bluuebunny/crossref_metadata_2025 huggingface dataset:
COLLLABORATIVE STRATEGIC READING (CSR) IN THE EFFECTIVENESS OF TEACHING READING COMPREHENSION
Authors: Nur Reformista Muhabibah , Arifah Khofshoh Zanubah
Published: April 2022

This research aims to determine the effectiveness of using CSR technique in teaching reading comprehension at Class IXB MTs. Miftahul Jinan Glugu. This research method is quantitative descriptive with pre-experimental research design, this research in the form of one group pre-post-test. Based on the results of the pre-test it got an average score of 51.58, increasing in the post-test with an average score of 82.11. And then at table of the pair-sample t-test with the basis for making decisions, namely if sig.  (2-tailed) < 0.05 then H0 is rejected and Ha is accepted.  The result of the value of sig. (2-tailed) in this research is 0.000 <0.05, then H0 is rejected and Ha is accepted. The results of this research can be concluded that CSR technique is effective in teaching reading comprehension at class IXB MTs. Miftahul Jinan Glugu.
Penggunaan Model Discovery Learning dengan Metode Demostrasi Untuk Meningkatkan Ketuntasan Belajar Siswa SMAN 3 Bangkalan
Authors: Sartunut Sartunut
Published: April 2022

This study aims to determine the mastery and student learning activities in learning activities through discovery learning models with demonstration methods on the material factors that affect the rate of reaction. The subjects of this study were students of class XI–MIPA-1 SMAN 3 Bangkalan. This research design uses classroom action research with two cycles and each cycle is carried out in two meetings. Each cycle consists of planned activities and observations, reflections and revised plans. The research was conducted in the odd semester of the 2018/2019 academic year. Methods of collecting data using tests, teacher and student activity observation sheets. From the results of these studies, it can be concluded that the application of the learning model of discovery learning with the demonstration method can increase the activity and learning mastery of class XI-MIPA-1 SMAN 3 Bangkalan on the Reaction Rate material. The percentage of classical completeness in the first cycle was 55.9% and in the second cycle increased to 82.4%. While the percentage of student activity was 70.7% in cycle 1 and cycle II increased to 80%.
APLIKASI DESMOS DALAM PENYELESAIAN MASALAH PERSAMAAN TRIGONOMETRI
Authors: Isroil Ahmad , Khairul Umam Ahmad , Supriyanto Supriyanto
Published: April 2022

Era digital menuntut segala bentuk aktivitas dikerjakan dengan cepat, efektif, dan efisien, dengan pemanfaatan teknologi yang mutakhir. Pada era reformasi teknologi 4.0 saat ini, berbagai informasi dapat diperoleh dalam waktu yang singkat melalui perangkat pintar dengan aplikasi tertentu, salah satunya adalah aplikasi untuk menyelesaikan masalah persamaan trignometri sederhana. Penyelesaian masalah persamaan trigonometri memerlukan suatu usaha perhitungan yang teliti dan kompleks. Pada artikel ini penulis menguraikan sebuah aplikasi untuk penyelesaian masalah persmaaan trigonometri secara efektif, cepat, dan akurat dengan menggunakan aplikasi desmos.
OUTCOME OF USING PLATELET, PLASMA AND GROWTH FACTORS AS AN ORTHOBIOLOGIC DERIVATIVE TO AVOID INVASIVE SURGICAL PROCEDURES FOR TREATING KNEE OSTEOARTHRITIS AMONG ELDERLY PATIENTS
Authors: Turjane Thana , Saengsirinavin Pamok , Sriratanavudhi Chaivat , Cheeva-akrapan Vorasilp , Larpaiwong Wanpen , Aojanepong Jongjate
Published: April 2022

Background: The application of platelet, plasma and growth factors (PP&GF) is an intra-articular orthobiologic intervention that has been proven to be safe, having less systemic complications compared with conventional treatments and could constitute an option for treating elderly patients with knee osteoarthritis (OA). However, an intermediate result of using PP&GF has yet to be well established.

Objectives: This study aimed to report the survival analysis of 24-month follow-up treatment using PP&GF among elderly patients with knee OA as primary outcome. The secondary outcomes were functional improvement in terms of international knee documentation committee (IKDC) score, Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) score and visual analog scale (VAS) pain score.

Methods: A prospective cohort study was performed among patients with knee OA (Kellgren and Lawrence (KL) grade I-IV), aged more than 65 years who did not respond to conservative treatments. All patients received intra-articular PP&GF treatment and were followed up to 24 months. Primary outcome was recorded as any surgical treatment at any time point post-PP&GF injection. Secondary outcomes including IKDC, WOMAC and VAS pain score were also assessed.

Results: A total of 184 participants were enrolled in this study. The overall survival rate of patients not undergoing any surgical procedures during 24-month follow-up was 87.50%±2.44%. The mean IKDC, WOMAC and VAS pain scores were 39.59±0.58, 55.9±1.09 and 6.63±0.13, respectively at baseline while those at 24-month follow-up were 46.77±0.81, 38.32±1.33 and 4.92±0.13, respectively. The mean platelet concentrations before and after centrifugation were 1.85x105 cells/μL (1.20-3.36x105 cells/μL) and 1.4x106 cells/μL (5.80x105-3.5 x106) cells/μL, respectively, which showed final PP&GF products contained 6-10 times higher platelet concentration than those in the peripheral blood.

Conclusion: Intra-articular injection of PP&GF is a potential treatment for severe knee OA especially among elderly patients. This method provided 87.50% survivorship from surgical intervention at 24-month follow-up. Most patients improved both pain and functional outcomes. We propose that the optimal preparation technique for PP&GF is the key step for improving patients’ clinical outcomes and regaining their quality of lives.
IoT and Wireless Communications: An Overview
Authors: Paliwal Mrinal , Saraswat Pankaj
Published: April 2022

The fundamental premise behind this notion is that the Internet is present all around us in the form of a variety of items or objects such as mobile phones, computers, and everyday goods such as refrigerators, TVs, and smart sensors. The idea of the Internet of Things shortly referred to as an IoT was driven by technological advancements that allowed effective wireless small devices. Between 2015 and 2020, mobile data traffic is projected to increase eightfold, and the number of mobile connected devices will reach 11.6 billion. The integration of several technologies and communications solutions, such as wired and wireless sensor and actuator networks, next-generation communication protocols, identification technologies, and artificial intelligence for smart objects, are key factors in this exponential growth and widespread acceptance. We analyze the role of the Internet of Things in different areas, consider technical issues, and assess the problems and possibilities that the Internet of Things presents in this paper.
EDUCATIONAL DATA MINING AND DATA WAREHOUSE DESIGN USING BUSINESS INTELLIGENCE
Authors: Saraswat Pankaj , Raj Swapnil
Published: April 2022

Business intelligence (BI) is basically a collection of programs, utilities and apps that allows you to analyze large quantities of data (Big Data). Every year, educational institutions deal with enormous amounts of Big Data. The use of business intelligence (BI) in these organizations is critical for improving processes and supporting decision-making. A Datawarehouse is the foundation of every BI project (DW). The scheme deliberations for implementing DW in any of the institutional setting are described in this article. Using educational data mining (EDM) methods, the DW shall be utilized in an information unearthing procedure to manage the statistics and facts for the study of vital accomplishment metrics. A knowledge management framework's main technical assets are a data warehouse (DW) and an enterprise architecture (EA) repository (KMF). The agenda further was created to provide order to the processes of knowledge generation, capture, transfer, and digitization. This handbook and the framework are two of the results of a private university's research effort. In addition, an illustrative example demonstrates picking of the finest technique in higher education. The stages for DW design are given in the case study. This research may help academics and practitioners who want to create a data warehouse to analyze data utilizing EDM methods.
STURDY DATA WAREHOUSE FOR COMPLEX DATA OF TRAVEL SURVEY
Authors: Solanki Madhav Singh
Published: April 2022

The data warehouse enables information to be organized in order to ease data handling from one sphere to the other and to promote knowledge acquisition. The requirement for a consistent organization and compatibility across various data sources grows as the quantity of data grows, making it more difficult to conduct thorough analyses within short periods. This study offers a trip data warehouse that uses dimensional modeling to promote a more comprehensible structure, comparable findings, quicker data access, and faster publishing of summaries. The use of multivariate representation to transport information helps to improve construction while also integrating, augmenting, and improving data. It performs data processing and validation in an automated manner. The development of transportation planning tools is anticipated to lead to the creation of a multivariate representation for trip data. In future, there is a pragmatic scope of extensive research in this field.
Monitoring of Climatic Factors Affecting on Dust & Sand Storm in Tehran Province
Authors:   Soil Conservation and Watershed Management Department, Agricultural and Natural Resources Research and Education Center of Tehran Province, AREEO, Tehran Iran., Sharifi Rahman
Published: April 2022

In this study, according to the objectives and implementation method, climatic factors affecting ‎the dust phenomenon in active meteorological stations in Tehran province for a period of 30 years ‎were studied and analyzed. The results showed that in Mehrabad meteorological station, ‎temperature, humidity, rainfall, evaporation factors were directly related to DSI indices, wind ‎trend and dust storm changes, Lancaster, wind and storm diagrams, SPEI and the increase of ‎drought indices in the statistical period increased with temperature, evaporation and decrease. ‎Rainfall and humidity are proportional. DSI dust storm indexes were compared to 1 and ‎Lancaster drought index was compared to 50 and SPEI index was compared positively and ‎negatively in different years of the statistical period in the region and was classified in terms of ‎drought and wet season. The results of monthly and annual changes in wind trend and dust ‎storms showed that the region has no wind in all months and seasons with a speed of more than ‎‎20 meters per second. In terms of wind speed and frequency percentage, the highest wind speed ‎was related to late May and early June, and the lowest wind speed was related to late December ‎and early January. In addition, according to the changes in the wind trend and the documents of the ‎winds and thunderstorms, the prevailing wind direction in the region was from the west.‎
Analisa Kelayakan Usaha Pembuatan Selai Apel di UMS Rappang Storea
Authors: Qisti Nurul , Nurwidah Andi , Padapi Astrini , Hariyono Iranita
Published: April 2022

Buah apel mengandung banyak komponene gizi, baik mineral maupun vitamin. Salah satu produk yang dijual di UMS Rappang Store yakni buah apel. Buah apel merupakan buah yang mudah rusak sehingga untuk menambah nilainya dengan melakukan pengolahan produk. Pengolahan yang dilakukan yakni pembuatan selai. Selain itu, dilakukan analisa kelayakan usaha untuk mengetahui layak atau tidaknya dilakukan pembuatan selai apel untuk alernatif usaha. Hasil yang didapatkan dalam analisis ini adalah usaha pembuatan selai apel layak untuk dilakukan.
Pemberdayaan Masyarakat: Peningkatan Usaha Desa Berbasis Keunggulan Lokal di Desa Santan Tengah Kabupaten Kutai Kartanegara
Authors: Budiman Budiman , Alaydrus Anwar , Jumansyah Jumansyah , Syarifuddin Tengku Imam , Wahyuni Anita
Published: April 2022

Abstrak

 

Meningkatkan peluang dan potensi usaha desa berbasis keunggulan lokal bertujuan untuk  mengoptimalkan pembangunan  Desa Santan Tengah dengan menggali potensi desa Santan Tengah yang kurang diketahuai oleh pemerintah desa dan diminati oleh masyarakat, sehingga kedepan desa Santan Tengah dapat menjadi desa mandiri melalui keunggulan lokal. Tahap awal kegiatan, akan dilakukan pembahasan awal dengan pihak pemerintah desa untuk mendapatkan gambaran umum terkait desa Santan Tengah, selanjutnya akan dilakukan survei potensi desa dengan kerja sama pihak desa. Tahap selanjutnya dari hasil survei tersebut dilakukan pembahasan bersama pihak desa dan beberapa perwakilan masyarakat untuk menentukan skala prioritas keunggulan desa yang dapat memberikan dampak signifikan terhadap pembangunan desa kedepan melalui usaha desa. Kemudian di sosialisasikan  kepada masyarakat dalam rangka meciptakan kesadaran akan keunggulan desa yang dapat menjadi peluang dan potensi kemandirian ekonomi masyarakat desa. Luaran dari kegiatan ini berupa rekomendasi perencanaan strategis peningkatan uasaha desa, publikasi tulisan penciptaan desa madiri dan rencana prioritas usaha desa akan isosialisasikan secara daring dan luring secara berkelanjutan agar masayarakat dapat aktif dalam mendukung rencana peningkatan usaha desa Santan Tengah. Dari kagiatan pengabdian masyarakat ini memberikan manfaat kepada pemerintah desa dan masyarakat di desa Santanh Tengah berupa kemudahan dalam merencanakan alternatif perencanan strategis peningkatan usaha desa berbasis keunggulan lokal yaitu usaha minyak kelapa dan usaha pemasokan tandan buah segar (TBS) kelapa sawit hasil produksi perkebunan masyarakat kepada perusahaan pengelolah buah sawit.
Kegiatan Pelatihan Retorika Public Speaking untuk Profesi Psikologi
Authors: Hairunnisa Hairunnisa , Nurrahim Irsalinda Wesa , Syahidah Shiba Syahidah , Rifaldi Ahmad Naufal , Al-Hadad Muhammad Naufal
Published: April 2022

Mahasiswa S1 Psikologi merupakan bagian dari masa depan bangsa yang diharapkan mampu memberikan teladan dalam kepemimpinan di masyarakat luas. Setiap prilaku dan ucapan yang disampaikan diharapkan menjadi contoh dan teladan yang baik untuk masyarakatnya. Agar hal tersebut terlaksana dengan baik maka diperlukan dan menjadi keharusan untuk dibekali keterampilan berbicara yang baik dan santun, sehingga mereka mampu menjadi tenaga-tenaga pamong yang handal, kompeten, tangguh dan professional dalam menangani permasalahan-permasalahan masyarakat dan memberikan pelayanan kepada public. Strategi yang digunakan dalam kegiatan pelatihan Public Speaking untuk profesi psikologi ini ialah menggunakan Focus Group Discussion (FGD). FGD itu sendiri ialah diskusi terfokus dari suatu grup dalam membahas suatu masalah tertentu. Diharapkan setelah ini Mahasiswa mendapatkan manfaat secara komprehensif dalam keterampilan dasar dan lanjutan untuk penerapan kepiawaian berbicara yang baik dan santun dihadapan public sehingga menjadi motivator/interest rekan sejawat di lingkungan kampus. 

 

Kata Kunci : Profesi Psikologi, Ilmu komunikasi, Public Speaking

Abstract:

Undergraduate Psychology students are part of the nation's future who are expected to be able to provide role models in leadership in the wider community. Every behavior and speech conveyed is expected to be a good example and role model for the community. In order for this to be carried out properly, it is necessary and imperative to be equipped with good and polite speaking skills, so that they are able to become reliable, competent, tough and professional civil servants in dealing with community problems and providing services to the public. The strategy used in the Public Speaking training for the psychology profession is to use a Focus Group Discussion (FGD). FGD itself is a focused discussion of a group in discussing a particular problem. It is hoped that after this students will get comprehensive benefits in basic and advanced skills for the application of good and polite speaking skills in front of the public so that it becomes a motivator / interest for colleagues in the campus environment.

 

Keyword: Profession Psychology, Communication Studies, Public Speaking
Kegiatan Pemberitaan dan Edukasi – Sosialisasi Menjaga Keseimbangan Ekosistem Sungai Karang Mumus
Authors: Ariffin Muhammad , Hairunnisa Hairunnisa , Al-Hadad S. Muhammad Naufal , Kharimah Nindiani
Published: April 2022

Sungai merupakan salah satu ekosistem pendukung kehidupan dalam masyarakat untuk beraktivitas sehari-hari seperti mandi, mencuci, dan sebagai matapencaharian. Sungai karang mumus merupakan salah satu anak sungai mahakam yang membentang sejauh 17 KM dari hulu menuju hilirnya, namun kualitas air pada sungai karang mumus terbilang cukup buruk, karena limbah rumah tangga, limbah perusahaan, serta penumpukan sendimen didasar sungai dan rumah yang dibangun di bantaran sungai mengakibatkan memburukya kualitas air disepanjang sungai karang mumus. Untuk memperbaiki kualitas air sungai, Strategi yang digunakan dalam kegiatan ini adalah melalui pemberitaan tentang keadaan Sungai Karang Mumus serta edukasi kepada masyarakat untuk menjaga ekosistem Sungai Karang Mumus. Diharapkan setelah ini Masyarakat Kota Samarinda menjaga serta merawat Sungai Karang Mumus, agar kualitas air pada sungai dapat membaik untuk digunakan dalam beraktivitas
The Practice of Flexible Inflation Targeting in India – A Preliminary Assessment
Authors: Rajadhyaksha Niranjan , Misra Prakhar
Published: April 2022

This paper examines how the new flexible inflation targeting framework has worked in practice in India, five years after it was introduced. The policy decisions taken by the Reserve Bank of India are analysed on four fronts — the trajectory of inflation, the inflation forecasting record, the voting behaviour of the monetary policy committee, and the ability to keep the weighted average call money rate within the policy corridor. These four themes represent the formal nominal anchor, the intermediate target, the central bank response function and the operating target of monetary policy. Each is a building block of the flexible inflation targeting framework. The paper then offers some suggestions on the road ahead for monetary policy practice in India, both given the experience of the past five years as well as the Covid-19 shock to the Indian economy.
Radically Networked Societies: The case of the farmers’ protests in India
Authors: Waghre Prateek
Published: April 2022

This paper analyses India’s ongoing farmer protests movement through the lens of the Radically Networked Societies (RNS) framework. Building on prior RNS-based case studies, the paper contends that this movement is marked by a combination of allied and opposing RNS groups. These RNS groups are characterised by the existence of overlapping identities operating across a mix of existing and instantaneous networks coalescing around their respective common causes of opposing the three farm laws enacted by the Union government and opposing this opposition itself. The ensuing interactions result in amplifying and sustaining adjacent and opposite RNS groups. The paper concludes that the hitherto weak bonds underlying spontaneous networked movements will be supported by hardening ties based on political identities that also transcend international boundaries. This can result in sharper responses by states which may be tempered by international pressure or scrutiny in the short term. Alternatively, an increasing number of protest movements for extended periods could lead to a flattening of responses and waning levels of attention.
Breaking the Law
Authors: Tagat Anirudh , George Nikhil , Gupta Nidhi , Kapoor Hansika
Published: April 2022

This paper adapts existing theoretical frameworks of social norms and their interactions with laws to study the case of rule violations in Indian road traffic. Specifically, we look at the case where existing laws and rules are violated with such regularity that breaking the law becomes the social norm. We investigate this framework in the case of road user behaviour in (urban) India, where road safety and traffic violations have been the focus of recent policy changes. We propose that a lack of road discipline and traffic violations have an impact on road safety, as well as on congestion. These, in turn, have implications for the economic productivity and development of a country, as well as the well-being of its citizens. Our application of the framework suggests conditions of enforcement under which such harmful social norms can be reversed. Policy interventions and scope for behaviorally-informed policies targeted at improving road user behaviour are discussed.
Advocating Credible Naval Power
Authors: Pareek Aditya
Published: April 2022

Capt. (Dr.) Hendrix’s sobering insights are the best representation of contemporary US maritime strategic thought. Seth Cropsey, on the other hand, has an entertaining set of fictional scenarios; although a bit alarmist, these ultimately convey the same message as Hendrix, that the US needs to renew its emphasis on credible naval power.
Dual Problem of FPTP Electoral Systems: Evidence from the Indian States
Authors: Jadhav Vivek
Published: April 2022

Democracy across the world has witnessed the evolution of the electoral system. First-Past-The-Post (FPTP), practiced in India has certain disadvantages in terms of disproportionate representation. This paper aims to construct the Gallagher Index, Gini Coefficient, and Generalized Entropy Index to measure and analyse the political concentration and inefficiency that characterise such disproportionate representation. The Gallagher Index measures the disproportionality between seat share and vote share; as it captures the disproportionality between votes received and seats won in the house. This can be viewed as a measure of inefficiency in representing the population, inasmuch as parties with a low vote share can have a high seat share. In other words, even though voters are not preferring the particular party or set of parties, these parties can still get enough seats to govern the particular state. Further, this paper tries to build the association between inefficient representation and concentration of power. We show that the high level of inefficiency in representation observed in the Indian State Assemblies is associated with the concentration of power at the state government level. We suggest that since FPTP in Indian democracy is associated with the dual problems of inefficiency and concentration, alternatives to FPTP should be considered.
Indian Agriculture @ 75
Authors: Juneja Ritika , Roy Ranjana , Gulati Ashok
Published: April 2022

India has experienced significant transformation in its economy since independence, especially agriculture. From a severely food-deficit nation during mid-1960s to a self-sufficient one, and becoming the largest exporter of rice and the largest producer of milk in 2020-21 is not a small achievement. Similar break-throughs have been achieved in poultry, fishery, fruits and vegetables, and cotton. All this was made possible with liberal infusion of modern technology, institutional innovations that made small holders part of this change, and enabling right incentives to cultivators. This holds lessons for many developing countries in south and south-east Asia as well as in African continent. But India still faces many challenges on food security front. Malnutrition rates amongst children remain high, and agricultural production begs the question of sustainability as water table in most parts of the country is falling rapidly. Also, the food system needs to move from ‘tonnage centric to farmer centric’ as incomes of agri-households remain pretty low, largely because of small holding sizes. It is high time that India opens up land lease markets, build efficient supply chains with Farmer Producer Organisations by infusing digital technologies to unleash next technological revolution that promotes efficiency, inclusiveness, and sustainability in agriculture through precision agriculture.
Demonetization and Policy Credibility: Does India Pass Muster?
Authors: Kohli Renu
Published: April 2022

This paper examines India's demonetization from the standpoint of policy credibility, employing the standard norms for assessing macroeconomic policies. The credibility appraisal constructs a narrative from contemporaneous economic records, computes the f iscal and quasi-f iscal bailout costs for mitigation, monetary costs of implementation, as well as effects upon the financial sector using public data and other empirical evidence. It considers counterfactual policy tools to examine if demonetization objectives could have been more effectively achieved at lesser costs. Based upon these comprehensive measures, the paper concludes that demonetization does not meet the established principles of credibility in the macroeconomic literature.
Educação sonora contextualizada com a música no ensino de ciências através de ferramentas tecnológicas e histórico-culturais
Authors: Swarowsky Rafael , Heckler Valmir , Lobo Hebert
Published: April 2022

O estudo apresenta aspectos emergentes da análise do desenvolver/praticar o tema da Educação Sonora com um grupo de professores, em processo formativo em uma disciplina de um Programa de Pós-graduação em Educação em Ciências, de uma Universidade Pública do Brasil. O estudo de natureza qualitativa, com enfoque na abordagem fenomenológica hermenêutica, assume a questão central o que se mostra de Educação Sonora com professores de Ciências em uma comunidade Online. A aula sobre a temática Música, em uma perspectiva da Educação Online, foi estruturada em um Ambiente Virtual de Aprendizagem (AVA), em que foram registradas, os materiais, atividades e as gravações em vídeo da aula para análises posteriores. A análise de dados foi desenvolvida com a Análise Textual Discursiva (ATD). Para a organização dos dados foi utilizado o software do ATLAS.TI. Como resultado do estudo apresenta-se a categoria emergente Ruídos e a Música: Um diálogo através de uma atividade experimental.
Modelo Kaizen en el sector público
Authors: Casanova-Villalba César Iván , Herrera-Sánchez Maybelline Jaqueline , Rivadeneira-Moreira Julio César , Ramos-Secaira Francisco Marcelo , Bueno-Moyano Franklin Roberto
Published: April 2022

Las instituciones del sector público deben acogerse a las necesidades emanadas por sus usuarios, por esto son controladas por diferentes entidades gubernamentales y cumplen diferentes normativas legales. Bajo este enfoque surgen diferentes metodologías para la eficiencia y eficacia, el libro responde a un modelo “Kaizen” pero bajo la metodología gubernamental de Gobierno por Resultados. El modelo presentado utiliza herramientas de calidad como identificación de las mudas que corresponden a los desperdicios, aplicación de las 5s que es una metodología aplicada a la limpieza, orden, planificación, seguridad y autodisciplina, estas dos herramientas bajo un esquema PHVA que no es más que el proceso de planificar, hacer, verificar y actuar. Para poder aplicar este modelo se debe obtener datos de los procesos y actividades, con lo cual se tiene un antecedente y poder medir el cumplimiento de los objetivos institucionales
MORPHOLOGICAL RESEARCH USAGE OF BIOPLAST - DENT IN EXPERIMENT
Authors: Nodar Sulashvili Nodar Sulashvili , Tamar Okropiridze Tamar Okropiridze
Published: April 2022

The work represents experimental and morphological studies of regeneration of damaged areas of maxillo-facial bones. Time course of healing of induced defects in the low jaw bone filled with bioplast - dent and was studied in experimental rabbits. On days 7, 14, 21 and 28 four rabbits from each group were killed and the defect investigated by X-ray and histological methods. We stained the micropreparations ith hematoxilineeosine. Bioplast - dent granulate exerted the best effect on bone repair. In experiments with bioplast - dent, bone regenerate replaced up to one half of the area of defect by day 28.
Keywords: Osteogenesis stimulation, reparative regeneration, morphological, X-ray.
THE SCIENTIFICS DISCUSSION OF WORLDWIDE CHALLENGES OF COVID-19 PANDEMIC AND GENERAL DRUG THERAPY APPROACHES TO COMBAT THE COVID-19 DISEASES
Authors: Nodar Sulashvili Nodar Sulashvili , Luiza Gabunia Luiza Gabunia , Levan Ratiani Levan Ratiani , Nana Gorgaslidze Nana Gorgaslidze , Ketevan  Ghambashidze Ketevan  Ghambashidze , Elena Varazi Elena Varazi , Natia Antia Natia Antia
Published: April 2022

A new type of coronavirus (COVID-19) SARS-CoV-2 originated in Wuhan, China and has caused a global pandemic. COVID-19 is a newly emerging infectious disease caused by SARS-CoV-2 and is known as SARS. By July 1, 2020, more than 10 million people worldwide will be infected with SARS-CoV-2. Typical manifestations of COVID-19 are fever, sore throat, fatigue, cough, and shortness of breath combined with recent exposure. Most COVID-19 patients have mild to moderate illness; however, 5 to 10% have a serious and even life-threatening illness. The death rate is around 2-3%. Therefore, there was an urgent need for a specific and effective antiviral treatment. Supportive measures such as oxygenated ventilation and fluid handling remain the standard of care today. Several clinical studies are ongoing to determine the most effective drug or combination for this disease and it is highly recommended that patients be included in ongoing studies. The safety and effectiveness of antiviral drugs could only be demonstrated in randomized clinical trials. Several active ingredients such as chloroquine, hydroxychloroquine, favipiravir, monoclonal antibodies, antisense RNA, corticosteroids, convalescent plasma and vaccines were currently being evaluated. A variety of therapeutic interventions were aimed at determining the most effective regimen. The purpose of this article is to describe the treatment strategies that have been used for patients with COVID-19 and to review all available literature.
Keywords: Worldwide, therapy, treatment, COVID-19 diseases, pandemic.
Expression of CD28 in Hepatocellular Carcinoma and Its Prognostic Value
Authors: Ran Xiaoke , Zhang Chuanlei , Wang Xinting , Zhao Qing , Zhao Qiang , Yuan Changwei , Kuang Yuhui , Chen Xiaoqi , Chen Xinju
Published: April 2022

Background: CD28 expression is correlated with malignancy development in long-term survivors after liver transplantation. Immune cell activation is mediated by the interaction of CD28 with CD4 and CD8. Objectives: In this study, we attempted to investigate the expression level and prognostic value of CD28 in hepatocellular carcinoma (HCC). Methods: A total of 54 HCC patients with complete clinical information were examined. The expression level of CD28 in HCC tissues was detected by immunohistochemistry. The correlations of CD28 expression with clinical characteristics, CD4+/CD8+ T-cells, and prognosis in HCC were analyzed. The expression profile of CD28 and survival time of HCC patients were retrieved from the TCGA database, followed by survival analysis. Results: The positive expression rate of CD28 in HCC tissues was 70.73%. The CD28 expression was significantly higher in the positive expression group (area: 659174.9 ± 670060, IOD: 123348.3 ± 106348.6) than in the negative expression group (area: 8405.7 ± 9983.3, IOD: 1959.6 ± 2117.7) (P < 0.01). The CD4+ and CD8+ cell counts were 526.13 ± 258.17 cells/µL and 383.93 ± 223.39 cells/µL, respectively. The expression level of CD28 was significantly related to the degree of differentiation and the number of CD4+ and CD8+ T-cells (P < 0.05). The survival time of patients was longer in the positive CD28 expression group than in the negative expression group. Based on the CD28 expression profiles of 406 HCC patients retrieved from the TCGA database, patients with high CD28 expression showed a better prognosis than those with low expression (P < 0.05). Conclusions: CD28 may play a vital role in the occurrence, development, and prognosis of HCC by interacting with CD4+ and CD8+ T-cells. Thus, CD28 could be suggested as the immune checkpoint target for HCC treatment.
Changes in the Prevalence of Micronutrient Deficiencies Among Under-2- and 6-Year-Old Children in Two National Surveys in Iran
Authors: Abtahi Mitra , Pouraram Hamed , Djazayery Abolghassem , Siassi Fereydoun
Published: April 2022

Background: Micronutrients, such as vitamin A, vitamin D, iron, and zinc have several useful functions in the body and are necessary for normal growth and development, especially among children. Unfortunately, recent research has showed different levels of deficiency of these two vitamins among children. Objectives: This study aimed to compare the prevalence of micronutrient deficiencies, including vitamin A, vitamin D, iron, and zinc, among under-2- and 6-year-old children in Iran in two National Integrated Micronutrient Surveys (NIMS-I, NIMS-II). Methods: In NIMS studies, sampling was done using a single-stage cluster sampling method. The country was divided into 11 study zones. Using simple random sampling, more than 4,400 individuals (about 400 samples in each zone) were included in each study (NIMS-I, NIMS-II). At least 4-mL venous blood samples were taken from all children and transferred to the central laboratory of Tehran University of Medical Sciences (TUMS) with special identification code for further analysis. Then, the levels of vitamin A, vitamin D, iron, and zinc were measured. Results: In NIMS-I, the prevalence of vitamin A deficiency among under-2-year-old children was 0.5%, which significantly increased to 18.3% in NIMS-II. Regarding vitamin D deficiency, the rate of deficiency was 3.7% in NIMS-I and 23.3% in NIMS-II, which was statistically significant. In none of the NIMS studies (I and II), vitamin A was measured in under-6-year-old children. Also, in the NIMS-I study, vitamin D was not measured among under-6-year-old children, and in NIMS-II study, the prevalence of vitamin D deficiency was 61.8%. Zinc deficiency among under-2-year-old children in both studies was nearly the same (19.1% vs. 19.4%); but in NIMS-II study, zinc deficiency among under-6-year-old children was 13.6%, which significantly decreased compared to the NIMS-I (31%). Iron deficiency status among under-2-year-old children significantly decreased from 37.8% in NIMS-I to 17.1% in NIMS-II. A significant reduction in iron deficiency status was also observed in the NIMS-II study compared to the NIMS-I in under-6-year-old children (9.9% in NIMS-II compared 18.2% in NIMS-I). Conclusions: The increase in both vitamin A and vitamin D deficiency rates in NIMS study is alarming. Due to the special roles of these two vitamins in health, special considerations and effective actions are needed in this respect. Data from two national studies indicated a decrease in the prevalence of iron deficiency in both age groups, which could be due to the successful implementation of nutritional intervention programs in Iran, such as iron supplementation and iron fortification.
Effects of Wound Fluid on Breast Cancer-derived Spheroids in a 3D Culture System: A Case Series Study
Authors: Hojat Ali , Jeibouei Shabnam , Aref Amir Reza , Kalbasi Alireza , Moghaddam Maryam , Mohammadi Farzaneh , Javadi Seyed Mohammadreza , Ajoudanian Mohammad , Sharifi Kazem , Zali Hakimeh , Akbari Mohammad Esmaeil
Published: April 2022

: Surgery is the standard treatment for breast malignancies, although local and distant relapses might occur. Previous studies have shown that surgery-induced wound fluid (WF) contains tumor-initiating and progressing factors; however, these experiments have only been performed on breast cancer cell lines. Since a cancerous tumor includes various components like malignant cells, recruited non-malignant cells and extracellular matrix, those investigations that only focused on cancer cell lines themselves are not adequate to establish WF's effects. We conducted a 3D model study where we mimicked the tumor microenvironment to re-assess previous in-vitro findings. We generated human-derived breast tumor spheroids from 23 patient specimens, dissociated and cultured them in microfluidic devices. The spheroids from each sample were treated with the patients’ WF or RPMI medium. The proportion of live and dead cells was assessed using live/dead assays and fluorescent imaging on day 6. In 22 samples, the percentage of live cells was significantly higher in the WF-treated group than in the RPMI-treated group. In one sample, we observed an opposite trend. The results were contrary in one of the samples, and we reported that case with more details. We compared the two groups using the 3D culture environment of human-derived tumor spheroids prepared from different microfluidic devices to mimic the tumor environment heterogeneity. Our findings showed that most patients with breast cancer benefit from surgical wound healing. However, removal of the surgical-induced serum may not be a method of inhibiting the tumor in all patients.
Rastafarians and the Anti-Nuclear Movement in Japan
Authors: Kamimoto Shuji ,   Academic Publishing
Published: April 2022

The study aims to explore the relationship between Rastafari and the anti-nuclear movement in Japan, following the accident at Tokyo Electrical Power Company’s (TEPCO) Fukushima Daiichi Nuclear Power Plant, an incident, which was a result of the 2011 Great East Japan Earthquake. This event revitalised the anti-nuclear movement in Japan, which included Japanese Rastas among its participants. This study focuses specifically on the case of reggae singer Sing J Roy, who participated in the anti-nuclear movement and produced a song on the theme of community development in the Wakasa region of Fukui Prefecture in 2013. In this case, it becomes clear that the intentions of the anti-nuclear movement backed by Rastafarai’s ideology are mixed with attempts to revitalise the region led by the local government and local residents in an inconspicuous way.
Applied Political Philosophy: Indira Gandhi and the Subcontinent
Authors: Duran Jane ,   Philosophy Documentation Center
Published: April 2022

More than one line of argument is adduced to buttress and support the contention that the writings of Indira Gandhi constitute a valuable political philosophy for today. Her Peoples and Problems is alluded to, and the advertence of her thought to Vedanta made clear.
Conventions and Status Functions
Authors: Jankovic Marija , Ludwig Kirk ,   Journal of Philosophy Inc.
Published: April 2022

We argue that there is a variety of convention, effective coordinating agreement, that has not been adequately identified in the literature. Its distinctive feature is that it is a structure of conditional we-intentions of parties, unlike more familiar varieties of convention, which are structures of expectations and preferences or obligations. We argue that status functions (i.e., social functions like being a pawn, a president, or a dollar bill) constitutively involve this variety of convention, and that what is special about it explains, and gives precise content to, the central feature of status functions, namely, that objects with status functions can perform their functions only insofar as they have been collectively accepted as having them.
Humanizing Students’ Information Literacy Development
Authors: Mohd Noor Norhayati
Published: April 2022

Students’ ability to search, analyse, synthesise and use information often associated with students’ cognitive ability. Such a perspective has limited the knowledge on affective domain of students’ information literacy development. The study examined the interplay of affective domain in students’ information literacy development in higher learning. The study employed a qualitative research design and involved 31 lecturers, librarians and students in a public research university. Data was collected using semi-structured interviews and analysed using qualitative data analysis approach. The study found that respect, appreciation and trust among lecturers, librarians, students, experts, and practitioners have led to collective and organised efforts of students’ information literacy development at classroom, department and university levels. The study also found that personal passion, irritation, self-esteem, patience, boredom, frustration, difficulty, and preference have somewhat influenced lecturers’, librarians’, and students’ participation and non-participation in students’ information literacy development. The study further implicated that the integration of affective domain in the planning and implementation of the learning process, outcomes and assessment of students’ information literacy development is a way forward to humanise and thus sustain the development and application of information literacy in higher learning.
Peace and Nuclear-free Advocacy Revisited: Lessons from New Zealand and Implications for Japan
Authors: Temocin Pinar , Kawano Noriyuki
Published: April 2022

Although there are multiple pathways of conditions leading to desired policy outcomes, the viability of peace and nuclear-free advocacy can be related to the convergence of a strong, diverse, and active civil society, where leadership and a responsive political environment are well-integrated. We discuss that sociopolitical mobilizations (e.g. peace and nuclear-free advocacy), active civil society, and democratic institutions are not only linked to each other but are also co-existent. In this essay, we look at the case of New Zealand (Aotearoa) with its unique nuclear-free peace movement and find some implications for contemporary Japan, which is the only country which was subjected to atomic bombing but which does not support nuclear disarmament in its official policies, despite the presence of a long-standing peace movement and substantial majorities in favor of steps like Japan signing the 2017 Treaty on the Prohibition of Nuclear Weapons (TPNW).
The Role of Nuclear Forensics for Determining the Origin of Nuclear Materials Out of Regulatory Control and Nuclear Security
Authors: Ghimire Lekhnath , Waller Edward
Published: April 2022

The international community recognizes the rise in theft and illicit trafficking of nuclear materials and radioactive sources—for malicious use and nuclear terrorism—as a serious threat. That is why a well-developed nuclear forensics capability is an integral part of a robust nuclear security program and a key element of nuclear security infrastructure. Both pre- and post-detonation nuclear forensics are vital for controlling theft and illicit trafficking of nuclear materials, as well as identifying and tracing their sources. Nuclear forensics analysis and interpretation processes for nuclear security is a systematic process that includes: (1) sample collection and categorization techniques and (2) detailed nuclear forensics analytical plans, which are a laboratory analysis of physical and chemical properties of the collected or seized nuclear and radioactive materials. Besides nuclear materials, the non-nuclear and biological materials present in seized nuclear materials can also provide important information about the source and origin of nuclear materials. Upon complete analysis of the seized materials, the data interpretation to trace the origin of the nuclear and radiological materials is one of the most critical steps to identifying the origin of the materials, which depends on the availability of similar data to compare. So, each country should have its own incident register system (IRS) and collaborate with the International Technical Working Group (ITWG), Incident and Trafficking Database (ITDB), and IAEA for data sharing and interpretation.
Prediction of Reperfusion Outcome using Platelet Indices in Primary Percutaneous Coronary Intervention- A Prospective Cohort Study
Authors: Attumalil Thomas Varghese , Chirame Sam Jacob , Radhakrishnan VV , Viswanathan K Sunitha , Koshy Alummoottil George , Gupta Nini Prabha
Published: April 2022

Introduction: Platelets play a vital role in systemic inflammation and thrombus formation in ST Elevation Myocardial Infarction (STEMI). Understanding its role has diagnostic and prognostic implications in developing therapeutic strategies. Aim: To estimate the prognostic accuracy of platelet indicesMean Platelet Volume (MPV), Platelet Distribution Width (PDW) and MPV/Platelet Count (PC) Ratio (MPV/PC ratio) on reperfusion outcome in STEMI patients. Materials and Methods: This prospective cohort study enrolled 262 subjects, who presented with acute chest pain within a window period of 12 hours, and an Electrocardiogram (ECG) suggestive of STEMI. Blood samples collected on admission were measured for MPV and PDW. The major endpoints studied were angiographic thrombus burden and in-hospital Major Adverse Cardiovascular Events (MACE). Data was summarised by Mean and SD for continuous variables, frequency and percentage for categorical variables. Results: This study demonstrated that Acute Coronary Syndrome- STEMI (ACS-STEMI) patients with larger PDW had Larger Thrombus Burden (LTB). PDW of more than 13 fL was the best cut off for predicting LTB with a sensitivity of 67.01% and a specificity of 53.23%. There was no significant difference between the means of MPV in LTB and small thrombus burden. The total in-hospital MACE at the end of one week was 20.99% (n=55/262 patients). The maximum MACE was contributed by acute heart failure (12.6%), followed by cardiac death (6.1%) and stent thrombosis (1.5%). There was a significant association between increased PDW and in-hospital MACE, mortality and acute heart failure (p-value=0.024, p-value=0.03, p-value=0.02, respectively). The best cut-off PDW value for prediction of the composite MACE endpoint was 14.7 fL with sensitivity of 75.6% and specificity of 51.4% and the area under the Receiver Operating Characteristic (ROC) curve was 0.63 (95% CI, 0.57 to 0.69). Conclusion: The study emphasises the use of platelet indices, especially PDW, as a predictor of poorer reperfusion outcomes in primary Percutaneous Coronary Intervention (PCI) as evidenced by higher MACE rates in patients with higher PDW. Hence, PDW can help in predicting the thrombus burden even before doing the angiogram and such high-risk patients could benefit from early initiation of stronger antiplatelets, Gp IIb/IIIa (Glycoprotein) antagonist drugs and thrombus aspiration techniques.