Icosapent Ethyl Reduces Ischemic Events in Patients With a History of Previous Coronary Artery Bypass Grafting: REDUCE-IT CABG
Authors: Verma Subodh , Bhatt Deepak L. , Steg Ph. Gabriel , Miller Michael , Brinton Eliot A. , Jacobson Terry A. , Dhingra Nitish K. , Ketchum Steven B. , Juliano Rebecca A. , Jiao Lixia , Doyle Ralph T. , Granowitz Craig , Gibson C. Michael , Pinto Duane , Giugliano Robert P. , Budoff Matthew J. , Mason R. Preston , Tardif Jean-Claude , Ballantyne Christie M. , Bhatt Deepak L. , Ballantyne Christie M. , Brinton Eliot A. , Jacobson Terry A. , Miller Michael , Steg Ph. Gabriel , Tardif Jean-Claude , Martens Fabrice M.A.C. , Schut Astrid , Olshansky Brian , Chung Mina , Hallstrom Al , Pearce Lesly , Mehta Cyrus , Mukherjee Rajat , Gibson C. Michael , Chakrabarti Anjan K. , Gelfand Eli V. , Giugliano Robert P. , Leary Megan Carroll , Pinto Duane S. , Pride Yuri B. , Ketchum Steven , Bhavanthula Ramakrishna , Chester Gertrude , Copland Christina , Diffin Katelyn , Doyle Ralph , Erz Kurt , Giaquinto Alex , Glanton Paula , Granger Angela , Granowitz Craig , Iroudayassamy Richard H. , Jiao Lixia , Juliano Rebecca , Jin James , Klevak Dimitry , Panchal Hardik , Wang Robert , Wang Shin-Ru , Abate Gerard , Berry Peggy J. , Braeckman Rene , Doogan Declan , Elson Anne , HauptmannBaker Amy , Lamela Isabel , Lubeck Catherine , Manku Mehar , Murphy Sabina , Sanford Monica , Stirtan William , Soni Paresh , Bastien Arnaud , Foster Demetria , Gascon Evangelito , Johnson Judith , Latona Lasbert , Liu Gang , Palleja Sandra , Sanjuan Nelly , Shi Jimmy , Stager William , Venkatakrishnan Mukund , Youssef-Agha Ahmed , Zhu Julie , Aertker Leela , Ankolekar Suresh , Goldberg Lisa , Rajicic Natasa , Shu Jianfen , Zou Heng , Mikhail Magdy , Dawood Gamil , Koshy N. Mathew , Mukherjee Sandip K. , Abadier Rafik , Lawless Andrea L. , McGuinn William P. , Weintraub Howard , Rohr Kathryn , Claxton Edmund , Weiss Robert J. , Klein Terry D. , Nallasivan Mani , Crowley Stephen , King Marilyn , Alfieri Anthony D. , Fitz-Patrick David , Loh Irving , Mayer Nolan J. , Prashad Rakesh , Lederman Samuel , Weinstein Debra , Bays Harold E. , Chu Keith , Maghsoudi Alireza , Thompson Paul D. , Carstens Jeff , Chang Anna , Cohen Kenneth R. , Dean Julius , Ellison Howard S. , Erickson Bernard , Flores Enrique A. , Gottlieb Daniel W. , Grena Paul , Guyton John R. , Jones Peter H. , Joseph John M. , Lepor Norman E. , Lerman Sam , Matheney Robert D. , Pacheco Theodore R. , Russo Michael B. , Rubino John , Pereira Edward S. , Seals Albert A. , Viera Eduardo , Steljes Alan D. , Thompson Jason , Kapadia Shaival , McIvor Michael , Salazar Jorge E. , Santiago Jose O. , Vicari Ralph , Berk Martin R. , Kaye William A. , McKenzie Marcus , Podlecki David , Snyder Brian D. , Nash Stephen , Herrington David M. , Johnson Wallace , Lee Joseph R. , Blonder Ronald , Patel Alpa M. , Castello Ramon , Greco Susan , Kereiakes Dean J. , Nadar Venkatesh K. , Nathan Mark , Potu Ranganatha P. , Sangrigoli Robert , Smalling Richard , Davis Mitchell , Braastad Robert , McCriskin James , Bodiwala Kunal , Hargrove Joe L. , Graves Mark W. , Emlein George , Durant Raegan W. , Clower James W. , Arora Rohit , Singh Narendra , Warsinger Martin Lisa , Haught W Herbert , Litt Marc P. , Klein Michael D. , Hoagland Peter , Goldstein Michael , Mazzella Marco S. , Dunker Daniel H. , Kahn Brian H. , Ince Carlos S. , McGrew Frank A. , Lee Jay , Pan David , Khan Salman A. , Elkayam Uri , Deeb Wasim , Goldberg Anne C. , Brown Christopher S. , Leimbach Wayne N. , Backer Thomas S. , Sutton David R. , Budoff Matthew J. , Gellman Joel , George Anu R. , Hoffman Alan S. , Kates Mark , Anand Kishlay , Bear Robert , Cavanaugh Brendan J. , Reyes Ramon G. , Sotolongo Rodolfo , Sabatino Kenneth , Gallagher Kevin , Sorial Ehab , Geohas Chris , Magness Kathleen E. , Grunstra Bernard P. , Martin Frederik A. , Knapp William S. , Lucas Mel E. , Champlin John J. , Demattia Jason , Peters Patrick H. , Kirstein Judith , Randall William J. , Staniloae Cezar S. , Robinson Jennifer G. , Adler Alexander , Case Christopher , Kaplan Andrew J. , Lakin Gregory F. , Goyle Krishan K. , DiGiovanna Michael J. , Fisher Chester L. , Lillestol Michael , Robinson Michael , Perry Robert G. , Levinson Lawrence S. , Everhart Brian G. , Madder Robert D. , Martin Earl F. , Martin Earl E. , Alam Imtiaz , Elacion Jose Mari L. , Poonawala Robina , Desta Taddese T. , Robinson Jerome A. , Martinez Gilbert J. , Reddy Jakkidi S. , Wayne Jeffrey D. , Mujica Trenche Samuel , Kaplan Westbrook I. , Saavedra Rubin H. , DiGregorio Michael D. , Bertolet Barry D. , Fraser Neil J. , Hart Terence T. , Graf Ronald J. , Jasper David A. , Dunn Michael , Streja Dan A. , Strobl David J. , Jiang Nan , Kalen Vicki , Mascolo Richard , Samson Mercedes B. , Stephens Michael , Bellard Bret M. , Juarez Mario , McCarthy Patrick J. , Checton John B. , Stillabower Michael , Goldenberg Edward , Karim Amin H. , Jaffrani Naseem , Touchon Robert C. , Fruehling Erich R. , Friesen Clayton J. , Chaudhuri Pradipta , Morris Frank H. , Broker Robert E. , Patel Rajesh J. , Hole Susan , Miller Randall P. , Miranda Francisco G. , Dar Sadia , Gentry Shawn N. , Hermany Paul , Treasure Charles B. , Trevino Miguel E. , Acosta Raimundo , Japour Anthony , Durr Samuel J. , Wang Thomas , Ganda Om P. , Krichmar Perry , Arter James L. , Jacoby Douglas , Schwartz Michael A. , Al-Karadsheh Amer , Gencheff Nelson E. , Pasquini John A. , Dunbar Richard , Kohnstamm Sarah , Lozano Hector F. , Welty Francine K. , Pitts Thomas L. , Zehnder Brian , El Hafi Salah , King Mark A. , Ghitis Arnold , Bahu Marwan M. , Ranjbaran Jahromi Hooman , Caputo Ronald P. , Busch Robert S. , Shapiro Michael D. , Zavaro Suhail , Daudjee Munib , Jacobs Shahram , Shah Vipul B. , Rubalcava Frank , Alhaddad Mohsin T. , Lui Henry , Rajan Raj T. , Saba Fadi E. , Gunapooti Mahendra Pai N , Kayembe Tshiswaka B. , Jennings Timothy , Strzinek Robert A. , Shanik Michael H. , Singh Pradeep K. , Kennedy Alastair C. , Rubenstein Howard , Manshadi Ramin , Herrington David M. , Ladner Joanne , Kakish Lily , Kakish Ashley , Little Amy L. , Gerber Jaime , Hinchion Nancy J. , Guarino Janet , Raychok Denise , Budzinski Susan , Kelley-Garvin Kathleen , Beckord April , Schlinder Jessica , Schwartzbard Arthur , Cobos Stanley , Freeman Deborah , Abisalih David , McCann Dervilla , Guy Kylie , Chase Jennifer , Samuelson Stacey , Cassidy Madeline , Tardif Marissa , Smith Jaime , Sprout Brenna , Riedeman Nanette , Goza Julie , Johnson Lori , Kraske Chad , Hastings Sheila , Dutka Chris , Smith Stephanie , McCabe Toni , Maloney Kathleen , Alfieri Paul , Hosemane Vinay , Syravanh Chanhsamone , Pau Cindy , Limcoiloc April , Carreira Tabitha , Kurosawa Taryn S. , Kurosawa Taryn S. , Krumian Razmig , Preston Krista , Nashed Ashraf , Schneidman-Fernandez Daria , Patterson Jack , Tsakonas John , Esaki Jennifer , Sprafka Lynn , Patel Porous , Mitchell Brian , Ross Erin M. , Miller Donna , Prashad Akash , Feyler Kristina M. , Juarbe Natasha , Herrera Sandra , Keiran Sarah M. , Whitehead Becky , Asher Whitney , Hobbs Coury , Elie Abbey , Brooks Jean , Zaleski Amanda L. , Foxen Brenda , Lapke Barb , Wright Philippa , Pavol Bristol , Carangi Gwen , Turner Marla , Ellison Howard S. , Sanders Katharine W. , Delamar Rikita S. , Wilson Virginia L. , Harvel Sarah M. , Cartledge Alison M. , Bailey Kaitlyn R. , Mahon Kathleen , Schuchard Timothy , Humbert Jen , Hanson Mark C. , Cecil Michael P. , Abraham James S. , Benedict Lorie , Slayton Claudia , Burnett Curtis S. , Ono-Lim Rachel W. , Budzinski Sharon , Khan Shubi A. , Goss Sharon , Techmanski Terry , Valliani Farida , Joseph Rimla , Flores Edith , Contreras Laurn , Aguillon Ana , Silvia Carrie-Ann , Martin Maria , Kerut Edmund K. , Levenson Leslie W. , Glade Louis B. , Cospolich Brian J. , Stein Maureen W. , LaGuardia Stephen P. , Sonza Thelma L. , Fife Tracy M. , Forschler Melissa , Watts Jasmyne , Fritsch Judy , Futchko Emese , Utech Sarah , Baker Scott B. , Roura Miguel F. , Sutton David R. , Segel Scott A. , Magee James S. , Jackson Cathy , Goldfaden Rebecca F. , Quas Liudmila , Ortiz Elizabeth C. , Simpson Michael , Foster Robert , Brian Christopher , Trimm James , Bailey Michael , Snoddy Brian , Reeder Van , Wilkinson Rachel , Settle Harold , Massey Cynthia , Maiola Angela , Hall Michele , Hall Shelly , Hall Wanda , Xenakis Mark , Barrett Janet , Campanile Giovanni , Anthou David , Neill Susan F. , Karas Steven , Polanco Enrique , Schechtman Norberto , Tischner Grace , Warren Kay , St Cyr Cynthia , Kuczinski Menna , Alexander Latrina , Ibarra Maricruz , Horowitz Barry S. , Steinsapir Jaime , Mangual-Coughlin Jeanette , Mooney Brittany , Vasquez Precilia , Rodkey Kathleen , Biberstein Alexandria , Ignacio Christine , Robinson Irina , Hibberd Marcia , Hoffman Lisa B. , Murak Daniel J. , Varavenkataraman Raghupathy , Ohlson Elliott Theresa M. , Cunningham Linda A. , Palmerton Heather L. , Poole Sheri , Moore Jeannine , Wallace Helene , Chandler Ted , Riley Robert , Dawood Farah , Azeem Amir , Cammarata Michael , Owen Ashleigh , Aggarwal Shivani , Qureshi Waqas , Almahmoud Mohamed , Oseni Abdullahi , Leigh Adam , Barnes Erin , Pflum Adam , Aladin Amer , Blinson Karen , Wayne Vickie , Doomy Lynda , Wall Michele , Bitterman Valerie , Young Cindi , Grice Rachel , Poliakova Lioubov , Davalos Jorge , Rosenbaum David , Boulware Mark , Mazzola Heather , Strader J. Russell , Linsky Russell , Schwartz David , Graf Elizabeth , Gneiting Alicia , Palmblad Melissa , Donlin Ashley , Ensminger Emily , Garcia Hillary , Robinson Dawn , Tran Carolyn , Jacqmein Jeffrey , Bartilucci Darlene , Koren Michael , Maluchnik Barbara , Parks Melissa , Miller Jennifer , DeFosse Cynthia , Knouse Albert B. , Delancey Amy , Chin Stephanie , Stephens Thomas , Sohal Mag , Ingram Juana , Kumar Swarooparani , Foley Heather , Smith Nina , McKinney Vera , Schwarz Linda , Moore Judith , Anderson Hildreth Vernon , Sdringola-Maranga Stefano , Denktas Ali , Turrentine Elizabeth , Patterson Rhonda , Marshall John , Tolar Terri , Patrick Donna , Schwartzkopf Pamela , Fletcher Anthony M. , Harris Frances R. , Clements Sherry , Brown Tiffany , Smith William , Baehl Stacey J. , Fluty Robin , VanHamersveld Daniel , Breen Dennis , Bender Nancy , Stafford Beverly , Washington Tamika , Pike Margaret N. , Stich Mark A. , Jawad Evyan , Nadeem Amin , Nyland Jill , Hamer Rhonda , Calhoun Kendra , Mall Charlotte , Cadogan Samuel , Raynes Kati , Katz Richard , Marshall Lorraine , Abbas Rashida , Dinerman Jay L. , Hartley John T. , Lamb Beth , Eskridge Lisa , Raymond Donna , Clemmer Kristy , Fine Denise M. , Beardsley Paula , Werner Janet , Mahan Bette , VanTol Courtney , Herman Robert , Raiser-Vignola Christine , McShan Felicia , Neill Stefanie A. , Blick David R. , Liston Michael J. , Nelson Denetta K. , Dorrell Sandra K. , Wyman Patricia , Quraishi Ambereen , Ferro Fernando , Morris Frank , Coombs Vicki J. , Mains Autumn M. , Campbell Austin A. , Phelps Jeanne , Geary Cheryl A. , Sheridan Ellen G. , Downing Jean M. , Swatkowski Arie , Redden Tish , Dragutsky Brian , Thomas Susan , Mitchell Candace , Barker Diana , Turcotte Elanie , Segerson Deborah , Guy Jill , De La Mora Karena , Hong Jennifer , Do Dennis , Norris Rose , Khan Faisal , Montero Hector , Kelly-White Stacy , Cleland Alan , Alcalde-Crawford Rosalyn , Morgan Melissa , Sarabu Brijmohan , Minor Megan , Kamat Shweta , Estes Stephanie M. , Harless Nancee , Disney Alicia , Pagano Jodi L. , Alford Chad M. , Bedwell Noel W. , Hardy Warren D. , DeAndrade Kevin , Elmore Jessica G. , Auerbach Eric , Haney Anthony W. , Brooks Miriam H. , Torres Jose , Roper Lois , Backer Terry , Backer Katie , Roper Lois , Evans John G. , Magee James S. , Silva Ricardo A. , Dajani Lorraine H. , Segel Scott A. , Yousif Veronica , Ross Tammy , Goldfaden Rebecca F. , Roy Sion K. , Oudiz Ronald , Hamal Sajad , Flores Ferdinand , Leahy Amor , Ayer Debra , George Swapna , Stewart Chrisi Carine , Orellana Elvira , Boccalandro Cristina , Rangel Mary , Hennings Suzanne , Vanselow Carl , Victor Teri , Birdwell Darlene , Haas Paul , Sandoval Anthony , Ciavarella Gina , Saglam Caroline , Bird Amy , Beck Keith , Poliquin Brian , Dominguez David , Tenorio Brittany , Perkins Harvonya , San Roman Esther , Bransford Paris , Lowrance Christy , Broussard Marcy , Ellis Mary , Skiles Bobbi , Hamilton Jessica , Hall Kathryn , Olvera Diego , Maloney Kathleen , Hartwell Julee A. , Sorial Nevien , Anand Kishlay , Rickman Mary , Berman Kevin , Mehta Nirav , Laborin Annie , Saglam Caroline , Rothenberger Rodger , Beauvilliers Sarah , Morrell Kathy , Schachter Michael P. , Perkins Cindy L. , Gordon Elizabeth A. , Lauer Jennifer , Bichsel Kim , Oliver Kelly , Mellor Leslie J. , Demattia Candice , Schomburg Jennifer , Moreno Yenniffer , Mansur-Garza Eduardo , Rippstein Lena , Chacon Lorie , Pena Andrea , King Michelle , Richardson Susan , Jessop Annette , Tucker Nicole , Royer Whitney , Templeton Gilbert , Moell Ann , Weller Christine , Botts Melissa J. , Hollon Gretel , Homberg-Pinassi Elsa , Forest Paula , Abhulhak Aref Bin , Chun-Furlong Devona , Harrington Deborah , Harlynn Emily , Schmitt Marjorie , Shelsky Constance , Feldick Patricia , Cherrico Mary , Jagle Courtney , Warnecke Nicholas , Myer Debra , Ruder Deanna J. , Underwood Albina , Rauba Alan , Carr George , Oberhaus Barbara , Vanderfeltz Jessica , Stucky-Heil Mary Jo , Gibson Dale R. , Fuentes Vonnie , Talbot Kimberly L. , Simon William C. , Grimes Katlyn J. , Wheeler Christina R. , Shultz Cassaundra , Metcalf Rhonda A. , Hill Jennifer L. , Oliver Michelle R. , Ahmad Basharat , Azeem Fouzal , Rahim Abdul , Freeman George H. , Bloch Dawn , Freeman Heather , Brown Jamie , Rosbach Sarah , Melander Pamela , Taralson Nick , Liu Alex , Harms Katlyn , Michale Mahfouz , Lopez Jose , Revoredo Maria , Edevane Shari , Shawley Sarah , Jackson Timothy L. , Oliver Michael J. , DeSalle Dina , Matlock Patricia J. , Beraun Ionna M. , Hendrix Heather , Bromley Garrett , Niemerski Ashley , Teran Gabby , Guerrero Sonia , Marvi Murtaza , Palanpurwala Zehra , Torres Andrea , Gloyd Patty , Conger Michelle , Pena Andrea , Laurent Aziz , Nayor Olia , Villanueva Catalina S. , Khambati Munira , Mumford Tabetha J. , Castillo Melanie J. , Desta Taddese , Robinson Jerome , Woods La Shawn , Bahri Anita , Herrera Nancy , Casaclang Cecilia , Unger Jeffrey R. , Martinez Geraldine , Moon Mia K. , Mohaupt Stephen M. , Sandoval Larry , Valenzuela Louisito , Ramirez Victora , Mata Nelly , Avila Veronica , Patino Marisol , Montano-Pereira Cynthia , Barnett Omar , Webster William M. , Christensen Lorraine M. , Bofman Leighna , Livingston Melanie , Adams Stacey , Hobbs Joseph , Adams Stacey , Koskela Leesa , Katz Mia , Mujica-Trenche Samuel , Cala Franklin , Rana Noreen T. , Scarlett Jennifer , Cala Anaya Milagros , Jones Marsha R. , Hollis Kelly D. , Roth Debbie , Eads Kristin , Watts Tina , Perkins Judy , Arnold Alice , Ginsberg Daniel C. , Quinn Denise , Cureton Nicole , Fittingoff David B. , Iqbal Mohammed I. , White Stephen R. , Sisneros Edith , Ducca Michelle , Streja David , Campos Danny , Boak Jennifer L. , Amir Farzeen , Anderson Felice , Kmetzo James J. , Bongarzone Mary O. , Scott Dawn , De Leon Mary Grace , Buda Cynthia , Graettinger William , Alex Michelle , Graettinger William , Hess Erika , Govoni James , Bartel Melissa , Monchamp Travis L. , Roach Julie S. , Gibson Sara , Allfrey Amy M. , Timpy Kristen , Bott Kathy , Soucy Karin A. , Willis Jean , Valerio Cecilia A. , Chunduri Anusha , Coker Rebecca , Vidrine Nicole , Thompson Ellen A. , Studeny Mark A. , Marcum Melissa K. , Monway Tammy S. , Kosmicki Douglas L. , Kelley Melissa J. , Godfrey Corey M. , Krenk Susan L. , Holcomb Randy R. , Baehr Deb K. , Trauernicht Mary K. , Rowland Lowry David , Bondy Herts Betty , Phelps Jeanne E , Downing Jean-Marie , Gamer Dignon Carol , Cockrill Elisabeth S. , Chapla Pravinchandra G. , Fera Diane , Chang Margaret , Fredette Patricia , Ashby Tamie , Bergin Renee , Stearns Zebediah A. , Ware David B. , Boudreaux Rachael M. , Miranda Francisco G. , Rodriguez Joanna , McKenzie Robert , Huber Amanda , Sommers Rebecca , Rowe Heather , McLallen Stacy , Haynes Michale , Adamson Ashley , Henderson Janice , McClure Lori , Harris Beverly A. , Ference Laura , Meissner-Dengler Sue , Treasure Lisa , Nicely Doreen , Light Timothy L. , Osborn Tracey A. , Mai Kimberly J. , Vivas Pablo , Rios Jose , Rodriguez Dunia , DeRaad Roger , Walder James , Bailon Oscar , Hockett Denice , Anderson Debbie , McIntosh Kelli , Odegard Amber , Shepherd Andrew , Seifert Mary , Kelley Laurence , Shetty Rajendra , Castine Michael , Brill David , Fisher Gregory , Richmond Nicole , Gray Kathleen , Miller Patricia , Coneys Charlene , Chanza Yarixa , Sumoza Monica , Caudill Victoria M. , Harris Kelly D. , Manion Courtney A. , Lineberger-Moore Melody J. , Wolfe Julie J. , Rosen Barbara J. , DiVito Patricia , Moffat Janet L. , Michaelis Christina , Koshy Prashant , Perea Diana , Al Yacoub Ghaith , Sadeghi Stephanie , LeGalley Thomas D. , Evonich Rudolph F. , Jean William J. , Friesen Gary M. , Pap John M. , Pesola David A. , Cowan Mark D. , Dosh Kristofer M. , Larson Dianna , Price Adele M. , Nease Jodi A. , Anderson Jane E. , Piggott Lori A. , Iwaoka Robert , Sharkey Kevin , McMillan Edward , Lowder Laurie , Morgan Latisha , Davis Kyle , Caldwell Tara , Breglio Erica , Summers Jasmine , Poulimas Rachel , Zahid Muhammad , Syed Hamid , Escobar Maria , Levy Jacob , Warsi Rahma , Ma Carol , Cen Puxiao , Cawthon Kimberly A. , Barnes Delores B. , Allen Deanna G. , Warrington Margaret L. , Stastny Carol R. , Michaels Robin J. , Saleh Mohamad , Sorin John , Rathod Sunny , Juett Urakay , Spencer Steven , Keval Aziza , McBride Jill , Young Shane , Baxter Catherine , Rasmussen Carol , Coxe Shari L. , Campos Luis , Tavackoli Shahin , Beckham Diana , Sanchez Darlynee , Basrai Karanjit , Helms Dorian , Clinton Erica , Smith Kasie , Ghitis Arnold , Cusnir Henry , Klaus Clark Mary , Cherukuri Madhavagopal V. , Scarfaru Ameta , Nash Stephen D. , Moore Jeannine , Wallace Helene , Grimm Loretta C. , Grace Anna , McElheran Kylie , Subasic Dino , Buhay Zedrick , Litvinoff Janet , Washington Tamika , Shah Deepak , Cervantes Shannon , Usher Freda , Yasser Farra , Trusevich Theodore , Garcia Ronnie L. , Wyatt Jamison , Bose Rahul , Miska Holllilyn , Spivey Traci , Wren Amy B. , Vance Katie E. , Holman Lani L. , Gibbons Pam , Eby Elaine , Shepard Sandra , Charoenthongtrakul Soratree , Snodgrass Brett , Nazem Mohammed , Keteenburg Shelly , Murthy Prathima , Prater Frederic , Rumfelt Ashley , Eizensmits Christina , Iannuzzi Lisa , Patel Pourus R. , Bergamino Clellia , McFeaters Elizabeth , Rizk Botros , Pflaum Emiljia , Kalish Danny , Ambatali Rex , Ameli Mona , Sanguinetti Delaina , Ameli Mona , Vaidya Rakesh , Blinson Karen , Doomy Lynda , Wayne Vickie , Broeders Martinus A.W. , Henrikus Dorman , Martens Fabrice M.A.C. , Kuijper Adrianus F.M. , Al-Windy Nadea , Magro Michael , Hamraoui Karim , Aksoy Ismail , Vermeiren Guy L.J. , Roeters van Lennep H.W.O. , Hoedemaker Gerard , Remmen Johannes Jacobus , Bogaard Kjell , van der Heijden Dirk , Knufman Nicole MJ , Frederiks Joost , Louwerenburg Johannes Willem , van Rossum Piet , Milhous Johannes , van der Meer Peter , van der Weerdt Arno , Breedveld Rob , Keijzers Mitran , Hermans Walter , van de Wal Ruud , Zwart Peter A.G. , van der Linden Marc M.J.M. , Zwiers Gerardus , Boswijk Dirk J. , Geert Tans Jan , van Eck Jacob , Hessen Maarten V. , Hamer Barnabas J.B. , Zoet-Nugteren Stieneke , Theunissen Lucien , van Beek E.A. , Nijmeijer Remco , Nierop Pieter R. , Linssen Gerard , Swart H.P. , Lenderink Timo , Bartels Gerard L. , den Hartog Frank , Berg van den Brian J. , van Kempen Wouter , Kentgens Susanne , Rojas Lingan Gloria M. , Peeters Martinus M. , Rojas Lingan Gloria M. , Keterberg Hilligje , Nierman Melchior , den Hollander Annemieke K. , Hoogendijk Jacqueline , Rojas Lingan Gloria M. , Voors-Pette Christine , Kose Vicdan , Viergever Peter , Yena Larysa , Syvolap Viktor , Kopytsya Mykola P. , Barna Olga , Panina Svitlana S. , Lutai Mykhailo I. , Shershnyova Oxana V. , Luzkiv Iryna , Bula Larysa S. , Zotov Sergii , Vyjhovaniuk Ivan , Lysunets Olena , Koshlia Volodymyr I. , Sydor Nataliya , Vayda Myroslava F. , Ushakov Olexiy , Rishko Mykola , Shcherbak Viktor P. , Svyshchenko Yevgeniya , Tseluyko Vira , Yagensky Andriy , Zolotaikina Viktoriia I. , Godlevska Olga , Ivanova Larysa , Koval Olena , Mitchenko Olena I. , Kardash Galyna Y. , Rudyk Yurii S. , Stanislavchuk Mykola , Ivanovych Volkov Volodymyr , Karlinskaya Olena G. , Tykhonova Susanna A. , Vatutin Nikolay , Smirnova Ganna , Kovalenko Volodymyr M. , Lizogub Viktor , Sebov Denys , Dyadyk Oleksandr , Andrievskaya Svetlana , Krasko Mykola P. , Parkhomenko Alexander N. , Horbach Lidiya , Kupnovytska Iryna G. , Pertseva Tetyana , Karpenko Oleksandr , Reshotko Dmytro , Zhurba Svitlana V. , Rudenko Leonid , Yu Zharinova Viktoriia , Shatylo Valerii B. , Karpenko Yuriy I. , Orynchak Mariya A. , Kameneva Tatiana R. , Zherlitsina Elena , Alpenidze Diana N. , Arutyunov Grigoriy P. , Baranova Elena , Bart Boris , Belenkiy Dmitriy I. , Boldueva Svetlana A. , Demchenko Elena A. , Eltishcheva Vera V. , Gofman Alexander M. , Goloshchekin Boris M. , Gennadyevich Gordeev Ivan , Gratsianskiy Nikolay , Kamalov Gadel , Khasanov Niyaz R. , Kholina Irina M. , Kobalava Zhanna D. , Kobeleva Elena V. , Konradi Alexandra O. , Kostenko Victor A. , Dmitrievich Kuimov Andrey , Ermakova Polina Y. , Malyutina Sofia K. , Panov Alexey V. , Polezhaeva Natalia V. , Reshetko Olga , Shilkina Nataliya P. , Shustov Sergey B. , Smolyarchuk Elena A. , Stryuk Raisa I. , Yurievnar Solovieva Elena , Susekov Andrey V. , Vezikova Natalia , Ivanova Svetlana N. , Petrov Alexander A. , Konstantinov Vladimir O. , Agafina Alina S. , Gurevich Victor , Zrazhevskiy Konstantin N. , Supryadkina Tatiana V. , Perepech Nikita B. , Arkhipovskiy Vadim L. , Yu Butko Dmitry , Zobenko Irina A. , Orlikova Olga V. , Mordovin Viktor , Barbarash Olga L. , Lebedeva Anastasiya , Nosov Vladimir , Averkov Oleg V. , Pavlikova Elena P. , Karpov Yuri B. , Lvovna Giorgadze Marina , Khrustalev Oleg A. , Arkhipov Mikhail , Raskina Tatiana A. , Shilko Julia V. , Samoilova Yulia , Kosmacheva Elena D. , Nedogoda Sergey V. , Coetzee Kathleen , Burgess Lesley J. , Theron F.C.R. , Ebrahim Iftikhar O. , Haasbroek Gerbrand A. , Pretorius Maria , Trokis Julien S. , Urbach Dorothea V. , Abelson Mark J. , Horak Adrian R. , Badat Aysha E. , Makotoko Ellen M. , Du Toit Theron Hendrik , Ramlachan Padaruth , Corbett Clive H. , Mitha Ismail H. , Nortje Hendrik F.M. , Jansen van Rensburg Dirkie J. , Sebastian Peter J. , Bester F.C.J. , van Zyl Louis J. , Rayner Brian L. , Błach Elżbieta , Dąbrowska Magda , Kania Grzegorz , Kelm-Warchol Agata E. , Kinasz Leszek P. , Korecki Janusz , Kruk Mariusz , Laskowska-Derlaga Ewa , Madej Andrzej , Saminski Krzysztof , Wasilewska Katarzyna , Szymkowiak Katarzyna , Wojciechowska Małgorzata , Piorowska Natalia , Dyczek Andrzej , Abhaichand Rajpal K. , Byrapaneni Ramesh B. , Hattur Basavanagowdappa , Bhaskara Rao Malipeddi , Ghaisas Nitin , Shankar Kadam Sujit , Gupta Jugal B. , Jayadev Santhosh M. , Kothiwale V.A. , Mathur Atul , Bhaskar Vijay , Aluri Ravi K. , Ponangi Udaya P. , Sarna Mukesh K. , Sathe Sunil , Sharma Manish K. , Singh Sawhney Jilendra Pal , Keshavamurthy Chakrabhavi B. , Srinivas Arun , Thacker Hemant P. , Sharda A. , Joseph Johny , Dwivedi Sunil , Mohan Viswanathan , Premchand Rajendra K. , Bedard Jacques , Bergeron Jean , Collette Ronald , Crowley David , Dumas Richard , Henein Sam , Moran Geoff , O’Mahony William F. , O’Mahony Michael , Chan Sammy , Sherman Mark H. , Wong Graham C. , Carlson Brian D. , Gupta Milan K. , Borts David , Peterson Sean R. , Chilvers Martyn , Kelly Allan J. , Gregoire Jean C. , Kouz Simon , Rodés Cabau Josep , Andor Minodora , Cinteza Mircea , Ciudin Radu , Cojan Radu I. , Darabont Roxana O. , Dumitrascu Dan-Lucian , Fierbinteanu-Braticievici Carmen , Fruntelata Ana Gabriela , Militaru Constantin , Minescu Bogdon E. , Luminita Serban Doina , Mitu Florin , Nastase Melicovici Dorel , Petrascu Ovidiu , Pirvu Octavian M. , Podoleanu Cristian , Pop Calin , Stanescu-Cioranu Rodica-Valentina V. , Tase Adrian , Voiculet Cristina , Aroney Constantine N. , Dart Anthony M. , Davis Timothy , Kostner Karam , O’Neal David N. , Purnell Peter W. , Singh Bhuwanendu B. , Sullivan David R. , Thompson Peter , Watts Gerald F. , Blenkhorn Adam F. , Amerena John V. , Samie Rafeeq , Hendriks Randall , Proietto Joseph , Petrovsky Nikolai , Whelan Alan , Colquhoun David , Scott Russell S. , Young Simon C. , Pegg Tammy , Wilson Samuel JS , Hamer Andrew W. , Luke Richard A. , Hart Hamish H. , Devlin Gerard P. , Wilkins Gerard T. , Ternouth Ian F. , Nandra Samraj , Loeprich Bruno S. , McGrath Nicole , Tie Stuart L. , Bos Rob J. , Wils Alexandra , Jacobs Tamara , Badings Erik A. , Ebels-Tuinbeek Lillian A. , Scholten Mayke L. , Bayraktar-Verver Esther , Zweers Debby , Schiks Manoek , Kalkman Carolien , Tiemes Tineke , Mulderij Jeanette , Hermans Walter , Dabrowska Katarzyna , Wijnakker Wilma , Van de Loo Riny , de Graauw Jeanne , Reijnierse Giny , van der Zeijst Mirjam , Scholten Mariska , Hofmeijer Henk R. , van Dijk-van der Zanden Antoinette , van Belle Dineke J. , Van Es Jan , Van Buchem Gera , Zijda Wendy , Verheij Harald , Oldenhof-Janssen Linnea , Bader Martina , Löwik Marije , Stuij Sandra , Vantrimpont Pascal , van Aken Krista , Hamilton Karen , van der Weerdt Arno , Blömer Han , van Laerhoven Gabriela , Tukkie Raymond , Janssen Maarten , Verdel Gerard , Funke Küpper Jon , van Vlies Bob , Kalkman Caroline , Vooges Joke , Vermaas Marinella , de Graauw Jeanne , Van de Loo Riny , Langenberg Rachel , Haenen Niek , Smeets Frans , Scheepmaker Arko , Grosfeld Marcel , Van Lieshout Ilvy , van den Berg Marleen , Wittekoek Marian , Mol Petra , Stapel Antionette , Sierevogel Margaretha , van der Ven Nancy , Berkelmans Annemiek , Viergever Eric , Kramer Hanneke , Engelen Wilma , Houwelingen Karen V. , Wildbergh Thierry X. , Mosterd Arend , Hobé-Rap Coriet , van Doorn Marjan , Bunschoten Petra , Freericks Michel , Emans Mireille , Den Boer-Penning Petra , Verlek Els , Freericks Christine , de Nooijer Cornelis , Welten Christina , Groenenberg Ingrid , van der Horst Claudia , Vonk Esther , Tjeerdsma Geert , Jochemsen Gerard M. , van Daalen Corinne , Danse Ingrid Y. , Kuipers Lucy , Pieterse Anke , Oomen Antonius , de Waard Daan , Jan Flu Willem , Kromhout Zusan , Van der Bij Petra , Feld Rob , Hessels-Linnemeijer Brigitta , Lardinois Rob , Posma Jan L. , Aukema-Wouda Zwanette R. , Hendriks-van Woerden Marjolijn , van Wijk Desiree , Beelen Driek P. , Hendriks Ingrid H. , Jonker Jan J. , Schipperen Stefanie , Köse Vicdan , Rojas Gloria , Goedhart Linda , van Meurs Hanneke , Langenberg Rachel , Rijssemus Jacqueline , Hoogendijk Jacqueline , Swinkels-Diepenmaat Lindy , van Kempen Wouter , de Louw-Jansen Marloes , Bierens-Peters Dominique , van Kempen Willem W. , Wittekoek Marianne E. , Agous Irmaina , Schenk Geert , van Kempen Willem W. , Wittekoek Janneke , Cox Kevin , Julia Deborah F. , Jonker Jan J.C. , Janssen Roel , van Kempen Willem W. , Wittekoek Marianne E. , Nierman Melchor , Katerberg Hilligje , Jonker Jan J.C. , van der Haar Irene , Van Kempen Willem W. , van Mesdag Taco , Wittekoek Janneke , Jonker Jan J.C. , Alvarez Costa Leyda M. , Schensema Manon , Zweekhorst Salomé , Swinkels-Diepenmaat Lindy , Schipperen Stefanie , van Kempen Willem W. , Font Julia Deborah , Jonker Jan J.C. , Hanewinckel Lauri , Olsthoorn Joyce , Berends Johan C. , van der Spek Arie C. , van der Berg Roy , Timmermann Rob J. , Boerema Ingrid , Mudruk Iryna , Khrystoforova Anna , Kyselov Serhii , Hilova Yaroslava V. , Logoida Pavlo , Logoida Pavlo , Sanina Nataliia A. , Golikova Ilona P. , Nemchyna Olena O. , Golikova Ilona P. , Golikova Ilona P. , Isaichikov Ivan I. , Potapova Olga B. , Gura Iurii V. , Berestetska Larysa , Kulianda Olena O. , Tantsura Oleksandr , Kulbachuk Oleksandr S. , Petsentiy Volodymyr , Biskub Ihor , Biskub Ihor , Handych Tetyana , Lagkuti Oleg , Gagarina Alyna , Chendey Taras , Bilonko Oksana F. , Matova Olena , Bezrodna Larysa , Yarynkina Olena , Ovdiienko Tetiana , Randchenko Volodymyr , Mospan Maryna , Ovdiienko Tetiana , Butko Olena , Romanenko Olga , Pavelko Mykhailo , Sichkaruk Iryna , Lazareva Svitlana O. , Kudryk Olena A. , Koltsun Inessa M. , Koltsun Inessa M. , Magdalits Tetiana , Zadorozhniy Sergei , Kompaniiets Kira , Ivanov Andrii , Romanenko Sergiy , Kaplan Pavlo , Romanov Vadym Y. , Mykytyuk Oksana P. , Zaitseva Nataliia S. , Pyvovar Sergiy N. , Burdeuna Lyudmyla , Serdobinska Emerita , Shevchenko Tatiana I. , Ivanytskyi Igor I. , Ivanytskyi Igor I. , Ivanytskyi Igor I. , Khyzhnyak Olena V. , Smirnova Ganna , Kalinkina Nataliya , Keting Olena , Sklyanna Olena , Kashanska Olga , Shevelok Anna , Khristichenko Marina , Titov Ievgenii Y. , Oleksander Danilenko O. , Polenova Nataliia S. , Altunina Nataliia , Kororaieva Viktoriia , Zborovskiy Stanislav , Kholopov Leonid , Suliman Iurii , Lukashenko Lanna , Shvaykin Stanislav , Glavatskiy Olexandr M. , Sychov Roman O. , Kulynych Roman L. , Skarzhevskyi Oleksandr A. , Dovgan Nataliia V. , Horbach Marta , Cherkasova Olga , Tyshchenko Iryna , Todoriuk Liudmyla , Kizim Svitlana , Brodi Nataliia , Ivanko Oleksandr , Garbarchuk Olga , Alieksieieva Liudmyla , Shandra Tetiana L. , Beregova Olena , Bodretska Larisa An , Naskalova Svitlana S. , Antoniuk-Shcheglova Ivanna A. , Bondarenko Olena V. , Andreeva Natalia G. , Vakalyuk Iryna I. , Chovganyuk Olha S. , Artemenko Nataliya R. , Maltsev Kiril A. , Kalishevich Natalia , Kondratyeva Natalia G. , Nikitina Svetlana A. , Martjanova Maria V. , Sokolova Anna V. , Dragunov Dmitrii O. , Kolesnik Olga , Larina Vera , Tsygankova Oxana V. , Ivanova Maria , Karpov Illia A. , Aronova Elena M. , Vedernikova Ekaterina S. , Lubinskaya Ekaterina I. , Burak Taras Y. , Skichko Sergey I. , Rasulev Farhad , Soldatova Ekaterina B. , Fenin Alexander L. , Laptev Ilya I. , Luchinkina Elena E. , Akatov Alexandr , Polenova Natalia V. , Slavina Natalia N. , Korovnika Irina N. , Yu Prochorova Marina , Shakirova Regina , Andreicheva Elena N. , Krasnova Olga A. , Lobzhanidze Tinatin V. , Dmitrova Tatiana B. , Stakhiv Viktoriya V. , Pechatnikova Maria I. , Panova Alexandra V. , Tipikina Maria Y. , Rotar Oxana P. , Bokovin Nikolay A. , Karabalieva Saule K. , Tumarov Farid Y. , Vasileva Elena V. , Gennadevna Lozhkina Natalya , Filippova Ekaterina V. , Sharkaeva Alisa I. , Filippova Deilik Ekanerina V. , Yu Tolkacheva Natalia , Domracheva Elena N. , Ryabikov Andrey N. , Abesadze Inga T. , Alugishvili Marianna Z. , Nikolaeva Elena P. , Smirnova Nadezda V. , Rodionova Valentina I. , Dolovstaya Polina V. , Yunonin Igor E. , Kadin Sergey V. , Sveklina Tatyana S. , Bushmanova Anna V. , Bushmanova Anna V. , Barkova Elena L. , Gomova Irina S. , Brytkova Yana V. , Ivanova Tatiana B. , Zubareva Marina Y. , Skopets Inga , Galashevskaya Lybov A. , Butinskaya Emilia D. , Gusarova Olga G. , Kalishevich Natalia B. , Pavlova Yana R. , Serebrenitskaya Marianna P , Grygorieva Vitalina F. , Kuchaeva Gulnara R. , Vasileva Inna A. , Ospanova Gulnara I. , Vahrusheva Yulia V. , Semenova Irina A. , Mikhailova Irina E.E. , Kvasova Olga O. , Shurygina Valeria D. , Rivin Alexey E. , Savelyev Alexey O. , Savelyev Alexey A. , Milyaeva Olesya O. , Lapshina Nadezhda N. , Lantsova Ninel A. , Alexandrov Pavel V. , Orlikov Evgeniy A. , Falkovskaya Alla , Ripp Tatiana , Triss Sergei , Pekarskiy Stanislav , Ekaterina Sitkova , Zhuravleva Evgeniya N. , Perova Olga , Kovaleva Galina , Koroleva Liubov , Koroleva Liubov , Mishchenko Lydia , Garshin Boris P. , Kutuzova Svetlana A. , Provotorova Lyudmila I. , Zadvorny Igor P. , Okhapkina Olga V. , Khrustalev Anatoly O. , Suvorova Tatiana , Shaf Elena S. , Vershinina Varvara A. , Kozulin Andrey A. , Oleynik Oxana A. , Martynova Irina Y. , Kizhvatova Natalia V. , Salasyuk Alla S. , Tsoma Vera V. , Ledyaeva Alla A. , Chumachek Elena V. , Blignaut S.C. , Alexander Tersia Y. , Du Plessis Chano , Govender Thirumani , Du Toit Samatha M. , Motala Leya , Gassiep Areesh , Naude (Smit) Christina , Terblanche Marli , Snoer (Kruger) Marlien , Pillay Berenice , Basson De Vries , Corbett Clive H. , Theron Marisa E. , Fouche Bianca , Coetzee Mareli E. , Odendall Pieter , Van Wijk Frederik H. , Conradie Anna-Mari , Van der Westhuizen Trudie , Tredoux Carine , Mookdam Mohamed S. , Van der Merwe Andie J. , Snyman Karin , Smal Gerda , De Jager Yvonne , Mabin Thomas A. , King Annusca , Henley Lindy L. , Zwane Brenda M. , Robinson Jane , Karsten Marinda , Page Andonia M. , Nsabiyumva Valerie , Krahenbuhl Charmaine , Patel Jaiprakash D. , Motala Yunus E. , Dawood Ayesha , Koza Nondumiso B. , Peters Lenore M.S. , Ramlachan Shavashni , Bodenstein Wilhelm J. , Roux Pierre , Fouche Lizelle , Boshoff Cecilia M. , Mitha Haroon M. , Khan Fathima , Cyster Henry P. , Cyster Helen , Wessels E. C. , Jacobs Florence J. , Sebastian Melanie A. , Sebastian Deborah A. , Mahomed Nadia , Immink Ignatius P. , Cotzee Celia , Cronje Tanja , Roscher Madele , Le Roux Maria , Trinder Yvonne A. , Wnętrzak-Michalska Renata , Piszczek Magdalena , Piela Andrzej , Czernecka Ewa , Knychas Dorota , Walczak Alina , Gładysz Izabella , Filas Katarzyna , Kiluk Ewelina , Świgło Krzysztof , Jędrzejczyk Iwona , Łuczyńska Kamila , Tymendorf Katarzyna , Piesiewicz Wojciech , Kinasz Wojciech L. , Samborski Stefan , Bartuś Ilona , Latocha Korecka Gramzyna , Gulaj Ewa , Sopa Jolanta , Derlaga Bogusław , Baisiak Marcin , Kowalisko Allicia , Stainszewska-Marasazlek Edyta , Szafran Bartosz , Swiatkiewicz Malgorzata , Racewicz Artur , Grycel Sławomir , Supronik Jerzy , Walendziuk Sylwia , Tarantowicz Magdalena , Stasiak Agata , Sidorowicz-Białynicka Anna , Dwojak Marek , Jaźwińska-Tarnawska Ewa , Kupczyk Katarzyna , Martowska Kamila , Kulon Kamila , Gajda Katarzyna , Wilson Bivin , Velusamy Krithika , Sadhiq Swaidha S. , Siddeshi Bhavani , Bhanukumar M. , Srivatsav Abhishek , Ramesh Madhan , Harsha Chalasani Sri , Johnson Mini , Gopu Prashanth , George Jeesa , Reddy Sowmya , Thara Eleena Swetha Tessy , Rao Kodem Damodara , Nakkella Haritha N. , Kumari Mandula Padma , Kumar Vuriya Anjan , Rajana Syamala , Kale Aruna , Rajeev Tiwari , Jain Raina , Jain Vipin , Mandayam Adhyapak Srilakshmi , Sheeba Lumin , C R Uma , R Ramya , Kulkarni Aditya V. , Ganachari M.S. , Sambrekar Ruma , Bilal Mohammad , Chakravarthy Kalyan , Badhavath Ravi , Kumar Sravan , Simhadri Meenakshi , Salamuddin Farooque , Prasad Venkat , Dwivedi Vivek , Sarna Sudha , Arora Tilak , Chawla Deepak , Sathe Archana , Gayatree Chaware , Nanda Ajeet , Avtar Ram , Sharma Jyoti , P S Vaibhavi , D Sasirekha , Kobbajji Deepthi , Ningappa Ramya , Shree Shwetha , K Chandrashekar , M R Nandini , S Sowjanya , I G Devika , N Yashaswini , G Sonika , L Rathna , R Priyanka , Shrimanker Rupal J. , Vinutha Reddy Lakshmi , Sumathi K. , Devi Babitha , Naik Bina N. , Manjunath Rohini , Ashok Rajeshwari , Kunjumon Tony V. , Thomas Jesline , Samdhani Shaik , Selvam Kasthuri , Subramani Poongothai , Parthasarathy Nandakumar , Bohra Nirmal K. , Gatla Anvesh K. , Horbatuk Cheryl , Sills Julie , Davey E B. , Paramonczyk Liz , Racanelli Olga , Crowley David , Strybosch Sandy , Belanger Andre , Palardy Jean , Schiffrin Alicia , Gauthier Sylvie , Kalyniuk Norman , Whatley Shawn D. , Lappala Heather , Patel Grishma , Reeve Matthew , Moran Catherine , Everitt Jody , Ferrari Teresa , Bouffard Christine , Frohlich Jirir , Francis Gordon , Mancini John , Bondy Gregory , DeAngelis Debbie , Fulton Patricia , Blank David W. , Lombardo Angela , Roy Mylène , Chow Jackie , Fox Hyman , Grootendorst William J. , Hutchinson Angela , Chan Sharon M. , Fitzgerald Christie , Ferrari Teresa , Wilkins Lynn , Raymond Rebecca L. , Reyes Arlene , Marc André Lavoie , Fortin Denis , Ouimet Hélène , Tôn-Nu Thanh-Thao , Dussureault Martine , Blain Marie-Hélène , Roy Madeleine , Kopajko Nathalie , Fleury Chantal , Maheux Karine , Ciobotaru Gabriela Valentina , Constantinescu Maria C. , Gherghinescu Carmen-Lucia , Avram Ana-Maria , Manitiu Ioan , Cojan Radu I. , Pirvu Octavian M. , Sinpetrean Aura , Pop Lucian , Lupu Delia , Usvat Radu , Petrisor Ana , Dumitru Nicoleta , Moruju Camelia , Gheorghita Adelina , Mitu Magda V. , Macarie Cosmin , Pop Ana Maria , Diaconu Maria-Catalina , Grancea Iulia , Cosma Mihaela , Cosma Mihaela , Crisan Mihaela , Herron Elizabeth , Dart Anthony M. , Nestel Paul , Kay Sally B. , Carter Kaye S. , Badshah Imran , Makepeace Ashley , Drinkwater Jocelyn , England Michelle , Rafei Azette , Patterson Kylie , Jenkins Alicia , McAuley Sybil , Kent Sue M. , Vibert Joy E. , Perrett Leonie , David Thomas , Kaye Samantha L. , O’Connor Monika , Perera Nimalie J. , Lai Nicole T. , Kearins Kerry A. , Dicamillo Christinia , Anderson Heather , Ferguson Louise , Radtke Sharon D. , Thamarappillil Charles T. , Boys Janice M. , Long Anita K. , Shanahan Toni , Nyguyen Michael , Forrest Nicole , Tulloch Gill , Greenwell Della , Price Sarah L. , Tint Aye N. , Sumithran Priya K. , Debreceni Tamara L. , Walker Lisa , Caruana Mary , Edwards Kira , Stathopoulos Maria , Haywood Cilla , Sajkov Dimitar , Pringle Sharen , Tabner Anne , Bartolay Kathrina , Abeyratne Chamindi , Bragg Kylie , Mulhern Patrick , Purnell Peter , Hendriks Randall , Tulloch Gill , Williams Lyn , Hamlyn Jane , Connelly Aurelia , Hoffman Jan , Bailey Samantha , Kerr Jane , Morrison Zarnia , Maeder Sarah , McEwan Roberta , Kunasekera Prasanna , McGregor Patrice , Young Jo , Berry Sharon , Cutfield Rick , Choe Michelle , McNamara Catherine , Shergill Narrinder K. , Crone Petra , Williams Miles G. , Dyson Keith , Schmid Diana H. , Doak Audrey C. , Spooner Melissa , Edwards Colin , Turner Anne , McAnnalley Grainne M. , Fisher Raewyn A. , Hamilton Fraser B. , Friedlander Denis H. , Kirk Melissa R. , Scales Jayne E. , McLelland Marguerite A. , Dalman Neelam A. , Vickers Cathy E. , Jackson Carolyn , Coleman Wendy , Garden Phillip I. , Arnold Wendy F. 
Published: October 2021

Background:

Despite advances in surgery and pharmacotherapy, there remains significant residual ischemic risk after coronary artery bypass grafting surgery.

Methods:

In REDUCE-IT (Reduction of Cardiovascular Events With Icosapent Ethyl–Intervention Trial), a multicenter, placebo-controlled, double-blind trial, statin-treated patients with controlled low-density lipoprotein cholesterol and mild to moderate hypertriglyceridemia were randomized to 4 g daily of icosapent ethyl or placebo. They experienced a 25% reduction in risk of a primary efficacy end point (composite of cardiovascular death, myocardial infarction, stroke, coronary revascularization, or hospitalization for unstable angina) and a 26% reduction in risk of a key secondary efficacy end point (composite of cardiovascular death, myocardial infarction, or stroke) when compared with placebo. The current analysis reports on the subgroup of patients from the trial with a history of coronary artery bypass grafting.

Results:

Of the 8179 patients randomized in REDUCE-IT, a total of 1837 (22.5%) had a history of coronary artery bypass grafting, with 897 patients randomized to icosapent ethyl and 940 to placebo. Baseline characteristics were similar between treatment groups. Randomization to icosapent ethyl was associated with a significant reduction in the primary end point (hazard ratio [HR], 0.76 [95% CI, 0.63–0.92];
P
=0.004), in the key secondary end point (HR, 0.69 [95% CI, 0.56–0.87];
P
=0.001), and in total (first plus subsequent or recurrent) ischemic events (rate ratio, 0.64 [95% CI, 0.50–0.81];
P
=0.0002) compared with placebo. This yielded an absolute risk reduction of 6.2% (95% CI, 2.3%–10.2%) in first events, with a number needed to treat of 16 (95% CI, 10–44) during a median follow-up time of 4.8 years. Safety findings were similar to the overall study: beyond an increased rate of atrial fibrillation/flutter requiring hospitalization for at least 24 hours (5.0% vs 3.1%;
P
=0.03) and a nonsignificant increase in bleeding, occurrences of adverse events were comparable between groups.

Conclusions:

In REDUCE-IT patients with a history of coronary artery bypass grafting, treatment with icosapent ethyl was associated with significant reductions in first and recurrent ischemic events.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01492361.