bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplemental Legends from FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling
Authors: Yang Xuguang , Lin Yuli , Shi Yinghong , Li Bingji , Liu Weiren , Yin Wei , Dang Yongjun , Chu Yiwei , Fan Jia , He Rui
Published: April 2023

Supplemental Legends
Supplementary material and methods from Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer
Authors: Lazar Ikrame , Clement Emily , Dauvillier Stéphanie , Milhas Delphine , Ducoux-Petit Manuelle , LeGonidec Sophie , Moro Cédric , Soldan Vanessa , Dalle Stéphane , Balor Stéphanie , Golzio Muriel , Burlet-Schiltz Odile , Valet Philippe , Muller Catherine , Nieto Laurence
Published: April 2023

Supplementary material and methods
supplemental figure legends from Acetylcarnitine Is a Candidate Diagnostic and Prognostic Biomarker of Hepatocellular Carcinoma
Authors: Lu Yonghai , Li Ning , Gao Liang , Xu Yong-Jiang , Huang Chong , Yu Kangkang , Ling Qingxia , Cheng Qi , Chen Shengsen , Zhu Mengqi , Fang Jinling , Chen Mingquan , Ong Choon Nam
Published: April 2023

Figure legends of supplemental figures 1-5.
Supplementary Methods and Reference from An Epigenetic Reprogramming Strategy to Resensitize Radioresistant Prostate Cancer Cells
Authors: Peitzsch Claudia , Cojoc Monica , Hein Linda , Kurth Ina , Mäbert Katrin , Trautmann Franziska , Klink Barbara , Schröck Evelin , Wirth Manfred P. , Krause Mechthild , Stakhovsky Eduard A. , Telegeev Gennady D. , Novotny Vladimir , Toma Marieta , Muders Michael , Baretton Gustavo B. , Frame Fiona M. , Maitland Norman J. , Baumann Michael , Dubrovska Anna
Published: April 2023

Description of additional methods and procedures used in the study. Also includes Supplementary Reference.
Supplementary Figure 4 from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors
Authors: Kim So-Youn , Ebbert Katherine , Cordeiro Marilia H. , Romero Megan M. , Whelan Kelly A. , Suarez Adrian A. , Woodruff Teresa K. , Kurita Takeshi
Published: April 2023

Gross morphology (A) and histology (B) of GCT grafts.
Nwani et al., Supplementary methods and tables from Melanoma Cells Block PEDF Production in Fibroblasts to Induce the Tumor-Promoting Phenotype of Cancer-Associated Fibroblasts
Authors: Nwani Nkechiyere G. , Deguiz Maria L. , Jimenez Benilde , Vinokour Elena , Dubrovskyi Oleksii , Ugolkov Andrey , Mazar Andrew P. , Volpert Olga V.
Published: April 2023

Table 1. Biochemical inhibitors used in the study Table 2. Primary antibodies used for Western blot Table 3. Secondary antibodies used for Western blot Table 4. Spontaneous metastasis in PEDF-nul and control mice
Suppl Fig-Tab from GALNT1-Mediated Glycosylation and Activation of Sonic Hedgehog Signaling Maintains the Self-Renewal and Tumor-Initiating Capacity of Bladder Cancer Stem Cells
Authors: Li Chong , Du Ying , Yang Zhao , He Luyun , Wang Yanying , Hao Lu , Ding Mingxia , Yan Ruping , Wang Jiansong , Fan Zusen
Published: April 2023

Supplementary Figures 1-3 and Supplementary Table 1. Supplementary Figure 1. GALNT1-mediated SHH processing is related to Gli1 expression in BCSCs. Supplementary Figure 2. O-linked glycosylation sites of SHH were predicted by NetOGlyc 3.1 Server tool. Supplementary Figure 3. SHH and its mutants were detected by ELLA. Supplementary Table 1. Primer oligonucleotides for qPCR
Supplementary Figure Legends from Chromogranin A Is Preferentially Cleaved into Proangiogenic Peptides in the Bone Marrow of Multiple Myeloma Patients
Authors: Bianco Mimma , Gasparri Anna Maria , Colombo Barbara , Curnis Flavio , Girlanda Stefania , Ponzoni Maurilio , Bertilaccio Maria Teresa Sabrina , Calcinotto Arianna , Sacchi Angelina , Ferrero Elisabetta , Ferrarini Marina , Chesi Marta , Bergsagel P. Leif , Bellone Matteo , Tonon Giovanni , Ciceri Fabio , Marcatti Magda , Caligaris-Cappio Federico , Corti Angelo
Published: April 2023

Legend for Supplementary Figures S1-S5.
SUPPLEMENTARY FIGURE 1. Primary CD138+-myeloma cells in bone marrow aspirates express αvβ3/αvβ5 integrins and IGF1R. from Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth
Authors: Beauvais DeannaLee M. , Jung Oisun , Yang Yang , Sanderson Ralph D. , Rapraeger Alan C.
Published: April 2023

Bone marrow aspirates from 12 individual patients were incubated on Sdc1 antibody to capture CD138+ myeloma cells and exclude other cell types present in the aspirates. Captured cells were fixed and stained for αvβ3 (LM609), αvβ5 (P1F6), or IGF1R (JBW902). Stained cells were counted and expressed as a percentage of total captured cells. Data points represent the mean of a minimum of four replicates for each patient.
Supplementary figures S1-S6 from Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade
Authors: Eichten Alexandra , Su Jia , Adler Alexander P. , Zhang Li , Ioffe Ella , Parveen Asma A. , Yancopoulos George D. , Rudge John , Lowy Israel , Lin Hsin Chieh , MacDonald Douglas , Daly Christopher , Duan Xunbao , Thurston Gavin
Published: April 2023

Supplementary figures S1-S6
Table S2 from Mathematical Modeling Reveals That Changes to Local Cell Density Dynamically Modulate Baseline Variations in Cell Growth and Drug Response
Authors: Greene James M. , Levy Doron , Herrada Sylvia P. , Gottesman Michael M. , Lavi Orit
Published: April 2023

Growth curves of different combinations of local and global cell density conditions for 10 days
Supplemental Figure legends from miR-17-92/p38α Dysregulation Enhances Wnt Signaling and Selects Lgr6+ Cancer Stem-like Cells during Lung Adenocarcinoma Progression
Authors: Guinot Anna , Oeztuerk-Winder Feride , Ventura Juan-Jose
Published: April 2023

Detailed descriptions of the supplemental figures
Supplementary Table from HSPB1 Inhibits the Endothelial-to-Mesenchymal Transition to Suppress Pulmonary Fibrosis and Lung Tumorigenesis
Authors: Choi Seo-Hyun , Nam Jae-Kyung , Kim Bu-Yeo , Jang Junho , Jin Young-Bae , Lee Hae-June , Park Seungwoo , Ji Young Hoon , Cho Jaeho , Lee Yoon-Jin
Published: April 2023

Supplementary Table S1. Primers information for Reverse transcription (RT)-PCR
Supplementary Materials and Methods from HSPB1 Inhibits the Endothelial-to-Mesenchymal Transition to Suppress Pulmonary Fibrosis and Lung Tumorigenesis
Authors: Choi Seo-Hyun , Nam Jae-Kyung , Kim Bu-Yeo , Jang Junho , Jin Young-Bae , Lee Hae-June , Park Seungwoo , Ji Young Hoon , Cho Jaeho , Lee Yoon-Jin
Published: April 2023

Supplementary Materials and Methods
Supplementary Figure 3 from Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells
Authors: Lucenay Kimberly S. , Doostan Iman , Karakas Cansu , Bui Tuyen , Ding Zhiyong , Mills Gordon B. , Hunt Kelly K. , Keyomarsi Khandan
Published: April 2023

ACLY downregulation in LMW-E TDCs does not affect expression of EMT related genes
Supplementary Figure S5 from Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198
Authors: Molenaar Remco J. , Botman Dennis , Smits Myrthe A. , Hira Vashendriya V. , van Lith Sanne A. , Stap Jan , Henneman Peter , Khurshed Mohammed , Lenting Krissie , Mul Adri N. , Dimitrakopoulou Dionysia , van Drunen Cornelis M. , Hoebe Ron A. , Radivoyevitch Tomas , Wilmink Johanna W. , Maciejewski Jaroslaw P. , Vandertop W. Peter , Leenders William P. , Bleeker Fonnet E. , van Noorden Cornelis J.
Published: April 2023

IDH1WT/R132H cells are sensitized to metformin, compared with IDH1WT/WT cells.
Supplementary Figure S4 from Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198
Authors: Molenaar Remco J. , Botman Dennis , Smits Myrthe A. , Hira Vashendriya V. , van Lith Sanne A. , Stap Jan , Henneman Peter , Khurshed Mohammed , Lenting Krissie , Mul Adri N. , Dimitrakopoulou Dionysia , van Drunen Cornelis M. , Hoebe Ron A. , Radivoyevitch Tomas , Wilmink Johanna W. , Maciejewski Jaroslaw P. , Vandertop W. Peter , Leenders William P. , Bleeker Fonnet E. , van Noorden Cornelis J.
Published: April 2023

IDH1MT increase ROS levels and AGI-5198 attenuates this effect.
Supplemental Methods from Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells
Authors: Lucenay Kimberly S. , Doostan Iman , Karakas Cansu , Bui Tuyen , Ding Zhiyong , Mills Gordon B. , Hunt Kelly K. , Keyomarsi Khandan
Published: April 2023

The file includes description of methods pertaining to supplemental figures and details on previously published supplemental methods
Supplementary Figure S3 from Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198
Authors: Molenaar Remco J. , Botman Dennis , Smits Myrthe A. , Hira Vashendriya V. , van Lith Sanne A. , Stap Jan , Henneman Peter , Khurshed Mohammed , Lenting Krissie , Mul Adri N. , Dimitrakopoulou Dionysia , van Drunen Cornelis M. , Hoebe Ron A. , Radivoyevitch Tomas , Wilmink Johanna W. , Maciejewski Jaroslaw P. , Vandertop W. Peter , Leenders William P. , Bleeker Fonnet E. , van Noorden Cornelis J.
Published: April 2023

The IDH1-mutant inhibitor AGI-5198 increases IDH-mediated NAPDH production capacity in IDH1-mutated cells.
Supplementary Materials and Methods from Phenotypic and Signaling Consequences of a Novel Aberrantly Spliced Transcript FGF Receptor-3 in Hepatocellular Carcinoma
Authors: Li Ke , Shen Baiyong , Cheng Xi , Ma Ding , Jing Xiaoqian , Liu Xinyu , Yang Weiping , Peng Chenghong , Qiu Weihua
Published: April 2023

Supplementary Materials and Methods includingï¼š1.Patients, Tissue Specimens, and Cell Culture;2.Nested RT-PCR and Quantitative Real-time PCR;3.Construction of Recombinant Plasmids of FGFR3IIIc, FGFR3Î"7-9, and FGFR3AT-I and Transient Transfection of Cell Lines;4.Lentivirus Packaging, Virus Transduction, Fluorescent Cell Selection, and Proliferation Evaluation and so on...
Supplementary Figure 4 from RK-33 Radiosensitizes Prostate Cancer Cells by Blocking the RNA Helicase DDX3
Authors: Xie Min , Vesuna Farhad , Tantravedi Saritha , Bol Guus M. , Heerma van Voss Marise R. , Nugent Katriana , Malek Reem , Gabrielson Kathleen , van Diest Paul J. , Tran Phuoc T. , Raman Venu
Published: April 2023

Boyden chamber assay
Supplementary Table S1 from Deep Sequencing Reveals a Novel miR-22 Regulatory Network with Therapeutic Potential in Rhabdomyosarcoma
Authors: Bersani Francesca , Lingua Marcello Francesco , Morena Deborah , Foglizzo Valentina , Miretti Silvia , Lanzetti Letizia , Carrà Giovanna , Morotti Alessandro , Ala Ugo , Provero Paolo , Chiarle Roberto , Singer Samuel , Ladanyi Marc , Tuschl Thomas , Ponzetto Carola , Taulli Riccardo
Published: April 2023

miRNAs abundance in RMS and muscle.
SUPPLEMENTARY figure 1 from IGFBP2 Activates the NF-κB Pathway to Drive Epithelial–Mesenchymal Transition and Invasive Character in Pancreatic Ductal Adenocarcinoma
Authors: Gao Song , Sun Yan , Zhang Xuebin , Hu Limei , Liu Yuexin , Chua Corrine Yingxuan , Phillips Lynette M. , Ren He , Fleming Jason B. , Wang Huamin , Chiao Paul J. , Hao Jihui , Zhang Wei
Published: April 2023

Expression of IGFBP2 in cell lines, tumors from orthotopic mouse models, and clinical samples.
Supplementary Figure S3 from Deep Sequencing Reveals a Novel miR-22 Regulatory Network with Therapeutic Potential in Rhabdomyosarcoma
Authors: Bersani Francesca , Lingua Marcello Francesco , Morena Deborah , Foglizzo Valentina , Miretti Silvia , Lanzetti Letizia , Carrà Giovanna , Morotti Alessandro , Ala Ugo , Provero Paolo , Chiarle Roberto , Singer Samuel , Ladanyi Marc , Tuschl Thomas , Ponzetto Carola , Taulli Riccardo
Published: April 2023

miR-22 does not induce RMS cell terminal differentiation.
Supplementary figure 4 from PAK4 Phosphorylates p53 at Serine 215 to Promote Liver Cancer Metastasis
Authors: Xu Hai-Tao , Lai Wai-Lung , Liu Heong-Fai , Wong Leo Lap-Yan , Ng Irene Oi-Lin , Ching Yick Pang
Published: April 2023

Stable PAK4 knockdown (Sh-C2) and vector control (V-C1) HLE clones transiently transfected with the constructs expressing WT, S215A or S215D mutant of p53 were used for Transwell migration assay.
Supplementary Figure S2 from Deep Sequencing Reveals a Novel miR-22 Regulatory Network with Therapeutic Potential in Rhabdomyosarcoma
Authors: Bersani Francesca , Lingua Marcello Francesco , Morena Deborah , Foglizzo Valentina , Miretti Silvia , Lanzetti Letizia , Carrà Giovanna , Morotti Alessandro , Ala Ugo , Provero Paolo , Chiarle Roberto , Singer Samuel , Ladanyi Marc , Tuschl Thomas , Ponzetto Carola , Taulli Riccardo
Published: April 2023

miR-22 and -378 expression and phenotypic analyses.
Supplementary data from PAK4 Phosphorylates p53 at Serine 215 to Promote Liver Cancer Metastasis
Authors: Xu Hai-Tao , Lai Wai-Lung , Liu Heong-Fai , Wong Leo Lap-Yan , Ng Irene Oi-Lin , Ching Yick Pang
Published: April 2023

The method and material description of supplementary data
Supplementary Tables from UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling
Authors: Li Haolong , Xie Ning , Chen Ruiqi , Verreault Mélanie , Fazli Ladan , Gleave Martin E. , Barbier Olivier , Dong Xuesen
Published: April 2023

Supplementary Tables: Tissue microarray, antibody, primer, vector, siRNA, correlation analysis Information
Supplementary Figure Legend from UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling
Authors: Li Haolong , Xie Ning , Chen Ruiqi , Verreault Mélanie , Fazli Ladan , Gleave Martin E. , Barbier Olivier , Dong Xuesen
Published: April 2023

Supplementary Figure Legend
Figure S4 from UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling
Authors: Li Haolong , Xie Ning , Chen Ruiqi , Verreault Mélanie , Fazli Ladan , Gleave Martin E. , Barbier Olivier , Dong Xuesen
Published: April 2023

Figure S4: C-Src, but not AKT or STAT3 signaling is activated by UGT2B17 after prolonged androgen deprivation
Supplementary Table 4 from Integrative Genomic Analysis Identifies the Core Transcriptional Hallmarks of Human Hepatocellular Carcinoma
Authors: Allain Coralie , Angenard Gaëlle , Clément Bruno , Coulouarn Cédric
Published: April 2023

Ingenuity Pathway Analysis (IPA) of up- and down-regulated genes from the core human HCC signature.
Supplementary Tables 1 through 7 and Supplementary Figures 1 through 6 from DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme
Authors: Nagel Zachary D. , Kitange Gaspar J. , Gupta Shiv K. , Joughin Brian A. , Chaim Isaac A. , Mazzucato Patrizia , Lauffenburger Douglas A. , Sarkaria Jann N. , Samson Leona D.
Published: April 2023

Table S1. Relative sensitivity of lymphoblastoid cell lines to alkylating agents; Table S2. DNA repair capacity data for 24 cell lines. Table S3. Correlation coefficients for pairwise linear relationships between DNA repair capacity in multiple pathways in 24 lymphoblastoid cell lines. Table S4. Statistical significance of linear relationships between DNA repair capacity in multiple pathways in 24 lymphoblastoid cell lines. Table S5. Correlation coefficients for pairwise linear relationships between DNA repair capacity and sensitivity to killing with DNA damaging agents in 24 lymphoblastoid cell lines. Table S6. Statistical significance of linear relationships between DNA repair capacity and sensitivity to killing with DNA damaging agents in 24 lymphoblastoid cell lines. Table S7. DNA Repair capacity for indicated repair pathways in PDX models of GBM. Figure S1. Computational Workflow. Figure S2. Diagram of a linear model relating MGMT activity to sensitivity to MNNG. Figure S3. Correlation between MGMT activity (as measured by FM-HCR) and sensitivity to a DNA damaging agent. Figure S4. Scatter plots of observed sensitivity (% Control Growth) versus predicted sensitivity calculated from leave-one-out analysis of the models listed in Table 1. Figure S5. Predicted and observed sensitivity of paired GBM xenograft lines with differential TMZ sensitivities. Figure S6. Correlation between MGMT activity and promoter methylation status.
Supplementary Table 3 from Integrative Genomic Analysis Identifies the Core Transcriptional Hallmarks of Human Hepatocellular Carcinoma
Authors: Allain Coralie , Angenard Gaëlle , Clément Bruno , Coulouarn Cédric
Published: April 2023

Enrichment of up- and down-regulated genes of the core human HCC signature in specific chromosome locations.
Supplemental data from TPL2 Is an Oncogenic Driver in Keratocanthoma and Squamous Cell Carcinoma
Authors: Lee Jun-Han , Lee Joo-Hyung , Lee Sang Hyuk , Do Sung-Im , Cho Sung-Dae , Forslund Ola , Inn Kyung-Soo , Lee Jeong-Sang , Deng Fang-Ming , Melamed Jonathan , Jung Jae U. , Jeong Joseph H.
Published: April 2023

Supplementary Materials and Methods (supplementary information on establsihing cell lines and generating inducible TPL2 transgenic (iTPL2 TG) mice) & Supplementary Figure Legends
Supplementary Data from WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma
Authors: Del Mare Sara , Husanie Hussam , Iancu Ortal , Abu-Odeh Mohammad , Evangelou Konstantinos , Lovat Francesca , Volinia Stefano , Gordon Jonathan , Amir Gail , Stein Janet , Stein Gary S. , Croce Carlo M. , Gorgoulis Vassilis , Lian Jane B. , Aqeilan Rami I.
Published: April 2023

Supplementary Methods, Figures and Tables
Time-lapse videomicroscopy of HT-29 colonic cancer cells from A Squalene-Based Nanomedicine for Oral Treatment of Colon Cancer
Authors: Kotelevets Larissa , Chastre Eric , Caron Joachim , Mougin Julie , Bastian Gerard , Pineau Alain , Walker Francine , Lehy Therese , Desmaële Didier , Couvreur Patrick
Published: April 2023

Video 1 shows untreated HT-29 cells. Images were captured at 1 h intervals for 14h.
Supplemental Figures from TALEN-Mediated Inactivation of PD-1 in Tumor-Reactive Lymphocytes Promotes Intratumoral T-cell Persistence and Rejection of Established Tumors
Authors: Menger Laurie , Sledzinska Anna , Bergerhoff Katharina , Vargas Frederick Arce , Smith Julianne , Poirot Laurent , Pule Martin , Herrero Javier , Peggs Karl S. , Quezada Sergio A.
Published: April 2023

PD-1-TALEN activity screen in murine thymoma EL4 cells.PD-1 gene inactivation in pmel-1 CD8+T cells and functional analysis. PD-1-TALEN activity in TRL from MCA205. Effector/memory phenotype of TRL from MCA205.
Supplementary Figure S5 from PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation
Authors: Zhu Guo , Rankin Sherri L. , Larson Jon D. , Zhu Xiaoyan , Chow Lionel M.L. , Qu Chunxu , Zhang Jinghui , Ellison David W. , Baker Suzanne J.
Published: April 2023

Cells in the proliferative niche of Pten;p53 dKO medulloblastomas express Math1, and give rise to NeuN+ cells in the bulk tumor
Supplementary Figure S4 from PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation
Authors: Zhu Guo , Rankin Sherri L. , Larson Jon D. , Zhu Xiaoyan , Chow Lionel M.L. , Qu Chunxu , Zhang Jinghui , Ellison David W. , Baker Suzanne J.
Published: April 2023

Early perivascular medulloblastoma tumor cells are Pten null
Supplementary Information from IL33 Promotes Colon Cancer Cell Stemness via JNK Activation and Macrophage Recruitment
Authors: Fang Min , Li Yongkui , Huang Kai , Qi Shanshan , Zhang Jian , Zgodzinski Witold , Majewski Marek , Wallner Grzegorz , Gozdz Stanislaw , Macek Pawel , Kowalik Artur , Pasiarski Marcin , Grywalska Ewelina , Vatan Linda , Nagarsheth Nisha , Li Wei , Zhao Lili , Kryczek Ilona , Wang Guobin , Wang Zheng , Zou Weiping , Wang Lin
Published: April 2023

It contains 5 figures and 3 tables
Supplementary Figure S2 from PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation
Authors: Zhu Guo , Rankin Sherri L. , Larson Jon D. , Zhu Xiaoyan , Chow Lionel M.L. , Qu Chunxu , Zhang Jinghui , Ellison David W. , Baker Suzanne J.
Published: April 2023

Characterization of perivascular proliferating cells in Pten cKO cerebellum.
Supplementary Figure S1 from PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation
Authors: Zhu Guo , Rankin Sherri L. , Larson Jon D. , Zhu Xiaoyan , Chow Lionel M.L. , Qu Chunxu , Zhang Jinghui , Ellison David W. , Baker Suzanne J.
Published: April 2023

Induction of Nestin-CreERT2 in neonatal mice directs extensive cre activity in cerebellum
Supplementary Figure S2 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Authors: Muranen Taru , Selfors Laura M. , Hwang Julie , Gallegos Lisa L. , Coloff Jonathan L. , Thoreen Carson C. , Kang Seong A. , Sabatini David M. , Mills Gordon B. , Brugge Joan S.
Published: April 2023

MYC and YAP expression mediate drug resistance towards PI3K/mTOR inhibition.
Supplementary Figure S1 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Authors: Muranen Taru , Selfors Laura M. , Hwang Julie , Gallegos Lisa L. , Coloff Jonathan L. , Thoreen Carson C. , Kang Seong A. , Sabatini David M. , Mills Gordon B. , Brugge Joan S.
Published: April 2023

Structurally diverse PI3K/mTOR inhibitors induce MYC and YAP up-regulation in resistant MCAS-R cells.
Supplemental Figure Legends from v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1
Authors: Ju Xiaoming , Jiao Xuanmao , Ertel Adam , Casimiro Mathew C. , Di Sante Gabriele , Deng Shengqiong , Li Zhiping , Di Rocco Agnese , Zhan Tingting , Hawkins Adam , Stoyanova Tanya , Andò Sebastiano , Fatatis Alessandro , Lisanti Michael P. , Gomella Leonard G. , Languino Lucia R. , Pestell Richard G.
Published: April 2023

Supplemental Figure 1. Trop2 ICD abundance is maintained by Src kinase. Supplemental Figure 2. Canertinib, a tyrosine kinase inhibitor targeting EGFR reduces cell proliferation but does not affect Trop2 ICD abundance. Supplemental Figure 3. Schematic representation of the mechanism by which Src induction of cyclin D1 enhances cleavage of the membrane associated Trop2 complex to thereby enhance Trop2 ICD. Supplemental Figure 4. Human prostate cancer Tissue Microarray (TMA) IHC staining.
Supplemental Figures and Reagent Table from Adaptive NK Cells with Low TIGIT Expression Are Inherently Resistant to Myeloid-Derived Suppressor Cells
Authors: Sarhan Dhifaf , Cichocki Frank , Zhang Bin , Yingst Ashley , Spellman Stephen R. , Cooley Sarah , Verneris Michael R. , Blazar Bruce R. , Miller Jeffrey S.
Published: April 2023

Supplemental figure. 1: Gating strategy of conventional and adaptive NK cells in healthy donors and MDS patients. Supplemental figure. 2: Gating strategy for MDSC and monocytes, CD16 expression on conventional and adaptive NK cells, expression of different NK cell receptors following co-culture with monocytes or MDSC, and differential production of IFNg on TIGIT high/low NK cells. Supplemental figure. 3: Evaluation of TIGIT blocking antibodies. IFNg production following DNAM-1 and TIGIT co-blocking. NK cell TNFa production in conventional and adaptive NK cells cultured with monocytes or MDSC. Supplemental Table. 1: All antibodies used throughout the study including clone, manufactory, fluorochrome, and marker.
Supplementary Table S3 from Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3′-Deoxy-3′-[18F]Fluorothymidine in Preclinical Models of Lung Cancer
Authors: Schelhaas Sonja , Held Annelena , Wachsmuth Lydia , Hermann Sven , Honess Davina J. , Heinzmann Kathrin , Smith Donna-Michelle , Griffiths John R. , Faber Cornelius , Jacobs Andreas H.
Published: April 2023

Mean and standard deviation, as well as number of samples analyzed (in brackets), of [18F]FLT uptake in organs other than the tumor 6 h after gemcitabine (%IDmax/mL)
Supplementary Tables from RNA Sequencing Identifies Transcriptionally Viable Gene Fusions in Esophageal Adenocarcinomas
Authors: Blum Andrew E. , Venkitachalam Srividya , Guo Yan , Kieber-Emmons Ann Marie , Ravi Lakshmeswari , Chandar Apoorva K. , Iyer Prasad G. , Canto Marcia I. , Wang Jean S. , Shaheen Nicholas J. , Barnholtz-Sloan Jill S. , Markowitz Sanford D. , Willis Joseph E. , Shyr Yu , Chak Amitabh , Varadan Vinay , Guda Kishore
Published: April 2023

Excel file containing Supplementary Tables 1-7 as follows: Supplementary Table 1 - Sample distribution in the discovery RNAseq cohort Supplementary Table 2 - Fusion transcripts detected in EACs in the discovery RNAseq cohort Supplementary Table 3 - Fusion transcripts detected in non-malignant samples in the discovery RNAseq cohort Supplementary Table 4 - Candidate fusion transcripts in EACs in the discovery RNAseq cohort Supplementary Table 5 - Sample distribution in the validation cohort Supplementary Table 6 - Candidate fusion frequencies in EACs in the discovery and validation cohorts Supplementary Table 7 - Candidate fusions found in both EAC and matched normal SQ tissues in the discovery cohort
Supplementary Methods from RNA Sequencing Identifies Transcriptionally Viable Gene Fusions in Esophageal Adenocarcinomas
Authors: Blum Andrew E. , Venkitachalam Srividya , Guo Yan , Kieber-Emmons Ann Marie , Ravi Lakshmeswari , Chandar Apoorva K. , Iyer Prasad G. , Canto Marcia I. , Wang Jean S. , Shaheen Nicholas J. , Barnholtz-Sloan Jill S. , Markowitz Sanford D. , Willis Joseph E. , Shyr Yu , Chak Amitabh , Varadan Vinay , Guda Kishore
Published: April 2023

Contains detailed experimental methods
Fig. S1 from Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells
Authors: Baghdadi Muhammad , Wada Haruka , Nakanishi Sayaka , Abe Hirotake , Han Nanumi , Putra Wira Eka , Endo Daisuke , Watari Hidemichi , Sakuragi Noriaki , Hida Yasuhiro , Kaga Kichizo , Miyagi Yohei , Yokose Tomoyuki , Takano Atsushi , Daigo Yataro , Seino Ken-ichiro
Published: April 2023

Effects of lung cancer cell culture supernatant on immune cells
Fig. S3 from TSC2 Deficiency Unmasks a Novel Necrosis Pathway That Is Suppressed by the RIP1/RIP3/MLKL Signaling Cascade
Authors: Filipczak Piotr T. , Thomas Cindy , Chen Wenshu , Salzman Andrew , McDonald Jacob D. , Lin Yong , Belinsky Steven A.
Published: April 2023

Nec-1 and NSA protect from canonical necroptosis induced with TNF-alpha/zVAD
Supplemental Materials and Methods from The NSL Chromatin-Modifying Complex Subunit KANSL2 Regulates Cancer Stem–like Properties in Glioblastoma That Contribute to Tumorigenesis
Authors: Ferreyra Solari Nazarena E. , Belforte Fiorella S. , Canedo Lucía , Videla-Richardson Guillermo A. , Espinosa Joaquín M. , Rossi Mario , Serna Eva , Riudavets Miguel A. , Martinetto Horacio , Sevlever Gustavo , Perez-Castro Carolina
Published: April 2023

Additional supporting experimental information.
Supplemental Tables 1 through 3 from HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology
Authors: Schache Andrew G. , Powell Ned G. , Cuschieri Kate S. , Robinson Max , Leary Sam , Mehanna Hisham , Rapozo Davy , Long Anna , Cubie Heather , Junor Elizabeth , Monaghan Hannah , Harrington Kevin J. , Nutting Christopher M. , Schick Ulrike , Lau Andy S. , Upile Navdeep , Sheard Jon , Brougham Kath , West Catharine M.L. , Oguejiofor Ken , Thomas Steve , Ness Andy R. , Pring Miranda , Thomas Gareth J. , King Emma V. , McCance Dennis J. , James Jacqueline A. , Moran Michael , Sloan Phil , Shaw Richard J. , Evans Mererid , Jones Terry M.
Published: April 2023

Supplementary Table S1. Age and gender comparison between the current study and the UK incidence data (2002-2011); Supplementary Table S2. Comparison of age distribution in cases from 2002-2006 vs. 2007-2011; Supplementary Table S3. Type-specific HPV prevalence among single infected HPV-positive tumours
Supplemental Figure S4 from The NSL Chromatin-Modifying Complex Subunit KANSL2 Regulates Cancer Stem–like Properties in Glioblastoma That Contribute to Tumorigenesis
Authors: Ferreyra Solari Nazarena E. , Belforte Fiorella S. , Canedo Lucía , Videla-Richardson Guillermo A. , Espinosa Joaquín M. , Rossi Mario , Serna Eva , Riudavets Miguel A. , Martinetto Horacio , Sevlever Gustavo , Perez-Castro Carolina
Published: April 2023

Figure S4. Higher self-renewal capacity of sorted G03 patient-derived cell.
Supplementary Table 8 from Improving the Performance of Somatic Mutation Identification by Recovering Circulating Tumor DNA Mutations
Authors: Fu Yu , Jovelet Cécile , Filleron Thomas , Pedrero Marion , Motté Nelly , Boursin Yannick , Luo Yufei , Massard Christophe , Campone Mario , Levy Christelle , Diéras Véronique , Bachelot Thomas , Garrabey Julie , Soria Jean-Charles , Lacroix Ludovic , André Fabrice , Lefebvre Celine
Published: April 2023

List of somatic mutations identified in the 93 breast cancer metastases
Supplementary Table 7 from Improving the Performance of Somatic Mutation Identification by Recovering Circulating Tumor DNA Mutations
Authors: Fu Yu , Jovelet Cécile , Filleron Thomas , Pedrero Marion , Motté Nelly , Boursin Yannick , Luo Yufei , Massard Christophe , Campone Mario , Levy Christelle , Diéras Véronique , Bachelot Thomas , Garrabey Julie , Soria Jean-Charles , Lacroix Ludovic , André Fabrice , Lefebvre Celine
Published: April 2023

Quality metrics for the whole-exome sequencing of the 93 pairs of tumor/blood from the metastatic breast cancer cohort (SAFIR01/MOSCATO) and the 60 pairs of tumor/blood from the MOSCATO trial.
Figure legends from The NSL Chromatin-Modifying Complex Subunit KANSL2 Regulates Cancer Stem–like Properties in Glioblastoma That Contribute to Tumorigenesis
Authors: Ferreyra Solari Nazarena E. , Belforte Fiorella S. , Canedo Lucía , Videla-Richardson Guillermo A. , Espinosa Joaquín M. , Rossi Mario , Serna Eva , Riudavets Miguel A. , Martinetto Horacio , Sevlever Gustavo , Perez-Castro Carolina
Published: April 2023

Figure legends
Supplementary Methods and Figure Legends from Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis
Authors: Mittal Deepak , Sinha Debottam , Barkauskas Deborah , Young Arabella , Kalimutho Murugan , Stannard Kimberley , Caramia Franco , Haibe-Kains Benjamin , Stagg John , Khanna Kum Kum , Loi Sherene , Smyth Mark J.
Published: April 2023

Supplementary Materials and Methods and Supplementary Figure Legends
Supplementary Table 2 from Improving the Performance of Somatic Mutation Identification by Recovering Circulating Tumor DNA Mutations
Authors: Fu Yu , Jovelet Cécile , Filleron Thomas , Pedrero Marion , Motté Nelly , Boursin Yannick , Luo Yufei , Massard Christophe , Campone Mario , Levy Christelle , Diéras Véronique , Bachelot Thomas , Garrabey Julie , Soria Jean-Charles , Lacroix Ludovic , André Fabrice , Lefebvre Celine
Published: April 2023

Details of the 1000 Genomes samples used in data simulation
Table S2 from Analysis of Liver Tumor-Prone Mouse Models of the Hippo Kinase Scaffold Proteins RASSF1A and SAV1
Authors: Zhang Xiaoying , Guo Cai , Wu Xiwei , Li Arthur X. , Liu Limin , Tsark Walter , Dammann Reinhard , Shen Hui , Vonderfecht Steven L. , Pfeifer Gerd P.
Published: April 2023

Supplemental Excel Table with gene lists for up- and downregulated genes
Table S1 from Analysis of Liver Tumor-Prone Mouse Models of the Hippo Kinase Scaffold Proteins RASSF1A and SAV1
Authors: Zhang Xiaoying , Guo Cai , Wu Xiwei , Li Arthur X. , Liu Limin , Tsark Walter , Dammann Reinhard , Shen Hui , Vonderfecht Steven L. , Pfeifer Gerd P.
Published: April 2023

Supplementary Excel Table with microarray data for the different mouse genotypes
Supplementary Table 12 from Improving the Performance of Somatic Mutation Identification by Recovering Circulating Tumor DNA Mutations
Authors: Fu Yu , Jovelet Cécile , Filleron Thomas , Pedrero Marion , Motté Nelly , Boursin Yannick , Luo Yufei , Massard Christophe , Campone Mario , Levy Christelle , Diéras Véronique , Bachelot Thomas , Garrabey Julie , Soria Jean-Charles , Lacroix Ludovic , André Fabrice , Lefebvre Celine
Published: April 2023

COSMIC variants identified in the plasma samples.
Supplementary Table 10 from Improving the Performance of Somatic Mutation Identification by Recovering Circulating Tumor DNA Mutations
Authors: Fu Yu , Jovelet Cécile , Filleron Thomas , Pedrero Marion , Motté Nelly , Boursin Yannick , Luo Yufei , Massard Christophe , Campone Mario , Levy Christelle , Diéras Véronique , Bachelot Thomas , Garrabey Julie , Soria Jean-Charles , Lacroix Ludovic , André Fabrice , Lefebvre Celine
Published: April 2023

ctDNA mutations identified by cmDetect in 60 TCGA breast cancer patients.
Supplementary Figure 1 from HTLV-1 Viral Factor HBZ Induces CCR4 to Promote T-cell Migration and Proliferation
Authors: Sugata Kenji , Yasunaga Jun-ichirou , Kinosada Haruka , Mitobe Yuichi , Furuta Rie , Mahgoub Mohamed , Onishi Chiho , Nakashima Kazutaka , Ohshima Koichi , Matsuoka Masao
Published: April 2023

Quantitative analyses of usHBZ and sHBZ transcripts in PBMCs of ATL patients.
A microarray analysis among 3-week-old WT SMG, TH-MYCN SMG, and TH-MYCN spheres from PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma
Authors: Tsubota Shoma , Kishida Satoshi , Shimamura Teppei , Ohira Miki , Yamashita Satoshi , Cao Dongliang , Kiyonari Shinichi , Ushijima Toshikazu , Kadomatsu Kenji
Published: April 2023

A microarray analysis among 3-week-old WT SMG, TH-MYCN SMG, and TH-MYCN spheres. The table contains data processing, probe information, and the list of genes in three groups, and the results of gene ontology analysis for each group.
A GSEA of E13.5 WT spheres and E13.5 TH-MYCN spheres from PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma
Authors: Tsubota Shoma , Kishida Satoshi , Shimamura Teppei , Ohira Miki , Yamashita Satoshi , Cao Dongliang , Kiyonari Shinichi , Ushijima Toshikazu , Kadomatsu Kenji
Published: April 2023

A gene set enrichement analysis (GSEA) of E13.5 WT spheres and E13.5 TH-MYCN spheres. The table contains the summary of GSEA, the list of gene sets enriched in either TH-MYCN spheres or WT spheres, the list of gene sets created by Ben-Porath et al., and the list of MYC-related gene sets.
Supplementary Methods, Table, and Legends from Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis
Authors: Young Arabella , Ngiow Shin Foong , Madore Jason , Reinhardt Julia , Landsberg Jennifer , Chitsazan Arash , Rautela Jai , Bald Tobias , Barkauskas Deborah S. , Ahern Elizabeth , Huntington Nicholas D. , Schadendorf Dirk , Long Georgina V. , Boyle Glen M. , Hölzel Michael , Scolyer Richard A. , Smyth Mark J.
Published: April 2023

This file contains Supplementary experimental Procedures, Supplementary Figure Legends, and Table S1. Table S1. Changes to patient CD73 expression following BRAF targeted therapy.
Supplementary Figure 7 from ARHGAP18 Downregulation by miR-200b Suppresses Metastasis of Triple-Negative Breast Cancer by Enhancing Activation of RhoA
Authors: Humphries Brock , Wang Zhishan , Li Yunfei , Jhan Jing-Ru , Jiang Yiguo , Yang Chengfeng
Published: April 2023

Western blot analysis of ZEB1, E-cadherin and PKCalpha in ARHGAP18 knockout, ARHGAP18 re-expression, miR-200b stable expression and miR-200b-ARHGAP18 double stable expression cells and a schematic summary of the mechanism of miR-200b inhibition of TNBC cell migration and tumor metastasis
Supplementary Information from TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma
Authors: Ng Kai-Yu , Chan Lok-Hei , Chai Stella , Tong Man , Guan Xin-Yuan , Lee Nikki P , Yuan Yunfei , Xie Dan , Lee Terence K , Dusetti Nelson J , Carrier Alice , Ma Stephanie
Published: April 2023

Supplementary Tables 1-3 contains primer sequences for qPCR, luciferase reporter and ChIP assays. Figure Legends for Supplementary Figures 1-4 are also included.
Figure S4 from TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma
Authors: Ng Kai-Yu , Chan Lok-Hei , Chai Stella , Tong Man , Guan Xin-Yuan , Lee Nikki P , Yuan Yunfei , Xie Dan , Lee Terence K , Dusetti Nelson J , Carrier Alice , Ma Stephanie
Published: April 2023

pERK1/2, DUSP10 and p73 immunohistochemical staining of xenograft tumors generated from HCC cells with and without TP53INP1 stably repressed.
Figure S3 from Loss of Tumor Suppressor STAG2 Promotes Telomere Recombination and Extends the Replicative Lifespan of Normal Human Cells
Authors: Daniloski Zharko , Smith Susan
Published: April 2023

Figure S3 provides analysis of telomere cohesion, telomere sister chromatid exchange, growth, DNA damage, senescence, telomere length, and aneuploidy of BJ-1 and BJ-2 SA2-depleted stable cell lines and relates to Figure 6.
Supplementary Table S1 from Autocrine BMP-4 Signaling Is a Therapeutic Target in Colorectal Cancer
Authors: Yokoyama Yuichiro , Watanabe Toshiaki , Tamura Yusuke , Hashizume Yoshinobu , Miyazono Kohei , Ehata Shogo
Published: April 2023

Primer sequences for PCR analyses.
Supplementary Figures S1 through S10 from Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells
Authors: Sukumar Selvakumar , Wilson Douglas C. , Yu Ying , Wong Jerelyn , Naravula Saraswathi , Ermakov Grigori , Riener Romina , Bhagwat Bhagyashree , Necheva Antoaneta S. , Grein Jeff , Churakova Tatyana , Mangadu Ruban , Georgiev Peter , Manfra Denise , Pinheiro Elaine M. , Sriram Venkataraman , Bailey Wendy J. , Herzyk Danuta , McClanahan Terrill K. , Willingham Aarron , Beebe Amy M. , Sadekova Svetlana
Published: April 2023

Supplementary Figure S1 shows the gating scheme and markers used to phenotype various T cell subsets in human blood. Supplementary Figure S2 shows the expression of GITR on human and cynomolgus monkey NK cells and T cells. Supplementary Figure S3 shows the expression of GITR on various human tumor infiltrating T cell subsets. Supplementary Figure S4 shows the phenotypic and functional characterization of CD4+ CD25+ TILs from NSCLC tumor tissues. Supplementary Figure S5 shows the phenotypic and functional characterization of iTregs generated in MLR cultures. Supplementary Figure S6 shows the differential effects of MK-4166 when added to MLR cultures on Day 0 vs Day 7. Supplementary Figure S7 shows the potential of MK-4166 to induce ADCC when bound to human iTregs. Supplementary Figure S8 shows the attenuation of nTreg suppression by MK-4166. Supplementary Figure S9 shows the purity of enriched nTregs used in Treg suppression assays. Supplementary Figure S10 shows the effect of MK-4166 on nTreg proliferation.
Supp Methods from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation
Authors: Bhagat Tushar D. , Chen Si , Bartenstein Matthias , Barlowe A. Trevor , Von Ahrens Dagny , Choudhary Gaurav S. , Tivnan Patrick , Amin Elianna , Marcondes A. Mario , Sanders Mathijs A. , Hoogenboezem Remco M. , Kambhampati Suman , Ramachandra Nandini , Mantzaris Iaonnis , Sukrithan Vineeth , Laurence Remi , Lopez Robert , Bhagat Prafulla , Giricz Orsi , Sohal Davendra , Wickrema Amittha , Yeung Cecilia , Gritsman Kira , Aplan Peter , Hochedlinger Konrad , Yu Yiting , Pradhan Kith , Zhang Jinghang , Greally John M. , Mukherjee Siddhartha , Pellagatti Andrea , Boultwood Jacqueline , Will Britta , Steidl Ulrich , Raaijmakers Marc H.G.P. , Deeg H. Joachim , Kharas Michael G. , Verma Amit
Published: April 2023

Supplementary Methods
Supplementary figures and figure legends from Liver Metastasis Is Facilitated by the Adherence of Circulating Tumor Cells to Vascular Fibronectin Deposits
Authors: Barbazán Jorge , Alonso-Alconada Lorena , Elkhatib Nadia , Geraldo Sara , Gurchenkov Vasily , Glentis Alexandros , van Niel Guillaume , Palmulli Roberta , Fernández Beatriz , Viaño Patricia , Garcia-Caballero Tomas , López-López Rafael , Abal Miguel , Vignjevic Danijela Matic
Published: April 2023

Supplementary Figure S1: CTCs from mCRC patients display and adhesive-like gene expression pattern enriched in focal adhesion components; Supplementary Figure S2: Collagen I and IV are absent in the luminal side of vascular endothelium; Supplementary Figure S3: Liver fibronectin is upregulated in primary tumor bearing mice; Supplementary Figure S4: Luminal fibronectin deposits are present after liver blood perfusion; Supplementary Figure S5: Intravascular fibronectin deposits are present in human livers bearing metastasis from colon cancer; Supplementary Figure S6: Cancer cells display paxillin-GFP aggregates that colocalize with hepatic vascular fibronectin in vivo; Supplementary Figure S7: Validation of talin1 knockdown as a model for focal adhesion-depletion; Supplementary Figure S8: Focal adhesion-impaired cells determine adhesion to different ECM substrates and HUVEC cells; Supplementary Figure S9: Endothelial cell retraction induced by cancer cells; Supplementary Figure S10: Talin1 knockdown does not alter cell viability/proliferation in vitro; Supplementary Figure S11: Intravascular fibronectin deposits are also present in mesenteric blood vessels.
Table and material & methods from Targeting Vascular Endothelial-Cadherin in Tumor-Associated Blood Vessels Promotes T-cell–Mediated Immunotherapy
Authors: Zhao Yang , Ting Ka Ka , Li Jia , Cogger Victoria C. , Chen Jinbiao , Johansson-Percival Anna , Ngiow Shin Foong , Holst Jeff , Grau Georges , Goel Shom , Muller Thorleif , Dejana Elisabetta , McCaughan Geoff , Smyth Mark J. , Ganss Ruth , Vadas Mathew A. , Gamble Jennifer R.
Published: April 2023

Supplemental- Material and Methods
Movie S1 from Liver Metastasis Is Facilitated by the Adherence of Circulating Tumor Cells to Vascular Fibronectin Deposits
Authors: Barbazán Jorge , Alonso-Alconada Lorena , Elkhatib Nadia , Geraldo Sara , Gurchenkov Vasily , Glentis Alexandros , van Niel Guillaume , Palmulli Roberta , Fernández Beatriz , Viaño Patricia , Garcia-Caballero Tomas , López-López Rafael , Abal Miguel , Vignjevic Danijela Matic
Published: April 2023

Movie S1 from Liver Metastasis Is Facilitated by the Adherence of Circulating Tumor Cells to Vascular Fibronectin Deposits
FigS1,FigS2,FigS3,FigS4,FigS5,FigS6 from Targeting Vascular Endothelial-Cadherin in Tumor-Associated Blood Vessels Promotes T-cell–Mediated Immunotherapy
Authors: Zhao Yang , Ting Ka Ka , Li Jia , Cogger Victoria C. , Chen Jinbiao , Johansson-Percival Anna , Ngiow Shin Foong , Holst Jeff , Grau Georges , Goel Shom , Muller Thorleif , Dejana Elisabetta , McCaughan Geoff , Smyth Mark J. , Ganss Ruth , Vadas Mathew A. , Gamble Jennifer R.
Published: April 2023

Figure S1 Dose response of CD5-2 in B16F10 tumor model Figure S2 CD5-2 penetrates into endothelial cells but has no effect on proliferation, senescence and migration in vitro. Figure S3 CD5-2 does not affect tumor cell proliferation, necrosis, senescence and number of leukocytes infiltrating into the B16F10 tumor. Figure S4 CD5-2 has effects on CD8+ T cells but no effect on CD4+ T cells or NKp46+ NK cells in the MC38 tumor. Figure S5 CD5-2 increases VE-cadherin expression and regulates tight junctions pathway. Figure S6 schematic diagram of proposed effects of CD5-2 on tumor microenvironment.
Supplementary Tables S1-S3 from SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells
Authors: Kurtsdotter Idha , Topcic Danijal , Karlén Alexandra , Singla Bhumica , Hagey Daniel W. , Bergsland Maria , Siesjö Peter , Nistér Monica , Carlson Joseph W. , Lefebvre Veronique , Persson Oscar , Holmberg Johan , Muhr Jonas
Published: April 2023

This file contains Tables S1-S3. Table S1 shows number of injected mice and tumor incidence. Table S2 shows genes and fold changes of commonly up and down regulated genes in mouse Sox5/6/21fl/fl tumors and human GBM. Table S3 shows Sox21 ChIPseq peaks association to nearest gene.
Supplementary Table S1 from Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor
Authors: Gustafsson Robert , Jemth Ann-Sofie , Gustafsson Nina M.S. , Färnegårdh Katarina , Loseva Olga , Wiita Elisée , Bonagas Nadilly , Dahllund Leif , Llona-Minguez Sabin , Häggblad Maria , Henriksson Martin , Andersson Yasmin , Homan Evert , Helleday Thomas , Stenmark Pål
Published: April 2023

Buffers for MTHFD2 and MTHFD1 DC-domain lysis, purification and inhibition assay.
Supplementary Figures 1-6 from The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1-Mutant Cancers and Potentiates NAD+ Depletion–Mediated Cytotoxicity
Authors: Tateishi Kensuke , Higuchi Fumi , Miller Julie J. , Koerner Mara V.A. , Lelic Nina , Shankar Ganesh M. , Tanaka Shota , Fisher David E. , Batchelor Tracy T. , Iafrate A. John , Wakimoto Hiroaki , Chi Andrew S. , Cahill Daniel P.
Published: April 2023

'Temozolomide induced PARP activation deregulates NAD metabolism. Additive cytotoxic effect of TMZ and NAMPT inhibitors in IDH1 mutant cancers. NAD and cell viability effects with TMZ and NAMPT inhibitors in endogenous IDH1 mutant cancers. Combination treatment with TMZ and NAMPT inhibitor in IDH1 mutant and wild-type cells. Cell death mechanisms that underlie combined TMZ and NAMPT inhibitor treatment in IDH1 mutant cells. In vivo effects of combined TMZ and NAMPT inhibitor treatment for endogenous IDH1 mutant cancer.'
Supplementary Figure Legends from The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1-Mutant Cancers and Potentiates NAD+ Depletion–Mediated Cytotoxicity
Authors: Tateishi Kensuke , Higuchi Fumi , Miller Julie J. , Koerner Mara V.A. , Lelic Nina , Shankar Ganesh M. , Tanaka Shota , Fisher David E. , Batchelor Tracy T. , Iafrate A. John , Wakimoto Hiroaki , Chi Andrew S. , Cahill Daniel P.
Published: April 2023

''Temozolomide induced PARP activation deregulates NAD metabolism. Additive cytotoxic effect of TMZ and NAMPT inhibitors in IDH1 mutant cancers. NAD and cell viability effects with TMZ and NAMPT inhibitors in endogenous IDH1 mutant cancers. Combination treatment with TMZ and NAMPT inhibitor in IDH1 mutant and wild-type cells. Cell death mechanisms that underlie combined TMZ and NAMPT inhibitor treatment in IDH1 mutant cells. In vivo effects of combined TMZ and NAMPT inhibitor treatment for endogenous IDH1 mutant cancer.''
Table S1 to S3 from Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis
Authors: Tang Yun-Chi , Yuwen Hui , Wang Kaiying , Bruno Peter M. , Bullock Kevin , Deik Amy , Santaguida Stefano , Trakala Marianna , Pfau Sarah J. , Zhong Na , Huang Tao , Wang Lan , Clish Clary B. , Hemann Michael T. , Amon Angelika
Published: April 2023

Table S1: Summary of compound effect in aneuploid Ts13 MEF compared to euploid wild-type MEF. Table S2: shRNA and siRNA sequences used in this study. Table S3: Primers used for quantitative Real-Time PCR.
Supplemental Figure 7 from Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis
Authors: Tang Yun-Chi , Yuwen Hui , Wang Kaiying , Bruno Peter M. , Bullock Kevin , Deik Amy , Santaguida Stefano , Trakala Marianna , Pfau Sarah J. , Zhong Na , Huang Tao , Wang Lan , Clish Clary B. , Hemann Michael T. , Amon Angelika
Published: April 2023

Expression of ceramide anabolizing and catabolizing enzymes in MIN and CIN colorectal cells upon DL-PDMP treatment.
Supplemental Figure 6 from Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis
Authors: Tang Yun-Chi , Yuwen Hui , Wang Kaiying , Bruno Peter M. , Bullock Kevin , Deik Amy , Santaguida Stefano , Trakala Marianna , Pfau Sarah J. , Zhong Na , Huang Tao , Wang Lan , Clish Clary B. , Hemann Michael T. , Amon Angelika
Published: April 2023

Sphingolipid composition of aneuploid and euploid cell lines upon DL-PDMP treatment.
Supplemental Figure 4 from Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis
Authors: Tang Yun-Chi , Yuwen Hui , Wang Kaiying , Bruno Peter M. , Bullock Kevin , Deik Amy , Santaguida Stefano , Trakala Marianna , Pfau Sarah J. , Zhong Na , Huang Tao , Wang Lan , Clish Clary B. , Hemann Michael T. , Amon Angelika
Published: April 2023

UGCG and SGMS1 knockdown efficiencies with different shRNA and siRNA.