bluuebunny/crossref_metadata_2025 huggingface dataset:
Aplikasi Pemberian Pupuk Organik Cair NU-POC Dan Bio Sugih Terhadap Pertumbuhan Tanaman Bayam Merah (Amaranthus tricolor L.)
Authors: Lia Nora Feby , Laili Saimul , Tito Sama' Iradat
Published: January 2025

Red spinach is one of the most popular vegetable commodities because it has high nutritional value. Amaranthus tricolor L. consists of two varieties: Blitum album and Blitum rubrum. This study aims to analyze the effect of the type and concentration of liquid organic fertilizer, as well as the interaction of liquid organic fertilizer on the growth of Red Spinach Plants (Amaranthus tricolor L) in order to find the right type and concentration of liquid organic fertilizer for better growth and production of Red Spinach Plants (Amaranthus tricolor L.). This research used Experimental Randomized Design with 12 treatments and control factors. The treatment consisted of POC Bio Sugih and NUPOC. Started from control, 5, 10, 15, and 20 ml or ml/litre water with 3 times repetitions. The variables observed in this study included plant height, leaf area, number of leaves, dry weight and wet weight and abiotic factors such as soil pH, air temperature, and air humidity. This study used a one-way ANOVA test to determine the presence of 1 significant difference in each treatment and then continued with a 5% BNT test. This study showed that the administration of POC Bio Sugih with a concentration of 20 ml/litre of water significantly affected the variables of plant height, leaf area, number of leaves, wet weight, and dry weight. 
Keywords: POC Bio Sugih, NU-POC, Amaranthus tricolor L.
Bayam merah termasuk salah satu komoditi sayuran yang digemari banyak masyarakat, karena mempunyai nilai gizi yang tinggi. Jenis bayam Amaranthus tricolor L. terdiri dari dua varietas, yaitu Blitum album dan Blitum rubrum. Tujuan penelitian ini adalah untuk menganalisis pengaruh jenis dan konsentrasi pupuk organik cair, serta interaksi pupuk organik cair pada pertumbuhan dan hasil tanaman bayam merah (Amaranthus tricolor L.) guna menemukan jenis dan konsentrasi pupuk organik cair yang tepat untuk tanaman bayam merah (Amaranthus tricolor L.) dengan hasil yang baik. Dalam penelitian ini menggunakan Rancangan Acak Lengkap (RAL) faktorial dengan 2 faktor perlakuan dan kontrol. Perlakuan 1 yaitu POC terdiri dari POC Bio Sugih dan NU-POC, perlakuan 2 yaitu konsentrasi dimulai dari kontrol, 5, 10, 15, dan 20 ml atau ml/liter air dengan 3 kali pengulangan. Variabel yang diamati pada penelitian ini diantaranya tinggi tanaman luas daun, jumlah daun, berat kering, dan berat basah dan faktor abiotik seperti pH tanah, suhu udara, kelembaban udara.  Penelitian ini menggunakan uji ANOVA satu arah untuk mengetahui adanya 1perbedaan 1yang 1nyata 1pada setiap1perlakuan lalu dilanjut 1uji BNT 5%. Hasil penelitian ini menunjukkan bahwa pemberian POC Bio Sugih dengan konsentrasi 20 ml/liter air berpengaruh nyata terhadap variabel tinggi tanaman, luas daun, jumlah daun, berat basah, dan berat kering. 
Kata kunci: POC Bio Sugih, NU-POC, (Amaranthus tricolor L.)
PKM Kelas Luar Ruang dan Sosiologi Pendidikan: Menggunakan Sekolah sebagai Sumber Belajar di SMAS Islam Guppi Kota Sorong
Authors: Rais Lukman , Ramli Umar , Christy Wanma Januari , Mardliyah Uswatul , Halik Wahyudin , Sofyan Abu , Salmawati Salmawati
Published: January 2025

Pengabdian masyarakat ini bertujuan untuk mengimplementasikan metode pembelajaran luar ruang ke dalam mata pelajaran Sosiologi Pendidikan di SMAS Islam Guppi Kota Sorong. Mahasiswa berperan sebagai fasilitator dalam proses desain dan pelaksanaan pembelajaran berbasis observasi dan eksplorasi lingkungan sekolah sebagai sumber belajar. Kegiatan ini dilakukan pada bulan November 2024. Pengabdian ini bertujuan untuk membantu mahasiswa memahami konsep seperti stratifikasi sosial, mobilitas sosial, dan peran institusi pendidikan dalam kehidupan sehari-hari. Metode pelaksanaan pengabdian ini bersifat partisipatif dan berbasis pengalaman dengan penentuan sekolah mitra,  observasi, diskusi dan wawancara, kegiatan kelas luar ruang, refleksi dan analisis sosial. Hasil pengabdian ini menunjukkan bahwa mahasiswa mendapatkan pengalaman langsung dalam merancang dan menerapkan pendekatan pembelajaran yang inovatif. Mahasiswa juga belajar keterampilan praktis seperti komunikasi, manajemen kelompok, dan pemecahan masalah, dan memperluas pengetahuan mereka tentang masalah pendidikan lokal di Kota Sorong. Pengabdian ini meningkatkan kemampuan akademik dan profesional mahasiswa sebagai calon guru. Kegiatan ini menunjukkan bahwa pengembangan metode kelas luar ruang perlu dilakukan secara terus menerus di SMAS Islam Guppi dan di institusi pendidikan lainnya. Kekurangan pada pengabdian ini keterbatasan waktu pelaksanaan dan penggunaan teknologi digital untuk mendukung pembelajaran berbasis proyek, pelibatan lebih banyak sekolah.
Neuroinflammation in the acute phase after subarachnoid hemorrhage
Authors:   , Koopman Inez
Published: January 2025

A subarachnoid haemorrhage from a ruptured aneurysm is a severe type of stroke that affects approximately 1000 patients every year in the Netherlands. Neuroinflammation is one of the mechanisms that may contribute to brain damage after the haemorrhage. In this thesis, we conducted various studies to investigate the inflammatory response in the brain after aneurysmal subarachnoid haemorrhage (aSAH). We show that two types of cells, microglia and astrocytes, become activated after aSAH. These cells may provide a therapeutic target in the future as they may play a role in the development of brain damage. We also show how white blood cells counts change in the cerebrospinal fluid after aSAH. Such knowledge may help to interpret cerebrospinal fluid parameters in patients if nosocomial bacterial meningitis or ventriculitis is suspected. Subsequently, we set-up a clinical trial to investigate the safety and efficacy of eculizumab, a complement C5 inhibitor, in patients with aSAH. The primary outcome was a ≥ 55% decrease in C5a concentration in the cerebrospinal fluid of aSAH patients. Patients who received eculizumab did not have a ≥55% decrease in C5a levels in the cerebrospinal fluid. The study did not reveal new safety concerns, except for a C. albicans drain-related infection. Lastly, we asked patients and family members how consent to participate in an acute care trial should be asked. In certain circumstances, it was considered acceptable by patients and family members to first enrol a patient into a study and ask for consent in a later phase. Altogether, the results of each of these studies contribute to better understand neuroinflammation after a subarachnoid haemorrhage. In addition, the results help us understand how clinical trials can be conducted in acute conditions.
Optimizing survivorship care
Authors:   , de Beijer Ismay Anna Elisa
Published: January 2025

Each year, 400,000 children and adolescents up to the age of 19 are diagnosed with cancer worldwide. In high-income countries, more than 80% of these patients survive, thanks to advancements in treatment. However, many survivors face long-term health problems. These problems can include, for example, heart disease, fertility problems, and the development of secondary cancers. Within 30 years of their initial diagnosis, 75% of survivors will experience at least one chronic condition, with 25% of these being severe or life-threatening. This underscores the critical importance of high-quality follow-up care for childhood cancer survivors. Unfortunately, such care is often inadequate globally, hindered by gaps in knowledge, awareness, and a lack of standardized long-term care protocols.

This thesis offers four solutions to optimize survivorship care:
1. More knowledge: Our research shows that survivors have three times more health problems than their siblings without cancer. Hormone problems are especially common. This indicates that long-term, specialised care is needed.

2. New guidelines: We have developed European guidelines to better monitor survivors for health problems after their treatment up to 5 years after cancer diagnosis.

3. SurPass: This digital care plan provides personalized care and is designed to improve long-term survivorship care in Europe. The research in this thesis showed how implementation could be improved, for example through access to medical records and more time for preparation.

4. Healthy behaviors: Finally, a systematic review in preparation for a health promotion guideline shows that many survivors struggle with adopting and maintaining healthy behaviours, such as sufficient physical activity and a healthy diet. Barriers such as fatigue and time constraints require targeted support and guidance.
The findings of this thesis are helping to optimize the long-term care of survivors. This thesis provides more knowledge, better guidelines and digital tools. All this contributes to a better quality of life for survivors, in the Netherlands and abroad.
Snacks and the City
Authors:   , Hagemans Iris Willemijn
Published: January 2025

From the products on display in shopwindows, to the smells emitting from food stores and the sidewalk ballet of entrepreneurs and their patrons, consumption spaces offer a glimpse into the soul of the city. Beyond providing daily goods and services, they are spaces that represent the local character and signify who belongs there. Over the past decade, cities all over the world have witnessed a growing perception that consumption spaces are increasingly tourist-oriented, presenting a growing offer of attractions, souvenirs and – seemingly most resented– snacks. The fact that this shift fueled resistance to tourism has been particularly evident in Amsterdam, where opposition to tourist shops gained significant media attention and prompted the city government to intervene.

In this dissertation, Urban Geographer Iris Hagemans explores the material changes to Amsterdam’s inner city consumption spaces in response to increasing tourism, their interpretation in the local public debate and the policy strategies formulated to curtail touristification of consumption spaces. Guiding readers through the diverse consumption spaces of Amsterdam's inner city—from haberdashery shops and cheese stores to waffle stands and vintage boutiques—Hagemans identifies the microgeographies of touristification in consumption spaces and critiques the disconnect between these nuanced realities and the broad generalizations dominating public debates and city-wide policies.
From User Experience to Data-Driven
Authors:   , Brigitha Leiah Jane
Published: January 2025

My thesis explores the optimization of asparaginase treatment for children with acute lymphoblastic leukemia (ALL) by integrating clinical data and advanced modeling techniques. Asparaginase, an enzyme that depletes L-asparagine—essential for ALL cell survival but not for healthy cells—plays a critical role in therapy. Its efficacy, however, is influenced by factors like hypersensitivity reactions, inter and intra-individual differences in pharmacokinetics, and dosing schedules.

My research highlights that initiating treatment with PEGasparaginase, a pegylated formulation, reduces hypersensitivity compared to non-pegylated versions. Continuous, break-free dosing schedules further lower hypersensitivity risks without compromising treatment outcomes. In contrast, interruptions increase antibody development and adverse reactions.

Pharmacokinetic studies in infants confirmed that standard dosages effectively achieve therapeutic asparaginase activity without age-based adjustments. In the central nervous system (CNS), PEGasparaginase was less effective at depleting cerebrospinal fluid (CSF) L-asparagine, though CNS relapse rates remained unchanged, suggesting that complete CSF depletion may not be essential.

Alternative strategies for patients with PEGasparaginase hypersensitivity were investigated, demonstrating that E. coli asparaginase could be effective if PEG-specific antibodies are the primary issue and therapeutic drug monitoring is available. A new dosing guideline, developed using pharmacokinetic modeling, achieved target asparaginase activity more consistently with fewer dose adjustments, improving safety and efficacy.

Finally, a comprehensive review showed that while maintaining therapeutic asparaginase levels is crucial, extending exposure durations or increasing dosages beyond therapeutic thresholds does not improve outcomes. This thesis establishes actionable recommendations to refine asparaginase protocols, enhance safety, and optimize treatment for children with ALL.
Extracellular vesicles as drug delivery systems
Authors:   , Elsharkasy Omnia
Published: January 2025

RNA therapeutics play a pivotal role in the treatment of various diseases by modulating disease-related gene expression. These therapies utilize RNA sequences to regulate the expression or activity of target proteins. While RNA therapeutics hold immense potential, particularly for addressing undruggable targets, their clinical application is hindered by the challenge of efficiently delivering RNA into the cell cytoplasm, which requires overcoming both extracellular and intracellular barriers. To address these obstacles, various engineered delivery vehicles have been explored to protect and deliver RNA. Among these, extracellular vesicles (EVs) have emerged as a promising drug delivery system. EVs are a heterogeneous population of membrane-enclosed vesicles secreted by cells into extracellular spaces. Their unique properties—biocompatibility, ability to traverse biological barriers, and reduced immunogenicity—make them attractive candidates for drug delivery. Moreover, EVs exhibit higher efficiency in RNA delivery compared to state-of-the-art lipid nanoparticles. To fully harness EVs for RNA therapeutics, it is crucial to understand the molecular pathways underlying EV-mediated functional RNA delivery. In this thesis, we focus on the role of integrins in EV-mediated RNA delivery and uptake, as they play a major role in cell signaling and are involved in various physiological processes. Specifically, we show that alpha4beta1 integrin mediates functional RNA delivery and EV uptake via binding to fibronectin on the EV surface. Additionally, we investigate the role of T-cell immunoglobulin and mucin domain 1 in EV-mediated functional RNA delivery. In later chapters, we explore various methods to enhance the loading efficiency of cargo inside EVs. We describe a novel modular platform for EV-mediated loading and delivery of various gene-editing tools, including Cas9-sgRNA ribonucleoprotein (RNP) complex, transcriptional activator dCas9-VRP, and Cas9 base editor ABE8e. Moreover, we engineer a microRNA backbone to actively load siRNA inside the EVs’ lumen.
Epitranscriptomic regulation in immunity and autoimmune disease
Authors:   , van Vroonhoven Ellen Catharina Nicolasina
Published: January 2025

The immune system protects the human body against pathogens such as viruses, bacteria, and parasites. It has innate and acquired components, which together recognize and eliminate these threats. When the immune system mistakes the body's own materials for pathogens, autoimmune diseases can occur.

Immune cells, including T-helper cells (CD4+ T cells) and monocytes, play crucial roles in pathogen recognition, immune activation, and signaling molecule production. T-helper cells activate other immune cells through co-activation molecules like ICOS, CD28, and CD40L, while monocytes are involved in phagocytosis and regulating immune responses.

RNA molecules labeled with m6A modification are key in regulating immune cell function. Proteins such as FTO and METTL3 modulate the presence of m6A on RNA, influencing gene expression and immune activation. m6A modifications impact the production and secretion of signaling molecules like TNF, which are critical in immune responses and autoimmune diseases.

Research detailed in this thesis highlights the importance of m6A in:
- Activating T-helper cells by regulating CD40L expression.
- Modulating TNF production in T-helper cells and monocytes.
- Controlling immune cell activation and antiviral responses against respiratory syncytial virus (RSV).
- Influencing autoimmune diseases like juvenile idiopathic arthritis through altered expression of FTO and m6A labeling.

These findings offer potential therapeutic targets for treating immune-related diseases and viral infections by manipulating m6A-regulating proteins.
Genotype-dependent glycoproteoforms of histidine-rich glycoprotein illustrate the fine-tuning of the plasma proteome
Authors:   , Zou Yang
Published: January 2025

In the research chapters of this thesis, I focus on possible variants of glycoproteins and in particular HRG. By using primarily MS. I investigated the natural occurrence of sequence variants, and variants in glycosylation. In more details:
In Chapter 2, I review how the recombinant production of glycoproteins in various host expression systems affects their glycosylation. These N-glycosylation profiles vary due to the different abundance and activity of the palette of glycotransferases present in the host cell lines. This review highlights the importance in choosing the right host system for recombinant protein production, especially when making biopharmaceuticals, including monoclonal antibodies.
In Chapter 3, I explore potential relationships among HRG allelic variants in 44 human plasma HRG samples by using peptide-centric LC-MS/MS methods. Our proteomics data as well as genomics data retrieved from the 1000 Genome project show that several mutations of HRG are mutually exclusive, while other combinations have elevated frequencies of occurrence. The observed variability is related to ethnicity and global spread in population.
In Chapter 4, I investigate in detail the glycosylation of endogenous HRG purified from human plasma and recombinant HRG samples expressed in human HEK293 cells. The latter were produced with selected combinations of allelic mutations. The work clearly shows that HRG N-glycosylation profiles vary between plasma and the HEK293 expression systems. We also uncover a novel O-glycosylation site, that could be pinpointed by using EThcD fragmentation. In addition, we show in this chapter that sialylation of HRG and the rs9898 mutation influence HRG cleavage by plasmin.
Finally, in Chapter 5, I explore the relationships between HRG allelic variations, glycosylation, and inhibition of Factor XII autoactivation. Interestingly, HRG glycosylation (sialylation) can significantly protect FXII autoactivation from HRG inhibition, while mutation had minimal effects.
MODERN UKRAINIAN WOMEN IN THE ARMY: REALITIES AND PROSPECTS
Authors: GRABOVSKA IRYNA , VLASOVA TETIANA , NASTOIASHCHA KATERYNA , TOVMASH DMYTRO
Published: January 2025

The article is devoted to the analysis of the problem of servicewomen in the Armed Forces of Ukraine, the realities of war in the gender dimension, the prospects of women in the army, and the issue of the leadership of servicewomen in Ukraine. The issue is extremely relevant today due to Russia's military aggression against Ukraine. The authors aim to find out the prospects of Ukrainian women in the Armed Forces, including leadership positions of Ukrainian women in the army following the example of NATO and a number of countries all over the world. There are already about 8,000 female officers in command positions in the Armed Forces of Ukraine. It is noted that modern Western Europe demonstrates a tolerant attitude towards women who serve in the military forces or participate in armed conflicts as warriors. It is considered effective to use the synergy of women and men on the battlefield to achieve military goals. The article analyzes both the attitude of modern Ukrainian society to women warriors and the reactions and experiences of the women warriors themselves, who are well-known to the Ukrainian public. In conclusion it is stressed that a qualitatively new state of the Ukrainian army has been formed, in particular, thanks to the active participation of women.
L’invisibilità della traduzione: la letteratura anglosassone nei libri di testo di italiano
Authors: Giusti Simone , Nocentini Viola
Published: January 2025

I manuali scolastici attualmente in uso nella scuola secondaria di primo gra- do per lo studio dell’italiano come L1 antologizzano numerosi brani narrativi e opere poe- tiche in traduzione dall’inglese. Un’indagine condotta sulle tre antologie più diffuse nel- le scuole italiane rivela un trattamento superficiale e disinvolto dei testi tradotti, che mol- to spesso sono adattati e ridotti, e che nella maggior parte dei casi sono riportati in italia- no senza l’indicazione della lingua di partenza, né del nome del traduttore o della tra- duttrice. È probabile che il ricorso a opere letterarie tradotte dall’inglese per l’insegna- mento dell’italiano non corrisponda a un particolare intento educativo ma altro non sia che un riflesso di quella globalizzazione del mercato editoriale che ha portato a un pre- dominio crescente dell’inglese. Tuttavia, indipendentemente dalle intenzioni di chi pro- duce i libri e di chi li sceglie, occorre indagare le possibili conseguenze del ricorso a questi strumenti dal punto di vista educativo, soprattutto per quel che riguarda lo svilup- po dell’apprezzamento della diversità culturale e dell’interesse e la curiosità per lingue diverse e per la comunicazione interculturale.
Kombinasi Terapi Zikir dan Rendam Air Hangat Terhadap Tekanan Darah pada Lansia Penderita Hipertensi di Wilayah Kerja Puskesmas Pekauman
Authors: Jailani Muhamad , Wijaksono Muhammad Arief
Published: January 2025

Hipertensi adalah penyakit tidak menular yang menjadi penyebab utama kematian dini di seluruh dunia dan merupakan penyakit terbanyak pada usia lanjut di Indonesia, dengan prevalensi 60,3% penderita. Hipertensi perlu mendapatkan penanganan yang komprehensif untuk menurunkan tekanan darah, meliputi terapi konvensional dan terapi non konvensional (komplementer). Rendam air hangat dengan kombinasi terapi zikir dapat menurunkan tekanan darah. Menganalisis pengaruh terapi zikir dengan kombinasi terapi rendam kaki air hangat pada kelompok intervensi. Metode penelitian ini menggunakan Rancangan penelitian ini adalah penelitian kuantitatif dengan jenis penelitian pra-eksperiment menggunakan desain penelitian one group pretest posttest design. Populasi yang diambil adalah lansia hipertensi di wilayah kerja Puskesmas Pekauman yaitu di Di Jln. Mutiara RT. 11, RW. 01. Jumlah sampel pada penelitian ini berjumlah 15 orang yang dipilih berdasarkan teknik total sampling. Uji statistik yang digunakan adalah Wilcoxon Sign Test. Hasil penelitian didapatkan Hasil uji statistik menunjukkan pemberian intervensi terapi zikir dengan kolaborasi rendam air hangat selama 7 hari berpengaruh dalam menurunkan tekanan darah lansia penderita hipertensi dengan nilai p value 0,001 yang artinya intervensi terapi zikir dengan kolaborasi rendam air hangat memberikan pengaruh yang signifikan terhadap penurunan tekanan darah lansia penderita hipertensi.
Manajemen Puskesmas Terhadap Mutu Pelayanan Puskesmas di Kota Padang
Authors: Asyari Dian Paramitha , Azkha Nizwardi
Published: January 2025

Mutu pelayanan merupakan faktor penting yang dapat membentuk kepercayaan pasien kepada Puskesmas sehingga tercipta loyalitas mereka sebagai konsumen jasa pelayanan kesehatan. Tercatat sepanjang tahun 2023 mutu pelayanan Puskesmas di Kota Padang masih bermasalah terutama pada bagian sarana prasarana dan kualitas layanan yang diberikan. Tentunya hal ini dapat teratasi jika pelaksanaan manajemen di Puskesmas juga baik dan terstandar. Penelitian ini bertujuan untuk melihat hubungan antara manajemen puskesmas terhadap mutu pelayanan di  23 puskesmas dengan jumlah sampel 46 orang di Kota Padang. Metode yang digunakan adalah pendekatan Kuantitatif dengan teknik penentuan sampel secara total sampling di 23 Puskesmas Kota Padang. Analisis data menggunakan analisis Bivariate dan uji Korelasi Pearson. Hasil penelitian  menunjukkan adanya hubungan positif yang signifikan antara manajemen Puskesmas dan mutu pelayanan, dengan nilai korelasi Pearson sebesar 0,68 (p < 0,01).
MENGGALI POTENSI BUMDES PULOTONDO DALAM UPAYA MENINGKATKAN EKONOMI MASYARAKAT
Authors: Yusna  , Elvyra Handayani Soedarno  , Retno Widiastuti  , Nurafni Eltivia  , Ima Kristanti  , Berlianingtyas Putri Ayu , Indira Niaqaulina
Published: January 2025

Badan Usaha Milik Desa yang selanjutnya disebut BUMDes merupakan salah satu alternatifuntuk meningkatkan ekonomi di pedesaan. BUMDes lahir sebagai suatu pendekatan baru dalam usahapeningkatan ekonomi desa berdasarkan kebutuhan dan potensi desa. Pengelolaan BUMDessepenuhnya dilaksanakan oleh masyarakat desa, yaitu dari desa, oleh desa, dan untuk desa. Dari hasilanalisis bahwa Desa Pulotondo memiliki banyak potensi yang dapat dikembangkan melalui unit usahaBUMDes diantaranya, budidaya ikan air tawar, penjualan jeruk purut serta olahan jeruk purut yangdijadikan bubuk aroma ataupun menjadi minyak atsiri yang menjadi lilin terapi, mengembangkanusaha catering ibu-ibu PKK, dllBentuk Pengabdian yang direncanakan adalah FGD dengan memberikan contoh-contohbisnis yang potensial dan aplikatif yang dapat dijalankan pada lokasi setempat. Peserta juga akandiberikan kesempatan untuk menyampaikan potensi-potensi pengembangan bisnis lain yang mampudihasilkan. Tim pelaksana PPM juga akan memberikan kesempatan untuk diskusi lebih lanjut padatim pengusul PPM secara informal dan tidak menutup kemungkinan dapat dilakukan kegiatan lanjutanberupa pendampingan di masa mendatang dalam mengawal pengoptimalan BUMDes.Diharapkan dengan adanya kegiatan Pengabdian pada Masyarakat ini dapat memberikanBUMDes ide pengembangkan bisnis dan wirausaha yang dapat dijalankan oleh warga sekitar terutamadalam peningkatan pengolahan dan pemasaran produk perikanan dan pertanian. Selain itu BUMDesdapat menemukan potensi usaha lain seperti wisata atau edukasi bagi masyarakat Jawa Timur.Diharapkan dengan kegiatan ini dapat menjalin kerjasama yang baik hingga pada tahap kerjasamamenjadi desa binaan Politeknik Negeri Malang.
PELATIHAN UMKM DESA REJOSARI MENJADI GO DIGITAL MELALUI DIGITAL MARKETING DAN PENGELOLAAN KEUANGAN DIGITAL
Authors: Rachmaniyah Fatichatur , Ulfah Anisa , Sari Finas Intan , Indah Maulida Alif
Published: January 2025

In the digital era, MSMEs are faced with the challenge of adapting to technology in order to remain competitive. This study aims to improve the competitiveness of Micro, Small, and Medium Enterprises (MSMEs) of herbal drinks in Rejosari Village, Lamongan. This is done through digital marketing and financial management training using the Qasir application. This training includes socialization of the importance of digital marketing and direct practice using social media platforms and financial management applications. The results of the study showed a significant increase in participants' digital knowledge and skills. In addition, participants showed a high interest in applying the knowledge gained in running their businesses. However, there are still several obstacles faced, such as the lack of digital literacy. This study concludes that digital training can be an effective solution to improve the competitiveness of MSMEs in rural areas.
PELATIHAN PENGELOLAAN DAN PEMASARAN PRODUK UMKM SEBAGAI PENDUKUNG USAHA KAWASAN PARIWISATA DI DESA DUWET, KECAMATAN TUMPANG, KABUPATEN MALANG
Authors: Lestari Pritantina Yuni , Kartikasari Prima Beauty , Cahyani Hilda , Safitri Isnaini Nur , Putri Aulia Nourma , Rohani Siti
Published: January 2025

This community service is aimed at accommodating the needs of tourism area business actors in Duwet Village in improving the management and marketing of MSME products through Focused Group Discussion (FGD). Participants in this activity are business actors in the tourism area in Duwet village, Malang. This activity is expected to improve the quality of MSME products in Duwet Village through product management and marketing, which then can be implemented to provide better services to visitors to the Duwet Village tourism area. This activity was carried out in some stages, namely planning (to find out the number of participants who were involved and the materials needed for the training), coordination with the related parties (representative of partner village members, travel agent, and tour guide) to ensure the plans made are in accordance with needs, preparation of Focused Group Discussion (FGD) materials, survey to the exact location in the partner village to ensure the prepared materials are suitable with the condition of the village, doing FGD with the, and evaluation which is giving questionnaires to the participants regarding the implementation and materials.
Individual determinants of extended working lives: A systematic review of the literature
Authors: Gutiérrez Rodolfo , López-Rodríguez Fermín , Tejero Aroa
Published: January 2025

The extension of working lives (EWL) appears as a long-term transforma­tion driven by the increase in longevity and the expansion of institutional incentives to postpone retirement. However, the increase in average re­tirement ages is being less intense and more heterogeneous than prom­ised by pension reforms. The mismatch between structural and individual changes reinforces the interest of a precise knowledge of the influence of individual determinants on EWL. Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology (Page et al. 2021), this article provides a systematic review of literature with the objective of conceptualizing variants of EWL and systematizing empirical evidence of the influence of individual determinants on EWL. This review can be of benefit both for detecting the areas on which future research should focus and for guiding the discussions on potential pension system reforms while considering the heterogeneity of individuals’ profiles.
Fundamentals of bio-based technologies for selective metal recovery from bio-leachates and liquid waste streams
Authors: Sieber Anna , Spiess Sabine , Rassy Wadih Y. , Schild Dominik , Rieß Thomas , Singh Shalini , Jain Rohan , Schönberger Nora , Lederer Franziska , Kremser Klemens , Guebitz Georg M.
Published: January 2025

The number of metal-containing waste streams resulting from electronic end-of life products, metallurgical by-products, and mine tailings to name but a few, is increasing worldwide. In recent decades, the potential to exploit these waste streams as valuable secondary resources to meet the high demand of critical and economically important raw materials has become more prominent. In this review, fundamental principles of bio-based metal recovery technologies are discussed focusing on microbial metabolism-dependent and metabolism-independent mechanisms as sustainable alternatives to conventional chemical metal recovery methods. In contrast to previous reviews which have partially addressed this topic, a special focus will be given on how fundamental principles of bio-based recovery technologies can influence the selectivity and specificity of metal recovery. While conventional methods for metal recovery show benefits in terms of economic affordability, bio-based recovery technologies offer advantages in terms of efficiency and environmentally friendliness. Modifications and adaptations in the processes of biosorption, bioaccumulation and bioelectrochemical systems are highlighted, further emphasizing the application of metal-binding peptides and siderophores to increase selectivity in the recovery of metals. Single metal solutions or mixtures with a low complexity have been the focus of previous studies and reviews, but this does not reflect the nature of complex industrial effluents. Therefore, key challenges that arise when dealing with complex polymetallic solutions are addressed and the focus is set on optimizing bio-based technologies to recover metals efficiently and selectively from bio-leachates or liquid waste streams.
Technology usage and glycaemic outcomes in a single tertiary centre with an ethnically diverse and socioeconomically deprived cohort of children with type 1 diabetes mellitus
Authors: Dickinson India , Gupta Ankita , Lau Gar Mun , Iyer Pranav Viswanath , Pemberton John Stuart , Uday Suma
Published: January 2025

Background

The UK National Paediatric Diabetes Audit (NPDA) data reports disparities in Haemoglobin A1c (HbA1c) levels among children and young people (CYP) with Type 1 Diabetes (T1D), with higher levels in those of Black ethnic background and lower socioeconomic status who have less access to technology. We investigate HbA1c differences in a T1D cohort with higher than national average technology uptake where > 60% come from an ethnic minority and/or socioeconomically deprived population.

Design & methods

Retrospective cross-sectional study investigating the influence of demographic factors, technology use, and socioeconomic status (SES) on glycaemic outcomes. The study population was 222 CYP with T1D who attended the diabetes clinic in 2022 at a single tertiary paediatric diabetes centre.

Results

Among 222 CYP, 60% were of ethnic minority (Asian, Black, Mixed and Other were 32%, 12%, 6% and 10% respectively) and 40% of white heritage. 94% used Continuous Glucose Monitoring (CGM) and 60% used Continuous Subcutaneous Insulin Infusion (CSII) via open or closed loop. 6% used Self-Monitoring of Blood Glucose (SMBG) and Multiple Daily Injections (MDI), 34% used CGM and MDI, 38% used CGM and CSII and 22% used Hybrid Closed-Loop (HCL) systems. Significant differences in HbA1c across therapy groups (p < 0.001) was noted with lowest HbA1c in HCL group (55 mmol/mol; p <0.001). Despite adjusting for therapy type, the Black group had higher HbA1c than their white and Asian counterparts (p<0.001). CYP from the most deprived tertile had significantly higher HbA1c levels (p < 0.001) but the difference was not sustained after adjusting for therapy type.

Conclusion

Advanced diabetes technologies improve glycaemic control. Whilst equalising technology access mitigates socioeconomic disparities in HbA1c, CYP from Black ethnic background continue to display a higher HbA1c. The study underscores the necessity of fair technology distribution and further research into elevated HbA1c levels among Black CYP using advanced diabetes technology.
Evolution of de Winter syndrome to Wellens syndrome: a case report and literature review
Authors: Wang Fei , Zhang Xuesong , Pang Huihui , Wang Yuehai
Published: January 2025

Both de Winter syndrome and Wellens syndrome mainly indicate severe stenosis in the proximal segment of the anterior descending coronary artery. However, as research deepens, the accuracy and specificity of diagnosing proximal left anterior descending coronary artery (LAD) culprit lesions separately by de Winter syndrome or Wellens syndrome are challenged. The patient in this case developed both syndromes in a short period of time, and imaging showed significant stenosis of the proximal LAD, indicating a culprit lesion. The successive appearance of these two special electrocardiogram changes may increase the accuracy and specificity of diagnosing LAD as a culprit lesion, and the short-term occurrence of these two special electrocardiogram changes also suggests that the culprit lesion may be incomplete occlusion. In addition, de Winter syndrome is prone to missed diagnosis, while Wellens syndrome is prone to misdiagnosis or underestimation of its risk.
The type of exercise most beneficial for quality of life in people with atrial fibrillation: a network meta-analysis
Authors: Yang Zhen , Qi Xiaoting , Li Gaopeng , Wu Na , Qi Bingwen , Yuan Mengyang , Wang Yaxin , Hu Guangling , Yang Qiaofang
Published: January 2025

Introduction

Atrial fibrillation (AF) significantly detracts from health-related quality of life (HRQoL). Despite the promotion of exercise interventions for managing AF, the effectiveness of different exercise modalities remains to be clearly defined. This systematic review and network meta-analysis aims to evaluate the comparative effectiveness of various modes of exercise interventions on HRQoL in AF patients.

Methods

A random-effect network meta-analysis was performed. We conducted comprehensive searches across multiple databases, including PubMed, Web of Science, Embase, Cochrane Library, Scopus, and Chinese databases such as CNKI, WanFang Data, and VIP. The review included only randomized controlled trials (RCTs) that investigated the effects of exercise interventions on HRQoL among individuals diagnosed with AF.

Results

The network meta-analysis (NMA) incorporated 12 studies, of which five presented some concerns regarding risk of bias and one exhibited a high risk of bias. For total HRQoL in AF patients, aerobic exercise, and cardiac rehabilitation (CR) yielded standardised mean differences of 0.60 (95% CI: 0.02–1.13) and 0.59 (95% CI: 0.20–0.99), respectively. For the physical component of HRQoL, CR was most efficacious, demonstrating the highest Surface Under the Cumulative RAnking curve (SUCRA) value of 77%. For the mental component of HRQoL, high-intensity interval training (HIIT) was superior, with the highest SUCRA value of 90.7%.

Conclusions

Both aerobic exercise and CR effectively improve the physical and mental dimensions of HRQoL as well as overall HRQoL in patients with AF. However, for the mental component of HRQoL, HIIT was identified as the most effective intervention.
Association between triglyceride-glucose index and endometriosis: results from a cross-sectional study and Mendelian randomization study
Authors: Xu Ting , Zhuang Yuan , Cao Huabin , Yang Jingqi
Published: January 2025

Background

Triglyceride-glucose (TyG) index has been found to be associated with female reproductive disorders, but its relationship with the risk of endometriosis is unknown. Therefore, the aim of this study was to investigate this relationship.

Methods

We performed a two-sample mendelian randomization(MR) analysis to examine the causal effect of TyG index on endometriosis, and inverse variance weighting(IVW) was the main method of analysis. Then, we selected 1484 participants with endometriosis from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2006. Weighted multivariable-adjusted logistic regression and smoothed curve analysis were used to evaluate the correlation between the TyG index and endometriosis.

Results

The results of MR analysis confirmed that higher TyG index was causally associated with the risk of endometriosis (OR=1.27, 95%CI: 1.05-1.54, P=0.01). In the cross-sectional study, subjects in the highest quartile of TyG index had the highest risk of incident endometriosis after adjusting for covariates(OR = 2.41, 95% CI:1.31-4.44, P for trend <0.01). The smoothed curve analysis also revealed a positive linear correlation between TyG index and endometriosis.

Conclusion

Our study confirms that a higher TyG index is associated with an increased risk of endometriosis by MR analysis and cross-sectional study. These findings suggested that TyG index could serve as a biomarker in identifying individuals who may be at a higher risk for developing endometriosis. Further research is needed to explore the potential clinical implications of these findings and to elucidate the underlying mechanisms behind this observed relationship.
Extracellular vesicular microRNAs and cardiac hypertrophy
Authors: Hu Hai , Wang Xiulian , Yu Hui , Wang Zhanli
Published: January 2025

Cardiac hypertrophy is an adaptive response to pressure or volume overload such as hypertension and ischemic heart diseases. Sustained cardiac hypertrophy eventually leads to heart failure. The pathophysiological alterations of hypertrophy are complex, involving both cellular and molecular systems. Understanding the molecular events that inhibit or repress cardiac hypertrophy may help identify novel therapeutic strategies. Increasing evidence has indicated that extracellular vesicle (EV)-derived microRNAs (miRNAs) play a significant role in the development and progression of cardiac hypertrophy. In this review, we briefly review recent advancements in EV research, especially on biogenesis, cargoes and its role in cardiac hypertrophy. We then describe the latest findings regarding EV-derived miRNAs, highlighting their functions and regulatory mechanisms in cardiac hypertrophy. Finally, the potential role of EV-derived miRNAs as targets in the diagnosis and treatment of cardiac hypertrophy will be discussed.
Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease
Authors: Fan Yu-Hong , Zhang Siyao , Wang Ye , Wang Hongni , Li Hongliang , Bai Lan
Published: January 2025

Non-alcoholic fatty liver disease (NAFLD) is a multisystem metabolic disorder, marked by abnormal lipid accumulation and intricate inter-organ interactions, which contribute to systemic metabolic imbalances. NAFLD may progress through several stages, including simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis, and potentially liver cancer. This disease is closely associated with metabolic disorders driven by overnutrition, with key pathological processes including lipid dysregulation, impaired lipid autophagy, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and local inflammation. While hepatic lipid metabolism in NAFLD is well-documented, further research into inter-organ communication mechanisms is crucial for a deeper understanding of NAFLD progression. This review delves into intrahepatic networks and tissue-specific signaling mediators involved in NAFLD pathogenesis, emphasizing their impact on distal organs.
Evaluation and improvement of power quality of distribution network: a case study of Covenant University, Ota
Authors: Samuel Isaac A. , Toyin Daudu Afah , Somefun Tobiloba E. , Awelewa Ayokunle A. , Abba-Aliyu Shehu
Published: January 2025

Power quality is a global concern, particularly as electronic devices are increasingly supporting modern economies. This research evaluates and proposes improvements for power quality of the distribution network at Covenant University, Ota, Nigeria, where electrical equipment usage contributes to power quality challenges. Measurements and evaluations were carried out in three stages: first, measuring power quality at five campus powerhouses using a Circutor aR6 power analyzer; second, assessing these measurements with Power Vision software; third, simulating the evaluated network with NEPLAN software. The study was conducted during an active school session, with measurements taken at 500 kVA, 11 kV/415 V/230 V on the outgoing circuits for each transformer. The results were benchmarked against IEEE power quality standards and identified issues such as harmonics, total harmonic distortion (THD), overload, and a lagging power factor. The proposed improvements, derived from NEPLAN simulation, included active harmonic filters to reduce harmonics, a shunt capacitor for power factor correction, and load sharing for managing transformer overloads. Simulation results demonstrated that THD was significantly reduced across all powerhouses: CDS from 7.28% to 0.91%, EIE from 10.52% to 3.54%, CST from 16.03% to 0.58%, the Library from 11.92% to 0.12%, and the Male Hostel from 16.71% to 0.24%. These adjustments enhanced THD within specified limits. Additionally, the shunt capacitor increased the power factor to 0.96 from −0.96. These enhancements are expected to extend equipment life, reduce heat loss, and lower utility costs.
Impact of multi-scenario land-use changes on habitat quality evolution in the Yangtze River economic belt
Authors: Dong Bowen , Huang Tiantian , Tang Tao , Huang Delin , Tang Chen
Published: January 2025

Ecosystems worldwide are facing significant challenges resulting from the dual pressures of global climate change and human activities, particularly in terms of significant biodiversity loss associated with land-use change. Focusing on the Yangtze River Economic Belt (YREB), this study uses the System Dynamics (SD) - Patch-generating Land Use Simulation (PLUS) model to simulate land-use development under different scenarios of shared socio-economic pathways (SSPs) and representative concentration pathways (RCPs) from 2030 to 2050. Furthermore, the InVEST model is applied to evaluate changes in habitat quality (HQ) over the period 2000 to 2050. A hotspot analysis further highlights the spatial heterogeneity of HQ within the YREB. The study showed that the land-use pattern in the YREB from 2020 to 2050 will be dominated by cropland in the eastern region, grassland in the north-west, and forest land in the central and southern regions, with a steady increase in built-up land in the east. The HQ index exhibits a gradual increase from east to west, ultimately declining to 0.726 under the SSP585 scenario for 2050. This trend reflects moderate habitat degradation (HD), with the degree of degradation shifting towards lower and higher proportions of HQ. Spatial analysis of HQ further reveals that the eastern region is identified as a cold spot, the central region is categorized as non-significant, while the western region emerges as a hot spot, where HQ exceeds 40%. These findings offer a scientific foundation for promoting high-quality development and enhancing biodiversity conservation in the YREB.
Adsorption and removal of pentavalent antimony from water by biochar prepared from modified rosa roxburghii residue
Authors: Dai Yong , Zhao Shengmao , Zheng Ruyi
Published: January 2025

In order to investigate the adsorption properties of modified rosa roxburghii residue biochar to antimony (Sb) in water, the modified rosa roxburghii residue biochar (BC-FeOOH) was prepared from rosa roxburghii residue factory in Guizhou Processing plant. The adsorption characteristics of BC-FeOOH on Sb(V) in water were investigated by batch test experiments with different pH, biochar dosage and adsorption time. The results showed that the best adsorption effect of BC-FeOOH on antimony was achieved at the dosage of 0.05 g and pH 2.0, and the adsorption amount reached 5.7 mg/g. The results of adsorption kinetic modeling showed that the equilibrium time of the adsorption of BC-FeOOH on Sb(V) in water was in the range of 8–10 h, and the mechanism of adsorption was mainly chemical adsorption. Langmuir model can better describe the adsorption process of BC-FeOOH on Sb(V), and the surface adsorption process is monomolecular layer chemisorption. The experimental results showed that BC-FeOOH is a good adsorbent for Sb pollution remediation in water. This study provides n ew insights for the development of Sb contamination removal strategies in water and offers a new way for the resource utilization of prickly pear pomace.