bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-term, Real-life, Observational Study in Treating Outpatient Ulcerative Colitis with Golimumab
Authors: Tursi Antonio , Mocci Giammarco , Elisei Walter , Allegretta Leonardo , Colucci Raffaele , Della Valle Nicola , De Medici Antonio , Faggiani Roberto , Ferronato Antonio , Forti Giacomo , Larussa Tiziana , Lorenzetti Roberto , Luzza Francesco , Penna Antonio , Pranzo Giuseppe , Rodinò Stefano , Sacco Rodolfo , Sebkova Ladislava , Zampaletta Costantino , Graziosi Camilla , Picchio Marcello , Bergna Irene Maria Bambina , Maconi Giovanni
Published: November 2021

Background and Aims: Several studies have found Golimumab (GOL) effective and safe in the short-term treatment of ulcerative colitis (UC), but few long-term data are currently available from real world. Our aim was to assess the long-term real-life efficacy and safety of GOL in managing UC outpatients in Italy.

Methods: A retrospective multicenter study assessing consecutive UC outpatients treated with GOL for at least 3-month of follow-up was made. Primary endpoints were the induction and maintenance of remission in UC, defined as Mayo score ≤2. Several secondary endpoints, including clinical response, colectomy rate, steroid free remission and mucosal healing, were also assessed during the follow-up.

Results: One hundred and seventy-eight patients were enrolled and followed up for a median (IQR) time of 9 (3-18) months (mean time follow-up: 33.1±13 months). Clinical remission was achieved in 57 (32.1%) patients: these patients continued with GOL, but only 6 patients (3.4%) were still under clinical remission with GOL at the 42nd month of follow-up. Clinical response occurred in 64 (36.4%) patients; colectomy was performed in 8 (7.8%) patients, all of them having primary failure. Steroid-free remission occurred in 23 (12.9%) patients, and mucosal healing was achieved in 29/89 (32.6%) patients. Adverse events occurred in 14 (7.9%) patients.

Conclusions: Golimumab does not seem able to maintain long-term remission in UC in real life. The safety profile was good.
Doping limits in p-type oxide semiconductors
Authors: Robertson John , Zhang Zhaofu
Published: November 2021

The ability to dope a semiconductor depends on whether the Fermi level can be moved into its valence or conduction bands, on an energy scale referred to the vacuum level. For oxides, there are various suitable n-type oxide semiconductors, but there is a marked absence of similarly suitable p-type oxides. This problem is of interest not only for thin-film transistors for displays, or solar cell electrodes, but also for back-end-of-line devices for the semiconductor industry. This has led to a wide-ranging search for p-type oxides using high-throughput calculations. We note that some proposed p-type metal oxides have cation s-like lone pair states. The defect energies of some of these oxides were calculated in detail. The example SnTa2O6 is of interest, but others have structures more closely based on perovskite structure and are found to have more n-type than p-type character.

Graphic abstract
Assessment of the state of personal and situational anxiety and indicators of stress-implementing and stress-limiting systems of the organism as marker efficiency the antenatal preparation
Authors:   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Skripchenko N.Y. , Nevyshna Y.V. ,   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv
Published: November 2021

As a result of research conducted on the basis of the State Institution «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova NAMS of Ukraine», the issue of the transcranial electrostimulation introduction in preparation for partnership labor was shown. Purpose — to study the features of changes in the state of personal and situational anxiety, stress-implementing and stress-limiting systems of the body in healthy women depending on the method of prenatal training. Materials and methods. 120 somatically healthy women without severe extragenital and obstetric pathology with a physiological course of singleton pregnancy were examined. In the first group — 45 women set up for partner childbirth, the second group also included 45 patients who underwent a course of transcranial electrical stimulation (TES) of mesodiencephalic structures of the brain in comprehensive preparation for partner childbirth. The control group included 30 women who did not receive prenatal training, did not have individual support in childbirth and were tuned to traditional methods of pain relief as needed. Results. Following the results of the determination of pain rate in the dynamic of the TES procedure, a progressive growth of the pain tolerance threshold was recorded with the subsequent stabilization of this value after the 5th procedure of electrical stimulation. Methods of psychophysical preparation for childbirth using transcranial electrostimulation and partner support made it possible to reduce medical induced pain relief during childbirth, which is what the data we obtained indicate. Conclusions. The use of TES in complex prenatal preparation for partner labor allows to achieve and maintain a stable psycho-emotional adaptation of pregnant women and increases the tolerance of the consonant to labor pain without additional medication load, which helps to make more physiological course of labor. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: labor, prenatal preparation, transcranial electrostimulation, pain threshold, anesthesia, partnership labor.
Concentration of 25(OH)D in blood serum and certain aspects of the clinical course of juvenile scleroderma
Authors:   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Omelchenko L.I. , Mukvich O.M. ,   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Ismakaeva D.L. ,   SI Institute of Pediatrics of Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine, Kyiv, Belskaya O.A. ,   SI Institute of Pediatrics of Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine, Kyiv, Ludvik T.A. ,   SI Institute of Pediatrics of Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine, Kyiv
Published: November 2021

Purpose — to assess the vitamin D supply in children and adolescents with systemic juvenile scleroderma (JS), taking into account its onset and clinical course at different periods of the child's development. Materials and methods. 14 children of 1 year 3 months —17 years old with systemic JS and 10 healthy children of the control group were examined. The concentration of 25(OH)D was determined in blood serum using commercial kits Vitamin D3 — Screeningkit, Switzerland, according to the manufacturer's instructions. Results. All patients with systemic JS showed a decrease in serum 25(OH)D levels — (24.55±9.32) ng/ml, compared to healthy children — (39.98±3.11) ng/ml. The lowest concentrations of the circulating form of vitamin D in the blood serum were in patients with limited form of systemic JS with Parry–Romberg hemiatrophy and «saber strike» — (14.07±3.38) ng/ml, as well as with the onset of generalized rapidly progressive JS in children at puberty — (16.31±4.6) ng/ml. Conclusions. Children with JS are shown to assess their vitamin D status by monitoring the serum concentration of 25(OH)D in order to decide whether to prescribe vitamin D supplements. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: children, juvenile scleroderma, vitamin D.
Modern approaches for perinatal management in thrombocytopenia during pregnancy
Authors:   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Naumchik О.М. , Davydova Iu.V. ,   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Limanska A.Yu. ,   SI Institute of Pediatrics of Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine, Kyiv
Published: November 2021

The most common diseases of the blood system in pregnant women are anemia and thrombocytopenia (TP). There is a general tendency to significantly reducing of the number of platelets during pregnancy, starting from the first trimester with a minimum number of them during childbirth. Purpose — to learn the features of motion of pregnancy, diagnostic and curative tactician at the thrombocytopenia during pregnancy. The causes of TP during pregnancy are three groups of conditions — conditions for which TP is characteristic outside of pregnancy and conditions associated with pregnancy: gestational thrombocytopenia (GTP), pregnancy-specific complications, manifestations of diseases characterized by TP, with the chief reason among them — immune thrombocytopenia (ITP). The most common cause of TP during pregnancy is GTP, which, like ITP, is diagnose of exclusion that require differential diagnosis. The goal of treating TP during pregnancy is to achieve a safe platelet count that is different for each trimester, not target values. If the treatment of ITP is need lines of therapy with control of efficiency are consistently applied. Pregnant women with moderate and severe TP are a group of high perinatal risk, requiring careful differential diagnosis of the causes of TP, calculation of maternal and fetal risks, choice of tactics of such pregnancy, method and time of delivery, formation of postnatal care plan. No conflict of interest was declared by the authors. Key words: pregnancy, thrombocytopenia, immune thrombocytopenia, gestational thromocytopenia.
Wartość gospodarcza okrywy roślinnej gleby w aspekcie nawożenia oraz zdolności retencyjnej płytki gleby górskiej
Authors:   University of Agriculture in Krakow, Kacorzyk Piotr
Published: November 2021

The aim of the study was to assess the impact of method management of mountain soil on the quantity and quality of waste water, and the amount of mineral nutrients it contains. I have analyzed the water, that was moved through the soil profiles of 0-20 cm and 0-40 cm depth. I have also evaluated the floristic composition, the productivity of grassland and arable land, and the use of fertilizers by vegetation and soil chemical properties. I have found that the type of plant cover of the soil had a significant effect on the amount and chemical composition of water moving through the soil profile. Arable land was characterized by an average of 5 percentage point higher drainage rates compared to meadows. The smallest outflow of water from the soil was found in the first research period (intensive vegetation), and the largest in the third period (non-vegetation). The largest amount of the mineral content carried out annually with a soaking water, was observed on the arable land and was on average more than 2 times larger than on other fertilizers. This evidenced by the greater variation in the composition of floristic vegetation and its productivity. Between 0-20 cm and 0-40 cm of soil profiles, significant differences in the amount of waste water and mineral components were observed. The water drainage coefficient from the shallow profile was on average 9 percentage points higher than from the deeper profile. The amount of the sum of mineral loads, excluding calcium from the shallow soil profile was 94,5% higher than the sum of loads taken from the deeper soil profile. In the unused meadow the improvement of soil chemical properties was observed. There was an increase in pH, and the accumulation of minerals resulted from the positive balance of most of the ingredients.
Associations of motor neuron disease research productivity and socioeconomic factors in Southeast Asia: a bibliometric analysis
Authors: Turalde Christian Wilson Rosales , Espiritu Adrian Isidoro , Jamora Roland Dominic Go
Published: November 2021

ABSTRACT Background: Scientific productivity on motor neuron disease (MND) research has been hypothesized to be low in Southeast Asia (SEA). Objective: To investigate the scientific productivity of SEA countries on MND and the associations between research metric indices and various country-specific socioeconomic parameters. Methods: We searched electronic databases for relevant articles from SEA on MND from the earliest indexed record to June 30, 2020. We obtained the following research productivity indices: bibliometric (number of publications in journals with impact factor (IF) and Scopus citations) and altmetric indices (PlumX metrics). We also collected data from published literature and reliable sources on the following socioeconomic variables: population, gross domestic product (GDP), GDP per capita, %GDP allocated for research and development (R&D) and the number of neurologists per country. Results: We included 196 articles that satisfied our inclusion criteria. Amyotrophic lateral sclerosis studies comprised the majority of the articles (n = 112; 57.1%). The top three countries in terms of the numbers of publications in journals with IF and in PlumX metrics were Singapore (n = 129), Malaysia (n = 26), and Thailand (n = 18). GDP per capita, %GDP for R&D and number of neurologists per one million population had strong positive correlations with the bibliometric and altmetric indices. Conclusions: This study highlights that although the scientific productivity of MND research in SEA has been low, it is continuously growing. This also emphasizes the imperative to improve economic indices and the number of neurologists in SEA to enhance scientific output on MND.
Evaluation of subjective vertical perception among stroke patients: a systematic review
Authors: Ferreira Luana Ribeiro , Ferreira Flávio José Pereira De Almeida , Campos Fernanda Aparecida , Luvizutto Gustavo José , Souza Luciane Aparecida Pascucci Sande De
Published: November 2021

Abstract Background: Verticality misperception is relatively common among patients after stroke, and it may be evaluated in terms of (a) subjective visual vertical (SVV), (b) subjective haptic vertical (SHV) and (c) subjective postural vertical (SPV). To better understand these assessment methods, we conducted a systematic review of the methodological characteristics of different protocols for evaluating SVV, SHV and SPV among individuals after stroke. Objective: To standardize the methodological characteristics of protocols for evaluating verticality perception after stroke. Methods: We searched the following databases: PUBMED, regional BVS portal (MEDLINE, LILACS, IBECS, CUBMED, Psychology Index and LIS), CINAHL, SCOPUS, Web of Science, Science Direct, Cochrane Library and PEDro. Two review authors independently used the QUADAS method (Quality Assessment of Diagnostic Accuracy Studies) and extracted data. Results: We included 21 studies in the review: most (80.9%) used SVV, eight (38.1%) used SPV and four (19.0%) used SHV. We observed high variability in assessments of verticality perception, due to patient positions, devices used, numbers of repetitions and angle of inclination for starting the tests. Conclusion: This systematic review was one of the first to explore all the methods of assessing verticality perception after stroke, and it provides crucial information on how to perform the tests, in order to guide future researchers/clinicians.
Acetylsalicylic acid (Aspirin®) and liver regeneration: experimental study in rats
Authors: BIONDO-SIMÕES MARIA DE LOURDES PESSOLE , PESSINI VICTOR CEZAR DE AZEVEDO , ICHI CAROLINA AYUMI , ROBES ROGÉRIO RIBEIRO , IOSHII SÉRGIO
Published: November 2021

ABSTRACT Objective: to evaluate the influence of acetylsalicylic acid (ASA) on cell proliferation after partial hepatectomy in rats. Methods: 40 male Wistar rats were separated into four groups of ten rats each. Groups 1 and 2 (controls): undergoing 30% partial hepatectomy and, after one day (group 1) and seven days (group 2), to euthanasia; daily administration of 0.9% saline solution (1mL per 200g of body weight). Groups 3 and 4 (experimental): undergoing 30% partial hepatectomy and, after one day (group 3) and seven days (group 4), to euthanasia; daily administration of ASA (40mg/mL, 1mL per 200g of body weight). The absolute number of cells stained with PCNA was counted in photomicrographs, in five fields, and it was calculated the mean of positive cells per animal and per group. Results: the final mean of PCNA+ cells per group was: in group 1, 17.57 ± 6.77; in group 2, 19.31 ± 5.30; in group 3, 27.46 ± 11.55; and, in group 4, 12.40 ± 5.23. There was no significant difference at the two evaluation times in the control group (p=0.491), but there was in the experimental group (p=0.020), with a lower number of PCNA+ cells on the seventh day. The comparison between the two groups, on the first day, showed more PCNA+ cells in the livers of the animals that received ASA (p=0.047), and on the seventh day the number was lower in the experimental group (p=0.007). Conclusion: ASA induced greater hepatocyte proliferation.
Avaliação da exposição a BTEX em postos de revenda de combustíveis no Rio de Janeiro, Brasil, e os riscos à saúde do trabalhador
Authors: Figueiredo Victor Oliva , Carvalho Leandro Vargas Barreto de , Borges Renato Marçullo , Costa-Amaral Isabele Campos , Santos Marcus Vinicius Corrêa dos , Rosa Ana Cristina Simões , Menezes Marco Antônio Carneiro de , Mattos Rita de Cássia Oliveira da Costa , Sarcinelli Paula Novaes , Alves Sergio Rabello , Larentis Ariane Leites , Gonçalves Eline Simões
Published: November 2021

A gasolina é uma mistura complexa de substâncias, dentre elas estão hidrocarbonetos como o benzeno, tolueno, etilbenzeno e xilenos (BTEX), sendo esses compostos emitidos para a atmosfera, com destaque ao benzeno, por ser comprovadamente carcinogênico. Objetivamos avaliar as concentrações de BTEX no ar de postos de revenda de combustíveis no Município do Rio de Janeiro, Brasil, e calcular o risco de câncer associado a estas exposições. Foram realizados dois tipos de amostragem (fixa e móvel) adaptadas da metodologia nº 1.501 do Instituto Nacional de Segurança e Saúde Ocupacional (Estados Unidos), em seis postos de revenda de combustíveis na Zona Oeste da cidade. A amostragem fixa foi feita próxima às bombas de combustível, enquanto a móvel foi realizada através da coleta do ar na zona respiratória dos trabalhadores (frentistas), conforme estes se deslocavam pelo posto. As amostras foram analisadas por cromatografia gasosa com detecção por ionização em chama. Com os resultados das amostragens foram feitos os cálculos de risco à saúde, usando os indicadores Quociente de perigo (HQ) e Risco de câncer (CR), para avaliar os possíveis efeitos não-carcinogênicos e carcinogênicos, respectivamente, nos trabalhadores dos postos de revenda de combustíveis. As concentrações ambientais para a maioria dos compostos BTEX foram abaixo dos limites preconizados, menos para o benzeno, um composto carcinogênico, que apresentou concentrações muito acima dos limites, levando a altos valores de risco de câncer. Os resultados demonstraram que há riscos à saúde dos trabalhadores de postos de revenda de combustíveis, principalmente o risco de desenvolver câncer, devido à exposição excessiva ao benzeno.
Dietary supplementation of Agaricus bisporus stalk meal on growth performance, carcass and organ traits, meat quality, cecum mesophilic aerobic bacteria counts and intestinal histology in broiler chickens
Authors: Altop Aydin , Coskun Isa , Filik Ayse Gul , Cayan Huseyin , Sahin Ahmet , Gungor Emrah , Erener Guray
Published: November 2021

ABSTRACT: Effects of dietary Agaricus bisporus mixture or stalk or cap on growth performance, carcass components and some meat quality parameters, mesophilic aerobic bacterial counts, and intestinal histomorphology in broiler chickens were investigated. Two hundred and forty one-day-old male Ross 308 broiler chickens were divided into 4 experimental groups with 4 replicates, each including 15 birds. Chickens were fed with basal diet (C), mushroom mixture (MM, 10 g stalk+10 g cap/kg diet), mushroom stalk (MS, 20 g/kg diet) and mushroom cap (MC, 20 g/kg diet). Feed conversion ratio (FCR) was improved (P < 0.01) by dietary MS while feed intake (FI) decreased (P < 0.01) in all treatment groups compared to control. However, body weight gain (BWG) was decreased (P < 0.01) by MC inclusion. Mushroom supplemented groups had higher (P < 0.05) mesophilic aerobic bacteria in the cecum. MS inclusion increased villus height to crypt depth ratio in the jejunum (P < 0.01) and villus height in the ileum (P < 0.01) and jejunum (P < 0.05). MC increased (P < 0.01) crypt depth in the jejunum. There were no statistical differences among groups for carcass components (P > 0.05). The L* values were decreased (P < 0.01) in thigh meat but increased (P < 0.01) in breast meat by mushroom inclusion. The a* values were decreased (P < 0.01) and b* values were increased (P < 0.05) in both thigh and breast meat with mushroom addition to diet. The obtained results indicated that A. bisporus stalk meal at an inclusion level of 20 g/kg of diet had favourable effects on growth performance with higher feed efficiency, improved intestinal morphology with higher villus height and increased meat quality of broiler chickens.
Environmental degradation and agriculture: an approach in countries by middle of indexes
Authors: Pinto Nelson Guilherme Machado , Rossato Vanessa Piovesan , Müller Andressa Petry , Coronel Daniel Arruda
Published: November 2021

ABSTRACT: Society evolution is commonly followed by changes; however, some of them bring negative implications for the community. One of these consequences refers to environmental degradation, which has agricultural activity as one of its influencing agents, which is essentially characterized by man’s predatory actions. Accordingly, this research analyzed the environmental degradation in 167 pattern in the agricultural world. Therefore, the Agricultural Environmental Degradation Index (IDAA) was used as a proxy for agricultural environmental degradation and the factor analysis technique. Results indicated that the most degraded country was Russia, which belongs to the European continent; however, the other positions were occupied predominantly by Africa, followed by North America and Oceania. Issues such as rural poverty and primitive natural settings can leverage this phenomenon. The lowest rates of degradation were concentrated on Central America and Europe, where agricultural activity was most incipient. In this sense, a directly proportional relationship between environmental degradation and agricultural practice was reported considering that countries dependent on this phenomenon had the most worrying results. Thereby, there is an emerging need for public policies that integrate economic and environmental dimensions that reduce negative impacts in the regions most degraded.
A lettuce moisture detection method based on terahertz time-domain spectroscopy
Authors: Zhang Xiaodong , Duan Zhaohui , Mao Hanping , Gao Hongyan , Zuo Zhiyu
Published: November 2021

ABSTRACT: For non-destructive detection of water stress in lettuce, terahertz time-domain spectroscopy (THz-TDS) was used to quantitatively analyze water content in lettuce. Four gradient lettuce water contents were used . Spectral data of lettuce were collected by a THz-TDS system, and denoised using the S-G derivative, Savitzky-Golay (S-G) smoothing and normalization filtering. The fitting effect of the pretreatment method was better than that of regression fitting, and the S-G derivative fitting effect was obtained. Then a calibration set and a verification set were divided by the Kennan-Stone algorithm, sample set partitioning based on joint X-Y distance (SPXY) algorithm, and the random sampling (RS) algorithm, and the parameters of RS were optimized by regression fitting. The stability competitive adaptive reweighted sampling, iteratively retained information variables and interval combination optimization were used to select characteristic wavelengths, and then continuous projection was used on basis of the three algorithms above. After the successive projection algorithm was re-screened, partial least squares regression was used into modeling. The regression coefficients Rc 2 and RMSEC reach 0.8962 and 412.5% respectively, and Rp 2 and RMSEP of the verification set are 0.8757 and 528.9% respectively.
Inoculation methods and agressiveness of Macrophomina phaseolina isolates in cowpea
Authors: Souza Erik Micael da Silva , Silva Leonardo Aparecido Brandão da , Pinto Francisco Álef Carlos , Borel Jerônimo Constantino , Capucho Alexandre Sandri , Ishikawa Francine Hiromi
Published: November 2021

ABSTRACT: The fungi Macrophomina phaseolina is the charcoal rot causal agent, one of the most important cowpea crop disease in semiarid regions can causes 100% yield losses. The search for resistant genotypes requires efficient phenotyping. In addition, there is the problem of great variation in aggressiveness between isolates. This study aimed to 1) test three methods of inoculation in semiarid conditions, and 2) to evaluate the aggressiveness of isolates of M. phaseolina. In the first experiment carried out in greenhouse, the inoculations methods were evaluated, using two cowpea lines, three inoculation methods and three pathogen isolates. On the second experiment, fifteen M. phaseolina isolates were inoculated in one cultivar to evaluate their aggressiveness. By assessing the length of the lesions and the severity of the disease using an index, we identified the toothpick inoculation method as the most efficient. Toothpick method allowed to discriminate the genotypes and the aggressiveness of the pathogen.
Comparative analysis of brain in relation to the body length and weight of common carp (Cyprinus carpio) in captive (hatchery) and wild (river system) populations
Authors: Khan W. , Khan M. I. , Hussain S. , Masood Z. , Shadman M. , Baset A. , Rahman A. , Mohsin M. , Alfarraj S.
Published: November 2021

Abstract Cyprinus carpio is the member of family cyprinidae commonly called common carp. This study was aimed to find out the comparison of brain of wild (river system) and captive (hatchery reared) population of common carp. A total of thirty samples (15 from hatchery and 15 from river Swat) were collected. All the specimens were examined in Laboratory of Parasitoloy, Zoology Department, University of Malakand. Findings indicated that wild population were greater in brain size and weight as compared to hatchery reared population. The fish samples collected from captive environment (hatchery) were showing more weight and length as compared to wild population of common carps. The mean value of total weight of hatchery fishes 345±48.68 and the mean value of brain weight of hatchery reared fishes 0.28±0.047. The mean value of wild fish’s total body weight 195.16±52.58 and the mean value of brain weight of wild fishes are 0.45±0.14. Present research calls for the fact that fish in dependent environmental conditions possess brain larger in size as compared to its captive population, it is due to use and disuse of brain in their environmental requirements.
Investigation the effects of vitreous humor on proliferation and dedifferentiation of differentiated NTERA2 cells
Authors: Rezaeian Z. , Bahrami A. R. , Matin M. M. , Hosseiny S. S.
Published: November 2021

Abstract Mammals have a limited capacity to regenerate their tissues and organs. One of the mechanisms associated with natural regeneration is dedifferentiation. Several small molecules such as vitamin C and growth factors could improve reprogramming efficiency. In this study, the NTERA2-D1 (NT2) cells were induced towards differentiation (NT2-RA) with 10-5 M retinoic acid (RA) for three days and then subjected to various amounts of vitreous humor (VH). Results show that the growth rate of these cells was reduced, while this rate was partly restored upon treatment with VH (NT2-RA-VH). Cell cycle analysis with PI method also showed that the numbers of cells at the S phase of the cell cycle in these cells were increased. The levels of SSEA3 and TRA-1-81 antigens in NT2-RA were dropped but they increased in NT2- RA-VH to a level similar to the NT2 cells. The level of SSEA1 had an opposite pattern. Expression of OCT4 gene dropped after RA treatment, but it was recovered in NT2-RA-VH cells. In conclusion, we suggest VH as a potent mixture for improving the cellular reprogramming leading to dedifferentiation.
Rethinking the Course Content and Pedagogies used in Learning about 'Asian Religions'
Authors: Frahm-Arp Maria
Published: November 2021

This essay examines the concerns expressed by students when studying a second-year module on Asian religions and how they thought the facilitation of their learning could be most effective. Following research done with three cohorts of second-year students studying Asian religions from 2015 to 2017, this essay argues that both changes in pedagogy and course content are needed to create spaces where learning about these religions can address the concerns raised by students. Students were particularly concerned about how studying Asian religions would prepare them for the world of work and the Fourth Industrial Revolution. The research for this essay is located in a social constructivist pedagogy that forefronts social justice and is grounded in an engaged learning practice. The essay examines why in the Fourth Industrial Revolution, studying Asian religions is important and valuable to students studying for a degree in preparation for entry into the workplace. The essay shows that engagement with different technologies in teaching and learning enables a pedagogy of co-knowledge production and co-sharing of knowledge where students learn technological skills, critical thinking skills, and a deepening awareness of their worldviews and those of other people. In so doing, this module addressed student concerns about their studies and the skills they considered valuable in preparing them for future careers.
Regulation of peyote (Lophophora williamsii: Cactaceae) in the U.S.A: A historical victory of religion and politics over science and medicine
Authors: Terry Martin , Trout Keeper
Published: November 2021

The peyote cactus, Lophophora williamsii, is presently classified as a Schedule 1 Controlled Substance in the USA, with an exemption for use as a sacrament in bona fide religious ceremonies of the Native American Church (NAC). Any botanist or other researcher seeking to work with peyote or any of its alkaloids, must com-ply with applicable (nontrivial) regulatory requirements. This paper presents an examination of the prohibition efforts that paved the way for current peyote regulation, accompanied by documentation of the religion-based political origins of such efforts, which involved the "acculturation" of Native Americans (i.e., the destruction of American Indian cultures). We also look at the historical emergence of a nationally organized and coordinated effort by missionaries and other prohibitionists to sell a federal anti-peyote law to Congress, which manifested itself repeatedly over a period of more than fifty years, before finally realizing success in the Controlled Substances Act of 1970. In view of ongoing changes in the legal/regulatory status of Cannabis sp. (another Schedule 1 plant that was targeted for illegality during the prohibitionists' rise to political predominance), we compare and contrast the two plants with speculation on peyote’s future.
Stephen Douglas Koch Olt (16 December 1940–14 January 2017)
Authors: Gómez-Sanchez Maricela , Kohashi Shibata Josué , Vibrans Heike
Published: November 2021

Stephen Douglas Koch Olt (16 December 1940–14 January 2017)
Nymphoides humboldtiana (Menyanthaceae) in Florida (U.S.A.) verified by DNA data
Authors: Middleton Beth A. , Anemaet Evelyn , Quirk Tracy Elsey , Tippery Nicholas P.
Published: November 2021

Certain Nymphoides populations in Florida, U.S.A., previously identified as the non-native N. indica (L.) Kuntze, are actually N. humboldtiana (Kunth) Kuntze, as verified using nuclear and plastid DNA data. These new records of N. humboldtiana in Florida are the only known localities in the U.S.A. outside of Uvalde County, Texas. Nymphoides humboldtiana is native to Texas, México, the Caribbean, and Central and South America. The newly identified Florida populations found near the city of Tampa in Manatee County (Ward Lake and Braden River) and Fort Walton Beach in Okaloosa County (Bass Lake) are presumed to be native. Nymphoides humboldtiana and N. indica share many superficial similarities, most notably white petals with ciliate hairs. Our findings suggest that certain morphologically-determined populations of N. indica in the U.S.A. may be incorrectly identified. Such populations might be re-examined using DNA methods to avoid any management actions against N. humboldtiana.
Arctium minus (Asteraceae): historical review, ecological consequences, and addition to Texas flora
Authors: Mink Jeffrey N. , Holmes Walter C. , Singhurst Jason R. , Treuer-Kuehn Amie
Published: November 2021

Arctium minus, a European native, is currently known to have been introduced throughout most of continental United States except for Florida, Delaware, and Texas. The species is reported in Texas in the Flora of North America, but without specimen documentation. Numerous historical nomenclature complexities and confusion involved in proper documentation of this species’ spread and distribution are discussed. It is here reported as new to Texas, based upon a collection in Oldham County in the northern Panhandle. The species is considered to be weedy and may have the potential to be invasive in the High Plains and Rolling Plains regions of Texas. Brief descriptions of historic distribution and spread based on early botanical literature, and various economic and ecological associations of A. minus are summarized.
Studies in the vascular flora of the southeastern United States: V
Authors: Weakley Alan S. , Schoonover McClelland R. Kevan , LeBlond Richard J. , Bradley Keith A. , Matthews James F. , Anderson Chad , Franck Alan R. , Lange James
Published: November 2021

As part of ongoing efforts to understand and document the flora of the southeastern United States, we propose a number of taxonomic changes. In Trichostema, we name a new species, narrowly endemic to maritime grasslands in the Carolinas and warranting formal conservation status and action. In Dichanthelium (Poaceae), we continue the reassessment of taxa formerly recognized in Panicum and provide new combinations along with a new key to taxa in the Dichanthelium scabriusculum complex. In Paspalum (Poaceae), we address the controversial taxonomy of P. arundinaceum and P. pleostachyum and treat the two as conspecific, with P. arundinaceum the correct name. In Portulaca (Portulacaceae), we report the discovery of the Bahamian P. minuta as a native component of the North American flora, occurring in southern Florida.
Strombothelya gen. nov., a fossil angiosperm with two species in mid-Cretaceous Myanmar amber
Authors: Poinar, Jr. George O. , Chambers Kenton L.
Published: November 2021

Strombothelya, a new genus of fossil angiosperms from Myanmar amber deposits, is represented by 2 flowers that are here described as separate species. Flowers of Strombothelya have 5 spreading, more or less distinctly veined sepals. Petals are absent. There are 10 inwardly arching stamens and a half-inferior ovary, whose broadly conic superior portion terminates in 1 or 3 stout, columnar, apically truncate styles. The superior portion has a papillate surface that was probably nectarifer-ous. The inferior portion of the ovary in both species is obconic and 5- or 10-ribbed. The fossils are comparable in certain respects to the genus Tropidogyne, described earlier from the same amber deposits. The 3 species of Tropidogyne have flowers with 5 or 10 stamens and 2 or 3 slender, curved, acutely-tipped styles. The inferior portion of the ovary is strongly 10-ribbed, while the superior portion is flat or cushion-shaped and bears a lobed nectar-disc. Strombothelya and Tropidogyne inhabited a Cretaceous araucarian rainforest, which may have been located in the Southern Hemisphere continent of Gondwana.
Zygadelphus aetheus gen. et sp. nov., an unusual fossil flower from mid-Cretaceous Myanmar amber
Authors: Poinar, Jr. George O. , Chambers Kenton L.
Published: November 2021

The flower described here as Zygadelphus aetheus gen. et sp. nov. was obtained from amber mines in Myanmar, preserved in marine sedimentary deposits dating to the mid-Cretaceous Period, ca. 99 My in age. The perianth consists of ca. 10 spirally arranged tepals that vary in size and shape. The stigmatic tips of two styles are visible, the remainder of the gynoecium being hidden from view by the crowding of stamens and perianth parts toward the center of the flower. There is a whorl of 4 stamens, the anthers of which have the feature, probably unique among angiosperms, of possessing a small but complete accessory stamen arising as an appendage on their dorsal surface. Anthers of both types of stamens are bilocular and dehisce by dorsally hinged valves. Presence of pollen in the accessory anthers indicates that they functioned in reproduction. Under the assumption that the fossil is not merely a teratological mutant in an otherwise normal-flowered species, it is here given taxonomic status as representing a peculiar type of floral development, now extinct, that existed during an earlier stage of angiosperm evolution.
What are the "sticky rings" on stems of Anulocaulis and related taxa (Nyctaginaceae) from arid regions?
Authors: Lopes da Cunha Neto Israel , Angyalossy Veronica , Douglas Norman A.
Published: November 2021

Anulocaulis, commonly known as “ringstem,” is a small, unusual genus restricted to the Chihuahuan, Sonoran, and Mojave deserts of North America. Here we combined light microscopy and histochemical tests to characterize for the first time the “sticky structures” (here called secretory rings) found on the stem internodes of Anulocaulis. The secretory rings were shown to be groups of epidermal cells, or unicellular glandular trichomes, which largely differ from their neighboring cells both in structure and histochemistry. The cells start to differentiate in early stages of stem development. They begin as regular epidermal cells, but later their anticlinal and external tangential walls start to enlarge. At maturity the cells become remarkably elongated, even balloon-like, with dense cytoplasmic content. Although the secretory rings have been reported as “mucilaginous structures” based on morphological observations, preliminary histochemical analyses showed that its exudate is complex, including a mixture of mucilage, proteins, and phenolic compounds. Future investigations are needed to compare the anatomy of the secretory rings within related genera of Nyctaginaceae and characterize the chemical components of their exudate more specifically to search for potential homologies and adaptive functions of these structures.
A comparison of efficacy of diclofenac patch and physical therapy techniques in the treatment of patients with myofascial pain disorder of the upper trapezius
Authors: Komal Razzaq , Umair Arif , Rabia Javaid , Hafiz Muhammad Almas Sabir , Attia Noreen , Maryam Ashfaq , Ramish Akram
Published: November 2021

Objective: This study was conducted to find the best treatment in treating the patients of myofascial syndrome for this purpose two treatment options were compared to rule out the best option of treatment in minimizing the pain, enhancing the cervical movement and in determining the pressure pain threshold of MTrp. Material and methodology: It was a comparative study. Total 60 patients were randomly allocated to each group of treatment. We compared two treatments, treatment A of 30 patients was physical therapy and 30 patients of treatment B was diclofenac patch. For seven days, these patches were applied three times per day to the MTrP area of the upper trapezius muscle. The fix’s sufficiency and security boundaries were evaluated before it was used (day 0), three days later (day 3), and six days later (day 6). Chi square test was used for checking association of treatments and different attributes of patients. Results: There is significance association was found between demographic characteristics and treatments groups with p-values less than 0.05. There is significance difference effect between both treatments using VAS pain scale and cervical active Rom and PPT of MTRP using p-value less 0.05. These results shows that physical therapy treatment effects are batter as compare to diclofenac patch. Conclusion: Physical therapy techniques and the diclofenac patch have both been shown to be helpful but significant results are shown by Group A in treating trigger points of upper trapezius by normalizing the pathophysiological reasons of trigger points of this region. Physical therapy techniques are more helpful in reducing pain and in achieving cervical movement.
[RETRACTED] Eagle Hemp CBD Gummies Shark Tank (Scam Or Legit 2021) Ingredients vs Side Effects Exposed Customer Review! v1
Authors: Hemp CBD Gummies Shark Tank Eagle
Published: November 2021

[RETRACTED]

Eagle Hemp CBD Gummies Shark Tank Cost is one such dietary enhancement. It is a characteristic healthful enhancement.
Monthly cleansing from the general pathological point of view
Authors: Kakushkin N.
Published: November 2021

The author looks at menstruation as a secretory process that exists for the liberation of the female body from unnecessary substances accumulating in the blood.
Influence of fetal death on albuminuria of a pregnant woman
Authors: Sheinis L.
Published: November 2021

A woman who had previously presented long-term tuberculosis suppuration of the right talus and the third metacarpi of the right hand, on the 5th month of pregnancy showed strong albuminuria and severe manifestations of uremic dysnea.
Intrauterine pregnancy; complete removal of the fetal mouse; gistѳrectomy by abdominal section; recovery
Authors: Sheinis L.
Published: November 2021

The patient, 30 years old, had a normal delivery ten years ago; the last menstruation was on January 10, 1896, and 4 months later she began to feel fetal movements, and nothing made me suspect an abnormal pregnancy.
Introduction to the course of obstetrics and gynecology in connection with clinical methods of teaching
Authors: Muratov A. A.
Published: November 2021

(Sep. Ott. From Uchenykh Zapiski of the Imperial Yuryev University, No. 2, 1898, Yuryev. 1898).In this introductory lecture, having remembered his predecessors in the department with a kind word, the author briefly touches on the history of the discovery of Semmelweiss and gives an outline of the modern meaning of antiseptics and aseptics in obstetrics. Clinical obstetric aid cannot yet, in the opinion of the author, do with one pure asepsis.
Modern methods for radiological diagnosis of endometriosis
Authors: Rusina Elena I. , Yarmolinskaya Maria I. , Ivanova Alina O.
Published: November 2021

Endometriosis is a widespread gynecological disease, which affects reproductive-aged women. An accurate diagnosis is critical to develop a more comprehensive treatment strategy for endometriosis than is currently available. This article provides an overview of current data on the value of radiation techniques for the diagnosis of external genital and extragenital endometriosis, deep infiltrating endometriosis, and adenomyosis. The necessity of using a systematic approach to examine the pelvis in women with suspected endometriosis is shown, modern terms and methods of measurement being given to describe ultrasound picture of endometriosis.
Obesity represents a strong pathogenetic link with the pathology of pregnancy and childbirth
Authors: Seryogina Darya S. , Nikolayenkov Igor P. , Kuzminykh Tatyana U.
Published: November 2021

Obesity is a significant health and social problem that is the scale of the growing worldwide epidemic. Over the past 10 years, the number of obese pregnant women has doubled. There are multiple risk factors associated with obesity, which includes poor nutrition, foods that are high in easily digestible carbohydrates and fats, frequent snacks, and widespread fast food consumption. Metabolic changes, especially in women with the genetic predisposition, are manifested by insulin resistance, hyperinsulinemia, arterial hypertension, and hypercoagulation syndrome. The course of pregnancy and childbirth in obese women is associated with a series of successive pathological conditions, such as miscarriage, the occurrence of gestational diabetes mellitus, preeclampsia and eclampsia, infectious complications, prolonged pregnancy, the occurrence of bleeding and much more. We have analyzed modern ideas about womens reproductive health and the course of pregnancy and childbirth in obesity.
Endometriosis at the present stage
Authors: Baskakov V. P.
Published: November 2021

In the lecture modern sights on ethiology and pathogenesis of endometriosis are represented. Problems of its conservative therapy are considered.
The evolution of methods of planning the family
Authors: Pilkevich R. P. , Gaivoronskih D. L.
Published: November 2021

... But can you explain who Persej or Jason irritates you?

And what do force to torment your womb by your hand?

In gloomy gorges Armenia the tigers are not so severe.

And impossible that the lion tried to pull out the fetus.

But the gentle girls only could attempt on it.

And their own death expects them as a punishment...

Ovidium.
Pathogenetic features of clinical current inflammatory diseases of internal genital organs on background intrauterine contraception (IUC)
Authors: Ivanova L. V. , Okisheva G. A. , Spodobets T. P.
Published: November 2021

Analysis of current inflammatory of uterus diseases and uterine appendages diseases was conducted at 1769 patients - age from 18-48 years. It is revealed, that the introduction IUC is responsible gynecological operation, requiring careful selection of woman with account of contraindicated, with observance of the rules aseptic and antiseptic subsequent strict regular medical check-up not less twice per year with vaginal bacteriological researching. The development of inflammatory process internal genital organs on a background IUC requires timely hospitalization, removal IUC and complex treatment as there is tendency, to spreading of infection for area of uterus and uterine appendages, that determines volume of surgical operation.
The psychosomatic approach to the obstetrical problems
Authors: Kaplun I. B.
Published: November 2021

In the review of the modern concepts of the psychosomatic frustration in the obstetrical practise is the given in present article.
The course of pregnancy, labor and postnatal stage of adolescent women
Authors: Susloparov L. A. , Ostrovskaya E. A. , Tatarovа N. A. , Dudnlchenko T. A.
Published: November 2021

The course of pregnancy delivery and postnatal stage of 466 adolescent women was analyzed. In fact every young pregnant, woman in childbirth and parturient had different complications: anemia (52 %), late gestosis (40 %), premature labor (32 %), intrauterine hypoxia (11 %) and fetal hypotrophia (7 %). The uterine and perineal ruptures often occurred (24%), abnormalities of labor activity (22 %), obstetric bleedings (17 %). The percentage of the delivery operations is high and the complicated postnatal stage too. The lower rate of the health of the adolescent mothers children occurred more often.The biological and psychological immaturity of the adolescent pregnants eyige to place them in the group of high risk in obstetric and perinatal pathology and to give them special recommendations in pregnancy and labor.