bluuebunny/crossref_metadata_2025 huggingface dataset:
Neurosonographic Classification in Premature Infants Receiving Omega-3 Supplementation Using Convolutional Neural Networks
Authors: Zivojinovic Suzana , Petrovic Savic Suzana , Prodanovic Tijana , Prodanovic Nikola , Simovic Aleksandra , Devedzic Goran , Savic Dragana
Published: June 2024

This study focuses on developing a model for the precise determination of ultrasound image density and classification using convolutional neural networks (CNNs) for rapid, timely, and accurate identification of hypoxic-ischemic encephalopathy (HIE). Image density is measured by comparing two regions of interest on ultrasound images of the choroid plexus and brain parenchyma using the Delta E CIE76 value. These regions are then combined and serve as input to the CNN model for classification. The classification results of images into three groups (Normal, Moderate, and Intensive) demonstrate high model efficiency, with an overall accuracy of 88.56%, precision of 90% for Normal, 85% for Moderate, and 88% for Intensive. The overall F-measure is 88.40%, indicating a successful combination of accuracy and completeness in classification. This study is significant as it enables rapid and accurate identification of hypoxic-ischemic encephalopathy in newborns, which is crucial for the timely implementation of appropriate therapeutic measures and improving long-term outcomes for these patients. The application of such advanced techniques allows medical personnel to manage treatment more efficiently, reducing the risk of complications and improving the quality of care for newborns with HIE.
Using Machine Learning for Non-Invasive Detection of Kidney Stones Based on Laboratory Test Results: A Case Study from a Saudi Arabian Hospital
Authors: Alghamdi Hanan , Amoudi Ghada
Published: June 2024

Kidney stone disease is a widespread urological disorder affecting millions globally. Timely diagnosis is crucial to avoid severe complications. Traditionally, renal stones are detected using computed tomography (CT), which, despite its effectiveness, is costly, resource-intensive, exposes patients to unnecessary radiation, and often results in delays due to radiology report wait times. This study presents a novel approach leveraging machine learning to detect renal stones early using routine laboratory test results. We utilized an extensive dataset comprising 2156 patient records from a Saudi Arabian hospital, featuring 15 attributes with challenges such as missing data and class imbalance. We evaluated various machine learning algorithms and imputation methods, including single and multiple imputations, as well as oversampling and undersampling techniques. Our results demonstrate that ensemble tree-based classifiers, specifically random forest (RF) and extra tree classifiers (ETree), outperform others with remarkable accuracy rates of 99%, recall rates of 98%, and F1 scores of 99% for RF, and 92% for ETree. This study underscores the potential of non-invasive, cost-effective laboratory tests for renal stone detection, promoting prompt and improved medical support.
Clinical Remission Criteria and Serum Levels of Type 2 Inflammation Mediators during 24 Weeks of Treatment with the Anti-IL-5 Drug Mepolizumab in Patients with T2-High Severe Asthma
Authors: Palacionyte Jolita , Januskevicius Andrius , Vasyle Egle , Rimkunas Airidas , Miliauskas Skaidrius , Malakauskas Kestutis
Published: June 2024

Anti-interleukin (IL) 5 is an effective treatment modality for inhibiting eosinophilic inflammation in patients with T2-high severe asthma. The aim of this study was to determine the clinical efficacy and serum levels of type 2 inflammatory mediators during 24 weeks of mepolizumab treatment in patients with T2-high severe asthma. Eighteen patients with T2-high severe asthma were enrolled in this study. All patients received 100 mg of mepolizumab subcutaneously every 4 weeks and were retested at 4, 12, and 24 weeks. A clinical examination, asthma control test (ACT), and spirometry were performed; fractional exhaled nitric oxide (FeNO) levels were evaluated; and blood samples were drawn at every visit. Type 2 inflammation mediator levels were measured using enzyme-linked immunosorbent assay (ELISA). The blood eosinophil level significantly decreased, the ACT score and FEV1 increased after 4 weeks of mepolizumab treatment with the same tendency after 12 and 24 weeks (p < 0.05), and the FeNO level did not change (p > 0.05). A total of 27.8% of patients reached clinical remission criteria after 24 weeks of mepolizumab treatment. IL-33 and eotaxin significantly increased (p < 0.05) while IL-5, IL-13, thymic stromal lymphopoietin (TSLP), soluble IL-5 receptor subunit alpha (sIL-5Rα), and soluble high-affinity immunoglobulin E receptor (sFcεRI) decreased, with the same tendency after 12 and 24 weeks (p < 0.05). The serum levels of immunoglobulin (Ig) E and IL-4 and IL-25 levels did not change during mepolizumab treatment compared to baseline (p > 0.05). In conclusion, treatment with mepolizumab over 24 weeks improved lung function and asthma control in T2-high severe asthma patients, with nearly one-third achieving clinical remission criteria, and affected the balance of type 2 inflammatory mediators.
Optimized Strategies for Managing Abdominal Hydatid Cysts and Their Complications
Authors: Mihetiu Alin , Bratu Dan , Sabau Dan , Nastase Octavian , Sandu Alexandra , Tanasescu Ciprian , Boicean Adrian , Ichim Cristian , Todor Samuel Bogdan , Serban Dragos , Hasegan Adrian
Published: June 2024

Hepatic hydatid cysts are an example of a zoonosis with global distribution, but with endemic characteristics in certain geographic areas. Known since ancient times, this parasitic infection predominantly affecting the liver and lungs remains a challenge today in terms of diagnosis and the pharmacological, radiological, endoscopic, or surgical therapy. This study analyzed the complications associated with different procedures for treating hydatid cysts in 76 patients admitted to the County Clinical Emergency Hospital of Sibiu. Complications occurred in 18 patients (23.7%), with no significant correlation to age, gender, or residency (urban or rural). Patients undergoing open surgery exhibited the highest complication rate (61.1%) compared to those treated with other procedures. The most frequent complication was biliary duct rupture, occurring in 22.7% of cases. Our findings indicate that the presence of complications significantly prolongs hospitalization time [t df (75) = 12.14, p < 0.001]. Based on these findings, we conclude that the surgical approach for hydatid cysts should be meticulously tailored to each patient’s specific circumstances to reduce the risk of complications and improve clinical outcomes.
Current Sensor Fault-Tolerant Control Strategy for Speed-Sensorless Control of Induction Motors Based on Sequential Probability Ratio Test
Authors: Zhang Feige , Gao Shesheng , Zhang Wenjuan , Li Guo , Zhang Chao
Published: June 2024

In the speed-sensorless vector control of induction motors (IMs), the speed estimation accuracy suffers from the deteriorated current measurement caused by the current sensor faults, such as open circuit in one phase, DC bias, and odd harmonics. In this paper, a novel speed estimation strategy based on the current sensor fault-tolerant control is proposed to improve the speed estimation accuracy under the current sensor faults. First, to detect the current sensor faults in real time, the sequential probability ratio test is introduced to the system by using the innovations of the extended Kalman filter (EKF). Second, to ensure speed estimation accuracy, a double-cascading second-order generalized integrator (DSOGI) is employed to reconstruct the faulty current information when a fault is identified. Finally, the reconstructed current information is fed back to the sequential probability extended Kalman filter (SPEKF), which estimates the rotor speed of the IM, and high-accuracy speed estimation under the condition of current sensor faults is achieved. The effectiveness of the proposed strategy is validated by a series of experiments, which were conducted on a 3 kW induction motor drive platform.
The Method of Elementary Solvers in SPICE
Authors: Miranda Enrique
Published: June 2024

Circuit simulators are fundamentally used for solving electric circuit problems with different degrees of complexity in which node voltages and branch currents are the unknowns. This is fully understandable since they were originally created for this specific task. However, behind the curtains, powerful simulation engines based on a variety of numerical techniques operate so as to always comply with Kirchhoff’s current and voltage laws. In this paper, it is shown how a simple circuital configuration, referred to as the elementary solver, consistent in two behavioral current sources in series, can be used to solve mathematical problems that go beyond electronics. Of course, the intention is not to substitute mathematical packages with well-proven calculus capacity but to increase the scope of circuit simulators for their application in other areas of research or simply for educational purposes. It is worth mentioning that no special programming skills are required (except a basic knowledge of the available tools and language) and, furthermore, that the user can operate exclusively in a graphical environment. It is shown, throughout a series of selected examples, how the method of elementary solvers (MES) works, providing a new and practical dimension to the applicability of circuit simulators.
Survey on Resource Allocation for Future 6G Network Architectures: Cell-Free and Radio Stripe Technologies
Authors: Conceição Filipe , Gomes Marco , Silva Vitor , Dinis Rui
Published: June 2024

Future beyond fifth-generation (B5G) and sixth-generation (6G) communication systems require a higher quality of service (QoS) along with meeting multiple objectives and traffic demands. Consequently, new multi-antenna technologies and massive multiple-input-multiple-output (mMIMO) architectures have been proposed in recent years. This paper delves into the foundational concepts that form the basis for the design of two potential future mMIMO network topologies: cell-free (CF) network and its successor, the radio stripe (RS) system. Key aspects of the mMIMO and CF network concepts are addressed, along with a practical sequential implementation based on RSs. This exploration encompasses intricate details of the channel estimation (CE) phase, as well as the uplink (UL) and downlink (DL) transmission and reception phases. We then focus on analyzing optimization concepts that underpin resource allocation (RA) algorithms, specifically those applied in UL power allocation and access point selection (APS) schemes in both CF and RS networks. This comprehensive understanding serves as a robust foundation for addressing the challenges inherent in achieving the conflicting B5G and 6G major key performance indicators (KPIs), such as enhancements on spectral efficiency (SE), power efficiency (PE), and computational complexity or load balance (LB).
A Wind Power Fluctuation Smoothing Control Strategy for Energy Storage Systems Considering the State of Charge
Authors: Peng Li , Luo Longfu , Yang Jingyu , Li Wanting
Published: June 2024

With the significant increase in the scale of energy storage configuration in wind farms, improving the smoothing capability and utilization of energy storage has become a key focus. Therefore, a wind power fluctuation smoothing control strategy is proposed for battery energy storage systems (BESSs), considering the state of charge (SOC). First, a BESS smoothing wind power fluctuation system model based on model predictive control (MPC) is constructed. The objective function aims to minimize the deviation of grid-connected power from the target power and the deviation of the BESS’s remaining capacity from the ideal value by comprehensively considering the smoothing effect and the SOC. Second, when the wind power’s grid-connected power exceeds the allowable fluctuation value, the weight coefficients in the objective function are adjusted in real time using the first layer of fuzzy control rules combined with SOC partitioning. This approach smooths wind power fluctuations while preventing overcharging and overdischarging of the BESS. When the grid-connected power is within the allowable fluctuation range, the charging and discharging power of the BESS is further refined using a second layer of fuzzy control rules. This enhances the BESS’s capability and utilization for smoothing future wind power fluctuations by preemptively charging and discharging. Finally, the proposed control strategy is simulated using MATLAB R2021b with actual operational data from a wind farm as a case study. Compared to the traditional MPC control method, the simulation results demonstrate that the proposed method effectively controls the SOC within a reasonable range, prevents the SOC from entering the dead zone, and enhances the BESS’s ability to smooth wind power fluctuations.
A Spatial Semantic Feature Extraction Method for Urban Functional Zones Based on POIs
Authors: Yang Xin , Ma Xi’ang
Published: June 2024

Accurately extracting semantic features of urban functional zones is crucial for understanding urban functional zone types and urban functional spatial structures. Points of interest provide comprehensive information for extracting the semantic features of urban functional zones. Many researchers have used topic models of natural language processing to extract the semantic features of urban functional zones from points of interest, but topic models cannot consider the spatial features of points of interest, which leads to the extracted semantic features of urban functional zones being incomplete. To consider the spatial features of points of interest when extracting semantic features of urban functional zones, this paper improves the Latent Dirichlet Allocation topic model and proposes a spatial semantic feature extraction method for urban functional zones based on points of interest. In the proposed method, an assumption (that points of interest belonging to the same semantic feature are spatially correlated) is introduced into the generation process of urban functional zones, and then, Gibbs sampling is combined to carry out the parameter inference process. We apply the proposed method to a simulated dataset and the point of interest dataset for Chaoyang District, Beijing, and compare the semantic features extracted by the proposed method with those extracted by the Latent Dirichlet Allocation. The results show that the proposed method sufficiently considers the spatial features of points of interest and has a higher capability of extracting the semantic features of urban functional zones than the Latent Dirichlet Allocation.
The Complex Immunological Alterations in Patients with Type 2 Diabetes Mellitus on Hemodialysis
Authors: Trandafir Maria-Florina , Savu Octavian Ionel , Gheorghiu Mihaela
Published: June 2024

It is widely known that diabetes mellitus negatively impacts both the innate immunity (the inflammatory response) and the acquired immunity (the humoral and cellular immune responses). Many patients with diabetes go on to develop chronic kidney disease, which will necessitate hemodialysis. In turn, long-term chronic hemodialysis generates an additional chronic inflammatory response and impairs acquired immunity. The purpose of this paper is to outline and compare the mechanisms that are the basis of the constant aggression towards self-components that affects patients with diabetes on hemodialysis, in order to find possible new therapeutic ways to improve the functionality of the immune system. Our study will take a detailed look at the mechanisms of endothelial alteration in diabetes and hemodialysis, at the mechanisms of inflammatory generation and signaling at different levels and also at the mechanisms of inflammation-induced insulin resistance. It will also discuss the alterations in leukocyte chemotaxis, antigen recognition and the dysfunctionalities in neutrophils and macrophages. Regarding acquired immunity, we will outline the behavioral alterations of T and B lymphocytes induced by diabetes mellitus and chronic hemodialysis.
Does Timepoint of Surgical Procedure Affect the Outcome in Simultaneous Pancreas–Kidney Transplantation? A Retrospective Single-Center Analysis over 20 Years
Authors: Hau Hans Michael , Jahn Nora , Vlachos Christos , Eichler Tim , Lederer Andri , Geisler Antonia , Scheuermann Uwe , Seehofer Daniel , Köppen Sylvia , Laudi Sven , Sucher Robert , Rademacher Sebastian
Published: June 2024

Background: Sleep deprivation and disturbances in circadian rhythms may hinder surgical performance and decision-making capabilities. Solid organ transplantations, which are technically demanding and often begin at uncertain times, frequently during nighttime hours, are particularly susceptible to these effects. This study aimed to assess how transplant operations conducted during daytime versus nighttime influence both patient and graft outcomes and function. Methods: simultaneous pancreas–kidney transplants (SPKTs) conducted at the University Hospital of Leipzig from 1998 to 2018 were reviewed retrospectively. The transplants were categorized based on whether they began during daytime hours (8 a.m. to 6 p.m.) or nighttime hours (6 p.m. to 8 a.m.). We analyzed the demographics of both donors and recipients, as well as primary outcomes, which included surgical complications, patient survival, and graft longevity. Results: In this research involving 105 patients, 43 SPKTs, accounting for 41%, took place in the daytime, while 62 transplants (59%) occurred at night. The characteristics of both donors and recipients were similar across the two groups. Further, the rate of (surgical) pancreas graft-related complications and reoperations (daytime 39.5% versus nighttime 33.9%; p = 0.552) were also not statistically significant between both groups. In this study, the five-year survival rate for patients was comparable for both daytime and nighttime surgeries, with 85.2% for daytime and 86% for nighttime procedures (p = 0.816). Similarly, the survival rates for pancreas grafts were 75% for daytime and 77% for nighttime operations (p = 0.912), and for kidney grafts, 76% during the day compared to 80% at night (p = 0.740), indicating no significant statistical difference between the two time periods. In a multivariable model, recipient BMI > 30 kg/m2, donor age, donor BMI, and cold ischemia time > 15 h were independent predictors for increased risk of (surgical) pancreas graft-related complications, whereas the timepoint of SPKT (daytime versus nighttime) did not have an impact. Conclusions: The findings from our retrospective analysis at a big single German transplant center indicate that SPKT is a reliable procedure, regardless of the start time. Additionally, our data revealed that patients undergoing nighttime transplants have no greater risk of surgical complications or inferior results concerning long-term survival of the patient and graft. However, due to the small number of cases evaluated, further studies are required to confirm these results.
Comprehensive GC-MS Measurement of Amino Acids, Metabolites, and Malondialdehyde in Metformin-Associated Lactic Acidosis at Admission and during Renal Replacement Treatment
Authors: Posma Rene A. , Bakker Stephan J. L. , Nijsten Maarten W. , Touw Daan J. , Tsikas Dimitrios
Published: June 2024

Metformin is the most widely used drug in type 2 diabetes. Regular metformin use has been associated with changes in concentrations of amino acids. In the present study, we used valid stable-isotope labeled GC-MS methods to measure amino acids and metabolites, including creatinine as well as malondialdehyde (MDA), as an oxidative stress biomarker in plasma, urine, and dialysate samples in a patient at admission to the intensive care unit and during renal replacement treatment because of metformin-associated lactic acidosis (MALA, 21 mM lactate, 175 µM metformin). GC-MS revealed lower concentrations of amino acids in plasma, normal concentrations of the nitric oxide (NO) metabolites nitrite and nitrate, and normal concentrations of MDA. Renal tubular reabsorption rates were altered on admission. The patient received renal replacement therapy over 50 to 70 h of normalized plasma amino acid concentrations and their tubular reabsorption, as well as the tubular reabsorption of nitrite and nitrate. This study indicates that GC-MS is a versatile analytical tool to measure different classes of physiological inorganic and organic substances in complex biological samples in clinical settings such as MALA.
Return to Sports and Activities after Arthroscopic Treatments for Rotator Cuff Lesions in Young Patients Less Than 45-Years-Old: A Systematic Review
Authors: Moussa Mohamad K. , Lang Elena , Gerometta Antoine , Karam Karam , Chelli Mickael , Grimaud Olivier , Lefèvre Nicolas , Bou Raad Ryan , Bohu Yoann , Khiami Frédéric , Khalaf Zeinab , Abadie Pierre , Hardy Alexandre
Published: June 2024

Background: To evaluate the outcomes of arthroscopic treatment of rotator cuff tear (RCT) in individuals under 45 years, focusing on their ability to return to sports (RTS) and work, along with different patient-reported outcomes (PROMs). Methods: Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, this systematic review encompassed articles that studied the outcomes of arthroscopic treatment of RCT in the young population (those under 45 years old). The literature search was conducted in PubMed/Medline and EMBASE until 21 May 2024. The primary outcome was the RTS, with secondary outcomes including the return to work and various PROMs. These PROMs included the American Shoulder and Elbow Surgeons (ASES) score and 10 other PROMs. Results: Out of 6267 articles, 15 met the inclusion criteria, involving 659 patients, predominantly male athletes with a weighted mean age of 28.3 years. The RCT etiology (14 studies) was primarily traumatic (72.3%), followed by chronic microtrauma in overhead athletes (16.8%) and non-traumatic (10.9%). The RTS rate (12 studies) varied between 47% and 100%, with a cumulative rate of 75.2%. The cumulative rate of return to the same or higher RTS level (11 studies) was 56.1%. Excluding non-athletes and patients treated with debridement, the RTS rates increased to 79.8% (143/179) overall, with a 61% (108/177) rate of returning to the same or higher level. The return to work (3 studies) was successful in 90.6% of cases. Postoperative ASES scores (5 studies) improved markedly to a weighted post-operative mean of 75.6, with similar positive trends across other PROMs. Conclusions: Young adults undergoing arthroscopic RCT repair typically experience a 75% RTS rate at any level, and 56.1% RTS at the same level. Excluding non-athletes and debridement patients, RTS rates rise to 79.8% (143/179), with 61% (108/177) achieving the same or higher level. Level of evidence: IV, systematic review including case series.
Research on Torque Performance of Marine Hybrid Excitation Synchronous Motors Based on PSO Optimization of Magnetic Permeability Structure
Authors: Yang Qingliang , Zhang Wendong , Zhao Chaohui
Published: June 2024

The rotor magnetic shunt structure hybrid excitation synchronous motor (RMS-HESM) has been widely used in marine propulsion due to its advantages of low loss and high efficiency. The objective of this paper is to improve the output torque capability of the hybrid excitation motor with a rotor magnetic shunt structure by conducting a multi-objective optimization design for the magnetic permeability structure. The first step involved establishing a mathematical analytical model of average torque and torque ripple based on the fundamental principle of motor magnetization. Next, the parameters of the magnetic permeability structure were designed and analyzed using the finite element simulation method. The impact of the variations in the parameters of the magnetic permeability structure on motor torque and no−load back electromotive force was examined. Additionally, a sensitivity analysis was performed on the design variables of the magnetic permeability structure, leading to the determination of optimization parameters based on the obtained results. The adaptive inertia weight-based particle swarm algorithm (PSO) was employed to conduct a multi-objective optimization design analysis. A comparative analysis on the average torque, torque ripple, and no−load back electromotive force of the motor before and after optimization was performed using the Maxwell and Workbench and Optislong joint simulation tools. This enhancement significantly improves the torque performance of the marine motor while simultaneously optimizing the no−load back electromotive force.
Enhancing Transforaminal Full Endoscopic Discectomy: Efficacy of the Hand Down Outside-In (HDOI) Technique
Authors: Yamaguchi Yushi , Ono Koichiro , Fukuhara Daisuke , Dezawa Akira , Majima Tokifumi
Published: June 2024

Endoscopic lumbar discectomy (ELD) is a key advancement in minimally invasive spinal surgery, particularly for lumbar disc herniation. Interlaminar endoscopic lumbar discectomy (IELD) and transforaminal endoscopic lumbar discectomy (TELD) are the two major methods used for FED. TELD, while less familiar to spine surgeons inexperienced in endoscopic surgery, presents challenges in visualizing the dura mater, a crucial aspect for reducing surgical complications. The hand down outside-in (HDOI) technique introduced by Dezawa enhances this visualization by positioning the cannula tip dorsally on the intervertebral disc and maneuvering it between the dura mater and disc to the spinal canal’s midpoint. The cannula is then flipped to directly visualize the dura mater, enabling safe removal of the prolapsed disc material. A comparative study involving 20 patients treated from April 2020 to April 2022 examined the efficacy of the HDOI technique against conventional TELD. Each group, comprising ten patients, underwent ELD for lumbar disc herniation. While both groups showed similar improvements in clinical outcomes, as assessed using the Japanese Orthopedic Association (JOA) score and visual analogue scale (VAS) for pain, the HDOI group exhibited a 100% success rate for dura mater visualization, and this rate is significantly higher than the 60% observed in the conventional TELD group. Additionally, the time required for dura mater visualization was notably shorter for the HDOI technique. These results indicate that the HDOI technique not only enhances the safety and efficacy of TELD but may also encourage its wider use in clinical settings.
Evaluation of Localized Spallation of TBCs via a Combination of Conjugate Heat Transfer Numerical and Experimental Analysis
Authors: Sun Fan , Jiang Peng , Zhang Jianpu , Chen Yiwen , Li Dingjun
Published: June 2024

To fully realize the potential application of spalled thermal barrier coating systems (TBCs) in gas turbine blades, it is essential to evaluate the service behavior of TBCs and the critical spallation size for safety servicing. For this purpose, the evaluation of the localized spallation of TBCs under high-temperature gas was investigated experimentally and numerically. Thermal insulation experiments and a conjugate heat transfer numerical algorithm were used to clarify the over-temperature phenomenon, temperature distributions, the relevant flow characteristics of the high-temperature gas in the localized spallation region of TBCs, and the influencing mechanisms that consider the spallation width were identified. The results suggested that when the spallation width was less than 10 μm, the temperature in the TBCs did not change due to the weak impression of gas. When the spallation width exceeded the security coefficient of about 3 mm, the TBCs were difficult to service safely due to the impact of high-temperature gas. Furthermore, the concept of an over-temperature coefficient was proposed to describe the over-temperature damage and a nonlinear fitting equation was obtained to reveal and predict the evolution of the over-temperature coefficient. The over-temperature coefficient may serve as a valuable metric in determining the performance degradation of TBCs.
Pressureless Immersion of Epoxy Resin-Filled Cracks in Faulted Rock Materials
Authors: Yu Kui , She Yong , Chen Jibing , Cai Xionghui , Wu Yiping
Published: June 2024

Epoxy resin, known for its excellent corrosion resistance, water resistance, and high-temperature resistance, is extensively utilized in construction and water-related projects. Within water conservancy projects, natural factors such as water impact and weathering often result in cracks within rock formations. Consequently, the application of epoxy resin materials for repair and reinforcement has emerged as a common solution. This research investigates the impact of five epoxy grouting materials, YDS (100:6.4), RH-1 (6.1:1), PSI (9:1), TK (100:8), and HK-G (5:1), on the repair and reinforcement of faulted rock at the Yebatan Hydropower Station. Penetration experiments were conducted on rock samples, and the strength of the epoxy grout samples was tested under ambient conditions of 20 °C, 15 °C, and 0 °C. The experimental results indicate that all five epoxy grout materials successfully penetrated the faulted rock samples. Among them, the PSI (9:1) epoxy grouting material exhibited the most exceptional reinforcing effect across different temperatures, with grouting samples demonstrating strengths in the range of 20 to 25 MPa. This paper confirms that epoxy resin effectively repairs and reinforces rock structures, thereby enhancing the safety and durability of water conservancy projects.
Microwave De-Icing Efficiency Improvement of Asphalt Mixture with Structural Layer Optimization and Heat-Resistance Design
Authors: Zhang Haibao , Zhou Xiaowei , Guo Haoyan , Zhang Ting , Zhao Xin , Wang Zhenjun
Published: June 2024

The application of microwave de-icing technology in road engineering is constrained by its low energy utilization rate, which can be attributed to low heat production rates and ineffective heat dissipation to the underlying pavement. In this work, asphalt mixtures are designed as an upper layer (heating layer) and a lower layer (thermal-resistance layer). Magnetite slag was selected as a microwave-sensitive source for generating heat, and expanded perlite powder was incorporated into the lower layer as a thermal resistance material. Structural layer optimization and thermal-resistance layer design of the asphalt mixture were carried out by changing the thickness of the upper and lower layers to further improve the heat production rates. The design effectiveness is comprehensively evaluated by factors such as the changing law of the average surface temperature of mixtures, ice-melting time, and cost-effectiveness analyses. The results show that EP possesses better thermal stability, lower microwave energy conversion ability and more excellent heat-resistance potential compared with mineral powder. The heat-resistance layer with EP can prevent heat from being conducted to the lower layer and promote it to concentrate on the specimen surface, which can endow the microwave heating efficiency of specimens to be further improved by up to 26.97% and the de-icing time reduced by 10%, ascribed to the heat-resistance design. Furthermore, the collaborative design of the structural layer optimization and heat-resistance layer can increase energy utilization efficiency and save microwave-absorbing materials while ensuring excellent microwave de-icing efficiency.
Emerging Trends in Nanomedicine: Carbon-Based Nanomaterials for Healthcare
Authors: Parvin Nargish , Kumar Vineet , Joo Sang Woo , Mandal Tapas Kumar
Published: June 2024

Carbon-based nanomaterials, such as carbon quantum dots (CQDs) and carbon 2D nanosheets (graphene, graphene oxide, and graphdiyne), have shown remarkable potential in various biological applications. CQDs offer tunable photoluminescence and excellent biocompatibility, making them suitable for bioimaging, drug delivery, biosensing, and photodynamic therapy. Additionally, CQDs’ unique properties enable bioimaging-guided therapy and targeted imaging of biomolecules. On the other hand, carbon 2D nanosheets exhibit exceptional physicochemical attributes, with graphene excelling in biosensing and bioimaging, also in drug delivery and antimicrobial applications, and graphdiyne in tissue engineering. Their properties, such as tunable porosity and high surface area, contribute to controlled drug release and enhanced tissue regeneration. However, challenges, including long-term biocompatibility and large-scale synthesis, necessitate further research. Potential future directions encompass theranostics, immunomodulation, neural interfaces, bioelectronic medicine, and expanding bioimaging capabilities. In summary, both CQDs and carbon 2D nanosheets hold promise to revolutionize biomedical sciences, offering innovative solutions and improved therapies in diverse biological contexts. Addressing current challenges will unlock their full potential and can shape the future of medicine and biotechnology.
A Comparison of Common Quantum Dot Alternatives to Cadmium-Based Quantum Dots on the Basis of Liver Cytotoxicity
Authors: Harris Seth , Kim Kyoungtae
Published: June 2024

Fluorescent nanoparticles known as quantum dots (QDs) have unique properties that make them useful in biomedicine. Specifically, CdSe/ZnS QDs, while good at fluorescing, show toxicity. Due to this, safer alternatives have been developed. This study uses a tetrazolium dye (XTT) viability assay, reactive oxygen species (ROS) fluorescent imaging, and apoptosis to investigate the effect of QD alternatives InP/ZnS, CuInS2/ZnS, and nitrogen-doped carbon dots (NCDs) in liver cells. The liver is a possible destination for the accumulation of QDs, making it an appropriate model for testing. A cancerous liver cell line known as HepG2 and an immortalized liver cell line known as THLE-2 were used. At a nanomolar range of 10–150, HepG2 cells demonstrated no reduced cell viability after 24 h. The XTT viability assay demonstrated that CdSe/ZnS and CuInS2/ZnS show reduced cell viability in THLE-2 cells with concentrations between 50 and 150 nM. Furthermore, CdSe/ZnS- and CuInS2/ZnS-treated THLE-2 cells generated ROS as early as 6 h after treatment and elevated apoptosis after 24 h. To further corroborate our results, apoptosis assays revealed an increased percentage of cells in the early stages of apoptosis for CdSe/ZnS-treated (52%) and CuInS2/ZnS-treated (38%) THLE-2. RNA transcriptomics revealed heavy downregulation of cell adhesion pathways such as wnt, cadherin, and integrin in all QDs except NCDs. In conclusion, NCDs show the least toxicity toward these two liver cell lines. While demonstrating less toxicity than CdSe/ZnS, the metallic QDs (InP/ZnS and CuInS2/ZnS) still demonstrate potential concerns in liver cells. This study serves to explore the toxicity of QD alternatives and better understand their cellular interactions.
Response to Climate Change and GAP Analysis of Thuja koraiensis Nakai
Authors: Yang Xiuhua , Li Xiaoyu , Cui Jiaqi , Liu Ruiqi , Li Jitong , Yang Chengjun
Published: June 2024

Due to global warming and increased human activity, the wild population of Thuja koraiensis Nakai (T. koraiensis) has dropped, placing it in danger. An understanding of the response of T. koraiensis to climate change and the determination of priority conservation areas are tremendously critical for proper conservation. Using sixty-nine T. koraiensis distribution points and seven environmental factors, the Maxent model was used to predict potentially suitable areas and spatial variation patterns of T. koraiensis and the Marxan conservation planning model was used to evaluate conservation gap areas. Research shows that the dominant environmental factors affecting the distribution of potentially suitable areas for T. koraiensis included elevation, precipitation of the driest month, isothermality and precipitation of the wettest quarter. Under the current climatic conditions, highly suitable areas for T. koraiensis are mainly distributed in the Changbai Mountains within Samjiyon County and Baishan City, the Hamgyong Mountains within the western part of Hamgyong-Bukto Province, and the T’aeback-Sanmaek Mountains within Gangwon-do, Kumgangsan Special Administrative Region and Kangwon-do. Under future climate conditions, suitable areas for T. koraiensis show a decreasing trend, and the suitable area will be reduced to higher elevations, and the Hamgyong Mountains may become a refuge. Based on GAP analysis, 69.69% of the priority conservation areas of T. koraiensis are located outside of the nature reserve, and these conservation gap areas are primarily in the southern part of the Changbai Mountains and Kangwon-do.
Short-Term Responses of Alpine Vegetation to the Removal of Dominant versus Sparse Species
Authors: Wang Weichao , Li Wei
Published: June 2024

The mass ratio hypothesis posits that ecosystem functions are predominantly influenced by the dominant species. However, it remains unclear whether a species must be abundant to exert functional dominance. We conducted a removal experiment in an alpine grassland near Pudacuo National Park, Yunnan, China, to assess the community and ecosystem impacts of the removed species. We implemented four treatments as follows: exclusive removal of the most abundant species (Blysmus sinocompressus), exclusive removal of a sparse species with high individual biomass (Primula secundiflora), simultaneous removal of both species, and a control with no removals. Results showed that removing B. sinocompressus significantly reduced biomass production, supporting the mass ratio hypothesis, while removal of P. secundiflora had negligible effects. B. sinocompressus removal positively impacted community metrics like coverage, species evenness, and the Shannon diversity index, but not species richness, likely due to its spatial dominance. Conversely, P. secundiflora removal had minimal community impact, probably due to its limited influence on nearby species. This study underscores the proportionate roles of the dominant species in alpine grasslands, emphasizing that their community and ecosystem impacts are proportional to their abundance.
Investigating and Annotating the Human Peptidome Profile from Urine under Normal Physiological Conditions
Authors: Elguoshy Amr , Yamamoto Keiko , Hirao Yoshitoshi , Uchimoto Tomohiro , Yanagita Kengo , Yamamoto Tadashi
Published: June 2024

Examining the composition of the typical urinary peptidome and identifying the enzymes responsible for its formation holds significant importance, as it mirrors the normal physiological state of the human body. Any deviation from this normal profile could serve as an indicator of pathological processes occurring in vivo. Consequently, this study focuses on characterizing the normal urinary peptidome and investigating the various catalytic enzymes that are involved in generating these native peptides in urine. Our findings reveal that 1503 endogenous peptides, corresponding to 436 precursor proteins, were consistently identified robustly in at least 10 samples out of a total of 19 samples. Notably, the liver and kidneys exhibited the highest number of tissue-enriched or enhanced genes in the analyzed urinary peptidome. Furthermore, among the catalytic types, CTSD (cathepsin D) and MMP2 (matrix metalloproteinase-2) emerged as the most prominent peptidases in the aspartic and metallopeptidases categories, respectively. A comparison of our dataset with two of the most comprehensive urine peptidome datasets to date indicates a consistent relative abundance of core endogenous peptides for different proteins across all three datasets. These findings can serve as a foundational reference for the discovery of biomarkers in various human diseases.
Lake and Atmospheric Heatwaves Caused by Extreme Dust Intrusion in Freshwater Lake Kinneret in the Eastern Mediterranean
Authors: Kishcha Pavel , Lechinsky Yury , Starobinets Boris
Published: June 2024

The role of dust intrusions in the formation of lake heatwaves has not yet been discussed in previous publications. We investigated a lake heatwave (LHW) and an atmospheric heatwave (AHW) in the freshwater Lake Kinneret in the Eastern Mediterranean: these were caused by an extreme dust intrusion that lasted for a 10-day period (7–17 September 2015). The AHW and LHW were defined as periods of abnormally high air temperature (Tair) and lake surface water temperature (SWT) compared to their 90th percentile thresholds in September. In the daytime, the maximal intensities of AHW and LHW reached 3 °C and 2 °C, respectively. This was despite the pronounced drop in solar radiation due to the dust radiative effect. The satellite SWT retrievals were incapable of representing the abnormally high SWT in the presence of the extreme dust intrusion. Both METEOSAT and MODIS-Terra showed a sharp decrease in the SWT compared to the actual SWT: up to 10 °C in the daytime and up to 15 °C in the nighttime. Such a significant underestimation of the actual SWT in the presence of a dust intrusion should be considered when using satellite data to analyze heatwaves. In the absence of moisture advection, the AHW and LHW were accompanied by an increase of up to 30% in absolute humidity (ρv) over the lake. Being a powerful greenhouse gas, water vapor (characterized by an increased ρv) absorbed most of both the upwelling and downwelling longwave thermal radiation, heating the near-ground atmospheric layer (which is in direct contact with the lake water surface), in the daytime and nighttime. In the nighttime, the maximal intensity of the AHW and LHW reached 4 °C and 3 °C, respectively. Because of the observed steadily increasing dust pollution over the Eastern Mediterranean during the past several decades, we anticipate that dust-related lake heatwaves will intensify adverse effects on aquatic ecosystems such as reducing fishery resources and increasing harmful cyanobacteria blooms.
Fast and Reliable Network RTK Positioning Based on Multi-Frequency Sequential Ambiguity Resolution under Significant Atmospheric Biases
Authors: Liu Hao , Zhang Ziteng , Sheng Chuanzhen , Yu Baoguo , Gao Wang , Meng Xiaolin
Published: June 2024

The positioning performance of the Global Navigation Satellite System (GNSS) network real-time kinematic (NRTK) depends on regional atmospheric error modeling. Under normal atmospheric conditions, NRTK positioning provides high accuracy and rapid initialization. However, fluctuations in atmospheric conditions can lead to poor atmospheric error modeling, resulting in significant atmospheric biases that affect the positioning accuracy, initialization speed, and reliability of NRTK positioning. Consequently, this decreases the efficiency of NRTK operations. In response to these challenges, this paper proposes a fast and reliable NRTK positioning method based on sequential ambiguity resolution (SAR) of multi-frequency combined observations. This method processes observations from extra-wide-lane (EWL), wide-lane (WL), and narrow-lane (NL) measurements; performs sequential AR using the LAMBDA algorithm; and subsequently constrains other parameters using fixed ambiguities. Ultimately, this method achieves high precision, rapid initialization, and reliable positioning. Experimental analysis was conducted using Continuous Operating Reference Station (CORS) data, with baseline lengths ranging from 88 km to 110 km. The results showed that the proposed algorithm offers positioning accuracy comparable to conventional algorithms in conventional NRTK positioning and has higher fixed rate and positioning accuracy in single-epoch positioning. On two datasets, the proposed algorithm demonstrated over 30% improvement in time to first fix (TTFF) compared to conventional algorithms. It provides higher precision in suboptimal positioning solutions when conventional NRTK algorithms fail to achieve fixed solutions during the initialization phase. These experiments highlight the advantages of the proposed algorithm in terms of initialization speed and positioning reliability.
Fitting the Crab Supernova with a Gamma-Ray Burst
Authors: Ruffini Remo , Sigismondi Costantino
Published: June 2024

Here, we reconsider the historical data, assuming a gamma-ray burst (GRB) as its source. A Supernova correlated with the GRB explains well the fading time observed by the ancient Chinese astronomers in the daytime and the nighttime, while the GRB power law explains the present X-rays and GeV emission of the Crab. On the grounds of a recent understanding of the first episode of binary-driven hypernova GRB (BDHN GRB) in terms of the collapse of a ten solar masses core, we propose the possible identification of the real Supernova event at an earlier time than Chinese chronicles. This work allows a new understanding of the significance of historical astronomical observations, including a fireball due to gamma-ray air shower observation and a plague of acute radiation syndrome, documented with several thousands of victims in the Eurasian area (Egypt, Iraq, and Syria).
La legalización de la eutanasia en el Ecuador, desafíos desde una perspectiva comparada
Authors: Armijos Armijos Jhovanna Mirlay , Maldonado Ruiz Luis Mauricio
Published: June 2024

La investigación aborda cuestiones esenciales frente a la búsqueda de la despenalización de la eutanasia, que se espera sirva como fuente investigativa para su implementación en el marco jurídico en el Ecuador y no simplemente como precedente jurisprudencial. La Constitución tiene los elementos necesarios  para reconocer una muerte digna como un derecho por ser un Estado Constitucional de Derechos y de Justicia, para ello, la metodología empleada en esta investigación es el método del derecho comparado externo porque permite comparar ordenamientos jurídicos extranjeros con el objetivo de destacar las semejanzas de cada uno de ellos y verificar que la legalización de la eutanasia no es un problema jurídico sino que ayuda para mantenernos en la línea de la protección de derechos humanos, por ello para su análisis hemos considerado comparar los ordenamientos jurídicos de España, Colombia, Holanda, Bélgica y el Estado de Oregón, ya que han sido pioneros en la lucha del reconocimiento a una muerte digna pese a poseer culturas jurídicas diferentes. En resumen, todo esto nos proporciona una visión valiosa para explorar este tema complejo con la finalidad de darle proponer una solución que contribuya en garantizar los derechos individuales desde la toma de decisiones en Ecuador.
dificuldades de adaptação das crianças ao ingressarem no ambiente escolar
Authors: Dos Santos Vandressa , Souza de Alencar Edvonete
Published: June 2024

O presente artigo objetiva analisar as dificuldades que as crianças na Educação Infantil têm de se adaptar a novos ambientes longe de seus familiares, investigar o processo de ingresso das crianças na escola e as características relevantes referentes à dificuldade de adaptação. Para tal, apontamos os desafios e os avanços em busca da conquista de um atendimento educacional de qualidade e identificamos algumas das dificuldades e consequências do processo de adaptação das crianças que estão ingressando a educação infantil e o ensino fundamental. Na investigação, usamos a metodologia bibliográfica. Organizamos as análises em quatro categorias: o brincar – que facilita a interação e adaptação dos sujeitos no acesso ao novo; o processo de leitura e aprendizagem – que é essencial no âmbito escolar; as emoções – um dos registros primordiais da subjetividade humana; e a família – que deve se manter em diálogo constante com a instituição. Tais categorias promovem reflexões sobre as dificuldades de adaptação das crianças no ambiente escolar.