bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan Website UMKM Desa Teniga dengan Laravel dan Vue.js
Authors: Rahman Fazlul , Samsudin Angga Radlisa , Islam Rohmatul , Sunardi Sunardi
Published: December 2024

Penelitian ini bertujuan untuk mengembangkan dan menguji efektivitas sebuah platform website yang dirancang khusus untuk mendukung pengembangan UMKM di Indonesia. Metode yang digunakan meliputi desain dan implementasi website berbasis e-commerce yang mengintegrasikan fitur manajemen produk, pembayaran digital, dan analitik performa untuk pemilik UMKM. Hasil dari penelitian ini menunjukkan bahwa penggunaan website ini meningkatkan visibilitas dan efisiensi operasional UMKM, dengan tercatatnya peningkatan 30% dalam penjualan bulanan serta 25% dalam pengurangan biaya operasional. Selain itu, website ini juga mempermudah UMKM untuk mengakses pasar global dan mempercepat proses transaksi. Kontribusi utama dari penelitian ini adalah pengembangan alat digital yang terjangkau dan mudah digunakan untuk UMKM, yang tidak hanya meningkatkan daya saing mereka di pasar lokal maupun internasional, tetapi juga memberikan kontribusi signifikan terhadap literatur mengenai transformasi digital UMKM di negara berkembang. Penelitian ini diharapkan dapat menjadi acuan bagi pengembangan platform serupa serta memberikan wawasan bagi kebijakan pemerintah dalam mendukung digitalisasi UMKM.
Social capital in Central Asia: how civil society shapes democracy in the region?
Authors: Saini Ayushi Saini
Published: December 2024

Networks and mutual trust have long been integral to the traditions of Central Asian peoples. The collective cultural practices among nomadic populations have historically served as crucial tools for their survival. Social capital has influenced various aspects of Central Asian society since the Soviet era. Despite the Sovietization of local communities, traditional social actors continued to exist. Since gaining independence in 1991, institutions of social capital have played an important role in shaping the governance processes of Central Asian states. Social capital embodies the concept of "rule from below", which is a fundamental component of democratization. However, in Central Asia, while social capital institutions are pre-democratic, they still uphold democratic values. Informal communication, evident in various forms across the region, remains one of the primary sources of social capital. These forms can serve as carriers of democratic values. However, it is also essential to recognize the existence of negative social capital, which can adversely affect individuals or specific social strata. This paper aims to emphasize the role of traditional civil society, which constitutes social capital, in fostering democratic values in these countries. Additionally, it will highlight the significance of informal social and historical practices as elements of neo-institutionalism in Central Asia. This study will utilize a literature review methodology complemented by the author's analytical approach to address research gaps and provide evidence-based insights.
Effects of Tisochrysis lutea on Dry Eye Symptoms
Authors: Kim Chae Won , Kim Hoon , Park Yu Yeon , Park Yuli , Cho Kyong Jin
Published: December 2024

Purpose: Tisochrysis lutea is a marine microalga known for its anticancer and antioxidant properties. This study aimed to investigate the efficacy and safety of T. lutea in adults with dry eye symptoms.Methods: One hundred participants with dry eye symptoms were enrolled and divided into two groups: one received T. lutea powder (test group), and the other received control food (placebo, control group) for 12 weeks. Subsequently, the measurements of ocular surface disease index (OSDI), tear secretion (Schirmer’s test), tear break-up time (TBUT), corneoconjunctival staining, and safety assessments were compared between the test and control groups.Results: In terms of the OSDI score, the value for the test group decreased by 6.51 points after 12 weeks of T. lutea powder intake, compared with baseline, whereas that in the control group decreased by 2.88 points, demonstrating a significant difference between the two groups (p = 0.002). The results of Schirmer's test also showed significant improvements: in the test group, the result for the right eye increased by 1.33 ± 3.71 after 12 weeks (p = 0.020), and that for the left eye increased by 1.93 ± 3.33 (p = 0.0003). However, no significant increases in the results were observed in the control group. Additionally, TBUT showed a significant increase from baseline in the right eye of the test group after 6 weeks of T. lutea powder intake (p = 0.043).Conclusions: After 12 weeks of consumption in the powdered form, T. lutea improved the symptoms of dry eye and increased tear production. Therefore, T. lutea can be used as an eye supplement for adults with dry eye symptoms.
Association between Age-Related Macular Degeneration and Arthritis: Data from the Korean National Health and Nutrition Examination Survey for 2017 and 2018
Authors: Nah Jun Sung , Mun Junho , Kim Kyoung Lae , Kim Yong-Kyu , Choi Youn Joo , Park Sung Pyo , Na Kyeong Ik
Published: December 2024

Purpose: We examined the association between age-related macular degeneration (AMD) and arthritis.Methods: Using data from the Korea National Health and Nutrition Examination Survey for 2017 and 2018, we conducted a complex sample analysis of 6,993 individuals with recorded information on AMD, as well as the diagnosis and treatment of osteoarthritis (OA) and rheumatoid arthritis (RA). We compared the diagnosis and treatment of arthritis between the AMD and control groups using logistic regression analysis, with a specific focus on the treatment among patients with arthritis.Results: In the AMD group (n = 1,118) and the control group (n = 5,875), univariate logistic regression analysis showed substantial differences in the diagnosis and treatment of OA and RA. However, after adjusting for age, alcohol consumption, diabetes mellitus, and hypertension in multivariate logistic regression analysis, these differences were no longer substantial. Among patients with OA (n = 246 in the AMD group and n = 821 in the control group), there was a significant association between AMD and OA treatments (odds ratio 1.511, 95% confidence interval 1.051-2.172).Conclusions: Patients diagnosed with and treated for OA had a higher likelihood of concurrent AMD than those who did not receive treatment. Therefore, ophthalmic examinations and closer monitoring are recommended for these patients.
A Case of Myelin Oligodendrocyte Glycoprotein Antibody-Positive Optic Neuritis
Authors: Lee Phil Kyu , Lee Seung Hoon , Ra Ho
Published: December 2024

Purpose: To report a case of optic neuritis associated with myelin oligodendrocyte glycoprotein (MOG) antibodies, treated with intravenous methylprednisolone pulse therapy.Case summary: A 40-year-old male patient with no underlying disease presented to clinic with sudden onset of bilateral blurry vision that began three days ago. He experienced severe headache and had history of bilateral refractive surgery. Best-corrected visual acuity measured right 0.06 and left 0.04. Relative afferent pupillary defect test was unremarkable, while Ishihara color vision test revealed inability to read any numbers in both eyes, except control plates. Although there were no limitations in extraocular movements, the patient reported pain in both eyes for all gaze movements. Widefield photograph and retinal nerve fiber layer image confirmed swelling of optic nerve head in both eyes. He was treated with high-dose intravenous methylprednisolone (1 g/day for 3 days). Magnetic resonance imaging demonstrated enhancement of the optic nerve sheaths in both eyes, and serum testing indicated positivity for MOG IgG antibodies. Three weeks later, visual acuity in both eyes improved to 1.0, and the color vision test showed correct identification of all 17 plates. Optic nerve head swelling in both eyes had resolved. However, optic neuritis recurred at 4, 6 weeks, and 3 months after the initial treatment, with each episode managed by high-dose intravenous methylprednisolone.Conclusions: This case shows early diagnosis and treatment of MOG antibody-associated optic neuritis can lead to improved visual outcomes. Appropriate serum testing for the diagnosis may be effective in patients with MOG antibody-associated optic neuritis.
The vibro annular abdominal vibration therapy improves sleep quality and life quality of insomnia patient A case report
Authors:   Department of Tuina, Affiliated Hospital of Changchun University of Chinese Medicine, China., De Yu Cong
Published: December 2024

Vibro-annular abdominal vibration is an effective treatment for insomnia. In this article, we report a case of vibro annular abdominal vibration therapy for insomnia in a male patient.
Treatment of drug induced erythema multiforme Case report
Authors:   Department of Oral Medicine and Radiology, Kothiwal Dental College and Research Centre, Moradabad, India., Murari Ambika
Published: December 2024

Erythema Multiforme EM is an acute condition driven by the immune system, featuring the rapid emergence of distinct target like lesions on the skin and mucous membranes.
Septic infection at the insulin pump injection site A case report
Authors:   Endocrinology and Metabolism Department, Yangpu District Shidong Hospital of Shanghai, No.999, Shiguang Road, Yangpu District, Shanghai, China., Huang Fang
Published: December 2024

Skin infections in diabetic patients are a complex pathologic process requiring high attention 1.
Organ morphogenesis proteins contribution in colorectal cancer
Authors:   Collegium Medicum, The Jan Kochanowski University in Kielce, Poland., Kozlowska Geller Monika
Published: December 2024

Colorectal Cancer CRC is the third most common cancer worldwide, with 1 2 million new cases diagnosed annually and the fourth leading cause of cancer related deaths.
Acute aortic regurgitation Physical examination and echocardiography
Authors:   Department of Cardiology, Matsushita Memorial Hospital, Osaka, Japan., Kawasaki Tatsuya
Published: December 2024

A 79 year old man presented with a 11 day history of dyspnea. His blood pressure was 149 61 mmHg, his pulse rate was 95 beats per minute, and his oxygen saturation level was 95% while breathing ambient air.
Interplay of malaria, thrombocytopenia, and HIV Co infection in a traveler returning from an endemic area A clinical case report
Authors:   Researcher, Internal Medicine, New York Medical College St. Clares St. Marys, New Jersey, USA., Sayyaparaju Mahith Varma
Published: December 2024

The co infection of malaria and HIV presents considerable diagnostic and treatment difficulties, especially in travellers returning from endemic areas.
Atypical presentation of primary adrenal lymphoma with adrenal insufficiency and hypercalcemia in an elderly male A diagnostic and therapeutic challenge
Authors:   Researcher, Internal Medicine, New York Medical College St. Clares St. Marys, New Jersey, USA., Sayyaparaju Mahith Varma
Published: December 2024

Primary Adrenal Lymphoma PAL is an exceedingly rare form of extra nodal lymphoma that mostly targets the adrenal glands, frequently manifesting with nonspecific symptoms that may result in a postponed diagnosis.
Management of challenging lower limb wounds with dermal matrixes A case series
Authors:   Department of Plastic, Reconstructive and Aesthetic Surgery, Tan Tock Seng Hospital, Singapore., EM Yeo Melissa
Published: December 2024

Lower limb wounds with exposed implants, tendons or extensive degloving with large soft tissue defects pose a significant challenge for the reconstructive surgeon.
AI-Powered Multimodal Disaster Response Enhancement using Social Media Streams
Authors: Rohini Temkar
Published: December 2024

Social media serves as a valuable source of real-time disaster data, providing timely updates that are critical for effective disaster monitoring and response. It plays an essential role in raising awareness, enhancing preparedness, and facilitating prompt action during emergencies. While much of the current research focuses on disaster prediction, real-time updates, which are key to saving lives and coordinating response efforts, are often overlooked. Our project addresses this gap by focusing on the collection and analysis of real-time data from various social media platforms, including disaster-related images and textual data like tweets.We use multiple APIs to gather real-time data from platforms such as Instagram, Facebook, and Twitter. To analyze visual data, we employ state-of-the-art multimodal models like ResNet50 and EfficientNet for image classification. For the textual data, advanced natural language processing models like BERT and XLNet are used for sentiment analysis, event detection, and severity assessment. By integrating and fusing the image and text data, our system is able to identify the type of disaster, estimate its severity, and provide actionable insights.
State of the art of scientific research in the field of self-healing concrete
Authors: Nizina Tatyana , Kovshov Artem
Published: December 2024

The paper presents the basic principles of obtaining self-healing concrete. The authors give the main scientific research trends in the field of increasing the durability of concrete with the introduction of biological additives - bacteria of limestone producers. The paper shows the principles of self-healing of cracks in concrete stone using microorganisms. The paper discusses the international and Russian experience of development implementation in the field of self-healing materials based on binders.
Blockchain-enhanced financial transparency: A conceptual approach to reporting and compliance
Authors: Titilope Tosin Adewale  , Titilayo Deborah Olorunyomi  , Theodore Narku Odonkor
Published: December 2024

The increasing demand for financial transparency and compliance has driven the adoption of innovative technologies to improve reporting systems. This paper proposes a conceptual framework for blockchain-enhanced financial transparency, emphasizing its transformative potential in ensuring accountability, accuracy, and regulatory compliance. Blockchain technology, with its decentralized, immutable, and secure ledger system, offers significant advantages in addressing challenges associated with traditional financial reporting and compliance mechanisms. The proposed framework focuses on integrating blockchain into financial reporting processes to create a tamper-proof environment for data management and transaction validation. Key components include real-time data sharing, automated compliance checks through smart contracts, and enhanced traceability of financial transactions. These features reduce the risks of fraud, errors, and misreporting while increasing stakeholders’ trust in financial disclosures. Additionally, the immutable nature of blockchain ensures an accurate historical record of financial activities, facilitating seamless audits and regulatory reviews. The research also explores the potential for interoperability between blockchain platforms and existing financial systems, enabling seamless integration without disrupting organizational workflows. The use of tokenization for asset representation and reporting simplification is examined, alongside strategies for ensuring scalability and efficiency in blockchain networks. Furthermore, the study highlights the role of artificial intelligence (AI) in analyzing blockchain-stored data to provide actionable insights and enhance decision-making. Challenges such as regulatory uncertainties, technological adoption barriers, and data privacy concerns are critically analyzed. Proposed solutions include developing industry standards, fostering regulatory collaborations, and adopting hybrid blockchain models to balance transparency with confidentiality. The study concludes that blockchain-enhanced financial transparency offers a robust framework for transforming financial reporting and compliance practices. It underscores the need for cross-industry collaboration and strategic investment to harness blockchain’s full potential in creating a secure and transparent financial ecosystem.
Fonksiyonel Gıda Üretiminde Yeni Yaklaşımlar
Authors: Kara Osman Onur
Published: December 2024

Fonksiyonel gıdalar, uluslararası kabul görmüş ortak bir tanımı olmamakla birlikte genel olarak temel beslenmenin ötesinde sağlık faydaları sağlayan ve normal diyetin bir parçası olarak tüketilen gıdalar olarak tanımlanmaktadır. Bu gıdalar, sahip oldukları olumlu etkileri, içerdikleri fenolik bileşikler, karotenoidler, fitosteroller, diyetsel lif, çoklu doymamış yağ asitleri, probiyotikler, A, C ve E vitaminleri gibi biyoaktif fonksiyonel bileşenler ya da etmenler sayesinde sağlarlar. Günümüzde artan tüketici bilinci ve sağlıklı beslenmenin önemini ortaya koyan bilimsel veriler fonksiyonel gıdalara olan ilginin de artışına yol açmıştır. Özellikle gıda teknolojisindeki gelişmelerle birlikte fonksiyonel gıdaların üretimi önemli düzeyde artmış ve yeni fonksiyonel gıda üretim metotları ve yaklaşımlarının oluşturulması konularındaki bilimsel ve endüstriyel çalışmalar da hız kazanmıştır. Bu çalışmada yakın zamanda fonksiyonel gıda üretimi ile ilgili yapılan yeni çalışmalarda yoğun olarak kullanılan metot ve yaklaşımlarla, ortaya çıkışı yeni olan fonksiyonel gıda üretiminde umut vadeden metot ve yaklaşımlar incelenmiştir. Bu kapsamda; 3 boyutlu (3D) yazıcı teknolojisi, vakumlu emdirme, nutrigenomik, tarımsal yan ürünlerin farklı yollarla fonksiyonel gıdalara işlenmesi ve tersine mühendislik yöntem ve yaklaşımlarının, fonksiyonel gıda üretiminde kullanımları açısından literatürde bu konudaki veriler dikkate alınarak incelenmesi ve değerlendirilmesi amaçlanmıştır.
A Macroanatomical Study on the Muscles of the Shoulder and Elbow Joint in the Anatolian Bobcat (Lynx Lynx)
Authors: Arı Hasan Hüseyin
Published: December 2024

This study was performed on their tendons and the muscles of the shoulder and the elbow joint in the two Anatolian bobcats. To achieve the objective, dissection and radiography techniques were applied to two dead materials. In this study, it is observed that the muscles connecting the forelimb to the trunk are composed of the rhomboid and the trapezius muscles called the dorsal group, and consist of the omotransverse, the brachiocephalic, the ventral serrate, superficial and deep pectoral muscles, and the broadest muscle of the back called the ventral group. Although the biceps and triceps of the forearm act on both the shoulder and elbow joints, it has been seen that the deltoid, infraspinous, supraspinous, subscapular and coracobrachial muscles take action on the shoulder joint and the brachial, anconeal muscles move the elbow joint in the Anatolian bobcat. In additional , it has been found that the rhomboid muscle has a cephalic head, the deep pectoral muscle are composed of the cranial, caudal and abdominal portions, the venter of the biceps muscle of the forearm are made by two distinct bellies, the triceps muscle of the forearm belongs distinct five heads in this research. The shoulder and elbow joints suggest that they may play an important role in the adaptation of the Anatolian bobcat not only in the movement but also in the hunting.
Suyun İncisi: Havyar
Authors: Fidan Yaren , Taşçı Fulya
Published: December 2024

Havyar, balık yumurtalıklarının bağ dokusundan ayrılarak tuzlama yapılan, katkı maddeleri ilave edilen ve bazen de muhafaza edilmesi amacıyla pastörizasyona tabi tutulan balık yumurtalarından elde edilmektedir. En değerli havyar Acipenseridae (mersin balığı) ailesine ait balık yumurtalarının gıdaya uygun tuzla işlenmesiyle üretilmiştir. Antik Mısır’dan Roma İmparatorluk'larına kadar birçok medeniyet havyarı lüks ve prestijin bir sembolü olarak görmüştür. Havyar içerdiği yüksek protein, çoklu doymamış yağ asitleri, vitamin ve mineralleri sayesinde insan sağlığı üzerinde olumlu etkileri bulunan besin değeri yüksek ve ekonomik açıdan değerli bir üründür. Bu nedenle, havyara talep gün geçtikçe artmış, dünya mutfağında önemli bir gıda ürünü haline gelmiştir. Günümüzde mersin balığı doğal popülasyonlarının azalmasını önlemek amacıyla havyar üretimi tamamen su ürünleri yetiştiriciliğiyle yapılmaktadır. İnsan sağlığına yönelik olası tehlikeleri ortadan kaldırabilmek veya en aza indirebilmek için havyarın üretim sürecini analiz etmek büyük önem taşımaktadır. Havyarın muhafazası; tuzlama, pastörizasyon ve soğuk depolama kombinasyonlarının kullanılmasıyla sağlanmaktadır. Bu makalede havyarın tarihçesi, bileşimi, üretimi, kalitesi, mikrobiyolojisi ve muhafazasını içeren konular hakkında kapsamlı bilgilere yer verilmiştir.
Çiftçilerin Bitki Koruma Ürünü Satın Alma Tercihlerinin Belirlenmesi: Iğdır İli Tarım Kredi Kooperatifleri Örneği
Authors: Akbaba Mustafa , Bulut Osman Doğan
Published: December 2024

Çiftçiler, üretim maliyetlerini düşürmek, pazarlama ve satış süreçlerini güçlendirmek ve finansal destek alabilmek için ortaklık esasına dayalı olarak tarımsal kooperatifleri kurmaktadır. Bu çalışmada çiftçilerin kooperatife ortak olma nedenleri, bitki koruma ürünü satın aldıkları yerlerden ihtiyaçlarını hangi oranda karşıladığı, bitki koruma ürünü satın alırken ve bitki koruma ürünü satın alacağı yer seçiminde önem verdiği kriterlerin belirlenmesi amaçlanmıştır. Basit tesadüfi örnekleme yöntemi kullanılarak örneklem hacmi belirlenmiştir. Iğdır ili Merkez veya Yaycı Tarım Kredi Kooperatif ortağı 100 üretici ile yüz yüze görüşmeye dayalı anket çalışması yapılmıştır. Çalışmanın istatistiksel analizinde Mann-Whitney-U testi kullanılmıştır. Çiftçilerin kooperatife ortak olma nedenlerinden ilk üçü sırasıyla; tarımsal kredi alabilmek (4,89 puan), bitki koruma ürünü alabilmek (4,85 puan) ve bitki besleme ürünü alabilmek (4,84 puan) olup ortağı olunan kooperatife göre istatistiksel anlamlı bir fark yoktur (p>0,05). Kooperatif ortakları bitki koruma ürünü ihtiyaçlarının büyük bir kısmını Tarım Kredi Kooperatifleri (%75,56) ve zirai ilaç bayilerinden karşılamaktadır (%22,06). Çiftçilerin bitki koruma ürünü satın alırken en çok önem verdiği kriter ürünün son kullanma tarihidir (4,66). Yaycı Tarım Kredi Kooperatif ortakları Merkez Tarım Kredi Kooperatif ortaklarına göre bu kritere daha fazla önem vermektedir (p<0,05). Çiftçilerin bitki koruma ürünü satın almak için yer seçiminde en çok önem verdiği kriter ise 4,84 puan ile güvenilir olmasıdır (p>0,05).
Evaluation of The Effects of Tarantula Cubensis Alcohol Extract and Sorafenib Treatments on P21 Protein, Total Antioxidant Capacity and Metabolic Profile in Experimental Rats Hepatocellular Carcinoma
Authors: Vanlı Serdar , Kurtoğlu Firuze , Suvarıklı Alan Beyza , Akçakavak Gökhan , Özdemir Özgür
Published: December 2024

Hepatocellular carcinoma (HCC) is defined as the sixth most common cancer type and the third most common cancer type in terms of cancer-related deaths. Tarantula cubensis alcohol extract (TCAE, Theranekron) is a homeopathic medicine frequently used in veterinary medicine in the treatment of papilloma, mammary adenocarcinoma and necrotic disorders. The present study aimed to reveal the treatment effectiveness of TCAE and Sorafenib (S) in HCC induced by Diethylnitrosamine (DEN) and N-nitrosomorpholine (NMOR)-induced HCC in rats. Rats were randomly divided into 7 groups: Control (C), Control + TCAE (CT), Control + S (CS), Cancer Control (CC), CC+TCAE (CCT), CC+S (CCS), CC+TCAE+S (CCTS). In the CC group, the values for glucose, triglyceride (TG) and total antioxidant capacity (TAC) values were found to be significantly higher than in all other groups (p<0.001), while the p21 levels were found to be significantly lower (p<0.05). It determined an increase in serum p21 levels (p<0.05) and a significant decrease in glucose and TG levels (p<0.001) in the CCT, CCS and CCTS groups compared to the CC group. Histopathological examination revealed that the CC group showed cancer morphology, and the treatment groups caused a decrease in tumor incidence and size. As a result, it can be said that TCAE can be used alone and/or combined with chemotherapy drugs to reveal antiproliferative effects on cancer cells in HCC. Sorafenib and TCAE combination therapy may potentially synergize to improve the magnitude and durability of antitumor responses in patients with HCC.
Pengaruh Kualitas Jaringan, Direct Marketing Dan Kualitas Produk Terhadap Keputusan Pembelian Modem Orbit Di Telkomsel Batam
Authors: Natalia Br Sembiring  , Tiurniari Purba
Published: December 2024

Penelitian ini bertujuan untuk menginvestigasi pengaruh kualitas jaringan, direct marketing, dan kualitas produk terhadap keputusan pembelian modem Orbit di Telkomsel Batam. Jenis penelitian ini menggunakan deskriptif yang dipandukan dengan pendekatan kuantitatif. Populasi yang diteliti terdiri dari 332 konsumen berdasarkan data jumlah konsumen yang menggunakan modem orbit Telkomsel Batam pada bulan Desember 2023. Teknik penentuan sampel menggunakan rumus Slovin dengan menghasilkan 181 responden yang ditarik didasari simple random sampling. Metode analisis data menggunakan uji kualitas data, uji asumsi klasik, uji pengaruh dan uji hipotesis. Temuan analisis regresi linier berganda menunjukkan bahwa kualitas jaringan berkontribusi  sebesar 31,5% dalam mempengaruhi keputusan pembelian. Direct marketing berkontribusi  sebesar 32,1% dalam mempengaruhi keputusan pembelian. Kualitas produk berkontribusi  sebesar 16,2% dalam mempengaruhi keputusan pembelian. Analisis koefisien determinasi (R2) menunjukkan bahwa keputusan pembelian dapat dijelaskan oleh kombinasi kualitas jaringan, direct marketing, dan kualitas produk sebesar 71,9%. Hasil uji t dan uji F mengungkapkan bahwa kualitas jaringan, direct marketing, dan kualitas produk berpengaruh positif dan signifikan dalam mempengaruh keputusan pembelian, baik secara parsial maupun simultan
Comprehensive analysis of adrenal crisis management: Emergency and paramedic interventions in acute endocrine emergencies
Authors: Jado Alanazi Yasmeen Alhumaidi , Alotaibi Mokhld Sanhat , AlAnizi ‏Aljazi Awadh , Alanzi Nuri  Rawafa , Alanizi Layla Aqeel , Almasoudi Ishraq Hassan , Alqahtani Khalid Moaed , Alshehri Alaa Ali , Abdullah Alqahtani Naif Saad , Saeed Alamri Fouad Hamed , K Elyas Mohanad Emad , Aljehani Mohammad Raja , Alruwaili Mohammed Menwer , Muhammad Al-Nami Abdul Rahman Saleh , Alsahli Saif Sultan , Al Suliman Jumanah  Mmed , Safi Alanazi Nadyah Khalaf , N Alruwas Mutlaq Gatar
Published: December 2024

Background: Adrenal crisis, also known as Addisonian crisis, is a life-threatening emergency caused by acute adrenal insufficiency, which can result from various factors including autoimmune adrenalitis, infections, physical trauma, and sudden discontinuation of glucocorticoid treatment. The condition is associated with significant mortality rates and rapid clinical deterioration if not promptly treated. Early recognition and immediate intervention are essential for improving patient outcomes. This article explores the management of adrenal crisis in emergency medical settings, focusing on paramedic interventions. Aim: This study aims to provide a comprehensive analysis of the clinical management of adrenal crisis, with a particular focus on the role of paramedics and emergency medical services (EMS) in early intervention and patient stabilization. Methods: A review of current literature on adrenal crisis was conducted, with emphasis on the pathophysiology, precipitating factors, clinical features, and emergency management strategies. Key interventions by paramedics, including fluid resuscitation, administration of hydrocortisone, and supportive care, were examined. Results: The study found that prompt administration of parenteral glucocorticoids, particularly hydrocortisone, significantly improves survival rates. Paramedics play a crucial role in early diagnosis, stabilization, and rapid transportation to healthcare facilities.
IMPACT OF DIGITAL FINANCIAL LITERACY ON CONSUMER PROTECTION, INVESTOR SECURITY, AND FINANCIAL TRANSACTIONS IN INDONESIA
Authors: Hasan Zulfikar
Published: December 2024

This study examines the influence of digital financial literacy on consumer protection, investor security, and financial transactions in Indonesia. As digital financial services rapidly expand across the country, understanding the level of financial literacy among consumers becomes crucial. This study explores how adequate digital financial literacy enhances consumer protection by empowering individuals to make informed financial decisions and protect themselves against potential risks. Moreover, it investigates the correlation between digital financial literacy and investor security, highlighting the role of education in mitigating investment-related vulnerabilities. Furthermore, this study analyzes the impact of digital financial literacy on the efficiency and safety of financial transactions, emphasizing the importance of education in promoting secure and efficient financial practices. The findings underscore the need for targeted educational programs and policy initiatives aimed at improving digital financial literacy to foster a more secure and resilient financial ecosystem in Indonesia.
BIBLIOMETRIC ANALYSIS OF IMPLEMENTATION OF FINANCE TECHNOLOGY IN ENDOWMENT MANAGEMENT
Authors: Ahmad Syarbaini , Basri Mokmin , Muhamad Hilmi Ahmad Misbah , Kasbun Rafiza
Published: December 2024

This paper presents a bibliometric analysis of the evolving landscape of fintech applications within endowment fund management. By examining a comprehensive dataset of academic publications from various databases, the study identifies key trends, influential authors, and prominent research clusters in the field. The analysis reveals the growing importance of technological innovations, such as blockchain, artificial intelligence, and machine learning, in enhancing endowment fund performance, risk management, and governance. Furthermore, the study uncovers the geographical distribution of research, highlighting leading institutions and countries contributing to this domain. The findings provide valuable insights for academics and practitioners, emphasizing emerging research areas, potential collaborations, and the implications of fintech advancements on the strategic management of endowment funds. This study contributes to a deeper understanding of how fintech is reshaping endowment fund management and offers a foundation for future research directions.
Trust Dynamics of Vietnamese EFL Teachers towards AI-Driven Educational Tools
Authors: Hieu Hua Hong , Thao Le Thanh
Published: December 2024

With the proliferation of Artificial Intelligence (AI) in educational realms, understanding trust dynamics is paramount, especially within diverse cultural contexts. This qualitative study delved into the perspectives of nine Vietnamese EFL teachers from two higher educational institutions, aiming to uncover the challenges and considerations in building trust towards AI-driven educational tools. Utilizing semi-structured interviews, the research was anchored on two theoretical frameworks: the Technology Acceptance Model and the Sociocultural Theory. Four predominant themes surfaced: the trust dichotomy in AI’s personalized learning capacity, AI’s interpretation of cultural context, the transparency of AI decision-making, and the interplay of AI’s emotional intelligence in trust-building. Findings revealed that while there is acknowledgment of AI’s potential, genuine trust hinges on its ability to capture the sociocultural and emotional essence of language learning. Teachers yearn for AI tools that are culturally attuned, emotionally responsive, and transparent in their methodologies
Social Capital and Management Synergies: Exploring Transmigrant Communities' Development in Halmahera Island
Authors: Basuki Natal , Djumadil Nurdiyanawati , Mahmud Haris , Sangadji Suwandi S. , Sudarnice Sudarnice
Published: December 2024

This study explores how social capital is formed and utilized in transmigrant communities on Halmahera Island, Indonesia, and examines the role of management synergies in enhancing community resilience and sustainable development. Using a qualitative case study approach, data were collected through semi-structured interviews, focus group discussions, and participant observation. The findings reveal that bonding social capital within ethnic groups fosters trust and mutual support, though it can limit interaction with local communities. Bridging social capital, while less developed, is crucial for cross-group cooperation. Additionally, management synergies—through coordinated efforts among community leaders, local governments, and NGOs—enhance resource mobilization and the implementation of development projects. Leadership plays a key role in these synergies, facilitating collaboration and inclusive decision-making. The study highlights the mutually reinforcing interaction between social capital and management synergies, which contributes to the long-term sustainability of transmigrant communities.
Ethical Aspects in Legal Management: A Unique Approach to Addressing Moral Dilemmas in Business Decision-Making
Authors: Widjaja Gunawan
Published: December 2024

In an increasingly complex and rapidly changing business environment, ethical dilemmas become routine challenges in decision-making. The study examines the importance of ethical aspects in legal management as a foundation for dealing with moral dilemmas in business decision-making. This analysis highlights how ethical dilemmas affect law management policies and practices and the potential positive outcomes of decisions taken with adequate ethical consideration. Using a qualitative approach and relevant literature studies, the study outlines the need to integrate ethical principles into business strategy and operations through the formulation of ethical codes, ethical training, breach reporting mechanisms, and ethical decision-making. Research results show that applying ethical aspects in law management not only improves legal compliance and minimizes risk but also plays a crucial role in building reputation, public trust, and long-term business sustainability. The conclusion emphasizes the importance of ethical aspects in law management to create value and strengthen the organization's integrity in the eyes of stakeholders, thereby reassuring them about the organization's credibility.
Enhancing SME impact on Economic Development in Sultanate of Oman
Authors: Muthuraman Subrahmanian
Published: December 2024

Small and medium-sized enterprises (SMEs) are a significant driving force behind Oman's economic growth. The government, academics, and economists agree that promoting entrepreneurship and small business development is an effective strategy for economic development. The purpose of this study is to investigate the role of SME entrepreneurs in economic development and examine the impact of SMEs on capacity building, employment generation, competitive markets, and technological development in Oman. The research design is empirical, and data was collected from 174 SME entrepreneurs in Oman. Structural Equation Modeling analysis revealed a significant and positive indirect effect of SMEs on economic development, with a path coefficient of 0.274 and a t-value of 2.562. From a socio-economic perspective, SMEs provide various benefits, including job creation, human capacity building, promoting competitive markets, and developing new technologies. Therefore, it is essential for governments to recognize the contributions of SMEs to national economy and wealth creation from the outset and incorporate them into the economic development process. The study's findings will provide guidance for developing new SMEs and understanding the expected role of SME entrepreneurs in contributing to economic development in Oman through capacity building, employment generation, promoting competitive markets, and technological development.
Human Value in the Process of Commodity Economic Development
Authors: Quoc Nguyen Anh
Published: December 2024

This content aims to clarify human values expressed through personal life and concretize them in career and job positions. Productivity and work efficiency are labor values expressed in money in a market economy. Philosophically, this topic is approached by the methodology of humans and society, combined with qualitative and quantitative research methods such as analysis, synthesis, comparison, and contrast. The inversion method analyzes the relationship between individuals and money. The research results show that humans are both subjects and objects of social life. Human values are respected and expressed through product value, which is affected by the laws of supply and demand, competition, and the market. Treating humans as a commodity can lead to inequality and discrimination. The article concludes that humans are different from animals in that humans create and live in an artificial world, every profession has value and contributes to the existence of society, and discrimination causes conflict. It hinders the development of society. Human value in a market economy is expressed through labor, occupation, and job position, directly affecting product quality and price. The real struggle is to eliminate injustice and protect human rights.
The Development of Indonesian Monetary Policy in Digital Currencies
Authors: Widjaja Gunawan
Published: December 2024

This research investigates the dynamic interplay between digital currencies and monetary policy in Indonesia, offering a comprehensive analysis of historical development and the current regulatory framework. The study synthesizes key findings through an extensive literature review, highlighting common themes and diverse perspectives within the rapidly evolving field of digital currencies. Practical implications for Indonesia's economic landscape and monetary policy are discussed, emphasizing the crucial need for adaptive regulatory frameworks that balance innovation and financial stability. The research identifies challenges and opportunities associated with the adoption and regulation of digital currencies, with a specific focus on leveraging these assets for financial inclusion and positioning Indonesia as a critical player in the global fintech landscape. Additionally, the study advocates for future research to explore nuanced socio-economic impacts, environmental considerations, and other areas requiring further investigation. In conclusion, this research underscores the importance of comprehending the evolving dynamics of digital currencies, providing a foundation for well-informed decision-making in Indonesia's monetary policy realm.
Empirical Insight into Solvency Constraint and Tax Planning Dynamics in Ghanaian Banking Sector: A Non-Linearity Approach
Authors: Boateng Kwakye , Omane-Antwi Kwame Bosiako , Queku Yaw Ndori
Published: December 2024

This paper examines the relationship between tax planning activity dynamics and solvency constraints within the Ghanaian banking sector. This is conceived on the premise that banks are likely to change their tax planning dynamics in the midst of solvency challenges to boost their after-tax capital position to minimize the exposure to the going concern problem. The study employs the quantile regression estimation to draw time-varying constraint scenarios to measure solvency constraint proxies: WW index, HP index, and Z-score. Tax planning activity is also measured through cash effective tax rate. Annual data from 2008 to 2022 are used for the investigation with the unit of analysis expanding to cover all licensed banks which have been in operation within the study span. The study employed a quantile estimation approach to conduct the analysis. It is observed that the nature and trend in tax aggressiveness of the banks under a solvency-constraint scenario is dependent on the measurement of the constraints. Nevertheless, the study found non-linearity in the solvency-constraint and tax planning nexus. The banks do not generally alter their tax planning behaviour at the initial stage of the constrained scenario, however, turn to be relatively aggressive when the solvency constraint amplifies. The government is advised to protect the banks not to fall into any solvency constraint situation since that could change their tax planning activities.
A novel application of neurite orientation dispersion and density imaging to differentiate cognitively recovered versus non-recovered following mild traumatic brain injury
Authors: Swaminathan Prasath , Hamzah Norhamizan , Narayanan Vairavan , Tan Li Kuo , Rahmat Kartini , Norlisah Ramli
Published: December 2024

Objective: Cognitive deficits in mild traumatic brain injury (mTBI) can persist over three months, and symptomatic patients may not be readily diagnosed. Although diffusion tensor imaging (DTI) can detect microstructural white matter tract (WMT) changes in mTBI, the underlying recovery process is not fully understood. We aimed to investigate WMT changes at 3 months post-mTBI between cognitively recovered (REC) and non-recovered (NREC) mTBI subjects using diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI).
Methods: Fifty-seven mTBI subjects were divided into REC (n=16) and NREC (n=41) groups. Ten healthy controls (HC) were recruited. MRI and Neuropsychological Assessment Battery-Screening Module (S-NAB) performance were assessed at baseline and three months before subjects were classified as REC and NREC. DTI and NODDI parameters of 50 ROIs corresponding to WMTs were compared between REC, NREC and HC.
Results: NODDI detected more significant changes (p<0.05) in multiple ROIs than DTI. Lower Neurite Density Index (NDI) was demonstrated in REC versus NREC at multiple ROIs. Increased Orientation Dispersion Index (ODI) and decreased Isotropic Volume Fraction (ISOVF) were detected at several WMTs in both groups.
Conclusion: Reduced NDI in the overall mTBI cohort suggests axonal degeneration post-trauma. We postulate that at three months’ timeline, there is a combination of axonal degeneration and astrogliosis, which is more extensive in NREC than REC.
A new nomogram for predicting the prognosis based on 24-hour blood pressure variability after intravenous thrombolysis
Authors: Liu Zi-Qing , Zhang Chuan-Zhuo , Li Ming-Jie , Liu Bo , Liu Bing , Zheng Rui-Han , Zhang Ben-Ping
Published: December 2024

Background & Objective: There is insufficient research on the use of population data to construct a predictive model of blood pressure variability (BPV) after thrombolysis to estimate the subsequent development of acute ischemic stroke (AIS) patients. The aim of this study is to construct and validate a model that uses BPV 24 hours after thrombolytic therapy to predict outcome in patients with AIS.
Methods: To construct and validate a model that uses BPV 24 hours after thrombolytic therapy to predict outcome in patients with AIS.
Results: A total of 503 patients with acute ischemic stroke who received intravenous thrombolytic therapy were enrolled in the study. The multivariate analysis outcomes have delineated several pivotal factors that are significantly prognostic of adverse outcomes in AIS patients post-thrombolysis: The initial National Institutes of Health Stroke Scale score, a recorded history of hypertension, the variability in systolic and diastolic blood pressure as indicated by their standard deviation, and the blood pressure measurements recorded 24 hours subsequent to thrombolytic therapy. These determinants have emerged as substantial predictors, shedding light on the complex interplay of clinical parameters that influence patient prognosis following AIS treatment. Within the development and validation cohorts, the area under the curve for the nomogram, which estimates the probability of an unfavorable prognosis, was determined to be 0.876 (95%CI: 0.84–0.913) and 0.849 (95%CI: 0.784–0.913), respectively. The calibration curve revealed a striking congruence between the predicted probabilities by the nomogram and the actual outcomes observed in the validation set. Furthermore, the decision curve analysis underscored the significant clinical utility and robust applicability of the prognostic model, illustrating its potential to guide clinical decision-making effectively.
Conclusion: Because of its superior predictive accuracy, discriminative power, and clinical utility, the nomogram is an important adjunct tool for the assessment of possible adverse outcomes in patients with AIS following thrombolytic therapy.
Clinical significance of elevated serum cardiac troponin T and associated risk factors in patients diagnosed with acute ischemic stroke
Authors: Guo Qin , Song Xuhui , Liu Zejiang , Long Qiyun , Lin Sheng , Qi Xing , Wang Huaguo
Published: December 2024

Objective: We explored the clinical significance and associated risk factors of increased levels of serum cardiac troponin T (cTnT) in individuals suffering from acute ischemic stroke (AIS).
Methods: Our study subjects consisted of patients who were admitted with AIS within 48 hours of its onset. These study participants were categorized based on their levels of cTnT into two groups: normal cTnT group and elevated cTnT group. We collected and subjected a range of data to statistical analysis, including general clinical traits, medical history, laboratory test results, electrocardiograms, imaging scans, and medical records like the National Institute of Health Stroke Scale (NIHSS) scores of the patients.
Results: Out of the 232 patients diagnosed with AIS, 84 individuals (36.21%) exhibited raised levels of cTnT. When comparing this elevated cTnT cohort to the group with regular cTnT levels, those with elevated cTnT were older [with a median age of 76 year (interquartile range: 67 to 83) as compared to 70 year interquartile range: 61 to 79), P = 0.002], and they presented with higher NIHSS scores upon admission [8.5 (interquartile range: 4 to 14) compared to 5 (interquartile range: 2 to 9), p = 0.002]. In addition, a larger percentage of patients in the elevated cTnT group had both coronary artery disease (23.81% vs. 7.43%, P < 0.001) and cardiac insufficiency (25.00% vs. 3.38%, P < 0.001) as comorbidities. Meanwhile, the elevated cTnT group also displayed a higher occurrence of electrocardiogram abnormalities, including bundle branch block (29.76% vs. 9.46%, P < 0.001) and atrial fibrillation (32.14% vs. 11.49%, P < 0.001), in comparison to the normal cTnT group. The clinical data and related laboratory indicators of patients were collected for risk factor analysis, which showed that bundle branch block [odds ratio (OR) = 4.17, 95% confidence interval (95%CI) = 1.43–12.16), log to base 10 N-terminal pro-brain natriuretic peptide (Log10NT-proBNP; OR = 3.41, 95%CI = 1.62-7.16), cystatin C (OR = 6.86, 95%CI = 2.01–23.43), and neutrophil/lymphocyte ratio (OR = 1.13, 95%CI = 1.02–1.25) were independent risk factors for elevated cTnT in patients with AIS.
Conclusions: Older patients with AIS who had higher levels of cTnT exhibited more severe neurological impairments and a greater number of comorbidities. Furthermore, an elevated cTnT in patients with AIS may be linked to cardiac insufficiency, changes in kidney function, and signs of inflammation.
Blood-nerve barrier: Structure and opening
Authors: Sun Tao , Huang Lixin , Zeng Qiuhua , Sun Jun , Wu Zhimin , Chen Chuan , Wang Hui
Published: December 2024

Like the blood-brain barrier and blood-spinal cord barrier, the blood-nerve barrier (BNB) is one of the crucial tissue barriers of the nervous system. It plays a vital role in homeostasis, physiological protection, and pathological reactions. Various factors, such as biological, physical, and chemical factors, can lead to transient or permanent dysfunction of the BNB. With the advancements in biological techniques and the growing peripheral nerve injuries such as trauma and diabetic peripheral neuropathy, the BNB has gained increasing attention. Moreover, the defensive function of the BNB impedes therapeutic deliveries and anesthetic drugs, which compromises the therapeutic experiences and life quality. It should be noted that numerous pathways are involved in the microstructure, function, and opening of the BNB, but the true underlying molecular mechanisms are still under constant exploration and investigation. This review summarizes the microstructure, and signaling pathways of the BNB, and thoroughly discusses the transient or permanent disruptions of the BNB in both physiological and pathological conditions.