bluuebunny/crossref_metadata_2025 huggingface dataset:
Caffeine Alkaline Hydrolysis and in Silico Anticipation Reveal the Origin of Camellimidazoles
Authors: Le Pogam Pierre , POUPON Erwan , Genta-Jouve Grégory , Gallard Jean-François , Turpin Victor , Skiredj Adam , Leblanc Karine , Beniddir Mehdi
Published: April 2020

- Context. Camellimidazoles A–C were recently reported as new natural substances arising from what was described as new caffeine degradation pathway in Keemun black tea.

- Discoveries. Under alkaline hydrolysis conditions followed by spontaneous cascade reactions with formaldehyde or dichloromethane (as the key methylene group providers), we were able to achieve the synthesis of camellimidazoles B and C. A MetWork-based pipeline was also implemented highlighting a wealth of structurally diverse compounds formed in the course of the reaction and streamlining the isolation of the newly described camellimidazoles D-F, subsequently confirmed as anticipated in silico upon extensive spectroscopic analyses. Besides demonstrating the artefactual origin of camellimidazoles, the current investigation emphasizes the fitness of MetWork-tagging to illuminate the chemical diversity associated with seemingly simple reactive conditions.

- Methods. Organic synthesis, phytochemical analysis, in silico anticipation, molecular networking dereplication
Computational Guided Drug Repurposing for Targeting 2'-O-Ribose Methyltransferase of SARS-CoV-2
Authors: Sharma Kedar , Morla Sudhir , Goyal Arun , Kumar Sachin
Published: April 2020

The recent outbreak of pandemic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led the world towards global health emergency. Currently no proper medicine or effective treatment strategies are available, therefore repurposing may play an important role in overcoming the situation. The SARS-CoV-2 genome encodes for 2-O-methyltransferase (2’OMTase) which plays a key role in methylation of viral RNA for evading host immune system. In the present study, the protein sequence of 2’OMTase of SARS-CoV-2 was analysed and its structure was modeled by comparative modeling approach and validated. The modeled structure displayed the conserved characteristic fold of class I MTase family. The library of 3000 drugs was screened against the active site of 2’OMTase. The docking analysis displayed that the active site of 2’OMTase accommodates an array of drugs which includes alkaloids, antivirals, cardiac glycosides, anticancer, steroids and other drugs. The results suggested that these drugs may be used potential inhibitors for 2’OMTase for combating the SARS-CoV-2 infection.
Anti-Corona's Drug Virtual Screening
Authors: Yousef Farah , mansour oussama
Published: April 2020

Coronavirus (COVID-19, SARS-COV-2) has become in short time a global pandemic. It causes after two weeks of exposure severe respiratory symptoms. Herbal and non-herbal drugs were tested for treatment of coronavirus. In this study, we in-silico investigated seven clinically effective drugs used to get control of the coronavirus cases. Five of them had bonds to the main core of coronavirus protease. This can interpret the clinical effectiveness of these drugs used as monotherapy or combined one and assist in discovering more effective drugs against this unseen assassin.
Synthesis of Quaternary -Amino Esters: A Remarkably Broad Substrate Scope in Aza-Friedel−Crafts Alkylation
Authors: Roche Stephane , zhao Guangkuan , Samanta Shyam , Michieletto Jessica
Published: April 2020

A versatile synthetic protocol of aza-Friedel−Crafts alkylation has been developed for the synthesis of quaternary a-amino esters. This operationally simple alkylation proceeds under ambient conditions with high efficiency, regioselectivity, and an exceptionally broad scope of arene nucleophiles. A key feature of this alkylation is the role associated with the silver(I) salt counteranions liberated during the reaction. Taking advantage of a phase-transfer counteranion/BrØnsted acid pair mechanism, a catalytic enantioselective version of the reaction is also reported.
Nanostructured Electrode Enabling Fast and Fully Reversible MnO2-to-Mn2+ Conversion in Mild Buffered Aqueous Electrolytes
Authors: Mateos Mickaël , Harris Kenneth D. , Limoges Benoit , Balland Véronique
Published: April 2020

On account of their low-cost, earth abundance, eco-sustainability, and high theoretical charge storage capacity, MnO2 cathodes have attracted a renewed interest in the development of rechargeable aqueous batteries. However, they currently suffer from limited gravimetric capacities when operating under the preferred mild aqueous conditions, which leads to lower performance as compared to similar devices operating in strongly acidic or basic conditions. Here, we demonstrate how to overcome this limitation by combining a well-defined 3D nanostructured conductive electrode, which ensures an efficient reversible MnO2-to-Mn2+ conversion reaction, with a mild acid buffered electrolyte (pH 5). A reversible gravimetric capacity of 560 mA·h·g-1 (close to the maximal theoretical capacity of 574 mA·h·g-1 estimated from the MnO2 average oxidation state of 3.86) was obtained over rates ranging from 1 to 10 A·g-1. The rate capability was also remarkable, demonstrating a capacity retention of 435 mA·h·g-1 at a rate of 110 A·g-1. These good performances have been attributed to optimal regulation of the mass transport and electronic transfer between the three process actors, i.e. the 3D conductive scaffold, the MnO2 active material filling it, and the soluble species involved in the reversible conversion reaction. Additionally, the high reversibility and cycling stability of this conversion reaction is demonstrated over 900 cycles with a Coulombic efficiency > 99.4 % at a rate of 44 A·g-1. Besides these good performances, also demonstrated in a Zn/MnO2 cell configuration, we discuss the key parameters governing the efficiency of the MnO2-to-Mn2+ conversion. Overall, the present study provides a comprehensive framework for the rational design and optimization of MnO2 cathodes involved in rechargeable mild aqueous batteries.
Manuscript-C-dots assembly at interface-041020.pdf
Authors: Zolghadr Amin Reza , Rostami Behnam
Published: April 2020

We describe a systematic investigation of carbon dots (C-dots) assemblies fabricated at the liquid/air interface because of the surface tension gradient. This gradient is originally created by capillary action and increased by addition of sodium dodecyl sulfate (SDS) surfactant or 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) phospholipid to the surface of C-dots aqueous mixture. The arrangement of carbon dots in liquid bulk phase (before self-assembly) and at the surface region (after self-assembly) was examined by TEM microscopy. The presence of SDS surfactant and POPC phospholipid at the air/water interface induced the C-dots compression. In addition, molecular dynamics simulation was conducted to obtain the structure of C-dots at liquid/vapor interface. The orientation of C-dots is evaluated quantitatively at water/vapor surface by using bivariate analysis.
Atomic-Scale Variations of Interfacial Water Structure Driven by Site-Specific Chemistry
Authors: Nakouzi Elias , Stack Andrew G , Kerisit S.N. , Legg Benjamin A , Mundy Christopher J. , Schenter Gregory K. , Chun Jaehun , De Yoreo James
Published: April 2020

Although interfacial solution structure impacts environmental, biological and technological phenomena, including colloidal stability, protein assembly, heterogeneous nucleation, and water desalination, its molecular details remain poorly understood. Here, we visualize the three-dimensional (3D) hydration structure at the boehmite(010)-water interface using fast force mapping (FFM). Using a self-consistent scheme to decouple long-range tip-sample interactions from short-range solvation forces, we obtain the solution structure with lattice resolution. The results are benchmarked against molecular dynamics simulations that explicitly include the effects of the tip with different levels of approximation and systematically account for tip size, chemistry, and confinement effects. We find four laterally structured water layers within one nanometer of the surface, with the highest water densities at sites adjacent to hydroxyl groups. The findings reveal a complex relationship between site-specific chemistry, water density, and long-range particle interactions; and represent a major step forward towards quantitative data interpretation and widespread implementation of 3D FFM.
Host-Guest Interactions on Electrode Surfaces for Immobilization of Molecular Catalysts
Authors: Sévery Laurent , Szczerbiński Jacek , Taskin Mert , Tuncay Isik , Nunes Fernanda Brandalise , Cignarella Chiara , Tocci Gabriele , Osterwalder Juerg , Zenobi Renato , Iannuzzi Marcella , Tilley David
Published: April 2020

The strategy of anchoring molecular catalysts on electrode surfaces combines the high selectivity and activity of molecular systems with the practicality of heterogeneous systems. The stability of molecular catalysts is, however, far less than that of traditional heterogeneous electrocatalysts, and therefore a method to easily replace anchored molecular catalysts that have degraded could make such electrosynthetic systems more attractive. Here, we apply a non-covalent “click” chemistry approach to reversibly bind molecular electrocatalysts to electrode surfaces via host-guest complexation with surface-anchored cyclodextrins. The host-guest interaction is remarkably strong and allows the flow of electrons between the electrode and the guest catalyst. Electrosynthesis in both organic and aqueous media was demonstrated on metal oxide electrodes, with stability on the order of hours. The catalytic surfaces can be recycled by controlled release of the guest from the host cavities and readsorption of fresh guest. This strategy represents a new approach to practical molecular-based catalytic systems.
Global Search for Structures of Carbon Crystal Under Ultrahigh Pressure
Authors: Takagi Makito , Maeda Satoshi
Published: April 2020

In this study, a systematic search for structures of carbon crystal under ultrahigh pressure was performed by using the artificial force induced reaction method including periodic boundary conditions (PBC/SC-AFIR). To perform a search under an arbitrary pressure, an algorithm to take account of pressure was implemented in the GRRM program. At 100 GPa, the search generated 710 unique structures automatically. These structures were compared with 982 structures obtained by the search under zero pressure. The structures at 100 GPa were much denser than those under zero pressure. Besides, new structures that were denser than diamond were obtained at 100 GPa.
Data-Driven Approaches Can Overcome Limitations in Multireference Diagnostics
Authors: Duan Chenru , Liu Fang , Nandy Aditya , Kulik Heather
Published: April 2020

High-throughput computational screening typically employs methods (i.e., density functional theory or DFT) that can fail to describe challenging molecules, such as those with strongly correlated electronic structure. In such cases, multireference (MR) correlated wavefunction theory (WFT) would be the appropriate choice but remains more challenging to carry out and automate than single-reference (SR) WFT or DFT. Numerous diagnostics have been proposed for identifying when MR character is likely to have an effect on the predictive power of SR calculations, but conflicting conclusions about diagnostic performance have been reached on small data sets. We compute 15 MR diagnostics, ranging from affordable DFT-based to more costly MR-WFT-based diagnostics, on a set of 3,165 equilibrium and distorted small organic molecules containing up to six heavy atoms. Conflicting MR character assignments and low pairwise linear correlations among diagnostics are also observed over this set. We evaluate the ability of existing diagnostics to predict the percent recovery of the correlation energy, %Ecorr. None of the DFT-based diagnostics are nearly as predictive of %Ecorr as the best WFT-based diagnostics. To overcome the limitation of this cost–accuracy trade-off, we develop machine learning (ML, i.e., kernel ridge regression) models to predict WFT-based diagnostics from a combination of DFT-based diagnostics and a new, size-independent 3D geometric representation. The ML-predicted diagnostics correlate as well with MR effects as their computed (i.e., with WFT) values, significantly improving over the DFT-based diagnostics on which the models were trained. These ML models thus provide a promising approach to improve upon DFT-based diagnostic accuracy while remaining suitably low cost for high-throughput screening.
Generating Ampicillin-Level Antimicrobial Peptides with Activity-Aware Generative Adversarial Networks
Authors: Tucs Andrejs , Tran Duy Phuoc , Yumoto Akiko , Ito Yoshihiro , Uzawa Takanori , Tsuda Koji
Published: April 2020

Antimicrobial peptides are a potential solution to the threat of multidrug-resistant bacterial pathogens. Recently, deep generative models including generative adversarial networks (GANs) have been shown to be capable of designing new antimicrobial peptides. Intuitively, a GAN controls the probability distribution of generated sequences to cover active peptides as much as possible. This paper presents a peptide-specialized model called PepGAN that takes the balance between covering active peptides anddodging non-active peptides. As a result, PepGAN has superior statistical fidelity with respect to physicochemical descriptors including charge, hydrophobicity and weight. Top six peptides were synthesized and one of them was confirmed to be highly antimicrobial. The minimum inhibitory concentration was 3.1μg/mL, indicating that the peptide is twice as strong as ampicillin.
Evaluation of in vitro antioxidant and anti-atherogenic properties of selected Siddha polyherbal decoctions
Authors: Perumal Rajalakshmi  , Vellingiri Vadivel  , Sridharan Sriram  , Pemaiah Brindha
Published: April 2020

This research work explains the antioxidant and anti-atherogenic effects of selected Siddha polyherbal decoctionssuch as Nilavembukudineer, Kabasurakudineer, NotchikudineerandAdathodaikudineer. Even though all the above decoctions have been used for fever, cold, cough, bronchitis, dysphonea and body pain in Siddha system of medicine, their antioxidant and anti-atherogenic properties were notinvestigated scientifically.We have analyzed the polyphenolic content, antioxidant and anti-atherogenic properties of decoction of the above-mentioned herbal formulations. The toxicity of the decoctions was also performed in PMBC.Inthe investigated formulations, Notchikudineershowed higher level of total phenolic content (560 mg GAE/100 g), followed byAdathodaikudineer (260 mg GAE/100 g),Nilavembukudineer(150 mg GAE/100 g) and Kabasurakudineer(90 mg GAE/100 g). Similarly, Notchikudineer exhibited strong antioxidant activity in terms of radical scavenging potential against DPPH (IC-50: 2.12 mg/L), followed the Adathodaikudineer (IC-50: 2.27 mg/L),Nilavembukudineer(IC-50: 4.48 mg/L) and Kabasurakudineer (IC-50: 9.29 mg/L).In toxicological study all the decoctions of selected formulations didn’t show any toxicity.Similarly, Nilavembukudineer showed maximum inhibition of lipid peroxidation when compared to other herbal decoctions. Among the investigated Siddha formulations, Nilavembukudineer was found to possess high antioxidant and anti-atherogenic potentials and hence it could be further investigated as anti-atherogenic drug using in vivo model.
Role of insulin/insulin-like growth factor-1 signaling pathway genes on the lifespan of Caenorhabditis elegans
Authors: Siti Bazilah Zulkefli  , Ahmad Nazrun Shuid  , Goon Jo Aan
Published: April 2020

Aging process is influenced by the insulin/insulin-like growth factor-1 signaling (IIS) pathway or IGF-1 signaling pathway. Studies done on the genes of this pathway were found to affect longevity. However, no conclusive results have been drawn.The purpose of this systematic review is to summarize the function of genes involved in the IIS pathway of Caenorhabditis Elegans (C. elegans), a nematode commonly used as a model organism in molecular genetics and developmental biology. A literature search for relevant studies was done through PubMed and Scopus databases using MeSH keywords Caenorhabditis elegans, C. elegans, nematode, genes, RNA, DNA, IIS pathway, IGF pathway, lifespan, and longevity. The search was limited to studies that were published in the last ten years (2008-May 2018). After exclusion of duplicates, review papers, human, in vitro, and other organismal studies, a total of 76 research articles were selected for further assessments. Data relevant to the effects of IIS genes on the lifespan ofC. eleganswas independently extracted. Reduction of daf-2 and age-1 and overexpression of sir-2.1 were reported to promote increment of the lifespan of C. elegans.  Furthermore, differentially expressed genes that were involved in the protection against oxidative stress, pathogen attack, and toxicity includeins-18, numr-1/-2, sgk-1, and rgs-1. The knockdown of daf-2, age-1, and overexpression of sir-2.1 genes prolonged the lifespan of C. elegans while knockdown of daf-16, hsf-1, sir-2.1 as well as skn-1 shorten the lifespan of C. elegans.In conclusion, the differential expression of genes in the IIS pathway prolongs the lifespan of C. elegans.
东部断陷盆地领域地震采集方法总结及建议
Authors: 孙 得福
Published: April 2020

东部断陷盆地领域属于油气开发老区，是主要的产能阵地，通过近期东部断陷盆地地震勘探项目的地震采集方法进行总结分析，找出存在问题与不足，针对存在的问题与不足，提出具有建设性的方案 - 垂直叠加采集，有效地解决目前存在的方位角和分辨率的问题，在不增加资金投入的情况下，使资料品质（空间分辨率和方位角等方面）得到提高，提高复杂断块和岩性油气藏的识别精度。
浅谈建筑与路桥的组合设计
Authors: 肖 瀚
Published: April 2020

目前，常规的路桥与建筑设计主要是考虑二者之间的距离关系，包括征地用地范围、采光、噪声等因素。而关于路桥与建筑的组合设计并不常见，论文以实际工程的案例进行分析，从设计和施工角度提出一些见解，希望起到抛砖引玉的作用。
FSC赛车车架的结构分析与轻量化设计
Authors: 戴 波棋 , 李 长江
Published: April 2020

论文以 FSC 赛车车架作为研究对象，主要研究 FSC 赛车车架静力学及模态分析以及基于灵敏度分析的轻量化设计。车架的有限元模型使用 HyperMesh 进行处理，通过对车架有限元赋予 4 种工况特性，分析车架的强度和刚度。车架的轻量化设计以管件壁厚为设计变量，以 1 阶模态频率和质量的相对灵敏度系数为变量筛选条件，以加载点位移、车架 1 阶模态频率为约束条件，以质量最小为目标函数，进行轻量化优化，最终实现车架减重 4.6Kg。
高压输电线路综合防雷措施的研究与应用
Authors: 马 顺超
Published: April 2020

随着近几年来社会经济的持续发展，用电量需求不断加大，这对用电安全性及供电系统的稳定性提出了更高的要求。作为供电系统的关键环节，高压输电线路运行的效率进行的质量直接关系着供电的水平。因此，必须要加强对该输电线路的研究。雷击事故一直以来是影响高压输电线路运行稳定性安全性的重要因素。论文主要针对高压输电线路综合防雷措施的研究与应用进行探究，希望能够通过合理的方法和科学的策略减少雷击事故，保证输电线路运行的高效性和稳定性。
目标成本管理在公路工程施工项目中的应用
Authors: 杨 智慧
Published: April 2020

目标成本管理是对施工企业的低消耗和低成本进行的评估，论文结合多年的公路建设项目管理经验，分析了如何开展公路建设项目成本管理工作，并针对成本控制过程提出相应建议。成本管理可以有效地控制公路建设项目的经济优势，但是成本管理的前提是质量控制，而公路建设的主要要求应该是质量控制。
浅析建筑室内外空间设计方案
Authors: 胡 平
Published: April 2020

随着社会经济的不断发展和人们生活水平的逐渐提升，人们对建筑室内外空间设计的要求越来越高。传统的设计方法以及设计理念已经无法满足人们日益增长的文化需求，需要结合当前时代发展的背景以及人们的审美特征，开展创新性的室内设计和室外设计。论文主要针对建筑室内外空间设计方案的制定以及应用进行探究，希望能为建筑行业的可持续发展提供一定的参考。
关于地质矿产勘探深部的找矿途径思考
Authors: 张 俞
Published: April 2020

与浅层矿产相比，深部矿产品质更好，品位更高，市场前景更为广阔。结合当前中国矿产市场发展趋势来看，开发深部矿产资源将成为未来的一项重要工作。基于此，论文联系实际，主要就地质矿产勘探深部的找矿途径展开探究，希望能为相关工作的开展带来些许帮助。
新时期非金属地质矿产勘查工作手段和方法研究
Authors: 覃 晓燕
Published: April 2020

随着社会与经济的发展，非金属地质矿产勘查工作迎来了新的机遇与挑战。只有对现有的勘查工作手段和方法进行深入的分析与优化，才能够有效提升非金属地质矿产勘查的精度，保证非金属地质矿产勘查工作的效率。基于此，论文重点针对新时期非金属地质矿产勘查工作手段和方法进行了详细的分析，以供参考。
简述景观评论标准的构成要素
Authors: 吴 伟勇
Published: April 2020

在中国城市景观建设规模和程度日益扩大的今天，景观评论和批评的介入，使景观不仅从实践上得以自省，也为景观理论和学科的发展提供重要的补充。中国现代景观评论目前正处在觉醒和发展阶段，景观评论引起了越来越多的关注，而且开展景观评论的途径也在不断的增多，影响逐渐在扩大，尤其值得关注的是网络媒体、自媒体的兴起，提供了一个新的评论传播平台。同时，景观理论研究的专家学者也在积极地呼吁、探索和构建评论的标准。论文从景观中功能与美学上的本体讨论，社会和文化层面、景观技术、环境生态和可持续发展四个层面，尝试探索景观评论标准的基本构成要素，从而对景观实践或者景观案例提供一个评论及评价的一种参考。
关于BIM技术在建筑工程管理中的应用
Authors: 张 贞
Published: April 2020

随着中国经济实力的不断提高，城镇化建设发展迅速。与此同时，建筑行业也得到了空前发展，传统的工程管理模式已经无法适应现代化建筑行业的发展需求。BIM 技术是一种新兴的建筑设计方法，与传统的二维图纸不同，BIM 技术体现出了更多的优势，能够对建筑工程进行全方位的管理，提高建筑工程管理质量和效率，从而有效保证建筑的质量安全。论文对 BIM 技术在建筑工程管理中的应用进行了分析，并针对一些应用过程中存在的问题，提出了一些完善的策略，希望能够为提升 BIM技术在建筑工程管理中的应用水平提供一些参考性的建议。
水环境监测质量控制相关措施的探讨
Authors: 黄 志刚
Published: April 2020

经济的迅速发展对水资源的要求非常高，而现阶段水资源需求也呈现出不断上涨的趋势。但从现阶段各个行业对水资源的利用状况来说，污水排放造成非常严重的水质污染，水资源质量呈现出明显下降趋势，对水环境进行有效监测非常重要的，能够更为有效控制整体水环境质量。为了更好保证水环境监测结果的准确度，保护水资源需要不断解决其中的问题并提出相对应的解决措施。
浅析工程地质勘察中水文地质问题的危害性
Authors: 罗 善煌
Published: April 2020

得益于中国综合实力的提升，建筑工程质量与安全俨然成为人们关注重点。地质勘察作为建筑工程建设中的重要组成，水文地质勘察可以帮助企业在工程建设前期阶段掌握施工现场水文地质条件。若水文地质条件较差，会直接影响到建筑工程整体质量与安全性。所以，探究分析工程地质勘察中水文地质问题的危害性有着至关重要的作用和影响。
承压设备常用无损检测仪器设备的检定、校准和核查
Authors: 赵 阳 , 张 元鹏 , 杨 鹏
Published: April 2020

随着中国科学技术的不断发展，无损检测行业也迎来了飞速发展的契机。尤其是在承压设备制造安装等领域，无损检测显得甚为重要。检测机构与检测人员从事的检测工作，全都是与质量安全相关的、需要出具公正性检测数据和（或）检测结果的工作，因此必须保证其检测数据的准确性和检测结果的可靠性。而无损检测数据和检测结果 90% 以上要依靠于各种检测设备，因此必须保证检测设备的量值准确与能力范围。论文主要讨论承压设备常用的无损检测设备的检定、校准和核查的相关要求，确保无损检测工作所使用的检测设备处于可靠状态，为检测数据与检测结果提供有力保障。
3S技术在自然资源工程中的应用
Authors: 尤 洪粉
Published: April 2020

随着科学技术的不断发展和现代化信息时代的全面到来，现代网络技术的应用极大地促进了各行各业的发展。作为现代信息技术的关键组成部分， 3S 技术广泛应用于自然资源工程项目建设以及保护过程中，能够有效提升自然资源工程项目的效率和质量。论文主要针对 3S 技术的相关概念进行表述，并分析了 3S 技术在自然资源工程中的有效应用和相关应用优势，希望能为 3S 技术的持续稳定发展提供一定的参考。
BIM虚拟仿真技术在建筑工程施工技术教学中的实践
Authors: 肖 应祺
Published: April 2020

随着中国建筑行业的快速发展，为适应建筑行业对人才的需求，各大院校都单独设立了建筑工程施工技术专业。为了帮助学生更直观地掌握建筑工程施工技术，很多高校纷纷引进 BIM 虚拟仿真技术，通过仿真模拟建筑施工现场环境，让学生更加扎实的把握技术要领。论文结合 BIM 虚拟仿真技术的相关理论知识，对其在建筑工程施工技术教学中的实践情况进行了分析。
电气自动化技术在电力工程中的应用
Authors: 王 婧婷
Published: April 2020

在现代化经济以及社会发展过程中，社会生产在很大程度上需要依靠电力工程，而电力工程生产能力的提升需要借助于现代化的自动技术，通过运用电气自动化技术有效提升电力工程整体水平和整体的生产效率。如何进一步推动电气自动化技术在更多领域的运用并不断改进现有技术对电力企业非常重要，论文主要对电气自动化技术特点、作用及其在电力工程中的应用进行了分析，旨在促进其作用得到有效的发挥。
机械设计制造技术的应用研究
Authors: 郭 建同
Published: April 2020

机械设计制造技术是中国工业产业发展的重要基础，对于中国社会经济体系构建与发展也有着重要的影响意义。在机械设计与制造技术的应用中，要加强对新时期各种时代技术的融入，推动机械设计制造技术的应用发展。论文对现阶段机械设计与改造的现状进行分析，并提出现阶段机械设计制造技术的应用发展方向，以推动中国机械设计制造技术发展。
Capparis spinosa’nın yara iyileşmesi üzerindeki etkisi: Sıçanlarda klinik ve histomorfometrik bir çalışma
Authors: OZDEMİR Hakan , ŞEKER Başak
Published: April 2020

Amaç: Capparis spinosa (C. Spinosa) antioksidan, antienﬂamatuar, antialerjik, antiviral ve antikanserojenik özelliği gösteren ﬂavanoit molekülü içerir. Bu çalışmanın amacı sıçanlarda palatinal bölgede oluşturulan yara modelinde C. spinosanın yara iyileşmesi üzerindeki etkisinin değerlendirilmesidir. Yöntem: Çalışmada 60 adet erkek Wistar sıçan kullanıldı. Başlangıçta iyileşme referansı olarak (0 gün) altı hayvan sakriﬁye edildi. Sıçanlar C. spinosa, Klorheksidin (Klx) ve Kontrol (K) grubu olarak üç gruba ayrıldı. Tüm gruptaki denekler rastgele seçilerek altışar sıçandan oluşan dokuz alt grup oluşturuldu. Anestezi altına sıçanların damaklarının tam ortasında punch ile 3 mm çapında sirküler eksizyonel yara yüzeyleri oluşturuldu. Mukoperiosteal kısım keskin diseksiyonla uzaklaştırıldı ve açık kemik yüzeyindeki alan sekonder iyileşmeye bırakıldı. C. Spinosa, 1 ml/gün olacak şeklide gavaj yoluyla lokal olarak uygulandı. Sıçanlar yedinci, 14. ve 21. günlerde sakriﬁye edildi ve yara bölgesinin fotoğraﬂarı çekildi. Her bir fotoğraf özel bir programa aktarılarak defekt bölgesindeki yara alanı ölçüldü. Histolojik kesitler alınarak enﬂamatuar hücre varlığı, epitelizasyon ve iyileşme düzeylerine bakıldı. Bulgular: Epitelyal marjinler arasındaki ortalama yara alanı, tüm gruplarda zamanla önemli ölçüde azaldı (p <0.05). C. Spinosa grubu, Klx ve K grubu ile karşılaştırıldığında yedi, 14 ve 21. günlerde (sırasıyla 6.43±0.65; 3.87±0.50; 0.94±0.39) belirgin bir yara alanı azalması gözlemlenmiştir. 21. günde, kontrol grubunda hala enﬂamatuar hücreler gözlenmiştir. Sonuç: Çalışmanın bulguları ışığında C. Spinosa yara iyileşmesini hızlandırarak yumuşak dokunun iyileşmesinde olumlu etkileri gözlenmiştir.
Eficácia anti-helmíntica e desempenho em rebanho de matrizes ovinas na mesorregião leste do Rio Grande do Norte
Authors: Roberto Francisca Fernanda Silva , Difante Gelson Santos , Gurgel Antonio Leandro Chaves , Zaros Lilian Gioto , Medeiros Henrique Rocha , Vieira Luiz Silva
Published: April 2020

Objetivou-se avaliar a eficácia anti-helmíntica em rebanhos de matrizes ovinas na mesorregião leste do Rio Grande do Norte. Os animais foram distribuídos em cinco grupos com 12 ovelhas cada, sendo estes: cloridrato de levamisol (5mg/kg), closantel (10mg/kg), moxidectina (0,2mg/kg) e ivermectina (0,2mg/kg) e o grupo controle sem tratamento anti-helmíntico. Foram avaliadas as seguintes variáveis no dia zero e a cada sete dias após a administração dos anti-helmínticos: contagens de ovos por grama de fezes (OPG), calculado o percentual de eficácia, peso, ganho de peso, escore de condição corporal, e o grau de anemia. Observou-se diferença significativa na OPG dos animais, onde as maiores médias foram observadas no grupo tratado com ivermectina (7858,3±6880).  A ivermectina (34,7%) apresentou-se com baixa eficácia anti-helmíntica em relação a moxidectina (93,3%), closantel (89,1%) e ao levamisol (89,4%). O peso final dos animais não foi alterado pelo uso dos anti-helmínticos, com média de 39,5 kg. As matrizes tratadas com ivermectina, levamisol e o grupo controle, apresentaram-se com o escore de condição corporal concentrados nos graus 2,5 e 3. Os graus de anemia ficaram dispostos entre 2 e 4, sendo que o grupo medicado com a ivermectina foi o que apresentou animais com uma maior dispersão nesse intervalo. A moxidectina mostrou-se eficiente na redução de nematoides gastrintestinais no rebanho estudado e pode ser indicado no controle desses parasitos.
Staphylococcus aureus enterotoxigênicos em leite de cabra e seus derivados, um risco à Saúde Pública
Authors: Aragão Breno Bezerra , Trajano Sabrina Cândido , Mota Rinaldo Aparecido
Published: April 2020

A caprinocultura leiteira é considerada como uma das principais atividades agropecuárias da região Nordeste, sendo uma importante fonte de geração de renda e de empregos. Entretanto é uma atividade de baixa tecnificação, fato preocupante para a saúde pública, visto que o leite caprino e seus derivados podem ser importantes veiculadores de microrganismos causadores de Doenças Transmitidas por Alimentos. Dentre os microrganismos destaca-se o Staphylococcus aureus, agente infeccioso responsável por casos de intoxicação alimentar envolvendo o leite caprino e seus derivados. Apesar da importância, estudos sobre sua qualidade microbiológica ainda são escassos, sendo esta revisão um alerta quanto à necessidade de avaliação microbiológica do leite caprino e derivados comercializados no Nordeste brasileiro.
Gestão zootécnica e genética informatizadas em pequenos ruminantes: uma revisão
Authors: Borges Laylson Silva , Rocha Fernanda Samara Barbosa , Neri Vanessa Santos , Maia Flora Suzane Parente , Castro Otávio Cury Costa , Campelo José Elivalto Guimarães , Sarmento José Lindenberg Rocha
Published: April 2020

A criação de pequenos ruminantes tem se expandido em todos os estados brasileiros e, independentemente do objetivo da exploração, tem muito a contribuir para o desenvolvimento socioeconômico do país. Entretanto, esse setor enfrenta constantes desafios, como, por exemplo, a falta de informações e acesso às tecnologias, sendo a ausência de informatização uma das principais limitações para o registro de dados no campo. Dessa forma, objetivou-se, com esta revisão da literatura, compilar informações a respeito da utilização de ferramentas informatizadas aplicadas aos controles zootécnico e genético e à seleção de acasalamentos em pequenos ruminantes. Constatou-se que a adoção dessas ferramentas na ovinocultura e caprinocultura ainda é bastante limitada.
My Narrative is Not What You Think It Is: Experiences of African Americans in a Doctor of Education Program
Authors: Davis Shametrice , Reese Leslie , S Griswold Cecelia
Published: April 2020

Aim/Purpose: This paper examines the experiences of African American students in a doctor of education program at a comprehensive university in Southern California.

Background: Qualitative case study methodology and critical race theory is used to highlight asset rather than deficit narratives of the participants, illuminating another aspect of commonly understood experiences for underrepresented students in education.

Methodology: Qualitative case study methodology was used for a sample of 14 African American doctoral students in the Southern California area. Critical race theory provided a framework through which to support data analysis and subsequent findings.

Contribution: The original contribution of this paper is the asset-narrative of African American doctoral students at an institution that is not research-driven.

Findings: Findings assert that (1) asset narratives of African American students need to be highlighted, (2) action-research as an option for dissertation completion is important for Ed.D. programs, and (3) racial identity of African Americans is complex, therefore broader understandings of black identity are needed, and must be coupled with anti-deficit ideology.

Recommendations for Practitioners: Recommendations for practitioners include expanding understandings of African American identity coupled with anti-deficit ideology to enhance student interactions with both faculty and peers throughout doctoral education.

Recommendation for Researchers: It is suggested that future research continue to focus on doctoral student experiences in institutions that are not research intensive.

Impact on Society: This research provides an original contribution by furthering understandings of the complexity of the African American experience with identity, research, and doctoral education experiences.

Future Research: Future research should focus on other underrepresented populations in doctoral education at universities that are not research-intensive.
RESPOSTA DE SORGO INOCULADO COM Azospirillum brasilense A DOSES DE NITROGÊNIO EM COBERTURA
Authors: Mortate Roberto Kennedy , Nunes Bruno de Moraes , Costa Estevam Matheus , Rocha Eleusa Maria Ferreira , Ventura Matheus Vinicius Abadia , Pereira Leandro Spíndola
Published: April 2020

Estirpes de Azospirillum brasilense conseguem fornecer parte do nitrogênio que as gramíneas necessitam. Objetivou-se avaliar o efeito combinado da inoculação de A. brasilense e nitrogênio sobre as características agronômicas do sorgo granífero e a população de bactérias diazotrópicas nas raízes. O trabalho foi composto por duas etapas: 1- Ensaio a campo: T1= 200 Kg.ha-1 de ureia (U), T2= 300 mL ha-1 de inoculante + 50 Kg ha-1 de U, T3=300 mL ha-1 + 100 Kg ha-1 de U, T4=300 mL ha-1 +150 Kg ha-1 de U e T5=300 mL ha-1+ 200 Kg ha-1 de U, avaliando caracteres morfológicos e componentes de produção; 2- Ensaio em casa de vegetação: T1= 300 mL ha-1 de MG, T2= 300 mL ha-1 de inoculante + 50 Kg ha-1 de U, T3=300 mL ha-1 + 100 Kg ha-1 de U, T4= 300mL ha-1 +150 Kg ha-1 de U e T5= 300mL ha-1+ 200 Kg ha-1 de U, avaliando clorofila total, comprimento radicular e população de bactérias. Nos caracteres morfológicos, fisiológicos e componentes de produção, os tratamentos que receberam 150 e 200 Kg de ureia ha-1 combinado com inoculação foram superiores aos demais, no entanto, em casa de vegetação o tratamento com 200 kg de ureia ha-1 inibiu a proliferação das bactérias diazotróficas. Houve incrementos na produtividade do sorgo granífero quando utilizada inoculação, sendo possível a redução da adubação nitrogenada em 25% com a utilização de inoculação.
POST-HARVEST CONSERVATION OF “PIONEIRA” BANANA (Musa spp.) USING BABAÇU COCONUT OIL
Authors: Veras Fernando Henrique Cardoso , Carvalho Fredson Leal de Castro , Barbosa Júnior Lindomar Braz , Sousa Rayane Reis , Arouche Railton Reis , Abreu Edvan Carlos de , Lobo Roberta Freitas de Souza
Published: April 2020

The use of fruit coatings allows maintaining longer post-harvest quality of fruits, preserving their physicochemical characteristics (appearance, taste and texture) and increasing commercial acceptance. Thus, this work aimed to evaluate the effect of the application of babassu coconut oil as coating on ‘Pioneer’ banana (Musa AAAB) to preserve its quality characteristics and increase shelf life. The experiment was carried out at the Laboratory of soils of the Federal Institute of Tocantins, Araguatins - TO. Completely randomized design was adopted in a 6 x 5 factorial scheme (six purified babassu coconut oil concentrations as vegetal coating, T1 - 0.0%, T2 - 1.0%, T3 - 2.0%, T4 - 3.0%, T5 - 4.0%, T6 - 5.0% and five evaluation times, 1st, 3rd, 6th and 9th and 12th days after coating application), with four replicates. Products were applied to fruits by dipping, naturally dried and stored at room condition for 12 days. Variables evaluated were peel colour, total solids, pH, fresh mass loss. Data were submitted to normality and homogeneity tests, fulfilling the assumptions, analysis of variance was performed, with significance measured by the F test (p <0.05). Due to the quantitative variation sources (oil concentrations and evaluation times), regression analyzes were performed for all variables except for score scale method. Regarding fruit peel colour, babassu coconut oil had relevant effect, and treatment with 5% babassu oil concentration was the one that kept green peel colour longer than the other treatments. According to results obtained, the use of babassu coconut oil in post-harvest conservation of ‘Pioneer’ banana had significant effects, since all treatments with babassu oil concentrations showed efficiency in inducing delayed ripening, especially providing delayed increase in °Brix content of fruits.
INTERFERÊNCIA DE PLANTAS DANINHAS NA CULTURA DA CANOLA (Brassica napus L.)
Authors: Nichelati Flávia Dacol , Bottega Eduardo Leonel , Guerra Naiara , Fioreze Samuel Luiz , Oliveira Neto Antonio Mendes de , Oliveira Zanandra Boff de
Published: April 2020

Um dos principais problemas para o cultivo da canola no Brasil são as plantas daninhas, pois não há no mercado nacional herbicidas registrados que sejam seletivos para a canola em pós emergência, como também não há informações sobre o período de interferência das plantas daninhas nesta cultura. Objetivou-se com este estudo determinar os períodos de interferência de plantas daninhas na cultura da canola. O delineamento experimental utilizado foi o de parcelas subdivididas, onde as parcelas representaram os modelos de interferência (controle e convívio) e as subparcelas oito períodos de interferência. Para a remoção das plantas daninhas foram realizadas capinas manuais. Efetuou-se a coleta de 10 plantas das linhas centrais de cada parcela para a avaliação dos parâmetros biométricos e produtivos, os quais foram: altura de plantas; diâmetro de caule e número de síliquas. Não foi observada influência dos modelos de interferência e dos períodos sobre a altura de plantas, tampouco da interação destes fatores de variação. A convivência com plantas daninhas afeta negativamente o diâmetro de caule e o número de síliquas das plantas de canola. Não foi possível determinar a produtividade da cultura. Para o número de síliquas, foi observado Período Anterior a Interferência (PAI) de 8 DAE, Período Total de Prevenção a Interferência (PTPI) de 23 DAE e Período Crítico de Prevenção a Interferência (PCPI) de 15 DAE.
EFEITO DA DESFOLHA NA ALTURA DE PLANTAS E PRODUTIVIDADE DE GRÃOS DE CANOLA (Brassica napus L.)
Authors: Dos Santos Cadmo João Onofre Gregory , Da Rocha Leidiana , Heldwein Arno Bernardo , Durigon Angelica , Nied Astor Henrique , Milanese Bruno Octavio
Published: April 2020

A redução da área foliar das plantas interfere no potencial fotossintético e ocasiona perdas significativas no potencial de rendimento de grãos das culturas agrícolas. O objetivo desse trabalho foi avaliar o efeito da desfolha total na altura de plantas e produtividade final de grãos de canola em solo que apresenta má drenagem natural. Foi utilizado o delineamento inteiramente casualizado, com parcelas de 0,4 m de largura x 1 m de comprimento sub-subdivididas (trifatorial 2 x 4 x 4, onde fator A = solo com e sem drenagem artificial na parcela principal; fator C = cultivares Hyola 433, Hyola 76, Diamond e Alht B4 na subparcela, e fator D = desfolha total no início, pleno e final da floração na subsubparcela), com duas repetições cada tratamento. A desfolha foi realizada em 1 m linear na fileira central de cada subparcela e a altura medida em 4 plantas de cada parcela. As variáveis passaram por análise de variância (5% de probabilidade de erro) e os resultados significativos foram comparados pelo teste de Skott-Knott. Não houve interação tripla significativa tanto para a altura de plantas quanto para produtividade. Houve diferença significativa de altura de plantas entre os tratamentos com e sem drenagem sob as diferentes épocas de desfolha e entre as cultivares utilizadas. As cultivares Hyola 433 e Diamond apresentaram alturas constantes em diferentes épocas de desfolha. A produtividade é afetada significativamente pelo fator drenagem, apresentando maiores valores no solo com drenagem. Todas as cultivares apresentaram baixa produtividade quando realizada a desfolha no início da floração.
SILVER NANOPARTICLES AND RESISTANCE INDUCERS IN THE CONTROL OF BANANA ANTHRACNOSIS
Authors: Witter Ana Paula Werkhausen , Carvalho Joice Salla , Lunardi Leandro , Espindola Bruno Pansera , Nohatto Marcos André , Gomes Patrícia Alcântara , Vasconcellos Fernanda Correa da Silva , Da Rosa Eliete de Fatima Ferreira
Published: April 2020

The search for techniques to control anthracnose (Colletotrichum musae) of lower toxicity to human health and environmental impact is essential for the development of a sustainable system in the banana production chain. Among these strategies, with great potential for use in agriculture and still lacking efficiency studies, silver nanoparticles (AgNPs) and resistance inducers stand out. Thus, the aim of this work was to evaluate the in vitro antifungal activity of AgNPs and resistance inducers in the control of post-harvest banana anthracnose. In in vitro experiment, the fungus was cultured in PDA culture medium added of different AgNP concentrations (0, 25, 50, 100 and 200 ppm) and resistance inducers (Bacillus subtilis, acibenzolar-S-methyl and Saccharomyces cerevisiae). The variable analyzed was mycelial growth inhibition (%), while in the post-harvest experiment, banana fruits were immersed for three minutes using the same treatments as the in vitro study. In this case, incidence (% of fruits with lesions) and severity (% of epidermis covered by lesions) were evaluated. Colloidal silver concentration at 100 ppm, as well as the resistance of Bacillus subtilis and acibenzolar-S-methyl inducers were the most efficient treatments in the control of post-harvest banana anthracnose caused by Colletotrichum musae.
UTILIZAÇÃO DE CONCHAS DE SURURU COMO FONTE ALTERNATIVA DE CÁLCIO PARA CODORNAS JAPONESAS
Authors: Lana Sandra Roseli Valerio , Lana Geraldo Roberto Quintão , Barros Júnior Romilton Ferreira , Silva Maria Pollyane Lima , Santos Daniel Silva , Leão Ana Patricia Alves
Published: April 2020

Objetivou-se avaliar a influência da utilização de conchas de sururu (CS) na alimentação de codornas japonesas sobre o desempenho produtivo e viabilidade econômica durante o período de um a 35 dias de idade. Foram utilizadas 360 codornas japonesas alojadas em gaiolas do tipo bateria de arame galvanizado. O delineamento experimental utilizado foi o inteiramente casualizado, com seis tratamentos e seis repetições, com 10 aves por unidade experimental. Os tratamentos foram: T1 - Ração basal com 0,90% de cálcio, oriundo do calcário calcítico; T2 – Ração basal com redução de 20% de cálcio oriundo da CS fornecendo 0,72% de cálcio; T3 – Ração basal com redução de 10% de cálcio oriundo da CS fornecendo 0,81% de cálcio; T4 - Ração basal com aumento de 10% de cálcio oriundo da CS fornecendo 0,99% de cálcio; T5 - Ração basal com aumento de 20% de cálcio oriundo da CS fornecendo 1,08% de cálcio e T6 – Ração basal contendo 0,90% de cálcio oriundo da CS. As variáveis de desempenho avaliadas foram: ganho de peso, consumo de ração e conversão alimentar. Houve diferença significativa (p<0,05) para consumo de ração das codornas no período de um a 35 dias de idade, sendo o T3 (0,81% de cálcio oriundo CS) apresentando o melhor resultado, bem como para viabilidade econômica. A farinha de conchas de sururu pode ser utilizada em até 100% de substituição ao calcário calcítico nas rações de codornas japonesas de um a 35 dias de idade, sem afetar o desempenho das aves, além disso, permite reduzir o nível de cálcio das rações para 0,81%.
EFEITOS DA INTERCEPTAÇÃO LUMINOSA OU PERÍODO DE DESCANSO FIXO NO ACÚMULO DE FORRAGEM E ESTRUTURA DO DOSSEL DE UMA ANTIGA CULTIVAR DE Megathyrsus maximus
Authors: Amorim Philipe Lima , Lopes Erica Laura Guilherme , Moreira Andressa Mirielle , Cavalcante Filipe Souza , Lyra Guilherme Bastos , Filho José Teodorico Araújo , Santos Ana Iris Silva , Sousa Braulio Maia Lana
Published: April 2020

Objetivou-se com esse trabalho avaliar os efeitos frequência de colheita de pastos de Megathyrsus maximus cv. sempre-verde na estrutura, dinâmica do perfilhamento, período de descanso e ciclos de colheita. Foram avaliados três tratamentos, caracterizados por frequências de colheita, sendo elas: a de períodos fixos de 28 dias, sempre que dossel interceptasse 90% ou 95% da luz incidente, seguindo delineamento inteiramente casualizado com quatro repetições. Houve efeito das frequências de colheita na altura do dossel, índice de área foliar e interceptação luminosa tanto na pré-colheita quanto pós-colheita. A taxa de aparecimento de perfilhos foi maior nos pastos manejados a 90% de interceptação luminosa do que quando manejados a períodos fixos de 28 dias. Efeito inverso foi observado na taxa de sobrevivência de perfilhos, em que os pastos manejados a períodos de 28 dias apresentaram maior média do que aqueles a 90% de interceptação luminosa. Maior número de ciclos de colheita e menor período de descanso foram observados na frequência de 90% de interceptação luminosa e menores no período fixo de descanso. Não houve influência das frequências na massa de forragem, porcentagem de colmo vivo, forragem morta, acúmulo de forragem e taxa de acúmulo de forragem. Observou-se efeito das frequências apenas na porcentagem de lâminas foliares, em que a frequência de 90% de interceptação luminosa apresentou o maior valor médio. A correlação entre a interceptação luminosa ou índice de área foliar com a altura do dossel apresentou-se forte e positiva. A utilização da frequência de colheita variável é mais efetiva em controlar a estrutura do dossel que a fixa, além de proporcionar foragem de composição morfológica mais adequada ao consumo animal e perfil mais jovem da população de perfilhos. O capim sempre-verde pode ter sua rebrotação interrompida quando o dossel atingir entre 80-85 cm de altura e o pastejo encerrado quando atingir 50 cm.
A Systematic Literature Review Method On AES Algorithm for Data Sharing Encryption On Cloud Computing
Authors: Hidayat Taufik , Mahardiko Rahutomo
Published: April 2020

Cloud computing is one revolution in information technology (IT) that can share resources, services and data through a network among users. Because users have same rights on the network to transfer data, data are vulnerable to be attacked by unauthorized person. Lately, data security in a system only concentrates on data storage on cloud by utilizing internet security, but a little concentration is found during data transfer. By considering security as a serious problem, an encryption-based proposed system is presented to secure during data transfer. Authors propose an approach to boost system security during data transfer in order to prevent data theft by unauthorized person. To prevent an attack by unauthorized person, Advanced Encryption Standard (AES) will be proposed to secure data transfer and storage in cloud computing. For better future, authors will propose Systematic Literature Review (SLR) to generate suggestions and opportunities in AES cloud computing.
A STUDY OF ACADEMIC FACULTY SATISFACTION OF ERESOURCES AND SERVICE IN UNIVERSITY AND FISHERY SCIENCE LIBRARIES
Authors: O Maranna
Published: April 2020

This is a study on electronic information and information seeking behaviour of Marine science faculty. This study is based on empirical data collected through questionnaire and from an online survey conducted between January 2010 to March 2010 at south Indian Marine science departments and Libraries. The goal of this study is to investigate how this faculty uses the e-resources in our institutional resources and also studied need and satisfaction levels of various information sources and to obtain insights into informationseeking behaviour, especially its similarities and differences compared with the informationlocating patterns used by their marine science and fishery College Libraries.
Potential of Lactobacillus casei shirota’s strain against the biofilm-forming of Salmonella Spp
Authors: Fauziah Annisa Rizka , Bahar Meiska , Ayu Wulandari Aprilla
Published: April 2020

Biofilm of Salmonella spp. is formed through the expression of biofilm genes associated with proteins (bapA) regulated by curli synthesis genes (csg) which carry out adhesion, colonization, maturation, and dispersion on the surface of the intestinal epithelium. This study aimed to determine the antibiofilm activity of Lactobacillus casei Shirota’S strain (LcS) as an inhibitor of Salmonella spp. biofilm formation in vitro. This research was a true experimental study using Microtiter Plate 96 wells Biofilm Assay method. The sample used was the suspension of Salmonella spp. The treatment was in the form of adding a LcS suspension with a concentration series of 10-1;10-2; 10-3;10-4; and 10-5. Biofilm measurements were carried out using a microplate reader and obtained quantitative data in the form of Optical Density at a wavelength of 595nm. The results of this study showed that LcS suspension has antibiofilm activity ranging from 10-5 concentrations with a percentage of 36.58% (p<0.05). The results of exometabolism LcS can reduce Salmonella growth. Exopolysaccharide (EPS) and sortase-dependent proteins (SrtA) of LcS form barriers as competitive adhesion in inhibiting pathogenic biofilm formation.
The potency of bay leaves extract (Syzygiumpolyanthum) as anti-inflammation in Rattus norvegicus induced with Complete Freund’s Adjuvant
Authors: Buana Dwi Candra , Sudiana I Ketut , Nugraha Jusak
Published: April 2020

The using of herbal plants in Indonesia as medicine based on traditional knowledge. One of the herbal plants that believed has medication effect is bay leaves (Syzygiumpolyanthum). Bay leaves contain a flavonoid that can prevent inflammation. The study aims to prove the potency of bay leaves extract to prevent the inflammation, which is indicated by decreasing the paw edema thickness in rat induced with Complete Freund's Adjuvant (CFA). This study used 25 animal models of male rat (Rattus norvegicus) strain Wistar that divided into five groups, one group for a normal group (no treatment), one group for positive control which was injected with CFA sub plantar and given treatment with Na CMC and three test groups which is got three different doses of bay leaves extract peroral and the doses were 100 mg/kg BW, 300 mg/kg BW, 400 mg/kg BW, and injected with CFA into the sub plantar. Bay leaves extract was given one hour per oral before injected with CFA. The measurement of paw edema was done at 24 hours after CFA injection. The result of this study showed that bay leaves extract gave the anti-inflammation effect to the rats which were injected with CFA. It is concluded that bay leaves extract containing flavonoids plays a role in inhibit cytokines proinflammatory synthesis.