bluuebunny/crossref_metadata_2025 huggingface dataset:
Meme Culture: A Study of Humor and Satire in Digital Media
Authors: Ayu Lestari Dita , Primagara Megi , Aulia Sari Shinta , Meilina Afifah , Fauziah Silfiah , Irfany Sugesti Ade , Nasywa Aisyah , Diva Salwi Ahmad
Published: July 2024

Meme culture is an interesting phenomenon in digital media that plays an important role in digital communication and culture that has become a popular tool for conveying information and ideas that spread rapidly on the internet and social media platforms. The purpose of this study is to examine more deeply how the satire discourse is contained in pictorial texts and purely texts in memes how the role of memes in digital media, and how their impact in digital media as well as knowing how the role of memes in shaping individual and group identity. This research is interesting because the satirical humor style contained in memes is an effective, practical, absurd response to entertainment, politics, education, culture, and others and can shift, exclude, and reverse discourse, because it can create new discourse. This research study uses critical discourse analysis by Norman Fairclough, which identifies that discourse can be a series of spoken and written words or a series of speech acts. With this analytical knife, it was found that satire in memes on social media is used in the form of satire and criticism of things that are going viral and how these issues affect social media in the real world. Memes are not seen as silent, passive, and ready-made texts when produced. Instead, memes are dynamic and mobile strategies through comedic satire.
AS TRANSFORMAÇÕES NA DISCIPLINA DE SOCIOLOGIA COM A REFORMA DO ENSINO MÉDIO NO INTERIOR DO ESTADO DO MARANHÃO
Authors: Castro Juliana Moraes , Pereira Amanda Gomes
Published: July 2024

Com a implementação da Medida Provisória 746 (MP 746/20162), que, posteriormente, tornou-se a Lei 13.145/20173, mediante sua aprovação no Congresso Nacional vigorou no Brasil uma política de enfraquecimento entorno das políticas públicas educacionais e da produção da Ciência, em contrapartida ao alinhamento e fortalecimento de tendências neoliberais. Com o novo formato, a disciplina de Sociologia sofreu com a redução de sua carga horária, tendo em vista que, com a nova configuração, o currículo se encontra organizado em Itinerários Formativos, a quais estão distribuídos em três componentes, sendo, eles Aprofundamento, Eletivas e Projeto de Vida para com os quais estes componentes devem conversar com os quatro eixos estruturantes (Investigação Cientifica, Mediação e Intervenção Sociocultural, Processos Criativos e Empreendedorismo), voltando-se, portanto, para uma formação técnica e profissional. Ao privilegiar uma educação utilitária e mercadológica, a reforma passa a corroborar com os interesses predominantes de grandes corporações particulares do setor educacional, bem como a preparação de mão de obra para fomentar a economia capitalista, contribuindo desta maneira com a precarização da educação pública brasileira. Nessa perspectiva, o objetivo deste trabalho é fazer uma reflexão sobre as transformações e impactos em torno da disciplina de Sociologia com a reforma do ensino médio, na rede estadual do município de São Bernardo, estado do Maranhão. Metodologicamente, optou-se, pela pesquisa de cunho qualitativa empregando métodos da Antropologia como a escrita do diário de campo. A escrita deu-se também mediante o arcabouço teórico disponível e os dados adquiridos com a entrada dos pesquisadores em campo. Participou da pesquisa um professor da disciplina de Sociologia da respectiva rede de ensino. Como conclusão, apontamos alguns dos problemas atualmente vivenciados por professores da rede de ensino do estado do Maranhão que já vinham antes mesmo da aprovação da reforma, como a falta de infraestrutura adequada das escolas para a real oferta e garantia dos itinerários formativos.
11 Gjenocidi kulturor? Fillon me shkatërrimin e arkitekturës
Authors: Bekim Baliqi
Published: July 2024

Recension 

Bevan, Robert. 2023.  Shkatërrimi i kujtesës: Arkitektura në luftë” Cuneus: Prishtinë, përkthyer në gjuhën shqipe nga Florina Jerliu. [Titulli origjinal: The Destruction of Memory: Architecture at War, 2nd expnaded edition, London: Reaktion Books, 2016]
9 Falje, dëgjim, pritje: Etika e solidaritetit në lëvizjen e Kosovës për rezistencë paqësore në vitet 1990-ta
Authors: Arbër Jashari
Published: July 2024

Në kohën kur shpërbërja e Jugosllavisë në vitet e hershme të dekadës së 1990-ve u kthye në dhunë ndërmjet republikave që e përbënin atë, shumica dërmuese e njerëzve në Kosovë përqafuan një lëvizje të gjerë shoqërore për rezistencë paqësore ndaj politikave shtypëse të shtetit të Serbisë. Lëvizja paqësore e Kosovës, që zgjati për gati një dekadë, erdhi në jetë mbi themele morale te traditës dhe u përshkua nga etika e solidaritetit. Në këtë punim, do të bëjë një analizë mbi tri praktika të veprimit etik dhe afektiv të mishëruara në aktivitetet e njerëzve të zakonshëm në këtë periudhë – praktikat e faljes, dëgjimit dhe pritjes. Pra, argumenti kryesor i këtij punimi, do të jetë të provojë se shkalla e ngritur e veprimit etik ishte qenësore për ngjizjen dhe jetën e lëvizjes paqesore.
PERAN PEMERINTAH DAN MASYARAKAT DALAM MEMPERTAHANKAN PERAYAAN TRADISI 10 MUHARRAM DI DESA MEKAR JAYA KECAMATAN MERBAU MATARAM KABUPATEN LAMPUNG SELATAN
Authors: Susanti Agus , Rahmatika Zahra
Published: July 2024

Program pengabdian kepada masyarakat dalam bentuk perayaan semarak 10 muharram 1445 H ini dilaksanakan atas dasar kerjasama dosen dan mahasiswa Universitas Islam Negeri Raden Intan Lampung dengan pejabat dan masyarakat desa Mekar Jaya Kecamatan Merbau Kabupaten Lampung Selatan Provinsi Lampung dalam upaya merayakan 10 muharram sekaligus mempertahankan nilai Islami dan membangkitkan semangat anak-anak di desa Mekar Jaya dalam belajar mengaji. Metode yang digunakan ialah dengan mengadakan lomba kepada anak-anak desa Mekar Jaya yaitu seperti lomba MTQ, lomba adzan,dll yang diselenggarakan di aula masjid Al-Mujahidin Desa Mekar Jaya. Tujuan pengabdian ini ialah sebagai wadah untuk mempertahankan perayaan tradisi, memotivasi dan menambah wawasan keagamaan dan kepercayaan diri bagi peserta agar giat dalam menghafal dan juga belajar Al-Qur’an. Perayaan tradisi 10 muharram yang bersifat tradisional sampai sekarang masih tetap eksis dan bertahan di kalangan masyarakat Desa Mekar Jaya. Bertahannya perayaan tradisi 10 muharram di kalangan masyarakat muslim yang sudah modern sampai sekarang di Desa Mekar Jaya karena adanya peran pemerintah daerah Desa Mekar Jaya yang ikut serta melestarikan perayaan tradisi tersebut yaitu dengan cara menjadikan agenda tahunan. Penulis mengucapkan banyak terimakasih kepada masyarakat Desa Mekar Jaya Kecamatan Merbau Mataram Kabupaten Lampung Selatan karena mereka sudah ikut serta dalam kegiatan perayaan tradisi 10 muharram yang diadakan oleh dosen dan mahasiswa Universitas Islam Negeri Raden Intan Lampung.
Aligning College Curriculums with Business Needs: A Strategic Management Perspective
Authors: Ellis Matthew
Published: July 2024

This paper deals with the uncertainty of how colleges and universities are strategically adapting their current curriculums to meet the real-world business requirements and expectations of students who are entering the workforce. It addresses the question of how well university curriculums are faring to business requirements and the variance between college and the real world. The research was conducted by reviewing the literature of past research articles that had conducted a similar study to obtain information and process it to an application to the University of Alaska Fairbanks (UAF) College of Business and Security Management. It finds that Colleges are adapting to the ever-changing business environment and the world in the modern age around the nation by monitoring the needs and expectations of businesses of the students entering the workforce to further prepare and ensure that the students are adequately prepared for their new jobs. The research findings imply that other students can benefit from the research by sticking to the end and obtaining their degree and obtaining the benefits of knowledge, experience, networking, and friendships along the way.
Identifying sequential differences between protein structural classes using network and statistical approaches.
Authors: Wan Xiaogeng , Tan Xinying
Published: July 2024

Protein sequence information are believed to embed the hint of their structures. In this study, we motivate to use network and statistical approaches to identify the sequential differences between different protein structural classes and between different structural motifs. By examine significant amino acid feature interactions and statistical distributions of feature series, both common and special characteristics are identified for the different protein structural types. Analyses suggest that all top protein structural classes of CATH and SCOP show Leu, Val, and Asn as the sources of strong feature interactions, while Cys, His, Trp, and Met exhibit weak intra-type interactions with other features. There are also significant interactions between amino acids features such as Ala and -helix and bend preference, Ala and side-chain size, Ala and Gly, and Met and Leu. These phenomena are observed in all structural classes, which are assumed to have little influences in distinguishing the different structures. In  structures, Glu, Pro and side-chain size, hydrophobicity exhibit high importance in feature interactions, while in  structures, Gly, Thr and physical properties such as -helix and bend preference, extended structural preference, pK-C value and surrounding hydrophobicity for  structures show high importance in feature interactions. When comparing between the  and  structures, both types of structures show Ser as the common sources of feature interactions. The mixed  and  structures not only present common feature interactions with  and  structures, but exhibit special interactions between Met, Lys and double-bend preference property, and between the sequence arrangements of Cys, His, Met, Tyr and amino acid composition features. The intrinsically disordered proteins (IDPs) tends to present repetition patterns for a same kind of amino acids in high frequency Kmers, while the nine typical types of structural motifs also show different characteristics. Different value ranges are also found for different structural types according to statistical tests. The outcomes of this comparison study not only help to illuminate the mechanism of amino acid feature interactions in different types of structures, but also help us gain deeper understanding on how protein sequence influence structures.
Volunteer activities in the Udmurt Republic in the context of socio-political and cultural events of our time
Authors: I. K. Kudryavtseva ,   Udmurt Institute of History, Language and Literature, UdmFRC UB of the RAS
Published: July 2024

Volunteering can rightfully be considered as an institution of Russian civil society. Every year, the volunteer activities of caring people make a huge contribution to the socio-economic development of the regions and the country as a whole. In turn, civic activity and volunteer initiatives are supported and regulated by the state through the adoption of laws and separate regulatory legal documents. The key tool for popularizing volunteerism in the country is the portal dobro.ru, created by order of the Government of the Russian Federation, where information about current volunteer vacancies, ongoing and completed projects, and results achieved is posted. Researchers offer many classifications of volunteer activities: by purpose or direction (social, medical, etc.), by age composition (youth, “silver”, etc.), by temporary employment (temporary, permanent, etc.), by information technology ( online, offline), etc. This article examines the main directions of the volunteer movement in Udmurtia, identifying specific events held with the participation of volunteers, their contribution to the organization of charitable, cultural, educational, and patriotic forums. An integrated approach made it possible to consider the legal, social, active, personal aspects of the development of volunteerism in the Udmurt Republic. The work used the methods of semi-structured interviews, observations, and comparisons.
Credit Risk Assessment Using a Combined Approach of Supervised and Unsupervised Learning
Authors: Xu Tianyi
Published: July 2024

In the financial industry, credit scoring is a crucial tool for assessing credit risk. The study aims to enhance the accuracy and reliability of credit scoring by combining supervised and unsupervised learning methods. We propose an integrated model that combines Kohonen's Self-Organizing Maps (SOM) with the Random Forest algorithm to provide a more comprehensive analysis of credit card user data. Key features for model training were identified through feature selection and extraction. Experimental results show that the integrated model improved the AUC from 0.82 to 0.89, increased user satisfaction from a score of 3.8 to 4.35, and boosted usage rates by 12.5%. Additionally, the integrated model significantly enhanced the discrimination and prediction accuracy of user credit risk. These findings indicate that the combination of unsupervised learning with Kohonen's Self-Organizing Maps and supervised learning with Random Forest can effectively improve the accuracy of credit scoring, providing financial institutions with a more reliable tool for credit risk assessment.
A interdisciplinaridade filosófica no ensino médio
Authors: Oliveira Wellington Costa de , Figueiredo Diane Aparecida , Santos Saulo Magno Firmo
Published: July 2024

O presente trabalho é resultado de um estudo que busca compreender a interdisciplinaridade do ensino da filosofia no Ensino Médio. Partindo da premissa que filosofia no ensino médio tem o objetivo de despertar o aluno para um novo olhar do mundo que o circunda, e, que a disciplina de filosofia não traz respostas prontas, ao contrário, deve estimular ao aluno a perguntar-se e a questionar-se sobre a realidade. Enfatiza-se, portanto, que é na instituição de ensino que devem ser desenvolvidas as atitudes ligadas ao pensamento, de forma que o indivíduo possa se colocar no espaço e no tempo em que vive de maneira efetiva para si e para o grupo que o cerca. Por essa ótica, faz-se necessário observar que o conteúdo de Filosofia não deve ser objeto de memorização de datas, filósofos e fragmentos de pensamentos, mas deve ser um exercício constante do pensar e refletir. Esse artigo trata do ensino de Filosofia numa perspectiva interdisciplinar e seu objetivo é refletir sobre a eficácia dessa metodologia.
Alfabetização Uma revisão dos métodos e a perspectiva histórico – cultural
Authors: Souza Anne Mariette Alves Costa , Castro Rafael Fonseca de
Published: July 2024

O presente artigo é fruto de uma pesquisa de mestrado em andamento, cujo objetivo é realizar um breve histórico da Alfabetização no Brasil, abordando os principais métodos de alfabetização convencionalmente utilizados, para então, defender a abordagem teórico-metodológica escolhida, a Teoria Histórico-Cultural da Atividade (CHAT), que vem embasando pesquisas teóricas e experimentais, levando a um novo entendimento acerca da origem e da estrutura das funções psíquicas superiores humanas. Ao longo do texto, estabelecemos relações entre o processo de alfabetização, e os pressupostos da CHAT, mostrando que através da produção de conhecimentos científicos e práticas inovadoras de relevância social, a teoria traz imensurável contribuição à Educação.
Artificial intelligence-aided rational design and prediction model for progesterone-loaded self-microemulsifying drug delivery system formulations
Authors: Aumklad Porawan , Suriyaamporn Phuvamin , Panomsuk Suwanee , Pamornpathomkul Boonnada , Opanasopit Praneet
Published: July 2024

Artificial intelligence (AI) is now applied across various domains in nanomedicine. Self-microemulsifying drug delivery systems (SMEDDS) are isotropic mixtures of active compounds that can produce spontaneous oil-in-water emulsions. SMEDDS can improve the solubility of lipophilic drugs such as progesterone (PG). However, the physicochemical properties of SMEDDS are sensitive to various factors, depending on their components. This study generated a prediction model algorithm for PG-loaded SMEDDS to provide appropriate droplet size (DS), polydispersity index (PDI), zeta potential (ZP), and % drug loading (%DL). Various machine learning algorithms were compared for their accuracy, as reported by root mean square error (RMSE) and coefficient of determination (R2). The selected machine learning algorithms were implemented with an unseen training dataset, and the model performance was re-evaluated. The correlation of each factor was investigated. Self-micro emulsifying (SME) time, cloud point, pH, and viscosity of predicted PG-loaded SMEDDS were evaluated. Results showed that linear regression algorithms gave the highest accuracy and optimal prediction performance with the highest RMSE and R2. All components of PG-loaded SMEDDS correlated with DS, PDI, ZP, and %DL. The physical properties of predicted PG-loaded SMEDDS showed SME time within 39 s, cloud point at around 71.3 °C, pH between 5.53 and 6.10, and viscosity between 10.32 and 14.23 cP. This research outlined the application of a machine learning algorithm to build a prediction model to optimize PG-loaded SMEDDS drug delivery formulations.
THE PROBLEM OF THE RELATIONSHIP BETWEEN EMOTION AND INTELLIGENCE IN PSYCHOLOGY
Authors: Alışanlı Aytən
Published: July 2024

The article examines the scientific, theoretical and practical significance of the problem of interaction between emotions and intelligence in psychology. From the stage of formation of psychology to the present day, the process of studying the problem is fundamentally traced and analyzed over a wide historical period. At the same time, after the formation of the concepts “social intelligence”, “practical intelligence”, “emotional intelligence” in psychological thought, the emergence of various models of emotional intelligence, important points, general and various aspects of new approaches related to the practical significance of the interaction between cognitive and emotional-affective spheres. In the article, when analyzing the modern understanding and assessment of the problem, special attention is paid to issues that are of great importance for explaining a number of mental processes.
Hubungan Antara Psychological Well Being Dengan Work Life Balance Pada Dewasa Awal Yang Bekerja Di Kecamatan Babelan
Authors: Nazla Tazkiya , Yuliana Yomima Viena
Published: July 2024

Introduction: This research describes the relationship between Psychological well-being and work-life balance in early adults who work in Babelan District
Methods: This research uses quantitative methods, which use studies of correlation tests. The population that the researchers used for the research was the early adults who work in babelan district. Sampling using is convenience sampling technique. This study has 100 respondents that will be used by researchers. The measuring instruments used in this study are the Psychological well-being scale and the modified Work life balance scale.
Results: According to Pearson correlation analysis, the correlation coefficient value is 0.782, this value refers to the positive influence between Psychological well-being and Work-life balance.  The positive value indicates that the higher the value of Psychological well-being, the higher the Work-life balance, and vice versa, the lower the Work-life balance, the lower the Psychological well-being. The correlation test results have a value of 0.782 or can be interpreted as 78.2%, this value explains that Psychological well-being as an independent variable has a relationship with Work-life balance as the dependent variable of 78.2%, and the remaining 21.8% is influenced by other factors not explained in the study.
Conclusion and suggestion: Stating the alternative hypothesis is accepted. The higher the level of Psychological well-being, the higher the Work-life balance, and the lower the level of Work-life balance, the lower the Psychological well-being.
“Steganography”- Data Hiding Using Image Object
Authors: Kumbhekar Saurabh D
Published: July 2024

Abstract— Due to a vast increase in security breaches and other violations, Data hiding has become a vital measure for the protection of the integrity of an individual or a group. Image steganography is a perfect technique that exists for the protection of data from getting altered and getting safely transmitted. Steganography serves as an excellent method to secure information as the unauthorized party barely recognizes the secret message or a text that is hidden behind the original or the cover image. In this project we have mainly focused on the Least Significant Bit (LSB) for hiding the texts behind the images and build our idea through a GUI. LSB is quiet simple and an efficient algorithm in which the least significant bit that barely changes the quality or the build of the original image is changed and is replaced by the secret text that we want to communicate to the other users. The records of leak of touchy facts on structures has a critical chance to company facts being protection. Statistics display that the mistaken encryption of documents and communication because of human mistakes is one of the main reasons for records loss. The fast improvement of facts through made it simpler to ship the facts correctly and quicker to the vacation spot There are many transmission media to switch the facts to vacation spots like e-mails, at the identical time, its miles can be simpler to adjust and misuse the treasured records through hacking. Steganography refers documents as the quilt report to cover any other virtual report that consists to the fact that it is being transmitted. This project using to follow steganography using LSB algorithm after which the output of the encrypted image using a clustering to offer a photo steganography to offer a protection layer to that file. Keywords – Data Hiding; Least Significant Bit; Data Security; Image Steganography.
De-biasing Criminal Investigation
Authors: Gore Aaditya , Parasar Prof. (Dr.) Anuradha
Published: July 2024

Policing and Criminal Investigation in the present age must necessarily move towards more humane forms that avoid physical torture to extract truth from suspects. Criminal investigation consists of fact-finding based on certain factual theories formed by the investigator in order to arrive at the best possible explanation. Childhood socialisation has an invariable effect on the manner in which an individual perceives matters requiring cognitive problem-solving skills which even training cannot fully align into uniformity. Police departments recruit from different backgrounds: urban, semi-urban and rural. Differential socialisation among police personnel implies differential investigative approaches to similar criminal cases. This paper seeks to understand from the literature in the field, the possible solutions to investigative bias induced by differential socialisation as also the need for instituting in a reasonable system of criminal defence investigation so as to achieve better Police human resource management and to ensure better delivery of justice.
Smart Grid-based conceptualization and approach to a safety device for underground mines
Authors: Elia Martínez Torres Rosa , María Huerta González Juana , Alfredo Pineda Martínez
Published: July 2024

Considering the contributions of Artificial Intelligence in terms of human learning, it is proposed as applied research, the conceptualization to build a Technological Development that through atmospheric measurements in confined spaces, such as underground mines, ensures the well-being of the crews of personnel who operate according to the progress in the tunnels and are facing emissions of toxic gases.  putting their health and even their lives at risk. The objective is to present the theoretical and methodological bases to build a technological development that allows measuring and deploying information to the crews in situ and, remotely to the control office, which allows prevention, rescue and immediate medical attention reactions if necessary, sending information through networks called Smart Grid, which expand the literary and response capacity.  through attended events. It is envisaged as a safety device provided by the mining unit to the field, which can be a complement to the personal rescuers who are part of the miners' personal protective equipment (PPE), according to legislation in Mexico.
De la fenomenología de la voluntad al primado de la persona en la acción. A. Pfänder y L. Polo
Authors: Sánchez León Alberto
Published: July 2024

Tanto Pfänder como Polo han hecho unos estudios dignos de mención en lo que a la ética se refiere. Queremos rescatar en este breve trabajo lo mejor de estos pensadores que desde perspectivas y métodos muy dispares abordan temas y resuelven problemas de modos muy distintos llevándonos, cada uno a su manera, al puerto seguro del ser personal. Dichos pensadores nos muestran que, tanto con el método de la fenomenología realista como con el método poliano del abandono de la presencia, se puede entrever e incluso fundamentar el primado del ser personal en la acción humana.
Сихів: простори, пам'яті, практики
Authors: Отріщенко Наталя , Мисак Наталя , Склокіна Ірина , Одинець Світлана , Барб'єрі Анна , Беновська Марія , Бурса Отакар , Васюков Євгеній , Ґленті Дімітра , Дамергам Оскар , Йовановіч Єліца , Кемпінський Кацпер , Кочкова Яна , Ліцкєвіч Йоанна , Мандзик Тетяна , Онопченко Алла , Страшинська Аляксандра , Ткаченко Олексій , Цупко Ганна , Шупшинскас Матас
Published: July 2024

Ця книга – результат двотижневого дослідження під час роботи літньої школи про планову урбанність, яку три роки поспіль проводив Центр міської історії. Автори та авторки текстів намагалися охопити найрізноманітніші аспекти життя Сихова: його перетворення внаслідок міграцій людей та переміщення капіталів, зміни символічного ландшафту, трансформацію ролі водних ресурсів, спогади дитинства, практики городництва, дозвілля, споживання та спорту.
Підзамче: місця і простори
Authors: Бондаренко Андрій
Published: July 2024

Мета проекту — представити на карті "Інтерактивний Львів" особливості та головні моменти історичного розвитку кількох ділянок північно-східної частини Львова, об'єднаних назвою Підзамче.
Модернізм у Львові
Authors: Богданова Юлія
Published: July 2024

На цій карті представлені 23 вибрані будинки — об'єкти функціоналізму — спадщини, що досі у Львові є дещо суперечливою і недооціненою. Їхні історії розповідають про воєнні знищення та відбудову у місті, економічну кризу, нові вимоги щодо якості життя і житла. Вони були створені у взаємодії чи, іноді, протидії між архітекторами які розвивали нові сміливі ідеї, міською владою що провадила власну політику щодо розвитку міста, а також забудовниками і мешканцями.
Histomorphological Pattern of Fallopian Tube Lesions in a Tertiary Care Hospital
Authors: T Jannat , R Jeba , MS Nahid , MM Ahsan
Published: July 2024

wide range of diseases varying from salpingitis to malignancy can affect fallopian tubes. Fallopiantube lesions are associated with infertility. Moreover, Tubal epithelium (mainly fimbria) is apotential origin of ovarian and peritoneal carcinoma.Objective: The present study was designed to evaluate the histomorphological patterns as well asthe frequency of different fallopian tube lesions.Method: A total of 300 cases of fallopian tubes were included in this study according to inclusionand exclusion criteria. After receiving gross examination was done and relevant data were collectedin preformed proforma. Tissue processing, paraffin block preparation, and hematoxylin and eosin(H&E) stain were done according to standard protocol followed by the Pathology Department ofDMC. Sections were examined by light microscopy.Results: From this study, it was stated that pathological lesions of fallopian tubes were observed in40% of cases which was a large number. Most of the lesions of fallopian tubes were non-neoplasticand very few neoplastic lesions were found. Most of the lesions occur at 31-40 years of age. Totalabdominal hysterectomy with bilateral salpingo-oophorectomy was the most common type ofspecimen and fibroid uterus was the most common surgical indication (60 cases 20%) followed byovarian cyst (53 cases 17.66%). Salpingitis was the most common histopathological diagnosis,found in 47 (15.66%) cases followed by ectopic tubal pregnancy (13.33%). Primary malignancywas found in only a single patient.Conclusion: It is necessary to do a thorough examination of fallopian tubes and give at least oneblock from each site. It is not only for the detection of tubal pathology but also to detect precursorlesions of the tubal epithelium (mainly fimbria) as it is the origin of ovarian or peritonealcarcinoma
Association between Histomorphological Types of Hydatidiform Mole and the Expression of Ki67 Immunohistochemical Marker as well as β-hCG Level Status
Authors: S Hossain , R Jeba , ZB Khan
Published: July 2024

disease which is sub-classified into complete hydatidiform mole (CHM) and partial hydatidiformmole (PHM). Accurate subclassification of HM is very important as the development ofchoriocarcinoma and persistent trophoblastic diseases are more related to CHM than PHM.However, sometimes this subclassification is more challenging only based on histomorphologicalfindings. Because there is considerable intraobserver and interobserver variability,histomorphological findings in conjunction with some complementary methods such asimmunohistochemistry and biochemical markers could be helpful in the accurate interpretation ofthe HMs. The aim of this study was to evaluate the expression of Ki 67 immunostain along withthe pretreatment β-hCG level and to identify their association with histomorphological types ofhydatidiform mole.Methods: This cross-sectional observational study was done at Department of Pathology, DhakaMedical College. The cases were classified into CHM and PHM based on histopathologicalfeatures. Pretreatment β-hCG level noted and Ki 67 immunohistochemistry was done. The resultsof the cases were collected and tabulated. Statistical analysis was performed on the tabulated datausing Fisher Exact test, Chi-square test and Unpaired t-test.Results: Out of 50 cases, based on histopathological criteria, 27(54.0%) cases were CHM and23(46.0%) were PHM. After evaluating Ki67 immunohistochemical staining, among CHM,23(85.2%) cases showed Ki67 score-3 and 4(14.8%) cases score-2. Out of 23 PHM, 22 (95.7%)cases showed Ki -67 score-2 and 1(4.3%) case showed score-3. These were statistically significant.On the other hand, among the CHM 22 (81.5%) had β-hCG level ≥100000 mIU/ml and 5 (18.5%)had <100000 mIU/ml. Among PHM 2 (8.7%) had β-hCG ≥ 100000 mIU/ml and 91.3% had β-hCG<100000 mIU/ml. It was also statistically significant.Conclusion: Diagnosis of HM can be improved by Ki67 labeling index and evaluation ofpretreatment β-hCG level, which will help in differentiating CHM from PHM. The correctdiagnosis is crucial for future treatment and follow-up of the patients.
Experiencia y lucha de un superviviente de mutilación ocular por balas de goma
Authors: Guillot Carles
Published: July 2024

Mi nombre es Carles Guillot y tengo 51 años. El 17 de julio del año 2001, hace ahora 23 años, en un contexto de protesta contra el asalto y desalojo ilegal de una casa okupada, la Kasa de la Muntanya, un policía nacional me disparó a bocajarro en la cara y me produjo el estallido del globo ocular derecho. Como que el barrio estaba tomado por la policía, tuvimos que esperar unas horas para poder ir a un centro hospitalario. Finalmente, unas compañeras me llevaron al Hospital de Bellvitge, el hospital más lejano de la zona, para evitar ser identificado por las fuerzas del orden. Allí el pronóstico fue claro. Quedaría tuerto para toda la vida.
Enhancement of Breast Cancer Chemotherapy and Radiotherapy Responses by Modulation of Ferroptosis
Authors:   , Alzufairi Alaa Awad
Published: July 2024

Breast cancer is the most common cancer in women in the UK. Surgery, radiotherapy, hormone therapy and chemotherapy are all current therapies. The success rate of chemotherapy and radiotherapy are affected by intrinsic insensitivity, and acquired resistance, and novel chemo-sensitisation and radio-sensitisation strategies are currently being researched. Ferroptosis is an iron-dependent program cell death pathway characterised by massive accumulation of reactive oxygen species. Reactive oxygen species accumulation and subsequent lipid peroxidation-mediated death is Fe2+-dependent, leading to a form of cell death that is distinct from apoptosis. Since it is known that both chemotherapy and radiotherapy exert some ferroptosis-mediated effects, it was hypothesised that chemotherapy responses and radiotherapy responses would be enhanced by co-treatment with ferroptosis inducers. To test the co-treatment with ferroptosis inducers in a disease relevant model, both 2D standard cell culture and 3D tumour spheroids in two breast cancer cell lines were assessed. Ferroptosis inducers affected MDA-MB-231, but not MCF-7. Ferroptosis inducers did not have a robust enhancement of Doxorubicin responses, although more promising responses were observed with Cisplatin but only in MDA-MB-231 and only in 2D cell culture, not in spheroids. Since ferroptosis is controlled in-part by Nrf2, the Nrf2-inhibitor ML385 was tested, which partially enhanced chemotherapy responses, and also identified a specific drug combination vulnerability when combined with the ferroptosis inducer RSL3, whereby MDA-MB-231 cells did not respond potently to RSL3 plus Doxorubicin, but were sensitive when ML385 was added. This was not observed in MCF-7. In spheroids, responses to RSL3 were heterogeneous in that adjacent spheroids showed differential responses to RSL3, which is a novel finding and may identify a resistance mechanism. Radiotherapy responses were not robustly enhanced by ferroptosis inducers. Despite the being a strong theoretical case for combining ferroptosis inducers with chemotherapy or radiotherapy, responses in these two cell lines were promising at times, but data does not strongly support further study in pre-clinical models.
Tino Casal: pastiche y posmodernidad en el pop español
Authors: Costa Gálvez Lola
Published: July 2024

«Oro negro», «Alas en los tacones» o «Champú de huevo». Estos son los títulos de algunas de las canciones de Tino Casal. El Centro Asociado de Asturias de la Universidad Nacional de Educación a Distancia (UNED) organiza un curso del 22 al 24 de julio de 2024 dedicado al icónico artista asturiano. Hablamos con Fernan del Val, profesor de la Facultad de Ciencias Políticas y Sociología de esta universidad y director del curso.
¿Cómo puede ayudar la IA generativa en la organización de eventos? (I)
Authors: Estanyol i Casals Elisenda
Published: July 2024

La inteligencia artificial (IA) generativa puede ayudar en la organización de eventos corporativos personalizando experiencias para los asistentes, automatizando tareas de gestión y analizando el feedback de los participantes en tiempo real. Aun así, plantea retos y genera incertidumbres en el ámbito profesional, sobre los que los estudiantes de la asignatura Organización estratégica de eventos del Máster universitario de Comunicación Corporativa, Protocolo y Eventos han estado reflexionando este semestre.
Las organizaciones no gubernamentales y sus influencias lobbying: clima e inmigración
Authors: Oliver-González Ana Belén
Published: July 2024

Objetivo: estudiar cómo actúan las ONG y demostrar las influencias lobbying que ejercen estos grupos de presión sobre el medioambiente y a favor de la inmigración producida por el cambio climático.
Metodología: Cualitativa, a través de la observación directa sobre el complejo mundo del lobby, permitiendo profundizar en las influencias que ejercen los grupos de presión y de interés para concienciar a la ciudadanía sobre las consecuencias que está provocando el cambio climático a nivel global, en especial, en aquellas poblaciones más vulnerables a estos notables cambios.
Resultados: Nos enfrentamos a una grave crisis energética global, especialmente en Europa, a raíz de la invasión rusa de Ucrania, la explosión demográfica de los países subdesarrollados, el hambre y el cambio climático que afecta a la disponibilidad de los recursos naturales, fenómenos meteorológicos extremos que están desplazando a millones de personas de sus hogares. Estas migraciones climáticas tienen un fuerte impacto en la seguridad alimentaria, en la salud y la economía de los lugares de origen como en los lugares de acogida. Las Organizaciones No Gubernamentales (ONG) entienden la importancia de abordar las causas del cambio climático y trabajar para minimizar impacto en las personas, especialmente en las desplazadas medioambientales. Las conclusiones corroboran la hipótesis planteada de que las ONG ejercen un fuerte lobby a través de campañas mediáticas para concienciar, presionar e influenciar, tanto en la sociedad civil como en los tomadores de decisiones.
Limitaciones:  Tratar de seleccionar entre la amplia bibliografía existente, aquella que tratase de manera específica la noción del lobby aplicado a las ONG, ya que la literatura sobre el tema es amplia, pero son estudios de conjunto que salvan sin profundizar, el objeto de este estudio
Códigos JEL: F22; F53; O19.
Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females
Authors: Patton Megan E , Kelekar Sherwin , Taylor Lauren J , Dean Angela E , Zuo Qianying , Thakare Rhishikesh N , Lee Sung Hwan , Gentry Emily , Panitchpakdi Morgan , Dorrestein Pieter , Alnouti Yazen , Madak-Erdogan Zeynep , Lee Ju-Seog , Finegold Milton J , Anakk Sayeepriyadarshini
Published: July 2024

Hepatocellular carcinoma (HCC), the most common liver cancer, exhibits a higher incidence in males. Here, we report that mice lacking the bile acid regulators, Farnesoid X Receptor (FXR) and Small Heterodimer Partner (SHP), recapitulate the sex difference in liver cancer risk. Since few therapeutic options are available, we focused on understanding the intrinsic protection afforded to female livers. Transcriptomic analysis in control and FXR and SHP double knockout livers identified female-specific changes in metabolism, including amino acids, lipids and steroids. We examined if the obtained transcriptomic signatures correlate with the survival outcomes for HCC patients to assess the translational potential of this murine HCC model. Gene signature that is unique to the knockout females correspond with low-grade tumors and better survival. Ovariectomy blunts the metabolic changes in female livers and promotes tumorigenesis that, intriguingly, coincides with increases in serum bile acid (BA) levels. Despite similar genetics, we found higher serum BA concentrations in males, whereas female knockout mice excreted more BAs. Decreasing enterohepatic BA recirculation using cholestyramine, an FDA-approved resin, dramatically reduced the liver cancer burden in male mice. Overall, we reveal that sex-specific BA metabolism leading to lower circulating BA concentration protects female livers from developing cancer. Thus, targeting BA excretion may be a promising therapeutic strategy against HCC.
Reproducible, data-driven characterization of sleep based on brain dynamics and transitions from whole-night fMRI
Authors: Yang Fan Nils , Picchioni Dante , de Zwart Jacco A , Wang Yicun , van Gelderen Peter , Duyn Jeff H
Published: July 2024

Understanding the function of sleep requires studying the dynamics of brain activity across whole-night sleep and their transitions. However, current gold standard polysomnography (PSG) has limited spatial resolution to track brain activity. Additionally, previous fMRI studies were too short to capture full sleep stages and their cycling. To study whole-brain dynamics and transitions across whole-night sleep, we used an unsupervised learning approach, the Hidden Markov model (HMM), on two-night, 16-hour fMRI recordings of 12 non-sleep-deprived participants who reached all PSG-based sleep stages. This method identified 21 recurring brain states and their transition probabilities, beyond PSG-defined sleep stages. The HMM trained on one night accurately predicted the other, demonstrating unprecedented reproducibility. We also found functionally relevant subdivisions within rapid eye movement (REM) and within non-REM 2 stages. This study provides new insights into brain dynamics and transitions during sleep, aiding our understanding of sleep disorders that impact sleep transitions.
Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ
Authors: Shang Jinsai , Kojetin Douglas J
Published: July 2024

Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor transcription factor that regulates gene expression programs in response to ligand binding. Endogenous lipids and synthetic ligands, including covalent antagonist inhibitors such as GW9662 and T0070907, are thought to compete for the orthosteric pocket in the ligand-binding domain (LBD). However, we previously showed that synthetic PPARγ ligands can cooperatively cobind with and reposition a bound endogenous orthosteric ligand to an alternate site, synergistically regulating PPARγ structure and function (Shang et al., 2018). Here, we reveal the structural mechanism of cobinding between a synthetic covalent antagonist inhibitor with other synthetic ligands. Biochemical and NMR data show that covalent antagonist inhibitors weaken—but do not prevent—the binding of other synthetic ligands via an allosteric mechanism rather than direct ligand clashing. The covalent ligands shift the LBD ensemble toward a transcriptionally repressive conformation, which structurally clashes with and reduces the orthosteric binding affinity of non-covalent synthetic ligands. Crystal structures reveal different non-covalent synthetic ligand-specific cobinding mechanisms ranging from alternate site binding to unexpectedly adopting an orthosteric binding mode by altering the covalent ligand binding pose. Our findings not only highlight the significant flexibility of the PPARγ orthosteric pocket and its ability to accommodate multiple ligands simultaneously, but also demonstrate that GW9662 and T0070907 should not be used as reliable chemical tools to inhibit the binding of other ligands to PPARγ.
Comparing and characterizing scapular muscle activation ratios in males and females during execution of common functional movements
Authors: Lang Angelica E. , Chorneyko Annaka , Heinrichs Vivian
Published: July 2024

Background

The shoulder complex relies on scapular movement controlled by periscapular muscles for optimal arm function. However, minimal research has explored scapular muscle activation ratios during functional tasks, nor how they might be influenced by biological sex. This investigation aims to characterize how sex impacts scapular muscle activation ratios during functional tasks.

Methods

Twenty participants (ten females, ten males) were assessed with surface electromyography (EMG) and motion tracking during seven functional tasks. Activation ratios were calculated from normalized EMG for the three trapezius muscles and serratus anterior. Scapular angles were calculated using a YXZ Euler sequence. Two-way mixed methods ANOVAs (p < .05) were used to assess the effects of sex and humeral elevation level on ratios and angles.

Results

Sex-based differences were present in the Tie Apron task, with males exhibiting higher upper trapezius/lower trapezius and upper trapezius/middle trapezius ratios than females. Males also demonstrated decreased internal rotation in this task. Other tasks showcased significant sex-based differences in scapular upward rotation but not in activation ratios. Humeral elevation generally demonstrated an inverse relationship with scapular muscle activation ratios.

Conclusions

This study highlights sex-based differences in scapular muscle activation ratios during specific functional tasks, emphasizing the need to consider sex in analyses of shoulder movements. Normative activation ratios for functional tasks were provided, offering a foundation for future comparisons with non-normative groups. Further research is warranted to confirm and explore additional influencing factors, advancing our understanding of shoulder activation and movement in diverse populations.
Estudo das áreas de Preservação Permanente de microbacia em Joinville/SC visando a regularização das ocupações pela legislação municipal
Authors: Oliveira João Paulo de , Perini Brayam Luiz Batista , Vieira Celso Voos , Franczak Priscila Ferraz , Maia Bianca Goulart de Oliveira
Published: July 2024

Em determinados contextos e sob regulamentações, a flexibilização controlada dos afastamentos pode ser uma ferramenta eficaz para legalizar habitações. No entanto, a manutenção das áreas de preservação permanente ao longo dos corpos d'água naturais contribuem com a preservação da qualidade da água, na conservação da biodiversidade e na mitigação de riscos de desastres naturais. Portanto, este estudo aplica metodologia que avalia a função ambiental dos corpos d’água urbanos e oferece uma visão equilibrada sobre a flexibilização dos afastamentos, para conciliar o desenvolvimento urbano com a conservação ambiental, visando o benefício tanto das comunidades urbanas quanto dos ecossistemas naturais. Em uma microbacia hidrográfica no município de Joinville, foi aplicada a metodologia instituída pela Lei Complementar n° 601/2022 de Joinville/SC como uma estratégia para promover a regularização fundiária em áreas urbanas situadas em Áreas de Preservação Permanente (APP). A pesquisa utilizou como metodologia o levantamento de dados geomorfológicos detalhados e a realização de simulações de matrizes de impactos ambientais. Conforme os resultados obtidos durante as simulações da matriz de impacto ambiental, observou-se que alguns aspectos ambientais não se encontram presentes em determinados trechos de corpos d’água naturais inseridos no ambiente urbano, que culminaram na conclusão da perda das funções ambientais, onde poderiam ser legalizadas as ocupações informais. Por outro lado, em outros trechos da microbacia foi determinada a  manutenção das áreas de preservação permanente ao redor de corpos d'água, entendida como crucial para proteger a qualidade da água, conservar a biodiversidade e reduzir o risco de eventos naturais.
Gestão e concepção dos projetos hidrossanitários integrados com os demais projetos elaborados na cidade de Goiânia-GO
Authors: Pitaluga Douglas Pereira da Silva , Silva Fernando José Araújo da , Amaral Letícia Leal
Published: July 2024

Os projetos de engenharia são importantes para evitar atrasos de entrega da obra, desprendimento de custos adicionais, bem como, as potenciais sequelas construtivas deixadas a terceiros. Almeja-se entender como as empresas localizadas na cidade de Goiânia se organizam durante o processo de elaboração dos projetos hidrossanitários em conjunto com os demais projetos, a fim de identificar a contribuição dos coordenadores de projetos e respectivos projetistas. A metodologia utilizada deu-se a partir de entrevistas realizadas com empresas projetistas da cidade, com vistas na coordenação dos projetos elaborados simultaneamente por projetistas de diferentes áreas. A partir da análise dos resultados obtidos, pôde-se identificar se existe um padrão quanto a elaboração dos projetos com vistas a identificação das fases pelas quais os projetos hidrossanitários passam durante sua concepção; enfatizando-se como funciona a comunicação entre os projetistas de diferentes identificando-se o reflexo da atuação dos coordenadores de projetos nos resultados das empresas. Constatou-se que empresas pesquisadas não possuem um coordenador de projetos dedicado exclusivamente à atividade, ao tempo que encontra dificuldades de estabelecer comunicação formal entre os projetistas das áreas envolvidas, bem como, não tem um padrão de projetos com fases de elaboração bem definidas, contudo, a maioria delas executam a compatibilização dos projetos com ferramentas 3D.