bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnosis Delay and Factors Associated with Delay Among Tuberculosis Patients in Mombasa County, Kenya
Authors: Limo Joshua , Onyango Rosebella
Published: December 2022

Background: Tuberculosis (TB) transmissions most occur between the onset of symptoms and initiation of treatment. Early identification of cases and commencement of treatment is an effective method to control the spread of TB, but lack of clear understanding on the extent of TB diagnosis delay and factors contributing to delay continue to derail progress in combating the disease. The current agenda in global TB control is to develop better and faster tools for diagnosing TB once a symptomatic patient is found or presents to the health care system, and to provide appropriate therapy [1]. The purpose of this study was to determine the extent of diagnosis delay and factors associated with delay among tuberculosis patients in one of the high TB burdened county in Kenya (Mombasa). Calculating a reliable estimate of the TB diagnosis delay and identifying the factors affecting TB diagnostic delay provides insights into better TB management. Method: Analytic cross-sectional survey of 302 TB patients on intensive phase of treatment was carried out to determine the diagnostic delay period among tuberculosis patients. Data collected using a semi- structured questionnaire were analyzed using SPSS and Microsoft excel. The mean patient delay and associations between length of patient delay and the various independent variables was determined. Multiple logistic regression was performed to determine the factors independently associated with patient delay.
Results: The mean patient delay was 47 days; 34 days patient delay and 13 days health system delay. Patient with extra pulmonary tuberculosis (EPTB) took long to seek medical attention (average of 81 days), while those with pulmonary positive (PTB+) sought medical attention early (average of 22 days). Patients who had loss of weight as their first symptom took average of 62 days before seeking medical attention, while patients who had hemoptysis sought attention early within 14 days. 43% of the patients sought medical care at chemists/pharmacies as their first point of care. Long delay was associated with low TB awareness; 84.2% of the patients delayed due to either stigma/fear and lack of adequate knowledge on TB, 12.3% delayed due to economic constraints. Distance to the health facilities was not associated with diagnostic delay.
Conclusions: The findings of this study underscore the need for TB stakeholders to improve the quality of TB awareness in the community; educational campaigns should go beyond providing general information about TB to emphasize on embracing early seeking of care and prevention of transmission through early diagnosis and treatment.
Boiling point estimation of 1-butanol and nitromethane by the viscosity- temperature dependence study of corresponding binary fluid systems
Authors: Kouissi T. , Salhi H. , Dallel M. , Messaâdi A. , Akhtar S. , Ouerfelli N. , Toumi A.
Published: December 2022

Calculation of excess quantities in 1-butanol + nitromethane binary mixture (from 303.15 to 323.15) K from experimental shear viscosity and density values were depicted in the previous work. Investigations of these experimental values to test correlation quality of various equations and their corresponding relative functions were also reported. Taking the quasi-equality between the enthalpy of activation of viscous flow ΔH* and the molar activation energy Ea into account, we can define partial activation energy Ea1 and Ea2 for 1-butanol with nitromethane respectively together with their individual contribution separately. Correlation between Arrhenius parameters brings fourth interesting Arrhenius absolute temperature in comparison with the absolute temperature of vaporization in the fluid vapor equilibrium, and the limited corresponding partial molar quantities that can allow us to anticipate the value of the boiling points of the pure constituents. New empirical equations to indicate the boiling absolute temperature are suggested.
The validation and refinement of a Work Readiness Scale for graduate Allied Health Professionals
Authors: Lawton Vidya , Ilhan Emre , Pacey Verity , Jones Taryn M , Walker Arlene , Dean Catherine M
Published: December 2022

The transition for allied health graduates from university to the workforce has been perceived to be difficult and overwhelming, leading to early attrition within healthcare professions. Work readiness is a crucial aspect of successful transition to the workforce, however the elements of work readiness are not clearly defined. The 62-item Work Readiness scale for Allied Health Professionals (WRS-AH), based on a Work Readiness scale for a generic population of graduates, has yet to be validated. The aim of this study was to validate and refine the WRS-AH and compare the results to the original four factor construct. Participants were 245 Australian allied health professional graduates who completed the WRS-AH. An exploratory factor analysis supported a four-factor solution with domains (interpersonal capabilities, practical wisdom, personal attributes, and organisational acumen) similar to the original WRS. The final WRS-AH had 32 items, demonstrated good reliability, and explained 38% of the total variance. Using the refined scale, on average, the Australian allied health graduates reported an overall work readiness score of 80% (SD 8) with the scores highest for practical wisdom (Mean 90%, SD 8) and lowest for personal attributes (Mean 65%, SD 14). This study supports a valid and reliable scale to measure the perceived work readiness of allied health graduates as they transition from university to the workforce. The WRS-AH confirms that work readiness is multi-dimensional and may provide a more targeted approach to interventions to improve work readiness in future allied health professional graduates.
PCMT1 has Potential Prognostic Value and Promotes Cell Growth and Motility in Breast Cancer
Authors: Lin Yi-Wei , Wu Fang-Cai , Zhuang Yi-Xuan , Chu Ling-Yu , Ding Tian-Yan , Qu Qi-Qi , Li Xin-Hao , Cui Yu-Kun , Hong Chao-Qun
Published: December 2022

Breast cancer (BC) is one of the frequently diagnosed cancers, and the leading cause of cancer-related death among women worldwide. The roles of protein L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1) in human cancer have been exploring, but the clinical significance and biological function of PCMT1 in BC are not yet clear. In this study, based on the TCGA-BRCA data set, the results showed that high expression of PCMT1 gene was significantly correlated with shorter overall survival (OS), disease specific survival (DSS) and progress free suvival (PFS) of BC patients. Utilizing the immunohistochemical assay, we found that PCMT1 protein was located in the cytoplasm of BC cells, and PCMT1 expression was only obviously correlated with progesterone receptor expression of patients (p < 0.05). Survival analysis showed that PCMT1 protein high-expression was an independent unfavorable prognostic factor for BC patients. The in vitro experiments revealed that PCMT1 could regulate growth, migration and invasion capacity of MCF-7 cell, and modulate the expression of AKT/GSK3β/mTOR signaling pathway, EMT and cell cycle-associated protein. In conclusion, PCMT1 was a potential unfavorable prognostic biomarker for BC patient and might influence the AKT/GSK3β/mTOR signaling pathway to regulate the growth and motility of MCF-7 cell.
Dual orexin receptor antagonists and Tgn-020 affect learning and memory in 8-mth-old APP / PS1 (AD) mice
Authors: Zhou mengzhen , Li Yaran , Tang Shi
Published: December 2022

Objective: To explore which dose of Dual orexin receptor antagonist (DORA, using Almorexant) can improve mouse sleep without damaging mouse learning and memory, and whether there are serious adverse effects. Explore whether AQP4 blockers (TGN-020, abbreviated TGN) can affect Aβ deposition.
Methods: divided into two rounds of experiment, 71 mice were randomly divided into 6 groups in addition to the control group 8,11 mice, the first round of DORA injection 10mg / kg group, 30mg / kg and 60mg / kg group mice, intraperitoneal injection for 28 days, while monitoring sleep, 28 days of Y maze and water maze experiment, behavioral experiments after death of mice, immunohistochemistry. A second round of experiments was followed by the TGN + 30 group of TGN (AQP4 blocker) and 10mg / kg blocker) and TGN+ 30mg / kg of DORA.
Results: The total sleep time of each group was statistically significant compared with the control group (10mg / kg: 12:6 minutes; 30mg / kg: 14:27 minutes; 60mg / kg: 16:57 minutes, P <0.001). With control mice (hippocampal area 0. 181 ± 0.05, Cortical Area 0.185 ± 0.07) compared to, 10mg / kg (hippocampus 0.177 ± 0.07, Cortical Area 0.155 ± 0.05), 30mg / kg (hippocampus 0.145 ± 0.05), 0.137 ± 0.05) in the Cortical area. The group of mice showed reduced A β 42 plaques in the hippocampus and cortex, The difference in plaque deposition area was statistically significant; In contrast to the con group of mice, The 60mg / kg group (hippocampus 0.106 ± 0.06, Cortical area 0.113 ± 0.06) The mice have the smallest area of the Aβ42 plaques corresponding to the brain areas, The difference was statistically significant. The percentage of free alternation experiments was decreased in TGN group mice and increased in TGN + 30 group mice as compared with the control mice. The percentage of experiments with free alternation in the TGN and TGN + 30 groups was 0.31 ± 0.10 and 0.35 ± 0.16, respectively.
Conclusion: DORA intervention mice have good sleep response and little residual effect, DORA intervention can improve the working memory of APP / PS1 mice; DORA can reduce Aβ deposition, slow down the neurodegeneration of Alzheimer's disease, TGN will increase Aβ deposition; 30mg / kg may be the best dose of Almorexant, can prolong sleep duration without damaging learning and memory; TGN can aggravate neurodegeneration, and damage the learning and memory of APP / PS1 mice.
Polyamide 6.6/Bismuth (III) Oxide Electrospun Nanocomposites for Potential Applications in Electronics
Authors: AYGÜN Hayriye Hale , ALMA Mehmet Hakkı
Published: December 2022

In this study, it is aimed to observe electrospinnability of bismuth oxide (Bi2O3) microparticles via polymer solution and effect of loading on electrical insulating property of electrospun composite structure. For that purpose, polyamide 6.6 polymer (PA6.6) with high dielectric constant was loaded with bismuth oxide microparticles and it was used for coating polyester spunbonds by electrospinning technique. Morphological properties, thermal behaviors and electrical resistance of coated spunbonds were investigated. Scanning electron microscopy (SEM) and electron dispersive X-ray spectroscopy (EDX) showed that Bi2O3 was succesfully adapted into fiber structure and nano-scale PA6.6/Bi2O3 composite fibers were obtained. Thermal behaviors of coated samples were developed by increasing Bi2O3 loading according to differential scanning calorimetry (DSC) and thermogravimetic analysis (TGA) results. Addition of Bi2O3 caused remarkable increase on electrical resistance of PA6.6 electrospun surfaces. Bi2O3 /PA6.6 nanocomposite fibers are promising and good candidates for thin electrically insulating polymer-based structures for micro- or nanodimensional devices.
Association of nitrogen use efficiency in diverse rice genotypes with sustenance of reproductive stage photoassmilation and nitrogen metabolism
Authors: B Jagadhesan , Meena Hari Singh , Jha Shailendra K , KG Krishna , Kumar Santosh , A Elangovan , Chinnusamy Viswanathan , Kumar Arvind , Sathee Lekshmy
Published: December 2022

To maintain yield stability and environmental sustainability of rice cultivation, improvement in nitrogen use efficiency (NUE) is essential. We identified rice genotypes showing high NUE in control (N120) and N deficient (N0) field conditions by analyzing NUE parameters and different contributing traits. In the first season, genotypes BAM-3181, BAM-4797, BAM-3154, NL-26 IR-83929-B-B-291-3-1-1 (IR-3-1-1), APO and NERICA-L-42 showed high biomass, panicle yield and N utilization efficiency (NutE) at low N field conditions. Reproductive stage N assimilatory and signaling gene expression was correlated to the variation in NUtE. The sequence variation in N metabolism and signaling (NLP) genes were analyzed in selected genotypes (APO and NERICA-L-42). Significant non-synonymous SNPs were found in NPF2.2, PTR2, NGR9 (DEP1), Fd-GOGAT, NLP3, NLP4 and NLP5 genes of APO, NERICA-L-42 and w.r.to japonica genotype Nipponbare. The significant variation in reproductive stage gene expression and changes in amino acid sequence of NLP3, NLP4, NLP5 among rice genotypes differing in NUE is an unexplored and potent genome editing target for high NUE in rice. The non-synonymous SNPs identified in the study will be important genomic resources for improving rice NUE.
Love Canal: Health Effects and Clean Up Costs
Authors: Zelalem Mengistu
Published: December 2022

The Love Canal is a hazardous waste dump-site located in the center of a middle class community in Niagara Falls, New York" which was used as municipal and chemical waste disposal area for residue from the manufacture of chlorinated hydrocarbons from the 1920s until 1953 when it was covered with earth. Perhaps because they didn’t understand the potential risks associated with Hooker’s chemical wastes primary schools and homes had been constructed around the canal .The tragedy of Love Canal were damaged countless families and ruined the environment for many years. The toxic contamination found throughout the soil brought emotional as well as physical pain to those who had purchased homes in the Love Canal area or who had sent their children to its school system. The various additional substances discovered at Love Canal produce a range of acute, sudden symptoms as well as chronic or long term health problems. Proper disposal of hazardous waste is important in protecting the public health. Site selection and site preparation are important factors to be considered for hazardous waste disposal. Overall, the chemical cleanup process is time consuming and costly and this is why it is so important to dispose of toxic waste in proper facilities where the substances will not come into contact with people and pollute their land and water supplies.
Example elements of programming based on construction of interactive appliction for lathe operators training.
Authors: Filipek Dariusz
Published: December 2022

The paper presents examplary solutions of programming based symulator project of conventional lathe. This symulator was elaborated in Central Institute for Labour Protection – National Research Institute. Symulator as a part of test stand for interactive handling of Lathe is suporting and suplemenary training tool . This tool serves to improving of safe handling machines of this type.
PENYULUHAN VAKSINASI COVID-19, PERSIAPAN PRE VAKSIN DAN TINDAKAN PASCA VAKSIN
Authors: Probowati Wiwiek , Jayadi Tejo , Rustam Brenda Miriane , Putri Agatha Maheswari Adita
Published: December 2022

Abstrak

 

Intisari : Pada April 2021        kasus covid di Indonesia sebanyak 1.69 juta, dengan jumlah kesembuhan adalah 1.35 juta dan meninggal sebanyak 40.858 kasus. Angka ini tidak dapat dianggap sebagai angka yang kecil, Indonesia masuk dalam urutan ke-18 negara dengan kasus covid-19 tertinggi dan nomor 1 tertinggi di Asia tenggara. Pada tanggal 13 Januari 2021, Indonesia resmi memulai pemberian vaksin kepada masyarakat, namun pemberian vaksin gratis oleh pemerintah ini masih mendapatkan pertanyaan dan penolakan dari masyarakat.

Tujuan : Meningkatkan pemahaman masyarakat terhadap pentingnya vaksinasi Covid-19, mengenal beberapa keadaan yang menjadi kontraindikasi pemberian vaksinasi Covid-19 dan penatlaksanaan apabila terjadi Kejadian Ikutan Pasca Imunisasi (KIPI)

Metode : Penyuluhan dan Diskusi derta mengevaluasi pemahaman masyarakat dengan pre test dan post test yang dilakukan oleh masyarakat desa Miliran.

Hasil evaluasi :  edukasi dan diskusi terkait vaksinasi Covid-19 di desa Miliran mampu mengubah paradigma masyarakat terhadap vaksinasi Covid-19 untuk bisa menerima vaksinasi covid-19 dengan baik. Penyuluhan  di desa Miliran ini mendapatkan respon positif masyarakat dengan peningkatan nilai postes dan bangkitnya keinginan masyarakat dalam menyebarluaskan kesadaran melkukan vaksinasi Covid-19.

 

Kata kunci : Covid-19, Penyuluhan, Vaksin
BUTIK SAMPAH MINI-WORKSHOP UNTUK MENGURANGI LIMBAH PAKAIAN MENJADI KERAJINAN TAS
Authors: Arsanti Vidyana , Sekarsih Fitria Nuraini
Published: December 2022

Meningkatnya kesejahteraan akan diikuti dengan pola hidup yang semakin konsumtif. Hal ini berkontribusi terhadap jumlah sampah yang dihasilkan terutama limbah pakaian. Kondisi ini, menggerakkan tim Amikom bersama Faskel Bener, Bapak Lurah, pengurus BERAMAL (Bener Ramah Lingkungan), Ketua Rukun Warga dan Ketua Pokja IV PKK membuat inovasi pengelolaan sampah. Kegiatan ini berlokasi di Kalurahan Bener dengan mengerahkan partisipasi masyarakat. Tujuan kegiatan ini adalah mengatasi permasalahan limbah pakaian sekaligus meningkatkan kualitas lingkungan. Hasil dari kegiatan masyarakat ini adalah kegiatan pelatihan mengubah limbah pakaian menjadi kerajinan tas. Luaran dari kegiatan masyarakat ini berupa peningkatan skill ketrampilan para pengurus bank sampah untuk mengatasi limbah pakaian dan menambah pendapatan dari hasil penjualan tas. Selain itu kerajinan Daur Ulang Sampah juga sudah dibuat video tutorial pembuatannya. Kesimpulan dari kegiatan ini: (1) Limbah pakaian dapat digunakan untuk membuat produk turunan lain (recycle) salah satunya adalah tas rajut. (2) Dibutuhkan waktu sekitar 2 jam untuk peserta belajar merajut produk pakaian ini. (3) Nilai produk limbah pakaian tersebut dapat bernilai jual sehingga dapat meningkatkan ekonomi masyarakat.

 

Kata kunci: butik sampah, kerajinan tas, limbah pakaian, mini workshop, recycle
Peningkatan Pola Berpikir Komputasi pada Siswa/i SMAK MATER DEI Melalui Bahasa Pemrograman Java dan Python
Authors: Wiryasaputra Rita , Salomo Albert , Sevani Nina , Seruni
Published: December 2022

Pada era industri 4.0, perkembangan ilmu pengetahuan khususnya pada bidang teknologi dan informasi berkembang sangat cepat. Hal ini menuntut setiap jenjang pendidikan di Indonesia agar mempersiapkan peserta didik beranjak ke dalam dunia teknologi. Maka dari itu, peserta didik harus dibekali dengan pemahaman terhadap Computational Thinking (CT). CT merupakan metode untuk melatih cara berpikir dalam memecahkan masalah menggunakan beberapa teknik dalam bidang ilmu komputer sains dan informatika. Dengan adanya penerapan CT, peserta didik dilatih untuk berpikir secara bertahap, sistematis, dan kreatif menggunakan komputer dan internet. Melalui penerapan pengajaran ini, diharapkan dapat memajukan pemikiran setiap peserta didik di Indonesia agar mereka bisa bersaing di dunia kerja nantinya. Oleh karena itu, Program Studi Informatika, Fakultas Teknik dan Ilmu Komputer, Universitas Kristen Krida Wacana, bekerjasama dengan SMAK Mater Dei dengan mengadakan pelatihan pemrograman berupa kegiatan ekstrakurikuler. Kegiatan pelatihan ini berlangsung dari 10 Agustus 2021 sampai 9 November 2021. Pelatihan diadakan selama 10 pertemuan dan dibagi menjadi 3 fase, persiapan, pelaksanaan dan evaluasi. Materi pemrograman meliputi penggunaan IDE Greenfoot dan bahasa pemrograman Python menggunakan beberapa metode pengajaran. Pengukuran kemampuan siswa/i akan diuji menggunakan model pengujian pre-test dan post-test. Pelatihan ini berlangsung dengan baik dan pemahaman siswa/i terhadap pola pikir komputasional meningkat setelah diadakannya program ini.
Determination of Coumarin in Mikania glomerata Infusions by Square-Wave Voltammetry Using a Boron-Doped Diamond Electrode
Authors: Nóbrega Denise , Lourenço Anabel , Fernandes David Douglas , Lyra Wellington , Moreira Edilene , Diniz Paulo Henrique , Araújo Mario
Published: December 2022

Infusions of Mikania glomerata Sprengel (guaco) leaves are used in Brazil for the treatment of respiratory diseases. Coumarin is the chemical marker of guaco for quality control purposes. This work proposes a voltammetric methodology to determine coumarin by using a borondoped diamond electrode. At pH 10 (0.1 mol L-1 Britton-Robinson buffer solution), coumarin is irreversibly oxidized around +1.77 V in a process predominantly controlled by diffusion. The methodology described here presented a linear range from 1.54 to 15.3 μg mL-1 with limits of detection and quantification of 0.20 and 0.62 μg mL-1, respectively. Analysis of variance confirmed the significance of the regression and the absence of lack-of-fit at the confidence level of 95%. Infusion of commercial guaco leaves was directly analyzed, and results were in agreement with high-performance liquid chromatography after applying the paired t-test at a confidence level of 95%.
COMPARISON OF MOTOR PERFORMANCE BETWEEN CHILDREN WITH MULTIPLE DISABILITIES AND TYPICAL DEVELOPMENT
Authors: GÜVEN Zeynep , YILDIZ KABAK Vesile , DEMİRCİOĞLU KARAGÖZ Arzu , ÇEVİK Nurcan , ATASAVUN UYSAL Songul
Published: December 2022

Purpose: Individuals with multiple disabilities have two or more disabilities at the same time, and these impairments can cause qualitatively and quantitatively insufficient motor performance. This study aimed to compare the motor performance of children with multiple disabilities to children with typical development.

Methods: This prospective study included 26 children with multiple disabilities who had visual impairment according to the International Statistical Classification of Diseases and Related Health Problems: 11th Revision, and 20 children with typical development. The Bruininks-Oseretsky Test of Motor Proficiency Second Edition Short Form was used to examine motor proficiency. A standard hand dynamometer and pinchmeter were used to assess hand and finger grip strength. The Nine-Hole Peg Test was used to evaluate performance-based hand functions.

Results: Children with multiple disabilities had lower scores for balance control (p
THE RELATIONSHIP BETWEEN TRUNK MUSCLE STRENGTH AND PELVIC OSCILLATION IN ASYMPTOMATIC PHYSICALLY INACTIVE ADULTS
Authors: ZORLULAR Ali , AYGUN POLAT Elif , KAFA Nihan , ATALAY GÜZEL Nevin
Published: December 2022

Purpose: Pelvis and trunk structure are body segments that are integrated with each other. Collaboration between pelvic mobility and trunk muscles plays a significant role in walking and energy consumption. The aim of this study is to investigate the relationship between trunk muscle strength and pelvic oscillations.

Methods: Twenty-eight healthy individuals volunteered for the study (16 women, 12 men; mean age 24.46 ± 2.97 yrs., height 172.03 ± 9.41cm, weight 67.78 ± 16.31 kg). Pelvic oscillations were measured by using a wireless tri-axial accelerometer. Trunk muscle strength was evaluated with Isokinetic Dynamometer (Cybex Humac Norm Testing & Rehabilitation System, USA). The trunk extensors and flexors were tested concentrically at 60°s. Statistically, the direction and level of the relationship were examined by using Spearman Correlation Analysis.

Results: Correlation analysis showed significant relationships between concentric strength of trunk flexion and anterior-posterior pelvic tilt (r=-0.419 p
Topical application of gentamicin or cephalothin in the healing of surgical wounds in dogs
Authors: Minto Bruno Watanabe , Pazzini Josiane Morais , Kawamoto Fernando Yoiti Kitamura , Franco Guilherme Galhardo , Borsaro Camila Portério , Zanato Laura , Hama Lismara Castro do Nascimento , Amoroso Lizandra , Magalhães Thaís Vendramini
Published: December 2022

The present study aimed to evaluate the influence of local administration of gentamicin or cephalothin on the healing of surgical wounds in dogs. Thirty healthy dogs were submitted to surgical castration. They were divided into 2 groups of 15 animals. After the surgical procedure, two 0.6 cm circular cutaneous wounds were made in the abdominal region. Group 1 received 0.1 ml of 0.9% saline in one wound and 0.1 ml of gentamicin (40 mg / ml) in the other wound; and group 2 received 0.1 ml of 0.9% saline and 0.1 ml of cephalothin (200 mg / ml); respectively. All wounds were sutured and assessed macroscopically 1, 3 and 10 days after the operation. On day 10, an incisional biopsy was performed for histopathological evaluation. All analyzes of macroscopic variables did not show significant differences between groups (P <0.05). There were no significant differences between groups for microscopic evaluation of collagenization, vascularization, edema and inflammatory cells (P <0.05). Thus, the topical use of the tested antibiotics does not influence skin healing in dogs.
CD4+ and CD8+ T lymphocyte counts and ratio in cats with chronic gingivostomatitis and naturally infected with feline immunodeficiency virus: a preliminary study
Authors: Haipek Kátia , Daniel Alexandre Gonçalves Teixeira , Filgueira Kilder Dantas , Sellera Fábio Parra , Gargano Ronaldo Gomes , Kfoury Júnior José Roberto , Oliveira Lilian de Jesus , Cunha Janaína Munuera , Reche-Júnior Archivaldo
Published: December 2022

This study aimed to evaluate the CD4+ and CD8+ T lymphocytes counts and CD4+: CD8+ ratio in a colony of cats with chronic gingivostomatitis (CGS). We used forty domestic short-haired cats inhabiting the same colony. Ten cats with CGS were immunodeficiency virus-positive (group IV), and ten with CGS were immunodeficiency virus-negative (group III). As a control, twenty cats without CGS were used: ten cats were immunodeficiency virus-positive (group II) and ten cats were immunodeficiency virus-negative (group I). We employed flow cytometry to count CD4+ and CD8+ T lymphocytes. In cats infected with the immunodeficiency virus, the presence of CD4+ lymphocytes were lower both for animals with and without CGS. Conversely, not immunodeficiency virus-infected cats with CGS had a higher amount of CD4+ when compared to seronegative animals without CGS. The counts of CD8+ T lymphocytes showed no significant difference among cats with CGS, whether infected with immunodeficiency virus or not. The CD4+: CD8+ ratio was only different for group III, which was higher than any other group. No difference was observed for total lymphocyte number and CD8+ among groups. By contrast, mean CD4+ levels were different, with cats from groups III and IV showing higher levels than those from groups I and II. The flow cytometry could be a useful tool for the diagnosis and prognosis of cats with CGS infected by the immunodeficiency virus.
Urinary Incontinence and Quality of Life in Women With Cystic Fibrosis
Authors: Soares Marinice Nunes , Paiva Luciana Laureano , Dalcin Paulo de Tarso Roth , Ziegler Bruna
Published: December 2022

Introduction:

Stress urinary incontinence (SUI) is recognized as a common complication in women with CF.

Objective:

The primary objective of this study was to verify the prevalence of urinary incontinence (UI) and its associations with quality of life (QoL) in adult women with CF. The secondary objective was to identify possible associations of UI with cough score, nutritional parameters, and pulmonary function.

Methods:

This cross-sectional study included female patients aged 18 years and older. All patients answered the International Consultation on Incontinence Questionnaire Short Form, the Kings Health Questionnaire, and the Leicester Cough Questionnaire. Nutritional assessment was obtained. Sputum bacteriology and lung function were also performed.

Results:

Fifty-two women were included, with mean age of 29.0±9.7 years and mean forced expiratory volume in one second (FEV1) of 50.1±21.7% of predicted. Thirty-two patients (61.5%) presented symptoms of UI, 23 (44.2%) of stress UI and 9 (17.3%) of mixed UI. However, there was no significant association between UI and pulmonary function, sputum bacteriology, and cough score (p>0.05). There was a significant association between UI and QoL variables (p<0.05).

Conclusion:

This study identified a prevalence of 61.5% of UI in women with CF. The presence of UI in women with CF resulted in a negative impact on QoL.
Acute Pericarditis as the Primary Presentation of COVID-19 Infection followed by Guillain-Barre Syndrome in a Healthy Young Man: A Case Report
Authors: Noghabaei Giti , Arab Maliheh , Payami Sara , Ghavami Behnaz
Published: December 2022

Background:

Symptomatic COVID-19 infection most often presents as acute respiratory distress syndrome. Acute pericarditis and Guillain–Barré syndrome are rare extrapulmonary manifestations of this infection.

Case Presentation:

A 27-year-old man presented with chest pain, with negative troponin and typical electrocardiographic findings, resulting in a diagnosis of acute pericarditis. He had no respiratory symptoms, nor the chest computerized tomography (CT) scan findings of COVID-19, and his Polymerase chain reaction (PCR) was negative. One week later, he developed clinical symptoms of Guillain-Barre syndrome, along with respiratory manifestations of COVID-19. His repeat chest CT scan and PCR test confirmed COVID-19 infection. After 17 days of hospital stay, he improved clinically and was discharged.

Conclusion:

This is the first case of acute pericarditis as the primary presentation of COVID-19 in the absence of respiratory symptoms and a clear chest CT scan, followed by the development of Guillain–Barré syndrome and respiratory tract manifestations of COVID-19. Clinicians should be aware of the extrapulmonary presentation of COVID-19 infection.
In-silico Identification of Novel Drug Target for Osteoarthritis using Network Biology Approaches
Authors: Shukla Nityendra , Srivastava Neha , Trivedi Aditya , Seth Prahlad Kishore , Srivastava Prachi
Published: December 2022

Osteoarthritis (OA) is a degenerative joint disease which is the leading cause for physical disability among the adult population and yet the mechanisms responsible for the development and progression are not well understood. Since it has no curative solutions, treatment is limited to symptomatic targeting and improving quality of life. There is a lack of disease-modifying therapeutics and non-surgical intervention options to prevent the progression of disease. Risk factors range from systemic (e.g. age, sex, genetics, obesity) to biochemical (e.g. joint injury, muscle weakness, sport). The prevalence of OA is ever increasing due to the ageing global population and the obesity epidemic. Since OA exhibits strong genetic predisposition and a complex pathogenesis, we applied an in silico network biology approaches to identify a candidate gene using a protein-protein interaction (PPI) network of OA, which may be an important aspect of disease pathogenesis and assist us in furthering our understanding of the development and progression of the disease as well as identify a drug-lead for the treatment of joint-pain associated with OA and improving quality of life in patients without lasting side effects. Our findings suggest that phytochemical

compounds may be promising candidates for multi-target application against OA and will assist in development of new molecules.
Population Exposure to Particulate Matter and COVID-19: An Ecological Study for Health Promotion
Authors: Sarmadi Mohammad , Rahimi Sajjad , Arefi Maryam Feiz , Aghabeigi Arash , Yektay Sama , Sanaei Daryoush
Published: December 2022

Background:

Documentation of the association between ambient pollution and severe coronavirus disease 2019 (COVID-19) infections are complicated and vague.

Objective:

This short research investigated the distribution of COVID-19 and its association with particulate matter before mass vaccination.

Methods:

We used the reported cases and deaths per capita and PM2.5 (particulate matter ≤ 2.5 μm) in 245 cities in the United Kingdom (UK) and United State, of America (USA) based on publicity available secondary data. We performed correlation and regression analysis between variables to explore the association between COVID-19 and PM2.5.

Results:

The analysis revealed that PM2.5 positively correlated with cases (Unstandardized Coefficient (b):150.04, P=0.006) and deaths per capita (b: 3.87, P=0.005) in total cities, after adjusting for median age and population density.

Conclusion:

The findings showed that the distribution of the disease may be affected by the PM2.5 concentration.
COVID'19 - Future of India with Safety and Security Measures
Authors: Rekha Gillala
Published: December 2022

A lot of awareness has been created by the government of India on the spread of the COVID-19 pandemic. Many precautions have been initiated by the Central government and followed by the state government. The entire country of India was unaware of what the consequences would be until it reached the country. Though thedisease broke into the world society during December 2019, there was not much impact on a huge country like India though it had its borders widespread with China. The economy was on the rise, and the country was about to become stable, and many growth activities were planned by both the central and state governments. Normal life was at ease before the outbreak of the pandemic. People across the country had been doing their daily activities without any hindrances. Hence, the paper presents the major economic conditions pre and post lockdown. It also covered people who were worst hit by the pandemic. However, light can be seen after a dark patch in the form of safety and security measures which are discussed in detail. Safety and security measures are the major things thata normal human being can do in such pandemics.
COVID-19 and Central Nervous System Manifestations: A Systemic review on Therapeutic Outcome
Authors: Raj Khadga , Gupta G.D. , Singh Shamsher , Chaudhary Ankit
Published: December 2022

A novel caused the outbreak of coronavirus disease (COVID-19) has spread to Wuhan city of China and has become a global health issue and severe concern of the international community. Elderly patients with comorbidities, such as hypertension, diabetes mellitus, heart and lung disease, are more prone to COVID-19 Infection. COVID-19 and neurological disorders are two conditions with a well-documented association recently. Studies have shown that Infection with COVID-19 can alter the clinical spectrum of manifested neurological disorders and plays a vital role as long-term consequences in the development of diseases in the future. The SARS-CoV-2 virus reaches the brain either by an olfactory or by a hematogenous route pathway. Angiotensin-converting enzyme-2 (ACE-2) receptors, present in cerebral vessel endothelial cells of a cerebral vessel, are a potential viral entry point. Several cases of neurological disease have been identified recently, including Alzheimer's disease, Multiple sclerosis, and Parkinson's disease in COVID-19 patients, and a post-infectious immune-mediated inflammatory pathway has been held responsible for this. In this study, we try to explore the effect of COVID-19 on central nervous system damage and treatment of these manifestations. COVID-19 pandemic spreads to different parts of the world, the spectrum of neurological complications can expand further.
Introduction to Nanoparticles and Nanocarriers
Authors: Kumar Jain Amit , Gahlot Neha
Published: December 2022

This chapter outlines the introduction of nanoparticles and nanocarriers,
within which it delineates their classification into various categories of polymeric
nanoparticles, metal nanoparticles, magnetic nanoparticles, inorganic nanocarriers,
dendrimers, vesicular carriers, micelles, and a lot more, their synthesis techniques such
as physical, chemical and biological, and their application in the medical sector. The
chapter also focuses on various challenges faced by these nanocarrier systems in
nanomedicine as well as their advantages over conventional drug delivery. Overall, this
chapter is a comprehensive compilation of available information on recent advances in
the field of nanomedicine through an elucidation of nanoparticles and nanocarrier
systems. During the last decade, surplus new nano-based strategies for improved drug
delivery and nanocarriers centered therapeutic approaches have been adopted for oral
drug delivery, pulmonary drug delivery, cutaneous drug delivery, drug delivery into the
brain, for cardiovascular diseases, intracellular targeting, gene delivery, protein
delivery, insulin delivery, anticancer targeting and many more. Currently, nanoparticle.integrated diagnosis and imaging have been in abundant use seeing an urgent need for
early detection and diagnosis of various lethal diseases.
Nanomaterials as Diagnostic Tools and Drug Carriers
Authors: Parashar Ashish K. , Patel Preeti , Kaurav Monika , Yadav Krishna , Singh Dilpreet , Gupta G.D. , Kurmi Balak Das
Published: December 2022

Nanotechnology is a multidisciplinary field of study that bridges chemistry,
engineering, biology, and medicine. The utilization of the nanotechnological approach
for the development of theranostic nanocarrier system is capable of being loaded as
drug therapy/delivery and diagnostic vehicles/means. A very recent term, theranostic
nanomedicine, has gained much attention as a favorable model for various types of
progressive disease. Theranostic nanocarriers' strategy utilizes the diagnostic
excellence mediated treatment of such illnesses that required individual therapy, such
as in cancer. These can impart an essential role in improving public health regarding
high-stress lifestyle-related challenges in diabetes, asthma, cancer, hypertension, and
many infectious diseases, as the diagnosis of these circumstances and the treatment
strategy, are also possible with biomedical applications of these nanomaterials. It
includes benefits from both worlds: highly powerful nanocarriers to drug delivery and
diagnosis spawned the concept, enabling the emergence of personalized medicine. This
chapter discusses the state of various nanocarriers' art in the form of NPs and
nanodevices applications in medical diagnosis and disease treatments. It presents key
insights and current advancements into the intriguing biomedical applications of NPs,
including bioimaging of biological surroundings and their significance as a critical
early detection tool for various diseases. It also describes their types and limitations
concerning conventional means. The topic has attracted significant attention and
interest as diagnostic and treating nanocarriers' can target various illnesses faced by the
healthcare providers suggested by several researchers over the past decade.
Additionally, with recent advances in nanoscience and nanoscale materials, the creation
of different diagnostic or therapeutic devices is also discussed briefly. Along with
nanocarrier systems' therapeutic and diagnostic aims, physicochemical advantages even
considerable potential to be studied concerning health system, which is useful for protecting active drug molecules from degradation, targeted and site-specific drug deliveries are also discussed. Despite the numerous technological, scientific, regulatory,
and legal hurdles that nanomedicine faces, researchers are driven to develop new
medications and nanomedicine devices. As a result, the development of nanoparticle-based drug delivery and diagnostic devices could help improve patient comfort and
convenience while also lowering treatment costs.
Nanoemulsion: A Potential Carrier for Topical Drug Delivery
Authors: Kesavan Karthikeyan , Mohan Parasuraman , Jain Sunil K , Parra-Marín Olivia , Murugesan Selvasankar
Published: December 2022

Nanoemulsions (NEs) are stable nanocarrier systems consisting mainly of
oil and water, which are stabilized by surfactant with cosurfactant. Due to their typical
size, nano-emulsions are transparent or translucent, and minute droplet size makes
them stable against sedimentation or creaming. The nanoemulsion system may be in
the form of oil-in-water (O/W) or water-in-oil (W/O). The recent literature revealed
that NEs as a colloidal carrier system has been confirmed to be a valuable strategy to
improve the bioavailability of topically applied drugs. NE has been proposed as a
viable alternative to conventional topical dosage forms due to the ability to overcome
the skin/ocular barriers faced after administration. Better permeation rate, improved
therapeutic efficacy and reduction of dose, non–specific toxicity, and targeted drug
delivery system can improve drug effectiveness when drugs are incorporated into NEs.
In recent years, research studies have focused more on ion nanoemulsion systems using
a mixture of surfactants to solve critical factors, such as solubility, stability, and drug
delivery applications. This chapter outlines the recent development in nanoemulsion as
a delivery system to study topical drug delivery.
closing holywings bar between law and government policy in the era of information disclosures and public trust
Authors: Rospita Rospita , Purwadi Ari , Zulqarnain Zulqarnain , Santy Santy , Triantoro Miranu
Published: December 2022

This study aimed to discuss the closure of the Holywings between legal approaches and government policies in an era where information is increasingly flowing, and people trust the Law. The information and data that we collect from various sources, we examine the criminological approach, which involves coding data, sharp analysis, and also in-depth interpretation to get data that we can answer the problem in terms of credit and quality. Considering that the data on this issue is minimal, we are trying to find data -data that we get from various sources that we have used to answer the problem. After the discussion, the closure of the Holywings is based on the principle of legal justice for all business people. Also, the demands of the community where the holy wings bar business needs an active license. They have violated state regulations and policies and made a mistake in promoting sensitive religious figures. with the names of Muhammad and Mary. Having had breakfast, this friend will complete the study of legal science and also regulations regarding business permits that are being carried out.
The exploration of students and teachers’ view on ecological storybooks
Authors: Kurnia Nandy Intan , Anggraeni Niken , Fitri Cindy Elsa
Published: December 2022

Environmental issues are on-going crises that have yet found sufficient solutions. Children, as the next generation, must be given the trust to be able to get in touch with environmental issues as form of children’s empowerment and preservation act. This study aims to describe the views of elementary school students and teachers related to children’s ecology-themed storybooks. This research is qualitative, the data collection uses a list and guided interview questions, observation sheets, questionnaire sheets, and expert validation sheets. The results of the study are as follows. First, there is a lack of ecological books in major bookstore in Yogyakarta, Indonesia. The existing children books containing environmental theme only included it as a supporting theme. This may result in most children participant to be not interested in such books.  Second, teachers are mostly in agreement as to how children ecological storybook should appear ideally. This includes realism as the story’s genre, explicit theme, forest settings, picture book form, human characters nature vs human conflict, and happy closed ending for the story. All of these are believed to be able to educate children on the on-going environmental crisis and to encourage the children to face them.Keywords: children’s storybooks, ecology, children’s empowerment, environment, children’s literature
Conservation Agriculture as a Potential Strategy to Increase Soil Quality in Colombian Agroecosystems
Authors: Ardila-Garcia Valentina , Vallejo Victoria Eugenia , Plazas-Navarro Leidy Paola
Published: December 2022

Conservation Agriculture (CA) has been promoted in many Latin American countries as an alternative to sustainable production management because of its ability to prevent soil degradation, enhance crop productivity, minimize climate change impact, and protect soil biodiversity. The main objective of this paper was to evaluate the effects of CA on Soil Quality (SQ) in five agroecosystems from Cachipay (Cundinamarca): Coffee Crop (CC) chronosequences of (1) 5 (CC5) and (2) 10 (CC10) years of establishment; Polyculture Cropping System (PCS) chronosequences of (3) 1 (PCS1) and (4) 6 (PCS6) years, and (5) Fallow (F) systems. A Minimum Data Set (MDS) was determined from principal component analysis. Aggregate stability index, aggregate stability, water holding capacity, geometric mean diameter, electric conductivity, heterotrophic bacterial density, and catalase were finally selected into the MDS and used in the calculation of the Soil Quality Index (SQI). CC5 (0.71), CC10 (0.67), PCS6 (0.66), and PCS1 (0.65) had a higher SQI in the study area than F (0.60). The study demonstrated the positive effect of CA practices based on minimum soil disturbance, lower inputs of agrochemicals, permanent soil organic cover with crop residues, and a diversified cropping system on SQ. The MDS-SQI approach represents a practical, promising, and adequate tool for monitoring SQ in agroecosystems.
Características químicas y fermentativas in vitro de dietas para becerros con inclusiones crecientes de vaina y hojas de Moringa oleifera
Authors: Sánchez-Santillán Paulino , Rivera-Cristóbal Conchita , Torres-Salado Nicolás , Almaraz-Buendía Isaac , Herrera-Pérez Jerónimo
Published: December 2022

Las hojas y las vainas de las leguminosas son una alternativa de alimentación de rumiantes en el trópico. El objetivo del presente estudio fue determinar las características químicas y fermentativas in vitro de vaina y hoja de Moringa oleifera, con inclusiones de 0 %, 10 %, 20 % y 30 % en una dieta integral para becerros de 200 kg de peso vivo. A las hojas, las vainas y las dietas se les determinó materia seca (ms), proteína cruda (pc), fibra detergente (fdn), producción acumulada de gas y metano, degradación de ms (dmd) y fdn (dfdn). El análisis de las variables fue mediante un diseño completamente al azar (10 repeticiones) y la hoja cuantificó 229,4, 465,8 y 204,0 g/kg ms de ms, fdn y pc, respectivamente. Así como, 662,3 y 688,9 g/kg de ms de dms y dfdn (P < 0,05). La dieta con 10 % de hoja de M. oleifera presentó 824,9 y 725,5 g/kg de ms de dmd y dfdn, así como 167 y 58 ml/g ms de gas y metano. En conclusión, la hoja de M. oleifera muestra mejores características químicas y fermentativas in vitro y se puede incluir hasta 30 % de hoja de M. oleifera en dietas integrales para becerros de 200 kg de peso vivo.
Characterization of α-Glucosidase Inhibitor Streptomyces sp. IPBCC.a.29.1556 Aqueous Extract: An Endophyte of Indonesian Ficus deltoidea
Authors: Janatiningrum Isra , Lestari Yulin , Solihin Dedy Duryadi , Meryandini Anja
Published: December 2022

Filamentous bacteria have been known as actinobacteria which could produce various secondary metabolites, including an α-glucosidase inhibitor. The α-glucosidase inhibitor has been identified to be potentially valuable for the treatment of diabetes mellitus. Endophytic actinobacteria are able to produce bioactive compounds that are similar to their hosts. Indonesian Ficus deltoidea is one of the medicinal plants which has the activity of the α-glucosidase inhibitor. The α-glucosidase inhibitor has been characterized by optimizing compound production, fractionation, analysis using TLC and LC-MS, and identifying inhibitor mechanisms. The α-glucosidase inhibitor substance is present in Streptomyces sp. IPBCC.a.29.1556 aqueous extract. The aqueous extract was separated and fraction 1 had an IC50 value of 58.8 μg/mL, which is better than acarbose (IC50 = 90.4 μg/mL). Kinetic studies revealed that this fraction inhibited the enzyme through a non-competitive mechanism. Chemical profile based on LC-MS, fraction 1 showed the presence of Phenylpropynal, Butyric acid, 2-(2-Ethoxyethoxy)ethanolate, 1,1-Diethoxyethane acetate, N,N-dimethyl-3-oxide-1H-Benzotriazole-1-propanamine, p-coumaric acid, and isoquinolinium which might contribute individually or synergistically to the observed α-glucosidase inhibitor activity. These results suggest that fraction 1 from the aqueous extract of Streptomyces sp. IPBCC.a.29.1556 is the potential source to produce an α-glucosidase inhibitor for the management of postprandial hyperglycemia.