bluuebunny/crossref_metadata_2025 huggingface dataset:
Systemic vasculopathy associated with an RNF213 p.Arg4810Lys variant in moyamoya disease: A review
Authors: Kim Duk-Kyung , Jang Shin Yi , Chang Sung-A , Park Taek Kyu
Published: August 2022

Moyamoya disease (MMD) is a steno-occlusive disease of the distal cerebral arteries. Ring finger protein 213 (RNF213) p.Arg4810Lys is a susceptibility gene of MMD for which related vasculopathies are not well characterized. Heterozygous patients were mostly asymptomatic or exhibited isolated MMD. Homozygous patients showed a very unique pattern of diffuse narrowing of the entire aorta along with stenosis of the splanchnic, renal, coronary, iliofemoral, and/or peripheral pulmonary arteries, regardless of presence or absence of MMD. RNF213 p.Arg4810Lys is associated with high penetrance of systemic vasculopathy in homozygous patients and low penetrance of intracranial stenosis, i.e., MMD, in heterozygous patients, which suggests a gene-dosage effect.
Re-examining Indonesia’s Nickel Export Ban: Does it Violate the Prohibition to Quantitative Restriction?
Authors: Dewi Yetty , Mikaila Jessy Azzahra
Published: August 2022

The fundamental principles adopted by the WTO are free trade and trade liberalization, realized through the reduction of trade barriers like quantitative restrictions. This paper examines the parameters of a measure that can be construed as a quantitative restriction in violation of WTO law. It also examines whether Indonesia’s measures in prohibiting the export of nickel ores and imposing domestic processing requirements violate WTO law. The statutory and case study approaches were used to determine and analyze Indonesia’s measures. The parameter for quantitative restriction is imposed in Article XI: I of the GATT 1994. The parameter warrants that a measure shall be in the form of prohibitions or restrictions apart from duties, taxes, or charges. The measure must also be enacted through quotas, import or export licenses, or other measures such as import or export prohibitions. Finally, the nature of the measure must be limited in amounts. However, a measure that fulfills such parameters may not violate WTO law if it is justified under exclusionary articles under the GATT 1994. The paper concludes that Indonesia’s measures above constitute quantitative restrictions, as they fulfill the parameters above. However, there is a possibility that the measures may not violate WTO law. This is because the measures also fulfil the parameters of justifications under Article XX (g) of the GATT 1994 on general exceptions and to a lesser extent under Article XI: (2)(a) of the GATT 1994 on the exception to quantitative restrictions.
Utilization of Plastic Waste as Paver Block, Economic Potential, and Environmental Impact
Authors: Rachmawati Lulu Millatina , Avianto Luthfi Wigi , Mubarak Luthfi Rizqi , Rasyid Tazlila Rahmi , Suwandi Suwandi , Suprayogi Suprayogi , Utami Amaliyah Rohsari Indah , Chandra Indra
Published: August 2022

One of the main factors that cause environmental damage in Indonesia is waste. Reducing waste by burning it directly without an incinerator will cause air pollution for the environment. CO2 is a substance produced by a complete combustion process. The amount of waste produced by Bandung Regency reaches 1,480.1 tons/day, with 20% of the waste being plastic waste. One way to utilize plastic waste is to recycle it into materials to produce paver blocks. Producing paver blocks requires a series of machines, such as crushing machines, plastic melting machines, and pressing machines. Plastic waste that has been sorted is put into a chopping machine and cut into 10 mm pieces. The plastic that has been cut is then melted down and printed, then re-pressed with a press machine. The type of plastic used in this research is polypropylene, with a melting point of 160-170°C. The size of the paver block produced is compatible with the market size. During the production of paver blocks, the CO2 concentration was monitored to see the effect of resin melting. In the analysis of paver blocks' economic potential, we found that the production cost using plastic waste is relatively expensive compared to conventional paver blocks. However, this type of paver block is not harmful to the environment. The results of this study indicate that plastic waste paver blocks can be used as paver block materials because they have quite an impact on the environment, although their economic value cannot compete with conventional paver blocks.
Analysis of the Effect of Current Ratio, Debt to Equity Ratio, Total Asset Turnover and Return on Equity Towards Profit Planning at PT Mina Mulia Perkasa
Authors: Ardian Noni
Published: August 2022

The more effective the profit planning, the greater the company's net profit. High profit planning demonstrates the company's ability to create value for its shareholders. The company's success in developing this value undoubtedly results in increased profits for its stockholders. This return is extremely important since it is used as a measure of the company's performance and as a basis for evaluating the future returns associated with expectations and risks. This study aimed to investigate and analyze the impact of CR on profits planning. To examine and assess the influence of DER on profit planning. To examine and assess TATO's impact on profit planning. To evaluate and analyze the impact of ROE on profit planning in the catering industry. To evaluate and assess the impact of CR, DER, TATO, and ROE on profit planning. This study employs quantitative data analysis, which involves testing and analyzing data by calculating numbers, followed by drawing conclusions from the test using descriptive statistical tests and multiple correlations. However, the data processing for this study is not performed manually, but rather through the use of Statistical Product and Service Solutions (SPSS). According to the study's findings, CR, TATO, DER, and ROE have a considerable influence on profit planning, both partially and simultaneously
Advokasi dan Negosiasi: Diplomasi Hak Asasi Manusia Republik Korea Masa Pada Masa Park Geun-hye Mengenai Comfort Women
Authors: Ibrahim Muhammad Pratama Putra , Rezasyah Teuku
Published: August 2022

Usaha diplomasi yang dilaksanakan pemerintahan Park Geunhye untuk menangani persoalan comfort women adalah merupakan penerapan dari putusan Mahkamah Konstitusi Republik Korea tahun 2011 mengenai comfort women. Artikel ini berupaya mendeskripsikan bagaimana diplomasi ini dijalankan melalui konsep diplomasi hak asasi manusia yang terdiri atas dua proses, yakni negosiasi dan advokasi. Pemerintah Republik Korea melalui usaha negosiasinya dengan Jepang mengadakan pertemuan tingkat direktur jenderal dan pembicaraan tingkat tinggi. Dalam hal ini, ditemukan bahwa keseluruhan empat elemen negosiasi klasik diplomasi hak asasi manusia menurut Archer berhasil dipenuhi. Dengan catatan bahwa elemen keempat tidak 2 menghasilkan suatu luaran yang terbuka, melainkan suatu kesepakatan yang spesifik. Dalam usaha advokasinya, pemerintah Republik Korea menggunakan taktik naming and shaming dan fokus tematik dalam mengangkat empat tema besar Jepang sebagai pelaku pelanggaran hak asasi manusia terhadap comfort women: pertama, kejahatan kemanusiaan; kedua, perbudakan seksual militer; ketiga, Pernyataan Kono; keempat, reputasi internasional Jepang. Kedua proses ini dilaksanakan sejak dilantiknya Park Geun-hye pada Februari 2013 hingga akhir Desember 2015 dan dilakukan secara bersamaan.
Dukungan Indonesia Africa Infrastructure Dialogue 2019 terhadap Diplomasi Korporasi Indomie di Nigeria
Authors: Parningotan Harold Yehezkiel Prasetyo , Sari Viani Puspita
Published: August 2022

Indomie sebagai salah satu produk Indonesia merupakan produk dari PT. Indofood Sukses Makmur TBK. Kepopuleran Indomie terlihat hingga di berbagai negara, salah satunya adalah Nigeria. Indomie di Nigeria sangat popular berkat usaha salah satu pihak relasi Indofood, Dufil melalui Diplomasi Korporasi, yang bertujuan untuk mendukung potensi pasar Indomie di Nigeria hingga benua Afrika. Diplomasi Indonesia terhadap benua Afrika Indonesia Africa Infrastructure Dialogue 2019¸berfokus kepada diplomasi ekonomi dalam  investasi dan perdagangan di sektor infrastruktur dan sektor potensial di Afrika. Penelitian tersebut bertujuan untuk memahami  dukungan pemerintah Indonesia melalui Indonesia Africa Infrastructure Dialogue 2019 terhadap Diplomasi Korporasi Indomie di  Nigeria pada tahun 2018 – 2020 yang dapat mengembangkan pasar Indomie di Nigeria hingga benua Afrika. Penelitian tersebut akan dilihat melalui pendekatan neoliberalisme dan teori diplomasi korporasi dengan menggunakan metode kualitatif dengan pendekatan empiris dapat menjelaskan fenomena tersbeut yang didukung oleh berbagai data baik studi literatur dan hasil wawancara.
Diplomasi Ekonomi Indonesia ke Bangladesh: Studi Kasus Ekspor Gerbong Kereta
Authors: Denura Jihan Salsabila , Sari Viani Puspita
Published: August 2022

Diplomasi ekonomi ialah prioritas kebijakan luar negeri Indonesia periode 2014-2019. Diplomasi ekonomi ini difokuskan untuk pasar non-tradisional Indonesia yaitu kawasan Afrika, Amerika Latin, Timur Tengah, Asia Tengah dan asia Selatan. Riset ini akan menyoroti diplomasi ekonomi Indonesia di Bangladesh dalam studi kasus ekspor gerbong kereta. Pada tahun 2017, PT INKA memenangkan tender pengadaan 250 gerbong kereta di Bangladesh mengalahkan Tiongkok dan India. Riset ini bertujuan untuk mengetahui bagaimana diplomasi ekonomi Indonesia berperan dalam keberhasilan ekspor di pasar non-tradisional yaitu Bangladesh. Riset ini menggunakan pendekatan diplomasi dan diplomasi ekonomi sebagai pisau analisis dan meminjam konsep diplomasi ekonomi Okano-Heijmans. Metode riset yang digunakan ialah metode riset kualitatif dengan teknik pengumpulan data primer, sekunder dan wawancara. Temuan riset ini ialah diplomasi ekonomi Indonesia utamanya berperan dalam proses penawaran tender yang diikuti PT INKA dengan cara memberikan fasilitas kemudahan pajak dan pembiayaan Eximbank agar PT INKA dapat bersaing secara kompetitif dengan kompetitor lainnya di pasar yang sangat sensitive terhadap harga. Diplomasi ekonomi ini juga melibatkan berbagai aktor negara dan non-negara yaitu Kementerian Luar Negeri, Kementerian Keuangan, PT INKA, Biswas Construction dan Eximbank Indonesia. Diplomasi ekonomi Indonesia ke Bangladesh menghasilkan sebuah kesepakatan yang memenuhi balance of interest.
Pelaksanaan ASEAN Single Aviation Market dalam Industri Penerbangan di Indonesia
Authors: Maulana Aldy Akbar , Sidik Hasan , Sari Deasy Silvya
Published: August 2022

Penelitian ini bertujuan untuk mengetahui pelaksanaan ASAM dalam industri penerbangan di Indonesia. Penulis menggunakan metode kualitatif untuk menganalisis secara mendalam terkait fenomena yang terjadi. Sumber data berasal dari document-based research berupa dokumen resmi, wawancara dengan narasumber, dan internet-based research berupa buku, jurnal, berita, maupun sumber rujukan lain dari internet. Periset menggunakan teori rezim internasional untuk melihat karakteristik rezim di dalam ASAM dan memasukannya ke dalam skema pendekatan conventional structuralism untuk melihat perkembangan implementasi rezim di Indonesia. Artikel ini menunjukkan bahwa ASAM telah memenuhi karakteristik rezim internasional di ASEAN, terlihat dari prinsip, norma, dan aturan prosedur yang membentuk rezim. ASAM menjadi sebuah komitmen jangka panjang untuk melalukan integrasi kawasan melalui liberalisasi penerbangan. Namun, pembentukan hingga pengaplikasian ASAM masih didasarkan pada kepentingan negara. Kebijakan ASAM di Indonesia masih terdapat proteksionisme terhadap pelaksanaannya. Pelaksanaan ASAM di Indonesia hanya diterapkan pada penerbangan internasional. Sedangkan penerbangan domestik masih mempertahankan prinsip cabotage.
Diplomasi Perdagangan Indonesia di Afrika Selatan (2015-2019): Upaya Peningkatan Perdagangan di Pasar Afrika Selatan
Authors: Febrianti Sekar Wulan , Suryadipura Dadan
Published: August 2022

Riset ini dibuat untuk mengetahui upaya diplomasi perdagangan Indonesia dalam meningkatkan perdagangannya di Afrika Selatan tahun 2015-2019. Komsep yag digunakan adalah konsep diplomasi perdagangan dari Okano Heijmans. Metode yang digunakan dalam riset ini adalah metode kualitatif dengan pendekatan interpetif. Sumber data berasal dari studi pustaka dan wawancara dengan narasumber terkait. Hasil riset menunjukkan bahwa Indonesa melakukan beberapa aktivitas diplomasi perdagangan di Afrika Selatan seperti mengupayakan penurunan tariff melalui pembentukan PTA bersama SACU dan Afrika Selatan, membuat Konsultasi Bilateral RI-Afrika Selatan, melakukan kunjungan terkait pendirian pabrik Indomie di Afrika Selatan, serta melindungi produk Indonesia dari anti dumping dan safeguard. Dari upaya yang dilakukan, upaya pembentukan PTA belum dapat dilakukan. Hambatan utama dalam meningkatkan perdagangan Indonesia di Afrika Selatan adalah tariff yang tinggi serta masih rendahnya rasa percaya Afrika Selatan terhadap Indonesia sebagai mitra dagang. Untuk meningkatkan perdagangan, selain melakukan diplomasi perdagangan, Indonesia dapat masuk ke pasar Afrika Selatan melalui investasi, joint venture, dan promosi  perdagangan.    Diplomasi Ekonomi, Diplomasi Perdagangan, Ekspor, TariffRiset ini dibuat untuk mengetahui upaya diplomasi perdagangan Indonesia dalam meningkatkan perdagangannya di Afrika Selatan tahun 2015-2019. Komsep yag digunakan adalah konsep diplomasi perdagangan dari Okano Heijmans. Metode yang digunakan dalam riset ini adalah metode kualitatif dengan pendekatan interpetif. Sumber data berasal dari studi pustaka dan wawancara dengan narasumber terkait. Hasil riset menunjukkan bahwa Indonesa melakukan beberapa aktivitas diplomasi perdagangan di Afrika Selatan seperti mengupayakan penurunan tariff melalui pembentukan PTA bersama SACU dan Afrika Selatan, membuat Konsultasi Bilateral   RI-Afrika   Selatan,   melakukan   kunjungan  terkaitpendirian pabrik Indomie di Afrika Selatan, serta melindungi produk Indonesia dari anti dumping dan safeguard. Dariupaya yang dilakukan, upaya pembentukan PTA belum dapat dilakukan. Hambatan utama dalam meningkatkan perdagangan Indonesia di Afrika Selatan adalah tariff yang tinggi serta masih rendahnya rasa percaya Afrika Selatan terhadap Indonesia sebagai mitra dagang. Untuk meningkatkan perdagangan, selain melakukan diplomasi perdagangan, Indonesia dapat masuk ke pasar Afrika Selatan melalui investasi, joint venture, dan promosiperdagangan.
Ensino remoto emergencial sob a perspectiva discente
Authors: Marinho Raimunda , Santos Adenilze  Dias dos
Published: August 2022

O texto discorre sobre como a tecnologia faz parte do processo de ensino sob o ponto de vista dos alunos, de modo a estabelecer ressignificações do mundo digital. Figuram como objetivos específicos conhecer os dispositivos, plataformas e estratégias tecnológicas que os alunos da educação superior utilizam no processo ensino aprendizagem, bom como discutir implicações e os desdobramentos de aprendizagem mediada por tecnologias móveis produz nos alunos vinculados aos cursos de graduação. Procedimentos metodológicos se caracterizam como estudo exploratório, cujo levantamento junto aos alunos. Na coleta de dados foi utilizado o questionário online, desenvolvido na plataforma Google Forms com questões de múltipla escolha. Conclui-se, pela necessidade do estabelecimento de uma política, pela universidade, de aprimoramento de conhecimentos técnicos e teóricos não recebidos devido ao formato de ensino remoto adotado.
O design thinking como metodologia para o planejamento de ações em letramento informacional
Authors: Ribeiro Menezes Matheus , Boaventura Sales paixão Pablo
Published: August 2022

O Design Thinking é uma ferramenta ampla que pode ser aplicada nos mais diversos campos dentre eles a Ciência da Informação. A problemática que dá origem a este estudo parte da seguinte premissa: como o Design Thinking pode subsidiar o planejamento de ações voltadas para o processo de Letramento Informacional? O presente trabalho busca demonstrar como Design Thinking pode auxiliar na aplicação e consolidação de ações que fomentem habilidades e competências necessárias para o desenvolvimento do processo do Letramento Informacional. A metodologia aqui estudada é oriunda de pesquisas bibliográficas nas áreas da Ciência da Informação, através do Letramento Informacional, e na área do Design, através do Design Thinking. O estudo observou que o Design Thinking, a partir de sua metodologia própria, pode contribuir para o desenvolvimento de ações de Letramento Informacional a partir do pensamento coletivo dos sujeitos criadores dessas ações de intervenção voltadas para o desenvolvimento do Letramento Informacional.
Educação de usuários na Ciência da Informação
Authors: Silva Kleisson Lainnon Nascimento , Franklin Kleane Pâmela dos Santos , Vasconcelos Daniel Henriques
Published: August 2022

O presente estudo objetiva identificar e analisar publicações disponibilizadas na Base de Dados de Artigos de Periódicos de Ciência da Informação, caracterizando-se como descritivo, documental, de natureza quantitativa, utilizando-se das inferências de estatística descritiva e da análise de redes sociais. Para consecução deste objetivo, recorre-se ao uso do descritor “educação de usuários”, resultando em 27 artigos. Para análise dos dados, empregou-se o método bibliométrico, através do qual verificou-se que a ocorrência de estudos se deu entre 1981 e 2021, apresentando lacunas teóricas em determinados períodos, ostentando a partir de 2012 fluxo de divulgação corrente, em níveis alternantes, com maior incidência em 2018 (n=6) e 2019 (n=4). Dos 53 autores localizados, Silva, J., Freire, G. e Almeida, J. se qualificam como os mais produtivos. Constatou-se ainda, que o periódico científico se apresenta como veículo de comunicação científica oficial, ostentando, de modo geral 23 (85%) da produção sobre a temática, enquanto quatro (15%) compreende artigos publicados nos anais do Encontro Nacional de Pesquisa e Pós-Graduação em Ciência da Informação. Portanto, a partir desta pesquisa verificou-se que o tema educação de usuários na Ciência da Informação, demonstra-se pouco discutido e abordado, a partir da qual sinaliza-se a necessidade de produção e sugestões de outras pesquisas.
Ética na produção e compartilhamento da informação
Authors: Farias Mayara Wasty Nascimento de
Published: August 2022

O desenvolvimento das Tecnologias Digitais de Informação e Comunicação possibilitou uma nova perspectiva à sociedade. As formas de produção, compartilhamento e uso da informação foram alteradas e neste novo cenário o usuário figura como protagonista e media a informação transmitida. Mais que isso, pode influenciar na formação de conhecimento de outros usuários.  Apesar de inúmeros benefícios oriundos das tecnologias digitais, esse novo cenário amplia as possibilidades das desordens informacionais. No ambiente virtual os conteúdos disponibilizados são criados e circulam sem monitoramento, possibilitando a desinformação. Neste sentido, o artigo traz uma reflexão sobre a ética da informação relacionada ao fenômeno da fake news e cultura da pós-verdade. Com o trabalho, pretende-se debater sobre esta problemática informacional emergente nos últimos anos sob a ótica do campo da Ciência da Informação e identificar iniciativas que buscam combater a desinformação. A pesquisa é classificada como bibliográfica por trazer conceitos da área e qualitativa por apresentar análise crítica sobre a problemática em questão. Desta forma, conclui-se a web configura-se como maior sistema de publicação do mundo e que sua arquitetura aberta possibilita o compartilhamento de notícias falsas. Ainda assim, entende-se que a disseminação dessas informações incorretas está ligada a fatores relacionados à pós-verdade: crenças pessoais, conforto psicológico e/ou ganho pessoal. Neste cenário, a ética pessoal dos usuários ganha cada vez mais importância na sociedade.
Estudo da percepção de estudantes universitários sobre o plágio acadêmico
Authors: Batista Daniela Santos , Costa Renata Ferreira
Published: August 2022

Tendo em vista o conceito de plágio como a apropriação ou expropriação de direitos autorais, questiona-se a ideia de autoria em uma sociedade amplamente digital, marcada pelo produtivismo, cuja quantidade, qualidade e reconhecimento das pesquisas realizadas e publicadas no ambiente acadêmico envolvem muitas vezes infrações éticas. Desta forma, o presente artigo tem como objetivo principal apresentar os resultados alcançados em uma pesquisa realizada em 2019 sobre a percepção dos estudantes de graduação inseridos em programas de Iniciação Científica e de Pós-graduação da Universidade Federal de Sergipe (UFS) sobre o Plágio Acadêmico, sendo este um debate atual e necessário, que vem sendo amplamente discutido no cenário acadêmico mundial, mas que, mesmo com avanços consideráveis, ainda é lacunar no âmbito nacional. A pesquisa realizada, de cunho exploratório-descritivo, baseou-se em uma amostragem por conveniência e considerou como instrumento de pesquisa a aplicação de um questionário on-line, por meio da plataforma Google Formulários. A partir dos resultados obtidos, constatou-se que graduandos que fazem iniciação científica e pós-graduandos da UFS possuem poucas e superficiais noções sobre o plágio, sobretudo do ponto de vista teórico e conceitual, desconhecendo suas especificidades, formas de manifestação e a legislação ou documentos vigentes e norteadores sobre esse fenômeno. Ainda que essa seja uma temática recorrente na atualidade em diversos espaços, ainda há incertezas sobre uma prática tão nociva à propriedade intelectual e à integridade científica, que interfere na construção do conhecimento através da pesquisa especializada.
Phenotypic performance of new pro-vitamin A maize (Zea mays L.) hybrids using three selection indices
Authors: Kolawole Adesike Oladoyin , Olayinka Abiodun Fatai
Published: August 2022

The development of new bio-fortified maize hybrids is crucial for achieving food security and alleviation of micronutrient deficiencies. This study aims at assessing the performance of new pro-vitamin A maize hybrids and identifying potential high-yielding hybrids using base index, multivariate selection index, and rank summation index. Twenty-four pro-vitamin A maize hybrids and one hybrid check were evaluated in the rainy seasons of 2018 and 2019 at Ladoke Akintola University of Technology Teaching and Research farm in Ogbomoso, Nigeria. Hybrids were planted each year in a 5 × 5 α lattice design with three replications. Data collected on grain yield and agronomic traits were analysed. The hybrids showed significant (P < 0.001) variations for all measured traits except plant aspect and maize streak virus scores. The mean grain yield of hybrids over two years varied from 1,106 kg/ha (LY 1312-12) to 5,144 kg/ha (LY 1501-9). The highest yielding hybrid across the years had a 31% yield advantage over the single-cross hybrid used as a check. The base index had the highest selection differential (34%) for grain yield. The rank summation index had a strong correlation with the multivariate selection index (r = ‒0.86+++) followed by base index (r = ‒0.56+++). The three selection indices used identified three superior three-way cross hybrids (LY 1409-21, LY 1501-9 and LY 1501-1) with a slight change in rank order. These outstanding hybrids which combine high productivity with nutrients may be considered for advanced multi-location and on-farm testing before their release to farmers in derived savanna agroecology of Nigeria.
Compressive Loading of Apple Cultivar Golden Delicious
Authors: Kubík Ľubomír , Kažimírová Viera , Božiková Monika
Published: August 2022

The study dealt with the experimental and numerical assessment of the apple cultivar Golden Delicious (Malus domestica L.) at compressive loading in lateral direction. The development of fruit hemisphere behaviour was examined between two parallel plates. Apple samples were subjected to tests at different strain rates. The experiments were conducted at eleven velocities from 10 to 350 mm·min−1 for the purposes of achieving different strain rates. Compression tests of the fruits at different strain rates corresponded to the quasi-state loading. Impacts of loading rate and strain rate on force and stress at compression were studied. The material exhibited nonlinear behaviour of dependency of stresses on strains, but linear viscoelastic behaviour of dependency of stresses on strain rate. The application possibilities of Kelvin-Voight viscoelastic model were evaluated. Forces, strains, stresses and the apparent moduli of elasticity were evaluated for the detection of fruit damage at different strain rates.
U-Net architecture variants for brain tumor segmentation of histogram corrected images
Authors: Lefkovits Szidónia , Lefkovits László
Published: August 2022

In this paper we propose to create an end-to-end brain tumor segmentation system that applies three variants of the well-known U-Net convolutional neural networks. In our results we obtain and analyse the detection performances of U-Net, VGG16-UNet and ResNet-UNet on the BraTS2020 training dataset. Further, we inspect the behavior of the ensemble model obtained as the weighted response of the three CNN models. We introduce essential preprocessing and post-processing steps so as to improve the detection performances. The original images were corrected and the different intensity ranges were transformed into the 8-bit grayscale domain to uniformize the tissue intensities, while preserving the original histogram shapes. For post-processing we apply region connectedness onto the whole tumor and conversion of background pixels into necrosis inside the whole tumor. As a result, we present the Dice scores of our system obtained for WT (whole tumor), TC (tumor core) and ET (enhanced tumor) on the BraTS2020 training dataset.
Transmission-reciprocal transmission index and coindex of graphs
Authors: Ramane Harishchandra S. , Kitturmath Deepa V. , Bhajantri Kavita
Published: August 2022

The transmission of a vertex u in a connected graph G is defined as σ(u) = Σv∈V(G) d(u, v) and reciprocal transmission of a vertex u is defined as

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rs(u) = \sum\nolimits_{v \in V\left( G \right)} {{1 \over {d\left( {u,v} \right)}}}

, where d(u, v) is the distance between vertex u and v in G. In this paper we define new distance based topological index of a connected graph G called transmission-reciprocal transmission index

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TRT\left( G \right) = \sum\nolimits_{uv \in E\left( G \right)} {\left( {{{\sigma \left( u \right)} \over {rs\left( u \right)}} + {{\sigma \left( v \right)} \over {rs\left( v \right)}}} \right)}

and its coindex

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\overline {TRT} \left( G \right) = \sum\nolimits_{uv \notin E\left( G \right)} {\left( {{{\sigma \left( u \right)} \over {rs\left( u \right)}} + {{\sigma \left( v \right)} \over {rs\left( v \right)}}} \right)}

, where E(G) is the edge set of a graph G and establish the relation between TRT(G) and

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(G). Further compute this index for some standard class of graphs and obtain bounds for it.
The organizational, economic, and marketing research of pharmacy activities in extemporaneous compounding of drugs
Authors: Samborsky O. S.
Published: August 2022

Aim. To conduct a complex organizational, economic, and marketing study of the work of a pharmacy with extemporaneous compounding of drugs.Materials and methods. The research materials were scientific publications in periodicals, reporting data on economic and financial activities of the pharmacy. General scientific and special methods, such as system analysis, historical, analytical, economic, marketing research modeling, were used in the work. The calculation of the cost of “Una” paste, calculation of profitability, determination of the break-even point and modeling of options for the flow of discounted income from the sale of the paste were carried out according to the computer processing described in the guidelines approved by the Ukrainian Center for Scientific Medical Information and Patent Licensing Works of the Ministry of Health of Ukraine.Results. The main financial and economic indicators of the work of the pharmacy with extemporaneous compounding of drugs were analyzed. The low profitability of work of the Department of OTC Drugs and Prescription and Production Department was determined; it was 2.31 and 17.77 %, respectively. It was found that the conditional fixed costs of the Prescription and Production Department amounted to UAH 76420.60 in 2021, and 0.15 UAH of conditional fixed costs was accounted per 1.00 UAH of manufactured products. The method for determining the cost price, price and profitability for extemporaneous products on the example of “Una” paste was developed, and the components of added value were determined. Computermodeling of possible financial flows for the sale of “Una” paste based on three market events (the most likely, optimistic and pessimistic options) was carried out. Changes in the break-even point and the profitability level at different prices were shown. It was determined that the price of “Una” paste for a package of 52 UAH would bring the profitability of the product to the level of 40.04 %, and the share of profit in the added value to 52.43 %.Conclusions. Based on the results of the analysis of the main financial and economic indicators of the work of the pharmacy, it has been found that the profitability indicators of the Department of OTC Drugs and Prescription and Production Department are at low levels. The profitability of certain types of dosage forms and cosmetic products has been calculated. The economic analysis of determining the cost price and the price of products on the example of “Una” paste has been developed. Using mathematical modeling, the break-even point of “Una” paste and financial flows in three variants of possible market events (the most likely, optimistic and pessimistic) have been determined. The price of “Una” paste has been set, at which the optimal level of profitability of 40 % will be achieved.Key words: profitability; economic indicators; assortment of products; extemporaneous compoundingof drugs; pharmacy.
Monitoring of the psychosocial climate state in the personnel management system of a pharmacy institution
Authors: Andriienko N. V. , Sahaidak-Nikitiuk R. V.
Published: August 2022

Aim. To develop a program for monitoring the psychosocial climate state in the personnel management system of a pharmacy institution.Materials and methods. The study used the methods of generalization, analysis and synthesis, content analysis and questionnaires. The state of the psychosocial climate in the pharmacy was determined using a diagnostic questionnaire of the psychosocial climate in the group. Assessments of the emotional, cognitive and behavioral components of the psychosocial climate in the pharmacy workforce were ranged from -1 to +1. The psychometric test of C. E. Seashore was used to assess group cohesion. 571 People from 167 pharmacies took part in the survey. According to the validation results, the representative sample is 563 pharmacists. The study covered all regions of Ukraine: Kharkiv (23.1 % of respondents), Poltava (17.4 % of respondents), Vinnytsia (4.9 % of respondents), Sumy (14.2 % of respondents), Zaporizhzhya (13.3 % of respondents), Ternopil (5.6 % of respondents), Zhytomyr (3.9 % of respondents), Rivne (7.1 % of respondents), Lviv (5.7 % of respondents), Ivano-Frankivsk (2.9 % of respondents) and Khmelnytskyi (1.9 % of respondents) regions of Ukraine. 92.7 % of respondents have a higher education, 7.3 % have a professional pre-higher education. According to their work experience, respondents are divided as follows: up to 1 year – 5.4 % of respondents, from 1 year to 5 years – 13.9 % of respondents, from 5 to 10 years – 18.3 %of respondents, from 10 to 20 years – 35.5 % of respondents, over 20 years – 26.9 % of respondents.Results. The necessity of managing the psychosocial climate in a pharmacy workforce and its monitoring has been proven. The essence of the psychosocial climate state of a pharmacy institution has been determined. The system for monitoring the state of the psychosocial climate in the workforce of a pharmacy has been proposed, namely: the monitoring object; the subject of monitoring; monitoring functions; monitoring indicators; control of the work of the pharmacy staff. The functions of monitoring the state of the psychosocial climate in a pharmacy workforce include analytical, diagnostic, predictive and organizationaland managerial functions.Conclusions. The relevance and necessity of managing the psychosocial climate in a pharmacy workforce has been determined. The stages of monitoring the psychosocial climate state in a pharmacy workforce have been proposed.Key words: psychosocial climate; pharmacy; workforce; monitoring; management.
The study of modern aspects of determining the costs of self-monitoring of diabetes mellitus
Authors: Vlasenko I. O. , Kubarieva I. V. , Davtian L. L., , Korzh Iu. V.
Published: August 2022

Aim. To study modern aspects of determining the costs of self-monitoring of diabetes mellitus.Materials and methods. When conducting the analysis the research objects were recommendations and regulations documents regarding the provision of medical care to diabetes patients (orders of the Ministry of Health of Ukraine, domestic and international clinical guidelines, recommendations of international organizations) and information on retail prices of glucometers and test strips in pharmacies of Kyiv, Lviv, Dnipro and Kharkiv (80 pharmacies) as of 10.01.2022. In the course of the research the content analysis, methods of grouping and summarizing data, mathematical and marketing analysis methods were applied.Results. Based on the generalization of these international recommendations and legal acts on the provision of medical care to patients with diabetes mellitus, 4 scenarios were identified regarding the number of measurements for self-monitoring. It was determined that foreign manufacturers formed the main range of glucometers for diabetes self-monitoring at the retail pharmaceutical market. The need for self-monitoring of diabetes mellitus per year was determined based on qualitative and quantitative indicators, depending on the type of diabetes mellitus and approaches to pharmacotherapy, taking into accountdomestic and international recommendations. It was found that the highest costs for test strips per year were observed for self-monitoring of Type І diabetes (5,986.0-15,622.0 UAH), and insignificant for Type ІІ diabetes with diet therapy (213.2 to 556.4 UAH). In addition, the following costs of self-monitoring (glucometer + test strips) for 1 year were found: for Type І diabetes (insulin therapy) – UAH 6,318.0-15,997.0, for Type ІІ diabetes (insulin therapy) – UAH 4,821.5-12,091.5, Type ІІ diabetes (oral hypoglycemic therapy) – UAH 2,464.0-5,939.0, Type ІІ diabetes (diet therapy) – from UAH 545.2 to UAH 1,165.6.Conclusions. Based on the analysis conducted, it has been determined that in Ukraine it is appropriate to develop measures to introduce reimbursement of costs for self-monitoring devices, namely glucometers and test strips for all categories of patients. This will help to encourage patients to conduct self-monitoring and, as a result, will become a significant factor in preventing the development of diabetes complications.Key words: retail price; diabetes; costs; self-monitoring.
Empleabilidad profesional: Inserción y movilidad en mercados de trabajo de egresados(as) de la Universidad del Valle
Authors: Rentería Pérez Erico , García Sánchez Efraín , Malvezzi Sigmar , Botero Sarassa Jimena
Published: August 2022

Un gran debate contemporáneo relacionado con los encargos sociales de la educación superior abarca cuestiones como la pertinencia, legitimidad y capacidad de las universidades para identificar las necesidades de los mercados de trabajo y promover la formación de personas capaces de responder a las mismas. Estas exigencias generan tensiones al interior de las Instituciones de Educación Superior (IES), dado que algunos autores y actores institucionales las asocian con la mercantilización de la educación, que implica poner las instituciones al servicio del mercado, lo cual limita la formación de agentes sociales críticos, y genera pérdida de autonomía y libertad universitaria. No obstante, la universidad como espacio privilegiado de formación, cumple un papel clave en la inclusión y movilidad social por el trabajo de sus egresados(as). En el marco de estas aproximaciones surge este libro, el cual recopila resultados de investigación sobre recursos y condiciones de empleabilidad de profesionales egresados(as) de nivel de pregrado de la Universidad del Valle entre los años 2013 y 2017, además de discusiones derivadas de otras investigaciones y publicaciones de maestría y doctorado en la línea de investigación sobre “Aspectos psicosociales del trabajo como actividad económico-productiva” del Grupo de Investigación en Psicología Organizacional y del Trabajo (Grupo POT). Se presentan datos, referenciales conceptuales y discusiones relacionadas con las formas como los profesionales son incluidos socialmente a través del trabajo en los diferentes campos de formación específicos de la economía formal principalmente, sin dejar de explorar otras formas y economías (Rentería, 2019). Se presenta un modelo conceptual multimensional que incluye aspectos individuales como las estrategias, competencias y características; así como condiciones estructurales de tipo socioeconómico, cultural, dispositivos de formación, y de relaciones de trabajo (Botero y Rentería, 2019). Los resultados muestran la complejidad del fenómeno, y dan al lector individual o institucional recursos para su estudio y la proyección de acciones relacionadas.
Modified Ziehl–Neelsen staining for Mycobacterium leprae
Authors: Mohan Neelima , Sunil Minu , Akhil Gopinadhan , Priya Sujaya Krishna , Vijayakumar Vrinda , Vineetha Mary , Celine Machiyanickal Isaac , Ajithkumar Kidangazhiathmana
Published: August 2022

Modified Ziehl–Neelsen staining for Mycobacterium leprae is a time-tested technique in the evaluation of leprosy. The staining helps to classify clinical types of leprosy into those with low and high bacillary load. It is also useful in assessing the response to therapy, identifying defaulters, and differentiating relapse from late reversal reactions. In this net educational video, we demonstrate the technique of taking an ear lobe smear and performing the modified Ziehl–Neelsen staining for acid fast bacilli.
Aggressive dissemination of central nervous system hemangioblastoma without association with von Hippel–Lindau disease: A case report and literature review
Authors: Dantas François , Raso Jair Leopoldo , Braga Patrícia Salomé Gouvea , Botelho Ricardo Vieira , Dantas Fernando Luiz Rolemberg
Published: August 2022

Background:

Hemangioblastomas (HBs) typically present with benign behavior and are most commonly found in the posterior fossa. Multiple central nervous system (CNS) HBs are usually associated with von Hippel–Lindau disease, and leptomeningeal dissemination of sporadic HBs is extremely rare. A review of the literature identified 30 cases of leptomeningeal dissemination of sporadic HBs previously published in the literature.

Case Description:

We report the case of a patient who was diagnosed with multiple CNS HBs with aggressive progression 6 years after resection of a posterior fossa HB. He underwent multiple surgeries and died 4 years after the diagnosis of the first spinal dissemination.

Conclusion:

Dissemination of sporadic HBs is rare and aggressive disease evolution is usually observed. Further studies are necessary to determine the optimal therapeutic options.
Navigated 3D ultrasound-guided resection of high-grade gliomas: A case series and review
Authors: Habib Ahmed , Jovanovich Nicolina , Hoppe Meagan , Hameed N.U. Farrukh , Edwards Lincoln , Zinn Pascal
Published: August 2022

Background:

The crux in high-grade glioma surgery remains maximizing resection without affecting eloquent brain areas. Toward this, a myriad of adjunct tools and techniques has been employed to enhance surgical safety and efficacy. Despite intraoperative MRI and advanced neuronavigational techniques, as well as augmented reality, to date, the only true real-time visualization tool remains the ultrasound (US). Neuroultrasonography is a cost-efficient imaging modality that offers instant, real-time information about the changing anatomical landscape intraoperatively. Recent advances in technology now allow for the integration of intraoperative US with neuronavigation.

Case Description:

In this report, we present the resection technique for three cases of high-grade gliomas (two glioblastomas and one anaplastic astrocytoma). The patient presented with a variable clinical spectrum. All three cases have been performed using the Brainlab® neuronavigation system (BrainLAB, Munich, Germany) and the bk5000 US Machine® (BK Medical, Analogic Corporation, Peabody, Massachusetts, USA).

Conclusion:

Gross total resection was achieved in all three cases. The use of 3D navigated US was a reliable adjunct surgical tool in achieving favorable resection outcomes in these patients.
Organizational Culture as a Development Resource in the Conditions of Changing Institutional Functions of Libraries
Authors: Negrul Svetlana V. , Putneva Yana K.
Published: August 2022

In the context of technological and socio-cultural transformations, libraries are in search for landmarks and new formats of activity. The vector of transformation of library functions is from the preservation and transmission of information to agentive: structuring communities, managing information, communicative functions. Libraries are becoming conductors of social innovation. The article considers organizational culture as a catalyst for the development of libraries in the future. The authors pose the problem of inconsistency of organizational culture with new demands and needs, as well as justify the need for the formation of an innovative type of culture. The paper presents the results of quantitative and qualitative research in the Municipal Information Library System (MILS) of Tomsk in 2021. Questionnaires and interviews were conducted with employees of three libraries of Tomsk MILS, one of which took part in the Federal project “Cultural Environment” of the National project “Culture” on the creation of model municipal libraries. The authors study organizational culture at the formal and informal levels. The analysis showed that each of the libraries demonstrated insufficient level of compliance with the context of social transformations. Barriers of organizational culture in public libraries are conservative mission, management attitudes to support performing competencies, features of clan culture (orientation to isolation, lack of openness for cooperation on the part of staff both within the library network and with external communities, underestimation of the role of partnership), technological focus of activities, etc. Reserves for the development of organizational culture are the willingness of staff to take initiatives, focus on support and building positive relationships in the team. As an opportunity to manage organizational culture, the authors note that transformations should begin with a change of emphasis in the libraryʼs mission based on a new spatial approach.
Scientist-Encyclopedist T.I. Rainov — the Invited Chief Bibliographer of the V.I. Lenin State Library
Authors: Ilizarov Simon S.
Published: August 2022

On the basis of archival materials introduced into scientific circulation for the first time, the author considers the activity of the scientist-encyclopedist Timofey Ivanovich Rainov (1890, Kalchevo village, Akkerman district, Bessarabian province of the Russian Empire — 1958, Moscow), worked as visiting specialist-bibliographer of highest qualification in the V.I. Lenin State Library of the USSR in 1938—1941 and in 1948—1950. The paper shows that before Rainov was invited to the V.I. Lenin State Library, he passed a long way, gaining skills and competencies in the field of library science and bibliography. Unable to work freely in Soviet Russia as a philosopher and specialist in the psychology of creativity, T.I. Rainov, like other Russian intellectuals, was seeking ways to realize his research potential. In 1923, the scientist moved to Moscow, where the Library of the Socialist (Communist) Academy (later the Fundamental Library of Social Sciences of the USSR Academy of Sciences, FBON) became his main place of work. Possessing encyclopedic knowledge and immense erudition, he took the place of leading bibliographer. T.I. Rainov changed several professions, but, remaining invariably a researcher of scientific ideas, he repeatedly returned to the field of book studies and bibliography and completed his service in this field at the FBON. The article examines the main life circumstances that led him to the V.I. Lenin State Library, and it was found that when concluding an employment contract with him, T.I. Rainov was obliged to provide consultations “on all branches of knowledge” to both employees and readers of the V.I. Lenin State Library of the USSR.

The appendix presents the experience of compiling an article about the scientific bibliographer T.I. Rainov for the forthcoming reference book “Employees of the Russian State Library: Eminent Scientists and Workers in Culture”.
Implementation of the principles of modular learning in an educational organization
Authors: Прядехо А. А. , Карбанович О. В. , Степченко Т. А.
Published: August 2022

Динамичное развитие информационного пространства, его насыщенность и разноплановость способствуют совершенствованию фундаментальных подходов к качественной подготовке специалистов – инициативных, творческих граждан, наделенных чувством долга, ответственности, активный и таких, которые умеют быстро адаптироваться к новым условиям, стремительно обучаться и постоянно развиваться. Этого можно достичь при условии формирования у студентов чувства самостоятельности и творчества (критического мышления), а это осуществляется путем внедрения в образовательный процесс ключевых принципов модульного обучения. Современное образование наряду со становлением национальной и общественно-политической независимости уверенно шагает к модернизации учебных технологий. Важной задачей быстрой адаптации образования к международному, социокультурному и профессиональному пространству является реформирование Российской школы, ведь выпускники заполняют важную нишу рынка труда через приобретенную профессиональную компетентность.

The dynamic development of the information space, its richness and diversity contribute to the improvement of fundamental approaches to high–quality training of specialists - initiative, creative citizens endowed with a sense of duty, responsibility, active and those who are able to quickly adapt to new conditions, learn rapidly and constantly develop. This can be achieved if students develop a sense of independence and creativity (critical thinking), and this is done by introducing the key principles of modular learning into the educational process. Modern education, along with the formation of national and socio-political independence, is confidently moving towards the modernization of educational technologies. An important task of rapid adaptation of education to the international, socio-cultural and professional space is the reform of the Russian school, because graduates fill an important niche of the labor market through acquired professional competence.