bluuebunny/crossref_metadata_2025 huggingface dataset:
Cohabitation, Relationship Stability, Relationship Adjustment, and Children’s Mental Health Over 10 Years
Authors: Foran Heather M. , Mueller Janina , Schulz Wolfgang , Hahlweg Kurt
Published: February 2022

Understanding risk factors for relationship dissolution and poor relationship adjustment among couples has been an active area of research in relationship science. One risk factor, non-marital cohabitation, has shown to predict higher rates of relationship dissolution and relationship instability in some samples, but the associations among German parents with children over time are less clear. In this study, we examined the links between non-marital cohabitation and 10-year outcomes (relationship dissolution, relationship adjustment over time, and child internalizing and externalizing symptoms) in 220 German families with preschool-aged children at the initial assessment followed into adolescence. Families were assessed 7 times over the 10 years and retention at the 10-year follow-up was over 92%. After accounting for multiple testing, only mother’s report of better initial interparental communication predicted whether parents were likely to stay together over the course of the 10 years. Adolescents of parents who cohabited were at higher risk for externalizing symptoms 10 years later compared to children of married parents. In addition, although there were no differences between cohabiting couples and married couples at the initial assessment in relationship adjustment, cohabiting mothers who stayed with their partner over the 10 years showed significantly greater declines in relationship adjustment over the 10 years compared to married mothers. Findings indicate the need for further research that explores family structure and dynamics over time to inform refinement of prevention programs targeting relationships and children’s mental health.
Understanding East–West Cultural Differences on Perceived Compensation Fairness Among Executives: From a Neuroscience Perspective
Authors: Yu Fan , Zhao Ying , Yao Jianfeng , Farina Briamonte Massimiliano , Profita Sofia , Liu Yuhan
Published: February 2022

Cognitive neuroscience research has found that individuals from different cultures have different neural responses and emotional perceptions. Differences in executives’ perception of external pay gaps in different cultures can affect their work attitudes and behavior. In this study, we explore the direct relationship between executive compensation fairness and executive innovation motivation. We also investigate the moderating effects of Confucian culture and western culture between executive compensation fairness and executive innovation motivation. Data were collected from the Chinese listed firms from 2011 to 2019 and test the relationship using the fixed-effect panel regression models. The results demonstrate that executive compensation fairness positively influences the executive innovation motivation. This effect is more pronounced in Confucian culture regions, while Western culture weakens this effect. The findings of this study confirmed that executive compensation fairness, provide a cross-cultural comparison for compensation research, validate the findings of cultural neuroscience, and provide useful insights into the research of common prosperity. To improve the corporate compensation structure, it is necessary to consider the relative pay equity with firms in the same region and the influence of corporate culture.
Cooperation and Lateral Forces: Moving Beyond Bottom-Up and Top-Down Drivers of Animal Population Dynamics
Authors: Chen Ying-Yu , Rubenstein Dustin R. , Shen Sheng-Feng
Published: February 2022

Biologists have long known that animal population dynamics are regulated by a combination of bottom-up (resource availability) and top-down forces (predation). Yet, economists have argued that human population dynamics can also be influenced by intraspecific cooperation. Despite awareness of the role of interspecific cooperation (mutualism) in influencing resource availability and animal population dynamics, the role of intraspecific cooperation (sociality) under different environmental conditions has rarely been considered. Here we examine the role of what we call “lateral forces” that act within populations and interact with external top-down and bottom-up forces in influencing population dynamics using an individual-based model linking environmental quality, intraspecific cooperation, and population size. We find that the proportion of cooperators is higher when the environment is poor and population sizes are greatest under intermediate resources levels due to the contrasting effects of resource availability on behavior and population size. We also show that social populations are more resilient to environmental change than non-social ones because the benefits of intraspecific cooperation can outweigh the effects of constrained resource availability. Our study elucidates the complex relationship between environmental harshness, cooperation, and population dynamics, which is important for understanding the ecological consequences of cooperation.
What Research Has Been Conducted on Procrastination? Evidence From a Systematical Bibliometric Analysis
Authors: Yan Bo , Zhang Xiaomin
Published: February 2022

Procrastination is generally perceived as a common behavioral tendency, and there are a growing number of literatures to discuss this complex phenomenon. To elucidate the overall perspective and keep abreast of emerging trends in procrastination research, this article presents a bibliometric analysis that investigates the panorama of overviews and intellectual structures of related research on procrastination. Using the Web of Science Database, we collected 1,635 articles published between 1990 and 2020 with a topic search on “procrastination” and created diverse research maps using CiteSpace and VOS viewer. Bibliometric analysis in our research consists of category distribution, keyword co-occurrence networks, main cluster analysis, betweenness centrality analysis, burst detection analysis, and structure variation analysis. We find that most research has focused on students' samples and has discussed the definition, classification, antecedents, consequences and interventions to procrastination, whereas procrastination in diverse contexts and groups remains to be investigated. Regarding the antecedents and consequences, research has mainly been about the relationship between procrastination and personality differences, such as the five-factor model, temperament, character, emotional intelligence, and impulsivity, but functions of external factors such as task characteristics and environmental conditions to procrastination have drawn scant attention. To identify the nature and characteristics of this behavior, randomized controlled trials are usually adopted in designing empirical research. However, the predominant use of self-reported data collection and for a certain point in time rather than longitudinal designs has limited the validation of some conclusions. Notably, there have been novel findings through burst detection analysis and structure variation analysis. Certain research themes have gained extraordinary attention in a short time period, have evolved progressively during the time span from 1990 to 2020, and involve the antecedents of procrastination in a temporal context, theoretical perspectives, research methods, and typical images of procrastinators. And emerging research themes that have been investigated include bedtime procrastination, failure of social media self-control, and clinical interventions. To our knowledge, this is almost the first time to conduct systematically bibliometric analysis on the topic of procrastination and findings can provide an in-depth view of the patterns and trends in procrastination research.
School Belonging and Reading Literacy: A Multilevel Moderated Mediation Model
Authors: Tan Yuting , Fan Zhengcheng , Wei Xiaoman , Yang Tao
Published: February 2022

School belonging is of great significance to students' physical and mental health development, especially academic improvement. However, the mechanism of the influence of school belonging on student academic achievement should be further explored, especially reading performance. Based on ecological systems theory and self-determination theory, the present research constructs a multilevel design to examine a moderated mediation model in which school belonging as a level-1 predictor, mastery goal orientation as a level-1 mediator and school disciplinary climate as a level-2 moderator jointly impact reading literacy. Results of the study were based on the questionnaires from 11,364 (5,455 girls and 5,909 boys) 15-year-olds nested in 332 schools in mainland China that participated in PISA 2018. The cross-sectional analysis indicated that: (1) school belonging had a direct and positive effect on student reading literacy; (2) the relationship between school belonging and reading literacy was prominently mediated by mastery goal orientation; (3) both school disciplinary climate level and strength could negatively moderate the latter half path of “school belonging → mastery goal orientation → reading literacy.” Implications, limitations, and future research directions are discussed.
Absence of Behavioral Harm Following Non-efficacious Sexual Orientation Change Efforts: A Retrospective Study of United States Sexual Minority Adults, 2016–2018
Authors: Sullins D. Paul
Published: February 2022

Background

Do sexual minority persons who have undergone unsuccessful sexual orientation change efforts (SOCE) suffer subsequent psychological or social harm from the attempt? Previous studies have conflated present and past, even pre-SOCE, harm in addressing this question. This study attempts, for the first time, to isolate and examine the question of current psychosocial harm for former SOCE participants among sexual minorities in representative population data.

Method

Using nationally representative data (n = 1,518) across three cohorts of sexual minorities (centered in 1969, 1987, and 2003) in the United States (U.S.), persons exposed to SOCE were compared with the remainder not exposed to SOCE on two measures of internal distress—psychological distress (Kessler scale) and current mental health—and seven measures of behavioral harm: substance abuse (DUDIT); alcohol dependence (AUDIT-C); self-harm; suicide ideation; suicide planning; suicide intentions; and suicide attempts.

Results

The SOCE group was statistically indistinguishable from the non-SOCE group on any measure of harm. For behavioral harm, risk ratios were 0.97–1.02. Harm was equivalent for the two groups despite the SOCE group having experienced higher lifetime and current minority stress, greater childhood adversity, and lower socioeconomic status. Logistic regression models that adjusted for these differences suggest that SOCE exposure reduced the effect of minority stress and childhood adversity for suicide attempts, although this effect did not fully account for the equivalence between the SOCE and non-SOCE groups.

Conclusion

Despite higher exposure to factors predicting behavioral harm—minority stress, childhood adversity, and lower socioeconomic background—sexual minority persons who had undergone failed SOCE therapy did not suffer higher psychological or social harm. Concerns to restrict or ban SOCE due to elevated harm are unfounded. Further study is needed to clarify the reasons for the absence of harm from SOCE.
Differentiating Melancholic and Non-melancholic Major Depressive Disorder Using Fractional Amplitude of Low-Frequency Fluctuations
Authors: Zhang Yingying , Cui Xilong , Ou Yangpan , Liu Feng , Li Huabing , Chen Jindong , Zhao Jingping , Xie Guangrong , Guo Wenbin
Published: February 2022

Background

Melancholic major depressive disorder (MDD) is a network-based brain disorder. However, whether or not network-based changes can be applied to differentiate melancholic (MEL) from non-melancholic (NMEL) MDD remains unclear.

Methods

Thirty-one MEL patients, 28 NMEL patients, and 32 matched healthy controls (HCs) were scanned using resting-state functional magnetic resonance imaging. Patients were assessed by the Chinese version of Snaith–Hamilton Pleasure Scale (SHAPS-C) and Temporal Experience of Pleasure Scale (TEPS). Fractional amplitude of low-frequency fluctuations (fALFF) and correlation analysis were used to analyze the data.

Results

Compared with HCs, the MEL group had significantly higher fALFF values in the bilateral inferior frontal gyrus and right supplementary motor area (SMA) and significantly lower fALFF values in the right inferior occipital gyrus (IOG), right middle temporal gyrus (MTG)/left IOG, and bilateral superior occipital gyrus (SOG)/MTG. On the other hand, the NMEL group showed significantly higher fALFF values in the bilateral SMA and significantly lower fALFF values in the bilateral posterior cingulate cortex/precuneus relative to HCs. Compared with the NMEL group, the MEL group showed significantly lower fALFF values in the left anterior cingulate cortex (ACC). A correlation was found between the fALFF values of the right SMA and the SHAPS-C in the MEL group. In addition, correlations were observed between the fALFF values of the left ACC and the TEPS contextual consummatory and total scores in all patients.

Conclusion

Our study uncovered that MDD exhibited altered brain activity in extensive brain networks, including the default-mode network, frontal-striatal network, reward system, and frontal-limbic network. Decreased fALFF in the left ACC might be applied to differentiate the two subtypes of MDD.
Joint Hypermobility Links Neurodivergence to Dysautonomia and Pain
Authors: Csecs Jenny L. L. , Iodice Valeria , Rae Charlotte L. , Brooke Alice , Simmons Rebecca , Quadt Lisa , Savage Georgia K. , Dowell Nicholas G. , Prowse Fenella , Themelis Kristy , Mathias Christopher J. , Critchley Hugo D. , Eccles Jessica A.
Published: February 2022

Objectives

Autism, attention deficit hyperactivity disorder (ADHD), and tic disorder (Tourette syndrome; TS) are neurodevelopmental conditions that frequently co-occur and impact psychological, social, and emotional processes. Increased likelihood of chronic physical symptoms, including fatigue and pain, are also recognized. The expression of joint hypermobility, reflecting a constitutional variant in connective tissue, predicts susceptibility to psychological symptoms alongside recognized physical symptoms. Here, we tested for increased prevalence of joint hypermobility, autonomic dysfunction, and musculoskeletal symptoms in 109 adults with neurodevelopmental condition diagnoses.

Methods

Rates of generalized joint hypermobility (GJH, henceforth hypermobility) in adults with a formal diagnosis of neurodevelopmental conditions (henceforth neurodivergent group, n = 109) were compared to those in the general population in UK. Levels of orthostatic intolerance and musculoskeletal symptoms were compared to a separate comparison group (n = 57). Age specific cut-offs for GJH were possible to determine in the neurodivergent and comparison group only.

Results

The neurodivergent group manifested elevated prevalence of hypermobility (51%) compared to the general population rate of 20% and a comparison population (17.5%). Using a more stringent age specific cut-off, in the neurodivergent group this prevalence was 28.4%, more than double than the comparison group (12.5%). Odds ratio for presence of hypermobility in neurodivergent group, compared to the general population was 4.51 (95% CI 2.17–9.37), with greater odds in females than males. Using age specific cut-off, the odds ratio for GJH in neurodivergent group, compared to the comparison group, was 2.84 (95% CI 1.16–6.94). Neurodivergent participants reported significantly more symptoms of orthostatic intolerance and musculoskeletal skeletal pain than the comparison group. The number of hypermobile joints was found to mediate the relationship between neurodivergence and symptoms of both dysautonomia and pain.

Conclusions

In neurodivergent adults, there is a strong link between the expression of joint hypermobility, dysautonomia, and pain, more so than in the comparison group. Moreover, joint hypermobility mediates the link between neurodivergence and symptoms of dysautonomia and pain. Increased awareness and understanding of this association may enhance the management of core symptoms and allied difficulties in neurodivergent people, including co-occurring physical symptoms, and guide service delivery in the future.
Postpartum Depressive Symptoms and Their Selected Psychological Predictors in Breast-, Mixed and Formula-Feeding Mothers
Authors: Kossakowska Karolina , Bielawska-Batorowicz Eleonora
Published: February 2022

Background

Although breastfeeding is recommended by WHO and professionals as the most beneficial for newborn babies, many women find it challenging. Previous research yielded ambiguous results concerning the role of breastfeeding in the development of postpartum depression. The study aimed to identify the best predictors of depressive symptoms for each of these feeding method.

Methods

The participants were 151 women (mean age 29.4 yrs; SD = 4.5) who gave birth within the last 6 months and included 82 women classified as breastfeeding, 38 classified as mixed-feeding (breast and bottle), and 31 as formula-feeding. The study had a cross-sectional design using a web-based survey for data collection. The following measures were administered: The Edinburgh Postnatal Depression Scale; Sense of Stress Questionnaire; The Postpartum Bonding Questionnaire; Parenting Sense of Competence Scale; Infant Feeding Questionnaire.

Results

Women in study groups differed in stress, bonding difficulties, and beliefs related to feeding practices and infancy. There were no significant differences in the severity of depressive symptoms, but all mean EPDS scores were above 12. Maternal satisfaction, intrapsychic stress, and concerns about feeding on a schedule were the best predictors of EPDS scores for breastfeeding women. For mixed-feeding – emotional tension, concern about infant's hunger, overeating, and awareness of infant's hunger and satiety cues; while for the formula-feeding group, predictors included emotional tension, bonding difficulties, and such maternal feeding practices and beliefs as concern about undereating, awareness of infant's hunger and satiety cues, concerns about feeding on a schedule and social interaction with the infant during feeding.

Conclusion

Differences in predictors of postpartum depression for study groups suggest that breastfeeding itself may not be a risk for postpartum depression. However, the specificity of maternal experiences with the various types of feeding is related to difficulties promoting postpartum depression. Providing emotional and educational support appropriate for different types of feeding may be an essential protective factor for postnatal depression.
Association of Obesity, Sarcopenia, and Sarcopenic Obesity With Hypertension in Adults: A Cross-Sectional Study From Ravansar, Iran During 2014–2017
Authors: Pasdar Yahya , Darbandi Mitra , Rezaeian Shahab , Najafi Farid , Hamzeh Behrooz , Bagheri Amir
Published: February 2022

Background and Aims

Hypertension may lead to disability and death by increasing the risk of cardiovascular disease, kidney failure, and dementia. This study aimed to determine the association between obesity, sarcopenia and sarcopenic obesity, and hypertension in adults resident in Ravansar, a city in the west of Iran.

Methods

This cross-sectional study was conducted on 4,021 subjects from the baseline data of the Ravansar Non-Communicable Disease (RaNCD) cohort study, in the west region of Iran, from October 2014 up to February 2017. Body composition was categorized into obese, sarcopenia, sarcopenic obese, and normal based on measurements of muscle strength, skeletal muscle mass, and waist circumference. Univariate and multiple logistic regression models were used to examine the relationships, using the STATA 15 software.

Results

The mean age of the participant was 47.9 years (SD: 8.4), the body mass index (BMI) was 26.84 kg/m2 (SD: 4.44), and the prevalence of hypertension was 15.12%. The prevalence of obesity, sarcopenia, and sarcopenic obesity were 24.37, 22.01, and 6.91%, respectively. Body composition groups had significant differences in age, total calorie intake, BMI, skeletal muscle mass, and muscle strength (P-value ≤ 0.001). In crude model, the obese (OR = 2.64; 95% CI: 2.11–3.30), sarcopenic (OR = 2.45; 95% CI: 1.94–3.08), and sarcopenic obese (OR = 3.83; 95% CI: 2.81–5.22) groups had a higher odds of hypertension. However, in adjusted models, only the obese group had a higher likelihood of hypertension (OR = 2.18; 95% CI: 1.70–2.80).

Conclusion

This study showed that obesity was associated with hypertension, whereas sarcopenia and sarcopenic obesity had no significant relationship with hypertension.
Is Sedentary Behavior Associated With Executive Function in Children and Adolescents? A Systematic Review
Authors: Li Shiyuan , Guo Jinyang , Zheng Kefeng , Shi Mengyao , Huang Tao
Published: February 2022

Background

Prolonged time on sedentary behavior, especially screen-based sitting time, is associated with unfavorable health indicators in children and adolescents. However, the effects of sedentary behavior on cognitive function remain to be elucidated.

Objective

The purpose of this systematic review was to synthesize the evidence on the associations of sedentary behavior with executive function in children and adolescents.

Methods

Four electronic databases (i.e., PubMed, Web of Science, PsycINFO, and SPORTDiscus) were searched for studies examining the associations between sedentary behavior and executive function in children and adolescents. Study quality was assessed by the NIH Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies.

Results

A total of 1,151 records were initially identified through database searches and other searches. Twelve cross-sectional and four longitudinal studies met the inclusion criteria. Of the 16 studies, seven studies found significant negative associations between sedentary behavior and executive function, and two studies presented positive associations. Eight studies measured sedentary time using accelerometers and showed varied associations between objectively measured sedentary time and executive function. Nine studies measured screen-based sedentary behavior, of which five studies found negative associations of sedentary time with executive function.

Conclusion

The available evidence on the associations between sedentary behavior and executive function is not conclusive in children and adolescents. However, screen-based sedentary behavior may be negatively associated with executive function.
Developing and Evaluating a University Recommender System
Authors: Elahi Mehdi , Starke Alain , El Ioini Nabil , Lambrix Anna Alexander , Trattner Christoph
Published: February 2022

A challenge for many young adults is to find the right institution to follow higher education. Global university rankings are a commonly used, but inefficient tool, for they do not consider a person's preferences and needs. For example, some persons pursue prestige in their higher education, while others prefer proximity. This paper develops and evaluates a university recommender system, eliciting user preferences as ratings to build predictive models and to generate personalized university ranking lists. In Study 1, we performed offline evaluation on a rating dataset to determine which recommender approaches had the highest predictive value. In Study 2, we selected three algorithms to produce different university recommendation lists in our online tool, asking our users to compare and evaluate them in terms of different metrics (Accuracy, Diversity, Perceived Personalization, Satisfaction, and Novelty). We show that a SVD algorithm scores high on accuracy and perceived personalization, while a KNN algorithm scores better on novelty. We also report findings on preferred university features.
Thoracolumbar Rotation During Tai Chi Movements—A Biomechanical Analysis of the Entire Peking Style Routine
Authors: Wehner Christian , Wehner Carina , Schwameder Hermann , Schobersberger Wolfgang
Published: February 2022

The impact of spinal mobility and sagittal spinal shape on the development of balance impairment supports the hypothesis that enhancing spine flexibility results in an improvement in postural balance ability. Therefore, the aim of this study was to investigate whether the range of motion of thoracolumbar rotation during the movements of the Tai Chi Peking style routine is sufficient to improve thoracolumbar flexibility. Three-dimensional kinematic and kinetic data were collected from eight athletes of the German Wushu Federation, while performing all movements of the entire Peking style routine (1) in a competition version corresponding to national/international championships and (2) in a health sport version performed with shorter and higher stances (i.e. a smaller distance between the feet and thus less knee flexion). For each movement the total mean and standard deviation values for the total range of motion of thoracolumbar rotation was calculated. Statistical analysis was performed using the Wilcoxon signed-rank test for paired differences. Eight movements showed major differences (10.12–19.73°) between the two versions. For the remaining movements, only minor differences (0.7–9.56°) were observed. All movements performed on both sides showed no significant lateral differences. Most of the Tai Chi movements, regardless of the performed version, cover a range of motion of thoracolumbar rotation that has the potential to lead to an improvement of thoracolumbal spine flexibility with appropriate training. The most effective single movements (25.97–72.22°) are Brush Knee and Step Forward, Step Back and Repulse Monkey, Grasp the Sparrow‘s Tail, Wave Hand in the Clouds, and Fair Lady Weaves with Shuttle.
Comparison of PK/PD Targets and Cutoff Values for Danofloxacin Against Pasteurella multocida and Haemophilus parasuis in Piglets
Authors: Zhou Yu-Feng , Sun Zhen , Wang Rui-Ling , Li Jian-Guo , Niu Chao-Yan , Li Xian-An , Feng Yun-Yun , Sun Jian , Liu Ya-Hong , Liao Xiao-Ping
Published: February 2022

Danofloxacin is a synthetic fluoroquinolone with broad-spectrum activity developed for use in veterinary medicine. The aim of this study was to evaluate the pharmacokinetic/pharmacodynamic (PK/PD) targets, PK/PD cutoff values and the optimum doses of danofloxacin againstP. multocidaandH. parasuisin piglets. Single dose serum pharmacokinetics was determined in piglets after intravenous and intramuscular administration of 2.5 mg/kg. Danofloxacin was well absorbed and fully bioavailable (95.2%) after intramuscular administration of 2.5 mg/kg. The epidemiological cutoff (ECOFF) values of danofloxacin from 931P. multocidaisolates and 263H. parasuisisolates were 0.03 and 4 mg/L, respectively. Danofloxacin MICs determined in porcine serum were markedly lower than those measured in artificial broth, with a broth/serum ratio of 4.33 forH. parasuis. Compared toP. multocida, danofloxacin exhibited significantly longer post-antibiotic effects (3.18–6.60 h) and post-antibiotic sub-MIC effects (7.02–9.94 h) againstH. parasuis. The mean area under the concentration-time curve/MIC (AUC24h/MIC) targets of danofloxacin in serum associated with the static and bactericidal effects were 32 and 49.8, respectively, forP. multocida, whereas they were 14.6 and 37.8, respectively, forH. parasuis. Danofloxacin AUC24h/MIC targets for the same endpoints forP. multocidawere higher than those forH. parasuis. At the current dose of 2.5 mg/kg, the PK/PD cutoff (COPD) values of danofloxacin againstP. multocidaandH. parasuiswere calculated to be 0.125 and 0.5 mg/L, respectively, based on Monte Carlo simulations. The predicted optimum doses of danofloxacin for a probability of target attainment (PTA) of > 90% to cover the overall MIC population distributions ofP. multocidaandH. parasuisin this study were 2.38 and 13.36 mg/kg, respectively. These PK/PD-based results have potential relevance for the clinical dose optimization and evaluation of susceptibility breakpoints for danofloxacin in the treatment of swine respiratory tract infections involving these pathogens.
Reduced Graphene Oxide Aerogels with Functionalization-Mediated Disordered Stacking for Sodium-Ion Batteries
Authors: Park Jaehyeung , Sharma Jaswinder , Jafta Charl J. , He Lilin , Meyer Harry M. , Li Jianlin , Keum Jong K. , Nguyen Ngoc A. , Polizos Georgios
Published: February 2022

Surface modified reduced graphene oxide (rGO) aerogels were synthesized using the hydrothermal method. Ethylene diamine (EDA) and α-cyclodextrin (CD) were used to functionalize the surface of the graphene oxide layers. The oxygen reduction and surface modification occurred in-situ during the hydrothermal self-assembly process. The chemical functionality and structure of the resulting ethylene diamine modified (rGO-EDA) and cyclodextrin modified (rGO-CD) aerogels as well as of the pristine unmodified rGO aerogel were studied using XPS, SEM, XRD, and SANS techniques. The overall surface composition showed a significant decrease in the oxygen content for all synthesized aerogels. The surface modified aerogels were characterized by a disordered stacking of the assembled rGO layers. The surface functionalities resulted in a broad distribution of the interlayer spacing and introduced structural heterogeneities. Such disordered structures can enable a better adsorption mechanism of the sodium ions. Coin cells based on the synthesized aerogels and sodium metal were assembled and tested at several charge and discharge rates. The correlation between the surface functionality of the rGO, the induced structural heterogeneities due to the disordered stacking, and the electrochemical performance of sodium-ion batteries were investigated. Operando XRD measurements were carried out during the battery cycling to investigate the adsorption or intercalation nature of the sodiation mechanism.
Neurobiological and Pharmacological Perspectives of D3 Receptors in Parkinson’s Disease
Authors: Chagraoui Abdeslam , Di Giovanni Giuseppe , De Deurwaerdère Philippe
Published: February 2022

The discovery of the D3 receptor (D3R) subtypes of dopamine (DA) has generated an understandable increase in interest in the field of neurological diseases, especially Parkinson’s disease (PD). Indeed, although DA replacement therapy with l-DOPA has provided an effective treatment for patients with PD, it is responsible for invalidating abnormal involuntary movements, known as L-DOPA-induced dyskinesia, which constitutes a serious limitation of the use of this therapy. Of particular interest is the finding that chronic l-DOPA treatment can trigger the expression of D1R–D3R heteromeric interactions in the dorsal striatum. The D3R is expressed in various tissues of the central nervous system, including the striatum. Compelling research has focused on striatal D3Rs in the context of PD and motor side effects, including dyskinesia, occurring with DA replacement therapy. Therefore, this review will briefly describe the basal ganglia (BG) and the DA transmission within these brain regions, before going into more detail with regard to the role of D3Rs in PD and their participation in the current treatments. Numerous studies have also highlighted specific interactions between D1Rs and D3Rs that could promote dyskinesia. Finally, this review will also address the possibility that D3Rs located outside of the BG may mediate some of the effects of DA replacement therapy.
Molecular Mechanisms Related with Oligometastatic Prostate Cancer—Is It Just a Matter of Numbers?
Authors: Surcel Cristian , Kretschmer Alexander , Mirvald Cristian , Sinescu Ioanel , Heidegger Isabel , Tsaur Igor
Published: February 2022

During the last decade, the body of knowledge regarding the oligometastatic state has increased exponentially. Several molecular frameworks have been established, aiding our understanding of metastatic spread caused by genetically unstable cells that adapt to a tissue environment which is distant from the primary tumor. In the current narrative review, we provide an overview of the current treatment landscape of oligometastatic cancer, focusing on the current biomarkers used in the identification of true oligometastatic disease and highlighting the impact of molecular imaging on stage shift in different scenarios. Finally, we address current and future directions regarding the use of genetic and epigenetic targeting treatments in oligometastatic prostate cancer.
Physical Interaction between Embryonic Stem Cell-Expressed Ras (ERas) and Arginase-1 in Quiescent Hepatic Stellate Cells
Authors: Pudewell Silke , Lissy Jana , Nakhaeizadeh Hossein , Taha Mohamed S. , Akbarzadeh Mohammad , Rezaei Adariani Soheila , Nakhaei-Rad Saeideh , Li Junjie , Kordes Claus , Häussinger Dieter , Piekorz Roland P. , Cortese-Krott Miriam M. , Ahmadian Mohammad Reza
Published: February 2022

Embryonic stem cell-expressed Ras (ERas) is an atypical constitutively active member of the Ras family and controls distinct signaling pathways, which are critical, for instance, for the maintenance of quiescent hepatic stellate cells (HSCs). Unlike classical Ras paralogs, ERas has a unique N-terminal extension (Nex) with as yet unknown function. In this study, we employed affinity pull-down and quantitative liquid chromatography-tandem mass spectrometry (LC–MS/MS) analyses and identified 76 novel binding proteins for human and rat ERas Nex peptides, localized in different subcellular compartments and involved in various cellular processes. One of the identified Nex-binding proteins is the nonmitochondrial, cytosolic arginase 1 (ARG1), a key enzyme of the urea cycle and involved in the de novo synthesis of polyamines, such as spermidine and spermine. Here, we show, for the first time, a high-affinity interaction between ERas Nex and purified ARG1 as well as their subcellular colocalization. The inhibition of ARG1 activity strikingly accelerates the activation of HSCs ex vivo, suggesting a central role of ARG1 activity in the maintenance of HSC quiescence.
Decreased Concentration of Fibroblast Growth Factor 23 (FGF-23) as a Result of Supplementation with Selenium and Coenzyme Q10 in an Elderly Swedish Population: A Sub-Analysis
Authors: Alehagen Urban , Aaseth Jan , Larsson Anders , Alexander Jan
Published: February 2022

There is a reduced intake of selenium in many countries due to low levels of selenium in the soil. This results in an increased cardiovascular risk. Fibroblast growth factor 23 (FGF-23) is active mainly in the metabolism of vitamin D and phosphorus. However, there are indications that FGF-23 may also provide information both on cardiovascular function and prognosis. The aim of the study was to evaluate the effect of supplementation with selenium and coenzyme Q10 on the FGF-23 concentration in an elderly population with low concentrations of both selenium and coenzyme Q10 and in which the supplementation improved cardiac function and mortality. In a randomised double-blind placebo-controlled trial, FGF-23 was measured in 219 individuals at the start and after 48 months. Selenium yeast (200 µg/day) and coenzyme Q10 (200 mg/day) (n = 118) or placebo (n = 101) were given as a dietary supplement. The intervention time was 48 months. t-Tests, repeated measures of variance, and ANCOVA analyses were used to evaluate the differences in FGF-23 concentration. Following supplementation with selenium and coenzyme Q10, a significantly lower level of FGF-23 could be seen (p = 0.01). Applying 10 years of follow-up, those who later died a cardiovascular death had a significantly higher FGF-23 concentration after 48 months compared with those who survived (p = 0.036), and a significantly lower FGF-23 concentration could be seen in those with a normal renal function compared to those with an impaired renal function (p = 0.027). Supplementation with selenium and coenzyme Q10 to an elderly community-living population low in both substances prevented an increase of FGF-23 and also provided a reduced cardiovascular risk.
How Is Peripheral Injury Signaled to Satellite Glial Cells in Sensory Ganglia?
Authors: Hanani Menachem
Published: February 2022

Injury or inflammation in the peripheral branches of neurons of sensory ganglia causes changes in neuronal properties, including excessive firing, which may underlie chronic pain. The main types of glial cell in these ganglia are satellite glial cells (SGCs), which completely surround neuronal somata. SGCs undergo activation following peripheral lesions, which can enhance neuronal firing. How neuronal injury induces SGC activation has been an open question. Moreover, the mechanisms by which the injury is signaled from the periphery to the ganglia are obscure and may include electrical conduction, axonal and humoral transport, and transmission at the spinal level. We found that peripheral inflammation induced SGC activation and that the messenger between injured neurons and SGCs was nitric oxide (NO), acting by elevating cyclic guanosine monophosphate (cGMP) in SGCs. These results, together with work from other laboratories, indicate that a plausible (but not exclusive) mechanism for neuron-SGCs interactions can be formulated as follows: Firing due to peripheral injury induces NO formation in neuronal somata, which diffuses to SGCs. This stimulates cGMP synthesis in SGCs, leading to their activation and to other changes, which contribute to neuronal hyperexcitability and pain. Other mediators such as proinflammatory cytokines probably also contribute to neuron-SGC communications.
Impact of Different Metal Artifact Reduction Techniques on Attenuation Correction of Normal Organs in 18F-FDG-PET/CT
Authors: Morawitz Janna , Martin Ole , Boos Johannes , Sawicki Lino M. , Wingendorf Katrin , Sedlmair Martin , Mamlins Eduards , Antke Christina , Antoch Gerald , Schaarschmidt Benedikt M.
Published: February 2022

Purpose: To evaluate the impact of different metal artifact reduction algorithms on Hounsfield units (HU) and the standardized uptake value (SUV) in normal organs in patients with different metal implants. Methods: This study prospectively included 66 patients (mean age of 66.02 ± 13.1 years) with 87 different metal implants. CT image reconstructions were performed using weighted filtered back projection (WFBP) as the standard method, metal artifact reduction in image space (MARIS), and an iterative metal artifacts reduction (iMAR) algorithm for large implants. These datasets were used for PET attenuation correction. HU and SUV measurements were performed in nine predefined anatomical locations: liver, lower lung lobes, descending aorta, thoracic vertebral body, autochthonous back muscles, pectoral muscles, and internal jugular vein. Differences between HU and SUV measurements were compared using paired t-tests. The significance level was determined as p = 0.017 using Bonferroni correction. Results: No significant differences were observed between reconstructed images using iMAR and WFBP concerning HU and SUV measurements in liver (HU: p = 0.055; SUVmax: p = 0.586), lung (HU: p = 0.276; SUVmax: p = 1.0 for the right side and HU: p = 0.630; SUVmax: p = 0.109 for the left side), descending aorta (HU: p = 0.333; SUVmax: p = 0.083), thoracic vertebral body (HU: p = 0.725; SUVmax: p = 0.392), autochthonous back muscles (HU: p = 0.281; SUVmax: p = 0.839), pectoral muscles (HU: p = 0.481; SUVmax: p = 0.277 for the right side and HU: p = 0.313; SUVmax: p = 0.859 for the left side), or the internal jugular vein (HU: p = 0.343; SUVmax: p = 0.194). Conclusion: Metal artifact reduction algorithms such as iMAR do not alter the data information of normal organs not affected by artifacts.
Flywheel Energy Storage System in Italian Regional Transport Railways: A Case Study
Authors: Canova Aldo , Campanelli Federico , Quercio Michele
Published: February 2022

In this paper, we looked at the role of electromechanical storage in railway applications. A mathematical model of a running train was interfaced with real products on the electromechanical storage market supposed to be installed at the substation. Through this simulation, we gathered data on the recoverable energy of the system, its advantages, and its limitations. Various storage powers were run along variations in speed and gradient to paint a clearer picture of this application. Throughout these simulations, the energy savings were between 25% and 38%, saving up to 0.042 kWh/(seat km).
What Motivates Consumer Food Safety Perceptions and Beliefs? A Scoping Review in BRICS Countries
Authors: Zanetta Luis D’Avoglio , Mucinhato Raísa Moreira Dardaque , Hakim Mariana Piton , Stedefeldt Elke , da Cunha Diogo Thimoteo
Published: February 2022

This scoping review aimed to map the main evidence in the existing literature regarding consumer perceptions and beliefs regarding food safety in the context of BRICS (Brazil, Russia, India, China, and South Africa) countries. Articles were searched in the Web of Science, Scopus, and SciELO databases. The last search was performed on November 2021. Only the studies conducted within BRICS countries were included. The synthesis aimed to group similarities in consumer beliefs and perceptions of food safety. After screening, 74 eligible articles were included in the study. Of the 74 studies analyzed, 49 (66.2%) were carried out in China, 14 (18.9%) in Brazil, 5 (6.8%) in India,4 (5.4%) in South Africa, and 2 (2.7%) in Russia. Thirty-three motivators of perceptions and beliefs regarding food safety were identified. Food safety motivators were grouped into three categories: (1) sociodemographic characteristics, (2) cognitive aspects, and (3) other. In the “sociodemographic characteristics” category, the motivator with the highest number of corresponding results was education level (results = 22), followed by income (results = 22), both positive drivers for food safety perceptions. The “cognitive aspects” category comprised the majority of the identified motivators. Concern for food safety (results = 32) and risk perception (results = 30) were the motivators with the highest number of results among all categories and motivators. Finally, the main motivator in the “other” category was place of consumption/purchase (results = 8), focusing on consumers underestimating the risk of having a foodborne disease when eating away from home. China and Brazil are leading the way in studies on this topic. Consumers’ perceptions are influenced by socioeconomic characteristics (e.g., age, gender, education level, income), cognitive aspects (e.g., knowledge, risk perception, food concerns, previous experience with food safety incidents) and other situational factors (e.g., price, place of purchase, traceability).
SATELLITE: Application to Planetary Nebulae IFU Data
Authors: Akras Stavros , Monteiro Hektor , Walsh Jeremy R. , Aleman Isabel , Gonçalves Denise R. , Boumis Panayotis
Published: February 2022

The integral field unit (IFU) spectroscopic view of extended ionized nebulae, such as planetary nebulae (PNe), H II regions, and galaxies, has changed the approach of studying these objects, providing a simultaneous characterization in both spatial directions. However, the spatial spaxel-by-spaxel analysis of such nebulae through IFUs is not directly comparable with the results obtained from the traditional slit-aperture spectroscopy or the predictions from 1D modelling. The new Python software called “satellite: Spectroscopic Analysis Tool for intEgraL fieLd unIt daTacubEs” is used in the analysis of the VIMOS and MUSE datacubes of four Galactic PNe. The 2D analysis of line ratio maps has shown important variations from one to another nebular component in NGC 7009 and NGC 6778. In particular, the knots in both PNe are characterized by strong emission from neutral gas that is weak or even absent from the main nebula, indicating significant variation in the ionization state and density structure among the nebular components. The far-UV radiation from the central star results in the photo-evaporation of the dense molecular knots resembling the spectrum of photodissociation regions.
Inequality in Healthcare Utilization in Italy: How Important Are Barriers to Access?
Authors: Matranga Domenica , Maniscalco Laura
Published: February 2022

With the ageing population, equitable access to medical care has proven to be paramount for the effective and efficient management of all diseases. Healthcare access can be hindered by cost barriers for drugs or exams, long waiting lists or difficult access to the place where the needed healthcare service is provided. The aim of this paper is to investigate whether the probability of facing one of these barriers varies among individuals with different socio-economic status and care needs, controlling for geographical variability. Methods. The sample for this study included 9629 interviews with Italian individuals, aged 15 and over, from the second wave (2015) of the European Health Interview Survey, which was conducted in all EU Member States. To model barriers to healthcare, two-level variance components of logistic regression models with a nested structure given by the four Italian macro-areas were considered. Results. Of the barriers considered in this study, only two were found to be significantly associated with healthcare utilization. Specifically, they are long waiting lists for specialist service accessibility (adjOR = 1.20, 95% CI (1.07; 1.35)) and very expensive exams for dental visit accessibility (adjOR = 0.84, 95% CI (0.73; 0.96)). Another important result was the evidence of an increasing north–south gradient for all of the considered barriers. Conclusion. In Italy, healthcare access is generally guaranteed for all of the services, except for specialist and dental visits that face a waiting time and financial barriers. However, barriers to healthcare were differentiated by income and sex. The north–south gradient for healthcare utilization could be explained through the existing differences in organizational characteristics of the several regional healthcare services throughout Italy.
Conversion of Waste Cooking Oil to Rhamnolipid by a Newly Oleophylic Pseudomonas aeruginosa WO2
Authors: Shi Shu , Teng Zedong , Liu Jianwei , Li Tinggang
Published: February 2022

The components of waste cooking oil (WCO) are complex and contain toxic substances, which are difficult to treat biologically. Pseudomonas aeruginosa WO2 was isolated from oily sludge by an anaerobic enrichment–aerobic screening method, which could efficiently utilize WCO and produce rhamnolipid. The effects of nutrients and culture conditions on bacterial growth and lipase activity were investigated to optimize the fermentation of WCO. The results showed that strain WO2 utilized 92.25% of WCO and produced 3.03 g/L of rhamnolipid at 120 h. Compared with inorganic sources, the organic nitrogen source stabilized the pH of fermentation medium, improved lipase activity (up to 19.98 U/mL), and promoted the utilization of WCO. Furthermore, the WO2 strain exhibited inferior utilization ability of the soluble starch contained in food waste, but superior salt stress up to 60 g/L. These unique characteristics demonstrate the potential of Pseudomonas aeruginosa WO2 for the utilization of high-salinity oily organic waste or wastewater.