bluuebunny/crossref_metadata_2025 huggingface dataset:
Perioperative predictive factors of failure to rescue following highly advanced hepatobiliary- pancreatic surgery
Authors: Fukada Masahiro , Murase Katsutoshi , Higashi Toshiya , Yasufuku Itaru , Sato Yuta , Tajima Jesse Yu , Kiyama Shigeru , Tanaka Yoshihiro , Okumura Naoki , Matsuhashi Nobuhisa
Published: June 2023

Background
Failure to rescue (FTR), defined as a postoperative complication leading to mortality, is a recently described outcome metric used to evaluate treatment quality. However, the predictive factors for FTR, particularly following highly advanced hepatobiliary-pancreatic surgery (HBPS), have not been adequately investigated. This study aimed to identify perioperative predictive factors for FTR following highly advanced HBPS.
Methods
This single-institution retrospective study involved 177 patients at Gifu University Hospital who developed severe postoperative complications (Clavien-Dindo classification ≥ grade 3a) between 2010 and 2022 following highly advanced HBPS. Logistic regression analysis was used to identify pre-, intra-, and postoperative risks of FTR.
Results
Nine postoperative mortalities occurred during the study period (overall mortality rate, 1.3% [9/686]; FTR rate, 5.1% [9/177]). Univariate analysis indicated that comorbid liver disease, intraoperative blood loss, intraoperative blood transfusion, postoperative liver failure, postoperative respiratory failure, and postoperative bleeding significantly correlated with FTR. Multivariate analysis indicated that intraoperative blood loss > 1600 mL (odds ratio [OR] 1.12e + 9; 95% confidence interval [CI] 34.87–; p < 0.001) and postoperative respiratory failure (OR 2.29e + 8; 95% CI 15.53–; p < 0.001) were independently associated with FTR.
Conclusions
FTR was found to be associated with hospital-related factors and may be associated with perioperative factors. Prevention of massive intraoperative blood loss and postoperative respiratory failure may decrease FTR rates.
Patient characteristics associated with hospital admission or antiarrhythmic medication changes after emergency department evaluation of supraventricular tachycardia
Authors: Schmucker Kyle A , Morris Caroline S , Tisherman Robert T , Manole Mioara , Arora Guarav , Dunnick Jennifer
Published: June 2023

Background
Supraventricular tachycardia (SVT) is a relatively frequent diagnosis in the pediatric emergency department (ED). However, there are no consensus guidelines for ED disposition, and there are limited data on ED outcomes. Better understanding of those who are admitted or have antiarrhythmic medication changes may avoid potentially unnecessary transfers or admissions. Our objective was to identify patient factors associated with discharge from the emergency department without medication initiation or modification after management of SVT in the pediatric ED.
Design/Methods
A retrospective review of children aged 0-18 years seen in the emergency department for SVT was conducted using electronic medical record data over a ten-year period at a single academic tertiary children’s hospital. Patients with congenital cardiac disease or prior cardiac surgeries were excluded. Multivariable logistic regression analysis was used to determine association between patient factors of interest and the primary outcome of admission and secondary outcome of change to antiarrhythmic medications.
Results
We analyzed 197 patients encounters. The mean age was 7 years. Of these 104 (52.8%) were admitted to the hospital or discharged with antiarrhythmic medication changes. This primary outcome was associated with younger age (aOR 0.77, 95% CI 0.67-0.86), history of pre-excitation (aOR 5.82, 95% CI 2.01-18.8), intercurrent illness (aOR 3.75, 95% CI 1.27-12.1), number of adenosine doses prior to arrival (aOR 5.45, 95% CI 1.55-22.3), and in-person cardiology consultation (aOR 6.42, 95% CI 2.43-19.4).
Conclusions
Nearly half of children treated in a pediatric ED for SVT are discharged without changes in medications. We identified patient factors associated with hospital admission or antiarrhythmic medication changes. These factors represent high value care and can be assessed when considering transfer from a referring facility. Risk stratification using these patient characteristics may reduce potentially avoidable transfers and admissions.
Sustainable Chemically Modified Mater-Bi/Poly(ε-caprolactone)/Cellulose Biocomposites: Looking at the Bulk through the Surface
Authors: Hejna Aleksander , Barczewski Mateusz , Kosmela Paulina , Mysiukiewicz Olga , Tercjak Agnieszka , Piasecki Adam , Saeb Mohammad Reza , Szostak Marek
Published: June 2023

Sustainable polymer composites are progressively under development in a technological paradigm shift from "just use more and more" to "convert into value-added products". The bio-based blends based on Mater-Bi bio-plastic (A) and poly(ε-caprolactone) (B), at a weight ratio of 70:30 (A:B) were developed, followed by the addition of UFC100 cellulose (C) filler to yield 70/30 (w/w) (A:B)/C sustainable biocomposites. The effects of chemical modification of C with three diisocyanates, i.e., hexamethylene diisocyanate (HDI), methylene bisphenyl isocyanate (MDI), or toluene diisocyanate (TDI) on the surface properties of biocomposites was evaluated by water contact angle and surface roughness detected by atomic force microscopy (AFM). Biocomposites containing C modified with HDI, MDI, or TDI revealed contact angle values of 93.5°, 97.7°, and 92.4°, respectively, compared to 88.5° for reference blend, indicating enlarged hydrophobicity window. This action was further approved by increased fracture surface roughness and miscibility detected by microscopic observation (scanning electron microscopy (SEM) and AFM) and in-depth oscillatory rheological evaluation. Correspondingly, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) analyses showed more residue and higher melting temperatures for biocomposites, more promisingly with MDI and TDI modifiers. In conclusion, either incorporation or diisocyanate modification of C affects both surface and bulk properties.
HUMOUR AS A COUNTER ISLAMIST DISCOURSE
Authors: Nisa Khalimatu
Published: June 2023

This article addresses counter-Islamist discourses by NU Garis Lucu (NU’s Funny Brigade) through its social media accounts. Instead of a clear-cut theological debates, NU Garis Lucu offers humour as method to counter attack Islamit’s arguments through its social-media activism. Using a discourse analysis approach, this article examines tweets of the NU Garis Lucu’s during the course of 2015-2020. It further reveals the account strategies to counter attack Islamist’s discourse which include questioning the legitimacy of the religious authority of Islamist groups, promoting religious moderation, supporting democracy as an ideal political system, promoting ‘smiling’ Islam, and putting to an end religious polarization.
Quantum computation with cat qubits
Authors: Guillaud Jérémie , Cohen Joachim , Mirrahimi Mazyar
Published: June 2023

These are the lecture notes from the 2019 Les Houches Summer School on “Quantum Information Machines”. After a brief introduction to quantum error correction and bosonic codes, we focus on the case of cat qubits stabilized by a nonlinear multi-photon driven dissipation process. We argue that such a system can be seen as a self-correcting qubit where bit-flip errors are robustly and exponentially suppressed. Next, we provide some experimental directions to engineer such a multi-photon driven dissipation process with superconducting circuits. Finally, we analyze various logical gates that can be implemented without re-introducing bit-flip errors. This set of bias-preserving gates pave the way towards a hardware-efficient and fault-tolerant quantum processor.
EFFECT OF KANGAROO MOTHER CARE ON NEURODEVELOPMENTAL OUTCOME OF BABIES WITH HIE
Authors:   Resident of Department of Paediatrics., Devika Dasari , R. Premalatha ,   HOD &Professor of Paediatrics, Principal - MVJ Medical College and Research Hospital.
Published: June 2023

Intrapartum asphyxia and consequential Hypoxic Ischemic Encephalopathy (HIE) are a common cause of potentially avoidable neonatal brain injury and mortality.HIE occurs in 1.5 per 1000 live births and 2.3 â€“ 26.2 per 1000 live births in developed and developing countries respectively(3,4). Approximately 50% of neonates with severe HIE die, and survivors develop serious and devastating complications including mental retardation, epilepsy, and cerebral palsy. Kangaroo mother care (KMC) is evidenceâ€based technology that centers on the mother as the primary provider of heat and stimulation resulting in an array of benefits for the newborn. But the data on its effect on neurodevelopmental outcome is very limited especially on babies born with HIE.This study was conducted to compare the effects of KMC and conventional method of care (CMC) on the neurodevelopment of the newborns born with HIE.
PRIMARY PARASPINAL LEIOMYOSARCOMA INVADING THE DORSAL SPINAL CANAL:A CASE REPORT AND REVIEW OF THE LITERATURE
Authors:   Department of Neurosurgery, Military Hospital Moulay Ismail - Meknes., a AbdelilahIdir , Elmajdoub Youssef ,   Department of Neurosurgery, Military Hospital Moulay Ismail - Meknes., Okacha Naama ,   Department of Neurosurgery, Military Hospital Moulay Ismail - Meknes., Boulahroud Omar ,   Department of Neurosurgery, Military Hospital Moulay Ismail - Meknes.
Published: June 2023

Leiomyosarcoma (LMS) is one of the most common subtypes of soft tissue sarcoma in adults and can occur in almost any part of the body, which presents a high propensity to metastasize to various locations. Primary leiomyosarcomas of the paraspinal soft tissues are exceedingly rare. We report a case of a primary leiomyosarcoma of the dorsal paraspinal musculature invading the spinal canal in a 36-year-old man, successfully treated with surgery.
LEXODE DES JEUNES HOMMES DE KABADIO EN CASAMANCE DANS LE SUD DU SENEGAL
Authors:   Enseignant-Chercheur, Universite Assane Seck de Ziguinchor Laboratoire de Recherche en Sciences Economiques et Sociales (LARSES), Senegal., Ngom Abdoulaye , Heurtault Jeanne ,   Chercheuse Independante en Anthropologie Sociale, DiplÃ´mee en Ethnologie et Anthropologie Sociale Ã  lEHESS de Paris, France.
Published: June 2023

From the village of Kabadio (Casamance, Senegal), of work that will allow them to support themselves and their families, as well as gain social prestige. The French association Permakabadiois trying to slow down this exodus phenomenon through the activity of permaculture. What are the factors that push these young people to leave their village? And what role does the association play in this desire to leave? Based on a series of interviews and long-term observations in the village of Kabadio, the article will attempt to answer these questions.
LOXYTOCINE: ALTERNATIVE THERAPEUTIQUE DANS LES HEMORRAGIES DIGESTIVES HAUTES VARIQUEUSES A ANTANANARIVO (MADAGASCAR)?
Authors:   Service de Reanimation Chirurgicale, Centre Hospitalier Universitaire Joseph RavoahangyAndrianavalona, Ampefiloha, 101 Antananarivo Madagascar., Nadia Marie Philibertine Rahanitriniaina , Aurelia Rakotondrainibe ,   Service de Reanimation Chirurgicale, Centre Hospitalier Universitaire Joseph RavoahangyAndrianavalona, Ampefiloha, 101 Antananarivo Madagascar., Fabien Raharimanana ,   Service de Reanimation Chirurgicale, Centre Hospitalier Universitaire Joseph RavoahangyAndrianavalona, Ampefiloha, 101 Antananarivo Madagascar., Harifetra Mamy Richard Randriamizao ,   Service de Reanimation Chirurgicale, Centre Hospitalier Universitaire Joseph RavoahangyAndrianavalona, Ampefiloha, 101 Antananarivo Madagascar., Andriambelo Tovohery Rajaonera ,   Faculte de Medecine dAntananarivo, BP 375, Antananarivo Madagascar.
Published: June 2023

Aim: The aim of the study is to assess the effect of oxytocin on the hemodynamic status of patients with variceal upper digestive hemorrhage becausethe main principle of the management of this pathology is hemodynamic optimization through vasoconstrictors (octreotide, somatostatin, ...), that are not available in Madagascar. Materials and Methods: A descriptive and monocentric, retrospective study was carried out in University Hospital J. R. Andrianavalona, for a period of 60 months (2010 to 2014).Patients with known variceal upper gastrointestinal bleeding were included. Correlations (ChiÂ² or exact Fishers test, XLStatÂ®10.0) between oxytocin use and hemodynamic parameters, therapeutics and mortality were performed. Results: A number of 175 patients aged 47.5 Â± 13.6 years, predominantly male (sex ratio = 2.4) were studied. The admission pattern was dominated by the combination of hematemesis and melena (52.6%). The use of oxytocin had an impact on the decrease of hemodynamic parameters (p <0.05). This molecule limited perfusion and blood transfusion (p <0.001). The use of oxytocin had no impact on patient survival and death (18.3%) (p> 0.05). Conclusion: Because of the lack of main vasoactive drugs, oxytocin could be an alternative to vasoactive treatment in Antananarivo (Madagascar), without specific impact on the morbidity and mortality of upper gastrointestinal varicose bleedings.
SIGMOID VOLVULUS IN PREGNANCY: CASE REPORT AND REVIEW OFLITERATURE
Authors:   Obstetricsandgynecologydepartment,MohammedVIUniversityHospitalCenter,FacultyofMedecineandPharmacy,Marrakech,Morocco., Lakraimi K. , Sali M. ,   Obstetricsandgynecologydepartment,MohammedVIUniversityHospitalCenter,FacultyofMedecineandPharmacy,Marrakech,Morocco., Asmouki H. ,   Obstetricsandgynecologydepartment,MohammedVIUniversityHospitalCenter,FacultyofMedecineandPharmacy,Marrakech,Morocco., Aboulfalah A. ,   Obstetricsandgynecologydepartment,MohammedVIUniversityHospitalCenter,FacultyofMedecineandPharmacy,Marrakech,Morocco., Fakhif B. ,   Obstetricsandgynecologydepartment,MohammedVIUniversityHospitalCenter,FacultyofMedecineandPharmacy,Marrakech,Morocco., Bassir A. ,   Obstetricsandgynecologydepartment,MohammedVIUniversityHospitalCenter,FacultyofMedecineandPharmacy,Marrakech,Morocco., Harou K. ,   Obstetricsandgynecologydepartment,MohammedVIUniversityHospitalCenter,FacultyofMedecineandPharmacy,Marrakech,Morocco., A Asoummani ,   Obstetricsandgynecologydepartment,MohammedVIUniversityHospitalCenter,FacultyofMedecineandPharmacy,Marrakech,Morocco.
Published: June 2023

An uncommon, non-obstetric source of stomach discomfort called sigmoid volvulus complicatingpregnancy necessitates immediate surgical surgery (decompression) to prevent intestinal ischemiaandperforation.Wedescribethecaseofa22yeaoldpregnantwomanwhowas39weeksalongandexperienced stomach discomfort followed by constipation and vomiting. A CT scan allowed apreoperative diagnosis of sigmoid volvulus. The large bowel distension and a typical whirl sign werefound close to a sigmoid colon transition point. The patient was led to the OR where a laparotomywas performed allowing decompression of the sigmoid and the extraction of the newborn. In ourreport, we discuss the operative method used in asigmoid volvulus and differential diagnosis fromothernon-obstetricabdominalemergenciesinpregnancy.
MATERNAL AND PERINATAL OUTCOME IN WOMAN WITH ANTEPARTUM ECLAMPSIA
Authors:   Junior Resident, Department of Obstetrics and Gynaecology, BMCRI, Bangalore., Aliya Fatima Syeda , Bharati G. ,   Junior Resident, Department of Obstetrics and Gynaecology, BMCRI, Bangalore., Saahiti Permi ,   Junior Resident, Department ofObstetricsandGynaecology, BMCRI, Bangalore., B. Huilgol Gopalkrishna ,   Professor, Department of Obstetrics and Gynaecology, BMCRI, Bangalore.
Published: June 2023

Introduction:The term eclampsia is derived from a Greek word, meaning like a flash of lightening1. Eclampsia is an obstetric enigma. However, the management of eclampsia still poses a fascinating challenge to the obstetrician, requiring the greatest skill, judgement and patience2.The aim of this study to study the maternal and fetal outcome in woman with eclampsia. Materials And Methods: Anobservational study conducted in patients with antepartum eclampsia in Department of Obstetrics and Gynaecology at Vanivilas hospital, Bangalore Medical College and Research Institute, Bangalore, satisfying inclusion and exclusion criteria were taken as cases.The study period was 18months (February 2021 to August 2022)All the findings were recorded in the proforma and analysed. Results: A total of 106 patients satisfying both inclusion and exclusion criteria were included in the present study. Out of which, 46 patients(43.40%) were primigravida and 60 (56.60%) were multigravida. 54 (50.94%) of them underwent vaginal delivery and 52 (49.06%) patients underwent caesarean delivery. Most common indication for LSCS was unfavorable cervix. Maternal complications occurred in 10 patients (9.43%) and maternal mortality was 5.66% (6 patients).NICU admission was seen in 57 babies (58.16%) and neonatal death occurred in 11 babies (11.22%). Conclusion: By analysing maternal and perinatal outcome measures in woman with eclampsia, measures can be taken to expedite delivery and hence improving the maternal and perinatal outcome.
EFFECTS OF TURMERIC (CURCUMA LONGA L.) RHIZOME EXTRACT ONLUNGHISTOLOGICAL STRUCTUREIN MICE(MUSMUSCULUSL) INDUCEDNICOTINE
Authors:   Lecturers of Biology Departement, the Faculty of Mathematics and Natural Sciences, University of Jember., Fajariyah Susantin , Tyas Utami Eva ,   Lecturers of Biology Departement, the Faculty of Mathematics and Natural Sciences, University of Jember., A Mahriani ,   Lecturers of Biology Departement, the Faculty of Mathematics and Natural Sciences, University of Jember., Effendi Erviana ,   Biology Undergraduate Student at the Faculty of Mathematics and Natural Sciences, University of Jember.
Published: June 2023

Nicotine is an alkaloid compound found in tobacco leaves. The use of nicotine in a long period can cause lung damage.The aim of this study was to determine the effect of giving turmeric extract (Curcuma longa L.) on lung histological structure in nicotine-induced mice. In this study, 25 male mice were divided into 5 groups. Group 1 was a negative control group without nicotine-induced and turmeric extract. Group 2 was a positive control group induced by nicotine without turmeric rhizome extract, groups 3, 4 and 5 were groups exposed to nicotine followed by giving turmeric extract at doses of 0,98, 19,6 dan 29,4 mg/kg BW. The dose of nicotine given was 2.5 mg/kg BW, given intraperitoneally for 28 days. Turmeric extract was given as gavage for 14 days. The results showed that nicotine exposure resulted in an increase in mucosal thickness of the bronchioles and alveolar septa of mice. The administration of turmeric rhizome extract resulted in a decrease in the thickness of the bronchial mucosa and alveolar septa. Giving turmeric extract at a dose of 29,4 mg/kg BW resulted in a decrease in the thickness of the bronchial mucosa and alveolar septa. The conclusion of this study is that the 29,4 mg/kg BW dose of turmeric extract is effective in repairing histological damage to lung tissue in mice.
TERATOGENESIS IN AYURVEDA: UNDERSTANDING THE CONCEPT AND ITS IMPLICATIONS- A REVIEW
Authors: a Manisha , Gaur M.B.
Published: June 2023

Ayurveda is a life science which achieves health through a holistic approach. Concept of Ayurveda is to restore balance between body, mind and spirit with prevention and personalized treatments. Concepts about physiology, pathology and treatments were ascribed during the period of Vedas. Ayurveda explains Sharira (body) which is made up of Indriya (sense), Satva (mind), Atma (soul) and Panchamahabhutas (five elements). The process of growth, differentiation and development of cell leads to formation of organ, system and as a whole â€“ body. The process of life starts from conception. This marks the beginning of a new human life. Conception is a complex biological process which depends upon variety of factors. A healthy birth refers to delivery of a newborn without any physical developmental and congenital abnormality. On the other hand when there is physical, cognitive, developmental abnormalities are called teratogenic defects and the process by which abnormal development of the embryo or fetus occurs, resulting in birth defects is teratogenesis. In this article we put some light on teratogenesis explained by Acharyas in Ayurveda and their principles. Ayurveda offers valuable guidance for maintaining a healthy pregnancy and promotes the healthy development of fetus.
PREVALENCE OF ANATOMICAL VARIATIONS OF CIRCLE OF WILLIS IN SOUTH INDIAN POPULATION SUCCUMBING TO ISOLATED TRAUMATIC BRAIN INJURY - A CADAVERIC STUDY
Authors: D. Vinoth , R. Venkatesh
Published: June 2023

Introduction: The Circle of Willis (COW) is a large arterial anastomotic ring present at the basal cistern of the brain, uniting the internal carotid and the vertebro-basilar system. Sir Thomas Willis was the first to describe the importance of the circle in maintaining collateral flow. It was observed that there is very little mixing of blood between the collateral branches of the circle. These collaterals may however open up during occlusive episodes of the proximal feeding vessels or in case of severe stress such as stroke and traumatic brain injury (TBI) in order to maintain metabolic activity in the brain. This phenomenon is affected to various degrees in the presence of anomalies. The prevalence of anomalies of COW in the general population is up to 75.72% was demonstrated in other studies. Materials and Methodology: This is a cross sectional observational study. 20 consecutive patients above 18 years of age succumbed to isolated TBI who were subjected to medico-legal autopsy in our hospital were included. The anomalies were classified as per the criteria laid down by StojanoviÂ´c et al. Results: 9 Normal variants (Type A) of COW (45%) was found. The most common type of anomaly was Type C which was noted in 4 cases (20%). Conclusion: Anatomical variations of COW has proven association in the areas of stroke, aneurysm, migraine, carotid endarterectomy and ageing brains. Further studies are needed to determine whether the anomalies of COW really contribute to the mortality in TBI.
CLINICOETIOLOGICAL PROFILE, MANAGEMENT AND OUTCOME OF NEONATAL SHOCK PRESENTING WITHIN FIRST 72 HOURS OF LIFE
Authors:   Post Graduate Resident, Department of Pediatrics, Government Medical College, Srinagar. MBBS Graduate., Bhan Swati , Pattu Arshee ,   Post Graduate Resident, Department of Pediatrics, Government Medical College, Srinagar. MBBS Graduate.
Published: June 2023

Objective: To study the ethology, presentation, response to treatment and outcome of neonatal shock which is one of the most common causes of morbidity and mortality in neonates while at the same time being amongst the less studied topics in pediatrics, with data from children and adult being extrapolated to the neonates. Study Design: This was a cross sectional observational study done in a government hospital of north India from 1 January 2023 to 30 April 2023.All the neonates aged 0 â€“ 72 hours who presented to the neonatal intensive care unit (NICU) of the pediatric department of the hospital as a case of shock were included in the study. Shock was defined as decreased perfusion, altered mental status, diminished or bounding pulses, cool extremities or decreased urine output. Results: Our study included 71 patients (54.9% males and 45.1% females) out of which 77.5 % participants presented within 24 hours of birth. 54.9% babies had normal weight and 47.9% were early term. Babies born via LSCS were more likely to develop and present earlier with shock. 43.7% cases were attributed to respiratory distress syndrome, 32.4% cases to perinatal asphyxia and 27.1% to sepsis. Sepsis and Meconium aspiration were more likely to present earlier. 25.4% required triple inotropic support and 7% had catecholamine refractory shock. Mortality was 18.3% with maximum mortality seen in patients on triple inotropic support, all of whom presented with shock at less than 24 hours of age.
CLINICAL PROFILE OF FUNCTIONAL CONSTIPATION IN CHILDREN
Authors:   Junior Resident., R. Aparna , S.A Varsha ,   Professor Department of Paediatrics, MVJMC &RH.
Published: June 2023

Introduction:Constipation causes physical, psychological morbidity and poor quality of life Data from developed countries shows that prevalence of childhood constipation in general population ranges from 0.7-29.6%. Various studies have showed pain of passing hard stools in infancy and early childhood is the principal contributing factor for acute childhood constipation, leading to constipation and soiling in adulthood. Because of lack of awareness regarding common occurrence of childhood constipation and its proper management, it is often underdiagnosed and sub optimally managed. Hence, this study was conducted to study the frequency of constipation and risk factors in children attending tertiary care hospital in rural Bangalore. Materials and methods: A total of 50 children attending pediatric OPD with constipation were surveyed at MVJ Medical College and Research Hospital, Bangalore. Children who fulfilled the ROME III criteria for constipation were analyzed for demographic profile, socio-economic status, psychosocial aspects and dietary habits affecting bowel pattern. Data was collected and recorded from the parents in pre-fixed proforma which also included Stool frequency and type of stool passed . Results: A total of 50 children fulfilled the ROME III criteria for functional constipation. The constipation in children had male preponderance and majority were aged 2-4 years. Majority of constipated children (62%, n=31) had retention behavior in the form of abnormal posturing. In children with constipation, the average number of stools passed in a week is 2.05. Conclusions: Constipation is an iceberg disorder. Skipping breakfast, early toilet practicing, low intake of vegetables and fruits , marital disharmony, sibling rivalry ,temper tantrums , school phobia , aversion to use school toilet were factors leading to constipation.
COMPARISON OF FERROUS SULPHATE WITH COLLOIDAL IRON IN THE TREATMENT OF IRON DEFICIENCY ANEMIA IN CHILDREN
Authors:   Resident of Department of Paediatrics at MVJMC and RH., B.A Prajwala , R. Premalatha ,   HOD and Professor of Department of Paediatrics at MVJMC and RH.
Published: June 2023

Background: Anemia is a major health problem throughout the world andchildren under 5 years of age are at highest risk. Nutritional deficiency isthe mostcommoncauseofanemiainchildrenunder2yearsofageduetohighrateofgrowthandincreaseddemandofiron,vitaminB12andfolicacid.According to WHO, 1 out of every 2 pre-school children are suffering from IDA indevelopingcountries. Different oral iron preparations are available totreatIDA.Hence, this study was done to compare the therapeutic efficacy andside effects offerroussulphatewithcolloidalironinthetreatmentofIDAinchildren. OBJECTIVES: 1. TocomparethetherapeuticefficacyofferroussulphatewithcolloidalironinthetreatmentofIDAinchildrenaged6monthsto18years. 2. Tocomparethesideeffectsbetweenthetwogroups. Methods: This randomizedcontrol study was conducted in MVJ medicalcollegeandresearchhospital,Hoskote,Bangalore.Eligiblechildrenwererandomized to 2 groups. Group A consisting of 75 children were given ferroussulphateinadoseof3mg/kg/dayofelementalirononcedailyfor4weeks.GroupBconsistingof75childrenweregivencolloidalironinadoseof3mg/kg/dayof elemental iron once daily for 4 weeks. Reticulocyte countbetween the twogroupswas checked at the end of one week and haemoglobinat the end of onemonth. Side effects and compliance of the two ironformulations were checked onfollowup. Results: The mean rise in the reticulocyte count at the end of 1 week is higherincolloidalironincomparisontoferroussulphategroup.Themeanriseinhaemoglobin at the end of one month is more in colloidal iron compared to ferroussulphate group, however the difference is not statistically significant. Compliancewith colloidal iron is better than ferrous sulphate group, as nausea is comparativelymorewithferroussulphategroupwhichattributedtodecreasedcompliancewhichisstatisticallysignificant. Conclusion: Colloidal iron and ferrous sulphate are found to be equallyefficacious in thetreatment of iron deficiency anemia. However, owing to its goodcompliance and lesser GI side effects, colloidal iron is found to bepreferable overferroussulphate. Hence, the study suggests the use of colloidal iron to treat IDA in children between 6 months to 18 years.
THE AETIOLOGY OF ADOLESCENT IDIOPATHIC SCOLIOSIS: IS SLEEP POSITION THE MISSING LINK? THE NIGHTTIME PERFECT STORM HYPOTHESIS
Authors:   Research conducted at: Grunstein Family Chiropractic Center 340 East Northfield Road, Suite 2E Livingston, New Jersey 07039, USA., B. Grunstein D.C Jarrett , B. Grivas MD PhD Theodoros ,   Former Head of the Department of Orthopaedics and Traumatology, Tzaneio General Hospital of Piraeus, Zanni and Afendouli 1, Piraeus, 18536, Greece.
Published: June 2023

A review of the literature on adolescent idiopathic scoliosis (AIS) reveals that the cause remains unknown. Further, scientific investigation by researchers around the globe has determined that neither the nervous or endocrine systems, nor the muscular, connective, or osseous tissues are the primary causative factors which lead to the development of spinal curvatures as seen in AIS. This report will serve to introduce a new hypothetical model that we have termed, The Nighttime Perfect Storm Hypothesis. The model serves to explain why peripubescent children who have a particular genetic predisposition may be at heightened risk of developing a curvature in their spine if their body is habitually positioned while asleep in what we refer to as the Provocative Sleep Position (PSP). The concept of spinal stabilization is explored with respect to a landmark theoretical model by Panjabi in 1992. In the case of AIS, the childs spinal stabilization has gone completely awry. Through the lens of our hypothesis, this loss of stabilization is due to four interdependent components that may conspire and lead to the perfect storm. These components include 1) a genetic predisposition, 2) sleeping in the Provocative Sleep Position, 3) while in the REM stage of sleep, 4) during the childs peripubescent growth spurt. Included is a complete biomechanical analysis of the childs spine while lying in either the Prone or Lateral PSP, and how this may lead to the development of a thoracic or lumbar curvature, respectively. Finally, we propose a path forward that will make clear the need for subsequent scientific investigation to determine whether or not the The Nighttime Perfect Storm Hypothesis is a viable theory.
COVID-19 AND MYASTHENIA: A CASE REPORT AND REVIEW OF MANAGEMENT STRATEGIES
Authors:   Anesthesia and Intensive Care Department,Ibn Tofail Hospital, University Hospital Mohammed VI of Marrakesh, Morocco., Rahmani Chadi ,   Faculty of Medicine and Pharmacy of Marrakesh, Cadi Ayyad University, Morocco., Badiy Amine ,   Anesthesia and Intensive Care Department,Ibn Tofail Hospital, University Hospital Mohammed VI of Marrakesh, Morocco.,   Faculty of Medicine and Pharmacy of Marrakesh, Cadi Ayyad University, Morocco., Meghraoui Yassine ,   Anesthesia and Intensive Care Department,Ibn Tofail Hospital, University Hospital Mohammed VI of Marrakesh, Morocco.,   Faculty of Medicine and Pharmacy of Marrakesh, Cadi Ayyad University, Morocco., Choukri Ahmanna Hussein ,   RadiologyDepartment, Ibn Tofail Hospital, University Hospital Mohammed VI of Marrakesh, Morocco.,   Faculty of Medicine and Pharmacy of Marrakesh, Cadi Ayyad University, Morocco., Elouardi Youssef ,   Anesthesia and Intensive Care Department,Ibn Tofail Hospital, University Hospital Mohammed VI of Marrakesh, Morocco.,   Faculty of Medicine and Pharmacy of Marrakesh, Cadi Ayyad University, Morocco., Khallouki Mohamed ,   Anesthesia and Intensive Care Department,Ibn Tofail Hospital, University Hospital Mohammed VI of Marrakesh, Morocco.,   Faculty of Medicine and Pharmacy of Marrakesh, Cadi Ayyad University, Morocco.
Published: June 2023

Background: The COVID-19 pandemic poses unique challenges in managing patients with pre-existing autoimmune disorders, such as myasthenia gravis. This article presents a case report of a myasthenic patient who contracted COVID-19, providing insights into the clinical presentation, diagnostic workup, treatment approaches, and disease course. Methods: A comprehensive review of the literature was conducted to examine the current understanding of the interaction between myasthenia gravis and COVID-19. The focus was on the challenges faced in managing these patients and the optimal therapeutic strategies. Results: The case report describes a 42-year-old male with confirmed myasthenia gravis who presented with sudden-onset respiratory distress and flu-like symptoms. The patients clinical course, including the utilization of immunomodulatory therapies and respiratory support, is discussed. The review of the literature highlights the increased risk of severe infection in myasthenic patients, the potential exacerbation of myasthenic symptoms, and the impact of immunosuppressive treatments on the course of COVID-19. Conclusion: The management of myasthenia gravis patients with COVID-19 requires a tailored approach that considers the delicate balance between controlling the viral infection and preserving neuromuscular function. Early recognition, prompt diagnosis, and the integration of multidisciplinary care are crucial for optimizing outcomes in this patient population. Further research is needed to enhance our understanding of the underlying mechanisms and refine management strategies for these complex cases.
SERUM MAGENSIUM LEVEL AND ELECTROCARDIOGRAPHIC CHANGES IN ACUTE ORGANOPHOSPHOROUSPOISONING
Authors:   Department Of General Medicine., T.D Sushmitha , M.M Basavaraju ,   Mysore Medical College and Research Institute, Mysore., L. Sandesh ,   Mysore Medical College and Research Institute, Mysore.
Published: June 2023

Introduction:Organophosphorous poisoning is one among the most common poisoning seen in India due to its easy availability and accessibility.It has varied mechanism by which it damages the human system.cardiovascular toxicity is one among the many.Serum Magnesium level also plays a role in prognosis of OP poisoning .In this Study we have tried to study varied Ecg manifestations and magnesium levels in op poisoning cases attending K R Hospital,mysore . Materials And Methods:This was a cross sectional study, and data was collected from the routine investigations of the cases and secondary sources from published journals . The data was analysed by SPSS software version 20 and chi square test was applied for qualitative variables. Results:In 50 OP poisoning cases studied with (male- 43 ,Female- 7)with mean age of 43 among males and 34 among females,the commonest poison consumed was chlorpyrifos(24).ECG Findings showed Sinus Tachycardia (38%)as the most common manifestation in my study with Normal sinus Rhythm (20%) Second most common finding,QT prolongation(18%),St-t changes(12%),Premature ventricular complex(6%),Sinus bradycardia(2%),Ventricular tachycardia(4%).Hypokalemia was seen in 17 patients with mean of 3.45 among Female and 3.70 among Males.Mean Serum magnesium was 1.73 among males and 1.64 among Females.MeanPseudocholinesterase level observed was 1885. Conclusion: Subjects with Hypokalemiaand sinus Tachycardia and Qtprolonation had a high mortality and morbidity as compared to other subjects.
REFLECTION ON THE LATEST PISA RESULTS OF INDONESIA
Authors:   Department of Mathematics Education, Universitas Sultan AgengTirtayasa, Indonesia., Nandang Mustafa Ade
Published: June 2023

In order to improve the quality of education, the Indonesian education system faces tremendous obstacles. Poor scores in reading, mathematics, and science on the most recent PISA indicate problems with teaching quality, infrastructure, facilities, curriculum, and assessment processes. Indonesia has a traditional approach to education that emphasizes rote learning and memorization, and the language of instruction is mainly Indonesian. To increase the quality of education, the government must invest more in teacher education programs, infrastructure and facilities, and curriculum and assessment system change. By providing better training and resources for teachers, modernizing school buildings and equipment, and incorporating new subjects and skills into the curriculum, Indonesia can give students more options and prepare them for the challenges of the global economy.
EPIDEMIOLOGY AND RISK FACTORS OF SICK-BUILDING SYNDROMEAMONG HEALTH CARE WORKERS AT PRIMARY HEALTH CARE CENTER IN AL-AHSA,SAUDI ARABIA
Authors:   Ministry of Health, Eastern Province, Eastern Health Cluster in Saudi Arabia. Senior Resident in the Joint Program of Preventive Medicine, Al-Ahsa., Anwar Albinissa Mohammed , Sattar Khan Abdul ,   Head, Family & Community Medicine Department King Faisal University, Al-Ahsa in Saudi Arabia.
Published: June 2023

Objective: This study aimed to investigate the Epidemiology and risk factors of Sick-building Syndrome among health care workers at primary health care center in Al- Ahsa, Saudi Arabia Methods: cross-sectional study was conducted to evaluate different parameters for sick building syndrome and intrinsic, extrinsic factors involved in it. SBS symptoms and perceptions of various environmental aspects from a sample of 281 participants. The participants were asked to rate their symptoms and evaluate the environmental conditions based on specific factors such as air quality, temperature comfort level, air movement, light, vibration, overall comfort, and noise. Results: 18.1%of individuals reported experiencing symptoms associated with SBS. The results revealed a significant association between air quality and the presence of SBS symptoms (p = 0.001), with SBS symptoms being more prevalent in perceived stuffy air conditions. However, no significant associations were found between SBS symptoms and other environmental aspects, including temperature comfort level, air movement, light, vibration, and overall comfort. Notably, noise in winter showed a statistically significant association with SBS symptoms (p = 0.021), with 23.5% of participants reporting dissatisfaction. Conclusion: The findings suggest that air quality, particularly the perception of stuffy air, is significantly associated with the occurrence of SBS symptoms. These results align with previous research highlighting the importance of proper ventilation and reducing pollutant sources to mitigate SBS symptoms. With prevalence of SBS OF 18.1% among participants. Additionally, the study emphasizes the impact of noise pollution on SBS symptoms during the winter season. Further research is needed to explore the complex interactions between individual susceptibility, specific pollutant exposures, and building characteristics in the development of SBS symptoms.
En el tiempo de la caricia
Authors: Viola Federico Ignacio , Rodríguez Francisco Javier , Pignalitti David Antonio
Published: June 2023

El presente estudio propone un enfoque crítico de la cuestión del mal y del sufrimiento humano. En el marco del pensamiento ético de Levinas y desde una nueva perspectiva respecto de la concepción actual del lenguaje y del cuerpo, pretendemos cuestionar todas las formas de racionalismo y comprensión metafísica acerca del dolor y del sufrimiento humano. El propósito del presente estudio consiste en delinear una nueva forma de comportamiento en torno a la cuestión del mal y la debilidad humana, buscando alternativas conceptuales para esclarecer este complejo problema ético.
Editorial
Authors: Hewitt Ramírez Nohelia
Published: June 2023

Editorial
The Code of Professional Ethics and Good Governance on the Quality of Company Financial Statements
Authors: Pangaribuan David , Nuryati Tutty , Manurung Bennardo
Published: June 2023

The problems that will be examined in this study relate to empirical hypothesis testing how the influence of understanding professional ethics and the application of good governance principles on the quality of the company's financial statements presentation. The research sample is accountants who work in public accounting firms in Bekasi, West Java and East Jakarta with a total sample of 100 respondents. The sampling method used purposive sampling in accordance with the expected objectives of this study. The research approach is quantitative research with the type of correlational research. The results of the study reveal that (1) Understanding of Professional Ethics has a positive effect on the quality of the presentation of the company's financial statements. This means that the better the understanding of accountants about their professional ethics, the better their awareness and commitment to carrying out their professional ethics specifically in their duties and responsibilities in the preparation of quality financial reports. (2) The application of Good Governance has a positive effect on the quality of the presentation of the company's financial statements. This means that a good understanding and commitment to the application of the principles of transparency, accountability, participation and responsiveness will motivate the commitment of accountants in the presentation and preparation of quality corporate financial reports.
The Influence of The Work Environment, Work Discipline and Work Motivation on The Work Productivity
Authors: Adelliani Fauziah Putri , Fatimah Nuzulul , Sari Anita Kartika , Suwangsih Iwang , Zargar Nasir Ahmad
Published: June 2023

This study aims to determine the Effect of Work Environment, Work Discipline, and Work Motivation on Post-New Normal Village Apparatus Work   Productivity. The method used in this study is a non-probability sampling method with a saturated sampling technique. The sample in this study was all 50 village apparatus Village Government. Data collection techniques are observation, questionnaire, and literature study. The data analysis method used in this study is Multiple Linear Regression. The results of this study show that the variables are Work Environment,  Work Discipline, and Work Motivation has a partial significant effect on the Work Productivity of Village Apparatus after the new normal. The variables of Work Environment, Work Discipline, and Work Motivation have a significant simultaneous effect on the Work Productivity of Village Apparatus after the new normal in Village Government.
Pengaruh Kualitas Produk, Harga, dan Citra Merek pada Keputusan Pembelian Mobil
Authors: Alawiah Widiastuti , Utama Andyan Pradipta
Published: June 2023

This study ains to analyze the influence of product quality, price and brand image on purchasing decisions for Toyota Calya Car at DKI Jakarta. The approach used in this research is survey research because it takes a sample from one population and take a sample size of 220 respondens with purposive  sampling. The Methods of data collection using survey method, with the research instrument is a questionnaire. The data analysis method using Partial Least Square. This study proves that product quality has a positif and significant impact on purchasing decisions, the price has a positif and significant impact on purchasing decisions and brand image has a postif and significant impact on purchasing decisions.
ÍNDICES DE SELECCIÓN ENTRE CARACTERES AGRONÓMICOS Y QUÍMICOS EN HÍBRIDOS DE MAÍZ MORADO (Zea mays L.) EN EL SUR DE SONORA, MÉXICO
Authors: Rodríguez-Pérez Gilberto , García-Ramírez Alejandro , Reynaga-Franco Felipe de Jesús , Mendívil-Mendoza Jaime Edzael , Ochoa Meza Alba Rocío
Published: June 2023

En Mexico, el maíz es considerado el cultivo más importante, el 88% es sembrado de maíz blanco, 11% amarillo y 1% de color, los maíces azules o morados son ricos por sus propiedades nutrimentales al contener antocianinas caracterizándoles como especiales para el consumo humano. El objetivo de esta investigación fue estimar índices de selección utilizando caracteres agronómicos y químicos en híbridos de maíz morado en el sur de Sonora, se evaluaron 19 híbridos y un maíz criollo en campo y laboratorio, una vez cosechado el experimento, la semilla se evaluó en el laboratorio de alimentos del TecNM-Valle del Yaqui, las variables agronómicas fueron días a floración femenina (DFF), rendimiento de grano (RG), peso de mil granos (PMG), peso hectolitrico (PH), índice de flotación (IF), granos por hilera (GH), hileras por mazorca (HM), longitud de mazorca (LM), las químicas: grasa, cenizas, fibra, proteínas, carbohidratos y antocianinas. Los resultados mostraron diferencias estadísticas en todas las variables, los índices de selección permitieron identificar a los híbridos 19, 14, 7, 16, 18, 15, 9 y 10 por presentar valores mínimos en todas las variables simultaneas estudiadas, tuvieron los mejores rendimientos, fueron de ciclo más tardío, presentaron mayor PMG, fueron de una textura suave, especiales para la elaboración de tortillas, también obtuvieron los promedios superiores en grasa, fibra, proteínas, antocianinas y carbohidratos, los cuales son favorables por sus propiedades nutrimentales, las cuales tendrán efectos benéficos y antioxidantes que pueden beneficiar a la salud humana en diferentes productos derivados de maíces pigmentados, estos mismos híbridos se asociaron más GH, RG, IF, PH, grasa, fibra, proteína y antocianinas.
Effectiveness and Safety of Lacosamide, A Third-generation Anti-seizure Medication, for Poststroke Seizure and Epilepsy: A Literature Review
Authors: Chen Yu-Shiue , Lai Ming-Chi , Chen Tsang-Shan , Tseng Yung-Hsin , Li Ya Jhen , Huang Chin-Wei
Published: June 2023

Advances in stroke treatment have resulted in a dramatic reduction in stroke mortality. Nevertheless, poststroke seizures and epilepsy are issues of clinical importance affecting survivors. Additionally, stroke is the most common cause of epilepsy in older adults. Although numerous antiseizure medications exist, studies are needed to provide robust evidence of the efficacy and tolerability of these medicines for treating poststroke seizures and epilepsy. Crucially, the newer generations of antiseizure medications require testing. Lacosamide, a third-generation antiseizure medication approved for treating localization-related epilepsy, has a novel mechanism of selectively enhancing the slow inactivation of sodium channels. This literature review evaluated whether lacosamide is effective and safe for the treatment of poststroke seizures and epilepsy. This review critically analyzed studies published in major academic databases (Pubmed, Embase, and Cochrane Library) from inception through June 2022 regarding the interaction of lacosamide with poststroke seizures and epilepsy. We included clinical prospective, retrospective, and case studies on patients with poststroke seizure and epilepsy, lacosamide as a treatment for seizures, neuroprotection in animal models of seizures, and the safety of lacosamide when coadministering anticoagulants. Clinical studies revealed lacosamide to be an effective antiseizure medication with high efficacy and tolerability in patients with poststroke seizures and epilepsy. In animal models, lacosamide proved effective at seizure reduction and neuroprotection. Pharmacokinetic studies demonstrated the safety of lacosamide when coadministering conventional and new anticoagulants. The literature suggests that Lacosamide is a promising candidate antiseizure medication for patients with poststroke seizures and epilepsy.