s investment decision in Pakistan.
Human resource practices, organisational commitment and turnover intention among bank employees in Sarawak, Malaysia
Authors: Mark Kasa  , Sherrymina Kichin  , Zaiton Hassan  , Sheena Poh  , Nursyafiqah Ramli
Published: December 2023

Banking industry is becoming more competitive due to escalating bank branches every year. It has been recorded that one of the industries with highest rate of turnover is financial service sector. Employee turnover is contributed by demanding working atmosphere and burdensome workloads. High turnover rate can adversely influence bank’s performance and productivity. It has been exhibited in previous studies concerning association between human resource practices and turnover intention and the role of organisational commitment as a mediator between human resource practices and turnover intention. A total of 283 questionnaires were distributed to bank employees in Kuching, Sarawak, Malaysia. Data analysis disclosed that there is a negative relationship between human resource practices and turnover intention and organisational commitment mediates the associations. The results of the study revealed the importance of bank employers to improve its current human resource practices for boosting organisational commitment and lowering employee turnover intention. Originality/ value of this research study lies on its contribution as the first field study to be performed in Sarawak, Malaysia in relations to human resource practices on turnover intention among bank employees with mediating role of organisational commitment.
Sequential mediation analysis of workplace bullying, work-life conflict, and young employees’ outcomes in Vietnam
Authors: Hoang-Khang Du  , Hai-Ninh Do
Published: December 2023

There has been a growing focus on workplace bullying, especially in emerging countries. This study examines the impact of workplace bullying on young employees’ outcomes in Vietnamese firms. Based on the conservation of resources theory, a sequential mediation model of five constructs (workplace bullying [WPB], work-life conflict [WLC], job satisfaction [JS], work support, and negative well-being [NWB]) was studied. Data from 238 young employees of different sectors was used to test the hypothesised model. The research data were analysed using AMOS version 22 to examine the constructed hypotheses. The results confirm that bullying is, directly and indirectly, related to employees’ outcomes in terms of job satisfaction and NWB. Furthermore, the mediating effects of WLC on the relationships of bullying, job satisfaction, and NWB are confirmed. Contrary to previous research, work support did not mediate these relationships. In order to lessen the level of perceived NWB, it is essential to reduce negative acts at work as well as enhance the understanding of this phenomenon. This study contributes to the research literature on bullying in Vietnamese context, both theoretically and practically. From these findings, organisations might be beneficial from this study to reduce the level of workplace bullying. Further research could navigate which constructs could enhance young employees’ positive experience at work in the face of workplace bullying.
Strategic flexibility and consistency at manager level: The compatibility between strategic enforcement and personality traits
Authors: Heru Santosa Hadiyanto
Published: December 2023

There is an inconsistent relationship between personality traits and strategic enforcement. Strategic enforcement can be defined in two orientations, namely flexibility and consistency. This research aims to confirm the influence of personality traits on strategic enforcement in Indonesia’s financing companies. This research is important because this industry is facing stagnant growth due to changes in the business environment. Data from 242 respondents were collected using a stratified random sampling technique, and the partial least square (PLS) program was used to analyse the correlation between variables. The results showed that managers who tend toward strategic flexibility can be identified by their personality traits, such as their approach to gathering information, decision-making, and relate with the external world. However, sources of energy do not significantly influence strategic flexibility. On the other hand, strategic consistency can be identified by personality traits such as a source of energy and decision-making. However, the way of gathering information and relate with the external world did not show a significant influence on strategic consistency. Therefore, if top management requires more strategic flexibility, managers with an intuitive, judging, and thinking-oriented personality will be more aligned with this strategy. Conversely, if top management wants to implement strategic consistency, managers with introverted and feeling-oriented personality traits will be more aligned with this strategy.
Exploring the influence of social and structural support on entrepreneurial intentions among South Asian Canadian immigrants
Authors: Nadeem Akhtar  , Syed Mohammad Azeem  , Abdullah Faisal Basiouni  , Ghulam Mustafa Mir
Published: December 2023

The focus of this paper is on the perspectives people hold towards starting their businesses. An investigation was conducted on recent immigrants to Canada, the majority of whom were from South Asian nations. Subsequently, the SmartPLS 3.2.8 analysis tool was used to examine the collected data. According to the findings of the analysis, the perception of having structural support is a poor predictor of entrepreneurial intentions. Conversely, individual characteristics, such as self-efficacy and self-control, are significant predictors of entrepreneurial intentions. The results call into question immigration policies and regulations that select immigrants based on their potential for financial success rather than the businesses they intend to start themselves. The research suggests that if immigrants with high self-efficacy were provided support from their immigrant communities, they could more easily launch new businesses. This information can serve as a guide for immigration policymakers.
Population aging in terms of generational cohorts in the context of labor productivity in the Slovak Republic
Authors: Grenčíková Adriana , Španková Jana , Rigó Richard , Gullerová Monika
Published: December 2023

The aging of the population is the main global demographic trend of the 21st century and one of the main factors in the formation of supply in the labor market. This study focuses on the aging of the population, which, in the context of the labor market, represents a problem for countries to sustain economic growth. The aim is to determine, based on the analysis of available statistical data, the impact of population aging on labor productivity and the labor market in the Slovak Republic. It also seeks to define how to mitigate the effects of population aging on maintaining economic growth and social stability without raising the retirement age. The study analyzed statistical indicators, utilizing OECD population projections and linking them to macroeconomic indicators (GDP, employment). Assuming GDP growth (3%) and labor productivity (2%) per year while maintaining 70% employment in comparison with population growth presented in the OECD forecasts, there will be approximately 367,000 unfilled jobs on the labor market in the Slovak Republic. Proposed solutions include pension reforms, investment in innovation and education for increased productivity, support for families to raise birth rates, simplified employment of workers from third countries, and improved working conditions for women. Addressing women’s working conditions can help compensate for the shortage in the aging workforce when combined with other solutions.
Leading Cheese-Industry Regions on the Russian Market
Authors: Suray Natalya
Published: December 2023

The article introduces a map of Russian regions with the highest production volumes of cheese and cheese products. The author traced the production dynamics, described the current pattern of cheese consumption, and revealed the prospects for the domestic cheese industry, which proved to be a highly-profitable and promising market niche. The best practice analysis of cheese producers with the best quality rating made it possible to formulate the basic success principles for Russian cheesemakers.
Biotechnological Parameters of Semi Hard Cheese with a High Curd Scalding Temperature
Authors: Kopaneva Nadezhda , Gavrilova Natalya , Chernopolskaya Natalya
Published: December 2023

The State Strategy for Improving Food Quality through 2030 promotes the principles of healthy diet. Cheese is a high-value dairy product with a wide variety of beneficial biological activities. Its unique diversity makes it inherent part of many healthy eating patterns. Expanding the range of cheeses is an urgent task that the domestic food industry has to tackle in order to meet the goals set by the State Strategy, i. e., improving food quality and safety. The research involved raw milk (State Standard GOST 52054-2003), milk-and-protein mix developed by Milkmix Universal (St. Peterburg, Russia), and starter-culture mix purchased from LACTOFERM (Italy), which served as the main biotechnological component to improve cheese quality, safety, and shelf-life. The work was carried out on the premises of the Federal Altai Scientific Center for Agrobiotechnologies (Barnaul, Russia). The experimental data underwent mathematical and statistical processing to reveal the optimal technological production parameters for a new sort of semi-hard cheese with a high curd scalding temperature. The article introduces the new formulation, chemical composition, nutritional profile, and energy value of the new dairy product. The technology was patented (RF No. 2800825).
An Analysis of Lexical Semantic Usage Patterns in News Reports
Authors:   Dong Nam Eo-Mun-Hak-Hoi, Kim Byounghong
Published: December 2023

This study aims at reducing communication errors in linguistic expressions provided by the media. As errors in meaning could occur because of some differences in what addressers intend and what recipients interpret between news reporters and consumers even they use the same linguistic signs. This paper analyzes ‘contaminated wastewater, recycling, antinational group, communist totalitarianism’ reported in recent news and finds out their meaning. ‘Contaminated wastewater’ is used identically with such technical terms as ‘treated wastewater’ and ‘nuclear wastewater’ considering the speakers’ assessment intention. ‘Recycling’ is an everyday word but news reporters have deliberately used it to confuse readers by interpreting its meaning anew. ‘Antinational group’ is also a general term but the speakers have intentionally distorted its meaning and delivered it to spread a specifically purposeful ideology. ‘Communist totalitarianism’ is a technical term and should be used limitedly and clearly but has been used with equivocal senses by violating social character of language. Seeing these terms have been used, readers who consume news should precisely interpret specific meaning of each word the media that deliver news use. That is the way not to be deluded by distorted news. Thus, the language users should be able to look into the meaning of specific word in linguistic expressions of news, grasp the sense and analyze its accuracy.
Sensitivity analysis of estimated evapotranspiration using soil moisture content, energy balance model of SEBAL algorithm
Authors: Dai Yunzhong , Chen Kuan-yu
Published: December 2023

Evapotranspiration is the main factor of plant growth, which can be estimated using different methods. Accurate estimation of evaporation and transpiration helps in planning to meet the actual needs of the plant. In general, daily evapotranspiration depends on temperature, climate, soil moisture, plant, growth period, root length, and the texture of the root zone porous media. In this study, the moisture balance of the soil surface is simulated daily and the components of deep percolation, evaporation, irrigation, and transpiration are calculated. The obtained results have been compared with the output of the surface energy balance algorithm for land (SEBAL) algorithm to determine the energy balance on the earth's surface and to estimate evapotranspiration. Normalized objective function (NOF), Nash–Sutcliffe efficiency index, and mean absolute error were incorporated into the problem for evaluating the predicted values. The energy balance of the soil surface and the moisture balance of the root zone each have a different process in estimating the actual evaporation and transpiration, but the correlation between them was acceptable. The interval between the calculated values can be used as input data to determine the irrigation requirement.
Ecological Theology of Creation in The Perspective of The Theology of The Trinity
Authors: Babiński Jarosław
Published: December 2023

The action of God is always the action of the Trinity. Therefore, in properly interpreting theological issues, taking this truth into account is necessary. This is the reason for attempting to interpret the ecological theology of creation from a Trinitarian aspect. The analysis of biblical and theological sources provides the basis for this. The analyses carried out reconstruct the traditional issue model of the theology of creation. They develop an understanding of the relationship between God and creation. For the triune God is the model and deepest source of relationality. The essential love between the persons of the Trinity and the profound relationship of love between the Triune God and creation carries an inspiring message for the construction of man's relationship to the world according to God's design. This should constitute the essential foundation of an ecotheological praxeology.
Arborização urbana de um município do Nordeste do Brasil: frequência de espécie exótica preocupante
Authors: Abreu Maria , Pacheco Coelho Júnior Wllamo , Monteiro Luz Anne Ranielly , Oliveira Ykaro Richard , Macedo Rocha Amanda
Published: December 2023

O objetivo deste estudo foi conhecer a diversidade das espécies que compõem a arborização urbana das vias públicas do município de Picos, Piauí, Brasil. O método de inventário utilizado foi do tipo censo, de caráter quali-quantitativo, em que todas as plantas de hábito arbóreo que se encontravam no passeio público, calçadas, ruas e avenidas dos bairros foram incluídas no estudo. Nos bairros Centro, Fátima, Junco, Malva, Paroquial, Passagem das Pedras e Trizidela foram inventariados 2.214 indivíduos arbóreos pertencentes a 43 espécies, distribuídos em 39 gêneros e 20 famílias botânicas. Azadirachta indica (1.941 espécimes), Ficus benjamina (78) e Terminalia catappa (41) foram as espécies com maior número de indivíduos. Tais espécies exóticas perfazem 93,0% da arborização de Picos, caracterizando-a como monoespecífica, pouco diversa e cujas espécies são em sua maioria exóticas. Conclui-se que a cidade de Picos precisa da elaboração de sua arborização, para que a cidade tenha uma maior diversidade florística, e que haja uma conscientização da população em relação à preservação das árvores nativas, além de maior plantio dessas árvores nas vias públicas.
Honra, o guerreiro sempre ferido
Authors: Nascimento Kátia
Published: December 2023

Este ensaio trata da obra As doenças do Brasil, de Valter Hugo Mãe (2021). Nela, Mãe retrata o sofrimento de um curumim, criança indígena, da comunidade abaeté (povo criado pelo autor), fruto da violência sexual de um homem branco a uma mulher indígena, na chegada dos colonizadores ao Brasil. Nasce então Honra, que, pelo modo como nasceu, se acredita como o mal personificado e, segundo ele, o mal deve ser extirpado. Honra torna-se um guerreiro, no entanto um “guerreiro sempre ferido”. Ele encontra-se com outro – Meio da Noite, um menino negro que fugiu da escravidão –, o qual acredita ser seu igual por ter sido também violentado, pois foi escravizado pelo branco colonizador. Cada um com suas peculiaridades, eles se ajudam entre si, numa tentativa de salvar seu povo. Valter Hugo Mãe, numa narrativa sensível, conta uma história que pesa por sobre o Brasil, o seu processo de colonização. O ensaio objetiva discutir, por meio da análise das personagens, as condições de existência do protagonista ficcional Honra, o guerreiro sempre ferido, o qual acredita que na vingança conseguirá encontrar sua identidade e alcançar a plenitude como um abaeté, um povo da e para a natureza.
Learning styles in the teaching of mathematics
Authors: Bravo-Velásquez Gema Mercedes , Reyes-Ávila Jesús Orley
Published: December 2023

The purpose of the research was to determine the scientific arguments that are developed with the way students learn and how teachers teach in the area of mathematics. In this sense, the objective was to identify the learning styles in the teaching of mathematics in the Cinco de Mayo Educational Unit of the Chone Canton in the year 2023. The problem of the study arises from the need that teachers do not plan accordingly. according to the styles that students have to learn and that are often not considered when the Teacher plans his classes. The methodology was based on the quantitative approach, because it allowed the recovery, analysis and assessment of information; A type of bibliographic-documentary and field research was applied, the methods used are inductive-deductive, analytical-synthetic and statistical. The techniques we used in the research were the checklist to analyze the micro-curricular planning designs of the teachers, the interview to identify the methodologies for student learning and the observation guide to evaluate the professional knowledge of the teachers.
Evaluating the Clinical Use and Utility of a Digital Support App for Employees With Chronic Pain Returning to Work (SWEPPE): Observational Study
Authors: Turesson Christina , Liedberg Gunilla , Björk Mathilda
Published: December 2023

Background

The digital app SWEPPE (sustainable worker, a digital support for persons with chronic pain and their employers) was developed to improve the support of people with chronic pain in their return-to-work process after sick leave and includes functions such as the action plan, daily self-rating, self-monitoring graphs, the coach, the library, and shared information with the employer.

Objective

This study aims to describe the use of the smartphone app SWEPPE among people with chronic pain who have participated in an interdisciplinary pain rehabilitation program.

Methods

This is a case study including 16 people participating in a feasibility study. The analyses were based on user data collected for 3 months. Quantitative data regarding used functions were analyzed with descriptive statistics, and qualitative data of identified needs of support from the employer were grouped into 8 categories.

Results

Self-monitoring was used by all participants (median 26, IQR 8-87 daily registrations). A total of 11 (N=16, 69%) participants set a work-related goal and performed weekly evaluations of goal fulfillment and ratings of their work ability. In total, 9 (56%) participants shared information with their employer and 2 contacted the coach. A total of 15 (94%) participants identified a total of 51 support interventions from their employer. Support to adapt to work assignments and support to adapt to work posture were the 2 biggest categories. The most common type of support identified by 53% (8/15) of the participants was the opportunity to take breaks and short rests.

Conclusions

Participants used multiple SWEPPE functions, such as daily self-registration, goal setting, self-monitoring, and employer support identification. This shows the flexible nature of SWEPPE, enabling individuals to select functions that align with their needs. Additional research is required to investigate the extended use of SWEPPE and how employers use shared employee information.
PLASMAFERESIS PADA KRISIS MYASTHENIA : KASUS SERIAL
Authors: Suryani Shila , Adiyanto Bowo
Published: December 2023

Operasi kelenjar adrenal membutuhkan tim multidisiplin termasuk ahli endokrin, ahli radiologi, ahli anestesi, dan ahli bedah. Indikasi untuk operasi kelenjar adrenal termasuk tumor mensekresi hormon dan non-hormonal. Tumor yang mensekresi hormon adrenal memiliki tantangan tersendiri bagi ahli anestesi karena membutuhkan evaluasi pra operasi yang baik, kontrol hemodinamik perioperatif, koreksi semua elektrolit dan kelainan metabolik, strategi anestesi yang terperinci dan hati-hati, pengetahuan keseluruhan tentang penyakit spesifik, kontrol dan pemeliharaan fungsi adrenal pasca operasi, dan tentunya kerjasama yang baik dengan rekan-rekan lain yang terlibat.
Daya Guna Pethidin 0,1 Mg/Kgbb dan 0,2 Mg/Kgbb Intrathekal sebagai Adjuvant Bupivakain 0,5% 10 Mg dalam Mencegah Shivering pada Sectio Cesaria
Authors: Nur Hesti Kusumasari  , IG Ngurah Rai Artika  , Djajanti Sari
Published: December 2023

Pendahuluan. Shivering akibat anestesi spinal merupakan kejadian yang sering dijumpai dan dapat memberikan dampak yang kurang baik bagi pasien. Berbagai macam obat telah dihunakan untuk mencegah dan memberikan terapi shivering. Tujuan dari penelitian ini adalah untuk membandingkan daya guna pemberian pethidin 0,1 mg/kg dan 0,2 mg/kg intrathekal dalam mencegah shivering setelah

anestesi spinal pada operasi seksio sesaria.

Metode dan Penelitian. Rancangan penelitian ini adalah Randomized Controlled Trial (RCT) dengan pembutaan ganda. Subyek penelitian dilakukan pada 196 wanita hamil, usia 18-40 tahun, status fisik ASA I dan II, umur kehamilan 37-42 mg, berat badan 40-70 kg (indeks masa tubuh < 30 kg/m2), tinggi badan > 145 cm yang menjalani operasi seksio sesaria dengan anestesi spinal, yang dibagi dalam 2 kelompok. Dilakukan anestesi spinal menggunakan bupivakain hiperbarik (0,5% 10mg), pethidin 0,1 mg/kg pada kelompok A, dan pethidin 0,2 mg/kg pada kelompok B dalam volume yang sama yakni 2,5 ml.

Hasil. Data demografi, suhu ruang operasi, ketinggian blok, dan lama operasi secara umum tidak didapatkan perbedaan yang bermakna antara kedua kelompok (p>0,05), kecuali pada tinggi badan dan tekanan sistolik (p<0,05). Kejadian shivering pada kelompok A dibanding kelompok B didapatkan perbedaan yang bermakna (35,71%) vs 22,44%; p<0,05). Kejadian efek samping mual muntah pada kelompok A lebih kecil dibandingkan kelompok B (8,33% vs 22,45%) (p<0,05).

Kesimpulan. Tidak didapatkan efek samping depresi pernapasan dan pruritus dalam penelitian ini.
Awake Craniotomy Can be Done Humanly?
Authors: Tatang Bisri
Published: December 2023

“Humanly” atau berperikemanusiaan, berarti dapatkah awake craniotomy (AC) dilakukan dengan penuh rasa kemanusiaan. Tindakan yang penuh rasa kemanusiaan saat pembedahan yang dilihat dari sudut pandang anestesi pada saat dilakukan operasi otak dengan teknik awake adalah pasien bebas dari rasa sakit, cemas dan tetap nyaman selama dilakukan tindakan pembedahan walaupun pasiennya tetap sadar. Anestesi untuk AC bervariasi dari anestesi lokal ke anestesi umum dengan pasien harus bangun intraoperatif selama dilakukan mapping language dan reseksi tumor. Awake craniotomy dengan menggunakan obat anestesi lokal dan sedasi termonitor untuk operasi tumor intrakranial yang mengenai eloquent cortex merupakan suatu teknik yang dapat diterima. Dengan teknik ini dapat dilakukan mapping intraoperatif yang menyebabkan dapat dilakukan reseksi tumor yang lebih radikal serta meminimalkan morbiditas dengan memelihara jaringan yang berfungsi. 

AC adalah suatu prosedur yang mengagumkan yang tidak bisa dipercaya pada saat pertama kali. Prosedur sama dengan kraniotomi standar, dengan satu perbedaan bahwa pasien bangun selama pemetaan korteks dan reseksi tumor, pasien mampu berbicara dan bergerak normal, akan tetapi pasien tidak bangun sepanjang pembedahan, bisa tidur dalam 1–2 jam pertama, namun tidak ada rasa nyeri selama bangun. Awake craniotomy mempunyai dua keuntungan dibandingkan dengan pembedahan biasa dengan anestesi umum yaitu 1) memberikan kesempatan mapping cortex dan subcortex untuk mengurangi morbiditas neurologis dan memaksimalkan luasnya operasi, 2) untuk menghindari morbiditas akibat anestesi umum dan lebih cepat keluar dari rumahsakit. Tidak ada penelitian randomized controll yang telah dilakukan untuk mendukung pernyataan tadi, akan tetapi, pendukung teknik ini yakin akan menguntungkan untuk pasien.

Obat yang diberikan selama prosedur harus mampu memberikan level sedasi dan analgesia yang adekuat untuk pengangkatan tulang kepala, tapi harus tidak mempengaruhi testing fungsional dan elektrokortikografi.
Blok Pleksus Brakhialis Infraklavicula Vertikal Pada Close Fraktur 1/3 Tengah Humerus
Authors: Nugroho Wahyu , FRW Calcarina , Sudadi
Published: December 2023

Telah dilakukan penatalaksanaan anestesi regional berupa blok Pleksus brakialis Infraklavikula Vertikal pada seorang wanita usia 31 tahun yang didiagnosis fraktur tertutup sepertiga tengah humerus kiri dengan ASA I yang akan menjalani operasi ORIF. Pasien dipremedikasi dengan midazolam 2 mg dan fentanyl 50 mcg intravena. Blok Pleksus Brakhialis dilakukan dengan menggunakan pendekatan Infraklavikula Vertikal. Agen yang digunakan adalah lidokain 1% sebanyak 10 ml dan bupivakain 0,5% isobarik sebanyak 10 ml. Operasi berlangsung selama dua jam dengan hemodinamik pasien stabil. Pasca operasi pasien diobservasi di ruang pulih sadar selama 2 jam. Status kesadaran dan hemodinamik selama observasi baik. Skala nyeri menggunakan VAS menunjukkan angka 1-2. Pasien kemudian diperbolehkan kembali ke bangsal.