bluuebunny/crossref_metadata_2025 huggingface dataset:
In silico Molecular Docking of SARS-CoV-2 Surface Proteins with
Benzimidazole Scaffolds: Strategy to Discover Lead Compounds
Authors: Meghani Monika , Sharma Shikha , Kumar Nitin , Sahoo Biswa Mohan
Published: December 2023

Background:

The severe acute respiratory illness that was brought on because of the
outbreak of COVID-19 caused by the SARS-CoV-2 infection has been designated as a public
health emergency of worldwide concern. There is an immediate and pressing need to establish an
effective therapeutic strategy to bring infections under control. COVID-19 viral spike glycoproteins and proteases both play important roles in the process of viral entrance as well as in the process of virus reproduction.

Methods:

Benzimidazole derivatives show antiviral activity against various RNA and DNA viruses
and stop the early viral replication cycle. Based on this information, we designed eighteen new
benzimidazole derivatives and screened them against the proteins S-glycoprotein 6VSB and papain-like protease 6W9C using molecular docking studies. Compounds that bind strongly to these
proteins were evaluated again in an in vitro study.

Results:

When docked with SARS-CoV-2 spike glycoprotein, the binding affinity of R1 and R7
was –7.1 kcal/mol and -7.3 kcal/mol, respectively. This showed that they might be able to stop the
SARS spike protein from binding to the ACE2 receptor on the human host, making it harder for the
virus to get into the cells. The binding affinity of SARS-CoV-2 papain-like protease with R4, R14,
and R15 was –6.7 kcal/mol, -6.5 kcal/mol, and –6.5 kcal/mol, respectively. COVID-19 could stop
the protease from working by binding it.

Conclusion:

It was suggested, on the basis of the binding energy score, that these pharmacologically potent benzimidazole derivatives may be tested against SARS-CoV-2 and utilized in the production of efficient antiviral medicines
The Interweaving of Pain and Perfection: A Qualitative Inquiry about the
Experiences of Pregnant Women during Pregnancy and Childbirth in the
COVID-19 Pandemic in Iran
Authors: Parandeh Akram , Nehrir Batool , Salaree Mohammad Mehdi , Larki Mona , Makvandi Somayeh , Karimi Leila
Published: December 2023

Background:

The prevalence of the COVID-19 pandemic has made the pleasant experiences of pregnancy and childbirth for women a source of fear and anxiety.

Objective:

To explore the experiences of pregnant women during pregnancy and childbirth in the
COVID-19 pandemic.

Methods:

This qualitative conventional content analysis was conducted in Tehran, Iran, in May and
June 2020. The 15 participants were selected via purposeful sampling including: 12 pregnant women, 2 relatives, and one nurse. Data were collected using in-depth and semi-structured interviews and
the analysis adopted by Graneheim and Lundman (2004). MAXQDA version 12 was used for data
organization.

Results:

According to the findings, 12 sub-categories, 6 categories, and one theme were extracted.
The main theme that was derived from the analysis of the data was " the interweaving of pain and
perfection". The categories include "emotional disorders", "obsessive disorders", "psychological
disorders", "strengthening the dimension of spirituality" "the need for more support resources", and
"inadequacy in presenting the role of motherhood.

Conclusion:

According to the experiences of pregnant women during pregnancy and childbirth during the outbreak of COVID-19, social, psychological, and emotional support through family and
healthcare providers is recommended, as is the formation of virtual counseling groups to answer the
questions of pregnant women. Health policymakers and decision-makers can use the results of this
research to plan for providing services for pregnant women during future pandemics.
Recension: Tanke/världar. Studier i nordisk litteratur
Authors: Nygren Anna
Published: December 2023

Hilda Forss, Hanna Lahdenperä & Julia Tidigs (red.) Tanke/världar. Studier i nordisk litteratur. Helsingfors: NORDICA HELSINGIENSIA 61, 2022, 334 s.
Popularyzacja wiedzy o historii Mazowsza w działalności Muzeum Mazowieckiego w Płocku
Authors: Kordala Tomasz
Published: December 2023

W artykule omówiono sposoby popularyzacji wiedzy o przeszłości Mazowsza stosowane w Muzeum Mazowieckim w Płocku od momentu jego powstania, w ramach Towarzystwa Naukowego Płockiego, w 1821 r. Miało ono charakter stricte regionalny. Zbiory tworzyły z jednej strony szkolne pomoce nauko- we (minerały, aparaty fizyczne i chemiczne, globusy etc.), z drugiej zaś – ofiarowane przez nauczycieli, uczniów, obywateli ziemskich, wojskowych i księży różnorodne eksponaty, w tym liczne zabytki arche- ologiczne, monety, medale, okazy przyrodnicze, dokumenty etc. Na posiedzeniach naukowych referowa- no najnowsze znaleziska archeologiczne i numizmatyczne, organizowano inspekcje terenowe, zbierano zabytki przeszłości i umieszczano je w muzeum. Placówka ta zamarła wkrótce po upadku Powstania Listo - padowego. Do jej reaktywacji doszło na początku XX w. W grudniu 1912 r. otwarto w gotyckiej kanonii przy Rynku Kanonicznym 8 stałą ekspozycję obrazującą przeszłość geologiczną i historyczną oraz etno- grafię Mazowsza Płockiego. W 1930 r. baza lokalowa powiększyła się o zakupiony Dom pod Opatrznością przy Rynku Kanonicznym 2, w którym urządzono ekspozycje – przyrodniczą, geologiczną, etnograficzną, archeologiczną. Do 1949 r. placówka, nosząca nazwę Muzeum Mazowsza Płockiego, była częścią Towa- rzystwa Naukowego Płockiego. Po tej dacie rozpoczął się nowy etap w jej historii, etap samodzielnego rozwoju. Budowa kombinatu petrochemicznego w Płocku w latach 60. XX w. przyczyniła się do znaczą- cego rozwoju placówki. Uzyskała ona nową siedzibę w odrestaurowanym Zamku Książąt Mazowieckich (Opactwie Benedyktyńskim) na Wzgórzu Tumskim, co przełożyło się na powiększenie powierzchni wysta- wienniczej oraz wzrost liczby pracowników ze specjalistycznym wykształceniem. W 1993 r. muzeum otrzymało budynek zabytkowego spichlerza na skarpie nad Wisłą, w którym ulokowano zbiory Działu Etnografii. W listopadzie 2004 r. przeniesiono zbiory z Zamku Książąt Mazowieckich do kamienicy sece- syjnej przy ul. Tumskiej 8 i urządzono tam stałą ekspozycję sztuki secesyjnej. W kolejnych latach nastąpił dynamiczny rozwój muzeum, tak pod względem bazy lokalowej, jak i programu działania na każdym praktycznie polu, także w zakresie popularyzacji wiedzy historycznej. Pojawiły się nowe pawilony muze- alne i nowe ekspozycje stałe. Obecnie aktywność popularyzatorska Muzeum Mazowieckiego w Płocku obejmuje szeroką gamę działań realizowanych przez Dział Upowszechniania i Promocji oraz poszczegól- ne działy merytoryczne. Są to lekcje muzealne, prelekcje historyczne, sesje naukowe, warsztaty dla dzieci i osób niepełnosprawnych, imprezy plenerowe, promocje wydawnictw, koncerty, konkursy, filmy edu- kacyjne, periodyki („Rocznik Muzeum Mazowieckiego w Płocku”, „Nasze Korzenie”, „Biuletyn Muzealny”), widowiska parateatralne i wiele innych. Słowa kluczowe: dziedzictwo kulturowe Mazowsza, regionalizm, popularyzacja wiedzy historycznej, Muzeum Mazowieckie w Płocku, Towarzystwo Naukowe Płockie
An Online Psychological Program for Adolescents and Young Adults With Headaches: Iterative Design and Rapid Usability Testing (Preprint)
Authors: Huguet Anna , Rozario Sharlene , Wozney Lori , McGrath Patrick J
Published: December 2023

BACKGROUND

Headache disorders are common, debilitating health problems. Cognitive-behavioral therapy (CBT) is recommended but rarely easily available. With the use of the internet and communication technologies among youth and young adults, these individuals could be self-trained in CBT skills. There is an increasing number of internet-based interventions for headaches, but there has been little research into the usability of these interventions because evaluating usability across the intervention development life cycle is costly. We developed an internet-based CBT program, the Specialized Program for Headache Reduction (SPHERE). While developing it, we aimed to improve SPHERE through rapid usability testing cycles.

OBJECTIVE

This study aims to presents a rapid and affordable usability testing approach that can be performed throughout the intervention development life cycle. This paper also provides evidence of the usability of SPHERE.

METHODS

We used the “think aloud” usability testing method based on Krug’s approach to test user interaction within a lab setting. This was followed by a short posttest interview. We planned to test SPHERE with 3-5 participants testing the same part of the program each cycle. Both the design and development team and the research team actively participated in the usability testing process. Observers independently identified the top 3 usability issues, rated their severity, and conducted debriefing sessions to come to consensus on major issues and generate potential solutions.

RESULTS

The testing process allowed major usability issues to be identified and rectified rapidly before piloting SPHERE in a real-world context. A total of 2 cycles of testing were conducted. Of the usability issues encountered in cycles 1 and 2, a total of 68% (17/25) and 32% (12/38), respectively, were rated as major, discussed, and fixed.

CONCLUSIONS

This study shows that rapid usability testing is an essential part of the design process that improves program functionality and can be easy and inexpensive to undertake.
Thoughts and Experiences of Behçet Disease From Participants on a Reddit Subforum: Qualitative Online Community Analysis (Preprint)
Authors: Li Jenny Xiaoyu , Yacyshyn Elaine
Published: December 2023

BACKGROUND

Behçet disease (BD) is a type of vasculitis with relapsing episodes and multisystemic clinical features, associated with significant morbidity and impact on patients’ lives. People affected by BD often participate in discussions of their illness experiences. In-person support groups have limited physical accessibility and a relative lack of anonymity; however, online communities have become increasingly popular.

OBJECTIVE

This study investigates the perspectives and experiences of people affected by BD by examining the content shared and discussed on a subforum of the website Reddit—a popular online space for anonymous discussions.

METHODS

All discussion threads posted between March 9, 2021, and March 12, 2022, including posts and comments, were examined from the subforum “r/Behcets,” an anonymous online community of 1100 members as of March 2022. A Grounded Theory analysis was completed to identify themes and subthemes, and notable quotes were extracted from the threads. Parameters extracted from each post included the number of comments, net upvotes, category, and subcategories. Two research team members read the posts separately to identify initial codes and themes to ensure data saturation was achieved.

RESULTS

Six recurring themes were identified: (1) finding connectedness and perspectives through shared experiences, (2) struggles of the diagnostic odyssey, (3) sharing or inquiring about symptoms, (4) expressing strong emotions relating to the experience of BD, (5) the impact of BD on quality of life and personal relationships, as well as (6) COVID-19 and the COVID-19 vaccination in relation to BD. Subthemes within each theme were also identified and explored.

CONCLUSIONS

This novel study provides a qualitative exploration of the perspectives and experiences of people affected by BD, shared in the anonymous and accessible online community of Reddit. The study found that people impacted by an illness seek to connect and receive validation through shared conditions and experiences. By examining the content shared in r/Behcets, this study highlights the needs of people affected by BD, identifying gaps and areas for improvement in the in-person support they receive.
Effect of Baduanjin Qigong on Sleep Quality and Hyperarousal State in Adults With Chronic Insomnia: Protocol for a Randomized Controlled Trial (Preprint)
Authors: Xie Chaoqun , Xie Fangfang , Ma Jianwen , Yue Hongyu , You Yanli , Yao Fei
Published: December 2023

BACKGROUND

Chronic insomnia (CI) is a mind-body disease that is commonly defined as a state of having disturbed daytime activities due to poor nighttime sleep quality. Baduanjin qigong (BDJQG) is widely used for CI in China. However, there is little scientific evidence to evaluate its effects on the hyperarousal state, which is closely associated with improved sleep quality.

OBJECTIVE

The objective of the trial is to assess the therapeutic effects of BDJQG on sleep quality in patients with CI.

METHODS

A randomized controlled trial will be conducted on 86 patients, who will be divided into a BDJQG group and a cognitive behavioral therapy for insomnia group at a ratio of 1:1. Interventions in both groups will be given to the participants 7 times a week for 8 weeks, and the participants will be followed up for 4 weeks. The primary outcome is the change in the Pittsburgh Sleep Quality Index from baseline to week 8. The secondary outcomes are the changes in the Hyperarousal Scale, Insomnia Severity Index, Fatigue Scale-14, wrist actigraphy, salivary cortisol level, and functional magnetic resonance imaging from baseline to week 8. All main analyses will be carried out on the basis of the intention-to-treat principle.

RESULTS

This study was funded from January 2023. As of the submission of the manuscript, there were 86 participants. Data collection began in April 2023 and will end in January 2024. Data analysis is expected to begin in January 2024, with the publication of results expected in February 2024.

CONCLUSIONS

This study will present data concerning the clinical effects of BDJQG on CI. The results will help to demonstrate whether BDJQG is an effective therapy for improving sleep quality in association with a decreased hyperarousal level as a possible underlying mechanism. This study will provide much-needed knowledge for complementary and alternative therapy for patients with CI.

CLINICALTRIAL

China Clinical Registration Agency ChiCTR2300069241; https://chictr.org.cn/bin/project/ChiCTR2300069241

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/53501
Validity, accuracy, and safety assessment of an aerobic interval training using an App-based prehabilitation program before major surgery: PROTEGO-MAXIMA-Trial. A prospective, interventional pilot study (Preprint)
Authors: Schnitzbauer Andreas
Published: December 2023

UNSTRUCTURED

Background: Major surgery is associated with substantial morbidity and reduced quality of life, particularly in the elderly and frail with impaired functional capacity. Multimodal prehabilitation can enhance functional recovery after surgery and reduce postoperative complications. Digital prehabilitation applications gained momentum being a resource-sparing tool improving patients’ preoperative status. Still, little is known regarding their safety and accuracy as medical devices.
Methods: The PROTEGO MAXIMA trial was a prospective interventional pilot trial assessing the validity, accuracy, and safety of an app-based exercise program. The Prehab App calculates an individual, risk-stratified aerobic interval training based on risk factors and uses wearables for heart rate monitoring. Healthy students and patients undergoing major surgery were enrolled. Structured risk assessment was performed followed by a 6-min walking test and a 37-min supervised interval. During the exercise, patients wore App-linked wearables for heart rate and distance measurement, which were compared to standard ECG and treadmill measurements. Safety and usability assessments included testing of alarm signals, and occurrence of adverse events.
Findings: Seventy-five participants were included. Mean heart rate differences between wearables and standard ECG were ≤5bpm with a mean absolute percentage error (MAPE) ≤5%. Regression analysis revealed a significant impact of the body mass index (BMI) (OR 0·897, 95% CI [0·822, 0·980], P = 0·016) and TUG-score (OR 0·122, 95% CI [0·027, 0·546], P = 0·006) on the accuracy of heart rate measurement. Twenty-nine (38·7%) patients experienced adverse events: pain (41·7%), ECG electrode-related skin irritations (16·7%), dizziness (16·7%), shortness of breath (16·7%), and fatigue (8·2%). No cardiovascular, or serious adverse event was reported, and no serious device deficiency was detected.
Interpretation: The interventional trial showed high safety of the exercise program and accuracy of heart rate measurements using commercial wearables in patients before major surgery allowing a remote setting in the future.
Funding: Else-Kroener-Fresenius Stiftung (number: 2021_EKTP10).
Apakah Risiko ESG Berkaitan dengan Risiko Perusahaan?
Authors: Firmansyah Amrie , Kharisma Andy Novendra , Amalia Rizky
Published: December 2023

Selama beberapa tahun terakhir, telah terjadi lonjakan minat terhadap isu-isu lingkungan, sosial, dan tata kelola (ESG). Integrasi ESG telah menjadi aspek penting dalam pengambilan keputusan investasi. ESG merupakan faktor non keuangan yang menjadi perhatian bagi investor terkait dengan kondisi perusahaan. Perusahaan yang mengungkapkan aktivitas ESGnya menunjukkan bahwa perusahaan memiliki risiko ESG yang rendah dan sebaliknya. Tujuan penelitian ini adalah untuk menguji pengaruh risiko ESG terhadap risiko perusahaan.  Penelitian ini menggunakan data laporan keuangan tahun 2022 perusahaan yang terdaftar di Bursa Efek Indonesia dan memiliki skor risiko ESG oleh lembaga penilai yaitu Morningstar Sustainalytics pada tahun 2022. Data laporan keuangan perusahaan diperoleh dari www.idx.co.id, sedangkan data risiko ESG diperoleh dari https://finance.yahoo.com/. Penelitian ini menggunakan sampel sebanyak 76 observasi berdasarkan purposive sampling. Pengujian hipotesis dilakukan dengan menggunakan analisis regresi linear berganda untuk data cross-section. Hasil penelitian ini menunjukkan bahwa risiko ESG tidak berpengaruh terhadap risiko perusahaan di Indonesia. Penelitian ini menunjukkan bahwa informasi ESG bukan merupakan informasi yang penting dalam menilai kondisi perusahaan di pasar modal.
STRESS LEVEL OF MEDICAL STUDENTS IN ONLINE LEARNING DURING COVID-19 PANDEMIC AND ITS IMPACT ON ACADEMIC ACHIEVEMENT
Authors: Tjang Yanto Sandy , Prihatiningsih Titi Savitri , Prabandari Yayi Suryo
Published: December 2023

research on its prevalence is still very few and inconclusive. The relationship between stress and academic achievement in medical students remains a matter of debate. This study aims to determine the stress level of medical students in online learning during the COVID-19 pandemic and its impact on academic achievement.Method: This descriptive-analytical study used a cross-sectional design on undergraduate medical students from the 2019-2021 class. The questionnaire distributed online contained questions related to characteristics of respondents, 14 questions from DASS-42 questionnaire to measure stress, and questions related to respondents' perceptions of online learning and semester achievement index (IPS). Data were analysed descriptively and analytically using logistic regression method with the help of SPSS Statistics 26 software. Results: Of 431 students, 411 (95%) students participated in this study. The prevalence of stress in respondents was 41.8%, majority was mild (13.4%) and moderate (13.9%). Lack of interaction between lecturers and students increased 1,691 times the risk of stress. A total of 403 (98.1%) respondents had IPS ≥ 3. Stress on respondents did not have negative impact on academic achievement, although statistically not significant (OR = 0.831; 95% CI = 0.196-3.524; p-value 0.801).Conclusion: The prevalence of stress for medical students in online learning during COVID-19 is quite high, majority was mild and moderate. Lack of interaction between lecturers and students increased risk of stress. Majority of respondents have good IPS. Stress on respondents apparently did not have negative impact on academic achievement.
ONLINE LEARNING SURVEY OF PUBLIC HEALTH STUDENTS IN A HEALTH SCIENCES FACULTY
Authors: Wicaksono Arif
Published: December 2023

Background: Coronavirus Disease 2019 (COVID-19) pandemic had an impact on all sectors including the education sector. The world of conventional education that prioritizes offline learning in one class was required to turn into offline learning through information technology in order to prevent the transmission of COVID-19 disease. Relatively new online learning process in Indonesia will have a real impact on educational institutions and students.Aims: This survey aimed to find out the characteristics of students, perceptions of online learning, the effectiveness of online learning, and the obstacles found when online learning from the student’s side.Case description: The survey was conducted using a list of questions in the google form filled out by students of the Universitas X Pontianak which were taking Basic Biomedical 2 online course in the second semester of the academic year 2019/2020 in May 2020. A total of 30 students were participated in the survey. Respondents get the most internet access from mobile phone quotas and only 20% of respondents get good internet access conditions. Twenty-six point sixty-seven percent of respondents agreed with online learning and 10 percent of respondents said online learning was effective. internet signal conditions, difficulty understanding the material, too much assignment, and insufficient time are obstacles obtained when learning online. Conclusion: Education institutions and stakeholders should always conduct evaluations, improvements, and updates for facilities and human resources involved in online learning.
TARGETING ACADEMIC SURGEONS RESTORING THE DIGNITY OF SURGICAL EDUCATION-TRAINING IN INDONESIA: A MODEL OF EXCELLENCE IN PROFESSIONAL ACHIEVEMENT
Authors: Lalisang Toar Jean Maurice
Published: December 2023

Background: Due to the dynamic changes in the strategic environment and development of science and technology, the Indonesian national education system has undergone various adjustments, including surgeons' education training programs. To some extent, various essential changes, marginalization, and pragmatization of surgical services have degraded the dignity of surgical education-training programs in Indonesia. This study aims to analyse several causal factors appropriately to direct to an appropriate target based on the present and future situation to prevent inappropriate solutions.Methods: This narrative review is based on related articles freely downloaded, which discuss the what and why of uncertainty in the provision of education-training today and suggest how changes must be made to restore the dignity of Surgeons in Indonesia. Current Indonesian conditions are mainly based on implementation at the Surgery Department, Medicine of Faculty Universitas Indonesia and Cipto Mangunkusumo Hospital.Results: It is challenging to obtain data on evaluating the educational process and the quality of surgeon graduates. Based on observation, there are four main problems, including the recruitment of teaching staff, Ministry of Education and Culture policies, adequateness of learning materials, and the phenomenon of semester-based graduation. These problems lead to quasi-referral and case management of defensive surgery, which gradually declines the surgeon profession's dignity.Conclusion: The fundamental solution to restoring the dignity of surgeons in Indonesia is to provide an education-training which produce academic surgeons.
TRANSLATION AND CROSS-CULTURAL ADAPTATION OF GENERIC SKILL SELF-ASSESSMENT INSTRUMENT FOR INDONESIAN UNDERGRADUATE MEDICAL STUDENTS
Authors: Puspadewi Natalia , Anastasia Gisella , Rukmini Elisabeth
Published: December 2023

Background: There are various educational strategies that promote generic skills development in medical education; hence, there is a need for a valid and reliable instrument to assess them. This study aims to translate and adapt a generic skills self-assessment instrument developed by Groen et al.1 to assess Indonesian medical student’s generic skills in a classroom context.Methods: WHO's guidelines were used for the translation process, which consisted of: 1) forward translation, 2) expert panel review (using the Delphi method), 3) back translation, 4) pre-testing and cognitive interviews, and 5) the final version. Additional measures were employed to improve the translation accuracy, including proofreading (prior to step 2), expert panel review after step 3 and 4, and pilot testing along with psychometric testing after step 5. Backward translation was done by a professional translation service. Ten fourth-year students from Atma Jaya School of Medicine and Health Sciences were involved in step 4; meanwhile, we piloted the translated instrument to 35 other fourth-year students from the same sample pool. We also conducted an internal reliability test using Cronbach's alpha and construct validity test, including corrected total-item correlation and principal component analysis.Results: Steps 1-3 produced an Indonesian version of the generic skills assessment instrument with good face and content validity. Quantitative data analysis showed high internal reliability (Cronbach’s Alpha = .955) and acceptable item-total correlation (ranging from .345 to .757).Conclusion: Factor analysis showed 6 domains labelled as analytical skills, teamwork, communication skills, perseverance, social judgment, and global abstraction skills.
Impact of Forensic Accounting on Fraud Detection in Zimbabwes Public Sector Expenditure Cycle
Authors: Murinda Gibson Tangai , Chiwariro Ronald
Published: December 2023

Abstract: The objective of this study was to evaluate the influence of forensic accounting on the discovery of fraudulent activities within the public sector of Zimbabwe, specifically examining the expenditure cycles of government departments. The investigation was sparked by the Auditor General's disclosure of governance problems and the rise in qualified audit opinions observed from 2018 to 2022. During that time period, the government imposed additional restrictions, such as a directive to freeze payments for all contracts that had been submitted for payment, a requirement to conduct due diligence checks on all contracts with the assistance of internal audit staff, and the blacklisting of 19 companies in an effort to get value for money, as well as a reduction in the huge appetite for business travel by government officials (Treasury Circular number 5 of 2023) served as another impetus for the research.
A Comparative Analysis of Seismic Behavior of Regular and Irregular Shaped Buildings with OMRF and SMRF Structural Systems: A Review
Authors: . Virendra
Published: December 2023

Abstract: These days, modern residential buildings are getting higher and higher. The way these structures perform is significantly impacted by the impact of lateral loads from wind and earthquakes. It is impossible to completely prevent irregularities when building. It is mandatory to investigate how these irregularly shaped structures behave during earthquakes. The behaviour of regular and irregular buildings is represented in this study. As a result of the irregular plan and elevation configurations of various buildings in the current situation, which could be subject to hazadous earthquakes in the future, it is necessary to assess how well the structures are performing in terms of their ability to withstand disasters, primarily earthquakes. This project aims to compare the seismic behaviour of regular-shaped buildings with OMRF and SMRF structural systems versus. The study will make use of STAAD-Pro software, and the buildings' performance will be evaluated according to several criteria. The results of the research will broaden our understanding of earthquake engineering and provide insight into the performance of OMRF and SMRF structural systems in both regularly shaped and irregularly shaped buildings.
Learning with Augmented Reality
Authors: Pandey Rajiv Kumar
Published: December 2023

Abstract: Modern society is increasingly permeated by realities parallel to the real one. The so-called virtual reality is now part of both current habits and many activities carried out during the day. Virtual reality (VR) is, in turn, related to the concept of augmented reality (AR). It represents a technology still in solid expansion but which was created and imagined several decades ago. This paper presents an overview of augmented reality, starting from its conception, passing through its main applications, and providing essential information. Part of the article will be devoted to hardware and software components used in AR systems. The last part of the paper highlights the limitations related to the design of these systems, the shortcomings in this area, and the possible future fields of application of this extraordinary technological innovation.
Ārpolitiskās identitātes idejas kā “ceļa karte” Krievijas karadarbībai Ukrainā
Authors: Vrobļevska Elīna
Published: December 2023

Krievijas rīcību Ukrainā var skatīt kā daļēju atbildi Kremļa apdraudējuma izjūtai un arī kā atbilstošu Putina vēlmei aizsargāt Krievijas identitāti Rietumu vērtību kontekstā.
Daugavas vidusteces palienes spēja akumulēt palu ūdeņus
Authors: Gruberts Dāvis
Published: December 2023

Daugavas vidusteces paliene būtiski samazina plūdu riskus Jēkabpilij, pazeminot maksimālo iespējamo ūdens līmeņa augstumu pilsētā.
Izravni demografski gubitci Vukovarsko-srijemske županije u Domovinskom ratu
Authors: Živić Dražen
Published: December 2023

Demografski, društveni i gospodarski razvoj Vukovarsko-srijemske županije u Domovinskom ratu i nakon njega odvijao se pod signifikantnim utjecajem demografskih ratnih gubitaka kao i dugoročnih demografskih, društvenih i ekonomskih posljedica rata i višegodišnje okupacije dvije trećine županijskoga teritorija. Na temelju dostupnih podataka u ovom su radu utvrđeni i opisani izravni demografski gubitci Vukovarsko-srijemske županije te ocijenjen njihov utjecaj na demografske promjene u Županiji u „ratnom“ međupopisju (1991. – 2001.).
Stanje gospodarstva vukovarskog kraja na prijelazu iz 19. u 20. stoljeće na temelju izvještaja o stanju javne uprave Županije srijemske
Authors: Živić Vinko , Kevo Mario
Published: December 2023

Na temelju izvora i literature autori prikazuju najznačajnije elemente koji su utjecali na gospodarski razvoj grada i kotara Vukovar na prijelazu iz 19. u 20. stoljeće. Kao gradsko središte te sjedište Srijemske županije, Vukovar je smješten na iznimno povoljnom prometnom položaju koji karakterizira plovnost rijeke Dunav što je, među inim, bio jedan od temelja gospodarskog razvoja tog kraja. Pod utjecajem niza političkih, društvenih i prirodno-geografskih elemenata, Vukovar se mijenja i oblikuje prerastajući u jednu od najznačajnijih gospodarskih točaka istočne Slavonije i Srijema.
The role of women in the production and distribution of series in Yugoslavia - creators of socialist cultural heritage
Authors: Milosavljevic Ilija , Ercegovac Ivana , Carroll Anna
Published: December 2023

The paper deals with the research of the presence and roles of women in the
creation of series in socialist Yugoslavia during the sixties and seventies
of the 20th century. Besides the primary objective of identification, this
study aims to identify specific patterns in work allocation, highlight
significant female contributors, and underscore their contributions to the
development of television series, thereby shedding light on values, cultural
patterns, and societal practices. Also, Cultural Identity Theory was
implemented to provide a valuable framework for understanding how women?s
contributions behind the scenes in Yugoslav television series production
during the 1960s and 1970s are intricately linked to the construction of
cultural identity. Further, the paper analyzes the list of employees
involved in the creation of 17 Yugoslav series created during the 1960s and
1970s. All information about the employees was found on the site IMDB.com.
With the help of a specially constructed code list, they were listed and
classified, and descriptive and comparative statistics of data analysis were
carried out in the SPSS 24.0 program. In the second part of the analysis,
the most significant women in this process were singled out and presented.
The results clearly demonstrate that women held significantly fewer
positions than men, with a distinct division of labor based on gender roles.
Men are more often those who relate to the main positions in making series,
and women to logistics and aesthetics of the characters. Also, the
conclusion of the research is that, in order to be successful, a woman in
that period often had to be supported by a man, but that, when she was
recognized, she played a significant role in many projects, thus
participating in defining the cultural heritage of an entire era.
Mapping oil palm expansion within the protected lowland rainforest of Nigeria using Google Earth engine
Authors: Adewoye Ralph , Ukoha Peace , Okonkwo Stephen
Published: December 2023

Increasing demand for Elaeis guineensis (African Oil Palm) products both for domestic and industrial use has led to its continuous expansion. The influence of oil palm plantation establishment on the economic well-being of communities and ecosystems cannot be over-emphasised. The study focuses on the rapid expansion of oil palm plantations within all protected areas and forest reserves in the lowland rainforests of Ondo State, Nigeria using. Object-Based Image Analysis (OBIA) was used to map oil palm expansion using 10-metre resolution Sentinel-2A images for 2015 and 2020 in Google Earth Engine (GEE). We found expansion of both smallholder and commercial oil palm plantations within eight of the thirteen protected areas with three protected areas (Ipele, Onisere and Akure Ofosu) showing a significant increase in oil palm plantation establishment. The use of object-based classification techniques, which combines contextual information within the image domain to discriminate landscape features such as oil palm canopy features, was effective in delineating oil palm from the forest canopy and other crops. While Google Earth Engine, a server-based remote sensing domain with petabytes of data, is effective for monitoring large-scale tropical forests.
The State of Ukraine's Protected Areas: an interim update on damages from the full-scale invasion
Authors: Timmins Hannah , Petrovych Olesya , Drapaliuk Anastasiia , Polianska Kateryna , Vasyliuk Oleksii , Bragger Jody , Kuzemko Anna , Vishnevsky Denis
Published: December 2023

The Russian Federation’s full-scale invasion of Ukraine has become a humanitarian and political crisis. Since the very start of the invasion, it has also been an ecological disaster, with Russian troops utilising protected areas both in an attempt to access strategic Ukrainian settlements, but also as locations in which to conduct active warfare. The frontline has now crossed and retreated from many protected areas, many are still occupied and many are still the sites of active hostilities. This study found the most common damages to protected areas are: physical destruction of habitats and wildlife and wildlife behavioural changes from explosions; chemical and physical pollution from explosive materials; fires caused by shelling; damages to soil and plant cover from heavy military vehicles, equipment and defence infrastructure; and military exploitation of natural resources. Given the occupation, combat and mining with explosives, it will be years before Ukraine can account for the full extent of damage to its protected area system. This paper provides an interim assessment of the damages to protected areas so far and urges the conservation and policy communities to monitor the situation moving forward.
The incidence of late-detected developmental dysplasia of the hip and its functional outcomes: a 17-year cohort study using selective ultrasound screening
Authors: Håberg Øyvind , Foss Olav Andreas , Gundersen Trude , Bjerkestrand Lian Øystein , Slettvåg Hoel Myrthle , Holen Ketil J
Published: December 2023

Background and purpose: We aimed to establish the incidence of late-detected developmental dysplasia of the hip (DDH) with a selective ultrasound (US) examination over 17 years using the femoral head coverage (FHC) as a US measurement. The secondary aim was to establish the everyday function using patient-reported outcome measures (PROMs).Patients and methods: The incidence of late-detected DDH was based on 60,844 children. Patients diagnosed for the first time after 3 months and before the age of 8 years were included. In the second part of the study, consent to participate was mandatory. PROMIS-25 Pediatric, PROMIS-25 Parent, and EQ-5D-5L were used according to the patient’s age to assess everyday function.Results: The incidence of late-detected DDH was 0.48/1,000. The median age at diagnosis was 8 months (range 4–41 months), with a tendency to require repeated treatment with open surgery if DDH was diagnosed later. Most children reported no or minor health problems with a mean of 18 years’ follow-up.Conclusion: We found that selective US examination of the hips by measuring the FHC is a reliable method to examine newborns for DDH resulting in a low incidence of late-detected DDH amounting to 0.48/1,000 newborn children.
Western frontier of the Archaic Scythia: typo-chronology vs radiocarbon dating
Authors: Grechko Denis
Published: December 2023

One of the key issues in the chronology of Late Hallstatt period is the so-called Hallstatt plateau in the calibration curve extending the calibrated range of single dates to c. 800-400 BC. Analysis of the 14C dates of the ash-hill from the Chotyniec hillfort, indicate its dating to the time range, which does not exceed the interval of 780-469 BC. Typological analysis of the artefact collection allows us to date the ash-hill to the middle of the 7th – the first third of the 6th century BC (HaС2-HaD1). This dating corresponds to the Early Scythian timeand chronology of the Western Podillian group. The analysis of material culture allows us to indicate the immediate closeness of the Chotyniec agglomeration to the Western Podillian group.
From Kiev to Pereyaslavets (Πρεσθλαβίτζα). The early medieval stone egg imitations and glazed Easter egg rattles from Dobrudja, Romania.
Authors: Szmoniewski Bartlomiej Szymon , Stănică Aurel Daniel
Published: December 2023

This article focuses on the finds of glazed egg-shaped rattles as well as on egg imitations of chalk and of Romanbricks discovered in Dobrudja and in nearby Varna. It is assumed that they were used in magical and religiousrituals connected with fertility and vegetation cults, as well as in apotropaic and healing rites. Chalk imitations dated prevailingly to the 10th century could be relics of a local Christian-pagan syncretism. Glazed items were most probably imports from Kyiv workshops in Kyivan Rus’. The latter should be associated with the presence of people engaging in military operations led by Rus’ princes, namely mercenaries and even more probably, with merchants travelling along the waterways leading from the Varangians to the Greeks. This route was most intensively exploited in the time from the middle of the 10th to the middle of the of 11th century, which correlates with the chronology of the layers and graves where these glazed eggs were discovered, their dating points mainly being to the 11th century.
Intrusions of the steppe population into the Balkan-Carpathian region in the Early Bronze Age: factors and aspects
Authors: Ivanova Svitlana
Published: December 2023

The Budzhak culture of the Northwest Pontic region is a part of the Yamna cultural-historical area. Its social hierarchy and the identification of “ritual groups” within it provide important evidence when considering intrusions of the steppe population into the Balkan-Carpathian region. Certain elite grave goods are often associated with individuals buried in certain positions that allow the identification of “ritual groups”. One of these is characterized by supine inhumation with flexed legs, arms stretched along the body. These had high social status in the context of the Budzhak culture and they are the ones that were widespread in Europe. In addition to the well-known Danubian route, other paths from the steppe to the west can be considered (Carpathian-Transylvanian and Prut-Dnistr routes). The principal aim of the movement to the west was probably to obtain metals, which could be exchanged for salt from the estuaries of the Northwest Pontic area.
Remediation of Toxic Cu (II) with Acrylamide-Based Hydrogels
Authors: Çankaya Nevin
Published: December 2023

Industrial developments and increasing urbanization increase the concentration of heavy metals in wastewater. Hydrogel composites are used as adsorbents for the removal of heavy metals from wastewater. In this study, superabsorbent hydrogels were synthesized and characterized using carboxymethyl cellulose (CMC) as biopolymers, halloysite (HNT) and montmorillonite (MMT) as clays, acrylamide (AM) and 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPS) as monomers. Poly(ethylene glycol) diacrylate (PEGDA) was used as cross linker, tetramethylenediamine (TEMED) as accelerator, and ammonium persulfate (APS) as initiator. The effect of the co-monomer AMPS on Cu(II) remediation was determined by changing its ratio in the hydrogel. CuSO4 .5H2 O and Cu(NO3 )2 aqueous solutions were used to determine the Cu(II) remediation capacity of the hydrogels. Infrared Spectroscopy (UATR) was used for spectroscopic characterization of hydrogel composites and UVvis spectrophotometer was used for Cu(II) adsorption measurements. In the CuSO4 .5H2 O adsorption study at pH=neutral, adsorption % increased with increasing AMPS amount in AMPS containing hydrogels, while in the Cu(NO3 )2 adsorption study at pH~1, adsorption % decreased with increasing AMPS amount in AMPS containing hydrogels.
Artificial Intelligence in Clinical Trials- Future Prospectives
Authors: Gnanasambandam Anjali
Published: December 2023

Clinical trials are essential for delivering novel medications, technology, and procedures to the market and clinical practice. Only 10% of these studies complete the entire procedure from the drug design to the four phases of development, because clinical trials are becoming more expensive and difficult to perform. The population's health, standard treatment, health economics, and sustainability suffered greatly from this low completion rate. Artificial intelligence (AI) is one of the tools that could streamline some of the processes which are the most tedious operations, like patient selection, matching, and enrollment; better patient selection could also minimize harmful treatment and its side effects. The widespread implementation of AI technology in clinical trials still faces many challenges and requires more high-quality prospective clinical validation. In this review, we discussed the prospective applications of AI in clinical research and patient care in the future
Phytochemistry, Analgesic and Anti-Inflammatory Activities and Acute Toxicity Studies of Phragmanthera Usuiensis (Oliv.) M.G. Gilbert
Authors: Wainaina Samuel M
Published: December 2023

Plants have played a significant role in healthcare throughout history by providing medicinal substances. Phragmanthera usuiensis leaves have been used by traditional practitioners for the treatment of oxidative stress-related diseases in the study area, primarily for treating arthritis. The objective of the study was to investigate the phytochemical composition, analgesic effect, anti-inflammatory effect, and acute toxicity of the methanolic extract of P. usuiensis leaves. The phytochemical composition of the methanolic extract of P. usuiensis leaves was studied using qualitative and quantitative methods. The analgesic effect was investigated through the hotplate method, and the anti-inflammatory activity through the carrageenan-induced paw edema model. Investigation of acute toxicity was carried out as per the OECD guidelines on acute oral toxicity – Acute Toxic Classic (ATC) method, with the acute toxicity being administered orally by gavage. Treatment of the animals was initiated at the starting dose level of 300 mg/kg body weight and carried out with six animals (three animals per step). Treatment of animals at the next dose of 2000 mg/kg body weight was delayed until the survival of the previously dosed animals was ensured. The methanolic extracts of P. usuiensis possess several phytochemicals that exhibited promising free analgesic and anti-inflammatory effects. The phytochemicals found in the methanol extract include alkaloids, tannins, glycosides, saponins, steroids, flavonoids, terpenoids, phenols, coumarins, and free sugars. All groups of test animals did not exhibit any serious toxic or lethal effects even at the administration of the limit dose, 2000 mg/kg body weight. The study has successfully validated the use of Phragmanthera usuiensis leaf as having activity that potentially can be used to treat oxidative stress-related disorders like arthritis. Moreover, the study confirmed that these plants exhibit analgesic and anti-inflammatory actives. Additionally, it established the safety of the extracts for use as medicinal agents in the management of oxidative stress.
Mutable and Slimy-Myxoid Pleomorphic Liposarcoma
Authors: Bajaj Anubha
Published: December 2023

Myxoid pleomorphic liposarcoma is an exceptionally discerned, aggressive variant of liposarcoma predominantly incriminating young individuals. The preponderantly hybrid tumefaction demonstrates an amalgamation of morphological features of myxoid liposarcoma and pleomorphic liposarcoma. Additionally designated as pleomorphic myxoid liposarcoma, myxoid pleomorphic liposarcoma is a soft tissue tumour delineating an aggressive clinical course and inferior overall survival. Commonly, tumefaction is devoid of FUS/EWSR1-DDIT3 genetic fusions or MDM2 genomic amplification. Commonly, myxoid pleomorphic liposarcoma incriminates young subjects < 30 years. However, few lesions may occur within older adults. A specific gender predilection is absent. Nevertheless, a mild female preponderance or an equivalent gender predisposition may be encountered
Death and Beyond: Recent Insights and Technological Approach in Artificial Intelligence
Authors: Rawal Rakesh
Published: December 2023

Artificial intelligence (AI) is a field of computer science that focuses on developing cognitive computing systems capable of mimicking human-like behavior. AI is a man-made technology that enables machines or software applications to learn from real-world experiences or patterns to make predictions and generate new valuable insights through precise computations. In recent advancements in forensic medicine, devices and machines have been developed to measure, diagnose, and characterize virtual autopsies and biological omics data using AI algorithms. These technologies enable various forensic applications, including ballistic wound age estimation and postmortem interval (PMI) prediction by analyzing different biomarkers. Additionally, electronic noses have been designed to replicate the mammalian olfactory system for the purpose of detecting and classifying odor mixtures, which can also aid in estimating the PMI. While artificial intelligence offers valuable tools and insights to forensic pathologists, its implementation raises important ethical and legal concerns. It has the potential to impact the criminal justice system, and the integrity of these technologies must be carefully considered in future legal investigations. The implications of AI in law enforcement are profound, as "intelligent" algorithms are used to make critical determinations about individuals' guilt or innocence, necessitating the collection of unbiased and accurate data. The frameworks that underpin these algorithms, as well as the individuals responsible for their development, play a pivotal role in shaping the future of AI in forensic science and the legal system.