bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of solamargine as a cisplatin sensitizer through phenotypical screening in cisplatin-resistant NSCLC organoids
Authors: Han Yi , Shi Jianquan , Xu Ziwei , Zhang Yushan , Cao Xiaoqing , Yu Jianhua , Li Jie , Xu Shaofa
Published: August 2022

Although Cisplatin (DDP) is a widely used first-line chemotherapy medication, DDP resistance is one of the main causes of treatment failure in advanced lung cancer. Therefore, it is urgent to identify DDP sensitizers and investigate the underlying molecular mechanisms. Here we utilized DDP-resistant organoids established from tumor biopsies of patients with relapsed lung cancers. In this study, we identified Solamargine as a potential DDP sensitizer through screening a natural product library. Mechanically, Solamargine induced G0/G1-phase arrest and apoptosis in DDP-resistant lung cancer cell lines. Gene expression analysis and KEGG pathway analysis indicated that the hedgehog pathway was suppressed by Solamargine. Moreover, Gli responsive element (GRE) reporter gene assay and BODIPY-cyclopamine binding assay showed that Solamargine inhibited the hedgehog pathway via direct binding to SMO protein. Interestingly, Solamargine and DDP showed a synergetic effect in inhibiting DDP-resistant lung cancer cell lines. Taken together, our work herein revealed Solamargine as a hedgehog pathway inhibitor and DDP-sensitizer, which might provide a new direction for further treatment of advanced DDP-resistant lung cancer patients.
Case report: Long-term partial response of apatinib plus paclitaxel as second-line therapy in a patient with metastatic gastric cancer
Authors: Fu Shengya , Li Linjuan , Li Xiaofen , Wu Qiang , Wang Xiaohui , Huang Yan , Hu Haoyue , Cao Dan
Published: August 2022

Gastric cancer is the second most prevalent cancer and the second leading cause of cancer-related death in China. The prognosis of metastatic gastric cancer is poor with a median overall survival of 8–10 months. Apatinib, an oral small-molecule, selective vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, is approved as third-line or subsequent therapy for gastric cancer in China. Several recent small-scale studies and case reports showed that it may be great help in improvement of prognosis as second-line treatment in patients with advanced or metastatic gastric cancer. Here, we present a case of advanced gastric adenocarcinoma with multiple hepatic metastases who was treated with apatinib plus paclitaxel as second-line therapy, realized a long progression-free survival of 37 months. Until 29 January 2022, the disease remains an efficacy of partial response. We believe that the good outcome of this case is not an accident, because of the typically hyper-vascular of his liver metastases, the treatment toxicities of hypertension and proteinuria, all may be potential predictive biomarkers for anti-angiogenic treatments.
Distribution and metabolism of daidzein and its benzene sulfonates in vivo (in mice) based on MALDI-TOF MSI
Authors: Jiao Yanxiao , Li Xueqin , Tang Yao , Peng You , Chen Guisen , Wang Xin , Yan Long , Liu Huihui , Nie Zongxiu
Published: August 2022

Daidzein (D1) has been proved to be of great benefit to human health. More and more attention was paid to the metabolic process of D1. Most studies focused on the metabolites of D1 and analogs were determined through the excretion of animals and humans by traditional HPLC-MS, while their in situ distribution and metabolism in organs in vivo has not been reported. In our group, novel daidzein sulfonate derivatives were synthesized and confirmed to have excellent pharmaceutical properties. They exhibited good anti-inflammatory, inhibitory activities on human vascular smooth muscle cell proliferation and other bioactivities. Compared with traditional analytical methods, matrix-assisted laser desorption ionization time-of-flight mass spectrometry imaging (MALDI-TOF MSI) can directly analyze the distribution of compounds in tissues and organs. In this study, we investigate the in situ distribution and metabolism of D1 and its derivatives (DD2, DD3) in the organs of mice based on MALDI-TOF MSI for the first time. Trace prototype compounds were detected in the plasma 4 h after the intravenous injection of D1, DD2, and DD3. Seven phase I metabolites and seven phase II metabolites were detected. D1 sulfates were found in the plasma and in organs except the heart. The presence of D1 and DD3 monosulfates in the brain indicated that they could penetrate the blood–brain barrier. DD2 and DD3 could be hydrolyzed into D1 and their metabolic pathways were similar to those of D1. In addition, a ligand-receptor docking of D1 and DD2 with mitogen-activated protein kinase 8 (JNK1) was performed because of their significant anti-inflammatory activities through the JNK signaling pathway. It showed that the binding energy of DD2 with JNK1 was obviously lower than that of D1 which was consistent with their anti-inflammatory activities. It provided a theoretical basis for further validation of their anti-inflammatory mechanism at the protein level. In summary, the research will provide beneficial guidance for further pharmacological, toxicological studies and the clinical-use research of these compounds.
Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies
Authors: Wang Shuai , Luo Sean X. , Jie Jing , Li Dan , Liu Han , Song Lei
Published: August 2022

Background: The clinical efficiency of terpenoids in treating human acute lung injury (ALI) is yet to be determined. The lipopolysaccharide-induced rat model of ALI is a well-established and widely used experimental model for studying terpenoids’ effects on ALI. Using a systematic review and meta-analysis, the therapeutic efficiency of terpenoid administration on the lung wet-to-dry weight ratio in rats was investigated.

Methods: Using the Cochrane Library, Embase, and PubMed databases, a comprehensive literature search for studies evaluating the therapeutic efficacy of terpenoids on ALI in rats was conducted. The lung wet-to-dry weight ratio was extracted as the main outcome. The quality of the included studies was assessed using the Systematic Review Center for Laboratory Animal Experimentation’s risk of bias tool.

Results: In total, 16 studies were included in this meta-analysis. In general, terpenoids significantly lowered the lung wet-to-dry weight ratio when compared with the control vehicle (p = 0.0002; standardized mean difference (SMD): −0.16; 95% confidence interval (CI): −0.24, −0.08). Subgroup analysis revealed that low dose (≤10 μmol/kg) (p < 0.0001; SMD: −0.68; 95% CI: −1.02, −0.34), intraperitoneal injection (p = 0.0002; SMD: −0.43; 95% CI: −0.66, −0.20), diterpenoid (p = 0.004; SMD: −0.13; 95% CI: −0.23, −0.04), and triterpenoid (p = 0.04; SMD: −0.28; 95% CI: −0.54, −0.01) significantly lowered the lung wet-to-dry weight ratio when compared with the control vehicle.

Conclusion: A low dose of diterpenoid and triterpenoid administered intraperitoneally is effective in alleviating ALI. This systematic review and meta-analysis provides a valuable mirror for clinical research aiming at the advancement of terpenoids for preventive and therapeutic use.

Systematic Review Registration: CRD42022326779
Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review
Authors: Veiga Eduardo Carvalho de Arruda , Korkes Henri Augusto , Salomão Karina Bezerra , Cavalli Ricardo Carvalho
Published: August 2022

Background: Preeclampsia is a serious pregnancy complication that affects 5%–10% of the obstetric population.

Objective: To study inflammatory markers associated with preeclampsia.

Search Strategy: Searches of articles on the topic published over a 10-year period (2009–2019) were performed in three databases (PubMed, Cochrane, and Embase) using the keywords preeclampsia and inflammatory markers. The PubMed search using 10 years and humans as filters retrieved 124 articles. Using an advanced search strategy, 0 articles were identified in Embase and 10 articles in Cochrane. After screening and eligibility assessment, 13 articles were included in the systematic review and meta-analysis. Meta-analysis and quality assessment of the studies were performed using the Review Manager 5.3 program.

Results: For meta-analysis, women with preeclampsia were compared to control women, i.e., pregnancies without arterial hypertension. Leptin levels were significantly higher (p < 0.0002) in women with preeclampsia compared to controls. Total cholesterol was also significantly elevated in women with preeclampsia (p < 0.0001). There was no significant difference in HDL between groups, but women with preeclampsia had significantly increased LDL (p < 0.01). The same was observed for triglycerides, which were significantly increased in women with preeclampsia (p < 0.04) compared to controls. Analysis of TNF-alpha, an important inflammatory marker, showed higher levels in women with preeclampsia (p < 0.03) compared to controls. The same was observed for another important inflammatory marker, interleukin 6, which was significantly increased in women with preeclampsia (p < 0.0002). There was a significant increase of C-reactive protein in women with preeclampsia (p < 0.003) compared to controls.

Conclusion: Women with preeclampsia have increased levels of inflammatory markers compared to control women.
Development of male-larger sexual size dimorphism in a lizard: IGF1 peak long after sexual maturity overlaps with pronounced growth in males
Authors: Meter Brandon , Kratochvíl Lukáš , Kubička Lukáš , Starostová Zuzana
Published: August 2022

Squamate reptiles have been considered to be indeterminate growers for a long time. However, recent studies demonstrate that bone prolongation is stopped in many lizards by the closure of bone growth plates. This shift in the paradigm of lizard growth has important consequences for questions concerning the proximate causes of sexual size dimorphism. The traditional model of highly plastic and indeterminate growth would correspond more to a long-term action of a sex-specific growth regulator. On the other hand, determinate growth would be more consistent with a regulator acting in a sex-specific manner on the activity of bone growth plates operating during the phase when a dimorphism in size develops. We followed the growth of males and females of the male-larger Madagascar ground gecko (Paroedura picta) and monitored the activity of bone growth plates, gonad size, levels of steroids, expression of their receptors (AR, ESR1), and expression of genes from the insulin-like growth factor network (IGF1, IGF2, IGF1R, and IGF2R) in livers. Specifically, we measured gene expression before the onset of dimorphic growth, at the time when males have more active bone growth plates and sexual size dimorphism was clearly visible, and after a period of pronounced growth in both sexes. We found a significant spike in the expression of IGF1 in males around the time when dimorphism develops. This overexpression in males comes long after an increase in circulating testosterone levels and sexual maturation in males, and it might be suppressed by ovarian hormones in females. The results suggest that sexual size dimorphism in male-larger lizards can be caused by a positive effect of high levels of IGF1 on bone growth. The peak in IGF1 resembles the situation during the pubertal growth spurt in humans, but in lizards, it seems to be sex-specific and disconnected from sexual maturation.
Quantifying the germination response of Parthenium hysterophorus at various temperatures and water potentials by using population-based threshold model
Authors: Afzal Irfan , Akram Muhammad , Javed Talha , Ali Faryal , Kalaji Hazem M. , Wróbel Jacek , Telesiński Arkadiusz , Mojski Jacek , Ahmed Mohamed A. A.
Published: August 2022

Predicting the germination behavior of parthenium weed against different conditions of temperature and osmotic stress is helpful for studying the growth and development history of parthenium in different ecological contexts. Sustainable weed control strategies based on population-based threshold (PBT) models are profitable tools for crop planting date, herbicide application, and tillage operation time. To predict the emergence of parthenium by using thermal time (TT), hydrotime (HT), and hydrothermal time (HTT) analyses, seeds were exposed to varying constant temperatures (5, 10, 15, 20, 25, 30, 35, and 40°C) and water potentials (− 0.25, − 0.5, − 0.75, and − 1.0 MPa) under a controlled environment. Parthenium seeds showed better responses in terms of higher germination percentage and lower germination time at 20 and 25°C. The use of the germination modeling approach proposed the base temperature (7.2°C), optimum temperature (20°C), and ceiling temperature (42.8°C) for this weed. Moreover, germination behavior was also studied at different water potentials under different temperature regimes (10, 20, and 30°C). The HTT model predicted higher germination percentages (82.8 and 54.8%) of parthenium seeds at water potentials from 0 to −0.25 MPa, respectively, under a temperature of 20°C, and also identified a base water potential (Ψb(50) of − 0.54 MPa for germination. In conclusion, the use of the HTT modeling approach is helpful for predicting the emergence response of parthenium in a changing climate and ultimately supportive in time scheduling of parthenium weed management in cropping systems.
Responses Toward Injustice Shaped by Justice Sensitivity – Evidence From Germany
Authors: Bondü Rebecca , Holl Anna K. , Trommler Denny , Schmitt Manfred J.
Published: August 2022

Anger, indignation, guilt, rumination, victim compensation, and perpetrator punishment are considered primary responses associated with justice sensitivity (JS). However, injustice and high JS may predispose to further responses. We had N = 293 adults rate their JS, 17 potential responses toward 12 unjust scenarios from the victim’s, observer’s, beneficiary’s, and perpetrator’s perspectives, and several control variables. Unjust situations generally elicited many affective, cognitive, and behavioral responses. JS generally predisposed to strong affective responses toward injustice, including sadness, pity, disappointment, and helplessness. It impaired trivialization, victim-blaming, or justification, which may otherwise help cope with injustice. It predisposed to conflict solutions and victim compensation. Particularly victim and beneficiary JS had stronger effects in unjust situations from the corresponding perspective. These findings add to a better understanding of the main and interaction effects of unjust situations from different perspectives and the JS facets, differences between the JS facets, as well as the links between JS and behavior and well-being.
Scale development of apparel customization brand value: From the perspectives of practitioners and consumers
Authors: Li Hao , Gu Li-Wen , Liu Xiao-Gang , Ruan Yan-Wen
Published: August 2022

China apparel customization brands (CACBs) have been recently growing in massive quantities despite being in their infancy stages of brand value building. Although scholars have proven brand value’s importance in sustainable brand growth, studies on the specific context of CACBs are still limited. This research proposes a conceptual framework of CACBs’ brand value measured dimension based on previous studies and divides brand value into both general and specific dimensions. Accordingly, qualitative (semi-structured interviews) and quantitative (online survey) studies were conducted from the perspectives of practitioners and consumers. Ultimately, a scale of 30 items with nine dimensions was generated. Results reveal that brand association in the general dimensions and brand service in the special dimensions were the largest promoters of CACB brand value. Hence, practitioners should pay more attention to dimensions of cognitive conflicts. Practical suggestions for apparel customization marketers are proposed to build and enhance brand value.
Rater characteristics, response content, and scoring contexts: Decomposing the determinates of scoring accuracy
Authors: Palermo Corey
Published: August 2022

Raters may introduce construct-irrelevant variance when evaluating written responses to performance assessments, threatening the validity of students’ scores. Numerous factors in the rating process, including the content of students’ responses, the characteristics of raters, and the context in which the scoring occurs, are thought to influence the quality of raters’ scores. Despite considerable study of rater effects, little research has examined the relative impacts of the factors that influence rater accuracy. In practice, such integrated examinations are needed to afford evidence-based decisions of rater selection, training, and feedback. This study provides the first naturalistic, integrated examination of rater accuracy in a large-scale assessment program. Leveraging rater monitoring data from an English language arts (ELA) summative assessment program, I specified cross-classified, multilevel models via Bayesian (i.e., Markov chain Monte Carlo) estimation to decompose the impact of response content, rater characteristics, and scoring contexts on rater accuracy. Results showed relatively little variation in accuracy attributable to teams, items, and raters. Raters did not collectively exhibit differential accuracy over time, though there was significant variation in individual rater’s scoring accuracy from response to response and day to day. I found considerable variation in accuracy across responses, which was in part explained by text features and other measures of response content that influenced scoring difficulty. Some text features differentially influenced the difficulty of scoring research and writing content. Multiple measures of raters’ qualification performance predicted their scoring accuracy, but general rater background characteristics including experience and education did not. Site-based and remote raters demonstrated comparable accuracy, while evening-shift raters were slightly less accurate, on average, than day-shift raters. This naturalistic, integrated examination of rater accuracy extends previous research and provides implications for rater recruitment, training, monitoring, and feedback to improve human evaluation of written responses.
A developmental outlook on the role of cognition and emotions in youth volleyball and artistic gymnastics
Authors: Bisagno Elisa , Cadamuro Alessia , Rubichi Sandro , Robazza Claudio , Vitali Francesca
Published: August 2022

Developmental and cognitive psychology recently started to take an interest in the sports domain, exploring the role of either cognitive functions or emotions in youth sport. However, to the extent that cognition and emotions are inextricably linked, studying them jointly from a developmental perspective could inform on their interplay in determining performance in different sports. This research examined the role of general cognitive abilities, attentional style, and emotions (controlling for age and experience), in predicting performance in youth volleyball and artistic gymnastics. A total of 218 female participants, of which 114 volleyball players and 104 artistic gymnasts (11–17 years old) were administered two measures of working memory and six measures of executive functions (namely inhibition, updating, and shifting). They also completed an attentional style and an emotion-related questionnaire. For each volleyball player, an individual performance index based on every gesture performed during the games and controlled for the team performance was computed. As a measure of gymnasts’ performance, scores in 2017–2018 competitions were used. Regression analysis showed that the main predictor of the volleyball players’ performance (R2 = 0.23) was a working memory-updating factor (ß = 0.45, p = 0.001), together with experience (ß = 0.29, p = 0.030) and high-arousal unpleasant emotions (ß = 0.30, p = 0.029), which positively predicted performance. Experience (ß = 0.30, p = 0.011), age (ß = −0.036, p = 0.005) and high-arousal unpleasant emotions (ß = −0.27, p = 0.030) were the predictors of gymnasts’ performance (R2 = 0.25). These results represent a first step in understanding if and how youth female athletes of open- and closed-skills sports rely on different psychological abilities. This line of research could offer insight to practitioners regarding which psychological abilities could be more relevant to train depending on the type of sport.
Epistemic trust and personality functioning mediate the association between adverse childhood experiences and posttraumatic stress disorder and complex posttraumatic stress disorder in adulthood
Authors: Kampling Hanna , Kruse Johannes , Lampe Astrid , Nolte Tobias , Hettich Nora , Brähler Elmar , Sachser Cedric , Fegert Jörg M. , Gingelmaier Stephan , Fonagy Peter , Krakau Lina , Zara Sandra , Riedl David
Published: August 2022

Background

Adverse childhood experiences (ACEs) are associated with posttraumatic and complex posttraumatic stress disorder symptoms in adulthood (PTSD/cPTSD), as well as reduced epistemic trust (trust in the authenticity and personal relevance of interpersonally transmitted information) and impaired personality functioning. The present work aims to investigate the predictive value of epistemic trust—the capacity for social learning—on the mediating effect of personality functioning in the association of ACEs and PTSD/cPTSD.

Methods

We conducted structural equation modeling (SEM) based on representative data of the German population (N = 2,004). Personality functioning (OPD-SQS) was applied as a mediator between ACEs and PTSD/cPTSD (ITQ), while epistemic trust (ETMCQ) was added as predictor for OPD-SQS. TLI, CFI, and RMSEA (95%-CI) determined the models’ fit.

Results

N = 477 (23.8%) participants reported at least one ACE and n = 218 (10.9%) reported ≥4 ACEs. Fit indices were good for both PTSD (TLI = 0.96; CFI = 0.99; RMSEA = 0.06; 95%CI: 0.041–0.078) and cPTSD (TLI = 0.96; CFI = 0.99; RMSEA = 0.06; 95%CI: 0.043–0.081). ACEs were significantly associated with cPTSD (β = 0.44, p < 0.001) and PTSD (β = 0.29, p < 0.001), explaining 20 and 8% of its variance. Adding personality functioning as a mediator increased the explained variance of cPTSD and PTSD to 47 and 19% while the direct association between ACEs and cPTSD/PTSD decreased (β = 0.21/β = 0.17), thus, indicating a partial mediation. Including epistemic trust substantially increased the explained variance for personality functioning (41%) compared to ACEs as a single predictor (16%).

Conclusion

We add to previous research emphasizing the association between ACEs and PTSD/cPTSD symptoms. Offering insights on underlying mechanisms, we show that epistemic trust and personality functioning are relevant mediators. Since both are modifiable by psychotherapy, knowledge about the role of these constructs can inform research on psychotherapeutic interventions and prevention.
Post-traumatic growth trajectories among frontline healthcare workers during the COVID-19 pandemic: A three-wave follow-up study in mainland China
Authors: Yan Zhang , Wenbin Jiang , Bohan Lv , Qian Wu , Qianqian Li , Ruting Gu , Silong Gao , Miao Tuo , Huanting Li , Lili Wei
Published: August 2022

Objectives

The COVID-19 pandemic has taken a significant toll on people worldwide for more than 2 years. Previous studies have highlighted the negative effects of COVID-19 on the mental health of healthcare workers (HCWs) more than the positive changes, such as post-traumatic growth (PTG). Furthermore, most previous studies were cross-sectional surveys without follow-ups. This study draws on PTG follow-up during the COVID-19 outbreak at 12-month intervals for 2 years since 2020. The trajectories and baseline predictors were described.

Methods

A convenience sampling method was used to recruit frontline nurses or doctors at the COVID-19-designated hospital who were eligible for this study. A total of 565 HCWs completed the 2 years follow-up and were used for final data analysis. The latent growth mixture models (GMM) was used to identify subgroups of participants with different PTG trajectories. Multinomial logistic regression model was used to find predictors among sociodemographic characteristics and resilience at baseline.

Results

Four trajectory PTG types among HCWs were identified: ‘Persistent, “Steady increase”, “High with drop”, and “Fluctuated rise.” Comparing the “Persistent low” type, the other three categories were all associated with older age, higher education. Furthermore, “Persistent low” was also negatively associated with resilience at baseline.

Conclusion

The PTG of HCWs with different characteristics showed different trends over time. It is necessary to increase the measure frequency to understand the PTG status in different times. Improving HCW’s resilience could help improve staff PTG.
A longitudinal analysis of injury characteristics among elite and amateur tennis players at different tournaments from electronic newspaper reports
Authors: Musa Rabiu Muazu , Hassan Isyaku , Abdullah Mohamad Razali , Latiff Azmi Mohd Nazri , Abdul Majeed Anwar P. P. , Abu Osman Noor Azuan
Published: August 2022

The non-complexity of tennis, coupled with its health benefits, renders it appealing and encourages varying competitions at different levels of age, gender, and expertise. However, the rapid increase in the participation rates witnesses a surge in injury occurrences, prompting the need for in-depth analysis to facilitate immediate intervention. We employed a media content analysis technique in which tennis-associated articles published in the last 5 years were examined. A total of 207 news reports were gathered and screened for analysis. Subsequently, 71 articles were excluded from the study due to content duplications or summary updates of existing news articles, while 23 news articles were also excluded from the study due to inappropriateness. Finally, 113 news reports directly related to injury in tennis were coded and analyzed. We examined various types of injuries reported from the screened articles with respect to their status (fresh, recurrent, and recovery) across expertise levels i.e., elite, or amateur. Similarly, the incidence of injury occurrences based on the types of tournaments the players engage in was also investigated. A chi-square analysis was employed to achieve the objectives of the study. Occurrences of tennis-associated injuries are disseminated across expertise levels [χ(18)2 = 16.542; p = 0.555], with knee, hip, elbow, and shoulder injuries being highly prevalent in both elite and amateur players. Nevertheless, it was noted that elite players suffered a staggering 72.60% of injury-related problems, while amateur players sustained 27.40% of injuries. Moreover, the status of injury spreads based on types of tournaments [χ(4)2 = 3.374; p = 0.497], with higher occurrences of fresh and recurrent injuries, while low recovery rates were observed. The findings further demonstrated that injuries are sustained regardless of tournament types [χ(36)2 = 39.393; p = 0.321]. However, most of the injuries occurred at international tournaments (85%). Whereas, only 5.30% of the injuries occurred at national/regional tournaments while 9.70% were unidentified. It could be deduced from the findings of this investigation that elite players are more prone to injuries compared with amateur players. Furthermore, the most common tennis-related injuries affect the lower, trunk, and upper regions of the body, respectively. A large number of the reported tennis injuries are fresh and recurrent, with a few recoveries. The international tennis tournaments are highly attributed to injury occurrences as opposed to the national/regional tournaments. The application of the media-based data mining technique is non-trivial in projecting injury-related problems that could be used to facilitate the development of an injury index peculiar to the tennis sport for prompt intervention.
The association between neurodevelopmental and behavioral problems and tobacco smoke exposure among 3–17 years old children
Authors: Gao Yu , Wang Tong , Duan Zhizhen , Pu Yuepu , Zhang Juan
Published: August 2022

Children being exposed to tobacco smoke can lead to poor developmental and behavioral problems. We aimed to explore the correlation between neurodevelopmental and behavioral problems (NBPs) and tobacco smoke exposure (TSE) among children aged 3–17 years. In this study, data were obtained from the 2018–2019 U.S. National Survey of Children's Health (NSCH). Children in the range of 3–17 years old were taken as the research subjects, and their parents were surveyed through questionnaires. TSE status was defined as one of three groups: no tobacco smoke exposure (no TSE), someone smoking but not inside the house (no home TSE), and someone smoking inside the house (home TSE). NBPs mainly included behavioral or conduct problems, intellectual disability, learning disability, speech or other language disorders, and developmental delay. We used the sampling weights provided by the NSCH to weight the data in order to obtain an unbiased population estimate. One-way ANOVA and Chi-square tests were performed to examine the difference of each variable. Logistic regression analysis and stratified analysis were carried out to investigate the association between NBPs and TSE. A total of 48,783 children were included in this study, with an average age of 10.1 years. In total 17.9% of all the participants were preschool children, 35.1% were school-age children, and 47.0% were school-age adolescents. More than 85.0% of children lived with no TSE. Over 90.0% of children were healthy in each NBP. Children living with home TSE and no home TSE showed significant adjusted odds ratios (aORs) compared with no TSE in four NBPs besides intellectual disability. The stratified analysis found aORs were higher for NBPs in preschool children compared to the school-age children and school-age adolescents. Male children living with home TSE showed higher aORs in moderate/severe NBP conditions. Our study indicated it is necessary to protect the health of young children from TSE by intervention measures.
The relations between mental well-being and burnout in medical staff during the COVID-19 pandemic: A network analysis
Authors: Chen Chen , Li Fengzhan , Liu Chang , Li Kuiliang , Yang Qun , Ren Lei
Published: August 2022

Background

Although poor mental well-being (MW) has been documented among individuals experiencing burnout during the coronavirus-19 (COVID-19) pandemic, little is known about the complex interrelationship between different components of MW and burnout. This study investigates this relationship among medical staff during the COVID-19 pandemic through network analysis.

Methods

A total of 420 medical staff were recruited for this study. Components of MW were measured by the 14-item Warwick-Edinburgh Mental Well-being Scale (WEMWBS), and components of burnout were measured by a 15-item Maslach Burnout Inventory-General Survey (MBI-GS) Questionnaire. Network structure was constructed via network analysis. Bridge variables were identified via the bridge centrality index.

Results

The edges across two communities (i.e., MW community and burnout community) are almost negative, such as edge MW2 (“Useful”) – B14 (“Worthwhile”) and edge MW1 (“Optimistic about future”) – B13 (“Happy”). The edges within each community are nearly positive. In the MW community, components MW1 (“Optimistic about future”) and MW6 (“Dealing with problems”) have the lowest bridge centrality. And in the community of burnout, components B13 (“Happy”) and B14 (“Worthwhile”) have the lowest bridge expected influence.

Conclusion

We present the first study to apply the network approach to model the potential pathways between distinct components of MW and burnout. Our findings suggest that promoting optimistic attitudes and problem-solving skills may help reduce burnout among medical staff during the pandemic.
An efficient modular framework for automatic LIONC classification of MedIMG using unified medical language
Authors: Bhatia Surbhi , Alojail Mohammed , Sengan Sudhakar , Dadheech Pankaj
Published: August 2022

Handwritten prescriptions and radiological reports: doctors use handwritten prescriptions and radiological reports to give drugs to patients who have illnesses, injuries, or other problems. Clinical text data, like physician prescription visuals and radiology reports, should be labelled with specific information such as disease type, features, and anatomical location for more effective use. The semantic annotation of vast collections of biological and biomedical texts, like scientific papers, medical reports, and general practitioner observations, has lately been examined by doctors and scientists. By identifying and disambiguating references to biomedical concepts in texts, medical semantics annotators could generate such annotations automatically. For Medical Images (MedIMG), we provide a methodology for learning an effective holistic representation (handwritten word pictures as well as radiology reports). Deep Learning (DL) methods have recently gained much interest for their capacity to achieve expert-level accuracy in automated MedIMG analysis. We discovered that tasks requiring significant responsive fields are ideal for downscaled input images that are qualitatively verified by examining functional, responsive areas and class activating maps for training models. This article focuses on the following contributions: (a) Information Extraction from Narrative MedImages, (b) Automatic categorisation on image resolution with an impact on MedIMG, and (c) Hybrid Model to Predictions of Named Entity Recognition utilising RNN + LSTM + GRM that perform admirably in every trainee for every input purpose. At the same time, supplying understandable scale weight implies that such multi-scale structures are also crucial for extracting information from high-resolution MedIMG. A portion of the reports (30%) are manually evaluated by trained physicians, while the rest were automatically categorised using deep supervised training models based on attention mechanisms and supplied with test reports. MetaMapLite proved recall and precision, but also an F1-score equivalent for primary biomedicine text search techniques and medical text examination on many databases of MedIMG. In addition to implementing as well as getting the requirements for MedIMG, the article explores the quality of medical data by using DL techniques for reaching large-scale labelled clinical data and also the significance of their real-time efforts in the biomedical study that have played an instrumental role in its extramural diffusion and global appeal.
Research on older people's health information search behavior based on risk perception in social networks—A case study in China during COVID-19
Authors: Zhang Chi , Liao Wei Fang , Ma Yi Ming , Liang Chang Yong
Published: August 2022

Objective

COVID-19 has caused great loss of human life and livelihoods. The dissemination of health information in online social networks increased during the pandemic's quarantine. Older people are the most vulnerable group in sudden public health emergencies, and they have the disadvantage of infection rates and online search for health information. This study explores the relationship between the health risk perception and health information search behavior of older people in social networks, to help them make better use of the positive role of social networks in public health emergencies.

Method

Based on the Risk Information Search and Processing model, and in the specific context of COVID-19, this study redefines health risk perception as a second-order construct of four first-order factors (perceived probability, perceived severity, perceived controllability, and perceived familiarity), and constructs a research model of the health risk perception and health information search behavior of older people. An online survey of people over 55 years old was conducted through convenience sampling in China from February 2020 to March 2020.

Results

A total of 646 older adults completed the survey. The structural equation model showed that health risk perception is a second-order factor (H1), that health risk perception has significant positive effects on health information search behavior (H2: β = 0.470, T = 11.577, P < 0.001), and that health risk perception has significant positive effects on affective response (H3: β = 0.536, T = 17.356, P < 0.001). In addition, affective response has a significant positive mediating effect on information sufficiency (H4: β = 0.435, T = 12.231, P < 0.001), and information sufficiency has a significant positive mediating effect on health information search behavior (H5: β = 0.136, T = 3.081, P = 0.002).

Conclusion

The study results indicate that the health risk perception of older people during the COVID-19 outbreak not only directly affected their health information search behavior, but also had an indirect impact on their health information search behavior by affecting affective response and information sufficiency.
Building PRM in sub-Saharan Africa
Authors: Tannor Abena Yeboaa , Nelson Mary Elizabeth S. , Steere Hannah K. , Quao Benedict Okoe , Haig Andrew J.
Published: August 2022

It is estimated that about 50% of people in low- and middle- income countries who require rehabilitation do not get it. Multidisciplinary rehabilitation services led by Physical and Rehabilitation Medicine (PRM) physicians have been shown to improve functioning, independence and the quality of life of persons with reduced functioning or disability. However, there is a dearth of PRM physicians in low to middle income countries (LMICs), particularly in sub-Saharan Africa. One potential solution to this lack of specialists is the establishment of PRM training programs, which are currently lacking. The International Rehabilitation Forum (IRF) developed and implemented a fellowship program to train physicians in rehabilitation medicine and has been successful in Ghana, Ethiopia and Cameroon, all LMICs in sub-Saharan Africa. However, ongoing challenges include inadequate PRM trainers, availability of logistics and services for hands on experience, and funding. The fellowship program has a promising future and an ultimate goal of having locally trained fellows leading the program and expanding it to other LMICs. There has however been no publication of the process followed to achieve this or of a similar process undertaken anywhere in Africa. The process followed in this publication highlights the journey from engaging stakeholders to the admission of new and current fellows in training.
Individualized total laparoscopic surgery based on 3D remodeling for portal hypertension: A single surgical team experience
Authors: Jikai Yin , Dong Wang , Li Zhang , Rui Dong , Tao Yang , Bo Huang , Yibo Sun , Shixiong Lei , Qiangshan Bai , Jianguo Lu
Published: August 2022

Background and aims

Portal hypertension (PHT) is common in end-stage cirrhosis, and variceal bleeding is the main complication associated with mortality. Surgery is usually performed in patients with PHT with a high risk of variceal bleeding in China. This study aimed to introduce an individualized and precise total laparoscopic surgical procedure based on 3D remodeling for PHT.

Methods

From March 2013 to December 2018, 146 patients with cirrhotic PHT underwent a laparoscopic surgical procedure in our department. An individualized 3D remodeling evaluation was carried out for surgical planning.

Results

The operation time was 319.96 ± 91.53 min. Eight of 146 patients were converted to open surgery. Acute portal vein system thrombosis occurred in 10 patients (6.85%). During the first year, 11 patients (8.15%) experienced rebleeding and two (1.48%) died. 18 patients (13.33%) experienced rebleeding and three died, giving a 3-year mortality rate of 3.66%. Compared with preoperatively, the portal vein showed significant postoperative decreases in diameter, flow velocity, and flow amount, while the hepatic artery showed significant postoperative increases in diameter, flow velocity, and flow amount. A 3D liver volume evaluation found that 19 of 21 patients had a significantly increased liver volume postoperatively, and a significantly decreased MELD score.

Conclusion

This retrospective study introduced a safe, feasible, and effective individualized surgical procedure. Our results show that this surgical treatment may not only act as an effective symptomatic treatment for PHT to prevent esophageal and gastric hemorrhage, but also as an etiological treatment to increase liver function and long-term survival.
The impact of intraoperative “Nerve Monitoring” in a tertiary referral center for thyroid and parathyroid surgery
Authors: Princi Pietro , Gallo Gaetano , Tempera Serena Elisa , Umbriano Antonio , Goglia Marta , Andreoli Federica , Nigro Casimiro
Published: August 2022

The most fearsome complication in thyroid surgery is the temporary or definitive recurrent laryngeal nerve (RLN) injury. The aim of our study was to evaluate the impact of intraoperative neuromonitoring (IONM) on postoperative outcomes after thyroid and parathyroid surgery. From October 2014 to February 2016, a total of 80 consecutive patients, with high risk of RLN injuries, underwent thyroid and parathyroid surgery. They were divided in two groups (IONM group and control group), depending on whether neuromonitoring was used or not. We used the Nerve Integrity Monitoring System (NIM)-Response 3.0® (Medtronic Xomed®). The operation time (p = 0.014). and the length of hospital stay (LOS) (p = 0.14) were shorter in the IONM group. Overall mean follow-up was 96.7 ± 14.3 months. The rate of transient RLN palsy was 2.6% in IONM group and 2.5% in the control group (p = not significant). Only one case of definitive RLN injury was reported in control group. No differences were reported between the two groups in terms of temporary or definitive RLN injury. Routine use of IOMN increases the surgery cost, but overall, it leads to long-term cost savings thanks to the reduction of both operating times (106.3 ± 38.7 vs 128.1 ± 39.3, p: 0.01) and LOS (3.2 ± 1.5 vs 3.7 ± 1.5 days, p = 0.14). Anatomical visualization of RLN remains the gold standard in thyroid and parathyroid surgery. Nevertheless, IONM is proved to be a valid help without the ambition to replace surgeon's experience.
Immobilization of Captive Kulans (Equus hemionus kulan) Without Using Ultrapotent Opioids
Authors: Bohner Julia , Painer Johanna , Bakker Denyse , Haw Anna Jean , Rauch Hanna , Greunz Eva Maria , Egner Beate , Goeritz Frank
Published: August 2022

Etorphine is widely used in zoological medicine for the immobilization of large herbivores. All reported immobilization protocols for kulans use etorphine as the primary immobilizing agent. However, etorphine can trigger severe side effects and is highly toxic for humans, its availability is occasionally limited for use in wildlife medicine. Therefore, two different alpha-2 agonist-based protocols for the general anesthesia of kulans were investigated and compared with the standard etorphine immobilization. In total, 21 immobilizations were performed within the scope of routine husbandry management at the Serengeti-Park Hodenhagen. Kulans were darted using a ketamine–medetomidine–midazolam–butorphanol (KMMB) protocol (n= 8, treatment group (TG) 1), a tiletamine–zolazepam–medetomidine–butorphanol (TZMB) protocol (n= 7, treatment group (TG) 2), or an etorphine–acepromazine–detomidine–butorphanol (EADB) protocol (n= 6, control group). Vital parameters included heart rate, respiratory rate, arterial blood pressure (invasive), end tidal CO2(etCO2), electromyography and core body temperature, which were all assessed every 10 min. For blood gas analysis, arterial samples were collected 15, 30, 45 and 60 min after induction. Subjective measures of quality and efficacy included quality of induction, immobilization, and recovery. Time to recumbency was longer for TG 1 (9.00 ± 1.67 min) and TG 2 (10.43 ± 1.79 min) compared to the induction times in the control group (5.33 ± 1.93 min). Treatment group protocols resulted in excellent muscle relaxation, normoxemia and normocapnia. Lower pulse rates combined with systolic arterial hypertension were detected in the alpha-2 agonist-based protocols. However, only in TZMB-immobilized kulans, sustained severe systolic arterial hypertension was observed, with significantly higher values than in the TG 1 and the normotensive control group. At 60 min following induction, medetomidine and detomidine were antagonized with atipamezole IM (5 mg/mg medetomidine or 2 mg/mg detomidine), etorphine and butorphanol with naltrexone IV (2 mg/mg butorphanol or 50 mg/mg etorphine), and midazolam and zolazepam with flumazenil IV (0.3 mg per animal). All three combinations provided smooth and rapid recoveries. To conclude, the investigated treatment protocols (KMMB and TZMB) provided a safe and efficient general anesthesia in kulans with significantly better muscle relaxation, higher respiration rates and improved arterial oxygenation compared with the immobilizations of the control group. However, the control group (EADB) showed faster recoveries. Therefore, EADB is recommended for ultra-short immobilizations (e.g., microchipping and collaring), especially with free-ranging kulans where individual recovery is uncertain, whereas the investigated treatment protocols are recommended for prolonged medical procedures on captive kulans.
Antibiotic resistance, biofilm formation, and virulence factors of isolates of staphylococcus pseudintermedius from healthy dogs and dogs with keratitis
Authors: Wang Zhihao , Guo Long , Li Jun , Li Jianji , Cui Luying , Dong Junsheng , Meng Xia , Qian Chen , Wang Heng
Published: August 2022

Canine bacterial keratitis is a common infection that can potentially threaten vision. Staphylococcus pseudintermedius (S. pseudintermedius) is an opportunistic pathogen that has been isolated from the canine conjunctival sac but there are only a few reports on the role of this bacterium in canine keratitis. This study focused on the distribution rate of S. pseudintermedius in the canine conjunctival sac, and the antibiotic resistance, biofilm-producing ability, and dissemination of virulence factors in strains of S. pseudintermedius isolated from healthy dogs and dogs with keratitis. The study included 35 healthy dogs and 40 dogs with keratitis. Bacterial species were confirmed by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI–TOF MS). Strains of S. pseudintermedius were screened for resistance against nine different antibiotics by the Kirby–Bauer assay. The ability to produce biofilm was investigated by microtiter plate assay (MtP) and amplification of icaA and icaD genes. Virulence factors in the strains were also evaluated. A total of 132 aerobic bacteria were isolated from the 119 samples in the study. Among them, 67 bacterial strains were isolated from 70 eyes of healthy dogs, and 65 bacterial strains were isolated from 49 eyes of dogs with keratitis. The prevalence of S. pseudintermedius, which was the most frequent bacterial isolate in both the groups, was 20.9% in the healthy group and 23.08% in the keratitis group. Most of the isolates of S. pseudintermedius were sensitive to rifampin (96.6%), oxacillin (100%), and neomycin (96.6%), and resistant to tetracycline (96.6%). Virulence factors such as lip (96.6%), hlgB (96.6%), and hlgA (96.6%) were found in most of the isolates, and 89.66% of isolates were classed as biofilm producers. In conclusion, S. pseudintermedius was the common bacterium in the conjunctivital sac of the healthy dogs and dogs with keratitis in Yangzhou, China, and the presence of virulence factors and biofilm-formation ability were high in the strains isolated from the dogs with keratitis.