bluuebunny/crossref_metadata_2025 huggingface dataset:
First fluorescent acetylspermidine deacetylation assay for HDAC10 identifies selective inhibitors with cellular target engagement
Authors: Herp Daniel , Ridinger Johannes , Robaa Dina , Shinsky Stephen A. , Schmidtkunz Karin , Yesiloglu Talha Z. , Bayer Theresa , Steimbach Raphael R. , Herbst-Gervasoni Corey J. , Merz Annika , Romier Christophe , Sehr Peter , Gunkel Nikolas , Miller Aubry K. , Christianson David W. , Oehme Ina , Sippl Wolfgang , Jung Manfred
Published: March 2022

Histone deacetylases (HDACs) are important epigenetic regulators involved in many diseases, especially cancer. Five HDAC inhibitors have been approved for anticancer therapy and many are in clinical trials. Among the 11 zinc-dependent HDACs, HDAC10 has received relatively little attention by drug discovery campaigns, despite its involvement, e.g., in the pathogenesis of neuroblastoma. This is due in part to a lack of robust enzymatic conversion assays. In contrast to the protein lysine deacetylase and deacylase activity of most other HDAC subtypes, it has recently been shown that HDAC10 has strong preferences for deacetylation of oligoamine substrates like acetyl-putrescine or -spermidine. Hence, it is also termed as a polyamine deacetylase (PDAC). Here, we present the first fluorescent enzymatic conversion assay for HDAC10 using an aminocoumarin-labelled acetyl-spermidine derivative to measure its PDAC activity, which is suitable for high-throughput screening. Using this assay, we identified potent inhibitors of HDAC10-mediated spermidine deacetylation in vitro. Based on the oligoamine preference of HDAC10, we also designed inhibitors with a basic moiety in appropriate distance to the zinc binding hydroxamate that showed potent inhibition of HDAC10 with high selectivity, and we solved a HDAC10-inhibitor structure using X-ray crystallography. We could demonstrate selective cellular target engagement for HDAC10 but a lysosomal phenotype in neuroblastoma cells that was previously associated with HDAC10 inhibition was not observed. Thus, we have developed new chemical probes for HDAC10 that allow further clarification of the biological role of this enzyme.
Criminal Liability for Theft of Non-Cash and Electronic Funds Under the Criminal Legislation of the Republic of Kazakhstan and the Russian Federation: a Comparative Legal Analysis
Authors:   Eastern Law Institute (branch) of the University of Prosecutor’s Office of the Russian Federation, Antonova E. Y. , Klimenko A. K. ,   Eastern Law Institute of the Ministry of Internal Affairs of the Russian Federation
Published: March 2022

The issues of constructing norms on liability for theft of non-cash and electronic money are considered on the example of the legislation of the Republic of Kazakhstan and Russia. The article analyzes the criminal legislation of the Republic of Kazakhstan and Russia, the normative resolution of the Supreme Court of the Republic of Kazakhstan dated December 11, 2020 No. 6 “On amendments and additions to some normative decisions of the Supreme Court of the Republic of Kazakhstan”, which regulates the provision on liability for the theft of non-cash and electronic funds in a new way, committed by a special entity ‒ by embezzlement and embezzlement with the use of the guilty official position. It is concluded that it is possible and expedient to borrow the experience of the Republic of Kazakhstan, namely, the need to present “electronic fraud” in the form of qualified fraud, thereby leading to uniformity with the composition of “electronic theft”, given their equal degree of increased public danger, and the exclusion of Art. 1593 from the Criminal Code of the Russian Federation.
Recherche im Translationsprozess : Ein Lehr- und Studienbuch
Authors: Hagermann Suzanne
Published: March 2022

What do I need to know in order to handle a translation job appropriately? How do I find out what I need? That's what research is all about. Gaps in one's knowledge can exist in very different areas - for example, in language or cultural competence, in technological competence, in background knowledge of the subject area, in information about the assignment, or even in familiarity with the requirements of professional practice. This study- and textbook accompanies students through the various phases of research, from determining research needs, to finding appropriate tools, to evaluating possible solutions, to documenting research results for later use. Numerous examples and illustrations provide clarity.
Clinical, imaging spectrum and outcome of PRES
Authors:   Assistant Professor, NRI Academy of Medical Sciences, Chinakakani, Guntur, Andhra Pradesh 522503, INDIA., Meduri Praveen Chowdary
Published: March 2022

Background: Posterior reversible encephalopathy syndrome (PRES), also called the acute hypertensive encephalopathy and reversible leukoencephalopathy syndrome (RPLS), is a clinico-radiological syndrome presents with rapid onset of headache, seizures, loss of consciousness, visual loss and characterized by white matter vasogenic edema affecting parietal and occipital lobes of the brain predominantly. However, the imaging findings are variable and may occur in other locations such as the frontal lobes, thalami, basal ganglia and brainstem. Objective: To study the clinical, imaging spectrum and final disease outcome of PRES Materials And Methods: The study was conducted on 52 patients who presented with clinical features and radiological diagnosis of PRES The clinical, imaging features and outcome of each patient were analyzed Results: The study was conducted on 52 patients with age range from below 10yrs to 65 yrs. Patients presented with various symptoms of which seizures(84.6%) is most common followed by headache(59.6%), vomiting (36.5%), visual disturbances(32.7%), altered sensorium(15.3%), thalamic aphasia (5.7%), hemiparesis(3.8%), paresthesia(3.8%), ataxia(3.8%), Quadriparesis (3.8%) and facial numbness (1.9%) is the least. On MR imaging typical parieto-occipital lobe involvement(98%)is seen in most of the cases, however other atypical regions involved were frontal lobe(52%),temporal lobe (17.3%), cerebellum (27%),thalamus (15.3%), brainstem (13.4%), basal ganglia (9.6%) and corpus callosum (1.9%) Lesions in atypical locations also had lesions in typical locations in all cases except in one case of central PRES. Dominant parieto-occipital pattern was seen in 32%,superior frontal sulcus pattern in 27%,holohemispheric pattern in 34.6%,Partial or asymmetric expression of primary patterns in 5.2% cases Diffusion restriction and postcontrast enhancement was seen in less than 25% cases. Complete resolution of symptoms was seen in 90.5% cases,3.8% of them succumbed to death. On follow up 5.7% of cases showed persistence of symptoms. Conclusion: PRES is a clinico-radiological syndrome with varied clinical and imaging spectrum. Involvement of atypical regions is not uncommon. However lesions in atypical locations often have lesions in typical locations also.Atypical imaging features like restricted diffusion and contrast enhancement are also not uncommon. Knowledge of atypical lesion location, atypical imaging features is necessary for the clinicians and radiologists not to misdiagnose PRES in the appropriate clinical setting
Aktivitas Antibakteri Ekstrak Kulit Buah Kakao (Theobroma cacao L.) terhadap Bakteri Propionibacterium acnes
Authors: Adha Selvira Dwi , Ibrahim Muslimin
Published: March 2022

Jerawat adalah peradangan pada kulit yang sering diderita masyarakat di negara tropis. Keberadaan Propionibacterium acnes dapat memicu timbulnya jerawat. Antibiotik digunakan sebagai obat jerawat, akan tetapi penggunaannya dalam jangka waktu yang panjang menyebabkan efek samping berupa resistensi bakteri. Kulit buah kakao (Theobroma cacao L.) mempunyai kandungan metabolit sekunder berupa flavonoid, alkaloid, tannin, dan saponin sehingga dapat digunakan sebagai antibiotik alami. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak kulit buah kakao terhadap bakteri P. acnes dan konsentrasi yang menghasilkan daya hambat paling tinggi. Metode maserasi digunakan pada tahapan ekstraksi dengan menggunakan etanol 96%. Metode sumuran digunakan untuk pengujian aktivitas antibakteri. Konsentrasi ekstrak yang digunakan yakni 25%, 50%, 75%, dan 100%. Kontrol positifnya menggunakan klindamisin 0,1%, sedangkan kontrol negatifnya menggunakan DMSO 10%. Hasil yang diperoleh adalah terbentuknya zona hambat dengan diameter paling besar dihasilkan oleh konsentrasi 100% dengan rata-rata sebesar 3,25 ± 0,33 cm dan diameter zona hambat paling kecil dihasilkan oleh konsentrasi 25% dengan rata-rata sebesar 1,38 ± 0,41 cm. Konsentrasi ekstrak 100% memiliki daya hambat tertinggi dalam menghambat pertumbuhan P. acnes. Ekstrak kulit buah kakao berpengaruh dalam penghambatan pertumbuhan P. acnes.
Aktivitas Antibakteri Ekstrak Kulit Buah Kakao (Theobroma cacao L.) Terhadap Staphylococcus epidermidis
Authors: Lestari Helda Dwiya , Asri Mahanani Tri
Published: March 2022

Staphylococcus epidermidis termasuk dalam genus bakteri Staphylococcus yang banyak ditemukan pada infeksi kulit. Pemberian antibiotik pada penyakit kulit yang tidak tepat akan menaikkan tingkat resistensi bakteri. Peningkatan daya resistensi bakteri terhadap antibiotik, memyebakan dilakukan eksplorasi sumber senyawa bioaktif pada bahan alam di Indonesia, salah satunya kakao. Kulit buah kakao adalah bagian yang tidak termanfaatkan dalam pengolahan biji kakao, dan diketahui mengandung senyawa bioaktif dari metabolit sekunder yang memiliki sifat antibakteri. Tujuan penelitian yaitu untuk menguji aktivitas antibakteri dan konsentrasi terbaik ekstrak kulit buah kakao dalam menghambat pertumbuhan S. epidermidis. Penelitian dilakukan menggunakan metode sumuran yang didesain menggunakan rancangan acak lengkap (RAL) dengan berbagai perlakuan antara lain konsentrasi ekstrak kulit buah kakao 25%, 50%, 75%, 100%, kontrol positif (amoksilin), dan kontrol negatif (DMSO 10%). Data rerata clear zone yang dihasilkan konsentrasi 25%, dan 50% menunjukkan ada perbedaan nyata setiap perlakuan, sedangkan konsentrasi 75% dan 100% tidak menunjukkan perbedaan nyata. Konsentrasi terbaik yang didapatkan adalah 75% dengan rerata zona hambat terbesar, yaitu 2,85 ± 0,42 cm. Ekstrak kulit buah kakao diketahui memiliki aktivitas antibakteri yaitu dari penghambatan pertumbuhan bakteri S. epidermidis.
Kemampuan Lemna minor dalam Menurunkan Kadar Linear Alkyl Benzene Sulphonate
Authors: Fitriana Nuril , Kuntjoro Sunu
Published: March 2022

Limbah detergen merupakan salah satu limbah cair terbesar penyebab pencemaran pada perairan yang berasal dari aktivitas domestik maupun industri. Bahan kimia berupa Linear Alkyl Benzene Sulphonate (LAS) dalam detergen dapat mencemari lingkungan. Salah satu upaya yang dapat dilakukan untuk mengurangi kandungan detergen di dalam perairan adalah dengan metode fitoremediasi menggunakan tumbuhan Lemna minor. Tujuan penelitian ini adalah untuk mendeskripsikan kemampuan L. minor dalam menurunkan kadar LAS. Penelitian ini merupakan penelitian eksperimental dengan menggunakan Rancangan Acak Kelompok (RAK) dengan dua faktor yaitu konsentrasi LAS (0 ppm, 10 ppm, 20 ppm dan 30 ppm) dan lama waktu kontak yang berbeda (5 hari dan 10 hari). Dalam penelitian ini terdapat 4 kali pengulangan dengan total 32 unit perlakuan. Parameter yang diamati meliputi kadar LAS dan biomassa basah akhir. Data yang diperoleh dianalisis menggunakan ANAVA dua arah dan dilanjutkan dengan uji Duncan. Hasil penelitian menunjukkan bahwa  penurunan kadar LAS detergen terbesar ada pada waktu kontak 10 hari dan pada konsentrasi LAS 30 ppm sebesar 83,2%.  Pada perlakuan lama waktu kontak 10 hari menunjukkan peningkatan biomassa basah lebih besar dibandingkan dengan perlakuan lama waktu kontak 5 hari.
Pengaruh Pemberian Senyawa Epigallocatechine gallate (EGCG) terhadap Penurunan Kadar Glukosa Darah dan Histopatologi Testis Mencit Diabetes Melitus Induksi Alloxan monohydrate
Authors: Hilmi Alfinda Ayurista , Budijastuti Widowati
Published: March 2022

Penelitian ini bertujuan untuk mendeskripsikan pengaruh pemberian senyawa Epigallocatechine gallate (EGCG) dalam menurunkan kadar glukosa darah dan histologi testis mencit induksi Alloxan monohydrate. Hewan coba yang digunakan sebanyak 24 ekor mencit jantan galur BALB/c yang dibagi menjadi 6 kelompok perlakuan, yaitu kelompok kontrol negatif (A), kontrol positif (B), Alloxan+glibenclamide (C), Alloxan+EGCG 7 mg/kgBB (D), Alloxan+EGCG 14 mg/kgBB (E) dan Alloxan+EGCG 21 mg/kgBB (F) masing-masing terdiri atas 4 ekor mencit. Pengukuran kadar glukosa darah dilakukan pada hari ke- 0, 7, 14, dan 21 setelah pemberian perlakuan. Kadar gula darah puasa dianalisis menggunakan Anova dan didapatkan hasil signifikansi 0,012<0,05 kemudian dilanjutkan dengan  uji Duncan yang menunjukkan bahwa ketiga kelompok dosis EGCG memiliki perbedaan aktivitas antidiabetes yang signifikan. Skoring histopatologi testis dan diameter tubulus seminiferus dianalisis menggunakan uji Kruskal Wallis dan dilanjutkan dengan uji Mann Whitney. Hasil penelitian menunjukkan rata-rata penurunan kadar glukosa darah pada kelompok C, D, E dan F berturut-turut sebesar 9,50; 30,00; 51,50; dan 53,25 mg/dl, sedangkan pada kelompok A dan B tidak mengalami penurunan (-1,0 dan -30,25 mg/dl). Rata-rata skoring histopatologi spermatogenesis testis kelompok A, B, C, D, E dan F secara berturut adalah 7,0; 8,2; 8,6 dan  8,6 serta rata-rata diameter tubulus seminiferus pada kelompok A; B; C; D; E dan  F adalah 86 µm; 45 µm; 52 µm; 60 µm; 70 µm dan  82 µm. Dari data tersebut dapat disimpulkan bahwa senyawa EGCG berpengaruh terhadap penurunan kadar gula darah dan histopatologi testis dengan dosis 21 mg/kg BB yang menghasilkan penurunan sebesar 33,34%.
Keanekaragaman dan Kemelimpahan Bivalvia di Zona Intertidal Pantai Boom, Tuban
Authors: Hidayah Nurul , Ambarwati Reni
Published: March 2022

Bivalvia merupakan salah satu penyusun komunitas makrozoobentos di kawasan pesisir pantai. Dalam ekosistem, bivalvia berperan sebagai pemakan suspensi dan deposit serta menjadi mangsa (prey). Pantai Boom merupakan kawasan pantai utara di Kabupaten Tuban berprofil landai dan dikembangkan untuk wisata. Penelitian ini bertujuan untuk mendeskripsikan keanekaragaman bivalvia, mendeskripsikan kemelimpahan bivalvia, dan menganalisis profil habitat bivalvia di Pantai Boom Tuban. Sampel bivalvia diambil dengan metode belt transect yang ditentukan empat stasiun dengan 240 plot. Profil habitat yang dikaji adalah pH air, pH substrat, salinitas, suhu, dan tipe substrat.  Data hasil penelitian yang diperoleh kemudian dianalisis secara statistik deskriptif. Hasil penelitian menunjukkan bahwa bivalvia yang ditemukan di zona intertidal Pantai Boom Tuban meliputi Tellina timorensis, Tellina palatum, Siliqua winteriana, Solen sp., Anadara rufescens, Harvella plicataria, Mactra violacea, Mactra grandis, Meretrix lusoria, Meretrix meretrix, Marcia hiantina, Crassostrea gigas, dan Ciboticola lunata. Nilai indeks keanekaragaman bivalvia di Pantai Boom Tuban yaitu 1,513. Kemelimpahan relatif bivalvia tertinggi di Pantai Boom Tuban adalah Tellina timorensis, yaitu sebesar 48,34% dan terendah pada Marcia hiantina, dan Ciboticola lunata, yaitu sebesar 0,15%. Profil habitat bivalvia di Pantai Boom Tuban adalah pH air 7,3 ± 0,75, pH substrat 6,5 ± 0,30, salinitas 24-28%o ± 1,75, suhu 31ºC ± 0,91, dan tipe subtrat pasir lanau. Habitat ini dapat mendukung komunitas bivalvia di Pantai Boom Tuban.
Penggunaan Canva pada Pembelajaran Berbasis Proyek untuk Meningkatkan Keterampilan dan Motivasi Menulis Siswa
Authors: Purwanti Eko
Published: March 2022

Motivasi dan keterampilan menulis menjadi hal yang menarik untuk diketahui oleh semua guru. Salah satu tugas menulis untuk siswa kelas delapan adalah menulis kartu ucapan. Penelitian ini bertujuan untuk menguji apakah penggunaan Canva dalam pembelajaran berbasis proyek dapat meningkatkan motivasi dan keterampilan menulis siswa. Subjek Penelitian Tindakan Kelas (PTK) ini adalah 30 siswa kelas VIIIE di SMPN I Terbanggi Besar tahun pelajaran 2019/2020 yang terdiri dari 10 laki-laki dan 20 perempuan. Teknik pengumpulan data dilakukan dengan memberikan angket untuk mengetahui motivasi siswa dan tugas menulis untuk mengetahui keterampilan menulis siswa. Penelitian ini dilakukan dalam dua siklus. Temuan pada siklus I dan siklus II menunjukkan bahwa nilai siswa untuk aspek motivasi dan menulis meningkat. Nilai rata-rata untuk tingkat motivasi siswa adalah 59,9 pada penelitian pendahuluan, 74,1 pada siklus I dan 84,9 pada siklus II. Nilai rata-rata menulis siswa adalah 56,7 pada penelitian pendahuluan, 69,3 pada siklus I dan 79,6 pada siklus II. Ini dapat disimpulkan bahwa penggunaan canva pada pembelajaran berbasis projek dapat meningkatkan keterampilan dan motivasi menulis siswa.
Project Based Learning pada Literasi Sains Berbasis Budaya Lokal Bahari dengan Penggunaan Alat Wind Detection
Authors: Kahiking Eka Candra
Published: March 2022

The natural phenomenon of the sea about the wind that is still not taken up in science learning and learning media is needed. To understand the phenomenon, scientific literacy is needed, it is necessary for the creativity of the teacher. The aim is to improve students' scientific literacy skills and obtain teaching aids that can be used in local maritime and 21st-century culture-based learning. Learning activities are carried out using a project-based learning model combined with scientific literacy stages using a Bluetooth digital wind detection tool. learning media is developed and validated by experts, learning stages are developed according to needs, scientific literacy skills are obtained based on observations of scientific literacy skills, interviews, response questionnaires, and product assessments at 80 to 100%, are in the good and very good categories. It is concluded that this learning innovation can improve students' scientific literacy skills, and produce teaching aids that utilize local culture based technology according to the demands of the 21st century learning that can be used in science learning in everyday life to help the community.
Pembuatan Animasi Drawing untuk Meningkatkan Kemampuan Basic dan Technology Literacy Siswa SMPN Unggulan Sindang
Authors: Herlina Elin
Published: March 2022

Penelitian ini bertujuan untuk meningkatkan kemampuan Basic dan Technology Literacy siswa kelas VIII I SMPN Unggulan Sindang melalui pembuatan Animasi Drawing dalam Pembelajaran Berbasis Proyek. Metode Penelitian Kualitatif dalam bentuk Penelitian Tindakan Kelas. Subjek penelitian siswa VIII I berjumlah 33 orang. Teknik pengumpulan data menggunakan Lembar Observasi, Lembar Penilaian Produk, Tes Tertulis dan Angket. Hasil penelitian kemampuan Basic Literacy pada Siklus I menghasilkan produk peta konsep diperoleh nilai rata-rata 79, nilai tertinggi 90, nilai terendah 75, dan kelulusan 61%. Pada Siklus II menghasilkan produk Storyline Animasi Drawing nilai rata-rata 89, nilai tertinggi 98, nilai terendah 80, dan kelulusan 100%. Kemampuan Technology Literacy dinilai pada Siklus II diperoleh  produk siswa membuat Video Animasi Drawing kemudian diunggah di Youtube. Hasilnya nilai rata-rata 88,94, nilai tertinggi 98, nilai terendah 80, dan kelulusan 100%. Hasil belajar kognitif dengan KBM 78 pada Siklus I nilai rata-rata 79, nilai tertinggi 98, nilai terendah 38 dan kelulusan 67%, sedangkan pada Siklus II nilai rata-rata 84, nilai tertinggi 98, nilai terendah 63 dan kelulusan 82%. Sikap siswa terhadap pembuatan Animasi Drawing yaitu 4 orang apresiasi tinggi, 19 orang sedang, dan 7 orang rendah. Penelitian ini membuktikan bahwa dengan pembuatan Animasi Drawing kemampuan Basic dan Technology Literacy siswa meningkat.
Penguatan Modal Sosial melalui Program Nasional Pemberdayaan Masyarakat
Authors: Muliana Lia , Mustaqim Muammar
Published: March 2022

Kelompok Simpan Pinjam Perempuan (SPP) adalah bagian dari Program Nasional Pemberdayaan Masyarakat (PNPM) yang diluncurkan pada Tahun 2007. Program ini ditujukan oleh pemerintah untuk mengentaskan kemiskinan, meningkatkan pendapatan masyarakat, dan mensejahterakan masyarakat miskin. Desa Cot Peradi adalah salah satu desa di Kecamatan Suka Makmue Kabupaten Nagan Raya, yang menjalankan program kelompok Simpan Pinjam Perempuan. Tujuan penulisan jurnal ini untuk mengetahui dan menjelaskan efektivitas program kelompok SPP di Desa Cot Peradi, mengetahui modal sosial mempunyai peranan yang penting demi keberlangsungan program Simpan Pinjam Perempuan. Tujuan lainnya untuk menjelaskan bahwa modal sosial yang dibentuk masyarakat dalam program kelompok SPP berdampak terhadap penurunan angka kemiskinan di Kabupaten Nagan Raya. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif. Hasil penelitian mengemukakan bahwa kelompok Simpan Pinjam Perempuan di Desa Cot Peradi berjalan dengan optimal sebagaimana tujuan awal dari program ini, dikarenakan masyarakat mampu membentuk modal sosial yang baik, sehingga dapat meningkatkan pendapatan masyarakat dan menurunkan angka kemiskinan.
Sustainable Development Aims for HE : What goals do they have to reach and where are they now?
Authors: Szendrei-Pál Eszter
Published: March 2022

Resources of our planet are limited. If humanity would like to protect it and leave behind a better place for the next generations than we got from our parents, a sustainable way of thinking must be involved in the everyday life. Currently, the goal is to influence as many individuals as possible and teach them to make sustainable choices. The solution can be in our educational system. The main goal of this paper is to collect and systematize current programs, their content in connection with HE sustainable development and introduce the associations, which support these changes. The paper will contain a SWOT assessment of Budapest Business School's sustainability strategy, and hopefully, it could be a guidance for other HEIs where to start their changes.
The Private Market in Eastern Europe: Microbusinesses as a solution to unemployment and Private Insurances as a solution to poor medical service
Authors: Džidić Adin
Published: March 2022

Microbusiness, a possible way to solve the problem of unemployment in eastern Europe? Regarding the topic of microbusiness, an ancient day which has been around for centuries now, many people have in fact seen them as the “go-to” way as to solve problems of general unemployment which has plagiarized most of the world today. The general idea of microbusiness goes as: if one can’t find a desired position, one should indeed strive and their best to create it. However, this has proven itself on numerous occasions that it was much easier said than done, as starting a microbusiness does yield numerous risks of its own, with the major one being falling into bankruptcy as well as inadvertently falling into a legal affair. (Heyes, 2019) The former has indeed proven itself to be much more of a general danger for those who engage in this idea unprepared, while the latter might prove itself to be signifying a greater danger for those business which survive the initial stage which may last for a few months up to a few years at the time.
Organisational learning and sustainability
Authors: Benkó Aliz
Published: March 2022

Objectives: Finding a connection between organisational learning, learning organisations and interorganisational learning. Presentation of the inter-organisational learning model. I investigated the extent to which the factor of sustainable development is present in the healthcare markets of 4 European countries where procurement takes place through central tenders. With this in mind, I have realised what results effective inter-organisational learning may bring in terms of sustainability. Methodology: Targeted analysis and processing of 3 literature reviews in terms of theoretical background to find common ground between organisational learning, learning organisations and interorganisational learning. Content analysis of the tender documentation of the 4 selected countries with a regard to sustainability criteria. Among companies operating in the healthcare sector. Findings: Definitions of organisational learning most often include statements about the following key concepts: action and behaviour, learning and knowledge. In the definitions of learning organisations, the following 5 broad areas can be identified where researchers perform the definition of the concept: Learning, Organisational Structure, Shared Vision, Knowledge Management, Strategy, which means that learning and knowledge management are common. The elements of behaviour and learning return in the model of sustainable inter-organisational learning, with the addition that effective inter-organisational cooperation is subject to the existence of trust between the cooperating parties. Research/practical implications: I conducted a content analysis in the EU countries where healthcare procurement is carried out through tenders. I searched for the requirements and criteria for sustainability in the invitations to tender and also determined their proportion in the tender as a whole. In each of the countries examined, this constituted no more than 5-6%. Originality/value: The research draws attention to the need for trust in inter-organisational sustainability learning. The research identifies as a further research direction the health sector as one of the most dynamically developing sectors for the implementation of inter-organisational sustainability learning.
PDL-1 Expression in Inverted Papilloma
Authors: Günizi Hüseyin , Gunizi Ozlem Ceren
Published: March 2022

Background/Aim: PDL-1 is a ligand that cells involved in the pathogenesis of diseases use to protect themselves from the immune system. It has been reported that it can be used in the treatment. This immune pathway may also be effective
in inverted papilloma. Therefore, we aimed to show the presence of PDL-1 in inverted papillomas in our study. Methods : It is a case-control study. There were 14 patients with histopathological diagnosis of inverted papilloma in
study group and 14 patients with normal histopathological diagnosis of nasal mucosa after functional septoplasty and conchaplasty surgery in control group, between 2010 and 2021 were included. Results: The mean age was 40.23 years
in the study group and 29.1 years in the control group. Inverted papillom group consisted of 10 men and 4 women and control group consisted of 6 men and 8 women. The pdl-1 staining rates was higher in the inverted papilloma group
and iıt was statistically significantly (P<0.001). There was no statistically significant correlation between pdl-1 positivity and recurrence rates (p=0.840). Conclusion: PDL-1 was increased in sinonasal inverted papillomas.
Therefore, we think PDL-1 and PD-1 autoantibodies may be an alternative treatment option as an alternative to PDL-1 Surgery in sinonasal inverted papillomas.
Forage Potential of Plant Species Found in Various Ecosystems in Musi Banyuasin Regency, South Sumatera, Indonesia
Authors: Kanny Putri Irene , Chozin M.A. , Santosa Edi , Guntoro Dwi , Zaman Sofyan , Suwarto Suwarto , Kurniawati Ani
Published: March 2022

Forage is an important component in sustainable smallholder livestock. The purpose of the study was to identify the diversity of natural plant species in various ecosystems, as well as their potential as forage. Based on our surveys of palm oil plantation, rubber plantation, and home gardens using the quadrant method, we identified approximately 50 species comprising the natural vegetation of our study area. Out of 50, we identified 39 broad-leaved species, 9 grasses (Poaceae) species, and 2 sedges (Cyperaceae) species. The palm oil plantation had 29 species dominated by Ottochloa nodosa (11.92%) and Asystasia gangetica (11.40%); 25 species were found in the rubber plantation dominated by Cynodon dactylon (28.42%) and Panicum repens (9.20%), and home gardens contained 30 species dominated by Eleusine indica (13.39%) and Ageratum conyzoides (9.60%). Among the 29 species found in the palm oil plantation, 13 were observed to have low palatability scores, and 16 species have high palatability scores. Based on their high palatability scores, the following species can be utilized as forage for Balinese cattle: Cyrtococcum acrescens, Eleusine indica, Centrosema pubescens, Paspalum conjugatum, and Sida rhombifolia.
Sistem Prediksi Jumlah Penumpang Di Bandar Udara Juanda Surabaya Dengan Metode Double Exponential Smoothing
Authors: Setia Budi Agus , Hadi Susilo Purnomo
Published: March 2022

Bandar udara merupakan salah satu infrastruktur penting yang diharapkan dapat mempercepat pertumbuhan ekonomi masyarakat. Bandar udara berfungsi sebagai simpul pergerakan penumpang atau barang dari transportasi udara ke transportasi darat atau sebaliknya, salah satunya adalah Bandar Udara Internasional Juanda. Namun perlu dilakukan manajemen yang baik pada bandar udara karena kurangnya penjadwalan yang tertata. Dibutuhkan sistem untuk mengurangi kesalahan yang sering terjadi dan sistem yang mendukung. Penelitian ini bertujuan untuk menangani dan memberikan solusi terbaik untuk mengatasi permasalahan perhitungan jumlah penumpang pesawat di Bandar Udara Internasional Juanda.Dalam hal ini penulis mengadakan penelitian tentang prediksi calon penumpang pesawat pada Bandar Udara Internasional Juanda menggunakan metode Double Exponential Smoothing yang nantinya diharapkan dapat memberikan solusi terhadap permasalahan perhitungan penumpang pesawat untuk memprediksi calon penumpang pesawat sehingga dapat ditentukan penjadwalan yang tepat dengan jumlah pesawat yang diperlukan.Implementasi sistem ini menggunakan website dengan framework codeigniter dengan tingkat akurasi hasil mencapai 98% didukung dengan pola data yang sesuai, dalam hal ini data jumlah penumpang pertahun memiliki pola data statis yang mengandung data trend. Tingkat akurasi data diperoleh dari metode testing menggunakan Mean Absolute Percentage Error yang hasilnya kurang dari 25%.
Stalled high-pressure weather systems
Authors: Burl Henry
Published: March 2022

Stalled High Pressure Weather Systems (SHPWS) are associated with abnormally high temperatures, low wind velocities (except at their peripheries, where they can be quite high), cloudless skies, and a consequent lack of precipitation. Analysis shows that the high temperatures and clear skies associated with their formation are caused by the settling out of reflective (dimming) atmospheric Sulfur Dioxide (SO2) aerosols within the area of a “High”. This cleansing of the atmosphere allows sunshine to strike the Earth’s surface with greater intensity, resulting in substantially increased warming.
SOSIALISASI PEMBERDAYAAN UMKM “UMKM BANGKIT BERSINERGI”
Authors: Erin Soleha  , Erina Rulianti  , Fiqih Maria
Published: March 2022

MSMEs are one of the factors that affect the rate of economic growth, but many problems are faced, namely the licensing of their businesses. Sukamahi Village has several Micro, Small and Medium Enterprises (MSMEs) that have developed but there are still many that do not have permits such as not having a Business Identification Number (NIB) and Micro Small Business Permit (IUMK). The author made observations and interviews with business owners before holding this MSME empowerment socialization. The results of this service open the mindset of business owners about the importance of having business legality.
Thyroid Pathology in High-Risk Cardiac Surgery Patients with Coronary Artery Disease
Authors: Gogayeva Olena K. , Rudenko Anatoliy V. , Lazoryshynets Vasyl V. , Rudenko Serhii A. , Andrushchenko Tetiana A.
Published: March 2022

The aim. To analyze the features of the perioperative period in high-risk cardiac surgery patients with coronary artery disease (CAD) and thyroid disease.

Materials and methods. Retrospective analysis of data of 354 high-risk patients with CAD who were operated and discharged from the National Amosov Institute of Cardiovascular Surgery of the NAMS of Ukraine from 2009 to 2019. All the patients underwent standard clinical and laboratory tests, ECG, echocardiography, coronary angiography and surgical myocardial revascularization with correction of concomitant cardiac pathology. Ultrasound screening of thyroid disease and thyroid hormone levels was not performed in all patients, however, patients with severe symptoms were referred for follow-up.

Results. Thyroid disease was diagnosed in 37 (10.4%) patients, of whom 11 (3.1%) had hypothyroidism and were receiving hormone replacement therapy, and 1 (0.28%) had hyperthyroidism on tyrosol therapy. Ultrasound signs of thyroiditis were detected in 7 (1.9%) patients, nodular goiter in 29 (8.1%), and retrosternal goiter in 1 (0.28%) patient. Dependingonthecardiacsurgicalpathology,theprevalenceofhypothyroidismdidnotdifferinpatientswithuncomplicated and complicated forms of CAD (7 [3.6%] and 4 [2.5%] patients, respectively, p = 0.5498). Patients with hypothyroidism received hormone replacement therapy with levothyroxine in a dosage prescribed by an endocrinologist. The day before the surgery, thyroid-stimulating hormone control was performed to confirm the achievement of compensation. When comparing the course of the operative period in compensated hypothyroidism and clinical euthyroidism, no significant differences were found, and the postoperative period didn’t differ in the occurrence of atrial fibrillation (p = 0.0801), hydrothorax (p = 0.5280), but a decrease in the estimated glomerular filtration rate at discharge was found in patients with hypothyroidism (59.5 ± 16.8 vs. 71.3 ± 19.6 ml/min/1.73 m2, p = 0.0493).

Conclusions. Timely detection of thyroid dysfunction allows to compensate the condition and avoid postoperative complications. Analysis of the perioperative period in patients with hypothyroidism showed no effect of compensated hypothyroidism on the operative and postoperative periods in high-risk patients with CAD. Decreased glomerular filtration rate after surgery in patients with hypothyroidism requires further study and adherence to the strategy of nephroprotection in polymorbid patients.
Teachers’ Professional Identity Construction: A review of the literature
Authors: Pérez Gracia Elisa , Serrano Rodríguez Rocío , Pontes Pedrajas Alfonso
Published: March 2022

The construction of teachers’ professional identity (TPI) is a key issue in current research, so a wide range of scholars has focused their interest on that topic. Its construction and evolution are influenced by a wide range factors (personal, professional and contextual) along the initial training period. This review aims to know how TPI within initial training among Secondary Education teachers evolves, how teacher training programs approach it and which elements may influence its development. Therefore, a meta-analysis was used to examine the existing literature between 1990 and 2019. A total of 35 research studies were analysed showing an increase temporal tend coinciding in the definition of the main term (TPI) and the need to train it within initial training as well as the influence of determining factors in its construction, so they develop their commitment with future career. To conclude, this work makes a useful and updated contribution to the field and it brings insights regarding where investigation should go further in order to meet educational needs and societal demands.
Equipos profesionales, conflicto y complejidad en la intervención social
Authors: Martínez-González Alejandro , Zamanillo-Peral Teresa
Published: March 2022

Este trabajo es un ensayo sobre la necesidad de abordar los retos a los que se enfrentan los equipos profesionales de la intervención social en la época de la complejidad. Invita a alejarse de la concepción positivista de la realidad única y a reconocer la dimensión subjetiva que conduce al abandono de la posición de experto. Profundiza, además, en los retos de los equipos de trabajo y se detiene en la dimensión del conflicto y su abordaje como un factor inherente a la práctica profesional socioterapéutica y socioeducativa. Finalmente, anima a explorar nuevas formas de afrontar el liderazgo y la organización del trabajo y los equipos en pro de la mejora de su eficiencia y su eficacia, en las que prima la corresponsabilidad.
URINARY INCONTINENCE IN YOUNG AND NULLIPAROUS WOMEN: ASSOCIATED FACTORS AND PREVALENCE
Authors: Ferreira Erica Elice Lessa , Silva Filho Jabiael Carneiro da , Valença Marília Perrelli , Santos Isabel Cristina Ramos Vieira
Published: March 2022

Objective: To verify the prevalence and risk factors associated with urinary incontinence in nulliparous young women. Methods: Integrative literature review, performed by searching the following databases: Medical Literature Analysis and Retrieval System Online (MEDLINE), Latin American and Caribbean Literature in Health Sciences (LILACS), Spanish Bibliographic Index in Health Sciences (IBECS) and in the Nursing Database (BDENF), from March to June 2021, using the descriptors: “urinary incontinence”, “prevalence”, “women”, “students” and “young adult” combined with the Boolean operator “AND”. Results: The initial search resulted in 234 articles and, after applying the eligibility criteria, a final sample of 5 articles was obtained. After the analyses, a prevalence of urinary incontinence in young nulliparous women of 48% was evidenced. Risk factors were: high-impact physical activity, duration of physical activity, concomitant bowel and urinary symptoms. Conclusion: It was observed that the occurrence of urinary incontinence in nulliparous young women is a common condition. The associated risk factors demonstrate the need for health guidance to these women to avoid the chronification of the disease.
PENERAPAN MODEL PEMBELAJARAN INKUIRI TERBIMBING UNTUK MENINGKATKAN PENGUASAAN KONSEP IPA SISWA PADA MATERI CAHAYA DAN OPTIK
Authors: Syahfira Revi , Permana Niki Dian , Susilawati Susilawati , Azhar Azhar
Published: March 2022

This study aims to obtain an overview of improving students' mastery of science concepts through the application of guided inquiry learning models on light and optical materials. The research was conducted using a quasi-experimental method with the nonequivalent control design. The population of this study was all students of class VIII at one MTs in Pekanbaru city with a sample of two classes with a sampling technique in the form of purposive sampling. Data collection was carried out using a test instrument for mastery of science concepts on light and optical materials. Hypothesis testing was carried out using the independent sample t test. The results showed that the increase in students' mastery of science concepts in the experimental class was better than the control class where the normalized gain average score  of students in the experimental class was 76.12 in the high category while the control class was 60.01 in the medium category. Based on the hypothesis test, it was concluded that there was a significant difference in students' increasing mastery of science concepts between the experimental class that applied the guided inquiry learning model and the control class that applied the conventional learning model on light and optical materials.
Pengaruh Media Kartu Angka (Flash Card) Terhadap Peningkatan Pemahaman Konsep Bilangan pada Anak Autism
Authors: Fitria Rosda Ayu , Naimah Naimah , Diana Raden Rachmy
Published: March 2022

Meningkatkan kemampuan peserta didik dalam mengenal konsep angka degan cara mengganti strategi yang biasa dilakukan dikelas dengan strategi baru yang lebih menarik dan mengesankan bagi anak seperti halnya dengan melalui kegiatan kartu angka. Penelitian ini menggunakan pendekatan kuantitatif, dengan subjek penelitian anak autism yang sesuai kriteria dalam penelitian ini. Anak autism yang memenuhi kriteria akan dijadikan sebagai sampel penelitian. Sampel penelitian ini sebanyak 38 anak, dengan Teknik analisis data menggunakan analisis regresi linear sederhana. Media Kartu Angka (Flash Card) Berpengaruh Terhadap Peningkatan Pemahaman Konsep Bilangan Pada Anak Autism dengan nilai R square (R2) 0,839 yang dapat diartikan 83,9% Media Kartu Angka (Flash Card) Berpengaruh Terhadap Peningkatan Pemahaman Konsep Bilangan Pada Anak Autism. Sedangkan 17,1% dipengaruhi oleh faktor-faktor lainnya yang tidak dibahas pada penelitian ini.
Pengimplementasian Model Discovery Learning pada Pembelajaran PKn di SD
Authors: Kartini Dewi , Sabilla Annisa , Wulandari Dwi , Dewi Dinie Anggraeni , Furmasari Yayang Furi
Published: March 2022

Pendidikan Kewarganegaraan (PKn) adalah pendidikan yang sangat penting di SD karena perannya sebagai pembentuk karakter kebangsaan. Oleh karenanya, mata pelajaran PKn membutuhkan efektivitas dalam penyelenggaraannya. Maka dipilihlah model pembelajaran yang sesuai dengan tuntutan dan perkembangan zaman  yakni model pembelajaran discovery learning. Penelitian ini dimaksudkan untuk mengetahui bagaimanakah implementasi serta efektivitas model pembelajaran discovery learning pada pembelajaran PKn di SD Labschool UPI Cibiru dan SDN Percobaan Cibiru. Metode penelitian pada penelitian ini adalah metode kualitatif deskriptif yaitu metode penelitian yang digunakan untuk memahami makna dari permasalahan sosial dan kemanusiaan. Hasil penelitian menunjukkan bahwa efektivitas model pembelajaran discovery learning mencapai persentase sebesar 80% dan dianggap efektif karena telah mencapai persentase lebih dari 50%. Hasil ini diperoleh dari dua sekolah sebagai objek penelitian yaitu, SD Lab School UPI Cibiru dan SDN Percobaan. Implikasi dari model pembelajaran ini adalah siswa secara mandiri mampu menemukan konsep pengetahuan kebangsaan sehingga mampu menerapkannya dalam berperilaku dan bersikap.
An investigation into the waste segregation behavior of the households in the city of Bhubaneswar, Odisha
Authors: Rath Swatiprava , swain Pranaya
Published: March 2022

Municipal solid waste constitutes a major portion of
the total city waste produced in India. Very often this is ignored while considering
waste problems in the cities. The cities are now having enormous environmental
problems due to municipal solid waste. The segregation of waste is essential to
implement Reduce, Reuse and Recycle. It has been an unsustainable and
uneconomical practice to not segregate waste at the source. The paper explains
the waste segregation activities of the householders of the city of Bhubaneswar, Odisha, India and the social and environmental outcomes of such behavior. The paper is based
on both primary and secondary sources of data.
The Role of Communication in Enhancing Institutional Effectiveness: A Case Study of the University of Trinidad and Tobago
Authors: Sooknanan Prahalad
Published: March 2022

The findings conclude that respondents strongly agree with
the importance of communication (82.4%)., the role of formal communication
compared to informal communication (71.3%), the belief that face-to-face communication
is more effective than electronic communication (52.7%), personal competence as
communicators (85.9%), but mixed response regarding communication and
institutional effectiveness. Overall, the findings answered the RQ and
generated five statistically-supported recommendations for better transparency
and accountability (77.8%), improved feedback from administration (74.2%),
quicker official updates (66.2%), clear reporting structures (55.6%), and
increased inter-campus communication (50%) to enhance communication for
institutional effectiveness.
Numerical Construction of Lyapunov Functions Using Homotopy Continuation Method
Authors: IBRAHİM Alhassan , I BALA Saminu , AHMED Idris , IBRAHİM Muhammad Jamilu , JARAD Fahd
Published: March 2022

Lyapunov functions are frequently used for investigating the stability of linear and nonlinear dynamical systems. Though there is no general method of constructing these functions, many authors use polynomials in $ p-forms $ as candidates in constructing Lyapunov functions while others restrict the construction to quadratic forms. By focussing on the positive and negative definiteness of the Lyapunov candidate and the Hessian of its derivative, and using the sum of square decomposition, we developed a method for constructing polynomial Lyapunov functions that are not necessarily in a form. The idea of Newton polytope was used to transform the problem into a system of algebraic equations that were solved using the polynomial homotopy continuation method. Our method can produce several possibilities of Lyapunov functions for a given candidate. The sample test conducted demonstrates that the method developed is promising
Resume Ekonomi Mikro
Authors: MUKARRAMA RIFQATUL
Published: March 2022

Resume Ekonomi Mikro
Makalah Pengertian Koperasi, Koperasi Syariah dan UMKM
Authors: K Khelvin.
Published: March 2022

Salah satu lembaga yang mampu menjadi solusi untuk para pelaku usaha yaitu koperasi syariah. Koperasi syariah mampu memberikan modal kepada pelaku usaha yang membutuhkan modal usaha. Diberikannya suatu modal dengan syarat jenis usahanya tidak menantang ajaran Islam. Koperasi syariah mampu meningkatkan kesejahteraan pada masyarakat yang menjalankan bisnis atau usahanya. Jika usahanya memiliki modal yang cukup maka pelaku binis tersebut mampu mengembangkan usahanya. Koperasi syariah juga dapat meningkatkan roda perekonomian suatu negara.
hospitalitas kristen dalam psikologi lintas budaya
Authors: kendek yustika
Published: March 2022

Hospitalitas merupakan nilai penting yang dijunjung tinggi,dalam kehidupan para pengembala (nomaden) terdapat beberapa tempat umum dimana orang dapat menginap dan memperoleh makanan,praktik hospitalitas penting demi kelangsungan hidup,di satu pihak,para pengembara tergantung pada tuan rumah .konsep kuno mengenai hospitalitas ini masih lazim dibanyak kebudayaan saat ini. Hospitalitas dijunjung tinggi diberbagai belahan dunia,tetapi terutama kurangnya sumber-sumber membuat ketetapan mengenai hospitalitas sungguh diperlukan.budaya dapat membantu menjelaskan kemunculan perilaku abnormal pada manusia,oleh karena itu penting bagi kita untuk mempelajari psikologi Lintas Budaya.kristen suatu keyakinan yang dimiliki pada setiap orang dan suatu kepercayaa kepada Tuhan yang maha esa.psikologi budaya adalah studi komparatif dan kritis mengenai pengaruh-pengaruh budaya pada psikologi manusia
Attending to moving objects
Authors: Holcombe Alex O.
Published: March 2022

This book, posted with chapter hyperlinks, cross-references, and embedded movies at tracking.whatanimalssee.com, reviews some of what we know about multiple object tracking by humans. A revised version will appear in the Cambridge Element book series of Cambridge University Press.
Open and reproducible science practices in psychoneuroendocrinology: opportunities to foster scientific progress
Authors: Meier Maria , Lonsdorf Tina B , Lupien Sonia , Stalder Tobias , Laufer Sebastian Tristan , Sicorello Maurizio , Linz Roman , Puhlmann Lara
Published: March 2022

This perspective article was written by invitation of the editors in chief as a summary and extension of the symposium entitled Psychoneuroendocrine Research in the Era of the Replication Crisis which was held at the virtual meeting of the International Society of Psychoneuroendocrinology 2021. It highlights the opportunities presented by the application of open and reproducible scientific practices in psychoneuroendocrinology (PNE), an interdisciplinary field at the intersection of psychology, endocrinology, immunology, neurology, and psychiatry. It conveys an introduction to the topics preregistration, registered reports, quantifying the impact of equally-well justifiable analysis decisions, and open data and scripts, while emphasizing ‘selfish’ reasons to adopt such practices as individual researcher. Complementary to the call for adoption of open science practices, we highlight the need for methodological best practice guidelines in the field of PNE, which could further contribute to enhancing replicability of results. We propose concrete steps for future actions and provide links to additional resources for those interested in adopting open and reproducible science practices in future studies.