bluuebunny/crossref_metadata_2025 huggingface dataset:
Examination of the Effectiveness of Local Therapy for Oligo-recurrence of Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer
Authors: Sonoda Dai , Kondo Yasuto , Maruyama Raito , Hayashi Shoko , Naito Masahito , Mikubo Masashi , Matsui Yoshio , Shiomi Kazu , Satoh Yukitoshi
Published: September 2022

Purpose
The effectiveness of local therapy was recently reported in patients with non-small cell lung cancer (NSCLC) oligo-recurrence, a metachronous recurrence with a limited number of recurrences. Conversely, systemic therapy for NSCLC has made remarkable progress with the advent of molecular targeted therapy. In particular, epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) arevery effective in the treatment of EGFR-mutated NSCLC. This study aimed to evaluate the effectiveness of radical local therapy for oligo-recurrence in EGFR-mutated NSCLC.
Methods
Between 2004 and 2014, 811 patients underwent complete resection for NSCLC at Kitasato University Hospital, and 244 of these patients developed recurrence. Oligo-recurrence was defined as the presence of two or fewer recurrent lesions, and 34 patients presented with EGFR-mutated oligo-recurrence. We retrospectively examined and compared the effects of EGFR-TKIs with those of radical local therapy in patients with oligo-recurrent EGFR-mutated NSCLC.
Results
The five-year post-recurrence survival (PRS) rates of patients with EGFR-mutated oligo-recurrence who received radical local therapy (n = 23) and those who did not (n = 11) were 59.4% and 45.5%, respectively (P = 0.777). Multivariate analysis revealed no favorable prognostic factors associated with prolonged PRS, and radical local therapies did not improve PRS in patients with oligo-recurrence (P = 0.551).
Conclusion
Radical local therapy did not affect PRS in patients with oligo-recurrent EGFR-mutated NSCLC. Thus, even in cases of oligo-recurrence, the administration of local therapy in patients with EGFR-mutated NSCLC must be carefully considered.
Sonochemistry in organic synthesis: A convenient method for the preparation of halo-bicyclic molecules with keten addition reaction and biological properties of Dimethyl 7,7-dichloro-8-oxabicyclo[4.2.0]oct-3-ene-3,4- dicarboxylate
Authors: Sezen Hazal , Kuş Nermin Şimşek , Özdemir Sadin , Tollu Gülşah
Published: September 2022

A convenient method for the preparation of halo-bicyclic molecules likely to show biological activity, from keten addition reaction with dimethyl cyclohexa-1,4-diene-1,2-dicarboxylate (3) and dichloroketene, respectively, under ultrasound irradiation, is reported. First, 1,4-diene 3 had been synthesized with Diels-Alder addition, and then the ketene addition reaction was carried out. Ultrasonic and non-ultrasonic conditions in the ketene addition reaction were investigated. Then, lactones (8 and 9) were obtained from ketene adducts. The structures of the molecules were illuminated by IR, and NMR spectroscopy techniques, especially Cosy spectroscopy. The test compounds improved antioxidant ability from 9.48% to 69.29% at concentration rates of 12.5-200 mg/L. The newly synthesized dichloro lactone 8 showed good antibacterial activity against gram-negative and –positive bacteria and also, antifungal activity. The antibiofilm activity of dichloro lactone 8 investigated and it showed 99.92 and 99.14% biofilm inhibiton activity againts Staphylococcus aureus and Pseudomonas aeruginosa, respectively at concentration of 250 mg/L. Moreover, it was displayed 100% Escherichia coli viability inhibition at concentrations of 125 and 250 mg/L.
ncRNAs-mediated TIMELESS overexpression in lung adenocarcinoma correlates with reduced tumor immune cell infiltration and poor prognosis
Authors: Gao Xinliang , Tang Mingbo , Tian Suyan , Li Jialin , Liu Wei , Hua Shucheng , Wei Shixiong
Published: September 2022

Background
Lung adenocarcinoma (LUAD) has a poor prognosis. Circadian genes such as TIMELESS have been associated with several pathologies, including cancer. The expression of TIMELESS and the relationship between TIMELESS, infiltration of tumors and prognosis in LUAD requires further investigation.
Methods
In this study, we investigated the expression of TIMELESS and its association with survival across several types of human cancer using data from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression Program. Noncoding RNAs (ncRNAs) regulating overexpression of TIMELESS in LUAD were explored with expression, correlation, and survival analyses. Immune cell infiltration and biomarkers were analyzed between different TIMELESS expression levels. The relationship between TIMELESS expression and immunophenoscores, which were used to predict response to immunotherapy, was evaluated.
Results
TIMELESS was identified as a potential oncogene in LUAD. NcRNA analysis showed MIR4435-2HG/hsa-miR-1-3p may interact with TIMELESS in a competitive endogenous RNA network in LUAD tumor tissues. Most immune cells were significantly decreased in TCGA LUAD tumor tissues with high TIMELESS expression except for CD4 + T cells and Th2 cells. TIMELESS expression in LUAD tumor tissues was significantly negatively correlated with neutrophil biomarkers, dendritic cell biomarkers (HLA-DPB1, HLA-DQB1, HLA-DRA, HLA-DPA1, CD1C) and an immunophenoscore that predicted outcomes associated with the use of immune checkpoint inhibitors.
Conclusions
These findings imply that ncRNAs-mediated TIMELESS overexpression in LUAD tumor tissues correlated with poor prognosis, reduced immune cell infiltration in the tumor microenvironment, and poor response to immune checkpoint inhibitors.
Shared rules between planetary orbits displayed by multi-planet systems and their function
Authors: Ma Yong , Wen Xiumei
Published: September 2022

To better understand orbital relationships, we calculated the exoplanetary observation data of all multi-planet systems with the method of orbital ratio parameter analysis. The calculations display the orbital relationships between all exoplanets of each multi-planet system in a clearer quantification way, including the exoplanets of mean motion resonances (MMRs). By statistics and comparisons, we found more orbital features beyond MMRs and summarized them into the shared rules between planetary orbits. Meanwhile, we derived corresponding equations and principles, based on which we classified the 96 four-and-more-planet extrasolar systems observed. According to Criterion (N-B), 83 are the systems with the shared rules. By analysis, we proposed migratory and absent exoplanets, and calculated their orbits. We also summed up the main reasons why exoplanets migrate or are absent, which cause large deviation rates. The discovery of the shared rules provides a different way to study the completeness and evolution of multi-planet systems.
Neutrophil to lymphocyte ratio as a recurrence predictive marker in non-muscle invasive Bladder Cancer: A retrospective cohort study
Authors: Jelleli Nejmeddine , Sakly Aymen , Zakhama Walid , Chouaya Ines , Jelleli Bilel , Chouaya Sabrine , Jemaa Mohamed Ben , Sidhom Wael , Bedoui Youssef , Tabka Helmi , Binous Mohamed Yassine
Published: September 2022

Background: Recurrence is a main risk of non-muscle invasive bladder cancer (NMIBC). It depends on cystsoscopic and anatomopathologic factors. The outlook of current researches is to identify non-invasive prognostic factors and enhance the predictive value of existing prognostic patterns. Neutrophil to lymphocyte ratio (NLR) is a biological marker, which has demonstrated its prognostic role in several solid tumors. This study aimed to explore the interest of NLR in predicting the recurrence risk of NMIBC.
Materials and Methods: This is a retrospective study of 166 patients treated for NMIBC. Demographic characteristics, clinical data, biological parameters, cystoscopic findings, pathological data and follow-up results were collected. NLR was calculated preoperatively. We adopted the cut-off value 2.5 for the NLR. Multivariate analysis and ROC curve were used to assess different correlations. The study of survival was carried out by Kaplan-Meier estimator. SPSS version 26 was used for analyzing the data. P value ≤ 0.05 was considered statistically significant.
Results: The male to female ratio was 14.09. The mean age was 65.99 (standard deviation (SD) = 12.431). The mean of NLR was 2.17 (SD= 0.78). Sixty-three 63 patients (38%) had high NLR. Urothelial bladder disease follow-up revealed tumor recurrence in 87 patients (52.41%). In multivariate analysis, NLR was significantly associated with NMIBC recurrence (p=0.025). According to ROC curve, area under the curve was 72.7 % attesting the performance of this marker in BC predicting recurrence. Kaplan-Meier curves showed that a higher preoperative NLR is significantly associated with high decreased recurrence-free survival (p=0.002).
Conclusions: NLR is a hematological inflammation parameter that has shown interesting prognostic properties in NMIBC. It could be used as a valuable marker allowing urologist identifying patients most likely to have recurrence of their BC. Nevertheless, prospective randomized studies are necessary for the validation of our results.
A local physical explanation of why we never see an electron at both slits of a double-slit experiment at the same time
Authors: Ramakrishna Satish
Published: September 2022

In the standard double-slit experiment, the interaction between the electron and a detector at either of the slits is supposed to be local. However, one never notices a situation
where the electron is detected at both slits simultaneously in the frame of the observer. This is usually explained by the statement that there is only one electron that is
being located and it obviously cannot actually be located in two places at the same time in the observer's frame of reference. However, this is a global constraint, which is hard to understand when the interaction between the electron and a measurement device at a particular slit is completely local - how would the measuring device realize that there was only one electron that was to be detected? It would be useful to deduce this from purely local interactions at each slit, even with detectors at each slit, without having to adduce assumptions about long-range correlations between (potentially) space-like separated events.
In this paper, we start with a Hamiltonian that was studied in a previous paper on the measurement problem, with a local interaction between the electron and a detector -
here we assume that there is a detector at each slit. We study this problem numerically and also make a theoretical argument that the detection problem is exactly the same as that of the
problem of equilibration of a macroscopic number of coupled harmonic oscillators. At each detector, as the measurement happens, the amplitude for each of the states of the measuring apparata relaxes to an equilibrium configuration akin to the equilibration of a thermodynamic system.
The problem of the detection of the electron at each slit is then mapped to the motion of a random walker in a line with reflecting barriers at both ends, where the ends are separated by a macroscopic number of steps.
This connection to a well-studied mathematical problem has a well-understood consequence - two (or a finite number of) random walkers in this space will be expected to be separated by a macroscopic number of steps. Hence, only one of the detectors will see a macroscopic number of its
detection degrees of freedom affected - {\it ergo,} only one of the detectors, selected completely at random, will "see" the electron. For a large, macroscopic, though finite-sized measurement device, there will be a vanishingly small chance of detecting the electron simultaneously at both slits. Indeed, in the limit of an infinitely massive detector, we will never detect the electron at two places at the same time.
This problem also illustrates further that the systematic application of Schrödinger's equation along with a local interaction Hamiltonian that
effectively represents the measurement process helps solve some curious
issues in the quantum measurement problem straightforwardly.
Application of Immunocytochemistry to Monitor the T Cell Subset Counts in Patients with Sepsis
Authors: Deng Ronghua , Deng Lan , Tian Yamin , Deng Guopeng , Zeng Jiannan , Li Zhuo , Lin Xiaolong , Zhong Yaoqu , Chen Weisheng
Published: September 2022

[Objective]: To evaluate the application significance of immunocytochemistry for monitoring peripheral blood CD3+ T cell subset (CD3+/CD3+CD4+/CD3+CD8+) counts in patients with sepsis.
[Methodology]: 138 patients with sepsis, along with 20 healthy subjects for control purposes, were chosen for the research. On the first day of admission (D1), three peripheral blood samples from 20 healthy subjects and 20 patients with sepsis were collected for lymphocyte counts by routine blood tests and T cell subset counts by immunocytochemistry and flow cytometry. The remaining 118 patients with sepsis were asked to give two peripheral blood samples on the first day of admission and 20 of them were additionally required to give the peripheral blood samples on the fourth day of admission (D4), for lymphocyte counts by routine blood tests and T cell subset counts by immunocytochemistry. This was in order to analyze and compare the count levels of the lymphocyte and CD3+T cell subsets between the sepsis group and the healthy control group, and to explore the correlation and difference of CD3+ T cell subset counts obtained by flow cytometry and immunocytochemistry.
[Results]: Lymphocyte counts by routine blood tests and CD3+T cell subset counts of the patients with sepsis were significantly lower than those in the healthy control group (P<0.01). The CD3+T cell subset counts of the surviving group of D4 increased significantly compared with D1, while the non-surviving group did not rebound significantly. Meanwhile, there was a significantly positive correlation between lymphocyte counts by routine blood tests and CD3+T lymphocyte subset counts in patients with sepsis and the healthy control subjects, with no significant difference between the two by t-test P <0.01).
[Conclusion]: Detection of CD3+ T cell subsets counts by the immunocytochemistry method can reflect the cellular immune status of patients at the time, thus it can be used as one of the immune monitoring methods in patients with sepsis.
A Study to Derive the Expected Loss of Real Estate Project Financing by Banks through Information Memorandum
Authors:   Korea Urban & Real Estate Association, Lee Seong-Sil , Lim Mi-Hwa
Published: September 2022

Accordingly, this study analyzed the relationship between the EL amount and various real estate PF factors based on the current status of real estate PF handling by A Bank from 2015 to 2020. Comparing with previous studies that simply analyzed delinquency, provision rate, and loan quality-oriented analysis, or only negative loans without distinction from approved loans, this study selected and analyzed the EL amount, which is considered more in terms of risk management, together with the implementation of Basel III. It was analyzed by selecting it as a variable. Even if the loan was executed after the loan term and repayment method were confirmed at the time of the loan agreement, it was confirmed that the term and repayment method are not risk variables because early loan repayment is made through income from pre-sale. In addition, it was confirmed that PF, which is a special finance sector other than general corporate finance, is considering acquiring collateral for stable receivables bond collection.
Increasing the productivity of manufacturing firms in Cameroon in a sustainable way: Renewable or non-renewable energy?
Authors: Anya Saturnin Bertrand Nguenda , Landry Etienne Koumou
Published: September 2022

The question of what energy form should guarantee firm productivity in the future is becoming increasingly important, considering the risk that the gradual depletion of the world’s non-renewable energy reserves poses to the continuity of productivity. This study aims to assess the effect of individual energy forms on productivity growth of manufacturing firms in Cameroon. This paper uses a two-stage stochastic frontier method to determine the energy form that is most likely to ensure the continuity of the productivity of manufacturing firms in Cameroon in the next few years. The data for the study came from the Annual Enterprise Surveys (EAE) conducted by the National Institute of Statistics of Cameroon (NIS) from 2012 to 2019. The analysis data constitute a panel of 288 representative firms. Factors that primarily explain firm productivity were value-added, renewable and non-renewable energy, capital, labor, and raw materials. The study analyzed the entire manufacturing industry, agri-food sector, and other manufacturing industries. Despite being a group estimate, individual firms are taken into account. Across the manufacturing industry in Cameroon, the results indicate that renewable energy is the most advantageous form. Indeed, this form would cause a 9.27% increase in productivity for a one percentage point increase. However, as the impact coefficients are insignificant, it is difficult to assess the contribution of non-renewable energy to firm productivity.
Acknowledgments The authors would like to sincerely thank Atanase Yene for his invaluable support in this work, helpful comments, and suggestions on the previous draft of this paper. The usual disclaimer applies, and views are the authors’ sole responsibility.
The Covid-19 pandemic and livelihood vulnerabilities of people in urban areas of Vietnam
Authors: Thuy Cu Thanh , Anh Nguyen Tuan
Published: September 2022

This study was carried out to examine the livelihood vulnerabilities encountered by residents in Vietnam’s urban areas during the emergence of the Covid-19 pandemic. People’s vulnerabilities are approached in terms of employment and income vulnerabilities. The study compares the changes in income and employment of residents in Vietnam’s urban regions during the outbreak of Covid-19 and after the epidemic which is gradually controlled to determine the livelihood losses that people in urban areas face. Data for the study were collected from 206 families in Vietnam’s urban areas that were directly affected by the epidemic. The multivariate regression method is used to evaluate people’s vulnerability during epidemic outbreaks. According to the findings of the study, the income disparity between the outbreak of the Covid-19 pandemic and the end of the epidemic is fairly considerable (about VND 7.6189 million/month). The multivariate regression model’s results reveal that the degree of government assistance provided during the epidemic time has the greatest positive impact on people’s income and quality of life (Standardized Coefficients = 0.584), whereas people’s unemployment during the pandemic outbreak period has a negative impact, causing damage to people’s income (Standardized Coefficients = –0.395). The study will recommend new livelihood strategies for residents in the context of Vietnam’s “new normal” based on the findings of the investigation.
The interplay between technological innovation, energy efficiency, and economic growth: Evidence from 30 European countries
Authors: Koilo Viktoriia , Honningdal Grytten Ola , Emblemsvag Jan
Published: September 2022

It is assumed that technological progress plays a vital role in energy efficiency improvements when the effects of industrial restructuring, infrastructure, environmental challenges, and economic shocks seem more dubious. However, a limited number of studies have been conducted to examine the impact of technological innovation on countries’ energy efficiency levels. This study aims to explore the relationship between energy efficiency, technological innovation, and economic growth in 30 European countries by utilizing data from 2012 to 2020. To this end, a two-stage analysis is carried out. The first step involves estimating the total factor energy efficiency (TFEE) by the countries to illustrate the effects of energy parameters on economic growth and the environment, and technological innovation (TI) to estimate the innovation capability of each country by using data envelopment analysis (DEA) methodology. The second step includes a panel regression model to explore how technological innovation affects energy efficiency, considering the degree of government intervention, industrial structure, infrastructure, and economic openness.The results indicate that the bottom-15 countries, whose TFEE scores were the lowest, are mainly countries of Central and Eastern Europe. Regarding the countries’ technological capability, the results were similar, but the score was lower than the TFEE. Moreover, the regression analysis shows that a one percent increase in innovation activity contributes to an increase in energy efficiency by 0.27 percent. Hence, it confirms the notion of a positive impact of new technology on energy efficiency.
AcknowledgmentsThe study is supported by the grant from the Research Based Innovation “SFI Marine Operation in Virtual Environment (SFI-MOVE)” (Project No. 237929) in Norway.
The Influence of the Digital Economy and Women's Empowerment on the Family Economy
Authors: Dharmayanti Nela , Fatkar Budiastuti , Ratnasari Aisyah
Published: September 2022

This study aims to ascertain the effect of the digital economy and women's empowerment on the family economy. SMEs communities in Tangerang City, Banten Province, were included in this study. The sampling technique utilized is a combination of probability sampling and random sampling. They are compiling data through the use of a questionnaire. The maximum number of people whose data can be analyzed is 97. This study used Partial Least Squares to analyze the data (PLS). The findings indicated that (1) the construct of the digital economy had a positive and significant effect on women's empowerment, with a statistical T value of 2.990; (2) the construct of women's empowerment had a positive and significant effect on the family economy, with a statistical T value of 7.141; and (3) both the digital economy and women's empowerment had a positive and significant effect on the family economy, with a statistical F value of 242.61.
Modeling of the influence of the wear of the cutting wedge of the tool on the stability of the metal turning process
Authors: Lapshin Victor P.
Published: September 2022

metalworking today, the assessment of the degree of wear of the cutting wedge of the tool during its operation is an extremely relevant and in-demand task. Even though a large number of methods for monitoring tool life have been developed, there are no unambiguous mathematical dependencies that determine the degree of wear of the cutting wedge according to indirectly measured data. The article proposes a new mathematical apparatus that has not been used before, which makes it possible to adequately interpolate vibrations and temperature in the contact zone into tool wear. The study aim of the study is to develop a method for indirectly estimating the wear rate of the tool, based on a consistent model of intersystem communication describing the force, thermal, and vibration reactions of the cutting process to the shaping movements of the tool. The study consists of experiments on a measuring stand and numerical modeling of the obtained data in Matlab with a comparative evaluation of them with the results of modeling of the mathematical apparatus proposed in the article. The results show that the mathematical model proposed in the article is applicable for an adequate interpretation of experimental data.
Numerical study on bored Pile-Soil interaction by specified constitutive model in coastal engineering (design)
Authors: Xie Qi
Published: September 2022

In Geo-engineering design, Geotech-engineers usually adopt ‘Mohr-Coulomb model (M-C)’ to substitute most soil material, this model is considered as linear elastic and perfectly plastic model, despite, in the coastal engineering, the sand-clay mixed with water, cement, fine aggregate or similar materials are the most common interface medium among soil and pile bodies, the frictions from them have strong affection on piles settlements, due to their complex components and mechanics, never can simulate these interface medium by ‘M-C model’ easily, hereby, the novelty of this article is that author adopt ‘Hardening soil constitutive model (HSs)’ as the interface medium and deployed numerical studies on its application in practical case, the studies included simulating the mechanic behaviors among soil and piles(morphology of deformation), design assumptions based on the analysis of geotechnic report and empirical views, besides compared the pile settlement curves by ‘M-C’ and ‘HSs’ models with the static loads test results, and identified the ‘HSs’ model is a suitable constitutive model for sand-clay mixture soil in this Geo project design. In the end, author proposed a few conclusions about the medium birth mechanism, criteria of model selection and advice for similar engineering reference.
Desarrollo urbano y estratificación social como predictores de hacinamiento y acceso a internet en la vivienda
Authors: Hernández Ponce Luis Enrique , González R. Marino J.
Published: September 2022

El objetivo del trabajo consistió en demostrar que las condiciones urbanas predicen variaciones en hacinamiento y equipamiento telemático en la vivienda venezolana. A partir de la Encuesta de Condiciones de Vida de 2014 y 2017 se construyeron dos modelos de análisis de senderos, en los que las condiciones urbanas, el tamaño de ciudad y la estratificación social fueron las variables exógenas, las condiciones de la vivienda fue la variable mediadora y el equipamiento telemático y el hacinamiento fueron las variables de resultado. La variable predictora de mayor peso fue condiciones urbanas, seguida por estratificación social, mientras tamaño de ciudad tuvo poca influencia. La comparación de los efectos directos e indirectos sobre las variables de resultado destacó la importancia del desarrollo urbano como sustento de la vivienda. Los datos disponibles para la construcción de los modelos se restringieron a 2014 y 2017, umbral de la crisis humanitaria sufrida por el país. Mejores condiciones urbanas predicen disminuciones del hacinamiento e incrementos del equipamiento telemático y acceso a internet, con condiciones de la vivienda como variable mediadora. Las políticas sociales deben priorizar la inversión en mejoras urbanas antes que la construcción masiva de viviendas. El trabajo es una contribución a la comprensión de la política social habitacional desde el enfoque del multiplismo crítico propuesto por W. N. Dunn.
transición teórica a la democracia
Authors: Vázquez Almanza Paola Patricia
Published: September 2022

En este artículo se analiza la transformación de la sociología y la ciencia política en México ligadas a la adopción del paradigma democrático. Para ello, se refieren dos conjuntos de fenómenos. El primero abarca: 1) el contexto del cambio internacional de las ciencias sociales, y 2) los cambios de la politología norteamericana. El segundo explora: 1) la historia de la sociología y la ciencia políticas mexicanas y su nexo con el Estado; 2) la frontera entre espacio público y academia, y 3) la operacionalización del paradigma democrático. Los resultados muestran la existencia de un desequilibrio normativo y conceptual que persiste en las interpretaciones de la realidad política. Desde su naturaleza conceptual, este artículo ofrece una útil reflexión metateórica que evidencia la necesidad de debatir las paradojas de la teoría democrática.
haciendas del norte del Valle del Mezquital y su vínculo con el real de minas de Zimapán en la época novohispana
Authors: Bello Nuñez Silvia Lorena
Published: September 2022

El artículo tiene como objetivo evidenciar el vínculo económico que establecieron las haciendas del norte del Valle del Mezquital con el real de minas de Zimapán durante la época virreinal, con la intención de visibilizar el papel de estas unidades productivas en la extracción de plata novohispana. Los datos se construyeron principalmente de la sistematización de fuentes secundarias y de impresos de la época, así como, en menor medida, de documentos de archivo, cartografía histórica y trabajo de campo. Estos fueron analizados desde su dimensión espacial por medio de los sistemas de información geográfica. Los resultados conducen a reconocer que las haciendas ayudaron a la dinámica de producción argentífera de Zimapán, gracias a que proveyeron al centro minero de los insumos necesarios para la realización de dicha actividad, así como a la integración económica y social del Mezquital. De igual forma, los ricos mineros conformaron una élite regional al acaparar tierras, recursos naturales y fuerza de trabajo local para abaratar los costos de producción, además de construir una importante red de caminos para agilizar el flujo de mercancías.
Clinical Consideration for Mesenchymal Stem Cells in Treatment of COVID-19
Authors: Wu Kang-Hsi , Chao Yu-Hua , Weng Te-Fu , Li Ju-Pi
Published: September 2022

COVID-19, which has strongly affected the 21st century, is caused by severe acute respiratory syndrome
(SARS)-CoV-2. The emergence of viral variants has rendered even vaccinated people prone to infection;
thus, completely eradicating COVID-19 may be impossible. COVID-19 causes hyperinflammation, leading to
organ damage and even death. SARS-CoV-2 infects not only the lungs, causing acute respiratory distress syndrome,
but also the extrapulmonary organs. Not all patients with COVID-19 respond adequately to treatments
with antiviral and anti-inflammatory drugs. Therefore, new treatments are urgently needed. Mesenchymal stem
cells (MSCs) exhibit immunomodulatory activity and are used to safely and effectively treat various immune
disorders. Evidence has indicated the efficacy of MSCs against COVID-19. However, the safety and efficacy of
MSCs must be probed further. For this reason, we explored key clinical challenges associated with MSC therapy
for COVID-19, such as sources, administration routes, cell dosage, treatment timepoint, and virus reactivation.
We identified several challenges that must be addressed before MSCs can be clinically applied.
Coexistence of Competing Opportunistic Pathogens in Critically ill Patients with Advanced AIDS: A Case Report and Literature Review
Authors: Voznesenskiy Seregey , Ermak Tatyana , Emerole Karl , Samotolkina Еlena , Klimkova Polina , Abramova Evgeniya , Kozhevnikova Galina
Published: September 2022

Introduction:

Opportunistic infections (OIs) are the leading causes of morbidity and mortality among HIV-infected individuals. The incidence of OIs is greater in antiretroviral treatment (ART) naive patients. As of 30 June 2021, 28.2 (73%) people with HIV/AIDS (PLWHA) were accessing antiretroviral therapy (ART) globally, leaving the remaining 27% PLWHA without ART at risk for OIs. Multiple opportunistic infections are caused due to the coexistence of competing opportunistic pathogens that confound clinical manifestations, investigative procedures, and management protocols.

Case Presentation:

In this report, we describe the case of a critically ill HIV female patient admitted to the ICU. The patient was diagnosed with multiple opportunistic infections and subsequently died after her illness progressed. Due to the paucity of information on the subject, we conducted a retrospective study of 1440 case records of HIV/AIDS critically ill patients to determine the incidence and spectrum of multiple opportunistic infections. We performed a review of the available medical literature relevant to the subject.

Conclusion:

Knowledge of such events would guide and enhance the physician's diagnostic and management strategies, especially in resource limited regions.
Recognizing Rice Leaves Disorders by Applying Deep Learning
Authors: Singh Taranjeet , Kumar Krishna , Bedi S. S. , Bhadwaj d Harshit
Published: September 2022

Rice is one of the staple crops in the world, as it is a rich source of protein,
minerals, fibre, and vitamins. It is cultivated almost in every part of the world, but its
productivity decreases due to several diseases. If these diseases are identified at the
initial stages, then preventive measures can be taken, but their symptoms are quite
similar for human eyes to recognize them correctly. Therefore, there is an immense
need to apply automated techniques for recognizing rice diseases. Various Artificial
Intelligence (AI) based prototypes have been surveyed in this chapter. These
techniques were proposed by researchers for diagnosing rice disease. Here, our main
goal is to present ideas on how Pretrained Neural Networks can be used in the
recognition of rice diseases. Therefore, a brief description of AI techniques and their
comparison is also outlined.
Superconductors for Magnetic Imaging Resonance Applications
Authors: Raza A.
Published: September 2022

Magnetic Resonance Imaging (MRI), a medical imaging technique is being widely used in diagnostic procedures. This technique is based on radiology and generates clear pictures of the anatomy and other physiological processes in the human body. A strong magnetic field is the key parameter for better resolution images provided it does not damage healthy tissues. The fundamental principle behind MRI is the response of the atomic nucleus against the magnetic field which is followed by the image creation based on the distribution of hydrogen nuclei in a specific organ under observation. Stronger magnetic fields produce improved images with higher resolutions, that is why several research groups around the globe are working to develop such MRI systems without putting harmful effects on the exposed organs.
relationship between the leadership behavioral factors and the work motivation to the teacher performance in SMK Negeri 3 Manado
Authors: Kalalo Rieneke R. , Kalangi Jola Silvana , Lumentah Lenda , Lintong Elsje
Published: September 2022

Teacher leadership in school is increasingly being demanded to be able to improve the quality of teachers. It is required to do the analysis of the leadership behaviors toward teacher performance, the relationship between work motivation and teacher performance as well as the relationship between Leadership Behavior and Work Motivation towards Teacher Performance. This research is based on a qualitative approach.  In this study, the research sample is all members of the population unit totaling 13 people. The data collected was using a questionnaire instrument. The collected data of the researchable variable was analyzed by using the correlation technique of Product Moment and Double Correlation. The result of the research states that there was a relationship between leadership behavior and teacher performance in SMK Negeri 3 Manado, which was furthermore found as the relationship between work motivation and teacher performance as well as the relationship between leadership behavior and work motivation aligned with the teacher performance. In sum, the leader must apply behavioral leadership that builds school organization and motivation for teacher performance in their work environment. The teacher's performance on motivation needs to get improved, encouraged, and facilitated so that it will increase the professional performance of the teachers.
Efficacy of Air Frying as a Hot Air Pre-treatment Technique in Enhancing the Yield of the Major Oil-derived Sinapic Acid Derivatives from Canola Oil
Authors:   Richardson Centre for Food Technology and Research, University of Manitoba, Fadairo Olamide , Nandasiri Ruchira ,   University of Manitoba, Eskin N.A. Michael ,   University of Manitoba, Scanlon Martin ,   University of Manitoba
Published: September 2022

Pre-treatment techniques such as dry heating by microwave roasting, conventional oven and air frying have been applied in the roasting of oil-seeds and their co-products prior to oil pressing to enhance canolol extraction. This research investigated the efficacy of air frying as hot air pre-heat treatment strategy for enhancing the extraction and recovery of oil-derived sinapic acid derivatives from canola oil. Air frying of canola seeds was conducted at temperature-time combinations of 160, 170, 180 and 190 oC for 5, 10, 15 and 20 minutes, respectively. Oil was extracted using the Soxtec method. Extraction of oil-soluble sinapic acid derivatives (SADs) was conducted using an equal volume of hexane and 70% (v/v) aqueous methanol and quantified by HPLC-DAD. The results showed a time- temperature association for the recovery of the predominant oil-derived SADs from canola seed oil. The highest yield of canolol- a major oil-derived SAD was obtained at 190 oC for 15 mins air frying condition while sinapine and other unidentified SADs (RT-6.4, RT-8.1, RT-22.9 and RT-27.5 mins) were found in trace amounts with highest yield varying for individual SAD at different roasting conditions. This new pre-processing approach would be beneficial to the canola seed processing industry in improving canolol yield and the generation of novel antioxidant phenolic compounds with potential application in food, cosmetics, and pharmaceutical industries
Argamassas de cimento com incorporação direta de Materiais de Mudança de Fase
Authors: Cunha S. , Aguiar J.
Published: September 2022

A eficiência energética dos edifícios é atualmente um dos principais objetivos da política energética a nível nacional e internacional. Os edifícios são um setor líder no consumo de energia, representando cerca de 40% do consumo de energia e emissões de CO2. A utilização de fontes de energia renováveis, tais como a energia solar, constitui um fator chave na redução da dependência energética dos edifícios. O armazenamento térmico conseguido através da utilização de materiais de mudança de fase (PCM) constitui uma estratégia para o desenvolvimento de edifícios com elevado desempenho térmico. Durante os últimos anos, vários estudos sobre materiais de construção com PCM encapsulado têm vindo a ser publicados. No entanto, a utilização de PCM não encapsulado é uma das principais lacunas do conhecimento. É importante notar que a utilização de PCM não encapsulado permite a utilização do material no seu estado puro, reduzindo os impactos ambientais e custo das soluções construtivas. O principal objetivo deste trabalho consistiu no estudo das propriedades físicas e mecânicas de argamassas com incorporação de PCM não-encapsulado, tendo sido possível concluir que a utilização de PCM nesta forma pode ser vista como uma solução económica e funcional para a melhoria da eficiência energética dos edifícios.
Спиновые и зарядовые флуктуации в твердых растворах замещения титана металлами группы железа
Authors: Повзнер А.А. , Волков А.Г. , Зайцева Н.А.
Published: September 2022

Рассмотрены возникающие при увеличении концентрации атомов замещения в твердых растворах титана с металлами группы железа топологические электронные переходы из омега- в альфа-фазу и из альфа- в бета-фазу. Получено, что вследствие различия потенциалов хаббардовского отталкивания титана и атомов замещения, а также температурных бозе-возбуждений, в топологической альфа-фазе усиливаются спиновые и зарядовые флуктуации электронной плотности. Учет флуктуаций позволяет описать концентрационное возрастание энтропии фаз, рассматриваемых титановых сплавов при различных температурах. Усиление электронных флуктуаций с увеличением температуры и концентрации, сдвигает химический потенциал за пределы топологической области электронного спектра, тем самым подавляя альфа-фазу и индуцируя электронный переход в бета-фазу. На примере расчетов энтропии сплавов замещения титана железом при различных температурах построена x-T диаграмма их структурных фаз, которая согласуется с имеющимися экспериментальными данными. Ключевые слова: твердые растворы, топологические электронные переходы, спиновые и зарядовые флуктуации, энтропия, структурные фазы.
Влияние внутригранульных мейсснеровских токов и захваченного в гранулах потока на эффективное поле в межгранульной среде и гистерезис магнитосопротивления гранулярного ВТСП
Authors: Балаев Д.А. , Семенов С.В. , Гохфельд Д.М.
Published: September 2022

The concept of an effective field in an intergranular medium is used to describe the hysteresis magnetoresistance of granular HTSCs. This effective field is a superposition of the external magnetic field and the field induced by the magnetic moments of the superconducting granules. The magnetic moment of the granules is contributed by the shielding currents and the trapped magnetic flux. We studied and analyzed the effect of the trapped flux on the magnetoresistance. It has been experimentally shown that the dependence of the residual resistance (after applying of the external field) on the trapped flux clearly correlates with the behavior of the remanent magnetization. In addition, special attention was paid to a detailed comparison of the magnetoresistance of the granular YBa2Cu3O7-delta for two cases: (a) the magnetization of HTSC granules is caused only by the trapped magnetic flux (in a zero external field) and (b) HTSC granules are in the Meissner state (the external field is smaller than the first critical field of the granules). It has been found that Abrikosov vortices and intragranular Meissner currents differently affect the effective field in the intergranular medium (for the same values ​​of magnetization for cases (a) and (b)). A possible reason for this difference is discussed.
Электронная зонная структура, распределение зарядовой плотности и химическая связь в молекулярных кристаллах халькогенов
Authors: Орлов В.Г. , Сергеев Г.С.
Published: September 2022

The electronic band structure and the charge density distribution are theoretically studied in rhombohedral and monoclinic selenium, rhombohedral and orthorhombic sulphur with the aim to classify types of chemical bonding in molecular crystals of chalcogens. It is found that valence s- and lower in energy p-electrons contribute mainly in covalent bonds between nearest neighboring atoms in ring-shaped molecules, while all types of valence p-electrons provide bonding between rings of atoms in crystals. Parameters of critical points and the character of the charge density distribution in their vicinity point to coexistence of a number of types of chemical bonding in molecular crystals of Se and S: covalent, semimetallic and one more type, characterizing by the charge density fluctuations. Van der Waals forces, being important for finding equilibrium lattice parameters, have little impact on the charge density distribution and on the chemical bonding in crystals of chalcogens.
Радиационно-стимулированный фазовый переход в суперионное состояние кристалла TlSe
Authors: Сардарлы Р.М. , Алиева Н.А. , Салманов Ф.Т. , Гахраманова С.М. , Мехтиева Р.Н. , Агаева Р.Ш.
Published: September 2022

Исследованы температурно-частотные зависимости: электрической проводимости (sigma(μ,T)), действительной и мнимой части комплексной диэлектрической проницаемости (ε'(ν,T)) и (ε''(ν,T)), комплексный импеданс соединения TlSe при воздействии различных доз гамма радиации. Исследован процесс возникновения концентрационной поляризации на границе ионный проводник блокирующий контакт. Установлен температурно-частотно-дозовый интервал возникновения ионной проводимости, импеданса Варбурга и обнаружен, радиационно стимулированный фазовый переход в суперионное состояние кристалла TlSe. Ключевые слова: комплексный импеданс, блокирующий контакт, ионной проводимости.
Динамика намагниченности одноосной наночастицы в области неколлинеарного ферромагнитного резонанса
Authors: Шутый А.М. , Семенцов Д.И.
Published: September 2022

Исследуется резонансная динамика магнитного момента одноосной элипсоидальной наночастицы при ее подмагничивании вдоль оси симметрии и возбуждении поперечным высокочастотным полем в случае параметров (частоты, подмагничивающего поля и параметра формы), отвечающих неколлинеарной ориентации равновесной намагниченности и внешнего статического поля. Выявлены частотные области, где при слабом переменном поле прецессия становится нелинейной и реализуются динамическая бистабильность, а также сложные пространственные аттракторы и хаос. Ключевые слова: эдипсоидальная наночастица, ферромагнитный резонанс, статическое и высокочастотное поле, нелинейность, эффективная анизотропия, бистабильность, регулярная и хаотическая прецессия.
Магнитодиэлектрический эффект в серии монокристаллов Pb-=SUB=-2-=/SUB=-Fe-=SUB=-2-x-=/SUB=-Mn-=SUB=-x-=/SUB=-Ge-=SUB=-2-=/SUB=-O-=SUB=-9-=/SUB=- (x=0-0.4)
Authors: Фрейдман А.Л. , Панкрац А.И. , Скоробогатов С.А. , Хороший И.Н. , Колков М.И.
Published: September 2022

In this work, the magnetodielectric response have been studied in a series of single crystals of Fe2-xMnxGe2Pb2O9 with substitution x from 0 to 0.43. The research results showed that an increase in x leads to a change in the orientation of the antiferromagnetism vector in a zero magnetic field. The application of an external magnetic field leads to spin-flop and spin-reorientation magnetic transitions, which are accompanied by anomalies in the behavior of the permittivity.When Fe3+ ions are replaced by Mn3+ ions, the response of the magnetic subsystem to an external magnetic field changes, which is naturally reflected in the change in the magnetodielectric response.
The permittivity changes stepwise when the magnetic subsystem passes into a state with a nonzero vector of the weakly ferromagnetic moment, or when its magnitude and orientation change due to a spin-flop transition. The latter indicates that a sharp change in polarizability is a consequence of a change in the contribution of the exchange energy, as well as the contribution of the Dzyaloshinskii-Moriya term, due to a change in the skew angle between two interacting magnetic moments.
Построение приближенного решения для разбавленного магнетика на основе решения для чистого магнетика на той же решетке
Authors: Сёмкин С.В. , Смагин В.П.
Published: September 2022

The paper proposes a method for approximate calculation of the magnetization of a dilute Ising magnet on a certain lattice, based on the use of an exact or approximate solution for a pure Ising magnet on the same lattice. Using the proposed method, it is possible to calculate the dependence of magnetization on temperature and concentration of non-magnetic impurities and the Curie temperature as a function of concentration for a diluted magnet. The proposed method is applied in the work to the solution in the mean field approximation, to the solution in the beta approximation, and to the exact solution on a square lattice.
Получение, особенности структуры, элементный состав и диэлектрические свойства двухслойной структуры на основе тонких пленок мультиферроика BiFeO-=SUB=-3-=/SUB=- и сегнетоэлектрика (Sr, Ba)Nb-=SUB=-2-=/SUB=-O-=SUB=-6-=/SUB=-
Authors: Павленко А.В. , Стрюков Д.В. , Кудрявцев Ю.А. , Матяш Я.Ю. , Маломыжева Н.В.
Published: September 2022

С использованием технологии прерывистого напыления на поверхности монокристаллической подложки MgO(001) изготовлены гетероструктуры BiFeO3/(Sr, Ba)Nb2O6. Проведены исследования структуры, профиля состава по толщине, морфологии поверхности и диэлектрических характеристик материалов. Установлено, что несмотря на формирование двух типов ориентационных доменов (±18.4o) в слое (Sr, Ba)Nb2O6, верхний слой BiFeO3 находится в соотношении полной параллельной ориентации с подложкой MgO(001). Показано, что состав пленок феррита висмута и ниобата бария-стронция по толщине пленки не изменяется, соответствует составам распыляемых керамических мишеней, признаков наличия буферных слоев не выявлено. Представлены результаты исследования диэлектрических и сегнетоэлектрических характеристик гетероструктуры. Обсуждаются причины выявленных закономерностей. Ключевые слова: тонкие пленки, гетероструктура, ниобат бария-стронция, феррит висмута.