bluuebunny/crossref_metadata_2025 huggingface dataset:
Životinje, šutljivi svjedoci Božje tajne u misli svetoga Ambrozija
Authors: Tukara Drago
Published: September 2022

Članak polazi od činjenice da svaka civilizacija i kultura svjedoče o smislu i vrijednosti životinja u svagdanjem čovjekovu životu i u osmišljavanju njegove egzistencije. Autor uzima u obzir samo nekoliko životinja, njih osam, neke u parovima, a neke pojedinačno, i to samo one koje hodaju po zemlji. Svaka od njih stoji u naslovu rada s istaknutim karakteristikama i čini po jedno poglavlje. Životinje koje su uzete u razmatranje uzete su na temelju opusa sv. Ambrozija. Inače, crkveni oci poslužili su se životinjama i njihovim oznakama za naviještanje i otkrivanje Božjega mističnoga plana preko stvorenja. Simbolika životinja upućuje na usku povezanost zemaljske i nadnaravne stvarnosti, prije svega s kristološkim simbolizmom.
Odgojiteljice, vjeroučitelji i vjeroučiteljice pred izazovima pandemije i potresa
Authors: Jurić Kata s. Amabilis
Published: September 2022

Na temelju teološko-katehetske, religiozno-pedagoške i sociološke literature u radu su predstavljeni rezultati kvalitativnoga istraživanja o promišljanjima odgojiteljica, vjeroučitelja/ica i ravnatelja Zagrebačke i Sisačko-moslavačke županije u kojoj mjeri kršćanska vjera pomaže pronaći smisao u vremenu krize pandemije i potresa te pruža li čvrstu nadu kao oslonac u različitim okolnostima radi poboljšanja kvalitete života u predškolskim ustanovama, Centrima za odgoj i obrazovanje, osnovnim i srednjim školama. U prvom dijelu ovoga znanstvenoga rada ukratko je objašnjena metodologija kvalitativnih istraživanja koja pruža mogućnost detaljnijega i dubljega sagledavanja i razumijevanje problema koji se istražuje. Iskazi sugovornika u dubinskom intervjuu o promišljanjima pred izazovima pandemije i potresa, opisani u drugom dijelu rada, omogućuju dublje razumijevanje percepcije aktualnoga stanja u odgojno-obrazovnim ustanovama s posebnim naglaskom na duhovno-vjerničkim proživljavanjima vremena u kojem živimo. Dobiveni rezultati pokazuju da se intervjuirani vjeroučitelji, unatoč općeljudskim osjećajima straha, anksioznosti, nesigurnosti, tjeskobe i izgubljenosti, uspijevaju hrabro i odvažno nositi kroz ovo vrijeme zahvaljujući čvrstom pouzdanju u Boga, molitvi, vjeri i nadi, što je evidentno u njihovu još zauzetijem i predanijem radu s djecom i mladima.
Giudizio e annuncio di un incontro nuovo: analisi del messaggio di Mt 23,37-39 (I)
Authors: Čatić Ivica
Published: September 2022

Il lavoro, diviso nei due articoli successivi, intende indagare il messaggio di breve pericope Mt 23,37-39. L’importanza della ricerca proviene da alcuni fatti il quale primo è rapporto drammatico tra Israele ed il suo Messia, come lo presenta il Primo evangelista, e dal fatto che Mt 23,37-39 contiene l’ultime parole di Gesù rivolte al popolo d’Israele prima del racconto della passione. Il secondo fatto si riferisce all’unanimità degli studiosi riguardo al messaggio del testo. Esso presenta un crux interpretorum al quale sono state assegnate contrastanti interpretazioni. Una prima linea degli interpretatori comprende la nostra pericope come l’annuncio della salvezza finale; l’altra, invece, pensa che si tratta di un giudizio definitivo mentre la terza qui trova il messaggio di salvezza condizionata. In situazione di tale disaccordo tra i ricercatori autorevoli spinge ad intraprendere l’analisi esaustiva del testo di Mt 23,37-39 la quale mette sotto analisi ogni punto pertinente al messaggio finale. Il risultato di questa ricerca per primo offrirà la base di proporre la nostra interpretazione propria e, per secondo, presenterà il contributo per facilitare comprensione dell’impatto del nostro testo sull’insieme della teologia del Vangelo di Matteo. L’importanza di questo tema viene accentuata anche nel contesto del dialogo interreligioso recente perché potrebbe facilitare un passo avanti verso la verità che, benché questo oggi non è ancora evidente, è unica per tutti. Questo primo articolo contiene l’analisi letteraria della nostra pericope. Essa appartiene principalmente alla lettura sotto l’aspetto sincronico, benché non è escluso l’uso temporaneo di elementi del metodo storico-critico e dell’analisi in chiave comunicativa. Nel lavoro saranno esaminati contesto remoto e prossimo, delimitazione ed articolazione del testo, mentre il secondo articolo prosegue con analisi semantica.
Mesijanska obećanja i ispunjenje prema dokumentu Biblija i kristologija te kristologiji
C. Schönborna
Authors: Gašpar Veronika s. Nela , Batur Marin
Published: September 2022

Papinska biblijska komisija objavila je dokument Biblija i kristologija kao kriterij i normu suvremenoj kristologiji. Njegova važnost leži ponajprije u inzistiranju na cjelovitosti biblijske slike Krista, a kao temeljnu biblijsku strukturu ističe odnos obećanje – ispunjenje. Pitanje o Kristu, Mesiji, i zahtjevu cjelovite biblijske slike Krista prema dokumentu Biblija i kristologija te kristologije C. Schönborna u središtu je ovoga članka. Dok je prvo poglavlje posvećeno mesijanskim obećanjima u Starom zavjetu, drugo poglavlje govori o njihovu ispunjenju u Isusu iz Nazareta. Treće poglavlje ovoga rada usredotočeno je na kristologiju C. Schönborna i njezino poštovanje cjelovitosti biblijskoga svjedočanstva o Kristu. U zaključku rada autor upozorava na to da suvremene biblijske znanosti ističu potrebu novoga propitivanja o odnosu obećanja prisutnih u Starom zavjetu i gledanju Novoga zavjeta na ta obećanja i njihovo ispunjenje. To znači da i pred kristologijom stoji novi zahtjev promišljanja odnosa Biblije i kristologije.
mirna-27a Targets Sprouty Homolog 2 Expression to Affect Growth of Blood Vessels into Degenerated Intervertebral Disc
Authors: Wang Ping
Published: September 2022

This study aimed to evaluate the effects of miRNA-27a-targeting sprouty homolog 2 (SPRY2) on nucleus pulposus cell (NPC)-induced angiogenesis of human microvascular endothelial cells (HMEC-1) in degenerated intervertebral disc. Intervertebral disc tissues were collected from patients with scoliosis (control) and intervertebral disc degeneration (IDD). HMEC-1 cells were divided into control, negative control, sh-miR-27a, miR-27a, SPRY2 and miR-27a + SPRY2 groups. The invasive and angiogenic abilities of HMEC-1 cells were detected through Transwell and tube formation assays. TGF-â1 levels in NPCs and mixed medium were detected by enzyme-linked immunosorbent assay. MiR-27a expression in the intervertebral disc tissue of IDD group significantly exceeded that of the control group. In the SPRY2 group, the number of invading HMEC-1 cells decreased (P<0.05). Compared with the miR-27a group, the miR-27a + SPRY2 group had weakened invasive and angiogenic abilities, and decreased TGF-â1 expression (P<0.05). MiR-27a promotes NPC-induced angiogenesis of HMEC-1 cells through targeted inhibition of SPRY2 expression.
Effects of EGFR Mutations on NSCLC Patients Treated by Ramucirumab plus Docetaxel
Authors: Gong Huanxiu
Published: September 2022

The present paper attempted to define the effects of epidermal growth factor receptor (EGFR) mutations on patients with non-small cell lung cancer (NSCLC) treated by ramucirumab plus docetaxel. Of the 82 enrolled patients, 48 underwent EGFR mutations, showing relevance to sex and smoking history (P<0.05). The analysis yielded that EGFR-mutant (EGFR-Mut) group had a higher objective response rate versus EGFR-wild-type (EGFR-Wt) group (P<0.05). Subsequent to treatment, serum VEGF, bFGF, HDGF, CEA, CA153, CYFRA21-1 and CA199 levels dropped more significantly in EGFR-Mut group (P<0.05). Beyond that, EGFR-Mut exhibited a lower ZPS score and a higher KPS score versus EGFR-Wt group (P<0.05). Further, EGFR-Mut patients displayed strikingly longer median survival time versus EGFR-Wt patients (P<0.05). Ramucirumab plus docetaxel can safely inhibit tumour angiogenesis and regulate the levels of serum tumour markers. EGFR-Mut NSCLC patients with brain metastasis have better treatment outcomes and longer survival.
A novel approach to energy-aware resource management: Toward green NOMA heterogeneous networks
Authors: Nabipour Mohammad , Momen Amir Reza
Published: September 2022

The dense deployment of small cell networks is a key feature of next generation mobile networks aimed at providing the necessary capacity increase. In order to reach an acceptable performance in such ultra-dense networks, real-time resource management is of great importance. Therefore, self-optimization networking is proposed as the only viable solution to increase the networks’ utility. This paper proposed a self-optimizing model to enhance network performance and guarantee the users’ QoS requirements by considering limited resources and using effective user association, carrier scheduling and handover optimization algorithms. In order to maximize the network performance, we applied the smart backhauling technique in order to analyze the signaling to increase the validity of the decision making process. Based on the semantic information extracted from the access layer, the network decision-making center is able to adjust the network parameters and resource allocation effectively. The goal function is defined as maximizing the total energy efficiency by considering the transmission power, energy harvesting capability and the user QoS constraints so that the idle small cells are considered turned off temporarily to boost the power efficiency. Although the optimization problem is non-convex, a quadratic mixed-integer function is solved to obtain a global optimal solution. Since the actual implementation of the real-time algorithm has high computational complexity, two algorithms with different complexity levels are proposed. These algorithms use the carrier matching feature and optimal transmission power for problem-solving. The simulation results prove that, despite the increased computational complexity, effective resource allocation and optimal HO relations made the proposed approach capable to increase performance indices such as network throughput by up to 30%.
Hyperorality in Frontotemporal Dementia: Cognitive and Psychiatric Symptom Profiles in Early-Stage Disease
Authors: Morrow Christopher B. , Chaney Grace-Anna S. , Capuzzi Daniel , Bakker Arnold , Onyike Chiadi U. , Kamath Vidyulata
Published: September 2022

Hyperorality is a distinctive feature of the behavioral variant of frontotemporal dementia (bvFTD), but little is known about its significance in early-stage disease. This study examined the cognitive and psychiatric symptom profiles associated with hyperorality, using data from subjects with early-stage bvFTD enrolled in Alzheimer’s Disease Research Centers. We found that hyperorality was not associated with cognitive performance, but was associated with psychosis, elation, and disinhibition. Hyperorality may share neurobiology with a subset of early psychiatric symptoms, a finding which could help identify targets for future treatment.
Fatty Acid-Binding Protein 3 Is a Marker of Neurodegeneration and White Matter Hyperintensity Burden in Mexican American Older Adults
Authors: Clark Alexandra L. ,   for the Health and Aging Brain Study – Health Disparities (HABS-HD) Study Team, Haley Andreana P. , Duarte Audrey , O’Bryant Sid
Published: September 2022

We examined ethnoracial differences in fatty acid binding protein (FABP)—a family of intracellular lipid carriers—and clarified FABP3 associations with gray and white matter. Relative to Mexican Americans (MAs), FABP3 was higher in Non-Hispanic Whites (NHWS, p < 0.001). Regressions revealed, independent of traditional AD markers, FABP3 was associated with neurodegeneration (B = –0.08, p = 0.003) and WMH burden (B = 0.18, p = 0.03) in MAs, but not in NHWs (ps > 0.18). Findings suggest FABP3 is related to neural health within MAs and highlight its potential as a prognostic marker of brain health in ethnoracially diverse older adults.
Classification of data on stacked autoencoder using modified sigmoid activation function
Authors: Kumar Arvind , Singh Sodhi Sartaj
Published: September 2022

A Neural Network is one of the techniques by which we classify data. In this paper, we have proposed an effectively stacked autoencoder with the help of a modified sigmoid activation function. We have made a two-layer stacked autoencoder with a modified sigmoid activation function. We have compared our autoencoder to the existing autoencoder technique. In the existing autoencoder technique, we generally use the logsigmoid activation function. But in multiple cases using this technique, we cannot achieve better results. In that case, we may use our technique for achieving better results. Our proposed autoencoder may achieve better results compared to this existing autoencoder technique. The reason behind this is that our modified sigmoid activation function gives more variations for different input values. We have tested our proposed autoencoder on the iris, glass, wine, ovarian, and digit image datasets for comparison propose. The existing autoencoder technique has achieved 96% accuracy on the iris, 91% accuracy on wine, 95.4% accuracy on ovarian, 96.3% accuracy on glass, and 98.7% accuracy on digit (image) dataset. Our proposed autoencoder has achieved 100% accuracy on the iris, wine, ovarian, and glass, and 99.4% accuracy on digit (image) datasets. For more verification of the effeteness of our proposed autoencoder, we have taken three more datasets. They are abalone, thyroid, and chemical datasets. Our proposed autoencoder has achieved 100% accuracy on the abalone and chemical, and 96% accuracy on thyroid datasets.
EEG-based drowsiness analysis using OpenBCI and deep learning approaches to establish driving safety
Authors: Priyanka S. , Shanthi S.
Published: September 2022

Drowsiness is the inactivated state of the brain and observed during the transition from awaken state to sleepy state. This inactive state diminishes an individual’s attention and leads to accidents during professional or personal activities. The prediction of this inactive (drowsiness) state using AI plays a substantial role in the avoidance of accidents. The advancements in the field of Artificial Intelligence and Neuroscience approaches are used for the prediction of this inactive drowsy state. In order to prevent these devastating accidents, the state of drowsiness of the driver has to be be monitored. Electroencephalogram (EEG) is a predominant tool adopted to examine various states of the brain effectually. It is generally known as Brain-Computer Interface System. The EEG channels are used for predicting the inactive state while implementing the real-time applications. However, the researchers face various challenges during execution based on the classification and channel selection process. This research concentrates on modelling and efficient drowsiness prediction methods and intends to bridge the gap encountered in the existing approaches. A novel stacked Long Short-Term Memory(s - LSTM) with Deep Fully Connected- Convolutional Neural Network (DFC - CNN) is used to learn and memorize the long-term feature dependencies and attains essential information based on time-series prediction. Single and multi-channel EEG data is considered to measure the statistical characteristics of available EEG signals. The online available OpenBCI sleep analysis data is used for performing the experimentation, and run in GoogleColab environment. The proposed s - LSTM model provides a better trade-off compared to existing approaches. The model generalization is improved with the validation of combined feature subjects. Here, metrics like prediction accuracy, RMSE, false positives, scaling coefficients related to false positives are measured to show the significance of the model.
Safemedchain — drug counterfeit prevention and recommendation using blockchain and machine learning
Authors: Gopikarani N. , Gayathri B. , Praja S.S. , Sridharan Sneha
Published: September 2022

Counterfeit drugs are without a doubt becoming a greater hazard to consumers and the pharmaceutical sector. As a result, real-time visibility of drug manufacturing and management is required. The proposed system uses Ethereum blockchain as the main technology. The primary advantage of blockchain technology is that the transactions are maintained in immutable digital ledger format and it may be read easily without jeopardizing the users’ security and privacy. In our proposed system, the admin validates and adds the manufacturers. The manufacturer after registering and logging in can perform tasks like adding the drug and seller list. The seller can place order to the manufacturer which the manufacturer can accept or reject. The seller can update status of order of accepted orders to delivered. The customer can view the order details by entering the serial number on the drug package. Any transaction or exchange that occurs in the network is recorded in the chain. It functions similarly to other networks, but blockchain technology is distinguished by the fact that no data can be removed or altered by anyone in the network. No changes to the network can be made unless it has been validated by all of the network’s authorized users. All the information stored can be read by anybody so to incorporate more security, AES has been used to store data in the blockchain. The use of AES encryption technique distinguishes this system from all the existing implementations. Thus, this makes it easy to trace to the exact point in the supply chain and detect any counterfeit drugs in movement. As an extension to the drug counterfeit prevention system a Drug Recommendation System is also performed using the ensemble model with a combination of Random Forest and Logistic Regression for sentiment analysis training. Furthermore, when compared to the existing Linear SVM model, which has an accuracy of 90.39%, the suggested model has the best accuracy of 93.31%. Using the obtained sentiment for each drug, the drug is predicted accurately for the specified medical condition.
An augmented semantic search tool for multilingual news analytics
Authors: Harikumar Sandhya , Sathyajit Rohit , Karumudi Gnana Venkata Naga Sai Kalyan
Published: September 2022

News feeds generate colossal amount of data consisting of important information hidden in the intricacies. State of the art methods are still at infancy in providing a very generic and publicly available solution to skim through the important information in the news from various sources and an ability to search using specific keywords in different languages. This paper focuses on designing a tool to extract semantic details from news articles published through various internet sources in various languages. The semantic information is stored within DBMS for ease of organizing and retrieving the data. Further, a querying facility to search through entire articles based on the keyword or date-based search is also proposed to view the crisp content. The news articles in English, and two Indian languages - Hindi and Malayalam are considered for experimentation. The proposed strategy consists of two main components namely, Generative model creation and Query engine. Generative model aims to extract important entities and keywords along with their relevance to the article and other similar articles using Latent Dirichlet Allocation(LDA) and Named Entity Recognition(NER). Query engine is to facilitate on the fly retrieval of semantic content from the database, based on user keyword. The search engine, along with database indexing, reduces the access time to the database thereby retrieving the information in less time. Experimental results show that the proposed method is effective in terms of quality of information and time consumed for information retrieval.
Fabrication and RF test of the 500 MHz-RFQ linear accelerator for a transportable neutron source RANS-III
Authors: Ikeda Shota , Kobayashi Tomohiro , Otake Yoshie , Matsui Ryuji , Okamura Masahiro , Hayashizaki Noriyosu
Published: September 2022

At RIKEN, a transportable accelerator-driven compact neutron source (RANS-III) is under development for an on-site nondestructive inspection of the degradation of old concrete and reinforcing steel. RANS-III consists of an ion source, a low-energy beam transport, a radio frequency quadrupole linear accelerator (RFQ linac), a radio frequency (RF) system, a high-energy beam transport, a target station and a neutron measurement system. Because the inner diameter of the RFQ linac is inversely proportional to the resonance frequency, the resonance frequency of the RANS-III RFQ linac in this study was chosen to be 500 MHz, which is 2.5 times that of the RANS-II RFQ linac. Therefore, the inner diameter and weight of the RANS-III RFQ linac were reduced to approximately half and one third, respectively, of those of the RANS-II RFQ linac. The RANS-III RFQ linac was designed to accelerate a proton beam with a 10 mA peak current and 100 μA average beam current from 30 keV to 2.49 MeV (Journal of Disaster Research 12(3) (2017) 585–592). Based on the evaluations, an RFQ linac for RANS-III was fabricated, and the RF characteristics of the cavity, such as the resonant frequency and electric-field distribution, were measured using a low-power test and tuned using fixed tuners. In addition, RF couplers and RF systems were constructed to inject RF power into the RANS-III RFQ linac, and RF input tests were performed.
Intraoperative lung-protective ventilation adjusting tidal volume to a plateau pressure restriction in elderly patients: A randomized controlled clinical trial
Authors: Zhou Xinyi , Dong Chunshan , Zhang Jun , Sun Peng , Lu Qiang , Ma Xiang
Published: September 2022

BACKGROUND: Lung-protective ventilation (LPV) strategies have been considered as best practice in the care of critically patients. OBJECTIVE: This study aimed to investigate the effects individualized perioperative LPV with a positive end-expiratory pressure (PEEP) and low tidal volumes (VT) based on a target airway plateau pressure (Pplat) in patients during and after an operation compared with conventional ventilation in elderly patients during abdominal surgery. METHODS: Sixty-one elderly patients with American Society of Anesthesiologists (ASA) I to III undergoing open abdominal surgery received either conventional ventilation (8 ml/kg-1VT; CV group) or LPV (VT was adjusted to a target Pplat [⩽ 20 cm H2O]) in the volume-controlled mode with PEEP (9 cm H2O; LPV group) ventilation. RESULTS: Patients in the LPV group showed significantly lower pH values (7.30 ± 0.07 vs. 7.38 ± 0.05, P< 0.001) and respiratory indexes than that of CV group (0.806 ± 0.339 vs. 0.919 ± 0.300, P= 0.043) at the end of surgery. Compared with the CV group, the dynamic lung compliance (33.39 ± 3.163 vs. 30.15 ± 2.572, P< 0.001) was significantly higher, and the body temperature remained significantly more favorable in the LPV group (35.9 ± 0.3 vs. 35.1 ± 0.4, P< 0.001). Patients in the LPV group had significantly faster postoperative recovery than that of the CV group (P< 0.001). CONCLUSIONS: The study showed that LPV could be beneficial for ventilation, core body temperature, and postoperative recovery in elderly patients with healthy lungs.
Unfavorable prognosis and clinical consequences of APOBEC3B expression in breast and other cancers: A systematic review and meta-analysis
Authors: Jafarpour Sima , Yazdi Maryam , Nedaeinia Reza , Ghobakhloo Sepideh , Salehi Rasoul
Published: September 2022

INTRODUCTION:

Controversy exists regarding the association of apolipoprotein B mRNA editing enzyme catalytic subunit 3B APOBEC3B, ( A3B) overexpression and poor prognosis, metastasis, and chemotherapy drug resistance in cancers. Here we conducted a systematic review and meta-analysis to determine its prognostic value and clinicopathological features in breast cancer and some other malignancies.

MATERIALS AND METHODS:

PubMed, Scopus, Cochrane Library, Web of Science, and EMBASE were searched up to Feb 2022 for the association of A3B with breast, ovarian, gastrointestinal and lung cancers. The pooled hazard ratios with 95% confidence interval (CI) were evaluated to assess disease-free survival (DFS), overall survival (OS), and recurrence-free survival (RFS) in cancers under study.

RESULTS:

Over 3700 patients were included in this meta-survey. Elevated levels of A3B were significantly related to low OS (pooled HR = 1.30; 95% CI:1.09–1.55, P < 0.01), poor DFS (pooled HR = 1.66; 95% CI:1.17–2.35, P < 0.01) and poor RFS (HR = 1.51, 95% CI:1.11–2.04, P = 0.01). Subgroup analysis revealed that high A3B expression was associated with poor OS in lung (HR = 1.85, 95% CI: 1.40–2.45), and breast cancers (HR = 1.38, 95% CI: 1.00–1.89). High expression of A3B did not display any significant association with clinicopathologic features.

CONCLUSION:

APOBEC3B overexpression is related to poor OS, DFS and RFS only in some cancer types and no generalized role could be predicted for all cancers.
Return to work of employees with low levels of education: The employers’ role and perspective
Authors: Hoefsmit Nicole , Houkes Inge
Published: September 2022

BACKGROUND: To achieve adequate return to work (RTW) after sickness absence, Dutch legislation prescribes cooperation between absent employees and employers. Yet, we lack insight into how employees with low levels of education exercise influence over (i.e. self-direct) RTW. OBJECTIVE: This study aimed to enhance our understanding of: (A) the role that employers play in the self-direction of employees with low levels of education over their RTW; (B) how employers perceive these employees’ efforts (or lack thereof) to self-direct their own RTW; and (C) how employers understand and interpret the behaviours of these employees. Social cognitive theory served as a framework. METHODS: A qualitative study was conducted with 13 employer representatives using semi-structured interviews. Data were analysed in NVivo12 using a template approach. RESULTS: Employers tend to play a guiding, directive role in employees’ RTW. According to employers, employees generally comply with the employers’ decisions and suggestions, whether or not they have tried to realise their own preferences regarding mode and timing of RTW. Employers interpret such employee behaviours from the perspective of environmental (e.g. financial pressures to RTW) and person-related factors (e.g. sickness and RTW perceptions). CONCLUSIONS: Employers, rather than employees direct the employees’ RTW. Employers should give voice to employees and enable them to have more control over their RTW. Future research should acquire more insight in the employees’ perspective.
Could the academic advisor, intrinsic motivation, and time management influence students’ attitudes towards research work on campus?
Authors: Miraj Muhammad , Chuntian Lu , Rehman Ramiz ur , Osei-Bonsu Robert , Mohd Said Ridzwana , Ali Rizwan , Shereen Saima
Published: September 2022

BACKGROUND: Research is essential and necessary for those who love learning, whether they belong to a research institution or not. Numerous elements influence researchers’ attitudes towards good research work, but in this study we focus on the most significant ones: advisor support, intrinsic motivation, timing, and planning. OBJECTIVES: The current study aims at motivating readers to help improve students’ attitudes towards research work within the university context. METHOD: The target demographic of the current research comprises masters and doctoral students from three major public institutions in Xi’an, China. We aimed to examine the effects of the variables and the study employed correlation and stepwise regression. RESULTS: The results show that advisor support influences attitudes towards research positively and significantly (β= 0.20, p < 0.01). Likewise, intrinsic motivation has a positive and significant effect on attitude towards research (β= 0.18, p < 0.01). Time attitudes significantly influenced attitudes towards research (β= 0.14, p < 0.05). Furthermore, time planning also positively and significantly influenced the attitude towards research (β= 0.15, p < 0.05). CONCLUSION: To achieve an excellent attitude towards research work, students need a cooperative academic advisor who will intrinsically motivate them in their research activities. However, they must manage their academic time and be equipped with time management skills.
Development of a Russian version of the Minnesota low vision reading chart
Authors:   ZRENIE Ophthalmological Clinical Center, St. Petersburg, Russian Federation, Stepanets I.R. , Kulikov A.N. ,   S.M. Kirov Military Medical Academy, St. Petersburg, Russian Federation, Koskin S.A. ,   S.M. Kirov Military Medical Academy, St. Petersburg, Russian Federation, Zhilchuk D.I. ,   S.M. Kirov Military Medical Academy, St. Petersburg, Russian Federation
Published: September 2022

Background: to evaluate reading performance and to obtain comparable results in multi-center studies carried out in several countries, it is necessary to use rigorously developed standardized tests in different languages. Aim: to develop a Russian version of the Minnesota low vision reading chart (MNREAD) and to test it for measuring the near vision reading performance in normally sighted young adults. Patients and Methods: sixty sentences were composed using the most common words selected from the frequency dictionary and the school curriculum of 1st — 4th grades. The number of characters per sentence and the sentence length were adapted to match the MNREAD design principles. 38 sentences were selected. Then, two versions of the test in Russian language (MNREAD-R) with different series of sentences were printed out and tested randomly in 30 subjects aged 18–22 years during one session. The reading parameters were assessed at a 40-cm distance; subjects were asked to read the charts for testing their monocular (right and left eyes) and binocular reading. The measured reading acuity (RA), maximum reading speed (MRS), critical print size (CPS) and reading accessibility index (ACC) were evaluated using statistical analysis. Results: the time taken to read a standardized short test sentence was approx. 3 s. Binocular MRS for test chart 1 was 198±4.51 words/min, for test chart 2 — 200±4.76 words/min; CPS in binocular conditions was the same for both charts and equaled to 0.08±0.02 logMAR; binocular RA for test chart 1 was (-)0.04±0.01 logMAR and test chart 2 — (-)0,06±0,01 logMAR; binocular ACC was 1.00±0.02 and 1.03±0.02, respectively. No statistically significant differences were found between all parameters measured with the use of test charts 1 and 2 (р>0.05). Conclusion: the developed MNREAD-R test charts can be used for Russian speaking population to measure RA, MRS, ACC and RT. Keywords: MNREAD, reading speed, tests to assess reading performance, visual acuity, low vision. For citation: Stepanets I.R., Kulikov A.N., Koskin S.A., Zhilchuk D.I. Development of a Russian version of the Minnesota low vision reading chart. Russian Journal of Clinical Ophthalmology. 2022;22(3):150–155 (in Russ.). DOI: 10.32364/2311-7729-2022-22-3-150-155
Ocular aberrations in keratoconus
Authors:   Research Institute of Eye Diseases, Moscow, Russian Federation, Averich V.V. , Egorova G.B. ,   Research Institute of Eye Diseases, Moscow, Russian Federation
Published: September 2022

The review presents the basic concepts of the wavefront, ocular aberrations and their changes in keratoconus (KC) — the most common form of primary ectatic corneal disorder. It also considers the issues of the posterior corneal surface impact on the indicators of general astigmatism and the wavefront. The authors note that a possible reason for the increase in the aberration level in KC are concomitant signs of dry eye syndrome (DYS). Adding that, the review also discusses methods for correcting aberrations in KC. To date, contact lens vision correction with rigid gas permeable lenses remains the most effective method of visual rehabilitation. The prescription with a combination of artificial tears and reparative medicine allows to almost completely neutralize the phenomena of keratomalacia (conjunctival xerosis). If a patient with KC has initial signs of DYS, it is advisable to use preservative-free low-viscosity artificial tears based on hyaluronic acid of various concentrations. If the patient uses contact lens vision correction to prevent hypoxia complications, it is justified to prescribe the antioxidant agent, methylethylpiridinol, which has an antiaggregational and antihypoxic effect. Keywords: keratoconus, ocular aberrations, posterior corneal surface, wavefront, Zernike polynomials, dry eye syndrome, antioxidant. For citation: Averich V.V., Egorova G.B. Ocular aberrations in keratoconus. Russian Journal of Clinical Ophthalmology. 2022;22(3):168– 174 (in Russ.). DOI: 10.32364/2311-7729-2022-22-3-168-174.
Review of potential simultaneous operations for the surgical rehabilitation of patients with thyroid eye disease
Authors:   Central Clinical Hospital and Polyclinic of the Department for Presidential Affairs, Moscow, Russian Federation, Atarshchikov D.S. , Korchemkina E.Yu. ,   Academy of Postgraduate Education of the Federal Scientific and Clinical Center of the Federal Medical Biological Agency of Russian Federation, Moscow, Russian Federation
Published: September 2022

The importance of revising the traditional multi-stage approach to the surgical rehabilitation of patients with thyroid eye disease is supported by multiple reasons, such as high operation costs, anesthesia-related increase in a burden for patients, and repeated surgical incisions associated with a delayed healing of surgical wounds. Over the past two decades, the orbital surgeons have attempted to solve the problem by combining several operations into a single-stage procedure. The article reviews the results of studies elucidating various simultaneous surgical techniques for orbital decompression, because the surgical treatment of exophthalmos is a "cornerstone" in solving functional problems arising from Graves’ orbitopathy. Moreover, the optimal planning depends on the severity of aesthetic problems in the periorbital region and the associated changes of eyelids and midface. Thus, it is necessary to consider multiple potential solutions within a single anesthesia exposure, the availability of surgeons with the appropriate skills or the involvement of a multidisciplinary team. In conclusion, the authors, referring to their own experience and the latest articles in international editions, propose anatomical and physiological criteria for selecting candidates for simultaneous orbit decompression surgery and for predicting surgical treatment outcomes in such patients. Keywords: orbital decompression, eyelid retraction, simultaneous operations, restrictive strabismus, thyroid eye disease, canthoplasty, exophthalmos. For citation: Atarshchikov D.S., Korchemkina E.Yu. Review of potential simultaneous operations for the surgical rehabilitation of patients with thyroid eye disease. Russian Journal of Clinical Ophthalmology. 2022;22(3):187–190 (in Russ.). DOI: 10.32364/2311-7729-2022-22-3-187-190
Numeric Structure of Genetic Code in Natural Evolution: Energy Grounds
Authors: Moldavanov Andrei
Published: September 2022

It is shown that on the one hand, the track of energy evolution for open systems with conservation links possesses a few pairs of outstanding bifurcation points only, which forms the finite phase structure of energy evolution. On the other hand, for cells, the same process of energy evolution can be described by a limited number of major interchangeable mechanisms of energy metabolism. On this basis, we develop a novel approach for the origin of a numerical skeleton for genetic code (_GC_). It is revealed that, in course of energy evolution, an original _6-_phase structure can be reduced to a _4-_phase one. Alternatively, we observe that energy evolution for cells can be also presented as the random coexistence of three interchangeable metabolism pathways - glycolysis, photosynthesis, and oxidative metabolism. It assumes the existence of the dual essence of the same process of energy evolution. Then, a mathematically correct way to describe energy evolution is to combine two different characteristics of evolution through a combinatorial approach. From a combinatorics standpoint, we have a classic problem for variation of _4 _“balls” over _3 _“bins| which yields _64 _possible scenarios for codon arrangement. Similarly, the number of necessary amino acids at ignorance of the order parameter is _20_. As a result, the suggested approach intuitively combines a few chief known principles of natural evolution into one consistent way – (a) mathematical foundation for the spectral structure of system energy evolution; (b) existence of different but compatible mechanisms of energy metabolism in cells; (c) forming of the numerical structure of _GC_ with the magic numbers _3, 4, 20, _and_ 64_.
Pelatihan Pengolahan Jagung Sebagai Upaya Pemberdayaan Ibu-Ibu di Desa Maskuning Kulon, Bondowoso
Authors: Ningsih Indah Yulia , Dianasari Dewi , Nuri Nuri , Suryaningsih Ika Barokah
Published: September 2022

Desa Maskuning Kulon merupakan salah satu desa di Kabupaten Bondowoso yang tingkat perekonomiannya tidak merata. Salah satu upaya yang dapat dilakukan untuk meningkatkan perekonomian masyarakat adalah melalui pemberdayaan perempuan. Para ibu di desa tersebut diberikan pengetahuan dan dilatih untuk mengolah jagung dan mengemasnya menjadi stik jagung aneka rasa. Berdasarkan hasil pretest dan postest diketahui bahwa terjadi peningkatan pengetahuan para ibu terkait diversifikasi produk olahan jagung. Kegiatan pendampingan dilakukan untuk memastikan bahwa kegiatan produksi dan pemasaran dapat berjalan lancar. Adanya program ini diharapkan dapat memberikan kontribusi dalam upaya peningkatan kesejahteraan masyarakat Desa Maskuning Kulon.
Deleuze and Guattari’s becoming and the Potential for Feminist Criticism of Cultural Content
Authors:   Academic Association of Global Cultural Contents, Han Hee Jeong , Shin Jung-Ah
Published: September 2022

Most feminist criticisms of media content center on patriarchal ideology, highlighting the problem of representation. The concept of becoming, despite its ambiguity in practice, seems theoretically useful for interpreting minority politics, including feminism. Becoming is a concept that drives women’s desires to transcend their traditional role of being secondary to men in the patriarchal system. This article introduces examples of various content to more precisely understand Deleuze and Guattari’s concept of becoming, which has been applied in interdisciplinary ways. In the future, it will be possible to explore feminist micropolitical practice through interpretation and creation of content in connection with Deleuze and Guattari's concept of becoming.
Operations in Synthesized Eight Link Gear Variable Topology Mechanism using Python Programming
Authors: Naveen H. M. , Balli Shrinivas S. , Daivagna Umesh M. , Patil Rashmi
Published: September 2022

This paper illustrates the implementation of python programming in the field of kinematics and helps the planners to visualize the working nature of the synthesized mechanism. In the present context, the authors have considered eight link gear variable topology mechanism in this paper which is synthesized using a complex number approach. This synthesized mechanism is studied using MATLAB programming and the various positions obtained are taken into the consideration for python programming. These advanced tools create an insight among the design engineers on the working nature of the mechanism. The operating condition of the synthesized eight link gear variable topology mechanism in two different phases is analyzed using python programming. This shows the mechanism operating condition in two different phases and validates the output obtained with the help of visualization results in mechanism orientation.
Liver transplantation for fulminant hepatic failure in yellow phosphorus poisoning
Authors: Ravikanti Karthik , Yadav Kiran , Rangappa Pradeep , Jacob Ipe , Rao Karthik , Lochan Rajiv
Published: September 2022

Yellow phosphorus (YP) containing rodenticides is a readily available poison that may be accidentally or deliberately ingested, leading to symptoms ranging from simple gastrointestinal symptoms to fulminant hepatic failure, depending on the amount ingested. As there is no specific antidote, the treatment requires early gastric lavage and institution of supportive measures such as acetyl cysteine infusion and Vitamin K. Progression to fulminant hepatic failure is characterized by rapid deterioration of liver function tests, worsening coagulopathy, and sensorium. The only definitive treatment at this stage is a liver transplant and therapeutic plasma exchange (TPE) can serve as a bridge therapy until a compatible liver donor is found. We present a case of YP-containing rodenticide poisoning, in which the patient progressed to fulminant hepatic failure despite aggressive supportive therapy and was successfully managed with TPE until liver transplantation.
DRESS syndrome: Tricky to diagnose but easy to treat
Authors: Jose Antony , Bhat Smitha , Kumar Hemanth
Published: September 2022

A 27-year-old female presented to us with a short history of fever, jaundice, rash, and worsening hepatic dysfunction subsequent to treatment with intravenous antibiotics and alternative medicine for a urinary tract infection. The eosinophilia, lymphadenopathy, and transaminitis prompted us to consider a diagnosis of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) which can be fatal if not treated. The patient showed improvement in clinical and laboratory parameters after a course of steroids. This case is presented as DRESS syndrome that can prove rapidly fatal if not diagnosed and treated immediately
Apoplexy in Pregnancy
Authors: Vijayakumar Gowtham , Kumar Dhilipan , Sivakumar Sabarish , Ramani Dhivya , Balasubramaniam Rohit , Dhandapani Shankar , Varadharajan Shriram
Published: September 2022

Headache during pregnancy is a common complaint in the emergency room. In pregnancy, pituitary disorders include both hormone active and hormone inactive tumors. Apoplexy may be the first clinical presentation of an underlying pituitary tumor. Red flag signs of presenting symptoms, to be assessed for identifying life-threatening etiology. Various pathophysiological mechanisms have been passed for pituitary apoplexy in pregnancy. Magnetic resonance imaging of the brain is the gold standard investigation. The mainstay of management is the initiation of steroids. Transnasal transsphenoidal removal of the tumor is the definitive treatment that requires a multidisciplinary approach. The indications of surgery are the presence of symptoms due to compression and endocrine abnormalities; however, gestational period should be taken into consideration. We report a case of headache in antenatal women who presented to our emergency room diagnosed with pituitary apoplexy managed with steroids and early surgery, and discharged with good clinical outcome. We recommend a methodical approach to common symptoms that assist in diagnosing forgotten etiology.
Role of cardiac rehabilitation in patient with pulmonary hypertension on functional capacity and quality of life
Authors: Simamora Ronaldo , Chandra Christian Rendy , Ambrari Ade Meidian , Sukmawan Renan
Published: September 2022

Patients with pulmonary hypertension (PH) continue to develop significant exertional symptoms and reduced quality of life despite receiving pharmacological therapy. Guidelines highlighted the importance of rehabilitation as part of management in PH. However, the cardiac rehabilitation program is still underused. We present a case of functional capacity improvement in patients with surgically corrected secundum atrial septal defect (ASD) with PH who underwent cardiac rehabilitation program. A 30-year-old female with a previous history of surgically corrected ASD went to our rehabilitation program in our hospital. She had a 3-weeks program of rehabilitation, and there were improvements in symptoms, clinical parameters, and quality of life after completion of the cardiac rehabilitation program. Rehabilitation can be an adjuvant for pharmacological therapy for PH that has been proven to improve the quality of life in patients with PH
An unusual case of steroid unresponsive Hashimoto’s encephalitis in Indian under-5
Authors: Raut Sumantra , Biswas Antara , Datta Kalpana
Published: September 2022

Hashimoto’s encephalopathy (HE) is a rare entity in children. Usually, it responds very well to steroids. We report a case of steroid-unresponsive HE in a 4-year-old male child presenting with acute encephalitis syndrome with raised intracranial pressure. Serum anti-thyroid peroxidase antibody was high. He was refractory to intravenous immune globulin and steroids. He underwent plasma exchange therapy which had a dramatic response with marked clinical improvement.
Reakatualisasi Nasakh dalam Perspektif Sosiologis
Authors: Muhammad Nashih , Sariyekti Eko , Sumarjoko Sumarjoko
Published: September 2022

Artikel ini tentang reaktualisasi konsep nāsākh yang sangat penting dan relevan berdasarkan kenyataan sosiologis, bahwa dalam waktu kurang dari 22 tahun terdapat beberapa ketentuan hukum awal Al-Qur'an telah mengalami peruberubahan beberapa kali dalam memenuhi kebutuhan masyarakat yang terus berkembang. Perubahan siklus sosial, moral, dan budaya merupakan fakta yang diakui oleh ahli hukum dan dipertimbangkan dalam penentuan teori dan tradisi hukum Islam. Nāskh adalah salah satu gagasan paling relevan di sekitar aturan yang disediakan dalam Al-Qur'an yang menghubungkan firman Tuhan dengan kehidupan orang beriman. Nāsākh menjadi hal yang penting dalam pengembangan metodologi Islam. Pada prinsipnya, ulama Muslim menerima adanya nāsākh, tetapi terbatas pada syariat Islam terhadap syariat samawi sebelumnya. Adapun mengenai adanya nāsākh dalam syariat Islam terutama terhadap al-Qur’an para ulama terdapat perbedaan. Diskursus terhadap pergantian teks hukum (nāsākh) atau tidak adanya pergantian menjadi perdebatan dikalangan ulama fiqh (fuqaha). Persoalan ini sangat penting dalam sejarah perkembangan hukum Islam. Karena terkait langsung terhadap proses pelaksanaan ijtihad oleh ulama ahli fiqh. Pengambilan dan penetapan hukum membutuhkan penalaran logis seorang mujtahid. Berkaitan dengan hal tersebut penulis bermaksud membahas tentang teori nāsākh yang diperlukan dalam kajian hukum Islam dan bentuk-bentuk nāsākh yang dipraktikan oleh ahli fiqh serta bagaimana aktualisasi konsep nāsākh dalam persoalan kontemporer.
Perang dalam Al-Qur`an dan Alkitab
Authors: Ahmadiy Ahmadiy
Published: September 2022

Dalam Islam, peperangan selalu identik dengan kata jihad. Legitimasi terhadap kebolehan berperang pun sering disandarkan pada ayat-ayat yang secara eksplisit memuat kata ini. Ada sebanyak 35 kata jihad dengan berbagai derivasinya yang tersebar di berbagai ayat dan surat yang berbeda. Banyak dalil-dalil nāqli yang berkaitan dengan mulianya menegakkan jihâd fî sabîlillâh bahkan perintah untuk menumbuhkan keberanian mengorbankan harta dan jiwa. Dengan demikian terasa wajar jika seseorang dengan prespektif religious normatifnya sangat antusias mengorbankan jiwa raganya atas nama jihad. Meskipun banyak tujuan jihad dilakukan, namun secara khususnya, kata jihad dimaksudkan untuk i’lâ`an li kalimâtillâh atau mengangkat agama Islam ke derajat tertinggi, membela, dan memeliharanya dari segala upaya perusakan. Secara teknis, jihad dalam Alkitab juga mengandung unsur yang metafisis berupa ketaatan pada Tuhan. Jihad merupakan perjuangan yang tidak dibatasi pada upaya fisik semata tapi termasuk pada perjuangan menjaga ajaran agama. Ayat ini dipertegas dengan ayat II Tim 2:5 dan I Kor 9:25. Ayat tersebut menjelaskan bahwa jihad merupakan kesungguhan yang tidak hanya jiwa tapi juga raga. Sebagaimana jihad dalam Al Quran, interpretasi seruan jihad dalam Alkitab juga tidak benarkan hanya berpijak pada makna literal teks semata. Pemahaman tekstual akan menjadikan perang sebagai pembenaran teologis bagi oknum jihad. Perang yang menghalalkan darah musuh termasuk mereka yang tidak terlibat perang, pembakaran, penjarahan, semua kejahatan kemanusiaan itu (crimes against humanity) bukanlah ajaran yang dimaksudkan oleh agama. Namun, jika interpretasi berhenti disitu, sikap-sikap fundamentalistik dapat menguat dalam penyelesaian masalah melalui kekerasan dan perang. Mengedepankan aspek teologis berarti melestarikan hak asasi manusia.