bluuebunny/crossref_metadata_2025 huggingface dataset:
METAPHOR AND MYTH AS ELEMENTS OF ARTISTIC-LANGUAGE
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Panchenko V. I.
Published: February 2020

The article is devoted to analysis of the artistic culturestructure. Artistic culture has developed its main structural elements that provide a certain logic of artistic thinking and artistic creativity and which are the basis of any work of art. These structural elements – rhythm, intonation, metaphor, myth (as a way of action organizing, as a prototype of composition), archetypes and archetypal symbols – are the main artistic means that "work" in all types of art, while defining the specifics (due to their dominance) of the each one of them.
Visualization of moral contents in a fairy tale
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Rohozha M. M.
Published: February 2020

Contemporary culture is represented in the paper in the fairy tale optics in its ethical dimensions. Such prospects allow to ascertain ethical values which contemporaneity draws in archaic stratum of culture and generates basing on invariants of past. Using M. M. Bakhtin's ideas of great time of culture and outsideness, the author exposes a fairy tale as a phenomenon that once appeared in archaics but in every further cultural-historic period is able to represent its new facets what are unknown to all previous epochs. A fairy tale acts in therapeutic, orienting and educational functions since the time if its origins. Today a fairy tale has lost archaic horror tinge and obtained some romantic veil and moralistic color. These dimensions are reflected in an image of a hero. The paper points out the distinction between ethical and democratic heroes (the idea of M. E. Meletinsky). It is mentioned that content of an image of a democratic hero is better grasped by the N. Tec's concept a "dormant hero". It is a dormant hero whom contemporary culture comprehends most of all types of a fairy tale heroes. He leaves an impression that everybody can find oneself at his place. His heroic powers are ex- posed gradually. During the storytelling, it is turned out that he possesses definite virtues, personifies moral integrity. It is mentioned in the paper that today there are transformations in the comprehension what qualities are virtues. Qualities necessary for support of ancestors' cult as well as for keeping house were considered as virtues in archaic culture whereas contemporaneity represents in current fairy tale adaptations qualities clear for people today, such as valor, courage, resourcefulness, quick-wittedness. Virtues allow hero to negotiate obstacles, pass tests. Ethical pathos of a fairy tale is accumulated in victorious struggle against evil, for realization of justice, resumption of the lost equity. Ethical content of a fairy tale are visualized. At the basic level, visualization of good and evil is represented in immediate reality of beauty and ugliness. The second level of ethical content visualization is specified by imagination which allows audience to create images and visualize meanings in free flight of fancy. The third level is determined by proper ability of a fairy tale to use symbols. At that level, heroes are represented as symbols-keepers of cultural memory.
Semilinguisme
Authors: Kremnitz Georg
Published: February 2020

Le terme de semilinguisme n’est pas très estimé ni par les linguistes ni par les didacticiens. Or, le phénomène se montre bel et bien. L’article tente une approche à partir de quelques exemples pour ensuite suivre la genèse du terme et cerner les formes de semilinguisme. Une telle approche inductive espère arriver non seulement à une description mais aussi au vécu des semilingues.
The Distinctness Condition in SLI: More on the Specific Externalization Impairment
Authors: Lorenzo González Guillermo , Vares Elena
Published: February 2020

Este trabajo desarrolla la idea de que el módulo de externalización lingüística es un punto de afectación particularmente sensible en casos de Trastorno Específico del Lenguaje. A partir de una muestra de construcciones transitivas, así como de elaboraciones interrogativas y relativas de este mismo tipo, se explora la hipótesis de que los casos considerados pueden recibir una explicación común basada en un principio especialmente prominente del procedimiento de alineación del mencionado módulo: en concreto, el principio de Distintividad. Se concluye que los niños con Trastorno Específico del Lenguaje no son ajenos a este principio, aunque lo satisfacen mediante estrategias idiosincráticas, en comparación con las empleadas por los hablantes sin afectación.
Sobre el valor de la dialectometría en la delimitación de las distancias lingüísticas
Authors: Aurrekoetxea Olabarri Gotzon
Published: February 2020

Este trabajo constituye una reflexión sobre el aporte de la dialectometría a la delimitación de las distancias lingüísticas, centrándose exclusivamente en el análisis cuantitativo de la variación geolingüística. Después de un somero repaso sobre las contribuciones de la dialectología tradicional y la dialectología aglo­merativa, se analizan distintos aspectos que la dialectología cuantitativa ha proporcionado a esta disciplina: la isoglosa cuantitativa, la clasificación jerárquica de las hablas, la correlación entre la diferenciación lingüís­tica y la distancia geográfica, etc.
Review of THE STORY OF ZERO by T. Givón
Authors: Cornish Francis
Published: February 2020

Reseña de:T. Givón (2017): The Story of Zero, Amsterdam/Philadelphia: John Benjamins [414 pp.]. ISBN: 978-90-272-1239-9.
Reseña de ESTUDIU DE LA TRANSICIÓN LLINGÜÍSTICA NA ZONA EO-NAVIA, ASTURIES. ETLEN, dirigido por Ramón d’Andrés
Authors: Gargallo Gil José Enrique
Published: February 2020

Reseña de:Ramón d’Andrés Díaz (dir.), Fernando Álvarez‑Balbuena García, Xosé Miguel Suárez Fernández y Miguel Rodríguez Monteavaro (2017): Estudiu de la transi­ción llingüística na zona Eo-Navia, Asturies. ETLEN. Atles llingüísticu. Dialectográficu - Horiométricu - Dialectométricu, Uviéu: Trabe [1083 pp.]. ISBN: 978-84-8053-892-3.
Reseña de PALABRAS EN CONTEXTO. PRAGMÁTICA Y OTRAS TEORÍAS DEL SIGNIFICADO, de Graciela Reyes
Authors: Teso Martín Enrique del
Published: February 2020

Reseña de:Graciela Reyes (2018): Palabras en contexto. Pragmática y otras teorías del signifi­cado, Madrid: Arco/Libros [460 pp.]. ISBN: 978-84-7635-972-3.
Identidad etnosociolingüística y política lingüística. A propósito del Paraguay contemporáneo
Authors: Boyer Henri
Published: February 2020

En esta contribución me propongo analizar el papel de las representaciones etnosociolingüísticas en la dinámica actual de una configuración bi/plurilingüe, la del Paraguay, “pluricultural y bilingüe”, en la que la lengua mayoritaria (el guaraní) está en situación de minor(iz)ación y donde se está desarrollando una acción glotopolítica oficial con el objetivo de permitir que la lengua minorizada recupere o conquiste las funciones sociales normales de una lengua histórica, como es el caso del castellano en el mismo país. Es obvio que si bien la importancia de las circunstancias demolingüísticas no se puede negar, lo que sí se tiene que valorar es la importancia de los imaginarios sociolingüísticos en la evolución positiva o negativa del conflicto que atraviesa toda la comunidad lingüística, según el tipo de política lingüística institucional que se ha (o no se ha) implementado. Se trata al fin y al cabo del éxito o del fracaso de la normalización lingüística y del impacto en el proceso glotopolítico de la lealtad lingüística, actitud ligada a representaciones etnosociolingüísticas identitarias.
Accounting for Uncertainties of Magnitude- and Site-Related Parameters on Neural Network-Computed Ground-Motion Prediction Equations
Authors: Wang Zhiyi , Zentner Irmela , Zio Enrico
Published: February 2020

Ground-motion prediction equations (GMPEs) are used to express seismic intensity measures as a function of source-, path-, and site-related parameters. Functional models are still widely used for their computation. Fully data-driven approaches have been recently proposed based on artificial neural networks (ANNs). However, the estimation errors of the predictor parameters (e.g., the magnitude and VS30) are generally not accounted for in the development of GMPEs. In the present study, the uncertainty in the magnitude- and site-related parameters is considered in the establishment of GMPEs by ANNs. For this, an algorithm is proposed based on the generalized least-squares principle applied to ANNs training. A simulated database is used to validate the approach and to demonstrate the effect of the input parameter uncertainties on the GMPEs. Finally, the proposed model is applied to the Reference database for seismic ground motion in Europe (RESORCE) database. Results show that the consideration of uncertainty in the magnitude- and site-related parameters can reduce the total GMPE uncertainties by 4%–16%, whereas the median predictions remain similar.
A New Technique to Calculate Earthquake Stress Transfer and to Probe the Physics of Aftershocks
Authors: Segou Margarita , Parsons Tom
Published: February 2020

Coseismic stress changes have been the primary physical principle used to explain aftershocks and triggered earthquakes. However, this method does not adequately forecast earthquake rates and diverse rupture populations when subjected to formal testing. We show that earthquake forecasts can be impaired by assumptions made in physics-based models such as the existence of hypothetical optimal faults and regional scale invariability of the stress field. We compare calculations made under these assumptions along with different realizations of a new conceptual triggering model that features a complete assay of all possible ruptures. In this concept, there always exists a set of theoretical planes that has positive failure stress conditions under a combination of background and coseismic static stress change. In the Earth, all of these theoretical planes may not exist, and if they do, they may not be ready to fail. Thus, the actual aftershock plane may not correspond to the plane with the maximum stress change value. This is consistent with observations that mainshocks commonly activate faults with exotic orientations and rakes. Our testing ground is the M 7.2, 2010 El Mayor–Cucapah earthquake sequence that activated multiple diverse fault populations across the United States–Mexico border in California and Baja California. We carry out a retrospective test involving 748 M≥3.0 triggered earthquakes that occurred during a 3 yr period after the mainshock. We find that a probabilistic expression of possible aftershock planes constrained by premainshock rupture patterns is strongly favored (89% of aftershocks consistent with static stress triggering) versus an optimal fault implementation (35% consistent). Results show that coseismic stress change magnitudes do not necessarily control earthquake triggering, instead we find that the summed background stress and coseismic stress change promotes diverse ruptures. Our model can thus explain earthquake triggering in regions where optimal plane mapping shows coseismic stress reduction.
Telaah ulang wacana haid dan istiḥāḍah pada akseptor keluarga berencana
Authors: Setiawan Wahyu , Siradjuddin Azmi , Liberty Liberty
Published: February 2020

Penetapan hukum darah pervaginam dalam Islam secara umum menggunakan paradigma yang dapat disebut haid-cum-istiḥāḍah. Paradigma ini bertitik tolak pada identifkasi darah haid terlebih dahulu dengan melihat batas minimal, batas maksimal, atau berdasarkan karakter darah. Apabila tidak memenuhi syarat yang telah ditetapkan madhhab fiqh, maka darah disebut sebagai istiḥāḍah. Paradigma ini menjadi rancu ketika dihadapkan dengan ketidakteraturan menstruasi yang dialami akseptor KB hormonal. Darah pervaginam yang terjadi tidak dapat disebut sebagai haid baik menurut medis maupun literatur fiqh. Artikel ini menawarkan paradigma alternatif yang disebut istiḥāḍah-cum-haid. Sebuah paradigma yang merupakan hasil integrasi tiga kutub: interpretasi turāth, keilmuan medis, dan pengalaman empiris akseptor KB hormonal. Dialog ketiga kutub tersebut dibingkai dengan kerangka berpikir Loay Safi yang disebut Unified Approach to Textual and Contextual Analysis. Data penelitian ini dikumpulkan melalui kajian kitab-kitab fiqh perbandingan dan wawancara dengan 70 akseptor, 1 dokter spesialis kandungan, 5 bidan, dan 4 praktisi akademik kesehatan. Paradigma alternatif sebagai hasil penelitian ini menyatakan bahwa darah pervaginam pada akseptor langsung ditetapkan sebagai istiḥāḍah. Tahap berikutnya berupa penetapan hari-hari haid bagi akseptor KB berdasar fiqh madhhab terkait ketentuan hukum mustaḥāḍah. The legal inference of vaginal blood in Islam generally adopts the paradigm called haid-cum-istiḥāḍah. The paradigm starts with the identification of menstrual blood by looking at minimum limit, maximum limit, or by blood characters. When the blood fails the requirements established by madhhab fiqh, it turns to the so-termed istiḥāḍah. The paradigm tends to be confusing when confronted with menstrual irregularities that happened on hormonal acceptors. The vaginal blood could not be categorized as menstrual by medical or fiqh literatures. This article offers an alternative paradigm called istiḥāḍah-cum-haid wich is built upon three building blocks namely: turāth interpretation, medical considerations, and empirical experiences of hormonal acceptors. These three building blocks were underpinned by Loay Safi’s thought called Unified Approach to Textual and Contextual Analysis. The data of this research were collected through studies on comparative fiqh literatures and interviews with 70 acceptors, 1 obstetrician-gynecologist, 5 midwifes, and 4 academicians in the field of medication. This alternative paradigm urges that vaginal blood acceptors treated as istiḥāḍah. Next to istiḥāḍah identification, is the establishment of menstruation days for acceptors based on fiqh madhhab related to mustaḥāḍah rules.
Estrategia FIGO para la prevención del aborto inseguro. Experiencia en Colombia
Authors: Gómez-Sánchez Pío Iván , Urquijo-Velásquez Lenis Enrique , Villarreal Cristina
Published: February 2020

Objetivo: analizar la situación del aborto inseguro en Colombia para establecer: consecuencias, factores determinantes y calidad de la atención e identificar los puntos susceptibles de intervención, para elaborar un plan de acción tendiente a reducir los embarazos no deseados, abortos provocados y sus consecuencias.Materiales y métodos: estudio cualitativo con un componente de revisión de material bibliográfico y otro de consenso de expertos. Se llevó a cabo en dos fases. En la fase 1, de análisis situacional, se recolectó información mediante el formato elaborado por el grupo de trabajo de FIGO (Federación Internacional de Ginecología y Obstetricia). En la fase 2, de elaboración del plan de acción utilizando un marco lógico, se reunieron los representantes de OPS (Organización Panamericana de la Salud), UNFPA (Fondo de Población de las Naciones Unidas), filiales de IPPF (Federación Internacional de Planificación Familiar), ONG locales y agencias del gobierno.Resultados: el análisis situacional se resume en tres ejes: embarazo no deseado, intervenciones para su prevención y aborto. En el plan de acción se definieron cuatro objetivos específicos: mejorar el acceso a los servicios de salud sexual y reproductiva; facilitar el acceso a la interrupción voluntaria del embarazo acorde con la Sentencia C-355 de 2006; promover el acceso al misoprostol para usos ginecoobstétricos; y mejorar la información sobre tasas y complicaciones asociadas al aborto inseguro.Conclusión: a pesar del avance en Colombia con la Sentencia C-355 de 2006, aún persisten grandes retos, tales como reglamentar opciones de fácil acceso al servicio de interrupción voluntaria del embarazo para mujeres víctimas del conflicto armado, protocolos de investigación al interior de los tribunales de ética médica para los asuntos relacionados con objeción de conciencia, clarificar la autonomía y capacidad de menores de catorce años.
Comparison of adductor canal block and local infiltration analgesia techniques for postoperative analgesia in gonarthrosis patients receiving a total knee prosthesis
Authors: BAŞKAN Semih , OKEN Fuad , KILCI Oya , DILEK Kevser , TIRIN Hakan , YILDIRIM Ozgur , INCI Fatih , ORNEK Dilsen
Published: February 2020

Aim: Total knee arthroplasty (TKA) is a major orthopaedic surgery, and patients experience severe postoperative pain. Local infiltration anaesthesia and/or peripheral nerve blocks are often used for analgesia after TKA. The aim of this study was to compare the analgesic efficacy of the local infiltration anaesthesia and adductor canal block (ACB) techniques in the first postoperative 24 hours after TKA.Material and Methods: Sixty patients of both sexes who were aged 40-80 years, in the ASA I-III group and undergoing TKA were included in this study after approval of the local ethics committee. Spinal anaesthesia was achieved with 15 mg 0.5% heavy bupivacaine in all patients. In Group I, nerve blocks were applied under ultrasonography with a 20 mL 0.25% bupivacaine. In Group II, a 60 ml cocktail was injected into the periarticular area and subcutaneous tissue. Postoperative pain was evaluated at 0, 1, 2, 8, 12, and 24 hours with a visual analogue scale (VAS). When the VAS score was >4 or the patient reported a need for pain relief, intravenous analgesics were administered, and the analgesia requirement time was recorded. Statistical analysis was performed with IBM SPSS 23.0 software. A value of p<0.05 was accepted as significant.Results: No statistically significant differences were determined between groups with respect to the demographic data or VAS values (p>0.05). All patients in Group I and 28 patients in Group II required additional analgesia at 10.0±4.9 hours and 8.7±6.02 hours. These differences were not statistically significant (p>0.05).Conclusion: The study showed that both methods provided effective analgesia and can be used for a multimodal analgesia method postoperatively in the first 24 hours after TKA operations.
Disjunctive Multiple-Conclusion Consequence Relations
Authors: Nowak Marek
Published: February 2020

The concept of multiple-conclusion consequence relation from [8] and [7] is considered. The closure operation C assigning to any binary relation r (dened on the power set of a set of all formulas of a given language) the least multiple-conclusion consequence relation containing r, is dened on the grounds of a natural Galois connection. It is shown that the very closure C is an isomorphism from the power set algebra of a simple binary relation to the Boolean algebra of all multiple-conclusion consequence relations.
FEATURES OF THE METABOLIC COMPOSITION OF SPERMAL PLASMA IN DIFFERENT MORPHOFUNCTIONAL PATHOLOGIES OF THE EJACULATE
Authors: Gusyakova O. A. , Murskiy S. I. , Tukmanov G. V. , Komarova M. V.
Published: February 2020

As part of the work, an assessment was made of the state of the metabolic characteristics of sperm plasma in various morpho-functional ejaculate pathologies. Physico-chemical, metabolic and morphological parameters of the ejaculate were evaluated. The diagnostic protocol included a standard sperm analysis with classification of ejaculate parameters and determination of biochemical parameters of sperm plasma on an automatic biochemical analyzer. The study of the qualitative and quantitative characteristics of metabolic parameters. The total number of surveyed was XX people. After studying the morphological features of the cell composition, the obtained samples were divided into four groups: samples with normospermia, samples with oligoasthenoteratozoospermia, samples with azoospermia, and samples with cryptozoospermia. In each group, the parameters of protein, carbohydrate, lipid and mineral metabolism were studied. As a result, it was found that with the progression of pathology, the catabolic mechanism of energy consumption begins to prevail, due to a decrease in the concentration in the sperm plasma of protein components, transaminases, as well as the growth of non-protein nitrogenous inclusions. It is noted that the growth of glucose, despite the inhibition of transmembrane routes of intake by reducing the concentration of alkaline phosphatase and lipid-transport systems, is associated with the forced inclusion of insulating mechanisms for the penetration of glucose into the sperm plasma from the blood through the hemato-sperm barrier. At the same time, an increase in the content of lipids in the sperm plasma, as well as the growth of creatinine in the initial stages of the development of pathology, can be characterized by a compensatory response aimed at maintaining the viability of minimal amounts of spermatozoa. Well, the disorder of mineral metabolism in general characterizes the violation of metabolic processes in all forms of ejaculate pathology. Identified features of the metabolism in the sperm plasma may further allow to identify more informative laboratory markers of male infertility.
STUDY OF HEPSIDIN AND OTHER REGULATORY PROTEINS IN DIFFERENT PERIODS OF PREGNANCY
Authors: Shahverdiyeva Ilaha Jamshid
Published: February 2020

This research paper presents the results of a study of some indicators of iron metabolism in anaemia in pregnant women. The venous blood of 39 pregnant women with anaemia was examined. Serum ferritin, ferroportin and hepcidin were investigated for this purpose. The comparison group consisted of 19 pregnant women without anaemia. The haemoglobin concentration was measured by using «Mythic-18» haematological autoanalyzer. The concentrations of hepcidin and ferroportin were determined by using «Cloud-Clone Corp.» (USA), and ferritin concentrations were determined by using «Pishtaz teb» (Iran) reagents through enzyme-linked immunosorbent assay (ELISA) method. The study revealed a significant decrease in the level of ferritin, hepcidin and a significant increase in ferroportin level. A comprehensive definition of various indicators of iron metabolism provides important information not only for understanding the pathogenesis of iron deficiency anaemia in pregnant women but also for early diagnosis of the disease and the appointment of the correct treatment.
NEW LABORATORY PARAMETERS IN THE DIAGNOSIS OF ACUTE MESENTERIC ISCHEMIA
Authors: Artamonova Z. A. , Namokonov E. V.
Published: February 2020

Lack of clear clinical and laboratory picture of subjective evaluation of bowel viability, the progression of bowel necrosis in the postoperative period with acute mesenteric ischemia (АМI) contributes to the high mortality rate. Earlier experiments we proved that gut necrosis leads to changes in the subpopulation structure of blood lymphocytes. This prompted us to determine the clinical significance of the subpopulation structure of venous blood lymphocytes in patients with acute mesenteric ischemia. The paper is based on a retrospective analysis of the results of a controlled clinical and immunological examination of 18 patients aged 62 to 78 years (control group and a group of АМI). Evaluation lymphocyte subpopulation structure was performed by the standard method of direct immunofluorescence staining of whole blood. The obtained data were processed with nonparametric statistical methods. Study of lymphocyte subpopulation structure in patients with АМI patients showed a decrease in the absolute and relative number of CD8, CD4, B, NK cells on the indicators in the control group. Ischemia and necrosis of the intestinal mucosa accompanied by a massive translocation of intestinal microflora through the impaired intestinal barrier along with the migration of lymphocytes into the lesion and death, which is manifested in a decrease in the number of lymphocytes of the peripheral blood. Comprehensive assessment of venous blood lymphocyte subpopulation structure can be used as an additional diagnostic criterion necrotic step АМI, serve as criteria for selection of patients for immunotherapy.
HOMOARGININE LEVEL AND METHIONINE-HOMOCYSTEINE BALANCE IN PATIENTS WITH ISCHEMIC HEART DISEASE
Authors: Zhloba A. A. , Subbotina T. F. , Molchan N. S. , Polushin Yu. S.
Published: February 2020

The level of homoarginine (hArg) in terms of prognostic significance may exceed the natriuretic peptides and other well-known markers according to the latest data about the progression of cardiovascular diseases. The lack of data on the association of hArg levels with levels of other metabolites makes it difficult to understand its role in the pathogenesis of cardiovascular diseases. Relationships of hArg and other amino acids, including methionine (Met) and total homocysteine (tHcy), and their ratio in patients with ischemic heart disease were evaluated. The study included 74 patients with coronary heart disease (57 men and 17 women) aged 62 (57 - 67) years before coronary artery bypass surgery and 27 healthy people of similar age. In patients, the level of hArg was almost 2 times lower (p <0.05) than in healthy individuals and rates lower than 1.4 μM were in half of them. The statistically significant decrease (p = 0.0025) of the Met/tHcy ratio corresponded to a decrease in the level of hArg. This ratio did not correlate with glucose level or body mass index. Less statistical significance of hArg correlation with levels of Met or tHcy separately was observed. In the subgroup of patients with hAarg level above 2.1 μM, a lower incidence of myocardial infarction was noted. Thus, a low hArg level is associated with impaired metabolism of sulfur-containing amino acids involved in transmethylation reactions, in patients with ischemic heart disease. The Met/tHcy ratio, closely correlating with the level of hArg, apparently reveals a link between the reactions of creatine formation and transmethylation, highlighting a cohort of patients with the most profound and dangerous changes in tissue metabolism.
DIAGNOSTIC IMMINOARRAY ASSAY FOR CHARACTERIZATION OF IMMUNOGLOBULIN IGG AND IGM LEVEL IN SYPHILIS PATIENTS SERUM TOWARDS 12 RECOMBINANT ANTIGENS OF T. PALLIDUM BEFORE AND AFTER THE THERAPY
Authors: Runina A. V. , Shpilevaya M. V. , Filippova M. A. , Katunin G. L. , Kubanov A. A.
Published: February 2020

The aim of the study was to characterize the dynamics of immunoglobulin IgG and IgM level in syphilis patients serum at different stages of the disease before and after the therapy towards 12 diagnostic antigens of T. pallidum in an microarray assay and to evaluate these data as possible prognostic markers. The dynamics of immunoglobulin IgG and IgM level was measured in the reaction of indirect immunofluorescence using microarray and compared to the results of non-treponemal RPR test and treponemal tests as EIA and reaction of passive hemagglutination. In microarray assay diagnostically high level of IgM in patients with primary, secondary and early latent and late latent syphilis decreased dramatically to zero after the successful therapy. Continuously high level of IgM after the therapy proposes the persistence of infection agents in the organism and points out the need of additional antimicrobial treatment. In most of the cases anti-treponemal IgG level also declined after the successful therapy and this confirms the appropriate treatment. The results of microarray assay coincide with the results of other mentioned laboratory tests for syphilis diagnostics. Microarray assay with the recombinant T. pallidum antigens gives the perspective for creating methods with wider spectrum of diagnostic and therapy control options using the IgM immunoglobulin level as a marker for successful syphilis treatment.
POSSIBILITY OF SEROLOGICAL VERIFICATION OF SIBERIAN TICK TYPHUS WITH THE TEST SYSTEM FOR IDENTIFICATION OF RICKETTSIA CONORII ANTIBODIES
Authors: Rudakov N. V. , Shtrek S. V. , Blokh A. I. , Penjevskaya N. A. , Shchuchinova L. D.
Published: February 2020

The real epidemiological impact of Spotted Fever Group rickettsioses including Siberian tick-borne typhus (STT) in Russia is not sufficiently studied. One of the reasons is the actual absence of either certified domestic diagnostic kits or the evidence for using foreign test kits for laboratory verification of this group of tick-borne infections in medical practice. Objective of our study was to study the diagnostic accuracy of the ELISA test system based on Rickettsia conorii antigens for serological verification of STT. The ROC analysis was performed and operational characteristics (sensitivity, specificity, accuracy, likelihood ratio of positive and negative results) of the STT serological verification test to identify IgM to rickettsia at different times from the onset of the disease using a test system to detect antibodies to Rickettsia conorii were calculated based on the results of a survey of two groups of patients comparable by gender and age (34 patients with pathognomonic signs of STT and 76 clinically healthy people). It was found that the detection of IgM antibodies to rickettsia using the Rickettsia conorii IgM/IgG ELISA test system (Vircell) allows the disease to be verified 10-14 days after the onset of clinical symptoms in 72% (56-88%) of STT patients. We recommend the interpretation of results of the test system “Rickettsia conorii ELISA IgM/IgG” for serological verification of STT which differ from the manufacturer’s recommendations regarding verification of Mediterranean fever caused by R. conorii in the following way: the diagnosis of STT should be considered laboratory confirmed when the index of IgM antibodies (IAT) exceeds 8.0; if the IAT is less than 5.0 then a repeated examination of the patient after 10-14 days will be necessary; if the IAT is in the range of 5.0-8.0 then the sample should be re-examined and / or the patient should be examined after 10-14 days. The use of the test system “Rickettsia conorii ELISA IgM / IgG” is promising for laboratory diagnosis and seroepidemiological studies of Spotted Fever Group rickettsioses in Russia.
DEVELOPMENT AND ASSESSMENT OF A REAGENT KIT FOR RNA DETECTION OF CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS WITH USING REVERSE TRANSCRIPTION LOOP-MEDIATED ISOTHERMAL AMPLIFICATION METHOD
Authors: Ternovoi V. A. , Kononova Yu. V. , Zaykovskaya A. V. , Chub E. V. , Volynkina A. S. , Mikryukova T. P. , Kotenev E. S. , Pyankov O. V. , Sementsova A. O. , Loktev V. B.
Published: February 2020

This study presents the results of laboratory trials of the reagent kit for the rapid detection of RNA of the Crimean-Congo hemorrhagic fever virus (CCHFV) using loop-mediated isothermal amplification with reverse transcription (RT-LAMP). The developed RT-LAMP reagent kit was used to detect the CCHFV and showed a sensitivity of 103 GE/ml of viral RNA, which is sufficient for detection of the CCHFV in the early stage of human infections. The kit showed high specificity and no cross-reactivity with viral panel from the State collection of viruses of the FBRI SRC VB «Vector» (arboviruses and hemorrhagic fever viruses). Laboratory trials of the RT-LAMP kit are showed a high analytical and diagnostic sensitivity and specificity for RNA detection of the CCHFV and high speed of the analysis (60-70 min with sample preparation) compared to real-time PCR. Approbation of the kit field version has showed the possibility of setting the RT-LAMP reaction and viral RNA detection without the using of analytical equipments.
STORAGE, ACCESS AND PROTECTION OF FULL GENOME SEQUENCING DATA IN RUSSIA AND FOREIGN COUNTRIES: PRACTICAL ASPECT
Authors: Suranova T. G. , Suvorov G. N.
Published: February 2020

The relevance of the chosen topic is due to the need to resolve legal problems in the field of observance of human and civil rights and freedoms when storing, accessing and protecting full genome sequencing data. The purpose of this study is the formation of conceptual criteria on the basis of which a new model of regulatory regulation of this sphere of public relations will be built. To achieve this goal, the tasks of studying the regulatory legal acts in force in Russia and a number of foreign countries were solved. General scientific, private-scientific and special methods of scientific knowledge (system-structural, formal-legal) were used. In order to formulate conceptual criteria of practical importance for storing access and protecting genome-wide sequencing data in Russia and foreign countries, it was proposed to develop clarifying characteristics or gradation of human and civil rights and freedoms in the context of realization of public state interests. It is also necessary to unify the content of the conceptual apparatus of normative acts taking into account the peculiarities of genetic information, work out the procedure for accessing data, and provide for a system of its depersonification. For the first time, the authors substantiate the need to transform the content of the human rights declared by the state to life, freedom, personal and family secrets, and others with the development of new technologies in the field of DNA scanning. The basic criteria that are of practical importance for the storage, access and protection of genome-wide sequencing data indicate the need to improve normative concepts, establish categories of persons with the right to access such data, normatively fix the conditions for observing an anonymous survey, and also refuse to get acquainted with the results , to develop mechanisms for the depersonification of the obtained genetic information).
Insufficient evidence intraperitoneal fluid is equivalent or superior to intravenous fluid therapy in dehydrated calves
Authors: Gunn Allan John , Crawshaw Timothy , Brookes Victoria
Published: February 2020

PICO question
In calves <14 days old which are moderately to severely dehydrated (5–9%) or acidaemic (base excess -5 to -15 mM), does intraperitoneal fluid therapy result in comparable or superior clinical improvement when compared to intravenous fluid therapy?
Clinical bottom line
Only two studies were identified, and these studies provide insufficient evidence that intraperitoneal (IP) fluid is comparable to, or provides superior clinical improvement, when compared to intravenous (IV) fluid therapy in moderately to severely dehydrated (5–9 %) or acidaemic calves (base excess -5 to -15 mM) aged < 14 days of age. Given the lower expected non-clinical costs of IP fluids relative to IV fluids (labour and time) we suggest further studies are required to investigate the safety and clinical benefits of IP fluid administration in calves for this purpose.
Farklı IBA (İndol-3-Bütirik Asit) Dozları ve Köklendirme Ortamlarının Bazı Tıbbi Bitkilerin Köklenmesi Üzerine Etkileri
Authors: İZGİ Mehmet Necat
Published: February 2020

Bu çalışma; yağ gülü (Rosa damascena Mill.), kadıntuzluğu (Berberis thunbergii DC.), biberiye (Rosmarinus officinalisL.) ve lavanta (Lavandula angustifolia Mill.) bitkilerine ait çeliklerde, farklı köklendirme ortamları [torf, perlit, torf-perlit(1:1) ve kokopit] ve indol-3-bütirik asit (IBA) dozlarının (0, 1000, 2000, 3000, 4000, 5000 ppm) köklenmeye etkilerinisaptamak amacıyla yapılmıştır. Çelikler, sera ortamında farklı IBA çözeltilerine maruz tutularak dört farklı ortamda dikimleriyapılmıştır. Yaklaşık 80 gün köklendirmeye bırakılan çeliklerde köklenme oranları, kök uzunlukları ve kök sayılarıbelirlenmiştir. Araştırma sonucunda, köklendirme ortamları ve farklı dozlardaki IBA uygulamalarının yağ gülü, kadıntuzluğu,biberiye ve lavanta çeliklerinde köklenmeye etkisi anlamlı bulunmuştur. Yağ gülü, kadıntuzluğu, biberiye ve lavantabitkilerinde en yüksek köklenme oranları sırasıyla % 95.00, % 81.67, % 88.33 ve % 82.50; kök sayıları sırasıyla 19.28, 13.44,26.12 ve 17.38 adet bitki-1 ve kök uzunlukları sırasıyla 18.89, 14.32, 25.58 ve 17.26 cm ile perlit köklendirme ortamında ve4000-5000 ppm IBA çözeltisinde olduğu tespit edilmiştir. Bitki çeliklerinin köklendirme ortamı olarak perlit ortamından, IBAdozu olarak ise adventif köklenmeyi teşvik eden 4000 ppm uygulamasından en iyi sonuçlar alınmıştır.
Urgensi Pengaturan Suap Di Sektor Swasta Sebagai Tindak Pidana Korupsi Di Indonesia
Authors: Cahyana Fariz
Published: February 2020

Suap di sektor swasta dipandang sudah mendesak untuk segera diatur dalam perundang-undangan. Salah satu pertimbangan karena suap tidak hanya memberi efek pada hubungan antar sektor swasta, tetapi juga memberi dampak pada masyarakat, meskipun tidak ada kerugian secara langsung. Tindakan suap mengganggu jalannya aktivitas pasar dengan cara bersaing secara tidak sehat dan merusak persaingan yang adil. Dengan keberadaan aturan mengenai tindak pidana suap dapat membantu untuk melindungi integritas dan kejujuran dalam aktivitas ekonomi, keuangan, atau komersial. Metode penelitian yang digunakan dalam penelitian ini adalah statute approach dan conseptual approach. Adapun yang akan dibahas dalam penelitian ini adalah makna suap di sektor swasta berdasarkan UNCAC dan peraturan perundangundangan di Indonesia. Penelitian ini juga membahas dan menganalisis beberapa kasus suap yang terjadi baik di Indonesia maupun di luar Indonesia. Dari hasil penelitian ini diketahui bahwa penegakan hukum suap swasta di Indonesia belum berjalan secara efektif. Apabila hal tersebut dibiarkan maka akan terus menerus terjadi kasus-kasus suap di sektor swasta yang tidak hanya merugikan masyarakat tetapi secara tidak langsung juga berdampak pada Negara.
Tenaga Kerja Asing Yang Berhenti Sebelum Masa Kerja Berakhir
Authors: Cahyawati Giovanni Dinda
Published: February 2020

Pada asasnya orang asing yang berada di Indonesia dapat membawa keuntungan bagi negara, di samping itu setiap warga negara asing yang beriktikad baik tinggal di Indonesia, mendapatkan hak untuk dilindungi dan diberikan jaminan keamanan yang meliputi jiwa, harta benda, dan usahanya. WNA berhak mendapatkan pekerjaan di Indonesia, tetapi terdapat kualifikasi agar dengan adanya WNA sebagai Tenaga Kerja Asing (Selanjutnya disebut TKA) yang dipekerjakan oleh pemberi kerja wajib memenuhi persyaratan sesuai dalam Pasal 5 Peraturan Menteri Ketenagakerjaan Nomor 10 Tahun 2018 tentang Tata Cara Penggunaan Tenaga Kerja Asing (Selanjutnya disebut Permenaker Nomor 10 Tahun 2018). TKA yang bekerja di Indonesia sama halnya dengan pekerja asli Indonesia, mereka terikat hukum yang berlaku di Indonesia. Antara TKA dan perusahaan terikat kontrak pribadi, yang mana kontrak tersebut sama seperti kontrak antara pekerja asli Indonesia dengan perusahan, sehingga apabila salah satu ada yang wanprestasi maka dikenakan hukuman yang berlaku di Indonesia. TKA yang melanggar kontrak dengan mengundurkan diri sebelum masa kerja berakhir, harus dikenakan ganti kerugian sebagai bentuk tanggungjawabnya.
Tindak Pidana Korupsi Dalam Pemberian Dana Hibah
Authors: Pradana Haidi Anshar
Published: February 2020

Hibah dalam Peraturan perundangan-undangan di Indonesia terbagi menjadi dua konsep yaitu hibah dalam hukum privat dan hibah dalam hukum publik. Hibah dalam hukum privat merupakan pemberian benda berharga secara cuma-cuma dari seseorang yang masih hidup kepada seseorang yang masih hidup pula, sedangkan hibah yang diatur dalam hukum publik adalah pemberian dengan pengalihan hak atas sesuatu dari pemerintah atau pihak lain kepada pemerintah daerah atau sebaliknya yang secara spesifik telah ditetapkan peruntukkannya dan dilakukan melalui perjanjian. Tujuan dari hibah itu sendiri adalah sarana bagi Pemerintah untuk meningkatkan kesejahteraan masyarakat. Namun pada pelaksanaannya, seringkali pemberian hibah tersebut disalahgunakan yang menyebabkan terjadinya tindak pidana korupsi. Salah satu bentuk penyalahgunaan hibah adalah adanya orang yang memperdagangkan pengaruh yang tidak baik (broker). Berdasarkan laporan Forum Indonesia Untuk Transparansi Anggaran (FITRA) bahwa praktik pemberian hibah ini sangat rawan dan berpotensi merugikan keuangan daerah. Metode penelitian yang digunakan dalam penelitian ini adalah statute approach, conseptual approach, dan case approach. Adapun yang akan dibahas dalam penelitian ini adalah konsep mengenai hibah baik itu dalam hukum privat dan hukum publik. Penelitian ini juga membahas bagaimana pertanggungjawaban pidana bagi pelaku tindak pidana korupsi dalam pemberian dana hibah. Dari hasil penelitian ini diketahui letak persamaan dan perbedaan dari konsep hibah baik itu dalam hukum privat maupun hukum publik. Selain itu, dalam penelitian ini diketahui pula bahwa pelaku yang terbukti menyalahgunakan dana hibah dapat dimintai pertanggungjawaban pidana sebagaimana yang diatur dalam Undang-undang tindak pidana korupsi.
Restorasi Kelembagaan melalui Integrated Society Institution System sebagai Upaya Menuju Kota Ramah HAM di Kota Malang
Authors: Yusro Mochammad Abizar , Hilmy Muhammad Irfan , Azmi Rama Halim Nur
Published: February 2020

Pasal 28B ayat (2) Undang-Undang Dasar Negara Republik Indonesia memanifestasikan bahwa anak sebagai kelompok rentan telah diakomodasi hak fundamentalnya di dalam konstitusi. Hal ini juga selaras dengan Undang-Undang Nomor 23 Tahun 2003 Tentang Perlindungan Anak yang sangat komprehensif mengatur tentang tata cara perlindungan anak hingga pemidanaan terhadap orang yang menciderai hak-hak anak sebagai wujud konsekuensi logis Indonesia yang telah menandatangani Covention the right of Child (Konvensi Tentang Hak Anak) yang disahkan melalui Keppres Republik Indonesia Tahun 1996. Akan tetapi menurut data dari Kementrian Koordinator Bidang Kesejahteraan Rakyat dari tahun 2014 hingga tahun 2017 tercatat sebanyak 21.869.797 kasus kekerasan seksual terhadap anak, yang tersebar di 34 provinsi, dan 179 kabupaten dan kota. Sebesar 42-58% dari pelanggaran hak anak itu, merupakan kejahatan seksual terhadap anak. Dan pada tahun 2019 KPAI menerima 1.192 laporan kekerasan, termasuk kekerasan fisik, psikologis maupun seksual. Sehingga menjadi suatu refleksi terhadap bangsa ini bahwa terdapat urgensi untuk melindungi hak-hak anak terutama untuk terhindar dalam kejahatan dan kekerasan seksual. Oleh karena itu, diperlukan adanya suatu mekanisme optimasi penegakan hukum dan rehabilitasi yang terintegrasi terhadap korban kekerasan seksual anak sebagai upaya perlindungan hak anak sekaligus menuju kota ramah Hak Asasi Manusia (HAM). Penelitian ini menggunakan pendekatan perundang-undangan, konseptual, dan studi kasus. Kesimpulannya adalah bahwa problematika perlindungan hak asasi manusia di daerah terutama Kota Malang menjadi suatu keniscayaan. Sehingga dalam rangka pemenuhan hal tersebut penulis memberikan inovasi yang bernama integrated society institution system. Kata Kunci:
Optimalisasi Peran Pemerintah Daerah: Solusi Discriminatory Housing Practices Terhadap Mahasiswa Pendatang Papua di Kabupaten Sleman
Authors: Putri Pricillia , Naila Ridha , Adhi Nugroho
Published: February 2020

Diskriminasi rasial yang terjadi pada mahasiswa pendatang dari Papua merupakan fenomena yang pada dasarnya tidak diperbolehkan untuk alasan apa pun yang dalam penelitian ini mengarah pada hilangnya hak untuk mendapatkan tempat tinggal (kos). Larangan mengenai diskriminasi rasial sebenarnya sudah termaktub dalam UndangUndang Dasar Negara Republik Indonesia Tahun 1945 (UUD 1945) khususnya Pasal 27 ayat (1), Pasal 28D ayat (1), dan Pasal 28I ayat (1) dan ayat (2). Namun, seringkali peraturan teknis dan tata kelola lembaga menemui jalan buntu dalam penindakan dan penanganan diskriminasi rasial. Adapun jenis penelitian yang dilakukan adalah penelitian hukum normatif yaitu penelitian yang berfokus pada bentuk positif norma dan peraturan hukum. Jenis data yang digunakan meliputi data primer berupa wawancara dan data sekunder. Lebih lanjut, penelitian ini akan membahas mengenai perlakuan diskriminatif untuk mahasiswa pendatang dari Papua berupa penolakan dalam kaitannya memperoleh kos-kosan, serta rekomendasi kebijakan yang diharapkan implementatif untuk mengatasi problematika tersebut.
PEMILIHAN MODA TRANSPORTASI SETELAH ADANYA KERETA COMUTER LINE (STUDI DAERAH PENYANGGA JAKARTA)
Authors: Munandar Aris
Published: February 2020

ABSTRACT

This study aimed to get a general idea about the selection of transportation modes resident in the buffer after the comuter line. The research time of the month from May to July 2014. The population in this study were all passengers in the Depok , Bekasi , Tangerang stasiun . The sampling technique was done by purposive sampling, passengers who choose rail transportation mode before applying commuterline using other modes . Each station 30 so that the total of 90 respondents. Characteristic of the youngest respondents aged 16 years and the oldest 50 years with an average of 26.9 years . The Based work on non-civil . Based on the level of respondents at most high school education. Based on user characteristics of respondents have either two-wheel motor vehicles and driving licence (SIM) equipped . Motor vehicles used by the respondent as a feeder . Average of the marital status of unmarried respondents . For those who are married earned income respondents said inadequate needs . Inadequate income would find it difficult to save . Respondents largely did not participate in the community commuter line . Based on the characteristics of the movement of the majority of respondents travel destinations for work purposes . Based on the characteristics mode facility, respondents to travel departing in the morning , come home in the afternoon rush hour . Respondents went on a trip with other existing modes . Respondents do not make the shift from the other trains . Travel time required respondents to make every trip is in accordance with her wishes . For short trips ( 10 stasion ) takes 50 minutes . Resonden not rest / sleep when the train . The cost for short trips ( 10 stations ) of Rp 3,000 , including low cost . Respondents were more likely to use multi- trip cards than single trip. The respondents were unable to seat.

Keywords : comuter line , election , mode , transportation
ESTIMASI RISIKO KERUGIAN EKONOMI AKIBAT BANJIR ROB MENGGUNAKAN SISTEM INFORMASI GEOGRAFIS DI KECAMATAN PENJARINGAN, JAKARTA UTARA
Authors: Purnama Setyawan , Marfai Muh. Aris , Anggraini Dini Feti , Cahyadi Ahmad
Published: February 2020

ABSTRACT

As a coastal area, North Jakarta face global climate change i.e sea level rise. This phenomena can cause some negative impact to the usage of the area. The objectives of this research is to estimate economic risk caused rob flood from sea with some scenariosof sea water level. The development of flood rob mapping method incoastal area is carried out by neighbourhood operation in Geograhic Information System (GIS) based raster. Economic risk analysis is carried out by overlay of Flood Hazard Map in some scenarios and Land Use Map in certain economic value.The result of research show that economic risk that caused by flood rob 30 cm high is Rp 424.318.821.500,00. Economic risk with 115 cm flood rob high is 2.934.277.188.000,00, whereas economic risk with 200 cm flood rob high is Rp 4.758.739.166.000,00. High risk area is dominated by business area (67,76%) and reguler settlement (24,66%). Key words : rob flood, neighbourhood operation, North Jakarta