bluuebunny/crossref_metadata_2025 huggingface dataset:
Perfil clínico, epidemiológico e microbiológico dos pacientes internados no setor de cirurgia geral do Hospital Universitário da Universidade Federal do Vale do São Francisco
Authors: Amando Yasmin Bione Diniz , Medrado Bruno Saraiva Bezerra , Peres Sandra Lúcia Lodi , Soares Hugo Alessi , Naue Carine Rosa
Published: December 2020

Infecção Hospitalar é aquela adquirida após a admissão do paciente, cuja manifestação ocorreu durante a internação ou após a alta e é considerada um problema de saúde pública. Este trabalho tem como objetivo analisar o perfil clínico, epidemiológico e microbiológico de pacientes internados no setor de Cirurgia Geral no Hospital Universitário da UNIVASF, no período de março a setembro de 2018. Foi realizado um estudo retrospectivo com abordagem quantitativa, tendo como fonte de informação prontuários eletrônicos e dados disponibilizados pelo Aplicativo de Gestão para Hospitais Universitários (AGHU). As variáveis analisadas para o perfil clínico e epidemiológico foram idade, sexo, procedência, motivo de internação, período de internação, quantidade de dias de internação, necessidade de internação em Unidade de Terapia Intensiva (UTI) e a quantidade de dias que permaneceu nesta unidade, uso de antimicrobiano prévio,número de cirurgias realizadas e foco principal da infecção.Já o perfil microbiológico teve como base todas as culturas positivas. Os dados foram tabulados no aplicativo GOOGLE FORMS e sintetizados em gráficos e tabelas para análise descritiva dos dados. Foram selecionados para participar do estudo 66 pacientes com culturas positivas. Separou-se quanto ao foco da infecção, 45,5% foram de origem abdominal, 34,8% torácicas/pulmonares, 12,1% de partes moles, 4,5% mistas e 3% de infecção de ferida operatória. Dentre as bactérias mais encontradas se destacaram Acinetobacter baumannii, Escherichia coli, e Klebsiella sp. Em relação ao perfil dos isolados, no geral, pode-se observar uma elevada resistência aos antibióticos analisados. Pode-se concluir que a maioria dos pacientes foram do sexo masculino, provenientes da emergência e as infecções estão mais relacionadas ao abdômen e ao tórax.
Efetividade da mobilização neural no tratamento da dor na síndrome do tunel carpo: revisão da literatura
Authors: Dias dos Santos Emmanuel Antônio , Batista Metzker Carlos Alexandre
Published: December 2020

A Síndrome do Túnel do Carpo (STC) é responsável por grande parte das neuropatias compressivas, acometendo cerca de 1,5% a 3,5% da população mundial. Trata-se de uma condição patológica que ocorre com maior frequência em mulheres com faixa etária entre 40 e 60 anos, é relacionada com atividades laborais onde há tarefas manuais de esforço repetitivo, podendo desencadear limitações funcionais no indivíduo. O objetivo do estudo foi verificar, por meio de revisão bibliográfica, os efeitos da Mobilização Neural (MN) sobre a dor de indivíduos com STC. Foi realizada uma revisão da literatura sobre os efeitos da MN na dor de indivíduos com STC nas bases de dados Scielo, Pubmed e PeDro. Foram analisados ao todo 118 artigos, destes, cinco foram considerados de acordo com os critérios de inclusão desta pesquisa. Concluiu-se que a MN pode ser uma alternativa para o tratamento da dor em pacientes com STC. Entretanto, quando comparada a outras terapias como ultrassom, laser de baixa intensidade e cirurgia, os resultados foram similares para a melhora da dor.
Elementos teórico-metodológicos para análise dos movimentos sociais à luz de uma abordagem marxista
Authors: Teles Gabriel
Published: December 2020

O presente trabalho busca trazer uma análise teórica acerca dos movimentos sociais ancorados em diversos autores marxistas ou inspirados no marxismo. Para tanto, busca-se evidenciar as contribuições de Marx para a análise dos movimentos sociais, o conceito de movimentos sociais na perspectiva marxista e, posteriormente, inseri-la, de forma esquemática, na dinâmica da sociedade (sua relação com as lutas de classe, desenvolvimento histórico da acumulação de capital, Estado, etc.). Busca, nesse sentido, demonstrar a fertilidade do marxismo para a compreensão e análise desse importante fenômeno da sociedade moderna.
Experiências de prevenção à tortura na América Latina
Authors: Marques de Jesus Maria Gorete , Duarte Thais Lemos , Gomes Mayara de Souza
Published: December 2020

Uma das principais políticas das Nações Unidas de prevenção à tortura foi emanada pelo Protocolo Facultativo à Convenção contra a Tortura e Outros Tratamentos ou Penas Cruéis Desumanos e Degradantes. Desde o lançamento do documento em 2002, diversos países instituíram seus Mecanismos Nacionais Preventivos. Especificamente na América Latina, quatorze constituíram tal órgão, cada qual com perfis e modus operandi distintos. A proposta desse artigo é analisar como esses atores latino americanos caracterizam as violações observadas em suas rotinas de trabalho e quais proposições emitem para revertê-las. A partir da leitura de relatórios dos Mecanismos Preventivos do Brasil, do México e do Paraguai, busca-se proceder reflexões empíricas e teóricas sobre a prática de tortura e sobre as ações dispensadas para preveni-las. São muitos os pontos de divergência entre os diferentes órgãos, mas há também aspectos em comum. O mais emblemático talvez seja a forma como os entes abordam as violações de direitos ocorridas em espaços de privação de liberdade. Todos parecem se voltar em boa medida aos fatores de risco que propiciam a tortura, reforçando a perspectiva criminológica relativa aos crimes de oportunidade.
Limites a democratização do acesso ao ensino no século XXI
Authors: Esteves Lacerda Augusto Flávio , Duran Gil Aldo
Published: December 2020

O objetivo deste artigo é analisar o processo de democratização do acesso a Universidade Pública no período pós-2012. Com base no perfil socioeconômico dos estudantes das Instituições Federais de Ensino Superior de 2018 e do curso de Medicina das universidades federais de 2016, analisamos o processo de democratização com a intenção de contribuir para o debate sobre os limites, contradições e possibilidades desse processo do acesso à universidade pública. Buscamos descobrir as causas sociais que explicam as contradições inerentes a este processo, entre elas o papel da Universidade na reprodução da estrutura social de classes. Ademais, questiona a ideologia meritocrática, que legitima a hierarquia social de classes com base na justificativa do mérito pessoal e buscamos demonstrar que existem obstáculos e limites para que o processo de democratização se complete no contexto de desenvolvimento do capitalismo periférico no Brasil. 

 

Palavras-chave: Políticas educacionais. Democratização do acesso à universidade. Meritocracia. Estado burguês. Marxismo estruturalista.
Pluriatividade na agricultura familiar no compartimento arenítico da bacia hidrográfica do Rio Pirapó – Paraná/Brasil
Authors: Kawano Tsugie , Silveira Hélio , Serra Elpídio , Graça Carlos Henrique da
Published: December 2020

O presente trabalho tem como objetivo analisar as propriedades familiares pluriativas no compartimento arenítico da bacia hidrográfica do rio Pirapó – Paraná/Brasil, a fim de compreender as suas estratégias de reprodução social e econômica nesse setor da bacia, que tem como atributo o predomínio de solos de textura média e arenosa, os quais são suscetíveis à erosão e pobres em elementos químicos. Para o desenvolvimento deste trabalho, as atividades foram segmentadas em três etapas: a primeira foi sustentada em referências bibliográficas; a segunda envolveu o levantamento de dados agropecuários do Instituto Brasileiro de Geografia e Estatística; e por último foi o trabalho de campo e a elaboração dos mapas temáticos. Para a coleta de dados, foram aplicados questionários com os produtores rurais familiares da referida unidade de paisagem. A pesquisa demonstrou que, nas propriedades estudadas, o uso desses solos, que possuem pouca capacidade produtiva em função de sua característica natural, foi principalmente para a pastagem destinada à criação de gado de corte e de leite, e como essa atividade é mais rentável em extensas áreas, como estratégias de reprodução social e econômica, os produtores familiares praticam a pluriatividade.
Parallel Approaches of Utility Mining for Big Data
Authors: Dalal Vandna Dahiya and Sandeep
Published: December 2020

Utility Itemset Mining (UIM) is a fundamental technique to find out various itemsets with interestingness measures in addition to their quantity. It helps in finding valuable items that cannot be tracked with frequent itemset mining. There are many techniques to mine the itemsets based on their utilities, but the need of the hour is to mine them from larger datasets. This paper presents a brief overview of various approaches for utility mining, which mine using the parallel framework to enhance the pace of computation. The paper is concluded with a discussion on various challenges and openings in the field of parallel mining and provides away for further development of the prevailing methodologies of big data.
A Novel Mixed Wide and PSO-Bi-LSTM-CNN Model for the Effective Web Services Classification
Authors: Punitha K.
Published: December 2020

In software technology, over the diversified environment, services can be rendered using an innovative mechanism of a novel paradigm called web services. In a business environment, rapid changes and requirements from various customers can be adapted using this service. For service management and discovery, the classification of Web services having the same functions is an efficient technique. However, there will be short lengthened Web services functional description documents, having less information, and sparse features. This makes difficulties in modelling short text in various topic models and leads to make an effect in the classification of Web services. A Mixed Wide and PSO-Bi-LSTM-CNN model (MW-PSO-Bi-LSTM-CNN) is proposed in this work for solving this issue. In this technique, the Web service category‟s breadth prediction is performed by combining Web services description document‟s discrete features, which exploits the wide learning model. In the next stage, the PSO-Bi-LSTM-CNN model is used for mining Web services description document word‟s context information and word order, for performing the Web service category‟s depth prediction. Here, particle swarm optimization (PSO) is integrated with the Bi-LSTM-CNN network for computing various hyper-parameters in an automatic manner. In third stage, Web service categories, results of depth, and breadth prediction are integrated using a linear regression model as final service classification result. At last, MW-PSO-Bi-LSTM-CNN, Wide&Bi-LSTM, and Wide&Deep web service classification techniques are compared and a better result with respect to web service classification accuracy is obtained using the proposed technique as shown in experimental results.
Determinants of Job Seekers’ Decision for Migration; A Study in Big Cities in Indonesia
Authors: Amar Syamsul , Anis Ali , ni Arius , Satrianto Alpon
Published: December 2020

This study aims to analyze the influence of pull and push factors of job seekers to migrate to cities classified as big cities in Indonesia. The research variables consisted of economic infrastructure, employment opportunities, security levels, and differences in wage levels as pull factors. Meanwhile, the variables of gender, physical condition of the area, parents' occupation, migration culture, work opportunities in the place of origin served as push factors. The destination cities of migration were cities with the classification of big cities in Indonesia, which included Medan, Jakarta and Surabaya. The study population was prospective job seekers from the city of Padang, presented by students of Padang State University and Andalas University in their last semester (semester eight). Samples of each University were 4 faculties, namely, Faculty of Economics, Faculty of Social Sciences, Faculty of Engineering and Faculty Science and Mathematic.To determine the student sample size is based on a purposive sampling technique by assigning as many as 120 people in each faculty so that a total sample of 960 people, that is, around 460 respondents or 320 people for each migration destination cityparticipated in answering the questionnaires. The analytical technique followed the Logistic Regression Model. The research results showthat (a) economic infrastructure, level of security and comfort, gender, and parents' occupations were factors that influenced the decision of job seekers to emigrate from Padang City to Surabaya City; (b) employment opportunities, relative wage levels, physical condition of the area of origin are factors that influenced the tendency of job seekers to emigrate from Padang City to Medan City; (c) while the physical condition of the place of origin, parental education, migration culture and employment opportunities in the area of origin were factors that influenced the tendency of job seekers to emigrate to Jakarta. Furthermore, the cities of Jakarta and Surabaya tended to have relatively strong pull and push factors for prospective jobseekers to migrate while Medan has only relatively strong pull factors compared to the push factors.
The Effect of Training Satisfaction to Turnover Intention Mediated by Organizational Citizenship Behavior and Job Satisfaction in Employees of Bank Syariah in Jakarta
Authors: Prilyana Cindy , Aseanty Deasy
Published: December 2020

One of the Islamic banks that implements sharia principles in carrying out its operations is one of them is Syariah Bank. Companies need employees who remain or remain in the company. To anticipate Turnover Intention that can have a negative impact on employee performance and company income in training programs, the behavior of good Organizational Citizenship Behavior in the organization, and companies must pay more attention to employees so that job satisfaction can be minimized Turnover Intention arises in the intention of employee. The purpose of this study was to analyze the effect of Satisfaction Training, analyze the influence of Organizational Citizenship Behavior, analyze the effect of Job Satisfaction, analyze the effect of Turnover Intention, analyze the effect of Satisfaction Training on Turnover Intention, analyze the effect of Satisfaction Training on Organizational Citizenship Behavior, analyze the influence of Organizational Citizenship Behavior on Turnover Intention, analyzes the effect of Satisfaction Training on Job Satisfaction, and analyzes the effect of Job Satisfaction on Turnover Intention. This research was carried out on Syariah bank employees in Jakarta with the number of respondents 110 by carrying out the data analysis method of Structural Equation Model (SEM) 16.0 software. The limitations of the research in this study are only to Syariah Banks and limited to only six variables.
Threats and Emerging Developments in Cyber Security
Authors: Murugesan M. , Balamurugan P. , Santhosh J. , Arulkumaran G.
Published: December 2020

Cyber security plays a significant role in science. Data or information security is one of the crucial issues facing the world, when there is discussion about the rapidly growing cyber-crimes, the government and many corporations are taking many steps to stop such crimes. Driven by several different measures, cybercrime continues to expand day by day. In this review, the problems confronting cyber security from emerging technological advances and developments are briefly discussed and, in turn, the paper also reflects on the newest cyber security technologies, trends and other ethics throughout the cyber security field.
Fault Detection based Connected Dominating Set (FDCDS) in Fog Computing
Authors: Valeti Nagarjuna , Sharmila V. Ceronmani
Published: December 2020

The meaning of cloud computing is providing services by using the internet. From the Cloud Data Centres (CDC) the services are utilized by the cloud users. Presently (Internet of things) IOT playing the key role to improve the performance of the fog computing enabled applications. Migrating the wireless sensor networks with IOT becomes the most powerful and error free application based on the availability of the services, cloud storage, computation and these are transferred efficiently between server and cloud. Health domain is most widely affecting system in cloud computing as well as by using fog computing with IOT. The system causes various failures for providing the service continuously. Enabling the fog computing with the integration of cloud for the medical devices to transmit the patient information to the cloud storage has become the complicated for the IOT sensors continuously. This may cause the data loss and also reduce the performance of the medical device. To improve the continuous services within the cloud server. In this paper, the Fault detection based Connected Dominating Set (FDCDS) which provides the continuous services with the integration of fog computing and IOT devices with wireless sensor networks. Simulation shows the performance of the proposed system.
Secure Message Broadcasting in VANET Using RSU based Authentication and Cascade Encryption
Authors: Devi T. Kirthiga , Mohanakrishnan R. , Karthick T.
Published: December 2020

Vehicular ad-hoc networks were introduced by applying certain principles based on MANET where nodes are high mobility vehicles. Because of this mobility of vehicles topology were rapidly changing, hence Security issue will predominant in VANET. Since network is accessible from every node, any malicious node can easily targets or get access into the network. In order to eliminate this issue a RSU based authentication should be introduced. Also in order to secure the message broadcasting between nodes and eliminating certain attack like Man-In-The-Middle (MITM) attack, a cryptographic technique called cascade encryption are used to broadcast the message from one vehicle to other vehicle in a secure and efficient way. With the help these two concepts we can able to satisfy the privacy and security requirements of Vehicular ad-hoc networks in an efficient manner.
Perspektiven einer innovativen, kulturellen Filmarbeit
Authors: Koll Horst Peter
Published: December 2020

Immer mehr Stadtbibliotheken bieten ihren Nutzer*innen das Video-on-Demand-Portal filmfriend als eigenes Streaming-Angebot für Filme und Serien an. Damit schaffen sie ein filmkulturelles Gegengewicht zu kommerziellen Streaming-Diensten und erreichen erstmals auch Menschen, die traditionelle Wege der Filmrezeption (Kino, Fernsehen, DVD etc.) bislang nicht oder nur bedingt nutzen. Mit ihrem digitalen Filmangebot ermöglichen Büchereien einen erleichterten Zugang zur Filmkultur und beteiligen sich konstruktiv am sozialen Wandel in der Filmrezeption.
A new extreme value copula and new families of univariate distributions based on Freund’s exponential model
Authors: Guzmics Sándor , Pflug Georg Ch.
Published: December 2020

The use of the exponential distribution and its multivariate generalizations is extremely popular in lifetime modeling. Freund’s bivariate exponential model (1961) is based on the idea that the remaining lifetime of any entity in a bivariate system is shortened when the other entity defaults. Such a model can be quite useful for studying systemic risk, for instance in financial systems. Guzmics and Pflug (2019) revisited Freund’s model, deriving the corresponding bivariate copula and examined some characteristics of it; furthermore, we opened the door for a multivariate setting. Now we present further investigations in the bivariate model: we compute the tail dependence coefficients, we examine the marginal and joint distributions of the componentwise maxima, which leads to an extreme value copula, which – to the best of our knowledge – has not been investigated in the literature yet. The original bivariate model of Freund has been extended to more variables by several authors. We also turn to the multivariate setting, and our focus is different from that of the previous generalizations, and therefore it is novel: examining the distribution of the sum and of the average of the lifetime variables (provided that the shock parameters are all the same) leads to new families of univariate distributions, which we call Exponential Gamma Mixture Type I and Type II (EGM) distributions. We present their basic properties, we provide asymptotics for them, and finally we also provide the limiting distribution for the EGM Type II distribution.
Multivariate medial correlation with applications
Authors: Ferreira Helena , Ferreira Marta
Published: December 2020

We define a multivariate medial correlation coefficient that extends the probabilistic interpretation and properties of Blomqvist’s β coefficient, incorporates multivariate marginal dependencies and it preserves a partial ordering stronger than concordance relation. We illustrate the results in some models and provide an application on real datasets.
On quantile based co-risk measures and their estimation
Authors: Fuchs Sebastian , Trutschnig Wolfgang
Published: December 2020

Conditional Value-at-Risk (CoVaR) is defined as the Value-at-Risk of a certain risk given that the related risk equals a given threshold (CoVaR=) or is smaller/larger than a given threshold (CoVaR</CoVaR≥). We extend the notion of Conditional Value-at-Risk to quantile based co-risk measures that are weighted mixtures of CoVaR at different levels and hence involve the stochastic dependence that occurs among the risks and that is captured by copulas. We show that every quantile based co-risk measure is a quantile based risk measure and hence fulfills all related properties. We further discuss continuity results of quantile based co-risk measures from which consistent estimators for CoVaR< and CoVaR≥ based risk measures immediately follow when plugging in empirical copulas. Although estimating co-risk measures based on CoVaR= is a nontrivial endeavour since conditioning on events with zero probability is necessary we show that working with so-called empirical checkerboard copulas allows to construct strongly consistent estimators for CoVaR= and related co-risk measures under very mild regularity conditions. A small simulation study illustrates the performance of the obtained estimators for special classes of copulas.
Time to Reduce Complexity in a Data-Driven Regulatory Agenda – Perspectives on the MiFID II Best Execution Regime
Authors: Krüger Andersen Peter
Published: December 2020

The revised Markets in Financial Instruments Directive and Regulation (the MiFID II regime)

See Directive 2014/65/EU (MiFID II) and Regulation (EU) 600/2014 (MiFIR).

is one of the most comprehensive reforms of market structural and investor protection regimes the world has yet seen. The MiFID II regime will affect the European – and likely the global – market structure for years to come. Based on relevant perspectives from the revised best execution regime under MiFID II, this article suggest that it is time to reduce complexity. It is argued that unless a sufficient degree of horizontal and vertical integration of the best execution regulation takes place, the policy objectives cannot be reached. Further, it is argued that the significant data exercise that comes with the new rules only serves end-investors if a sufficient level of data consistency can be achieved. From this outset, the article emphasises the increased importance of data in today’s EU financial regulation. The article includes relevant comparisons to the equivalent US rules on best execution.
The Principle of Directive-Compliant Development of the Law and the Contra Legem Limit
Authors: Möllers Thomas M.J.
Published: December 2020

The Europeanisation of domestic law calls for a classical methodology to ‘update’ the established traditions of the law. The relationship between European directives and national law is difficult, since directives do apply, but European legal texts need to be implemented into national law. Whilst directives are not binding on private individuals, there is no direct third-party effect, but only an ‘indirect effect’. This effect is influenced by the stipulations of the ECJ, but is ultimately determined in accordance with methodical principles of national law. The ECJ uses a broad term of interpretation of the law. In contrast, in German and Austrian legal methodology the wording of a provision defines the dividing line between interpretation and further development of the law. The article reveals how legal scholars and the case-law have gradually shown in recent decades a greater willingness to shift from a narrow, traditional boundary of permissible development of the law to a modern line of case-law regarding the boundary of directive-compliant, permissible development of the law.
Effects of pulsed electric fields on sour cherry juice properties and formations of furfural and hydroxymethylfurfural
Authors: Akdemir Evrendilek Gulsun , Agcam Erdal , Akyildiz Asiye
Published: December 2020

Impacts of pulsed electric fields (PEF) on physicochemical properties, bioactive compounds, and furfural and hydroxymethylfurfural (HMF) formations were quantified for sour cherry juice (SCJ). pH, titratable acidity (TA), total soluble solids (TSS), a*, b*, chroma, and total monomeric anthocyanin content (TMAC) were not significantly affected by 0–0.0341 J/L. The initial total antioxidant capacity (TAC) significantly rose with all the PEF treatments but initial citric, malic, fumaric, oxalic, succinic (−)-epicatechin, ferrulic, gallic, luteolin, p-coumaric, and o-coumaric acids, Cy-3-sop, and Cy-3-glu did not significantly degrade with no formations of furfural and HMF. The best-fit regression models explained 60.1, 39.7, and 36.3% of variation in TAC, TMAC, and TSS, respectively. Frequency exerted a greater impact than did electric field strength (EFS) on TA, pH, TSS, total color difference (TCD), hue, chroma, TMAC, TAC, sinapic, oxalic, quinic and tartaric acids, Cy-3-glu-rut, and furfural formation. 350.9 µs, 6.78 kV/cm, and 98 Hz were pointed as optimal settings.
Anthropogenic climate change on a non-linear arctic sea-ice model of fractional Duffing oscillator
Authors: Eze Sunday C.
Published: December 2020

In this contribution, a non-linear arctic sea-ice model of fractional Duffing oscillator is given. The solution of the model was obtained using a new proposed analytical method, which is an elegant combination of asymptotic and Laplace methods. The result obtained showed that this method is a very powerful and efficient technique for finding the analytical solution of nonlinear fractional differential equation. From the analysis of the result, we observed that the impact of anthropogenic climate change on arctic sea-ice could lead to flooding in many coastal areas and low-lying island nations.
Tualang honey versus steroid impregnated nasal dressing following endoscopic sinus surgery: a randomized controlled trial
Authors: Kumarasamy Guhan , Ramli Ramiza Ramza , Singh Harvinder , Abdullah Baharudin
Published: December 2020

Objectives

Recurrence rate of nasal polyps is high following endoscopic sinus surgery. To improve the surgical outcome, steroid impregnated nasal dressing is used postoperatively We aimed to compare the effect of Tualang honey impregnated nasal dressing with steroid impregnated nasal dressing on wound healing and surgical outcomes in post endoscopic sinus surgery patients.

Methods

A prospective, randomized, controlled trial was carried out at two tertiary hospitals. 32 patients diagnosed with chronic rhinosinusitis and had underwent endoscopic sinus surgery were enrolled. The study group received 2 mL of Tualang honey nasal dressing and the control group received nasal dressing with 2 mL of triamcinolone 20 mg/mL as positive control. A 2 cm nasal dressing was placed longitudinally into the middle meatuses of both nasal cavities. Postoperative healing assessments of edema, crusting, secretions, scarring and symptoms were performed at postoperative day 7, 14, 28 and at 3 months using Sinonasal Outcome Test 22 questionnaire and modified Lund-Kennedy scoring system.

Results

There were no significant differences noted in the scores of Sinonasal Outcome Test 22 and modified Lund-Kennedy at Day 7, 14 and 28 (p>0.05) for both groups. At 3rd month, patients in the triamcinolone group had lesser symptoms and better endoscopic findings (p<0.05).

Conclusion

Tualang honey is not as effective as steroid in achieving good wound healing and surgical outcomes in post endoscopic sinus surgery patients. Thus, it is not suitable as a substitute for steroid to reduce symptoms and prevent recurrence of disease.
The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats
Authors: Gong Lei , Wang Xuyang , Pan Jinyu , Zhang Mingjun , Liu Dian , Liu Ming , Li Li , An Fengshuang
Published: December 2020

Objective

The purpose of the present study was to evaluate the role of co-treatment of rosuvastatin (RSV) and dapagliflozin (DGZ) preconditioning in myocardium ischemia/reperfusion (I/R) injury and to further investigate the underlying mechanism.

Methods

Sprague-Dawley (SD) rats (n = 25) were divided into five groups randomly: (1) Sham, (2) I/R, (3) I/R + RSV (10 mg/kg), (4) IR + DGZ (1 mg/kg), and (5) I/R + RSV (10 mg/kg) + DGZ (1 mg/kg). The I/R model was induced with 30 min of left anterior descending occlusion followed by 120 min of reperfusion.

Results

In vivo pretreatment with RSV and DGZ, respectively, showed a significant reduction of infarction size, a significant increase in the levels of left ventricular systolic pressure, and maximal rate increase in left ventricular pressure (+dp/dt
max), decrease in the levels of left ventricular end-diastolic pressure (LVEDP), maximal rate of decrease of left ventricular pressure (−dp/dt
max) and activity of cardiac enzymes of creatine kinase (CK), creatine kinase MB isoenzymes (CK-MB), and hyper-tensive cardiac troponin I compared with the I/R group. H9C2 cells were exposed to hypoxia/reoxygenation to simulate an I/R model. In vitro administration of 25 µM RSV and 50 µM DGZ significantly enhanced cell viability, upregulated the expression levels of p-PI3K, p-Akt, p-mTOR, and Bcl-2, whereas it downregulated cleaved-caspase3, Bax. TUNEL assay indicated that pretreatment with RSV and DGZ decreased the apoptosis of H9C2 cells.

Conclusion

The combination of RSV and DGZ significantly enhances the cardioprotective effects compared with RSV or DGZ alone. RSV and DGZ have the potential cardioprotective effects against I/R injury by activating the PI3K/AKt/mTOR signaling pathway.
Stand und Herausforderungen der Forschung zum Anstaltsklima im deutschen Justizvollzug – zwischen vielversprechenden Anfängen und drohender Verzettelung
Authors: Guéridon Marcel
Published: December 2020

Das Anstaltsklima ist in den letzten Jahren zunehmend Thema der Forschung auch im deutschen Justizvollzug geworden. Diese positive Entwicklung leidet jedoch bisher unter einer hohen Fragmentierung der verschiedenen Projekte und einer Reihe theoretischer, forschungspraktischer und methodischer Probleme. Diese reichen von der Frage der Definition über mangelnde Berücksichtigung von Mehrebenenstrukturen und der Beschränkung auf querschnittliche Forschungsdesigns bis hin zu Problemen der Objektivität angesichts unterschiedlicher Perspektiven. Der vorliegende Beitrag gibt eine kurze Literaturübersicht über Forschungsprojekte jüngeren Datums zum Klima im Justizvollzug in Deutschland anhand von Veröffentlichungen ab der Jahrtausendwende. Im Anschluss werden methodische und konzeptuelle Herausforderungen hervorgehoben, die mit der Erhebung und Erforschung des Klimas im Justizvollzug in Theorie und Praxis einhergehen. Aus diesen werden eine Reihe von Empfehlungen für die Klimaforschung im Justizvollzug abgeleitet und diskutiert.
“Es gibt nur eine Sprache”: The ‘Task of the Translator’ in Rosenzweig’s Idea of Language and Redemption. Its Conceptual Homologies and Expansions
Authors: De Villa Massimiliano
Published: December 2020

The concurrence of different languages is one of the tenets of Rosenzweig Sprachdenken and of his translation activity which finds its main theoretical explication in the afterword to his ‘Zweiundneunzig Hymnen und Gedichte des Yehuda Halevi’ (Konstanz, Wöhrle, 1924). In the afterword to the translation of ha-Levi’s lyrical corpus, Rosenzweig outlines a translation model which, trying to convey all the morphological, syntactic and lexical traits of the source language into the target language, gives way to a real linguistic fusion which defies the limits and boundaries of expression and opens onto a redemptive perspective. On the basis of this concluding note and of some passages from ‘The Star of Redemption’, the article tries to analyse Rosenzweig’s idea of language and of its nexus with the idea of redemption with reference to Walter Benjamin’s famous essay ‘The Task of the Translator’ and, as a point of convergence, with Paul Celan’s conception of poetic language.
Just West of East: The Paradoxical Place of the Theresienstadt Ghetto in Policy and Perception
Authors: Walch Teresa
Published: December 2020

When German authorities established the Theresienstadt Ghetto for Bohemian and Moravian Jews in late 1941, the site initially functioned much like other ghettos and transit camps at the time, as a mere way station to sites of extermination further East. The decision to reconfigure the ghetto as a site of internment for select “privileged” groups of Jews from Germany and Western Europe, and its advertisement as a “Jewish settlement” in Nazi propaganda, constituted an apparent paradox for a regime that sought to make the Greater German Reich “judenrein” (clean of Jews). This article investigates the Theresienstadt Ghetto from a historical-spatial perspective and argues that varying prejudices and degrees of antisemitism shaped divergent “spatial solutions” to segregate Jews from non-Jews, wherein the perceived divide between so-called “Ostjuden” and assimilated Western Jews played a central role. In this analysis, Theresienstadt emerges as a logical culmination to paradoxical policies designed to segregate select groups of German and assimilated Western European Jews.
Crystal structure of (E)-2-(((1H-pyrrol-2-yl)methylene)amino)-3′,6′-dihydroxyspiro[isoindoline-1,9′-xanthen]-3-one — methanol (1/2), C27H25N3O6
Authors: Song Yu-Fei , Wu Wei-Na , Wang Yuan
Published: December 2020

C27H25N3O6, triclinic, P

1
‾

$‾{1}$

(no. 2), a = 10.591(5) Å, b = 10.833(5) Å, c = 12.503(6) Å, α = 73.690(7)°, β = 88.569(7)°, γ = 60.856(6)°, V = 1191.7(9) Å3, Z = 2, R

gt
(F) = 0.0542, wR

ref
(F
2) = 0.1716, T = 296 K.
Tractatus, Application and Use
Authors: van der Does Jaap , Stokhof Martin
Published: December 2020

The article argues for a contextualised reading of Wittgenstein’s Tractatus. It analyses in detail the role that use and application play in the text and how that supports a conception of transcendentality of logic that allows for contextualisation. The article identifies a tension in the text, between the requirement that sense be determinate and the contextual nature of application, and suggests that it is this tension that is a major driver of Wittgenstein’s later ideas.
Getting in touch with children with autism: Specialist guidelines for a touch-perceiving robot
Authors: Burns Rachael Bevill , Seifi Hasti , Lee Hyosang , Kuchenbecker Katherine J.
Published: December 2020

Children with autism need innovative solutions that help them learn to master everyday experiences and cope with stressful situations. We propose that socially assistive robot companions could better understand and react to a child’s needs if they utilized tactile sensing. We examined the existing relevant literature to create an initial set of six tactile-perception requirements, and we then evaluated these requirements through interviews with 11 experienced autism specialists from a variety of backgrounds. Thematic analysis of the comments shared by the specialists revealed three overarching themes: the touch-seeking and touch-avoiding behavior of autistic children, their individual differences and customization needs, and the roles that a touch-perceiving robot could play in such interactions. Using the interview study feedback, we refined our initial list into seven qualitative requirements that describe
robustness and maintainability
,
sensing range
,
feel
,
gesture identification
,
spatial
,
temporal
, and
adaptation
attributes for the touch-perception system of a robot companion for children with autism. Finally, by utilizing the literature and current best practices in tactile sensor development and signal processing, we transformed these qualitative requirements into quantitative specifications. We discuss the implications of these requirements for future human–robot interaction research in the sensing, computing, and user research communities.
Alternative Real Value Hybrid Model for the Valuation of Reversionary Leasehold Investment Properties
Authors: Ataguba Joseph Obaje
Published: December 2020

This study is a design of an alternative real value hybrid model for the valuation of reversionary leasehold investment properties characterized by divergence in the revision period of sub-rent and head rent respectively. The development of this model commenced with a synthesis of inputs for the modified rational- and real value hybrid models, and the derivation of an equivalent cash flow multiplier for terminal investments. With exception of the generic real value model, term incomes across all other contemporary models including the alternative real value hybrid model were discounted using the equated yield. The discounted reversionary cash flows in the valuation template associated with the alternative real value hybrid model appears identical to that in the generic real value model, while exhibiting itself as a surrogate reversionary income multiplier for the modified rational, and the real value/short-cut DCF models respectively. The alternative real value hybrid model was validated as capable of producing valuations that are identical to those churned out from all the existing contemporary models for the valuation of this category of reversionary leasehold investment property. The study is a novel attempt towards redesigning the modified rational model of leasehold investment property valuation and according it a real value perspective.
La troisième dimension — De la fonction éthique et esthétique du décor dans le théâtre de machines français du XVIIe siècle
Authors: Dickhaut Kirsten
Published: December 2020

The machine theatre in France achieves its peak in the second half of the seventeenth century. It is the construction of machines that permits the adequate representation of the third dimension on stage. This optical illusion is created by flying characters, as heroes, gods, or demons moving horizontally and vertically. The enumeration indicates that only characters possessing either ethically exemplary character traits or incorporating sin are allowed to fly. Therefore, the third dimension indicates bienséance – or its opposite. According to this, the following thesis is deduced: The machine theatre illustrates via aesthetic concerns characterising its third dimension an ethic foundation. Ethic and aesthetics determine each other in the context of both, decorum and in theatre practice. In order to prove this thesis three steps are taken. First of all, the machine theatre’s relationship to imitation and creation is explored. Second, the stage design, representing the aesthetic benefits of the machines in service of the third dimension, are explained. Finally, the concrete example of Pierre Corneille’s Andromède is analysed by pointing out the role of Pegasus and Perseus.
Der Dichter vor dem Porträt. Dichtung und Malerei um die Sonetti Benedetto Varchis
Authors: Vatteroni Selene Maria
Published: December 2020

Benedetto Varchi’s Due Lezzioni not only represent the high point of the debate on the paragone between painting and sculpture, but they also bring up the question of the comparison of painting and poetry. Building his argument on their common foundation in imitation, in the second lecture Varchi advocates the superiority of poetry over painting based on its mimetic capacity. My paper investigates this topic in Varchi’s sonnets, focusing on a rhetorically consistent series of poems addressed to the painter and poet Angolo Bronzino, with whom the poet enjoyed a close friendship, and culminating in a correspondence with the medalist Domenico Poggini. In these poems Varchi renovates the Petrarchan model of Rvf 77–78 by setting up a Neo-platonically based dialectic between dentro as the domain of poetry and fuori as the domain of painting, thereby shifting the comparison from the field of their mimetic capacity to that of their glorifying and immortalizing function.
Effects of resveratrol against scattered radiation-induced testicular damage in rats
Authors: Sener Tarik Emre , Atasoy Beste Melek , Cevik Ozge , Cilingir Kaya Ozlem Tugce , Cetinel Sule , Degerli Ayşe Dagli , Sener Goksel
Published: December 2020

Objectives

To investigate the possible protective effects of resveratrol against oxidative testicular damage due to scattered radiation during pelvic ionizing radiation exposure in rats.

Methods

Rats were divided into 5 groups; control, radiation, and radiation + resveratrol therapy in early and late periods. Under anesthesia, 20 Gy ionizing radiation was applied to prostatic region. Resveratrol was administered (10 mg/kg/day) orally before ionizing radiation exposure. Animals were decapitated at the end of 1st and 10th weeks. Biochemical markers of oxidative stress; caspase-3 and sirtuin-1 protein expressions; testosterone levels were evaluated, histological examinations were performed.

Results

Significant increases in malondialdehyde, 8-hydroxy-deoxyguanosine levels, myeloperoxidase, and caspase-3 activities were observed after ionizing radiation exposure, also superoxide dismutase and glutathione activities were significantly decreased. Radiotherapy increased caspase-3 and decreased sirtuin-1 protein expressions. Resveratrol treatment significantly reversed these parameters and also reversed the decrease in testosterone levels back to control levels in late period.

Conclusion

Resveratrol showed antioxidant and sirtuin-activating properties against oxidative damage caused by scattered radiation to testis and provided hormonal protection. These results suggest that resveratrol may be an alternative protective agent on testicular tissues against the effects of scattered pelvic radiation.
Gothic Architecture on the Western Fringe of the Empire. The Church of Our Lady in Tongeren (Belgium)
Authors: Debonne Vincent
Published: December 2020

By combining carbon-14 dating of mortar, rereading known written sources and both archaeological and formal analysis, the construction history of the Gothic church of Our Lady in Tongeren can be thoroughly revised. Numerous similarities with religious architecture in Lorraine, the Rhineland, and the Meuse valley reveal the architectural historical significance of Our Lady’s church on the western fringe of the Holy Roman Empire. Inside the church, differences in design are related to the separate spaces used by canons, parishioners, brotherhoods, and the urban commune of Tongeren. The elaborate Rayonnant Gothic architecture of the eastern part of the church bears witness to the prestige associated with the church’s chapter, which claimed an episcopal past.
Realismus als Katalysator. Der Genter Altar – vom Bildsystem zum Gattungssystem
Authors: Kemp Wolfgang
Published: December 2020

The Ghent Alterpiece organizes twelve panels in horizontal registers in its closed, and 14 in its open state. This interpretation takes up three topics: the ordering of the individual panels in their horizontal and vertical display, the formal treatment of the two principal orders of Christian art – thematic (e.g., the Deesis) and narrative (e.g., the Annunciation) –, and the rise of new genres such as portrait, landscape, still life, and interior within the structure of the multipanel altarpiece. What can be identified as the driving force is the realistic mode. In a unique way it unites the whole – namely through acknowledging one single exterior source of light for every item – yet divides it at the same time by honoring the intrinsic qualities of particular objects and situations. This is the beginning of what Yirmiyahu Yovel has called “the adventure of immanence.”
Le Nôtre et les architectes. À propos de la répartition des rôles sur les chantiers du jardinier
Authors: Faisant Étienne
Published: December 2020

A great deal more than just a gardener, André Le Nôtre (1613–1700) undeniably had a background in architecture. It has nevertheless been noted that he regularly cooperated with architects whose role in the design of his gardens has led to different interpretations. Based upon hitherto unpublished documents, this article examines the respective roles of André Le Nôtre and Daniel Gittard in the creation of the gardens of Chantilly as well as the ones of the gardener and Louis Le Vau in the construction of the Grande Terrasse at Saint-Germain-en-Laye, and reevaluates of the nature of their cooperation at Vaux-le-Vicomte.
Synthesis, crystal structure and photoluminescence of a binuclear rhenium(I) carbonyl complex incorporated in a framework of a distorted salophen ligand
Authors: Vogler Arnd , Bodensteiner Michael
Published: December 2020

Re(CO)5Cl reacts with salophenH2 to yield Re(I)2(salophenH)(CO)6Cl. A crystal structure determination has shown that this binuclear complex contains two Re(CO)3 fragments which are bridged by a chloride and a heavily constrained salophenH– anion as ligands. Under ambient conditions in solution and in the solid state, the complex displays an orange emission which originates from the lowest-energy IL/MLCT triplet. In solution, this phosphorescence is completely quenched by oxygen.
Socially sustainable urban renewal in emerging economies: A comparison of Magdolna Quarter, Budapest, Hungary and Albert Park, Durban, South Africa
Authors: Nzimande Ntombifuthi Precious , Fabula Szabolcs
Published: December 2020

This study compares the social sustainability of urban renewal interventions in Hungary and South Africa. The societal and environmental challenges arising from urbanisation and the associated population growth in major urban centres around the world have increased the research and policy foci on urban sustainability and governance. While urban regeneration projects are vitally important to urban sustainability, these interventions have been widely criticised because social sustainability issues have been overlooked or ignored. Therefore, there is a need for governance practices that are applicable to different national and urban contexts. The main aim of this study is twofold: firstly, it provides a literature review on the social sustainability of urban renewal and secondly, it compares urban renewal interventions in two different geographical settings to provide recommendations about public participation and stakeholder involvement, which can contribute to increasing social sustainability of urban renewal projects. To this end, a comparative approach was adopted through the analysis of two urban renewal projects: Magdolna Quarter Programme (Budapest, Hungary) and the Albert Park (Durban, South Africa), the data for which were based on a review of secondary sources, including international literature and policy documents. It was found that although urban renewal serves a city-wide purpose (and not just a local one), the socio-economic impacts of these projects have not yet been adequately explored. Furthermore, to achieve higher urban renewal sustainability, there is a need for impact assessments (with special attention paid to the social effects) to promote public participation and empowerment.