bluuebunny/crossref_metadata_2025 huggingface dataset:
La enseñanza de la lectura y la mediación cognitiva en estudiantes de media académica: Estudio de correlación
Authors: Arenas-Parada Alba Luz , Roa-Muños Libardo , Centeno-Villamizar Jairo Abelardo , Téllez-López Kenier Iván
Published: September 2021

Objetivo. Este artículo científico de investigación tiene por objetivo determinar la relación que existe entre el proceso de lectura con apoyo de las TIC y la mediación cognitiva de estudiantes de educación media. La mediación cognitiva a la que se expone el estudiantado en su desarrollo escolar involucra una serie de factores como la intencionalidad, la trascendencia y el sentimiento de competencia que pueden analizarse en función de la actividad lectora. Metodología. Esta investigación de enfoque cuantitativo estableció la correlación entre el proceso de lectura con apoyo de las TIC y la mediación cognitiva; se tomó una muestra estratificada con estudiantes de grados décimo y undécimo de una institución educativa pública. Los datos se obtuvieron a partir de la aplicación de la técnica tipo encuesta; desarrollada en un instrumento en formato cuestionario con escala Likert y se sometieron a revisión de juicio experto, más prueba de normalidad, en SPSS, determinando coeficiente de Pearson. Resultados. Los datos estadísticos, revelaron dificultades en la fluidez y en el sentimiento de competencia de la mediación cognitiva. Conclusiones. Es posible afirmar que existe correlación baja positiva entre el proceso de lectura con apoyo de las TIC y la intencionalidad, la trascendencia y el sentimiento de competencia.
El uso de las TIC como recursos pedagógicos-metodológicos en el proceso de formación del estudiantado universitario del siglo XXI
Authors: Fonseca Cascante Alejandro
Published: September 2021

Information and Communication Technologies (ICTs) have become resources for everyday use for the population; thus, the need to integrate them into the higher education field in order to obtain their maximum benefits possible emerges. Therefore, it cannot be denied that they offer a series of tools that can be used by students in the development of their training process. Human beings never stop learning; hence, ICTs are constantly evolving to adapt to the new demands or needs that individuals are presented with. Higher education centers, aware of this reality, consider it essential that teachers are trained and resort to the application of these in their classes, so that the student population recognizes their different contributions and the support they can provide in their professional development, before an undoubtedly changing landscape, where it is necessary to move from an information society to one of knowledge, so as not to lag behind and be able to adapt to the digital era that the global world is promoting.
Desestructurando la mediación pedagógica tradicional: Experiencias y reflexiones de la propia praxis desde la estrategia de enseñanza de pareja pedagógica
Authors: Araya Rodríguez Fiorella
Published: September 2021

This essay corresponds to the praxis generated during the postgraduate studies' program of División de Educología, Universidad Nacional, from January, 2018 to August, 2019. As part of this essay, traditional pedagogical mediation is reconsidered by including an attractive teaching strategy known as co-teaching, which supports the training of professionals in the master’s Program of Education with an emphasis on University Pedagogy at a public university in Costa Rica. To back up this proposal, the essayist turns to her self-reflection, as well as theoretical references and the analysis of shared experiences by different authors, which show the strengths around the construction of new knowledge in the field of Costa Rican pedagogy at the higher education level.
Pedagogía de la música en la educación superior costarricense: Un acercamiento crítico hacia la descolonización de los procesos de enseñanza-aprendizaje
Authors: Espinoza Mora Juan Carlos
Published: September 2021

This text aims at generating a critical review of the pedagogical model that has prevailed in Costa Rica for music education, especially since the so-called cultural reform in the early 1970’s. In the search of alternative educational models, these reflections take stand from a critical perspective to propose a pedagogical epistemology free from the oppressive conditions still found in the Costa Rican music field.
El profesorado de francés lengua extranjera (FLE) del siglo XXI: Un profesorado empoderado
Authors: Benavides V. Jimena
Published: September 2021

The text is a self-reflexive pedagogical essay in which the analysis carried out by a university professor of French as a Foreign Language is described during her postgraduate process. It deals with topics such as the needs of a beginner professor, the characteristics of the university professor of the 21st century, as well as those of an FFL professor. The reflection comes after recognizing the importance of the pedagogical component for the training of university professors and the challenges that a university professor of the 21st century has to face, who must understand how transcendental his or her work is in the training of future professionals.
Breve acercamiento a la literatura árabe
Authors: Calderón Benavides Juan Roberto
Published: September 2021

Se explora el asunto de la literatura árabe.
La huida imposible ("Rota la ternura", José Marín Cañas)
Authors: Pérez Miguel Rafael
Published: September 2021

Se estudian los relatos en «Rota la ternura».
Aspectos folklóricos en Cuentos de mi tía Panchita
Authors: Cantillano Odilie
Published: September 2021

Se intenta demostrar el carácter internacional, la realción con la tradición hispánica y el vínculo con la tradición oral y literaria en los Cuantos de mi tía Panchita, de Carmen Lyra.
«La Tremenda Corte»: un caso de lingüisticidio
Authors: Ruiz Blanca Estela
Published: September 2021

Se analiza el manejo lingüístico en los personajes del programa de televisión «La Tremenda Corte».
Etnoornitología guatusa
Authors: Pizarro Chacón Ginneth
Published: September 2021

Es un trabajo en el ámbito de la etnosemántica referido a las biotaxonomías que se enfoca en la descripción taxonómica de las aves del guatuso.
La crítica en las revistas literarias en Costa Rica
Authors: Ovares Flora
Published: September 2021

[Revistas literarias costarricenses]
Versos y reversos: a propósito de la voluntad, la lectura y el Quijote
Authors: Baltodano Román Gabriel
Published: September 2021

Se describen y analizan ciertos procedimientos de la escritura cervantina, que ponen en entredicho el relato como discurso. Se muestra que en el Quijote aparecen los fundamentos estético-ideológicos que plantean la ambigüedad entre ficción y realidad; entre verosimilitud y fantasía; entre lectura y parodia. La lectura, en el interior de la novela, se convierte en un acto de voluntad de hacer de la ficción una aventura contra lo establecido y lo convencional; no hay un discurso único, sino voces heterogéneas que comparten el saber.A description is provided of certain procedures found in Cervantes writing, which question the story as discourse. It is shown that in Don Quixote there are esthetic and ideological foundations which suggest the ambiguity existing between fiction and reality; between verisimilitude and fantasy; between reading and parody. Reading, within the novel, becomes the willingness to convert fiction into an adventure going against cultural conventions; there is not just one line of discourse, but rather a number of heterogeneous voices that share knowledge.
El Lazarillo de Tormes: texto carnavalesco. Contra las lecturas satíricas y erasmistas
Authors: Ramírez Caro Jorge
Published: September 2021

El estudio plantea la índole carnavalesca, deliberadamente ambigüa entre el burlón y el burlado, mediante el recurso de la parodia. Así, la tradición popular de la risa se sobrepone al presunto carácter moralizante, didáctico y serio que la crítica le ha atribuido al Lazarillo de Tormes. En vez del atributo picaresco, a lo largo de los episodios hay una voluntad de escenificación del escarnio público, sin ninguna intención ejemplarizante; la vida del personaje apunta al contacto directo con lo mundano, lejos del misticismo o la mera contemplación.This study discusses carnival literature, which-by means of parody deliberately expresses ambiguity between the one who ridicules and the one who is ridiculed. Thus the popular tradition of laughter appears more important than the severe, didactic, moralizing intention which has been attributed to Lazarillo de Tormes. Instead of picaresque features, in all of the episodes an effort is made to mock the character in public, but without any intention of acting as an example; the life of Lazarillo is real, not symbolic or contemplative.
La construcción de la identidad nacional patriarcal en Misterio, de Manuel Argüello Mora
Authors: Singer Deborah
Published: September 2021

Se desarrolla la tesis de que esta novela costarricense de finales del siglo XIX configura literariamente la noción de lo costarricense, patrocinada por una ideología patriarcal, de origen oligárquico, de parte de la élite en el poder. Amparada al discurso realista, en la obra se procura dar cuenta de una identidad costarricense. Sobre esto se hace un esbozo teórico a partir de lo cual se ponen en evidencia los procedimientos discursivos del relato de Argüello Mora, para afirmar una patria idealizada o sólo parcialmente histórica.This article develops the thesis the Costa Rican novel, Misterio, of the late 19th century is a literary configuration of the Costa Rican identity, supported by a patriarchal ideology with oligarchic origins of the elite who are in power. Based on the discourse of realism, the concept of nationality is shown. A theoretical framework is outlined in order to present the narrative techniques used by Argüello Mora, and show how they were used to construct an idealized country which is only partially historical.
Deconstruyendo la originalidad y la autoría: la de-construcción del traductor "no literario" como orquestador/autor de los textos traducidos
Authors: Vargas Gómez Francisco Javier
Published: September 2021

El traductor no literario se ha visto como copista o imitador, en contraposición al autor o al traductor literario, considerados como autores por la originalidad que imprimen a sus textos. Sin embargo, al eliminar los conceptos tradicionales de autoría única y originalidad y proponer en su lugar los conceptos de autoría múltiple e intertextualidad, la deconstrucción permite al traductor no literario homologarse a la figura del autor.Traditionally, non-literary translators have been given the role of the copyist. The author and the literary translator, on the other hand, are seen as authors because of the originality they give to their works. Nevertheless, from the point of view of deconstructive theories, the non-literary translator fulfills the role of the author since deconstruction eradicates the traditional concepts of authorship and originality in favor ofthe concepts of multiple authorship and tertextuality.
Selecting Reading Materials Wisely
Authors: Jiménez Arias Ivannia
Published: September 2021

Se analizan criterios por tenerse en cuenta en la selección de materiales para el desarrollo de la comprensión de lectura en una segunda lengua. Se propone una alternativa para elegir textos. La exploración de estos aspectos resulta muy útil en los cursos de comprensión de lectura al tenerse al estudiante como punto de partida.An analysis is carried out on criteria for selecting materials for the development of reading comprehension in a second language. A proposal for selecting reading texts is described. This approach is very useful in reading comprehension courses because it is student-centered.
La société française à travers la chanson
Authors: Boza Araya Virginia
Published: September 2021

La canción es una expresión popular ligada a las culturas y a las tradiciones del pueblo. Suele acompañar la evolución de la sociedad evocando sus alegrías, tristezas, decepciones y demás hechos de su vida cotidiana. En el campo de la didáctica del Francés como lengua extranjera, la canción ofrece a los profesores la posibilidad de diversificar y ampliar las perspectivas y las aplicaciones sociolingüísticas en la clase. Un análisis minucioso realizado en dos mil canciones entre 1970 y 2003 permitió estudiar la evolución de la sociedad francesa. Los resultados de este estudio recopilados en La chanson, miroir d'une société demuestran los efectos del desarrollo económico en la sociedad.La chanson a toujours été une expression profondément populaire, ancrée da s les cultures et les traditions des peuples. Elle suit l'évol ution de la société et des individus en évoquant autant leurs joies, leurs malaises que tous les problèmes qu'ils affrontent au quotidien. Dans le domaine de la didactique du Français langue étrangere, la chanson offre aux enseignants la possibilité de diversifier, d'élargir les approches et les applications sociolinguistiques dans la c1asse. Une analyse approfondie effectuée sur 2000 chansons des années 1970 a 2003 a permis de suivre l'évolution de la société française. Les résultats de cette étude rapportés dans La chanson, miroir d'une société soulevent les effets du développement économique sur la société .
Juegos referenciales y configuraciones espaciales en el universo cortazariano: "Ahí, pero dónde, cómo"
Authors: Aguilar Alma Rosa
Published: September 2021

Se estudia la duplicación espacial en relación con la creación de lo fantástico en la obra de Cortázar.
Du français sur objectifs spécifiques pour les professionnels du tourisme
Authors: Santander Sotomayor Paula
Published: September 2021

En este artículo se analiza la experiencia de un proyecto para la elaboración de cuatro módulos de francés para guías turísticos, los diferentes elementos que se incluyen para este fin y su posible adaptación a la metodología de «Vacances Cubaines» en el contexto costarricense.Dans cet article, on analyse l'expérience d'un projet de construction de quatre modules de français pour des guides touristiques, les différents éléments qui entrent en jeu et son adaptation a la méthodologie de «Vacances Cubaines» dans un contexte costaricien.
Costa Rica et son avenir
Authors: Biolley Paul
Published: September 2021

PAUL BIOLLEY ( 1862-1908), fue un destacado educador suizo, que llegó a Costa Rica en 1886, durante la administración de Bernardo Soto, en la que fungía como Secretario de Instrucción Pública Mauro Fernández. Fue contratado como profesor de la denominada entonces Escuela Normal y Modelo, que se transformó luego en el Liceo de Costa Rica. Desarrolló una muy notable labor docente en el campo de las ciencias naturales, y muchos de sus trabajos sobre Costa Rica gozan aún de prestigio y valor. Les dio un innegable impulso a las ciencias naturales, mediante variadas y constantes investigaciones; entre ellas sobre los moluscos de la Isla del Coco, sobre los invertebrados y otros temas más. También fue un notable traductor de obras científicas, sociales e históricas, varias de ellas relacionadas con Costa Rica.      En 1889 publicó en París, como fruto de su indudable interés por el presente y el futuro de nuestro país, la obra Costa Rica et son avenir [Costa Rica y su porvenir]. Es un estudio sobre el país en general, sus habitantes, sus zonas geográficas, sus rasgos culturales, su industria, comercio y hacienda. El capítulo final, «L'avenirr» , es de singular agudeza. Ya con tres años de haber vivido en Costa Rica, estuvo en condiciones de detectar aspectos esenciales de la historia nacional, del talante de sus pobladores y de muchos otros aspectos que, leídos desde hoy, parecen haberse escrito en nuestros días. Se trata de uno de los primeros documentos, escritos en lengua francesa, sobre la historia y la cultura costarricenses, de especial valor por dar cuenta de la percepción que de la nación se tenía a finales del siglo XIX.     LETRAS rescata, en esta sección «Documentos», una muestra escrita del legado de un brillante pedagogo y pensador, quien, como muchos otros extranjeros, se afincó en nuestro medio y trabajó con lealtad y generosidad en su nueva patria que fue, en el caso de Biolley, la definitiva. La Dirección de esta revista les agradece a los encargados de la Biblioteca de Libros Antiguos y Especiales, de la Universidad Nacional, haber permitido reproducir este documento, que forma parte del acervo bibliográfico de esa valiosa colección.
Mūsų recenzentai
Authors: Psichologija
Published: September 2021

...
Influence of liposomal drug on the intensity of proteins oxide modification processes in subclinical mastitis of cows
Authors:   Podillia State University, 13 Shevchenko str., Kamianets-Podilskyi, Khmelnytsk region, 32316, Ukraine, Chepurna V. A. , Suprovych T. M. ,   Podillia State University, 13 Shevchenko str., Kamianets-Podilskyi, Khmelnytsk region, 32316, Ukraine, Vishchur O. I. ,   Institute of Animal Biology NAAS, 38 V. Stus str., Lviv, 79034, Ukraine, Mizik V. P. ,   Podillia State University, 13 Shevchenko str., Kamianets-Podilskyi, Khmelnytsk region, 32316, Ukraine, Solovodzinska I. Ye. ,   Lviv National Agrarian University, 1 Volodymyr Velykyi str., Dubliany, Zhovkva district, Lviv region, 80381, Ukraine
Published: September 2021

The article contains the experimental studies of the liposomal drug based on plant raw materials ― hypericum (Hypericum perforatum L.) effect on the intensity of oxidative modification of proteins (OMP) in the blood and milk of cows with subclinical mastitis. Studies have shown that cows with signs of subclinical form of mastitis in the serum have an increase in the content of aldehyde-derived OMP370 and ketone-derived OMP430, respectively, 1.3 and 1.2 times relative to similar indicators in healthy animals. In the milk of sick cows, the content of derivatives OMP370 and OMP430 was1.99 and 2.29 times higher, respectively, than in animals of the control group. At the beginning of the study sick cows’ milk was recorded a significantly low value of the activity of the enzymatic link of antioxidant protection ― superoxide dismutase. At the same time, a 2.6-fold (P<0.001) increase in the number of somatic cells was noted compared to their number in the milk of clinically healthy cows. Intracisternal injection of liposomal drug to cows caused a decrease in the intensity of oxidative processes. In the blood of sick cows the content of aldehyde derivatives OMP370 on the 9th day of the experiment was 23.1% (P<0.05) less than before the drug, and in milk the content of OMP370 decreased by 61.8% (P<0.01). Similar changes were observed with respect to the level of ketone derivatives. In particular, on the 9th day of the experiment, the content of OMP430 decreased by 11.7% (P<0.05) compared with its value in the blood of sick animals before the introduction of the study drug, and in milk it decreased by 64.2% (P<0.01). During the treatment on the 9th day of the experiment, the number of somatic cells in milk decreased by 41.8% (P<0.01). In the course of treatment on the 3rd and 9th day there was a tendency to increase superoxide dismutase activity in the milk of sick cows compared with the beginning of the experiment. Thus, intracisternal injection of liposomal drug to cows with subclinical mastitis leads to a decrease in aldehyde and ketone derivatives of proteins oxidative modification in serum and milk. At the same time, an increase in the activity of the enzymatic link of antioxidant protection and a decrease in the number of somatic cells in the milk of cows were recorded.
Diagnostic value of integrated immunohematological indices as markers of chronic stress in laying hens
Authors:   National University of Life and Environmental Sciences of Ukraine, 15 Heroyiv Oborony str., Kyiv, 03041, Ukraine, Osadcha Yu.
Published: September 2021

The study of stress in the conditions of industrial technologies of keeping laying hens and determining the level of technological stressors influence on the physiological state of poultry is a necessary condition for the development of new methods of stress prevention in choosing the best ways to keep them. The aim of the study was to determine the informativeness of integrated immunohematological indices for the diagnosis of stress-induced disorders in laying hens under the influence of technological stressors of varying intensity. Chronic technological stress was modeled by long-term keeping of laying hens at high planting density. The intensity of the stressor was determined by increasing the density of laying hens. Integral immunohematological indices were determined on the basis of an extended general blood test. It has been found that in laying hens, which due to prolonged exposure to high density were in a state of chronic stress, there is a high level of endogenous intoxication and impaired immunological reactivity, as evidenced by increased Leukocyte shift index, Immunoreactivity index, Leukocyte to erythrocyte sedimentation rate ratio, lymphocyte to monocyte ratio, heterophil to monocyte ratio. It is shown that under chronic stress in laying hens there is activation of the cellular part of the immune system, active adaptive response of white blood, as well as the predominance of delayed-type reactions over immediate-type hypersensitivity, as indicated decrease in lymphocyte-granulocyte index, general index, lymphocytic index and lymphocyte to eosinophil ratio. Thus, integrated immunohematological indices are promising markers for the diagnosis of chronic stress in laying hens.
Features of the influence of oat extract on the antioxidant activity of goose liver
Authors:   Bogdan Khmelnitsky Melitopol State Pedagogical University. 20 Hetmanska str., Melitopol, Zaporizhzhya district, 72312, Ukraine, Nikolaeva Yu. V. , Danchenko O. O. ,   Dmytro Motornyi Tavria state agrotechnological university, 18 Bohdan Kmelnytsky ave., Melitopol, Zaporizhzhya district, 72312, Ukraine
Published: September 2021

The use of antioxidants in poultry feeding helps to relieve stress of various etiologies. Natural antioxidants have a number of advantages over synthetic ones. The aim of the study was to determine the effect of Avena sativa oat extract on the peculiarities of the functioning of the antioxidant system of goose liver during the physiological stress of contour and juvenile feather formation (from the 14th to the 56th day). The state of the antioxidant system in liver tissues was determined by the coefficient of antioxidant activity, the content of the final products of lipoperoxidation, the activity of antioxidant enzymes and the content of fat-soluble vitamins. The results of the experiment showed that the goslings of the control group during the formation of contour feathers have a decrease in antioxidant activity of the liver by 2.36 times, and juvenile — 1.90 times compared to the initial value of this indicator. Adding oat extract to the diet of geese during feather formation increases the antioxidant activity of their liver. Under the influence of the extract, the physiological stress associated with the formation of contour feathers (28 days) is significantly reduced by reducing the content of the main substrate of lipoperoxidation of unsaturated fatty acids, despite the decrease in the activity of all antioxidant enzymes. Increasing antioxidant activity in the liver during the formation of juvenile feathers is due to the inclusion of alternative mechanisms of antioxidant protection, implemented by increasing the activity of endogenous antioxidants: superoxide dismutase by 29.6 (P≤0.05), catalase by 34.6% (P≤0.05), glutathioperoxidase by 41.2% (P≤0.01), and the content of vitamin E by 32.7% (P≤0.05) and β-carotene by 30.9% (P≤0,05). Under the influence of the extract there is not only a significant increase in the weight of geese at the end of the experiment, but also an improvement in their pterylographic performance. Therefore, in the future, it would be advisable to conduct similar studies on wild bird species in kennels, as the process of feather formation is of fundamental importance for these birds.
O status público da instituição comunitária
Authors: Fortunato Raquel Paula
Published: September 2021

Este ensaio discute a educação superior como um bem público, criticando a sua transformação em um mero serviço de mercado. Face ao esgotamento dos modelos estatista e privatista de organização acadêmica, incapazes de dar conta da complexidade que permeia a realidade empírica, busco refletir e analisar o conceito de bem público no contexto público não estatal. O campo investigativo teórico apoia-se em Dewey, Nussbaum e Marginson, dentre outros, com vistas a evidenciar concepções de público, conceitos de compromisso social e de colegialidade, bem como os desafios contemporâneos das instituições de educação superior diante da hegemonia do pensamento neoliberal. Por fim, através de dedução lógica entre tal referencial teórico e revisão da literatura sobre as instituições comunitárias, argumento que, para manterem o status e a concepção de públicas, faz-se necessário que tais universidades promovam ações voltadas ao bem comum, a responsabilidade social e a gestão colegiada e democrática.
A relação escola-família nos documentos da política para a educação básica
Authors: Casanova Letícia Veiga , Ferreira Valéria Silva
Published: September 2021

A presente pesquisa analisou os tipos de relações escolas-famílias delineadas pelos documentos da política para a Educação Básica a partir da LDB No 9.394/96. O caminho metodológico teve como referência a análise arqueológica de Foucault, que busca profundidade, reconhece as posições e as funções que os sujeitos ocupam e procura definir as unidades, os conjuntos, as séries e os jogos de relações em um tecido documental. Os resultados apontam o movimento empresarial como um dos atores que estão influenciando a elaboração dos documentos e, dessa forma, trazem os valores de uma perspectiva de mercantilização para os processos da educação e das relações escolas-famílias. Uma relação que mobiliza as famílias a participarem da melhoria da qualidade da educação. Contudo, a qualidade é medida pela performance nos testes padronizados e, assim, cabe às famílias fiscalizarem o gerenciamento das performances mensuráveis.
Ética em pesquisa
Authors: Pinto Cesar Augusto Sadalla , Mendonça Luciana de Oliveira Souza , Do Monte Thaidys da Conceicao Lima , Nunes João Batista Carvalho
Published: September 2021

Objetivou-se analisar como as dissertações de uma instituição de ensino cearense abordam as questões éticas na pesquisa. Realizou-se um estudo quantitativo com 104 dissertações, considerando a presença de cuidados éticos no resumo; a presença de seção sobre os aspectos éticos da pesquisa; a presença de Termo de Consentimento Livre e Esclarecido; e a aprovação por um Comitê de Ética em Pesquisa. Realizou-se análise estatística não-paramétrica por meio do teste de Kruskal-Wallis, com nível de significância de 5%, mediante utilização do software SigmaStat 3.5. Os dados revelaram que a maioria das dissertações não atendem na íntegra a Resolução CNS nº 466/2012, apesar disso fazem referências éticas ao longo do trabalho. Não houve diferenças estatisticamente significantes (p>0,05) em relação às categorias de análise, em função do ano de defesa.
Instrumento de pesquisa para prevenção da evasão nas instituições de ensino superior à distância
Authors: Da Costa Oberdan Santos , Gouveia Luis Borges , Da Cunha Luis Simoes
Published: September 2021

O objetivo deste estudo é relatar as etapas de construção do instrumento de pesquisa para prevenção da evasão, nas instituições de ensino superior à distância. O instrumento foi construído com a finalidade de coletar informações sobre o apoio acadêmico, recebido pelos estudantes, às mudanças nas circunstâncias da vida do estudante durante o processo de formação, aspectos motivacionais, experiência de aprendizagem em geral e características individuais. No estudo foi adotada uma abordagem quantitativa, com base em estudos nacionais e internacionais. Os resultados apontaram 83,3% de concordância entre os juízes para os constructos da motivação, apoio (tutor, familiar e financeiro) e 100% de concordância para os constructos sexo, idade, educação anterior e situação de trabalho. Esses dados podem ser úteis aos pesquisadores e estudiosos para o alinhamento do foco e do objetivo de seus estudos.
Development of Remote Jobs as a Factor to Increase Labor Efficiency
Authors: Maghlaperidze Eka , Kharadze Natalia , Kuspliak Halyna
Published: September 2021

The purpose of the study was to assess the effectiveness of remote work and the determining factors of its development. Based on the survey for December 2020 - January 2021, with 528 employees of insurance companies in Georgia, the features of remote work have been determined. The factors influencing the effectiveness of remote work were substantiated by the Principal Component Analysis (PCA). Structural modeling confirmed the qualitative nature of the influence of the intensity of remote work on the level of its effectiveness, taking into account the factors of its effectiveness. The regularities and priority of the impact of the characteristics of the effectiveness of remote work depending on the intensity of the remote work have been substantiated. The optimal volume of remote work has been determined empirically. Its maximum efficiency is ensured in terms of increasing the productivity and satisfaction of employees of insurance companies.
Ferulic acid attenuates osteoporosis induced by glucocorticoid through regulating the GSK-3β/Lrp-5/ERK signalling pathways
Authors: Zhou Wei , Chen Bo , Shang Jingbo , Li Renbo
Published: September 2021

Objective

To evaluate in-vivo and in-vitro effects of ferulic acid (FA) on glucocorticoid-induced osteoarthritis (GIO) to establish its possible underlying mechanisms.

Methods

The effects of FA on cell proliferation, cell viability (MTT assay), ALP activity, and mineralization assay, and oxidative stress markers (ROS, SOD, GSH LDH and MDA levels) were investigated by MC3T3-E1 cell line. Wistar rats received standard saline (control group) or dexamethasone (GC, 2 mg−1 kg) or DEX+FA (50 and 100 mg−1 kg) orally for 8 weeks. Bone density, micro-architecture, bio-mechanics, bone turnover markers and histo-morphology were determined. The expression of OPG, RANKL, osteogenic markers, and other signalling proteins was assessed employing quantitative RT-PCR and Western blotting.

Results

The findings indicated the elevation of ALP mRNA expressions, osteogenic markers (Runx-2, OSX, Col-I, and OSN), and the β-Catenin, Lrp-5 and GSK-3β protein expressions. FA showed the potential to increase MC3T3-E1 cell differentiation, proliferation, and mineralization. FA increased oxidative stress markers (SOD, MDA, and GSH) while decreasing ROS levels and lactate dehydrogenase release in GIO rats. The OPG/RANKL mRNA expression ratio was increased by FA, followed by improved GSK-3β and ERK phosphorylation with enhanced mRNA expressions of Lrp-5 and β-catenin.

Conclusion

These findings showed that FA improved osteoblasts proliferation with oxidative stress suppression by controlling the Lrp-5/GSK-3β/ERK pathway in GIO, demonstrating the potential pathways involved in the mechanism of actions of FA in GIO therapy.
The “GG” genotype of rs26802 variant in the ghrelin gene is a potential protective factor against nonalcoholic fatty liver disease
Authors: Rezamand Gholamreza , Mahmoudi Touraj , Tabaeian Seidamir Pasha , Farahani Hamid , Shahinmehr Fatemeh , Nobakht Hossein , Dabiri Reza , Asadi Asadollah , Mansour-Ghanaei Fariborz , Zali Mohammad Reza
Published: September 2021

Background

Nonalcoholic fatty liver disease (NAFLD) is an emerging global chronic liver disease worldwide. Considering the powerful association between NAFLD, insulin resistance (IR) and obesity, as well as the key role of ghrelin in these metabolic disorders, we hypothesized that some single nucleotide polymorphisms (SNPs) of the ghrelin (GHRL) and ghrelin receptor (GHSR) genes might be associated with NAFLD.

Methods

We conducted a case-control retrospective study of 150 cases with biopsy-proven NAFLD and 155 controls. The diagnosis of NAFLD was established before the start of the genotyping process. All the 305 subjects were genotyped for GHRL SNP rs26802 or -501T>G and GHSR SNP rs572169 or Arg159Arg using the PCR-RFLP method.

Results

The GHRL rs26802 “GG” genotype compared with the “TT” genotype and “TT+TG” genotype appears to be a marker of decreased NAFLD susceptibility even after adjustment for confounding factors (P = 0.006; OR = 0.14, 95% CI = 0.03–0.56 and P = 0.003; OR = 0.16, 95% CI = 0.05–0.53, respectively). However, we observed no significant difference in genotype or allele frequencies between the cases and controls for GHSR SNP rs572169.

Conclusions

These findings proposed, for the first time, that the GHRL rs26802 “GG” genotype has a protective effect against NAFLD. Nonetheless, this observation warrants further investigations in other populations.
First Russian experience in liver and kidney transplantation from donors with out-of-hospital cardiac arrest: 3 years’ results
Authors: Reznik O. N. , Skvortsov A. E. , Daineko V. S. , Loginov I. V. , Kutenkov A. A. , Komedev S. S. , Teplov V. M. , Kuzmin D. O. , Ananiev A. N. , Uliankina I. V. , Gogolev D. V. , Kukushkin A. A. , Malyshev M. E. , Boykov A. A. , Savello V. E. , Morozov A. N. , Bagnenko S. F.
Published: September 2021

Introduction. In megacities, the use of organs obtained from those who died as a result of sudden out-of-hospital cardiac arrest (OHCA) for transplantation is one of the promising ways of addressing the problem of organ donor shortage. In St. Petersburg, the model of transition from life support via extracorporeal membrane oxygenation (ECMO) of patients after OHCA to ECMO life support for organs of potential donors was tested for the first time.

Materials and methods. In order to implement the program, round-the-clock ECMO and transplantation teams were organized at the inpatient emergency ward of Pavlov First St. Petersburg State Medical University. Interaction with the St. Petersburg City Emergency Station, St. Petersburg was established. The protocol of work with potential donors brought to the hospital after a sudden circulatory arrest was developed, approved by the ethics committee, and implemented in clinical practice. This was the first in Russia and in international practice. Between 2017 and 2020, 67 patients with sudden OHCA were brought to the inpatient emergency ward. In 4 (5.97%) cases, advanced cardiovascular life support was successful, and 11 (16.42%) patients became effective donors. Mortality among this group of patients without subsequent postmortem donation was 77.61% (52 patients).

Results. Liver transplantation from non-heart-beating donors (NHBDs) whose blood circulation was restored by ECMO (ECMO NHBD) was performed in 5 recipients who were in severe condition against the background of liver failure. In 1 (20%) case, there was severe liver allograft dysfunction for 33 days with subsequent complete restoration of function. Kidney transplantation was performed in 22 patients. Immediate graft function occurred in 10 (45.45%), while delayed function occurred in 12 (54.55%) patients. Kidney graft survival was 86.4%, kidney graft recipient survival was 95.5%, liver graft recipient survival was 80%, and the follow-up period was 24.1 ± 7.15 months.

Conclusion. The use of ECMO to save the lives of patients with sudden OHCA can be implemented in conditions of a high degree of organization and synchronization of the work of the city emergency medical station and the emergency department of a multidisciplinary hospital. If cardiopulmonary resuscitation with ECMO (ECMO CPR) fails, it is possible to launch the ECMO NHBD donor program. Long-term outcomes of liver and kidney transplantation from ECMO NHBD are consistent with those using organs from brain-dead donors. Widespread implementation of the new organ donation model will increase the availability of transplant care.
Diagnostic value of microRNA-27 and -339 in heart transplant recipients with myocardial fibrosis
Authors: Shevchenko O. P. , Velikiy D. A. , Sharapchenko S. O. , Gichkun O. E. , Marchenko A. V. , Ulybysheva A. A. , Pavlov V. S. , Моzheikо N. P. , Кoloskovа N. N. , Shevchenko A. O.
Published: September 2021

Myocardial fibrosis plays a key role in the pathogenesis of heart failure. A family of small non-coding signaling molecules, microRNAs (miRNAs), has been identified as promising profibrogenic biomarkers capable of signaling a possible risk of adverse events after heart transplantation.

Objective: to identify and evaluate the diagnostic significance of miRNAs, as well as comprehensive miRNA-based tests in heart recipients with graft myocardial fibrosis.

Materials and Methods. The study included 83 heart recipients aged 16 to 64 (48.4 ± 13.1) years. The expression levels of five microRNAs (miR-27, -101, -142, -339, -424) in venous blood plasma were measured by quantitative real-time polymerase chain reaction; galectin-3 serum levels were determined by enzyme immunoassay.

Results. Morphological signs of graft myocardial fibrosis were verified in 48 recipients. The miR-27 and miR-339 expression levels were significantly higher in heart recipients with myocardial fibrosis than in those without myocardial fibrosis (p = 0.018 and p = 0.043, respectively). Diagnostically significant threshold levels of miR-27 and miR-339 for detection of myocardial fibrosis in heart transplant recipients were determined (–4.33 and –5.24 units, respectively). The relative risk of detecting graft myocardial fibrosis in recipients with miR-27 expression value above the threshold level was RR = 1.5 ± 0.157 [95% CI 1.104-2.039], p = 0.009; for miR-339, RR = 1.31 ± 0.130 [95% CI 1.018-1.692], p = 0.036. When miR-27 expression levels and galectin-3 serum levels simultaneously exceeded their estimated thresholds, the risk of transplanted heart myocardial fibrosis increased to RR = 2.7 ± 0.456 [95% CI 1.090-6.524], p = 0.032; when miR-339 and galectin-3 simultaneously exceeded threshold values, the risk was RR = 2.0 ± 0.316 [95% CI 1.076-3.717], p = 0.028).

Conclusion. The miR-27 and miR-339 expression levels are associated with the presence of fibrotic changes in the graft myocardium. The combination of molecular-genetic and proteomic biomarkers in one test improves the diagnostic characteristics of these expressions with respect to post-transplant complications in heart recipients.
Career Adapt-Abilities Scale (CAAS-Brasil): Propriedades psicométricas, diferenças em função de variáveis sociodemográficas e padrões normativos
Authors: Salvador Ana Paula , Ambiel Rodolfo Augusto Matteo , Martins Gustavo Henrique
Published: September 2021

O objetivo deste artigo foi propor padrões normativos para a Career Adapt-Abilities Scale (CAAS-Brasil) considerando diferenças em função das variáveis sociodemográficas: sexo, estado civil, faixa etária, escolaridade e faixa de rendimento. A amostra foi composta por 2999 indivíduos, idades variando de 14 a 77 anos, maioria do sexo feminino (63%) e representantes de 21 estados brasileiros. As propriedades psicométricas da CAAS-Brasil foram investigadas por meio de Teoria de Resposta ao Item e coeficiente Ômega. Os resultados evidenciaram invariância para a CAAS-Brasil e maiores diferenças de médias nas variáveis faixa etária, escolaridade e faixa de rendimento. A partir disso, foram apresentados padrões normativos para a amostra geral e dividida considerando as variáveis que apresentaram diferenças. Os padrões normativos apresentados neste artigo possibilitarão que profissionais de orientação profissional e de carreira interpretem, com base em normas, os escores de adaptabilidade de carreira de seus orientandos, tornando a avaliação mais substantiva.
A Plasma-Generating N-95 Respirator Decontamination Unit Created from a Microwave Oven
Authors: Ruzic David N. , Oh Chamteut , Puthussery Joseph V. , Patel Dhruval , Jeckell Zachary , Verma Vishal , Nguyen Thanh H.
Published: September 2021

Wearing a mask population-wide is an important preventive measure in addressing COVID-19 and potential future pandemics. We showed how a household microwave oven, a coat-hanger, and a coffee cup can generate plasma that can be used to decontaminate N95 respirators in less than 1 minute. We proved that microwave-generated plasma can reduce infectivity of the Tulane virus and the transmissible gastroenteritis virus (TGEV) on N95 respirators by > 3-log10. We further studied the Tulane virus by molecular assays to understand inactivation mechanisms, and we found that the plasma damages both viral proteins and genomes. Spectroscopy of the plasma revealed OH and C-containing radicals as the most prevalent active species expected to cause virus inactivation. The respirators still maintained filtration and fit even after 10 cycles of the plasma treatment. We believe that microwave-generated plasma is an easily accessible respirator
decontamination technique that everyone could use for safe respirator reuse.
A cooperative heterogeneous vehicular clustering framework for efficiency improvement
Authors: Ahmad Iftikhar , Noor Rafidah Md , Ahmed Zaheed , Umm-e-Habiba  , Akram Naveed , García Márquez Fausto Pedro
Published: September 2021

Heterogeneous vehicular clustering integrates multiple types of communication networks to work efficiently for various vehicular applications. One popular form of heterogeneous network is the integration of long-term evolution (LTE) and dedicated short-range communication. The heterogeneity of such a network infrastructure and the non-cooperation involved in sharing cost/data are potential problems to solve. A vehicular clustering framework is one solution to these problems, but the framework should be formally verified and validated before being deployed in the real world. To solve these issues, first, we present a heterogeneous framework, named destination and interest-aware clustering, for vehicular clustering that integrates vehicular ad hoc networks with the LTE network for improving road traffic efficiency. Then, we specify a model system of the proposed framework. The model is formally verified to evaluate its performance at the functional level using a model checking technique. To evaluate the performance of the proposed framework at the micro-level, a heterogeneous simulation environment is created by integrating state-of-the-art tools. The comparison of the simulation results with those of other known approaches shows that our proposed framework performs better.
Preparation and mechanical properties of green epoxy/chitosan/silver nanocomposite
Authors: Mahmud Abu , Dev Chaity , Meem Moumita Tasnim , Gafur Md Abdul , Hoque Md Asadul
Published: September 2021

Epoxy is being extensively used in various engineering and structural applications. Epoxy is non-biodegradable, thus creating ecological problems. Apart from ecological problems, epoxy resin shows poor biofouling prevention in marine, freshwater and offshore environments. In the search for an eco-friendly solution to this problem, epoxy/chitosan/silver nanocomposites were devised. Chitosan was extracted from shrimp shells following deacetylation of chitin, and silver (Ag) nanoparticles synthesized using a chemical reduction process of silver salts. All the composite samples were prepared utilizing the solution casting method. The X-ray diffraction pattern and Fourier transform infrared analysis predict the successful creation of silver nanoparticles and chitosan, respectively. Different mechanical testings elaborate the fact that addition of chitosan into epoxy resin increases hardness, lowering tensile and flexural strength, whereas incorporation of silver nanoparticles reverses those properties, resulting in mechanical properties analogous with neat epoxy resin. Additionally, soil burial biodegradation testing ensured relatively greener characteristics of the final nanocomposites. Herein, the combined effect of chitosan and silver nanoparticles on an epoxy matrix is reported for the first time.
Evaluation of choroidal thickness, retinal nerve fiber layer thickness, macular thickness and retinal vessel diameter by optical coherence tomography in patients with peripheral arterial disease
Authors: SOYDAN Adem , UYAR Enes , KAYMAZ Abdulgani , ULAŞ Fatih , KORMAZ Ufuk Turan Kürşat
Published: September 2021

Aim: To evaluate retinal nerve fiber layer thickness, macular thickness and retinal vessel diameter by optical coherence tomography in patients with peripheral artery disease.

Materials and Methods: 35 patients with a diagnosis of peripheral arterial disease (PAD) and 32 healthy individuals (control group) were included in the study. Retinal thickness (RT), choroidal thickness (CT) in enhanced depth imaging (EDI) mode, retinal nerve fiber layer (RNFL) thickness, retinal artery and vein diameters were measured with optical coherence tomography (OCT) device.

Results: The mean age of the PAH group included in the study was 59.4±11.9 and the mean age of the control group was 55.5±5.3 years. A statistically significant difference was observed between the two groups in the values obtained from the CT in the subfoveal region of the EDI measured from three different regions and the nasal quadrant of the RNFL measured from 7 quadrants (p=0.03 and p=0.03, respectively). On the contrary, no statistically significant difference was observed in EDI and other measurements of RNFL, RT values, artery and vein diameters (p values were between 0.08-1.00).

Conclusion: In patients with PAD, it is important to determine the RNFL and CT to be thinner. It can be a guide in more comprehensive studies in the future.
The expression of angiogenic protein Cyr61 significantly increases in the urine of early-onset preeclampsia patients
Authors: BEHRAM Mustafa , OĞLAK Süleyman Cemil
Published: September 2021

Aim: This study sought to compare the expression of the Cysteine-rich 61 (Cyr61) protein in the urine of early-onset preeclampsia (PE) patients with that of the urine of normotensive healthy pregnant women.

Material and method: A total of 80 patients who gave birth from June 2019 to December 2019 were enrolled in this prospective study. The study group comprised 40 pregnant women at 20-34 weeks of gestation who presented with early-onset PE. Gestational age- and body mass index-matched, 40 healthy normotensive pregnant women without proteinuria were included in the control group. We recorded demographic characteristics and urine Cyr61 concentrations of the participants.

Results: The urine Cyr61 protein levels were significantly higher in the early-onset PE group (922.6±1263.1 pg/mL) than those of the control group (499.2±270.2 pg/mL, p
Nobiletin Reduces Lipid Accumulation in Sebocytes and Inhibits PPAR Delta Activation in Epidermal Tissue Models
Authors: E Fedorova , S Li , GL Gusella , A Mosoian
Published: September 2021

Background: Acne vulgaris is a chronic inflammatory disease that affects the majority of the population at some point in their lifetime. Acne pathogenesis is multifactorial with four primary contributors that play a pivotal role in the formation of acne lesions: inflammation, androgeninduced sebum production, abnormal keratinization, and bacterial colonization. Recent studies have demonstrated the anti-inflammatory, anticarcinogenic, anti-diabetic, and anti-lipid properties of certain Polymethoxylated Flavones (PMF) derivatives.