bluuebunny/crossref_metadata_2025 huggingface dataset:
Cotidiano, alienação e estética clown em Dias perfeitos, de Wim Wenders
Authors: Oliveira Herik
Published: February 2025

A discussão fundamenta-se na análise do filme Dias perfeitos, dirigido por Wim Wenders (2023). Parte-se de resenhas e críticas sobre a obra que ou celebram nela a abertura à poética do cotidiano e da rotina ou a denunciam como escapismo, falsidade e fantasia elitista. Discute-se os limites do encantamento individual em uma cotidianidade alienada no âmbito da sociedade administrada, com o trabalho como vértice da organização da existência, incluindo do tempo livre. Defende-se a proposição de que a recepção do filme, dividida entre celebração e recusa, reflete, de modo cindido, a oscilação entre resistência e adaptação característica de um traço estético que estaria no cerne dessa obra, a saber, a “estética clown” (SILVA, 2017). Para isso, são evidenciados elementos dessa estética em Dias perfeitos. A reflexão ampara-se em contribuições teóricas de T. W. Adorno, M. Horkheimer, H. Marcuse, W. Benjamin, e outros referenciais críticos, como A. Heller e G. Lukács.
La ordenación del litoral vasco
Authors:   Gobierno Vasco, de Simón Arasti Angel
Published: February 2025

La franja litoral del País Vasco tiene una longitud superior a los 400 Kms., entre costa y riberas de rías, y en ella se asienta cerca del 65 % de la población permanente de la Comunidad Autónoma. Sobre este territorio, sumamente frágil, actúa una fuerte tensión colonizadora, por lo que ha de ser objeto de políticas de ordenación proteccionistas que aseguren también el uso y dísfrute de esta zona por parte de la mayoría de la población. Actualmente existen diversos asentamientos urbanos, en algunos casos de alta densidad y formando frentes continuos, que, sin embargo, no ocupan más del 30 % de la franja costera, lo que hace posible una política efectiva de salvaguarda y protección del litoral.
MELANOMA E NOVAS FRONTEIRAS TERAPÊUTICAS: UMA REVISÃO ATUALIZADA
Authors: Takeuti Fernanda Augusta Costa , Freitas Carla Rose de , Silva Josimar Barbosa da , Guirello Luis Arthur Moura , Huber Isabella Morais Tavares
Published: February 2025

Melanoma is the most aggressive and lethal form of skin cancer, with its global incidence increasing significantly over the past five decades. Key risk factors include genetic predisposition and environmental exposure, with ultraviolet (UV) radiation being the most significant modifiable factor. Therapeutic strategies vary according to the disease stage, ranging from surgical excision—considered the gold standard for early lesions—to more complex approaches such as immunotherapy, targeted therapy, chemotherapy, and combined regimens. Surgical excision with appropriate safety margins is essential to prevent recurrence, while in advanced stages, surgery often serves a palliative role. In recent years, the introduction of adjuvant therapies, including immunotherapies and BRAF and MEK inhibitors, has revolutionized melanoma management, significantly improving survival rates and quality of life. Additionally, the use of radiotherapy in selected cases and the development of emergent therapies broaden the treatment landscape.
A ATUALIZAÇÃO NO MANEJO DE PACIENTES COM HIPERTENSÃO ARTERIAL: ESTRATÉGIAS E DESAFIOS
Authors: Araujo Elaine Oliveira , Ribas Maria Clara Bandeira , Araujo Ana Luiza Rodrigues , Guarese Monyella Pedrosa , Santos Elton Pessoa dos , Luz Sávio Nixon Passos , Sousa Andressa Cristina Correa Machado , Ponte Ives Ribeiro , Carvalho Agesilau Coelho de , Santiago Yago Lima , Castro Cintia Marçal , Almeida Bruna Gonçalves Dantas de , Araújo Neto Aristóteles Passos , Machado Júlia Araújo , Pereira Ana Julia Lima
Published: February 2025

A hipertensão arterial é uma das condições de saúde mais prevalentes no mundo, afetando milhões de pessoas, independentemente da faixa etária, raça ou classe social. O manejo adequado da hipertensão arterial envolve uma abordagem multidisciplinar, que abrange desde a prevenção até o tratamento farmacológico e mudanças no estilo de vida. Diante desse cenário, o objetivo geral deste estudo é revisar as estratégias mais atuais no manejo de pacientes com hipertensão arterial. A pesquisa é fundamentada em uma revisão abrangente da literatura existente, para a coleta dos dados, foi utilizada a base de dados PubMed e Scielo, A pesquisa foi conduzida com os termos "Hipertensão Arterial Sistêmica”, “Estratégias Terapêuticas”, “Desafios no Manejo", aplicando o operador booleano "AND". A revisão de literatura sobre o manejo de pacientes com hipertensão arterial evidencia os avanços significativos nas abordagens terapêuticas e nas estratégias de controle da doença. A introdução de novos medicamentos e o foco na personalização do tratamento têm se mostrado essenciais para um controle mais eficaz e individualizado. Além disso, as mudanças no estilo de vida, como a prática regular de exercícios e a adoção de uma alimentação saudável, continuam sendo componentes-chave na gestão da hipertensão, embora a adesão dos pacientes a essas intervenções seja um desafio constante. Contudo, os desafios permanecem especialmente no que diz respeito à adesão ao tratamento, ao acesso a cuidados adequados e à superação de barreiras socioeconômicas. Para que os avanços no manejo da hipertensão sejam amplamente eficazes, é necessário um esforço contínuo na educação em saúde, na capacitação dos profissionais e na implementação de políticas públicas que promovam a equidade no acesso ao tratamento. A combinação de avanços científicos, tecnologias emergentes e uma abordagem multidisciplinar pode, sem dúvida, melhorar significativamente o controle da hipertensão, mas a implementação desses elementos de forma prática e abrangente ainda exige esforços consideráveis.
Brincar com Freud. O fort-da de Derrida
Authors: Corghi Veríssimo Tânia
Published: February 2025

Através do diálogo entre as leituras de Freud e Derrida, a autora pretende focalizar a brincadeira historicamente mais abordada pelos psicanalistas e pela teoria psicanalítica: o jogo do carretel, o conhecido fort-da. Derrida será tomado como autor capaz de provocar a psicanálise e os psicanalistas em sua leitura clássica da teoria freudiana, fazendo ressoar novas traduções à prática de nosso ofício. Pensaremos suas provocações como brincadeiras lançadas ao recorte teórico clássico da cena do carretel apresentado em Além do princípio do prazer. Como Freud teorizou a respeito do carretel e como nós, psicanalistas, teorizamos atualmente? Qual é nossa leitura desse brincar e como a leitura de Freud embasaria nossa prática clínica? Como Derrida, leitor questionador de padrões homogêneos de compreensão de trabalhos freudianos, o leu afinal? Em que sua tradução do fort-da infletiria sobre nossa prática? O que extrair da leitura de ambos?
Limestone Powder in Concrete Mixes: A Review of Mechanical Enhancements
Authors: Md. Saniul Haque Mahi  , Tanjun Ashravi Ridoy  , Md. Faiag Ahmed Nibir  , Mohummad Shopon Sheikh
Published: February 2025

The wide application of concrete as a construction material is also connected with a large environmental impact, mainly related to CO2 emissions from the production of Portland cement. Hence, studies increasingly investigate alternative materials that could substitute concrete, mitigating its impacts on the environment without losing its mechanical performance. Limestone powder has recently been highly considered as a supplementary constituent of concrete. This review focuses on the effects of LS on the compressive, tensile, flexural strength, and elastic modulus of concrete. Data show that it is highly affected by factors like the size of particles, dosage, and the method of application of LS in relation to its impacts on the mechanical properties of concrete. Specifically, finer LS particles can improve the compressive strength of concrete by filling the gaps and providing nucleation sites for hydration products. However, high LS concentration can cause a diluting effect that reduces compressive strength. On the other hand, LS may improve elastic modulus, tensile, and flexural strength when combined with other wastes like marble waste aggregate. These observations have explicated that LS is a workable and sustainable addition in view of performance improvement in concrete.
EPISTEMOLOGIA LACANIANA: LO UNIVERSAL, LO PARTICULAR Y LO SINGULAR EN LA CLINICA DE LAS TOXICOMANIAS
Authors: López Miguel Jesús
Published: February 2025

Puede resultar algo paradójico pensar que existe una singularidad del consumidor de drogas, si a este lo ubicamos desde la tríada de lo universal – particular – singular. Pero si llegare a ser posible ser- virse de aquel postulado enunciado en la UNESCO por Lacan (1978), donde el hacer del psicoanalista pasa por articular lo universal y lo particular, entonces lo singular se edifica como el tercero desde el cual el trabajo de interrelación de estas tres categorías puede ser puesto en el horizonte.
Jacques Lacan en junio del 1975 decía “estimo que hay aquí gente que ha leído a Aristóteles como para saber que lo singular es muy distinto de lo particular” (2022, p. 10). Allí mismo, otorgará a Aristó- teles su preferencia por lo particular.
Por lo tanto, si uno circunscribe estas categorías filosóficas a una articulación posible con el psi- coanálisis, se verá que el mismo, tanto en sus inicios por Freud como en la continuidad que promueve Lacan, que la orientación del análisis mediante lo singular es lo que siempre se terminó imponiendo, ya sea en nombre del objeto a como también por el sinthome ya hacia el final de su enseñanza, reubicando en ambos la cuestión de lo singular. Lo dice así el mismo Lacan respecto a que lo único que vale es no lo particular sino lo singular.
Pareciera entonces que una lectura psicoanalítica puede realizarse de universales como ser neu- rosis, perversión o psicosis, pero no así de un neurótico, un perverso o de un psicótico. Sin embargo, la propuesta de este trabajo ahondará en un abordaje de la singularidad del consumidor de drogas en la perspectiva de lo que al decir de Jacques-Alain Miller (AÑO) es un paradigma clínico posible que permita la articulación de la tríada universal – particular – singular alrededor de la problemática toxi- cómana.
Gender Politics and Patriarchal Oppression: A Critical Study of Female Desire in Pratibha Ray’s ‘The Stigma’ and ‘The Curse’
Authors: Pati Deepak , Dash Ashapurna
Published: February 2025

The study endeavours to inspire change in the social thought process constructed against women, highlighting the ordeals of two married women in the book Transgression and Other Stories by Pratibha Ray. The reading of two short stories, ‘The Stigma’ and ‘The Curse,’ bring out a female perspective to see the world cursed by patriarchy. Further, the analysis of the doomed fate of Sarami and Pari helps expose and denormalize the subtle, often overlooked suffering of women. With the help of Freudian findings, the study reveals that hysteria, as a disease, is largely misunderstood by people and is not even considered a problem for women who suffer from it. On the contrary, their bouts attract social ridicule, and even fellow women join hands in blaming. The need for a broader approach towards female sexuality, focusing on the dire consequences of repression of sexual desire, is realised through the study. Ray’s narrative is a critique of a minutely constructed social framework. It instills empathy in our hearts against agents of patriarchy that see the female gender as an object of victimization.
Análisis económico del Sector de la Construcción durante y después del período de pandemia
Authors: Rojas Guanoluisa Sara A.
Published: February 2025

La presente investigación tiene el propósito de dar a conocer el comportamiento del sector de la construcción durante y después de la pandemia, señalando el impacto de este sector en la economía y el PIB del país. La investigación es de método cuantitativo y cualitativo basándose en una revisión documental y con un alcance descriptivo que fue extraído de 30 fuentes; para la recolección de datos cuantitativos se consideró el análisis del estado de situación financiera de 20 empresas ecuatorianas. Los resultados demuestran un déficit en el ´índice de crecimiento del sector de la Construcción en los años de pandemia, pero también un periodo de reactivación en los años siguientes. Se concluye que en el 2020 la pandemia fue el principal factor en la reducción de la economía y por ende de los ingresos en el sector de la construcción. A pesar de este descenso imprevisto la recuperación del sector es reflejo de la relevancia que tiene a nivel social. La administración del gobierno deberá plantear estrategias pertinentes para aliviar las contingencias negativas de la crisis enfocándose en los sectores de los cuales depende el desarrollo mayoritario del país.
Betel Nut Consumption: Exploring Perceptions of Young Farmers in Natubleng, Buguias, Benguet, Philippines
Authors: Mangali Heidy B.
Published: February 2025

This ethnographic study explored the perspectives of young farmers regarding betel nut chewing. This study examines the perspectives of young farmers on betel nut chewing and explores the social factors that motivate this practice. The research reveals that betel nut chewing is not simply a habit for pleasure rather it is a habit to manifest shared beliefs and perceptions. It also serves as a means of asserting one’s social identity based on the socially constructed meaning they attach to it. The habit is revealed to be a representation of masculinity among young farmers. Moreover, betel nut chewing becomes a fulcrum of socialization among young farmers. However, the study also reveals that betel nut chewing causes some issues, leading young farmers to adopt measures such as proper oral hygiene and the use of star anise (Illicium verum) to mask bad smells. The research concludes that betel nut chewing is a complex practice driven by the beliefs and social implications attached into the habit.
Verification on Energy Digestibility in Ground Yellow Corn, Rice Bran, and Copra Expeller Fed to 10kg to 15kg Benguet Native Pigs
Authors: Simon Mineralito F. , Garcia Mary Arnel D.
Published: February 2025

Digestible and metabolizable energy contents of feed ingredients are important in swine nutrition as they directly influence feed utilization efficiency and growth performance. By accurately measuring these parameters, producers can formulate diets tailored to pigs' energy needs at various growth stages, leading to improved feed efficiency, reduced costs, and minimized environmental impacts. In this study, a digestibility trial was carried out to determine the digestible energy (DE) and metabolizable energy (ME) in ground yellow corn, rice bran, and copra expeller fed to Benguet native pigs with body weights ranging from 10kg to 15kg (102 to 127 days old) to confirm digestibility values obtained from a previous study. The total fecal collection method following the marker-to-marker approach was employed using chromic oxide as a marker to indicate the start and end of fecal collection. Ground yellow corn had 3,669 DE and 3,522 ME kcal/kg with an apparent total tract digestibility (ATTD) of 90.17%, whereas, rice bran had 4,364 DE and 4,189 ME kcal/kg with an ATTD of 84.14%. Copra expeller had 4,921 DE and 4,724 ME kcal/kg with an ATTD of 80.78%. The DE and ME values for ground yellow corn and rice bran are close to the values obtained in the previous study verified; however, values for copra expeller are different. These results are important in the establishment of feeding standards for Benguet native pigs weighing 10kg to 15kg.
Pagsusuring Retorikal at Pananaw Tungo sa Pagbubuo ng Tagline ng mga Bayan
Authors: Manaois Fely Rose B.
Published: February 2025

The study was conducted to know the strategies for creating the tagline in the different municipalities of La Union. The rhetorical aspects were analyzed based on style, lexicon, and semantics. The ideas of four groups of respondents—tourism administrators, teachers, students, and citizens, were taken by using an aide memoire. Many styles, lexicons, and meanings of the tagline of the municipalities reflect their culture and were validated by the responses of the interviewees. The styles used were powerful verbs, acronyms, translation, code-mixing, rhyming, and logo. The Iloco Code, history, and characteristics of the municipality and its populace are the lexicon. The four groups of respondents clarified that the objectives and influence of their tagline resulted in the creation of suggested strategies for formulating taglines that may be used in teaching language at the tertiary level. 
Isinagawa ang pag-aaral sa layuning malaman ang mga pamamaraan sa pagbubuo ng mga tagline sa mga bayan ng La Union. Sinuri ang mga retorikal na pamantayan batay sa estilo, leksikon at semantika. Kasabay nito ang pagkuha ng pananaw sa apat na pangkat na kinapanayam sa pamamagitan ng paggamit ng aide memoir. Marami ang estilo, pinagmulan at kahulugan ng mga tagline ng bawat bayan na sumasalamin sa kultura ng bawat isa na napagtibay sa pamamagitan din ng mga pananaw ng ibang mga pangkat na kinapanayam. Ang mga estilong lumabas ay paggamit ng pandiwang makapangyarihan, akronim, pagsasalin, code mixing, paggamit ng logo at pagtutugma. Iloco Code, kasaysayan at katangian ng bayan, at mamamayan ang pinaghanguan ng tagline. Mahalaga ang ambag na kaisipan ng mga apat na pangkat na kinapanayam dahil nagbigay ito ng linaw sa tunguhin at impluwensiya ng kanilang tagline. Daan ang mga ito upang makabuo ng mungkahing pamamaraan sa pagbubuo ng tagline na maaaring magamit sa pagtuturo ng wika bilang kongklusyon Nabuo ang mga sumusunod na rekomendasyon: magsagawa ng karagdagang pag-aaral pa tungkol sa mga tagline para makita pa ang mga pagbabagong ginagamit sa pagbuo ng mga ito; mainam din na gawing lunsaran ang mga tagline sa mga usaping panlipunan.
Ethnomathematics on the Rice Cultivation Practices in Sablan, Benguet
Authors: Yeban Jessica A.
Published: February 2025

This descriptive-interpretive design documented Ethnomathematics pertaining to rice cultivation practices in Sablan, Benguet. Interviews were conducted among the identified key informants of the indigenous people of Sablan, Benguet, identified through purposive sampling. Results showed that accounting for rice harvest involved simple counting while ciphering included posting purong in rice fields. Estimation in measuring their rice harvest was documented as a common practice. Sequential steps in cultivation include seedling preparation, land preparation, transplanting, pest control, harvesting, and drying. Harvests were categorized by variety and harvest time. Additionally, beliefs related to rice cultivation were also observed by the people of Sablan. They predict the weather based on the arrival of specific birds and the color of rice grains. Further, their planting method exhibited mathematical patterns and the sidewalls of their alang or rice granary displayed modeling patterns. Their rice cultivation practices showed the rich culture of the people which is worth documenting. Other indigenous practices may be documented to preserve the local practices. The identified ethnomathematics on rice cultivation practices may be incorporated into teaching math concepts. The community was also encouraged to participate in teaching the practices to the younger generations for cultural preservation and promotion.
Design, Fabrication, and Performance Evaluation of a Small-Scale Compost-Turning Machine
Authors: Velasco Joshua T. , Bandisa Gilbert L. , Dominguez Erickson N. , Andres Jamesly T.
Published: February 2025

A small-scale compost turning machine was designed, fabricated, and evaluated to speed up the decomposition rate of compost piles by giving optimum aeration through frequent turning, resulting in faster compost production. The designed compost turning machine mainly consists of thrower blades, a power transmission system, and prime mover, a side cover, a scraper, wheels, and a frame. The machine's design was created in AutoCAD software and fabricated in the metalwork shop. The performance evaluation of the machine at three different peripheral speeds [1090 rev∙min-1, 1276 rev∙min-1, and 1386 rev∙min-1] of the thrower blade was carried out in terms of turning capacity, turning efficiency, pulverizing efficiency, and fuel consumption. The compost turning machine operated at 1276 rev∙min-1 optimally, and has a turning capacity of 77.35 kg∙min-1, a turning efficiency of 99.79%, a pulverizing efficiency of 97.21%, and fuel consumption of 2.16 L∙hr-1. Simple cost analysis revealed that at a custom rate of 0.17 Php∙kg-1 of compost turned, the payback period of the investment is 172 days of turning operation. The break-even point is 33,923 kg∙ yr-1 with revenue of 75,741.12 Php∙yr-1 compared to manual operation with a recorded capacity of 46.67 kg∙min-1 having only revenue of Php 44,315.17 Php∙year-1.
INFLUENCE OF FACEBOOK USAGE ON ACADEMIC PERFORMANCE AMONG STUDENTS IN PUBLIC SECTOR COLLEGES OF PESHAWAR DISTRICT
Authors: Malik Kalsoom , Muhammad Tofail
Published: February 2025

Background: Social media platforms, particularly Facebook, have become deeply integrated into the daily lives of students, influencing how they interact, learn, and manage their academic responsibilities. While Facebook offers opportunities for information sharing and academic collaboration, concerns have emerged regarding its potential to disrupt study routines, affect classroom attentiveness, and negatively influence academic performance. Understanding the relationship between Facebook usage and academic outcomes is essential to developing strategies for its constructive use in educational settings.
Objective: This study aimed to investigate the impact of Facebook usage on the academic performance of female students in public-sector colleges in District Peshawar, focusing on its influence on study hours, classroom attentiveness, and overall academic outcomes.
Methods: A quantitative, descriptive research design was employed, with data collected from 400 female Bachelor of Science (BS) students enrolled in Social Sciences and Natural Sciences programs. A simple random sampling technique was used to ensure representativeness across four public-sector colleges. Data collection was conducted through self-administered questionnaires using a 5-point Likert scale. Regression analysis and descriptive statistics were applied to assess the relationship between Facebook usage, study hours, classroom attentiveness, and academic performance.
Results: Findings revealed that 65% of students acknowledged disruptions in study routines due to excessive Facebook use, while 58% reported difficulty maintaining focus during lectures. Approximately 72% believed that Facebook negatively affected their academic performance. However, regression analysis showed a weak but statistically significant negative correlation between Facebook usage and academic performance (r = -0.104, p = 0.038), with only 1.1% of academic performance variability explained by Facebook usage. Late-night usage was associated with decreased study hours and lower classroom attentiveness.
Conclusion: While Facebook provides valuable academic resources, excessive usage disrupts study routines and reduces focus, indirectly impacting academic outcomes. Educational institutions should promote responsible social media use through seminars and structured academic engagement. Future research should explore broader populations and include qualitative analyses for deeper insights.
Initial Conditions, Dynamic Capabilities and Performance.
Authors:   St. Paul's University, Mwangi Julius K. , Kiiru David ,   Kenyatta University
Published: February 2025

Every organization strives to achieve the best market position, attain a competitive edge, maintain high performance and end up being a market leader. However many firms start on the right foot but as the time progress some fall or failto achieve the same. This study looked at the role of initial condition in attaining competitive advantage as well as the overall performance. The research was a census of the commercial banks sector and the findings revealed that the initial conditions do not influence the performance though contributesgaining competitive advantage.The study looked at the moderating role of dynamic capabilities on the relationship between initial conditions and performance. The findings show initial conditions effect on performance diminisheswith time. However dynamic capabilities are found toplay moderating role in the relationship between initial conditions and performance of commercial banks in Kenya. The study recommends that all banks staff be educated on the various categories of dynamic capabilities to enable the utilize them to improvetheir performance and well as gaining competitive advantage. Keywords: Performance, Initial Conditions, Dynamic Capabilities
Effect of Preparation Conditions on the Structural and Optical Properties of CoCao3Thin Films Prepared by Chemical Bath
Authors: Z.B. Ibraheem , Mahmood Saad F. , Salih Hamid A.
Published: February 2025

Perovskite CoCaO3Thin films were deposited on glass substrates using chemical bath deposition. the effect of deposition temperature(30,70 and 85oC) and deposition periods(10,20 and 30min)on the physical propertiesof the films. The energy gap changed with deposition periods and temperatures, the energy varied from 3.35eV to 3eV with deposition period, while it was varied from 3.35eV to 2.4 with deposition temperature.x ray spectrum of the films prepared at 85oC with 10min deposition temperture show that the films are including amorphous and crystalline phases with grain size of about 52.67nm.
RED 2024 (wl 1512)-Intro-EPW Review of Environment and Development
Authors: Sharachchandra Lele  , Geetanjoy Sahu
Published: February 2025

without abstract
Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome
Authors: Wang Huei Bin , Smale Natalie E , Brown Sarah H , Villanueva Sophia Anne Marie , Zhou David , Mulji Aly , Nguyen-Ngo Kyle , Harvey John R , Ghiani Cristina A , Colwell Christopher S
Published: February 2025

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by the abnormal expansion of CGG repeats in the fragile X mental retardation 1 (FMR1) gene. Many FXS patients experience sleep disruptions, and we sought to explore these symptoms along with the possible benefits of a scheduled feeding intervention using the
Fmr1
knockout (KO) mouse model. These mutants displayed clear evidence for sleep and circadian disturbances including delay in the onset of sleep and fragmented activity rhythms with increases in cycle-to-cycle variability. Importantly, the
Fmr1
KO mice exhibited deficits in their circadian behavioral response to light with reduced masking, longer time to resetting to shifts in the Light-Dark cycle, altered synchronization to a skeleton photoperiod and lower magnitude light-induced phase shifts of activity rhythms. Investigation of the retinal input to the surprachiasmatic nucleus (SCN) with the neurotracer cholera toxin (β subunit) and quantification of the light-evoked cFos expression in the SCN revealed an abnormal retinal innervation of the SCN in the
Fmr1
KO, providing a possible mechanistic explanation for the observed behavioral deficits. Interestingly, disruptions in social and repetitive behaviors correlated with sleep duration and fragmentation. Understanding the nature of the deficits, we decided to apply a scheduled feeding regimen (6-hr/18-hr feed/fast cycle) as a circadian-based strategy to boast circadian rhythms independently of light. This intervention significantly improved the activity rhythms and sleep in the mutants. Strikingly, the scheduled feeding ameliorated social interactions and reduced repetitive behaviors as well as the levels of Interferon-gamma and Interleukin-12 in the
Fmr1
KO mutants, suggesting that timed eating may be an effective way to lessen inflammation. Collectively, this work adds support to efforts to develop circadian based interventions to help with symptoms of neurodevelopmental disorders.
Title pages and extracts from French dictionaries printed in the first half of the eighteenth century
Authors: Various French Lexicographers
Published: February 2025

The following dictionaries are included:

Antoine Furetière’s Dictionnaire universel edited by Henri Basnage de Beauval’s (1701), title page and pages with description of the Aurore, taken from the Gallica database of the Bibliothèque nationale de France.
Antoine Furetière’s Dictionnaire universel edited by Jean-Baptiste Brutel de la Rivière (1727), title page and page with description of the Aurore, taken from the Gallica database.
The “Dictionnaire de Trévoux” edited by a group of Jesuits (editions from 1704, 1721, 1732, 1743), title pages and descriptions of the Aurore, taken from the Gallica database.
The Dictionnaire de l’Académie françoise (third edition, 1740), title page and description of the Aurore Boréale, taken from the Gallica database.

For an explanation of the context, see the introductory essay by Muriel Brot and Per Pippin Aspaas.
Machine learning-based feature selection and classification for cerebral infarction screening: an experimental study
Authors: Niu Yang , Tao Xue , Chang Qinyuan , Hu Mingming , Li Xin , Gao Xiaoping
Published: February 2025

Cerebral infarction screening (CIS) is critical for timely intervention and improved patient outcomes. We investigate the application of machine learning techniques for feature selection and classification of speech and cognitive function assessments to enhance cerebral infarction screening. We analyze a dataset containing 117 patients (95 patients were diagnosed with cerebral infarction, and 54 were identified as lacunar cerebral infarction of them) comprising speech and cognitive function features from patients with lacunar and non-lacunar cerebral infarction, as well as healthy controls. In this article, we present a framework called CIS which comprises a cerebral infarction screening model to identify cerebral infarction from populations and a diagnostic model to classify lacunar infarction, non-lacunar infarction, and healthy controls. Feature selection method, Recursive Feature Elimination with Cross-Validation (RFECV), is employed to identify the most relevant features. Various classifiers, such as support vector machine, K-nearest neighbor, decision tree, random forest, logistic regression, and eXtreme gradient boosting (XGBoost), were evaluated for their performance in binary and ternary classification tasks. The CIS based on XGBoost classifier achieved the highest accuracy of 88.89% in the binary classification task (i.e., distinguishing cerebral infarction from healthy controls) and 77.78% in the ternary classification task (i.e., distinguishing lacunar infarction, non-lacunar infarction, and healthy controls). The selected features significantly contributed to the classification performance, highlighting their potential in differentiating cerebral infarction subtypes. We develop a comprehensive system to effectively assess cerebral infarction subtypes. This study demonstrates the efficacy of machine learning methods in cerebral infarction screening through the analysis of speech and cognitive function features. These findings suggest that incorporating these techniques into clinical practice could improve early detection and diagnosis of cerebral infarction. Further research with larger and more diverse datasets is warranted to validate and extend these results.
Cadmium toxicity on communities of ammonia-oxidizing microorganisms
Authors: He Huan , Dang Lina , Yang Qian , Chen Ran , Yang Jianmei , Li Jinshan , Zhu Qiang , Dai Jiulan
Published: February 2025

The oxidation of ammonia to nitrite, which constitutes the initial and rate-limiting step in the nitrification process, plays a pivotal role in the transformation of ammonia within soil ecosystems. Due to its susceptibility to a range of pollutants, such as heavy metals, pesticides, and pharmaceuticals, nitrification serves as a valuable indicator in the risk assessment of chemical contaminants in soil environments. Here, we analyzed the effects of cadmium (Cd) treatment on soil potential nitrification rate (PNR), and the abundance of ammonia-oxidizing archaea (AOA) and ammonia-oxidizing bacteria (AOB) communities. The results showed that, under 1 day incubation, the soil PNR with Cd 0.5 mg kg−1 was a little higher but not statistically significant than that with zero mg kg−1. Then, the soil PNR increased with the increasing Cd concentration from 0.5 to one mg kg−1, and continuously declined from 1 to 10 mg kg−1. Moreover, we predicted the bacterial functions of samples with hormetic Cd dose (one mg kg−1) by PICURSt (Phylogenetic Investigation of Communities Reconstruction of Unobserved States), and found that the expression of protein disulfide isomerase (PDI) increased with the hormetic Cd dose. PDI is known to enhance the activity of compounds containing –SH or –S–S which can help prevent oxidative damage to membranes. The soil PNR was significantly correlated with AOA abundance rather than AOB, even the abundance of AOB was higher than that of AOA, indicating that AOA functionally predominated over AOB. Our study effectively evaluated the Cd toxicity on soil microbial community and clearly illustrated the ecological niches of AOA and AOB in the agricultural soil system studied, which will be instructive for the sustainable development of agriculture.
Arquitetura híbrida baseada em Business Process Management, arquitetura corporativa e mineração de processos para apoiar o mapeamento e o redesenho inteligente de processos organizacionais
Authors: Romero Marcio , Gatto Dacyr Dante de Oliveira , Portellada Nityananda , Evangelista João Rafael Gonçalves , Silva Rosana Cordovil da , Sassi Renato José
Published: February 2025

A Transformação Digital integra tecnologia ao negócio, exigindo que processos sejam mapeados e redesenhados de forma inteligente. Métodos como Business Process Management (BPM), Arquitetura Corporativa (AC) e Mineração de Processos (MP) focam em gestão por processos, infraestrutura de TI e logs de eventos, respectivamente e que a aplicação desses métodos isolados não produz efeito completo. Por isso, o desenvolvimento de uma Arquitetura Híbrida (AH) que combine estes métodos pode ser uma solução ao reunir as vantagens que cada um deles possui reduzindo as suas respectivas desvantagens. Desenvolver e aplicar uma Arquitetura Híbrida baseada em Business Process Management, Arquitetura Corporativa com TOGAF e Mineração de Processos para apoiar o Mapeamento e Redesenho Inteligente de Processos Organizacionais. Caracterizada como aplicada com abordagem quantitativa e exploratória. A AH foi desenvolvida em quatro fases e aplicada em duas bases de dados. Verificou-se que os resultados da aplicação da AH reduziram o mapeamento em 60%, a quantidade de pessoas envolvidas em 50% e em 20% o tempo de retorno, quando comparados com os resultados dos métodos tradicionais. Proporcionar base para pesquisas interdisciplinares, com o objetivo de compreender como a combinação de métodos diferentes pode ampliar a área de abrangência e de aplicação. Considerar a AH como alternativa que propicia melhoria no desempenho do mapeamento e redesenho inteligente de processos, alcançando resultados e consolidando processos. Apoiar empresas para atuar em ambientes em constante mudança impactando na melhoria do atendimento das necessidades de seus clientes.
The Impact of Obesity on Prostate Cancer Aggressiveness: A Retrospective Analysis in Kiambu County, Kenya
Authors: Ondego Selvine Ouma , Odongo Alfred Owino , Njuguna Diana Wangeshi
Published: February 2025

Background: Obesity is a growing world concern, with one-third of the world’s population estimated to be obese or overweight. Obesity affects all age groups, both genders, and different ethnicities at variable rates with an increase in prevalence since 1980 having doubled.
Aim: This study aimed to evaluate obesity as a potential risk factor for the aggressiveness of prostate cancer among male patients in selected hospitals within Kiambu County i.e. Gatundu Level 5 Hospital, Kiambu Level 5 Hospital and Thika Level 5 Hospital.
Research Methods: Purposive and convenience sampling methods were employed to select patients from three hospitals: Gatundu Level 5, Kiambu Level 5, and Thika Level 5 Hospital. The study employed a convenience and purposive sampling technique to select the sample for this research. An analytical retrospective research design was used to analyze the retrospective aspect of obesity on PC among patients.
Results: This present study involved 256 patients with prostate cancer. The findings, it was revealed that there was a high level of prostate cancer aggression among men in Kiambu County, cumulative of 52.9%. The findings revealed that age (p=0.003), marital status (p=0.042), length of diagnosis (p=0.005), and stage of cancer (p=0.000) of the patients significantly influenced the aggression of prostate cancer (p < 0.05) and more than 40 percent of those with PC were above 45 years. There was a significant association between prostate cancer aggression and obesity with (p<  0.05), i.e. the association between PC aggression with ever being obese (p=0.018), patient still obese (p=0.0111), obesity contributing to PC symptoms (p=0.003), difficulty managing PC with obesity (p=0.017), and deaths due to obesity (p=0.000).
Conclusion: Understanding the implications of high aggression in prostate cancer can help guide clinical decision-making and patient education, emphasizing the importance of personalized approaches in managing this disease.
The Effect of a Combination of N, P, K and Biochar-Silica Fertilizers On CEC, C-organic, N, P, K Content of Plant and Yield of Rice on Inceptisols Jatinangor, Indonesia
Authors: Sofyan Emma Trinurani , Sudirja Rija , Sara Dirga Sapta , Damayanti Farida , Citraresmini Ania , Putri Andina Kristina
Published: February 2025

Inceptisols have enormous potential for cultivating lowland rice because of their wide distribution in Indonesia, but low fertility is one of the problems with Inceptisols. The experiment aims to determine the effect of a combination of N, P, K, and biochar-silica fertilizers on CEC, C-organic, N, P, K content of plant, and rice yields and to obtain a treatment combination that gives the best lowland rice yields on Inceptisols.  The experiment was carried out from August to November 2024 using experimental plots as experimental units and arranged in a Randomized Completely Block Design (RCBD) consisting of 10 treatments and three replications, namely 3 treatments with a combination dose of 0% N, P, K and biochar-silica, 3 treatment with a dose of 50% N, P, K and biochar-silica, 3 treatments with a dose of 100% N, P, K and biochar-silica, and 1 control treatment. The experimental results showed that the combination of N, P, K, and biochar-silica fertilizers could influence CEC, organic C, P, K element content in plants, and rice yield, but did not have a significant effect on plant N content.   Treatment N, P, K (175 kg ha-1 Urea, 25 kg ha-1 SP-36, and 25 kg ha-1 KCl) and dose of biochar (2.5 ton ha-1) + silica 320 kg ha-1 is the treatment with the best dose in increasing the yield of harvested dry grain (GKP) for lowland rice, namely 3.37 kg plot-1.
Influence of Intra-Household Gender Dynamics on Household Vulnerability to Climate Change: Empirical Evidence from Tripura State of North-East India
Authors: Debnath Ritesh , Devarani Loukham
Published: February 2025

Aim: The study aims to determine how intra-household gender dynamics affect women’s vulnerability to climate change at the household level in the West Tripura district.
Study Design: The study followed an ex-post facto research design, with data collected through a survey and analyzed using descriptive and inferential statistics.
Place and Duration of Study: The study was conducted in the West Tripura district of Tripura which is the most vulnerable district to climate change. Primary data were collected from April to June 2023.
Methodology: Through multistage sampling, a total of 60 households were selected for the study of which 49 were male-headed households and 11 female-headed. All male-headed households had both a primary man and a primary woman member; whereas the female-headed households had only a primary woman member. Therefore, a total of 49 primary men and 60 primary women were selected which resulted in a total number of 109 respondents for the present study. For calculating the Household Livelihood Vulnerability Score (HLVS) of the individual, the components of the Livelihood Vulnerability Index (LVI) approach were adapted with necessary modifications to suit local context.  
Results: There was a greater number of households where only the primary men had adequacy in the selected empowerment variables while there was a comparatively lesser incidence of women achieving adequacy. The annual household income of male-headed households was higher than the female-headed households by 30.38 %. The contribution of women in the household income of male-headed households averaged just 9.65 %. Variables such as income of primary women, primary women's contribution to household income, and household head had a positive and significant relationship with the HLVS at a 1 percent level of significance. Women-headed households had significantly higher HLVS than men-headed households across all the selected empowerment variables.
Conclusion: The findings revealed a significant impact of intra-household gender dynamics on households’ vulnerability to climate change, implying that any vulnerability reduction approaches such as gender-inclusive climate action should address this dimension in the future.
On the distribution of ligands within the asymmetric chaperonin complex, GroEL14 · ADP7 · GroES7
Authors: Girshovich Alexander S. , Bochkareva Elena S. , Todd Matthew J. , Lorimer George H.
Published: July 2002

In the presence of MgATP or MgADP the E. coli chaperonin proteins, GroEL and GroES, form a stable asymmetric complex with a stoichiometry of two GroEL7:one GroES7: seven MgADP. The distribution of the ligands between the two heptameric GroEL rings is crucial to our understanding of the mechanism of chaperonin‐assisted folding, being either cis (i.e. [GroEL7·MgADP7·GroES7]‐[GroEL7]) or trans (i.e. [GroEL7· MgADP7]‐[GroEL7·GroES7]. On the basis of cross‐linking experiments with 8‐azido‐ATP and the heterobifunctional reagent, N‐succinimidyl 3‐(2‐pyridyldithio) propionate (SPDP), it was suggested that GroES and MgADP are bound to the same GroEL ring which resists proteinase K digestion [Nature 366 (1993) 228–233]. However, we find that the SPDP‐promoted cross linking of GroES and GroEL occurs in the absence of Mg2+, ADP or ATP, which are required for the formation of the asymmetric complex. Cross‐linking is shown to occur only when the SPDP‐modified GroES is co‐precipitated with GroEL by trichloracetic acid. Furthermore, there are structural grounds for questioning whether SPDP can crosslink, in a physiologically relevant manner, an amino group of GroES with any of the cysteinyl groups of GroEL.
Postmenopausal bone loss in Japanese women
Authors: Mizuno K. , Suzuki A. , Ino Y. , Asada Y. , Kikkawa F. , Tomoda Y.
Published: July 2002

Objectives: Our purpose was to detect anatomic variations in postmenopausal bone loss and to determine the risk factors most affecting bone mass in Japanese women. Methods: One hundred sixty‐six Japanese women (54 premenopausal and 112 postmenopausal), aged 40–68 years, were enrolled in the study. Bone mineral densities (BMD) of the lumbar spine (L2–4) and total body were measured by dual energy X‐ray absorptiometry and the results were subjected to statistical analysis. Results: Among the various sites studied, the lumbar spine (L2–4) showed the fastest bone loss after menopause. Multiple regression analysis indicated that two factors, number of years since the menopause and body mass index (BMI), affected lumbar spine (L2–4) BMD. Conclusion: Measurement of lumbar spine (L2–4) BMD is suitable for evaluating postmenopausal osteoporosis. The risk factors for postmenopausal bone loss were a long period after menopause and a low BMI.
In situ reverse transcription‐polymerase chain reaction. Applications for light and electron microscopy
Authors: Morel Gérard , Berger Martina , Ronsin Brice , Recher Sophie , Ricard‐Blum Sylvie , Mertani Hichem C. , Lobie Peter E.
Published: July 2002

Since its discovery in 1986 by Mullis, the polymerase chain reaction (PCR) has been extensively developed by morphologists in order to overcome the main limitation of in situ hybridization, the lack of sensitivity. In situ PCR combines the extreme sensitivity of PCR with the cell‐localizing ability of in situ hybridization. The amplification of DNA (PCR) or a cDNA (RT‐PCR) in cell or tissue sections has been developed at light and electron microscopic levels. A successful PCR experiment requires the careful optimization of several parameters depending on the tissue (or of cell types), and a compromise must be found between the fixation time, pretreatments and a good preservation of the morphology. Other crucial factors (primer design, concentration in MgCl2, annealing and elongation temperatures during the amplification steps) and their influence on the specificity and sensitivity of in situ PCR or RT‐PCR are discussed. The necessity to run appropriate controls, especially to assess the lack of diffusion of the amplified products, is stressed. Current applications and future trends are also presented.
Seasonality in Canadian treasury bond returns: An institutional explanation
Authors: Athanassakos George , Tian Yisong Sam
Published: July 2002

This paper empirically investigates the seasonality in quarterly bond returns in the Canadian government bond market. Four equally weighted bond return indices were calculated for each quarter in the period from 1963:Q2 to 1990:Q3. The seasonality in these quarterly returns was tested and the results support the existence of seasonality in quarterly bond returns in the Canadian government bond market. It appears that bond returns in the last quarter of the year are significantly higher than in any other quarter of the year. This finding contrasts to the results in U.S. studies on Treasury bond returns. An institutional explanation is offered for the documented seasonality in bond returns, linking it to the annual Canada Savings Bond campaign in the last quarter of the year, a unique Canadian phenomenon. This hypothesis is supported by empirical evidence based on a regression analysis. Such finding is consistent with the fact that no seasonality in Treasury bond returns is found in the U.S., at the U.S. Savings Bonds are sold regularly throughout the year.