bluuebunny/crossref_metadata_2025 huggingface dataset:
Experiential Avoidance and Mood State in Bipolar Disorder
Authors: Wenze Susan Jennifer , Kats Danielle M. , Gaudiano Brandon A.
Published: May 2018

Experiential avoidance (EA) has been linked to various negative psychological outcomes and is believed to play a key role in many forms of psychopathology. While EA has been studied in the context of depression, anxiety, posttraumatic stress disorder, and other diagnoses, this study is the first to investigate the role of EA in bipolar disorder (BD). Eight participants in treatment for BD answered questions about mood state and EA twice per day for 60 days, using an ecological momentary assessment (EMA) design. Within-person hierarchical linear modeling analyses revealed that EA was negatively correlated with mood. Although EA did not predict subsequent mood, the reverse was true; EA increased following reports of blunted positive mood. Clinical implications, study limitations, and future research directions are discussed.
El rol de Heráclito en el libro IX de las Vidas de Diógenes Laercio
Authors: Sánchez Castro Liliana Carolina
Published: May 2018

El libro IX de las Vidas de Diógenes Laercio es célebre entre los estudiosos del escepticismo pirrónico; sin embargo, dicho libro también incluye una serie de pensadores que se identifican más con los temas propios de la filosofía natural. Esta situación puede restarle credibilidad a Diógenes Laercio como historiador de la filosofía; no obstante, más que acusarlo de un error grosero, habría que entender la razón de ser de esta disposición de pensadores por parte del doxógrafo. Esto no sólo ayudaría a entender la metodología que se sigue en la construcción y articulación de las Vidas, sino también a comprender el proceder mismo de la doxografía y sus objetivos con las clasificaciones y sucesiones. En la presente ocasión me concentraré en el caso de Heráclito de Éfeso, primer pensador nombrado en el libro IX. Mi exploración buscará hacer patente la razón por la cual la disposición de este autor en particular en el lugar en donde se encuentra supone algunas dificultades para el lector de la obra de Diógenes Laercio. Con todo, intentaré mostrar que hay razones que justifican la presencia de Heráclito no sólo en el libro IX, sino a la cabeza de éste.
Variedade expressiva na literatura agrária romana: descrições anatômicas e preceituações veterinárias no livro III das Geórgicas de Virgílio e no livro VI do De re rustica de Lúcio Júnio Moderato Columela
Authors: Trevizam Matheus
Published: May 2018

Neste artigo, desejamos comparar os modos de Columela e Virgílio escreverem as descrições anatômicas dos animais e algumas prescrições veterinárias em excertos precisos de De re rustica, VI e Geórgicas, III. Assim, enquanto o primeiro autor, compondo no interior da tradição dos antigos tratados em prosa, privilegia a informatividade, Virgílio optou por realizar os mesmos processos textuais, sobretudo, elaborando-os expressivamente.
Três décadas de movimento renovador da educação física: alcançamos a maioridade epistemológica?
Authors: Soares Marta Genú
Published: May 2018

Analisa o conceito de epistemologia e a dimensão da maioridade. Faz breve apreciação da evolução da racionalidade científica em seus avanços e recortes temporais representados em grandes pensadores para articular o pensamento da Educação Física à intervenção sócio-educativa e finaliza com tópicos do cenário atual no campo da produção do conhecimento.
Influência da dança expressiva sobre o equilíbrio corporal em portadores com síndrome de down
Authors: Flores Mariana Imbrunito , Bankoff Antonia Dalla Pria
Published: May 2018

O objetivo deste foi estudar a influência da Dança Expressiva sobre o equilíbrio corporal estático e dinâmico em portadores com Síndrome de Down, de ambos os sexos, faixa etária entre 14 a 19 anos de idade, pertencentes à Fundação Síndrome de Down. Para tanto, foi utilizado um protocolo de Dança Expressiva desenvolvido especialmente para o estudo. Para a análise do equilíbrio corporal foi utilizada a baropodometria. A proposta da Dança Expressiva para os portadores da Síndrome de Down foi além da conscientização corporal e como movimentá-las criativamente. Os resultados comprovaram que a dança tem uma grande influência física e intelectual nos portadores da Síndrome de Down, capaz de melhorar a coordenação, lateralidade, a conscientização corporal, espacial e desenvolver a expressividade, criando uma linguagem individual de movimentar-se e comunicar-se. Diversos fatores externos e internos têm influência sobre o equilíbrio corporal, a dança melhorou a distribuição das cargas plantares, mostrando os pontos de pressões mais definidos e melhores posicionados.
Memórias anatômicas
Authors: Corrêa Aline Jorge , Silva Marcelo Moraes e
Published: May 2018

Assustador, subversivo, abjeto, são palavras que nos ocupam a mente ao ler o poema do Poeta de Necrotério. Situação semelhante ocorre ao ver corpos sendo investigados na mesa de anatomia. Perspicaz o poeta Augusto dos Anjos irá expor a busca incansável do conhecimento, algo que se inicia no cadáver perfazendo-se universalmente todos os recônditos da vida. Soçobrado nessa especulação do ser humano a anatomia sulcará a constituição/delineação do corpo, bem como os processos políticos e pedagógicos necessários para sua instituição na sociedade moderna.
O futebol explica o Brasil
Authors: Almeida Marco Antonio Bettine
Published: May 2018

O futebol é a modalidade esportiva mais popular no Brasil e tem sua origem na Inglaterra, assim como outras como rugby e cricket. O futebol surgiu nos colégios ingleses a partir de adaptações do jogo com bola. O que começou como um jogo informal com finalidade de diversão passou a ter regras oficiais a partir de 1863, pela criação da Foot-ball Association, dando um caráter mais voltado à “seriedade do esporte” do que a “ludicidade do jogo”.
Escola e democracia: teorias da educação, curvatura da vara, onze teses sobre educação e política
Authors: Barbieri Aline Fabiane
Published: May 2018

Saviani inicia o seguinte texto apresentando sua problemática por meio de um questionamento motivador: Como as teorias da educação se posicionam mediante a situação de precariedade e marginalidade na educação? Assim, o autor destaca que essas teorias se posicionam em dois grupos principais, de acordo com o entendimento que elas têm da relação entre educação e sociedade. Um primeiro grupo de teorias, chamado por Saviani de teorias não-críticas, seria aquelas que entendem a educação como instrumento de equalização social e de superação da marginalidade, caracterizando assim o problema da marginalidade como resultado da ignorância, um fenômeno acidental que deve ser corrigido. Nesse grupo de teorias encontram-se a Escola Tradicional, a Escola Nova e a Tecnicista.
Material Balance Applied to Dynamic Reservoir-Surveillance Patterns
Authors: Batycky Rod P. , Thiele Marco R.
Published: May 2018

Determining the remaining spatial oil-saturation distribution or current reservoir-pressure distribution for a mature (water, solvent, CO2) flood is a cornerstone of reservoir management for improving sweep and selecting infill-well locations. Decisions of these types are typically supported by reservoir flow simulation models that have been calibrated to historical injection/production data.

In this paper, we present a novel-pattern material-balance (PatMB) approach to estimating remaining fluids in place as an alternative to flow simulation. First, we use the historical injection/production volumes to solve for streamlines and streamline-derived pattern metrics such as well-allocation factors and injector/producer-pair reservoir pore volumes (PVs). Then, we apply material balance on these volumes over time to estimate the remaining oil in place (ROIP) and pressures at the end of history. Resembling reservoir simulation, the method considers changing well patterns through time, requires a 3D static geological model, and yields 3D saturation distributions of oil, water, and gas. However, unlike reservoir simulation, because historical injected and produced voidage terms are honored, calibration is only possible through the 3D distribution of PV and fluids initially in place.

We present results for the Berrymoor-pattern waterflood and show that the ROIP distribution is a strong function of the original-oil-in-place (OOIP) distribution, well locations, and historical oil, gas, and water production/injection volumes. For this case, the ROIP distribution is almost insensitive to interwell permeability distributions, suggesting that the primary focus when estimating ROIP with the PatMB approach is to ensure a good estimate of OOIP, major flow units, and the correct injection/production data. We also compare our method to reservoir flow simulation for a large water/hydrocarbon miscible flood (HCMF), and we observed that the ROIP maps compare well, with both methods highlighting similar areas for potential infill locations. However, the remaining-gas-in-place maps differed with PatMB, showing a more diffused distribution than flow simulation of the gas. We attribute the difference to the fact that PatMB does not account for transport effects such as separation of the phases caused by density differences.
Phase Behavior in Shale Organic/Inorganic Nanopores From Molecular Simulation
Authors: Jin Bikai , Nasrabadi Hadi
Published: May 2018

Production from shale reservoirs is receiving more attention from the petroleum industry. However, there are many complexities associated with optimal production of shale reservoirs. One complexity is the unclear fluid-phase behavior in shale nanopores. In the shale nanopores, the interaction between the pore wall and fluid molecules can significantly change the fluid-phase behavior from the bulk (unconfined) condition. Therefore, the type of pore material can influence the fluid-phase behavior. There have been several recent efforts to model the confined fluid-phase behavior in shale reservoirs. However, the effect of pore material on fluid-phase behavior in shale reservoirs has not been addressed in the previous studies. In this paper, to have a better understanding of phase diagrams in different shale environments, we perform molecular simulations with three materials (two inorganic minerals and one kerogen) and two types of nanopores (slit and cylinder) to model the confined-phase behavior of pure fluids (methane and propane) and one ternary fluid (C1/C3/nC5). From the pure-fluid simulations in the pores of three diameters (4, 7, and 10 nm), confined liquid densities are decreased, whereas vapor densities are increased in the slit and cylinder pores. When pore diameters are increased, critical points are shifted to low densities and high temperatures. Critical temperature and density under confinement can deviate as high as 15 and 60%, respectively, from the original values in bulk. Molecular simulations are conducted for the ternary fluid in the slit and cylinder pores at 160°F. Under confinement, there is a large shift in the nC5 composition of the vapor phase in the ternary diagrams, whereas only small changes have been observed in the ternary diagrams of liquid phase. The density difference between two phases is reduced. Additional tests are performed at one typical shale temperature (290°F) for this ternary fluid in both nanopore types. Phase separation is observed in the slit-pore tests, although only one phase is formed in the tests of the cylinder pores. Because the cylinder pore has more adsorption surface area compared with the slit pore, a stronger adsorption effect is introduced in all tests of the cylinder pores. Based on the comparison of all results (pure fluids and ternary fluid) from the three materials, the calcite pores provide a stronger confinement effect on fluids, and the other two materials have a similar confinement effect on the phase diagrams.
Salt effects on the dilute solution properties of bototo gum (Cochlospermum vitifolium)
Authors: Martínez Maritza Coromoto , Parra Juan Carlos , Vera Antonio José
Published: May 2018

<span style="line-height: 113%; font-family: 'Times New Roman',serif; font-size: 10pt; mso-fareast-font-family: 'Times New Roman'; mso-font-kerning: 14.0pt; mso-contextual-alternates: yes; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">Salt effects on the dilute solution properties of bototo gum (Cochlospermum vitifolium) were investigated. There were measured the intrinsic viscosities of the polymer under study in water, in NaCl (at different concentrations) and in NaCl, CaCl2 and AlCl3, at the same ionic strength (I = 1), using an Ubbelohde viscometer at 25°C. The Huggins intersection model (R2) is more appropriate to determine the intrinsic viscosity than the Kraemer's equation. This parameter tends to reduce with the increase in the salt concentration and the cation charge. The molecules of C. vitifolium gum exudate in water (solvent Φ) tend to adopt a “random coil” conformation, of great volume and radius, which exist in two regimes: diluted and semi-diluted; in the presence of salts, the coils exist only in a diluted regime where they are separate each other. The macromolecules in water have probably an extended ellipsoid shape but in presence of salts, they change to another more compact, probably spherical, with radii and smaller volumes. The knowledge of the behavior of C. vitifolium gum molecules in dilute solutions is an important criterion for its rational use in various industries
La disfunción familiar como predictor de codependencia en adolescentes mexicanos
Authors: Anaya Acosta Andrea , Fajardo Escoffié Elia Cecilia , Calleja Nazira , Aldrete Rivera Elizabeth
Published: May 2018

Una de las consecuencias de las relaciones disfuncionales en la familia es la codependencia. El objetivo del presente estudio fue evaluar la presencia de codependencia en adolescentes mexicanos y su relación con la disfunción familiar. Se aplicaron tres instrumentos –la Escala de Patrones de Interacción de la Estructura Familiar, la Escala Argentina de Codependencia y el Instrumento de Codependencia–, a 304 estudiantes mexicanos entre 14 y 18 años. La desunión se observó como la característica más relevante en la disfunción familiar; mientras que en la codependencia, los componentes más importantes fueron la confusión emocional y la orientación rescatadora. La desunión, las peleas y la triangulación resultaron predictores significativos de la codependencia por focalización en el otro; la desunión, las jerarquías confusas y la evitación del conflicto predijeron la codependencia por autonegación. Se concluyó que existe relación entre la disfunción familiar y los comportamientos codependientes en los adolescentes.
Productividad de Stevia rebaudiana Bertoni con diferentes láminas de riego e inoculantes microbianos
Authors: Cauich Cauich Rodrigo , Pérez Gutiérrez Alfonso , Lozano Contreras Mónica Guadalupe , Garruña Hernández René , Ruíz Sánchez Esaú
Published: May 2018

Las hojas son el órgano más importante en la planta de Stevia rebaudiana Bertoni, debido a que en ellas se encuentra la mayor cantidad de edulcorante. La emisión de hojas está determinada por el adecuado crecimiento de raíces y la cantidad de agua disponible en el suelo. El objetivo del presente estudio fue evaluar la respuesta de plantas de S. rebaudiana Bert. a cuatro láminas de riego calculadas a partir de la evapotranspiración de referencia (ETo) en interacción con inoculantes microbianos. Los tratamientos consistieron en regar con el 60, 80, 100 y 120% de la ETo estimada con un tanque evaporímetro tipo “A” en plantas previamente inoculadas.  Se evaluaron como inoculantes una mezcla de Bacillus spp. y Azospirillum brasilense, Rhizophagus intraradices y un testigo (sin inocular). Se utilizó un diseño de bloques completos al azar con arreglo bi-factorial y cuatro repeticiones. Se evaluaron parámetros de crecimiento, producción y distribución de biomasa seca, intercambio de gases y uso eficiente del agua. Se encontró diferencia estadística (P≤0.05) por factores separados. Se obtuvo la mejor altura con 120% ETo, aunque fue estadísticamente igual (P≤0.05) a 100% ETo registrando 42.86 y 40.58 cm respectivamente, el 120% ETo se registró mayor área foliar. El tratamiento con Rhizophagus intraradices mostró diferencias significativas (P≤0.05) en la longitud de raíz contra el testigo, pero no contra la mezcla de rizobacterias. De igual forma R. intraradices mejoró el volumen de raíz registrando 2.49 cm3 con respecto al testigo, y permitió reducir un 20% la aplicación de la ETo para obtener la mayor producción de biomasa seca de hoja y raíz. La interacción R. intraradices + 80% ETo favoreció la asimilación del CO2 con 5.41 µmol m-2 s-1, de esta manera se proporcionó mejores condiciones para la transpiración y el uso eficiente del agua (1.87 µmol CO2 mmol-1 H20). El factor riego mostró efecto en la altura, área foliar, diámetro del tallo y rendimiento de hoja seca, mientras que el factor inoculante sólo afectó la longitud de raíz, volumen de raíz, relación MSV/MRS y rendimiento. Por último, la interacción de los dos factores solo fue significativa en los parámetros de producción de biomasa seca e intercambio de gases.
Comparación de técnicas de imputación para tratar respuestas censuradas en un diseño de experimentos bivariado
Authors: Zuñiga Maldonado Cecilia Abigail , Hernández Ripalda Manuel Darío , Jiménez García José Alfredo
Published: May 2018

Introducción: El análisis de diseños de experimentos con respuestas bivariadas puede ser un reto para el investigador, más aún cuando algunos datos de las respuestas están censurados. Chowdhury y Aggarwala (2007) presentaron un conjunto de técnicas para imputar valores a los datos censurados, en este trabajo se comparan esas técnicas. Se utiliza un método propuesto por Chiao y Hamada (2001) para identificar la configuración óptima de parámetros. El caso con los datos que aquí se trata es el reportado por Harper, Kosbe y Peyton (1987) sobre el desequilibrio de un componente de cubierta de rueda de plástico.                        Método: Los datos del experimento no se encuentran censurados originalmente, estos se analizan a fin de tener una base de comparación. Después se implementan criterios para censurar el 16 y 21 por ciento de las respuestas con lo que se generan dos nuevos conjuntos de datos, a estos se aplican las técnicas de imputación: 1) esperanza condicional después de hacer regresión con las respuestas, 2) estadísticas de orden y 3) observaciones simuladas. Para cada conjunto de datos generado se determina la configuración óptima de parámetros (Xopt) y se calcula la suma de cuadrados del error (SCE).       Resultados: Con los datos censurados al 16%, las técnicas de imputación: esperanza condicional iniciando con Y1, estadísticas de orden para Y1 y observaciones simuladas para Y2, generan valores con los que se obtiene una Xopt que concuerda con los datos originales. Con los datos censurados al 21%, ninguna de las técnicas obtiene una Xopt que concuerde con los datos originales. La suma de cuadrados del error de la respuesta 1 (SCE1) de observaciones simuladas para Y2 es significativamente menor comparada con la de los otros métodos. La diferencia entre la SCE2 resultante en todas las técnicas no es considerable.                      Conclusión: Después de comparar la Xopt y los SCE resultantes de los conjuntos de datos imputados con las técnicas mencionadas se puede decir que el método observaciones simuladas para Y2 funciona mejor para tratar las respuestas censuradas del diseño de experimentos bivariado que aquí se trabaja.
Estudio calorimétrico con el uso de termopares en aislante hecho de mezclilla de desecho para viviendas en Saltillo, Coahuila
Authors: Sánchez Terán Luis Fernando , Roux Gutiérrez Rubén Salvador , Espuna Mujica José Adán
Published: May 2018

Introducción: En este artículo se presenta el desarrollo de un aislante térmico para edificios de uso habitacional hecho con material de desperdicio de las empresas maquiladoras de mezclilla asentadas en el municipio de Saltillo, en el estado de Coahuila, México. Se fabricó en forma de panel, procurando su funcionalidad, para que los habitadores de las viviendas puedan reducir el consumo de energía eléctrica mediante el uso de un sistema aislante que permita soportar los estragos del clima y genere mayor confort para el usuario.Método: Cada uno de los prototipos desarrollados fueron expuestos al calor producido por una serie de luminarias incandescentes y a lo largo de 22 horas se estuvo monitoreando el desempeño de cada muestra. Con la ayuda de termopares se obtuvieron las ganancias de calor sobre las caras exteriores (o expuestas a la fuente calórica) y las caras interiores, donde se registraron las temperaturas en las superficies de las mismas mediante el uso de una cámara termográfica.Resultados: Se observó que los diferentes tipos de páneles presentaron una variación en su eficiencia térmica de hasta un 66 %, en comparación con materiales como el BTC (Bloque de Tierra Comprimida) y un 75 % cotejados contra el block de concreto. Se escogió el panel de mejor desempeño, dependiendo de factores como el espesor de las muestras, la cantidad de materia prima que se utilizó y el tiempo de retardo térmico, que en el panel seleccionado fue 20 % más eficiente que en los prototipos restantes.Conclusión: El aislante desarrollado con mezclilla de desecho es capaz de mejorar las condiciones interiores de temperatura en una vivienda en Saltillo, ayudándola a ser más fresca en verano y cálida durante el invierno, además de consumir menos recursos energéticos debido a que es un material producido de desechos que no se aprovechan en ninguna otra área en la actualidad, hecho que contribuye a reducir la contaminación por el exceso de residuos sólidos industriales.
Análisis de la eficiencia productiva del cultivo de alfalfa mediante regresión logística de datos categóricos en el Distrito de Riego 05-Delicias, Chihuahua, México
Authors: Villalobos Cano Octavio , Sánchez Chávez Esteban , Morales Nieto Carlos Raúl , Esparza-Vela Mario Edgar , Santellano Estrada Eduardo
Published: May 2018

Introducción: La alfalfa es la leguminosa más utilizada en la alimentación del ganado a nivel mundial, su alto valor nutritivo, principalmente por su contenido de proteína, lo hacen un ingrediente atractivo para su inclusión en la dieta. El Estado de Chihuahua es el principal productor de alfalfa en México y el Distrito de Riego 05-Delicias ocupa el segundo lugar en la producción de alfalfa de los distritos de riego en el país, con el 18% la producción, pues este cultivo llega a cubrir casi la mitad de su superficie. El objetivo de este trabajo fue determinar el impacto de cuatro factores de producción sobre la eficiencia productiva del cultivo y generar información de utilidad para la toma de decisiones de productores y autoridades.Método: En este estudio se seleccionaron cuatro variables predictoras (factores de producción) en escala dicotómica: Tenencia de la tierra, Propiedad del predio, Maquinaria especializada y Riego tecnificado, para determinar su efecto sobre la eficiencia productiva en el cultivo de alfalfa como variable de respuesta. Para determinar el mejor ajuste del modelo se recurrió al método de selección de variables por pasos hacia atrás (backward), los datos se analizaron bajo un modelo de Regresión Logística utilizando el procedimiento CATMOD del paquete SAS 9.4 y mediante contrastes para la determinación  de los efectos de los factores en las interacciones significativas.Resultados: Se encontró efecto significativo de la triple interacción Propiedad-Maquinaria especializada-Riego tecnificado, así como, en general, de los efectos principales Maquinaria especializada y Riego tecnificado. Al determinar, mediante contrastes, los efectos de las variables dentro de la triple interacción, sobresalió el impacto potencial que produce la existencia de Maquinaria especializada-Riego tecnificado en conjunto, cuando se cuenta con la propiedad del predio con un valor tasa de momios de 16 (número de veces en que se incrementa la probabilidad potencial de alcanzar la eficiencia productiva con estos factores de producción); seguido del efecto de la Maquinaria especializada cuando se tiene la Propiedad, con una tasa de momios de 13.56;  y el efecto del Riego tecnificado, cuando se tiene la Propiedad del predio con una tasa de momios de 8.0.Discusión o Conclusión: La eficiencia productiva del cultivo de alfalfa se explicó de manera significativa por la triple interacción de las variables Propiedad-Maquinaria especializada-Riego tecnificado. Se presentó el máximo efecto cuando se es propietario del predio por el efecto conjunto de Maquinaria especializada-Riego tecnificado. La interacción Maquinaria especializada-Riego tecnificado muestra efecto significativo, pero su impacto fue menor cuando no se es propietario del predio.
Inhaled Micro/Nanoparticulate Anticancer Drug Formulations: An Emerging Targeted Drug Delivery Strategy for Lung Cancers
Authors: Islam Nazrul , Richard Derek
Published: May 2018

Local delivery of drug to the target organ via inhalation offers enormous benefits in the
management of many diseases. Lung cancer is the most common of all cancers and it is the leading
cause of death worldwide. Currently available treatment systems (intravenous or oral drug delivery)
are not efficient in accumulating the delivered drug into the target tumor cells and are usually associated
with various systemic and dose-related adverse effects. The pulmonary drug delivery technology
would enable preferential accumulation of drug within the cancer cell and thus be superior to intravenous
and oral delivery in reducing cancer cell proliferation and minimising the systemic adverse effects.
Site-specific drug delivery via inhalation for the treatment of lung cancer is both feasible and efficient.
The inhaled drug delivery system is non-invasive, produces high bioavailability at a low dose
and avoids first pass metabolism of the delivered drug. Various anticancer drugs including chemotherapeutics,
proteins and genes have been investigated for inhalation in lung cancers with significant outcomes.
Pulmonary delivery of drugs from dry powder inhaler (DPI) formulation is stable and has high
patient compliance. Herein, we report the potential of pulmonary drug delivery from dry powder inhaler
(DPI) formulations inhibiting lung cancer cell proliferation at very low dose with reduced unwanted
adverse effects.
Recent Development of Small Molecule Glutaminase Inhibitors
Authors: Song Minsoo , Kim Soong-Hyun , Im Chun Young , Hwang Hee-Jong
Published: May 2018

Glutaminase (GLS), which is responsible for the conversion of glutamine to glutamate, plays a
vital role in up-regulating cell metabolism for tumor cell growth and is considered to be a valuable therapeutic
target for cancer treatment. Based on this important function of glutaminase in cancer, several
GLS inhibitors have been developed in both academia and industry. Most importantly, Calithera Biosciences
Inc. is actively developing the glutaminase inhibitor CB-839 for the treatment of various cancers,
and it is currently being evaluated in phase 1 and 2 clinical trials. In this review, recent efforts to
develop small molecule glutaminase inhibitors that target glutamine metabolism in both preclinical and
clinical studies are discussed. In particular, more emphasis is placed on CB-839 because it is the only
small molecule GLS inhibitor being studied in a clinical setting. The inhibition mechanism is also discussed
based on X-ray structure studies of thiadiazole derivatives present in glutaminase inhibitor
BPTES. Finally, recent medicinal chemistry efforts to develop a new class of GLS inhibitors are described
in the hopes of providing useful information for the next generation of GLS inhibitors.
Android Library for Recognition of Activities of Daily Living: Implementation Considerations, Challenges, and Solutions
Authors: Pires Ivan Miguel , Teixeira Maria Canavarro , Pombo Nuno , Garcia Nuno M. , Flórez-Revuelta Francisco , Spinsante Susanna , Goleva Rossitza , Zdravevski Eftim
Published: May 2018

Background:

Off-the-shelf-mobile devices have several sensors available onboard that may be used for the recognition of Activities of Daily Living (ADL) and the environments where they are performed. This research is focused on the development of Ambient Assisted Living (AAL) systems, using mobile devices for the acquisition of the different types of data related to the physical and physiological conditions of the subjects and the environments. Mobile devices with the Android Operating Systems are the least expensive and exhibit the biggest market while providing a variety of models and onboard sensors.

Objective:

This paper describes the implementation considerations, challenges and solutions about a framework for the recognition of ADL and the environments, provided as an Android library. The framework is a function of the number of sensors available in different mobile devices and utilizes a variety of activity recognition algorithms to provide a rapid feedback to the user.

Methods:

The Android library includes data fusion, data processing, features engineering and classification methods. The sensors that may be used are the accelerometer, the gyroscope, the magnetometer, the Global Positioning System (GPS) receiver and the microphone. The data processing includes the application of data cleaning methods and the extraction of features, which are used with Deep Neural Networks (DNN) for the classification of ADL and environment. Throughout this work, the limitations of the mobile devices were explored and their effects have been minimized.

Results:

The implementation of the Android library reported an overall accuracy between 58.02% and 89.15%, depending on the number of sensors used and the number of ADL and environments recognized. Compared with the results available in the literature, the performance of the library reported a mean improvement of 2.93%, and they do not differ at the maximum found in prior work, that based on the Student’s t-test.

Conclusion:

This study proves that ADL like walking, going upstairs and downstairs, running, watching TV, driving, sleeping and standing activities, and the bedroom, cooking/kitchen, gym, classroom, hall, living room, bar, library and street environments may be recognized with the sensors available in off-the-shelf mobile devices. Finally, these results may act as a preliminary research for the development of a personal digital life coach with a multi-sensor mobile device commonly used daily.
Bioinformatic Analysis of a “Functional Cluster” Probably Related to Retinitis Pigmentosa
Authors: Donato Luigi , Denaro Lucia
Published: May 2018

Background:

Retinitis pigmentosa is an eye hereditary disease caused by photoreceptor death. One of the biggest problem is represented by its genetic heterogeneity, which has not yet allowed us to found all causative genes and how known ones could influence each other, leading to retinitis etiopathogenesis.

Objective:

To propose the possible relation between the “functional cluster” of vision dark adaptation, made of five phototransductional genes (RCVRN,GNB1,GNGT1,GRK7andARRB1), and retinitis pigmentosa onset.

Methods:

A bioinformatic approach was exploited: the starting point was searching through online database as PubMed and EMBASE to acquire information about the state of art of these gene. This step was followed by an in-silico analysis, performed by softwares as Cytoscape and Genecards Suite Plus, articulated in three phases: I) identification of common pathways and genes involved in; II) collection of previously detected genes; III) deep analysis of intersected genes and implication into etiopathogenesis of analzyed disease.

Results:

The whole in-silico analysis showed that all five gene products cooperate during phototransductional activation, expecially in the dark adaptation. Interestingly, the most exciting aspect regards the direct relation with several known retinitis pigmentosa causative genes, in form of protein interactions or other pathway correlations.

Conclusion:

Pathway analysis permitted us to hypothesize a possible role of analyzed genes in retinitis pigmentosa etiopathogenesis, also considering the key activity of their encoded proteins. Next step will be validating our hypotesis with functional assays to ensure the real meaning of this possible association, leading to new potential retinitis pigmentosa causative genes.
INTRODUCTORY NOTE
Authors: The Editors
Published: May 2018

Ethics, Politics & Society is a new open access academic journal with double blind peer review dedicated to the publication of high level contributions in the fields of Political Philosophy and Theory, as well as Normative and Applied Ethics. Although it is open to all themes and approaches in these areas of knowledge, the journal focuses on issues related to theories of justice, democracy and recognition, as well as on ethical issues connected to scientific and technological development and their social and environmental impacts. Ethics, Politics & Society accepts the submission of originals both with a direct contemporary approach, or using the History of Moral and Political Philosophy to shed light on relevant problems in our time.

This first issue of Ethics, Politics & Society includes an open section and two closed sections that have been nevertheless subject to the same standards of peer-review.  The first open section is composed with original articles submitted by Douglas Giles, Lars Lindblom and Matthew McLennan. The section devoted to the 8th Braga Meetings on Ethics and Political Philosophy opens with the keynote lecture on “The Democratic Boundary Problem Reconsidered” delivered in Braga by Gustaf Arrhenius. This outstanding contribution is followed by a dossier of selected papers presented at the Meetings by Ashley Lane, Josh T. U. Cohen, Deven Burks, Daniel Guillery, Stephen McLeod, and Damiano Simoncelli. This section has been guest edited by Alexandra Abranches and Eze Paez.

The third section consists of a Symposium on Friedrich Hayek and Karl Polanyi. This timely and provocative book discussion that combines readings of The Road to Serfdom and The Great Transformation has been guest edited by António Baptista and Pedro Teixeira, with contributions by António Baião, José Colen and Pedro Moreira, Filipe Nobre Faria, Patrícia Fernandes, Bru Lain, and João Rodrigues.

Ethics, Politics & Society encourages prospective authors to submit their manuscripts in English, Portuguese or Spanish through the journal website, together with the statement that the submitted piece has not been published before and elsewhere. All the papers submitted to Ethics, Politics & Society are subject to the evaluation of at least two reviewers in the corresponding scientific domain. Papers are sent anonymously to blind referees, who are asked to write a review according to the evaluation form adopted by the journal, which includes the following aspects: adequacy to the journal publication standards; adequacy of the paper subject to the scope of the journal; substantive relevance; originality; relevance of the critical methodology; clarity of presentation; arguments and relationship between initial hypotheses and final results.

With the appearance of Ethics, Politics & Society, its editors believe that a clear and urgent lacuna is filled in for an international journal that works as a high-level global forum imprinted with the perspective of Southern Europe.
A MULTIDIMENSIONAL VIEW OF MISRECOGNITION
Authors: Giles Douglas
Published: May 2018

Following Axel Honneth, I accept that recognition is integral to individuals’ self-realization and to social justice and that instances of misrecognition are injustices that cause moral injuries. The change in approach to misrecognition that I advocate is to replace a macrosocial top-down picture of misrecognition, such as Honneth’s typology, with a fine-grained phenomenological picture of multiple dimensions in misrecognition behaviors that offers greater explanatory power. This paper explains why a multidimensional view of misrecognition is needed and explores the various ways that engagement with pathological norms or disengagement from individuals lead to injustices of misrecognition and how understanding behaviors in terms of these two dimensions—norms and individuals—illuminates causes of injustice. The multidimensional view of misrecognition replaces Honneth’s binary view of misrecognition as the contrary to recognition without replacing Honneth’s conceptions of the value of recognition.
COMBINING DEMOCRATIC EQUALITY AND LUCK EGALITARIANISM
Authors: Lindblom Lars
Published: May 2018

The concept of responsibility plays a crucial part in the debate between proponents of democratic equality, like Rawls, and defenders of luck egalitarianism, such as Dworkin. In this paper it is argued that the two theories can be combined, and that they should be combined to achieve a theory of justice that puts personal responsibility in its proper place. The concept of justice requires two different conceptions. The two theories can be combined because they deal with different problems of justice. They ought to be combined because, first, luck egalitarianism needs a theory of background justice, and second, a theory of justice must supply an answer to the question of just individual allocations, something that is not provided by democratic equality. Democratic equality and luck egalitarianism solve each other’s problems. The combined theory will lead to allocations of goods that respect both the difference principle and the envy test.
NORMS FOR THE PUBLIC REMEMBRANCE OF NONHUMAN ANIMALS
Authors: McLennan Matthew
Published: May 2018

This article builds upon Avishai Margalit’s distinction between ethical and moral norms of remembrance. While Margalit is limited by his broadly Kantian framework and restricts his arguments to the remembrance of human beings, the author will argue that the resources exist both in his account and in the particularities of Canadian public life to a) account philosophically for what minimal public ethical norms are in place for the remembrance of nonhuman animals, and b) point towards a more robust, properly moral account of nonhuman animal remembrance. The author will take a recent Canadian case study in the public remembrance of nonhuman animals– the 2012 Animals in War Dedication – to show how existing norms are inherently unstable, pointing beyond themselves to a more species-inclusive, properly moral public perspective.
INTRODUCTION
Authors: Abranches Alexandra , Paez Eze
Published: May 2018

Nine years ago the members of the Political Theory group at the University of Minho (now the Centre for Ethics, Politics and Society) decided to hold the first edition of the Meetings on Ethics and Political Philosophy. It was conceived as a yearly encounter among researchers of the various disciplines in practical philosophy, fostering an amicable discussion among peers which would attract prestigious scholars and provide young researchers with an opportunity to present their work. So far this initiative has been met with success. Its last edition—the eight, in June 2017—gathered more than 68 participants, selected from the more than 162 abstracts that were received.
THE DEMOCRATIC BOUNDARY PROBLEM RECONSIDERED
Authors: Arrhenius Gustaf
Published: May 2018

Who should have a right to take part in which decisions in democratic decision making? This “boundary problem” is a central issue for democracy and is of both practical and theoretical import. If nothing else, all different notions of democracy have one thing in common: a reference to a community of individuals, “a people”, who takes decision in a democratic fashion. However, that a decision is made with a democratic decision method by a certain group of people doesn’t suffice for making the decision democratic or satisfactory from a democratic perspective. The group also has to be the right one. But what makes a group the right one? The criteria by which to identify the members of the people entitled to participate in collective decisions have been surprisingly difficult to pin down. In this paper, I shall revisit some of the problems discussed in my 2005 paper in light of some recent criticism and discussion of my position in the literature, and address a number of new issues.
GENDER IDENTITIES AND FEMINISM
Authors: Cohen Josh T. U.
Published: May 2018

Many feminists (e.g. T. Bettcher and B.R. George) argue for a principle of first person authority (FPA) about gender, i.e. that we should (at least) not disavow people's gender self-categorisations. However, there is a feminist tradition resistant to FPA about gender, which I call "radical feminism”. Feminists in this tradition define gender-categories via biological sex, thus denying nonbinary and trans self-identifications. Using a taxonomy by B. R. George, I begin to demystify the concept of gender. We are also able to use the taxonomy to model various feminist approaches. It becomes easier to see how conceptualisations of gender which allow for FPA often do not allow for understanding female subjugation as being rooted in reproductive biology. I put forward a conceptual scheme: radical FPA feminism. If we accept FPA, but also radical feminist concerns, radical FPA feminism is an attractive way of conceptualising gender.
ARE WE POST-JUSTIFICATION? STOUT’S CASE FOR SELF-KNOWLEDGE, POLITICAL JUSTIFICATION AND PUBLIC PHILOSOPHY
Authors: Burks Deven
Published: May 2018

Must the participant to public discourse have knowledge of her beliefs, attitudes and reasons as well as belief-formation processes to have justified political belief? In this paper, we test this question with reference to Jeffrey Stout’s (2004) approach to public discourse and public philosophy. After defining selfknowledge and justification along the lines of James Pryor (2004), we map thereon Stout’s view of public discourse and public philosophy as democratic piety, earnest storytelling and Brandomian expressive rationality. We then lay out Brian Leiter’s (2016) naturalistic critique of public philosophy as “discursive hygiene” to see whether Stoutian public philosophy survives the former’s emotivist-tribalist gauntlet. Lastly, we find that Leiter’s critique proves less radical than it may appear and requires the moderating influence of a public philosophy like Stout’s. All in all, Stoutian public discourse and public philosophy powerfully illustrates a strong, necessary connection between self-knowledge and political justification. Post-truth is not post-justification.
BASIC LIBERTIES, THE MORAL POWERS AND WORKPLACE DEMOCRACY
Authors: K. McLeod Stephen
Published: May 2018

The article responds to previous work, by Martin O’Neill, about the Rawlsian case for an entitlement to an element of workplace democracy. Of the three arguments for such an entitlement that O’Neill discusses, this article focuses mainly on the one he rejects (on the grounds of its having an implausible premise): the Fundamental Liberties Argument, according to which the right to an element of workplace democracy is a basic liberty. This article argues that while the argument can be improved to withstand O’Neill’s objection, it is invalid. The article sets out a new argument, the Argument from Risk to the Moral Powers. While inspired by the Fundamental Liberties Argument, it is valid. Moreover, its premises are at least as plausible as those of one of the two arguments upon which O’Neill builds his Rawlsian case for an entitlement to an element of workplace democracy.
O CREDO LIBERAL E OS SEUS CRÍTICOS: PAUPERISMO E REDE DE SEGURANÇA
Authors: Baião António , Colen J. A. , Moreira Pedro
Published: May 2018

Em 1944, duas obras marcantes da teoria política, A Grande Em 1944, duas obras marcantes da teoria política, A Grande Transformação e O Caminho da Servidão, apresentam visões quase opostas da relação entre o nascimento do “mercado” e os fascismos: no primeiro caso, o mercado provoca o fascismo como reacção de defesa da sociedade, condenada ao pauperismo, contra o credo liberal; no outro, o mercado é a melhor, senão única defesa da liberdade contra o regresso das tendências totalitárias que asfixiam a liberdade, agora sob a forma da planificação. O texto examina os argumentos dos dois autores, procurando elucidar e discutir as concessões de Hayek à intervenção do estado e explicar porque, posteriormente, ele se inclina a abandonar a proposta de uma rede de segurança que defenderia as vítimas das falhas do mercado.
POLANYI’S ECONOMIC EMBEDDEDNESS, COUNTERMOVEMENT, AND REPUBLICAN POLITICAL ECONOMY
Authors: Lain Bru
Published: May 2018

The aim of this article is to contend that Karl Polanyi’s work bears significant coincidences with the republican tradition of thought. The first of them is one of a methodological or epistemological kind, and it consists of the use of a very similar “social ontology”. The second one is of a substantive sort, and it is related to the “material conditions for freedom” which derive from a very similar conception of freedom and property. In the third section, we propose a republican reading of Polanyi’s work based on three of the author’s primary notions, those of “economic embeddedness”, “double movement”, and “political economy”. The article concludes by arguing that such concepts may prove useful both for understanding the democratic-republican program and for underlining its present validity in contemporary market societies.
Coal Airborne Particulates and its Relationship with Human Health
Authors: Mohd Dina Shamzani Affendy , Nik Yahyab Nik Nurul-Hidayah , Abdullah Alias
Published: May 2018

Airborne particles emitted from coal-fired power plant affects human behaviour. Two times 8 hours airborne particulate personal outdoor sampling through 7-hole and cyclone samplers has been conducted nearby a coal-fired power plant and a gas power plant. Two samplers used were 7-hole and cyclone. This research found that 58.25 per cent (%) from total inhalable dust exceeded the outdoor PM10 DOE 24 hours Malaysia Standard. The study also has found that the percentage ratio of respirable towards inhalable dust is at 51.7%. Finally, effects of coal particles to human health were identified.
Dynamic Visual Therapy for Alzheimer Patients
Authors: Kamaruzaman Muhamad Fairus , Azahari Mustafa Halabi
Published: May 2018

Intervention by using dynamic visual technology can be a persuasive nourishment mechanism in order to enrich the quality of life for individuals with Alzheimer's disease (AD). Interventions that contain reminiscence use the person's creativity and memoirs to implicate them in activities that may offer a variety of aids. Unfortunately, the design of this technology can be a byzantine procedure. The objective of this study is to determine the role of dynamic visual as a form to enhance reminiscence psychoanalysis therapy for the patient with AD. Emphasizing of the subject was done on individuals who suffered mild stage of AD.
Perception on Innovation for Pre-cast Toilet
Authors: Abd. Rahman Nurul Asra , Mohmad Zainordin Zainab , Ahmad Suryani
Published: May 2018

The Hybrid construction method with in-situ concrete used for a toilet in a predominantly pre-cast concrete (PC) structure is a hindrance towards full adoption of Industrialised Building System (IBS). Improved knowledge on a leaking problem can lead to innovative toilet construction. Research objectives are to gauge stakeholders' awareness on leaking problems in PC structure and perception on innovative toilet construction. Research methodology is through case study and structured interviews. The study concludes that improved development of Pre-fabricated Toilet Unit (PTU) is a good solution for the leaking problem in PC structure but it requires consolidated efforts from stakeholders to improve construction industry acceptance.