bluuebunny/crossref_metadata_2025 huggingface dataset:
Haemoglobin Level of Pregnant Women was Associated with History of Anemia During Adolescent Period: Findings from the Indonesia Family Life Survey
Authors: Handari Siti Riptifah Tri , Anies  , Martha Irene Kartasurya  , Sri Achadi Nugraheni
Published: December 2022

Introduction: Low hemoglobin levels in pregnant women are global health problem that adversely affect the mother’s and newborn’s health. There is no study proving the effect of anemia during adolescence in pregnancy, especially in Indonesian population. This study aimed to investigate the effect of anemia in adolescence on the hemoglobin level during pregnancy, using Indonesian Family Life Survey (IFLS) data.
Methods: This retrospective cohort study used the 1997, 2007 and 2014 IFLS data. The hemoglobin levels in adolescents aged 10-18 years were obtained from the IFLS-II data in 1997. Then, the hemoglobin levels during pregnancy from the same individuals were tracked from the IFLS-IV in 2007 and IFLS-V in 2014. Data from 210 subjects were included in the analysis as these subjects had the complete data on hemoglobin levels during adolescence and pregnancy and all other considered confounding variables, such as maternal age, iron protein, vitamin C consumption, education, working status, residence, socioeconomic status, gestational age at data collection, parity, antenatal care, iron supplement consumption. Data was analyzed by T tests, Pearson’s correlation tests and General Linear Model.
Results: The mean hemoglobin levels of pregnant women was 11.23 g/dL with standard deviation 1.271 and the prevalence of anemia during adolescence was 34.3%. There was a significant difference of 0.447 g/dL in the average hemoglobin levels in pregnant women with and without history of anemia during adolescence (p=0.023). The hemoglobin levels in pregnant women also differed among trimesters of gestational age (p=0.001). After being controlled for vitamin C and protein consumption, anemia status during adolescence still has a significant effect on lowering hemoglobin level during pregnancy.
Conclusion: Anemia during adolescence negatively impacts pregnant women's hemoglobin levels. Prevention programs for anemia in pregnant women should be started from adolescence period.
Intensifying self-awareness of undergraduate students toward hypertension risk factors through health education
Authors: Relawati Ambar , Maulidawati Dewi
Published: December 2022

Introduction: Hypertension in adolescents’ risk factors include foods that contain high sodium, lack of physical activity, stress, obesity, alcohol consumption, and smoking. Order to prevent hypertension incidence in adolescents by increasing self-awareness through the provision of health education. This study aimed to determine the health education effect regarding the risk factors of hypertension (stress and sodium diet) on the self-awareness of undergraduate students in Yogyakarta.
Methods: This study was a quantitative study with a quasi-experiment pretest & posttest with a control group design. The hypertension self-awareness questionnaire was used in this study and the results will be classified into two groups (the control and the intervention group). The sample obtained in this study was 54 respondents. The Mann-Whitney U and Wilcoxon Signed Rank test was done in this study.
Results: It showed that there were significant differences in the intervention group and control group. There were significant differences in results found before and after health education (significance value 0.000), while the result for the control group is 0.06, which indicates that there were no significant differences before and after the leaflet.
Conclusions: It can be concluded that health education regarding risk factors for hypertension (stress and a high sodium diet) can increase self-awareness for undergraduate students in Yogyakarta.
Carotid intima-media thickness in the first descendant of coronary artery disease patients with Apolipoprotein-E4 genotype
Authors: Prayogo Ahmad Rafi Satrio , Yunita Elvira , Yolanda Rachmawaddah , Fahri Ismir , Lestari Novriantika , Asteria Marisadonna , Nasution Ahmad Azmi , Jusup Endang  , Sipriyadi  , Djatmiko Ellen Maidia
Published: December 2022

Introduction: Carotid intima-media thickness (CIMT) is a predictor marker of subclinical atherosclerosis that can be measured by ultrasound technique. The clinical symptoms of atherosclerosis usually begin with the thickening of the carotid artery walls. Polymorphism in Apolipoprotein E4 (APO-E4) is considered to be an important genetic determinant of atherosclerosis and Coronary Artery Disease (CAD). The genetic role of APO-E4 on plasma lipid has shown that the APO-E4 allele is associated with increased plasma LDL and total lipid concentration. The main objectives of this study were to identify genotype polymorphisms of the APO-E gene and measure the thickness of the carotid intima in subjects with APO-E4 polymorphisms in the first descendant of coronary heart patients.
Patients and methods: A cross-sectional study design was used to determine the polymorphism of the APO-E4 genotype in the first descendant of CAD and non-CAD groups. There were 21 samples in each group. Gene polymorphism examination was carried out by PCR and the CIMT was measured with doppler ultrasound.
Results: The result showed that 21.4% of subjects had polymorphism of the APO-E4 genotype with a significant difference between CHD and non-CHD group. This data shows that the APO-E4 genotype is more dominant in the first descendant of patients with CHD when compared to non-CHD parents. The mean values of CIMT ini right and left-sided carotid arteries among APO-E4 genotype and non-APO-E4 genotype were 0.4743 mm vs. 0.4195 mm and bivariate analysis showed a significant difference with a P-value of 0.017. This shows that there is a significant difference in the thickness of the carotid intima in the first descendant of subjects who have the APO-E4 genotype and those who do not.
Conclusion: The APO-E4 gene polymorphism was more dominant in the first descendant of CAD patients with a higher CIMT mean value.
Evaluation of dermoscopic photoaging score among multiethnic in Medan, Indonesia
Authors: Jusuf Nelva Karmila , Putra Imam Budi , Muslim Medina
Published: December 2022

Background: Skin is considered a reflection of a person's appearance, so it is normal if many people try to take care of their skin, especially facial skin, and retard the aging process. Dermoscopy is a quick, non-invasive technique that allows physicians to observe the skin. Different ethnic groups may show different signs of aging on the face. Medan is a multiethnic city and thus might show facial skin aging differently. This study aimed to evaluate facial skin aging through the Dermoscopic Photoaging Scale (DPAS) and assess the relationship between DPAS, Glogau and Fitzpatrick scales among various ethnic groups in Medan, Indonesia.
Subjects and Methods: This cross-sectional study enrolled 155 subjects from 10 ethnicities in Medan. The examination of facial aging is based on DPAS using 11 criteria, the Glogau scale, and the Fitzpatrick skin type.
Results: Malay and Karonese got the highest DPAS score. There was a significant difference between DPAS, Glogau, and Fitzpatrick in age (p = <0.001,<0.001 and 0.032), and Fitzpatrick scores in ethnicity (p <0.001). There was a strong and significant correlation between DPAS and Glogau scores (p < 0.001, r = 0.748), while DPAS and Fitzpatrick's scores showed a moderate and significant correlation (p < 0.001, r = 0.288).
Conclusion: The highest DPAS scores were found in the Malay and Karonese ethnic groups. There were significant differences between DPAS, Glogau, and Fitzpatrick in age and Fitzpatrick scores in ethnicity. There was a strong and significant correlation between DPAS scores and the Glogau scale and a moderate and significant correlation between DPAS and Fitzpatrick scores in various ethnic groups.
Clinicopathological characteristics and possible risk factors for extrauterine metastases in endometrial carcinoma
Authors: Teuku Mirza Iskandar  , Very Great Eka Putra  , Ediwibowo Ambari  , Endy Cahyono  , Lubena
Published: December 2022

Introduction: Extrauterine metastases often occur in patients with advanced stages of endometrial carcinoma. Retroperitoneal lymph nodes and pelvic lymph nodes are the most common metastatic sites for endometrial carcinoma, while distant metastases, including those to the lung, liver, and brain, are uncommon. This study compares the characteristics of endometrial carcinoma with or without extrauterine metastases and evaluates risk factors associated with extrauterine metastases.
Methods: A retrospective analytical study of 155 women with a history of endometrial cancer
following complete surgical staging treatment from January 2017 to December 2021 at Dr. Kariadi General Hospital Semarang. All data were obtained using medical records. The clinical and pathological characteristics were compared using the Unpaired T-test and Chi-Square test. Multivariate logistic models were performed to estimate the odds ratio (OR) and 95% CI to analyze independent risk factors for extrauterine metastases.
Results A total of 155 endometrial cancer patients were included in this study. Of these, 77 patients have extrauterine metastases (49.67%). The most common site for extrauterine metastases is ovarian metastases (26.5%). Using univariable and bivariate analysis, tumor differentiation grading (OR=3.69, p=0.027) and myometrial invasion (OR=2.84, p=0.027) were the two risk factors associated with extrauterine metastases. 
Conclusion: There were significant differences in clinicopathological characteristics between the two groups with and without extrauterine metastases. Tumor differentiation grading and myometrial invasion were two independent risk factors.
The role of neuron-specific enolase (NSE) and S100B protein in the incidence of acute postoperative cognitive dysfunction (POCD) in geriatric patients receiving general anesthesia
Authors: Alvin Muhammad , Airlangga Prananda Surya , Kusuma Edward , Kriswidyatomo Prihatma , Lestari Pudji , Setiawati Yunias
Published: December 2022

Introduction: Postoperative cognitive dysfunction (POCD) following general anesthesia is frequent among geriatric patients worldwide. Neuroinflammation and neuronal injury have been associated with the incidence of POCD. Some biomarkers of brain damage including neuron-specific enolase (NSE) and S100B protein have been widely studied; however, their association with the incidence of POCD is still controversial. This study aimed to assess the correlation of serum NSE and S100B levels with the incidence of POCD among geriatric patients receiving general anesthesia.
Methods: A prospective cohort study was conducted among geriatric patients receiving general anesthesia at Dr. Soetomo Hospital, Surabaya from July to October 2022. The Montreal Cognitive Assessment (MoCA) INA instrument was used to assess POCD, and enzyme-linked immunosorbent assay (ELISA) was used to quantify the levels of serum NSE and S100B. Spearman’s rank correlation was implemented to identify the correlation of MoCA INA scores with the levels of NSE and S100B. Mann-Whitney analysis was used to determine the association between NSE and S100B levels with the incidence of POCD. A p-value of ≤0.05 was considered statistically significant.
Results: A total of 48 patients were enrolled in the study and 16.7% of them had POCD. Spearman’s correlation test suggested no significant correlation between MoCA INA score with serum NSE level (rs:-0.095; p=0.522) and S100B level (rs:-0.213; p=0.146). Mann-Whitney analysis indicated no significant difference in the NSE and S100B levels of patients with and without POCD (p=0.3470 and p=0.097, respectively).
Conclusion: There was no significant association between NSE and S100B levels with the incidence of POCD among geriatric patients receiving general anesthesia during elective surgeries at Dr. Soetomo Hospital, Surabaya.
Variation of conus medullaris location based on magnetic resonance imaging of the lumbar spine in Indonesia: A study at Dr Soetomo General Academic Hospital, Surabaya, Indonesia
Authors: Adhiatma Aria , Waloejo Christrijogo Sumartono , Wirabuana Belindo , Rahardjo Eddy
Published: December 2022

Introduction: Recognition of conus medullaris position, contains lumbosacral plexuses which supply motor and sensory innervation to the whole lower limb, pelvic and perineal areas, is critical to avoid injury due to lumbar procedures, such as spinal anesthesia and lumbar punctures. This study aimed to investigate the position of conus medullaris among Indonesians through magnetic resonance imaging (MRI) of the lumbar spine at Dr. Soetomo General Academic Hospital in order to minimize the risk of conus medullaris trauma.
Methods: A retrospective study was conducted to investigate the conus medullaris level and its correlation to gender and age Indonesian patients. The data were collected from lumbar MRI at Dr Soetomo General Academic Hospital during January 2020 and December 2021. The level variations of conus medullaris were recorded and determined as the highest, lowest and most common location descriptively.
Results: A total of 257 patients (126 male and 131 female) were included. The highest level of conus medullaris was in T11-T12 vertebrae (five patients). There were 12 patients in T12 vertebrae, T12–L1 in 86 patients, L1 in 62 patients, L1–L2 in 76 patients, and L2 in 12 patients. The lowest level was in between L2 and L3 vertebrae in 4 patients. Gender and age had no association with conus medullaris level.
Conclusion: The lowest level of conus medullaris was in between L2 and L3 vertebrae. The lumbar procedure such as punctures should be done below the L3 to avoid conus medullaris puncture trauma.
Analysis of the effectiveness of sphenopalatine ganglion block on fentanyl needs in endoscopic endonasal surgery as measured by qNOX score
Authors: Sumitro Agil Rumboko , Salinding Agustina , Susila Dedi , Sutikno Budi
Published: December 2022

Introduction: Endoscopic endonasal is one of the technological advances used as a supporting examination for diagnosis and therapy. This procedure is often used to evaluate medical problems of the nose and sinuses, such as functional endoscopic sinus surgery or FESS (functional endoscopic sinus surgery), turbinoplasty, and septoplasty. Surgery can be difficult to manage because there is often bleeding due to the large supply of blood vessels in the sinus area. This study aimed to investigate differences in qNOX scores and fentanyl requirement in patients undergoing endoscopic endonasal surgery with sphenopalatine ganglion block.
Methods: The total sample was 18 patients, with each treatment 9 patients. Patients were divided into two groups: group 1 patients who received sphenopalatine ganglion block with 0.75% ropivacaine and group 2 patients who did not receive a block. The selection of patients in groups 1 or 2 was done randomly (simple random) using lottery numbers and with a single blind.
Result: Statistical analysis showed significant differences in intraoperatively in qNOX scores at the 5th, 10th, 15th and 20th minute and the mean qNOX score in the first 1 hour between the control group and the sphenopalatine ganglion block group. Significant differences were also found in fentanyl requirement between the control group and intraoperative sphenopalatine ganglion block, where fentanyl requirement was lower in the treatment group.
Conclusion: The sphenopalatine ganglion block is a useful adjunct in patients undergoing endoscopic surgery and may reduce the need for fentanyl. In addition, it can provide a more stable qNOX score
Comparation of intestinal fatty acid binding protein (I-FABP) level between pre- and post-surgery and its associated determinants in patients with microscopic otorhinolaryngology surgeries
Authors: Atmajaya Yuda , Wibowo Mohammad Satriyo , Airlangga Prananda Surya , Maulydia  , Kriswidyatomo Prihatma , Yusuf Muhtarum , Utomo Budi
Published: December 2022

Introduction: Intestinal fatty acid binding protein (I-FABP) is expected could be used as predictor of tissue hypoperfusion. This study sought to compare the level of I-FABP between pre- and post-surgery and its associated determinants in patients with otorhinolaryngology surgeries using general anesthesia with controlled hypotension (CH) technique.
Methods: We did a cross-sectional study was conducted among patients that underwent elective surgeries at Dr. Soetomo in Surabaya, Indonesia. Those who underwent surgeries using general anesthesia with CH technique were recruited in the study. I-FABP levels were measured using ELISA 1 hour before the surgery and 30 minutes after general anesthesia ended. Fisher's exact test and Mann-Whitney test were used to determine the determinants associated with changes of I-FABP level between pre- and post-surgery.
Results: A total of 31 patients who underwent the surgeries with general anesthesia and CH technique were included in this study. The median of I-FABP level pre- and post-surgery was 0.639 ng/mL to 0.779 ng/mL, respectively suggesting there was a significant increase of I-FABP level after the CH technique (p<0.001). Gender and ASA score did not associate with I-FABP level changes pre- and post-surgery with p=0.333 and 0.060, respectively. Age, BMI did not associate with changes of I-FABP level between pre- and post-surgery (p=0.747 and p=0.051, respectively). Surgery duration, anesthesia duration, systolic, diastolic and MAP all also had no association with changes of the I-FABP level with p>0.05.
Conclusion: The levels of I-FABP increased significantly in post-surgery in patients with otorhinolaryngology surgeries using general anesthesia with CH. Further studies are warranted to confirm this result with bigger sample size.
Relationship between Vitamin D Levels and Platelet Function in the Elderly Patients with Coronary Heart Disease
Authors: Limantoro Charles , Catharina Suharti  , Trilaksana Nugroho  , Friska Wilda Wijaya
Published: December 2022

Introduction: Coronary Heart Disease (CHD) is a degenerative disease caused by fat accumulation and chronic inflammation. The elderly have a significant CHD risk due to the prevalence of vitamin D insufficiency and decreased platelet function, influencing the inflammatory response in this population. Therefore, this study aims to assess the relationship between vitamin D levels and platelet function measured by the mean platelet volume (MPV) and P-Selectin serum levels of CHD patients.
Method: The cross-sectional design was carried out on stable CHD patients aged 60-75. Meanwhile, vitamin D, MPV, and P-Selectin were taken through venous blood, and an ELISA examination was performed to determine their levels in serum. A correlation test using the Pearson product-moment was also conducted between vitamin D and platelet function.
Result: The subjects involved were 45 male and 16 female at 73.8% and 23.2%, respectively. The highest risk factor was dyslipidemia found in 45 (73.8%) and all subjects (100%) received statins. This study showed no correlation between vitamin D levels and MPV levels (p= 0.094) and P-Selectin (p=0.362).
Conclusion: Vitamin D levels are not associated with platelet function levels (MPV and P-Selectin) in elderly patients with CHD.
Silver sulfadiazine as the topical treatment for giant omphalocele: a case report
Authors: Mastuti Ni Luh Putu Herli , Etika Risa , Utomo Martono Tri , Angelika Dina , Handayani Kartika Darma
Published: December 2022

Background: Major omphalocele is defined as an abdominal defect greater than 5 cm with the presence of the liver and most parts of the bowel in the sac. The management remains challenging for pediatricians and surgeons with remarkably high mortality. Reports about topical agents/dressing used as escharotic therapy, such as silver sulfadiazine, povidone-iodine, topical antibiotics, or honey, have been published with different results. Continued application of a thick layer of silver sulfadiazine on the omphalocele surface is needed to promote eschar formation and neo-epithelialization.
Case description: A term, 2700-gram newborn male infant presented with abdominal defect and herniated abdominal contents covered by a membranous sac containing liver that is widely known as omphalocele. A thick layer of silver sulfadiazine was applied repeatedly onto the omphalocele sac to promote epithelialization and successfully reduce the sac diameter. The patient showed a positive outcome as it reduced the omphalocele size after nine days. The patient family has been educated about the continued application of silver sulfadiazine. Although non-operative delayed treatment has lower mortality rates and better clinical outcomes, the patients should wait for the reconstruction surgery for a long time.
Conclusion: Conservative treatment with silver sulfadiazine is safe and shows satisfying results to the giant omphalocele.
Improved abdomen muscle activity with interferential current therapy in cerebral palsy with constipation: a randomized controlled trial study
Authors: Verayunia Shofie Sabatin , Wulan Sri Mardjiati Mei , Handajani Noor Idha , Andriati  , Kusumawardani Martha Kurnia , Darma Andy , Ranuh Reza Gunadi , Melaniani Soenarnatalina
Published: December 2022

Background: Children with cerebral palsy (CP) often experience many comorbidities, such as constipation. Pain and discomfort that often accompany constipation have an impact on behavior and decrease quality of life. Abdominal muscle weakness can cause a low increase in intra-abdominal pressure so that the expulsive force during defecation is not adequate. The aim of this study was to evaluate the addition of interferential current (IFC) therapy on standard therapy (lactulose) on abdominal muscle activity in children with cerebral palsy (CP) with constipation.
Methods: This research is a true experimental study with pre and post-test randomized control group design. Subjects were 18 children with CP who were constipated according to the ROMA IV criteria, which were divided into two groups, namely the control group who received standard therapy (lactulose) and the intervention group who received lactulose plus IFC therapy with a frequency of 4000-4100 Hz, duration 20 minutes, 3 times a week for 1 month. The parameters evaluated in this study were the value of abdominal muscle activity at rest and during contraction. Measurements were carried out twice, before and one week after the completion of the IFC therapy series. Data were analyzed computerized with SPSS v20.0.
Results: There was a significant decrease in abdominal muscle activity at rest (P= .024) in the treatment group, while there was an insignificant increase in the control group (P= 0,266).
The abdominal muscle activity during contraction in the treatment group showed a greater increase (P= 0.730) than in the control group (P= 0.831). The effect size in the treatment group is 0.2, which means it has a small effect, while in the control group is 0.1, which means it has no effect.
Conclusion: The addition of IFC to standard therapy (lactulose) can improve abdominal muscle activity so that IFC can be an alternative supporting therapy in cerebral palsy with constipation to provide a good clinical response.
Curcumin, a potential oral herbal male contraceptive: a review article
Authors: Nora Hilwah , Rajuddin  , Hafizudin  , Suhanda Rachmad , Indirayani Ima
Published: December 2022

Background: Worldwide, the population explosion and unintended pregnancies pose serious health issues. The family planning program is a vital element due to reducing population growth. Demographic data and family planning in Indonesia report that contraceptive use rates are 93.66% for women and 6.34% for men. Men's participation in family planning programs remains low, with options limited to vasectomy and condoms. Limited contraceptive options may explain the low participation rate. WHO recommends traditional medicine as a cost-effective substitute for manufactured medicines. The primary ingredient in turmeric, Curcumin, has antiviral, antibacterial, anti-inflammatory, and anticancer activities. In both animal and human clinical trials, it has demonstrated a lack of toxicity. Little research has been done on how it affects the male reproductive.
Objective: This article reviews the literature regarding the effects of Curcumin in Curcuma Longa on male fertility.
Conclusion: Curcumin in Curcuma Longa causes noticeable changes in the male reproductive system that reverse when treatment is discontinued. Therefore, Curcumin may potentially control male fertility as a male contraceptive.
Radiotherapy for primary angiosarcoma of the breast: a case report
Authors: Marlina Yoke Surpri , Novirianthy Rima , Yus Teuku Muhammad
Published: December 2022

Background: Primary breast angiosarcomas are very rare type malignant breast tumor. It may have an insidious clinical onset, presenting as a painless, often discrete palpable mass that grows rapidly. The ranged age of disease is 20-50 years.
Case description: We report a case of a young woman with palpable and painless mass of her left breast.  Based on radiological findings with mammography and MRI examination reported as malignant mass of the left breast suspected angiosarcoma. Pathological confirmation post-surgery reported a well-differentiated angiosarcoma that arose primarily in the left breast. Patient treated with simple mastectomy followed by whole breast radiotherapy. External beam radiotherapy delivered using 3DCRT with FIF technique, prescribed dose 60Gy in 30 fractions within 6 weeks.
Conclusion: There is no established standard treatment for primary angiosarcoma of the breast. Mastectomy remains the mainstay of treatment. Adjuvant radiotherapy appears to improve local control.
SISTEM KERJA DENGAN PENDEKATAN ERGONOMI TOTAL MENGURANGI KELUHAN MUSKULOSKELETAL, KELELAHAN DAN BEBAN KERJA SERTA MENINGKATKAN PRODUKTIVITAS PEKERJA INDUSTRI GERABAH DI KASONGAN, BANTUL
Authors: Purnomo Hari , Manuaba Adnyana , Adiputra Nyoman
Published: December 2022

Era globalisisi saat ini, industri kecil dituntut untuk meningkatkan produktivitasagar dapat bersaing untuk kelangsungan hidup. Dalam upaya meningkatkan produktivitaskerja perlu adanya usaha yang kondusif untuk mengoptimalkan sistem kerja. Peningkatanproduktivitas akan tercapai jika semua komponen dalam sistem kerja dirancang secaraergonomis. Sistem kerja pada industri gerabah di Kasongan Bantul banyak melibatkanaktivitas fisik, sehingga perlu sistem kerja yang ergonomi untuk dapat meningkatkanproduktivitas. Pada penelitian ini dilakukan perbaikan sistem kerja pada industri gerabahdi Kasongan dengan pendekatan ergonomi total. Rancangan penelitian yang digunakanadalah rancangan eksperimental yang menggunakan randomized pre and post-test controlgroup design dengan jumlah sampel 14 orang untuk masing-masing kelompok. Hasilpenelitian menunjukkan bahwa sistem kerja dengan pendekatan ergonomi total dapat : (a)menurunkan keluhan muskuloskeletal pekerja sebesar 87,8% ; (b) menurunkan kelelahanpekerja sebesar 77,5% ; (c) menurunkan beban kerja pekerja sebesar 21,55 denyut/menitatau sebesar 21,69% ; (d) menurunkan risiko cedera di tempat kerja sebesar 10,65% ; (e)meningkatkan produktivitas pekerja sebesar 59,49% ; dan (f) meningkatkan pendapatanpekerja sebesar 23,81% dan meningkatkan pendapatan perusahaan sebesar 76,19%.
COMBINATION OF TEMPEH AND CARROT PREVENT ATHEROSCLEROSIS WISTAR RAT: Indicated by Increase of HDL and Total Antioxidant, Decrease LDL, F2-Isoprostan, and IL-6
Authors: Ari-Agung I G. A. , Suryadhi N. T. , Mantik N. A. , Suter I K. , Partama I. B. G.
Published: December 2022

Coronary heart disease (CHD) is the leading cause of death, either in developed and developing countries. The disease is stimulated by the present of atherosclerosis. This study aims to investigate supplementation of combinedÂ tempehÂ M-2Â and carrot to prevent atherosclerosis wistar rat by increases HDL and TAC, decreases LDL, F2-Isoprostan, and IL-6.Â  This was a true experimental study with the factorial completely randomized post-test only control group design. Â variables such as KN (standard feeding / pellets (50 g / kg bw / day), KP: pig lubrication: pellets (1: 9) (50 g / kg bw / day), T : lubrication pig: pellets (1: 9) with tempehÂ M -2Â (20 g / kg bw / day), W: pig lubrication: pellets (1: 9) with carrots (20 g / kg bw / day), and TW: pig lubrication: pellets (1: 9) with tempehÂ M-2Â (20 g / kg bw / day), and carrots (20 g / kg bw / day).Â  Dependent variables in this study are serum HDL,serum TAC, LDL serum, urine F2-Isoprostan, and plasma IL-6 (with Elisa Method). Data were analyzed using the F test (two-way ANOVA), followed by LSD test. Descriptive research was also conducted in this study in order to find out the change of aortic histopathologic. The highest average levels of HDL, TAC contained on TW, which respectively amounted 68.640 Â± 0.50 mg / dl, 1.454 Â± 0.01 nM / mL. It showed highly significant differences (p<0.01) in the various treatments.Â  TW treatment showed highly significant interaction effect (p<0.01) were observed for all parameters except for HDL. Average levels of LDL, F2- Isoprostan, and IL-6 Â lowest in the treatment TW, which respectively amounted Â 20.718 Â± 1.33 mg / dl, 0.720 Â± 0.065 ng / dl, 35.328 Â± 1.000 pg/dl, showed highly significant differences (p<0.01) in the various treatments. It can be concluded that supplementation with a combination of tempehÂ M-2Â with carrots give the best effect, can increases HDL and TAC, and can decreases LDL, F2-Isoprostan, IL-6 significantly, and may change the hystopathologyÂ  structure of aorta from endotel dysfunction to become normal.
Karakteristik pasien gangguan bipolar yang dirawat di RSUP Sanglah Denpasar periode April 2016 – Maret 2017
Authors: Sugiyanto Rose Widanti , Diniari Ni Ketut Sri , Ariani Ni Ketut Putri
Published: December 2022

Background: Bipolar disorder is a brain disorder that changes the mood, though, energy and behavior. These abnormalities are implicated by manic, hypomanic, depression and mixed episodes. The incidence of bipolar disorder is not too high, ranging from 2% -4%. However, the incidence of bipolar disorder is more prolonged and more increase.Aim: This study aims to determine the characteristics of bipolar disorder treated in RSUP Sanglah Denpasar in the period April 2016 - March 2017.Method: This study is a descriptive retrospective design which is set at the General Hospital (RSUP) Sanglah Denpasar. Data obtained in the form of secondary data of patient's medical record on period April 2016 - March 2017. Data were analyzed by using SPSS program.Result and Conclusion: Of the 15 patients, the average age of the patient is 31-40 years (46.7%) with the first onset suffered on average 31-40 years old (40%), the most female (66.7% ), senior high school education (86.6%), unmarried marital status (53.3%), private employment (66.7%), bipolar type affective disorder bipolar episode now manic with psychotic symptoms (60%), none family history (80%), stressor of work problems (66.7%) with comorbid psychiatry (6.7%) and some with non-psychiatric comorbid (6.7%), substance abuse (26.7%), and most pharmacological therapy with anticonvulsant antipsychotic combination (20%) and non-pharmacological one by suggestive communication (40%) as well. Gangguan bipolar adalah  kelainan otak yang ditandai dengan perubahan  mood, pemikiran, energi dan tingkah  laku. Kelainan ini ditandai dengan episode  manik, hipomanik, depresi dan campuran. Dapat dikatakan insiden gangguan bipolar tidak tinggi, berkisar 2%-4%. Namun, angka kejadian gangguan bipolar terus meningkat dari tahun ke tahun.Tujuan: Untuk mengetahui karakteristik pasien gangguan bipolar yang dirawat di RSUP Sanglah Denpasar periode April 2016 – Maret 2017.Metode: Penelitian ini berupa desain deskritif restrospektif yang dilakukan di Rumah Sakit Umum Pusat (RSUP) Sanglah Denpasar. Data yang diperoleh berupa data sekunder rekam medis pasien periode April 2016 – Maret 2017. Data dianalisis dengan menggunakan program SPSS.Hasil dan Simpulan: Dari 15 pasien, rata-rata berusia 31- 40 tahun (46,7%) dengan onset pertama kali menenderita rata-rata berusia 31-40 tahun (40%), jenis kelamin terbanyak adalah perempuan (66,7%), pendidikan terakhir SMA (86,6%), status pernikahan belum menikah (53,3%), pekerjaan swasta (66,7%), tipe bipolar gangguan afektif bipolar episode kini manik dengan gejala psikotik (60%), tidak ada riwayat keluarga (80%), stressor masalah pekerjaan (66,7%) dengan komorbid psikiatri (6,7%) lalu sebagian dengan komorbid non psikiatri (6,7), penyalahgunaan zat (26,7%), dan terapi farmakologi terbanyak dengan kombinasi antipsikotik antikonvulsan (20%) serta terapi non farmakologi dengan pemberian komunikasi informasi edukasi (40%).
Hubungan konsumsi kopi hitam terhadap tekanan darah pada perokok dewasa
Authors: Naraswari Ni Made Sarah Manacika , Sutadarma I Wayan Gde , Dewi Ni Nyoman Ayu
Published: December 2022

Background: Unhealthy lifestyles such as smoking and consuming coffee can affect blood pressure.Aim: The study aims to evaluate the association between black coffee consumption and hypertension.Method: This study design was cross-sectional with 93 participants. Data taken from questionnaire measurements and blood pressure measurements at a time.Results and conclusion: The results showed 79.6% had abnormal blood pressure and 20.4% had normal blood pressure. In this study male smoker workers who consumed black coffee were statistically related to blood pressure (p <0.05). Pola hidup yang tidak sehat seperti merokok dan mengkonsumsi kopi dapat mempengaruhi tekanan idarah.Tujuan: Untuk mengevaluasi hubungan konsumsi kopi hitam dan tekanan darah.Metode: Desain penelitian ini cross-sectional dengan 93 peserta sampel. Data yang diambil berasal dari pengukuran kuisioner dan pengukuran tekanan darah sewaktu.Hasil dan simpulan: Terdapat 79,6% sampel memiliki tekanan idarah tidak normal dan 20,4% memiliki tekanan darah normal. Dalam penelitian ini pekerja laki-laki perokok yang mengkonsumsi kopi hitam berhubungan secara statistik dengan tekanani darah (p < 0,05).
Hubungan kualitas hidup dan faktor resiko pada usia lanjut di wilayah kerja puskesmas Tampaksiring I Kabupaten Gianyar Bali 2015
Authors: Wikananda Gede
Published: December 2022

Aging is a process characterized by a wide range of changes that occur in an individual, both mentally, socially, and physically. Along with increasing age, it is associated with changes in the quality of life of the individual. Unfortunately, these changes tend to be associated to a less good. It is associated with various factors, such as changes in socio-economic environment in the sense to stop working due to retirement, the inability to take part in society, loss of family and friends, the dependence of physical needs, a decrease in physical conditions, and lack of attention from people around, especially families in meeting the needs of physically and mentally the elderly. This condition can cause severe morbidity for the elderly if not handled properly, causing a bad impact on quality of life for the elderly which leads to increased morbidity and mortality. Based on these problems, the authors conducted a study to determine the level of quality of life for the elderly associated with various risk factors in the elderly in Puskesmas Tampaksiring I as a step advocacy in improving the programs of promotion and prevention in dealing with problems of the elderly in Puskesmas Tampaksiring I.Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â  This study is a cross - sectional descriptive study . Samples are elderly aged 60 years and older with a sample size of 90 people selected randomly in Tampaksiring Village and Village Sanding District Tampaksiring Gianyar regency using multistage random sampling technique. Data were obtained through interviews with respondents using a structured questionnaire.Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â  The results showed that the lack or poor quality of life associated with the age group > 70 years, male gender, low education levels, status is not married or a widow / widower, did not work, the level of monthly income is low, and the presence of > 2 chronic disease.
Maternal social determinants of stunting events in Kulon Progo, Yogyakarta
Authors: Ayu Suci Musvita , Sofiana Liena , Wardani Yuniar , Haryanto Yus
Published: December 2022

Background and purpose: Kulon Progo District is one of the 100 priority districts in Indonesia for stunting program with a prevalence of 22.65%. The purpose of this research is to identify association between mother's education, family income and exclusive breastfeeding history with stunting events in Kulon Progo District, Yogyakarta.Methods: This research used a cross sectional design which conducted in Kulon Progo District, Yogyakarta. There were 729 children aged 0-59 months recorded in the integrated service post (posyandu) who met the inclusion criteria. Data collection was conducted using a questionnaire for children and mothers’ characteristics, while stunting status was retrieved from the growth monitoring card. Data analysis was conducted using Chi-Square test.Results: Children in the survey were 53.77% boys and around a quarter (24.69%) were at 25-36 months old. The majority of the mothers (72.98%) were between the ages of 26 and 35 years with high school education (67.35%) and most of them did not work (82.17%). Children with lower maternal education are less likely to experience stunting (PR=0.751; 95%CI: 0.593-0.952; p=0.013), and those from lower income family have almost five fold increased chance of stunting (PR=4.562; 95%CI: 2.643–7.874; p<0.001). Whilst for history of exclusive breastfeeding, the association was not statistically significant with stunting (PR=0.795; 95%CI: 0.529–1.196; p=0.239)Conclusion: There is a relationship between maternal and family education with the probability of stunting, while there is 20% reduced chance of stunting if children were breast fed although it was not statistically significant. Improving maternal awareness on stunting is essential for stunting management programs.
Eurovision 2021 on the Websites of Russian TV Channels
Authors:   Lomonosov Moscow State University, Bukhareva Arina , Kruglova Ludmila A. ,   Lomonosov Moscow State University
Published: December 2022

The article examines publications about the international music contest “Eurovision-2021”. The work contains a comprehensive analysis of more than a hundred publications of six Russian TV channels (Channel One, Russia 1, NTV, Muz-TV, Pyatnitsa, Yu) in 2021, an attempt is made to typify publications about Eurovision 2021, as well as a comparative analysis of this content on different channels is provided. The authors come to the conclusion that the international competition is more interesting for the federal “big three” than for youth entertainment channels, and the volume of publications, tone, and thematic range depend on the “proximity” of the channel to Eurovision.
“The Moralizing Catechism of True Freemasons” by I. V. Lopukhin as a Way of Forming the Masonic Ideal of Man
Authors:   Ural Federal University, Prikazchikova Elena E.
Published: December 2022

The article analyzes the problems of I. V. Lopukhin’s “Moralizing Catechism of True Freemasons” as part of the treatise “The Spiritual Knight, or the Seeker of Wisdom” (1791). “The Moralizing Catechism” is considered to be a text that reflects the way of formation of the Masonic ideal of a person with a focus on the philosophy of Rosicrucianism. The purpose of the article: to prove that the answers to 40 questions of the “Moralizing Catechism” are the ethical basis of I. V. Lopukhin’s work. Based on the methods of ideological-thematic and subcultural analyses, the author of the article highlights the following topics raised by I. V. Lopukhin: proof of the Christian origin of Masonic teaching, description of the “scientific” knowledge of the Christian mysteries by Freemasons, the process of removing the “Old Adam” from a person and the triumph of the “Reborn man” living in the kingdom of Astrea. The “Moralizing Catechism” contains a refutation of government rumors about Masons as political enemies of Russia, describes in detail the ethical component of the private life of a true Freemason, including his attitude to family, servants, property. At the end of the article, the development of the tradition of “spiritual chivalry” in the works of Russian thinkers and writers of the 19th–20th centuries is outlined: from the Slavophiles to the culture of the Silver Age.
Research of the Relationship of Happiness with the Virtues and the “Seven Deadly Sins”
Authors:   Ural Federal University, Permiakova Margarita E. , Romanova-Pogrebnyak Olga N. Romanova-Pogrebnyak ,   Ural Federal University
Published: December 2022

The article presents the results of teaching English to children on the autism spectrum disorder (ASD). The initial stage comprised a survey on the assumptions of parents and professionals concerning the abilities and interests of children with ASD. The survey was completed by 16 parents bringing up such children and 10 professionals working in this area. Both parents and teachers noted that among other things children with ASD demonstrated good language learning abilities. The second and third stages of the study involved individual work with primary school students, which consisted in diagnostic testing of their English skills and offering subsequent English classes. One of the prospects for further research is to train children with ASD for inclusion in language learning.
Procrastination of Students Who Study Online Courses
Authors:   Ural Federal University, Lebedeva Julia V. , Maltsev Alexey V. ,   Ural Federal University, Sultanov Ilgar V. ,   Ural Federal University
Published: December 2022

Procrastination is one of the significant phenomenon that reduces success of educational activities at all stages of learning. Online learning fosters procrastination due to the fact that the teacher’s control of the situation decreases and there is more freedom in planning the academic load by the student himself. The aim of the work was to study the psychological characteristics of the students prone to procrastination. The sample consisted of 228 UrFU students who study online courses. Empirical methods: the “Scale of academic motivation” by Gordeeva, O. A. Sycheva and E. N. Osina (SHAM), “The scale of general procrastination” by K. H. Lay in adaptation by O. S. Vindeker and M. V. Ostanina, as well as the TIPI questionnaire by R. McCrae and P. Costa. Information about academic performance was obtained from the Point­rating system of the university. As a result, the level of procrastination of students was positively associated with amotivation and, interestingly, conscientiousness. Students with high and low levels of procrastination differ in the level of amotivation, and also have a different configuration of relationships between personal and motivational characteristics.
The role of the education system in the formation of the legal culture of youth: European experience
Authors:   Ural Federal University, Kerimov Alexandr A.
Published: December 2022

The article shows the experience of European countries in using the opportunities and resources of the education system in the formation of the legal culture of young people. The features of the participation of the education system and other participants in educational and socio-political relations in this process are revealed. The content of legal education of young people is marked out, its purpose is established, the role of the subjects of this process is characterized, the directions and mechanisms for achieving the goals are shown. The methodological basis of the article is the theoretical developments of Russian and foreign researchers. The article is based on general philosophical and socio-humanitarian methods of analysis.
The role of the German scientist Karl Fuchs in the development of the Kazan Internal Medicine School
Authors: Khalfina T. N. , Shamsutdinova N. G. , Bombina L. K. , Abdulganieva D. I.
Published: December 2022

The article is dedicated to Karl Fedorovich Fuchs, an outstanding doctor, scientist, and local historian, professor of the Department of Therapy, Pathology and Clinics, Dean of the Faculty of Medicine, Rector of the Imperial Kazan University. Being born in Germany, in the city of Herborn, he devoted his whole life to the benefit of Kazan and its inhabitants.

The article describes the research, teaching and medical activities of K. Fuchs, his contribution to the development of clinical teaching and the development of the internal medicine school in Kazan. We described the range of his scientific interests and the influence of research on the development of medicine in Kazan in the 19th century. Much attention is paid to the personality traits of K. F. Fuchs, an integral part of the doctor and teacher, which inspire students for further development.
Articles on the history of medicine in a scientific peer-reviewed journal. Editor's opinion
Authors: Rodionova Yu. V.
Published: December 2022

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Enhancement of the fruit quality and postharvest life expectancy of mango fruit (Mangifera indica L.) applying ecofriendly bio-coatings
Authors: FATIMA Farzana , BASIT Abdul , AHMAD Aqeel , SHAH Syed T. , SAJID Muhammad , AMAN Faiza , MOHAMED Heba I. , ELHAKEM Abeer
Published: December 2022

The higher losses of fruits and vegetables during post-harvest handling are a serious matter for any country whose economy is based on agriculture. The products of this plant are a significant source of horticultural produce storage used for the control of different post-harvest losses, which include diseases as well as microorganisms. Bio-coatings may be used as a better alternative to the synthetic chemicals. The impact of edible coating on the quality and storage life of mango (cv. ‘Anwar Rataul’) fruit was investigated by harvesting the fruits at a firm green stage of physiological maturity and coating them with corn oil, peanut oil, sunflower oil, soya bean oil, and animal fat. The uncoated and coated fruits were stored at 25 °C and the relative humidity (RH) was 75%. The fruits were analyzed for physicochemical quality attributes during storage at 0 (harvest time), 5, 10, 15, 20, and 25 days. The data showed that most of the parameters were affected significantly by the materials of coating and storage intervals (P ≤ 0.05). The fruits coated with animal fat had significantly superior fruit color, taste, aroma, firmness, total sugar content, and acidity of fruit juice, total soluble solids, and ascorbic acid content, as well as delayed ripening. Animal fat-coated fruits retained titratable acidity, ascorbic acid content (mg.100g-1) and fruit firmness (kg.cm-2) with minimal disease incidence, and weight loss (%), whereas uncoated fruits did not retain all quality attributes and deteriorated after 20 days of storage. In conclusion, mango fruits could be coated with animal fat and stored for up to 25 days without deterioration in quality.
Understanding the physiological and molecular mechanism of salinity stress tolerance in plants
Authors: ANWAR Ali , ZHANG Shu , HE Lilong , GAO Jianwei
Published: December 2022

Salinity is considered a global threat to agriculture and causes a significant reduction in crop yield. In particular, salinity stress promotes reactive oxygen species (ROS) accumulation and ionic imbalance in cells, leading to oxidative stress and even cell death. A large number of genes which are involved in defense, hormone, carbohydrate and metabolic pathways are down-regulated under salinity stress. Plants respond to salinity stress through a series of physiological and molecular mechanisms including antioxidant enzymes, hormones, defense related genes and signaling pathway activation. Plant defense systems modulate the overproduction of ROS through the activation of stress responsive-genes such as superoxide dismutase (SOD), peroxidase (POD), catalase (CAT) and glutamine synthetase (GS) and transcription factors such as MYBs, WRKY, and ERF. The salt overly sensitive (SOS) pathway is potentially involved in salt stress tolerance. SOS1, SOS3 and SOS2 are required for the oxidative stress tolerance by reducing the uptakes, and inter-cellular and intra-cellular distribution of Na+ and Cl−. This review discusses the discovery of stress-responsive genes and signaling pathways, and summarizes the research progress on the regulatory mechanisms of salinity stress tolerance in plants, which will help accelerate breeding programs for salinity stress tolerance.