bluuebunny/crossref_metadata_2025 huggingface dataset:
Estimulación espinal para la espasticidad: enfoques históricos, estado actual y tendencias futuras.
Authors: Nagel Sean J. , Wilson Saul , Johnson Michael D. , Machado Andre , Frizon Leonardo , Chardon Matthieu K. , Reddy Chandan G. , Gillies George T. , Howard III Matthew A.
Published: January 2024

Introducción: La espasticidad es una condición relacionada a daño cerebral o de la médula espinal que afecta a millones de personas en el mundo, causada a menudo por eventos como accidente cerebro – vascular, daño traumático cerebral o medular, aunque es también común un comienzo insidioso del padecimiento. Sin desmedro de la causa, la espasticidad resultante llevará a años de discapacidad y calidad de vida reducida. Se dispone de varios tratamientos para esta condición mórbida, aunque cada uno de ellos está gravado con inconvenientes, incluyendo respuesta clínica incompleta, alto costo, duración limitada de respuesta, efectos colaterales limitantes relacionados a la dosis, y necesidad de mantenimiento periódico. La estimulación medular (EM), alguna vez promisorio tratamiento para la espasticidad, ha sido relegada a un estado experimental permanente.

Métodos.En esta revisión, nuestro objetivo es documentar y criticar la historia y evaluar el desarrollo de SCS como tratamiento de la espasticidad de las extremidades inferiores. Al incorporar los descubrimientos recientes con los conocimientos adquiridos por los primeros pioneros en este campo, tenemos la intención de sentar las bases necesarias para proponer hipótesis comprobables para estudios futuros.

Resultados. La EM ha sido probada en más de 25 condiciones diferentes desde que se reportó un efecto potencialmente beneficioso en 1973. Sin embargo, la falta de una comprensión completa de la fisiopatología de la espasticidad, la metodología de estudio arcaica y las limitaciones tecnológicas iniciales del hardware implantable limitan la validez de muchos estudios. SCS ofrece una medida de control de la espasticidad que no se puede reproducir con otras intervenciones.

Conclusiones. Con una mejor miniaturización de la fuente de energía, algoritmos de control personalizados, un diseño de implantes más desarrollado y una mayor comprensión de la fisiopatología de la espasticidad estamos preparados para reintroducir y volver a probar la EM en esta población.
A rare case of a live abdominal pregnancy in a woman with subsequent gestation in utero
Authors:   Department of Gynecology, Obstetrics and Neonatology of the 1st Faculty of Medicine, Charles University and General Hospital in Prague, Czech Republic, Hájek Zdeněk , Šindlář Milan , Strupplová Jana , Kobilková Jitka
Published: January 2024

This report concerns now 40-year-old healthy woman who was born alive and healthy from an ectopic pregnancy in the abdominal cavity, with placental localization on the omentum. This was a historical case report 40 years ago, as at that time doctors had little information about similar case in the world. Even today, in the era of modern medicine, we find only rare cases where a child developed outside the uterine cavity is born healthy and without developmental deformities. The mother subsequently had a normal intrauterine pregnancy 2 years later, ending with a caesarean section and the birth of a healthy boy. Key words: live abdominal pregnancy – placental localization on the omentum
Preeclampsia and diabetes mellitus
Authors:   Department of Gynecology, Obstetrics and Neonatology of the 1st Faculty of Medicine, Charles University and General Hospital in Prague, Czech Republic, Hornová Markéta , Šimják Patrik , Anderlová Kateřina
Published: January 2024

Objective: The purpose of this paper is to provide a review of recent research on the relationship between preeclampsia and diabetes mellitus in pregnancy. Methodology: A structured search for literary sources in PubMed and ScienceDirect databases using keywords, followed by a selection of papers based on solid methodology. Results: Preeclampsia is a serious condition, which complicates 2–7% of pregnancies. It causes maternal complications (organ dysfunction) and fetal complications (pathological haemodynamic parameters of the uteroplacental unit and fetal growth restriction). Pregnant women with pregestational diabetes have a 2- and 4-times higher risk of developing preeclampsia and the ones with gestational diabetes have 1.3-times higher risk. The main identified risk factors are inadequate compensation of diabetes, diabetic nephropathy, retinopathy and the duration of diabetes. To minimalize the risk of developing preeclampsia, a composite screening has been implemented. With a positive result a preventive use of acetylsalicylic acid from at the latest 16 and up until the 36th week is advised. Preeclampsia is also a risk factor for developing diabetes mellitus and other cardiovascular diseases later in life. For that reason, a long-term dispensary of women who had preeclampsia in pregnancy is recommended. Key words: preeclampsia – proteinuria – pregestational diabetes mellitus – gestational diabetes mellitus – uteroplacental insufficiency – acetylsalicylic acid – late complications of preeclampsia
3D Modelling: A Review
Authors: Ganesh Dnyandev Ghuge
Published: January 2024

Three-dimensional (3D) modeling is a transformative process in the digital realm that involves the creation of virtual representations of objects, environments, or characters. This multifaceted discipline plays a pivotal role across diverse industries, encompassing animation, gaming, virtual reality, architecture, product design, and more. The fundamental components of 3D modeling include vertices, edges, and faces, forming meshes that define the object's geometry. Techniques such as polygonal modeling, NURBS modeling, and subdivision surfaces offer varying approaches to sculpting digital forms. UV mapping ensures precise texture application, while rigging and animation breathe life into models through skeletal structures and movement. The integration of textures, materials, and lighting enhances the realism of rendered images or animations. Computer-Aided Design (CAD) modeling caters to engineering precision, and sculpting tools enable intricate detailing for characters or organic shapes. As technology advances, 3D modeling continues to evolve, influencing the way we visualize, design, and interact with virtual worlds. This abstract provides an overview of key concepts in 3D modeling, highlighting its significance in shaping digital experiences and pushing the boundaries of creative expression and technical innovation.
Az oktatás ereje a menekültek integrációjában
Authors: Sárosi Tünde
Published: January 2024

Az ukrán–orosz háború kitörésekor a budapesti Piarista Gimnázium igazgatója, Horváth Bálint azonnal a menekültek megsegítésének ügye mellé állt és intézményében helyet adott egy olyan segítő programnak, ahol tanárok és önkéntesek közösen szerveztek foglalkozásokat az Ukrajnából Budapestre menekülő gyerekek számára. A kezdeti programok mára egy oktatási központtá nőtték ki magukat, amely az ukrán diákok magyar közoktatásban történő felzárkózását hivatott segíteni. A szervezet munkáját Pavlovski Natasa vezeti és koordinálja. Az ő megindító története a megkülönböztetés nélküli elfogadás fontosságát hangsúlyozza és a szervezet munkája meghatározó jelentőséggel bír az Ukrajnából menekült gyermekek és családok életében. Ebben az írásban arra törekszem, hogy bemutassam miként segíti a szóban forgó projekt az ukrán menekült gyermekeket az iskolai sikerek elérésében, és hogyan próbál közösséget kovácsolni az háborús helyzetben országukból menekülő fiatalokból. A tanulmány célja az, hogy mélyebben megértsük azokat a kihívásokat és problémákat, amelyekkel az adott helyzetben találkozhatunk, és hogy a lehető legátfogóbb képet kapjunk a bevándorló menekültek hétköznapjairól, nehézségeiről és lehetőségeiről.
Bevándorló gyermekek közoktatásbeli integrációja Franciaországban
Authors: Sárosi Tünde
Published: January 2024

A bevándorló gyermekek közoktatásbeli integrációja Franciaországban egy olyan fontos és aktuális kérdés, amely kapcsán a francia oktatási rendszer és társadalom egyaránt kihívásokkal néz szembe. Az elmúlt évtizedekben a migráció folyamatai erőteljesen befolyásolták a franciaországi iskolák demográfiai összetételét, és számos bevándorlócsalád került az országba. A bevándorló gyermekek integrálása a francia oktatási rendszerbe mind nyelvi, kulturális és szociális téren nehézségek elé állítja a folyamat szereplőit. A bevándorlók oktatása nem csupán az oktatási rendszer, hanem az egész társadalom számára kulcsfontosságú kérdés, hiszen hozzájárul a sokszínűség támogatásához és az esélyegyenlőség előmozdításához. A tanulmány célja, hogy mélyebb betekintést nyújtson a bevándorló gyermekek oktatásbeli helyzetébe Franciaországban. Bemutatja az integráció elősegítése érdekében bevezetett politikai intézkedéseket és programokat és elemzi azokat a kezdeményezéseket, gyakorlatokat, amelyek hozzájárulnak a sikeres oktatásban való részvételhez.
SGLT2 inhibitors, intrarenal hypoxia and the diabetic kidney: insights into pathophysiological concepts and current evidence
Authors: Papaetis Georgios S
Published: January 2024

Approximately 20–40% of all diabetic patients experience chronic kidney disease, which is related to higher mortality (cardiovascular and all-cause). A large body of evidence suggests that renal hypoxia is one of the main forces that drives diabetic kidney disease, both in its early and advanced stages. It promotes inflammation, generation of intrarenal collagen, capillary rarefaction and eventually accumulation of extracellular matrix that destroys normal renal architecture. SGLT2 inhibitors are unquestionably a practice-changing drug class and a valuable weapon for patients with type 2 diabetes and chronic kidney disease. They have achieved several beneficial kidney effects after targeting multiple and interrelated signaling pathways, including renal hypoxia, independent of their antihyperglycemic activities. This manuscript discusses the pathophysiological concepts that underly their possible effects on modulating renal hypoxia. It also comprehensively investigates both preclinical and clinical studies that explored the possible role of SGLT2 inhibitors in this setting, so as to achieve long-term renoprotective benefits.
Prevalence of stroke-related risk factors in Albania: a single-center experience
Authors: Mustaqe Petraq , Dimopoulos Platon , Dogjani Agron , Leivaditis Vasileios , Akrida Ioanna , Panagiotopoulos Ioannis , Katinioti Anastasia , Kostopoulou Ira-Eirini , Antzoulas Andreas , Bouchagier Konstantinos , Papadoulas Spyros , Mulita Francesk
Published: January 2024

Introduction

Stroke, a prominent global cause of mortality and disability, is broadly categorized into ischemic and hemorrhagic types. An epidemiological survey of stroke and its risk factors can help identify individuals at higher risk and therefore promote stroke prevention strategies. The aim of this study was to estimate the current prevalence of stroke and evaluate stroke-associated risk factors in Albania.

Material and methods

This was a single-center retrospective analysis conducted in Albania for the period from May 2015 to September 2021. Data were collected retrospectively through hospital records. Stroke was defined as sudden onset of a nonconvulsive and focal neurological deficit, and ischemic stroke was diagnosed using brain computed tomography (CT), magnetic resonance (MR) imaging, or both. We examined patient history characteristics encompassing demographics, stroke history, conventional vascular risk factors, and lifestyle-related risk factors.

Results

The mean age of the 3860 patients was 74.6 ±10.4 years, and 73.5% were men. The prevalence of carotid stenosis, arrhythmia, obesity, and hypertension was significantly higher in males than in females (p < 0.001). Out of the 3860 patients in the study cohort, 641 (16.6%) subjects died, while 335 (8.7%) patients achieved complete recovery. Hemiparesis was observed in 386 (10%) patients and hemiplegia in 868 (22.4%) patients.

Conclusions

Our analysis underscores the male predominance (2.2 : 1) in stroke cases. Carotid and vertebral artery stenosis is a significant factor, emphasizing the life-saving potential of early intervention. Social and economic factors in Albania pose challenges, demanding comprehensive strategies. Prospective trials are crucial to explore intervention efficacy, and timing, and address socioeconomic impacts on timely stroke management.
Developing a Multidimensional Fuzzy Deep Learning for Cancer Classification using Gene Expression Data
Authors: Khalsan Mahmood , Mu Mu , Al-shamery Eman Salih , Ajit Suraj , Machado Lee , Agyeman Michael Opoku
Published: January 2024

In the realm of cancer research, the identification of biomarker genes plays a pivotal role in accurate classification and diagnosis. This study delves into the intersection of machine learning and gene selection to enhance the precision of biomarker identification for cancer classification. Leveraging advanced computational techniques. In the quest for improved cancer classification, studies face challenges due to high-dimensional gene expression data and limited gene relevance. To address these challenges, we developed a novel multidimensional fuzzy deep learning (MFDL) to select subset of significant genes and using those genes to train the model for better accuracy. MFDL is exploring the integration of fuzzy concepts within filter and wrapper methods to select significant genes and applying a fuzzy classifier to improve cancer classification accuracy. Through rigorous experimentation and validation, six gene expression data used, the findings demonstrated the efficacy of our methodology on diverse cancer datasets. The results underscore the importance of integrative computational methods in deciphering the intricate genomic landscape of cancer and spotlight the potential for improved diagnostic accuracy. The developed model showcased outstanding performance across the six employed datasets, demonstrating an average accuracy of 98%, precision of 98.3%, recall of 97.6%, and an f1-score of 97.8%.
Deep Learning based Zero Watermarking for Authentication of Medical Records
Authors: Kaur Gurleen , Gupta Bakul , Anand Ashima
Published: January 2024

The security of digital images is crucial since they often contain sensitive and confidential data. Unauthorized access to this data could result in severe penalties for the parties involved. Despite the availability of highly secure algorithms, security remains a significant concern due to the rapid emergence of new technologies that can breach it. Thus the proposed work implements a technique that makes the confidential data inaccessible to intruders. Hence fragile type of data hiding technique is used where even with the slightest tampering to the image by an attacker, the information i.e. watermark image is completely destroyed, hence preventing it from unauthorized access. Also, a hybrid transform including DTCWT and NSST is used to fuse two medical images to form a more sophisticated output image, which serves as the final watermark. Further, the zero watermarking model is implemented using the ResNet 50 DL model for more precise results and extraction of feature maps. Embedding the actual image in the carrier image could make the watermarking detectable especially when it is fragile, hence Zero Watermarking overcomes this also by virtual embedding. Moreover, the algorithm employs the avalanche effect of SHA512 for highly secure authentication, further strengthening the security of the system. Overall, the proposed method is an effective way to ensure the security of digital images with confidential data.
G-KMM: A Flexible Kernel Mean Matching Optimization Method for Density Ratio Estimation Involving Multiple Train & Test Datasets
Authors: Alecsa Cristian Daniel
Published: January 2024

In the present paper we introduce new optimization algorithms for the task of density ratio estimation. More precisely, we consider extending the well-known KMM (kernel mean matching) method using the construction of a suitable loss function, in order to encompass more general situations involving the estimation of density ratio with respect to subsets of the training data and test data, respectively. The codes associated to our Python implementation can be found at https://github.com/CDAlecsa/ Generalized-KMM.
El método de la participación: impacto en los estados financieros y retos actuales que supone para las empresas
Authors: García Puente Alejandro
Published: January 2024

El método de la participación o procedimiento de puesta en equivalencia es un tratamiento contable ampliamente extendido en los estados financieros consolidados de la mayoría de los grupos empresariales. Su debut hace décadas justifica que esté sobradamente integrado en los procesos contables de las entidades, pero la evolución de los mercados y las operaciones financieras cada vez más complejas han hecho que se planteen dudas sobre la aplicación de este tratamiento. Esta falta de regulación en la norma contable deriva en que muchas entidades apliquen criterios distintos ante una misma operación, lo que dificulta la comparabilidad requerida por el marco conceptual. Este problema se agrava si se considera que, de media, un 8,15 % del resultado neto de las empresas del IBEX 35 viene explicado por los resultados de las inversiones sobre las que se aplica el método de la participación, por lo que tiene un impacto razonablemente significativo. Ante esta tesitura, el regulador contable internacional (IASB) está trabajando en un proyecto de modificación de norma para detectar y abordar los problemas que se están planteando. Algunas de las decisiones tomadas hasta el momento se han encaminado a incrementar la divergencia entre la normativa local española y la internacional, mientras que otras han estrechado esta brecha. A lo largo del estudio se analizan las cuestiones de aplicación más relevantes, así como la comparativa con el marco normativo local.
Con todo, está claro que la contabilidad no es perfecta, pero sí dinámica, resiliente y, sin duda, la mejor herramienta que tenemos para evaluar el rendimiento de las empresas.
Vinculación de la Administración tributaria y de la jurisdicción contenciosa a los hechos fijados en sede penal: ¿la jurisdicción penal es prevalente respecto de otros órdenes?
Authors: García Díez Claudio
Published: January 2024

El presente comentario se centra en las relaciones entre jurisdicciones a la hora de entender acreditados unos mismos hechos. Más concretamente, si hay una jurisdicción prevalente respecto a otras. En particular, si el orden penal, al declarar indubitadamente un hecho probado (dotado de trascendencia incriminatoria o absolutoria), debe ser acatado sin reservas por otros sectores del ordenamiento o, por el contrario, se deja la puerta abierta a la posibilidad de aceptar relatos fácticos contradictorios en función del ámbito (penal, civil, contencioso, etc.) ante el que nos encontremos.
METHODS OF APPLYING THE ENVIRONMENTAL APPROACH IN ARCHITECTURAL DESIGN IN MODERN RESIDENTIAL COMPLEXES
Authors:   S. Seifullin Kazakh AgroTechnical University, Baidrakhmanova M.G. , Kornilova A.A. ,   S. Seifullin Kazakh AgroTechnical University, Aldungarova A.K. ,   D. Serikbayev East Kazakhstan technical university, Kulisz Monika ,   Lublin University of Technology
Published: January 2024

The purpose of this work is the design of the environment and landscapes associated with human life, requires, on the one hand, taking into account the values and potential of the environment, and on the other hand, taking into account human needs. This design of the environment must be persistently pursued through interaction and balance with the environment. The purpose of this study was to propose strategies for applying an ecological approach to architectural design in modern residential complexes. The research method is descriptive-analytical and applied. Performing this study, both field and documentary methods, data were collected, analyzed and integrated. In order to highlight Weakness and internal weakness, as well as external opportunities and threats, we used the SWOT analysis model, identifying the most preferred design strategies, as well as integrating the landscapes of the external and internal environment using the QSPM matrix. The results showed that the most preferred strategy for designing open areas and landscapes with an ecological vision and improving visual quality is the approach of spatial and visual continuation with the internal atmosphere of residential complexes. Today it has become obvious that in large cities of the Earth the natural component of the environment is noticeably reduced and a particularly topical issue, for the past decades, is the appeal of the world architectural community to the environmental aspects of design and construction, contributing to the comfortable, sustainable development of urban space favorable social and environmental logical microclimate of the architectural environment.
RADIATION PROTECTION IN THE NUCLEAR MEDICINE CENTER FROM PET RADIONUCLIDE
Authors:   Civil Aviation Academy, Lutsenko N.S. , Kim D.S. ,   Civil Aviation Academy, Zhumagulova R.E. ,   International Educational Corporation, Zharaspaeva G.Z. ,   International Educational Corporation, Zhandildinova K.M. ,   Civil Aviation Academy
Published: January 2024

The purpose of this article is to present a methodology for determining sufficiency of the wall thickness to protect patients from the non-therapeutic effects of a medical source of ionizing radiation and calculating its increase in a way alternative to the use of the Monte Carlo method. The article is based on a case with a specific source of 18F activity of 4 Сi in a tungsten container with a wall thickness of 29.5 mm, which are used in the Center of Nuclear Medicine of the Republic of Kazakhstan. The objectives of the study are the following: calculation of the exposure dose rate from a radionuclide source of certain activity; calculation of the multiplicity of the dose attenuation rate to ensure human safety and establishing the necessary thickness of protection from the opted building material. The results of these calculations may differ depending on the method of direct and reverse recalculation of various radiation doses units, and therefore the conclusion suggests the most optimal of them in terms of physical efficiency, economic feasibility and regulatory performance. Operational dosimetry solves the problem of implementing the ALARA principle, problems of optimizing radiation safety are solved. Reducing the dose load on a person is achieved by reducing the operating time, increasing the distance to the radiation source and using a protective screen. The article describes the choice of protective material and its thickness for protection against radionuclide sources.
INFLUENCE OF PLASTICIZING AND AIR-ENTRAINING ADMIXTURES ON CONCRETE PROPERTIES
Authors:   Satbayev University, Tolegenova A.K. , Akmalaiuly K. ,   Satbayev University, Yespayeva A. ,   Satbayev University, Altayeva Z. ,   International Educational Corporation, Kuldeyev E. ,   Satbayev University
Published: January 2024

In the modern construction industry of Kazakhstan, to ensure the needs of the market, there is an urgent essential to improve the quality of concrete and expand its functional purpose. To a large extent, this is achieved by designing concrete as composite materials with different structures, quantities and nature of components. The multicomponent composition makes it possible to effectively manage the structure formation processes of the concrete cementing matrix and obtain concretes with the required properties. This article presented the effect of plasticizing and air-entraining admixtures on the properties of heavy concrete. The compositions of concrete mixture with plasticizing and air-entraining admixtures were selected. The results of study of plasticizing and air-entraining admixtures effect on average density, workability, compressive strength of concrete samples are presented. The effectiveness of introduction of a complex admixtures was evaluated in order to further improve operational properties of concrete. The plasticizing effect makes it possible to increase workability of concrete mortar while by reducing water-cement ratio from 0,5 to 0,38. Due to this, density and strength of concrete increased while improving operational characteristics. The combined effect of plasticizing and air-entraining admixtures had a positive effect on mobility of concrete mortar and its strength of concrete samples. The significant strength of 47,2 MPa was achieved with the combined introduction of a plasticizing and air-entraining admixtures in the amount of 1,2% and 0,5% of the cement weight, thereby increasing the strength of concrete samples by 32% compared to the control sample.
Kriz İletişiminde Sosyal Medya Yönetimi: United Aırlines Overbooking Kriz Analizi1
Authors: IŞIK Muhammet Efe , TATLI Erdem
Published: January 2024

Bu çalışmada sosyal medyada kriz yönetimi konusu, dünyanın öncü havayolu şirketlerinden United Airlines’ın 2017 yılında yaşadığı Overbooking Krizi üzerinden kapsamlı bir şekilde ele alınmaktadır. Araştırma neticesinde firmaların sosyal medya yönetimlerine, müşteri deneyimi ve şikayetlerine, sosyal medya stratejilerine ve iletişim planlamalarına önem vermemeleri durumunda yaşayacakları krizler, ilgili örnekler üzerinden açık bir şekilde gösterilmektedir. Çalışmada kurumların maruz kaldığı krizlerden sonra kurum itibarı ve imajında yaşanan olumsuz durumlar, krizlerin ardından yaşanılan ekonomik kayıplar, sosyal medyanın kriz oluşumunda edindiği rol ve yara alan kurum imajının düzeltilmesinde yapılması gerekenlerin ortaya koyulması amaçlanmaktadır. Çalışmada ele alınan örnekler İmaj Restorasyon Teorisi bağlamında incelenmiştir. Çalışmada doğru ve etkili sosyal medya yönetiminin, şirketlerin finansal ve itibar yönetimleri açısından kritik bir öneme sahip olduğu sonucuna varılmış; sosyal medya üzerinden gerçekleştirilen itibar yönetiminde CEO ve üst düzey firma çalışanlarının tutumlarının önemi ortaya konulmuştur.
ANALGESIC ACTIVITY OF COMPLEX OF O-BENZOYLOXIME OF 3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE WITH -CYCLODEXTRIN
Authors:   Korkyt ata Kyzylorda University, Togyzbaeva N.A. , Sikhanova N.S. ,   Korkyt ata Kyzylorda University, Kaldybayeva A.B. ,   A.B. Bekturov Institute of Chemical Sciences; Al-Farabi Kazakh National University, Malmakova A.E. ,   A.B. Bekturov Institute of Chemical Sciences
Published: January 2024

Pain syndrome is the most common phenomenon in medical practice. Despite the variety of drugs availability, the search for new highly effective analgesics for pain management remains the most important goal. The purpose of the work: directed synthesis of potential biological active diazabicyclononanone series compounds based on 1-(2-ethoxyethyl)piperidin-4-one, modifying the structure of diazabicyclononanone with various pharmacophore functional groups and determining their biological properties. Results and discussions: 3-(2-Ethoxyethyl)-7-cyclopropanemethyl-3,7-diazabicyclo[3.3.1]nonan-9-one have been synthesized by Mannich reaction of 1-(2-ethoxyethyl)piperidin-4-one with the primary amine 3-cyclopropylmethylamine and paraform in glacial acetic acid and methanol. In order to obtain a compound with pharmacological activity 3,7-diazabicyclononanone have been obtained out by the Huang-Minlon reduction reaction, and as a result, 3-(2-ethoxyethyl)-7-cyclopropanemethyl-3,7-diazabicyclo[3.3.1]nonane was isolated with a yield of 74.2 %. Oxymylation of 3,7-diazabicyclononanone was carried out by heating in the presence of pyridine and hydroxylamine hydrochloride in ethyl alcohol for 20-25 h. Synthesised oxime after heating with benzoyl chloride in the presence of absolute benzene for 6-7 h led to O-benzoyloxime. Encapsulation of O-benzoyloxime was resolved using b-cyclodextrin. As a result, an amorphous powder complex was obtained. Structure and composition of newly synthesized 3-(2-ethoxyethyl)-7-cyclopropanemethyl-3,7-diazabicyclo[3.3.1]nonan-9-one, bispidine, oxime and O-benzoyloxime clarified with the help of methods as IR, 13C and 1H NMR spectroscopy and elemental analysis. Conclusion: Biological activity of complex of O-benzoyloxime of 3-(2-ethoxyethyl)-7-cyclopropylmethyl-3,7-diazabicyclo[3.3.1]nonan-9-one with b-cyclodextrin with laboratory code NA-332 has been studied at the Institute of General Genetics and Cytology. As a result of biological screening, it was found that the complex of O-benzoyloxime of 3-(2-ethoxyethyl)-7-cyclopropylmethyl-3,7-diazabicyclo[3.3.1]nonan-9-one with b-cyclodextrin shows higher analgesic activity than tramal and has complete analgesia. The results of studies determine the acute toxicity of HA-332 lower than tramal.
FEATURES OF EXTRACTION OF LUTETIUM AND SCANDIUM IONS BY THE INTERPOLYMER SYSTEMS LEWATIT CNP LF-AB-17-8
Authors:   A.B. Bekturov Institute of Chemical Sciences JSC, Jumadilov Т.К. , Khimersen Kh. ,   A.B. Bekturov Institute of Chemical Sciences JSC; Abai Kazakh National  Pedagogical University, Haponiuk J. ,   Abai Kazakh National  Pedagogical University
Published: January 2024

Interpolymer systems based on ion exchange resins Lewatit CNP LF and AB-17-8were used to separate metal ions from sample solutions containing lutetium and scandium.The researchaimsto achieve maximum absorption of lutetium and scandium ions by using the remote interaction effect of macromolecular polymers.Methodology.Jenway-6305 spectrophotometer (SK) was used to determine the residual concentration of metal ions in the solution.The obtained resultsshow that individual polymers Lewatit(6:0) and AB-17-8 (0:6) do not have a higher absorption of lutetium ions (24.96% and 21.13%, respectively) rather than interpolymer systems. The maximum degree of extraction of lutetium ions is observed at a ratio of 4:2.The maximum values of the degree of absorption of scandium ions are observed at ratios of 5:1 and 1:5.As a result of the conducted studies, it was found that with an increase in the amount of one polymer in the interpolymer pair, the degree of binding of the second polymer to the metal ion increases. The LewatitCNP LFcation exchanger has a binding degree of 2.99 mg/mol in a ratio of 6:0, and with an increase in the amount of anion exchanger AB-17-8 by 5times, the binding degree of the cation exchanger in a ratio of 1:5 has increased to13.84 mg/mol. The binding degree of AB-17-8 in the ratio of 0:6 increased from 2.03 mg/mol to 12.20 mg/mol witharatio of interpolymer systems of 5:1.The degree of binding of the cation exchanger with the lutetium ion increased by 4.5 times, and the degree of binding of the anion exchanger increased by 6times.Conclusion.The results obtained show the possibility of using interpolymer systems for the extraction of lutetium and scandium ions from industrial aqueous solutions.
A REVIEW OF DATA-DRIVEN BUSINESS OPTIMIZATION STRATEGIES IN THE U.S. ECONOMY
Authors: Odunayo Josephine Akindote  , Zainab Efe Egieya  , Sarah Kuzankah Ewuga  , Adedolapo Omotosho  , Abimbola Oluwatoyin Adegbite
Published: January 2024

This research explores the landscape of data-driven business optimization in the U.S. economy, analyzing key components, benefits, challenges, and future trends. The study emphasizes the importance of effective data collection, advanced analytics, and informed decision-making. Regulatory compliance, ethical considerations, and integrating technology and infrastructure are essential elements shaping the journey toward optimization. Despite notable benefits such as improved efficiency and enhanced customer experiences, organizations face data quality, privacy, and cultural shift challenges. Future trends indicate the integration of AI, real-time analytics, and blockchain, pointing towards a dynamic future. As organizations navigate this evolving landscape, the quest for data-driven optimization emerges as a continuous and transformative journey.

Keywords: Data-Driven Optimization, Business Analytics, Decision-Making, Regulatory Compliance.
Abu Hamid al-Ghazali in Our Times: How al-Ghazali is Interpreted and Transmitted in the Contemporary Turkish Context
Authors: Bacik Gokhan
Published: January 2024

Whether Abu Hamid al-Ghazali contributed to the decline of rationalist and scientific tradition in the Muslim world is a grand debate in Islamic studies. However, the literature on this question ventures only to construct a historical debate. Though al-Ghazali died in 1111, his opinions still influence Muslims today. So this research, rather than contribute to that historical debate, studies how al-Ghazali is interpreted in contemporary Turkey, and what this inter­pretation reveals about approaches to natural law, knowledge and philosophy (essentially, the study of conceptual lucidity and the valid procedures of reaso­ning). These three disciplines are chosen because al-Ghazali is accused of contributing to the decline of the scientific tradition in the Islamic world beca­use of his criticism of philosophy, his occasionalist view of causality, and his incorporation of inner knowledge into Sunnism. The research aims to answer ques­tions like: ‘Are al-Ghazali’s works referenced today to justify a hostile stance on philosophy?’ To achieve this goal, the research studies how al-Ghazali is interpreted by two Islamic social movements in Turkey: Işıkçılar and Erenköy. Studying these cases, the paper concludes that how al-Ghazali is interpreted and transmitted in Turkey contributes to (i) a highly sceptical stance on natural law, (ii) a deep suspicion of rational knowledge and the consequent belief in inner knowledge, and (iii) a highly critical stance on philosophy.
Penerapan Metode Computer Assisted Instruction (CAI) Pada Media Pembelajaran Interaktif Fashion Drawing dengan pada Kelas X Kompetensi Keahlian Busana Butik SMK NU 01 Kendal
Authors: Prihatmoko Setiyo , Sumaryanto Sumaryanto , Anja Robbi Dini
Published: January 2024

Berdasarkan penelitian yang dilakukan di SMK NU 01 Kendal khususnya pada pembelajaran menggambar busana di kelas X busana butik masih menggunakan pembelajaran konvensional dengan media papan tulis, media pembelajaran tersebut kurang efektif karena memerlukan banyak tenaga dan waktu untuk materi pembelajaran yang banyak memuat gambar. dan tutorial yang perlu disampaikan berulang kali. Penelitian ini menemukan solusinya yaitu dengan merancang media pembelajaran dengan menggunakan metode Computer Assisted instruction (CAI), suatu sistem penyampaian pembelajaran berbasis multimedia interaktif dengan materi pembelajaran disajikan melalui komputer atau sistem komputer, sehingga dapat membantu guru menyampaikan materi dengan efektif, dan membuat siswa belajar dengan motivasi tinggi karena tertarik dengan sistem multimedia yang mampu menyajikan tampilan teks, gambar, video, suara dan animasi. Nilai validasi ahli media menunjukkan nilai 3,1 tergolong baik/valid, dan hasil validasi ahli materi menunjukkan nilai 3,5 termasuk kategori sangat baik/sangat valid, dan terjadi peningkatan nilai persentase keefektifan. dari 50,4% menjadi 81,7%. serta adanya efisiensi waktu, salah satu material seperti gambar kerah dapat menghemat waktu hingga 18 menit.
On the use of routine airborne observations for evaluation and monitoring of satellite observations of thermodynamic profiles
Authors: Wagner Timothy J. , August Thomas , Hultberg Tim , Petersen Ralph A.
Published: January 2024

Abstract. Satellite-based observations require independent sources of data to monitor and evaluate their precision and accuracy. For the temperature and water vapor profiles produced by satellite-based sounders, this typically results in comparisons to operational radiosonde observations. However, polar-orbiting satellite overpasses are frequently misaligned with the global synoptic launch times. The routine airborne in situ observations of temperature and water vapor from the Airborne Meteorological Data Relay (AMDAR) program and the Water Vapor Sensing System-II (WVSS-II) instrument greatly enhance opportunities to make precise matchups due to the far greater temporal frequency and spatial density of aircraft flights. The potential for the use of aircraft-based observations as a source of evaluation of tropospheric satellite sounder profiles is explored through a year-long intercomparison with the Infrared Atmospheric Sounding Interferometer (IASI) level-2 profiles produced from both the Metop-A and Metop-B satellites. Results using 1 h and 50 km match criteria indicating good agreement between the satellites and the aircraft-based observations with temperature, specific humidity, and relative humidity biases generally less than 0.5 K, 0.8 g kg−1, and 5 %, respectively; both IASI instruments perform nearly identically. While the intercomparisons are generally limited to the troposphere as aircraft typically reach their maximum height at the tropopause, the substantially larger number of intercomparison points enable characterization as a function of season, scan angle, and other characteristics heretofore unexplored due to a lack of sufficient validation data.
Visual simultaneous localization and mapping (vSLAM) algorithm based on improved Vision Transformer semantic segmentation in dynamic scenes
Authors: Chen Mengyuan , Guo Hangrong , Qian Runbang , Gong Guangqiang , Cheng Hao
Published: January 2024

Abstract. Identifying dynamic objects in dynamic scenes remains a challenge for traditional simultaneous localization and mapping (SLAM) algorithms. Additionally, these algorithms are not able to adequately inpaint the culling regions that result from excluding dynamic objects. In light of these challenges, this study proposes a novel visual SLAM (vSLAM) algorithm based on improved Vision Transformer semantic segmentation in dynamic scenes (VTD-SLAM), which leverages an improved Vision Transformer semantic segmentation technique to address these limitations. Specifically, VTD-SLAM utilizes a residual dual-pyramid backbone network to extract dynamic object region features and a multiclass feature transformer segmentation module to enhance the pixel weight of potential dynamic objects and to improve global semantic information for precise identification of potential dynamic objects. The method of multi-view geometry is applied to judge and remove the dynamic objects. Meanwhile, according to static information in the adjacent frames, the optimal nearest-neighbor pixel-matching method is applied to restore the static background, where the feature points are extracted for pose estimation. With validation in the public dataset TUM (The Entrepreneurial University Dataset) and real scenarios, the experimental results show that the root-mean-square error of the algorithm is reduced by 17.1 % compared with dynamic SLAM (DynaSLAM), which shows better map composition capability.
Evaluation of reanalysis data and dynamical downscaling for surface energy balance modeling at mountain glaciers in western Canada
Authors: Draeger Christina , Radić Valentina , White Rachel H. , Tessema Mekdes Ayalew
Published: January 2024

Abstract. Regional-scale surface energy balance (SEB) models of glacier melt require forcing by coarse-gridded data from reanalysis or global climate models that need to be downscaled to glacier scale. As on-glacier meteorological observations are rare, it generally remains unknown how exact the reanalysis and downscaled data are for local-scale SEB modeling. We address this question by evaluating the performance of reanalysis from the European Centre for Medium-Range Weather Forecasts (ERA5 and ERA5-Land reanalysis), with and without downscaling, at four glaciers in western Canada with available on-glacier meteorological measurements collected over different summer seasons. We dynamically downscale ERA5 with the Weather Research and Forecasting (WRF) model at 3.3 and 1.1 km grid spacing. We find that our SEB model, forced separately with the observations and the two reanalyses, yields less than 10 % difference in simulated total melt energy and shows strong correlations (0.86) in simulated time series of daily melt energy at each site. The good performance of the reanalysis-derived melt energy is partly due to cancellation of biases between overestimated incoming shortwave radiation and substantially underestimated wind speed and subsequently turbulent heat fluxes. Downscaling with WRF improves the simulation of wind speed, while other meteorological variables show similar performance to ERA5 without downscaling. The choice of WRF physics parameterization schemes is shown to have a relatively large impact on the simulations of SEB components but a smaller impact on the modeled total melt energy. The results increase our confidence in dynamical downscaling with WRF for long-term glacier melt modeling in this region.
From Upstream to Downstream: Islam and the State Preventing LGBT
Authors: Tsalis Khodijah Nur , Ali Mardhatillah , Surahman Surahman
Published: January 2024

The state has a constitution and Islam has a sharia that aims to regulate human life so that it runs well and does not violate the eastern norms and values adopted by Indonesian society. This article aims to examine the extent of the state's efforts through the Constitution and Islam through sharia to prevent someone from becoming LGBT. This research is a literature review with the type of normative research that uses the statute approach and phenomenological approach. Based on the analysis, the state and Islam have tried to prevent LGBT early on. The Constitution and Sharia regulate that the family is formed on a good and solid foundation in the face of LGBT issues. However, due to the lack of firmness of the Constitution, LGBT perpetrators still find loopholes to exist and change their appearance to better match the gender they want. At the end of the stage, to legalize the gender transition and be recognized by the state, they apply for a change of identity on the Indonesia Identity card through the Court. The constitution that regulates this change is also considered not firm, all returned to the judgment and decision of the judge to accept or reject their application.
Uncovering the potential of Twitch as a source for social media metrics
Authors: Orduña-Malea Enrique , Lopezosa Carlos
Published: January 2024

The social live streaming service Twitch was launched in 2008 as Justin.tv, rebranded as Twitch Interactive in 2011, and acquired by Amazon in 2014. Although launched originally as a portal to broadcast videogames, Twitch currently hosts a wide range of content, including science and technology channels. Yet, despite growing interest in this online video sharing platform, Twitch’s potential for the study of science videos has been underexploited to date. This paper seeks to go some way to remedying this by studying the potential of Twitch as a data source for social media academic metrics. To do so, a scientometrics-inspired framework (the OBA framework) is proposed to integrate the analysis of Twitch, science videos and research organizations under a common conceptual space. Then, a science-related Twitch channel — National Aeronautics and Space Administration (NASA) — is used as a case study. We analyse 197 videos published by NASA between March 2017 and December 2022, as well as 51,935 clips created from NASA videos. Data were collected from the official Twitch API, which is also analysed to identify the units and metrics available and the channel’s performance in retrospective quantitative studies (i.e., non-live broadcasts). The results show that Twitch allows in-depth metric analyses of science videos to be undertaken, facilitating identification of both the activity and output-level impact of a scientific organization such as NASA. However, the Twitch API presents a few constraints, due, in the main, to the limited availability of many metrics that are restricted in time range, quantity, accuracy, or access, and which as such limit comprehensive retrospective studies. Despite these technical limitations, it is estimated that Twitch offers considerable potential for the study of science-related activity. The OBA model proposed facilitates the analysis of the activity of specific scientific agents (not only organizations but journals or other aggregates) under a conceptual framework based on approaches applied in quantitative studies of science.
Studying digital disconnection: A mapping review of empirical contributions to disconnection studies
Authors: Altmaier Nina , Kratel Victoria A. E. , Borchers Nils S. , Zurstiege Guido
Published: January 2024

As digital connectivity continues to shape society, scholarly discourses have paid increasing attention to our desires to moderate our use of, or disconnection from, digital media. Digital disconnection is being studied from a plethora of different perspectives, all of which grapple with the challenge of understanding and studying how digital media users navigate pressures to disconnect and remain connected at the same time. We contribute to the growing literature on digital disconnection by taking stock of empirical studies on the topic through a mapping review. Drawing on 138 peer-reviewed articles, we report the different kinds of disconnection behaviors studied, the users sampled, and the methods used. Our findings indicate that, while there are various calls for the greater incorporation of intersectional and socioeconomically diverse perspectives on disconnection studies, thus far these facets remain comparatively under-researched. We also find two key methodological tendencies, one toward one-time data generation via interviews and surveys, the other toward studies that rely on participants’ temporary disconnection.
PENGARUH DUKUNGAN ORGANISASI DAN KOMITMEN ORGANISASI TERHADAP KINERJA KARYAWAN
Authors: Retnowati Eli , Masnawati Eli
Published: January 2024

Studi ini bermaksud untuk menganalisis pengaruhnya Perceived Organizational Support (POS) dan Komitmen Organisasi terhadap kinerja karyawan di suatu perusahaan manufaktur di Kota Surabaya. POS mencerminkan pandangan subjektif karyawan tentang sejauh mana organisasi memiliki kepedulian terhadap kebutuhan dan kesejahteraan karyawannya, sementara komitmen organisasi mencakup tingkat keterikatan dan identifikasi karyawan dengan nilai-nilai dan tujuan organisasi. Di studi ini, data dikumpulkan melalui survei, wawancara, dan analisis dokumentasi, dan dianalisis menggunakan regresi linier berganda. Hasil studi mengindikasikan bahwa kombinasi POS dan komitmen organisasi memiliki pengaruh signifikan terhadap kinerja karyawan. Karyawan yang merasa didukung dan terlibat secara aktif di misi organisasi cenderung memperlihatkan kinerja yang lebih positif, motivasi untuk berinovasi, dan tingkat retensi yang tinggi. Temuan ini memperkuat konsep bahwa dukungan organisasi dan komitmen organisasi memainkan peran krusial untuk membentuk hubungan positif antara karyawan dan organisasi, serta berdampak pada efektivitas dan keberlanjutan kinerja individu.
HUBUNGAN PENDIDIKAN DAN UMUR IBU DENGAN KEPATUHAN KUNJUNGAN ANC DI PMB TAHUN 2023
Authors: Satra Yunola  , Siti Amallia
Published: January 2024

Antenatal Care (ANC) merupakan suatu pelayanan yang diberikan oleh perawat kepada wanita selama hamil misalnya dengan pemantauan kesehatan secara fisik psikologis, termasuk dan perkembangan janin serta mempersiapkan proses persalinan dan kelahiran supaya ibu siap menghadapi peran baru sebagai orang tua. Penilaian terhadap pelaksanaan pelayanan kesehatan ibuhamil dapat dilakukan dengan melihat cakupan K1, K4, dan K6. Tujuan penelitian ini adalah Diketahui Hubungan Pendidikan dan Umur Ibu Dengan Kepatuhan Kunjungan ANC di PMB Tahun 2023. Jenis penelitian ini bersifat metode survey analitik dengan menggunakan pendekatan cross sectional. Sampel dalam penelitian ini Sampel dalam penelitian ini sebanyak 73 responden. Pengumpulan data dalam penelitian ini menggunakan data sekunder di PMB tahun 2023 dengan melihat dan mencatat rekam medik pada lembar Check list. Hasil penelitian bivariat Hubungan Pendidikan dan usia ibu dengan Kepatuhan Kunjungan ANC p value < 0,05 (pendidikan 0,025) dan (usia ibu 0,026) terdapat hubungan yang signifikan antara pendidikan dan usia ibu dengan Kepatuhan Kunjungan ANC.