bluuebunny/crossref_metadata_2025 huggingface dataset:
JUSTIFICATION OF THE CHOICE OF THE MODEL OF THE BUILDING'S BASE AND FOUNDATION DURING ITS REINFORCEMENT WITH MICROPILES
Authors: KHARCHENKO V. V. , PETRENKO V. D.
Published: June 2023

Purpose. Based on the analysis of the existing experience, to justify the choice of the model of the base and foundation of the building during its reinforcement with micropiles. Such a methodological step will make it possible to adopt a base model, which more fully corresponds to the interaction of micropiles, the foundation of a certain stiffness and the variation of their parameters for further research. Methodology. Foundations, including those reinforced with micropiles, are designed in such a way that the load on the foundation does not exceed a certain limit, which allows calculations for deformations in the compaction phase. To solve the problem, the analysis of the method of general elastic deformations of the base, developed using the hypothesis of an elastic half-space, was carried out. The inclusion of an elastic half-space in theoretical constructs is based on clear and well-established solutions of the theory of elasticity and, more broadly, the mechanics of a solid medium. Also, the considered method is based on limiting the zone of the deformable base (hypothesis of a layer of finite thickness). The cases of application of these hypotheses for the design and calculation of foundations, taking into account their interaction with the foundation were generalized. Findings. It was determined that the elastic layer hypothesis is a more fruitful hypothesis both for foundations in general and for the case of their reinforcement with micropiles. On its basis, it is justified that the finite-element models of the foundation with micropiles and the soil base should have defined limits, which, first of all, allow free deformation of the «foundation – base» system, and, secondly, have dimensions that can be subjected to calculation on a personal computer. Originality. It consists in substantiating the foundation model based on the hypothesis of a layer of finite thickness as the most suitable for numerical experiments using the finite element method. Practical value. It consists in obtaining a justified thickness of the final layer, which is equal to 5 … 6 values of the length of the micropile. It is this thickness, on the basis of which the dimensions of the finite-element model are chosen, that allows the free formation of the stress-strain state of the model and does not contradict the existing requirements for determining this parameter.
BIBLIOGRAPHIC ESSAY ABOUT THE MOSES ABRAMOVICH FRISMANE
Authors: Rybkin V. V. , Kutnyi Ye. O.
Published: June 2023

Биографический очерк о Моисее Абрамовиче Фришмане
MEMORIES OF PROFESSOR T. G. YAKOVLEVA
Authors: Yakovleva T. G.
Published: June 2023

Воспоминания профессора Т. Г. Яковлевой
SIMULATION OF RAILS LIFECYCLE ON THE TRACK
Authors: Rybkin V. V. , Bal O. M.
Published: June 2023

The life cycle modelling of rails in a track is carried out in the paper with the purpose of definition and forecasting of their condition at any moment.
LENGTHENING OR RESTORE WITH WELDED THE RAIL LASHES WITH THE INTRODUCTION OF THE DESIRED FUSING TEMPERATURE USING TENSIONERS
Authors: Novakovych M. V. , Karpachevskyi H. V. , Kurylina I. O. , Potlov O. V.
Published: June 2023

The technology of restoration or lengthening welded rail without joints is described in the article at low temperatures with input in optimum temperature of fastening with application of hydraulic tension devices.
TO ENSURE THE STABLE OPERATION OF CONTINUOUS WELDED RAIL
Authors: Zhadan H. H.
Published: June 2023

The information from history of jointless way onDonetskrailway is shown in the paper. It is considered modern condition and particularities is haved a temperature-strenuous work egalitarian stairwell of jointless way with provision for seasonal change the temperature of rails and installed periodicity of the reconstruction normative delaytion of plugging and mortage bolts.
PERFECTION OF METHODICAL MAINTENANCE OF DISCIPLINES STUDYING THE INTERACTION OF TRACK AND ROLLING STOCK
Authors: Svistunov V. M.
Published: June 2023

The questions of the deepenning the student’s knowledge about interaction of the track and the rolling stock are considered in the article. The attention is paid to widening the themes of investigated questions, the development more perfect methods textbooks on the specified subject, the special collection of the problems on the track and the rolling stock interaction, both for student and for degree designing. This will allow to approach near the theory of the questions to their practical decision.The article is intended for scientists, teachers and student of senior course of railway institutes.
THE USE OF SATELLITE TECHNOLOGY IN PROSPECTING RAILWAYS
Authors: Borisov E. O.
Published: June 2023

The usage of geodesic satellite apparatus of finding the position for research of railroad is considered in the article. The calculations confirm the accordance to accuracy discrete satellite research to the normative demands. The article has the reviewing character.
HIGH TECH APPROACHES TO FORECASTING THE LINEARLY EXTENDED OBJECTS
Authors: Spiridonov E. S. , Yemielianov R. Ye. , Kulikova I. V. , Dienisov O. O. , Zheriebtsova V.
Published: June 2023

The high technology approaches to forecasting development of uniform transport system are considered in the article.
DETERMINATION OF PERMISSIBLE SPEEDS OF FREIGHT CARS ON RAILROAD TRACKS 1520 MM
Authors: Danovych V. D. , Rybkin V. V. , Myamlin S. V. , Reidemeister O. H. , Triakin A. P. , Khalipova N. V.
Published: June 2023

The article is devoted to questions of the admitted speeds establishment of various tipes of freight 4 axis cars movement with carriages 18-100 (ЦНИИ-Х3), in empty and full a condition. The results of the complex researches of dynamic qualities of the cars are given and their influence on a track is appreciated. As a result of researches it is offered to establish different the approach to an establishment of admitted speeds of movement for empty and full cars.
THE LONGITUDINAL FORCES ARISING IN A WAY BEFORE THE BRAKING TRAIN
Authors: Matvietsov V. I. , Kovtun P. V. , Kiebikov O. O.
Published: June 2023

The results of experiment on definition of the additional longitudinal forces arising in a railway ahead of a braking train are considered in the article.
THE RESULTS OF DETERMINING THE ACTUAL VALUES OF TRACK STIFFNESS TO STUDY THE INTERACTION OF TRACK AND ROLLING STOCK
Authors: Taturevych A. P.
Published: June 2023

The results of determining the rigidity and the modulus of elasticity of the track are shown in the paper. They are used for research of track and a rolling stock interaction and they are faking info account the constructions of the permanent way which has been changed for last years especially on concrete crossties. The values of the elasticity modules under the rail are specified under the horizontal bend and rail twist.
RATIONALIZATION OF CURVES RESTRUCTURING PLAN AT HIGHER SPEED MOTION OF TRAINS
Authors: Rybkin V. V. , Kurhan M. B. , Kurhan D. M. , Kharlan V. I.
Published: June 2023

The approach of a reorganization of curves in the plan which is based on minimization of action of a cargo rolling stock for a way and comfortableness of passengers driving at introduction of hight–speed movements is offered.
DETERMINATION OF THE SWITCHES TIME SERVICE
Authors: Danilenko E. I. , Karpov M. I. , Boiko V. D.
Published: June 2023

The technique of definition of normative service life is shown for various parameters of operational conditions depending on characteristics of force loading of a way.
MODERN APPROACH TO DETERMINING THE STRENGTH OF INTERACTION TRACK AND ROLLING STOCK IN THE ZONE OF SWITCHES
Authors: Danilenko E. I. , Molchanov V. M.
Published: June 2023

The calculation technique of definition of forces of a track and rolling stock interaction is shown, the features of its use, calculation schemes are described. The problems arising at calculations of forces of a way and a rolling stock interaction in a tarnout zone and a ways of their resolving are considered.
COMPARATIVE ANALYSIS AND PRACTICAL IMPLEMENTATION OF THE RESULTS OF SUBGRADE CALCULATIONS WITH VARIATION OF DYNAMIC EFFECT
Authors: Buhaiov A. K. , Petrenko V. D. , Tiutkin O. L. , Tsepak S. V.
Published: June 2023

The results of dynamic influence on the subgrade work are shown in the article at the transition to high speed motion. The intrusion of a finite element method in calculations during the innovation of real facilities is done.
THE CONCEPT OF IMPROVING THE DESIGN OF THE TRACK
Authors: Zhelnin H. H. , Lysiuk V. S. , Kuznietsov V. V.
Published: June 2023

In article the basic directions of perfection of a design of a railway in modern conditions of operation are recommended.
ENSURING THE ACCURACY OF RECORDING THE CURVES WITH INCREASING THE TRAIN SPEEDS
Authors: Korzhenevych I. P. , Renhach M. H.
Published: June 2023

In conditions of increasing train traffic speeds the maintenance requirements for curve track sections must be revised to more strict ones. Familiar techniques of surveying curves are analyzed in the paper from the viewpoint of accuracy of the data obtained. Some recommendations on the survey procedures for improving their accuracy are proposed.
THE MATRIX STRUCTURE OF ASSESSMENT OF ORGANIZATIONAL AND TECHNOLOGICAL CAPABILITIES OF CONSTRUCTION ORGANIZATIONS
Authors: Radkevych A. V. , Yakovlev S. O. , Matusevych O. O.
Published: June 2023

The methods of matrix calculation, organizational and technological opportunities of the building company is stated in the paper.
Dasatinib-Induced Colitis: Risk of misdiagnosis of inflammatory bowel disease. A case report and review of the literature
Authors: Graziana Arborea , Anna Maria Valentini , Stefania Marangi , Nicoletta Labarile LT , Maria Teresa Savino
Published: June 2023

Dasatinib is a potent tyrosine kinase inhibitor, in disease states associated with BCR/ABL 1, approved in 2006 for chronic myeloid leukemia treatment. This agent has been shown to exhibit broad off-target kinase inhibition and immunomodulating properties. These effects may be responsible for common adverse reactions (> 15%) which include immunosuppression, cytopenias, pleural effusion and other fluid retention, diarrhea, and other gastrointestinal side effects. Although gastrointestinal bleeding is a well-documented side effect, the presentation of colitis is an uncommon occurrence. In most cases, it is hemorrhagic colitis, nonspecific colitis, or CMV-related colitis. We report a 34-year-old male patient affected by CML in treatment with Dasatinib for approximately 1 year, who reported chronic diarrhea which progressed to suspected Dasatinib-induced colitis whose clinical, endoscopic, and histological findings overlapped those of Inflammatory Bowel Disease.
Isolation and storage of PBMCs from human peripheral blood samples v1
Authors: Zhao Yunge
Published: June 2023

This protocol descried detailed steps on how to isolate and store PBMCs from human peripheral blood samples. By following this protocol, you can isolate and store PBMCs for up to 1 year. Then you can perform antibody staining on samples of different timepoints/batches for flow cytometry analysis once.
Preparation of mollusc larval shells for individual geochemical analysis v2
Authors: Mouchi Vincent
Published: June 2023

This protocol describes the digestion process of mollusc larvae and is modified from the procedure found in Becker et al. (2005). Here, we indicate the entire process to obtain the digestion solution, as well as cleaning glassware, actual larval digestion and extraction of shells until storage for subsequent geochemical analysis or observation. This protocol is applicable to shelly larvae of any species, once they are collected and brought to the laboratory. The goal of this preparation is to isolate each larval shell to perform individual geochemical analyses, instead of dissolving several specimens for bulk analysis. To do this, great care needs to be taken to the handling of the shells using ultra-pure solutions and acid-washed glassware to avoid chemical contamination of all kind. Reference: Becker, B.J., Fodrie, F.J., McMillan, P.A., Levin, L.A., 2005. Spatial and temporal variation in trace elemental fingerprints of mytilid mussel shells: a precursor to invertebrate larval tracking. Limnology and Oceanography, 50, 48-61. doi: 10.4319/lo.2005.50.1.0048.
Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect v2
Authors: L Blanz Stephan
Published: June 2023

This protocol was used to collect data now published in the Journal of Neural Engineering, Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect using the multi-contact ImThera stimulating device. https://doi.org/10.1088/1741-2552/acb3fd Dataset has been published to pennsieve.io and can be found at: https://doi.org/10.26275/efbj-8evl
Declinaciones de la(s) violencia(s) en la miniserie Maid
Authors: Moreira Marcos Cristina , Costa de Souza Pena Dayane , Monteiro Hallak Bruna
Published: June 2023

Desde la perspectiva del psicoanálisis, la violencia contra la mujer debe ser abordada como una violencia dirigida a lo femenino, concepto lacaniano que no se agota en la anatomía ni en la dicotomía de hombre/mujer, sino que concierne a diferentes modos de goce. Aunque se hayan alcanzado muchos avances en el campo social y jurídico, el enfrentamiento de la violencia sigue siendo un tema que demuestra la fragilidad y la necesidad de políticas y derechos para las mujeres. A partir de la miniserie Maid, nos apoyamos en la articulación entre los recursos de la imagen y del discurso que allí se realizan, para abordar puntos específicos coherentes con el problema, y extraemos consecuencias para la teoría y la clínica. Así, buscamos interrogarnos sobre posibles estrategias subjetivas para enfrentar la violencia doméstica.
Penélope de Joyce: la astucia, un destino de lo femenino
Authors: Rocha de Oliveira José Augusto , Valle Dupim da Silva Gabriella
Published: June 2023

El propósito de este artículo es discutir un destino de lo femenino que no implica las soluciones falocéntricas freudianas. Para ello, revisa los cursos de Freud y de Lacan sobre la feminidad y lo femenino, respectivamente. Sin embargo, recurre a un episodio del Ulises de James Joyce, en específico el monólogo de Molly Bloom, para ilustrar lo que una mujer puede hacer astutamente con el saber hacer del goce femenino.
Multi-criteria Assessment Using AHP Techniques for Agricultural Land Suitability Sharazoor and Sharbazher, Sulaimani as a Case study
Authors: Ahmed Sivan , Hama Ako , Ziboon Abdul
Published: June 2023

Land suitableness evaluation should be essential before implementing any specific land use, particularly within the agricultural sector. The aim of this study was to determine suitable lands for agricultural use in the Sharazoor and Sharbazher districts. The Analytical Hierarchy Process method, commonly used in land-use suitability analysis, was used in this study. According to Analytical hierarchy process (AHP) techniques, to generate a land suitability graph various main criteria such as climate (rain, temperature, humidity), soil (texture, colour, PH ), land (elevation, slope, area, distance), and Agriculture services (Crop rotation, pesticide type, planting scheduling date, Seed variety, farm management, education level, number of personal work in the farm, equipment, production rate, planting rate, planting days, harvesting) factors were used. The questionary form is created. The form was distributed to academic people and ideal farmer for determine the importance of each criterion. In the result, the weight value is 0.465, 0.242, 0.209, and 0.084 for the Climate, Soil, Land, and Agriculture service respectively. Climate criteria are most important, and Agriculture has the least influence over decision-making procedures. According to AHP techniques, the ranking value ranges between 6.48-5.06 for producing wheat in the study area. The suitable land for producing wheat is in Kanispika village. Kelakawa Village's land is best suited for producing barely, when ranking values ranging from 6.08 to 5.15.
Flexural Strength and Behavior of Flat Steel Plate-Concrete Composite Beams
Authors: Hassan Kawan , Saeed Jalal
Published: June 2023

Steel rebar’s are widely used as main flexural reinforcement in reinforced concrete beams. It’s quite attractive to explore the use of another type of material for this purpose. This study aims to investigate the flexural behavior of reinforced concrete beams using steel checker plates instead of traditional steel rebar’s.

In this study fourteen simply supported beams where cast and tested under two-point loads. All the beams had the same steel reinforcement and the dimensions of 2000 mm in length, 250 mm in height and 200mm in width, twelve specimens of these beams were reinforced by horizontal and vertical checker steel plates having total thickness (12mm) with different arrangements and end anchorages. Two of these specimen beams were control beams reinforced with rebar’s. The main variables of the research arrangement, number and anchorage of steel checker plates. Based on the experimental results it found that there is a reduction in crack load and ultimate load of composite steel checker plate beams as compared to reinforced beams. In contrast there was observed increment in ductility of checker steel plate beams compared with beam reinforced with normal rebar’s, while in different arrangements (vertical and horizontal) of steel plates, with same cross sectional area when the number of checker plates increased the load also increased by 14% 12% and 8% also 11%, 23% and 27% for both cracking and ultimate loads respectively. Also the deflection of steel checker plate beams after failure was more than steel bars
PERSONEL GÜÇLENDİRMENİN İŞ TATMİNİ ÜZERİNE ETKİSİ: BANKACILIK SEKTÖRÜ ÇALIŞANLARI ÖRNEĞİ
Authors: GÜREL Pınar Altınok
Published: June 2023

Günümüzde örgütler pazar yapısının, teknolojinin ve müşteri isteklerinin hızla değiştiği bir ortamda faaliyette bulunmaktadırlar. Bu yoğun rekabet ortamında, geleneksel örgüt yapısının yerine, çalışanların daha fazla sorumluluk aldığı ve yaptıkları işi sahiplendikleri bir örgüt yapısı anlayışına ihtiyaç vardır. Bir yönetim kavramı olarak personel güçlendirme, yardımlaşma, paylaşma, yetiştirme ve ekip çalışması yolu ile kişilerin karar verme haklarını (yetkilerini) arttırma ve kişileri geli ştirme sürecini kapsamaktadır. Personel güçlendirme faaliyetleri sonucunda, çalışan işini sahiplenecek ve işindeki sorumluluğunun bilinciyle daha fazla çaba sarf ederek, motivasyon, iş memnuniyeti ve örgütsel bağlılık üzerinde olumlu etkiler yaratarak ver imliliği arttıracaktır. Bu çalışmanın amacı, bankacılık sektöründe 625 çalışan için personel güçlendirmenin iş tatmini üzerindeki etkisinin regresyon analizi yardımıyla belirlenmesidir. Analiz sonucunda personel güçlendirmenin iş tatminini pozitif yönde %3 9.8 arttıracağı belirlenmiştir.
Extracción y purificación de papaína obtenida a partir de tres especies nativas del género Vasconcellea
Authors: Rivera-Botonares Ralph Stein , Oliva-Cruz Segundo Manuel , Tineo Flores Daniel
Published: June 2023

En esta investigación se obtuvo la enzima papaína a partir de látex de tres especies del género Vasconcellea, V. chachapoyensis, V. heilbornii y V. pubescens, especies nativas de la región Amazonas en Perú. El látex extraído se acondiciono con buffer acetato de sodio, EDTA y solución de bisulfito de sodio. La purificación se realizó adaptando el método de Andrade (2011), se utilizó sulfato de amonio para la precipitación; etanol de 96° en dos etapas para la dilución; se regulo el pH a 6.0 y 8.0 con NaOH 0.1 N, se centrifugo en tres etapas; se congelo a -65 °C por 12 horas; y liofilizo de 24 a 36 horas con vacío de 0.1 a 0.6 mbar y temperatura de colector de -84 a -85 ° C, finalmente se envaso en frascos oscuros. Utilizando el método de coagulación de leche (Balls and Hoover) se determinó la actividad enzimática (AE), las tres especies obtuvieron mayores valores de AE a pH 6.0 que a pH 8.0; la V. chachapoyensis presento mayor promedio significativo de AE (240.97 Upe), seguido de V. pubescens (195.80 Upe) y V. heilbornii (112.45 Upe), también fue significativamente superior a la papaína comercial (208.14 Upe). La V. pubescens tuvo mayor actividad proteolítica que las otras especies.
Dibujos animados: el arte del movimiento: Jeisson: la historia de un cortometraje de animación
Authors: Gama Castro María Martha
Published: June 2023

Jeisson surgió como historia a través de conversaciones con diferentes personas en uno de esos viajes que llevó a mi familia a recorrer una región llena de magia y belleza natural, Buenaventura. Desde entonces, entendí que tenía que narrar esta historia y que además debía hacerlo en un corto animado. La historia es emocional, aspecto que es importante considerar en una narración audiovisual para el resultado final. El libro es el resultado del desarrollo de un proyecto de animación que se fundamenta en la descripción, las salidas de campo y las historias de cada uno de los personajes que la conforman, sin olvidar la importancia del lenguaje estético y visual. El aporte artístico y experimental de este corto fue, desde sus inicios, el verdadero fundamento de este proyecto. La forma como se construye el libro, integrando la historia desde su proceso de preproducción, producción y posproducción, además de su posible expansión al lenguaje transmedia, logra reunir, académica y descriptivamente, las etapas del proceso que se llevan a cabo en un corto animado, buscando siempre reunir a los estudiantes que consideren este texto como referencia para el desarrollo de sus propios proyectos.
В статье рассматривается практика йоги. Изучается вопрос популярности среди студентов СГЭУ занятий йогой. Приводятся данные опроса студентов относительно востребованности занятий йогой в качестве разновидности занятий по физическому воспитанию
Authors: Шалимова О.Н.
Published: June 2023

В статье на основании научно педагогической литературы рассматривается процесс языковой подготовки будущих юристов на занятиях по иностранному языку.
Возможность изучения фразовых глаголов путем прослушивания любимых песен
Authors: Гришин Р.С. , Андреева Е.А.
Published: June 2023

В работе проведен анализ работы над фразовыми глаголами. То есть рассмотрены сами фразовые глаголы, что они из себя представляют и какие разновидности бывают. Показана актуальность изучения данных глаголов и языка в целом, приведены некоторые примеры словосочетаний и песен, а также проведен опрос и поставлен эксперимент обучающимися, которые не знают язык в совершенстве.
Формирование межкультурной толерантности у студентов колледжа на уроках английского языка
Authors: Исакжанова И.П.
Published: June 2023

В статье рассматривается различие трактовки терминов толерантность и терпимость, ссылаясь на определения терминов данные в различных словарях. Раскрыто определение межкультурной толерантности. Приведены доказательства влияния изучения иностранного языка на формирование толерантной личности в условиях среднего профессионального образования.
Занятие по химии с лабораторными экспериментами наночастиц
Authors: Кондрашкина А.Э.
Published: June 2023

В статье предлагается ввести нанотехнологии и наночастицы во внеклассные уроки, поскольку они не включены в действующую учебную программу по химии. В статье подчеркивается важность практико-ориентированного образования и предоставления студентам знаний о научно-технических достижениях. Наночастицы и нанотехнологии становятся все более важными в современном мире, и учащиеся должны быть осведомлены о последних открытиях в этой области. Школьная программа по химии в настоящее время не включает раздел о нанотехнологиях, поэтому авторы статьи предлагают серию внеклассных курсов и лабораторных экспериментов для познакомления учащихся с коллоидной химией наночастиц.
Особенности разработки модульных программ в системе дополнительного образования
Authors: Ликсина Е.В. , Сафронов Н.В.
Published: June 2023

В статье рассматриваются вопросы проектирования модульных программ, особое внимание уделено использованию модульной технологии в системе дополнительного образования. Описываются основные уровни образовательных программ, а также основные типы модулей.
Влияние спортивного плавания на физическую подготовку и здоровье студента
Authors: Низамов Д.И. , Илюшин О.В.
Published: June 2023

Данная статья описывает основные преимущества спортивного плавания для физической формы, а затем его влияние на здоровье. Затем будут рассмотрены факторы, влияющие на воздействие спортивного плавания на физическую форму и здоровье, а также потенциальные риски и меры предосторожности. В конце статьи подводятся основные итоги и подчеркивается важность спортивного плавания для физической подготовки и здоровья студентов.
Computer Network: An Implementation of MAC Spoofing
Authors: Jain Lalit
Published: June 2023

An exponential growth has observed of network or internet users due to diverse resource and information sharing services. Contrary, network uses also increased in different kinds of attacks. Means network is vulnerable for many types of attacks. Computer network may exploit in different contexts such as denial of service, ping death, malfunction routing, flooding, man in the middle and spoofing attack. Among of these MAC spoofing is kind of attack spoofing attack that target to MAC or physical address of the network host or router. It tampers original address to any other random or user defined address. The aim of the study is to present MAC address and its types. With this, MAC spoofing attack also presented. Implementation environment and method for the MAC spoofing also presented. MAC spoofing is implemented in the KALI Linux operating system with the help of MACCHANGER tool.
Implementation of Blockchain technology
Authors: Sharma Manju
Published: June 2023

Transaction volumes throughout the world are growing very fastly and that result in the complexities, vulnerabilities, inefficiencies, and higher costs of current transaction systems. The growth of ecommerce, online banking, and in-app purchases, is increasing and is more popular among the people around the world. And transaction volumes are increasing with the advent of the Internet of Things (IoT). Objects, such as laptop, washing machines and groceries are running low and cars that deliver themselves to your door. To meet these challenges and others we need faster payment methods that are trustworthy and require no specialized equipment with no chargebacks or monthly fees and offer a good bookkeeping solution for ensuring transparency.
Postdigital Intimacies for Online Safety
Authors:   Coventry University, UK, Balfour Lindsay , Evans Adrienne ,   Coventry University, UK, Maloney Marcus ,   Coventry University, UK, Merry Sarah ,   Coventry University, UK
Published: June 2023

This report offers a multi-sector response to the Online Safety Bill (OSB). The shape and content of the OSB has generated discussion amongst policy specialists, stakeholders and lobbyists in key services and sectors, political advisors and appointed representatives, and academics and researchers – as well as a general public interested in what the OSB will mean for people made vulnerable or at risk of harms online. We report on the discussions that took place in four co-production workshops with representatives from the areas of: intimate digital health tools and services marketed to those who identify as women; image-based and technologically-enabled abuse; “toxic” internet communities; and protections for people with mental health conditions and neurodiversity. As the OSB reaches the final stages of approval through the UK government, this report provides a response from people working in these areas, highlighting the voices and perspectives of those invested in ensuring a vibrant, equal, inclusive, and safe digital society can flourish. Our recommendations include the need for: robust, transparent risk assessment and frameworks for preventing harm that work across life-stages; going above and beyond the current OSB legislation to raise awareness and educate to reduce harms; recognition in the OSB and elsewhere of the national threat of Violence Against Women and Girls (VAWG); and, an increase in information sharing and working across sectors of the technology industry, service providers, and charity, law, and government to generate new approaches for a better future.
РОЗРОБКА ІНВЕСТИЦІЙНОЇ СТРАТЕГІЇ РОЗВИТКУ НАЦІОНАЛЬНОЇ МЕРЕЖІ МІЖНАРОДНИХ ТРАНСПОРТНИХ КОРИДОРІВ
Authors: Зайцева І. Ю. , Бондарчук О. А.
Published: June 2023

У статті визначено, що одним із найважливіших інструментів розробки та реалізації управлінських рішень щодо інвестиційної діяльності є інвестиційна стратегія. Доведено, що ефективним інструментом перспективного керування інвестиційною діяльністю направленої на розвиток об’єктів МТК та реалізації цілей для загального розвитку в умовах істотних змін макроекономічних показників, системи державного регулювання ринкових процесів, кон'юнктури інвестиційного ринку що зв'язаної з невизначеністю, виступає інвестиційна стратегія. Доведено, що інвестиційну стратегію можна представити як генеральний план по функціонуванню та розвитку інвестиційної діяльності в межах національної мережі міжнародних транспортних коридорів, що визначає пріоритети і напрямки, форми, характер формування інвестиційних ресурсів і послідовність етапів реалізацій довгострокових інвестиційних цілей, що забезпечують передбачений загальний розвиток МТК на території України.
ПОСИЛЕННЯ РОЛІ ДЕРЖАВИ НА РИНКУ ПОЗИЧКОВИХ КАПІТАЛІВ: НАПРЯМКИ ТА РЕЗУЛЬТАТИ
Authors: Непран А. В. , Тимченко І. Є. , Каменева Н. М.
Published: June 2023

Стаття присвячена аналізу ролі держави на внутрішньому ринку позичкових капіталів України. Зроблено висновок, що зростання державних запозичень протидіялоактивній кредитній політиці, не змогло перешкодити виникненню в 2015–2018 рр. серйозної  напруженості на ринку позичкового капіталу. Ринок позичкових капіталівстав виконувати не властиву йому функцію — завдяки позикам держава здійснює монетизацію статутного капіталу державних банків,  відшкодовує суми податку на додану вартість та ін. Встановлено, що внаслідок різкого збільшення державних запозичень баланс взаємовідносин держави та ринку позичкових капіталів став  негативним. Акумуляція державою значних грошових коштів на внутрішньому ринку позикових капіталів «підштовхувала» зростання процентних ставок. Характерноюособливістю розвитку ринку позичкових капіталів в Україні за останнє десятиріччя є посилення процесів централізації і  перерозподілу вільних коштів з боку держави.
SMALL AND MEDIUM-SIZED BUSINESSES: TACKLING COVID-19 CHALLENGES BY CHANGING BUSINESS-MODELS
Authors: Poliarus O. V. , Nazarenko I. L.
Published: June 2023

In this paper the surveys conducted on small- and medium-sized enterprises around the world (including Ukraine) have been analyzed. SMEs face a  bigger risk than larger firms affected by COVID-19 pandemic. Although governments support them to a certain extent, SMEs are trying to survive the pandemic by themselves. It is true especially for Ukraine, where SMEs are an important element of economy (as they account for 77,9 percent of employment, generate 64,4% of share value added and 20 percent of GDP), but they do not have much hope for government help and do almost without it. Therefore they cut their costs, make employees  redundant, seek other ways to approach their customers despite severe COVID restrictions, and so on. They also adjust their business models to the new harsh environment, but they need guidance in this realm, how to make it correctly and efficiently.Having analyzed 4 types of solutions offered by R. Ackoff, we arrived at the conclusion of using one of them for SMEs - Solution, to comply with the principles of applied systems analysis. Absolution appeared ineffective, Resolution – not effective enough, and Dissolution – inapplicable for dissolving problems caused by COVID-19.For adjusting business-models we suggest owners of SMEs use Business Model Canvas by A. Osterwalder as a simple and comprehensive one. To the Canvas we added influence linesto show that some blocks influence mainly Cost structure, some others – mainly Revenue streams, and Value proposition, both of them. It could be said that Cost Structure is mainlyaffected from the supply side, and Revenue streams – from the demand side.The Template of Business Model Change for SMEs has bees worked in this study. It encompasses 2 levels: the first level – Analysis (the main points which SMEs owners should analyse first) and the second level – some main solutions which could be developed according to the analysis carried out. We have united 2 blocks devoted to customers into the one  (Customers&Relationships) so that prospective users could better understand these interconnected blocks and making decisions within them. The Template is practically applicable for changing the business models of small and medium-sized enterprises in Ukraine and any other country as well.The results obtained in the study can be used in further research in this realm.
THE COMPETITIVE ADVANTAGE OF SIDO MUNCUL: USING PESTLE, PORTER’S FIVE FORCES, AND SWOT MATRIX ANALYSIS
Authors: Kho Ardi , Tan Jacob Donald , Nugroho Michael Prayogo , Kornelius Stefani Mutiara , Prayoga Sonnia , Adi Stephen
Published: June 2023

Sido Muncul is a company engaged in herbal medicine, pharmaceutical, traditional medicine, health food and beverage, cosmetics, and herbal processing. It is continuously innovating its products and keeping an eye on market needs. Sido Muncul gains a place in the hearts of consumers and is one of its business strategies. In addition, Sido Muncul is also expanding into foreign markets to market and sell its products. This study uses the description of PESTLE analysis, Porter 5 Forces, and SWOT Matrix because it experiences significant challenges from competitors, regulations, the economy, internal companies, and changes in consumer behavior. Based on the PESTLE, Porter 5 Forces, and SWOT Matrix analysis, Sido appears to have strength in market growth and has unique products and competencies to survive in competition, gain profits and continue improving efficiency and product innovation. The company needs to improve: the younger generation does not use herbal products for health.
Opportunities for engineering outer membrane vesicles using synthetic biology approaches
Authors: Kelwick Richard J. R. , Webb Alexander J. , Freemont Paul S.
Published: June 2023

Gram-negative bacteria naturally shed lipid vesicles, which contain complex molecular cargoes, from their outer membrane. These outer membrane vesicles (OMVs) have important biological functions relating to microbial stress responses, microbiome regulation, and host-pathogen interactions. OMVs are also attractive vehicles for delivering drugs, vaccines, and other therapeutic agents because of their ability to interact with host cells and their natural immunogenic properties. OMVs are also set to have a positive impact on other biotechnological and medical applications including diagnostics, bioremediation, and metabolic engineering. We envision that the field of synthetic biology offers a compelling opportunity to further expand and accelerate the foundational research and downstream applications of OMVs in a range of applications including the provision of OMV-based healthcare technologies. In our opinion, we discuss how current and potential future synergies between OMV research and synthetic biology approaches might help to further accelerate OMV research and real-world applications for the benefit of animal and human health.
The secretome as a biomarker and functional agent in heart failure
Authors: Nyarko Obed O. , Sucharov Carmen C.
Published: June 2023

Heart failure (HF) is a complex and multifactorial disease. Recent advances have been made in understanding the underlying molecular processes involved in HF pathogenesis. These scientific advancements have brought to light the importance of the secretome. This paper presents a thorough overview of the state of science regarding the secretome's involvement in the onset, progression, and possibility of improved diagnosis and therapeutic interventions in HF. We explore the various types of secreted factors, including novel proteins, growth factors, cytokines, and microRNAs. We also discuss how they affect cellular signaling, angiogenesis, fibrosis, pathological cardiac remodeling, and inflammation in HF. Furthermore, we examine the role of the secretome in cardioprotection and cardiotoxicity. This review emphasizes the potential of the secretome for biomarker discovery. This might enable better HF diagnosis, risk stratification, monitoring and treatment. The review also discusses the difficulties on investigating the role of secreted factors and novel directions on secretome research. It highlights its potential as a target for novel therapeutic approaches and biomarker development.
Cultural and Morphological Features of Trametes versicolor (Polyporaceae) Growth on Wood Hydrolyzes Containing Media
Authors: Zubyk Pavlo , Klechak Inna
Published: June 2023

Background. Trametes versicolor is a representative of basidiomycota, whose biologically active compounds are used in medicine and industry, so the search for active producers capable of growing on industrial waste and the study of new ways of intensification of growth and synthesis of metabolites are relevant task.
Objective. Investigation of the effect of Fagales sawdust extracts on growth, morphological characteristics, and induction of synthesis of oxidizing enzymes by macromycetes of the species T. versicolor in surface culture.
Methods. The objects of research were 5 strains of T. versicolor, which were cultivated on the synthetic agarized Norcrans media on Petri dishes. The influence of the sawdust extracts of 3 tree species, which acted as a basis for research media, was studied. The following cultural indicators were investigated: colony size, radial growth rate, and growth rate. The research also covered the study of macromycetes' morphological characteristics and the ability of Fagales sawdust extracts to induce the synthesis of oxidative enzymes.
Results. It is established that growth on media with the addition of birch extract is more intense: the radial growth rate is 11.2–13.6 mm/day, while for beech and oak, the growth rate ranges from 11.6–13.1 and 11.5–12.6 mm/day respectively. The highest growth value on all media is recorded for T. versicolor 353. The value of the growth rate on the medium with birch sawdust extracts varied in the range 15.8–92.1, for medium with beech extracts – 19.4–46.1, with oak extracts – 15.5–46,7, and the highest growth value was recorded during the cultivation of T. versicolor 5299. The beech and oak sawdust extracts intensified the synthesis of laccase, peroxidase, and tyrosinase, which was strongly expressed in T. versicolor 353, so it was chosen for further experiments with submerged cultivation.
Conclusions. Birch, beech, and oak sawdust extracts can be used to increase the accumulation of T. versicolor biomass while beech and oak sawdust extracts are preferable for the intensification of the synthesis of oxidase-type enzymes.
Geographical Factors Determining the Transmission of COVID-19: Lessons Learned from Turkish Black Sea Region to Face Next Pandemic Crisis
Authors: Akan Aytac Perihan , Coccia Mario
Published: June 2023

The objective of the present study is to analyze COVID-19 transmission in specific dampest regions with excess rainfall and recurring fogs. The working hypothesis is that widespread transmission of SARS CoV 2 (leading to COVID-19) and similar viral agents can be explained by specific climate factors having high air humidity. The main case study of the Turkish Black Sea region is investigated. Results reveal that the provinces in region under study have some climate factors and geographical features that foster the accelerated transmission of viral agents, such as SARS-CoV-2, and consequential negative impact on society. In particular, Spearman's Correlation Coefficient shows a statistically significant positive association between the average atmospheric pressure and the spread of the COVID-19 confirmed cases in Samsun province (Spearman’s correlation coefficient rs =0.86, p-value 0.05). A statistically significant positive association between the average precipitation and the spread of COVID-19 confirmed cases in Sinop province (Spearman’s correlation coefficient rs =0.79, p-value 0.05), and finally, a statistically significant negative association between the average sun hour and the spread of the COVID-19 confirmed cases in Samsun province (Spearman’s correlation coefficient rs = 0.89, p-value 0.01). These findings suggest that regions' geographical characteristics, demographic structure, climate and environmental parameters must be considered in the national scale epidemic management plans to design effective anti-pandemic health policies to cope with future waves of the COVID-19 and new airborne diseases and to reduce negative effects on health, social and economic systems.
Suppression of NASH-Related HCC by Farnesyltransferase Inhibitor Through Inhibition of Inflammation and Hypoxia-Inducible Factor-1α Expression
Authors: Yamada Kohei , Tanaka Tomokazu , Kai Keita , Matsufuji Shohei , Ito Kotaro , Kitajima Yoshihiko , Manabe Tatsuya , Noshiro Hirokazu
Published: June 2023

Inflammatory processes play major roles in carcinogenesis and progression of hepatocellular carcinoma (HCC) derived from non-alcoholic steatohepatitis (NASH). But there are no therapies for NASH related HCC, especially focusing on these critical steps. Previous studies reported that farnesyltransferase inhibitors (FTIs) have anti-inflammatory and anti-tumor effects. However, the influence of FTIs on NASH-related HCC has not been elucidated. In HCC cell lines, HepG2, Hep3B, and Huh-7, we confirmed expression of hypoxia-inducible factor (HIF)-1α, an accelerator of tumor aggressiveness and the inflammatory response. We established NASH-related HCC models under inflammation and free fatty acid burden and confirmed that HIF-1α expression was increased under both conditions. Tipifarnib, which is an FTI, strongly suppressed increased HIF-1α, inhibited cell proliferation, and induced apoptosis. Simultaneously, intracellular interleukin-6 as an inflammation marker was increased under both conditions and significantly suppressed by tipifarnib. Additionally, tipifarnib suppressed expression of phosphorylated nuclear factor-κB and transforming growth factor-β. Finally, in a NASH-related HCC mouse model burdened with diethylnitrosamine and a high fat diet, tipifarnib significantly reduced tumor nodule formation in association with decreased serum interleukin-6. In conclusion, tipifarnib has anti-tumor and anti-inflammatory effects in a NASH-related HCC model and may be a promising new agent to treat this disease.
Building Ensemble of Resnet for Dolphin Whistle Detection
Authors: Nanni Loris , Cuza Daniela , Brahnam Sheryl
Published: June 2023

To effectively preserve marine environments and manage endangered species, it is necessary to employ efficient, precise, and scalable solutions for environmental monitoring. Ecoacoustics provides several benefits as it enables non-intrusive, prolonged sampling of environmental sounds, making it a promising tool for conducting biodiversity surveys. However, analyzing and interpreting acoustic data can be time-consuming and often demands substantial human supervision. This challenge can be addressed by harnessing contemporary methods for automated audio signal analysis, which have exhibited remarkable performance due to advancements in deep learning research. This paper introduces a research investigation into developing an automatic computerized system to detect dolphin whistles. The proposed method utilizes a fusion of various resnet50 networks integrated with data augmentation techniques. Through extensive experiments conducted on a publically available benchmark, our findings demonstrate that our ensemble yields significant performance enhancements across all evaluated metrics.
The MATLAB/PyTorch source code is freely available at: https://github.com/LorisNanni/
Image Data Extraction and Driving Behavior Analysis Based on Geographic Information and Driving Data
Authors: Lin Huei-Yung , Zhang Jun-Zhi , Chang Chin-Chen
Published: June 2023

This paper proposes an approach for image data extraction and driving behavior analysis using geographic information and driving data. Information derived from geographic and global positioning systems was used for image data extraction. In addition, we used an onboard diagnostic II and a controller area network bus logger to record driving data for driving behavior analysis. Driving behavior was analyzed using sparse automatic encoders and data exploration to detect abnormal and aggressive behavior. A regression analysis was used to derive the relationship between aggressive driving behavior and road facilities. Several traffic improvements were proposed for specific intersections and roads. The results indicate that lane ratios without lane markings and with straight lane markings are important features that affect aggressive driving behaviors.
Cartilage Conduction Hearing Aids in Clinical Practice
Authors: Nishimura Tadashi , Hosoi Hiroshi , Shimokura Ryota , Kitahara Tadashi
Published: June 2023

A relatively loud sound is audible when a vibrator is attached to the aural cartilage. This form of conduction is referred to as cartilage conduction (CC). In Japan, a new type of hearing aid has been developed using CC and is available in clinical practice since 2017. A clinical study conducted prior to its launch demonstrated its benefits, particularly in patients with aural atresia who were unable to use air-conduction hearing aids. Several studies have been published on the benefits of CC hearing aids since their introduction in clinical practice. Most of the patients included in these studies had canal stenosis or aural atresia, and the purchase rates of CC hearing aids in these patients were relatively high. However, the number of patients with open ears was small, with overall poor results in the trials, with the exception in patients with continuous otorrhea. CC hearing aids are considered a good option for compensating hearing loss in ears with canal stenosis or atresia in both bilateral and unilateral cases. However, CC hearing aids are not currently considered the first choice for patients with an open ear,.
Stable Coronary Artery Disease: Who Finally Benefits from Coronary Revascularization in the Modern Era? The ISCHEMIA and Interim ISCHEMIA-EXTEND Analysis
Authors: Bershtein Leonid L , Sumin Alexey , Zbyshevskaya Elizaveta , Gumerova Victoria , Tsurtsumia Darejan , Kochanov Igor , Andreeva Alina , Piltakian Vartan , Sayganov Sergey
Published: June 2023

Coronary revascularization is one of the most studied treatment modalities in cardiology, however, there is no consensus among experts about its indications in patients with stable coronary artery disease (SCAD). Contemporary data regarding the role of revascularization in SCAD are in clear conflict with the current European guidelines. This article discusses the main statements of the most significant American and European Guidelines on myocardial revascularization of the last decade, and also analyzes the appropriateness of revascularization to improve the prognosis and symptoms in CCS in the light of new research data, primarily the ISCHEMIA study (NCT01471522) and ACC/AHA 2021 Revascularization Guidelines based on them. Data on the revascularization in CCS obtained after the completion of ISCHEMIA (including the interim analysis of ISCHEMIA-EXTEND) and their potential significance are discussed. The results of ISCHEMIA sub-analyses in the most important ‘controversial’ subgroups (3-vessel disease, proximal left anterior descending artery (LAD) disease, strongly positive stress test, etc.) are reviewed, as well as the results of the ISCHEMIA-CKD substudy in patients with severe chronic kidney disease (CKD).