bluuebunny/crossref_metadata_2025 huggingface dataset:
User adaptation and ERP benefits: moderation analysis of user experience with ERP
Authors: Eid Mustafa Ismail Mustafa , Abbas Hani I.
Published: March 2017

Purpose

The purpose of the study is to measure the impact of user adaptation of enterprise resources planning (ERP) post implementation through an appreciation of the benefits ERP provides to its users in Saudi Arabia (SA). The study will also measure the moderation effect of user experience with ERP on the relationship between user adaptation of ERP and user benefits from ERP.

Design/methodology/approach

The authors conducted a survey questionnaire study of 253 ERP users and tested the research model through the application of a hierarchical multiple regression analysis.

Findings

The findings show that user adaptation of ERP has a strong positive impact on ERP user benefits. In addition, it is found that the level of user experience with ERP has no significant moderation effect on the relationship between user adaptation of ERP and ERP user benefits.

Practical implications

The study findings suggest that functional management should develop appropriate strategies to effectively manage user adaptation of ERP. An equally important implication is for the ERP vendors to consider making their ERP systems as flexible and maintainable as possible by offering effective tools to easily accommodate changes in user requirements with minimum effort and cost.

Originality/value

This study provides insights into the inter-relationships between the motivation for improving user adaptation of ERP and gaining more benefits from ERP systems. It will also extend our understanding of the moderation effect of user experience with ERP on the relationship between user adaptation of ERP and ERP user benefits in developing countries.
Social enterprise: a model of recovery and social inclusion for occupational therapy practice in the UK
Authors: Stickley Anna Joy , Hall Kelly J.
Published: March 2017

Purpose

Occupational therapists are increasingly working in organisations outside of the public sector. UK government policy over the past decade has promoted health and social care provision by social enterprises. The purpose of this paper is to examine the compatibility of occupational therapy practice and a social enterprise environment, within the UK and questions if this approach may enhance experiences of social inclusion for people who use these services.

Design/methodology/approach

Case study methodology was used with eight social enterprises in the UK. Data were collected through: semi-structured interviews, formal organisational documents, and field visits and observations. Interviews were conducted with 26 participants who were occupational therapists, service users and social entrepreneurs/managers. The interviews were recorded, transcribed and analysed using thematic analysis.

Findings

Occupational therapists experienced job satisfaction, professional autonomy and were able to practise according to their professional philosophy. Service users valued support with: employment, routine, social relationships, and developing a sense of identity, particularly outside of a medical model definition. To a degree therefore, people using these services claimed socially inclusive benefits. Challenges with funding social enterprises, however, impacted occupational therapy delivery in some cases.

Research limitations/implications

The majority of social enterprise research is drawn from case study methodology; however, this was the most appropriate research design to gain greatest insight into a small but developing phenomenon. Further research into occupational therapy practice within social enterprises is required, particularly on the effectiveness of returning to work and social inclusion.

Social implications

Social enterprises can provide therapeutic environments to promote recovery and social inclusion which is also compatible with occupational therapy practice.

Originality/value

This is the first known national research into occupational therapy provision in social enterprises within the UK, which evidences a compatibility within occupational therapy practice within a social enterprise environment and the benefits of this.
The collaborative assessment and management of suicide (CAMS): a recovery-oriented approach to working with suicidal people
Authors: Galavan Eoin , Repper Julie
Published: March 2017

Purpose

The collaborative assessment and management of suicide (CAMS) is an evidenced-based therapeutic framework designed to facilitate a co-authored and collaborative approach to addressing suicidality (Jobes, 2009). The collaborative nature of this approach is fundamental to its success in delivering suicide specific and recovery-oriented mental health care to thousands of suicidal people to date. The purpose of this paper is to outline the CAMS model and propose it as a recovery-oriented approach to addressing suicidality in mental health care.

Design/methodology/approach

The CAMS model and its philosophy are reviewed in light of recovery principles.

Findings

It is proposed that the CAMS model is consistent with a recovery-oriented approach to mental health care for suicidal people.

Originality/value

As yet there are no specifically identified recovery-oriented approaches to addressing suicidality.
Exploring the impact of peer support in early intervention in psychosis
Authors: White Hannah , Price Laura , Barker Tom
Published: March 2017

Purpose

Peer support (PS) has, over recent years, been implemented across a variety of NHS adult mental health settings. In November 2015, peer support workers (PSW) were introduced to an Early Intervention in Psychosis Service (EIS) in the Midlands. The purpose of this paper is to focus on organisational factors, asking how do PS impact on an early intervention in psychosis multi-disciplinary team (MDT).

Design/methodology/approach

Six EIS MDT members participated in an hour-long focus group. The data were analysed using thematic analysis, in line with a qualitative methodology (Braun and Clarke, 2006).

Findings

Two themes were generated, including “The values of PS” (consisting of three sub-themes: improving service engagement; personal qualities; and the peer relationship); and “The peer support role” (consisting of three sub-themes: living experience; boundaries; and alternative perspectives). Findings imply that PS in the current EIS related to: improved service engagement and greater understanding between service providers and users; which could be linked to better outcomes for service users (such as reduced duration of untreated psychosis (DUP)).

Originality/value

It has been suggested that PSWs facilitate an improved understanding between service providers and service users (Repper and Watson, 2012). However, research into organisational and team benefits of PS is lacking, with a need for more exploration (Repper, 2013). The current study begins to address the lack of literature regarding the organisational impact of PS, and even further regarding early intervention.
Temporal and spatial dynamics of Tomato spotted wilt virus and its vector in a potato crop in Argentina
Authors: Salvalaggio A.E. , López Lambertini P.M. , Cendoya G. , Huarte M.A.
Published: March 2017

The nature of spatial and temporal dynamics of Tomato spotted wilt virus (TSWV) and its vector in a potato crop cv. Innovator without insecticide application is analysed. Seed tuber was analysed for the presence of TSWV as a source of initial inoculum. The presence of plants with symptoms of TSWV was evaluated by visual observation and DAS‐ELISA analysis to confirm the virus infection. Thrips species were collected from leaves and inflorescences and identified under stereomicroscope. The distribution of symptomatic plants and thrips species was recorded five times at 14 days intervals. The initial seed tuber infection was of 1.1%. Disease incidence was 0% at 29 days after planting (DAP), 0.2% at 43 DAP, 2.2% at 56 DAP, 11.6% at 70 DAP and 14.6% at 84 DAP. The progress of the disease was adequately described by a Logistic model [y = 0.15/(1 + 1205372.93 × exp (−0.22 × DAP))]. Thrips vector species identified as resident in the crop during the whole cycle were Thrips tabaci (n = 423), Frankliniella occidentalis (n = 141) and as occasional species, F. schultzei (n = 34) and F. gemina (n = 5) were found. At 43 and 56 DAP a random distribution pattern was observed and the thrips species found were T. tabaci (n = 188) and F. occidentalis (n = 105). An aggregated pattern was determined at 70 and 84 DAP. Spatial patterns of the disease spread suggest a polycyclic epidemic with TSWV secondary spread in the potato crop. Multiple control measures were deduced from these epidemiological results like virus testing in tubers, removal of external virus infection sources and thrips control.
Managing workplace stress in community pharmacy organisations: lessons from a review of the wider stress management and prevention literature
Authors: Jacobs Sally , Johnson Sheena , Hassell Karen
Published: March 2017

Background

Workplace stress in community pharmacy is increasing internationally due, in part, to pharmacists’ expanding roles and escalating workloads. Whilst the business case for preventing and managing workplace stress by employers is strong, there is little evidence for the effectiveness of organisational stress management interventions in community pharmacy settings.

Aim

To identify and synthesise existing evidence for the effectiveness of organisational solutions to workplace stress from the wider organisational literature which may be adaptable to community pharmacies.

Method

A secondary synthesis of existing reviews. Publications were identified through keyword searches of electronic databases and the internet; inclusion and exclusion criteria were applied; data about setting, intervention, method of evaluation, effectiveness and conclusions (including factors for success) were extracted and synthesised.

Findings

Eighteen reviews of the stress management and prevention literature were identified. A comprehensive list of organisational interventions to prevent or manage workplace stress, ordered by prevalence of evidence of effectiveness, was produced, together with an ordered list of the benefits both to the individual and employing organisation. An evidence-based model of best practice was derived specifying eight factors for success: top management support, context-specific interventions, combined organisational and individual interventions, a participative approach, clearly delineated tasks and responsibilities, buy-in from middle management, change agents as facilitators and change in organisational culture.

Conclusions

This literature review provides community pharmacy organisations with evidence from which to develop effective and successful stress management strategies to support pharmacists and pharmacy staff. Well-designed trials of stress management interventions in community pharmacy organisations are still required.
Explaining individuals' justification of layoffs
Authors: Richter Manuela , König Cornelius J.
Published: March 2017

This research addresses why organizational downsizing, given its adverse impact on both organizations and individuals, continues to be a popular management practice. Drawing on system justification theory, we argue that individuals justify downsizing to preserve the legitimacy of the prevailing social‐political system. Across two studies, we surveyed a total of 527 employees and examined whether the perceived likelihood of downsizing, past experiences of layoffs, and the anticipation of future layoffs enhance individuals' justification of downsizing. We also took into account cognitive and motivational biases for justifying the status quo. Our results indicate that individuals' motivation to defend and justify downsizing may strengthen its stability within society, even though implications are largely negative for those involved.
Recent Literature Update on Medication Risk in Older Adults, 2015–2016
Authors: Koronkowski Michael J. , Semla Todd P. , Schmader Kenneth E. , Hanlon Joseph T.
Published: March 2017

Medications can pose considerable risk in older adults. This article annotates four articles addressing this concern from 2016. The first provides national data on the use of specific prescription, over‐the‐counter and dietary supplements in older adults and their change over time. The second discusses the opportunity of deprescribing ineffective/unnecessary stool softeners (i.e., docusate) routinely given to older hospital patients. The third national study examines common adverse drug events in older emergency room patients. Finally, a study published demonstrating a potential association between melatonin and fractures is discussed. This manuscript is intended to provide a narrative review of key publications in medication safety for clinicians and researchers committed to improving medication safety in older adults.
Progress Monitoring in Social Studies Using Vocabulary Matching Curriculum–Based Measurement
Authors: Lembke Erica S. , Allen Abigail , Cohen Daniel , Hubbuch Chris , Landon Dorothy , Bess Joy , Bruns Heather
Published: March 2017

Two hundred and two (n = 202) sixth–grade students in social studies were administered a weekly vocabulary–matching curriculum–based measure (CBM) for 35 weeks. Students were also administered the Scholastic Reading Inventory (SRI), along with the annual state high–stakes test in Communication Arts. CBM scores were analyzed with respect to alternate form reliability, validity with criterion measures, and student growth over time. Results suggest that the vocabulary–matching CBM is reliable and valid with the SRI but not with the state test. Students showed an overall linear trend of growth, but this growth was flat in the middle of the semester. Implications for research and practice are discussed.
Integrated omics analyses of retrograde signaling mutant delineate interrelated stress‐response strata
Authors: Bjornson Marta , Balcke Gerd Ulrich , Xiao Yanmei , de Souza Amancio , Wang Jin‐Zheng , Zhabinskaya Dina , Tagkopoulos Ilias , Tissier Alain , Dehesh Katayoon
Published: March 2017

To maintain homeostasis in the face of intrinsic and extrinsic insults, cells have evolved elaborate quality control networks to resolve damage at multiple levels. Interorganellar communication is a key requirement for this maintenance, however the underlying mechanisms of this communication have remained an enigma. Here we integrate the outcome of transcriptomic, proteomic, and metabolomics analyses of genotypes including ceh1, a mutant with constitutively elevated levels of both the stress‐specific plastidial retrograde signaling metabolite methyl‐erythritol cyclodiphosphate (MEcPP) and the defense hormone salicylic acid (SA), as well as the high MEcPP but SA deficient genotype ceh1/eds16, along with corresponding controls. Integration of multi‐omic analyses enabled us to delineate the function of MEcPP from SA, and expose the compartmentalized role of this retrograde signaling metabolite in induction of distinct but interdependent signaling cascades instrumental in adaptive responses. Specifically, here we identify strata of MEcPP‐sensitive stress‐response cascades, among which we focus on selected pathways including organelle‐specific regulation of jasmonate biosynthesis; simultaneous induction of synthesis and breakdown of SA; and MEcPP‐mediated alteration of cellular redox status in particular glutathione redox balance. Collectively, these integrated multi‐omic analyses provided a vehicle to gain an in‐depth knowledge of genome‐metabolism interactions, and to further probe the extent of these interactions and delineate their functional contributions. Through this approach we were able to pinpoint stress‐mediated transcriptional and metabolic signatures and identify the downstream processes modulated by the independent or overlapping functions of MEcPP and SA in adaptive responses.
Faecal Campylobacter shedding among dogs in animal shelters across Texas
Authors: Leahy A. M. , Cummings K. J. , Rodriguez‐Rivera L. D. , Hamer S. A. , Lawhon S. D.
Published: March 2017

Epidemiologic studies on faecal Campylobacter shedding among dogs in the United States have been limited, despite evidence that the incidence of human campylobacteriosis has increased over the last decade. Our objectives were to estimate the prevalence of faecal Campylobacter shedding among shelter dogs in Texas, to estimate the specific prevalence of Campylobacter jejuni and Campylobacter coli shedding, and to identify risk factors for Campylobacter‐positive status. Using a cross‐sectional study design, we collected faecal samples from dogs in six animal shelters across Texas between May and December, 2014. Quantitative PCR protocols were used to detect Campylobacter in samples and to specifically identify C. jejuni and C. coli. The prevalence of faecal Campylobacter shedding among sampled dogs was 75.7% (140/185). Prevalence varied significantly by shelter (p = .03), ranging from 57% to 93%. There was a marginal association (p = .06) between abnormal faecal consistency and positive Campylobacter status, after controlling for shelter as a random effect. However, approximately 70% of Campylobacter‐positive dogs had grossly normal faeces. Campylobacter prevalence did not vary significantly by age group or sex. The prevalence of C. jejuni‐positive samples was 5.4% (10/185), but C. coli was not detected in any samples. Dogs are a potential source of zoonotic Campylobacter transmission.
Herniation of a urinary bladder diverticulum: diagnosis and management of a fluctuating inguinal mass
Authors: Nabavizadeh Reza , Nabavizadeh Behnam , Hampton Lance J , Nabavizadeh Aliakbar
Published: March 2017

Inguinal herniation of a bladder diverticulum is a rare finding. The diagnosis should be suspected if the size of hernia is variable on urination. These patients may also experience obstructive voiding symptoms. Various imaging modalities may clarify the diagnosis. In our patient, intravenous urography precisely showed a bladder diverticulum in the right inguinal area. The patient underwent open simple prostatectomy and herniorrhaphy. He remains symptom-free on follow-up.
Elimination of Emergency Department Medication Errors Due To Estimated Weights
Authors: Greenwalt Mary , Griffen David , Wilkerson Jim
Published: March 2017

From 7/2014 through 6/2015, 10 emergency department (ED) medication dosing errors were reported through the electronic incident reporting system of an urban academic medical center. Analysis of these medication errors identified inaccurate estimated weight on patients as the root cause. The goal of this project was to reduce weight-based dosing medication errors due to inaccurate estimated weights on patients presenting to the ED. Chart review revealed that 13.8% of estimated weights documented on admitted ED patients varied more than 10% from subsequent actual admission weights recorded. A random sample of 100 charts containing estimated weights revealed 2 previously unreported significant medication dosage errors (.02 significant error rate). Key improvements included removing barriers to weighing ED patients, storytelling to engage staff and change culture, and removal of the estimated weight documentation field from the ED electronic health record (EHR) forms. With these improvements estimated weights on ED patients, and the resulting medication errors, were eliminated.
Suitability of jetted and grouted precast pile for supporting mast arm structures
Authors: Thiyyakkandi Sudheesh , McVay Michael , Lai Peter , Herrera Rodrigo
Published: March 2017

Jetted and grouted precast piles (JGPPs) are prefabricated piles installed utilizing jetting and pressure grouting. These piles are well-suited for urban environments as they overcome the inherent drawbacks of currently chosen deep foundations (e.g., noise and vibration disturbances due to pile driving, quality control issue with cast-in-place construction). Past studies in a large test chamber facility have shown that JGPPs can support very high axial and torsional loads owing to their improved skin and tip resistances subsequent to the side- and tip-grouting. However, this new pile has not yet been implemented in practice due to the lack of field verification of its constructability as well as load resistance. This paper presents the full-scale field construction of two JGPPs and the load test program performed to investigate the applicability of the new pile as a foundation for miscellaneous structures. As such structures are subjected to high torsion and lateral load during severe wind-loading (e.g., hurricanes), the test program included combined torsion and lateral loading as well as simple lateral loading. An actual pole – mast arm assembly was used in the coupled torsion and lateral load test to simulate the typical field-loading scenario. The load was applied using a crane and the pile’s rotations and translations were monitored using the novel instrumentation systems. The field tests showed that JGPPs possess high torsion and lateral resistances compared to identically sized drilled shafts, which is a common foundation type used for such structures. The two methods available for predicting axial resistance of the new pile are found to be suitable for the estimation of torsional resistance as well. It was also found that the concurrent application of torsion significantly reduces lateral resistance of the new pile foundation as observed for drilled shafts. In general, the study reveals that the JGPPs are well-suited foundations for miscellaneous structures.
Interview with Paul De Bra
Authors: Atzenbeck Claus
Published: March 2017

Prof. dr. Paul De Bra is Full Professor in the Department of Computer Science at the Eindhoven University of Technology (TU/e). He holds a doctorate in mathematics and computer science from the University of Antwerp, Belgium (1987), with a thesis on Horizontal Decomposition in the Relational Database Model. During 1988 and 1989 he was a post-doctoral researcher at AT&T Bell Laboratories in Murray Hill, New Jersey, studying principles and technology for WYSIYWYG interfaces for document processing. Since December 1989 he has been working at the TU/e, first as an associate professor, and since August 1996 as a full professor and chair of the Information Systems group. Since he started working at the TU/e the research has shifted to the area of hypertext and hypermedia, with research in adaptive Web-based systems. He initiated and led the AHAM (reference model), AHA! and GRAPPLE projects on adaptive Technology-Enhanced Learning, the NWO CHIP project on adaptation and personalization in Cultural Heritage, and numerous other activities to stimulate research and development of adaptive hypermedia technology and applications. He is scientific director of the Dutch Research School for Information and Knowledge Systems and is president of User Modeling Inc. (the non-profit organization for User Modeling and Adaptive Systems).

In "real" life Paul De Bra plays, repairs, composes and arranges for the accordion (and takes pictures at conferences too). "Paul De Bra" and "accordion" currently yields 76 hits on YouTube whereas "Paul De Bra" and "hypertext" yields 0. (On Google the hypertext query is more successful.)
How healthy are ACM SIGWEB sponsored conferences?
Authors: Agarwal Swati , Mittal Nitish , Sureka Ashish
Published: March 2017

ACM SIGWEB sponsors and supports several conferences covering a wide range of topics. CIKM, HT, WEBSCI and WSDM are four of the many sponsored conferences by ACM SIGWEB. CIKM, HT, WEBSCI and WSDM are reputed conferences, being held for several years and has a large community of contributing authors and PC members. In this article, we present a study on the health of these four conferences based on several factors and metrics such as stability, openness, inbreeding, representativeness, sustainability, prestige and workload. Studying the health of a conferences provides a reflection and historical overview in-terms of its performance which can be used by the conference community to bring improvements and ensure that the conference is meeting its desired objectives. We conduct statistical analysis and information visualization on the conference data downloaded from DBLP, ACM Digital Library web-pages and conference websites. Our analysis reveals that overall all the four conferences are showing good health indicators. We do observe variances in metrics values across conferences and within conferences across years.
What is an information source?
Authors: Söderlund C. , Lundin J.
Published: March 2017

This article examines information source selection behavior among maintenance technicians and how this behavior might influence the design of technical information. For this entry, "maintenance technicians" are individuals who maintain machine equipment (e.g., generators or bearings) in industrial enterprises, and this process includes the troubleshooting of problems and the repairing of machine equipment. In this entry, the authors use a review of the literature on information source selection behavior to discuss core concepts within the field of source selection behavior. Three of the main concepts examined are "information," "information source," and "source preference criteria." These core concepts function as a frame of reference for discussing how maintenance technicians might select information sources to perform maintenance activities. The authors also use these concepts to review why certain sources are selected for use over others. The results tentatively suggest maintenance technicians prefer information sources that can be adapted to specific workplace contexts.
Dental Abnormalities in Pituitary Dwarfism: A Case Report and Review of the Literature
Authors: Ferrante Franco , Blasi Sergio , Crippa Rolando , Angiero Francesca
Published: March 2017

Hypopituitarism is a disorder caused by a reduced level of trophic hormones that may be consequent on different destructive processes. The clinical manifestations depend on the type of hormone involved. A deficiency of growth hormone (GH) in children causes the lack of growth known as pituitary dwarfism. The case is reported of a patient with pituitary dwarfism, multiple dental anomalies, functional prosthetic problems, and a revision of the literature. She was subjected to prosthetic rehabilitation without surgical intervention, using zirconium substructures, thus eliminating the potential complications that may require trauma surgery. The therapeutic approach adopted led to excellent results and restored an aesthetic smile.
Atypical Femoral Shaft Fractures in Female Bisphosphonate Users Were Associated with an Increased Anterolateral Femoral Bow and a Thicker Lateral Cortex: A Case-Control Study
Authors: Jang Seung Pil , Yeo Ingwon , So Sang-Yeon , Kim Keunbyuel , Moon Young-Wan , Park Youn-Soo , Lim Seung-Jae
Published: March 2017

The purpose of our study was to investigate the radiographic characteristics of atypical femoral shaft fractures (AFSFs) in females with a particular focus on femoral bow and cortical thickness. We performed a fracture location-, age-, gender-, and ethnicity-matched case-control study. Forty-two AFSFs in 29 patients and 22 typical osteoporotic femoral shaft fractures in 22 patients were enrolled in AFSF group and control group, respectively. With comparing demographics between two groups, radiographically measured femoral bow and cortical thicknesses of AFSF group were compared with control group. All AFSF patients were females with a mean age of 74.4 years (range, 58–85 years). All had a history of bisphosphonate (BP) use with a mean duration of 7.3 years (range 1–17 years). Femoral bow of AFSF group was significantly higher than control group on both anteroposterior (AP) and lateral radiographs after age correction. Mean femoral bow on an AP radiograph was 12.39°±5.38° in AFSF group and 3.97±3.62° in control group (P<0.0001). Mean femoral bow on the lateral radiograph was 15.71°±5.62° in AFSF group and 10.72°±4.61° in control group (after age correction P=0.003). And cortical thicknesses of AFSF group demonstrated marked disparity between tensile and compressive side of bowed femurs in this study. An adjusted lateral cortical thickness was 10.5±1.4 mm in AFSF group and 8.1±1.3 mm in control group (after age correction P<0.0001) while medial cortical thickness of AFSF group was not statistically different from control group. Correlation analysis showed that the lateral femoral bow on the AP radiograph was solely related to lateral CTI (R=0.378, P=0.002). AFSFs in female BP users were associated with an increased anterolateral femoral bow and a thicker lateral cortex of femurs.
A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?
Authors: Papakonstantinou Vasiliki D. , Lagopati Nefeli , Tsilibary Effie C. , Demopoulos Constantinos A. , Philippopoulos Athanassios I.
Published: March 2017

In this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF) inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones and specific and nonspecific) as inhibitors of PAF are reported. Emphasis is given on recent results about a new class of the so-called metal-based inhibitors of PAF. A small library of 30 metal complexes has been thus created; their anti-inflammatory activity has been further evaluated owing to their inhibitory effect against PAF in washed rabbit platelets (WRPs). In addition, emphasis has also been placed on the identification of preliminarystructure-activityrelationships for the different classes of metal-based inhibitors.
Solutions for a Class of Nonperiodic Superquadratic Hamiltonian Elliptic Systems Involving Gradient Terms
Authors: Duan Shengzhong , Wu Xian
Published: March 2017

In the present paper, we consider the following Hamiltonian elliptic system HES: -Δu+bx·∇u+Vxu=Hvx,u,v,  x∈RN, -Δv-bx·∇v+Vxv=Hux,u,v,  x∈RN. A new existence result of nontrivial solutions is obtained for the system HES via variational methods for strongly indefinite problems, which generalizes some known results in the literatures.
B-Cell Lymphoma Patient-Derived Xenograft Models Enable Drug Discovery and Are a Platform for Personalized Therapy
Authors: Zhang Leo , Nomie Krystle , Zhang Hui , Bell Taylor , Pham Lan , Kadri Sabah , Segal Jeremy , Li Shaoying , Zhou Shouhao , Santos David , Richard Shawana , Sharma Shruti , Chen Wendy , Oriabure Onyekachukwu , Liu Yang , Huang Shengjian , Guo Hui , Chen Zhihong , Tao Wenjing , Li Carrie , Wang Jack , Fang Bingliang , Wang Jacqueline , Li Lei , Badillo Maria , Ahmed Makhdum , Thirumurthi Selvi , Huang Steven Y. , Shao Yiping , Lam Laura , Yi Qing , Wang Y. Lynn , Wang Michael
Published: March 2017

Purpose: Patients with B-cell lymphomas often relapse after frontline therapy, and novel therapies are urgently needed to provide long-term remission. We established B-cell lymphoma patient-derived xenograft (PDX) models to assess their ability to mimic tumor biology and to identify B-cell lymphoma patient treatment options.

Experimental Design: We established the PDX models from 16 patients with diffuse large B-cell lymphoma, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, or Burkitt lymphoma by inoculating the patient tumor cells into a human bone chip implanted into mice. We subjected the PDX models to histopathologic and phenotypical examination, sequencing, and drug efficacy analysis. Primary and acquired resistance to ibrutinib, an oral covalent inhibitor of Bruton tyrosine kinase, were investigated to elucidate the mechanisms underlying ibrutinib resistance and to identify drug treatments to overcome resistance.

Results: The PDXs maintained the same biological, histopathologic, and immunophenotypical features, retained similar genetic mutations, and produced comparable drug responses with the original patient tumors. In the acquired ibrutinib-resistant PDXs, PLC-γ2, p65, and Src were downregulated; however, a PI3K signaling pathway member was upregulated. Inactivation of the PI3K pathway with the inhibitor idelalisib in combination with ibrutinib significantly inhibited the growth of the ibrutinib-resistant tumors. Furthermore, we used a PDX model derived from a clinically ibrutinib-relapsed patient to evaluate various therapeutic choices, ultimately eliminating the tumor cells in the patient's peripheral blood.

Conclusions: Our results demonstrate that the B-cell lymphoma PDX model is an effective system to predict and personalize therapies and address therapeutic resistance in B-cell lymphoma patients. Clin Cancer Res; 23(15); 4212–23. ©2017 AACR.
Central Macular Thickness Monitoring after a Taxane-Based Therapy in Visually Asymptomatic Patients
Authors: Chelala Elias , Arej Nicolas , Antoun Joelle , Kourie Hampig Raphael , Zaarour Karen , Haddad Fady Ghassan , Farhat Fadi , El Karak Fadi , Kattan Joseph
Published: March 2017

Background: Taxanes are drugs used in various chemotherapeutical protocols to treat solid tumors. They have multiple systemic adverse effects, such as bone marrow suppression, alopecia, nausea, and vomiting, and may rarely cause ocular symptoms. In the past decade, a few reported cases have shown the occurrence of a cystoid macular edema with significant visual loss after the use of a taxane-based chemotherapy. The aim of this study was to compare the central macular thickness (CMT) before and after the initiation of a taxane-based therapy in visually asymptomatic patients and to elucidate the possible impact of these drugs on the vision of cancer patients. Methods: Patients with a confirmed diagnosis of a solid tumor were screened for any ophthalmic disease before inclusion and had a baseline macular spectral domain optical coherence tomography (OCT; RTVue-100; Optovue Inc., Fremont, CA, USA) before the initiation of a taxane-based chemotherapy according to different protocols, such as 4EC-4T, 3FEC/3T, or 4TC. OCT was repeated after 4 cycles (or 3 months) of treatment, and CMT was compared to baseline. Patients presenting diabetic retinopathy, age-related macular degeneration or any condition that causes macular edema confirmed by ophthalmic examination were excluded. Results: Fifty eyes of 25 patients were included; 92% of the subjects were female with a mean age of 48.52 years, 88% were diagnosed with breast cancer, 8% with esophageal cancer, and 4% with ovarian cancer. Docetaxel was the taxane administered to 92% of the patients. The received dose of docetaxel ranged between 110 and 160 mg. The other patients had paclitaxel in their protocols. No significant macular edema or drop in visual acuity were noted in any patient. Nevertheless, the mean CMT was found to be increased, particularly in the parafoveal and perifoveal areas (mean difference of +2.22 μm; p = 0.001). Conclusion: Taxane-based chemotherapy regimens seem to increase macular thickness, with a relative sparing of the fovea, in patients without significant macular edema. Further research is required to better explain the pathophysiology and possible impact of this phenomenon.
Blood Pressure Variability in Obstructive Sleep Apnoea: Data from 4 Randomised Controlled CPAP Withdrawal Trials
Authors: Lettau Franziska , Schwarz Esther I. , Stradling John R. , Kohler Malcolm
Published: March 2017

Background: Increased daytime blood pressure variability (BPV) is associated with cardiovascular risk. Preliminary data suggest that obstructive sleep apnoea (OSA) might contribute to increased daytime BPV. Objective: The aim of this study was to evaluate the effect of continuous positive airway pressure (CPAP) therapy withdrawal on daytime BPV. Methods: A total of 183 patients previously diagnosed with OSA and treated with CPAP were randomised to either continue or withdraw from CPAP within 4 trials. Office morning BP was measured in triplicate at baseline and at follow-up (day 14). In addition, the participants performed BP measurements at home on a daily basis (days 1-13). The main outcome of interest was the treatment effect on within-visit BPV expressed as the standard deviation (SD) of the triplicate measurements. Additional outcomes included morning home BPV and day-to-day home BPV. Results: Within-visit variability in systolic BP significantly increased in response to recurrence of OSA in the CPAP withdrawal group (difference between groups in SD of systolic BPV, +1.14 mm Hg, 95% CI +0.20/+2.09, p = 0.02). There was no statistically significant effect on within-visit variability in diastolic BP (p = 0.38) or heart rate (p = 0.07). Neither morning home BP variability (systolic BPV, p = 0.81; diastolic BPV, p = 0.46) nor day-to-day variability in home BP measurements (systolic BPV, p = 0.61; diastolic BPV, p = 0.58) differed significantly between the groups. Conclusion: CPAP withdrawal results in a minor increase in within-visit variability in office systolic BP, but it has no effect on home BPV or day-to-day BPV. Although the treatment effect may be blunted by antihypertensives, it is unlikely that OSA contributes to cardiovascular risk via elevated daytime BPV.
Genome-Wide Analysis of DNA Methylation and Acute Coronary Syndrome
Authors: Li Jun , Zhu Xiaoyan , Yu Kuai , Jiang Haijing , Zhang Yizhi , Deng Siyun , Cheng Longxian , Liu Xuezhen , Zhong Jia , Zhang Xiaomin , He Meian , Chen Weihong , Yuan Jing , Gao Ming , Bai Yansen , Han Xu , Liu Bing , Luo Xiaoting , Mei Wenhua , He Xiaosheng , Sun Shunchang , Zhang Liyun , Zeng Hesong , Sun Huizhen , Liu Chuanyao , Guo Yanjun , Zhang Bing , Zhang Zhihong , Huang Jinyan , Pan An , Yuan Yu , Angileri Francesca , Ming Bingxia , Zheng Fang , Zeng Qiutang , Mao Xiaobo , Peng Yudong , Mao Yi , He Ping , Wang Qing K. , Qi Lu , Hu Frank B. , Liang Liming , Wu Tangchun
Published: March 2017

Rationale:

Acute coronary syndrome (ACS) is a leading cause of death worldwide. Immune functions play a vital role in ACS development; however, whether epigenetic modulation contributes to the regulation of blood immune cells in this disease has not been investigated.

Objective:

We conducted an epigenome-wide analysis with circulating immune cells to identify differentially methylated genes in ACS.

Methods and Results:

We examined genome-wide methylation of whole blood in 102 ACS patients and 101 controls using HumanMethylation450 array, and externally replicated significant discoveries in 100 patients and 102 controls. For the replicated loci, we further analyzed their association with ACS in 6 purified leukocyte subsets, their correlation with the expressions of annotated genes, and their association with cardiovascular traits/risk factors. We found novel and reproducible association of ACS with blood methylation at 47 cytosine-phosphoguanine sites (discovery: false discovery rate <0.005; replication: Bonferroni corrected
P
<0.05). The association of methylation levels at these cytosine-phosphoguanine sites with ACS was further validated in at least 1 of the 6 leukocyte subsets, with predominant contributions from CD8
+
T cells, CD4
+
T cells, and B cells. Blood methylation of 26 replicated cytosine-phosphoguanine sites showed significant correlation with expressions of annotated genes (including
IL6R
,
FASLG
, and
CCL18
;
P
<5.9×10
−4
), and differential gene expression in case versus controls corroborated the observed differential methylation. The replicated loci suggested a role in ACS-relevant functions including chemotaxis, coronary thrombosis, and T-cell–mediated cytotoxicity. Functional analysis using the top ACS-associated methylation loci in purified T and B cells revealed vital pathways related to atherogenic signaling and adaptive immune response. Furthermore, we observed a significant enrichment of the replicated cytosine-phosphoguanine sites associated with smoking and low-density lipoprotein cholesterol (
P
enrichment
≤1×10
−5
).

Conclusions:

Our study identified novel blood methylation alterations associated with ACS and provided potential clinical biomarkers and therapeutic targets. Our results may suggest that immune signaling and cellular functions might be regulated at an epigenetic level in ACS.
A Comprehensive Analysis of Bilingual Lexicon Induction
Authors: Irvine Ann , Callison-Burch Chris
Published: March 2017

Bilingual lexicon induction is the task of inducing word translations from monolingual corpora in two languages. In this article we present the most comprehensive analysis of bilingual lexicon induction to date. We present experiments on a wide range of languages and data sizes. We examine translation into English from 25 foreign languages: Albanian, Azeri, Bengali, Bosnian, Bulgarian, Cebuano, Gujarati, Hindi, Hungarian, Indonesian, Latvian, Nepali, Romanian, Serbian, Slovak, Somali, Spanish, Swedish, Tamil, Telugu, Turkish, Ukrainian, Uzbek, Vietnamese, and Welsh. We analyze the behavior of bilingual lexicon induction on low-frequency words, rather than testing solely on high-frequency words, as previous research has done. Low-frequency words are more relevant to statistical machine translation, where systems typically lack translations of rare words that fall outside of their training data. We systematically explore a wide range of features and phenomena that affect the quality of the translations discovered by bilingual lexicon induction. We provide illustrative examples of the highest ranking translations for orthogonal signals of translation equivalence like contextual similarity and temporal similarity. We analyze the effects of frequency and burstiness, and the sizes of the seed bilingual dictionaries and the monolingual training corpora. Additionally, we introduce a novel discriminative approach to bilingual lexicon induction. Our discriminative model is capable of combining a wide variety of features that individually provide only weak indications of translation equivalence. When feature weights are discriminatively set, these signals produce dramatically higher translation quality than previous approaches that combined signals in an unsupervised fashion (e.g., using minimum reciprocal rank). We also directly compare our model's performance against a sophisticated generative approach, the matching canonical correlation analysis (MCCA) algorithm used by Haghighi et al. ( 2008 ). Our algorithm achieves an accuracy of 42% versus MCCA's 15%.
The Bird and the Mountains: A Note on Psalm 11
Authors: Quine Cat
Published: March 2017

This paper demonstrates that the bird and the mountains phrase in Ps 11:1 compares well with a common metaphor relating to siege warfare and military conquest found in Neo-Assyrian royal inscriptions and considers the resulting implications.
A taxonomic revision of the genus Anthriscus (Apiaceae) in Turkey
Authors: TEKİN MEHMET , CİVELEK ŞEMSETTİN
Published: March 2017

A taxonomic revision of Anthriscus (Apiaceae, tribe Scandiceae) in Turkey was carried out. The genus Anthriscus is represented by four sections and eight taxa, including six species with three non-typical infraspecific taxa in that territory, grouped into four sections: i) A. sect. Anthriscus (A. caucalis var. caucalis and A. tenerrima var. tenerrima); ii) A. sect. Cerefolium (A. cerefolium var. trichocarpa); iii) A. sect. Caroides (A. kotschyi); and iv) A. sect. Cacosciadium (A. lamprocarpa subsp. lamprocarpa, A. lamprocarpa subsp. chelikii, A. sylvestris subsp. sylvestris and A. sylvestris subsp. nemorosa). A new taxon, A. lamprocarpa subsp. chelikii, was found and published as a preliminary result of the present revisionary study. Some new characters such as length of filament and petal, and the ratio of fruit length to its beak length are used in the identification key for the first time. New localities of some taxa were found and their distribution areas are expanded. According to all morphological findings on Turkish Anthriscus, a new description of the genus was carried out. The taxonomic treatments for all taxa include type, synonyms (when present), morphological descriptions, phenology, and distribution areas (worldwide and local), habitats, phytogeographic region, conservation assessment and specimens examined. A new identification key for the sections and all Turkish species of the genus Anthriscus is reported, and illustrations and distribution maps in Turkey are also given for eight taxa.
A new species of Priochilus Banks, 1944 (Hymenoptera, Pompilidae, Pompilinae) from Panama
Authors: WASBAUER MARIUS S. , CAMBRA ROBERTO A. , AÑINO YOSTIN J.
Published: March 2017

Priochilus chrysopygus Wasbauer, Cambra & Añino sp. nov. based on both sexes is described and illustrated. This new species is related to P. splendidulus (Fabricius). A short synopsis of biology in the genus Priochilus is given.
Two bathyal hydroids (Hydrozoa: Leptothecata) from the Southwest Indian Ocean
Authors: WATSON JEANETTE E.
Published: March 2017

Two species of hydroids were recovered from a mooring rope and experimentally deployed whale bone attached to an underwater transponder buoy at a depth of 732 m on the Coral Seamount on the Southwest Indian Ocean Ridge (41° 22.31’S, 54° 57’E) in the Southern Indian Ocean. The material was collected approximately 1,500 km south south-east of Madagascar during Voyage JC066 of the British Royal Research Ship R.R.S. James Cook on 20/11/2011. Hydroids were collected from the mooring rope and whale bone on board the ship after underwater retrieval by ROV.
Inside and out: a critical analysis of social capital
Authors: Cairns Joanne Marie
Published: March 2017

Divergent narratives from a former coal-mining ‘community’ in the North East of England are analysed using Bourdieu's conceptualisation of social capital. Thirty-three research participants (20 females; 13 males) took part in 15 semi-structured interviews and three focus groups over a six-month period (May and October 2011). The research findings showed that social capital can be simultaneously inclusive and exclusive for different demographics depending on age, gender, how long they have lived in the area and their (lack of) connection to the former coal-mining community. Social, spatial and temporal processes are important in making sense of these findings.
Os SIG como ferramenta de suporte nos cuidados de saúde primários: caso de estudo na distribuição de enfermeiros de família por área geográfica
Authors: Fonseca Luís Carlos Santos , Sousa Ana Maria Rodrigues Monteiro de
Published: March 2017

Com este trabalho procuramos mostrar o valor acrescentado dos Sistemas de Informação Geográfica (SIG) quando arquitetados e construídos de raiz numa perspetiva sistémica para um fim específico. Neste caso em concreto utilizamos a nossa questão de partida - definição de áreas geográficas homogéneas para a distribuição de enfermeiros de família para a Unidade de Saúde Familiar (USF) da Nova Via pertencente ao Agrupamento de Centros de Saúde de Espinho/Gaia na Área Metropolitana do Porto- para construir um suporte de gestão adaptado à realidade vivida numa Unidade de Saúde Familiar. https://doi.org/10.14195/1647-7723_24_11
Dziedzictwo zrytualizowanej przemocy na Sumbie Zachodniej
Authors: Jarmułowicz Małgorzata
Published: March 2017

Niniejszy artykuł analizuje przejawy dziedzictwa zrytualizowanej przemocy w rejonie Sumby Zachodniej w Indonezji na przykładzie jego dwóch tradycyjnych emblematów tradycyjnego noża parang oraz rytualnego turnieju wojny Pasola, które są charakterystyczne dla tej części wyspy. Autorka opisuje korzenie historyczne tego fenomenu, analizując jego różne funkcje kulturowe oraz przyczyn jego trwałej obecności we współczesnej przestrzeni społecznej Sumby Zachodniej.