bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhanced Electromagnetic Wave Absorption in W-Type Ba-Hexaferrites: Role of Composition and Grain Growth
Authors: Heo Jae-Hee , Kang Young-Min
Published: November 2024

W-type Ba-hexaferrite, BaZn2−xCoxFe16O27, was synthesized via both conventional solid-state (x = 0.4, 0.5, 0.6, 0.75, 1.0, 1.25, 1.5) and molten-salt methods (x = 0.75, 1.0, 1.25). The structure, electromagnetic (EM) properties, and EM wave absorption characteristics were examined across a frequency range of 0.1–18 GHz, focusing on the influence of varying x. As x increased from 0.4 to 0.75, the magnetic anisotropy field (Hani) decreased, reaching its minimum at x = 0.75, before rising again as x continued to increase up to 1.5. Hani was found to be proportional to the ferromagnetic resonance (FMR) frequency, allowing for the tuning of the EM wave absorption frequency range. W-type hexaferrite–epoxy composites (10 wt%) with x values between 0.6 and 1.5 exhibited outstanding wideband EM wave absorption, with a maximum absorption (RLmin < −50 dB) and a wide absorption bandwidth where RL < −10 dB extended beyond 10 GHz (Δfwb > 10 GHz). The x = 1.25 sample with a thickness of 2.37 mm achieved RLmin = −69 dB at 7.8 GHz, while the x = 1.0 sample with a thickness of 2.33 mm delivered Δfwb = 12.5 GHz (5.1–17.6 GHz). Samples synthesized via the molten-salt method showed larger plate-like grain growth compared to those produced by the solid-state method, with permeability spectra shifting to lower frequencies, consequently lowering the EM wave absorption band.
Study on the Influence of Physical Activity Intensity and Maturation on Sports Injuries in Children and Adolescents
Authors: Costa e Silva Lara , Silva Ana Lúcia , Teles Júlia , Fragoso Isabel
Published: November 2024

Intensive training combined with a growing body can predispose children to sports injuries. Our aim was to identify the importance of physical activity (PA) intensity and maturity as predictors of injury in youth. Information about injuries was collected using a questionnaire (LESADO), the PA intensity was assessed via accelerometry, and maturity was assessed using the Tanner–Whitehouse III bone age method and maturity offset. A total of 121 participants aged between 10 and 18 years were selected from four different schools. Regression analyses were used to determine the significant predictors of the injury profile. Only the injury type presented significant results. The time spent on moderate PA (χ2(2) = 6.701, p = 0.035) and bone age (χ2(2) = 7.196, p = 0.027) were the final predictors. The odds of having a strain or a fracture relative to a sprain increased 1.04 times for each minute of time spent on moderate PA. Likewise, the odds of having a strain or a fracture relative to a sprain decreased by 1.7 times per year of bone age. The PA intensity and bone age proved to be injury predictors in the growing athletes, with more predictive power in injury type. No meaningful associations were found for the injury occurrence, injury rate and body area injury location.
Advanced Distribution System Optimization: Utilizing Flexible Power Buses and Network Reconfiguration
Authors: Clavijo-Camacho Jesus , Ruiz-Rodríguez Francisco J. , Sánchez-Herrera Reyes , Alamo Alvaro C.
Published: November 2024

The increasing integration of distributed generation (DG) and the rise of microgrids have reshaped the operation of distribution systems, introducing both challenges and opportunities for optimization. This study presents a methodology that combines network reconfiguration with the integration of buses with flexible power in order to improve the efficiency and cost-effectiveness of distribution networks. Flexible buses, which aggregate multiple microgrids or controllable distributed resources, function as control points that can dynamically adjust active and reactive power within predefined limits. This capability allows for more precise management of power flows, enabling the system to respond to fluctuations in generation and demand. The proposed optimization framework aims to minimize the total operational costs, including power losses and the use of flexible power, while adhering to system constraints. The methodology is evaluated through case studies on two distribution systems: the Kumamoto and IEEE-33 systems. The results indicate a 43.9% reduction in power losses for the Kumamoto system and a 66.6% reduction for the IEEE-33 system, along with notable cost savings in both cases. These outcomes demonstrate the potential benefits of incorporating flexible power buses in modern radial distribution networks, showing their role in adapting to various operational scenarios and supporting the integration of distributed generation and microgrids.
The Inactivation of Microscopic Fungi in Bakery Products Using Hurdle Technology—A Case Study
Authors: Diowksz Anna , Kopeć Przemysław , Koziróg Anna
Published: November 2024

The issue of the microbiological spoilage of bakery products with an extended shelf life declared by the producer was the reason for searching for an effective solution. The aim of the investigation was to find the sources of infection, identify microorganisms causing product spoilage, and propose ways to eliminate the problem without the use of chemical preservatives in the product. It was found that the dominant contaminating microorganisms are yeasts of the genus Hyphopichia sp., Saccharomyces sp., and Candida spp., as well as molds—Aspergillus spp. and Penicillium spp. The microbiological quality of the production environment was assessed, and as a remedial action, a disinfection process was carried out. The influence of gas composition in MAP (modified atmosphere packaging) and the use of ethanol during packaging on the incidence of yeast or mold occurrence was checked. The effectiveness of using sourdough was also tested. The best results were achieved by using sourdough obtained with selected starter cultures and using a gas mixture for packaging in the proportion of 70% carbon dioxide and 30% nitrogen, without the addition of ethanol. These conditions ensured the expected shelf life of bakery products while maintaining their quality.
High-Energy Neutrino Flavor State Transition Probabilities
Authors: Harrison John , Anantua Richard
Published: November 2024

We analytically determine neutrino transitional probabilities and abundance ratios at various distances from the source of creation in several astrophysical contexts, including the Sun, supernovae and cosmic rays. In doing so, we determine the probability of a higher-order transition state from ντ→νλ, where νλ represents a more massive generation than Standard Model neutrinos. We first calculate an approximate cross-section for high-energy neutrinos which allows us to formulate comparisons for the oscillation distances of solar, supernova and higher-energy cosmic ray neutrinos. The flavor distributions of the resulting neutrino populations from each source detected on Earth are then compared via fractional density charts.
Seasonal and Diurnal Characteristics and Drivers of Urban Heat Island Based on Optimal Parameters-Based Geo-Detector Model in Xinjiang, China
Authors: Chen Han , Mamitimin Yusuyunjiang , Abulizi Abudukeyimu , Huang Meiling , Tao Tongtong , Ma Yunfei
Published: November 2024

In the context of sustainable urban development, elucidating urban heat island (UHI) dynamics in arid regions is crucial. By thoroughly examining the characteristics of UHI variations and potential driving factors, cities can implement effective strategies to reduce their impacts on the environment and public health. However, the driving factors of a UHI in arid regions remain unclear. This study analyzed seasonal and diurnal variations in a surface UHI (SUHI) and the potential driving factors using Pearson’s correlation analysis and an Optimal Parameters-Based Geographic Detector (OPGD) model in 22 cities in Xinjiang, northwest China. The findings reveal that the average annual surface urban heat island intensity (SUHII) values in Xinjiang’s cities were 1.37 ± 0.86 °C, with the SUHII being most pronounced in summer (2.44 °C), followed by winter (2.15 °C), spring (0.47 °C), and autumn (0.40 °C). Moreover, the annual mean SUHII was stronger at nighttime (1.90 °C) compared to during the daytime (0.84 °C), with variations observed across seasons. The seasonal disparity of SUHII in Xinjiang was more significant during the daytime (3.91 °C) compared to nighttime (0.39 °C), with daytime and nighttime SUHIIs decreasing from summer to winter. The study also highlights that the city size, elevation, vegetation cover, urban form, and socio-economic factors (GDP and population density) emerged as key drivers, with the GDP exerting the strongest influence on SUHIIs in cities across Xinjiang. To mitigate the UHI effects, measures like urban environment enhancement by improving surface conditions, blue–green space development, landscape optimization, and economic strategy adjustments are recommended.
The Response of Cloud Precipitation Efficiency to Warming in a Rainfall Corridor Simulated by WRF
Authors: Guo Qi , Chen Yixuan , Miao Xiongyi , Hao Yupei
Published: November 2024

Due to model errors caused by local variations in cloud precipitation processes, there are still significant uncertainties in current predictions and simulations of short-duration heavy rainfall. To tackle this problem, the effects of warming on cloud-precipitation efficiency was analyzed utilizing a weather research and forecasting (WRF) model. The analysis focused on a rainstorm corridor event that took place in July 2020. Rainstorm events from 4–6 July formed a narrow rain belt with precipitation exceeded 300 mm in the middle and lower reaches of the Yangtze River. Temperature sensitivity tests revealed that warming intensified the potential temperature gradient between north and south, leading to stronger upward motion on the front. It also strengthened the southwest wind, which resulted in more pronounced precipitation peaks. Warming led to a stronger accumulation and release of convective instability energy. Convective available potential energy (CAPE) and convective inhibition (CIN) both increased correspondingly with the temperature. The precipitation efficiency increased sequentially with 2 °C warming to 27.4%, 31.2%, and 33.1%. Warming can affect the cloud precipitation efficiency by both promoting and suppressing convective activity, which may be one of the reasons for the enhancement of extreme precipitation under global warming. The diagnostic relationship between upward moisture flux and lower atmospheric stability during precipitation evolution was also revealed.
The Influence of Relative Humidity and Pollution on the Meteorological Optical Range During Rainy and Dry Months in Mexico City
Authors: Miranda-Claudes Blanca Adilen , Montero-Martínez Guillermo
Published: November 2024

The Meteorological Optical Range (MOR) is a measurement of atmospheric visibility. Visibility impairment has been linked to increased aerosol levels in the air. This study conducted statistical analyses using meteorological, air pollutant concentration, and MOR data collected in Mexico City from August 2014 to December 2015 to determine the factors contributing to haze occurrence (periods when MOR < 10,000 m), defined using a light scatter sensor (PWS100). The outcomes revealed seasonal patterns in PM2.5 and relative humidity (RH) for haze occurrence along the year. PM2.5 levels during hazy periods in the dry season were higher compared to the wet season, aligning with periods of poor air quality (PM2.5 > 45 μg/m3). Pollutant-to-CO ratios suggested that secondary aerosols’ production, led by SO2 conversion to sulfate particles, mainly impacts haze occurrence during the dry season. Meanwhile, during the rainy season, the PWS100 registered haze events even with PM2.5 values close to 15 μg/m3 (considered good air quality). The broadened distribution of extinction efficiency during the wet period and its correlation with RH suggest that aerosol water vapor uptake significantly impacts visibility during this season. Therefore, attributing poor visibility strictly to poor air quality may not be appropriate for all times and locations.
A Reanalysis Precipitation Integration Method Utilizing the Generalized Three-Cornered Hat Approach and High-Resolution, Gauge-Based Datasets
Authors: Zhang Lilan , Chen Xiaohong , Huang Bensheng , Liu Jie , Chen Daoyi , Chen Liangxiong , Lai Rouyi , Zheng Yanhui
Published: November 2024

The development of high-precision, long-term, hourly-scale precipitation data is essential for understanding extreme precipitation events. Reanalysis systems are particularly promising for this type of research due to their long-term observations and wide spatial coverage. This study aims to construct a more robust precipitation dataset by integrating three widely-used reanalysis precipitation estimates: Modern-Era Retrospective Analysis for Research and Applications Version 2 (MERRA2), Climate Forecast System Reanalysis (CFSR), and European Centre for Medium-Range Weather Forecasts Reanalysis v5 (ERA5). A novel integration method based on the generalized three-cornered hat (TCH) approach is employed to quantify uncertainties in these products. To enhance accuracy, the high-density daily precipitation data from the Asian Precipitation-Highly-Resolved Observation Data Integration Towards Evaluation (APHRODITE) dataset is used for correction. Results show that the TCH method effectively identifies seasonal and spatial uncertainties across the products. The TCH-weighted product (TW), calculated using signal-to-noise ratio weighting, outperforms the original reanalysis datasets across various watersheds and seasons. After correction with APHRODITE data, the enhanced integrated product (ATW) significantly improves accuracy, making it more suitable for extreme precipitation event analysis. Quantile mapping was applied to assess the ability of TW and ATW to represent extreme precipitation. Both products showed improved accuracy in regional average precipitation, with ATW demonstrating superior improvement. This integration method provides a robust approach for refining reanalysis precipitation datasets, contributing to more reliable hydrological and climate studies.
Explainable Pre-Trained Language Models for Sentiment Analysis in Low-Resourced Languages
Authors: Mabokela Koena Ronny , Primus Mpho , Celik Turgay
Published: November 2024

Sentiment analysis is a crucial tool for measuring public opinion and understanding human communication across digital social media platforms. However, due to linguistic complexities and limited data or computational resources, it is under-represented in many African languages. While state-of-the-art Afrocentric pre-trained language models (PLMs) have been developed for various natural language processing (NLP) tasks, their applications in eXplainable Artificial Intelligence (XAI) remain largely unexplored. In this study, we propose a novel approach that combines Afrocentric PLMs with XAI techniques for sentiment analysis. We demonstrate the effectiveness of incorporating attention mechanisms and visualization techniques in improving the transparency, trustworthiness, and decision-making capabilities of transformer-based models when making sentiment predictions. To validate our approach, we employ the SAfriSenti corpus, a multilingual sentiment dataset for South African under-resourced languages, and perform a series of sentiment analysis experiments. These experiments enable comprehensive evaluations, comparing the performance of Afrocentric models against mainstream PLMs. Our results show that the Afro-XLMR model outperforms all other models, achieving an average F1-score of 71.04% across five tested languages, and the lowest error rate among the evaluated models. Additionally, we enhance the interpretability and explainability of the Afro-XLMR model using Local Interpretable Model-Agnostic Explanations (LIME) and Shapley Additive Explanations (SHAP). These XAI techniques ensure that sentiment predictions are not only accurate and interpretable but also understandable, fostering trust and reliability in AI-driven NLP technologies, particularly in the context of African languages.
Usable Privacy and Security in Mobile Applications: Perception of Mobile End Users in Saudi Arabia
Authors: Saeed Saqib
Published: November 2024

Privacy and security is very critical for mobile users and in-depth research into the area highlights a need for more scientific literature on the perception and challenges of end users to better align the design of privacy and security controls with user expectations. In this paper, we have explored the perceptions of the usability of privacy and security settings in mobile applications from mobile users in Saudi Arabia. The findings highlight that gender, age, and education level of users do not have any positive correlation with the privacy and security usability perceptions of mobile users. On the other hand, user concerns about privacy and security and the trustworthiness levels of end users regarding mobile phone privacy and security have a positive impact on end users’ perception of privacy and security usability. Furthermore, privacy usability perception has a positive impact on users’ feelings about their control over the privacy and security of their mobile phones. Based on the results of this empirical study, we propose that user-centric design of privacy and security controls, transparent data handling policies, periodic data management status preview and validation by end users, user education guidelines, strict governmental policies, and automated security settings recommendations can enhance the usability of the privacy and security of mobile phone applications. Our study did not take the geographical location of respondents into account, nor were the respondents balanced based on age and gender. In future work, these weaknesses need to be taken into account, and more qualitative studies can help to extract design guidelines for usable and secure mobile applications.
Tissue-Specific Effects of Aging on Repeat-Mediated Mutation Hotspots In Vivo
Authors: D’Amico Alexandra M. , Li Tonia T. , Vasquez Karen M.
Published: November 2024

Aging constitutes complex and dynamic alterations in molecular and physiological processes and is associated with numerous disorders, in part due to increased genetic instability. The aging population is projected to double by 2050, underscoring the urgent need to better understand the relationships between aging and age-related disorders. Repetitive DNA elements are intrinsic sources of genetic instability and have been found to co-localize with mutation hotspots in human cancer genomes. In this study, we explored the relationship between aging and DNA repeat-mediated genetic instability in vivo using an H-DNA-forming mirror-repeat sequence from the cancer-associated human c-MYC gene. Utilizing a unique mutation-reporter mouse model, we observed tissue-specific effects of aging on H-DNA-induced genetic instability, with mutation frequencies increasing in spleen tissues and remaining unchanged in testis tissues. Analysis of the mutation spectra revealed large deletion mutations as the primary contributor to increasing H-DNA-induced mutations, supported by increased cleavage activity of H-DNA structures in aged spleen tissues. Our findings demonstrate that aging has distinct tissue-specific effects on repeat-mediated, cancer-associated mutations, providing insights into the complex relationship between aging and cancer.
Modulation of the Gut–Lung Axis by Water Kefir and Kefiran and Their Impact on Toll-like Receptor 3-Mediated Respiratory Immunity
Authors: Dentice Maidana Stefania , Argañaraz Aybar Julio Nicolás , Albarracin Leonardo , Imamura Yoshiya , Arellano-Arriagada Luciano , Namai Fu , Suda Yoshihito , Nishiyama Keita , Villena Julio , Kitazawa Haruki
Published: November 2024

The beneficial effect of milk kefir on respiratory heath has been previously demonstrated; however, water kefir and kefiran in the context of respiratory viral infections have not been investigated. Water kefir and kefiran could be alternatives to milk kefir for their application in persons with lactose intolerance or milk allergy and could be incorporated into vegan diets. Using mice models, this work demonstrated that the oral administration of water kefir or kefiran can modulate the respiratory Toll-like receptor (TLR3)-mediated innate antiviral immunity and improve the resistance to respiratory syncytial virus (RSV) infection. The treatment of mice with water kefir or kefiran for 6 days improved the production of interferons (IFN-β and IFN-γ) and antiviral factors (Mx2, OAS1, RNAseL, and IFITM3) in the respiratory tract after the activation of the TLR3 signaling pathway, differentially modulated the balance of pro- and anti-inflammatory cytokines, reduced RSV replication, and diminished lung tissue damage. Maintaining a proper balance between anti-inflammatory and pro-inflammatory mediators is vital for ensuring an effective and safe antiviral immune response, and the results of this work show that water kefir and kefiran would help to maintain that balance promoting a controlled inflammatory response that defends against infection while minimizing tissue damage.
Tumor-Colonizing E. coli Expressing Both Collagenase and Hyaluronidase Enhances Therapeutic Efficacy of Gemcitabine in Pancreatic Cancer Models
Authors: Avsharian Lara C. , Loganathan Suvithanandhini , Ebelt Nancy D. , Shalamzari Azadeh F. , Rodarte Muñoz Itzel , Manuel Edwin R.
Published: November 2024

Desmoplasia is a hallmark feature of pancreatic ductal adenocarcinoma (PDAC) that contributes significantly to treatment resistance. Approaches to enhance drug delivery into fibrotic PDAC tumors continue to be an important unmet need. In this study, we have engineered a tumor-colonizing E. coli-based agent that expresses both collagenase and hyaluronidase as a strategy to reduce desmoplasia and enhance the intratumoral perfusion of anticancer agents. Overall, we observed that the tandem expression of both these enzymes by tumor-colonizing E. coli resulted in the reduced presence of intratumoral collagen and hyaluronan, which likely contributed to the enhanced chemotherapeutic efficacy observed when used in combination. These results highlight the importance of combination treatments involving the depletion of desmoplastic components in PDAC before or during treatment.
The Impact of Probiotics on Clinical Symptoms and Peripheral Cytokines Levels in Parkinson’s Disease: Preliminary In Vivo Data
Authors: Magistrelli Luca , Contaldi Elena , Visciglia Annalisa , Deusebio Giovanni , Pane Marco , Amoruso Angela
Published: November 2024

Introduction. Previous studies have shown that probiotics have positive effects on both motor and non-motor symptoms in Parkinson’s disease (PD). Additionally, in preclinical settings, probiotics have demonstrated the ability to counteract neuronal loss and alpha-synuclein aggregation, important pathological hallmarks of PD. Notably, preliminary in vitro studies have revealed the immunomodulatory properties of probiotics. This study aims to evaluate the impact of probiotics on symptoms and peripheral cytokines levels in PD patients compared to placebo. Methods. Patients were enrolled and blindly randomized to receive either active probiotics (comprising Bifidobacterium animalis subsp. lactis BS01 LMG P-21384, Bifidobacterium longum BL03 DSM 16603, Bifidobacterium adolescentis BA02 DSM 18351, Fructo-oligosaccharides and Maltodextrin-Group A) or placebo (Maltodextrin-Group B). Clinical evaluations and plasma levels cytokines (TNF-α, IFN-γ, IL-6, and TGF-β) were also assessed at enrollment and after 12 weeks. Anti-parkinsonian therapy remained stable throughout the study. Results. Forty PD patients were recruited. After 12 weeks, Group A showed significant improvement in motor symptoms (UPDRS III: 13.89 ± 4.08 vs. 12.74 ± 4.57, p = 0.028) and non-motor symptoms (NMSS: 34.32 ± 21.41 vs. 30.11 ± 19.89, p = 0.041), with notable improvement in the gastrointestinal sub-item (3.79 ± 4.14 vs. 1.89 ± 2.54, p = 0.021). A reduction of IFN-γ levels was observed in both groups, but group A also showed a significant decrease in IL-6 and a slight increase in the anti-inflammatory cytokine TGF-β. Conclusions. Our data suggest that probiotics may modulate peripheral cytokines levels and improve clinical symptoms in PD patients. Probiotics may, therefore, represent a valuable adjunctive therapy to conventional anti-parkinsonian drugs.
Effects of Sarcosine (N-methylglycine) on NMDA (N-methyl-D-aspartate) Receptor Hypofunction Induced by MK801: In Vivo Calcium Imaging in the CA1 Region of the Dorsal Hippocampus
Authors: Hsiao Yi-Tse , Chang Ching-Yuan , Lee Ting-Yen , Liao Wan-Ting , Lai Wen-Sung , Chang Fang-Chia
Published: November 2024

Background: Hypofunction of the glutamate system in the brain is one of the pathophysiological hypotheses for schizophrenia. Accumulating animal and clinical studies show that sarcosine (N-methylglycine), a glycine transporter-1 inhibitor, is effective in ameliorating the negative and cognitive symptoms of schizophrenia. The aims of the present study were to observe the effects of sarcosine on neuronal activity in the dorsal CA1 (dCA1) hippocampal neurons within an NMDA receptor hypofunction model induced by MK801. Methods: We applied in vivo calcium imaging to observe the dynamics of fluorescence from the dCA1 hippocampal neurons when the mice were exploring in an open field. Using this tool, we directly measured and compared neuronal properties between sarcosine-treated and untreated mice. At the same time, the physiological function of the neurons was also quantified by measuring their place fields. Results: Our data demonstrated that MK-801 (0.2 mg/kg) diminished the fluorescence intensity of dCA1 neurons that had been genetically modified with a calcium indicator. MK-801 also significantly increased the correlation coefficient between the fluorescence dynamics of pairs of cells, a feature that may be linked to the symptom of disorganization in human patients with schizophrenia. The spatial correlations of place fields in the mice were impaired by MK-801 as well. Injected sarcosine (500 mg or 1000 mg/kg) significantly alleviated the abovementioned abnormalities. Conclusions: Our data provide evidence to support the use of sarcosine to alleviate symptoms of schizophrenia, especially hippocampus-related functions.
The Influence of Music Reading on Spatial Working Memory and Self-Assessment Accuracy
Authors: Cara Michel A.
Published: November 2024

Background/Objectives: Previous research has suggested that Western musicians, who generally demonstrate proficiency in reading musical scores, exhibit superior performance in visuospatial working memory tasks compared to non-musicians. Evidence indicates brain activation in regions such as the left inferior parietal lobe and the right posterior fusiform gyrus during music reading, which are associated with visuospatial processing. This study aimed to explore how musical training influences spatial working memory and to examine the relationship between self-assessment accuracy and cognitive performance. Methods: A visuospatial working memory test, the Corsi block-tapping test (CBT), was administered to 70 participants, including 35 musicians with experience in music reading and 35 non-musicians. CBT performances were compared between groups, controlling for sex and age differences using analysis of covariance. Participants were also asked to self-assess their visuospatial capabilities. Results: Musicians performed significantly better than non-musicians in the CBT and demonstrated greater metacognitive accuracy in evaluating their visuospatial memory capacities. A total of 46.34% of musicians who claimed good performance on the CBT did in fact perform well, in comparison with 14.63% of non-musicians. Sex influenced the outcomes of spatial working memory, while age did not significantly affect performance. Conclusions: This self-awareness of visuospatial capabilities reflects a form of metacompetence, encompassing reflective thinking and the ability to assess one’s cognitive skills. Furthermore, while differences in spatial working memory between musicians and non-musicians appear to be related to executive functions associated with general music practice, further investigation is needed to explore other potential influences beyond musical experience.
Neuroticism Overestimated? Neuroticism Versus Hypertonia, Pain and Rehabilitation Outcomes in Post-Spinal Cord Injury Patients Rehabilitated Conventionally and with Robotic-Assisted Gait Training
Authors: Widuch-Spodyniuk Alicja , Tarnacka Beata , Korczyński Bogumił , Borkowska Aleksandra
Published: November 2024

Background: The aim of the present study was to analyse the association between neuroticism (one of the Big Five personality traits) and the most common secondary sensorimotor complications occurring in patients after spinal cord injury (SCI), i.e., muscle spasticity (hypertonia) and pain, and to investigate the associations between neuroticism and the effects of conventional rehabilitation (dynamic parapodium) and those using robotic-assisted gait training (RAGT) in this group of patients. In addition, the association of neuroticism with self-efficacy, personal beliefs about pain control, and adopted coping strategies among SCI patients was analysed. These data can be used as a reference for designing effective forms of therapy and support dedicated to this group of patients. Methods and procedures: Quantitative analysis included 110 patients after SCI. The participants were divided by simple randomisation into a rehabilitation group with RAGT and a rehabilitation group with dynamic parapodium therapy (DPT). The following survey instruments were used for data collection: Revised NEO Personality Inventory (NEO-PI-R); Ashworth Scale; the Spinal Cord Independence Measure III (SCIM III); the Walking Index for Spinal Cord Injury II (WISCI-II); the American Spinal Injury Association Impairment Scale (AIS); the Pain Coping Strategies Questionnaire—CSQ; and the Beliefs about Pain Control Questionnaire—BPCQ. Outcomes and results: analyses showed a positive association between neuroticism and spastic tension (rho = 0.39; p < 0.001). Conclusions and implications: the study showed that a high level of neuroticism correlates with a higher level of spasticity, but no such correlation was observed for pain. Additionally, the study did not show a significant correlation between neuroticism and rehabilitation outcome depending on the rehabilitation modality (RAGT vs. DPT). The results underline the importance of carrying out a psychological diagnosis of patients to provide therapeutic support in the rehabilitation process.
Experimental Study on Fabrication of Environment-Friendly Concrete by Solidifying Aeolian Sand and Natural Gravel with Fly Ash-Based Geopolymer
Authors: Guan Shi-Yu , Tang Bin-Peng , Zhang Xie-Dong , Liu Ying-Qi , Yang Zheng-Xun
Published: November 2024

To tackle the shortage of river sand resources and excessive carbon emissions in building materials, environment-friendly concrete can be fabricated by solidifying aeolian sand and natural gravel with a fly ash-based geopolymer. Aeolian sand and natural gravel are accessible building materials, but their engineering applications are largely limited by their poor properties such as high mud content, large specific surface area, and discontinuous particle size distribution. To enhance the application of this environment-friendly concrete, in this paper, 48 sets of specimens with different geopolymer dosages, curing temperatures, and curing times are studied experimentally, and quite well-strengthened geopolymer aeolian sand mortar (GAM), geopolymer aeolian sand concrete (GAC), and an appropriate dosage of the geopolymer are finally obtained. The experimental results and the failure section of the mortar specimen indicate that the fly ash geopolymer can solidify the aeolian sand and ensure the integrity and compactness of the specimen. The 28-day compressive and flexural strength of the geopolymer standard sand mortar (GSM) reached 40.5 MPa and 4.3 MPa, respectively, at a curing temperature of 60 °C when the amount of alkali activator was improved to 100%, and the 28-day compressive and flexural strength of GAM reached 33.7 MPa and 4.2 MPa, respectively, when the amount of geopolymer material was 0.75 times that of aeolian sand. A lower compressive strength of GAC was obtained following the addition of aeolian sand. The experiment results can provide a reference for aeolian sand usage and have a certain social value in environmental protection.
Georadar Survey and Simulation for Subsurface Investigation at Historical Mosque of Sorghatmesh, Cairo, Egypt
Authors: Elkarmoty Mohamed , Allam Hussien E. , Helal Khalid , Ahmed Fathy , Bonduà Stefano , Mourad Sherif A.
Published: November 2024

Sorghatmesh mosque is a historical structure that was constructed in Cairo, Egypt, by Prince Saif El-Din Sorghatmesh in 1356. A dual-frequency ground-penetrating radar (GPR) with 250–700 MHz was used to investigate the subsurface of the Sorghatmesh mosque for restoration purposes. A total of 37 lines were surveyed on the ground floor of the mosque. The subsurface utilities were detected, and the status of the concrete base and the medium of the ground floor were assessed. A set of subsurface anomalies were detected and interpreted within the ground floor area of the mosque. In order to validate the interpretation, a trial pit was drilled on the ground floor, allowing for the visual inspection of the subsurface, and a Georadar numerical simulation was carried out to study the responses of the subsurface materials and conditions. For a better comprehension of the results, the ground floor area was categorized into five zones where the GPR interpretations between survey lines are almost similar. This work not only demonstrates the effectiveness of GPR as a non-invasive investigation tool but also highlights the potential of integrating advanced technologies into cultural heritage preservation by offering refined methodologies and insights for future research and restoration efforts.
Multicellular Cancer-Stroma Spheres (CSS) for In Vitro Assessment of CAR-T Cell-Associated Toxicity
Authors: Rakhmatullina Aigul R. , Zolotykh Mariya A. , Filina Yuliya V. , Valiullina Aigul Kh. , Zmievskaya Ekaterina A. , Gafurbaeva Dina U. , Sagdeeva Aisylu R. , Bulatov Emil R. , Rizvanov Albert A. , Miftakhova Regina R.
Published: November 2024

CAR-T therapy has revolutionized the field of oncology, offering a promising treatment option for cancer patients. However, the significant morbidity associated with therapy-related toxicity presents a major challenge to its widespread use. Despite extensive research into the underlying mechanisms of CAR-T therapy-related toxicity, there are still many unknowns. Furthermore, the lack of adequate in vitro models for assessing immunotoxicity and neurotoxicity further complicates the development of safer cellular therapies. Previously in our laboratory, we developed cancer-stroma spheres (CSS) composed of prostate adenocarcinoma PC3 cells and mesenchymal stem cells (MSC). Herein we present evidence that multicellular CSS could serve as a valuable in vitro model for toxicity studies related to CAR-T therapy. CSS containing CD19-overexpressing PC3M cells exhibited increased secretion of CAR-T cell toxicity-associated IL-8, MCP-1, and IP-10 in the presence of anti-CD19 CAR-T cells, compared to spheres derived from single cell types.
The Two Sides of Indoleamine 2,3-Dioxygenase 2 (IDO2)
Authors: Suvieri Chiara , Belladonna Maria Laura , Volpi Claudia
Published: November 2024

Indoleamine 2,3-dioxygenase 1 (IDO1) and IDO2 originated from gene duplication before vertebrate divergence. While IDO1 has a well-defined role in immune regulation, the biological role of IDO2 remains unclear. Discovered in 2007, IDO2 is located near the IDO1 gene. Because of their high sequence similarity, IDO2 was initially thought to be a tryptophan (Trp)-degrading enzyme like IDO1. Differently from what expected, IDO2 displays extremely low catalytic activity toward Trp. Nevertheless, many studies, often contradictory, have tried to demonstrate that IDO2 modulates immune responses by catabolizing Trp into kynurenine, an unconvincing hypothesis linked to an incomplete understanding of IDO2’s activity. In this study, we review IDO2’s functional role beyond Trp metabolism. IDO2’s evolutionary persistence across species, despite being almost inactive as an enzyme, suggests it has some relevant biological importance. IDO2 expression in human normal cells is poor, but significant in various cancers, with two prevalent SNPs. Overall, the comparison of IDO2 to IDO1 as a Trp-degrading enzyme may have led to misunderstandings about IDO2’s true physiological and pathological roles. New insights suggest that IDO2 might function more as a signaling molecule, particularly in cancer contexts, and further studies could reveal its potential as a target for cancer therapy.
Inflammation: The Cause of All Diseases
Authors: Chavda Vivek P. , Feehan Jack , Apostolopoulos Vasso
Published: November 2024

Inflammation is an essential biological process that serves as the body’s first line of defence against harmful stimuli, including pathogens, damaged cells, and irritants [...]
Thrombospondin 1 Mediates Autophagy Upon Inhibition of the Rho-Associated Protein Kinase Inhibitor
Authors: Catral Kirk Patrick Carreon , Tse Choi-Yee , Yang Wei-Ying , Ling Choi-Ying , Kwok Oi-Lam , Choy Kit-Ying , Lu Da-Qian , Bian Jing-Fang , Lam Thomas Chuen , Tse Dennis Yan-Yin , Shan Samantha Sze-Wan
Published: November 2024

Age-related macular degeneration (AMD) is a degenerative eye disease leading to central vision loss and is characterized by dysregulated autophagy of the retinal pigment epithelium (RPE) layer. Recent studies have suggested that rho-associated protein kinase (ROCK) inhibitors may enhance autophagy in neurodegenerative diseases and promote the survival of RPE cells. This study investigated the effect of ROCK inhibitors on autophagy gene expression and autophagic vacuole formation in a human RPE (ARPE-19) cell line. The highly selective and potent ROCK inhibitor Y-39983 enhanced the expression of autophagy genes in ARPE-19 cells and increased autophagic vacuole formation. A proteomic analysis using mass spectrometry was performed to further characterize the effects of ROCK inhibition at the protein level. Y-39983 downregulated thrombospondin-1 (THBS1), and suppression of THBS1 in ARPE-19 cells resulted in an increase in autophagic vacuole formation. Our data showed that ROCK inhibitor-induced autophagy was mediated by THBS1 downregulation. We identified ROCK and THBS1 as potential novel therapeutic targets in AMD.
Data-Driven Gas Holdup Correlation in Bubble Column Reactors Considering Alcohol Concentration and Carbon Number
Authors: Helchi Salar , Emamshoushtari Mir Mehrshad , Pajoum Shariati Farshid , Bonakdarpour Babak , Haddadi Bahram
Published: November 2024

Due to the complex relationship between various parameters affecting gas holdup in bubble column reactors, a unique correlation for gas holdup does not exist. The available correlations proposed in the literature for gas holdup prediction in aqueous alcohol solutions in bubble columns fail to predict gas holdup over a wide range of conditions. Therefore, based on around 1000 data points from the previous studies, an empirical correlation and a trained model were derived using the dimensionless numbers Reynolds, Froude, Eötvös to Morton ratio, and alcohol carbon number. The predictions were compared to experiments with different water–alcohol mediums at various concentrations to validate the correlation and trained model, and a good agreement was observed. However, the ML model was predicting more accurately, and it was indicated that the Reynolds number had the most significant impact on gas holdup, followed by the Eötvös to Morton ratio.
The Influence of Homogenous Magnetic Field Intensity on Surface Properties of Ni Thin Films Deposited from Citrate Baths and Their Role in Hydrogen Production
Authors: Elsharkawy Safya , Kutyła Dawid , Żabiński Piotr
Published: November 2024

Magnetic fields influence the deposition process and its current efficiency. They have a remarkable influence on thin films’ surface characteristics and catalytic properties. Here, we study the correlation between the magnetic flux density and the current efficiency of the deposition process in the presence of a magnetic field with different intensities in different directions: the directions parallel and perpendicular to the electrode surface. We also show how the magnetic field direction impacts the surface roughness. Furthermore, we also analyze the impact of these synthesized films on the hydrogen evolution reaction (HER) when using them as electrocatalysts and how the application of a magnetic field in two dissimilar orientations influences the surface roughness and wettability. The synthesized Ni films are characterized using a scanning electron microscope (SEM), X-ray diffraction (XRD), and atomic force microscopy (AFM).
Study on Mechanism of Microstructure Refinement by Ultrasonic Cavitation Effect
Authors: Li Chang , Li Shuchao , Liu Jiabo , Sun Yichang , Wang Yuhao , Kong Fanhong
Published: November 2024

During the solidification process of the alloy, the temperature lies in the range between the solid-phase line and the liquidus. Dendrite growth exhibits high sensitivity to even slight fluctuations in temperature, thereby significantly influencing the tip growth rate. The increase in temperature can result in a reduction in the rate of tip growth, whereas a decrease in temperature can lead to an augmentation of the tip growth rate. In cases where there is a significant rise in temperature, dendrites may undergo fracture and subsequent remelting. Within the phenomenon of ultrasonic cavitation, the release of internal energy caused by the rupture of cavitation bubbles induces a substantial elevation in temperature, thereby causing both dendrite remelting and fracture phenomena. This serves as the main mechanism behind microstructure refinement induced by ultrasonic cavitation. Although dendrite remelting and fracture exert significant influences on the solidification process of alloys, most studies primarily focus on microscopic characterization experiments, which fail to unveil the transient evolution law governing dendrite remelting and fracture processes. Numerical simulation offers an effective approach to address this gap. The existing numerical models primarily focus on predicting the dendrite growth process, while research on remelting and fracture phenomena remains relatively limited. Therefore, a dendrite remelting model was established by incorporating the phase field method (PFM) and finite element difference method (FDM) into the temperature-induced modeling, enabling a comprehensive investigation of the entire process evolution encompassing dendrite growth and subsequent remelting.
Correction: Chen et al. High-Sensitivity and -Stability Thin-Film Heat Flux Sensor Based on Transverse Thermoelectric Effect. Coatings 2023, 13, 1610
Authors: Chen Hao , Wang Yong , Yi Zao , Dai Bo , Tang Bin , Xu Xibin , Yi Yougen
Published: November 2024

In the original publication [...]
Optical Properties of Yttrium Ferrite Films Prepared by Pulse Laser Deposition
Authors: Sobola Dinara , Fawaeer Saleh H. , Kočková Pavla , Schubert Richard , Dallaev Rashid , Trčka Tomáš
Published: November 2024

This study investigates the optical properties of yttrium ferrite thin films fabricated via pulse laser deposition. Yttrium orthoferrite, a ferrimagnetic material known for its potential applications in spintronics and photonics, was deposited on single-crystal substrates under controlled conditions to analyze its optical characteristics. The influence of deposition time on the film quality and optical properties was examined. Atomic force microscopy in contact mode revealed surface roughness variations up to 35 nm, indicating the films’ ability to cover substrate defects. Reflectance measurements determined the optical band gap, which decreased from 3.17 eV for thinner films (44 nm) to 2.91 eV for thicker films (93 nm). Forbidden electronic transitions were also observed, attributed to heteroepitaxial growth and phonon interactions. These results demonstrate the effect of film thickness on morphology and optical properties, making YFeO3 films promising for a range of optoelectronic applications.
Embedment of Molybdenum Disulfide in Electrospun Fibers as an Integrated Cathode for Lithium-Ion Batteries
Authors: Pan Jiaqi , Liu Zhen , Zhang Baoyan , Qi Meili , Feng Yao
Published: November 2024

As an important component of LIBs, the electrode material plays a crucial role in determining the lithium (Li) storage performance in LIBs. In this study, MoS2 nano-flowers were synthesized using a one-pot hydrothermal method. The resulting MoS2 nano-flower, along with PAN, were used as raw materials for electrospinning. After annealing treatment, MoS2/(carbon nanofibers) CNFs nano-composites coated with carbon fibers were formed. The CNFs coating exhibited electrical conductivity and enhanced structural stability of the MoS2 due to the stabilizing effect of the carbon fibers. Additionally, electrochemical tests, including CV and GCD, indicated that the optimal capacity and cycling stability were achieved when the MoS2 content was 10%. The results indicated that the charge/discharge capacity of MoS2/CNFs-10% at a current density of 100 mA/g was ~650 mAh/g. After the cycling current returned to 100 mA/g, the current recovery was ~600 mAh/g, thereby indicating outstanding cycling stability. Accordingly, our fabrication technique and new insight could both widen design strategy of multicomponent composite electrode materials and promote the practical applications of the latest emerging transition metal sulfides in next-generation high-performance lithium-ion batteries.
Aloe Vera as a Printed Coating to Mitigate the Wear of Textiles
Authors: Karypidis Michail , Stalika Amalia , Zarkogianni Maria , Korlos Apostolos , Andriotis Eleftherios G.
Published: November 2024

Aloe vera is well known for its biological properties as a bioflavonoid anti-inflammatory and antibacterial agent. It has been used frequently in the food sector as a food coating due to its hygroscopic properties and as an ingredient in the lucrative cosmetic industry. Studies have also included aloe vera as an eco-friendly green solution based on these properties. The current research focuses on the use of aloe vera gel in printing pastes as an alternative sustainable solution to synthetic thickeners, evaluating its wet performance and ease of fabric stitching, and has been inspired by studies that similarly used this substance and measured its effect on the fabric’s coefficient of friction and antimicrobial action. In the current study, printing pastes with natural colourants, such as saffron, curcumin, and annatto, and aloe vera gel thickener derived from natural leaves from Crete increased the fabric’s mechanical resistance to abrasion compared to the untreated pastes. The measured performance did not differ substantially from prints with traditional synthetic pastes, hence tolerating the substitution with the non-contaminant variant. The enhanced resistance to abrasion and wear extends the fabric’s serviceable life and resulting garments, decreasing the need for high industry processing volumes and, as a result, reducing pollution. The resistance to wear was evaluated using the dominant method in textile testing of the Martindale apparatus, which measured the cycles to failure, weight loss, and general appearance deterioration using the official photographic standards.