bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Clinical Manifestation and Mortality-Related Risk Factors Between Elderly and Middle-Aged COVID-19 Patients
Authors: Akrami Majid , Hosamirudsari Hadiseh , Faraji Neda , Majd Masoomeh Nataj
Published: April 2024

Given that the risk factors associated with mortality and morbidity of Coronavirus Disease (COVID-19) vary among age groups, this study aimed to describe the differences in clinical characteristics and mortality-related risk factors between elderly and middle-aged COVID-19 patients. A total of 1061 patients were included in this retrospective cohort study. Patients’ radiology reports and laboratory data were extracted from the available data on the Hospital Information System (HIS), and clinical findings were added in special forms. We followed up cases until death or discharge to evaluate patients’ outcomes. Chronic obstructive pulmonary disease (COPD) (95% CI, HR 2.73 (0.97-6.62)), need for antibiotics (95% CI, HR 2.26 (1.20-4.26)), and diabetes (95% CI, HR 1.77 (0.97-3.24)) were associated with a higher risk of mortality among middle-aged COVID-19 patients; while, age (95% CI, HR 1.04 (1.01-1.06)) was associated with increased mortality rate in elderly patients. We found that the need for antibiotics was associated with a worse outcome of COVID-19. Additionally, we described the differences between elderly and middle-aged COVID-19 patients regarding their comorbidities, laboratory findings, and clinical manifestation.
Evaluation of Effectiveness of Combined Intra-Articular Injection of Ozone and High Molecular Weight Hyaluronic Acid in Patients With Knee Osteoarthritis
Authors: Shahinpour Shervin , Amirsabotki Mohsen , Nazemian Yazdi Nader Ali
Published: April 2024

Osteoarthritis is one of the major causes of disability and a source of social cost in the elderly. Its prevalence is increasing due to ageing and increasing obese population. The knee is one of the most common joints to be affected by osteoarthritis and it can lead to serious effects on one’s mobility, quality of life and livelihood. One of non-surgical treatments is intra-articular injection. Injection of both ozone and hyaluronic acid into knee joint are common methods for treatment of knee osteoarthritis. The aim of this study was to evaluate reduction of pain and improvement of function in patients who received combination of intra-articular injection of high molecular weight hyaluronic acid and ozone. In this retrospective case series study data of patients with knee osteoarthritis who underwent intra-articular injection of high molecular weight hyaluronic acid with ozone were evaluated. Participants had fulfilled Western Ontario and McMaster Universities Arthritis Index (WOMAC) short form questionnaire before, three days, one month and six months after the intra-articular injection. Pain reduction and function improvement factors were assessed according to the WOMAC short form questionnaire. A total of 65 patients were evaluated in this study. There was significant decrease in the total score of WOMAC SF (stiffness and function) in all three follow-ups (P<0.001). Also, patients who had more severe pain before the injection benefited more from the intra-articular injection. Our study showed that the effectiveness of intra-articular injection of high molecular weight hyaluronic acid with ozone does not depend on the age, sex and BMI of patients. Injection of high molecular weight hyaluronic acid and ozone into the joint cause to significant improvement in patient’s knee pain and function. It is recommended that the combination of high molecular weight hyaluronic acid and ozone be considered as an effective treatment in the process of these patients.
Nasopharyngeal carcinoma in children: a challenging disease in a middle-income country, Tunisia
Authors: Zarraa Semia , Jebali Souheil , Jdira Mariem Ben , Noubbigh GHaeit El Fida , Mousli A. , Yahyaoui Safia , Gritli Said , Nasr Chiraz
Published: April 2024

Background: This study aimed to assess the epidemiological, clinical, and therapeutic aspects and prognosis of juvenile nasopharyngeal carcinoma in Tunis country.
Materials and Methods: This study included 68 patients, younger than 18 years of age. All the patients had a clinical and para-clinical tumoral assessment. The study of survival and prognostic factors was done after a descriptive analysis. These prognostic factors were studied through uni and multivariate analysis.
Results: The median age was 14.7 years and the sex ratio was 2 male to 1 female. The average time to first consultation was 4 months. Rhinological signs were the most frequent symptom for consultation (n= 41). The T3-T4 tumors accounted for 78% of patients and there was a lymph node invasion stage N2-N3 in 63% of cases. Non-metastatic patients had radiotherapy associated with chemotherapy in 97% of cases. Metastatic patients received hypofractionated radiotherapy on bone metastasis, and first-line chemotherapy followed by radiotherapy on the primitive tumor and lymph node areas in case of good response to chemotherapy ( n= 2). The mean follow-up was 94 months; 78% of these patients were alive and in complete remission, 19% were in therapeutic failure, and 16% of them had metachronous metastases. The five-year-overall survival was 95%. Hyposialia and skin dystrophy were the most frequent late complications.
In univariate analyses, significant prognostic factors were cranial nerve invasion, intracranial invasion, and infra-temporal fossa invasion. In multivariate analysis, the most parsimonious model associated extension to the infratemporal fossa, endo-cranial extension, and initial therapeutic modality (treatment failures were less frequent with neoadjuvant chemotherapy (p= 0.22)). 
Conclusion: Treatment of nasopharyngeal carcinoma in children consists of chemotherapy and radiotherapy. Synchronous or metachronous metastases are common in this patient population. Modern radiotherapy techniques, including conformal radiotherapy with intensity modulation, are promising and could overcome toxicities in long-term survivors.
Prevalence of hearing loss in patients with sickle cell disease in the southeast of Iran
Authors: Miri-Aliabad Ghasem , Naderi Majid , Eghbali Aziz , Pirasteh Ebrahim , Hamzehpour Farzad , Erish Asma
Published: April 2024

Background: One of the complications of sickle cell disease (SCD) is hearing loss. The purpose of the present study is to determine the prevalence of hearing loss in SCD.
Materials and Methods: This is a descriptive-analytical cross-sectional study conducted on 100 patients with SCD in 2019-2020. All the patients underwent otololaryngological examination and audiometric tests to assess their hearing status. The type and severity of hearing loss were determined, the demographic information of the patients was recorded, and the data were analyzed using the SPSS software version 21, a Chi-square test, and the Kruskal-Wallis test. The P-values of < 0.05 were considered statistically significant.
Results: The mean age of the patients was 17.6 ± 10.8 years. Of them, 60% were male. Hearing loss was diagnosed in 26 patients (26%), 16 of whom had sensorineural hearing loss (SNHL) and 10 had conductive hearing loss (CHL). In terms of the disease severity, 12, 10, 3 and 1 patients had mild, moderate, severe and profound hearing loss, respectively. The mean age of the patients with SNHL was significantly higher than the median age of the subjects with CHL (p-value = 0.043). Also, the patients with hearing loss had no statistically significant difference in terms of the variables of age, gender, unilateral or bilateral ear involvement and type of SCD (p-value = 0.069).
Conclusion: This study revealed a hearing loss frequency of 26% among patients with SCD. Regular hearing assessment and timely treatment and rehabilitation measures are recommended for these patients.
Ulema and Santri Movement During the Indonesian Revolution of 1949-1950
Authors: Hasanah Uswatun
Published: April 2024

This article analyzes the power of Islam as a mobilizer against the invaders and defending the NKRI during the revolution in 1949-1950. This research illustrates that the Indonesian revolution is Islamic. Because Islam in that era became the power base in Indonesia. Apart from the majority Muslim population, Islam also dared to show its actions in resisting colonialism. Promoters in the Islamic movement were played by Ulema and Santri. The form of struggle of scholars during this revolution began with the call for jihad which aimed to revive the spirit of the Santri involved in the fisabilillah war. Then it was seen in his fatwa about the prohibition of Hajj to maintain Indonesia’s security from the threat of the invaders. While the struggle of the Santri by forming Islamic movements and fronts, namely the Hisbulloh and Sabilillah lascar fronts, which then attacked the British army headquarters in Surabaya. The Santri was also involved in the battle of November 10, 1945, which was incorporated with the Gerakan Pemuda Islam Indonesia (GPII). This research uses a historical methodology that includes four steps, namely heuristics, source criticism, interpretation, and historiography.
Keywords: Ulema and Santri, Islamic Movement, Indonesian Revolution 1949-1950
The Influence of Islamic Values on the Implementation of the Librarian Code of Ethics at the Library of Raden Intan State Islamic University Lampung
Authors: Silvia Indah , Pitri Rizka
Published: April 2024

This study discusses the influence of Islamic values on the implementation of the librarian code of ethics at the Raden Intan State Islamic University Library in Lampung. This study aims to determine whether there is a positive and significant influence between Islamic values on the code of ethics of librarians at the Raden Intan State Islamic University Library in Lampung. This is a type of descriptive quantitative research with data collection techniques through questionnaires and documentation. The data analysis in this study used several tests including normality tests, linearity tests, regression tests, correlation tests, and t hypothesis tests. Data analysis using Pearson’s Product Moment test statistics with the help of the SPSS V.22 statistical program with two research variables, namely the variable of Islamic values (X) and the variable of the librarian code of ethics (Y). The results showed a positive and significant influence between Islamic values on the code of ethics of librarians in the library of Raden Intan State Islamic University Lampung, with the results of a regression coefficient value of 0.0440 from a simple linear regression test. This means that there is a positive and significant influence between variable X and variable Y. The level of influence between variable X and variable Y is 37.7%. In other words, the amount of influence exerted by the variable of Islamic values on the librarian code of ethics is 37.7%, the rest is influenced by other factors.
Keywords: Islamic Values, Librarian Code of Ethics, Library
Job Description and Work Discipline (Study at the Riyadhus Sholihin Orphan and Dhuafa Boarding School in Bandar Lampung)
Authors: Mas Ayu Sovia , Dewi Asmara , Linda Shilmina Mazaya , Mas Ayu Zaituna , Zulyana Rahmi
Published: April 2024

The research aims to analyze the application of the job description of the boarding school management and its implications for work discipline at the Riyadhus Sholihin Orphan and Dhuafa Boarding School in Bandar Lampung. This research uses Dessler’s theory of job description indicators and a descriptive qualitative approach. Data collection was done by conducting interviews, observation, and documentation. Data analysis was carried out by reducing data, after which it was presented in the form of descriptions and verified by conclusion. The results of this study indicate the success of job descriptions and their implications for work discipline that can be seen through job identification, job summary, duties and responsibilities, authority, work standards, working conditions, and job specifications.
Keywords: job description, work discipline, boarding school
The Utilization of Social Media by Generation Z in Information Seeking: A Systematic Review
Authors: Setio Devi Katrin , Nurkamilah Siti , Roseliana Mazidah Zahrina , Ilmi Bachrul , Setiawan Saefullah Rahmat , Iridayanti Kurniasih Rr. , . Nurlistiani
Published: April 2024

The aim of this study is to identify the use of social media by Generation Z (Gen Z) in information seeking. This study employs a systematic review method with planning, implementation, and reporting phases. The databases utilized in this research are Google Scholar and Portal Garuda, with a publication timeframe of the last 10 years (2013-2023). The search yielded a total of 85 articles. After the elimination process, there were a total of 10 articles analyzed in this study. The research results indicate that Gen Z uses social media to seek information related to health, education, entertainment, and religion. Some Gen Z validates the information they obtain on social media, while others do not. The Ellis and Kuhlthau, information-seeking behavior (ISB) model is used to elucidate the information-seeking patterns of Gen Z. This systematic review is expected to serve as a consideration for educators and policymakers that social media can be used as a tool in the integration of formal and non-formal education.
Keywords: generation Z, information seeking, social media
Application of a Gender Responsive Approach in Building a Critical Literacy Culture in the Digital Age
Authors: Martania Mira , Bukhari Muslim Ahmad , Hawari Nadirsah , Rodiah Efa
Published: April 2024

In an increasingly digital era, access to information and digital media has become an important part of everyday life. Developments in the field of communication and technology information have open doors for interacting with media and accessing various source information quickly and easy. In everyday life, gender consideration is important to ensure inclusion, equality, understanding critical issues in the society, gender sensitivity, and its relevance in coping with gender inequality in digital literacy. In this research, qualitative approach is used and participants are individuals from various backgrounds. actively usingdigital media and have information literacy. Thematic approach is used to analyze the collected data. Gender sensitive approach is used to build culture understanding which is critical in the digital era and is a strategic step to overcome complex challenges that appear along with the development of technology. The method described covers gender analysis, education, development curriculum, and gender sensitive content production. However application method also found this as a problem like uneven accessibility, and there aretechnical challenges also. This study aims to increase awareness regarding gender sensitivity in digital literacy, to influence the societyto work the same cause for gender conscious in the digital era. With the use of this method we can create an environment where people from all gender types can develop skills, participate in various digital media, and can face challenges that arise in the digital era.
Keywords: literacy , digital era, gender, society
Literacy Culture About Sociology of Contemporary Religious Texts: A Study of Interpretation of The Quran in Indonesia
Authors: Rosa Andi , Shoheh Muhamad
Published: April 2024

Quraish Shihab’s role in modern Quranic interpretation in Indonesia is the backdrop explanation for the choice of this article’s major object of research. His work was often studied in academics in the field of Quranic interpretation and Indonesian Islam in the early stages of the development of theme interpretation in this country. This article aims to provide a solution to the research question: is the substance orientation of the thematic interpretation in books by Quraish Shihab regarding sociologists, in accordance with the theory of thematic interpretation? Content analysis and comparative methodologies are employed. Al-lawn wa al-ittijâh, the style or approach and direction of interpretation, serve as the foundation for content analysis. According to the research presented in this article, Quraish Shihab’s theme interpretation analysis in the field of sociology may be divided into three categories: internal analysis, extrinsic analysis, and study of the findings of earlier researchers. There are 18 types of analysis, with the following details: 12 of them (67%) include internal analysis, 2 (11%) extrinsic analysis, and 4 (22%) analysis based on the opinions of prior researchers. Quraish Shihab prioritizes interpretations that are implications of the themes discussed in order to be a workable solution in the contemporary context, based on the spirit of the Quran, while Dawam Rahardjo and Nur Kholis Setiawan prioritize interpretations that are implications of the themes discussed. Quraish Shihab also explains more about the ontological aspects of the themes he discusses and relates them to various internal aspects of the themes. The sociological interpretation of the Qur’an represents a method of fusing scientific and religious literature. The concern with the process of the relationship between the Qur’an and science, according to a number of experts in the field of science integration in the Indonesian Islamic community, is that science is justified by verses from the Quran even though scientists were the ones who discovered it. Even “possibly” a scientific theory cannot “read” the text of the Quran. Even if science and the Qur’an were on equal footing, neither could adequately explain how the Qur’an and nature are comprehended. In light of this, it is unnecessary to emphasize that the Quran is a source of knowledge.
Keywords: contextualization of comparative interpretation in a holistic manner, implications of thematic interpretation
The One Donors One Space-Based Da'wah Communication Movement in Lampung Province
Authors: Prastiwi Herliana , Yanti Fitri , Nasor M , Jauhari Tontowi
Published: April 2024

The awareness about the importance of sharing among the society has become a motivation for the Teras Komunal Community in the Province of Lampung to cultivate compassion towards others. Society often perceives sharing as something that only wealthy people do, and this cannot be denied due to people’s economic conditions and lack of knowledge. Teras Komunal, as a driver of social activities, strives to enhance the compassion and well-being of the community through a religious-based social movement called “One Donors One Space.” This research is conducted as a qualitative descriptive study using observation, interviews, and focus group discussions (FGD) as research methods. This research aims to analyze the communication movement of the Teras Komunal Community’s Da’wah based on the concept of “One Donor One Space” in the Province of Lampung, to enhance the awareness of the importance of sharing and the well-being of society. The research findings indicate that the da’wah communication movement carried out by Teras Komunal, based on the concept of “One Donor One Space” in the Province of Lampung, involves community empowerment through training and mentoring programs as efforts to improve the economy and raise awareness among the people regarding the significance of maximizing the potential of zakat, infaq, and sedekah.
Keywords: Da’wah communication, community, Teras Communal, community empowerment
The Impact of History on Literacy Culture in Indonesian Education During Society 5.0
Authors: Ayu Setianingrum Diah , Hadiati Eti , Purwanti Nasution Sri
Published: April 2024

This study investigates the significant influence of history on the development of a strong literacy culture within the Indonesian education system, particularly in the setting of Society 5.0. The relationship between historical knowledge and literacy development is investigated through literature research, demonstrating how history plays an important role in cultivating critical thinking abilities, generating empathy, and nurturing cultural understanding. The integration of history into literacy education is studied by merging multiple research found in journal articles, books, scientific papers, and so on, emphasizing the importance of educational components, teacher training, and collaborative efforts among educators, historians, and literacy experts. This particular study also discusses the challenges and opportunities that arise in this endeavor, while underscoring the long-term benefits of integrating history and literacy education within the era of Society 5.0. Finally, this study emphasizes the importance of embracing history in developing a strong literacy culture that empowers Indonesian students in an ever-changing educational setting.
Keywords: history, literacy culture, society 5.0
Optimization Of The Use Of Open Library Applications In Supporting Information Resources At Telkom University Bandung Library
Authors: Rizky Pratama Rahmad , . Misroni
Published: April 2024

Today’s technology is growing rapidly, considering quality and quantity, this case explains the role of the library. Libraries must be able to adjust to the needs of users quickly and effectively, therefore libraries are required to be at least dexterous in using technology. In terms of digital literacy, librarians must be able to understand and use various sources of information and digital media to meet the needs of people’s lives. The development of an “Open Library “ can be based on how to develop library-based information technology to continue to improve library services, collections, and databases. Open Library is a facility that can be used by the academic community of Telkom University and the general public. Therefore, this study is based on the optimization of the use of the Open Library Application Telkom University of Bandung, and in this case study was conducted directly in the library to see the extent to which this application is used optimally and used several ways of collecting data. One of them interviews with sources in the library.
Keywords: library, technology, librarian, digital
Features of Assessment the Carbon Footprint in Agriculture: Comparative Analysis of Methodological Approaches
Authors: Krasnoyarova Bella A. , Nazarenko Anton E. , Plutalova Tatyana G. , Sharabarina Sofya N.
Published: April 2024

The study of the components of the carbon balance and the possibilities of its regulation for different types of land use is an urgent scientific task within the framework of the global problem of increasing concentrations of greenhouse gases in the atmosphere and the development of the concept of carbon neutrality. In this article, an assessment of the carbon footprint of the farm was carried out based on an analysis of the capabilities of carbon calculators Cool Farm Tool, AgRe-Calc, Farm Carbon and Ex-Act V9.4, as well as the Methodology for quantitative determination of greenhouse gas absorption volumes, approved by Order of the Ministry of Natural Resources of the Russian Federation No. 371 dated 05/27/2022. Calculations were carried out using the example of the farm located in the Burlinsky region of the Altai region. The results of the study showed that the largest carbon footprint of the considered farm is formed by the cultivation of flax, somewhat smaller by sun-flower and wheat crops, and the lowest by fodder crops. Differences in estimates based on different methods are recorded not only in the resulting total carbon footprints, but also in the structure of the carbon footprint for each crop. In general, in Russia and abroad there are different approaches to determining the carbon footprint. The approach used in carbon calculators assumes that all carbon generated in one way or another during economic activity forms a carbon footprint, while the 2022 methodology of the Ministry of Natural Resources also takes agriculture into account as an important sink and carbon reservoir.
The Influence of Natural and Anthropogenic Factors on the Formation of the Microelement Composition of Burozems of Reinecke Island
Authors: Latysheva Larisa A.
Published: April 2024

The role of natural and anthropogenic factors in the formation of the microelement composition of the brown soils of the Reinecke Island is considered. Analysis of the concentration coefficients of heavy metals in the island brown soils showed that during soil formation, active accumulation occurs in the surface horizons of Zn, Cu, Cd and Co. The research results indicate the prevailing influence of soil formation features on the content and distribution of heavy metals in areas remote from the coast. As we approach the coastal zone, beloved by tourists for recreation, the content of Zn, Cu, Cd increases significantly in the surface layer of the island's brown soils, which is probably due to the local anthropogenic impact that takes place there. The data on the profile distribution of heavy metals in the studied brown soils reflect the intensity of the processes of humus formation occurring in the profile of brown soils and indicate the affinity of Pb, Cd to organic complexes. This is confirmed by the presence of significant positive correlation coefficients between organic matter and Pb and Cd content. The role of physical indicators of borozems on the fixation of a number of heavy metals in their profile is also noted. Quantitative indicators of Cr and Ni content are most determined by the distribution of the silty fraction. High values of the correlation coefficient between pH, the sum of exchange bases and the Mn content may indicate the influence of acid-base properties on its accumulation in the soil profile. Manganese hydroxide plays an important role in fixing Co in the brown soils of the island. The correlation between Co and Mn is estimated as noticeable.
Prawda w pracy dziennikarskiej. Moje doświadczenia
Authors: Boniecki Adam
Published: April 2024

Tekst przypomina – za kodeksami etyki dziennikarskiej – zasady prawdziwości przekazu medialnego oraz poszukiwania i publikowania prawdy. Tymczasem autor podaje przykłady manipulowania faktami („prawdą”), trudności w docieraniu do prawdy.
Prevalência de motivos e percepção de efeitos adversos relatados após a automedicação de aines e analgésicos em estudantes de publicidade e propaganda e jornalismo do centro universitário estácio de ribeirão preto
Authors: Laurito Drighetti Mateus
Published: April 2024

Introdução: os antiinflamatórios não-esteroidais (AINEs) e analgésicos são medicamentos utilizados para a melhora da dor e da inflamação, com uso prevalente por estudantes universitários.
Objetivo: análise do uso indiscriminado e efeitos colaterais desenvolvidos pelo uso de medicamentos das classes dos fármacos AINEs.
Metodologia: o presente artigo trata-se de um estudo quantitativo transversal, realizado por meio de um questionário autoaplicado entre os estudantes dos cursos de Publicidade e Propaganda e Jornalismo do Centro Universitário Estácio de Ribeirão Preto, com avaliação descritiva dos fatos.
Resultados: a partir do levantamento dos dados, foi notado que todos os estudantes dos cursos supracitados já se automedicaram com AINEs. Também foi constatado que a principal influência para o uso do medicamento escolhido foi indicação de pessoas próximas. Foram ainda identificados a sonolência como principal efeito adverso, dor como maior motivo para o uso e a dipirona como o medicamento mais frequentemente usado.
Conclusão: os resultados em sua maior parte condisseram com as expectativas dos autores com base em consultas bibliográficas.
Analysis of the residual magnetization of the outer rings of the bearings of the axle box assembly of the wheelset when demagnetizing them on the UMDP-01 installation
Authors: Otoka Aleksandr , Lyah Aleksey , Holodilov Oleg
Published: April 2024

Objective: to compare the readings of the residual magnetization of the outer ring of the bearing with its different orientation with respect to the magnetizing field on the example of the UMDP-01 installation. To show in practice the inefficiency of using the technology of demagnetization of the outer rings of the bearings of axle boxes when they are located in a horizontal plane. Methods: comparison of the obtained values of the residual magnetization by direct measurements during demagnetization of the outer rings in the horizontal and vertical planes with respect to the magnetic field. In practice, the same conditions for magnetization and demagnetization of the same outer ring were observed by passing a pulsed current through the solenoid and the contact rod in the magnetization mode and gradually reducing the alternating current in the solenoid for the demagnetization mode. Results: the experiment showed that the values of the residual magnetization of the outer ring during the full cycle of its demagnetization in the horizontal plane on the UMDP-01 installation are higher than when it is demagnetized in the vertical plane. The vertical placement of the ring in the center of the solenoid allowed it to be demagnetized from the first time in position A with an incomplete demagnetization cycle. Practical significance: the article shows that the technology of demagnetization of bearing rings in the horizontal plane, as required by the operating manual 9402.00.000 RE, often leads to a violation of the requirements of regulatory documents in terms of permissible values of residual magnetization. Demagnetization of the outer rings in the vertical plane will lead to full satisfaction of the requirements of regulatory documents, increase the productivity of magnetic powder control in general by reducing the demagnetization cycle and simplifying technological transitions associated with the complexity of installing the object of control in the horizontal plane.
Pulmonary Hypertension in Pregnancy: A Cardiological Approach to Maternal Outcomes as well as Neonatal and Therapeutic Management
Authors: Yusa Zainur Hafiz , Maulana Iqbal
Published: April 2024

Highlights:
1. Pulmonary hypertension is threatening to both the mother and the infant in the womb.
2. This report discusses the complexity of physiological changes in pregnant women with pulmonary hypertension.
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Abstract
Background: Maternal morbidity and mortality with pulmonary hypertension in pregnancy usually occur during labor until early postpartum. Historical reports have shown mortality rates as high as 30–56%. We report a 32-year-old female patient pregnant with her second child, with complaints of bleeding from the birth canal since 1 hour before admission to the hospital and a history of atrial septal defect type secundum.
Case presentation: The patient was diagnosed with G2P1A0, 16–17 weeks pregnant, with death conception, thrombocytopenia, and ASD secundum with pulmonary hypertension. The patient was planned for dilation and curettage by the obstetrics and gynecology departments. As a result of consultation with the cardiology department, medication management was given, and the decision to tolerate CRI IV very high-risk surgery was given.
Conclusion: Despite progress, pregnancy remains poorly tolerated in cases of pulmonary hypertension. Management should remain focused on contraceptive counseling and offering early termination when pregnancy does occur
Factors of stunting in toddlers (Analytical Study in the Work Area of the Tena Teke Health Center, Southwest Sumba, NTT)
Authors: Ina Florensia Anjela , Azisah Nabila Nur , Alim Andi , Kadir Erni
Published: April 2024

Stunting is a nutritional problem that hurts the quality of life of children in achieving optimal growth and development according to their genetic or hereditary potential. This study aims to determine the relationship between mother's knowledge, food intake, and history of LBW with stunting in toddlers at the Tena Teke Health Center, Southwest Sumba Regency, NTT in 2022. This study used a survey method with a cross-sectional study design. A sample of 233 people was taken using a non-probability sampling technique (accidental sampling). Data were analyzed through editing, coding, tabulation, and data entry processes. Knowledge instruments were tested for validity and reliability, while instruments for food intake, history of LBW, and stunting were considered valid and reliable because they were standardized by the Indonesian Ministry of Health. The results showed that there was no relationship between maternal knowledge (p=0.504) and food intake (p=0.137) with the incidence of stunting in toddlers and there was a relationship between history of LBW and stunting in toddlers (p=0.000). This study concludes that there is no relationship between maternal knowledge and food intake with the incidence of stunting in toddlers and there is a relationship between a history of LBW and the incidence of stunting in toddlers. It is necessary to increase the mother's knowledge about nutrition during pregnancy to prevent LBW. Future studies should consider external factors that could influence the results of the study.
Students Perceptions of Cigarette, Graphic Health Warnings, Fast Food Consumption, and Gadget Use On Physical Activity (Evidence-Based For Health Promoting University Program Recommendations)
Authors: Wibowo Yoga Putra , Puspitasari Regista Tri , Inaya Arneta Meihua , Anhar Vina Yulia , Noor Ihya Hazairin , Tarigan Dominicha Ernalem
Published: April 2024

Based on BPS data, consumption of cigarettes and e-cigarettes by teenagers over 15 years old decreased by 2.62% from the previous year, but it still has the potential to be dangerous. Adolescent health is quite worrying considering that teenagers are the main figures who can carry forward the vision for the future. The aim of this research is to obtain empirical evidence and appropriate strategies for implementing the HPU program. The method used is quantitative, through a survey with Franken-wallen incidental sampling, respondents are students pursuing higher education in 3 districts/cities, namely Banjar Regency, Banjarmasin City and Banjarbaru City. The survey was conducted from September to October (2 weeks) online. The results of this study show that cigarette and e-cigarette consumption is quite low, but respondents' perceptions regarding are still comprehensive (71%), including regarding graphic health warnings on cigarette packaging (80.1%). Interest in consuming fast food tends to be high (64.2%), who regularly consume fruit and vegetables (37.5% and 33.5%). The use of gadgets among students is very high (58%) and complaints regarding CVS also appear (45.5%). To support HPU, a specific action plan is needed, especially to strengthen understanding of the impact of consumption of cigarettes and so on.
Tantangan Berkelanjutan: Problematika Guru dalam Penerapan Kurikulum Merdeka Pada Mata Pelajaran Sejarah
Authors: Anggriani Nurul Mila , Putro Herry Porda Nugroho , Sriwati Sriwati
Published: April 2024

The Merdeka Curriculum represents an evolution from the 2013 Curriculum, introducing several changes aimed at providing schools, teachers, and students with opportunities to innovate, improvise, and negotiate for independent and creative learning. This research aims to investigate the implementation of the Merdeka Curriculum, highlighting challenges and efforts in teaching history. The research methodology utilized is descriptive qualitative, employing data collection techniques such as observation, interviews, and document analysis. Data analysis involves data reduction, presentation, and drawing conclusions, with validity ensured through measures of credibility, transferability, dependability, and confirmability. The findings reveal that Vocational High School 2 Banjarmasin has adopted the Merdeka Curriculum since 2021, emphasizing learning to generate products and services. Intracurricular learning is categorized into regular classroom sessions and extracurricular learning activities. The Project to Strengthen the Profile of Pancasila Students (P5) is conducted for a month outside regular teaching hours, with teachers independently preparing teaching materials. Teachers encounter various challenges in implementing the Merdeka Curriculum, including difficulties in analyzing learning outcomes, formulating learning objectives, constructing the flow of learning objectives, developing teaching modules, and selecting appropriate teaching media and methods. Additionally, limitations in technology, student textbooks, and classroom space contribute to these challenges. Efforts to address the obstacles in implementing the Merdeka Curriculum involve collective commitment, specialized training such as upskilling sessions and subject teacher collaboration activities, as well as enhancements to educational facilities and infrastructure. In conclusion, teachers must adapt to curriculum changes, overcome implementation obstacles, and possess the flexibility to ensure the effectiveness of curriculum implementation at Vocational High School 2 Banjarmasin.
Radiomics Machine Learning Analysis of Clear Cell Renal Cell Carcinoma for Tumour Grade Prediction Based on Intra-tumoural Subregion Heterogeneity
Authors: Alhussaini Abeer J. , Steele J. Douglas , Jawli Adel , Nabi Ghulam
Published: April 2024

Background: Renal cancers are among the top ten causes of cancer-specific mortality, of which the ccRCC subtype is responsible for most cases. The grading of ccRCC is important in determining tumour aggressiveness and clinical management. Objectives: The objectives of this research were to predict the WHO/ISUP grade of ccRCC pre-operatively and characterise the heterogeneity of tumour sub-regions using radiomics and ML models, including comparison with pre-operative biopsy-determined grading in a sub-group. Methods: Data were obtained from multiple institutions across two countries, including 391 patients with pathologically proven ccRCC. For analysis, the data were separated into four cohorts. Cohorts 1 and 2 included data from the respective institutions from the two countries, cohort 3 was the combined data from both cohort 1 and 2, and cohort 4 was a subset of cohort 1, for which both the biopsy and subsequent histology from resection (partial or total nephrectomy) were available. 3D image segmentation was carried out to derive a voxel of interest (VOI) mask. Radiomics features were then extracted from the contrast-enhanced images, and the data were normalised. The Pearson correlation coefficient and the XGBoost model were used to reduce the dimensionality of the features. Thereafter, 11 ML algorithms were implemented for the purpose of predicting the ccRCC grade and characterising the heterogeneity of sub-regions in the tumours. Results: For cohort 1, the 50% tumour core and 25% tumour periphery exhibited the best performance, with an average AUC of 77.9% and 78.6%, respectively. The 50% tumour core presented the highest performance in cohorts 2 and 3, with average AUC values of 87.6% and 76.9%, respectively. With the 25% periphery, cohort 4 showed AUC values of 95.0% and 80.0% for grade prediction when using internal and external validation, respectively, while biopsy histology had an AUC of 31.0% for the classification with the final grade of resection histology as a reference standard. The CatBoost classifier was the best for each of the four cohorts with an average AUC of 80.0%, 86.5%, 77.0% and 90.3% for cohorts 1, 2, 3 and 4 respectively. Conclusion: Radiomics signatures combined with ML have the potential to predict the WHO/ISUP grade of ccRCC with superior performance, when compared to pre-operative biopsy. Moreover, tumour sub-regions contain useful information that should be analysed independently when determining the tumour grade. Therefore, it is possible to distinguish the grade of ccRCC pre-operatively to improve patient care and management.
Peter Chew Sum: Beyond Newton Sum in Quadratic Root Function Computations
Authors: Chew Peter
Published: April 2024

This study provides a comprehensive comparison of the Peter Chew Sum method and Newton's Sum in Quadratic Root Function Computations. Both methods offer significant advancements by alleviating the need for memorization of multiple formulas. However, when confronted with higher-order quadratic root functions such as the calculation of power 33. Newton's Sum method proves cumbersome due to its requirement of all previous answers for final computation, leading to increased steps and error risks. In contrast, the Peter Chew Sum method simplifies the computational process by requiring only a few previous answers, resulting in a more straightforward series of operations. We contextualize our analysis within the historical progression of mathematical techniques, highlighting the transformative leap represented by the Peter Chew Sum method in quadratic root function computations. Peter Chew Sum addressing the limitations of Newton's Sum , especially concerning higher-order functions such as the calculation of power 256. Furthermore, study demonstrates that the innovative approach of the Peter Chew Sum method not only simplifies complex computations but also fosters enhanced conceptual understanding among students. In conclusion, study findings underscore the profound impact of the Peter Chew Sum method on quadratic root function computations.
Impact of Oncogenic Changes in p53 and KRAS on Macropinocytosis and Ferroptosis in Colon Cancer Cells and Anticancer Efficacy of Niclosamide with Differential Effects on These Two Processes
Authors: Nguyen Nhi T. , Sennoune Souad R. , Dharmalingam-Nandagopal Gunadharini , Sivaprakasam Sathish , Bhutia Yangzom D. , Ganapathy Vadivel
Published: April 2024

Mutations in p53 and KRAS are seen in most cases of colon cancer. The impact of these mutations on signaling pathways related to cancer growth has been studied in depth, but relatively less is known on their effects on amino acid transporters in cancer cells. This represents a significant knowledge gap because amino acid nutrition in cancer cells profoundly influences macropinocytosis and ferroptosis, two processes with opposing effects on tumor growth. Here we used isogenic colon cancer cell lines to investigate the effects of p53 loss and KRAS activation on two amino acid transporters relevant to macropinocytosis (SLC38A5) and ferroptosis (SLC7A11). Our studies show that the predominant effect of p53 loss is to induce SLC7A11 with resultant potentiation of antioxidant machinery and protection of cancer cells from ferroptosis whereas KRAS activation induces not only SLC7A11 but also SLC38A5, thus offering protection from ferroptosis as well as improving amino acid nutrition in cancer cells via accelerated macropinocytosis. Niclosamide, an FDA-approved anti-helminthic, blocks the functions of SLC7A11 and SLC38A5, thus inducing ferroptosis and suppressing macropinocytosis with resultant effective reversal of tumor-promoting actions of oncogenic mutations in p53 and KRAS. These findings underscore the potential of this drug in colon cancer treatment.
Carotid Plaques and Hypertension on the Risk of Cardiovascular Disease and All-Cause Mortality
Authors: Dzenkeviciute Vilma , Adomavicius Tadas , Tarulyte Gabriele , Rinkuniene Egidija , Kasiulevicius Vytautas , Badariene Jolita
Published: April 2024

Background: Both hypertension and carotid atherosclerosis are independent risk factors for cardiovascular disease. Understanding their combined impact could enhance risk assessment and management strategies.
Hypothesis: We hypothesized that the synergistic effects of hypertension and carotid plaques would increase the risk of both cardiovascular events and all-cause mortality.
Methods: A follow-up study was conducted at the Preventive Cardiology department of Vilnius University Hospital Santaros klinikos between 2012 and 2021. The study recruited participants aged 40-60 who did not have overt CVD and were part of the Lithuanian High Cardiovascular Risk primary preventive program. The study collected demographic and clinical data, including an ultrasound assessment of carotid plaque. The participants were monitored for 4-10 years for CVD events and all-cause mortality.
Results: Among 6,138 participants, 954 (16%) experienced cardiovascular disease (CVD) events. The presence of carotid plaque on both sides was significantly associated with CVD events, myocardial infarction, and all-cause mortality. However, the combination of hypertension and carotid plaque did not significantly increase the risk for CVD events, stroke, or all-cause mortality.
Conclusion: The combination of hypertension and carotid plaque did not significantly increase the risk of CVD events or all-cause mortality. CV events depend on the spread of the atherosclerosis process in the carotid vessels.
The Impact of Nature-Based Outdoor Learning Landscape on STEAM Concept Formation of Preschoolers: A Scoping Review
Authors: Trina Nazia Afrin , Monsur Muntazar , Cosco Nilda , Shine Stephanie , Loon Leehu , Mastergeorge Ann
Published: April 2024

Children are inherently curious about everything they encounter, making the early years a perfect time for STEAM (science, technology, engineering, arts, and math) investigations. An outdoor learning environment can influence STEAM concept formation of preschoolers with intentional design that offer STEAM learning affordances. Despite the rising interest in early STEAM education, there is still limited literature on how the outdoor environment may influence STEAM learning behaviors of preschoolers (3-5 years old). This scoping review intends to evaluate the existing knowledge regarding the physical factors that contribute to STEAM learning affordances in an outdoor environment for children aged 3 to 5. The review included studies from the last twenty years. This scoping review was conducted in accordance with the criteria outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR). For this scoping review, 843 citations were discovered across four databases (JSTOR, Scopus, EBSCOhost, and Web of Science), ProQuest, and Google Scholar, and 31 articles were considered eligible for inclusion. Through the synthesis of information from those 31 studies, a list of STEAM learning behaviors of children and STEAM activity-supportive settings were identified that may positively influence preschoolers' STEAM concept development.
Experimental Procedure to Study the High Speed Orthogonal Cutting of Unidirectional GFRP
Authors: Panico Martina , Boccarusso Luca , Formisano Antonio , Villani Giuseppe , Langella Antonio
Published: April 2024

The aim of this paper is to establish a valid procedure for better understanding all the phenomena associated with the high-speed machining of Glass Fibre Reinforced Plastic (GFRP) composites. Both rectangular and circular specimens were machined at high speeds (up to 50 m/min) in order to understand what occurred for all values of fiber orientation angles during machining operations. An innovative testing methodology was proposed and studied to investigate the phenomenon of burr formation and thus understand how to avoid it during machining operations. To this end, the forces arising during the machining process and the roughness of the resulting surface, were carefully studied and correlated with the cutting angle. Additionally, the cutting surface and chip morphology formed during cutting tests were examined using a high-speed camera. Close correlations are found between the variations of the cutting forces' signals and the trends of the roughness and the morphology of the machined surface.