bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Some Biostimulants on the Vegetative Growth, Yield, Fruit Quality Attributes and Nutritional Status of Apple
Authors: Mosa Walid F. A. , Sas-Paszt Lidia , Głuszek Sławomir , Górnik Krzysztof , Anjum Muhammad Akbar , Saleh Abaidalah A. , Abada Hesham S. , Awad Rehab M.
Published: December 2022

Although the application of chemical fertilizers to crops promotes plant growth and yield, their continuous use affects soil heath and creates environmental pollution. On the other hand, plant biostimulants improve nutrients absorption, plant growth, yield and produce quality and are environment-friendly. Therefore, an experiment was conducted during 2021-22 to evaluate the effect of some biostimulants on the performance of the apple cv. Anna, planted in a sandy loam soil at Marsa Matruh governorate, Egypt. Ninety trees were randomly selected and sprayed with 4 or 6% moringa leaf extract (MLE), 0.3 or 0.4% seaweed extract (SWE), 1000 or 2000 mg L−1 Fulvic acid (FA), 4% MLE + 0.3% SWE + 1000 mg L−1 FA (combination 1), or 6% MLE + 0.4% SWE + 2000 mg L−1 FA (combination 2) before flowering, during full bloom and one month later and compared with a control (untreated trees). The results demonstrated that spraying MLE, SWE or FA or their combinations positively improved the vegetative growth, fruit set %, fruit yield and fruit physical and chemical characteristics as well as leaf nutritional status. The positive effect of MLE, SWE and FA was increased in parallel to an increase in the used concentration of each one of them. The highest increments in the measured parameters were accompanied by the application of combination 2 over the other treatments.
Reformulation of Top-Selling Processed and Ultra-Processed Foods and Beverages in the Peruvian Food Supply after Front-of-Package Warning Label Policy
Authors: Saavedra-Garcia Lorena , Meza-Hernández Mayra , Diez-Canseco Francisco , Taillie Lindsey Smith
Published: December 2022

Front-of-package warning label (FOPWL) policies incentivize the food industry to reduce the content of regulated nutrients in products. We explored changes in the content of nutrients of concern (sugar, saturated fat, trans fat, and sodium) and the percentage of products in the Peruvian food supply that would carry a FOPWL before and after Peru’s implementation of FOPWLs. Longitudinal data on the top-selling foods and beverages (n = 94) were collected at three time points: three months before the implementation of the policy, four months after, and two years after. Using the nutritional information declared on products’ labels, we compared quantities of nutrients of concern and the percentage of foods that would carry a FOPWL at each time point. Between the first and the third data collection, a decrease in the median sugar content of beverages was observed (from 9.0 to 5.9 g/100 mL, p = 0.005), accompanied by an increase in the use of nonnutritive sweeteners. This change drove the reduction of the percentage of beverages that would carry a FOPWL (from 59 to 31%, p = 0.011). Among foods, decreases were observed in saturated fat (from 6.7 to 5.9 g/100 g, p = 0.002). The percentage of foods that would carry a FOPWL according to their nutritional profile declined from before to after implementation of the policy (from 82 to 62%, p < 0.001). The study shows that the industry reformulated products in Peru after implementation of its FOPWL policy.
Competence Development and Collaborative Climate as Antecedents of Job Performance, Job Commitment and Uncertainty: Validation of a Theoretical Model across Four Hospitals
Authors: Jensen Maria Therese , Øygarden Olaug , Mikkelsen Aslaug , Olsen Espen
Published: December 2022

Knowledge is lacking regarding how organizational factors are associated with uncertainty in patient treatment. Thus, the aim of the current study was to investigate how competence development and collaborative climate relates to job performance and job commitment, and further whether job performance and job commitment relate to uncertainty. Additionally, we examined whether these associations differed between four different hospitals. We applied data from 6445 hospital workers who provided care to patients. Basic statistics and structural equation modelling (SEM) were used to test the validity of the theoretical model developed in the study and the hypothesized associations. All hypothesized paths between the latent variables were significant and in accordance with the model across the four hospitals. The current study has implications for practical human resource management and indicates that competence development should be strengthened at the individual level and collaborative climate should be strengthened at the ward level. Strengthening competence development and collaborative climate can increase job performance and job commitment of individual workers and reduce uncertainty during care in hospital settings.
Loss of Muscle Mass and Vulnerability in Institutionalized Older Adults
Authors: Araújo Mayara Priscilla Dantas , Nobre Thaiza Teixeira Xavier , Rosendo Clara Wilma Fernandes , Lima Flávio Anselmo Silva de , Nunes Vilani Medeiros de Araújo , Torres Gilson de Vasconcelos
Published: December 2022

This study aimed to evaluate the association between muscle mass and vulnerability in institutionalized older adults. A cross-sectional study was carried out in eight philanthropic Long-Term Care Facilities (LTCF) located in the metropolitan area of Natal, Rio Grande do Norte, Brazil. The participants were individuals aged 60 years or older who were present in the institutions at the time of data collection. To assess muscle mass, the calf circumference was categorized into loss of muscle mass (<31 cm) and preserved muscle mass (≥31 cm). The vulnerability was assessed by The Vulnerable Elders Survey (VES-13). Of the 250 older adults evaluated, 46.1% presented loss of muscle mass, which was associated with the presence of physical limitation, vulnerability, and age group (p < 0.05). The presence of vulnerability was the main factor contributing to loss of muscle mass (R2 = 8.8%; B = 0.781; 95% CI 0.690–0.884; p < 0.001). Loss of muscle mass is associated with disability in institutionalized older adults.
The Impact of Mothers’ Perceived Unsupportive Intergenerational Co-Parenting on Children’s Social Competence: Evidence from China
Authors: Xu Xinpei , Song Lihong , Li Xiaoyun , Li Yan
Published: December 2022

This study examined whether parenting styles mediated the relationship between unsupportive intergenerational co-parenting and children’s social competence, and whether the first stage of the mediating process, as well as the direct association between unsupportive intergenerational co-parenting and children’s social competence, was moderated by maternal psychological flexibility. The theoretical model was tested using data collected from 412 mothers of children aged 3–6 years at four kindergartens in Shanghai, China. The results showed that: (1) unsupportive intergenerational co-parenting was negatively associated with children’s social competence through decreased maternal authoritative parenting and increased authoritarian parenting and (2) the first stage of the mediation mechanism was moderated by maternal psychological flexibility. Specifically, unsupportive intergenerational co-parenting was significantly associated with authoritative and authoritarian parenting for mothers with low and high psychological flexibility, respectively, and the magnitude of the association was higher for mothers with low psychological flexibility. These findings extend the understanding of how and when unsupportive intergenerational co-parenting impacts children’s social competence.
Proposed Cut-Off Score for the Japanese Version of the Fear of Coronavirus Disease 2019 Scale (FCV-19S): Evidence from a Large-Scale National Survey in Japan
Authors: Midorikawa Haruhiko , Tachikawa Hirokazu , Aiba Miyuki , Shiratori Yuki , Sugawara Daichi , Kawakami Naoaki , Okubo Ryo , Tabuchi Takahiro
Published: December 2022

The Fear of coronavirus disease 2019 (COVID-19) Scale (FCV-19S) is a seven-item self-administered psychological scale for measuring the fear of this disease. The scale has been widely adapted and validated worldwide. This study aimed to propose a cut-off score for the validated Japanese version of the FCV-19S. We conducted a nationwide online survey and included 26,286 respondents in the analysis. Respondents answered questions on their sociodemographic characteristics, and using the FCV-19S and six-item Kessler Psychological Distress Scale, we measured psychological distress and assessed whether the fear of COVID-19 interfered with their daily lives. A total score of ≥21 points was considered adequate to identify those with psychological distress or difficulties in daily living because of the fear of COVID-19. This cut-off score will contribute to mental health assessment during the COVID-19 pandemic.
Coupling and Coordinating Relationship between Agricultural Eco-Efficiency and Food Security System in China
Authors: Wang Ruixue , Chen Jiancheng , Li Minhuan
Published: December 2022

Carbon peaking, carbon neutrality goals and food security are the basis of sustainable development, and exploring the coordination relationship between China’s agricultural eco-efficiency and food security system has a major significance for the implementation of relevant strategies. This paper is based on collaboration research on the synergistic relationship between agricultural eco-efficiency and food security systems using methods such as entropy weight method, coupling coordination model, spatial autocorrelation model, etc., revealing the evolution-driven mechanism of the coupling coordination degree. This study found that a higher level of coupling coordination always occurs in those areas with high standard farmland construction and large grain production scale, while economically developed areas appear to have a lower overall coordination level limited by endowment constraints and division of labor in development planning. It shows a positive spatial correlation in terms of geographical distance between agricultural eco-efficiency and food security, and the positive spillover effect gradually increases but is not strong overall. China should combine regional resource endowment and development planning, pay attention to the improvement of large-scale and standardized agricultural production, continue to strengthen the development of clean agricultural production, and achieve food security under the constraints of the carbon peaking and carbon neutrality goals.
Health Risk Assessment for Human Exposure to Heavy Metals via Food Consumption in Inhabitants of Middle Basin of the Atrato River in the Colombian Pacific
Authors: Caicedo-Rivas Gabriel , Salas-Moreno Manuel , Marrugo-Negrete José
Published: December 2022

The Atrato river basin is one of the world’s most biodiverse areas; however, it is highly impacted by mercury gold mining, which generates air, water, and soil pollution. (1) Background: The concentrations of persistent heavy metal pollutants, mercury (Hg), lead (Pb), cadmium (Cd), and arsenic (As) in the fish, fruits, and vegetables most consumed by the riverside inhabitants of the middle basin of the Atrato river represent a danger to public health; (2) Methods: A total of 154 samples of different fruits and vegetables and 440 samples of fish were analyzed by atomic absorption spectroscopy. A sample of 446 people were surveyed to evaluate food consumption and carcinogenic and non-carcinogenic risk; (4) Conclusions: High concentrations of As, Hg, Pb, and Cd were identified in fish, fruits-tubers, and vegetables-stems commonly consumed by inhabitants of the middle basin of the Atrato River, which exceeded the Codex limits and the limits established by the WHO/FAO, especially for carnivorous fish species. A high carcinogenic and non-carcinogenic risk was evidenced amongst inhabitants of the middle basin of the Atrato River due to the consumption of fish contaminated with high concentrations of As, MeHg, and THg. The risk due to the consumption of vegetables was very low.
Impact of Two Whole-Body Vibration Exercise Protocols on Body Composition of Patients with Metabolic Syndrome: A Randomized Controlled Trial
Authors: Reis-Silva Aline , Coelho-Oliveira Ana C. , Martins-Anjos Elzi , Moura-Fernandes Márcia Cristina , Mulder Alessandra , Xavier Vinicius Layter , Mendonça Vanessa A. , Lacerda Ana C. R. , Paineiras-Domingos Laisa Liane , Taiar Redha , Sartorio Alessandro , Bernardo-Filho Mario , Sá-Caputo Danúbia C.
Published: December 2022

(1) Background: This study investigated the effects of two 6-week whole-body vibration exercise (WBVE) protocols on body composition in patients with metabolic syndrome (MSy). Thirty-three patients were allocated to either the Fixed Frequency WBVE Group (FFG-WBVE) or the Variable Frequency WBVE Group (VFG-WBVE). (2) Methods: A side-alternating vibration platform was used and the patients remained in the semi-squat position on this platform. In the FFG-WBVE (n = 12; median age = 50.50 years) and (body mass index BMI = 31.95 kg/m2), patients were exposed to 10 s of mechanical vibration at a fixed frequency of 5 Hz, followed by 50 s without vibration. In the VFG-WBVE (n = 10; median age = 57.50 years) and (BMI = 32.50 kg/m2), the patients performed 60 s of mechanical vibration at different frequencies from 5 to 16 Hz). Body composition evaluated through (bioelectrical impedance analysis and anthropometric measurements) were was evaluated before and after the all the interventions in each group. (3) Results: The VFG-WBVE decreased waist circumference, p = 0.01 and segmental fat mass [left arm, p = 0.01; right arm, p = 0.02 and trunk, p = 0.03]. Bone content increased, p = 0.01. No significant changes were observed in the FFG- WBVE. (4) Conclusions: In conclusion, this study demonstrated that 6 weeks of WBVE with a protocol with variable frequency can positively modify the body composition of MSY patients. These findings might contribute to improvements in the metabolic health of these patients.
Study on Chinese Farmland Ecosystem Service Value Transfer Based on Meta Analysis
Authors: Nie Liangzhen , Cai Bifan , Luo Yixin , Li Yue , Xie Neng , Zhang Tong , Yang Zhenlin , Lin Peixin , Ma Junshan
Published: December 2022

An analytic database was built based on meta-regression analysis (MRA) method, mainly including ecosystem service type, farmland division, cultivated land type, value assessment method, and farmland characteristics. The feasible weighted least square (FWLS) method was adopted to comprehensively investigate the seventy observations from empirical studies. The results indicate that: (1) except the negative impact of farmland area on farmland value, such factors as paddy field, good soil conservation function, mainly providing agricultural products, and using market value method for assessment all produce positive effect on the promotion of farmland value. (2) In meta-regression analysis, the average transfer error is 36.74%, and the median transfer error is 14.59%. (3) Under the A1B, A2, B1, and B2 scenarios of IPCC SRES, it is discovered from calculation that the value changes under different scenarios have some differences, in which, the total value rises significantly under A2 scenario and will reach to 15,220 billion yuan until the year of 2100; while the total value loss is the greatest under B1 scenario and will fall to 6320 billion yuan until the year of 2100. Finally, this paper gives some suggestions for scholars to deeply study the service value of farmland ecosystem as well as for the government to formulate differentiation policies.
Types of Resident and Price Distribution in Urban Areas: An Empirical Investigation in China Mainland
Authors: Chen Kaida , Lin Hanliang , Cao Fangxiao , Li Xin , You Shuying , Zhang Qian
Published: December 2022

Finding an ideal residence in the city is a common and long-lasting topic for city residents. Therefore, understanding the value composition of urban residences and consumer preference can assist other future consumers in purchasing the appropriate residence in the appropriate urban location. Similarity, this information is helpful to municipal government planners in determining the use of urban land, to real estate developers in choosing where to develop commercial residences, and to the relevant research community in determining the effects of changes on the use of urban land. Although the study on housing prices influencing variables has long attracted scholarly attention, there has been limited research on the types of residences and developers, so it is essential to expand the research on this subject. In the study, Fuzhou, China, serves as the research context. The study employs econometrics to investigate the impact of residence and developer types on housing prices. Based on the study, it is shown that the price of commercial residences can vary depending on the types of residences and developers. The study also revealed that different types of residences and developers are subject to distinct levels of price regulation. In addition, it is found that different housing price impact variables have varying degrees of impact on different types of commercial residences and developers.
Mechanism and Influencing Factors of Low-Carbon Coal Power Transition under China’s Carbon Trading Scheme: An Evolutionary Game Analysis
Authors: Liu Feng , Wei Yihang , Du Yu , Lv Tao
Published: December 2022

To avoid the energy supply risk caused by the large-scale integration of renewable power with the grid, coal power plants with carbon capture utilization and storage (CCUS) have the potential to play an important role in the transition to a low-carbon electricity system. Based on evolutionary game theory, this study analyzed the equilibrium states, evolutionary trajectory and the corresponding critical conditions between the government and the coal power enterprises in this process. Subsequently, a numerical analysis was conducted. The results showed that the carbon trading scheme can directly promote the upgrade of coal power and this effect can be enhanced by establishing the market-oriented trading mechanism of electricity. The slack quota policy at the current stage can contribute to the emergence of the forerunners adopting the CCUS. The technical level of the CCUS had the most significant influence on the equilibrium of the game system. As technology advances, the game system can rapidly achieve the ideal stable strategy (of non-intervention, low-carbon upgrade). On this basis, the government should promote the synergetic development of the carbon market and power market. Additionally, more financial subsidies should be shifted to R&D (research and development) investment.
Association between Motivation in Physical Education and Positive Body Image: Mediating and Moderating Effects of Physical Activity Habits
Authors: Jankauskiene Rasa , Urmanavicius Danielius , Baceviciene Migle
Published: December 2022

Concerns about body image might prevent adolescents from participating in physical education (PE) classes and physical activities during leisure-time. In this cross-sectional study, we assessed the relationships between teacher support of autonomy, student motivations for PE, and positive body image, in a sample of Lithuanian adolescents. A total of 715 adolescents (51.89% girls) participated in the study. Ages ranged from 14 to 18 years, with a mean age of 16.00 (SD = 0.79) for girls and 15.99 (SD = 0.75) for boys. The questionnaire consisted of demographic questions, the Learning Climate Questionnaire, the Revised Perceived Locus of Causality in Physical Education Questionnaire, the Body Appreciation Scale-2, the Self-Report Habit Index for Physical Activity (PA), perceived physical fitness (PPF), and Godin Leisure-Time Exercise Questionnaire. The results showed that teacher support for students’ autonomy was associated with higher positive body image. In adolescent girls, autonomous motivation for PE was the mediator between teacher support of autonomy and positive body image. The associations between self-determined motivation in PE and positive body image were mediated by PPF on one hand, and through PA habits and PPF on the other hand of the structural equation model (in girls). PA habits moderated associations between PE motivation and PPF. Associations between PE motivation and PPF were stronger in girls with the lowest PA habits compared to girls with mean PA habits. These results suggest that PE classes are important for promoting students’ positive body images. PE teachers are advised to use pedagogical strategies that promote the self-determined motivation of students for PE. Increased self-determined motivation for physical education might be an effective strategy for physical self-perception and positive body image promotion in adolescent girls, especially those with low PA habits.
Community Resilience and COVID-19: A Fuzzy-Set Qualitative Comparative Analysis of Resilience Attributes in 16 Countries
Authors: Yi Fangxin , Woo Jun Jie , Zhang Qiang
Published: December 2022

The COVID-19 pandemic has caused massive disruptions to governments and societies across the world. While public healthcare systems have come under immense pressure, public trust in governments and institutions are also in decline. In this paper, we seek to assess the resilience of policy systems and processes in 16 countries during the COVID-19 pandemic through the use of fuzzy-set Qualitative Comparative Analysis (fsQCA). We focus specifically on robustness, preparedness, social capital, and institutional strength as key attributes of community resilience at city-level. Our analysis of the data reveals that COVID-19 resilience is dependent on a combination of factors, with a multi-factorial approach to policy design and governance necessary for effective pandemic and disaster recovery.
Testing the Multiple Disadvantage Model of Health with Ethnic Asian Children: A Secondary Data Analysis
Authors: Cheng Tyrone C. , Lo Celia C.
Published: December 2022

This study of ethnic Asian children in the United States asked whether their health exhibited relationship with any of six factors: social disorganization, social structural factors, social relationships, the health of their parents, their access to medical insurance, acculturation. The sample of 1350 ethnic Asian children was extracted from the 2018 National Survey of Children’s Health. Logistic regression results showed that these children’s excellent/very good/good health was associated positively with safe neighborhoods, family incomes, family cohesiveness, family support, and receipt of Temporary Assistance for Needy Families (TANF). In turn, health was associated negatively with single-mother households. Implications of the present results in terms of interventions promoting family support, TANF participation, safe neighborhoods, and professionals’ cultural competency are discussed.
The Effect of Left-Behind Women on Fertilizer Use: Evidence from China’s Rural Households Engaging in Rural-Urban Migration
Authors: Tang Kai
Published: December 2022

Rural-urban migration in developing countries has required left-behind women to assume the role of key decision makers and take increasing responsibility for agricultural production. However, little is known about the effect of rural-urban migration on fertilizer use when left-behind women assume key decision-maker roles. This study highlights the effect of left-behind women on fertilizer use, drawing on nationwide household survey data in China. The results indicate that households with recognized left-behind women heads use less fertilizer than those with recognized men heads, while households with de facto left-behind women heads use more fertilizer. Moreover, the average nexus between households with recognized left-behind women heads whose major agricultural income comes from grain crops and fertilize use is negative but small in size and statistically insignificant. The findings indicate that future policy efforts aimed at decreasing rural environmental degradation should place greater emphasis on left-behind women’s empowerment in socioeconomic decision-making within and outside the household, thereby contributing to an environment in which left-behind women farmers can succeed in a sustainable way.
What Is the Role of Psychological Factors in Long COVID Syndrome? Latent Class Analysis in a Sample of Patients Recovered from COVID-19
Authors: Craparo Giuseppe , La Rosa Valentina , Commodari Elena , Marino Graziella , Vezzoli Michela , Faraci Palmira , Vicario Carmelo , Cinà Gabriella , Colombi Morena , Arcoleo Giuseppe , Severino Maria , Costanzo Giulia , Gori Alessio , Mangiapane Ernesto
Published: December 2022

Background: This study aimed to identify clusters of long COVID-19 symptoms using latent class analysis and investigate the psychological factors involved in the onset of this syndrome. Method: Five hundred and six subjects recovering from COVID-19 completed a series of standardized questionnaires to evaluate the personality traits, alexithymia, and post-traumatic stress. Results: Five classes were identified: Brain fog (31.82%), No symptoms (20.95%), Sensory disorders (18.77%), Breath impairment (17.59%), and Multiple disorders (10.87%). Women reported post-COVID-19 respiratory symptoms and multiple disorders to a greater extent than men. Hospitalized subjects were more likely to report persistent symptoms after COVID-19 than asymptomatic or home-treated subjects. Antagonism, hyperarousal, and difficulty identifying emotions significantly predicted post COVID-19 symptoms. Conclusions: These findings open new questions for research on long COVID-19 and how states of emotional dysregulation can alter the physiological processes of the body and contribute to the onset of organic pathologies.
Correlation of Road Network Structure and Urban Mobility Intensity: An Exploratory Study Using Geo-Tagged Tweets
Authors: Geng Li , Zhang Ke
Published: December 2022

Urban planners have been long interested in understanding how urban structure and activities are mutually influenced. Human mobility and economic activities naturally drive the formation of road network structure and the accessibility of the latter shapes the patterns of movement flow across urban space. In this paper, we perform an exploratory study on the relationship between the street network structure and the intensity of human movement in urban areas. We focus on two cities and we utilize a dataset of geo-tagged tweets that can form a proxy to urban mobility and the corresponding street networks as obtained from OpenStreetMap. We apply three network centrality measures, including closeness, betweenness and straightness centrality, calculated at a global or local scale, as well as under mixed or individual transportation mode (e.g., driving, biking and walking) with its directional accessibility, to uncover the structural properties of urban street networks. We further design an urban area transition network and apply PageRank to capture the intensity of human mobility. Our correlation analysis indicates different centrality metrics have different levels of correlation with the intensity of human movement. The closeness centrality consistently shows the highest correlation (with a coefficient around 0.6) with human movement intensity when calculated at a global scale, while straightness centrality often shows no correlation at the global scale or weaker correlation ρ≈0.4 at the local scale. The correlation levels further depend on the type of directional accessibility and of various types of transportation modes. Hence, the directionality and transportation mode, largely ignored in the analysis of road networks, are crucial. Furthermore, the strength of the correlation varies in the two cities examined, indicating potential differences in urban spatial structure and human mobility patterns.
VANL-100 Attenuates Beta-Amyloid-Induced Toxicity in SH-SY5Y Cells
Authors: Collins Andrila E. , Saleh Tarek M. , Kalisch Bettina E.
Published: December 2022

Antioxidants are being explored as novel therapeutics for the treatment of neurodegenerative diseases such as Alzheimer’s disease (AD) through strategies such as chemically linking antioxidants to synthesize novel co-drugs. The main objective of this study was to assess the cytoprotective effects of the novel antioxidant compound VANL-100 in a cellular model of beta-amyloid (Aβ)-induced toxicity. The cytotoxic effects of Aβ in the presence and absence of all antioxidant compounds were measured using the 3-(4,5-dimethylthiazol-2-yl)2-5-diphenyl-2H-tetrazolium bromide (MTT) assay in SH-SY5Y cells in both pre-treatment and co-treatment experiments. In pre-treatment experiments, VANL-100, or one of its parent compounds, naringenin (NAR), alpha-lipoic acid (ALA), or naringenin + alpha-lipoic acid (NAR + ALA), was administrated 24 h prior to an additional 24-h incubation with 20 μM non-fibril or fibril Aβ25–35. Co-treatment experiments consisted of simultaneous treatment with Aβ and antioxidants. Pre-treatment and co-treatment with VANL-100 significantly attenuated Aβ-induced cell death. There were no significant differences between the protective effects of VANL-100, NAR, ALA, and NAR + ALA with either form of Aβ, or in the effect of VANL-100 between 24-h pre-treatment and co-treatment. These results demonstrate that the novel co-drug VANL-100 is capable of eliciting cytoprotective effects against Aβ-induced toxicity.
Membrane Proteins: Structure, Function and Motion
Authors: Jelokhani-Niaraki Masoud
Published: December 2022

Cell membranes are intricate multicomponent supramolecular structures, with a complex variable morphology and chemical composition [...]
Therapeutic Perspectives of HIV-Associated Chemokine Receptor (CCR5 and CXCR4) Antagonists in Carcinomas
Authors: González-Arriagada Wilfredo Alejandro , García Isaac E. , Martínez-Flores René , Morales-Pison Sebastián , Coletta Ricardo D.
Published: December 2022

The interaction between malignant cells and the tumor microenvironment is critical for tumor progression, and the chemokine ligand/receptor axes play a crucial role in this process. The CXCR4/CXCL12 and CCR5/CCL5 axes, both related to HIV, have been associated with the early (epithelial–mesenchymal transition and invasion) and late events (migration and metastasis) of cancer progression. In addition, these axes can also modulate the immune response against tumors. Thus, antagonists against the receptors of these axes have been proposed in cancer therapy. Although preclinical studies have shown promising results, clinical trials are needed to include these drugs in the oncological treatment protocols. New alternatives for these antagonists, such as dual CXCR4/CCR5 antagonists or combined therapy in association with immunotherapy, need to be studied in cancer therapy.
Forward Hand Gesture Spotting and Prediction Using HMM-DNN Model
Authors: Elmezain Mahmoud , Alwateer Majed M. , El-Agamy Rasha , Atlam Elsayed , Ibrahim Hani M.
Published: December 2022

Automatic key gesture detection and recognition are difficult tasks in Human–Computer Interaction due to the need to spot the start and the end points of the gesture of interest. By integrating Hidden Markov Models (HMMs) and Deep Neural Networks (DNNs), the present research provides an autonomous technique that carries out hand gesture spotting and prediction simultaneously with no time delay. An HMM can be used to extract features, spot the meaning of gestures using a forward spotting mechanism with varying sliding window sizes, and then employ Deep Neural Networks to perform the recognition process. Therefore, a stochastic strategy for creating a non-gesture model using HMMs with no training data is suggested to accurately spot meaningful number gestures (0–9). The non-gesture model provides a confidence measure, which is utilized as an adaptive threshold to determine where meaningful gestures begin and stop in the input video stream. Furthermore, DNNs are extremely efficient and perform exceptionally well when it comes to real-time object detection. According to experimental results, the proposed method can successfully spot and predict significant motions with a reliability of 94.70%.
Synthesis of K+ and Na+ Synthetic Sodalite Phases by Low-Temperature Alkali Fusion of Kaolinite for Effective Remediation of Phosphate Ions: The Impact of the Alkali Ions and Realistic Studies
Authors: Bellucci Stefano , Eid Mohamed Hamdy , Fekete Ilona , Péter Szűcs , Kovács Attila , Othman Sarah I. , Ajarem Jamaan S. , Allam Ahmed A. , Abukhadra Mostafa R.
Published: December 2022

Two sodalite phases (potassium sodalite (K.SD) and sodium sodalite (Na.SD)) were prepared using alkali fusion of kaolinite followed by a hydrothermal treatment step for 4 h at 90 °C. The synthetic phases were characterized as potential adsorbents for PO43− from the aqueous solutions and real water from the Rákos stream (0.52 mg/L) taking into consideration the impact of the structural alkali ions (K+ and Na+). The synthetic Na.SD phase exhibited enhanced surface area (232.4 m2/g) and ion-exchange capacity (126.4 meq/100 g) as compared to the K.SD phase. Moreover, the Na.SD phase exhibited higher PO43− sequestration capacity (Qmax = 261.6 mg g−1 and Qsat = 175.3 mg g−1) than K.SD phase (Qmax = 201.9 mg g−1 and Qsat = 127.4 mg g−1). The PO43− sequestration processes of both Na.SD and K.SD are spontaneous, homogenous, and exothermic reactions that follow the Langmuir isotherm and pseudo-first-order kinetics. Estimation of the occupied active site density validates the enrichment of the Na.SD phase with high quantities of active sites (Nm = 86.1 mg g−1) as compared to K.SD particles (Nm = 44.4 mg g−1). Moreover, the sequestration and Gaussian energies validate the cooperation of physisorption and weak chemisorption processes including zeolitic ion exchange reactions. Both Na.SD and K.SD exhibit significant selectivity for PO43− in the coexisting of other common anions (Cl−, SO42−, HCO3−, and NO3−) and strong stability properties. Their realistic application results in the complete adsorption of PO43- from Rákos stream water after 20 min (Na. SD) and 60 min (K.SD).
Improved VO2max Estimation by Combining a Multiple Regression Model and Linear Extrapolation Method
Authors: Matsuo Tomoaki , So Rina , Murai Fumiko
Published: December 2022

Maximal oxygen consumption (VO2max) is an important health indicator that is often estimated using a multiple regression model (MRM) or linear extrapolation method (LEM) with the heart rate (HR) during a step test. Nonetheless, both methods have inherent problems. This study investigated a VO2max estimation method that mitigates the weaknesses of these two methods. A total of 128 adults completed anthropometric measurements, a physical activity questionnaire, a step test with HR measurements, and a VO2max treadmill test. The MRM included step-test HR, age, sex, body mass index, and questionnaire scores, whereas the LEM included step-test HR, predetermined constant VO2 values, and age-predicted maximal HR. Systematic differences between estimated and measured VO2max values were detected using Bland–Altman plots. The standard errors of the estimates of the MRM and LEM were 4.15 and 5.08 mL·kg−1·min−1, respectively. The range of 95% limits of agreement for the LEM was wider than that for the MRM. Fixed biases were not significant for both methods, and a significant proportional bias was observed only in the MRM. MRM bias was eliminated using the LEM application when the MRM-estimated VO2max was ≥45 mL·kg−1·min−1. In conclusion, substantial proportional bias in the MRM may be mitigated using the LEM within a limited range.
Long-Term Survival after Extended Sleeve Lobectomy (ESL) for Central Non-Small Cell Lung Cancer (NSCLC): A Meta-Analysis with Reconstructed Time-to-Event Data
Authors: Magouliotis Dimitrios , Zotos Prokopis-Andreas , Karamolegkou Anna , Tatsios Evangelos , Spiliopoulos Kyriakos , Athanasiou Thanos
Published: December 2022

Objective: We conducted a thorough literature search on patients with central non-small cell lung cancer (NSCLC) undergoing either extended sleeve lobectomy (ESL) or pneumonectomy (PN). Methods: We identified all original research studies that compared the long-term survival of ESL versus PN from 1990 to 2022. The primary endpoints were the median overall survival (OS) and disease-free survival (DFS). Complications, operative mortality, and the reoperation rate were the secondary endpoints. Regarding the primary endpoints, independent patient data were extracted from the included studies, and pooled Kaplan–Meier curves were constructed. A sensitivity analysis was performed using the leave-one-out method. Results: Nine studies were included in the qualitative and seven in the quantitative synthesis, including 431 patients. Patients in the ESL group demonstrated a significantly higher OS compared with the PN group (HR, 0.63; 95% CI, 0.46–0.87; p = 0.005). In addition, patients undergoing ESL presented a significantly higher DFS compared to the PN group (HR, 0.57; 95% CI, 0.40–0.80; p = 0.004). These findings were further validated with a sensitivity analysis. The most common complications in the ESL group were bronchopleural fistula (4.6%), stricture (3.1%), prolonged air leakage (7.3%), sputum retention (4.6%), pneumonia (7.7%), and pulmonary vein thrombosis (1.5%). ESL was associated with a low reoperation rate (1.5%) and operative mortality (1.2%). Conclusions: The present meta-analysis indicates that ESL is associated with enhanced survival outcomes compared to PN for patients with central NSCLC. Further randomized controlled trials are necessary to validate our findings.
Development and External Validation of the STRATified CANcer Surveillance (STRATCANS) Multivariable Model for Predicting Progression in Men with Newly Diagnosed Prostate Cancer Starting Active Surveillance
Authors: Light Alexander , Lophatananon Artitaya , Keates Alexandra , Thankappannair Vineetha , Barrett Tristan , Dominguez-Escrig Jose , Rubio-Briones Jose , Benheddi Toufik , Olivier Jonathan , Villers Arnauld , Babureddy Kirthana , Abdelmoteleb Haitham , Gnanapragasam Vincent J.
Published: December 2022

For men with newly diagnosed prostate cancer, we aimed to develop and validate a model to predict the risk of progression on active surveillance (AS), which could inform more personalised AS strategies. In total, 883 men from 3 European centres were used for model development and internal validation, and 151 men from a fourth European centre were used for external validation. Men with Cambridge Prognostic Group (CPG) 1–2 disease at diagnosis were eligible. The endpoint was progression to the composite endpoint of CPG3 disease or worse (≥CPG3). Model performance at 4 years was evaluated through discrimination (C-index), calibration plots, and decision curve analysis. The final multivariable model incorporated prostate-specific antigen (PSA), Grade Group, magnetic resonance imaging (MRI) score (Prostate Imaging Reporting & Data System (PI-RADS) or Likert), and prostate volume. Calibration and discrimination were good in both internal validation (C-index 0.742, 95% CI 0.694–0.793) and external validation (C-index 0.845, 95% CI 0.712–0.958). In decision curve analysis, the model offered net benefit compared to a ‘follow-all’ strategy at risk thresholds of ≥0.08 and ≥0.04 in development and external validation, respectively. In conclusion, our model demonstrated good accuracy and clinical utility in predicting the progression on AS at 4 years post-diagnosis. Men with lower risk predictions could subsequently be offered less-intense surveillance. Further external validation in larger cohorts is now required.
Elevated Circulating Lactate Levels and Widespread Expression of Its Cognate Receptor, Hydroxycarboxylic Acid Receptor 1 (HCAR1), in Ovarian Cancer
Authors: Kerslake Rachel , Panfilov Suzana , Mustafa Nashrah , Hall Marcia , Kyrou Ioannis , Randeva Harpal S. , Karteris Emmanouil , Godfrey Richard
Published: December 2022

Background: Augmented glycolysis in cancer cells is a process required for growth and development. The Warburg effect provides evidence of increased glycolysis and lactic acid fermentation in cancer cells. The lactate end-product of glycolysis is receiving growing traction for its role as a cell signalling molecule. Ovarian cancer (OvCa) is also characterised by altered glucose metabolism. We aim to explore circulating lactate levels in patients with high-grade serous OvCa (HGSOC) and to elucidate the expression of the lactate receptor hydroxycarboxylic acid receptor 1 (HCAR1) in OvCa. Methods: HCAR1 expression was detected in patient biopsy cores using immunohistochemistry, while lactate was measured from whole blood with a Biosen-C line clinic measuring system. Results: We noted significantly elevated lactate levels in OvCa patients (4.3 ± 1.9 mmol/L) compared with healthy controls (1.4 ± 0.6 mmol/L; p < 0.0001), with an AUC of 0.96. The HCAR1 gene is overexpressed in OvCa compared to healthy controls (p < 0.001). Using an OvCa tissue microarray (>75% expression in 100 patients), high protein expression was also recorded across all epithelial OvCa subtypes and ovarian normal adjacent tissue (NAT). Conclusions: Lactate monitoring is a simple, cost-efficient test that can offer point-of-care results. Our data suggest that the potential of circulating lactate as a screening biomarker in OvCa merits further research attention.
An Investigation of the Association between 3D Spinal Alignment and Fibromyalgia
Authors: Ahbouch Amal , Moustafa Ibrahim M. , Shousha Tamer , Arumugam Ashokan , Oakley Paul , Harrison Deed E.
Published: December 2022

Fibromyalgia syndrome (FMS) is a common condition lacking strong diagnostic criteria; these criteria continue to evolve as more and more studies are performed to explore it. This investigation sought to identify whether participants with FMS have more frequent and larger postural/spinal displacements in comparison to a matched control group without the condition of FMS. A total of 67 adults (55 females) out of 380 participants with FMS were recruited. Participants with FMS were sex- and age-matched with 67 asymptomatic participants (controls) without FMS. We used a three-dimensional (3D) postural assessment device (Formetric system) to analyze five posture variables in each participant in both groups: (1) thoracic kyphotic angle, (2) trunk imbalance, (3) trunk inclination, (4) lumbar lordotic angle, and (5) vertebral rotation. In order to determine whether 3D postural measures could predict the likelihood of a participant having FMS, we applied the matched-pairs binary logistic regression analysis. The 3D posture measures identified statistically and clinically significant differences between the FMS and control groups for each of the five posture variables measured (p < 0.001). For three out of five posture measurements assessed, the binary logistic regression identified there was an increased probability of having FMS with an increased: (1) thoracic kyphotic angle proportional odds ratio [Prop OR] = 1.76 (95% CI = 1.03, 3.02); (2) sagittal imbalance Prop OR = 1.54 (95% CI = 0.973, 2.459); and (3) surface rotation Prop OR = 7.9 (95% CI = 1.494, 41.97). We identified no significant probability of having FMS for the following two postural measurements: (1) coronal balance (p = 0.50) and (2) lumbar lordotic angle (p = 0.10). Our study’s findings suggest there is a strong relationship between 3D spinal misalignment and the diagnosis of FMS. In fact, our results support that thoracic kyphotic angle, sagittal imbalance, and surface rotation are predictors of having FMS.
Discrepancy between the Status Quo and Adjusted Risk of First-Onset Suicidal Ideation in Older Adults: A Longitudinal Study Based on the Korean Welfare Panel Study (2011–2021)
Authors: Cho Youngdae , Jang Suk-Yong , Park Eun-Cheol , Bak Jean Kyung
Published: December 2022

Whether older adults can more likely commit suicide than those in other age groups, after adjusting for other possible causes, remains unknown. We aimed to examine why elderly individuals are more likely to develop first-onset suicidal ideation than individuals in other age groups. We identified 2018 young, 3329 middle-aged, and 2714 elderly individuals without a history of suicidal ideation, from the Korean Welfare Panel Study 2011–2021. To determine key stressors that can induce suicidal ideation, selected groups of variables were adjusted progressively in a generalized estimating equation (GEE) model. Incidence rates of the elderly, middle-aged, and young individuals were 15.9, 22.0, and 11.3 per 1000 person-years, respectively. In GEE analysis, a positive association was not noted between age group and suicidal ideation after adjusting for stressor variables. Furthermore, the overly adjusted model (Full model) showed a strong negative association with aging; young [odds ratio (OR): 1.68, 95% confidence interval (CI): 1.35–2.11] and middle-aged (OR: 1.94, 95% CI: 1.38–2.73) individuals were more likely to develop first-onset suicidal ideation than the elderly. We found that full models, particularly assessing wealth rather than income, can explain why the elderly have higher suicide rates than those in other age groups.
Molecular Diagnosis of Hypertrophic Cardiomyopathy (HCM): In the Heart of Cardiac Disease
Authors: Melas Marilena , Beltsios Eleftherios T. , Adamou Antonis , Koumarelas Konstantinos , McBride Kim L.
Published: December 2022

Hypertrophic cardiomyopathy (HCM) is an inherited myocardial disease with the presence of left ventricular hypertrophy (LVH). The disease is characterized by high locus, allelic and phenotypic heterogeneity, even among members of the same family. The list of confirmed and potentially relevant genes implicating the disease is constantly increasing, with novel genes frequently reported. Heterozygous alterations in the five main sarcomeric genes (MYBPC3, MYH7, TNNT2, TNNI3, and MYL2) are estimated to account for more than half of confirmed cases. The genetic discoveries of recent years have shed more light on the molecular pathogenic mechanisms of HCM, contributing to substantial advances in the diagnosis of the disease. Genetic testing applying next-generation sequencing (NGS) technologies and early diagnosis prior to the clinical manifestation of the disease among family members demonstrate an important improvement in the field.
Recognition of Emotion from Verbal and Nonverbal Expressions and Its Relation to Effective Communication: A Preliminary Evidence of a Positive Link
Authors: Israelashvili Jacob , Fischer Agneta
Published: December 2022

Previous work has shown that emotion recognition is positively related to effective social interactions, but the mechanism underlying this relationship has remained largely unclear. Here, we examined the possibility that people who understand others’ emotions also talk to them using similar language. In the current study participants (N = 106) listened to emotional stories people shared from their own lives. They were later asked to recognize the storytellers’ feelings and finally provide written support messages. Perceivers’ ability to accurately recognize others’ feelings was assessed using the Emotional Accuracy Test (EAT), which uses naturalistic verbal and nonverbal emotional cues, and using two standard tests of nonverbal emotion recognition (GERT, RMET). The language of the expressor (target) was compared to the language of the supporter (participant) to quantify Language Style Matching, a proxy for effective communication. People who perform better in emotion recognition with verbal cues (EAT) also communicate their understanding and support using language similar to the expresser (r = .22, p = .02). This relation was insignificant for tests without verbal information (RMET, GERT). The result provides additional construct validation for the EAT and supports the view that understanding the emotions of others and communicating with them are two manifestations of a broader interpersonal skill.