bluuebunny/crossref_metadata_2025 huggingface dataset:
ERANDADI PINDI IN MANAGEMENT OF VATAJA ABHISHYANDA -A CASE REPORT
Authors: Nimalwar Pallavi Gangadhar , Pradhan Nilakshi Shekhar
Published: February 2025

Vataja Abhishyanda is one of the most common eye disorders affecting people of all ages due to allergens like dust, pollen from trees and grass,
animal dander, chemical scents, etc. It is observed to be a seasonal disease, i.e. during summer and spring. It can be correlated with Allergic
Conjunctivitis based on their signs and symptoms. Abhishyanda (Conjunctivitis) is the root cause of most eye disorders and must be treated early in
effective ways as possible otherwise it may lead to severe complications (Glaucoma, etc.) making the disease unmanageable and would be very
difficult to save the eyesight. Allergic Conjunctivitis has symptoms like itching, burning sensation, watery, mucous, or stringy discharge, mild
photophobia, and eye hyperemia. Modern medicine treats it by administering eye drops and anti-allergic drugs, which may have some adverse
effects. Ayurvedic management of Allergic conjunctivitis has shown some effective results in overcoming the disease with no such effects.
According to Acharya Sharangdhara, Erandadi Pindi was done on the patient, who had symptoms of Vataja Abhishyanda (Allergic
Conjunctivitis) for 7 days. Vata is said to be the predominant Dosha of Vataja Abhishyanda, Erandadi Pindi has Vataghna properties (pacify Vata
Dosha); thus, will reduce the symptoms. The assessment of the condition was done before and after treatment.
ADVANCING PRENATAL CARE: THE ROLE OF PENTA MARKER IN THE FIRST TRIMESTER ANEUPLOIDY SCREENING
Authors: Jindal Ankur , Gupta Geetanjali , Kumar Krishan
Published: February 2025

Aim- The main aim of this present study is to check the performance of five serum marker with ultrasound in first trimester for fetal aneuploidy.
Materials & Method- We screened a cohort of 1159 pregnant women samples whose sample were collected between 11+0-13+6 weeks of
gestation for aneuploidy detection. Levels of β- human chorionic gonadotropin (β-hCG) , pregnancy associated plasma protein-A (PAPP-A), and
alpha-fetoprotein (AFP), placental growth factor (PLGF)and dimeric inhibin (DIA) were determined with using the fluoro-immunometric method
on Auto DELFIA (Perkin Elmer, Turku, Finland). Results were converted to Multiples of the median and final risk was calculated. Results- Total
1159 women screened for combined first trimester screening and their final risk was calculated. Out of 1159 only 17 (1.4%) women showed the
high risk for trisomy 21. Extra 3 markers PLGF, inhibin-Aand AFPwere performed on the same high risk women samples, a separate final risk was
calculated with five markers. Out of 17 only 11(64%) women showed the high risk in penta screening. This expanded screening reduces the false
positive risk up to (36%). Conclusion- This expanded first trimester screening test have high detection rate with less false positive rate
comparatively other screening strategies during first trimester. Apart from high detection rate this screening also helps in the detection of other
pregnancy related complications like- early onset of pre-eclampsia and fetal growth restriction (FGR).
ALDOSTERONE SYNTHASE DEFICIENCY: A CASE REPORT
Authors: Thomas Jessy , M Fahmeeda , Arjun Rohini , Thomas Edwin
Published: February 2025

Aldosterone synthase deficiency is a rare genetic disorder causing congenital hypoaldosteronism. We report a 6-month-old male infant presenting
with failure to thrive and motor developmental delay.Investigations revealed severe hyponatremia,hyperkalemia,metabolic acidosis,normal
cortisol and 17-hydroxyprogesterone levels.Notably, his low aldosterone level, low 18 hydroxycorticosterone level, and high plasma renin activity
were suggestive of aldosterone synthase deficiency. Genetic analysis confirmed the diagnosis.Treatment with fludrocortisone replacement and
sodium supplementation normalized electrolyte levels. On subsequent follow up, the infant demonstrated remarkable improvement with
fludrocortisone maintenance therapy,exhibiting catch up weight gain and achieving age appropriate developmental milestones.
A CASE REPORT OF PREGNANCY IN NONCOMMUNICATING RUDIMENTARY HORN OF UTERUS
Authors: Ashok Randive Snehal , Padmawar Atul , Kedar Kshama
Published: February 2025

Background: A uni-cornuate uterus with a rudimentary horn is a uterine anomaly resulting from the incomplete development of one of the
müllerian ducts and an incomplete fusion with the contralateral side. Pregnancy in a rudimentary horn of the uterus is a rare clinical condition with a
reported incidence of 1 in 100,000 to 140,000 pregnancies. Usually, the diagnosis is missed and may present as an emergency with haemoperitoneum. The standard treatment is the surgical excision of the horn. Case Report: A gravida 3, para 2, live2 patient presented at 11.5 weeks'
gestation with scan suggestive of right sided live ectopic pregnancy in the non-communicating rudimentary horn of uterus which had been detected
on routine antenatal ultrasound. She underwent a exploratory laparotomy and the pregnancy was found in the right non-communicating
rudimentary horn of the uterus with right rudimentary horn excision. The final diagnosis of a non-communicating rudimentary horn pregnancy was
made intraoperatively. Conclusion: This case highlights the importance of an early ultrasound in detecting uterine anomalies and the need for high
clinical suspicion.
KNOWLEDGE, ATTITUDE AND PRACTICE STUDY ABOUT BRUCELLOSIS IN OCCUPATIONALLY EXPOSED HIGH RISK GROUPS- VETERINARIANS, MILKMEN AND MEAT HANDLERS - IN TERTIARY LEVEL HOSPITAL OF WESTERN RAJASTHAN
Authors: Verma Usha , Prakash Prabhu
Published: February 2025

Background:-Brucellosis is recognized as a significant zoonotic infection globally. Improving the occupational worker's Knowledge, Attitude,
and Practice (KAP) is a key factor in the effective prevention and control of brucellosis. This study is aimed to analyze knowledge, attitude and
practice for brucellosis among high-risk populations (Veterinarians, Milkmen and Meat handlers). Material and Method:-A cross-sectional
study was conducted on 510 high risk population (220 milkmen, 90 veterinarians & 200 meat handlers) chosen randomly from Jodhpur, Rajasthan.
A self-administered pre-tested questionnaire was used to access KAP study and their responses were collected and the data were entered into
Microsoft Excel and analyzed using SPSS. Result:- 67.68% milkmen, 83.71% veterinarians & 62% meat handlers had knowledge about causes
and modes of transmission of brucellosis through consumption of raw milk, pasteurized cheese, raw meat, prevention of brucellosis through
exposure to aborted fetuses , placental fluid and vaccination. A positive attitude towards brucellosis was observed in 174 (79.09%) milkmen, 89
(98.88%) veterinarians, and 147 (73.5%) meat handlers. When data about practice were analyzed their response level ranges from 2-100% in
veterinarians and 0-100 % in milkmen and meat handler both. All participants in subgroup milkmen and meat handlers had zero practice of wearing
mask, eye gears, while handling animal's excreta and during deliveries. Whereas 24(12%) and 18(9%) meat handlers were wore gown and gloves
respectively. During gestation, most veterinarians do not use all the essential personal protective gears, only 53(58.88%) using gown, 25(27.77%)
using gloves, 2(2.22%) using goggles, and 43(47.77%) using masks. 164 (74.54%) milkmen and 174(87%) meat handlers had practice of good
hand washing whereas 53(24.09%) milkmen and 3(11.50%) meat handlers were disposed waste properly. In veterinarians 100% had proper hand
washing technique practice while only 27(30%) had practiced for proper waste disposal. Conclusion:-Among the high-risk population, there is a
lack of complete knowledge, attitude, and set of practices about Brucella infection. Regular Training and health education on Brucellosis is
essential for high risk population as it is a preventable zoonotic disease with a high prevalence in Western Rajasthan.
APPLICATION OF NOLLA'S METHOD FOR AGE ESTIMATION: A CBCT STUDY ON MAXILLARY SECOND MOLARS AND CANINES IN THE RAJASTHAN POPULATION
Authors: Gahlot Prajjawal , Chaudhary Pankhuri , Sundaragiri Krishna Sireesha , Sobti Geetika , Thanvi Jayshree
Published: February 2025

The study aimed to assess the correlation between dental age and chronological age using Nolla's radiographic method, specifically evaluating
mineralization stages of maxillary canine and second molar for sub-adult tooth age estimation. This retrospective single-centre study, conducted at
the Department of Oral Medicine and Radiology, RUHS College of Dental Sciences in Jaipur, Rajasthan, aimed to assess age using Cone Beam
Computed Tomography (CBCT) scans. CBCT scans of thirty patients (15 males, 15 females), aged 8 to 14 years were randomly selected and
evaluated, focusing on developmental stages of maxillary canine and second molar for dental age estimation. Inclusion criteria ensured
participants' oral health and normal growth, while exclusion criteria ruled out systemic diseases, congenital anomalies, and dental pathologies.
Statistical analysis employed SPSS Version 29, utilizing one-way ANOVAfor intergroup comparisons. Results, presented as P values and F-static
values, highlighted the study's precision in dental age estimation. Dental age was estimated using CBCTwhile categorizing subjects aged 8-14 into
six subgroups (1-6). Group-wise analysis revealed non-significant differences between chronological and dental age. Molar and canine dental age
showed overall underestimation, with subgroup variations. The reliability of dental age, evaluated particularly through Nolla's method,
underscores its efficacy as a trustworthy indicator for assessing dental maturity. The demonstrated validity of Nolla's dental age estimation further
solidifies its utility as a robust dental maturity indicator.
RECURRENT BRAIN GLIOMA- SURGERY AND CLINICAL OUTCOME
Authors: Shrivastava Amit , Verma Srishti , Shaikh Heena , Mathur Ashish
Published: February 2025

Introduction: Gliomas account for 24% of all primary brain and CNS tumors. Histologically, gliomas were categorized into sub types and grades
(I through IV). Low-grade gliomas are grade I and grade II, while high-grade gliomas are grade III and grade IV. The gold standard for treatment of
high-grade glioma is the most extensive safe surgical resection followed by radiotherapy combined with chemotherapy. However, recurrence of
glioma is inevitable. Management of recurrent cases is still controversy. Aim & Objective: The purpose of this research was to examine the
efficacy of reoperation for cases of recurrent glioma in improving patients' outcome. Methods: This study included 40 patients with recurrent
glioma admitted and operated. Results: There were 28 male (70%) and 12 female (30%), their age incidence ranged from 20 to 75 years with a
mean age of 48.06, gross total resection of recurrent cases could be done in 24 (60%) patients, subtotal resection in 10 (25%) and partial in 6 (15%),
all of recurrence were found at the same site almost the same of primary tumor except that two cases were radionecrosis and one patient revealed
aggressive transformation from anaplastic astrocytoma to GBM by the end of the study period, and 26 (65%) patients alive and 14 (35%) died.
Conclusion: Surgical management of recurrent gliomas in selected patients is generally associated with improved functional performance and
prolonged survival. Patients' Karnofsky score at recurrence is an important prognostic factor for both low-grade glioma and high-grade glioma.
CLINICAL SPECTRUM OF COVID-19 AND RISK FACTORS ASSOCIATED WITH SEVERITY IN TAMIL NADU CHILDREN
Authors: K M Santhosh
Published: February 2025

Aim: To assess the clinical spectrum of COVID-19 in children and the risk factors associated for hospitalisation and admission during the
pandemic. Methods: This cross-sectional study was conducted from April 2020 to August 2020 with children between one month and 18 years of
age. Detailed information was collected including demographic data, contact history, travel history, living conditions and symptoms. Patients
underwent baseline laboratory parameters and chest radiograph was done with respiratory symptoms. Results: Out of 201 children with features
suggestive of COVID-19, 79 were tested positive with RT-PCR. Most common symptoms included fever in 25 (80.64%), cough in 16 (51.61%),
sore throat in 10 (32.25%) and lymphadenopathy in 6 children (19.35%). On Chest X-ray, 2 cases had disseminated consolidations, 2 had
interstitial pneumonia and one had disseminated nodular changes with interstitial infiltrates and ground-glass opacities. Conclusion: A milder
disease pattern is seen in majority of children with COVID-19. Risk factors for PICU include specific comorbidities as diabetes mellitus, asthma,
liver disease, and cardiac disease and raised inflammatory biomarkers.
PERIARTICULAR RFA: AN INNOVATIVE METHOD FOR TREATING PAIN IN BERTOLOTTI'S SYNDROME – A CASE REPORT
Authors: Pandian M Karthik , Kumar Ajit , Gupta Sukhdeo , D Sadhankar Abhilash , M Sridhar
Published: February 2025

A 45-year-old woman had a 12-month history of low back pain and left upper buttock pain, which did not respond to conservative management.
Bertolotti's syndrome, characterised by a unilateral lumbosacral transitional vertebra, was diagnosed based on radiological findings. The patient
underwent a diagnostic block, resulting in immediate pain relief lasting 10 hours. Given the positive response, she proceeded to conventional
radiofrequency (RF) ablation of the left pseudoarthrosis. Following the procedure, the patient experienced a significant reduction in pain that
persisted for over four months. Functional ability and quality of life also improved markedly. Importantly, no significant complications occurred
during or after the intervention. RF ablation offers a promising and minimally invasive therapeutic option for patients with Bertolotti's syndrome
who have refractory back pain unresponsive to conservative measures. This case highlights the role of interventional techniques, such as RF
ablation, in achieving long-term pain relief and improving quality of life in individuals with Bertolotti's syndrome.
SURGICAL SITE INFECTIONS IN ABDOMINAL SURGERIES PREVALENCE, RISK FACTORS, AND BACTERIAL PROFILE- A PROSPECTIVE CROSS-SECTIONAL STUDY
Authors: Jayalal J. A. , Ajish Jolly S. A.
Published: February 2025

Introduction: Surgical site infections (SSIs) are a primary cause of unfavorable consequences following surgery. A local pattern must be known in
order to design a successful hospital infection program. The management of SSIs has become difficult due to the constantly shifting pattern of
infections and the improper use of antibiotics, which has led to the emergence of drug-resistant strains. The study's goals are to determine the most
frequent organisms and risk factors linked to SSIs, as well as to estimate prevalence. During a six Methodology: -month study period, this
analytical cross-sectional study assessed the associations between different risk factors and the occurrence of SSIs in patients who underwent
elective surgery and remained in the Department of General Surgery at least seven days after surgery. We used modified CDC criteria to diagnose
SSIs. In cases of probable subsequent septicemia, we collected blood following the wound. We cultured blood samples on brain-heart infusion
broth while we cultured pus on MacConkey and blood agar. We used Mueller-Hinton agar and the Kirby-Bauer method to test for antimicrobial
sensitivity. In 13 out of 50 postsurgical wound infections, Gram-negative organisms outnumbered Gra Results: m-positive ones. Age, BMI, wound
class, American Society of Anesthesiologists (ASA) score, preprocedural WBC count > 10,000, and surgical time are the risk factors linked to this
study. Escherichia coli causes the majority of infections (45.7%). This investigation identified gram-negative bacteria that produced extendedspectrum lactamase (ESBL). The majority of microbes were multidrug resistant. Overall, 26% of gastrointestinal procedures resulted in SSIs,
according to the current study. Hospitals can develop a successful antibiotic prophylactic policy by using the sensitivity and resistance patterns of
the isolated bacteria.
AN UNSUAL CASE OF SECONDARY HYPERTENSION IN AN ADOLESCENT FEMALE.
Authors: Praharsha Y.S. , Naik Vivek , Manusha A. , Reddy K. Ravinder
Published: February 2025

Coarctation of the aorta (CoA) is a congenital narrowing of the aorta that often goes undiagnosed until adolescence or adulthood, leading to
secondary hypertension. We report a case of seventeen year old female with CoA, presented with complaints of claudication in lower limbs and
persistent headache. Coarctation was noted distal to the left SCA on 3D CT angiogram. Resection of the coarcted segment and end to end
anastomosis with Dacron graft led to normalisation of blood pressure and resolution of symptoms on follow up. This case emphasizes the
importance of considering CoA in the differential diagnosis of adolescents with secondary hypertension, it's early diagnosis and repair.
ONLINE SHOPPING BEHAVIOR AND ITS IMPACT AMONG UNDERGRADUATE STUDENTS IN INDIA
Authors: George Litna , Roy Akansha , Anamika Anamika , Besra Anjali , Kumari Anjali , Bharati Ankita , Kumari Arti
Published: February 2025

Background: Online shopping is one of the common modes of purchase among students; at the same time, it can cause a significant impact on
them. Objective: To assess the online shopping behavior and its impact among undergraduate students. Methods: 150 undergraduate students
from various professional and non-professional colleges in Rachi, Jharkhand, participated in this cross-sectional study. Samples were selected
using a simple random sampling method. We collected data using a demographic proforma, a self-structured questionnaire, and a five-point rating
scale. The data were analysed using SPSS version 16.0 and Jamovi version 2.3.28. Frequency and percentage, mean and standard deviation, and the
Kruskal-Wallis test were used. Results: The study showed that the majority of the samples shopped more than twice annually (78%) and favored
Flipkart (65.3%) over other online shopping platforms, with fashion accessories accounting for the majority of purchases (42.7%). The study's
findings indicate that the majority of the sample made purchases based on product quality (74.0%), while 56.0% expressed a preference for online
shopping because it eliminated the need for travel. The study also found online shopping sites that provide high security have the highest mean and
standard deviation (11.4 + 2.20), closely followed by convenience (11.1 + 2.47). The study also found a substantial psychological impact due to
online shopping among undergraduate male and female students. (χ² 4.443, p 0.035, ε² 0.02982). Conclusion: Online shopping has become a
ubiquitous part of undergraduate life, offering both benefits and challenges. By fostering financial literacy and responsible consumer habits,
students can enjoy the advantages of e-commerce without compromising their well-being.
BIOCHEMICAL ROLE OF MAJOR MINERALS IN PREECLAMPSIA
Authors: V. Virkhede Kanchan , M. Rewatkar Monali , Ghate Neha , S. Domke Narendra
Published: February 2025

Background - Preeclampsia is pregnancy-specific, multi-systemic syndrome of widespread endothelial malfunction and vasospasm developing
after 20 weeks of gestation, defined by hypertension(BP>140/90 mm Hg), fluid retention and proteinuria. Imbalances in serum sodium and
potassium causes vasoconstriction and hypertension in PE. Hypocalcemia stimulates parathyroid hormone, causing vasoconstriction. Magnesium
regulates blood pressure by monitoring vascular tone and structure. Material And Methods- Analytical cross-sectional study conducted at
biochemistry department IGGMC Nagpur, includes 150 pregnancies. Serum Electrolytes, Magnesium, Calcium level were estimated on auto
analyzer and compared between two groups. students t –test was used to see the level of significance( P < 0.01). Result- Serum
sodium(142.17±5.66 mmol/L and 136.13±4.17 mmol/L), potassium(3.45 ± 0.54 mmol/L and 3.98±0.36 mmol/L), Magnesium(1.530±0.299 and
1.742±0.226) and calcium(7.9±0.4 and 9.7±0.7) observed in preeclamptic and normotensive respectively. (p < 0.05) . Conclusions - Estimation of
serum electrolytes, calcium and during pregnancy could help in early detection and prompt treatment of preeclampsia.
COMPREHENSIVE ANALYSIS OF TRUS-GUIDED PROSTATE BIOPSY: EFFECTS ON ERECTILE AND URINARY FUNCTIONS
Authors: Rakshit R Rajath , R Pudakalkatti Sanjay , R Keshavamurthy
Published: February 2025

Background: Transrectal ultrasound-guided prostate biopsy (TRUS) is a widely used diagnostic method for prostate cancer. Although effective,
the procedure's effects on erectile function, lower urinary tract symptoms (LUTS), and voiding function remain a concern. This study evaluates
these outcomes to inform clinical practice. Methods:Aprospective analysis was conducted on patients undergoing TRUS-guided prostate biopsy.
Erectile function was assessed using the International Index of Erectile Function (IIEF), LUTS with the International Prostate Symptom Score
(IPSS), and voiding function using Qmax. Results:The mean age of participants was 70.07 years, with an acute urinary retention (AUR) incidence
of 7.7%. Post-biopsy, the IPSS increased significantly from 18.89 to 22.91 (p < 0.001), while Qmax decreased from 18.77 mL/s to 16.61 mL/s (p <
0.001). The IIEF scores showed minimal change from 15.96 to 15.87 (p = 0.036). Conclusions: TRUS-guided prostate biopsy significantly
impacts LUTS and voiding function in the short term but has a negligible effect on erectile function. Enhanced patient counseling and biopsy
templates are crucial for mitigating these effects.
EVALUATING OF THE ANTIBACTERIAL EFFICACY OF PROSOPSIS JULIFLORA AND THREE COMMERCIALLY AVAILABLE MOUTHRINSES: AN IN VITRO STUDY
Authors: B Ravisankar. , Kalaiarasi Kalaiarasi , S Kalaivani. , K Rajeswary.
Published: February 2025

Immunocompromised individuals are more likely than the general population to get oral and periodontal infections. These conditions, which
impact the tissues around teeth, are typically brought on by inadequate dental hygiene, which results in the accumulation of plaque, which harbours
a number of bacteria. Although many medications and synthetic compounds on the market appear promising, it is well recognised that continuous
usage of these medicines might result in adverse side effects. For this reason, Prosopis juliflora leaf extract is used instead. Unlike commercial
mouthrinses, the goal is to test for and evaluate the antibacterial effectiveness of P. juliflora crude extract against periodontal and oral infections.
Instat Plus was used to calculate the data, and MIC was used to measure the antibacterial activity. It was shown that, in comparison to other
commercial mouthrinses, P. juliflora was the most effective mouthrinse against particular microorganisms. The findings of this investigation
unequivocally show that P. j. crude extract
UNRAVELING NIEMANN–PICK TYPE C: A RARE CAUSE OF NEUROPSYCHIATRIC SYMPTOMS
Authors: Patel Shrujal
Published: February 2025

Background: Niemann–Pick type C (NP-C) is a rare autosomal recessive lipid storage disorder caused by NPC1 or NPC2 gene mutations. It
presents with varied symptoms, including hepatic, neurological, and psychiatric features, making diagnosis challenging. A 33- Case Presentation:
year-old woman with neuropsychiatric symptoms, initially misdiagnosed as schizophrenia, presented with tremors, rigidity, and cerebellar ataxia.
Neurological findings, including vertical supranuclear gaze palsy, and genetic testing confirmed NP-C with a pathogenic NPC1 variant. Despite
symptomatic treatment, neurological deficits persisted. This case highlights the need for early reco Conclusion: gnition of NP-C in patients with
neuropsychiatric symptoms. Routine use of biomarkers and genetic testing can improve diagnostic accuracy and outcomes, particularly in highrisk populations.
Sexual Dimorphism of Human Sternum in the Population of Bangladesh: A Morphometric Analysis
Authors: Jahan Isot , Tahmina Mousomi , Leeza Nafrina Islam , Islam Nazia Binte , Khan Maria , Fatima Kaniz , Rahman Fariha
Published: February 2025

Background: The sternum exhibits notable sexual dimorphism and serves as a valuable tool in forensic sex determination. However, population-specific standards are essential for accurate assessment. This study aimed to analyze sexual dimorphism in human sterna from the Bangladeshi population through comprehensive morphometric analysis. Methods: We examined 150 dry adult human sterna (85 male, 65 female) collected from Dhaka Medical College from January 2022 to December 2022. Multiple parameters were measured using digital slide calipers, flexible wire, and analog micrometers, including lengths, breadths, and thicknesses of the manubrium and mesosternum. Shape variations were documented, and various indices were calculated. Statistical analysis was performed using unpaired Student's t-test, with significance set at p<0.005. Results: Significant sexual dimorphism was observed in most direct measurements. The manubrium length (male: 49.06 ± 1.59 mm, female: 41.85 ± 1.20 mm), mesosternum length (male: 99.89 ± 2.27 mm, female: 85.73 ± 1.84 mm), and manubrium volume (male: 27204.71 ± 1476.81 mm³, female: 18083.79 ± 1124.34 mm³) showed particularly strong dimorphism (p<0.001). Trapezoid-shaped manubrium was predominant in both sexes (male: 80.00%, female: 75.40%). Interestingly, while direct measurements showed significant differences, derived indices such as the manubrium index and sternal angle showed no significant sexual dimorphism. Conclusion: This study establishes population-specific standards for sternal measurements in the Bangladeshi population. The findings suggest that direct measurements, particularly of manubrium and mesosternum lengths, provide more reliable indicators for sex determination than derived indices. These results have important applications in both forensic anthropology and clinical practice, particularly in thoracic surgery planning.
The Impact of the February 6 Kahramanmaraş Earthquake Disaster on Breast Cancer
Authors: UGUR Mustafa , DUMAN Nesip , ERDEM Mehmet , DAL Mehmet Burak , KARA Bircan , TEMİZ Muhyittin
Published: February 2025

Introduction: This study was conducted in a province located in southern Turkey, which experienced extensive destruction due to major earthquakes on February 6, 2023. Since a significant portion of healthcare facilities were destroyed or severely damaged, the remaining healthcare facilities and field hospitals established had to primarily focus on providing emergency medical services. Consequently it became evident that patients with breast-related complaints faced difficulties accessing appropriate healthcare centers. This study was designed to investigate the impact of the earthquake on breast cancer, to enable predictability of outcomes in similar situations, and to take preventive measures. Materials and Methods: The medical records of breast cancer patients diagnosed and treated at our hospital during the 15-month periods before and after the February 6, 2023, earthquake were retrospectively reviewed. The patients' age and tumor stages were determined and compared. Results: A total of 274 patients were included in the study, comprising 191 patients diagnosed with breast cancer before the earthquake and 83 patients diagnosed after the earthquake. It was found that the mean age of patients presenting after the earthquake was lower (p<0.005). Additionally, and disease stage were found to be higher in patients presenting after the earthquake (p<0.005). Conclusion: The observation of breast cancer in a younger age group during the post earthquake period may be attributed to patients with symptoms being unable to Access appropriate healthcare facilities after the disaster or to older age groups being unable to reach healthcare institutions. The increase in disease stage was linked to the unavailability of suitable healthcare facilities following the disaster. To address these issues, mobile healthcare teams should be trained, and well-equipped vehicles should be prepared during disaster preparedness phases.
Glaucoma Patterns among Patients at a Tertiary Eye Hospital
Authors: Alam Dr. Md. Kibria , Matin Dr. Md. Abdul
Published: February 2025

Background: Glaucoma is a major cause of irreversible blindness worldwide, with a variety of subtypes such as primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG), and secondary glaucomas, each with distinct pathophysiological mechanisms and treatment challenges. The prevalence and patterns of glaucoma vary geographically, with PACG being more common in Asian populations. Early detection and management are crucial in preventing blindness, particularly in resource-limited settings where delayed diagnosis is common. Objective: This study aims to analyze the patterns of glaucoma among patients at a tertiary eye hospital in southern Bangladesh, focusing on the distribution of different glaucoma subtypes, demographic trends, and clinical characteristics. Methodology: A prospective observational study was conducted at the outpatient department of Sheikh Fazilatunnessa Mujib Eye Hospital & Training Institute (SFMEHTI), Gopalganj, Bangladesh, from January to December 2019. All patients presenting with glaucoma or suspected glaucoma were included. Data were collected on age, clinical diagnoses, symptoms, ocular examination findings, intraocular pressure (IOP), gonioscopic findings, and visual field tests. The glaucoma subtypes were classified based on the clinical presentation and diagnostic results. Results: The most common types of glaucoma were PACG (45%), POAG (32%), and lens-induced glaucoma (LIG) (12%). Other types included normal tension glaucoma (NTG) (6%), juvenile glaucoma (2%), congenital glaucoma (1%), neovascular glaucoma (NVG) (1%), and aphakic and others glaucoma (1%). At the time of presentation, 47% of patients had normal vision, 30% had visual impairment, 14% were severely visually impaired, and 5% were blind. The mean IOP was 26.29 mmHg in the right eye and 26.37 mmHg in the left eye. Gonioscopy revealed that the majority of patients had narrow angles, with a smaller percentage showing open or closed angles. Conclusion: Primary ...
A Correlation Study on Health Promoting Life Style Factors with Quality of Life and Self-Esteem among Arthritis Patient from a Selected Hospital of Bagalkot
Authors: B Aishwarya , Ayyub Ayyub , J Aleetta , Rohini Rohini , Sarojini Sarojini , H. Abhishek , I. Prashanth , B. Amruta. , Natekar Dr. Deelip S.
Published: February 2025

Background of the study: Patients with inflammatory rheumatic diseases (IRDs) often express their desire to ensure the success of medical treatment or to replace anti rheumatic drugs, at least partially, by changing lifestyle factors. This desire is fostered by the plethora of media reports that describe the influence of nutrition, body weight, physical fitness and stress level on health and life expectancy Aim: To find the correlation between health promoting life style factors, quality of life and self-esteem among arthritis patient from a selected hospital of Bagalkot. Materials and methods: Purposive sampling technique was used to select the 150 samples. Health promoting life style factors, quality of life and self-esteem was assessed by standardized scales. Results: among 150 samples of arthritis patients 88 samples had low self-esteem, 79 samples had moderate quality of life, regarding health promoting life style factors moderate amount of general life style is about 119(79.33%), good were 31 (20.66%), and there is no poor amount of general life style. Health responsibly is moderately about 110(73.33%), good were 33(22%) and poor amount of 7(4.66%). Physical activity among arthritis patient is moderately about 110(73.33%), good amount of physical activity is about 20(13.33%), and poor amount of 20(13.3%). In this study good amount of nutrition is about 75(50%), moderate amount of 67(45.66%) and poor were 8(5.33%). The moderate amount of spiritual growth is 108(72%), good were 42(28%) and there is no poor spiritual growth. The moderate amount of 108(72%) is reported, in the study of interpersonal relationship among people is moderately 104(69.33%), a good amount of 45(30%) and in poor were 1(0.66%). The stress management is moderately managed about 108(72%), a good amount of stress management is about 42(28%) and there is poor amount stress management in health promoting life style factor among arthritis patient. There is a significant correlation between ...
Role of Parents in the Care of Mentally Challenged Children in the Selected Special School of Bagalkot
Authors: Sajian Mr. Santosh B. , Natekar Dr. Deelip S. , Laxmi Ms. , Swati Ms. , Devika Ms. , D Ms. Triveni, , Meenakshi Ms. , Girimallapa Mr. , Vijaykumar Mr.
Published: February 2025

Introduction: All parents wish for healthy baby, but some parents though not by their choice are forced into a situation of having child with mental retardation. The birth of child with a disability, or the discovery that a child a disability can have profound effects on the family. “But Every child is special”. Having a child with disability in a family is not the same having achild without disability. But above all parents are the directly affected population and also are the prime care-takers to provide life long support and security to the mentally retarded persons [1]. Method: An non experimental descriptive survey study, the sample of the present study comprises mentally challenged children residing in special school of Bagalkot. A non-probability purposive sampling technique was adopted to select samples in the present study. The sample comprises 50 parents of mentally challenged children. The data were collected by using closed ended questionnaires for socio demographic variables of parents of mentally challenged children, self administrated knowledge to assess the role in the care of mentally challenged children. The data obtained analyzed with help of descriptive and inferential statistics. Results: Finding related to the assessment of role of parents in care of mentally challenged children reveled that psychosocially majority (86%) of parents were moderate psychosocial well being, (10%) of parents were high psychosocial well being and (4%) were poor psychosocial well being. Economically majority (58%) of parents were having average financial stability, (24%) of parents were having moderate financial stability and (2%) of parents were having poor financial stability. In daily routine activities majority (50%) of parents were following adequate daily routine activity, and other (50%)of parents were following moderate daily routine activity. Psychosocially the mean and SD of parents of mentally challenged children (21.6±4.34) respectively. Economically ....
Analysis of the Influence of Marketing Strategy 4.0 on Consumer Satisfaction and Repurchase Intention of RTD Products in the Carbonated Soft Drink Category
Authors: Dewi Aprilyta Gadis Nabilla
Published: February 2025

This study aims to analyze the impact of the Marketing 4.0 strategy on consumer satisfaction and repurchase intention for Ready-to-Drink (RTD) carbonated soft drinks (CSD). Marketing 4.0, introduced by Kotler, Kartajaya, and Setiawan, integrates digital and traditional marketing through four key elements: Brand Identity, Brand Image, Brand Integrity, and Brand Interaction. The research uses Partial Least Squares - Structural Equation Modeling (PLS-SEM) with 524 respondents, who are CSD consumers in Indonesia. The results show that Brand Identity, Brand Image, and Brand Integrity have a positive and significant impact on consumer satisfaction, while Brand Interaction has a positive but non-significant impact. For repurchase intention, Brand Image, Brand Integrity, and Brand Interaction have a positive and significant effect, while Brand Identity has a negative but non-significant impact. Cross-tabulation analysis reveals a significant relationship between consumer satisfaction, repurchase intention, and demographic factors such as age, purchase location, and purchase frequency. This study offers practical insights for marketers to develop more effective strategies to enhance consumer loyalty and provides academic contributions regarding the relevance of Marketing 4.0 for low involvement products.
Pengaruh E-commerce, Perilaku Konsumtif Nasabah dan Penggunaan Digital Aplikasi Terhadap Kualitas Produk Jenius Bank BTPN Kantor Cabang Palembang
Authors: Primaza Fitria Naztha , Wadud Muhammad
Published: February 2025

Kualitas produk menjadi salah satu faktor penting dalam mempertahankan daya saing perusahaan di era digital, termasuk pada Bank BTPN Kantor Cabang Palembang. Penelitian ini bertujuan untuk menganalisis pengaruh E-commerce, Perilaku Konsumtif Nasabah, dan Penggunaan Aplikasi Digital terhadap Kualitas Produk. Menggunakan metode kuantitatif dengan pendekatan deskriptif, penelitian ini melibatkan 370 nasabah prioritas sebagai populasi, dengan sampel sebanyak 111 responden yang diambil menggunakan teknik probability sampling. Data dikumpulkan melalui kuesioner berbasis skala Likert serta dilengkapi dengan data sekunder dari studi pustaka. Analisis data dilakukan menggunakan uji regresi linear berganda dan uji asumsi klasik dengan bantuan SPSS versi 26. Hasil penelitian menunjukkan bahwa secara parsial, E-commerce, Perilaku Konsumtif Nasabah, dan Penggunaan Aplikasi Digital masing-masing berpengaruh signifikan terhadap Kualitas Produk, dengan nilai signifikansi masing-masing 0,000, 0,014, dan 0,000. Secara simultan, ketiga variabel tersebut juga berpengaruh signifikan terhadap Kualitas Produk, dibuktikan dengan nilai signifikansi F sebesar 0,000. Kesimpulannya, E-commerce, Perilaku Konsumtif, dan Penggunaan Aplikasi Digital berperan penting dalam meningkatkan persepsi nasabah terhadap kualitas produk. Implikasi dari penelitian ini adalah bahwa perusahaan perlu memanfaatkan teknologi digital secara lebih efektif, meningkatkan pengalaman pelanggan melalui aplikasi yang user-friendly, serta memahami perilaku konsumtif nasabah untuk menciptakan strategi pemasaran yang lebih tepat sasaran. Strategi ini diharapkan dapat meningkatkan kepuasan nasabah dan daya saing perusahaan di tengah persaingan industri perbankan yang semakin kompetitif.
Meningkatkan Harga Saham Melalui Analisis Kinerja Keuangan pada Bank Himbara yang Tercatat di Bursa Efek Indonesia
Authors: Suryaningtiyas Hendrarini
Published: February 2025

Penelitian ini bertujuan untuk menganalisis pengaruh kinerja keuangan terhadap harga saham Bank Himbara yang tercatat di Bursa Efek Indonesia (BEI) selama periode 2018-2022. Bank Himbara, yang terdiri dari bank milik negara, memiliki peran penting sebagai lembaga intermediasi keuangan dalam perekonomian Indonesia. Dengan menggunakan data sekunder berupa laporan keuangan kuartalan dan data historis harga saham, penelitian ini memfokuskan pada enam rasio keuangan utama: Capital Adequacy Ratio (CAR), Return on Equity (ROE), Return on Assets (ROA), Non-Performing Loans (NPL), Net Interest Margin (NIM), dan Loan to Deposit Ratio (LDR). Analisis dilakukan untuk mengidentifikasi hubungan antara rasio-rasio tersebut terhadap perubahan harga saham, serta dampak kenaikan harga saham terhadap dinamika pasar saham bank Himbara. Metode penelitian yang digunakan meliputi analisis regresi linier berganda untuk mengukur pengaruh rasio keuangan terhadap harga saham dan uji statistik untuk mengevaluasi signifikansi hubungan tersebut. Hasil penelitian menunjukkan bahwa rasio keuangan seperti ROE dan ROA memiliki pengaruh positif signifikan terhadap harga saham, sementara rasio NPL memiliki dampak negatif. Selain itu, peningkatan harga saham mempengaruhi volatilitas harga saham, meskipun dampaknya berbeda antar bank. Penelitian ini memberikan kontribusi empiris bagi investor dalam menilai kesehatan keuangan bank sebagai faktor dalam pengambilan keputusan investasi. Selain itu, hasilnya dapat digunakan sebagai acuan oleh akademisi dan praktisi untuk memahami dinamika pasar modal selama periode krisis.
Study on the utilization of jamblang (Syzygium cumini L.) bark extract as a herbal-based alternative hair dye
Authors: Muzakkir Muzakkir , Sembiring Fanny Rizki , Indriana Meutia , Salman Salman
Published: February 2025

Hair dye is a cosmetic product used to restore or alter hair colour. Research on herbal-based hair dyes has expanded with the growing interest in natural ingredients. The bark of the jamblang tree (Syzygium cumini L.), which produces a black pigment, has long been utilised in various crafts. This potential makes it a candidate for natural hair dye. This study examines the use of ethanol extract from jamblang bark in the formulation of herbal hair dye and its effectiveness in producing a black colour. The research aims to investigate the utilization of ethanol extract from jamblang bark (Syzygium cumini L.) as an herbal hair dye. The focus is on evaluating the extract's effectiveness in a formulation with pyrogallol, copper (II) sulfate, and xanthan gum, as well as determining the optimal concentration to achieve black hair colour. The method for preparing the hair dye formulation involved the use of ethanol extract from jamblang bark in varying concentrations of 5%, 7.5%, 9.5%, and 11.5%, with the addition of 2% each of pyrogallol, copper (II) sulfate, and xanthan gum. Distilled water was used as the solvent. The dyeing process was conducted by immersing 200 strands of grey hair in preparation for 4 hours, followed by visual observation of colour changes. Colour stability was tested through 15 wash cycles and exposure to sunlight for 5 hours. An irritation test was also conducted on volunteers to evaluate the safety of the hair dye preparation. The study's results indicate that increasing the concentration of ethanol extract from jamblang bark affects the effectiveness of hair dyeing. The optimal formulation was achieved at a 7.5% extract concentration with the addition of 2% pyrogallol, 2% copper (II) sulfate, and 2% xanthan gum, which resulted in black colour. Stability tests showed that the colour remained unchanged after 15 wash cycles and 5 hours of sunlight exposure. Furthermore, the irritation test on volunteers demonstrated that the preparation did not cause skin irritation reactions. Thus, the ethanol extract of jamblang bark has the potential to serve as a safe natural hair dye, offering good colour stability and effectiveness in darkening grey hair.
Impacto Da Cirurgia de Revascularização de Emergência Em Pacientes Politraumatizados Com Lesão Cardíaca
Authors: Souza Jorge Augusto Soares de , FERREIRA FERNANDO VIEIRA , Fausto Patrícia Ferreira , Waughan Italo Rangel Soares , Mello Paula Rocha , Araújo Daniel Lucas Pinheiro de , Sobrinho Heráclio Durán Serra , Ferreira Samira Gonçalves , Júnior Gonzaga de Souza Gontijo , Araújo Vanessa Soares de , Oliveira Bruna Verena Elizeu de , Oliveira João Amado Santos de , MARTINS IGOR SIMÕES , Umpierre Luísa dos Santos , Ferreira José Henrique De Abreu
Published: February 2025

Este artigo tem como objetivo realizar uma revisão da literatura científica sobre a cirurgia de revascularização de emergência é um procedimento realizado para restaurar o fluxo sanguíneo em áreas do coração que estão comprometidas, muitas vezes em resultado de trauma, como em pacientes politraumatizados. Esses pacientes podem apresentar lesão cardíaca devido a contusões, lacerações ou isquemia relacionada ao trauma. os avanços no tratamento de politraumatizados, com ênfase nas intervenções cirúrgicas de emergência. Para isso, foram utilizados como motores de busca os indexadores PubMed, Scopus e Web of Science, com a utilização dos unitermos "Politraumatizados, Tratamento cirúrgico de emergência, Avanços, Manejo cirúrgico". A revisão revelou que, nos últimos anos, houve significativos avanços nas abordagens cirúrgicas para o manejo de politraumatizados, como a implementação de técnicas minimamente invasivas, o aprimoramento dos protocolos de atendimento precoce (como o ATLS) e o uso de tecnologias de imagem avançadas para diagnóstico e planejamento cirúrgico. Esses avanços proporcionam melhores resultados clínicos, redução de complicações pós−operatórias e recuperação mais rápida, com maior taxa de sobrevivência em comparação com os métodos tradicionais.
ANESTESIA EM CASOS DE PRÉ-ECLÂMPSIA E ECLÂMPSIA: PROTOCOLOS ATUALIZADOS
Authors: Jamesson Borralho Paes de Barros Filho  , Júlia Maria Cardoso da Silva  , Marcus Vinícius Stevanin de Souza  , Alan Alves da Conceição  , Elia Maria Floirian Matamoros  , Thomas Mendes Carvalho  , Thays Oliveira Maia de Araújo  , Luís Felipe Casara Filgueiras  , Vitória Ferreira Alves  , Thaís Melise Lopes Pina  , Ana Patrícia Santiago Protásio  , Erycles Rennan Martins Silva Freire
Published: February 2025

A pré-eclâmpsia e a eclâmpsia representam condições obstétricas graves que exigem manejo anestésico criterioso devido ao risco aumentado de complicações maternas e fetais. O controle hemodinâmico, a prevenção de convulsões e a garantia da segurança materno-fetal são prioridades durante a condução anestésica nesses casos. A escolha entre anestesia regional e geral deve levar em consideração fatores como estabilidade hemodinâmica, coagulopatia e presença de edema cerebral. Além disso, a administração adequada de antihipertensivos e a monitorização rigorosa do equilíbrio hemodinâmico são fundamentais para reduzir riscos intraoperatórios.Este artigo revisa os protocolos anestésicos atualizados para pacientes com pré-eclâmpsia e eclâmpsia, enfatizando a importância da escolha da técnica anestésica, do uso de agentes anestésicos específicos, do controle pressórico e do monitoramento perioperatório. Além disso, também são discutidas limitações nos estudos existentes e direções para futuras pesquisas, destacando a necessidade de estudos multicêntricos para aprimorar as diretrizes clínicas e padronizar condutas anestésicas baseadas em evidências.
Tratamento da Aterosclerose
Authors: BARROS DE MACEDO RYAN RAFAEL , AUGUSTO JESUS FIUZA YURI , CHOQUE FULGUERA VICTORIA DIANIRA , BARBOSA DUTRA PEDRO , DA SILVA KAUAN FERNANDO , GRASSO ISABELA VITÓRIA , SCHEFFER CASTELLER ELIAS , DE OLIVEIRA ALVES DIEGO ALESSANDRO , MEDEIROS SHEYLLA KARINE , PEREIRA DE OLIVEIRA GABRIEL , RAVEL LOPES ARRAIS MATHEUS , DE ANDRADE EDUARDO BARION
Published: February 2025

Os avanços recentes no uso de exossomos e nanotecnologia têm demonstrado grande potencial terapêutico no tratamento da aterosclerose. Exossomos derivados de diferentes tipos celulares, como células-tronco mesenquimais, células progenitoras endoteliais, macrófagos da medula óssea e plaquetas, desempenham um papel fundamental na modulação da inflamação, regulação da apoptose e promoção da reparação vascular. A presença de microRNAs específicos nesses exossomos influencia vias inflamatórias e oxidativas críticas, contribuindo para a estabilização da placa aterosclerótica e a redução da progressão da doença. Além disso, a nanotecnologia tem sido explorada como uma abordagem promissora para otimizar a entrega de fármacos e reduzir efeitos adversos sistêmicos. Estratégias inovadoras, como fototerapia e terapia sônica, também vêm sendo investigadas para complementar as terapias convencionais. Esses avanços representam uma revolução na abordagem da aterosclerose, oferecendo novas perspectivas terapêuticas para o manejo clínico da doença.