bluuebunny/crossref_metadata_2025 huggingface dataset:
Classification of Social Types in the Media (Based on the Material of Serial Periphrases)
Authors:   Kazan Federal University, Kazan, 420008 Russia, Garaeva V.Yu.
Published: November 2020

The periphrases of humans in the language of the media from the position of secondary (repeated) nomination were studied. The purpose of the study was to identify serial periphrastic lines in media texts sharing the same structural and semantic model. The study is highly relevant due to the fact that personal names serve as a background of the news message by encoding the most important roles of humans in the society. A total of 11 serial peripheral lines were identified. A detailed description of the most frequent serial peripheral lines for naming humans in the language of the media was performed. A new model was introduced for analysis of serial periphrastic lines. It was proved that the formation of serial periphrastic lines in the media is conditioned by both linguistic and extralinguistic factors. The obtained results demonstrate that serial periphrastic lines help to a decrease the number of nominative options and favor the formation of social frames, which saves cognitive efforts of the addressee. The theoretical importance of the research is that the algorithm introduced for investigation of peripheral lines can be extrapolated to other typical descriptive lines. The results of the study can be also helpful in lexicography and teaching special courses on the language of the media and the theory of nomination.
The Swedish Language of Formal Communication in the Modern and Contemporary Times
Authors:   Moscow State University, Moscow, 119991 Russia, Matytsina I.V.
Published: November 2020

Processes typical of the Swedish business language during the modern era were described. The study is of high importance, because this functional style of the Swedish language has been insufficiently investigated despite the regulation and normalization processes in it are of obvious interest to specialists in the Germanic languages. The main research method is synchronic analysis enabling examination and description the material in terms of the existing norms. A wide range of examples were provided to illustrate that in the modern era the language of law gradually gets closer to the language of notifications, rules, orders, regulations, etc., i.e., to documents that are usually implied when talking about officialese (the official and business style). It was concluded that the modern period was marked by not only the distinction between these two stylistic types of text, but also by the fact that they both acquired features common to Swedish non-fiction texts (sakprosan). In the 19th century, these processes were not very evident and, despite some minor innovations, the Swedish business language still contained a number of archaic features revealed in the so-called “substantival sickness” (substantivsjukan). A fundamental change took place in the 20th century and is associated with the spelling reform of 1906, as well as significant changes in such elements of the Swedish business language as syntax, morphology, and vocabulary that emerged mostly in the second half of the 20th century. The results obtained are of great importance for studying the Swedish stylistics, as well as for understanding the essence and roles of language policy in the process of normalizing and codifying the literary language.
The Concept of LERNEN as a Cognitive Dominant of the Educational Discourse (Based on the Material of German Language Textbooks)
Authors:   Samara National Research University, Samara, 443086 Russia, Shukman V.E. , Dubinin S.I. ,   Samara National Research University, Samara, 443086 Russia
Published: November 2020

Comparative analysis of the specifics of representation of the concept of LERNEN as a cognitive dominant of the educational discourse in the modern German language textbooks of elementary level for foreigners was carried out. The aim of this research is to identify lexical elements marking the educational discourse of Germany and verbalizing the concept of LERNEN in the textbooks. In line with this aim, the following tasks were set: to reveal and categorize lexical elements representing the concept of LERNEN in all structural components of the selected textbooks; to quantify the revealed representatives and show their relations graphically; to perform both qualitative and comparative analysis of the representatives of the thematic groups of each textbook separately and in comparison with each other. The main method used during the research was conceptual analysis of the educational discourse on the basis of the textbooks of elementary level. The obtained results demonstrate that the representatives of the concept of LERNEN can be divided into 13 thematic groups. Their quantitative ratio was established on the basis of the textbooks. The thematic groups with a predominant number of representatives were determined. All lexical elements representing the concept of LERNEN were qualitatively investigated and their positions in the educational discourse were established. We found the ways of representing the concept of LERNEN as a large and crucial cognitive dominant and marking it with the help of the studied representatives associated with not only the modern educational discourse in the field of foreign languages learning, but also with the educational policy of Germany in general, which is highly relevant because of the high attraction and active influx of foreign students, tourists, and migrants to Germany. The results obtained are of great importance for further research of the cognitive basis of modern German language textbooks.
Linguistic and Creative Aspects of Representation of the Macroconcept of Life in the Wordplay Poetics of the Story “The Circle” by V.V. Nabokov
Authors:   Belgorod State University, Belgorod, 308015 Russia, Maltseva G.Yu.
Published: November 2020

This paper is based on a detailed analysis of the representation of the concept of circle as a component of the macroconcept of life in the poetic wordplay of the story “The Circle” (‘Krug’) by V.V. Nabokov. In the light of the theory of wordplay poetics, the following non-standard ways of representing the macroconcept of life were revealed: the absence of the concept nominee in the studied direction of association; the involvement of etymological data of the key representative and semantically related associates. The method of N.S. Bolotnova’s associative layer analysis was used to identify implicit meanings and to reveal key elements that can be helpful in decoding the wordplay of the text. It was found that the core of the macroconcept of life is based on the conceptual metaphor “life – circle”, which is characteristic of the Russian linguistic view of the world. The areas of association were singled out by the method of association analysis of the concept and divided into separate blocks, each representing one of the semes (elements of the meaning of the concept of circle) in the story “The Circle” and connected with implicit associations. Taken together, they provide V.V. Nabokov’s complete individual view of the macroconcept of life. The obtained results demonstrate the idiosyncratic character of V.V. Nabokov’s prose. By means of the wordplay poetics of the story “The Circle”, the concept of life reflects the individual view of the world by V.V. Nabokov, and the axiological layer of the concept translates the author’s philosophical views on life.
Lexical and Grammatical Aspects of Direct and Indirect Speech in Turkish News Language
Authors:   Moscow State University, Moscow, 119991 Russia, Alekseeva O.A.
Published: November 2020

The lexical and grammatical aspects of direct and indirect speech in the Turkish news language were considered based on the materials from trustworthy Turkish online media, from which more than a hundred sentences containing direct and/or indirect speech were selected and analyzed. The following ways of introducing indirect speech were identified: predicate of indirect speech takes the form of verb noun -mA; predicate of indirect speech takes the forms -DIğI/-AcAğI; indirect speech is introduced as an extended participial phrase with semi-predicative meaning expressed by the participle of the present and past tense -An formed from verb of saying. Direct speech is formed: with the word diye; with the pronouns şu and şöyle; with a noun which forms a one-affix izafet (indefinite nominal compound) with direct speech and a verb. Combinations of direct and indirect speech in one sentence were as follows: indirect speech is formed with extended participial phrase expressing semi-predicative meaning, direct speech is formed with the word diye or nominal compound; indirect speech is in form of extended adverbial participial phrase with participle -ArAk, direct speech is formed with the word diye or nominal compound; indirect speech is in form of extended participial phrase expressing semi-predicative meaning, direct speech is formed with the pronouns şu and şöyle; indirect speech is in form of extended adverbial participial phrase with participle -ArAk, direct speech is formed with the pronouns şu and şöyle. The most frequent speech verbs were identified and classified into different lexical and semantic groups. They were analyzed in the context of co-occurrence with the verb noun -mA and the forms -DIğI/-AcAğI.
ASSISTIVE CLOTHING DESIGNS FOR MENTALLY RETARDED
Authors: Tuteja Shweta , Nigam Veena
Published: November 2020

Clothing has always been a kind of status symbol and expression of the individual personality. People wear clothing for functional as well as for social reasons. People of all ages and in all circumstances of life are aware of the importance of appearance in perception of self and in their relations with other people. However, for those whose surrounding environment is limited by age, condition of health, or physical and mental handicaps, dressing properly is a very difficult and impossible task. Therefore there is an urgent need to design clothing according to their special requirements. The aim of this study was to design and develop functional clothing for mentally retarded respondents. A questionnaire was developed for personal interview to assess clothing practices & problems of the disabled. The identified clothing requirements were incorporated in garment designs and finally constructed. After wear trial the designed and constructed garments were found to be highly acceptable.
TEACHER EFFICACY OF SECONDARY SCHOOL TEACHERS
Authors: Menon K.P Seema , K Sobha
Published: November 2020

The study aims to find out the teacher efficacy of secondary school teachers. The sample for the present study consisted of 350 secondary teachers of Kerala. In this study the investigators used a teacher Efficacy scale to measure the teacher efficacy of secondary school teachers. The study reveals that secondary school teachers possess an average level of teacher efficacy and also that  there exist significant difference in the mean scores of teacher efficacy with respect to type of management and teaching experience, but no significant difference exist in the mean scores of teacher efficacy with respect to Gender and locale and Subject of specialization.
Mr. Dharmaveer Bharti as essayist
Authors: Devi Pramila
Published: November 2020

The second Saptak edited by Agnayji Ji, the proponent of experimentalism, as early as 1951 AD. Dharamvir Bharti arrived in Hindi literature. Bharti ji is known as a novelist, storyteller, playwright, poet and editor of 'Dharmayuga'. Rich in this versatility, Bharti ji is also known as an eminent essayist.

While praising Dharamvir Bharti, Agyeya writes - "There are more talents, also more remarkable than others, but they have a specialty in Dharamvir Bharati." He is not only a good, hard working, interesting writer, he is the most original writer of a new plant.

प्रयोगवाद के प्रवत्र्तक अज्ञेय जी द्वारा संपादित ‘दूसरा सप्तक’ 1951 ई. के साथ ही डाॅ. धर्मवीर भारती का हिन्दी साहित्य में आगमन हुआ । भारती जी उपन्यासकार, कहानीकार, नाटककार, कवि और ‘धर्मयुग’ के संपादक के रूप में जाने जाते हैं । इस बहुमुखी प्रतिभा के धनी भारती जी को एक प्रख्यात निबंधकार के रूप में भी जाना जाता है । धर्मवीर भारती की प्रशंसा करते हुए अज्ञेय लिखते हैं - ‘‘प्रतिभाएॅं और भी हैं, कृतित्व औरों का भी उल्लेखनीय है, पर उनसे धर्मवीर भारती में एक विशेषता है । वे केवल अच्छे, परिश्रमी, रोचक लेखक नहीं हैं, वे नयी पौध के सबसे मौलिक लेखक हैं ।
THE TRANSMUTED GAMMA-GOMPERTZ DISTRIBUTION
Authors: AzZwideen Rwabi , Zou’bi Loai M. Al
Published: November 2020

This article introduces a four-parameter probability model which represents a gener- alization of the the Gamma-Gompertz distribution using the quadratic rank trans- mutation map. The proposed model is named the Transmuted Gamma-Gompertz distribution. We provide explicit expressions for its statistical properties, moment generating function, quantile function, the order statistics, the quantile function and the median. We estimate the parameters of the distribution using the maximum likelihood method of estimation.
The Analysis Impact of Bad News and Good News to Stock Return of State-Owned Banks Sebsector in Indonesia Period 2018
Authors: Surya Josephine , Andriana Isni , Umrie Rasyid HS
Published: November 2020

This study aims to determine and analyze the impact of bad news and good news on changes in stock returns of the four state-owned banks of Indonesia, period 2018. The population of this study is consists of four state-owned banks in Indonesia. Using a saturated sampling technique obtained four sample companies. Event study used to examine abnormal return around good news and bad news press release (announcement) date. The analysis technique used is Statistics Descriptive, One Sample Kolmogorov-Smirnov, Paired Sample T-Test, and Wilcoxon Sign Rank Test. There is no significant difference between before and after the press release of bad news. From ninety-six press releases of good news, five press releases showed there is a significant differences between before and after the press release of good news.
Social Media Capabilities dalam Adopsi Media Sosial Guna Meningkatkan Kinerja UMKM
Authors: Lina Lia Febria , Permatasari Berlintina
Published: November 2020

Social media is currently being used by both large companies and SMEs. For large companies the use of social media has been used successfully in reaching potential consumers. However, for SMEs, the marketing strategy of using social media is still being questioned. The purpose of this study is to fill the gaps in previous research by examining the driving factors for SMEs in using social media in promoting their products and testing how the performance of SMEs after adopting this technology is good both in financial and non-financial aspects that have not been done much research. The results of this study found that the compatible, cost-effective, interactive variables had a positive effect on the use of social media and subsequently had a positive effect on both financial and non-financial performance. However, the moderating role of social media capabilities cannot strengthen the relationship between use and the performance of SMEs. The results of this study are expected to be the basis for evaluating SMEs so that they can use digital media to support their business. The government must also pay attention to this to actively socialize the use of digital media for MSMEs so that the performance of SMEs can increase.
The Complexity Problem on the Law Enforcement by Indonesian Police Agency during the COVID-19 Pandemic
Authors: Hardiani Dwi Putri , Jaya Nyoman Serikat Putra
Published: November 2020

In Indonesia, the COVID-19 pandemic can be a fundamental concern if it is not able to overcome its impact. This pandemic considered to be very influential in affecting and disturbing several fundamental aspects of a country, such as health, economic, legal aspect, defense and security, and etc. This study examined the complexity problem of law enforcement by the police officer during the COVID-19 pandemic. The method of this researchusesnormative legal research by prioritizing secondary data that analyzed descriptive qualitative analysis techniques. The results of this study indicate that the police are referred to the law that lives in the community because of the work of the police plays an important role in maintaining the security and defense of the community, the law enforcement, as well as providing protection, protection, and services to the community. This has placed the police in dealing with various dynamics of social changing including the current COVID-19 pandemic. However, the problem with police law enforcement in the current COVID-19 pandemic arises from the implementation of Large-Scale Social Restrictions (PSBB) policy, the complexity problem in law enforcement on PSBB, and the choice to the possible solutions.
Teaching controversial issues in Religious Education: RE teachers’ attitudes and perceptions
Authors: RYMARZ RICHARD
Published: November 2020

Controversial issues in education have become more and more popular in recent years. Teachers themselves play a key role in their effective teaching, as they are the ones who are called upon to put into practice what the literature suggests in theory. This article explores the attitudes and perceptions of 33 Religious Education teachers on controversial issues, their competence (theological-pedagogical) and their concerns, regarding the teaching of controversial issues. The research was conducted in the context of two training meetings in September and October 2019, through a closed-ended questionnaire, based on the Likert rating scale. Data analysis was performed using the SPSS statistical package (version 25.0). The main conclusion is that teachers, although willing to apply the teaching of controversial issues in the classroom, nevertheless seem reluctant and uncertain about their professional and personal readiness. Therefore, the need to design a training framework for teachers, based on the model proposed by the Council of Europe on the teaching of controversial issues, emerges.
Erik Wetter and the genesis of the San Giovenale excavations
Authors: Tobin-Dodd Fredrik
Published: November 2020

The Swedish excavations at San Giovenale (1956–1965) had a major impact in the field of pre-Roman archaeology in Italy, primarily through the discovery of remains of both Etruscan and earlier domestic architecture. This article examines the genesis of the project, and suggests that the early history of the project has sometimes been misrepresented. While the excavations came to serve as a training-ground for young Swedish archaeologists and made very important contributions to the study of ancient domestic architecture, these were not explicit goals at the conception of the project. The article also studies the peculiar role of Admiral Erik Wetter in the San Giovenale excavations. Despite not being an archaeologist himself, Wetter was both the instigator and, in many ways, the driving force behind the project. The result was an unusual and unclear leadership situation, something that in the long run created problems for the project.
Effects of Individual and Coexisting Diabetes and Cardiomyopathy on Diastolic Function in Rats (Rattus norvegicus domestica)
Authors: Kitpipatkun Pitipat , Yairo Akira , Kato Konosuke , Matsuura Katsuhiro , Ma Danfu , Goya Seijirow , Uemura Akiko , Takahashi Ken , Tanaka Ryou
Published: November 2020

The goal of this study was to evaluate diastolic intraventricular pressure gradients (IVPG) and 2-dimensional tissue tracking (2DTT) patterns during diabetes and cardiomyopathy. Rats (n = 60) were induced to become diabetic (DM group, n = 15) by using streptozotocin, to
become cardiomyopathic (CM group, n = 15) by using isoproterenol, and to become both diabetic and cardiomyopathic (DMCM group, n = 15); control rats (CT group, n = 15) were injected with saline. Two months after induction, all rats underwent conventional echocardiography,
IVPG, and 2DTT and then were euthanized for microscopic examination of cardiac fibrosis. Compared with the controls, all 3 treated groups showed diastolic dysfunction and delayed cardiac relaxation. DMCM rats showed the most pronounced cardiac abnormalities. In addition, CM and DMCM groups
had showed decreased middle IVPG, whereas DMCM rats had decreased midapical IVPG. Although the overall IVPG of the CM group was normal, the middle segment was significantly decreased. 2DTT results showed that the DMCM group had a delay in relaxation compared with other groups. IVPG and 2DTT
can be used to overcome the limitation of conventional echocardiographic methods and reveal diastolic dysfunction. DM worsened diastolic function during cardiac disease.
PREFERENSI KOMUNIKASI PEMASARAN TERPADU PERGURUAN TINGGI DI SURABAYA PADA ERA POSMODEREN
Authors: Wono Hilda Yunita , Aji Imanuel Deny Krisna
Published: November 2020

This study aims to determine the activities of Integrated Marketing Communication (IMC) which is the preference of students at private universities X in Surabaya. This research is a quantitative type of research using the slovin method and stratified random sampling combined with purposive sampling as a sampling method. Existing data is processed using SPSS Statistics so that the data is presented in tabular form as data analysis. The results of this study were to find several IMC activities that were considered the most interesting by these college students, starting from the most popular ones namely sales promotion (42%) and followed by personal sales, and advertising. In this study also known some IMC activities that are considered unattractive or even unknown by students in this tertiary institution starting from those considered unattractive or unknown such as events and experiences (31%), then following with direct marketing activities, and finally is an advertisement where some unknown or uninterested students are found.
Is Malaysia ready for Industry 4.0? Issues and Challenges in Manufacturing Industry
Authors:   Faculty of Technology Management and Business,   Universiti Tun Hussein Onn Malaysia, Batu Pahat, 86400, MALAYSIA, Ling Yong Man , Abdul Hamid Nor Aziati ,   Faculty of Technology Management and Business,   Universiti Tun Hussein Onn Malaysia, Batu Pahat, 86400, MALAYSIA, Chuan Lee Te ,   Faculty of Technology Management and Business,   Universiti Tun Hussein Onn Malaysia, Batu Pahat, 86400, MALAYSIA
Published: November 2020

Despite as a strong manufacturing economist in ASEAN, manufacturers in Malaysia are the beginners who are lack of proper understanding of the concepts and practices of Industry 4.0. The purpose of this paper is to identify the issues and challenges of Industry 4.0 from industry-based companies' aspect by conducting a literature review. This paper also highlighted the comparison between the potential challenges stated in the Malaysia National Policy on Industry 4.0 with the challenges proposed by previous studies of other countries. This paper is a literature review on previous studies regards to challenges or issues on implementation of Industry 4.0 from 2015 to 2019. Total 11 challenges in the processes of implementation Industry 4.0 into manufacturing companies are reviewed. Compared to previous studies, Malaysia National Policy on Industry 4.0 overlooked 3 challenges on Industry 4.0. This is the first review paper to compare the existing challenges in Industry 4.0 with the potential challenges stated in the Malaysia National Policy on Industry 4.0.
Methods for evaluation of wheat breeding material for drought tolerance
Authors:   The V.M. Remeslo Myronivka Institute of Wheat, NAAS of Ukraine, Pykalo S. , Demydov O. ,   The V.M. Remeslo Myronivka Institute of Wheat, NAAS of Ukraine, Yurchenko T. ,   The V.M. Remeslo Myronivka Institute of Wheat, NAAS of Ukraine, Khomenko S. ,   The V.M. Remeslo Myronivka Institute of Wheat, NAAS of Ukraine, Humeniuk O. ,   The V.M. Remeslo Myronivka Institute of Wheat, NAAS of Ukraine, Kharchenko M. ,   The V.M. Remeslo Myronivka Institute of Wheat, NAAS of Ukraine, Prokopik N. ,   The V.M. Remeslo Myronivka Institute of Wheat, NAAS of Ukraine
Published: November 2020

Wheat is one of the most valuable cereals on the planet and plays a leading role in the food supply of mankind. The range of wheat is very large, since it is cultivated on five continents in most countries of the world. The genetic improvement of wheat is crucial because of its direct impact on the economic development, international grain trade and food security of the country, so the relevance of research in solving many genetic-breeding problems regarding this crop is growing and acquires a qualitatively new character. The increase in productivity is the most important criterion in the cultivation of any crops, in particular wheat. Drought is one of the main limiting environmental factors that reduce plant productivity. In order to guarantee agriculture from losses in dry years, it is necessary to have varieties tolerant to moisture deficiency. That is why one of the priority areas of wheat breeding is the creation of varieties tolerant to the action of water deficiency. The success of breeding when creating drought tolerant forms largely depends on the correct assessment of the degree of their tolerance. Conducting research on the assessment of genotypes for tole­rance to water stress is one of conditions for increasing efficiency of the breeding process of this culture. The results obtained in the analysis of literature data, found that for screening of wheat varieties for drought tolerance there are many methods based on different principles of action, and each of them has its advantages and disadvantages. To accelerate the breeding process and obtain reliable results, it is necessary to apply various methods of researching samples on specific signs of tolerance to stress. The choice of method largely depends on the degree of its complexity, the duration of the assessment and throughput. Therefore, the creation of new and improvement of existing methods for assessing wheat breeding material for drought tolerance in conditions of increasing water deficit or temperature increase will make it possible to objectively characterize the level of adaptability of promising genotypes and predict their behavior in appropriate environmental conditions.
Actual issues of hygienic regulation and creation of safe working conditions at pharmaceutical manufacturing enterprises
Authors: Vasilkevich Vadim M. , Bogdanov Ruslan V. , Drozdova Elena V.
Published: November 2020

Introduction. The working conditions of pharmaceutical industry workers are characterized by the combined effect of unfavorable factors of the production environment, among which the leading one is chemical. The aim of study is to substantiate the basic principles and criteria for hygienic regulation of pharmaceutical products in their production to ensure safe working conditions for employees based on the results of their own research and existing requirements of technical regulations. Materials and methods. Analysis of working conditions and the prevalence of health disorders in pharmaceutical workers (according to literature data), toxicological studies of pharmaceutical substances on laboratory animals, scientific justification of hygiene standards in the air of the working area. Results. Among employees of the pharmaceutical industry, the predominant forms of production-related health disorders are diseases of the respiratory system, as well as skin dermatitis of allergic origin, liver and biliary tract diseases. Based on the results of experimental studies of domestic pharmaceutical products for the treatment of cardiovascular, oncological and mental diseases that have priority socio-economic significance, the basic principles and features of the practice of justifying the hygienic standards of medicines in the air of the working area are developed and systematized. Conclusions. During hygienic rationing of medicines, it is necessary to use a differentiated approach that allows, based on the analysis of information about the chemical structure, physical and chemical characteristics, production conditions, pharmacotherapeutic activity, and the results of studying the toxic effect in an experiment on laboratory animals, to determine the maximum permissible content in the air of the working area of medicines or to justify the prohibition of isolation with reasoned recommendations for their safe production.
Occupational risk factors and physical condition of firefighters
Authors: Meshkov Nikolay A. , Bukhtiyarov Igor V. , Valtseva Elena A.
Published: November 2020

Firefighters are exposed to factors that can cause acute and chronic health problems and have long-term health effects. The study aim is to review and analyse publications by authors from Russia and abroad devoted to firefighting and health impacts of different risk factors. The authors analysed studies published on MedLine, PubMed, Elibrary.ru and Cyberleninka with data on working conditions, risk factors and health impacts for firefighters spanning different categories: those who work in cities, forest firefighters, and volunteers. The authors used statistical research methods for this analysis. Findings of the studies by Russian and foreign authors were used to analyse working conditions of firefighters, as well as trends, morbidity patterns and causes of newly diagnosed disabilities, and firefighter mortality compared to population of comparable age in Russia and other countries. The authors performed comparative analysis of risks of some diseases in firefighters and mortality caused by them. The authors found that respiratory diseases account for the largest cause of morbidity in firefighters in the area under analysis. Respiratory disease and musculoskeletal disorder risks are RR=2.8 (EF=65%) and RR=2.1 (EF=53%), respectively. Respiratory and circulatory system diseases are work-related diseases. Circulatory system diseases are the largest cause of inpatient care morbidity and disability in firefighters. According to several studies, cancer morbidity and mortality in firefighters has been increasing. Some studies say that the cancer mortality rate is higher in firefighters than in peer population, although others have not found such differences. Firefighters are exposed to occupational hazards and dangers, as well as to considerable psychological stress. Rates of disability caused by sensory system conditions, circulatory system diseases and digestive diseases are higher in EMERCOM of Russia’s firefighters than in other population groups. No relationship has been found between occupational risk factors and cancer morbidity in firefighters. Such a relationship can be confirmed only as a result of epidemiological studies.
Comparative analysis of polymorphic variants of IL-17A and MMP-1 genes with the risk of developing chronic periodontitis in petrochemical workers
Authors: Zaidullin Iskander I. , Karimov Denis O. , Karimova Lilija K. , Kabirova Milyausha F. , Galimova Rasima R. , Valeeva Elvira T.
Published: November 2020

The susceptibility to the development and progression of inflammatory periodontal diseases, which depends on genetic and external factors (smoking, stress, oral hygiene), varies widely. In the development of these diseases, an important role is played not only by the presence of periodontal pathogenic microorganisms, but also by the presence of congenital or acquired immunodeficiency, immunoregulatory defects. The immune system plays a key role in the physiological and pathological processes of periodontal tissues. In this regard, IL17, produced by CD4+ Th cells, which has both Pro-inflammatory and protective activity, is of particular interest in the pathogenesis of periodontitis. The aim of study was to identify the relationship between polymorphic loci of the IL-17A (rs2275913) and MMP-1 (rs1799750) genes and clinical manifestations of chronic periodontitis in petrochemical workers. Dental examination was performed in 92 ethylene oxide production workers with chronic periodontitis and 74 patients with chronic periodontitis who did not come into contact with chemical factors (control group). Genotyping of polymorphisms rs2275913 of the IL17A gene and rs1799750 of the MMP1 gene was performed by allele-specific real-time polymerase chain reaction (PCR). Hygienic assessment of the degree of air pollution of the working area with harmful substances was carried out by gas chromatography according to the guidelines for the determination of harmful substances in the air № 5098-89, № 3119-84. When comparing the results of studies of both groups, there were no statistically significant differences in the frequency distributions of allelic variants and genotypes of the IL-17A and MMP-1 genes. The AA/AG genotypes of the IL-17A gene were associated with an increased risk of severe disease compared to the GG genotype in workers in the main group (OR=6.1; 95% CI 1.33-28.5; p=0.021) and in the control group (OR=7.26; 95% CI 1.34-39.25; p=0.016). Carriers of the A allele in the control group increased the risk of severe chronic periodontitis by 2.4 times compared to carriers of the G allele (OR=2.41; 95% CI 1.19-4.87; p=0.014). During the dental examination of employees of the ethylene oxide plant, the clinical course of periodontal diseases was more severe in comparison with the control group, and the number of patients with severe periodontitis was twice as high. It was found that the AA/AG genotypes of the IL-17A gene and the carrier of the A allele are associated with increased susceptibility to the development of severe chronic periodontitis. The association between the MMP-1 gene polymorphism and the risk of severe forms of chronic periodontitis has not been established. A risk factor for the development of inflammatory periodontal diseases in employees of the petrochemical complex is a complex of harmful production factors.
The Use of ICT and its Effect on University Students’ Wellbeing During COVID-19.docx
Authors: Suárez Monzón Noemí , Cáceres Mesa Maritza Librada , Requeiro Almeida Reinaldo , Lara Paredes Diego Gudberto
Published: November 2020

Abstract

The COVID-19 pandemic has created an
unprecedented need for information and communication technology (ICT), which
has allowed university studies to continue in an online different environment, because
social isolation is compulsory. This article designed and validated an
instrument to assess the use of ICT and its effect on the wellbeing of Ecuadorian
university students. A theoretical framework was constructed based on
documentary analysis. A draft questionnaire considered students’ and experts’ suggestions.
A pilot questionnaire was then validated with a 1,952 students sample. Finally,
a reliability instrument was proposed that can be used in studies of similar
situations and is able to investigate the relationship between students'
wellbeing and ICT during the learning process. The questionnaire analysis
revealed that not all of the world’s educational systems are prepared to take
on the challenge of online classes, and not all students’ are equipped with conditions
needed to participate in online distance education.
SENAM BERSAMA KADER PKK
Authors: RAHMIATI
Published: November 2020

Senam dilakukan pada sore harioleh mahasiswa KKLP, ibu desadan masyarakat setempat. Senam di lakukan di halaman rumah kepala Desa.
The methyl CpG-binding protein MeCP2 is over-expressed in brain metastatic breast cancer.
Authors: Mamoor Shahan
Published: November 2020

Control of gene expression includes regulation by trans-acting transcription factors and cis-acting epigenetic regulation by chemical modification of histones and the DNA (1, 2). Brain metastases are a clinical problem in patients with breast cancer (3-5). We mined published microarray data (6-8) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the methyl CpG-binding protein MeCP2, a molecule with critical epigenetic functions in the brain (9, 10), was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. MeCP2 may be of relevance to the biology underlying metastasis to the brain, and it may be of relevance as a potential therapeutic target in patients with intractable disease.
Insomnia and post-traumatic stress disorder: A meta-analysis on prevalence and interrelated association
Authors: Ahmadi Reihaneh , Rahimi Sama , Javaheripour Nooshin , Emamian Farnoosh , Ghadami Mohammad Rasoul , Khazaie Habibolah , Zarei Mojtaba , Tahmasian Masoud , Sepehry Amir A.
Published: November 2020

Posttraumatic stress disorder (PTSD) is a common psychiatric disorder with several comorbidities (e.g., sleep disturbances). However, no convergent quantitative finding exists despite the well-documented link between PTSD and insomnia. Hence, a meta-analysis was conducted to examine the aggregate association and the magnitude of insomnia in PTSD. Here, we searched electronic medical search engines to identify studies reporting either the correlation or the prevalence of insomnia in PTSD. Forty studies met inclusion criteria and two aggregate effect size (ES) estimates were generated upon the correlations (K=18, comprising 5469 subjects) and the frequencies (K=16, comprising 5570392 subjects). A medium-size significant correlation was found [ES: 0.57 (CI: 0.49-0.63); n=5469], with a significant male sex effect [Slope: 0.0033; SE: 0.0017; P-value: 0.0446]. The prevalence of insomnia in PTSD was 48% [CI: 34-63; n ratio=1363384/5570392], and was moderated by insomnia and PTSD assessment scales, and diagnosis approach. This convergent perspective provides a better understanding of the association between insomnia and PTSD and warrants screening and better patient management.
Effects of blocked versus interleaved presentation on children’s vocabulary learning: A pilot study
Authors: Tan Li Ning Nicole , Bishop Dorothy Vera Margaret , Parker Adam James
Published: November 2020

In some educational contexts, it has been shown that interleaved presentation (i.e. alternating different tasks/skills) results in better learning than blocked presentation (i.e. practising one task/skill at a time). However, this interleaving effect has been studied in a limited range of contexts. Here, we examined whether blocked versus interleaved presentation influenced vocabulary learning in 56 children aged from 6 to 10 years old. We devised a novel online game involving two tasks. The first was a vocabulary learning task, in which children matched spoken words to images of novel animals. The second was a comprehension task, where the children arranged objects to match the spatial relations described in a spoken sentence. Stimuli were presented in a between-subjects design, such that trials from each task either occurred in blocks of 10 or were fully interleaved. Our analysis revealed vocabulary learning in both conditions, but the rate of learning did not differ for participants assigned to the blocked vs interleaved conditions. We did not, however, use posttest assessment means, so we cannot rule out any benefit of interleaving that may emerge after the initial learning phase.
Emotional learning retroactively enhances item memory but distorts source attributions
Authors: Hennings Augustin C. , Lewis-Peacock Jarrod , Dunsmoor Joseph E.
Published: November 2020

An adaptive memory system should prioritize select information surrounding a powerful learning event that may prove useful for predicting future meaningful events. The behavioral tagging hypothesis provides a mechanistic framework to interpret how weak experiences persist as durable memories through temporal association with a strong experience. Importantly, memories are composed of multiple elements, and different mnemonic aspects of the same experience may be uniquely affected by mechanisms that retroactively modulate weakly encoded memory. Here we investigated how emotional learning affects item and source memory for related events encoded close in time. Participants encoded trial-unique category exemplars before, during, and after Pavlovian fear conditioning. Results showed selective retroactive enhancements in 24-hour item memory were accompanied by a bias to misattribute items to the temporal context of fear conditioning. The strength of this source memory bias correlated with participants’ retroactive item memory enhancement, and source misattribution to the emotional context predicted whether items were remembered overall. In the framework of behavioral tagging: memory attribution was biased to the temporal context of the stronger event (fear conditioning) that provided the putative source of memory stabilization for the weaker event (non-emotional learning). We additionally found that fear conditioning selectively and retroactively enhanced stimulus typicality ratings for related items, and that stimulus typicality also predicted overall item memory. Collectively, these results provide new evidence that items related to an emotional event are misattributed to the temporal context of the emotional event and judged to be more representative of their semantic category. Both processes may help facilitate memory retrieval for related events encoded close in time.
Combating Bisexual Erasure: The Correspondence of Implicit and Explicit Sexual Identity
Authors: Kirby Teri Ann , Merritt Sally , Baillie Sarah , Malahy Lori Wu , Kaiser Cheryl
Published: November 2020

Both heterosexual and gay/lesbian individuals still question and erase bisexual identities. Skeptics contend that people adopt bisexual identities for strategic motivations, such as avoiding the stigma associated with identifying as gay or for attention-seeking purposes. Across two studies, self-identified gay (N = 168), straight (N = 237), and bisexual (N = 231) participants completed a sexual identity Implicit Association Test, a measure that can provide insight into automatic associations and lessen the influence of impression management strategies. All three groups displayed implicit sexual identities that were consistent with their self-ascribed identities. Gay men and lesbians implicitly identified as more gay and less bisexual than bisexual men and women, who in turn identified as less straight and more bisexual than straight men and women. These findings show that self-reported sexual identities converge with implicit identities and have implications for understanding the psychology of sexual orientation.
Efficiency in Sequential Testing: Comparing the Sequential Probability Ratio Test and the Sequential Bayes Factor Test
Authors: Stefan Angelika Marlene , Schönbrodt Felix D. , Evans Nathan J. , Wagenmakers Eric-Jan
Published: November 2020

In a sequential hypothesis test, the analyst checks at multiple steps during data collection whether sufficient evidence has accrued to make a decision about the tested hypotheses. As soon as sufficient information has been obtained, data collection is terminated. Here, we compare two sequential hypothesis testing procedures that have recently been proposed for use in psychological research: the Sequential Probability Ratio Test (SPRT; Schnuerch & Erdfelder, 2020) and the Sequential Bayes Factor Test (SBFT; Schönbrodt et al., 2017). We show that although the two methods have different philosophical roots, they share many similarities and can even be mathematically regarded as two instances of an overarching hypothesis testing framework. We demonstrate that the two methods use the same mechanisms for evidence monitoring and error control, and that differences in efficiency between the methods depend on the exact specification of the statistical models involved, as well as on the population truth. Our simulations indicate that when deciding on a sequential design within a unified sequential testing framework, researchers need to balance the needs of test efficiency, robustness against model misspecification, and appropriate uncertainty quantification. We provide guidance for navigating these design decisions based onindividual preferences and simulation-based design analyses.
Effectiveness of Progressive Muscle Relaxation in Reducing Depression, Anxiety and Stress among Haemodialysis Patients attending a Public Hospital at Central Java Indonesia
Authors: D Hudiyawati , A Muhlisin , Ibrahim Normala
Published: November 2020

The increasing trend of Chronic Kidney Disease (CKD) prevalence in Indonesia is a public health concern as it increases mortality, morbidity and burden of disease that has great implication on the health economic. In addition, CKD patients who are more likely to undergo hemodialysis is commonly associated with psychological problems such as depression, anxiety and stress and these have added more to the disease burden. Immediate measures such as progressive muscle relaxation (PMR) to reduce the psychological symptoms is of great importance before the symptoms progress into psychiatric disorders. The study was aimed to evaluate the effectiveness of PMR in reducing symptoms of depression, anxiety and stress among patients undergoing hemodialysis. It was a quasi-experimental, pretest-posttest control study that recruited 60 eligible respondents who underwent hemodialysis and was randomly allocated into intervention and waitlist control groups. Respondents in the intervention group performed PMR twice a day for two weeks. Mean scores of depression, anxiety and stress of respondents were examined before and after intervention using Depression, Anxiety and Stress Scale–21 questionnaire (DASS-21). Results showed that mean scores of depression, anxiety and stress differed significantly before and after intervention between groups and within the intervention group (p<0.05). PMR was effective to reduce the psychological symptoms among patients underwent hemodialysis. This highlight the importance to screen psychological symptoms among those patients and PMR should be taught to them as one of the stress-reducing measures.><0.005). PMR was effective to reduce the psychological symptoms among patients underwent hemodialysis. This highlight the importance to screen psychological symptoms among those patients and PMR should be taught to them as one of the stress-reducing measures.
Relationship between Voriconazole Concentration and Invasive Aspergillosis Treatment Outcome: Efficacy and Safety
Authors: C Puttilerpong , M Tantasawat , Ayudhya Panomvana Na , P Chantarit
Published: November 2020

Introduction: This study aimed to determine the association between the voriconazole (VRZ) concentration and clinical outcomes, including both the efficacy and safety in invasive aspergillosis (IA) treatment. Methods: The medical records of adult Thai patients with IA and treated with VRZ at the Ramathibodi Hospital, Thailand, between January 2013 and March 2016 were retrospectively reviewed, and their medical, social, demographic, laboratory data, VRZ dosage regimens and concentrations, and clinical outcome were recorded. The association between the VRZ concentration and clinical outcome was then determined. Results: A total of 81 patients were included in this study. Forty (49.4%) patients were male, with median age of 56.1 years. Sixty of them had hematologic malignancies. Forty-seven patients were diagnosed with probable IA. Median blood sampling time for VRZ level measurement was 11.5 h after the last dose administration on day 9. The median duration of treatment and outcome evaluation was 103 days and 73 days, respectively. Overall success and mortality rate were 76.5% and 14.8%, respectively. In the treatment success group, we found the success rate of around 90% with VRZ trough concentration (Ctr) of 3-4 mg/L. Eleven patients developed liver injuries (LI) and the rate of LI increased significantly with VRZ Ctr of more than 5 mg/L. Conclusion: We recommend VRZ trough concentration of 3-4 mg/L, as at this range the patients responded better to the treatment than at > 5.0 mg/L since it was associated with augmented hepatotoxicity.