bluuebunny/crossref_metadata_2025 huggingface dataset:
Cabozantinib in Patients with Advanced Merkel Cell Carcinoma
Authors: Rabinowits Guilherme , Lezcano Cecilia , Catalano Paul J. , McHugh Patricia , Becker Hailey , Reilly Megan M. , Huang Julian , Tyagi Ayushi , Thakuria Manisha , Bresler Scott C. , Sholl Lynette M. , Shapiro Geoffrey I. , Haddad Robert , DeCaprio James A.
Published: February 2018

Background

This study sought to determine the efficacy and safety profile of cabozantinib in patients with advanced Merkel cell carcinoma (MCC).

Experimental Design

This prospective, phase II, single-institution trial enrolled patients with platinum-failure, recurrent/metastatic MCC to receive cabozantinib 60 mg orally daily until disease progression, withdrawal from study, or severe toxicity. The primary endpoint was disease control rate. Secondary endpoints included overall survival (OS), progression-free survival (PFS), and toxicity. Immunohistochemistry for VEGFR-2, MET, and HGF expression and next-generation sequencing of tumor tissue were performed and correlated with outcome.

Results

Eight patients were accrued from January 24, 2014, to June 8, 2016. The study was closed prematurely because of toxicity and lack of responses. The most frequent adverse events were grades 1 and 2 and included anorexia, fatigue, nausea, hypothyroidism, and dysgeusia. Two patients developed nonhealing, painful ulcers and tumor-skin fistula. One patient had stable disease for 8 months. One patient withdrew from the study after 2 weeks of therapy because of adverse events. Three patients required dose reduction because of toxicity. Median PFS and OS were 2.1 and 11.2 months, respectively. No expression of MET, HGF, or VEGFR-2 was identified in tumor cells by immunohistochemistry of patients’ tissue samples.

Conclusion

Cabozantinib was poorly tolerated and did not demonstrate activity in patients with recurrent/metastatic, platinum-failure MCC. It is unclear whether preselection of patients with the specific upregulation or genetic alteration in the targets for cabozantinib would have changed the results of this study. (Clinical trial identification number: NCT02036476)

Implications for Practice

This phase II study demonstrated poor tolerability and lack of activity of cabozantinib in an unselected group of patients with advanced Merkel cell carcinoma. Although it is unclear whether preselection of patients with the specific upregulation and genetic alterations in targets for cabozantinib would have changed the results of this study, this would have likely led to an extremely rare patient population that would take many years to accrue.
Waste-loofah-derived carbon micro/nanoparticles for lithium ion battery anode
Authors: Hou Hongying , Yu Chengyi , Liu Xianxi , Yao Yuan , Liao Qishu , Dai Zhipeng , Li Dongdong
Published: February 2018

It is very important to recycle the waste biomass resources for the environment protection and the circular economy. For this purpose, the waste old loofah was carbonized at 800°C for 1 h in the inert nitrogen gas (N2) atmosphere for lithium ion battery anode. The resultant waste-loofah-derived carbon was investigated by scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, nitrogen adsorption and desorption, galvanostatic charge/discharge, cyclic voltammetry and alternating current impedance. The results suggested that the waste-loofah-derived carbon powders consisted of many concomitant microparticles and nanoparticles with a specific surface area of about 492 m2/g. Furthermore, the waste-loofah-derived carbon anode also delivered high electrochemical lithium (Li) storage activity. For example, the initial specific discharge capacity was about 697 mAh/g, and the reversible discharge capacity was about 187 mAh/g at 1000 mA/g for 500 cycles and still about 98 mAh/g even at 3000 mA/g for 500 cycles, exhibiting good cycling stability. High surface area and structural defects may jointly contribute to high electrochemical performances.
Streaming Media in an Uncertain Legal Environment: A Model Policy and Best Practices for Academic Libraries
Authors: Adams Tina M , Holland Claudia C
Published: February 2018

As VCRs and DVD players become obsolete, online course offerings increase, and flipped pedagogy becomes ubiquitous, academic librarians are frequently confronted with requests from instructors for streaming media. The authors of this article describe the reasoning for and process by which a policy and best practices to manage streaming media requests were developed at a large public university. This policy is guided by the principles set forth in U.S. Copyright Act’s fair use doctrine (17 U.S.C. § 107) and ARL’s Code of Best Practices in Fair Use for Academic and Research Libraries (2012). The policy also includes a workflow for delivering streaming, ADA-compliant video content that cannot be licensed via conventional library means. Moreover, the comparative costs of purchasing subscription video collections versus licensing individual streaming videos at George Mason University are provided for the fiscal years 2013 through 2016.
Drug loss during tablet crushing v1
Authors: J Steadman Kathryn
Published: February 2018

This method describes the comparison of paracetamol quantification of a whole tablet vs a tablet that has been crushed in a proprietary tablet crusher. In this case we have used paracetamol as the model drug, but this basic approach can be applied to any solid dose form with appropriate adjustment of solvents (to ensure drug is completely dissolved for measurement) and UV wavelength. The use of HPLC can be substituted in place of simple UV if there is any indication of interference at the UV wavelength.
Health-e Babies App Trial v1
Authors: Dalton Julia
Published: February 2018

Background The use of mobile technology such as phone applications (apps) has been proposed as an efficient means of providing health and clinical information in a variety of healthcare settings. We developed the Health-e Babies app as an Android smart phone application for pregnant women attending a tertiary hospital in a low socio-economic community, with the objective of providing health information about early pregnancy that would increase maternal confidence and reduce anxiety. Based on our earlier research, this form of health communication was viewed as a preferred source of information for women of reproductive age. However, the pilot study had a poor participation rate with 76% (n=94) not completing the study requirements. These initial findings raised some very important issues in relation to the difficulties of engaging women with a pregnancy app. This paper analyses the characteristics of the participants who did not complete the study requirements in an attempt to identify potential barriers associated with the implementation of a pregnancy app. Methods This retrospective review of quantitative and qualitative data collected at the commencement of the Health-e Babies App trial, related to the participant’s communication technology use, confidence in knowing where to seek help and mental health status, maternal-fetal attachment and parenting confidence. Engagement and use of the Health-e Babies App was measured by the completion of a questionnaire about the app and downloaded data from participant’s phones. Mental health status, confidence and self-efficacy were measured by questionnaires. Results All women were similar in terms of age, race, marital status and level of education. Of the 94 women (76%) who did not complete the trial, they were significantly more anxious as indicated by State Trait Anxiety Inventory (p=0.001 Student T-test) and more likely to be unemployed (50% vs 31%, p=0.012 Student T-Test). Conclusion This study provides important information about the challenges associated with the implementation of a pregnancy app in a socially disadvantaged community. The data suggests that factors including social and mental health issues, financial constraints and technological ability can affect women’s engagement with a mobile phone app.
Adhesion performance of a universal adhesive in the root canal: Effect of irrigation/adhesive protocol v1
Authors: Jowkar Zahra
Published: February 2018

Purpose: Universal adhesives are new systems that can be used in etch-and-rinse (ER) and self-etch (SE) modes. This in vitro study evaluated the bonding performance of a universal adhesive in ER mode and SE mode with two irrigants for luting fiber posts in the root canal. Materials and Methods: After separation of the roots from the crowns of 56 maxillary central incisors and endodontic treatment, 10-mm post space was prepared. The roots were divided into seven groups according to irrigant/adhesive protocol used for cementation of posts: 1) sodium hypochlorite (NaOCl) irrigant + acid etching + One-Step Plus, 2) NaOCl + Clearfil SE Bond (CSE) and 3) EDTA + CSE as controls; 4) NaOCl + All-Bond Universal (AB) in ER mode, 5) NaOCl + AB in SE mode, 6) EDTA + AB in SE mode, 7) distilled water + AB in SE mode. Posts were luted using Duo-link. The bonded roots were sectioned into microslices. After push-out bond strength (PBS) testing, data in MPa were analyzed with two-way ANOVA and Tukey test (α=0.05).
Observation of blood pressure guided fluid therapy in a bleeding-resuscitation animal experiment v1
Authors: Öveges Nándor , László Ildikó , Tánczos Krisztián , Németh Márton , Lebák Gábor , Tudor-Drobjewski Bianca-Andreea , Érces Dániel , Kaszaki József , Rudas László , Huber Wolfgang , Molnár Zsolt
Published: February 2018

The current protocol is a bleeding-resuscitation model intended to imitate the effects of severe blood loss and subsequent fluid resuscitation. The experimental subjects were Vietnamese pot-bellied pigs of both sexes weighing 33±4 kg. The animals underwent a 12-hours fasting pre-operatively but had free access to water. Anesthesia was induced by intramuscular injection of a mixture of ketamine (20 mg/kg) and xylazine (2 mg/kg) and maintained with a continuous iv. infusion of Propofol (50 µL/min/kg IV; 6 mg/kg/hr), while analgesia was maintained with intermittent nalbuphine (0.1 mg/kg). After endotracheal intubation, the animals were mechanically ventilated with a Hamilton C1 respirator (Hamilton Medical AG, USA). The tidal volume was set to 10 ml/kg, and the respiratory rate was adjusted to maintain the end-tidal carbon dioxide and partial pressure of arterial carbon dioxide within the range of 35–45 mmHg and the arterial pH between 7.35 and 7.45. The depth of anaesthesia was assessed by checking jaw tone. After induction of anaesthesia, catheters were inserted into the left jugular vein, left external carotid artery and the left femoral artery. For invasive hemodynamic monitoring, a transpulmonary thermodilution catheter (PiCCO, PULSION Medical Systems SE, Munich, Germany) was used. The femoral artery served as the site for arterial blood gas sampling, the central venous line was used for taking central venous blood gas samples and for the injection of cold saline boluses for the thermodilution measurements, whilst the carotid arterial catheter was used for draining blood. A transpubic catheter was placed into the urinary bladder for monitoring renal function. Animals were covered in scrubs and an external heating device was used to maintain physiological body temperature.
Reflection of positron radiation from star surface and shift of inter pulse position in Crab pulsar
Authors:   Institute of Radio Astronomy NAS of Ukraine, Kharkiv, Ukraine, Kontorovich V. M. , Trofymenko S. V. ,   Akhiezer Institute for Theoretical Physics of NSC KIPT, Kharkiv, Ukraine
Published: February 2018

The pulsed radiation from the Crab pulsar consists of the main pulse (MP) and inter pulse (IP), as well as of the extra pulse components appearing at certain frequencies. It has been studied in many frequencies and contains unique information, which is not available for the majority of the pulsars. One of the mysteries of these data, found by Moffett and Hankins twenty years ago, is the shift of the IP at high radio frequencies compared to lower ones and return to its previous position in the more high-frequency optical and X-ray range. We propose the explanation of these mysterious changes with the frequency as a reflection of radiation by relativistic positrons from the stellar surface. The magnetic field of the pulsar in the pole must be inclined to the surface of the star and affects on the discussed processes.
Equity and Inclusion: Expanding the Urban Ecosystem
Authors: McNair Tia Brown , Ramaley Judith A.
Published: February 2018

As our nation grows ever more diverse, the need to ensure that our educational institutions are truly equitable and inclusive becomes more and more urgent. This sense of urgency plays out across a social and political terrain that threatens the very core of our identity as a nation. Our growing diversity is seen by some as a threat to our national security and as the primary cause behind the displacements and angers being created by the ever growing differences that are dividing our country. Our authors see our growing diversity as a much needed and valued source of energy, creativity and a vital contribution to our capacity to thrive in an especially challenging period in our history and are committed to creating educational environments where people of all backgrounds can thrive.
Building a University-wide Agenda for Intercultural Competence and Understanding:  Lessons Learned at the University of Minnesota
Authors: Furco Andrew , Lockhart Kris
Published: February 2018

Furthering intercultural competence in higher education requires colleges and universities to establish an intentional, mission driven strategic plan that embeds intercultural understanding and practice across the institution’s work. To secure broad-based buy-in and support, this plan needs to consider the various ways that different units within the academy define, interpret, and view intercultural work. For large, complex and multi-faceted colleges and universities, building this plan can prove daunting as different parts of the institution will ascribe different meanings, purposes, and intentions to intercultural advancement.In this paper, administrators from the University of Minnesota, who represent units that are highly engaged in intercultural competence work, share some of their struggles and lessons learned in their effort to build a comprehensive, campus-wide strategy to grow intercultural advancement. The administrators initiated this campus-wide strategic work following their participation in an international conference focused on intercultural competence. Since that time, they have developed recommendations for the foundational work required to establish a common university-wide framework and comprehensive plan for institutional intercultural advancement.
Reframing the Dominant Diversity Discourse: Alternate Conversations for Creating Whole System Change
Authors: Golom Frank
Published: February 2018

Diversity and inclusion (D&I) efforts in higher education are decades old, yet progress continues to be slow and elusive for many campuses. Recent events in colleges and universities across the United States suggest that long-standing challenges related to access, equity and inclusion remain as entrenched and intractable as they have ever been, resulting in campus environments that may be unwelcoming or hostile to faculty, staff and students from underrepresented groups. One reason for the partial success of university D&I programs is that they overemphasize individual actors, attitudes and behaviors while neglecting the systemic, organizational cultures in which those actors reside. Drawing on the organization development and change literatures, this paper offers three alternate perspectives for reframing campus diversity work, arguing that all D&I initiatives must consider the 1) contextual, 2) multilevel and 3) systemic nature of change if they are to be robust and successful.
Fighting for Equity and Community in an Urban Research University
Authors: Ho Mary , Sanchez George
Published: February 2018

The equity lens evaluates institutional barriers that prevent students of color from gaining access to resources for college success (Bensimon, 2005). The first-generation college students at the University of Southern California are 16% of the total student body and students of color comprise two-thirds of this population. Since 2008, how to support first generation college students of color in their academic achievement and college success once in college has expanded the discussion beyond access.  By evaluating institutional structures through the equity lens, the response has been to create intentional academic and social programs for first generation college students of color that bridge the academic and student services divide.  Through descriptions of actual programs and stories from students affected by these programs, this essay will discuss innovative approaches to serving first-generation students of color at predominantly white universities.
Lessons Learned About Inclusion While Starting a New College
Authors: Jones Michelle
Published: February 2018

Starting a college from scratch presents a unique opportunity to think about how to build an inclusive learning environment from the beginning by selecting people and strategies that do not carry the weight of the traditional academic model and its prejudices and assumptions about who belongs and who does not. This article documents the lessons learned in the first two years of a new college and presents some next steps.
Strategic Planning to Advance Equity on Campus: A Case Study at Portland State University
Authors: Zapata Marisa , Percy Stephen , Andrews Sona Karentz
Published: February 2018

Propelled by many factors, including a newly appointed Board of Trustees responsible for governance of our university, resource shortages, and enrollment swings, Portland State University embarked on a strategic planning effort in 2014 with the intent of reunifying a divided campus and creating a bold vision for moving forward in the next five years. While committed from the start to goals of diversity and inclusion, the planning process itself generated greater awareness of and commitment to equity—a bolder vision of empowerment that creates a responsibility to understand and mitigate negative, but often unintended consequences of, campus decisions and action—particularly as they impact groups that have experienced institutional racism and injustice. Equity emerged not only as a goal, with intendant initiatives for action, but also as a commitment to conscientious ongoing attention to decision-making that embraces utilization of an equity lens.
Open mesh repair, is still a standard technique for incisional hernia: a comparision study between sublay and onlay technique in the era of laparoscopy
Authors: Lamani Yamanur P. , Halbhavi Subhash N. , Goudar Bheemangowda V. , Kalaburgi Eshwar B. , Y. C. Veerabhadra Gowd
Published: February 2018

Background: Incisional hernia (IH) remains a very frequent postoperative complication and common hernias in middle aged population more commonly in females. The two techniques most frequently used are the onlay repair and sublay repair. Various studies have been conducted to compare the advantages and disadvantages of sublay and onlay mesh repair in incisional hernia and the superiority of sublay mesh repair. These studies whether they hold good for the population is a pertinent question. In view of this, author need to study the appropriate surgical techniques sublay versus onlay repair in the set up.Methods: Author conducted randomized comparative study of 100 patients having incisional hernia admitted to various surgical units of SNMC and HSK Hospital, Bagalkot during the period December 2014 to June 2016.Results: In present study of 100 cases, females have more incidence of incisional hernias than males. In onlay technique seroma formation was found in 72% of patients postoperatively and 4% in sublay technique. Surgical site infection (SSIN) was noticed in 8% of sublay technique whereas 12% in onlay technique. There is no recurrence in sublay group whereas onlay had 12% recurrence.Conclusions: Sublay technique is superior to onlay concerning the hospital stay, complications and recurrence.
Spiritual Authenticity in a Secular Context: How Modern Postural Yoga is Searching for Legitimacy in All the Wrong Places
Authors: Lindsay Kelly
Published: February 2018

This paper examines the historical origins and spiritual context of contemporary yoga practice in the West. In an attempt to assess the spiritual significance of this somatic practice, this essay explores the way in which both critics and promoters of postural yoga frame their arguments for the value of contemporary yoga practice by showing either its disconnect from, or homogeneity with ancient Hindu traditions. By tracing the evolution of yogic practice from its scriptural origins to its contemporary manifestations, this paper argues that yoga has never been a static or perfectly defined entity. Rather, yogic practice has a long history of being re-interpreted to meet the specific spiritual needs of practitioners. Modern Postural Yoga (MPY) represents a continuation of this tradition of adaptation. Rather than being an inadequate replication of an ancient tradition, I argue that MPY is a distinctly modern practice that has been transformed to fit the contemporary spiritual needs of a secularizing and body-conscious Western society.
Acknowledgements
Authors: Raptis Helen
Published: February 2018

Acknowledgements 2017
Office Automation for Industrial Business (AUTO ME)
Authors: Surana Priya , Karbhari Pooja , Rathod Pooja , Sawant Smita , Vibhute Madhura
Published: February 2018

Automation plays very important role in our lives. It makes the work easier and simpler so for simplified and easy living. Government of India has proposed Digital India campaign. Making this campaign successful involves reducing conventional methods used by small scale industry. Contributing to this campaign we are proposing a solution for business industry to reduce their paper work. The proposed system will provide database management for employee details. Along with this other modules of the system includes prediction algorithm for predicting site details depending on customer needs. The concept of Office Automation system provides advantage of no data duplication, data prediction and easy data backup with a user friendly interface. Overall project is divided into four modules and these modules can be accessed by admin and supervisor. Admin is authorized to log in and add details worker, client, vendor and also allowed to view the database and update the worker details.
Ameliyat sonrası hastane kökenli yara miyazisi
Authors: AZAR Ramazan , SARIGÖZ Talha , SEVİM Yusuf , TOPUZ Ömer , ERTAN Tamer
Published: February 2018

Miyazis doku ve organlarda konakçının mukoza, ölü doku veya vücut sıvılarından beslenen difteröz larvaların oluşturduğu parazitik enfestasyon olarak tanımlanır. Ülkemizde bu tür olgulara nadir rastlanmaktadır. Bu olguda divertikülit nedeni ile opere edilen erkek hastanın açık yarasında gelişen miyazis tartışıldı. Nazokomiyal miyazis hastanede yatan hastalarda meydana gelen nadir bir klinik durumdur. Hastalığa zemin hazırlayan faktörlerden yoğun bakım ünitelerinin dış çevre ile olan teması, kişisel hijyen, ameliyathanelerin izolasyonu, yara bakımı gibi faktörlerin iyileştirilmesi hastalığın insidansını azaltacaktır.
A case of bilateral Sertoli cell adenoma in androgen insensitivity syndrome
Authors: Öztürk İnal Zeynep , Gergerlioğlu Nursadan , Küçükosmanoğlu İlknur , Karanis Meryem İlkay
Published: February 2018

Androgen insensitivity syndrome, previously referred to as testicular feminization syndrome, is an X-linked recessive disorder that is characterized by a mutation in the q11-q12 region of the X chromosome, which results in a deformed androgen receptor gene. Patients with androgen insensitivity syndrome may develop testicular tumors, especially seminomas after puberty. A 35-year-old female patient presented with the complaint of primary amenorrhea and had masses of approximately 4 cm size palpated in the bilateral inguinal regions. The masses were excised and the histopathological examination was reported as bilateral Sertoli cell adenoma. Although the risk of bilateral gonadal tumor development is low in patients with androgen insensitivity syndrome, such malignancies should not be disregarded.
Dual Antiplatelet Therapy (DAPT) in Coronary Artery Disease: A Daunting Dilemma
Authors: Chaturvedula Suryateja , Diver Daniel J. , Vashist Aseem
Published: February 2018

Percutaneous coronary intervention(PCI) with stenting for the treatment of acute coronary syndrome(ACS) is the contemporary standard of care. Such treatment is followed by Dual anti-platelet therapy(DAPT) comprising of aspirin and a P2Y12 inhibitor. The efficacy of this therapy has been well established but the optimal duration of DAPT remains elusive, and has thus far attracted a prodigious deal of scientific attention. Decision regarding DAPT duration can be challenging clinically in the modern era with the evolution of newer stents, more potent antiplatelet agents and novel anticoagulant drugs in addition to an older patient population with multiple comorbidities. Major societal guidelines have emphasized comprehensive assessment of ischemic and bleeding risk, in turn recommending individualization of DAPT duration, thus encouraging "shared decision making". The following review is aimed at critically evaluating the available evidence to help make these crucial clinical decisions regarding duration of DAPT and triple therapy.
Unstable C1 Fracture Managed with Internal Fixation Using Lateral Mass Screws
Authors: Yu Jonathan C. , Niemeier Thomas E. , Manoharan Sakthivel R.
Published: February 2018

Case:

A 47-year-old woman presented with an unstable C1 fracture after falling down several stairs. She was found to have a sagittal split fracture of the right C1 lateral mass extending into the posterior arch. The fracture was treated with a direct posterior osteosynthesis of C1 using lateral mass screws.

Conclusion:

Surgical management of unstable C1 fractures has traditionally involved posterior fusion of C1 to C2 or fusion from the occiput to C2. These fusion procedures can be quite functionally limiting. Recently, direct osteosynthesis of C1 has been shown to be an effective, motion-preserving alternative.
Isolated Medial Patellofemoral Ligament Reconstruction with Semitendinosus Tendon Allograft
Authors: Ridley Taylor J. , Macalena Jeffrey A. , Arendt Elizabeth A.
Published: February 2018

Background:

Medial patellofemoral ligament (MPFL) reconstruction is recommended to surgically stabilize the patella against excessive lateral patellar translation. It is currently the cornerstone of treatment for recurrent lateral patellar instability. The MPFL is often disrupted during acute patellar dislocations but may also be attenuated in the setting of recurrent lateral instability. Numerous techniques have been developed with the primary goal of restoring the static function of the MPFL in resisting lateral translation of the patella during early flexion of the knee. There are now numerous options for the surgical technique, fixation devices, and graft choice, with equal clinical results as long as key surgical principles are maintained
1
. This article provides a step-by-step description of our preferred technique as well as offering technical pearls and a review of patient outcomes.

Description:

The MPFL is reconstructed anatomically using a hamstring allograft or autograft with an ideal width of 4 to 5 mm. The graft is secured to the femur with an interference screw at its anatomic insertion point, which can be defined by radiographic or anatomic landmarks, is passed through the soft tissues between the capsule and the medial retinaculum/vastus medialis oblique muscles, and is secured to the superomedial patellar border.

Alternatives:

Nonoperative treatment of lateral patellar dislocations is associated with recurrent dislocation rates of 35% to 50%; surgical treatment for recurrent dislocations has afforded improved patient outcomes
2,3
. In general, there are 3 surgical options to restore the function of the MPFL. Historically, acute repair was thought to offer the MFPL a chance to “heal” and resume its function; however, the literature has failed to support this as a reliable option in the setting of lateral patellar instability
4
. Similarly, delayed tightening or imbrication of the MPFL in the setting of chronic laxity has not demonstrated worthwhile clinical results
5
. MPFL reconstruction with a graft, as described here, has provided the most consistent outcomes.

Rationale:

Isolated reconstruction of the MPFL is indicated for patients with a history consistent with recurrent lateral patellar instability and a physical examination demonstrating excessive lateral patellar translation. Patients with high-grade trochlear dysplasia and patella alta may be better treated with concomitant osseous procedures such as trochleoplasty or tibial tubercle osteotomy.
Challenging Behavior, Parental Conflict and Community Violence in Students with Aggressive Behavior
Authors: Valdés Cuervo Angel Alberto , Tánori Quintana Jesús , Carlos Martínez Ernesto Alonso , Wendlandt Amezaga Teodoro Rafael
Published: February 2018

The effects of the presence of challenging behavior problems, parental conflict and violence in the community were determined by the probability of occurrence of bullying behaviors in elementary students. 664 students participated in the study, of whom 80 (12.04%) were identified as aggressors. 80 students with no reports of attacks were later selected randomly for comparison. Using logistic regression, it was found that the variables studied manifest significant differences between the student groups with and without aggressive behavior toward peers (R2 = .39). Challenging behavior (OR = 7.83), parental conflict (OR = 3.77) and Community Violence (OR = 5.36) increase the probability of belonging to the group of aggressors. We conclude that it is necessary to analyze the bullying from an ecological framework that considers variables located in the contexts in which individuals interact.
Personality and Creativity: A Study in Spanish-Speaking Children
Authors: Krumm Gabriela , Lemos Viviana , Richaud María Cristina
Published: February 2018

This work aimed at studying the relationship between personality from the Big Five Personality model and creativity through different techniques (i.e., a paper and pencil task, and scales) and informants (i.e., the child and parents). We evaluated a sample of 359 Spanish-speaking school children of both genders, aged 9 to 13 years. Personality was assessed with the Argentine Questionnaire of children’s Personality (CAPI). Creativity was evaluated using the following instruments: The Torrance Test of Creative Thinking-Figural Form B; and the Creative Personality Scale (EPC). Pearson correlations and multiple linear regressions consistently showed that Neuroticism related negatively to creativity while competence has a positive relation. The results suggested that more creative children presented less vulnerability, irritability and psychological distress, eventually becoming more independent, competent and emotionally self-regulated in coping with environmental demands.
Dimensionality and Determinants of Self-Reported Cognitive Failures
Authors: Tirre William C.
Published: February 2018

This research examined the dimensionality and the correlates of self-reported cognitive failures.  The first goal was to determine what factors, in addition to a general one, are needed to explain self-reported cognitive failures.  To explore this issue, both Rasch measurement and confirmatory factor analysis were employed.  The second goal was to determine if cognitive failures might be predicted with personality factors, general cognitive ability, and the need for cognition. A sample of 552 USAF airmen responded to the Broadbent Cognitive Failures Questionnaire (CFQ), a Big-Five personality inventory, the Abstract Reasoning Test, the Speeded Cognitive Ability Test, and the Need for Cognition survey.  Both Rasch modeling and confirmatory factor analysis indicated that a single factor dominated CFQ responses.  Regression analysis showed that CFQ responses were predicted well by personality factors (R = .60).
The Recovery from Alcohol Consumption: Analysis of the Construct of Relapse
Authors: Reyes-Huerta Hugo E. , Vacio Ángeles , Pedroza Francisco , Salazar Martha , Martínez Kalina
Published: February 2018

Objective: A systematic review was conducted to identify definitions that facilitated the study of relapse as both behavioral pattern and process. Methods: The review was conducted following the PRISMA-P guidelines. Articles that met the following inclusion criteria were considered: (a) published in peerreviewed journals, (b) provided an explicit operational definition of relapse, (c) assessed relapse during or after a specific psychological or self-care group intervention, (d) focused on alcohol consumption, and (e) were published between 2000 and September 2016. Results: “Any drinking” was the most frequent outcome used to identify relapse, although other discrete outcomes were also considered. Nevertheless, none of the definitions operationalize the notion of the return to a problematic drinking pattern and/or the process of relapse. Conclusion: Problems related to any drinking definition are discussed and we propose the use of a composed index to study relapse.
Lindy Trinkaus Zagzebski teoria autorytetu poznawczego. O potrzebie ufania innym
Authors: Dobrzeniecki Marek
Published: February 2018

W artykule autor analizuje teorię autorytetu przedstawioną przez Trinkaus Zagzebski. Teoria ta podkreśla rolę zaufania w uzasadnianiu zdań, m.in. wskazując na ograniczenia stanowiska egoizmu poznawczego, dla którego ideałem jest sytuacja, w której podmiot, uzasadniając swe przekonania, polega tylko na własnych zdolnościach poznawczych. Trinkaus Zagzebski broni uniwersalizmu poznawczego, wg którego już sam fakt, że osoba x, głosi że p, jest prima facie racją za p. W tekście autor wskazuje na słabe punkty uniwersalizmu i konkluduje, że albo uznamy to stanowisko z jego konsekwentnym odrzuceniem tezy o równości podmiotów poznających, albo też mimo wszystko opowiemy się za egoizmem poznawczym. Autor uznaje przy tym, że amerykańska filozofka daje nam wskazówki, jak ulepszyć owo stanowisko, by nie prowadziło ono do twierdzeń sprzecznych z intuicją.
Sekularyzacja religii w twórczości Rainera Marii Rilkego i Gianniego Vattima
Authors: Kobyliński Andrzej
Published: February 2018

Głównym celem artykułu jest analiza fenomenu sekularyzacji w pismach Rainera Marii Rilkego i Gianniego Vattima oraz prezentacja etyki miłosierdzia, zbudowanej na fundamencie religii w wersji słabej, pozbawionej wymiaru nadnaturalnego. Wielu naukowców przyznaje, że w ostatnich latach nastąpiło załamanie paradygmatu sekularyzacji. Okazało się, że nowoczesność i współczesna rewolucja technologiczna nie muszą koniecznie prowadzić do nieuchronnej śmierci religii. Coraz częściej mówi się dzisiaj o desekularyzacji i powrocie religii w zmienionej formie. Najgłębsze znaczenie sekularyzacji dotyczy nie tyle słabnącej obecności religii w domenie publicznej, ile reinterpretacji prawd i symboli religijnych oraz narodzin nowej formy religii o charakterze immanentnym i czystohumanistycznym. Bardzo złożony fenomen sekularyzacji i desekularyzacji wymaga obecnie szeroko zakrojonych badań interdyscyplinarnych.
Direct Observation of Intermediate State(s) in the Mechanistic Investigation of Domain Specific Protein-Surfactant Interaction
Authors: Yadav Rajeev , Sengupta Bhaswati , Das Shyamashis , Sen Pratik
Published: February 2018

Introduction: Interaction of surfactants with proteins can decipher important information
regarding the stability and behavior of proteins. For multi-domain proteins, these interactions vary
domain wise and these details are crucial in understanding the contribution of different domains of
the protein in its overall activity.

Objective: The objective of the present work is to study the interaction of surfactants with domain
III of Human Serum Albumin (HSA) and to compare the same with the global interaction.

Methods: Interaction of the anionic Sodium Dodecyl Sulphate (SDS) and the Cationic
Cetyltrimethylammonium Bromide (CTAB) surfactants with domain III of Human Serum Albumin
(HSA) has been studied using 8-Anilino-1-Naphthalene-Sulphonate (ANS) as a fluorescent marker.
Circular Dichroism (CD) spectroscopy has been used to study the protein-surfactant interaction for
the overall protein.

Results: SDS is found to interact sequentially with domain III of HSA having two detectable intermediate
states in the binding process. In case of CTAB, we have observed only one intermediate
state for its interaction with domain III. Although Quantum yield measurement can reflect the presence
of such intermediate state, the overall conformational change of the HSA on addition of surfactants,
studied by Circular Dichroism (CD) spectroscopy, and the ANS-Trp distance measurement
by FRET could not resolve the presence of such intermediate states. The esterase activity of
HSA in presence of different amount of surfactants is also in accordance with our above observation.

Conclusion: The interaction of both the surfactants with HSA is found to be sequential in nature.
The most important conclusion revealed from our study is that the nature of protein-surfactant interaction
is not same throughout the entire protein. Our study reveals that different parts of the
multi-domain HSA have different affinity to the surfactant molecules.
Monitoring Interactions Inside Cells by Advanced Spectroscopies: Overview of Copper Transporters and Cisplatin
Authors: Lasorsa Alessia , Natile Giovanni , Rosato Antonio , Tadini-Buoninsegni Francesco , Arnesano Fabio
Published: February 2018

Background:

Resistance, either at the onset of the treatment or developed after
an initial positive response, is a major limitation of antitumor therapy. In the case of platinum-
based drugs, copper transporters have been found to interfere with drug trafficking
by facilitating the import or favoring the platinum export and inactivation.

Methods:

The use of powerful spectroscopic, spectrometric and computational methods
has allowed a deep structural insight into the mode of interaction of platinum drugs with
the metal-binding domains of the transporter proteins.

Results:

This review article focuses on the mode in which platinum drugs can compete
with copper ion for binding to transport proteins and consequent structural and biological
effects. Three types of transporters are discussed in detail: copper transporter 1 (Ctr1), the
major responsible for Cu+ uptake; antioxidant-1 copper chaperone (Atox1), responsible
for copper transfer within the cytoplasm; and copper ATPases (ATP7A/B), responsible
for copper export into specific subcellular compartments and outside the cell.

Conclusion:

The body of knowledge summarized in this review can help in shaping current
chemotherapy to optimize the efficacy of platinum drugs (particularly in relation to
resistance) and to mitigate adverse effects on copper metabolism.
Pharmacoinformatics and Molecular Docking Studies Reveal Potential Novel Compounds Against Schizophrenia by Target SYN II
Authors: Tahir Rana Adnan , Sehgal Sheikh Arslan
Published: February 2018

Background:

Synapsin II regulates neurotransmitter release from mature nerve terminals
and plays important role in the formation of new nerve terminals. The associations of SYN II are
identified in various studies that are linked to the onset of Schizophrenia. Schizophrenia is characterized
by abnormal behavior like obsession, dampening of emotions and auditory hallucination.

Methods:

The bioinformatics approaches were utilized for structural modeling and docking analyses
of SYN II followed by pharmacophore generation to identify potent inhibitors.

Results:

The comparative modeling approach was employed to generate the 3D model having
82.404% quality factor calculated by Errat. Pharmacophore was constructed by utilizing merge
molecular and chemical features of selected five FDA approved Schizophrenia drugs by
LigandScout 4.1.5. Comparative docking analyses were performed by utilizing the selected drugs
and top screened hits by GOLD and AutoDock Vina.

Conclusion:

It was proposed that Aripiprazole drug and scrutinized compounds have strong binding
affinities among the other selected drugs. The reported compounds may be used for further analyses
in the drug discovery processes, as they have shown good human intestinal absorption and are noncarcinogenic.
The present study provides the structural insights which may be used for further
understating of the Schizophrenia therapeutic purposes by targeting SYN II and other inhibitors
haunting.
A Colorimetric Sensor for Dopamine Detection Based on Peroxidase-like Activity of Ce2(MoO4)3 Nanoplates
Authors: Rahimi-Nasrabadi Mehdi , Hosseini Morteza , Keihan Amir Homayoun , Ganjali Mohammad Reza
Published: February 2018

Introduction:

Artificial enzyme mimics are materials with similar catalytic function of natural
enzymes. Among several types of artificial enzymes, nanomaterial-based products or nanozymes
have been of particular interest to researchers.

Materials and Methods:

In this work, Ce2(MoO4)3 nanoplates were synthesized via a one-pot hydrothermal
approach. SEM and EDS characterizations show a plated-like architecture with high purity.
These nanoplates are shown to have an intrinsic peroxidase-mimetic activity. In the presence of H2O2,
Ce2(MoO4)3 nanoplates could catalyse the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) with high
performance to produce a blue dye (with an absorbance maximum at 652 nm). Dopamine (DA) has
some reducibility due to the phenol hydroxyl group, which results in using H2O2 and causing the blue
shallowing of the reaction solution by inhibiting the reaction between H2O2 and TMB. Based on that, a
visual, sensitive and simple colorimetric method using Ce2(MoO4)3 nanoplates as peroxidase mimics
was developed for detecting DA.

Results and Conclusions:

Suitable linear relationship for DA was obtained from 0.1 to 10 µM. The
limit of detection (LOD) of the proposed method was calculated as 0.05 µM and the relative standard
deviation (RSD) was less than 4.0%. The proposed method was successfully applied to DA detection in
human serum sample.
CHUNILAL MADIYA’S LILUDI DHARATI: A NARRATIVE CENTRED ON SAURASHTRA REGION
Authors: Chaudhari Bhagvanhai H.
Published: February 2018

As the inheritor of Jhaverchand Meghani, Madiya has narrated the old districts of Saurashtra (Sorath, mid-part of Saurashtra and Halar Region). Liludi Dharti is considered his ambitious Janpadi (of Rural Life) novel. It is his experiment based novel in which he has combined together the individual and group life to narrate the story of Sorathi life. Gundasar, a village located in the lap of the Girnar mountain of Junagadh in Saurashtra region is at the centre of the novel. The novelist aims at depicting realistic portrayal of rural culture. The event occurred in mistake develops the pitiful situation. The poverty of rural culture, their sexual desire, enmity, envy and conspiracy against each other show its genuine expression in context to the entire set-up. The writer employs the local dialects of Saurashtra region in its indigenous form. As he himself is the soul of that land, hence could efficiently utilize the local colours.
COMPARATIVE EFFECTIVENESS OF MODULAR AND E-LECTURE APPROACHES FOR LEARNING EDUCATIONAL RESEARCH CONCEPTS BY P.G. AND POST P.G. STUDENTS
Authors: Mudasir Sultan , K. Tyagi S.
Published: February 2018

Himachal Pradesh, due to its tourist destinations has been one of the top tourist places in India. For that matter, the number of domestic and international tourist’s visits is increasing from time to time. Looking at this potential of Himachal Tourism many people are venturing into the field of hotel business. This study was conducted to assess customer satisfaction with HPTDC hotels in Himachal Pradesh. To keep the customers happy it is important to understand the Expectations and experiences. The responses of the customers were taken for the purpose of analysis. It was found that though the staff is hospitable, the hotels are neat and comfortable, the taste of food is good and some services such as credit card facility is available in the hotels still efficiency in service, variety of food items, price of food and beverage, the landscaping, spaciousness of rooms and value for money are some burning issues which demand immediate attention by the HPTDC
“DEMONETIZATION” ROLL OUT FOR ECONOMIC DEVELOPMENT IN INDIA: A REVIEW
Authors: Sindhura K.
Published: February 2018

Demonetization was rolled out in India to bring change in the national currency. The author has reviewed various articles to capture the experience of the roll out. Prime Minister of India Mr. Narendra Modi stated that it was done for economic development of India. On 8th November 2016, the government announced the demonetization of Rs 500 and Rs 1000 bank notes. The execution and experience of common man had mixed feeling about the announcement. Various authors’ views are reviewed and summarized in this paper. Common man faced both positive and negative consequences. It is a reform for addressing corruption and various sectors faced challenges. Real estate, Hawala transactions, Black money, Terror Financing, Counterfeit currency, Non-East insurgency, Kashmir unrest, Terror financing, Maoism etc. were challenged by the reform. Banks played vital role in execution and had to face pressure from the public. It affected the common man with its sudden implementation, scarcity of lower denomination notes to replace the old notes, restriction on amount of withdrawal, prolonged shortage of smaller denomination etc.
Mobile Apps Use by Primary Care Patients to Manage Their Depressive Symptoms: A Qualitative Study (Preprint)
Authors: Pung Alison , Fletcher Susan Louise , Gunn Jane Maree
Published: February 2018

BACKGROUND

Mobile applications (apps) are emerging as tools with the potential to revolutionise the treatment of mental health conditions such as depression. At the forefront of community health sector, general practitioners (GPs) are in a unique position to guide the integration of technology and depression management, however little is currently known about how primary care patients with depressive symptoms are currently using apps.

OBJECTIVE

The aim of this study was to explore the natural patterns of mobile app use amongst patients with depressive symptoms, in order to facilitate understanding of the potential role for mobile apps in managing depressive symptoms in the community.

METHODS

Semi-structured phone interviews were conducted with primary care patients in Victoria, Australia, who reported symptoms of depression and were enrolled in a larger randomized controlled trial of depression care. Interviews explored current depression management strategies and the use of mobile apps (if any). Interviews were audio-recorded and transcribed verbatim. Inductive thematic analysis was iteratively conducted using QSR NVivo 11 Pro to identify emergent themes.

RESULTS

A total of 16 participants aged between 20 to 58 years took part in the interviews, with 11 reporting the use of at least one mobile app to manage depressive symptoms and 5 reporting no app use. A variety of apps were described including relaxation, mindfulness, cognitive, exercise, gaming, social media and wellbeing apps to aid with depressive symptoms. Amongst users, there were four main patterns of app use: skill acquisition, social connectedness, inquisitive trial, and safety netting. Factors that influenced app use included accessibility, perceptions of technology and personal compatibility. Healthcare providers also had a role in initiating app use.

CONCLUSIONS

Mobile apps are being utilised for self-management of depressive symptoms by primary care patients. This study provided insight into the natural patterns and perspectives of app use, which enhances understanding of how this technology may be integrated into the toolbox for the management of depression.