bluuebunny/crossref_metadata_2025 huggingface dataset:
First evaluation of the performance of portable IGRA, QIAreach® QuantiFERON®-TB in intermediate TB incidence setting
Authors: Aziz Zirwatul Adilah , Noordin Noorliza Mohamad , Wan Mohd Wan Mazlina , Kasim Mohd Amin
Published: February 2023

Diagnosis and treatment of tuberculosis infection (TBI) are the core elements of tuberculosis elimination. Interferon gamma release assays have advantages over the tuberculin skin test, although their implementation in low-resource settings is challenging. The performance of a novel digital lateral flow assay QIAreach® QuantiFERON®-TB (QIAreach QFT) against the QuantiFERON®-TB Gold Plus (QFT-Plus) assay was evaluated in an intermediate incidence setting (Malaysia) according to the manufacturer’s instructions. Individuals aged 4–82 years, who were candidates for TB infection screening for contact investigation were prospectively recruited. On 196 samples, the QIAreach-QFT showed a positive percent agreement (sensitivity) was 96.5% (CI 87.9–99.6%), a negative percent agreement (specificity) 94.2% (CI 88.4% to 97.6%) and an overall percentage of agreement was 94.9% (95% CI 90.6–97.6%) with a Cohen’s κ of 0,88. Out of 196, 5.6% (11/196) samples gave an error result on QIAreach-QFT and 4.1% (8/196) samples gave indeterminate result on QFT-plus. The TTR for QIAreach QFT positive samples varied from 210–1200 seconds (20 min) and significantly correlated with IFN-γ level of QFT-Plus. QIAreach QFT could be considered an accurate and reliable point-of-need test to diagnose TB infection helping to achieve the WHO End TB programme goals even in decentralised settings where laboratory expertise and infrastructure may be limited.
Neoadjuvant chemotherapy modulates exhaustion of T cells in breast cancer patients
Authors: Rodríguez Ivon Johanna , Bernal-Estévez David A. , Llano-León Manuela , Bonilla Carlos Eduardo , Parra-López Carlos Alberto
Published: February 2023

Breast cancer is the leading cause of cancer deaths in women worldwide. It has been observed that the incidence of breast cancer increases linearly with age after 45, which suggest a link between cancer, aging, and senescence. A growing body of evidence indicates that the immunosuppressive tumor network in breast cancer patients can lead to T-cell exhaustion and senescence. Cytotoxic chemotherapy is a common treatment for many cancers, and it is hypothesized that its efficacy may be related to immune activation. However, the effects of neoadjuvant chemotherapy on T-cell dysfunction in breast cancer patients are not fully understood. This study aimed to evaluate the impact of neoadjuvant chemotherapy on the expression of exhaustion and senescence markers in T cells in women with breast cancer. Our results showed that T cells from breast cancer patients have a reduced ability to respond to stimulation in-vitro and an increased expression of senescence and exhaustion-associated markers, such as TIM-3, LAG3, and CD57. Furthermore, we found that neoadjuvant chemotherapy has an immunomodulatory effect and reduces the expression of exhaustion markers. Our observations of the immune phenotype of T cells during neoadjuvant chemotherapy treatment highlight its ability to stimulate the immune system against cancer. Therefore, monitoring the response of T cells during chemotherapy may enable early prediction of clinical response.
Clinical and pharmacological factors associated with mortality in patients with COVID-19 in a high complexity hospital in Manaus: A retrospective study
Authors: Badin Rebeka Caribé , Amorim Robson Luís Oliveira de , Aguila Alian , Manaças Liliane Rosa Alves
Published: February 2023

COVID-19 is a contagious infection caused by the SARS-CoV-2 virus, responsible for more than 5 million deaths worldwide, and has been a significant challenge for healthcare systems worldwide. Characterized by multiple manifestations, the most common symptoms are fever, cough, anosmia, ageusia, and myalgia. However, several organs can be affected in more severe cases, causing encephalitis, myocarditis, respiratory distress, hypercoagulable state, pulmonary embolism, and stroke. Despite efforts to identify appropriate clinical protocols for its management, there are still no fully effective therapies to prevent patient death. The objective of this study was to describe the demographic, clinical, and pharmacotherapeutic management characteristics employed in patients hospitalized for diagnosis of COVID-19, in addition to identifying predictive factors for mortality. This is a single-center, retrospective cohort study carried out in a reference hospital belonging to the Brazilian public health system, in Manaus, from March 2020 to July 2021. Data were obtained from analyzing medical records, physical and electronic forms, medical prescriptions, and antimicrobial use authorization forms. During the study period, 530 patients were included, 51.70% male, with a mean age of 58.74 ± 15.91 years. The overall mortality rate was 23.58%. The variables age, number of comorbidities, admission to the ICU, length of stay, oxygen saturation, serum aspartate transaminase, and use of mechanical ventilation showed a positive correlation with the mortality rate. Regarding pharmacological management, 88.49% of patients used corticosteroids, 86.79% used antimicrobials, 94.15% used anticoagulant therapy, and 3.77% used immunotherapy. Interestingly, two specific classes of antibiotics showed a positive correlation with the mortality rate: penicillins and glycopeptides. After multivariate logistic regression analysis, age, number of comorbidities, need for mechanical ventilation, length of hospital stay, and penicillin or glycopeptide antibiotics use were associated with mortality (AUC = 0.958).
Remote follow-up based on patient-reported outcomes in patients with chronic kidney disease: A qualitative study of patient perspectives
Authors: Grove Birgith Engelst , Valen Schougaard Liv Marit , Ivarsen Per , Hjollund Niels Henrik , de Thurah Annette , Mejdahl Caroline Trillingsgaard
Published: February 2023

Background

Patient-reported outcomes (PROs) are increasingly used in outpatient follow-up. PRO-based remote follow-up offers a new healthcare delivery model, where PROs are used as the basis for outpatient follow-up in patients with chronic kidney disease. However, the patient’s perspective of this novel remote care delivery remains unknown.

Objectives

This study aimed to explore the patients’ experiences using PROs in remote care and how this mode of follow-up may enhance patient engagement.

Design

A qualitative approach was employed, guided by Focused Ethnography and Interpretive Description.

Participants

Purposively, 15 patients with chronic kidney disease experienced with PRO-based remote follow-up in 3 renal outpatient clinics in the Central Denmark Region, were recruited.

Measures

Field studies comprising participant observation in remote PRO consultations and individual, semi-structured interviews with the patients constituted the empirical data. Thematic analysis was performed according to Braun and Clarke’s six-phase process.

Results

PRO-based remote follow-up may enhance patient engagement by a) improving communication, b) increasing disease knowledge, c) inducing flexibility, d) ensuring clinician feedback on PRO data, and e) prompting clinical action. Barriers to enhanced patient engagement were identified as a) lack of feedback on PRO data, b) lower disease knowledge, c) PRO in competition with biomedical data, and d) loss of personal relation.

Conclusion

PRO-based follow-up in remote care holds several advantages for the patients. However, some barriers need clinical awareness before PROs may enhance the patients’ engagement in remote follow-up. Future studies should explore the impact of involving relatives in PRO-based follow-up.
Gallbladder microbiota in healthy dogs and dogs with mucocele formation
Authors: Gookin Jody L. , Hartley Ashley N. , Aicher Kathleen M. , Mathews Kyle G. , Cullen Rachel , Cullen John M. , Callahan Benjamin J. , Stowe Devorah M. , Seiler Gabriela S. , Jacob Megan E. , Arnold Jason W. , Azcarate-Peril M. Andrea , Stauffer Stephen H.
Published: February 2023

To date studies have not investigated the culture-independent microbiome of bile from dogs, a species where aseptic collection of bile under ultrasound guidance is somewhat routine. Despite frequent collection of bile for culture-based diagnosis of bacterial cholecystitis, it is unknown whether bile from healthy dogs harbors uncultivable bacteria or a core microbiota. The answer to this question is critical to understanding the pathogenesis of biliary infection and as a baseline to exploration of other biliary diseases in dogs where uncultivable bacteria could play a pathogenic role. A pressing example of such a disease would be gallbladder mucocele formation in dogs. This prevalent and deadly condition is characterized by excessive secretion of abnormal mucus by the gallbladder epithelium that can eventually lead to rupture of the gallbladder or obstruction of bile flow. The cause of mucocele formation is unknown as is whether uncultivable, and therefore unrecognized, bacteria play any systematic role in pathogenesis. In this study we applied next-generation 16S rRNA gene sequencing to identify the culture-negative bacterial community of gallbladder bile from healthy dogs and gallbladder mucus from dogs with mucocele formation. Integral to our study was the use of 2 separate DNA isolations on each sample using different extraction methods and sequencing of negative control samples enabling recognition and curation of contaminating sequences. Microbiota findings were validated by simultaneous culture-based identification, cytological examination of bile, and fluorescence in-situ hybridization (FISH) performed on gallbladder mucosa. Using culture-dependent, cytological, FISH, and 16S rRNA sequencing approaches, results of our study do not support existence of a core microbiome in the bile of healthy dogs or gallbladder mucus from dogs with mucocele formation. Our findings further document how contaminating sequences can significantly contribute to the results of sequencing analysis when performed on samples with low bacterial biomass.
A UVR-sensor wearable device intervention to reduce sun exposure in melanoma survivors: Results from a randomized controlled trial
Authors: Vogel Rachel Isaksson , Luo Xianghua , Brown Katherine , Jewett Patricia , Dona Allison C. , Nagler Rebekah H. , Ahmed Rehana L. , Martinson Brian C. , Lazovich DeAnn
Published: February 2023

Background

Melanoma survivors are at increased risk of developing a second primary melanoma; however, some report sub-optimal sun behaviors and sunburns. We tested the effectiveness of a wearable device with ultraviolet radiation (UVR)-sensing technology to improve sun behaviors and reduce sunburns in cutaneous melanoma survivors.

Materials and methods

We conducted a randomized controlled trial using Shade 2, a commercially available wrist device that measures UVR. The intervention group received the device and mobile application notifications about their exposure and prompts to use sunscreen. The control group received the device and a separate research mobile application without information about their exposure or notifications. Participants wore the device for 12 weeks and self-reported sun behaviors before, during, and after the intervention. The primary outcome was a composite score of sun protection behaviors at week 12.

Results

386 participants were randomized (186 control, 182 intervention). Most were female and 5+ years past their first melanoma diagnosis. The average age was 56 years. Most (93%) completed the study, though 40% experienced device issues. No meaningful differences were observed in self-reported sun protection behaviors at week 12 (controls 3.0±0.5 vs. intervention 2.9±0.5, p = 0.06), any sunburn during the intervention period (controls 14.4% vs. intervention 12.7%, p = 0.75), or average daily objective UVR exposure (controls median 87 vs. intervention 83 J/m2, p = 0.43).

Conclusion

Wearing a device that measured and alerted melanoma survivors to UVR exposure did not result in different sun behaviors, exposure, or sunburns relative to controls. The technology needs refinement before further attempts to assess the effectiveness of self-monitoring UVR exposure.

Clinical trials registration

NCT03927742.
Learning high-order interactions for polygenic risk prediction
Authors: Massi Michela C. , Franco Nicola R. , Manzoni Andrea , Paganoni Anna Maria , Park Hanla A. , Hoffmeister Michael , Brenner Hermann , Chang-Claude Jenny , Ieva Francesca , Zunino Paolo
Published: February 2023

Within the framework of precision medicine, the stratification of individual genetic susceptibility based on inherited DNA variation has paramount relevance. However, one of the most relevant pitfalls of traditional Polygenic Risk Scores (PRS) approaches is their inability to model complex high-order non-linear SNP-SNP interactions and their effect on the phenotype (e.g. epistasis). Indeed, they incur in a computational challenge as the number of possible interactions grows exponentially with the number of SNPs considered, affecting the statistical reliability of the model parameters as well. In this work, we address this issue by proposing a novel PRS approach, called High-order Interactions-aware Polygenic Risk Score (hiPRS), that incorporates high-order interactions in modeling polygenic risk. The latter combines an interaction search routine based on frequent itemsets mining and a novel interaction selection algorithm based on Mutual Information, to construct a simple and interpretable weighted model of user-specified dimensionality that can predict a given binary phenotype. Compared to traditional PRSs methods, hiPRS does not rely on GWAS summary statistics nor any external information. Moreover, hiPRS differs from Machine Learning-based approaches that can include complex interactions in that it provides a readable and interpretable model and it is able to control overfitting, even on small samples. In the present work we demonstrate through a comprehensive simulation study the superior performance of hiPRS w.r.t. state of the art methods, both in terms of scoring performance and interpretability of the resulting model. We also test hiPRS against small sample size, class imbalance and the presence of noise, showcasing its robustness to extreme experimental settings. Finally, we apply hiPRS to a case study on real data from DACHS cohort, defining an interaction-aware scoring model to predict mortality of stage II-III Colon-Rectal Cancer patients treated with oxaliplatin.
Spatial memory distortions for the shapes of walked paths occur in violation of physically experienced geometry
Authors: Du Yu K. , McAvan Andrew S. , Zheng Jingyi , Ekstrom Arne D.
Published: February 2023

An important question regards the nature of our spatial memories for the paths that we have walked and, in particular, whether such distortions might violate the topological properties of the shape of the paths (i.e., creating an intersection when two paths did not intersect or vice versa). To investigate whether and how this might occur, we tested humans in situations in which they walked simple paths and idiothetic and visual cues either matched or mismatched, with the mismatching cues creating the greatest potential for topological distortions. Participants walked four-segment paths with 90° turns in immersive virtual reality and pointed to their start location when they arrived at the end of the path. In paths with a crossing, when the intersection was not presented, participants pointed to a novel start location suggesting a topological distortion involving non-crossed paths. In paths without a crossing, when a false intersection was presented, participants pointed to a novel start location suggesting a topological distortion involving crossed paths. In paths without crossings and without false intersections, participants showed reduced pointing errors that typically did not involve topological distortions. Distortions more generally, as indicated by pointing errors to the start location, were significantly reduced for walked paths involving primarily idiothetic cues with limited visual cues; conversely, distortions were significantly increased when idiothetic cues were diminished and navigation relied primarily on visual cues. Our findings suggest that our spatial memories for walked paths sometimes involve topological distortions, particularly when resolving the competition between idiothetic and visual cues.
Hipoacusia neurosensorial bilateral infantil postCovid
Authors: Almeida-Ayerve Cristina Nicole , Marcos-Alonso Susana , Fernández-Nava María José , Peña-Navarro Paula , Monópoli-Roca Chiara , Calvo-Boizas Enrique
Published: February 2023

Introducción: Durante la pandemia por SARS-CoV-2 y después de la fase aguda, se han descrito síntomas persistentes como secuela. En área ORL se han descrito principalmente odinofagia, disfonía y acúfenos. La hipoacusia no está actualmente en la lista de síntomas pre o post COVID-19. Sin embargo, se han descrito algunos casos alrededor del mundo de hipoacusia neurosensorial sobre todo semanas después de superar la infección.

Caso clínico: Paciente varón de 8 años sin antecedentes, quien en marzo del 2020 acudió a urgencias por broncoespasmo relacionado con infección de vías respiratorias altas. Varios meses después presentó sensación subjetiva de hipoacusia, ante sospecha de Otitis media serosa se pautó tratamiento con corticoide intranasal. En octubre del 2020 lo derivan a la consulta de ORL por persistencia de la hipoacusia con otoscopia normal bilateral. En Audiometría Tonal Liminal (ATL) presentó hipoacusia neurosensorial bilateral moderada con curvas A bilaterales en impedanciometria.

Evolución: Durante el seguimiento, se confirmó la hipoacusia bilateral descrita en Potenciales Evocados Auditivos de Estado Estable (PEAEE). En el estudio etiológico y debido a la fecha de inicio de los síntomas (inicio de la pandemia COVID-19), se añadió serología con anticuerpos para SARS COV 2 siendo estos positivos; el paciente no se encontraba vacunado y ninguno de los padres referían el antecedente dicha infección. 

Conclusiones: La pérdida auditiva, total o parcial, no está actualmente en la lista de síntomas COVID-19 agudo ni en COVID persistente, además de que no hay suficiente evidencia para relacionar este síntoma como secuela de dicha infección. Se necesitan estudios de alta calidad para determinar los riesgos a largo plazo a nivel cócleo-vestibular.
Képek a Kádár-korszakról
Authors: Medgyesi Konstantin
Published: February 2023

A tanulmányban azt vizsgáljuk, hogy a rendszerváltozás után
évtizedekkel milyen társadalmi-kulturális folyamatoknak köszönhetően
alakulhatott ki egyfajta posztmodern reneszánsza a Kádár-korszakot
illusztráló fotóknak. Úgy véljük, az Enyedi-gyűjtemény újrapozícionálásához
szükséges szociológiai előfeltétel volt az, hogy a puha diktatúra alatt
fiatal korosztályok, a ma nyugdíjasai elfoglalták helyüket napjaink
közösségi médiatérében.
A susceptibilidade geoambiental da bacia hidrográfica do Ribeirão Lajeado - Tocantins
Authors: Ribeiro Lucas Silva , Robaina Luís Eduardo Souza , Cristo Sandro Sidnei Vargas
Published: February 2023

O estudo geoambiental através da integração dos elementos naturais com o uso e a cobertura da terra é uma proposta metodológica para o planejamento estratégico. Nesse sentido, o objetivo deste artigo é realizar uma análise da susceptibilidade geoambiental, a partir do uso de análise multicritério, na bacia hidrográfica do Ribeirão Lajeado. Para isso, realizou-se a organização de materiais cartográficos: rede de drenagem, a declividade, a litologia, os solos, o uso e a cobertura da terra e as vias de acesso. Foram estabelecidos pesos normalizados a partir da técnica do processo analítico hierárquico (AHP). Esse cruzamento gerou o mapa de susceptibilidade geoambiental, definida em quatro unidades, a saber: I) baixa (área de topo plano com cobertura vegetal e nenhuma proximidade com as vias acessos); II) média (locais com algumas ocupações humanas ou com relevo suave ondulado); III) alta (áreas onde apresentam ampla ocorrência de estradas e rede de drenagem abundante, susceptíveis à intervenção antrópica, relacionadas principalmente as atividades agropecuária e áreas urbanas) e IV) muito alta (locais com estradas e porções de uso agropecuário com declividades maiores que 15%, presença de cicatrizes de fogo e áreas urbanas. Assim, a técnica AHP apresenta-se como uma importante ferramenta para o geoambiental, principalmente na definição de pesos para os fatores analisados.
Kandungan Logam (Pb) pada Air, Sedimen, dan Jaringan Lunak Kerang Darah (Anadara granosa) di Perairan Bandengan, Kabupaten Kendal Serta Batas Aman Konsumsi untuk Manusia
Authors: Fernandes Arya , Santoso Adi , Widowati Ita
Published: February 2023

Kegiatan pembangunan industri yang berkembang cukup pesat di kawasan industri Kabupaten Kendal diduga menjadi penyebab meningkatnya limbah buangan industri yang didalamnya terkandung logam berat timbal (Pb), sehingga limbah tersebut berkontribusi menurunkan kualitas perairan Bandengan, Kabupaten Kendal. Penelitian ini dilakukan dengan tujuan untuk mengetahui kadar logam (Pb) pada air, sedimen, dan kerang darah (A. granosa) serta batas maksimal konsumsi mingguan kerang darah (A. granosa) yang mengandung logam timbal (Pb) di Perairan Bandengan, Kabupaten Kendal. Penelitian ini dilaksanakan pada bulan Maret dan April 2022. Metode penelitian yang digunakan yaitu metode deksriptif sedangkan penentuan lokasi penelitian dengan metode purposive sampling. Analisis konsentrasi logam berat Pb dilakukan di Laboratorium Balai Besar Teknologi Pencegahan Pencemaran Industri (BBTPPI) dengan metode AAS (Atomic Absorption Spectrophotometry), sedangkan untuk analisis batas aman konsumsi mingguan dihitung dengan MTI (Maximum Tolerable Intake). Hasil penelitian ditemukan konsentrasi logam Pb di perairan Bandengan sebesar <0,003 mg/l, sedimen berkisar 15,32-24,21 mg/kg, dan kerang darah berkisar 0,209-0,731 mg/kg. Berat maksimal mengkonsumsi kerang darah (A. granosa) perminggu dari perairan Bandengan, Kabupaten Kendal individu dengan berat badan 60 kg sebesar 2,051-7,177 kg/minggu. Sedangkan, individu dengan berat 45 kg yaitu 1,538-5,382 kg/minggu. Industrial development activities have been developing quite rapidly in the Kendal Regency industrial area and are suspected to be the cause of the increase in the waste containing lead (Pb) heavy metal. It might contribute to reducing the quality of Bandengan waters. This study was to know the levels of metal (Pb) in water, sediment, and blood cockles (A. granosa) and the maximum weekly consumption of the cockles containing lead (Pb) in the waters. The study conducted in March and April 2022 used the descriptive method and purposive sampling to determine the locations. Analysis of Pb concentration was at the Laboratory of the Center for Industrial Pollution Prevention Technology (BBTPPI) using the AAS (Atomic Absorption Spectrophotometry) method. The analysis of the safe limit for weekly consumption was using the formula of MTI (Maximum Tolerable Intake). The results showed that Pb concentrations in water, sediment, and tissue in Bandengan waters were <0.003 mg/l, 15.32 - 24.21 mg/kg, and 0.209 - 0.731 mg/kg, respectively. The maximum weight of consuming blood cockles (A. granosa) per week from Bandengan waters, Kendal Regency of 60 kg individuals weighing was 2,051 - 7,177 kg/week. Meanwhile, individuals weighing 45 kg were 1,538 - 5.382 kg/week.
Kesesuaian dan Daya Dukung Kawasan Wisata Pantai Tilalohe, Batudaa Pantai, Kabupaten Gorontalo
Authors: Panigoro Citra , Paramata Arfiani Rizki , Kasim Faizal , Akase Maharani Nurul Fadila
Published: February 2023

Memanfaatkan lahan dan sumber daya alam untuk tujuan ekowisata membutuhkan desain yang terkait dengan kesesuaian atraksi dan daya dukung wilayahnya. Penelitian ini bertujuan untuk menilai kesesuaian alokasi lahan kawasan dan daya dukungnya untuk kegiatan pariwisata di wilayah Pantai Tilalohe. Metode penelitian terdiri dari metode survei untuk kondisi bio-fisik dan penelitian literatur untuk karakteristik area pantai Tilalohe, serta kesesuaian dan daya dukung wilayah sebagai tujuan wisata. Hasilnya menunjukkan bahwa pantai Tilalohe secara geomorfologis memiliki karakteristik pantai saku. Jenis atraksi yang paling cocok adalah duduk dengan santai di semua stasiun pada lahan utama dengan luas 1315,45 m2 dengan garis pantai di sepanjang 114,84 m. Perairan di depan tanah utama, dengan luas 5965,20 m2 dan garis pantai 182,79 m, sangat mendukung pengunjung untuk kegiatan mandi dan berenang di wilayah timur. Studi ini menunjukkan peran penting analisis kesesuaian dan daya dukung untuk arahan peruntukan lahan untuk kegiatan ekowisata berdasarkan prinsip-prinsip perlindungan lingkungan dan keberlanjutan manfaat. Utilizing land and natural resources for ecotourism purposes requires a design related to the suitability of the attractions and its region's carrying capacity. This study aims to assess the suitability of the region's land allocation and its carrying capacity for tourism activities in the Tilalohe Beach area. The research method consists of survey methods for bio-physical conditions and literature research for the characteristics of the Tilalohe Beach area, as well as the suitability and carrying capacity of the region as a tourist destination. The results show that geomorphologically Tilalohe beach has characteristics of a pocket beach. The most suitable attraction is sitting casually at all stations on the main land with an area of 1315.45 m2 with coastlines along 114.84 m. This study shows an essential role of analysis of the suitability and carrying capacity of the area in the direction of land allotment for ecotourism activities based on the principles of environmental protection and the sustainability of benefits.
Uji Ekstrak Spons Laut Jenis Ptilocaulis marquezii dari Perairan Kendit sebagai Potensi Antibakteri Escherichia coli
Authors: Maisaroh Dian Sari , Al Hanif Yahya Abdillah , Munir Misbakhul , Sa'adah Nor
Published: February 2023

Guna mengetahui potensi bioaktivitas senyawa yang terkandung serta mengetahui uji ekstrak spons Ptilocaulis marquezii terhadap pertumbuhan bakteri Eschercia coli. Penelitian dilakukan secara eksperimen berupa uji ekstrak berupa pembuatan ekstrak spons Ptilocaulis marquezii dengan maserasi serta evaporasi dengan rotary vacuum evaporator pada suhu 40°C hingga ekstrak terbentuk. Dilakukan pengujian dengan metode Difusi cakram atau Kirby-Bauer test.  Pengujian fitokimia guna mengetahui kandungan senyawa aktif. Hasil yang diperoleh didapatkan ekstrak dengan konsentrasi 40% yang memiliki kemampuan sedang. Pada uji fitokimia mengandung alkoloid dan triptenoid. Ekstrak spons Ptilocaulis marquezii pada konsentrasi 40% dengan zona hambat sebesar 9.5 mm dalam kategori sedang dan pada konsentrasi lainnya yaitu 10%, 20%, 60% dan 80% berkategori lemah. Senyawa alkaloid menghambat pertumbuhan Escherichia Coli dengan merusak susunan peptidoglycan. Pada senyawa triterpenoid merusak membran plasma pada bakteri Escherichia coli.  Knowing the potential bioactivity of the compounds contained and knowing the test of the extract of the Ptilocaulis marquezii sponge of Eschercia coli bacteria. The research was carried out experimentally in the form of extract testing in the form of making Ptilocaulis marquezii sponge extract by maceration and evaporation with a rotary vacuum evaporator at a temperature of 40°C until the extract was formed. The test was carried out using the disc diffusion method or the Kirby-Bauer test. Phytochemical testing to determine the content of active compounds. The results obtained were extracts with a concentration of 40% which had moderate abilities. The phytochemical test contains alkaloids and triptenoids. Ptilocaulis marquezii sponge extract at a concentration of 40% with an inhibition zone of 9.5 mm in the medium category and at other concentrations of 10%, 20%, 60% and 80% in the weak category. Alkaloids inhibit the growth of Escherichia Coli by destroying the peptidoglycan structure. The triterpenoid compounds damage the plasma membrane of Escherichia coli bacteria.
Edukacyjne zróżnicowanie
Authors: Kwiatkowska-Ratajczak Maria
Published: February 2023

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Zastygłe w niepokoju? O doświadczaniu czasu w opowieści polskich więźniarek lagrów i łagrów
Authors: Kołodziejska Agnieszka
Published: February 2023

Doświadczenie lagrowe i łagrowe znane jest głównie i omawiane w polskiej szkole na podstawie narracji męskich (T. Borowski, G. Herling-Grudziński). Artykuł oparty jest na długo niedostrzeganych świadectwach kobiecych, które stanowią obszerny i konieczny do uwzględnienia materiał o wysokiej wartości źródłowo-informacyjnej i literackiej. Autorka rozważa jeden z elementów kobiecego doświadczenia obozowego, jakim jest odczuwanie czasu w stanie uwięzienia: zamknięcia w ograniczonej i pilnie strzeżonej przestrzeni niemieckiego obozu koncentracyjnego, sowieckiego więzienia oraz łagru położonego na bezkresach rosyjskiej Północy. Zastanawia się nad jednostkowym i wspólnotowym charakterem powyższych doświadczeń i ich literackiej reprezentacji, sytuując je w świetle refleksji K. Jaspersa, J. Leociaka oraz psychiatrów zajmujących się poobozową traumą.
Koiné i kontr-koiné, solidarność i jej antonimy – rozważania nad kulturową wspólnotą uczniowsko-nauczycielską na przykładzie cyklu prelekcji polonistycznych Otwartej Rzeczpospolitej „JAWNE KOMPLETY – lektury oddelegowane, lektury orzekające inaczej”
Authors: Kuczyńska-Koschany Katarzyna
Published: February 2023

W artykule mowa o cyklu prelekcji polonistycznych pod patronatem Otwartej Rzeczpospolitej „JAWNE KOMPLETY – lektury oddelegowane, lektury orzekające inaczej”, koordynowanych przez autorkę tekstu w roku szkolnym i akademickim 2021/2022 – w szerokim kontekście kulturowym, między innymi w kontekście kategorii koiné, wspólnoty i solidarności.
India in the Imagination of 20th and 21st Century Croatian Literature
Authors: Molvarec Lana
Published: February 2023

The purpose of this paper is to study perceptions of India in three literary works, from the 20th and 21st century. The first part looks into the tenets of postcolonial theory and literary imagology as a possible methodological framework. Subsequently, premodern perceptions of India in the Croatian literary and cultural space are summarised. The central analysis focuses on the historical novelJaša Dalmatin (Jaša Dalmatin, Viceroy of Gujarat) by Ivana Brlić-Mažuranić, the travelogue U potrazi za staklenim gradom (In Search of the Glass City) by Željko Malnar and Borna Bebek, and the short story Indija (India) by Bekim Sejranović. The analysis demonstrates that each of these writings reconstructs premodern perceptions to some extent, but primarily introduces new perceptions that are linked to the specific social, cultural and ideological context in which these works were written. This indicates that literary perceptions are at the same time always acts of literary fiction as well as a socially and culturally construed production of meaning.
A Carleman inequality on product manifolds and applications to rigidity problems
Authors: Sun Ao
Published: February 2023

In this article, we prove a Carleman inequality on a product manifold

M
×
R

M\times {\mathbb{R}}

. As applications, we prove that (1) a periodic harmonic function on

R

2

{{\mathbb{R}}}^{2}

that decays faster than all exponential rate in one direction must be constant 0, (2) a periodic minimal hypersurface in

R

3

{{\mathbb{R}}}^{3}

that has an end asymptotic to a hyperplane faster than all exponential rate in one direction must be a hyperplane, and (3) a periodic translator in

R

3

{{\mathbb{R}}}^{3}

that has an end asymptotic to a hyperplane faster than all exponential rates in one direction must be a translating hyperplane.
Exergy analyses of two and three stage cryogenic cycles
Authors: Atasbak Musa , Keven Arzu , Karaali Rabi
Published: February 2023

Cryogenics has an important influence on industry and science. In this study, optimum working conditions are obtained by applying exergy analysis and local optimization methods to two- and three-stage vapor compression cascade cryogenic cycle. The first and second laws of thermodynamics, exergy analysis, and local optimization methods are applied to the two- and three-stage cascade cryogenic cycle. By considering the needs and demands, it is possible to create new cycles by adding new devices and/or new stages to these cycles. The results of the optimum operating conditions are obtained for the two- and three-stage vapor compression cascade cryogenic cycle. It is seen that to achieve high COP values and high efficiency; it is necessary to reduce the compression ratio of the compressor as much as the fluid allows. For the two-stage cycle, the minimum total work required for cryogenic cooling is around P
7 = 2,400 kPa. The COP value is 0.30 between P
7 = 2,400 and 2,800 kPa, and the maximum exergy efficiency is obtained around 0.235. It is seen operating the first-stage compressor at high pressures increases the total losses of the entire cycle from 7,500 to 18,550 kW. The increase in total exergy losses is around 247%, and operating the first-stage compressor at high pressures increases the exergy efficiency of the entire cycle. The increase in total exergy efficiency is around 160%. When the second-stage compressor is operated at low pressure, the COP value increases by 2%, the exergy efficiency increases by 20%, and the exergy losses decrease by around 40%.
Data sharpening and linguistic theorizing: a case study of the causative derivation of Urdu change-of-state verbs
Authors: Sharif Ahmad Naveed
Published: February 2023

This study examines the evidential value of corpus and introspective data from the perspective of morphological operations involved in the causative derivation of Urdu change-of-state verbs. By analyzing multi-source data on the transitivity status of causative variants of 112 Urdu verbs, it discovers a crucial relation between the type of evidence and the aspect of linguistic competence it addresses. More specifically, it compares data from lexical translation, Urdu WordNet and Urdu Lughat on the one hand, and data from a judgment task coupled with dialogical introspection on the other hand, and finds that the former can reveal the gradient nature of morphological productivity, but not its dynamic nature; the latter, however, can help explore the dynamic nature of productivity in the causative alternation. Such an observation confirms that both corpus and introspection complement each other, and that a particular source-specific piece of evidence may limit the coverage and generality of analysis. Thus, the study shows the importance of sharpening data by multi-source evidence for examining how various components of a phenomenon interrelate in the context of the overall grammatical organization of a language.
Ukraine and singular optics
Authors: Berry Michael
Published: February 2023

The mostly theoretical viewpoint, in which light is understood in terms of its singularities – caustics, phase vortices and lines of circular and linear polarisation – was developed in Bristol in the 1970s and 1980s. Starting in the 1990s, research by physicists in Ukraine, principally by Marat Soskin, stimulated the development of ‘singular optics’ as a thriving area of experimental and theoretical physics worldwide.
Optimization of information acquisition security of broadband carrier communication based on linear equation
Authors: Peng Liye , Liu Qing , Lyu Xiaohua
Published: February 2023

In order to study the optimization of information acquisition security of broadband carrier communication and solve the problem of low baud rate of data acquisition in traditional communication operation data acquisition systems, this article reconstructs the required arrangement of communication operation data signals in the acquisition path by taking broadband carrier communication in the station area as an example through the linear equation method of genetic algorithm. The baud rate of the designed acquisition system is significantly higher than that of the control group, and the acquisition accuracy is 100% by using phase shift key modulation and high carrier frequency. It can solve the problem of low baud rate of data acquisition in traditional communication operation data acquisition systems and improve the security of information acquisition. The security (loss, anti-interference) of broadband carrier communication information collection based on the improved legacy algorithm is better than that of the traditional genetic algorithm, indicating that the security of broadband carrier communication information collection based on the improved legacy algorithm does not increase with the number of iterations and decrease.
Ἔν τινι εἶναι als Hintergrund der paulinischen Rede vom Sein ‚in Christus‘
Authors: Beyer Barbara
Published: February 2023

Paul’s ἐν Χριστῷ phrases have long caused much investigation among scholars, yet no consensus has been reached as to what they mean and how the apostle came to speak of the relationship between believers and Christ in this way. This brief survey shows that the philological background of Paul’s “being in Christ” phrases lies in the largely analogous Greek phrase ἔν τινι εἶναι which expresses dependency of something or someone on something or someone else. Various passages from the archaic up until the imperial period that have received no attention so far demonstrate this. In Paul, the concept of dependency in connection with ἐν Χριστῷ phrases particularly comes to play in Rom 1–8.
Bewertungsmodell zur proaktiven Produktionssteuerung im Schiffsbau
Authors: Janke Tim , Schäfer Niklas , Böttger Kathrin
Published: February 2023

Der Wettbewerbsdruck auf deutsche Werfen steigt durch ausländische Konkurrenz stetig. In der für den Spezialschiffsbau typischen Einzelfertigung liegen Kostenpotenziale insbesondere in der Verbesserung der Produktionssteuerung. Dazu wird in diesem Beitrag ein systematischer Ansatz zur proaktiven Produktionssteuerung im Schiffsbau vorgestellt, der Werften helfen soll, Entscheidungen datenbasiert zu treffen und somit Durchlaufzeiten und Kosten zu senken.
Johnson Resigns. What Next for the Tories?
Authors:   Institute of Europe, Russian Academy of Sciences, Ananieva Elena
Published: February 2023

Since November, the highest echelons of the Conservative Party have been involved in a series of scandals, which also affected PM B. Johnson. The ratings of the ruling party and head of the Cabinet began to decline rapidly, and the authority of B. Johnson as leader was questioned by the parliamentary faction and the public. The popularity of the Labour Party and its leader K. Starmer has risen amid the crisis in the ruling party. Despite B. Johnson winning the vote of confidence, his position became untenable and his resignation became a matter of not “if”, but “when”. Elections of the new Tory leader turned into an acute struggle disclosing deep divisions in the Conservative party. No matter who will be the next PM the UK government will be unable to reverse the economic situation and the cost of living crisis before the parliamentary elections in 2024. The UK foreign policy will mostly remain the same with no amelioration of UK-Russia relations and probable escalation on the China track. The Labour Party is leading in opinion polls on the background of the Tory crisis.
Recycling of Some Water Soluble Drugs for Corrosion Inhibition of Steel Materials: Analytical and Electrochemical Measurements
Authors:   Basic Science Department, Preparatory Year, University of Ha’il, 1560, Hail,  KSA, Abdel Hameed R. S. , Al-bonayan A. M. ,   Chemistry Department, Faculty of Science, Al- Azhar University,11884, Cairo,  Egypt,   Chemistry Department, Faculty of Science, Umm Al-Qura University, Makkah  Mukaramha, Saudi Arabia
Published: February 2023

The accumulation of the expired vitamin B6 drugs is hazards for both our child’s and environment, the present research aimed to reuse the expired water soluble drug in its pharmaceutical form as potential non-toxic corrosion inhibitor for steel alloys used in manufacturer of the petroleum pipe lines in 1.0 M HCl. Atomic absorption spectroscopy(AAS) and electrochemical techniques were used to evaluate the corrosion inhibition efficiency, effect of concentrations and temperature were studied, the data show that the inhibition efficiency was increased with concentrations and decreased with temperature. Potentiodynamic polarization data show that the expired vitamin B6 retard both anodic and cathodic potential meaning it is a mixed inhibitor. The electrochemical impedance spectroscopy EIS, techniques data shows that the expired drug help to increases the polarization resistance by adsorbing on metal/electrolyte interface. This kind of adsorption found to obeying Langmuir adsorption isotherm model. The data obtained from the used techniques exhibit good agreement between them with (± 1) to prove that the used expired vitaminB6 medicinal drugs act as eco-friendly corrosion inhibitor for the steel in acidic environment in its pharmaceutical from
Sol-gel Synthesis of Nanoscaled Spinels using 1, 2-ethanediol as a Gelation Agent
Authors:   Department of Physics, The Women University Multan, Pakistan., Rani M. , Tariq K. ,   Department of Physics,University of Agriculture Faisalabad, Pakistan, Younus A. ,   National Institute of Lasers & Optronics NILOP college PIEAS, Islamabad, Pakistan, Batool K. ,   Nuclear Institute of Agriculture and Biology NIAB Faislabad, Pakistan, Sattar M. ,   Bahauddin Zakariya University Multan, Pakistan, Shafique R. , Bukhari M. , Akhtar N. , Mehmood A.
Published: February 2023

In the present work sodium chromite (NaCr2O4) based pigment was synthesized using sol gel technique. From XRD analysis, it is clear that all samples manufactured by sol gel technique have spinel structure crystallization. Also chromites with a chromium concentration (max) shows black color and Na- substituted shows green color. The samples were annealed at different temperature from 600˚C to 700˚C. The obtained nano particles were characterized by other different techniques as well such as Scanning electron microscopy, Raman spectroscopy, Photoluminence and Energy dispersive spectroscopy. The particle size of parent compound is ranging from 4.4nm to 11nm determined from SEM. The tendency of particles to form the aggregates with the increasing annealing temperature has been observed. The optical characterization of the compound shows that the sol gel attained material is strongly persuasive sodium chromite.
SPTing across condensates: SEC‐mediated translocation of SPT complex from pausing condensates to elongation condensates
Authors: Rawat Prashant , Sawarkar Ritwick
Published: February 2023

Several independent studies in the last few years have suggested that phase separation and biomolecular condensation play a critical role in regulating different transcription steps from initiation to pausing and elongation. However, how components of the transcription machinery translocate among different types of condensates during transcription remains poorly understood. Guo et al have now identified a potential mechanism underlying translocation of the DSIF complex from pausing to elongation condensates during promoter pause release, as reported in this issue of EMBO reports.
Refletindo sobre finitude: um enfoque na assistência de enfermagem frente à terminalidade
Authors: de Medeiros Ylana Karine Fonseca , Bonfada Diego
Published: February 2023

Morrer e morte são experiências humanas universais que fazem parte do cotidiano das equipes de enfermagem. Neste estudo, objetivou-se analisar as implicações das concepções dos profissionais de enfermagem sobre a morte e o morrer na assistência prestada ao paciente terminal da Unidade de Terapia Intensiva geral de um hospital referência em oncologia no Estado do Rio Grande do Norte, Brasil. A coleta de dados se deu no período de junho a agosto de 2010 por meio de observação livre e entrevistas semi-estruturadas, tendo sido entrevistados 11 profissionais de enfermagem. Para análise dos dados escolheu-se o método de Análise Temática. Os resultados obtidos apontaram para uma multiplicidade de sentimentos e dimensões conceituais relativas ao processo de morte como determinantes das ações de cuidado aos pacientes terminais. Concluiu-se evidenciando a necessidade de estratégias transformadoras dessa realidade que contribuam para a melhoria da qualidade da assistência de enfermagem ao paciente terminal e seus familiares.
Fatores de risco da doença coronariana em pacientes que realizaram revascularização miocárdica
Authors: Teixeira Lima Francisca Elisângela , Araújo Thelma Leite de , Oliveira Lopes Marcos Vinícius de , da Silva Lucia de Fatima , Monteiro Ana Ruth Macedo , de Oliveira Sherida Karanini Paz
Published: February 2023

O objetivo foi verificar a frequência dos fatores de risco da doença coronariana em pacientes que realizaram revascularização do miocárdio. Estudo descritivo, desenvolvido no ambulatório de um hospital público, referência em cardiologia, Fortaleza-Ceará, Brasil. A amostra foi composta por 78 pacientes que se submeteram à cirurgia de revascularização do miocárdio. Os dados foram coletados nos prontuários e por avaliações do paciente na alta hospitalar. Os fatores de risco para doença arterial coronariana avaliados foram: hipertensão arterial (83,3%), diabetes (46,2%), dislipidemia (46,2%), obesidade (67,9%), sedentarismo (57,7%) e tabagismo (34,6%). Conclui-se que a hipertensão arterial, a obesidade e o sedentarismo foram os fatores de risco mais frequentes nos pacientes que realizaram revascularização do miorcárdio e que a maior parte deles apresentou no mínimo três fatores de risco.
O cuidado cotidiano da criança na perspectiva Winnicottiana
Authors: Mello Débora Falleiros de , Antonietto Ana Carolina Gomes , Carvalho Furtado Maria Cândida de , Wernet Monika , Alves Juliana de Jesus
Published: February 2023

O presente estudo tem como objetivo descrever o modo como o cuidado cotidiano de crianças menores de dois anos é visto pelas mães, fornecendo subsídios às práticas e saberes em saúde da criança no contexto da atenção primária de saúde. Trata-se de estudo descritivo-exploratório com análise qualitativa dos dados, na perspectiva da abordagem Winnicottiana, a partir de entrevistas gravadas com 17 mães. Os resultados estão organizados nos temas: responsabilidade materna e o cuidado da criança; cuidar da criança e do seu ambiente; conforto e interação na família. Foi possível apreender significados das experiências cotidianas, discutidos à luz dos conceitos Winnicottianos: mãe suficientemente boa, holding, ambiente facilitador e espaço transicional. Conhecer o cotidiano quanto ao cuidado materno é importante para os profissionais de saúde na busca de suporte às mães e famílias, amenizar ansiedades, avaliar problemas no ambiente de cuidado da criança, disponibilizando uma assistência qualificada e humanizada.
Perfil de usuários masculinos atendidos em um serviço de referência para doenças sexualmente transmissíveis
Authors: Souza Adriano Rodrigues de , Freitas Ana Paula Chaves de , Rovere Giselle Pereira , Moura Ana Débora Assis , Feitoza Aline Rodrigues
Published: February 2023

Objetivou-se traçar o perfil epidemiológico dos usuários masculinos portadores de doenças sexualmente transmissíveis, atendidos em um Centro Especializado nessas enfermidades, em Fortaleza-CE, Brasil. Estudo do tipo exploratório, com abordagem quantitativa, realizado em outubro de 2008, com 137 prontuários de pacientes atendidos em 2007. Utilizou-se um formulário de pesquisa com dados socioeconômicos e clínicos. Detectou-se que 95,6% residiam em Fortaleza; 51% chegaram por demanda espontânea; 49,6% tinham de 20 a 29 anos; 46% referiram ter 10 ou mais anos de estudo; a orla marítima apareceu com a maior incidência dos casos; 65% tiveram de uma a cinco consultas; apenas 4% fizeram uso de algum medicamento; e 57,7% tiveram a verruga genital como principal diagnóstico. Concluiu-se que o perfil traçado revelou homens jovens, na sua maioria com o Ensino Médio concluído, moradores de bairros pobres.