bluuebunny/crossref_metadata_2025 huggingface dataset:
O monitoramento comportamental como medida de exposição ocupacional e ambiental de agentes tóxicos
Authors: Bravin André Amaral , Souza Lucas Codina de , Eckerman David Alan , Rohlman Diane Schertler
Published: August 2022

Resumo Introdução: o comportamento, como uma função biológica do organismo, pode ser tomado como objeto de estudo da neuropsicologia, já que parte do propósito dessa ciência é identificar, caracterizar e compreender as variáveis que o afetam, como a exposição crônica a agentes tóxicos. Objetivo: sustentar a ideia de que o comportamento humano pode ser utilizado como medida de identificação e avaliação da exposição ambiental e ocupacional de toxicantes. Métodos: este ensaio se apoia em revisão assistemática de literatura da área de toxicologia comportamental. Resultados: buscou-se caracterizar a abordagem comportamental como uma alternativa de mensuração em estudos epidemiológicos e apresentar algumas medidas e técnicas de avaliação neurocomportamentais. Discute-se a importância da padronização das baterias neurocomportamentais e suas limitações, além de exemplificar o seu uso potencial na triagem toxicológica com solventes (hexano). Conclusão: argumentou-se em favor da importância da toxicologia comportamental como área de interesse da saúde ocupacional, assim como da utilização de avaliações comportamentais na detecção precoce e prevenção de agravos à saúde dos trabalhadores, de modo a oferecer subsídios para o desenvolvimento de processos de produção mais seguros.
A TOTALIDADE NEOLIBERAL-FUJIMORISTA: ESTIGMATIZAÇÃO E COLONIALIDADE NO PERU CONTEMPORÂNEO
Authors: Villalba Fernando Velásquez
Published: August 2022

Resumo Este artigo explora a relação entre violência, racismo e estigmatização no contexto do conflito armado interno peruano (1980-2000) e como essa relação afeta tanto os processos de memória no Peru, iniciados após o colapso do governo de Alberto Fujimori (2000), quanto as dimensões de continuidade das práticas coloniais expressas no perfil étnico do “outro”, a fim de transformá-lo em um inimigo social e político. A partir de estudos de memória e da história político-cultural, este artigo traça uma ligação entre as batalhas de memória e a mobilização social, propondo que essa ligação seja mediada pelo que no Peru é conhecido como terruqueo, ou seja, a construção artificial, racista e conveniente de um inimigo sociopolítico para deslegitimar formas de protesto social que contradizem o que, neste artigo, eu chamo de totalidade fujimorista: uma combinação de práticas totalitárias discursivas e enclaves politicamente autoritários, impulsionados por um modelo de desenvolvimento neoliberal e extrativista.
O idadismo no contexto do trabalho da Estratégia Saúde da Família: projeção de saberes ao tetragrama dialógico de Morin
Authors: Melo Ricardo Henrique Vieira de , Amorim Karla Patrícia Cardoso
Published: August 2022

Trata-se de um estudo teórico com o objetivo de aproximar aportes sobre o idadismo ao tetragrama dialógico de interações, proposto por Morin, no contexto do trabalho na Estratégia Saúde da Família e na Atenção Primária à Saúde. Para isso, foi realizada uma projeção simbólica de saberes sobre o etarismo organizada em quatro atos: ordem, dispersão, interação e religação. Conclui-se que esse exercício teórico pode ser transmutado para o cotidiano de trabalho na Saúde, no qual a compreensão da existência do tetragrama dialógico, atuando simultaneamente na vida de forma antagônica, concorrente e complementar, pode incitar um pensar crítico, criativo e complexo em prol de saberes e de práticas frente à complexidade do idadismo.
SOCIODRAMA EM CENA: A SAÚDE DOS RESIDENTES DE EQUIPE MULTIDISCIPLINAR
Authors: Barroso Niveamara Sidrac Lima , Alves Danielle Fernandes Vasconcelos
Published: August 2022

RESUMO Este artigo apresenta o uso do sociodrama como ferramenta no processo de formação de residentes em um hospital-ensino na cidade de Fortaleza, no que tange ao desempenho dos seus papéis de profissionais de saúde-estudantes atuando em equipes multiprofissionais numa rede de assistência hospitalar. Foram utilizadas sessões de sociodrama num intervalo de 15 dias entre elas. As análises das sessões realizadas e os relatos dos residentes evidenciaram o potencial do sociodrama como importante estratégia de intervenção de políticas públicas na medida em que contribuiu para cuidar da saúde do trabalhador de saúde e empoderou o grupo multiprofissional, promovendo fortalecimento dos vínculos e melhorando o desempenho de seus papéis profissionais na instituição. Esse artigo contribui para a divulgação do Psicodrama no Brasil.
DECOLONIZANDO O CONCEITO DE RECONHECIMENTO (EU-TU)
Authors: Vomero Laura de Souza Zingra
Published: August 2022

RESUMO O presente estudo é uma análise crítica acerca da aplicação teórica e prática do psicodrama. Propõe novas elaborações ao repensar conceitos e práxis da socionomia que contribuam com o seu tema principal: a inclusão. Por isso, é apresentada a urgência em desconstruir o homem universal — cisgênero, heterossexual, branco, cristão — no movimento psicodramático para que todas as pessoas possam passar por um reconhecimento do eu e do tu de modo mais verdadeiro, sem as armadilhas impostas por uma branquitude colonizadora, produtora e reprodutora de uma realidade de expectativas e ideais que favorece a manutenção de seus privilégios.
QUAIS SÃO AS POLÍTICAS E PRÁTICAS EM RECURSOS HUMANOS MAIS UTILIZADAS PELAS EMPRESAS COM MELHORES ÍNDICES ESG NO BRASIL?
Authors: Schleich Melissa Velasco
Published: August 2022

Resumo Pesquisas sobre a interação entre a gestão de pessoas e a sustentabilidade no Brasil são recentes, embora o movimento seja crescente. O presente estudo teve como objetivo investigar quais políticas e práticas em recursos humanos são mais comumente utilizadas por empresas brasileiras que se destacam em ESG (environmental, social and governance) e averiguar, entre essas políticas e práticas, quais contribuem mais fortemente para ratings em ESG. Para tanto, analisaram-se as 106 empresas brasileiras disponíveis no sistema Refinitiv ESG scores no período entre 2015 e 2019, no que tange às métricas sob a categoria de colaboradores (dimensão social). Os resultados demonstraram que grande parte das empresas nos níveis mais altos de ESG já incorporou diversas políticas relacionadas a colaboradores; no entanto, a prática ainda se encontra aquém das políticas. Adicionalmente, identificaram-se métricas que podem representar uma oportunidade de melhoria, como a aplicação de práticas junto à cadeia de suprimentos, existência de equipe focada em saúde e segurança e implementação de políticas voltadas a treinamento e desenvolvimento, diversidade e oportunidade.
Morphophysiological responses of Setaria viridis to cold stress
Authors: Carvalho Calil Gibran Iraiore , Santos Mariana de Lima , Vieira Letícia Rios , Lopes Amanda Moreira , Carmona Paula Andrea Osorio , Sousa Carlos Antonio Ferreira de , Souza Junior Manoel Teixeira
Published: August 2022

Abstract The objective of this work was to determine the suitability of Setaria viridis as a model plant in studies to validate candidate genes for cold tolerance by evaluating the response of two of its accessions to different durations of abrupt or gradual cold stress in the vegetative and reproductive stages. Plants of accessions A10.1 and Ast-1, cultivated at 25°C, were subjected to the following cold stress treatments: gradual reduction in temperature from 25 to 0°C, 5°C at a time, every 24 hours in a same chamber; or abrupt reduction in temperature, by transferring plants from a chamber at 25°C to another at 0°C. Plants were kept at 0°C for 3, 5, or 10 days, after which temperature was increased back again to 25°C; a control group remained at 25ºC. Low temperatures – reduced abruptly or gradually – caused a decrease in the gas exchange rates and shoot and root biomass of the plants, besides damage to their photochemical apparatus; the longer the cold lasted, the more pronounced the effect was. Regardless of stress duration, plants recovered and completed their life cycle. The studied accessions are tolerant to cold and, therefore, are not suitable as a model plant in studies to validate candidate genes for cold tolerance.
Influenza A virus circulation in pig nurseries in the state of Santa Catarina, Brazil
Authors: Ferreira Maicom Vinícios , Gava Danielle , Schaefer Rejane , Pierozan Ricardo Luis , Zanella Janice Reis Ciacci
Published: August 2022

Abstract The objective of this work was to evaluate the infection caused by influenza A virus (IAV) subtypes and its incidence in pig nurseries in the state of Santa Catarina, Brazil. A total of 423 nursery pigs were sampled in 11 farms, and IAV circulation, viral RNA, and antibodies were identified. Reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) was used to detect viral RNA in nasal swab samples (70.2%) and to subtype 33 viruses, of which 18 (54.5%) from six nurseries were the H3N2 virus, 6 (18.1%) from two nurseries were H1N1pdm, and 9 (27.2%) from three nurseries could not be subtyped. The enzyme-linked immunosorbent assay (ELISA) detected the presence of IAV antibodies (68%), which was confirmed by the hemagglutination inhibition test, revealing a higher prevalence of antibodies for the H3N2 virus (38.0%), followed by H1N1pdm (23.8%) and H1N2 (3.23%). The obtained data showed that 10.3% of the swine reacted to at least two viral antigens. There is a high prevalence of influenza A virus infection in all 11 piglets nurseries sampled by viral RNA and antibody detection. H3N2 and H1N1pdm, in this order, are the most detected viral subtypes in the 11 sampled nurseries.
The effect of paste composition, aggregate mineralogy and temperature on the pore solution composition and the extent of ASR expansion
Authors: Bagheri Mahsa , Lothenbach Barbara , Scrivener Karen
Published: August 2022

The reaction kinetics of the alkali silica reaction depends on the composition of the pore solution. The evolution of the pore solution composition in different cement pastes and concretes was studied. Pastes containing silica fume or metakaolin had the lowest amount of alkalis in the pore solution. In addition, metakaolin increased the aluminium concentrations. The lowest expansion was measured for the concretes made of blended cement pastes with low alkali and hydroxide content in their pore solution, for the duration of the present study, no additional aluminium effect was observed due to the already low pH. Addition of 400 mM of Li slowed down expansion rate of concrete prisms at 40 and 60 °C, however, similar expansion was observed for samples with and without Li at 60 °C after 1 year. Temperature, alkali concentration and pH of pore solution all have a major effect on ASR expansion.
Diversität. Literaturbericht zu einem Gebot der Stunde
Authors: Favell Adrian
Published: August 2022

Gäbe Raymond Williams sein epochales Handbuch

Keywords: A Vocabulary of Culture and Society (1976) heute in einer überarbeiteten Auflage heraus, würde er zweifellos den Eintrag «Diversität» aufnehmen. Während das Konzept der Biodiversität seine eigene Geschichte in den Naturwissenschaften hat, handelt es sich beim Begriff der sozialen Diversität um einen Ausdruck, der sich in der neoliberalen Globalisierungseuphorie in den 1990er Jahren durchgesetzt hat. Nach 1989 reihte sich Diversität in Vorstellungen von offenen Grenzen und Freizügigkeit ein, von Weltbürgertum und Multikulturalismus, von Hybridität und Identitätspolitik, von Mobilität und Transnationalismus. Diversität beschrieb die Vielfältigkeit der globalen Welt – oder zumindest des trans-atlantischen Westens – und betonte zugleich die moralische Vorrangstellung des Individuums, die Freiheit, anders zu sein, zu handeln oder zu denken. In Anbetracht der Tatsache, dass das Ende des Kalten Krieges erst einmal den alternativlosen Sieg einer monokulturellen politischen Ökonomie markierte, entbehrt das neue Gebot der Vielfältigkeit nicht einer gewissen Ironie.
Und es hat Zoom gemacht
Authors: Daub Adrian
Published: August 2022

Die Zukunft der Sitzung hat ihren Sitz am Almaden Blvd in San José und gibt keine Interviews. Wie kaum ein anderes Unternehmen hat die Firma Zoom Video Communications die Lebens- und die Arbeitswelt der Pandemiejahre umgekrempelt. Vor dem ersten Lockdown im März 2020 galt Zoom als altbacken. Visionäre,

wispern heute immer noch viele im Silicon Valley, seien die nicht. Aber vielleicht war gerade diese Behutsamkeit das Erfolgsrezept. Zoom hat unsere Sitzungswelt eben nicht kühn ganz neu designt, sondern das Setting dieser besonderen sozialen Form recht konservativ wie ein Möbel in die digitale Welt versetzt. Wie ja viele der anderen virtuellen Meeting-Module auch. Seit die Welt auf das Silicon Valley schaut, blickt sie auch auf dessen Sitzungskultur. Gretchen M. Spreitzer und Robert E. Quinn haben 2001 in ihrem Buch A Company of Leaders: Five Disciplines for Unleashing the Power in Your Workforce versucht zu

zeigen, wie «steile Hierarchien den Informationsfluss begrenzen» und «Entscheidungen verlangsamen».
Sitzen für die Demokratie. Die Plenarsitzung zwischen Debatte und Staffage
Authors: Schönberger Christoph
Published: August 2022

Alles scheint Routine zu sein. In regelmäßigen Abständen treten Parlamente zu Sitzungen zusammen, debattieren, beschließen Gesetze und verabschieden Beschlüsse. Als anthropologische Universalie treten gerade auch in den Plenarsälen die typischen Begleiterscheinungen aller Sitzungen auf: Wichtigtuerei, Langeweile, Vertagung. Bei näherem Hinsehen ist indes nichts davon selbstverständlich. Das schläfrige Publikum wird daran kurz erinnert, wenn sich plötzlich in der «Tagesschau» im Parlament von Honduras Abgeordnete balgen oder der Mob in Washington das Kapitol stürmt. Man mag sich auch das Urbild aller Militärputsche in Erinnerung rufen, den 18. Brumaire Napoleons im November 1799. General Joachim Murat gebot damals seinen Grenadieren, unter Trommelwirbeln den Rat der Fünfhundert aufzulösen, der in der Orangerie des Schlosses von Saint-Cloud westlich von Paris zusammengetreten war: «Foutez- moi tout ce monde-là dehors.» In diesen Momenten höchster Gefahr wird erst vollauf deutlich: Das eigentliche zivilisatorische Fundament der Demokratie ist die Sitzung.
Madde Tepki Kuramında Eşitleme Hatalarının Belirlenmesinde Kullanılan Delta ve Bootstrap Yöntemlerinin Çeşitli Değişkenlere Göre İncelenmesi*
Authors: SALMANER DOĞAN Rana , TAN Şeref
Published: August 2022

Alan yazın incelendiğinde test eşitleme ve faydaları ile ilgili birçok çalışmanın olduğu

görülmektedir. Ancak test eşitlemelerin faydalarının yanı sıra sınırlılıkları da vardır. Bunlardan

en bilineninin eşitleme hataları olduğu söylenebilir. Bu araştırmada TIMMS 2015 4. sınıf

matematik verisi kullanılarak bootstrap ve delta yöntemleri ile elde edilen Madde Tepki Kuramı

gözlenen ve gerçek puan eşitleme hatalarının farklı örneklem büyüklükleri ve ölçek dönüştürme

yöntemlerine göre incelenmesi amaçlanmıştır. Çalışma bir yöntemin daha kapsamlı ve farklı

değişkenler açısından incelenmesi yönüyle betimsel bir çalışmadır. Çalışmada birey yetenek

düzeylerinin yakın olması amaçlanarak, TIMMS başarı ölçeğinin orta noktasının (500) üstünde

ve altında yer alan ülkelerin (Avusturalya, Kanada, İtalya, İspanya, Hırvatistan, Slovak

Cumhuriyeti, Yeni Zelanda, Türkiye ve Gürcistan) verisi içinden rastgele olarak seçilmiş 500,

1000 ve 3000 kişilik örneklemler kullanılmıştır. TIMMS 2015 sınavında kullanılan 14 kitapçık

türünden hangisinin kullanılacağının belirlenmesi amacıyla Madde Tepki Kuramı varsayımları

incelenmiş ve kitapçıklar arasından model uyum indekslerinin hepsinin kabul edilebilir

düzeyde olduğu kitapçık çifti seçilmiştir. Yapılan analizler sonucunda genel olarak her iki yöntemde de

en düşük hata değerlerinin Stocking Lord yönteminde elde edildiği ve delta

yöntemiyle elde edilen hataların tüm örneklem büyüklüğünde bootstrap yönteminde elde edilen

hatalardan yüksek olduğu bulunmuştur.
Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker
Authors: Škara Lucija , Vodopić Tonći , Pezelj Ivan , Abramovic Irena , Vrhovec Borna , Vrtarić Alen , Sincic Nino , Tomas Davor , Bulimbašić Stela , Kuliš Tomislav , Ulamec Monika
Published: August 2022

High prevalence and mortality of prostate cancer (PCa) are well known global health issues. Novel biomarkers for better identifying patients with PCa are the subject of extensive research. Prostate specific antigen (PSA) shows low specificity in screening and diagnostics, leading to unnecessary biopsies and health costs. Eighty patients with PCa and benign prostate hyperplasia (BPH) were included in the study. We analyzed CAV1 gene expression and methylation in tissue. CAV1 cfDNA methylation from blood and seminal plasma was accessed as a potential PCa biomarker. Although methylation in blood plasma did not differ between PCa and BPH patients, methylation in seminal plasma showed better PCa biomarker performances than tPSA (AUC 0.63 vs. AUC 0.52). Discrimination of BPH and Gleason grade group 1 PCa patients from patients with higher Gleason grade groups revealed very good performance as well (AUC 0.72). CAV1 methylation is useful biomarker with potential for further seminal plasma cfDNA research, but its diagnostic accuracy should be improved, as well as general knowledge about cfDNA in seminal plasma.
Aplicación de pigmentos producidos por Streptomyces coelicolor en la síntesis de nanopartículas de plata con actividad antimicrobiana
Authors: Santos Ruiz Paola Andrea , Barrios Espinel Laura Nathaly
Published: August 2022

Streptomyces son bacterias Gram positivas que pertenecen al phylum Actinobacteria. Dentro de este género, la especie que más se destaca es Streptomyces coelicolor que codifica más de 20 grupos de genes involucrados en la biosíntesis de metabolitos secundarios bioactivos como antibióticos, los cuales han sido relevantes en medicina y biotecnología. Esta revisión tiene como objetivo identificar el potencial que tienen los pigmentos producidos por S. coelicolor mediante la aplicación de la nanotecnología en la síntesis de nanopartículas de plata, como una alternativa en el tratamiento de infecciones causadas por microorganismos resistentes. Hallazgos obtenidos en diferentes trabajos, resaltan las propiedades de esta especie para producir metabolitos secundarios como compuestos antibacterianos,antifúngicos, antivirales, antitumorales y anti-hipertensivos. Además, este grupo de bacterias son ideales para la formación de nanopartículas de plata extracelular e intracelularmente, ya que les proporciona una adecuada estabilidad como también polidispersidad, demostrandouna amplia actividad bactericida contra microorganismos como Staphylococcus aureus, Proteus vulgaris, Escherichia coli, Shigella dysenteriae, Klebsiella pneumoniae y Salmonella typhi. De esta manera, surge un gran interés por estos nanomateriales con actividad antimicrobiana, como una alternativa terapéutica para el control de patógenos resistentes a los fármacos tradicionales y como nuevos biocidas seguros y beneficiososen el control de infecciones.
Habilidades cognitivas y crecimiento económico en Colombia. Un análisis departamental
Authors: Jiménez Ramírez Sergio Augusto , Reyes Camargo Silvia Juliana
Published: August 2022

Este artículo estima los efectos de las habilidades cognitivas en el crecimiento económico de 22 departamentos colombianos entre 2000 y 2019. Mediante la construcción de una base de datos con las variables clave de un modelo de crecimiento moderno, se estima la heterogeneidad de dichos efectos en razón de: a) Las diferentes áreas del conocimiento evaluadas en la prueba Saber 11, y b) Las diferentes agrupaciones de departamentos, basadas en las tasas de crecimiento del PIB por habitante y el tamaño de sus economías. Los resultados obtenidos sugieren que el capital humano medido por las habilidades cognitivas tiene gran efecto positivo sobre la tasa de crecimiento económico de los departamentos, mientras que los años de escolaridad muestran un efecto positivo en el ritmo de crecimiento económico, aunque de menor magnitud que el generado por las habilidades cognitivas. Asimismo, las habilidades en matemáticas, lenguaje y ciencias naturales presentan mayores efectos positivos sobre el crecimiento económico y los efectos positivos de las distintas clases de habilidades cognitivas sobre el crecimiento, en general, son mayores en departamentos con tasas más altas de crecimiento que en departamentos económicamente más grandes
Itinerarios en la construcción histórico-institucional de la archivística como disciplina y profesión en Colombia
Authors: Vallejo Sierra Ruth Elena , Pirela Morillo Johann
Published: August 2022

Este artículo se basó en un enfoque cualitativo con método de investigación documental y técnicas de análisis de información. El objetivo general fue analizar los itinerarios en la construcción histórico-institucional de la archivística como profesión y disciplina en Colombia, la cual dio sus primeros pasos para establecerse como un espacio fundamental de trabajo durante el Reino de Nueva Granada, en el que se notó un importante apogeo de organización de archivos en entidades públicas. En el siglo XIX, se comenzaron a identificar las primeras propuestas de formación técnica, realizada a partir de cursillos, cursos cortos y otras estrategias de formación similares. Durante la década del setenta del siglo XX, se comienzan a constituir los programas académicos en esta área en importantes instituciones de educación del país, como la Universidad de La Salle, la Pontificia Universidad Javeriana, la Universidad del Quindío, la Universidad de Antioquia, la Institución Universitaria INPAHU y, más recientemente, en la Universidad Distrital Francisco José de Caldas. Para concluir, se plantea que la institucionalización de la archivística, como profesión y disciplina en Colombia, ha seguido un interesante proceso que ha considerado aspectos de orden institucional de las prácticas de organización de archivos, la formación técnica, tecnológica y profesional y los procesos de agremiación, que aseguran la protección y valoración institucional del ejercicio de estos profesionales como agentes fundamentales, que garantizan a su vez el acceso a la información, la preservación y conservación del patrimonio documental del país, y la transparencia como un elemento vital del fortalecimiento de la democracia.
A Note on Procrustean Fittings of Noisy Configurations
Authors: Borg Ingwer , Mair Patrick
Published: August 2022

When comparing two or more multidimensional scaling (MDS) configurations, one usually first eliminates meaningless differences by Procrustean transformations. Such fittings lead to a number of unresolved issues such as the typical shrinkage of the fitted configuration relative to the target or how to interpret major similarity measures under various conditions of noise in the data. We here prove that the shrinkage ratio is equivalent to the correlation of the coordinates of the target and the fitted configuration. Thus, in real-life applications, the fitted configuration is always smaller than the target configuration. Both coefficients approach 0 as the noise level goes up. The congruence coefficient of the configurations' distances, in contrast, remains at a high level even in case of pure noise, falsely suggesting that the configurations are somewhat similar. This is important information for the user of Procrustean analyses.
Theoretical Foundations of Constitutional and Legal Research of State and Public Control in the Light of Current Trends in the Development of Public Administration
Authors: Spiridonov A. A.
Published: August 2022

The paper shows from the standpoint of constitutional and legal science that state control (supervision), municipal control, public control are inextricably linked with the functions of the state and form a part of the subject of constitutional law and an important element of modern Russian constitutionalism. With this in mind, control and supervisory activities have very strong theoretical and legal and constitutional grounds due to the special importance of such activities for the normal functioning of the state as such, the state and public system and to ensure the full implementation of the constitutional and legal status of the individual. The author highlights the following current trends in the development of public administration in our country that are of particular importance for the further improvement of control and supervisory activities: the orientation of public administration to citizens, their rights, needs, expectations and wishes; openness (transparency) of public administration; development of forms of interactive communications of public authorities and society; reduction of excessive administrative burden on subjects in respect of which control and supervisory activities are carried out; the widespread introduction of a risk-based approach within the framework of control and supervisory activities; increasing the role of public control as a significant form of feedback in the government-public dialogue, contributing to the improvement of public administration. It is important to conduct modern constitutional and legal studies of state control (supervision), municipal control and public control with mandatory consideration of the indicated trends and based on the relevant priorities, which will allow developing legal approaches, normative and practical proposals that ensure the client-centricity of public administration, its even greater openness and clarity for citizens and increasing the level of satisfaction of society with the results of activities of public authorities at all levels.
Forensic significance of X-ray data in the definition prescription of diaphyseal fractures: a case from expert practice
Authors: Li Yulia B. , Vishniakova Marina V. , Klevno Vladimir A.
Published: August 2022

BACKGROUND: Determining the prescription of fractures is important when conducting a forensic medical examination of victims, accused persons, etc. This allows the expert to immediately determine the causal relationship of the skeletal injury found in the sub-expert with the events described in the decision on the forensic medical examination, especially in cases when the conducted examination according to medical documents may be concealed or distorted of the incidental circumstances; thus the investigating authorities need to decide on the case and establish the truth. Often, medical documents, especially in cases of a single request for medical help, do not contain enough information about the clinical picture of the fracture, with limited or missing descriptions of the local status. In such cases, one of the most important sources of information for the expert is radiography data (radiographs in electronic form or on X-ray film and computed tomograms), which the study allows the expert to conclude the mechanism of injury and the prescription of fractures. The study of literary sources on this topic did not reveal the exact criteria for determining the prescription of fractures based on the study of the X-ray examination results in the forensic aspect.
CASE PRESENTATION: The description of a case from practice was provided. In our practice, a case with fractures that did not correspond to the events of the described incident in the resolution as found by the sub-expert, and these fractures were not regarded by the surgeon as old and unrelated to the specified circumstances of the case. The presented radiograph examination allowed the forensic medical expert to determine the time frame of the detected fractures and establish the absence of a causal relationship of this injury with the events specified in the resolution.
CONCLUSION: The analysis of this expert case allows us to conclude the importance of examining the radiography data by the forensic medical expert to determine the description of fractures.
SIGNIFICANCE FOR FORENSIC MEDICINE: The presented case from the practice demonstrates the need for a critical approach of the forensic expert, both to the presented medical data and the information contained in the materials of the preliminary examination or criminal case, as well as the importance of an independent study of the X-ray examination results of the subject.
Geostatistical Framework for Estimation of VS30 in Data-Scarce Regions
Authors: Gilder Charlotte E. L. , De Risi Raffaele , De Luca Flavia , Mohan Pokhrel Rama , Vardanega Paul J.
Published: August 2022

The time-averaged shear-wave velocity in the upper 30 m (VS30) is widely used as a proxy for site characterization in building codes. Regional estimations of VS30 often use either slope-based, terrain-based, or geological approaches as a proxy. This technique has proven useful at a number of locations globally, and slope-based estimates formed the basis of the original global VS30 model implemented by the U.S. Geological Survey. Geostatistical models involve the study of potentially spatially correlated parameters. Modeling challenges arise when parameters are scarce or uncertain, and traditional geostatistical workflows cannot be implemented in all settings. In this study, the benefits of the spatial extents of VS30 proxies are used to supplement local data to implement a methodology for improving estimates using a multi-Gaussian Bayesian updating framework. This methodology is presented in the context of a data-scarce region, specifically, the Kathmandu Valley in Nepal. Using geostatistical approaches typically used by the petroleum industry, this article develops a novel practice-oriented framework for VS30 estimation that can be adapted for use on a region-by-region basis. This framework provides an informed estimate and assessment of the uncertainties in which quantification of VS30 is required in geotechnical earthquake engineering applications.
How does brand identity inform and drive institutional marketing?
Authors:   , Guerra Ilaria , Yau Pamela
Published: August 2022

This in-depth case study on Alonzo King LINES Ballet explores the factors that contribute to an organization's brand identity over time and how that informs and drives its marketing strategy. A review of the literature on identity, brand, image, and institutional marketing serves as the backdrop of this study, providing definitions and connecting themes for use in the data collection. Through interviews with past and current staff, as well as an analysis of archival material, a full picture of the organization's brand and institutional marketing strategy is depicted. This study serves as an example in the field of dance management of how one organization shaped its brand and marketed it over its forty-year history.
Regulation of NuRD complex proteins by O-GlcNAc transferase in breast cancer cells
Authors:   , Sharp Ryan , Reginato Mauricio J
Published: August 2022

Women in their lifetime have a one in eight chance of being diagnosed with breast cancer and, in the U.S., breast cancer is the second leading cause of female deaths. Triple negative breast cancer (TNBC) is the most lethal type of breast cancer, and currently has no targeted treatment. O- GlcNAcylation, a post translational modification of nuclear and cytoplasmic proteins by O-GlcNAc transferase (OGT), is upregulated in breast cancer. OGT/ O-GlcNAcylation regulates stem cells and contributes to cancer hallmarks including cell survival and proliferation. Recently, our lab has shown that OGT regulates breast cancer stem-like phenotypes which is associated with cancer progression and resistance to chemotherapy. Using a proteomic approach, we identified 143 proteins elevated in TNBC cells following increased O-GlcNAcylation. Six of these proteins function in the Nucleosome Remodeling and Deacetylase (NuRD) Complex, which has been shown to be involved in embryonic stem cell (SC) self-renewal and implicated in tumorigenesis. Here, we validate that NuRD complex proteins GATAD2B, GATAD2A, MTA2, RBBP4 and HDAC2 are regulated by OGT. We show that pharmacologically increasing O-GlcNAc levels or overexpressing OGT in TNBC cells elevated NuRD protein levels. Conversely, targeting OGT genetically in breast cancer cells reduces expression of NuRD complex proteins. Importantly, we show that GATAD2B levels are enriched in mammosphere formation assays and that knockdown of GATAD2B in TNBC cells blocks mammosphere formation, suggesting a possible novel role for GATAD2B regulating breast cancer SC phenotypes. Lastly, we show that overexpression of GATAD2B in TNBC cells promotes selective resistance to chemotherapeutic agent paclitaxel, but not to doxorubicin in vitro. Thus, O-GlcNAc regulation of the NuRD complex and specifically GATAD2B may be a novel mechanism that regulates breast cancer stem cell phenotypes and chemoresistance in TNBC cells.
Study of correlation between preoperative high resolution computed tomography temporal bone and intraoperative surgical findings in 60 cases of unsafe chronic otitis media
Authors: Bhagat Sanjeev , Aggarwal Ankita , Pandav Richa , Wadhwa Shelja , Sharma Dinesh , Yadav Vishav
Published: August 2022

Background: Cholesteatoma is a serious health hazard which can give rise to alarming intracranial and extracranial complications as it can progressively enlarge and invade into neighbouring structures. Thus, early diagnosis and prompt management of a suspected cholesteatoma is necessary. High resolution computed tomography (HRCT) temporal bone scan clearly defines the extent and location of soft tissue density in middle ear with adjoining bony erosions. The aim of the study was to determine the role of HRCT temporal bone in early detection of cholesteatoma and finding the correlation between preoperative HRCT temporal bone and intraoperative surgical findings.

Methods: Total 60 cases with unsafe chronic otitis media (COM) attending ENT OPD of Rajindra hospital, Patiala were selected for this prospective study. All patients were scanned for HRCT temporal bone and preoperative radiological data was correlated with intraoperative surgical findings. The results were calculated and analysed statistically.

Results: This study demonstrated good correlation between preoperative temporal bone HRCT scans with intraoperative surgical findings, particularly in ossicular erosion (except stapes), LSC erosion, facial canal erosion, lateral cortical wall erosion and dural and sinus plate erosion.

Conclusions: HRCT temporal bone scan evidently demarcates the soft tissue density in middle ear and mastoid with adjacent bone erosions and it also provide details of anatomical variations. Hence HRCT temporal bone is valuable in diagnosing and guiding surgical management of unsafe COM making it prerequisite before any surgical manipulation.
The role of lateral and medial posterior tibial slope in anterior cruciate ligament injuries: a case-control study
Authors: Chacko Ankith , T. C. Ranjith , Babu Murukan , Toms Ajith , John Susan
Published: August 2022

Background: The anterior cruciate ligament (ACL) is one of the major stabilisers of the knee   and is the most frequently involved ligament in knee injuries and related functional instability. The objective of the study was to compare the lateral posterior tibial slope (LPTS) and medial posterior tibial slope (MPTS) among those with ACL injury and those with the intact ligament.

Methods: MRI of 65 (male-43, female-22) ACL injured and 65 (male-58, female-7) ACL intact knees were studied. Using RadiAnt DICOM viewer software, the slopes of both medial and LPTS s were measured. The statistical analysis was performed by IBM SPSS 25. Associations between various factors were assessed using the Chi square test for categorical variables and independent t test were done for quantitative variables. P<0.05 had been considered statistically significant.

Results: Among cases the mean LPTS was 10.230±3.930 and mean MPTS was 6.610±3.490. Among controls, mean LPTS was 8.460±3.630, mean MPTS was 5.510±2.910. Case had a statistically significant (p=0.009) steeper LPTS than control population. MPTS of cases were steeper than the control population with no statistical significance (p=0.055).

Conclusions: In this study, the LPTS was significantly increased among patients with ACL injury as compared with ligament-intact controls. LPTS measurements should be considered as a significant independent modifiable risk factor for ACL injury.
Old but effective during this lockdown period a modifies pin plaster technique to treat distal tibia fractures
Authors: Dhanraj Prashanth , Chitithoti Prathyush , Sunkoj Krishna Sai , Nithil Marupakala
Published: August 2022

There are various methods for treating fractures of the distal tibia. The purpose of this study was to introduce a modified technique of ‘pin in plaster’ in treating the distal 1/3rd tibia fractures. Fifteen patients with fractures of the distal tibia AO classification A1 and A2 were followed for one-year post-application of the cast. Patients were excluded if they had complicated fractures or grade III b fractures or crush injuries, with multiple injuries or any pathological fractures or with any nerve or vascular injuries. Range of movement and functional results were calculated periodically at the 3rd and 6th months. Three cases developed pin tract infection in the study, all of which were treated with oral antibiotics successful. The fibula was fixed with plating in selected cases There were no cases of nerve injuries and no cases of tendon injury. All the cases that were treated were successful and completely weight-bearing by the end of the 4th month. Our modified technique is simple quick and effective to restore anatomic congruity and maintain the reduction in fractures of the distal tibia.
Isolated trochlear shear fracture of the distal humerus: a case report
Authors: Mistarihi Saeb Mefleh , Azam Ehab Hamzeh , Shari Naser Fuad , Al Qasaimeh Motaz Mohammad Ali , Hawasheh Mohammad Jumah
Published: August 2022

Laugier was the first to describe an isolated humeral trochlea fracture in 1853. We report the case of a patient with an isolated fracture of the trochlea and discuss the underlying mechanisms and the clinical, radiological features of this pathology and surgical management of this rare fracture. The elbow arthrotomy was done via an anteromedial approach, with the interval through the flexor-pronator muscles medially and the brachialis muscle laterally. The trochlea was temporally fixed by two Kirschner wires, and the definitive fixation was obtained by two cannulated. Herbert screws from anterior to posterior. The elbow was immobilized and splinted in a flexed position (70 degrees) for two weeks to allow soft tissue healing and minimize pain. After cast removal, rehabilitation of elbow was established and actively assisted mobilization for three months. The isolated trochlea fracture is a rare injury and usually, it is associated with other injuries such as elbow dislocation. Few studies in the literature described such fracture and the anteromedial approach; most of these studies described the use of a direct medial approach to the elbow. Several fixation methods were described in the literature, including k-wires, AO compression screws, and headless compression screws. Isolated fracture of the trochlea is rare. The mechanisms causing this fracture are complex; the usual mechanism of isolated trochlear fractures is falling on the palm with the elbow extended and supinated. In our report, the patient disclosed that he felt directly on his flexed elbow. Trochlear fractures require open reduction and internal fixation to achieve anatomical reduction, with excision of the small osteochondral fragments that may be complicated by arthritic changes.
Evaluation of prognostic role of tumour budding in breast carcinoma and its correlation with known clinicopathological parameters
Authors: Gupta Vishakha , Patel Mandakini
Published: August 2022

Tumour budding (TB) consists of a small group of cells (upto 5) which have detached from the tumour bulk. TB has been studied in many malignancies including head and neck, colorectum, oesophagus, etc. However there are very few studies to determine its role in Breast cancer. This study was designed to study the role of tumour budding as a prognostic factor in Breast cancer.

To study the grade of TB in Invasive Breast Carcinoma and correlate it with known clinicopathological parameters to determine its usefulness as a prognostic factor.

In this retrospective observational study, 40 cases of modified radical mastectomy from July 2019 to December 2020 were evaluated for the tumour budding. Ethical clearance was not required as it was a secondary data collection study which did not relate to patient’s privacy, clinical examination or treatment. Significance and correlation was studied between the grade of TB and known clinicopathological parameters using Chi-square test.

Out of the 40 cases evaluated, 20 cases (50%) were of High grade TB (>/=10/10HPF), while 20 cases (50%) were of Low grade TB (<10/10HPF). Majority patients were of age group 40-60 years (60%), with primary carcinoma (52.5%) and invasive ductal type (72.5%). Higher TB was observed with Lymphnode positive cases (p=0.002), in higher TNM stage (p=0.006) and with lymphovascular invasion (p=0.000).

As higher grade tumour budding was associated with positive lymphnode status, higher tumour stage and presence of lymphovascular invasion, it can be considered as an indicator of poor prognosis in cases of breast carcinoma especially in resource poor institutes which are not equipped with sophisticated IHC and Molecular markers.
Systematic review on PDL-1 exression in human cancer
Authors: Moorthy Abishek Chakkaravarthi , Srivastava Vindu
Published: August 2022

Cancer is a leading cause of death worldwide with devastating mortality and morbidity. They present with myriad and exhaustively variable prodromes and symptoms or syndromic forms. Therapeutic modalities like chemotherapy and radiotherapy target replicative potential and excessive proliferative nature of neoplasms. Of the hallmarks of cancer, evasion of immune response to tumor proliferation is the target for another treatment option – immunotherapy, which has come into prominence over the last decade. Immunotherapy was developed when Dr. James Allison discovered a protein receptor on T cell surface, the cytotoxic T-lymphocyte antigen 4, which was later found to be involved in immunosuppression in cancer. The idea behind immunotherapy was conceived by Dr. Allison when experiments were conducted over decades and proteins were sought that could antagonize CTLA-4 and in theory could overturn the immunosuppressive nature of T cell behavior in a neoplastic background.

Immunotherapeutic strategies have evolved to include vaccines, oncolytic viruses, adoptive transfer of ex vivo activated T and natural killer cells, and administration of antibodies or recombinant proteins that stimulate T cells or block the immune checkpoint pathways, the so-called immune checkpoint inhibitors. Examples of immune check point targets include cytotoxic T lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD1;CD279) and programmed cell death protein 1 ligand (PDL-1;CD274).
O acompanhamento psicossocial de condenados por crimes sexuais sob a ótica da prevenção especial positiva
Authors: Suxberger Antonio Henrique Graciano , Jesus Ronny Alves de
Published: August 2022

A materialização da prevenção especial positiva do condenado criminalmente se apresenta como um desafio inconcluso às políticas penais. O artigo aborda a intervenção psicossocial com autores de crimes sexuais no contexto intrafamiliar durante a execução da pena. Ainda tratada como iniciativa incipiente na prática das penas no Brasil, a intervenção psicossocial constitui esforço para concretizar a finalidade de prevenção especial positiva da pena. Para avaliar a iniciativa, são, inicialmente, apresentadas as principais teorias justificacionistas da pena, que buscam legitimar o Direito Penal e seu papel de tutela objetiva de bens jurídicos, bem como as críticas históricas destinadas a cada uma delas. Após a descrição do projeto de intervenção e de sua metodologia, o artigo problematiza essa ação pública como medida de prevenção especial positiva. A investigação se vale de revisão da literatura específica sobre teorias das penas e experiências profissionais em projetos de intervenção psicossocial. Além disso, problematiza a justificativa teórica para a intervenção psicossocial cotejando-a com entrevista exploratória realizada com profissional do sistema de justiça responsável pelos encaminhamentos dos condenados ao programa.
A perda do direito à garantia securitária prevista pelo art. 766 do Código Civil à luz da teoria geral das invalidades do negócio jurídico
Authors: Souza Eduardo Nunes de
Published: August 2022

A perda do direito à garantia pelo segurado nos casos em que este omite informações relevantes para a delimitação do risco ou as presta de forma inexata, sanção prevista pelo art. 766 do Código Civil, embora tradicional no direito brasileiro, ainda causa controvérsia quanto à sua natureza jurídica. O presente estudo propõe uma análise da fattispecie à luz da teoria geral das invalidades contratuais, com vistas a se identificar o regime jurídico aplicável à assim denominada “perda do direito”, investigando os pontos de aproximação e distanciamento entre essa previsão e as características gerais da nulidade e da anulabilidade do negócio jurídico.
Promoção de trabalho decente e os contrassensos da Reforma Trabalhista: sindicato e diálogo social
Authors: Wenceslau Maurinice Evaristo , Schleich Ingrid Scudler
Published: August 2022

Trabalho decente é instrumento para a concretização da dignidade do trabalhador e da justiça social nas relações de trabalho. Diante de objetivos internacionais, o Brasil assumiu compromisso para efetivação de trabalho digno até o ano de 2030 e, para isto, implementou uma série de políticas públicas para o alcance das metas. Assim, instituiu-se o Programa “Promoção do Trabalho Decente e Economia Solidária”, que teve vigência nos anos de 2016 a 2019, com vistas à democratização das relações de trabalho, exercício de trabalho decente e fortalecimento do diálogo social. Entretanto, em uma economia fragilizada, são os direitos trabalhistas os primeiros a serem precarizados, fazendo-se inegável a importância da atuação sindical na representação dos trabalhadores no debate democrático. À vista disso, neste texto, extraído de pesquisa em andamento, objetivou-se avaliar a garantia de participação das entidades sindicais de forma adequada no diálogo social. Para tanto, analisou-se dados do Instituto Brasileiro de Geografia e Estatística e do Instituto de Pesquisa Econômica Aplicada acerca da sindicalização e indicadores do referido Programa, utilizando-se de pesquisas exploratória, bibliográfica e documental. Infere-se dos estudos que o ideal de participação sindical não é observado em consonância com os objetivos de trabalho decente e diálogo social almejados.
Democratização da Educação Superior na legislação: Educação à Distância e acessibilidade às pessoas com deficiência
Authors: Pedott Nathércia , Scott Jr Valmôr Scott
Published: August 2022

A educação é um direito assegurado na legislação brasileira às pessoas com deficiência. No entanto, sua materialização, por vezes, enfrenta diversos obstáculos. Este estudo tem como objetivo analisar como a legislação federal aborda a educação superior à distância e de que modo disciplina as condições de acessibilidade às pessoas com deficiência nesta modalidade de educação. Para tanto, metodologicamente, trata-se de uma pesquisa qualitativa, que utiliza como método a análise documental e, como técnica, a análise de conteúdo na legislação pertinente, com ênfase nos meios capazes de proporcionar a equiparação de oportunidades às pessoas com deficiência na educação superior. A educação superior à distância e as condições de acessibilidade às pessoas com deficiência estão disciplinadas, de modo incipiente, em poucas normas legais recentes. Contudo, é fundamental que a matéria possua positivação mais abrangente, pois a educação à distância é uma modalidade educacional que possibilita a acessibilidade das pessoas com deficiência na educação superior, de modo que possam exercer o direito social à educação, em busca de seu desenvolvimento intelectual e social.