bluuebunny/crossref_metadata_2025 huggingface dataset:
Autonomy within entanglements: Illegalised migrants, the EU border regime, and the political economy of Nouadhibou, Mauritania
Authors: Ould Moctar Hassan
Published: March 2022

This article contributes to debates about the autonomy of migration (AoM) by ethnographically detailing the EU border regime's external operations in Nouadhibou, Mauritania. In showing how the EU border regime is entangled within the political economy and social relations of the city, it offers three contributions to AoM discussion. Firstly, it nuances and reframes the interplay between illegalised migrants and the border regime by showing that it can take multiple forms, some less antagonistic than others. Secondly, it contextualises this interplay by situating it within the historical trajectory and social relations of the political economy in which it unfolds. Thirdly, it highlights the relevance of the Global South context of this analysis to AoM debate, much of which has been concerned with European contexts and Europe-bound movement.
Rural arts entrepreneurs’ placemaking – how ‘entrepreneurial placemaking’ explains rural creative hub evolution during COVID-19 lockdown
Authors: Hill Inge , Manning Louise , Frost Richard
Published: March 2022

This article critically evaluates the development and impact of a new online ‘dance practice’ service in a rural creative hub Remote. The research asks: ‘How does entrepreneurial placemaking contribute to the evolution of rural creative hubs during the COVID-19 pandemic?’ To answer this question, the article critically evaluates the business activities of one artisan entrepreneur, applying placemaking and resilience. Using a case study strategy, this research employs online qualitative research. Creative hub development is explained as a result of ‘entrepreneurial placemaking’, forming the main contribution of this article. This term subsumes multi-layered exchanges. ‘Entrepreneurial placemaking’ is conceptualised as continuous becoming, and illustrated by Remote’s adaption processes to lockdown phases. Remote is turned into a stage for digital placemaking during the COVID-19 lockdown via the ‘open dance practice’ service provided by a performance dance artist. Findings highlight that to enact entrepreneurial placemaking, creative professionals need to draw upon adaptive capacity, which includes the ability to develop exchange relationships and business-related digital skills. Peer-learning is a recommended solution for developing such digital skills across artist entrepreneurial communities. This article contributes to the ongoing conversation on the role of creative hubs for socio-economic development foregrounding the activities of hub users.
Drug-eluting balloon (DEB) versus plain old balloon angioplasty (POBA) in the treatment of failing dialysis access: A prospective randomized trial
Authors: Fransson Torbjörn , Gottsäter Anders , Abdulrasak Mohammad , Malina Martin , Resch Timothy
Published: March 2022

Objective

To compare the efficacy of angioplasty using drug-eluting balloons (DEB) compared with plain old balloon angioplasty (POBA) to reduce the rate of restenosis.

Methods

This prospective, single-centre, single-blinded, 1:1 randomized, clinical trial enrolled patients that had primary or restenotic lesions in native upper extremity arteriovenous (AV) fistulas or at the graft-venous anastomosis. Patients were randomized to angioplasty with a POBA or a DEB. The primary effectiveness endpoints were freedom from target lesion revascularization (TLR) and functional status of access circuit at 12 months.

Results

A total of 42 (28 male, 14 female; age range, 42–83 years) patients were enrolled. Patients were followed for 12 months. No significant differences were detected between the POBA and DEB groups regarding total number of TLR procedures (31 versus 36, respectively), freedom from TLR (3 versus 4, respectively) and functional status of the access circuit at 12 months (14 of 20 patients [70%] versus 17 of 22 patients [77%], respectively).

Conclusion

This clinical trial did not demonstrate any significant differences between DEB angioplasty and standard balloon angioplasty when treating dysfunctional haemodialysis access.
Invisible children: The out-of-home care and education of babies and toddlers
Authors: Jackson Sonia , Figueira-Bates Cora , Hollingworth Katie
Published: March 2022

Many thousands of very young children pass through the UK care system every year. Understandably, social workers are reluctant to separate children from their parents, and legal protections designed to prevent the separation from becoming permanent lead to constant delay in making longer-term plans. The aim is that the children should either be returned to their birth families or placed for adoption, but this is not achieved in up to 50% of cases. Consequently, many infants and toddlers remain in foster care, intended to be temporary, for long periods. Yet we know little about their lives in care or who looks after them.

Research on foster care and on early childhood education and care (ECEC) has developed on separate and unrelated lines, resulting in an extreme shortage of empirical evidence about the care and education of fostered children under school age. Lack of attention to this critical period of life fails to take account of advances in research both on early brain development and on the lasting effects of adverse childhood experiences. Meanwhile, young children continue to be moved between short-term foster placements for administrative reasons, ignoring the undisputed importance of stable early attachments. The potential of foster care as a learning and therapeutic resource in the early years has also been largely overlooked. Better mental health and educational attainment for children in out-of-home care require a much stronger policy focus on their earliest experiences and developmental progress. This article argues that there is an urgent need for research-based information to guide policy and practice.
Psychological implications of the ‘Back to the Origins' journey for intercountry adoptees
Authors: Santona Alessandra , Tognasso Giacomo , Carella Cristiana , Gorla Laura , Raymondi Marina , Chistolini Marco
Published: March 2022

One way in which intercountry adoptees can elaborate on their past history is through travelling to their country of birth. This article explores the memories and experiences recalled by a group of adoptees who visited their homeland after being adopted as children by Italian families. The sample comprised 34 participants aged between 12 and 40 years who visited their birth country between 2000 and 2013. In 2017–2018, they were asked to complete a questionnaire designed to obtain retrospective recall of their experiences and feelings on return to Italy, and how their ethnic identity and psychological well-being had been affected by the trip. The results revealed that the adoptees’ emotional experiences during the return visit significantly affected their feelings towards adoption itself and that it changed their sense of belonging both to Italy and the country where they were born. Most also perceived their return travel as a momentous occasion which increased their overall knowledge about their birth country and its culture. The results are significant for providing new information about how international adoptees incorporate their homeland culture into their lives.
Childlessness among adopted women: A study of the role of attachment through Bird’s Nest Drawings
Authors: Bouteyre Evelyne , Halidi Onsua , Despax Johanna
Published: March 2022

Adopted adults are presented in the literature as having a more insecure attachment than the general population. They are also less likely to want to have children of their own, which is significant in that studies have shown that attachment is an important determinant of the desire for parenthood. The aim of the present study was to link these two findings and seek a better understanding of the role of attachment in adoptees’ choice of childlessness. Semi-structured interviews were conducted with seven nulliparous adopted women who did not wish to have children; during these interviews they also undertook the Bird’s Nest Drawing (BND) test. This allows access to participants’ parental representations in addition to measuring their attachment. Analysis of the drawings and associated stories suggested that insecure attachment (especially avoidant) is particularly decisive in the choice of childlessness. Their interview responses stressed adequate or inadequate mothering, self-sufficiency and threat to the family, which further indicated why the women chose not to have children. The theoretical and clinical implications of the findings are discussed, particularly the value of the Bird’s Nest Drawing test for adults who have experienced early discontinuities in their lives.
En Réponse Au Projet De Loi 2 : Associations Entre Les Démarches Légales D’affirmation Du Genre et Deux Indicateurs De Bien-être Chez Des Personnes Trans et Non-Binaires Du Québec
Authors: Cotton Julie Christine , Martin-Storey Alexa , Le Corff Yann , Beauchesne Lévesque Séré Gabriel , Pullen Sansfaçon Annie
Published: March 2022

Mots-clés bien-être, détresse psychologique, satisfaction devie, transition légale, identité de genre, trans, non-binaire
A Typology of Local and State Government Responses to Racism: A Case of Anti-Asian Hate in the COVID-19 Pandemic
Authors: Lee C. Aujean , Arroyo John C.
Published: March 2022

We examine local and state government responses to anti-Asian hate during the initial months of the coronavirus (COVID-19) pandemic in the United States. Formal state and municipal government statements and websites were examined for fifty states and 104 of the largest municipalities using critical discourse analysis and racial formation theory to understand how government agencies racialized Asian Americans and reacted to their responsibility to address racism. We develop a typology of racist, race-neutral, and anti-racism to categorize the responses. Government statements are important for planners because they affect resident safety and willingness to report hate crimes.
The future of artificial intelligence in medicine: Medical-legal considerations for health leaders
Authors: Jassar Sunam , Adams Scott J. , Zarzeczny Amy , Burbridge Brent E.
Published: March 2022

Artificial Intelligence (AI) is becoming increasingly common in healthcare and has potential to improve the efficiency and quality of healthcare services. As the utility of AI expands, medical-legal questions arise regarding the possible legal implications of incorporating AI into clinical practice. Particularly, the unique black box nature of AI brings distinct challenges. There is limited guidance addressing liability when AI is used in clinical practice, and traditional legal principles present limitations when applied to novel uses of AI. Comprehensive solutions to address the challenges of AI have not been well established in North America. As AI continues to evolve in healthcare, appropriate guidance from professional regulatory bodies may help the medical field realize AI’s utility and encourage its safe use. As the options for AI in medicine evolve, physicians and health leaders would be prudent to consider the evolving medical-legal context regarding use of AI in clinical practices and facilities.
Vericiguat: The First Soluble Guanylate Cyclase Stimulator for Reduction of Cardiovascular Death and Heart Failure Hospitalization in Patients With Heart Failure Reduced Ejection Fraction
Authors: Tran Bao-Anh , Serag-Bolos Erini S. , Fernandez Joel , Miranda Aimon C.
Published: March 2022

Objective: This study aims to review the pharmacology, efficacy, and safety of the soluble guanylate cyclase stimulator, vericiguat, in patients with symptomatic congestive heart failure with ejection fraction less than 45% for the reduction of cardiovascular deaths. Also, to evaluate heart failure–related hospitalization in patients following a hospital discharge secondary to heart failure or those that require outpatient intravenous diuretics. Data source: MEDLINE/Pubmed and National Institutes of Health Clinical Trial Registry were searched between January 1989 to February 2021 using the following terms: vericiguat, soluble guanylate cyclase stimulator, heart failure, (was also known as) BAY 1021189. Study Selection and Data Extraction: The following study designs were included in the analysis: phase I, II, and III clinical trials; systematic reviews; and meta-analyses. Articles were included if they were published in English and evaluated vericiguat pharmacology, pharmacokinetics, efficacy, and safety. Data Synthesis: The Food and Drug Administration approved vericiguat for the reduction of cardiovascular death and hospitalization after having a related hospitalization or the need for outpatient intravenous diuretics, in those with symptomatic chronic heart failure and ejection fraction less than 45%. In the VICTORIA trial, vericiguat demonstrated a 10% reduction in risk of death from cardiovascular causes or first hospitalization for heart failure compared with placebo. Vericiguat was well tolerated overall with hypotension, syncope, and anemia noted as the most common side effects, similar to the other agent in its class. Conclusion: Vericiguat may be appropriate as add-on therapy for patients already on guideline-directed medical therapy with recent decompensated HFrEF to reduce hospitalization.
The Importance of Random Slopes in Mixed Models for Bayesian Hypothesis Testing
Authors: Oberauer Klaus
Published: March 2022

Mixed models are gaining popularity in psychology. For frequentist mixed models, previous research showed that excluding random slopes—differences between individuals in the direction and size of an effect—from a model when they are in the data can lead to a substantial increase in false-positive conclusions in null-hypothesis tests. Here, I demonstrated through five simulations that the same is true for Bayesian hypothesis testing with mixed models, which often yield Bayes factors reflecting very strong evidence for a mean effect on the population level even if there was no such effect. Including random slopes in the model largely eliminates the risk of strong false positives but reduces the chance of obtaining strong evidence for true effects. I recommend starting analysis by testing the support for random slopes in the data and removing them from the models only if there is clear evidence against them.
Digital mothering: Sharenting, family selfies and online affective-discursive practices
Authors: Lazard Lisa
Published: March 2022

Posting about one’s children and family has become a routine practice for mothers on social media. The task of presenting oneself as a “good” mother is subject to the trouble of competing requirements around motherhood (e.g., neoliberal intensive mothering, feminine relationality) as well as family ideals which are unrealistic for many. These troubles are further complicated by sharenting discourses in which parental posting is seen as digital narcissism. This study examines mothers’ identity work in their talk about posting family photos to social media. Twenty mothers aged between 24 and 50 were interviewed using their family photo posts as interview stimulus. Using a feminist poststructuralist framework, the data were discursively analysed, paying attention to how identity trouble was produced and repaired in three constructions of mothers’ photo sharing which included: emotionally connected mothers; digitally relational mothers; and proud mothers. In these constructions, family photo posts were constituted as a selective process which performed relational work to rhetorically manage the networked audience by deflecting conflict. This included the digital repair of offline troubled identities to present oneself as “good” whilst avoiding class-based othering. How these findings offer a challenge to predominant problematisations of digital mothers is discussed.
Loyalty, Liberty, and the Law: Analysing the Juxtaposition of Nation and Citizen in the Indian Sedition Law
Authors: Pattnaik Ayesha
Published: March 2022

This article examines the Indian sedition law laid out in Section 124(A) of the Indian Penal Code (IPC) which criminalises expression of disaffection towards the government. It analyses the functions of the sedition law in colonial and constitutional India. Rather than taking a legal approach to examine whether the sedition law is inimical to democracy, this socio-legal analysis studies the media and political discourse around sedition cases to evoke an underlying pattern of the use of the law across time and political regimes. It reveals how the law has been used in contemporary India to weave a narrative of the nation-state and national interests, often pitted against human rights and individual liberties. It goes on to argue that in post-colonial India, the law has simultaneously been critical in building a binding national identity while also enabling nationalism to be used as a political instrument that can subversively monitor and discipline citizens.
Developing, Nurturing, and Sustaining an Adolescent and Young Adult-Centered Culture of Care
Authors: Lea Sarah , Taylor Rachel , Gibson Faith
Published: March 2022

Adolescents and young adults have unique needs which differ from those of children or adults. In the United Kingdom, we have dedicated services, which are diverse in how they are managed and delivered. A multiple-case study was conducted in young people’s cancer services in four geographical regions of England. Data collection included: semi-structured interviews with healthcare professionals ( n = 41) and young people ( n = 29); and observation (total = 120 hours). Thematic analysis was used to synthesize and interpret five emerging themes describing the way a culture of adolescent and young adult-specific care developed. To develop a cultural attitude which embraced and promoted core values, leadership was needed, as well as high patient volume accessing a service. Time was essential, an adolescent and young adult-centered culture of care does not happen overnight, it needs time and dedicated staff to evolve, but once in place, services have a significant impact on the experience of care.
Incident cases of vision impairment and blindness among adult foreign-born and Swedish-born individuals: A national Swedish study
Authors: Wändell Per , Li Xinjun , Carlsson Axel C , Sundquist Jan , Sundquist Kristina
Published: March 2022

Purpose

To analyse risk of vision impairment (VI) and blindness in adult foreign-born individuals and Swedish-born individuals.

Methods

A nationwide study of individuals 18 years of age and older (N = 6,042,891; 2,902,918 men and 3,139,973 women) in Sweden. VI (in general) and blindness was defined as at least one registered diagnosis in the National Patient Register between January 1, 1998 and December 31, 2015. Cox regression analysis was used to estimate the relative risk (hazard ratios (HR) with 95% confidence intervals (CI)) of incident VI in foreign-born compared to Swedish-born individuals. The Cox regression models were stratified by sex and adjusted for age, co-morbidities, and for sociodemographic status.

Results

A total of 14,597 cases (6433 men and 8164 women) of VI were registered, with an age-standardized incidence per 100,000 person-years of 10.37 in men and 11.03 in women. VI (in general) was more common in immigrants, fully adjusted HRs (95% CI) were for immigrant men 1.38 (95% CI, 1.29–1.48) and women 1.24 (95% CI, 1.16–1.32), with significantly higher HRs among men and women from Eastern Europe, Africa, Latin America and Asia. Higher risks of blindness were also seen for immigrant men, HR 1.75 (95% CI 1.36–2.25), as well as for the other degrees of VI among immigrant men, HR 1.36 (95% CI 1.26–1.47), and immigrant women, HR 1.26 (95% CI 1.18–1.35).

Conclusions

We observed a generally higher risk of VI among foreign-born men and women, especially from some regions.
Metagenomics of infective canaliculitis: The Lacriome paper 3
Authors: Ali Mohammad Javed
Published: March 2022

Purpose

To study the metagenomics of the microbes isolated from the canaliculus of patients with infective canaliculitis.

Methods

A prospective study was performed on five consecutive canalicular samples obtained for the metagenomic analysis from the patients with infective canaliculitis who underwent non-incisional canalicular curettage at a tertiary care Dacryology service. The canalicular concretions were collected intraoperatively soon after a canalicular curettage and immediately transported on ice to the laboratory. Following DNA extraction and library preparation, a whole shotgun metagenome sequencing was performed on the Illumina™ platform. The downstream processing and bioinformatics of the samples were performed using multiple software packaged in SqueezeMeta™ pipeline or MG-RAST™ pipeline.

Results

The taxonomic hit distribution across the samples showed that bacteria were the most common isolates (mean—80.5%), followed by viruses (mean—0.74%), and archaea (0.01%). The five major phyla identified across the samples of infective canaliculitis were, Fusobacteria, Bacteroidetes, Proteobacteria, Actinobacteria, and Firmicutes. The prevalent organisms include Fusobacterium nucelatum, Fusobacterium periodonticum, Parvimonas micra, Prevotella oris, Selonomonas noxia, Pseudopropionobacterium propoinicum, Campylobacter showae, and Streptococcus anginosus, amongst few others. Actinomycetes israelii was noted in all the samples, though it was not the most abundant. The microbial gene mapping and protein prediction demonstrated proteins with known functions to range from 69.91% to 87.09% across the samples. The functional subsystem profiling demonstrated genes associated with carbohydrate, amino acid, and co-enzyme transport and metabolism, cell wall or cell membrane biogenesis, energy production and conversion, transcription, translation, and cellular communications.

Conclusion

This is the first whole metagenome sequencing of infective canaliculitis. Infected canaliculi harbor diverse microbial communities, including bacteria, viruses, and archaea. Functional analysis has provided newer insights into the ecosystem dynamics and strategies of microbial communities.
Rapid Improvement in Skin Pain Severity and Its Impact on Quality of Life in Adult Patients With Moderate-to-Severe Atopic Dermatitis From a Double-Blind, Placebo-Controlled Baricitinib Phase 3 Study
Authors: Rosmarin David , Fretzin Scott , Strowd Lindsay , Casillas Marta , DeLozier Amy M. , Dawson Zach , Chen Sherry , Lu Na , Thyssen Jacob P.
Published: March 2022

Background

Skin pain (discomfort/soreness) is a common symptom associated with atopic dermatitis (AD).

Objective

To evaluate rapid changes in skin pain severity with baricitinib, and its impact on patient quality of life (QoL) in adults with moderate-to-severe AD who were inadequate responders to topical therapy.

Methods

Adult patients with moderate-to-severe AD who were inadequate responders to topical therapies ( N = 440, BREEZE-AD5 [NCT03435081]) were randomized to once-daily placebo, baricitinib 1 mg, or baricitinib 2 mg for 16 weeks. Change in Skin Pain Numeric Rating Scale (NRS) scores were assessed for the randomized population. Skin Pain NRS and Dermatology Life Quality Index (DLQI) scores were assessed for Skin Pain Response groups and patients with Body Surface Area (BSA) 10% to 50%.

Results

Skin Pain NRS improvement was significant versus placebo by day 1 baricitinib 2 mg (least squares mean [LSM] difference −4.4%, P = .048) and by day 2 for baricitinib 1 mg (−6.7%, P = .011). As measured weekly, improvement was significant starting at Week 1 and remained significant through Week 16 for both doses. At Week 16, 70.9% of Skin Pain NRS responders vs 10.4% of nonresponders had a clinically meaningful improvement in DLQI ( P < .0001). At week 16, LSM DLQI change from baseline was −11.1 for all Skin Pain NRS responders versus −3.5 for nonresponders ( P < .0001). Patients with BSA 10% to 50% showed similar trends.

Conclusions

Patients with moderate-to-severe AD, treated with baricitinib, reported rapid improvements in skin pain severity by day 1 for baricitinib 2 mg and day 2 for baricitinib 1 mg and remained effective through 16 weeks of treatment, which positively impacted patient QoL.
Design ethnography: A view from an industrial think tank
Authors: Kirsch Stuart
Published: March 2022

Anthropologists increasingly turn to design research for inspiration. Yet work in design anthropology is frequently cut off from ethnographic research. To some extent this is intentional, given concerns that ethnographic methods have failed to keep pace with a rapidly changing world. But anthropologists should not have to choose between ethnography and design research. This article examines the author’s participation in an industrial think tank in which anthropologists and engineers collaborated to address the environmental impacts of mining. This included discussion of unrecognized sources of pollution at mining sites and rising penalties for environmental damage. The members of the think tank also developed designs for new technology intended to reduce the exposure of artisanal gold miners to mercury and its release into the atmosphere, facilitate the recycling of electronic waste in developing countries, and reduce the catastrophic risks posed by tailings dams. Our collaborations point to the value of combining ethnography and design research in new ways.
Longitudinal Tear of the Central Slip Causing Painful and Unusual Snapping of the Finger: A Case Report
Authors: Chan Peter Y. W. , Tan Virak
Published: March 2022

The most common cause for catching or snapping in the finger is stenosing tenosynovitis, that is, trigger finger. Although less common, snapping can also occur as a result of extensor mechanism injury. Among these injuries, sagittal band rupture is most common and leads to snapping at the metacarpophalangeal joint. Snapping at the proximal interphalangeal (PIP) joint is rare with only 4 reported cases; reported mechanisms of PIP joint snapping include retinacular ligament injury or tendon impingement. We present a unique case of painful finger snapping at the PIP joint as a result of longitudinal tear of the central slip, leading to sudden subluxation of one-half of the central slip and conjoint lateral band with flexion of the PIP joint.
Mobile robot 3D trajectory estimation on a multilevel surface with multimodal fusion of 2D camera features and a 3D light detection and ranging point cloud
Authors: Rosas-Cervantes Vinicio , Hoang Quoc-Dong , Woo Sooho , Lee Soon-Geul
Published: March 2022

Nowadays, multi-sensor fusion is a popular tool for feature recognition and object detection. Integrating various sensors allows us to obtain reliable information about the environment. This article proposes a 3D robot trajectory estimation based on a multimodal fusion of 2D features extracted from color images and 3D features from 3D point clouds. First, a set of images was collected using a monocular camera, and we trained a Faster Region Convolutional Neural Network. Using the Faster Region Convolutional Neural Network, the robot detects 2D features from camera input and 3D features using the point’s normal distribution on the 3D point cloud. Then, by matching 2D image features to a 3D point cloud, the robot estimates its position. To validate our results, we compared the trained neural network with similar convolutional neural networks. Then, we evaluated their response for the mobile robot trajectory estimation.
The effective coaching factors in operational managers of Persian gulf petrochemical company in motivation of human resources
Authors: Hajizadeh Hajat , Makvandi Foad , Amirnejad Ghanbar
Published: March 2022

Coaching encourages individuals to focus on their strengths instead of their weaknesses. The studies show that emphasizing the employees’ strengths can reduce turnover, increase productivity, and improve job satisfaction. This study investigated the effective coaching factors in operational managers of the Persian Gulf Petrochemical Company in motivation of human resources. The present study is practical and descriptive-correlational in terms of objective and data gathering, respectively. Structural Equation Modeling (SEM) was performed in SMART PLS to model the collected data. The statistical population included all the 340 operational managers of the Persian Gulf Petrochemical Company. 182 individuals were selected and evaluated from this statistical population. Questionnaires were used for data collection. The researcher-made questionnaire was extracted based on the model prepared in the previous stage using a grounded theory approach. The results showed that communication, organizational strategy and goals, legal requirements, motivation, organizational training, empowerment, teamwork, succession, organizational agility, job satisfaction, organizational structure, human resources management, organizational culture, participatory management, talent management, knowledge management, coaching, managers’ competencies, compensation system, job satisfaction, staff characteristics, organizational characteristics, and learning have significant impacts in motivation of human resources.
High Prevalence of Pain Sensitization in Knee Osteoarthritis: A Meta-Analysis with Meta-Regression
Authors: Previtali Davide , Capone Gianluigi , Marchettini Paolo , Candrian Christian , Zaffagnini Stefano , Filardo Giuseppe
Published: March 2022

Objective

The aim of this meta-analysis was to study the evidence on pain sensitization in knee osteoarthritis (OA), providing a quantitative synthesis of its prevalence and impact. Factors associated with pain sensitization were also investigated.

Methods

Meta-analysis; PubMed (MEDLINE), Cochrane Central Register (CENTRAL), and Web of Science were searched on February 2021. Level I to level IV studies evaluating the presence of pain sensitization in patients with symptomatic knee OA, documented through a validated method (questionnaires or quantitative sensory testing), were included. The primary outcome was the prevalence of pain sensitization. Factors influencing the prevalence were also evaluated, as well as differences in terms of pain thresholds between knee OA patients and healthy controls.

Results

Fifty-three articles including 7,117 patients were included. The meta-analysis of proportion documented a prevalence of pain sensitization of 20% (95% confidence interval [CI] = 16%-26%) with a significant heterogeneity of results ( I2 = 89%, P < 0.001). The diagnostic tool used was the main factor influencing the documented prevalence of pain sensitization ( P = 0.01). Knee OA patients presented higher pain sensitivity compared with healthy controls, both in terms of local pressure pain threshold (standardized mean difference [SMD] = −1.00, 95% CI = −1.67 to −0.32, P = 0.007) and distant pressure pain threshold (SMD = −0.54, 95% CI = −0.76 to −0.31, P < 0.001).

Conclusions

Knee OA pain presents features that are consistent with a significant degree of pain sensitization. There is a high heterogeneity in the reported results, mainly based on the diagnostic tool used. The identification of the best methods to detect pain sensitization is warranted to correctly evaluate and manage symptoms of patients affected by knee OA.

Registration:

PROSPERO CRD42019123347.
Integrating the experience: Principles for digital transformation across the patient journey
Authors: de Mooij Marnie , Foss Olivia , Brost Brian
Published: March 2022

As medical science advances and the population ages, the prevalence of chronic conditions has also grown. The traditional model of care, with its focus on acute and episodic issues within the office visit, is not designed to meaningfully address long-term patient needs. With COVID-19 has come unprecedented digital adoption, bringing health care delivery to a critical juncture. While digital tools and technologies present vast opportunities for democratizing and decentralizing care experiences, their piecemeal application to the existing “sick care” model and its information technology infrastructure will not only limit their value, but will inevitably add cost, inefficiency, and burden to care teams. In order to build upon this momentum and reap the full benefits of practice digitization, care model transformation must occur. This entails holistically reexamining how every component of the health care experience, from the digital tools to visit interactions, synchronizes to address the full continuum of patient needs throughout the journey. By doing this, care shifts away from one-size-fits-all, fragmented strings of visits, toward seamless experiences that adapt to patients’ needs in real-time while integrating within their daily lives. Rather than acting as a substitute for care, technology instead is vital to promoting and amplifying the impact of all those involved. To achieve this, this paper outlines 10 principles for restructuring care to incorporate digital health capabilities. Each describes how all care model components work as a system that aligns with patient needs. By doing this, technology is now an integral in supporting relationships across the full continuum of care.
How do the Expectations of Faculty Members Influence the Quality and Acquisition of Knowledge in the Academic Environment? The Case of Slovenia
Authors: Kovač Šebart Mojca , Kovač Miha , Vidmar Tadej , Mažgon Jasna
Published: March 2022

The text questions the assumption of the Bologna reform that student-centered learning will improve the quality of university study. Research conducted on a sample of 429 students from various study programs at two faculties of the University of Ljubljana, whom we asked about their reading and study habits, showed that relying on the subjective motivation of students alone is not enough to ensure that they read compulsory reading material and thus acquire the knowledge that only this type of study can bring. We therefore emphasize in the conclusion that calling for motivation that is tied to interest may actually have the effect of putting students off reading material that is not related to their direct interest or does not show directly applicable value. The results of the study also show that students are clearly attentive to the requirements and expectations of individual faculty member and therefore adapt their method of study (and the amount they study) in such a way as to satisfy these (frequently low) expectations.
The IBTIS score, a new predictive score for arthroscopic biceps tenotomy
Authors: Bozon Olivier , Chiche Léo , Salabi Vincent , Lazerges Cyril , Chammas Michel , Coulet Bertrand
Published: March 2022

Objectives:

Shoulder pain related to long head of biceps tendinopathy is common. Surgical treatment by arthroscopic tenotomy has proven to be effective. The objective was to evaluate the preoperative clinical and radiological prognostic factors of arthroscopic tenotomy of the long head of biceps, and to establish a predictive score of good response to treatment.

Methods:

We conducted a retrospective single-center study including 64 patients who underwent surgery between January 2018 and March 2020 by arthroscopic LHB tenotomy, whether or not associated with tenodesis. We identified 2 groups of patients based on a clinical evaluation 3 months postoperatively, which included subjective assessment by the Single Shoulder Value (SSV), Constant, C-Test, and pain scores: a good responder group and a poor responder group. Prognostic factors for good response were then identified in the 2 groups based on questioning, clinical examination and preoperative imaging. Based on these factors, a predictive score for a good response was established.

Results:

All evaluation criteria showed postoperative improvement: Mean SSV (72.2 vs 50.7; p 65 years (p = 0.01), cuff tear on preoperative imaging (p = 0.01), the Cross Arm Test (p = 0.02), night-time pain (p = 0.08), Yergason’s test (p = 0.16), the Speed Test (p = 0.22). Manual labor appeared to be a factor in an unfavorable outcome (p = 0.07). These factors were incorporated into the 10-point IBTIS score. A score above 5 was associated with a favorable outcome in more than 80% of the patients (p <0.001).

Conclusion:

The IBTIS (Isolated Biceps Tenotomy Index Score) is a preoperative clinical and radiological score with 7 items for surgical treatment by arthroscopic tenotomy of the long head of biceps. Further studies are required to validate the prognostic accuracy.
Is Insurance Status Associated With Likelihood of Operative ACL Injury Treatment Compared With Nonoperative Treatment?
Authors: Otero Katie , Congiusta Dominick , Galdi Balazs
Published: March 2022

Background:

While many factors inform the choice of operative versus nonoperative treatment of injuries to the anterior cruciate ligament (ACL) of the knee, socioeconomic status influences this decision, as has been reported with other procedures.

Purpose:

To identify any associations between insurance status and likelihood of operative treatment of ACL injuries.

Study Design:

Cross-sectional study; Level of evidence, 3.

Methods:

The Nationwide Inpatient Sample database was queried using International Classification of Diseases, 9th Revision codes for ACL injuries and reconstruction from 2001 to 2013. Chi-square analysis was performed to determine significant predictors of operative intervention. Binary logistic regression was used to account for demographic and significant predictor variables. Results were recorded as odds ratios (ORs) and 95% CIs. Significance was defined as P < .05.

Results:

A total of 32,541 patients with ACL injuries were included in the final analysis. Overall incidence of surgical reconstruction was 85.4% (n = 27,805). Multivariable regression revealed that nonprivate insurance types were associated with lower likelihoods of operative reconstruction compared with private insurance: the lowest likelihood of operation was seen in uninsured patients (OR, 0.31; P < .01), followed by Medicare (OR, 0.33; P < .01) and Medicaid (OR, 0.51; P < .01) patients. There was also a decreased likelihood of surgery for elderly (OR, 0.0 [for age ≥75 years]; P < .01) and Black patients (OR, 0.65; P < .01). An increased likelihood of surgery was seen with female patients (OR, 1.14; P < .01). Patients in the highest median household income quartile were more likely to undergo surgery than those in the lowest (OR, 1.36; P < .01).

Conclusion:

Compared with privately insured patients, patients with nonprivate insurance had lower likelihood of surgery. Furthermore, patients in higher income quartiles were more likely to undergo operative fixation. These findings may suggest a need for more precise treatment guidelines and studies that investigate causes of such differences.
Otolaryngology Subspecialty Surgical Rescheduling Rates During the COVID‐19 Pandemic
Authors: Sagalow Emily S. , Duffy Alexander , Selvakumar Priyanga , Cognetti David M.
Published: March 2022

Objective

In the beginning of the COVID‐19 pandemic in spring 2020, elective and oncologic surgical cases were cancelled. After adequate safety protocols were established, each subspecialty within otolaryngology faced unique challenges in reengaging patients for surgical scheduling.

Study Design

Retrospective review from March to May 2020.

Setting

Single academic institution.

Methods

Patients whose otolaryngology surgery was cancelled due to COVID‐19 hospital precautions were identified. Rescheduling rates were analyzed by subspecialty. Case completion was determined as the percentage of initially cancelled cases that were completed within 6 months of their original planned dates.

Results

Of 833 otolaryngology cases scheduled between March 16 and May 29, 2020, a total of 555 (66.63%) were cancelled due to COVID‐19 precautions, and 71.17% were rescheduled within 6 months. Cancellation and rescheduling rates per subspeciality were as follows, respectively: head and neck surgery, 42.79% and 88.76%; sleep surgery, 83.92% and 64.07%; rhinology and skull base, 72.67% and 64.80%; facial plastic and reconstructive surgery, 80.00% and 74.17%; otology and neurotology, 71.05% and 66.67%; and laryngology, 68.57% and 79.17%. The case completion rates were as follows: head and neck surgery, 95.2%; laryngology, 85.7%; facial plastic and reconstructive surgery, 79.3%; otology and neurotology, 76.3%; rhinology and skull base, 74.4%; and sleep surgery, 69.9%.

Conclusion

Differences for surgical rescheduling rates during the COVID‐19 pandemic shutdown exist among otolaryngology subspecialties. Our experience suggests that subspecialties that functioned on an elective nature were more likely to face lower rates of case completion.
Contextualizing narratives of Geography’s past, present, and future: Synthesis, difference, and cybernetic control
Authors: Grove Kevin , Rickards Lauren
Published: March 2022

In this article, we seek to open up for critical debate disciplinary narratives that center the “synthesis” qualities of geographic thought. Proponents of Geography often emphasize its integrative, synthesis approach to human–environment relations to underline its value to interdisciplinary research initiatives addressing critical real-world issues such as climate change. But there are multiple styles of knowledge synthesis at work within academia and beyond, and they have contradictory ethical and epistemological effects. More specifically, synthesis is on the rise, but it is not Geography’s synthesis-as-understanding. Rather, an increasingly dominant cybernetic sociotechnical imaginary is installing a specific notion of synthesis—“synthesis-as-solution”—into universities, transforming both the production of knowledge and the institutional management and technological manifestation of that production. This cybernetic sociotechnical imaginary constrains research ethically and epistemologically to reduce knowledge to the synthesizable information flows and continuous innovation that characterize cybernetic control. In this context, non-conforming research—that is, research that disrupts or disdains such smooth synthesis—risks being labeled unprofessional, unimportant, and obsolescent and marginalized institutionally. Geographic disciplinary narratives that unreflexively celebrate synthesis thus risk producing a paradoxical future for Geography, one in which more space for different modes of knowledge production is created, but the type of difference recognized and affirmed is severely constrained. There is a pressing need for geographers to pay more attention to the practices and contexts in which we create disciplinary narratives because, like the content of our knowledge production, they can either challenge or reinforce a cybernetic sociotechnical imaginary.
Isolation, molecular detection and antimicrobial susceptibility profile of Salmonella from raw cow milk collected from dairy farms and households in southern Ethiopia
Authors: Gebeyehu Alemayehu , Taye Mestawet , Abebe Rahmeto
Published: March 2022

Background

Salmonella is one of the foodborne pathogens affecting public health around the globe. A cross-sectional bacteriological study was conducted from December 2019 to November 2020. This study aimed to isolate, molecularly detect and determine antibiotic susceptibility patterns of Salmonella from raw cows’ milk collected from dairy farms and households in Hawassa, Arsi Negele, and Dale districts.

Materials and methods

A total of 384 raw milk samples were collected using a simple random sampling technique. Standard bacteriological and biochemical tests were used to isolate Salmonella. The positive samples were further confirmed by the molecular test. Kirby-Bauer disk diffusion method was used for antimicrobial susceptibility testing of Salmonella.

Results

Using bacteriological and biochemical detection tests, Salmonella was isolated from 10.42% (N = 40) of the total sample. However, in molecular detection, only 32 of the 40 isolates were confirmed to be Salmonella using PCR test. The prevalence was 8.54, 12.69, and 10.46% in Hawassa, Dale, and Arsi Negele districts, respectively. Bacteriological prevalence did not vary significantly between the districts (P > 0.05). Likewise, no significant (P > 0.05) variation was observed in the Salmonella isolation rate between households (12.5%) and farms (8.33%) as well as between dry (8.85%) and wet (11.98%) seasons. Based on herd size, the isolation rate of Salmonella was significantly higher (P < 0.05) in large-scale farms (19.51%) than in small (5.1%) or medium (5.6%) scale dairy farms. The result of the antibiotic susceptibility test showed that Salmonella isolates were 100% resistant to ampicillin, while they were 100% sensitive to ciprofloxacin. Multi-drug resistance (MDR) was demonstrated in all isolates.

Conclusion

This study showed that Salmonella is widespread in the raw milk samples and developing MDR, which may be of public health concern in the study area. It is therefore important that dairy farmers and raw milk sellers in the study area take serious measures to avoid contamination of the milk with Salmonella spp. In addition, the active commitment of the animal health departments in the respective districts to sensitizing dairy farmers and the sensible use of antibiotics at the farm level can help to reduce the antibiotic resistance of Salmonella spp.
Time-series transcriptome comparison reveals the gene regulation network under salt stress in soybean (Glycine max) roots
Authors: Hu Junmei , Zhuang Yongbin , Li Xianchong , Li Xiaoming , Sun Chanchan , Ding Zhaojun , Xu Ran , Zhang Dajian
Published: March 2022

Background

Soil salinity is a primary factor limiting soybean (Glycine max) productivity. Breeding soybean for tolerance to high salt conditions is therefore critical for increasing yield. To explore the molecular mechanism of soybean responses to salt stress, we performed a comparative transcriptome time-series analysis of root samples collected from two soybean cultivars with contrasting salt sensitivity.

Results

The salt-tolerant cultivar ‘Qi Huang No.34’ (QH34) showed more differential expression of genes than the salt-sensitive cultivar ‘Dong Nong No.50’ (DN50). We identified 17,477 genes responsive to salt stress, of which 6644 exhibited distinct expression differences between the two soybean cultivars. We constructed the corresponding co-expression network and performed Gene Ontology term and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. The results suggested that phytohormone signaling, oxidoreduction, phenylpropanoid biosynthesis, the mitogen-activated protein kinase pathway and ribosome metabolism may play crucial roles in response to salt stress.

Conclusions

Our comparative analysis offers a comprehensive understanding of the genes involved in responding to salt stress and maintaining cell homeostasis in soybean. The regulatory gene networks constructed here also provide valuable molecular resources for future functional studies and breeding of soybean with improved tolerance to salinity.