bluuebunny/crossref_metadata_2025 huggingface dataset:
FROM OPPORTUNITY TO OCCASION: VICARIOUS LIABILITY IN THE HIGH COURT OF AUSTRALIA
Authors: Ryan Desmond
Published: April 2017

IN Prince Alfred College Incorporated v ADC [2016] HCA 37, the High Court of Australia (HCA) has once again considered the appropriate test for establishing vicarious liability of employers for the wrongful acts of their employees. The decision will be of interest to tort lawyers in the common-law world for at least four reasons. First, the Court looked afresh at the test for vicarious liability in the context of intentional wrongdoing and has accordingly clarified the confusion arising from its earlier decision in New South Wales v Lepore [2003] HCA 4; (2003) 212 C.L.R. 511. Secondly, the Court expressed very strong disagreement with the decision of the UK Supreme Court handed down just months earlier in Mohamud v WM Morrison Supermarkets plc [2016] UKSC 11; [2016] A.C. 677. The Court apparently regarded Mohamud as having in effect abandoned the Lister qualification that mere opportunity was not enough to satisfy the close connection test (Lister v Hesley Hall Ltd. [2001] UKHL 22; [2002] 1 A.C. 215). Thirdly, the Court appears to have interpreted the relevant English authorities as espousing a Caparo-like criterion of fairness and justice as a separate stage of the close connection test (Caparo Industries plc v Dickman [1990] 2 A.C. 605). That interpretation is questionable. Finally, the Court has articulated a new test in Australian law for vicarious liability reasoning based on whether the employment provided the “occasion” for the wrongdoing to be committed. This prompts a reflection on the difference between “occasion” and “opportunity”, and how this new test is to be applied in practice.
AUTONOMOUS CHARACTERISATION UNDER THE BRUSSELS I REGULATION RECAST
Authors: Rogerson Pippa
Published: April 2017

IN Arcadia Petroleum Ltd. v Bosworth [2016] EWCA Civ 818, three companies in the Arcadia Petroleum Group sued their de facto CEO and CFO and others in England for siphoning off money for their own benefit. One of the companies was incorporated in England, the others in Singapore and Switzerland. The companies claimed for unlawful means conspiracy, breach of fiduciary duty, dishonest assistance and knowing receipt. Could these claims all be litigated in England under the Lugano Convention, which allocates jurisdiction to determine disputes among the members of EFTA (the provisions at issue are identical to those of the Brussels I Regulation (No 44/2001) applicable in the EU)? The conclusion depended on whether the claims related to a contract of employment, or were contractual or were tortious. Each characterisation led to a different court with jurisdiction. The Court of Appeal held that mostly they could be litigated in England; only those for breach of fiduciary duty arising during the period of the directors' employment could not.
Contrasting subduction–exhumation paths in the blueschists of the Anarak Metamorphic Complex (Central Iran)
Authors: ZANCHETTA S. , MALASPINA N. , ZANCHI A. , BENCIOLINI L. , MARTIN S. , JAVADI H.R. , KOUHPEYMA M.
Published: April 2017

The Anarak Metamorphic Complex, localized in Central Iran, is a fossil accretionary wedge composed of several tectonometamorphic units. Some of these, the Chah Gorbeh, the Morghab and the Ophiolitic complexes, contain mafic rocks that have been metamorphosed at high-pressure–low-temperature conditions. Such units have been stacked together and later refolded during the final stages of exhumation. Structural analysis at the mesoscale recognized at least three deformation events. Microstructural analyses, mineral chemistry and thermodynamic modelling reveal that the mafic schists followed contrasting P–T paths during their tectonometamorphic evolutions. In the schists of the Chah Gorbeh and Ophiolitic complexes an early greenschist-facies stage was later overprinted by blueschist-facies phase assemblages with suggested peak conditions of 390–440°C at 0.6–0.9 GPa for the meta-basalt within the Ophiolitic Complex and 320–380°C at 0.6–0.9 GPa for the blueschists of the Chah Gorbeh Complex. P–T conditions at metamorphic peak were 410–450°C at 0.78–0.9 GPa for the Morghab blueschists, but they are reached before a greenschist-facies re-equilibration. Compositional zoning of amphiboles and epidotes of this greenschist-facies stage suggests a renewed pressure increase at the end of this metamorphic stage. Based on these data we reconstructed a clockwise P–T path for the Morghab mafic schists and a counter-clockwise path for the Chah Gorbeh blueschists and ophiolitic meta-basalts. Such contrasting metamorphic evolutions of tectonic units that were later accreted to the same wedge are indicative of the complex tectonic dynamics that occur within accretionary–subduction complexes.
LOCATING COLONIZATION AT THE JACOBEAN INNS OF COURT
Authors: WORKING LAUREN
Published: April 2017

Beyond charters, printed propaganda, and cosmographies, aspiring statesmen in Jacobean England engaged with Native Americans in commonplace books, poetry, court masques, and political debate. Rather than representing a remote ‘other’, this article contends that barristers and students of the law were fascinated by the perceived savagery of indigenous peoples because it allowed them to explore, interrogate, and define their own civility. The result was a cross-over between developing English articulations of their own behaviour and political responsibilities, and a rising enthusiasm for colonizing America. With their Whitehall masques and passionate pleas in parliament on behalf of Virginia and Virginian tobacco, members of the Inns engaged in a subversive wit culture that reconciled the exotic with the language of duty and good conduct, and helped turn colonization into a recognizable – and, for the first time, fashionable – element of early seventeenth-century political culture. By considering written discourse alongside tobacco smoking and court masques, this article contends that a broad approach to the socio-cultural world of Jacobean politics reveals some ways through which gentlemen consciously projected their civil state as one that might be strengthened, rather than weakened, by turning to America as a viable theatre for political involvement.
NEGOTIATING FREE WILL: HYPNOSIS AND CRIME IN EARLY TWENTIETH-CENTURY GERMANY
Authors: KAUDERS ANTHONY D.
Published: April 2017

The history of free will has yet to be written. With few exceptions, the literature on the subject is dominated by legal and philosophical works, most of which recount the ideas of prominent thinkers or discuss hypothetical questions far removed from specific historical contexts. The following article seeks to redress the balance by tracing the debate on hypnosis in Germany from 1894 to 1936. Examining responses to hypnosis is tantamount to recording common understandings of autonomy and heteronomy, self-control and mind control, free will and automaticity. More specifically, it is possible to identify distinct philosophical positions related to the question as to whether hypnosis could surmount free will or not. The article demonstrates that the discourse often centred on the perceived struggle, located within a particular ‘personality’, between an individual's ‘character’ or ‘soul’ and the infiltration by a foreign or hostile force. While one group (compatibilists) emphasized the resilience of the ‘moral inhibitions’, another group (determinists) doubted that these were sufficient to withstand hypnosis.
The (In)compatibility of Peace and Justice? The International Criminal Court and Civil Conflict Termination
Authors: Prorok Alyssa K.
Published: April 2017

Does the International Criminal Court's (ICC) pursuit of justice facilitate peace or prolong conflict? This paper addresses the “peace versus justice” debate by examining the ICC's impact on civil conflict termination. Active ICC involvement in a conflict increases the threat of punishment for rebel and state leaders, which, under certain conditions, generates incentives for these leaders to continue the conflict as a way to avoid capture, transfer to the Hague, and prosecution. The impact of ICC involvement is conditional upon the threat of domestic punishment that leaders face; as the risk of domestic punishment increases, the conflict-prolonging effects of ICC involvement diminish. I test these theoretical expectations on a data set of all civil conflict dyads from 2002 to 2013. Findings support the hypothesized relationship. Even after addressing potential selection and endogeneity concerns, I find that active involvement by the ICC significantly decreases the likelihood of conflict termination when the threat of domestic punishment is relatively low.
MATERNAL ACTIVITY DURING PREGNANCY AND SEXUALLY DIMORPHIC TRAITS IN OFFSPRING
Authors: Ellis Lee , Eisenman Russell , Hoskin Anthony
Published: April 2017

Studies have found positive correlations between prenatal exposure to testosterone and masculinization of offspring traits, particularly among females. The present study sought to determine if physical or sexual activity by the mother during pregnancy was related to masculinized/defeminized offspring traits in adulthood. Data were obtained from a large sample of North American college students (offspring) and their mothers. Information about maternal activity levels during pregnancy were reported retrospectively by each mother. The offspring provided self-ratings of various sexually dimorphic traits. Several significant correlations were found. By and large, as maternal physical activity increased, feminine mannerisms decreased and masculine mannerisms increased in the offspring, particularly for females. Maternal physical activity was also associated with increased upper- and lower-body strength and especially with adult height among offspring. Sexual activity by the mother was only associated with upper-body strength and adult height, particularly of the female offspring. Several sexually dimorphic physical traits in offspring are associated with maternal activity levels during pregnancy. Prenatal testosterone is almost certainly involved. The associations could either reflect genetic influences (given that prenatal testosterone is highly heritable) or an effect of maternal testosterone being transferred to the developing fetus. More research is needed to assess the relative merit of these two possibilities.
MARRIAGE GAP IN CHRISTIANS AND MUSLIMS
Authors: Fieder Martin , Huber Susanne , Pichl Elmar , Wallner Bernard , Seidler Horst
Published: April 2017

For modern Western societies with a regime of monogamy, it has recently been demonstrated that the socioeconomic status of men is positively associated with being or having been married. This study aims to compare marriage patterns (if a person has been married at least once) for cultures with a tradition of monogamy and polygyny. As no worldwide data on polygyny exist, religion was used as a proxy for monogamy (Christians) vs polygyny (Muslims). The analyses were based on 2000–2011 census data from 39 countries worldwide for 52,339,594 men and women, controlling for sex, sex ratio, age, education, migration within the last 5 years and employment. Overall, a higher proportion of Muslims were married compared with Christians, but the difference in the fraction of married men compared with married women at a certain age (the ‘marriage gap’) was much more pronounced in Muslims than in Christians, i.e. compared with Christians, a substantially higher proportion of Muslim women than men were married up to the age of approximately 31 years. As expected for a tradition of polygyny, the results indicate that the socioeconomic threshold for entering marriage is higher for Muslim than Christian men, and Muslim women in particular face a negative effect of socioeconomic status on the probability of ever being married. The large ‘marriage gap’ at a certain age in Muslim societies leads to high numbers of married women and unmarried young men, and may put such polygenic societies under pressure.
The role of race in thyroid cancer: systematic review
Authors: Keane E , Francis E C , Catháin É Ó , Rowley H
Published: April 2017

Background:

The incidence of thyroid cancer is increasing. There is conflicting evidence as to why. However, studies suggest that it is not an apparent increase resulting from enhanced diagnostic practices, but a true increase with more affected patients. This study aimed to assess racial variation in thyroid cancer.

Method:

A narrative systematic review of the literature was conducted.

Results:

Eight retrospective cohort studies were identified, comprising 611 777 adult patients. Variations exist between racial groups, which are also dependent on gender; white patients have a slightly higher male population when compared to their counterparts. Black and white patients have a higher proportion of follicular cancer. Hispanics were younger at the age of diagnosis. Outcomes are greatly affected by socioeconomic status.

Conclusion:

This study identified many gaps in the way that these types of data are presented. A more concise manner of reporting, with individual-level risk factors, is recommended.
Developing Sustainability in the Brazilian Amazon: Twenty Years of History in the Mamirauá and Amanã Reserves
Authors: LIMA DEBORAH DE MAGALHÃES , PERALTA NELISSA
Published: April 2017

This paper discusses the ability of Sustainable Development Reserves toembed(in Karl Polanyi's sense) the economy into the environment through the development of protocols for the sustainable management of natural resources. Based on two decades of work in the Mamirauá and Amanã Sustainable Development Reserves, we question whether the results are good, fair and viable by comparing two alternatives: unregulated markets and fully protected reserves. We evaluate the interest in sustainability; discuss who benefits and who pays for it; reflect on its potential to reduce inequalities; and discuss its economic and political viability.
Familial transient financial difficulties during infancy and long-term developmental concerns
Authors: Ramanathan S. , Balasubramanian N. , Faraone S. V.
Published: April 2017

Background

Socioeconomic difficulties affect the cognitive and emotional development of children. However, the focus of prior studies has largely been on poverty and material hardship. This study expands on the existing literature by examining the impact of familial transient financial difficulties during infancy on long-term cognitive and behavioral outcomes.

Methods

The National Longitudinal Surveys of Youth (79) were used to assess the association between a transient drop in family income by 50% or more (called transient income decline or TID) during the first 3 years of life and later-life Peabody Individual Achievement Math and Reading scores and behavior problem index (BPI) scores (N= 8272–17 348; median assessment age = 9 years). A subsample of matched siblings (N= 2049–4238) was examined to tease out maternal and intra-familial effects.

Results

Exposure to TID predicted increased total and externalizing BPI scores (std. coefficients of 0.10 and 0.09, respectively,p< 0.01) in the overall sample. Among matched siblings, exposure to TID predicted increased total, externalizing, and internalizing BPI scores (std. coefficients of 0.27, 0.25, and 0.23, respectively,p< 0.01).

Conclusion

Familial transient financial difficulties can have long-lasting behavioral effects for infants. The study identifies an early risk factor and at-risk children, thus providing insight into developing early intervention measures for infants to avoid long-term behavioral problems.
Social needs of older people: a systematic literature review
Authors: BRUGGENCATE TINA TEN , LUIJKX KATRIEN G. , STURM JANIENKE
Published: April 2017

Social needs are important basic human needs. When social needs are not satisfied, this can lead to mental and physical health problems. With a growing population of older adults and the need for them to stay healthy and community-dwelling, satisfying social needs is important. The aim of this review is to give more insight into the social needs of older people and subsequently into the characteristics of effective interventions for satisfying older people's social needs. A systematic review of the existing literature on quantitative, qualitative and mixed empirical studies on the social needs of older people was conducted. The themes that emerged were diversity, proximity, meaning of the relationship and reciprocity. These themes offered several intervention implications. Participation in hobbies and in volunteer work and being connected were among the main findings. The social needs of older people are diverse. They focus on both the intimate and the peripheral members of their networks. When satisfying social needs, reciprocity is important. The feeling of connectedness to others and to a community or neighbourhood contributes to wellbeing as well as a feeling of independence. Staying active by doing volunteer work or participating in (leisure) social activities satisfies social needs. Therefore, interventions should focus especially on the connectedness, participation and independence of the older adult.
Constrained model predictive control for mobile robotic manipulators
Authors: Buizza Avanzini Giovanni , Zanchettin Andrea Maria , Rocco Paolo
Published: April 2017

This paper discusses the application of a constraint-based model predictive control (MPC) to mobile manipulation tracking problems. The problem has been formulated so as to guarantee offset-free tracking of piecewise constant references, with convergence and recursive feasibility guarantees. Since MPC inputs are recomputed at every control iteration, it is possible to deal with dynamic and unknown scenarios. A number of motion constraints can also be easily included: Acceleration, velocity and position constraints have been enforced, together with collision avoidance constraints for the mobile base and the arm and field-of-view constraints. Such constraints have been extended over the prediction horizon maintaining a linear-quadratic formulation of the problem. Navigation performance has been improved by devising an online algorithm that includes an additional goal to the problem, derived from the classical vortex field approach. Experimental validation shows the applicability of the proposed approach.
Collision avoidance method for multi-operator multi-robot teleoperation system
Authors: García S. E. , Slawiñski E. , Mut V. , Penizzotto F.
Published: April 2017

This paper proposes a collision avoidance method for the teleoperation of multiple non-holonomic mobile robots from multiple users. Each human operator drives a mobile robot, where each one performs an independent task in a common workspace. To avoid collisions, the proposed method only acts on the speed of the mobile robots; therefore, the human operator can freely drive the robot over the path he chooses to. The developed analysis allows us to assure that a solution is always achieved. Finally, the results of the experiments are shown, in order to test the performance of the proposed control scheme.
Assessing visitors’ preferences for ecosystem features in a desert biodiversity hotspot
Authors: CERDA CLAUDIA , FUENTES JUAN PABLO , DE LA MAZA CARMEN LUZ , LOUIT CARLA , ARAOS ANA
Published: April 2017

We estimated visitors’ willingness to pay (WTP) for a variety of environmental attributes in a protected area of the Atacama Desert, a biodiversity hotspot in northern Chile. By using a choice experiment, WTP was estimated for the protection of the following attributes: animals (mammals, amphibians, reptiles and birds), pollinating insects, plants (cacti and woody shrubs), soil quality and pristine landscapes. Visitors placed economic value on all of the attributes. The marginal mean WTP/visitor for the single levels of variation in the attributes ranged from US$4 (for supporting research on foxes) to US$26 (for maintaining soil quality) per visitor per month. These results can contribute to deciding which attributes are likely to be successful at raising funds for conservation. Our approach may be relevant to protected areas of the world with high conservation values, little funding and a lack of large, charismatic species.
Transitional Justice + Cyberjustice = Justice2?
Authors: KASTNER PHILIPP
Published: April 2017

The increased use of information and communication technologies arguably represents important opportunities for the field of transitional justice, notably with respect to the optimization of existing mechanisms and the development of new ones. This article focuses on state-based and typically very formal mechanisms, namely international, internationalized and national criminal tribunals as well as truth and reconciliation commissions. These institutions often apply and engage with international law and operate with the involvement or under the close scrutiny of the international community. Moreover, they can be expected to be the first ones to embrace insights from the field of cyberjustice to a significant extent.

Enhancing access to and participation in such mechanisms, rendering them more cost-efficient and facilitating information-sharing would correspond to generally accepted norms relating to both international human rights and justice. However, cyberjustice initiatives may also entrench an already common ‘toolkit approach’ in the field of transitional justice. This article builds on recent critiques of the dominant legalistic and normatively driven transitional justice paradigm and argues that transitional justice + cyberjustice hence risks furthering a technocratic top-down approach that unduly limits creative solutions. By adopting a critical legal-pluralistic approach that conceives individuals as law-creative actors and that is cognizant of the close relationship between means and ends, the article imagines ways of benefiting from the promises of transitional justice + cyberjustice.
Externalizing and internalizing pathways to Mexican American adolescents’ risk taking
Authors: Gonzales Nancy A. , Liu Yu , Jensen Michaeline , Tein Jenn Yun , White Rebecca M. B. , Deardorff Julianna
Published: April 2017

This study used four waves of data from a longitudinal study of 749 Mexican origin youths to test a developmental cascades model linking contextual adversity in the family and peer domains in late childhood to a sequence of unfolding processes hypothesized to predict problem substance use and risky sexual activity (greater number of sex partners) in late adolescence. Externalizing and internalizing problems were tested as divergent pathways, with youth-reported and mother-reported symptoms examined in separate models. Youth gender, nativity, and cultural orientation were tested as moderators. Family risk, peer social rejection, and their interaction were prospectively related to externalizing symptoms and deviant peer involvement, although family risk showed stronger effects on parent-reported externalizing and peer social rejection showed stronger effects on youth-reported externalizing. Externalizing symptoms and deviant peers were related, in turn, to risk taking in late adolescence, including problem alcohol–substance use and number of sexual partners. Peer social rejection predicted youth-reported internalizing symptoms, and internalizing was related, in turn, to problem alcohol and substance use in late adolescence. Tests of moderation showed some of these developmental cascades were stronger for adolescents who were female, less oriented to mainstream cultural values, and more oriented to Mexican American cultural values.
Methodological Challenges in Studies Comparing Prehospital Advanced Life Support with Basic Life Support
Authors: Li Timmy , Jones Courtney M. C. , Shah Manish N. , Cushman Jeremy T. , Jusko Todd A.
Published: April 2017

Determining the most appropriate level of care for patients in the prehospital setting during medical emergencies is essential. A large body of literature suggests that, compared with Basic Life Support (BLS) care, Advanced Life Support (ALS) care is not associated with increased patient survival or decreased mortality. The purpose of this special report is to synthesize the literature to identify common study design and analytic challenges in research studies that examine the effect of ALS, compared to BLS, on patient outcomes. The challenges discussed in this report include: (1) choice of outcome measure; (2) logistic regression modeling of common outcomes; (3) baseline differences between study groups (confounding); (4) inappropriate statistical adjustment; and (5) inclusion of patients who are no longer at risk for the outcome. These challenges may affect the results of studies, and thus, conclusions of studies regarding the effect of level of prehospital care on patient outcomes should require cautious interpretation. Specific alternatives for avoiding these challenges are presented.

LiT,JonesCMC,ShahMN,CushmanJT,JuskoTA.Methodological challenges in studies comparing prehospital Advanced Life Support with Basic Life Support.Prehosp Disaster Med.2017;32(4):444–450.
Mild Cognitive Impairment Subtypes in a Cohort of Elderly Essential Tremor Cases
Authors: Collins Kathleen , Rohl Brittany , Morgan Sarah , Huey Edward D. , Louis Elan D. , Cosentino Stephanie
Published: April 2017

Objectives

Individuals with essential tremor (ET) exhibit a range of cognitive deficits generally conceptualized as “dysexecutive” or “fronto-subcortical,” and thought to reflect disrupted cortico-cerebellar networks. In light of emerging evidence that ET increases risk for Alzheimer’s disease (AD), it is critical to more closely examine the nature of specific cognitive deficits in ET, with particular attention to amnestic deficits that may signal early AD.

Methods

We performed a cross-sectional analysis of baseline data from 128 ET cases (age 80.4±9.5 years) enrolled in a longitudinal, clinical-pathological study. Cases underwent a comprehensive battery of motor-free neuropsychological tests and a functional assessment to inform clinical diagnoses of normal cognition (ET-NC), mild cognitive impairment (MCI) (ET-MCI), or dementia (ET-D). ET-MCI was subdivided into subtypes including: amnestic single-domain (a-MCI), amnestic multi-domain (a-MCI+), non-amnestic single-domain (na-MCI), or non-amnestic multi-domain (na-MCI+).

Results

Ninety-one (71.1%) cases were ET-NC, 24 (18.8%) were ET-MCI, and 13 (10.2%) were ET-D. Within MCI, the a-MCI+ subtype was the most common (13/24; 54.2%) followed by a-MCI (4/24; 16.7%), na-MCI+ (4/24; 16.7%), and na-MCI (3/24; 12.5%). Cases with amnestic MCI demonstrated lower recognition memoryZ-scores (−2.4±1.7) than non-amnestic groups (−0.9±1.2) (p=.042).

Conclusions

Amnestic MCI, defined by impaired memory recall but associated with lower memory storage scores, was the most frequent MCI subtype in our study. Such impairment has not been explicitly discussed in the context of ET and may be an early hallmark of AD. Results have implications for the prognosis of specific cognitive deficits in ET. (JINS, 2017,23, 390–399)
The livelihood impacts of the Equitable Payments for Watershed Services (EPWS) Program in Morogoro, Tanzania
Authors: Kwayu Emmanuel J. , Paavola Jouni , Sallu Susannah M.
Published: April 2017

Research on PES programs in agro-ecosystems is recent and limited in developing countries. The authors use a multi-method, quasi-experimental impact evaluation approach to examine direct and indirect livelihood impacts of the Equitable Payments for Watershed Services (EPWS) program piloted in the Morogoro region in Tanzania. The evaluation is based on a survey of 116 program participants and 117 non-participants, 32 semi-structured interviews and 16 focus group discussions to complement the survey data. They find that, while the EPWS program incentives resulted in direct benefits, indirect benefits such as increased crop yields, higher land values, new employment opportunities, more knowledgeable farmers, improved leadership skills as well as increased trust, expanded internal and external networks and strengthened institutions were more important. The results clearly indicate the potential of PES schemes to generate win-win outcomes in agro-ecosystems, but they also call for attention to equity in the design of PES programs implemented on agro-ecosystems.
Segmentation and Quantitative Analysis of Apoptosis of Chinese Hamster Ovary Cells from Fluorescence Microscopy Images
Authors: Du Yuncheng , Budman Hector M. , Duever Thomas A.
Published: April 2017

Accurate and fast quantitative analysis of living cells from fluorescence microscopy images is useful for evaluating experimental outcomes and cell culture protocols. An algorithm is developed in this work to automatically segment and distinguish apoptotic cells from normal cells. The algorithm involves three steps consisting of two segmentation steps and a classification step. The segmentation steps are: (i) a coarsesegmentation, combining a range filter with a marching square method, is used as a prefiltering step to provide the approximate positions of cells within a two-dimensional matrix used to store cells’ images and the count of the number of cells for a given image; and (ii) a fine segmentation step using the Active Contours Without Edges method is applied to the boundaries of cells identified in the coarse segmentation step. Although this basic two-step approach provides accurate edges when the cells in a given image are sparsely distributed, the occurrence of clusters of cells in high cell density samples requires further processing. Hence, a novel algorithm for clusters is developed to identify the edges of cells within clusters and to approximate their morphological features. Based on the segmentation results, a support vector machine classifier that uses three morphological features: the mean value of pixel intensities in the cellular regions, the variance of pixel intensities in the vicinity of cell boundaries, and the lengths of the boundaries, is developed for distinguishing apoptotic cells from normal cells. The algorithm is shown to be efficient in terms of computational time, quantitative analysis, and differentiation accuracy, as compared with the use of the active contours method without the proposed preliminary coarse segmentation step.
Contracting and gender equity in Tanzania: using a value chain approach to understand the role of gender in organic spice certification
Authors: Bullock Renee , Gyau Amos , Mithoefer Dagmar , Swisher Marilyn
Published: April 2017

Value chain development (VCD) initiatives within the horticultural and organic sectors in Africa are promising strategies to improve smallholder welfare. Contracting institutional arrangements are a common feature of VCD initiatives and are increasing in number in sub-Saharan Africa as a way to source organic products from smallholder producers. The objective of this study is to better understand men and women's participation in spice producing households that sell under contract and in conventional market chains in the East Usambaras, Tanzania. We draw on New Institutional Economics, political economy and the value chain analysis framework to assess the potential role of contracting to promote gender equity among smallholder organic horticultural producers. We describe intra-household decision making over resources and marketing, access to benefits of contracting, and labor distribution between men and women in contracting and non-contracting households. We then extend the gender analysis to evaluate the role of gender in contracting and conventional value chains operating within the community and district. Using a cross-sectional research design and data collected through 13 focus group discussions, 54 personal interviews and 156 household questionnaires, we show that contracting reduces transaction costs in the chain compared with the conventional trade. However, norms in the wider political economic context give rise to gendered patterns of participation in both household and chain activities in contracting and non-contracting households. Our findings suggest that contracting does not provide significant opportunities for women in married households to participate and benefit based on limited participation in decision-making and access to trainings. Divorced women and widows gain access to contract employment opportunities to earn income. This study highlights the importance of understanding gender relations in the household and community to guide the development of gender equitable VCD initiatives and contracting approaches.
Fractional Fourier transform-based chirp radars for countering self-protection frequency-shifting jammers
Authors: Hanbali Samer Baher Safa , Kastantin Radwan
Published: April 2017

Self-protection deceptive jammers create at the radar receiver output multiple-false targets that are impossible to isolate in both time and frequency domains. In this paper, we introduce a novel technique based on fractional Fourier transform (FrFT) to discriminate between the true target echo and those false targets in the case of frequency-shifting jammers. In fact, we exploit the capability of the FrFT to resolve, in a matched manner, spectra that are overlapping in time and frequency. This is a property that cannot be achieved using a standard matched filter. The theoretical analysis of this technique is presented and its effectiveness is verified by simulation.
The Singaporean public beliefs about the causes of mental illness: results from a multi-ethnic population-based study
Authors: Pang S. , Subramaniam M. , Lee S. P. , Lau Y. W. , Abdin E. , Chua B. Y. , Picco L. , Vaingankar J. A. , Chong S. A.
Published: April 2017

Aims.

To identify the common causal beliefs of mental illness in a multi-ethnic Southeast Asian community and describe the sociodemographic associations to said beliefs. The factor structure to the causal beliefs scale is explored. The causal beliefs relating to five different mental illnesses (alcohol abuse, depression, obsessive-compulsive disorder (OCD), dementia and schizophrenia) and desire for social distance are also investigated.

Methods.

Data from 3006 participants from a nationwide vignette-based study on mental health literacy were analysed using factor analysis and multiple logistic regression to address the aims. Participants answered questions related to sociodemographic information, causal beliefs of mental illness and their desire for social distance towards those with mental illness.

Results.

Physical causes, psychosocial causes and personality causes were endorsed by the sample. Sociodemographic differences including ethnic, gender and age differences in causal beliefs were found in the sample. Differences in causal beliefs were shown across different mental illness vignettes though psychosocial causes was the most highly attributed cause across vignettes (endorsed by 97.9% of respondents), followed by personality causes (83.5%) and last, physical causes (37%). Physical causes were more likely to be endorsed for OCD, depression and schizophrenia. Psychosocial causes were less often endorsed for OCD. Personality causes were less endorsed for dementia but more associated with depression.

Conclusions.

The factor structure of the causal beliefs scale is not entirely the same as that found in previous research. Further research on the causal beliefs endorsed by Southeast Asian communities should be conducted to investigate other potential causes such as biogenetic factors and spiritual/supernatural causes. Mental health awareness campaigns should address causes of mental illness as a topic. Lay beliefs in the different causes must be acknowledged and it would be beneficial for the public to be informed of the causes of some of the most common mental illnesses in order to encourage help-seeking and treatment compliance.
Relationship between Leadership among Peers and Burnout in Sports Teams
Authors: Torrado Julio , Arce Constantino , Vales-Vázquez Ángel , Areces Alberto , Iglesias Gabriel , Valle Iván , Patiño Gabriel
Published: April 2017

This study has been conducted with the aim of ascertaining the relationship between peer leaders in sport teams and the levels of burnout experienced by their team-mates. A total of 219 Spanish athletes involved in football and basketball participated in the study. To measure leadership among peers, we employed the Sports Peer Leadership Scale, which comprises 24 items, grouped into 6 primary factors: empathy, influence on decision making, sports values, social support, training orientation and competition orientation. And to measure burnout, we employed the Athlete Burnout Questionnaire, which comprises 15 items which are indicators of physical and emotional exhaustion, devaluation and reduced sense of accomplishment among athletes. The results led to the conclusion that there is a statistically significant negative relationship between perceived leadership capacity and the levels of burnout experience by a team. The greater the level of leadership capacity perceived, the lower the levels of burnout will be. A multiple regression analysis with total burnout as dependent variable and social and task orientations of the leader as predictors showed standardized regression coefficients of –.241 (p = .010) and –.076 (p = .413), respectively for social and task orientation, being the effect size equal to .089.
Sumatran Fleabane (Conyza sumatrensis) Control in No-Tillage Soybean with Diclosulam Plus Halauxifen-Methyl
Authors: Braz Guilherme B. P. , Oliveira Rubem S. , Zobiole Luiz Henrique S. , Rubin Rogério S. , Voglewede Christopher , Constantin Jamil , Takano Hudson K.
Published: April 2017

Due to the limited availability of selective herbicides to control Sumatran fleabane after soybean emergence, it is essential to develop new options that provide effective control prior to planting. A new herbicide formulation containing diclosulam+halauxifen-methyl was evaluated for effectiveness at two Sumatran fleabane plant heights (5 to 10 cm, and 10 to 50 cm) and for soybean selectivity when applied at 7 or 3 d before planting. Combined results from the two sites showed that diclosulam+halauxifen, applied either alone or in a tank mixture with glyphosate, and the tank mixture of diclosulam+2,4-D amine+glyphosate are effective at all rates tested to control Sumatran fleabane in preplant applications. Crop response was observed with applications 7 days before planting at only one of the sites. A rate-dependent crop response was observed for pre-plant applications performed 3 days before soybean planting. However, crop yield was not significantly affected for either timing across all rates. All rates tested of diclosulam+halauxifen in this study were considered safe to soybean.
Learning through ferroelectric domain dynamics in solid-state synapses
Authors: Boyn Sören , Grollier Julie , Lecerf Gwendal , Xu Bin , Locatelli Nicolas , Fusil Stéphane , Girod Stéphanie , Carrétéro Cécile , Garcia Karin , Xavier Stéphane , Tomas Jean , Bellaiche Laurent , Bibes Manuel , Barthélémy Agnès , Saïghi Sylvain , Garcia Vincent
Published: April 2017

In the brain, learning is achieved through the ability of synapses to reconfigure the strength by which they connect neurons (synaptic plasticity). In promising solid-state synapses called memristors, conductance can be finely tuned by voltage pulses and set to evolve according to a biological learning rule called spike-timing-dependent plasticity (STDP). Future neuromorphic architectures will comprise billions of such nanosynapses, which require a clear understanding of the physical mechanisms responsible for plasticity. Here we report on synapses based on ferroelectric tunnel junctions and show that STDP can be harnessed from inhomogeneous polarization switching. Through combined scanning probe imaging, electrical transport and atomic-scale molecular dynamics, we demonstrate that conductance variations can be modelled by the nucleation-dominated reversal of domains. Based on this physical model, our simulations show that arrays of ferroelectric nanosynapses can autonomously learn to recognize patterns in a predictable way, opening the path towards unsupervised learning in spiking neural networks.
Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses
Authors: Dallari S. , Macal M. , Loureiro M. E. , Jo Y. , Swanson L. , Hesser C. , Ghosh P. , Zuniga E. I.
Published: April 2017

Plasmacytoid dendritic cells (pDC) are type I interferon-producing cells with critical functions in a number of human illnesses; however, their molecular regulation is incompletely understood. Here we show the role of Src family kinases (SFK) in mouse and human pDCs. pDCs express Fyn and Lyn and their activating residues are phosphorylated both before and after Toll-like receptor (TLR) stimulation. Fyn or Lyn genetic ablation as well as treatment with SFK inhibitors ablate pDC (but not conventional DC) responses bothin vitroandin vivo. Inhibition of SFK activity not only alters TLR-ligand localization and inhibits downstream signalling events, but, independent ofex-vivoTLR stimulation, also affects constitutive phosphorylation of BCAP, an adaptor protein bridging PI3K and TLR pathways. Our data identify Fyn and Lyn as important factors that promote pDC responses, describe the mechanisms involved and highlight a tonic SFK-mediated signalling that precedes pathogen encounter, raising the possibility that small molecules targeting SFKs could modulate pDC responses in human diseases.
Enzyme catalysed Pictet-Spengler formation of chiral 1,1’-disubstituted- and spiro-tetrahydroisoquinolines
Authors: Lichman Benjamin R. , Zhao Jianxiong , Hailes Helen C. , Ward John M.
Published: April 2017

The Pictet–Spengler reaction (PSR) involves the condensation and ring closure between a β-arylethylamine and a carbonyl compound. The combination of dopamine and ketones in a PSR leads to the formation of 1,1′-disubstituted tetrahydroisoquinolines (THIQs), structures that are challenging to synthesize and yet are present in a number of bioactive natural products and synthetic pharmaceuticals. Here we have discovered that norcoclaurine synthase fromThalictrum flavum(TfNCS) can catalyse the PSR between dopamine and unactivated ketones, thus facilitating the facile biocatalytic generation of 1,1′-disubstituted THIQs. Variants ofTfNCS showing improved conversions have been identified and used to synthesize novel chiral 1,1′-disubstituted and spiro-THIQs. Enzyme catalysed PSRs with unactivated ketones are unprecedented, and, furthermore, there are no equivalent stereoselective chemical methods for these transformations. This discovery advances the utility of enzymes for the generation of diverse THIQsin vitroandin vivo.
Tight cohesion between glycolipid membranes results from balanced water–headgroup interactions
Authors: Kanduč Matej , Schlaich Alexander , de Vries Alex H. , Jouhet Juliette , Maréchal Eric , Demé Bruno , Netz Roland R. , Schneck Emanuel
Published: April 2017

Membrane systems that naturally occur as densely packed membrane stacks contain high amounts of glycolipids whose saccharide headgroups display multiple small electric dipoles in the form of hydroxyl groups. Experimentally, the hydration repulsion between glycolipid membranes is of much shorter range than that between zwitterionic phospholipids whose headgroups are dominated by a single large dipole. Using solvent-explicit molecular dynamics simulations, here we reproduce the experimentally observed, different pressure-versus-distance curves of phospholipid and glycolipid membrane stacks and show that the water uptake into the latter is solely driven by the hydrogen bond balance involved in non-ideal water/sugar mixing. Water structuring effects and lipid configurational perturbations, responsible for the longer-range repulsion between phospholipid membranes, are inoperative for the glycolipids. Our results explain the tight cohesion between glycolipid membranes at their swelling limit, which we here determine by neutron diffraction, and their unique interaction characteristics, which are essential for the biogenesis of photosynthetic membranes.
Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer’s disease
Authors: Lim Andrew S. P. , Klein Hans-Ulrich , Yu Lei , Chibnik Lori B. , Ali Sanam , Xu Jishu , Bennett David A. , De Jager Philip L.
Published: April 2017

Circadian and seasonal rhythms are seen in many species, modulate several aspects of human physiology, including brain functions such as mood and cognition, and influence many neurological and psychiatric illnesses. However, there are few data regarding the genome-scale molecular correlates underlying these rhythms, especially in the human brain. Here, we report widespread, site-specific and interrelated diurnal and seasonal rhythms of gene expression in the human brain, and show their relationship with parallel rhythms of epigenetic modification including histone acetylation, and DNA methylation. We also identify transcription factor-binding sites that may drive these effects. Further, we demonstrate that Alzheimer’s disease pathology disrupts these rhythms. These data suggest that interrelated diurnal and seasonal epigenetic and transcriptional rhythms may be an important feature of human brain biology, and perhaps human biology more broadly, and that changes in such rhythms may be consequences of, or contributors to, diseases such as Alzheimer’s disease.
Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases
Authors: Yu Hao , Dranchak Patricia , Li Zhiru , MacArthur Ryan , Munson Matthew S. , Mehzabeen Nurjahan , Baird Nathan J. , Battalie Kevin P. , Ross David , Lovell Scott , Carlow Clotilde K. S. , Suga Hiroaki , Inglese James
Published: April 2017

Glycolytic interconversion of phosphoglycerate isomers is catalysed in numerous pathogenic microorganisms by a cofactor-independent mutase (iPGM) structurally distinct from the mammalian cofactor-dependent (dPGM) isozyme. The iPGM active site dynamically assembles through substrate-triggered movement of phosphatase and transferase domains creating a solvent inaccessible cavity. Here we identify alternate ligand binding regions using nematode iPGM to select and enrich lariat-like ligands from an mRNA-display macrocyclic peptide library containing >1012 members. Functional analysis of the ligands, named ipglycermides, demonstrates sub-nanomolar inhibition of iPGM with complete selectivity over dPGM. The crystal structure of an iPGM macrocyclic peptide complex illuminated an allosteric, locked-open inhibition mechanism placing the cyclic peptide at the bi-domain interface. This binding mode aligns the pendant lariat cysteine thiolate for coordination with the iPGM transition metal ion cluster. The extended charged, hydrophilic binding surface interaction rationalizes the persistent challenges these enzymes have presented to small-molecule screening efforts highlighting the important roles of macrocyclic peptides in expanding chemical diversity for ligand discovery.