bluuebunny/crossref_metadata_2025 huggingface dataset:
Protective function of maternal care against egg predators in the shield bug Sastragala esakii (Hemiptera: Acanthosomatidae)
Authors: Nishimura Kou , Kudo Shin‐ichi , Hosokawa Takahiro
Published: June 2023

Females of many acanthosomatid shield bugs attend eggs and young nymphs by covering them with their bodies. Although such form of maternal care has been suggested to have evolved independently in four genera, Elasmucha, Sastragala, Acanthosoma and Sinopla, previous studies exploring its adaptive function have solely focused on species of Elasmucha. This study pioneered an experimental examination of maternal care in the Japanese species Sastragala esakii. Field experiments demonstrated that unattended egg masses suffered intense predation, whereas egg masses attended by their mothers were rarely preyed upon. The ant Crematogaster sp. was the most common egg predator, while two other insect species were also observed to prey on eggs. The exclusion of ant workers and other walking predators from accessing egg masses through the utilization of a sticky trap resulted in a remarkably improved egg survival rate in orphaned egg masses, suggesting that, at least in our study site, maternal care of S. esakii primarily functions to protect eggs from walking predators. Laboratory observations revealed that egg protection against predators was achieved through at least two distinctive defensive behaviors shown by egg‐tending females: (i) tilting their bodies when approached by predators; and (ii) fanning their wings when in contact with predators. However, females displayed a limited response to predators approaching from the posterior direction, suggesting that visual cues play a significant role in predator recognition. These results indicate a similarity in the maternal care functions between Elasmucha and Sastragala, and suggest the parallel evolution of female defensive behaviors.
Nematode biomass changes along an elevational gradient are trophic group dependent but independent of body size
Authors: Li Guixin , Wilschut Rutger A. , Luo Shuaiwei , Chen Han , Wang Xiangtai , Du Guozhen , Geisen Stefan
Published: June 2023

Aboveground, large and higher trophic‐level organisms often respond more strongly to environmental changes than small and lower trophic‐level organisms. However, whether this trophic or size‐dependent sensitivity also applies to the most abundant animals, microscopic soil‐borne nematodes, remains largely unknown. Here, we sampled an altitudinal transect across the Tibetan Plateau and applied a community‐weighted mean (CWM) approach to test how differences in climatic and edaphic properties affect nematode CWM biomass at the level of community, trophic group and taxon mean biomass within trophic groups. We found that climatic and edaphic properties, particularly soil water‐related properties, positively affected nematode CWM biomass, with no overall impact of altitude on nematode CWM biomass. Higher trophic‐level omnivorous and predatory nematodes responded more strongly to climatic and edaphic properties, particularly to temperature, soil pH, and soil water content than lower trophic‐level bacterivorous and fungivorous nematodes. However, these differences were likely not (only) driven by size, as we did not observe significant interactions between climatic and edaphic properties and mean biomasses within trophic groups. Together, our research implies a stronger, size‐independent trophic sensitivity of higher trophic‐level nematodes compared with lower trophic‐level ones. Therefore, our findings provide new insights into the mechanisms underlying nematode body size structure in alpine grasslands and highlight that traits independent of size need to be found to explain increased sensitivity of higher trophic‐level nematodes to climatic and edaphic properties, which might affect soil functioning.
Unintentional designs in ecology: The case of river Periyar in Kerala
Authors: Varghese Mathew A.
Published: June 2023

This paper moves across the ecological assemblages of the Periyar basin in Kerala. It argues that the connectivities and unintentional designs that emerge bespeak the Anthropocene in its regional and political peculiarities. The river has never been a conduit of water alone. The narrative builds broadly on ecological relations entrenched in history, most visibly as hydrological regimes. Such regimes are significant because of the riparian densities that articulate the geo‐morphology. The different entanglements in ecology, as well as the successive productions of natures, gain significance as ‘recognitions’ during rupture events like the large floods. In contemporary contexts, the versatile flows of capital dissolve markers and boundaries and reconfigure regions in terms of capital. Vikasanam or new urban reforms, apart from political policies, are also ecological designs that normalise exceptions, otherwise reserved for special economic zones. The frictions with new materiality, post dam floods and hydrological controls, during developmental and neoliberal post developmental phases, become moments of recognition, making and unmaking sense of place.
A plague passing over: Clinical features of the 2022 mpox outbreak in patients of color living with HIV
Authors: Momin Zoha K. , Lee Aleuna , Vandergriff Travis W. , Bowling Jason E. , Chamseddin Bahir , Dominguez Arturo , Hosler Gregory A. , Wang Richard C. , Kitchell Ellen
Published: June 2023

Introduction

Compared with previous geographically localized outbreaks of monkeypox (MPOX), the scale of the 2022 global mpox outbreak has been unprecedented, yet the clinical features of this outbreak remain incompletely characterized.

Methods

We identified patients diagnosed with mpox by polymerase chain reaction (PCR;n = 36) from July to September 2022 at a single, tertiary care institution in the USA. Demographics, clinical presentation, infection course, and histopathologic features were reviewed.

Results and Conclusion

Men who have sex with men (89%) and people living with HIV (97%) were disproportionately affected. While fever and chills (56%) were common, some patients (23%) denied any prodromal symptoms. Skin lesions showed a wide range of morphologies, including papules and pustules, and lesions showed localized, not generalized, spread. Erythema was also less appreciable in skin of colour patients (74%). Atypical clinical features and intercurrent skin diseases masked the clinical recognition of several cases, which were ultimately diagnosed by PCR. Biopsies showed viral cytopathic changes consistent with Orthopoxvirus infections. All patients in this case series recovered without complications, although six patients (17%) with severe symptoms were treated with tecovirimat without complication.
Chimeric antigen receptor T‐cells: Properties, production, and quality control
Authors: Ramesh Pooja , Hui Henry Y. L. , Brownrigg Leon M. , Fuller Kathy A. , Erber Wendy N.
Published: June 2023

Chimeric antigen receptor (CAR) T‐cell therapy is a novel adoptive T‐cell immunotherapy for haematological malignancies. First introduced into clinical practice in 2017, CAR T‐cell therapy is now finding its place in the management of lymphoid malignancies, primarily of B‐cell lineage, including lymphoblastic leukaemia, non‐Hodgkin lymphoma and plasma cell myeloma, with remarkable therapeutic outcomes. CAR T‐cells are a customised therapeutic product for each patient. Manufacture commences with collection of autologous T‐cells, which are then genetically engineered ex vivo to express transmembrane CARs. These chimeric proteins consist of an antibody‐like extracellular antigen‐binding domain, to recognise specific antigens on the surface of tumour cells (e.g. CD19), linked to the intracellular co‐stimulatory signalling domains of a T‐cell receptor (e.g. CD137). The latter is required for in vivo CAR T‐cell proliferation, survival, and durable efficacy. Following reinfusion, CAR T‐cells harness the cytotoxic capacity of a patient's immune system. They overcome major mechanisms of tumour immuno‐evasion and have potential to generate robust cytotoxic anti‐tumour responses. This review discusses the background to CAR T‐cell therapies, including their molecular design, mechanisms of action, methods of production, clinical applications and established and emerging technologies for CAR T‐cell evaluation. It highlights the need for standardisation, quality control and monitoring of CAR T‐cell therapies, to ensure their safety and efficacy in clinical management.
Risk factors for surgical site infection in patients with gastric cancer: A meta‐analysis
Authors: Chen Muxin , Liang Hao , Chen Meiying , Wang Mingxin , Lin Lijun , Zhou Chunjiao , Wei Lin
Published: June 2023

Surgical Site Infection (SSI) is one of the common postoperative complications after gastric cancer surgery. Previous studies have explored the risk factors (such as age, diabetes, anaemia and ASA score) for SSI in patients with gastric cancer. However, there are large differences in the research results, and the correlation coefficients of different research results are quite different. We aim to investigate the risk factors of surgical site infection in patients with gastric cancer. We queried four English databases (PubMed, Embase, Web of Science and the Cochrane Library) and four Chinese databases (China National Knowledge Infrastructure, Chinese Biological Medicine Database, Wanfang Database and Chinese Scientific Journal Database (VIP Database)) to identify published literature related to risk factors for surgical site infection in patients with gastric cancer. Rev Man 5.4 and Stata 15.0 were used in this meta‐analysis. A total of 15 articles (n = 6206) were included in this analysis. The following risk factors were found to be significantly associated with surgical site infection in gastric cancer: male (OR = 1.28, 95% CI [1.06, 1.55]), age >60 (OR = 2.75, 95% CI [1.65, 4.57]), smoking (OR = 1.99, 95% CI [1.46, 2.73]), diabetes (OR = 2.03, 95% CI [1.59, 2.61]), anaemia (OR = 4.72, 95% CI [1.66, 13.40]), preoperative obstruction (OR = 3.07, 95% CI [1.80, 5.23]), TNM ≥ III (OR = 2.05, 95% CI [1.56, 2.70]), hypoproteinemia (OR = 3.05, 95% CI [2.08, 4.49]), operation time ≥3 h (OR = 8.33, 95% CI [3.81, 18.20]), laparotomy (OR = 2.18, 95% CI [1.61, 2.94]) and blood transfusion (OR = 1.44, 95% CI [1.01, 2.06]). This meta‐analysis showed that male, age >60, smoking, diabetes, anaemia, preoperative obstruction, TNM ≥ III, hypoproteinemia, operation time ≥3 h, open surgery and blood transfusion were the risk factors for SSI in patients with gastric cancer.
Structural relaxation dynamics of a silicate glass probed by refractive index and ionic conductivity
Authors: Lancelotti Ricardo Felipe , Rodrigues Ana Candida Martins , Zanotto Edgar Dutra
Published: June 2023

Relaxation occurs spontaneously in all glasses and is a fundamental step of important technological processes, such as annealing, crystal nucleation, and chemical strengthening by ion exchange. Despite extensive studies over the past decades, there are still conflicting results on whether the kinetics of structural relaxation depends on the analyzed property. Thus, in this study, we used a lithium disilicate glass as a model composition to determine the structural relaxation kinetics during physical aging experiments by measuring the time evolution of the refractive index and ionic conductivity down to 35 K below the initial fictive temperature. In all cases, variations in these properties were adequate to capture the structural changes throughout the aging experiments. At each temperature, the experimental relaxation data fit quite well with the classical stretched exponential relation. We also found that the relaxation process starts faster when probed by ionic conductivity than by refractive index; however, they show similar average relaxation times. These very small structural rearrangements are always the same, but ionic conductivity changes faster than refractive index at the beginning of the process. Our comprehensive results strongly indicate that relaxation dynamics is indeed dependent on the analyzed property.
Impact of baseline pool impedance on lesion metrics and steam pops in catheter ablation
Authors: Takigawa Masateru , Yamamoto Tasuku , Amemiya Miki , Martin Claire A. , Ikenouchi Takashi , Yamaguchi Junji , Negishi Miho , Goto Kentaro , Shigeta Takatoshi , Nishimura Takuro , Tao Susumu , Miyazaki Shinsuke , Goya Masahiko , Sasano Tetsuo
Published: June 2023

Introduction

Little is known about the impact of blood‐pool local impedance (LI) on lesion characteristics and the incidence of steam pops.

Methods

Radiofrequency applications at a range of powers (30, 40, and 50 W), contact forces (CF) (5, 15, and 25 g), and durations (15, 30, 45, and 120 s) using perpendicular/parallel catheter orientation were performed in 40 excised porcine preparations, using a catheter capable of monitoring LI (StablePoint©, Boston Scientific). To simulate the variability in blood‐pool impedance, the saline‐pool LI was modulated by calibrating saline concentrations. Lesion characteristics were compared under three values of saline‐pool LI: 120, 160, and 200 Ω.

Results

Of 648 lesions created, steam pops occurred in 175 (27.0%). When power, CF, time, and catheter orientation were adjusted, ablation at a saline‐pool impedance of 160 or 200 Ω more than doubled the risk of steam pops compared with a saline‐pool impedance of 120 Ω (Odds ratio = 2.31; p = .0002). Lesions in a saline‐pool impedance of 120 Ω were significantly larger in surface area (50 [38–62], 45 [34–56], and 41 [34–60] mm2 for 120, 160, and 200 Ω, p < .05), but shallower in depth (4.0 [3–5], 4.4 [3.2–5.3], and 4.5 [3.8–5.5] mmfor 120, 160, and 200 Ω, respectively, p < .05) compared with the other two settings. The correlation between the absolute LI‐drop and lesion size weakened as the saline‐pool LI became higher (e.g., 120 Ω group (r2 = .30, r2 = .18, and r2 = .16, respectively for 120, 160, and 200 Ω), but the usage of %LI‐drop (= absolute LI‐drop/initial LI) instead of absolute LI‐drop may minimize this effect.

Conclusions

In an experimental model, baseline saline‐pool impedance significantly affects the lesion metrics and the risk of steam pops.
Efficacy and durability of posterior wall isolation with ethanol infusion into the vein of Marshall
Authors: Ishimura Masayuki , Yamamoto Masashi , Himi Toshiharu , Kobayashi Yoshio
Published: June 2023

Introduction

Ethanol infusion into the vein of Marshall (EIVOM) is expected to be an adjunctive therapy for mitral isthmus (MI) ablation. Additionally, EIVOM can widely ablate the epicardium via the branches that extend to the left atrial posterior wall (LAPW) and facilitate LAPW isolation. This study aimed to investigate the efficacy and durability of LAPW isolation with EIVOM.

Methods

Our cohort consisted of 413 patients with atrial fibrillation (AF) who underwent both LAPW and MI ablations. EIVOM was first attempted in 177 (35%) patients with adequate VOMs. The VOM was infused with 5 mL of ethanol with a double coaxial guiding catheter technique. Both ablations were performed only by radiofrequency ablation (the RF group) in the remaining 236 (57%) patients.

Results

EIVOM with 5 mL of ethanol was completely achieved in 106 patients (the EIVOM group). The application duration of LAPW isolation did not differ significantly between the two groups (718 ± 276 vs. 709 ± 288 s; p = .78). LAPW debulking ablation was required in 64/106 (60%) and 176/236 (75%) patients in the EIVOM and RF groups, respectively (p < .05). However, AF‐ or atrial tachycardia‐free survival analyses revealed no significant differences between the two groups (log‐rank p = .70). Among the cases of recurrence, 17 and 38 patients underwent subsequent ablation sessions; LAPW was reconnected in 9/17 (53%) and 25/38 (53%) patients (p = .36) in the EIVOM and RF groups, respectively.

Conclusion

EIVOM reduced the number of cases that required LAPW debulking ablation but did not improve the durability of LAPW isolation or clinical outcomes.
Type 1 interferon signature and cytotoxic T lymphocyte activation targeted against sweat ducts in inflammatory acquired idiopathic generalized anhidrosis
Authors: Sano K. , Asahina M. , Araki N. , Uehara T. , Iwaya M. , Okuyama R.
Published: June 2023

Background

Acquired idiopathic generalized anhidrosis (AIGA) leads to heat intolerance due to the loss or reduction in thermoregulatory sweating over an extensive area of the body. The pathomechanism of AIGA is still unclear but is believed to be autoimmune.

Objectives

We investigated the clinical and pathological features of inflammatory AIGA (InfAIGA) and noninflammatory AIGA (non‐InfAIGA) within the skin.

Methods

We compared anhidrotic and normohidrotic skin samples from 30 patients with InfAIGA and non‐InfAIGA, as well as skin samples of melanocytic nevus as a negative control. We conducted morphometric analysis and immunohistochemical analysis of cell types and expression of inflammatory molecules (TIA1, CXCR3 and MxA). MxA expression was used as a proxy for type 1 interferon activity.

Results

We found that tissue samples from patients with InfAIGA exhibited inflammation within the sweat duct and atrophy of the sweat coil, whereas patients with non‐InfAIGA exhibited only atrophy of the sweat coil. Cytotoxic T lymphocyte infiltration and MxA expression were only observed in the sweat ducts of patients with InfAIGA.

Conclusions

InfAIGA is associated with increased sweat duct inflammation and sweat coil atrophy, whereas non‐InfAIGA is only associated with sweat coil atrophy. These data suggest that inflammation leads to epithelial destruction of sweat ducts associated with the sweat coil atrophy and subsequent loss of function. Non‐InfAIGA may be regarded as a postinflammatory state of InfAIGA. These observations indicate the contribution of both type 1 and type 2 interferons to sweat gland injury. The mechanism involved is similar to the pathomechanism of alopecia areata (AA).
Tainted Legacies and the Journal of Religious Ethics
Authors: Guth Karen V.
Published: June 2023

This essay reflects on the role academic journals like the JRE can play in facilitating and addressing tainted legacies. As an institution in religious ethics, the journal not only determines whose work is important, but it also replicates such judgments, passing certain sets of issues, concerns, and methods down from the past to the present, shaping future work. Journals highlight the systemic, structural elements of legacies that we often neglect in heated debate over how to respond to them. Consequently, they illuminate the complexity of the problems tainted legacies present. I first discuss three ways a journal like the JRE facilitates the structural features of tainted legacies in religious ethics. I then suggest how the JRE might implement a position I call the “reformer” in response to such legacies. This position emphasizes practices of moral repair designed to challenge the systemic injustices that underlay tainted legacies.
Effect and mechanism of fluctuant glucose on restraining implant osseointegration in diabetes
Authors: Song Dawei , Wang Chenchen , Liang Jin , Jia Tingting
Published: June 2023

Objectives

The objectives of the study was to discuss the effect and mechanism of fluctuant glucose (FG) on implant osseointegration in type 2 diabetic mellitus (T2DM).

Materials and Methods

Rats were divided into control, T2DM and FG group, and the implants were inserted into their femurs. Micro‐CT and histological analysis were used to evaluate the effect on osseointegration in vivo. And we investigated the effect of different conditions (normal, control, high glucose, and FG medium) on rat osteoblast in vitro. Then transmission electron microscope (TEM) and Western blot were used to evaluate the endoplasmic reticulum stress (ERS) response. Finally, 4‐PBA, an inhibitor of ERS, was added into different conditions to observe the functions of osteoblast.

Results

In vivo, Micro‐CT and histological analysis showed that the percentage of osseointegration in FG rats were lower than other two group. In vitro, the results demonstrated that the adhesion of the cells becomes worst, and osteogenic ability was also severely impaired in FG group. In addition, FG could induce more serious ERS and 4‐PBA could improve the dysfunction of osteoblasts induced by FG.

Conclusion

Fluctuant glucose could restrain the implant osseointegration in T2DM, and the effect was more obvious than consistent high glucose by a possible mechanism of activation ERS pathway.
Tongue metastasis of malignant melanoma: A case report and a systemic review of the literature
Authors: Sääksjärvi Iiris , Degerholm Sara , Ahde Hanna , Salo Tuula , Mauramo Matti
Published: June 2023

Objectives

The incidence of malignant melanoma, with potential for tongue metastasis, is increasing. This study presents a case of tongue metastasis of cutaneous malignant melanoma, along with a comprehensive systematic review of the cases presented in English literature. The aim is to increase clinical and pathological knowledge of these challenging cases.

Materials and Methods

The literature search was carried out according to PRISMA guidelines by two independent researchers using four online databases: Medline, PubMed, Web of Science and Scopus.

Results

Altogether 24 cases of tongue metastasis of malignant melanoma were observed (mean age 54.9 years, range 27–86 years). The average time from the primary tumour to tongue metastasis was 4.5 years. The metastatic tumour was generally indolent or mildly symptomatic. The most prevalent clinical presentation was a submucosal, non‐ulcerated tumour mass, located in the tongue base or lateral surfaces. The prognosis at the time of tongue metastasis was generally poor, with a mean survival of 2.9 months.

Conclusion

Considering the mild symptoms, varying age of the subjects and interval from the initial diagnosis, a comprehensive anamnesis and regular oral examination should be emphasized, and metastatic malignant melanoma considered in cases of lingual tumour.
Evaluation of salivary Thy‐1 in health, periodontitis, and obesity
Authors: Al‐Ameri Hawra’a Wisam , Shetty Sunaina , Rahman Betul , Gopalakrishnan Aghila Rani Koippallil , Ismail Asmaa Anwer , Acharya Anirudh B.
Published: June 2023

Objectives

Thy‐1 (CD90) is a glycosylphosphatidyl‐anchored protein belonging to the immunoglobulin family and is known to control mesenchymal stromal cells differentiation into osteoblasts or adipocytes. The study aimed to investigate the salivary levels of Thy‐1 in health, periodontitis, obesity, and any potential association.

Materials and Methods

Seventy‐one participants were divided into four groups: healthy (H), subjects with periodontitis (P), obese individuals (O), and obese individuals having periodontitis (PO). Unstimulated whole saliva was collected from participants who were evaluated for periodontal parameters. The levels of Thy‐1 were measured with a commercially available ELISA kit. The data were statistically analyzed.

Results

A significant difference in salivary Thy‐1 levels among different groups was observed. Periodontitis patients had the maximum, and obese individuals had the minimum Thy‐1 levels. Significant differences between H and P, H and PO, P and O, and O and PO were observed. Overall correlations between Thy‐1 and periodontal parameters and a positive correlation with pocket depth in group PO were noted.

Conclusion

Thy‐1 could be detected in the saliva of all study participants. It is implied that a local inflammatory condition like periodontitis elevates the salivary levels of Thy‐1 with, and without obesity.
PEGGY PIGGOTT: WOMEN AND BRITISH ARCHAEOLOGY (1930–1945)
Authors: Pope Rachel , Davies Mairi H.
Published: June 2023

The 2021 film, The Dig, stimulated much interest in discovering more about Peggy Piggott, the archaeologist who first ‘struck gold’ at Sutton Hoo. Piggott was a leading British prehistorian, who produced over sixty published works for the field. Here we examine her early life and career, her training with the Curwens and the Wheelers, her marriage to Stuart Piggott, and her recognized expertise that led to her joining the Sutton Hoo team in 1939. During WWII, she established the modern standard for barrow excavation, and in 1944 was recognized by the Society of Antiquaries for her ‘devotion to the study of archaeology’. Piggott provides a lens through which we consider the careers of 1930s women archaeologists – those factors enabling access to archaeology (class, wartime opportunity) and factors that limited progress (lack of a degree, marriage).
Some anecdotes about Wittgenstein
Authors: O'Hara Neil
Published: June 2023

This brief notice records anecdotes about Wittgenstein gathered from Br. Herbert Kaden OSB.
Rational risk‐aversion: Good things come to those who weight
Authors: Bottomley Christopher , Williamson Timothy Luke
Published: June 2023

No existing normative decision theory adequately handles risk. Expected Utility Theory is overly restrictive in prohibiting a range of reasonable preferences. And theories designed to accommodate such preferences (for example, Buchak's (2013) Risk‐Weighted Expected Utility Theory) violate the Betweenness axiom, which requires that you are indifferent to randomizing over two options between which you are already indifferent. Betweenness has been overlooked by philosophers, and we argue that it is a compelling normative constraint. Furthermore, neither Expected nor Risk‐Weighted Expected Utility Theory allow for stakes‐sensitive risk‐attitudes—they require that risk matters in the same way whether you are gambling for loose change or millions of dollars. We provide a novel normative interpretation of Weighted‐Linear Utility Theory that solves all of these problems.
Evidence‐based policies: Lessons from regulatory science
Authors: Luján José Luis
Published: June 2023

In this article, various examples of controversies in regulatory science are analyzed concerning chemical and pharmaceutical products and functional foods. In these controversies, it is possible to show the relationship between epistemic policies and regulatory objectives (decision‐making objectives). From an analysis of this relationship, four points must be noted that can be extrapolated to current evidence‐based policy proposals: (1) The regulatory objectives determine the evidence hierarchies. (2) Evidence hierarchies determine the appropriate scientific methodology and, by extension, the scientific knowledge that will be generated. (3) The use of scientific knowledge in the formulation of public policies is an example of extrapolation, and such cases should be viewed as hypotheses whose testing requires evidence from different lines of research. (4) The suitability of a particular evidentiary hierarchy depends on what is at stake; that is, on an assessment of the gains and losses to which the policy or regulation based on such an evidentiary requirement may lead.

Related Articles

Nunes Silva, Carlos. 2012. “Policy and Evidence in a Partisan Age: The Great Disconnect—By Paul Gary Wyckoff.” Politics & Policy 40(3): 541–43. https://doi.org/10.1111/j.1747‐1346.2012.00363.x.

Sinclair, Thomas A. P. 2006. “Previewing Policy Sciences: Multiple Lenses and Segmented Visions.” Politics & Policy 34(3): 481–504. https://doi.org/10.1111/j.1747‐1346.2006.00025.x.

Smith‐Walter, Aaron, Holly L. Peterson, Michael D. Jones, and Ashley Nicole Reynolds Marshall. 2016. “Gun Stories: How Evidence Shapes Firearm Policy in the United States.” Politics & Policy 44(6): 1053–88. https://doi.org/10.1111/polp.12187.

Lemire, Sebastian, Laura R. Peck and Allan Porowski. 2023. “The Evolution of Systematic Evidence Reviews: Past and Future Developments and Their Implications For Policy Analysis.” Politics & Policy 00(0): 1–24. https://doi.org/10.1111/polp.12532.
Find your match! How emerging economy firms combine different forms of openness to innovate
Authors: Ozturk‐Kose Ebru , Mayer Michael , Stadler Christian
Published: June 2023

This study investigates how combining different forms of formal collaboration (i.e., developed vs. emerging economy collaborations) and informal search (i.e., search breadth vs. depth) affects the innovation performance of emerging economy firms. The open innovation literature has primarily focused on the effect of individual open innovation practices, generating conflicting results. We argue that outcomes depend on specific combinations of open innovation practices. Drawing on the notion of external absorptive capacity routines, we argue that combining forms of openness that rely on the same absorptive capacity routine positively affects innovation performance. We specifically ask whether broad or deep search, which rely on different routines, is more appropriate for emerging economy firms who are collaborating with developed or other emerging economy partners. We test our hypotheses using responses from 659 manufacturing and service firms to two waves of the Turkish Innovation Survey. Using Tobit regression analysis, we generate findings consistent with our expectations. We find that deep search is appropriate when collaborating with developed economy partners, whereas broad search is appropriate when collaborating with other emerging economy partners. These confirm the importance of combining forms of openness with matching routines. Overall, we illustrate the importance of finding the right combination of different forms of openness.
Material and nonmaterial impacts of theCOVID‐19 pandemic: Evidence from a low‐income country
Authors: Lohmann Rebecca , Hoffmann Lisa
Published: June 2023

How have COVID‐19‐related restrictions affected consumption levels and life satisfaction in low‐income countries? We conducted phone surveys with 577 households in Liberia to compare consumption patterns across three points in time: November 2019 (pre‐COVID‐19), May 2020 (short term), and September 2020 (medium term). This article analyzes the impacts of the Covid‐19 pandemic and the related restrictions on food and nonfood consumption, which we categorize as “material” welfare and life satisfaction, which we categorize as “nonmaterial” welfare. We find differences between food and nonfood consumption patterns under pandemic conditions. In particular, consumption by households dependent on food and labor markets was negatively affected by the pandemic. In terms of life satisfaction, we find that most respondents perceived their lives to have worsened due to the pandemic.
Shifts in carbon partitioning by photosynthetic activity increase terpenoid synthesis in glandular trichomes
Authors: Saadat Nima P. , van Aalst Marvin , Brand Alejandro , Ebenhöh Oliver , Tissier Alain , Matuszyńska Anna B.
Published: June 2023

Several commercially important secondary metabolites are produced and accumulated in high amounts by glandular trichomes, giving the prospect of using them as metabolic cell factories. Due to extremely high metabolic fluxes through glandular trichomes, previous research focused on how such flows are achieved. The question regarding their bioenergetics became even more interesting with the discovery of photosynthetic activity in some glandular trichomes. Despite recent advances, how primary metabolism contributes to the high metabolic fluxes in glandular trichomes is still not fully elucidated. Using computational methods and available multi‐omics data, we first developed a quantitative framework to investigate the possible role of photosynthetic energy supply in terpenoid production and next tested experimentally the simulation‐driven hypothesis. With this work, we provide the first reconstruction of specialised metabolism in Type‐VI photosynthetic glandular trichomes of Solanum lycopersicum. Our model predicted that increasing light intensities results in a shift of carbon partitioning from catabolic to anabolic reactions driven by the energy availability of the cell. Moreover, we show the benefit of shifting between isoprenoid pathways under different light regimes, leading to a production of different classes of terpenes. Our computational predictions were confirmed in vivo, demonstrating a significant increase in production of monoterpenoids while the sesquiterpenes remained unchanged under higher light intensities. The outcomes of this research provide quantitative measures to assess the beneficial role of chloroplast in glandular trichomes for enhanced production of secondary metabolites and can guide the design of new experiments that aim at modulating terpenoid production.
A new species of Homonota (Squamata: Phyllodactylidae) from the Uruguayan Savanna
Authors: Malleret Matías M. , Pisetta Nádia F. , Fagundes Nelson J. R. , Verrastro Laura V.
Published: June 2023

Cryptic diversity is frequent among lizards from the Neotropical region. In particular, geckos belonging to the genus Homonota exhibit high levels of phenotypic and ecological conservatism. Homonota uruguayensis is endemic to rocky outcrops in the Uruguayan Savanna, and a previous study based on mitochondrial DNA (mtDNA) revealed a highly divergent clade in an isolated population. In this study, we used a set of two mitochondrial (Cytb and 12S) and six autosomal (DMLX, MXRA, PRLR, SNCAIP, H19B and H30B) genetic markers to evaluate the taxonomic status of different populations of H. uruguayensis. We then used morphological data to further check the favoured coalescent model of species delimitation. A careful re‐evaluation of meristic and continuous morphological traits within the H. uruguayensis complex indicated that the new species can be morphologically distinguished. The species tree confirmed the deep divergence times associated with the new species previously reported for mtDNA and indicated congruence among independent gene trees. Overall, the results clearly support the recognition of a new species, based on deep genetic divergence and morphological differentiation. While the full geographic range of the new species has not been thoroughly characterized, the localized endemism in a patch of rocky outcrops surrounded by intense silviculture activity strongly suggest that the new species should be considered to be under some degree of threat.
Weight filtrations on Selmer schemes and the effective Chabauty–Kim method
Authors: Betts L. Alexander
Published: June 2023

We develop an effective version of the Chabauty–Kim method which gives explicit upper bounds on the number of$S$-integral points on a hyperbolic curve in terms of dimensions of certain Bloch–Kato Selmer groups. Using this, we give a new ‘motivic’ proof that the number of solutions to the$S$-unit equation is bounded uniformly in terms of$\#S$.
Condition Monitoring of Wind Turbines Based on Anomaly Detection Using Deep Support Vector Data Description
Authors: Peng Dandan , Liu Chenyu , Desmet Wim , Gryllias Konstantinos
Published: June 2023

Wind turbine condition monitoring is considered a key task in the wind power industry. A plethora of methodologies based on machine learning have been proposed for monitoring wind turbines, but the absence of faulty data at the amount and the variety needed still set limitations. Therefore, anomaly detection (AD) methodologies are proposed as alternatives for fault detection. Deep learning tools have been introduced in the research field of wind turbine monitoring for the purpose of higher detection accuracy. In this work, a deep learning-based anomaly detection method, the deep support vector data description (deep SVDD), is proposed for the monitoring of wind turbines. Compared to the classic SVDD anomaly detection approach, this method combines a deep network, more specifically, a convolutional neural network, with the SVDD detector in order to automatically extract effective features. To test and validate the effectiveness of the proposed method, we apply the deep SVDD method to supervisory control and data Acquisition data from a real wind turbine use case, targeting the ice detection on wind turbine blades. The experimental results show that the method can effectively detect the generation of ice on wind turbines' blades with a successful detection rate of 91.45%.
Dose Rate Assessment Around the PCFV Release Line During Severe Accident Conditions in Nuclear Power Plant Krsko
Authors: Grgic Davor , Duckic Paulina , Bencik Vesna , Sadek Sinisa
Published: June 2023

Passive containment filtered vent (PCFV) was installed in Nuclear Power Plant Krsko (NEK) in 2013 as part of the safety upgrade program. It is intended for severe accident consequences prevention and mitigation by ensuring the containment integrity. When the pressure in the containment reaches limiting value, containment atmosphere is released into the environment through the PCFV system exhaust line. But, before release in the environment, the containment atmosphere passes through five aerosol filters in the containment and one iodine filter in the auxiliary building (AB) to reduce isotopic activity. In this paper, dose rates around the exhaust line of the PCFV system resulting from radioactivity release in case of a severe accident were determined in a four-step methodology. The assumed severe accident scenario is a beyond design basis accident station blackout (SBO) in NEK, which was simulated using the MELCOR code. Its results were input for the radionuclide transport and removal and dose estimation (RADTRAD) radiological calculations to obtain the activities released in the containment. These activities were then transformed into the gamma source intensity and spectrum using the ORIGEN-S libraries. This form of the source term is required for Monte Carlo calculations which were performed using the MCNP6.2. Two Monte Carlo calculations were performed. One for which the radiation source was modeled to emanate from the containment atmosphere and the other from the PCFV duct fluid. The main reason for the calculation was to assess limiting dose rates around PCFV duct (radiation monitor location) during actuation after severe accident. That is why the model is simple and conservative. The other task was to demonstrate that this location is not suitable for longer personnel presence in case of equipment failure during the PCFV actuation. Due to conservative assumptions, predicted dose rates are the highest expected at that location for any severe accident scenario.
Section VIII: Division 2–Alternative Rules
Authors: Osage David A. , Rodery Clay D. , Pastor Thomas P. , Brown Robert G. , Henry Philip A. , Sowinski James C.
Published: June 2023

This chapter covers alternative rules to the construction of pressure vessels under Section VIII, Division 2. The Section is made up of nine parts and the organization within each part is as follows: rules and requirements, nomenclature, tables, figures, normative annexes, and informative annexes. Part 1 contains general requirements addressing the following subjects: reference standards, units of measurement, tolerances, and technical inquiries. Part 2 consolidates the responsibilities and duties of the User, Manufacturer, and Authorized Inspector. It also contains general requirements for report forms and maintenance of records. Part 3 contains all requirements related to materials of construction and is organized in a similar fashion to Part AM of VIII-2. The coverage includes materials permitted for construction of vessel parts, and supplemental requirements for ferrous materials, Cr–Mo steels, Q and T steels with enhanced tensile properties, nonferrous metals, and boltings and castings. The requirements of Part 4 provide design rules for commonly used pressure vessel shapes under pressure loading and, within specified limits, rules or guidance for treatment of other loadings. Design requirements for the application of the design-by-analysis methodology in VIII-2 are described in Part 5. Detailed design procedures utilizing the results from a stress analysis are provided to evaluate components for plastic collapse, local failure, buckling, and cyclic loading. Part 6 consolidates the various fabrication requirements from old VIII-2 and VIII-1. Part 7 contains the requirements for examination during construction of pressure vessels. Part 7A covers the responsibilities and duties for inspection and examination during construction of pressure vessels. Part 8, which contains the rules pertaining to the pressure testing of the vessel following completion of fabrication, describes requirements for hydrostatic testing and pneumatic testing. The requirements for overpressure protection of vessels built in accordance with this VIII-2 are provided in Part 9.
Section XI: Rules for Inservice Inspection and Tests of Nuclear Power Plant Components
Authors: Swayne Richard W.
Published: June 2023

This chapter discusses the general requirements of Section XI of the ASME Boiler and Pressure Vessel Code that are applicable to all Code Classes of components. It also analyzes controversial issues and topics including the applicability of the United States Nuclear Regulatory Commission Generic Letters and Information Notices.

History

The fifth and sixth editions were updated by Rick W. Swayne
Applications of Elastic-Plastic Fracture Mechanics in Section XI, ASME Code Evaluations
Authors: Mehta Hardayal S.
Published: June 2023

The role of fracture mechanics in ASME Section XI applications comes in the form of evaluation of indications or flaws detected during inservice inspection of nuclear components. The need to include the influence of significant plastic deformation, which may accompany crack initiation and the subsequent stable growth, has been the main driving force for the development of the field of elastic-plastic fracture mechanics (EPFM). This chapter traces the history of development of the EPFM from the 1960s and reviews the EPFM applications in Section XI Code. It discusses the three approaches considered in the application of EPFM in flaw evaluations: J-integral tearing modulus-based approach or J-T methodology, deformation plasticity failure assessment diagram (DPFAD) methodology, and R-6 methodology. The engineering estimation of the applied J integral is described, followed by a discussion on the application of the J-T approach in the evaluation of flaws in austenitic stainless steel piping and ASME Class 1 ferritic piping. The chapter describes the application of EPFM to reactor pressure vessel evaluation in three distinct ways: upper-shelf energy evaluation, Section XI flaw evaluation approach, and a probabilistic approach. It also explains the application of the Master Fracture Toughness Curve method to evaluate pressure vessel steels based on EPFM. The current activity within the ASME Section XI Code Groups related to the potential revision of ASME Code Case N-830 is finally summarized.
Hydrogen Piping and Pipe Lines
Authors: Meyer Jimmy E.
Published: June 2023

The ASME B31.12 Code covers piping in gaseous and liquid hydrogen service and pipelines in gaseous hydrogen service. This chapter is based on the 2014 edition of B31.12, which includes three major Parts: General Requirements (GR), Industrial Piping (IP), and Pipelines (PL). It also covers Mandatory Appendices I through XI and Nonmandatory Appendices A through F. After a brief background and coverage of the scope, intent, and organization of the Code, the chapter examines Part GR, which covers selection of materials to resist deterioration in hydrogen service. It lists the common requirements for welding, brazing, heat treating, forming and testing of welded and brazed joints, qualification of the welding and brazing procedures, and qualification of the welders and brazers to those procedures. Part GR provides information on inspection, examination, and testing along with operating and maintenance procedures that affect the safety of hydrogen transmission and distribution facilities. It also provides requirements for the development of Quality System Programs. Part IP includes requirements for materials and components, design, fabrication, assembly, erection, inspection, examination, testing, operation, and maintenance of piping, and applies to piping for liquid and gaseous hydrogen and joints connecting piping to equipment. It describes four basic methods for design of components for internal pressure and lists the dimensional standards for piping components. Part PL sets forth the requirements for materials, components, design, fabrication, assembly, erection, inspection, examination, testing, operation, and maintenance of hydrogen pipelines.

History

Jimmy E. Meyer revised the initial inputs of Louis E. Hayden who authored this chapter for the fourth edition. The current online edition has been reviewed by George Rawls and updated by Jimmy E. Meyer.
History, Philosophy, & Background of Section III, & Development of ASME Code Rules for Nuclear Vessels
Authors: Rao K. R.
Published: June 2023

The rules for the construction of Section III are based on the design and construction rules in Section VIII of the ASME Boiler and Pressure Vessel Code. This chapter identifies that the ASME Section III Nuclear Code is completely compatible with Sections I and VIII. Before the Nuclear Code was published, Code Cases for Sections I and VIII were written for the first nuclear plants in the early 1950s. In 1959, the Code Case book addressed nuclear installations as follows: General Requirements for Nuclear Vessels 1270N; Safety Devices 1271N; Containment and Intermediate Containment Vessels 1272N; Nuclear Reactor Vessels and Primary Vessels 1273N; and Special Material Requirements 1274N. The explanations of these original Code Cases are given in the chapter. The chapter briefly discusses the three types of pressure vessels addressed in Section III, namely, N-131 Class A Vessels, N-132 Class B Vessels, and N-133 Class C Vessels, covering the aspects of design, materials, and inspection, among others. It presents a brief note on the changes made to Section III in the 1971 edition. The chapter also presents an appendix providing information on the five Code Cases in the form of inquiries and replies. It covers the original Commentaries for Section III and Section VIII, Division 2, which is based on Section III reactor pressure vessel rules with the same design factor 3.