bluuebunny/crossref_metadata_2025 huggingface dataset:
Caspase-Independent Regulated Necrosis Pathways as Potential Targets in Cancer Management
Authors: Lou Jianyao , Zhou Yunxiang , Feng Zengyu , Ma Mindi , Yao Yihan , Wang Yali , Deng Yongchuan , Wu Yulian
Published: February 2021

Regulated necrosis is an emerging type of cell death independent of caspase. Recently, with increasing findings of regulated necrosis in the field of biochemistry and genetics, the underlying molecular mechanisms and signaling pathways of regulated necrosis are gradually understood. Nowadays, there are several modes of regulated necrosis that are tightly related to cancer initiation and development, including necroptosis, ferroptosis, parthanatos, pyroptosis, and so on. What’s more, accumulating evidence shows that various compounds can exhibit the anti-cancer effectviainducing regulated necrosis in cancer cells, which indicates that caspase-independent regulated necrosis pathways are potential targets in cancer management. In this review, we expand the molecular mechanisms as well as signaling pathways of multiple modes of regulated necrosis. We also elaborate on the roles they play in tumorigenesis and discuss how each of the regulated necrosis pathways could be therapeutically targeted.
Predicting Therapeutic Response in Pediatric Ulcerative Colitis—A Journey Towards Precision Medicine
Authors: Colman Ruben J. , Dhaliwal Jasbir , Rosen Michael J.
Published: February 2021

Ulcerative colitis (UC) is a disabling disease, characterized by chronic inflammation of the colon, with a rising prevalence worldwide in the pediatric age group. Although UC presents in children with varying severity, disease extent, and comorbidities, initial treatment is essentially uniform, consisting of 5-aminosalicylate drugs with corticosteroid induction for those with moderately to severely active disease. With the advent of anti-tumor necrosis factor (TNF) biologic therapy and several new biologics and small-molecule drugs for UC, precision medicine approaches to treatment are needed to more rapidly achieve sustained remission, restore quality of life, normalize development, and limit exposure to toxic corticosteroids in children with UC. Here, we review available data on clinical, biochemical, histopathologic, and molecular predictors of treatment response in UC. We also address known predictors and special treatment considerations in specific relevant scenarios such as very-early-onset UC, acute severe UC, ileal pouch anal anastomosis, and UC with concomitant primary sclerosing cholangitis. The review concludes with a prediction of how machine learning will integrate multimodal patient data to bring precision medicine to the bedside of children with UC in the future.
Einstein, Planck and Vera Rubin: Relevant Encounters Between the Cosmological and the Quantum Worlds
Authors: Salucci Paolo , Esposito Giampiero , Lambiase Gaetano , Battista Emmanuele , Benetti Micol , Bini Donato , Boco Lumen , Sharma Gauri , Bozza Valerio , Buoninfante Luca , Capolupo Antonio , Capozziello Salvatore , Covone Giovanni , D’Agostino Rocco , De Laurentis Mariafelicia , De Martino Ivan , De Somma Giulia , Di Grezia Elisabetta , Di Paolo Chiara , Fatibene Lorenzo , Gammaldi Viviana , Geralico Andrea , Ingoglia Lorenzo , Lapi Andrea , Luciano Giuseppe G. , Mastrototaro Leonardo , Naddeo Adele , Pantoni Lara , Petruzziello Luciano , Piedipalumbo Ester , Pietroni Silvia , Quaranta Aniello , Rota Paolo , Sarracino Giuseppe , Sorge Francesco , Stabile Antonio , Stornaiolo Cosimo , Tedesco Antonio , Valdarnini Riccardo , Viaggiu Stefano , Yunge Andy A. V.
Published: February 2021

In Cosmology and in Fundamental Physics there is a crucial question like: where the elusive substance that we call Dark Matter is hidden in the Universe and what is it made of? that, even after 40 years from the Vera Rubin seminal discovery [1] does not have a proper answer. Actually, the more we have investigated, the more this issue has become strongly entangled with aspects that go beyond the established Quantum Physics, the Standard Model of Elementary particles and the General Relativity and related to processes like the Inflation, the accelerated expansion of the Universe and High Energy Phenomena around compact objects. Even Quantum Gravity and very exotic Dark Matter particle candidates may play a role in framing the Dark Matter mystery that seems to be accomplice of new unknown Physics. Observations and experiments have clearly indicated that the above phenomenon cannot be considered as already theoretically framed, as hoped for decades. The Special Topic to which this review belongs wants to penetrate this newly realized mystery from different angles, including that of a contamination of different fields of Physics apparently unrelated. We show with the works of this ST that this contamination is able to guide us into the required new Physics. This review wants to provide a good number of these “paths or contamination” beyond/among the three worlds above; in most of the cases, the results presented here open a direct link with the multi-scale dark matter phenomenon, enlightening some of its important aspects. Also in the remaining cases, possible interesting contacts emerges. Finally, a very complete and accurate bibliography is provided to help the reader in navigating all these issues.
Sex Differences in the Incidence and Risk Factors of Myocardial Injury in COVID-19 Patients: A Retrospective Cohort Study
Authors: Cheng Ran , Liu Chuan , Yang Jie , Yang Yuanqi , Chen Renzheng , Ding Xiaohan , Gao Xubin , Ke Jingbin , Yuan Fangzhengyuan , He Chunyan , Shen Yang , Zhang Limin , Li Ping , Tan Hu , Huang Lan
Published: February 2021

Male novel coronavirus disease (COVID-19) patients tend to have poorer clinical outcomes than female patients, while the myocardial injury is strongly associated with COVID-19-related adverse events. Owing to a lack of corresponding data, we aimed to investigate the sex differences in the incidence of myocardial injury in COVID-19 patients and to identify the potential underlying mechanisms, which may partly account for the sex bias in the incidence of adverse events. This retrospective study included 1,157 COVID-19 patients who were hospitalized in Huoshenshan Hospital from 12 March 2020 to 11 April 2020. Data on the patients’ demographic characteristics, initial symptoms, comorbidities and laboratory tests were collected. Totally, 571 (49.4%) female and 586 (50.6%) male COVID-19 patients were enrolled. The incidence of myocardial injury was higher among men than women (9.2 vs. 4.9%, p = 0.004). In the logistic regression analysis, age, and chronic kidney disease were associated with myocardial injury in both sexes. However, hypertension [odds ratio (OR) = 2.25, 95% confidence interval (CI) 1.20–4.22], coronary artery disease (OR = 2.46, 95% CI 1.14–5.34), leucocyte counts (OR = 3.13, 95% CI 1.24–7.86), hs-CRP (OR = 4.45, 95% CI 1.33–14.83), and D-dimer [OR = 3.93 (1.27–12.19), 95% CI 1.27–12.19] were independent risk factors only in the men. The correlations of hs-CRP and D-dimer with hs-cTnI and BNP were stronger in the men. The incidence of myocardial injury in COVID-19 patients is sex-dependent, predominantly in association with a greater degree of inflammation and coagulation disorders in men. Our findings can be used to improve the quality of clinical management in such settings.
Genome-Wide Analysis of the C2 Domain Family in Soybean and Identification of a Putative Abiotic Stress Response Gene GmC2-148
Authors: Sun Yue , Zhao Juan-Ying , Li Yi-Tong , Zhang Pei-Gen , Wang Shu-Ping , Guo Jun , Chen Jun , Zhou Yong-Bin , Chen Ming , Ma You-Zhi , Fang Zheng-Wu , Xu Zhao-Shi
Published: February 2021

Plant C2 domain proteins play essential biological functions in numerous plants. In this study, 180 soybean C2 domain genes were identified by screening. Phylogenetic relationship analysis revealed that C2 domain genes fell into three distinct groups with diverged gene structure and conserved functional domain. Chromosomal location analysis indicated that C2 domain genes mapped to 20 chromosomes. The transcript profiles based on RNA-seq data showed that GmC2-58, GmC2-88, and GmC2-148 had higher levels of expression under salt, drought, and abscisic acid (ABA) treatments. GmC2-148, encoding a cell membrane-localized protein, had the highest level of response to various treatments according to real-time quantitative polymerase chain reaction (RT-qPCR) analysis. Under salt and drought stresses, the soybean plants with GmC2-148 transgenic hairy roots showed delayed leaf rolling, a higher content of proline (Pro), and lower contents of H2O2, O2– and malondialdehyde (MDA) compared to those of the empty vector (EV) plants. The results of transgenic Arabidopsis in salt and drought treatments were consistent with those in soybean treatments. In addition, the soybean plants with GmC2-148 transgenic hairy roots increased transcript levels of several abiotic stress-related marker genes, including COR47, NCDE3, NAC11, WRKY13, DREB2A, MYB84, bZIP44, and KIN1 which resulted in enhanced abiotic stress tolerance in soybean. These results indicate that C2 domain genes are involved in response to salt and drought stresses, and this study provides a genome-wide analysis of the C2 domain family in soybean.
Reversals in Movement Direction in Locomotor Interception of Uniformly Moving Targets
Authors: Ceyte Gwenaelle , Casanova Remy , Bootsma Reinoud J.
Published: February 2021

Here we studied how participants steer to intercept uniformly moving targets in a virtual driving task. We tested the hypothesis that locomotor interception behavior cannot fully be explained by a strategy of nulling rate of change in pertinent agent-target relations such as the target-heading angle or target’s bearing angle. In line with a previously reported observation and model simulations, we found that, under specific combinations of initial target eccentricity and target motion direction, locomotor paths revealed reversals in movement direction. This phenomenon is not compatible with unique reliance on first-order (i.e., rate-of-change based) information in the case of uniformly moving targets. We also found that, as expected, such reversals in movement direction were not observed consistently over all trials of the same experimental condition: their presence depended on the timing of the first steering action effected by the participant, with only early steering actions leading to reversals in movement direction. These particular characteristics of the direction-reversal phenomenon demonstrated here for a locomotor interception-by-steering task correspond to those reported for lateral manual interception. Together, these findings suggest that control strategies operating in manual and locomotor interception may at least share certain characteristics.
Consequences of COVID-19 Confinement on Anxiety, Sleep and Executive Functions of Children and Adolescents in Spain
Authors: Lavigne-Cerván Rocío , Costa-López Borja , Juárez-Ruiz de Mier Rocío , Real-Fernández Marta , Sánchez-Muñoz de León Marta , Navarro-Soria Ignasi
Published: February 2021

Children and adolescents are not indifferent to the dramatic impact of the COVID-19 pandemic, and the need to be forced to live in confinement. The change in life to which they have been abruptly subjected forces us to understand the state of their mental health in order to adequately address both their present and future needs. The present study was carried out with the intention of studying the consequences of confinement on anxiety, sleep routines and executive functioning of 1,028 children and adolescents, aged from 6 to 18 years, residing in Spain to; assess if there are differences regarding these consequences in terms of sex and age; how anxiety affects executive functioning in males and females; and to examine the possible correlations between the measured variables. For this purpose, an online questionnaire containing five sections was designed: the first section gathers information on sociodemographic and health data, while the following sections gather information from different standardized scales which measure anxiety, sleep and executive functions, whose items were adapted in order to be completed by parents, and/or legal guardians. The statistical analyzes carried out highlights significant differences in executive functioning between males and females. In turn, in regards to age, greater difficulties were detected in anxiety in the 9 to 12 age group and greater sleep disturbances between 13 and 18 year olds. On the other hand, significant differences were found in intra-sexual executive functioning depending on whether they presented greater or lesser anxiety, with executive functioning being more tendentiously maladjusted in males than in females, revealing a significantly relevant effect size (p = 0.001; ω2 = 0.27 BRIEF-2; ω2 = 0.19 BDEFS-CA; 95%). Positive correlations are obtained between state anxiety and sleep and executive functioning alterations. Finally, through Path Analysis, it is verified that state anxiety is the variable with the greatest weight within the model that would explain the alteration in the executive functioning of the present sample.
Isolation and Pathogenic Characterization of Pigeon Paramyxovirus Type 1 via Different Inoculation Routes in Pigeons
Authors: Chang Han , Feng Shengyong , Wang Yutian , Li Fuhuang , Su Qianqian , Wang Bo , Du Juan , He Hongxuan
Published: February 2021

Pigeon paramyxovirus type I (PPMV-1) causes regular outbreaks in pigeons and even poses a pandemic threat among chickens and other birds. The birds infected with PPMV-1 mainly show a pathological damage in the respiratory system, digestive system, and nervous system. However, there were few reports on the efficiency of the virus entering the host via routes of different systems. In the present study, a PPMV-1 strain was obtained from a dead wild pigeon in 2016 in Beijing, China. The mean death time (MDT) and the intracerebral pathogenicity (ICPI) of our isolate showed medium virulence. Phylogenetic analysis based on F gene sequence showed that the isolate belonged to subgenotype VIb, class II, which dominated in China in recent years. Then, we evaluated the infection efficiency of different routes. Pigeons were randomly divided into five groups of six as follows: intracephalic (IC), intranasal (IN), and intraoral (IO) infection routes, cohabitation infection (CO), and negative control (N negative). All pigeons were inoculated with 100 μl·106 EID50 PPMV-1 virus. After infection, pathological lesions, virus shedding, body weight change, survival rate, and tissue tropism were tested to compare the efficiency of the different infected routes. The mortality of groups IC, IN, IO, and CO were 100, 66.7, 50, and 33.3%, respectively. Weight loss in group IC was higher than the other groups, followed by groups IN and IO. The lesions observed in PPMV-1-infected pigeons were severe, especially in the lung and intestine in group IC. Viral shedding was observed from 2 dpi in groups IC and IN, but the shedding rate was higher in group IN than group IC. The longest period was in group CO. Tissue tropism experiment showed that our isolate has a wide range of tissue distribution, and the virus titer in the heart and intestine of group IC and in the brain of group IN was higher. Our data may help us to evaluate the risk of transmission of PPMV-1.
Development, Validation, and Reliability of a Sedation Scale in Horses (EquiSed)
Authors: Oliveira Alice Rodrigues de , Gozalo-Marcilla Miguel , Ringer Simone Katja , Schauvliege Stijn , Fonseca Mariana Werneck , Trindade Pedro Henrique Esteves , Puoli Filho José Nicolau Prospero , Luna Stelio Pacca Loureiro
Published: February 2021

The lack of standardization of sedation scales in horses limits the reproducibility between different studies. This prospective, randomized, blinded, horizontal and controlled trial aimed to validate a scale for sedation in horses (EquiSed). Seven horses were treated with intravenous detomidine in low/high doses alone (DL 2.5 μg/kg + 6.25 μg/kg/h; DH 5 μg/kg +12.5 μg/kg/h) or associated with methadone (DLM and DHM, 0.2 mg/kg + 0.05 mg/kg/h) and with low (ACPL 0.02 mg/kg) or high (ACPH 0.09 mg/kg) doses of acepromazine alone. Horses were filmed at (i) baseline (ii) peak, (iii) intermediate, and (iv) end of sedation immediately before auditory, visual and pressure stimuli were applied and postural instability evaluated for another study. Videos were randomized and blindly evaluated by four evaluators in two phases with 1-month interval. Intra- and interobserver reliability of the sum of EquiSed (Intraclass correlation coefficient) ranged between 0.84–0.94 and 0.45–0.88, respectively. The criterion validity was endorsed by the high Spearman correlation between the EquiSed and visual analog (0.77), numerical rating (0.76), and simple descriptive scales (0.70), and average correlation with head height above the ground (HHAG) (−0.52). The Friedman test confirmed the EquiSed responsiveness over time. The principal component analysis showed that all items of the scale had a load factor ≥ 0.50. The item-total Spearman correlation for all items ranged from 0.3 to 0.5, and the internal consistency was good (Cronbach's α = 0.73). The area under the curve of EquiSed HHAG as a predictive diagnostic measure was 0.88. The sensitivity of the EquiSed calculated according to the cut-off point (score 7 of the sum of the EquiSed) determined by the receiver operating characteristic curve, was 96% and specificity was 83%. EquiSed has good intra- and interobserver reliabilities and is valid to evaluate tranquilization and sedation in horses.
ELEKTRONICZNY KORPUS
TEKSTÓW POLSKICH Z XVII I XVIII W.
– PROBLEMY TEORETYCZNE I WARSZTATOWE
Authors: Gruszczyński Włodzimierz , Adamiec Dorota , Bronikowska Renata , Wieczorek Aleksandra
Published: February 2021

Electronic Corpus of 17th- and 18th-century Polish Texts
– theoretical and workshop problems
Summary
This paper presents the Electronic Corpus of 17th- and 18th-century Polish
Texts (KorBa) – a large (13.5-million), annotated historical corpus available
online. Its creation was modelled on the assumptions of the National Corpus
of Polish (NKJP), yet the specifi c nature of the historical material enforced
certain modifi cations of the solutions applied in NKJP, e.g. two forms of text
representation (transliteration and transcription) were introduced, the principle
of designating foreign-language fragments was adopted, and the tagset was
adapted to the description of the grammatical structure of the Middle Polish
language. The texts collected in KorBa are diversified in chronological,
geographical, stylistic, and thematic terms although, due to e.g. limited access
to the material, the postulate of representativeness and sustainability of the
corpus was not fully implemented. The work on the corpus was to a large extent
automated as a result of using natural language processing tools.
Keywords: electronic text corpus – historical corpus – 17th-18th-century Polish
– natural language processing
Sztuka wyszukiwania w Internecie – autorski przegląd wybranych technik i narzędzi
Authors: Mider Daniel
Published: February 2021

The text consists of two parts. The first analyzed the internet search techniques – in a general heuristic sense and detailed i.e. specific techniques belonging to the family of query languages – so called operators (logical operators, localization operators, operators for communication channels in social media, chronometric operators, search operators in the content of the www and search operators for specific types of content). Their main function is to clarify search queries. The second part of the text contains a review and analysis of selected internet exploration tools – search engines (global search engines, search engines focusing on user privacy, metasearch engines and multisearch engines, regional search engines and catalogues, people search engines, search engines of gray literature and internet archives). Preview is not exhaustive or deepened, it serves rather the initial orientation of those interested in the search engine universe.
Portret wyborców AD 2019. Zmiany w preferencjach elektoratów partyjnych w Polsce
Authors: Biskup Bartłomiej
Published: February 2021

In the article profiles of polish political parties electorates in parliamentary election 2019 was analysed, as well as flows of voters and changes in voting in different sociodemographic groups. In the first part was analysed how the Poles voted in parliamentary elections 2019 by the division of different groups of electorate. In the second part was analysed flow of voters between different political parties in the parliamentary and presidential elections in 2015 and in the EU parliamentary elections in 2019 and parliamentary elections 2019.
The political and cultural factors of the new Silk Road “The Belt and Road Initiative” on the Belarusian foreign policy
Authors: Садовничий Альберт
Published: February 2021

The participation of Belarus in the Silk Road Economic Belt will bring a number of political dividends and represents a great opportunity for this country. It could led to additional investment, which is important for economic growth. China is becoming a springboard for the diversifying of the political and economic interests of Belarus, which can use this project to create a so-called security space for its sovereignty. In addition, this project is obviously aimed at deepening cultural and humanitarian cooperation. Thus, the promised benefits of Belarusian participation in this initiative seem obvious.
The Polish Senate: an unnecessary second chamber
Authors: Wieciech Tomasz
Published: February 2021

2019 marked the 30th anniversary of the restoration of the Senate in Poland. Over time its position and perception in the constitutional system has changed. From the acclaimed symbol of democratic transformation, the Senate has turned into a puzzling second chamber, with no real use. The rationale for its continued existence is becoming more and more questionable. In its current form, the Senate is an example of an unnecessary second chamber.
Antimicrobial Stewardship Programmes in Saudi Hospitals: Evidence from a National Survey
Authors: Alghamdi Saleh , Berrou Ilhem , Aslanpour Zoe , Mutlaq Alaa , Haseeb Abdul , Albanghali Mohammad , Hammad Mohamed Anwar , Shebl Nada
Published: February 2021

Saudi hospitals and healthcare facilities are facing increasing rates of antimicrobial resistance and the emergence of new multi-drug resistant strains. This is placing an unprecedented threat to successful treatments and outcomes of patients accessing those facilities. The inappropriate use of antimicrobials is fueling this crisis, warranting urgent implementation of interventions to preserve antimicrobials and reduce resistance rates. Antimicrobial stewardship programmes (ASPs) can improve antimicrobial use, treatment success rates and reduce the levels of antimicrobial resistance. The Saudi Ministry of Health (MOH) devised a national antimicrobial stewardship plan to implement ASPs in hospitals, but little is known about the progress of implementation and the factors affecting it. This study aims to assess the level and the factors affecting the adoption and implementation of ASPs in Saudi hospitals at a national level. A nationwide cross-sectional survey was conducted in 2017 using an online questionnaire sent to all MOH hospitals. Overall, 147 out 247 MOH hospitals responded to the survey (54%). Only 26% of the hospitals reported the implementation of ASPs. Hospitals lack the knowledge, technological and staff resources to adopt and implement ASPs. Alternative models of ASP adoption could be explored to improve the rates of implementation of ASPs.
A Practical and Effective Layout for a Safe Human-Robot Collaborative Assembly Task
Authors: Scimmi Leonardo Sabatino , Melchiorre Matteo , Troise Mario , Mauro Stefano , Pastorelli Stefano
Published: February 2021

This work describes a layout to carry out a demonstrative assembly task, during which a collaborative robot performs pick-and-place tasks to supply an operator the parts that he/she has to assemble. In this scenario, the robot and operator share the workspace and a real time collision avoidance algorithm is implemented to modify the planned trajectories of the robot avoiding any collision with the human worker. The movements of the operator are tracked by two Microsoft Kinect v2 sensors to overcome problems related with occlusions and poor perception of a single camera. The data obtained by the two Kinect sensors are combined and then given as input to the collision avoidance algorithm. The experimental results show the effectiveness of the collision avoidance algorithm and the significant gain in terms of task times that the highest level of human-robot collaboration can bring.
Comparisons of the Uncoupled Effects of CO2 on the CH4/O2 Counterflow Diffusion Flame under High Pressure
Authors: Chen Ying , Wang Jingfu , Zhang Xiaolei , Li Conghao
Published: February 2021

A comprehensive numerical investigation of the uncoupled chemical, thermal, and transport effects of CO2 on the temperature of CH4/O2 counterflow diffusion flame under high pressure up to 5 atm was conducted. Three pairs of artificial species were introduced to distinguish the chemical effect, thermal effect, and the transport effect of CO2 on the flame temperature. The numerical results showed that both the chemical effect and the thermal effect of the CO2 dilution in the oxidizer side can decrease the flame temperature significantly, while the transport effect of CO2 can only slightly increase the flame temperature and can even be ignored. The reduction value of the temperature caused by the chemical effect of CO2 grows linearly, while that caused by the thermal effect increases exponentially. The RPchem and RPthermal are defined to explain the temperature reduction percentage due to the chemical effect and the thermal effect of CO2 in the total temperature reduction caused by CO2 dilution, respectively. The RPchem decreases with the increase of the pressure, the strain rate, and the CO2 dilution ratio, while the RPthermal behaves in the opposite manner. In the above conditions, the chemical effect plays a dominant role on the flame temperature reduction.
Native Plant Capacity for Gentle Remediation in Heavily Polluted Mines
Authors: Jiménez María Noelia , Bacchetta Gianluigi , Navarro Francisco Bruno , Casti Mauro , Fernández-Ondoño Emilia
Published: February 2021

The use of plant species to stabilize and accumulate trace elements in contaminated soils is considered of great usefulness given the difficulty of decontaminating large areas subjected to mining for long periods. In this work, the bioaccumulation of trace elements is studied by relating the concentrations in leaves and roots of three plants of Mediterranean distribution (Dittrichia viscosa, Cistus salviifolius, Euphorbia pithyusa subsp. cupanii) with the concentrations of trace elements in contaminated and uncontaminated soils. Furthermore, in the case of D. viscosa, to know the concentration of each element by biomass, the pool of trace elements was determined both in the aerial part and in the roots. The bioaccumulation factor was not high enough in any of the species studied to be considered as phytoextractors. However, species like the ones studied in this work that live on soils with a wide range of concentration of trace elements and that develop a considerable biomass could be considered for stabilization of contaminated soils. The plant species studied in this work are good candidates for gentle-remediation options in the polluted Mediterranean.
PV-Powered Electric Vehicle Charging Stations: Preliminary Requirements and Feasibility Conditions
Authors: Cheikh-Mohamad Saleh , Sechilariu Manuela , Locment Fabrice , Krim Youssef
Published: February 2021

Environmental benefits lie in halting direct air pollution and reducing greenhouse gas emissions. In contrast to thermal vehicles, electric vehicles (EV) have zero tailpipe emissions, but their contribution in reducing global air pollution is highly dependent on the energy source they have been charged with. Thus, the energy system depicted in this paper is a photovoltaic (PV)-powered EV charging station based on a DC microgrid and includes stationary storage and public grid connection as power source backups. The goal is to identify the preliminary requirements and feasibility conditions for PV-powered EV charging stations leading to PV benefits growth. Simulation results of different scenarios prove that slow charging with long park time could increase PV benefits for EVs and may reduce the charging price, therefore, EV users should be more willing to stay at charging stations. Whereas, for fast charging, EV users should accept the high charging price since it depends on the public energy grid. Energy system distribution and EV’s energy distribution are well presented.
The Simulation of Different Combustion Stages of Micron-sized Aluminum Particles
Authors: Hu Zejun , Yang Tao , Xia Zhixun , Ma Likun , Li Mingtai , Feng Yunchao
Published: February 2021

In this study, a quasi-steady combustion model of an aluminum particle is established, which is more accurate to simulate the physical combustion process. Detailed gas-phase reaction mechanism and surface reaction mechanism are considered. Moreover, the particle temperature is not constant in this work, which is calculated in different combustion stages. The judgement standard of each combustion stage is from observational data in the experiment and the simulation results of combustion durations of each stage, and distribution of ambient temperature and gas-phase species profiles are in good agreement with experimental results. The calculation results show that in the first stage, burning rate of the particle is the fastest, and in the second stage, particle temperature can drop to more than 100 K below the boiling point for the large particles, which is slightly below the boiling point for small ones. As the combustion stage changes, Da number is going to keep going down, which will lead to the transition of combustion method from diffusion-limited control to kinetic-limited control for an aluminum particle.
Use of a Big Data Analysis in Regression of Solar Power Generation on Meteorological Variables for a Korean Solar Power Plant
Authors: Kim Young Seo , Joo Han Young , Kim Jae Wook , Jeong So Yun , Moon Joo Hyun
Published: February 2021

This study identified the meteorological variables that significantly impact the power generation of a solar power plant in Samcheonpo, Korea. To this end, multiple regression models were developed to estimate the power generation of the solar power plant with changing weather conditions. The meteorological data for the regression models were the daily data from January 2011 to December 2019. The dependent variable was the daily power generation of the solar power plant in kWh, and the independent variables were the insolation intensity during daylight hours (MJ/m2), daylight time (h), average relative humidity (%), minimum relative humidity (%), and quantity of evaporation (mm). A regression model for the entire data and 12 monthly regression models for the monthly data were constructed using R, a large data analysis software. The 12 monthly regression models estimated the solar power generation better than the entire regression model. The variables with the highest influence on solar power generation were the insolation intensity variables during daylight hours and daylight time.
Influence of the Strand Characteristics on the Properties of Oriented Strand Boards Obtained from Resinous and Broad-Leaved Fast-Growing Species
Authors: Lunguleasa Aurel , Dumitrascu Adela-Eliza , Spirchez Cosmin , Ciobanu Valentina-Doina
Published: February 2021

The paper aims to investigate the influence of the characteristics of the strands on the properties of oriented strand boards (OSB). To solve this objective, some global synthetic characteristics of the strands (the slenderness ratio, the characteristics of thinness, and the specific surface) of four wood species currently used in this technology (spruce and pine for softwood, and poplar and willow for hardwood) were first studied. The characteristics of the OSB obtained from each species separately were also determined, and finally the correlations analysis was made between the characteristics of the strands and those of the corresponding OSB boards. The working methodology used the European tests regarding the physical and mechanical properties of the boards, but also algorithms for forecasting and evaluating the quality of the strands and boards. The conclusions regarding the characteristics of the strands have highlighted the role of the specific surface of the strand and the characteristics of the thickness; respectively, the conclusions regarding the characteristics of the boards showed that the fast-growing species of willow and poplar lead to obtaining higher quality OSB boards. The general conclusion of the paper is that the characteristics of the strands have a significant influence on the physical–mechanical properties of the OSB board.
Adaptation to Other Agent’s Behavior Using Meta-Strategy Learning by Collision Avoidance Simulation
Authors: Miyamoto Kensuke , Watanabe Norifumi , Takefuji Yoshiyasu
Published: February 2021

In human’s cooperative behavior, there are two strategies: a passive behavioral strategy based on others’ behaviors and an active behavioral strategy based on the objective-first. However, it is not clear how to acquire a meta-strategy to switch those strategies. The purpose of the proposed study is to create agents with the meta-strategy and to enable complex behavioral choices with a high degree of coordination. In this study, we have experimented by using multi-agent collision avoidance simulations as an example of cooperative tasks. In the experiments, we have used reinforcement learning to obtain an active strategy and a passive strategy by rewarding the interaction with agents facing each other. Furthermore, we have examined and verified the meta-strategy in situations with opponent’s strategy switched.
Growth of Haematococcus pluvialis on a Small-Scale Angled Porous Substrate Photobioreactor for Green Stage Biomass
Authors: Do Thanh-Tri , Ong Binh-Nguyen , Le Tuan-Loc , Nguyen Thanh-Cong , Tran-Thi Bich-Huy , Thu Hien Bui Thi , Melkonian Michael , Tran Hoang-Dung
Published: February 2021

In the production of astaxanthin from Haematococcus pluvialis, the process of growing algal biomass in the vegetative green stage is an indispensable step in both suspended and immobilized cultivations. The green algal biomass is usually cultured in a suspension under a low light intensity. However, for astaxanthin accumulation, the microalgae need to be centrifuged and transferred to a new medium or culture system, a significant difficulty when upscaling astaxanthin production. In this research, a small-scale angled twin-layer porous substrate photobioreactor (TL-PSBR) was used to cultivate green stage biomass of H. pluvialis. Under low light intensities of 20–80 µmol photons m−2·s−1, algae in the biofilm consisted exclusively of non-motile vegetative cells (green palmella cells) after ten days of culturing. The optimal initial biomass density was 6.5 g·m−2, and the dry biomass productivity at a light intensity of 80 µmol photons m−2·s−1 was 6.5 g·m−2·d−1. The green stage biomass of H. pluvialis created in this small-scale angled TL-PSBR can be easily harvested and directly used as the source of material for the inoculation of a pilot-scale TL-PSBR for the production of astaxanthin.
Chemical and Optical Characteristics and Sources of PM2.5 Humic-Like Substances at Industrial and Suburban Sites in Changzhou, China
Authors: Tao Ye , Sun Ning , Li Xudong , Zhao Zhuzi , Ma Shuaishuai , Huang Hongying , Ye Zhaolian , Ge Xinlei
Published: February 2021

The chemical and optical properties and sources of atmospheric PM2.5 humic-like substances (HULIS) were investigated from October to December 2016 in both industrial and suburban areas in Changzhou, China, during polluted and fair days. The average PM2.5 concentration in the industrial region was 113.06 (±64.3) μg m−3, higher than 85.27 (±41.56) μg m−3 at the suburban site. The frequency of polluted days was significantly higher in the industrial region. In contrast, the chemical compositions of PM2.5 at the two sampling sites exhibited no statistically significant differences. Rapidly increased secondary inorganic ions (SNA = NH4+ + SO42− + NO3−) concentrations suggested secondary formation played an important role in haze formation. The daily mean concentration of humic-like substance (HULIS) was 1.8–1.9 times that of HULIS-C (the carbon content of HULIS). Our results showed that HULIS accounted for a considerable fraction of PM2.5 (industrial region: 6.3% vs. suburban region: 9.4%). There were no large differences in the mass ratios of HULIS-C/WSOC at the two sites (46% in the industrial region and 52% in the suburban region). On average, suburban HULIS-C constituted 35.1% of organic carbon (OC), higher than that (21.1%) in the industrial region. Based on different MAE (mass absorption efficiency) values under different pollution levels, we can infer that the optical properties of HULIS varied with PM levels. Moreover, our results showed no distinct difference in E2/E3 (the ratio of light absorbance at 250 nm to that at 365 nm) and AAE300–400 (Absorption Angstrom Exponent at 300–400 nm) for HULIS and WSOC. the MAE365 (MAE at 365 nm) value of HULIS-C was different under three PM2.5 levels (low: PM2.5 < 75 μg m−3, moderate: PM2.5 = 75–150 μg m−3, high: PM2.5 > 150 μg m−3), with the highest MAE365 value on polluted days in the industrial region. Strong correlations between HULIS-C and SNA revealed that HULIS might be contributed from secondary formation at both sites. In addition, good correlations between HULIS-C with K+ in the industrial region implied the importance of biomass burning to PM2.5-bound HULIS. Three common sources of HULIS-C (i.e., vehicle emissions, biomass burning, and secondary aerosols) were identified by positive matrix factorization (PMF) for both sites, but the contributions were different, with the largest contribution from biomass burning in the industrial region and secondary sources in the suburban region, respectively. The findings presented here are important in understanding PM2.5 HULIS chemistry and are valuable for future air pollution control measures.
Corticomuscular Coherence and Motor Control Adaptations after Isometric Maximal Strength Training
Authors: Elie Dimitri , Barbier Franck , Ido Ghassan , Cremoux Sylvain
Published: February 2021

Strength training (ST) induces corticomuscular adaptations leading to enhanced strength. ST alters the agonist and antagonist muscle activations, which changes the motor control, i.e., force production stability and accuracy. This study evaluated the alteration of corticomuscular communication and motor control through the quantification of corticomuscular coherence (CMC) and absolute (AE) and variable error (VE) of the force production throughout a 3 week Maximal Strength Training (MST) intervention specifically designed to strengthen ankle plantarflexion (PF). Evaluation sessions with electroencephalography, electromyography, and torque recordings were conducted pre-training, 1 week after the training initiation, then post-training. Training effect was evaluated over the maximal voluntary isometric contractions (MVIC), the submaximal torque production, AE and VE, muscle activation, and CMC changes during submaximal contractions at 20% of the initial and daily MVIC. MVIC increased significantly throughout the training completion. For submaximal contractions, agonist muscle activation decreased over time only for the initial torque level while antagonist muscle activation, AE, and VE decreased over time for each torque level. CMC remained unaltered by the MST. Our results revealed that neurophysiological adaptations are noticeable as soon as 1 week post-training. However, CMC remained unaltered by MST, suggesting that central motor adaptations may take longer to be translated into CMC alteration.
Exosomes as Emerging Biomarker Tools in Neurodegenerative and Neuropsychiatric Disorders—A Proteomics Perspective
Authors: Mathew Boby , Mansuri M. Shahid , Williams Kenneth R. , Nairn Angus C.
Published: February 2021

Exosomes are synthesized and secreted by different cell types and contain proteins, lipids, metabolites and RNA species that reflect the physiological status of the cell of origin. As such, exosomes are increasingly being used as a novel reservoir for disease biomarker discovery. However, isolation of exosomes can be challenging due to their nonuniformity of shape and variable tissue of origin. Moreover, various analytical techniques used for protein detection and quantitation remain insensitive to the low amounts of protein isolated from exosomes. Despite these challenges, techniques to improve proteomic yield and increase protein dynamic range continue to improve at a rapid rate. In this review, we highlight the importance of exosome proteomics in neurodegenerative and neuropsychiatric disorders and the associated technical difficulties. Furthermore, current progress and technological advancements in exosome proteomics research are discussed with an emphasis on disease-associated protein biomarkers.
Self-Positivity or Self-Negativity as a Function of the Medial Prefrontal Cortex
Authors: Yankouskaya Alla , Sui Jie
Published: February 2021

Self and emotions are key motivational factors of a person strivings for health and well-being. Understanding neural mechanisms supporting the relationship between these factors bear far-reaching implications for mental health disorders. Recent work indicates a substantial overlap between self-relevant and emotion information processing and has proposed the medial prefrontal cortex (MPFC) as one shared neural signature. However, the precise cognitive and neural mechanisms represented by the MPFC in investigations of self- and emotion-related processing are largely unknown. Here we examined whether the neural underpinnings of self-related processing in the MPFC link to positive or negative emotions. We collected fMRI data to test the distinct and shared neural circuits of self- and emotion-related processing while participants performed personal (self, friend, or stranger) and emotion (happy, sad, or neutral) associative matching tasks. By exploiting tight control over the factors that determine the effects of self-relevance and emotions (positive: Happy vs. neutral; negative: Sad vs. neutral), our univariate analysis revealed that the ventral part of the MPFC (vmPFC), which has established involvement in self-prioritisation effects, was not recruited in the negative emotion prioritisation effect. In contrast, there were no differences in brain activity between the effects of positive emotion- and self-prioritisation. These results were replicated by both region of interest (ROI)-based analysis in the vmPFC and the seed- to voxel functional connectivity analysis between the MPFC and the rest of the brain. The results suggest that the prioritisation effects for self and positive emotions are tightly linked together, and the MPFC plays a large role in discriminating between positive and negative emotions in relation to self-relevance.
Prognostic Gene Expression, Stemness and Immune Microenvironment in Pediatric Tumors
Authors: Stahl David , Knoll Rainer , Gentles Andrew J. , Vokuhl Christian , Buness Andreas , Gütgemann Ines
Published: February 2021

Pediatric tumors frequently arise from embryonal cells, often displaying a stem cell-like (“small round blue”) morphology in tissue sections. Because recently “stemness” has been associated with a poor immune response in tumors, we investigated the association of prognostic gene expression, stemness and the immune microenvironment systematically using transcriptomes of 4068 tumors occurring mostly at the pediatric and young adult age. While the prognostic landscape of gene expression (PRECOG) and infiltrating immune cell types (CIBERSORT) is similar to that of tumor entities occurring mainly in adults, the patterns are distinct for each diagnostic entity. A high stemness score (mRNAsi) correlates with clinical and morphologic subtype in Wilms tumors, neuroblastomas, synovial sarcomas, atypical teratoid rhabdoid tumors and germ cell tumors. In neuroblastomas, a high mRNAsi is associated with shortened overall survival. In Wilms tumors a high mRNAsi correlates with blastemal morphology, whereas tumors with predominant epithelial or stromal differentiation have a low mRNAsi and a high percentage of M2 type macrophages. This could be validated in Wilms tumor tissue (n = 78). Here, blastemal areas are low in M2 macrophage infiltrates, while nearby stromal differentiated areas contain abundant M2 macrophages, suggesting local microanatomic regulation of the immune response.
Association between Immune Related Adverse Events and Outcome in Patients with Metastatic Renal Cell Carcinoma Treated with Immune Checkpoint Inhibitors
Authors: Paderi Agnese , Giorgione Roberta , Giommoni Elisa , Mela Marinella , Rossi Virginia , Doni Laura , Minervini Andrea , Carini Marco , Pillozzi Serena , Antonuzzo Lorenzo
Published: February 2021

Background: It has been reported that the occurrence of immune-related adverse events (irAEs) in oncological patients treated with immune-checkpoint inhibitors (ICIs) may be associated with favorable clinical outcome. We reported the clinical correlation between irAEs and the efficacy of ICIs in a real-world cohort of metastatic renal cell cancer (mRCC) patients. Methods: We retrospectively evaluated 43 patients with mRCC who were treated with nivolumab or with nivolumab plus ipilimumab. We considered seven specific classes of irAEs including pulmonary, hepatic, gastrointestinal, cutaneous, endocrine, rheumatological, and renal manifestations. We assessed progression-free survival (PFS) of specific irAEs classes compared to the no-irAEs group. Results: Twenty-nine out of 43 patients (67.4%) experienced a total of 49 irAEs registered. The most frequent irAE was thyroid dysfunction (n = 14). The median PFS after the beginning of therapy was significantly longer in patients with thyroid dysfunction and cutaneous reactions. In multivariate analysis, thyroid dysfunction was an independent factor for favorable outcome [HR: 0.29 (95% CI 0.11–0.77) p = 0.013]. Moreover, experiencing ≥2 irAEs in the same patient correlated in multivariate analysis with better outcome compared with none/one irAE [HR: 0.33 (95% CI 0.13–0.84) p = 0.020]. Conclusions: This retrospective study suggests an association between specific irAES (thyroid dysfunction and skin reaction) and efficacy of ICIs in metastatic RCC. Notably, multiple irAEs in a single patient were associated with better tumor response.