bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of wooden floorboards on the vibration of timber floor
Authors: Hassan Osama
Published: September 2023

This study is aimed at investigating those parameters related to timber flooring that can affect the acceptability of vibration behaviour of a timber floor in a residential building in view of the criteria stated in Eurocode EC5. The timber floor investigated is made of OSB/3 floorboards and timber joists. The parameters that are investigated in this study are thickness of flooring, floor joist span, joist spacing and connection of floorboards to the joists. In this context, two cases are considered. First: the flooring is nailed or screwed to the joists and no composite action or interaction is obtained between joists and floorboards. Second: the flooring is glued sufficiently to the joists and full interaction is obtained. The result suggests that glued floorboards perform much better with respect to natural frequency, static deflection and peak floor velocity than nailed or screwed floorboards. In almost all cases of glued floorboards, the result complies fully with the Eurocode 5 design vibration requirements. However, as floor lengths increase, the static deflection will increase beyond the allowable limit, especially for relatively thin floor panels and relatively widely spread joists. For both cases, increasing floorboards thickness and decreasing the joist span by adding more beams can yield even better results to satisfy the requirement of vibration comfort.
The Chain Mediating Effect of Socialist Core Values and Positive Psychological Capital on Relationship Between Meaning in Life and Crisis Vulnerability
Authors: LIU Qin , CHANG Renjie , Peng Junjie
Published: September 2023

Objective: To explore the relationship between the sense of meaning in life and crisis vulnerability of undergraduate nursing student and the chain mediating effect of socialist core value identification and positive psychological capital on the relationship between the two.
Methods: A total of 330 undergraduate nursing students (M±SD = 19.68±1.31 years old) from traditional Chinese medicine colleges in Yunnan ethnic minority areas were measured bythe Sense of Life Scale, Socialist Core Values Identity Scale, Sense of Life Scale and Crisis Vulnerability Questionnaire.
Results: The sense of meaning in life was negatively correlated with crisis vulnerability, positively correlated with socialist core values identification and positive psychological capital, negatively correlated with crisis vulnerability, positively correlated with socialist core values identification and positive psychological capital, and positively correlated with socialist core values identification. The chain mediation effect analysis shows that the sense of meaning in life can predict crisis vulnerability through three indirect pathways: the mediating effect of socialist core value identification, the mediating effect of positive psychological capital, and the chain mediating effect of socialist core values and positive psychological capital.
Conclusion: The sense of meaning in life may be a remote variable of the crisis vulnerability of undergraduate nursing students, which can reduce individual crisis vulnerability by enhancing the level of socialist core value identification and positive psychological capital.
GPR-RF: A Network Attack Traffic Detection Method Based on Random Forest and Bayesian Optimization
Authors: Du Xiaoyu , Lin Lvzhou , Han Zhijie , Zhang Changtao , Du Ying
Published: September 2023

Intrusion detection systems can identify intrusion processes which are attempting to intrude, in the process of intruding, or have already occurred.Intrusion detection is a proactive defense approach. Intrusion detection system models built by machine learning are very sensitive to hyper-parameter settings, and different combinations of hyper-parameters can dramatically affect the model's capabilities. In previous work, finding hyperparameters corresponding to advanced models is a difficult task. In order to deal with the huge amount of network traffic data, we here propose the Gaussian Process Regression and Random Forest (GPR-RF) method, which uses Bayesian optimization of Gaussian process regression to find more appropriate combinations of Random Forest hyperparameters, and realizes the following two advantages: 1. The accuracy of the model is greatly improved compared to the traditional methods. 2. The method can quickly converge to better configurations. Among several methods compared, our method performs best in both aspects.
Onion (Allium cepa L.) flavonoids extract ameliorates osteoporosis facilitating osteoblast proliferation and differentiation, and inhibiting RANKL-induced osteoclastogenesis
Authors: Zhang Danyang , Wang Xiaoyu , Sun Kezhuo , Guo Jianli , Zhao Jia , Dong Yuesheng , Bao Yongming
Published: September 2023

Osteoporosis, a bone metabolic disease, is a global chronic health problem. Flavonoids, a group of natural active compounds widely existing in vegetables, fruits, beans and cereals, were reported to be anti-osteoporosis. Onion is a common vegetable rich in flavonoids. In this study, bone mineral density (BMD) was increased significantly after taking onion flavonoids extract (OFE) orally in an ovariectomized (OVX)-induced rat model, the trabecular structure and serum biomarkers were both improved, with effects similar to estradiol. Compared with the OVX rats, the contents of E2, calcium and phosphorus in the serum of rats were enhanced, but ALP and Trap levels in serum were decreased. In addition, the activity of on bone health was assessed by human osteoblast-like cells MG-63 and osteoclast precursor Raw 264.7 cells in vitro as well. After treated with OFE, MG-63 cells proliferation and mineralization were promoted, and alkaline phosphatase (ALP) activity and mRNA expression of OPG/RANKL were increased significantly. Moreover, RANKL-induced osteoclastogenesis of Raw 264.7 cells and osteoclast activity were inhibited with decrease of tartrate-resistant acid phosphatase (TRAP) activity, and mRNA expression of remarkable enzymes was down-regulated in cells. Furthermore, it was demonstrated that OFE regulated activity of osteoblast mainly via the OPG/RANKL signaling pathway and osteoclastogenesis. The results provided evidence a new model of dietary supplements for preventing osteoporosis.
IL-12/IFN-γ axis drives skin wound healing via innate defense mechanisms against bacterial invasion in teleost fish
Authors: Qiu Xingyang , Yang Mu , Sun Hao , Liu Jiaxi , Wang Xinyan , Zhang Anying , Yang Kun , Zhou Hong
Published: September 2023

Objective and design
IL-12 is a well-recognized pro-inflammatory cytokine with multi-functions in participating mammalian innate immunity, but little is known regarding the details for protecting skin barrier damage in lower vertebrates. The aim of this study was to evaluate the effects and mechanisms of IL-12 and its key effectors in promoting skin wound repair in teleosts.
Material or subjects
Recombinant gcIL-12BB (rgcIL-12BB) was employed to investigate IL-12 roles in teleost skin wound healing. Meanwhile, the regulatory effects of rgcIL-12BB on re-epithelialization, inflammation and bacterial clearance at lesion sites were explored. Furthermore, the role of increased IFN-γ and recruited neutrophil in skin wound were uncovered. Finally, the mechanism of neutrophil bacterial clearance triggered by IFN-γ was also elucidated.
Results
The rgcIL-12BB could promote wound healing, reduce bacterial invasion, and significantly promote epithelial cell proliferation and migration. Moreover, as the main effector of IL-12BB, IFN-γ was observed to exhibit bactericidal activities mainly via recruiting and stimulating autophagic neutrophils in teleosts. In line with findings in mammals, the grass carp guanylate-binding protein 1 (gcGBP1) acts as a downstream effector of the IL-12/IFN-γ axis that interacts with autophagy-related proteins LC3B and P62, which are involved in gcIFN-γ-induced autophagy.
Conclusion
Collectively, our results highlighted an intrinsic mechanism whereby the IL-12/IFN-γ axis triggers the host's innate defense against bacterial infection, thereby improving skin wound healing in teleosts.
3D printing technology combined with personalized customization of steel plates for the treatment of complex distal intra-articular fractures of the trimalleolar ankle
Authors: Liang Hairui , Zhang He , Chen Beibei , Yang Lei , Xu Rongda , Duan Siyu , Cai Zhencun
Published: September 2023

This study investigated the effectiveness of 3D printing technology in combination with personalized custom-made steel plates in the treatment of complex distal intra-articular trimalleolar fractures, with the aim of providing a new approach to improve ankle joint function in patients. The 48 patients with complex distal intra-articular tri-malleolar fractures included in the study were randomly divided into two groups: the personalized custom-made steel plate group (n = 24) and the conventional steel plate group (n = 24). A comparison was made between the two groups in terms of preoperative preparation time, hospitalization duration, surgical time, fracture reduction and internal fixation time, intraoperative fluoroscopy instances, surgical incision length, fracture healing time, follow-up duration, degree of fracture reduction, ankle joint functional recovery, and the occurrence of complications. The personalized steel plate group exhibited longer preoperative preparation time and hospitalization duration compared to the conventional steel plate group (p < 0.001). However, the personalized steel plate group demonstrated significantly shorter surgical duration, time for fracture reduction and internal fixation, reduced intraoperative fluoroscopy frequency, and a shorter overall surgical incision length (p < 0.001). Both groups displayed similar fracture healing times and follow-up durations (p > 0.05). The personalized steel plate group showed a higher rate of successful fracture reduction (87.5% vs. 79.2%, p > 0.05) and a lower incidence of complications (8.3% vs. 20.8%, p = 0.22), although these differences did not reach statistical significance. Furthermore, the personalized steel plate group exhibited superior ankle joint function scores during follow-up compared to the conventional steel plate group (p < 0.05). By utilizing 3D printing technology in conjunction with personalized custom-made steel plates, personalized treatment plans are provided for patients with complex comminuted tri-malleolar ankle fractures, enabling safer, more efficient, and satisfactory orthopedic surgeries.
Ferulic acid alleviates inflammatory manifestations in atopic dermatitis through modulation of the TRPV1/HMGB1 signaling pathway
Authors: Wang Hui-Min , Lee Yi-Chieh , Chen Chung-Yi , Chang Jui-Jen , Hung Huei-Cheng , Tsai Pei-Chien
Published: September 2023

Atopic dermatitis (AD) is a prevalent skin ailment in Asia, and the currently available clinical interventions provide only limited respite while potentially leading to undesired or severe side effects. This investigation explores ferulic acid's potential as an innovative and efficacious remedy for AD. Ferulic acid, recognized for its diverse pharmacological and biological attributes, underwent evaluation through both cellular and in vivo studies. The outcomes revealed that ferulic acid adeptly mitigated the inflammatory retort associated with AD by quelling the activation of the TRPV1 and HMGB1 signaling pathways—both tied to the Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) and High Mobility Group Protein 1 (HMGB1). In a BALB/c mouse model, ferulic acid demonstrated significant amelioration of AD symptoms prompted by DNCB, including the reduction of skin barrier impairment, diminished ear and skin epidermal thickness, curbed mast cell infiltration, and decreased spleen and lymph node dimensions. These findings underscore the potential of ferulic acid as a viable treatment avenue for AD. The multifaceted attributes of ferulic acid, its confirmed pharmacological and biological merits, and its demonstrated effectiveness in assuaging AD's inflammatory responses, as validated by cellular and in vivo investigations, collectively propose its significant promise as a compelling substitute in the therapeutic landscape for AD. Running head: Ferulic acid inhibits inflammation in AD
Electrospinning of poly(ethylene oxide)/glass hybrid nanofibers for anticounterfeiting encoding
Authors: El-Newehy Mohamed H. , Aldalbahi Ali , Thamer Badr M. , Abdulhameed Meera Moydeen
Published: September 2023

The use of photochromism to increase the credibility of consumer goods has shown great promise. In order to provide mechanically dependable anticounterfeiting nanofibers, it has also been critical to improve the engineering processes of authentication patterns. Mechanically robust and photoluminescent electrospun poly(ethylene oxide)/glass (PGLS) nanofibers (150-350 nm) integrated with nanoparticles of lanthanide-doped aluminate (NLA; 8-15 nm) were developed using electrospinning technology for anti-counterfeiting purposes. The provided nanofibrous films change color from transparent to green when illuminated with ultraviolet light. By delivering NLA with homogeneous distribution without aggregations, we were able to keep the nanofibrous film transparent. When excited at 365 nm, the NLA@PGLS nanofibers displayed emission intensity at 517 nm. The hydrophobicity of NLA@PGLS nanofibers was improved by raising the pigment concentration. After being triggered by ultraviolet light, NLA@PGLS showed quick and reversible photochromism without fatigue. It has been shown that the suggested method can be applied to reliably produce a variety of anti-counterfeiting materials.
Landscape Naturalness Scenarios Modeling for the Juréia-Itatins Protected Areas Mosaic, State of São Paulo, Brazil
Authors: Guilhem Andres Caseiro , Fushita Angela Terumi , Francisco Richard Fonseca
Published: September 2023

Due to its biodiversity, ecosystem services offered, and deforestation experienced since the 16th century, there are several protected areas in Atlantic Forest, such as the Juréia-Itatins Protected Areas Mosaic (JIPAM), state of São Paulo, Brazil. Illegal deforestation in the JIPAM and surroundings have been increasing, caused by urban and agricultural expansion. Landscape naturalness scenarios of JIPAM and surroundings for 2050 year were simulated, considering the periods 1985–2002 and 2002–2019, which correspond, respectively, to the scenarios before and after the creation of the JIPAM and National System of Protected Areas (NSPA). The landscape naturalness was evaluated by generating Distance to Nature index (D2N) maps for years 1985, 2002 and 2019, which was used as input data in simulation. The forecasting of both scenarios was conducted using cellular automata, weights of evidence and Markov chain, in Dinamica EGO platform. Both projections indicated that there would be a slight decrease in landscape naturalness. However, the scenario with JIPAM and NSPA can be considered the most effective in guiding the study area toward a conservation profile, as it would contribute to a reduction of approximately 32% of non-natural areas located within mosaic, in relation to another scenario. The NSPA and the creation of the JIPAM have contributed to maintain the study area naturalness, reducing losses in landscape naturalness. Nevertheless, municipal planning and the JIPAM management plans should consider urban and agricultural expansion and access roads as important drivers of loss of landscape naturalness, triggering deforestation and biodiversity damages.
New Water-Stainless Steel Rod-Plate Heat Pipe: Model and Experiments
Authors: Araújo Elvis Falcão , Mera Juan Pablo Flóres , Cisterna Luis H. R. , Mantelli Márcia Barbosa Henriques
Published: September 2023

This work proposes a novel flat heat pipe technology, namely the rod-plate heat pipe, formed by the diffusion bonding of a set of parallel rods, of around 8 mm diameter, between flat plates of approximately 500 x 60 x 2 mm3. This design is inspired by the mini wire-plate heat pipe concept. This work is the first in the literature to apply this technology to large size heat pipes. A theoretical model is devised and used to predict the fluid distribution along the heat pipe, detect regions of flooding and dry-out and determine the best charging volume. Experiments are performed with a stainless-steel device operating in horizontal orientation with water as working fluid. Electrical cartridge resistances play the role of the evaporator heat source, while the condenser is cooled by either natural convection or heat exchangers linked to a thermal bath. The thermal resistances of the water charged device cooled by natural convection are very low, with a minimum of 0.046 ºC/W, for 88.59 W for heat input. Moreover, the operation temperature increases with heat input up to 326.56 ºC for a heat load of 191.40 W. The thermal resistances of the heat pipe cooled by the heat exchanger are also very low, with a minimum of 0.144 ºC/W at 177.49 W heat transport rate, for a 50 ºC thermal bath temperature. The theoretical results and data obtained so far corroborate the feasibility of this technology, with devices able to transfer up to 22.71 W per groove.
In situ polymerization of hydrogel electrolyte on electrode enabling the flexible all-hydrogel supercapacitors with low-temperature adaptability
Authors: Zhang Yijing , Sun Yue , Nan Jingya , Yang Fusheng , Wang Zihao , Li Yuxi , Wang Chuchu , Chu Fuxiang , Liu Yupeng , Wang Chunpeng
Published: September 2023

All-hydrogel supercapacitors are emerging as promising power sources for next-generation wearable electronics due to their intrinsically mechanical flexibility, eco-friendliness, and enhanced safety. However, the insufficient interfacial adhesion between electrode and electrolyte and the frozen hydrogel matrices at subzero temperatures largely limit the practical applications of all-hydrogel supercapacitors. Here, we report an all-hydrogel supercapacitor with robust interfacial contact and anti-freezing property, which is fabricated by in situ polymerizing hydrogel electrolyte onto hydrogel electrode. The robust interfacial adhesion is developed by the synergistic effect of tough hydrogel matrix and topological entanglements. Meanwhile, the incorporation of ZnCl2 in the hydrogel electrolyte prevents water solvents from freezing and endows the all-hydrogel supercapacitor with mechanical flexibility and fatigue resistance across a wide temperature range of 20°C to − 60°C. Such all-hydrogel supercapacitor demonstrates satisfactory low-temperature electrochemical performance, delivering high energy density of 11 mWh cm–2 and excellent cycling stability with capacitance retention of 99% over 5000 cycles at − 40°C. Notably, the fabricated all-hydrogel supercapacitor can endure dynamic deformations and operate well under 2000 tension cycles even at − 40°C, without delamination and electrochemical failure. This work offers a promising strategy for flexible energy storage devices with low-temperature adaptability.
Deep Learning Model for Automated Detection and Classification of Central Canal and Neural Foraminal Stenosis at Cervical Spine MRI
Authors: Zhang Enlong , Yao Meiyi , Li Yuan , Wang Qizheng , Song Xinhang , Chen Yongye , Liu Ke , Zhao Weili , Xing Xiaoying , Zhou Yan , Meng Fanyu , Ouyang Hanqiang , Chen Gongwei , Jiang Liang , Lang Ning , Jiang Shuqiang , Yuan Huishu
Published: September 2023

Objectives: Developing a Deep learning (DL) model to automatically detect and classify cervical canal and neural foraminal stenosis on cervical spine MRI can improve the accuracy and efficiency of its diagnostic.
Methods: A method for cervical spinal stenosis was proposed based on the DL model, consisting of region of interest (ROI) detection and cascade prediction. First, three part-specific convolutional neural networks were used to detect the ROIs in different parts of cervical MRI images. Then, the cascade prediction of stenosis categories was performed to obtain the results of stenosis level and position on each slice of the patients. Finally, in the testing, the results were fused to obtain a patient-level diagnostic report. The performance was evaluated with the metrics of accuracy (ACC), area under curve (AUC), sensitivity, specificity, F1 Score, and diagnosis time of the DL model, as well as recall rate for ROI detection localization.
Results: The average recall rate of ROIs localization reached 89.3% (neural foramen), and 99.7% (central canal) under the five-fold cross-validation of our DL model. In dichotomous classification (normal or mild vs moderate or severe), ACC and AUC of the DL model were very close to the level of radiologists, and the F1 score (84.8%) of the DL model was slightly higher than that of radiologists (83.8%) at central canal.
Conclusion: The DL model showed comparable performance with subspecialist radiologists for detection and classification of the central canal and neural foraminal stenosis at cervical spine MRI with significant time-saving.
The pattern of gene expression (IGF family, muscle growth regulatory factors and osteogenesis related genes) involved in growth of skeletal muscle in pikeperch (Sander lucioperca) during ontogenesis
Authors: Lavajoo Fatemeh , Falahatkar Bahram , Perelló-Amorós Miquel , Moshayedi Fatemeh , Efatpanah Iraj , Gutiérrez Joaquim
Published: September 2023

The pikeperch (Sander lucioperca) is an economically important freshwater fish and a valuable food with high market acceptance. It is undergoing important changes in growth and regulatory metabolism during the ontogeny. Hence, the current study aims to investigate the mRNA expression of the growth hormone (gh)/insuline-like growth factor (igf) axis (ghr, igfI, igfbp, igfr), muscle regulatory factors (pax7, myf5, myod, myogenin, mrf, mymk, mstn) and osteogenesis related genes (colla1a, fib1a, on, op, ostn) from hatching through day 40th post hatching (DPH). The average total length (TL) of larvae measured at hatching was 3.6 ± 0.4 mm (67 degree-day) and at the end of experiment (40 DPH, 777 degree-day) was 27.1 ± 1.1 mm. The results showed three phases of gene expression in the egg, larval and juvenile stages of pikeperch ontogenesis. The expression pattern of fib1a and muscle gene myf5 showed the highest value at the egg stage. The growth hormone receptor gene (ghr), mymk and mstnb, raised to 1 DPH, whereas the expression of igf1rb and igf1bp5 was increased from 1 to 14 DPH. Increased expression of igfI, igfII, igf1bp4 and mrf4 was detected after 10 and 14 DPH. The myod1 expression raised at 8, 14 and 21 DPH. Differently myod2 showed only a large transient downregulation at 3 DPH and juvenile stage. The six genes igf1ra, pax7, myogenin, col1a1a, on, and ostc were highly expressed at 21 DPH and juvenile stage. Results from this study suggest that basal metabolism, growth of body cells, muscle and bone proliferation and development can be regulated by the dynamic changes in gene expression patterns in this species. The identified genes will help to understand the basic biological process of pikeperch larvae, and development, which is very important in pikeperch farming.
Dynastic Measures of Intergenerational Mobility
Authors: Bargain Olivier B. , Bue Maria C. Lo , Palmisano Flaviana
Published: September 2023

We suggest a simple and exible criterion to assess relative inter-generational mobility. It accommodates different types of outcomes, such as (continuous) earnings or(discrete and ordinal) education levels, and captures dynastic improvements of such outcomes at different points of the initial distribution. We provide dominance characterizations - for instance on the relative progress made by women vs. men - that areconsistent with social preferences upon desirable patterns of mobility. We suggest an application on Indonesia. Using the IFLS data, we match parents observed in 1993 totheir children in 2014, providing one of the rare intergenerational mobility analyses based on a long panel in the context of a developing country. Results indicate that mobility in terms of education and potential earnings was markedly at the advantage of women. The bulk of the population came out of illiteracy, possibly due to large scale education reforms, but the relative educational mobility was regressive, which considerably reduced the progressivity of mobility in terms of potential earnings.
JEL classification: J6, J62, O12.
A New Lightweight Authentication for Internet of Drones
Authors: Wang Shuhuan , Wang Yimin
Published: September 2023

As an important branch of the Internet of Things, Internet of Drones (loD) is changing the way of human life. However, loD suffer cyber attacks in practice. In 2021, Hussain et al. proposed an loD authentication scheme based on Elliptic Curve Cryptography (ECC) to solve this problem. Through analysis, their scheme is expensive to calculate and difficult to adapt to loD environment. As a result, a new lightweight authentication scheme based on secure one-way hash function and bitewise XOR operations was proposed. The experimental results show that the proposed scheme not only guarantees the safety, but also has lower computation cost. Thus, it is more suitable for loD.
Evaluation of the predictive capability of Response surface methodology (RSM) and Adaptive neuro-fuzzy inference system (ANFIS) in estimating biogas yield from poultry droppings, pig manure & brewery spent grain using enzyme amylase
Authors: Onyiah Maxwell Ikemefuna , Gordian O. Mbah , Ude Callistus Nonso , Ude Michael Uzobuenyi
Published: September 2023

One of the biggest obstacles investigators face is predicting biogas yield, which is an enormous challenge because study in the field of simulation and optimization of biogas yield is still restricted, particularly with the adaptive neuro-fuzzy inference system (ANFIS). This study aims to develop and compare models that best predict the oxygen-independent decomposition of poultry droppings, pig manure and brewery spent grain for biogas production with the influence of enzyme amylase. The Response surface modelling (RSM) and a hybrid algorithm, Adaptive Neuro Fuzzy Inference System (ANFIS), was evaluated by considering temperature, residence duration, enzyme concentration, and pH as independent variables, while biogas generation served as the response or output factor. Relevant statistical metrics like AAD, MAE, RMSE and \({R}^{2}\) were applied to relate the adequacy of the two models. The performance of both RSM and ANFIS were compared based on the performance metrics. The calculated value of the coefficient of determination (\({R}^{2})\) for the biogas yield by implementing RSM using the enzyme amylase gave (\({R}_{PD}^{2}=0.9974, {R}_{PM}^{2}=0.9910 \& {R}_{BSG}^{2}=0.9975)\). This was compared with ANFIS results with an \({R}^{2}\) value of \(( {R}_{PD}^{2}=0.9986, {{R}_{PM}^{2}=0.9985 \& R}_{BSG}^{2}=0.9985).\) Analysis of the RSM and ANFIS results shows that the ANFIS prediction result is statistically marginal and presents the hybrid algorithm as a better prediction and optimization tool.
Comparison between continued inpatient treatment versus day patient treatment after short inpatient care in early onset anorexia nervosa (COTIDEA trial): a study protocol for a non- inferiority randomised controlled trial
Authors: Ayrolles Anaël , Bargiacchi A. , Clarke J. , Michel M. , Baillin F. , Trebossen V. , Kalifa H. Poncet , Guilemin-Crépon S. , Delorme R. , Godart N. , Stordeur C.
Published: September 2023

Background: In children with early-onset anorexia nervosa (first symptoms before 13 years old, EO-AN), experts recommend initial outpatient treatment but in-patient treatment (IP) is frequently indicated due to acute medical instability or for those who have not improved with outpatient treatment. This IP can target either a partial weight restauration or a total weight normalization (return to the previous BMI growth trajectory). There are no evidence in the literature on which is the better therapeutic option in EOAN. But as long length of stay induce social isolation, with elevated costs, we wonder if a stepped-care model of daypatient treatment (DP) after short IP stabilisation may be a treatment option as effective as full-time IP to target weight normalization. We designed a two-arm randomised controlled trial testing the non-inferiority of a stepped-care model of DP after short IP stabilisation versus full-time IP.
Methods: 88 children aged 8 to 13 years suffering from EOAN with initial severe undernutrition will be randomly allocated to either IP treatment as usual or a stepped care DP model both targeting weight normalization. Assessments will be conducted at inclusion, somatic stabilization, weight normalization, 6 months and 12 months post randomisation. The primary outcome will be BMI at 12 months post-randomisation. Secondaries outcomes will included clinical (tanner stage), biological (prealbumin, leptin, total ghrelin and IGF1) and radiological (bone mineralization and maturation) outcomes, eating symptomatology and psychiatric assessments, motivation to change, treatment acceptability and quality of life assessments, cost-utility and cost-effectiveness analyses.
Discussion: COTIDEA will provide rigorous evaluation of treatment alternative to full-time inpatient treatment to allow a reduction of social iatrogenic link to hospital length of stay and associated costs.
Trial registration: Trial is registered on ClinicalTrials.gov (NCT04479683).
Disease Recognition and Early Reporting of Suspected African Swine Fever In Baybay City, Leyte, Philippines: A KAP Study
Authors: Wheless Sheena Mae S. , Portugaliza Harvie P.
Published: September 2023

This study assessed the knowledge, attitudes, and practices (KAP) toward ASF recognition and early reporting in selected stakeholders in Baybay City, Leyte. A KAP survey was conducted among farmers, meat sellers, butchers, and LGU personnel (N= 270). Logistic regression analysis was performed to identify factors associated with each KAP score. Most stakeholders demonstrated poor knowledge of ASF recognition, reflecting a poor understanding of ASF concepts. Good knowledge of ASF, college education, and young age were associated with good knowledge of case reporting. Most stakeholders demonstrated good attitudes toward early reporting, correlating to a high education level. Most stakeholders are unlikely to consume or sell potentially infected pigs; however, stakeholders’ type and sex influenced these attitudes. Good knowledge and not good attitudes translated into good practices of ASF reporting. This KAP study reveals the need to improve knowledge and practices of ASF disease recognition and early case reporting, especially among farmers.
Antioxidant, Electrochemical, Photocatalysis and Sensor Studies of rGO Incorporated MgO Nanocomposite
Authors: M Mylarappa , S Chandruvasan , N Shravana Kumara K , R Sandhya
Published: September 2023

The main objective of this study is to develop the reduced graphene oxide (rGO) with magnesium oxide (MgO) nanoparticles. The obtained nanocomposite was characterized by using XRD, SEM and EDAX techniques. The developed rGO/MgO nanocomposite was utilized for antioxidant property. The Antioxidant activity of rGO, MgO and rGO/MgO nanocomposite were estimated using DPPH assay shows a greater antioxidant activity 83 % and lower IC50 about 2609.23 mg/mL for rGO/MgO nanocomposite. The cyclic voltammetry (CV) analysis was performed using carbon paste electrode in 1M KOH electrolyte. From CV studies, electrochemical reversibility at scan rate 10 mV/s (ER= 2.0810−6), proton diffusion co-efficient (D= 1.765 × 10−4) and capacitance (𝐶𝑠𝑝 = 173𝐹𝑔−1) has been improved significantly. The photodegradation of malachite green was carried out for rGO, MgO and rGO/MgO nanocomposite shows a greater degradation about 93% and follows 1st order kinetics. Further, sensing property of the synthesized material by utilizing Ascorbic acid (BS-A), Resorcinol (BS-R) and Uric acid (BS-U) exhibit a good sensing in the oxidation region.
In-vivo Calibration of Corneal Biomechanical Properties by Virtual Fields Method
Authors: Jannesari Mohammad , Kasprzak Henryk
Published: September 2023

Understanding corneal biomechanics plays an essential role in investigating ophthalmological procedures, such as refractive surgeries, and in diagnosing diseases like keratoconus. One of the most significant issues in corneal biomechanics is the in-vivo characterization of the human cornea. In this current research, the virtual fields method, based on the principle of virtual work, is employed to calibrate corneal biomechanical properties. To achieve this, corneal full-field deformation was derived for five healthy patients from images captured by the Corvis ST tonometer, using image processing techniques. Subsequently, by applying the principle of virtual work to the obtained data, the material parameters can be derived by minimizing a cost function that balances the virtual internal and external works at different time instances. To assess the method's ability to calibrate different models, two material models (isotropic and anisotropic) were selected, and their parameters were calculated. The results demonstrate that the virtual fields method can accurately characterize in-vivo corneal biomechanical properties using tonometry data, without the need to worry about the uniqueness of the solution. Moreover, the time required to calculate these properties is approximately five minutes, making the virtual fields method a suitable choice for clinical applications compared to other methods.
Cellular Patterning Alone Using Bioprinting Regenerates Articular Cartilage through Native-Like Cartilagenesis
Authors: Grottkau Brian E. , Hui Zhixin , Pang Yonggang
Published: September 2023

Few studies have proved that bioprinting itself helps recapitulate native tissue functions mainly because the bioprinted macro shape can rarely, if ever, influence cell function. This can be more problematic in bioprinting cartilage, generally considered more challenging to engineer. Here we show a new method to micro-pattern chondrocytes within bioprinted sub-millimeter articular micro-cartilage tissues (PA-MCTs) under the sole influence of bioprinted cellular patterns. A pattern scoring system is developed after over 600 bioprinted cellular patterns are analyzed. The top-scored pattern mimics that of the isogenous group in native articular cartilage. Under the sole influence of this pattern during PA-MCTs bio-assembling into macro-cartilage and repairing cartilage defects, chondrogenic cell phenotype is preserved, and cartilagenesis is initiated and maintained. Neocartilage tissues from individual and assembled PA-MCTs are comparable to native articular cartilage and superior to cartilage bioprinted with homogeneously distributed cells in morphology, biochemical components, cartilage-specific protein and gene expression, mechanical properties, integration with host tissues, zonation forming and stem cell chondrogenesis. PA-MCTs can also be used as osteoarthritic and healthy cartilage models for therapeutic drug screening and cartilage development studies. This cellular patterning technique could pave a new way for bioprinting to recapitulate native tissue functions via tissue genesis.
Unravelling the Amorphous Structure, Nanoscale Effects, and Crystallization Mechanism of GeTe Phase Change Memory Material
Authors: Wintersteller Simon , Yarema Olesya , Kumaar Dhananjeya , Schenk Florian M. , Safonova Olga , Abdala Paula M. , Wood Vanessa , Yarema Maksym
Published: September 2023

The reversible phase transitions in phase-change memory devices can switch on the order of nanoseconds, suggesting a close structural resemblance between the amorphous and crystalline phases. In contrast, the amorphous structure is generally assumed to consist of a highly random ordering of atoms, quite distant to its crystalline counterpart. This work uses in-situ high-temperature x-ray absorption spectroscopy (XAS) and theoretical calculations to quantify the amorphous structure of bulk and nanoscale GeTe. Based on XAS experiments, we develop a theoretical model of the amorphous GeTe structure, consisting of a disordered fcc-type Te sublattice and randomly arranged chains of Ge atoms in a tetrahedral coordination. Strikingly, our intuitive and scalable model provides an accurate description of the structural dynamics in phase-change memory materials, observed experimentally. Specifically, we present a detailed crystallization mechanism through the formation of an intermediate, partially stable, ‘ideal glass’ state and demonstrate differences between bulk and nanoscale GeTe leading to size-dependent crystallization temperature.
Indications for laparoscopic surgery at Al-Ahli Specialized Hospital in Damascus
Authors: Fadlallh Samer Awad , Fateh Ghaith Samer , Fawares Maamoun AL- , Al-Sakka Kanaan Salah Al-Din
Published: September 2023

Background: In addition to a shorter hospital stay and better cosmetic results, laparoscopic surgery offers fewer postoperative complications compared to traditional gynecological operations and, with the acquisition of experience, it has become an alternative surgical approach to the diagnosis and treatment of gynecological diseases.
Aim: The study aims to know the indications for laparoscopic surgery at Al-Ahli Specialized Hospital in Damascus.
Methods and material: The study included 130 patients who were admitted to Al-Ahly Specialized Hospital, where a cross-sectional study was conducted according to certain criteria, in the months of 4, 5, and 6 of the year 2023, where information was collected according to the research form that includes information (age, surgical history, medical history, diagnostic and therapeutic indication, diagnosis Final), and the data were analyzed using Spss-28 software.
Results: During the period in which we conducted our study, 130 laparoscopy procedures were performed for gynecological operations. The average age of the patients was (33.31 ± 9.391 years), and the patients mainly had secondary infertility (33.5%), primary infertility (25.8%), and pain. Abdominal and dorsal (11.6%), 4.6% of patients had spontaneous miscarriages, 21.5% of patients had mainly previous cesarean sections, 21.5% had mainly chronic salpingitis, 19.6% had tubo-pelvic adhesions, and 15 3% ovulatory dysfunction, and 5.8% tubo-ovarian adhesions. The adhesions were removed laparoscopically in 53.4%, methylene blue injections were performed in 10.7%, right and left ovarian cysts were removed (7.3% for each), and ovarian excavation (6.6%). and fibroid resection (1.7%).
conclusion: Laparoscopic surgery provides patients with a new option for intervention that provides a final diagnosis, and also provides fewer complications, a shorter stay in the hospital, and also contributes significantly to the treatment of gynecological diseases such as infertility of both types, fibroids, ectopic pregnancy and endometrial migration, through which the uterus can be partially removed. Or complete.
Shallow water memory: Stokes and Darwin drifts
Authors: Sheikh-Jabbari Mohammad Mehdi , Taghiloo Vahid , Vahidinia Mohammad Hassan
Published: September 2023

It has been shown in [SciPost Phys. 14, 102 (2023)] that shallow water in the Euler description admits a dual gauge theory formulation. We show in the Lagrange description this gauge symmetry is a manifestation of the 2 dimensional area-preserving diffeomorphisms. We find surface charges associated with the gauge symmetry and their algebra, and study their physics in the shallow water system. In particular, we provide a reinterpretation of the Kelvin circulation theorem in terms of conserved charges. In the linear shallow water case, the charges form a u(1) current algebra with level proportional to the Coriolis parameter over the height of the fluid. We also study memory effect for the gauge theory description of the linearized shallow water and show Euler, Stokes and Darwin drifts can be understood as a memory effect and/or change of the surface charges in the gauge theory description.
Quasi-equilibrium polariton condensates in the non-linear regime and beyond
Authors: Goodman Ned , Mulkerin Brendan C. , Levinsen Jesper , Parish Meera M.
Published: September 2023

We investigate the many-body behavior of polaritons formed from electron-hole pairs strongly coupled to photons in a two-dimensional semiconductor microcavity. We use a microscopic mean-field BCS theory that describes polariton condensation in quasi-equilibrium across the full range of excitation densities. In the limit of vanishing density, we show that our theory recovers the exact single-particle properties of polaritons, while at low densities it captures non-linear polariton-polariton interactions within the Born approximation. For the case of highly screened contact interactions between charge carriers, we obtain analytic expressions for the equation of state of the many-body system. This allows us to show that there is a photon resonance at a chemical potential higher than the photon cavity energy, where the electron-hole pair correlations in the polariton condensate become universal and independent of the details of the carrier interactions. Comparing the effect of different ranged interactions between charge carriers, we find that the Rytova-Keldysh potential (relevant to transition metal dichalcogenides) offers the best prospect of reaching the BCS regime, where pairs strongly overlap and the minimum pairing gap occurs at finite momentum. Finally, going beyond thermal equilibrium, we argue that there are generically two polariton branches in the driven-dissipative system and we discuss the possibility of a density-driven exceptional point within our model.
Recomposiciones rurales contemporáneas: configuración territorial del distrito de riego del Alto Chicamocha, Boyacá, Colombia, 1989-2019
Authors: Castro-Ricaurte Danilo , Cardenas Maria F.
Published: September 2023

La multifuncionalidad como característica de la ruralidad refleja los cambios mediados por estrategias de desarrollo rural. Este trabajo analiza la ruralidad del distrito de riego del Alto Chicamocha a partir de información socioeconómica, situación predial, cambios en las coberturas de la tierra, planes de ordenamiento territorial junto a un análisis del paisaje. Se identifican las actividades productivas y usos de la tierra, permitiendo el establecimiento de ámbitos de ruralidad reflejo de la relación urbano-rural contemporánea, donde el rol de las comunidades locales es central en la reconfiguración de una ruralidad enmarcada por el avance del turismo y la urbanización.
Poder que engendra poder. Álvaro García Romero y el poder político en Sucre, 1966-2020
Authors: Duque Daza Javier
Published: September 2023

En el artículo se reconstruye la historia de la familia García Romero en el departamento de Sucre, en la región del Caribe de Colombia, como un caso significativo de la predeterminación social y económica del poder político. Se parte del neoinstitucionalismo contextualizado o sociológico para verificar cómo en ciertos contextos sociales quienes son poderosos económicamente y ejercen influencia social tienen ventajas para acceder a las posiciones de poder político, en comparación con quienes carecen de ellas. En estos casos, las estructuras de poder se caracterizan por la presencia continuada de algunas pocas familias que concentran las principales posiciones políticas durante largos periodos. En los resultados se muestran las estructuras y las relaciones de poder político que favorecen al clan político estudiado.
Representaciones sociales sobre aves y mamíferos silvestres: un acercamiento a las comunidades rurales del Quindío, Colombia
Authors: Parra Colorado Jean Wilman , Molina Rico Ligia Janneth , Marín Norberto
Published: September 2023

El presente estudio tuvo por objetivo determinar las Representaciones Sociales (en adelante RS) que las comunidades rurales poseen sobre las aves y mamíferos silvestres en las veredas El Vergel del municipio de Filandia y San Rafael del municipio de Calarcá-Quindío, a través de herramientas etnográficas como la encuesta y la entrevista semiestructurada. Se utilizó el enfoque de investigación cualitativa apoyado con análisis cuantitativos que, mediante el análisis de categorías a través de la oralidad como herramienta de comunicación y reflexión de las prácticas sociales y culturales, busca la comprensión de las comunidades rurales sobre su relación con el ambiente. La información sobre el modo en que se conciben las aves y los mamíferos silvestres fue analizada a través de las dimensiones constitutivas de las RS (cognitivas, emocionales y simbólicas). Se encontró que las representaciones que el ser humano construye en relación con los componentes ambientales en los que se encuentra inmerso es compleja en términos de percepción, valoración y construcción de atributos objetivos y subjetivos que influyen en sus actividades cotidianas y que, a su vez, configuran su modo de estar en el mundo.
Comportamiento de ahorro de agua y energía en hogares de estudiantes universitarios de Medellín
Authors: Salas Zapata Walter , Mejía Durango Diana , Posada Castaño Anny , Duarte Duarte Jakeline
Published: September 2023

Introducción: Los estudios sobre comportamiento de ahorro de agua y energía comúnmente analizan el papel de las motivaciones y barreras en la adopción de este tipo de comportamiento. En esta investigación se incluyó la categoría, realimentación, con la intención de revelar su existencia y origen en la cotidianidad de las personas. Objetivo: Describir el comportamiento de ahorro de hogares de estudiantes universitarios y el papel que juegan las motivaciones, la realimentación y las barreras. Método: Investigación cualitativa. Resultados: Se encontró un predominio de las motivaciones económicas sobre las ambientales, un arreglo institucional en los hogares que origina la realimentación y hace que por esta se adopten comportamientos de ahorro, y tres tipos de barreras que enfrentan las personas frente al ahorro. Conclusión: Al igual que las motivaciones y las barreras, la realimentación también juega un papel importante en la adopción del comportamiento de ahorro.
Feminización migratoria pendular y flotante en la frontera araucana: una revisión documental
Authors: Bastos Castañeda Laura , Ortiz Piedrahita Vanessa
Published: September 2023

Objetivo: en el presente artículo de revisión se describe y analiza la literatura académica e institucional sobre el fenómeno migratorio en la frontera colombo-venezolana, con el objetivo de contribuir con la caracterización y estudio de las condiciones de vida de las inmigrantes venezolanas en Colombia, particularmente en Arauca; hecho indispensable para la planeación de políticas públicas nacionales y locales y la comprensión de flujos migratorios poco explorados como los pendulares y flotantes. Metodología: se revisaron estudios en el campo de las ciencias sociales con enfoque de género y desde la perspectiva de los estudios migratorios sur-sur. Conclusiones: de acuerdo con los estudios analizados, es importante la regularización de migrantes en el país para controlar la informalidad y los escenarios de violación de derechos humanos y brindar una real integración social.