bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comparative Study of The Proximate Composition of Selected Rice Varieties in Tangail, Bangladesh
Authors: Zubair MA , Rahman MS , Islam MS , Abedin MZ , Sikder MA
Published: February 2016

An investigation was conducted to assess the approximate nutrient composition of Miniket rice collected from different regions and market places of Tangail district in Bangladesh to understand actual fact. Moreover, mostly available variety BRRI-28 milled rice was also analysed to compare with the Miniket milled rice.Moisture, protein, fat, crude fibre, and ash content were higher in Miniket brown rice as compared to the parboiled milled rice except available carbohydrate. Among Miniket parboiled milled rice, Miniket TM-1 (Tangail Market-1) rice and Miniket TM-2 (Tangail Market-2) rice, the content of protein (7.04%), fat (0.37%), crude fibre (0.26%) and ash (0.58%) were comparatively higher in parboiled milled rice than that of two market samples. In a comparison among other cheaper coarse varieties like BRRI-28 and Miniket TM-1 rice and Miniket TM-2 rice, protein, fat, crude fibre and ash content were found lower in Miniket rice of TM-1 and TM-2 than BRRI-28. Beside chemical composition, some physical properties were studied including length, width, L/W ratio, shape and weight.J. Environ. Sci. & Natural Resources, 8(2): 97-102 2015
Physicochemical Properties and Metallic Constituent Load in the Water Samples of the Buriganga of Bangladesh
Authors: Mohiuddin KM , Alam MM , Ahmed I , Zakir HM , Chowdhury AK
Published: February 2016

The study was conducted to assess the level of Cu, Zn, Pb, Cr, Fe, Mn, Cd and Ni contamination in the water samples of the Buriganga river. Total 14 water samples were collected from different areas of upstream of the Buriganga river to determine the physicochemical properties, concentration of different metallic constituents and assess the heavy metal pollution load. Atomic Absorption Spectrometer was used for analyzing the heavy metals of the samples. The mean concentration of Ca, Mg, Na, K in water samples were 0.779, 0.889, 140.39, 26.9 ?g mL-1, respectively. The mean concentration of Cr, Pb, Fe, Cu, Zn and Mn in the water samples were 0.17, 0.05, 0.67, 0.22, 0.55 and 0.17 ?g mL-1, respectively. The amount of Cd in all samples and Pb in 10 samples was below detectable limit of the instrument (0.01 ?g mL-1). Water pH ranged from 4.09 to 7.41 and EC was 346 to 7720 µS cm-1. Magnitude of heavy metal pollution in the Buriganga river system implies that the condition is very alarming and may severely affect the aquatic ecology of the river. To minimize the severe impact on city dwellers and aquatic ecology of the Buriganga river, sustainable steps and continuous monitoring on pollution prevention and cleanup operation is suggested.J. Environ. Sci. & Natural Resources, 8(2): 141-146 2015
Adaptive Piezoelectric Absorber for Active Vibration Control
Authors: Herold Sven , Mayer Dirk
Published: February 2016

Passive vibration control solutions are often limited to working reliably at one design point. Especially applied to lightweight structures, which tend to have unwanted vibration, active vibration control approaches can outperform passive solutions. To generate dynamic forces in a narrow frequency band, passive single-degree-of-freedom oscillators are frequently used as vibration absorbers and neutralizers. In order to respond to changes in system properties and/or the frequency of excitation forces, in this work, adaptive vibration compensation by a tunable piezoelectric vibration absorber is investigated. A special design containing piezoelectric stack actuators is used to cover a large tuning range for the natural frequency of the adaptive vibration absorber, while also the utilization as an active dynamic inertial mass actuator for active control concepts is possible, which can help to implement a broadband vibration control system. An analytical model is set up to derive general design rules for the system. An absorber prototype is set up and validated experimentally for both use cases of an adaptive vibration absorber and inertial mass actuator. Finally, the adaptive vibration control system is installed and tested with a basic truss structure in the laboratory, using both the possibility to adjust the properties of the absorber and active control.
A Visualization Approach to Air Pollution Data Exploration—A Case Study of Air Quality Index (PM2.5) in Beijing, China
Authors: Li Huan , Fan Hong , Mao Feiyue
Published: February 2016

In recent years, frequent occurrences of significant air pollution events in China have routinely caused panic and are a major topic of discussion by the public and air pollution experts in government and academia. Therefore, this study proposed an efficient visualization method to represent directly, quickly, and clearly the spatio-temporal information contained in air pollution data. Data quality check and cleansing during a preliminary visual analysis is presented in tabular form, heat matrix, or line chart, upon which hypotheses can be deduced. Further visualizations were designed to verify the hypotheses and obtain useful findings. This method was tested and validated in a year-long case study of the air quality index (AQI of PM2.5) in Beijing, China. We found that PM2.5, PM10, and NO2 may be emitted by the same sources, and strong winds may accelerate the spread of pollutants. The average concentration of PM2.5 in Beijing was greater than the AQI value of 50 over the six-year study period. Furthermore, arable lands exhibited considerably higher concentrations of air pollutants than vegetation-covered areas. The findings of this study showed that our visualization method is intuitive and reliable through data quality checking and information sharing with multi-perspective air pollution graphs. This method allows the data to be easily understood by the public and inspire or aid further studies in other fields.
Regeneration and Repair in Endodontics—A Special Issue of the Regenerative Endodontics—A New Era in Clinical Endodontics
Authors: Saoud Tarek , Ricucci Domenico , Lin Louis , Gaengler Peter
Published: February 2016

Caries is the most common cause of pulp-periapical disease. When the pulp tissue involved in caries becomes irreversibly inflamed and progresses to necrosis, the treatment option is root canal therapy because the infected or non-infected necrotic pulp tissue in the root canal system is not accessible to the host's innate and adaptive immune defense mechanisms and antimicrobial agents. Therefore, the infected or non-infected necrotic pulp tissue must be removed from the canal space by pulpectomy. As our knowledge in pulp biology advances, the concept of treatment of pulpal and periapical disease also changes. Endodontists have been looking for biologically based treatment procedures, which could promote regeneration or repair of the dentin-pulp complex destroyed by infection or trauma for several decades. After a long, extensive search in in vitro laboratory and in vivo preclinical animal experiments, the dental stem cells capable of regenerating the dentin-pulp complex were discovered. Consequently, the biological concept of ‘regenerative endodontics’ emerged and has highlighted the paradigm shift in the treatment of immature permanent teeth with necrotic pulps in clinical endodontics. Regenerative endodontics is defined as biologically based procedures designed to physiologically replace damaged tooth structures, including dentin and root structures, as well as the pulp-dentin complex. According to the American Association of Endodontists’ Clinical Considerations for a Regenerative Procedure, the primary goal of the regenerative procedure is the elimination of clinical symptoms and the resolution of apical periodontitis. Thickening of canal walls and continued root maturation is the secondary goal. Therefore, the primary goal of regenerative endodontics and traditional non-surgical root canal therapy is the same. The difference between non-surgical root canal therapy and regenerative endodontic therapy is that the disinfected root canals in the former therapy are filled with biocompatible foreign materials and the root canals in the latter therapy are filled with the host's own vital tissue. The purpose of this article is to review the potential of using regenerative endodontic therapy for human immature and mature permanent teeth with necrotic pulps and/or apical periodontitis, teeth with persistent apical periodontitis after root canal therapy, traumatized teeth with external inflammatory root resorption, and avulsed teeth in terms of elimination of clinical symptoms and resolution of apical periodontitis.
Self-Replicating Spots in the Brusselator Model and Extreme Events in the One-Dimensional Case with Delay
Authors: Tlidi Mustapha , Gandica Yerali , Sonnino Giorgio , Averlant Etienne , Panajotov Krassimir
Published: February 2016

We consider the paradigmatic Brusselator model for the study of dissipative structures in far from equilibrium systems. In two dimensions, we show the occurrence of a self-replication phenomenon leading to the fragmentation of a single localized spot into four daughter spots. This instability affects the new spots and leads to splitting behavior until the system reaches a hexagonal stationary pattern. This phenomenon occurs in the absence of delay feedback. In addition, we incorporate a time-delayed feedback loop in the Brusselator model. In one dimension, we show that the delay feedback induces extreme events in a chemical reaction diffusion system. We characterize their formation by computing the probability distribution of the pulse height. The long-tailed statistical distribution, which is often considered as a signature of the presence of rogue waves, appears for sufficiently strong feedback intensity. The generality of our analysis suggests that the feedback-induced instability leading to the spontaneous formation of rogue waves in a controllable way is a universal phenomenon.
Numerical Investigation of Influence of In-Situ Stress Ratio, Injection Rate and Fluid Viscosity on Hydraulic Fracture Propagation Using a Distinct Element Approach
Authors: Zhang Bo , Li Xiao , Zhang Zhaobin , Wu Yanfang , Wu Yusong , Wang Yu
Published: February 2016

Numerical simulation is very useful for understanding the hydraulic fracturing mechanism. In this paper, we simulate the hydraulic fracturing using the distinct element approach, to investigate the effect of some critical parameters on hydraulic fracturing characteristics. The breakdown pressure obtained by the distinct element approach is consistent with the analytical solution. This indicates that the distinct element approach is feasible on modeling the hydraulic fracturing. We independently examine the influence of in-situ stress ratio, injection rate and fluid viscosity on hydraulic fracturing. We further emphasize the relationship between these three factors and their contributions to the hydraulic fracturing. With the increase of stress ratio, the fracture aperture increases almost linearly; with the increase of injection rate and fluid viscosity, the fracture aperture and breakdown pressure increase obviously. A low value of product of injection rate and fluid viscosity (i.e., Qμ) will lead to narrow fracture aperture, low breakdown pressure, and complex or dispersional hydraulic fractures. A high value of Qμ would lead wide fracture aperture, high breakdown pressure, and simple hydraulic fractures (e.g., straight or wing shape). With low viscosity fluid, the hydraulic fracture geometry is not sensitive to stress ratio, and thus becomes a complex fracture network.
Anthropogenic Decline of Ecosystem Services Threatens the Integrity of the Unique Hyrcanian (Caspian) Forests in Northern Iran
Authors: Zarandian Ardavan , Baral Himlal , Yavari Ahmad , Jafari Hamid , Stork Nigel , Ling Matthew , Amirnejad Hamid
Published: February 2016

The unique Hyrcanian (Caspian) forests of northern Iran provide vital ecosystem services for local and global communities. We assess the status and trends of key ecosystem services in this region where native forest conversion has accelerated to make way for housing and farm development. This is a mountainous forested area that is valuable for both conservation and multiple human uses including recreation and farming. It contains globally significant natural habitats for in situ conservation of biological diversity. A rapid, qualitative, and participatory approach was used including interviews with local households and experts in combination with assessment of land use/cover remote sensing data to identify and map priority ecosystem services in the Geographic Information System (GIS). Based on the interests of the beneficiaries, eight priority services (food production, water supply, raw materials, soil conservation, water regulation, climate regulation, biodiversity, and recreation) were identified and mapped. The results indicate the current typical spatial distribution of the provided services based on structural characteristics of the study landscape and their changing trends through a comparison of past, present and future land use, and land cover. Although food production and recreation have greatly increased in recent decades, the other services, in particular timber production, biodiversity, and water purification and supply are being gradually lost. The results of this study and of others elsewhere should raise awareness of ecosystem service status and trends and the value of examining these since they provide much of the information to inform natural resources policy and decision making. The declines in supply of key ecosystem services both within and outside the protected area are creating conflicts within communities as well as impacting on the integrity of the area and careful planning and conservation is required to provide win-win opportunities.
Complex Challenges of Maintaining Whitebark Pine in Greater Yellowstone under Climate Change: A Call for Innovative Research, Management, and Policy Approaches
Authors: Hansen Andrew , Ireland Kathryn , Legg Kristin , Keane Robert , Barge Edward , Jenkins Martha , Pillet Michiel
Published: February 2016

Climate suitability is projected to decline for many subalpine species, raising questions about managing species under a deteriorating climate. Whitebark pine (WBP) (Pinus albicaulis) in the Greater Yellowstone Ecosystem (GYE) crystalizes the challenges that natural resource managers of many high mountain ecosystems will likely face in the coming decades. We review the system of interactions among climate, competitors, fire, bark beetles, white pine blister rust (Cronartium ribicola), and seed dispersers that make WBP especially vulnerable to climate change. A well-formulated interagency management strategy has been developed for WBP, but it has only been implemented across <1% of the species GYE range. The challenges of complex climate effects and land allocation constraints on WBP management raises questions regarding the efficacy of restoration efforts for WBP in GYE. We evaluate six ecological mechanisms by which WBP may remain viable under climate change: climate microrefugia, climate tolerances, release from competition, favorable fire regimes, seed production prior to beetle-induced mortality, and blister-rust resistant trees. These mechanisms suggest that WBP viability may be higher than previously expected under climate change. Additional research is warranted on these mechanisms, which may provide a basis for increased management effectiveness. This review is used as a basis for deriving recommendations for other subalpine species threatened by climate change.
Genome-Wide Identification and Characterization of Long Non-Coding RNAs from Mulberry (Morus notabilis) RNA-seq Data
Authors: Song Xiaobo , Sun Liang , Luo Haitao , Ma Qingguo , Zhao Yi , Pei Dong
Published: February 2016

Numerous sources of evidence suggest that most of the eukaryotic genome is transcribed into protein-coding mRNAs and also into a large number of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs), a group consisting of ncRNAs longer than 200 nucleotides, have been found to play critical roles in transcriptional, post-transcriptional, and epigenetic gene regulation across all kingdoms of life. However, lncRNAs and their regulatory roles remain poorly characterized in plants, especially in woody plants. In this paper, we used a computational approach to identify novel lncRNAs from a published RNA-seq data set and analyzed their sequences and expression patterns. In total, 1133 novel lncRNAs were identified in mulberry, and 106 of these lncRNAs displayed a predominant tissue-specific expression in the five major tissues investigated. Additionally, functional predictions revealed that tissue-specific lncRNAs adjacent to protein-coding genes might play important regulatory roles in the development of floral organ and root in mulberry. The pipeline used in this study would be useful for the identification of lncRNAs obtained from other deep sequencing data. Furthermore, the predicted lncRNAs would be beneficial towards an understanding of the variations in gene expression in plants.
Reduction of Endogenous Melatonin Accelerates Cognitive Decline in Mice in a Simulated Occupational Formaldehyde Exposure Environment
Authors: Mei Yufei , Duan Chunli , Li Xiaoxiao , Zhao Yun , Cao Fenghua , Shang Shuai , Ding Shumao , Yue Xiangpei , Gao Ge , Yang Hui , Shen Luxi , Feng Xueyan , Jia Jianping , Tong Zhiqian , Yang Xu
Published: February 2016

Individuals afflicted with occupational formaldehyde (FA) exposure often suffer from abnormal behaviors such as aggression, depression, anxiety, sleep disorders, and in particular, cognitive impairments. Coincidentally, clinical patients with melatonin (MT) deficiency also complain of cognitive problems associated with the above mental disorders. Whether and how FA affects endogenous MT metabolism and induces cognitive decline need to be elucidated. To mimic occupational FA exposure environment, 16 healthy adult male mice were exposed to gaseous FA (3 mg/m3) for 7 consecutive days. Results showed that FA exposure impaired spatial memory associated with hippocampal neuronal death. Biochemical analysis revealed that FA exposure elicited an intensive oxidative stress by reducing systemic glutathione levels, in particular, decreasing brain MT concentrations. Inversely, intraperitoneal injection of MT markedly attenuated FA-induced hippocampal neuronal death, restored brain MT levels, and reversed memory decline. At tissue levels, injection of FA into the hippocampus distinctly reduced brain MT concentrations. Furthermore, at cellular and molecular levels, we found that FA directly inactivated MT in vitro and in vivo. These findings suggest that MT supplementation contributes to the rescue of cognitive decline, and may alleviate mental disorders in the occupational FA-exposed human populations.
Evaluation of Lead Release in a Simulated Lead-Free Premise Plumbing System Using a Sequential Sampling Approach
Authors: Ng Ding-Quan , Lin Yi-Pin
Published: February 2016

In this pilot study, a modified sampling protocol was evaluated for the detection of lead contamination and locating the source of lead release in a simulated premise plumbing system with one-, three- and seven-day stagnation for a total period of 475 days. Copper pipes, stainless steel taps and brass fittings were used to assemble the “lead-free” system. Sequential sampling using 100 mL was used to detect lead contamination while that using 50 mL was used to locate the lead source. Elevated lead levels, far exceeding the World Health Organization (WHO) guideline value of 10 µg·L−1, persisted for as long as five months in the system. “Lead-free” brass fittings were identified as the source of lead contamination. Physical disturbances, such as renovation works, could cause short-term spikes in lead release. Orthophosphate was able to suppress total lead levels below 10 µg·L−1, but caused “blue water” problems. When orthophosphate addition was ceased, total lead levels began to spike within one week, implying that a continuous supply of orthophosphate was required to control total lead levels. Occasional total lead spikes were observed in one-day stagnation samples throughout the course of the experiments.
The Effect of Exposure to Persistent Organic Pollutants on Metabolic Health among KOREAN Children during a 1-Year Follow-Up
Authors: Lee Hye , Park Su , Hong Young , Ha Eun , Park Hyesook
Published: February 2016

Previous evidence suggests the potential for adverse effects of persistent organic pollutants (POPs) on metabolic health even at low-dose exposure levels common among the general population, but there is less evidence of these associations among children. Therefore, as part of a prospective cohort study, 214 children were measured for POPs exposure. After the 1-year follow-up, we assessed the effect of circulating POPs exposure among 158 children aged 7–9 years (at baseline) on the change of metabolic components of metabolic syndrome using multiple regression analysis. In addition, we calculated the continuous metabolic syndrome (cMetS) score and assessed the variation among individuals by POPs exposure. The concentrations of marker polychlorinated biphenyls (PCBs) were significantly associated with increased change in diastolic blood pressure (BP) and triglyceride levels during a 1-year follow-up, after controlling for sex, age, household income, and change in body mass index. Total PCBs also showed a marginal association with increasing cMetS score from the baseline. Of the metabolic components, change in diastolic BP over time showed a notable association with specific PCBs, but no association with organochlorine pesticides. Here, we found that low-dose exposures to PCBs among children in the general population could negatively influence metabolic health, particularly diastolic BP. Increased disease sensitivity during childhood can continue to adulthood, thus, these results support the need for continuous assessment of the health impact of POPs.
Spatio-Temporal Patterns of Urban-Rural Development and Transformation in East of the “Hu Huanyong Line”, China
Authors: Hu Zhichao , Wang Yanglin , Liu Yansui , Long Hualou , Peng Jian
Published: February 2016

Urban-rural development and transformation is profoundly changing the socioeconomic system as well as the natural environment. The study uses the AHP (Analytic Hierarchy Process) method to construct a top-down index of human activity based around five dimensions (population, land, industry, society, and environment) to evaluate the spatial characteristics in the region east of the Hu Huanyong line, China, in 1994 and 2010. Then, we investigate the spatial-temporal pattern using the methods of hotspot analysis, local Moran’s I index and Pearson correlation coefficient. The calculation showed that: (1) northeast China was experiencing an economic recession during study period, and the implementation of revitalization plan have not controlled the recession trend yet; (2) Pearson correlation analysis showed that the improvement of population quality promote the development of industry and society systems significantly during study period; and (3) negative correlation between Population Development Index (PDI) change and Population Transformation Index (PTI) change (along with the Society Transformation Index (STI) change and Industry Transformation Index (ITI) change) reflected that east of the Hu Huanyong line, China was in a “demographic dividend” period. Then, with the help of SOFM neural network algorithm, we divided the study area into six types of region, and found that municipalities, provincial capitals, Yangtze River Delta region and cities on the North China Plain owned the greatest development, while cities in southwest and northeast China showed relatively poor development during study period.
Potentially Treatable Disorder Diagnosed Post Mortem by Exome Analysis in a Boy with Respiratory Distress
Authors: Imperatore Valentina , Mencarelli Maria , Fallerini Chiara , Bianciardi Laura , Ariani Francesca , Furini Simone , Renieri Alessandra , Mari Francesca , Frullanti Elisa
Published: February 2016

We highlight the importance of exome sequencing in solving a clinical case of a child who died at 14 months after a series of respiratory crises. He was the half-brother of a girl diagnosed at 7 years with the early-onset seizure variant of Rett syndrome due to CDKL5 mutation. We performed a test for CDKL5 in the boy, which came back negative. Driven by the mother’s compelling need for a diagnosis, we moved forward performing whole exome sequencing analysis. Surprisingly, two missense mutations in compound heterozygosity were identified in the RAPSN gene encoding a receptor-associated protein with a key role in clustering and anchoring nicotinic acetylcholine receptors at synaptic sites. This gene is responsible for a congenital form of myasthenic syndrome, a disease potentially treatable with cholinesterase inhibitors. Therefore, an earlier diagnosis in this boy would have led to a better clinical management and prognosis. Our study supports the key role of exome sequencing in achieving a definite diagnosis in severe perinatal diseases, an essential step especially when a specific therapy is available.
Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis
Authors: Lau Susanna , Lee Kim-Chung , Lo George , Ding Vanessa , Chow Wang-Ngai , Ke Tony , Curreem Shirly , To Kelvin , Ho Deborah , Sridhar Siddharth , Wong Sally , Chan Jasper , Hung Ivan , Sze Kong-Hung , Lam Ching-Wan , Yuen Kwok-Yung , Woo Patrick
Published: February 2016

To identify potential biomarkers for improving diagnosis of melioidosis, we compared plasma metabolome profiles of melioidosis patients compared to patients with other bacteremia and controls without active infection, using ultra-high-performance liquid chromatography-electrospray ionization-quadruple time-of-flight mass spectrometry. Principal component analysis (PCA) showed that the metabolomic profiles of melioidosis patients are distinguishable from bacteremia patients and controls. Using multivariate and univariate analysis, 12 significant metabolites from four lipid classes, acylcarnitine (n = 6), lysophosphatidylethanolamine (LysoPE) (n = 3), sphingomyelins (SM) (n = 2) and phosphatidylcholine (PC) (n = 1), with significantly higher levels in melioidosis patients than bacteremia patients and controls, were identified. Ten of the 12 metabolites showed area-under-receiver operating characteristic curve (AUC) >0.80 when compared both between melioidosis and bacteremia patients, and between melioidosis patients and controls. SM(d18:2/16:0) possessed the largest AUC when compared, both between melioidosis and bacteremia patients (AUC 0.998, sensitivity 100% and specificity 91.7%), and between melioidosis patients and controls (AUC 1.000, sensitivity 96.7% and specificity 100%). Our results indicate that metabolome profiling might serve as a promising approach for diagnosis of melioidosis using patient plasma, with SM(d18:2/16:0) representing a potential biomarker. Since the 12 metabolites were related to various pathways for energy and lipid metabolism, further studies may reveal their possible role in the pathogenesis and host response in melioidosis.
Bioinformatics Workflow for Clinical Whole Genome Sequencing at Partners HealthCare Personalized Medicine
Authors: Tsai Ellen , Shakbatyan Rimma , Evans Jason , Rossetti Peter , Graham Chet , Sharma Himanshu , Lin Chiao-Feng , Lebo Matthew
Published: February 2016

Effective implementation of precision medicine will be enhanced by a thorough understanding of each patient’s genetic composition to better treat his or her presenting symptoms or mitigate the onset of disease. This ideally includes the sequence information of a complete genome for each individual. At Partners HealthCare Personalized Medicine, we have developed a clinical process for whole genome sequencing (WGS) with application in both healthy individuals and those with disease. In this manuscript, we will describe our bioinformatics strategy to efficiently process and deliver genomic data to geneticists for clinical interpretation. We describe the handling of data from FASTQ to the final variant list for clinical review for the final report. We will also discuss our methodology for validating this workflow and the cost implications of running WGS.
Terpyridine and Quaterpyridine Complexes as Sensitizers for Photovoltaic Applications
Authors: Saccone Davide , Magistris Claudio , Barbero Nadia , Quagliotto Pierluigi , Barolo Claudia , Viscardi Guido
Published: February 2016

Terpyridine and quaterpyridine-based complexes allow wide light harvesting of the solar spectrum. Terpyridines, with respect to bipyridines, allow for achieving metal-complexes with lower band gaps in the metal-to-ligand transition (MLCT), thus providing a better absorption at lower energy wavelengths resulting in an enhancement of the solar light-harvesting ability. Despite the wider absorption of the first tricarboxylate terpyridyl ligand-based complex, Black Dye (BD), dye-sensitized solar cell (DSC) performances are lower if compared with N719 or other optimized bipyridine-based complexes. To further improve BD performances several modifications have been carried out in recent years affecting each component of the complexes: terpyridines have been replaced by quaterpyridines; other metals were used instead of ruthenium, and thiocyanates have been replaced by different pinchers in order to achieve cyclometalated or heteroleptic complexes. The review provides a summary on design strategies, main synthetic routes, optical and photovoltaic properties of terpyridine and quaterpyridine ligands applied to photovoltaic, and focuses on n-type DSCs.
Electrospun Nafion®/Polyphenylsulfone Composite Membranes for Regenerative Hydrogen Bromine Fuel Cells
Authors: Park Jun , Wycisk Ryszard , Pintauro Peter , Yarlagadda Venkata , Van Nguyen Trung
Published: February 2016

The regenerative H2/Br2-HBr fuel cell, utilizing an oxidant solution of Br2 in aqueous HBr, shows a number of benefits for grid-scale electricity storage. The membrane-electrode assembly, a key component of a fuel cell, contains a proton-conducting membrane, typically based on the perfluorosulfonic acid (PFSA) ionomer. Unfortunately, the high cost of PFSA membranes and their relatively high bromine crossover are serious drawbacks. Nanofiber composite membranes can overcome these limitations. In this work, composite membranes were prepared from electrospun dual-fiber mats containing Nafion® PFSA ionomer for facile proton transport and an uncharged polymer, polyphenylsulfone (PPSU), for mechanical reinforcement, and swelling control. After electrospinning, Nafion/PPSU mats were converted into composite membranes by softening the PPSU fibers, through exposure to chloroform vapor, thus filling the voids between ionomer nanofibers. It was demonstrated that the relative membrane selectivity, referenced to Nafion® 115, increased with increasing PPSU content, e.g., a selectivity of 11 at 25 vol% of Nafion fibers. H2-Br2 fuel cell power output with a 65 μm thick membrane containing 55 vol% Nafion fibers was somewhat better than that of a 150 μm Nafion® 115 reference, but its cost advantage due to a four-fold decrease in PFSA content and a lower bromine species crossover make it an attractive candidate for use in H2/Br2-HBr systems.
A Collaborative Evaluation of LC-MS/MS Based Methods for BMAA Analysis: Soluble Bound BMAA Found to Be an Important Fraction
Authors: Faassen Elisabeth , Antoniou Maria , Beekman-Lukassen Wendy , Blahova Lucie , Chernova Ekaterina , Christophoridis Christophoros , Combes Audrey , Edwards Christine , Fastner Jutta , Harmsen Joop , Hiskia Anastasia , Ilag Leopold , Kaloudis Triantafyllos , Lopicic Srdjan , Lürling Miquel , Mazur-Marzec Hanna , Meriluoto Jussi , Porojan Cristina , Viner-Mozzini Yehudit , Zguna Nadezda
Published: February 2016

Exposure to β-N-methylamino-l-alanine (BMAA) might be linked to the incidence of amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson’s disease. Analytical chemistry plays a crucial role in determining human BMAA exposure and the associated health risk, but the performance of various analytical methods currently employed is rarely compared. A CYANOCOST initiated workshop was organized aimed at training scientists in BMAA analysis, creating mutual understanding and paving the way towards interlaboratory comparison exercises. During this workshop, we tested different methods (extraction followed by derivatization and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) analysis, or directly followed by LC-MS/MS analysis) for trueness and intermediate precision. We adapted three workup methods for the underivatized analysis of animal, brain and cyanobacterial samples. Based on recovery of the internal standard D3BMAA, the underivatized methods were accurate (mean recovery 80%) and precise (mean relative standard deviation 10%), except for the cyanobacterium Leptolyngbya. However, total BMAA concentrations in the positive controls (cycad seeds) showed higher variation (relative standard deviation 21%–32%), implying that D3BMAA was not a good indicator for the release of BMAA from bound forms. Significant losses occurred during workup for the derivatized method, resulting in low recovery (<10%). Most BMAA was found in a trichloroacetic acid soluble, bound form and we recommend including this fraction during analysis.
Hybrid and Mixed Matrix Membranes for Separations from Fermentations
Authors: Davey Christopher , Leak David , Patterson Darrell
Published: February 2016

Fermentations provide an alternative to fossil fuels for accessing a number of biofuel and chemical products from a variety of renewable and waste substrates. The recovery of these dilute fermentation products from the broth, however, can be incredibly energy intensive as a distillation process is generally involved and creates a barrier to commercialization. Membrane processes can provide a low energy aid/alternative for recovering these dilute fermentation products and reduce production costs. For these types of separations many current polymeric and inorganic membranes suffer from poor selectivity and high cost respectively. This paper reviews work in the production of novel mixed-matrix membranes (MMMs) for fermentative separations and those applicable to these separations. These membranes combine a trade-off of low-cost and processability of polymer membranes with the high selectivity of inorganic membranes. Work within the fields of nanofiltration, reverse osmosis and pervaporation has been discussed. The review shows that MMMs are currently providing some of the most high-performing membranes for these separations, with three areas for improvement identified: Further characterization and optimization of inorganic phase(s), Greater understanding of the compatibility between the polymer and inorganic phase(s), Improved methods for homogeneously dispersing the inorganic phase.
Rhodium Porphyrin Bound to a Merrifield Resin as Heterogeneous Catalyst for the Cyclopropanation Reaction of Olefins
Authors: Ciammaichella Alina , Cardoni Valeria , Leoni Alessandro , Tagliatesta Pietro
Published: February 2016

Cyclopropanation reaction is an important tool for obtaining interesting compounds and can be catalyzed by metalloporphyrins with high syn/anti ratio. The catalyst cannot be recycled and is usually lost during chromatographic separation from the two isomeric products. In this paper a meso-tetraphenylporphyrin rhodium(III) chloride was bound to a Merrifield resin and used to catalyze the cyclopropanation reaction of nine olefins, giving good yields and selectivities of the final products and for the first time, a partial recycling of the catalyst. This new catalytic system will be tested in the future for the synthesis of natural products containing cyclopropyl ring.
Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood
Authors: Zhao Huan , Peng Qinghua , Han Zhuzhen , Yang Li , Wang Zhengtao
Published: February 2016

Three new sesquiterpenoids (1–3) and one new sesquiterpenoid derivative (4), along with three known sesquiterpenoids (5–7), were isolated from the 95% ethanolic extract of Chinese eaglewood [Aquilaria sinensis (Lour.) Gilg]. The structures of these compounds were elucidated through extensive analysis of spectroscopic data including IR, NMR, HRESIMS, and X-ray diffraction experiments. In addition, the above new compounds were detected for their bioactivities against LPS-induced NO production in RAW 264.7 cells. Among them, compound 2 exhibited obvious anti-inflammatory activity with an IC50 value of 8.1 μM.
Apple-Derived Pectin Modulates Gut Microbiota, Improves Gut Barrier Function, and Attenuates Metabolic Endotoxemia in Rats with Diet-Induced Obesity
Authors: Jiang Tingting , Gao Xuejin , Wu Chao , Tian Feng , Lei Qiucheng , Bi Jingcheng , Xie Bingxian , Wang Hong , Chen Shuai , Wang Xinying
Published: February 2016

This study was aimed at determining potential effects of apple-derived pectin on weight gain, gut microbiota, gut barrier and metabolic endotoxemia in rat models of diet-induced obesity. The rats received a standard diet (control; Chow group; n = 8) or a high-fat diet (HFD; n = 32) for eight weeks to induce obesity. The top 50th percentile of weight-gainers were selected as diet induced obese rats. Thereafter, the Chow group continued on chow, and the diet induced obese rats were randomly divided into two groups and received HFD (HF group; n = 8) or pectin-supplemented HFD (HF-P group; n = 8) for six weeks. Compared to the HF group, the HF-P group showed attenuated weight gain (207.38 ± 7.96 g vs. 283.63 ± 10.17 g, p < 0.01) and serum total cholesterol level (1.46 ± 0.13 mmol/L vs. 2.06 ± 0.26 mmol/L, p < 0.01). Compared to the Chow group, the HF group showed a decrease in Bacteroidetes phylum and an increase in Firmicutes phylum, as well as subordinate categories (p < 0.01). These changes were restored to the normal levels in the HF-P group. Furthermore, compared to the HF group, the HF-P group displayed improved intestinal alkaline phosphatase (0.57 ± 0.20 vs. 0.30 ± 0.19, p < 0.05) and claudin 1 (0.76 ± 0.14 vs. 0.55 ± 0.18, p < 0.05) expression, and decreased Toll-like receptor 4 expression in ileal tissue (0.76 ± 0.58 vs. 2.04 ± 0.89, p < 0.01). The HF-P group also showed decreased inflammation (TNFα: 316.13 ± 7.62 EU/mL vs. 355.59 ± 8.10 EU/mL, p < 0.01; IL-6: 51.78 ± 2.35 EU/mL vs. 58.98 ± 2.59 EU/mL, p < 0.01) and metabolic endotoxemia (2.83 ± 0.42 EU/mL vs. 0.68 ± 0.14 EU/mL, p < 0.01). These results suggest that apple-derived pectin could modulate gut microbiota, attenuate metabolic endotoxemia and inflammation, and consequently suppress weight gain and fat accumulation in diet induced obese rats.
A Pre and Post Survey to Determine Effectiveness of a Dietitian-Based Nutrition Education Strategy on Fruit and Vegetable Intake and Energy Intake among Adults
Authors: Pem Dhandevi , Bhagwant Suress , Jeewon Rajesh
Published: February 2016

The purpose of the study was to evaluate the effectiveness of a multicomponent nutrition education program among adults. A pretest—posttest design was used assessing Nutritional Knowledge (NK), BMI, Energy Intake (EI), Physical Activity Level (PAL), Dietary Intake (DI) and attitudes. 353 adults aged 19–55 years (178 control group (CG) and 175 intervention group (IG)) were recruited. IG participants attended nutrition education sessions evaluated through a post-test given at the end of the 12-week program. Statistical tests performed revealed that compared to CG, participants in IG increased fruit intake and decreased intake of snacks high in sugar and fat significantly (p < 0.05). NK and attitudinal scores also increased significantly in the IG (p < 0.05). No intervention effect was found for vegetables intake, EI, BMI and PAL (p > 0.05). Factors influencing NK were age, gender and education level. “Taste” was the main barrier to the application of the nutrition education strategy. Findings are helpful to health practitioners in designing their intervention programs.
A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli
Authors: Waldhuber Anna , Snyder Greg , Römmler Franziska , Cirl Christine , Müller Tina , Xiao Tsan , Svanborg Catharina , Miethke Thomas
Published: February 2016

The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters.
Experimentation and Modeling of the Tension Behavior of Polycarbonate at High Strain Rates
Authors: Xu Yingjie , Gao Tenglong , Wang Jun , Zhang Weihong
Published: February 2016

A comprehensive understanding of the mechanical behavior of polycarbonate (PC) under high-rate loadings is essential for better design of PC products. In this work, the mechanical behavior of PC is studied during tensile loading at high strain rates, using a split Hopkinson tension bar (SHTB). A modified experimental technique based on the SHTB is proposed to perform the tension testing on PC at rates exceeding 1000 s−1. The effect of strain rates on the tension stress–strain law of PC is investigated over a wide range of strain rates (0.0005–4500 s−1). Based on the experiments, a physically based constitutive model is developed to describe the strain rate dependent tensile stress–strain law. The high rate tensile deformation mechanics of PC are further studied via finite element simulations using the LSDYNA code together with the developed constitutive model.
Mineral Resources: Reserves, Peak Production and the Future
Authors: Meinert Lawrence , Robinson Gilpin , Nassar Nedal
Published: February 2016

The adequacy of mineral resources in light of population growth and rising standards of living has been a concern since the time of Malthus (1798), but many studies erroneously forecast impending peak production or exhaustion because they confuse reserves with “all there is”. Reserves are formally defined as a subset of resources, and even current and potential resources are only a small subset of “all there is”. Peak production or exhaustion cannot be modeled accurately from reserves. Using copper as an example, identified resources are twice as large as the amount projected to be needed through 2050. Estimates of yet-to-be discovered copper resources are up to 40-times more than currently-identified resources, amounts that could last for many centuries. Thus, forecasts of imminent peak production due to resource exhaustion in the next 20–30 years are not valid. Short-term supply problems may arise, however, and supply-chain disruptions are possible at any time due to natural disasters (earthquakes, tsunamis, hurricanes) or political complications. Needed to resolve these problems are education and exploration technology development, access to prospective terrain, better recycling and better accounting of externalities associated with production (pollution, loss of ecosystem services and water and energy use).
Fuzzy Classification for Shoreline Change Monitoring in a Part of the Northern Coastal Area of Java, Indonesia
Authors: Dewi Ratna , Bijker Wietske , Stein Alfred , Marfai Muh
Published: February 2016

This study presents an unsupervised fuzzy c-means classification (FCM) to observe the shoreline positions. We combined crisp and fuzzy methods for change detection. We addressed two perspectives of uncertainty: (1) uncertainty that is inherent to shoreline positions as observed from remote sensing images due to its continuous variation over time; and (2) the uncertainty of the change results propagating from object extraction and implementation of shoreline change detection method. Unsupervised FCM achieved the highest kappa (κ) value when threshold (t) was set at 0.5. The highest κ values were 0.96 for the 1994 image. For images in 2013, 2014 and 2015, the κ values were 0.95. Further, images in 2003, 2002 and 2000 obtained 0.93, 0.90 and 0.86, respectively. Gradual and abrupt changes were observed, as well as a measure of change uncertainty for the observed objects at the pixel level. These could be associated with inundations from 1994 to 2015 at the northern coastal area of Java, Indonesia. The largest coastal inundations in terms of area occurred between 1994 and 2000, when 739 ha changed from non-water and shoreline to water and in 2003–2013 for 200 ha. Changes from water and shoreline to non-water occurred between 2000 and 2002 (186 ha) and in 2013–2014 (65 ha). Urban development in flood-prone areas resulted in an increase of flood hazards including inundation and erosion leading to the changes of shoreline position. The proposed methods provided an effective way to present shoreline as a line and as a margin with fuzzy boundary and its associated change uncertainty. Shoreline mapping and monitoring is crucial to understand the spatial distribution of coastal inundation including its trend.
Noise Localization Method for Model Tests in a Large Cavitation Tunnel Using a Hydrophone Array
Authors: Park Cheolsoo , Kim Gun-Do , Park Young-Ha , Lee Keunhwa , Seong Woojae
Published: February 2016

Model tests are performed in order to predict the noise level of a full ship and to control its noise signature. Localizing noise sources in the model test is therefore an important research subject along with measuring noise levels. In this paper, a noise localization method using a hydrophone array in a large cavitation tunnel is presented. The 45-channel hydrophone array was designed using a global optimization technique for noise measurement. A set of noise experiments was performed in the KRISO (Korea Research Institute of Ships & Ocean Engineering) large cavitation tunnel using scaled models, including a ship with a single propeller, a ship with twin propellers and an underwater vehicle. The incoherent broadband processors defined based on the Bartlett and the minimum variance (MV) processors were applied to the measured data. The results of data analysis and localization are presented in the paper. Finally, it is shown that the mechanical noise, as well as the propeller noise can be successfully localized using the proposed localization method.
Digital Elevation Model Differencing and Error Estimation from Multiple Sources: A Case Study from the Meiyuan Shan Landslide in Taiwan
Authors: Hsieh Yu-Chung , Chan Yu-Chang , Hu Jyr-Ching
Published: February 2016

In this study, six different periods of digital terrain model (DTM) data obtained from various flight vehicles by using the techniques of aerial photogrammetry, airborne LiDAR (ALS), and unmanned aerial vehicles (UAV) were adopted to discuss the errors and applications of these techniques. Error estimation provides critical information for DTM data users. This study conducted error estimation from the perspective of general users for mountain/forest areas with poor traffic accessibility using limited information, including error reports obtained from the data generation process and comparison errors of terrain elevations. Our results suggested that the precision of the DTM data generated in this work using different aircrafts and generation techniques is suitable for landslide analysis. Especially in mountainous and densely vegetated areas, data generated by ALS can be used as a benchmark to solve the problem of insufficient control points. Based on DEM differencing of multiple periods, this study suggests that sediment delivery rate decreased each year and was affected by heavy rainfall during each period for the Meiyuan Shan landslide area. Multi-period aerial photogrammetry and ALS can be effectively applied after the landslide disaster for monitoring the terrain changes of the downstream river channel and their potential impacts.