bluuebunny/crossref_metadata_2025 huggingface dataset:
Projecting requirements for end stage renal disease services in Libya 2014-2024
Authors: Akkari Khalid
Published: July 2017

Chronic kidney disease is a public health issue with significant humanitarian and economic implications. Between 2007 and 2009, the number of patients on dialysis in Libya increased from 2116 to 2417. It is projected that the number of patients on dialysis will increase from 2417 in 2009 to 7667 in 2024. The proportion of patients on peritoneal dialysis is projected to rise from 1.2% in 2014 to 16% in 2024. To maintain a patient to dialysis machine ratio of 1: 3.4, the number of dialysis machines will need to grow from 1045 in 2014 to 2255 in 2024. Hemodialysis units are better organized into main and satellite units, with a potential use of mobile hemodialysis units to deliver a local service to much smaller number of hemodialysis patients. The required number of general nephrology beds in 2014 is estimated around 468, with 59 additional regional transplant beds. These numbers are expected to be around 547 and 69 respectively by 2024. Required staff to deliver service to these rising numbers of patients is estimated to be 78 nephrologists, 9 vascular access surgeons, 4 transplant surgeons and 4 hepatologists in 2014. The corresponding numbers in 2024 are 123, 51, 18, and 7, respectively. The number of required renal nurses in 2014 is 1767, rising to 3400 by 2024. A steady increase in the number of required transplant coordinators, histocompatibility and immunogenetics laboratory consultants and scientists, dialysis technicians, renal dietitians, social workers, clinical psychologists and clinical renal pharmacists is to be expected. Recently published data showing great variability in patient mortality, hepatitis sero-conversion rates and the lack of consistent practice to check dialysis dose and adequacy are strong indicators for the nephrology community in Libya, the regulatory authorities and decision makers to urgently agree national nephrology clinical practice guidelines, and to adequately plan to train and develop the skills of the personnel required to cope with the rising number of end stage renal disease patients.
Desastre, destruição, criação: do nada às cinzas
Authors: Terenzi Juan Manuel
Published: July 2017

http://dx.doi.org/10.5007/2175-7917.2016v21n1p114Este artigo propõe discutir, de maneira sucinta, acerca do nada, do fogo, das cinzas e do poder de criação que deles deriva. Para levar a cabo esta discussão, inicialmente nos valeremos de alguns conceitos filosóficos abordados por Martin Heidegger. Em seguida, discutiremos a leitura efetuada por Jacques Derrida sobre o conceito de Geist (Espírito) em Heidegger. Derrida irá investigar o uso desta palavra e suas variantes ao longo da obra filosófica de Heidegger, identificando possíveis leituras que estariam ocultas e que descortinariam um teatro heideggeriano em torno desta palavra. A leitura do filósofo da desconstrução tece importantes considerações e permite ao leitor novas aproximações à obra heideggeriana.  Com estes dois eixos definidos, elaboramos uma leitura que põe de manifesto a relação entre os seguintes conceitos: o nada, o fogo e as cinzas, relacionados com o ato de criação. Ao longo do artigo destacamos outros escritores e filósofos, tais como Heráclito, Habermas, Wittgenstein e Beckett.
A negra que não está na capa de revista: debates sobre raça e gênero
Authors: Bittelbrun Gabrielle Vivian
Published: July 2017

http://dx.doi.org/10.5007/2175-7917.2016v21n1p170As capas das revistas femininas são conhecidas por destacar personalidades que sejam referenciais de beleza, ícones de estilo de vida e reconhecidas pelo grande público. Mas, no que se refere à aparência, nota-se a seleção quase absoluta de personagens brancas, o que pode servir como pano de fundo para se analisar a temática racial no Brasil. Afinal, enquanto contribuem para a manutenção do corpo branco em um lugar privilegiado, revistas consolidadas no mercado editorial brasileiro, como é o caso dos títulos Claudia e TPM, não deixam de reforçar a invisibilização das negras. Nesse espaço, pretende-se discutir tais questões, admitindo-se ainda que são resultado de um processo histórico, remetendo à ideologia de branqueamento, ao mesmo tempo em que escondendo discriminações por baixo da problemática máxima de “democracia racial”. Faz-se indispensável também debater como o quesito “raça” se delineou no contexto brasileiro e levantar possibilidades de subversão a partir do uso político do termo, defendido por Guimarães (2002) e Schwarcz (2012).
Gregório de Matos, nosso primeiro antropófago
Authors: De Oliveira Lima Samuel Anderson
Published: July 2017

http://dx.doi.org/10.5007/2175-7917.2016v21n1p46A figura exponencial de Gregório de Matos tem sido, ao longo dos anos, motivo de muitas discussões teóricas. Nesse panorama, ainda existem dois lados antagônicos quando se trata da poesia de Gregório de Matos, os que o defendem e os que o acusam. Os primeiros defendem a posição de que o poeta baiano foi a primeira voz literária no Brasil alçada sob as bases do Barroco, e os outros o acusam de ser ele um mero imitador dos poetas espanhóis do século XVII, sem, portanto, ter contribuído significativamente para a formação da Literatura Brasileira. Este artigo, que é fruto de uma pesquisa de doutoramento, segue o pensamento daqueles que defendem o poeta como barroco-antropofágico, devorador de culturas, com participação ativa no processo de formação da nossa identidade cultural e literária. Ancorado pelo pensamento crítico dos irmãos Campos, nosso trabalho busca observar e discutir a hipótese de que Gregório de Matos foi nosso primeiro antropófago, sendo possível enxergar em seus poemas as características intrínsecas do movimento antropofágico, idealizado por Oswald de Andrade no século XX.
Imagem-palavra: a iconicidade da escrita em "Relato de um certo oriente", de Milton Hatoum
Authors: Pimentel Daiane Carneiro
Published: July 2017

http://dx.doi.org/10.5007/2175-7917.2016v21n1p58O presente artigo propõe-se a demonstrar que o romance Relato de um Certo Oriente, de Milton Hatoum (1989), explicita a afinidade entre o ler e o ver, afinidade essa que remonta a origens icônicas da escrita. Apesar de não apresentar nenhuma imagem material em suas páginas nem explorar a dimensão gráfica das letras com que é composta, a obra em questão procura restabelecer os elos entre o verbal e o visual por meio da referência ao alfabeto árabe, à leitura da borra de café, às formas expressivas de Soraya Ângela e ao cometa escrito/desenhado por Dorner. Dessa maneira, o romance de Hatoum, ao abordar a iconicidade da escrita, não apenas sugere a semelhança entre os gestos dos artistas da palavra e dos artistas da imagem como também corrobora a crítica ao “alfabetocentrismo”, o qual, conforme Roland Barthes (2004), negligencia o aspecto criptográfico, ritualístico e simbólico que caracteriza a prática da escrita.
A experiência revisitada: as artimanhas naturais da narrativa rosiana
Authors: Haudenschild André Rocha Leite
Published: July 2017

http://dx.doi.org/10.5007/2175-7917.2016v21n1p81O artigo pretende elaborar considerações sobre a narrativa do poeta e romancista Guimarães Rosa à luz das teorias de Walter Benjamin sobre o narrador e as transformações da experiência, mediadas pelas análises críticas de José Guilherme Merquior e Davi Arrigucci Júnior. Assim almeja-se compreender como que a prosa poética de Guimarães Rosa transita com autoridade da Erfahrung à Erlebnis benjaminiana, subindo e descendo os degraus da experiência entre os universos culturais do “sertão” e da “metrópole” ao deslocar-se entre a oralidade sertaneja e o romance de formação. Trata-se de entender essa tensão civilizatória como uma chave interpretativa que nos permite adquirirmos consciência de uma parte central de nossa experiência e das crises de nossa sociedade (WILLIAMS, 1989): uma antinomia crucial que está atrelada ao próprio modo de produção capitalista que vem transformando a vida social brasileira desde as primeiras décadas do século XX. Para tanto, foram elencadas algumas das principais obras da produção literária rosiana, como Grande sertão: veredas e alguns contos pertinentes para exemplificarem as argumentações propostas neste trabalho.
Wallace Stevens: o hermetismo como leitura do real
Authors: Fumaneri Maria Luísa
Published: July 2017

http://dx.doi.org/10.5007/2175-7917.2016v21n1p92A poesia de Wallace Stevens (1879-1955) é sempre considerada um desafio à interpretação, coerente com a tradição do modernismo de Stéphane Mallarmé em Um lance de dados, graças à sua obscuridade e conteúdo filosófico. O objetivo deste trabalho é mostrar como esse paralelo entre a obra dos dois poetas pode elucidar alguns problemas que assombram a interpretação de poesia moderna, a saber: as ligações entre linguagem e realidade e o papel da poesia no conhecimento. Primeiramente, há uma análise do significado do problema, da forma como aparece na obra-prima de Mallarmé. Depois, uma tentativa de demonstrar, em alguns poemas do autor americano, como o problema é formulado em outros termos em sua teoria da poesia como Ficção Suprema. Para estes fins, os poemas escolhidos foram “Treze maneiras de olhar para um melro” e “O homem da guitarra azul”, na medida em que eles demonstram duas formas diferentes de abordar a questão da relação entre representação poética e realidade.
Mário de Sá-Carneiro e a festa parisiense da belle époque
Authors: Silva Teresa Cristina Cerdeira da
Published: July 2017

http://dx.doi.org/10.5007/2175-7917.2016v21n2p21O episódio da Festa da Americana em A Confissão de Lúcio dá a ver a ambiência da Belle Époque parisiense. A Festa desempenha aí um duplo papel: o da teatralização e o do aprendizado. De um lado, essa orgia mágica ilustra perfeitamente a noção batalliana de “despesa” da qual se afastam as limitações e as regras do trabalho. De outro, pode-se certamente ver aí o amálgama inesperado do gozo e da aptidão intelectual, da desmedida orgíaca e da busca espiritual, o que faz pensar no Banquete platônico. Esse refinamento erótico da linguagem não está longe das linhas sinuosas, das volutas e da ornamentação da Arte Nova em que se destaca a Belle Époque Francesa. A herança impressionista do jogo de cores, a aventura baudelairiana da correspondência das sensações, a experiência conjunta de excesso e de sutileza oferecem aos expectadores uma mise en scène da voluptuosidade, tal como a concebe essa estranha mulher, espécie de porta-voz do autor que, como tantos outros artistas, veio a Paris no alvorecer do século XX para experimentar o gozo da modernidade.
Theoretical analysis of mixing in liquid clouds. Part IV: DSD evolution and mixing diagrams
Authors: Pinsky Mark , Khain Alexander
Published: July 2017

Abstract. Evolution of droplet size distribution (DSD) due to mixing between cloudy and dry volumes is investigated for different values of the cloud fraction and different initial DSD shapes. The analysis is performed using a diffusion-evaporation model which describes time-dependent processes of turbulent diffusion and droplet evaporation within a mixing volume. Time evolution of the DSD characteristics such as droplet concentration, liquid water content, mean volume and the effective radii is analyzed. The mixing diagrams are plotted for the final mixing stages. It is shown that the difference between the mixing diagrams for homogeneous and inhomogeneous mixing is insignificant and decreases with an increase in the DSD width. The dependencies of normalized cube of the effective radius on the cloud fraction were compared with those on normalized droplet concentration and found to be quite different. In case the normalized droplet concentration is used, mixing diagrams do not show any significant dependency on relative humidity in the dry volume. The main conclusion of the study is that traditional mixing diagrams cannot serve as a reliable tool in analysis of mixing type.
Our dynamic sun: 2017 Hannes Alfvén Medal lecture at the EGU
Authors: Priest Eric
Published: July 2017

Abstract. This lecture summarises how our understanding of many aspects of the Sun has been revolutionised over the past few years by new observations and models. Much of the dynamic behaviour of the Sun is driven by the magnetic field since, in the outer atmosphere, it represents the largest source of energy by far. The interior of the Sun possesses a strong shear layer at the base of the convection zone, where sunspot magnetic fields are generated. A small-scale dynamo may also be operating near the surface of the Sun, generating magnetic fields that thread the lowest layer of the solar atmosphere, the turbulent photosphere. Above the photosphere lies the highly dynamic fine-scale chromosphere, and beyond that is the rare corona at high temperatures exceeding 1 million degrees K. Possible magnetic mechanisms for heating the corona and driving the solar wind (two intriguing and unsolved puzzles) are described. Other puzzles include the structure of giant flux ropes, known as prominences, which have complex fine structure. Occasionally, they erupt and produce huge ejections of mass and magnetic fields (coronal mass ejections), which can disrupt the space environment of the Earth. When such eruptions originate in active regions around sunspots, they are also associated with solar flares, in which magnetic energy is converted to kinetic energy, heat and fast-particle energy. A new theory will be presented for the origin of the twist that is observed in erupting prominences and for the nature of reconnection in the rise phase of an eruptive flare or coronal mass ejection.
Characterization of “dead-zone” eddies in the eastern tropical North
Atlantic
Authors: Schütte Florian , Karstensen Johannes , Krahmann Gerd , Hauss Helena , Fiedler Björn , Brandt Peter , Visbeck Martin , Körtzinger Arne
Published: July 2017

Abstract. Localized open-ocean low-oxygen “dead zones” in the eastern tropical North Atlantic are recently discovered ocean features that can develop in dynamically isolated water masses within cyclonic eddies (CE) and anticyclonic mode-water eddies (ACME). Analysis of a comprehensive oxygen dataset obtained from gliders, moorings, research vessels and Argo floats reveals that “dead-zone” eddies are found in surprisingly high numbers and in a large area from about 4 to 22° N, from the shelf at the eastern boundary to 38° W. In total, 173 profiles with oxygen concentrations below the minimum background concentration of 40 µmol kg−1 could be associated with 27 independent eddies (10 CEs; 17 ACMEs) over a period of 10 years. Lowest oxygen concentrations in CEs are less than 10 µmol kg−1 while in ACMEs even suboxic (< 1 µmol kg−1) levels are observed. The oxygen minimum in the eddies is located at shallow depth from 50 to 150 m with a mean depth of 80 m. Compared to the surrounding waters, the mean oxygen anomaly in the core depth range (50 and 150 m) for CEs (ACMEs) is −38 (−79) µmol kg−1. North of 12° N, the oxygen-depleted eddies carry anomalously low-salinity water of South Atlantic origin from the eastern boundary upwelling region into the open ocean. Here water mass properties and satellite eddy tracking both point to an eddy generation near the eastern boundary. In contrast, the oxygen-depleted eddies south of 12° N carry weak hydrographic anomalies in their cores and seem to be generated in the open ocean away from the boundary. In both regions a decrease in oxygen from east to west is identified supporting the en-route creation of the low-oxygen core through a combination of high productivity in the eddy surface waters and an isolation of the eddy cores with respect to lateral oxygen supply. Indeed, eddies of both types feature a cold sea surface temperature anomaly and enhanced chlorophyll concentrations in their center. The low-oxygen core depth in the eddies aligns with the depth of the shallow oxygen minimum zone of the eastern tropical North Atlantic. Averaged over the whole area an oxygen reduction of 7 µmol kg−1 in the depth range of 50 to 150 m (peak reduction is 16 µmol kg−1 at 100 m depth) can be associated with the dispersion of the eddies. Thus the locally increased oxygen consumption within the eddy cores enhances the total oxygen consumption in the open eastern tropical North Atlantic Ocean and seems to be an contributor to the formation of the shallow oxygen minimum zone.
Dynamic data transmission technology for expendable current profiler based on low-voltage differential signaling
Authors: Li Shuhan , Zhang Qisheng , Zhao Xiao , Liu Shenghui , Yuan Zhenzhong , Zhang Xinyue
Published: July 2017

Abstract. A dynamic data transmission technology for expendable current profilers (XCPs) is proposed in this paper. Two parallel varnished wires are employed as the data transmission medium. By testing the transmission properties of the varnished wires, a baseband transmission system is studied and designed. Modified low-voltage differential signaling (LVDS) is adopted as the physical layer for data transmission. The data transmission protocol is modified and optimized in accordance with the RS-232 protocol, and the Manchester code is superimposed. According to the results of indoor and marine tests, the data transmission distance of the designed system, which employs a 0.1 mm diameter varnished wire, extends to 2 km with high efficiency and accuracy for data transmission, exhibiting excellent performance. Moreover, this data transmission technology could be used for other expendable marine-environment parametric measuring instruments such as an expendable bathythermograph and an expendable conductivity temperature depth profiler.
Future shift of the relative roles of precipitation and temperature in
controlling annual runoff in the conterminous United States
Authors: Duan Kai , Sun Ge , McNulty Steven G. , Caldwell Peter V. , Cohen Erika C. , Sun Shanlei , Aldridge Heather D. , Zhou Decheng , Zhang Liangxia , Zhang Yang
Published: July 2017

Abstract. This study examines the relative roles of climatic variables in altering annual runoff in the conterminous United States (CONUS) in the 21st century, using an ecohydrological model driven with historical records and future scenarios constructed from 20 Coupled Model Intercomparison Project Phase 5 (CMIP5) climate models. The results suggest that precipitation has been the primary control of runoff variation during the latest decades, but the role of temperature will outweigh that of precipitation in most regions if future climate change follows the projections of climate models instead of the historical tendencies. Besides these two key factors, increasing humidity is projected to partially offset the additional evaporative demand caused by warming and consequently enhance runoff. Overall, the projections from 20 climate models suggest a high degree of consistency on the increasing trends in temperature, precipitation, and humidity, which will be the major climatic driving factors accounting for 43 % ~ 50 %, 20 % ~ 24 %, and 16 % ~ 23 % of runoff change, respectively. Spatially, while temperature rise is recognized as the largest contributor in most of the CONUS, precipitation is expected to be the dominant factor driving runoff to increase across the Pacific Coast and the Southwest. The combined effects of increasing humidity and precipitation may also surpass the detrimental effects of warming and result in a hydrologically wetter future in the East. However, severe runoff depletion is more likely to occur in the Midwest and South-Central.
Analysis of single-Alter-shielded and unshielded measurements of mixed and solid precipitation from WMO-SPICE
Authors: Kochendorfer John , Nitu Rodica , Wolff Mareile , Mekis Eva , Rasmussen Roy , Baker Bruce , Earle Michael E. , Reverdin Audrey , Wong Kai , Smith Craig D. , Yang Daqing , Roulet Yves-Alain , Buisan Samuel , Laine Timo , Lee Gyuwon , Aceituno Jose Luis C. , Alastrué Javier , Isaksen Ketil , Meyers Tilden , Brækkan Ragnar , Landolt Scott , Jachcik Al , Poikonen Antti
Published: July 2017

Abstract. Although precipitation has been measured for many centuries, precipitation measurements are still beset with significant inaccuracies. Solid precipitation is particularly difficult to measure accurately, and wintertime precipitation measurement biases between different observing networks or different regions can exceed 100 %. Using precipitation gauge results from the World Meteorological Organization Solid Precipitation Intercomparison Experiment (WMO-SPICE), errors in precipitation measurement caused by gauge uncertainty, spatial variability in precipitation, hydrometeor type, crystal habit, and wind were quantified. The methods used to calculate gauge catch efficiency and correct known biases are described. Adjustments, in the form of transfer functions that describe catch efficiency as a function of air temperature and wind speed, were derived using measurements from eight separate WMO-SPICE sites for both unshielded and single-Alter-shielded precipitation-weighing gauges. For the unshielded gauges, the average undercatch for all eight sites was 0.50 mm h−1 (34 %), and for the single-Alter-shielded gauges it was 0.35 mm h−1 (24 %). After adjustment, the mean bias for both the unshielded and single-Alter measurements was within 0.03 mm h−1 (2 %) of zero. The use of multiple sites to derive such adjustments makes these results unique and more broadly applicable to other sites with various climatic conditions. In addition, errors associated with the use of a single transfer function to correct gauge undercatch at multiple sites were estimated.
Understanding shallow landslides in Campos do Jordão Municipality – Brazil: disentangle the anthropic effects from natural causes in the disaster of 2000
Authors: Mendes Rodolfo Moreda , de Andrade Márcio Roberto Magalhães , Tomasella Javier , de Moraes Márcio Augusto Ernesto , Scofield Graziela Balda
Published: July 2017

Abstract. Located in a mountain area of Southeast Brazil, the municipality of Campos do Jordao has been hit by several landslides in recent history. Among those events, the landslides of early 2000 were significant for the number of deaths (10), the population affected and the destruction of infrastructure that caused. The purpose of this study is to assess the relative contribution of natural and human factors in triggering the landslides of the 2000 event. To achieve this goal, a detailed geotechnical survey was conducted in three representative slopes of the area to obtain geotechnical parameters needed for slope stability analysis. Then, a set of numerical experiment with Geo-Slope software was designed including natural and anthropic factors separately. Results showed that natural factors, thus is, high intensity rainfall and geotechnical conditions, were not severe enough to trigger landslides in the study area and that human disturbance were entirely responsible for the landslides events of 2000. Since the anthropic effects used in the simulations are typical of Brazilian hazardous urban areas, we concluded that the implementation of public policies that constrain the occupation of landslide susceptible areas are urgently needed
Carbonic Anhydrase Inhibitor with Topical NSAID Therapy to Manage Cystoid Macular Edema in a Case of Gyrate Atrophy
Authors: Piozzi Elena , Alessi Salvatore , Santambrogio Silvia , Cillino Giovanni , Mazza Marco , Iggui Aissa , Cillino Salvatore
Published: July 2017

Purpose

Gyrate atrophy of the choroid and retina (GACR) is a rare chorioretinal dystrophy characterized by a deficiency of the enzyme ornithine aminotransferase, inherited in an autosomal recessive pattern.

Case Report

We report a case of a 17-year-old girl with GACR, for whom the level of serum ornithine had been reduced by an arginine-restricted diet. The patient was responsive to an association of topical nonsteroidal anti-inflammatory drugs (NSAIDs) and a carbonic anhydrase inhibitor (CAI) to reduce cystoid macular edema (CME).

Conclusions

The efficacy of topical NSAIDs and systemic CAI association indicates that the imbalance in the distribution of retinal pigment epithelium membrane-bound carbonic anhydrase could play a major role in CME pathogenesis in GACR. To our knowledge, this is the first case of therapy with CAI treatment for GACR-related CME.
Colonoscopy in Automated Peritoneal Dialysis Patients: Value of Prophylactic Antibiotics: A Prospective Study on a Single Antibiotic
Authors: Al-Hwiesh Abdullah K. , Abdul-Rahman Ibrahiem S. , Hussameldeen Mohammad A. , Al-Audah Nadia , Abdelrahman Abdalla , Moaigel Hala M. , El-Salamony Tamer , Noor Abdul-Salam , Al-Osail Aisha , Al-Sayel Dalai , Al-Dossari Nourah
Published: July 2017

Objective

To evaluate the need for prophylactic antibiotics in automated peritoneal dialysis (APD) patients undergoing flexible colonoscopy.

Patients and Methods

A total of 93 patients on automated peritoneal dialysis (APD) undergoing diagnostic colonoscopy were enrolled in a prospective, randomized study. Patients were randomized into 2 age- and sex-matched groups; group A (46 patients) with intraperitoneal (IP) ceftazidime prior to colonoscopy and group B (47 patients) without prophylactic antibiotics. The relations between peritonitis and different parameters were analyzed.

Results:

Of all colonoscopies, 60.2% showed normal findings, 17.2% with colonic polyps at different sites, 12.9% with angiodysplastic-like lesions, 5.4% with colonic ulcer(s), 3.2% with diverticulae without diverticulitis and 1.1% had transverse colon stricture. Post-colonoscopy peritonitis was documented in 3 (6.5%) and 4 (8.5%) patients in groups A and B, respectively (p = 0.2742); the causative organisms were mainly gram negative bacteria. Polypectomy was not associated with increased peritonitis episodes. By multiple logistic regression analysis, diabetes mellitus was the only independent variable that entered into the best predictive equation over the development of post-colonoscopy peritonitis but not antibiotic use.

Conclusions

The relation between prophylactic antibiotic use prior to colonoscopy in APD patients and the risk of peritonitis was lacking. Only diabetes mellitus appears to be of significance. Polypectomy did not increase peritonitis episodes.
Paul Klee's illness – a series of historical and clinical vignettes
Authors: Silver Richard M.
Published: July 2017

Paul Klee (1879-1940) is undoubtedly the most notable historical figure to have suffered from systemic sclerosis (scleroderma). In this, the first in a series of vignettes on Klee's illness, I will explore a likely early feature of his condition - Raynaud phenomenon. In subsequent vignettes I will highlight other features of Klee's condition.
Ibrutinib Treatment of a Patient with Relapsing Chronic Lymphocytic Leukemia and Sustained Remission of Richter Syndrome
Authors: Albi Elisa , Baldoni Stefano , Aureli Patrizia , Dorillo Erica , Del Papa Beatrice , Ascani Stefano , Di lanni Mauro , Falzetti Franca , Sportoletti Paolo
Published: July 2017

Purpose

Richter syndrome (RS) is a rare event in chronic lymphocytic leukemia (CLL) that is influenced by biological factors and prior CLL treatments. Ibrutinib is a Bruton tyrosine kinase inhibitor that has shown remarkable efficacy in CLL; however, little is known about its relationship to RS. We report a case of ibrutinib efficacy against CLL in a patient with prolonged remission of RS.

Methods

The patient was diagnosed with CLL in 2003. Biological findings at onset included absent ZAP70 expression, mutated IGVH, and NOTCH1 mutation. He was treated with FCR with partial response. In 2013, he progressed to RS, not clonally related to the underlying CLL. The patient was treated with anthracycline- and platinum-based regimens, obtaining a complete remission. After 3 years, he presented a CLL progression with worsening lymphocytosis, anemia, thrombocytopenia, increased splenomegaly, and lymphadenopathies. Positron emission tomography-computed tomography scan excluded pathologic uptake. Thus, he was started on ibrutinib.

Results

At 12 months’ follow-up, we observed white blood cell normalization, increased hemoglobin and platelet levels, disappearance of lymphadenopathy, and spleen size reduction. Therapy was well-tolerated with no evidence of RS.

Conclusion

This case demonstrates sustained RS remission in a patient with CLL under ibrutinib therapy, thus improving our knowledge on the use of this new drug in CLL and beyond.
A Giant Intradiaphragmatic Bronchogenic Cyst: Case Report and Literature Review
Authors: Gao Xin , Zhai Min , Zhang Haitao , Wang Yunliang , Zhou Jin
Published: July 2017

Bronchogenic cysts are congenital lesions developing during early embryogenesis. The intradiaphragmatic location is extremely rare. We present a giant bronchogenic cyst arising from the left crus of diaphragm. Based on our literature review results, intradiaphragmatic bronchogenic cysts have the following characteristics: 1) they are more common in female patients; 2) the patients are usually asymptomatic, or present with symptoms of chest pain, abdominal pain, and hiccups; 3) the cysts located in the left diaphragm are more than those in the right diaphragm, most of which are located in the area of the left diaphragm crus.
Price Competition within and between Airlines and High-Speed Trains: The Case of the Milan—Rome Route
Authors: Abrate Graziano , Viglia Giampaolo , García Javier Sanchez , Forgas-Coll Santiago
Published: July 2017

In the travel industry high-speed trains and airlines are increasingly competing for passengers, and the diffusion of price optimization based on real time demand fluctuations poses new challenges in the analysis of price competition between operators. This paper presents an analysis of how different competitors simultaneously adjust their prices in the short run. The empirical model accounts for dynamic price variations, exploring both intramodal and intermodal price competition. The results, based on 12,506 price observations, show that intermodal competition presents some kind of asymmetric behaviour, with airlines reacting more than trains to competitors' price changes. The paper concludes with the implications of this heterogeneous behaviour for the tourism and travel industries.
Manejo do Dinheiro e Qualidade Conjugal.
Authors: Harth Jeniffer , Falcke Denise
Published: July 2017

A qualidade conjugal é influenciada por diversos fatores, dentre eles, o dinheiro. Sendo assim,objetivou-se investigar a relação entre o manejo do dinheiro e a qualidade conjugal. Realizouseuma pesquisa quantitativa com delineamento correlacional. Participaram 143 casais, casadosoficialmente ou morando juntos, entre 19 e 81 anos. Aplicou-se um questionário sociodemográfico,a DAS, o GRIMS e um questionário sobre manejo do dinheiro. Foram feitas análisesdescritivas e inferenciais. Os resultados revelaram que a maioria dos casais (58%) utiliza osistema de gestão compartilhada do dinheiro, enquanto que 25% manejam separadamente e17% delegam a um dos cônjuges o manejo. Os casais que compartilham o manejo financeiroobtiveram maiores níveis de qualidade conjugal e maior grau de felicidade com o relacionamento.Esses resultados corroboram com estudos anteriores, confirmando que o manejo dodinheiro está associado com a qualidade conjugal.
Exploring the Knowledge and Attitude of Engineering Students in the Imitation of Theoretical Knowledge
Authors: Salah Wael A. , Abu Sneineh Anees
Published: July 2017

In this paper an exploration of the engineering student’s knowledge in different engineering simulation tools to validate the theoretical knowledge leaned were conducted. The study cover students from different courses taught at different degree levels. A survey was conducted among the students in the academic years of 2014/2015 and 2015/2016 for students attending the class of Electronics (second year level), power electronics class (third year level) and Electrical measurement class (fourth year level). A personal interview was also conducted to capture the feedback from the learners under interest. The main aim is to accrue the attitude of engineering students to apply the knowledge throughout the Imitation of theoretical knowledge using modern virtual tools.
Transparantie van het wetgevingsproces: een kijk vanuit de wetgevingspraktijk
Authors: Borman T.C
Published: July 2017

Transparantie van het wetgevingsproces: een kijk vanuit de wetgevingspraktijk

Deze bijdrage beoogt een overzicht te bieden van relevante actuele ontwikkelingen op het terrein van transparantie van het wetgevingsproces in Nederland. Dit naar aanleiding van de op 24 februari 2017 uitgebrachte kabinetsnotitie over dit onderwerp. Belangrijke dilemma’s zijn het vinden van een balans tussen het belang van transparantie en het belang van beleidsintimiteit en het feit dat transparantie tijd en geld kost. In deze bijdrage wordt ingegaan op enkele specifieke onderwerpen die in de kabinetsnotitie wel – en in één geval juist niet – zijn belicht: de ‘lobbyparagraaf’ in de toelichting bij wettelijke regelingen, internetconsultatie, de ‘wetgevingskalender’ en transparantie in de Raad-van-State-fase.
OJS for Editors
Authors: PKP-OJS - , Frederiksen Niels Erik
Published: July 2017

Her er hvad udviklerne bag OJS selv skriver i introduktionen til dette kursus:

"This course will help you become an expert with the OJS editorial workflow."

Og det har de absolut ret i. Læseren får en grundig indføring i hele det redaktionelle workflow fra forfatterens upload af manuskript over kommunikation med bedømmer og forfatter til korrekturlæsning og publicering.

PKP-OJS (Forfatter) Niels Erik Frederiksen (Redaktør af dette tidsskrift)
Ungdomslitteratur former(er) sig
Authors: Henkel Ayoe Quist
Published: July 2017

“Young Adult Literature in Transformation”Through a media attentive analysis of the novel Akavet by Ronnie Andersen (2014) and brief discussions of other popular novels for and about young adults, this article examines the way young adult literature develops in dialogue with digital and media-based impulses and the consequences this development may have for the predication of youth and the aesthetics and possible characteristics of young adult literature. The article is based on a materiality approach especially inspired by N. Katherine Hayles which has not previously been given attention in the reading of young adult literature or in discussions of possible characteristics of young adult literature. It also includes a discussion of and a variation of Hayles’ triad of form, content and medium, and it assigns a special role to the reader’s articulation inasmuch as Akavet entails a denaturalization of the reading process. From this basis it discusses the classic assumption that young adult literature is about young people’s development process from childhood to adulthood, outlining a passage characterized by linearity, maturity and growth. The article concludes that some young adult literature is realized on yet other premises and that Akavet can be seen as an exponent for a movement from young adult literature as stories of coming-of-age to stories of being-in-age.
Politisk børnelitteratur. En børnelitteraturhistorisk bog om et radikalt årti
Authors: Simonsen Karen-Margrethe
Published: July 2017

Anmeldelse af Torben Weinreich: Den socialistiske børnebog. Frederiksberg: Roskilde Universitetsforlag, 2015, 229,95 kr., 130 sider.
Faglighed – kvalitet, æstetik og undervisning
Authors: Adamsen Johannes
Published: July 2017

In mainstream educational trends and in particular in public debate, one might perceive a rather superﬁ cial/uncritical handling of the concept of ‘subject matter’ (Danish: faglighed), a handling which inﬂ uences political decisions considerably. This article sets out to analyze the concept of ‘subject matter’ and makes the point that it is both intimately connected to a one dimensional idea of utility and that it as concept marginalizes teaching’s nature of encounter and dialogue, and hereby narrows ‘school’ to ‘learning’ and to some few basic subjects. Furthermore the argument is made that by comparing this narrow utility-like concept to the aesthetics the concept of subject matter can be qualiﬁ ed as closely bound to a form-content side and this in turn opens up to the aspect of character formation (Danish: dannelse; German: Bildung).
Jagten på en ADHD-diagnose: Analyse af situationer og kontekster, hvor det bliver attraktivt at være psykisk syg
Authors: Berger Nichlas Permin , Johansen Katrine Schepelern
Published: July 2017

Med udgangspunkt i cases fra to feltstudier beskriver forfatterne, hvordan ADHD-diagnosen af flere forskellige grunde bliver attraktiv for professionelle og klienter med stofmisbrug i Kriminalforsorgens institutioner og i stofmisbrugsbehandlingsinstitutioner. Studierne fandt, at diagnosen bidrager med nye forklaringer til at forstå menneskers komplekse og vanskelige livsforløb og adfærdsmæssige problemstillinger. Det står centralt, at kriminel adfærd – ofte den udadreagerende og voldelige – samt stofbrug opfattes som symptomer på at have ADHD. Som en integreret del af dagligdagssproget indgår diagnosen som ressource og aktiv komponent i de indsattes identitetsarbejde, hvor stigma og afvigelser transformeres til sygdom, som kan behandles gennem brug af lovlig medicin fremfor illegale stoffer. ADHD-diagnosen giver de professionelle nogle særlige forståelser af de udfordringer, som de møder i deres klientrelaterede arbejde, da ADHD-diagnosen forskyder problematisk adfærd fra spørgsmål om moral eller jura til spørgsmål om psykisk sygdom. Afslutningsvist relateres fundene til Nikolas Roses teorier om livets politik og biologisering, og hvordan skellet mellem normalitet og patologi udviskes.The pursuit of an ADHD diagnosis: Analysis of situations and contexts in which it becomes advantageous to be mentally illBased on the cases of two field studies, the authors describe how, for several reasons, the ADHD diagnosis can become an advantageous diagnosis for professionals and clients with substance abuse in institutions under the Prison and Probation Service and in substance abuse treatment facilities. The studies found that the diagnosis contributes new explanations for understanding individuals’ complex and difficult life courses and behavioral issues. A crucial point is that criminal behavior – often of an outward reacting and violent kind – and drug use are seen as symptoms of having ADHD. As an integral part of everyday language, the diagnosis is drawn upon as a resource and an active component in prisoners’ identity work, in which stigma and deviations are construed as disease that is treatable using legal drugs rather than illegal drugs. The ADHD diagnosis provides professionals with a specific understanding of the challenges they face in their client-related work, since the ADHD diagnosis displaces problematic behavior from being a question of morality or law to a question of mental illness. Finally, the findings are related to Nikolas Rose’s theories about the politics of life and biologization and how the distinction between normality and pathology can be blurred.
Differentiated models of care for postpartum women on antiretroviral therapy in Cape Town, South Africa: a cohort study
Authors: Myer Landon , Iyun Victoria , Zerbe Allison , Phillips Tamsin K. , Brittain Kirsty , Mukonda Elton , Allerton Joanna , Kalombo Cathy D. , Nofemela Andile , Abrams Elaine J.
Published: July 2017

Background: The numbers of women initiating lifelong antiretroviral therapy (ART) during pregnancy and postpartum is increasing rapidly, presenting a burden on health systems and an urgent need for scalable models of care for this population. In a pilot project, we referred postpartum women who initiated ART during pregnancy to a community‐based model of differentiated ART services.

Methods: Eligible women (on ART for at least 3 months with viral load (VL)<1000 copies/mL) were offered a choice of two ART models of care: (i) referral to an existing system of community‐based ‘adherence clubs’, operated by lay counsellors with medication collection every 2–4 months; or (ii) referral to local primary healthcare clinics (PHC) with services provided by clinicians and medication collection every 1–2 months (local standard of care for postpartum ART). For evaluation, women were followed through 6‐months postpartum with VL testing separate from either ART service.

Results: Through September 2015, n = 129 women were enrolled (median age, 28 years; median time postpartum, 10 days). Overall, 65% (n = 84) chose adherence clubs and 35% (n = 45) chose PHCs; there were no demographic or clinical predictors of this choice. Location of service delivery was commonly cited as a reason for choice by women selecting either model of care; shorter waiting times, ability to receive ART from lay counsellors and less frequent appointments were motivations for choosing adherence clubs. Among women choosing adherence clubs, 15% never attended the service and another 11% attended the service but were not retained through six months postpartum. Overall, 86% of women (n = 111) remained in the evaluation through 6 months postpartum; in this group, there were no differences in VL<1000 copies/mL at six months postpartum between women choosing PHCs (88%) vs. adherence clubs (92%; p = 0.483), but women who were not retained in adherence clubs were more likely to have VL≥1000 copies/mL compared to those who remained (p = 0.002).

Discussion: Adherence clubs may be a valuable model for postpartum women initiating ART in pregnancy, with good short‐term outcomes observed during this critical period. To support optimal implementation, further research is needed into patient preferences for models of care, with consideration of integration of maternal and child health services, while ART adherence and retention require ongoing consideration in this population.
Telling Active Learning Pedagogies Apart: from theory to practice
Authors: Hood Cattaneo Kelsey
Published: July 2017

Designing learning environments to incorporate active learning pedagogies is difficult as definitions are often contested and intertwined. This article seeks to determine whether classification of active learning pedagogies (i.e., project-based, problem-based, inquiry-based, case-based, and discovery-based), through theoretical and practical lenses, could function as a useful tool for researchers and practitioners in comparing pedagogies. This article classified five active learning pedagogies based on six constructivist elements. The comparison was completed through a comparative analysis and a content analysis informed by a systematic literature review. The findings were that learner-centeredness is a primary goal of all pedagogies; however, there is a strong dissonance between each pedagogy’s theoretical underpinnings and implementation realities. This dissonance complicates differentiating active learning pedagogies and classification as a comparative tool has proved to have limited usefulness.
Reply to comment by Z. Yi et al. on “Remagnetization of the Paleogene Tibetan Himalayan carbonate rocks in the Gamba area: Implications for reconstructing the lower plate in the India‐Asia collision”
Authors: Huang Wentao , Lippert Peter C. , Jackson Michael J. , Dekkers Mark J. , Zhang Yang , Li Juan , Guo Zhaojie , Kapp Paul , van Hinsbergen Douwe J. J.
Published: July 2017

In their comment on our publications on pervasive remagnetization of Jurassic‐Paleogene carbonate rocks of the Tibetan Himalaya (Huang et al., 2017, Journal of Geophysical Research: Solid Earth, 122, doi: 10.1002/2016JB013662 and 122, doi: 10.1002/2017JB013987), Yi et al. (2017) questioned our fold tests applied to their published paleomagenetic results from the Paleogene Zongpu and latest Cretaceous Zongshan carbonate rocks (Patzelt et al., 1996, Tectonophysics, 259(4), 259–284; Yi et al., 2011, Earth and Planetary Science Letters, 309(1), 153–165). They argued that authigenic magnetite pseudomorphic after pyrite, which is the dominant magnetic carrier within these carbonate rocks as indicated by our thorough rock magnetic and petrographic investigations, was formed during early diagenesis and that the primary natural remanent magnetization (NRM) is retained by these carbonate rocks. However, their statement for the invalidity of our fold tests is based on unrealistic assumptions that these carbonate rocks carry primary NRM and that the upper Zongpu Formation was deposited on a 10° primary dip. Their argument for immediate oxidization of pyrite to authigenic magnetite after carbonate deposition onto the continental passive margin ignores that sulfate‐reducing conditions were prevailing during early diagenesis, it is also inconsistent with the timing of the secondary remanence acquisition in remagnetized carbonate rocks elsewhere. As previously demonstrated, and agreed upon by Yi et al. (2017), the Zongpu and Zongshan carbonate rocks in Gamba are remagnetized; here we argue that the timing of remagnetization cannot be demonstrated to shortly postdate sedimentation. These data should therefore not be used for tectonic reconstructions.
Ackermann, Rudolph
Authors: Harris Katherine D.
Published: July 2017

Rudolph Ackermann (1764–1834) – print‐seller, bookseller, publisher, inventor, businessman – popularized aquatint, lithography, and illustrated books from his vast London publishing house, R. Ackermann, and the Repository of Arts shop. Allen M. Samuels (1974) suggests that this savvy, German‐born entrepreneur can only be qualified by the business records that he left behind. Without a centralized archive of his letters, we can only surmise the accuracy of a
Notes and Queries
article's (1869) description: ‘To the end of his days he retained a strongly marked German pronunciation of the English language, which gave additional flavor to the banters and jests uttered in his fine bass voice; but he wrote in English with great purity on matters of affection and of business long before middle life’ (130). Many publishers, artists, and authors, including Alaric A. Watts, John Clare, J.B. Papworth, John Murray, James Hogg, William Jerdan, Sir Walter Scott, J.M.W Turner, William Combe, Thomas Rowlandson, and Thomas Hood, refer to Ackermann in their memoirs and letters, but only as it pertains to his business acumen. Very few accounts exist of Ackermann's workplace, with the exception of a single 1798 mention by colourist John Sell Cotman, and that provided by his son, Miles Edmund. John Ford, Ackermann's only biographer, paints a picture of a well‐liked humanitarian (1983). Ackermann built a successful business on innovative printing technology and capitalized on current movements in politics and culture but never seemed to personally subscribe to political views himself. Doubtless Ackermann was instrumental to London's publishing history especially the advancement of illustrated books, but Ford's portrait of a benevolent businessman has been explored more deeply in recent scholarly articles – though an updated full biography of Rudolph Ackermann has yet to be written.
Anglo‐Jewish Prose
Authors: Spector Sheila A.
Published: July 2017

Most studies of Anglo‐Jewish prose begin in the Victorian era; certainly, starting in the 1830s, there were far more publications written by self‐identified Jews, dealing with specifically Jewish topics. However, a survey of prose published between the 1780s and 1830s suggests the consolidation of a distinctly English voice, one that laid the foundation for later Anglo‐Jewish culture. In contrast to Jews on the Continent, those in England had not developed a strong rabbinic tradition; and although they suffered legal disabilities, they were generally better off than their European counterparts. As a result, when other Western Jews were arguing over the merits of modernization, English Jews, with some notable exceptions, bypassed the dispute, creating an amalgamation that blended together the traditionalism of their ethnicity and the modernity of nationalism, as part of the process by which they anglicized Judaism. Specifically, they reclaimed the religious literature that had been co‐opted by the majority culture, and in the process, they re‐presented it in a form that could appeal to both the Jewish and Christian communities. During the same period, secular writers infused English literature with a kind of Jewish sensibility that affected the development of British national literature.