bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of CD74 Occurrence in Oncogenic Fusion Proteins
Authors: Vargas Jasmine , Pantouris Georgios
Published: November 2023

CD74 is a type II cell surface receptor found to be highly expressed in several hematological and solid cancers, due to its ability to activate pathways associated with tumor cell survival and proliferation. Over the past 16 years, CD74 has emerged as a commonly detected fusion partner in multiple oncogenic fusion proteins. Studies have found CD74 fusion proteins in a range of cancers, including lung adenocarcinoma, inflammatory breast cancer, and pediatric acute lymphoblastic leukemia. To date, there are five known CD74 fusion proteins, CD74-ROS1, CD74-NTRK1, CD74-NRG1, CD74-NRG2α, and CD74-PDGFRB, with a total of 16 different variants, each with unique genetic signatures. Importantly, the occurrence of CD74 in the formation of fusion proteins has not been well explored despite the fact that ROS1 and NRG1 families utilize CD74 as the primary partner for the formation of oncogenic fusions. Fusion proteins known to be oncogenic drivers, including those of CD74, are typically detected and targeted after standard chemotherapeutic plans fail and the disease relapses. The analysis reported herein provides insights into the early intervention of CD74 fusions and highlights the need for improved routine assessment methods so that targeted therapies can be applied while they are most effective.
APOE ε4-Allele in Middle-Aged and Older Autistic Adults: Associations with Verbal Learning and Memory
Authors: Harker Samantha A. , Al-Hassan Lamees , Huentelman Matthew J. , Braden B. Blair , Lewis Candace R.
Published: November 2023

Autism spectrum disorder (ASD) is a neurodevelopmental disability and recent evidence suggests that autistic adults are more likely to develop Alzheimer’s disease (Alz) and other dementias compared to neurotypical (NT) adults. The ε4-allele of the Apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alz and negatively impacts cognition in middle-aged and older (MA+) adults. This study aimed to determine the impact of the APOE ε4-allele on verbal learning and memory in MA+ autistic adults (ages 40–71 years) compared to matched NT adults. Using the Auditory Verbal Learning Test (AVLT), we found that ε4 carriers performed worse on short-term memory and verbal learning across diagnosis groups, but there was no interaction with diagnosis. In exploratory analyses within sex and diagnosis groups, only autistic men carrying APOE ε4 showed worse verbal learning (p = 0.02), compared to autistic men who were not carriers. Finally, the APOE ε4-allele did not significantly affect long-term memory in this sample. These findings replicate previous work indicating that the APOE ε4-allele negatively impacts short-term memory and verbal learning in MA+ adults and presents new preliminary findings that MA+ autistic men may be vulnerable to the effects of APOE ε4 on verbal learning. Future work with a larger sample is needed to determine if autistic women may also be vulnerable.
Mice Lacking PLAP-1/Asporin Show Alteration of Periodontal Ligament Structures and Acceleration of Bone Loss in Periodontitis
Authors: Kinoshita Masaki , Yamada Satoru , Sasaki Junichi , Suzuki Shigeki , Kajikawa Tetsuhiro , Iwayama Tomoaki , Fujihara Chiharu , Imazato Satoshi , Murakami Shinya
Published: November 2023

Periodontal ligament-associated protein 1 (PLAP-1), also known as Asporin, is an extracellular matrix protein expressed in the periodontal ligament and plays a crucial role in periodontal tissue homeostasis. Our previous research demonstrated that PLAP-1 may inhibit TLR2/4-mediated inflammatory responses, thereby exerting a protective function against periodontitis. However, the precise roles of PLAP-1 in the periodontal ligament (PDL) and its relationship to periodontitis have not been fully explored. In this study, we employed PLAP-1 knockout mice to investigate its roles and contributions to PDL tissue and function in a ligature-induced periodontitis model. Mandibular bone samples were collected from 10-week-old male C57BL/6 (WT) and PLAP-1 knockout (KO) mice. These samples were analyzed through micro-computed tomography (μCT) scanning, hematoxylin and eosin (HE) staining, picrosirius red staining, and fluorescence immunostaining using antibodies targeting extracellular matrix proteins. Additionally, the structure of the PDL collagen fibrils was examined using transmission electron microscopy (TEM). We also conducted tooth extraction and ligature-induced periodontitis models using both wild-type and PLAP-1 KO mice. PLAP-1 KO mice did not exhibit any changes in alveolar bone resorption up to the age of 10 weeks, but they did display an enlarged PDL space, as confirmed by μCT and histological analyses. Fluorescence immunostaining revealed increased expression of extracellular matrix proteins, including Col3, BGN, and DCN, in the PDL tissues of PLAP-1 KO mice. TEM analysis demonstrated an increase in collagen diameter within the PDL of PLAP-1 KO mice. In line with these findings, the maximum stress required for tooth extraction was significantly lower in PLAP-1 KO mice in the tooth extraction model compared to WT mice (13.89 N ± 1.34 and 16.51 N ± 1.31, respectively). In the ligature-induced periodontitis model, PLAP-1 knockout resulted in highly severe alveolar bone resorption, with a higher number of collagen fiber bundle tears and significantly more osteoclasts in the periodontium. Our results demonstrate that mice lacking PLAP-1/Asporin show alteration of periodontal ligament structures and acceleration of bone loss in periodontitis. This underscores the significant role of PLAP-1 in maintaining collagen fibrils in the PDL and suggests the potential of PLAP-1 as a therapeutic target for periodontal diseases.
Structural Health Monitoring-Based Bridge Lifecycle Extension: Survival Analysis and Monte Carlo-Based Quantification of Value of Information
Authors: Valkonen Antti , Glisic Branko
Published: November 2023

A key goal of structural health monitoring (SHM) systems applied to infrastructure is to improve asset management. SHM systems yield benefits by providing information that allows improved asset management decisions. Often, improvement is measured in monetary terms, whereby lower expenses are sought. The value of information (VoI) is often evaluated through the quantification of the incremental benefit, resulting from the information provided by the SHM system. The VoI can be considered as having two components: value derived from the improved operation of the infrastructure and value derived from increased useful life. This work focuses on the latter source of value in the context of concrete decks in US highway bridges. To estimate the lifecycle extension potential and the connected VoI, we need to simulate bridge deck condition degradation over time to support a discounted cash flow analysis of bridge replacement cost. We accomplish this by utilizing a neural network-based survival analysis combined with Monte Carlo simulation. We present a case study using the developed methods. We have chosen to study the southbound portion of the bridge on the US Highway 202, located in Wayne, NJ. The selected bridge is a representative concrete highway overpass, the type of which there are large numbers in the US. The case study demonstrates the applicability of the methods developed for the general evaluation of the VoI obtained via SHM. The results are encouraging for the widespread use of SHM for lifecycle extension purposes; the potential value in such applications is large.
Immune Mediators Profiles in the Aqueous Humor of Patients with Simple Diabetic Retinopathy
Authors: Yamakawa Naoyuki , Komatsu Hiroyuki , Usui Yoshihiko , Tsubota Kinya , Wakabayashi Yoshihiro , Goto Hiroshi
Published: November 2023

Various immune mediators identified to date are associated with the development of advanced forms of diabetic retinopathy (DR), such as proliferative DR and diabetic macular edema, although the exact pathophysiological mechanisms of early stages of DR such as simple DR remain unclear. We determined the immune mediator profile in the aqueous humor of eyes with simple DR. Fifteen eyes of fifteen patients with simple DR were studied. Twenty-two eyes of twenty-two patients with cataracts and no DR served as controls. Undiluted aqueous humor samples were collected, and a cytometric bead array was used to determine the aqueous humor concentrations of 32 immune mediators comprising 13 interleukins (IL), interferon-γ, interferon-γ-inducible protein-10 (IP-10), monocyte chemoattractant protein-1, macrophage inflammatory protein (MIP)-1α, MIP-1β, regulated on activation, normal T cell expressed and secreted (RANTES), monokine induced by interferon-γ, basic fibroblast growth factor (bFGF), Fas ligand, granzyme A, granzyme B, interferon-inducible T-cell alpha chemoattractant (ITAC), fractalkine, granulocyte macrophage colony-stimulating factor, granulocyte colony-stimulating factor (G-CSF), vascular endothelial growth factor (VEGF), angiogenin, tumor necrosis factor-α, and CD40 ligand. Among the 32 immune mediators, 10 immune mediators, including bFGF, CD40 ligand, fractalkine, G-CSF, IL-6, IL-8, MIP-α, MIP-1β, and VEGF, showed significantly higher aqueous humor concentrations and the Fas ligand had significantly lower concentration (p < 0.05) in eyes with simple DR compared with control eyes. Of these 10 cytokines with significant concentration alteration, protein–protein interaction analysis revealed that 8 established an intricate interaction network. Various immune mediators may contribute to the pathogenesis of simple DR. Attention should be given to the concentrations of immune mediators in ocular fluids even in simple DR. Large-scale studies are warranted to assess whether altered aqueous humor concentrations of these 10 immune mediators are associated with an increased risk of progression to advanced stages of DR.
Reducing the Risk of Birth Defects Associated with Maternal Influenza: Insights from a Hungarian Case—Control Study
Authors: Mátrai Ákos , Teutsch Brigitta , Pethő Boglárka , Kaposi András D. , Hegyi Péter , Ács Nándor
Published: November 2023

Influenza viruses can cause several complications during pregnancy. Therefore, we aimed to investigate the effects of influenza on the development of congenital abnormalities (CAs) by analyzing the database of the Hungarian Case–Control Surveillance of Congenital Abnormalities (HCCSCA). In our multicenter, case–control, population-based study, we processed clinician-reported outcomes and diagnoses collected in the HCCSCA. The case group included newborns with different non-chromosomal birth defects, while the controls were newborns without CAs. Maternal influenza, as a risk factor for CAs, was analyzed by using a logistic regression model and odds ratios with 95% confidence intervals (CIs). Our results showed that maternal influenza in the first trimester was associated with increased odds of developing non-chromosomal CAs (OR: 1.41, CI: 1.28–1.55). There were increased odds of neural tube defects (OR: 2.22, CI: 1.78–2.76), orofacial clefts (OR: 2.28, CI: 1.87–2.78), and congenital heart defects (OR: 1.28, CI: 1.10–1.49) after influenza infection. In all cases, we found a protective effect of folic acid supplementation in the first trimester. In summary, the odds of non-chromosomal birth defects are higher after maternal influenza in the first trimester, and folic acid or pregnancy vitamin supplementation and antipyretic therapy may reduce the effect of maternal influenza during the first trimester.
Spatiotemporal Distribution and Evolution Characteristics of Water Traffic Accidents in Asia since the 21st Century
Authors: Peng Zhenxian , Jiang Zhonglian , Chu Xiao , Ying Jianglong
Published: November 2023

As an important mode of transportation for the global trade, waterborne transportation has become a priority option for import and export trade due to its large load capacity and relatively low cost. Meanwhile, shipping safety has been highly valued. By collecting technological water traffic accident data from the EM-DAT database, the spatiotemporal distribution and evolution characteristics were investigated in Asia since 2000. The methods of gravity center and standard deviation ellipse analysis were utilized to determine the spatial and data-related characteristics of water traffic accidents. Temporally, the results indicated that accidents occurred most frequently during the seasons of autumn and winter, leading to a significant number of casualties. Spatially, both South-eastern Asia and Southern Asia emerged as regions with a high frequency of water traffic accidents, particularly along the borders of Singapore, Malaysia, Indonesia, and the Bay of Bengal region. In addition, the Daniel trend test and R/S analysis were conducted to demonstrate the evolution trend of accidents across various regions and seasons. The present study provides guidance for improving marine shipping safety, emergency resource management, and relevant policy formulation.
Living on the Coast in Harmony with Natural Processes
Authors: Carmo José Simão Antunes Do
Published: November 2023

The coastal zone is a fascinating place that comprises the interface between sea and land. This interface, which is both very dynamic and sensitive, has been affected by strong urban and industrial pressures, and an increase in both traffic and recreational uses, leading to the deterioration of natural habitats and the growing instability of residential areas. Added to this disruption is ongoing climate change, which will lead to rising sea levels and increased wave action. Another problem we are increasingly concerned about is ocean pollution, which has been one of the main causes of threats to deep-water coral reef areas. The main sources of pollution include oil spills and offshore oil drilling. The effects of pollution caused by oil spills can not only seriously affect the global environmental balance of our planet but can also, on a different scale, seriously affect the economy of countries whose main resources depend heavily on the sea. Wave energy has the potential to alleviate the world's dependence on depleting fossil energy resources. With regard to coastal protection, the development of ecological solutions to preserve ecosystems and address coastal processes as an alternative to traditional coastal protection structures (seawalls, groins and breakwaters) is becoming increasingly important. These structures, generally referred to as passive measures, are usually built to alter the effects of sea waves, currents and the movement of sand along the coastline, with the aim of protecting beaches, ports and harbors. The concerns outlined are critically addressed throughout this review article. All of them are highly relevant today and, as demonstrated throughout this article, are expected to grow even more and with much more pronounced consequences starting from the middle of the current century.
Enhancing Equation Solving: Extending the Applicability of Steffensen-Type Methods
Authors: Behl Ramandeep , Argyros Ioannis K. , Alansari Monairah
Published: November 2023

Local convergence analysis is mostly carried out using the Taylor series expansion approach, which requires the utilization of high-order derivatives, not iterative methods. There are other limitations to this approach, such as the following: the analysis is limited to finite-dimensional Euclidean spaces; no a priori computable error bounds on the distance or uniqueness of the solution results are provided. The local convergence analysis in this paper positively addresses these concerns in the more general setting of a Banach space. The convergence conditions involve only the operators in the methods. The more important semi-local convergence analysis not studied before is developed by using majorizing sequences. Both types of convergence analyses are based on the concept of generalized continuity. Although we study a certain class of methods, the same approach applies to extend the applicability of other schemes along the same lines.
Bifurcating Limit Cycles with a Perturbation of Systems Composed of Piecewise Smooth Differential Equations Consisting of Four Regions
Authors: Zhang Erli , Yang Jihua , Shateyi Stanford
Published: November 2023

Systems composed of piecewise smooth differential (PSD) mappings have quantitatively been searched for answers to a substantial issue of limit cycle (LC) bifurcations. In this paper, LC numbers (LCNs) of a PSD system (PSDS) consisting of four regions are dealt with. A Melnikov mapping whose order is one is implicitly obtained by finding its originators when the system is perturbed under any nth degree of real polynomials. Then, the approach employing the Picard–Fuchs mapping is utilized to attain a higher boundary of bifurcation LCNs of systems composed of PSD functions with a global center. The method we used could be implemented to examine the problems related to the LC of other PSDS.
Organic LEDs Based on Bis(8-hydroxyquinoline) Zinc Derivatives with a Styryl Group
Authors: Sypniewska Malgorzata , Pokladko-Kowar Monika , Gondek Ewa , Apostoluk Aleksandra , Kamedulski Piotr , Smokal Vitaliy , Song Peng , Liu Junyan , Szczesny Robert , Derkowska-Zielinska Beata
Published: November 2023

For the first time, organic light-emitting diodes (OLEDs) based on bis(8-hydroxyquinoline) zinc with a styryl group (ZnStq) dispersed in poly(N-vinylcarbazole) matrix (ZnStq_R:PVK, where R = H, Cl, OCH3) were fabricated. The ZnStq_R:PVK films made via the spin-coating method were used as the active layer in these devices. The produced OLEDs showed strong electroluminescence with yellow emissions at 590, 587 and 578 nm for the ZnStq_H:PVK, ZnStq_Cl:PVK and ZnStq_OCH3:PVK, respectively. For all the studied thin films, the main photoluminescence emission bands were observed between 565 and 571 nm. The OLED with the ZnStq_OCH3:PVK layer with a narrow electroluminescence spectrum was found to have sufficient color purity to produce ultra-high-resolution displays with reduced power consumption (full width at half maximum of 59 nm, maximum brightness of 2244 cd/m2 and maximum current efficiency of 1.24 cd/A, with a turn-on voltage of 6.94 V and a threshold voltage of 7.35 V). To characterize the photophysical properties of the active layer, the ZnStq_R:PVK layers samples were additionally deposited on glass and silicon substrates. We found that the obtained results predestine ZnStq_R:PVK layers for use in the lighting industry in the future.
New Optimization Framework for Improvement Sustainability of Wastewater Treatment Plants
Authors: Li Hang , Pang Fei , Xu Di , Dong Lichun
Published: November 2023

Enhancing the sustainability of wastewater treatment plants (WWTPs) is crucial due to their manifold benefits, which encompass environmental preservation, cost reduction, and resource and energy conservation. The achievement of these advantages relies on the careful choice and implementation of retrofit technologies to upgrade WWTPs. However, this decision-making process is intricate, given the trade-offs between the objectives and the inherent decision uncertainties. To address these complexities, this work presents an innovative weighted multi-objective optimization (MOO) framework tailored for WWTP enhancement amid uncertain conditions. This framework comprises two phases. The first phase involves basic definition and information collection through a case-specific assessment, while the second phase includes model formulation and solver optimization, which serves as a generic tool for the weighted MOO problem. In the model formulation, a combined weighting approach that integrates expert opinions and statistical insights is introduced to assign significance to each objective. The solver optimization employs a projection-based algorithm to identify the optimal technology configuration that achieves a satisfactory and balanced improvement across multiple sustainable objectives. By applying this framework to a case plant for retrofit technology selection, the comprehensive sustainability performance, the targeting of discharged pollution, the operational cost, and the GHG emissions improved by 46.7% to 68.3%.
Degassing Dissolved Oxygen through Bubbling: The Contribution and Control of Vapor Bubbles
Authors: Jun Yong-Du
Published: November 2023

An innovative yet sustainable approach for industrial deaeration is proposed, with demonstrated results and analyses, to contribute to finding solutions to improve energy efficiency in this field. Vacuum bubbling deaeration, sharing the same working principles of solubility control and the mass diffusion through vapor (or steam) with conventional thermal deaeration processes, works, however, at lower vacuum pressures. It neither resorts to heating nor requires any third-party materials such as membranes or gases, achieving orders of magnitude of reduction in the expected energy consumption in a simple and concrete way. In this study, the mechanisms of vapor bubble generation and retention were discussed by employing a vacuum bubbling model based on the experimental apparatus at Kongju National University, which uses a venturi-nozzle bubbler. The four parameters influencing vapor bubble generation and retention were identified as vessel pressure p1, nozzle depth Δh, nozzle performance p4−p3, and water temperature Tw. A series of deaeration experiments using the present approach for a tap water sample of 360~400 L were conducted under four different conditions to investigate the effects of the water temperature, vessel pressure, and bubbler nozzle depth. Final dissolved oxygen (DO) concentrations close to zero could be achieved with a vessel pressure of p1=1 kPa, with different bubbling times to reach a zero mg/L reading of DO concentration (case 2 and 3), which demonstrates the vital roles of the vapor bubble generation condition of (psat−p3)  and retention condition of (p4−psat) in achieving the lowest DO concentration. Analysis of the test results, based on the discrete-bubble model with the measured DO concentrations and degassing rates, showed promising results in reproducing the experimental data. Though the potential of vacuum bubbling deaeration is demonstrated, for the first time, to its full extent, further research efforts are encouraged in many areas, including more case-specific validation test cases with optimum operating conditions along with the study of more detailed modeling for performance prediction, including energy analysis.
Rapid Colloidal Gold Immunoassay for Pharmacokinetic Evaluation of Vancomycin in the Cerebrospinal Fluid and Plasma of Beagle Dogs
Authors: Guo Yechang , Wang Shaofeng , Li Peiyue , Zhang Pan , Wang Wei
Published: November 2023

Vancomycin (VAN), a glycopeptide antibiotic, is the preferred therapeutic agent for treating Gram-positive bacteria. Rapid and precise quantification of VAN levels in cerebrospinal fluid (CSF) and plasma is crucial for optimized drug administration, particularly among elderly patients. Herein, we introduce a novel clinical test strip utilizing colloidal gold competitive immunoassay technology for the expedient detection of VAN. This test strip enables the detection of VAN concentrations in clinical samples such as plasma within 10 min and has a limit of detection of 10.3 ng/mL, with an inhibitory concentration 50% (IC50) value of 44.5 ng/mL. Furthermore, we used the test strip for pharmacokinetic analysis of VAN in the CSF and plasma of beagle dogs. Our results provide valuable insights into the fluctuations of the drug concentration in the CSF and plasma over a 24 h period after a single intravenous dose of 12 mg/kg. The test strip results were compared with the results obtained via liquid chromatography–mass spectrometry methods, and the measured VAN concentrations in the CSF and plasma via both of the methods showed excellent agreement.
A Unified Efficient Deep Learning Architecture for Rapid Safety Objects Classification Using Normalized Quantization-Aware Learning
Authors: Stephen Okeke , Nguyen Minh
Published: November 2023

The efficient recognition and classification of personal protective equipment are essential for ensuring the safety of personnel in complex industrial settings. Using the existing methods, manually performing macro-level classification and identification of personnel in intricate spheres is tedious, time-consuming, and inefficient. The availability of several artificial intelligence models in recent times presents a new paradigm shift in object classification and tracking in complex settings. In this study, several compact and efficient deep learning model architectures are explored, and a new efficient model is constructed by fusing the learning capabilities of the individual, efficient models for better object feature learning and optimal inferencing. The proposed model ensures rapid identification of personnel in complex working environments for appropriate safety measures. The new model construct follows the contributory learning theory whereby each fussed model brings its learned features that are then combined to obtain a more accurate and rapid model using normalized quantization-aware learning. The major contribution of the work is the introduction of a normalized quantization-aware learning strategy to fuse the features learned by each of the contributing models. During the investigation, a separable convolutional driven model was constructed as a base model, and then the various efficient architectures were combined for the rapid identification and classification of the various hardhat classes used in complex industrial settings. A remarkable rapid classification and accuracy were recorded with the new resultant model.
A Subunit Vaccine Based on the VP2 Protein of Porcine Parvovirus 1 Induces a Strong Protective Effect in Pregnant Gilts
Authors: Ling Zhanye , Zhang Huawei , Chen Yingjin , Sun Leqiang , Zhao Junlong
Published: November 2023

Porcine parvovirus 1 (PPV1) is one of the most prevalent pathogens that can cause reproductive disorder in sows. The VP2 protein of PPV1 is the most important immunogenic protein that induces neutralizing antibodies and protective immunity. Thus, VP2 is considered an ideal target antigen for the development of a genetically engineered PPV1 vaccine. In this study, the baculovirus transfer vector carrying the HR5-P10-VP2 expression cassette was successfully constructed with the aim of increasing the expression levels of the VP2 protein. The VP2 protein was confirmed using SDS‒PAGE and Western blot analyses. Electronic microscope analysis showed that the recombinant VP2 proteins were capable of self-assembling into VLPs with a diameter of approximately 25 nm. The immunogenicity of the VP2 subunit vaccine was evaluated in pigs. The results showed that VP2 protein emulsified with ISA 201VG adjuvant induced higher levels of HI antibodies and neutralizing antibodies than VP2 protein emulsified with IMS 1313VG adjuvant. Furthermore, the gilts immunized with the ISA 201VG 20 μg subunit vaccine acquired complete protection against PPV1 HN2019 infection. In contrast, the commercial inactivated vaccine provided incomplete protection in gilts. Therefore, the VP2 subunit vaccine is a promising genetically engineered vaccine for the prevention and control of PPV1.
Öğretmenlerin Okullarına Yönelik Örgütsel Sinerji Algıları İle Liderlik Düzeyleri Arasındaki İlişkilerin İncelenmesi
Authors: AKER Coşku , B.BOSTANCI Aynur
Published: November 2023

Bu araştırma öğretmenlerin, okullarda örgütsel sinerjiye yönelik algıları ile liderlik düzeyleri arasındaki ilişkiyi belirlemek amacıyla gerçekleştirilmiştir. İlişkisel tarama modelindedir.. Araştırma evreni “2021-2022 eğitim öğretim yılında Uşak ilinde okullrda görev yapan 2798 öğretmen, örneklemini ise kolay ulaşılabilir örnekleme yoluyla ulaşılabilen 310 öğretmen oluşturmaktadır. Araştırmada veriler “Örgütsel Sinerji Ölçeği” ve “Öğretmen Liderliği Ölçeği” ile toplanmıştır. Araştırmadan elde edilen sonuçlara göre Öğretmenlerin okul içindeki örgütsel sinerji düzeyine ilişkin algıları yüksektir .- Öğretmenlerin örgütsel sinerjiye yönelik algıları okul düzeyine göre farklılaşmakta ve lise öğretmenlerinin örgütsel sinerjiye yönelik algılarının ilkokul ve ortaokul düzeyinde görev yapan öğretmenlere göre daha düşüktür. Yine ön lisans ve lisans eğitimine sahip öğretmenlerinin örgütsel sinerjiye yönelik algıları, yüksek lisans eğitimi almış öğretmenlere göre daha yüksektir. Öğretmenlerin okul içindeki örgütsel sinerjiye yönelik algıları diğer değişkenleri açısından ise farklılaşmamaktadır. Yine araştırmaya göre öğretmenlerin okuldaki liderlik rolü algılarının yüksektir. Öğretmenlerin liderlik rolüne yönelik algıları arasında cinsiyet, kıdem yılı, mezuniyet durumu görev yaptıkları okuldaki öğretmen sayısı ve aynı okulda yaklaşık çalışma süresi, değişkenlerine göre farklılaşmamaktadır. Okul düzeyine göre ise, Lise öğretmenlerinin liderlik rolüne yönelik algılarının ilkokul düzeyinde görev yapan öğretmenlere göre daha düşüktür. Araştırmada öğretmenlerin okul içerisindeki örgütsel sinerji algıları ile liderlik düzeyleri arasında anlamlı, pozitif yönde ve yüksek düzeyde ilişkiler bulunmakta ve okul içindeki örgütsel sinerji algıları liderlik düzeylerini anlamlı bir şekilde yordamaktadır. Okullardaki sinerji düzeyinin artması için öğretmenlerin takım çalışmasına teşvik edilmesi, orrtak etkileşimleri için etkinlikler düzenlenması önerilebilir.
GAMBARAN KEPATUHAN KONTROL PASIEN PASKA STROKE BERDASARKAN FAKTOR DEMOGRAFI
Authors: Andriani Sofi Novia , Hamzah Ali , Erlina Lina , Rumahorbo Hotma
Published: November 2023

This research was motivated by the high incidence and mortality of stroke patients in Indonesia every year. Strokes can also cause disability and even death and often occur repeatedly, so it is necessary to control risk factors that can prevent the occurrence of these attacks, among others by exercising routine control. Routine control needs to be followed by adherence from the patient so that the effectiveness of treatment and complications that may arise can be monitored and controlled. This study aims to determine the compliance of post-stroke control patients based on demographic factors in Dr. Salamunun Hospital. The research method used is descriptive method, with a total sample of 191 people obtained through total sampling techniques. The data obtained came from secondary data, namely from the patient's medical record report. The results showed that demographic factors had a contribution to patient compliance, which was based on the age factor of almost half (33.5%) patients aged> 65 years and more than half of the respondents were male patients (68.9%) obedient do control post stroke. Meanwhile, according to the level of education, almost half (37.8%) of the graduates who were educated were compliant to control, and almost half (44.4%) of those who worked as compliant entrepreneurs exercised control after stroke and according to the status of patient visits that adhered to control, which was partly besaar (86.7%) old patients. Thus it can be concluded that only a small proportion (23.6%) of stroke patients who adhere to routine control after they have had a stroke. For this reason it is advisable for nurses to always remind the control schedule of both the patient and the patient's family after stroke about 2-3 days before the control schedule via social media.
Prospective analysis of the impact of Chronic Kidney Disease on patients and caregivers
Authors: Pereira Beatriz dos Santos , Kirchmaier Filomena Maria , Fernandes Neimar da Silva , Suassuna Lucas Fernandes , Fernandes Natalia Maria da Silva
Published: November 2023

Introduction. Chronic kidney disease (CKD) has a high incidence, prevalence and morbidity and mortality among the world population, negatively impacting the biopsychosocial aspects of patients and family caregivers. Objective. To evaluate the association between the mental health of caregivers and CKD patients on dialysis. Method. A prospective cohort study, the sample included patients with CKD on dialysis at the University Hospital of the Federal University of Juiz de Fora (UFJF) and their family caregivers from 2015 to 2019. The instruments used for data collection were a sociodemographic questionnaire, the Perceived Social Support Scale (EPSS), the Hospital Anxiety and Depression Scale (HADS), the Lipp Stress Symptom Inventory (LISS), the SF-36 Quality of Life Questionnaire (SF-36), the Fatigue Pictogram. Results. Most patients were on haemodialysis for more than 4 years and were female, middle-aged, and black. Most caregivers were female, middle-aged and white. The participants in both groups predominantly married people with low levels of education. The general levels of mental health and quality of life (QoL) between patients and caregivers were similar.  Conclusion. The mental health of patients and their family caregivers was similarly and negatively affected by CKD; therefore, treatment and interdisciplinary mental health care measures are urgent for this population.
The Role of Classification of Endoscopic Sinus Surgery in Surgical Planning
Authors: Kishore G. Dr. Nanda , Tripuraneni Dr. Satish Chandra , K. K. Dr. Sravanthi , G Dr. Sameera
Published: November 2023

Endoscopic sinus surgery being an approach, there is no proper classification system to address the extent of surgery required for Sinonasal pathologies. The current study attempts to propose and evaluate the role and efficacy of a classification system for endoscopic sinus surgery in addressing various Sinonasal and skull base pathologies.
Materials and methods: It's a prospective study that included 50 patients. We classified ESS into six types based on the extent of surgery. After thorough evaluation, depending on the extent of the disease, all 50 patients were planned and treated according to the classification. Patients were followed for one year.
Programa COMFOR basado en enfoque por competencias para la práctica pedagógica en instituciones educativas públicas
Authors: Donato-Palacios Marleny , Calle-Díaz Juan Javier , Terrones-Marreros Mario Andrés , Duran-Llaro Kony Luby
Published: November 2023

La investigación tuvo por objetivo analizar la práctica pedagógica en relación a la calidad de aprendizajes de una institución educativa pública, provincia Virú. La población estuvo conformada por cuarenta docentes de dicha institución. Para la recolección de datos se utilizó la técnica de entrevista, como instrumento el cuestionario, validado por juicio de expertos. Los resultados, presentan una Confiabilidad Interna Significativa (alfa de Cronbach = 0.926 > 0.90), con una prueba piloto de 22 docentes; obteniéndose al aplicar el pre test que el 98% de docentes se encontraban en un nivel elemental, ejerciendo una práctica pedagógica rutinaria, practicista, poco reflexiva, con dificultad en el manejo pedagógico, escasamente auténtica y difícilmente ayudará a resolver problemas. Asimismo, el pos test, programa COMFOR, el 88% de docentes lograron ubicarse en un nivel competente, utilizando los conocimientos, capacidades, habilidades y actitudes para solucionar problemas del entorno, con análisis crítico, metacognición y ética.
Impacto de programa de televisión “estrategia aprendo en casa” en la educación peruana
Authors: Nontol-Pastor Giovanna Ayure , Duran-Llaro Kony Luby
Published: November 2023

La presente investigación tuvo como propósito interpretar el impacto del programa de televisión “estrategia aprendo en casa” en la educación peruana. El estudio se realizó bajo el enfoque cualitativo, configurado bajo el análisis de contenido, para lo cual se tomó como base la categoría programa de televisión “estrategia aprendo en casa”. La literatura recopilada generó su estudio integral de manera detallada, lo cual implicó la comprensión y decodificación de sus significados en relación a las subcategorías, posturas y definiciones emergentes de diversas apreciaciones. Para ello, se asumió una posición respecto a las posibilidades y limitaciones encontradas en el servicio educativo. Como resultado, desde el sentido prospectivo, la categoría se precisó no sólo como una oportunidad para seguir aprendiendo, sino que a la par, presentó ciertas limitaciones a lo largo del proceso didáctico. Sin embargo, se concluyó que los programas de televisión pueden abanderar un uso pedagógico.
Role Play y Expresión oral del idioma inglés
Authors: Purizaca-Gallo Ada Violeta , Duran-Llaro Kony Luby , Jolay-Benites Judith Angélica , Mora-Aranda Rómulo Saúl
Published: November 2023

El presente estudio tuvo como objetivo analizar el role play y la expresión oral del idioma inglés en estudiantes de educación universitaria. Desde el punto de vista metodológico, la investigación se llevó a cabo bajo el enfoque cuantitativo de tipo descriptivo. Como técnica, se empleó la observación y como instrumento, la escala de Likert. La muestra estuvo constituida por 60 estudiantes y 20 docentes de inglés de distintas universidades. El resultado permitió constatar que esta estrategia constituyó una vía significativa para la fluidez, el incremento de vocabulario, la coherencia y la interacción efectiva entre los hablantes del idioma inglés. En consecuencia, se concluyó que la aplicación del role play condujo al desarrollo de la expresión oral.
Efectos de la música en los aprendizajes para la primera infancia
Authors: Sigüeñas-Rodríguez Ana Carol , Duran-Llaro Kony Luby , Sigüeñas-Rodríguez Carmen Sammanda , Muñoz-Sifuentes Lindsay Sue
Published: November 2023

La música juega un papel importante en el desarrollo integral del ser humano, debido a que activa diferentes áreas del cerebro, propiciando el desarrollo de elementos como el lenguaje, la motricidad, el pensamiento, la atención, la concentración y la autorregulación de las emociones, en el desarrollo del niño. El objetivo del presente estudio es analizar los beneficios del método educativo MAPS en la transferencia de aprendizajes para la primera infancia, 2023. La investigación fue cualitativa y fenomenológica. Para su ejecución, se empleó una entrevista semiestructurada en función de analizar dicho método. El resultado permitió destacar que el método MAPS promovió la transferencia de aprendizajes y se vio reflejado en el desarrollo de la inteligencia sensorial, la inteligencia musical y la psicomotricidad. Por lo tanto, se concluyó que, a partir de su aplicación, se logró el desarrollo personal y escolar desde una visión más amplia e integral.
MINIMUM WAGE: TRENDS AND PRICE LEVEL DYNAMICS IN NIGERIA
Authors: A.S Bakare
Published: November 2023

The consequences of wage increase on macroeconomic variables have been enormous and worrisome and yet the phenomenon has not been well documented for Nigeria as little information currently exists especially on the linkage between wage increase and inflation and how policy can effectively influence real wage in Nigeria. Consequently, this paper illustrated how wage increase might be linked to the price level dynamics in a small structural model of analysis of an emerging economy. The paper employed standard methodological approach, Vector Autoregressive Model, to determine the sources of shock to price level in Nigeria. The Variance Decomposition results showed that increases in the minimum wage have contributed significantly to shocks in employment and inflation rate. It shows that shocks in wages cause unemployment and are necessarily inflationary in Nigeria. The findings and the conclusion of the study suggested the need for the policy makers to curtail excess liquidly in Nigeria and enforce the respect of monetary requirements and fiscal discipline. In the light of this suggestion, the policy makers should evaluate the productivity of labor and ensure that the aggregate supply is increased to offset the increase in minimum wage.
القراءات القرآنية وأثر إبدال حرف من بنية الكلمة بآخر على المعنى
Authors: Newir Yasser El-Sayed El-Sayed
Published: November 2023

الأهداف: يهدف هذا البحث إلى بيان أَثَر إبدال حرف بنائيّ ــ أصلي من حروف الكلمة ــ بآخر في تنوُّعِ القراءاتِ القرآنيَّة المتواترة، وبيان الدلالات المتوجِّهة للكلمتين المختلفَتَيْنِ من جهة، وترابطهما واتساقهما من جهة أخرى؛ وصولًا لإثراء معاني آي الذكر الحكيم.
المنهجية: اتَّبَعتْ الدراسة المنهج الاستقرائي بتوثيق القراءات التي فيها إبدال حرف من بنية الكلمة بآخر من كتب القراءات المتواترة المعتمدة. وتم استخدام منهج تحليل المضمون، ثم المنهج النقدي؛ لبيان الفروق التي بين القراءتَيْنِ والدلالتَيْنِ المختلفتَيْنِ. وتم إحصاء عشر كلمات، كل كلمة منها قُرِئَتْ بقراءتين مختلفتين لفظًا ومعنًا.
النتائج: خلصت الدراسة إلى جملة من النتائج أهمها أَنَّ إبدال حرف من بنية الكلمة بآخر يثري معنى الآية ويوسع دلالاتها، أو تتكامل معنى القراءتين معًا؛ لتعطيان معنًا عامًا للآية الكريمة. أو دَلَّتْ كل قراءة من القراءتين على حَتْمِيّة معنى القراءة الأخرى ووجودها، أو أكدت كل قراءة من القراءتين المعنى العام للآية الكريمة.
الخلاصة: ضرورة العمل على إعمال القراءتين المتواترتين التي فيهما إبدال حرف بآخر من بنية الكلمة في الآية الكريمة. حتى يكون المعنى العام للآية سليمًا. ومتسقًا مع محور السورة وعمودها الرئيس. كما توصي الدراسة بتعميق الأبحاث والدراسات في اختلاف القراءات القرآنية، وعلاقة هذا الاختلاف بتفسير القرآن الكريم واتساع معانيه من جهة، وبيان وجه إعجازه من جهة أخرى.
Robust Bayesian growth curve modeling: A tutorial using JAGS
Authors: Li Ruoxuan
Published: November 2023

Latent growth curve models (LGCM) are widely used in longitudinal data analysis, and robust methods can be used to model error distributions for non-normal data. This tutorial introduces how to modellinear, non-linear, and quadratic growth curve models under the Bayesian framework and uses examples to illustrate how to model errors using t, exponential power, and skew-normal distributions. The code of JAGS models is provided and implemented by the R package runjags. Model diagnostics and comparisons are briefly discussed.
IMPACTOS DA PANDEMIA DE COVID-19 EM EMPRESAS DE TRANSPORTE: UMA ANÁLISE SOB A PERSPECTIVA DE GESTORES
Authors: VELOSO ALENCAR LARA , LUIZ MENDES ATHAYDE ANDRÉ
Published: November 2023

O objetivo deste estudo foi analisar os impactos da COVID-19 em empresas de transporte de Montes Claros-MG na perspectiva de gestores do ramo. Adotou-se uma abordagem qualitativa, não tão utilizada para esse tema, o qual tem sido explorado, mormente, por meio de relatórios quantitativos de órgãos governamentais e de bancos de dados públicos relativos ao tema, tanto nacional quanto internacionalmente. Para tanto, realizaram-se entrevistas semiestruturadas com gestores de empresas de transporte aéreo e terrestre, de cargas e de passageiros. Adotou-se a Análise de Conteúdo para interpretação do corpus textual proveniente das entrevistas transcritas. Dentre outros achados, os resultados apontaram que o transporte de passageiros, tanto aéreo quanto rodoviário, foi o mais impactado negativamente, se comparado ao transporte de cargas, levando as empresas de transporte de passageiros pesquisadas a agirem no sentido de redução de custos para mitigar os efeitos da redução de viagens e da redução de ocupação de veículos e aeronaves. Ademais, os resultados apontaram que as empresas de transporte de cargas, tanto aéreas quanto rodoviárias, não foram afetadas negativamente de forma substancial, haja vista que o transporte de cargas tendeu a permanecer ou até mesmo se elevar, a despeito das restrições de mobilidade social.
Od Redakcji
Authors: Burkiewicz Łukasz
Published: November 2023

Bieżący numer kwartalnika jest wyjątkowy z co najmniej czterech względów o charakterze organizacyjno-administracyjnym. Po pierwsze, Akademia Ignatianum w Krakowie stała się uniwersytetem i od 1 października 2023 r. jej nowa nazwa to Uniwersytet Ignatianum w Krakowie. Po drugie, redakcja czasopisma, idąc z duchem czasu, koncentruje się na formule online, ograniczając znacznie nakład wersji drukowanej, a pozostając w szerokim, otwartym dostępie za pośrednictwem platformy Open Journal Systems w przestrzeni internetowej. Po trzecie, czasopismo decyzją Ministra Edukacji i Nauki podaną w Komunikacie z dnia 17 lipca 2023 r. w sprawie wykazu czasopism naukowych i recenzowanych materiałów z konferencji międzynarodowych otrzymało 140 punktów. W końcu, po czwarte, do dyscyplin parametryzowanych w czasopiśmie zostały włączone – obok już funkcjonujących 1) nauk o kulturze i religii, 2) literaturoznawstwa, 3) historii oraz 4) nauk o zarządzaniu i jakości – kolejne, jak 5) etnologia i antropologia kulturowa, 6) filozofia, 7) językoznawstwo, 8) nauki o sztuce, 9) polonistyka, 10) nauki o polityce i administracji, 11) nauki o komunikacji społecznej i mediach oraz 12) pedagogika.
The Visual Culture of the Selfie from the Perspective of ‘Visual Identity’
Authors: Chmielecki Konrad
Published: November 2023

The essay attempts to outline the issues of the visual culture of the selfie from the perspective of “visual identity” that has referred to contemporary art. In this paper, I analyze examples of the following artworks: The Reincarnation of Saint ORLAN by the French artist ORLAN, the Bodies© INCorporated website, designed by Victoria Vesna, The Little Revenge from the Periphery by José Bedia Valdés, The Chief: He Who Sold Africa to the Colonists and Autoportraits by Samuel Fosso. In addition, this paper is focused on an analysis of the “biopower” concept which refers to Michel Foucault’s “docile bodies.” This concept is based on the neoliberal power process over the production of living beings and exercising control over them is an updating of the development of political, democratic, and economic institutions, as well as information and biocybernetic technologies. The “docile bodies” concept strengthens the conviction of the bodies must become the object of biopower interventions for the “perfect body” concept to act upon the strictly defined appearance of the body consistent with the standards and norms of “beauty” adopted by visual culture. In this situation, the selfie and photographic images produce homogeneous images, which function as “ideological texts” making our “visual identity” and self-image. This concept is given a lot of considerable space in this paper because the selfie can be regarded as an “personality identity” shaping the visual appearance of our bodies. In the essay’s conclusion, I claim that the visual culture of the selfie seems to be an aesthetic phenomenon shaped by a visual medium such as digital photography. However, photography does not is the key medium of the selfie. My analyses were aimed at showing that this role plays an “image,” no matter how it can be understood.
Kandungan Protein, Kekerasan Dan Daya Terima Cookies Tepung Komposit Sagu Baruk (Arenga microcarpa) Dan Kacang Hijau (Vigna radiata)
Authors: Lasaji Hariyati , Assa Jan Rudolf , Taroreh Mercy I. R.
Published: November 2023

Tujuan penelitian ini adalah mengevaluasi kandungan protein, tingkat kekerasan dan daya terima cookies dengan tepung komposit sagu baruk dan kacang hijau. Penelitian ini menggunakan metode RAL (Rancangan Acak Lengkap), yang terdiri dari 4 perlakuan dan 3 pengulangan yaitu sebagai berikut: F0 tepung sagu baruk 100%:0% tepung kacang hijau, F1 tepung sagu baruk 70%:30% tepung kacang hijau, F2 tepung sagu baruk 60%:40% tepung kacang hijau dan F3 tepung sagu baruk 50%:50% tepung kacang hijau. Kemudian dilakukan analisis kadar protein, uji tingkat kekerasan dan daya terima. Hasil penelitian ini menunjukkan bahwa cookies tepung komposit sagu baruk dan kacang hijau menghasilkan kadar protein yaitu F0 didapatkan nilai 2,77%, F1 didapatkan nilai 8,33%, F2 didapatkan nilai 10,17% dan F3 didapatkan nilai 11,86%. Penelitian juga menunjukkan bahwa tingkat kekerasan cookies tepung komposit sagu baruk dan kacang hijau yaitu F0 dengan nilai 6656,16 gf, F1 dengan nilai 5028,33 gf, F2 dengan nilai 3983,57 gf dan F3 dengan nilai 3531,11 gf. Berdasarkan respon panelis terhadap tingkat kesukaan cookies tepung komposit sagu baruk dan kacang hijau dengan respon yang paling disukai panelis adalah campuran tepung sagu baruk 70% dan 30% tepung kacang hijau yang memiliki nilai kesukaan warna 3,75 (suka), rasa 4,01 (suka), aroma 3,59 (suka), tekstur 4,07 (suka) dengan kadar protein 8,33%, kadar air 3,65% dan tingkat kekerasan 5028.33 gf.
Kata kunci: Cookies; Sagu Baruk; Kacang Hijau; Protein; Kekerasan.