bluuebunny/crossref_metadata_2025 huggingface dataset:
SAPHO Syndrome: Difficulties of Diagnosis in the Clinical Case. Radiology Imaging
Authors:   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia, Prokhorov S.N. , Krylov A.S. ,   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia, Kuzin A.V. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Russia, Ryzhkov A.D. ,   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia,   Russian Medical Academy of Continuous Professional Education, Moscow, Russia, Kochergina N.V. ,   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia,   Russian Medical Academy of Continuous Professional Education, Moscow, Russia, Pronin A.I. ,   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia, Bludov A.B. ,   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia, Anikin S.G. ,   V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia
Published: May 2023

Purpose: Demonstrate the possible manifestations of SAPHO syndrome. Material and methods: 38-year-old woman with suspected SAPHO syndrome were performed scintigraphy and SPECT/CT for evaluate the localization and abundance of the process. Results: Osteosclerosis and hyperostosis of the left clavicle, osteosclerosis of the L1 vertebra and other, less pronounced changes, accompanied by active accumulation of the 99mTc-MDP, were revealed. Conclusion: It is important to remember the specific complex of symptoms of this nosological entity and the possible isolated onset of individual manifestations, which was also observed in our case.
Study on proximate composition and nutritional quality of some farm made fish feed collected from Muktagacha, Trishal and Phulpur upazila in Mymensingh district
Authors: Toppo Narayon , Rana Md Masud , Rahman Md Mamunur , Hossain Md Sazzad
Published: May 2023

An experiment was conducted to evaluate the feed quality of farm made feed from three upazila of Mymensingh district for four months from July to October, 2015. Fish feed samples were collected from various farms at Muktagacha, Phulpur and Trishal upazila of Mymensingh district. Total 30 feed samples were analyzed to determine the proximate composition and quality of farm made feed. Only one feed sample (F- 27) contains less than 12% moisture found in Trishal upazila. Maximum moisture value (24.53%) was found in feed sample F-13 in Phulpur upazila which indicated that this feed is poor quality compared to others. These may due to lack of maintenance at processing and may be due to improper storage system. Only four feeds were found having more than 25% protein. The analyzed crude protein contents of fish feed varied from 10.85 to 27.30%. The highest protein content was observed in feed (F-20) (27.30%) and the lowest was found in 10.85% in feed (F-22). The mean crude lipid values of the analyzed fish feeds varied from 5.79 to 22.95%. Highest lipid content was observed in 22.95% in feed (F-19). The analyzed mean ash content of fish feeds varied from 8.41 to 20.99%. The fiber content was observed within 4.35-8.20%. Ash content of feed (F-22) was found higher (20.99%) than other feeds. The analyzed nitrogen free extract (soluble carbohydrate) content of farm made fish feeds varied from 18.62 to 43.25%. The highest nitrogen free extract containing feed (F-25) having 43.25% NFE. The findings of this study demonstrated that low quality feeds and ingredients were supplied to the fish farmers by majority of feed traders and the farms with few exceptions were bound to use those ingredients due to their manufacture constraints.

Asian Australas. J. Biosci. Biotechnol. 2017, 2 (1), 1-8
Comparative efficacy of ivermectin (Vermic®), neem and trichlorfon (Negotox®) against humpsore in cattle
Authors: Talukder Milton , Sikder Subrata , Sarker Konica , Paul Ashit Kumar , Amin Mohammad Rohul
Published: May 2023

The experiment was conducted to evaluate the comparative efficacy of ivermectin, neem and trichlorfon against humpsore in cattle. A total of 2765 cattle from different villages of Barisal and Patuakhali district were selected for the diagnosis of humpsore. The prevalence of humpsore was found to be 7.52% in the southern part of Bangladesh. Out of humpsore infected cattle, twenty five (25) cattle between 2 - 7 years of age and irrespective of sexes  having typical lesion on hump and neck were selected for the experiment divided into five equals groups (A, B, C, D and E) and each group consists of 05 cattle. Group A kept as control group. Group B was treated with ivermectin (Vermic® @200 ug/kg body weight subcutaneously on 1th and 14th  day), group C with neem ointment (20%) topically twice daily for 25 days and group D with trichlorfon 10% (Negotox®) topically twice daily for 25 days and group E was treated with combined ointment (Neem + Trichlorfon 10%) topically twice daily for 25 days. On the basis of the reduction of sore lesions of cattle in all treated groups, the efficacy of ivermectin, neem, trichlorfon and combined ointment (Neem + Trichlorfon 10%) were found 100%, 57.78%, 64.16% and 82.07% at 28 days of post treatment respectively. The present findings demonstrated that ivermectin was much more effective than others therapeutic trials against humpsore in cattle.

Asian Australas. J. Biosci. Biotechnol. 2017, 2 (1), 68-74
Effect of growth regulators on in vitro multiplication of potato (Solanum tuberosum L.) cv. diamant
Authors: Shoyeb Md , Hossain Md Saddam , Islam Md Saiful , Azad Afifa , Sarkar Md Abdur Rauf , Rahman Shaikh Mizanur
Published: May 2023

Shoot tip and nodal segment explants from field grown plants were used as experimental materials in this investigation. All explants were cultured on MS medium supplemented with various plant growth regulators. For surface sterilization of explants, HgCl2 (0.1%) for 2 minutes was found to be most effective for complete killing of surface pathogens and getting healthy tissues. Shoot regeneration was observed from both shoot tips and nodal explants for the studied plant. Various concentrations of BAP (0.1, 0.2, 0.3mg/l) and GA3 (0.1, 0.2, 0.3mg/l) were used for shoot multiplication. In case of BAP, the highest length of shoot was recorded 4 cm and the highest percentage of shoot multiplication (73%) was noticed in MS+0.2mg/l BAP. And in case of GA3, the highest response for shoot multiplication (82%) was noticed in MS+ 0.1 mg/l GA3.But among all of the media formulations used in this experiment, the highest response for shoot multiplication (95%) within7-10 days was noticed in hormone free MS media. In case of root regeneration, the highest percentage (96%) of root induction was recorded in MS medium supplemented with no hormone.
Asian Australas. J. Biosci. Biotechnol. 2017, 2 (1), 81-88
Role of Intravenous Dexmedetomidine Premedication on Intra-operative Hemodynamics and PONV in Laparoscopic Cholecystectomy
Authors: Jabbar Abdul , Hasan M , Rahman M , Alam Shafiul , Tahsim Naima , Mondal Subrata Kumar
Published: May 2023

Background: Laparoscopic cholecystectomy is a gold standard surgical procedure for gallbladderoperation. It causes altered hemodynamic responses due to pneumoperitoneum and surgical procedurealso causes high incidence of postoperative nausea & vomiting (PONV). Dexmedetomidine has beenshown to reduce intraoperative hemodynamic instability and PONV.
Objective: This study was designed to evaluate the efficacy of intravenous dexmedetomidine premedicationfor attenuation of hemodynamic responses associated with pneumoperitoneum & its effect on postoperativenausea &vomiting.
Methods: Sixty adult patients of ASA physical status I & II scheduled for elective laparoscopiccholecystectomy were enlisted for a prospective randomized double blind study. They were selectedrandomized into two equal groups, thirty in each group. Group A received 0.9% normal saline 100 ml &Group B received dexmedetomidine (100μgm) in 100 ml 0.9% normal saline intravenously for 10 minutesbefore induction of anaesthesia. Pulse rate, mean arterial pressure were recorded prior to induction, 2minutes after endotracheal intubation, before pneumoperitoneum,10 minutes & 20 minutes afterpneumoperitoneum, 10 minutes after release of carbon dioxide(CO2) & 10 minutes after extubation. Inpost anaesthetic care unit patient were observed on 2,6,12,24 hour for PONV.
Results: Patients in Group B (dexmedetomidine) maintained greater hemodynamic stability compare toGroup A after intubation, during pneumoperitoneum and also extubation. Pulse rate & mean arterialpressure significantly varies in Group A compare with Group B at different times of intraoperative period(p <0.05). Postoperative nausea & vomiting was significantly less in Group B (dexmedetomidine).
Conclusion: Premedication with intravenous dexmedetomidine (100 μgm) attenuates the hemodynamicresponses produced by pneumoperitoneum during laparoscopic cholecystectomy and also significantlyreduces nausea and vomiting.
JBSA 2018; 31(1): 29-37
Medical Populism and the Moral Right to Healthcare
Authors: Mabaquiao Napoleon Jr. , Dacela Mark Anthony
Published: May 2023

Medical populism, as a political style of handling the challenges of a public health crisis, has primarily been analyzed in terms of its influence on the efficacy of governmental efforts to meet the challenges of the current pandemic (such as those related to testing, vaccination, and community restrictions). As these efforts have moral consequences (they, for instance, will affect people’s wellbeing and may lead to suffering, loss of opportunities, and unfair distributions), an analysis of the ethics of medical populism is much needed. In this essay, we address the need to analyze the moral dimension of medical populism by relating it to issues in healthcare ethics. Specifically, we identify the moral significance of medical populism by demonstrating how it contributes to the failure of governments to discharge their moral duty to provide for the healthcare needs of their people, and, correlatively, to the violation of the people’s moral right to healthcare. We argue that with medical populism, governments tend to mishandle the constraints that would morally justify their shortcomings in fulfilling such duty. We identify such constraints as mainly referring to the governments’ given (economic and institutional) capacities and the relative degree of incumbency of their competing duties.
PENGARUH MODEL PEMBELAJARAN INDUKTIF KATA BERGAMBAR TERHADAP HASIL BELAJAR SISWA
Authors: Bastika Ayu , Mujiburrahman Mujiburrahman
Published: May 2023

Pada pengamatan awal, guru Bahasa Inggris pada SD Integral Luqman Al-Hakim Mataram  seringkali  menggunakan  metode  konvensional  yaitu  metode  ceramah. Karena Bahasa Inggris adalah mata pelajaran yang membutuhkan partisipasi aktif siswa untuk mempelajarinya, maka metode ceramah yang lebih bersifat berpusat pada guru  tidak  tepat  untuk  digunakan.  Sering  kali  siswa  tidak  dapat  menangkap penjelasan guru. Kebanyakan siswa hanya mendengarkan dan mencatat  apa yang dijelaskan oleh guru sedangkan mereka tidak memahami materi pembelajaran itu sendiri. Rumusan masalah dalam penelitian ini adalah: Apakah Ada Pengaruh Model Pembelajaran Induktif Kata  Bergambar  terhadap  Hasil Belajar  Siswa Pada  Mata Pelajaran Bahasa Inggris Kelas V di SD Integral Luqman Al-Hakim Tahun Ajaran 2017/2018. Tujuan penelitian ini adalah: Untuk mengetahui Apakah Ada Pengaruh Model Pembelajaran Induktif Kata Bergambar terhadap Hasil Belajar Siswa Pada Mata Pelajaran Bahasa Inggris Kelas V Di SD Integral Luqman Al-Hakim Mataram Tahun Ajaran 2017/2018. Populasi dalam penelitian ini adalah siswa kelas V di SD Integral  Luqman  Al-Hakim  Mataram  yang  berjumlah  65  orang  siswa.  Karena populasi kurang dari 100 maka penelitian ini menggunakan studi populasi. Rancanagan penelitian menggunakan one-Group pretes-posttes design. Data dikumpulkan dengan menggunakan metode tes sebagai metode pokok sedangkan dokumentasi sebagai metode pelengkap. Tehnik analisis data menggunakan analisis statistik dengan rumus ttes. Hasil analisis diperoleh nilai ttest sebesar 5,170 dan nilai ttabel pada taraf signifikan 5% dengan db = N-1 = 25 lebih besar daripada nilai ttest pada tabel (5,170>2,060), berarti bahwa  ditolak dan Ha  diterima yang berbunyi: Ada Pengaruh Model Pembelajaran Induktif Kata  Bergamabar  terhadap  Hasil  Belajar Siswa Pada Mata Pelajaran Bahasa Inggris Kelas V Di SD Integral Luqman Al- Hakim Mataram Tahun Ajaran 2017/2018, sehingga dapat disimpulkan bahwa hasil penelitian ini “signifikan”. Kata Kunci: Model Pembelajaran Induktif Kata Bergambar, Hasil Belajar.
PERBANDINGAN STRATEGI THE POWER OF TWO DAN STRATEGI COOPERATIVE SCRIPT TERHADAP HASIL BELAJAR SISWA
Authors: Lita Lita , Tamba Wayan
Published: May 2023

Penelitian ini dilatarbelakangi oleh masih banyak guru yang menggunakan strategi pembelajaran monoton sehingga pada proses pembelajaran seringkali dijumpai adanya siswa yang kurang berpartisipasi aktif dalam mengikuti proses pembelajaran. Dalam mata pelajaran Pendidikan Agama Islam, strategi yang tepat pada dasarnya bertujuan untuk menciptakan kondisi pembelajaran yang memungkinkan siswa dapat belajar secara aktif dan bebas mengeluarkan pendapat mereka dalam pemecahan masalah sehingga dapat meraih hasil belajar yang optimal. Maka dalam hal ini strategi yang dapat digunakan adalah strategi the power of two dan cooperative script. Tujuan penelitian ini untuk mengetahui Perbedaan antara strategi pembelajaran The Power of Two dan strategi Cooperative Script Terhadap Hasil Belajar Siswa Kelas VIII Pada Mata Pelajaran Pendidikan Agama Islam di SMPN 2 Kopang Kabupaten Lombok Tengah Tahun Pelajaran 2016/2017. Populasi sebanyak 113 siswa dan sampel sebanyak 46 siswa. Jenis penelitian ini menggunakan penelitian eksperimen. Teknik pengumpulan data dalam penelitian ini menggunakan metode tes sebagai metode pokok dan dokumentasi sebagai metode pelengkap. Teknik analisis data menggunakan analisis statistik dengan rumus t-tes. Untuk membuktikan ada perbedaan hasil belajar siswa dilihat dari nilai (x₁) ̅ = 80,523 dan x ̅₂ = 73,043. Hasil analisis diperoleh nilai thitung sebesar 4,707 dan nilai ttabel pada taraf Signifikan 5% dengn d.b (N1-1)+(N2-1)= (23-1)+(23-1)= 22+22=44 lebih besar dari pada nilai t pada tabel (4,707 > 2,015), berarti Ho ditolak dan Ha diterima yang berbunyi: Ada Perbedaan Antara Strategi the power of two dan Strategi cooperative script Terhadap Hasil Belajar Siswa Kelas VIII Pada Mata Pelajaran Pendidikan Agama Islam di SMPN 2 Kopang Kabupaten Lombok Tengah Tahun Pelajaran 2016/2017, sehingga dapat disimpulkan bahwa hasil penellitian ini “signifikan”.Kata Kunci: Strategi The Power of Two, Cooperative Script, Hasil Belajar
Proximal to distal posture correction protocol for IT band friction syndrome in female amateur runners
Authors: Kadav Nayan , Bhende Radha , Shinde Sandeep
Published: May 2023

Iliotibial band friction syndrome is an overuse knee injury that is more common in runners. In IT band syndrome, pain, and tenderness are present over the lateral aspect of the knee. It is more common in females because of physiological and anatomical factors. The objective of this research was to determine and compare the effect of proximal to distal postural correction protocol with conventional physiotherapy program for IT band friction syndrome in female amateur runners. This study included 150 female amateur runners with IT band friction syndrome based on inclusion and exclusion criteria. Then the subjects were randomly allocated into group A and group B by simple random sampling method. Group A was given proximal to distal postural correction protocol and for group B conventional physiotherapy exercise program was given. Outcome measures used were a visual analog scale, postural assessment, tenderness assessment by palpation and Ober’s test. Pre and post-assessment of the above measures was taken to conform the results. The results showed a statistically significant effect of the proximal to distal postural correction protocol as compared to a conventional exercise program for IT band friction syndrome in female amateur runners. There was a significant reduction in pain (<0.0001) in individuals in group A than the group B. Postural abnormalities in IT band friction syndrome were also significantly (<0.0001) resolved and the Ober’s test came as 76% negative out of 100%positive patients. Based on results, it was concluded that the proximal to distal postural correction protocol is effective in female amateur runners.
Effects of the COVID-19 pandemic on daily life, mental health and coping strategies in a subpopulation of Brazilian adolescents
Authors: Rodrigues Roberta Neves Gago , Lemes Jéssica Alves , Souza Felipe Granado de , Tucci Adriana Marcassa , Viana Milena de Barros
Published: May 2023

The COVID-19 pandemic unprecedently impacted several aspects of people’s lives, including their mental health. Since adolescence confers vulnerability to mental health problems, this study aimed to analyze the impact of COVID-19 pandemic on daily life, mental health and coping strategies adopted by adolescents in Brazil and the correlation between these measurements. The study evaluated 215 adolescents from a Brazilian Middle and High school. A questionnaire to verify the impact of the pandemic on daily life aspects (academic activities, family/social interaction, and physical/mental health), the Depression, Anxiety and Stress Scale – Short Form (DASS-21), and the Coping Response Inventory – Youth Form (CRI-Y) were used. Results showed that the pandemic affected family/social interaction and physical/mental health aspects of life, in particularly among teenage girls. For this population, depression, anxiety and stress levels were also higher. A significant interaction between gender and educational stage was observed for the CRI-Y strategy “Acceptance or Resignation”, with girls, and in particularly older girls, punctuating more than boys. There was also a significant correlation between symptoms of depression, anxiety and stress and the following coping strategies: “Logical Analysis”, “Cognitive Avoidance”, “Acceptance-Resignation”, and “Emotional Discharge”. Results suggest that the pandemic significantly impacted different aspects of daily life and contributed to the increases in levels of depression, anxiety and stress in female adolescents and to the preferential use of maladaptive coping. These results highlight the urgent need for the development of effective intervention strategies, directed to stress coping, to mitigate the negative effects of COVID-19 in adolescents.
Ecofisiologia da soja em resposta a diferentes épocas de semeadura e densidades de cultivo
Authors: Peter Márcio , Dallmann Maicon Mascarello , Pedó Tiago , Aumonde Tiago Zanatta , Barbosa Benhur Schwartz , Medeiros Letícia Barão , Pimentel João Roberto
Published: May 2023

A soja (Glycine max (L.) Merril) é uma das culturas mais importantes do Brasil, sendo cultivada na maior parte do território brasileiro. O objetivo do estudo foi avaliar a ecofisiologia de plantas de soja em resposta a densidades de cultivo e épocas de semeadura. O delineamento experimental utilizado foi o de blocos casualizados em esquema fatorial com duas épocas de semeadura, ou seja, 15 de novembro e 14 de dezembro de 2018 e com cinco densidades de plantas (160, 200, 240, 280 e 320 mil plantas por hectare), com quatro repetições. Os caracteres avaliados foram: clorofila “a” e “b”, índice de área foliar, matéria seca de raiz, matéria seca de caule, matéria seca de folha, matéria seca de vagens, número de vagens por planta, altura no estádio R1, número de nós reprodutivos e rendimento por planta. A soja cultivada na segunda quinzena de novembro favorece maiores teores de clorofila nas folhas, maior acúmulo de matéria seca nas raízes, caules e folhas, bem como maior produtividade. Não houve correlações significativas entre índice de área foliar e altura de planta em estágio R1, com o índice de produtividade. O cultivo da soja em menores densidades favorece maior número de nós reprodutivos, número de legumes e produtividade por planta expressando a plasticidade fenotípica da cultura.
Parenting stress and interactive engagement behaviors in children with developmental delay
Authors: Yeom Jung Sook , Kim Rock Bum , Cho Jae Young , Park Ji Sook , Park Eun Sil , Seo Ji-Hyun , Lim Jae-Young , Woo Hyang-Ok
Published: May 2023

Background: In clinical practice, the importance of interactive engagement behaviors is overlooked in children with developmental problems other than autism spectrum disorder (ASD). Parenting stress affects children’s development but lacks attention from clinicians.Purpose: This study aimed to identify the characteristics of interactive engagement behaviors and parenting stress among non-ASD children with developmental delays (DDs). We also analyzed whether engagement behaviors affect parenting stress.Methods: At Gyeongsang National University Hospital, between May 2021 and October 2021, we retrospectively enrolled 51 consecutive patients diagnosed with DDs in language or cognition (but not ASD) in the delayed group and 24 typically developing children in the control group. The Korean version of the Parenting Stress Index-4 and Child Interactive Behavior Test were used to assess the participants.Results: The median age of the delayed group was 31.0 months (interquartile range, 25.0–35.5 months); this group included 42 boys (82.4%). There were no intergroup differences in child age, child sex, parental age, parental educational background, mother’s employment status, or marital status. Higher parenting stress (P<0.001) and fewer interactive engagement behaviors (P<0.001) were observed in the delayed group. Low parental acceptance and competence had the largest effects on total parenting stress in the delayed group. A mediation analysis revealed that DDs did not directly affect total parenting stress (β=3.49, P=0.440). Instead, DDs contributed to total parenting stress, which was mediated by children’s overall interactive engagement behaviors (β=57.30, P<0.001).Conclusion: Interactive engagement behaviors were significantly reduced in non-ASD children with DDs and significantly mediated parenting stress. The importance of parenting stress and interactive behaviors in children with DDs should be further examined in clinical practice.
The evolving role of lenvatinib at the new era of first-line hepatocellular carcinoma treatment
Authors: Chan Landon L. , Chan Stephen L.
Published: May 2023

Emergence of multi-targeted kinase inhibitors (MTIs) and immune checkpoint inhibitors (ICI) have changed the landscape of management in hepatocellular carcinoma (HCC). Combination therapy involving ICI has superseded sorafenib as the first-line treatment option for advanced HCC due to their superior response rates and survival benefits based on recently published phase III trials. However, the role of first-line lenvatinib remains uncertain as no prospective trials have compared its efficacy with ICI in advanced HCC. Several retrospective studies have shown that first-line lenvatinib may not be inferior to ICI combination. Indeed, a growing body of evidence suggests that ICI treatment is associated with inferior treatment outcome in non-viral HCC patients, questioning the supremacy of ICI treatment in all patients and rendering first-line lenvatinib as a potential preferred treatment option. Furthermore, in high-burden intermediate-stage HCC, accumulating evidence supports first-line lenvatinib, or in combination with transarterial chemoembolization (TACE), as a preferred treatment option over TACE alone. In this Review, we describe the latest evidence surrounding the evolving role of first-line lenvatinib in HCC.
Different activation of ACTH and corticosterone release in response to various stressors in rats.
Authors: Djordjević J , Cvijić G , Davidović V
Published: May 2023

The aim of this study was to investigate the reaction of the hypothalamo-pituitary-adrenocortical (HPA) system to various stressors (fasting, crowding, cold and heat) by measuring blood ACTH and corticosterone (CORT) concentration as well as the cholesterol (CHOL) content in the adrenals. To examine the effects of stress termination, the rats were returned and kept under control conditions for the same period as that of stress duration (supposed recovery period). According to our results HPA system was activated by all the stressors applied. Heat seems to be the strongest stressor since the exposure of animals to a high ambient temperature resulted in the greatest rise of plasma ACTH concentration as well as CORT synthesis and secretion. These values remained elevated after the stress termination i.e. after the rats had been returned to room temperature. Fasting seems to be the weakest stressor given because it causes the smallest increase in blood ACTH and CORT concentrations. Moreover, in refed rats the HPA function was fully recovered. In conclusion, the various stressors applied seem to induce a different response of the HPA system as judged by quantitative changes in ACTH and CORT release.
Leptin levels in obese children: effects of gender, weight reduction, and androgens.
Authors: Pilcová R , Šulcová J , Hill M , Bláha P , Lisá L
Published: May 2023

Obesity in children is accompanied by increased circulating leptin concentrations. Girls have higher leptin concentrations than boys. The aim of our study was to compare serum leptin levels before and after a five-week weight reduction program and to study the relationship of leptin levels, serum total cholesterol, and androgens (testosterone, dehydroepiandrosterone, dehydroepiandrosterone sulphate) in 33 obese boys (age: 12.7+/-1.97 years, BMI: 30.46+/-4.54) and 66 obese girls (age: 12.7+/-2.51 years, BMI: 29.31+/-4.62). We found that serum leptin concentrations in obese children were significantly decreased after a weight reduction program (before 20.79+/-9.61 ng/ml, after 13.50+/-8.65 ng/ml in girls; before 12.25+/-10.09 ng/ml and after 5.18+/-3.56 ng/ml in boys, p<0.0001 in both genders). Leptin levels correlated positively with the body mass index before and after weight reduction. There was a positive association in obese boys and a negative one in obese girls between leptin levels and the WHR (waist to hip circumference ratio). Serum leptin also shows a strong relationship to fat distribution (p=0.02 in boys, p<0.0001 in girls). No significant correlation was found between leptin concentrations and total cholesterol or androgens. We confirmed that leptin is a sensitive parameter of body composition and weight reduction in obese children.
Multimodality Imaging Evaluation of a Unilateral Madelung Deformity
Authors:   Resident, Department of Radiology, University of the Philippines -Philippine General Hospital., Jan David Cyruz , Marie Sydiongco-Inocencio Paula ,   Attending, Department of Radiology, University of the Philippines -Philippine General Hospital
Published: May 2023

A Filipino female teenager with gross deformity of her right wrist, came as an outpatient for radiographic evaluation nonspecific pain and numbness after prolonged repetitive, active wrist movements like writing and clapping, are noted with no history of trauma, infection, or surgical intervention of the aforementioned wrist.
Prevalence of Carbapenem-Resistant Enterobacteriaceae and the Genes Responsible for Carbapenemase Production in a Tertiary Care Hospital in South India
Authors: Joshi Devesh N. , Shenoy Bhaskar , MV Bhavana , Adhikary Ranjeeta , Shamarao Shivkumar , Mahalingam Archana
Published: May 2023

Introduction: Carbapenem resistance in Gram-negative bacilli (GNB) is a major concern in the management of resistant infections. The mechanism of carbapenem resistance is most commonly mediated by carbapenemases. The five most common genes (NDM, KPC, VIM, OXA, and IMP) are responsible for carbapenemase production. Knowledge of these genes is important for the management of the disease.

Objective: To estimate the prevalence of different genes responsible for carbapenemase production in GNB at a tertiary healthcare centre in South India.

Method: In this retrospective study, samples were collected over 16 months. Carbapenem-resistant GNB underwent to Xpert Carba-R assay (Cepheid, Sunnyvale, California, USA) for the detection of five important genes responsible for carbapenemase production: NDM, KPC, VIM, OXA, and IMP.

Results: Out of 184 carbapenem-resistant GNB, 20 samples were not included in this study. The rest of the 164 samples grew Klebsiella pneumoniae (152), Escherichia coli (10), and Enterobacter (2). OXA-48 and NDM were the most common genes responsible, with 137 (84.5%) and 95 (58.6%), respectively. Among them, 70 (43.2%) showed the presence of both genes, and 1 (0.6%) showed the presence of OXA-48, NDM, and VIM. Individually, 66 (40.7%) of OXA-48, 24 (14.8%) of NDM, and one (0.6%) of VIM. In this study, the authors did not find the presence of IMP or KPC genes.

Conclusion: As a result of limited options and the higher cost of antibiotics for carbapenem-resistant infections, knowledge of these genes helps in the selection and rational use of antibiotics reduces the cost of management and will prevent mortality and morbidity from these infections.
Improving students' creative thinking ability through problem-based learning in class VII SMP Negeri 24, Bengkulu City
Authors: Astria Ririn , Haji Saleh , Sumardi Hari , Audaya Robiatul
Published: May 2023

This study aims to describe how the application of the problem-based learning model can improve the creative thinking skills of class VII B students at SMP Negeri 24 Bengkulu City. The type of research in this research is Classroom Action Research or commonly called PTK. With data collection techniques using mathematical creative thinking ability tests. The subjects in this study were students of class VII B at SMP Negeri 24 Bengkulu City. The data analysis technique in this study is to calculate student learning outcomes at the end of each cycle. The results of this study indicate that there is an increase in evaluation tests in each cycle. In cycle I, the average student test score was sixty-seven with a classical pass of 50%. In cycle II there was an increase in the average score to 82.9 with a classical passing of 100% and an increase in the percentage of mathematical creative thinking, namely 52.66% (quite creative) in cycle I then in cycle II it increased to 86.77% (creative).
Editoriale
Authors: Sbaragli Silvia
Published: May 2023

La rivista Didattica della matematica. Dalla ricerca alle pratiche d’aula giunge al tredicesimo numero, il primo dell’anno 2023. Inaugura così il suo settimo anno di vita all’interno del Centro competenze didattica della matematica del Dipartimento formazione e apprendimento della SUPSI. Centro che si propone di promuovere e diffondere ricerche, riflessioni, progetti, pratiche, votati all’approfondimento dei numerosi aspetti che compongono la complessa e affascinante disciplina della didattica della matematica. Continua a leggere...
Türkiye’de Sosyal Girişimcilik Konulu Lisansüstü Çalışmalar Üzerine Bir İnceleme
Authors: Tuna Abdullah Sabit
Published: May 2023

Sosyal girişimcilik alanı hem dünyada hem de Türkiye’de gelişmeye devam etmektedir. Tüm dünyayı etkisine alan pandemi sürecinde yaşanan zorluklar, insanların siyasi ve ekonomik yapı başta olmak üzere, hayat tarzlarını, çalışma kültürlerini sorgulamaya sebep olmuş, aynı zamanda yeni arayışları da beraberinde getirmiştir. Bu arayışların sosyal faydaya odaklanan ve ekonomik faaliyetler yürüterek sürdürülebilir yapılar kurmaya çalışan; tüm süreçlerinde iş birliğini, adaleti ve şeffaflığı gözetmesi beklenen sosyal girişimciliğe olan ilgiyi daha da artırdığı ifade edilebilir. Bu çalışma, sosyal girişimciliğe yönelik artan ilginin lisansüstü çalışmalardaki izdüşümünü görebilmek ve hangi konularda çalışmalara ihtiyaç olduğunu ortaya koyabilmek amacıyla hazırlanmıştır. Bu amaç doğrultusunda, Türkiye’de sosyal girişimcilik alanında yapılan lisansüstü çalışmaların tespit edilerek derlenmesi, çalışmaların incelenmesi ve konuyu hangi boyutlarıyla ele aldıkları anlaşılmaya çalışılmıştır. Araştırma verileri YÖK Tez veri tabanında yer alan ve 2021 yılına kadar olan lisansüstü çalışmalardan elde edilmiştir. Arama, tasnif ve düzenleme sonrasında tespit edilen lisansüstü çalışmaların sayısı 73’tür. Bunların 15’i doktora tezi, 58’i ise yüksek lisans tezidir. Farklı disiplinler altında yapılan çalışmalarda, sosyal girişimciliğin kavram, mevzuat, sosyal girişimci profilleri, sosyal girişimcilik algı ve yönelimleri, yoksulluğun azaltılması ve farklı dezavantajlı gruplar bağlamında ele alındığı görülmüştür.
Pelatihan Publikasi Ilmiah Guru-guru Kota Tangerang Selatan pada Jurnal Investigasi SMP Negeri 17 Vol. 4, No. 1, Maret 2023
Authors: Kusjono Gatot , Suprianto Suprianto , Syamruddin Syamruddin
Published: May 2023

Community service activities Training on Scientific Publications of South Tangerang City Teachers in the Investigation Journal Volume 4 No.1 SMP Negeri 17 aims to assist elementary and junior high school teachers in South Tangerang City in writing scientific manuscripts that will be published in ISSN journals. The training method is carried out using the method of mentoring, discussion, workshop and technical guidance (bimtek) writing scientific manuscripts in accordance with journal manuscript standards. The training results obtained as many as 8 elementary school teacher manuscripts (67%) and 4 junior high school teacher manuscripts (33%). The publication of teacher scientific manuscripts in the Journal Investigative Volume 4 Number 1 March 2023, is very helpful for teachers in improving the quality of scientific manuscript writing and is very helpful in raising groups.
Portraits of the Loire in the Renaissance
Authors: Gebauer Imola
Published: May 2023

The Loire forms a key link for the Centre-Val-de-Loire and Pays-de-la-Loire Regions and for their inhabitants alike. It is unquestionably a geographic link, but also one which stems from the territory's long-standing history. This is the focus of the current project's aspirations through six animated films (4-5 minutes). To talk about the way in which the Loire's riverside territories relate to the river and about how this relation has its roots in a historical process involving the shaping of a landscape. The aim is to help the general public to picture what the Loire and its banks might have looked like in Renaissance times, and in doing so to grasp the ever-present nature of a relationship with the river forged slowly and patiently over time, which also shows that today's landscapes are a foundation for the landscapes of tomorrow.
Communicating the needs of a sector in times of crisis: European cultural networks, advocacy and forward-looking cultural policies
Authors: Magkou Matina
Published: May 2023

European cultural networks have been key actors in the European cultural sphere, but their advocacy potential has not been substantially documented. The Covid-19 crisis presented a unique moment for cultural networks to voice the needs of a sector, underline its value and contribute actively in forward looking cultural policies. In times where trust arises as a way to look forward, cultural networks provide the plat through a transnational perspective. The article examines the work of the European cultural networks from the early days of the pandemic until today through the advocacy lenses. Rather than providing an analysis of the main issues raised, the aim of the paper is to capture a moment in time that given its fluidity is in a constant evolution and make a contribution to understanding European cultural networks as transnational advocacy actors and rightful participants in the shaping of forward-looking cultural policies.
Problematic issues in constructing the common space of “knowledge societies”: resources of international cooperation in the field of culture
Authors: Zhyvohliadova Daryna
Published: May 2023

The article is devoted to the analysis of problematic issues of strategic lines’ realization within the international cultural policy and management. New challenges of modern realities of coexistence require a change in the usual established format of policy in the field of culture, creativity of its semantic and instrumental capital, in particular a new view on the discourse of international management in the field of culture. International cultural cooperation is considered as a constructed and organized knowledge exchange process and experience of sharing this knowledge. In this context, cultural management is a fundamental organizational and practical component of the universalization of the new accumulated knowledge about the experience of harmonization between global and local. The article raises questions concerning the effectiveness of methods and mechanisms of knowledge transfer, the search for resources of international cultural cooperation for the creation, accumulation and sustainable development of joint cultural capital.
Developing local cultural networks: the case of Dante 2021 in Ravenna
Authors: Patuelli Alessia , Donato Fabio
Published: May 2023

In the last decades and especially after the latest financial crisis, scholars are suggesting collaborative processes to address the reduction of public funds, as first discussed by New Public Management literature and later emphasised by Public Governance theories. As cultural activities belong to the wider set of public services, this paper enters the debate on delivering public services. It is aimed at analysing which factors contribute to an effective development of local cultural networks, also considering advantages, criticalities and potential for their future strengthening. Starting from a theoretical analysis, the paper carries out a case study of a local cultural network. The research focuses on the case of Ravenna, a town in northern Italy, and it is based on document analysis and semi-structured interviews. Results indicate that factors as geographic proximity, social relationships, a common cultural background and common values are crucial for the development of local cultural networks, consistently with isomorphism theory.
Brazilian cultural diplomacy in Europe in the early 21st century: bridging the gap between nations with international events
Authors: Boy Leonardo , Menezes Clarice
Published: May 2023

At the turn of the 21st century, Brazil gained ground within the international scene due to its new outward facing stance. Cultural plurality became the flagship of Brazilian foreign policy, designed to achieve positions of prestige internationally. By taking the theoretical concepts of cultural diplomacy, this case study analyses the strategies deployed in international events for cultural diffusion promoted by Lula da Silva’s (2003-2011) & Dilma Rousseff’s (2011-2016) administrations, especially the Year of Brazil in France, 2005. The policy processes within the Ministry of Foreign Affairs, Ministry of Education and the Ministry of Culture supported the emergence of a particular decision regarding the development of Brazilian cultural internationalisation. Therefore, the active role of Brazil in the field of cultural diplomacy could be considered as a benchmark for governments, practitioners and policymakers from 2003 to 2016.
Global hotspots and emerging trends in 3D bioprinting research
Authors: Ding Zhiyu , Tang Ning , Huang Junjie , Cao Xu , Wu Song
Published: May 2023

Three-dimensional (3D) bioprinting is an advanced tissue engineering technique that has received a lot of interest in the past years. We aimed to highlight the characteristics of articles on 3D bioprinting, especially in terms of research hotspots and focus. Publications related to 3D bioprinting from 2007 to 2022 were acquired from the Web of Science Core Collection database. We have used VOSviewer, CiteSpace, and R-bibliometrix to perform various analyses on 3,327 published articles. The number of annual publications is increasing globally, a trend expected to continue. The United States and China were the most productive countries with the closest cooperation and the most research and development investment funds in this field. Harvard Medical School and Tsinghua University are the top-ranked institutions in the United States and China, respectively. Dr. Anthony Atala and Dr. Ali Khademhosseini, the most productive researchers in 3D bioprinting, may provide cooperation opportunities for interested researchers. Tissue Engineering Part A contributed the largest publication number, while Frontiers in Bioengineering and Biotechnology was the most attractive journal with the most potential. As for the keywords in 3D bioprinting, Bio-ink, Hydrogels (especially GelMA and Gelatin), Scaffold (especially decellularized extracellular matrix), extrusion-based bioprinting, tissue engineering, and in vitro models (organoids particularly) are research hotspots analyzed in the current study. Specifically, the research topics “new bio-ink investigation,” “modification of extrusion-based bioprinting for cell viability and vascularization,” “application of 3D bioprinting in organoids and in vitro model” and “research in personalized and regenerative medicine” were predicted to be hotspots for future research.
Size-selective downstream processing of virus particles and non-enveloped virus-like particles
Authors: Hillebrandt Nils , Hubbuch Jürgen
Published: May 2023

Non-enveloped virus-like particles (VLPs) are versatile protein nanoparticles with great potential for biopharmaceutical applications. However, conventional protein downstream processing (DSP) and platform processes are often not easily applicable due to the large size of VLPs and virus particles (VPs) in general. The application of size-selective separation techniques offers to exploit the size difference between VPs and common host-cell impurities. Moreover, size-selective separation techniques offer the potential for wide applicability across different VPs. In this work, basic principles and applications of size-selective separation techniques are reviewed to highlight their potential in DSP of VPs. Finally, specific DSP steps for non-enveloped VLPs and their subunits are reviewed as well as the potential applications and benefits of size-selective separation techniques are shown.
Influence of the constitutive model in the damage distribution of buildings designed with an energy-based method
Authors: Donaire-Avila Jesus , Benavent-Climent Amadeo , Mollaioli Fabrizio
Published: May 2023

It is widely accepted in the seismic design of buildings a certain level of damage under moderate or severe seismic actions but preventing the damage concentration in them. On the other hand, the energy-based design methodology proposes an optimum strength distribution for designing the structure of the building aimed at achieving an approximated even distribution of the damage—energy dissipated by plastic deformations—under seismic actions. Different approaches for the optimum strength distribution have been proposed in both existing literature and standards. Most of them were formulated from the results obtained in non-linear numeric evaluations of elastic-perfectly plastic (EPP) structures, such as the findings proposed recently by the authors of this study. However, studies on the optimum strength distributions of reinforced concrete (RC) structures are scarce. The present study sheds light on this issue. Accordingly, the structures of four prototype buildings with 3, 6, 9, and 12 stories were designed through an energy-based method by using five approaches for the optimum strength distribution: those proposed by the authors and two others from the literature and standards. Then, different prototypes of the structures arose considering the different approaches for the optimum strength distribution, two soil classes (dense and medium dense), and two ductility levels (low and high). Such prototype structures were subjected to two sets of far-field ground motion records by using three different constitutive models for the shear force-interstory drift relationship: EPP, Clough model, and Modified Clough model. The first characterizes the steel structures and the rest are typical for RC structures. A complete analysis was carried out to obtain the distribution of damage for EPP and RC structures, their deviations with respect to the “ideal” even distribution of damage, and the possible damage concentration on specific stories. RC structures showed a higher dispersion for the distribution of damage than EPP structures although those designed with the optimum strength distributions proposed by the authors showed the lowest values in the order of those obtained with EPP structures designed with optimum strength distributions proposed in the literature.
Antipsychotic-induced bone loss: the role of dopamine, serotonin and adrenergic receptor signalling
Authors: Weerasinghe D. Kavindi , Hodge Jason M. , Pasco Julie A. , Samarasinghe Rasika M. , Azimi Manavi Behnaz , Williams Lana J.
Published: May 2023

Antipsychotics are commonly used in treating psychiatric disorders. These medications primarily target dopamine the serotonin receptors, they have some affinity to adrenergic, histamine, glutamate and muscarinic receptors. There is clinical evidence that antipsychotic use decreases BMD and increases fracture risk, with dopamine, serotonin and adrenergic receptor-signalling becoming an increasing area of focus where the presence of these receptors in osteoclasts and osteoblasts have been demonstrated. Osteoclasts and osteoblasts are the most important cells in the bone remodelling and the bone regeneration process where the activity of these cells determine the bone resorption and formation process in order to maintain healthy bone. However, an imbalance in osteoclast and osteoblast activity can lead to decreased BMD and increased fracture risk, which is also believed to be exacerbated by antipsychotics use. Therefore, the aim of this review is to provide an overview of the mechanisms of action of first, second and third generation antipsychotics and the expression profiles of dopamine, serotonin and adrenergic receptors during osteoclastogenesis and osteoblastogenesis.