bluuebunny/crossref_metadata_2025 huggingface dataset:
L’espace de navigation du chaland et la question de son armement
Authors: Marlier Sabrina
Published: January 2018

The zone of transport geography of the barge and the question of its outfitting.

While the form of the Arles-Rhône 3 barge seems to fit perfectly the demands of navigation in a strong current, as is found upstream from Arles, its limited load capacity tends to set it within a local economic circuit, in keeping with what we know of its final voyage. Sailing on the lower section of the Rhône, one can imagine the barge being involved in a regular turnaround of goods transport : construction material or any other heavy stuff when heading downstream, and a lighter load, such as livestock (goats and/ or sheeps), grain, salt or bales of wool, when returning upstream from the Camargue. The questions of the outfitting of the barge and of the organisation of its navigation on the river are, however, still unanswered. Likewise, it is impossible to answer the questions about chartering agreements and one can imagine the possibility of a public contractor, with the barge involved in “ public sector work”, or of private contractor, perhaps a (land) owner from Arles. Despite the challenges raised by the Arles-Rhône 3 barge and the various theories that can be put forward, the study of this barge in the end asks the more general question about the economy of water transport on the Rhône in the Roman era. Thus, regarding the transport of materials and other goods on the river, one can imagine a fleet of boats, especially barges, moving up and down stream on more or less short reaches of the river as a function of economic interests and the architectural nature of the boats, and according to the rhythm of the river. There would appear much to be written about the subject.
A complex hierarchical quorum-sensing circuitry modulates phenazine gene expression in Pseudomonas aeruginosa
Authors: Abd El-Aziz Norhan Khairy , Abd El-Hamid Marwa Ibrahim , El-Naenaeey El-sayed Youssef
Published: January 2018

Introduction: Pseudomonas aeruginosa (P. aeruginosa) modulates the expression of a myriad of virulence factors via two complicated hierarchical quorum-sensing (QS) cascade. This study shed light on the interrelation between P. aeruginosa QS systems and pyocyanin production.

Methodology: Transcription analysis of lasR, rhlR, rhlI and phz genes using quantitative real time-reverse transcriptase PCR (qRT–PCR) assay, followed by sequencing of the autoinducer synthase (lasI gene) were applied for 15 P. aeruginosa strains recovered from diverse animal clinical sources.

Results: Expression studies revealed that most P. aeruginosa strains demonstrated statistically significant differences (p < 0.05) with a very wide range of transcript levels of QS and phz genes in comparison to P. aeruginosa ATCC 27853. We have identified significant positive correlations (r ≥ 0.3) between the expressions of QS and phz genes in eleven analyzed strains, whereas pyocyanin production positively correlated with the expression of lasR only in three strains (r ≥ 0.6). We further found that there was a negative correlation between the transcript levels of QS and phz genes in one bacterial strain. Analysis of lasI sequences showed point mutations explaining the alterations in pyocyanin expression. The deficiencies of lasI, lasR and rhlI with rhlR-dependent expression of phz in one strain were also recorded.

Conclusions: These results provided new insights to the pivotal role of QS signal molecules on pyocyanin production presenting the las system as the dominant regulator.
Le double étranger : une configuration du lien et de l’identité
Authors: Drweski Philippe
Published: January 2018

À partir d’une pratique clinique dans des groupes accueillants des patients migrants, je tente d’appréhender la façon spécifique dont la question de l’étranger peut émerger et être traitée au sein de deux dispositifs : un groupe à médiation sensorielle ainsi qu’un psychodrame. Mon hypothèse est que l’étranger est une composante essentielle de l’identité et que ces groupes qui utilisent des canaux complémentaires à la parole sont des lieux de traitement indiqués pour cette clinique. À partir de l’analyse du matériel recueilli selon une méthode d’observation et de prise de notes, il apparaît que cette hypothèse se vérifie mais selon une modalité particulière. L’analyse montre que l’étranger a des effets psychiques sur le groupe (angoisses, mécanismes de défense…). Nous découvrons ici qu’une modalité de traitement consiste à l’utilisation de la représentation du double. C’est par la médiatisation de cette figure que l’étranger peut s’intégrer et devenir familier. Nous arrivons ainsi à la conclusion d’une co-figuration d’un double étranger comme l’incarnation dialectique de l’identité.
El libro de los Proverbios como fuente sapiencial: nuevos datos sobre la difusión de los romanceamientos bíblicos castellanos de origen judío
Authors: Sainz de la Maza Carlos N.
Published: January 2018

El estudio comparativo de las citas bíblicas incluidas en las obras literarias medievales, en especial las de tipo didáctico-moral y las de polémica religiosa, es un instrumento útil para intentar aproximarse a los procesos de difusión de las biblias romanceadas castellanas. Analizamos aquí la significativa relación existente entre los versículos del libro de los Proverbios incluidos en la obra sapiencial Palabras breves, dichos de sabios y dicho corpus bíblico.
Fragmento de biblia romanceada reutilizada como cubierta de un legajo procedente del Monasterio de Santa María de La Sisla
Authors: Avenoza Gemma
Published: January 2018

Durante siglos, los bifolios de pergamino de manuscritos que por una u otra razón habían dejado de ser útiles, fueron reaprovechados para encuadernaciones. En Madrid, en un fondo monástico sin catalogar del Archivo Histórico Nacional, he localizado uno de esos membra disiecta que procede de una biblia en romance copiada en el s. XV. Se trata de un fragmento de la traducción del hebreo al castellano transmitida por Esc. I-I-3. En este artículo presento un análisis codicológico de este nuevo testimonio y avanzo una hipótesis sobre su procedencia. El estudio se completa con una transcripción paleográfica del texto.
Cinesioterapia e eletroestimulação na incontinência urinária feminina/ Kinesiotherapy and electrostimulation in female urinary incontinence
Authors: Brandenburg Cristine , Fialho Lia Machado Fiuza , Baron Miriam Viviane , Martins Aline Barbosa Texeira
Published: January 2018

A incontinência urinária é definida como qualquer perda urinária involuntária e constitui um problema social e higiênico. O objetivo do estudo foi analisar a eficácia de tratamento fisioterapêutico na reeducação da musculatura do assoalho pélvico de mulheres com incontinência urinária por meio da cinesioterapia versus eletroestimulação. Trata-se de estudo quase experimental realizado na clínica FisioUNISC entre outubro de 2007 e maio de 2008. O estudo avaliou a força de contração da musculatura perineal em 36 mulheres por intermédio do perineômetro digital, do teste do absorvente e do questionário de qualidade de vida - King’s Health Questionnaire (KHQ). A terapêutica foi constituída de dois grupos distintos: o primeiro realizava a cinesioterapia; o segundo, a eletroestimulação. Cada grupo concretizou 20 sessões de tratamento, realizado três vezes por semana. Mediante o teste do absorvente, constatou-se a redução na perda de urina e o consecutivo progresso da força de contração vaginal nos dois grupos investigados, com a cinesioterapia exprimindo melhor resultado. O KHQ evidenciou resultados similares, com melhora na pontuação para os dois grupos, destacando maior pontuação no grupo da cinesioterapia. Os resultados mostraram melhora do quadro de incontinência urinária com os dois tratamentos, contudo a cinesioterapia se mostrou a opção mais efetiva.
PERSPECTIVAS DE FORMAÇÃO DOCENTE: O PROGRAMA INSTITUCIONAL DE BOLSAS DE INICIAÇÃO À DOCÊNCIA (PIBID) COMO POLÍTICA PÚBLICA
Authors: Hemielewski Dulce Maria de Souza , Pacheco Luci Mary Duso , Jung Hildegard Susana
Published: January 2018

O presente artigo tem o objetivo de relatar os resultados de uma pesquisa em nível de pós-graduação stricto sensu voltada a analisar os impactos do Programa Institucional de Bolsas de Iniciação à Docência (Pibid) como política de formação docente. Tratou-se de uma pesquisa qualitativa ancorada nos princípios da concepção filosófica hermenêutica, com fins descritivos e exploratórios. A coleta dos dados empíricos ocorreu por meio de entrevista semiestruturada realizada com 10 professores das disciplinas pedagógicas do ensino médio – Curso Normal, no período de 2013 a 2016. Os resultados apontam para a grande valia do Programa para a qualificação da formação docente, uma vez que proporciona um espaço de reflexão para os bolsistas acadêmicos, bem como para os supervisores professores e alunos da escola/campo de pesquisa, aproximando os estudos da universidade à realidade das escolas de educação básica. Políticas como o Pibid permitem a compreensão e a reflexão sobre as práticas adotadas no fazer pedagógico, as quais qualificam as ações utilizadas em sala de aula, bem como os relacionamentos que se instauram nesses espaços escolares.
Gas Nitriding and Oxidation of Ti-6Al-4V Alloy
Authors: Lee Dong Bok , Abro Waheed Ali , Lee Kun Sang , Abro Muhammad Ali , Pohrelyuk Iryna , Yaskiv Oleh
Published: January 2018

The Ti-6Al-4V alloy was nitrided at 950 °C for 8 h by heating under atmospheric nitrogen in order to improve its surface hardness and oxidation resistance. Nitrogen diffused into the Ti6Al4V alloy, and formed ~40 μm-thick coating consisting of TiN as the major phase and Ti2N as the minor one. Nitriding increased the surface microhardness through the strengthening effect of interstitial nitrogen and the formation of nitrides. Oxidation at 700 °C for 10 h formed a superficial TiO2 layer on the coating.
The Formation and Migration Energy of Bivacancy in fcc Metals
Authors: Poletaev Gennady M. , Zorya Irina V. , Starostenkov Mikhail D.
Published: January 2018

In the work we propose a method for determining of the formation energy of bivacancy using molecular dynamics method. The key moment of the method for determining of the formation energy of bivacancy is the use of the value ζ, the minimum work that must be spent to remove one atom to infinity from the kink in the monatomic step on the surface of the crystal, calculated indirectly through the experimental data on the formation energy of the vacancy and the sublimation energy. The energy of migration of bivacancy in the work was determined from the temperature dependence of the diffusion coefficient when one bivacancy was introduced into the calculation block.
Biphase Model of Plastic Deformation in Electric Fields
Authors: Sarychev Vladimir D. , Nevskii Sergey A. , Semin Alexander P. , Gromov Victor E.
Published: January 2018

The object of the research is creep deformation proceeding in the conditions of electrostatic field effect. The purpose of the research is to develop the mathematical model of creep under the electrostatic field effect from the positions of representations about the wave nature of plastic deformation process. The theoretical studies of electrostatic field effect being characterized by small (up to ± 1V) potentials on the basis of mass, momentum and energy conservation in two-dimensional formulation were carried out in the process of research. The material being deformed was represented as two phase heterogeneous medium. The first component is excited and being responsible for structure transformation, the second one is unexcited and disconnected with them. For each of the components the laws of mass and momentum conservation were written. For electric fields the Maxwell equations were written. For the first time the two phase filtration model of creep was developed as a result of the research. The model takes into account the inhomogeneity of plastic deformation under electrostatic field effect. The dispersion relation for the waves of plasticity is obtained.
Cutting Edge: Homeostasis of Innate Lymphoid Cells Is Imbalanced in Psoriatic Arthritis
Authors: Soare Alina , Weber Stefanie , Maul Lisa , Rauber Simon , Gheorghiu Ana Maria , Luber Markus , Houssni Ismail , Kleyer Arnd , von Pickardt Gero , Gado Manuel , Simon David , Rech Jürgen , Schett Georg , Distler Jörg H. W. , Ramming Andreas
Published: January 2018

Innate lymphoid cells (ILC) have a high potency for cytokine production independent of specific Ag stimulation. Imbalance of ILC subsets may influence cytokine production in humans and hence be associated with the development of inflammatory disease. Evidence for an imbalance of ILC homeostasis in human disease, however, is very limited to date. In this study we show that psoriatic arthritis (PsA), a severe disease of the joints depending on the activation of the IL-23/IL-17 pathway, is characterized by a skewed ILC homeostasis. Circulating ILC3s as potent source of IL-17/IL-22 were elevated in active PsA, whereas ILC2s, which produce proresolving cytokines, were decreased. The ILC2/ILC3 ratio was significantly correlated with clinical disease activity scores and the presence of imaging signs of joint inflammation and bone damage. Multivariable analysis showed that a high ILC2/ILC3 ratio is associated with remission in PsA, suggesting that specific alterations of ILC homeostasis control disease activity in PsA.
Betaine Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Dendritic Cell–Derived IL-6 Production and Th17 Differentiation
Authors: Yang Cuixia , Lai Weiming , Zhou Jinfeng , Zheng Xinyuan , Cai Yingying , Yang Wanjie , Xie Sirong , Gao Yuan , Du Changsheng
Published: January 2018

IL-17–secreting T cells (Th17 cells) play a pathogenic role in multiple autoimmune diseases, including multiple sclerosis (MS), and dendritic cell (DC)-derived cytokines play pivotal roles in promoting the differentiation of naive CD4+ T cells into Th cell subsets (Th1 and Th17). Therefore, small molecules blocking the key cytokines produced by DCs will be beneficial in MS. In this article, we report that betaine treatment ameliorates MS pathogenesis by inhibiting DC-derived IL-6 production and Th17 differentiation. Using experimental autoimmune encephalomyelitis, a widely used mouse model of MS, we found that, compared with the vehicle-treated group, betaine-treated mice exhibited less severe experimental autoimmune encephalomyelitis symptoms, including lower clinical scores, reduced leukocyte infiltration, and less extensive demyelination in the CNS. Moreover, a significantly lower percentage of Th17 cells, one of the major pathogenic effector cells in MS progression, was observed in the peripheral immune system and in the CNS. Interestingly, in the in vitro Th17-differentiation assay, no significant change in Th17 cells was observed between the vehicle- and betaine-treated groups, whereas in the in vitro DC culture experiment, betaine treatment significantly decreased DC-derived IL-6 production. In the DC–T cell coculture experiment, a significantly decreased Th17 differentiation was observed upon betaine treatment. All of these data demonstrated that betaine inhibited Th17 differentiation indirectly by reducing IL-6 production by DCs. In brief, our findings demonstrated the pivotal roles of betaine in modulating MS pathogenesis and suggested that it may serve as a potential novel drug candidate for the treatment of MS.
IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection
Authors: Kuriakose Teneema , Zheng Min , Neale Geoffrey , Kanneganti Thirumala-Devi
Published: January 2018

Innate immune sensing of influenza A virus (IAV) induces activation of various immune effector mechanisms, including the nucleotide and oligomerization domain, leucine-rich repeat–containing protein family, pyrin domain containing 3 (NLRP3) inflammasome and programmed cell death pathways. Although type I IFNs are identified as key mediators of inflammatory and cell death responses during IAV infection, the involvement of various IFN-regulated effectors in facilitating these responses are less studied. In this study, we demonstrate the role of IFN regulatory factor (IRF)1 in promoting NLRP3 inflammasome activation and cell death during IAV infection. Both inflammasome-dependent responses and induction of apoptosis and necroptosis are reduced in cells lacking IRF1 infected with IAV. The observed reduction in inflammasome activation and cell death in IRF1-deficient cells during IAV infection correlates with reduced levels of Z-DNA binding protein 1 (ZBP1), a key molecule mediating IAV-induced inflammatory and cell death responses. We further demonstrate IRF1 as a transcriptional regulator of ZBP1. Overall, our study identified IRF1 as an upstream regulator of NLRP3 inflammasome and cell death during IAV infection and further highlights the complex and multilayered regulation of key molecules controlling inflammatory response and cell fate decisions during infections.
Seroprevalence of Ebola virus infection in Bombali District, Sierra Leone
Authors: Mafopa Nadege Goumkwa , Russo Gianluca , Guetiya Wadoum Raoul Emeric , Iwerima Emmanuel , Batwala Vincent , Giovanetti Marta , Minutolo Antonella , Turay Patrick , Turay Thomas B. , Kargbo Brima , Amicosante Massimo , Maurizio Mattei , Montesano Carla , Group Ebola Study
Published: January 2018

A serosurvey of anti-Ebola Zaire virus nucleoprotein IgG prevalence was carried out among Ebola virus disease survivors and their Community Contacts in Bombali District, Sierra Leone. Our data suggest that the specie of Ebola virus (Zaire) responsible of the 2013-2016 epidemic in West Africa may cause mild or asymptomatic infection in a proportion of cases, possibly due to an efficient immune response.
Effets de la contamination expérimentale in vitro des embryons de souris et de brebis par Campylobacter fetus
Authors: Guérin Bernard , Builly J. P. , Humblot P. , Nibart M. , Thibier Michel
Published: January 2018

Effects of Campylobacter fetus in vitro experimental infection of mice and ewes embryos.

A total of 350 ZP-I, days 3-5 mice embryos were collected and subdivided as follows : 184 were exposed to C. fetus ss fetus compared to 46 controls (non contaminated) and 182 exposed to C. fetus ss venerealis compared to 48 controls.

In addition, 164 ZP-I, day 6 sheep embryos were collected and contaminated with C. fetus ss fetus compared to 51 control embryos.

The mice embryos were submitted for 48 hours at 37°C to a range of 0.01-100 IDso and the sheep embryos to a range of 0.1-100 ID50. After 48 hours, the non-degenerated embryos were washed, homogeneized and then cultured simultaneously to the washing fluids for search of Campylobacter fetus.

After 48 hours, a dose-effect on the survival rate of the embryos (p < 0.001) and a duration-effect (p < 0.01) of the contamination are shown both for mice and sheep embryos for the two species of Campylobacter fetus.

No Campylobacter fetus either in mice or sheep were isolated in the last washing mediums nor in the homogeneized embryos.
Épidémiologie de la leishmaniose cutanée dans le sud du Maroc et dans le sud-est de l’Arabie
Authors: Petter Francis
Published: January 2018

Epidemiology of cutaneous leishmaniosis in southern morocco and in eastern Arabia.

In southern Morocco as in eastern Arabia, new socio-economic conditions combinated with exceptional environmental factors are responsible of the ecological desequilibrium which determines an epidemy of leishmaniosis.

In southern Morocco most active people have left their traditional cultiva¬ tion areas when rodents are no longer managed and give rise to pullulations.

In Arabia the quick extension of a town in a Psammomys community leads to the same results.
Les palmipèdes. Ethnozoologie et ethnozootechnie
Authors: Rousseau Michel
Published: January 2018

Les Palmipèdes sont étudiés ici à travers un numéro spécial (39) que leur a consacré la revue Ethnozootechnie : dans l’élevage donc, mais aussi à la chasse, à travers l’histoire, les pays (Gascogne, Taïwan, Argentine) et les peuples (Tsiganes...). L’Auteur les avait situés «dans le symbolisme et les croyances, les lettres et les arts». Il complète cette synthèse par une exposition.
Croissance de jeunes rats exposés au champ électrique sur plusieurs générations
Authors: Le Bars Henri , Pupin Françoise , Cabanes J.
Published: January 2018

L’étude de la croissance de jeunes rats Sprague-Dawley exposés à un champ électrique de 50 kv/m, 18 h/ jour a été suivie au cours de sept générations successives. De légers retards de croissance pondérale ont été observés après le sevrage pour certaines générations.
Désinfection de cuves et fosses à lisier contaminées par le virus de la fièvre aphteuse
Authors: Gourreau Jean-Marie , Petit T.
Published: January 2018

Le risque de dissémination du virus aphteux par les lisiers contaminés a conduit les auteurs à étudier un procédé de destruction de ce germe dans les effluents de porcherie par acidification à l’aide d’acide nitrique ou par alcalinisation à l’aide de chaux vive.
Maladies respiratoires chroniques et tabagisme
Authors: Voisin C. , Degreef J. M.
Published: January 2018

Chronic respiratory diseases related to tabagism

Chronic obstructive lung diseases (COPD) — including chronic bronchitis and emphysema — are an important and increasing public health problem, in which cigarette smoking has been identified as the main responsible factor. Clinical and epidemiological investigations have indicated a strong dose-response relation between COPD and the number of cigarettes smoked per day, the earliness of smoking initiation and the depth of smoke inhalation. In addition, passive inhalation of tobacco smoke may have adverse effects on the respiratory function in children and adolescents, particularly in asthmatics.

Experimental studies have demonstrated that tobacco smoke induced inflammatory changes in bronchial mucosa, with ciliary dysfunction and excessive mucus secretion, favouring bacterial colonization and bronchial infection. In the lower respiratory tract of smokers, alveolar macrophages demonstrate many metabolic and functional alterations, with increase in superoxide anion production, neutrophil chemotactic activity and protease secretion, leading to an imbalance between proteases, especially elastase, and alpha 1 protease inhibitor. These changes in alveolar macrophage activities result in alveolar wall damage and enlargement of the distal air spaces. Further research is needed to identify the effects of tobacco smoke components on the respiratory tract, and to evaluate preventive approaches.
Encéphalite à rouget (Erysipélothrix rhusiopathiae), chez le cheval
Authors: Vaissaire Josée , Plateau Éric , Gillet J. P. , Laroche Micheline , Mirial Ginette
Published: January 2018

Erysipelothrix rhusiopathiae encephalitis in a horse.

The authors report the case of Erysipelothrix rhusiopathiae encephalitis in a horse, this germ is unfrequently described in this specie. Erysipelothrix rhusiopathiae serotype 2 is involved in this case, most communly found in the others domestic and wild animals species. The animal has been found dead in meadow in the abounding area.
Epidermolyse bulleuse jonctionnelle léthale chez le cheval de trait en France
Authors: Gourreau Jean-Marie , Feillou C. , Morand M. , Courreau J.-F. , Duperé A.-M. , Alliot A.
Published: January 2018

Cinq cas d'épidermolyse bulleuse jonctionnelle léthale (Epitheliogenesis imperfecta) ont été diagnostiqués au début de l’année 1989 dans deux races de cheval de trait en France.

Les études anatomocliniques, ultra-structurales et génétiques montrent qu’il s’agit d'une affection héréditaire à déterminisme autosomal récessif analogue à l’épidermolyse bulleuse jonctionnelle léithale décrite par Herlitz chez l'homme car le clivage de la jonction dermo-épidermique se situe au-dessus de la basale, au sein de la Lamina lucida. Il s'agit des premiers cas de cette maladie décrits chez le cheval en France.
Le statut des animaux d’expérience. II. La mise en œuvre du décret du 19 octobre 1987
Authors: Seynave René Lucien , Wintergest Jacques
Published: January 2018

Les dispositions du décret du 19 octobre 1987 sont précisées et complétées par trois arrêtés interministériels du 19 avril 1988 et mises en œuvre dans la pratique administrative depuis août 1988.

A leur demande, d’une part les expérimentateurs utilisant des animaux vertébrés vivants sont autorisés au vu de leur compétence, d’autre part, les laboratoires sont agréés si leurs installations, leur fonctionnement, le nombre et la qualification de leurs personnels répondent aux exigences réglementaires.

Une personne autorisée ne peut pratiquer que dans un laboratoire agréé.

Les Vétérinaires Inspecteurs du Ministère de l’Agriculture et de la Forêt assurent les contrôles.

La Commission Nationale de l'Expérimentation Animale aide à la définition d’une politique de l’utilisation des animaux à des fins expérimentales.

L’ensemble de ces mesures prises pour protéger les animaux contre les mauvais traitements ou les utilisations abusives rejoignent les préoccupations d’amélioration de la qualité des expériences, développées notamment dans les Bonnes Pratiques de Laboratoires en Toxicologie.
L’encéphalite spongiforme bovine (E.S.B.) en Europe
Authors: Savey Marc , Parodi André-Laurent , Maillot Marie-Christine
Published: January 2018

The bovine spongiform encephalopathy in Europe.

The authors summarise the informations concerning B.S.E. in Great-Britain. They describe measures implemented by United Kingdom and other countries of E.E.C. to protect human and animal health. They propose a methodology to investigate clinical case of B.S.E. which could occurred in France.
Providing Patients with Implantable Cardiac Device Data through a Personal Health Record: A Qualitative Study
Authors: Daley Carly , Chen Elizabeth , Roebuck Amelia , Ghahari Romisa , Sami Areej , Skaggs Cayla , Carpenter Maria , Mirro Michael , Toscos Tammy
Published: January 2018

Background Patients at risk for sudden cardiac death or having suffered cardiac arrest may receive an implantable cardioverter defibrillator (ICD). This device provides monitoring and therapy for life-threatening heart rhythms. Remote monitoring of ICDs has decreased the time between abnormal heart rhythm events and clinic follow-up. Currently, the data transmitted from the device are reviewed and stored by the clinic, but patients do not have access to the data. While connecting patients directly with their ICD data has potential to enhance engagement in their care and improve health outcomes, patient attitudes and perceptions about receiving ICD data have not been explored.

Objective This research is the first demonstration of delivering ICD data to patients through a personal health record (PHR) using a novel technical framework. The objective of this study was to use a PHR interface as a technology probe to explore patients' experiences with directly receiving their ICD data from remote monitoring.

Methods We enrolled 21 patients with an ICD undergoing remote monitoring at a large outpatient cardiology clinic in Indiana, United States. Participants received their ICD data from remote monitoring through a PHR over 3 months. In-depth, semistructured interviews were conducted at 3 months and analyzed using thematic analysis.

Results Participants were 36 to 86 years old, mean age (SD) of 67 (14) years, predominately male (76%), and white (95%). Key themes were ICD questions and concerns, experiences with remote monitoring, PHR use, and feedback about the ICD data summary. The findings showed that overall, patients desired information that provides reassurance, is easy to understand, and is presented in a meaningful way.

Conclusion Sharing ICD data from remote monitoring requires adequate context and scaffolding to support patient understanding. Engaging patients with information that is useful and valuable to them through a PHR may require appropriate and individualized tailoring of information.
Skills Students Need in the Real World: Competencies Desired by Agricultural and Natural Resources Industry Leaders
Authors: Easterly III R. G. (Tre) , Warner Anna J. , Myers Brian E. , Lamm Alexa J. , Telg Ricky W.
Published: January 2018

The competencies addressed by undergraduate agricultural education programs should be assessed so programs are effective in supplying a well-prepared agricultural- and natural resources-oriented workforce, and so human capital is optimized. In this study, agricultural and natural resources leaders were surveyed to determine the workforce competencies they believed graduates of post-secondary agricultural education programs should have obtained. An Internetbased survey was distributed to graduates of an agricultural leadership development (ALT) group and a natural resources leadership development (NRLT) Group. The highest-rated workforce competency categories for the ALT group were being dependable (n = 103), critical thinking (n = 101), strategic planning (n = 98), and clear communication (n = 98); the highest-rated categories for the NRLT group were active listening (n = 73), clear communication (n = 72), and problem solving skills (n = 72). The personal and leadership skills subscales were not significantly different, but natural resources leaders ranked communication competencies as more important than agricultural leaders. Agricultural educators should evaluate the workforce competencies offered in their undergraduate programs and have deliberate conversations about meeting industry needs to better prepare a future workforce.
Global sensitivity and uncertainty analysis of an atmospheric chemistry transport model: the FRAME model (v. 9.15.0) as a case study
Authors: Aleksankina Ksenia , Heal Mathew R. , Dore Anthony J. , Van Oijen Marcel , Reis Stefan
Published: January 2018

Abstract. Atmospheric chemistry transport models (ACTMs) are widely used to underpin policy decisions associated with the impact of potential changes in emissions on future pollutant concentrations and deposition. It is therefore essential to have a quantitative understanding of the uncertainty in model output arising from uncertainties in the input pollutant emissions. ACTMs incorporate complex and non-linear descriptions of chemical and physical processes which means that interactions and non-linearities in input–output relationships may not be revealed through the local one-at-a-time sensitivity analysis typically used. The aim of this work is to demonstrate a global sensitivity and uncertainty analysis approach for an ACTM, using as an example the FRAME model, which is extensively employed in the UK to generate source-receptor matrices for the UK Integrated Assessment Model and to estimate critical load exceedances. An optimised Latin hypercube sampling design was used to construct model runs within ±40 % variation range for the UK emissions of SO2, NOx and NH3, from which regression coefficients for each input-output combination and each model grid (> 10,000 across the UK) were calculated. Surface concentrations of SO2, NOx and NH3 (and of deposition of S and N) were found to be predominantly sensitive to the emissions of the respective pollutant, while sensitivities of secondary species such as HNO3 and particulate SO42-, NO3- and NH4+ to pollutant emissions were more complex and geographically variable. The uncertainties in model output variables were propagated from the uncertainty ranges reported by the UK National Atmospheric Emissions Inventory for the emissions of SO2, NOx and NH3 (±4 %, ±10 % and ±20 % respectively). The uncertainties in the surface concentrations of NH3 and NOx and the depositions of NHx and NOy were dominated by the uncertainties in emissions of NH3, and NOx respectively, whilst concentrations of SO2 and deposition of SOy were affected by the uncertainties in both SO2 and NH3 emissions. Likewise, the relative uncertainties in the modelled surface concentrations of each of the secondary pollutant variables (NH4+, NO3-, SO42- and HNO3) were due to uncertainties in at least two input variables. In all cases the spatial distribution of relative uncertainty was found to be geographically heterogeneous. The global methods used here can be applied to conduct sensitivity and uncertainty analyses of other ACTMs.
Modelling hydrologic impacts of light absorbing aerosol deposition on snow at the catchment scale
Authors: Matt Felix N. , Burkhart John F. , Pietikäinen Joni-Pekka
Published: January 2018

Abstract. Light absorbing impurities in snow and ice (LAISI) originating from
atmospheric deposition enhance snowmelt by increasing the absorption of
shortwave radiation. The consequences are a shortening of the snow duration
due to increased snowmelt and, at the catchment scale, a temporal shift in
the discharge generation during the spring melt season. In this study, we present a newly developed snow algorithm for application in
hydrological models that allows for an additional class of input variable:
the deposition mass flux of various species of light absorbing aerosols. To
show the sensitivity of different model parameters, we first use the model as
a 1-D point model forced with representative synthetic data and investigate
the impact of parameters and variables specific to the algorithm determining
the effect of LAISI. We then demonstrate the significance of the radiative
forcing by simulating the effect of black carbon (BC) deposited on snow of a
remote southern Norwegian catchment over a 6-year period, from September 2006
to August 2012. Our simulations suggest a significant impact of BC in snow on
the hydrological cycle. Results show an average increase in discharge of 2.5,
9.9, and 21.4 %, depending on the applied model scenario, over a 2-month
period during the spring melt season compared to simulations where radiative
forcing from LAISI is not considered. The increase in discharge is followed
by a decrease in discharge due to a faster decrease in the catchment's
snow-covered fraction and a trend towards earlier melt in the scenarios where
radiative forcing from LAISI is applied. Using a reasonable estimate of
critical model parameters, the model simulates realistic BC mixing ratios in
surface snow with a strong annual cycle, showing increasing surface BC mixing
ratios during spring melt as a consequence of melt amplification. However, we
further identify large uncertainties in the representation of the surface BC
mixing ratio during snowmelt and the subsequent consequences for the snowpack
evolution.
Translating Expertise: The Librarian’s Role in Translational Research
Authors: Connor, AHIP Elizabeth
Published: January 2018

This volume includes case studies from librarians and other professional staff who are affiliated with CTSA consortium institutions and provides a wealth of first-hand information about supporting team science through collection development, instruction, data management, and collaborative partnerships.
El tratado musical de Pedro Martínez de Osma, un testimonio recuperado del siglo XV
Authors: Galán Gómez Santiago
Published: January 2018

Este artículo presenta un nuevo tratado musical español del siglo XV escrito por Pedro Martínez de Osma, catedrático de Teología en la Universidad de Salamanca. De esta obra se tenía noticia por referencias coetáneas debidas a su colega Ramos de Pareja, pero hasta ahora no se había identificado. Este texto, escrito en 1465 y conservado en la Biblioteca Nacional de Nápoles, permite obtener nueva información de un periodo muy poco explorado en cuanto al pensamiento musical en España, precisamente por la ausencia de fuentes documentales. Analizando su contenido se detalla el ambiente reformista y prehumanista que se vivía en esos años en el Estudio salmantino y se perfila la corriente de pensamiento que, pasando por Ramos y otros autores en torno al 1500, llevarán al florecimiento de los insignes autores del quinientos, en especial Francisco Salinas.
Potencial erosivo de doces azedos (sour candies) dissolvidos em água e saliva artificial
Authors: Farias Maria Mercês Aquino Gouveia , Soares Ana Keila , Bonvini Brenda , De Araújo Silvana Marchiori , Schmitt Beatriz Helena Eger
Published: January 2018

O consumo frequente de balas e doces ácidos está associado a etiologia da erosão dental. Objetivo: mensurar o potencial erosivo de doces azedos (sour candies) dissolvidos em água e saliva artificial. Métodos: os doces Sour Tubes Ácido Fini® sabores: maçã-verde, tutti-fruti, morango e melancia, foram selecionados e agrupados em 2 grupos. Doces dissolvidos em água destilada (G-1) e doces dissolvidos em saliva artificial (G-2). O pH foi mensurado utilizando um potenciômetro e eletrodo combinado de vidro previamente calibrado com soluções padrão pH 7,0 e pH 4,0, antes de cada leitura. A acidez titulável foi mensurada, adicionando-se alíquotas de 100 μL NaOH 1M, até alcançar o pH 5,5. Os resultados foram submetidos à Análise de Variância (ANOVA) e as comparações das médias realizadas pelo teste Tukey, em um nível de 5% de significância (p
Diagnóstico diferencial de tumores de glândulas salivares maiores
Authors: Pigozzi Lucas Bozzetti , Morawski Rafael , Burzlaff João Batista , Tonietto Leonardo , Silveira Vinícius Salim , Calcagnotto Tiago
Published: January 2018

As glândulas salivares podem apresentar diversas patologias. Dentre elas, as neoplasias de glândulas salivares são lesões incomuns e normalmente benignas, porém em casos menos frequentes, são lesões malignas. Quando essas lesões apresentam malignidade, uma conduta terapêutica específica deve ser empregada, tendo uma abordagem, muitas vezes, mais radical que a conduta cirúrgica utilizada em tumores benignos. Dentre as neoplasias malignas, os adenocarcinomas são lesões de difícil diagnóstico clínico e histopatológico. Por isso, o diagnóstico diferencial é fundamental na determinação da escolha de tratamento dessas neoplasias, uma vez que além da conduta terapêutica diferente, as lesões malignas podem gerar metástases em outras partes do corpo, tornando o prognóstico de sobrevida do paciente menos positivo. Dessa maneira, este trabalho tem como objetivo abordar e discutir, através do relato de caso, aspectos clínicos e imaginológicos capazes de estabelecer o diagnóstico diferencial das lesões tumorais de glândulas salivares maiores. O correto diagnóstico associado à uma terapêutica adequada e, principalmente, ao diagnóstico precoce do tipo de lesão leva a um aumento da sobrevida e a uma melhor qualidade de vida ao paciente acometido por uma neoplasia maligna de glândula salivar maior.
Determinantes que inciden en la calidad de rendimiento académico de los estudiantes de ingeniería
Authors: Navarro Hudiel Sergio Junior , Blandón Navarro Sandra Lorena
Published: January 2018

Los factores determinantes del rendimiento académico para las instituciones educativas  representan un proceso complejo. Muchos de los aspectos  abordados en el presente ensayo hacen referencia a la interacción multidimensional entre elementos  de carácter  personal, institucional, socio económico así como tecnológico. Esta revisión destaca la importancia del análisis y evaluación del rendimiento académico para los formados en la ingeniería  y la necesidad de evaluar los niveles de empleabilidad que permitan valorar el aporte de las instituciones de educación superior en su entorno, pudiendo así realizar políticas tanto a corto, mediano y largo plazo  que permitan aumentar las posibilidades  para el empleo de sus estudiantes. Las acciones estratégicas propuestas deberán de incluir el vínculo de las universidades con los distintos sectores que dinamizan las economías de modo que en conjunto pueden resolverse problemáticas a nivel  empresarial, local y nacional que se traduzca en elementos importantes del desarrollo local.
Conflictos y relaciones en los equipos de trabajo de las organizaciones
Authors: Gutierrez Taniuska
Published: January 2018

El artículo tiene como objetivo mostrar algunas reflexiones en torno a los conflictos  que se presentan dentro de los equipos de trabajo.  Haciendo una observación en las distintas actitudes y acciones de los integrantes de grupos de trabajo, surge la gran inquietud de saber por qué hay tanta fricción en las relaciones interpersonales; quizás sea parte de la competitividad nata del ser humano o simplemente se involucran otros factores aún no valorados ni reconocidos a la hora de comprender y contratar al talento humano, como lo son las habilidades sociales que posee cada quién para resolver conflictos, dar su opinión y saber defender la razón por encima de su ego
Estimación del Balance Fiscal Estructural en Nicaragua Para el Periodo 1994 - 2016
Authors: Morales Rivas Oliver David , Flores Mendez Leonel Antonio
Published: January 2018

El artículo presenta la estimación de un indicador de balance fiscal estructural para Nicaragua. Para ello, se utilizó la metodología general propuesta por FMI, para lograr este propósito estimaron dos modelos econométricos, el primero para determinar la elasticidad de los ingresos tributarios y el segundo para la elasticidad gasto corriente con respecto al Producto Interno Bruto Nacional Real y también se usó el Filtro Hodrick- Prescott para estimar el PIB Potencial, los datos se obtuvieron del Anuario Estadístico del Banco Central de Nicaragua. El balance fiscal estructural estimado empíricamente tiene el mismo comportamiento que la brecha entre producto efectivo y el potencial, además se infiere que el resultado de la política fiscal obedece a un componente estructural de la actividad económica.
Agua virtual y desarrollo sostenible
Authors: Ambrogi Román Rosario
Published: January 2018

El presente artículo trata un tema bastante novedoso, es la conceptualización e importancia económica  del análisis del Agua Virtual, para introducir en la discusión académica   la sostenibilidad del capital natural, y como sabemos El Agua es un recurso natural de vital importancia tanto como un insumo es los principales procesos productivos, así como también elemento esencial para mantener la vida, por tanto debe ser considerado uno de los principales componentes del capital natural de una nación, y debemos analizar su uso racional, su reposición y conservación para garantizar la sostenibilidad de la estructura económica.  Por tanto su contenido está enfocado en aspectos conceptuales para comprender a que nos referimos cuanto escuchamos sobre el Agua Virtual, cuál es la relación y diferencia entre este concepto y la huella hídrica?. Como podemos cuantificarla y porque es importante hacerlo.  Aquí se presente un pequeño ejercicio sobre la base lo que se requiere de agua para producir algunos rubros que ocupan un lugar considerable dentro de la estructura productiva, que nos permite sentarnos a reflexionar sobre que estamos haciendo para garantizar el uso de los recursos hoy y en el futuro.
Importancia de conservar la calidad y transparencia del record crediticio
Authors: Fonseca Zavala Arellys Belen , Jarquin Icabalceta Frania Valeska , Núñez Castillo Yarlen Alli
Published: January 2018

El presente estudio tiene como objetivo revelar información referente al record crediticio y la importancia de conservar la excelencia de este. Se llevó a cabo una encuesta tomando una muestra de 36 personas, las preguntas están relacionados al record crediticio.  Mediante los resultados obtenidos se concertó que la mayor proporción de los encuestados consideran importante conservar un excelente historial de crédito para obtener futuros beneficios financieros, en su mayoría préstamos y financiamiento de viviendas, sin embargo desconocen la incidencia del record crediticio en el ámbito laboral.  El record crediticio es un elemento fundamental en las finanzas de aquellas personas que manejan un papel de cliente dentro de las instituciones financieras. Su manejo y mejoramiento irá en dependencia de la administración de los ingresos y la cultura de pago, como también de una guía de información que se tenga con respecto al cumplimiento de sus obligaciones y las consecuencias que podría tener a nivel social, socioeconómico e incluso educativo.
Experiencia de la Dolarización en El Salvador
Authors: Nicaragua Solórzano Alexis Abraham
Published: January 2018

Durante la elaboración del siguiente escrito, se evidenciaron ciertos comportamientos y tendencias que captaron especialmente la atención, entre los cuales figuró el incremento en la brecha comercial (Déficit de las exportaciones netas), la poca rotación del dólar en la compra de bienes y servicios, y la estabilidad macroeconómica en ciertos sectores de la esfera económica; Además, de la alta dependencia del Salvador de las políticas implementadas en Estados Unidos. El análisis de los diversos sectores abarcados en este escrito provee al lector una idea clara sobre el verdadero impacto de una dolarización, en una economía en vías de desarrollo como lo es la  del Salvador
Análisis del desempeño laboral de los graduados universitarios desde su propia perspectiva. Estudios en Lengua y Literatura Hispánicas de la Facultad de Educación e Idiomas de la UNAN-Managua
Authors: Cruz-Díaz Rocío , Cuadra Baquedano Nora
Published: January 2018

En este artículo, la autoría presenta las evidencias investigadoras interesadas en la evaluación institucional obtenidas de una sección del estudio titulado: Desempeño y satisfacción laboral de los graduados de la carrera de Lengua y Literatura Hispánicas de la Facultad de Educación e Idiomas de la Universidad Nacional Autónoma de Nicaragua, Managua, entre el 2009-2013. El objeto del estudio, a nivel general, es abordar la valoración y análisis que manifiestan los graduados y empleadores sobre tres grandes factores: la satisfacción, el desempeño laboral y el perfil profesional de los graduados. En este estudio, por considerarlo uno de los ejes vertebrales de la investigación, se ofrecen los resultados referidos al desempeño laboral de la población en estudio. La muestra está conformada por 174 graduados a quienes se les aplicó un cuestionario diseñado en escala Likert, utilizando categorías excluyentes, nominales e ítems de escala, en los que se les pide valoren su satisfacción ante su formación y su puesto de trabajo, su desempeño laboral y las características esenciales de su perfil profesional. El instrumento fue autoadministrado y respondido tanto por vía correo electrónico, como de manera directa. De acuerdo con los resultados obtenidos en el análisis de datos estadísticos mediante el programa SPSS V 21, un porcentaje muy alto (90%) de los graduados encuestados se encuentra empleado en el área para la cual fueron formados (docencia en diferentes niveles de la educación), los graduados valoran muy positivo su desempeño laboral, no obstante, consideran que deben fortalecerse ciertas habilidades que les permitan desempeñar mejor su profesión.
Do Covenants of Bonds Outstanding Affect the Choice of Covenants of New Issues? Evidence from the U.S. Corporate Bonds
Authors: Wang Yuqian , Chiu Che-Wei , Wrolstad Mark
Published: January 2018

This paper investigates the relation between debt covenants of a firm’s bonds outstanding and covenants of its newly issued bonds. On the one hand, since covenants are priced and costly, newly issued bonds may not include covenants that have been used in bonds outstanding, suggesting a negative relation between covenants of bonds outstanding and those of new issues. On the other hand, since firms tend to use boilerplate language in debt indentures, similar covenants of bonds outstanding are likely to be used repeatedly in the contracts of new issues, indicating a positive relation. Based on the U.S. public corporate bonds data from 1990 to 2014, this paper provides empirical evidence that covenants of a firm’s new issues are positively related to covenants of its bonds outstanding, suggesting boilerplate language is widely used in corporate bond contracts. Results also show that use of boilerplate language is significantly related to issuers’ financial condition and economic cycle. Issuers with stable financial condition, as measured by commercial paper ratings, tend to use boilerplate language more frequently. And during the Dot-Com bubble period, boilerplate language is used more prevalently than during the financial crisis period.