bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on the characteristics of highly-cited papers on pandemics from the perspective of alternative metrology
Authors: Zou Zongfeng , Sun Xi-yun , Nan Lv , Shao Wei , Wu Jingwen
Published: August 2024

[Background] At present, an increasing number of researchers have studied pandemics and published papers to help people better cope with pandemics.
[Purpose/significance] This study explores the value of Altmetrics to facilitate academic responses to pandemics on the web and helps public health organizations design communication strategies through an analysis of the dissemination characteristics of high-cited pandemic papers on social media. To excavate the potential of pandemic papers from the perspective of alternative measurement is also beneficial to more objectively and effectively evaluate the social influence of those papers.
[Method/process] Correlation analysis was carried out between traditional bibliometric indicators and various Altmetrics indicators. We can also more clearly understand the characteristics of academic dissemination on Twitter and Mendeley platforms by using visual analysis and descriptive statistical analysis methods.
[Result/Conclusion] Our findings conclude that online media has become an important tool for disseminating scientific knowledge related to global pandemics. The Altmetric indicators are significantly different from the citation indicator, which can express the impact of the high-cited pandemic papers from a new perspective.In conclusion, Altmetrics will be a perfect supplement to the quantitative evaluation of such papers.
Revealing the biodiversity of wild bees (Hymenoptera: Apoidea: Anthophila) in flower strips in Mediterranean floodplains. Which monitoring method fits best?
Authors: Moldoveanu Oana Catalina , Maggioni Martino , Vergari Daniele , Dani Francesca Romana
Published: August 2024

Context
The ongoing pollinator decline may threaten and compromise the resilience of terrestrial ecosystems. Implementing conservation action requires monitoring pollinator populations' actual status, but this is particularly difficult for pronubes insects such as wild bees. Their monitoring is difficult and time-consuming but crucial for assessing their health status.
Objectives
Here we compared and evaluated the efficiency of three different monitoring methods to evaluate wild bee biodiversity in lowland areas sown with entomophilous flowers to support pollinating insects in a Mediterranean environment.
Methods
We sampled wild bees for two years by using hand netting, pan traps and artificial nests. We compared species richness and abundance among these methods with a particular focus on how flowering coverage affects the efficiency of walking transects and pan traps and discussed the attractiveness of the different colours of pan traps.
Results
Hand netting captured a higher abundance of wild bees than the other two methods but a similar number of species to pan traps. Artificial nests captured fewer specimens and species. Bee assemblages were significantly different between pan traps and hand netting, and pan traps had greater potential in capturing the whole bee biodiversity, but their attractiveness is negatively influenced by the flowering coverage contrary to hand netting sampling.
Conclusions
Like other studies, the three sampling methods are complementary regarding species assemblages. The juxtaposition of several monitoring methods is essential to assess the biodiversity status of species with such particularly different ecological traits.
IoT and Machine Learning Based Techniques for Monitoring and Predicting Water Hyacinth Expansion Rate in Lake Tana Ecosystem
Authors: Amssaya Haileyesus , Mekuria Fisseha , Tegegne Tesfa
Published: August 2024

This paper presents smart IoT networks and machine learning algorithm to monitor the aquatic environment. The growth and expansion of invasive plants in freshwater lakes requires an accurate monitoring and long-term data collection tool, which the system proposed in this paper is addressing. The expansion of invasive weed water hyacinth highly affects the biodiversity and environment of freshwater lakes and rivers. Dynamic and continuous environmental monitoring system increases the prediction accuracy of machine learning algorithms by delivering real time data. Predicting the seasonal and daily water hyacinth weed expansion rate intensity of lake Tana improves the biodiversity of the lake and living standards of the community. Laboratory based experimental data is used to predict the relationship between the intensity of water hyacinth expansion rate and influencing environmental features such as depth, temperature, pH, total nitrogen, total phosphorous and chlorophyl-a contents of lake Tana. Four machine learning techniques namely multivariate linear regression, random forest, support vector machine and extreme gradient boosting algorithms are applied for data analysis. The random forest machine learning algorithm predicts water hyacinth annual expansion rate intensity better than others.
Long-term commitment critical to reach forest restoration’s climate mitigation potential in East Africa
Authors: Liang Mengyu , Minor David , Silva Julie , Fatoyinbo Lola , Thomas Nathan , Goor Wouter van , Riemer Kars , Kigenyi Richard , Cohen Rachel , Negussie Aklilu , Jin Chen , Healey Sean , Cook-Patton Susan , Costedoat Sébastien , Heilmayr Robert , Chazdon Robin , Hansen Matthew , Dubayah Ralph , Urbazaev Mikhail , Durrant Eleanor , de Haas Sander , Duncanson Laura
Published: August 2024

Forest restoration is gaining momentum as a natural climate solution to provide carbon dioxide removal while also addressing the biodiversity crisis. Globally, three primary restoration strategies—natural regeneration, assisted natural regeneration, and active restoration—have been adopted. However, inconsistent monitoring of forest dynamics mean large uncertainties remain over their long-term potential to enhance carbon (C) removal. We examined over 30 years of forest aboveground carbon (AGC) estimates from high-resolution lidar, Landsat imagery, and field data across East Africa. Our study shows that assisted natural regeneration and active restoration outperform natural regeneration in enhancing forest C removal capacity, with long-term implementation (over 9 years) needed to overcome the initial lags in AGC accumulation. Restoring 14.24 million hectares of suitable areas available in East Africa, representing 2.1% of suitable restoration areas globally, could enhance forest C removal by 2.85 ± 0.82 gigatons of C (Gt C) by 2050. However, less than one quarter of this potential would be achieved by 2030. This research advances our understanding of forest restoration’s potential for enhancing C removal and the time scale for meeting climate targets. We demonstrate that long-term commitments in implementation and investment are critical for restoring forests effectively for climate mitigation.
The Role of Weather Forecasts in Climate Adaptation and Reducing Medical Costs in China
Authors: Cong Zhenglong , Liu Qingfeng , Ni Chenxu
Published: August 2024

Exploring cost-effective climate adaptation strategies is crucial for human well-being, yet little is known about whether and how information interventions promote climate adaptation. This paper provides the first analysis of the role of weather forecasts in reducing the health impacts of climate change, utilizing large-scale, fine-grained medical expenditure data from China’s largest medical insurance program. Our analysis reveals accurate forecasts significantly reduce weather-related medical cost: a one-degree Celsius deviation from the accurate forecast increases medical expenses over the next seven days by 13.7% when underestimating and 4.6% when overestimating the realized temperature.Moreover, the potential value of improving forecast accuracy will escalate with ongoing global warming, as the negative impacts of inaccurate forecasts are especially severe under extreme weather conditions. Out findings highlight the substantial potential of information interventions for climate adaptation and enhance understanding of health-related impacts of climate change.
Video-to-Text Pedestrian Monitoring (VTPM): Leveraging Computer Vision and Large Language Models for Privacy-Preserve Pedestrian Activity Monitoring at Intersections
Authors: Abdelrahman Ahmed S. , Abdel-Aty Mohamed , Wang Dongdong
Published: August 2024

Computer vision has advanced research methodologies, enhancing system services across various fields. It is a core component in traffic monitoring systems for improving road safety; however, these monitoring systems don’t preserve the privacy of pedestrians who appear in the videos, potentially revealing their identities. Addressing this issue, our paper introduces Video-to-Text Pedestrian Monitoring (VTPM), which monitors pedestrian movements at intersections and generates real-time textual reports, including traffic signal and weather information. VTPM uses computer vision models for pedestrian detection and tracking, achieving a latency of 0.05 seconds per video frame. Additionally, it detects crossing violations with 90.2% accuracy by incorporating traffic signal data. The proposed framework is equipped with Phi-3 mini-4k to generate real-time textual reports of pedestrian activity while stating safety concerns like crossing violations, conflicts, and the impact of weather on their behavior with latency of 0.33 seconds. To enhance comprehensive analysis of the generated textual reports, Phi-3 medium is fine-tuned for historical analysis of these generated textual reports. This fine-tuning enables more reliable analysis about the pedestrian safety at intersections, effectively detecting patterns and safety critical events. The proposed VTPM offers a more efficient alternative to video footage by using textual reports reducing memory usage, saving up to 253 million percent, eliminating privacy issues, and enabling comprehensive interactive historical analysis.
WITHDRAWN: Macroeconomic Factors Underlying External Currency Instability in Developing Countries: Analysis of the Democratic Republic of Congo (DRC) from 1990 to 2022.
Authors: FATAKI ALEXANDRE DONATIEN
Published: August 2024

This Article aims to investigate the intricate web of macroeconomic factors contributing to external currency instability in developing countries, with a particular focus on the Democratic Republic of Congo (DRC) from 1990 to 2022. Employing the Econometric modeling framework, this research offers a unique perspective by analyzing traditional macroeconomic variables and additional dimensions can be taken into account in order to set up a comprehensive analytical framework. The study seeks to unveil the complex interplay of these factors and their collective impact on the external stability of the currency in the selected timeframe.
A Positive Feedback-Based Body-Driven Transconductance Amplifier
Authors: Akbari Meysam
Published: August 2024

In this paper, an ultralow-power ultralow-voltage CMOS operational transconductance amplifier (OTA) with a rail-to-rail input/output swing is presented. The proposed two-stage OTA is designed based on a body-driven current mirror (CM) amplifier with a Gm-C frequency compensation technique. In addition, a transconductance boosting technique is used to enhance the performance of the input stage structure without adversely affecting the noise performance. Simulation results for 0.18 µm CMOS technology show that the proposed OTA achieves an 86 dB DC gain and a gain bandwidth of 21.9 kHz while driving a 15 pF load. The amplifier consumes 292 nW @ 0.5 V, which makes it suitable for ultralow-power applications.
Comorbidities and Monitoring in Patients with Chronic Hepatitis B on Nucleos(t)ide Analogues Attending a Tertiary Hospital in Malaysia, Southeast Asia: A Critical Perspective
Authors:   Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Bello Kizito Eneye ,   Kogi State University (Prince Abubakar Audu University) Anyigba, Kogi State, Nigeria, Kelechi Itodo Janefrancis ,   Kogi State University (Prince Abubakar Audu University) Anyigba, Kogi State, Nigeria, David Zakari A. ,   Kogi State University (Prince Abubakar Audu University) Anyigba, Kogi State, Nigeria, Omebije Adejo Patience ,   Kogi State University (Prince Abubakar Audu University) Anyigba, Kogi State, Nigeria, Shueb Rafidah Hanim ,   Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia,   Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Kelantan, Malaysia, Mustaffa Nazri ,   Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia,   Hospital Universiti Sains Malaysia, Kelantan, Malaysia
Published: August 2024

Background: Chronic hepatitis B (CHB) is a significant global public health concern in Malaysia. It is a potentially life-threatening liver disease caused by the hepatitis B virus (HBV), which can lead to long-term complications such as cirrhosis, liver failure and hepatocellular carcinoma. In managing CHB, nucleos(t)ide analogues (NAs) have become the preferred treatment due to their ability to suppress viral replication and prevent disease progression. The question of liver-associated comorbidities related to patients with CHB on NAs remains unresolved in Malaysia despite the impending burden of CHB in the country. This study intends to address this and related aspects. Method: We assessed 136 CHB patients on NAs in one centre, the Hospital Universiti Sains Malaysia. Demographic and epidemiological data on the treatment, concomitant disease and monitoring strategies were collected and analysed. Result: Patients on NAs aged 50 years old–70 years old had the highest proportion of CHB (45.59%), with males representing 61.03% of that age group. There was a statistical significance in CHB acquisition and presence of comorbidities at P > 0.005. Our cohort displayed seven comorbidities (diabetes, obesity, rheumatoid diseases, renal impairment, spontaneous bacterial peritonitis, hypertension, non-hepatocellular malignancies and carcinoma); hypertension had the highest incidence (69.12%), while renal impairment had the lowest incidence (8.09%). Whole blood count, liver function and creatinine tests were the major monitoring tests used in over 90% of the cohort compared to viral load (6.1%). Conclusion: Diabetes, hypertension and obesity were independent risk factors for acquiring liver cirrhosis and hepatocellular carcinoma. Malaysian CHB patients treated with NAs have several comorbidities that could affect disease outcomes. Therefore, careful monitoring is required.
The Association between Drug-Related Problems and Length of Stay of Type 2 Diabetes Mellitus Patients
Authors:   Doctoral Program in Pharmacy, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia, Larasati Niken ,   Pharmacy Study Program, Faculty of Health, Jenderal Achmad Yani University, Yogyakarta, Indonesia, Satibi Satibi ,   Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia, Kristina Susi Ari ,   Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia, Lazuardi Lutfan ,   Department of Public Health, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia
Published: August 2024

Introduction: Drug-related problems (DRPs) are treatment-related occurrences that affect therapeutic efficacy. In a previous study, approximately 279 out of 330 (84.5%) patients with type 2 diabetes mellitus (T2DM) had experienced at least one DRP, including non-optimal drug effects (n = 240, 52.7%) and indications without medication (n = 137, 30.1%). Patients who were hospitalised for 5–10 days had the highest number of DRPs. Therefore, this study investigates the association between DRPs and length of stay (LoS) in patients with T2DM. Methods: A cross-sectional study was conducted from January 2020 to May 2023 at Rumah Sakit Akademik, Universitas Gadjah Mada, Yogyakarta, Indonesia. Clinical pharmacists reviewed electronic health data to examine DRPs. The Fisher’s exact test evaluated the association between DRPs and LoS. Results: A total of 60.7% (n = 17) of the participants were females, with the majority falling into the age group ≥ 65 years old (n = 11, 29.7%). A significant portion experienced LoS > 7 days (n = 17, 60.7%). Antidiabetic monotherapy was predominant, and the categories of DRPs included adverse drug reaction (n = 15, 40.5%), dosage too high (n = 6, 16.2%), wrong drug (n = 6, 16.2%), non-adherence (n = 4, 10.8%), need for additional therapy (n = 4, 10.8%) and dosage too low (n = 2, 5.4%). A significant association was observed between non-adherence and LoS (P = 0.016). The possibility of experiencing LoS of 1–7 days increased by 3.43 times with improved non-adherence (OR = 3.43; 95% CI: 1.83, 6.39). In this context, non-adherence refers to DRPs associated with the non-compliance of patients with the prescribed treatment plan. Conclusion: This study concludes that non-adherence was significantly associated with hospital LoS.
Physiological Profiles of Male Adolescents in Kelantan, Malaysia Practicing Taekwondo and Wushu
Authors:   Exercise and Sports Science Programme, School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Adanan Nur Fadhilah Ain , Ooi Foong Kiew ,   Exercise and Sports Science Programme, School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Samsudin Norsuriani ,   Exercise and Sports Science Programme, School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia,   Faculty of Hospitality, Tourism and Wellness, Universiti Malaysia Kelantan, Kelantan, Malaysia
Published: August 2024

Background: Martial arts training is beneficial for improving physical fitness but the improvements can vary according to the type of martial art performed. This study investigated lung function, aerobic and anaerobic capacity, flexibility, muscular strength and power among male adolescents who were sedentary or who practiced taekwondo or wushu. Methods: A total of 30 male adolescents living in the Kelantan state in Malaysia who were between 14 years old and 20 years old were enrolled and divided into three groups: i) sedentary (control), ii) taekwondo and iii) wushu. Each participant underwent a lung function test, 20 m shuttle run, Wingate anaerobic test and a Sit and Reach test, as well as tests of standing long jump power, handgrip, back and leg strength. Results: Relative to the sedentary control group, the wushu group had significantly higher values than the sedentary control group for fat free mass (P = 0.047), explosive leg power (P < 0.001), aerobic capacity (P < 0.001), forced expiratory volume in 1 s (FEV1) (P = 0.021) and Wingate anaerobic capacity (P < 0.05). The taekwondo group also showed significantly greater values than the sedentary control group for explosive leg power (P = 0.018), forced vital capacity (FVC) (P = 0.014) and FEV1 (P < 0.001). The wushu group exhibited significantly higher explosive leg power (P = 0.010) and Wingate anaerobic capacity parameters including mean power (P = 0.001), anaerobic capacity (P < 0.001) and anaerobic power (P = 0.002) than the taekwondo group. Conclusion: Engagement of male adolescents in wushu and taekwondo was associated with improved physiological profiles compared to those who were in the sedentary control group. Practice of wushu could result in greater explosive leg power and anaerobic capacities than taekwondo.
Effectiveness of the Stroke e-Learning Module on Malaysian Doctors’ Knowledge of Acute Ischaemic Stroke Management
Authors:   Clinical Research Centre, Hospital Seberang Jaya, Seberang Jaya, Pulau Pinang, Malaysia, Albart Stephenie Ann , Yusof Khan Abdul Hanif Khan ,   Department of Neurology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Abdul Rashid Aneesa ,   Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Wan Zaidi Wan Asyraf ,   Department of Medicine, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia, Looi Irene ,   Clinical Research Centre, Hospital Seberang Jaya, Seberang Jaya, Pulau Pinang, Malaysia,   Department of Medicine, Hospital Seberang Jaya, Pulau Pinang, Malaysia, Fan Kee Hoo ,   Department of Neurology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
Published: August 2024

Background: The Stroke e-Learning Module (SEM) is a nationwide initiative to improve stroke care in Malaysia. This study aimed to assess the module’s effectiveness in improving knowledge on acute ischaemic stroke (AIS) management among Malaysian doctors. Methods: This was a pre-post study design. Medical officers, specialists and general practitioners from various disciplines who work in healthcare facilities in Malaysia were recruited virtually from those who registered for the SEM on the Docquity platform between 1 February 2021 and 31 January 2022. The Acute Stroke Management Questionnaire (ASMaQ), an existing validated questionnaire, was used to measure the doctors’ knowledge of AIS management before and after the SEM. The ASMaQ had three domains: i) general stroke knowledge (GSK), ii) hyperacute stroke management (HSM) and iii) advanced stroke management (ASM). The paired t- and the McNemartests were used to evaluate the effectiveness of the module. Results: One hundred and seventy-one participants voluntarily responded to the pre- and post-module questionnaires. The paired t-test revealed statistically significant improvement for the ASM knowledge scores (mean difference = 2.5; 95% CI: 1.8, 3.2; P < 0.001). The baseline proportion of participants with good knowledge of GSK, HSM and ASM were 92.4%, 64.9%, and 76%, respectively. The McNemar test showed that approximately 14% of the participants had significant improvement in ASM knowledge (P < 0.001). However, no significant changes were noted for GSK (–0.6%) and HSM (4.1%). Conclusion: The SEM has been shown to increase Malaysian doctors’ knowledge on ASM. However, greater effort should be made to improve GSK and HSM knowledge, particularly in areas related to stroke thrombolysis.
Unveiling the Potential of ProstateSpecific Membrane Antigen for Precision Diagnosis and Therapy of Prostate Cancer: A Radiopharmaceutical Perspective
Authors:   Centre for Diagnostic Nuclear Imaging, Universiti Putra Malaysia, Selangor, Malaysia, Hassan Hishar , Othman Muhamad Faiz ,   Department of Pharmacy Practice, Faculty of Pharmacy, Universiti Teknologi MARA, Selangor, Malaysia, Ashhar Zarif Naim ,   Department of Nuclear Medicine, Sabah Women and Children Hospital, Sabah, Malaysia, Abdul Razak Hairil Rashmizal ,   Medical Imaging Program, Department of Health and Care Professions, Faculty of Health and Life Sciences, University of Exeter, Devon, United Kingdom, Ahmad Saad Fathinul Fikri ,   Centre for Diagnostic Nuclear Imaging, Universiti Putra Malaysia, Selangor, Malaysia
Published: August 2024

Prostate-specific membrane antigen (PSMA) has proven to be an important target for diagnostic imaging in prostate cancer. As PSMA is overexpressed on the surface of prostate cancer cells, numerous targeted PSMA ligands have been developed. The emergence of PSMA targeting based on small molecules, such as the PSMA-11 ligand (or PSMA-HBED-CC), has led to breakthroughs, such as [68Ga]Ga-PSMA-11, for positron emission tomography (PET) imaging of biochemically recurrent or metastatic castration-resistant prostate cancer (mCRPC). In addition, the recent approval of [177Lu]Lu-PSMA-617 for the treatment of adult patients with PSMA-positive mCRPC represents an important milestone in prostate cancer therapy. These advances underscore the growing confidence in the use of PSMA-targeted radiopharmaceuticals for the diagnosis and treatment of prostate cancer patients. PSMA-targeted radiopharmaceuticals have been shown to significantly impact treatment planning and clinical decision-making and facilitate the customisation of treatment regimens.
Ameliorative Effects of Thymoquinone against Chemotherapy-Induced Testicular Damage in Experimental Animals: A Systematic Review
Authors:   Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Tarmookh Sukinah A. , El-Sheikh Amal Ahmed ,   Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Motawei Kamaluddin H. ,   Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Al-Khater Khulood Mohammed ,   Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Banglore Sujatha ,   Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Aldahhan Rashid A. ,   Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
Published: August 2024

Chemotherapeutic drugs have demonstrated effectiveness in treating various neoplastic conditions; however, they can also have detrimental effects on male gonadal function and fertility. Consequently, interest has grown in identifying novel approaches that can mitigate chemotherapyinduced testicular damage. Thymoquinone (TQ), the chief active component of the volatile oil of Nigella sativa (NS), has a wide range of therapeutic properties, including antioxidant, anti-inflammatory and anti-apoptotic effects. The aim of this systematic review was to identify experimental animal studies that have evaluated the protective effects of TQ against testicular complications associated with chemotherapy. In accordance with the preferred reporting items for systematic review and meta-analyses (PRISMA) guidelines, a thorough search was performed across several databases (PubMed, EBSCOhost, Sage and Scopus) to identify experimental studies published from 2010 to May 2022 that focused on rodent models and compared the effects of TQ versus other chemotherapeutic drugs. Eight studies met the inclusion criteria, comparing TQ with methotrexate (MTX), 6-mercaptopurine (6-MP), cyclophosphamide (CPA), bleomycin (BL), doxorubicin (DOX) or busulfan (BUS). The results of these studies consistently demonstrated that TQ significantly improved sperm parameters, the levels of oxidative stress (OS) markers, apoptosis markers, and hormones and testicular histopathology, indicating that TQ has protective effects against chemotherapy-induced damage. TQ mitigated chemotherapy-induced testicular toxicity by decreasing lipid peroxidation and enhancing the activity of antioxidant enzymes within chemotherapy-treated testes. These findings highlight the potential of TQ as a therapeutic agent that can ameliorate testicular complications associated with chemotherapy, thereby providing a basis for further research and potential therapeutic applications.
Cord Blood 25-Hydroxyvitamin D Level is Correlated with a Risk for Atopic Dermatitis: Systematic Review and Meta-Analysis
Authors:   Department of Dermatology and Venereology, Faculty of Medicine, University of Mataram, Indonesia, Hidajat Dedianto , Haq Abiyyu Didar ,   Medical Doctor Profession Program, Faculty of Medicine, University of Mataram, Indonesia, Warnaini Cut ,   Department of Public Health, Faculty of Medicine, University of Mataram, Indonesia, Kadriyan Hamsu ,   Department of Otolaryngology, Head and Neck Surgery Faculty of Medicine University of Mataram, Indonesia
Published: August 2024

Although Indonesia is located in an equatorial region with adequate year-round sun exposure, the prevalence of 25-hydroxyvitamin D (25[OH]D) deficiency is as high as 90%. Mothers are especially vulnerable to deficiencies due to changes in their gastrointestinal system. Previous studies have reported a correlation between the 25[OH]D status of mothers with atopic dermatitis (AD) and their offspring. However, studies investigating maternal cord blood 25[OH]D levels and the incidence of AD have yielded controversial results due to its variability. As such, this systematic review and meta-analysis aimed to evaluate the correlation between maternal cord blood 25[OH]D levels and the risk for AD. In accordance with Preferred Reporting System for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the PubMed, Cochrane Library and ScienceDirect databases were searched for relevant observational studies and a meta-analysis was performed to obtain odds ratios (OR) and corresponding 95% confidence intervals (CI). Nine studies were included in the qualitative synthesis, five of which were included in the quantitative synthesis. Meta-analysis revealed that cord blood 25[OH]D levels < 50 nmol/L were associated with a 60% higher risk for the development of AD (OR = 1.60; 95% CI: 1.15, 2.22; I2 = 0%; P < 0.05). However, qualitative synthesis revealed a variety of cord blood 25[OH]D measurements and different methods of diagnosing AD in each study. Based on the current analysis, maternal cord blood 25[OH]D levels were significantly correlated with the risk for AD. Therefore, studies investigating 25[OH]D supplementation in pregnant women and its efficacy in decreasing the risk for AD are needed, especially in tropical and equatorial countries. This study also serves as a proof of concept that cord blood 25[OH]D levels can be used as a more affordable predictive parameter for AD.
Upregulation of Serum miR-132 and miR-152 in Vietnamese Patients with Heart Failure
Authors:   Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam, Vu Diem My , Huynh Anh Phuong ,   Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam, Nguyen Nhu Nhat Quynh ,   Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam, Vo Niem Van Thanh ,   Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam, Luong An Bac ,   Cardiovascular Center, University Medical Center, Ho Chi Minh City, Vietnam, Nguyen Thanh Cong ,   Cardiovascular Center, University Medical Center, Ho Chi Minh City, Vietnam, Vu Hoang Anh ,   Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam
Published: August 2024

Background: MicroRNAs (miRs) are emerging targets for the diagnosis, prognosis and treatment of heart failure (HF). Accumulated evidence showed that microRNA-132 (miR-132) and microRNA-152 (miR-152) play critical roles in the development of multiple pathological processes of the heart. Although their upregulations have been detected in the failing hearts of humans and animal models, little is known about the circulating levels of miR-132 and miR-152 in patients with HF. Methods: Our study was conducted from January 2022 to August 2022 at the Cardiology Department of the University Medical Center in Ho Chi Minh City, Vietnam. During study period, 36 participants were consecutively enrolled, including 18 HF patients and 18 patients who age and sex matched the non-HF controls. Serum samples of study participants were collected on admission and the expression levels of miR-132 and miR-152 were measured by quantitative reverse transcription polymerase chain reaction (RT-PCR). The comparative cycle threshold method (ΔCt) was applied to calculate the relative expression of miRs. Results: The miR concentration in HF group was significantly lower than that in the control group. In contrast, the serum levels of miR-132 and miR-152 were significantly higher in HF patients. Further analyses of receiver operating characteristic (ROC) curve showed that miR-132 and miR-152 individually had moderate diagnostic potential for HF (with area under curve [AUC] values of 0.713 and 0.698, respectively). A positive correlation between these miRs was also confirmed. Conclusion: Serum miR-132 and miR-152 were upregulated in Vietnamese patients with HF and may serve as candidate biomarkers for diagnostic purposes.
AVALIAÇÃO MACROSCÓPICA DO SISTEMA DIGESTÓRIO DE JIBOIAS (BOA CONSTRICTOR AMARALI STULL 1932) VIA ENDOSCOPIA DIGESTIVA FLEXÍVEL SOB CONTENÇÃO FARMACOLÓGICA
Authors: Souza Marcos Vinícius de , Botelho Núbia Estéfane Gomes , Júnior Paulo Gabriel Pereira da Silva , Vidal Maria Larissa Bitencourt
Published: August 2024

Inúmeras são as doenças bacterianas, virais, fúngicas, parasitárias e por corpos estranhos que afetam o trato digestivo das serpentes nativas e exóticas, sejam como agentes primários ou secundários. A endoscopia do trato digestório alto e baixo (esôfago, estômago, intestino delgado e intestino grosso) é realizada com um endoscópio flexível, dirigível e fino que possui na extremidade uma micro câmera digital. Objetivou-se avaliar as estruturas do trato digestório alto e baixo, visto que há poucos relatos na literatura nacional sobre avaliação endoscópica flexível em boídeos sob contenção farmacológica. O procedimento proposto mostrou-se plenamente eficaz e de fácil execução em jiboias adultas.
PROPOSTA DE NOVOS ESTEREÓTIPOS NA MODELAGEM DE BANCOS DE DADOS NO CONTEXTO DA LGPD
Authors: Freitas Junior Nilton , Souza Vinícius Jardel Soares de
Published: August 2024

Este trabalho tem por objetivo o alinhamento das técnicas e conceitos de modelagem de bancos de dados relacionais para com as novas normas previstas na legislação da Lei Geral de Proteção de Dados Pessoais, propondo novos estereótipos capazes de auxiliar a modelagem de banco de dados. Devido à presença maciça da Tecnologia da Informação no cotidiano da sociedade moderna, tem-se um aumento considerável do fluxo de dados e das operações de processamento desses dados, muitas vezes capturados por sistemas de informação em ambientes empresariais, através cadastros que são requeridos para a utilização dos recursos dos próprios sistemas. O surgimento da Lei nº 13.709, de 14 de agosto de 2018, chamada de Lei Geral de Proteção de Dados (LGPD) instituiu o objetivo de proteger esses dados com um conjunto de direitos fundamentais, que são a liberdade, a privacidade e o livre desenvolvimento da pessoa natural, tendo como fundamento o respeito à privacidade, intimidade, honra, imagem, liberdade de expressão, dentre outros. Devido às novas regras impostas pela legislação, é possível considerar que processos de desenvolvimento de software também devam se ajustar a novas características de análise, especificamente para a documentação dos modelos de dados. Sendo assim, o desenvolvimento deste trabalho ocorreu através da utilização do modelo entidade-relacionamento, modelo conceitual e modelo lógico, todos aplicados ao levantamento de requisitos para criação de bancos de dados, considerando agora a aplicação dos dois novos estereótipos aos diagramas para a identificação e representação de dados pessoais já no momento da análise de sistemas, observando o princípio Privacy by Design na modelagem de dados.
CAMINHOS POSSÍVEIS DA CRIANÇA PORTADORA DE DOENÇA CRÔNICA NO INTERIOR DO AMAZONAS: RELATO DE EXPERIÊNCIA
Authors: Lopes Amanda Forster , Lima Ivanilde da Silva , De Castro Ckamila Pereira , Lima Sonete da Silva , Costa Murilo Ramos
Published: August 2024

As doenças crônicas são vistas com olhar atento no âmbito da saúde coletiva. Classificadas como agravos à saúde com duração superior a 12 meses e que são suficientemente graves para criar algum grau de limitação de atividade. Ainda, necessitam com frequência de tratamentos longos e por tempo indefinido, com diversas oscilações de intensidade, podendo se tornar condições críticas e levar a alterações do crescimento e desenvolvimento adequados quando sua ocorrência é entre crianças. Assim, o adequado diagnóstico e tratamento durante a infância requer aspectos como organização familiar e a busca por atendimentos, processo que abarca núcleos distintos conforme a complexidade do estado do paciente e os recursos fundamentais para o tratamento, que comumente demanda uma atenção multiprofissional. As dificuldades dos serviços de atendimento de saúde no Brasil reforçam a existência de limitações quanto ao acompanhamento dos casos de doenças crônicas e as dificuldades se tornam maiores quando essa demanda ocorre em regiões que enfrentam particulares desafios no que diz respeito à mobilidade entre municípios, como no interior do Amazonas. Neste contexto, esta pesquisa tem por objetivo descrever a vivência de alunos matriculados na disciplina de Estágio em Nutrição Social, abordar aspectos da realidade observada e realizar um paralelo com as políticas públicas efetivas e demais situações relatadas na literatura. Notou-se que há na região uma elevada carência de profissionais capacitados, infraestrutura inadequada, vulnerabilidade socioeconômica e dificuldades de acesso ao sistema. Observou-se que a região estudada possui peculiaridades e dificuldades no que diz respeito à organização da rede de atenção à saúde. Mediante às falhas existentes, a estrutura da rede de atenção, organização de um fluxograma assim como discussões e direcionamento de ações fundamentadas nas legislações e políticas públicas efetivas são medidas necessárias para possibilitar melhorias desse cenário.
ASPECTOS DAS DIRETIVAS ANTECIPADAS DE VONTADE: O TESTAMENTO VITAL E O MANDATO DURADOURO
Authors: Vinhas Tiago Cação , André Victor Conte , Ferreira dos Santos Juliana , Marques dos Santos Wallef
Published: August 2024

O respeito à autonomia de vontade de pacientes em fase terminal fora a mola propulsora para desenvolvimento da presente pesquisa que versa sobre as Diretivas Antecipadas de Vontade (DAVs). Por meio da bipartição Testamento Vital e Mandato Duradouro, se buscou esclarecer até que ponto o respeito à vontade desses indivíduos pode afetar o direito à vida, visto como absoluto. Nesse sentido, esta pesquisa foi subdividida em segmentos. O primeiro deles objetiva pesquisar os conceitos de Eutanásia, Distanásia e Ortotanásia. No segundo momento é realizada investigação a respeito das DAVs enquanto gênero e espécie. Na terceira subdivisão, por fim, a pesquisa visa esclarecer a perspectiva das DAVs no ordenamento jurídico brasileiro, bem como a abordagem desse instrumento internacionalmente. Para tratar de um assunto tão caro e polêmico, foi utilizado o método da revisão bibliográfica, bem como o estudo da legislação internacional, para entender de que forma as Diretivas Antecipadas de Vontade devem ser compreendidas e como podem ser acolhidas no Brasil. A conclusão a que se chega é que há um progresso obtido com tais instrumentos, embora evidente é a carência de uma norma específica e completa que regulamente o tema.
AUTONOMIA DO PACIENTE EM TEMPOS DE PANDEMIA: O USO (IN)CONTROVERSO DA CLOROQUINA E DA HIDROXICLOROQUINA NO TRATAMENTO DE PACIENTES COM COVID-19
Authors: Vinhas Tiago Cação , André Victor Conte , De Oliveira Gabriel Alves , Alfrediano Luiz Fernando
Published: August 2024

A presente pesquisa tem por objetivo investigar a possibilidade de exercício efetivo da autonomia do paciente no contexto de uma contaminação por coronavírus, bem como o dever de informação que os médicos possuem para obter o consentimento livre e esclarecido do paciente quando o tratamento envolver o uso dos medicamentos Cloroquina e Hidroxicloroquina. Para o desenvolvimento da pesquisa foi utilizado o método da revisão bibliográfica, por meio de um estudo cuidadoso da legislação, de livros dos mais renomados autores e de artigos científicos. Um dos princípios norteadores da discussão é o da autonomia do paciente, posto que esse é fruto de avanços históricos e não pode simplesmente ser desconsiderado. Além de atual, o tema possui elevada relevância, pois há autoridades nacionais em saúde como o Ministério da Saúde que têm adotado protocolos de tratamentos baseados em técnicas contestáveis e opostas às divulgadas por pesquisas e orientações internacionais relatadas pela Organização Mundial da Saúde (OMS) e Agência Nacional de Vigilância Sanitária (ANVISA). Ademais, some-se tal contexto de instabilidade a desinformação em saúde no que compreende a eficácia dos fármacos no tratamento do coronavírus. Em virtude disso, busca-se discutir os reflexos dessas contradições nas decisões que o paciente venha a tomar naquilo que compreende sua saúde, haja vista que o supracitado contexto irradia seus efeitos a toda sociedade. Ao final chega-se à conclusão de  que é dever do médico informar ao paciente sobre todos os prós e contras que envolvem o uso da Cloroquina e Hidroxicloroquina no tratamento da covid-19, pois, somente assim poderá obter o consentimento livre e esclarecido e, consequentemente, possibilitará o efetivo exercício da autonomia do paciente. Outrossim, a ausência de cumprimento do dever de informação possibilita que o médico seja responsabilizado, conforme entendimentos jurisprudenciais brasileiros e Código de Ética Médica.
O AUMENTO DO USO DE AGROTÓXICOS E SEUS REFLEXOS: CONSIDERAÇÕES SOBRE A FLEXIBILIZAÇÃO DA LIBERAÇÃO DO USO DE AGROTÓXICOS E A PL 1459/2022
Authors: Fontes Yago Magalhães
Published: August 2024

Perante ao aumento do uso de agrotóxicos nos últimos anos, a mortandade de abelhas em massa e aos casos de intoxicação por químicos agrícolas, gerou-se a necessidade de analisar a real necessidade do uso desses métodos para proteção das produções agrícolas, métodos esses que são consideravelmente danosos à saúde, ao meio ambiente e também à biodiversidade no que se refere as consequências de seu uso sem uma rigorosa regulamentação ou controle. Portanto, tornou-se preciso compreender de fato o que são os agrotóxicos, o porquê do crescimento de seu uso e principalmente o que levou a criação de um projeto de lei que age a favor da facilitação de para o acesso desses químicos perante ao atual cenário. Entendendo todas as questões e problemáticas envolvidas nesses processos, o atual estudo de metodologia documental qualitativa demonstra essas questões focando em um primeiro momento o que são esses métodos de controle agrícola, seus efeitos nos últimos anos e os reflexos do Projeto de Lei 1459 de 2022 (PL 1459/2022), tendo como base para a execução da análise o próprio documento de PL, também os dados provenientes da organização Greenpeace Brasil, do  Instituto de Pesquisa Econômica Aplicada (IPEA), assim como a Lei 7.802/89 a atual reguladora desses químicos.
RACISMO AMBIENTAL E A GRANDE SÃO PAULO
Authors: Fontes Yago Magalhães
Published: August 2024

A cidade de São Paulo, localizada no estado de São Paulo, e sendo essa conhecida como a maior metrópole brasileira, também é palco das maiores desigualdades sociais do país, desigualdades essas que não se limitam a refletir somente na questão financeira e econômica de sua própria população, mas que também na questão geográfica e ambiental, sendo o âmbito ambiental um dos mais preocupantes. Compreendendo que, cada vez mais as questões ambientais têm se agravado, e assim demonstrado maior relevância e necessidade de compreensão acadêmica, esse estudo através de uma leitura socioambiental tem como proposta apresentar uma questão ambiental que é atrelada ao próprio preconceito étnico, sendo esse o racismo ambiental presente na cidade de São Paulo. Esse artigo científico de metodologia bibliográfica e qualitativa realiza em sua composição uma análise comparativa de alguns dos bairros da cidade de São Paulo, procurando assim denotar o racismo ambiental presente entre eles, uma vez reconhecendo que os bairros mais humildes são de maioria compostos por minorias raciais e econômicas. Em um primeiro momento no decorrer do artigo, é demonstrado e explicado o que é o próprio conceito de racismo estrutural e como ele sustenta, posteriormente são detalhadas suas consequências e como ele afeta a cidade de São Paulo e seus habitantes. Uma vez considerando que, o racismo ambiental por oferecer riscos de moradia, falta de acesso às áreas verdes e menor arborização, ele também se torna danoso à qualidade de vida do cidadão paulista, por negar a ele um ambiente sustentável e seguro.
LITERACIA FAMILIAR: UMA ANÁLISE DAS PRÁTICAS FAMILIARES APOIADAS NA LINGUAGEM PARA O DESENVOLVIMENTO DA TEORIA DA MENTE DAS PESSOAS COM AUTISMO
Authors: Rinaldi Amarante Paula , Rinaldi Leticia
Published: August 2024

A Teoria da Mente, habilidade da Cognição Social, se refere a capacidade de reconhecer, nomear, interferir e prever os estados mentais das pessoas em trocas sociais. Essa mesma aptidão pode ser o cerne das dificuldades sociais das pessoas com autismo, mesmo aquelas com bom funcionamento cognitivo. A literatura traz inúmeras contribuições sobre a importância da interação entre familiares e a contação de histórias como uma relevante prática educacional para o desenvolvimento da linguagem e Teoria da Mente (ToM). A partir dessa relação e com o aporte teórico das pesquisas sobre linguagem, interação, autismo e ToM, pretendeu-se investigar como esses temas têm sido tratados na literatura considerando as dificuldades sociais do Transtorno do Espectro Autista (TEA), da infância até a adolescência. Além disso, também se discute como as famílias podem contribuir para o desenvolvimento da ToM, visando o avanço das habilidades sociais a partir das relações intrafamiliares como forma de complementar práticas clínicas dos terapeutas envolvidos neste trabalho. Este artigo, portanto, se propõe a sintetizar e elencar as principais estratégias de práticas familiares apoiadas na linguagem, embasadas cientificamente, que podem ser realizadas em conjunto pelos pais e seus filhos com TEA.
O PAPEL DA ENFERMAGEM FRENTE AO CÂNCER DE MAMA: PREVENÇÃO, DIAGNÓSTICO E TRATAMENTO
Authors: Da Silva Juliana Santiago , Caroline Lacerda Alves de Oliveira  , Daniele Maria Knupp Souza Sotte  , Roberta Mendes Von Randow  , Natália Tomich Paiva Miranda  , Thiara Guimarães Heleno De Oliveira Pôncio  , Caio Alexsander Silva Oliveira
Published: August 2024

Atualmente no cenário mundial, registra- se um aumento do   número de diagnósticos de câncer de mama, o que causa grande impacto na saúde pública e na qualidade de vida dessas pacientes. O câncer de mama é um tumor maligno que acontece devido a alterações genéticas nas células da glândula mamária. O enfermeiro tem um papel de realizar a educação em saúde tendo assim o conhecimento necessário para realizar o rastreamento e o diagnóstico precoce do câncer de mama. Sendo assim, o objetivo deste trabalho é descrever a assistência de enfermagem na prevenção, detecção e no tratamento do câncer de mama. Trata se de uma pesquisa bibliográfica do tipo revisão integrativa. A busca na literatura foi nas bases de dados da Scienticif Eletronic Library (SCIELO), nos sites do INCA, Biblioteca Virtual de Saúde (BVS), Ministério da Saúde e COFEN sobre a atuação do enfermeiro na prevenção, diagnostico e no tratamento do câncer de mama. O enfermeiro da atenção primária e secundária tem a responsabilidade de aplicar em sua área assistencial seus conhecimentos sobre fatores de risco para o câncer de mama e sobre as medidas de prevenção da doença. Orientar sobre os sinais e sintomas de alerta para o câncer, que percebidos no início levam a um diagnóstico precoce e um prognóstico favorável a cura. Conclusão: Torna-se de suma importância a atuação do enfermeiro para que se tenha uma assistência sistematizada e humanizada, garantindo um atendimento às necessidades do paciente, promovendo seu conforto físico, emocional e espiritual.