bluuebunny/crossref_metadata_2025 huggingface dataset:
Differentiating factors of intra-articular injectables have a meaningful impact on knee osteoarthritis outcomes: a network meta-analysis
Authors: Phillips Mark , Vannabouathong Christopher , Devji Tahira , Patel Rahil , Gomes Zoya , Patel Ashaka , Dixon Mykaelah , Bhandari Mohit
Published: January 2020

Purpose

There are a number of developments in intra-articular therapies that have been determined to be differentiating factors within the classes of treatments. This study evaluated the efficacy and safety of intra-articular treatments of primary knee osteoarthritis in the short term (3 months follow-up), using a network meta-analysis design, while taking within-class differentiating factors into consideration.

Methods

A literature search of MEDLINE (through OVID), EMBASE (through OVID), Cochrane Central Register of Controlled Trials for all trials comparing intra-articular therapies was conducted on November 12, 2018. The treatments assessed were high molecular weight and low molecular weight hyaluronic acid injections, extended-release corticosteroids, standard-release corticosteroids, platelet-rich plasma, and saline. A frequentist network meta-analysis was conducted for each outcome.

Results

Sixty-four articles (9710 patients) met the inclusion criteria. High molecular weight hyaluronic acid (− 0.53, 95% CI − 0.81 to − 0.25) and PRP (− 0.79, 95% CI − 1.32 to − 0.26) were the only treatments with a confidence interval that lay completely above the MID threshold; however, PRP results varied within sensitivity analyses. For the function analysis, high molecular weight hyaluronic acid (SMD − 0.76, 95% CI − 1.30 to − 0.22) was the only treatment with a confidence interval entirely above the MID. Extended-release corticosteroid demonstrated a possible benefit in functional improvement (SMD − 0.98, 95% CI − 1.79 to − 0.17) compared to that of standard-release corticosteroid (SMD − 0.14, 95% CI − 0.72 to 0.44).

Conclusion

High molecular weight HA was the only treatment to surpass the MID for both pain and function outcomes. Extended-release corticosteroids may provide additional clinical benefit over standard-release corticosteroids. Platelet-rich plasma demonstrated possibly beneficial results; however, wide confidence intervals and sensitivity analyses made the conclusions of efficacy uncertain.

Level of evidence

Level 1. Systematic review of level 1 evidence.
The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children: a review
Authors: Van Paemel Ruben , Vlug Roos , De Preter Katleen , Van Roy Nadine , Speleman Frank , Willems Leen , Lammens Tim , Laureys Geneviève , Schleiermacher Gudrun , Tytgat Godelieve A. M. , Astrahantseff Kathy , Deubzer Hedwig , De Wilde Bram
Published: January 2020

Cell-free DNA profiling using patient blood is emerging as a non-invasive complementary technique for cancer genomic characterization. Since these liquid biopsies will soon be integrated into clinical trial protocols for pediatric cancer treatment, clinicians should be informed about potential applications and advantages but also weaknesses and potential pitfalls. Small retrospective studies comparing genetic alterations detected in liquid biopsies with tumor biopsies for pediatric solid tumor types are encouraging. Molecular detection of tumor markers in cell-free DNA could be used for earlier therapy response monitoring and residual disease detection as well as enabling detection of pathognomonic and therapeutically relevant genomic alterations.

Conclusion: Existing analyses of liquid biopsies from children with solid tumors increasingly suggest a potential relevance for molecular diagnostics, prognostic assessment, and therapeutic decision-making. Gaps remain in the types of tumors studied and value of detection methods applied. Here we review the current stand of liquid biopsy studies for pediatric solid tumors with a dedicated focus on cell-free DNA analysis. There is legitimate hope that integrating fully validated liquid biopsy–based innovations into the standard of care will advance patient monitoring and personalized treatment of children battling solid cancers.

What is Known:• Liquid biopsies are finding their way into routine oncological screening, diagnosis, and disease monitoring in adult cancer types fast.• The most widely adopted source for liquid biopsies is blood although other easily accessible body fluids, such as saliva, pleural effusions, urine, or cerebrospinal fluid (CSF) can also serve as sources for liquid biopsies

What is New:• Retrospective proof-of-concept studies in small cohorts illustrate that liquid biopsies in pediatric solid tumors yield tremendous potential to be used in diagnostics, for therapy response monitoring and in residual disease detection.• Liquid biopsy diagnostics could tackle some long-standing issues in the pediatric oncology field; they can enable accurate genetic diagnostics in previously unbiopsied tumor types like renal tumors or brain stem tumors leading to better treatment strategies
Local Public Corruption and Bank Lending Activity in the United States
Authors: Bermpei Theodora , Kalyvas Antonios Nikolaos , Leonida Leone
Published: January 2020

Using a conviction-based measure, we find that local (state-level) public corruption exerts a negative effect on the lending activity of US banks. Our baseline estimations show that the difference in public corruption between, for example, Alabama, where corruption is high, and Minnesota, where corruption is low, implies that banks headquartered in the former state grant 0.55% less credit (or $3.52 million for the average bank) ceteris paribus. Using proxies for relationship lending and monitoring, we also find that these bank characteristics weaken the negative effect of public corruption on lending. These results are robust to tests that address endogeneity, to the use of perception-based measures of corruption, and after controlling for credit demand conditions. In further analysis, we show that these effects are more evident for smaller banks and banks operating in a single state. These findings provide evidence that public corruption could facilitate information asymmetry in the lending market and, thus, could hinder local development by reducing bank credit.
Decomposing supply-side and demand-side impacts of climate change on the US electricity system through 2050
Authors: Steinberg Daniel C. , Mignone Bryan K. , Macknick Jordan , Sun Yinong , Eurek Kelly , Badger Andrew , Livneh Ben , Averyt Kristen
Published: January 2020

Climate change may affect the US electricity system through changes in electricity demand, mediated by increases in average surface temperature, and through changes in electricity supply, mediated by changes in both surface temperature and regional water availability. By coupling projections from four general circulation models (GCMs) with a state-of-the-art US electricity system model—the Regional Energy Deployment System (ReEDS)—this study evaluates both the isolated and combined effects of different climate-mediated drivers of US electricity system change through 2050. Comparing results across climate models allows us to evaluate which effects are robust to uncertainty in projected climate outcomes. Comparing effects of different drivers in isolation and in combination allows us to determine the relative contributions of the climate-mediated effects on system evolution. Our results indicate that national-level energy and economic impacts are largely driven by increases in electricity demand that follow from a consistent increase in surface air temperature that is largely robust to the choice of climate model. Other electricity system changes can be equally or more significant in some regions, but these effects are more regionally variable, less significant when aggregated to the national scale, and less robust to the choice of climate model. The findings show that the impacts of climate change on the electricity system can be understood in terms of fewer drivers and with greater certainty at the national level than at the regional level.
Fresh perspectives on TPACK: pre-service teachers’ own appraisal of their challenging and confident TPACK areas
Authors: Valtonen Teemu , Leppänen Ulla , Hyypiä Mareena , Sointu Erkko , Smits Anneke , Tondeur Jo
Published: January 2020

The present study is an extension of studies that measure pre-service teachers’ Technological Pedagogical Content Knowledge (TPACK) confidence. It provides new perspectives on pre-service teachers’ TPACK by shifting the focus to concrete concerns and strengths indicated by pre-service teachers. The target group consists of a cohort of first-year pre-service teachers (N = 86) from a Finnish university. The data used in this study were 86 lesson plans with integrated technology written by first-year pre-service teachers, with a specific section where students outlined their confident and challenging areas in the lesson plan. These sections were analysed quantitatively through the theoretical lens of TPACK. Four TPACK areas were found confident, challenging or both confident and challenging for students. For these first-year pre-service teachers, pedagogical knowledge played the most important role, and the outcomes concretize specific aspects of pedagogical knowledge that can be addressed to develop TPACK in teacher education. The results provide important perspectives on pre-service-teachers’ development of TPACK, revealing the important position of pedagogical knowledge and detailed perspectives on how pre-service teachers view their readiness to use ICT in education.
Primary Physical Science for Student Teachers at Kindergarten and Primary School Levels: Part I—Foundations of an Imaginative Approach to Physical Science
Authors: Corni Federico , Fuchs Hans U.
Published: January 2020

This is a theoretical paper in which we describe the motivation for and the design of a novel primary physics course for student teachers at kindergarten and primary school levels that uses cognitive tools such as metaphor, analogy, and narrative. The course has been taught in the master’s program in teacher education at three Universities over the last 5 years. It is based upon a model of the experience of forces of nature that draws upon four existing frameworks in physics, narratology, cognitive linguistics, and a theory of the development of cognitive tools. In short, the course is created upon the foundations of an imaginative, metaphoric and narrative, approach to physical science in general and to forces of nature in particular. Student teachers who learn science based upon this model can more directly relate to how children themselves experience nature and become confident narrators of stories of forces of nature. We describe the notion of Force of Nature (“The Gestalt of Force of Nature”) and explain what we mean by cognitive tools (“Cognitive Tools: Tools of Imagination”) before showing in what sense modern macroscopic physics is both metaphoric and narrative at its core (“An Imaginative Approach to Physical Science”). In “A Systemic Imaginative Approach to Primary Physics”, we give an outline of what is needed in order to apply the approach to a course for primary physics for student teachers. In the final section, we will discuss some questions and challenges raised by this approach and show that it is a viable avenue to bringing together science and the humanities, both for research and for teaching.
Sociodemographic, personal, and disease-related determinants of referral to patient-reported outcome-based follow-up of remote outpatients: a prospective cohort study
Authors: Schougaard Liv Marit Valen , de Thurah Annette , Christensen Jakob , Lomborg Kirsten , Maindal Helle Terkildsen , Mejdahl Caroline Trillingsgaard , Vestergaard Jesper Medom , Winding Trine Nøhr , Biering Karin , Hjollund Niels Henrik
Published: January 2020

Purpose

We examined the association between sociodemographic, personal, and disease-related determinants and referral to a new model of health care that uses patient-reported outcomes (PRO) measures for remote outpatient follow-up (PRO-based follow-up).

Methods

We conducted a prospective cohort study among outpatients with epilepsy at the Department of Neurology at Aarhus University Hospital, Denmark. Included were all persons aged ≥ 15 years visiting the department for the first time during the period from May 2016 to May 2018. Patients received a questionnaire containing questions about health literacy, self-efficacy, patient activation, well-being, and general health. We also collected data regarding sociodemographic status, labour market affiliation, and co-morbidity from nationwide registers. Associations were analysed as time-to-event using the pseudo-value approach. Missing data were handled using multiple imputations.

Results

A total of 802 eligible patients were included in the register-based analyses and 411 patients (51%) responded to the questionnaire. The results based on data from registers indicated that patients were less likely to be referred to PRO-based follow-up if they lived alone, had low education or household income, received temporary or permanent social benefits, or if they had a psychiatric diagnosis. The results based on data from the questionnaire indicated that patients were less likely to be referred to PRO-based follow-up if they reported low levels of health literacy, self-efficacy, patient activation, well-being, or general health.

Conclusion

Both self-reported and register-based analyses indicated that socioeconomically advantaged patients were referred more often to PRO-based follow-up than socioeconomically disadvantaged patients.
“Don’t leave me this way!” Drivers of parental hostility and employee spin-offs’ performance
Authors: Vaznyte Egle , Andries Petra , Demeulemeester Sarah
Published: January 2020

Many entrepreneurs commercialize an idea they initially developed as employees of an incumbent firm. While some face retaliatory reactions from their (former) employer, others are left alone or even supported. It is not clear, however, why some employee spin-offs face parental hostility while others do not, and to what extent this parental hostility affects employee spin-offs’ performance. Integrating the resource-based view with insights on competition and retaliation, we propose that parental hostility increases with the (perceived) competitive threat posed by an employee spin-off. Specifically, we advance employee spin-offs’ initial strategic actions (offering substitute products, hiring employees of the parent, and attempting to first develop the idea inside the parent) as key drivers of parental hostility and consequent spin-off performance. Results from a pooled dataset of 1083 employee spin-offs in Germany confirm that these initial strategic actions trigger parental hostility, which in turn, and contrary to expectations, positively affects employee spin-offs’ innovation and economic performance. These results advance the literature on employee spin-offs in several ways and have important practical implications.
Importance of livestock diseases identified using participatory epidemiology in the highlands of Ethiopia
Authors: Gizaw Solomon , Desta Hiwot , Alemu Biruk , Tegegne Azage , Wieland Barbara
Published: January 2020

Livestock are a major cornerstone for livelihoods of smallholders in the highlands of Ethiopia. However, infectious diseases are a key constraint in livestock production affecting productivity and food security. This study aimed to understand livestock producers’ perception on importance and epidemiology of livestock diseases. Participatory tools using focus group discussions were used to identify and rank livestock species, major livestock diseases, and their epidemiological patterns in smallholder systems. The study covered 17 districts in four regions, with two or threekebeles(smallest administrative unit) included in each district. To capture views of women and men, separate focus group discussions (FGD) were conducted. Data collected through proportional piling were used in generalized linear model analysis. Taking sheep as a reference, cattle were significantly the most preferred species with the odds of cattle scoring higher than sheep being 2.08 times (P = 0.000). Sheep and poultry were equally the second most important livestock, followed by goat and equine. There were no statistically significant differences between men and women FGD groups and between the four regions in their preference for livestock species. Twelve out of 28 identified livestock diseases were mentioned by at least 10% of FGDs in their list of five most important diseases. Blackleg, foot, and mouth disease, lumpy skin disease, anthrax, and bovine pasteurellosis were ranked as the top five diseases by both men and women focus groups. Reasons for high scores included suddenness of death, zoonosis risks, animal age groups and species affected, frequency of occurrence, rate of transmission in herds, curability, and inefficient vaccination. Seasonality and agro-ecology were also factors associated with disease occurrence. The study also documents that adult men and women are more involved in activities related to disease transmission compared with other family members. When asked about impacts of diseases, loss of livelihood, displacement, and infection with zoonoses were mentioned, with women considered equally affected as men. In conclusion, participatory tools allowed understanding disease priorities of and their perceived epidemiology in smallholder systems. The perceptions and priorities of men and women are very similar, and both need to be involved in designing health management interventions. Based on the findings of this study, the intervention strategies listed in the 2013 animal health strategy of Ethiopia (MoA and ILRI 2013) seem pertinent and need to be implemented to overcome the challenges of diseases.
A new kind of resin-based wet friction material: Non-woven fabrics with isotropic fiber networks as preforms
Authors: Fu Yewei , Zhou Le , Yin Tao , Luo Zhongyao , Li Hejin , Qi Lehua
Published: January 2020

As an alternative to short fibers, non-woven fabrics (NWFs) were made using different types of long fibers to optimize the performance of paper-based friction materials and their technology. In this investigation, the fillers and resin were impregnated into these NWFs to prepare three kinds of wet friction material. The tribological, mechanical, and thermal properties of the new wet friction material were studied. The results indicate that the dynamic friction coefficient of the new friction material is approximately 0.12 and the static friction coefficient is approximately 0.15; the better wear rate is 0.81334 × 10-14 m3·(N·m)-1. In addition, the temperature for 10% mass loss yielded 100 °C enhancement and the tensile strength was improved by 200%, compared to previously reported values. Most importantly, the advantages include a simple preparation flow, low cost, and resource conservation. This is a promising approach for the future development of paper-based friction materials.
Community structure: A comparative evaluation of community detection methods
Authors: Dao Vinh Loc , Bothorel Cécile , Lenca Philippe
Published: January 2020

Discovering community structure in complex networks is a mature field since a tremendous number of community detection methods have been introduced in the literature. Nevertheless, it is still very challenging for practitioners to determine which method would be suitable to get insights into the structural information of the networks they study. Many recent efforts have been devoted to investigating various quality scores of the community structure, but the problem of distinguishing between different types of communities is still open. In this paper, we propose a comparative, extensive, and empirical study to investigate what types of communities many state-of-the-art and well-known community detection methods are producing. Specifically, we provide comprehensive analyses on computation time, community size distribution, a comparative evaluation of methods according to their optimization schemes as well as a comparison of their partitioning strategy through validation metrics. We process our analyses on a very large corpus of hundreds of networks from five different network categories and propose ways to classify community detection methods, helping a potential user to navigate the complex landscape of community detection.
Micronutrient-fortified infant cereal improves Hb status and reduces iron-deficiency anaemia in Indian infants: an effectiveness study
Authors: Awasthi Shally , Reddy Narayan U. , Mitra Monjori , Singh Shweta , Ganguly Sanjeev , Jankovic Ivana , Grathwohl Dominik , Cercamondi Colin I. , Ghosh Apurba
Published: January 2020

Anaemia affects approximately 69 % of Indian children aged 6–12 months, with Fe deficiency (ID) being a common cause. The effectiveness of micronutrient-fortified infant cereal in improving Fe status and neurodevelopment was evaluated in non-anaemic and mildly anaemic Indian infants. An intervention group (IC) enrolled at age 6 months consumed 50 g/d of rice-based cereal providing 3·75 mg Fe/d as ferrous fumarate for 6 months (n80) and was compared with a matched static cross-sectional control group (CG) without intervention enrolled at age 12 months (n80). Mean Hb was higher in IC (118·1 (sd10·2) g/l)v.CG (109·5 (sd16·4) g/l) at age 12 months (adjusted mean difference: 9·7 g/l; 95 % CI 5·1, 14·3;P< 0·001), while geometric mean serum ferritin tended to be higher (27·0 (–1sd13·4, +1sd54·4)v.20·3 (–1sd7·5, +1sd55·0) ng/ml);P= 0·085) and soluble transferrin receptor was lower (1·70 (–1sd1·19, +1sd2·43)v.2·07 (–1sd1·29, +1sd3·33) mg/l;P= 0·014). Anaemia (23v.45 %;P= 0·007) and ID (17v.40 %;P= 0·003) were lower in ICv.CG. Bayley Scales of Infant and Toddler Development Third Edition scores for language (P= 0·003), motor development (P= 0·018), social-emotional (P= 0·004) and adaptive behaviour (P< 0·001), but not cognitive development (P= 0·980), were higher in ICv.CG. No significant difference in anthropometricZ-scores was observed between the groups. Consuming a micronutrient-fortified infant cereal daily for 6 months during complementary feeding promoted better Fe status while reducing the risk for anaemia and ID and was associated with superior neurodevelopmental scores.
The other side of the coin: Semantic dementia as a lesion model for understanding recollection and familiarity
Authors: Strikwerda-Brown Cherie , Irish Muireann
Published: January 2020

The syndrome of semantic dementia represents the “other side of the coin” to Alzheimer's disease, offering convergent evidence to help refine Bastin et al.’s integrative memory model. By considering the integrative memory model through the lens of semantic dementia, we propose a number of important extensions to the framework, to help clarify the complex neurocognitive mechanisms underlying recollection and familiarity.
The role of anxiety in the integrative memory model
Authors: Nephew Benjamin C. , Chumachenko Serhiy , Forester Brent P.
Published: January 2020

We suggest that the inclusion of anxiety, as one relevant mood factor, could enhance the implementation of the integrative memory model in research and the clinic. The role of anxiety in Alzheimer's disease neuroanatomy, symptomology, and progression is used as an example. Customization of the integrative memory model can establish strong foundations for pathology-specific models of memory deficits, enhancing the development of precision medicine applications.
A Neuropsychological Profile for Cerebrotendinous Xanthomatosis: A Single-Case Study
Authors: Bryant Andrew M. , Block Cady
Published: January 2020

Objective:

Cerebrotendinous xanthomatosis (CTX) belongs to a heterogeneous group of neurological disorders known as autosomal recessive cerebellar ataxias. Low awareness of CTX can result in misdiagnoses in the differential diagnostic process and may limit one’s ability to offer suitable recommendations. While neurodegeneration is a recognized manifestation of CTX, there is scant literature to characterize the nature of cortical symptoms and even less detailing of its associated neurocognitive and neuropsychiatric manifestations.

Method:

Based on the lack of representation of CTX in neuropsychological literature, we sought to present a case seen in a 39-year-old patient within our own clinic.

Results:

Evaluation of the patient’s neurocognitive functioning revealed global impairment consistent with a CTX diagnosis and neuroimaging findings noting significant cerebellar involvement.

Conclusions:

Neuropsychologists are increasingly called upon to make treatment recommendations and provide information that may be helpful in differential diagnosis as part of multidisciplinary teams. Referrals from neurology are common, and it is important for neuropsychologists to be aware of diseases that affect the central nervous system; CTX is one such example. The goal of this case study is to build awareness of this condition and increase interest in a more systematic approach to research and clinical care of this population.
Victor and Aladár Olgyay’s thermoheliodon: controlling climate to reduce climate control
Authors: Moffitt Lisa
Published: January 2020

Architectural models are reductive representations. Traits included or excluded from a model reflect designer intent as well as broader values held at the time of their construction. As such, models are reflective, acting as cultural mirrors of both conscious and unconscious priorities at the time of their construction. Models are also projective, offering new conceptions and interpretations about the subjects of their representations. Italo Calvino’s character Mr. Palomar reflects on the dialogic relationship between a model and reality.
Time‐Latitude Distribution of Prominences for 10 Solar Cycles: A Study Using Kodaikanal, Meudon, and Kanzelhohe Data
Authors: Chatterjee Subhamoy , Hegde Manjunath , Banerjee Dipankar , Ravindra B. , McIntosh Scott W.
Published: January 2020

Solar prominences are structures of importance because of their role in polar field reversal. We study the long‐term variation of the time latitude distribution of solar prominences in this article. To accomplish this, we primarily used the digitized disc‐blocked Ca II K spectroheliograms as recorded from Kodaikanal Solar Observatory for the period of 1906–2002. For improving the data statistics we included full disc H
images from Meudon and Kanzelhohe Observatory, which are available after 1980. We developed an automated technique to identify the latitudinal locations of prominences in daily images from all three data sets. Derived time‐latitude distribution clearly depicted poleward migration of prominence structures for 10 cycles (15–24). Unlike previous studies, we separated the rate of poleward migration during onset and near pole, using piece‐wise linear fits. In most cases, we found acceleration in poleward migration with the change occurring near
70° latitudes. The derived migration rates for such large number of solar cycles can provide important inputs toward understanding polar field buildup process.
Large Uncertainties in Runoff Estimations of GLDAS Versions 2.0 and 2.1 in China
Authors: Qi Wei , Liu Junguo , Yang Hong , Zhu Xueping , Tian Yong , Jiang Xin , Huang Xu , Feng Lian
Published: January 2020

Gauge observed runoff can reflect influences of both natural hydrological cycle and human intervention. The Global Land Data Assimilation System (GLDAS) 2.0 and 2.1 provide abundant runoff which are useful for water resources assessment in ungauged/poorly gauged regions. However, GLDAS2.0 and GLDAS2.1 runoff have only been validated and inter‐compared in very limited regions. In this study, they are evaluated and inter‐compared utilizing gauge observation in 11 large river basins in China. Results show their runoff have large uncertainties: absolute values of relative bias (|RB|) being above 39% and Nash‐Sutcliffe efficiency lower than 0.15 on average, but GLDAS2.1 is better. Both of them have large uncertainty in the Tibetan Plateau:|RB|are higher than 40%. The gap between GLDAS runoff and observations could attribute to both GLDAS system uncertainty and the fact that GLDAS does not consider human intervention. Therefore, cautions should be taken when using them in coupled human‐natural systems.
Comparison of Reanalysis Data Sets to Comprehend the Evolution of Tropical Cyclones Over North Indian Ocean
Authors: Malakar P. , Kesarkar A.P. , Bhate J.N. , Singh V. , Deshamukhya A.
Published: January 2020

Several reanalysis data sets are being used for understanding the role of environmental factors controlling tropical cyclones (TCs) evolution. Six reanalysis data sets, namely, European Center for Medium‐range Weather Forecast (ECMWF) ERA‐Interim (ERAI) reanalysis, Global Forecast System (GFS) analysis, Japan Meteorological Agency's 55‐year reanalysis projects reanalysis (JRA55), Modern‐Era Retrospective Analysis for Research and Applications, version 2 (MERRA2) reanalysis, NCEP Climate Forecast System Reanalysis (CFSR), and fifth generation of ECMWF atmospheric reanalysis of global climate (ERA5), have been evaluated for the representation of track, intensity, and structure of 28 TCs which occurred over North Indian Ocean (NIO) during the period 2006–2015. The errors in track, intensity, and minimum sea level pressure (MSLP) of TCs are estimated with respect to the best track data set of India Meteorological Department (IMD). The representation of inner core structure of TCs has been compared. The smallest error in the position of TCs center, MSLP, and maximum wind speed is found in GFS analysis followed by ERA5 and CFSR reanalysis, respectively. GFS and CFSR data sets capture the most intense stages of the TCs followed by the ERA5 data set, while the other three are unable to obtain intensification beyond the severe cyclonic storm stage. The structures of TCs are better represented in GFS analysis followed by ERA5 reanalysis. However, GFS analysis represents early intensification and, in some cases, overprediction of the category of TCs, especially during the most intensified stages (beyond cyclonic storms). Thus, GFS analysis captures the evolution of TCs more realistically, followed by the ERA5 reanalysis data set.
Convection in the Magnetosphere of Saturn During the Cassini Mission Derived From MIMI INCA and CHEMS Measurements
Authors: Kane M. , Mitchell D. G. , Carbary J. F. , Dialynas K. , Hill M. E. , Krimigis S. M.
Published: January 2020

An extensive analysis of Cassini Ion and Neutral Camera (INCA) and Charge Energy Mass Spectrometer (CHEMS) measurements of ~6–231 keV ion anisotropies acquired during selected spin and stare periods for nearly all mission orbits has been completed. Based on this analysis, we find that the computed azimuthal speed of Saturn's magnetodisk plasma increases within the inner and middle magnetosphere. Beyond the orbit of Titan, in the magnetotail, the calculated rotation speed remains roughly constant with increasing distance from Saturn. The component of convection parallel to Saturn's spin axis is smaller and on average nearly zero. The radial speed of plasma shows distinct local time dependence and increases outward with increasing distance down the magnetotail. The magnetodisk flow remains primarily azimuthal to large distances, indicating the plasma is still under the influence of Saturn as it transits across the nightside. Tailward flows have been observed in the region near the dawn and dusk magnetotail flanks. The plasma flow in the predawn quadrant is much more disorganized than that in the premidnight quadrant. The hydrogen and oxygen hot ion temperatures increase with decreasing distance to Saturn. Some plasma evidently escapes into a dusk boundary layer at the dusk magnetotail flank, while the remaining plasma primarily moves across the magnetotail and is entrained into the flow of a boundary layer at the dawn flank of the magnetotail. When scaled to the magnetopause standoff distance and corotation fraction, the convection speed of plasma in the magnetospheres of Jupiter and Saturn is similarly organized.
Detailed Structure of the Subducted Nazca Slab into the Lower Mantle Derived From Continent‐Scale Teleseismic P Wave Tomography
Authors: Portner Daniel Evan , Rodríguez Emily E. , Beck Susan , Zandt George , Scire Alissa , Rocha Marcelo P. , Bianchi Marcelo B. , Ruiz Mario , França George Sand , Condori Cristobal , Alvarado Patricia
Published: January 2020

Nazca subduction beneath South America is one of our best modern examples of long‐lived ocean‐continent subduction on the planet, serving as a foundation for our understanding of subduction processes. Within that framework, persistent heterogeneities at a range of scales in both the South America and Nazca plates is difficult to reconcile without detailed knowledge of the subducted Nazca slab structure. Here we use teleseismic travel time residuals from >1,000 broadband and short‐period seismic stations across South America in a single tomographic inversion to produce the highest‐resolution contiguous P wave tomography model of the subducting slab and surrounding mantle beneath South America to date. Our model reveals a continuous trench‐parallel fast seismic velocity anomaly across the majority of South America that is consistent with the subducting Nazca slab. The imaged anomaly indicates a number of robust features of the subducted slab, including variable slab dip, extensive lower mantle penetration, slab stagnation in the lower mantle, and variable slab amplitude, that are incorporated into a new, comprehensive model of the geometry of the Nazca slab surface to ~1,100 km depth. Lower mantle slab penetration along the entire margin suggests that lower mantle slab anchoring is insufficient to explain along strike upper plate variability while slab stagnation in the lower mantle indicates that the 1,000 km discontinuity is dominant beneath South America.
Effective Pore Fluid Bulk Modulus at Patchy Saturation: An Analytic Study
Authors: Monachesi Leonardo B. , Wollner Uri , Dvorkin Jack
Published: January 2020

A patchy saturated two‐layered porous rock, with each layer filled with a different fluid, is examined. We assume that this system is probed by an elastic wave having a wavelength much larger than the layers' thicknesses. We also assume that the diffusion length is smaller than the thickness of an individual layer, which implies hydraulic disconnection between layers. In the context of Gassmann's fluid substitution theory, we analytically derived an exact expression for the effective fluid bulk modulus assuming that both layers have the same porosity, dry frame, and mineral matrix properties. In addition we derived an approximate solution that works well at relatively high porosities. Both solutions are expressed as a weighted average of the arithmetic and harmonic averages of individual bulk moduli of the pore fluid. These weights are explicitly given as functions of the porosity, the fractional thicknesses of both layers, and the elastic moduli of the constituents. For the approximate solution, one does not require explicit knowledge of the shear modulus of the rock. The comparison with laboratory data showed that, in the case where a porous, isotropic rock is filled with water and gas, the approximate solution can be used to model the measured data for high values of water saturation.
The 2008 Eruptive Unrest at Cerro Azul Volcano (Galápagos) Revealed by InSAR Data and a Novel Method for Geodetic Modelling
Authors: Galetto Federico , Hooper Andrew , Bagnardi Marco , Acocella Valerio
Published: January 2020

Cerro Azul is one of the most active volcanoes in the western Galápagos Islands, but its unrest episodes are poorly studied. Unrest, which started in 2007, culminated in two eruptive phases from 29 May to 11 June 2008. We investigate this unrest and the associated eruptions using interferometric synthetic aperture radar (InSAR) data and geodetic modelling. To overcome the unwrapping errors affecting some of our InSAR data, we invert the wrapped phase directly by estimating the integer ambiguities simultaneously with the geophysical parameters. Our results highlight how the eruption was preceded by long‐term pre‐eruptive inflation (October 2007–April 2008). During the first eruptive phase, most of the magma responsible for the inflation fed the lateral propagation of a radial dike, which caused a first deflation of the magmatic reservoir. During the second eruptive phase, the further lateral propagation of the dike fed a radial eruptive fissure at the base of the edifice, causing further deflation of the magmatic reservoir. From the first to the second eruptive phase, the radial dike changed its strike propagating toward a topographic low between Cerro Azul and Sierra Negra.
The Role of the SO Radiative Effect in Sustaining the Volcanic Winter and Soothing the Toba Impact on Climate
Authors: Osipov Sergey , Stenchikov Georgiy , Tsigaridis Kostas , LeGrande Allegra N. , Bauer Susanne E.
Published: January 2020

Volcanic eruptions are an important climate driver. The impact of Pinatubo‐sized eruptions has been observed and is well constrained. The magnitude and duration of volcanic winter effects after supereruptions such as Toba remain disputed due to disagreement between the strong cooling predicted by models and much milder climate perturbations according to the paleodata. Here we present a reevaluated climate impact of a Toba‐sized supereruption based on up‐to‐date GISS ModelE simulations. In this study, we account for all known primary mechanisms that govern the evolution of the volcanic plume and their nonlinear interactions. The SO
radiative effects are evaluated for the first time in coupled climate simulations with the interactive atmospheric chemistry module. We found that SO
effects on photochemistry, dynamics, and radiative forcing are especially prominent. Due to strong absorption in ultraviolet, SO
feedback on photochemistry partially offsets the limiting effect associated with aerosol microphysical processes. SO
greenhouse warming soothes the radiative cooling exerted by sulfate aerosols. SO
absorption in the shortwave and longwave causes radiative heating and lofting of the volcanic plume, and boosts the efficiency of SO
impact on photochemistry. Our analysis shows that SO
lifetime and magnitude of effects scale up and increase with the amount of emitted material. For a Pinatubo‐sized eruption, SO
feedbacks on chemistry and dynamics are relevant only during the initial stage of the volcanic plume evolution, while local SO
concentrations are high. For a Toba‐sized eruption, SO
effects are as important as sulfate aerosols and produce a less extreme volcanic winter.
Neoarchean Synmagmatic Crustal Extrusion in the Transpressional Yilgarn Orogen
Authors: Zibra I. , Weinberg R. F. , Peternell M.
Published: January 2020

Positive feedback mechanisms between magmatism and transpression allow efficient extraction, transfer, and delivery of synorogenic granitic magma. Although many Archean orogens are dominantly transpressional and record voluminous production of synorogenic granites, the role of crustal magmatism in Archean tectonics has been so far little explored. We detail here the structural evolution of the Ballard shear zone, a major synorogenic, inclined transpressional shear zone from the upper‐crustal granite‐greenstone system of the Neoarchean Yilgarn Orogen (Western Australia). We show that the bulk of the three‐dimensional deformation was efficiently partitioned between greenstones and crystallizing granitic sheets, with the latter accommodating large amounts of orogen‐parallel strain through hypersolidus viscous flow. Other large synorogenic Yilgarn shear zones show a similar structural evolution, allowing the formulation of a general tectonomagmatic model. The positive feedback between protracted magmatism and transpression promoted lower‐ to middle‐crustal extraction and upward transfer of syntectonic magma. In upper‐crustal sink regions, the rheological dichotomy between cold and strong greenstones and hot and weak sheets of crystallizing granite allowed efficient kinematic partitioning, resulting in the extrusion of the partially molten shear zone cores. This sequence of events occurred repeatedly throughout the orogeny, following magma pulses, with the bulk of the shearing along each shear zone waning with the cooling of each syntectonic pluton. Synorogenic magmatism played therefore a major role in promoting and localizing transpressional deformation, and ultimately in shaping the architecture of the whole Yilgarn orogen.
Using Particle Tracking to Understand Flow Paths, Age Distributions, and the Paradoxical Origins of the Inverse Storage Effect in an Experimental Catchment
Authors: Wilusz D. C. , Harman C. J. , Ball W. P. , Maxwell R. M. , Buda A. R.
Published: January 2020

Many catchment studies use estimates of stream age distributions, including transit time distributions and StorAge Selection (SAS) functions, to make inferences about hydrologic processes and dominant flow paths. To improve the basis for such inferences, this study examined how different hydrologic flow paths contribute to the age distribution of discharge and evapotranspiration (ET) at the U.S. Department of Agriculture's Mahantango Creek experimental catchment in PA, USA, using the integrated surface‐subsurface hydrology model Parallel Flow‐Common Land Model with SLIM‐FAST particle tracking. The model tracked ET and five flow paths: direct runoff, overland flow, interflow, and shallow and deep groundwater. Over a 1‐year simulation, we found that individual flow paths release generallyolderage‐rank storage under wetting conditions (a direct storage effect). Paradoxically, total discharge originated fromyoungerage‐rank storage under wetting conditions (an inverse storage effect). This inverse storage effect was caused by the disproportionate increase in contributions from younger flow paths, particularly overland flow. This result suggests that where direct storage effects have been observed for individual sources of discharge (such as shallow groundwater), the same may not necessarily hold for total discharge and could in fact be reversed. Other findings include (1) a highly nonunique mapping between water age and flow path, (2) a “middle‐aged depression” in stream ages that cannot be fit by unimodal distributions (e.g., gamma and beta), (3) a taxonomy of transit time distribution shapes that occur during a typical storm, and (4) relatively young ET age distributions with a time‐invariant SAS function shape that reflects the parameterized depth distribution of root‐water uptake.
A Rainfall‐Runoff Model With LSTM‐Based Sequence‐to‐Sequence Learning
Authors: Xiang Zhongrun , Yan Jun , Demir Ibrahim
Published: January 2020

Rainfall‐runoff modeling is a complex nonlinear time series problem. While there is still room for improvement, researchers have been developing physical and machine learning models for decades to predict runoff using rainfall data sets. With the advancement of computational hardware resources and algorithms, deep learning methods such as the long short‐term memory (LSTM) model and sequence‐to‐sequence (seq2seq) modeling have shown a good deal of promise in dealing with time series problems by considering long‐term dependencies and multiple outputs. This study presents an application of a prediction model based on LSTM and the seq2seq structure to estimate hourly rainfall‐runoff. Focusing on two Midwestern watersheds, namely, Clear Creek and Upper Wapsipinicon River in Iowa, these models were used to predict hourly runoff for a 24‐hr period using rainfall observation, rainfall forecast, runoff observation, and empirical monthly evapotranspiration data from all stations in these two watersheds. The models were evaluated using the Nash‐Sutcliffe efficiency coefficient, the correlation coefficient, statistical bias, and the normalized root‐mean‐square error. The results show that the LSTM‐seq2seq model outperforms linear regression, Lasso regression, Ridge regression, support vector regression, Gaussian processes regression, and LSTM in all stations from these two watersheds. The LSTM‐seq2seq model shows sufficient predictive power and could be used to improve forecast accuracy in short‐term flood forecast applications. In addition, the seq2seq method was demonstrated to be an effective method for time series predictions in hydrology.
Correction: Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity
Authors: Zhang D. , Jin N. , Sun W. , Li X. , Liu B. , Xie Z. , Qu J. , Xu J. , Yang X. , Su Y. , Tang S. , Han H. , Chen D. , Ding J. , Tan M. , Huang M. , Geng M.
Published: January 2020

Following publication of this Article the Authors noted that a blot in Fig. 1c was misplaced and images were inadvertently duplicated in Supplementary Fig. S2 and Fig. S3. The corrected Fig.1 can be found below. The incorrect Supplementary files have been replaced online. The scientific conclusions of this paper were not affected.
ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway
Authors: Moskal Natalia , Riccio Victoria , Bashkurov Mikhail , Taddese Rediet , Datti Alessandro , Lewis Peter N. , Angus McQuibban G.
Published: January 2020

The accumulation of damaged mitochondria causes the death of dopaminergic neurons. The Parkin-mediated mitophagy pathway functions to remove these mitochondria from cells. Targeting this pathway represents a therapeutic strategy for several neurodegenerative diseases, most notably Parkinson’s disease. We describe a discovery pipeline to identify small molecules that increase Parkin recruitment to damaged mitochondria and ensuing mitophagy. We show that ROCK inhibitors promote the activity of this pathway by increasing the recruitment of HK2, a positive regulator of Parkin, to mitochondria. This leads to the increased targeting of mitochondria to lysosomes and removal of damaged mitochondria from cells. Furthermore, ROCK inhibitors demonstrate neuroprotective effects in flies subjected to paraquat, a parkinsonian toxin that induces mitochondrial damage. Importantly, parkin and rok are required for these effects, revealing a signaling axis which controls Parkin-mediated mitophagy that may be exploited for the development of Parkinson’s disease therapeutics.
Accurate quantification of circular RNAs identifies extensive circular isoform switching events
Authors: Zhang Jinyang , Chen Shuai , Yang Jingwen , Zhao Fangqing
Published: January 2020

Detection and quantification of circular RNAs (circRNAs) face several significant challenges, including high false discovery rate, uneven rRNA depletion and RNase R treatment efficiency, and underestimation of back-spliced junction reads. Here, we propose a novel algorithm, CIRIquant, for accurate circRNA quantification and differential expression analysis. By constructing pseudo-circular reference for re-alignment of RNA-seq reads and employing sophisticated statistical models to correct RNase R treatment biases, CIRIquant can provide more accurate expression values for circRNAs with significantly reduced false discovery rate. We further develop a one-stop differential expression analysis pipeline implementing two independent measures, which helps unveil the regulation of competitive splicing between circRNAs and their linear counterparts. We apply CIRIquant to RNA-seq datasets of hepatocellular carcinoma, and characterize two important groups of linear-circular switching and circular transcript usage switching events, which demonstrate the promising ability to explore extensive transcriptomic changes in liver tumorigenesis.