bluuebunny/crossref_metadata_2025 huggingface dataset:
A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK
Authors: Chiarelli Laurent R. , Mori Giorgia , Orena Beatrice Silvia , Esposito Marta , Lane Thomas , de Jesus Lopes Ribeiro Ana Luisa , Degiacomi Giulia , Zemanová Júlia , Szádocka Sára , Huszár Stanislav , Palčeková Zuzana , Manfredi Marcello , Gosetti Fabio , Lelièvre Joël , Ballell Lluis , Kazakova Elena , Makarov Vadim , Marengo Emilio , Mikusova Katarina , Cole Stewart T. , Riccardi Giovanna , Ekins Sean , Pasca Maria Rosalia
Published: February 2018

Mycobacterium tuberculosis, the etiological agent of the infectious disease tuberculosis, kills approximately 1.5 million people annually, while the spread of multidrug-resistant strains is of great global concern. Thus, continuous efforts to identify new antitubercular drugs as well as novel targets are crucial. Recently, two prodrugs activated by the monooxygenase EthA, 7947882 and 7904688, which target the CTP synthetase PyrG, were identified and characterized. In this work, microbiological, biochemical, and in silico methodologies were used to demonstrate that both prodrugs possess a second target, the pantothenate kinase PanK. This enzyme is involved in coenzyme A biosynthesis, an essential pathway for M. tuberculosis growth. Moreover, compound 11426026, the active metabolite of 7947882, was demonstrated to directly inhibit PanK, as well. In an independent screen of a compound library against PyrG, two additional inhibitors were also found to be active against PanK. In conclusion, these direct PyrG and PanK inhibitors can be considered as leads for multitarget antitubercular drugs and these two enzymes could be employed as a “double-tool” in order to find additional hit compounds.
Anti-inflammatory effect of Tauroursodeoxycholic acid in RAW 264.7 macrophages, Bone marrow-derived macrophages, BV2 microglial cells, and spinal cord injury
Authors: Kim Seong Jun , Ko Wan-Kyu , Jo Min-Jae , Arai Yoshie , Choi Hyemin , Kumar Hemant , Han In-Bo , Sohn Seil
Published: February 2018

This study aimed to investigate the anti-inflammatory effects of tauroursodeoxycholic acid (TUDCA) after spinal cord injury (SCI) in rats. We induced an inflammatory process in RAW 264.7 macrophages, BV2 microglial cells, and bone marrow-derived macrophages (BMM) using lipopolysaccharide (LPS). The anti-inflammatory effects of TUDCA on LPS-stimulated RAW 264.7 macrophages, BV2 microglial cells, and BMMs were analyzed using nitric oxide (NO) assays, quantitative real-time polymerase chain reactions (qRT-PCR), and enzyme-linked immunosorbent assays (ELISA). The pathological changes in lesions of the spinal cord tissue were evaluated by hematoxylin & eosin (H&E) staining, luxol fast blue/cresyl violet-staining and immunofluorescent staining. TUDCA decreased the LPS-stimulated inflammatory mediator, NO. It also suppressed pro-inflammatory cytokines of tumor necrosis factor-α (TNF-α), interleukin 1-β (IL-1β), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) in both mRNA and protein levels. In addition, TUDCA decreased prostaglandin E2 (PGE2). After SCI, TUDCA supported the recovery of the injury site and suppressed the expression of inflammatory cytokines such as iNOS, CD68 and CD86. In addition, TUDCA induced the expression of anti-inflammatory cytokine, Arg-1. In conclusion, TUDCA inhibits inflammatory responses in RAW 264.7 macrophages, BV2 microglial cells, and BMMs. TUDCA can be a potential alternative drug for SCI.
Correction: Corrigendum: Variation-preserving normalization unveils blind spots in gene expression profiling
Authors: Roca Carlos P. , Gomes Susana I. L. , Amorim Mónica J. B. , Scott-Fordsmand Janeck J.
Published: February 2018

Scientific Reports 7: Article number: 42460; published online: 09 March 2017; updated: 12 February 2018. The Acknowledgements section in this Article is incomplete: “This work was supported by the European Union FP7 projects MODERN (Ref. 309314-2, to C.P.R., J.J.S.-F.), MARINA (Ref. 263215, to J.J.S.-F.
Carbon dots as analytical tools for sensing of thioredoxin reductase and screening of cancer cells
Authors: Sidhu Jagpreet Singh , Singh Ashutosh , Garg Neha , Kaur Navneet , Singh Narinder
Published: February 2018

The addition of Cu2+ to a CD solution quenches the fluorescence emission of CDs while on the addition of TrxR, 2-mercaptopropanoic acid released from the surface of the CDs and emission from CDs was regained.
Simultaneous determination of rifampicin, isoniazid, pyrazinamide and ethambutol in fixed-dose combination antituberculosis pharmaceutical formulations: a review
Authors: Oliveira M. A. L. , Chellini P. R. , Amorim T. L.
Published: February 2018

According to the World Health Organization, rifampicin, isoniazid, pyrazinamide and ethambutol hydrochloride are the first-line drugs used to treat tuberculosis – an infectious disease caused by Mycobacterium tuberculosis.
A novel IMAC platform – adenosine coupled functional magnetic microspheres for phosphoproteome research
Authors: Yan Yinghua , Lu Yujie , Chen Mengying , Liang Hongze
Published: February 2018

Immobilized metal affinity chromatography is a powerful method for phosphopeptide enrichment.
Co-administration of genistein with doxorubicin-loaded polypeptide nanoparticles weakens the metastasis of malignant prostate cancer by amplifying oxidative damage
Authors: Wang Guanyi , Zhang Dawei , Yang Shengcai , Wang Yalin , Tang Zhaohui , Fu Xueqi
Published: February 2018

Co-administration of genistein with doxorubicin-loaded polypeptide nanoparticles was used for prostate cancer treatment by amplifying oxidative damage.
Electrochemical initiation of electron-catalyzed phenanthridine synthesis by trifluoromethylation of isonitriles
Authors: Lübbesmeyer M. , Leifert D. , Schäfer H. , Studer A.
Published: February 2018

Electrochemical initiation of the trifluoromethylation of biaryl isonitriles verifies the electron's catalytic character in the examined cascade reaction.
Dynamical heterogeneities in ionic liquids as revealed from deuteron NMR
Authors: Khudozhitkov Alexander E. , Stange Peter , Bonsa Anne-Marie , Overbeck Viviane , Appelhagen Andreas , Stepanov Alexander G. , Kolokolov Daniil I. , Paschek Dietmar , Ludwig Ralf
Published: February 2018

Deuteron NMR spectroscopy is a suitable method to study dynamical heterogeneities in protic ionic liquids. In the2H spectra of the protic ionic liquid [TEA][OTf] we observe anisotropic and isotropic signals at the same time.
A giant M2L3 metallo-organic helicate based on phthalocyanines as a host for electroactive molecules
Authors: Fazio Ettore , Haynes Cally J. E. , de la Torre Gema , Nitschke Jonathan R. , Torres Tomás
Published: February 2018

An unprecedented phthalocyanine-based, metallo-organic helicate (Fe2Pc3) has been assembled and proved as a host for large redox-active guests such as fullerenes and naphthalenediimides.
Sensitive detection of intracellular microRNA based on a flowerlike vector with catalytic hairpin assembly
Authors: Liu Jintong , Du Ping , Zhang Jing , Shen Hong , Lei Jianping
Published: February 2018

A flowerlike nanovector with horn-shaped tips is developed for in situ detection of intracellular microRNA with multiple signal outputs.
Preparation, crystal structure and solution-mediated phase transformation of a novel solid-state form of CL-20
Authors: Pan Bochen , Dang Leping , Wang Zhanzhong , Jiang Jun , Wei Hongyuan
Published: February 2018

The crystal structure, thermodynamic phase diagram, and polymorphic transformation behaviors of CL-20 acetonitrile solvate are systematically investigated.
Self-assembled hierarchical architecture of tetragonal AgLa(MoO4)2 crystals: hydrothermal synthesis, morphology evolution and luminescence properties
Authors: Xia Wenpeng , Zhang Yufeng , Hu Shanshan , Xiong Jie , Tang Jianfeng , Yang Jun
Published: February 2018

Tetragonal AgLa(MoO4)2 microcrystals with novel discal hierarchical architectures were successfully synthesized via a one-step hydrothermal route.
Thermal, electrochemical and radiolytic stabilities of ionic liquids
Authors: Xue Zhimin , Qin Li , Jiang Jingyun , Mu Tiancheng , Gao Guohua
Published: February 2018

Ionic liquids show instability when exposed to high temperature, to high voltage as electrolytes, or under irradiation.
Multiscale design of ZnO nanostructured photocatalysts
Authors: Ramirez-Canon A. , Medina-Llamas M. , Vezzoli M. , Mattia D.
Published: February 2018

Light absorbance and crystal orientation, not surface area, determine the photocatalytic efficiency of immobilize ZnO nanowire films.
Understanding proton capture and cation-induced dimerization of [Ag29(BDT)12]3−clusters by ion mobility mass spectrometry
Authors: Chakraborty Papri , Baksi Ananya , Mudedla Sathish Kumar , Nag Abhijit , Paramasivam Ganesan , Subramanian Venkatesan , Pradeep Thalappil
Published: February 2018

We present a unique reaction of [Ag29(BDT)12]3−cluster with protons and dimerization of the cluster induced by alkali metal ions.
Atomic structure and electronic properties of A2B2XY (A = Si–Pb, B = Cl–I, and XY = PN and SiS) inorganic double helices: first principles calculations
Authors: Bijoy T. K. , Murugan P. , Kumar Vijay
Published: February 2018

The inner (PN or SiS) and outer (SnI and GeI) helices forming the Sn2I2PN and Ge2I2SiS inorganic double helices.
UV-induced long-lived decays in solvated pyrimidine nucleosides resolved at the MS-CASPT2/MM level
Authors: Pepino Ana Julieta , Segarra-Martí Javier , Nenov Artur , Rivalta Ivan , Improta Roberto , Garavelli Marco
Published: February 2018

The most relevant ‘dark’ electronic excited states in DNA/RNA pyrimidine nucleosides are mapped in water employing hybrid MS-CASPT2/MM optimisations with explicit solvation and including the sugar.
Control of triplet state generation in heavy atom-free BODIPY–anthracene dyads by media polarity and structural factors
Authors: Filatov Mikhail A. , Karuthedath Safakath , Polestshuk Pavel M. , Callaghan Susan , Flanagan Keith J. , Telitchko Maxime , Wiesner Thomas , Laquai Frédéric , Senge Mathias O.
Published: February 2018

Heavy atom-free BODIPY–anthracene dyads show triplet excited state formation via PeT, controlled by molecular rotation and environmental polarity.
Radiation-induced disorder in compressed lanthanide zirconates
Authors: Park Sulgiye , Tracy Cameron L. , Zhang Fuxiang , Park Changyong , Trautmann Christina , Tkachev Sergey N. , Lang Maik , Mao Wendy L. , Ewing Rodney C.
Published: February 2018

Swift heavy ion irradiation induces nanoscale defects by dense electronic excitation, which change the high-pressure phase stability fields of A2Zr2O7.
Key factors in pincer ligand design
Authors: Peris Eduardo , Crabtree Robert H.
Published: February 2018

This tutorial review analyses the reasons of success of pincer ligands.
Cinnamaldehyde hydrogenation using Au–Pd catalysts prepared by sol immobilisation
Authors: Cattaneo Stefano , Freakley Simon J. , Morgan David J. , Sankar Meenakshisundaram , Dimitratos Nikolaos , Hutchings Graham J.
Published: February 2018

We report the catalytic performance of Au–Pd nanoparticles prepared via a sol immobilisation technique for the catalytic hydrogenation of cinnamaldehyde under mild reaction conditions.
Cyclometalated N-heterocyclic carbene iridium(iii) complexes with naphthalimide chromophores: a novel class of phosphorescent heteroleptic compounds
Authors: Lanoë Pierre-Henri , Chan Jonny , Groué Antoine , Gontard Geoffrey , Jutand Anny , Rager Marie-Noelle , Armaroli Nicola , Monti Filippo , Barbieri Andrea , Amouri Hani
Published: February 2018

A novel class of phosphorescent heteroleptic iridium cyclometalated NHC complexes containing organic and inorganic chromophores has been reported.
Magneto-structural correlations in oxalate-bridged Sr(ii)Cr(iii) coordination polymers: structure, magnetization, X-band, and high-field ESR studies
Authors: Androš Dubraja L. , Jurić M. , Popović J. , Pajić D. , Krupskaya Y. , Kataev V. , Bűchner B. , Žilić D.
Published: February 2018

Magneto-structural correlations in 1D oxalate-bridged Sr(ii)Cr(iii) coordination polymers with two crystallographically and magnetically non-equivalent Cr(iii) ions are studied by HF-ESR spectroscopy.
An extremely safe and wearable solid-state zinc ion battery based on a hierarchical structured polymer electrolyte
Authors: Li Hongfei , Han Cuiping , Huang Yan , Huang Yang , Zhu Minshen , Pei Zengxia , Xue Qi , Wang Zifeng , Liu Zhuoxin , Tang Zijie , Wang Yukun , Kang Feiyu , Li Baohua , Zhi Chunyi
Published: February 2018

A long-life, high-capacity, highly safe and wearable solid-state zinc ion battery was constructed using a novel gelatin and PAM based electrolyte.
Dietary intake of glucono-δ-lactone attenuates skin inflammation and contributes to maintaining skin condition
Authors: Kuwano Tetsuya , Kawano Sawako , Kagawa Daiji , Yasuda Yuka , Inoue Yosuke , Murase Takatoshi
Published: February 2018

Skin properties are influenced by both external (e.g., ultraviolet [UV], chemicals, and bacteria) and internal factors (e.g., nutrition and hormones).
Processing of oat: the impact on oat's cholesterol lowering effect
Authors: Grundy Myriam M.-L. , Fardet Anthony , Tosh Susan M. , Rich Gillian T. , Wilde Peter J.
Published: February 2018

Human studies have clearly demonstrated the beneficial impact of consuming oats on cholesterol levels, however, processing can have a significant influence on functionality, which has not yet been fully addressed.
Regioselective addition of DDQ on a quinoid ring: an entry into chiral zwitterionic bridging ligands
Authors: Canard Gabriel , Chen Zhongrui , Suryaningtias Aprilliyani , Jean Marion , Vanthuyne Nicolas , Giorgi Michel , Roussel Christian , Siri Olivier
Published: February 2018

The Michael-type addition of DDQ on a zwitterionic ligand is described together with the chiral separation and full characterization of the two enantiomers of one derivative. These adducts offer a novel entry into chiral zwitterionic quinoidal ligands.
Synthesis, photophysical, DFT and photodiode properties of subphthalocyanine–BODIPY dyads
Authors: Özcan Emrah , Keşan Gürkan , Topaloğlu Burcu , Tanrıverdi Eçik Esra , Dere Ayşegül , Yakuphanoglu Fahrettin , Çoşut Bünyemin
Published: February 2018

In this study, subphthalocyanine–borondipyrromethene conjugates have been successfully designed and synthesized.
Synthesis of thiomers: screening and optimization using chemometrics
Authors: Campos-Requena Víctor H. , Gómez Samuel
Published: February 2018

A chemometric study of the processing variables involved in the synthesis of thiomers based on poly(acrylic acid) functionalized with l-cysteine (PAA-cys) mediated by carbodiimide was successfully carried out.
Synthesis of benzyl hydrazine derivatives via amination of benzylic C(sp3)–H bonds with dialkyl azodicarboxylates
Authors: Samzadeh-Kermani A.
Published: February 2018

Copper(i)/Phen catalysed functionalization of benzylic C–H bonds with dialkyl azodicarboxylates.
A turn-on fluorescence assay of alkaline phosphatase activity using a DNA–silver nanocluster probe
Authors: Ma Changbei , Liu Haisheng , Wu Kefeng , Chen Mingjian , He Hailun , Wang Kemin , Xia Kun
Published: February 2018

A label-free fluorescence assay has been developed for the detection of alkaline phosphatase based on DNA–silver nanocluster probes.
The complexation and thermodynamics of neptunium(v) with acetate in aqueous solution
Authors: Maiwald Martin M. , Skerencak-Frech Andrej , Panak Petra J.
Published: February 2018

The complexation of NpO2+with acetate is studied in aqueous solution by absorption spectroscopy as a function of the total ligand concentration (NaAc), ionic strength (Im= 0.5–4.0 mol kg−1Na+(Cl−/ClO4−)) and temperature (T= 20–85 °C).
Copper nanocluster as a fluorescent indicator for label-free and sensitive detection of DNA hybridization assisted with a cascade isothermal exponential amplification reaction
Authors: Zhang Xingxing , Jin Yan , Li Baoxin
Published: February 2018

A copper nanocluster (CuNCs)-based fluorescence biosensing platform was developed for label-free DNA detection through a cascade isothermal exponential amplification reaction (EXPAR).
Repeated roll-to-roll transfer of two-dimensional materials by electrochemical delamination
Authors: Hempel M. , Lu A.-Y. , Hui F. , Kpulun T. , Lanza M. , Harris G. , Palacios T. , Kong J.
Published: February 2018

We create graphene/graphene and graphene/hBN structures on EVA/PET by R2R processing and analyze the resulting surface morphologies and electrical properties.
Free chargesversusexcitons: photoluminescence investigation of InGaN/GaN multiple quantum well nanorods and their planar counterparts
Authors: Chen Weijian , Wen Xiaoming , Yang Jianfeng , Latzel Michael , Patterson Robert , Huang Shujuan , Shrestha Santosh , Jia Baohua , Moss David J. , Christiansen Silke , Conibeer Gavin
Published: February 2018

Photoexcited carriers are mainly excitons in InGaN/GaN multiple quantum well planar layers while free electron holes are greatly increased in nanorods.
Efficient continuous-wave and short-pulse Ho3+-doped fluorozirconate glass all-fiber lasers operating in the visible spectral range
Authors: Li Wensong , Wu Jiaji , Guan Xiaofeng , Zhou Zhiyong , Xu Huiying , Luo Zhengqian , Cai Zhiping
Published: February 2018

Wavelength-tunable continuous-wave and Q-switching visible Ho3+-doped all-fiber lasers emitting at green and deep-red wavelengths are successfully demonstrated.
Optical emission of GaN/AlN quantum-wires – the role of charge transfer from a nanowire template
Authors: Müßener Jan , Greif Ludwig A. Th. , Kalinowski Stefan , Callsen Gordon , Hille Pascal , Schörmann Jörg , Wagner Markus R. , Schliwa Andrei , Martí-Sánchez Sara , Arbiol Jordi , Hoffmann Axel , Eickhoff Martin
Published: February 2018

One-dimensional GaN quantum-wires grown on nanowire templates exhibit bright and sharp luminescence due to carrier transfer from the nanowire cores.
Nanoarchitectures in dye-sensitized solar cells: metal oxides, oxide perovskites and carbon-based materials
Authors: Shaikh Jasmin S. , Shaikh Navajsharif S. , Mali Sawanta S. , Patil Jyoti V. , Pawar Krishna K. , Kanjanaboos Pongsakorn , Hong Chang Kook , Kim J. H. , Patil Pramod S.
Published: February 2018

Dye-sensitized solar cells (DSSCs) have aroused great interest as a potential renewable energy resource to fulfill the 21stcentury global energy demand.
Synthesis of zwitterionic hydrophilic magnetic mesoporous silica materials for endogenous glycopeptide analysis in human saliva
Authors: Wang Zidan , Wu Runqing , Chen Hemei , Sun Nianrong , Deng Chunhui
Published: February 2018

A novel zwitterionic hydrophilic magnetic mesoporous silica was prepared for endogenous glycopeptide enrichment prior to MS analysis.
A wafer-scale 1 nm Ni(OH)2 nanosheet with superior electrocatalytic activity for the oxygen evolution reaction
Authors: Tian Peng , Yu Yanhao , Yin Xin , Wang Xudong
Published: February 2018

A wafer-scale 1.4 nm Ni(OH)2 nanosheet is fabricated by ionic layer epitaxy and shows orders of magnitude higher electrocatalytic mass activity for OER compared to typical OER catalysts.
Enhanced oxygen reduction of multi-Fe3O4@carbon core–shell electrocatalysts through a nanoparticle/polymer co-assembly strategy
Authors: Zhao Jing , Li Congling , Liu Rui
Published: February 2018

Co-assembly of nanoparticles and block-polymers as a template to fabricate multi-core@shell catalysts with enhanced properties for the oxygen reduction reaction.
Recent advances in anti-angiogenic nanomedicines for cancer therapy
Authors: Bhattarai Pravin , Hameed Sadaf , Dai Zhifei
Published: February 2018

The controlled delivery of nanomedicine-based antiangiogenic inhibitors or chemotherapeutics can revitalize therapeutic success by vessel normalization.
HIV-related DNA detection through switching on hybridized quenched fluorescent DNA-Ag nanoclusters
Authors: Fang Bi-Yun , Li Cheng , An Jie , Zhao Sun-Duo , Zhuang Zhi-Yong , Zhao Yuan-Di , Zhang Yue-Xuan
Published: February 2018

HIV DNA detection through switching on hybridized quenched fluorescent DNA-Ag nanoclusters.
Oxygen self-doped g-C3N4with tunable electronic band structure for unprecedentedly enhanced photocatalytic performance
Authors: Wei Fangyan , Liu Yang , Zhao Heng , Ren Xiaoning , Liu Jing , Hasan Tawfique , Chen Lihua , Li Yu , Su Bao-Lian
Published: February 2018

Oxygen self-doped CNO-xwith tunable electronic band structure demonstrates unprecedentedly enhanced photodegradation of RhB and photocatalytic H2production with excellent stability under visible light.
Exploration of photothermal sensors based on photothermally responsive materials: a brief review
Authors: Xu Suying , Bai Xilin , Wang Leyu
Published: February 2018

Photothermal sensors have emerged as a new type of sensor platform in recent decades and this brief review has summarized different types of photothermally responsive materials and their applications in various fields.
A designable aminophenylboronic acid functionalized magnetic Fe3O4/ZIF-8/APBA for specific recognition of glycoproteins and glycopeptides
Authors: Li Shanshan , Li Dongyan , Sun Long , Yao Yuewei , Yao Cheng
Published: February 2018

We fabricated a novel aminophenylboronic acid functionalized magnetic Fe3O4/zeolitic imidazolate framework-8/APBA (denoted as Fe3O4/ZIF-8/APBA).
Research into the reaction process and the effect of reaction conditions on the simultaneous removal of H2S, COS and CS2 at low temperature
Authors: Sun Xin , Ruan Haotian , Song Xin , Sun Lina , Li Kai , Ning Ping , Wang Chi
Published: February 2018

The removal processes of COS, CS2 and H2S could be divided into two parts: a catalytic hydrolysis reaction and a catalytic oxidation reaction.
Low temperature CO oxidation catalysed by flower-like Ni–Co–O: how physicochemical properties influence catalytic performance
Authors: Yi Yunan , Zhang Pan , Qin Zuzeng , Yu Chuxuan , Li Wei , Qin Qiuju , Li Bin , Fan Minguang , Liang Xin , Dong Lihui
Published: February 2018

The flower-like catalyst possesses highly dispersed amorphous NiO and a high concentration of surface oxygen vacancies which are the central points for CO oxidation.
Amelioration of diethylnitrosamine (DEN)-induced hepatocellular carcinogenesis in animal modelsviaknockdown oxidative stress and proinflammatory markers byMadhuca longifoliaembedded silver nanoparticles
Authors: Singh Deepika , Singh Manvendra , Yadav Ekta , Falls Neha , Komal Ujendra , Dangi Deependra Singh , Kumar Vikas , Verma Amita
Published: February 2018

In hepatocellular carcinoma (HCC), primary liver cancer is primarily responsible for inflammation-related cancer as more than 90% of HCCs emerge with regard to hepatic damage and inflammation.
Novel N-doped ZrO2 with enhanced visible-light photocatalytic activity for hydrogen production and degradation of organic dyes
Authors: Wang Yuanyang , Zhang Yinghua , Lu Haiqiang , Chen Yanxin , Liu Zhenmin , Su Shen , Xue Yongbing , Yao Jianfeng , Zeng Hongbo
Published: February 2018

Two new types of N-doped ZrO2 photocatalysts ZON and AZON have been synthesized using ethylenediamine as the nitrogen source by a facile and low-cost sol–gel method.
Building nanogapped graphene electrode arrays by electroburning
Authors: Gu Chunhui , Su Dingkai , Jia Chuancheng , Ren Shizhao , Guo Xuefeng
Published: February 2018

An approach for the efficient fabrication of graphene nanoelectrodes through the combination of dash-line lithography and electroburning is demonstrated in detail.
Insights into non-noble metal based nanophotonics: exploration of Cr-coated ZnO nanorods for optoelectronic applications
Authors: Dixit Tejendra , Palani I. A. , Singh Vipul
Published: February 2018

Herein, the room temperature photoluminescence and Raman spectra of hydrothermally grown ZnO nanorods coated with Cr are investigated for optoelectronic applications.
Mobility enhancement for high stability tungsten-doped indium-zinc oxide thin film transistors with a channel passivation layer
Authors: Ruan Dun-Bao , Liu Po-Tsun , Chiu Yu-Chuan , Kuo Po-Yi , Yu Min-Chin , Gan Kai-jhih , Chien Ta-Chun , Sze Simon M.
Published: February 2018

This study investigates the electrical characteristics and physical analysis for an amorphous tungsten-doped indium-zinc oxide thin film transistor with different backchannel passivation layers, which were deposited by an ion bombardment-free process.
Stability and electronic structure of hydrogen vacancies in ADP: hybrid DFT with vdW correction
Authors: Sui Tingting , Lian Yafei , Xu Mingxia , Zhang Lisong , Li Yanlu , Zhao Xian , Sun Xun
Published: February 2018

Hybrid DFT calculations with vdW correction well explain the defect-induced conductivity break of ADP in the high-temperature region.
A novel biocompatible zwitterionic polyurethane with AIE effect for cell imaging in living cells
Authors: Xu Junhuai , Yan Rui , Wang Haibo , Du Zongliang , Gu Jun , Cheng Xu , Xiong Junjie
Published: February 2018

In this work, a novel and stable zwitterionic polymer (TPE-CB PUs) was prepared to realize a cellular imaging system.
Triple network hydrogels (TN gels) prepared by a one-pot, two-step method with high mechanical properties
Authors: Wang Xiangong , Zhao Fang , Pang Bo , Qin Xuping , Feng Shengyu
Published: February 2018

TN hydrogels with high mechanical properties are prepared and they have potential application in biomaterials.
Cu-catalyzed mild and efficient oxidation of THβCs using air: application in practical total syntheses of perlolyrine and flazin
Authors: Zheng Bo , Trieu Tien Ha , Meng Tian-Zhuo , Lu Xia , Dong Jing , Zhang Qiang , Shi Xiao-Xin
Published: February 2018

A mild, efficient and ecofriendly method for synthesis of β-carbolines via Cu-catalyzed aerobic oxidation of 1,2,3,4-tetrahydro-β-carbolines (THβCs) was developed. In addition, this method was successfully applied in the practical total syntheses of perlolyrine and flazin.
Desymmetrisation of meso-diones promoted by a highly recyclable polymer-supported chiral phosphoric acid catalyst
Authors: Clot-Almenara Lidia , Rodríguez-Escrich Carles , Pericàs Miquel A.
Published: February 2018

A polystyrene-supported, recyclable, BINOL-derived chiral phosphoric acid has been applied to the desymmetrization of meso-diones to produce enantioenriched cyclohexenones.
An efficient and sensitive chemosensor based on salicylhydrazide for naked-eye and fluorescent detection of Zn2+
Authors: Shi Zhanglin , Tu Yayi , Pu Shouzhi
Published: February 2018

A naked-eye and fluorescent detector for Zn2+ was synthesized by the combination of salicylhydrazide and diarylethene with good photochromic properties.
Connecting the solution chemistry of PbI2 and MAI: a cyclodextrin-based supramolecular approach to the formation of hybrid halide perovskites
Authors: Masi Sofia , Aiello Federica , Listorti Andrea , Balzano Federica , Altamura Davide , Giannini Cinzia , Caliandro Rocco , Uccello-Barretta Gloria , Rizzo Aurora , Colella Silvia
Published: February 2018

Cyclodextrin macrocycles are able to modify and control the solvation equilibria of hybrid perovskite components in solution by establishing supramolecular interactions.
In situ diffraction studies on reversible oxygen uptake and release in AFe2O4 + δ (A= Lu, Yb, Y, and In)
Authors: Jayathilake R. S. , Levitas B. D. , Rodriguez E. E.
Published: February 2018

We have studied the reversible uptake and release of oxygen in the layered metal oxide system AB2O4 for A = Lu, Yb, Y, and In to understand their suitability as oxygen storage materials.
Dithienosilole-based non-fullerene acceptors for efficient organic photovoltaics
Authors: Zhang Zhongbo , Zhu Xiaozhang
Published: February 2018

The obtained PCE of 9.60% is so far the best performance reported for OPV devices utilizing dithienosilole-based organic photovoltaic materials.
A high voltage cathode of Na2+2xFe2−x(SO4)3intensively protected by nitrogen-doped graphene with improved electrochemical performance of sodium storage
Authors: Wang Wei , Liu Xiaohao , Xu Qunjie , Liu Haimei , Wang Yong-Gang , Xia Yongyao , Cao Yuliang , Ai Xinping
Published: February 2018

A high voltage alluaudite sulfate Na2+2xFe2−x(SO4)3composited with nitrogen-doped graphene and the sodium storage performance is remarkably improved.
Mechanically robust and high-performance ternary solar cells combining the merits of all-polymer and fullerene blends
Authors: Lee Wonho , Kim Jae-Han , Kim Taesu , Kim Seonha , Lee Changyeon , Kim Jin-Seong , Ahn Hyungju , Kim Taek-Soo , Kim Bumjoon J.
Published: February 2018

In this work, we present a facile strategy that combines the merits of both fullerene-PSCs and all-PSCs to significantly increase the PCE of the all-PSCs without compromising mechanical performance.
Nanoinitiator for enzymatic anaerobic polymerization and graft enhancement of gelatin–PAAM hydrogel
Authors: Zhang Qi , Lv Yanan , Liu Mingyu , Wang Xia , Mi Yongli , Wang Qigang
Published: February 2018

We mildly fabricate gelatin-poly(acrylamide) hydrogel integrating the ingenious design of nanoinitiators with glucose oxidase radical polymerization.
Thermo-responsive photoluminescent silver clusters/hydrogel nanocomposites for highly sensitive and selective detection of Cr(vi)
Authors: Shen Xiran , Yang Xudong , Su Chunyan , Yang Jinghua , Zhang Long , Liu Binghui , Gao Siyu , Gai Fangyuan , Shao Zhubao , Gao Guanghui
Published: February 2018

A photoluminescent sensor was fabricated. The PL intensity of the composite exhibited a linear and reversible response from 2 to 85 °C and showed high PL quenching for sensitive detection of Cr(vi).
Thermally activated delayed fluorescence material with aggregation-induced emission properties for highly efficient organic light-emitting diodes
Authors: Zhao Yaodong , Wang Weigao , Gui Chen , Fang Li , Zhang Xinlei , Wang Shujuan , Chen Shuming , Shi Heping , Tang Ben Zhong
Published: February 2018

Luminescent materials with aggregation-induced emission (AIE) properties exhibit high solid state emission, while thermally activated delayed fluorescence (TADF) materials can fully harvest singlet and triplet excitons to achieve efficient electroluminescence (EL).
Cool-SPS: an opportunity for low temperature sintering of thermodynamically fragile materials
Authors: Herisson de Beauvoir Thomas , Sangregorio Anna , Cornu Iñaki , Elissalde Catherine , Josse Michael
Published: February 2018

Sintering has been achieved by Spark Plasma Sintering at low temperatures (<400 °C) and relatively high pressures (300 to 600 MPa) for various thermodynamically fragile compounds (carbonates, sulfate, and phosphate) decomposing between 220 and 780 °C.
Target-responsive DNA hydrogel for non-enzymatic and visual detection of glucose
Authors: Ma Yanli , Mao Yu , An Yuan , Tian Tian , Zhang Huimin , Yan Jinmao , Zhu Zhi , Yang Chaoyong James
Published: February 2018

A glucose responsive DNA hydrogel was developed for the visual detection of glucose.
A guanidinium ionic liquid-based surfactant as an adequate solvent to separate and preconcentrate cadmium and copper in water using in situ dispersive liquid–liquid microextraction
Authors: Khiat Meriem , Pacheco-Fernández Idaira , Pino Verónica , Benabdallah Tayeb , Ayala Juan H. , Afonso Ana M.
Published: February 2018

A guanidinium ionic liquid-based surfactant to preconcentrate cadmium and copper in water using in situ dispersive liquid–liquid microextraction.
A sulfonated chitooligosaccharide modified silica material for hydrophilic interaction liquid chromatography and its chromatographic evaluation
Authors: Yan Kui , Yang Haiyan , Huang Shaohua , Bai Zhengwu
Published: February 2018

A sulfonated chitooligosaccharide modified silica material was successfully prepared and displayed excellent selectivity and efficient retention in HILIC mode.
Authenticity assessment of anabolic androgenic steroids in counterfeit drugs by1H NMR
Authors: Ribeiro Marcos Vinícius de M. , Boralle Nivaldo , Pezza Helena R. , Pezza Leonardo
Published: February 2018

Simple, fast, and selective drug authenticity verification using1H NMR.
A new and simple electroanalytical method to detect thiomersal in vaccines on a screen-printed electrode modified with chitosan
Authors: Gonzalez Camila , García-Beltrán Olimpo , Nagles Edgar
Published: February 2018

The use of a screen-printed electrode modified with chitosan (Cs) to determine thiomersal (TMS) through the oxidation of thiosalicylic acid by linear sweep anodic stripping voltammetry is reported for the first time in this work.
Dual signal amplification strategy for high-sensitivity detection of copper species in bio-samples with a tunable dynamic range
Authors: Xiong Yamin , Meng Peijun , Li Huiling , Hu Yue , Zhou Lihong , Jiang Shuqin , Pang Yuanfeng , Li Shujuan , Huang Peili
Published: February 2018

A facile method was constructed and applied to detection of copper species in bio-samples with a tunable dynamic range.
A novel panchromatic shutter based on an ambipolar electrochromic system without supporting electrolyte
Authors: Wu Jung-Tsu , Liou Guey-Sheng
Published: February 2018

A novel panchromatic ambipolar electrochromic device without additional supporting electrolyte was fabricated successfully, and demonstrates high color contrast over the visible light region, fast switching time, and excellent long-term stability.
Templated synthesis of atomically-thin Ag nanocrystal catalysts in the interstitial space of a layered silicate
Authors: Doustkhah Esmail , Rostamnia Sadegh , Tsunoji Nao , Henzie Joel , Takei Toshiaki , Yamauchi Yusuke , Ide Yusuke
Published: February 2018

Enclosing functional nanoparticles in stable inorganic supports is important for generating ultra-stable catalytic active sites with good performance and material utilization efficiency.
Tetrabenzo-Chichibabin's hydrocarbons: substituent effects and unusual thermochromic and thermomagnetic behaviours
Authors: Jiang Chuanling , Bang Yawen , Wang Xinhao , Lu Xuefeng , Lim Zhenglong , Wei Haipeng , El-Hankari Samir , Wu Jishan , Zeng Zebing
Published: February 2018

A series of new Chichibabin's hydrocarbons was studied, and a cationic ammonium substituted product was obtained, showing unusual thermochromic and thermomagnetic behaviours.
Sensitive detection of alkaline phosphatase by dephosphorylation-initiated transcription reaction-mediated dual signal amplification
Authors: Ma Fei , Liu Wen-jing , Liang Li , Tang Bo , Zhang Chun-Yang
Published: February 2018

We develop a new fluorescence method for the sensitive detection of alkaline phosphatase based on dephosphorylation-initiated transcription reaction-mediated dual signal amplification.
Engineering oxygen vacancies through construction of morphology maps for bio-responsive nanoceria for osteosarcoma therapy
Authors: Mehmood Rashid , Wang Xiaochun , Koshy Pramod , Yang Jia Lin , Sorrell Charles C.
Published: February 2018

The present work provides guidelines for the engineering of oxygen vacancy concentrations using morphology-maps based on the characteristics of nanoceria (CeO2−x) nanocubes, nanorods, and truncated nanooctahedra.
Morphology-selective synthesis of Cu(NO3)2·2.5H2O micro/nanostructures achieved by rational manipulation of nucleation pathways and their morphology-preserved conversion to CuO porous micro/nanostructures
Authors: Feng Feng , Chen Muzi , Wu Ji Hong
Published: February 2018

A special Cu(NO3)2 thin solution layer was built on highly hydrophilic mica surfaces and subjected to rapid evaporation. Controlling the evaporation time can intentionally manipulate the supersaturation.
A highly porous acylamide decorated MOF-505 analogue exhibiting high and selective CO2 gas uptake capability
Authors: Zheng Baishu , Huang Lu , Cao Xiyang , Shen Shaohua , Cao Haifei , Hang Cheng , Zeng Wenjiang , Wang Zhaoxu
Published: February 2018

A highly porous acylamide decorated MOF-505 analogue with optimized pores, open copper sites and acylamide groups exhibits large and selective CO2 adsorption over CH4 and N2 under ambient conditions.
Correction: Diversified polyoxovanadate derivatives obtained by copper(i)-catalysed azide–alkyne cycloaddition reaction: their synthesis and structural characterization
Authors: Jia Hongli , Li Qi , Bayaguud Aruuhan , Huang Yichao , She Shan , Chen Kun , Wei Yongge
Published: February 2018

Correction for ‘Diversified polyoxovanadate derivatives obtained by copper(i)-catalysed azide–alkyne cycloaddition reaction: their synthesis and structural characterization’ by Hongli Jia et al., Dalton Trans., 2018, 47, 577–584.
Advanced treatment of hydrothermal liquefaction wastewater with nanofiltration to recover carboxylic acids
Authors: Zhang Xuesong , Scott John , Sharma Brajendra K. , Rajagopalan Nandakishore
Published: February 2018

Advances in HTL wastewater treatment using nanofiltration technology to recover carboxylic acids.
4-(2-Pyridylazo)-resorcinol-functionalized polyacrylonitrile fiber through a microwave irradiation method for the simultaneous optical detection and removal of heavy metals from water
Authors: Deng Sheng , Zhang GuangShan , Wang Peng
Published: February 2018

A PAR-functionalized fiber by microwave irradiation has both colorimetric detection and adsorption abilities for heavy metal ions.
Graphene oxide size and oxidation degree govern its supramolecular interactions with siRNA
Authors: Reina Giacomo , Chau Ngoc Do Quyen , Nishina Yuta , Bianco Alberto
Published: February 2018

We systematically studied the interactions between graphene oxide (GO) and siRNA. The siRNA secondary structure is damaged by the interaction with GO sheets. Functionalization of GO with polyethyleneimine is able to protect siRNA from structural modifications.
KI-catalyzed C–S bond formation via an oxidation relay strategy: efficient access to various α-thio-β-dicarbonyl compounds
Authors: Jiang Yi , Zou Jiao-Xia , Huang Long-Tao , Peng Xue , Deng Jie-Dan , Zhu Long-Qing , Yang Yu-Hang , Feng Yi-Yue , Zhang Xiao-Yun , Wang Zhen
Published: February 2018

An efficient and practical methodology to obtain α-thio-β-dicarbonyl compounds was presented under alkaline conditions via potassium iodide (KI) catalysis.
Correction: Highly sensitive, durable and stretchable plastic strain sensors using sandwich structures of PEDOT:PSS and an elastomer
Authors: Fan Xi , Wang Naixiang , Wang Jinzhao , Xu Bingang , Yan Feng
Published: February 2018

Correction for ‘Highly sensitive, durable and stretchable plastic strain sensors using sandwich structures of PEDOT:PSS and an elastomer’ by Xi Fan et al., Mater. Chem. Front., 2018, 2, 355–361.
12-Molybdophosphoric acid anchored on aminopropylsilanized magnetic graphene oxide nanosheets (Fe3O4/GrOSi(CH2)3–NH2/H3PMo12O40): a novel magnetically recoverable solid catalyst for H2O2-mediated oxidation of benzylic alcohols under solvent-free conditions
Authors: Farhadi Saeed , Hakimi Mohammad , Maleki Mansoureh
Published: February 2018

12-Molybdophosphoric acid was anchored on magnetic aminopropylsilanized graphene oxide nanosheets and used as a magnetically recoverable catalyst for solvent-free selective oxidation of benzylic alcohols into the carbonyl compounds with H2O2.
Super electron donors derived from diboron
Authors: Zhang Li , Jiao Lei
Published: February 2018

The combination of diboron, pyridine and base serves as an efficient source of structurally well-defined super electron donors.
High-throughput theoretical optimization of the hydrogen evolution reaction on MXenes by transition metal modification
Authors: Li Pengkun , Zhu Jinguo , Handoko Albertus D. , Zhang Ruifeng , Wang Haotian , Legut Dominik , Wen Xiaodong , Fu Zhongheng , Seh Zhi Wei , Zhang Qianfan
Published: February 2018

Electrocatalysis has the potential to become a more sustainable approach to generate hydrogen as a clean energy source and chemical feedstock.
A pre-constructed graphene–ammonium polyphosphate aerogel (GAPPA) for efficiently enhancing the mechanical and fire-safety performances of polymers
Authors: Wang Lei , Wu Shuhong , Dong Xiangyu , Wang Rui , Zhang Liqiang , Wang Jianlei , Zhong Jie , Wu Lixin , Wang Xin
Published: February 2018

Using modified 3D GAs as reinforcing additives is a feasible way to combine excellent mechanical enhancement with great fire-safety performances.
Concurrent enhancement in the H2 and UV sensing properties of ZnO nanostructures through discontinuous lattice coating of La3+via partial p–n junction formation
Authors: Kathiravan Deepa , Huang Bohr-Ran
Published: February 2018

A discontinuous lanthanum (La3+)-coated ZnO nanorod-based multisensor was fabricated for the first time. The H2 gas and UV sensing properties were studied simultaneously.
Interface dipole for remarkable efficiency enhancement in all-solution-processable transparent inverted quantum dot light-emitting diodes
Authors: Chen Lixiang , Lee Min-Hsuan , Wang Yiwen , Lau Ying Suet , Syed Ali Asgher , Zhu Furong
Published: February 2018

We report our efforts to develop high performing all-solution-processable transparent inverted QD-LEDs by interposing an interface dipole between the ZnO ETL and the quantum dot light-emitting layer.
Mechanical strain engineering of dielectric tunability in polycrystalline SrTiO3 thin films
Authors: Tkach Alexander , Okhay Olena , Reaney Ian M. , Vilarinho Paula Maria
Published: February 2018

Relative permittivity, εr, and dielectric tunability, η, of polycrystalline ST films optimised via compressive stresses, ex: ST films on MgO/Pt substrates.
Metabolic profiling of visceral adipose tissue from obese subjects with or without metabolic syndrome
Authors: Candi Eleonora , Tesauro Manfredi , Cardillo Carmine , Lena Anna Maria , Schinzari Francesca , Rodia Giuseppe , Sica Giuseppe , Gentileschi Paolo , Rovella Valentina , Annicchiarico-Petruzzelli Margherita , Di Daniele Nicola , Melino Gerry
Published: February 2018

Obesity represents one of the most complex public health challenges and has recently reached epidemic proportions. Obesity is also considered to be primarily responsible for the rising prevalence of metabolic syndrome, defined as the coexistence in the same individual of several risk factors for atherosclerosis, including dyslipidemia, hypertension and hyperglycemia, as well as for cancer. Additionally, the presence of three of the five risk factors (abdominal obesity, low high-density lipoprotein cholesterol, high triglycerides, high fasting glucose and high blood pressure) characterizes metabolic syndrome, which has serious clinical consequences. The current study was conducted in order to identify metabolic differences in visceral adipose tissue (VAT) collected from obese (body mass index 43–48) human subjects who were diagnosed with metabolic syndrome, obese individuals who were metabolically healthy and nonobese healthy controls. Extensive gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS/MS) analyses were used to obtain the untargeted VAT metabolomic profiles of 481 metabolites belonging to all biochemical pathways. Our results indicated consistent increases in oxidative stress markers from the pathologically obese samples in addition to subtle markers of elevated glucose levels that may be consistent with metabolic syndrome. In the tissue derived from the pathologically obese subjects, there were significantly elevated levels of plasmalogens, which may be increased in response to oxidative changes in addition to changes in glycerolphosphorylcholine, glycerolphosphorylethanolamine glycerolphosphorylserine, ceramides and sphingolipids. These data could be potentially helpful for recognizing new pathways that underlie the metabolic–vascular complications of obesity and may lead to the development of innovative targeted therapies.
Image processing for cryogenic transmission electron microscopy of symmetry-mismatched complexes
Authors: Huiskonen Juha T.
Published: February 2018

Cryogenic transmission electron microscopy (cryo-TEM) is a high-resolution biological imaging method, whereby biological samples, such as purified proteins, macromolecular complexes, viral particles, organelles and cells, are embedded in vitreous ice preserving their native structures. Due to sensitivity of biological materials to the electron beam of the microscope, only relatively low electron doses can be applied during imaging. As a result, the signal arising from the structure of interest is overpowered by noise in the images. To increase the signal-to-noise ratio, different image processing-based strategies that aim at coherent averaging of signal have been devised. In such strategies, images are generally assumed to arise from multiple identical copies of the structure. Prior to averaging, the images must be grouped according to the view of the structure they represent and images representing the same view must be simultaneously aligned relatively to each other. For computational reconstruction of the 3D structure, images must contain different views of the original structure. Structures with multiple symmetry-related substructures are advantageous in averaging approaches because each image provides multiple views of the substructures. However, the symmetry assumption may be valid for only parts of the structure, leading to incoherent averaging of the other parts. Several image processing approaches have been adapted to tackle symmetry-mismatched substructures with increasing success. Such structures are ubiquitous in nature and further computational method development is needed to understanding their biological functions.
Genome-wide differential expression profiling of mRNAs and lncRNAs associated with prolificacy in Hu sheep
Authors: Feng Xu , Li Fengzhe , Wang Feng , Zhang Guomin , Pang Jing , Ren Caifang , Zhang Tingting , Yang Hua , Wang Ziyu , Zhang Yanli
Published: February 2018

Reproductive ability, especially prolificacy, impacts sheep profitability. Hu sheep, a unique Chinese breed, is recognized for its high prolificacy (HP), early sexual maturity, and year-round estrus. However, little is known about the molecular mechanisms underlying HP in Hu sheep. To explore the potential mRNAs and long non-coding RNAs (lncRNAs) involved in Hu sheep prolificacy, we performed an ovarian genome-wide analysis of mRNAs and lncRNAs during the follicular stage using Hu sheep of HP (litter size = 3; three consecutive lambings) and low prolificacy (LP, litter size = 1; three consecutive lambings). Plasma luteinizing hormone (LH) concentration was higher in the HP group than in the LP group (P<0.05) during the follicular stage. Subsequently, 76 differentially expressed mRNAs (DE-mRNAs) and five differentially expressed lncRNAs (DE-lncRNAs) were identified by pairwise comparison; quantitative real-time PCR (qRT-PCR) analysis of ten randomly selected DE genes (mRNA and lncRNA) were consistent with the sequencing results. Gene Ontology (GO) analysis of DE-mRNAs revealed significant enrichment in immune response components, actin filament severing and phagocytosis. Pathway enrichment analysis of DE-mRNAs indicated a predominance of immune function pathways, including phagosomes, lysosomes, and antigen processing. We constructed a co-expression network of DE-mRNAs and mRNA-lncRNAs, with C1qA, CD53, cathepsin B (CTSB), CTSS, TYROBP, and AIF1 as the hub genes. Finally, the expression of lysosomal protease cathepsin genes, CTSB and cathepsin D (CTSD), were significantly up-regulated in sheep ovaries in the HP group compared with the LP group (P<0.05). These differential mRNAs and lncRNAs may provide information on the molecular mechanisms underlying sheep prolificacy.