bluuebunny/crossref_metadata_2025 huggingface dataset:
Creation of a Biobank of the Sperm of the Honey Bee Drones of Different Subspecies of Apis mellifera L. Using a Honey Extender
Authors: D. And Kaskinova Milyausha , Gulov Alexey , Berezin Andrey , Larkina Elena , Saltykova Elena
Published: November 2023

The cryopreservation of gametes and embryos is an important element of biodiversity conservation. One species in need of conservation is the honey bee Apis mellifera L. Changing environmental factors, especially the anthropogenic factor, have led to a reduction in the numbers of this insect species. In this study, we provide an example of the creation of a biobank of honey bee drone sperm. For sperm cryopreservation, drones of the most common subspecies of honey bees common in Russia were selected. These were the dark forest bee, Apis mellifera mellifera from the Republic of Bashkortostan, with three subspecies (A. m. carnica, A. m. carpatica, and A. m. caucasica) from the southern regions of Russia, as well as two breeding stocks, the Far Eastern bee and Prioksky bee. For subspecies identification, morphometric and genetic methods were used. The subspecies of the studied samples were confirmed by the analysis of the tRNAleu-COII locus of mitochondrial DNA and nine microsatellite markers of nuclear DNA. It was shown that bees of the Prioksky breeding stock belong to the subspecies A. m. caucasica based on phylogenetic analysis, and the Far Eastern breeding stock is a stable hybrid, descending on the maternal line from the evolutionary lineage C or O. The results of the morphometric analysis are consistent with the results of the genetic analysis. For the cryopreservation of sperm, we used a honey diluent. As a result, the viability of frozen–thawed sperm decreased by 20.3% compared to fresh sperm, and overall motility decreased by 25-fold. The measurement of the sperm concentration in the spermatheca of artificially inseminated queens showed that it varied from 0.22 to 4.4 million/μL. Therefore, the use of honey in sperm cryopreservation has great potential.
Brucellosis Seropositivity Using Three Serological Tests and Associated Risk Factors in Abattoir Workers in Gauteng Province, South Africa
Authors: Kolo Francis B. , Adesiyun Abiodun A. , Fasina Folorunso O. , Harris Bernice N. , Rossouw Jennifer , Byaruhanga Charles , Geyer Hermaus De Wet , Blumberg Lucille , Frean John , VanHeerden Henriette
Published: November 2023

Abattoir workers are liable to zoonotic infections from animals and animal products, pri-marily to diseases with asymptomatic and chronic clinical manifestations in animals such as brucellosis. No published reports exist on the seroprevalence of brucellosis in abattoir workers in South Africa. Therefore, this cross-sectional study was conducted to estimate the occurrence and risk factors for Brucella exposure in abattoir workers in Gauteng Province. A total of 103 abattoir workers and managers from six abattoirs, where brucellosis-positive slaughtered cattle and sheep were previously detected, were interviewed, and tested with serological assays using the Rose Bengal test (RBT), BrucellaCapt, and IgG-ELISA. A pre-tested questionnaire was administered to consenting respondents to obtain infor-mation on risk factors for brucellosis. Of the 103 respondents tested, the distribution of fe-male and male workers was 16 (15.5%) and 87 (84.5%), respectively. The seroprevalence for exposure to brucellosis was 21/103 (20.4%, 95%CI: 13.1-29.5) using a combination of RBT, BrucellaCapt, or IgG-ELISA. For test-specific results, seroprevalences by RBT, BrucellaCapt, and IgG-ELISA were 13/103 (12.6%, 95%CI: 6.9-20.6), 9/103 (8.74%, 95%CI: 4.1-15.9) and 18/103 (17.5%, 95%CI: 10.7-26.2), respectively. Low-throughput abattoirs were identified as associated risk as 29.3% of workers were seropositive compared to 12.7% of workers in high-throughput abattoirs, which highlights that direct contact at abattoirs poses higher risk to workers than indirect and direct contact outside abattoirs. This study confirmed the occurrence of Brucella spp. antibodies among abattoir workers in South Africa, possibly due to occupational exposure to Brucella spp. and highlight the occupational hazard to workers. Furthermore, findings underscore that abattoir facilities can serve as points for active and passive surveillance for indicators of diseases of public health importance. We recommend periodic implementation of brucellosis testing of abattoir workers country-wide to establish baseline data for informing appropriate preventive practices and reduce the potential burden of infection rate among these high-risk workers.
Revisiting the Asian Buffalo Leech (Hirudinaria manillensis) Genome: Focus on Antithrombotic Genes and Their Corresponding Proteins
Authors: Liu Zichao , Zhao Fang , Huang Zuhao , Hu Qingmei , Meng Renyuan , Lin Yiquan , Qi Jianxia , Lin Gonghua
Published: November 2023

Leeches are well-known annelids due to their obligate blood-feeding habits. Some leech species secrete various biologically active substances which have important medical and pharmaceutical value in antithrombotic treatments. In this study, we provide a high quality genome of the Asian buffalo leech (Hirudinaria manillensis), based on which we performed a systematic identification of potential antithrombotic genes and their corresponding proteins. Combining automatic and manual prediction, we identified 21 antithrombotic gene families including fourteen coagulation inhibitors, three platelet aggregation inhibitors, three fibrinolysis enhancers, and one tissue penetration enhancer. A total of 72 antithrombotic genes, including two pseudogenes, were identified and most of their corresponding proteins forming three or more disulfide bonds. Three protein families (LDTI, antistasin, and granulin) have internal tandem repeats containing 6, 10, and 12 conserved cysteines, respectively. We also measured the anticoagulant activities of the five identified hirudins (hirudin_Hman1 ~ hirudin_Hman5). The results showed that three (hirudin_Hman1, hirudin_Hman2, and hirudin_Hman5), but not the remaining two, exhibited anticoagulant activities. Our study provides the most comprehensive collection of antithrombotic biomacromolecules from a leech to date. These results will greatly facilitate the research and application of leech derivatives for medical and pharmaceutical purposes of thrombosis.
Impacts and Prevalence of Sarcopenia in Patients with MASLD: A Cross-Sectional Study
Authors: Berleze Kally Janaina , Ferreira Luis Fernando , D'Ávila André Ferreira , Buss Caroline , Tovo Cristiane Valle , Telles da Rosa Luis Henrique
Published: November 2023

Introduction: Sarcopenia, muscle loss, often coexists with MASLD, a common liver disorder, which is more prevalent in those with sarcopenia. Sarcopenia also increases the risk of liver conditions like steatosis and fibrosis. Studies on sarcopenia in MASLD are common in developed countries, but fewer follow the EWGSOP2 guidelines in Brazil. Aim: to assess sarcopenia prevalence in MASLD patients. Methods: Cross-sectional study conducted at the Gastroen-terology/Hepatology Service of ISCMPA with patients diagnosed with MASLD. The EWGSOP2 criteria were used to evaluate sarcopenia. Categorical data presented as absolute and relative frequency; parametric continuous data ex-pressed as mean±standard deviation; non-parametric continuous data as me-dian and IQR. Gender differences in were analyzed using Fisher's Exact Test or Chi-squared tests, and for continuous variables, T Student tests (parametric) and Mann-Whitney U tests for independent samples (non-parametric). The significance level was set at 5% (p<0.05). Results: The study involved 103 MASLD patients with an average age of 60.39 years, comprising 48 (46.60%) adults and 55 (53.40%) older individuals. Concerning sarcopenia diagnosis, four individuals exhibited decreased muscle strength; two had reduced MME (sarcopenia); and one showed decreased walking speed (severe sarcopenia). Among the participants, 63 (60.6%) were physically active. 35 (62.5%) had mild to moderate steatosis, while 21 (37.5%) had severe steatosis. In terms of EHNA, 13 subjects (24.08%) had moderate to severe EHNA. Regarding fibrosis classi-fication, 68 (72.34%) individuals had undetermined or high probability based on the NAFLD score, with higher prevalence in males (n=23; 88.5%). Fibrosis assessment via liver biopsy revealed 27 (28.72%) in F1 and F2 and 15 (16.96%) in F3 and F4. Stratification of fibrosis into F3 and F4 was more com-mon among men (n=9; 47.4%). Conclusion: Most of the population was physi-cally active. The parameters indicating sarcopenia exceeded the thresholds recommended by EWGSOP2. The prevalence of sarcopenia was low in individuals with MASLD.
Effect of Rehydration on the Physical-Mechanical Properties of CO2-Cured Magnesium-Based Fiber Cement Boards
Authors: Azevedo Adriano , Molano Juan Camilo , Parente Igor , Freitas Taís , Azevedo Aires Fernando , Faria Paulina , Savastano Junior Holmer
Published: November 2023

During carbonation process, the presence of water is an important parameter to accelerate this phenomenon. The carbon dioxide (CO2) has been used as curing process production of fiber cement boards keeping the dimensional stability of cellulose fibers in cementitious matrix and promoting the CO2 capture of environment. In addition, magnesium oxysulfate (MOS) cement has been used as another alternative binder to reduce the amount of CO2 in the nature. The aim of this scientific paper is analysis the effect of rehydration method on the physical-mechanical properties of CO2-cured magnesium-based fiber cement boards. These boards were produced by Hatschek process simulation. The physical-mechanical performance and microstructural characteristics of MOS boards before and after carbonation were investigated by: water absorption (WA), apparent porosity (AP), and bulk density (BD); four-point bending test; X-ray diffraction (XRD); thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). According to the results, it was possible observe which the accelerated carbonation process resulted in improvements in the mechanical properties of the boards. The boards carbonated after 48 hours showed higher Modulus of Rupture values. The rehydration process of the composites before carbonation led to enhancements in the boards pre-cured for 48 and 72 hours, demonstrating that carbonation occurred more effectively after the supply of water through rehydration. The improvements in mechanical properties were associated with the formation of hydration products, which preferentially formed in the pores and voids of the fiber-cement. The presence of these carbonation products altered the physical properties of the materials, increasing the density of the boards and reducing the void volume. The decomposition of the formed carbonates was confirmed by thermogravimetric analysis, which indicated that the rehydration process favored the carbonation of the materials
A Dual Mediation Model for Evaluating the Impact of Organizational Change on Employee Innovation Performance
Authors: Shaturaev Jakhongir , Khakimova Mukhabbat , Fayzullaeva Nilufar , Kholmuratov Salim
Published: November 2023

Affected by the COVID-19 and the international development pattern, the international environment has undergone profound changes, and enterprises, as the main body of activities rushing in the front line of production and operation and the main battlefield of market competition, are facing various risk challenges in the domestic and international markets. For theoretical research, the impact of organizational change on employee innovation performance has become a key issue in organizational behavior and human resource management research. However, the influence mechanism of organizational change on employee innovation performance is still unclear. In this study, we examine whether, how, and when organizational change increases employee innovation performance in accordance with job demands-resource theory, as well as the effect of work pressure and work engagement on employee innovation performance. Data from 289 employees at three time points are examined. The results show that: (1) Organizational change negatively affects employee innovation performance through work pressure, i.e., work pressure mediates the impact of organizational change on employee innovation performance. (2) Organizational change positively affects employee innovation performance through work engagement, i.e., work engagement mediates the impact of organizational change on employee innovation performance. (3) Organizational identity plays a moderating role between organizational change and work pressure and work engagement, respectively, and there is a moderating effect in the process of mediation of work pressure and work engagement. The findings of this study provide important insights into how and when organizational change influences employee innovation performance.
Mark Burgin’s Legacy: The General Theory of Information, The Digital Genome, and the Future of Machine Intelligence
Authors: Mikkilineni Rao
Published: November 2023

With 500+ papers and 20+ books spanning many scientific disciplines, Mark Burgin has left an indelible mark and legacy for future explorers of human thought and information technology professionals. In this paper, I discuss his contribution to the evolution of machine intelligence using his general theory of information (GTI) based on my discussions with him and various papers I co-authored during the past eight years. His construction of a new class of digital automata to overcome the barrier posed by the Church-Turing Thesis, and his contribution to Super-Symbolic Computing with Knowledge Structures, Cognizing Oracles, and Structural Machines are leading to practical applications changing the future landscape of information systems. GTI provides a model for the operational knowledge of biological systems to build, operate, and manage life processes using 30+ trillion cells capable of replication and metabolism. The schema, and associated operations derived from GTI are also used to model a digital genome specifying the operational knowledge of algorithms executing the software life processes with specific purposes using replication and metabolism. The result is a digital software system with a super-symbolic computing structure exhibiting autopoietic and cognitive behaviors that biological systems also exhibit. We discuss here one of these applications.
Play Behavior as a Positive Welfare Indicator for Farmed Spotted Paca (Cuniculus paca)
Authors: Lima Allison Ferreira de , Lima Stella Guedes Calazans , Nogueira-Filho Sérgio L G , Held Suzanne D. E. , Mendl Michael , Nogueira Selene Siqueira da Cunha
Published: November 2023

We aimed to assess whether play behavior can be used as a welfare indicator for farmed spotted pacas (Cuniculus paca) by examining its association with other positive welfare markers including affiliative behavior and low-amplitude vocalizations. We submitted six groups of spotted pacas (one male/two females per group) (N=18) to an ABA experimental design (A1/A2: without ball; B: with three boomer balls). Play behavior occurred only during phase B (mean=35.5s, SE=6.4). Spotted pacas spent more time in affiliative and exploratory behaviors, while they spent less time engaging in agonistic interactions during phase B than in both control phases (A1 and A2) (P<0.05). Moreover, spotted pacas emitted more low-amplitude bark vocalizations during phase B than during either control phase (P<0.05), which have previously been shown to indicate a positive affective state and low arousal level. Because the expression of play was associated with a decrease in aggression, an increase in affiliative behavior, and an increase in low-amplitude barking, indicating thus a positive state, we suggest that play behavior can be used as a non-invasive indicator of positive welfare in this species.
Multi-Sensor Satellite to Assess Sea Level Rise and Land Subsidence Impact on the Flood Crisis on the East Coast of North Sumatra and Medan City, Indonesia
Authors: Lumban-Gaol Jonson , Sumantyo Josaphat Tetuko Sri , Tambunan Efendy , Situmorang David , Antara I Made Oka Guna , Arhatin Risti Endriani , Osawa Takahiro , Sinurat Maya Eria , Suhita Ni Putu Asri Ratna
Published: November 2023

Flood disasters have become an annual occurrence along the East Coast of North Sumatra (ECNS) and Medan City. Numerous studies have examined the causal factors flood disasters in this area, such as changes in land use, drainage issues, and population growth, but the intensity of flood disasters continues to rise. In this research, we focused on evaluating the unexplored factors of land subsidence and rising sea levels in this region. Our investigation uses multi-sensor satellite data and field surveys to conduct an assessment of the rate of land subsidence and sea level rise and assess their implications on flood disasters. This study highlights the potential of multi-sensor satellite data as a primary resource for assessing flood disasters in coastal areas and densely populated large cities. Furthermore, we propose a solution to reduce the negative impact of flood disasters by by engaging local communities and environmental enthusiasts in mangrove reforestation along the coastline.
An Approach to Implementing High-Performance Computing for Problem Solving in Workflow-based Energy Infrastructure Resilience Studies
Authors: Feoktistov Alexander , Edelev Alexei , Tchernykh Andrei , Gorsky Sergey , Basharina Olga , Fereferov Evgeniy
Published: November 2023

Implementing High-Performance Computing to solve In-Memory Data Grid (IMDG)-based energy infrastructure resilience research problems in a heterogeneous environment presents a challenge to workflow management systems. Large-scale energy infrastructure needs multi-variant planning and tools to allocate and dispatch resources in IMDG taking into account the subject domain specificity, resource characteristics, and constraints and quotas for resource use. To that end, we propose a workflow management system using our Orlando Tools framework. To scale computing resources, we provide their integration and use corresponding software to determine key application parameters that can significantly impact the processed data size and the required number of allocated resources. We automated the IMDG cluster launch for the workflow executions. To demonstrate the advantage of our solution, we apply it to evaluate the resilience of the existing energy infrastructure model. Compared to similar approaches, our approach explores large infrastructures by modeling many simultaneously failed elements of different types up to the number of network elements. In terms of problem-solving efficiency and resource use, we achieve near-linear speedup with increasing the number of nodes of each resource.
Does the Prevalence of Subclinical Coronary Atherosclerosis Increase in Primary Hyperparathyroidism; Coronary Flow Reserve and Plasma Aterogenic Index in Patients with Primary Hyperparathyroidism
Authors: Cetinkaya Zeki , Kelesoğlu Saban , Gokay Ferhat , Yilmaz Yucel
Published: November 2023

Introduction: The coronary flow reserve (CFR) is a sign of early-stage coronary artery disease (CAD). Plasma atherogenic index (PAI) is related to atherosclerosis and cardiovascular mortality. Therefore, our aim was to determine CFR and PAI in patients with primary hyperparathyroidism (PHPT) and investigate whether PAI can be used in the detection of early-stage CAD.
Material and Methods: The sample was comprised of 44 patients with PTHT and 33 healthy volunteers. We defined CFR as the ratio of the hyperemic diastolic peak velocity to the baseline diastolic peak velocity. PAI values were calculated with the formula of log 10 triglyceride (TRG) / high-density lipoprotein (HDL).
Result: The comparison of the groups for PAI and CFR demonstrated that PAI levels were significantly higher while CFR levels were significantly lower in the PTHT patients (p<0.01, p=0.01, respectively). The correlation analysis revealed that CFR was negatively correlated with PAI and TRG (PAI- p<0.0001 r=-0.537).The multivariate logistic regression analysis showed that only a high PAI level (OR: 151.6, 95% confidence interval (CI): 4.1-5480, p=0.006) was an independent predictor of reduction in CFR in PHPT patients.
Conclusion: Overall, we found an independent correlation between PAI and CFR values. Hence, PAI may be useful in identifying PHPT patients facing a high risk of adverse cardiovascular events and may also allow early diagnosis of subclinical atherosclerosis.
In Search of the Optimal Measurement Parameters for Determining the Degree of Modification of Thermally Modified Wood by Thermogravimetry
Authors: Cerc Korošec Romana , Žener Boštjan , Čelan Korošin Nataša , Humar Miha , Kržišnik Davor , Rep Gregor , Lavrenčič Štangar Urška
Published: November 2023

When wood is thermally modified, several chemical reactions take place that change the chemical and physical properties of the wood. These changes correlate with the degree of modification, which is mostly a function of temperature and duration of modification, and consequently with a mass loss during this process. There is a lack of standardized quality control to verify the degree of heat treatment of wood and thus its quality. One of the possible methods to check the degree of thermal modification of a particular type of wood is thermogravimetry (TG). It is based on the assumption that processes that did not take place during thermal modification continue when the TG experiment is carried out. In this method, calibration curves have to be established based on TG measurements of standard samples that have been thermally modified at different temperatures and whose mass loss during modification is known. The calibration curves show the mass loss during the TG measurement as a function of the mass loss during the previous thermal modification. The course of thermal decomposition during the TG measurements is influenced by many parameters, such as the mass of the sample, the heating rate, the atmosphere in which the measurement takes place, and the shape of the crucible in which the sample is placed. In this paper, the influence of these parameters on the calibration curves was investigated. We have focused on oak wood. The best parameters result in a calibration curve with the largest correlation coefficient R2 and the highest slope of the line k. On this basis, we can determine the mass loss during thermal modification of unknown samples of the same wood species under the same measurement conditions.
Cellular Processes Caused by Human Herpesviruses Infection
Authors: Zhao Zhengdong , Liu Xiaozhou , Zong Yanjun , Shi Xinyu , Sun Yu
Published: November 2023

Herpesvirus is a prevalent pathogen that primarily infects human epithelial cells and has the ability to reside in neurons. In the field of otolaryngology, herpesvirus infection primarily leads to hearing loss and vestibular neuritis, and is considered the primary hypothesis regarding the pathogenesis of vestibular neuritis. Individuals afflicted with vestibular neuritis experience diz-ziness, which significantly impacts their daily lives. The impact of herpes virus infection on host cell processes and the targeted clearance of infected host cells by immune cells are likely the primary pathogenic mechanisms underlying vestibular neuritis. In this review, we provide a summary of the effects of herpes virus on cellular processes in both host cells and immune cells, with a focus on HSV-1 and HCMV as illustrative examples.
Network Reconfiguration for Loss Reduction using Tabu
Search and a Voltage Drop
Authors: Ñaupari Huatuco Dionicio Zocimo , Filho Luiz , Pucuhuayla Franklin Simeon , Rodriguez Yuri Percy M.
Published: November 2023

This work presents a new algorithm to resolve the problem of distribution network reconfiguration using the Tabu Search metaheuristic and voltage drop. The proposed method presents a different way to obtain the initial solution using the voltage drop, as well as a new way to generate a neighborhood of candidate solutions, based on randomness and the voltage drop, to perform a smooth and steady descent execution of the algorithm. The proposed algorithm has the main objective to reduce the active power losses in distribution networks, but it also achieves an refinement in the voltage profile. The proposed method was tested in two distribution systems, the 33-Bus and 94-Bus systems, commonly found and tested in the literature. The results of the tests show that the proposed method presents a low computational cost, achieves good solutions, and is better than the other methods found in the literature.
Characterization of Nanoprecipitated PET Nanoplastics by 1H NMR and Impact of Residual Ionic Surfactant on Viability of Human Primary Mononuclear Cells and Hemolysis of Erythrocytes
Authors: Djapovic Milica , Apostolovic Danijela , Postic Vojislava , Lujic Tamara , Jovanovic Vesna , Stanic-Vucinic Dragana , Van Hage Marianne , Maslak Veselin , Cirkovic Velickovic Tanja
Published: November 2023

Manufactured nanoplastic particles (NPs) are indispensable for in vitro and in vivo testing and health risk assessment of this emerging environmental contaminant. High surface area and inherent hydrophobicity of plastic material, makes production of NPs devoid of any contaminants very challenging. In this study we produced nanoprecipitated polyethylene terephthalate (PET) NPs (300 nm hydrodynamic diameter) and characterized presence of ionic surfactant sodium dodecyl sulfate (SDS) by 1H NMR. Relative ratio of NP/surfactant was monitored on the basis of chemical shifts characteristic for PET and SDS. For a wide range of surfactant/NP ratio (1:17 to 1:1.2), measured zeta potential changed from -42.10 to -34.93 mV, but no clear differences were observed in cellular assays performed in protein-rich media on primary human cells. The remaining impurities contributed to the outcome of biological assays applied in protein-free buffers, such as human red blood cells hemolysis. As size, shape, zeta potential and contaminants of NPs may all be relevant parameters for biological effects of NPs, relative quantification of impurities exemplified in our work by application of 1H NMR for PET NPs and ionic surfactant SDS could be a valuable auxiliary method in quality control of manufactured NPs.
Improved Frequency Sweep Keying CDMA Using Faster R-CNN for Extended Ultrasonic Crosstalk Reduction
Authors: Park Ga-Rin , Park Sang-Ho , Baek Kwang-Ryul
Published: November 2023

Ultrasonic sensors are inexpensive and can take measurements with high accuracy, even with simple hardware configurations, so they are used in various fields. When multiple ultrasonic sensors exist in the measurement space, crosstalk occurs due to other nodes, which causes measurement errors. Crosstalk includes not only receiving homogeneous signals from other nodes, but also overlap by other signals, and interference by heterogeneous signals. This paper proposes a method that uses frequency sweep keying modulation to be robust against overlap and a faster region-based convolutional neural networks (R-CNN)-based demodulator to reduce the interference caused by heterogeneous signals. The demodulator works by training faster R-CNN with the spectrograms of various received signals and classifying the received signals using a faster R-CNN. Experiments implementing an ultrasonic crosstalk environment showed that compared to on-off keying (OOK), phase-shift keying (PSK), and frequency-shift keying (FSK), the proposed method can implement CDMA even with shorter codes, and is robust against overlap. Compared to correlation-based frequency sweep keying, the time-of-flight error was reduced by approximately 75%. While existing demodulators did not consider heterogeneous signals, the proposed method ignored approximately 99% of the OOK and PSK signals, and approximately 79% of the FSK signals. The proposed method performs better than the existing methods and is expected to be used in various applications.
Conceptual Design of a Generic Data Harmonization Process for OMOP CDM
Authors: Henke Elisa , Zoch Michele , Peng Yuan , Reinecke Ines , Sedlmayr Martin , Bathelt Franziska
Published: November 2023

To gain insight into the real-life care of patients in the healthcare system, data from hospital information systems and insurance systems are required. Consequently, linking clinical data with claims data is necessary. To ensure their syntactic and semantic interoperability, the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) was chosen. However, there is no detailed guide that would allow researchers to follow a consistent process for data harmonization. Thus, the aim of this paper is to conceptualize a generic data harmonization process for OMOP CDM. For this purpose, we conducted a literature review focusing on publications that address the harmonization of clinical or claims data in OMOP CDM. Subsequently, the process steps used and their chronological order were extracted for each included publication. The results were then compared to derive a generic sequence of the process steps. From 23 publications included, a generic data harmonization process for OMOP CDM was conceptualized, consisting of nine process steps: dataset specification, data profiling, vocabulary identification, coverage analysis of vocabularies, semantic mapping, structural mapping, extract-transform-load-process, qualitative and quantitative data quality analysis. This process can be used as a step-by-step guide to assist other researchers in harmonizing source data in OMOP CDM.
On SINDy Approach to Measure-based Detection of Nonlinear Energy Flows in Power Grids with High Penetration IBR-based Renewables
Authors: Saeed Kandezy Reza , Jiang John , Wu Di
Published: November 2023

The complexity of modern power grids, exacerbated by integrating diverse energy sources, espe-cially inverter-based resources (IBRs), presents a significant challenge to grid operation and plan-ning since linear models fail to capture the intricate IBR dynamics. This study employs the Sparse Identification of Nonlinear Dynamics (SINDy) method to bridge the gap between theoretical un-derstanding and practical implementation in power system analysis. It introduces the novel Volterra-based Nonlinearity Index (VNI) to examine system-level nonlinearity comprehensively. The distinction of dynamics into first-order linearizable terms, second-order nonlinear dynamics, and third-order noise elucidates the intricacy of power systems.
The findings demonstrate a fundamental shift in system dynamics as power sources transit to IBRs, revealing system-level nonlinearity compared to module-level nonlinearity in conventional syn-chronous generators. The VNI quantifies nonlinear-to-linear relationships, enriching our comprehension of power system behavior and offering a versatile tool for distinguishing between different nonlinearities and visualizing their distinct patterns through the proposed VIN profile.
Exploring the Efficacy of AHA-BHA Infused Nanofiber Skin Masks as a Topical Treatment for Acne Vulgaris
Authors: Tören Elçin , Buzgo Matěj
Published: November 2023

Acne vulgaris is a prevalent skin condition that affects people of all ages and can have significant physical and psychological impacts. Hydroxy acids, such as alpha-hydroxy acids (AHA) and beta-hydroxy acids (BHA), have demonstrated potential as effective ingredients for topical acne treatments due to their exfoliating and skin-rejuvenating properties. This study assessed the effectiveness of encapsulating AHA and BHA in pullulan-collagen nanofibers as a novel approach to acne treatment. The study involved preparing Pullulan and polyvinyl alcohol (PVA) solutions combined with sodium chloride (NaCl) to create a stable mixture. Collagen and Pullulan were then dissolved in deionized water and mixed to form a collagen-pullulan solution. Various weight ratios of Collagen to Pullulan were tested to optimize nanofiber formation. This research achieved electrospinning of nanofibers, confirmed by scanning electron microscopy (SEM) analysis, which revealed well-formed and continuous nanofiber structures in acidic solutions. Fourier transform infrared spectroscopy (FTIR) analysis provided insights into the chemical composition of the nanofibers, indicating the presence of ester, carboxylic acid, hydroxyl, and phenolic groups. Contact angle measurements demonstrated that the pullulan-collagen nanocomposite exhibited hydrophilic properties, albeit less hydrophilic than pure Collagen. Biocompatibility assays using mesenchymal stem cells (MSCs) and human skin fibroblasts (HSFs) revealed that the pullulan-collagen nanocomposite promoted higher cell viability compared to pure Collagen, suggesting its potential as a supportive matrix for cell growth and tissue regeneration. AHA-BHA-infused nanofiber skin masks hold promise as effective topical treatments for acne vulgaris. The successful encapsulation of hydroxy acids within pullulan-collagen nanofibers, in conjunction with their favourable chemical composition, hydrophilicity, and biocompatibility, positions them as promising candidates for delivering active ingredients and enhancing skin health. Further nanofiber formulation optimisation is necessary to exploit their therapeutic potential in skincare applications.
Two Dynamic Remarks on the Chebyshev-Halley Family of Iterative Methods for Solving Nonlinear Equations
Authors: Gutiérrez José Manuel , Galilea Víctor
Published: November 2023

The aim of this paper is to deep into the dynamic study of the well known Chebyshev-Halley family of iterative methods for solving nonlinear equations. Our objetives are twofold: one the one hand, we are interested in characterize the existence of extraneous attracting fixed points when the methods in the family are applied to polynomial equations. On the other hand, we are also interested in study the free critical points of the methods in the family, as a previous step to determine the existence of attracting cycles. In both cases, we want to identify situations where the methods in the family have a bad behavior from the root-finding point of view. Finally, and joining these two studies, we look for polynomials for which there are methods in the family where this two situations happen simultaneously. That is, the rational map obtained by applying a method in the Chebyshev-Halley family to a polynomial has both super-attracting extraneous fixed point and super-attracting cycles different to the roots of the polynomial.
Online Test Instrument to Measure Students’ Critical Thinking Ability
Authors: Astuti Resti Tri , Dewi Mutia , Pratiwi Ravensky Yurianty
Published: November 2023

Penelitian ini bertujuan menghasilkan instrumen tes online untuk mengukur kemampuan berpikir kritis mahasiswa yang valid secara logis, valid secara empiris, dan reliabel. Model pengembangan dalam penelitian ini adalah model Tessmer yang terdiri dari beberapa tahap yaitu Tahap Preliminary, Self-Evaluation, Prototyping (validasi, evaluasi dan revisi) dan Field Test. Subjek uji coba penelitian ini yaitu mahasiswa semester 3 program studi Pendidikan Kimia di salah satu perguruan tinggi di Palembang. Teknik pengumpulan data yaitu tes, angket, dan wawancara. Instrumen yang digunakan yaitu lembar validasi, lembar angket respon mahasiswa dan wawancara.  Teknik analisis data yaitu analisis kualitatif dan kuantitatif menggunakan SPSS IBM 25. Hasil penelitian menunjukkan bahwa instrumen soal online untuk mengukur kemampuan berpikir kritis mahasiswa pada mata kuliah kimia analitik memenuhi kriteria. Hasil validasi ahli mendapatkan persentase sebesar 88,48% dengan kategori sangat valid. Respon mahasiswa terhadap instrumen menunjukkan soal tersebut dalam kategori praktis. Hasil validasi secara empiris diperoleh instrumen tes online sebanyak 17 soal yang valid dan 3 soal yang tidak valid. Hasil reliabilitas soal diperoleh nilah Cronbach Alpha sebesar 0,712 yang artinya instrumen tes bersifat reliabel.
Penggunaan Buku Ajar Terintegrasi STEM Terhadap Hasil Belajar Peserta Didik
Authors: Fitriyah Lina Arifah , Wardana Humaidillah Kurniadi , Af'idah Noer
Published: November 2023

Buku ajar yang digunakan sekolah pada umumnya menggunakan buku teks yang disusun pemerintah namun buku teks tersebut belum menganut pendekatan STEM. Penggunaan pendekatan STEM dalam buku ajar sebagai perpaduan disiplin ilmu sains, teknologi, teknik, dan matematika untuk kemajuan dan perluasan daya cipta peserta didik melalui proses penyelesaian masalah agar memiliki keterampilan abad 21 dan dapat bersaing secara global. Penelitian ini bertujuan mengetahui hasil belajar peserta didik yang dibelajarkan menggunakan buku ajar terintegrasi STEM. Metode penelitian yang digunakan adalah single subject research. Teknik sampel menggunakan non-probability sampling yaitu purposive sampling. Data penelitian dianalisis menggunakan uji T-Paired. Hasil penelitian menunjukkan ada perbedaan hasil belajar antara pretest dan posttest sehingga dapat dikatakan pembelajaran menggunakan buku ajar terintegrasi STEM dapat meningkatkan hasil belajar peserta didik.
THE EFFECT OF PARENTING STYLES AND LEARNING MOTIVATION ON MATHEMATICS LEARNING OUTCOMES TO FOURTH GRADE STUDENTS OF PUBLIC ELEMENTARY SCHOOLS IN PURING SUB-DISTRICT IN ACADEMIC YEAR OF 2021/2022.
Authors: Kusmiati Kusmiati , Ngatman Ngatman , Suhartono Suhartono
Published: November 2023

Penelitian ini bertujuan untuk menganalisis ada tidaknya: (1) pengaruh signifikan antara pola asuh orang tua dengan hasil belajar matematika; (2) pengaruh signifikan antara motivasi belajar dengan hasil belajar matematika; (3) pengaruh signifikan antara pola asuh orang tua dan motivasi belajar dengan hasil belajar matematika kelas IV SDN se-Kecamatan Puring tahun ajaran 2021/2022. Penelitian ini merupakan penelitian kuantitatif dengan metode regresi ganda. Pengambilan sampel dilakukan dengan teknik random sampling. Hasil penelitian menunjukkan: (1) terdapat pengaruh signifikan antara pola asuh orang tua dengan hasil belajar matematika sebesar 10,23%; (2) terdapat pengaruh signifikan antara motivasi belajar dengan hasil belajar matematika sebesar 20,77%; (3) terdapat pengaruh signifikan antara pola asuh orang tua dan motivasi belajar secara simultan dengan hasil belajar matematika sebesar 31%. Berdasarkan analisis dan hasil penelitian dapat disimpulkan bahwa terdapat pengaruh signifikan antara pola asuh orang tua dan motivasi belajar terhadap hasil belajar matematika kelas IV SDN se-Kecamatan Puring tahun ajaran 2021/2022.
Penerapan Pendekatan Realistic Mathematics Education dengan Media Konkret Dalam Peningkatan Pembelajaran Matematika Tentang Bangun Ruang di Kelas V SD Negeri 1 Adikarso Tahun Ajaran 2021/2022
Authors: Hidayah Uum Usma , Chamdani Muhamad , Wahyudi Wahyudi
Published: November 2023

Tujuan penelitian ini yaitu: (1) mendeskripsikan langkah-langkah penerapan pendekatan RME dengan media konkret dalam peningkatan pembelajaran matematika tentang bangun ruang, (2) meningkatkan hasil belajar matematika tentang bangun ruang melalui penerapan pendekatan RME dengan media konkret, (3) mendeskripsikan kendala dan solusi penerapan pendekatan RME dengan media konkret dalam peningkatan pembelajaran matematika tentang bangun ruang. Penelitian tindakan kelas ini dilaksanakan dalam tiga siklus. Subjek penelitian adalah guru dan siswa kelas V SD Negeri 1 Adikarso. Data yang digunakan berupa data kualitatif dan kuantitatif. Teknik pengumpulan data menggunakan observasi, wawancara, dan tes. Validitas data menggunakan triangulasi sumber dan teknik. Analisis data dilaksanakan melalui reduksi data, penyajian data, dan penarikan kesimpulan. Hasil belajar siswa tentang bangun ruang pada siklus I = 75,4, siklus II = 84,5, dan siklus III = 89. Dapat disimpulkan bahwa penerapan pendekatan Realistic Mathematics Education dengan media konkret pada siswa kelas V SD Negeri 1 Adikarso tahun ajaran 2021/2022.
Pengembangan E-Modul Berbasis Potensi Lokal pada Subtema Lingkungan Tempat Tinggalku Kelas IV Semester II Sekolah Dasar
Authors: Nurhayati Anis , Wahyudi Wahyudi , Suryandari Kartika Chrysti
Published: November 2023

Pembelajaran dengan mengintegrasikan potensi lokal penting dilakukan untuk mengenalkan potensi yang ada di lingkungan peserta didik. Pemilihan pengembangan e-modul berbasis potensi lokal sesuai dengan karakteristik pembelajaran tematik di sekolah dasar. Tujuan dari penelitian ini adalah: (1) untuk menjelaskan karakteristik pengembangan e-modul tematik berbasis potensi lokal, (2) menganalisis kelayakan e-modul tematik berbasis potensi lokal kabupaten Kebumen, (3) menguji keefektifan e-modul tematik berbasis potensi lokal kabupaten Kebumen. Metode penelitian menggunakan metode R&D dengan model ADDIE. Hasil penelitian ini yaitu berhasil dikembangkannya e-modul berbasis potensi lokal Hal ini dibuktikan dengan hasil penilaian dari para ahli sebesar 86,3% dengan kriteria “sangat valid”, serta dapat dilihat dari hasil perhitungan nilai n-gain sebesar 76,12% dengan kriteris efektif dan perhitungan effect size diperoleh nilai sebesar 1,92 dengan kriteria sangat besar. Kesimpulan penelitian ini adalah: (1) karakteristik pengembangan e-modul melalui beberapa tahapan, yaitu tahap analisis, tahap desain, tahap pengembangan, tahap implementasi, dan tahap evaluasi, (2) e-modul yang dihasilkan sudah teruji kelayakannya, (3) e-modul yang dikembangkan efektif untuk digunakan dalam pembelajaran. 
Penerapan Model Problem Based Learning (PBL) Dengan Multimedia Untuk Meningkatkan Hasil Belajar IPS tentang Peristiwa dalam Kehidupan pada Siswa Kelas VB SDN 4 Kutosari Tahun Ajaran 2022/2023
Authors: Salsabila Hana , Chamdani Muhamad , Susiani Tri Saptuti
Published: November 2023

Tujuan penelitian ini adalah mendeskripsikan langkah model Problem Based Learning dengan multimedia, meningkatkan hasil belajar IPS, dan mendeskripsikan kendala dan solusi yang ditemui selama pembelajaran. Subjek penelitian ini adalah siswa dan guru kelas VB SDN 4 Kutosari. Data yang digunakan berupa data kualitatif dan kuantitatif. Teknik pengumpulan data menggunakan tes dan non tes. Validitas data menggunakan triangulasi sumber dan Teknik. Analisis data dilaksanakan melalui reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan adanya peningkatan hasil belajar IPS dengan menerapkan model Problem Based Learning dengan multimedia. Persentase hasil belajar siklus I mencapai 80,77%. siklus II mencapai 88,46%, dan siklus III mencapai 92,31%. Salah satu kendala yang ditemui adalah siswa kesulitan menggunakan quizizz untuk mengerjakan evaluasi. Dapat disimpulkan bahwa penerapan model Problem Based Learning dengan multimedia dapat meningkatkan hasil belajar IPS pada siswa kelas VB SDN 4 Kutosari tahun ajaran 2022/2023.
Peningkatan Keterampilan Berpikir Kreatif pada Pembelajaran IPA Melalui Model Scientific Reading Based Project (SRBP) pada Siswa Kelas V
Authors: Fauzia Lala Ayu , Suryandari Kartika Chrysti , Susiani Tri Saptuti
Published: November 2023

Penelitian ini bertujuan untuk meningkatkan keterampilan berpikir kreatif siswa dan mendiskripsikan respon siswa terhadap penerapan model Scientific Reading Based Project (SRBP).  Penelitian ini merupakan penelitian tindakan kelas secara kolaboratif. Subjek penelitian ini yaitu seluruh siswa kelas V SDN 1 Mekarsari. Data yang digunakan berupa data kualitatif dan kuantitatif. Teknik pengumpulan data menggunakan tes, observasi, wawancara, angket, dan dokumen. Validitas data menggunakan triangulasi sumber dan teknik. Analisis data dengan reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa penerapan model Scientific Reading Based Project (SRBP) dapat meningkatkan keterampilan berpikir kreatif siswa. Siswa mampu menjawab soal dengan sejumlah jawaban, mampu menjawab dengan beberapa cara dan dari sudut pandang yang berbeda, adanya peningkatan pengetahuan siswa, dan siswa mampu mengembangkan jawaban. Respon siswa terhadap penerapan model Scientific Reading Based Project (SRBP) pada setiap siklusnya mengalami peningkatan. Hal tersebut dapat dilihat dari antusias, minat, dan semangatnya siswa ketika pembelajaran berlangsung.
Penerapan Model Project Based Learning (PjBL) dengan Media Konkret untuk Meningkatkan Pembelajaran Matematika tentang Bangun Ruang pada Siswa Kelas VA SD Negeri 4 Kutosari Tahun Ajaran 2022/2023
Authors: Hermawati Eli , Wahyudi Wahyudi , Ngatman Ngatman
Published: November 2023

Tujuan penelitian ini yaitu mengidentifikasi, meningkatkan, dan mendeskripsikan penerapan model PjBL dengan media konkret pada siswa kelas VA.  Penelitian dilaksanakan dua siklus. Subjek penelitian ini ialah guru kelas siswa VA. Data yang digunakan data kualitatif dan kuantitatif. Teknik pengumpulan data menggunakan observasi, wawancara, dan tes. Validitas data menggunakan triangulasi sumber dan teknik. Analisis data dilaksanakan reduksi, penyajian, dan kesimpulan. Hasil penelitian menunjukkan terjadi peningkatan dengan persentase ketuntasan belajar siklus I=79,63%, siklus II= 93,10%. Dapat disimpulkan bahwa penerapan model PjBL dengan media konkret dapat meningkatkan pembelajaran Matematika tentang bangun ruang pada siswa kelas VA SDN 4 Kutosari tahun ajaran 2022/2023.
The Application of Cooperative Learning (Talking Stick) with Multimedia to Improve Javanese Reading Skills to Fifth Grade Students of SD Negeri 1 Panjer in Academic Year of 2022/2023
Authors: Andini Mila Esa , Susiani Tri Saptuti , Ngatman Ngatman
Published: November 2023

The study aimed to improve Javanese script reading skills to fifth grade of SD Negeri 1 Panjer in academic year of 2022/2023 through the application of Talking Stick with multimedia. It was a collaborative Classroom Action Research conducted in three cycles. The subjects were teachers and students of fifth grade at SD Negeri 1 Panjer in academic year of 2022/2023. The data were qualitative and quantitative. Data collection techniques were observation, interviews, and tests. Data validity used triangulation of sources and triangulation of sources techniques. Data analysis included data reduction, data presentation, and drawing conclusions. The percentages of students’ passing grades in Javanese script reading skills were 72% in the first cycle, 80% in the second cycle, 92% in the third cycle. It concludes that the application of Talking Stick with multimedia improves Javanese script reading skills to fifth grade students of SD Negeri 1 Panjer in academic year of 2022/2023.
Penerapan Pendekatan Realistic Mathematics Education (RME) dengan Media Papan Pecahan untuk Meningkatkan Pembelajaran Matematika tentang Pecahan pada Siswa Kelas III SDN 2 Kalibagor Tahun Ajaran 2022/2023
Authors: Suryani Dwi Indah , Wahyudi Wahyudi , Rokhmaniyah Rokhmaniyah
Published: November 2023

Tujuan penelitian ini adalah mendeskripsikan langkah-langkah penerapan pendekatan Realistic Mathematics Education dengan Media Papan Pecahan, meningkatkan pembelajaran Matematika tentang pecahan, dan mendeskripsikan kendala dan solusi. Jenis penelitian ini yaitu penelitian tindakan kelas secara kolaboratif dengan subjek ialah guru dan siswa kelas III SDN 2 Kalibagor. Data yang digunakan data kualitatif dan kuantitatif. Teknik pengumpulan data dengan observasi, wawancara, dan tes. Validitas menggunakan triangulasi sumber dan teknik. Analisis data yang dilakukan terdiri dari reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian langkah penerapan RME terhadap guru mengalami peningkatan dari siklus I= 83,18%, siklus II= 88,33%, dan siklus III= 94,35%, sedangkan terhadap siswa setiap siklusnya mengalami peningkatan dari siklus I= 80,65%, siklus II= 85,68%, dan siklus III= 91,20%, Rata-rata persentase peningkatan hasil belajar kognitif matematika pada siklus I= 77,08%, siklus II= 89,58%, dan siklus III= 95,83%. Kendala yang dialami salah satunya siswa masih pasif. Solusi yang dapat dilakukan guru dapat menciptakan kelas yang aktif. Dapat disimpulkan bahwa penerapan pendekatan RME dengan media papan pecahan dapat meningkatkan pembelajaran matematika tentang pecahan pada siswa kelas III SDN 2 Kalibagor tahun ajaran 2022/2023.