bluuebunny/crossref_metadata_2025 huggingface dataset:
Pyranocycloartobiloxanthone a Suppressed Metastasis Ovarian Cancer Cells Via S Phase Cell Cycle Arrest and Apoptosis
Authors: Abd Rahman Mashitoh , Mohd Hashim Najihah , Ahmed Idris Adewale
Published: January 2024

Ovarian cancer is a deadly disease with a poor prognosis, highlighting the urgent need for novel therapeutic alternatives. Pyranocycloartobiloxanthone A (PA), an exceptional xanthone compound has garnered attention due to its diverse medicinal properties. This study aimed to investigate the anticancer properties of PA on metastatic ovarian cancer SKOV-3 cells. Cytotoxicity was evaluated using an MTT assay, while apoptotic mechanisms were determined using AO/PI double staining, annexin V-fluorescein isothiocyanate, multiple cytotoxicity-3, reactive oxygen species (ROS) production, caspases, real-time PCR, western blot, human apoptosis protein profile array and cell cycle analysis. PA inhibited SKOV-3 cell proliferation in a time-dependent manner, with an IC50 of 7.0 ± 0.5 µg/mL and a selectivity index of 13.2 after 72 h of treatment. PA induced apoptosis through the intrinsic apoptotic pathway and arrested the cell cycle at the S phase. PA stimulated ROS production and disrupted the mitochondrial membrane potential, releasing cytochrome c from mitochondria to the cytosol. Additionally, results from human apoptotic protein profile indicated that 21 proteins were upregulated while 22 proteins were downregulated, including Bcl-2, survivin, and HSP70. These findings suggest that PA has the potential as a lead molecule in the development of a chemotherapy drug for ovarian cancer. However, further research is necessary to evaluate the safety and efficacy of PA in preclinical and clinical settings.
A Coral-Like Mo2C/TiO2 Photoelectrode for Photoelectrochemical Water Splitting
Authors: Moridon Siti Nurul Falaein , Arifin Khuzaimah , Jeffery Minggu Lorna , Mohamed Mohamad Azuwa , Muslimin Masliana , Zaini Ahmad Zaki , Kassim Mohammad B.
Published: January 2024

Titanium dioxide (TiO2) is one of the most explored photoelectrode materials of water splitting for hydrogen generation. However, TiO2 has a bandgap of 3.2 eV, which restricts its energy absorption to UV light, and the photoexcited electrons and holes swiftly recombine. Thus, alteration of the band structure, such as by adding materials as cocatalysts, is needed. 2D molybdenum carbide (Mo2C) has been researched extensively as an excellent non-noble cocatalyst owing to its Pt-like H+ adsorption capacity and high conductivity. In this work, composites of TiO2 and Mo2C with four different compositions were produced using the sol-gel method, and their photoelectrochemical activity for water splitting was assessed. The composites were spin-coated onto FTO conducting glass, and FESEM analysis indicated that TiO2 nanoparticles are widely disseminated across Mo2C to form coral-like structures. Analysis via X-ray diffraction verified the existence of peaks composed of TiO2 and Mo2C. The sample containing 3% Mo2C had the greatest increase in photocurrent density, which was approximately 1.56 mA cm-2 at a potential of 1.0 V against Ag/AgCl (1.59 vs. RHE), which is five times that of bare TiO2. In addition, the composite's onset potential moved to a lower potential. Our findings suggest that adding Mo2C increases the photoelectrochemical performance of the TiO2 photoelectrode. This work indicates the feasibility of employing Mo2C as a cocatalyst to improve the performance of TiO2 for photoelectrochemical H2 production.
The Geometrical Properties of Round Bamboo of Gigantochloa levis and their Effects on Construction Design
Authors: Abdul Wahab Mohd Jamil , F.K. Naysir Nor Marzuina
Published: January 2024

Round bamboo is reviewed as a highly potential material for building components. However, the assessable data of the geometrical variability of Malaysian bamboos proposed as structural members are greatly lacking. A study was conducted to establish the geometric properties of Gigantochloa levis culms and to derive the important parameters that will affect engineering design. The evaluations were based on the internode length, culm diameter, wall thickness, and the second moment of area with respect to the height of the culm. Most internode sections measured between 35 and 50 cm. An internodal crack could severely change the cross-sectional geometry of the culm. Two major factors concerning culm diameter that need to be considered in the design are diameter shrinkage and taper rate. The diameter of a culm was fairly equal within the height of 1 to 5 m and decreased from 5 m onwards. Upon drying, the culm of the larger diameter tended to shrink more than the smaller one. Thickness irregularity around the circumference of the internode wall was minor. The shrinkage of the internode wall was within 20%. The selection of culms for construction is best between the height of 1 and 5 m whereby the internodal length is more consistent.
Estimation of Population Size Based on One-Inflated, Zero-Truncated Count Distribution with Covariate Information
Authors: Jongsomjit Tita , Lerdsuwansri Rattana
Published: January 2024

In order to estimate the unknown size of the population that is difficult or hidden to enumerate, the capture-recapture method is widely used for this purpose. We propose the one-inflated, zero-truncated geometric (OIZTG) model to deal with three important characteristics of some capture–recapture data: zero-truncation, one-inflation, and observed heterogeneity. The OIZTG model is generated by two distinct processes, one from a zero-truncated geometric (ZTG) process, and the other one-count producing process. To explain heterogeneity at an individual level, the OIZTG model provides a simple way to link the covariate information. The new estimator was proposed based on the OIZTG distributions through the modified Horvitz-Thomson approach, and the parameters of the OIZTG distributions are estimated by using a maximum likelihood estimator (MLE). With regard to making inferences about the unknown size of the population, confidence interval estimations are proposed where variance estimate of population size estimator is achieved by using conditional expectation technique. All of these are assessed through simulation studies. The real data sets are provided for understanding the methodologies.
Post-Truth Çağda Post-Reality Sanat Deneyimi: Metaverse Konseri Örneği
Authors: ÇELİK Fikriye
Published: January 2024

Fiziki mekâna dijital sanallığı iliştirerek gerçeklik sonrası evreni inşa eden metaverse, kalıcı ve sürekli çok kullanıcılı bir ortam yaratmıştır. Metaverse kavramı; sanal ortamlar, dijital nesneler ve insanları bir araya getirip gerçek olanın temsilcisiyle yapay olanın parçası arasında etkileşimi sağlayan AR ve VR teknolojilerinin yakınsamasını açıklamaktadır. Gerçek hayat deneyimlerini “büyük evren”e uyarlama çabası ortaya koyan yeni teknolojilerin iletişim merkezli bu son uyarlaması, “büyük takas”ın varlığını delillendirmektedir. Atası çizgi romana dayanıp yakınsamadan doğan kesin uzaksamanın örneği olarak karşımızda duran metaversal davranış ya da katılımların bugün başta dijital oyun dünyası olmak üzere pek çok biçimine rastlanmaktadır. Canlı konser deneyimi de bunlardan biridir. Yarı yapılandırılmış görüşme tekniğinden yararlanılan bu çalışmada Epic games’in Fortnite oyununda gerçekleşip dünyanın en yüksek katılımlı ilk metaverse konseri olma unvanını elinde bulunduran Travis Scott konserine katılan 10 kişiye ulaşılmıştır. Kasım-Aralık 2022’de gerçekleştirilen mülakatlar niteliksel içerik analizi tekniğiyle çözümlenmiştir. Elde edilen bulgular metaversal davranışın nedenselleştirilmesinde; üst teknik ve teknoloji beklentisi, zenginleştirilmiş hipergerçek hayali, gündelik hayatta olanaksız görünen eylemleri deneyimleme isteği, yeni dünyanın sunduğu fırsatlardan yararlanma ihtiyacı gibi gerekçeleri işaret etmektedir. Araştırma sonunda çevrimiçi düşünsel ve eylemsel pratiğin sergilendiği bu yeni evren hakkında yürütülecek vaka analizlerine ve katımcıların bireysel deneyimlerini önceleyen çalışmalara ihtiyaç olduğu anlaşılmıştır.
Youtube'da Çocuk Emeği: İzleyici Çocuklar Perspektifinden Nitel Bir Araştırma
Authors: CINGI Yasemin , KÖSEDAĞ Mehmet Sena
Published: January 2024

Sosyal medya, internet tabanlı platformlar aracılığıyla kullanıcıların içerik oluşturduğu, paylaştığı, etkileşimde bulunduğu dijital bir iletişim aracı olarak günümüzde yaygın bir şekilde kullanılmaktadır. Sosyal medya platformları bireylerin hayatlarına yeni dijital alışkanlıklar kazandırırken, çocuklar da dönüşen bu dünyanın aktif katılımcıları olarak farklı dijital beceriler edinmektedir. Bu becerilerden birini sosyal medya platformu olan YouTube’da içerik üreterek üretilen içeriklerin yayınlanması oluşturmaktadır. Yayınlanan bu içerikler bazı çocuklar için kazanca dönüşmektedir. Böylelikle alışılan çocuk işçi kavramından farklı olarak teknolojiyle desteklenen ve çocuğun dijital emeğini içeren yepyeni bir iş alanı karşımıza çıkmaktadır. Burada temel hareket noktası, geleneksel çocuk işçiliği veya çocuk emeğinin dijitalleşmesidir. Bu bağlamda bu çalışma, YouTuber çocukların, onları izleyen çocuklar nezdinde nasıl anlamlandırıldığını, onların esasında birer çocuk işçi olduklarının farkında olup olmadığını anlamayı amaçlamaktadır. Yapılan çalışmalar incelendiğinde dijital çocuk emeğinin direkt izleyici çocuklar tarafından anlaşılmasına yönelik çalışmaların eksikliği fark edilmiş ve bu yönüyle araştırmanın literatüre katkı sağlayacağı düşünülmüştür. YouTube çocuk kanallarını takip eden, 5-13 yaş aralığındaki 15 çocukla derinlemesine görüşmeler gerçekleştirilmiş, görüşmeler MAXQDA veri analiz programında kodlanarak analiz edilmiştir. Katılımcı çocukların bu tür dijital aktiviteleri geleneksel anlamda bir emek veya iş faaliyeti olarak görmediği, dolayısıyla YouTuber çocukları da çocuk işçi olarak anlamlandırmadıkları, aksine onların ailecek eğlendiklerini ve bu eğlenceden para kazandıklarını düşündükleri sonucuna ulaşılmıştır.
Canvassing As A Political Communication Tool: A Study On Canvassing And Its Use By The Refah Party (RP) In Türkiye
Authors: ÇELEBİ Mustafa Burak
Published: January 2024

Canvassing has been one of the tools for political communication and propaganda. As its name indicates, canvassing means to get votes from voters by using different tools. Political parties conduct various face-to-face communication activities for voters either to encourage them to participate politically or to make them support their own political ideologies. It is believed that various academic studies have been conducted about different canvassing tools that political parties and leaders use in the USA. However, we might say that the number of studies on the effects of canvassing on voters in Turkey is few. Although, it’s not evaluated as a subject, we could say that in the early 1990s the most successful political party to use canvassing tools effectively and successfully was the Refah Partisi (RP). Devoted canvassing efforts of the volunteers of the party contributed to the accession to power of the party. This study depends on the compilation of leading studies on political communication and canvassing in the literature and it uses historical and qualitative methods.
Post-Truth Üzerine Yök Tez Veritabanında Yer Alan Lisansüstü Tezler Bağlamında Bibliyometrik Bir Analiz
Authors: ATEŞ Nur Banu
Published: January 2024

Bu makalenin amacı son yıllarda literatürde önemli bir yer edinen “post-truth” konusuyla ilgili YÖK Tez merkezinde yer alan lisansüstü çalışmaların bibliyometrik analizini yapmaktır. Bibliyometrik analiz post truth konusuyla ilgili çalışmalardaki değişimin belirlenmesinin yanı sıra konuyla ilgili yeni çalışmaların geliştirilmesinde farklı bir yaklaşım sunmaktadır. Bu kapsamda “post-truth” kavramı ile yapılan arama neticesinde 58 lisansüstü teze ulaşılmıştır. Ulaşılan tezlerde, yıl, dil, üniversite, enstitüler, anabilim dalları, danışman unvanları, akademik düzeyleri, sayfa aralıkları, anahtar kelimeler, kullanılan araştırma, veri toplama, veri analizi ve örneklem yöntemleri ve hipotezin varlığı gibi bibliyometrik özellikleri analize tabi tutulmuştur. Elde edilen çalışmalar nitel ve karma yöntemler için geliştirilmiş “MAXQDA Analytics Pro 2022” paket programı ile içerik analizine tabi tutulmuştur. 16’sı doktora, 41’i yüksek lisans ve 1’i sanatta yeterlilik tezi olarak sunulan tez çalışmalarının ilki 2018 yılında sunulmuştur. Post-truth çoğunlukla halkla ilişkiler, reklam, televizyon, sosyal medya gibi iletişim alanlarındaki tezlerde konu edilmiştir. Ayrıca incelenen tez çalışmalarında daha çok medya metinlerinden elde edilen dokümanların söylem ve içerik analizi teknikleri ile analiz edildiği bulgusuna da ulaşılmıştır.
PROPOSTA DE TECNOLOGIA EDUCATIVA PARA O CUIDADO DE CRIANÇAS E ADOLESCENTES COM TRAQUEOSTOMIA NA ATENÇÃO PRIMÁRIA: ESTUDO METODOLÓGICO
Authors: Silva Ellen Vitória da , Andrade Onelha Vieira , Silva Halbiege Léa Di Pace Quirino da , Farias Dyego Alves de , Sales Wesley Barbosa , Ramos Tomaz Renata
Published: January 2024

A Traqueostomia diz respeito a toda intervenção cirúrgica que relacione acesso a traqueia. Evidências revelam que a traqueostomia na infância apresenta maiores índices de morbidade e mortalidade em comparação a população adulta. O presente estudo tem como objetivo confeccionar uma tecnologia educativa, voltada para os familiares e cuidadores de crianças e adolescentes com traqueostomia, bem como profissionais da atenção primária. Trata-se da construção de uma tecnologia em saúde fundamentada a partir de uma revisão integrativa da literatura. A realização deste produto contemplou três etapas: etapa 1- revisão da literatura; etapa 2- seleção de conteúdo; etapa 3- elaboração do material educativo. A cartilha elaborada abordou os seguintes tópicos: I. recomendações dos tipos de cânulas, II. recomendações da fixação dos tubos, III. troca da cânula, IV. higiene do estoma, V. técnica de esterilização da cânula, VI. cuidados com aspiração e umidificação, VII. recomendações para a prevenção da decanulação acidental, VIII. informações sobre situações de emergência. Este material é direcionado aos pais, cuidadores e profissionais da atenção básica, que assistem crianças e adolescentes com traqueostomia. Tendo como próxima etapa deste trabalho, a validação do conteúdo e de aparência, para que seja considerado apto à utilização dentro da prática assistencial.
CREATIVE WORK OF LESYA UKRAЇNKA IN PERCEPTION OF ROMAN RACHMANNY
Authors:   National Pedagogical University named after M. P. Drahomanov, Kyiv, Ukraine, Pogrebennik V. F.
Published: January 2024

The article investigates the Roman Olynyk-Rachmanny’s essays and his journalist articles, dedicated to the life and creativity of Lesya Ukraїnka and Ukrainian famous writers from her generation. It is covered in logical order, how the understanding of the poetics of the writers poetry developed in accordance with their vision and perception by R. Olynyk (pen-name Roman Rachmanny, 1918–2012). The content of his articles, essays etc. reveales Lesya Ukraїnka’s individual contribution to the dynamics 123 of the system of genres, the improvement of lyrics personosphere and technical means of the literary modeling of reality, the combination of realism and romanticism in Ukrainian lyrics and drama of the end of the XIX-th – beginning of the XX-th centuries. Roman Olynyk, well-known in North America journalist and scholar (PhD Montreal University), historian and literary critic, is also considered as an ambassador of the Ukrainian culture in free Western World, who through his more than 1300 publications in Polish, English, Dutch, German, French and Norwegian languages drew attention to Ukrainian struggle for Freedom, popularized the creative achievements of the Ukrainian literary coryphaeus T. Shevchenko, I. Franko, Lesya Ukraїnka’s and others. His reasoning about Lesya Ukraїnka, V. Stefanyk, as it proved in article, is still marked by accurate definitions and symbolic assessments, interesting literary parallels, exspressed with knowledge of the case with critical remarks. The scientist righly affirmed the ascending evolution of the writer, who permanent enriched the recipients with new fruits of his socially significant talent, with represented the hole “Ukraina militans” (against tzarist Russia opression) and delved into the people’s soul. With good reason, R. Olynyk-Rachmanny emphasized her skill as an observer and psychologist, a master of sharp thoughs, and finally as intellectual-democrat, who promoted humanism, patriotism and high idealism of the Ukrainian literature’s classic heritage.
THE LYRICAL IMAGE OF THE CITY IN THE “CRIMEA MEMORIES” BY LESYA UKRAINKA
Authors:   Kyiv National University of Construction and Architecture, Kyiv, Ukraine, Prysiazhniuk Оksana M.
Published: January 2024

The article is dedicated to the prominent Ukrainian poetess of the XIX–XX time fence – Lesya Ukrainka, namely to the most interesting and fascinating period of her oeuvre – the Crimean. The poetess’s lyric poetry is analyzed from the position of a new poetic text reading. The main attention is paid to the terms “chronotopos”, “topos” as the main categories of imaginative world crystallization, to the revelation of the spatial panorama, the interpretation of the antithetic and equivalent toposes, which are used in the poetess’s lyric poetry of that period. In the poetic and artistic plan of the lyrical cycle, the topos of those southern cities where Lesya Ukrainka visited during her first trip to the Crimea are reproduced. Three of the twelve poems of the cycle are dedicated to the city of Bakhchisarai. The lyrical “I” in Lesya Ukrainka’s poems is usually associated with a topos, mostly urban, unfolds locally – here and now. The lyrical heroine of the analyzed cycle of poems thinks of herself only as a city dweller. She is intelligent, educated, spiritually rich, refined, of course, duplicates the figure of the writer. Basically, the space in Lesya Ukrainka’s poetic works is built on a realistic principle. Sometimes the writer refuses the characteristic of realism descriptiveness. Then the symbolic arrangement of space is very rich and varied. In ideological and aesthetic, culturological and intellectual terms, the artistic model of the world proposed by the poetess is not limited, although geographically determined by the local definition of the thematic framework of the lyrical cycle.
BIBLICAL ALLEGORIES OF LESYA UKRAINKA IN CONTEXT OF BIBLICAL GRAPHICS OF EPHRAIM MOSES LILIEN
Authors:   Shevchenko Institute of Literature of the National Academy of Science of Ukraine, Sylyma V. I.
Published: January 2024

A new unique edition of selected works of Lesya Ukrainka “Vze bluzko ray, Zemlya obitovana” was published in celebration of 150th anniversary from the date of her birth in Kyiv. The works on biblical topics of Lesya Ukrainka, classical author of Ukrainian literature, are tightly interconnected with the biblical illustrations of Ephraim Moses Lilien within the pages of this edition. The author analyzes herein what this interconnection may bring to the audience, which human senses, as well as historical and cultural concepts it may inspire.
Does Where We Live Matter To Oral Health?
Authors: Pattanaik Swaha , Schueths April M. , H. Lawrence Raymona , Apenteng Bettye , Dounis Georgia
Published: January 2024

Oral health is essential to overall health; however, structural obstacles influence older rural residents' oral health outcomes, especially those from disadvantaged backgrounds in the South. Poor oral health is typically attributed to individual choices, shifting the focus from the inconspicuous community influences, making it more difficult for older rural people to obtain oral healthcare. This qualitative study explores how older adults in rural Georgia understand the community's role in shaping their oral health. Twenty-two older adults were interviewed from five rural communities in southeast Georgia. Participants defined their community in geographic terms. Community barriers and self-reliance emerged as themes of how living in a rural community affects oral health. The concepts of community and one's oral health were perceived as distinct. Participants did not see how where they lived could matter to their oral health, even when they identified critical community barriers to oral health. In collaboration with rural healthcare systems, social workers can support healthy self-reliance, moving beyond a health individualism lens, by helping bolster older adults' social supports, an essential function of social relationships that positively influences a sense of community. Additionally, social workers can advocate for equitable policies to create opportunities for rural communities to support and maintain oral health.
Enhancing Competency-Based Social Work Skills Through Service Learning and Interprofessional Education in a Student-Run Free Healthcare Clinic
Authors: Simmons Christopher , Fisher Amy , McNeish Roxann , Greene Karah Y. , Thompson Melissa , Galea Jerome T.
Published: January 2024

Student-run free clinics (SRFC) offer students the opportunity to learn and work with students from other disciplines; however, there is very little research on the benefits of SRFC to social work students. The purpose of this article is to describe the qualitative student outcomes of a service learning (SL) and interprofessional education (IPE) experience in a SRFC designed to enhance the interprofessional competencies of BSW social work students. Students (n=38) enrolled in a service-learning course and participated in a semester-long SL and IPE experience at a university-affiliated interdisciplinary SRFC. Qualitative findings from student reflections indicated that students perceived that the overall experience facilitated the development of written and verbal communication skills, confidence, and professional identity. The research suggests that SL and IPE were beneficial to student development. We, therefore, recommend that other programs consider exposing BSW students to these experiences early in their program to enhance their educational experience.
Linguistics and marketing: The effect of foreign languages in advertising messages
Authors:   University of Granada, Alcántara-Pilar Juan Miguel , Sánchez-Duarte Iván Manuel ,   University of Granada, Bermúdez-Martínez María ,   University of Granada, Rodríguez-López María Eugenia ,   University of Granada
Published: January 2024

In international advertising, foreign languages often serve symbolic purposes, each associated with distinct characteristics. This study explores whether recognising the language in advertising messages influences the company's perceived image and Word-of-Mouth (WOM). We used a between-subjects experimental design to selectfive languages as independent variables: Italian, Turkish, Russian, English, and French. An audio-only advertising message for a fictional company was created and translated into these languages. Native Spanish-speaking participants listened to the message in a foreign language and responded to inquiries about the advertised firm. The findings clearly demonstrate that recognising the language significantly impactsboth company image and WOM. This underscores the nuanced role of language in shaping perceptions in international advertising. The study provides valuable insights into effective language choices for global advertising strategies, emphasising the necessity of linguistic considerations beyond mere comprehension. Recognising and leveraging the symbolic nature of languages can profoundly influence consumer perceptions and communication strategies across diverse linguistic contexts, contributing to the overall effectiveness of internationaladvertising campaigns.
Life Cycle Analysis of Dual Generator Wind Turbine System – A Case Study
Authors: C. J. Sudhakar , Joshi Diwakar. R.
Published: January 2024

There is a need to develop a turbine system that can operate at low wind speeds of 2.0 to 3.0 m/s. This will require concerted efforts to improve the design. The dual generator model can be used to extract more wind power from sites with low wind speeds, such as those found in India. In this article economic feasibility analysis of dual generator model is conducted using data obtained from the B.B.Hills wind site of Karnataka State, India. Then the economic effectiveness of the dual-generator model is compared with single generator model. Financial assessment of the both the models done by calculating net present value (NPV), benefit to cost ratio (BCR), internal rate of return (IRR) and payback period.
Association of maternal serum zinc status with neonatal birth weight
Authors: Begum Shahina , Mahmood Sharmeen
Published: January 2024

Background: Zinc, a vital micronutrient, plays a significant role in cellular growth and immune function. Insufficient maternal zinc levels can impact fetal growth, leading to low birth weight, a risk factor for neonatal morbidity and mortality. The aim of this study was to evaluate the association of maternal serum zinc status with neonatal birth weight.
Methods: This case-control study was conducted in Department of Obstetrics and Gynaecology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladeshfrom November 2019 to October 2021. A total of 60 women in their postnatal period were included in this study among which 30 women having a baby weighing < 2.5 kg were considered as the cases and 30 women having babies weighing ≥ 2.5 kg were enrolled as the controls.
Results: In the present study, none of the socio-demographic characteristics in both case and control groups were statistically significant (p > 0.05). Mean BMI was 23.88±1.36 kg/m2 in cases and 24.39±1.39 kg/m2 in controls, with 16.7% of cases overweight (p>0.05). Cases had lower maternal serum zinc (58.33±27.63 mcg/dL) than controls (82.96±16.94 mcg/dL), significantly affecting neonatal birth weight (p=0.001, r=+0.406). Low zinc levels (<68 mcg/dL) increased the risk of birth weight <2.500 Kg by nearly six times (OR 5.67, 95% CI 1.84-17.49; p=0.002).
Conclusions: From the findings, it can be concluded that serum zinc status is associated with the birth weight of the neonates. Low serum level of zinc is related to neonatal LBW.
Evaluating the management outcomes of gynaecological emergencies at a tertiary hospital, Abakaliki Southeast, Nigeria
Authors: Nwafor Amuche V. , Umeora Odidika U. , Ikeotuonye Arinze C. , Obi Vitus O. , Adiele Nnabugwu A. , Onwe Nkechinyere , Onwe Blessing I.
Published: January 2024

Background: Gynaecological emergencies are common causes of emergency hospital presentation/admission. Majority of the emergencies are mostly pregnancy related and pose threat to two lives as well as the women’s future reproductive careers. There is therefore need to evaluate them to make better preparations in managing them.
Methods: This was a 10 year (from 01 January 2012 to 31 December 2021) retrospective study of gynaecological emergencies managed at Alex Ekwueme Federal University Teaching Hospital, Abakaliki (AEFUTHA), evaluating their management and outcomes.
Results: The commonest cause of gynaecological emergency at AEFUTHA was miscarriage accounting for up to 69.1% out of which incomplete miscarriage contributed 70.8% and majority had manual vacuum aspiration with good outcome. Ruptured ectopic pregnancies were the commonest surgical emergencies with the incidence of 7.1% and all had laparotomy and partial salpingectomy. Gestational trophoblastic diseases accounted for 2.0% of gynaecological emergencies. The commonest non-pregnancy related gynaecological emergency was acute pelvic inflammatory diseases which accounted for 9.3% of cases. Other gynaecological emergencies reviewed were ovarian accidents (2.9%), abnormal uterine bleeding (3.9%), gynaecological malignancies (2.3%), coital laceration (1.5%), sexual assault (2.4%) and Bartholin’s abscess (0.2%). Factors that affected the outcome were the age of the patients, marital status and disease type and were statistically significant (p<0.05).
Conclusions: Management outcomes of gynaecological emergencies were optimum. Mortality occurred in 1.3% of cases, with gynaecological malignancies accounting for 81.4%. There is usually a good prognosis when prompt, accurate diagnosis and treatment are administered.
Colposcopic evaluation and papanicolaou smear in high risk groups and its correlation with histology
Authors: S. Sharanya , M. Shahnas , . Umadevi , Vahab Abdul
Published: January 2024

Background: Cervical cancer is one of the most common gynaecologic neoplasms. PAP smear and colposcopy are used for its early detection. This study aims to find the correlation of colposcopic evaluation with Pap smear in cervical cancer screening and with histology.
Methods: All women attending the OPD with unhealthy cervix and abnormal symptoms, who gave written informed consent were included in the study. Pap smear cytological grading, colposcopic findings were recorded. Pap smear and colposcopy findings was compared with histopathology.
Results: The study included 73 patients. Pap smear was negative in more than half of the patients (56.2%), followed by atypical squamous cells of undetermined significance in 12 (16.4%), low-grade squamous intraepithelial lesion in 17 (23.3%), high-grade squamous intraepithelial lesion in 2 (2.7%) and squamous cell carcinoma in 1 patient (1.4%).  The histopathology showed normal findings in 46 patients (63%), followed by CIN 1 in 11 (15.1%), CIN 2 in 6 patients (8.2%), CIN 3 and squamous cell carcinoma in 5 patients each (6.8%). Pap smear’s predictability of cervical malignancy showed that it had a sensitivity of 48.15, it’s specificity for identifying patients without cervical malignancy was 84.78%. Colposcopy’s predictability of cervical malignancy showed that it had a sensitivity of 88.89%, it’s specificity for identifying patients without cervical malignancy was 95.65%.
Conclusions: Colposcopy does seem to be better than Pap smear in diagnosing cervical carcinoma and also identifying patients without it.
The breastfeeding support practices, related barriers and facilitators in the neonatal intensive care unit, Uttarakhand, India
Authors: Sahota Ravi , Kaur Navpreet , Gahtori Bharti , Jain Sonam , Rastogi Ruchi
Published: January 2024

Background: Within the bustling and stressful neonatal intensive care unit (NICU) environment, implementing Baby-friendly practices presents numerous challenges. Breastfeeding initiation and duration rates among NICU infants are lower compared to healthy full-term infants. Objectives were to explore breastfeeding support practices and related barriers and facilitators in the NICU.
Methods: A retrospective study of 496 babies admitted to NICU of Sahota Superspeciality Hospital Kashipur, Uttarakhand during the time period March 2018 to February 2020 and examined maternal and infant factors. The 496 infants divided in two groups: group A: breast milk use at discharge (n=398) and group B: no breast milk use at discharge (n=98).
Results: The incidence of morbidity factors like sepsis, chronic lung disease, retinopathy of prematurity, intraventricular hemorrhage, gastrostomy tube feeds at discharge, gavage feeds at discharge noted more among the babies of group of ‘no breast milk use at discharge’ compared to other group (p<0.05). The usage of donor milk and formula milk is significantly very less in babies of group ‘breast milk use at discharge’ compared to other group (p<0.05). Duration of hospital stay was very less in the group A compare to group B (p<0.05). Respiratory distress was the most common diagnosis among the babies of group A and apnea was the most common among babies of group B.
Conclusions: Obstacles to maintaining breastfeeding in the NICU, which warrant focused efforts for enhancing practices, encompassed inadequate resources for facilitating parental involvement, impediments to expressing and providing maternal breast milk, and a notable prevalence of bottle-feeding supplemented with formula.
Uterine fibroid delivered through the cervix: diagnostic and therapeutic management about 23 cases collected at Yopougon teaching hospital, Abidjan, Côte d’Ivoire
Authors: Koffi Koffi Abdoul , Aka Kacou Edele , Toure-Ecra Ana , Brou Assane Landry , Zoua Arnold Gomez , Olou N’guessan Luc
Published: January 2024

Uterine leiomyomas or fibromyomas, more commonly known as fibroid are the most common tumours of the female reproductive tract. Sometimes a submucosal leiomyoma may become pedunculated and progressively externalize from the uterine cavity, causing increased uterine irritability, metrorrhagia and anaemia, pelvic pain and heaviness, and perception of a vaginal mass. Prevalence of this clinical form is rare. We report our experience of taking a series of twenty-three patients, which objectives was contributed to improvement of management of uterine fibroids. We reported our observation in the epidemiological, clinical and therapeutic aspects of cervical delivered forms. It took place from November 2017 to November 2021. These were housewives with an average age of 41.30 years (27-56 years). 63.61% of whom were over 40 years old, the majority of whom were pauciparous (45.46%) with an average parity of 2.91. Nulliparous women accounted for 18.18% of the total. The average duration of the disease was 7.56 months and could reach 48 months. The reason for consultation was dominated by anaemia with 77.27%. The fibroids varied in size (mean 7 cm) and sometimes exceeded 15 cm. Transfusion of concentrated red blood cells was almost constant (88.24%). Surgical treatment was myomectomy by twisting with 53.33% followed by hysterectomy in 26.67%. Management of fibroma delivered through the cervix were anemia frequently requiring a prior blood transfusion. Treatment remains surgery. Informing and educating patients about early consultation would improve the morbidity associated with this condition.
Lower urinary tract symptoms secondary to a vaginal leiomioma the female prostate: case report
Authors: Alcaraz Jennifer E. Reyes , Reyes Guadalupe Guerrero , Gonzalez Adrian Gutierrez , Velazquez Ricardo Hernandez , Maldonado Karen M. Loya , Cavazos Omar Treviño , Vazquez Jose I. Leyva , Cuevas Sara Y. Saca , Morales Juan C. Herrera
Published: January 2024

This is a case report of lower urinary tract symptoms secondary to a vaginal leiomioma “the female prostate”. A 45-year-old female patient with no significant personal history, sensation of a vaginal foreign body accompanied by lower urinary tract symptoms, on vaginal physical examination with a 7×7 cm deep tumor, increased consistency, not painful, without hemorrhage. Magnetic resonance imaging with hypointense T1 and T2 images, few linear hyperintense areas in T2, homogeneous postgadolinium enhancement 69×66×53 mm, solid tumor dependent on the vaginal vault. Tumor markers CA 19-9: 5.98 U/ml, CEA: 1.09 ng/ml and CA 125: 11.73 U/ml. Open surgery was performed in which a 8×6 cm tumor was found in the vaginal vault dependent on the posterior wall of the vagina. Histopathological report: conventional leiomyoma measuring 9×7.5 cm in long axes, without nuclear atypia. With resolution of symptoms in the lower urinary tract, with normal urinary frequency, without presence of urgency, without urinary incontinence or voiding symptoms. It is important to identify and diagnose lower urinary tract symptoms always, since they could be an initial manifestation of pelvic tumors in which the treatment approach should not be delayed.
Necrotizing fasciitis of the breast: case report and brief review of literature
Authors: Ibtissam Bellajdel , Ghizlane Graiti , Mimouni Ahmed , Saadi Hanane , Taheri Hafsa
Published: January 2024

Necrotizing fasciitis of the breast is a rare entity, with very few cases reported in the literature. It is rapidly progressive and can lead to sepsis and multi-organ failure without prompt medical and surgical management. In this particular case, a 71-year-old diabetic female presented with primary necrotizing fasciitis affecting her right breast. Upon arrival, she was in septic shock, exhibiting noticeable breast necrosis and nipple discharge. Immediate resuscitation was administered, followed by a muscle-sparing mastectomy. A vacuum-assisted closure (VAC) device dressing was applied during the procedure, and the patient was subsequently managed in intensive care postoperatively. As of now, the patient is free from the disease, and her wound has completely healed.
Acute pancreatitis in pregnancy: a rare case report
Authors: Khan Farha
Published: January 2024

Acute pancreatitis (AP) during pregnancy is a rare condition characterized by acute inflammation of pancreas due to premature activation of enzymes resulting in local pancreatic destruction and activation of an inflammatory cascade. This condition is most commonly caused by gall stones, hypertriglyceridemia, idiopathic factors. It’s very rare, incidence being 1 in 1000 to 1 in 12,000 pregnancies. Its more common in multigravida (75%) and relatively uncommon in first trimester. Patient usually present with acute severe pain abdomen radiating to back, nausea, vomiting, fever and anorexia. On examination there can be tachycardia, jaundice, epigastric tenderness, abdominal guarding and rigidity in severe cases. Serum amylase and lipase levels three times upper limit of normal value is diagnostic. Ultrasound remains imaging modality of choice. Vigorous fluid replacement is recommended. Prompt diagnosis and early treatment can prevent maternal and fetal morbidity and mortality. 23 years primigravida with 14 weeks of pregnancy came to outpatient with nausea and vomiting (10-15 episodes per day) and pain abdomen for 3 days. On abdomen examination epigastric tenderness was present. Serum amylase was 1246 Units/litre and serum lipase was 507.3 units/litre. She was given supportive care with IV fluids. Analgesics, antiemetics and antihistaminics were given. Gradually liquids were started and she recovered in 5 days.
Managing aplastic anaemia in pregnancy: a unique obstetric challenge
Authors: Makker Ishita , Hebbar Shripad , Lobo Viwal , Upadhyaya Rajani , Bhat Kavisha
Published: January 2024

Aplastic anaemia during pregnancy poses a unique obstetric challenge due to its rarity and potential life-threatening consequences. This article explores the intricate management of aplastic anaemia in pregnancy through a detailed case report of a 23-year-old primigravida. Despite the absence of clear guidelines, the patient successfully navigated pregnancy with multiple transfusions, presenting a compelling example of obstetric and neonatal success. The discussion digs into the complex relationship between pregnancy and aplastic anaemia, emphasizing the need for a multidisciplinary approach and careful decision-making to balance maternal and foetal well-being. The conclusion highlights the importance of a comprehensive strategy, including vigilant transfusion techniques, foetal growth monitoring, and delivery planning at tertiary centres.
Epidemiology and matrix metalloproteinases associated with pelvic organ prolapse: narrative review of the literature
Authors: Kayembe Antoine Tshimbundu , Muela Andy Mbangama , Baleka Alex Mutombo , Mushengezi Dieudonné Sengeyi , Tozin Rahma Raschid
Published: January 2024

Pelvic organ prolapse carries a risk of recurrence and leads to several disorders which bother the patient and alter her quality of life and her self-esteem. The objective of this review is to provide an overview of the published literature on the epidemiology and matrix metalloproteinases involved in the development of pelvic organ prolapse. We carried out online searches in electronic databases: Hinari, Google scholar, Pubmed and Embase; and manual searches of the references of each selected article to identify more studies not captured by the online search. Studies on adult women published in English and French over the past 25 years were collected. We excluded animal studies, those published multiple times, duplicates, letters, commentaries, editorial notes, congress report, clinical practice guidelines, case reports, studies of comorbidities (cervical cancer, fistulas, pregnancy), and those evaluating paraclinical examinations and treatment. A total of 153 articles were read and 84 studies were retained, including 33 on the prevalence of genital prolapse, 24 on its epidemiological and physiopathological risk factors, 7 on the recurrence of genital prolapse and its risk factors, 20 on the matrix metalloproteinases associated with pelvic organ prolapse and their regulatory factors. The identification of the epidemiology and matrix metalloproteinases associated with pelvic organ prolapse appears important for improving its treatment through appropriate advice and measures.
Atos linguageiros de ironia sarcástica
Authors: Cavalcante Mônica Magalhães , Brito Mariza Angélica Paiva , Faria Maria da Graça dos Santos
Published: January 2024

Neste trabalho, ponderamos sobre algumas características das interações que fazem uso de ironia sarcástica, vista aqui como uma estratégia argumentativa que só pode interpretada tendo em conta a totalidade da unidade de sentidos em contexto. Nosso objetivo é elaborar uma análise de textos contendo ironia linguisticamente marcada por processos referenciais e intertextuais. Os exemplos analisados, integrantes do domínio discursivo midiático, são ilustrativos da hipótese de que é necessário considerar, na interpretação da ironia, os aspectos interacionais (HUTCHEON, 2000), o circuito comunicativo, no qual deve ser contemplada a presença do terceiro, além de locutores e interlocutores; a heterogeneidade enunciativa e o cruzamento de pontos de vista; as redes referenciais na orientação argumentativa e os apelos intertextuais. Verificamos, ainda, as hipóteses de que a ironia tem como traço constitutivo o recurso à intertextualidade, com base nas reflexões de Sperber e Wilson (1990) sobre “menções” diretas e indiretas; a ironia só pode ser adequadamente analisada tendo em vista sua ocorrência na unidade de comunicação e de sentido em contexto amplo, que é o texto. Só na completude da interação em contexto o fenômeno da ironia pode ser inteiramente abarcado.
Neuromarketing
Authors: Varón Sandoval Alexander , Martín Castejón Pedro Juan , Zapata Castillo Lizeth Carolina
Published: January 2024

En este artículo de revisión se abordan los diferentes conceptos y teorías que se encuentran en torno al neuromarketing como un complemento a las estrategias del marketing tradicional. Se empieza por mostrar el camino que ha recorrido el segundo para llegar al primero, se continúa con la definición de esta nueva disciplina emergente dada por diferentes autores, se hace referencia a su evolución y los retos que tiene que afrontar. Se muestra un breve resumen sobre las estructuras cerebrales más importantes que se deben conocer para comprender el neuromarketing. Así mismo,se detallan las técnicas más utilizadas en los estudios. Por último, se evidencian los aportes que ha hecho el neuromarketing al marketing mix. Como principal conclusión, se encuentra que, aunque mucho se ha hablado del neuromarketing, poco se ha explorado, pues es una disciplina en desarrollo que puede interactuar con otras afines que logran enriquecer su esencia a partir del conocimiento del ser humano. Como cualquier disciplina en desarrollo, tiene detractores que lo consideran una herramienta de “manipulación”. En este artículo, se darán argumentos que hacen al neuromarketing una importante estrategia organizacional.
Prácticas del talento humano socialmente responsables en las medianas y grandes empresas de Ibagué, Colombia
Authors: Rubio Guerrero Germán , López Posada Laura Marcela , Hernández Arenas Edna Yisell
Published: January 2024

La gestión de las personas en las organizaciones requiere de una responsabilidad social y humana con sus colaboradores para el cumplimiento, no solo de los objetivos estratégicos y competitivos de las empresas, sino también para garantizar el bienestar y la calidad de vida de sus empleados. Las organizaciones, para asegurar una responsabilidad social interna, se apoyan en las prácticas del talento humano socialmente responsables, que son aquellas acciones que lleva a cabo la empresa para atraer, desarrollar, motivar y retener a los colaboradores. En este sentido, el propósito del estudio que dio origen a este artículo fue analizar las prácticas del talento humano socialmente responsables en las medianas y grandes empresas industriales y de servicios de Ibagué. La investigación fue de carácter cuantitativo, usando para el efecto técnicas de estadística descriptiva y multivariada. La muestra fue de 70 empresas, y fue seleccionada a través de un muestreo aleatorio estratificado a partir de una población de 85 organizaciones. A dicha muestra se le aplicó un cuestionario estructurado. Entre los resultados de esta investigación se destaca que, si bien la mayoría de estas organizaciones aplican conceptos relacionados con la responsabilidad social interna, y con las prácticas humanas socialmente responsables, aún les falta mucho por hacer en este sentido. Hay variables críticas que no reciben la atención requerida, entre ellas, la promoción, capacitación y desarrollo profesional de sus empleados,el equilibrio de la vida laboral-familiar, la discriminación de las mujeres y de la población discapacitada.
To the anniversary of the Department of Nonlinear Physics of Saratov State University
Authors:   Saratov State University, Beginin Evgeny , Morozova Maria ,   Saratov State University, Savin Aleksej ,   Saratov State University
Published: January 2024

2023 marks the 25th anniversary of the formation of the Department of Nonlinear Physics of Saratov State University. The department has developed and implements training programs on the general course of physics, physics of nonlinear processes, physics of wave processes in magnetic fields and structures.
Prediction of the Fatal Acute Complications of Myocardial Infarction via Machine Learning Algorithms
Authors: Ghafari Reza , Azar Amir Sorayaie , Ghafari Ali , Moradabadi Aghdam Fatemeh , Valizadeh Morteza , Khalili Naser , Hatamkhani Shima
Published: January 2024

Background: Myocardial infarction (MI) is a major cause of death, particularly during the first year. The avoidance of potentially fatal outcomes requires expeditious preventative steps. Machine learning (ML) is a subfield of artificial intelligence science that detects the underlying patterns of available big data for modeling them. This study aimed to establish an ML model with numerous features to predict the fatal complications of MI during the first 72 hours of hospital admission.
Methods: We applied an MI complications database that contains the demographic and clinical records of patients during the 3 days of admission based on 2 output classes: dead due to the known complications of MI and alive. We utilized the recursive feature elimination (RFE) method to apply feature selection. Thus, after applying this method, we reduced the number of features to 50. The performance of 4 common ML classifier algorithms, namely logistic regression, support vector machine, random forest, and extreme gradient boosting (XGBoost), was evaluated using 8 classification metrics (sensitivity, specificity, precision, false-positive rate, false-negative rate, accuracy, F1-score, and AUC).
Results: In this study of 1699 patients with confirmed MI, 15.94% experienced fatal complications, and the rest remained alive. The XGBoost model achieved more desirable results based on the accuracy and F1-score metrics and distinguished patients with fatal complications from surviving ones (AUC=78.65%, sensitivity=94.35%, accuracy=91.47%, and F1-score=95.14%). Cardiogenic shock was the most significant feature influencing the prediction of the XGBoost algorithm.
Conclusion: XGBoost algorithms can be a promising model for predicting fatal complications following MI.