bluuebunny/crossref_metadata_2025 huggingface dataset:
THY ye Yönelik Marka Tutkusunun ve Marka Sevgisinin Tüketici Davranışları Üzerindeki Etkisinde Marka İmajının Düzenleyici Rolü (The Moderating Roll of Brand Image on The Effect of Brand Passion and Brand Love For Turkish Airlines on Consumer Behavior)
Authors: Alizade Parisa
Published: October 2024

Amaç –Bu çalışmanın amacı, THY (Türk Hava Yolları) markasına duyulan tutkunun ve sevginin tüketicilerin yüksek fiyatı ödeme isteği, olumlu ağızdan ağıza iletişim ve satın alma niyeti üzerindeki etkisini ve bu ilişkilerde marka imajının düzenleyici rolünü ortaya koymaktır. Yöntem–Bu kapsamda THY’ye duyulan tutkunun ve sevginin tüketicilerin yüksek fiyatı ödeme isteği, ağızdan ağıza iletişim ve satın alma niyeti üzerindeki etkisini ve bu ilişkilerde marka imajının yarattığı düzenleyici etkiyi incelemek amacıyla literatür araştırması yapılarak hipotezler ve kavramsal model ortaya konulmuştur. Çalışmanın anketi Türkiye’de yaşayan ve Türk Hava Yolları’nın müşterisi olan kişilere uygulanmıştır. Çalışmanın modeli elde edilen 453 veri üzerinden test edilmiştir. Regresyon analizi ile çalışmanın hipotezleri test edilmiştir.Bulgular–Çalışma bulguları marka tutkusunun ve marka sevgisinin tüketicilerin yüksek fiyatı ödeme isteği, olumlu ağızdan ağıza iletişim ve satın alma niyeti üzerindeki etkisini ortaya çıkarmıştır. Ayrıca, THY’ye duyulan tutkunun ve sevginin tüketicilerin yüksek fiyatı ödeme isteği, olumlu ağızdan ağıza iletişim ve satın alma niyeti üzerindeki etkisinde marka imajının düzenleyici role sahip olduğu saptanmıştır. Tartışma–Araştırmanın sonuçları tüketicilerin THY’ye yönelik tutku ve sevgi duygularının yüksek fiyatı ödeme isteği, olumlu ağızdan ağıza iletişim ve satın alma niyeti üzerindeki olumlu etkisini ortaya çıkarmıştır. Ayrıca, THY markasına yönelik yüksek seviyede olumlu imaja sahip tüketicilerde marka tutkusu ve marka sevgisi yüksek fiyatı ödeme isteği, olumlu ağızdan ağıza iletişim ve satın alma niyeti üzerinde daha büyük etkiye sahiptir.
Yabancı Sermayeli Gıda Şirketlerinin Gastrodiplomasi Uygulamaları; Türkiye de Yayınlanan Gıda Reklamları Üzerine Bir İnceleme (Gastrodiplomacy Practices of Foreign-owned Food Companies; A Study on Food Advertisements Published in Turkey)
Authors: Şenel Pınar , Yılmaz Hakan , Yumak Bekir
Published: October 2024

Amaç –Ülkelerin mutfak kültür ve ögeleri aracılığıyla farklı ülkelerle olan siyasi, kültürel ve ticari ilişkilerini yönetmesi olarak tanımlanan gastrodiplomasi, son yirmi yılda ülkeler tarafından sıklıkla kullanılmaktadır. Gastrodiplomasi uygulamalarının yaygın olarak ise kitle iletişim araçları üzerinden gerçekleştiği görülmektedir. Araştırmanın amacı, yabancı sermayeli gıda şirketlerinin gastrodiplomasi uygulamalarını, Türkiye’de yayınlanan gıda reklamları üzerinden incelemektir. Yöntem –Çalışmada nitel yöntemlerden faydalanılmıştır. Araştırmada amaçlı örnekleme yöntemiyle belirlenen 34 reklam göstergebilimsel analiz yöntemiyle incelenmiştir. Reklamlara Youtube medya kanalı üzerinden anahtar kelime ile taramalar sonucunda ulaşılmıştır. Ulaşılan reklamlargastrodiplomasiye yönelik içerikleri kapsamında incelenmiştir.Bulgular –Analiz sonucunda yabancı sermayeli şirketlerin reklamlar üzerinden gerçekleştirdiği gastrodiplomasi uygulamalarının en fazla kahvaltılık ve atıştırmalık gıdalar olmak üzere ana yemek ve restoranlara, içeceklere ve yiyecek hazırlamada kullanılan gıdalara yönelik olduğu belirlenmiştir. Ek olarak gastrodiplomasi uygulamalarının en fazla Amerika Birleşik Devletleri olmak üzere İngiltere, Fransa, Hollanda, İtalya, İsviçre ve Almanya sermayeli şirketler tarafından gerçekleştirildiği tespit edilmiştir.Tartışma –Araştırma sonucunda yabancı sermayeli gıda şirketlerinin reklamlarının, ürünlerini pazarlama temel amacı taşımakla birlikte kendi ülkelerinin mutfak kültürü ve ögelerini pazarlamaya ve Türk mutfak kültürü ögelerini yozlaştırmaya yönelik içerikte olduğu tespit edilmiştir. Araştırmayla gastronomi ve iletişim alanındaki disiplinler arası literatüre, Türk televizyon yayıncılığına ve Türk sermayeli gıda şirketlerine yönelik katkılar hedeflenmiştir.
Bölgelerin Pazarlama Faaliyetlerinde Coğrafi İşaretli Ürünlerin Etkisinin İncelenmesi: Karabük Eskipazar Örneği (Investigation of the Effect of Geographically Marked Products in the Marketing Activities of Regions: Karabuk Eskipazar Case)
Authors: Yurt İrfan
Published: October 2024

Amaç –Bu çalışma, "Karadeniz'in Zeugması" olarak adlandırılan Karabük'ün Eskipazar ilçesinin coğrafi işaret tescilli ve tescil alma potansiyelli ürünlerini belirleyerek bu ürünlerin pazarlama faaliyetlerindeki etkisini incelemeyi amaçlamaktadır.Yöntem –Bu çalışma nitel araştırma desenlerinden fenomenoloji/olgu bilim ile yapılmıştır ve veriler yarı yapılandırılmış mülakat yöntemi ile toplanmıştır. Bulgular –Elde edilen verilere göre, coğrafi işaret tescili alma potansiyeline sahip olan Kelem Dolması, Eskipazar Köy Peyniri, Keşkek Çorbası, Cevizli Yahni, Soğan Salması, Kaz Banduması ve Miyane Helvası gibi gastronomik ürünler, pazarlama açısından önemli avantajlar sunmaktadır. Tescilli ürünlerin, bölgenin görünürlüğünü artırdığı, gastronomi turizmini çektiği ve yerel ürünleri daha geniş pazarlarda farklılaştırarak benzersiz bir marka kimliği oluşturduğu görülmüştür. Eskipazar'da mevcut coğrafi işaret tescilli veya başvuru sürecinde olan bir ürün bulunmaması, bu süreçte stratejik destek ve kaynakların sağlanması gerektiğini göstermektedir. Tartışma –Araştırma bulguları, Eskipazar’ın geleneksel mutfak kültürünün yerel halkın beslenme alışkanlıklarına ve günlük yaşamına derin bir şekilde kök saldığını göstermektedir. Coğrafi işaret tescili alma potansiyeli olan bu ürünler, bölgenin gastronomik mirasının korunması ve tanıtılması açısından önemli bir rol oynayabilir. Eskipazar’ın geleneksel yemekleri, gastronomi turizmi açısından da önemli bir potansiyele sahiptir ve bu potansiyelin doğru bir şekilde değerlendirilmesi durumunda yerel ekonomiye ciddi katkılar sağlayabilir.
Mutfak Çalışanlarının Mesleğe Yönelik Tutumlarının Oluşmasında Örgütsel Destek Algısı ve Lider Üye Etkileşiminin Rolü (The Role of Organizational Support Perception And Leader-Member Exchange in The Formation of The Attitudes Towards The Profession of Kitchen Employees)
Authors: Aykaç Emre , Buyruk Lütfi
Published: October 2024

Amaç –İşletmelerde çalışanların sahip olduğu mesleğe yönelik tutumlarının verimlilik ve etkinlik açısından ağır bir role sahip olduğu varsayılmaktadır. Her ne kadar kişilerin sevdikleri işleri yaptıkları düşünülse de dünyadaki misyonunu bulup mesleğine aşık bir insanı etkileyen, her olay veya olguda olduğu gibi birtakım faktörler bulunmaktadır. Bu noktada örgütsel destek algısı ile lider-üye etkileşimi değişkenleri birçok bilimsel araştırma sonucunda organizasyonlar açısından irdelenmesi gereken bir duruma gelmiştir. Bu bağlamda, çalışmada mesleğe yönelik tutumun oluşmasında, algılanan örgütsel destek ve lider-üye etkileşiminin rolünün olduğuna ilişkin varsayımdan yola çıkılarak izahı ortaya konmak istenmiştir. Yöntem -Araştırmanın evreni, Antalya ili ve ilçelerinde faaliyet gösteren beş yıldızlı otel işletmelerinin mutfak çalışanları olarak belirlenmiştir. Araştırmada olasılığa dayalı olmayan örnekleme yöntemlerinden kolayda örnekleme yöntemi kullanılmıştır. Araştırma kapsamında 445 mutfak çalışanı araştırmaya dâhil edilmiş ve anket tekniği kullanılarak araştırma verileri toplanmıştır. Bulgular -Yapılan anket çalışması sonucunda ulaşılan bulgulara göre, mutfak çalışanlarının mesleğe yönelik tutum, örgütsel destek algısı ve lider-üye etkileşimi arasında orta düzeyde pozitif yönlü ve anlamlı bir ilişki bulunmuştur. Ayrıca yol analizi ile elde edilen sonuçlara göre mutfak çalışanlarının hem örgütsel destek algısı hem lider-üye etkileşimi kalitesinin, mesleğe yönelik tutumun oluşmasında önemli bir etkiye sahip olduğu saptanmıştır. Tartışma -Ulusal ve uluslararası literatürde üç değişkeni bir arada etki/ilişki modeli ile analiz eden bu çalışma mesleğe yönelik tutum, algılanan örgütsel destek ve lider-üye etkileşimi değişkenlerinin literatür ve paydaşlar açısından önemine değinmektedir. Bu çalışma, mutfak çalışanlarının mesleğe yönelik tutumlarının, algılanan örgütsel destek ve lider-üye etkileşimi ile olumlu bir ilişkiye sahip olduğunu göstermektedir. Elde edilen bulgular, örgütlerin çalışan memnuniyetini artırmak için liderlik ve destekleyici ortamın önemini vurgulamaktadır. Ancak, araştırmanın sınırlı örneklem büyüklüğü ve sektörel sınırlamaları, sonuçların genellenebilirliğini kısıtlamaktadır. Gelecek çalışmalar, bu bulguları farklı sektörlerde ve kültürel bağlamlarda test ederek genişletmelidir.
Validation of a structured role assignment methodology in group work for engineering courses = Validación de una metodología de asignación estructurada de roles en el trabajo en grupo en asignaturas de ámbito ingenieril
Authors: Linares Maria , Martín-Sómer Miguel , García Alicia , Moreno Inés , Vizcaíno Arturo , Pariente Isabel , Casado Cintia , Pizarro Patricia , Martín-Rengel Antonio , Pablos Cristina , Gómez-Pozuelo Gema , Orcajo Gisela
Published: October 2024

La incorporación de actividades de trabajo en equipo en los programas de formación universitaria es esencial, ya que es una de las habilidades más valoradas para los profesionales en el campo de la ingeniería. La selección de los grupos de trabajo por parte del profesor es una estrategia que puede conducir a un mejor desempeño en las tareas colaborativas. Este estudio presenta los resultados de una investigación sobre los criterios conscientes para la selección de grupos de trabajo basados en los roles de los estudiantes. La investigación tuvo como objetivo analizar las dinámicas de trabajo en equipo entre estudiantes de diversas disciplinas dentro de los cursos de ingeniería. Se examinaron las opiniones de más de 600 estudiantes matriculados en 10 programas de grado y posgrado. Los resultados indican que los estudiantes de cursos avanzados se sienten más cómodos asumiendo el papel de líder, mientras que los estudiantes de primer año no tienen un perfil claramente definido. La evaluación de los estudiantes con esta metodología también muestra ciertas variaciones dependiendo del año y el tipo de actividad. En general, en los grupos con mejor rendimiento, la mayoría de los miembros reciben evaluaciones similares de sus compañeros.AbstractThe incorporation of teamwork activities in university training programs is essential, as it is one of the most valued skills for professionals in the field of engineering. The selection of working groups by the teacher is a strategy that can lead to better performance in collaborative tasks. This study presents the results of research on the conscious selection criteria for group work based on students’ roles. The research aimed to analyze teamwork dynamics among students from various disciplines within engineering courses. The opinions of over 600 students enrolled in 10 undergraduate and postgraduate programs were examined. The results indicate that students in advanced courses feel more comfortable taking on the role of leader, while first-year students do not have a well-defined profile. The evaluation of students using this methodology also shows certain variations depending on the year and type of activity. Overall, in the highest-performing groups, most members receive similar evaluations from their peers.
Seismic analysis for Pohnpei Island, Federated States of Micronesia
Authors: Taylor Oliver-Denzil , Dunbar Joseph
Published: October 2024

The purpose of this study was to determine the seismic hazards that can affect Pohnpei Island and provide estimates of the ground motion parameters. The primary parameters are peak ground acceleration (PGA), pseudo-spectral acceleration (PSA), and velocity. These values were determined both probabilistically and deterministically to illustrate the overall seismic hazard to Pohnpei Island. A review was conducted of the technical literature to determine geologic studies that have been performed for characterization of the island’s volcanism, stratigraphy, and tectonism. This report is a desktop study that examines the tectonism of the region, the geology of the island, its geologic history, and its seismic record. No liquefaction areas or tsunami hazards were identified by researchers on the island.
The study of cases of fixed points of a complex function depending on the inputs and concluding examples of useful functions
Authors: louiz akram
Published: October 2024

This is a mathematical article that deals with the domain of complex numbers in order to present
new results by using a complex function and studying its fixed points.

The aim of this work is to propose mathematical procedures that help to deduce the fixed points of a
complex function. These fixed points can also be used as a basis to generate new useful complex
functions that have for sure at least one fixed point. Hence, this is a good article to be read by
specialists of Calculus and Analysis and even by the beginners of mathematics who want to
improve their skills in the field of complex numbers.
WITHDRAWN: Effects of TgCtwh3 Toxoplasma gondii ROP16 on neuronal apoptosis and β-amyloid production
Authors: Yang Di , Wang Cong , Tao Qing , Liu Lei , Jin Mengmeng , Zheng Meijuan , Gong Mengtao , Yu Li , Du Jian , Luo Qingli , Shen Jilong , Qin Kunpeng , Chu Deyong
Published: October 2024

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Optimality results for nondifferentiable multiobjective fractional programming problems under E-B-invexity
Authors: Mishra S. K. , Singh Dhruv , Kumar Pankaj , Singh Vandana
Published: October 2024

In this study, we address nonconvex multiobjective fractional pro-
gramming problems involving E-differentiable functions (MF PE).
The so-called E-Karush–Kuhn–Tucker suffcient E-optimality conditions
are established for nonsmooth vector optimization problems under
the E-B-invexity hypothesis. To illustrate the established results, we
present an example in which the functions involved are E-B-invex.
MSC Classification: 90C32 , 90C46 , 49J52 , 90C30 , 90C29
Association of Higher Blood Cadmium Level and Fetal Macrosomia among PFAS exposure Participant from NHANES 2017-2018
Authors: Ripon Rezaul Karim
Published: October 2024

Background: Concern about potential reproductive health effects has arisen from the interaction between environmental contaminants such as perfluoroalkyl substances (PFAS) and blood cadmium levels. Exposure to PFAS above the limit of detection impacts the reproductive health of people with elevated blood cadmium levels.
Objective: To analyze the relationship between blood cadmium levels and different reproductive health outcomes in a large cohort exposed to PFAS above the limits of detection, considering sociodemographic factors and reproductive history.
Methods: A community-based cross-sectional study was conducted among 143M NHANES participants from 2017-2018. Descriptive statistics for PFAS exposure were analyzed and bivariate and adjusted regression analyzes were used to evaluate the relationship between blood cadmium levels and reproductive health outcomes. Age, race, educational level, marital status, income-poverty ratio, and reproductive history were variables considered in the analysis.
Results: 16% of participants whose PFAS and blood cd are above the detection limit showed fetal macrosomia. Participants with higher educational levels, particularly college graduates or higher, showed higher odds of experiencing detrimental Blood cadmium above the detection limit (aOR = 1.131, 95% CI: 1.008-1.269, p = 0.0355). Furthermore, people who had never been married were significantly more likely (aOR = 1.305, 95% CI: 1.122-1.518, p = 0.0006), and fetal macrosomia was significantly more likely (aOR = 1.065, 95% CI: 1.007-1.126, p = 0.0285) whose blood cd level is higher.
Conclusion: The results highlight the importance of considering sociodemographic factors when it comes to environmental exposures and their effects on reproductive health. To inform public health interventions aimed at reducing the negative effects of environmental pollutants on reproductive health, future research should further investigate these relationships.
AFAP1L1 is indicative for a grim prognosis and immune microenvironment in gastric cancer
Authors: Gan Lin , Yang Changjiang , Zhao Long , Wang Shan , Ye Yingjiang , Gao Zhidong
Published: October 2024

The biological role of the actin filament associated protein 1 like 1(AFAP1L1) has been investigated in human malignancies, but its function in gastric cancer (GC) is unclear. This research sought to elucidate more about AFAP1L1's biological function in GC and its prognostic relevance by analyzing its expression profiles and prognostic significance using bioinformatic and immunohistochemical analysis based on large-scale databases and clinical samples. The comparative analysis of normal and tumor tissues indicated that the latter had elevated levels of AFAP1L1 expression level, which was linked to dismal survival in GC patients. Multivariate Cox regression analysis showed that elevated AFAP1L1 expression was an independent factor for poor prognosis in GC patients. Functional enrichment analysis including GO, KEGG and GSEA illustrated that AFAP1L1 could act as an oncogene by regulating gene expression in essential functions and pathways of tumorigenesis, such as cell junction, protein kinase activity, angiogenesis-associated pathways, and immune response-associated pathways. Furthermore, immune cell infiltration results showed that AFAP1L1 was associated with the immune infiltration of macrophages and their polarization. In addition, AFAP1L1 was negatively related to the sensitivity of chemotherapy drug oxaliplatin, while positively with dabrafenib, indicating that AFAP1L1 could be used as a predictive marker of the curative effect of GC patients. In conclusion, AFAP1L1 may be employed as a diagnostic and prognostic biological marker, and it also offers more in-depth insights into the establishment of therapies and prognoses in GC individuals.
The impact and predictive value of refeeding syndrome on the short-term prognosis of patients with severe stroke
Authors: Zhang Wei , Zhang Shengxiang , Tang Yun , Zhao Shoucai , Yu Tao
Published: October 2024

Refeeding syndrome (RFS) may have adverse effects on patients. However, the impact of RFS on the prognosis of severe stroke patients remain unclear. This study is aim to explore the impact on short-term prognosis of patientswith severe stroke. A total of 305 patients were included for retrospective analysis. The electrolyte changes and short-term prognosis between RFS and NRFS groups of patients were compared. Besides, the risk factors for prognosisof patients and the predictive efficacy of RFS in patient prognosiswere analyzed. The new acute liver injury (ALI), new acute kidney injury (AKI), new mechanical ventilation (MV), mortality within 28 d, and mRS scores at the discharge were higher in the RFS group than in the NRFS group (P < 0.05). The serum phosphorus level in the RFS group decreased after EN compared to before EN (P < 0.05). The area under the ROC curve (AUC) of RFS for predicting poor prognosis in patients with severe stroke was 0.678, with a sensitivity of 64.7%, and a specificity of 61.4%. RFS is an independent risk factor for the patient’s functional prognosis, therefore, medical staff should screen high-risk populations as early as possible and provide preventive treatment according to the guidelines.
Clinical characteristics of long-term survivors of pleural mesothelioma
Authors: Hashimoto Masaki , Nakamura Akifumi , Nakamichi Toru , Kuroda Ayumi , Takegahara Kyoshiro , Matsumoto Seiji , Kondo Nobuyuki , Fujiwara Masayuki , Kitajima Kazuhiro , Kuribayashi Kozo , Yamakado Koichiro , Kijima Takashi , Hasegawa Seiki
Published: October 2024

Objective To identify the clinical characteristics of long-term survivors (> 5 years) with pleural mesothelioma (PM) who had previously undergone curative-intent surgery.Methods A total of 121 patients with PM undergone curative-intent surgery following neoadjuvant chemotherapy between January 2006 and June 2016were enrolled in this study. Long-term survivors were defined as patients survived > 5 years from the date of diagnosis. We determined the incidence and clinical characteristics of long-term survivors.Results Of 121, 41 (33.9%) survived > 5 years from the date of diagnosis. The median age was 62 years. There were 35 males, 23 right-sided, the performance status (PS) was 0 in 40, and all were epithelioid subtype. Nine had partial responses to neoadjuvant chemotherapy, and 32 had stable disease. The median sum of pleural thickness at three levels was 8.2 mm, 25 patients underwent pleurectomy/decortication, 14 were pathological T1, 33 were pathological node-negative, and 2 had severe postoperative complications (Clavien–Dindo classification grade ≥ 3). Tumor relapse was observed in 31, and the relapse pattern was local only in 21, distant only in 2, and both in 8. Of 31 patients with tumor relapse, chemotherapy was performed in 30. Of the 41 long-term survivors, 24 died from PM, and 3 died from other causes. The median relapse-free survival was 51.4months, and the median post-relapse survival was 45.0 months.Conclusion In our cohort, 33.9% survived > 5 years after diagnosis. The clinical characteristics of long-term survivors were a good candidate (< 70-year-old, PS0), epithelioid subtype, tinner pleural thickness and an uneventful postoperative course.
Water Quality Assessment Using Water Quality Index and Land Use/Land Cover of Saryu River, Kumaon Himalaya, India
Authors: Sharma Madhuben , Rautela Ajay , Rawat Sameeksha , Gurav Ranjit
Published: October 2024

The Saryu River, a branch of the Sharda River (downstream of the Mahakali River), flows in the Kumaon Himalaya. This study utilized the physico-chemical parameters to assess water quality status and calculate the Water Quality Index (WQI), as well as Sentinel-2 satellite images of 10-meter resolution for 2022 and 2023 to analyse land use and land cover (LULC). The secondary water quality data was obtained from the Uttarakhand Pollution Control Board. The results revealed that the total hardness, calcium, magnesium, faecal coliform, and total coliform were beyond the acceptable limits set by Bureau of Indian Standards/World Health Organization. Ions are primarily released in water via the process of carbonate weathering. In both the seasons of 2022 and 2023, the concentration of the analysed cation and anion followed the sequence of calcium > magnesium > sodium > potassium, and sulphate > chloride > fluoride > nitrate-nitrogen, respectively. In both years, the WQI showed good water quality. The LULC shows the negative change detection of water (-0.31%), built area (-0.84%) and rangeland (-0.98%), whereas trees (+ 1.05%), crops (+ 0.39%) and bare ground (+ 0.69%) show positive change detection from 2022 to 2023. According to the study's findings, the Saryu River water is safe for drinking. However, the presence of faecal coliform and total coliform highlighted the need for enhanced sanitary infrastructure and protocols to mitigate bacterial contamination from river water.
NEoAdjuvant Radiohormonal Therapy Versus Standard of Care for Oligometastatic Prostate Cancer (NEAR-TOP): Study protocol of a multicenter, open-label, randomised controlled trial
Authors: Fan Zhiguo , Li Duocai , Yan Shi , Zhao Xianzhi , Yin Lei , Xu Weidong , Wang Ye , Zhang Huojun , Chang Yifan , Ren Shancheng
Published: October 2024

Background: Metastatic prostate cancer is commonly treated with androgen deprivation therapy (ADT) and chemotherapy, which often leads to treatment resistance and disease progression with limited effective interventions. Recent advances in robotic surgery and precision radiotherapy have prompted research into comprehensive treatments for low-burden metastatic prostate cancer, particularly oligometastatic prostate cancer (OMPC). Our phase I/II clinical study confirmed the safety and efficacy of neoadjuvant radiotherapy combined with endocrine therapy before radical prostatectomy, warranting further investigation.
Methods: This study protocol outlines a prospective, open-label, multicenter, randomized controlled trial to evaluate preoperative neoadjuvant radiohormonal therapy versus standard care in OMPC. The experimental group receives LHRHa, abiraterone, IMRT for pelvic lesions, and SBRT for extrapelvic lesions, followed by RARP and lymph node dissection. The control group receives long-term LHRHa and abiraterone. The primary endpoint is 3-year failure-free survival (FFS), and secondary endpoints include time to CRPC, 2-year FFS, OS, TRG rating, and complications.
Conclusion: This trial is the first to assess whether neoadjuvant radiohormonal therapy with robotic prostatectomy offers better prognostic outcomes than long-term endocrine therapy alone for OMPC. The results aim to provide high-level evidence for this approach, potentially influencing future treatment protocols.
Trial registration: The study has been registered on clinicaltrials.gov (NCT05707468).
Carbon Footprint Assessment and Reconstruction Redesign of Recycled Discarded Military Training Uniforms
Authors: Huang Ge , Shi Sheng , Wang Qiaoling , Li Fei , Li Xiaoyan , Liu Feng , Lu Zhiwen
Published: October 2024

In response to the problem of resource waste and environmental pollution caused by the large amount of waste textiles in China, taking waste military training uniforms as an example, a thorough investigation was conducted to draw a life cycle diagram of military training uniforms, establish a recycling system for waste military training uniforms, and use Taiyuan University of Technology as a pilot for recycling. The carbon footprint of different recycling methods was calculated. A systematic method for the reorganization and redesign of discarded clothing, starting from clothing styling, has been developed. Utilizing discarded military training uniforms and other discarded textiles, practical applications have been completed in seven aspects: silhouette, style, segmentation, and components. Finally, based on the problems encountered during the pilot recycling and the insights gained from the restructuring and redesign, a derivative theoretical study was completed. Through the study of the carbon footprint of clothing lifecycle and recycling stages, the importance of reusing discarded clothing has been clarified in the form of data. The innovative "1A2B3C" principles for the recycling and redesign of discarded clothing have been proposed, providing a solid theoretical basis and practical experience for the secondary transformation of discarded clothing. The reuse of discarded military training uniforms has been promoted, and the lifecycle of military training uniforms has been extended from the source of the masses.
Six-year follow-up of phase II study exploring chemo-free treatment association with idelalisib and obinutuzumab in symptomatic relapsed/ refractory patients with Waldenström’s macroglobulinemia
Authors: Tomowiak Cécile , Poulain Stéphanie , Nudel Morgane , Feugier Pierre , Herbaux Charles , Mahé Béatrice , Morel Pierre , Aurran Thérèse , Tournilhac Olivier , Leprêtre Stéphane , Assaad Souad , Villemagne Bruno , Casasnovas Olivier , Lhermitte A. , Roos-Weil Damien , Torregrosa-Diaz José , Chevret Sylvie , Leblond Véronique
Published: October 2024

We present the 6-year update of a phase 2 study evaluating the combination of obinutuzumab and idelalisib in relapse/refractory Waldenstrom macroglobulinemia. The results of the REMODEL trial showed interesting efficacy in a high-risk genotype profile population. The primary endpoint was achieved with median PFS of 25.4 months (95% CI, 15.7 to 29.0). However, a major limitation of idelalisib is its toxicity. With median follow-up of 70.9 months, median OS was still not reached, and 5-year OS was 72.9% (95% CI, 61.3 to 86.6). We confirm that CXCR4 mutations had no impact on PFS or OS. However, TP53 mutated patients had shorter OS. At time of analysis, six patients are alive without relapse and 40 progressed. Among the 38 patients who received a new treatment, median time PFS2 was not reached in ibrutinib treated patients (n = 17) versus 30.8 months in patients treated with other options (95% CI, 16.9 to NA), p = 0.005. With longer follow-up our prospective study is the first to show an impact of TP53 mutations in patients treated with fixed duration chemo-free regimen leading to a significant shorter OS in this population. Moreover, ibrutinib remains an effective treatment after this association. This study was registered on the clinicaltrial.gov web (NCT02962401, November 9, 2016).
Managing type 2 diabetes during the COVID-19 pandemic in Ghana: A qualitative study
Authors: Amankwah-Poku Margaret , Gordon-Mensah Genevieva , Asante Kwaku Oppong
Published: October 2024

Background
The COVID-19 pandemic has impacted the lives of many including individuals living with chronic illnesses such as Type 2 Diabetes Mellitus (T2DM) in Ghana. This study aimed to explore how people living with T2DM managed their chronic condition during the COVID-19 pandemic.
Methods
This study employed the phenomenological approach where interviews were conducted among 10 participants at the Korle-Bu Teaching Hospital in Ghana. A semi-structured interview guide was used to explore the experiences of participants during the pandemic, focusing on participants’ perceptions about COVID-19 and diabetes management, adherence to treatment regimen during the pandemic, experiences of psychological distress and coping strategies employed. The interviews were transcribed and analysed thematically.
Results
Four themes were identified related to participants’ experiences during the COVID-19 pandemic. These were 1) participants’ perceptions about COVID-19, 2) changes and challenges with diabetes management, 3) psychosocial impact of COVID-19, and 4) coping with diabetes care during the pandemic. Some participants perceived that having diabetes meant they would automatically get infected with COVID-19. All the participants reported experiencing challenges with their diabetes management during the pandemic though a few of them recorded improvements in diabetes management. Psychosocial effects reported were stigmatisation, fear, worry and sadness, due to the ban on social gatherings. Notwithstanding these psychosocial challenges, participants indicated that maintaining diabetes care, engaging in recreational activities, support from family, and religious coping, were strategies used to lessen the COVID-19 psychological distress experienced.
Conclusion
Findings suggest that people with T2DM should be given psychological support and psychoeducation on appropriate coping skills during pandemics and other unexpected occurrences that could affect their diabetes management.
How tidal properties influence the future duration of coastal flooding
Authors: Talke Stefan
Published: October 2024

In this manuscript, we explore how tidal properties influence the duration of coastal flooding, and therefore impact. We find analytically that 4 factors impact the duration of the high-water stand: the dominant tide-wave period, the maximum water-level above a datum, the tidal amplitude, and the interaction of diurnal and semidiurnal tidal amplitudes and phases. Some regions—such as the US Gulf Coast—have a combination of tidal properties that leads to long flood durations (>20 hours) for modest inundation depths (e.g., 0.2m). Regions with large semidiurnal tides (such as Gulf of Maine) are inundated for only 1-2 hours, for the same depth of flooding. Within individual estuaries, the potential duration of a 0.2m minor flood event varies by a factor of more than two (e.g., San Francisco Bay, Chesapeake Bay). Combined with relative sea-level rise (RSLR) rates that vary from less than 0 mm/yr to 10 mm/yr around North America, the observed timescale to transition from a zero to two hour flood length varies from 1-87 years. This large spatial variability in tidal inundation properties has implications for hazard planning, ecological adaptation and the future evolution of coastal flood events.
Research on Improving Ethical Sensitivity for Ethical Decision-Making in Conversational AI
Authors: Yoo Kyungsun , Ahn Seongjin
Published: October 2024

The development of large language models has significantly advanced the inferential capabilities of artificial intelligence (AI), surpassing human-level performance. Despite the rapid growth in AI's cognitive abilities and the consequent expectations for high-level ethical judgments, ethical issues have increased. This indicates a heightened risk of bias as AI models scale up and train on vast amounts of general data that inherently include social conventions related to gender, race, politics, and religion. This study proposes methods for enhancing ethical sensitivity to social bias. To achieve this, we defined 20 categories of social bias and developed a model that predicts the ethical sensitivity of sentences by leveraging the influence scores of words within these categories. The ethical sensitivity prediction model was validated using a paired-sample t-test, comparing the ethical sensitivity evaluations of 25 AI-generated responses assessed by both AI and human evaluators. The test revealed no significant differences between the two groups, thus confirming the validity of the model. The findings of this study suggest that recognizing and predicting the ethical sensitivity of utterances concerning social biases can enhance ethical sensitivity, mitigate the risk of bias, and contribute to more ethical decision-making in AI interactions.
Addressing Zero-Inflated Scores in Self-Reported Psychiatric Questionnaires: Utilizing Synthetic Minority Over-Sampling Technique (SMOTE) to Classify Mood and Energy Based on Extreme Activity Levels for Adolescents with Bipolar and ADHD
Authors: Bertocci Michele , Vahedifard Farzan , Iyengar Satish , Birmaher Boris , Wolfe Maria , Lepore Brianna , Chobany Mariah , Abdul-waalee Halimah , Malgireddy Greeshma , Hart Jonathan , Diler Rasim
Published: October 2024

Accurate classification of bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD) in adolescents is challenging due to symptom overlap and the prevalence of zero-inflated bias in self-report questionnaires. This study tests machine learning algorithms with and without Synthetic Minority Over-sampling Technique (SMOTE) to solve classification problems.
We analyzed data from 354 adolescent psychiatric inpatients between 2014 and 2023 diagnosed with BD, ADHD, or other psychiatric conditions. Self-reported mood scores and energy scores were categorized into four severity classes and machine learning models, with and without SMOTE, were tested to address zero inflation and correct class imbalances in the scores. Actigraphy was mapped onto these categories.
Applying SMOTE improved the cross-validated overall classification performance across all labels, with accuracy increasing from 58% to 98%, and substantial enhancements in F1 score, precision, and recall, particularly for minority classes. This approach not only boosts the models' sensitivity to minority classes but also enhances the accuracy and reliability of mood and energy assessments in clinical settings for adolescents with BD and ADHD.
Genome-wide CRISPRi-seq identified ferredoxin-NADP reductase FprB as a synergistic target for gallium therapy in Pseudomonas aeruginosa
Authors: Liu Xue , Zhang Yu , Zhang Tingting , Xiao Xue , Kawalek Adam , Ou Jinzhao , Ren Anmin , Sun Wenhao , de Bakker Vincent , Liu Yujie , Li Yuelong , Yang Liang , Jia Ning , Veening Jan-Willem , Wang Yejun , Ye Liang
Published: October 2024

With the rise of antibiotic-resistant bacteria, non-antibiotic therapies like gallium are increasingly gaining attention. Gallium ions exhibit potent activity against multidrug-resistant bacteria and intravenous gallium nitrite is under phase 2 clinical trials to treat chronic Pseudomonas aeruginosa infections in cystic fibrosis patients. However, its clinical efficacy is constrained by the achievable peak concentration in human tissue. To address this limitation, we applied a genome-wide CRISPR interference approach (CRISPRi-seq), to identify potential synergistic targets with gallium. Through the systemic screening, we classified the essential genes by response time and growth reduction, pinpointing the most vulnerable therapeutic targets in this species. In addition, we identified a highly conserved gene fprB, encoding a ferredoxin-NADP+ reductase, the downregulation of which dramatically sensitized the cells to gallium. Using a null mutant, we confirmed the loss of fprB lowers the minimum inhibitory concentration of gallium from 320 µM to 10 µM and shifted gallium’s mode of action from bacteriostatic to bactericidal. Further investigation revealed that FprB plays a critical role in modulating oxidative stress induced by gallium, via control of the iron homeostasis and reactive oxygen species accumulation. Deleting fprB also enhanced gallium's efficacy against biofilms formation and improved outcomes in murine lung infection model of P. aeruginosa, suggesting FprB as a promising drug target in combination with gallium. Overall, our data showed CRISPRi-seq as a powerful tool for systematic genetic analysis of P. aeruginosa, advancing identification of novel therapeutic targets.
Papillary thyroid carcinoma in young patients in Tunisia: clinico-pathological characterization and treatment response
Authors: Houcine Yoldez , Sioud Rania , Elfekih Sirine , Salma Kamoun , Methneni Alia , Dhambri Sawssen , Driss Maha
Published: October 2024

Introduction:
This study aims to investigate factors influencing survival in patients under 40 years old.
Methods:
A retrospective, study conducted at the Salah Azaiez Institute in Tunis.
Results:
Forty patients were selected. The average age was 26.57 years with a sex ratio of 0.14. Multifocality was observed in 50% of cases and some tumors had extra-thyroid extension (12%). Papillary architecture was present in the majority of cases (82%). CPTC was the most common histological type (90%). Coexistence of different nuclear atypia was observed in 32% of cases. The majority of carcinomas (85%) had a low mitotic count (<5mitosis/10CFG). Tumor necrosis was observed in 20% of cases. Angioinvasion was observed in 20% of cases. Lymph node metastases were present in 57% of patients. Nine patients had relapsed (between 2 and 14 months). Analysis of clinical and epidemiological factors showed a trend towards better survival in female patients and patients under 27 years old, with p-values close to significance, respectively (p=0.08, p=0.09).
Conclusions:
The histopathological prognostic factors recently put forth by the new WHO classification in 2022 may not be as applicable to patients under 40 years old.
Cytoplasmic NAD/H synthesis via NRK1 controls CD4+ T cell ROS homeostasis, regulating inflammatory capacity and promoting survival
Authors: Dimeloe Sarah , Stavrou Victoria , Ali Myah , Gudgeon Nancy , Bishop Emma , Fulton-Ward Taylor , Turley Bethany , Heising Silke , Mohamed Sally , Porter Sofia Hain , George Lorna , Davies Scott , Marzullo Bryan , Deng Minghao , Tennant Daniel , Doig Craig , Lavery Gareth , Drummond Rebecca
Published: October 2024

T cell metabolism increases upon activation, underpinning immune effector functions. Nicotinamide adenine dinucleotide (NAD/H) is an essential redox cofactor for glycolysis and mitochondrial substrate oxidation. It is also phosphorylated to NADP/H, which regulates reactive oxygen species (ROS) abundance. NAD/H levels increase upon T cell activation, but synthesis pathways and implications are not fully characterised. Here, we interrogated the role of the NAD/H-synthesis enzyme nicotinamide riboside kinase 1 (NRK1), the expression of which increases upon human and murine CD4+ T cell stimulation. Functionally, NRK1 activity restrains CD4+ T cell activation and cytokine production and promotes survival. These activities are linked to increased NRK1 expression in the cytoplasm, where it locally elevates NAD/H levels. This supports glycolysis, but more profoundly impacts cytoplasmic NADP/H generation, thereby controlling ROS abundance and nuclear NFAT translocation. During invasive fungal infection, T cell-intrinsic NRK1 maintains effector CD4+ T cell frequencies within affected tissues, thereby permitting infection control. Taken together these data confirm that subcellular regulation of immune cell metabolism determines whole organism immune responses.
Evaluating an Intervention to Promote Access to Mental Healthcare for Low Language Proficient Migrants and Refugees across Europe (MentalHealth4All): A Study Protocol
Authors: Lent Liza G.G. , Hodakova Sona , Hanft-Robert Saskia , Mösko Mike , Rao Chiara , Kerremans Koen , Cox Antoon , Gutiérrez Raquel Lázaro , Temizöz Özlem , Mankauskienė Dalia , Biel Łucja , Maria Emilio Di , Schouten Barbara C. , Consortium MentalHealthAll
Published: October 2024

Background
Migrants and refugees with low language proficiency (LLP) have a higher risk of experiencing certain mental health disorders compared to non-migrant populations. They are also more likely to experience a lack of access to mental healthcare due to language- and culture-related barriers. As part of the MentalHealth4All project, a digital multilingual communication and information platform was developed to promote access to mental healthcare for LLP migrants and refugees across Europe. This paper describes the study protocol for evaluating the platform in practice, among both health and/or social care providers (HSCPs) and LLP migrants and refugees.
Methods
We will conduct a pretest-posttest cross-national survey study to perform the platform’s effect-evaluation (primary objective) and process-evaluation (secondary objective). The primary outcomes (measured at T0, T2 and T3) are four dimensions of access: availability, approachability, acceptability, and appropriateness of mental healthcare. Secondary outcomes (measured at T2) are: actual usage of the platform (i.e. tracking data), ease of use, usefulness of content, comprehensibility of information, attractiveness of content, and emotional support. Participants will be recruited from nine European countries: Belgium, Germany, Italy, Lithuania, the Netherlands, Poland, Slovakia, Spain, and the United Kingdom. Using convenience sampling through professional networks/organisations and key figures, we aim to include at least 52 HSCPs (i.e. 6-10 per country), and 260 LLP migrants (i.e. 30-35 per country). After completing a pretest questionnaire (T0), participants will be requested to use the platform and HSCPs will participate in an additional personalised training (T1). Next, participants will fill out a posttest questionnaire (T2), and will be requested to participate in a second posttest questionnaire (T3, about 6-8 weeks after T2) to answer additional questions on their experiences through a brief phone interview (T3 is optional for migrants/refugees).
Discussion
The findings of this prospective pretest-posttest cross-national study will deepen our understanding of how a multilingual platform may promote access to mental healthcare services for LLP migrants and refugees. If successful, this intervention could be used to improve access to mental healthcare services, as well as HSCPs’ competencies in delivering such services, for any LLP migrants and refugees across Europe (and beyond).
Prevalence of Disorder of Villous Maturation and the Pattern of CD15 Immunohistochemical Expression in Placentas with Late Intrauterine Fetal Death
Authors: saba Sayedatus , Begum Shahnaj , Ferdous Jesmin Naz , Billah Md. Mustain
Published: October 2024

Background
Disorder of villous maturation is one of the main reasons for antenatal hypoxia and fetal deaths. Meticulous microscopic and CD15 immunohistochemical studies of such cases may provide valuable information regarding the cause of intrauterine fetal deaths (IUFDs), can help to avoid diagnostic dilemmas and can offer potential treatment options for its prevention in future pregnancies.
Objective
To determine the types of disorders associated with villous maturation in the placenta in late intrauterine fetal death patients, identify delayed villous maturation via histopathological and CD15 immunohistochemical studies and determine its association with recurrent pregnancy loss.
Method
A cross-sectional study was carried out in the Department of Pathology, Sir Salimullah Medical College Mitford Hospital, Dhaka, from March 2021 to January 2023. A total of 80 patients with late IUFDs were included in this study. The placentas of the dead newborns were histopathologically analyzed, and CD15 immunohistochemistry was performed.
Result
Among the 80 patients, 40 (50.0%) were multiparas, 36 (45.0%) were primis, and only 4 (5.0%) were grand multipara patients. Twenty (25.0%) patients had a history of one IUFD, and 4 (5.0%) patients had a history of multiple IUFDs. Twenty-eight (35%) patients had disorders of villous maturation, among whom 19 (23.8%) had delayed villous maturation (DVM), 4 (5.0%) had malformed villi, 3 (3.8%) had distal villous hypoplasia, 1 (1.3%) had deficiency of intermediate villi and 1 (1.3%) had accelerated villous maturation. CD15 immunostaining was performed in 53 patients, including villitis of unknown origin, disorders of villous maturation and villous edema. Among them, 34 (64.15%) had negative CD15 expression, whereas 19 (35.8%) had positive CD15 expression. All 19 patients with delayed villous maturation had positive CD15 expression (100%), which confirmed their histological diagnosis and ensured the complete exclusion of other false positive cases. Among them, 8 (42.1%) had moderate CD15 expression, and 11 (57.89%) had severe CD15 expression. Among the 13 multipara patients with DVM, 12 (92.3%) had a history of previous IUFD. Among the remaining 31 multipara patients with no DVM, 11 (35.5%) had a previous history of IUFD. A significant difference in history of previous IUFD was observed between the DVM present and absent groups (p = 0.001).
Conclusion
This study revealed that disorders of villous maturation are among the main causes of late IUFD and that DVM shows a distinctive pattern of CD15 immunohistochemical expression. Moreover, this study shed light on the association between DVM and recurrent pregnancy loss. The identification of DVM can guide physicians in decision making regarding the management of the patients and prevention of further pregnancy losses.