bluuebunny/crossref_metadata_2025 huggingface dataset:
Response of lake dynamics to climate change in the Qilian Mountains from 1990 to 2020
Authors: Zhao Tingting , Zhang Xiaoping , Li Zongxing , Chen Hu , Li Jiayao
Published: June 2023

Lakes are sensitive indicators of climate change. Based on the lake dataset and Landsat remote sensing data, we analyzed the changes in area and number of lakes(> 1km2) in the Qilian Mountains from 1990 to 2020, as well as the boundary changes of lakes(> 100km2). In addition, we discussed the impact of climate change on lake area. The results showed that: (1) From 1990 to 2020, the total area and total number of lakes in the Qilian Mountains showed an overall increasing trend, with a total area increase of 492.47km2 and a total number increase of 10. Among them, Qinghai Lake, Hala Lake, Xiao Qaidam Lake, and Nauru Nor Lake showed an overall expansion trend, while Caka Salt Lake and Da Caidam Lake showed an overall shrinking trend. (2)The main reasons for the expansion of Qinghai Lake and Hala Lake was the increase in precipitation, while the main reason for the expansion of Xiao Qaidam Lake and Nauru Nor Lake was the increase in temperature and precipitation. The main reason for the shrinkage of Caka Salt Lake was the enhancement of evapotranspiration. (3) Lakes in the Qilian Mountains were mainly expanding, which has a good promoting effect on improving the ecological environment of this region and even larger area. However, we should also pay attention to problems such as floods and salt-alkali land caused by lake expansion in a timely manner. In addition, governments and all sectors of society should take corresponding measures to alleviate further shrinkage of Caka Salt Lake.
A transcriptome approach evaluating the effects of Atractylenolide Ⅰ on the secretion of estradiol and progesterone in feline ovarian granulosa cell
Authors: guo yuli , Liu Junping , Zhang Shuangyi , Sun Di , Dong Zhiying , Cao Jinshan
Published: June 2023

Atractylodes macrocephala Koidz (AMK) as eartraditional oriental medicine has been used in the treatment of threatened abortion. Atractylenolide I (AT-I) is one of the major bioactive components of AMK. This study aimed to investigate the effect of AT-I on the secretion of estradiol (E2) and progesterone (P4) of feline ovarian granulosa cells (FOGCs) which is necessary for pregnancy. At first, the prolifeation of FOGCs after AT-I treatment was measured by CCK-8. Then, the synthesis of E2 and P4 were measured by ELISA. Lastly, transcriptome sequencing was used to detect the DEGs in the FOGCs, and RNA-Seq results were verified by RT-qPCR and biochemical verification. It was found that AT-I could promote proliferation and the secretion of E2 and P4 in FOGCs; after AT-I treatment, 137 significantly DEGs were observed, out of which 49 were up-regulated and 88 down-regulated. The DEGs revealed significant enrichment of 52 GO terms throughout the differentiation process (P < 0.05) as deciphered by Gene Ontology enrichment analysis. Kyoto Encyclopedia of Genes and Genomes analysis manifested that the DEGs were successfully annotated as members of 155 pathways, with 23 significantly enriched (P < 0.05). A relatively high number of genes were enriched for the cholesterol metabolism, ovarian steroidogenesis, and biosynthesis of unsaturated fatty acids. Furthermore, the contents of the total cholesterol and low-density lipoprotein cholesterol were decreased by AT-I treatment in the cell culture supernatant. The results indicated that AT-I could increase the ability of FOGCs to secrete E2 and P4, which might be achieved by activation of cholesterol metabolism.
The Impact of Surgical Volume on Outcomes in Newly Diagnosed Colorectal Cancer Patients Receiving Definitive Surgeries
Authors: Yeh Chiu-Mei , Lai Tzu-Yu , Hu Yu-Wen , Teng Chung-Jen , Huang Nicole , Liu Chia-Jen
Published: June 2023

Purpose:
Colorectal cancer (CRC) patients who receive cancer surgeries by higher-volume providers may have better outcomes. Our previous studies support the notion that surgeon volume is more important to patient outcomes compared with hospital volume. However, the definitions of surgical volume may affect the results. We aim to analyze the effects of different definitions of surgical volume on patient outcome.
Methods: We conducted a nationwide population-based study in Taiwan that enrolled all patients who underwent definitive surgery for newly diagnosed CRC between 2005 and 2016. We divided all patients into four quartiles according to different definitions of hospital and surgeon volumes, including total, cumulative, and annual volumes. The primary outcome was a five-year mortality rate, which was analyzed using a frailty model for Cox regression. We adjusted for patientand provider characteristics to control for potential confounding factors. The discrimination model of the different definitions of surgical volume was estimated by the Akaike information criterion (AIC) and the Bayesian information criterion (BIC).
Results:
We included 100,009 newly diagnosed CRCpatients in this study, including 55,849 (55.8%) males and 44,160 (44.2%) females, of median age 66 years at diagnosis (range, 20–105 years). The five-year mortality rates were reversely associated with hospital and surgeon volume quartiles, respectively. After adjustment for the patient and provider characteristics, we found that surgeon volume, but not hospital volume, remained an independent predictor of death (p < 0.001). We further compared three definitions of surgical volume and found cumulative volume provided the lowest AIC and BIC for the prediction of five-year mortality. After adjusting for basic characteristics of patient, hospital, and physician, CRC patients in the high hospital and high surgeon cumulative volume group had the significantly lowest risk of mortality (HR 0.72; 95% CI 0.68–0.75; p< 0.001), followed by the low hospital and high surgeon volume group (HR 0.80; 95% CI 0.77–0.83; p < 0.001) as compared with the low hospital and low surgeon volume group.
Conclusion:
CRC patients receiving definitive surgery by higher-volume providers had better outcomes, especially where surgeon volume may play a more important role than hospital volume. The cumulative volume could predict five-year mortality of the study cohort better than total and annual volume.
TSH Receptor Reduces Hemoglobin S Polymerization, Increases Deformability and Adhesion of Sickle Erythrocytes
Authors: Mendonça-Reis Evelyn , Guimarães-Nobre Camila Cristina , Teixeira-Alves Lyzes Rosa , Berto-Junior Clemilson
Published: June 2023

Background:
SCD is a hereditary disorder caused by genetic mutation in the beta-globin gene, resulting in abnormal hemoglobin, HbS, that forms sickle-shaped erythrocytes. Patients with SCD have endocrine disorders and it was described that 7% of these patients have clinical hypothyroidism. Recent studies have shown that mature erythrocytes possess TSH receptors. Thus, we aimed to assess the effects of TSH on SCD erythrocytes. The experiments were conducted using different concentrations of TSH (1, 2, 3, and 5 mIU/L). In HbS polymerization assay, erythrocytes were exposed to TSH in hypoxia to induce polymerization, and measurements taken for 30 minutes. The deformability assay was made using Sephacyl-S 500 columns to separate deformable from non-deformable cells. Static adhesion test utilized thrombospondin to assess erythrocyte adhesion in the presence of TSH. TSH at all contractions were able to reduce polymerization of HbS and increase deformability. The static adhesion of erythrocytes at the lowest concentrations of 1 and 2 mIU/ L were increased, but at higher contractions of 3 and 5 mIU/L, static adhesion was not modulated. The results suggest that TSH has potential involvement in the pathophysiology of sickle cell disease by inhibiting HbS polymerization, positively modulating deformability, and impacting static adhesion to thrombospondin.
Antibiotic stewardship using ePOCT+, a digital health clinical decision support algorithm for paediatric outpatient care: results from the DYNAMIC Tanzania cluster randomized controlled trial
Authors: Tan Rainer , Kavishe* Godfrey , Kulinkina* Alexandra , Luwanda* Lameck , Renggli Sabine , Mangu Chacha , Ashery Geofrey , Jorram Margaret , Mtebene Ibrahim , Agrea Peter , Mhagama Humphrey , Vonlanthen Alan , Faivre Vincent , Thabard Julien , Levine Gillian , Pogam Marie-Annick Le , Keitel Kristina , Taffé Patrick , Ntinginya** Nyanda , Masanja** Honorati , D'Acremont** Valérie
Published: June 2023

Excessive antibiotic use and antimicrobial resistance are major global public health threats. We developed ePOCT+, a digital Clinical Decision Support Algorithm in combination with C-reactive protein test, haemoglobin test, pulse oximeter and mentorship, to guide healthcare providers in managing acutely sick children under 15 years old. To evaluate the impact of ePOCT + compared to usual care, we conducted a cluster-randomized controlled trial in Tanzanian primary care facilities (NCT05144763). Over 11 months, 23 593 consultations were included in 20 ePOCT + health facilities, and 20 713 in 20 usual care facilities. Antibiotics were prescribed in 23.2% of consultations in ePOCT + facilities, and 70.1% in usual care facilities (adjusted difference, -46.4%, 95% confidence interval (CI) -57.6 to -35.2). Day 7 clinical failure in ePOCT + facilities was non-inferior to usual care facilities (adjusted relative risk 0.97, 95% CI 0.85 to 1.10). Using ePOCT + could help address the urgent problem of antimicrobial resistance by safely reducing antibiotic prescribing.

*Shared second authorship; contributed equally.
**Shared last authorship; contributed equally.
Targeted mild hypercapnia after out-of-hospital cardiac arrest is associated with favourable cardiovascular effects. A sub-study of the TAME cardiac arrest trial.
Authors: Melberg Mathias Baumann , Flaa Arnljot , Andersen Geir Øystein , Sunde Kjetil , Bellomo Rinaldo , Eastwood Glenn , Olasveengen Theresa Mariero , Qvigstad Eirik
Published: June 2023

Purpose:
Hypercapnic acidosis may elicit detrimental haemodynamic effects in critically ill patients. We aimed to investigate the consequences of targeted mild hypercapnia (TMH) versus targeted normocapnia (TN) on pulmonary vascular resistance and right ventricular function in patients
resuscitated from out-of-hospital cardiac arrest (OHCA).
Methods:
Single-centre, prospective, sub-study of the Targeted Therapeutic Mild Hypercapnia After
Resuscitated Cardiac Arrest (TAME) trial. Patients were randomised to TMH (PaCO2 = 6.7–7.3 kPa) or TN (PaCO2 = 4.7-6.0 kPa) for 24 hours. Haemodynamic assessment was performed with right heart catheterisation and serial blood-gas analyses every 4th hour for 48 hours.
Results:
We studied 84 patients. Mean pH was 7.24 (95 % CI 7.22–7.30) and 7.32 (95 % CI 7.31–7.34) with TMH and TN, respectively (P-group < 0.001). Pulmonary vascular resistance index (PVRI), pulmonary artery pulsatility index, and right atrial pressure did not differ between groups (P-group > 0.05). Mean cardiac index was higher with TMH (P-group < 0.001): 2.0 (95 % CI 1.85–2.1) vs 1.6 (95 % CI 1.52–1.76) L/min/m2. Systemic vascular resistance index was 2579 dyne-sec/cm-5/ m2 (95 % CI 2356–2830) with TMH, and 3249 dyne-sec/cm-5/ m2 (95 % CI 2930 – 3368) with TN (P-group < 0.001). Stroke volumes (P-group = 0.013) and mixed venous oxygen saturation (P-group < 0.001) were higher in the TMH-group.
Conclusion:
In resuscitated OHCA patients, targeting mild hypercapnia did not increase PVRI or worsen right ventricular function compared to TN. TMH comparatively improved cardiac performance and mixed venous oxygen saturation.
Trial registration number: NCT03114033
Effects of epibrassinolide on wheat seedling growth and antioxidant properties under Cd2+ stress
Authors: Shen Guo-Ming
Published: June 2023

This study investigates the physiological changes of two varieties wheat (Triticum aestivum L.) seedlings namely LX77 and JM22 by spraying different concentrations of epibrassinolide (EBR) under Cd2+ stress using a hydroculture. Results showed that after foliar application of different concentrations of EBR, seedling growth properties, chlorophyll contents, root vigor, osmotic regulators, malondialdehyde (MDA) and H2O2 contents, relative conductivity, antioxidant enzyme activities were changed in both LX77 and JM22, and the optimal exogenous EBR concentration is 0.01 or 0.1 mg·L− 1.
Harm Reduction Workforce, Behavioral Health, and Service Delivery: A Cross Sectional Study
Authors: Zerden Lisa , Ware Orrin D. , Lombardi Brooke N. , Lombardi Brianna M.
Published: June 2023

Background
Despite recent financial and policy support for harm reduction, little is known about the harm reduction workforce—the specific types of workers within organizations who design, implement, and actualize harm reduction services. This exploratory mixed-methods study asked: (1) Who constitutes the harm reduction workforce? (2) Who provides behavioral health services within harm reduction organizations? (3) Do referrals differ by type of harm reduction worker?
Methods
Purposive sampling techniques were used to distribute an electronic survey to U.S.-based harm reduction organizations. Descriptive statistics were conducted. Multivariate binary logistic regression models examined the associations (a) between the odds of the referral processes at harm reduction organizations and (b) between the provision of behavioral health services and distinct types of organizational staff. Qualitative data were analyzed using a hybrid approach of inductive and thematic analysis.
Results
Data from 41 states and Washington D.C. were collected (N = 168; 48% response rate). Four primary types of workers were identified: community health/peer specialists (87%); medical/nursing staff (55%); behavioral health (49%); and others (34%). About 43% of organizations had a formal referral process; among these, only 32% had follow-up protocols. Qualitative findings highlighted the broad spectrum of behavioral health services offered and a broad behavioral health workforce heavily reliant on peers. Unadjusted results from multivariate models found that harm reduction organizations were more than 5 times more likely (95% CI=[1.91, 13.38]) to have a formal referral process and 6 times more likely (95% CI=[1.74, 21.52]) to have follow-up processes when behavioral health services were embedded. Organizations were more than two times more likely (95% CI=[1.09, 4.46]) to have a formal referral process and 2.36 (95% CI=[1.11, 5.0]) times more likely to have follow-up processes for referrals when behavioral health providers were included.
Conclusions
The composition of the harm reduction workforce is occupationally diverse. Understanding the types of services offered, as well as the workforce who provides those services, offers valuable insights into staffing and service delivery needs of frontline organizations working to reduce morbidity and mortality among those who use substances. Workforce considerations within harm reduction organizations are increasingly important as harm reduction services continue to expand.
Ascophyllum nodosum seaweed extract in Inga edulis seedlings under drought and the potential of phenotypic plasticity
Authors: Santos Cleberton Correia , Silva Antônio Augusto Souza da , Oliveira Caio Henrique de Carvalho , Silverio Juliana Milene , Dias Anderson dos Santos , Linné Jéssica Aline , Scalon Silvana de Paula Quintão , Alovisi Alessandra Mayumi Tokura
Published: June 2023

Studies aiming alleviating the effect of drought on plants have increased, and the use of seaweed extract has been a sustainable and promising management for stress tolerance. Thus, this work aimed to evaluate the role of Ascophyllum nodosum (L.) Le Jolis seaweed extract (ANE) in Inga edulis Mart. seedlings under drought and post-stress. The seedlings were cultivated under: 1) control (daily irrigation), 2) drought by water restriction – WR (irrigation suspension), 3) WR + 15 mL L-1 ANE, 4) WR + 30 mL L-1 ANE, and 5) WR + 45 mL L-1 ANE, and evaluated in two periods: i) SWD - when the seedlings showed symptoms of water deficit, and ii) REC: recovery (post-stress) - resumption of irrigation for 60 days. The application of 45 mL ANE contributed to the N content of seedlings under drought and post-stress. The order of nutritional requirement was similar for N, Ca, and Mg, but P and K varied according to the evaluation periods under drought. The application of 30 and 45 mL L-1 ANE contributed in the post-stress, favoring the quantum efficiency of photosystem II in response to the higher nutrient content in plant tissue, reflecting on growth in the REC. ANE increased proline content as osmoprotection mechanism during SWD and promoted an efficient recovery. The application of 30 and 45 mL ANE contributes to induction of stress tolerance in I. edulis seedlings under drought, and it favors recovery of plants in the post-stress due to phenotypic plasticity, which becomes a promising management for this species.
Disparities in the burden of prostate cancer and its trends in the Western Pacific Region, 1990-2019
Authors: Yang Shijia , Zhou Jing , Zhang Zhaoyu , Zou Jian , Peng Minghui , Li Xiaopan , Jiang Sunfang
Published: June 2023

Background
Prostate cancer's (PC) burden and its temporal trend have been poorly studied. This study aimed to fill this gap by evaluating regional disparities of PC burden and trends in China, the Western Pacific Region (WPR), and the World from 1990 to 2019.
Methods
According to the estimation of prostate cancer disease burden in the global burden of disease 2019 (GBD 2019), we applied GBD 2019 analytical tools to compare PC incidence, mortality, prevalence, the years lived with disability (YLDs), years of life lost (YLLs) and disability-adjusted life-years (DALYs) from 1990 to 2019 in China, the WPR, and the World. Disease burden trends between 1990 and 2019 were evaluated using average annual percent change (AAPC) estimated by Joinpoint regression analysis.
Results
There were 268434.51 (95% UI: 229573.18, 329220.58) new PC cases, 2044006.62 (95% UI: 1749910.09, 2541958.35) PC patients, and 90275.23 (95% UI: 76005.63, 109056.31) deaths due to PC in 2019 in the WPR. The trend for DALYs (AAPC=-0.31 (95% CI=-0.35, -0.27)%, P < 0.001) decreased. With the increase in age, PC incidence (AAPC = 91.07 (95%CI = 77.40, 105.79)%, P < 0.001), mortality (AAPC = 114.62 (95%CI = 102.49, 127.48)%, P < 0.001), YLLs (AAPC = 84.23 (95%CI = 74.18, 94.86)%, P < 0.001), and DALYs (AAPC = 84.61 (95%CI = 74.25, 95.60)%, P < 0.001) rates increased notably. Our analysis shows regional differences in PC burden in the WPR from 1990 to 2019. The PC burden in most high-income countries decreased (High-Socio-Demographic-Index (SDI) countries: AAPC 95%CI=-1.46(-1.55, -1.38)%, P < 0.001). The age-standardized DALYs of PC increased in most low-income countries (Low-SDI countries: AAPC 95%CI = 0.41(0.35, 0.47)%, P < 0.001). The age-standardized DALYs of PC in middle-income countries increased or had no apparent changes, except in China (AAPC=-0.24(95% CI=-0.27, -0.2)%, P < 0.001) and Kiribati (AAPC=-0.62(95% CI = -0.83, -0.41)%, P < 0.001), which decreased.
Conclusions
There was a growing burden and profound imbalance in prostate cancer from 1990 to 2019 in the WPR. Our study emphasized the urgent need for tailored prevention and control strategies for PC to reduce disparities in the PC burden and promote health governance in the WPR. Public health strategies effective in high-income countries and some countries in the WPR could be used as references for developing PC prevention and intervention strategies according to local conditions.
Systematic surveillance tools to reduce rodent pests in disadvantaged urban areas can empower communities and improve public health
Authors: Awoniyi Adedayo , Barreto Ana , Argibay Hernan , Santana Juliet , Palma Fabiana , Riviere-Cinnamond Ana , Dobigny Gauthier , Bertherat Eric , Ferguson Luther , Belmain Steven , Costa Federico
Published: June 2023

Rodents have been reported to be associated with the transmission of major public health diseases as well as agricultural and economic losses. The lack of site-specific and national standardised rodent surveillance in several disadvantaged communities has rendered interventions targeted towards rodent control as often ineffective. Here, by using the example from a study in The Bahamas, we present a unique experience in which, through multidisciplinary and community engagement, we simultaneously developed a standardised national surveillance protocol, and performed two parallel but integrated activities: 1) eight days of theoretical and practical training of selected participants; and 2) a three-month post-training pilot rodent surveillance in the urban community of Over-the-Hill, Nassau, The Bahamas. In order to account for cultural and environmental conditions in The Bahamas, we modified the Centers for Diseases Control and Prevention (CDC) exterior and interior rodent evaluation form and other instruments that have been previously validated for evaluating rodent infestation (tracking plates and snap trapping) to test and to reach a standardised site-specific rodent surveillance protocol for The Bahamas. Our engagement with local communities pointed towards ownership problems, unapproved refuse storage, exposed garbage, sources of animal food, poor bulk wastes management and structural deficiencies as major factors fueling rodent proliferation in the study area. Accordingly, results from our pilot survey using a generalized linear model with a logistic link and binomially distributed error structure confirmed that these variables are significantly correlated with the rodent activities reported and monitored across the study area. Our successful experience could serve as a reference to encourage a standardised protocol for monitoring rodent activities in many disadvantaged urban settings of the Global South, while also aiding the holistic understanding of rodent proliferation. Through this case-study and pilot program, we advocate for the feasibility of developing sustainable rodent control interventions that can be acceptable for both local communities and public authorities, especially through the involvement of a multidisciplinary team of professionals and community members.
Exploration of the shared molecular signatures in monkeypox and HIV infection using integrated bioinformatics analysis
Authors: Li Shifang , Gong Meijiao
Published: June 2023

Monkeypox (Mpox) was declared a public health emergency of international concern by WHO, and there is growing evidence of an association between mpox and HIV infection. However, the underlying mechanism is largely unknown. In this study, using integrated bioinformatics analysis, the underlying mechanisms and important genes involved in the crosstalk between HIV and Mpox were investigated. CHMP2A was shown to be significantly upregulated after Mpox infection and in HIV-infected CD8+ T cells utilizing DEG and weighted gene co-expression network (WGCNA) analysis. Following that, the HIV scRNA-seq dataset was examined further to establish the expression level and location of the CHMP2A gene. CHMP2A was shown to be significantly expressed in CD8+ exhaustion T cells, and its expression increased in CD8+ exhaustion T cells from HIV patients. Interestingly, pseudotime analysis revealed that CHMP2A was linked to the differentiation of CD8+ effector memory T cells into CD8+ exhaustion T cells. In addition, TAF7 and IRF3 were identified as possible upstream transcription factors that regulate CHMP2A by pySCENIC analysis. Finally, applying virtual screening of 4381 approved drugs and molecular dynamics simulations analysis, ZINC000027990463 has the potential to be a drug that targets CHMP2A. Overall, our results reveal key biomarkers that are potentially involved in the crosstalk between Mpox and HIV, which provides new insights into the mechanisms of disease co-infection. Further investigation is needed to determine the function of CHMP2A in CD8+ T cells following infection.
Stem Carbohydrate Richness in Two Cycad Species
Authors: Marler Thomas E.
Published: June 2023

The pachycaulous stem of cycad plants enables the storage of abundant nonstructural carbohydrates. Cycas revoluta Thunb. and Zamia furfuracea L.f. stems were analyzed for starch and 15 sugars to determine carbohydrate richness. All 15 sugars were detected in both species. The tetrasaccharide stachyose and the disaccharide sucrose comprised most of the sugar content. Total sugar content of these cycad stems was 330 to 360 mg·g−1 and was similar to starch content. The stems of these two species were composed of 64% to 79% nonstructural carbohydrates. The cycad stem is ideally designed to store and mobilize nonstructural carbohydrates to support sink activity when needed, and stachyose may play a prominent functional role.
The Use of Silicon Substrate Amendments to Decrease Micronutrient Concentrations at Varying Micronutrient Fertility Rates with Cannabis sativa ‘Auto CBG’
Authors: Veazie Patrick , Jeong Ka Yeon , Ballance M. Seth , Whipker Brian E.
Published: June 2023

Many abiotic factors impact the yield and growth of Cannabis sativa (cannabis). Cannabis has been reported to be a bio-accumulator of heavy metals. For growers who are targeting floral production and other byproducts for human consumption, this is a concern. Silicon (Si) has been examined as a beneficial plant element to limit the uptake of heavy metals in a variety of crops. The objective of this study was to determine the impact of Si on heavy metal micronutrient uptake and plant growth for greenhouse-cultivated cannabis at varying Si substrate amendments. ‘Auto CBG’ plants were grown in a 70:30 peat:perlite substrate with one of three varying calcium silicate (CaSiO3) (Si) substrate amendment rates, Si0X, Si0.5X, or Si1X (of 0.0, 1.04, and 2.07 kg⋅m−3 CaSiO3), and one of three micronutrient fertility treatments, M1X [0.49 boron (B), 0.19 copper (Cu), 4.02 iron (Fe), 0.99 manganese (Mn), 0.01 molybdenum (Mo), and 0.20 zinc (Zn) mg⋅L−1], M2X, or M4X, using a modified Hoagland’s solution, creating a 3 × 3 factorial. Plants grown with a Si1X substrate amendment exhibited a significantly lower iron concentration in the foliage and root tissue when compared with those grown in a substrate without Si. After 6 weeks of growth, Si0X plants that received a M4X fertility rate exhibited greater foliar micronutrient concentrations of B, Mn, Zn, Fe, and Cu than plants that received a Si substrate amendment when provided a M4X fertility rate. Additionally, lower micronutrient concentrations in floral tissue were observed in plants that received a Si substrate amendment for M2X and M4X when compared with plants that did not. Silicon substrate amendments had no impact on the cannabinoid concentration or plant growth metrics after 12 weeks of growth. This research suggests that using a Si substrate amendment in a greenhouse production system can limit excessive uptake and accumulation of micronutrients in the foliage, roots, and floral material of cannabis without negative impacts on plant growth or cannabinoid concentrations.
Integrasi Jalur Evakuasi pada Bangunan Publik Bertingkat Menggunakan Pendekatan Space Syntax
Authors: Raniasta Yohanes Satyayoga
Published: June 2023

Title: Integration of Multi-stories Public Buildings Evacuation Routes with Space Syntax Approach Case Study: The Design of Kanisius Junior High School, Kalasan
 
Fires and earthquakes are the two major disasters that threaten buildings. Public buildings require a design that can mitigate the adverse effects of the disaster, which requires excellent attention to the evacuation aspect when a disaster occurs. This study will evaluate the design of one of the public buildings that became the study material, Kanisius Junior High School (SMP), located in Kalasan, D.I. Yogyakarta. The building consists of 3 floors with an area per floor of 755 m2. It has a vertical emergency evacuation route through stairs at both ends. Using the Space Syntax method, the path design integration evaluation uses the Integrity tools in the Axial Map series. In contrast, the Visibility Graph tools are used to determine the level of visibility of the path and the ideal need for placing emergency exit signage. The result is that the level of integration of the evacuation route in the Kanisius Kalasan Junior High School building will be known, and the ideal signage placement will be recommended. This research is expected to contribute knowledge in the field of architecture related to the optimization method of emergency evacuation route design in multi-story buildings, as well as provide input for relevant stakeholders.
A new class of higher quantum Airy structures as modules of $\mathcal{W}(\mathfrak{gl}_r)$-algebras
Authors: Bouchard Vincent , Mastel Kieran
Published: June 2023

Quantum rr-Airy structures can be constructed as modules of \mathcal{W}(\mathfrak{gl}_r)𝒲(𝔤𝔩r)-algebras via restriction of twisted modules for the underlying Heisenberg algebra. In this paper we classify all such higher quantum Airy structures that arise from modules twisted by automorphisms of the Cartan subalgebra consisting of products of disjoint cycles of the same length. An interesting feature of these higher quantum Airy structures is that the dilaton shifts must be chosen carefully to satisfy a matrix invertibility condition, with a natural choice being roots of unity. We explore how these higher quantum Airy structures may provide a definition of the Chekhov, Eynard, and Orantin topological recursion for reducible algebraic spectral curves. We also study under which conditions quantum rr-Airy structures that come from modules twisted by arbitrary automorphisms can be extended to new quantum (r+1)(r+1)-Airy structures by appending a trivial one-cycle to the twist without changing the dilaton shifts.
Sifting composite from elementary models at FCCee and CePC
Authors: Cacciapaglia Giacomo , Deandrea Aldo , Iyer Abhishek , Pinto Andres
Published: June 2023

New Physics models with either an elementary or composite origin are often associated with a similar imprint in a direct search at colliders, case in point being the production of a light pseudoscalar in association with a monochromatic photon from the decay of a Z boson at future e+e-e+e− colliders. We exploit the correlation between the discovery of a signal in the Z decays and electroweak precision measurements as a tool to distinguish a composite model from an elementary scalar one. Our results offer an appealing and rich physics case for future colliders and demonstrate how a lepton collider at the Z mass can be a discovery machine for new physics in the Higgs sector.
On the effect of vibrational capture of rotation of an unbalanced rotor
Authors: Yaroshevich Nikolay , Grabovets Vitalij , Yaroshevich Тetjana , Pavlova Irina , Bandura Irina
Published: June 2023

The dynamics of an unbalanced rotor with a vibrating suspension axis and driven by an asynchronous electric motor of limited power is considered. Stationary (near stationary) modes of rotation of the rotor with a frequency equal to the vibration frequency of the axis are investigated. An explanation of the phenomenon of vibrational capture of rotation of an unbalanced rotor is given. The proposed mechanical interpretation of the effect allows deeper understanding of the classical results and conclusions. The obtained condition for the existence of a stationary mode allows us to estimate the frequency capture interval of the rotor. The case when the mode of vibration capture of rotation is not set is considered. For such a case, an expression for the vibrational moment is obtained, as well as an equation for slow motions. Attention is drawn to the possibility of occurrence in the considered modes of motion of slow (relative to the rotation frequency) rotor oscillations with sufficiently large amplitudes. It is demonstrated that the vibrational capture mode has the property of self-regulation; allows to stabilize the rotation frequency of an unbalanced rotor during load oscillations. Attention is drawn to the fact that in this mode of motion, there is certainly a transfer of energy either from the source of vibration to the rotor, or vice versa. The Sommerfeld effect in an oscillatory system with an inertial vibration exciter is represented by vibration capture of rotation of the vibration exciter by resonant oscillations of the carrier body. The theoretical results are confirmed by numerical modelling.
Applications of collaborative robots in agile manufacturing: a review
Authors: Kakade Siddhant , Patle Bhumeshwar , Umbarkar Ashish
Published: June 2023

Collaborative robots are machines that work hand in hand with humans; or as the name suggests, collaborate with them in a specific workspace. These robots are not enclosed in confined safety zones like traditional robots, as they interact very closely with humans. Though this is the case, appropriate measures are captivated while designing these robots considering human safety. These robots are well-versed in adapting to changes and frequent upgrades. They are flexible enough to carry out complex tasks. Due to these abilities, they become a significant asset in the manufacturing field. It’s been many years now since cobots are introduced in the industry sector. So, this is the right time to review various applications of cobots in manufacturing. First, the paper starts with a brief introduction followed by an extensive literature review which was structured after reviewing 76 research papers and articles. It ends with some essential conclusions. This paper discusses the diverse applications of cobots used in the manufacturing sector and their advantages. Further, it highlights the future of cobots and how they will be a boon for a technology-driven world.
An Overview: Synthesis of Menthol using Heterogeneous Catalysis
Authors: Tomar Ravi , Kundra Prapti , Sharma Juhi , Mohajer Fatemeh , Ziarani Ghodsi Mohammadi , Yadav Sangeeta
Published: June 2023

Essential oils are widely used in cosmetic and personal care products. These essential oils
such as menthol, limonene, rose oil, and jasmine oil are extracted from plants and also prepared in the
laboratory. Menthol is the most common cyclic monoterpene alcohol, which has been produced due
to its demand in various industries worldwide. In the literature, there were many protocols reported for
the synthesis of menthols from natural or synthetic precursors. In this review, we summarized the synthesis
of menthol from citral, citronellal, and pulegone using various heterogeneous catalysts under
different conditions. Considering the world’s demand for menthol in food preservatives and scents,
the right optimization of citronella extraction and its conversion is highly important. It can be used in
pharmaceutical industries due to the presence of active substances. The presence of flavored compounds
has the potential to enhance the nutritional value of food. This review will be very helpful for
researchers who are working on menthol synthesis in industry and institutions. The determination of
direct conversion to menthol over indirect conversion can be proven to be effective for industrial use
as it will be more economical and time-saving.
PENGARUH KONSENTRASI LARUTAN GARAM DAN LAMA SIMPAN TERHADAP MUTU TELUR BEBEK ASIN
Authors: Siti Shofiyati Siti Shofiyati , Siti Umniyatie Siti Umniyatie , Tutiek rahayu Tutiek Rahayu
Published: June 2023

Penelitian ini bertujuan untuk mengetahui konsentrasi larutan garam dan lama simpan berapa telur bebek asin masih memenuhi standar mutu telur asin. Penelitian ini merupakan penelitian eksperimen menggunakan 72 butir telur bebek yang di awetkan menggunakan larutan garam dengan konsentrasi 10%,20%, 30% dan 40%  dan direndam selama  10 hari, kemudian dikukus dan disimpan pada suhu ruang selama  10,  12  dan  14  hari  telur  bebek  asin  masing-masing  diambil  6  butir  secara  acak,  kemudian dilakukan uji mikrobilogi dan organoleptik untuk melihat mutu telur bebek asin. Data dianalisis secara deskriptif dengan melihat keberadaan bakteri patogen yaitu bakteri Salmonella sp. dan bakteri Staphylococcus aureus serta melihat sifat organoleptik seperti warna, bau, tekstur dan rasa pada telur bebek asin untuk menentukan kualitas mutu telur bebek asin menurut standart SNI. Hasil penelitian menunjukkan bahwa telur bebek asin dengan kombinasi perlakuan konsentrasi larutan garam dan lama simpan berdasarkan uji organoleptik dan uji bakteri patogen masih memenuhi syarat mutu telur asin. Sedangkan jumlah total bakteri pada telur bebek asin melebihi batas maksimum, dan sudah tidak sesuaidengan standar yang diperbolehkan yaitu 1x105  Cfu/ml. Telur bebek asin yang memiliki mutu palingbaik dari semua parameter seperti organoleptik, ada tidaknya bakteri patogen dan jumlah total bakteri didapatkan pada kombinasi perlakuan dengan konsentrasi larutan garam 40% dan lama simpan pada hari ke 12.  Kata kunci: Telur bebek asin, kualitas mikrobiologi dan organoleptik, Jumlah total bakteri
PENGARUH VARIASI KONSENTRASI PUPUK CAIR ORGANIK TERHADAP PERTUMBUHAN TANAMAN TERUNG DENGAN PEMAPARAN GELOMBANG SUARA
Authors: Dian Larasati Dian Larasati , Djukri Djukri , Budiwati Budiwati
Published: June 2023

Tujuan khusus penelitian untuk mengetahui konsentrasi pupuk cair organik yang optimal untuk pertumbuhan tanaman terung. Penelitian ini merupakan penelitian eksperimen yang dilakukan pada bulan Mei hingga September 2015. Penelitian dilakukan di lahan pekarangan yang terletak di Dusun Cabean RT 04 Jalan Parangtritis Km 7 Sewon Bantul Daerah Istimewa Yogyakarta. Populasi dalam penelitian ini adalah 150 bibit tanaman terung (Solanum melongena L.) varietas Antaboga dan sampel dalam penelitian ini adalah 20 tanaman yang diambil secara acak. Penelitian ini dilakukan dengan pemberian variasi konsentrasi pupuk yakni 0 cc/l (kontrol), 1 cc/l, 2 cc/l dan 3 cc/l pada tanaman yang terpapar suara garengpung termanipulasi pada frekuensi 4.500 Hz. Parameter yang diamati dalam penelitian ini meliputi luas bukaan stomata daun, aktivitas nitrat reduktase dan pertumbuhan (tinggi tanaman, jumlah daun (helai) serta produktivitas) tanaman terung (Solanum melongena L). Analisis penelitian menunjukkan bahwa pemberian pupuk cair organik dengan konsentrasi pupuk 0 cc/l, 1 cc/l, 2 cc/l dan 3 cc/l memberikan hasil yang berbeda tidak nyata atau tidak berpengaruh terhadap luas bukaan stomata, tinggi tanaman, jumlah daun (helai) dan aktivitas nitrat reduktase. Konsentrasi pupuk cair organik yang optimal pada pertumbuhan tanaman terung (Solanum melongena L.) yang terpapar gelombang suara garengpung termanipulasi pada frekuensi 4.500 Hz adalah 3 cc/l.   Kata kunci: terung, pertumbuhan, pupuk cair organik, gelombang suara
IDENTIFIKASI KERUSAKAN HISTOLOGIK HEPAR IKAN NILA (Oreocrhomis niloticus, L) KOLAM FAKULTATIF IPAL SEWON BANTUL
Authors: Sukiya Sukiya , Tri Harjana Tri Harjana
Published: June 2023

Penelitian eksplorasi ini dilakukan di Balai IPAL Sewon Bantul untuk mengetahui gejala tingkat sublethal ikan bioindikator air limbah kolam fakultatif pada jaringan hepar serta mengetahui jenis kerusakan struktur histologik hepar ikan nila yang terjadi. Populasi adalah ikan nila di kolam fakultatif Balai IPAL Sewon. Sampel berupa organ hepar dari tiga ekor ikan nila kolam fakultatif. Metode penelitian berupa identifikasi pengamatan penampang pada satu bidang pandang preparat yang di ambil menggunakan obtilab. Data penelitian merupakan data kualitatif dari pengambilan gambar histologik hepar tersebut. Hasil penelitian merupakan deskripsi hasil pengamatan histologik hepar ikan nila kolam fakultatif yang dibandingkan dengan histologik hepar ikan nila pada kolam tidak tercemar sebagai kontrol. Hasil penelitian menunjukkan hepar ikan nila mengalami gangguan sublethal akibat paparan air limbah kolam fakultatif, sedangkan hepar ikan nila kontrol tidak terdapat kerusakan. Kerusakan histologik hepar yang diidentifikasi adalah piknosis, karyoreksis, dan karyolisis. Kata Kunci: Ikan nila, air limbah dan gejala sublethal.
FENOLOGI PERKEMBANGAN BUNGA DAN POLINIA SPATHOGLOTTIS PLICATA BLUME
Authors: Mir’atun Suroya Mir’atun Suroya , Budiwati Budiwati , Ratnawati Rtanawati
Published: June 2023

Penelitian ini bertujuan untuk mengetahui fenologi perkembangan bunga dan polinia S. plicata Blume. Penelitian ini bersifat deskriptif eksploratif. Untuk mengetahui tiap tahap perkembangan bunga S. plicata Blume dilakukan pengamatan fase-fase perkembangan bunga dari fase inisiasi sampai antesis.Fenologi perkembangan bunga S.plicata Blume adalah sebagai berikut: (1) inisiasi awal, (2) inisiasi tengah tahap I (-39 s/d -36 HSA), (3) inisiasi tengah tahap II (-35 s/d -18 HSA), (4) inisiasi akhir (-17 s/d -10 HSA), (5) preantesis awal (-9 s/d -5 HSA), (6) preantesis akhir (-4 s/d -1 HSA), dan (6) antesis (HSA s/d +3 HSA). Sedangkan untuk mengetahui tahap perkembangan polinia, dilakukan pengamatan preparat berseri kuncup bunga dan ginostemium S.plicata Blume pada setiap fase.Perkembangan poliniaS.plicata Blume adalah sebagai berikut: (1) antera tersusun oleh sel meristematik homogen, (2) antera menunjukkan 2 teka, (3) mikrosporangium menunjukkan kumpulan sel induk mikrospora, (4) tahap metaphase I, (5) tahap sel diad, (6) tahap tetrad mikrospora, memperlihatkan tetrad isobilateral, tetrad decusate, dan tetrad tetrahedral. Kata kunci: fenologi, polinia, Spathoglottis plicata Blume
DAYA TETAS KOKON CACING TANAH(Lumbricus rubellus)DI BAWAH PENGARUH PEMBERIAN INSEKTISIDA ORGANOFOSFAT
Authors: Santosa Misbachun Aji , Ciptono Ciptono , Suhandoyo Suhandoyo
Published: June 2023

Penelitian ini bertujuan untuk mengetahui daya tetas kokon cacing tanah (Lumbricus rubellus) di bawah pengaruh pemberian insektisida organofosfat.Jenis penelitian adalah eksperimen satu faktor pola acak lengkap.Objek yang digunakan dalam penelitian adalah kokon cacing tanah Lumbricus rubellus.Penelitian dilakukan selama 30 hari.Penelitian terdiri dari 5 kelompok perlakuan, yaitu kontrol (tanpa pemberian insektisida), P1 (0,4gr/L), P2 (0,6gr/L), P3 (0,8gr/L), dan P4 (1gr/L).Pemberian perlakuan insektisida organofosfat pada kokon selama 2 menit.Variabel tergayut dalam penelitian ini adalah daya tetas kokon cacing tanah Lumbricusrubellus.Data hasil penelitian di analisis dengan One Way Anova untuk mengetahui ada tidaknya pengaruh insektisida terhadap daya tetas kokon Lumbricusrubellus. Hasil penelitian menunjukkan bahwa pemberian insektisida organofosfat sampai dengan dosis 1gr/L, pada kokon cacing tanah Lumbricus rubellus tidak memberikan pengaruh yang signifikan terhadap daya tetas kokon (P0,05). Kata kunci: Kokon, Lumbricus rubellus, insektisida orgsnofosfat.
Nilai Penting dan Kemerataan Plankton di Perairan Sungai Bedog
Authors: Hidayatun Rifa , Sudarsono Sudarsono , Sukiya Sukiya
Published: June 2023

Penelitian mengenai nilai penting dan kemerataan plankton di Sungai Bedog telah dilakukan pada bulan Februari 2016. Penelitian bertujuan untuk mengetahui jenis plankton, nilai penting tertinggi plankton, dan kemerataan plankton di perairan Sungai Bedog dari hulu (Desa Turi, Kabupaten Sleman) sampai hilir (Pantai Baru, Kabupaten Bantul).Penelitian ini merupakan penelitian deskriptif eksploratif dengan purposive sampel didasarkan pada perubahan penggunaan DAS Bedog dari hulu sampai hilir. Pengambilan sampel plankton dilakukan dengan mengambil sampel air sebanyak 50 liter kemudian menyaringnya  menggunakan planktonnet. Sampel diawetkan menggunakan gliserin dan diidentifikasi di laboratorium biologi menggunakan buku identifikasi Edmonson (1996) dan Needham and Needham (1973). Pengukuran kondisi fisika dan kimia lingkungan dilakukan pada setiap stasiun meliputi pengukuran suhu air, kuat arus, kekeruhan, pH, intensitas cahaya, salinitas, DO, BOD, nitrat, dan fosfat.Hasil penelitian diperoleh plankton yang terdapat di Sungai Bedog terdiri dari fitoplankton dan zooplankton. Fitoplankton yang ditemukan terdiri dari 4 kelas yaitu Bacillariophyceae (17 jenis), Chlorophyceae (10 jenis), Cyanophyceae (7 jenis), dan Conjugate (2 jenis). Zooplankton terdiri dari 6 kelas yaitu Rotifera (20 jenis), Sarcodina (2 jenis), Crustacea (2 jenis), Copepoda (3 jenis), Tubulinea (1 jenis), dan Lobosea (1 jenis). Tabelaria binalis adalah jenis dengan nilai penting tertinggi yaitu 90,12. Kelas Bacillariophyceae adalah kelas dengan nilai penting tertinggi yaitu 192,22. Nilai penting fitoplankton lebih tinggi dibandingkan nilai penting zooplankton yaitu 241,91 dan 58,09. Kemerataan fitoplankton cukup merata, sedangkan zooplankton kurang merata, dan plankton secara keseluruhan di Sungai Bedog adalah cukup merata. Kata kunci : plankton, identifikasi, nilai penting, kemerataan, Sungai Bedog
TOKSISITAS LIMBAH CAIR PABRIK BATIK TERHADAP KELANGSUNGAN HIDUP, STRUKTUR HISTOLOGIK GINJAL, DAN DAGING IKAN NILA (Oreochromis niloticus)
Authors: Mualifah Azzah , Sukiya Sukiya , Suhartini Suhartini
Published: June 2023

Industri batik di kota Yogyakarta sangat banyak, namun pengolahan limbahnya masih sederhana, sehingga perlu dilakukan uji toksisitas. Peneitian ini bertujuan untuk mengetahui pengaruh limbah cair pabrik batik terhadap kelangsungan hidup, struktur histologik ginjal, serta kandungan kromium pada daging ikan nila. Penelitian ini merupakan penelitian eksperimen yang dilakukan pada bulan November 2015- April 2016. Lokasi pengambilan sampel limbah cair pabrik batik di Imogiri Yogyakarta. Uji yang dilakukan yaitu uji pendahuluan, toksisitas, pengamatan struktur histologik ginjal ikan nila, pengukuran fisikokimia air, serta pengukuran kandungan kromium pada daging ikan nila. Limbah cair pabrik batik mempengaruhi kelangsungan hidup ikan nila dimana semakin tinggi kadar limbah cair pabrik batik semakin rendah tingkat kelangsungan hidup ikan nila serta mempengaruhi struktur histologik ginjal yang ditandai dengan adanya kerusakan berupa nekrosis, hipertropi pada sel tubulus, lumen menyempit, inti glomerulus mengalami piknosis, peradangan antar sel tubulus, sel terlepas dari glomerulus. Kandungan kromium pada daging ikan nila masih berada dalam ambang batas aman karena masih berada di bawah 2,5 mg/kg. Ambang  batas  yang  ditetapkan  oleh Dirjen POM No. 03725/ B/ SK/ 89. Kata kunci : ginjal, ikan nila, kelangsungan hidup, limbah batik, struktur histologik.
STRUKTUR KOMUNITAS PLANKTON DI WADUK PANDANDURE, NUSA TENGGARA BARAT
Authors: Mardani Riasari , Sudarsono Sudarsono , Suhartini Suhartini
Published: June 2023

Penelitian ini bertujuan untuk mengetahui kualitas fisik-kimia perairan waduk Pandandure, struktur komunitas plankton dan status ekosistem waduk Pandandure berdasarkan struktur komunitas plankton di Waduk Pandandure. Penelitian ini merupakan penelitian deskriptif dengan metode observasi, populasi penelitian adalah plankton yang ada di Waduk Pandandure dan sampel penelitian adalah plakton yang tersaring dalam planktonnet no.25 dari masing-masing stasiun. Stasiun pengambilan sampel terdiri dari 5 stasiun yaitu inlet, tepi kanan, tepi kiri, midlet dan outlet. Setiap stasiun dibagi menjadi 3 titik pengamatan dengan pengambilan sampel pada masing-masing titik adalah 3 kali. Faktor fisik-kimia yang diukur pada penelitian ini adalah suhu, kekeruhan, pH, DO, COD, BOD, nitrat, fosfat, dan amonia. Hasil penelitian menunjukkan bahwa di Waduk Pandandure memiliki kualitas perairan yang tercemar dilihat dari nilai DO dan BOD serta masuk dalam kategori perairan eutrofik dilihat dari pengukuran fosfatnya. Parameter fisika, berupa suhu 31-33 0C, kekeruhan 14,7 NTU sedangkan parameter kimia berupa pH 8,07-8,94, DO 3,57-1,03 mg/L, BOD 21,7-42,5 mg/L, COD 33,6-55,3 mg/L, nitrat 0,30 mg/L, fosfat 0,03-0,62 mg/L, dan amonia 1,04-1,73 mg/L. Perairan Waduk Pandandure memiliki 31 jenis plankton, yang terdiri dari 14 spesies fitoplankton dan 17 spesies zooplankton. Spesies fitoplankton yang teramati dari divisi Cyanobacteria, Dinoflagellata, Chlorophyta, Chromophyta, dan Bacillariophyta. Sedangkan zooplankton terdiri dari filum Rotifera, Arthropoda, Ciliophore dan Protozoa. Waduk Pandandure memiliki indeks nilai penting (INP) tinggi untuk divisi Cyanobacteria, 263,584 % dan filum Rotifera 248,941%. Indeks keanekaragaman fitoplankton, 0,018 – 0,068 masuk dalam kategori rendah dan indeks keanekaragaman zooplankton, 1,260-1,578 masuk dalam kategori sedang, rendahnya indeks keanekaragaman ini menunjukkan adanya dominasi dari fitoplankton yaitu kelompok Cyanobacteria. Oleh karenanya waduk Pandandure menunjukkan ekosistem yang tidak stabil. Kata kunci : Struktur Komunitas, Plankton, Waduk Pandandure