bluuebunny/crossref_metadata_2025 huggingface dataset:
Modifiers of Somatic Repeat Instability in Mouse Models of Friedreich Ataxia and the Fragile X-Related Disorders: Implications for the Mechanism of Somatic Expansion in Huntington’s Disease
Authors: Zhao Xiaonan , Kumari Daman , Miller Carson J. , Kim Geum-Yi , Hayward Bruce , Vitalo Antonia G. , Pinto Ricardo Mouro , Usdin Karen
Published: February 2021

Huntington’s disease (HD) is one of a large group of human disorders that are caused by expanded DNA repeats. These repeat expansion disorders can have repeat units of different size and sequence that can be located in any part of the gene and, while the pathological consequences of the expansion can differ widely, there is evidence to suggest that the underlying mutational mechanism may be similar. In the case of HD, the expanded repeat unit is a CAG trinucleotide located in exon 1 of the huntingtin ( HTT) gene, resulting in an expanded polyglutamine tract in the huntingtin protein. Expansion results in neuronal cell death, particularly in the striatum. Emerging evidence suggests that somatic CAG expansion, specifically expansion occurring in the brain during the lifetime of an individual, contributes to an earlier disease onset and increased severity. In this review we will discuss mouse models of two non-CAG repeat expansion diseases, specifically the Fragile X-related disorders (FXDs) and Friedreich ataxia (FRDA). We will compare and contrast these models with mouse and patient-derived cell models of various other repeat expansion disorders and the relevance of these findings for somatic expansion in HD. We will also describe additional genetic factors and pathways that modify somatic expansion in the FXD mouse model for which no comparable data yet exists in HD mice or humans. These additional factors expand the potential druggable space for diseases like HD where somatic expansion is a significant contributor to disease impact.
FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders
Authors: Deshmukh Amit L. , Porro Antonio , Mohiuddin Mohiuddin , Lanni Stella , Panigrahi Gagan B. , Caron Marie-Christine , Masson Jean-Yves , Sartori Alessandro A. , Pearson Christopher E.
Published: February 2021

FAN1 encodes a DNA repair nuclease. Genetic deficiencies, copy number variants, and single nucleotide variants of FAN1 have been linked to karyomegalic interstitial nephritis, 15q13.3 microdeletion/microduplication syndrome (autism, schizophrenia, and epilepsy), cancer, and most recently repeat expansion diseases. For seven CAG repeat expansion diseases (Huntington’s disease (HD) and certain spinocerebellar ataxias), modification of age of onset is linked to variants of specific DNA repair proteins. FAN1 variants are the strongest modifiers. Non-coding disease-delaying FAN1 variants and coding disease-hastening variants (p.R507H and p.R377W) are known, where the former may lead to increased FAN1 levels and the latter have unknown effects upon FAN1 functions. Current thoughts are that ongoing repeat expansions in disease-vulnerable tissues, as individuals age, promote disease onset. Fan1 is required to suppress against high levels of ongoing somatic CAG and CGG repeat expansions in tissues of HD and FMR1 transgenic mice respectively, in addition to participating in DNA interstrand crosslink repair. FAN1 is also a modifier of autism, schizophrenia, and epilepsy. Coupled with the association of these diseases with repeat expansions, this suggests a common mechanism, by which FAN1 modifies repeat diseases. Yet how any of the FAN1 variants modify disease is unknown. Here, we review FAN1 variants, associated clinical effects, protein structure, and the enzyme’s attributed functional roles. We highlight how variants may alter its activities in DNA damage response and/or repeat instability. A thorough awareness of the FAN1 gene and FAN1 protein functions will reveal if and how it may be targeted for clinical benefit.
Renal Function: Implications on the Surgical Treatment of RCC
Authors: Janetschek Günter
Published: February 2021

The good oncologic results after partial nephrectomy for stage 1 RCC show that radical nephrectomy is an overtreatment in most cases, and that many healthy nephrons are removed unnecessarily. However, partial nephrectomy is a difficult operation, with increased blood loss and a higher risk of complications. Therefore, the advantage of preserved function has to be weighed up against the increased trauma of surgery in each individual patient, and the assessment of preoperative function may influence this decision, among other factors such as comorbidities and age.

In most studies, renal function has been assessed by means of estimated glomerular filtration rate, and this parameter is very helpful for long-term studies in large populations. However, more precise measurement based on clearance studies are sometimes required for more sophisticated investigations.

The technique of partial nephrectomy has evolved substantially in recent years, resulting in the preservation of more nephrons, less damage to the remaining parenchyma, less blood loss, and a decreased risk of complications. The introduction of minimally invasive surgery for this purpose has also decreased the overall morbidity of surgery.

In the long-term, chronic kidney disease may result in increased cardiac mortality. There is ongoing discussion on this problem, however, this potential negative influence on overall survival is not only influenced by the rate of renal insufficiency, but also to a great extent by other comorbidities such as hypertension and diabetes. Therefore, in addition to providing the best surgery for any given patient, we have to make sure that the treatment of the comorbidities will also be part of our patient management, since the risk of cardiac failure may be greater than the risk of poor oncologic outcome.
The Need for an Integrated Approach to Reducing Young People’s Risk of Homelessness and HIV in Pakistan
Authors: Noor Muhammad Naveed
Published: February 2021

Background: Past research demonstrated a link between homelessness and the increased risk of HIV and other sexually transmitted infections (STIs). However, ways to reduce young people’s risk of homelessness and sexual health risks have not been adequately addressed. This paper, based on the first detailed sociological exploration into the lived experiences of homeless young people, argues for the adoption of a holistic and integrated approach to health promotion that goes beyond the health sector.
Methods: In-depth interviews were conducted with twenty-nine homeless young people, aged 16-25-year-old, from Rawalpindi, Pakistan.
Results: A combination of socio-structural and interpersonal forces shaped participants’ pathways to homelessness and their experiences of street life – notably regarding sex work – and produce contexts of competing risks where HIV/STIs prevention became a secondary concern. Participants had a reasonable knowledge regarding nature, transmission, prevention, and to some extent, treatment of HIV/STIs. Nevertheless, this knowledge did not help them much, as most of the participants used condoms inconsistently with clients and intimate partners. Financial considerations, fear of violence from clients, and social obligations in intimate partnerships contributed to participants inconsistent condom use, increasing their risk of HIV/STIs.
Conclusion: The results indicate the importance of the Ottawa Charter of health promotion, which suggests that conventional health promotion approaches are potentially suboptimal in shaping health behaviours supportive of good health. Notably, building healthy public policies, creating supportive environments, strengthening community actions, developing personal skills, and reorienting health services can help to improve young people’s socioeconomic status, which is inextricably linked with sexual health behaviour and status.
E-Learning: A Panacea during COVID- 19 Crisis
Authors: Khalid Atiqa
Published: February 2021

Institute closure strategies were imposed during the COVID-19 pandemic worldwide to mitigate the rapid infection and transmission rate. E-learning was adapted as an alternative to traditional physical learning to keep the students safe from this infectious virus. While most of the countries have adopted this system, many under-developed and developing countries including Pakistan are not practicing the online system of E-learning as the biggest challenge to e-learning providers and policymakers is the provision of equal access to electronic-based learning to students from underprivileged backgrounds who have limited access to internet facility outside the learning institutions. School closure strategies during the COVID-19 pandemic must be based on equivocal evidence while implementing social distancing measures. If restrictive social distancing policies are to be imposed for a considerable period, other, less disruptive social distancing modes should be considered. The online learning system was a crucial step to balance academic loss in medical education. But our medical institutes are ill-equipped in implementing e-learning effectively. Authorities should devise ways to make e-learning more user-friendly.
Portafolio virtual en la gestión pedagógica del docente universitario en salud
Authors: Azúa Menéndez Marieta Del Jesus , San Lucas Marcillo Marianela , Anzules José Tigua
Published: February 2021

La presente investigación se realizó en la Universidad Estatal del Sur de Manabí, básicamente a los docentes Universitario de Salud. Tiene como propósito indagar la relación entre la elaboración de portafolios electrónicos y el proceso de enseñanza aprendizaje, desde la experiencia de los docentes de la Carrera de Laboratorio clínico, mejorando la evaluación de aprendizaje en los estudiantes de la carrera en mención. Mediante ésta investigación se determinó el nivel de uso del portafolio docente como evidencia de aprendizaje por competencias, proponiendo una solución al problema. El proceso de innovación del docente universitario en el aula permite alcanzar un principal objetivo formativo que es: promover que los estudiantes desarrollen conocimientos científicos rigurosos, integrados y aplicados en su desempeño profesional; fomentando en ellos la capacidad de ser aprendices autónomos y autorregulados; y participar en el fortalecimiento de alumnos críticos, reflexivos y creativos. Se utilizó una metodología hipotético-deductiva, cuyo análisis se orientó por las nociones de aprendizaje situado y aprendizaje reflexivo. Desde la perspectiva del estudiante, los resultados muestran que esta herramienta didáctica es valorada como sistema integrado de enseñanza aprendizaje - evaluación de competencias profesionales. No obstante, viene determinada por el dominio progresivo de los contenidos en formato digital. En conclusión, el portafolio es un instrumento idóneo para la adquisición de competencias vinculadas a los métodos de investigación en educación, ya que al tomar el alumno conciencia de su proceso de aprendizaje desarrolla su capacidad de autorregulación, acercándose progresivamente a un aprendizaje autónomo y responsable.
Proyectos de Investigación
Authors: De Enfermería Escuela
Published: February 2021

Proyectos de Investigación
Internado una gran experiencia
Authors: Potosí Marlene
Published: February 2021

El Internado una gran experiencia
Seedlings morphology of confectionery sunflower at different pH of water solution
Authors: Varga Ivana , Antunović Manda , Dobreva Tsvetelina , Iljkić Dario , Šoštarić Jasna
Published: February 2021

In this study the confectionery sunflower seed was tested to germination at different pH media, from 3.5 to 8.5. The experiment was set up at room temperature (22°C) and at 24 h dark conditions for 10 days. The mean germination rate was 76%. The highest germination rate was 86% at pH 3.5, whereas the lowest was 68% at pH 5.5. The ANOVA resulted with very significant influence of pH on sunflower seedlings root, stem and total length (p<0.001). The total length of seedlings was the shortest at acid media (9.2 cm at 3.5) and the longest at alkaline media (12.5 cm at pH 8.5). Regression equitations showed that increment of stem or root length and total length have a positive trendline at all pH levels. It was found that the alkaline water solution has a positive influence on protein sunflower seedlings development, but it would be valuable to found how the seeds would germinate at the field conditions.
Standardization of terminology in SIBID
Authors:   Russian National Public Library for Science and Technology (RNPLS&T), Zaitseva Ekaterina M.
Published: February 2021

Standardization of terminology in the System of Standards on Information, Librarianship and Publishing (SIBID) is discussed. SIBID interstate and national terminological standards are examined; the problems of standards thematic distribution are analyzed. Some contraventions of structuring terminological system are revealed, and solutions are suggested.
Library education models and pathways in the digital economy
Authors:   Moscow State Institute of Culture, Lopatina Natalya V.
Published: February 2021

Crucial questions of library and information education in the circumstances of digital economy are formulated. Factors to impact the pathways of library and information education are defined. The current trends in higher education influencing the models and pathways of library and information education, library profession and sector development within the digital economy, are revealed.
Pathological and anatomical diagnosis of an ostrich spontaneou death (clinical case)
Authors: Khomenko Z. , Guralska S. , Zaika S. , Kot T. , Sokulskiy I.
Published: February 2021

Ostriches tolerate extreme environmental conditions well. The reserve of their adaptive abilities is very high. These birds retain heat well in cold weather, covering their large legs with their large feathers, as well as in the heat, fluttering them to create coolness. As the experience of keeping ostriches on farms in Europe and Ukraine shows, they can withstand temperature to -15 °C, and in the African deserts- temperatures up to +56 °C. Therefore, given the climatic conditions in Ukraine, this branch of poultry, in fact, has the right to be realized and profitable. Due to the growth and development of ostrich farms in Ukraine and the significant lack of literature about the diseases of these birds, which are kept in private farms, zoos, the result of this study will be useful to get a general idea of the digestive system of ostriches and possible pathology, which is related to anatomical features of the digestive system of these birds. The ostrich autopsy was performed in the section hall of the Department of Anatomy and Histology of Polissya National University. Morphological data were analyzed and discussed to establish the etiology of the disease, postmortem diagnosis and cause of the animal’s death. Analyzing the results, it can be argued that the animal died as a result of hypothermia (as much of its body was deprived of feathers) and feeding it large, hard pieces of food, including fodder beets. The autopsy revealed a significant overflow of the stomach with feed masses, a large number of stones, leaves, grass and large pieces ofundigested beets, blockage of the pyloric orifice, which led to acute gastric enlargement, resulting in acute venous stasis in the lungs and liver, developed pulmonary and brain edema. The animal death occurred as a result of asphyxia. The results of the research can be used for comparative pathology of diseases of this species of birds.
Key words: ostrich, stomach, pyloric orifice, intestine, lungs, liver, kidneys, venous stasis.
Geoinformation analysis of rabies spread in Vinnytsya region
Authors: Makovska I. , Bezymennyi M. , Nedosekov V. , Kornienko L. , Tsarenko T. , Melnyk V. , Martyniuk O. , Zhukovskyi M.
Published: February 2021

This paper presents the results of a geoinformation analysis of the spread of rabies in Vinnytsia region during 2018. The material for the study was the official data from the report of the region laboratory of veterinary medicine of the State Food and Consumer Service of Ukraine. GIS analysis was performed using Quantum GIS software version 3.4.10. The highest incidence of rabies among foxes was observed in the autumn-winter period, especially in November and December. Among cats and dogs, elevated rates were observed from October to May (with a predominance in January-March). Among farm animals, the disease progressed in summer and to a greater extent in early autumn (SeptemberOctober). Outbreaks of rabies in other wild animals were not synchronously associated with fox disease and were reported in winter only in January, during spring (mainly in May) and in early summer. Calculated using standard deviations ellipses, the spatial trends of rabies distribution among different animal species show that the vast majority of rabies cases among foxes were localized in the centre of the region along the western border; among cats more compact, closer to the northern border; among dogs, cases of rabies were scattered throughout the territory and distributed along the northeastern border; among farm animals were localized only in the northern part of the region; among other wild animals were registered almost throughout the region. The identification of "hot spots" allowed to establish zones of maximum rabies density with a rate of 27.8 casesof rabies per km2 for all species of animals. For foxes, the zones of the highest density (17.9 cases per km2) were mainly localized in the areas near Khmelnytsky, Zhytomyr and Cherkasy regions. For cats (9.12 cases per km2) they covered the territories of the central and north-eastern districts. For dogs (9.12 cases per km2) only in the north-eastern regions. For farm animals (9 cases per km2) the location of the hotspots coincided with the areas for cats. Among other wild animals, the highest density (3.71 cases per km2) was recorded in the southern part of the regions. The prospect of further research is based on modeling the dynamics of rabies in the Vinnytsia regions. Key words: GIS analysis, rabies of wild animals, rabies of domestic animals, epizootic situation, rabies in Ukraine.
Concentration of C-reactive protein and haptoglobin in cows with subclinical endometritis
Authors: Basarab T. , Stefanyk V. , Ivakhiv M. , Niżański W.
Published: February 2021

Acute phase proteins are blood components synthesized by hepatocytes, basic function of which is to defend the organism as part of the immune response to inflammation, trauma, infection, stress, neoplasia. They trigger a complex systemic reaction in order to restore homeostasis recovery of the organism. Proinflammatory cytokines increase their activity in response to the effect of pathogenic microorganisms which are intense stimulants to the production of acute phase proteins. It is known that postpartum uterine contamination is common among many cows. Normally, infections and inflammations are eliminated by the immune response of the uterus. However, about 40% of dairy cattle develop clinical metritis. The aim of this study was to determine changes of C-reactive protein and haptoglobin concentration in healthy cows and with subclinical endometritis. The study was conductedat NNVTS "Komarnivsʹkyy" Horodok district, Lviv region. Two groups of cows of Ukrainian blackand-white dairy breed, aged from 4 to 7 years old, were investigated. The control group included twenty (n = 20) clinically healthy cows. Experimental group included twenty (n = 20) cows with subclinical endometritis. It was found that in the blood serum of healthy cows C-reactive protein concentration was 11,25±1,07 µg/ml. Significant increase (P˂0,001) of C-reactive protein concentration in cows with subclinical endometritis (72,57±18,11 µg/ml) was observed. In the blood serum of healthy cows haptoglobin concentration was 22,5±5,50 mg/l. Significant increase (P ˂0,001) of C-reactive protein concentration in cows with subclinical endometritis (72,57±18,11 µg/ml) was observed. In the blood serum of healthy cows haptoglobin concentration was 22,5±5,50 mg/l. Significant increase (P ˂0,001) of C-reactive protein concentration in cows with subclinical endometritis (72,57±18,11 µg/ml) was observed. In the blood serum of healthy cows haptoglobin concentration was 22,5±5,50 mg/l. Significant increase (P <0,001) of haptoglobin concentration in cows with subclinical endometritis (771,5±122,66 mg/l) was observed. The presented study shows that in cows with subclinical endometritis, increase of C-reactive protein and haptoglobin was observed. Determination of concentration of these proteins can be an informative indicator of subclinical inflammatory process in the uterus of cows. In future research it is important to determine change of IL and TNF-a expression depending on the condition of the uterus.
Key words: acute phase proteins, C-reactive protein, haptoglobin, subclinical endometritis, dairy cattle, uterus.
Comparison of McMaster and Mini-FLOTAC eﬃ ciency methods in diagnostics of Ascaris suum infection in young pigs
Authors: Kruchynenko O. , Antipov A.
Published: February 2021

The coproovoscopic methods involving count chambers are widely used in the veterinary practice for diagnostics. These methods are important in assessments of the prevalence rates of nematode infections in pigs and for FECR tests. However, more basic data is needed on the efficiency of the commercial methods of diagnostics, tested at the different specific gravity of the flotation solutions. In a thorough analysis of publications of Ukrainian scientists, we have found that the data is sparse on the efficiency comparison of the modified McMaster’s and MiniFLOTAC methods. The aim of our study was to compare the efficiency of the commercial coproovoscopic techniques: the modified McMaster’s method (with sensitivity of 25 EPG), and MiniFLOTAC combined with Fill-FLOTAC (with sensitivity of 5 EPG) in testing for A. suum infection in piglets. Results of approbation of the mentioned methods are presented for the following saturated solutions: NaCl (SG=1.2), MgCl2 •6H2 O (SG =1.27) and NH4 NO3 (SG=1.28). Fecal samples were taken at own private farm, in Mlynok village of Onufriivka district, Kirovohrad region from 20 4 month old pigs with spontaneous A. suum infection. The laboratory assessments were performed in the Scientific Laboratory of Parasitology and Veterinary and Sanitary Expertise of the Poltava State Agrarian Academy. It is established that at high rates of A. suum infection in young pigs, McMaster’s method with the ammonium nitrate solution is more efficient compared to the Mini-FLOTAC method. In average, 5331.2 eggs of A. suum were determined per 1 g of feces using the former method, compared to 4567.5 EGP according to the Mini-FLOTAC technique (P < 0.001). The highest diagnostic efficiency of the modified McMasters method and the combination of Mini-FLOTAC and Fill-FLOTAC is seen when ammonium nitrate (NH4 NO3 ) solution of 1.28 SG is used (P < 0.001). Our results add new data on the efficiency of the commercial methods of diagnostics with varying specific gravity of the flotation solutions, for pigs infected with nematodes.
Key words: EPG, pigs, nematode, ascariasis, diagnostics, efficiency.
Organizational and economic relations in the chain supply of milk and dairy products
Authors: Paska I. , Grinchuk Yu. , Artimonova I.
Published: February 2021

The article discusses the organizational and economic relations between the participants in the supply chain of milk and dairy products. Generally, organizational and economic relations are a set of relations between the participants of the dairy products chain, which are formed in the process of production, distribution and sale to consumers, as a result of which the economic interests of all its participants are realized. The peculiarities of dairy products of the chain are systematized and the basic principles, conditions for their balanced development are determined, contributes to the coordination of the economic interests of all its participants.
It has been proved that economic interest is an important component of organizational and economic relations in the supply chain of milk and dairy products, and its main elements are: prices for raw materials and fnished products, costs of production, processing of raw materials, transportation, terms of mutual settlements, material interest of personnel, norms of fulfllment of contractual obligations, risks and the like. Review of the negative factors of organizational and economic relations in the dairy product chain and their impact on the eﬀectiveness of each of its participants. As a tool to increase the production of raw milk, it is proposed to optimize the raw material zones of dairy processing enterprises, develop strategic programs for the development of the industry and stimulate consumer demand, as well as create industry clusters.
The calculations for the distribution of costs and income between participants in the supply chain of milk and milk products prove the need to ensure the equivalence of exchange. In order to improve the efciency of the researcher, it was proposed to increase the volume of milk production and processing, as well as to establish mutually benefcial relations between its participants, connected by a single production cycle. The directions of innovation and investment development of the participants in the dairy products chain, especially the link of dairy cattle breeding, are highlighted. It is highlighted that the innovative renewal of the activities of the chain participants is a process of cyclical activities focused on the production of competitive dairy products of a new generation, which will contribute to an increase in turnover in order to obtain the highest proft of the chain participants and satisfy the demand of consumers with diﬀerent income levels.
Key words: dairy products chain, chain participants, exchange equivalence, organizational and economic relations.
A newly recorded crab-spider genus Misumenoides F.O. Pickard-Cambridge, 1900 (Araneae: Thomisidae) from Khulna, Bangladesh
Authors: Biswas V
Published: February 2021

A study on the crab-spider genus Misumenoides F. O. Pickard-Cambridge, 1900 (Araneae: Thomisidae) was carried out in Khulna, Bangladesh. One species namely – M. deccanes Tikader was recorded for the first time from the present study area. Illustrated description and distribution of the species are provided together with generic diagnosis.

J. Biodivers. Conserv. Bioresour. Manag. 2020, 6(1): 77-82
Evaluation of Closure versus Non-closure of Vaginal Vault after Non-descent Vaginal Hysterectomy
Authors: Saha Mousumi , Rahman Ratu Rumana Binte , Ara Gulshan , Rahman Florida , Jahan Raunak
Published: February 2021

Introduction: Non-descent vaginal hysterectomy has been considered a valid alternative to the abdominal approach and is also preferred for benign uterine diseases without descent of uterus because it is associated with fewer complications. Vaginal vault is the enlargement of the internal end of the vagina which is usually closed during vaginal hysterectomy. This study was done to see the outcome of vault closure versus non-closure in non-descent vaginal hysterectomy in non-prolapsed uterus.

Methods: This prospective study was done in Obstetrics and Gynae Department, Sir Salimullah Medical College and Mitford Hospital during the period of July 2011 to December 2011. A total number of 50 patients with benign gynecological disorders without descent of uterus who admitted for hysterectomy were enrolled in this study. Among them, 25 patients had the vault close (group I) whereas 25 patients had an open vault(group11). Indication for hysterectomy, complications, blood transfusion, hospital stay (day) and histopathological findings were assessed for both groups. Statistical analyses of the results were obtained by using window based computer software devised with Statistical Packages for Social Sciences (SPSS-20).

Results: Majority of the patients was found in the age group of 41-45 years in both groups, which was 12(48.0%) in Group I and 18(72.0%) patients in Group II. Blood transfusion was needed in 5(20.0%) and in 6(24.0%) in Group I and Group II respectively. Post operative complications after 15 days of follow-up, pelvic abscess was found 4.0% in Group I & not found in Group II. UTI was not found in Group I but 4.0% found in Group II.

Conclusion: Outcomes were almost similar in both procedure. Ultimately the study did not show any significant difference between either group.

J Shaheed Suhrawardy Med Coll, December 2020, Vol.12(1); 45-49
Cómo dialogar en la planificación local del patrimonio cultural. Tres experiencias en la isla de Tenerife
Authors: Benítez Méndez Carlos Antonio
Published: February 2021

¿Cómo podrían converger el conocimiento experto, la gestión técnica y política, y el saber de las personas y los colectivos culturales en la planificación local del patrimonio cultural? ¿Qué metodologías e instrumentos podríamos usar para avanzar hacia un modelo de participación activa en las decisiones públicas, es decir, de gobernanza participativa del patrimonio cultural? Este artículo intentará aportar un conjunto de experiencias de planificación en la isla de Tenerife basadas en la creación de espacios colectivos de diálogo como un instrumento eficaz para la reflexión, el diagnóstico y la toma de decisiones sobre el patrimonio cultural municipal incorporando la pluralidad de actores y perspectivas sobre el mismo para alcanzar una visión común. El protagonismo de las comunidades en la gestión de su patrimonio cultural ha sido, de hecho, reconocido por organizaciones como la Unesco o la Unión Europea, mientras que el «giro dialógico» (AUBERT, A; Flecha, A.; García, C.; et ál., 2013) del tiempo actual está desplazando las relaciones autoritarias por otras sustentadas en el diálogo y en la búsqueda de consenso en todos los órdenes de la sociedad, como en la propia forma de generar conocimiento o de tomar decisiones en el ámbito público. Metodologías participativas como las del World Café nos han ofrecido, en este sentido, una oportunidad para facilitar el diálogo sobre el patrimonio cultural en un contexto de igualdad entre los distintos actores de la comunidad en tres municipios de la isla de Tenerife como son Tegueste, Candelaria y Santiago del Teide.
La Casa del vecino. Tipos y evolución en la arquitectura doméstica tradicional del Guadiana portugués
Authors: Costa Rosado Ana , Pérez Cano María Teresa , Reimão Costa Miguel
Published: February 2021

La arquitectura doméstica refleja, mejor que ninguna otra, la cultura de un lugar, las costumbres, las vivencias de sus gentes. Se rige por las directrices de su territorio, los terrenos, los materiales, los condicionantes climáticos y por eso, ni puede ser estudiada fuera de su contexto, ni el paisaje de un lugar se explica sin su arquitectura vernácula. Pero ¿y cuándo de un mismo territorio físico resultan modelos dispares? Este artículo revisa la casa tradicional del Alentejo portugués, concretamente, el margen izquierdo del Guadiana, a través de levantamientos in loco y el estudio de documentación de archivo. Se presenta como caso de estudio la ciudad de Moura, donde el análisis de 143 casos ha permitido establecer una línea de evolución de la vivienda y definir varias categorías de tipos de casa tradicional. Se presentan estos tipos, sus materialidades, las técnicas constructivas de la región y una similitud transfronteriza. Si por el mismo contexto histórico y territorial, las afinidades de ocupación territorial y urbana entre el Guadiana portugués y la Baja Extremadura/Sierra de Aracena resultan casi obvias, resultarán más sorprendentes las diferencias que experimentará la evolución de la vivienda entre los dos márgenes del Guadiana.
Martinell, A. (dir.) Cultura y desarrollo sostenible. Aportaciones al debate sobre la dimensión cultural de la Agenda 2030
Authors: Sanchez Gabriela
Published: February 2021

Reseña del libro Martinell, A. (dir.) Cultura y desarrollo sostenible. Aportaciones al debate sobre la dimensión cultural de la Agenda 2030. Madrid: REDS, 2020
O cotidiano das enfermeiras na oncologia pediátrica
Authors: Pacheco Patrícia Quintans Cundines , Souza Sônia Regina de , Tocantins Florence Romijn , Silva Leila Rangel da , Pinheiro Izabela da Silva
Published: February 2021

Objetivos: Analisar as dimensões ação e afeto no contato cotidiano das enfermeiras na oncologia pediátrica e discutir as implicações das dimensões ação e afeto na prática das enfermeiras na oncologia pediátrica. Método: Estudo qualitativo a luz do referencial teórico de cotidiano de Agnes Heller.  Participaram do estudo 21 enfermeiras selecionadas pela técnica de amostragem Bola de neve. Os dados foram produzidos por entrevista semiestruturada mediada por produção artística baseada na técnica de criatividade e sensibilidade e submetidos à análise temática. Resultados: Nas ações das enfermeiras se interpenetraram a especialidade oncologia e as especificidades da criança. Na dimensão afeto constatou-se uma inclinação, atitude de proteção da enfermeira para a criança e sua família diante da ruptura de vínculos e da copresença da morte resultando em compaixão. Conclusão: Para as enfermeiras, o contato cotidiano na oncologia pediátrica foi desafiante e as potencialidades se mostraram limitadas devido à demanda emocional gerada pela empatia e pelo envolvimento pessoal na assistência às crianças e suas famílias, gerando desgaste profissional e fadiga por compaixão.
Como se articulam a Psicologia Positiva e a Psicologia da Saúde?
Authors: Figueiredo Camilla Vieira de , Moura Hysla Magalhães de , Rezende Alessandro Teixeira , Moizéis Heloísa Bárbara Cunha , Guedes Italo de Oliveira , Curvello Roberta Pereira
Published: February 2021

O presente artigo objetivou discutir a interface entre a Psicologia Positiva e a Psicologia da Saúde, destacando a relevância dos estudos e intervenções sobre os aspectos positivos e favoráveis ao pleno funcionamento e desenvolvimento dos seres humanos. Para tanto, foi realizada uma revisão narrativa da literatura científica sobre como se articulam teoricamente essas áreas. Como resultados, a literatura tem mostrado que o interesse por estudar as qualidades, motivações e potencialidades humanas tem aumentado nos últimos anos no Brasil e no mundo e que isto se deve, em grande parte, aos avanços promovidos pelo campo da Psicologia Positiva. Esta área tem marcado uma mudança gradual na forma de compreender os indivíduos e suas relações intra e interpessoais, propondo um equilíbrio na abordagem dos aspectos positivos e negativos da conduta humana, visto que historicamente a Psicologia deu mais ênfase à investigação dos últimos. Desse modo, a Psicologia Positiva vem oferecer um olhar mais aprofundado em relação aos fatores protetivos e preventivos da saúde humana. Nessa direção, discute-se que a Psicologia da Saúde se articula com a Psicologia Positiva e que ambas assumem perspectivas de investigação-ação e de intervenção psicológica com vistas à promoção da saúde e do bem-estar biopsicossocial, bem como à redução e prevenção de sintomas patológicos.
“Ninguém está falando em liberação da droga”: ressignificação da maconha nos programas matinais das redes Globo e Record
Authors: Rodrigues Ana Paula Lopes da Silva , Lopes Ivonete da Silva , Mourão Victor Luiz Alves
Published: February 2021

O uso medicinal e terapêutico da Cannabis spp. tem uma longa história na humanidade, mas a atual Política Nacional de Drogas do Brasil ainda impõe processo burocrático para plantio, produção e consumo da substância para fins medicinais. Esse artigo tem o objetivo de analisar e comparar como programas de entretenimento matinais das redes Globo e Record abordaram o uso medicinal dos derivados da maconha no Brasil entre 2014 e 2018, nas quais são destaques os movimentos sociais a favor da liberação da maconha medicinal para famílias de pacientes que não respondem aos tratamentos convencionais. Observou-se mudança significativa na abordagem, no que tange à seleção lexical, das emissoras durante o processo de liberação da importação. A segunda modificação observada consiste na escolha das fontes para as entrevistas. Se num primeiro momento tem-se forte representação das famílias, construindo uma imagem familiar do uso da substância, com o passar do tempo essas são substituídas por médicos e neurocientistas.
Uma prática de leitura contemporânea para adolescentes e jovens
Authors: Machado Katya Karina Figueiredo , Folmer Vanderlei , Balk Rodrigo de Souza
Published: February 2021

Este artigo visa apresentar resultados de uma pesquisa bibliográfica acerca da importância da leitura pelo público adolescente e jovem. Esse estudo objetiva fomentar o incentivo a essa prática, para que os sujeitos compreendam melhor o mundo e a si mesmos, tornando-se mais humanizados e felizes.  Na metodologia foi realizado um levantamento bibliográfico, seguido de consultas a diferentes fontes de leitura. Obteve-se como resultado ideias de diferentes autores que mostram que na leitura literária há um vínculo entre os sujeitos e a aplicação dos direitos humanos, desde que ajam com protagonismo e autonomia. Também, mostra uma análise quanto ao tipo de linguagem destinada ao público jovem, estabelecendo relações de proximidade dele com a leitura, apresentando, dessa forma, algumas sugestões de obras que podem ser lidas pelos adolescentes, cumprindo com a função, não só de divertir, mas de lhes apresentar novas ideias de convivência em sociedade. Além disso, mostra a facilidade com a qual a Internet está ocupando os espaços na vida das pessoas, interagindo de forma invasiva entre adolescentes e jovens, trazendo novidades que encantam, mas que também escravizam; são as adaptações modernas que seduzem, atraem, facilitam, mas exigem muito tempo, espaço e capacitação dos envolvidos. Foi possível concluir que a leitura é um tema muito abordado pelos autores, dada sua importância para o crescimento humano. Espera-se que essas ideias sirvam de inspiração para qualquer pessoa que deseje ser um facilitador para a formação de um mundo mais leitor.
El dolor orofacial y su relación con la hipocalcemia asociada a la enfermedad renal crónica: un diagnóstico diferencial pasado por alto
Authors: Santos Anderson Maikon de Souza , Barbosa Stéfany , Palin Letícia Pitol , Silva William Phillip Pereira da , Santos João Matheus Fonseca e , Machado Nathália Evelyn da Silva , Lima Neto Tiburtino José de , Rios Barbara Ribeiro , Vieira Eduardo Hochuli , Faverani Leonardo Perez
Published: February 2021

Aunque el dolor orofacial es una condición de etiopatogenia multifactorial y en ocasiones es difícil de diagnosticar, una posible causa de esta condición son los cambios musculares, que a su vez pueden originarse en condiciones sistémicas, como la hipocalcemia. El presente artículo tiene como objetivo presentar una situación clínica de dolor orofacial por hipocalcemia en una paciente joven con enfermedad renal crónica. El paciente acudió a atención hospitalaria con fuertes quejas de dolor en el rostro, siendo evaluado por el equipo de Cirugía Maxilofacial y el equipo médico de Neurología, sin la determinación precisa de una etiología. A pesar de que se le prescribió medicación oral, el paciente regresó con la queja de dolor y con un nuevo síntoma de calambres en el rostro, ante lo cual se solicitó pruebas hematológicas donde se encontró una condición de hipocalcemia. El enfoque terapéutico consistió en suplementos de calcio por vía oral, que fue suficiente para suprimir las molestias faciales. Se concluye que existe una correlación entre la concentración de calcio en sangre y los cambios musculares en el rostro, requiriendo estudios clínicos para explicar mejor esta relación.
Fatal footsteps: Understanding the Safe System context behind New Zealand’s pedestrian road trauma
Authors: Hirsch Lily , Mackie Hamish , McAuley Iain
Published: February 2021

In 2016 in New Zealand, pedestrians accounted for 7.6% (n=25) of all road fatalities and 6.6% (n=257) of serious injuries (Ministry of Transport, 2017). The aim of this research was to analyse a sample of pedestrian deaths and serious injury (DSI) cases to understand the contribution of Safe System gaps in serious harm outcomes. A sample of 100 pedestrian fatality and 200 serious injury crash reports from 2013-2017 were analysed to identify the contribution of the four Safe System pillars (roads and roadsides, vehicle, speed environment, user) in each crash case. The research identified common crash scenarios and highlighted the need for improvements in speed management, safer vehicles, safety campaigns, and infrastructure design. In addition, the research identified latent high-order sociotechnical system factors that obstruct the mechanisms to effectively address these Safe System issues and which ultimately perpetuate the occurrence of pedestrian DSIs.
Kineziterapija gydant nudegimų traumas. Literatūros apžvalga
Authors: Siparytė-Sinkevičienė Brigita , Rimdeika Rytis
Published: February 2021

Pagrindimas. Sergamumas nudegimais susijęs su ilgu gydymo laikotarpiu ir negalia. Nudegimų trauma dėl hipermetabolinio atsako pažeidžia daugelį organizmo funkcijų ir pasireiškia raumenų masės ir raumenų jėgos sumažėjimu, kontraktūrų išsivystymu. Nustatyta, kad kineziterapijos taikymas didina fizinį pajėgumą, raumenų jėgą, gerina kūno kompoziciją ir gyvenimo pilnatvę.

Tikslas – išanalizuoti mokslinę literatūrą apie nudegimų traumos poveikį įvairioms organizmo sistemoms ir kineziterapijos veiksmingumą ligoniams, patyrusiems nudegimų traumą.

Metodai. Buvo apžvelgta literatūra. Duomenys surinkti iš duomenų bazių PubMed, ScienceDirect, ClinicalKey. Straipsniai publikuoti tarp 2009 ir 2020 metų. Ieškoma su šiais raktažodžiais: nudegimų trauma, kineziterapija, pratimai, raumenų jėga, reabilitacija. Atrinkti ir išanalizuoti 36 straipsniai, atitinkantys nagrinėjamą temą.

Rezultatai. Vienas iš svarbiausių žingsnių reabilitacijos metu po nudegimų traumos yra pratimai, taikomi atgauti judesių amplitudę sąnariuose, didinti raumenų jėgą ir ištvermę, apsaugoti nuo trombembolijų komplikacijų, susigrąžinti fizinę ir psichologinę sveikatą. Kineziterapija taikoma visose nudegimų traumos gydymo fazėse, tačiau nagrinėtuose straipsniuose taikomi įvairūs mobilumo, jėgos, ištvermės, judesių amplitudės didinimo pratimai. Skausmui mažinti taikomi pratimai pasitelkiant virtualią realybę, diafragminį kvėpavimą ir muzikos terapiją. Kontraktūrų prevencijai taikomas gydymas padėtimi ir įtvarai.

Išvados. Pratimai yra pagrindinė ir saugi kineziterapijos priemonė po nudegimų traumos visais nudegimo traumos gydymo laikotarpiais siekiant padidinti raumenų jėgą, pagerinti fizinį pajėgumą, bendrą organizmo funkciją, liesąją kūno masę, ir neturi neigiamo poveikio hipermetaboliniam atsakui.

Raktažodžiai: nudegimų trauma, kineziterapija, pratimai, raumenų jėga, reabilitacija
Photobiological hydrogen as a renewable fuel
Authors: Jose Vidya
Published: February 2021

The huge global energy consumption has raised concerns over the depletion in readily available conventional energy resources. Besides, there are harmful atmospheric effects of fossil fuels and the qualms of future energy resources. The world hence is in dire need of new renewable energy sources that are cheap, non-polluting, environmentally friendly, and clean. This is the only way we can stop using fossil. Hydrogen is considered as an ideal fuel for the future because of its high energy content and its clean combustion to water. However, extensive technologies are required to introduce hydrogen as an alternative clean and cost-effective future fuel, which brings about the relevance of the exploitation of the microorganisms for large-scale renewable energy production. Reports of photobiological hydrogen production by oxygenic photosynthetic microbes, such as green algae and cyanobacteria and by anaerobic photosynthesis, are summarized in this paper, with a focus on the major obstacles that must be overcome by scientific and technical breakthroughs to make way for commercially feasible energy. The principle, progress, and prognosis of photobiological hydrogen as a renewable energy source are reviewed.
MODELING OF CAREER CHOICE BEHAVIORS IN INDONESIAN DENTISTRY STUDENTS
Authors: Caesarani Fianirazha Primesa , Astria Febby , Syakurah Rizma Adlia , Aulia Bertha , Siburian Reynold
Published: February 2021

The increasing number of dentists shows that this profession is one of the most popular career choices in Indonesia. The type of dentist professional development varies so that career planning is an important thing that has a big influence on one's future. The social-cognitive career theory (SCCT) perspective explains that there is a relationship between career self-efficacy, career outcome expectation, career intention and career exploration in the career selection process. By using SCCT, this study aimed to determine the career exploration-related behavior relationship, which consists of career self-efficacy, career outcome expectations, career intention and career exploration, in the career determination for dentistry students in Indonesia. This research is an observational analytic study of 505 samples of undergraduate and profession students of dentistry who have filled out an online questionnaire from March to June 2019. An online questionnaire consisting of a Career Decision Making Self-Efficacy-Short Form (CDMSE-SF), Career Decision Outcome Expectation (CDMOE), Career Exploration Planning or Intention Questionnaire (CEPI), Career Exploration Survey-Revised (CES-R), which has translated and validated. All models are analyzed using the maximum possible estimation of the AMOS application. This research showed that there was a significant relationship between having a career plan and father's job. This study concluded that self efficacy, outcome expectation, and career intention influence the career exploration of dentistry students significantly both directly and indirectly.
Envisioning the Veracity of Digital Ecosystem in Improvising Effective Pandemic Response
Authors: Bharti Aditya , Krishnan Supriya , Bharti Sudhanshu Kumar
Published: February 2021

The obfuscation and the kind of cover-up or delay in COVID-19 crisis response put the veracity of global healthcare settings at stake and appended a biological dimension to geopolitical tensions. The ineffectual surveillance systems of public health and social measures cause the swift viral transmission pace amid mounting death toll and necessitate for an effective, cohesive, and strategic response. The digital ecosystem can serve the purposes intended in a transparent and immutable manner. This article highlights the problems encountered by the global healthcare settings in responding to pandemic and throws light on how the global digital ecosystem can handle crisis by managing the landscape radically through transparent information sharing via Internet of things (IoT) with the data being utilized by artificial intelligence (AI) and blockchain technologies on a cross-disciplinary collaborative basis. It will help to develop and provide borderless solutions of public health via monitoring, surveillance, detection, and prevention as well as digi-tool-assisted repurposed treatment by the use of authentic and decentralized distributed database that makes all contributors (participating countries, United Nations Organizations, the world medical associations, and global media and publications) accountable, inviolable, and efficient to tackle healthcare processes. It will extricate a blanket ban on information sharing thereby bringing democracy and freedom.