bluuebunny/crossref_metadata_2025 huggingface dataset:
Formação de Professores: Pensando a Inclusão do Aluno com Deficiência
Authors: De Magalhães Fabiana Gomes , Costa Kamila Reginaldo
Published: February 2020

O presente estudo é fruto do intercruzamento de discussões iniciadas ao longo do Curso de Pedagogia durante as aulas de Sistema Braile Grau I de Leitura e Escrita e aprofundadasnas discussões suscitadas a partir das pesquisas desenvolvidas nos grupos de estudos do Núcleo de Estudos e Pesquisas em Educação e Diversidade da Faculdade de Educação da Universidade Federal de Juiz de Fora (NEPED/FACED/UFJF). Neste texto, respondemos ao nosso objetivo de refletir sobre a formação de professores voltada para a inclusão do aluno com deficiência tendo como foco a promoção da prática educacional inclusiva. Para subsidiar tal discussão procura-se analisar as propostas de políticas públicas para o ensino superior referente à Educação Inclusiva, buscando, com isso, a construção de redes de conhecimentos sobre sua incorporação nos cursos de formação docente e suas implicações para a educação, sobretudo, do aluno com deficiência. Neste texto temos o objetivo de pensar em meios de fazer com que a competência e a confiança dos docentes em vencer desafios sejam resgatadas de modo que assumam o compromisso com a cidadania e transformação social. Por último e não menos importante, refletir sobre os cursos de formação de professores como lugar onde as diferenças sejam respeitadas, o isolamento, o estigma e os preconceitos sejam superados.
Processo de Bolonha e internacionalização do ensino superior
Authors: Sobral Maria Neide , Ramos Natália
Published: February 2020

A declaração de Bolonha (1999) foi um marco no âmbito das políticas de Educação superior da união Europeia na construção de um modelo educativo que tem assumido características internacionais. Os programas de intercâmbios, mobilidade de estudantes, professores e pessoal administrativo e a integração das Tecnologias da Informação e Comunicação à Educação têm fomentado novos desafios para as universidades. um deles é incorporar a interculturalidade enquanto princípio educativo e comunicacional para dar conta da diversidade cultural de estudantes oriundos de diferentes países. Trata-se de um estudo de natureza bibliográfica e documental com o objetivo de mapear políticas e programas sobre o ensino superior e seu caráter transnacional. além disso, evidenciam-se enunciados sobre o papel da união Europeia na difusão de uma cultura educativa intercultural, com tendência a constituir-se em uma nova ordem educativa mundial.
Cuidar e Educar Criança Pequena para Valores: Um Ato de Amor, Justiça e Bondade
Authors: Dos Santos Maria Souza , Timm Jordana Wruck , De Souza Milena Cristina Aragão Ribeiro
Published: February 2020

Pensar no cuidado e na educação das crianças pequenas é primordial, tendo em vista que toda boa “construção” depende de uma base sólida, o que não difere em nós humanos, sendo na primeira infância a formação dos futuros adultos. O objetivo do artigo é compreender a educação baseada em valores, a fim de desenvolver na criança pequena uma atitude de gradual avanço no sentido da autonomia, da responsabilidade em assumir seu próprio desenvolvimento, buscando uma convivência social harmoniosa, tendo como base os princípios do amor, justiça e bondade. A metodologia empregada consiste nas pesquisas bibliográficas, com a realização de leituras flutuantes em artigos e na busca por referenciais teóricos nos livros, bem como, foram realizadas Rodas de Conversa com o propósito de realizar a coleta de dados. Com as informações obtidas concluímos que há necessidade de profissionais comprometidos com a mudança, dispostos a cuidar e educar para valores, visando uma infância melhor e consequentemente um mundo mais pacífico.
Saberes Pedagógicos na Educação de Jovens e Adultos
Authors: Silveira Maryane Meneses , De Santana Josineide Siqueira , Costa Erivanaldo F. Xavier
Published: February 2020

O presente trabalho de caráter interdisciplinar, elaborado a partir da prática de sala de aula com alunos da Educação de Jovens e Adultos (EJA), reúne metas, metodologias e contribuições da identidade negra; e de como essa população vem produzindo seu espaço seja no campo ou na cidade. Bem como nas relações sociais laborativas, educacionais e culturais existentes na sociedade. Este esboço tem como finalidade facilitar o ensino-aprendizagem através dos conteúdos que foram ministrados sobre história dos povos africanos, dando ênfase aos povos que chegaram ao Brasil e sua contribuição para a formação de nossa sociedade. E orientações de como compartilhar o conhecimento aprendido para os colegas de forma lúdica e explicativa através da confecção de materiais.
Cristianismo e Educação – Uma abordagem histórica da pedagogia da catequese
Authors: Mittaraquis Léo Antonio Perrucho
Published: February 2020

Ao longo da história do Ocidente, uma mentalidade, ou seja, um conjunto de manifestações (crenças, maneira de pensar, disposições psíquicas e morais), que caracterizam tanto uma coletividade, como um indivíduo foi consolidada em diversos aspectos, mas, principalmente nos que se referem à formação religiosa e intelectual, vale dizer, um conjunto de conhecimentos e habilidades específicos a determinados campos de atividade prática e espiritual, baseados na filiação a um sistema específico de pensamento ou crença que envolve uma posição filosófica, ética, metafísica. A esta, mentalidade deu-se o nome de cristianismo. No âmbito dessa doutrina, inúmeras linhas de pensamento foram desenvolvidas. Interessa, como objeto no presente estudo, o pensamento das ordens religiosas no tocante às praticas pedagógico--catequéticas.
Educação superior militar: características no período de 1960 a 1980
Authors: Soffner Renato Kraide , Kirsch Deise Becker
Published: February 2020

Este trabalho analisa o modelo educacional militar brasileiro, caracterizado por um sólido e marcante enfoque tecnicista, no período que se inicia na década de 1960 e vai até os anos de 1980. O objetivo desta investigação é discutir criticamente as práticas educativas desenvolvidas nas escolas militares, as características do ensino, dos alunos e dos professores. Dentre os autores utilizados no referencial teórico estão os estudos de Oliveira (2001;2004), Castro (2004), Baquim (2008), Kirsch (2013), bem como as obras de Turra (1985), Ludwig (1998) e Saviani (2010). Conclui-se que o modelo tecnicista na educação militar restringe a formação do oficial de carreira das forças armadas ao fazer técnico, sem considerar a importância desse profissional não somente em tempos de guerra, mas inserido numa sociedade democrática e em tempos de paz, o que seria importante contemplar numa formação integral do sujeito.
Modelos de saúde e estética: uma análise das capas da revista Playboy brasileira em 2012
Authors: Pimentel Robson Chagas , Baptista Tadeu João Ribeiro
Published: February 2020

O modelo de corpo que é socialmente compreendido como belo e saudável apresenta as características que são necessárias ao modo de produção em vigor. Este, por sua vez, utiliza uma série de estratégias para a disseminação do padrão considerado ideal, sendo o mesmo, difundido pela mídia gestada a partir da lógica da Indústria Cultural. Assim sendo, o objetivo deste texto é analisar a partir das capas da Revista Playboy de 2012, como a Indústria Cultural dissemina um modelo de saúde e beleza, tanto para homens como para mulheres. Como metodologia, adotamos a análise documental dos doze números desta revista que foi publicado em 2012. Os dados mostram que as modelos das capas são brancas, predominantemente jovens e com cabelos loiros e, com níveis de Índice de Massa Corporal (IMC) de uma pessoa magra. A conclusão demonstra que a Revista Playboy, contribui para a disseminação de um modelo de corpo considerado em sua aparência, belo e saudável.
Consciência, consciência corporal e educação fisica
Authors: Melo José Pereira de
Published: February 2020

As tentativas empreendidas para compreender o que significa consciência e consciência corporal levam-nos a um mundo de múltiplas facetas e diversificados discursos, mostrando-nos a complexidade que envolve seus estudos, bem como o aumento no fascínio que essa busca promove. Nesse sentido, o presente artigo tem o propósito de apresentar uma incursão conceitual sobre os termos consciência e consciência corporal, bem como apresentar quais as orientações teórico-metodológicas que orientaram a Educação Física brasileira no trabalho com as práticas alternativas, principalmente na escola.
A dança na arte e na educação física: diálogos possíveis
Authors: Vieira Marcilio de Souza
Published: February 2020

Tendo como apoio os documentos nacionais das Diretrizes de Bases da Educação Brasileira e Parâmetros Curriculares Nacionais (PCN’s), somados aos discursos de dança nas áreas de Arte e Educação Física, o artigo focaliza os diálogos possíveis entre essa duas áreas de conhecimento partindo de uma abordagem fenomenológica merlaupontyana do mundo vivido. Objetiva identificar a relação entre o conhecimento da dança na Arte e na Educação Física.
Sexualidade e deficiência intelectual: concepções, vivências e o papel da educação
Authors: Vieira Camila Mugnai , Coelho Marili André
Published: February 2020

A presente pesquisa buscou compreender as concepções e vivências de sexualidade de jovens com deficiência intelectual por meio de entrevistas individuais com 13 jovens de uma instituição especializada de uma cidade do interior paulista. As entrevistas englobaram conhecimentos prévios e concepções sobre a temática, acesso à educação sexual, relacionamentos afetivos, autoimagem, prazer, etc. Os jovens entrevistados sentiam-se pouco informados sobre a temática da sexualidade e apresentaram vivências de relacionamentos que indicam vulnerabilidade e exposição a situações de riscos tanto no âmbito biológico quanto psicossocial, o que evidencia a necessidade de intervenções sobre o tema e ampliação de ações no âmbito da Educação Sexual.
Como as relações CTS são evidenciada nos textos complementares dos livros de Biologia
Authors: Santana Tainan Amorim , Cardoso Lívia de Rezende
Published: February 2020

Dentro do Ensino de Biologia, o Movimento CTS no currículo preocupa-se em estimular a tomada de atitudes pelo aluno, levando-o a participar da sociedade contemporânea. Sabe-se que os professores utilizam o livro didático como o instrumento principal que orienta o conteúdo a ser administrado. Tais ponderações em torno das interações CTS tornam-se ainda mais pertinentes quando se considera o contexto do livro didático. Assim, objetiva-se analisar as relações CTS existentes nos textos complementares dos volume 1, 2 e 3 da coleção Biologia Hoje, voltada para o Ensino Médico. Para isso, selecionou os textos complementares presentes nos 3 volumes e foram lidos na íntegra, observando os aspectos que os compunham. Diante disso, revelou-se que dos 176 textos analisados, 64 deles ocorreu a prevalência de aspectos científicos, 19 de aspectos sociais e apenas 1 retratou aspectos tecnológicos. Quando observamos a prevalência da interação entre os aspectos que compõem a tríade CTS, verificamos que apenas 3 dos 176 textos complementares se enquadravam na perspectiva CTS. Assim, percebe-se a necessidade de reconstruir para essa linha os livros didáticos produzidos no país, uma vez que, o enfoque CTS ajuda a tornar o aluno um elemento ativo no processo de ensino e aprendizagem.
A construção do sentido em um texto multimodal: análise de anúncio publicitário divulgado na internet
Authors: Pereira Ângela Maria , Bueno Luzia
Published: February 2020

Este artigo visa a apresentar o resultado da análise de um exemplar de anúncio publicitário veiculado na internet, que teve como foco a construção de sentido em um texto multimodal. A investigação insere-se em uma pesquisa de doutorado que está sendo realizada no Programa em Educação da Universidade São Francisco, Itatiba/SP e que tem como objetivo maior subsidiar a elaboração de materiais didáticos para o ensino de gêneros textuais. O trabalho, ancorado principalmente no quadro teórico do Interacionismo Sociodiscursivo – ISD – (Bronckart, 1999/2003, 2006a), apoia-se ainda em Bakhtin (1992/2003), na teoria de Kress e van Leeuwen (1996/2006) sobre a Gramática do Design Visual (GDV) e nas contribuições de Leal (2011), que propõe o modelo de análise Semiótico Sociointeracional. Os resultados apontaram que prevalece, no material analisado, a presença de imagens como meio de persuasão, ainda que a produção de sentido tenha acontecido a partir da integração de elementos verbais e não verbais em um todo coerente.
Jovens em jogo: jogando para construir e refletir
Authors: Ribeiro Flavia Nizia da Fonseca , Pedrosa Stella Maria Peixoto de Azevedo , Mamede-Neves Maria Apparecida Campos
Published: February 2020

A pesquisa apresentada tem por objetivo conhecer as estratégias usadas pelos jovens quando jogam games e investigar se a imersão em jogos eletrônicos (via computadores) permite a aproximação dos jovens com a linguagem digital favorecendo a sua inclusão digital. Além disso, pretende investigar se, trabalhados de forma psicopedagógica, o jogar permite a construção de um conhecimento que ultrapasse a habilidade em jogá-los. Em sua fase inicial o trabalho de campo está sendo desenvolvido em uma zona favelizada da região norte da cidade do Rio de Janeiro. Uma vez por semana, são desenvolvidas oficinas junto a um grupo de meninos e meninas entre 11 a 14 anos que participam de um projeto mais amplo que oferece diversas atividades. Embora o foco da pesquisa não seja a aprendizagem escolar, há indicações que, transposta para a sala de aula, a dinâmica das oficinas poderia contribuir significativamente para o desenvolvimento do pensamento reflexivo, o que implica positivamente na aprendizagem de conteúdos curriculares.
A singularidade na multiplicidade: crianças e tecnologias móveis na escola no contexto da cultura digital
Authors: Miranda Lyana Thédiga de , Fantin Monica
Published: February 2020

O texto discute a relação entre crianças e tecnologias móveis na escola com objetivo de analisar as múltiplas linguagens e multissensorialidades envolvidas no processo de ensino-aprendizagem na perspectiva da mídia- -educação. No contexto de uma investigação sobre o Projeto Um Computador por Aluno (ProUCA) em uma escola pública, desenvolveu-se uma pesquisa com crian- ças, de cunho qualitativo com abordagem metodológica participativa e nuances etnográficas. Tendo como pressuposto os contextos de interação entre educação, comunicação e tecnologias móveis, o artigo discute o modelo um-a-um em diálogo com a noção de ecossistema comunicativo e reflete sobre as possibilidades de uso e apropriação da tecnologia a partir de uma experiência didática desenvolvida com crianças na escola. Por fim, destaca-se a necessidade de pensar as mediações educativas contemporâneas na perspectiva das multiliteracies e de novas metodologias de ensino-aprendizagem.
Práticas de multiletramentos com laptops educacionais
Authors: Cavalcante Andrea Pinheiro Paiva , Castro Filho José Aires de , Linhares Ângela Maria Bessa , Junqueira Eduardo S.
Published: February 2020

O presente trabalho apresenta uma prática com suporte de tecnologias digitais experimentada em sala de aula de uma escola participante do Projeto Um Computador por Aluno (UCA) na perspectiva da Pedagogia dos Multiletramentos e da Educomunicação. O estudo acompanhou alunos do 6º ano em uma atividade de produção de slides, referenciada pelos estudantes como sendo uma das mais significativas realizadas na escola. Tal evento pode ser considerado como de multiletramento pelo uso de imagens e textos com significados diversos e ricos atribuídos pelos estudantes.
Anterior Glenohumeral Instability in the Adolescent Athlete
Authors: Parvaresh Kevin C. , Vargas-Vila Mario , Bomar James D. , Pennock Andrew T.
Published: February 2020

» Glenohumeral instability is multifactorial and has both static and dynamic elements.

» The initial management of first-time dislocations has become increasingly controversial, although recent evidence supports operative treatment for adolescents who participate in contact sports.

» Risk factors for recurrent glenohumeral instability include adolescent age, hyperlaxity, glenoid bone loss, off-track Hill-Sachs lesions, and fixation with ≤3 anchors.

» High rates of return to sport can be expected when the surgical plan is tailored to individual pathology.
Nerve Injuries with the Direct Anterior Approach to Total Hip Arthroplasty
Authors: Vajapey Sravya P. , Morris Jesse , Lynch Daniel , Spitzer Andrew , Li Mengnai , Glassman Andrew H.
Published: February 2020

» While no single approach for total hip arthroplasty (THA) has been proven to be superior to others in terms of patient outcomes, the direct anterior approach (DAA) is becoming increasingly popular.

» All of the described techniques for THA carry a small risk of nerve injury.

» Identifying risk factors for nerve injury and mitigating these risks where feasible are imperative in order to reduce the incidence of this complication with any approach for THA.
Kesiapan Sekolah dalam Mengimplementasikan Kurikulum 2013 (Studi Kasus di Beberapa SD di Kecamatan Palu Barat dan Palu Timur Kota Palu)
Authors: Rahman Abdul , Bahar Syamsul
Published: February 2020

Penelitian ini bertujuan untuk mendeskripsikan dan menganalisis kesiapan sekolah dalam implementasi Kurikulum 2013 di sekolah dasar di Kota Palu. Jenis penelitian ini adalah deskriptif dengan desain studi kasus. Teknik pengumpulan data yang digunakan metode kuisioner dengan teknik analisis data deskriptif persentase. Keabsahan data penelitian ini menggunakan triangulasi sumber dan teknik. Penelitian ini dilaksanakan pada sepuluh sekolah di kota Palu yaitu lima sekolah di Kecamatan Palu Barat dan lima sekolah di Palu timur. Jumlah responden dalam penelitian ini adalah 53 guru dan 42 siswa. Hasil penelitian ini menunjukan bahwa kesiapan sekolah dalam melaksanakan kurikulum  2013 adalah sebagai berikut: 1) Kesiapan guru dalam melaksanakan kurikulum 2013 sudah berjalan dengan baik melihat dari hasil persentase yang tinggi yaitu 79,40% dengan kategori tinggi. 2) Kesiapan siswa dalam melaksanakan kurikulum 2013 sudah berjalan dengan baik melihat dari hasil persentase yang tinggi yaitu 75,25% dengan kategori tinggi. 3) Kesiapan sarana prasarana dalam melaksanakan kurikulum 2013 sudah berjalan dengan baik melihat dari hasil persentase yang sangat tinggi yaitu 73,25% dengan kategori tinggi. 4) Kesiapan kepala sekolah dalam melaksanakan kurikulum 2013 sudah berjalan dengan baik melihat dari hasil persentase yang tinggi yaitu 80,50% dengan kategori tinggi. 5) Kesiapan buku guru dan buku siswa dalam melaksanakan kurikulum 2013 sudah berjalan dengan baik melihat dari hasil persentase   yang   sangat   tinggi   yaitu   87,7% % dengan kategori sangat tinggi
Penerapan Pembelajaran Bioentrepreneurship untuk Meningkatkan Life Skills dan Minat Wirausaha Siswa SMK
Authors: Aqil Deden Ibnu , Hudaya Adeng , Arifin Zainal
Published: February 2020

The application of learning in schools emphasizes students get knowledge from their experience directly. Most of the graduates of vocational students do not go to college but the desire or interest of students for entrepreneurship is very low, therefore schools must equip students with life skills to prepare them to face life after they graduate from school. The problem of this study is how to approach the application of biointrenrenship learning to vocational students to improve life skills and interest in student entrepreneurship. This research is a research development (R & D). Development of learning oriented bioentrepreneurship and tested experimental class. Data was taken by observation, questionnaire and test. Data analysis method used descriptive percentage of life skills scores and questionnaires then analyzed by paired samples test. From the results of the study, there was an increase in interest in entrepreneurship and life skills of students before and after the application of bio-entrepreneurship learning.
Peranan Orang Tua Terhadap Tingkat Penggunaan Media Online Remaja di Jakarta
Authors: Witoro Johanes
Published: February 2020

Tidak bisa dipungkiri, pengaruh positif dan juga negatif dari media online bisa mempengaruhi emosi, intelektual, dan psikologi anak-anak remaja masa kini. Disinilah dibutuhkan peranan orang tua, terutama dalam membentengi dan mengatasi pengaruh-pengaruh negatif dari media online yang ada saat ini. Penelitian ini dimaksudkan untuk mencari hubungan antara peran orang tua terhadap anak remaja mereka yang menggunakan media online dalam kehidupan sehari-hari mereka. Peran orang tua yang siginifikan diharapkan mampu mengtasi pengaruh negatif anak-anak remaja saat ini.Penelitian ini menggunakan metode kuantitatif, yang melibatkan siswa-siswi di sekolah menengah atas sebagai responden utama. Pengambilan data melaui kuisoner yang diberikan kepada siswa-siswi di sekolah menengah atas.Dapat disimpulkan bahwa peranan orang tua memiliki pengaruh yang signifikan dalam penggunaan media online oleh siswa-siswi di sekolah menengah atas. Maka dari itu, diperlukan kerjasama dari orang tua di rumah dan guru di sekolah, dan juga pelibatan anak remaja dalam menghadapi pengaruh negatif media online saat ini.
Yvonne McEwen. In the Company of Nurses: The History of the British Army Nursing Service in the Great War.
Authors: Toman Cynthia
Published: February 2020

Review of Yvonne McEwen. In the Company of Nurses: The History of the British Army Nursing Service in the Great War.
Alison Chand. Masculinities on Clydeside: Men in Reserved Occupations During the Second World War.
Authors: Peniston-Bird Corinna
Published: February 2020

Review of Alison Chand. Masculinities on Clydeside: Men in Reserved Occupations During the Second World War.
R. Andrew McDonald. The Sea Kings: The Late Norse Kingdoms of Man and the Isles, c. 1066–1275.
Authors: Poole Amy
Published: February 2020

Review of R. Andrew McDonald. The Sea Kings: The Late Norse Kingdoms of Man and the Isles, c. 1066–1275.
A Modern Bannatyne
Authors: Hinnie Lucy
Published: February 2020

This essay introduces the Bannatyne Manuscript as an historical and literary artefact and describes the process through which it is being digitized. The importance of this project lies in its goal of making this important manuscript more easily accessible. In addition to discussing the method behind the manuscript’s digitization, it also examines issues related to the creation of digital editions more broadly while examining the editorial process behind the manuscript’s creation by George Bannatyne.
Mapping the Scottish Reformation
Authors: Brock Michelle , Langley Chris
Published: February 2020

This article introduces readers to Mapping the Scottish Reformation, a digital prosopography of ministers who served in the Church of Scotland between the Reformation Parliament of 1560 to the Revolution in 1689. By extracting data from thousands of pages of ecclesiastical court records held by the National Records of Scotland, Mapping the Scottish Reformation (MSR) tracks clerical careers, showing where they were educated, how they moved between parishes, their age, their marital status, and their disciplinary history. This early modern data drives a powerful mapping engine that will allow users to build their own searches to track clerical careers over time andspace. In short, Mapping the Scottish Reformation puts clerical careers – and, indeed, Scottish religious history more generally – quite literally on the map.
Greetings from Scotland:
Authors: James Kevin , McAfee Melissa , Bhattacharjee Aritra , Kurceba Alexandra , Robertson Ainsley
Published: February 2020

This article describes the background behind and the process of the digitization of travel ephemera contained within the University of Guelph’s Scottish Studies Collection. Developed as an experiential learning opportunity for undergraduate students at the University of Guelph, this project explores the place that postcards held in nineteenth- and twentieth-century Scotland, the technologies involved with the printing and creation of postcards, their intended purpose, and what can be learned about Victorian, Edwardian, and postwar society based on postcard design, descriptions, and use. Through the creation of an Omeka online exhibit, those involved with this digitization project were able to share their analysis with the public, while making these materials digitally available for consultation and review.
“Ours is a Court of Papers”: Exploring Scotland and the British Atlantic World using the Scottish Court of Session Digital Archive Project
Authors: Ambuske James
Published: February 2020

This essay describes the Scottish Court of Session Digital Archive Project (SCOS), a multi-institutional collaborative research initiative into Early America and the British Atlantic world. Developed by the digital scholarship team at the University of Virginia Law Library, in partnership with colleagues at the University of Edinburgh, SCOS explores everyday life in the eighteenth and early nineteenth centuries through Session Papers, the printed documents submitted to Scotland’s supreme civil court during litigation. The project provides scholars, genealogists, and the public with open-access digital copies of Session Papers held by the UVA Law Library, the Library of Congress, and other institutional partners. By digitizing these documents, contextualizing them with comprehensive metadata, and providing users with interpretative entry points, SCOS is designed to foster new research on this formative period of Scottish, British, and American history.
Errata & Corrigenda to IRSS 43 (2018)
Authors: Baer-Tsarfati Lisa
Published: February 2020

Changes made to the online version of Volume 43 (2018).
Transduction of Cultured Cells with Recombinant Lentiviral Particles
Authors: Faber Samantha C. , Vitucci Eva C.M. , McCullough Shaun D.
Published: February 2020

This protocol describes the transduction of cultured cells with recombinant lentivirus expressing fluorescent markers. The attached methods document is a formal version of the information included here.Disclaimer: The contents of this article have been reviewed by the US Environmental Protection Agency and approved for publication and do not necessarily represent Agency policy. Mention of trade names or commercial products does not constitute endorsement or recommendations for use.
Prognostic value of tumor mutation burden in non-small cell lung cancer: A Meta-Analysis and system review
Authors: Author) kun zou(Former Corresponding , Li Li , Yang Shuailong , Author) Zhang Lei(New Corresponding
Published: February 2020

Background: We performed this meta-analysis to assess the prognostic value of tumor mutation burden (TMB) for patients with non-small cell lung cancer (NSCLC). Methods: Tow authors independently searched the studies in PubMed, web of science, Google Scholar, Cochrane library (from inception to November 2019), according to the key words “non-small cell lung cancer”, “tumor mutation burden”, “prognosis”. The studies were set up according to the inclusion/exclusion criteria. The estimate hazard ratio (HR), odds ratio (OR), risk ratio (RR) and their 95% confidence intervals (95% CIs) were set as effect measures. All analyses were performed by STATA 12.0. Results:28 studies were involved in this meta-analysis, high TMB was associated with good overall survival (OS) (HR=0.53; 95% CI: 0.42-0.67, p<0.001), progression-free survival (PFS) (HR = 0.53; 95% CI: 0.46-0.62, p<0.001), durable clinical benefits (RR = 2.27; 95% CI: 1.79-2.89, P<0.001), and object response rate (RR = 2.27; 95% CI: 1.80-2.85; p<0.001) in patients treated with immune checkpoint inhibits (ICIs). For treated with non-ICIs, poor PFS (HR = 1.62; 95% CI: 1.27-2.07, p<0.001) and OS (HR = 1.56; 95% CI: 1.30-1.87, p=0.001) was found in high TMB. Compared with chemotherapy, ICIs treatment alone had better OS (HR = 0.68; 95% CI: 0.56 to 0.82, p<0.001) and PFS (HR = 0.64; 95% CI: 0.55 to 0.76, p<0.001) for patients with high TMB, however, for low TMB patients, no benefit was found in ICIs treatment. TMB was correlated with EGFR status (OR = 0.28; 95% CI: 0.08- 0.95; p= 0.040), ECOG score (OR = 1.79; 95% CI: 1.09-2.92; p=0.021) and smoking history (OR = 6.01; 95% CI: 1.28 - 28.13; p=0.023). Conclusions: TMB was associated with better survival in cancer patients receiving immunotherapy, and worse survival in cancer patients receiving non-ICIs. Compared with chemotherapy, ICIs was more effective in high TMB patients, but not in low TMB patients.
Location of Hospital Waste Disposal Site With FSWARA-GIS-MAIRCA Hybrid Algorithm
Authors: Pirbasti Fatemeh Ramila Heydari , Modiri Mahmoud , Hafashjani Kiamars Fathi , Komijan Alireza Rashidi
Published: February 2020

Background: One of the major environmental issues facing most societies is the management of waste, industrial, medical and hazardous waste. Locating is an activity that analyzes the capabilities of an area in terms of whether the land is suitable for a particular application. The metrics used in location vary by application type, but they are all aligned to select the right location. Choosing the right burial site for waste is the most important step in waste management. Inappropriate burial selection causes contamination of water, soil and air in the area. The ultimate goal is to find the most suitable location that has the least impact on the environment and natural resources around, and is economically the least costly and engineered. Results: In this study, we chose south of Tehran as a case study to implement the FSWARA-GISMAIRCA Hybrid Algorithm. Selecting inappropriate locations for hospital waste disposal site at the southeast of Tehran province is one of the environmental problems of this region causing damage to the environment and pollution of ground waters. Since waste disposal site is the most economic, accepted, and important method in most areas, the present study aimed to locate the hospital waste disposal site at the southeast of Tehran province. Using fuzzy Delphi method, nine criteria (slope, height, soil type, distance from fault, distance from surface water, depth of ground waters, distance from residential areas, distance from hospitals and distance from road) were finally selected as the final criteria. Then, the desired criteria were weighed using the FSWARA and entered the GIS system as information layers to calculate the final maps for the appropriate zones, which eight locations were selected for waste disposal site. Conclusions: Finally, using the MAIRCA method, the selected locations were ranked and finally among these eight locations, the fourth point was selected as the final location for hospital waste disposal site at the southeast of Tehran. According to the desired criteria with 34 degree slope, 1008 meters high, 3.4841 meters distance from fault, 8.4428 meters distance from surface water, 12 meters depth of ground waters, 457 meters distance from residential areas, 6.4749 meters distance from hospitals, and 1598 meters distance from road.
Cardiovascular Disease Prediction from Electrocardiogram by using Machine Learning Method: A Snapshot from the Subjects of the Malaysian Cohort
Authors: Nayan Nazrul Anuar , Hamid Hafifah Ab , Suboh Mohd Zubir , Abdullah Noraidatulakma , Jaafar Rosmina , Yusof Nurul Ain Mhd , Hamid Mariatul Akma , Zubiri Nur Farawahida , Arifin Azwa Shawani Kamalul , Daud Syakila Mohd Abd , Kamaruddin Mohd Arman , Jamal Rahman A
Published: February 2020

Background: Cardiovascular disease (CVD) is the leading cause of deaths worldwide. In 2017, CVD contributed to 13,503 deaths in Malaysia. The current approaches for CVD prediction are usually invasive and costly. Machine learning (ML) techniques allow an accurate prediction by utilizing the complex interactions among relevant risk factors. Results: This study presents a case–control study involving 60 participants from The Malaysian Cohort, which is a prospective population-based project. Five parameters, namely, the R–R interval and root mean square of successive differences extracted from electrocardiogram (ECG), systolic and diastolic blood pressures, and total cholesterol level, were statistically significant in predicting CVD. Six ML algorithms, namely, linear discriminant analysis, linear and quadratic support vector machines, decision tree, k-nearest neighbor, and artificial neural network (ANN), were evaluated to determine the most accurate classifier in predicting CVD risk. ANN, which achieved 90% specificity, 90% sensitivity, and 90% accuracy, demonstrated the highest prediction performance among the six algorithms. Conclusions: In summary, by utilizing ML techniques, ECG data can serve as a good parameter for CVD prediction among the Malaysian multiethnic population.
The prognostic role of tumor-infiltrating lymphocytes in urothelial carcinoma of bladder: A systematic review and meta-analysis
Authors: Yang Zhiqiang , Bai Yujin , Hu Xu , Han Ping
Published: February 2020

Background: Tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment are associated with different prognosis in various malignancies. However, their prognostic impact remains controversial in urothelial carcinoma of bladder (UCB). In this systematic review and meta-analysis, we aimed to investigate the prognostic value of TILs in UCB patients.Methods: A systematic review and meta-analysis was performed using Pubmed, Embase and Cochrane Library. Studies were eligible if they investigated the prognostic value of CD3+, CD4+, CD8+, Foxp3+ lymphocytes or TILs in UCB patients, by time-to-event survival analysis. All studies were appraised for risk of bias using the Quality and Prognosis Studies (QUIPS) criteria. Hazard rations (HRs) with their 95% confidence interval (CIs) from each study were used to generate pooled HRs. Results: A total of 14 studies assessing the impact of TILs on prognostic outcomes in UCB patients were included in final analysis. The pooled analysis indicated a favorable role of CD3+ TILs (HR 0.74 (95% CI 0.62-0.88) for overall survival) and CD8+ TILs (HR 0.46 (95% CI 0.28-0.74) for OS) in the clinical outcomes of UCB, while Foxp3+ TILs were associated with worse survival (HR 2.21 (95% CI 1.47-3.32) for recurrence-free survival). Conclusions: This systematic review and meta-analysis confirmed the favorable prognostic impact of CD3+ and CD8+ tumor-infiltrating T cells in UCB patients and found the association between Foxp3+ TILs and worse survival. Future studies using large cohorts and standardized methodology with regard to tumor subsites, stages and treatment modalities are needed to incorporate TILs with clinical practice.
circ-ANKS1B facilitates osteosarcoma cell proliferation and invasiveness via upregulating Ki-67 expression by sponging miR-149-5p
Authors: Yang Hao , Liu Yujie , Li Chao , Liu Yilin , Zhao Liang , Wang Yuqiang , Zhang Yang , Zhang Min , Wang Limin
Published: February 2020

Background: Mounting evidence has shown that Circular RNAs (circRNAs) are associated with initiation and progression of human cancers. However, the expression and function of circRNAs in the development of osteosarcoma (OS) remain unclear. Methods: In this study, the expression profiles of circRNA circ-ANKS1B in OS were identified through qRT-PCR and in situ hybridization (ISH). The relationships between expression of circ-ANKS1B and clinicopathological features of OS patients was analyzed. Cell proliferation potential, migration and invasion ability of OS cells were evaluated through CCK8, colony formation, transwell and wound healing assays in vitro. Xenograft nude mouse experiment was performed to investigate tumor formation ability in vivo. The downstream regulated microRNA of circ-ANKS1B was proved via qRT-PCR and dual-luciferase reporter. Results: We found expression of circ-ANKS1B was markedly overexpressed in OS cell lines and tumor tissues, and high expression of circ-ANKS1B was correlated with advanced TNM stage and poor prognosis of OS patients. The results of functional experiments showed that depletion of circ-ANKS1B could inhibit proliferation and invasion ability of OS cells in vitro, and tumor formation ability in vivo. Further mechanistic studies revealed that circ-ANKS1B could sponge endogenous miR-149-5p and partially reversed the suppressive effect of miR-149-5p in OS cells. Furthermore, we demonstrated that circ-ANKS1B regulated Ki-67 expression by sponging miR-149-5p. Conclusions: In summary, our data showed that circ-ANKS1B accelerated cell growth and invasion in OS by sponging miR-149-5p and regulating Ki-67.
Preservation and Clinical Study on Involved Teeth with Jaw Cyst
Authors: Niu Gang , Li Qing-ling , Tang Yong-gang , Lv Jing-jing , Lin Li-song , Lu You-Guang
Published: February 2020

Background To assess the efficacy of modified surgery in the preservation of tooth pulp affected by jaw cyst. Methods Fifty-four impacted teeth in 16 cases of jaw cyst treated by our department were selected between September 2015 and October 2016. We observed the pulps' activity in the involved teeth and the efficacy of surgery. Results Out of 54 impacted teeth in 16 patients, after 12-24 months’ follow-up,45 affected teeth recovered well, whereas nine teeth showed adverse symptoms such as redness and swelling in the apical area, fistula, and pain. These symptoms resolved after postoperative root canal therapy. Chewing function was restored well. The bone cavity gradually reduced and finally disappeared, and bone density returned to normal after long-term follow-up. ConclusionPreservation of the involved tooth pulp for the treatment of jaw cyst by performing an improved operation method was effective.
A Pilot Study Comparing Tools for Tracking Implementation Strategies and Treatment Adaptations
Authors: Walsh-Bailey Callie , Palazzo Lorella G. , Jones Salene M. W. , Mettert Kayne D. , Powell Byron J. , Stirman Shannon Wiltsey , Lyon Aaron R. , Rohde Paul , Lewis Cara C
Published: February 2020

Background Tailoring implementation strategies and adapting treatments to better fit the local context may improve their effectiveness. However, there is a dearth of valid, reliable, pragmatic measures that allow for the prospective tracking of strategies and adaptations according to reporting recommendations. This study describes the development and pilot testing of three tools to designed to serve this purpose. Methods Measure development was informed by two systematic reviews of the literature (implementation strategies, treatment adaptation). The three resulting tools vary with respect to the degree of structure (Brainstorming Log = low, Activity Log = moderate, Detailed Tracking Log = high). To prospectively track treatment adaptations and implementation strategies, three stakeholder groups (treatment developer, implementation practitioners, mental health providers) were randomly assigned one tool per week via an anonymous web-based survey for nine weeks and incentivized to participate. Three established implementation outcome measures, the Acceptability of Intervention Measure, Intervention Appropriateness Measure, and Feasibility of Intervention Measure were used to assess the tools. Semi-structured interviews were conducted to gather more nuanced information from stakeholders regarding their perceptions of the tools and the tracking process. Results The three tracking tools demonstrated moderate to good acceptability, appropriateness, and feasibility; the Activity Log was deemed the most feasible of the three tools. Implementation practitioners rated the tools the highest of the three stakeholder groups. The tools took an average of 15 minutes or less to complete. Conclusion This study sought to fill methodological gaps that prevent stakeholders and researchers from discerning which strategies are most important to deploy for promoting implementation and sustainment of evidence-based practices. These tools would allow researchers and practitioners to track whether activities were treatment adaptations or implementation strategies and what barrier(s) each target. These tools could inform prospective tailoring of implementation strategies and treatment adaptations, which would promote scale out and spread.
Tight junction protein ZO-1 in Kawasaki disease
Authors: Lai Wan-Tz , Huang Ying-Hsien , Lo Mao-Hung , Kuo Ho-Chang
Published: February 2020

BackgroundKawasaki disease (KD) is a form of systemic febrile vasculitis that can be complicated by coronary artery lesions (CAL). A murine model of KD vasculitis showed that the vasculitis depended on intestinal barrier dysfunction, as well as that the tight junctions maintain the intestinal barrier. In this study, we aimed to investigate the role of tight junction Zonula occludens-1 (Zo-1) in intravenous immunoglobulin (IVIG) treatment response and the occurrence of CAL formation in KD patients.MethodsForty KD patients, 12 healthy controls, and 12 febrile controls were enrolled in this study. Tight junction ZO-1 levels were measured in sera by enzyme-linked immunosorbent assay.ResultsThe serum Zo-1 level was higher in the fever control group but did not achieve statistical significance. Patients who received a second dose of IVIG due to a failure to respond to the initial IVIG treatment had a higher serum tight junction Zo-1 level, but also without statistical significance (p value =0.0582). Patients who developed a coronary artery lesion had a lower serum tight junction Zo-1 level with statistical significance (p value =0.0275).ConclusionsTight junction ZO-1 levels decrease in KD patients with coronary artery lesions and are associated with the intestinal barrier dysfunction of Kawasaki disease and the occurrence of CAL in KD patients.
Long non-coding RNA HAGLR inhibits growth and metastasis and reduces stemness of lung cancer cells through the microRNA-330-3p/SLC34A2 axis
Authors: Yang Chunxia , Chen Dukai , Zhong Xiaoling , Yang Fangding
Published: February 2020

Background Lung cancer (LC) remains a leading cause of cancer-related mortality worldwide. Long noncoding RNAs (lncRNAs) are crucial regulatory molecules in diverse pathological processes, including cancer progression. This study was conducted to probe the influence of lncRNA HAGLR on the growth, metastasis and stemness of LC cells. Methods Aberrantly expressed lncRNAs in LC tissues were screened out using microarray analysis. HAGLR expression in LC tissues and cells and in the paired normal ones was determined using RT-qPCR. Overexpression of HAGLR was administrated in H1299 and A549 cells to identify its function in the biological characteristics of LC cells. Sub-cellular localization of HAGLR was determined, and the downstream molecules involved in the HAGLR-mediated events were predicted on a bioinformation system and validated through dual luciferase reporter gene assay. Results HAGLR was poorly expressed in both LC tissues and cells. Overexpression of HAGLR inhibited viability, proliferation and metastasis, and reduced the stemness of H1299 and A549 cells. HAGLR up-regulated SLC34A2 expression through sponging miR-330-3p, leading to further inactivation of the Wnt/β-catenin signaling pathway. Artificial activation of the Wnt/β-catenin pathway recovered the viability and promoted metastasis of LC cells inhibited by HAGLR Conclusion HAGLR serves as a competing endogenous RNA for miR-330-3p to upregulate miR-330-3p expression and inactivate the Wnt/β-catenin pathway, leading to inhibited growth and metastasis and reduced stemness of LC cells.
Ground-state energy of a Richardson-Gaudin integrable BCS model
Authors: Shen Yibing , Isaac Phillip , Links Jon
Published: February 2020

We investigate the ground-state energy of a Richardson-Gaudin integrable BCS model, generalizing the closed and open p+ip models. The Hamiltonian supports a family of mutually commuting conserved operators satisfying quadratic relations. From the eigenvalues of the conserved operators we derive, in the continuum limit, an integral equation for which a solution corresponding to the ground state is established. The energy expression from this solution agrees with the BCS mean-field result.
Characteristics of packaged water production facilities in Greater Accra, Ghana: implications for water safety and associated environmental impacts
Authors: Semey Maxwell D. K. , Dotse-Gborgbortsi Winfred , Dzodzomenyo Mawuli , Wright Jim
Published: February 2020

Packaged water (sold in bags or bottles) is widely consumed in many countries and is the main drinking-water source for most urban Ghanaian households. There are, however, few studies of packaged water production. This study aims to assess the source water, treatment, and manufacturing characteristics of sachet water (vended in 500 mL plastic bags), together with point-of-manufacture risks to hygienic production. A sample of 90 sachets was collected of brands sold in four neighbourhoods in Accra, Ghana, their packaging and physical characteristics recorded, and a risk score calculated from these. Production processes were observed at 60 associated sachet factories, producers interviewed, and surrounding neighbourhoods surveyed for contamination hazards. 80% of producers packaged groundwater from boreholes and all treated water via reverse osmosis. Almost all manufacturers (95%) reported site visits by regulators in the previous year and few risks to hygienic production were observed at factories. Sanitary risk scores were 9.2% higher at the seven factories never visited by a regulator, though this difference was not significant (t = 1.81; p = 0.07). This survey suggests most Ghanaian sachet water originates from groundwater and is comparatively safe, though a minority remains unregulated. Groundwater governance policy could support this industry in meeting Greater Accra's growing water demand through the designation of protected municipal wellfields.
Edible seed oil waste: status quo and future perspectives
Authors: Welz P. J.
Published: February 2020

Large volumes of process water and steam are required for extraction and refining of edible seed oils. Water usage in most industries has decreased over the years as increasing emphasis is being placed on water re-use in modern facilities. However, given the size of the edible seed oil industry globally, there is a lack of current quantitative data about water use and wastewater generation. As the world moves towards a circular economy and water becomes more scarce, it is imperative that the industry players provide meaningful input/output data in order to benchmark and identify areas for waste valorization. This review provides data currently available in the public domain on the specific wastewater intake and wastewater generation by the edible seed oil industry, highlighting the need for further data collection. In addition, wastewater quality and current and future wastewater treatment technologies are discussed, as well as the potential for valorization of solid waste and effluent from the industry, and potential avenues for future research.