bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Analysis of decreased Mental state Patients after Overdose with Sedative-hypnotics
Authors: Oh Seung Jae , Cho Soo Hyung , Ryu So Yeon
Published: June 2023

Purpose: This study was undertaken to investigate how sedative-hypnotics affect the occurrence and severity of the patient's symptoms. In addition, we conducted a study to determine the type of patients who reacted severely and required hospitalization; patients were accordingly classified as hospitalized patients and patients discharged from the emergency room. Methods: From January 2017 to December 2019, we investigated the demographics, drug information, history, laboratory tests, and severity of patients who visited our emergency department and were diagnosed with benzodiazepine, zolpidem, and doxylamine succinate overdose. We further compared details of hospitalized patients and discharged patients. Results: Subjects who had overdosed and visited the ED included 120 for benzodiazepine, 147 for zolpidem, and 27 for doxylamine succinate. Comparisons between the three groups revealed differences in their early diagnosis, psychiatric history, and sleep disturbance. Differences between groups were also determined for mental state, poisoning history, treatment received in the intensive care unit, and intubation and ventilator support. In cases of benzodiazepine overdose, we obtained a high hospitalization rate (40.0%), admission to the intensive care unit (24.2%), and intubation rate (18.3%). Comparisons between hospitalized patients and discharged groups showed differences in transferred patients, early diagnosis, and mental state. Conclusion: Patients poisoned by sedative-hypnotics are increasing every year. In cases of benzodiazepine and zolpidem, the hospitalization rates were high, and benzodiazepine overdose resulted in hospitalization, intensive care unit admission, and pneumonia in a majority of cases. Therefore, active treatment and quick decisions in the emergency room are greatly required.
Up-to-date treatment of acetaminophen poisoning
Authors: Sung Phil Chung , Jeongmi Moon , Byeongjo Chun
Published: June 2023

N-Acetylcysteine (NAC) is the standard antidote treatment for preventing hepatotoxicity caused by acetaminophen (AAP) poisoning. This review summarizes the recent evidence for the treatment of AAP poisoning. Several alternative intravenous regimens of NAC have been suggested to improve patient safety by reducing adverse drug reactions and medication errors. A two-bag NAC infusion regimen (200 mg/kg over 4 h, followed by 100 mg/kg over 16 h) is reported to have similar efficacy with significantly reduced adverse reactions compared to the traditional 3-bag regimen. Massive AAP poisoning due to high concentrations (more than 300-lines in the nomogram) needs to be managed with an increased maintenance dose of NAC. In addition to NAC, the combination therapy of hemodialysis and fomepizole is advocated for severe AAP poisoning cases. In the case of a patient presenting with an altered mental status, metabolic acidosis, elevated lactate, and an AAP concentration greater than 900 mg/L, hemodialysis is recommended even if NAC is used. Fomepizole decreases the generation of toxic metabolites by inhibiting CYP2E1 and may be considered an off-label use by experienced clinicians. Since the nomogram cannot be applied to sustained-release AAP formulations, all potentially toxic sustained-release AAP overdoses should receive a full course of NAC regimen. In case of ingesting less than the toxic dose, the AAP concentration is tested twice at an interval of 4 h or more; NAC should be administered if either value is above the 150-line of the nomogram.
Rhabdomyolysis induced by venomous snake bite
Authors: Jungho Lee , Jeongmi Moon , Byeongjo Chun
Published: June 2023

Purpose: Despite previous studies reporting the development of rhabdomyolysis (RM), this affliction tends to be neglected as an envenomation sign in South Korea. The current retrospective study investigates the prevalence and prognosis of RM after a snakebite. We further searched for predictors of snakebite-induced RM, which can be observed at presentation. Methods: This study included 231 patients who presented to the ED within 24 hours after a snakebite. The patients were classified according to the severity of RM, and the data, comprising baseline characteristics and clinical course including the level of creatine kinase (CK), were collected and compared according to the severity of RM. Results: The prevalence of RM and severe RM were determined to be 39% and 18.5%, respectively. Compared to the group without RM or with mild RM, the group with severe RM had a higher grade of local swelling, a higher frequency of acute kidney injury and neurotoxicity, and a greater need for renal replacement therapy and vasopressor administration. However, the incidence of acute renal injury in the RM group was 7.7%, with two patients needing renal replacement therapy. No mortalities were reported at discharge. Results of the multinomial logistic regression model revealed that the WBC levels are significantly associated with the risk of severe RM. Conclusion: RM should be considered the primary clinical sign of snake envenomation in South Korea, although it does not seem to worsen the clinical course. In particular, physicians should pay attention to patients who present with leukocytosis after a snakebite, which indicates the risk of developing RM, regardless of the CK level at presentation.
Prediction of pathogen positive-culture results in acute poisoning patients with suspected aspiration
Authors: Baek Sungha , Park Sungwook
Published: June 2023

Purpose: This study sought to compare the characteristics of patients with pathogen-positive and negative cultures, and to investigate factors predicting pathogen-positive culture results in patients of acute poisoning with suspected aspiration. Methods: Consecutive patients with acute poisoning admitted to an intensive care unit between January 2016 and December 2018 were retrospectively studied. Respiratory specimens were collected from the enrolled patients at the time of the suspected aspiration. We compared the characteristics of patients with pathogen-positive and negative culture results and analyzed the causative pathogens. Results: Among the 526 patients, 325 showed no clinical features that could be attributed to aspiration, and 201 patients had clinical features suggestive of aspiration. Of these, 113 patients had pathogen-positive culture, 61 were negative, and the specimens of 27 patients contained poor-quality sputum. In univariate analysis, patients with a positive culture showed a longer time to culture from ingestion (p=0.01), faster heart rate (p=0.01), and higher partial pressure of arterial oxygen to the fraction of inspired oxygen (PaO2/FiO2) (p=0.02) than patients with negative culture. Multivariate analysis demonstrated that PaO2/FiO2 (adjusted odd ratio, 1.005; 95% confidence interval [CI], 1.002-1.008; p=0.005) was a significant risk factor for pathogen-positive culture. The area under the receiver operating characteristic curve of PaO2/FiO2 was 0.591 (95% CI, 0.510-0.669, p=0.05). Gram-negative pathogens (GNPs) were predominant and at least one GNP was observed in 84 (73.3%) patients among those with pathogen positive culture. Conclusion: We failed to find any clinical factors associated with positive culture results. Antibiotics that cover GNPs could be considered when deciding the initial antibiotic regimen at the time of suspected aspiration.
Cardiac arrest and severe encephalopathy following e-cigarette nicotine intoxication: a case report
Authors: Jinwon Park , Sunghyun Yun
Published: June 2023

Traditionally, most cases of nicotine poisoning have been due to ingestion of nicotine pesticides. However, the increasing use of electronic cigarettes (e-cigarettes) has resulted in both intentional and unintentional exposure to concentrated liquid nicotine or “eliquid” leading to an increase in nicotine poisoning cases. However, fatalities following the ingestion of the e-liquid are extremely rare. We report a rare case of cardiac arrest and severe encephalopathy following the intentional ingestion of e-liquid. We present the case of a 20-year-old woman who intentionally ingested liquid nicotine intended for e-cigarette use. She was found in asystole and experienced a return of spontaneous circulation (ROSC) after undergoing approximately 46 mins of cardiopulmonary resuscitation. Her plasma nicotine levels were >500 ng/ml. Despite aggressive supportive care, she was found to have encephalopathy consistent with severe anoxic brain injury on magnetic resonance imaging. In recent times, there have been some reports of deaths following liquid nicotine ingestion. Our case illustrates the potential for fatal nicotine toxicity from ingestion of e-cigarettes.
A personalized medicine approach to optimize care for a pediatric cystic fibrosis patient with atypical clinical symptoms
Authors: Arora Kavisha , Lee Jesun , Husami Ammar , Zhang Weiqiang , Kadri Ferdous , Yarlagadda Sunitha , Moon Changsuk , Mun Kyu Shik , Zhang Kejian , Huang Yunjie , Liyanage Pramodha , Brewington John , Clancy John P. , Shaikhkhalil Ala , Paul Grace , Naren Anjaparavanda P.
Published: June 2023

Mutations in the cystic fibrosis (CF) transmembrane conductance
regulator (CFTR) gene typically cause severe health complications in
multiple organ systems, including the respiratory and gastrointestinal
systems. Certain CFTR mutations, however, cause milder clinical
phenotypes which may delay confirmatory diagnosis and treatment.
Moreover, rare CFTR variants are not studied frequently or
approved for genotype specific CFTR modulator therapies, creating
further disadvantage. Herein, we describe a personalized medicine
approach for a CF patient with three CFTR variants and mild
clinical disease to aid in the diagnosis of CF and development of an
optimized treatment plan. This strategy relied on the synergistic
combination of advanced genetic analyses, patient-derived models of CFTR
function and modulation, and personalized clinical care delivery. Whole
Exome Sequencing revealed three compound heterozygous CFTR
variants: c.2249C>T (p.P750L), c.1408G>A
(p.V470M), and c.1251C>A (p.N417K). The CFTR channel
function and nature of protein defects for both V470M and N417K
mutations are not previously characterized. Patient-derived intestinal
organoid models demonstrated residual CFTR channel activity, with
improvement in channel function following treatment with the CFTR
modulators. / n vitro studies in heterologous model system
demonstrated that P750L has the features of Class II CFTR mutations,
whereas V470M/N417K exhibited characteristics of Class II, III, and IV
mutations, with all three variants responding to the combination
modulator therapy of elexacaftor, tezacaftor, and ivacaftor (ETI) and
showing functional rescue to near-wild-type CFTR levels. The laboratory
data was then utilized to inform patient care, including off-label
prescription of ETI. Following 18 months of ETI therapy, significant
improvements were noted in key clinical outcomes, including sweat
chloride, nutritional parameters, and respiratory and gastrointestinal
symptoms. This study demonstrates a personalized medicine approach
across clinical and laboratory domains used to care for CF patients with
atypical symptoms and/or rare CFTR mutations.
Oscillometry and spirometry are not interchangeable when assessing the bronchodilator response in children and young adults born preterm
Authors: Bradshaw Tiffany K. , Smith Elizabeth , Urs Rhea C. , Evans Denby , Hemy Naomi R. , Hall Graham L. , Wilson Andrew , Simpson Shannon
Published: June 2023

Introduction: The European Respiratory Society Oscillometry
Taskforce identified that clinical correlates of bronchodilator
responses are needed to advance oscillometry in clinical practice. The
understanding of bronchodilator-induced oscillometry changes in preterm
lung disease is poor. Here we describe a comparison of bronchodilator
assessments performed using oscillometry and spirometry in a population
born very preterm and explore the relationship between
bronchodilator-induced changes in respiratory function and clinical
outcomes. Methods: Participants aged 6-23 born ≤32 (N=288; 132
with bronchopulmonary dysplasia) and ≥37 weeks’ gestation (N=76,
term-born controls) performed spirometry and oscillometry. A significant
bronchodilator response (BDR) to 400mcg salbutamol was classified
according to published criteria. Results: A BDR was identified
in 30.9% (n=85) of preterm-born individuals via spirometry and/or
oscillometry, with poor agreement between spirometry and oscillometry
definitions (k=0.26; 95%CI 0.18 to 0.40, p<0.001). Those born
preterm with a BDR by oscillometry but not spirometry had increased
wheeze (33% vs 11%, p=0.010) and baseline resistance (Rrs
z-score mean difference (MD)= 0.86, 95%CI 0.07 to
1.65, p=0.025), but similar spirometry to the group without a BDR (FEV
z-score MD= -0.01, 95%CI -0.66 to 0.68,
p>0.999). Oscillometry was more feasible than spirometry
(95% vs 85% (FEV ), 69% (FVC), p<0.001),
however being born preterm did not affect test feasibility.
Conclusion: In the preterm population, oscillometry is a
feasible and clinically useful supportive test to assess the airway
response to inhaled salbutamol. Changes measured by oscillometry reflect
related but distinct physiological changes to that measured by
spirometry and thus these tests should not be used interchangeably.
Assessment of Morphology of Patent Foramen Ovale Associated with Cryptogenic Stroke
Authors: Li Ling , Pu Hong , Zhang Qing , Wu Jing , Zhang Yuan , Zhao Yaxi
Published: June 2023

Background: Patent foramen ovale (PFO) is the correlation with
migraine headaches, cryptogenic stroke. The transcatheter closure of PFO
has been proven effective preventing cryptogenic stroke (CS), it is
necessary to determine the structure of PFO associated with CS. This
study aimed to detect the morphological and function of PFO by using
transesophageal echocardiography (TEE) and contrast transthoracic
echocardiography (c-TTE) to assess the morphology of PFO associated with
CS, and seek out the high-risk factors of PFO for CS. Methods:
113 test patients who suffered CS combining with PFO and 117 control
patients diagnosed PFO without stroke were enrolled. The structure of
PFO were detected by TEE and c-TTE. The following parameters were
measured by TEE: the length and height of the PFO tunnel during
Valsalva, the presence of atrial septal aneurysm (ASA), the angle
between inferior vena cava (IVC) and PFO, and thickness of septum
secundum, and the severity of right-to-left (RLS) was tested by c-TTE.
The differences structure of PFO between the test patients and controls
were compared, and the correlation between the PFO parameters and CS in
test group was analyzed. Based on logistic analyses, we sought out the
high-risk factor of PFO for CS. Results: The patients of test
group were older than that of control group (56 [48-67.5] years vs
42 [31-51] years, P < 0.001). The height of the PFO
during Valsalva (2.5[2-3] mm vs 2.1[1.6-2.8] mm, P =
0.022) were found to be greater in test group than those in control
group. The length of the PFO during Valsalva (13.03 ± 4.18 mm vs 11.35 ±
3.84, P = 0.002) were found to be greater in test group than
those in control group. The low-angle PFO( the angle between IVC and PFO
≤ 10°) was more common in patients with CS than those in control (48
(42.5%) vs 13 (11.1%)， P＜0.001). Besides, the occurrence rate
of ASA in test group is more frequently compared with control group (20
(18%) vs 9(8%), P =0.022). RLS III during Valsalva in test
group (85 (75.2%)) was significantly higher than that in control group
(70 (59.8%)). RLS II during Valsalva in the without CS group (36
(30.8%)) was significantly higher than that in the CS group (18
(15.9%)). There was no difference between the two groups for RLS I
during Valsalva and all grades of RLS at rest. There was no significant
difference regarding the thickness of septum secundum as well.
Multivariate analysis showed that the length of the PFO during Valsalva,
the presence of ASA, RLS III during Valsalva, and the low-angle PFO were
independently relevant factors for CS. Conclusions: The
relation between PFO and CS is multifactorial. The length of the PFO
tunnel, the low-angle PFO, RLS III during Valsalva and the presence of
ASA were the greater risk for CS, The TEE combined with c-TEE may help
in identifying PFO that is of high risk for CS and screening out the
patients for transcatheter closure of PFO.
Analysis of Clinical and Pathological Features of Omicron Variants of SARS-CoV-2 associated Kidney Injury
Authors: Zhu Xuejing , Qi Zhiwen , Yuan Shuguang , Wei Jinying , Xia Shiyu , Huang Yao , Chen Xiaojun , Han Yachun , Li Zheng , Xiao Yang , FenghuaPeng * , Fu Xiao , Sun Lin , Liu Hong
Published: June 2023

Kidney injury is common in patients with Coronavirus Disease-19
(COVID-19). In this study, 49 patients with Omicron associated kidney
injury were included, 38 of whomperformed renal biopsy. Patients were
divided into 2 groups: Group A for patients developing kidney injury
afterSARS-CoV-2 infection and Group B for patients with aggravated renal
insufficiency after SARS-CoV-2 infection. The clinical, pathological and
prognostic characteristicsof the patients and theirC3 levels were
observed.In our center, the clinical diagnoses of patients with COVID-19
associated kidney injury were mainly acute kidney injury(AKI), chronic
kidney disease(CKD) and nephrotic syndrome(NS); while the pathological
diagnoses were mainly IgA nephropathy(IgAN)、focal segmental
glomerulosclerosis(FSGS) and membranous nephritis(MN).80% of COVID-19
associated nephropathy (COVAN) patients had normal serum C3 complement
level, and a few patients had increased or decreased C3 level. In renal
tissue, C3 deposits were observed in 68.4% of patients.29% of patients
experienced deterioration of renal function after treatment, but no
patients developed to end-stage renal disease (ESRD). Among all of them,
one case presenting with thrombotic microangiopathy (TMA) had a more
severe renal pathological lesion and poorer prognosis. We observed
differences of clinical and pathological features of patients with
COVID-19associated kidney injury between races, regions and virus
variants. Asian patients with Omicron associated kidney injury have
milder kidney injury and a better renal prognosis.
A systematic review, meta-analysis, dose-response, and meta-regression of the effects of acarbose intake on glycemic markers in adults
Authors: Dehkordi Sina Raissi , Pahlavani Naseh , Nikbaf-Shandiz Mahlagha , Bagheri Reza , Rasaei Niloufar , Darzi Melika , Rastgoo Samira , Shiraseb Farideh , Asbaghi Omid
Published: June 2023

Background: Prior research has yielded mixed results regarding the
impact of acarbose intake on glycemic markers. To provide a more
comprehensive analysis, a systematic review and meta-analysis was
performed to compile data from various randomized controlled trials
(RCTs) examining the effects of acarbose intake on fasting blood sugar
(FBS), insulin, hemoglobin A1C (HbA1c), and homeostasis model assessment
of insulin resistance (HOMA-IR) in adults. Methods: To identify relevant
literature up to April 2023, a comprehensive search was conducted on
various scholarly databases, including PubMed, Web of Science, and
Scopus databases. The effect size of the studies was evaluated using a
random-effects model to calculate the weighted mean differences (WMD)
and 95% confidence intervals (CI). Heterogeneity between studies was
assessed using Cochran’s Q test and I2. Results: This systematic review
and meta-analysis included a total of 101 RCTs with a total of 107
effect sizes. The effect sizes for FBS in milligrams per deciliter
(mg/dl), insulin in picomoles per liter (pmol/l), hemoglobin A1C (HbA1c)
in percentage (%), and homeostasis model assessment of insulin
resistance (HOMA-IR) were 92, 46, 80, and 22, respectively. The pooled
analysis indicated that acarbose intake resulted in significant
decreases in FBS (p=0.018), insulin (p<0.001), HbA1c
(p<0.001), and HOMA-IR (p<0.001). Conclusion: The
findings of this systematic review and meta-analysis suggest that
acarbose intake can potentially lead to significant improvements in
glycemic indices by decreasing the levels of FBS, HbA1c, and insulin.
However, larger and more rigorously designed studies are still needed to
further evaluate and strengthen this association.
The effect of divergent and parallel selection on the genomic landscape of divergence
Authors: Ali Hisham , Coulson Tim , Clegg Sonya , Quilodrán Claudio
Published: June 2023

While the role of selection in divergence along the speciation continuum
is theoretically well understood, defining specific signatures of
selection in the genomic landscape of divergence is empirically
challenging. Modelling approaches can provide insight into the potential
role of selection on the emergence of a heterogenous genomic landscape
of divergence. Here, we extend and apply an individual-based approach
that simulates the phenotypic and genotypic distributions of two
populations under a variety of selection regimes, genotype-phenotype
maps, modes of migration, and genotype-environment interactions. We show
that genomic islands of high differentiation and genomic valleys of
similarity may respectively form under divergent and parallel selection
between populations. For both types of between-population selection,
negative and positive frequency-dependent selection within populations
generated genomic islands of higher magnitude and genomic valleys of
similarity respectively. Divergence rates decreased under strong
dominance with divergent selection, as well as in models including
genotype-environment interactions under parallel selection. For both
divergent and parallel selection models, divergence rate was higher
under an intermittent migration regime between populations, in contrast
to a constant level of migration across generations, despite an equal
number of total migrants. We highlight that interpreting a particular
evolutionary history from an observed genomic pattern must be done
cautiously, as similar patterns may be obtained from different
combinations of evolutionary processes. Modelling approaches such as
ours provide an opportunity to narrow the potential routes that generate
the genomic patterns of specific evolutionary histories.
Visioning synthetic futures for yeast research within the context of current global techno-political trends
Authors: Pretorius Isak , Dixon Thomas A. , Walker R.S.K.
Published: June 2023

Yeast research is entering into a new period of scholarship, with new
scientific tools, new questions to ask, and new issues to consider. The
politics of emerging and critical technology can no longer be separated
from the pursuit of basic science in fields, such as synthetic biology
and engineering biology. Given the intensifying race for technological
leadership, yeast research is likely to attract significant investment
from government, and that it offers huge opportunities to the curious
minded from a basic research standpoint. This article provides an
overview of new directions in yeast research, and places these trends in
their geopolitical context. At the highest level, yeast research is
situated within the ongoing convergence of the life sciences with the
information sciences. This convergent effect is most strongly pronounced
in areas of AI-enabled tools for the life sciences, and the creation of
synthetic genomes, minimal genomes, pan-genomes, neochromosomes and
metagenomes using computer assisted design tools and methodologies.
Synthetic yeast futures encompass basic and applied science questions
that will be of intense interest to government and non-government
funding sources. It is essential for the yeast research community to map
and understand the context of their research in order to ensure their
collaborations turn global challenges into research opportunities.
Estimated effects of clear-cuts and burns associated with habitat use by female Newfoundland Caribou (Rangifer tarandus)
Authors: Dekelaita Daniella , Krausman Paul , Mahoney Shane
Published: June 2023

The decline of Caribou (Rangifer tarandus) is mainly attributed to anthropogenic disturbance from resource development (i.e., logging, oil and gas extraction), which causes habitat loss and increased predation risk. Natural landscape disturbance, particularly from fire, can have similar effects, and cumulative effects from disturbance have been associated with lower neonate recruitment. Our objective was to evaluate the potential effects of land cover types on resource selection by females, with an emphasis on clear-cuts and fire, during the calving season (May–June) in three neighbouring herds (Middle Ridge, Gaff Topsails, and Pot Hill) on insular Newfoundland, Canada, and compare results with pre-existing information on calf recruitment. We applied a resource selection framework to analyze location data collected from global positioning system collars between 2007–2010 and estimate relative probability of use for different cover types. Recruitment was lowest in Pot Hill, where ≤10-year old clear-cuts were favoured, whereas recruitment was highest in Middle Ridge and Gaff Topsails, where females favoured burns, suggesting that burns could be more beneficial to Caribou fitness. Further investigation will be needed to more closely examine how anthropogenic versus natural disturbance affects Caribou fitness in Newfoundland and improve our understanding of important habitat for calving females.
A characterization of S-pseudospectra of linear operators in a Hilbert space
Authors: Ammar Aymen , Bouchekoua Ameni , Jeribi Aref
Published: June 2023

In this work, we introduce and study the S-pseudospectra of linear operators defined by nonstrict inequality in a Hilbert space. Inspired by A. B?ttcher?s result [3], we prove that the S-resolvent norm of bounded linear operators is not constant in any open set of the S-resolvent set. Beside, we find a characterization of the S-pseudospectrum of bounded linear operator by means the S-spectra of all perturbed operators with perturbations that have norms strictly less than ?.
Some applications of p-(DPL) sets
Authors: Alikhani Morteza
Published: June 2023

In this paper, we introduce a new class of subsets of class bounded linear operators between Banach spaces which is called p-(DPL) sets. Then, the relationship between these sets with equicompact sets is investigated. Moreover, we define p-version of Right sequentially continuous differentiable mappings and get some characterizations of these mappings. Finally, we prove that a mapping f : X ? Y between real Banach spaces is Fr?chet differentiable and f? takes bounded sets into p-(DPL) sets if and only if f may be written in the form f = 1?S where the intermediate space is normed, S is a Dunford-Pettis p-convergent operator, and g is a G?teaux differentiable mapping with some additional properties.
Characterisations of the radical in a Banach algebra
Authors: Raubenheimer Heinrich , Lukoto Tshikhudo
Published: June 2023

In this paper we characterise the radical in a Banach algebra A in terms of the perturbation ideal P(R) of a set R in A.
Magnetic Frenet curves on para-Sasakian manifolds
Authors: Bejan Cornelia-Livia , Binh Tran , Druţă-Romaniuc Simona-Luiza
Published: June 2023

The study of magnetic curves, seen as solutions of Lorentz equation, has been done mainly in 3-dimensional case, motivated by theoretical physics. Then it was extended in higher dimensions, as for instance in K?hlerian or Sasakian frame. This paper deals for the first time in literature with magnetic Frenet curves in higher dimensional paracontact context. Several classifications are provided here for different types of magnetic curves on para-Sasakian manifolds. Some relations between magnetic Frenet curves and Lorenz force are obtained on these spaces and examples of magnetic curves associated to paracontact magnetic fields are constructed. Some explicit equations of the paracontact magnetic curves on the classical para-Sasakian manifold (R2n+1, ?, ?, ?, 1) are given at the end.
Fredholm linear relation and some results of demicompact for multivalued matrix linear operator
Authors: Ammar Aymen , Jeribi Aref , Saadaoui Bilel
Published: June 2023

The main purpose of this article is to give a relationship between Fredholm multivalued linear operators and the demicompact linear relation; we provide some sufficient conditions on the inputs of a closable block multivalued linear operator matrix to ensure the generalized demicompactness of its closure. Our results generalize many known ones in the literature.
Existence of mountain-pass solutions for p(・)-biharmonic equations with Rellich-type term
Authors: Laghzal Mohamed , Touzani Abdelfattah
Published: June 2023

This manuscript discusses the existence of nontrivial weak solution for the following nonlinear eigenvalue problem driven by the p(?)-biharmonic operator with Rellich-type term {?(|?u|p(x)?2?u) = ?|u|q(x)?2u/?(x)2q(x), for x ? ?, u = ?u = 0, for x ? ??. Considering the case 1 < min x?? p(x) ? max x?? p(x) < min x?? q(x) ? max x?? q(x) < min (N 2, Np(x) N ? 2p(x) ), we extend the corresponding result of the reference [8], for the case 1 < min x?? q(x) ? max x?? q(x) < min x?? p(x) ? max x?? .p(x) < N 2 . The proofs of the main results are based on the mountain pass theorem
Existence result for fractional q-difference equations on the half-line
Authors: Ülke Öyküm , Topal Fatma
Published: June 2023

In this paper, we obtain an existence result for the integral boundary value problems of nonlinear fractional q-difference equations on the half-line using Schauder?s fixed point theorem.
Compact operators on Cesàro sequence spaces and norms of Cesàro operators
Authors: İlkhan Kara Merve , Roopaei Hadi
Published: June 2023

This paper deals with the characterization of compact operators on Ces?ro sequence spaces as an application of Hausdorff measure of noncompactness. Further, the norms of Ces?ro operators on certain spaces are investigated.
On the superposition operator in the space of functions of Hωq ([0,1])
Authors: Karami Sajjad , Fathi Javad , Ahmadi Ahmad
Published: June 2023

In this paper, we obtained a necessary and sufficient condition for the embedding H?q([0,1])? IBVqp([0,1]), where IBVq p denotes the set of functions of bounded q-integral p-variation. Additionally, the conditions for the composition and superposition operators were provided to map the space H?q([0,1]) into itself, by which these operators were bounded. Finally, we applied these results to examine the existence and uniqueness of solutions to Hammerstein integral equations in the space of H?q([0,1]).
Induction of KLF2 by exercise activates eNOS to improve vasodilatation in diabetic mice
Authors: Luo Jiang-Yun , Kwong Cheng Chak , Gou Lingshan , He Lei , Zhao Lei , Zhang Yang , Wang Li , Wai Lau Chi , Xu Aimin , F. Chen Alex , Huang Yu
Published: June 2023

Diabetic endothelial dysfunction associated with diminished endothelial nitric oxide synthase (eNOS) activity accelerates the development of atherosclerosis and cardiomyopathy. However, the approaches to restore eNOS activity and endothelial function in diabetes remain limited. The present study shows that enhanced expression of KLF2, a shear stress-inducible transcription factor, effectively improves endothelial function through increasing NO bioavailability. KLF2 expression is suppressed in diabetic mouse aortic endothelium. Running exercise and simvastatin treatment induce endothelial KLF2 expression in db/db mice. Adenovirus-mediated endothelium-specific KLF2 overexpression enhances both endothelium-dependent relaxation and flow-mediated dilatation while it attenuates oxidative stress in diabetic mouse arteries. KLF2 overexpression increases the phosphorylation of eNOS at serine 1177 and eNOS dimerization. RNA-sequencing analysis reveals that KLF2 transcriptionally upregulates genes that are enriched in the cGMP-PKG signaling pathway, cAMP signaling pathway, and insulin signaling pathway, all of which are the upstream regulators of eNOS activity. Activation of the PI3K-Akt pathway and Hsp90 contributes to KLF2-induced increase of eNOS activity. The present results suggest that approaches inducing KLF2 activation such as physical exercise are effective to restore eNOS activity against diabetic endothelial dysfunction.
6 compared with 12 weeks treatment in the von Rosen splint is sufficient for Barlow and Ortolani positive hips: a comparative study of 237 neonates
Authors: Sand Adam , Tiderius Carl Johan , Düppe Henrik , Wenger Daniel
Published: June 2023

Background and purpose: At our institution, newborns with Barlow or Ortolani positive hips have been treated for 12 weeks with the von Rosen abduction splint until 2012 when the treatment length was halved. We investigate whether acetabular development at 12 months of age and complications differ between hips treated with the von Rosen splint for 6 compared with 12 weeks.Patients and methods: 99 patients were included in the 6-week program and 138 patients in the 12-week program. We measured the acetabular index (AI) on standard anteroposterior pelvic radiographs taken at 12 months of age. Medical records were reviewed for complications and additional treatments until age 12 months. We used non-inferiority testing with an equivalence margin of 1° with a 95% confidence interval (CI) to compare the 2 groups.Results: The mean AI at 12 months in the 6-week group was 25° (CI 24–26) compared with 25° (CI 25–26) in the 12-week group. Non-inferiority was demonstrated for the 6-week program: –0.2° (CI –1.1 to 0.7). In the 6-week group, 8 patients received additional treatment, including 1 hip dislocation that occurred between 6 weeks and 3 months. There were no additional treatments or complications in the 12-week group.Conclusion: AI was equal at 12 months of age for patients treated for 6 compared with 12 weeks in the von Rosen splint. The hip dislocation which occurred indicates that follow-up around 3 months of age is indicated.
Achievement Motivation and Self Efficacy in Measuring Student Adversity Quotient
Authors:   Universitas Negeri Semarang, Puji Astuti Dwi , Kardiyem Kardiyem , Nuraini Siti
Published: June 2023

This study aims to examine and analyze the effect of achievement motivation on adversity quotient, the effect of self-efficacy on adversity quotient, and the effect of achievement motivation and self-efficacy on adversity quotient in Economic Education students of Semarang State University. This study used a type of quantitative approach. The population in this study is students of the Department of Economic Education, Semarang State University class of 2017-2020, totaling 437 students. The sampling technique in this study used purposive sampling. The method of collecting and collecting data using questionnaire questionnaires of achievement motivation scale, self-efficacy scale, and adversity quotient scale that has been tested for validity and reliability. Data analysis techniques in this study use classical assumption testing models, path analysis and coefficient of determination (R2) tests. The results showed that there was no effect of achievement motivation on the adversity quotient of economic education students, there was an influence of self-efficacy on the adversity quotient of economic education students, and furthermore there was no effect of achievement motivation and self-efficacy on the adversity quotient of economic education students.
Leading through Partnership
Authors: Habing Kelda , Ruan Lian
Published: June 2023

In the over three decades since its establishment in 1990, the Illinois Fire Service Institute (IFSI) Library has been a leader through taking the initiative in developing and maintaining partnerships for the benefit of its primary user community: the firefighters of Illinois. Partnerships at the local, state, national, and international levels have allowed the IFSI Library to respond to the unique information needs of firefighters through the creation and continued use of services and programs which have been created specifically to meet these unique needs, and the IFSI Library’s place within the Illinois state fire academy allows these services and programs to be promoted and made available to firefighters across the state. By taking the initiative to create partnerships for the benefit of firefighters, the IFSI Library has established itself as a leader in partnership with both the library and information science field as well as to the fire service. The services and programs made possible through the IFSI Library’s partnerships have contributed to Illinois firefighters’ ability to access the information and resources that they need to continue keeping their communities safe.
Nopeus valttina ja taakkana: Uutiskuvajournalismin ammattilaisten harjaantunut näkeminen
Authors: Mäenpää Jenni
Published: June 2023

Mediatyö on reaaliaikaistunut ja kuvamäärät ovat kasvaneet valtavasti digitalisoitumisen jälkeen, mikä vaatii ammattilaisilta kykyä tehdä nopeita mutta eettisiä päätöksiä. Median välittämät uutiskuvat ovat tärkeä osa ihmisten arkea ja visuaalista kulttuuriamme, koska ne laajentavat ymmärrystämme kaukana olevista asioista ja samalla muokkaavat käsitystämme todellisuudesta. Kuvajournalismin ammattilaisilla on suuri valta ja vastuu siitä, miten jäsennämme maailmaa. Tässä artikkelissa tarkastellaan, mitä visuaalinen ammattitaito tarkoittaa kuvajournalismin ammattilaisten – erityisesti uutiskuvatoimittajien – nopeatempoisessa työssä. Empiirinen aineisto on kerätty havainnoimalla ja haastattelemalla kuvajournalismin ammattilaisia uutiskuvatoimistoissa Reutersilla ja STT-Lehtikuvassa. Tässä poikkitieteellisessä tutkimuksessa yhdistetään teoreettista keskustelua näkemisen ja kognition etnografisesta tutkimuksestaja journalismin tutkimuksesta. Analyysin tuloksena löytyi neljä kuvajournalistisen työn osa-aluetta, joissa ammattimainen näkeminen harjaantuu ja palvelee erityisesti nopeatempoista uutistyötä. Näitä ovat ennakoimaan oppiminen uutisia ja aiemmin julkaistuja kuvia seuraamalla, kuvaustilanteiden ennakointi ja keskittynyt katsominen, teknologian hyödyntäminen ja kuvista käydyt keskustelut. Johtopäätöksenä esitetään, että ammattilaisten kesken jaettu, harjaantunut näkeminen on kuvajournalistien professionaalisuuden keskeinen edellytys, mutta samaan aikaan se saattaa aiheuttaa mediakuvaston yhdenmukaistumista. Samanlainen vaikutus on todettu olevan myös nopeuden ja uutisvoittojen tavoittelulla uutistyössä.
Suomalaisen mediatutkimuksen historiaa 12: Mediatutkimuksen metodologinen tutkimus: marxilais-systemaattisesta positivistis-historialliseen metodiin
Authors: Malmberg Tarmo
Published: June 2023

Suomalaisen mediatutkimuksen historiaa -sarjassa esitellään tekijänsä uran tai alan kehityksen kannalta merkille pantavia töitä. Tarkoitus on samalla herättää kiinnostusta kotimaisen tutkimuksen historiaan, jonka kokonaisesitys on edelleen laatimatta.

Numerossa 2/2019 alkanut kirjoitussarja päättyy tähän.

Veikko Pietilä. Tiedotustutkimus: teitä ja tienviittoja. Tampere: Tampereen yliopisto, tiedotus- opin laitos, 1982.

Veikko Pietilä. Joukkoviestintätutkimuksen valtateillä: tutkimusalan kehitystä jäljittämässä. Tampere: Vastapaino, 1997.
Datakapitalismin uhka ja lumo
Authors: Nikunen Kaarina
Published: June 2023

Timo Harakka. 2022. Datakapitalismi kriisien maailmassa. Helsinki: Siltala. 168 s.
The Impact of Financial Ratios on Bank Performance Before and During COVID-19: Evidence from Bank Business Activities Category 3 and 4 in Indonesia
Authors: Kamal Aqila Gabrita
Published: June 2023

Keeping in mind the year 2020 until the end of 2022, the COVID-19 pandemic and its economic turmoil shocked banking sectors. The COVID-19 pandemic has caused significant disruptions to economies across the globe, and Indonesia is no exception. As a result, the banking sector in Indonesia has been particularly affected. This research aims to investigate the banking situation in Indonesia during COVID-19 and how it has affected bank profitability (ROA). Profitability is a ratio that measures the company's ability to generate profits. Return on Assets (ROA) is one of the profitability ratios. Return on assets (ROA) is a commonly used financial ratio that measures a company's profitability. For this research, the dependent variable is return on asset to measure bank profitability. The independent variables are non-performing loan, net interest margin, operating expense to operating income, loan-to-deposit ratio, and capital adequacy ratio. This research also uses control variables. The control variables in this research are bank size, GDP growth, inflation, and interest rates. Since this research also aims to investigate the effect of the COVID-19 pandemic on banks' profitability. The covid-19 pandemic is also an independent variable used as a dummy. The sample used in this research are commercial banks business activity category 3 and 4. The methodology of this research utilises panel data and a two-step system GMM. Thus, this research has discovered that COVID-19 affected ROA negatively and significantly. Additionally, the financial ratios that affected ROA are NIM and OEOI.
PENGEMBANGAN ASSESSMENT BERBASIS VIDEO PADA KOMPETENSI DASAR MENGANALISIS SIMPANAN DANA DEPOSITO DI SMK NEGERI 1 TEMPEL KELAS X TAHUN AJARAN 2019/2020
Authors: Priharsanti Rosita Nur Wahyuningtyas , Prijowuntato Sebastianus Widanarto
Published: June 2023

This research aims to create and develop a video-based assessment product in Basic Banking Course to teach the basic competence number 3.9, i.e. Time Deposits, to the tenth grade Accounting students and to determine the feasibility of the learning products based on media experts, assessment experts, linguists, accounting learning practitioners, and students’ responses. This research is a research and development (RD) consisting of 8 stages, namely : 1) research and information collection, 2) planning, 3) developing preliminary from of product 4) preliminary field testing, 5) main product revision, 6) main field testing, 7) final product revision, 8) dissemination and implementation. The media were validated by a media expert, an assessment expert, a linguist, and an accounting teacher in SMK Negeri 1 Tempel. The media was tested on 47 tenth grade Accounting students of SMK Negeri 1 Tempel. The results showed that the level of feasibility of the video-based assessment product was categorized 1) as “feasible” based on the validation of assessment experts, with a mean score of 3.72; 2) as “strongly feasible” based on the validation of media experts, with a mean score of 4.17 ; 3) as “strongly feasible” based on the validation of linguists, with a mean score of 4.26; 4) and as “strongly feasible” based on the validation of accounting learning practitioners, with a mean score of 4.8. Student showed a positive response to this assessment product after being tested as shown in the observation sheet. Thus, the video-based learning product is feasible to be used in Accounting learning, especially Basic Banking Course discussing Basic Competence number 3.9: Time Deposits.
HUBUNGAN PELAKSANAAN PEMBELAJARAN MENGGUNAKAN MEDIA ZOOM MEETING DENGAN PRESTASI BELAJAR MAHASISWA PADA MASA PANDEMI COVID-19
Authors: Hutabarat Widia Wati , Suratno Ignatius Bondan
Published: June 2023

This study aimed to determine the correlation between: 1) the use of Zoom Meetings and students’ learning achievement during the Covid-19 pandemic; and 2) complete zoom meeting facilities and students’ learning achievements during the Covid-19 pandemic. This research was a quantitative study that was conducted in May-June 2021. The population in this study were students of the Economic Education Study Program specializing in Accounting Education, Sanata Dharma University Yogyakarta, Batch of 2017-2019. The samples in the study were 105 students taken by purposive sampling technique. The research data were collected using questionnaires distributed through Google form and tested using Spearman’s rank correlation. The test results showed that: 1) there was no correlation between the use of zoom meetings and students’ learning achievements during the Covid-19 pandemic as indicated by the correlation coefficient value of -0.142 and the probability of sig.(2-tailed) = 0.149; and 2) there was no correlation between the completeness of the Zoom Meetings facilities and students’ learning achievement during the Covid-19 pandemic as indicated by the correlation coefficient value of -0.140 and the probability of sig.(2-tailed) = 0.154.Keywords: Learning implementation, Zoom Meeting media, and students’ achievements.
Morphological peculiarities of regeneration of oral mucosa associated with use of polymeric piezoelectric membranes
Authors: Koniaeva AD , Varakuta EYu , Leiman AE , Rafiev DO , Bolbasov EN , Stankevich KS
Published: June 2023

Wound defects of the oral mucosa are a common pathology the treatment of which often involves synthetic membranes. Development of varieties of such membranes is an ongoing process. This study aimed to register morphological features of the oral mucosa regeneration process in the presence of one of the varieties, the polymer piezoelectric membranes. The study involved 45 Wistar rats divided into 3 groups: 1) animals with an open wound defect; 2) animals with a wound defect covered with a copper-coated polymer membrane; 3) intact animals. The samples for morphometric study were collected on the 3rd, 7th and 12th days. On the 3rd day, rats of group 1 had the specific area of granulation tissue 1.4 times greater than that in group 2 (p = 0.033). In group 1 rats, endotheliocytes expressed more VEGF than in the animals of group 2. In group 2, the defect was ultimately completely covered with the epithelial layer, which was not the case in group 1. On the 7th day, the epithelium in rats of group 2 was twice as thick as the layer registered in group 1 (p = 0.019). Granulation tissue was replaced by loose fibrous connective tissue. In group 1, the specific area of inflammatory infiltration was greater than that of loose fibrous connective tissue, and the VEGF expression level was lower than in group 2. On the 12th day, the predominant tissue in group 2 was the loose fibrous connective tissue, the VEGF expression level equaled that of group 3, and peripheral nerves began to grow. In group 1, the specific area of dense fibrous tissue was 3.9 times greater than that in group 2 (p = 0.012), the epithelium had pathological changes and the VEGF expression was below control values. Thus, a polymer piezoelectric membrane had a positive effect on the post-wound restoration of the oral mucosa tissues.
Archiving Tradition: Role of Primetime Soaps as a Tool to (Re)Construct Tradition
Authors: Augustine Alphonse
Published: June 2023

Archives tell us more about individuals, institutions, customs and cultures. They increase our sense of identity and understanding of cultures by telling old stories, narratives, histories and travel tales. Women have a significant role in modern culture. The vital role woman can play in improving themselves, their family, and society is being established via efforts. The advancement and development of civilization are largely driven by women. They are essential components of a thriving society needed for the advancement of the country. Regarding women, television has a very high level of communication effectiveness. Their thoughts, beliefs, and attitudes are significantly shaped and influenced by television especially the primetime soaps. This paper aims to investigate how women are portrayed in popular Indian soap operas and how do they reconstruct and digitize new tradition.