bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of PM10 and PM2.5 and Their Metals Content in Different Typologies of Sites in South-Eastern Italy
Authors: Contini Daniele , Cesari Daniela , Donateo Antonio , Chirizzi Daniela , Belosi Franco
Published: June 2014

Samples of PM10 and PM2.5 were collected discontinuously between 2003 and 2010 at fifteen monitoring sites (urban, background, industrial) in the south-eastern part of Italy using a mobile laboratory. In total, 483 PM10 and 154 PM2.5 samples were collected and chemically analyzed for the determination of metal content. Data were used to investigate concentration differences among the typologies of sites, the seasonal patterns, and the influence of advection of Saharan dust (SD). PM10 and PM2.5 average concentrations increase from background to industrial and urban sites but the ratio PM2.5/PM10 is significantly lower (0.61 ± 0.10) in background sites. The average metals concentrations in PM10 and in PM2.5 do not show a clear dependence on site typology apart an increase in crustal elements in background sites and an increase in the enrichment factors of Ni and of Cr in PM10 in industrial sites. Urban sites show a statistically significant increase of PM10 average concentration during the cold seasons (autumn and winter), likely associated with the anthropogenic urban emissions, instead, the background sites show a decrease in concentrations during the cold seasons. This could be due to more frequent cases of SD observed in spring and summer periods that mainly influence background sites. The seasonal difference on the average concentration for industrial sites is not statistically significant. The SD cases influence both PM10 and PM2.5 concentrations but their effect is significantly larger on PM10. Over the studied area, the effect is relatively limited on long-term average PM10 (estimated increase of 3.2%) and PM2.5 (estimated increase of 1.5%) concentrations but it is significant on daily concentrations. It is estimated an increase of 22% of the probability to overcome the air quality standard daily threshold for PM10.
Capacity of Aromatic Compound Degradation by Bacteria from Amazon Dark Earth
Authors: Nakamura Fernanda , Germano Mariana , Tsai Siu
Published: June 2014

Amazon dark earth (ADE) is known for its high organic matter content, biochar concentration and microbial diversity. The biochar amount suggests the existence of microorganisms capable of degrading aromatic hydrocarbons (AHs). In an effort to investigate the influence of bacteria on the resilience and fertility of these soils, we enriched five ADE soils with naphthalene and phenanthrene, and biodegradation assays with phenanthrene and diesel oil were carried out, as well. After DNA extraction, amplification and sequencing of the 16S rRNA bacterial gene, we identified 148 isolates as the Proteobacteria, Firmicutes and Actinobacteria phyla comprising genera closely related to AHs biodegradation. We obtained 128 isolates that degrade diesel oil and 115 isolates that degrade phenanthrene. Some isolates were successful in degrading both substrates within 2 h. In conclusion, the obtained isolates from ADE have degrading aromatic compound activity, and perhaps, the biochar content has a high influence on this.
Development of a Digital and Battery-Free Smart Flowmeter
Authors: Hao Wang , Garcia Ronald
Published: June 2014

To effectively manage and save energy and natural resources, the measurement and monitoring of gas/fluid flows play extremely important roles. The objective of this study was to incorporate an efficient power generation and a power management system for a commercial water flow meter thus eliminating the usage of batteries. Three major technologies have made this possible: a low power consumption metering unit, a cog-resistance-free generator with high efficiency; and an effective methodology to extract/store energy. In this system, a new attempt and simple approach was developed to successfully extract a portion of the kinetic energy from the fluid/air, store it in a capacitor and used it efficiently. The resistance to the flow was negligible because of the very low power consumption as well as the application of the coreless generator technology. Feasibility was demonstrated through repeated experiments: for air flowing in an 11 mm diameter pipe, 18 s of energy harvesting at 10 revolution-per-second (RPS) turbine speeds generated enough power for the flowmeter to operate for 720 s with a flowrate of 20 RPS, without battery or any external power. The pipeline monitoring in remote areas such as deep sea oil drilling; geothermal power plants and even nuclear power plants could benefit greatly from this self-power metering system design.
Mapping Above- and Below-Ground Biomass Components in Subtropical Forests Using Small-Footprint LiDAR
Authors: Cao Lin , Coops Nicholas , Innes John , Dai Jinsong , She Guanghui
Published: June 2014

In order to better assess the spatial variability in subtropical forest biomass, the goal of our study was to use small-footprint, discrete-return Light Detection and Ranging (LiDAR) data to accurately estimate and map above- and below-ground biomass components of subtropical forests. Foliage, branch, trunk, root, above-ground and total biomass of 53 plots (30 × 30 m) were modeled using a range of LiDAR-derived metrics, with individual models built for each of the three dominant forest types using stepwise multi-regression analysis. A regular grid covered the entire study site with cell size 30 × 30 m corresponding to the same size of the plots; it was generated for mapping each biomass component. Overall, results indicate that biomass estimation was more accurate in coniferous forests, compared with the mixed and broadleaved plots. The coefficient of determination (R2) for individual models was significantly enhanced compared with an overall generic, or common, model. Using independent stand-level data from ground inventory, our results indicated that overall the model fit was significant for most of the biomass components, with relationships close to a 1:1 line, thereby indicating no significant bias. This research illustrates the potential for LiDAR as a technology to assess subtropical forest carbon accurately and to provide a better understanding of how forest ecosystems function in this region.
The (de)Militarization of Humanitarian Aid: A Historical Perspective
Authors: De Montclos Marc-Antoine
Published: June 2014

Humanitarian workers often complain that international aid to victims of armed conflicts is more and more militarized because relief organizations are embedded into peacekeeping operations, used as a “force multiplier”, or manipulated as an instrument of diplomacy by proxy. Historically, however, charity has always been a military issue in times of war. We can distinguish four types of militarization of relief organizations in this regard. First is the use of charities to make “war by proxy”, as in Afghanistan or Nicaragua in the 1980s. The second pattern is “embedment”, like the Red Cross during the two world wars. The third is “self-defense”, as with the Order of Saint John of Jerusalem (now Malta) in the 12th Century. The fourth, finally, is the model of “International Brigades” alongside the Spanish Republicans in 1936 or various liberation movements in the 1970s. In comparison, humanitarian aid today appears to be much less militarized. However, this perception also depends on the various definitions of the word “humanitarian”.
The Deployment of Carbon Monoxide Wireless Sensor Network (CO-WSN) for Ambient Air Monitoring
Authors: Chaiwatpongsakorn Chaichana , Lu Mingming , Keener Tim , Khang Soon-Jai
Published: June 2014

Wireless sensor networks are becoming increasingly important as an alternative solution for environment monitoring because they can reduce cost and complexity. Also, they can improve reliability and data availability in places where traditional monitoring methods are difficult to site. In this study, a carbon monoxide wireless sensor network (CO-WSN) was developed to measure carbon monoxide concentrations at a major traffic intersection near the University of Cincinnati main campus. The system has been deployed over two weeks during Fall 2010, and Summer 2011–2012, traffic data was also recorded by using a manual traffic counter and a video camcorder to characterize vehicles at the intersection 24 h, particularly, during the morning and evening peak hour periods. According to the field test results, the 1 hr-average CO concentrations were found to range from 0.1–1.0 ppm which is lower than the National Ambient Air Quality Standards (NAAQS) 35 ppm on a one-hour averaging period. During rush hour periods, the traffic volume at the intersection varied from 2,067 to 3,076 vehicles per hour with 97% being passenger vehicles. Furthermore, the traffic volume based on a 1-h average showed good correlation (R2 = 0.87) with the 1-h average CO-WSN concentrations for morning and evening peak time periods whereas CO-WSN results provided a moderate correlation (R2 = 0.42) with 24 hours traffic volume due to fluctuated changes of meteorological conditions. It is concluded that the performance and the reliability of wireless ambient air monitoring networks can be used as an alternative method for real time air monitoring.
Continuous Flow Atmospheric Pressure Laser Desorption/Ionization Using a 6–7-µm-Band Mid-Infrared Tunable Laser for Biomolecular Mass Spectrometry
Authors: Hiraguchi Ryuji , Hazama Hisanao , Senoo Kenichirou , Yahata Yukinori , Masuda Katsuyoshi , Awazu Kunio
Published: June 2014

A continuous flow atmospheric pressure laser desorption/ionization technique using a porous stainless steel probe and a 6–7-µm-band mid-infrared tunable laser was developed. This ion source is capable of direct ionization from a continuous flow with a high temporal stability. The 6–7-µm wavelength region corresponds to the characteristic absorption bands of various molecular vibration modes, including O–H, C=O, CH3 and C–N bonds. Consequently, many organic compounds and solvents, including water, have characteristic absorption peaks in this region. This ion source requires no additional matrix, and utilizes water or acetonitrile as the solvent matrix at several absorption peak wavelengths (6.05 and 7.27 µm, respectively). The distribution of multiply-charged peptide ions is extremely sensitive to the temperature of the heated capillary, which is the inlet of the mass spectrometer. This ionization technique has potential for the interface of liquid chromatography/mass spectrometry (LC/MS).
A Class of Promising Acaricidal Tetrahydroisoquinoline Derivatives: Synthesis, Biological Evaluation and Structure-Activity Relationships
Authors: Yang Rui , Ruan Qiao , Zhang Bing-Yu , Zheng Zuo-Lue , Miao Fang , Zhou Le , Geng Hui-Ling
Published: June 2014

As part of our continuing research on isoquinoline acaricidal drugs, this paper reports the preparation of a series of the 2-aryl-1-cyano-1,2,3,4-tetrahydroisoquinolines with various substituents on the N-phenyl ring, their in vitro acaricidal activities against Psoroptes cuniculi, a mange mite, and discusses their SAR as well. The structures of all compounds, including 12 new ones, were elucidated by analysis of UV, IR, NMR, ESI-MS, HR-MS spectra and X-ray diffraction experiments. All target compounds showed varying degrees of activity at 0.4 mg/mL. Compound 1 showed the strongest activity, with a 50% lethal concentration value (LC50) of 0.2421 μg/mL and 50% lethal time value (LT50) of 7.79 h, comparable to the standard drug ivermectin (LC50 = 0.2474 μg/mL; LT50 = 20.9 h). The SAR showed that the substitution pattern on the N-aromatic ring exerted a significant effect on the activity. The substituents 2'-F, 3'-F, 2'-Cl, 2'-Br and 2'-CF3 remarkably enhanced the activity. Generally, for the isomers with the same substituents at different positions, the order of the activity was ortho > meta > para. It was concluded that the target compounds represent a class of novel promising candidates or lead compounds for the development of new tetrahydroisoquinoline acaricidal agents.
Article Expression, Purification, and Characterization of Cu/ZnSOD from Panax Ginseng
Authors: Ding Dayong , Liu Shichao , Wang Kai , Huang Lihong , Zhao Jisheng
Published: June 2014

Superoxide dismutase (SOD) has a strong antioxidant effect, but the traditional SOD extraction method is not the most efficient method of SOD amplification. In this study, we report the cloning of the Cu/ZnSOD gene from Panax ginseng into a temperature-regulated expression plasmid, pBV220. Cu/ZnSOD inclusion bodies were expressed in E. coli at a high level. Then, the inclusion bodies were purified by ion-exchange chromatography and molecular sieve chromatography. Finally, we obtained stable SOD in the bacterial broth, with a protein content of 965 mg/L and enzyme specific activity of 9389.96 U/mg. These results provide a foundation for future studies on the antioxidant mechanisms of ginseng and the development and application of ginseng Cu/ZnSOD.
Low Molecular Weight Chitosan (LMWC)-based Polyplexes for pDNA Delivery: From Bench to Bedside
Authors: Agirre Mireia , Zarate Jon , Ojeda Edilberto , Puras Gustavo , Desbrieres Jacques , Pedraz Jose
Published: June 2014

Non-viral gene delivery vectors are emerging as a safer alternative to viral vectors. Among natural polymers, chitosan (Ch) is the most studied one, and low molecular weight Ch, specifically, presents a wide range of advantages for non-viral pDNA delivery. It is crucial to determine the best process for the formation of Low Molecular Weight Chitosan (LMWC)-pDNA complexes and to characterize their physicochemical properties to better understand their behavior once the polyplexes are administered. The transfection efficiency of Ch based polyplexes is relatively low. Therefore, it is essential to understand all the transfection process, including the cellular uptake, endosomal escape and nuclear import, together with the parameters involved in the process to improve the design and development of the non-viral vectors. The aim of this review is to describe the formation and characterization of LMWC based polyplexes, the in vitro transfection process and finally, the in vivo applications of LMWC based polyplexes for gene therapy purposes.
Diffusion Maps for Multimodal Registration
Authors: Piella Gemma
Published: June 2014

Multimodal image registration is a difficult task, due to the significant intensity variations between the images. A common approach is to use sophisticated similarity measures, such as mutual information, that are robust to those intensity variations. However, these similarity measures are computationally expensive and, moreover, often fail to capture the geometry and the associated dynamics linked with the images. Another approach is the transformation of the images into a common space where modalities can be directly compared. Within this approach, we propose to register multimodal images by using diffusion maps to describe the geometric and spectral properties of the data. Through diffusion maps, the multimodal data is transformed into a new set of canonical coordinates that reflect its geometry uniformly across modalities, so that meaningful correspondences can be established between them. Images in this new representation can then be registered using a simple Euclidean distance as a similarity measure. Registration accuracy was evaluated on both real and simulated brain images with known ground-truth for both rigid and non-rigid registration. Results showed that the proposed approach achieved higher accuracy than the conventional approach using mutual information.
Railway Crossing Risk Area Detection Using Linear Regression and Terrain Drop Compensation Techniques
Authors: Chen Wen-Yuan , Wang Mei , Fu Zhou-Xing
Published: June 2014

Most railway accidents happen at railway crossings. Therefore, how to detect humans or objects present in the risk area of a railway crossing and thus prevent accidents are important tasks. In this paper, three strategies are used to detect the risk area of a railway crossing: (1) we use a terrain drop compensation (TDC) technique to solve the problem of the concavity of railway crossings; (2) we use a linear regression technique to predict the position and length of an object from image processing; (3) we have developed a novel strategy called calculating local maximum Y-coordinate object points (CLMYOP) to obtain the ground points of the object. In addition, image preprocessing is also applied to filter out the noise and successfully improve the object detection. From the experimental results, it is demonstrated that our scheme is an effective and corrective method for the detection of railway crossing risk areas.
Vibration Sensor-Based Bearing Fault Diagnosis Using Ellipsoid-ARTMAP and Differential Evolution Algorithms
Authors: Liu Chang , Wang Guofeng , Xie Qinglu , Zhang Yanchao
Published: June 2014

Effective fault classification of rolling element bearings provides an important basis for ensuring safe operation of rotating machinery. In this paper, a novel vibration sensor-based fault diagnosis method using an Ellipsoid-ARTMAP network (EAM) and a differential evolution (DE) algorithm is proposed. The original features are firstly extracted from vibration signals based on wavelet packet decomposition. Then, a minimum-redundancy maximum-relevancy algorithm is introduced to select the most prominent features so as to decrease feature dimensions. Finally, a DE-based EAM (DE-EAM) classifier is constructed to realize the fault diagnosis. The major characteristic of EAM is that the sample distribution of each category is realized by using a hyper-ellipsoid node and smoothing operation algorithm. Therefore, it can depict the decision boundary of disperse samples accurately and effectively avoid over-fitting phenomena. To optimize EAM network parameters, the DE algorithm is presented and two objectives, including both classification accuracy and nodes number, are simultaneously introduced as the fitness functions. Meanwhile, an exponential criterion is proposed to realize final selection of the optimal parameters. To prove the effectiveness of the proposed method, the vibration signals of four types of rolling element bearings under different loads were collected. Moreover, to improve the robustness of the classifier evaluation, a two-fold cross validation scheme is adopted and the order of feature samples is randomly arranged ten times within each fold. The results show that DE-EAM classifier can recognize the fault categories of the rolling element bearings reliably and accurately.
Alphavirus-Based Vaccines
Authors: Lundstrom Kenneth
Published: June 2014

Alphavirus vectors have demonstrated high levels of transient heterologous gene expression both in vitro and in vivo and, therefore, possess attractive features for vaccine development. The most commonly used delivery vectors are based on three single-stranded encapsulated alphaviruses, namely Semliki Forest virus, Sindbis virus and Venezuelan equine encephalitis virus. Alphavirus vectors have been applied as replication-deficient recombinant viral particles and, more recently, as replication-proficient particles. Moreover, in vitro transcribed RNA, as well as layered DNA vectors have been applied for immunization. A large number of highly immunogenic viral structural proteins expressed from alphavirus vectors have elicited strong neutralizing antibody responses in multispecies animal models. Furthermore, immunization studies have demonstrated robust protection against challenges with lethal doses of virus in rodents and primates. Similarly, vaccination with alphavirus vectors expressing tumor antigens resulted in prophylactic protection against challenges with tumor-inducing cancerous cells. As certain alphaviruses, such as Chikungunya virus, have been associated with epidemics in animals and humans, attention has also been paid to the development of vaccines against alphaviruses themselves. Recent progress in alphavirus vector development and vaccine technology has allowed conducting clinical trials in humans.
Exposure of Mediterranean Countries to Ocean Acidification
Authors: Hilmi Nathalie , Allemand Denis , Cinar Mine , Cooley Sarah , Hall-Spencer Jason , Haraldsson Gunnar , Hattam Caroline , Jeffree Ross , Orr James , Rehdanz Katrin , Reynaud Stéphanie , Safa Alain , Dupont Sam
Published: June 2014

This study examines the potential effects of ocean acidification on countries and fisheries of the Mediterranean Sea. The implications for seafood security and supply are evaluated by examining the sensitivity of the Mediterranean to ocean acidification at chemical, biological, and macro-economic levels. The limited information available on impacts of ocean acidification on harvested (industrial, recreational, and artisanal fishing) and cultured species (aquaculture) prevents any biological impact assessment. However, it appears that non-developed nations around the Mediterranean, particularly those for which fisheries are increasing, yet rely heavily on artisanal fleets, are most greatly exposed to socioeconomic consequences from ocean acidification.
Public Perception of Water Consumption and Its Effects on Water Conservation Behavior
Authors: Fan Liangxin , Wang Fei , Liu Guobin , Yang Xiaomei , Qin Wei
Published: June 2014

The usual perception of consumers regarding water consumption is that their bills do not match their actual water consumption. However, this mismatch has been insufficiently studied; particularly for cases related to specific water-use patterns, water conservation practices, and user socio-demographics. In this study, a total of 776 households in 16 villages situated in the rural Wei River Basin are investigated to address the gap in the literature. Questionnaires and 3-day water diaries are used for data collection and comparison. Results show that significant relations exist between perceived water consumption and actual water consumption. Participants have different perceptions of specific water-use patterns. Participants tend to underestimate their outdoor and kitchen water consumption and overestimate their indoor water consumption. Females and elder consumers accurately estimate their water consumption, whereas consumers with high education levels and incomes underestimate their actual water consumption. The groups who can accurately estimate water consumption have better water conservation consciousness and water conservation practices than those who underestimate their water consumption. The huge disparities highlighted by the results suggest that community policies and programs to improve public water conservation consciousness or practices must be implemented to enhance consumer understanding of water consumption.
Local Festival Quality and the Application of a Revised Importance–Performance Analysis: The Case of the Jirisan Cheon-Wang Festival
Authors: Kim Namhyun , Ahn Young-Joo , Wicks Bruce E.
Published: June 2014

The purposes of this research are twofold: (1) to empirically identify which attributes of festival quality affect attendees' satisfaction; and (2) to utilize a new method, a revised Importance– Performance Analysis (IPA) technique to monitor festival quality and to assess festival
performance. The findings suggest that three festival quality attributes affected the overall satisfaction of the festival: festival program content, program operation/organization, and festival advertising/PR. Discovering quality attributes is the utmost task among practitioners in order
to differentiate products and achieve competitive advantage. This study also extends the research on local festival/event quality and the impacts on satisfaction using the three-factor theory of customer satisfaction. It also provides empirical evidence that demonstrates the necessity of implicit
importance derived from performance instead of self-rated importance in traditional IPA models.
Image Impacts of Planned Special Events: Literature Review and Research Agenda
Authors: Lai Kun , Li Yiping
Published: June 2014

In the era of globalization, planned special events of various kinds have been playing increasingly important roles in (re)shaping projected and perceived images of the hosts and other stakeholders involved. This article aims to review previous studies on such roles historically, analytically,
and synthetically. The historical review reveals the general growing pattern of the existing studies; the analytical review captures their salient structural components; and the synthetic review assesses their progress made and identifies some important problems yet to be further solved. This
article is useful to promote future research on the topic and facilitate strategic image management via hosting sport, sociocultural, political, and business events.
Pyrite nanoparticles as a Fenton-like reagent for in situ remediation of organic pollutants
Authors: Gil-Lozano Carolina , Losa-Adams Elisabeth , F.-Dávila Alfonso , Gago-Duport Luis
Published: June 2014

The Fenton reaction is the most widely used advanced oxidation process (AOP) for wastewater treatment. This study reports on the use of pyrite nanoparticles and microparticles as Fenton reagents for the oxidative degradation of copper phthalocyanine (CuPc) as a representative contaminant. Upon oxidative dissolution in water, pyrite (FeS2) particles can generate H2O2 at their surface while simultaneously promoting recycling of Fe3+ into Fe2+ and vice versa. Pyrite nanoparticles were synthesized by the hot injection method. The use of a high concentration of precursors gave individual nanoparticles (diameter: 20 nm) with broader crystallinity at the outer interfaces, providing a greater number of surface defects, which is advantageous for generating H2O2. Batch reactions were run to monitor the kinetics of CuPc degradation in real time and the amount of H2O2. A markedly greater degradation of CuPc was achieved with nanoparticles as compared to microparticles: at low loadings (0.08 mg/L) and 20 h reaction time, the former enabled 60% CuPc removal, whereas the latter enabled only 7% removal. These results confirm that the use of low concentrations of synthetic nanoparticles can be a cost effective alternative to conventional Fenton procedures for use in wastewater treatment, avoiding the potential risks caused by the release of heavy metals upon dissolution of natural pyrites.
Molecular recognition of surface-immobilized carbohydrates by a synthetic lectin
Authors: Rauschenberg Melanie , Fritz Eva-Corrina , Schulz Christian , Kaufmann Tobias , Ravoo Bart Jan
Published: June 2014

The molecular recognition of carbohydrates and proteins mediates a wide range of physiological processes and the development of synthetic carbohydrate receptors (“synthetic lectins”) constitutes a key advance in biomedical technology. In this article we report a synthetic lectin that selectively binds to carbohydrates immobilized in a molecular monolayer. Inspired by our previous work, we prepared a fluorescently labeled synthetic lectin consisting of a cyclic dimer of the tripeptide Cys-His-Cys, which forms spontaneously by air oxidation of the monomer. Amine-tethered derivatives of N-acetylneuraminic acid (NANA), β-D-galactose, β-D-glucose and α-D-mannose were microcontact printed on epoxide-terminated self-assembled monolayers. Successive prints resulted in simple microarrays of two carbohydrates. The selectivity of the synthetic lectin was investigated by incubation on the immobilized carbohydrates. Selective binding of the synthetic lectin to immobilized NANA and β-D-galactose was observed by fluorescence microscopy. The selectivity and affinity of the synthetic lectin was screened in competition experiments. In addition, the carbohydrate binding of the synthetic lectin was compared with the carbohydrate binding of the lectins concanavalin A and peanut agglutinin. It was found that the printed carbohydrates retain their characteristic selectivity towards the synthetic and natural lectins and that the recognition of synthetic and natural lectins is strictly orthogonal.
Clinical and Serological Predictors of Remission in Rheumatoid Arthritis Are Dependent on Treatment Regimen
Authors: Ma Margaret H.Y. , Scott Ian C. , Dahanayake Chanaka , Cope Andrew P. , Scott David L.
Published: June 2014

Objective.

Early intensive treatment is now the cornerstone for the management of rheumatoid arthritis (RA). In the era of personalized medicine, when treatment is becoming more individualized, it is unclear from the current literature whether all patients with RA benefit equally from such intensive therapies. We investigated the benefit of different treatment regimens on remission rates when stratified to clinical and serological factors.

Methods.

The Combination Anti-rheumatic Drugs in Early Rheumatoid Arthritis (CARDERA) trial recruited patients with RA of less than 2 years’ duration who had active disease. The trial compared 4 treatment regimens: methotrexate monotherapy, 2 different double therapy regimens (methotrexate and cyclosporine or methotrexate and prednisolone) and 3-drug therapy. Clinical predictors included age, male sex, and tender joint count (TJC) and serological biomarkers included rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPA).

Results.

Patients who were male, over 50 years, had ≥ 6 TJC, were RF-IgM–positive, or ACPA-positive were more likely to achieve remission at 24 months using 3-drug therapy compared to monotherapy (OR 2.99, 4.95, 2.71, 2.54, and 3.52, respectively). There were no differences in response to monotherapy and 3-drug therapy if patients were female, under 50 years, had < 6 TJC, or were seronegative.

Conclusion.

Early intensive regimens have become the gold standard in the treatment of early RA. Our study suggests that this intensive approach is only superior to monotherapy in certain subsets of patients. Although these are unlikely to be the only predictors of treatment response, our study brings us a step closer to achieving personalized medicine in RA.
Female Sex and Oligoarthritis Category Are Not Risk Factors for Uveitis in Italian Children with Juvenile Idiopathic Arthritis
Authors: Calandra Serena , Gallo Maria Chiara , Consolaro Alessandro , Pistorio Angela , Lattanzi Bianca , Bovis Francesca , Muratore Valentina , De Marco Riccardo , Martini Alberto , Ravelli Angelo
Published: June 2014

Objective.

To investigate the risk factors for chronic anterior uveitis in patients with juvenile idiopathic arthritis (JIA).

Methods.

The clinical charts of patients followed between January 1987 and December 2011 were reviewed to establish whether they had uveitis. Inclusion criteria were a diagnosis of JIA and a disease category of persistent oligoarthritis, extended oligoarthritis, rheumatoid factor-negative polyarthritis, psoriatic arthritis, or undifferentiated arthritis. Risk factors included sex, age at arthritis onset, disease category, and antinuclear antibody (ANA) status. The association of risk factors with occurrence of uveitis was evaluated by survival analysis, with first episode of uveitis as the event of interest, and Cox regression analysis.

Results.

Of a total of 1189 patients, 278 (23.4%) had uveitis a median of 1.1 years after onset of arthritis. There was no difference in the cumulative probability of developing uveitis between males and females and between patients belonging to different JIA categories, whereas uveitis was strongly associated with age at arthritis onset ≤ 3.5 years and positive ANA. Patients possessing the latter 2 factors in combination had a greater probability of having uveitis than patients who had either of them alone.

Conclusion.

In our patients, the risk of uveitis was related to younger age at onset of arthritis and presence of ANA, but not to female sex and disease category. This finding suggests that the patients who require the most intensive ophthalmologic screening are those who have early-onset JIA and are ANA-positive, regardless of their sex or disease subtype.
The Diagnostic Performance of Anterior Knee Pain and Activity-related Pain in Identifying Knees with Structural Damage in the Patellofemoral Joint: The Multicenter Osteoarthritis Study
Authors: Stefanik Joshua J. , Neogi Tuhina , Niu Jingbo , Roemer Frank W. , Segal Neil A. , Lewis Cora E. , Nevitt Michael , Guermazi Ali , Felson David T.
Published: June 2014

Objective.

To determine the diagnostic test performance of location of pain and activity-related pain in identifying knees with patellofemoral joint (PFJ) structural damage.

Methods.

The Multicenter Osteoarthritis Study is a US National Institutes of Health-funded cohort study of older adults with or at risk of knee osteoarthritis. Subjects identified painful areas around the knee on a knee pain map and the Western Ontario and McMaster Universities Osteoarthritis Index was used to assess pain with stairs and walking on level ground. Cartilage damage and bone marrow lesions were assessed from knee magnetic resonance imaging. We determined the sensitivity, specificity, positive and negative predictive values for presence of anterior knee pain (AKP), pain with stairs, absence of pain while walking on level ground, and combinations of tests in discriminating knees with isolated PFJ structural damage from those with isolated tibiofemoral joint (TFJ) or no structural damage. Knees with mixed PFJ/TFJ damage were removed from our analyses because of the inability to determine which compartment was causing pain.

Results.

There were 407 knees that met our inclusion criteria. “Any” AKP had a sensitivity of 60% and specificity of 53%; and if AKP was the only area of pain, the sensitivity dropped to 27% but specificity rose to 81%. Absence of moderate pain with walking on level ground had the greatest sensitivity (93%) but poor specificity (13%). The combination of “isolated” AKP and moderate pain with stairs had poor sensitivity (9%) but the greatest specificity (97%) of strategies tested.

Conclusion.

Commonly used questions purported to identify knees with PFJ structural damage do not identify this condition with great accuracy.
High Prevalence of Metabolic Syndrome and of Insulin Resistance in Psoriatic Arthritis is Associated with the Severity of Underlying Disease
Authors: Haroon Muhammad , Gallagher Phil , Heffernan Eric , FitzGerald Oliver
Published: June 2014

Objective.

To investigate the prevalence of metabolic syndrome (MetS) and of insulin resistance (IR) in an ethnically homogeneous cohort of established psoriatic arthritis (PsA), and to identify clinical associations of MetS and IR in patients with PsA.

Methods.

A cohort of 283 patients with PsA all meeting ClASsification for Psoriatic ARthritis (CASPAR) criteria was included. All underwent detailed skin and rheumatologic assessments, along with cardiovascular risk factor evaluation. IR was defined as an elevated homeostasis model assessment (HOMA-IR) value of > 2.5. Severe PsA was defined as the presence of 1 or more of the PsA-related radiographic damage features (peripheral joint erosions, osteolysis, sacroiliitis), and PsA requiring tumor necrosis factor inhibitor therapy.

Results.

The demographic and clinical characteristics of the cohort were mean age 54.6 ± 12 years, 52% female, mean PsA duration 19 ± 9 years. MetS was present in 44% of the studied patients (n = 283). On multiple regression analysis, a significant association of MetS was noted with more severe PsA (OR 4.47, p < 0.001), higher smoking pack-years (OR 1.03, p = 0.02), and worse EQ-5D scores (OR 1.28, p = 0.02). Data on IR were available for 263 patients, and among them, the mean HOMA-IR was 1.43 ± 1.09. Forty-one patients (16%) had IR. On multiple regression analysis, a significant association of IR was noted with more severe PsA (OR 3.49, p = 0.03), later psoriasis age of onset (OR 1.07, p = 0.001), and higher body mass index (OR 1.22, p < 0.001).

Conclusion.

Among patients with PsA, MetS and IR are highly prevalent, and are independently associated with the severity of underlying PsA.
pragmatics of things: Materiality and constraint in fan practices
Authors: Woo Benjamin
Published: June 2014

Although, as qualitative consumer research and material culture studies have demonstrated, objects can be rich sources of meaning and stability, they also entail basic limitations on human action. Interviews conducted as part of a study of one city's nerd-culture scene permitted analysis of the constraints that materiality imposes on fan activity. Fans must have access to certain physical objects in order to realize their practices, and collecting, storing, and purging these objects in domestic spaces constitutes a pragmatics that sets limits and exerts pressures on participants.
Peril-sensitive sunglasses, superheroes in miniature, and pink polka-dot boxers: Artifact and collectible video game feelies, play, and the paratextual gaming experience
Authors: Peters Ian M.
Published: June 2014

Material artifacts included in video game packaging, referred to in the industry as feelies, operate as media paratexts that are both extensions of and separate from the video games that inspired them. Although most discourses on video game feelies are centered on 1980s text-based adventure games, feelies have continually been included in contemporary games, albeit primarily in collector's or special editions. To explore the diversity of feelies and how they are able to generate their own texts away from the digital game itself, I identify two specific types of feelies: artifact feelies, which are life-size reproductions of objects from within the game space, and collectible feelies, which serve as extensions of the game space into the physical realm but tend to include objects more frequently associated with fan collecting activities. Taking an interdisciplinary approach that includes material culture studies and media studies, I show how feelies allow scholars to gain further insight into how screen media operate away from the screens themselves, how the accumulation of material objects in the digital age encourages us to reevaluate our notions of the material and the immaterial, and how the concept of play is crucial to understanding how these objects are reappropriated in ways that move beyond their originally intended use.
Fitting "Glee" in your mailbox
Authors: Wordplay .
Published: June 2014

A Glee fan's personal fannish odyssey from the Archive of Our Own, LiveJournal, and Tumblr to the creation of physical objects.
Cosplaying the media mix: Examining Japan's media environment, its static forms, and its influence on cosplay
Authors: Ogonoski Matthew
Published: June 2014

Cosplay—costume role-play—has dramatically increased in popularity over the past 20 years in conjunction with the cultural institution of anime, comic book, manga, science fiction, and other related fandom conventions. Cosplay was prominently established in Japan before gaining attention in North America. In this article I analyze the significance of those Japanese origins in relation to the experience of a unique media environment. The aesthetics and practices of cosplay in Japan are fundamentally informed by a specific ontological characteristic of Japanese anime, manga, and ancillary forms: the static image. Of essential importance to these consumption practices—both materially and conceptually—is the phenomenon of the anime database: an archive of static images that is continually accessed for the purposes of understanding, consuming, and creating new media. Through a detailed discussion of Hiroki Azuma's conception of the moe database, Thomas Lamarre's discussion of the cel bank as a material requisite of the database, and Marc Steinberg's assessment of the media mix, I extend the phenomenological affects of this media environment and its static images to the act of cosplay posing—an act that aspires to create a mimetic and collective connection between cosplayers and particular media images. This exploratory platform will permit me to develop specific conceptions of Japan's complex media environment and its transformations of material forms into ephemeral consumption practices.
Written on the body: Experiencing affect and identity in my fannish tattoos
Authors: Jones Bethan
Published: June 2014

This autoethnographic account of fan tattoos emphasizes the importance of affect and identity in relation to fan tattooing.
Exhibiting fandom: A museological perspective
Authors: Hoebink Dorus , Reijnders Stijn , Waysdorf Abby
Published: June 2014

Fandom and the collecting of objects are interwoven phenomena. The insights of museum studies may be brought to bear on the study of fan objects to provide a better understanding of fan collections and fan collecting. A museum studies focus assesses the meanings and interpretations of material objects as well as the workings and dynamics of collections, collectors, and collecting. With science fiction fan collections used as examples, we highlight object and museum theory, demonstrating how this theory and its conceptual tools can be used to analyze fan culture. We then apply these tools to a case study: the EMP Museum in Seattle, Washington, a museum in the United States largely dedicated to the genre of science fiction. When fan collections enter the realm of museums, fandom becomes a world that involves touching, smelling, collecting, and controlling objects.
From Dalek half balls to Daft Punk helmets: Mimetic fandom and the crafting of replicas
Authors: Hills Matt
Published: June 2014

Mimetic fandom is a surprisingly understudied mode of (culturally masculinized) fan activity in which fans research and craft replica props. Mimetic fandom can be considered as (in)authentic and (im)material, combining noncommercial status with grassroots marketing or brand reinforcement as well as fusing an emphasis on material artifacts with Web 2.0 collective intelligence. Simply analyzing mimetic fandom as part of fannish material culture fails to adequately assess the nonmaterial aspects of this collaborative creativity. Two fan cultures are taken as case studies: Dalek building groups and Daft Punk helmet constructors. These diverse cases indicate that mimetic fandom has a presence and significance that moves across media fandoms and is not restricted to the science fiction, fantasy, and horror followings with which it is most often associated. Mimetic fandom may be theorized as an oscillatory activity that confuses binaries and constructions of (academic/fan) authenticity. This fan practice desires and pursues a kind of ontological bridging or unity—from text to reality—that is either absent or less dominant in many other fan activities such as cosplay, screen-used prop collecting, and geographical pilgrimage. Fan studies may benefit from reassessing the place of mimesis, especially in order to theorize fan practices that are less clearly transformative in character.
Evaluation of the Use of Two Teaching Techniques in Engineering
Authors: Salas Jose Antonio Alvarez , Segundo J. , Álvarez C. , Arellano J. C. , Pérez A. A.
Published: June 2014

This paper presents an analysis of the practical implementation of two teaching techniques so-called Problem-Based Learning and Cooperative Learning. These techniques were applied to some courses in the Department of Mechanical and Electrical Engineering and evaluated through assessment rubrics.

In a sample of students and teachers, the assessment rubrics were applied to numerically evaluate the proportion of each course, in which the teacher uses traditional teaching versus teaching for meaningful learning. The results of the presented analysis allow to verify the use of these teaching techniques by professors of the Department of Mechanical and Electrical Engineering.

This activity was developed as a part of the work established by the Institutional Development Plan of the Faculty of Engineering, which includes the strategic objective of developing an innovative educational model in the following ten years.
A Shift from Teacher Centered to Learner Centered Approach
Authors: Schreurs Jeanne , Dumbraveanu Roza
Published: June 2014

In the framework of the project Western Eastern Teachers' Education Network (WETEN) funded by the Tempus program the network of university teachers were established to share expertise on effective teaching and learning in universities. This network for pedagogical innovation in higher education brought together the experts from EU to share good practice and new teaching methods with academic staff from two eastern countries, Moldova and Ukraine. The learner centered concept was analyzed and guidelines for creating learner centered courses were developed and piloted. The concepts and some experiences in course design were also implemented by trained teachers in the developed courses within the WETEN project.
Exploring Lecturers' Perceptions of Learning Management System: An Empirical Study Based on TAM
Authors: Goh Wei Wei , Hong Jer Lang , Gunawan Wilson
Published: June 2014

With the pervasive take-up and presence of digital technologies, learning management system (LMS) is popular for its open accessibility and its interactive nature. Implementation of LMS has become part of the strategic plan in higher education institution to enhance the flexibility in teaching and learning. It is essential to explore the perceptions of users in using the LMS in order to inform stakeholders the positive influencing aspects and improve the negative factors in the future. This study investigates the perception of lecturers in using LMS in term of perceived usefulness and perceived ease of use for teaching purposes. Technology Acceptance Model (TAM) is used as the research framework to design the questionnaire. An online questionnaire was created to address the research questions. The results reveal that lecturers do not react positively towards perceived ease of use of Moodle for teaching. Lecturers treat Moodle as content repository and do not fully utilize the interactive features in Moodle. It was found that usability issues, interaction and communication issues had a negative impact on the lecturers' perception.
Netiquette in Electronic Communication
Authors: Kozík Tomáš , Slivová Jozefína
Published: June 2014

Electronic mail and electronic communications systems are considered significant and effective tools of communication. One of the most widespread electronic communication tools is e - mail communication. In order to avoid misinterpretation of the report on the side of the recipient, it is need to pay attention to the writing of e - mail messages as well as to their content.

With the continuous expansion of the use of electronic communication there have gradually developed certain rules of etiquette in electronic communications. The existing rules of the propriety ones are expressed in the term " etiqutte " and are not automatically applied in the new communications environment - media.

For electronic communication, the new rules of etiquette have been stabilised into a term NETIQUETTE. The word netiquette was created by combining words NET (net) and ETIKETA (a set of rules of social behavior and habits). Netiquette constitutes the rules of the behavior of users on a network. Although the netiquette is merely "an unwritten set of rules", their not using can be understood as a type of disrespect.

Analysis of knowledge of domestic and foreign sources as well as results of a survey confirmed the justification of paying attention to the education of individuals in NETIQUETTE, irrespective of the degree of education.