bluuebunny/crossref_metadata_2025 huggingface dataset:
ADAPTATION POTENTIAL STRUCTURE IN GIFTED ADOLESCENTS
Authors: Andronnikova O. O. , Perevozkina Yu. M. , Dmitrieva N. V. , Shchukina N. A.
Published: January 2018

The article reflects the main approaches to the problem of adaptive potential. It featured the essence and content of the adaptive potential of modern psychology and analyzes the structural components of the adaptation potential, including neuropsychic stability, self-esteem, communicativity, psychic regulation, etc. The paper describes the features of adaptation of gifted adolescents and the structure of the adaptive potential, which is represented as a multi-level system. It is suggested that the structure of the adaptive potential of gifted adolescents includes emotional, reflexive, volitional and behavioral components. The test subjects were gifted adolescents aged 12–15, studying in specialized classes (engineering). The group included 56 people, 26 boys and 20 girls. The article describes the data of factor analysis by the method of principal components with rotation "varimax normalized". The analysis has demonstrated that the structure of the adaptive potential of gifted adolescents includes five factors explaining 57.02 % of the total variability. The results of factor analysis allow the authors to come to the conclusion that the adaptive potential of gifted adolescents includes five components: 1 and 2 components reflect the emotional component, i.e. the ability to understand how to express your feelings and feelings of others; 3 – reflexive component, i.e. ability to internal analysis of their actions and actions; 4 – behavioral component, i.e. propensity to react in a certain way to a particular situation; 5 – strong-willed component, i.e.  ability to regulate one’s emotional behavior in unusual situations.
DEPENDENCE OF AFFIRMATION EFFECTS ON THE EMOTIONAL COLORING OF THE OBJECT
Authors: Yanovsky M. I.
Published: January 2018

The current paper features an attempt at a new interpretation of the affirmation phenomena introduced by D. N. Uznadze. The author considers the process of affirmation forming as the implementation of measurement actions. The idea is that measurement actions, in addition to their direct function, also structure the background perceptual space (which is believed to shape the cognitive medium of perception images). Distortions of the measurement procedure, in one way or another, correlate with different forms of structuring the background perceptual space and with its increasing role in emotional coloring. The article describes an experiment in which the objects were not only perceived and evaluated, but also influenced the accuracy of the perception of objects, since they "control" the forms of the structuring of the background space and give it an emotional coloring. The experiment was carried out according to a procedure similar to the classical experiment conducted by D. N. Uznadze. The experiment featured an illusion of affirmation formation through the multiple presentation of circles of different diameters. We used circles of the same size, but with different versions of images inside: an emotionally colored image ("smileys"), ordered emotional ("triangles"), disordered emotionless ("chaotic points"). As a result, the emotionally colored image inside the circles caused an increase in the number of errors in the comparison of the circles, and the ordered, non-emotional image increased the accuracy of perception.
SEMANTICS AND PRAGMATICS OF VERBAL METAPHOR OF FOOD (THE SEMANTIC GROUP «FOOD CONSUMPTION WITH THE AID OF TEETH»)
Authors: Zhivago N. A.
Published: January 2018

The article features an analysis of semantics, pragmatics and text-based functioning of figurative vocabulary and expressions, which are metaphorically motivated by such verbs as bite, gnaw, nibble and chew. These verbs name various activities, processes and phenomena because of their analogy to food consumption with the aid of teeth. The analysis allowed the author to describe a number of cognitive metaphorical models which, in their turn, reflect the image projection from the source-domain “Food Consumption” into the conceptual spheres of physiological, mental, psychological and social phenomena. The given system of images expresses metaphorically the concept of various processes and notions related to deformation, destruction and disappearance of material objects; destructive effects on the human body and psyche; social and moral pressure (e. g. competitive struggle, repressive political system), loss of physical resources and values. The pragmatic potential of the image-bearing vocabulary and expressions is predominantly related to negative evaluative connotation since they reveal disapproving, condemning, contemptuous emotional attitude and high level of expressivity.
THE KOLYVAN FACTORIES IN THE POLICY OF THE KUZNETSK VOIVODES IN THE SECOND QUARTER OF THE XVIII CENTURY
Authors: Bobrov D. S.
Published: January 2018

The article is devoted to the identification and analysis of the areas of interaction between the Kuznetsk voivodes (governors) and proprietary estate managers of the A. N. Demidov’s Kolyvan factories in the second quarter of the XVIII century. The research is based on unpublished documents from the funds of the Russian State Archive of Ancient Acts. The article features the reaction of the district administrators to the establishment and dynamics of the security system at copper smelteries in the interstream area between the Ob and the Irtysh. The system contradictions between the interests of civil authorities and A. N. Demidov’s managers are demonstrated by the example of the use of state-owned salt, as well as by the amenability of crimes. The resulting collisions and conflicts are considered as a consequence of the unregulated procedure of the relationship of the relevant administrative subject in lawmaking and administration. The author casts doubt on the popular opinion that there was no competition between the state and the proprietary basics in the development of the Upper Ob-Irtysh area. The author comes to a conclusion about the permanent aspiration of the Kuznetsk voivodes to expand their administrative influence on the estate managers of the Kolyvan-Voskresensky department.
WHY DID MERCHANTS IN TRADITIONAL CHINA NEED AN ACADEMIC TITLE?
Authors: Danshin A. V.
Published: January 2018

The article explores the issue of participation of the traditional China merchant class in special examinations that gave the right to work in the state authorities. The author’s aim was to find the answer to the following question: why were merchants banned from the exams, whereas artisans and peasants were granted this opportunity. When they were finally given such an option, it immediately resulted in a huge wave of applicants willing to pass the difficult test, despite its great material and moral costs and the fact that there was no guarantee that the applicant could ever become a government official to become officials, even if they passed the ordeal with flying colors. The author concludes that for most of the applicants the main purpose was not the bureaucratic post itself but the degree that allowed them to enter the ranks of the privileged scholar class shênshih (绅士) and become part of the political elite of Chinese society, which gave them more opportunities to develop their trading business.
RIGHT-WING POPULIST REGIONAL MOVEMENTS IN GERMANY
Authors: Antonov A. E. , Korneva L. N.
Published: January 2018

The article is devoted right-wing populist movements in Germany, which are the direct consequence of the crisis of multicultural community. In their propaganda they speculate on the mood in the society, using Islamophobia as their main weapon. The phenomenon of Islamophobia, or criticism of Islam, as well as the fight against its growing influence, has been heating up on the territory of the EU and, in particular, in Germany, where it is connected with Muslim immigrants. The right-wing movements bring the refugee issue into focus of public attention to strengthen their position in the current political landscape. The subject of the research is the most active and significant right-wing populist movements in modern Germany. The article defines the term of right-wing populism, as well as the most favorable conditions for its occurrence. The paper features the history, political activity and the ideology of the right-wing populist movements in Germany. It also offers a brief outlook on the degree of influence of anti-Islamic attitude in the European and German society.
ECOLOGICAL MUSEUM "THE TYULBERSKY GORODOK" AS AN EDUCATIONAL AND SCIENTIFIC CENTER FOR ETHNOECOLOGICAL RESEARCH OF THE TOM’ RIVER VALLEY
Authors: Kimeev V. M. , Golubev M. E. , Nevzorov B. P.
Published: January 2018

The current research features the concept behind the Ethnic and Ecological Museum "The Tyulbersky gorodok" and gives a retrospective view of its history. The main distinctive feature of the museum is that, unlike other ecomuseums of the Tom’ River valley within the Culture of Kuzbass program, it owes its existence to a confluence of favorable circumstances. It emerged due to the resolute actions of the local archeologists and ethnographers, the patriotic sentiments of the former leaders of the Kemerovo district, the support of the JSC Kuzbassenergo of the Northern Electrical Networks, the Kemerovo state University, the professional work of architects and designers and the skill of the conservation specialists in carpentry. The initial stage of its development involved the archeological excavations and studies on the local flora and fauna performed by the KemSU academic staff and students. Kuzbass school students participated in the Educational scientific center of the ethnoecological researches "Gorodok". In 1998 university students had their first field practice in the camp created with the financial support from the Northern Networks. The second stage was the official opening of the eco-museum in 2003. It achieved the following official status: municipal budgetary institution of the Kemerovo municipal district Ethnic and Ecological Museum "The Tyulbersky gorodok" with temporary preservation of the Educational scientific center of the ecomuseum and KemSU on the basis of the Contracts on cooperation and joint activity (2003, 2005 and 2007).
Analysis of impacts of polders on flood processes in Qinhuai River Basin, China, using the HEC-RAS model
Authors: Gao Yuqin , Yuan Yu , Wang Huaizhi , Zhang Zhenxing , Ye Liu
Published: January 2018

Flood control with polders is prevalent in East China. Their impact on flood processes is critically important for flood control, but has not been well documented. The Qinhuai River Basin was selected as the study area. A Hydrologic Engineering Center – River Analysis System (HEC-RAS) hydraulic model was developed to simulate and predict storm flood processes and the associated impact of polders. The study shows that the HEC-RAS model is capable of simulating the impact of polders on flood processes in the Qinhuai River Basin. The polders increased the water level outside of the polders. The polders in upstream watersheds have a greater impact on the water level than polders close to basin outlets when individually distributed. The maximum water level at Dongshan section shows an increasing trend for different sized flood with the increasing number of polders in the basin, and a linear increasing trend associated with urbanization. The smaller the flood scale is, the greater the maximum water level changes.
The effect of mixing on fermentation of primary solids, glycerol, and biodiesel waste
Authors: Ghasemi Marzieh , Randall Andrew A.
Published: January 2018

In this study, the effect of mixing on volatile fatty acid (VFA) production and composition was investigated through running five identical bench-scale reactors that were filled with primary solid and dosed with either pure glycerol or biodiesel waste. Experimental results revealed that there was an inverse correlation between the mixing intensity and the VFA production. The total VFA production in the un-mixed reactor was 9,787 ± 3,601 mg COD/L, whereas in the reactor mixed at 100 rpm this dropped to 3,927 ± 1,175 mg COD/L, while both types of reactor were dosed with pure glycerol at the beginning of each cycle to reach the initial concentration of 1,000 mg/L (1,217 mg COD/L). Propionic acid was the dominant VFA in all the reactors except the reactor mixed at 30 rpm. It is hypothesized that low mixing facilitated hydrogen transfer between obligate hydrogen producing acetogens (OHPA) and hydrogen consuming acidogens in these non-methanogenic reactors. Also, in a narrower range of mixing (0 or 7 rpm), the total VFA production in biodiesel waste-fed reactors was considerably higher than that of pure glycerol-fed reactors.
Izrael jako mesjańska Mądrość i jej świadectwo pośród narodów w Iz 55,3-5. Studium egzegetyczo-historyczne
Authors: Zawadzki Arnold
Published: January 2018

The article tries to describe the theology of David’s testimony in Isaiah55:3-5 in light of its historical background, to wit the last decade of theBabylonian exile, and in relation to the internal quandary of Judean Exiles.The study undertakes an inquiry into the question of whether the eternalcovenant in Isaiah 55:3-5 is the continuation of the Sinaitic Covenant, orrather does its content go beyond the Mosaic Law, creating a totally newrelationship of God with Israel. The study also draws attention to the existenceof a redactional addition, which swifts the weight of the originalmessage from a revanchist Judeo-centrism toward the irenic ethnic-centrismtypical of the Book of Jonah.
Marian MAŁECKI, Z Ziemi Świętej do Polski. Dzieje Bożogrobców. From Holy Land to Poland. The History of the Order of the Holy Sepulcre, Zakon Rycerski Świętego Grobu Bożego w Jerozolimie: Zwierzchnictwo w Polsce – Drukarnia Archidiecezjalna w Katowicach, 2013, ss. 159.
Authors: Chrostowski Waldemar
Published: January 2018

recenzja
Sylwia SURDYKOWSKA (red.), Orientalistyka. Rozważania o nauce, Wydawnictwa Uniwersytetu Warszawskiego, Warszawa 2015, ss. 206.
Authors: Chrostowski Waldemar
Published: January 2018

recenzja
Ks. Leonard FIC, Buddyzm w kulturze Zachodu, Religie Świata – Świat Religii 18, Wydawnictwo „Polihymnia”, Lublin 2016, ss. 240.
Authors: Szuppe Paweł
Published: January 2018

recenzja
Non-Viral Vectors for Gene Delivery
Authors: Bansal Aparna , Himanshu
Published: January 2018

Introduction:

Gene therapy has emerged out as a promising therapeutic pave for the treatment of genetic and acquired diseases. Gene transfection into target cells using naked DNA is a simple and safe approach which has been further improved by combining vectors or gene carriers. Both viral and non-viral approaches have achieved a milestone to establish this technique, but non-viral approaches have attained a significant attention because of their favourable properties like less immunotoxicity and biosafety, easy to produce with versatile surface modifications, etc. Literature is rich in evidences which revealed that undoubtedly, non–viral vectors have acquired a unique place in gene therapy but still there are number of challenges which are to be overcome to increase their effectiveness and prove them ideal gene vectors.

Conclusion:

To date, tissue specific expression, long lasting gene expression system, enhanced gene transfection efficiency has been achieved with improvement in delivery methods using non-viral vectors. This review mainly summarizes the various physical and chemical methods for gene transfer in vitro and in vivo.
Counting the Casualties of Telecom: The Adoption of Part 6 of the Telecommunications ACT 1997 (CTH)
Authors: Lee Karen
Published: January 2018

The concept of self-regulation in all of its forms has become a foundation stone in the theoretical and practical debates about the role and function of the modern ‘decentred’ regulatory state. In the decentred state, government, among other things, ceases to rely upon the old tool of ‘command and control’ regulation to achieve social policy goals. Instead, government relies on alternative systems developed by industry and others and faces the arguably more daunting challenge of trying to harness the internal regulatory capacity of these other regulatory systems, directing and steering them in a way that ensures they deliver the goods and services sought by society in accordance with accepted social values. Although the focus of the theoretical regulatory debate has started to shift to the meta-regulatory potential of law and the ability of government to ‘regulate self-regulation’, the question of how and why self-regulatory rule-making regimes actually emerge remains largely unexplored from an empirical standpoint.
Slaying the Ghost of Henry VIII: A Reconsideration of the Limits upon the Delegation of Commonwealth Legislative Power
Authors: Ng Gerald
Published: January 2018

Though at times inconvenient for lawyers and their clients, the use by the Commonwealth of delegated legislation to fill lacunae in statutes is hardly remarkable, and the constitutional validity of provisions authorising that use even less a matter of controversy. Nonetheless, there may be reason to doubt whether the same can so readily be said of the inclusion in Commonwealth statutes of so-called ‘Henry VIII’ clauses – that is, statutory provisions purporting to authorise the promulgation of subordinate legislation that either amends or is inconsistent with the relevant principal statute. In particular, one might ask to what extent such provisions may, regardless of their width, be accommodated within the distribution of power contemplated by the text and structure of the Constitution.

The task of answering this question requires, as a first step, that fresh consideration be given to the limits, if any, upon Parliament’s ability to confer on other institutions some part of the legislative power of the Commonwealth.
The Resolution of Inconsistent State and Territory Legislation
Authors: Lindell Geoffrey , Mason Anthony
Published: January 2018

It is a great pleasure to contribute to a festschrift devoted to celebrating the 80th anniversary of our friend and colleague, Emeritus Professor Leslie Zines. His contribution to the study of Australian constitutional law is too well known to require any reinforcement from us. It spans a period of five decades. His principal book The High Court and the Constitution has been and continues to be at the forefront of constitutional scholarship since it was first published. That book and his other writings represent the distilled essence of much of his valuable and incisive understanding of the way the High Court interprets and should interpret, the Constitution – something which has held a life-long fascination for him. In his publications as in his many years of teaching, he displays not only a mastery of the technical and analytical aspects of public law, but a social and functional awareness that goes well beyond deriving the meaning and application of many provisions of the Constitution by the mere contemplation of the language used or by the canons of construction.
MICROLEAKAGE EVALUATION OF MODIFIED MINERAL TRIOXIDE AGGREGATE EFFECT TOWARD MARGINAL ADAPTATION ON CERVICAL DENTIN PERFORATION
Authors: Dewi Feryariska , Asrianti Dini , Margono Anggraini
Published: January 2018

Objective: To analyze the marginal adaptation of conventional MTA (ProRoot®MTA) and modified MTA (MTA Flow™) on perforated dentin.Methods: Forty specimens of human’s premolar teeth with lateral perforations were sealed by conventional MTA (n=20) and modified MTA (n=20). After 24 hours, the specimens were immersed in Indian ink for 24 hours, then embedded in resin and sectioned longitudinally in mesial-distal direction. The score of microleakage was determined using stereo microscope (SteREO Discovery. V12, Carl Zeiss) with 20x magnification. Statistical analysis was done by Chi Square (p<0,05).Results: Less microleakage score (0,5-1mm) was detected in modified MTA (25%) compared to conventional MTA (45%), although not statistically significant.Conclusion: Microleakage were detected in both conventional and modified MTA as material for cervical dentin perforation treatment, although modified-MTA group showed less microleakage score.
EFFECTS OF A 980-NM DIODE LASER’S ACTIVATION OF 2.5% NAOCL AND 2% CHLORHEXIDINE ANTIFUNGAL IRRIGATION SOLUTIONS ON CANDIDA ALBICANS BIOFILMS
Authors: Iselinni Chitra , Meidyawati Ratna , Djauharie Nilakusuma
Published: January 2018

Objective: Candida albicans is the most frequently found fungi in persistent root canal infections; it can form a biofilm and penetrate into dentinal tubules. Endodontic irrigants, such as 2.5% sodium hypochlorite (NaOCl) and 2% chlorhexidine (CHX), have antifungal properties, but limited penetration into dentinal tubules, which somewhat protects the C. albicans fungi. The use of a diode laser is an innovative approach in root canal treatments because it is able to penetrate deeper into the dentinal tubules. This study examined the effect of a 980-nm diode laser on the antifungal properties of 2.5% NaOCl and 2% CHX on C. albicans biofilms.Methods: The number of C. albicans colonies in the biofilms was recorded after irrigation using 2.5% NaOCl and 2% CHX. Then, the biofilms were radiated using a 980-nm diode laser.Results: Showed statistically significant differences between the use of the irrigants only and the use of the irrigants plus the diode laser treatment in the reduction of the C. albicans colonies in the biofilm.Conclusion: Diode laser is able to activate the antifungal properties of the 2.5% NaOCl and 2% CHX endodontic irrigants.
ROOT COVERAGE USING THE SUBEPITHELIAL CONNECTIVE TISSUE GRAFT OR THE ACELLULAR DERMAL MATRIX FOR THE TREATMENT OF GINGIVAL RECESSION: A CLINICAL STUDY
Authors: Sumana Shula Zuleika , Masulili Sri Lelyati C , Lessang Robert
Published: January 2018

Objective: This study aims to evaluate periodontal clinical conditions after treatment for gingival recession (GR) using subepithelial connective tissue graft (SCTG) and acellular dermal matrix (ADM).Methods: Ten patients with Miller’s Class I and II recessions that had been treated with SCTG or ADM at the Periodontics Outpatient Department at Universitas Indonesia were selected for this study. The pre-operative data for GR, clinical attachment levels (CAL), and attached gingiva (AG) were retrieved from the patients’ medical records. The patients were recalled and the post-operative data were recorded.Results: The application of SCTG and ADM yields significant changes to GR, CAL, and AG levels. A comparison of two groups at the post-operative assessment stage showed no statistically significant differences, in terms of GR, CAL, and AG.Conclusion: SCTG and ADM yield similar outcomes in the treatment of GR. As such, ADM may be suggested as an alternative to SCTG for root coverage.
CYTOTOXICITY OF IONS RELEASED FROM 17-4 PRECIPITATION HARDENING STAINLESS STEEL ORTHODONTIC BRACKETS IN ARTIFICIAL SALIVA
Authors: Prasetyadi Tjokro , Irawan Bambang , Purwanegara Miesje Karmiati , Suharno Bambang , Supriadi Sugeng
Published: January 2018

Objective: 17-4 precipitation hardening (PH) stainless steel has a low nickel content, which can reduce the risk of allergic reactions. It also has good mechanical properties against the stress caused by the archwire slot brackets in orthodontic treatments. The main focus of this study to evaluate the metal ions released into artificial saliva from different orthodontic brackets with the same 17-4 PH stainless steel and to examine the in vitro cytotoxicity of the metal.Methods: Material properties were analyzed by energy dispersive spectroscopy. The 3-(4,5-dimethylthiazol-2-y1)2,5-diphenyltetrazolium bromide (MTT) assay method was used to examine the cytotoxicity of Gemini and Synergy brackets.Results: The cytotoxicity test on all the orthodontic brackets showed a mean cell viability value above 80% in each immersion group, which means that this material is not cytotoxic to the human immortalized keratinocyte cell line.Conclusions: The results showed cell viability in the extracts of both groups of brackets, and there was no statistically significant difference between the groups (p>0.05).
THREE-DIMENSIONAL MODEL PRINTING IN ORAL AND MAXILLOFACIAL RECONSTRUCTIVE SURGERY: COMPARISON OF THREE-DIMENSIONAL MODELS AND MULTISLICE COMPUTED TOMOGRAPHY SCANS
Authors: Latief Adhitya , Suhardi Pradono , Badri Cholid
Published: January 2018

Objective: The objective of this study is to compare fabrication of commonly used three-dimensional (3D) models with original multislice computed tomography (MSCT) scan data for accuracy and precision in reconstruction surgery.Methods: MSCT data from 10 samples are processed and manufactured to be 3D models. Both groups are then measured and analyzed for the purpose of comparison.Results: The average mandibular measurement difference between 3D models and MSCT scans is 0.26 mm more <2%. The final results of the comparison reveal high accuracy in 3D models compared to MSCT scan data.Conclusion: The 3D model could be considered as surgical guidance for maxillofacial reconstruction surgery since it yields highly accurate results.
SALIVARY ALPHA-AMYLASE AS A MEASURE OF ANXIETY BEFORE AND AFTER DENTAL TREATMENT FOR VISUALLY AND HEARING-IMPAIRED CHILDREN AND THEIR MOTHERS
Authors: Shofiyah Eka S , Sovaria Margaretha , Rizal Mochamad F , Budiardjo Sarworini B
Published: January 2018

Objective: Visual and hearing impairments are known to profoundly affect children’s psychological development, including their anxiety. However, strong emotional relationship with their mother found in these children may help them cope. Measuring salivary alpha-amylase (sAA) in saliva samples is widely used in clinical settings as a reliable, non-invasive biomarker of anxiety level.Methods: Our objective was to evaluate sAA levels in visually and hearing-impaired children and their mothers before and after dental treatment. This study included 60 children with visual and hearing impairments and their mothers. sAA level of both children and mothers was sampled while they were together in the waiting room before treatment. The children then underwent dental prophylaxis in a separate room, and their post-treatment sAA was measured immediately afterward. At that time, their mother’s post-treatment sAA was sampled in the waiting room. Data were analyzed using a Wilcoxon test.Results: sAA levels were found to differ significantly between pre- and post-dental treatment (p<0.05).Conclusion: This difference indicates that reducing maternal anxiety would be of great benefit in reducing anxiety in visually and hearing-impaired children. Practical implications: Appropriately managing anxiety in this group of children can be of great benefit to dentists in daily practice, helping them provide the care that these children need.
CORRELATION BETWEEN MASTICATORY PERFORMANCE AND QUALITY OF LIFE OF PATIENTS USING POSTERIOR DENTAL IMPLANTS
Authors: Rahayu Yayuk Supatmi , Dewi Ratna Sari , Odang Roselani , Masulili Chaidar
Published: January 2018

Introduction: Masticatory performance measurement to evaluate a patient’s satisfaction with dentures, including patients using posterior implant-supported single crowns, contributes to prosthetic treatment. Patient satisfaction rates can affect their quality of life (QoL). However, in Indonesia, these evaluations are rarely made.Objective: This study objective was to investigate the correlation of masticatory performance to oral health-related QoL in patients using posterior implant-supported single crowns.Methods: The study design was cross-sectional using twelve patients with posterior implant-supported single crowns. The study used sociodemographic data, a QoL questionnaire, and color-changeable chewing gum (Xylitol). A Spearman correlation was used to analyze the data. No significant correlation (p>0.05) was found between masticatory performance and oral health impact profile (OHIP) score.Results: This result study was expected because of the small number of subjects in the study. It is suggested that masticatory performance can be assessed objectively with color-changeable chewing gum and subjectively with a QoL questionnaire (OHIP 49-id).
DEVELOPMENT AND VALIDATION STABILITY INDICATING HPTLC METHOD FOR DETERMINATION OF VILDAGLIPTIN AND METFORMIN HYDROCHLORIDE IN THE PHARMACEUTICAL DOSAGE FORMS
Authors: Bendale Atul R. , Singh R. P. , Vidyasagar G.
Published: January 2018

Objective: A simple, precise, and accurate stability indicating high-performance thin layer chromatography method was developed and validated of vildagliptin (VIL) and metformin (MET) in pharmaceutical dosage forms.Methods: In the present study, system suitability test, stress study, alkali hydrolysis, acid hydrolysis, neutral hydrolysis, oxidative stress degradation, dry heat degradation, wet heat degradation, photodegradation study has been used. In this method, optimization by changing various parameters, such as organic solvent and the composition of the mobile phase, acid or base modifier used in the mobile phase; by varying one parameter and keeping all other conditions constant. 10 µl of the stock solution for MET (500 ng/band) and 2 µl of the stock solution for VIL (100 ng/band) were applied to TLC plates. The final solutions were applied on the HPTLC plates and these were developed as per the optimized densitometry conditions.Results: From the spectra, it was observed that MET and VIL exhibited good absorbance at about 217 nm. Both the drugs showed degradation with additional peaks at Rfvalues of 0.16 for MET and with Rfvalues 0.81 for VIL respectively. The method was validated for linearity, precision, accuracy, limit of detection, limit of quantification, ruggedness, specificity, and robustness. Good separation was achieved by using the mobile phase Hexane: Methanol: Acetonitrile: Glacial Acetic Acid (2:3.5:2.5:0.2 v/v/v/v) with retardation factor (Rf) values of 0.22±0.01 for MET and 0.73±0.02 for VIL.Conclusion: A validated HPTLC method was developed for the determination of metformin hydrochloride and vildagliptin. The method is simple, quick, and can be applied routinely for the analysis of these drugs from marketed dosage forms.
PHYSICO-MECHANICAL AND RELEASE PROPERTIES OF SUSTAINED RELEASE ARTESUNATE TABLETS IN HYDROXYPROPYL METHYLCELLULOSE MATRIX
Authors: Adedokun Musiliu , Onah Benjamin , Attama Anthony
Published: January 2018

Objective: This work was aimed at formulating artesunate tablets with hydroxypropyl methylcellulose (HPMC)-a hydrophilic polymer for the purpose of achieving a sustained release profile of the drug and evaluating their properties.Methods: The solubility profile of artesunate was determined in water, methanol, ethanol, ethanol/water mixtures (50/50, 40/60 v/v), simulated intestinal fluid (SIF) without enzymes (pH 7, 7.2 and 8), simulated gastric fluid (SGF) without enzymes (pH 1.2), 0.1N hydrochloric acid (HCI), 0.1N sodium hydroxide (NaOH), 0.1N acetic acid and phosphate buffer solution, PBS (pH 7, 7.2 and 8). Four batches of oral sustained release artesunate tablets intended for once-daily dosing were formulated with 10%, 20%, 25% and 30% w/w concentrations of HPMC using wet granulation method. Evaluation of granule properties was done by determining the angle of repose, flow rate, bulk density, tapped density, Carr’s index and Hausner’s quotient. The compressed tablets were also evaluated using official and non-official parameters. Absolute drug contents were determined in 0.1N NaOH, ethanol and methanol. In vitro release was studied in different media and release kinetics mechanism elucidated. In vivo studies were carried out using healthy Wistar rats.Results: Artesunate was observed to exhibit solubility at varying degrees depending on solvents or media employed as well as the pH of the media. All the granule batches have Hausner’s quotient value of approximately 1.2. The values for Carr’s index for all the batches ranged between 30 and 40. The angle of repose, Carr’s index and Hausner’s quotient values indicate good flow properties of the granules for all the batches. All the tablet batches conformed to official standard in terms of weight uniformity as no single tablet deviated beyond 5% from the average weight in each batch with no significant difference in the values (p>0.05). Values of hardness increased insignificantly from batches A to D (p>0.05). Friability values were very low and follows no specific pattern among the batches but the difference in the values was significant (p<0.05). Absolute drug content reduced while in vitro release times increased as hardness increased, indicating the probable progressive reduction in the tendency of the matrix to release the drug as the concentration of HPMC increased from batches A to D. n values obtained from analysis of release mechanism were above 0.89 for each batch.Conclusion: The release mechanism was shown to be complex and the release involved zero order, first order, and Higuchi model kinetics. The biological half-life of artesunate was shown to be 1.05 hr, and metabolites which bear resemblance to artesunate in absorbance seem to be encountered. In this work, HPMC matrix yielded high-quality tablets indicating its usefulness in sustained released product development.
Effectiveness of Neem (Azadirachta indica A. Juss) Oil against Decay Fungi
Authors:   Department of Forestry, Mizoram University, Aizawl, Mizoram–796004, Rawat Kanchan , Sahoo Uttam Kumar , Hegde Nagaraj ,   Department of Forestry, Mizoram University, Aizawl, Mizoram–796004, Kumar Awadhesh ,   Department of HAMP, Mizoram University, Aizawl, Mizoram–796004
Published: January 2018

The enormous use of metallic wood preservatives has caused destructive impact on environment as well as human health. Therefore realizing the urgency of switching to Environment friendly options such as natural oils are being tested for their antimicrobial properties. The present study aimed at investigating potential of Neem oil against the growth ofdecaying fungi. The ability of Neem oil to inhibit mycelia growth of Schizophyllum commune, Fusarium oxysporum, Fusarium proliferatum, Coniophora puteana and Alternaria alternata was tested at different concentrations of 0.25, 0.50, 0.75, 1.0, 2.0, 4.0, 6.0, 8.0 and 10%. Results of the study revealed Neem oil concentrations above 2% were significantly inhibitory to all the tested fungi.
Bioefficacy of Mikania micrantha H.B.K. against Water-Borne Bacterial Pathogens
Authors:   Department of Horticulture Aromatic and Medicinal Plants, Mizoram University, Aizawl–796004, Kumar Awadhesh , Hegde Nagaraj ,   Department of Forestry, Mizoram University, Aizawl, Mizoram–796009
Published: January 2018

The plant secondary metabolites play a very important role during the microbial attack. These metabolites (essential oils/ alkaloids/ glycosides/ tannins etc.) can be extracted from plant and many of these plant products can be used as a potential source for new antibacterial agents. In thepresent investigation, the extract extracted from dried leaves of Mikania micrantha by using Soxlet apparatus. The efficacy of extract was analyzed by broth microdilution method of CLSI against the E. coli, K. pneumoniae, P. vulgaris and S. dysenteriae in in-vitro condition. The result showed the minimum inhibitory concentration 0.317mg/ ml against E. coli; 0.429mg/ ml against K. pneumoniae; 1.16mg/ml against P. vulgaris and 0.437mg/ ml against S. dysenteriae; however, IC50 value was recorded as 0.162, 0.211, 0.670 and 0.214, respectively. The finding showed that the extract of M. micrantha having a good antibacterial activity. Its toxicity persisted heavy inoculums density, thermo stability and long shelf life.
Plant Community Structure of Tropical Semi-Evergreen Forest of Reiek in Mamit District of Mizoram
Authors:   Department of Environmental Science, Mizoram University, Lalzarzovi S.T. , Tluanga Lalnun
Published: January 2018

Ecological study of tropical semi-evergreen forest of Reiek in Mizoram was carried out to determine the stratification of the forest as well as to prepare life form spectrum of the plant communities. Mizoram is a part of Indo- Myanmar region which falls under one of the 35 biodiversity hotspots identified worldwide and therefore has a rich biodiversity. A detailed floristic survey was carried out. Plant species were collected, mounted in herbarium sheets and identified. Structural analysis was carried out and profile diagram was drawn. The forest was found to be composed of three layers in both the disturbed and undisturbed areas of the forest. The life form spectrum has been compared with Raunkiers normal spectrum to find out the phytoclimate of the region. The study area was found to have an abundance of phanerophytes indicating a phanerophytic climate
KARET ALAM EPOKSI SEBAGAI BAHAN BAKU PEMBUATAN KOMPONEN KARET PADA KATUP TABUNG DAN REGULATOR LPG
Authors: Handayani Hani , Faturrohman Muhammad Irfan , Kinasih Norma Arisanti , Falaah Asron Ferdian
Published: January 2018

Trend penurunan harga karet alam dalam 5 tahun terakhir mendorong diversifikasi produk berbasis karet alam, salah satunya adalah komponen karet pada katup tabung dan regulator LPG. Pembuatan komponen karet untuk katup dan regulator LPG selama ini masih menggunakan karet sintetis yang memiliki sifat polar. Karet sintetik NBR memiliki ketahanan yang baik terhadap LPG/n-pentana, sedangkan karet alam mudah mengembang dalam minyak. Epoksidasi ikatan rangkap molekul karet alam merupakan upaya untuk meningkatkan polaritasnya, sehingga ketahanannya terhadap minyak serta beberapa sifat fisiknya meningkat. Tujuan dari penelitian ini adalah meningkatkan konsumsi karet alam dengan cara substitusi karet sintetik (NBR) dengan karet alam epoksi. Lateks pekat diencerkan kemudian direaksikan dengan asam performat pada suhu 70 °C selama 5 jam kemudian dinetralkan, digumpalkan, digiling krep, dan dikeringkan. Karet alam epoksi yang diperoleh selanjutnya digunakan untuk formulasi komponen karet pada katup tabung dan regulator gas LPG dan diuji sesuai persyaratan di dalam SNI 7655:2010 tentang rubber seal. Hasil penelitian menunjukkan bahwa kompon berbasis karet alam epoksi memenuhi persyaratan SNI. Dengan demikian karet alam epoksi dapat digunakan sebagai bahan baku pembuatan komponen karet pada katup tabung dan regulator LPG.
Kollegialt følelsesarbejde på plejehjem og i daginstitutioner
Authors: Monrad Merete
Published: January 2018

Artiklen diskuterer kollegialt følelsesarbejde på baggrund af et studie af omsorgsarbejde i daginstitutioner for småbørn og på plejehjem. Baseret på 27 kvalitative interview med frontlinjemedarbejdere, belyser artiklen følelsesarbejdets kollektive karakter. Analysen er centreret omkring to spørgsmål: 1) På hvilken måde udgør kollegialt følelsesarbejde en ressource i omsorgsarbejdet? 2) Hvilken rolle spiller følelsesudtryk i distinktionsprocesser imellem kolleger? Artiklen viser, at de følelser, kolleger udtrykker, og de stemninger kolleger skaber, kan være en ressource i mestringen af arbejdet, og det foreslås, at denne ressource kan begrebsliggøres som en kollektiv emotionel kapital, som præger et medarbejderteam. Kollegialt følelsesarbejde spiller en rolle i distinktionsprocesser, og artiklen viser her, hvordan kolleger forholder sig til hinandens følelsesarbejde og til tider griber regulerende ind over for andres (mangelfulde) følelseshåndtering. Bestemte følelsesudtryk fremstår således implicit som forbundet med faglig status. Samspillet imellem arbejdsmiljøproblemer og den kollektive emotionelle kapital diskuteres, og der gives eksempler på, at medarbejdere oplever, at kollegiale diskussioner af arbejdsrelaterede frustrationer kan være nedbrydende for den kollektive emotionelle kapital. Det tydeliggør vigtigheden af at skabe et legitimt kollektivt rum for diskussioner af arbejdsrelaterede frustrationer, så de ikke fortrænges til individuelle og private fora af hensyn til den kollektive emotionelle kapital.

ENGELSK ABSTRACT:

Merete Monrad: Collegial Emotional Labour in Nursing Homes and Day Care Institutions

This article examines collegial emotional labour through a study of care work in day care institutions for children aged 0-6 years and in nursing homes. Based on 27 qualitative interviews with frontline workers, the article elucidates the collective nature of emotional labour in care work. The analysis is centered on two questions. First, in what way is collegial emotional labour a resource in care work, and second, what role do expressed emotions play in distinctions between colleagues? The article shows that colleagues’ emotions can be an important resource in coping with work, and suggests that this resource can be understood as collective emotional capital in the work team. Collegial emotional labour is related to processes of distinction, and the article analyzes how colleagues relate to each other’s emotional labour and how emotional expressions are implicitly related to professional status. The interplay between the working environment and collective emotional capital is discussed. Workers may experience that collegial discussions of work-related frustrations diminish collective emotional capital. The article raises the concern that work-related frustrations are displaced to individual and private conversations in order to preserve the collective emotional capital.

Keywords: care, emotional labour, colleagues, work environment, emotional capital.
The scribe of the Hilandar charter no. 139/141 and the Chrysobull of St Stephen palaeographic and philological analysis
Authors: Savic Viktor
Published: January 2018

Ever since it was discovered in the Topkap? Palace in Istanbul (1889), the
Chrysobull of St Stephen has not ceased to attract researchers? attention.
It is one of the most representative Serbian medieval charters, and the
first known example of a charter in the form of a book. The Chrysobull is a
rich resource for linguistic, historical, cultural and ethnic studies of the
Serbian medieval state in a wide area covered by the estates of the Banjska
monastery. A palaeographic and philological analysis has shown that the same
scribe who wrote out this stupendous monument of Serbian medieval law also
wrote King Milutin?s founding charter granted to the tower of Hrusija on the
sea coast, intended for the defence of the Hilandar monastery (Archbishop
Nikodim?s note of confirmation was added by the same hand at the bottom of
the scroll). Although rather extensive, this document is more than half as
extensive as the Chrysobull of St Stephen. Taking this into account and
keeping in mind the fact that it presents a lower degree of original content
(the tower was granted a rather small estate in Serbia for its own needs,
whereas the estate of the monastery to which it belonged was merely
enlarged), this document is, on the whole, a less abundant source of
information for research. Nevertheless, it additionally illuminates the
activity of a very prominent scribe from the beginning of the golden period
of Serbian medieval culture who tried himself in writing original documents
and original manuscript copies for the king. The Chrysobull reveals his
scribal diversity and contributes to a better understanding of the
activities of the royal chancery. The document may be used as a reliable
comparative material in linguistic research, as well as a control corpus to
check the previous knowledge, but also to make new conclusions. The
exceptional significance of the Chrysobull of St Stephen also increases the
significance of this Hilandar scroll.
Baletnaja skola Eleny Poljakovoj v kacestve casti gosudarstvennoj Aktersko-baletnoj skoly (1922-1927)
Authors: Sevic Milica
Published: January 2018

Elena Dmitrievna Poljakova, izvestnaja russkaja prima-balerina, pedagog,
rezisser i horeograf, javljaetsja vaznoj licnost'ju dlja razvitija baletnogo
iskusstva v Serbii. Kak cast' russkoj ?migracii Poljakova so sem'ej stala
zit' v Belgrade. Ona otkryla v Korolevstve Jugoslavii pervuju skolu baleta,
kotoraja porodila nekotorye nasi izvestnye hudozniki. Ee rol' javljaetsja
bolee znacitel'noj, kogda izvestno kakie tjazelye istoriceskie momenty
perezival serbskij i russkij narody, i znaja, kakim obrazom ona borolas' s
finansovymi trudnostjami i vozmoznost'ju zakrytija skoly. V rabote ispol'zovan
material iz Fonda Ministerstva obrazovanija Korolevstva Jugoslavii v Arhive
Jugoslavii. V ?tih dannyh javno vyhodjat na pervyj plan nekotorye iz kljucevyh
kacestv Poljakovoj, iz-za kotoryh ee uspeh i byl vozmozen, a ?to
nastojcivost', terpenie, celeustremlennost', volja i trud. V dopolnenie k
faktam o rabote Poljakovoj v oblasti baletnogo iskusstva, ?tot material
javljaetsja crezvycajno vaznym, poskol'ku on predostavljaet informaciju s
interesnymi podrobnostjami o sozdanii, razvitii i dejatel'nosti
Aktersko-baletnoj skoly.
Diabetes Center of Excellence Hypoglycemia Emergency Preparedness Project
Authors: Cobb Ellen C. , Watson Nina A. , Wardian Jana , Morrow Connie C. , Sauerwein Tom J.
Published: January 2018

IN BRIEF “Quality Improvement Success Stories” are published by the American Diabetes Association in collaboration with the American College of Physicians, Inc., and the National Diabetes Education Program. This series is intended to highlight best practices and strategies from programs and clinics that have successfully improved the quality of care for people with diabetes or related conditions. Each article in the series is reviewed and follows a standard format developed by the editors of Clinical Diabetes. The following article describes a successful effort to ensure that patients who are at risk for severe hypoglycemic events have a viable glucagon emergency plan in place.
Modest Decreases in Endogenous All-trans-Retinoic Acid Produced by a MouseRdh10Heterozygote Provoke Major Abnormalities in Adipogenesis and Lipid Metabolism
Authors: Yang Di , Vuckovic Marta G. , Smullin Carolyn P. , Kim Myeongcheol , Lo Christabel Pui-See , Devericks Emily , Yoo Hong Sik , Tintcheva Milena , Deng Yinghua , Napoli Joseph L.
Published: January 2018

Pharmacological dosing of all-trans-retinoic acid (atRA) controls adiposity in rodents by inhibiting adipogenesis and inducing fatty acid oxidation. Retinol dehydrogenases (Rdh) catalyze the first reaction that activates retinol into atRA. This study examined postnatal contributions of Rdh10 to atRA biosynthesis and physiological functions of endogenous atRA. Embryonic fibroblasts from Rdh10 heterozygote hypomorphs or with a total Rdh10 knockout exhibit decreased atRA biosynthesis and escalated adipogenesis. atRA or a retinoic acid receptor (RAR) pan-agonist reversed the phenotype. Eliminating one Rdh10 copy in vivo (Rdh10+/−) yielded a modest decrease (≤25%) in the atRA concentration of liver and adipose but increased adiposity in male and female mice fed a high-fat diet (HFD); increased liver steatosis, glucose intolerance, and insulin resistance in males fed an HFD; and activated bone marrow adipocyte formation in females, regardless of dietary fat. Chronic dosing with low-dose atRA corrected the metabolic defects. These data resolve physiological actions of endogenous atRA, reveal sex-specific effects of atRA in vivo, and establish the importance of Rdh10 to metabolic control by atRA. The consequences of a modest decrease in tissue atRA suggest that impaired retinol activation may contribute to diabesity, and low-dose atRA therapy may ameliorate adiposity and its sequelae of glucose intolerance and insulin resistance.
Stan Brakhage, näkyjen kuljettaja
Authors: Sihvonen Jukka
Published: January 2018

Nykyelokuvan tunnetuimpiin kuuluvalla amerikkalaisella elokuvantekijällä ja -ajattelijalla, Stan Brakhagella (syntymänimeltään Robert Sanders), oli kuollessaan 70-vuotiaana maaliskuussa vuonna 2003 noin viidenkymmenen työteliään vuoden ja lähes neljänsadan elokuvan tuotanto takanaan. Elokuvista lyhimmät ovat alle kymmenen sekunnin mittaisia, mutta pisimmät vastaavasti yltävät yli neljään tuntiin. Laajan ja moniaineksisen tuotannon pysyväksi tavoitteeksi muodostui jo varhain pyrkimys taltioida ihmissilmän rajatonta kykyä nähdä ilmeisen tuolle puolen.