bluuebunny/crossref_metadata_2025 huggingface dataset:
Well-Being and Evolving Work Autonomy: The Locus of Control Construct Revisited
Authors: Terry Paul E.
Published: March 2022

Will the new ways we work have positive or negative effects on well-being? How will hybrid work arrangements, flexible schedules, and increased telework impact job satisfaction and life satisfaction? Many factors related to employee productivity, creativity, and collaboration are being assessed as organizations consider how less time spent at a workplace impacts work culture and organizational success. This editorial argues that the internal–external locus of control construct could offer useful insights into the differential affects that new work arrangements may have on worker satisfaction. For many, greater autonomy will be felt as consistent with their beliefs and preferences for greater control in how they perform their work. Others may feel more stressed by the loss of structure and direction provided in a traditional workplace setting. Principles of motivation are discussed alongside the potentialities and hazards attendant to changes in the longstanding social contract between employers and employees.
Effects of poling direction and imperfection of interfaces on a pre-stressed system with a piezoelectric core bonded to elastic faces
Authors: Daşdemir Ahmet
Published: March 2022

This paper models the resonance behavior of an initially stressed sandwich plate-strip consisting of a piezoelectric core and elastic faces, based on a rigid foundation, exposed to a time-harmonic force. Our research is conducted according to the linearized theory of electro-elasticity for solids under initial stress. This model assumes that there is a spring-type imperfectness at interfaces between the piezoelectric core and the face materials, both in the normal and tangential directions, and the core layer is poling in various directions. A mathematical model is created for the current problem, and then the finite element method (FEM) is used to solve it. Further, attention is focused on the influence of the mentioned imperfectness and the poling directions on the frequency response of plate-strip, in addition to the effects of the most important parameters on this response. The results show that as the imperfectness at the interface planes has the greatest effect on the horizontal polarization of the piezoelectric core, the mentioned polling direction inhibits the resonance mode of the system.
Orbital perturbation analysis and generation of nominal near rectilinear halo orbits using low-thrust propulsion
Authors: Du Chongrui , Starinova Olga L
Published: March 2022

The near rectilinear halo orbit (NRHO) is a potential orbit for the establishment of lunar space station. This research is focused on the analysis of major orbital perturbations on NRHOs and the generation of nominal orbit using a low-thrust engine in the ephemeris model. First, the NRHO family is defined in the circular restricted three-body problem (CRTBP). Then, different perturbations are performed to integrate the spacecraft motion along the NRHOs; meanwhile, a modified momentum integral is employed to calculate the orbit deviation in the case of each perturbation examined independently. By this way, these perturbations are classified according to the magnitude of impact on NRHOs. Finally, combined with a fuel-optimal control, a target-point strategy generating the nominal-controlled NRHO in the real Earth–Moon system is proposed using low-thrust technology. By selecting a fixed point from the original NRHO, the spacecraft is forced to depart from this point and then return to it, thereby forming a controlled closed trajectory. This provides an alternative nominal orbit for the future application of the low-thrust engine to lunar exploration missions.
LINC00092 Suppresses the Malignant Progression of Breast Invasive Ductal Carcinoma Through Modulating SFRP1 Expression by Sponging miR-1827
Authors: Zhao Chun-Ming , Li Lin-Lin , Xu Jia-Wen , Li Zhi-Wei , Shi Peng , Jiang Rui
Published: March 2022

Breast invasive ductal carcinoma (IDC) is a most common kind of breast cancer (BC), yet to date the corresponding effective therapies are limited. Extensive evidence has indicated that lncRNAs are involved in multiple cancers, and the potential mechanism of lncRNAs, such as LINC00092, mentioned in IDC remains elusive. IDC clinical samples from TCGA database were used to analyze the expression levels of LINC00092, miR-1827 and SFRP1. Kaplan-Meier method was applied to plot the overall survival curves. KEGG and GO were employed to screen the pathway that LINC00092 participated in. Pearson’s correlation analysis determined the relationship between LINC00092 and SFRP1. Bioinformatics analysis and dual-luciferase reporter assay examined the association among LINC00092, miR-1827, and SFRP1. Cell counting kit-8, colony formation and transwell assays were performed to detect cell viability, colony formation, and migration and invasion, respectively. Quantitative reverse-transcription polymerase chain reaction and western blot were utilized to investigate the expression at RNA and protein levels. LINC00092 expression was down-regulated in IDC tissues and cells, which was correlated with poor prognosis. Down-regulated LINC00092 facilitated cell proliferation, colony formation, and cell migration and invasion, while up-regulated LINC00092 inhibited cell malignant behaviors. LINC00092/SFRP1 physically bound to miR-1827 in IDC. SFRP1 expression was proportional to LINC00092 expression and inversely proportional to miR-1827 expression. The inhibitory effects of LINC00092 on cell aggressive behaviors were partially regulated by miR-1827/SFRP1. In summary, our results indicated that overexpression of LINC00092 inhibited the development of IDC through modulating miR-1827/SFRP1 axis, suggesting new therapeutic targets to treat IDC.
Reflections on the Use of Evidence in Child Welfare: A Commentary on Barth et al.
Authors: Font Sarah A.
Published: March 2022

To create a child welfare system that meets the needs of abused and neglected children, it is essential to critically evaluate core claims and assumptions about how the current child welfare system operates and its impacts on children and families. Yet, misleading and false claims are frequently repeated in academic, professional, and media outlets. Barth and colleagues (2021) sought to name and evaluate some of these claims, reasserting the central role of research evidence in policy and practice debates. In this commentary, I argue that a commitment to “consider the evidence” may do little to improve the quality of policies or practices in the child welfare system. Rather, I assert that because research findings are commonly mischaracterized and overgeneralized, we are left with widespread disagreement about what to conclude from existing research and how certain those conclusions are.
Efficacy of Drug-Eluting Beads Transarterial Chemoembolization Plus Camrelizumab Compared With Conventional Transarterial Chemoembolization Plus Camrelizumab for Unresectable Hepatocellular Carcinoma
Authors: Ren Yanqiao , Guo Yusheng , Chen Lei , Sun Tao , Zhang Weihua , Sun Bo , Zhu Licheng , Xiong Fu , Zheng Chuansheng
Published: March 2022

Objectives

The purpose of this study was to compare the efficacy and safety of drug-eluting beads transarterial chemoembolization plus camrelizumab (D-TACE-C) with conventional transarterial chemoembolization plus camrelizumab (C-TACE-C) in the treatment of patients with unresectable hepatocellular carcinoma (HCC).

Materials and Methods

This was a retrospective study that evaluated the consecutive medical records of patients with unresectable HCC who had undergone D-TACE-C or C-TACE-C from April 2020 to August 2021. Efficacy of treatment was evaluated using tumor response, progression-free survival (PFS) and survival rates. The adverse events were recorded.

Results

A total of 54 patients were included in this study, including 27 patients who had received D-TACE-C treatment, and 27 patients who had received C-TACE-C treatment. The median PFS and DCR in the D-TACE-C group were significantly longer than those for the C-TACE-C group (PFS: 10 vs. 3 months, P=.017; DCR: 70.4% vs. 40.7%, P = .028). Cox regression analysis showed that D-TACE-C was the only protective factor for PFS. The 6-month and 12-month survival rates in D-TACE-C group and C-TACE-C group were 85.2% versus 79.4% (P = .646) and 65.2% versus 65.1% (P = .903), respectively. Reactive cutaneous capillary endothelial proliferation was the most common adverse event associated with the treatment. There was no significant difference in the adverse events related to TACE and camrelizumab between the two groups. No treatment-related deaths occurred in this study.

Conclusions

D-TACE-C is a safe and well-tolerated treatment, and may produce better PFS and tumor response in patients with unresectable HCC than C-TACE-C.
Clinical Characteristics and Prognosis of Small Cell Carcinoma in the Nasopharynx: A Population-Based Study
Authors: Zhou Yu-ling , Peng Ying-peng , Liu Qiao-dan , Chen Xian-zhen , He Jianzhong , Wei Wei , Zhong Gui-hua , Zhang Ya-qin , Liu Ye , Pan Jia-ying , Feng Shao-yan , Liu Zhi-gang
Published: March 2022

Background

Nasopharyngeal small cell carcinoma (SmCC) is a rare histological type of nasopharyngeal cancer, and its prognosis remains poor. This study aimed to determine the clinical characteristics and survival prognostic factors of nasopharyngeal SmCC.

Methods

Detailed clinicopathologic and therapeutic characteristics of a patient diagnosed with nasopharyngeal SmCC were determined. Nasopharyngeal SmCC cases reported previously were reviewed and summarized. Furthermore, a retrospective analysis was performed on data from the Surveillance, Epidemiology, and End Results (SEER) Program database. Kaplan–Meier analysis was conducted to compare survival within groups. Univariate and multivariate analyses were performed to investigate prognostic factors.

Results

A nasopharyngeal SmCC patient treated with chemoradiotherapy who achieved 46 months long-term survival was reported. In reviewing 16 reported cases with epidemiologic and therapeutic details, we found most of nasopharyngeal SmCC patients were diagnosed with advanced grades and received chemoradiotherapy. In total, 13,993 cases of nasopharyngeal cancer were extracted from the SEER database, from which 57 nasopharyngeal SmCC cases were eventually screened out. The mean age of the patients was 55.70 years, and 64.9% of these cases were either grade III or IV; the median overall survival (OS) was 18 months. Statistically significant differences were observed in the OS values of groups categorized by age (P = .025) or radiotherapy (P = .037). Age (<70 years) and radiotherapy were identified as independent survival and prognostic factors.

Conclusion

Patients with nasopharyngeal SmCC are usually diagnosed with advanced grades and have poor prognoses; nevertheless, they can benefit from radiotherapy with prolonged overall survival.
Research on the resonance frequency splitting mechanism and novel modal characteristics of a rotating tire acoustic cavity
Authors: Liu Xiandong , Zhao Wei , Hu Xiaojun , Shan Yingchun , He Tian
Published: March 2022

Tire acoustic cavity resonance (TACR) noise contributes significantly to interior noise for lower powertrain noise passenger cars and electric cars, which affects the ride comfort obviously. To design sound absorption structures effectively, it is crucial to clarify the evolution mechanism and influence factors of the resonance frequencies and acoustic modal shapes with the running speed. Aiming at these problems, in this paper, a theoretical model of sound wave propagation in a tire acoustic cavity is constructed based on the superposition principle of traveling waves, and the sound field distributions under different rotating speeds are investigated. The formation conditions of TACR are summarized from the perspective of wavenumber. Especially for a rotating tire acoustic cavity, some novel modal characteristics, such as the novel deflective modal shapes and the continuously changing phase, are found. And the theoretical calculation results are verified by the experiment and simulation. The significance of this work is that the evolution mechanisms of TACR frequency and modal shape with the tire rotating speed are theoretically clarified and revealed, which are helpful to obtain effective solutions to suppress TACR noise.
Free vibration analyses of functionally graded plates based on improved refined shear and normal deformation theory considering thickness stretching effect using Airy stress function
Authors: Monajati Leila , Farid Navid , Farid Mehrdad , Parandvar Hassan
Published: March 2022

In this paper, an improved refined shear and normal deformation theory is used in order to investigate the vibration behavior of functionally graded rectangular plates. In this theory, displacements of various points of plate are assumed to be due to in-plane displacements of the middle plane and transverse displacement. Transverse displacement is divided into three parts: bending, shear, and thickness stretching. Using the Airy stress function, corresponding to the compatibility equation, and employing the extended Hamilton’s principle, in-plane displacements are omitted from the equations of motions. Thus, the proposed approach uses only three-unknowns in the displacement field. The results of vibration analysis using the proposed approach are in excellent agreement with three-dimensional and quasi-three-dimensional solutions containing a greater number of unknowns to consider the thickness stretching effect. Static and dynamic behavior of wide variety of thin and thick functionally graded plates can be studied using the proposed approach in which not only the number of variables is reduced, but also the contribution of bending, shear, and thickness stretching are completely clarified.
Threshold for Anaphylactoid Reaction to Polysorbate 80 in Canines
Authors: Holbrook Kristen , Andrews Dina , Sutherland Wes , Coppi Aldo , Barry Shane , Escamilla Max , Authier Simon , Miraucourt Loїs , Xie Fang , Rock Brooke , Bussiere Jeanine
Published: March 2022

Polysorbate 80 (PS80) functions as a dispersing agent or solubilizer in many pharmaceuticals, and as a stabilizer in biopharmaceuticals. Topical or parenteral administration of low doses of PS80 in biopharmaceuticals has been associated with mild allergic reactions, including local injection site reactions in humans. High doses of PS80, such as levels found in traditional Chinese herbal parenteral medicines, have been linked to systemic effects consistent with anaphylactoid-type reactions, which are characterized by the direct release of histamine from mast cells (degranulation). Nonclinical safety assessments of PS80 in vivo have mainly focused on canine model systems, a species established to be particularly sensitive to PS80. However, there is conflicting data about the dose and route of administration of PS80 required to elicit an anaphylactoid-type reaction in this model system. Therefore, studies using multiple dosing regimens in anesthetized and conscious dogs including a combination of cardiovascular data, clinical signs, and biomarkers of mast cell degranulation were conducted. An intravenous (IV) bolus of 1 mg/kg PS80 (0.25% w/v) elicited a positive anaphylactoid reaction including increased heart rate, hypotension, and clinical signs associated with anaphylactoid reactions (e.g., reddened muzzle). However, a full reaction was not observed with a subcutaneous (SC) injection of PS80 (0.25% w/v) up to 20 mg/kg and IV bolus or IV infusions up to 0.5 mg/kg. These data establish a threshold dose for eliciting an anaphylactoid reaction in canine which varies depending on the route of administration as well as the rate of PS80 infusion.
Toward Multisensory Customer Experiences: A Cross-Disciplinary Bibliometric Review and Future Research Directions
Authors: Stead Susan , Wetzels Ruud , Wetzels Martin , Odekerken-Schröder Gaby , Mahr Dominik
Published: March 2022

An in-depth understanding of multisensory customer experiences could inform and transform service experiences across the touchpoints of customer journeys. Sensory research in service and marketing disciplines mostly refers to individual senses in isolation. However, relevant insights could be gleaned from other disciplines to explore the multisensory nature of customer experiences. Noting the fragmented state of research surrounding such topics, the current article presents a systematic, objective overview of the content and theoretical foundations underlying the notion of multisensory customer experiences. Seeking a holistic understanding and research agenda for service research, the authors adopt both text mining and co-citation analyses overlaying findings from the cross-disciplinary foundation to uncover relevant theoretical, conceptual, and methodological developments. The resulting research agenda encourages scholars to employ diverse theories and methods to investigate multisensory stimuli, their integration, and perception, as well as the link between multisensory customer experiences and emotions. These insights then can inform the design of multisensory omnichannel service experiences.
Identification of Suitable Site-specific Recharge Areas using Fuzzy Analytic Hierarchy Process (FAHP) Technique: A Case Study of Iranshahr Basin (Iran)
Authors: Zaresefat Mojtaba , Ahrari Mohiuddin , Reza Shoaei Gholam , Etemadifar Mahin , Aghamolaie Iman , Derakhshani Reza
Published: March 2022

Iranshahr Basin is located in the Sistan and Baluchistan province, subject to severe drought and excessive groundwater utilization. Over-reliance on groundwater resources in this area has led to aquifer drawdowns and socio-economic problems. The present study aimed to identify appropriate sites for Artificial Recharge Groundwater (ARG) in a single platform by applying GIS fuzzy logic spatial modeling. Three stages were performed. In stage one, nine factors affecting ARG were collected based on the literature review. In stage two, geology, soil, and land-use layers were digitized from the existing maps. Some layers such as rainfall, unsaturated thickness, water quality, and transmissivity data were imported to ArcGIS environments, and their surface maps were made by Ordinary Kriging (OK) method. In stage three, the parameters were standardized with the fuzzy membership functions, and the GAMMA 0.5 fuzzy overlay model was applied for aggregation parameters. Results showed that 72.8%, 16.7%, 7.7%, 2.5% of the areas were classified as unsuitable, moderate, suitable, and perfectly suitable sites for planning a groundwater recharge site. Subsequently, the minimum area required regarding the possible errors based on the literature review determined six sites (A–E) as areas with higher priority. Then, the recommended unsuitable/suitable sites were validated and omitted by using some more detailed views. Finally, two sites (E and F) were omitted, and four sites (A, B, C, D) were recommended for future artificial recharge planning.
The effect of the Development and Well-Being Assessment as an adjunct to standard referral letters on referral decisions by child and adolescent mental health services — a randomized feasibility trial
Authors: Hansen Anna Sofie , Kjaersdam Telléus Gry , Mohr-Jensen Christina , Færk Emil , Lauritsen Marlene Briciet
Published: March 2022

Background: High rejection rates for referrals to child and adolescent mental health services (CAMHS) are common. The most cited reasons for rejection are that the child does not have a clinical need for assessment and poor quality of the referrals. However, studies of interventions aimed at improving appropriateness of referrals are sparse. Methods: In this randomized feasibility trial, we tested if the Development and Well-Being Assessment (DAWBA) as an adjunct to referral letters could improve accuracy of referral decisions made by CAMHS. The primary outcome of the study was the proportion of “correct” referral decisions. Results: The study included 160 children referred to CAMHS. Almost all (95.6%) participants fulfilled criteria for a mental disorder and 82.1% also reported high impact of symptoms. Compared to the group who did not complete the DAWBA, referral decisions for the DAWBA group showed higher sensitivity (0.63 vs. 0.83), specificity (0.30 vs. 0.42), and negative predictive value (0.14 vs. 0.36) as well as slightly higher positive predictive value (0.81 vs. 0.86). Conclusions: The use of the DAWBA as an adjunct to standard referral letters could lead to more correct referral decisions and reduce the proportion of wrongful rejection referrals to CAMHS.
Flexural capacity of steel-UHTCC (ultra-high toughness cementitious composite) bridge deck considering different shear connection degrees
Authors: Li Qing-Hua , Wang Guo-Zhong , Tong Jing-Zhong , Xu Shi-Lang
Published: March 2022

Due to the excellent cracking prevention behavior of ultra-high toughness cementitious composite (UHTCC), the stud number and reinforcement ratio of composite bridge decks could be reduced, and hence the fatigue properties could be improved. In this study, a theoretical model was proposed to predict ultimate flexural capacity of steel-UHTCC composite bridge decks with different shear connection degrees. To evaluate the accuracy of the theoretical model, 10 examples were designed for finite element (FE) validation and parametric study, and the results indicated that the theoretical model can predict the ultimate flexural capacity of steel-UHTCC composite bridge decks with satisfactory accuracy. Then, quantitative analysis was conducted to reveal the effect of key design parameters on the ultimate flexural capacity. The design parameters involved in the parametric study included: (1) normalized stud number; (2) shear span length; (3) thickness of UHTCC slab; (4) reinforcement ratio; and (5) the number of longitudinal plate ribs. The reasonable range of the normalized stud number in a shear span can be determined between 0.5 and 1 in practical design and increasing of longitudinal reinforcement ratio has limited effect on ultimate flexural capacity of steel-UHTCC composite bridge decks.
A new dynamic zOnal model with air-diffuser (DOMA) - Application to thermal comfort prediction
Authors: Megri Ahmed , Yu Yao , Miao Rui , Hu Xiaoou
Published: March 2022

A new Dynamic zOnal Model with Air-diffuser (DOMA) was developed. Several case studies were investigated and tested to evaluate and validate this program using measurement data. This new model was integrated into a TRaNsient SYstems Simulation program library and coupled with the multi-zone thermal model. The DOMA/TRNSYS coupled model was then used to predict room temperature distribution over an entire day of a single-zone building. The results show that increasing the heating outputs of the electric floor system, for example, from 75 to 200 W/m2, would not effectively improve the indoor thermal comfort, since the thermostat will reach the set point first and then turn off the system before the room gets enough heat and reach a comfortable level. This indicates the importance of selecting an appropriate location and set point for the thermostat when using a floor heating system. This potential thermal comfort issue can only be identified through the two-node model with a dynamic zonal model rather than the conventional PMV model, which thus suggests that for optimizing indoor thermal comfort of a building equipped with a time-sensitive control strategy and/or HVAC system, the TSENS results obtained from the two-node model integrated with DOMA are more appropriate than PMVs.
Acceptance and Commitment Therapy (ACT) for Problematic Anger: A Case Study
Authors: Tifft Eric D. , Roberts Max Z. , Underwood Shannon B. , Forsyth John P.
Published: March 2022

Though anger is a common human emotion, the unfettered behavioral expression of anger is often costly, contributing to a range of functional impairments, poor quality of life, and both physical and mental health problems. The current case illustrates how a third-generation cognitive behavioral therapy, Acceptance and Commitment Therapy (ACT), may be effective in reducing suffering linked with problematic anger. The client (“Robert”), a treatment-naïve man of low socioeconomic status, presented to a university training clinic reporting problematic anger outbursts that interfered with his relationships at work and with his girlfriend. The therapist conceptualized Robert’s problematic anger through the ACT psychological flexibility model, wherein Robert’s anger appeared to function as experiential avoidance to distance him from underlying emotional hurt. The therapist used ACT over 27 sessions to reduce Robert’s psychological inflexibility while promoting more psychological flexibility. Early sessions highlighted the unworkability of Robert’s anger, whereas subsequent sessions focused on clarifying values, loosening cognitive fusion, facilitating present moment awareness, and cultivating mindful acceptance in the service of living a meaningful life. The therapist monitored treatment progress using quantitative measures and qualitative reports. Collectively, the client showed notable gains. The case study adds to the growing body of literature supporting ACT for problematic anger.
Health Care Professional Perceptions About a Proposed NICU Intervention: The Importance of Community and Aligning With Everyday Occupations
Authors: Richter Marinthea , Smith Joan , Pineda Roberta
Published: March 2022

The neonatal intensive care unit (NICU) is a dynamic system with multiple stakeholders and contextual factors impacting the implementation of novel practices. This qualitative study aimed to (a) define health care professionals’ perceptions on the feasibility of implementing a sensory intervention to study its efficacy, and (b) elaborate on transactions occurring between NICU health care professionals and the proposed research. Eleven NICU professionals participated in one of three focus groups that were audio-recorded, transcribed, and analyzed thematically in NVivo first descriptively and then interpretively through a transactionalism lens. The health care professionals implied the intervention was feasible, but provided multiple suggestions to enhance implementation. The modification of familiar occupational practices, ingrained habits, and the potential impact on the collective occupational performance of NICU community members arose. Understanding occupations within the NICU as transactional allows for a broader view of occupational engagement and enhances knowledge of the nuances related to implementing clinical changes.
A PILOT STUDY on the Clinical and Functional Outcomes of an Improvised Technique of Core-cut Fistulectomy for Fistula-in-ano
Authors: Parwez Masoom , Huda Tanweerul , Yadav Moorat S. , Gupta Kamal , Mital Kushal , Pandya Bharati
Published: March 2022

Background

Anal fistulae are difficult to treat entities and minimally invasive procedures are evolving with promises. Our improvised technique is a simple and easy day-care procedure for simple fistulae.

Aim

To evaluate the outcomes of a technical modification in the procedure of core-cut fistulectomy in simple cryptoglandular fistula-in-ano.

Methods

47 patients of fistula-in-ano presenting to the out-patient of the General Surgery department at All India Institute of Medical Sciences, Bhopal, from November 2018 to March 2020 were selected. A complete history, physical examination followed by relevant investigations were meticulously performed and recorded. They were operated using an improvised core-cut technique, under a pudendal nerve block. Patients were kept on follow-up for a minimum of 6 months period to note the outcome of the surgery.

Results

The mean age was 37 ± 13.17 years with a male: female ratio of 5.1:1. The most common clinical presentation was perianal discharge in 96% of patients followed by pain and pruritus ani in 45% and 32%, respectively. 93.62% were inter-sphincteric, and 6.38% were trans-sphincteric. Extra-sphincteric and supra-levator fistulae were excluded from the study. The mean operative time was 17 ± 10.19 minutes. The mean healing time was 19.21 ± 5.99 days. The success rate of this novel technique of core-cut was calculated to be 89.37%. The rate of recurrence was calculated to be 10.63% (5 out of 47 patients). None of our patients developed incontinence.

Conclusion

Our pilot study results for simple fistulae-in-ano had less morbidity, postoperative pain, better wound healing, patient satisfaction, and compliance with low risk of recurrence, and no incontinence. It could hence be recommended for larger groups and more complicated fistulae in the future.
Safety and effectiveness of gemcitabine for the treatment of classic Kaposi’s sarcoma without visceral involvement
Authors: Badalamenti Giuseppe , Incorvaia Lorena , Algeri Laura , Bonasera Annalisa , Dimino Alessandra , Scalia Raimondo , Cucinella Alessandra , Madonia Giorgio , Pomi Federica Li , Galvano Antonio , Gristina Valerio , Toia Francesca , Cordova Adriana , Bazan Viviana , Russo Antonio
Published: March 2022

Background:

Classic Kaposi’s sarcoma (CKS) is a rare, multifocal, endothelial cell neoplasm that typically occurs in elderly people with previous infection by human herpes virus-8. Prospective trials are rare, and the choice of drugs relies on prospective trials performed on HIV-associated Kaposi’s sarcoma (KS). Pegylated liposomal anthracyclines and taxanes are considered the standard first- and second-line chemotherapy, respectively. Despite the indolent biologic behavior, the natural history is characterized by recurrent disease. This condition of chronic administration of cytotoxic drugs is often associated with immediate/long-term adverse events.

Methods:

This was an observational, retrospective study to evaluate the effectiveness and safety of gemcitabine in patients with CKS. From January 2016 to September 2021, the patients were treated with gemcitabine 1000 mg/m2 on days 1 and 8, with cycles repeated every 21 days. The treatment was administered as first or second line.

Results:

Twenty-seven (27) patients were included in the study. Twenty-one (21) out 27 patients (77.8%) achieved a partial response (PR), including 8 patients with major response (MR) (29.6%) and 13 patients with minor response (mR) (48.2%); 2 (7.4%) showed a complete response (CR), 3 (11.1%) a stable disease (SD), and 1 (3.7%) a progressive disease (PD). Tumor responses were generally rapid, with a median time to first response of 4 weeks (range, 3–12 weeks). Patients who responded had disease improvement with flattening of the skin lesions, decrease in the number of lesions, and substantial reduction in tumor-associated complications. Median duration of response was 19.2 months. Common adverse events were grades 1/2 thrombocytopenia, and grade 1 noninfectious fever. No patient discontinued treatment as a result of adverse events.

Conclusion:

Our study showed that gemcitabine is effective and well tolerated, acts rapidly on cutaneous lesions, and allows substantial symptom palliation, without dose-limiting toxicity. Gemcitabine represents a safe and effective option for the treatment of CKS.
Topical heparin as an effective and safe treatment for patients with capecitabine-induced hand-foot syndrome: results of a phase IIA trial supported by proteomic profiling of skin biopsies
Authors: Rodríguez-Garzotto Analia , Iglesias-Docampo Lara , Díaz-García C. Vanesa , Ruppen Isabel , Ximénez-Embún Pilar , Gómez Carlos , Rodríguez-Peralto J. Luis , de Frutos Javier Ortiz , Lopez-Martin Jose A. , Grávalos Cristina , Cortés-Funes Hernán , Agulló-Ortuño M. Teresa
Published: March 2022

Background:

Hand-foot syndrome (HFS) is a common adverse reaction associated with capecitabine chemotherapy that significantly affects the quality of life of patients. This study evaluates the safety and effectiveness of a topical heparin (TH) treatment on the clinical manifestations and anatomopathological alterations of capecitabine-induced HFS. In addition, we performed proteome profiling of skin biopsies obtained from patients with HFS at baseline and after heparin treatment.

Methods:

Patients with grade ⩽ 2 HFS associated with capecitabine were included in this study. The primary end point was the effectiveness of TH in reducing HFS of any grade. Clinical improvement was evaluated by clinicians, and an improvement was perceived by patients who performed a weekly visual analog scale questionnaire. Secondary end points included a comparative histological analysis and protein expression in skin biopsies at baseline and after 3 weeks of HT treatment. Proteomic profiling was carried out using quantitative isobaric labelling and subsequently validated by a T-array.

Results:

Twenty-one patients were included in the study. The median TH treatment time was 7.6 weeks (range = 3.6–41.6 weeks), and the median response time was 3.01 weeks (95% CI = 2.15–3.97). At the end of treatment, 19 of 21 patients (90.48%) responded to treatment with a decrease in one or more grades of HFS. None of the patients experienced adverse effects related to TH usage, nor did they suspend chemotherapy treatment. The main findings observed in skin biopsies after treatment were a decrease in hyperkeratosis and lymphocytic infiltrates. The proteomic analysis showed altered expression of 34 proteins that were mainly related to wound healing, cell growth, and the immune response.

Conclusion:

Based on our results, topical heparin is an effective and safe treatment for clinical manifestations of HFS, probably due to the restauration of skin homeostasis after heparin treatment, as supported by our proteomics-derived data.

Trial registration:

EudraCT 2009-018171-13
The national shaping of Europe’s emerging hydrogen strategies: Cooperative or competitive hydrogen Politics?
Authors: Machado Júlia T. M. , Flynn Brendan , Williamson Ian
Published: March 2022

In recent years, many European states have begun heavily investing in hydrogen (H2) technologies and as of July 2021, several have published detailed national hydrogen strategies. Nonetheless, it is evident there are emerging differences between these states regarding the scale, ambition and sophistication of their H2 plans. Such strategies also have implications for existing energy regimes that remain strongly dependent on fossil fuels alongside greater integration of renewables. Emerging H2 firms and technologies further disturb energy policies by either requiring a partly new, or at least modified, European energy infrastructure. Will such changes produce commercially dominant H2 businesses that could distort the broader energy market and confer a leading position upon a few countries and firms? There is also uncertainty over whether H2 technologies will support renewables by providing a ready means of energy storage, or whether investment in hydrogen could, paradoxically, displace some of the commercial interest in renewables. Finally, questions have been posed about the green credentials of H2 technologies. There are significant differences in how hydrogen is generated and much debate about the hydrogen colours. This paper employs a comparative analysis of three European national hydrogen strategies, offering a contrast between Germany, the UK and Portugal. The interaction between these and the EU level is mapped. Also explored is whether the various national styles favour more cooperative or competitive policy-making. The comparison with the UK allows us to explore some impacts Brexit may have on British H2 ambitions. To interpret these strategies, we employ the Multi-Level Perspective on energy transitions, which focuses on how different actors have a variable influence at mutually reinforcing levels of policymaking (niches, regime and landscape). These include EU institutions, national governments and agencies. Energy and technology firms and research networks are also crucial. We draw attention to several fundamental regulatory challenges that H2 strategies raise. Also highlighted are differences and similarities between countries and the wider possible trajectories for future hydrogen development.
Growing Up White Saviors
Authors: Finnegan Amy C.
Published: March 2022

In an enduring moment of pandemic, racial reckoning, and grave economic inequalities, the question of how white people with privilege most effectively and ethically engage momentous social problems remains. I inquire whether those who have participated in the white savior complex earlier in their lives later commit to more critical, reflexive, and collective forms of social justice organizing. Based on 21 interviews and a survey with people who had formerly participated in advocacy pertaining to the protection of children affected by the Lord’s Resistance Army (LRA) war between 2008 and 2010, this work explores what enables the white savior complex, whether white saviors can change, and if so, what facilitates transformation. Ultimately, I argue that the white savior complex is about being extraordinary. It is part of a pursuit to find purpose. It is about being right and good—and it is about reaching out to assist another while avoiding examination of both oneself and the conditions that enable the suffering in the first place. I found that people who have been engaged in the white savior complex can and do change. Yet, growing up and transforming from the white savior complex is not inevitable. It takes time, new social networks, and education that cultivates critical consciousness. I conclude by naming antidotes to the white savior complex: efforts which place lineage, humility, and curiosity at the center. Such efforts incorporate accountability and critical feedback and invoke concerted reflection on structural determination as well as personal social location identities and motivations.
Factors affecting turnover intentions among Millennial public relations professionals: The Latin American case
Authors: Moreno Angeles , Navarro Cristina , Fuentes-Lara Cristina
Published: March 2022

As the Millennial generation becomes the largest generation of the global workforce, it is vital that organizations understand Millennials’ work values, motivational factors, and expectations to adjust existing employee retention techniques that may not suit this generation. The purpose of this study is to identify and analyze the major factors that affect employee retention among Latin American Millennials working in the public relations industry. Additionally, we examine generational differences in work attitudes across three generations, with an emphasis on the nature of the similarities and differences of Millennials when compared to prior generations. Findings show a highly significant positive relationship among job satisfaction, trust in the organization, job engagement, excellent leader performance, and supportive organizational culture and Latin American Millennial turnover intentions. Compared to Boomers and Gen-Xers, Millennials reported lower levels of overall job satisfaction, work engagement, and organizational trust.
Timing of Surgery for Hip Fracture in Patients on Direct Oral Anti-coagulants: A Population-Based Cohort Study
Authors: Goh En Lin , Chidambaram Swathikan , Rai Suprabha , Kannan Angela , Anand Sambandam
Published: March 2022

Background

In patients with hip fracture on direct oral anti-coagulants (DOACs), timely surgery is important in optimising outcomes but the safety of early surgery is unclear. This study aims to evaluate the timing of surgery on peri- and post-operative outcomes in patients with hip fracture on DOAC therapy.

Methods

Single-centre, retrospective, population-based cohort study of patients on DOAC therapy compared to standard care with low-molecular-weight heparin (LMWH) undergoing surgery for hip fracture. Data obtained: patient demographics, fracture classification, American Society of Anaesthesiologists (ASA) classification, time to surgery, procedure performed, type of DOAC, timing of last DOAC dose, use of reversal agents or pro-coagulants and length of stay. Outcomes assessed: pre- and post-operative haemoglobin levels, incidence of blood transfusion, major haemorrhage, venous thromboembolism (VTE) and death within 30 days of surgery.

Results

A total of 755 patients were included. Compared to standard treatment, DOAC use was associated with a similar change in pre- and post-operative haemoglobin levels ( P = .90), risk of blood transfusion (RR: 1.04, 95% CI: .70–1.54, P = .84), haemorrhage (RR: 1.51, 95% CI: .53-4.28, P = .44), VTE (RR: .92, 95% CI: .12–7.20, P = .94) and mortality (RR: 1.85, 95% CI: .89–3.84, P = .10), all of which were independent of the timing of surgery.

Conclusion

This study builds on growing evidence that surgery for hip fracture in patients on DOAC therapy is not associated with an excessive risk of haemorrhage, irrespective of the timing of surgery. Timely surgical fixation of the hip fracture in this population is indicated in the absence of other risk factors for haemorrhage.
A norm inequality for three matrices
Authors: László Lajos
Published: March 2022

We prove a Frobenius norm inequality for three matrices, analogous to the well-known Bottcher--Wenzel inequality. The situation is also similar: standard inequalities would yield an upper bound, which however can be reduced by means of further, detailed investigations.
Percepciones sobre el plagio académico en un contexto de enseñanza digital universitaria
Authors: Gómez-Espinosa María , Clavel San Emeterio Mónica , Navaridas-Nalda Fermín
Published: March 2022

INTRODUCCIÓN. En un mundo en cambio permanente, caracterizado por el desarrollo exponencial de la tecnología, donde datos e información circulan sin barreras de tiempo ni espacio, la universidad necesita repensar su modelo de enseñanza y las consecuencias que se derivan de los modos de gestionar el aprendizaje del estudiantado que lo protagoniza. En este marco amplio de actuación, esta investigación tiene como objetivo principal identificar los factores que influyen en la realización de actividades de plagio entre el estudiantado universitario, teniendo en cuenta su percepción sobre los motivos que aluden para realizarlo y la gravedad que otorgan a esta práctica académica deshonesta. MÉTODO. Para ello, se ha adoptado un enfoque metodológico de carácter exploratorio, utilizando la técnica de encuesta como procedimiento más adecuado para la recogida de datos, sobre una muestra de 615 estudiantes en un contexto de enseñanza digital universitaria. RESULTADO. Los análisis realizados mediante Partial Least Squares Structural Equation Modeling (PLS-SEM) indican que el proceso de actuación docente percibido por los estudiantes (con relación a las tareas de aprendizaje, las creencias/actitudes frente a las conductas de plagio y el nivel de gravedad asignado por ellos a las prácticas deshonestas) tienen una relación estadísticamente significativa sobre la realización de actividades de plagio. DISCUSIÓN. Entre las conclusiones obtenidas, destaca la necesidad de elaborar un plan sistemático y continuo de formación del profesorado para combatir el plagio en cada universidad, apostando por el desarrollo de una cultura ética, de máximo respeto al aprendizaje, a partir de la reflexión compartida sobre los factores investigados.
Emotional management and self-efficacy associated with low stress levels in Spanish university teachers
Authors: García-Garnica Marina , Chacón-Cuberos Ramón , Expósito López Jorge , Martínez-Martínez Asunción
Published: March 2022

INTRODUCTION. Stress is defined as a state of physical and mental exhaustion, derived from a demanding context. Several national reports indicate that six out of ten teachers present medium to high levels of stress, affecting the quality of their professional activity. This perspective is extremely common in Higher Education. The aim of this research was to better understand the relationships between emotional management, stress and self-efficacy, alongside the effect of other academic and professional variables in Higher Education teachers. METHOD. The present study was descriptive, ex post-facto and cross-sectional and was performed with a sample of 798 Higher Education teachers from 15 Spanish universities, using IBM SPSS v.23.0 software for data analysis. RESULTS. Better emotional regulation was observed in males, those with a stable job and those working in the field of Science. Stress was higher amongst non-academic staff, whilst teaching staff perceived themselves to have greater self-efficacy when they reported family responsibilities and other obligations. Along these lines, teaching experience was determined to favour cognitive re-evaluation and self-efficacy, whilst also decreasing stress levels. This was especially the case amongst permanent teaching staff. Further, emotional regulation favoured a decrease in stress and the development of self-efficacy. DISCUSSION. In conclusion, the need is established to conduct actions for the development of emotional regulation techniques within university teaching staff. This will allow one self to manage stressful situations and inoculate anxiety and stress derived from professional activity. Ultimately, it will result in an improvement in teaching activity, favouring the achievement of the proposed teaching objectives and the academic performance of students.
A conceptual understanding of civics education in Spain and the United States: a systematic review
Authors: Kells Sara
Published: March 2022

INTRODUCTION. How does one learn to live with others? What does it mean to be a citizen in a liberal democracy? How do we ensure the future of fragile democratic institutions? Civics education, the formative activity of training young generations to take part in society by way of encouraging active and informed participation in their democratic society, is an area of study long tied to the quest of answering these questions. METHOD AND RESULTS. Through a systematic review, the current article describes the conceptual evolution of civics education in Spain and the United States in the years 2000-2020. Eighty-four articles were included in the revision and were analyzed and coded qualitatively. Momentous events in both countries are juxtaposed with the academic publications in an effort to track shifts, inflection points, and changes of foci within the fields of study. DISCUSSION. The current article outlines the historical events in each country, such as the anti-austerity movement in Spain and the events of September 11th, as potential milestones within the conceptual evolution of the literature on civics education. This article represents the first phase of a larger research project contextualizing relevant historical events within the body of research in the fields of education, political science, and sociology as it relates to the study of civics education.