bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and Safety of Once-Weekly Efpeglenatide Monotherapy Versus Placebo in Type 2 Diabetes: The AMPLITUDE M Randomized Controlled Trial
Authors: Frias Juan Pablo , Choi JaeDuk , Rosenstock Julio , Popescu Luiza , Niemoeller Elisabeth , Muehlen-Bartmer Isabel , Baek Seungjae
Published: June 2022

Objective: To assess the efficacy and safety of the glucagon-like peptide-1 receptor agonist (GLP-1 RA) efpeglenatide versus placebo in patients with type 2 diabetes inadequately controlled with diet and exercise alone. 

Research design and methods: AMPLITUDE-M was a phase 3, double-blind, placebo-controlled, multicenter trial that randomized adults with type 2 diabetes suboptimally controlled with diet and exercise alone to once-weekly efpeglenatide (2 mg, 4 mg or 6 mg) or placebo for up to 56 weeks. The primary objective was to demonstrate the superiority of efpeglenatide versus placebo for HbA1c reduction at week 30. Secondary objectives included changes in other measures of glycemic control and body weight at weeks 30 and 56. 

Results: At week 30, HbA1c was reduced from a baseline of 8.1% (65 mmol/mol) to 6.9% (52 mmol/mol), 6.6% (49 mmol/mol) and 6.4% (47 mmol/mol) with efpeglenatide 2, 4 and 6 mg, respectively. Least squares (LS) mean HbA1c reductions from baseline were statistically superior for each efpeglenatide dose versus placebo (2 mg: −0.5% [95% confidence interval [CI] −0.9,−0.2; p=0.0054]; 4 mg: −0.8% [95% CI −1.2,−0.5; p<0.0001]; 6 mg: −1.0% [95% CI −1.4,−0.7; p<0.0001]). A greater proportion of efpeglenatide-treated patients (all doses) achieved HbA1c <7% (53 mmol/mol) versus placebo by week 30 (p<0.0001 for all), and significant reductions in body weight and fasting plasma glucose were also observed for efpeglenatide (4 and 6 mg doses) versus placebo at week 30 (p<0.05 for all). Consistent with the GLP-1 RA class, gastrointestinal adverse events were most commonly reported; these were generally transient and mild/moderate in severity. Few patients reported hypoglycemia.

Conclusions: As monotherapy in patients with type 2 diabetes, once-weekly efpeglenatide significantly improved glycemic control and body weight with a safety and tolerability profile similar to other GLP-1 RAs.
Patlamalı Kaynak Yöntemi Kullanılarak Üretilen Bakır-Titanyum Bimetalik Kompozit Malzemelerin Birleştirme Arayüzeyinin İncelenmesi
Authors: YILDIRIM Mehmet Serkan , KAYA Yakup
Published: June 2022

Bu çalışmada, bakır (Cu) ve titanyum (Ti) levhalar patlamalı kaynak yöntemiyle farklı patlayıcı oranları kullanılarak birleştirilmiş ve Cu-Ti bimetalik kompozit malzemeler üretilmiştir. Üretilen Cu-Ti bimetalik kompozit malzemelerin birleştirme arayüzeyi üzerinde patlayıcı oranının etkisi mikroyapı çalışmaları ve mekanik testler ile incelenmiştir. Birleştirme arayüzeyi karakterizasyonu için, optik mikroskop (OM), taramalı elektron mikroskobu (SEM), enerji dağılımlı spektrometre (EDS) ve X-ışını kırınımı (XRD) yöntemleri kullanılmıştır. Birleştirme arayüzeyi mekanik özelliklerini belirlemek için ise çekme-makaslama, çentik darbe, eğme, burulma testleri ve mikrosertlik çalışmaları yapılmıştır. Mikroyapı incelemeleri sonucunda, patlayıcı oranı arttıkça birleştirme arayüzeyindeki dalgalanma arttığı ve bu artışa bağlı olarak da dalga boy ve genliğinde artış tespit edilmiştir. Ayrıca, R=3 patlayıcı oranında Cu4Ti ve Cu4Ti3 R=3.5 patlayıcı oranında ise Cu3Ti2, Cu4Ti3, CuTi2 ve CuTi3 intermetalik fazlarının oluştuğu tespit edilmiştir. Mekanik testler sonucunda ise birleştirme arayüzeyinde gözle görülebilir bir kaynak hatası oluşmadığı belirlenmiştir.
Connections between air pollution, traffic and respiratory health
Authors: Peng Diya
Published: June 2022

Air pollution increases the likelihood of developing a variety of health issues, particularly in the field of respiration. Involuntary exposure to traffic-related air pollution affects humans from fetal development to death. Nitrogen dioxide, sulfur dioxide, carbon monoxide, benzene, ozone, particulate matter 10 (PM10), lead, arsenic, cadmium, nickel, benzopyrene, and particulate matter 2.5 (PM2.5) are among the lung-damaging substances found in air pollutants. Determining the causal relationship between various major road pollutants and the human respiratory system is a difficult task. In general, it can be concluded that traffic-related pollutants will induce an inflammatory response that will progress based on the variation of humans exposed. The concept of oxidative stress resulting from traffic-related pollutants has also begun to receive extensive research. This gives hope for assisting the human anti-oxidant system in combating the increasingly difficult-to-avoid threat of air pollution.
Aplikasi DonasiKu Berbasis Android
Authors: Ulum Muhamad Bahrul , Akbar Habibullah , Azizah Anik Hanifatul
Published: June 2022

Used goods suitable for use are old goods that have been used once or more than once and are still reasonable to be reused. Most of these used goods are no longer used because they already have other, better substitutes. The current management system for these items is usually only collected and stored in the warehouse or even many are left scattered in the corner of the house until the items become a pile. Rather than being left alone, it is better to reuse these items. For example, by donating items that are still reasonable to be reused to people who need it more. Donations in the form of used goods are still poorly managed, information on donation activities that are held is less spread out and if there is, it is not necessarily reliable. So far, the management of the existing donation system is only for donations in the form of money, so the idea of a solution emerged in the form of developing an Android-based donation system application. To analyze the problem used causal analysis based on the data to be collected. The method used for software development is extreme programming. This application can be a solution to the problem of managing the used goods donation system so that people can make donations in the form of goods that are faster, easier to collect and distribute.
Environmental impacts of solar photovoltaic systems: a revision from Life Cycle Assessments and other studies
Authors: Romero Pereira María Carolina , Sánchez Coria Alba
Published: June 2022

According to the 7th goal of sustainable development concluded by the United Nations (UN), energy should become clean and accessible for every human being on the planet in the upcoming decades. Clean energy is often used as a synonym for renewable, sustainable or green energy, words which are associated with a concept of low-impact technologies. However, renewable energies (REs) also have a set of negative environmental impacts (EIs), which can be identified and assessed through an EI Assessment (EIA) and/or a Life Cycle Assessment (LCA). This article focuses on the revision of EIs documented in LCA studies for solar photovoltaic (PV) systems (SPVSs), the most common type of modern REs to satisfy energy demand globally.

Although different LCA studies include various environmental assessment categories, five categories were selected for analysis, namely global warming potential (GWP), land use, biodiversity loss, human health (HH) and waste generation.

The results show that documented EIs of SPVSs from LCAs depend not only on the technology, context and scale of the project, but also on the objective and scope of each study. Still, this article summarizes orientational values for the GWP, land use and fatal bird accidents related to SPVSs. Further, the research reveals the need for complementary approaches such as EIAs or toxicity studies for the assessment of biodiversity loss as well as the impacts on HH, and the lack of an existing waste management system for the million tons of waste soon to be disposed.
Non-dominated NSGA-II genetic algorithm for schedule acceleration considering the discrete time-cost compensation problem (DTCTP) in a construction project
Authors: López Alvaro Cuadros , Villota Rodríguez José Miguel , Velázquez Sánchez José Deyson
Published: June 2022

Sometimes after scheduling a project, it is necessary to shorten its duration. There are many factors that force to crash the duration. Some reasons may be saving costs, early commissioning or avoiding potential risks. In this case, it is necessary to allocate more resources to activities to shorten their duration while trying to invest as little money as possible. The time–cost tradeoff problem is one important problem in project scheduling. In this study the time–cost tradeoff problem is aborded considering a discrete approach and it is solved using a non-dominated genetic algorithm. The application in a construction project identified a Pareto front that managers could use for decision making. Managers were able to analyze different scenarios to meet delivery date, costs, and scope.
Aspects of informing and obtaining consent while conducting trials in pulmonology and psychiatry
Authors: Sinitsina II , Nenascheva NM , Peredelskaya MYu , Sosin DN
Published: June 2022

While obtaining voluntary informed consent from patients with chronic obstructive pulmonary disease (COPD), bronchial asthma and patients presenting with psychiatric symptomology who participate in clinical trials, it is necessary to remember not only about the rights and ethical standards, but also about an extremely vulnerable position of the participants due to their disease specificity. Changes in the mental status of the patients and principal problems of every patient need to be considered. In this article, the aspects of obtaining informed consent from patients with respiratory diseases such as bronchial asthma and COPD and those under psychiatric supervision are reviewed. Apart from general recommendations, every category of patients has its own specific features. Being aware of them will improve doctor-patient communication.
Body mass index of Russian schoolchildren in the second decade of the XXI century
Authors: Levushkin SP , Zhukov OF , Skoblina NA , Skoblina EV
Published: June 2022

The aim of the study is to establish a trend in the body mass index of schoolchildren in different regions of the country. The study was carried out in 2021 as part of the all-Russian monitoring of the physical development of schoolchildren aged 7–17 years (the number of boys - 30,965, the number of girls - 33,290). The statistical software package Statistica 13 PL has been used for data processing. BMI indicators have been established for Russian schoolchildren. Some regional differences in BMI indicators and the influence of the organization of medical support factor in the region have been shown. The Pearson correlation coefficients between the BMI of schoolchildren and the availability of doctors and nurses per 10,000 of population were -0.63 and -0.39 (p ≤ 0.05). The age and gender standards for BMI for Russian schoolchildren have been updated. A trend towards higher BMI rates in various subjects of the Russian Federation has been revealed, which may be due, among other things, to indicators characterizing the organization of the medical population in the region.
Коефіцієнти транзитивності частково впорядкованих множин найвищого суперкритичного MM-типу
Authors: Бондаренко В. М. , Стойка М. В. , Стьопочкіна М. В.
Published: June 2022

Зображення частково впорядкованих (скорочено ч. в.) множин, які введені Л. А. Назаровою і А. В. Ройтером (в матричній формі) в 1972 р., відіграють важливу роль в сучасній теорії зображень. У своїй першій праці за цією тематикою М. М. Клейнер довів, що ч. в. множина S має скінченний зображувальний тип (тобто має скінченне число нерозкладних зображень, з точністю до еквівалентності) тоді і лише тоді, коли вона не містить ч. в. підмножин вигляду K1= (1, 1, 1, 1), K2 = (2, 2, 2), K3 = (1, 3, 3), K4 = (1, 2, 5) і K5 = (N, 4). Вказані ч. в. множини називаються критичними ч. в. множин щодо скінченності типу (тобто вони є мінімальними ч. в. множинами з нескінченним числом нерозкладних зображень, з точністю до еквівалентності). Їх також називають (критичними) ч. в. множинами Клейнера. У 1974 р. Ю. А. Дрозд довів, що ч. в. множина S має скінченний зображувальний тип тоді і лише тоді, коли її квадратична форма Тітса

є слабко додатною (тобто додатною на множині невід'ємних векторів). Таким чином, ч. в. множини Клейнера є критичними щодо слабкої додатності квадратичної форми Тітса, і інших таких ч. в. множин немає (з точністю до ізоморфізму). У 2005 р. автори довели що ч. в. множина є критичною щодо додатності квадратичної форми Титса тоді і лише тоді, коли вона мінімаксно ізоморфна деякій ч. в. множині Клейнера.
Подібну ситуацію маємо з ч. в. множинами ручного зображувального типу. У 1975 р. Л. А. Назарова довела, що ч. в. множина S є ручною тоді і лише тоді, коли вона не містить ч. в. підмножин вигляду N1 = (1, 1, 1, 1, 1), N2 = (1, 1, 1, 2), N3 = (2, 2, 3), N4 = (1, 3, 4), N5 = (1, 2, 6) і (N, 5). Вона назвала ці ч. в. множини суперкритичними; вони є також критичними щодо слабкої невід'ємності квадратичної форми Тітса. У 2009 році автори довели, що ч. в. множина є критичною щодо невід'ємності квадратичної форми Тітса тоді і лише тоді, коли вона мінімаксно ізоморфна деякій суперкритичній ч. в. множині.
У цій статті вивчаються комбінаторні властивості ч. в. множин, мінімаксно ізоморфних суперкритичній ч. в. множині найбільшої висоти, тобто (1, 2, 6). Важливість вивчення мінімаксно ізоморфних ч. в. множин визначається тим фактом, що їх квадратичні форми Тітса ℤ-еквівалентні, а сам мінімаксний ізоморфізм є досить загальною конструктивно визначеною ℤ-еквівалентністю для квадратичних форм Тітса ч. в. множин.
Метод машинного навчання для створення нових лікарських речовин із заданими властивостями
Authors: Гурбич О.
Published: June 2022

Створення нових біологічно активних речовин є однією із найважливіших проблем фармацевтичної галузі. У цій статті запропоновано метод, у якому поєднуються кілька глибоких нейронних мереж для генерування унікальних молекул із заданими властивостями. Генерування доповнюється виправленням хімічної будови молекул із помилками за допомогою рекурентної нейронної мережі з механізмом уваги. Для створених молекулярних структур проведено аналіз хімічних властивостей та оцінку схожості на лікарські речовини. Запропонований ансамбль дозволяє створювати нові унікальні лікарські речовини, контролюючи ступінь розчинності та інші молекулярні дескриптори.
Дослідження поля впливу пружних переміщень і напружень для попередньо напруженної смуги від дії зосередженої сили
Authors: Діхтярук М. М. , Кравчук О. А.
Published: June 2022

В даній статті в рамках лінеаризованної теорії пружності досліджується вплив пружних переміщень і напружень для пружної смуги з початковим (залишковим) напруженням від дії зосередженої сили. Розглядаються випадки коли сила діє під довільним кутом α, коли на попередньо напружену смугу діє тільки вертикальна сила і випадок дії тільки горизонтальної сили. Отримано систему розв'язуючих інтегрально- диференційних рівнянь, для пружної смуги з початковими напруженнями підсиленої пружним скінченним стрингером. Для випадків відсутності горизонтальних навантажень, або вертикальних навантажень система зведена до розрахункових інтегрально- диференційних рівнянь. Всі дослідження виконані в рамках лінеаризованої теорії пружності для стисливих і нестисливих тіл, у випадку пружних потенціалів довільної структури, в загальному вигляді для теорії великих (скінченних) початкових деформацій і двох варіантів теорії малих початкових деформацій.
Врахування залишкових деформацій при розрахунку важливих елементів конструкцій, машин та споруд дозволяє більш точно оцінювати запас міцності матеріалу, а отже, суттєво зменшити його витрати, зберігаючи при цьому необхідні функціональні характеристики елементів в цілому. Саме тому дослідження контактної взаємодії пружних тіл із залишковими деформаціями є надзвичайно актуальним завданням сьогодні та залишатиметься таким у майбутньому. Дослідження проблем контактної взаємодії попередньо напружених тіл у нашій країні та закордоном появились у достатній кількості лише наприкінці минулого століття. В першу чергу, це пов'язано із тим, що лінійна теорія пружності не враховує наявності у тілах залишкових напружень. У загальному випадку строга постановка таких задач потребує застосування апарату нелінійної теорії пружності, проте, при достатньо великих значеннях початкових напружень можна обмежитись її лінеаризованим варіантом. Сучасний рівень лінеаризованої теорії пружності та математичних методів у сукупності із бурхливим розвитком комп'ютерної техніки дають можливість ефективно формувати різноманітні розрахункові моделі стосовно широкого кола задач.
Алгоритм побудови базисної решітки класу M₂ булевих алгебр
Authors: Мич І. А. , Ніколенко В. В. , Варцаба О. В. , Динис В. С.
Published: June 2022

У даній роботі продовжується дослідження базисної решітки класу алгебр M2. Базисну решітку класу M2 можна побудувати з сигнатурної решітки цього класу. Базисні решітки є фактор решітками відповідних сигнатурних решіток. У даній роботі наводиться алгоритм побудови базисної решітки (фактор- решітки) класу алгебр M2, наводиться повна інформація про базисну решітку у вигляді таблиць, які вказують розташування суміжних класів і ребер, що їх з’єднують.
Дослідження розв'язків інтегральних крайових задач
Authors: Варга Я. В. , Рего В. Л. , Семчишин Г. Я.
Published: June 2022

У даній статті обгрунтований оригінальний метод побудови чисельно-аналітичної схеми дослідження розв'язків нелінійних систем звичайних диференціальних рівнянь, підпорядкованих нелінійним інтегральним крайовим умовам. В основі методу лежить перехід від заданих інтегральних крайових умов до параметризованих умов модельного типу, які мають простий вигляд початкових умов. Для модельної параметризованої задачі побудована конструктивна чисельно-аналітична схема, яка базується на параметризованих послідовних наближеннях із покращеними характеристиками збіжності. Встановлено зв'язок між розв'язками модельної та вихідної крайових задач. Доведено, що діленням відрізка інтегрування навпіл у два рази можна покращити достатні умови рівномірної збіжності параметризованих послідовних наближень. Цю техніку та її переваги продемонстровано на прикладі інтегральної крайової задачі, в якій для виконання достатніх умов збіжності потрібно поділити відрізок інтегрування навпіл.
Моделювання гауссового стаціонарного випадкового процесу з необмеженим спектром з використанням теорії L₂(Ω)-процесів
Authors: Тегза А. М. , Сливка-Тилищак Г. І. , Герич М. С. , Погоріляк О. O. , Боярищева Т. В.
Published: June 2022

Робота присвячена подальшому розвитку теорії моделювання гауссових стаціонарних випадкових процесів за методом, який запропонував і розвивав Ю. В. Козаченко. Розглянуто застосування теорії L2(Ω)-процесів при моделюванні гауссових стаціонарних випадкових процесів. Використовуючи оцінки норм та деякі властивості і теореми L2(Ω)-процесів, для моделі одержано розбиття спектрального проміжку, при якому модель наближатиме процес з заданими точністю і надійністю в рівномірній метриці. У середовищі Python було змодельовано процес для часткового випадку.
Reseña del libro Clemente Quijada, Luis. El mundo rural extremeño (SS. XIII-XVI). Paisaje, sociedad y poderes en el Maestrazgo de Alcántara. Badajoz: Diputación de Badajoz, 2020 (pp. 421)
Authors: Luchía Corina Julia
Published: June 2022

Reseña del libro El mundo rural extremeño (SS. XIII-XVI). Paisaje, sociedad y poderes en el Maestrazgo de Alcántara de L. Clemente Quijada.
Salta (Argentina): una ciudad para ver desde la altura. El Cerro San Bernardo como punto panorámico y turístico
Authors: Troncoso Claudia Alejandra
Published: June 2022

El trabajo analiza los procesos por los cuales el cerro San Bernardo (Salta) deviene un punto de observación turística (atendiendo a acondicionamientos materiales, imágenes y prácticas). Para ello se relevó y sistematizó información respecto de la promoción del cerro como punto de observación (y de la ciudad como atractivo); se procedió a la observación y registro de las actividades de los turistas en su cima; y se llevaron adelante entrevistas con actores del sector público y privado vinculados con el turismo en la ciudad. Se concluye que las formas de apreciación visual desde la cima recuperan algunos usos ya instalados en el turismo respecto de qué hacer y cómo en localizaciones en altura (miradores), al tiempo que se señala la necesidad de pensar estos ámbitos y las prácticas de observación en el conjunto de actividades que definen la visita a estos lugares.
Territorialidades periurbanas. Aportes y reflexiones teórico metodológicas a partir de un caso de estudio en La Plata (Buenos Aires, Argentina)
Authors: Mosca Valeria Ana
Published: June 2022

El artículo busca aportar una propuesta teórico-metodológica para abordar a los periurbanos desde un enfoque territorial. Para ello se indaga en los actores sociales que producen estos territorios utilizando el concepto territorialidades, el cual se operacionaliza a partir de una serie de dimensiones. Con ello analizamos un estudio de caso en el periurbano de La Plata (Buenos Aires, Argentina) poniendo en práctica la propuesta realizada. Utilizamos una metodología cualitativa, a partir de la sistematización de fuentes primarias y secundarias, buscando combinar aportes de los estudios urbanos y rurales. Las conclusiones aportan reflexiones sobre las características que asume la producción social del territorio periurbano para el caso de estudio y el rol de los actores sociales en dicho proceso.
Aptitud climática de un destino turístico semiárido. Primera aproximación sobre un caso argentino
Authors: Tanana Ariadna Belén
Published: June 2022

El abordaje de la relación clima-turismo se ha expandido a través de la Climatología del Turismo, aunque las experiencias en destinos del hemisferio sur son escasas. Este artículo evalúa el confort bioclimático y climático-turístico de Mendoza, destino internacional de clima semiárido representativo de la región Cuyo. Se utilizó un enfoque cuantitativo basado en índices directos: bioclimáticos (complejo termo-higrométrico, complejo temo-anemométrico y temperatura equivalente) y climático-turísticos (Tourism Climate Index y Holiday Climate Index Urban). Para ello, se emplearon los datos medios mensuales de las últimas tres décadas disponibles (1981-2010). Conforme con los resultados, el verano es un momento crítico en términos del confort térmico. Sin embargo, según los índices climático-turísticos el destino es apto durante todo el año, aunque se contraponen con respecto al momento calificado como ideal para el turismo, poniendo en discusión su aplicabilidad en destinos de clima semiárido.
La mercantilización del territorio en el municipio de Huamantla, Tlaxcala, México
Authors: Cabrera Luis Ricardo , Palacio-Aponte Alvaro Gerardo , Vazquez Solís Valente
Published: June 2022

El turismo en México es un sector económico consolidado, sin embargo, para el estado de Tlaxcala se considera una actividad económica emergente. Pese a esto, la entidad oferta una amplia variedad de atractivos turísticos como la exhacienda premier de San Francisco Soltepec, el Santuario de las Luciérnagas, el pueblo estilo toscano de Val’Quirico, además de los Pueblos Mágicos de Tlaxco y Huamantla. Este artículo explica el proceso de mercantilización del municipio de Huamantla con el fin de adherirse al circuito del mercado turístico nacional. Para tal efecto, se extrajeron indicadores territoriales de los años 2015 y 2021 relacionados con la reconversión del capital, agentes con mayor capacidad de inversión y cambios, tanto en actividades económicas como en el paisaje rural, con el fin de contrastarlos y demostrar la celeridad de dicho proceso. Los resultados hallados indicaron que, si bien Huamantla se inclinó por un perfil turístico a raíz del nombramiento como Pueblo Mágico en 2007, el municipio consolidó la mercantilización del territorio gracias al impulso económico generado por el sector industrial algunos años después. De esta manera, la instalación, a partir del año 2016, de la automotriz Audi y los parques industriales fueron tomados en consideración para el caso de estudio.
Habitus in the context of transfer of students from central Mexico to tourist destinations during the COVID-19 era
Authors: García Lirios Cruz , Quiróz Campas Cellia Yaneth , Espinoza Morales Francisco , Carreón Guillén Javier , Sánchez Sánchez Arturo , Rosas Ferrusca Francisco Javier
Published: June 2022

Habitus is a disposition towards a risk. In the case of the pandemic, the habitus of transfer and stay suggests contexts that the present work addresses to observe them in a sample of students. A cross-sectional, exploratory, and non-experimental study was carried out. The sample consisted of 100 students with an average age of 20 years old, a monthly income of 1,781.89 USD and an average 150 minutes commute time from residence to school. A structure of five factors that explained the effects of state communication on the use of public transport was found. It is hoped that the model can extend the dimensions of the habitus to other research settings.
¿Misma cara de una moneda?
Authors: Paredes Suito Silvia
Published: June 2022

Es preciso aprovechar la dimensión social en la gestión del Patrimonio Mundial, y para ello, es fundamental que los ciudadanos se involucren. Sin embargo, el ejercicio de la participación desde el punto de vista institucional ha minimizado la visión en torno a su condición integradora para la transformación social. Este artículo explora hasta qué punto la estimación de los impactos sociales, generados en las intervenciones que buscan impulsar el uso social y turístico, consideran la perspectiva de las comunidades. A partir de una investigación bibliográfica, se realizó un análisis y selección de indicadores aplicados en casos de estudio identificaron las convergencias entre los impactos sociales y las respuestas obtenidas desde la percepción de las comunidades participantes.
Research on foot anthropometry of men with diabetes in Vietnam
Authors: BUI Van-Huan , CAO Thi-Kien-Chung , NGUYEN Hai-Thanh , PHAN Duy-Nam , LE Thanh-Xuan
Published: June 2022

Diabetes often causes foot complications, inducing diabetic patients to use therapy shoes or custom-made shoes designed on the basis of anthropometric characteristics of their feet to ensure a good fitting. Wearing poorly fitted shoes contributes to the development of foot ulcer sites. This paper presents the results of foot anthropometric research, developing a foot size system for men with diabetes in Vietnam in order to develop pressure-offloading footwear. The foot data of 212 men with type-2 diabetes aged 44 to 75 years were collected during this study. Foot photography and patient interviews about foot complications were also conducted by research assistants. The results show that the average disease duration of the surveyed patients was statistically calculated as 6.8 ± 4.3 years. The patients from 50 to 70 years old accounted for up to 86.8% of all interviewees. In all participants, the patients with foot pain and swelling of metatarsal joints accounted for 19.8%, foot ulcers accounted for 6.4%, dry feet, cracked skin, and calluses almost equally accounted for 12%. Most of the feet are slightly deformed mainly in the metatarsal joint area and no patient had a leg amputation. The patients suffering from two types of foot injuries account for more than 43.1%. Interestingly, the ball width and circumference of the patient’s foot are 4.5 mm and 6.5 mm larger than that of a healthy man’s foot, respectively; whereas, the mid-foot height is 3.7 mm lower. From the collected data and statistic figures, the patient foot sizing system has been developed including 5 sizes by length (231.5, 238.0, 244.5, 251.0, 257.5 mm), and each size by length is divided into 3 sizes by width. Our categorizing system meets more than 81.5% of the shoe size needed by men with diabetes in Vietnam.
Polymer composite based on NBR rubber compounded with rubber waste functionalized with potassium oleate
Authors: NIŢUICĂ Mihaela , STELESCU Maria Daniela , SÖNMEZ Maria , ALEXANDRESCU Laurenția , GEORGESCU Mihai , GURĂU Dana , PANTAZI-BĂJENARU Mirela
Published: June 2022

Waste is a material that occurs as a result of a biological or technological process that can no longer be used as such. Recycling and reusing waste make it possible to contribute to environmental protection and, of course, to the protection of human health by eliminating toxins during waste incineration. The purpose of this paper is to process and characterize polymer composites based on NBR rubber (butadiene-co-acrylonitrile rubber) and rubber waste functionalized with potassium oleate in terms of rheological characteristics (to determine the optimal vulcanization time), Brabender diagrams and physico-mechanical properties in normal state and after accelerated ageing at 70°C, for 168 h (using elastomer-specific equipment). Functionalized rubber waste (with potassium oleate up to 20% at 60°C) is introduced into the mixture in proportions of 10; 20; 30; 50%. The polymeric composites based on butadiene-co-acrylonitrile elastomer and rubber waste (ground with a cryogenic mill at 10,000 rpm, at the size of 0.35 mm) were compounded on a mixer with a capacity of 350 cm3 according to the working recipes. The mixtures were supplemented with vulcanization activators and accelerators on an electric roller, resulting in formulations in the form of 4 mm thick sheets, which are then subjected to the relevant characterizations according to the standards in force for the footwear industry.
Two new taxa of the genus Dichagyris Lederer, 1867 from the Caucasus (Lepidoptera, Noctuidae)
Authors: Gyulai Péter
Published: June 2022

Description of Dichagyris korshunovi dagestana ssp. n. and Dichagyris inequalis sp. n. from Dagestan, Russia are given with 16 colour photos of imagines and 14 genitalia figures.
Geographical distribution and bionomics of the Zygaenids of Hungary with illustrations (Lepidoptera: Zygaenidae)
Authors: Fazekas Imre
Published: June 2022

The study is a comprehensive synthesis of information on 26 known Hungarian species of Zygaenids. This work is used as a guide for the distribution maps of the Zygaenidae species. It is the second summary work on the geographical distribution of Hungarian species. The preparatory work for this study was started 40 years ago with planned collecting activities, revisions of museum, institutional and private collections, and writing of faunistic monographs on Zygaenids from several geographic regions. Colour photographs of the species are included.
Eugnorisma depuncta (Linnaeus, 1761) és a Dryobotodes monochroma (Esper, 1790) elterjedése Magyarországon és a Dél-Dunántúlon
Authors: Fazekas Imre
Published: June 2022

This study investigates the geographical distribution and bionomics of two noctuid moths, Eugnorisma depuncta (Linnaeus, 1761) and Dryopbotodes monochroma (Esper, 1790), which occur sporadically in Hungary. It summarizes the results of the research conducted so far. It describes the habitats, the flight period and the food plants. It illustrates the wing pattern of the imago and shows the genitalia. It presents the differential features of the wings and genitalia of similar species. The geographical distribution of the European sites is shown on two maps. The Hungarian distribution of two noctuid species is given by summarizing all available locality data on Google maps. The study includes 14 very detailed figures that make it easier to distinguish between similar species.
New taxa of the genus Dichagyris Lederer, 1867 (Lepidoptera, Noctuidae) from Asia
Authors: Gyulai Péter
Published: June 2022

Description of six new species and nine new subspecies of Dichagyris Lederer, 1867, with 64 colour illustrations and 57 genitalia figures.
Growing Beagles and Foxhound-Boxer-Ingelheim Labrador Retriever mixed breeds show a forelimb-dominated gait and a cranial shift in weight support over time during a kinetic gait analysis
Authors: Mall Sandra U. , Steigmeier-Raith Stephanie , Reese Sven , Meyer-Lindenberg Andrea
Published: June 2022

OBJECTIVE

To collect kinetic gait reference data of dogs of 2 breeds in their growth period during walking and trotting gait, to describe their development, and to investigate the weight support pattern over time.

ANIMALS

8 Foxhound-Boxer-Ingelheim Labrador Retriever mixed breeds and 4 Beagles.

PROCEDURES

Ground reaction force variables (GRFs), peak vertical force and vertical impulse, and temporal variables (TVs) derived therefrom; time of occurrence; and stance times were collected. Body weight distribution (BWD) was evaluated. Six measurements, each containing 1 trial in walking and 1 trial in trotting gait, were taken at age 10, 17, 26, 34, 52, and 78 weeks. The study period started July 17, 2013 and lasted until October 7, 2015. Area under the curve with respect to increase was applied. The difference of area under the curve with respect to increase values between breeds and gaits was analyzed using either the t test or the Mann-Whitney test. Generalized mixed linear models were applied.

RESULTS

Significant differences in gait and breed comparisons were found. Growing dogs showed a forelimb-dominated gait. The development of GRF and TV values over the study period were described.

CLINICAL RELEVANCE

Reference values for GRFs, TVs, and BWDs in growing dogs were given. A cranial shift in weight support over time was found during trotting gait. Smaller, younger dogs walked and trotted more inconsistently.
First report of the presence of enterotoxin gene in coagulase-negative staphylococci recovered from meat of snails (Achatina achatina)
Authors: Okafor Arthur C. , Ogbo Frank C. , Akharaiyi Fred C. , Oladeinde Henry B.
Published: June 2022

Introduction

It has been suggested that coagulase-negative staphylococci can serve as reservoirs of virulence genes for other bacteria. This study assessed the presence of such genes in selected isolates recovered from meat of the giant African snail (Achatina achatina).

Material and Methods

Virulence genes were detected using a polymerase chain reaction targeting specific primers. Two representative isolates were identified using 16S rRNA gene sequencing.

Results

The results showed that the staphylococcal enterotoxin A gene (sea) was present in five out of the eight isolates studied. The isolates expressed resistance mainly to three antibiotics: chloramphenicol, norfloxacin and cloxacillin in descending order of incidence. Most importantly, the Staphylococcus sciuri isolate NEDU 181, in addition to being resistant to the three aforementioned antibiotics, also harboured the sea gene.

Conclusion

Our findings demonstrate, for the first time, the presence of toxigenic and antibiotic-resistant coagulase-negative Staphylococcus spp. in commercially-available fresh snail meat. With staphylococcal enterotoxin A known to survive cooking temperature, this presents a food safety concern.
Metacognitive awareness and emotional resilience in children with Attention Deficit Hyperactivity Disorder
Authors: Ünver Hatice , Rodopman Arman Ayşe , Nur Akpunar Şerife
Published: June 2022

Background

This study explored the metacognitive awareness and emotional resilience levels of children suffering from attention deficit hyperactivity disorder (ADHD) (n=60) with typically developing children (n=30).

Methods

Measures included Metacognitive Awareness Inventory and Resiliency Scales for Children and Adolescents filled out by participants, the List of Adverse Life Events, Turgay DSM-IV-Based Disruptive Behavior Disorders Scale, and Revised Child Anxiety and Depression Scale—Parent Form filled out by parents.

Results

Metacognitive awareness and emotional resilience were found to be low in the children with ADHD. Emotional resilience increases as metacognitive awareness increases. Metacognitive awareness decreased in the presence of heightened ADHD, anxiety, and/or depression symptoms expressed by the parents' questionnaires (p < 0.001, r = −0.438; p < 0.001, r = −0.403; and p < 0.001, r = −0.421).

Conclusions

Findings identified that metacognitive skills and emotional resilience are affected in ADHD.
The Difficulty Of Physics Education Students Class 2018 In Studying Quantum Physics Courses Online
Authors: Almianai Rini , Soewarno Soewarno , Farhan Ahmad , Musdar Musdar
Published: June 2022

Problem-solving in the Quantum Physics course which requires a very mathematical description and analysis is considered difficult by students, especially if the learning is done online. This study aims to find out the difficulties of learning Quantum Physics courses through online learning for physics education students in class 2018 FKIP USK. The subjects in this study were students of physics education class 2018 who took the Quantum Physics course, totaling 49 people. The research approach used is descriptive quantitative. Data collection was carried out using a closed questionnaire based on the google form. The results showed that students had learning difficulties using online learning in the Quantum Physics course from internal factors, namely cognitive indicators with a total score of 841 while external factors, namely community environmental indicators, with a total score of 457. Conclusions Based on the difficulties experienced by students in this study, it can be seen that students have some difficulties in studying Quantum Physics material online.
Clinical Chemistry and Biochemistry: The Role of Biomarkers and Biomolecules
Authors: AHSAN HASEEB
Published: June 2022

Biochemistry is a branch of biosciences which deals with the study of chemical reactions that occur in living cells and organisms. It is a subject in which biological phenomenon is analyzed in terms of chemical reactions or metabolic pathways. Biochemistry has been previously named as biological chemistry, chemical biology, clinical chemistry, chemical pathology, physiological chemistry, including medical biochemistry and clinical biochemistry. Medical biochemistry studies the chemical composition and physiological reactions in the human body. Clinical biochemistry is the measurement of chemicals or analytes in body fluids for the diagnosis, monitoring and management of patients with various diseases such as diabetes, cardiovascular diseases, etc. An increase in the number and availability of laboratory diagnostics has helped in the solution of clinical problems. Particularly important is the contribution of clinical chemistry to the diagnosis and monitoring of diabetes. The importance of lipids and lipoproteins for public health has increased with clinical studies showing the benefit of lipid lowering in cardiovascular diseases. An understanding of clinical chemistry and biochemistry would be useful in the study of medical and allied sciences for the advancement of knowledge in academic and professional courses. This review article is an attempt to understand the scope and significance of basic and applied aspects of biochemistry
Prognostic factors pertaining to disease-free status in differentiated thyroid carcinoma patients
Authors: Jabeen Aniqa , Jadoon Lubna , Mushtaq Sumaira , Maqbool Syed , Ahmed Bashir , Hashmi Hina
Published: June 2022

Background: Radioiodine resistance in differentiated thyroid cancer (DTC) and unsuccessful ablation may adversely affect the prognosis of patients with DTC; therefore, identifying the factors that affect the success of ablation is very important in the management of patients with DTC. Our goal was to assess the factors associated with DTC after thyroidectomy and radioactive iodine ablation for achievement of disease-free status.
Methods: This was a retrospective study in which 277 patients were included. Age, gender, extent of thyroid surgery, tumor size, nodal metastases, distant metastases, and pre-ablation thyroglobulin (Tg) were analyzed initially in univariate analysis and then with significant variables by multivariate analysis.
Results: On univariate analysis, variables such as pre-ablated stimulated Tg level ≤ 20 ng/ml, absence of locoregional and distant metastases, tumor ≤ 4 cm, total thyroidectomy, and low and intermediate risk groups appeared to be significant. On multivariate analysis, stimulated Tg level ≤ 20 ng/ml, absence of locoregional metastases, and total thyroidectomy were associated with disease-free status.
Conclusion: The most important predictors for succeeding a disease-free status were low pre-ablation Tg level, i.e., 20 ng/ml, appropriate total thyroidectomy, and absence of lymph node metastasis.
Digital transformation of higher education from the standpoint of interdisciplinary approach: review of humanitarian studies
Authors: Bermus Aleksandr Grigorievich
Published: June 2022

The purpose of the study is to identify the actual problems in the field of digital transformation of higher education, studied by modern scientists – teachers, psychologists, sociologists, philosophers, economists. A theoretical and methodological review of the authors' positions and interpretations of the problems under study related to the process of digitalization of education in a digital society is presented. The advantages and risks of the digital transformation of higher education are assessed. The scientific novelty lies in the fact that the author has analyzed the latest (2019-2021) Russian scientific sources in the humanities and pedagogy from the standpoint of an interdisciplinary approach. As a result, key areas of research of digitalization processes in education were identified, aimed at updating the content, forms and methods of professional training in higher education in the context of digital realities.
Development of the shadow economy in the construction sector during the pandemic
Authors: Severukhin Kirill Valeryevich
Published: June 2022

The purpose of the study is to analyze the scale of development of the shadow economy in the construction sector during the pandemic. The article presents the dynamics of shadow financial transactions in the construction industry in the period 2020-2021. The scientific novelty lies in forecasting the development potential of the shadow economy in a pandemic, including the construction sector of the economy. As a result, it was revealed that in the structure of the branches of the Russian economy that formed the demand for shadow financial services during the pandemic, the construction sector is in the first place. An analysis of the growth rates of construction works in 2020-2021 showed that anti-pandemic restrictive measures still slowed down the positive dynamics in the construction sector. Reducing the volume of the shadow economy in the construction sector must be carried out comprehensively, including, on the one hand, identifying the benefits of leaving the "shadow sector", while improving, on the other hand, official institutions.
FORMULATION AND EVALUATION OF PRONIOSOMAL TOPICAL ANTIFUNGAL GEL OF MICONAZOLE NITRATE
Authors: Mahajan Suvarnalata S. , Chaudhari Rajesh Y. , Patil Vijay R.
Published: June 2022

Proniosomal gel formulations of miconazole nitrate (MCZ) were prepared by using combinations of different grades of (non-ionic surfactant) span, cholesterol, and lecithin by coacervation phase separation method. Developed 10 proniosomal gel formulations were characterized for particle size, shape, % entrapment efficiency, drug content, in vitro drug permeation, scanning electron microscopy (SEM), DSC, stability study. The fourier transform infrared spectroscopy (FTIR) studies confirmed the compatibility of the drug with excipients. The results showed that all the formulations were pale yellow to pale brown in color, pH was is in the range of 5.60 to 7.20, and encapsulation efficiency was found is in the range of 83 to 91.25% and particle size in between 5.81 ± 0.2 to 07.52 ± 0.07. Among the ten formulations MF2, MF3, MF5, MF6, and MF8 showed maximum drug release in a controlled manner at 12 hours of study and developed into carbopol proniosomal topical gel and evaluated for ex-vivo drug permeation. Formulation-optimized formulation C5MF8 showed higher drug permeation 74.19 ± 0.16% at 12 hr. with a flux value of 6.829 ± 0.12 μg/cm2/hr. The permeability coefficient of 0.341 ±0.08 cm2/hrs., higher correlation coefficient R2 0.9944 for zero-order drug release kinetic model, and follows zero-order release kinetics. Among the 5 formulations, optimized carbopol proniosomal topical gel formulation C5MF8 drug release and in-vitro antifungal activity was compared with marketed formulation cream.C5MF8 showed sustain drug release and zone of inhibition value was very near to marketed preparation. Hence it was concluded that developed carbopol proniosomal topical gel had the potential to act as a controlled release drug carrier, which sustains the drug release for many hours and exhibit good antifungal activity.
DEVELOPMENT AND CHARACTERIZATION OF SILDENAFIL CITRATE ORAL THIN FILMS
Authors: Yadagiri Divya Jyothi , Kuchkuntla Mounika , Konatham Moounika , Gorle Mounika Tejaswi , Bakshi Vasudha , Jadi Rajendra Kumar
Published: June 2022

The current work aimed to develop sildenafil citrate (SC) oral thin films. SC oral thin films (OTF) were prepared by solvent casting method. The ingredients include hydroxypropyl methylcellulose (HPMC), E4 (as film former), glycerol (as lubricating agent), polyethylene glycol 600 (as plasticizer), rose oil (as flavoring agent), and de-ionized water (as solvent). The SC-OTFs were successfully prepared by the solvent casting method. The drug excipient compatibility studies showed the absence of drug excipient interactions in fourier transform infrared spectroscopy (FTIR) spectra. All the prepared formulations (F1 to F6) were evaluated for several physicochemical parameters like morphology (i.e., size, shape, color), thickness, uniformity (i.e., content and weight), surface pH measurement, in vitro disintegration time, in vivo studies (i.e., taste), tensile strength, folding endurance and in vitro drug release and all were found within pharmacopoeial limits. In vitro, drug release studies (F1 to F6) in simulated salivary fluid (6.8 pH phosphate buffer) showed that 98 ± 1.26% drug was released from F4 in 60 sec. The OTF is a promising formulation for SC that results in high solubility, rapid onset of action, and enhanced systemic bioavailability (BA).
FORMULATION AND EVALUATION OF SOILD LIPID NANOPARTICLES OF SERTRALINE HYDROCHLORIDE
Authors: Hangargekar Sachin R. , Mohanty Pradeep K. , Jain Ashish
Published: June 2022

Depression is a global affective and common mental disorder, with over 264 million people experiencing it. It is characterized by depressed mood, loss of interest, feelings of guilt or low self-worth, disturbed sleep or appetite, and poor concentration. A new class of colloidal delivery system has been introduced that encompasses a number of advantages over the conventional dosage forms and one of it includes the solid lipid nanoparticles (SLN) with the major advantage of been controlled and site-specific drug delivery. It is made up of a solid core and phospholipid shell having high drug loading to enhance bioavailability. Sertraline hydrochloride is an antidepressant drug used for brain targeting. The main objective of the work was to formulate Sertraline hydrochloride-loaded solid lipid nanoparticles and to screen the effect of formulation with process variables on the performance of these formulated solid lipid nanoparticles. Hot homogenization technique was used to formulate the solid lipid nanoparticles using of 32 factorial designs. The effect of independent variables on the concentration of Poloxamer 188 and Glyceryl monosterate on viscosity and drug release was studied. SLNs containing sertraline hydrochloride were prepared and evaluated. The results depicted F6 as an optimized formulation with an entrapment efficiency of 87.36 ± 1.45% and a drug release of 84.26 ± 1.10%. With the thorough screening study, the enrichment of Sertraline hydrochloride entrapment was attained with good particle size and controlled release. The factorial design confirmed its influence and significance in determining and understanding both formulation and process variables affecting the quality of SLNs.