bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical case of acute food-protein induced enterocolitis syndrome (FPIES) as a manifestation of multiple food allergies
Authors:   Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University, Moscow, Russian Federation, Filippova E.A. , Esakova N.V. ,   Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University, Moscow, Russian Federation, Varlamov E.E. ,   Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University, Moscow, Russian Federation, Pampura A.N. ,   Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: July 2023

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy manifested by delayed onset of gastrointestinal symptoms (1–4 hours after allergen consumption), which can lead to severe life-threatening conditions. The absence of specific laboratory markers of FPIES allowing to determine the trigger and confirm the diagnosis, unclear clinical features often masked by acute intestinal infections and other gastrointestinal diseases create significant difficulties in identifying patients with FPIES, choosing the right tactics for their management, and prescribing an adequate elimination diet. This article presents a clinical case of a patient who had multiple episodes of severe clinical manifestations of FPIES since the age of 6 months, requiring emergency hospitalization. The diagnosis of FPIES was first suspected at the age of 1.5 years; subsequently, the diagnosis was clinically confirmed, and a plan for further management of the child was developed. Key words: food protein-induced enterocolitis syndrome (FPIES), children, diagnosis, food allergy, trigger, oral food challenge test, cow’s milk protein allergy, meat allergy
Stress Evolution and Permeability Enhancement Mechanism of Multistage Cavity Completion in Coalbed Methane Horizontal Wells
Authors: Yang Ruiyue , Chen Jianxiang , Qin Xiaozhou , Huang Zhongwei , Li Gensheng , Liu Liangliang
Published: July 2023

Coalbed methane (CBM) is an important clean energy resource. However, low gas production rate, especially in areas where hydraulic fracturing is notoriously inefficient, is the major obstacle that restricts the commercial development of CBM. Multistage horizontal well cavity completion has been observed to be successful in improving gas production rates in the Zhengzhuang block, Qinshui Basin, China. It has resulted in rates that are 1.5 times higher than the average production level achieved through horizontal well hydraulic fracturing. However, the stimulation mechanisms and major factors determining completion efficiency are still poorly understood. In this paper, we established a numerical model using the finite discrete element method (FDEM) to compute the stress evolution and fracture-network patterns. The accuracy of the model has been confirmed by analytical and numerical solutions. Subsequently, a series of parametric studies were performed to quantitatively analyze the mechanisms of multistage cavities influencing the stress evolution and fracture geometries in CBM reservoirs. Finally, we investigated a field case in an actual horizontal well located at the Qinshui Basin, where 17 cavity stages were completed. This case study further shed light upon the well completion strategies and optimization decisions. Implications and suggestions were also provided for field treatments to enhance the completion efficiency. The results demonstrate that FDEM can provide new insights into cavity completion mechanisms by explicitly accounting for fracture and fragmentation process at the field scale. The complex-fracture networks originated from multistage cavities consist of cavity-induced shear fractures, tensile fractures, mixed-mode fractures, and activated multiscale natural fractures, which is the primary reason for enhanced permeability and the essential difference from hydraulic fracturing. Compared with a single cavity, the interactions among multiple cavities can further promote the fracture-network connectivity and thus enlarge the stress-relief area and fracture area substantially. The selections of cavity geometrical parameters, including spacing, length, diameter, and number, have significant impacts on stress evolution (both magnitude and stress-relief area) and fracture patterns (such as fracture-network geometry, interconnectivity, propagation direction, and area). Stress evolution and fracture patterns reproduced from a field case in the Qinshui Basin can provide critical learnings for the industry in designing horizontal well cavity completion schemes. The key findings of this study are expected to deliver fundamental and practical guidelines for the horizontal well cavity completion in CBM or other unconventional oil and gas exploitation.
Machine learning reveals parsimonious differential model for myricetin degradation from scarce data
Authors: Fulkerson Andrew , Bayram Ipek , Decker Eric A. , Lu Jiakai , Corvalan Carlos M.
Published: July 2023

Accurately describing the degradation of food antioxidants in oil emulsions, bulk oils, and other foods is essential to understanding and controlling the factors that influence emulsion stability, such as antioxidant concentration. Here, we used a machine learning approach to discover a parsimonious differential equation that describes how myricetin degrades in soybean oil. The differential equation is based on a small experimental dataset, but it describes the degradation of myricetin over a wide range of initial concentrations and extrapolates well beyond the learning data. This information could be used to develop food products with improved shelf life. The machine learning approach we used has the potential to be applied to discover governing equations for other complex food systems, particularly those where the underlying dynamics are difficult to capture from limited experimental data.
Antivirus Solution to IoT Malware Detection with Authorial Next-Generation Sandbox
Authors: Silva Sthéfano , Lima Sidney Marlon Lopes , Pinheiro Ricardo Paranhos , Abreu Liosvaldo Mariano Santiago , Lima Rafael Diniz Toscano , Fernandes Sérgio Murilo Maciel
Published: July 2023

Background: Nowadays, the Internet of Things (IoT) significantly impacts people’s lives, reaching hundreds of billions of devices connected to the world wide web. Given the popularity of smart devices, the amount of cyber-attacks targeting technology has grown in the last few years. Malware is currently the main cyber-villain in IoT situations due to the ongoing emergence of new malware targeted at IoT, such as the botnet, the use of sophisticated obfuscation and evasion tactics, and frequently the availability of enormous resources for its development.
Objective: The present work creates an Antivirus for Dynamic Malware Analysis based on Artificial Neural Networks, equipped with authorial emulated IoT Sandbox. Our antivirus is specialized in malware detection from 32-bit IoT architectures of the Advanced RISC Machine (ARM) type. Methods: In the proposed methodology, the suspected ELF file for 32-bit ARM architecture is executed with the objective of intentionally infecting the audited GNU/Linux. In opposition to analysis of individual events, our engine employs authorial Next-Generation Sandbox. In all, our antivirus monitors and statistically weighs 2,793 actions that the suspicious ELF file can perform when executed.
Results: Our antivirus reaches an average accuracy of 98.75% when distinguishing benign ARM ELF files from malware. Our antivirus architectures are probed under different learning functions and starting conditions to maximize their accuracy.
Conclusions: The lack or limited detection of malicious software by commercial antivirus programs can be provided by Smart Antivirus. Instead of models based on blocklists, signatures or heuristics, our antivirus allows the detection of ARM ELF malware in a preventive and non-reactive way. Our antivirus overcomes limitations of Clamav and other traditional antiviruses.
Accounting for local categorizations and classifications of fish: Towards a food-centred governance of small-scale fisheries in coastal Kenya
Authors: Allegretti Antonio , Omukoto Johnstone
Published: July 2023

Burdened with food insecurity and inadequate nutrition, countries in the Global South have ample margins to benefit from more consideration for fish and aquatic foods for better nutrition. This article proposes the case of Kenyan coastal fisheries as a potentially crucial reservoir of food-related benefits for the poor and local communities, provided that a food-centred lens or approach are mainstreamed in local and national governance. Borrowing insights from post-structuralist maritime social sciences, and with evidence from the two coastal communities of Shimoni and Watamu, this article presents an ethnographic account of grassroots practices in-the-making such as handling, sorting, and allocating fish once caught, and how these practices lead to local categorizations and classifications of fish. This sort of evidence and knowledge around local categorizations and classifications of fish enables to delve into questions of access, availability, affordability, and agency that are crucial for a nutrition-sensitive approach to governance of fisheries. Through the analysis of the two different locations of Watamu and Shimoni in terms of the fisheries economy and overall development, the analysis of these categories and classifications highlights the necessity to account for a fairer access and distribution rather than solely production (of fish) that is overly market-oriented or exported.
Las familias rurales en Colombia: discusiones en torno a las posturas familistas y no familistas
Authors: Arias-Vásquez Yesenia , Pérez Zapata Elizabeth , Posada Pérez Natalia María
Published: July 2023

El propósito de esta investigación es contrastar las posturas familistas y no familistas en publicaciones en torno a la ruralidad colombiana en el periodo 2016 a 2021, teniendo en cuenta la trayectoria de ambos enfoques a la luz de los cambios en la conformación de las familias rurales en el país. El estudio es de carácter cualitativo, a través de la revisión de literatura con un alcance exploratorio descriptivo, acudiendo a técnicas de análisis inferencial del contenido en la producción académica. En este sentido, se retoman postulados de los estudios de género y se tienen en cuenta los aportes del construccionismo social. Se concluye que, a pesar de la transformación en las familias rurales, las concepciones familistas y las no familistas coexisten en las investigaciones sobre ruralidad en Colombia, en donde el género, las prácticas económicas y la organización social son los nodos que muestran mayores variaciones y similitudes entre ambas concepciones.
Blood Transfusion for Iron Deficiency Anaemia in Antenatal and Postnatal in
Maternal Specialist Hospital, 2018-2019: An Analytical Cross-sectional Study
Authors: Albafta Fatema , Elgergawi Taghrid
Published: July 2023

Objective:

Estimate the proportion and outcomes of blood transfusion in iron deficiency anemia in a specialist maternal hospital in Dubai, United Arab Emirates (UAE).

Methods:

In a cross-sectional study, data were collected from 177 pregnant inpatients and delivered outpatients with haemoglobin less than 12g/dL at the hospital in Dubai (UAE) between the 1st of February 2018 to 31st of January 2019. Sociodemographic factors were age, parity (number of birth to a live neonate or gestational age more than 24 weeks), and ethnicity. The outcome variable is blood transfusion. Different variables such as age, parity, nationality, gestational age at diagnosis, most severe haemoglobin reading, serum ferritin, haemoglobin electrophoresis, treatment, gestational age at delivery, mode of delivery, postpartum haemorrhage, neonatal birthweight, neonatal haemoglobin were tested using frequencies and means (standard deviation), chi-square and sample T-test was used.

Results:

One hundred and seventy-seven ladies had anemia, and one hundred and twenty-two (68%) had iron deficiency anemia (ferritin<30ng/dL). 52.5% (N=93) had moderate to severe anemia, and only 7.3% (N=13) received a blood transfusion. Anaemia was mostly diagnosed in the first trimester (40.7%; N=72) and second trimester (38.4%; N=68). 11 (6.2%) ladies had hemoglobinopathies such as beta-thalassemia, 138 (78%) ladies didn’t have hemoglobin electrophoresis reading. 37.9% (N=67) of vaginally delivered ladies and 4.5% (N=8) of cesarean section-delivered ladies had a postpartum hemorrhage. The majority of anemic antenatal and postnatal were Emiratis (74.6%; N=132), and a greater number fell in the middle age group between 30-39 (58.2%; N=103). The larger part had normal neonatal birthweight (76.8%; N=136) and only had a low neonatal birthweight (18.1%; N=32). 105 (59.3%) of neonates had abnormal hemoglobin readings.

Conclusion:

This is the first study in the UAE that assess both maternal and fetal outcome due to iron deficiency anemia in pregnant ladies. The prevalence of blood transfusion increased as iron deficiency anaemia was more severe. We endorse health practitioners to regularly measure serum haemoglobin, to treat anaemia early in pregnancy to avoid the need for blood transfusion.
Development of Dual Inhibitors of Soluble Epoxide Hydrolase/Fatty Acid
Amide Hydrolase with Tetrazole Core
Authors: Mehrandish Sara , Rezaee Elham , Sedaghat Anna , Heidarli Elmira , Naderi Nima , Tabatabai Sayyed Abbas
Published: July 2023

Introduction:

The attractive biological actions of the eicosatrienoic acids (EETs) and
endocannabinoids (eCBs) are terminated by means of enzymatic hydrolysis via soluble epoxide hydrolase
(sEH) and fatty acid amide hydrolase (FAAH) enzymes. Simultaneous inhibition of both
enzymes is considered a novel approach in the treatment of inflammatory and neuropathic pain.

Methods:

In this study, a novel series of tetrazole derivatives as dual sEH/FAAH inhibitors were
designed, synthesized, and biologically evaluated. Compounds 6c, 7d, and 8a, the most potent inhibitors
against FAAH and sEH enzymes with acceptable IC50 values, significantly decreased carrageenan-
induced paw edema 5h after carrageenan injection compared to the control group compound. In
addition, compound 7d exhibited a significant reduction in pain scores compared to the control
group.

Results:

Docking studies showed that the presented dual inhibitors could bind to the essential residues
in the catalytic sites of both enzymes. In silico prediction of several pharmacokinetic properties
suggests that these dual inhibitors could potentially be orally active agents.

Conclusion:

These structures will be a valuable scaffold to develop soluble epoxide hydrolase inhibitors
with dual potency towards fatty acid amide hydrolase.
Recent Advances in the Nanotechnology-Based Applications of Essential
Oils
Authors: Zhang Lei , Lin Jingyi , Zhang Can , Hu Sijing , Dong Yang , Fan Guanwei , He Feng
Published: July 2023

Essential oils (EOs), which are volatile aromatic substances extracted from plants,
exhibit antibacterial, antitumor, antiviral, antioxidant, anti-inflammatory, and other effects. Eos
are widely used in different fields because of their various biological activities. EOs are volatile
and insoluble in water, so their effective utilization rate is greatly reduced. In this regard, researchers
propose to use nanotechnology to construct an EOs nanosystem to solve the application
problems and improve the utilization rate of EOs. This review summarizes the latest research
progress and application status of EOs nanocapsules, EOs nanoemulsion, EOs nanofiber
membrane, EOs nanoparticles and EOs nanoliposome, including the methodologies, characteristics
and applications.Analyzes the advantages and disadvantages of existing EOs nanotechnology
and provides an outlook for future development.
Planning Guidelines for the Development of Urban Periphery - Case of Akola
Authors: Raut Radhika R. , Bhatia Kuldeep Kaur , Paithankar Tushar
Published: July 2023

Abstract: The growth of any City, Village or Settlement is totally depend on, the opportunities it gives to the people in terms of the economic development and accommodation. Urbanization has caused the development of an area beyond its original municipal limits which leads to the haphazard growth of the city. This has caused the transformation of villages from rural to urban; giving them mixed characteristics of village and city. Rapid urbanization is the main cause of emergence of the urban periphery as well as slums in the cities. Urbanization is caused due to industrialization, as the small town grows into city, people starts migrating to city. As the urban land holds a very high value the lower income groups cannot afford them and starts living in the outskirts of the city which leads to the growth of urban peripheral area.
Zmiany w polskim handlu zagranicznym roślinami ozdobnymi w latach 2005-2012
Authors: Jabłońska Lilianna , Olewnicki Dawid , Kowalczyk Dominika
Published: July 2023

Celem pracy było zbadanie zmian w polskim handlu zagranicznym roślinami ozdobnymi od 2005r., czyli pierwszego pełnego roku członkostwa w UE. Badano kierunek i dynamikę zmian w eksporcie i imporcie, strukturę asortymentową oraz saldo obrotów, zarówno w ujęciu wartościowym, jak i ilościowym. Analizowano także zmiany i relacje cen importowych i eksportowych. Badania wykazały stały wzrost obrotów, szybszy importu w ujęciu wartościowym, zaś eksportu w ilościowym, przy ujemnym bilansie. Polska jest rosnącym importerem netto głównie kwiatów ciętych żywych, doniczkowych i cebul kwiatowych Wzrasta także w imporcie znaczenie roślin szkółkarskich, będących równocześnie podstawą polskiego eksportu. Eksportuje się ich coraz więcej, ale po coraz niższych cenach. W przypadku pozostałych grup roślin odnotowano wyraźny wzrost cen w eksporcie, ale w dalszym ciągu są niższe niż w imporcie.
Cardiovascular Autonomic Neuropathy and Risk of Kidney Function Decline in Type 1 and Type 2 Diabetes: Findings From the PERL and ACCORD Cohorts
Authors: Tang Yaling , Ang Lynn , Jaiswal Mamta , Dillon Brendan R. , Esfandiari Nazanene H. , Shah Hetal S. , Spino Cathie , Plunkett Cindy , Perkins Bruce A. , Pop-Busui Rodica , Doria Alessandro
Published: July 2023

Results of previous studies have suggested that cardiovascular autonomic neuropathy (CAN) may predict rapid kidney function decline among people with diabetes. We analyzed the association between baseline CAN and subsequent glomerular filtration rate (GFR) decline among individuals with type 1 diabetes (T1D) from the Preventing Early Renal Loss in Diabetes (PERL) study (N = 469) and with type 2 diabetes (T2D) from Action to Control Cardiovascular Risk in Diabetes (ACCORD) (N = 7,973). Baseline CAN was ascertained with electrocardiogram-derived heart rate variability indices. Its association with GFR slopes, rapid kidney function decline (GFR loss of ≥5 mL/min/1.73 m2/year), and ≥40% GFR loss was evaluated by linear mixed-effects, logistic, and Cox regression, respectively. Participants with CAN experienced more rapid GFR decline, by an excess 1.15 mL/min/1.73 m2/year (95% CI −1.93 to −0.37; P = 4.0 × 10−3) in PERL and 0.34 mL/min/1.73 m2/year (95% CI −0.49 to −0.19; P = 6.3 × 10−6) in ACCORD. This translated to 2.11 (95% CI 1.23–3.63; P = 6.9 × 10−3) and 1.39 (95% CI 1.20–1.61; P = 1.1 × 10−5) odds ratios of rapid kidney function decline in PERL and ACCORD, respectively. Baseline CAN was also associated with a greater risk of ≥40% GFR loss events during follow-up (hazard ratio 2.60 [95% CI 1.15–5.45], P = 0.02, in PERL and hazard ratio 1.54 [95% CI 1.28–1.84], P = 3.8 × 10−6, in ACCORD). These associations remained significant after adjustment for potential confounders, including baseline GFR and albuminuria. Our findings indicate that CAN is a strong, independent predictor of rapid kidney function decline in both T1D and T2D. Further studies of the link between these two complications may help with development of new therapies to prevent kidney function decline in patients with diabetes.

Article Highlights
Hanamichi und Mie-Pose: Modern imprägnierte Versatzstücke des japanischen Kabuki in Max Reinhardts frühen Bühnenmodellen und Inszenierungskonzepten
Authors: Haitzinger Nicole
Published: July 2023

Dieser Artikel skizziert im ersten Teil die Wiener Theaterkultur in der zweiten Hälfte des 19.Jahrhunderts mit Akzentuierung des Japonismus, in der Max Reinhardt (1873-1943) sozialisiert wurde. Diese von der Forschung meist nur als Randnotiz erwähnte strukturelle und ästhetische Gebundenheit Reinhardts an die Wiener Moderne scheint mit entscheidend für das Verständnis seiner ersten Bühnenmodelle und Inszenierungskonzepte zu sein. Die Analyse der Inszenierung Sumûrun (1905) dient im zweiten Teil schließlich zu thesengeleiteten Antworten auf die Frage, welche spezifische Funktion die aus dem japanischen Kabuki entlehnten Versatzstücke Hanamichi (Blumensteg) und die Mie-Pose hatten und welche ästhetische Erfahrung sie evozierten.
XVI. YÜZYIL ŞAİRLERİNDEN HAMDÎ NİN MANZUM PEND-NÂME Sİ
Authors: Öztürk Uğur
Published: July 2023

Bu yazıda XVI. yüzyıl şairlerinden Hamdî’nin III. Murad’a ithafen
kaleme aldığı manzum pend-nâmesi incelenmiştir. Hamdî’nin Pend-nâme’si
hikâye ve mev’iza başlıklarıyla bu türün özelliğini taşımakla birlikte hasbihâl
başlığında şair kendi hayatına, devrine dair birçok bilgi vermiştir. Pend-nâme’de
ilk önce aşkın merhaleleri anlatılmış, âşık-maşûk ilişkileri, mecâzî aşka
yakalanmış âşığın akıbeti, İlahî aşka yöneliş ve hakîkî aşkı bulmanın yöntemleri
ve bu yoldaki nasihatler ele alınmıştır. Şair 477 beyitlik mesnevi tarzında yazdığı
eserine kendine ait beşer beyitlik iki tane de gazelini eklemiştir. Bu gazellerden
ilki aşk hakkındayken ikincisi devrin sultanının övgüsüne dairdir. Hamdî,
İstanbul dışında ismini belirtmediği bir yerde mülazemetini aldıktan sonra nâib
olmuş fakat bulunduğu yerde kadılığa yükselememiştir. Hocasının da vefatı
üzerine hamisiz kalmış ve kadılık hayali ile İstanbul’a gelmiştir. Kadı olmayı
beklerken bu kez de Kefe kadısı nâibliği ile görevlendirilmiştir. Bu görevine
giderken yolda bindiği gemi Karadeniz’de alabora olmuş ve tüm mal varlığını
kaybetmiştir. Manzumesini de bu kazadan sonra hâlini sultana arz etmek için
yazmıştır. 1577-1580 yılları arasında yazılmış olan eserde III. Murad’ın yanı sıra
şehzadesine, Valide Sultan Nurbanu Sultan’a, musahip Şemsî Ahmed Paşa’ya ve
isimleri belirtilmeden devrin vezirlerine övgüler vardır. Yazıda ilk önce pendnâme türü hakkında kısa bilgilere yer verilmiş ardından manzumenin sahibi ve
yazılış tarihi tespit edilmeye çalışılmıştır. Bu kısımdan sonra manzumenin şeklî
unsurları ile muhtevası incelenmiş ve metnin geniş özetinden sonra
transkripsiyonlu hâli de makaleye dâhil edilmiştir.
Research on Art Design of Urban Wetland Park Planning Based on the Concept of Sustainable Development
Authors: Zhou Zhenhong , Wang Shiqi , Zhao Ming , Zhi Fei
Published: July 2023

With the development of the social economy, the scale of cities has expanded rapidly, and the urban ecological imbalance has become increasingly severe, which has caused many urban problems. People gradually realise that cities and human beings develop more harmoniously and healthily by building and developing cities on the basis of natural ecology and seeking the harmonious coexistence of ecology and humanity. The results of the sustainable landscape ecological evaluation of Anhui Shilonghu National Wetland Park show that the park has good ecological, social, and economic benefits and functions. The urban ecological environment and social and economic development have a good supporting effect on the park, and its overall evaluation grade is good. Compared with other waterscape parks, the ecological function of urban wetland parks is the most basic and essential function of the landscape. It has multiple functions, such as popular science education and being close to nature and entertainment. Developing wetland ecological experience tourism activities benefits wetland protection and ecologically coordinated, sustainable development. It can also comprehensively improve wetland parks’ ecological, social, and economic benefits.
Evaluation of hypoglycaemic potency in tempe with soybean germination process and extended fermentation time
Authors: Abdurrasyid Z. , Astawan M. , Lioe H.N. , Wresdiyati T.
Published: July 2023

One of the potential hypoglycaemic food from Indonesia is tempe. The use of germinated soybean and the extended fermentation time are potential methods to increase hypoglycaemic activity. In this study, the potential hypoglycaemic activity of tempe due to the use of germinated soybeans as raw material and the extended fermentation time (observation of 48, 72, and 96 hrs) was evaluated. The observations included insulinotropic free amino acids, soluble protein, peptides profile, antioxidants capacity, isoflavones, total phenolic compounds, and the α- glucosidase inhibitor activity. During the extended fermentation time from 48 hrs to 96 hrs, the germinated soy tempe had the highest insulinotropic free amino acids level, while non-germinated soy tempe had the highest antioxidant components (isoflavones, total phenolic compounds, and antioxidants capacity). However, the activity of α-glucosidase inhibitor due to treatments was decreased, suspiciously related to the decrease of the 11.40 kDa peptide, which was dominant in this study. This study showed that the extended fermentation time from 48 to 96 hrs and the use of germinated soybean was able to increase the tempe hypoglycaemic potencies based on the insulinotropic free amino acids and antioxidant component, but not for α-glucosidase activity.
Analyzing the Dynamics of Islamic Stock Market Indices in Several Muslim Countries
Authors: Haryono Slamet , Atika Bella
Published: July 2023

Purpose: Analyzing stock price is very necessary to identify the overall price of the stock index, which the market players have various options and references to invest their money in the profitable securities portfolio. Based on the reason, the aim of this study is to examine the Islamic stock price movement in several Muslim countries joined in the Islamic Conference Organization (IOC).
 
Theoretical Framework: This study refers to the theoretical framework that the integrated capital market can help everyone in analyzing the quality and quantity of the Islamic stock price movement, including its challenges and opportunity in the context of investment risk management.
 
Design/Methodology/Approach: This research uses a descriptive-analytical method and comparative approach to examine the tends of Islamic stock price movement in six Muslim countries from the period January 2010 to December 2019, namely JII-Indonesia, DJIMY-Malaysia, DJTR-Turkey, DJIMKW-Kuwait, TDWL-Saudi Arabia, and QEAR-Qatar, which are analyzed quantitatively, statistically, and deductively.
 
Findings: The results of the research show that the co-integrated of Islamic Stock Index are JII-Indonesia with DJIMY-Malaysia, JII-Indonesia and DJIMKW-Kuwait, DJIMY-Malaysia with DJIMKW-Kuwait, DJTR-Turkey with DJIMKW-Kuwait, QEAR-Qatar with DJIMKW-Kuwait. The Islamic stock index pairs confirmed through the VAR and VECM tests are only DJIMY-Malaysia with QEAR-Qatar, DJIMY-Malaysia with DJIMKW-Kuwait, and TDWL-Saudi Arabia with QEAR-Qatar.
 
Research, Practical & Social Implications: This study becomes one example of the practical analysis of Islamic Stock Market movements that can be used to the stock market players in taking the consideration and decision for the investment in capital market.
 
Originality/Value:  This result of this study is originally limited in the Islamic stock index in six Muslim countries such as Indonesia, Malaysia, Turkey, Saudi Arabia, Qatar, and Kuwait. However, this can be explored more comprehensively in the same or various research objective by the other researchers.
The impact of robotics on development, of hot and cold executive functions, and their role in improving them in special education
Authors: Nikolaos Drakatos  , Antonios Christou
Published: July 2023

Executive function (EF) skills are neurocognitive skills that support the reflective, top-down coordination and control of other brain functions, and there is neural and behavioral evidence for a continuum from more "cool" EF skills activated in emotionally neutral contexts to more "hot" EF skills required for motivationally significant tendency reversal. EF problems are transdiagnostic markers of abnormal development. A neurodevelopmental model follows the path from bad childhood events and stress to disturbance of the development of brain systems supporting reflection and EF skills and an increased risk for general psychopathology traits. Educational robotics is generally concerned with researching the effects of building and programming robots on children's learning and academic accomplishment. We recently discovered that engaging in progressively more difficult robot planning and monitoring (ER-Lab) promotes visual-spatial working memory and response inhibition in early childhood during typical development, and that an ER-Lab can be a viable rehabilitative tool for children with Special Needs. Children with Special Needs (SN) had considerably enhanced inhibition skills, and children with attentional impairment had greater gains in inhibition of motor response tasks than children with a language deficiency. The study's findings and future prospects for how ER-Lab programs could become a strong tool in classrooms with special needs children are highlighted. The key also conclusion was that there was a considerable improvement in visuo-spatial attention as well as a significant effect on robot programming skills. According to research, EF abilities can be developed through scaffolded training and are a promising therapeutic and preventive intervention target. Intervention efficacy can be increased by reducing disruptive bottom-up effects like stress, teaching both hot and cool EF skills, and incorporating a reflective, metacognitive component to facilitate far transfer of trained skills.
Use of Green Industry 5.0 Technologies in Logistics Activities
Authors: Trstenjak Maja , Mustapić Miljenko , Gregurić Petar , Opetuk Tihomir
Published: July 2023

Industry 5.0 is a human-centred concept of industrial development towards the sustainable and resilient system presented by the European Union which aims to become the global both innovation and industrial leader. It should overcome the barriers of the previously presented Industry 4.0. This paper presents the research conducted in the 112 Croatian manufacturing companies, dealing with their awareness level of the Industry 5.0, as well as the use of green and digital elements in logistics activities. The results have shown that the awareness of the digital concept of both Industry 4.0 or 5.0 remains low, but the companies are more open towards the implementation of the green elements than the digital ones, with the potential for future development recognized.
Metode Fatwa MPU (Majelis Permusyawaratan Ulama) Aceh
Authors: Muchtar Nurkhalis
Published: July 2023

Fatwa merupakan sebuah proses memberikan kepastian hukum terhadap persoalan yang muncul yang ditanyakan kepada mufti. Kebutuhan umat terhadap fatwa dimulai semenjak awal perkembangan Islam, yang ditandai dengan hadirnya Rasul sebagai figur pertama pemberi fatwa. Dalam Islam fatwa memiliki kedudukan penting, sehingga orang-orang yang memberi fatwa tentunya harus memiliki kompetensi dan kapasitas keilmuan yang memadai. sejauh penelitian, belum didapatkan karya yang secara khusus mengkaji mengenai metode fatwa Majelis Permusyawaratan Ulama Aceh, mengingat fatwa yang dikeluarkan oleh Majelis Permusyawaratan Ulama Aceh memiliki pengaruh yang besar dalam masyarakat Aceh. Penelitian ini dilakukan untuk menjawab dua pertanyaan besar yang menjadi rumusan masalah yaitu bagaimana metode fatwa MPU Aceh dan penerapannya? bagaimana kaitan metode fatwa MPU Aceh terhadap fatwa penetapan kitab ghair mu’tabar? Dalam menjawab dua pertanyaan besar ini, peneliti menggunakan penelitian deskriptif kualitatif dengan menggunakan dua pendekatan yaitu penelitian kepustakaan yang akan mengkaji mengenai fatwa secara mendalam dan sejarah MPU Aceh beserta fatwa-fatwanya. Pendekatan yang kedua ialah dengan penelitian lapangan, untuk mengkaji sejauh mana efek fatwa kitab ghair mu’tabar dalam masyarakat. Adapun kerangka teori yang digunakan dalam penelitian ini ialah menggunakan teori para ulama dan ilmuan Islam yang menulis tentang fatwa keagamaan. Penelitian ini diharapkan sebagai upaya memahami proses hadirnya fatwa yang tepat sasaran, sehingga dapat tercipta stabilitas dalam kehidupan, terwujudnya keadilan, kemanfaatan serta kesejahteraan dalam kehidupan bermasyarakat, berbangsa dan bernegara.
Tingkat Demokrasi dan Pemenuhan Universal Health Coverage: Reassesment lintas negara
Authors:   Universitas Brawijaya, Anggraeni Tiffany Pamela , Fahadayna Adhi Cahya
Published: July 2023

Ketimpangan akses kesehatan harus menjadi fokus utama dari pemerintah suatu negara. Pemenuhan akses kesehatan diwujudkan oleh pemerintah global melalui pemenuhan Universal Health Coverage (UHC). UHC adalah target dari pemerintah untuk mewujudkan layanan kesehatan bagi seluruh elemen masyarakat tanpa adanya hambatan finansial. Pemenuhan UHC di suatu negara sering dikaitkan dengan kualitas sistem negara karena akan berpengaruh terhadap hasil UHC. Penelitian ini bertujuan untuk melihat dampak sistem negara terhadap pemenuhan UHC di suatu negara. Metode penelitian yang digunakan adalah kuantitatif dengan teknik analisis regresi sederhana. Data yang diambil adalah kualitas demokrasi egaliter dari V-Dem serta indeks Universal Health Coverage dari Global Burden of Disease. Kurun waktu yang digunakan adalah tahun 1990, 2010, dan 2019 dengan total negara sebanyak 171. Berbeda dengan literatur terdahulu, hasil assessment menunjukkan bahwa kualitas demokrasi tidak berpengaruh signifikan terhadap pemenuhan UHC di negara autokrasi dan negara yang sedang mengalami demokratisasi. Maknanya, terdapat faktor lain yang lebih signifikan untuk mempengaruhi pemenuhan UHC di negara autokrasi dan negara demokratisasi. Sedangkan, kualitas demokrasi pada negara demokratis berpengaruh signifikan terhadap pemenuhan UHC. Kondisi tersebut terjadi karena masing-masing negara memiliki pandangan tersendiri untuk mewujudkan layanan kesehatan, sehingga efek kualitas demokrasi akan berbeda-beda.
The dynamic organization of the neuronal postsynaptic membrane
Authors:   , Westra Manon
Published: July 2023

This thesis explores the dynamic organization of glutamate receptors and membrane lipids in the postsynaptic membrane of neurons. It aims to understand how the arrangement of these components influences synaptic transmission and brain function. The study utilizes advanced super-resolution microscopy techniques to visualize and track individual molecules at the nanoscopic scale. The thesis begins with an overview of the importance of membrane composition in protein organization within the postsynapse. It highlights the challenges in studying this field and introduces the use of super-resolution microscopy for visualizing protein and lipid distribution. A protocol for single-molecule localization microscopy is presented to examine the subsynaptic localization of synaptic proteins. Next, the focus shifts to the dynamics of lipids and proteins within the synaptic membrane. The thesis delves into a methodology for tracking individual molecules in living cells and the subsequent analysis of their movement and diffusion. Simulated trajectories are employed to optimize experimental parameters for studying complex molecular organization.
The subsequent chapters investigate specific glutamate receptor subtypes. Chapter 5 examines the AMPA receptor, particularly the GluA3-containing subtype. The distribution and dynamics of GluA3-containing AMPARs are compared to GluA1-containing AMPARs within the postsynaptic membrane. Chapter 6 focuses on the metabotropic glutamate receptor mGluR5, exploring its distribution and dynamics in relation to the postsynaptic density. The perisynaptic localization of mGluR5 and its significance are described. Chapter 7 explores methods for studying the dynamic organization of membrane lipids. This includes analyzing lipid diffusion behavior and distribution patterns, as well as investigating the effects of altering lipid composition on receptor organization.
Overall, the thesis provides valuable insights into the nanoscale organization of glutamate receptors and membrane lipids in the postsynaptic membrane. It enhances our understanding of synaptic architecture and its impact on synaptic transmission and brain function.
Epidemiological characteristics of SHV, cmlv, and FosA6-producing carbapenem-resistant Klebsiella pneumoniae based on whole genome sequences in Jiangsu, China
Authors: Zhu Jiaying , Ju Yanmin , Zhou Xinyu , Chen Taoyu , Zhuge Xiangkai , Dai Jianjun
Published: July 2023

Carbapenem-resistant Klebsiella pneumoniae (CRKP), particularly those with high virulence, cause invasive disease in clinical settings. An epidemiological investigation was conducted on the evolution, virulence, and antimicrobial resistance of CRKP isolates in two tertiary teaching hospitals in Jiangsu, China from November 2020 to December 2021. There were 31 different CRKP strains discovered. We performed whole genome sequencing (WGS) on 13 SHV, cmlv, and FosA6-producing CRKP to reveal molecular characteristics. Five ST15/ST11 isolates had CRISPR-Cas systems. By conjugation tests, KPC-2 can be transmitted horizontally to E. coil. A conjugative pHN7A8-related multi-resistance plasmid (KPC-2, blaCTX-M-65, blaTEM-1, fosA3, catII, and rmtB) was first discovered in CRKP clinical isolates. Using bacteriological testing, a serum killing assay, and an infection model with Galleria mellonella, three ST11-K64 KPC-2 generating carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) were identified. These strains harbored a virulent plasmid and an IncFII-family pKPC/pHN7A8 conjugative plasmid, which led to hypervirulence and resistance. One of these CR-hvKPs, which co-harbored KPC-2, NDM-6, SHV-182, SHV-64, and blaCTX-M-122 genes, was first discovered. Importantly, this CR-hvKP strain also produced biofilm and had non-inferior fitness. The widespread use of ceftazidime/avibactam might provide this CR-hvKP with a selective advantage; hence, immediate action is required to stop its dissemination. Another important finding is the novel ST6136 in K. pneumoniae. Finally, the sterilization efficiency rates of Fe2C nanoparticles in CRKP were more than 98%. Furthermore, our novel antibacterial Fe2C nanoparticles may also provide a therapeutic strategy for infections.
Causal effect of vitamin D on myasthenia gravis: a two-sample Mendelian randomization study
Authors: Fan Yidan , Huang Huaiying , Chen Xiangda , Chen Yuexuan , Zeng Xiashi , Lin Fenwei , Chen Xu
Published: July 2023

Introduction

Observational studies suggest that vitamin D supplementation may be effective in preventing myasthenia gravis (MG). However, the causal relationship between circulating vitamin D levels and MG remains unclear. This study aimed to examine the genetic causality of circulating vitamin D and MG using data from large population-based genome-wide association studies (GWAS).

Methods

SNPs (single nucleotide polymorphisms) strongly associated with exposure were selected. Two-sample Mendelian Randomization (MR) was performed with inverse variance weighting (IVW), MR-Egger (Mendelian randomization-Egger), weight median and MR-PRESSO (Mendelian randomization pleiotropy residual sum and outlier) methods. Heterogeneity was tested via IVW and MR-Egger. Pleiotropy was tested using MR-Egger intercept test and MR-PRESSO method. MR-PRESSO was also used to detect outliers. Leave-one-out analysis was used to identify SNPs with potential effect. Reverse MR analysis was also performed.

Result

In IVW, circulating vitamin D levels had no causal effect on MG [OR = 0.91 (0.67–1.22), p = 0.532] and MG had no causal effect on circulating vitamin D [OR = 1.01 (099–1.02), p = 0.663]. No heterogeneity or pleiotropy was observed (p > 0.05). Other MR methods also agreed with IVW results.

Conclusion

This study provides the causal relationship between genetically predicted circulating vitamin D levels and MG and provides new insights into the genetics of MG.
Effects of intermittent fasting on quality of life tolerance of chemotherapy in patients with gynecological cancers: study protocol of a randomized-controlled multi-center trial
Authors: Schmidt Mona Wanda , Brenner Walburgis , Gebhard Susanne , Schmidt Marcus , Singer Susanne , Weidenbach Lina , Hahn Harriett , Puzankova Diana , Blau-Schneider Bettina , Lehnert Antje , Battista Marco Johannes , Almstedt Katrin , Lütkemeyer Anja , Radsak Markus Philipp , Mähringer-Kunz Aline , Krajnak Slavomir , Linz Valerie Cathrine , Schwab Roxana , Gabriel Boris , Hasenburg Annette , Anic Katharina
Published: July 2023

Fatigue is a very common side effect during intravenous chemotherapy. Unfortunately, only few effective therapeutic options are available, mostly based on daily activity. In our pilot trial we were able to demonstrate that intermittent fasting can reduce fatigue in healthy people, thus we aimed to assess the effects of the fasting dietary on quality of life during chemotherapy in patients with gynecological cancer, especially on the domain of fatigue. The IFAST trial is designed as a prospective, randomized-controlled, multi-center trial. Participation will be offered to women with gynecological cancers (breast cancer, ovarian cancer including peritoneal and fallopian tube cancers, endometrial cancer and cervical cancer) who are planned to receive intravenous chemotherapy for at least three months. Eligible patients will be randomized 1:1, stratified by tumor type and study center. Primary endpoint is the difference in mean change in fatigue, assessed with the Functional Assessment of Chronic Illness Therapy-Fatigue Scale (FACIT- FS©). Exploratory secondary endpoints will include general Quality of Life impairment, tolerance of chemotherapy, immunological changes, peripheral cell damage in blood cells, as well as tumor response to chemotherapy. There is new evidence that prolonged fasting periods of 46-96 hours during chemotherapy can positively influence the quality of life during chemotherapy. However, these fasting regiments are not feasible for many patients. Intermittent fasting could be a feasible (manageable) option for many patients to actively improve their quality of life and tolerance to chemotherapy and possibly even enhance the effectiveness of chemotherapy.

Trial Registration

https://drks.de, identifier DRKS00031429.
Case report: Clinicopathological and molecular characteristics of pediatric-type follicular lymphoma
Authors: Ren Beibei , Chen Yu , Bai Xuanye , Zheng Jiawen , Chang Jing , Jiang Xiangnan , Xia Qingxin , Zhang He
Published: July 2023

Pediatric-type follicular lymphoma (PTFL) is a rare pediatric-type indolent B-cell lymphoma that clinicopathologically differs from adult lymphoma. Accurate diagnosis of PTFL, which is often challenging, is essential to avoid missed diagnosis, misdiagnosis, and overtreatment. To improve our understanding of PTFL, clinicopathological features, differential diagnosis, and molecular mutation characteristics of four patients of PTFL were analyzed using hematoxylin and eosin staining, immunohistochemistry, polymerase chain reaction, fluorescence in situ hybridization (FISH), and next-generation sequencing (NGS). A relevant literature review was also performed. All four PTFL patients were male, with ages of 6, 18, 13, and 15 years, and had St. Jude stage I or III. Microscopic results showed that the structure of the lymph nodes was destroyed; the tumor follicles were enlarged and irregular; medium–large blastoid cells with a consistent shape were visible in tumor follicles, and the nucleus was round or oval; and the “starry sky” pattern was easily observed. Tumor cells expressed CD20, PAX-5, BCL6, and CD10. None of the tumor cells expressed BCL2, CD3, CD5, MUM1, and CyclinD1. CD21 showed dilated growth of a follicular dendritic cell network in tumor follicles. EBER genes were negative in all cases. FISH testing also showed negative BCL2 gene breaks and IRF4 gene breaks in all cases. NGS detected 12 related mutant genes, including KMT2D, CD79B, GNA13, MYD88, PCLO, TCF3, IRF8, MAP2K1, FOXO1, POLE, INPP5D, and FAT4. Two of the four patients had an IRF8 gene mutation, and one patient had a dual mutation of the MAP2K1 gene. Our study revealed the unique clinicopathological features and molecular mutational characteristics of PTFL, consolidated our understanding of PTFL, and identified other rare mutant genes, which may further contribute to the study of the molecular mechanism and differential diagnosis of PTFL.
Scientific connotation of the compatibility of traditional Chinese medicine from the perspective of the intestinal flora
Authors: Gao Yuan , Wu Xiaoxia , Zhao Ning , Bai Dong
Published: July 2023

Revealing the connotation of the compatibility of Chinese medicines (CM) is a requirement for the modernization of traditional Chinese medicine (TCM). However, no consensus exists on the specific mechanism of traditional Chinese medicine compatibility (TCMC). Many studies have shown that the occurrence and development of diseases and the efficacy of CM are closely related to intestinal flora (IF), which may provide a new perspective to understand the theory of TCM. This study aimed to summarize the relationship between the changes in IF before and after the compatibility of different drugs and the synergistic, toxicity reduction, and incompatibility effects of drug pairs from the perspective of the effects of CM on the IF and the regulation of microbial metabolites. These studies showed that the effect of drug pairs on the composition of the IF is not a simple superposition of two single drugs, and that the drug pairs also play a specific role in regulating the production of intestinal bacterial metabolites; therefore, it has a different pharmacodynamic effect, which may provide a perspective to clarify the compatibility mechanism. However, research on the interpretation of the scientific connotations of TCMC from the perspective of the IF is still in its infancy and has limitations. Therefore, this study aimed to summarize previous research experience and proposed to conduct a deep and systematic study from the perspective of drug pair dismantling, IF, intestinal bacteria metabolite, organism, and disease to provide a reference for scientific research on the compatibility mechanism of CM.
Application of antimicrobial peptides in plant protection: making use of the overlooked merits
Authors: Tang Rui , Tan Hui , Dai Yan , Li Lin’ai , Huang Yan , Yao Huipeng , Cai Yi , Yu Guozhi
Published: July 2023

Pathogen infection is one of the major causes of yield loss in the crop field. The rapid increase of antimicrobial resistance in plant pathogens has urged researchers to develop both new pesticides and management strategies for plant protection. The antimicrobial peptides (AMPs) showed potential on eliminating plant pathogenic fungi and bacteria. Here, we first summarize several overlooked advantages and merits of AMPs, which includes the steep dose-response relations, fast killing ability, broad synergism, slow resistance selection. We then discuss the possible application of AMPs for plant protection with above merits, and highlight how AMPs can be incorporated into a more efficient integrated management system that both increases the crop yield and reduce resistance evolution of pathogens.