bluuebunny/crossref_metadata_2025 huggingface dataset:
Questions to the Article: Exploring the Shift in International Trends in Mobile Health Research From 2000 to 2020 (Preprint)
Authors: Lin Ju-Kuo , Chien Tsair-wei , Chou Willy
Published: November 2021

UNSTRUCTURED

The article published on September 9, 2021, is well-written and of interest, but remains two questions that are required for clarifications, such as the ways (1) to construct the growth curve and (2) to determine the flashpoint(or, say, inflection point, IP) on the growth curve shown in Figure 3. The authors addressed that the year 2015 was a flashpoint on the curve(ie. y = 37e0.3062x, with R2=0.9935) and determined the flash point by the naked eye. Although numerous bibliometric analyses applied the cumulative publications to release information about the growth curve and the IP using a particular formula, none of such research proposed an appropriate way to determine the IP. Accordingly, we are motivated to propose an item response theory (IRT) model(IRT) to determine the IP on a given ogive curve and found that the IP is in 2017 instead of 2015 with R2=0.9797 rather than 0.9935 in the questionable article. Similarly, the real model coefficient and R2 are 0.2942 and 0.9954, respectively, if the growth curve is modeled by the formula(= 37ebx ) in Microsoft Excel using the Solver add-in tool demonstrated in this article. The ITR model used to determine the IP location on cumulative time-series data is recommended to future relevant studies, not merely limited to the bibliometric analysis.
HYPERTENSION IN RELATION TO IMMUNE SYSTEM AND WAY OF LIFE ALONG WITH TREATMENT
Authors: MEHRA RAHUL , AANCHAL  , KALSI SHAINA , GAUTAM SURYA P.
Published: November 2021

The objective of the review is to explain the pathophysiology, different causes and various treatments involved in hypertension. This article discusses the disease's pathogenesis, etiology, diagnosis, and immunity. This review looks at the main significant epidemiological and clinical studies on the role of several lifestyle factors in hypertension development. This review examines the numerous mechanisms that cause hypertension in order to discover new treatments. In addition, it covers the many types of hypertension therapy. According to different studies, lifestyle habits may have an impact on blood pressure levels.

Moreover, the importance of chronic inflammation in hypertension and its repercussions has been confirmed in genetically engineered mice lacking components of innate and/or adaptive immunity. Immune cell depletion enhances endothelial function, lowers oxidative stress, lowers the vascular tone, and protects against renal interstitial infiltrates, salt retention, and kidney injury. Based on existing literature, there is strong evidence that lifestyle variables can affect blood pressure levels. Then, in hypertensive people, lifestyle changes can help by lowering overall cardiovascular risk and death from any cause. The involvement of immunity as a common thread in the hypertension processes of many organ systems.
DOSE-DEPENDENT PROTECTIVE FEATURES OF LOBOPHORA VARIEGATA METHANOLIC EXTRACT (LVME) IN N-NITROSODIETHYLAMINE INDUCED EXPERIMENTAL HEPATOCARCINOGENESIS IN RATS
Authors: AJITHA ADAIKKALAM , SUBRAMANIAN PERUMAL
Published: November 2021

Objective: This study explores the anti-cancer property of Lobophora variegata, also an effective dose to treat hepatocarcinoma in Male Albino Wistar rats in N-nitrosodiethylamine induced hepatocarcinoma paradigm and its possible mechanism of action.

Methods: In this study, rats were segregated into five groups; group-1 (control), group-2 treated with 0.01% NDEA through drinking water for 15 w, group-3 NDEA+treated with Lobophora variegata methanolic extract (LVME) (100 mg/kg b.w.), group-4 NDEA+treated with (LVME) (200 mg/kg b.w.) and group-5 NDEA+treated with (LVME) (400 mg/kg b.w.).

Results: After the experimental period, functional and morphological changes in the liver were observed both macro and microscopically, the activities of liver marker enzymes, alkaline phosphatase (ALP), aspartate and alanine transaminases (AST and ALT) were analyzed. Administration of LVME as 200 mg/kg b.w. (to NDEA treated rats) significantly (i) reduced the preneoplastic lesions alleviated lipid peroxidation through scavenging free radicals, (ii) enhanced antioxidant status and reverted liver/disease marker enzymes plausibly by modulating xenobiotics metabolizing enzymes (XMEs) and by exhibiting antiproliferative and cytoprotective effects.

Conclusion: LVME doses higher than 200 mg/kg b.w. are not effective in quenching the free radicals and restoring the liver functions as saturation level could have been reached; also, doses lower than 200 mg/kg b.w. could not be effective as they are below the optimum dose required to exhibit the pharmacological effects.
ТРЕБОВАНИЯ К ФИЗИЧЕСКОЙ ВЕРИФИКАЦИИ СНК В УСЛОВИЯХ ПЕРЕХОДА НА СУБНАНОМЕТРОВЫЕ ТЕХНОЛОГИЧЕСКИЕ НОРМЫ (МЕНЕЕ 16 НМ)
Authors: Саутер Г.
Published: November 2021

Представлен обзор методов физической верификации СнК, актуальность которых вызвана применением субнанометровых технологических норм. Показано как обозначенная проблематика решается средствами автоматизации предпроизводственных проверок применительно к модели fabless и TSMC как производственной площадке.
НАТИВНАЯ ТЕХНОЛОГИЧЕСКАЯ ПЛАТФОРМА ДЛЯ ФИЗИЧЕСКОГО ПРОЕКТИРОВАНИЯ СУБНАНОМЕТРОВЫХ СНК ТЕХНОЛОГИИ 16 НМ И НИЖЕ
Authors: Лохов А.Л.
Published: November 2021

Представлен новый подход к физическому проектированию SoC, ориентированный на параметры трассировки (Detailed Routing Centered), включающий элементы физического ресинтеза для оптимизации кристалла и обеспечивающий получение оптимального результата по критерию PPA (Power Performance Area). Такой подход позволяет практически свести к нулю расхождение по оценке задержек после размещения с реальными задержками, полученными после трассировки. Данный подход реализован в платформе Aprisa (произн. «Апрайза») P&R компании Mentor Graphics.
ОРГАНИЗАЦИЯ ПРОИЗВОДСТВА ВЫСОКОНАДЕЖНЫХ ИЗДЕЛИЙ ТВЕРДОТЕЛЬНОЙ СВЧ ЭКБ: ПРОЦЕДУРЫ И ПЕРВЫЙ ОПЫТ
Authors: Филаретов А.Г. , Чалый В.П. , Шуков И.В. , Дудин А.Л. , Фазылханов О.Р. , Красовицкий Д.М.
Published: November 2021

В докладе рассмотрены ключевые аспекты обеспечения надежности твердотельной электронной компонентной базы на стадии ее разработки и производства. Показано, что применение современных концепций, методов и средств испытаний позволяет вывести отечественные компоненты на конкурентоспособный уровень.
АВТОМАТИЗАЦИЯ ПРОЕКТИРОВАНИЯ БЛОКОВ ДЛЯ ПОСТРОЕНИЯ СВЧ МНОГОФУНКЦИОНАЛЬНЫХ ИНТЕГРАЛЬНЫХ СХЕМ НА ОСНОВЕ ОТЕЧЕСТВЕННОЙ 0,25-МКМ GAAS PHEMT-ТЕХНОЛОГИИ
Authors: Сальников А.С. , Горянинов А.Е. , Билевич Д.В. , Метель А.А. , Файль Т.Н. , Новичкова Ю.А. , Попов А.А. , Калентьев А.А. , Добуш И.М.
Published: November 2021

Приведены результаты разработки методик и алгоритмов, позволяющих выполнить автоматизированное проектирование усилительных и логических схем, используемых при построении СВЧ многофункциональных интегральных схем. Исследования проводились на основе 0,25 мкм GaAs pHEMT-технологии (АО «Светлана-Рост»).
АНАЛИЗ СОСТОЯНИЯ РАЗРАБОТКИ ИМС ГУН В ДИАПАЗОНЕ ЧАСТОТ ОТ 2 ДО 28 ГГЦ
Authors: Зайцев А.А. , Вагин А.В. , Баландин Д.А. , Кузьмин А.Д. , Сурков Н.С.
Published: November 2021

Данная работа посвящена анализу состояния разработки интегральных монолитных схем генераторов, управляемых напряжением в современном мире. В статье описаны особенности параметров, представлены варианты исполнения МИС ГУН каждого производителя, также определен максимально востребованный диапазон частот.
ОЦЕНКА РАЗРЕШЕНИЯ ВЫСОКОДЕТАЛЬНОЙ ТВЕРДОТЕЛЬНОЙ СИСТЕМЫ ДЗЗ ОКОЛОЗЕМНОГО БАЗИРОВАНИЯ Х-ДИАПАЗОНА С ПОДТВЕРЖДЕНИЕМ НАТУРНЫМ ЭКСПЕРИМЕНТОМ
Authors: Болтиков Р.С. , Болтиков С.В. , Бурцев Ю.В. , Лычагин А.Ю. , Миннебаев В.М. , Ревонченков А.А.
Published: November 2021

Рассмотрена возможность определения целевых параметров твердотельной субапертурной АФАР с применением широкополосного ЛЧМ-сигнала от начального этапа разработки до верификационных испытаний.
LARVACIDAL EFFECT OF SOME PLANT EXTRACTS AGAINST TOMATO LEAF MINER (TUTA ABSOLUTA MEYRICK; LEPIDOPTERA: GELEHIIDAE)
Authors: Erdogan Pervin , Mustafa Zemran
Published: November 2021

Tuta absoluta Meyrick (Lepidoptera: Gelehiidae) is a significant tomato pest, and chemical pesticides are used extensively for its control. Because of the adverse effects of chemical pesticides, researchers have been paying attention more to biopesticides. In this study, the larvicidal effects of the extracts of Tanacetum vulgare (Asteracea), Aleo vera (L.) and (Liliaceae) Tagetes patula L. (Asteracea) was determined and trials were conducted by using leaf dipping and pot methods. The leaf dipping method was conducted in a climate chamber, whereas the potting experiment was performed in the greenhouse. In all of the experiments, second-stage larvae were used to determine the larvicidal effects. According to the results obtained, the highest larvicidal effect and mortality rate was observed at the highest concentration of T. vulgare extract (86%, effect: 86.55%). The lowest mortality rate and the larvicidal effect was observed at the same concentration of T. patula extract (mortality: 79%, effect: 78.55%). In the pot experiment, the highest yield was seen in the Neem Azal T/S, followed by T. vulgare, A. vera and T. patula extracts. On the first day counts, the lowest insecticidal effect was obtained with the lowest concentration of T. patula extract. The extract of A. vera, T. vulgare and T. patula was effective in experiments carried out in pot and laboratory conditions on T. absoluta. It is suggested that more research be done on using these extracts as a biopesticide to control T. absoluta. Keywords: Tomato leaf miner, plant extracts, larvacidal effect.
A MULTI-PERSPECTIVE ANALYSIS OF AGRICULTURAL POLICIES IN WEST AFRICA: POLICY STRATEGIES FOR RETHINKING SUSTAINABLE AGRICULTURAL DEVELOPMENT
Authors: Bamoi Abdou Gafarou Abdoulaye , Yilmaz Hasan
Published: November 2021

The purpose of this study is to analyze agricultural policies and their changes through a multi-perspective approach and suggest the policy strategies for rethinking Sustainable Agricultural Development (SAD) in West Africa. To reach the study's goal, this paper investigates the structural changes and trends of agricultural policy, the key elements of current agricultural policy, the policy challenges, and instruments suitability. In the study, qualitative analysis was used as a primary research tool. Within this framework, a comprehensive approach enabling holistic assessment, including multi-perspective analysis and the acronym EFFECTIVE as assessment criteria for each policy tool, has been employed. The study results showed that there have been significant changes in West African agriculture over the years in production, modernization and mechanization, agro-food processing, marketing and trade, financing, and policies. Despite these changes, agricultural policies implemented so far could not solve food security, agricultural development, and rural development. Therefore, it is necessary to rethink SAD through a comprehensive agricultural policy approach that simultaneously considers elements, activities, and outcomes of any sub-sector of the agricultural system. The policy strategies should be oriented toward practical and clearly described sub-policies, including specific tools and instruments and strategies related to financing, productivity, cooperation system, and governance for any sub-division of agriculture. Keywords: Agricultural policies, multi-perspective analysis, policy strategies, sustainable, agricultural development, west Africa.
DNA METHYLATION IN PLANTS
Authors: Altaf Adil , Zada Ahmad
Published: November 2021

Common DNA methylation controls gene expression and preserves genomic integrity. Mal methylation can cause developmental abnormalities in the plants. Multiple enzymes carrying out de novo methylation, methylation maintenance, and active demethylation culminate in a particular DNA methylation state. Next-generation sequencing advances and computational methods to analyze the data. The model plant Arabidopsis thaliana was used to study DNA methylation patterns, epigenetic inheritance, and plant methylation. Plant DNA methylation research reveals methylation patterns and describing variations in plant tissues. Determining the kinetics of DNA methylation in diverse plant tissues is also a new field. However, it is vital to understand regulatory and developmental decisions and use plant model species to develop new commercial crops; that are more resistant to stress and yield more. There are several methods available for assessing DNA methylation data. The performance of several techniques is assessed in A. thaliana, which has a smaller genome than hexaploid bread wheat. Keywords: DNA methylation, plants, process, use and benefits
Reformas al régimen patrimonial de la Iglesia Católica sugeridas desde España y Latinoamérica al iniciarse la codificación del derecho canónico de 1917.
Authors: Salinas Araneda Carlos
Published: November 2021

The proposals developed in 1904 by the Spanish and Latin-American bishops –postulata episcoporum– at the beginning of the 1917 codification of canon law, ordered by pope Pius X in motu proprio Arduum sane munus, suggesting reforms to the patrimonial regime of the Church, in response to the consultation made from Rome, by the Holy See Secretary of State in circular letter Litterae circulares ad omnes Episcopos pro Ecclesiae legibus in unum redigendis, are studied. These proposals allow to appreciate the problems that, in terms of assets, the Hispanic-American bishops had in their particular churches. An overview of the contributions received in Rome from the Spanish-speaking churches regarding ecclesiastical assets is presented.
Resistance of Structural Materials to Deformation in the Case of Linear and Flat Stresses
Authors: Xakimov Anvarjon
Published: November 2021

Annotation: The deformation resistance properties of structural materials in the case of linear and flat stresses are given on the basis of experimental results. The method of estimating the mechanical properties of the material based on the initial deformation diagrams is described. Keywords: Stress, deformation, longitudinal force, internal pressure, stress state, deformation diagram, initial deformation, Yung modulus, Poisson's ratio, anisotropy, strength, yield strength
Karakterisasi Adsorben Kulit Durian Tanpa Modifikasi dan Termodifikasi dengan Pelapisan Lateks untuk Penyerapan Rhodamin B
Authors: Suryadri Hadistya , Muis Lince , Lingga Ronado
Published: November 2021

Kulit durian memiliki potensi yang besar untuk dimanfaatkan sebagai adsorben dalam meminimalisir zat pewarna Rhodamin B sebelum dibuang ke lingkungan melalui proses adsorpsi. Lateks diketahui memiliki stabilitas dan kekuatan mekanik yang baik. Oleh karena itu, modifikasi adsorben kulit durian terlapisi lateks dilakukan dengan harapan mampu meningkatkan daya adsorpsi. Daya adsorpsi ditinjau dengan membandingkan karakteristik yang dihasilkan antara adsorben kulit durian tanpa modifikasi dengan adsorben kulit durian yang dimodifikasi dengan pelapisan lateks. Dilakukan analisa SEM untuk mengetahui morfologi adsorben dan analisa EDS untuk melihat unsur-unsur yang terdapat pada adsorben. Dari hasil analisa terbukti bahwa retakan dan patahan yang terbentuk pada adsorben kulit durian tanpa modifikasi diperbaiki dengan pelapisan lateks, menghasilkan pori-pori yang terdistribusi merata dengan ukuran paling kecil 2,814 μm dan paling besar 4,110 μm serta kadar unsur karbon berjumlah 69,27%. Adorben yang dihasilkan kemudian diuji kinerjanya pada penjerapan zat pewarna rhodamin B dalam kondisi asam. Ketika penjerapan, adsorben terlapisi membentuk gumpalan dan tidak terjadi penjerapan. Karakteristik adsorben setelah penjerapan dianalisa menggunakan SEM-EDS, diketahui bahwa akibat terjadinya penggumpalan lanjutan terbentuk pori-pori berukuran kecil padahal kadar unsur karbon yang terdapat pada adsorben berjumlah besar yaitu 82,35%.
Re-sternotomy for aortic valve replacement in octogenarian patients Submission category -- Original article
Authors: Luthra Suvitesh , Malvindi Pietro Giorgio , Masraf Hannah , Podonyi Anna , Ramadan Taha , Ohri Sunil
Published: November 2021

Background The aim of this study was to analyse the
perioperative results and long term survival of re-sternotomy for
surgical aortic valve replacement (SAVR) in octogenarians.
Methods This is a retrospective, single centre study (Apr 2000
– Dec 2019). Perioperative data were compared for re-sternotomy with
isolated SAVR (Isolated redoSAVR) and re-sternotomy with SAVR and
concomitant cardiac procedure (Associated redoSAVR). Regression analyses
were performed to identify predictors of in patient mortality. Hazard
ratios were calculated, and Kaplan Meier survival curves were compared
for groups. Results There were 163 patients (Isolated redoSAVR;
69, Associated redoSAVR; 94). Mean age was 83±3 years and mean
logEuroSCORE was 21±12. Follow up was 4.2±3.5 years. Inpatient mortality
was 4.9% (1.4% versus 7.4% for Isolated redoSAVR and Associated
redoSAVR respectively, p=0.08). TIA/stroke rate was 8% (9% versus 7%
for Isolated redoSAVR and Associated redoSAVR respectively, p=0.78).
COPD was a predictor of inpatient mortality (OR; 8.86, 95%CI; 1.19,
66.11, p=0.03). Survival was 88.7% at 1 year, 86.4% at 2 years, 70.1%
at 5 years, 49.5% at 7 years and 26.3% at 10 years. There was no
survival difference between Isolated redoSAVR and Associated redoSAVR
(logrank p=0.36, Wilcoxon p=0.84). Significant predictors of adverse
long term survival were COPD, postoperative TIA/stroke and length of
stay. Survival is lower than age and gender matched first time SAVR and
general population of UK. Conclusions RedoSAVR in octogenarians
is associated with acceptable but significant morbidity and mortality.
Shared decision making should consider emerging transcatheter therapies
as viable options in selected patients.
The study on general cubic equations over p-adic fields
Authors: Saburov Mansoor , Ahmad Mohd , Alp Murat
Published: November 2021

A Diophantine problem means to find all solutions of an equation or system of
equations in integers, rational numbers, or sometimes more general number
rings. The most frequently asked question is whether a root of a polynomial
equation with coefficients in a p-adic field Qp belongs to domains Z*p, Zp \ Z*p, Qp \ Zp, Qp or not. This question is open even for lower degree
polynomial equations. In this paper, this problem is studied for cubic
equations in a general form. The solvability criteria and the number of
roots of the general cubic equation over the mentioned domains are provided.
B.-Y. Chen’s inequality for pointwise CR-slant warped products in cosymplectic manifolds
Authors: Al-houiti Noura , Alghanemi Azeb
Published: November 2021

Recently, pointwise CR-slant warped products introduced by Chen and Uddin in
[14] for Kaehler manifolds. In the context of almost contact metric
manifolds, in this paper, we study these submanifolds in cosymplectic
manifolds. We investigate the geometry of such warped product and prove
establish a lower bound relation between the second fundamental form and
warping function. The equality case is also investigated.
Establishing a Contingency Plan to Improve Patient Comfort During Peripherally Inserted Central Catheter Insertions: A Quality Improvement Effort
Authors: Wagoner Scott T. , Lorenc Jamie , Edmundson Elizabeth , Schurman Jennifer V.
Published: November 2021

Highlights

Background: Negative outcomes can occur when painful experiences related to needle procedures are not addressed. Patients at the institution in this study were not demonstrating sufficient levels of comfort during peripherally inserted central catheters (PICC) placements, so formal assessment of discomfort or distress began via the Pediatric Sedation State Scale (PSSS), and an enhanced approach to comfort planning, built around the Comfort Promise, was implemented. Over 1 year, we aimed to increase the percent of patients meeting sufficient comfort during PICC insertions by our Vascular Access Team (VAT) from 54% to 65%.

Methods: Initially, VAT staff were educated on use of the PSSS and began routinely charting the highest score obtained during each PICC placement. Interventions were delivered concurrently and included (1) changing the VAT culture, (2) process development, (3) consensus building and scale up, and (4) information system modifications. Results: During the project period, 421 PICC insertions were completed. From baseline to the last 8 months, the percent of patients rated as experiencing sufficient comfort (PSSS = 2–3) during PICC placement increased from 54% to 74%, with the percent of patients experiencing significant discomfort or distress (PSSS = 4–5) decreasing from 45% to under 7%.

Conclusions: Success in this project required a culture change. Building consensus by engaging others and integrating with the processes, preferences, and priorities of each area was key. Future work will focus on increasing use of all Comfort Promise bundle elements, identifying patients at risk for escalation, and taking a long-term view to comfort planning, as well as applying lessons learned to other needle procedures.
Prevalence and Predictors of Household Food Insecurity and Supplemental Nutrition Assistance Program Use in Youth and Young Adults With Diabetes: The SEARCH for Diabetes in Youth Study
Authors: Malik Faisal S. , Liese Angela D. , Reboussin Beth A. , Sauder Katherine A. , Frongillo Edward A. , Lawrence Jean M. , Bellatorre Anna , Pihoker Catherine , Loots Beth , Dabelea Dana , Mayer-Davis Elizabeth , Jensen Elizabeth , Turley Christine , Mendoza Jason A. , Study the SEARCH for Diabetes in Youth
Published: November 2021

OBJECTIVES:
To assess the prevalence of household food insecurity (HFI) and Supplemental
Nutrition Assistance Program (SNAP) participation in youth and young adults (YYA)
with diabetes overall, by type, and sociodemographic characteristics.

RESEARCH DESIGN AND
METHODS: The study included participants with youth-onset type 1
diabetes and type 2 diabetes from the SEARCH for Diabetes in Youth study. HFI
was assessed using the 18-item U.S. Household Food Security Survey Module (HFSSM)
administered from 2016-2019; ³3 affirmations on the HFSSM were considered indicative
of HFI. Participants were asked about SNAP participation. Chi-square tests were
used to assess whether the prevalence of HFI and SNAP participation differed by
diabetes type. Multivariable logistic regression
models were used to examine differences in HFI by participant characteristics.

RESULTS: Of 2561
respondents (age range 10-35 years; 79.6% ≤ 25 years), 2177 had type 1 diabetes
(mean age 21.0 years, 71.8% non-Hispanic white, 11.8% non-Hispanic black, 13.3%
Hispanic, 3.1% other) and 384 had type 2 diabetes (mean age 24.7 years, 18.8%
non-Hispanic white, 45.8% non-Hispanic black, 23.7% Hispanic, 18.7% other). The
overall prevalence of HFI was 19.7% (95% CI 18.1, 21.2). HFI was more prevalent
in type 2 diabetes than type 1 diabetes (30.7% vs. 17.7%, p< 0.01). In
multivariable regression models, YYA on Medicaid/Medicare or without insurance,
with lower parental education, and with lower household income had greater odds
of experiencing HFI. SNAP participation was 14.1% (95% CI 12.7, 15.5) with
higher participation among those with type 2 diabetes compared to type 1
diabetes (34.8% vs. 10.7%; p<0.001).

CONCLUSIONS: Almost 1
in 3 YYA with type 2 diabetes and more than 1 in 6 with type 1 diabetes reported
HFI in the past year, a significantly higher prevalence than the general U.S.
population.
Non-intrusive reduced order modelling for aerodynamic applications
Authors:   , Balla Kensley
Published: November 2021

During the design and optimisation of aerodynamic components, the simulations to be performed involve a large number of parameters related to the geometry and flow conditions. In this scenario, the simulation of all possible configurations is not af-fordable. To overcome this problem, the present work proposes a novel multi-output neural network (NN) for the prediction of aerodynamic coefficients of aerofoils and wings using compressible flow data. Contrary to existing NNs that are designed to predict aerodynamic quantities of interest, the proposed network considers as output the pressure or stresses at a number of selected points on the aerodynamic surface. The proposed approach is compared against the more traditional networks where the aero-dynamic coefficients are directly the outputs of the network. Furthermore, a detailed comparison of the proposed NN against the popular proper orthogonal decomposi-tion (POD) method is presented. The numerical results, involving high dimensional problems with flow and geometric parameters, show the benefits of the proposed ap-proach.The proposed NN is used to accelerate the evaluation of the objective function in an inverse aerodynamic shape design problem. The optimisation algorithm uses the gradient-free modified cuckoo search method. Applications in two and three dimen-sions are shown, demonstrating the potential of the proposed framework in the con-text of both optimisation and inverse design problems. The performance of the pro-posed optimisation framework is also compared against existing frameworks where the more traditional NNs are employed.
Correlation of Oxygen Consumption and Patient Day with Invasive Mechanical Ventilation in a Hospital in Sao Paulo during Covid-19 Pandemic
Authors: Bin Kaio Jia , Machado Luana Alcantara , Junior Nivaldo Fracacio , Tomazini Francis Mironescu , De Camargo Paula Cristina Souto , Hangai Rosemeire Keiko , Camarotto Marcelo , Tanaka Clarice , Pereira Antonio José Rodrigues
Published: November 2021

Background: The new coronavirus led the world into the pandemic known as COVID-19. Still, without any effective treatment, oxygen therapy is the most used treatment for patients. Without proper management of this medicinal gas, lives can be lost for lack of it. Aim: Find an indicator of a strong correlation with oxygen consumption. Methods: A single-center retrospective study, that evaluated the oxygen consumption billing data and patient-day indicator of Central Institute of HCFMUSP between 2019 and 2020. Results: A total of 380,245 patient days were analyzed. A strong correlation was identified between oxygen consumption and patient day with invasive mechanical ventilation (0.92). An average of 41.6 (± 7.8) cubic meters per patient day with invasive mechanical ventilation was found. Conclusion: There is a strong correlation between oxygen consumption in cubic meters and patient days with invasive mechanical ventilation at the Central Institute of HCFMUSP. The average values of consumption per patient day can help in planning oxygen management in other hospitals.
PECULIARITIES OF EXPANDED NEWBORN SCREENING FOR THE INHERITED METABOLIC DISORDERS IN PREMATURE NEWBORNS
Authors: Znamenska T. , Vorobiova O. , Kuzneczov I. , Lastivka I. , Holota T. , Kremezna A. , Kryvosheieva V. , Obod M. , Samoylenko I.
Published: November 2021

Occurrence of the premature birth in Ukraine is about 6%. Premature newborns are the highest risk group of developing chronic pathology of the nervous system, sensory organs, and respiratory system, causing neonatal mortality and disability; the latter is 22 times higher in premature newborns than in full-term ones. Besides, there is a large group of rare metabolic disorders that significantly disrupt the adaptation and nursing of newborns with signs of morpho-functional and enzymes immaturity. The efficacy of medical care of premature newborns to a great extent relates to prompt diagnosis as common somatic, as rare metabolic disorders.In view of the absence of specific symptoms, it is almost impossible to establish a diagnosis of inherited metabolic disordersduring the clinical examination of a neonate.Expanded newborn screening (ENBS) for inborn errors of metabolism (IEMs) proved to be an effective tool to single out newborns with genetic deficiency of certain metabolic enzymes.The practical experience of performingENBS indicates a problematic issue is the interpretation of results for preterm babies.This article is discussed the key factors affecting the predictive value of ENBS results in premature newborns, like peculiarities of blood sampling based on time intervals from delivery for certain nosologies, repeated sample taking for lab examination considering the basic principles of 2-nd Edition of CLSI "Guideline "Newborn Screening for Preterm, Low Birth Weight, and Sick Newborns, 2019". The CLSI Guideline presents the consensus solutions of a global team of neonatologists, metabolic paediatricians and medical geneticists regarding the accuracy, reliability and timing of laboratory determinations of IEM markers in the blood, as well as a set of factors to consider interpreting ENBS results for premature, low birth weight and newborns with perinatal pathology.The current procedure for neonatal screening for premature babies in Ukraine should be updated to modern requirements of the relevant clinical recommendations of world-recognized medical institutions, including CLSI. The critical issue in improving the quality and reliability of neonatal screening for preterm babies is multiple (repeated) blood sampling for laboratory determination of levels of biochemical IEM markers.A properly established and well- functioning system of expanded neonatal screening proved to be a highly effective tool for reducing early infant mortality and disability associated with inherited metabolic diseases.
NEW APPROACHES TO THE DEFINITION AND CLASSIFICATION OF BRONCHOPULMONARY DYSPLASIA IN PRETERM INFANTS
Authors: Menshykova A. , Dobryanskyy D.
Published: November 2021

Bronchopulmonary dysplasia (BPD) remains a pressing problem of modern neonatology and pediatrics. Since this disease is chronic and often results in negative long-term consequences, the search for the optimal definition of BPD that would be accuratein predicting long- term respiratory and neurological outcomes is ongoing. It has been 20 years since the definition and classification of BPDs that are currently used had been approved. Over time, the patient population prone to BPD development has changed and new factors have emerged that make it difficult to apply this classification in contemporary clinical practice. In particular, it concerns greater survival of extremely premature infants, which form the majority of patients with BPD. Oxygen dependence during the first month in such infants may be determined by the immaturity of the respiratory system and may not be associated with the development of BPD. Also, new methods of respiratory support have been introduced into practice of intensive care units, which is not accounted for by the current classification. The population of infants with severe BPD, according to classical definition, is heterogeneous with different indicators of long-term chronic morbidity and development. All this justifies the need for new methodological approaches and criteria for the definition and classification of BPD in the modern population of premature infants.This review presents new data, proposals and clarifications for the definition and classification of BPD, which take into account modern features of clinical practice.
Differential expression of antioxidant genes during clinical mastitis of cow caused by Staphylococcus aureus and Escherichia coli
Authors:   Department of Clinical Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran, Asadpour Reza , Zangiband Pedram , Nofouzi Katayoon , Saberivand Adel
Published: November 2021

There is considerable interest in the hypothesis that oxidative stress is enhanced in the pathophysiology of clinical mastitis. The main goal of this research was to establish profiles of antioxidant gene expression in the milk of cows with clinical mastitis. Standard bacteriology was conducted on pretreatment milk specimens from 77 cows with clinical mastitis between 15 and 70 days in milk (DIM). Examinations were performed on mRNA expression of antioxidant genes, such as catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD). Additionally, levels of lipid peroxidation were measured in milk samples from healthy cows and those with clinical mastitis. The isolated bacteria consisted of Staphylococcus aureus (S. aureus, 10.48%), Streptococcus agalactiae (7.69%), Streptococcus dysagalactiae (6.29%), and Escherichia coli (E. coli, 29.37%). E. coli was the most prevalent pathogen found in the milk of cows with clinical mastitis in early lactation. The mean level of malondialdehyde (MDA) in clinical mastitis samples was significantly higher (P<0.05) than that of healthy cows. The results revealed that the expression profiles of SOD in mastitis milk induced by S. aureus were significantly (P<0.0001) up-regulated compared with E.coli. In addition, the mRNA levels of GPx in mastitis milk due to E.coli were significantly (P<0.0001) over expressed compared to S. aureus. CAT gene expression had a tendency to be enhanced in mastitis milk induced by S. aureus compared with mastitis in cows due to E.coli. These results showed that the mRNA levels of antioxidant genes may differ depending on the type of bacteria, and diminished expression of antioxidant genes might increase susceptibility to mastitis.
Detection of five substitution TPO mutations in Polycystic Ovary Syndrome (PCOS) and thyroid hormones disturbance patients
Authors: Al-Deresawi Mahdi Saber G. , Al Najar Ali Fadhel , AlFaisal Abdul Hussein M.
Published: November 2021

Polycystic ovary syndrome (PCOS (is a complex disorder which reflects variable clinical symptoms. There is considerable heterogeneity of symptoms and signs among women with PCOS, and for an individual, these may change over time. The genetic base of PCOS is not clear and no concrete genetic correlation was built with PCOS. The current study showed the presence of multiple peripheral small cysts 5-9 mm also there was an increase in ovarian volume 3.7-3.9 cm and change in ovarian dimensions with the ovary being more spherical. 20.8% of the PCOS patients included in this study found to have hyperthyroidism. Thethyroid stimulating hormone-TSH level was significantly higher 17.34±5.12μIU/ml in 4 POCS patients with thyroid hormones disturbance than the level in POCS patients without thyroid disturbance or healthy control group )2.19 ±0.47 and 2.33±0.44 μIU/ml respectively(. On the other hand, the rest of POCS patients with thyroid hormones disturbance 7 Patients showed lower significance levels of triiodothyronine-T3 and thyroxine-T4 (0.96±0.029 and 51.33± 10.96 n.mol/L respectively) than other groups. At the molecular analysis five substitution thyroid peroxidase genes -TPO mutations were detected in 5 patients with PCOS and thyroid hormones disturbances. Three of them were detected in exon 8 and two in exon 9. The missense substation mutations detected in this study involve one transition of T to C (c.904T>C) and 4 transversion of C to G, C to A and G to C (c.904T>C, c.1280C>G, c.1265C>A, c.1617G>C and c.1603G>C respectively).
Суверенитет и его воплощение во внутригосударственном и международном праве
Authors: Ушаков Н. А.
Published: November 2021

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Constructores en el arte de imprimir: editores, impresores y preceptores. Florencio Aburto y Agustín Ruiz, 1847-1878
Authors: Alarcón Morales Marisol
Published: November 2021

Los estudios de la labor realizada por los impresores decimonónicos y la profesionalización del quehacer periodístico han adquirido relevancia entre los estudiosos de la cultura, la prensa y el periodismo; a pesar de su importancia, siguen siendo escasos. Por ello, en este texto se presenta la labor y la producción editorial de Florencio Aburto y de Agustín Ruiz, actores sociales que conjuntaron una actividad intelectual en el mundo de la impresión, el diseño y la edición, convertidos en los principales impulsores de la cultura escrita en la ciudad de Xalapa de las primeras cuatro décadas del siglo XIX.
Medios, globalización y terror político: la transformación de los estudios de comunicación internacional
Authors: Castells i Talens Antoni
Published: November 2021

Este ensayo explica la transformación de los estudios de la comunicación internacional desde el final de la Guerra Fría y plantea los retos que afronta la docencia de esta disciplina compleja y en constante transformaciЧn con la aparición de nuevas formas de terror político globalizado. Basado en el caso de las representaciones mediáticas de Mahoma en Europa y Estados Unidos y en sus repercusiones globales, el artículo sugiere maneras de abordar este nuevo terror político en la docencia de comunicación. La importancia de los medios en este conflicto lo convierten en un estudio de caso óptimo para actualizar la docencia de temas de comunicación internacional como conceptos de prensa y res ponsabilidad social; censura e intervención gubernamental en la comunicación; el flujo internacional de la información o el papel de las TIC en las relaciones internacionales.
Mardencuentros
Authors: Domínguez Cuenca Daniel
Published: November 2021

En el presente ensayo se recuerda la actividad del cineasta Rafael Corkidhi en Boca del Río, Veracruz, durante el ocaso de su vida, donde fundó la escuela de cine nombrada, precisamente, con una sola palabra: Mardencuentros. De manera muy personal el autor presenta el retrato de un creador fuera de lo común, quien dedica la última parte de su vida a la enseñanza de manera independiente, con su proyecto dirigido a jóvenes de bajos recursos –entre ellos niños de la calle. Además se deja ver la importancia del sitio físico de la escuela y su lugar en la cultura histórica de Boca del Río.
La muerte y los muertos en la santería afrocubana
Authors: Celecia Pérez Cosette
Published: November 2021

Este artículo aborda el lugar que ocupa la muerte dentro de la Santería en Cuba. Primero, nos referiremos brevemente el origen de lo que hoy se conoce como Santería, Regla de Ocha, religión Yoruba o religión Lucumí, expresión del sincretismo cultural de la isla. Posteriormente, analizaremos la presencia de los muertos en la ritualidad yoruba y la importancia de la voz y el lenguaje en las ceremonias mágico religiosas que buscan la conexión de los vivos con los espíritus de antepasados.
Violencia y transformación del habitus periodístico en Veracruz:caso Notiver (2011-2013)
Authors: H. Mar Guadalupe
Published: November 2021

En este artículo se pretende dar cuenta de la transformación que han tenido las prácticas periodísticas en la zona conurbada de Veracruz-Boca del Río, entre 2011 y 2013, periodo en el que fueron asesinados nueve periodistas en el estado, tan sólo en esos dos años. Se da seguimiento a los artículos publicados en la sección de nota roja del diario Notiver, donde laboraba la mayor parte de los periodistas asesinados en dicho periodo. Con el análisis realizado a estas notas, además de las entrevistas con los directivos del diario, se corrobora que hubo una transformación importante en las representaciones de la violencia en el diario, pasando de la “nota roja” a la “nota rosa”, como los mismos trabajadores del diario apuntan, así como un cambio notable en el habitus periodístico de los trabajadores.
Cámara nupcial. Jorge Esquinca
Authors: Fernández Ángel José
Published: November 2021

Jorge Esquinca ha escrito un libro misceláneo, un collage de múltiples evocaciones, teniendo como figura central, como objetivo único, a la figura focalizada de la poetisa norteamericana Emily Elizabeth Dickinson (1830-1886). ¿Será este juguete de Esquinca un ejercicio heteronómico?
Guadalajara celebra la 32ª edición del Festival Internacional de Cine de Guadalajara (FICG)
Authors: Castillo Del Razo Daniel
Published: November 2021

En un gran despliegue de producción y colaboración humana, la capital del estado de Jalisco albergó la 32ª edición del consolidado y reconocido Festival Internacional de Cine en Guadalajara (FICG), que se llevó a cabo del 10 al 17 de marzo de 2017 y que tuvo como invitado de honor a Alemania.
Estudios culturales y laborales del periodismo: una revisión bibliográfica
Authors: Reyna García Víctor Hugo
Published: November 2021

Este artículo es un estado del arte sobre dos de las líneas de investigación más fértiles en el campo de los estudios del periodismo: los estudios culturales y laborales del periodismo. El primer apartado revisa los estudios culturales del periodismo, con énfasis en la producción académica sobre las normas profesionales, las identidades profesionales y los procesos de profesionalización. El segundo apartado examina los estudios laborales del periodismo, con atención en las investigaciones sobre la seguridad laboral, la cualificación del trabajo y la satisfacción laboral. Interesa analizar las tendencias generales del campo de los estudios del periodismo y observar su desarrollo a nivel continental y nacional.
Fragmentación, familia e identidad en Misión de Chichimecas, San Luis de la Paz, Guanajuato
Authors: Villegas Ortiz Ana Elizabeth
Published: November 2021

Este texto presenta una primera aproximación al estudio de la organización familiar, el parentesco, las políticas públicas y la identidad, en una comunidad indígena del estado de Guanajuato. El documento se apoya en la revisión de fuentes históricas y en información de primera mano recabada a partir del trabajo de campo realizado en dicha comunidad entre 2010 y 2012. Los datos obtenidos a través de entrevistas, recorridos y observación participante se han complementado con información bibliográfica sobre el área de estudio.
La soledad ontológica dentro del filme El tunco Maclovio de Alberto Mariscal
Authors: González Moreno Obed
Published: November 2021

En este ensayo se analiza la cinta cinematográfica El tunco Maclovio como una mínima parte de una investigación en relación con el tiempo interno y con la soledad del mexicano en el libro El laberinto de la soledad de Octavio Paz, a través del cine mexicano. Se retoma la concepción de Martin Heidegger sobre el ser y el tiempo, para discernir sobre el ser y el estar. Asimismo, se deconstruye la cinta referida por medio del discurso escrito, para que dentro de él se observe la poética como la acción que lleva a algo a ser otro, sin dejar de ser el mismo, y a la vez mostrar esta paradoja con el personaje de Maclovio Castro, protagonista del filme.
De maestros, amigos y colegas. Una historia personal de la historia cultural contemporánea mexicana
Authors: Pérez Monfort Ricardo
Published: November 2021

En el presente artículo, el autor hace un recuento de los vínculos particulares y personales con la historia cultural, tras más de 30 años de labor en esa esfera de conocimiento que escapa de una definición precisa.
Regulación de las residencias médicas en México y derechos humanos
Authors: Jongitud Zamora Jaqueline del Carmen , Vázquez Martínez Francisco Domingo
Published: November 2021

RESUMEN: En este artículo se analiza, desde el Derecho Internacional de los Derechos Humanos, la forma en que la NOM-001-SSA3-2012 relativa a educación en salud y a la organización y funcionamiento de residencias médicas protege el derecho a la formación de recursos humanos en materia de salud. Del mismo modo, se analiza el proyecto de norma oficial con el que pretende sustituírsele.
Testamento y herencia digital
Authors: Adriano Fabre Armando , Hernández Sánchez Modesta Lorena
Published: November 2021

RESUMEN: De acuerdo con los Códigos Civiles -federal y estatales- la regulación del testamento en México se ciñe sobre diversos supuestos en los que de forma oral o escrita y desde diferentes escenarios, el testador puede establecer las condiciones que estime pertinentes para que se disponga de sus bienes y derechos, así como para que se cumplan determinados deberes después de su muerte. Partiendo de esa lógica, la información procedente de cuentas electrónicas de facebook, twitter, instagram, redes de mensajería, blogs, entre otros, también integran los bienes del ciudadano, en razón a que su presencia en la red está conformada con sus datos personales. Lo anterior, pone de manifiesto la necesidad de que la normativa en materia de sucesiones debe transitar hacia un nuevo paradigma que reconozca la regulación de los derechos que deriven del uso de las tecnologías de la información y comunicación como parte de nuestras actividades laborales, académicas, profesionales o recreativas. Tal es el caso de Francia y España, que han demostrado estar a la vanguardia al contemplar en sus legislaciones civiles la regulación del testamento digital, a fin de garantizar la gestión adecuada de las cuentas online de cualquier modalidad, después de la muerte de su titular.
Segundo Congreso de Derecho Constitucional Iberoamericano. Preludio a Cátedra Mahatma Gandhi-Universidad Veracruzana
Authors: León López Rita María
Published: November 2021

RESUMEN: Se reseñan los planteamientos principales de las conferencias magistrales y las temáticas que se expusieron en el segundo Congreso de Derecho constitucional Iberoamericano, en su segunda edición y primera en modalidad virtual, realizado del 23 al 25 de febrero del presente año.
Legal policy of the European Union against counterfeiting in the conditions of Digital Single Market
Authors: Shugurov Mark Vladimirovich
Published: November 2021

The subject of this research is the legal policy of the European Union against counterfeiting in the conditions of functioning of the Digital Single Market. The goal is to determine the content and patterns of development of this policy from the perspective of combining traditional and innovative measures and initiatives aimed at prevention of trafficking of counterfeit goods in the digital environment. Special attention is given to the analysis of the key factors of formation formation of this policy, taking into account the implementation of the Strategy of the Digital Single Market. The author analyzes the dynamics of application of the organizational-legal mechanisms for combating counterfeiting, and the multi-stakeholder approach that lies beneath them. Separate section of the article is dedicated to establishment of the principles of using voluntary measures on prevention and suppression of the trafficking of counterfeit goods in the digital environment. The conclusion is made that the theoretical provisions indicating that the EU anti-counterfeit policy is aimed the development of supranational block of legal instruments related to the sphere of intellectual property law and customs regulation, and represents a system of comprehensive actions, each of which is implemented depending on the thematic agenda reflecting the strategic intentions for action. The author’s special contribution lies in determination of the patterns of transition towards the regime of responsibility of online platforms that allow posting the offers of counterfeit products. The novelty of this article consists in demonstrating the effective combination of non-legislative and legislative measures used on the supranational level for protecting intellectual property in the conditions of the development of digital environment.
СИСТЕМАТИЗАЦІЯ НАУКОВИХ ПІДХОДІВ ДО ВИЗНАЧЕННЯ СУТНОСТІ ТА ЗМІСТУ ПОНЯТТЯ «ПОДАТКОВА КУЛЬТУРА»
Authors: Sushkova Olena , Melnyk Liliіa
Published: November 2021

У статті досліджено й систематизовано наукові підходи до визначення сутності та змісту поняття «податкова культура». А саме, виділено п’ять підходів до трактування податкової культури: частина загальної культури (морально-етичні норми), складова економічної культури, ступінь відповідальності платника податків, культура платника податків і працівника контролюючих органів, формальні й неформальні інституції (інституціональний аспект) Структуровано і виділено основні ознаки «податкової культури». Сформоване власне визначення податкової культури як інструменту, що дозволяє формувати сприятливе ставлення платників податків до обов’язків щодо їх сплати та підтримувати в суспільстві високий рівень податкової дисципліни.