bluuebunny/crossref_metadata_2025 huggingface dataset:
CARING: Cannula for Alleviation of Retinal Injury Caused by Needle Fluidic Gashing
Authors: Rickels Kaersti L. , Gunderman Anthony L. , McLellan Mattie S. , Shamim Muhammad M. , Sanford Joseph A. , Uwaydat Sami H.
Published: July 2024

Infusion-related iatrogenic retinal breaks (IRBs) are a significant complication in vitrectomies, particularly when smaller-gauge cannulas are used during fluid infusion. Using two-dimensional finite element analysis (FEA), we analyzed forces exerted on the retina from different cannulas: traditional 25-gauge, 20-gauge, 23-gauge, and 27-gauge, then investigated four alternative new cannula designs: (A) oblique orifices, (B) external obstruction, (C) side ports, and (D) perpendicular orifices. The analysis revealed that the standard 25-gauge cannula had a force of 0.546 milli-Newtons (mN). Optimized cannulas demonstrated decreased forces: 0.072 mN (A), 0.266 mN (B), 0.417 mN (C), and 0.117 mN (D). While all the designs decrease fluid jet force, each has unique challenges: Design A may complicate manufacturing, B requires unique attachment techniques, C could misdirect fluid toward the lens and peripheral retina, and D requires a sealed trocar/cannula design to prevent unwanted fluid ejection. These four innovative cannula designs, identified with detailed engineering simulations, provide promising strategies to reduce the risk of IRBs during vitrectomy, bridging the gap between engineering insights and clinical application.
Time-Dependent Shifts in Intestinal Bacteriome, Klebsiella Colonization and Incidence of Antibiotic-Resistance Genes after Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Goloshchapov Oleg V. , Chukhlovin Alexey B. , Polev Dmitrii E. , Eismont Yury A. , Bug Dmitry S. , Kusakin Alexey V. , Kosarev Oleg V. , Klementeva Ruslana V. , Gostev Vladimir V. , Ageevets Vladimir A. , Volkov Nikita P. , Ipatova Anastasia S. , Moiseev Ivan S. , Spiridonova Anna A. , Sidorenko Sergey V. , Kulagin Alexander D.
Published: July 2024

Dose-intensive cytostatic therapy and antibiotic treatment in allogeneic hematopoietic stem cell transplantation (allo-HSCT) cause severe abnormalities in a composition of gut microbiota as well as the emergence of antibiotic resistance. The data on the longitudinal recovery of major bacterial phyla and the expansion of genes associated with antibiotic resistance are limited. We collected regular stool samples during the first year after allo-HSCT from 12 adult patients with oncohematological disorders after allo-HSCT and performed 16SrRNA sequencing, multiplex PCR, conventional bacteriology and CHROMagar testing. We observed a decline in Shannon microbiota diversity index as early as day 0 of allo-HSCT (p = 0.034) before any administration of antibiotics, which persisted up to 1 year after transplantation, when the Shannon index returned to pre-transplant levels (p = 0.91). The study confirmed the previously shown decline in Bacillota (Firmicutes) genera and the expansion of E. coli/Shigella, Klebsiella and Enterococci. The recovery of Firmicutes was slower than that of other phyla and occurred only a year post-transplant. A positive correlation was observed between the expansion of E. coli/Shigella genera and blaKPC, blaCTX-M-1 and blaTEM (p < 0.001), Klebsiella spp. and blaOXA-48-like, blaNDM, blaCTX-M-1, blaTEM, and blaSHV (p < 0.001), Pseudomonas spp. and blaNDM (p = 0.002), Enterococcus spp. and blaOXA-48-like, blaNDM, blaCTX-M-1, blaSHV (p < 0.01). The correlation was observed between the expansion of Enterobacterales and and carbapenemase-positive CHROMagar samples (p < 0.001). Samples positive for carbapenem-resitant bacteria were at their maximum levels on day +30, and were gradually diminishing one year after allo-HSCT. From day +30 to +60, all isolated K. pneumoniae strains in fecal samples proved to be resistant to the main antibiotic groups (carbapenems, aminoglycosides, fluoroquinolones, third-generation cephalosporins). One year after HSCT, we documented the spontaneous decolonization of K. pneumoniae. The sensitivity of molecular biology techniques in the search for total and antibiotic-resistant Klebsiella seems to be superior to common bacteriological cultures. Future studies should be focused on searching for novel approaches to the efficient reconstitution and/or maintenance of strictly anaerobic microbiota in oncological patients.
Carnosic Acid (CA) Induces a Brown Fat-like Phenotype, Increases Mitochondrial Biogenesis, and Activates AMPK in 3T3-L1 Adipocytes
Authors: Vlavcheski Filip , MacPherson Rebecca E. K. , Fajardo Val , Sze Newman , Tsiani Evangelia
Published: July 2024

Adipose tissue plays a crucial role in regulating metabolic homeostasis, and its dysfunction in obesity leads to insulin resistance and type 2 diabetes (T2D). White adipose tissue (WAT) primarily stores energy as lipids, while brown adipose tissue (BAT) regulates thermogenesis by dissipating energy as heat. The process of browning involves the transdifferentiation of WAT into brown-like or beige adipocytes, which exhibit a similar phenotype as BAT. The browning of WAT is an attractive approach against obesity and T2D, and the activation of the energy sensor AMP-activated protein kinase (AMPK) has been shown to play a role in browning. Carnosic acid (CA), a polyphenolic diterpene, found in many plants including rosemary, is reported to possess potent antioxidant, anti-inflammatory, and anti-hyperglycemic properties. The limited evidence available indicates that CA activates AMPK and may have anti-obesity and antidiabetic potential; however, the effects in adipocyte browning remain largely unexplored. This study aimed to examine the effects of CA on the markers of adipocyte browning. The treatment of 3T3L1 adipocytes with CA activated AMPK, reduced lipid accumulation, and increased the expression of browning protein markers (UCP-1, PGC-1α, PRDM16, and TFAM) and mitochondrial biogenesis. The use of compound C, an AMPK inhibitor, significantly attenuated the effects of CA, indicating AMPK involvement. These studies demonstrate that CA can activate AMPK and stimulate the browning of white adipocytes. Future animal and human studies are required to examine the effects of CA in vivo.
Apoptotic Induction by Biosynthesized Gold Nanoparticles Using Phormidesmis communis Strain AB_11_10 against Osteosarcoma Cancer
Authors: Hamida Reham Samir , AlMotwaa Sahar M. , Al-Otaibi Waad A. , Alqhtani Haifa A. , Ali Mohamed Abdelaal , Bin-Meferij Mashael Mohammed
Published: July 2024

Phormidesmis communis strain AB_11_10 was isolated and identified using microscopy and 16s rRNA sequencing, and its phytochemical constituents were determined using liquid chromatography-quadrupole time-of-flight mass spectrometry. The isolate had a segmented filamentous shape with a blue-green color. Many biomolecules, including organic compounds, amino acids, and fatty acids, were detected. P. communis strain AB_11_10 was used to synthesize gold nanoparticles (Ph-AuNPs) by adjusting the optimum reaction conditions. The concentration, algal/precursor ratio, temperature, reaction time, and pH significantly influenced the synthesis of the Ph-AuNPs. Mixing 1 mL of 0.5 mM of HAuCl4 with 1 mL of algal extract and exposing the mixture to 100 °C for 30 min at pH 5.6 were the optimum conditions for the biosynthesis of Ph-AuNPs at a wavelength of 524.5 nm. The Ph-AuNPs were characterized using TEM, SEM, EDX, and mapping Zeta sizer and FTIR. The Ph-AuNPs had quasi-spherical to triangular shapes with an average diameter of 9.6 ± 4.3 nm. Ph-AuNPs composed of 76.10 ± 3.14% of Au and trace amounts of carbon and oxygen were detected, indicating that the P. communis strain AB_11_10 successfully synthesized Ph-AuNPs. The hydrodynamic diameter of the Ph-AuNPs was 28.5 nm, and their potential charge was −17.7 mV. O-H, N-H, C=C, N-O, C-H, and C-O were coated onto the surfaces of the Ph-AuNPs. These groups correspond to algal phytochemicals, which may have been the main reducing and stabilizing substances during the Ph-AuNP synthesis. The therapeutic activity of the Ph-AuNPs against osteosarcoma cancers was examined in MG-63 and SAOS-2 cell lines, while their biocompatibility was tested against Vero cell lines using a sulforhodamine B assay. The Ph-AuNPs had potent antitumor activity against the MG-63 and SAOS-2 cells, with a low toxicity toward Vero cells. Flow cytometry and cell cycle arrest analyses revealed that the Ph-AuNPs enhanced the apoptotic pathway and arrested the cell cycle in the MG-63 and SAOS-2 cells. P. communis strain AB_11_10 provides a new source to synthesize small, stable, and biocompatible AuNPs that act as apoptotic enhancers in osteosarcoma.
Diabetes and Heart Failure: A Literature Review, Reflection and Outlook
Authors: Li Xiya , Zhou Xiaoyang , Gao Ling
Published: July 2024

Heart failure (HF) is a complex clinical syndrome caused by structural or functional dysfunction of the ventricular filling or blood supply. Diabetes mellitus (DM) is an independent predictor of mortality for HF. The increase in prevalence, co-morbidity and hospitalization rates of both DM and HF has further fueled the possibility of overlapping disease pathology between the two. For decades, antidiabetic drugs that are known to definitively increase the risk of HF are the thiazolidinediones (TZDs) and saxagliptin in the dipeptidyl peptidase-4 (DPP-4) inhibitor, and insulin, which causes sodium and water retention, and whether metformin is effective or safe for HF is not clear. Notably, sodium-glucose transporter 2 (SGLT2) inhibitors and partial glucagon-like peptide-1 receptor agonists (GLP-1 RA) all achieved positive results for HF endpoints, with SGLT2 inhibitors in particular significantly reducing the composite endpoint of cardiovascular mortality and hospitalization for heart failure (HHF). Further understanding of the mutual pathophysiological mechanisms between HF and DM may facilitate the detection of novel therapeutic targets to improve the clinical outcome. This review focuses on the association between HF and DM, emphasizing the efficacy and safety of antidiabetic drugs and HF treatment. In addition, recent therapeutic advances in HF and the important mechanisms by which SGLT2 inhibitors/mineralocorticoid receptor antagonist (MRA)/vericiguat contribute to the benefits of HF are summarized.
Effect of Various Carbon Electrodes on MIP-Based Sensing Proteins Using Poly(Scopoletin): A Case Study of Ferritin
Authors: Yarman Aysu
Published: July 2024

Sensitivity in the sub-nanomolar concentration region is required to determine important protein biomarkers, e.g., ferritin. As a prerequisite for high sensitivity, in this paper, the affinity of the functional monomer to the macromolecular target ferritin in solution was compared with the value for the respective molecularly imprinted polymer (MIP)-based electrodes, and the influence of various surface modifications of the electrode was investigated. The analytical performance of ferritin sensing was investigated using three different carbon electrodes (screen-printed carbon electrodes, single-walled-carbon-nanotube-modified screen-printed carbon electrodes, and glassy carbon electrodes) covered with a scopoletin-based MIP layer. Regardless of the electrode type, the template molecule ferritin was mixed with the functional monomer scopoletin, and electropolymerization was conducted using multistep amperometry. All stages of MIP preparation were followed by evaluating the diffusional permeability of the redox marker ferricyanide/ferrocyanide through the polymer layer by differential pulse voltammetry. The best results were obtained with glassy carbon electrodes. The MIP sensor responded up to 0.5 µM linearly with a Kd of 0.30 µM. Similar results were also obtained in solution upon the interaction of scopoletin and ferritin using fluorescence spectroscopy, resulting in the quenching of the scopoletin signal, with a calculated Kd of 0.81 µM. Moreover, the binding of 1 µM ferritin led to 49.6% suppression, whereas human serum albumin caused 8.6% suppression.
Development of Innovative Biocomposites with Collagen, Keratin and Hydroxyapatite for Bone Tissue Engineering
Authors: Popescu Florin , Titorencu Irina , Albu Kaya Madalina , Miculescu Florin , Tutuianu Raluca , Coman Alina Elena , Danila Elena , Marin Minodora Maria , Ancuta Diana-Larisa , Coman Cristin , Barbilian Adrian
Published: July 2024

This study follows the process for the development of an innovative biomimetic composite derived from bovine collagen with keratin, with hydroxyapatite being hybridized into its architecture, and it builds a comprehensive evaluation of the composite’s characteristics. The novel biomimetic materials are tailored with special traits to be achieved for the repair of osteochondral defects (OCDs). The purpose of the present research is to create a reliable effective alternative to existing bone graft materials while leveraging the intrinsic properties of the components for enhanced osteoinduction and integration. The composites were characterized based on their morphological properties, including water absorption, through scanning electron microscopy (SEM), and their structural properties were characterized by Fourier-Transform Infrared Spectroscopy (FTIR). Biological performance was assessed in vitro using human bone marrow mesenchymal stem cells (BMSCs), focusing on cytotoxicity, cell viability, and the ability to support cell colonization with forthcoming results. This in vivo study illustrates the real potential that this class of novel composites exhibits in regard to bone and cartilage tissue engineering and encourages further exploration and development for future clinical applications.
Modeling and Analysis of Environmental Electromagnetic Interference in Multiple-Channel Neural Recording Systems for High Common-Mode Interference Rejection Performance
Authors: Wang Gang , You Changhua , Feng Chengcong , Yao Wenliang , Zhao Zhengtuo , Xue Ning , Yao Lei
Published: July 2024

Environmental electromagnetic interference (EMI) has always been a major interference source for multiple-channel neural recording systems, and little theoretical work has been attempted to address it. In this paper, equivalent circuit models are proposed to model both electromagnetic interference sources and neural signals in such systems, and analysis has been performed to generate the design guidelines for neural probes and the subsequent recording circuit towards higher common-mode interference (CMI) rejection performance while maintaining the recorded neural action potential (AP) signal quality. In vivo animal experiments with a configurable 32-channel neural recording system are carried out to validate the proposed models and design guidelines. The results show the power spectral density (PSD) of environmental 50 Hz EMI interference is reduced by three orders from 4.43 × 10−3 V2/Hz to 4.04 × 10−6 V2/Hz without affecting the recorded AP signal quality in an unshielded experiment environment.
Neurohabilitation of Cognitive Functions in Pediatric Epilepsy Patients through LEGO®-Based Therapy
Authors: Zaldumbide-Alcocer Flor Lorena , Labra-Ruiz Norma Angélica , Carbó-Godinez Abril Astrid , Ruíz-García Matilde , Mendoza-Torreblanca Julieta Griselda , Naranjo-Albarrán Lizbeth , Cárdenas-Rodríguez Noemí , Valenzuela-Alarcón Erika , Espinosa-Garamendi Eduardo
Published: July 2024

In the pediatric population, epilepsy is one of the most common neurological disorders that often results in cognitive dysfunction. It affects patients’ life quality by limiting academic performance and self-esteem and increasing social rejection. There are several interventions for the neurohabilitation of cognitive impairment, including LEGO®-based therapy (LEGO® B-T), which promotes neuronal connectivity and cortical plasticity through the use of assembly sets and robotic programming. Therefore, the aim of this study was to analyze the effect of LEGO® B-T on cognitive processes in pediatric patients with epilepsy. Eligible patients were identified; in the treatment group, an initial evaluation was performed with the NEUROPSI and BANFE-2 neuropsychological tests. Then, the interventions were performed once a week, and a final test was performed. In the control group, after the initial evaluation, the final evaluation was performed. An overall improvement was observed in the LEGO® B-T patients, with a significant increase in BANFE-2 scores in the orbitomedial, anterior prefrontal, and dorsolateral areas. In addition, in the gain score analysis, the orbitomedial and memory scores were significantly different from the control group. LEGO® B-T neurohabilitation is a remarkable option for epilepsy patients, who are motivated when they observe improvements.
Frontoparietal Response to Working Memory Load Mediates the Association between Sleep Duration and Cognitive Function in Children
Authors: Yan Jie , Bai Haolei , Sun Yuqing , Sun Xueqi , Hu Zhian , Liu Bing , He Chao , Zhang Xiaolong
Published: July 2024

Lack of sleep has been found to be associated with cognitive impairment in children, yet the neural mechanism underlying this relationship remains poorly understood. To address this issue, this study utilized the data from the Adolescent Brain Cognitive Development (ABCD) study (n = 4930, aged 9–10), involving their sleep assessments, cognitive measures, and functional magnetic resonance imaging (fMRI) during an emotional n-back task. Using partial correlations analysis, we found that the out-of-scanner cognitive performance was positively correlated with sleep duration. Additionally, the activation of regions of interest (ROIs) in frontal and parietal cortices for the 2-back versus 0-back contrast was positively correlated with both sleep duration and cognitive performance. Mediation analysis revealed that this activation significantly mediated the relationship between sleep duration and cognitive function at both individual ROI level and network level. After performing analyses separately for different sexes, it was revealed that the mediation effect of the task-related activation was present in girls (n = 2546). These findings suggest that short sleep duration may lead to deficit in cognitive function of children, particularly in girls, through the modulation of frontoparietal activation during working memory load.
The Advantages of Combining Therapies in Treating Psychiatric Patients
Authors: Rajkumar Ravi Philip
Published: July 2024

Mental illnesses are among the leading causes of morbidity and disability worldwide, and the burden associated with these disorders has increased steadily over the past three decades [...]
The Effects of Illegitimate Tasks on Task Crafting and Cyberloafing: The Role of Stress Mindset and Stress Appraisal
Authors: Ma Qian , Xie Yuxuan
Published: July 2024

Previous studies have mainly focused on the detrimental effects of illegitimate tasks as ubiquitous workplace stressors while ignoring the appraisal measures for such tasks. The term “illegitimate” is used by employees to describe the alignment of a task with their job role rather than the inherent qualities of the task itself. Thus, drawing on the transactional theory of stress, this study examines the moderating effect of the stress mindset on the relationship between illegitimate tasks and the appraisal of such tasks. On this basis, this study further explores when cognitive appraisal mediates the effects of illegitimate tasks on coping behaviors (task crafting and cyberloafing). Data were collected from 285 employees from an energy company in Shandong, China, by using a time-lagged research design. The findings indicate that employees react differently to illegitimate tasks depending on their stress mindset. Specifically, for employees with a stress-is-enhancing mindset, illegitimate tasks induce their challenge appraisal, which leads to task crafting. In addition, illegitimate tasks induce hindrance appraisal in employees with a stress-is-debilitating mindset, which leads to cyberloafing. In practice, this research study suggests that when illegitimate tasks cannot be eliminated, organizations should consider employees’ stress mindset when assigning such tasks.
Carbon Reduction Potential of Flexible Energy Use for Air Conditioning Considering Uncertainty: A Case Study
Authors: Jin Lu , Sun Min , Dou Zhenlan , Huang Zishuo , Chen Yinhui
Published: July 2024

Flexible air conditioning energy use, leveraging building thermal inertia and thermal energy storage, can effectively reduce building carbon emissions. The carbon reduction potential of flexible energy use in air conditioning is influenced by uncertainties, such as dynamic electricity carbon emission factors. To accurately quantify this potential, a methodology for calculating the carbon reduction achievable through flexible energy use in air conditioning, considering these uncertainties, is proposed. First, the sources of uncertainty in air conditioning energy use are identified and mathematically described. Next, the relationship between uncertainty, load, and carbon emissions is analyzed. Subsequently, the carbon reduction mechanisms of various flexible air conditioning energy use methods, based on building thermal inertia and energy storage, are, respectively, explained, and corresponding mathematical models are established. Finally, a case study is conducted to verify the feasibility of the method and reveal the characteristics of the carbon reduction potential of various flexible energy use methods, considering uncertainty.
Unveiling the Structure of Metal–Nanodiamonds Bonds: Experiment and Theory
Authors: Boukhvalov Danil W. , Osipov Vladimir Yu. , Serikkanov Abay , Takai Kazuyuki
Published: July 2024

In this study, we conducted a theoretical simulation to compare the effects of various factors on the atomic and electronic structures and the magnetic properties of copper and gadolinium ions bonded to carboxylated species of (111) diamond surfaces. It was experimentally found that in the temperature range above 120 K, the magnetic moments of chelated Gd3+ and Cu2+ equal 6.73 and 0.981 Bohr magnetons, respectively. In the temperature range from 12 to 2 K, these magnetic moments sharply decrease to 6.38 and 0.88 Bohr magnetons. Specifically, we examined the effects of the number of covalent adatom–diamond substrate bridges, coordination of water molecules, and shallow carbon-inherited spins in the substrate on the physical properties of the metal center. Our simulation predicted that increasing the number of bonds between the chelated metal ion and substrate while decreasing the number of coordinating water molecules corresponded to a decrease in the magnetic moment of metal ions in a metal–diamond system. This is due to the redistribution of the electron charge density in an asymmetric metal–diamond system. By comparing our theoretical results with experimental data, we proposed configurations involving one and, in a minor number of cases, two surface –COO− groups and maximum coordination of water molecules as the most realistic options for Cu- and Gd-complexes.
Anticancer Effect of PtIIPHENSS, PtII5MESS, PtII56MESS and Their Platinum(IV)-Dihydroxy Derivatives against Triple-Negative Breast Cancer and Cisplatin-Resistant Colorectal Cancer
Authors: Elias Maria George , Fatima Shadma , Mann Timothy J. , Karan Shawan , Mikhael Meena , de Souza Paul , Gordon Christopher P. , Scott Kieran F. , Aldrich-Wright Janice R.
Published: July 2024

Development of resistance to cisplatin, oxaliplatin and carboplatin remains a challenge for their use as chemotherapies, particularly in breast and colorectal cancer. Here, we compare the anticancer effect of novel complexes [Pt(1,10-phenanthroline)(1S,2S-diaminocyclohexane)](NO3)2 (PtIIPHENSS), [Pt(5-methyl-1,10-phenanthroline)(1S,2S-diaminocyclohexane)](NO3)2 (PtII5MESS) and [Pt(5,6-dimethyl-1,10-phenanthroline)(1S,2S-diaminocyclohexane)](NO3)2 (PtII56MESS) and their platinum(IV)-dihydroxy derivatives with cisplatin. Complexes are greater than 11-fold more potent than cisplatin in both 2D and 3D cell line cultures with increased selectivity for cancer cells over genetically stable cells. ICP-MS studies showed cellular uptake occurred through an active transport mechanism with considerably altered platinum concentrations found in the cytoskeleton across all complexes after 24 h. Significant reactive oxygen species generation was observed, with reduced mitochondrial membrane potential at 72 h of treatment. Late apoptosis/necrosis was shown by Annexin V-FITC/PI flow cytometry assay, accompanied by increased sub-G0/G1 cells compared with untreated cells. An increase in S and G2+M cells was seen with all complexes. Treatment resulted in significant changes in actin and tubulin staining. Intrinsic and extrinsic apoptosis markers, MAPK/ERK and PI3K/AKT activation markers, together with autophagy markers showed significant activation of these pathways by Western blot. The proteomic profile investigated post-72 h of treatment identified 1597 MDA−MB−231 and 1859 HT29 proteins quantified by mass spectroscopy, with several differentially expressed proteins relative to no treatment. GO enrichment analysis revealed a statistically significant enrichment of RNA/DNA-associated proteins in both the cell lines and specific additional processes for individual drugs. This study shows that these novel agents function as multi-mechanistic chemotherapeutics, offering promising anticancer potential, and thereby supporting further research into their application as cancer therapeutics.
Antibody-Drug Conjugates: The New Treatment Approaches for Ovarian Cancer
Authors: Sato Sho , Shoji Tadahiro , Jo Ami , Otsuka Haruka , Abe Marina , Tatsuki Shunsuke , Chiba Yohei , Takatori Eriko , Kaido Yoshitaka , Nagasawa Takayuki , Kagabu Masahiro , Baba Tsukasa
Published: July 2024

Ovarian cancer (OC), accounting for approximately 200,000 deaths worldwide annually, is a heterogeneous disease showing major differences in terms of its incidence, tumor behavior, and outcomes across histological subtypes. In OC, primary chemotherapy, paclitaxel carboplatin, bevacizumab, and PARP inhibitors have shown prolonged progression-free survival and a favorable overall response rate compared to conventional treatments. However, treatment options for platinum-resistant recurrence cases are limited, with no effective therapies that significantly prolong the prognosis. Recently, mirvetuximab soravtansine, an alpha-folate receptor (FRα)-targeted antibody-drug conjugate (ADC), was approved by the US Food and Drug Administration for patients with FRα-positive recurrent epithelial OC (EOC). This approval was based on a Phase II study, which demonstrated its efficacy in such patients. ADCs comprise an antibody, a linker, and a payload, representing new concept agents without precedence. Advanced clinical studies are developing ADCs for patients with OC, targeting solid tumors such as gynecologic cancer. Ongoing clinical trials are evaluating ADCs targeting FRα and human epidermal growth factor receptor 2, trophoblast cell surface antigen-2, sodium-dependent phosphate transport protein 2B, and cadherin-6 in Phase II/III studies. In this review, we summarize the existing evidence supporting the use of ADCs in OC, discuss ongoing clinical trials and preclinical studies, and explore the potential of these innovative agents to address the challenges in OC treatment.
Decoding the Prognostic Significance and Therapeutic Implications of Inflammation-Based Scores in Hepatocellular Carcinoma: A Comprehensive Review
Authors: Kotsifa Evgenia , Machairas Nikolaos , Angelis Apostolos , Nikiteas Nikolaos I. , Dimitroulis Dimitrios , Sotiropoulos Georgios C.
Published: July 2024

Hepatocellular carcinoma (HCC) is the most common primary liver cancer, posing a significant global health challenge with an increasing incidence. In recent years, multiple staging systems and scores have been proposed, emphasising the necessity for the development of precise prognostic tools. The well-documented etiological relationship between chronic inflammation and carcinogenesis has prompted researchers to explore novel prognostic markers associated with the inflammatory status of HCC patients. This review summarises the current data about inflammation-based scores in the context of HCC. We discuss established scores like the Glasgow Prognostic Score (GPS), modified GPS (mGPS) and the neutrophil-to-lymphocyte ratio (NLR) and others not as extensively studied, examining their utility in predicting survival outcomes and treatment response in HCC patients. Furthermore, we explore emerging scores, including the prognostic nutritional index (PNI) and other lymphocyte-based scores, assessing their potential in refining risk stratification and guiding therapeutic decisions in the era of precision medicine. As research progresses and these scores undergo further refinement and integration into the evolving landscape of HCC management, they carry significant potential for improving patient outcomes.
Effects of Combined Interventions of Physical Activity and Diet in Childhood Cancer Survivors: A Systematic Review
Authors: Vasconcelos Carlos , Sousa Patrícia
Published: July 2024

Physical activity and diet have complementary benefits for attenuating adverse health effects that childhood cancer survivors experience after the end of treatment. This review aimed to explore the impact of combined physical activity and diet interventions on the health status of childhood cancer survivors. A thorough review of the literature was carried out using the Cochrane Library, PubMed, Scielo, LILACS and Web of Science databases for studies published until June 2024. Studies concerning survivors of childhood cancer of any type engaged exclusively in combined diet/physical activity interventions were included in this review. Three manuscripts met the inclusion criteria. The results indicated that combined physical activity plus diet interventions showed beneficial impacts for the intestinal microbiome, percentage of calories from sweet foods, daily consumption of sugary beverages, reduction in sedentary activity, and mood (1 out of 1 study for each of the presented outcomes). Although more rigorous studies are needed, these findings showed promising results regarding the impact of interventions involving both physical activity and diet on childhood cancer survivors
Effect of SiO2 Layer Thickness on SiO2/Si3N4 Multilayered Thin Films
Authors: Huang Ziming , Duan Jiaqi , Li Minghan , Ma Yanping , Jiang Hong
Published: July 2024

Silicon nitride (Si3N4) materials are widely used in the electronics, optoelectronics, and semiconductor industries, with Si3N4 thin films exhibiting high densities, high dielectric constants, good insulation performance, and good thermal and chemical stability. However, direct deposition of Si3N4 thin films on glass can result in considerable tensile stress and cracking. In this study, magnetron sputtering was used to deposit a Si3N4 thin film on glass, and a silicon dioxide (SiO2) thin film was introduced to reduce the Si3N4 binding force and stress. The effect of the SiO2 layer thickness on the SiO2/Si3N4 multilayered thin film was explored. The results indicated that the introduction of the SiO2 layer could improve the weak adhesion characteristics of Si3N4 thin films. Moreover, sputtering the SiO2 layer to 150 nm resulted in the highest hardness and transmittance of the SiO2/Si3N4 multilayered thin films. The findings of this study lay a solid foundation for the application of Si3N4 thin films on glass.
Methods of Distributing the IF-WS2 Modifier for Its Introduction into the Structure of the Al2O3 Aluminum Oxide Coating
Authors: Korzekwa Joanna , Niedźwiedź Mateusz , Dercz Grzegorz , Cwynar Krzysztof , Sowa Maciej , Bara Marek , Simka Wojciech
Published: July 2024

The microstructures and structures of modified Al2O3/IF-WS2 coatings prepared on aluminum substrates are studied. Amorphous Al2O3 oxide coatings are obtained on EN AW 5251 aluminum alloy using the electrooxidation process. The quality of the IF-WS2 nanopowder is of great importance in the process of its introduction into the nanopores of the Al2O3 oxide coating. Commercial nanopowder tends to agglomerate, and without appropriate pretreatment, it is difficult to introduce it into the nanopores of the coating. To improve the degree of fragmentation of the IF-WS2 nanopowder, an experiment was carried out to distribute the nanopowder in the presence of strong ultrasounds, and new conditions for introducing the powder into the nanopores were used. A two-level design of experiment (DOE) was used. The SEM examination made it possible to conclude that Method A contributed to a more even distribution of nanoparticles in the microstructure of Al2O3 coatings. GIXD analyses showed the presence of WO3 derived from the IF-WS2 modifier next to crystal structures derived from aluminum and WS2. Modification of coatings using Method A resulted in surfaces with lower contact angles measured with polar liquids and higher surface free energy compared to Method B.
Natural Convection Fluid Flow and Heat Transfer in a Valley-Shaped Cavity
Authors: Bhowmick Sidhartha , Roy Laxmi Rani , Xu Feng , Saha Suvash C.
Published: July 2024

The phenomenon of natural convection is the subject of significant research interest due to its widespread occurrence in both natural and industrial contexts. This study focuses on investigating natural convection phenomena within triangular enclosures, specifically emphasizing a valley-shaped configuration. Our research comprehensively analyses unsteady, non-dimensional time-varying convection resulting from natural fluid flow within a valley-shaped cavity, where the inclined walls serve as hot surfaces and the top wall functions as a cold surface. We explore unsteady natural convection flows in this cavity, utilizing air as the operating fluid, considering a range of Rayleigh numbers from Ra = 100 to 108. Additionally, various non-dimensional times τ, spanning from 0 to 5000, are examined, with a fixed Prandtl number (Pr = 0.71) and aspect ratio (A = 0.5). Employing a two-dimensional framework for numerical analysis, our study focuses on identifying unstable flow mechanisms characterized by different non-dimensional times, including symmetric, asymmetric, and unsteady flow patterns. The numerical results reveal that natural convection flows remain steady in the symmetric state for Rayleigh values ranging from 100 to 7 × 103. Asymmetric flow occurs when the Ra surpasses 7 × 103. Under the asymmetric condition, flow arrives in an unsteady stage before stabilizing at the fully formed stage for 7 × 103 < Ra < 107. This study demonstrates that periodic unsteady flows shift into chaotic situations during the transitional stage before transferring to periodic behavior in the developed stage, but the chaotic flow remains predominant in the unsteady regime with larger Rayleigh numbers. Furthermore, we present an analysis of heat transfer within the cavity, discussing and quantifying its dependence on the Rayleigh number.
Modeling the Properties of Magnetostrictive Elements Using Quantum Emulators
Authors: Karpukhin Edvard , Bormotov Alexey , Manukyan Luiza
Published: July 2024

The article discusses mathematical and numerical methods for modeling magnetostrictive multielectronic systems based on a combination of quantum and classical methods. The algorithm development suitable for the investigation of magnetostrictive phenomena at the micro level using the classical-quantum method implemented on a modern classical computer is justified. The algorithms and structure of the software package are given. The adequacy of the quantum-classical method is verified by comparing the calculated results of the properties of known magnetostrictive materials with the real properties of magnetostrictive alloys.
The Biological Crystals in Chamid Bivalve Shells: Diversity in Morphology and Crystal Arrangement Pattern
Authors: Hoerl Sebastian , Griesshaber Erika , Checa Antonio G. , Schmahl Wolfgang W.
Published: July 2024

Chamid bivalves are marine organisms that live in high-energy environments and are cemented to hard substrates. To avoid shell damage, the organisms form thick, densely ornamented shells. Shell material consists of aragonite, and the ornamentation may be either aragonitic or calcitic. The latter can be developed as scaly spines, rows of blades, or comarginal, radial arched lamellae. We investigated biological crystal morphology and mode of assembly of Chama arcana and Chama gryphoides shells. Structural characteristics were obtained from electron backscatter diffraction (EBSD) measurements, complemented with laser confocal and BSE imaging. We found a wide range of crystal morphologies and sizes, ranging from irregularly shaped calcite and/or aragonite prisms to tiny and thin aragonite laths. We observed four different modes of crystal assembly patterns: 1. strongly interlocked dendritic calcite units forming the ornamentation blades; 2. aragonite laths arranged to lamellae forming the outer shell layer, the layer adjacent to the calcite; 3. aragonite laths arranged into blocks comprising inner shell layers or aragonitic ornamentations; and 4. shell portions consisting of aragonite prisms, structured in size and crystal orientation, at muscle attachment sites. These four different types of crystal arrangements were observed for the shells of the investigated chamid species; however, they had slightly different strengths of structuring and slight variations in crystal organisation. Additionally, we observed unique microstructural features in Chama shells: We report ornamentation crystals resembling idiomorphic calcite and novel, twinned entities found at the changeover between the aragonitic layers. We highlight and discuss these differences and anomalies in this contribution.
Temporal Variation in and Influence of Environmental Variables on a Lepidopteran Community in a Mediterranean Mid-Mountain Area
Authors: Bernabé-Ruiz Pedro M. , Jiménez-Nieva Francisco J. , Pérez-Quintero Juan C.
Published: July 2024

The temporal variation in a community of nocturnal and diurnal Lepidoptera was studied in a Mediterranean mid-mountain area of the SW Iberian Peninsula between 2017 and 2019. Monthly samplings that allowed for the identification of 3528 specimens, belonging to 373 species from 40 different families, also provided data on the temporal and seasonal variation in richness and the abundance (dominated by Geometridae and Noctuidae), diet type (mainly oligophagous), voltinism (mostly univoltine) and biogeography of the community, primarily Mediterranean in scope. Richness, abundance and diversity were also found to be highly positively correlated with temperature and solar radiation, and less negatively correlated with precipitation and humidity. Canonical correspondence analyses (CCAs) also indicate that temperature and radiation are the climatic variables with the greatest influence on species occurrence over the different months of the year. The CCAs gave a cumulative variance value of 84.79% when using the monthly mean values of temperature, solar radiation and minimum relative humidity, and 86.4% if only monovoltine species were considered. Guidelines to maintain diversity in the environment of the study area are provided. It is possible that the area may function as a refuge area for Lepidoptera in the face of climate change and deforestation that are occurring in the geographical environment.
COVID-19 and Prostatitis: A Review of Current Evidence
Authors: Daneshwar Datesh , Lee Yemin , Nordin Abid
Published: July 2024

Coronavirus disease 2019 (COVID-19), a highly contagious viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a global health threat. The virus enters host cells by binding with angiotensin-converting enzyme 2 (ACE2), which is then facilitated by the protease activity of transmembrane serine protease 2 (TMPRSS2). It triggers a cytokine storm that eventually leads to cell apoptosis, tissue damage, and organ failure. Therefore, any organs in the human body that have both receptors are highly susceptible to COVID-19 infection, potentially resulting in multiple-organ failure. The prostate has been reported to express high levels of ACE2 and TMPRSS2. While there are limited studies regarding the association between COVID-19 and prostatitis, the possibility that SARS-CoV-2 could cause prostatitis cannot be denied. Thus, through this review, a better insight into the associations of SAR-CoV-2 can be provided.
Analyzing Sequential Betting with a Kelly-Inspired Convective-Diffusion Equation
Authors: Velegol Darrell , Bishop Kyle J. M.
Published: July 2024

The purpose of this article is to analyze a sequence of independent bets by modeling it with a convective-diffusion equation (CDE). The approach follows the derivation of the Kelly Criterion (i.e., with a binomial distribution for the numbers of wins and losses in a sequence of bets) and reframes it as a CDE in the limit of many bets. The use of the CDE clarifies the role of steady growth (characterized by a velocity U) and random fluctuations (characterized by a diffusion coefficient D) to predict a probability distribution for the remaining bankroll as a function of time. Whereas the Kelly Criterion selects the investment fraction that maximizes the median bankroll (0.50 quantile), we show that the CDE formulation can readily find an optimum betting fraction f for any quantile. We also consider the effects of “ruin” using an absorbing boundary condition, which describes the termination of the betting sequence when the bankroll becomes too small. We show that the probability of ruin can be expressed by a dimensionless Péclet number characterizing the relative rates of convection and diffusion. Finally, the fractional Kelly heuristic is analyzed to show how it impacts returns and ruin. The reframing of the Kelly approach with the CDE opens new possibilities to use known results from the chemico-physical literature to address sequential betting problems.
Model-Based Thermal Stress and Lifetime Estimation of DFIG Wind Power Converter
Authors: Yu Xinming , Iannuzzo Francesco , Zhou Dao
Published: July 2024

Turbine systems equipped with doubly fed induction generation (DFIG) are becoming increasingly vital in wind power generation, with the reliability of the devices serving as a pillar in the industrial sector. Thermal stress and lifetime assessment are fundamental indicators in this regard. This paper primarily addresses the thermal stress and lifespan of power semiconductor devices utilized in a DFIG grid-side converter (GSC) and rotor-side converter (RSC). PLECS (Piecewise Linear Electrical Circuit Simulation) is employed to validate the electrical and thermal stress of the power devices. Additionally, Ansys Icepak, a finite element analysis (FEA) software, is utilized to confirm temperature fluctuations under various operations. The power consumption and junction temperature of the power devices in the GSC and RSC of a 2 MW DFIG are compared. It is evident that the most stressed power semiconductor is the IGBT for the GSC with a temperature swing of 3.4 °C, while the diode in the RSC is the most stressed with a temperature swing of 10.1 °C. This paper also presents a lifetime model to estimate the lifespan of the power device based on the annual wind profile. By considering the annual mission profile, we observe that the lifetime of the back-to-back power converter is limited by the diode of the RSC, whose B10 lifetime is calculated at 15 years.
Research on the Protection System for Smart Grid Based on Phasor Information at Circuit Breakers
Authors: Liu Yi , Dang Ding , Lee Seon-Keun
Published: July 2024

A smart grid protection system based on phasor information at circuit breakers is proposed in this paper. Phasor data for fault diagnosis is obtained from phasor measurement units or intelligent electronic devices installed near circuit breakers, without the need for additional measurement equipment. When a fault occurs, the protection system first locates the core protection circuit breaker closest to the fault point. It then identifies the faulty component by analyzing the current phasor differences between this breaker and adjacent ones. This scheme offers high computational efficiency, enabling rapid identification of faulty equipment and its precise location. The proposed protection system structure can be divided into two types: centralized and decentralized, and the most suitable scheme should be selected based on the actual situation. Finally, the feasibility of the proposed scheme was verified through the IEEE 39-bus system and a simulated actual area power grid model, demonstrating its applicability to practical smart grid scenarios. The simulation network validates the implementation method of the proposed protection strategy.
Optimal Electric Motor Designs of Light Electric Vehicles: A Review
Authors: Gmyrek Zbigniew
Published: July 2024

This paper summarizes the results of numerous studies aimed at improving the operating characteristics of electric motors used in light electric vehicles (LEVs). This review focuses on four types of electric motors that can be installed in the drive wheel rims of LEVs. Due to the availability of new magnetic materials and the use of advanced techniques for optimizing the design of electric motors, new motor topologies have emerged. The latest generation motors have been shown to be more efficient, have higher torque density, and generate less torque ripple. This paper indicates and discusses current trends in the topology of electric motors designed for LEV drives. In this context, the effectiveness of the proposed design modifications in terms of selected motor operational characteristics was assessed. The proposed new topologies were compared with commercial solutions, also in terms of the possibility of improving their operational parameters.
Forest Fire Prediction Based on Time Series Networks and Remote Sensing Images
Authors: Cao Yue , Zhou Xuanyu , Yu Yanqi , Rao Shuyu , Wu Yihui , Li Chunpeng , Zhu Zhengli
Published: July 2024

Protecting forest resources and preventing forest fires are vital for social development and public well-being. However, current research studies on forest fire warning systems often focus on extensive geographic areas like states, counties, and provinces. This approach lacks the precision and detail needed for predicting fires in smaller regions. To address this gap, we propose a Transformer-based time series forecasting model aimed at improving the accuracy of forest fire predictions in smaller areas. Our study focuses on Quanzhou County, Guilin City, Guangxi Province, China. We utilized time series data from 2021 to 2022, along with remote sensing images and ArcGIS technology, to identify various factors influencing forest fires in this region. We established a time series dataset containing twelve influencing factors, each labeled with forest fire occurrences. By integrating these data with the Transformer model, we generated forest fire danger level prediction maps for Quanzhou County. Our model’s performance is compared with other deep learning methods using metrics such as RMSE, and the results reveal that the proposed Transformer model achieves higher accuracy (ACC = 0.903, MAPE = 0.259, MAE = 0.053, RMSE = 0.389). This study demonstrates that the Transformer model effectively takes advantage of spatial background information and the periodicity of forest fire factors, significantly enhancing predictive accuracy.