bluuebunny/crossref_metadata_2025 huggingface dataset:
Increasing meat product functionality by the addition of milled flaxseed Linum usitatissimum
Authors: Zając Marzena , Kulawik Piotr , Tkaczewska Joanna , Migdał Władysław , Pustkowiak Henryk
Published: November 2016

BACKGROUND

Functional meat products are still rare on the market because it is difficult to incorporate new ingredients and obtain both a healthy and acceptable product. Flaxseed is known for its beneficial properties and, in the present study, it was used as an ingredient in the production of homogenised and liver sausages (0%, 5% and 10% flaxseed addition).

RESULTS

Homogenised and liver sausages with the addition of 5% flaxseed were given the highest scores by the consumers, although the colour changed with the addition of flaxseed. The spreadability and hardness of the liver sausages increased with the addition of flaxseed, whereas the texture of homogenised sausages did not change. Addition of flaxseed improved the fatty acids profile from a health point of view for both products, as a result of increasing n‐3 fatty acids and overall polyunsaturated fatty acids content. Values for thiobarbituric acid reactive substances were higher in products with flaxseed and were observed to increase during storage.

CONCLUSION

The results of the present study indicate that it is possible to obtain products that are acceptable by consumers and, at the same time, are more healthy. A high level of α‐linolenic acid in the sausages at a level of addition of 5% allows the product to be labelled with information regarding their high omega‐3 fatty acid content. However, those products are more susceptible to oxidation. © 2016 Society of Chemical Industry
Identification of l‐carnitine and its impurities in food supplement formulations by online column‐switching liquid chromatography coupled with linear ion trap mass spectrometry
Authors: Wang Hang , Xie Sijun
Published: November 2016

The identification of impurities in l‐carnitine by mass spectrometry is difficult because derivative reagents or ion pair reagents are usually used to separate and increase the retention of l‐carnitine on the reversed‐phase column. In this study, four impurities including 3‐chloro‐2‐hydroxy‐N,N,N‐trimethylpropan‐1‐aminium, 3‐cyano‐2‐hydroxy‐N,N,N‐trimethylpropan‐1‐aminium, 3‐carboxy‐N,N,N‐trimethylprop‐2‐en‐1‐aminium, and 4‐chloro‐2,3,4‐trihydroxy‐N,N,N‐trimethylbutan‐1‐aminium were identified in l‐carnitine and its tablets by using two‐dimensional column‐switching high‐performance liquid chromatography coupled with linear ion trap mass spectrometry. The first column was a C8 column at a flow rate of 0.15 mL/min; the detection wavelength was 220 nm. The second column was an Acclaim Q1 column using a gradient elution program with aqueous 30 mM ammonium acetate (pH 5.0) and acetonitrile as the mobile phase at a flow rate of 0.5 mL/min. The mass fragmentation patterns and structural assignments of impurities were studied, and the quantitative validation of three impurities was further investigated. The linearity (r2) was found to be >0.99, with ranges from 0.2 to 50 ng/mL and 0.1 to 10 ng/mL. The method was used successfully for determination of impurities in five samples of l‐carnitine and tablets.
Investigation of the weak binding of a tetrahistidine‐tagged peptide to quantum dots by using capillary electrophoresis with fluorescence detection
Authors: Qin Haifang , Jiang Xiyuan , Fan Jie , Wang Jianpeng , Liu Li , Qiu Lin , Wang Jianhao , Jiang Pengju
Published: November 2016

Capillary electrophoresis with fluorescence detection was utilized to probe the self‐assembly between cyanine group dye labeled tetrahistidine containing peptide and CdSe/ZnS quantum dots, inside the capillary. Quantum dots and cyanine group dye labeled tetrahistidine containing peptide were injected into the capillary one after the other and allowed to self‐assemble. Their self‐assembly resulted into a measurable Förster resonance energy transfer signal between quantum dots and cyanine group dye labeled tetrahistidine containing peptide. The Förster resonance energy transfer signal increased upon increasing the cyanine group dye labeled tetrahistidine containing peptide/quantum dot molar ratio and reached a plateau at the 32/1 molar ratio. Additionally, the Förster resonance energy transfer signal was also affected by the increment of the interval time of injection and the sampling time. Online ligand exchange experiments were used to assess, the potential of a monovalent ligand of imidazole and a hexavalent ligand peptide, to displace surface bound cyanine group dye labeled peptide ligands from the quantum dots surface. Under optimal conditions, a linear relationship between the integrated peak areas and hexavalent ligand peptide was obtained at a hexavalent ligand concentration range of 0−0.5 mM. Therefore, the present assay has the potential to be applied in the online ligands detection.
Quality of life before and after different treatment modalities in peripheral facial palsy: A systematic review
Authors: Luijmes Robin E. , Pouwels Sjaak , Beurskens Carien H. G. , Kleiss Ingrid J. , Siemann Ietske , Ingels Koen J. A. O.
Published: November 2016

Objectives

A systematic review was conducted to investigate the effect of peripheral facial palsy (PFP) on the quality of life (QoL). Secondly, we investigated if different treatment modalities influence the QoL of patients with PFP.

Methods

A multidatabase systematic literature search was performed using the following databases: PubMed, Embase, MEDLINE, and The Cochrane Library from the earliest date of each database up to August 2015. The inclusion criteria were either prospective and/or retrospective cohort trials and/or case series measurement of QoL before and after treatment, patients with PFP (irrespective of etiology), and various treatment modalities (medication, physical therapy, botulinum toxin injections, and several types of surgical procedures). Two authors rated the methodological quality of the included studies independently using the Newcastle–Ottawa Quality Assessment Scale for nonrandomized studies.

Results

Two hundred fifty‐eight studies were found, of which 14 studies met the inclusion criteria. Most studies were assessed to be of fair to good methodological quality. The Cohen's κ (between author r.e.l. and s.p.) was 0.68. Eight different questionnaires were used to measure QoL, of which the Facial Clinimetric Evaluation scale was used most frequent. After different modalities, all studies showed significant improvements in terms of QoL.

Conclusions

This study found significant improvement when measuring QoL before and after different treatment modalities in patients with peripheral facial palsy. Future research should focus on patients with PFP due to the same etiology and use of valid QoL instruments for outcome measures. Laryngoscope, 127:1044–1051, 2017
Potassium titanyl phosphate laser welding following complete nerve transection
Authors: Bhatt Neel K. , Mejias Christopher , Kallogjeri Dorina , Gale Derrick C. , Park Andrea M. , Paniello Randal C.
Published: November 2016

Objectives/Hypothesis

Cranial nerve transection during head and neck surgery is conventionally repaired by microsuture reanastomosis. Laser nerve welding (LNW), using CO2 laser to spot‐weld the epineurium of transected nerve endings, has been shown in animal models to be a novel alternative to microsuture repair. This method avoids needle/suture material and minimizes instrumentation of the nerve. We hypothesized that potassium titanyl phosphate (KTP) laser would be superior to CO2 laser in repairing transected nerves. Using a rat posterior tibial nerve injury model, we compared CO2 laser, KTP laser, and microsuture reanastomosis.

Study Design

Animal study.

Methods

Animals underwent unilateral posterior tibial nerve transection. The injury was repaired by microsuture repair (n = 15), CO2 laser repair (n = 15), or KTP laser repair (n = 15). Weekly walking tracks were performed to measure functional recovery. Nerve segments were harvested for axon counting.

Results

At 6 weeks, the KTP LNW had the best functional recovery (92.4 ± 8.6%) compared to microsuture repair (84.5 ± 10.2%, difference 7.9%, 95% confidence interval [CI]: 0.84%‐14.96%). CO2 laser repair had a functional recovery of 86.8 ± 11.2%. KTP LNW had better axon recovery compared to transection/repair (difference 530.7 axons, 95% CI: 329.9‐731.5). Operative time for the microsuture repair was 18.2 ± 6.8 minutes, compared to 5.8 ± 3.7 minutes for the LNW groups (difference 12.4 minutes, 95% CI: 8.6‐16.2 minutes).

Conclusions

KTP, CO2, and microsuture repair all showed good functional recovery following complete transection of the posterior tibial nerve. Following complete nerve transection during head and neck surgery, KTP LNW may be a novel alternative to microsuture repair.

Level of Evidence

NA Laryngoscope, 127:1525–1530, 2017
Chronic parotitis with multiple calcifications: Clinical and sialendoscopic findings
Authors: Jáuregui Emmanuel , Kiringoda Ruwan , Ryan William R. , Eisele David W. , Chang Jolie L.
Published: November 2016

Objectives/Hypothesis

To characterize clinical, imaging, and sialendoscopy findings in patients with chronic parotitis and multiple parotid calcifications.

Study Design

Retrospective review.

Methods

Clinical history, radiographic images and reports, lab tests, and operative reports were reviewed for adult patients with chronic parotitis and multiple parotid calcifications who underwent parotid sialendoscopy.

Results

Thirteen of 133 (10%) patients undergoing parotid sialendoscopy for chronic sialadenitis had more than one calcification in the region of the parotid gland. Seven patients (54%) were diagnosed with immune‐mediated disease from autoimmune parotitis (positive Sjögren's antibodies or antinuclear antibodies) or human immunodeficiency virus (HIV) disease. The six patients (46%) who did not have an immune‐mediated disorder had most calcifications located anterior or along the masseter muscle. Eight of 13 patients (61%) had at least one calculus found in the parotid duct on sialendoscopy. Four patients (38%) had multiple punctate calcifications within the parotid gland, all of whom had either autoimmune parotitis or HIV. None of the proximal or punctate parotid calcifications posterior to the masseter were visualized on sialendoscopy.

Conclusions

Chronic parotitis in conjunction with multiple parotid calcifications is uncommon and was identified in 10% of our cohort. We contrast two classifications of parotid calcifications: 1) intraductal stones that cause recurrent duct obstruction and are often located within the main parotid duct along or anterior to the masseter and 2) punctate intraparenchymal parotid gland calcifications that are not visualized on sialendoscopy and may represent underlying inflammatory disease.

Level of Evidence

4 Laryngoscope, 127:1565–1570, 2017
Prevalence of polyp recurrence after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis
Authors: DeConde Adam S. , Mace Jess C. , Levy Joshua M. , Rudmik Luke , Alt Jeremiah A. , Smith Timothy L.
Published: November 2016

Objectives/Hypothesis

Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a disease process that is driven, in part, by intrinsic mucosal inflammation. Surgery plus continued medical therapy is commonly elected by medically recalcitrant, symptomatic patients. The objective was to evaluate the prevalence of nasal polyp recurrence up to 18 months after endoscopic sinus surgery (ESS) with congruent continuing medical management.

Study Design

Prospective, multicenter cohort of adult patients undergoing ESS for medically recalcitrant CRSwNP performed between August 2004 and February 2015.

Methods

All patients received baseline nasal endoscopy quantified using Lund‐Kennedy grading. All patients included for final analysis provided at least 6 months of postoperative endoscopy examinations. Multivariate analysis was used to identify risk factors for polyp recurrence.

Results

Three hundred sixty‐three CRSwNP patients having undergone ESS involving polypectomy were enrolled. A total of 244 (67%) participants had graded postoperative endoscopies with average of follow‐up of 14.3 ± 7.0 months. Surgery plus postoperative medical management significantly improved endoscopy total scores at 6 months (P < .001). The recurrence of nasal polyposis 6 months after ESS was 35% (68/197), compared to 38% (48/125) after 12 months, and 40% (52/129) after 18 months. Multivariate analysis identified both prior ESS (odds ratio [OR]: 2.6, 95% confidence interval [CI]: 1.5‐4.6; P = .001) and worse preoperative polyposis severity (OR: 1.4, 95% CI: 1.1‐1.8; P = .016) as risk factors for recurrent polyposis.

Conclusions

Polyp recurrence is common after ESS with control of polyps up to 18 months found in approximately 60% to 70% of patients. Investigation into both surgical and medical management strategies is warranted to improve upon the observed prevalence of recurrence.

Level of Evidence

2c. Laryngoscope, 127:550–555, 2017
TGF‐β antagonist attenuates fibrosis but not luminal narrowing in experimental tracheal stenosis
Authors: Antón‐Pacheco Juan L. , Usategui Alicia , Martínez Iván , García‐Herrero Carmen M. , Gamez Antonio P. , Grau Montserrat , Martínez Ana M. , Rodríguez‐Peralto José L. , Pablos José L.
Published: November 2016

Objective

Acquired tracheal stenosis (ATS) is an unusual disease often secondary to prolonged mechanical trauma. Acquired tracheal stenosis pathogenesis involves inflammation and subsequent fibrosis with narrowing of the tracheal lumen. Transforming growth factor‐β1 (TGF‐β) represents a pivotal factor in most fibrotic processes, and therefore a potential target in this context. The aim of this study is to analyze the role of TGF‐β as a target for anti‐fibrotic interventions in tracheal stenosis.

Methods

Human stenotic tracheobronchial tissues from patients with benign airway stenosis and normal controls from pneumonectomy specimens were analyzed. Tracheal stenosis was induced in adult NZ rabbits by a circumferential thermal injury to the mucosa during open surgery and re‐anastomosis. Rabbits were treated postoperatively with a peritracheal collagen sponge containing a TGF‐β peptide antagonist (p17) or vehicle. Fibrosis was determined by Masson's trichrome staining, and smooth muscle cell α‐actin+ (α‐SMA+ Confirm accuracy.) myofibroblasts, connective tissue growth factor (CTGF), and p‐Smad2/3 expression by immunohistochemistry.

Results

Human and rabbit stenotic tissues showed extensive submucosal fibrosis, characterized by significantly increased α‐SMA+ myofibroblasts and CTGF expression. In human stenotic lesions, increased p‐Smad2/3+ nuclei were also observed. p17 treatment significantly reduced the fibrotic thickness, as well as the density of α‐SMA+ myofibroblasts and CTGF+ cells in rabbit stenotic lesions, but failed to improve the luminal area.

Conclusion

ATS is characterized by a TGF‐β dependent fibrotic process, but reduction of the fibrotic component by TGF‐β1 antagonist therapy was not sufficient to improve tracheal narrowing, suggesting that fibrosis may not be the main contributor to luminal stenosis.

Level of Evidence

NA. Laryngoscope, 127:561–567, 2017
Does treatment of paradoxical vocal fold movement disorder decrease asthma medication use?
Authors: Kramer Scott , deSilva Brad , Forrest L. Arick , Matrka Laura
Published: November 2016

Objectives/Hypothesis

To determine whether diagnosis and treatment of paradoxical vocal fold movement disorder (PVFMD) leads to decreased asthma medication use. Secondary objectives include determining initial rate of asthma medication use, characterizing symptom improvement, and correlating with pulmonary function testing (PFT).

Study Design

Prospective observational study.

Methods

Patients newly diagnosed with PVFMD at a single institution were recruited to participate. Medication questionnaires were completed at the initial visit, at the first return visit for therapy, and at 6 months. PFTs were reviewed when available.

Results

Sixty‐six patients were recruited; the study was closed early because findings reached significance. Fifty‐six patients (85%) were taking asthma medication at presentation. Forty‐four patients presented with PFTs, and two‐thirds were normal. Forty‐two patients completed follow‐up questionnaires; 79% decreased asthma medication use (P < .001), and 82% reported symptom improvement. Seventy‐seven percent of patients participated in therapy and 23% did not, with equal rates of decrease in asthma medication use between these groups. Outcomes did not vary based on PFT pattern (i.e., obstructive vs. nonobstructive, P = .75).

Conclusions

Diagnosis and treatment of PVFMD lead to a decline in asthma medication use. This decrease occurred alongside symptom improvement and irrespective of PFT findings. Use of asthma medication in this patient population is high, at 85%.

Level of Evidence

4. Laryngoscope, 127:1531–1537, 2017
Sedimentary oxygen dynamics in a seasonally hypoxic basin
Authors: Seitaj Dorina , Sulu‐Gambari Fatimah , Burdorf Laurine D. W. , Romero‐Ramirez Alicia , Maire Olivier , Malkin Sairah Y. , Slomp Caroline P. , Meysman Filip J. R.
Published: November 2016

Seasonal hypoxia refers to the oxygen depletion that occurs in summer in the bottom water of stratified systems, and is increasingly observed in coastal areas worldwide. The process induces a seasonal cycle on the biogeochemistry of the underlying sediments, which remains poorly quantified. Here, we investigated the sedimentary oxygen consumption within Lake Grevelingen (The Netherlands), a saline coastal reservoir that is impacted by yearly recurrent bottom water hypoxia. Monthly sampling campaigns were conducted throughout 2012 at three sites along a depth gradient. Macrofauna sampling and sediment profile imaging demonstrated how summer hypoxia strongly impacts the benthic communities below 15 m of water depth. Benthic fluxes of oxygen, dissolved inorganic carbon, total alkalinity, and ammonium were determined by closed core incubations, while oxygen depth profiles were recorded by microsensor profiling of sediment cores. Our results reveal a pronounced seasonality in the sedimentary oxygen consumption. Low uptake rates in summer were caused by oxygen limitation, and resulted in the build‐up of an “oxygen debt” through the accumulation of reduced iron sulfides. Highest oxygen uptake rates were recorded in fall, linked to the reoxidation of the pool of iron sulfides in the top layer. However, uptake rates remained unexpectedly high during winter and early spring, likely associated with the oxidation of iron sulfides down to centimeters depth due to the electrogenic sulfur oxidation by cable bacteria. Overall, our results suggest that the sedimentary oxygen dynamic in seasonally hypoxic coastal systems is characterized by a strongly amplified “oxygen debt” dynamics induced by cable bacteria.
Reconstructing the seasonal dynamics and relative contribution of the major processes sustaining CO2 emissions in northern lakes
Authors: Vachon Dominic , Solomon Christopher T. , del Giorgio Paul A.
Published: November 2016

Lake CO2 emissions are an important component of the carbon balance of northern landscapes, yet the temporal dynamics of the underlying mechanisms sustaining CO2 emissions are less understood. Here, we reconstruct the major biotic and abiotic processes influencing CO2 dynamics over an annual cycle in three limnologically different lakes, using a combination of empirical measurements and process‐based modeling. Our results suggest that the relative importance of each process sustaining CO2 emissions is not only variable among lakes, but also highly variable among seasons within one lake. Spring CO2 emissions were largely sustained by the release of under ice accumulation (between about 50–100%), although photo‐chemical DOC mineralization and hydrologic CO2 loading were also relatively important. In summer, due to warmer temperature, pelagic and benthic metabolism were the main sources of CO2 emissions. In the fall, lake CO2 emissions were generally sustained by hydrologic CO2 inputs, while hypolimnetic CO2 accumulation and release also contributed to fall CO2 emission in the deepest lake. On an annual basis, lake CO2 emissions ranged between 21.4 g C m−2 yr−1 and 55.5 g C m−2 yr−1. Our results confirm that the major processes all contributed significantly to CO2 emissions, but their relative contributions were modulated by the seasonal patterns in climate and hydrology, and by differences in morphology and organic carbon inputs among lakes. These lake‐ and season‐specific features need to be considered both in the upscaling of lake processes at regional scales, and in predicting lake CO2 emissions under scenarios of climate and environmental change.
Lubrication effectiveness investigation on the friendly capped MoS2 nanoparticles
Authors: Wu Hongxing , Wang Liping , Dong Guangneng , Yang Shuncheng , Zhang Junfeng , Zhou Bin , Tang Zhengyi
Published: November 2016

The compatibility and effectiveness of nanoparticles with the existing additives in formulated oil are still unclear. In the present study, some lubricant additives were selected to modify nanoparticles to obtain friendly capped nano‐MoS2. Various polyisobutyleneamine succinimide (PIBS) concentrations were applied to investigate the lubrication effectiveness of capped nano‐MoS2. The results showed that the reduction in COF and wear volume of friendly capped nanoparticles without PIBS reached about 35% and 75% in comparison with those of the base oil respectively. However, the average coefficient of friction and wear volume loss of nano oil increased with PIBS concentration in the range of 0.05%–1%. By scanning electron microscope, energy‐dispersive X‐ray spectroscopy and X‐ray photoelectron spectroscopy analysis, it is identified that (i) MoS2 tribofilm was formed on the wear track for the oil with nano‐MoS2 and (ii) wear scar was smooth for nano‐MoS2 with low PIBS concentration and without PIBS, while it showed plowing wear when containing high PIBS concentration. Copyright © 2016 John Wiley & Sons, Ltd.
Exploring Consumer Insights in Wine Marketing: An Ethnographic Research on #Winelovers
Authors: Cuomo Maria Teresa , Tortora Debora , Festa Giuseppe , Giordano Alex , Metallo Gerardino
Published: November 2016

Nowadays social media offer a great opportunity to wineries in order to better understand their customers’ needs, both potential and actual. Especially for winelovers, their collective imagination, expectations, and lifestyle in terms of passion for wine can be continually supervised and used in brand strategies. By collecting these data on Instagram and analyzing them through a netnographic research, the purpose of the present study is to validate the emerging “map of identity” for winelovers as a basis of segmentation in the wine sector. In a second step, the accuracy of the profiles has been tested by distributing a questionnaire both to a specific community of winelovers and to a control group of self‐defined winelovers active on Facebook. The findings underline that winelovers’ identities could be better arranged considering their knowledge and awareness in consumption, even though they clearly represent a basis for further in‐depth researches, interested in exploring attitudes, values, and motivations of winelovers and wine consumers on the Web.
Influence of the Virtual Brand Community in Sports Sponsorship
Authors: Alonso Dos Santos Manuel , Calabuig Moreno Ferran , Rejón Guardia Francisco , Pérez Campos Carlos
Published: November 2016

This study explores how the virtual brand community (VBC) of soccer‐team supporters influences the brand's attitude toward sponsorship according to the theory of image transfer. The study provides a comparative analysis using both structural equation modeling (SEM) and qualitative comparative analysis (QCA). A total of 609 supporters of a professional, first‐division Spanish soccer team provide the data. The results from SEM support the importance of control, attitude toward the team, and identification variables. However, SEM cannot assure the usefulness of variables such as trust and opportunism when evaluating the resulting attitude toward the sponsor. The results from the fuzzy‐set QCA on the same data set show that not all variables are necessary conditions in order to influence sponsorship. The most relevant variables to obtain valid and useful results are control, attitude toward the team, and trust. The combination of attitude toward the team, identification, and trust is also valid. Attitude toward the team and trust variables are present in the two combinations of variables leading to a positive, favorable attitude toward the sponsor, thus reflecting their importance in marketing experts’ assessment of image transmission in professional teams.
Self or Simulacra of Online Reviews: An Empirical Perspective
Authors: Singh Vivek Kumar , Nishant Rohit , Kitchen Philip J.
Published: November 2016

Online user‐generated content includes various forms of computer‐mediated online reviews, ratings, and feedback. The impact of online consumer reviews has been widely studied particularly in e‐commerce, online marketing, and consumer behavior domains using text‐mining and sentiment analysis. Such studies often assume that consumer‐submitted online reviews truly represent consumer experiences, but multiple studies on online social networks suggest otherwise. Drawing from the social network literature, this paper investigates the impact of peers on consumer willingness to write and submit online reviews. An empirical study using data from “Yelp,” a globally used online restaurant review Web site, shows that the number of friends and fans positively impacts the number of online consumer reviews written. Implications for research and practice are discussed.
Examining the Effects of Online Social Networks and Organizational Learning Capability on Innovation Performance in the Hotel Industry
Authors: Palacios‐Marqués Daniel , Devece‐Carañana Carlos , Llopis‐Albert Carlos
Published: November 2016

The purpose of this paper is to explore the effects of online social networks and organizational learning capability on innovation performance. The paper is theory‐confirming. Theoretical relationships were tested using an empirical study of 202 four‐star and five‐star Spanish hotels. Results confirm that the introduction of online social network use for internal and external cognitive processes positively affects innovation performance. This study highlights the potential as well as the limitations of online social networks and organizational learning capability in promoting innovation capability. Businesses must consciously manage the assimilation and use of online social networks to benefit from them.
Factors for Elderly Use of Social Media for Health‐Related Activities
Authors: Parida Vinit , Mostaghel Rana , Oghazi Pejvak
Published: November 2016

Elderly individuals are increasingly using social media sites to access health‐related information. Using responses from 610 elderly individuals in Sweden to a large‐scale questionnaire survey, this study examines technology acceptance model and sociodemographic factors that positively influence elderly individuals’ use of social media for health‐related activities. The results show evidence of a positive association between general technology use experience, attitudes toward technology use, age, or gender, and the use of social media for health‐related activities. Technology attitudes strengthen the effect on social media use for health‐related activities regarding general use of technology, for older individuals, and among females.
Exploring How Video Digital Storytelling Builds Relationship Experiences
Authors: Pera Rebecca , Viglia Giampaolo
Published: November 2016

The purpose of the paper is to explore how digital storytelling enables a consumer relationship experience in online peer‐to‐peer communities. Within the value cocreation framework, digital storytelling is interpreted as an encounter communication practice where consumers adopt the role of storytellers and story receivers. This study adopts a qualitative multimethod approach to investigate the meanings contained in video stories and the linkage to relationship experience. A case study based on the Airbnb's social platforms was analyzed through the degrees‐of‐freedom analysis instrument (DFA) and through a systematic dimensional qualitative research called BASIC IDS (an acronym for behavior, affect, sensation, imagery, cognition, interpersonal relations, drugs, and sociocultural factors) to yield psychological valuable insights into the multidimensional construct of consumer relationship experience. The analysis unveils that, within the social media realm, storytelling enables rational, emotional, and relationship experiences. A relationship experience occurs when members of peer‐to‐peer communities, not only are rationally and emotionally engaged by the story, but are also moved to action going beyond a vicarious role‐taking process. Specifically, relatability, a shared sociocultural background, and the drug dimension conceptualize the consumer relationship experience. Implications build on the need for companies to enhance the power of stories through favoring consumers’ video making and integrating consumers’ flow of stories between multiple social media platforms.
Online Customer Service Reviews in Urban Hotels: A Data Mining Approach
Authors: Sánchez‐Franco Manuel J. , Navarro‐García Antonio , Rondán‐Cataluña Francisco J.
Published: November 2016

This study proposes a product feature‐oriented approach to the analysis of online guests’ reviews, and it analyzes the relationship between the most salient features and guests’ hotel rating in the online travel agencies environment. In particular, this research means to address the following research question: How can this understanding of these features help us to design desirable urban hotel experiences that guests really assess? This research employs a sample of 829 Spanish urban hotels and 19,318 reviews. These data, by extracting attributes that are mentioned differently by males or females, reveal the moderating role of gender on the influence of the main dimensions of hospitality services on hotel ratings.
Consumer Involvement in New Product Development: A Case Study from the Online Virtual Community
Authors: Xie Xuemei , Jia Yaoyang
Published: November 2016

In current dynamic networking era, firms face more pressure, such as increasing market competition, the shortening product development cycle, and consumers’ diverse needs. In the social media context, the emergence of online community provides a platform for consumer involvement in firms’ new product development (NPD). Accordingly, working with consumers via online community has become increasingly important to the development of new products and the improvement of firms’ innovativeness. This paper aims to explore the motivations for consumer involvement in firms’ NPD via online community and to examine the relationships between different combinations of motivations and NPD using the method of fuzzy set quality comparative analysis (fsQCA). The motivations for consumer involvement in firms’ NPD identified by the grounded theory method are as follows: (1) consumers’ needs, (2) compensation, (3) personal interest, (4) an open and flexible online community network, and (5) firms’ trustworthiness. In this study, the authors collect data through the MIUI community (the online community network of Xiaomi, a high‐tech company). The findings reveal a close link between the NPD performance of firms and the motivations for consumer involvement. The findings also have implications for practitioners concerned with the management of consumer resources.
Toll‐like receptor 3 stimulation triggers metabolic reprogramming in pharyngeal cancer cell line through Myc, MAPK, and HIF
Authors: Matijevic Glavan Tanja , Cipak Gasparovic Ana , Vérillaud Benjamin , Busson Pierre , Pavelic Jasminka
Published: November 2016

Toll‐like receptor 3 (TLR3) has a dual role in cancer; its activation can trigger apoptosis as well as stimulate cancer cell survival, proliferation, and progression. We have shown here that TLR3 activation can induce metabolic reprogramming in a pharyngeal cancer cell line, leading to increased aerobic glycolysis, cell migration, elevated levels of reactive oxidative species (ROS), and decreased anti‐oxidative response. Key proteins in these signaling pathways are heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), pyruvate kinase M2 (PKM2), and CD44 variants, which were over‐expressed after TLR3 stimulation. TLR3 activation also induced upregulation of different genes involved in cancer progression (VEGF, MMP9, uPAR) and enzymes involved in glycolytic pathway. Most of the observed effects were Myc‐dependent; however, some of them were also connected with MAPK and HIF signaling pathways. Since TLR3 agonists are being investigated as potential novel cancer therapy adjuvants and apoptosis inducers, alone or in combination with other therapeutic options, data presented here suggest extreme caution before their introduction into clinical practice. The fact that TLR3 ligands [poly(I:C) and poly(A:U)] can also aid cancer survival and progression, through induction of metabolic reprogramming, emphasizes the need to investigate this particular topic. Our data suggest that the combination of TLR3 ligands with Myc or MAPK inhibitors may be a way to neutralize their undesirable effects while enhancing their anti‐tumor effect. © 2016 Wiley Periodicals, Inc.
Genetic variants in the promoter region of the calcium‐sensing receptor gene are associated with its down‐regulation in neuroblastic tumors
Authors: Masvidal Laia , Iniesta Raquel , García Marta , Casalà Carla , Lavarino Cinzia , Mora Jaume , de Torres Carmen
Published: November 2016

We have previously reported that the calcium‐sensing receptor (CaSR) is expressed in benign, differentiated neuroblastic tumors, and epigenetically silenced in undifferentiated, malignant cases. Furthermore, cinacalcet, an allosteric activator of the CaSR, reduces neuroblastoma tumor growth in preclinical models. However, to identify patients that might benefit from this treatment, a complete understanding of mechanisms governing CaSR expression in these tumors would be required. We have now analyzed two polymorphisms in the promoter region of theCASRgene (rs7652589 and rs1501899) by allelic discrimination in neuroblastoma patients and cell lines. Association of genotypes and haplotypes withCaSRmRNA levels andCASRpromoter P2 methylation status was determined. Data presented show that minor alleles rs7652589 and rs1501899, present either in homo‐ or heterozygosis, were correlated with reducedCaSRmRNA levels in matching primary tumors and this association was independent ofCASRpromoter P2 hypermethylation. Haplotype AA was independently associated with reducedCaSRexpression after adjusting by promoter P2 methylation status. These polymorphisms were identified in some ganglioneuromas in which CaSR expression is low despite exhibiting a high degree of differentiation. Furthermore, homozygous variants rs7652589 and rs1501899 were detected in SH‐SY5Y cells, which are devoid ofCaSRexpression in the absence of hypermethylation ofCASRpromoter P2. In summary, minor alleles rs7652589 and rs1501899 are associated with reduced CaSR expression in neuroblastic tumors and neuroblastoma cell lines in which theCASRgene promoter P2 is not hypermethylated. Therefore, they potentially represent an additional mechanism ofCASRtranscriptional regulation in this group of developmental malignancies. © 2016 Wiley Periodicals, Inc.
TGFβ signaling confers sorafenib resistance via induction of multiple RTKs in hepatocellular carcinoma cells
Authors: Ungerleider Nathan , Han Chang , Zhang Jinqiang , Yao Lu , Wu Tong
Published: November 2016

Transforming growth factor β (TGFβ) is a multifunctional cytokine which is importantly implicated in hepatocarcinogenesis. The current study provides novel evidence that TGFβ upregulates the expression of multiple receptor tyrosine kinases (RTKs), including IGF1R, EGFR, PDGFβR, and FGFR1 in human hepatocellular carcinoma (HCC) cells. This, in turn, sensitized HCC cells to individual cognate RTK ligands, leading to cell survival. Our data showed that the TGFβ‐mediated increase in growth factor sensitivity led to evasion of apoptosis induced by the mutikinase inhibitor, sorafenib. Conversely, we observed that inhibition of the TGFβ signaling pathway by LY2157299, a TGFβRI kinase inhibitor, enhanced sorafenib‐induced apoptosis, in vitro. Our findings disclose an important interplay between TGFβ and RTK signaling pathways, which is critical for hepatocellular cancer cell survival and resistance to therapy. © 2016 Wiley Periodicals, Inc.
A model‐based process to improve robustness in Multicriteria Decision Aiding interventions
Authors: Norese Maria Franca
Published: November 2016

A model‐based process is a methodological approach that facilitates interventions in new and ill or not structured problem situations. It is oriented towards improving the robustness of the intervention and its results in an incremental definition of both the problem formulation and the model, in order to reduce the uncertainty that is not only associated with the model parameters but also with the model structure, and sometimes also with the problem formulation. The nature and results of this approach, which consider the interaction between an analyst and the actors of the decision system as the decision aiding core, are proposed in relation to some actual interventions.
Alterations of the circadian system in Parkinson's disease patients
Authors: Fifel Karim
Published: November 2016

Alterations of circadian rhythms are among the most debilitating non‐motor symptoms in Parkinson's Disease (PD). Although a growing awareness towards these symptoms has occurred during the last decade, their underlying neuropathophysiology remains poorly understood and consequently no effective therapeutic strategies are available to alleviate these problems. Recent studies have investigated multiple circadian rhythms at different stages of PD. The advances made have allowed an accurate evaluation of the affected underlying pathways and mechanisms. Here I dissect, over disease progression, the relative causal contribution to health impairments in PD patients of dysfunctions in the different components of the neural network governing circadian rhythms. A deeper understanding of these mechanisms will provide not only a greater understanding of disease neuropathology, but also hold the promise for effective therapies. © 2016 International Parkinson and Movement Disorder Society
Arginase Inhibitors: A Rational Approach Over One Century
Authors: Pudlo Marc , Demougeot Céline , Girard‐Thernier Corine
Published: November 2016

Arginase (EC 3.5.3.1) is the bimanganese enzyme that converts L‐arginine into ornithine and urea. This enzyme was discovered more than a century ago and early α‐amino acids were identified as weak inhibitors. It was only during the 90s, after nitric oxide (NO) was reported as one of the most important biological mediators and when tight interrelation of arginase and NO synthase was found, that the development of arginase inhibitors was accelerated. The regulation of arginase activity by the N‐hydroxy‐L‐arginine (3, NOHA) intermediate of the NO synthesis was the starting point of the N‐hydroxy‐nor‐arginine (21, nor‐NOHA) that proved to be the first micromolar inhibitor. The previously known manganese and arginase binding by borate inspired the 2(S)‐amino‐6‐boronohexanoic acid (39, ABH) and S‐(2‐boronoethyl)‐L‐cysteine (40, BEC) now both considered as reference compounds in arginase inhibition. The high‐resolution crystal structure of arginase and molecular modeling has rendered possible the recent design of (53) the strongest α,α‐disubstituted derivatives of ABH. Simultaneously, traditional medicinal plants have contributed as a source of molecular diversity to the discovery of arginase inhibitors. This rational, step‐by‐step approach serves as guide in the present review where emphasis is placed on structure activity relationships.

Highlights

exhaustive review on arginase inhibitors

highlight is made on rational approach to conception and structure activity relationships

evaluation model is systematically mentioned with results.
Stability of a transmission problem for Kirchhoff‐type wave equations with memory on the boundary
Authors: Park Sun‐Hye
Published: November 2016

In this paper, we investigate the influence of boundary dissipation on the decay property of solutions for a transmission problem of Kirchhoff‐type wave equations with a memory condition on one part of the boundary. Without the condition u0 = 0 on Γ0, we establish a general decay of energy depending on the behavior of relaxation function by introducing suitable energy and Lyapunov functionals. This result allows a wider class of relaxation functions. Copyright © 2016 John Wiley & Sons, Ltd.
Eigenvalues of regular fourth‐order Sturm–Liouville problems with transmission conditions
Authors: Li Kun , Sun Jiong , Hao Xiaoling
Published: November 2016

In this paper, a class of fourth‐order Sturm‐Liouville problems with transmission conditions is considered. The eigenvalues depend not only continuously but also smoothly on the problem. An expression for the derivative of the eigenvalues with respect to a given parameter: an endpoint, a boundary condition, a transmission condition, a coefficient, or the weight function, is found. Copyright © 2016 John Wiley & Sons, Ltd.
Small perturbations of an interface for elastostatic problems
Authors: Lagha Jihene , Triki Faouzi , Zribi Habib
Published: November 2016

We consider the Lamé system for an elastic medium consisting of an inclusion embedded in a homogeneous background medium. Based on the field expansion method and layer potential techniques, we rigorously derived the asymptotic expansion of the perturbed displacement field because of small perturbations in the interface of the inclusion. We extend these techniques to determine a relationship between traction‐displacement measurements and the shape of the object and derive an asymptotic expansion for the perturbation in the elastic moment tensors because of the presence of small changes in the interface of the inclusion. Copyright © 2016 John Wiley & Sons, Ltd.
α‐trideuteromethyl[15N]glutamine: A long‐lived hyperpolarized perfusion marker
Authors: Durst Markus , Chiavazza Enrico , Haase Axel , Aime Silvio , Schwaiger Markus , Schulte Rolf F.
Published: November 2016

Purpose

We characterized the performance of a novel hyperpolarized perfusion marker, α‐trideuteromethyl[15N]glutamine, for direct comparison with a 13C‐based hyperpolarized perfusion marker, [13C, 15N2]urea.

Methods

A hardware platform and pulse sequence for in vivo 15N experiments were established. Hyperpolarized solutions of α‐trideuteromethyl[15N]glutamine and [13C, 15N2]urea were injected into healthy male Lewis rats. Kidney slice images were acquired using a single‐shot spiral readout. Both compounds were compared to determine in vivo signal lifetime and tracer distribution. Mass spectrometry was performed to evaluate excretion of the compound.

Results

Compared with 13C‐labeled urea, a significantly increased signal lifetime was observed. While the urea signal was gone after 90 s, decay of the glutamine compound was sufficiently slow to obtain a quantifiable signal, even after 5 min. The glutamine derivative showed strong localization in the kidneys with little background signal. Effective T1 of α‐trideuteromethyl[15N]glutamine was approximately eight‐fold higher than that of urea. Mass spectrometry results confirmed rapid excretion within the time scale of the measurement.

Conclusion

Hyperpolarized α‐trideuteromethyl[15N]glutamine is a highly promising candidate for renal studies because of its long signal lifetime, strong localization and rapid excretion. Magn Reson Med 76:1900–1904, 2016. © 2016 International Society for Magnetic Resonance in Medicine
Muscle fiber type proportion and size is not altered in mcardle disease
Authors: Henning Franclo , Cunninghame Carol Anne , Martín Miguel Angel , Rubio Juan Carlos , Arenas Joaquín , Lucia Alejandro , HernáNdez‐Laín Aurelio , Kohn Tertius Abraham
Published: November 2016

Introduction

McArdle disease is a metabolic myopathy that presents with exercise intolerance and episodic rhabdomyolysis. Excessive muscle recruitment has also been shown to be present during strenuous exercise, suggesting decreased power output. These findings could potentially be explained by either impaired contractility, decreased fiber size, or altered fiber type proportion. However, there is a paucity of data on the morphological features seen on muscle histology.

Methods

We examined muscle biopsies of patients with McArdle disease from a Spanish cohort and compared the findings with healthy controls.

Results

We found no significant difference in the fiber type proportion or mean fiber size between McArdle patients and controls in the biceps brachii or vastus lateralis muscles.

Conclusions

No alterations in muscle fiber type proportion or size were found on muscle histology of patients with McArdle disease. Future research should focus on assessment of muscle fiber contractility to investigate the functional impairment. Muscle Nerve 55: 916–918, 2017
Prenatal myelomeningocele repair: Do bladders better?
Authors: Horst Maya , Mazzone Luca , Schraner Thomas , Bodmer Christine , Möhrlen Ueli , Meuli Martin , Gobet Rita
Published: November 2016

Aims

Prenatal myelomeningocele (MMC) repair has been proven to significantly reduce the need for hydrocephalus shunting and improve lower‐extremity motor outcomes. The aim of this study was to evaluate the effect of prenatal MMC repair on the urological outcome.

Methods

All patients who underwent fetal MMC repair at our institution are followed prospectively. Assessments include medical history, renal and bladder ultrasound, voiding cystourethrogram and urodynamic study, need for clean intermittent catheterization (CIC) and anticholinergics, and the occurrence of urinary tract infections (UTI).

Results

Of the 30 patients who underwent prenatal MMC closure from December 2010 to December 2015, eight patients with a postnatal follow‐up of at least 2 years were included in this study and compared with eight patients after postnatal MMC repair. The level of the bony spinal defect was similar in both groups. Urological evaluation at 2 years revealed normal bladder function in 50% after prenatal repair. Neurogenic bladder dysfunction requiring CIC and anticholinergic therapy was seen in 50% in the prenatal and in 100% in the postnatal group. Significant bladder wall thickening was found in 37.5% and 87.5%, respectively. Febrile UTIs occurred in 37.5% in the prenatal and 62.5% in the postnatal group during the observation period.

Conclusions

Our data suggest a positive effect of prenatal MMC closure on lower urinary tract function. The long‐term significance of these results remains unclear. Therefore, continued close monitoring of renal and bladder function are mandatory.