bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving the efficiency and safety of hardening filling mixtures pipeline transport to deep mines
Authors:   State Enterprise Ukrainian Research and Design Institute for Industrial Technology, Liashenko Vasilii , Franchuk Vsevolod ,   National Mining University
Published: February 2021

Relevance. Extraction of mineral raw materials has a negative impact on the natural environment. This effect is neutralized through technologies for mineral extraction using various options for development systems with worked-out spaces filling with hardening filling mixtures of various composition and strength. However, their application is complicated by hardening filling mixtures transportation through the pipeline over considerable distances vertically and horizontally to the point of placement, increased material and labor costs, and a shortage of material for preparing mixtures. Research aim is to improve the efficiency and safety of hardening backfill mixtures pipeline transportation into deep mines by determining the main parameters of hardening backfill mixture pipeline transportation installations (PTI), based on the conditions of its reliable delivery to the point of placement at minimal costs. Research methodology included literature review, the methods of theoretical generalizations using mathematical statistics, physical and mathematical modeling, calculations and feasibility studies, laboratory and field experimental studies, and industrial tests in deep mines using standard and new methods. Results. New USD-1 equipment has been developed and put into production for hardening filling mixtures delivery to deep mines; the equipment ensures overpressure reduction in the pipeline installed in the rise heading of 895–825 m floor in the Novaya-Glubokaya mine, Zheltye Vody, Ukraine. Conclusions. The recommended value of the maximum length of the pipeline between the reloading nodes is within the range of 415–508 m, and the excess of the emergency unloading point above the horizon is 11 m. In the last section of the vertical pipeline (turning into horizontal), a length is selected that ensures normal transportation of the mixture. The efficiency of hardening backfill mixture transportation has been established, which increases due to the elimination of stratification in the horizontal section of the pipeline under the condition of vmin <v <vmax, where v, vmin, vmax are mixture velocities corresponding to the steady design mode of transportation, the presence of solid aggregate particles at the limit in the weighted condition and maximum filling level of the filling pipeline vertical column.
Mining sciences in the branch of Earth sciences
Authors:   Institute of Mining UB RAS, Iakovlev Viktor
Published: February 2021

Problem statement. What is mining science? Is it craft, art of “treasure hunters”, or science? What underlies the theory of mineral extraction? What is its place within the system of knowledge of the environment? Discussion. Today there is no precise, clear, and conventional definition of mining science, its matter and object. Certain attempts by numerous leading mining experts to become involved in the discussion 14 "Izvestiya vysshikh uchebnykh zavedenii. Gornyi zhurnal". No. 1. 2021 ISSN 0536-1028 extended significantly the range of applied problems, but generally the problem hasn’t been fully shaped. The ideology of the market is pragmatic (goods-money-goods), while the ideology of science is radiant as soon as it tries to cognize something unbounded. Obvious practical focus of mining historically convinces us of the fact that the mining effectiveness and wide knowledge of the interior, rock properties, law and forms of labor management are inextricably linked. Summary. Mining science should take rightful place among Earth sciences not only because mining is a stimulus to civilization, but also due to a range of life-support problems which mining knowledge deals with.
The Role of Media in Consumption under “Attention Economies”: A Study Based on the Interviews of Chinese Postgraduates towards the M&M’s Advertisements
Authors:   Department of Communication, Faculty of Modern Languages and Communication, Universiti Putra Malaysia, Xie Yuting , Yasin Megat Al Imran Bin ,   Department of Communication, Faculty of Modern Languages and Communication, Universiti Putra Malaysia., Alsagoff Syed Agil ,   Department of Communication, Faculty of Modern Languages and Communication, Universiti Putra Malaysia, Ang Lay Hoon ,   Department of Foreign Languages, Faculty of Modern Languages and Communication, Universiti Putra Malaysia.
Published: February 2021

The rapid development of media in the world promote the prosperity of the economy to a certain degree. Advertisement, as one of communication form of mass media, gradually becoming one of an important part in the attention economy. In view of these, the research chooses M&M’s advertisements as examples to discover what factors attract audiences’ attention and then lead to consumption, and how they play their role during the process. Three methods are employed in this research: in-depth interview, observation and textual analysis. Five Chinese postgraduate students are selected as objects, and they answer the questions by the researcher after they watched two types of M&M’s advertisements (celebrity-based advertisement and content-based advertisement). Through the combination of interview, it can be found that both celebrities, memory and social media platform can exert their role in the attention economy. This article also expects to offer a reference for advertisers and product manufacturers, helping them adjust their marketing strategies rationally by using celebrities and other elements.
Introducing an economic agricultural water distribution in a hyper-arid region: a case study in Iran
Authors: Khiabani Mehdi Yaltaghian , Shahdany Seied Mehdy Hashemy , Hassani Yousef , Maestre Jose M.
Published: February 2021

Operational management of agricultural water based on an economic perspective was investigated as a sustainable approach in water shortage periods. Accordingly, an automatic water distribution system was coupled with the Positive Mathematical Programming economic model for a sustainable agricultural water operation in the Roodasht irrigation network, Iran. Operational management was carried out based on the economic value of water in each irrigated unit. According to the results, the existing operating system was able to supply 71 and 22% of farmers’ water requirements under normal and water shortage conditions, respectively. However, employing the proposed automated operational-economic approach reduced water consumption by 14.3%, while maintaining the cultivation area by 11% and increasing farmers’ net profit to 840,000 USD under water scarcity. The economic operation can reduce water losses, implement economic strategies in those districts without water marketing mechanisms, and provide sustainable management of limited water resources in hyper-arid regions.
Long-term evaluation of soil salinization risks under different climate change scenarios in a semi-arid region of Tunisia
Authors: Kanzari Sabri , Jaziri Rim , Ali Khouloud Ben , Daghari Issam
Published: February 2021

The project ‘Research and Training on Irrigation with Saline Water in Tunisia’, with the project report published by UNESCO in 1970, was set up to specify Tunisian standards for the use of saline water and to mitigate their effects on crop yields. The objective of this study is to assess the risk of long-term soil salinization by considering the agricultural practices mentioned in the project for the ‘Water Quality’ experiment in the semi-arid region of Cherfech (Tunisia). A Hydrus-1D model was used to simulate the movement of water and the transfer of salts. Soil hydraulic and solute transport parameters were estimated using inverse modeling. Calibration and validation of the model were made for the water and salt profiles carried out with four irrigation qualities QA, QB, QC and QD. Four scenarios over 50 years were studied: (i) S1 with rainfall (400 mm) only; (ii) S2 with rainfall and irrigation (1,400 mm); (iii) S3 with a 2 °C increase in temperature; (iv) S4 with the addition of 100 mm·d−1 of rainfall. The four scenarios highlighted the high risk of soil salinization, especially for the QB, QC and QD qualities after 20 years of irrigation and the deep dynamics of water and salts beyond the root zone which increases the risk of groundwater salinization.
Optimization of Congo red dye adsorption from wastewater by a modified commercial zeolite catalyst using response surface modeling approach
Authors: Khalaf Intisar Hussain , Al-Sudani Farah Talib , AbdulRazak Adnan A. , Aldahri Tahani , Rohani Sohrab
Published: February 2021

In the present work, Zeolite A was modified by using hexadecyltrimethylammonium bromide (HDTMABr) for adsorption of the Congo red (CR) dye from synthetic aqueous solutions. The Modified Zeolite A (MZA) was characterized by XRD, SEM, and FTIR. The influence of solution pH (in the 4–12 range), ionic strength (0.1–1 M), contact time (180 min), initial CR concentration (20–60 mg/L), temperature (24–36 °C), and an adsorbent dose (1–3 g m/L) on the % dye removal and adsorbent capacity were studied. A combined effect of the initial CR concentration and temperature on the CR removal % by MZA was also studied by applying response surface methodology (RSM). Experimental values were in a good agreement with those predicated by a second-order quartic model. A maximum of 99.24% dye removal and adsorbent capacity of 21.11 mg/g was achieved under the following conditions: pH = 7, initial CR concentration = 60 mg/L, temperature = 24 °C, ionic strength = 0.1 M, adsorbent dose = 3 g/L and 90 min contact time. The equilibrium data were subjected to the Langmuir, Freundlich and Temkin isotherms, with the latter providing the best fit while kinetic adsorption studies were conducted by applying three models. The results indicated that the removal process was best described by the pseudo-second-order model. The present study demonstrates that modified MZA can be utilized for the highly efficient CR dye removal.
Correlation between Protein Intake, Fat Free Mass, and Total Lymphocyte Count with Quality of Life in Pulmonary Tuberculosis Patients Undergoing Intensive Phase Treatment in Pekanbaru, Riau Province
Authors: Yunda Dewi Krisna , Witjaksono Fiastuti , Nurwidya Fariz
Published: February 2021

Background: Malnutrition and tuberculosis (TB) have a bidirectional relationship, which interacts between each other. In chronic infection, there is an imbalance between protein degradation and protein synthesis which marked with the loss of fat-free mass (FFM). Malnutrition can cause the atrophy of the thymus gland resulted in the reduction of lymphocyte production. Malnutrition in TB patients will reduce the quality of life. On the other hand, a good quality of life will increase the treatment success rate and decrease the risk of morbidity and mortality. Materials and Methods: A cross-sectional study was conducted in 12 primary health centers (PHC) chosen randomly from 23 PHC in Pekanbaru, Riau Province. The random selection was performed by using simple random sampling (random number generator). Data were collected from May until July 2019. Samples were selected using a consecutive sampling method and 72 subjects fulfilled all research criteria. The interview was used to collect basic characteristic data, dietary intake data, and quality of life score. Anthropometric measurement (body weight, body height, and FFM) and laboratory examination (total lymphocyte count) were done.Results: Research showed median age subjects was 33 years old (18-59 years old). Most of the subjects were male (56.9%), had a middle level of education, low income, were active smokers with underweight nutritional status. More than 50% of subjects had low protein intake, low fat-free mass, normal lymphocyte count and had a good quality of life.Conclusion: There was a statistically significant correlation between fat-free mass with PCS (r=0.239, p=0.044), but not for protein intake and total lymphocyte count.Keywords: fat-free mass, protein, quality of life, total lymphocyte count, tuberculosis
Mesenchymal Stem Cell Derived-Exosomes as Effective Factors in Reducing Cytokine Storm Symptoms of COVID-19
Authors: Kheirkhah Amir Hossein , Shahcheraghi Seyed Hossein , lotfi Malihe , lotfi Marzieh , Raeisi Sanaz , Mirani Zulfiqar
Published: February 2021

Given that conventional therapies are ineffective for COVID-19, obtained exosomes
from stem cells have been proposed as a sustainable and effective treatment. Exosomes are subsets
with lengths between 30 and 100 nanometers, and they can be secreted by different cells. Exosomes
are containing different types of miRNAs, mRNAs, and different proteins. The role of immune
system modulation of exosomes of mesenchymal stem cells has been studied and confirmed
in more than one study. Exosome miRNAs detect and reduce cytokines that cause cytokine storms
such as IL-7, IL-2, IL-6, etc. These miRNAs include miR-21, miR-24, miR-124, miR-145, etc. The
risks associated with treatment with exosomes from different cells are relatively small compared to
other treatments because transplanted cells do not stimulate the host immune system and also has
reduced infection transmission. Due to the ineffectiveness of existing drugs in reducing inflammation
and preventing cytokine storms, the use of immune-boosting systems may be suggested as
another way to control cytokine storm.
Integration of Internet of Things with Quantum Dots: A State-of-the-art of Medicine
Authors: Desai Drashti , Shende Pravin
Published: February 2021

Internet of Things (IoT) emerges as disruptive innovation and development in the fields of drug delivery
and biomedical sciences using on-target active transportation, sensors, wearable devices, real-time diagnostics,
etc. Semiconducting fluorescence emitting material, quantum dots on integration with IoT displayed interesting
results in the healthcare sector, especially in hospitals and pathological laboratories. Presently, the integrated
system is used to improve productivity without the interference of human and offer a cost-effective system.
This integrated system can be used for the detection of various diseases like epilepsy, cancer, diabetes,
etc., and various biomedical applications like energy storage, lights, sensor technology, light filters, etc. The integrated
technology is implemented into the field of medicine for simplifying the approaches in therapeutics
and diagnostic applications. The collected and analyzed data are further useful for healthcare professionals to
find patient-centric solutions. Artificial Intelligence-aided IoT emerges as a novel technology for transmitting
and securing health data. Despite some of the limitations like e-waste and the risk of hacking, an IoT-based QD
system will be considered as a modern healthcare provider with life-saving products for enriching the medical
quality and real-time accessibility.
Statistically Designed Extraction of Herbs Using Ultrasound Waves: A Review
Authors: Arya Ashwani , Chahal Rubal , Nanda Arun , Kaushik Deepak , Bin-Jumah May , Rahman Md. Habibur , Abdel-Daim Mohamed M. , Mittal Vineet
Published: February 2021

Background:

Extraction is the foremost step to isolate the natural constituents from a medicinal
plant and leads the process of development of herbal formulation from bench to bed.

Introduction:

In the field of extraction, the optimization approach helps in achieving better yield and quality
where a response of concern is determined or influenced by various variables. This review aimed at congregating
the application of different statistical designs (CCD/BBD) to optimize the Ultrasound assisted extraction
(UAE) parameters for the recovery of various plant actives belonging to different categories.

Methodology:

The literature published during the last decade in the various reputed databases (Web of Science,
Pubmed, Scopus) was reviewed and compiled to reveal the role of response surface methodology in optimizing
the influential parameters involved in the ultrasound assisted extraction of herbs.

Conclusion:

From the present investigations, it can be concluded that the different variables, such as sonication
power, temperature, time, solute to solvent ratio are generally optimized in UAE of herbs. Moreover, it has also
been evidenced from the review of published data that the flavonoids/phenolic acids (>50%) leads the race for
the extraction of plants using sound waves. It can be said that the statistically designed UAE has a vast prospective
in bringing about a green mutiny in the herbal drug industry and the modeling of various parameters shall
be able to absolutely build up a complete drug innovation course (bench to bed).
The Effect of Pre-operative Autologous Blood Donation on Bone Marrow
Hematopoietic Functions in Rabbits after Hepatectomy
Authors: Zhou Xiao-Fang , Liu Yang , Xu Jia-Ming , Wang Jin-Huo , Li Zhen-Zhou , Zhou Xun , Guo Jian-Rong
Published: February 2021

Background:

Pre-operative autologous blood donation (PABD) is one of the most widely
distributed autologous blood donation means, which has positive effects on erythropoiesis. However,
whether PABD can stimulate the bone marrow hematopoiesis after hepatectomy has not been reported.

Methods:

Totally 80 New Zealand rabbits were randomly divided into 4 groups that included control
group, surgery group, hemodilutional autotransfusion (HA) group and PABD group. Automatic reticulocyte
examination was performed to detect the content of reticulocyte and immature reticulocyte
fractions (IRF). Flow cytometric analysis was employed to monitor the level of CD34+ cells and the
cell cycle status. Southern blotting was conducted to determine the telomere length of CD34+ cells.

Results:

The content of high fluorescence reticulocytes (HFR) and IRF was decreased at 6 h and 24 h
after autotransfusion. However, the level of CD34+ cells was upregulated after PABD. Cell cycle
status analysis revealed that the majority of the CD34+ cells in HA and PABD group were maintained
in G0/G1 phase. The telomere length in HA and PABD group was shortened than that of the control
group and surgery group.

Conclusion:

PABD could promote the bone marrow hematopoietic functions in rabbits after hepatectomy
via stimulating proliferation of CD34+ cells and shortening the telomere length of CD34+ cells,
but the content of HFR was not increased immediately because of the stuck of CD34+ cells in the
G0/G1 phase.
The Roles of β-Carotene in Cardiomyocytes
Authors: Yusuf Inez F. , Lesmana Ronny , Goenawan Hanna , Achadiyani  , Khairani Astrid F. , Fatimah Siti N.
Published: February 2021

Cardiovascular disease (CVD) is considered one of the major causes of mortality
worldwide, with approximately 17.9 million deaths per year. There are several risk factors of
cardiovascular diseases, such as behavioral factors (e.g., tobacco use, imbalanced diet, alcohol
misuse, and lack of physical activities) and other underlying health-related factors (e.g., hypertension,
dyslipidemia, and hyperglycemia). These factors are also correlated with the pathophysiology
of CVD, and one of the determinants of early aging is the poor overall quality of life. One
of the main strategies to prevent these risks is by achieving a healthy lifestyle, including the consumption
of natural supplements. Recently, β -carotene has gained the attention of researchers
owing to its natural antioxidant properties. It is found in fruit and vegetable compounds. In this
article, we review the effects of β-carotene as an antioxidant that counteracts free radicals and cytoprotective
agents that have positive benefits, such as preventing several age-related diseases
improvement of the health of the cardiac muscle.
Reducing Contact Resistance of Carbon Nanotubes by Doping of Nickel
Nanoparticles
Authors: Liang Zhiqi , Dong Shuai , Chang Chunrui , Zhang Zhiming , An Libao
Published: February 2021

Background:

In micro- and nano-electronic devices, there is often a high contact resistance
between carbon nanotubes (CNTs) and metals, which leads to the heating of electronic devices
and the loss of a large amount of energy. Doping will be used to improve the electrical contact
performance between CNTs and metals.

Significance:

A simple and low-cost electroless deposition technique is used to prepare nickel-doped
carbon nanotubes (CNT-Ni) under different doping conditions and explore the influence of different
nickel (Ni) doped samples on the electrical contact properties of CNTs.

Method:

In this study, the transition metal Ni was chosen to prepare CNT-Ni by electroless deposition
method using nickel chloride hexahydrate (NiCl2•6H2O) as a medium. The morphology and
structure of treated CNTs were characterized through scanning electron microscopy (SEM), transmission
electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Raman spectrometer,
and ultraviolet photoelectron spectrometer (UPS). The contact resistance between CNTs and metals
was measured by inductance capacitance resistance (LCR) tester.

Result:

The morphological characterization results showed that the incorporated Ni nanoparticles
had moderate particle size and good combination with CNTs. The structural characterization indicated
that the core component of the doped nanoparticles was transition metal element Ni, and the doping
type was P-type, with the significantly increased work function of the doped CNTs. And the average
value of the contact resistance between the Ni-doped CNTs and the gold electrode decreased
by nearly 71.63%.

Conclusion:

This doping method can be used to effectively reduce the contact resistance between
CNTs and metals. The research on the preparation of CNT-Ni is of practical significance in reducing
the heating of electronic devices in practical use and then improving the performance and service life
of devices.
Virtual Screening of the Flavonoids Compounds with the SARS-CoV-2 3C-like Protease as the Lead Compounds for the COVID-19
Authors: Adisurja Gabriella Patricia , Parikesit Arli Aditya
Published: February 2021

As of 1st of September 2020, the COVID-19 pandemic has reached an unprecedented level
of more than 25 million cases with more than 850,000 deaths. Moreover, all the drug candidates
are still undergoing testing in clinical trials. In this regard, a breakthrough in drug design is necessary.
One strategy to devise lead compounds is leveraging natural products as a lead source. Several
companies and research institutes are currently developing anti-SARS-CoV-2 lead from natural
products. Flavonoids are well known as a class of antiviral compounds library. The objective of
this research is to employ virtual screening methods for obtaining the best lead compounds from
the library of flavonoid compounds. This research employed virtual screening methods that comprised
of downloading the protein and lead compound structures, QSAR analysis prediction, iterations
of molecular docking simulation, and ADME-TOX simulation for toxicity prediction. The
QSAR analysis found that the tested compounds have broad-spectrum antiviral activity, and some
of them exhibit specific binding to the 3C-like Protease of the Coronavirus. Moreover, juglanin
was found as the compound with the fittest binding with the Protease enzyme of SARS-CoV-2. Although
most of the tested compounds are deemed toxic by the ADME-Tox test, further research
should be conducted to comprehend the most feasible strategy to deliver the drug to the infected
lung cells. The juglanin compound is selected as the fittest candidate as the SARS-CoV-2 lead compound
in the tested flavonoid samples. However, further research should be conducted to observe
the lead delivery method to the cell.
Angiotensin Converting Enzyme-2: A Doorway for SARS-CoV-2
Authors: Pandey Vikas , Kanwar Indu Lata , Haider Tanweer , Gour Vishal , Vishwakarma Monika , Bakshi Avijit Kumar , Yadav Ravishankar , Soni Vandana
Published: February 2021

:

The novel coronavirus severe acute respiratory syndrome Corona Virus-2 (SARS-CoV-
-2) has become a pandemic, as declared by WHO in March 2020 producing deleterious effects on
patients worldwide. The angiotensin-converting enzyme-2 (ACE-2) has been recognized as the coreceptor
for SARS-CoV-2 infections and may act as a therapeutic step in blocking the enzyme to reduce
SARS-CoV-2 expression and further cellular entry. Presently, the role of ACE-2 in coronavirus
disease 2019 (COVID-19) infection has been known and the experts have started working
on the enzyme ACE-2 for the management and treatment of this pandemic disease. The binding of
spike (S) protein of SARS-CoV-2 to these receptors is the most important step and plays a key role
in viral replication, thus this enzyme is becoming the doorway for the entry and spread in the human
body causing asymptomatic pneumonia and severe of which is leading to death. As no specific
method to prevent and treat this disease is available, the use of ACE-2 as a targeting ligand with
COVID-19 virus spike protein could be helpful in the proper management of SARS-CoV-2 pneumonia.
Fernando Namora e a Pintura
Authors: Ferreira Cláudia
Published: February 2021

This text discusses paintings by Fernando Namora, a craft he never abandoned although he kept it private. This aspect of his creative works has been virtually forgotten, to the extent that it is a surprise to discover the extent of his dedication and authenticity. First, we clarify our conceptual frame and then we present the set of paintings which are part of the collection of Casa Museu Fernando Namora; Finally, through dance, we experiment a dialogue between two of his works: Estudo/ Study (1944/45) and Auto-retrato/ Self-portrait (1947).
The Effect of Atherosclerotic Cardiovascular Disease Risk Score Knowledge on Risk Reduction in Patients Admitted to the Obesity Center
Authors: YILDIRIM Duygu İlke , ERYILMAZ Mehmet
Published: February 2021

Objectives: Atherosclerotic cardiovascular disease (ASCVD) is the most common cause of mortality and morbidity worldwide. The aim of this study was to evaluate the effect of atherosclerotic cardiovascular disease risk score knowledge in obese patients aged 40-79 years on risk reduction in 3 months. Methods: This descriptive and cross-sectional study was approved by the clinical ethics committee. The study was conducted with 300 consecutive volunteer patients who applied to Konya Obesity Center. All patients older than 40 years of age and volunteered to participate in the study were included in the study. Patients with coronary artery disease, heart failure, major depression, treated for arrhythmias, younger than 40 years of age, and those who could not come to the follow-up 3rd-month controls were excluded. The patients admitted to the obesity center were evaluated according to the results of routine examinations. Results: Knowledge of ASCVD risk score, age, gender, occupation, marital status, diabetes, hyperlipidemia, SBP, WC, HC, TC, LDL, triglycerides, glucose, HbA1c and AST were all significantly determinants of ASCVD risk in our univariate analysis. Knowledge of ASCVD (odds ratio [OR]: 1725.917; 95% confidence interval [CI]:208.675-14275.098; p<0.001), age (OR: 0.936; 95% CI:0.882-0.994; p=0.030), gender (OR: 65.848; 95% CI: 11.455-378.505; p<0.001), occupation (OR: 0.410; 95% CI: 0.259-0.648; p<0.001) and total cholesterol (OR: 0.960; 95% Cl: 0.940-0.980; p<0.001) were defined as multivariate predictors for ASCVD risk reduction. Conclusion: In conclusion, our analysis showed that knowledge of ASCVD risk score, age, gender, occupation, and TC at admission were the most potent predictors of decrease in ASCVD risk scoring. In order to achieve risk reduction regarding CVDs, patients’ awareness about knowing their CVD risk plays a crucial role.
A New Comorbidity Accompanying Obesity: Renal Angiomyolipoma
Authors: BULCA ACAR Aysima , NUR EKE Remziye
Published: February 2021

Objective: Obesity is an important health concern all around the world and considered in relation to a number of comorbidities. In this study, we aimed to evaluate the incidence of renal angiomyolipoma (AML) in obese patients. Method: This retrospective study included 288 obese patients, who were followed up at the Obesity Center of the University of Health Sciences, Antalya Training and Research Hospital between 01/11/2018 and 01/02/2020. The laboratory parameters and the reports of the abdominal ultrasound scans (USG) taken when the patients first presented to our unit were all reviewed. The patients were divided into two groups: those with and without renal AML based on the abdominal USG reports, and were compared in terms of serum hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), erythrocyte count (RBC), blood urea nitrogen (BUN), creatinine and uric acid levels. Results: Of the patients, 93.05% were female and 6.94% were male. The mean age was 51.91±9.31 (21-73) years, the average body mass index (BMI) was 36.4 (30-65.19) kg/m2. Ten patients (3.47%) had renal AML found on the abdominal USG imaging reports. While the incidence of renal AML in the general population is reported to be 0.13%-0.44%, it was found 3.47% in our study with obese patients. Conclusion:The incidence of renal AML is increasing in obese patients. Associated with many comorbidities, obesity may also constitute a risk factor for renal AML. In order to determine the relationship between obesity and AML, more studies are needed with multi-centered and broader scopes.
Модифицированные параметры приема 1-3-композитов на основе сегнетоэлектрических кристаллов
Authors: Тополов В.Ю. , Исаева А.Н.
Published: February 2021

A system of modified figures of merit is studied for fibrous piezo-active composites ‘system of aligned ferroelectric crystal rods – polymer matrix’ with 1–3 connectivity in a wide volume-fraction range of the crystal component. The modified figures of merit are important to estimate an effectiveness of harvesting, accumulating and transducing energy in a piezo-element at a constant mechanical stress or constant strain. Polydomain [001]-poled (1 – x)Pb(Mg1/3Nb2/3)O3 – xPbTiO3 (0.28  x  0.33) and [Liv(K1-yNay)1-v](Nb1-zTaz)O3:Mn (v = 0.06, y = 0.1 … 0.3, z = 0.07 … 0.17) crystals serve as piezoelectric components. Comparison of parameters evaluated for the 1–3 composites by means of the matrix method and effective field method is made. Analysed is the role of electromechanical properties of the crystal component in forming the modified figures of merit of the composite. Based on results on modeling the effective properties and related modified figures of merit, advantages of the lead-free 1–3 composite over its analogs based on (1 – x)Pb(Mg1/3Nb2/3)O3 – xPbTiO3 crystals are shown.
Tłumaczenie – z poprawkami Jana Maleckiego – Ewangelii według św. Mateusza przez Stanisława Murzynowskiego
Authors: Lichański Jakub Z.
Published: February 2021

Celem przedstawionych badań były opis i analiza poprawek rękopiśmiennych w królewieckiej edycji Ewangelii Świętej Pana Jezusa Chrystusa wedle Mateusza świętego (1551). Tłumaczenia dokonał Stanisław Murzynowski, a poprawki naniósł Jan Sandecki-Malecki. Mimo sporej literatury przedmiotu autor powraca do tego sporu, aby pokazać kształtowanie się języka polskiej biblistyki w połowie wieku XVI. Jest to tym bardziej interesujące, iż zgodnie ze świadectwem Łukasza Górnickiego właśnie tłumaczenie Biblii miało wielkie znaczenie dla rozwoju języka polskiego. Zaprezentowane wyniki są wstępem do szerszych badań tytułowego zagadnienia.
Rola komentatora liturgicznego w ramach posługi słowa i jego formacja biblijna
Authors: Stypułkowska Beata
Published: February 2021

W niniejszym artykule została przeprowadzona refleksja nad rolą komentatora liturgicznego w ramach posługi słowa, na którą składały się kwestie związane z udziałem osób świeckich w posłudze słowa i pomocniczą rolą świeckich w liturgii słowa (1), homilią i komentarzem liturgicznym przed czytaniami (2) oraz formacją biblijną komentatorów (3). Została ukazana pomocnicza rola komentatora liturgicznego przygotowującego komentarz przed czytaniami wobec kaznodziei głoszącego podczas liturgii homilię, która jest przepowiadaniem misterium Chrystusa. Zwrócono uwagę na kerygmat, który powinien być zasygnalizowany przez komentarz i obwieszczony przez homilię. W formacji biblijnej komentatorów zaproponowano lectio divina jako metodę przygotowującą do interpretacji słowa Bożego w liturgii.
Została ukazana pomocnicza rola komentatora liturgicznego przygotowującego komentarz przed czytaniami wobec homilisty, głoszącego podczas liturgii homilię, która jest przepowiadaniem misterium Chrystusa. Zwrócono uwagę na kerygmat, który powinien być zasygnalizowany przez komentarz i obwieszczony przez homilię. W formacji biblijnej komentatorów zaproponowano lectio divina jako metodę przygotowującą do interpretacji słowa Bożego w liturgii.
Słowa kluczowe: komentator liturgiczny, posługa słowa, formacja biblijna
Public Knowledge, Attitudes, and Practices Related to COVID-19 in Iran: Questionnaire Study
Authors: Abbasi-Kangevari Mohsen , Kolahi Ali-Asghar , Ghamari Seyyed-Hadi , Hassanian-Moghaddam Hossein
Published: February 2021

Background

The COVID-19 pandemic is a rapidly growing outbreak, the future course of which is strongly determined by people’s adherence to social distancing measures.

Objective

The objective of this study was to determine the knowledge level, attitudes, and practices of the Iranian population in the context of COVID-19.

Methods

A nationwide study was conducted from March 24 to April 3, 2020, whereby data were collected via an online self-administered questionnaire.

Results

Responses from 12,332 participants were analyzed. Participants’ mean knowledge score was 23.2 (SD 4.3) out of 30. Most participants recognized the cause of COVID-19, its routes of transmission, its symptoms and signs, predisposing factors, and prevention measures. Social media was the leading source of information. Participants recognized the dangers of the situation and felt responsible for following social distancing protocols, as well as isolating themselves upon symptom presentation. Participants’ mean practice score was 20.7 (SD 2.2) out of 24. Nearly none of the respondents went on a trip, and 92% (n=11,342) washed their hands before touching their faces.

Conclusions

Knowledge of COVID-19 among people in Iran was nearly sufficient, their attitudes were mainly positive, and their practices were satisfactory. There is still room for improvement in correcting misinformation and protecting people from deception. Iranians appear to support government actions like social distancing and care for their and others’ safety.
A Digital Health Intervention (SweetGoals) for Young Adults With Type 1 Diabetes: Protocol for a Factorial Randomized Trial
Authors: Stanger Catherine , Kowatsch Tobias , Xie Haiyi , Nahum-Shani Inbal , Lim-Liberty Frances , Anderson Molly , Santhanam Prabhakaran , Kaden Sarah , Rosenberg Briana
Published: February 2021

Background

Many young adults with type 1 diabetes (T1D) struggle with the complex daily demands of adherence to their medical regimen and fail to achieve target range glycemic control. Few interventions, however, have been developed specifically for this age group.

Objective

In this randomized trial, we will provide a mobile app (SweetGoals) to all participants as a “core” intervention. The app prompts participants to upload data from their diabetes devices weekly to a device-agnostic uploader (Glooko), automatically retrieves uploaded data, assesses daily and weekly self-management goals, and generates feedback messages about goal attainment. Further, the trial will test two unique intervention components: (1) incentives to promote consistent daily adherence to goals, and (2) web health coaching to teach effective problem solving focused on personalized barriers to self-management. We will use a novel digital direct-to-patient recruitment method and intervention delivery model that transcends the clinic.

Methods

A 2x2 factorial randomized trial will be conducted with 300 young adults ages 19-25 with type 1 diabetes and (Hb)A1c ≥ 8.0%. All participants will receive the SweetGoals app that tracks and provides feedback about two adherence targets: (a) daily glucose monitoring; and (b) mealtime behaviors. Participants will be randomized to the factorial combination of incentives and health coaching. The intervention will last 6 months. The primary outcome will be reduction in A1c. Secondary outcomes include self-regulation mechanisms in longitudinal mediation models and engagement metrics as a predictor of outcomes. Participants will complete 6- and 12-month follow-up assessments. We hypothesize greater sustained A1c improvements in participants who receive coaching and who receive incentives compared to those who do not receive those components.

Results

Data collection is expected to be complete by February 2025. Analyses of primary and secondary outcomes are expected by December 2025.

Conclusions

Successful completion of these aims will support dissemination and effectiveness studies of this intervention that seeks to improve glycemic control in this high-risk and understudied population of young adults with T1D.

Trial Registration

ClinicalTrials.gov NCT04646473; https://clinicaltrials.gov/ct2/show/NCT04646473

International Registered Report Identifier (IRRID)

PRR1-10.2196/27109
Characteristics and Outcomes of Physician-to-Physician Telephone Consultation Programs: Environmental Scan (Preprint)
Authors: Tian Peter George Jaminal , Harris Jeffrey Richard , Seikaly Hadi , Chambers Thane , Alvarado Sara , Eurich Dean
Published: February 2021

BACKGROUND

Telephone consultations between physicians provide quick access to medical advice, allowing patients to be cared for by calling physicians in their local settings.

OBJECTIVE

As part of a quality assurance study of a physician-to-physician consultation program in Alberta, Canada, this environmental scan aims to identify the characteristics and outcomes of physician-to-physician telephone consultation programs across several countries.

METHODS

We searched 7 databases to identify English publications in 2007-2017 describing physician-to-physician consultations using telephones as the main technology. To identify Canadian programs, the literature search was supplemented with an additional internet search.

RESULTS

The literature search yielded 2336 citations, of which 17 publications were included. Across 7 countries, 14 telephone consultation programs provided primary care providers with access to various specialists through hotlines, paging systems, or call centers. The programs reported on the avoidance of hospitalizations, emergency department visits and specialty visits, caller satisfaction with the telephone consultation, and cost avoidance.

CONCLUSIONS

Telephone consultation programs between health care providers have facilitated access to specialist care and prevented acute care use.
Evaluasi Kesesuaian Penggunaan Antbiotik pada Pasien dengan Infeksi Methicillin Resistant Staphylococcus Aureus (MRSA) di RSUD. Dr. Moewardi Surakarta
Authors: Azzahra Tristina Devi , Nuryastuti Titik , Puspitasari Ika
Published: February 2021

MRSA is one of the Multi Drug Resistant Organism (MDRO) with a high number of cases and problem. Incidence of MRSA in Indonesia is quite significant every years. In 1986 there were 2.5%, 1993 increased to 9.4% and in 2006 23.5%. The problem is methicillin is no longer effective and other antibiotics vary in efficacy. The aims of this reasearch was to evaluate the used of antibiotics in patients with MRSA infection in Dr. Moewardi Hospital in Surakarta. The study was performed using retrospective Cohort study to examine the relationship between suitability antibiotic to clinical outcomes in patients with MRSA infection in Dr. Moewardi Hospital in Surakarta during period 1 January 2017 - 31 December 2018. The evaluation was conducted to the suitability of type, dose, frequency, duration of antibiotic use and pharmacokinetic profile. Chi-square test was used to analyse the relationship of antibiotic suitability to clinical outcomes including predicted pharmacokinetic parameters for clinical outcomes.There were 28 samples with MRSA infection tested in this study. Twenty one patients (75%) used appropriate antibiotics showed good clinical outcome 21 patients (85,7%) and 7 patients (25%) with unsuitable antibiotics showed good clinical outcome 71,4%.Keywords: antibiotic, clinical outcome, pharmacokinetic, MRSA.
Analisis Kepuasan Pasien Terhadap Pelayanan Kefarmasian Menggunakan Metode Servqual Berdasarkan Status Akreditasi di Kabupaten Ogan Komering Ilir
Authors: Amrullah Hafizh , Satibi Satibi , Fudholi Achmad
Published: February 2021

Puskesmas sebagai fasiltas kesehatan tingkat pertama dituntut untuk selalu meningkatkan mutu pelayanan dan keselamatan pasien. Akreditasi menjadi sebuah metode dalam meningkatkan pemerataan dan kualitas pelayanan kesehatan di puskesmas. Diperlukan adanya evaluasi penerapan standar akreditasi pelayanan kesehatan di puskesmas untuk menilai efektivitas akreditasi puskesmas, salah satunya dengan survei kepuasan pasien. Penelitian ini bertujuan untuk menganalisis perbedaan harapan dan kenyataan terhadap mutu pelayanan kefarmasian di puskesmas terakreditasi dan mengetahui perbedaan skor gap kepuasan pasien terhadap mutu pelayanan kefarmasian. Penelitian deskriptif analitik ini dilakukan dengan pendekatan cross-sectional. Subyek penelitian adalah pasien di puskesmas yang pelayanan kefarmasiannya diselenggarakan oleh tenaga kefarmasian menggunakan metode non-probability sampling berdasarkan teknik purposive sampling. Instrumen yang digunakan adalah kuesioner yang disusun berdasarkan teknik ServQual model. Dimensi responsiveness menduduki peringkat teratas gap kepuasan puskesmas terakreditasi. Dari kelima dimensi, kesemuanya berbeda signifikan antara skor harapan dan kenyataan dengan probabilitas 0,000 (p<0,05) kecuali aspek emphaty. Uji beda gap kepuasan pasien puskesmas terakreditasi dan puskesmas tidak terakreditasi menghasilkan perbedaan yang nyata antara keduanya, probabilitas = 0,000 (p<0,05). Terdapat perbedaan yang nyata antara rendahnya kinerja pelayanan kefarmasian dengan tingginya harapan pasien puskesmas terakreditasi, namun  di sisi lain bahwa status akreditasi berpengaruh terhadap kepuasan pasien puskesmas terakreditasi.
Aktivitas Antibakteri dan Uji Sifat Fisik Sediaan Gel Dekokta Sirih Hijau (Piper betle L.) Sebagai Alternatif Pengobatan Mastitis Sapi
Authors: Irianto Iramie Duma Kencana , Purwanto Purwanto , Mardan Marwan Triafrian
Published: February 2021

Mastitis adalah radang yang terjadi pada ambing susu sapi dan dapat menyebabkan penurunan produktivitas sapi perah secara drastis. Senyawa fenolik alam seperti flavonoid dan tanin diketahui dapat membunuh bakteri S. aureus dan E. coli. Dekokta daun sirih hijau (DDSH) yang mengandung senyawa fenolik pada konsentrasi 20% diketahui mampu membunuh bakteri S.aureus dan E.coli. Sediaan gel adalah sediaan yang bersifat menyejukkan, melembabkan, mudah penggunaannya. Penelitian ini bertujuan untuk mencari formula terbaik dengan memperhatikan daya antibakteri dan sifat fisik gel dalam setiap formula. Hasil penelitian ini menunjukkan bahwa peningkatan konsentrasi DDSH menghasilkan gel dengan pH dan viskositas yang semakin rendah, namun daya antibakteri yang semakin besar, sedangkan peningkatan konsentrasi karbopol menyebabkan peningkatan viskositas gel. Berdasarkan daya antibakteri dan sifat fisik gel dalam setiap formula, maka formula 4 (terdiri dari 62,5% DDSH dan 0,875% karbopol) merupakan formula yang optimal dalam penelitian ini.
Crucial Workplace Conversations: Productive Debate and Disagreement
Authors: MD, MBA, FACR Peter Kalina,
Published: February 2021

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Efficacy classification of modern therapies in multiple sclerosis
Authors: Samjoo Imtiaz A , Worthington Evelyn , Drudge Christopher , Zhao Melody , Cameron Chris , Häring Dieter A , Stoneman Dee , Klotz Luisa , Adlard Nicholas
Published: February 2021

Background:
The Association of British Neurologists (ABN) 2015 guidelines suggested classifying multiple sclerosis therapies according to their average relapse reduction. We sought to classify newer therapies (cladribine, ocrelizumab, ofatumumab, ozanimod) based on these guidelines.
Materials & methods:
Therapies were classified by using direct comparative trial results as per ABN guidelines and generating classification probabilities for each therapy based on comparisons versus placebo in a network meta-analysis for annualized relapse rate.
Results:
For both approaches, cladribine and ofatumumab were classified as high efficacy. Ocrelizumab and ozanimod (1.0 mg) were classified as moderate or high efficacy depending on the approach used.
Conclusion:
Cladribine and ofatumumab have an efficacy comparable with therapies classified in the ABN guidelines as high efficacy.
Evaluación de quitosano comercial y extractos acuosos de mesocarpio de coco (Cocos nucifera L.) para el control de Rhizopus stolonifer aislado de guanábana (Annona muricata L.): Pruebas in vitro
Authors: Cortés-Rivera Héctor Javier , González-Estrada Ramsés Ramón , Huerta-Ocampo José Ángel , Blancas-Benítez Francisco Javier , Gutiérrez-Martínez Porfirio
Published: February 2021

La eficacia antifúngica de los extractos acuosos de mesocarpio de coco (Cocos nucifera L.) (EAC) y el quitosano comercial (QC) aplicados de manera individual y en combinación se evaluó contra Rhizopus stolonifer en términos de crecimiento micelial, esporulación y germinación de las esporas, así como la obtención de los modelos de crecimiento primario en dos temperaturas de almacenamiento (15-25 ºC). La aplicación de los EAC al 10% redujo significativamente el crecimiento micelial de R. stolonifer (58.81 ± 6.48%); por otro lado, el QC (1.5%) mostró un efecto de control de hasta un 87%, sin embargo, la combinación de los EAC (10%) con el QC (1.5%) fue más efectiva al reducir el crecimiento micelial (> 93 %). Todos los tratamientos fueron efectivos para disminuir la producción de esporas (> 94 %) en comparación con el control (agar). El QC al combinarse con los EAC fue más efectivo inhibiendola elongación del tubo germinal (> 98 %) comparado con los tratamientos individuales (< 48 %). El modelo modificado de Gompertz mostró un ajuste adecuado para ambos rangos de temperatura (> 98-99 %) observándose diferencias significativas (p ≤ 0.05) entre las variables de velocidad máxima (Vmáx) y periodo de latencia (ƛ), no obstante, todos los tratamientos mostraron un efecto fungistático sobre el desarrollo micelial de R. stolonifer. La combinación de los EAC y el QC puede ser una alternativa eco-amigable contra la pudrición suave de los frutos de guanábana.
Analisis pengaruh tingkat pendidikan dan pertumbuhan ekonomi terhadap tingkat kemiskinan di Provinsi Jambi
Authors: Nurhasanah Nurhasanah , Safri Muhammad , Edi Jaya Kusuma
Published: February 2021

The purpose of this research: (1) To know the development of education level and economic growth to the level of poverty in Jambi Province; (2) To know the influence of education level and economic growth to Poverty Level in Jambi Province. The method of analysis used in this study deskrptif analysis and quantitative analysis with the analysis tool is multiple linear regression. Data processing is done by using Microsoft Excel Software program and Eviews 8.0. The results of this study are the first overall development level of education (TP) during the period 2000-2016 on average increased by 0.64 percent. Economic growth in 2016 of 7.5 percent increase compared to the year 2015 of 5.9 percent. The four variables together significantly affect the poverty rate with the coefficient of TP of -0.080240, PE coefficient of -0.256608 percent. For the value of coefficient of determination (R2) of 0.614738 shows that TP and PE together affect the poverty rate of 61.47 while the rest of 38.53 percent explained by other variables not included in the model estimation.

Keywords: Poverty Level, Education Level, and Economic Growth.