bluuebunny/crossref_metadata_2025 huggingface dataset:
BRCA1/2 reversion mutations in pancreatobiliary cancer identified from patient biopsies.
Authors: Gay Laurie M. , Gornstein Erica , Frampton Garrett Michael , Sun James , Morley Samantha , Heilmann Andreas , Chung Jon , Daniel Sugganth , Ramkissoon Shakti , Severson Eric Allan , Suh James , Vergilio Jo-Anne , Stephens Philip J. , Miller Vincent A. , Elvin Julia Andrea , Ross Jeffrey S.
Published: July 2017

4130

Background: Germline genomic alterations (GA) in BRCA1 or BRCA2 ( BRCA) are associated with increased risk of pancreatic cancer. Tumors with BRCA GA may be more sensitive to platinum (Pt) therapies or PARP inhibitors (PARPi). However, secondary reversion mutations (revGA) that may restore BRCA function and underlie reduced sensitivity to Pt compounds or PARPi can arise. Methods: DNA extracted from FFPE tumor tissue obtained during routine clinical care for 7077 patients with predominantly relapsed, refractory or metastatic pancreatobiliary carcinoma was analyzed using comprehensive genomic profiling (CGP) for all classes of GA: base substitutions, indels, rearrangements, and copy number changes. RevGA were any GA that could restore the reading frame if in cis with a nonsense or frameshift (fs) GA. Tumor tissue only was used to predict germline (g BRCA) or somatic status by an algorithm with a call rate of 85% and > 95% accuracy. Results: 417/7077 (5.9% ± 0.5%) tumors had ≥1 deleterious BRCA GA; 205 (2.9% ± 0.4%) had a predicted g BRCA GA. Significantly fewer women had deleterious BRCA GA (182/417; 43.6%)(p = 0.02); g BRCA GA frequency did not differ significantly (96/205; 46.8%)(p = NS). Overall, 49.1% of patients were women. 12 samples harbored potential revGA: pancreatic ductal adenocarcinoma (ACa) (7) or acinar cell carcinoma (Ca) (2), gallbladder ACa (2), and pancreatobiliary Ca NOS (1). 10/12 samples with revGA were metastases. Potential revGA were of 3 types: overlapping indel (7), compensatory fs (4), and missense (2). One case harbored 2 indels, both with potential to excise a fs GA. Apparent g BRCA were present in 7 cases, only somatic BRCA GA in 3 cases, and g BRCA/somatic status was ambiguous in 2 cases. For 2 patients, testing of multiple samples reveals the acquisition of revGA over time. KRAS mutation frequencies were similar for all samples (57.1%), BRCA-mutated samples (58.8%) and revGA-positive samples (58.3%). Clinical histories for patients with revGA will be presented. Conclusions: CGP of 7077 pancreatobiliary carcinomas reveals 5.9% had ≥1 deleterious BRCA GA, nearly 50% of which were g BRCA. Although rare, revGA can be acquired over time and potentially compensatory missense, fs and indel mutations were observed.
ATM/RB1 mutations to predict shorter overall survival (OS) in bladder cancer.
Authors: Joshi Monika , Grivas Petros , Ali Siraj Mahamed , Hsu Joann , Vasekar Monali K. , Emamekhoo Hamid , Pal Sumanta K. , Li Sierra Min , Drabick Joseph J. , Yin Ming
Published: July 2017

4547

Background: DNA repair defect plays an important role in tumorigenesis, progression and treatment outcomes of urothelial cancer. Somatic mutations of ATM/RB1 genes are frequently found in urothelial cancer and have been associated with a better response to cisplatin-based neoadjuvant chemotherapy. However, their prognostic value overall in urothelial cancer have not been determined. Methods: Exome sequencing data of 130 urothelial bladder cancer patients (pts) from The Cancer Genome Atlas (TCGA) dataset were analyzed as a discovery cohort to determine the prognostic value of ATM and RB1 mutations. Results from discovery dataset were further validated by an independent cohort of 79 advanced urothelial cancer pts who received comprehensive genomic sequencing for urothelial cancer with FoundationOne. OS was measured from time of initial diagnosis and Cox proportional hazard regression analysis was performed to calculate the hazard ratio (HR) and 95% confidence interval (CI). Results: In the discovery dataset, somatic mutations of ATM/RB1 genes were present in 24% of pts and were associated with significantly shorter OS [all stages: adjusted HR = 2.67, 95% CI, 1.45–4.92, P = 0.002; stage II-III only: adjHR = 2.76, 95% CI, 1.23–6.20, P = 0.014]. There was high mutation load in pts carrying ATM/RB1 mutations (median mutation count: 196 versus 160, P = 0.09). In the validation (stage IV) dataset, ATM/RB1 mutations were present in 31.7% of pts and tended to associate with shorter OS (adjHR = 1.97, 95% CI, 0.89–4.40, P = 0.094) and higher mutation load (median mutation load: 8.1 versus 7.2 per Mb, P = 0.136), although statistical significance was not reached. Conclusions: These results suggest that ATM/RB1 mutations may be considered as a poor prognostic biomarker in unselected urothelial cancer pts and may correlate with higher mutational load. Further studies are required to determine patient characteristics that can further stratify prognosis based on ATM/RB1 mutation status, and evaluate the potential predictive role of ATM/RB1 mutation status in response to immunotherapy.
Association of tumor mutational burden in cutaneous squamous cell carcinoma with genomic alterations in Notch family receptors.
Authors: Severson Eric Allan , Ramkissoon Shakti , Daniel Sugganth , Vergilio Jo-Anne , Gay Laurie M. , Elvin Julia Andrea , Suh James , Frampton Garrett Michael , Ali Siraj Mahamed , Miller Vincent A. , Ross Jeffrey S.
Published: July 2017

e13031

Background: In Cutaneous Squamous Cell Carcinoma (cSqCC), Notch1, Notch2, and Notch3 have been identified as tumor suppressors with a high rate of inactivating mutations early in cSqCC pathogenesis. Despite the high frequency of alterations, the biologic and therapeutic implications of Notch genomic alterations (GAs) in cSqCC are incompletely understood. Methods: 232 FFPE samples of cSqCC were evaluated by comprehensive genomic profiling (CGP) of 315 genes and analyzed for all classes of GAs, with diagnoses confirmed by central pathology review. Notch GAs with unknown functional impact were excluded. Tumor mutational burden (TMB) was calculated from 1.11 Mb of sequenced DNA and reported as mutations/Mb. Results: The cohort of 232 samples was 78% male and 22% female, aged from 17 to 88, with confirmed metastatic disease in 32% of cases. 115 (50%) samples had a Notch family member GA with a known or predicted functional impact. 96 cases had Notch1 GAs, 43 cases had Notch2 GAs, and 14 cases had Notch3 GAs with 40 cases having GAs in multiple Notch family members. These mutations were 41% missense, 34% nonsense, 15% splice site, 9% frameshift indels, and 1% non-frameshift indels alterations. Patients with Notch GAs were significantly older (median 70 years old vs median 64, p < 0.01). TMB was increased among samples with Notch GAs (median TMB of 63 mutations/mb versus 20 mutations/mb, p < 1x10-6), with similar differences for primary and metastatic samples. Cases with Notch GAs had more total GAs per case (mean 10.4 vs 7.4, p < 1.5x10-10); however, the top co-mutated genes were the same (TP53, CDKN2A, FAT1, MLL2). Both groups had a high proportion of C- > T/G- > A transitions, consistent with UV damage; however, the proportion was higher in cases with Notch GAs (median 83% vs 80%) - a difference seen in primary and metastatic samples. Conclusions: 50% of cSqCC cases had a Notch family member loss of function GA, which was associated with increased TMB in the primary and metastatic setting. With pre-clinical models and case studies showing responses to PD-1 inhibitors in cSqCC, further investigations are warranted into the associations of Notch GAs with mutational burden and response to immunotherapy.
FoundationOne as a relevant tool for comprehensive genomic profiling and assessment of tumor mutation burden in the era of precision oncology in India.
Authors: Verma Amit , Rohatgi Nitesh , Julka Pramod Kumar , Walia Meenu , Bahl Ankur , Arora Ramandeep Singh , Chaturvedi Harit , Anand Anil Kumar , Rao Ranga , Gay Laurie M. , Kaur Jatinder
Published: July 2017

e23096

Background: Comprehensive genomic profiling (CGP) is gaining acceptability globally, but clinical experience in developing countries like India is limited. CGP identifies genomic alterations (GA), with tumor mutation burden (TMB) and microsatellite status (MSI), revealing therapeutic options such as targeted inhibitors and immunotherapies. We sought to evaluate the mutation frequency and actionability across tumors. Methods: Metastatic and/or refractory patients (referred to Personalized Cancer Medicine Clinic) underwent CGP analysis, including calculation of TMB and MSI, using a targeted NGS panel (FoundationOne, 53 samples; FoundationOne Heme, 4 samples). This panel detects all relevant classes of GA: base substitutions, small indels, rearrangements and copy number changes. Mutation frequencies were compared with the larger Foundation database. TMB status was reported as low (≤5 mutations/Mb), intermediate (6-19 mut/Mb) or high (≥20 mut/Mb). Results: The most common tumor types were lung (23%), breast (14%) and sarcoma (12%); other tumor types, including unknown primary constituted the rest (51%). Most samples were from metastatic sites (60%). Oncogenic GA were found in 131 genes across all tumor subtypes and affected major pathways: apoptosis/cell cycle (31%), PI3K (14%), transcriptional regulation (13%), and receptor tyrosine kinases (10%). Among these GA, 38 were considered actionable and were distributed across 43 (75%) samples. Therapies with FDA approval for the tumor type analyzed were indicated for 18 samples; an additional 25 samples had GA associated with therapies FDA approved for another indication. More than 1 actionable GA was identified in 24/43 (56%). TMB status was low in 36 (63%), intermediate in 19 (33%) and high in 2 (3.5%). High TMB status correlated with high MSI status (p < 0.001). Trend observed in the mutation frequency was comparable with the larger Foundation database. Conclusions: This is the first study in India showing CGP identified actionable targets associated with FDA approved therapies in approx. 32% of cases. TMB status identified 2/57 samples with high mutation burden for whom immunotherapy might be relevant.
Persistent Severe Hyperlactatemia and Metabolic Derangement in Lethal SDHB-Mutated Metastatic Kidney Cancer: Clinical Challenges and Examples of Extreme Warburg Effect
Authors: Lee Chung-Han , Gundem Gunes , Lee William , Chen Ying-Bei , Cross Justin R. , Dong Yiyu , Redzematovic Almedina , Mano Roy , Wei Elizabeth Y. , Cheng Emily H. , Srinivasan Ramaprasad , Oschwald Dayna , Hakimi A. Ari , Dunphy Mark P. , Linehan W. Marston , Papaemmanuil Elli , Hsieh James J.
Published: July 2017

Purpose

To describe the unique clinical features, determine the genomics, and investigate the metabolic derangement of an extremely rare form of a hereditary lethal kidney cancer syndrome.

Patients and Methods

Three patients with lethal kidney cancer (age 19, 20, and 37 years) exhibiting persistent (1 to 3 months) extremely high levels of blood lactate (> 5 mM) despite normal oxygen perfusion, highly avid tumors on [18F]fluorodeoxyglucose positron emission tomography (PET), and pleomorphic histopathologic features were identified and treated in a single institute. Integrated studies including whole-genome sequencing (WGS), targeted sequencing, immunohistochemistry, cell-based assays, and 18F-glutamine PET imaging were performed to investigate this rare kidney cancer syndrome.

Results

All three patients with kidney cancer were initially given various diagnoses as a result of diverse tumor histopathology and atypical clinical presentations. The correct diagnoses of these SDHB-mutated renal cell carcinomas were first made based on cancer genomics. Genomic studies of the blood and tumors of these patients identified three different kinds of germline loss-of-function mutations in the SDHB gene and the common loss of heterozygosity in the remaining SDHB allele thorough somatic chromosome 1p deletion. In one patient, WGS revealed that a germline mutation of SDHB coupled with loss of heterozygosity was the sole genetic event. Cancer evolution analysis of SDHB tumors based on WGS demonstrated that SDHB in kidney epithelium fulfills the Knudson two-hit criteria as a major tumor suppressor gene. SDHB−/− tumor cells displayed increase in glucose uptake and lactate production, alteration in mitochondrial architecture, and defect in oxidative respiration. 18F-Glutamine PET imaging studies demonstrated increased glutamine metabolism.

Conclusion

SDHB-deficient metastatic renal cell carcinoma is a rare, aggressive form of kidney cancer that manifests with clinical evidence of a severe Warburg effect, and genomic studies demonstrated two genetic hits at SDHB genes during kidney tumorigenesis.
Thyroid-Specific T Cells in Patients With Differentiated Thyroid Cancer: Implications for Immune-Based Therapies?
Authors: French Jena D. , Haugen Bryan R.
Published: July 2017

This editorial reviews the recent paper by Ehlers et al and provides a perspective on thyroid cancer immunology.
Ringer’s Lactate Versus Normal Saline in Urgent Cesarean Delivery in a Resource-Limited Setting: A Pragmatic Clinical Trial
Authors: Ayebale Emmanuel Timarwa , Kwizera Arthur , Mijumbi Cephas , Kizito Samuel , Roche Anthony Michael
Published: July 2017

BACKGROUND:

Crystalloids are used routinely for perioperative fluid management in cesarean delivery. Few studies have determined the crystalloid of choice in obstetric anesthesia. We compared the effects of Ringer’s lactate (RL) versus 0.9% normal saline (NS) on maternal and neonatal blood pH and 24-hour postoperative morbidity in urgent cesarean delivery in a low-resource setting. Our hypothesis was that RL would result in 30% less acidosis than NS.

METHODS:

This was a pragmatic prospective double-blind randomized controlled trial in the Mulago National Referral Hospital Labor Ward Theater from September 2011 to May 2012. Five hundred parturients were studied; 252 were randomly assigned to NS and 248 to RL groups. Preoperative and postoperative maternal venous blood gases and placental umbilical arterial cord blood gases were analyzed. The primary outcome was incidence of maternal acidosis, as defined by a postoperative drop in venous pH below 7.32 or reduction in base excess below −3 in a previously normal parturient. Maternal 24-hour postoperative morbidity, neonatal pH, and neonatal base excess were the main secondary outcomes. The study was registered in ClinicalTrials.gov as NCT01585740.

RESULTS:

The overall incidence of maternal acidosis was 38% in NS and 29% in RL (relative risk, 1.29; 95% confidence interval, 1.01–1.66; P = .04). Thirty-two percent of parturients in NS experienced a drop in venous pH below 7.32 postoperatively, compared with 19% in RL (relative risk, 1.65; 95% confidence interval, 1.18–2.31; P = .003). The comparative drop in base excess postoperatively below −3 between the 2 groups was not statistically significant. There were no significant differences in the incidence of maternal 24-hour postoperative morbidity events and neonatal outcomes between the 2 groups.

CONCLUSIONS:

NS may be a safe choice for intraoperative fluid therapy in urgent cesarean delivery as RL, albeit with an increased incidence of metabolic acidosis.
The First World War and the refugee crisis: historiography and memory in the Greek context
Authors: Salvanou Emilia
Published: July 2017

The paper aims to trace the historiographical construction of the Great War in the Greek national narrative. Its main argument is that although the First World War was more or less a shared experience among its participants, the way it was constructed as an event is aligned not to the experience as such, but to the national discourse that subsequently prevailed. In the Greek case, its historiographical construction took place in three main stages: the first during the interwar period, when the temporal framework of the event were set (the war decade of 1912–1922) and the interest was mainly in the military and political aspects. The second stage developed after the Second World War, when there was a turn towards testimonies and the field of refugee studies was shaped. It was during this stage that the memory of the refugees found its place in the national narrative. The third stage began in the last quarter of the twentieth century, when a split developed in the way the event is constructed in public and lay history and in the way it is constructed in academic historiography, where the limits of national historiographies are critiqued.
On the historiography of the language question in post-1974 Greece
Authors: Patrikiou Alexandra
Published: July 2017

The works of Alexis Dimaras, Rena Stavridi-Patrikiou and Anna Frangoudaki have undeniably shaped, each in a different way but positively all together, the framework within which the historiography of the language question evolved since the early years of the Metapolitefsi, as the post-dictatorship period is known in Greece. Commenting on the different interpretations and exposing main convergences and divergences between these works, one will be able to contemplate their contributions to historiography and to scholarly thought in general. The aim of this paper is to examine these works as products of their time and to demonstrate how in a period of transitions and ideological redefinitions a renewed relation to the past may have been developed.
Review of Maurizio Isabella and Konstantina Zanou, eds, Mediterranean Diasporas: Politics and Ideas in the Long 19th Century
Authors: Greene Molly
Published: July 2017

Maurizio Isabella and Konstantina Zanou, eds. Mediterranean Diasporas: Politics and Ideas in the Long 19th Century. London: Bloomsbury Academic, 2016. xiii + 217 pages
Review of George Th. Mavrogordatos', 1915: Ο εθνικός διχασμός [1915: The national schism]
Authors: Hatzis Aristides N.
Published: July 2017

George Th. Mavrogordatos. 1915: Ο εθνικός διχασμός [1915: The national schism]. Athens: Patakis, 2015. 343 pp.
Review of Harris Athanasiades', Τα αποσυρθέντα βιβλία: Έθνος και σχολική Ιστορία στην Ελλάδα, 1858-2008 [The withdrawn textbooks: nation and school history in Greece, 1858–2008]
Authors: Sakka Vassiliki
Published: July 2017

Harris Athanasiades. Τα αποσυρθέντα βιβλία: Έθνος και σχολική Ιστορία στην Ελλάδα, 1858-2008 [The withdrawn textbooks: nation and school history in Greece, 1858–2008]. Athens: Alexandreia, 2015. 295 pp.
Review of Sevasti Trubeta (ed.), Special issue, Zeitschrift für Balkanologie 50/1 (2014)
Authors: Mergoupi-Savaidou Eirini
Published: July 2017

Sevasti Trubeta (ed.). Special issue, Zeitschrift für Balkanologie 50/1 (2014)
Perspectives on the risks for older adults living independently
Authors: Verver Didi , Merten Hanneke , Robben Paul , Wagner Cordula
Published: July 2017

Insight into risks concerning older adults living independently from their own perspective and their care provider's perspective is essential to address issues that may threaten their independent living. The most often mentioned perceived risks by older adults and their care providers in different regions in the Netherlands were: loneliness, falls, budget cuts in Dutch long-term care and not being able to call for help. The different perspectives of the respondents show a wide variety in risks, but also some similarities. The perspective of the frail older adults is required to gain insight into the priority of their perceived risks. An additional finding was the reluctance shown by the older adults to ask others in their social network for help. Results imply that possible preventive measures should not only focus on the medical or physical domain because older adults are likely to have other priorities to maintain self-reliance and live independently.
Pain in labour and the intrapartum use of intramuscular opioids—how effective are they?
Authors: Sprawson Emma
Published: July 2017

Although widely used, there are observable differences in the level of satisfaction that women receive from opioids. This review examines some of the factors impacting this satisfaction, considering both physiological and psychological differences.

Many women choose pharmacological methods for pain management in labour, with 25% using an opiate-based analgesic ( Redshaw and Henderson, 2015 ). Statistics suggest that the level of intravenous or intramuscular opiate ranges from 5% to 66% between hospital trusts ( Healthcare Commission, 2007 ).

This review will consider the evidence and management options regarding the role of pain in labour; provide an overview of the research, evidence and practices concerning the intrapartum use of opiates versus other methods of pain management; detail the pharmacokinetics of opiates that are used in the UK and their effects on the woman, fetus and neonate; and identify some of the gaps in the literature.
Learning by listening to women: A supervisor of midwives' initiative
Authors: Stalberg Philippa
Published: July 2017

Supervisors of Midwives (SoMs) at Lewisham and Greenwich NHS Trust (LGT) found immense value in actively listening to women about their preferences for birth and their experiences of the maternity service. This was enhanced and facilitated through the provision of a ‘SoM clinic’ (now known as the ‘Listening Clinic’ after this year's conversion of the SoM role to Professional Midwifery Advocate (PMA)), which was evaluated highly by women, well used by staff and a contributor to learning and development within the service. The organisation of the clinic will be described along with examples of feedback received from women. Consideration is given to how this can be incorporated into the service in line with the vision of Better Births ( NHS England, 2016a ) and developed within the new Advocating for Education and Quality Improvement (A-EQUIP) model of supervision. Quotes from women seen in the clinic have been included from personal correspondence and from an anonymous SurveyMonkey survey carried out in 2016.
Studies on the Pesticidal Activities of Bioactive Compounds of Fish Tetraodon fluviatilis of West Coast of Mumbai
Authors: G. V. Zodape
Published: July 2017

ABSTRACT: In case of Sitopbilus oryzae, Periplaneta americana and Gumbusia affinis (girard), 100 % mortality was noted after 24 hours of exposure to the crude extracts and the isolated compounds where as in control group 100% survival was noted. In the initial stage of the experiment on Sitopbilus oryzae, after 30 minutes of exposure, schooling behavior was observed. After 30 minutes the weevils were dispersed there after towards the corners of the petridishes. After 1hour the locomotary movement of the weevils was restricted and these weevils could not be moved afterwards. The Periplaneta americana showed cleaning behavior at the initial stages of poisoning by rubbing their bodies with their legs or sides of the cages. At the later stages of poisoning Periplaneta americana shows incoordination and convulsion leading to paralysis. Gumbusia affinis showed hypersensitivity, an increased respiratory rate by indicating rapid operculum movement. The fishes were become restless and the movement of the body and operculum of fishes becomes lower down and the fishes were settled down at the bottom of the aquarium. At the final stages of intoxication after 24 hours the fishes were dead and found floating on the surface of the aquarium. The area of the brain of dead fishes was found red in color. From the above symptoms it was evident that the toxin found in the crud extract and the isolated compounds of Tetraodon fluviatilis may contains strong toxin.
Investigating Differentiation Ability of Induced Pluripotent Stem (Ips) Cell and Endometrial Stromal Cells (Enscs) Toward Pre-Oligodendrocytes using Growth Factors In Vitro
Authors: Younesi Behnam , Azarnia Mahnaz
Published: July 2017

ABSTRACT: Oligodendrocytes are types of cells in central neural system (CNS). Their main function is generation of Myelin sheath in CNS, this sheath insulates the Axons. Any disorder in the function of these cells leads to demyelination of neurons and causes neural disorders including multiple sclerosis (MS). Nowadays, cell therapy provides plenty of hope for cure of MS. So far it has used different sources such as stem cells or progenitor for cell therapy of neural system. But each of them had some limitations, for instance using neural stem cells requires certain amount of CNS tissue. Embryonic stem cells also introduced as another candidate for cell therapy but due to some moral problems, such as necessity to creating a Blastocyst, using these cells accompanied many limitations. In cell therapy, the most important factor is facility to acquiring stem cells. iPS cells are kinds of Induced Pluripotent Stem cells which directly created by transferring of 4 transcription factors: oct4, sox2, klf2, and c-Myc into the differentiated cells. iPS cells are like pluripotent embryonic stem cells although they do not require demolition of Blastocyte. Endometrial Stromal cells are kinds of mesenchyme or adult cells which have been proven in human and mice’s uterine endometrial and they are easy to access. Both of these types of cells can be appropriate candidates for cell therapy. In this research we use these two types of cells for differentiate to Oligodendrocytes and we are able to differentiate iPS cells which are from human's eye and also human Endometrial Stromal cells to pre-Oligodendrocytes. Also we can compare their differentiation ability. These cells can be used for transplanting in MS patients.
Analisa Shakemap dan Jenis Sesar Studi Kasus: Gempa bumi Terasa di Purworejo – Jawa Tengah
Authors: Wibowo Nugroho Budi , Nurhaci Dian Susri
Published: July 2017

Earthquake July 18, 2016 at 5:59:00 am occur on land 18 Km Northwest Purworejo. The earthquake measuring 3.6SR at a depth of 13 kilometers and was felt in Purworejo I - II MMI. This study aims to analyze the earthquake affected based on shakemap analysis and determine the type of fault used the initial motion of P waves that recorded on seismograph. Shakemap analysis using shakemap application at BMKG servers based on the accelerograph network BMKG. Meanwhile, an analysis the type of fault using focal application with data input signals from the seismograph SeisComP3 system. The highest values of peak ground acceleration (PGA) recorded in BPBD Kebumen’s station is 0.5075 gal (EW component), 0.5018 gal (NS component) and 0.3538 gal (UD component). Model shakemap for Purworejo earthquake felt I SIG (I-II MMI) in Purworejo, Kebumen and Banjarnegara. The models of focal mechanism are the first nodal obtained strike 321, dip 33, rake 95, and the second nodal obtained strike 135, dip 57, rake 87. Based on the distribution model compression axis (up or T) and dilatation (down or P), the type of fault is reverse fault. The epicenter of the Purworejo earthquake correlated with the Rebung faultin Purworejo.

Keyword: Shakemap, Focal Mechanism, PGA, Intensity, Earthquake, Fault.
Avaliação da Hering S.A.
Authors: Fukuzawa Roberto , Serra Ricardo Goulart
Published: July 2017

O caso apresenta o estudo sobre as decisões reais de investimento e de avaliação de empresa. A Hering S.A. é uma empresa de vestuário listada na BM&FBovespa. Por meio de informações públicas e artigos de jornais detalhados no texto, este caso (i) permite que os alunos analisem as decisões de investimento tomadas pelos grandes investidores que adquiriram ações ordinárias da empresa, ao mesmo tempo que (ii) oferece ao aluno o desafio de formular as premissas necessárias para avaliar a empresa com base em informações públicas como demonstrações contábeis, indicadores macroeconômicos e outras variáveis de mercado. O resultado obtido pelo aluno poderá ser confrontado na sala de aula para possível discussão sobre (i) as premissas utilizadas e (ii) os preços das ações calculados. Esta discussão pode explicitar os vieses decorrentes da motivação dos avaliadores na medida em que diferentes premissas podem ter sido adotadas e motivadas por diferentes interesses (comprador, vendedor, etc.).
Pesquisas Sensíveis em Administração e Organizações: Práticas e Desafios
Authors: Alcadipani Rafael , Cepellos Vanessa Martines
Published: July 2017

Pesquisas Sensíveis em Administração e Organizações: Práticas e Desafios
Taeniectomy pouch as neorectum after low rectal resection
Authors: Farag A , Mashhour AN , Elbarmelgi MY , Raslan MM , Abdelsalam AM , Mohsen AA
Published: July 2017

Background and purpose

The functional outcomes of incontinence and high stool frequency resulting from restorative surgery are often criticised. The aim of this study was to assess the taeniectomy pouch in comparison with other pouches described in the literature.

Material and methods

This was a prospective cohort study. All patients who were candidate for low rectal resection presenting to the colorectal unit at Cairo University hospitals during the period February 2013 to February 2015 were included in the study (90 patients). Safety and feasibility of the new technique were assessed, including operative time, leakage, postoperative urgency, incontinence, number of daily motions and difficulty in evacuation. These parameters were assessed clinically, by means of defecography and anorectal manometry.

Results

The mean age of patients was 49.6 years. Percentages of postoperative mortality and leakage were 2.2% and 3.4%, respectively. Mean operative time was 117 minutes. Mean numbers of daily motions were 3.04 and 1.52 at 3 and 12 months, respectively. Mean Wexner score for continence at 3 and 12 months were 3.21 and 1.32, respectively. Mean resting pressure was 51.63 mmHg, squeeze pressure was 130.42 mmHg and mean threshold volume was 118.68 ml.

Conclusions

Taeniectomy is a novel technique for pouch formation after low rectal resection, which can be used as an alternative to other pouches, especially the widely used transverse coloplasty.
FORMAÇÃO DOCENTE PARA A EDUCAÇÃO INFANTIL: UMA LEITURA DO CURSO DE PEDAGOGIA PÓS DIRETRIZES CURRICULARES
Authors: Nascimento Leandra Fernandes do , Cavalcante Maria Marina Dias
Published: July 2017

O presente estudo representa um recorte de um mais amplo realizado no Ceará, tendo como objetivo geral - analisar a organização curricular dos cursos de licenciatura em Pedagogia, enfocando no tratamento dado aos conhecimentos formativos para atender o futuro professor da Educação Infantil, em sete (7) Cursos de Pedagogia presenciais e um (1) EaD de uma Instituição de Ensino Superior multicampi. Caracteriza-se por ser uma pesquisa de abordagem qualitativa, realizada a partir da pesquisa documental - a Lei de Diretrizes e Bases da Educação Nacional - LDBEN 9394/1996, as Diretrizes Curriculares Nacionais para os cursos de Pedagogia de 2006 e a Resolução CNE/CP 2/2015 e as Matrizes Curriculares, as quais foram obtidas junto aos sites: do E-MEC e da instituição pesquisada. Os dados foram organizados no N* VIVO e analisados à luz dos conhecimentos teóricos relacionados à Formação Docente, Currículo e Educação Infantil. Os resultados apontam que a formação docente inicial dessa instituição precisa ser repensada, considerando não somente as exigências legais, mas que reveja seus conceitos, inclusive como instituição que oferece cursos presenciais. Nesse campo há que se refletir criticamente sobre os elementos oferecidos durante a formação do futuro professor para a Educação Infantil da educação básica brasileira.
PESQUISA E EXPERIÊNCIA: LITERATURA QUE PULSA NO MOVIMENTO DA ESCRITA
Authors: Da Silva Carla Clauber , Pillotto Silvia Sell Duarte
Published: July 2017

O presente artigo problematiza a não presença da literatura na escrita acadêmica em pesquisas, especialmente em dissertações e teses. O que se verifica é o silenciamento da literatura, pois se percebe sua utilização apenas como fragmentos poéticos na forma de epígrafes. Esse silenciamento se dá especialmente pelas políticas de linguagem estabelecidas para o registro e legitimação da produção de conhecimento. Portanto, o objetivo deste artigo é evidenciar que a literatura é uma escolha de escrita e uma experiência que afeta o pesquisador e a própria pesquisa, enquanto se lê, se escreve e se vive. De abordagem qualitativa, o referido texto debruça-se na leitura bibliográfica, dialogando com vários autores/pesquisadores que pensam a literatura como experiência. Dessa forma, a escrita e a leitura apropriadas para este artigo se traduzem em uma escrita ensaiada, uma vez que não se compreende apenas como registro de um conhecimento construído, mas, sobretudo, como experiência que atravessa as problematizações da pesquisa. Com o resultado desse estudo investigativo, pretende-se fortalecer o diálogo para outras possibilidades, entre elas, que a literatura ganhe maior espaço nas políticas de linguagem do mundo acadêmico para além do seu caráter ilustrativo, configurando-se também em conteúdo. Compreende-se, então, que a pesquisa em educação na sua dimensão qualitativa pode também abrigar outros sentidos, significados e experiências, tanto do pesquisador quanto dos seus interlocutores.
MOVIMENTOS E GESTOS DO CORPO INFANTIL NA PEDAGOGIA DE PROJETOS: TRAJETÓRIA METODOLÓGICA DE UMA PESQUISA COM CRIANÇAS
Authors: Monteiro Tatiane Lopes , Garanhani Marynelma Camargo
Published: July 2017

O objetivo deste estudo foi compreender como crianças utilizam o movimento do seu corpo para comunicarem suas aprendizagens. Para isto, selecionamos uma escola da rede particular de Curitiba, que por meio da pedagogia de projetos, considerava as crianças protagonistas de suas aprendizagens. Os instrumentos para a produção de dados da pesquisa foram: a observação participante, a entrevista em grupo e um recurso chamado JPEG converter, o qual possibilitou a transformação de vídeos em imagens fotográficas. A análise dos dados nos possibilitou identificar três tipos de movimentos na comunicação das crianças: o movimento aleatório do corpo infantil; o movimento do corpo como suporte da fala infantil e o movimento com intenção: o gesto infantil. Assim, o presente artigo tem a intenção de apresentar a trajetória metodológica da pesquisa, como também discussões e reflexões sobre o movimento do corpo infantil e os seus gestos no processo de comunicação de aprendizagens.
Potencial de produção de sementes de gramíneas para a implantação em gramados
Authors: Maximino Josiane Vargas de Oliveira , Machado Marco Aurélio Schiavon , Mittelmann Andréa , Pinheiro Eliézer Da Cunha , Pires Elizandro Da Silva , Longaray Mikael Bueno , De Souza Francisco Humberto Dubbern , Stumpf Elisabeth Regina Tempel
Published: July 2017

The Paspalum and Axonopus genera are among the main warm season grasses used for lawns. The seed propagation contributes to the decrease of the cost of establishment, besides maintaining the exact characteristics of the mother plant genotype, because they are apomictic species. The objective of this work was to evaluate the seed production potential of seventeen grass accesses of the species Paspalum notatum, P. lepton, P. lividum and Axonopus parodii. The experiment was conducted at Capão do Leão, Rio Grande do Sul State, Brazil, in a randomized block design, with four replications. The evaluated variables were: number of inflorescences per area, number of florets per inflorescence and seed production potential (SPP). In order to measure the seed production potential of the accesses, the equation proposed is: SPP = number of florets per inflorescence x number of inflorescences per m2 . There were year, access and interaction between years and accesses effect for the traits number of inflorescences per area and seed production potential. For the number of florets per inflorescence, there was no year effect. Potential production for the 2013/2014 harvest, ranged from 19,152.00 to 135,062.70 seeds m- ², with PN 09 of the P. notatum species standing out. In the 2014/2015 harvest, the seed production potential ranged from 9,973.75 to 81,536.75 seeds m- ², highlighting the access PN 11 of the species P. notatum. The accesses PN 11, PN 09, PN 10 and AP 01 were in the top third of the seed production potential ranking in the two harvests, and “grama-batatais” was in the lower third. There is genotype-environment interaction for all characteristics evaluated. However, there are accesses that show seed production potential consistently superior to the “grama-batatais” control, and have a greater potential for exploitation in the establishment of lawns by seeds.
Sumario
Authors: - -
Published: July 2017

Sumario
Sumary
Authors: - -
Published: July 2017

Sumary
La pedantocracia: el rostro moderno del despotismo. La mirada de John Stuart Mill
Authors: Pollitzer María
Published: July 2017

El objetivo del artículo es identificar y precisar los argumentos con los cuales John Stuart Mill construye su crítica a la pedantocracia, entendida como uno de los rostros con los cuales se presenta el despotismo en las sociedades «modernas» y «civilizadas». El término pedantocracia fue acuñado por Mill a comienzos de la década de 1840 para referirse a un peligro que, en su opinión, pocos percibían. Como ocurre con otras ideas-eje de su pensamiento, su reflexión sobre esta problemática se articula en torno al diálogo mantenido con pensadores provenientes del liberalismo continental (Tocqueville), del socialismo saint simoniano (d’Eichthal y Duveyrier), del positivismo (Comte) y de las filas románticas inglesas (Coleridge). Asimismo, es reflejo de su recepción de las obras de Platón y del renovado interés que suscitó la democracia ateniense a mediados del siglo XIX gracias a las obras de G. Grote.
Notas bibliográficas: La democracia que no es. Política y sociedad en la Argentina (1983-2016) de Hugo Quiroga
Authors: Mellado Virginia
Published: July 2017

LA DEMOCRACIA QUE NO ES.POLÍTICA Y SOCIEDAD EN LA ARGENTINA(1983-2016)de Hugo Quiroga,Edhasa, Ciudad Autónoma de Buenos Aires,2016 , 232 págs.
Progression of bifurcated family f type periodic orbits in the circular restricted three-body problem
Authors: Pushparaj Nishanth , Sharma Ram Krishan
Published: July 2017

Progression of f-type family of periodic orbits, their nature, stability and location nearer the smaller primary for different mass ratios in the framework of circular restricted three-body problem is studied using Poincaré surfaces of section. The orbits around the smaller primary are found to decrease in size with increase in Jacobian Constant C, and move very close towards the smaller primary. The orbit bifurcates into two orbits with the increase in C to 4.2. The two orbits that appear for this value of C belong to two adjacent separate families: one as direct orbit belonging to family g of periodic orbits and other one as retrograde orbit belonging to family f of periodic orbits. This bifurcation is interesting. These orbits increase in size with increase in mass ratio. The elliptic orbits found within the mass ratio 0 < µ ≤ 0.1 have eccentricity less than 0.2 and the orbits found above the mass ratio µ > 0.1 are elliptical orbits with eccentricity above 0.2. Deviations in the parameters: eccentricity, semi-major axis and time period of these orbits with solar radiation pressure q are computed in the frame work of photogravitational restricted Three-body problem in addition to the restricted three-body problem. These parameters are found to decrease with increase in the solar radiation pressure.
diode laser for excisional biopsy of pyogenic granuloma: a case series
Authors: Mahajan Gaurav , Gautam Aditi
Published: July 2017

Pyogenic granuloma is one of the inflammatory hyperplasias seen in the oral cavity. This term is a misnomer because the lesion is unrelated to infection and in reality arises in response to various stimuli such as low- grade local irritation, traumatic injury or hormonal factors. The clinical diagnosis of such lesion can be quite challenging because of its close resemblance to certain malignancies like peripheral giant cell granuloma, kaposi’s sarcoma, non hodgkin’s lymphoma etc. for excisional biopsy, options available are conventional surgical excision, electrocautery or lasers. In this report, we seek to highlight the therapeutic advantages achieved with a soft tissue diode laser in the treatment of pyogenic granuloma.
Recovery among People with Mental Illness (PMI) as Perceived by the Caregivers in Islamic Boarding School (IBS) in Indonesia
Authors: Sarjana Widodo , Fitrikasari Alifiati , Sari Sri Padma
Published: July 2017

Background: Mental hospitals as places to rehabilitation people with mental illness(PMI) in Indonesia are limited in numbers and do not meet with the number of PMI.The society may contribute in facilitating recovery and rehabilitation place for PMI including Islamic boarding school. Some Islamic boarding schools provide rehabilitation for PMI to help with recovery process. Recovery is an important aspect to assess the success of PMI rehabilitation. Nevertheless, there has been no study on Islamic boarding school’s caregivers’ perception on PMI recovery.Purpose: This study aims to explore recovery perception of caregivers treating PMI in Islamic boarding school and factors affecting recovery.Methods: Data are acquired from 19 caregivers from three Islamic boarding schools providing rehabilitation for PMI with Focus Group Discussion (FGD). The data analyzed using descriptive analysis.Result: Having a good communication is a recovery criterion that is mentioned themost by caregivers. There are three biggest factors affecting recovery based on the caregivers such as prayers or religion followed by social support from family and environment and also doing activities.Conclusion: The results may depict the PMI recovery so that the health care providers can provide interventions that can support the recovery process in PMI.
Changes in Sexuality of Castration-Resistant Prostate Cancer Patients under Hormone Therapy in Japan: A Case Study
Authors: Kashiwagi Yoshiyuki , Kakinohan Shige
Published: July 2017

Background: Hormone therapy is an important treatment for male patients with prostate cancer. However, it can produce changes in the genitalia and sexuality of the patients. Purpose: This study aimed to investigate the relations between changes in male genitalia and sexuality in the castration-resistant prostate cancer patients. It also proposed concrete interventions to ease pain and fear towards body image changes. Methods: This study used a descriptive qualitative design. The subjects were two castration-resistant prostate cancer patients undergoing chemotherapy and endocrine therapy. The data were collected through semi-structured interviews and analyzed using verbatim reports and content analysis. Results: The study indicated that the effects of hormone therapy treatment on the sexuality were largely categorized as: “surprises and anxieties about the shrinkage of male genitalia”, “masculinity loss”, “difficulty adapting the situation”, and “connection with others”. Conclusion: It became clear that the prostate cancer patients had pains not only for prognosis, but also for physical changes, relationship changes with others and sexuality changes through their treatments.
Surgical Site Infection among Women Post Cesarean Section: An Integrative Review
Authors: Novelia Shinta , Sae Sia Wipa , Songwathana Praneed
Published: July 2017

Background: Surgical site infection (SSI) in cesarean section (CS) is a major cause of prolonged hospital stay and resource consumption, and causes morbidity and mortality for the mother and the baby.Purpose: This literature review aimed to assess and identify risk factors, interventions, and prevention strategies of SSI for women post CS especially the obese women.Methods: An integrative literature review was conducted by employing the databases of PubMed, ProQuest, Science Direct, Wiley online library, and Google scholar from 1999 to 2015. This review identified the studies conducted either in women post-CS or obese women post CS.Results: A total of 58 articles were found, and 14 articles met the criteria. The risk factors of CS-SSI were classified into extrinsic and intrinsic factors. The intrinsic factors include limited mobility, poor nutrition, and comorbidity (diabetes) while the extrinsic factors include surgical technique, skin closure methods, prophylactic antibiotic, and the use of drains. Poor nutrition, diabetes, and limited mobility were the common factors found in obese women undergoing CS. Maintaining nutritional status and controlling blood glucose were proposed to prevent CS-SSI among obese women post-CS.Conclusions: Nurses should have adequate knowledge about the risk factors of CS-SSI to assess the risk factors of CS-SSI especially in obese women. The intervention of CS-SSI might need a bundle of interventions which consist of pre-operative and post-operative prevention strategies.
Maximal solutions for the ∞-eigenvalue problem
Authors: da Silva João Vitor , Rossi Julio D. , Salort Ariel M.
Published: July 2017

In this article we prove that the first eigenvalue of the

∞

{\infty}

-Laplacian

{

min
⁡

{

-

Δ
∞

⁢
v

,

|

∇
⁡
v

|

-

λ

1
,
∞

⁢

(
Ω
)

⁢
v

}

=
0

in 
⁢
Ω

,

v

=
0

on 
⁢

∂
⁡
Ω

,

\left\{\begin{aligned} \displaystyle\min\{-\Delta_{\infty}v,|\nabla v|-\lambda%
_{1,\infty}(\Omega)v\}&\displaystyle=0&&\displaystyle\text{in }\Omega,\\
\displaystyle v&\displaystyle=0&&\displaystyle\text{on }\partial\Omega,\end{%
aligned}\right.

has a unique (up to scalar multiplication) maximal solution.
This maximal solution can be obtained as the limit as

ℓ
↗
1

{\ell\nearrow 1}

of concave problems of the form

{

min
⁡

{

-

Δ
∞

⁢

v
ℓ

,

|

∇
⁡

v
ℓ

|

-

λ

1
,
∞

⁢

(
Ω
)

⁢

v
ℓ
ℓ

}

=
0

in 
⁢
Ω

,

v
ℓ

=
0

on 
⁢

∂
⁡
Ω

.

\left\{\begin{aligned} \displaystyle\min\{-\Delta_{\infty}v_{\ell},|\nabla v_{%
\ell}|-\lambda_{1,\infty}(\Omega)v_{\ell}^{\ell}\}&\displaystyle=0&&%
\displaystyle\text{in }\Omega,\\
\displaystyle v_{\ell}&\displaystyle=0&&\displaystyle\text{on }\partial\Omega.%
\end{aligned}\right.

In this way we obtain that the maximal eigenfunction is the unique one that is the limit of the sub-homogeneous problems
as happens for the usual eigenvalue problem for the p-Laplacian for a fixed

1
<
p
<
∞

{1<p<\infty}

.
Numerical analysis of two-parameter singularly perturbed boundary value problems via fitted splines
Authors: Ravi Kanth A. S. V. , Murali Mohan Kumar P.
Published: July 2017

In this paper, we consider two-parameter singularly perturbed boundary value problems via fitted splines.
We propose an exponentially fitting factor to the highest order derivative of the problem and discretize by parametric cubic spline functions on a uniform mesh.
An error analysis of the method is presented.
The efficiency of the method is demonstrated by test examples which support the theoretical results.
Snail species diversity impacts the infection patterns of Echinostoma spp.: Examples from field collected data
Authors: Zimmermann Michael R. , Luth Kyle E. , Esch Gerald W.
Published: July 2017

Rapid losses of biodiversity due to the changing landscape have spurred increased interest in the role of species diversity and disease risk. A leading hypothesis for the importance of biodiversity in disease reduction is the dilution effect, which suggests that increasing species diversity within a system decreases the risk of disease among the organisms inhabiting it. The role of species diversity in trematode infection was investigated using field studies from sites across the U.S. to examine the impact of snail diversity in the infection dynamics of both first and second intermediate larval stages of
Differentiation of Toxocara canis and Toxocara cati based on PCR-RFLP analyses of rDNA-ITS and mitochondrial cox1 and nad1 regions
Authors: Mikaeili Fattaneh , Mathis Alexander , Deplazes Peter , Mirhendi Hossein , Barazesh Afshin , Ebrahimi Sepideh , Kia Eshrat Beigom
Published: July 2017

The definitive genetic identification of
Molecular characterization and functional analysis of a glutathione peroxidase gene from Aphelenchoides besseyi (Nematoda: Aphelenchoididae)
Authors: Wang Bu-Yong , Wen Rong-Rong , Ma Ling
Published: July 2017

, the nematode agent of rice tip white disease, causes huge economic losses in almost all the rice-growing regions of the world. Glutathione peroxidase (GPx), an esophageal glands secretion protein, plays important roles in the parasitism, immune evasion, reproduction and pathogenesis of many plant-parasitic nematodes (PPNs). Therefore, GPx is a promising target for control