bluuebunny/crossref_metadata_2025 huggingface dataset:
A fenntarthatóságot szolgáló üzleti gyakorlatok fogyasztói elfogadása a COVID idején – Egy egyetemista minta tapasztalatai
Authors: Csutora Mária , Szigeti Cecília , Harangozó Gábor
Published: February 2024

A COVID-19 járványhoz kapcsolódó korlátozások jelentős hatást gyakoroltak a fenntarthatóságra fókuszáló üzleti gyakorlatok elterjedésére. A tanulmány célja kettős: egyrészt feltárni, hogyan változott a fenntartható üzleti gyakorlatok fogyasztói elfogadása a járvány hatására, másrészt megvizsgálni, várható-e visszarendeződés a járvány elültével, azaz tetten érhető-e részleges vagy teljes visszapattanó hatás. A szerzők egy 622 fős minta alapján leíró statisztikák, illetve faktor- és klaszterelemzés segítségével vizsgálták a fentieket. Az eredmények alapján a fogyasztók nyitottsága általánosságban nőtt a vizsgált gyakorlatokkal kapcsolatban, egyedül a megosztáson alapuló megoldások (szállás, közlekedés) esetében csökkent. A fenntarthatóságot célzó üzleti gyakorlatok elfogadásában a COVID-hoz kapcsolódó korlátozások elmúltával ugyanakkor visszarendeződés várható (ez részben már megfigyelhető is, például az anyagi fogyasztás és az elmaradt utazások tekintetében). A várt visszapattanó hatás jelentős a fenntarthatósági gyakorlatok iránt nyitott klaszterek („Felelős zöldek” és „Innovatívak”) körében is, ami különösen fontossá teszi, hogy vállalati innovációk, illetve szakpolitikai és oktatási megoldások révén megtartható legyen a válság idején elért nagyobb nyitottság.
Endoscopic Ultrasound-Guided Glue Embolization for Left Gastric Artery Pseudoaneurysm Presenting as Hemosuccus Pancreaticus After Failed Radiological Intervention
Authors: Rai Praveer , Kumar Pankaj , Verma Prabhat Kumar , Agarwal Kartik , Singh Anil Kumar
Published: February 2024

Hemosuccus pancreaticus is characterized by intermittent bleeding from the ampulla of Vater due to the rupture of a pseudoaneurysm. There are significant diagnostic and therapeutic challenges associated with this rare and potentially life-threatening condition. We present a rare case in an 18-year-old man who presented with recurrent episodes of hematemesis and melena due to hemosuccus pancreaticus as a result of a left gastric artery pseudoaneurysm. Initial radiological angioembolization failed because of median arcuate ligament syndrome, and endoscopic ultrasound-guided glue embolization was successfully performed. This case further reinforces the importance of endoscopic ultrasound-guided therapy in the management of pseudoaneurysm after failed radiological treatment.
Enhancing Islamic Educational Quality through Output-Based Quality Assurance: A Literature Review Perspective
Authors: Sulfiani Sulfiani , Nora Saiva Jannana  , Sedya Sentosa
Published: February 2024

This research undertakes a comprehensive literature review to analyze output-based quality assurance in Islamic educational institutions. The study systematically reviews scholarly articles published between 2019 and 2023, focusing on quality assurance and educational institution outputs. The findings highlight the pivotal roles of vision and mission alignment, strategic program implementation, robust facilities, and the cultivation of academically and competitively adept graduates. Key outcomes from the review include the importance of effective communication in achieving Islamic institutional goals, the significance of academic and non-academic flagship programs, and the criticality of a strong teaching and learning process. The study also reveals the efficacy of integrating strategic planning, stakeholder engagement, and a balance of academic excellence and character development in enhancing educational quality. Despite its comprehensive nature, the research acknowledges limitations in its scope, primarily its reliance on existing literature, which may not encompass all possible educational contexts. Future research should explore diverse educational settings further and assess the long-term impacts of quality assurance strategies on student outcomes and Islamic institutional reputation. This study significantly contributes to the discourse on educational quality assurance, advocating for comprehensive, adaptable, and inclusive strategies in response to the evolving demands of the educational landscape.
Lexical knowledge, memory and experience
Authors: Dąbrowska Ewa , Gedik Tan Arda
Published: February 2024

Knowing a language involves knowing a large number of idiosyncratic units such as individual words and collocations which must be learned from the input. This study explores the role of implicit and explicit memory, as well as language experience, and specifically print exposure, with regard to adult native English speakers’ knowledge of vocabulary and collocations. Consistent with prior research, our findings reveal a strong correlation between print exposure and performance on both language tasks. However, contrary to predictions, there were no significant effects of either implicit or explicit memory on either task. We argue that this is most likely due to the fact that language learning relies primarily on memory for associations between form and meaning and between words rather than memory sequences of meaningless phonological forms.
A reference constructicon as a database
Authors: Patel Malin , Garibyan Armine , Winckel Elodie , Evert Stephanie
Published: February 2024

This article explores the importance of database architecture in building a reference constructicon. Several reference constructicons have been implemented for various languages (FrameNet Constructicon, English Constructicon, Japanese FrameNet Constructicon, German Constructicon, Swedish Constructicon, FrameNet Brasil Constructicon, Russian Constructicon). However, most constructicon projects do not provide explicit information about their implementation or the underlying data model. A recent reference constructicon project dealing mainly with the English language is CASA (Construction Grammar Approach to Syntactic Analysis). In this paper, we present the data model underlying CASA in detail and its current implementation as a relational database and web interface. Relational databases are widely used for many different applications and allow large amounts of data to be stored and managed in a structured and efficient way.
Modifications in impeller blades for high efficiency mixing of pseudoplastic fluid in a stirred tank
Authors: Gu Deyin , Yan Linjie , Xu Hui
Published: February 2024

Self-similarity impeller (SS impeller) was applied to enlarge the cavern region for the mixing of pseudoplastic fluid. The mixing characteristics of pseudoplastic fluid in an SS impeller stirred tank were explored by employing experimental and numerical simulation. The results indicated that the utilization of SS impeller resulted in significant improvement in the largest Lyapunov exponent of mixing system, as well as reduced mixing time and decreased mixing efficiency number compared with pitched-blade impeller (PB impeller) operating at an equivalent power consumption per unit volume. A reduction in power consumption was obtained through the application of self-similar configuration for the impeller blades. Meanwhile, SS impeller could enhance the fluidity of pseudoplastic fluid, minimize the stagnation regions, and enlarge the cavern region. This phenomenon was even more pronounced as the increase in self-similar iteration number of SS impeller. It was found that the design of self-similar structure for impeller blades could expand the cavern region and enhance the mixing efficiency for the mixing of pseudoplastic fluid, particularly as the self-similar iteration number increased.
Geomagnetic storm effect on equatorial ionosphere over Sri Lanka through total electron content observations from continuously operating reference stations network during Mar–Apr 2022
Authors: Thiruvarangan Venuraj , Rajavarathan Jenan , Panda Sampad Kumar , Swarnalatha Jayakody Jayakody Arachichilage
Published: February 2024

The technological advancements in the current era have highlighted the increasing significance of satellite-based positioning, navigation, and timing services in a wide range of dynamic and critical applications. This has led to significant efforts towards enhancing the performance of global navigation satellite systems (GNSS) operating under challenging ionospheric conditions. The Sri Lankan ionosphere region is a focal point of equatorial aeronomy scientists, being situated in the southernmost landmass of the Indian longitude sector within the vicinity of the magnetic equator where a combination of electric, wind, and temperature dynamics exerts a substantial influence on the ionosphere but was relatively unexplored in the past. In the present work, we employed a Kriging interpolation technique on the total electron content (TEC) variables from ten GNSS receivers operating under the Continuously Operating Reference Stations (CORS) network in Sri Lanka first ever of its kind to deliver two-dimensional regional ionospheric TEC maps at hourly intervals, both during quiet and disturbed ionospheric conditions in the equinoctial March and April months of 2022. The latitudinal variation patterns are discernable from the hourly TEC maps. Furthermore, a comparative analysis of the performance of GNSS-derived TEC with that of the routinely published Global Ionospheric Maps (GIMs) confirms overestimation characteristics of the latter irrespective of the local time of observation. The generated regional ionospheric maps are fairly responsive to the onset of the storm and the recovery phase thereafter. The extent of nighttime ionospheric irregularity is also probed through the rate of TEC index (ROTI) variations, demonstrating that the irregularities were insignificant during the selected storm event.
The effects of watching subtitled videos on the perception of L2 connected speech by L1 Chinese-L2 English speakers
Authors: Zhu Yanjiao , Hu Jiehui
Published: February 2024

The current study explores whether watching subtitled videos could facilitate L1 Chinese-L2 English speakers’ perception of L2 English connected speech. Three hundred ninty seven Chinese college students of L2 English completed a video-based spot dictation task after watching English videos with or without L1/L2 subtitles, featuring various connected speech types (e.g., linking, deletion, and their combinations). Results suggested an overall facilitation effect of watching videos on L2 connected speech perception, which was modulated by proficiency, subtitle form, and the complexity of connected speech. First, subtitled videos were more facilitative than non-subtitled videos in L2 perception. Second, participants with higher L2 proficiency better perceived English connected speech than those with lower proficiency. Third, the more connective devices an item used, the more difficult it was for L2 perception. When this complexity was controlled, the L2 perception was not influenced by connected speech type. Finally, the complexity of connected speech also mediated the subtitle facilitation effects. When the connected speech involved triple connective devices, L2 speakers benefited more from L1 subtitles than L2 subtitles. The findings can provide insights into multi-modal speech perception and English connected speech learning.
Recent advance in electrochemical immunosensors for lung cancer biomarkers sensing
Authors: Fu Li , Liu Xiaozhu , Cao Junyi , Li Huan , Xie Anyou , Liu Yue
Published: February 2024

Lung cancer has a high mortality rate largely due to late-stage diagnosis. Detecting protein and genetic biomarkers through electrochemical immunosensors enables non-invasive early diagnosis. This review discusses recent advances in electrochemical immunosensors for detecting clinically relevant lung cancer biomarkers. The use of nanomaterials like graphene, carbon nanotubes, metal nanoparticles, and conducting polymers in sensor fabrication improves electron transfer kinetics, enhances signal transduction, and allows higher antibody loading. Smart surface immobilization strategies optimize antibody orientation and binding capacity. Amplification approaches utilizing nanomaterials, enzymes, polymers, dendrimers, and DNA nanostructures are applied to enhance output signal per binding event. Various electroanalytical techniques including amperometry, potentiometry, impedance spectroscopy, and voltammetry are employed for quantitative monitoring. Recent immunosensors showcase low detection limits and wide linear ranges for measurement of major biomarkers like carcinoembryonic antigen, neuron specific enolase, and cytokeratin fragment 21-1. Emerging biomarkers such as microRNAs and circulating tumor cells have also been targeted. However, reproducibility, selectivity, multiplexing, and integration with point-of-care platforms need improvement for widespread clinical translation. Overall, electrochemical immunosensors hold immense potential for sensitive, affordable lung cancer diagnosis if ongoing efforts can address current limitations.
The Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking
Authors: Le Thang M. , Oba Takeyuki , Couch Luke , McInerney Lauren , Li Chiang-Shan R.
Published: February 2024

Organisms learn to gain reward and avoid punishment through action–outcome associations. Reinforcement learning (RL) offers a critical framework to understand individual differences in this associative learning by assessing learning rate, action bias, pavlovian factor (i.e., the extent to which action values are influenced by stimulus values), and subjective impact of outcomes (i.e., motivation to seek reward and avoid punishment). Nevertheless, how these individual-level metrics are represented in the brain remains unclear. The current study leveraged fMRI in healthy humans and a probabilistic learning go/no-go task to characterize the neural correlates involved in learning to seek reward and avoid pain. Behaviorally, participants showed a higher learning rate during pain avoidance relative to reward seeking. Additionally, the subjective impact of outcomes was greater for reward trials and associated with lower response randomness. Our imaging findings showed that individual differences in learning rate and performance accuracy during avoidance learning were positively associated with activities of the dorsal anterior cingulate cortex, midcingulate cortex, and postcentral gyrus. In contrast, the pavlovian factor was represented in the precentral gyrus and superior frontal gyrus (SFG) during pain avoidance and reward seeking, respectively. Individual variation of the subjective impact of outcomes was positively predicted by activation of the left posterior cingulate cortex. Finally, action bias was represented by the supplementary motor area (SMA) and pre-SMA whereas the SFG played a role in restraining this action tendency. Together, these findings highlight for the first time the neural substrates of individual differences in the computational processes during RL.
Gestión empresarial y tributaria de las criptomonedas en Costa Rica: Una óptica administrativa y financiera
Authors: Sánchez Sánchez Juan Diego
Published: February 2024

The paper presents the conception and epistemological description of the cryptocurrency as good and instrument of use in the costarican operating companies management, which does not present an express regulation in the national law system, considering its use as a profit generator, this under its managerial and financial approach, specifiying the special importance of the accounting record that must be given to both, the investments as well as the income in this virtual currency, depending on business decisions, detailingthe approaches to legal and tax management, as well as the corresponding taxes associated with the generation of lucrative activities associated with the incorporation of cryptocurrencies as part of the business development.
Desarrollo de habilidades blandas en el estudiantado mediante la actividad académica procesos prácticos para la formación de docentes en educación comercial
Authors: Guillén Cordero Norieth , Astorga Aguilar Cristel
Published: February 2024

The purpose of this study is to demonstrate the soft skills that students of Commercial Education’s major at Universidad Nacional (UNA) have developed,through their participation as practicing teachers in the Actividad Académcia Procesos Prácticos para la Formación de Docentes en Educación Comercial,at the Escuela de Secretariado Profesional (ESP) of the Facultad de Ciencias Sociales and División de Educología of the Centro de Investigación y Docencia.To achieve the proposal, a descriptive mixed investigation was carried out, with the participation of students who developed their teaching processesfrom 2016, 2017, 2018 to 2019. It was found out that more than 95 % of the population considers that the teaching practices allowed them to developor enhance various soft skills. The most determining factor for that personal growth, was having to work with populations of elderlies and young people at social risk; in addition, it was possible to highlight the main soft skills acquired by the practicing students. Among them, patience and understanding, problem solving, teamwork, flexibility and adaptability stand out. It was concluded that although the intention of the teaching practices is that the practitioners assume the role of planners and mediators of the teaching and learning process, they must also deal with situations and scenarios that foster an enrichment of the practitioners not only at the academic and didactic level, but also attitudinal.
Implementación de herramientas tecnológicas bajo la modalidad de presencialidad remota por parte del profesorado de la carrera de Administración de Oficinas, Campus Sarapiquí, Universidad Nacional de Costa Rica
Authors: Astorga Aguilar Cristel , Guillén Cordero Norieth , López Cascante Alcides
Published: February 2024

The main purpose of the research is to analyze the experiences of the professors of Administración de Oficinas career at the Universidad Nacional, Campus Sarapiquí, regarding the implementation of technological tools under the modality of virtual presenciality. The research corresponds to a quantitative  exploratory and descriptive study, through an online survey, working with the entire population.  As results, it is determined that there is knowledge anddomain of the use of information and communication technologies (ICT) by the academics, it is identified that the use of these tools facilitates work, promotescollaboration and inclusion, increases the student interest and motivation, and represent an important resource to improve teaching. The most used technology platforms are Zoom (100%), WhatsApp (91.7%), email (75%), Microsoft Teams (58%) and Meet (58%). It is concluded that the teachers have technological competences suitable for the development of pedagogical processes and for the implementation of various technological tools in the virtual classroom setting; and the importance of following up on the results generated due to the changes in the teaching modality in pandemic times, due to the transformation that these can permanently bring in university education.
Influencia de un Corredor Fluvial en la Variación de Elementos Climáticos: El Caso de la Ciudad de Neuquén (Argentina)
Authors: Lopez Micaela , Gentili Jorge Osvaldo
Published: February 2024

This paper aimed to compare the behavior of climatic elements and extreme thermal events between two landscape units of the city of Neuquén, Argentina, for the period 2013-2020. The study involved daily data of minimum temperature (Tmin), maximum temperature (Tmax), and relative humidity (RH) obtained from the meteorological stations "Neuquén Aero" (NA) and "Paseo de la Costa" (PC), referring to the valley (peri-urban area) and the fluvial corridor (riparian environment) respectively. The influence of the riverbank on the daily Tmin and Tmax during Heat Waves (HW) and Cold Waves (CW) in the valley was analyzed using the methodology of the National Meteorological Service. The mean Tmax (Tmin), at annual, seasonal, and monthly resolutions, were lower (higher) in PC. The mean RH values were higher in NA. During the HW, a regulatory effect was exhibited regarding the number of days that the threshold values were exceeded consecutively in the fluvial littoral.
A New Representation for Low Consistency Refining Data
Authors:   Australian Pulp and Paper Institute, Department of Chemical Engineering, Monash University, Batchelor Warren , Elahimehr Ali ,   Pulp and Paper Centre, University of British Columbia, Vancouver BC, Canada, Martinez Mark ,   Pulp and Paper Centre, University of British Columbia, Vancouver BC, Canada, Olson James ,   Department of Mechanical Engineering, University of British Columbia, Vancouver BC, Canada
Published: February 2024

The standard method of representing refining data is to plot fibre or sheet properties as a function of refiner Specific Energy Consumption (SEC), for separate refining trials done at different Specifics EDG Loads (SEL). This approach does not allow for refining outcomes to be predicted when refining at other values of SEL and does not allow for refining conditions to be optimized to satisfy multiple constraints. In addition, the change in fibre properties is determined by the number of impacts on a fibre and the energy used in each impact, while SEC is the product of number and energy used in each impact. The paper describes a new representation of refining data where the two axes of the plot are SEC/SEL, which is proportional to the number of impacts, and 1/SEL, which is proportional to the inverse of the energy used in each impact. Data from refining trials are then plotted as lines of equal value. The paper shows how flow and power limited for a low consistency refiner are represented on such a plot. The utility of the approach is demonstrated with refining data of a CTMP pulp with three different refining plates and three different speeds.
Experimental Study of Filtration of Fiber Suspensions: Part II: Combined PIV and Pressure Drop Measurements
Authors:   Linne Flow Centre, KTH Mechanics, Bellani Gabriele , Bach Roland ,   Linne Flow Centre, KTH Mechanics, Lundell Fredrik ,   Linne Flow Centre, KTH Mechanics, Söderberg L. Daniel ,   Linne Flow Centre, KTH Mechanics; Innventia AB, Stockholm, Sweden
Published: February 2024

The filtration of a fiber suspension has been studied experimentally. Typical application where pressure filtration occurs are: papermaking, air cleaners, production of composite materials, etc. In particular, in papermaking, the quality of the final product depends on the fiber orientation and mass distribution in the filtered materials Micro-variations of there properties can strongly affect the quality of the final product and they can occur during filtration, thus it is important to predict how this can happen. However, this is not an easy task, first because the filtered cake is a non-homogeneous compressible porous media, second because the filtration flow is non-stationary, since the cake is continuously evolving in time. Therefor in this work we focus on the filtration flow through formed steady fiber networks. For each grammage (i.e. mass of fibers per unit area), we simultaneously measure the pressure drop across the network and velocity field on top and below the fiber network using Particle Image Velocimetry (PIV). Compression of the fiber network can also be extracted form the PIV images normalized filtration resistance was found to be decreasing with increasing network thickness, as well as network compressibility. From the PIV data the influence of the formed fiber network on the flow field was analyzed and characteristic scales of the flow structure are quantified.
Quantitative Studies of Ambient Gases in Pulp and Paper Mills and Their Degradation with Photo-catalytic Oxidation Technology
Authors:   State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Tong Xin , Shen Wenhao ,   State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Chen Xiaoquan ,   State Key Laboratory of Pulp and Paper Engineering, South China University of Technology
Published: February 2024

In order to reduce gaseous pollution emissions and achieve the goal of cleaner production in paper industry, in this study, (I) First, the concentrations of four potential compositions of gaseous pollutants, TVOC, HCHO, H2S and CxHy, in the ambient air on 30 sampling sites in 5 pulp and paper mills were analysed. The analysed results were discussed in the following aspects: (a) the levels of four gaseous pollutants on all the sampling sites in five mills; (b) gaseous pollution differences due to different production processes; (c) gaseous pollution comparisons on the common sites. (II) Secondly, the compositions of VOCs in a secondary fiber paper mill were determined with GC-MS method. The main identified substances in the four sites were as follows: (a) waste paper sorting room: alkanes, phenols and esters; (b) paper machine hall: benzene homologues, alkanes, ethers and phenols; (c) vacuum pulp outlet: benzene homologues and phenols; (d) office area: benzene homologues and phenols. (III) Third and last, aiming a the detected formaldehyde and benzene pollutants, a photo-catalytic reactor was developed and its performance with respect to degradation was studied. The performance tests of reactor showed that both formaldehyde and benzene could be completely degraded, but the degradation time for benzene was much longer than that for formaldehyde.
Prediction of Mineral Deposits in Kraft Pulp Bleaching Lines Through Chemical Process Simulation
Authors:   Centre Technique du Papier, Huber Patrick , Nivelon Sylvie ,   Centre Technique du Papier, Ottenio Pascal ,   Centre Technique du Papier, Schelcher Matthieu ,   Centre Technique du Papier, Burnet Auphelia ,   Centre Technique du Papier
Published: February 2024

The general tendency in the pulp industry towards reduced fresh water consumption and minimum effluent causes major deposit problems in mills. Chemical pulp bleach plants are affected by several types of mineral deposits, the most frequent being calcite, calcium oxalate and barite. We present a coupled chemical process simulation of kraft pulp bleaching line, which handles chemical equilibria, together with dissolution and precipitation effects. The simulation could adequately predict formation of mineral deposits throughout a D0(EP)D1D2 bleaching line. Strategies to help reduce formation of calcium oxalate and barite scales could be evaluated. Partial substitution of sodium hydroxide by a magnesium source at extraction stage is anticipated to inhibit formation of calcium oxalate throughout the line. Also, using sulfuric acid instead of spent acid for pH regulation at D0 would reduce but not suppress barite deposits.
Pérdida de stock óseo no osteoporótico en la columna. Denosumab como herramienta de tratamiento e implicancia
Authors: Bazán Pedro Luis , Godoy Adaro Alfredo , Hernández Molina Gilmar Leonardo , Blanco Payano Richard Ángel , Cinalli Micalea
Published: February 2024

Introducción: El denosumab es un anticuerpo monoclonal humano que actúa contra el RANKL, inhibiendo la destrucción ósea mediada por los osteoclastos, así evitando la pérdida de stock óseo; por este motivo, se lo utiliza en el tratamiento de la osteoporosis como agente antiresortivo y está autorizado para el tratamiento del tumor de células gigantes y el mieloma múltiple. Nuestro objetivo fue conocer las indicaciones y contraindicaciones para la pérdida de stock óseo de causa no osteoporótica.
Materiales y Métodos: Revisión sistemática de artículos en inglés publicados en el período 2009-2023. Se incluyeron artículos que indicaran o contraindicaran el uso del denosumab.
Resultados: De un total inicial de 4306 artículos, se analizaron 18 artículos que mostraban consenso en la dosis y los controles con tomografía e indicaban o contraindicaban el uso del denosumab.
Conclusiones: El denosumab está indicado como una buena opción de tratamiento preferente de tumores vertebrales primarios inoperables, para evitar recidivas o demorar las metástasis de tumores primarios o de tumores sólidos, principalmente de mama, próstata y pulmón, y para el compromiso vertebral del mieloma múltiple. El denosumab está contraindicado, por el momento, para las lesiones infecciosas.
Biopsia de sacro: canal de trabajo seguro mediante un sistema tubular
Authors: Bazán Pedro Luis , Baudino Zoya Felipe , Cinalli Micaela
Published: February 2024

No existe un protocolo estandarizado para la toma de biopsias en el sacro. El cirujano, según su experiencia y la sospecha diagnóstica es quien elige el método y la técnica. Se necesita una planificación prequirúrgica para evitar comprometer el sitio de abordaje y disminuir las complicaciones de la técnica, como una muestra insuficiente, daño neurovascular o siembra tumoral. El objetivo de este artículo es comunicar nuestra experiencia en la toma de biopsia con una técnica mínimamente invasiva utilizando un sistema tubular en un tumor de sacro. Presentamos a una mujer de 34 años con sospecha de un tumor primario de sacro (tumor de células gigantes y cordoma principalmente), se planifica el abordaje y se crea un canal de trabajo seguro mediante un sistema tubular y se toman muestras con aguja gruesa guiada por radioscopia.
Conclusión: La toma de biopsia ósea ayudada de un sistema tubular para crear un trayecto seguro es una alternativa para tener en cuenta ante la sospecha de tumores con riesgo de siembra.
In vitro efficacy testing of ivermectin against Tritrichomonas foetus trophozoites
Authors: Sereno-Bruno Estefanía , Fuchs Lumila , Oyhenart Jorge
Published: February 2024

There are no recommended drugs to treat cattle infected with the protozoan Tritrichomonas foetus (TF). Ivermectin, widely used in the treatment of intestinal parasites, was found effective against some protozoa growing in vitro. Here, its effectiveness against a TF line was investigated. Trophozoites were incubated in media with increasing concentrations of ivermectin and mortality was determined after 24 h. Ivermectin killed cells with a mean maximum effective concentration (EC50) of 2.47 μg mL−1. The effective concentration of ivermectin was rather high for a formulation suitable for systemic treatment. However, topical treatment of animals against TF could still be considered and tested.
Development of a testing machine for biaxial testing of soft tissue and biomaterials
Authors:   Sirius University of Science and Technology, Ovsepyan Artur , Salamatova Victoria ,   Sechenov University,   Marchuk Institute of Numerical Mathematics of the RAS, Ramazanov Ali , Dietz Daniel , Vartanov Oleg , Bardynin Dmitry , Klochko Nikita , Podrovsky Alexey , Vasilevsky Yuriy ,   Sechenov University,   Marchuk Institute of Numerical Mathematics of the RAS
Published: February 2024

Knowledge of the mechanical properties of soft tissues and biomaterials is the keystone for predictive modeling in cardio- and endovascular surgery, traumatology and orthopedics, neurosurgery, and the development of tissue-engineering constructs. Needed mechanical properties can be only explored via experimental tests. Therefore, mechanical experiments are forming the foundation of medical decision support systems, which are impossible without adequate mathematical models of the processes involved. Sirius University of Science and Technology has launched the project "Experimental research and mathematical modeling of the mechanical behavior of biomaterials". The goal of the project is to create an infrastructure for experimental study of the mechanics of soft tissues and biomaterials. At this stage, a machine for biaxial testing of soft tissues and biomaterials has been developed and put into trial operation. The developed machine takes into account the features of working with soft tissues: small sample size, maintaining certain environmental conditions to preserve the sample, various types of sample gripping to minimize edge effects and no slippage, non-contact methods for assessing displacement and deformation fields, variability in sample loading protocols. The result of the test is a data set that includes a test report and synchronized output readings of strain gauge, temperature, optoelectronic sensors with high-resolution images. Uniaxial verification tests of acrylic tapes VHB4910 were carried out by the developed machine. The results were compared with data obtained on a commercial dynamic mechanical analyzer RSA-G2 (TA Instruments) for similar materials under the same test conditions. A series of biaxial cyclic experiments were carried out for the pericardium of cattle, the cardiovascular patch Ecofolon PS04/PS01 (JSC NPK Ecoflon, St. Petersburg, Russia), and the GoreTex vascular graft (W.L. Gore and Associates, USA).
Biomechanical models of living tissue
Authors:   Perm National Research Polytechnic University, Bratsun Dmitry , Krasnyakov Ivan , Bratsun Anastasia ,   Perm State Medical University named after academician E.A. Wagner
Published: February 2024

The evolution of living things has led to the emergence of multicellular organ-isms in which cells differentiate, specializing in performing various functions. Cells interact and unite into large groups, forming tissues and transferring the control func-tion to an organ or organism. In fact, the latter is a complex biomechanical system controlled by chemical and mechanical signals. The development of computer tech-nologies and high-speed computing systems gradually leads to the possibility of realistic modeling of the biomechanics of cellular tissue, which reproduces both the averaged dynamics of the tissue and the behavior of cells. Mathematical modeling allows us to study the historical aspects of the evolution of living things, describe the morphogenesis of specific organ-isms, understand the healing processes in organs when they are damaged, consider the appearance of tumors, and develop the tech-nology for artificial tissue growth. This pa-per presents an overview of works devoted to mathematical models of multicellular tissue of living organisms. Specifically, we focus on those models where the cell is a structural unit of a complex system. We classify biomechanical models according to the approach describing the tissue, the method of constructing cells, and the dimension of the tissue formed by the cells. We discuss the interaction forces between cells and topological rear-rangements in tissue during intense cell movement. Finally, we discuss the results of some selected ap-plied research.
Mathematical modeling of corneal hysteresis
Authors:   Institute of Mechanics, Moscow State University, Moiseeva Irina , Stein Alexander
Published: February 2024

Mathematical modeling of the deformation of the eyeball under the external pressure applied to the cornea in a bounded area and gradually increasing and then decreasing according to a given law is performed. This relationship corresponds to the change in applied pressure in the ocular response analyzer (ORA) used in clinic. An approach pre-viously developed by the authors is applied, based on representing the cornea as a soft two-dimensional surface and the scleral region as a zero-dimensional element. Since the process under consideration occurs very quickly (lasting several tens of milliseconds), it cannot be considered as purely elastic. The Voigt viscoelasticity of the cornea is taken into account, the smallness of the strain relaxation time allowing us to consider the solu-tion as a correction to a similar purely elastic problem considered at the previous stage of research. The behavior of two parameters characterizing the asymmetry of the system's response to a symmetrical action is studied. These are the delay time of the moment of maximum flattening of the cornea in the apical region during unloading compared to the moment of its flattening during loading and the difference in external pressures at which these flattenings are reached (corneal hysteresis). Their values obtained from the simula-tion are of the same order as the same values determined experimentally. It is shown that hysteresis increases with increasing strain relaxation time and with increasing maximum external pressure.
Biomechanical analysis of statics and gait of patients with patellofemorale pain syndrome
Authors:   Privolzhsky Research Medical University, Sushin William , Rukina Natalia , Kuznetsov Alexei , Belova Anna , Vorobyeva Olga , Butchenko Artem , Dudorov Evgeniy ,   Research and Production Association "Android Technology"
Published: February 2024

Patellofemoral pain syndrome (PFPS) is a pathology in the knee joint, which is often observed in young active people and manifests itself as pain in the knee and periarticular tissues in the absence of intra-articular pathology of the knee joint. The article presents the results of a biomechanical study of statics and walking in 47 patients with PFPS and 34 healthy individuals. Differences in goniometric parameters were revealed in patients and healthy individuals when walking. It has been demonstrated that in PFPS, biome-chanical disturbances affect both lower extremities. It has been shown that the severity of biomechanical disorders when walking can serve as a predictor of the effectiveness of conservative therapy for PFPS.
Evaluation of fatigue life and osseointegration parameters of carbon-carbon composite material for medical applications
Authors:   E.A. Wagner Perm State Medical University, Astashina Natalia , Loginova Natalia , Rogotnev Aleksandr ,   Perm Federal Research Center UB RAS, Uvarov Sergei , Bannikov Michail , Rapekta Svetlana ,   E.A. Wagner Perm State Medical University, Nikulin Sergey ,   JSC “Ural Research Institute of Composite Materials, Naimark Oleg ,   Perm Federal Research Center UB RAS, Ignatova Anna ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Published: February 2024

The aim of the present work is to study the strength characteristics Carbon fibre-reinforced Carbon (CFRC) material as an osteoimplant under its stepwise loading and to estimate the parameters of osseointegration at the bone-implant interface from the position of histological analysis and mathematical modeling. Fatigue life estimation of materials for implantation and endoprosthesis is based on the study of its "behavior" and determination of the degree of microstructure transformation under different types of cyclic loading using a system for the analysis of acoustic emission under loading. The key parameter in studying the strength of samples from carbon fiber reinforced composite materials under stepwise loading is the determination of the moment of transition of the controlled object into a pre-destructive state. We propose to use the ratio of degree in the equation defining the relationship between the number of acoustic emission events depending on the loading conditions as a key factor in studying the strength of samples made of CFRC under staged loading. When assessing the properties of implant materials, in addition to the study of strength parameters, an important aspect is the determination of the major biomedical characteristics, in particular, the study of bone tissue regeneration processes at the border of the implant-bone block. The osteoinductive activity of materials for plasty of bone tissue defects and endoprosthetics is one of the parameters of the success of reconstructive measures. In this regard, the use of modern methods of histological analysis and mathematical modeling of osseointegration processes of CFRC specimens will allow to predict the effectiveness of their application in clinical practice when replacing bone tissue defects of different localization and in therapy of patients with degenerative-dystrophic diseases requiring endoprosthesis.
Biomechanical aspects of radiation sterilization of composite material “Carbon FC” for medicine
Authors:   Perm National Research Polytechnic University, Oniskiv Vladimir , Sotin Aleksandr , Stolbov Valerii , Nikulin Sergey ,   Ural Research Institute of Composite Materials, Yuzhakova Ekaterina ,   Perm State Medical University named after academic E.A. Wagner
Published: February 2024

The process of volumetric sterilization by gamma-irradiation of composite cellular material actively used for bone defect replacement in medicine is studied. The purpose of this study is to substantiate the necessary doses of gamma-irradiation for sterilization of highly porous carbon material "Carbon-FC" without reducing its mechanical characteris-tics. The technique of volumetric sterilization of the material under study and its testing for microbiological sterility is described. The results of mechanical tests of samples be-fore and after gamma-irradiation are given. Recommendations on selection of ionizing radiation doses providing microbicidal effect without reduction of strength properties during compression of the material under study are given.
Ammonia Sprays for Combustion: A Review
Authors: Giles A. P. , Hao S. , Harper J. , Goktepe B. , Bowen P. J. , Valera-Medina A.
Published: February 2024

Ammonia is a globally transported chemical used for a variety of applications, most notably, the production of fertiliser. Over the past decade, attention has been afforded to the use of ammonia as an energy carrier, coupling global supply of renewable energy to demand regions. Ammonia’s advantages as an energy carrier include its ease of liquefaction and established international transportation routes; overcoming its low reactivity, excessive production of nitrogen oxides and its toxicity remain as challenges. For energy applications, fuel delivery is a critical aspect of effective combustion in boilers, burners and engines. Due to its adaptable phase change characteristics, ammonia fuel may be injected as a liquid or vapour, each with respective advantages or disadvantages. The focus of this review concerns the characterisation of liquid ammonia fuel injection for combustion, including recent research findings from experimental and simulation studies. Liquid ammonia injection can result in the highly dynamic so-called ‘flashing’ or ‘flash boiling’ phenomena. Research findings have been drawn from other related applications such as accidental hazardous releases. Bespoke optical experimental rigs together with diagnostic techniques and two-phase computational fluid dynamics (CFD) simulations have enabled studies of the flashing jets under various initial or final conditions, with recent work also examining ammonia spray combustion. The review concludes with an insight into future trends and requirements for liquid ammonia combustion. Reciprocating engines for marine propulsion are cited as potential early adopters of ammonia energy.
Migration of Platinum Nanoparticles via Volatile Platinum Dioxide during Lean High-Temperature Ageing of Diesel Oxidation Catalysts
Authors: Mulla Shadab , Ross Phillip , Spreitzer Glen , Hess Howard , Aydin Ceren , Moreau François , Chiffey Andrew
Published: February 2024

When platinum-containing diesel oxidation catalysts (DOC) are exposed to high temperatures under lean conditions, the platinum nanoparticles form volatile platinum dioxide on the catalyst surface. The exhaust flow carries the volatile platinum dioxide to the downstream aftertreatment catalyst, such as the selective catalytic reduction (SCR) catalyst, that is responsible for reducing the nitrogen oxides (NOx) emissions and can negatively impact its performance, by promoting the parasitic oxidation of ammonia. Here we investigate the factors such as exposure time, temperature and DOC design characteristics for their impact on the platinum dioxide migration, by characterising the amount of platinum deposited on the SCR catalyst at very low levels (<5 ppm), using inductively coupled plasma optical emission spectroscopy (ICP-OES) fire assay technique. Our results indicate that well-dispersed platinum, not associated with palladium, is most prone to platinum dioxide migration. We also compare several methods to suppress the platinum dioxide migration from the DOC, such as sintering of the platinum nanoparticles, stabilising the platinum nanoparticles via interaction with palladium or covering the platinum nanoparticles with a high surface area capture layer to trap the volatile platinum dioxide.
Malachite green adsorption by Oued Sebou sediment: optimization and desirability analysis
Authors: Mardi Lamyae , Fahoul Youssef , Iboustaten El Mustafa , Bencheqroun Zineb , Belghiti Mohamed , Tanji Karim , Mrabet Imane El , Kherbeche Abdelhak
Published: February 2024

Dye pollution represents an important portion of the pollutants in industrial waste water. Sediment from the Sebou River (Morocco) was utilised in this investigation to adsorb malachite green (MG) in aqueous solution. The optimisation of parameters associated with adsorption was performed by conducting batch adsorption studies and utilising the response surface approach. The adsorption process was accurately described by both the Langmuir isotherm model and the pseudo-second-order kinetic model, and the maximum capacity for adsorption was determined to be 5.98 mg/g. In addition, the adsorption rate was effectively determined by intraparticle diffusion. The thermodynamic parameters determined in the study revealed that the adsorption of MG dye by the sediment was unspontaneous and endothermic in nature. The regeneration of the sediment in three cycles following adsorption was confirmed. The adsorption process of MG dye onto the sediment was found to be driven by two types of interactions – electrostatic and hydrogen (H) bonding. These results indicate that the sediment has the potential to be an effective adsorbent for removing dyestuffs from contaminated industrial effluent. Moreover, the ready availability of the sediment in the area further enhances its suitability for this purpose.
Empoderamiento académico de los estudiantes de secundaria del Colegio Rural Luz de la Esperanza por medio de la estrategia pedagógica integradora “Todos somos uno”
Authors:   Universidad Cooperativa de Colombia, Tarazona Ariza Silvia Andrea , Fajardo Rivera Rubiela
Published: February 2024

Este artículo tiene como objetivo reflexionar críticamente sobre los beneficios de la estrategia pedagógica e integradora con enfoque comunitario denominada “Todos somos uno”; la cual se pensó como medio para fortalecer el rendimiento académico en tres áreas del conocimiento en los estudiantes de todos los grados de secundaria (6° a 11°) del colegio rural Luz de la Esperanza ubicado en el municipio de Tona en el departamento de Santander en Colombia. El objetivo principal de esta propuesta fue la articulación de las acciones desarrolladas por la comunidad educativa de dicha institución con el fin de facilitar los procesos académicos de manera más eficaz optimizando los resultados de evaluación y desempeño escolar en las áreas de lengua castellana, matemáticas e inglés. La implementación de la propuesta sugiere el rediseño curricular de la institución y a la integración consciente y voluntaria de los actores de la comunidad educativa para el beneficio de los estudiantes, puesto que estas prácticas compartidas fomentan el buen desempeño académico de los alumnos.