bluuebunny/crossref_metadata_2025 huggingface dataset:
Autologous adipose-derived stem cells for the treatment of Crohn’s fistula-in-ano: an open-label, controlled trial
Authors: Zhou Chungen , Li Meng , Zhang Yang , Ni Min , Wang Yehuang , Xu Dachao , Shi Yang , Zhang Bo , Chen Yanni , Huang Yan , Zhang Sumin , Shi Hongzhen , Jiang Bin
Published: March 2020

Background

Crohn’s fistula-in-ano is a refractory disease in colorectal and anal surgery. Although autologous adipose-derived stem cell (ADSC) has been used in the treatment of Crohn’s fistula-in-ano because of its convenience, non-incision of normal tissue, good tolerance, repeatability, quick recovery, less pain, less damage to anal function, and high quality of life during the perioperative period, there are no reports of its use in China. This is the first clinical trial in China on the treatment of Crohn’s fistula-in-ano with ADSC to evaluate its efficacy and safety.

Methods

A total of 22 patients with Crohn’s fistula-in-ano were enrolled in this study from January 2018 to October 2018 in the Colorectal Disease Center of Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine. Patients were divided (1:1) into an observation group (ADSC) and a control group (incision-thread-drawing procedure). Primary efficacy endpoint evaluated at months 3, 6, and 12 was the closure of fistulas (closure of all treated fistulas at baseline, confirmed by doctor’s clinical assessment and magnetic resonance imaging or transrectal ultrasonography). The patients additionally completed some scoring scales at each follow-up including simplified Crohn’s Disease Activity Index (CDAI), Perianal Disease Activity Index (PDAI), Inflammatory Bowel Disease Questionnaire (IBDQ), pain scores with visual analog score (VAS), and Wexner score. The data of inflammatory indexes were also collected.

Results

The healing rates of the observation group and the control group at months 3, 6, and 12 were as follows: 10/11(90.9%) vs 5/11(45.5%), 8/11(72.7%) vs 6/11(54.5%), and 7/11(63.6%) vs 6/11(54.5%), respectively. There was no statistical difference between the two groups. In addition, the improvement in simplified CDAI, PDAI, IBDQ, VAS, and Wexner score of the observation group were better than that of the control group at each follow-up. The inflammatory indexes decreased in both the observation group and the control group at 3 months follow-up. And there were no significant differences in the changes of inflammatory indexes between two groups at month 3 compared with the baseline. Safety was maintained throughout month 12, and adverse events occurred in 63.6% of patients in the observation group and 100% patients in the control group. And no adverse event associated with ADSC injection was observed in the study.

Conclusion

ADSC is a feasible and effective treatment for Crohn’s fistula-in-ano, compared with traditional incision and thread-drawing. It can protect anal function of patients, relieve pain, allow quick recovery, be well-tolerated, and improve the quality of life during perioperative period.

Trial registration

China Clinical Trials Registry, No. ChiCTR1800014599. Registered 23 January 2018.
Cognitive interventions for adults with chronic kidney disease: protocol for a scoping review
Authors: Farragher Janine F. , Stewart Katherine E. , Harrison Tyrone G. , Engel Lisa , Seaton Samantha E. , Hemmelgarn Brenda R.
Published: March 2020

Background

Cognitive impairment is a common and frequently under-recognized complication of chronic kidney disease (CKD). Although there is extensive literature on cognitive interventions that can ameliorate cognitive impairment or associated negative outcomes in the general literature, the breadth and characteristics of cognitive interventions that have been studied in people with CKD are currently unclear. The objective of this scoping review is to identify and describe the literature on cognitive interventions for adults with CKD, including end-stage kidney disease (ESKD).

Methods

A scoping review following Joanna Briggs Institute methodology will be conducted. With assistance from an information specialist, we will search 5 electronic databases (MEDLINE [OVID], EMBASE, PsycINFO, Cochrane Central Register of Controlled Trials, and CINAHL Plus) using search terms that represent the target population (CKD) and concept (cognition), and conduct backward citation searching for additional literature. Eligible sources will be primary research studies (quantitative or qualitative) that investigate any intervention targeting cognition in adults (≥ 18 years) with CKD or ESKD, including those treated with dialysis. We will extract data about characteristics of interventions (e.g., type, underlying theory, design, location, and provider), populations (e.g., stage of CKD, age, sex, and type of cognitive impairment), and studies (e.g., authors, location, design, and reported findings). Article screening and data extraction will be performed by two to three reviewers. Data will be analyzed using descriptive statistics and narrative syntheses to characterize the literature on cognitive interventions for people with CKD.

Discussion

This study will provide a comprehensive overview of the cognitive interventions that have been studied for people with CKD. It will help identify research gaps within this population (e.g., types of interventions that have yet to be investigated; best practices in cognition research that have not been implemented) and inform the direction of future research in this field.
Different screening frequencies of carbapenem-resistant Enterobacteriaceae in patients undergoing hematopoietic stem cell transplantation: which one is better?
Authors: Yang Ting-Ting , Luo Xue-Ping , Yang Qing , Chen Hong-Chao , Luo Yi , Zhao Yan-Min , Ye Yi-Shan , Lai Xiao-Yu , Yu Jian , Tan Ya-Min , Wei Guo-Qing , Huang He , Shi Ji-Min
Published: March 2020

Background

A consensus has been reached that carbapenem-resistantEnterobacteriaceae(CRE) screening in immunosuppressed individuals can reduce the incidence of CRE bloodstream infection (BSI).

Methods

We retrospectively studied the clinical data of 395 consecutive HSCT patients from September 2017 to April 2019. From September 2017 to June 2018 (period 1), 200 patients received single CRE screening before transplantation. From July 2018 to April 2019 (period 2), 195 patients received continuous weekly CRE screening after admission. For patients colonized with CRE, targeted managements were received: (1) contact precautions and (2) preemptive CRE-targeted treatment if necessary.

Results

During period 1, 3 patients with CRE colonization were detected (1.5%). The CRE BSI rate was 2.0% (4 patients), and the related 30-day mortality was 50.0% (2 out of 4 patients). During period 2, 21 patients with CRE colonization were detected, and the detection rate was significantly higher than that in period 1 (P < 0.001). Of the 21 colonized patients, 4 (19.0%) patients were identified as positive for CRE at the first screening, 5 (23.8%) were identified at the second screening, and the remaining 12 (57.1%) were identified at the third or later screening. The CRE BSI rate decreased to 0.5% (1/195), and there were no CRE-related death.

Fifteen colonized patients developed neutropenic fever. Thirteen colonizers were preemptively treated with tigecycline within 24 h of fever onset, and they achieved rapid temperature control. One colonizer received tigecycline later than 48 h after fever onset and ultimately survived due to the addition of polymyxin. The other received tigecycline later than 72 h after fever onset and died of septic shock.

Conclusion

The increase in screening frequency contributed to the detection of patients with CRE colonization. Targeted managements for these colonized patients may contribute to reducing the incidence and mortality of CRE BSI, therefore improving the prognosis of patients.
Clinical significance of precedent asymptomatic non-sustained ventricular tachycardias on subsequent ICD interventions and heart failure hospitalization in primary prevention ICD patients
Authors: Makimoto Hisaki , Zielke Sophie , Clasen Lukas , Lin Tina , Gerguri Shqipe , Müller Patrick , Schmidt Jan , Bejinariu Alexandru , Kurt Muhammed , Brinkmeyer Christoph , Stern Manuel , Kelm Malte , Fürnkranz Alexander
Published: March 2020

Background

The prognostic implications of non-sustained ventricular tachycardia (NSVT) and their significance as therapeutic targets in patients without prior sustained ventricular arrhythmias remain undetermined. The aim of this study was to investigate the prognostic significance of asymptomatic NSVT in patients who had primary prevention implantable cardioverter-defibrillator (ICD) implantation due to ischemic or non-ischemic cardiomyopathy (ICM, NICM).

Methods

We enrolled 157 consecutive primary prevention ICD patients without previous appropriate ICD therapy (AIT). Patients were allocated to two groups depending on the presence or absence of NSVT in a 6-month period prior to enrollment. The incidence of AIT and unplanned hospitalization due to decompensated heart failure (HF) were assessed during follow-up.

Results

In 51 patients (32%), precedent NSVT was documented. During a median follow-up of 1011 days, AIT occurred in 36 patients (23%) and unplanned HF hospitalization was observed in 32 patients (20%). In precedent NSVT patients, the incidence of AIT and unplanned HF hospitalization was significantly higher as compared to patients without precedent NSVT (AIT: 29/51 [57%] vs. 7/106 [7%], P < 0.001, log-rank; HF hospitalization: 16/51 [31%] vs. 16/106 [15%], P = 0.043, log-rank). Cox-regression demonstrated that precedent NSVT independently predicted AIT (P < 0.0001). In subgroup analyses, precedent NSVT predicted AIT in both ICM and NICM (P < 0.0001, P = 0.020), but predicted HF hospitalization only in patients with ICM (P = 0.0030).

Conclusions

Precedent non-sustained VT in patients with primary prevention ICDs is associated with subsequent appropriate ICD therapies, and is an independent predictor of unplanned heart failure hospitalizations in patients with ischemic cardiomyopathy.
Impact of resistance exercises and nano-curcumin on synovial levels of collagenase and nitric oxide in women with knee osteoarthritis
Authors: Cheragh-Birjandi Sadegh , Moghbeli Meysam , Haghighi Farideh , Safdari Mohammad Reza , Baghernezhad Maryam , Akhavan Arash , Ganji Reza
Published: March 2020

Background

Osteoarthritis is the most common joint damage that leads to cartilage destruction, pain, and disability. The aim of this study is to investigate the effects of resistance exercises and Nano curcumin supplementation on synovial levels of collagenase-2 and NO in patients with knee osteoarthritis.

Methods

Forty women with primary knee osteoarthritis were divided into four groups including control, exercise, supplementation, and supplementation /exercises. The resistance exercise group performed exercises in 16 weeks (three sessions per week). The supplement group consumed one Nano curcumin capsule (1000 mg) per day for 16 weeks. Exercise and supplementation group also performed resistance exercises along with consuming Nano curcumin. Synovial fluid samplings were done in two stages of pre-test (24 h before training and supplementation) and post-test (48 h after the last session of treatment and supplementation). The obtained synovial fluid was used to measure the synovial level of collagenase -II and nitric oxide.

Results

Although, there were not any significant correlations between resistance exercise, nanocurcumum supplementation, and synovial levels of collagenase-2 and NO among women with knee osteoarthritis, we observed interesting reduced levels of both markers following the supplementation.

Conclusions

It can be concluded that the Nano curcumin supplementation can be an effective method to reduce the levels of these inflammatory factors in synovial fluids of cases with knee Osteoarthritis. Longer duration of the protocol may have more promoting results.

Trial registration

The project was registered at Iranian Registry of Clinical Trials (Trial registration number: IRCT20161208031300N1).
Missing well log prediction using convolutional long short-term memory network
Authors: Pham Nam , Wu Xinming , Zabihi Naeini Ehsan
Published: March 2020

Reservoir characterization involves integration of different types of data to understand the subsurface rock properties. To incorporate multiple well log types into reservoir studies, estimating missing logs is an essential step. We have developed a method to estimate missing well logs by using a bidirectional convolutional long short-term memory (bidirectional ConvLSTM) cascaded with fully connected neural networks. We train the model on 177 wells from mature areas of the UK continental shelf (UKCS). We test the trained model on one blind well from UKCS, three wells from the Volve field in the Norwegian continental shelf, one well from the Penobscot field in the Scotian shelf offshore Canada, and one well from the Teapot Dome data set in Wyoming. The method takes into account the depth trend and the local shape of logs by using ConvLSTM architecture. The method is examined on sonic log prediction and can produce an accurate prediction of sonic logs from gamma-ray, density, and neutron porosity logs. The advantages of our method are that it is not applied on an interval by interval basis like rock-physics-based methods and it also outputs the uncertainties facilitated by dropout layers and Monte Carlo sampling at inference time.
A dynamic elastic model for squirt-flow effect and its application on fluid-viscosity-associated velocity dispersion in reservoir sandstones
Authors: Yang Zhi-Qiang , He Tao , Zou Chang-Chun
Published: March 2020

Velocity dispersion is a common phenomenon for fluid-charged porous rocks and carries important information on the pore structure and fluid in reservoir rocks. Previous ultrasonic experiments had measured more significant non-Biot velocity dispersion on saturated reservoir sandstones with increasing pore-fluid viscosity. Although wave-induced local squirt-flow effect could in theory cause most of the non-Biot velocity dispersion, its quantitative prediction remains a challenge. Several popular models were tested to predict the measured velocities under undrained conditions, but they either underestimated the squirt-flow effect or failed to simultaneously satisfy P- and S-wave velocity dispersions (especially for higher viscosity fluids). Based on the classic double-porosity theory that pore space is comprised of mainly stiff/Biot’s porosity and minor compliant porosity, an effective “wet frame” was hypothesized to account for the squirt-flow effect, whose compliant pores are filled with a hypothesized fluid with dynamic modulus. A new dynamic elastic model was then introduced by extending Biot theory to include the squirt-flow effect, after replacing the dry-frame bulk/shear moduli with their wet-frame counterparts. In addition to yielding better velocity predictions for P- and S-wave measurements of different fluid viscosities, the new model is also more applicable because its two key tuning parameters (i.e., the effective aspect ratio and porosity of compliant pores) at in situ reservoir pressure could be constrained with laboratory velocity measurements associated with pore-fluid viscosities.
Modeling the seismic response of individual hydraulic fracturing stages observed in a time-lapse distributed acoustic sensing vertical seismic profiling survey
Authors: Binder Gary , Titov Aleksei , Liu Youfang , Simmons James , Tura Ali , Byerley Grant , Monk David
Published: March 2020

In 2017, distributed acoustic sensing (DAS) technology was deployed in a horizontal well to conduct a vertical seismic profiling survey before and after each of 78 hydraulic fracturing stages. From two vibroseis source locations at the surface, time shifts of P- and S-waves were observed but decayed over days. Some stages also showed waves scattered off the stimulated rock volume. We have used 2D finite difference elastic wavefield modeling to understand these observations and connect them to underlying properties of the stimulated rock. We have developed an effective medium model of vertical fractures that close exponentially with time as fluid leaks off into the formation can match the distribution of P- and S-wave time shifts along the well. This has enabled estimates of the height, normal and tangential fracture compliance values, and decay time of the stimulated rock volume. Additionally, the kinematics of scattered waves observed in the data have been found to be consistent with PS conversion across the stimulated rock volume from an individual stage. With higher quality DAS data, stage-by-stage inversion for height, fracture compliance, and decay time attributes may be possible for characterizing variations in the effectiveness of hydraulic fracturing.
Phase I, Open-Label, Dose-Escalation/Dose-Expansion Study of Lifirafenib (BGB-283), an RAF Family Kinase Inhibitor, in Patients With Solid Tumors
Authors: Desai Jayesh , Gan Hui , Barrow Catherine , Jameson Michael , Atkinson Victoria , Haydon Andrew , Millward Michael , Begbie Stephen , Brown Michael , Markman Ben , Patterson William , Hill Andrew , Horvath Lisa , Nagrial Adnan , Richardson Gary , Jackson Christopher , Friedlander Michael , Parente Phillip , Tran Ben , Wang Lai , Chen Yunxin , Tang Zhiyu , Huang Wendy , Wu John , Zeng Dewan , Luo Lusong , Solomon Benjamin
Published: March 2020

PURPOSE

Lifirafenib is an investigational, reversible inhibitor of B-RAFV600E, wild-type A-RAF, B-RAF, C-RAF, and EGFR. This first-in-human, phase I, dose-escalation/dose-expansion study evaluated the safety, tolerability, and efficacy of lifirafenib in patients with B-RAF– or K-RAS/N-RAS–mutated solid tumors.

METHODS

During dose escalation, adult patients with histologically/cytologically confirmed advanced solid tumors received escalating doses of lifirafenib. Primary end points were safety/tolerability during dose escalation and objective response rate in preselected patients with B-RAF and K-RAS/N-RAS mutations during dose expansion.

RESULTS

The maximum tolerated dose was established as 40 mg/d; dose-limiting toxicities included reversible thrombocytopenia and nonhematologic toxicity. Across the entire study, the most common grade ≥ 3 treatment-emergent adverse events were hypertension (n = 23; 17.6%) and fatigue (n = 13; 9.9%). One patient with B-RAF–mutated melanoma achieved complete response, and 8 patients with B-RAF mutations had confirmed objective responses: B-RAFV600E/K melanoma (n = 5, including 1 patient treated with prior B-RAF/MEK inhibitor therapy), B-RAFV600E thyroid cancer/papillary thyroid cancer (PTC; n = 2), and B-RAFV600E low-grade serous ovarian cancer (LGSOC; n = 1). One patient with B-RAF–mutated non–small-cell lung cancer (NSCLC) had unconfirmed partial response (PR). Patients with K-RAS–mutated endometrial cancer and K-RAS codon 12–mutated NSCLC had confirmed PR (n = 1 each). No responses were seen in patients with K-RAS/N-RAS–mutated colorectal cancer (n = 20).

CONCLUSION

Lifirafenib is a novel inhibitor of key RAF family kinases and EGFR, with an acceptable risk-benefit profile and antitumor activity in patients with B-RAFV600–mutated solid tumors, including melanoma, PTC, and LGSOC, as well as K-RAS–mutated NSCLC and endometrial carcinoma. Future comparisons with first-generation B-RAF inhibitors and exploration of lifirafenib alone or as combination therapy in patients with selected RAS mutations who are resistant/refractory to first-generation B-RAF inhibitors are warranted.
Machine Learning Analysis of Individual Tumor Lesions in Four Metastatic Colorectal Cancer Clinical Studies: Linking Tumor Heterogeneity to Overall Survival
Authors: Vera-Yunca Diego , Girard Pascal , Parra-Guillen Zinnia P. , Munafo Alain , Trocóniz Iñaki F. , Terranova Nadia
Published: March 2020

Total tumor size (TS) metrics used in TS models in oncology do not consider tumor heterogeneity, which could help to better predict drug efficacy. We analyzed individual target lesions (iTLs) of patients with metastatic colorectal carcinoma (mCRC) to determine differences in TS dynamics by using the ClassIfication Clustering of Individual Lesions (CICIL) methodology. Results from subgroup analyses comparing genetic mutations and TS metrics were assessed and applied to survival analyses. Data from four mCRC clinical studies were analyzed (1781 patients, 6369 iTLs). CICIL was used to assess differences in lesion TS dynamics within a tissue (intra-class) or across different tissues (inter-class). First, lesions were automatically classified based on their location. Cross-correlation coefficients (CCs) determined if each pair of lesions followed similar or opposite dynamics. Finally, CCs were grouped by using the K-means clustering method. Heterogeneity in tumor dynamics was lower in the intra-class analysis than in the inter-class analysis for patients receiving cetuximab. More tumor heterogeneity was found in KRAS mutated patients compared to KRAS wild-type (KRASwt) patients and when using sum of longest diameters versus sum of products of diameters. Tumor heterogeneity quantified as the median patient’s CC was found to be a predictor of overall survival (OS) (HR = 1.44, 95% CI 1.08–1.92), especially in KRASwt patients. Intra- and inter-tumor tissue heterogeneities were assessed with CICIL. Derived metrics of heterogeneity were found to be a predictor of OS time. Considering differences between lesions’ TS dynamics could improve oncology models in favor of a better prediction of OS.
Can we rely on adolescents to self-assess puberty stage? A systematic review and meta-analysis
Authors: Campisi Susan C , Marchand Josée D , Siddiqui Fahad Javaid , Islam Muhammad , Bhutta Zulfiqar A , Palmert Mark R
Published: March 2020

Context

Clinicians, researchers, and global health advocates often include pubertal development in outcomes. However, assessments of pubertal stage can be challenging because of the sensitive nature and feasibility of clinical examinations, especially in larger settings.

Objective

To determine the accuracy of self-assessed Tanner staging when compared with physically assessed Tanner stages by a clinician.

Data Sources

MEDLINE, PubMed, Embase, Web of Science, Scopus, the Cochrane Library, CINAHL.

Study Selection

Studies were included if they reported 5 × 5 tables of self-assessment compared to clinician–assessment for the 5-stage Tanner scale.

Data Extraction

We extracted data to generate complete 5 × 5 tables for each study, including any subgroup eligible for the analysis, such as overweight/obese youth.

Data Synthesis

After screening, 22 studies representing 21,801 participants met our inclusion criteria for the meta-analysis. Overall agreement was moderate or substantial between the 2 assessments, with breast stage 1, female pubic hair 1, male pubic hair 1, and male pubic hair 5 having the highest agreement. When stages were collapsed into pre- (Tanner stage 1), in (stages 2,3), and completing (stages 4,5) puberty, levels of agreement improved, especially for pre- and completing pubertal development. Most included studies comprised Caucasian youth. More studies are needed which include a broader range of geographic and socioeconomic settings, as well as a greater diversity of racial/ethnic groups.

Conclusions

Self-assessment of puberty is most accurate when identifying Tanner stage 1, Tanner stage 5 and when development is categorized into prepuberty, in, and completing puberty phases. Use of self-assessment data should be structured accordingly.

Protocol Registration

PROSPERO # CRD42018100205
An interview with Eric Olson
Authors: Eve Alex
Published: March 2020

Eric Olson is Professor and Chair of Molecular Biology at the University of Texas Southwestern Medical Center, USA, where he holds the Robert A. Welch Distinguished Chair in Science, the Annie and Willie Nelson Professorship in Stem Cell Research and the Pogue Distinguished Chair in Research in Cardiac Birth Defects. In 1999, he was elected to the US National Academy of Sciences and, in 2001, to the Institute of Medicine of the National Academy. He has received several awards, including the American Heart Association Research Achievement Award in 2008 and the Eugene Braunwald Academic Mentorship award in 2016. He has a lifelong interest in muscle development and disease, with a particular interest in Duchenne muscular dystrophy. In this interview, conducted at the Society for Developmental Biology's 2019 meeting in Boston, Massachusetts, USA, he discusses his experiences in academia and industry, as well as reflecting on the people and opportunities that contributed to his career.
CLIC4 is a cytokinetic cleavage furrow protein that regulates cortical cytoskeleton stability during cell division
Authors: Peterman Eric , Valius Mindaugas , Prekeris Rytis
Published: March 2020

During mitotic cell division, the actomyosin cytoskeleton undergoes several dynamic changes that play key roles in progression through mitosis. Although the regulators of cytokinetic ring formation and contraction are well established, proteins that regulate cortical stability during anaphase and telophase have been understudied. Here, we describe a role for CLIC4 in regulating actin and actin regulators at the cortex and cytokinetic cleavage furrow during cytokinesis. We first describe CLIC4 as a new component of the cytokinetic cleavage furrow that is required for successful completion of mitotic cell division. We also demonstrate that CLIC4 regulates the remodeling of the sub-plasma-membrane actomyosin network within the furrow by recruiting MST4 kinase (also known as STK26) and regulating ezrin phosphorylation. This work identifies and characterizes new molecular players involved in regulating cortex stiffness and blebbing during the late stages of cytokinetic furrowing.
Repair and disposal of land transport-technological means
Authors: Mitrohin Nikolay , Pavlov Aleksey
Published: March 2020

In the textbook the definition and classification ground transport-technological means, the fundamentals of the organization of repair and considered in detail processes of repair, recovery and disposal of parts of land transport-technological means.
Meets the requirements of Federal state educational standards of higher education of the last generation.
For undergraduate students in areas of training "Exploitation of transport and technological machines and complexes" and "engineering", as well as to students of specialist degrees in the direction of training "Ground transport-technological means."
Physical education of children of preschool and younger school age
Authors: Gur'ev Sergey
Published: March 2020

Considered organizational and methodological questions on the physical education of children of preschool age and initial classes improving their motor skills on the basis of modern requirements. Described the forms and methods of organization of classes when teaching motor actions, regulation (metering) physical activity themselves training programs with detailed description of exercises. The proposed modern methods of physical education, monitor the physical condition of the children.
Meets the requirements of Federal state educational standards of secondary professional education of the last generation.
For teachers and specialists, whose activity is connected with physical education of children of preschool and younger school age and also for students of secondary professional and higher educational institutions enrolled in the enlarged group of specialties and areas of training "Education and pedagogical Sciences".
Topics business ideas
Authors: Krupina Nadezhda
Published: March 2020

In the textbook revealed effective analytical and communication potential of diverse methods of visualization: the nature, principles and rules of application, the techniques applied aspects in business planning and strategic management of a commercial organization.
Presents the theoretical and practical material will allow students of vocational education institutions to develop knowledge in a number of disciplines including "business Organization", "Organization and management of trade-marketing activities", "Management", "Economics", "Commerce", "Entrepreneurship".
Meets the requirements of Federal state educational standards of secondary professional education of the last generation.
For students and listeners of educational institutions of higher and secondary vocational education, post-graduate students of humanitarian, economic and managerial professions, and others interested in issues of business visualization.
The basics of technological preparation of production
Authors: Shalimov Mihail , Fiveyskiy Andrey , Votinova Ekaterina
Published: March 2020

The tutorial provides basic information about the purpose, content, basic principles and organization of technological preparation of welding production. The types of technical documents, their purpose and content; fundamentals of design of technological process of manufacture of welded structures. Special attention is paid to the optimisation of the design for manufacturability.
A careful study of the textbook material will prepare the student for designing welded structures with the required accuracy and reliability at a given performance and economic efficiency, as well as development of technological processes of welding, providing the weld joints with the desired properties of reliability and safe operation of welded products.
Designed for students training areas 15.03.01 mechanical engineering, 12.03.05 "Laser engineering and laser technologies" may be useful to students of lyceums, colleges, vocational schools and technical schools.
Formation at students of pedagogical profile "image of the parent" in the process of professional training at the University
Authors: Neretina Tat'yana , Orehova Tat'yana
Published: March 2020

In modern conditions of development of mankind, when, for various reasons endangered is the institution of the family, especially actual is a problem of formation of the growing person in the period of schooling parental position as an essential part not only of development but also the survival of humanity as a species. The solution to this problem in terms of the organization of Russian society goes along with the family on a school teacher. Hence the need to prepare future teachers for performing this task.
In the present monograph presents one approach to solving this problem through the formation of future teachers of "the way I parent," a deep awareness and understanding of the essence and structure of process of formation of own "image of the parent", the content of this phenomenon relevant content, development of representations about itself as about the parent, about other people and the world in General.
Intended for University students, primary school teachers, specialists in educational work, as well as for lecturers reading a course of lectures on subjects connected with pedagogy, psychology and ethic of family education.
Personnel management in Russia: vector of humanization. Book 7
Authors: Razumova Tat'yana , Spiridonova Natal'ya , Durakova Irina , Taltynov Sergey , Mayer Ekaterina , Sotnikova Svetlana , Zhukov Anatoliy , Dolzhenkova Yuliya , Rudenko Galina , Shiryaev Oleg , Mitrofanova Aleksandra , Konovalova Valeriya , Gorskaya Lidiya
Published: March 2020

The monograph contains the results of studies concerning: first, the evolution of ideas and practice of humanization in the personnel policy of the state; second, the implementation of the principles of humanization in work with the personnel of economic subjects: talent management, renewal of working capacity of older workers, building a dual career, building a strong corporate culture, the development of the additional professional education system; thirdly, problems related to industry characteristics personnel work, drawing on international experience of vocational rehabilitation and employment promotion of persons with disabilities, concerning the roles of personal characteristics and character pathology in the context of modern life; fourth, approaches to the weakening of the precarization of labor, University teachers, gender discrimination in the labour market, working with a "toxic" staff, to prevent stress in the workplace.
Addressed to scientific-pedagogical and practical workers in the sphere of work with personnel; graduate students, undergraduates, students, professional interests which relate to issues of personnel management.
Philosophical-anthropological project of Russian organicism and cosmism Russian in the context of the contemporary historical situation
Authors: Masloboeva Ol'ga
Published: March 2020

This monograph explains the historical necessity of the emergence in the nineteenth century the Russian organicism, and the subsequent birth of his Russian cosmism. On the basis of the age of the principle of the analysis of the history, the idea of which originated in Antiquity, but the most consistent development was in the works, T. N. Granovsky, reveals the connection of the inner logic of a growing world and domestic philosophical thought. Suitable vzaimodeystvie development of the West-European and Russian philosophy is confirmed by the comparative analysis of the evolution of philosophical anthropology, presented in the second section of the monograph.
For students and teachers and all those interested in issues of Russian organicism and cosmism Russian.
The mathematical analysis. Volume 2
Authors: Zhukova Galina , Rushaylo Margarita
Published: March 2020

The aim of the tutorial is to help students to master the basic concepts and methods of the study of calculus. In volume 2 we study analytic geometry in space; differential calculus of functions of several variables; local, conditional, global extrema of functions of several variables; multiple, curvilinear and surface integrals; elements of field theory; numerical, power series, Taylor series and Maclaurin, and Fourier series; applications to the analysis and solution of applied problems. Great attention is paid to comparison of these methods, the proper choice of study design tasks, analyze complex situations that arise in the study of these branches of mathematical analysis.
For self-training and quality control knowledge given test questions.
For teachers, students and postgraduate students studying mathematical analysis.
The impact of swine influenza and how to control it on farm
Authors: Gale Christina , Velazquez Eduardo , Pattison Emma
Published: March 2020

Swine influenza (SIV) can reduce productivity on farm and therefore can have a large economic impact also. The virus has four common lineages in swine, H1avN1av, H1huN2, H3N2 and H1pdmN1pdm (the pandemic strain). The virus invades the respiratory tract and therefore the majority of clinical signs are of respiratory nature, including sneezing, coughing and nasal discharge, which can also be accompanied by fever and lethargy. Diagnosis of the disease is important to determine the strain on the farm and therefore implement a control plan which may include biosecurity and hygiene measures in combination with vaccination. Vaccination has been shown to be effective in reducing the clinical signs, lung lesions and the viral shedding. Vaccination of the breeding herd can result in an improvement in reproductive performance, such as a reduction in the return to oestrus rate and an increase in the number of piglets born alive. Control of SIV should be a combined approach to achieve the best results on farm.
Bovine respiratory disease — challenges and opportunities
Authors: Potter Tim
Published: March 2020

Bovine respiratory disease (BRD) remains a significant issue to farming around the world. Technology is now available that can be used to improve the speed and accuracy of detection, and it is important that we consider how this technology can best be implemented to maximise its returns. The use of antimicrobials in farming remains high on the agenda and this article discusses some of the key things to consider when prescribing for BRD to maximise effect and reduce the potential for the emergence of resistance. To truly control BRD it is essential that we consider the farm and potentially the industry holistically. At a farm level it is essential that all potential risk factors are managed to reduce disease. Further opportunities for reducing the risk of disease are offered by closer working relationships between farms and integrated supply chains as these can reduce the stress around periods of transition and also enable better control of endemic diseases
Hybrid ultrathin-silicon/graphene waveguide photodetector with a loop mirror reflector
Authors: Li Jiang , Yin Yanlong , Guo Jingshu , Liu Chaoyue , Dai Daoxin
Published: March 2020

Graphene has emerged as a promising solution for on-chip ultrafast photodetection for its advantages of easy integration, high mobility, adjustable chemical potential, and wide operation wavelength range. In order to realize high-performance photodetectors, it is very important to achieve efficient light absorption in the active region. In this work, a compact and high-speed hybrid silicon/graphene photodetector is proposed and demonstrated by utilizing an ultra-thin silicon photonic waveguide integrated with a loop mirror. With this design, the graphene absorption rate for the fundamental mode of TE polarization is improved by ∼5 times compared to that in the conventional hybrid silicon/graphene waveguide with hco=220 nm. One can achieve 80% light absorption ratio within the active-region length of only 20 µm for the present silicon/graphene waveguide photodetector at 1550 nm. For the fabricated device, the responsivity is about 25 mA/W under 0.3V bias voltage and the 3-dB bandwidth is about 17 GHz. It is expected to achieve very high bandwidth by introducing high-quality Al2O3 insulator layers and reducing the graphene channel length in the future.
Automatic calibration of silicon ring-based optical switch powered by machine learning
Authors: Gao Wei , Lu Liangjun , Zhou Linjie , Chen Jianping
Published: March 2020

Calibrating ring-based optical switches automatically is strongly demanded in large-scale ring-based optical switch fabrics. Supported by a machine-learning algorithm, we build an artificial neural network (ANN) model to retrieve the parameters of a 2×2 dual-ring assisted Mach-Zehnder interferometer (DR-MZI) switch from the measured spectra for the first time. The calibration algorithm is verified on several devices. The operating wavelength of the optical switch can be tuned to any wavelength in a free spectral range with an accuracy better than 90 pm. The extinction ratio exceeds 20 dB at the cross- and bar-states with no more than 7 calibration cycles. The voltage difference between the automatic calibration and manual tuning is less than 30 mV, showing the high accuracy of the calibration algorithm. Our scheme provides a new way to calibrate ring-based devices that work as optical switch fabrics and tunable optical filters.
Fast method for calculating a curved hologram in a holographic display
Authors: Kang Ruidan , Liu Juan , Pi Dapu , Duan Xinhui
Published: March 2020

A curved hologram can increase the view angle in a holographic display. The huge data processing and curved computer-generated hologram (CCGH) computation time is still a challenge for real-time display. Here, we propose two fast methods to accelerate the computation. The first one is a diffraction compensation (DC) method where the diffraction calculation is from the wave-front recording plane (WRP) to a CCGH. The other is an approximate compensation (AC) method that adds a phase difference distribution to the WRP to obtain the CCGH. Numerical simulations and optical experiments are performed, which demonstrate that the two methods are feasible and the computation time is dramatically reduced. The AC method can further reduce time significantly compared with the DC method. And the image quality for proposed methods is similar. It is expected that these fast methods can be combined with curved display screen and flexible display materials in the future.
Coupled-mode induced transparency via Ohmic heating in a single polydimethylsiloxane-coated microbubble resonator
Authors: Liu Xianlin , Lu Qijing , Fu Liang , Chen Xiaogang , Wu Xiang , Xie Shusen
Published: March 2020

We demonstrate an approach for the realization of coupled-mode induced transparency (CMIT) in a hybrid polydimethylsiloxane (PDMS)-coated silica microbubble resonator, with an Au microwire inserted in the hollow channel. Owing to the large negative thermo-optics coefficient of PDMS, different radial order modes with opposite thermal sensitivities can coexist in this hybrid microcavity. By applying a current through the Au microwire, which acts as a microheater, the generated Ohmic heating could thermally tune the resonance frequencies and the frequency detuning of the coupled mode to achieve controllable CMIT. This platform offers an efficient and convenient way to obtain controllable CMIT for applications, such as label-free biosensing and quantum information processing.
Observation of a comb of squeezed states with a strong squeezing factor by a bichromatic local oscillator
Authors: Shi Shaoping , Wang Yajun , Tian Long , Wang Jinrong , Sun Xiaocong , Zheng Yaohui
Published: March 2020

We demonstrate the experimental detection of an optical squeezing covering several higher resonances of the optical parametric amplifier (OPA) by adopting a bichromatic local oscillator (BLO). The BLO is generated from a waveguide electro-optic phase modulator (WGM) and subsequent optical mode cleaner (OMC), without the need of additional power balance and phase control. The WGM is used for generating the frequency-shifted sideband beams with equal power and certain phase difference, and the OMC is used for filtering the unwanted optical modes. Among a measurement frequency range from 0 to 16.64 GHz, the maximum squeezing factors are superior to 10 dB below the shot noise limit for the first three discrete odd-order resonances of the OPA.
Multimode-fiber-based single-shot full-field measurement of optical pulses
Authors: Xiong Wen , Gertler Shai , Yilmaz Hasan , Cao Hui
Published: March 2020

Multimode fibers are explored widely for optical communication, spectroscopy, imaging, and sensing applications. Here we demonstrate a single-shot full-field temporal measurement technique based on a multimode fiber. The complex spatiotemporal speckle field is created by a reference pulse propagating through the fiber, and it interferes with a signal pulse. From the time-integrated interference pattern, both the amplitude and the phase of the signal are retrieved. The simplicity and high sensitivity of our scheme illustrate the potential of multimode fibers as versatile and multi-functional sensors.
Finding our way: The experiences of a rapper and his advisor in a bachelor of music programme
Authors: Martignetti Frank , Brewster Joshua M.
Published: March 2020

Aspiring popular musicians, particularly rappers, often feel unwelcome in tertiary music study. While hip hop has entered the academy through other fields, it is still mostly absent from music departments. In 2014, a rapper began studies in a small, open Bachelor of Music programme that had no coursework or specialists in this area. His course of study ultimately looked somewhat similar to other students’ but also included a blend of coursework in music technology, poetry, literature, communications and business. This action research study examines the student’s experience and perspectives as he prepared to graduate in May 2018, as well as the researcher’s experience and perspectives as his advisor and teacher. It is hoped that this study will enable institutions to better serve future such students.
La «Dogmática Ignaciana» desde la «vida cristiana ignaciana»
Authors: Zas Friz Rossano
Published: March 2020

El presente artículo comenta el volumen Dogmática Ignaciana, publicado con la colaboración de 13 especialistas, y lo hace desde la perspectiva de la relación entre experiencia y reflexión, tal y como se está desarrollando en una reciente área de investigación de la tradición ignaciana. Una vez presentada la relación entre experiencia ignaciana y teología dogmática ignaciana, tal como se sostiene en el libro, se interpreta la misma relación desde otra perspectiva y, sobre esta base, se comentan las 17 contribuciones del libro. De este modo, en ocasión de la nueva publicación, y gracias a ella, se propone un nuevo paradigma que trasforma la así llamada espiritualidad ignaciana, propia de una concepción de cristiandad, en vida cristiana ignaciana, más adecuada para la actual etapa postcristiana, pues replantea el tradicional enfoque de la relación entre experiencia cristiana y reflexión teológica desde el proceso de toma de decisiones.
Evaluating ERP System Merging Success In Chemical Companies: System Quality, Information Quality, And Service Quality
Authors: Gaol Ford Lumban , Puryasana Intan , Matsuo Tokuro
Published: March 2020

This study is aimed to analyze success of the Enterprise Resource Planning (ERP) System Merging in Chemical Company Singapore that acquired two companies. The success component of ERP system success is using DeLone and McLean success model with qualitative method. The research methodology used detail interview with project implementation team, ERP consultants (8 informants) to get more detail from ERP system merging with information and collected supporting data from the ERP system itself. The result shows that ERP System Merging succeed to increase the system quality of Chemical Company which acquired two companies into one ERP system. It was depicted by the increment of easiness on using the system. The information much more integrated and accurate after the ERP system merging. Meanwhile service quality was increased because of all incidents now monitored in one efficient log system and handled by experienced IT application support team.
Enhancement of cured cement using environmental waste: particleboards incorporating nano slag
Authors: Ali Isam Mohamad , Nasr Mohammed Salah , Naje Ahmed Samir
Published: March 2020

Industrial waste is constantly increasing, so measures must be taken to recycle it in more practical and environmentally friendly ways. The aim of this study was to investigate the suitability of sawdust wasted particles for the production of cement bonded particleboards, and to enhance their compatibility with cement by using physical pretreatment processes, addition of nano slag and accelerated carbonation curing. All tests were carried out with different manufacturing parameters: sawdust/cement: (20%, 30% and 40%), treated and untreated wood, CO2curing and the addition of nano slag. Experiments were performed to assess the mechanical properties of produced particleboards such as density (D), water absorption (WA), thickness swelling (TS), bending strength (BS), and microstructural properties of the cement particleboards. For treated sawdust, the outcomes demonstrated an enhancement in the mechanical and microstructural characteristics of produced cement bonded particleboards by using the accelerated CO2curing method for sawdust particleboards. According to Scanning Electron Microscopy (SEM) micrographs, part of the carbonate crystals was found to be diffused into the cell walls and cavities and were found to protrude from sawdust surfaces.