bluuebunny/crossref_metadata_2025 huggingface dataset:
AID ACTIVITIES OF LODZ PARISHES BELONGING TO TWO CURRENTS OF CHRISTIANITY – CATHOLICISM AND EVANGELISM. SIMILARITIES AND DIFFERENCES
Authors: Korber Andy Christian
Published: June 2022

Charity and mercy, that is, selfless help to another person who is in need, are key concepts and commands in
Christianity. However, these ordinances apply not only to individuals, but also to the church institutions that constitute local
parishes at the lowest level of the organizational hierarchy. The largest religion in Poland in terms of the number of followers
is Christianity. Its biggest groups in relation to its followers are Catholics (almost 94% of the Poles) and Protestants (in various
factions, including almost a million Poles). Institutions belonging to both fractions carry out numerous aid activities on
a national scale. However, comparative research at the micro level, i.e. on the example of individual cities, is rarely undertaken.
The aim of the article is to characterize the aid activities carried out by parishes in Lodz belonging to two currents of
Christianity – Catholicism and Protestantism. In particular, I intend to show the differences in the aid activities of the two
denominations and determine their reasons.
Keharmonisan Pernikahan Dalam Perspektif Pengajaran Mempelai
Authors: Santosa Budi , Parinussa Stevanus , Waruwu Wenny Kristiani
Published: June 2022

Abstract: The phenomenon of marital disharmony is very varied. Busy work resulting in a lack of time and attention given to the family. Differences in financial income where when the wife has a salary greater than her husband, thereby reducing respect for her husband, and being an example for the children to their father. The existence of infidelity is also a trigger for the fracture of a marriage. Happy families must have a holy and harmonious marriage blessed by God. The purpose of establishing harmony in a family is not only the formation of a harmonious relationship between husband and wife, but also includes everything related to the welfare and peace of the family. This study uses descriptive qualitative methods with literature review to produce theoretical data on the concept of marital harmony as well as interview and documentation techniques to obtain concrete data about the concept of teaching the bride and groom. The results of the study show that: First, a harmonious Christian marriage will be achieved with the correct understanding and willingness to obey the authority of God's Word. Second, Christian marriage is very beautiful when husband and wife are able to realize and carry out their duties and functions proportionally. Third, the teaching of the bride and groom provides a starting point in marriage as a standard in the family and a picture of Christ's relationship with the church.
 
Abstrak: Fenomena ketidakharmonisan pernikahan sangat variatif penyebabnya. Kesibukan kerja sehingga kurangnya waktu dan perhatian yang diberikan bagi keluarga. Perbedaan pendapatan finansial dimana ketika isteri memiliki gaji lebih besar dari suami, sehingga mengurangi rasa hormat terhadap suami, dan menjadi contoh anak-anak kepada ayah mereka. Adanya perselingkuhan juga turut menjadi pemicu retaknya pernikahan. Keluarga bahagia harus memiliki pernikahan yang kudus dan harmonis diberkati Tuhan. Tujuan pembentukan keharmonisan dalam sebuah keluarga bukan hanya pembentukan hubungan harmonis suami isteri saja, tetapi didalamnya juga mencakup segala sesuatu yang berhubungan dengan kesejahteraan dan kedamaian keluarga. Penelitian ini menggunakan metode kualitatif deskriptif dengan kajian pustaka untuk menghasilkan data teoretis konsep keharmonisan pernikahan serta teknik wawancara dan dokumentasi guna memeroleh data konkrit tentang konsep pengajaran mempelai. Hasil penelitian menunjukan bahwa: Pertama, pernikahan Kristen harmonis akan tercapai dengan pemahaman yang benar dan kemauan untuk taat terhadap otoritas Firman Allah. Kedua, pernikahan Kristen sangat indah ketika suami isteri mampu menyadari dan menjalankan tugas dan fungsinya secara proporsional. Ketiga, pengajaran mempelai memberikan titik pijak dalam pernikahan sebagai standar dalam keluarga dan gambaran hubungan Kristus dengan jemaat.
Succession Planning Best Practices for Organizations: A Systematic Literature Review Approach
Authors: Bano Yasmeen , Omar Siti Sarah , Ismail Fadillah
Published: June 2022

Developing potential candidates for organizational sustainability and business continuity is a priority in any organization. Every organization is facing or will face challenges for the immediate future successor with the right people. Top management can create surroundings that allow leadership development with the help of internal succession planning. Succession planning is an enterprise approach that has gained a lot of interest in all organizations because of excessive demand for holding knowledge and the shortage of skilled workforce. The study was done by using the standard systematic literature review method. The current study focuses on providing a comprehensive review of best succession planning practices followed by all organizations. The major purpose is to describe the standard best practices of succession planning in any organization. This study will provide enough evidence to use succession planning as an instrument in the organisation's recruitment process, employee retention strategies, and future top management development within the organization
THỰC HÀNH VỀ DINH DƯỠNG VÀ MỘT SỐ YẾU TỐ LIÊN QUAN CỦA NGƯỜI BỆNH ĐÁI THÁO ĐƯỜNG TYPE 2 ĐIỀU TRỊ NGOẠI TRÚ TẠI BỆNH VIỆN ĐA KHOA ĐÔNG ANH, HÀ NỘI NĂM 2020
Authors: Đồng Thị Phương , Nguyễn Quang Dũng , Nguyễn Trọng Hưng
Published: June 2022

Thực hành dinh dưỡng có vai trò quan trọng trong điều trị và phòng ngừa biến chứng bệnh  đái tháo đường (ĐTĐ). Mục tiêu: Mô tả thực hành về dinh dưỡng và tìm hiểu một số yếu tố liên quan của người bệnh ĐTĐ type 2. Phương pháp: Nghiên cứu mô tả cắt ngang được tiến hành trên 440 người bệnh ngoại trú mắc ĐTĐ type 2 tại Bệnh viện Đa khoa Đông Anh–sử dụng phương pháp phỏng vấn bằng bộ câu hỏi thiết kế sẵn. Kết quả: Tỷ lệ thực hành tốt về dinh dưỡng của người bệnh là 37%. Người bệnh có trình độ từ cấp 3 trở lên có tỷ lệ thực hành tốt là 78,5% trong khi người bệnh có trình độ cấp 2 trở xuống là 18%. Tỷ lệ này ở đối tượng đã kết hôn so với đối tượng có tình trạng hôn nhân khác là 38,8% và 27,4%; ở người bệnh có thể trạng gầy–bình thường so với nhóm thừa cân–béo phì: 39,2 và 22,1%. Tỷ lệ này ở người bệnh được truyền thông về dinh dưỡng so với nhóm chưa từng nghe truyền thông là 41,7% và 23,1%. Kết luận: Thực hành tốt về dinh dưỡng của người bệnh ĐTĐ type 2 còn thấp, có mối liên quan giữa thực hành dinh dưỡng với trình độ học vấn, tình trạng hôn nhân, yếu tố truyền thông.
ỨNG DỤNG ENZYME PROTEASE LÀM TĂNG GIÁ TRỊ SINH HỌC CỦA PROTEIN TRONG CÁC SẢN PHẨM CHẾ BIẾN TỪ THỊT LỢN
Authors: Nguyễn Thị Phương Lan , Hoàng Thế Hưng
Published: June 2022

Protease là enzyme xúc tác thủy phân protein tạo thành những phân tử thấp và các amino axit. Nghiên cứu này cho thấy sử dụng Enzyme Protease (PRT-01/dạng bột) trong quá trình chế biến thịt lợn đã làm tăng giá trị sinh học, chất lượng cảm quan màu sắc, mùi vị của sản phẩm, đảm bảo sức khỏe cho người sử dụng, nhất là khi cường độ lao động tăng cao. Nghiên cứu khảo sát ảnh hưởng tỷ lệ, thời gian ướp enzyme protease trong quá trình chế biến. Kết quả thu được tỷ lệ enzyme protease 0,50%, thời gian ướp là 30 phút cho chất lượng cảm quan phù hợp nhất và hàm lượng 8 axit amin cần thiết tăng khoảng 2 lần so với sản phẩm chế biến từ thịt không được ướp enzyme.
Kodifikation und Demokratie
Authors: Hartmann Lucas
Published: June 2022

Die Entgegensetzung von Kodifikation und Demokratie als der Kontrast von systematischer und beständiger vs. kompromisshafter und reversibler Rechtsetzung ist überzeichnet und einseitig. Basierend auf einer Weiterentwicklung der Argumentationsmuster in Kodifikationsdiskursen lässt sich das Verhältnis von Kodifikation und Demokratie vielmehr differenzierter bestimmen: auf der Idealebene als Nebeneinander zweier über Selbststand verfügender Ideale, auf der rechtspolitischen Ebene - je nach der konkreten Gesetzgebungssituation - als Mit- oder Gegeneinander.
Unsichtbare Hermeneutiken: Die schwierige Wahlverwandtschaft von Rechts- und Wirtschaftswissenschaften
Authors: Hamann Hanjo
Published: June 2022

In den Geisteswissenschaften gerät die „Hermeneutik unter Verdacht“, wie der Titel eines neueren Sammelbandes suggeriert. Welcher Verdacht ist das, und wie steht es um die juristische und ökonomische Hermeneutik in Forschung und Lehre? Diesen Fragen widmete sich im vergangenen Herbst der hier dokumentierte Akademievortrag.
Selection and Role of Polymers for Designing of a Drug Carrier
Authors: Sharma Pankaj , Jain Vinay , Tailang Mukul
Published: June 2022

Polymers have helped to develop drug carrier technologies by allowing for the regulated release of bioactive molecules in consistent dosages over extended periods of time, cyclic dosing, and adjustable delivery of both hydrophobic and hydrophilic medicines. Formulations are released in a coordinated and consistent fashion over long periods of time. Polymers going to act as just an inert carrier whereby a substance can be conjugated having significant advantages. For instance, the polymer enhances the pharmacodynamic and pharmacokinetic characteristics of biopharmaceuticals in a variety of ways, such as plasma half-life, reduces immunogenicity, increases biopharmaceutical consistency, enhances the solubilization of low-molecular-weight substances, and has the prospects for targeted delivery. Smart polymeric delivery systems, in instance, have been investigated as “smart” delivery methods capable of releasing encapsulated pharmaceuticals at the right time and place of activity with respect to certain physiological stimuli. The development of novel polymeric materials and cross-linkers that are more biocompatible and biodegradable would expand and improve present uses. Polymer sensitivity to a particular stimulus may be tuned within a limited range because of the diversity of polymer substrates and their sequential production. The methods through which polymer frameworks are formed in situ to construct implanted systems for continuous release of medicinal macromolecules are discussed in this chapter, as well as numerous applicability of enhanced drug delivery.
Significance of “Quality Control” in Leather Goods and Garment Production
Authors: Hebo Abduletif
Published: June 2022

The leather industry is one of the priority sectors that contribute to export income and economic development in the majority of African countries, in terms of creating job opportunities. Leather products need high care during manufacturing because their quality should never be compromised. Quality is a universal term used to evaluate the performance of a product or a service and the acceptance by the customer(s) in terms of customer satisfaction. As such, understanding quality concepts such as quality control (QC), quality standards, procedures, and documents related to leather goods and garment production in accordance with manufacturing company’s policy is deemed useful within the context of this paper. Supervisors, quality controllers, and operators in leather products manufacturing firms need to know required quality parameters and associated control mechanisms so that defect-free products will reach the end users. In order to achieve this, quality-influencing parameters such as performance, reliability, durability, serviceability, esthetics, features, and conformance are measured so as to verify set quality levels. Furthermore, factors that affect the quality of leather goods and garments as well as methods of identifying and isolating common defects and faulty pieces especially in the finishing activities of leather production are included herein. Hence, this paper covers quality control aspects on leather goods observed within the garment manufacturing subsector.
Temperature Dependence of the Stress Due to Additives in KCl Single Crystals
Authors: Kohzuki Yohichi
Published: June 2022

The influence of the state of additive cations on the various deformation characteristics was studied for KCl:Sr2+ single crystal at room temperature. This result gives the heat treatment suitable for the crystal immediately before deformation tests, such as compression and tension. Four kinds of single crystals (KCl: Mg2+, Ca2+, Sr2+ or Ba2+) were plastically deformed by compression at 77 to room temperature. The plasticity of the crystal depends on dislocation motion from a microscopic viewpoint. When a dislocation breaks away from the defect around the additive cation with the help of thermal activation on the slip plane in the crystal, the variation of effective stress with the temperature was investigated by the combination method of strain-rate cycling tests and ultrasonic oscillations. Furthermore, the critical temperature Tc at which the effective stress due to the additives is zero was estimated for each of the crystals. As a result, Tc value tends to be larger with the divalent cationic size.
Volumetric and Dosimetric Inconstancy of Parotid Glands and Tumor in Head and Neck Cancer during IMRT
Authors: Gupta Seema , Srivastava Shraddha , Singh Navin , Ghosh Arunima
Published: June 2022

The treatment of head and neck cancer using external beam radiotherapy is commonly done with three field techniques, which involves bilateral parallel opposed beams and one anterior lower neck field. Conventional treatment is based on 2D fluoroscopic images where there is no facility to shield the organs at risk like parotid. The most common side effect of such conventional radiotherapy treatment is xerostomia. The incidence of radiotherapy-related xerostomia varies depending on the specific radiotherapy technique used and the dose delivered to the parotid glands. Dosimetric variation in the tumor and normal tissue including parotid glands due to volume shrinkage during intensity modulated radiotherapy is the leading challenges in radiotherapy delivery in head and neck malignancy in terms of acute and late radiation related toxicities. Therefore if the planning target volume and normal tissue anatomy are changing with time during intensity modulated radiotherapy, it would be beneficial and acceptable to adapt our treatment delivery to minimize normal tissue toxicities where it really matters.
Perspective Chapter: Interferon-Gamma in Natural Defence and Prevention of Leprosy
Authors: Santra Pragya , Ghosh Prama , Ghosh Soumyadeep , Behera Anwesha , Mitra Oyendrilla , Das Sharma Ishanee , Adhikary Diya , Banerjee Asesh , Gupta Prabuddha
Published: June 2022

Mycobacterium leprae causes leprosy. M. leprae enters the body through the upper respiratory tract where it interacts with host’s cells. Interferon (IFN) is a class of cytokines in human body that are released in case of viral and intracellular pathogen infection and they activate the immune cells to eradicate those pathogens. IFN-γ (Type-II IFN) confers immunity against bacterial, viral, and protozoan diseases. Loss of function mutations in IFN-γ results in poor immunity towards mildly virulent mycobacterium. Upon M. leprae invasion, monocytes enter the site of infection and differentiates into macrophages. IFN-γ induces endothelial cells (EC) of the pathogenic micro-environment to cause monocyte differentiation into pro-inflammatory M1 macrophages for immediate antimicrobial activity. This differentiation is ceased in the absence of endothelial cells. M1 macrophages are clinically more active than anti-inflammatory M2 macrophages induced by resting EC. The former produced higher amounts of pro-inflammatory cytokines in response to the TLR2/1 ligand of M. leprae. The former also showed elevation of vitamin D-associated antimicrobial pathway genes, which are required to counter M. leprae. In addition, the former accumulates less oxidised LDL to prevent growth of M. leprae. Thus, advancement of IFN-γ research would help in the design of next-generation anti- leprosy therapeutics.
Magnetite Nanoparticles (Fe3O4) for Radio-Frequency and Microwave Applications
Authors: Lathiya Poonam , Wang Jing
Published: June 2022

The size and shape dependent tunable electromagnetic (EM) properties of magnetite – Fe3O4 nanoparticles makes them an attractive material for various future electronics and biomedical device applications such as tunable attenuators, miniaturized isolators and circulators, RF antennas, EM shielding, and biomedical implants etc. The strategic design of RF devices requires specific dielectric and magnetic properties according to the applications, which in turn depends on the size and shape of the particles. At nanoscale, iron oxide’s magnetic and dielectric properties are very different from its bulk properties and can be tuned and enhanced by utilizing different synthesis approaches. In this chapter, we summarize electromagnetic properties of magnetite (Fe3O4) nanomaterials such as, complex permeability, complex permittivity, magnetic and dielectric loss tangents, saturation magnetization, temperature dependence, and ferromagnetic resonance; and how these properties can be optimized by varying different synthesis parameters. Finally, Fe3O4 nanocomposites will be explored by using different synthesis approaches for implementation of RF and microwave applications and we will conclude the chapter with future recommendations.
Crystallization: Its Mechanisms and Pharmaceutical Applications
Authors: J.R. Lemmer Hendrik , Liebenberg Wilna
Published: June 2022

The crystallization of small-molecule drugs plays an important role in the pharmaceutical industry. Since many downstream industrial processes are heavily influenced by the crystalline properties of a drug, that is, crystal shape, size distribution, and polymorphic form, control over the crystallization process can facilitate manufacturing and testing. However, before the crystallization process can be controlled, an understanding of its underlying mechanisms is required. In this chapter, we will look at the thermodynamic driving force behind crystallization and how crystal nucleation and growth rates can be used to control the properties of the resulting crystals. Throughout the chapter, we give examples of how these control approaches can be applied in pharmaceutical research and industry to obtain crystals with desired properties. We then finish this chapter with a look at crystallization from the amorphous state, which differs from crystallization from solution and is a relevant topic in pharmaceutical sciences, since the preparation of an amorphous solid is a popular approach to enhancing the solubility of a drug.
Evaluating Similarities and Differences between Machine Learning and Traditional Statistical Modeling in Healthcare Analytics
Authors: Bennett Michele , J. Kleczyk Ewa , Hayes Karin , Mehta Rajesh
Published: June 2022

Data scientists and statisticians are often at odds when determining the best approaches and choosing between machine learning and statistical modeling to solve their analytical challenges and problem statements across industries. However, machine learning and statistical modeling are actually more closely related to each other rather than being on different sides of an analysis battleground. The decision on which approach to choose is often based on the problem at hand, expected outcome(s), real world application of the results and insights, as well as the availability and granularity of data for the analysis. Overall machine learning and statistical modeling are complementary techniques that are guided on similar mathematical principles, but leverage different tools to arrive at insights. Determining the best approach should consider the problem to be solved, empirical evidence and resulting hypothesis, data sources and their completeness, number of variables/data elements, assumptions, and expected outcomes such as the need for predictions or causality and reasoning. Experienced analysts and data scientists are often well versed in both types of approaches and their applications, hence use best suited tools for their analytical challenges. Due to the importance and relevance of the subject in the current analytics environment, this chapter will present an overview of each approach as well as outline their similarities and differences to provide the needed understanding when selecting the proper technique for problems at hand. Furthermore, the chapter will also provide examples of applications in the healthcare industry and outline how to decide which approach is best when analyzing healthcare data. Understanding of the best suited methodologies can help the healthcare industry to develop and apply advanced analytical tools to speed up the diagnostic and treatment processes as well as improve the quality of life for their patients.
Entero-Behcet: A Challenging Aspect of Behçet’s Disease
Authors: Allaoui Abire , Belabbess Fatima , Jabbouri Rajaa , Alaoui Fatim-Zahra , Naitelhou Abdelhamid
Published: June 2022

Behcet disease is a proteiform vasculitis, and it can have multiple presentations. One of these presentations is digestive involvement commonly known as entero-Behcet. It is a challenging presentation of Behcet disease, because of its similarity with other inflammatory digestive diseases, especially Crohn disease, which makes its diagnosis difficult and uncertain in many cases. It is also challenging to treat, and its treatment can go from corticosteroids and immunosuppressive therapy to biologics. The absence of a standardized protocol to treat patients can be confusing for practitioners treating entero-Behcet. This incites doctors treating entero-Behcet to have multidisciplinary meetings to discuss patients’ cases. This review will give an insight into pathophysiology, diagnosis, and management of entero-Behcet to help practitioners taking care of this challenging aspect of entero-Behcet.
Application of Tissue Culture Techniques to Improve the Productivity of Medicinal Secondary Products from Medicinal Plants
Authors: M. Hassanein Ahmed
Published: June 2022

The plant kingdom is considered the most important source of medicinal chemicals. In vitro culture techniques are being considered a promising alternative to traditional agricultural processes to improve medicinal plants multiplication and their production of pharmaceutical compounds. In this chapter, several in vitro culture strategies are discussed to improve secondary metabolites production, including (1) plant kingdom as a source of medicinal chemicals, (2) in vitro culture of medicinal plants, (3) culture media optimization, (4) application of suspension cell culture for production of secondary metabolites, (5) elicitation to enhance the productivity of the culture, (6) precursor intermediates feeding, (7) selection of high-yielding cell lines, (8) overexpression of genes that control the production of bioactive compounds, and (9) scale-up production. Also, challenges that hinder the in vitro culture of medicinal plants using different techniques and the use of those techniques to produce pharmaceutical compounds are discussed in this chapter, including (a) secondary metabolites toxicity, (b) low growth rate, (c) culture browning, (d) limitation in the application of transformation, (e) somaclonal variation, and (f) vitrification. Therefore, the principal objective of the current chapter was to shed light on the studies on some medicinal plants and the used protocols to overcome some difficulties in terms of in vitro propagation that maximize their economic values.
The Efficacy of Artificially Assembled Boulder Installations in Improving Migration Routes for Aquatic Animals
Authors: Yasuda Youichi , Fuchino Nozomi
Published: June 2022

Naturally assembled rocks can be found in the natural rivers with gravel beds, and assembled boulders with large-scale rocks are stable after many floods. This chapter focused on assembled rocks from the point of view of the stability of the structure during many floods and the preservation of the aquatic habitat under normal conditions. In renovated rivers, the installation of hydraulic structures may result in the degradation of the river bed, local scouring behind the structure, bank erosion due to floods, and obstacles in the aquatic migration routes of aquatic animals. A balance between the prevention of disasters and the preservation of aquatic habitats should be maintained. Artificially assembled boulders should be recommended for river engineering technology. Unfortunately, there is no information on the hydraulics of artificially assembled boulders or on the imbrication of boulders in any part of the world. This chapter presents experimental research on the hydraulics of assembled boulders under normal and flooding conditions. A shallow water flow was formed near the water side under normal conditions. The stability of the structure of assembled boulders was confirmed under flooding conditions. These findings were confirmed by field inspection.
Acute Decompensated Liver: When to Transplant?
Authors: Kumar Yadav Dipesh , Kumar Yadav Rajesh , Liang Tingbo
Published: June 2022

Currently, liver transplant (LT) is only the effective treatment for an acute decompensated liver. Yet, a result of LT in the background of acute decompensated liver largely depends upon the cause of decompensation. Acute-on-chronic liver failure (ACLF) should not be confused with acute liver failure (ALF), where a patient with ACLF presents with a distinct clinical feature than ALF and often requires LT as the only definitive treatment option. However, ACLF patients are generally not listed for the emergency LT due to advanced age, ongoing sepsis, multiple organ failures and active alcoholism. Then again, about 40% of the patients with ALF recover spontaneously with medical care and hence do not need LT. In between these all perplexities and contentions, it’s critical to comprehend the clinical course of liver failure. In addition, physicians should also understand when it is necessary to enlist a patient for LT and which patient are likely to get benefit from LT. Thus, utilizing a “golden window” time for LT before the development of multi-organ failure. In this chapter, we focus on the current situation of LT for ALF and ACLF and further discuss the current decision making strategies used to indicate LT in this difficult clinical scenario.
Risk factors for intensive care unit need in patients with COVID-19: An analysis of 368 cases
Authors: KOC Filiz , FİRAT GÖKTAS Emine , FİRAT Pinar , SESEN Zehra Nur , YİKİLGAN Aslı Burcu , DEMİRKALE İsmail , AKDUMAN Davut
Published: June 2022

Objective: Covid-19 is a global epidemic that predominantly affects the respiratory system, in which about 20% of patients are severe and about 10-15% of mild cases become severe. The clinical and laboratory findings in the course of the disease are mild in the first week and may become more severe in the following days, also the possibility false negativity of the tomography in the first 24-48 hours, making it difficult to select patients in triage. Being able to detect cases that may have a serious course in the Covid-19 pandemic will help health systems to function without interruption. In our study, we tried to identify cases that may need intensive care in triage.

Methods: Medical records and radiological findings of 368 patients with laboratory-confirmed Severe-Acute-Respiratory-Syndrome Coronavirus-2 infection who were hospitalized between March and June 2020 were reviewed. The patients were analyzed by dividing into two groups; group 1; critically ill patients with severe pneumonia who need intensive care during treatment. Approximately 8% of all patients are in this group. Group 2; non-critical patients who do not need intensive care followed in the clinic.

Results: It was determined that the mean age of the patients in Group 1, the rate of being over 50 years old and the male gender ratio were higher than Group 2.

Conclusion: Although there are low oxygen saturation, tachypnea and comorbid diseases in critically ill patients in triage, advanced age and male gender were found to be the most important risk factors for intensive care need.
Myelodisplastik Sendrom Tanılı Olguların Sitogenetik / Fish ve Demografik Verilerinin İncelenmesi
Authors: ŞEYHANLI Ahmet , EROGLU Muhammed , SOLMAZ Şerife , YÜCE Zeynep , ÖZKAL Sermin , ALTUNGÖZ Oğuz , ALACACIOĞLU İnci
Published: June 2022

Amaç: Myelodisplastik sendrom (MDS) kemik iliğinde anormal selüler proliferasyon, çevre kanında, bir veya daha fazla hücre dizisinde sitopeni, kemik iliğinde displazi ve akut myeloid lösemi (AML) gelişme riski ile karakterize heterojen bir hastalık grubudur. Bu çalışmanın amacı MDS hastalarında demografik veriler, konvansiyonel sitogenetik, Florasan in situ hibridizasyon (FİSH) ve prognostik özelliklerini değerlendirmektir.

Yöntemler: Bu çalışmaya Ocak 2010 - Ocak 2020 tarihleri arasında DEÜTF Hematoloji Bölümü’nde takip edilen 18 yaş ve üzerindeki MDS tanılı hastalar dahil edildi. Hastaların verileri geriye dönük arandı. Herhangi bir zamanda tanı alan hastaların hemogram, biyokimya, sitogenetik ve FİSH sonuçları, sağ kalımları, almış oldukları tedaviler, sitopeni dereceleri, kemik iliği blast yüzdeleri, kemik iliği biyopsi sonuçları incelendi.

Bulgular: Çalışmaya Ocak 2010-Ocak 2020 tarihleri arasında MDS tanısı almış ve izlemde olan 18 yaş ve üzerindeki 205 hasta alındı. Kadın/Erkek oranı 0,8/1 olarak bulundu. Ortanca yaş 70,7 (27-92) idi. Ortanca hemoglobin değeri 9,4 (4.8-14.5) idi. MDS olguları, 2016 Revize-WHO Sınıflaması’na göre sınıflandırıldıklarında; en fazla 78 hasta (%38) ile MDS-SLD grubunda saptandı. Konvansiyonel sitogenetik analiz yapılabilen 141 hastanın 112’sinde (%79,4) normal karyotip saptandı ve bu yöntem ile en fazla saptanan sitogenetik anomali komplex karyotipti (n=9, %6,3). FİSH paneli ile bakılan 135 hastanın genetik anomalilerine göre medyan sağkalımlarına bakıldı. FİSH sonucuna göre 7q delesyonu ve P53 mutasyonu olan hasta popülasyonlarında, mutasyon olmayan gruba göre azalmış ortanca sağkalım süreleri istatistiksel olarak anlamlı saptanmıştır (p-değeri
Çocuk Ailesel Akdeniz Ateşi Hastalarında MEFV Mutasyonlarının Dağılımı: Türkiye’nin Güneydoğusunda Tek Merkezli Çalışma
Authors: BİNİCİ Mahir , TEKEŞ Selahaddin , BALKAN Mahmut , ORAL Diclehan , YÜCEL İlyas , TUNÇ Şaban
Published: June 2022

Amaç: Ailevi Akdeniz Ateşi (FMF), Akdeniz'de yaşayan etnik gruplarda (Türkler, Araplar, Yahudiler ve Ermeniler) görülen resesif geçişli otoinflamatuvar bir hastalıktır. Farklı coğrafi bölgelerde ve etnik gruplarda FMF’ deki MEFV mutasyon değişimi farklılık göstermektedir. Bu çalışmada, son yıllara ait mutasyon dağılımını belirleyerek bölgemizdeki MEFV mutasyon dağılım verileri ile ülke geneli ve diğer bölgelerin mutasyon dağılımını karşılaştırmayı amaçladık.

Yöntemler: Merkezimize sevk edilen FMF klinik semptomları tespit edilen 286 hastanın moleküler test sonuçlarını değerlendirdik. Moleküler analiz için hastaların, pyrosequencing yöntemi kullanılarak MEFV genindeki 22 yaygın mutasyon analizi yapıldı.

Bulgular: 286 hastanın genetik analizi sonucu; 74 (%25,87) hastanın 27’sinin homozigot (%9,44),47’ sinin bileşik heterozigot (%16,44) mutasyona sahip olduğunu, 212'sinin (%74,13) isesadece tek bir mutasyon taşıdığını ortaya koydu. Allel frekansları göz önüne alındığında en yaygın mutasyonlar; E148Q (%32,50), M694V (%26,94), V726A (%10,83), R761H (%10,83), M680I (G>C) (%6,11) ve P369S (%5,56) şeklindedir.

Sonuç: Bu tek merkezli çalışmada, Türkiye'nin güneydoğusundaki çocuk FMF hastalarından elde edilen yaygın MEFV gen mutasyonlarının sıklıkları hakkında bilgi verdik. Hastaların yaklaşık yarısı alellerinde en az bir E148Q veya M694V mutasyonu taşıyordu. Bölgemizdeki verileri ülke geneli ve Ege bölgesi ile karşılaştırdığımızda en sık rastlanan mutasyon açısından farklılıklar olduğu gözlenmektedir. Çalışma sonuçlarımız ülkemizin Güneydoğu Anadolu Bölgesinde yapılan önceki çalışmalarla karşılaştırıldığında, mutasyon oranları arasında farklılıklar olduğu gözlemlenmektedir. Bu çalışmayla bölgemizdeki FMF hastalarının mutasyon dağılımlarının güncel verileri elde edilerek literatüre katkıda bulunulmuştur.
How to Be a Spacetime Substantivalist
Authors: Teitel Trevor ,   Journal of Philosophy Inc.
Published: June 2022

The consensus among spacetime substantivalists is to respond to Leibniz’s classic shift arguments, and their contemporary incarnation in the form of the hole argument, by pruning the allegedly problematic metaphysical possibilities that generate these arguments. Some substantivalists do so by directly appealing to a modal doctrine akin to anti-haecceitism. Other substantivalists do so by appealing to an underlying hyperintensional doctrine that implies some such modal doctrine. My first aim in this paper is to pose a challenge for all extant forms of this consensus position. My second aim is to show what form substantivalism must take in order to uphold the consensus while addressing this challenge. The result is a novel “plenitudinous” substantivalist view, which predicts that certain modal facts about spacetime are vague or indeterminate. I then argue against this view on independent grounds, concluding that substantivalists should reject the consensus position. The paper also discusses the way forward for substantivalists in light of this conclusion.
Formulating Moral Error Theory
Authors: Perl Caleb ,   Journal of Philosophy Inc.
Published: June 2022

This paper shows how to formulate moral error theories given a contextualist semantics like the one that Angelika Kratzer pioneered, answering the concerns that Christine Tiefensee developed.
Sisubiotus hakaiensis sp. nov. (Tardigrada, Macrobiotidae), a new tardigrade species from Calvert Island (British Columbia, Canada)
Authors: Vecchi Matteo , Choong Henry , Calhim Sara
Published: June 2022

Tardigrades reports from British Columbia (Canada) trace back to 1908 and numerous species have been recorded from this region, despite the relatively few published sampling studies. We describe by integrative taxonomy (light microscopy morphology, morphometrics, and DNA sequencing) a new tardigrade species, Sisubiotus hakaiensis sp. nov. from the British Columbia central coast. The new species has been found in moss collected from a vertical rock outcrop near the Hakai Institute Calvert Island Field Station. Sisubiotus hakaiensis sp. nov. differs from all the other known species in the genus by the presence of a labyrinthine layer inside the egg process walls, whereas no consistent differences in the animals were found. This unique egg characteristic therefore required the amendment of the Sisubiotus generic diagnosis to account for the presence of the labyrinthine layer inside the egg process walls.
Educação pós-Auschwitz: implicações de um texto clássico
Authors: Barros José D'Assunção
Published: June 2022

Um dos mais célebres textos sobre os riscos da presença do fascismo nas sociedades contemporâneas foi o célebre Educação Pós-Auschwitz – inicialmente proferido por Theodor Adorno como palestra, em 18 de abril de 1965, e pouco depois publicado como artigo em Frankfurt (1967). Este texto recoloca o conceito de fascismo em uma nova escala, afastando-se da conceituação histórica do fascismo mas permitindo avançar em uma compreensão sobre a permanência de comportamentos que podem ser ditos como fascistas nas sociedades contemporâneas. Neste artigo, pretendemos revisitar essa discussão lançada por Adorno, a partir deste texto clássico, cotejando-o eventualmente com outros textos e acrescentando exemplos históricos posteriores a ele, como o massacre de tutsis em Ruanda, em 1994. Nos tempos atuais, em que os comportamentos fascistas parecem aflorar em muitos momentos, a rediscussão deste texto clássico sobre o fascismo mostra-se oportuna.
A revista por ela mesma e o revistativo: problematizações sobre um modo de ser jornalismo
Authors: De Mello Brandão Tavares Frederico
Published: June 2022

Apesar de recorrente em pesquisas no campo científico, a revista carece de problematizações que mobilizem perguntas acerca de suas particularidades. Nesse sentido, este artigo, revisitando um texto publicado anteriormente, pretende discutir o jornalismo de revista como um objeto de estudo, acionando teorias e tensionando conceitos que visam a complexificar sua presença nos estudos comunicacionais, jornalísticos e editoriais. O argumento principal orienta-se pelo questionamento da revista como um problema de pesquisa, relacionando autores que tratam das especificidades deste produto editorial e comunicativo, bem como do jornalismo por ele configurado. Finalizando este trajeto, propõe-se pensar a revista a partir de conceitos que, terminológica e teoricamente, pretendem oferecer subsídios para reflexões que coloquem a revista no centro de uma problemática investigativa.
Jornalismo e diversidade: vozes na Revista Exame
Authors: Baldissera Rudimar , Vinhola Bruno , Almeida Charles Florczak , Carvalho Douglas Elias
Published: June 2022

Neste trabalho objetivamos evidenciar as vozes conformadoras do discurso da revista Exame sobre diversidade e compreender como elas são acionadas para instituir concepções que realizam uma captura gerencial desse tema. Após apreciação das edições publicadas pela Exame em 2019, identificamos 26 matérias que fazem alguma referência à diversidade, as quais foram selecionadas para compor o corpus de análise. Partindo de aportes teóricos sobre diversidade e gestão, jornalismo de revista e teoria do discurso, realizamos um estudo das vozes pela trilha da análise do discurso. As principais inferências são as de que, a despeito do acionamento de múltiplas vozes, inclusive as de grupos minorizados, materializa-se um discurso predominantemente monofônico, o qual, ainda que se proponha polifônico, tende a reafirmar um ideário organizacional preestabelecido.
UMA REVISÃO DE LITERATURA SOBRE SOFTWARES UTILIZADOS EM ESTUDOS DE AVALIAÇÃO DO CICLO DE VIDA
Authors: Campolina Juliana Mendes , Sigrist Carolina São Leandro , Moris Virgínia Aparecida da Silva
Published: June 2022

A Avaliação do Ciclo de Vida (ACV) é uma ferramenta de gestão ambiental utilizada para determinar o impacto ambiental de um produto, processo ou serviço durante seu ciclo de vida a partir do levantamento de dados, em especial na fase do Inventário do Ciclo de Vida (ICV). Existe uma grande variedade de softwares disponíveis no mercado para auxiliar nesses estudos, e considerando a facilidade que os mesmos e o banco de dados proporcionam para ACV, o presente estudo realiza uma revisão de literatura sobre o assunto. Pela análise da literatura, verificou-se que os softwares possuem diversos métodos de análises de impactos e banco de dados de processos, possibilitando a comparação de cenários. Os resultados obtidos com os softwares são a análise de impactos e interpretação dos resultados do sistema, apresentando os mesmos através de gráficos, fluxogramas e tabelas. Os softwares disponibilizam banco de dados que possuem informações sobre o ciclo de vida de produtos gerando uma redução no tempo de coleta de informações, porém deve-se lembrar que os banco de dados possuem caráter regional e seus dados devem ser analisados, pois o conjunto de dados de um banco de dados pode não cobrir exatamente o sistema estudado, afetando os resultados.
ANÁLISE DA APLICAÇÃO DE INVESTIMENTOS EM PERDAS DE ÁGUA NO NORDESTE BRASILEIRO
Authors: Cambrainha Géssika Maria Gama , Fontana Marcele Elisa
Published: June 2022

A situação do saneamento em todo Brasil é considerada calamitosa. Em decorrência das características geográficas da região Nordeste, a água encontrada nesse estado precisa ser aproveitada ao máximo. Uma das maneiras de atingir esse objetivo é através do controle das perdas de água. O presente estudo objetivou avaliar o quanto dos investimentos no setor de água é refletido na redução das perdas. Mais especificamente os objetivos Foram: (1) Levantar informações de investimentos e perdas no setor de recursos hídricos da região Nordeste; (2) Realizar diagnóstico das perdas de água na região Nordeste; (3) Efetuar análise estatística dos dados. Com o exame dos altos índices de perda, fica evidente que o aumento dos investimentos em grandes obras para uma maior captação de recursos hídricos é o foco das companhias, enquanto que, a devida gestão das perdas, com a qual os estados do nordeste poderiam evitar a constante dependência do clima, não é ainda tratada como objetivo principal.
ARBORIZAÇÃO E JARDINAGEM NA ESCOLA MUNICIPAL DE ENSINO FUNDAMENTAL ASSIS BRASIL EM PALMEIRA DAS MISSÕES – RS
Authors: Fagundes Joice Feil , Bandeira Giseli Luisa , Siqueira André Boccasius , Neis Franciele Antonia , Konflanz Tais Lazzari
Published: June 2022

O intuito deste projeto foi sensibilizar e motivar crianças/alunos da Escola Municipal Assis Brasil, localizada no município de Palmeira das Missões/RS, a trabalhar em equipe, preservar e organizar o espaço escolar. A problemática girou em torno da melhoria da qualidade ambiental do espaço frequentado pelos alunos e, por isso, o trabalho de arborização e jardinagem no exterior da escola teve como finalidade deixar o local agradável e recreativo, já que em boa parte do tempo os alunos permanecem nesse espaço. Para que a comunidade escolar possa ter melhor harmonia com o ambiente natural é fundamental que haja um espaço organizado e esteticamente agradável. Portanto, é importante desenvolver projetos para criar um ambiente adequado e aconchegante, sendo dever da comunidade escolar preparar cidadãos para uma vida social humanizada e harmonizada com o meio ambiente.
An experimental study of the influence of spike in supersonic and transonic flows past a hemispheric body
Authors: Milićev Snežana
Published: June 2022

A strong shock wave during a supersonic flight of a blunt-nosed projectile increases the drag and aerodynamic heating considerably. A spike can be mounted on the nose of the projectile to reduce these effects. Apart from its very existence and its length, the spike's shape may also affect the aerodynamic characteristics of a blunt body. This paper presents the results of an experiment that analyzed the influence of the spike's shape on the aerodynamic forces and moments coefficients, and the location of the center of pressure, at supersonic and transonic flows past a model of a projectile with a hemispheric forebody. The experiment was carried out in a trisonic wind tunnel, for Mach numbers M=1.89 and M=1.03 and different angles of attack (0○ -10○ ). Visualization of the experiments was performed by the schlieren method in the case of supersonic flow. It enables qualitative analysis of the airflow around the tested model without and with four different spikes. The conclusions are by the obtained values of the aerodynamic coefficients. The experiments show that a spike and its shape affect only the performance of the tested projectile during its supersonic flight. Besides, a spike does not affect or even slightly impairs the aerodynamic performance of the projectile during its transonic flight. The obtained results are applicable in broader contexts, e.g. for the design of an aircraft for supersonic flights.
Application of Paris' law under variable loading
Authors: Bulatović Srđan , Aleksić Vujadin , Milović Ljubica , Zečević Bojana
Published: June 2022

The most important characteristics for service safety of welded joints are those describing crack initiation and growth caused by variable loading. Crack initiation and growth caused by variable loading is the subject of numerous investigations. This paper shows the determination of parameters of the fatigue crack for constituents of welded joints produced of high strength low alloyed steel. The crack growth law of Paris establishes the relation between the applied variable load quantity or the corresponding stress intensity factor range and crack growth per cycle. Results have shown that the position of the notch and crack initiation affect the values of the stress intensity range of fatigue threshold DKth and parameters in the Paris' equation.
Mathematical and computer simulation for the appearance of dimple defect by cold combined extrusion
Authors: Hrudkina Natalia , Markov Oleg , Shapoval Alexander , Titov Viacheslav , Aliiev Igramotdin , Abhari Payman , Malii Khrystyna
Published: June 2022

The article is considered a comparative analysis for predicting defect such as dimple by energy method of power balance, upper bound method and finite element method. The upper bound method takes into account the geometrical position and dimension of the dimple, the criterion for the formation in dimple by energy method of power balance is the presence of a minimum point in the function of relative pressure on the relative velocity of metal outflow in the vertical direction. New engineering calculations for the relative pressure are developed in combined radialbackward extrusion process by using a kinematic module with fillet. A comparative analysis of the obtained data has been carried out by energy method of power balance, upper bound method, computer simulation by Qform 2/3D program and experimental data. Rationality of using the energy method of power balance in view of its efficiency and the possibility of taking into account various friction conditions and the presence of fillet on the matrix, as well as smaller deviations from the results of finite element simulation and experimental data have been defined. Providing more conditions that are favorable for friction in the bottom of the billet and in the flange area in comparison with the friction conditions on the glass wall contribute to delay in the dimple appearance. It was found that the radius of fillet makes it possible to delay the dimple appearance by the approximately (0,4 ÷ 0.5R) mm for the entered radius of fillet R. This allows us to expand the possibilities of obtaining parts with a flange by combined radial-backward extrusion without the formation of a defect such as dimple.
Adaptive assembly module for industrial robot: Design and simulation
Authors: Polishchuk M. , Telenyk S. , Tkach M.
Published: June 2022

In modern production, automation of assembly processes is achieved by using industrial robots with high positioning accuracy, as well as with elements of tactile adaptation and expensive software. The article proposes an alternative approach to solving the problem of reducing the cost of assembly processes. This approach consists of using production tooling in the form of a soft adaptive assembly module that is mounted on the robot arm. The proposed assembly module allows not only for compensating for errors in the relative orientation of assembly objects, but also excludes the possibility of damage to fragile assembly components or for assembly objects with a thin protective coating of a chemical or galvanic nature. This effect is achieved due to the use of elastic corrugated chambers in the module structure, which, when compressed air is supplied to them, correct the position of one of the assembly objects. The article offers a description of the new design of the assembly module, as well as offers analytical dependencies for calculating the design parameters of the module. The results of modeling the parameters of the assembly module are presented. The main economic effect is to reduce the cost of technological equipment for industrial robots while maintaining the ability to adapt to the conditions of the assembly process.