bluuebunny/crossref_metadata_2025 huggingface dataset:
In vitro anti-cancer and antimicrobial effects of manganese oxide nanoparticles synthesized using the Glycyrrhiza uralensis leaf extract on breast cancer cell lines
Authors: Althobiti Maryam Musleh , Alzahrani Badr , Elderdery Abozer Y. , Alzerwi Nasser A. N. , Rayzah Musaed , Elkhalifa Ahmed M. E. , Idrees Bandar , Bakhsh Ebtisam , Alabdulsalam Abdulrahim A. , Mohamedain A. , Kumar Suresh S. , Mok Pooi Ling
Published: September 2023

In this study, we evaluated the antiproliferative and apoptotic properties of Pluronic-F127-containing manganese oxide nanoparticles (PF-127-coated Mn2O3 NPs) derived from the leaf extract of Glycyrrhiza uralensis (GU) on breast adenocarcinoma, MCF7, and MDA-MB-231 cell lines. The leaf extract of GU contains bioactive molecules that act as a reducing or capping agent to form Mn2O3 NPs. Various analytical techniques were used to characterize the physiochemical properties of PF-127-coated Mn2O3 NPs, including spectroscopy (ultralight-Vis, Fourier transform infrared, photoluminescence), electron microscopy (field emission scanning electron microscopy and transmission electron microscopy), X-ray diffraction (XRD), electron diffracted X-ray spectroscopy (EDAX), and dynamic light scattering. The average crystallite size of Mn2O3 NPs was estimated to be 80 nm, and the NPs had a cubic crystalline structure. PF127-encapsulated Mn2O3 NPs significantly reduce MDA-MB-231 and MCF-7 cell proliferation, while increasing endogenous ROS and lowering mitochondrial matrix protein levels. DAPI, EtBr/AO dual staining, and Annexin-V-FITC-based flow cytometry analysis revealed that PF127-coated Mn2O3 NP-treated breast cancer cells exhibit nuclear damage and apoptotic cell death, resulting in cell cycle arrest in the S phase. Furthermore, PF127-encapsulated Mn2O3 NPs show strong antimicrobial efficacy against various strains. As a result, we can conclude that PF127-coated Mn2O3 NPs may be effective as future anticancer agents and treatment options for breast cancer.
Preparation of Pd/Ce(F)-MCM-48 catalysts and their catalytic performance of n-heptane isomerization
Authors: Cui Yanhong , Suo Yanhua , Zhang Wei , Wang Yingjun , Nie Chunhong , Wang Yanhong
Published: September 2023

Ce and F were added to MCM-48 molecular sieve by hydrothermal synthesis, and Pd/Ce(F)-MCM-48 metal acid bifunctional catalysts were prepared by impregnation method. The physical and chemical properties of Ce(F)-MCM-48 and Pd/Ce(F)-MCM-48 were characterized by X-ray diffraction, scanning electron microscope, NH3 temperature programmed desorption instrument, Fourier infrared spectrometer, and X-ray photoelectronic spectrometer characterization methods. The results showed that when the molar ratio of the raw materials was n(Ce):n(TEOS) = 0.02 and n(NaF):n(TEOS) = 0.10, Ce(F)-MCM-48-0.10 molecular sieve had a high degree of order and large specific surface area and pore volume, the total acid content increased, and the acid strength also increased. And it had an acidic center and generated certain oxygen vacancies. The catalyst prepared after Pd impregnation had good dispersibility. 0.4% Pd/Ce(F)-MCM-48-0.10 catalyst still maintained the crystalline phase of MCM-48 molecular sieve. A micro-reaction device was used to examine the catalytic performance of n-heptane isomerization of Pd/Ce(F)-MCM-48-0.10 catalysts. When the hydrogen flow rate was 30 mL·min−1, reduction temperature was 300°C, reduction time was 4 h, weight hourly space velocity was 7.6 h−1, and reaction temperature was 280°C, 0.4% Pd/Ce(F)-MCM-48-0.10 catalyst was used in the heptane isomerization reaction, where the conversion of n-heptane was 67.3% and the selectivity of isoheptane was 96.5%.
Impact of magnetic spinel ferrite content on the structure, morphology, optical, and magneto-dielectric properties of BaTiO3 materials
Authors: Slimani Yassine , Meena Sher Singh , Shirsath Sagar E. , Hannachi Essia , Almessiere Munirah A. , Baykal Abdulhadi , Sivakumar Rengasamy , Batoo Khalid M. , Thakur Atul , Ercan Ismail , Özçelik Bekir
Published: September 2023

In this study, the influence of magnetic content of NiFe1.93Dy0.07O4 spinel ferrite on the structural, morphological, optical, and magneto-dielectric properties of BaTiO3 materials was investigated. NiFe1.93Dy0.07O4 magnetic nanoparticles and BaTiO3 dielectric materials were firstly synthesized using the hydrothermal method and sol–gel auto-combustion route, respectively. Then, different contents of the magnetic nanoparticles were added to BaTiO3 to form a series of BaTiO3/(NiFe1.93Dy0.07O4)
x
samples (abbreviated as BTO/(NDFO)
x
) with x = 0, 2, 5, 10, 20, and 100 %. The analysis of the structure via X-ray diffraction (XRD) technique revealed a transformation from a tetragonal structure for the pristine BTO sample to a cubic structure upon the inclusion of magnetic nanoparticles. The morphological observations and chemical composition analyses via scanning electron microscope (SEM) coupled with EDX system showed the successful formulation of biphasic products. The optical properties were investigated, and it was found that the inclusion of the magnetic phase diminishes the bandgap energy (E

g
) of final BTO/(NDFO)
x
samples. Furthermore, vibrating sample magnetometer (VSM) was used to investigate the magnetization properties. The values of saturation magnetization (M

S
) and remanent (M

r
) magnetization are rising with the increase of magnetic phase content. However, the coercivity (H

c
) does not show a regular variation with the increase of NDFO content. The dielectric properties were also investigated for different BaTiO3/(NiFe1.93Dy0.07O4)
x
samples. The obtained results showed that the real permittivity (ε′) and dielectric tangent loss (tan δ) increased with increasing temperature. Remarkably, the addition of magnetic content provokes a reduction in tan δ values compared to the pristine BTO sample. The lowest values of tan δ and highest frequency stability were noticed in the sample added with 10 % of magnetic phase. The impedance and modulus were also determined and discussed.
Emlékház és galéria Budapest peremén
Authors: Frank Gabriella , Nemcsics Ákos
Published: September 2023

Nemcsics Antal és felesége, Takács Magda festőművész azt kívánta, hogy haláluk után a Ferihegyi repülőtér közelében lévő műteremházuk közösségi célokat, gazdag életművük és a kortárs képzőművészet kiemelkedő alkotóinak bemutatását szolgálja. Kívánságuknak megfelelően a hagyaték szakszerű megőrzését és hatékony bemutatását szem előtt tartva az örökösök – sok családon belüli és kívüli segítséggel – alig 10 hónap alatt kiállítóhellyé és a nagyközönség számára rendszeresen látogathatóvá tették a pestszentlőrinci Nemcsics házat, és ezzel 2020-ban a Nagykörúton túli Budapest fontos kulturális színterét hozták létre.

A Nemcsics Emlékház és Színország Galéria a 100 000 lakost számláló 18. kerület egyetlen magántulajdonú kulturális épülete, amely egyrészt eredeti helyszínen mutatja be a művész házaspár munkásságát, másrészt évente több - hasonló formanyelvet használó - kortárs művész időszaki kiállításával várja a látogatókat, illetve rendszeres múzeumpedagógiai foglalkozásokat és kutatási lehetőséget kínál az interdiszciplináris művészetek és a színelmélet iránt érdeklődőknek.

Ebben a rövid összefoglalásban majd három év tapasztalatai alapján azt kívánjuk „jó gyakorlatként” bemutatni, hogyan sikerült – nem kis munkával és összefogással – létrehozni Budapest peremén egy elismert, gazdag életművet őrző emlékházat és egyúttal a modern magyar képzőművészetet népszerűsítő galériát, illetve, hogy milyen nehéz egy ilyen „kulturális különlegességet” megfelelő intézményesített keretek és anyagi biztonság nélkül fenntartani.
Líceumi Lelécelés – Hogyan szökj meg Petőfivel Selmecbányáról?
Authors: Kondor Boglárka
Published: September 2023

Az Evangélikus Országos Múzeum ’A mi Sándorunk – Petőfi az evangélikus oktatás útvesztőiben’ című kiállításához kapcsolódó szabadulószoba a múzeum pincéjében, mely a ’Líceumi Lelécelés’ nevet kapta, több korosztály számára is izgalmas kalandokat tartogat. A maximum 15 fős nyomozós játék elsősorban az általános-és középiskolák diákjait tekinti célközönségének, azonban családok, gyülekezetek vagy akár egyéni látogatók számára is jelenthet izgalmas időtöltést, hétköznapokon és hétvégén egyaránt, előzetes bejelentkezést követően. A kiállítás tematikájához szervesen kapcsolódó, történelmet, irodalmat és matematikát ötvöző szabadulószobában a rejtvények helyes megfejtése után a látogatók együtt szökhetnek meg az ifjú Petrovics Sándorral a selmecbányai líceumból, miközben megismerhetik a híres költő diákéveit. Jelen tanulmány bemutatja, miként vált a múzeumi ismeretterjesztés egyik fontos elemévé a hat hónapon keresztül működő szabadulószoba és milyen célközönség számára jelent ideális programot. Részletezem továbbá azt is, hogy a számos eszközt, tárgyat és furfangos segédletet tartalmazó, szórakoztató és élményalapú tanulásra épülő játék hogyan válik alkalmassá egyes készségek fejlesztésére, mint a rendszerszintű gondolkodás, vagy miként fejleszti a szociális képességeket, mint az alkalmazkodást, valamint a kooperációt, és ezáltal miért válik izgalmassá főként az iskolás korosztály számára.
TÜRKİYE’DE CEMAAT- SİYASET İLİŞKİSİ: İSKENDERPAŞA CEMAATİ ÜZERİNDEN BİR ANALİZ
Authors: IŞIK Muhittin
Published: September 2023

Tarihsel süreçte sosyal alanlarda aktif olarak yer alan cemaatler, çoğu zaman siyasi alanı da dolaylı ya da doğrudan bir şekilde etkilemişlerdir. Bu çalışmada Türkiye’de cemaat-siyaset ilişkisi İskenderpaşa Cemaati özelinde ele alınmıştır. Bu doğrultuda öncelikle ana hatlarıyla Türkiye’deki cemaatlerin siyasetle ilişkisi ele alınmış, sonrasında ise kökleri çok eskilere dayanan İskenderpaşa Cemaati’nin siyasal alandaki rolü irdelenmiştir. İskenderpaşa Cemaati’nin siyaset ile ilişkisi irdelenirken 1980 öncesi ve sonrası şeklinde müstakil iki başlık açılmıştır. Bu kapsamda 1980 öncesinde Millî Görüş Hareketi’nin iki önemli siyasal partisi Millî Nizam Partisi ve Millî Selamet Partisi’ne gerek kuruluş süreçlerinde gerekse sonrasında tam destek veren İskenderpaşa Cemaati, 1990’lı yıllarda Millî Görüş’ten desteğini çekmiştir. 2000 sonrasında ise İskenderpaşa Cemaati Sağduyu Partisi’ni kurmuş olmakla beraber kimi zaman Adalet ve Kalkınma Partisi’ni kimi zaman Milliyetçi Hareket Partisi’ni desteklemiştir.
The Effects of Workload Difference Between Limbs in Plyometric and Strength Exercises in Reducing Asymmetry in Change of Direction Ability During Basketball Season
Authors: Ujaković Filip , Šarabon Nejc
Published: September 2023

Ujaković, F, and Šarabon, N. The effects of workload difference between limbs in plyometric and strength exercises in reducing asymmetry in change of direction ability during basketball season. J Strength Cond Res 37(11): 2282–2288, 2023—The topic of interlimb asymmetries has recently been extensively investigated; despite that, intervention for purpose of reducing them have been narrowly examined. The present study investigated the effects of maximal strength and plyometric resistance training program with 3:1 workload ratio (nondominant to dominant side) on change of direction deficit (CoDdef) asymmetry during the basketball season. Thirty-six highly trained male basketball players (19.3 ± 4.9 years) from different age categories (U-17, U-19, and senior) were divided into 2 groups: the control group (n = 18) and the intervention group (n = 18). The intervention group performed once-a-week training that consisted of strength (Bulgarian split squats) and jumping (single-leg countermovement jumps [SLCMJs]) part in which nondominant-to-dominant workload ratio was 3:1 during the 8-week period. Preintervention and postintervention testing included single-leg isometric squat, SLCMJ, 10-m sprint, and 505 test. Analysis of covariance results showed a statistically significant difference with large effect size (p < 0.05; η
2 = 0.26) when preintervention asymmetry was included as covariate. Post hoc analysis showed a statistically significant decrease in mean CoDdef asymmetry between preintervention (11.88%) and postintervention (4.47%) testing (p < 0.01, effect size [ES] = −1.37). Isometric squat strength increased on nondominant side in the intervention group (p < 0.05; ES = 0.77). No other performance or asymmetry variable showed significant change. In conclusion, a 3:1 workload of nonspecific movement task in favor of nondominant limb is an effective training strategy to reduce CoDdef asymmetry during basketball season.
O primeiro povoamento da costa desértica do Peru
Authors: Chauchat Claude , Pelegrin Jacques
Published: September 2023

Peru, país da América do Sul, cuja arqueologia é a mais bem conhecida. O conhecimento abrange o vasto território interiorano do país, onde todos os climas do planeta estão representados. Quanto à planície litorânea do oceano Pacífico, apesar de ter sido muito pesquisada, as origens do povoamento ainda são obscuras. Um dos motivos seria o fascínio que muitas gerações de arqueólogos, frequentemente vindos do Estados Unidos, têm pelas grandes civilizações da região. Outro motivo seria que estes mesmos pesquisadores, com raras exceções, apresentam lacunas na sua formação a respeito dos instrumentos líticos ainda nos nossos dias.
ANÁLISIS DEL HUMOR VERBAL EN VIÑETAS ARGENTINAS PARA TRABAJAR FUNCIONES DEL LENGUAJE EN TRASTORNOS DE LA COMUNICACIÓN SOCIAL (PRAGMÁTICO)
Authors: Delgrosso Adriana
Published: September 2023

El humor y el lenguaje son características netamente humanas. Tanto al sentido del humor como a la risa se les atribuyen importantes beneficios físicos, psicológicos y sociales. Las dificultades del lenguaje en su relación con sus usuarios y usuarias y las circunstancias de la comunicación se denominaron Síndrome Semántico Pragmático, Trastorno Pragmático del Lenguaje (TPL) y, actualmente, Trastorno de la Comunicación Social (Pragmático). Los recursos que se aplican en los casos clínicos son seleccionados por el terapeuta en virtud de las posibilidades que pueda brindarle en cada paciente en particular. El objetivo de este trabajo es el de indagar acerca de la selección de viñetas humorísticas para utilizarlas como recurso terapéutico en el trabajo clínico de las funciones del lenguaje en pacientes con déficits en la comunicación humana. Es un estudio cualitativo donde se analizan viñetas de los humoristas argentinos Tute y Szoka, desde la metodología de análisis del discurso. Las unidades de análisis son las interacciones dialógicas establecidas entre los personajes desde el punto de vista metalingüístico. Las categorías de análisis son las funciones del lenguaje que describió Jakobson. En todas las viñetas pudo identificarse la función lingüística en la que recaía el discurso del usuario de la lengua. Este recurso entonces resulta viable porque ofrece diálogos que permiten abordar la función donde se pone el énfasis discursivo. En el trastorno pragmático, el beneficio del trabajo clínico llevado a cabo con viñetas humorísticas radicaría tanto en que un paciente pueda identificar la función como que el acto de reconocerla le produzca un efecto gracioso.

Funciones del lenguaje - Humor – Recursos terapéuticos - Trastorno de la comunicación (pragmático)
Pandemia e transformação digital no interior de Minas Gerais
Authors: Silvestre Juliane , Freitas Vérica , Freitas de Paula Verônica
Published: September 2023

Objetivos do estudo: Este caso de ensino objetiva fomentar a análise e as discussões sobre transformação digital em empresas, especialmente diante de situações adversas extremas e inesperadas, como é o contexto pandêmico vivenciado pelo surgimento do SARS-CoV-2.
Metodologia/abordagem: Este caso tem como foco as Micro e pequenas empresas. Foram coletados dados e informações, por meio de entrevistas, de três organizações localizadas na região do Triângulo Mineiro e do Alto Paranaíba.
Principais resultados: Os resultados apontam as ações tomadas pelos gestores, notadamente as que possuem relação com alguma forma de digitalização do negócio, como a da adoção do uso de aplicativos e de redes sociais, bem como as consequências da implementação dessas ações.
Contribuições acadêmicas: Este caso pode ser aplicado a estudantes do ensino superior dos cursos vinculados à gestão organizacional, uma vez que contribui para o fortalecimento de teorias vinculadas à transformação digital e à gestão de crises em momentos adversos, como a pandemia.
Contribuições práticas: Este caso possibilita diversas formas de análise, abordagem, uso e discussão a alunos, professores, gestores e interessados no tema.
O BRASIL É OURO? INDICADORES DE DESEMPENHO NA GESTÃO DO LEGADO OLÍMPICO
Authors: Meneses Ebio , Leticia Pereira Amâncio Dayse
Published: September 2023

O caso trata da gestão do legado esportivo, mais precisamente do período pré e pós Jogos Olímpicos Rio 2016, sob a ótica de um dos indicadores de desempenho, qual seja a proporção de municípios com infraestrutura atendida pelo Ministério do Esporte. Visando uma projeção única, com novas oportunidades para o esporte no Brasil, a organização dos Jogos Rio 2016 envolveu a distribuição de recursos para vários estados do país melhorarem sua infraestrutura esportiva que deixaria um legado capaz de promover o desenvolvimento do esporte brasileiro. Discussões são possibilitadas a respeito de um dos objetivos do PPA – desenvolver ações que contribuam para a geração do legado esportivo – de forma a, partindo da visão de um dos gestores da Prefeitura Municipal do Rio de Janeiro, analisar o risco da existência de estruturas deficitárias pós Olimpíadas, bem como as possibilidades de melhor utilizá-las e geri-las, mediante o suporte de indicadores de desempenho adequados que envolvam, além dos contextos político e econômico, o âmbito social. Este caso pode ser utilizado para promover discussões e debates em disciplinas de graduação e pós-graduação relacionadas a estudos na área de administração financeira, orçamento, administração pública, gestão esportiva e principalmente avaliação de políticas públicas a partir de indicadores de desempenho como, por exemplo, os 3 E’s (Eficiência, Eficácia e Efetividade) e o Balanced Scorecard (BSC).
DESAFIOS OPERACIONAIS DE OPERADORAS DE CICLOVIAGENS: ABORDAGENS E VIVÊNCIAS
Authors: Ribeiro de Oliveira Rodrigo , Reis da Silva Natalya , Gonçalves Wellington , Jose de Souza Raul
Published: September 2023

O Brasil é referência no turismo de aventura, registrando em 2015 um crescimento anual deste setor entre 15% e 25%, o que tende a continuar em um cenário pós-pandêmico, sobretudo em função da busca por atividades ecológicas e novas experiências. Assim, as cicloviagens, que têm a bicicleta como principal meio de transporte, compõem esse cenário. A experiência oferecida aos consumidores no mercado, inclusive ao turista, é resultado de um planejamento eficiente do processo de prestação do serviço, por isso, nas últimas décadas, a logística vem ganhando espaço nas discussões dentro das empresas. Dessa forma, este trabalho teve como objetivo verificar os desafios enfrentados na oferta dos serviços turísticos de aventura de cicloviagens com suporte, sendo embasado no Sistema de Turismo (SISTUR). Como unidade de pesquisa foram  utilizados múltiplos casos em que três operadoras de turismo de São Paulo foram entrevistadas via e-mail e WhatsApp, nos meses de maio a junho de 2021. Os resultados evidenciaram as distintas naturezas que compõem os desafios enfrentados por essas operadoras, sendo a precária infraestrutura das cidades receptoras, a articulação dos elementos para a oferta das cicloviagens com suporte, o transporte da bicicleta e a ausência na flexibilidade de datas nos de serviços de hospedagem para roteiros específicos de cicloviagens. A pesquisa traz contribuições teóricas e práticas, tanto as que tangem à composição de estudos científicos voltados ao turismo quanto as que possibilitam a análise, a proposição, a aplicação e o controle de alternativas que contornem os desafios elencados.
COCRIAÇÃO DE VALOR EM PROCESSOS DE RECRUTAMENTO E SELEÇÃO
Authors: Esmerio Telma , Régio Brambilla Flávio
Published: September 2023

a) Objetivos do estudo: Este trabalho propõe uma análise sobre os impactos da cocriação de valor nos processos de recrutamento e seleção entre consultoria especializada e empresas clientes, considerando o empreendedorismo em meio ao cenário da Pandemia da Covid-19.
b) Metodologia/abordagem: Neste contexto, considera-se o modelo DART de cocriação de valor, proposto por Prahalad e Ramaswamy (2004), analisando os elementos diálogo, acesso, risco e transparência em questões pertinentes aos processos de recrutamento e seleção em duas empresas estudadas. Realizou-se pesquisa qualitativa exploratória, através do método de estudo de casos múltiplos, com aplicação de entrevistas semiestruturadas direcionadas aos profissionais das empresas Alfa e Beta, relatando os resultados de semelhanças e diferenças nas práticas cocriativas das empresas.
c) Principais resultados: O marketing digital (LinkedIn) foi analisado no intuito de identificar estratégias que possam facilitar a busca de candidatos potenciais para vagas em aberto. Também foram analisadas as sete competências comuns a todas as trajetórias de negócios e se estas podem ser desenvolvidas ou ampliadas através da cocriação de valor.
d) Contribuições acadêmicas: Como contribuições acadêmicas, este artigo faz a conexão das práticas de marketing da cocriação de valor com o contexto da gestão de recursos humanos, em específico quanto aos processos de recrutamento e seleção mediante práticas interativas.
e) Contribuições práticas: Os resultados obtidos no estudo podem ser aplicados nos processos de recrutamento e seleção, levando em consideração a abordagem do Modelo DART.
Climate and juvenile recruitment as drivers of Arctic cod (Boreogadus saida) dynamics in two Canadian Arctic seas
Authors: Herbig Jennifer , Fisher Jonathan , Bouchard Caroline , Niemi Andrea , LeBlanc Mathieu , Majewski Andrew , Gauthier Stéphane , Geoffroy Maxime
Published: September 2023

Arctic cod (Boreogadus saida) is the most abundant forage fish species in Arctic seas and plays a pivotal role in the transfer of energy between zooplankton and top predators. The dominance of Arctic cod and the Arctic’s relatively low biodiversity interact such that changing population dynamics of Arctic cod have cascading effects on whole Arctic marine ecosystems. Over the last decades, warming in the Arctic has led to a decline in Arctic cod populations in the Barents Sea, but in the Canadian Arctic these conditions have been correlated with up to a 10-fold higher biomass of age-0 Arctic cod at the end of summer. However, whether this enhanced larval survival with warmer waters endures through age-1+ populations is unknown. A better understanding of spatial variation in the response of Arctic cod populations to environmental conditions is critical to forecast future changes in Arctic ecosystems. Here, we rely on a 17-year time series of acoustic-trawl surveys (2003–2019) to test whether ice-breakup date, sea surface temperature, zooplankton density, and Arctic climate indices during early life stages affect the subsequent recruitment of age-1+ Arctic cod in the Beaufort Sea and Baffin Bay. In the Beaufort Sea, the biomass of age-1+ Arctic cod correlated with both Arctic Oscillation indices and age-0 biomass of the previous year. In Baffin Bay, the biomass of age-1+ Arctic cod correlated with previous-year North Atlantic Oscillation indices and the timing of ice breakup. This study demonstrates that climate and environmental conditions experienced during the early life stages drive the recruitment of the age-1+ Arctic cod population and helps to quantify spatial variation in the main environmental drivers.
The University: Global Institution and National Organization
Authors: Frank David John , Meyer John W.
Published: September 2023

In the following essay, we respond to the Douglass book on Neo-Nationalism and Universities (2021) and the Global Perspectives Review Symposium: Universities between Inter- and Renationalization. We see the university’s extraordinary success as a transcendent global institution fomenting tensions with specific instances of the university in national (and neo-nationalist) contexts. Attacks tend to be on organizational issues in local cases, rather than on The University as a powerful but inchoate global institution.
A tryptophan metabolite made by a gut microbiome eukaryote induces pro‐inflammatory T cells
Authors: Wojciech Lukasz , Png Chin Wen , Koh Eileen Y , Kioh Dorinda Yan Qin , Deng Lei , Wang Ziteng , Wu Liang‐zhe , Hamidinia Maryam , Tung Desmond WH , Zhang Wei , Pettersson Sven , Chan Eric Chun Yong , Zhang Yongliang , Tan Kevin SW , Gascoigne Nicholas RJ
Published: September 2023

The large intestine harbors microorganisms playing unique roles in host physiology. The beneficial or detrimental outcome of host‐microbiome coexistence depends largely on the balance between regulators and responder intestinal CD4+ T cells. We found that ulcerative colitis‐like changes in the large intestine after infection with the protist Blastocystis ST7 in a mouse model are associated with reduction of anti‐inflammatory Treg cells and simultaneous expansion of pro‐inflammatory Th17 responders. These alterations in CD4+ T cells depended on the tryptophan metabolite indole‐3‐acetaldehyde (I3AA) produced by this single‐cell eukaryote. I3AA reduced the Treg subset in vivo and iTreg development in vitro by modifying their sensing of TGFβ, concomitantly affecting recognition of self‐flora antigens by conventional CD4+ T cells. Parasite‐derived I3AA also induces over‐exuberant TCR signaling, manifested by increased CD69 expression and downregulation of co‐inhibitor PD‐1. We have thus identified a new mechanism dictating CD4+ fate decisions. The findings thus shine a new light on the ability of the protist microbiome and tryptophan metabolites, derived from them or other sources, to modulate the adaptive immune compartment, particularly in the context of gut inflammatory disorders.
Emerging principles of primary cilia dynamics in controlling tissue organization and function
Authors: Gopalakrishnan Jay , Feistel Kerstin , Friedrich Benjamin M , Grapin‐Botton Anne , Jurisch‐Yaksi Nathalie , Mass Elvira , Mick David U , Müller Roman‐Ulrich , May‐Simera Helen , Schermer Bernhard , Schmidts Miriam , Walentek Peter , Wachten Dagmar
Published: September 2023

Primary cilia project from the surface of most vertebrate cells and are key in sensing extracellular signals and locally transducing this information into a cellular response. Recent findings show that primary cilia are not merely static organelles with a distinct lipid and protein composition. Instead, the function of primary cilia relies on the dynamic composition of molecules within the cilium, the context‐dependent sensing and processing of extracellular stimuli, and cycles of assembly and disassembly in a cell‐ and tissue‐specific manner. Thereby, primary cilia dynamically integrate different cellular inputs and control cell fate and function during tissue development. Here, we review the recently emerging concept of primary cilia dynamics in tissue development, organization, remodeling, and function.
RELATIONSHIP BETWEEN MANUAL MATERIAL HANDLING AND MUSCULOSKELETAL DISORDER AMONG MECHANICS AT TYRE SERVICE CENTER
Authors: Mazlina Kamarudzaman  , Nurul Elyna Asyiqen Mohd Zaki  , Mohd Nasrull Abdol Rahman
Published: September 2023

Musculoskeletal disorders (MSDs) are major contributors to work-related disability and time lost caused by illness. As manual material handlers, mechanics are frequently exposed to the physical risk factors for MSDs. The objective of this study is to investigate the relationship between manual materials handling and snook mital table among mechanics at tyre service center.  This study was conducted in Taiping, Perak. There were 239 of mechanics from various workshops participated in these study with mainly lifting/lowering, pushing/pulling, and carrying tasks. Data were collected using a structured questionnaire and interview session which are Nordic Musculoskeletal Questionnaire (NMQ) and Snook Table. NMQ was used to evaluate the exposure of the activities and related physical risk factors that had correlated to one of the region's bodies within a 12-month period while Snook is required for evaluation of the maximum acceptable weight for lifting/lowering, pushing/pulling and carrying. In this research, most mechanics have suffered musculoskeletal symptoms in low back, shoulder, and neck pain. According to  Snook analysis, most mechanics are at a medium risk of developing musculoskeletal symptoms as a result of their lifting, lowering, and carrying activity. Several definitions of pain showed a strong correlation between Snook assessment and musculoskeletal disorders. Various possible risk factors of manual materials handling activity, notably the lifting floor to knuckle and lowering floor to knuckle, each had a significant impact on the low back while shoulder and neck showed a significant relation between with lifting above shoulder. Therefore, ergonomic awareness between mechanics should be increased in order to reduce the prevalence of musculoskeletal symptoms and control the manual materials handling activity. The study will be useful to ergonomists, researchers, consultants, workshop managers, maintenance workers and others concerned with identifying ergonomic risk factor on the workplace.
Transient response analysis of a resonant cavity enhanced light emitting diode
Authors:   Radiation Engineering Dept. National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt, Eladl Sh.M. , Nasr A. ,   Radiation Engineering Dept. National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt
Published: September 2023

This article is devoted to a theoretical evaluation of the transient behavior of a light emitting diode with a resonant cavity called the resonant cavity enhanced light emitting diode (RCELED). The used analytical model is based on applying the convolution theorem for a step input signal and the transfer function of RCELED in the presence of photon recycling. Influence of the efficiency of extraction due to photon recycling on the output optical power is analyzed. The target parameters characterizing the transient behavior are investigated. A traditional light emitting diode with no photon recycling is compared to a diode with photon recycling. The obtained results show the improvement of the output optical power and the rise time with the increase of extraction efficiency and in the presence of photon recycling in the light emitting diodes. The light emitting diode considered here reaches the highest steady state output power within 2 ns. Therefore this diode model may be used for fast speed and high optical gain applications such as in thermal imaging systems and short reach optical interconnects.
Laypeople’s (Mis)Understanding of Common Medical Acronyms
Authors: Praska Corinne , Pitt Michael B. , Marmet Jordan , Gotlieb Rachael , Charpentier Victoria , Hause Emily , Allen Katherine A. , Lunos Scott , Hendrickson Marissa A.
Published: September 2023

OBJECTIVES

Abbreviations are often used in medicine yet may be a source of confusion for patients and their families. We aimed to determine the general public’s understanding of commonly used medical acronyms.

METHODS

For this cross-sectional study, we surveyed state fair visitors regarding their understanding of 5 common medical acronyms. An electronic survey was administered to a volunteer sample of adults who spoke and read English and who had never trained to work in medicine or nursing. Free-text responses were coded as correct, partially correct, or incorrect by 2 independent researchers, adding a third researcher if consensus was not reached. Analysis methods included descriptive statistics, Fisher exact tests, and multivariable logistic regression models.

RESULTS

We recruited 204 volunteers (55% female; mean age 43 years; 67% had a bachelor’s degree or higher). ED (emergency department) was correctly defined by 32%, PCP (primary care provider/physician) by 18%, CBC (complete blood count) by 14%, and PRN (as needed) and NPO (nothing by mouth) by 13% each. Female gender was associated with higher odds of correctly understanding NPO (odds ratio, 3.11; 95% confidence interval, 1.18–8.21; P = .02); older age was associated with higher odds of understanding PRN (odds ratio, 1.03; 95% confidence interval, 1.00–1.05; P = .04). Education level was not found to correlate significantly with successful explanation of any tested acronym.

CONCLUSIONS

Medical acronyms are a predictable source of miscommunication. In this large cross-sectional study, none of the acronyms evaluated was understood correctly by more than one-third of adults. Clinicians should avoid using acronyms with patients and families to minimize confusion.
Morphological diversity of the UN Cotové papaya (Carica papaya L.) variety grown under tropical dry forest conditions
Authors: Loaiza Ruiz Ruby Alejandra , Otalvaro Gutiérrez Julián David , Cartagena Valenzuela José Régulo , Barrera Sanchez Carlos Felipe , Córdoba Gaona Oscar de Jesús
Published: September 2023

This work aimed to describe the morphological diversity of the UN Cotové papaya variety to identify outstanding plants that can be used to obtain a new local cultivar. 18 individuals were selected, and the multivariate non-hierarchical cluster technique analyzed data. A Polynomial regression model was carried out to describe growth as a function of growing degree days. The ANOVA identified significant differences between plants for most morphological variables. The Pearson correlation showed linear dependence; all the variables had a high correlation (higher than 0.82) with plant height. The Hopkins and Gap statistic determined two clusterings: Gropu "D" with higher development and group "A" with less development for all parameters. Second-order polynomial model were the best fit for the plant height, and third-order models were the best fit for the others. The non-linear functional models were not significant for the evaluated variables, presenting "Lack of Fit" values greater than 0.05. The results provided information for selecting plants with outstanding characteristics that can be used in the papaya breeding program.
Application of a spatial risk model of the crystalline spider mite (Oligonychus sp.) to avocado crop damage using remote sensing
Authors: Báñez Aldave Harry Wilson , Cuesta Herrera Ledyz , López Hernández Juan Ygnacio , Andrades Grassi Jesús Enrique , Torres Mantilla Hugo Alexander
Published: September 2023

The avocado is one of the most consumed foods in the world and it is affected by the mite Oligonychus sp., which affects the generation of chlorophyll by the plant, resulting in a decrease in productivity. Given the economic importance of the avocado, a spatial statistical methodology was used to analyze the risk of a pest in its crops. A total of 202 observations of a 1.1 ha avocado farm were used to measure the number of mites per leaf in the area of Barranca, Perú. Predictive geostatistical methods and indicators were applied. A Spherical semivariogram was adjusted to estimate a Univariate Ordinary Kriging, covariates such as vegetation indicators and geomorphometric variables were used to improve the spatial resolution of the covariates and geostatistical simulation was used and linear co-regionalization models were adjusted with which pest predictions were made with co-Kriging. Finally, the predictions were transformed into a risk model using Kriging Indicator. The results obtained show that the mite presents a stationary process in second order with spatial dependence of less than 10 m, in which univariante Ordinary Kriging was the most efficient. Despite the results, the linear co-regionalization models are consistent, but the geostatistical simulation was not enough to improve the predictions. Covariate data should be incorporated at a higher level of detail and small-scale variations should be analyzed. It is suggested to incorporate covariate data with a higher level of detail and analyze small-scale variations.
Long-Term Trends in Seasonality and Abundance of Three Key Zooplankters in the Upper San Francisco Estuary
Authors:   California State Water Resources Control Board, Bashevkin Samuel , Burdi Christina ,   California Department of Fish and Wildlife, Hartman Rosemary ,   California Department of Water Resources, Barros Arthur ,   California Department of Fish and Wildlife
Published: September 2023

Zooplankton provide critical food for threatened and endangered fish species in the San Francisco Estuary (estuary). Reduced food supply has been implicated in the Pelagic Organism Decline of the early 2000s, and further changes in zooplankton abundance, seasonality, and distribution may continue to threaten declining fishes. While we have a wealth of monitoring data, we know little about the abundance trends of many estuary zooplankton species. To fill these gaps, we reviewed past research and then examined trends in seasonality and abundance from 1972 to the present of three key but understudied zooplankton species (Bosmina longirostris, Acanthocyclops spp., and Acartiella sinensis) that play important roles in the estuary food web. We fit Bayesian generalized additive mixed models of each taxon’s relationship with salinity, seasonality, year, and geography on an integrated database of zooplankton monitoring in the upper estuary. We found marked changes in the seasonality and overall abundance of each study species. Bosmina longirostris no longer peaks in abundance in the fall months, Acanthocyclops spp. precipitously declined in all months and lost its strong relationship with salinity, and A. sinensis adult abundance has become more strongly related to salinity while juveniles have developed wider seasonal abundance peaks. Through these analyses, we have documented the relationship of each species with salinity and seasonality since the beginning of monitoring or their introduction, thus increasing our understanding of their ecology and importance in the estuary. These results can inform food-web models, be paired with fish data to model the contributions of these species toward fish abundance trends and be mirrored to elucidate other species’ trends in future studies.
An Approach to Defining a Sacramento River Fall Chinook Escapement Objective Considering Natural Production, Hatcheries, and Risk Tolerance
Authors:   National Marine Fisheries Service, NOAA, Satterthwaite William
Published: September 2023

The escapement objective used to manage fisheries on Sacramento River Fall Chinook (SRFC) was established in 1984. Despite substantial changes to the system and multiple calls to re-evaluate the objective, data and analytical limitations have slowed progress. Synthesizing the available information is further complicated by the different measurement scales employed by relevant studies. Here, I offer a modeling framework for integrating consideration of established hatchery spawning goals, natural-area production or habitat capacities measured at varying spatial scales, and policy decisions about what fraction of potential natural production is desired along with risk tolerance. The model allows evaluating how likely a potential escapement goal (measured at the currently-used scale of fall run adults returning to both hatcheries and natural areas throughout the Sacramento Basin) is to both meet hatchery goals and to produce at least a specified fraction of potential natural production. The framework also incorporates consideration of forecasting and harvest planning error into identifying a pre-season planning target and its probability of resulting in escapement at least as high as the goal. The model indicates that the low end of the current escapement goal range of 122,000-180,000 adults, if achieved, would be more likely than not to achieve hatchery goals while achieving around 50% of potential natural production. Realized escapement equal to the high end is modeled to be highly likely to achieve hatchery goals and likely to achieve around 75% of potential basin-wide natural production or around 60% of Upper Sacramento potential production. The model indicates diminishing returns from total adult SRFC escapements higher than about 300,000 adults. However, past performance of forecast and harvest planning models suggest that a preseason target higher than the ultimate escapement goal is needed to have even a 50% chance of achieving the escapement goal.
The beneficial effects of enriched diet on testicular blood flow and seminal parameters using colour and pulsed Doppler ultrasound in dogs
Authors: Abdelnaby E. A. , Abd El khalek Kh. G. , Emam I. A.
Published: September 2023

Maintenance of the reproductive fitness quality in dogs is a field of interest in animal practice. Therefore, this study was conducted for the first time to predict the response of sub-fertile dogs to vitamin and mineral supplementation by evaluating testicular haemodynamics and measuring the changes in peak systolic velocity (PSV), end-diastolic velocity (EDV), resistance index (RI), and pulsatility index (PI). Dogs were categorised into three groups (15 in each group): control, vehicle group and supplemented group. Semen evaluation, blood sampling and Doppler were performed on days (D) 0, 30, 60, and 90. In the sub-fertile dogs, semen volume increased from D0 to D90, and Doppler indices correlated negatively (P≤0.05) with testicular blood velocities, nitric oxide metabolites (NO), testosterone levels, scrotal circumference, testicular volume, and testicular coloured area. Doppler indices decreased (P≤0.05) in the hypospermic males from D0 to D90 compared to the normal values. The supplementation improved significantly blood flow by elevating the testicular colouration and decreasing both Doppler indices as the increase in testicular coloured pixels in the supplemented males may be accompanied by an increase in testicular volume, testosterone, and nitric oxide levels.
A halál időpontjának becslése légypeték vizsgálatával
Authors: Bozó Csaba
Published: September 2023

Az igazságügyi rovartan az igazságügyi orvostanhoz szorosan kapcsolódó interdiszciplináris tudományterület, amely igazságügyi eljárás keretében vizsgálja a rovarokat. Az emberöléses bűncselekmények helyszínén, ha rovartani maradványok vannak az áldozaton, nagy segítséget nyújtanak a halál körülményeinek feltárásában. A döglegyek (Diptera: Calliphora) rendszerint elsőként kolonizálják a holttestet, ezért ezek a helyszínen vagy a boncteremben a leggyakrabban észlelt állatcsoportok közé tartoznak. Az esettanulmányban bemutatom, hogy a kettős emberölés áldozatán talált, igazságügyi jelentőségű légyfaj petéinek vizsgálatával hogyan lehetett megállapítani a halál időpontját, és ennek milyen jelentősége volt a bizonyítás szempontjából. Az egyik áldozaton, a férfin talált légypetéket hagyományos fénymikroszkópos, pásztázó elektronmikroszkópos és mikro-komputertomográfiás módszerekkel vizsgáltam. Az ügyben ezekkel a technikai eszközökkel elvégzett szakértői vizsgálatoknak döntő jelentőségük volt a megjelenő rovarfaj meghatározásában és fejlődési állapotának azonosításában. A döglegyek segítségével sikerült – egyéb nyomozati adatokkal együtt – igazolni, hogy az elkövetéssel gyanúsított személy a bűncselekmény időpontjában a helyszínen tartózkodott. Orv Hetil. 2023; 164(38): 1518–1522.
Behavioral Intentions of Customers Under the Technology Acceptance Model (TAM): Example of Migros Jet Kasa
Authors: GÜMÜŞ Cemal , FINDIKLI Selda , SAYGIN Emine Pınar
Published: September 2023

This study aims to reveal the attitudes and intentions of consumers towards self check-out points in their grocery shopping. For this purpose, a questionnaire was applied to consumers who used the Migros Jet Kasa (self check-out) payment points in Migros shopping stores at least once. In this direction, the results of the survey answered by 383 people were analyzed. As a result of the study it has been observed that technology use proficiency has a positive effect on both perceived ease of use and perceived usefulness. From this point of view, it can be stated that when the ability to use technology increases, perceived ease of use and perceived usefulness will increase. New technology concern does not significantly affect perceived ease of use and perceived usefulness. On the other hand, perceived ease of use affects attitude significantly and positively. Similarly, perceived usefulness also affects attitude in a meaningful and positive way. Therefore, it can be said that when both perceived ease of use and perceived usefulness increase, the attitude will increase in a positive way. Finally, attitude significantly and positively affects behavioral intention. It can be stated that when the attitude increases positively, the behavioral intention will also increase.
Ebeveynlik Tutumuna Yeni Bir Bakış: Merhametli Ebeveynlik
Authors: NAS Eşref
Published: September 2023

Bu çalışmada ebeveynlik tutumunun yeni bir bakış açısıyla ele alınması ve merhametli ebeveynlik tutumu konusunda aileler, aile danışmanları, aile-çocuk ruh sağlığı çalışanları ve araştırmacılar açısından farkındalık oluşturulması amaçlanmıştır. Bu amaç kapsamında alanyazındaki mevcut ebeveyn tutumlarından hareketle ebeveynliğin farklı stillerinden bahsedilmiştir. Ebeveynliğin çeşitli sınıflandırmalar bağlamında incelendiği anlaşılmakla birlikte genel anlamda otoriter, izin verici, kararsız, aşırı koruyucu, ihmalkâr ve demokratik tutum olmak üzere altı ebeveynlik yaklaşımının bulunduğu ortaya konulmuştur. Ayrıca ebeveyn tutumlarıyla ilişkili olan ebeveynlik uygulamaları ele alınmıştır. Ebeveynlik uygulamaları içinde özellikle ebeveyn desteği ve ebeveyn kontrolünün önemine değinilmiştir. Ardından ebeveynlerin kendilerini geliştirebilmeleri, çocuk eğitimi ve yetiştirme açısından farkındalık kazanmaları, aile içi sorunları sağlıklı bir zeminde çözüme kavuşturmaları ve çocuklarını geleceğe hazırlamada yeni yaklaşımlar edinmeleri amacıyla birtakım eğitim ve programların hazırlanıp sunulduğu tespit edilmiştir. Bu çalışmada merhamet kavramının, bir ebeveynlik tutumu çerçevesinde işlenmesi önemli görülmüştür. Merhametli ebeveynlik tutumunun anlaşılması noktasında bilgi sunulmuştur. Bu bağlamda, merhametli ebeveynlik, bir ebeveynin olayları ve durumları çocuğun bakış açısından ele alabilmesi, çocuğa gerekli sevgi, ilgi ve şefkati sunabilmesi ve çocuğun hata, başarısızlık ve yetersizliklerine karşı duyarlılık ve anlayış gösterebilmesi şeklinde özetlenmiştir. Merhametli ebeveynlik davranışsal, duygusal ve bilişsel olmak üzere üç yönden ele alınmıştır. Merhametli bir ebeveynin, merhamet içeren hedeflere sahip olabileceği göz önünde bulundurularak merhametli hedeflerin öneminden bahsedilmiştir. Bununla birlikte merhametli ebeveynlik sürecinde ortaya çıkabilecek muhtemel engeller ele alınmıştır. Söz konusu engeller, ebeveynlerin merhamet korkusu yaşayabilmeleri ve merhamet yorgunluğunu deneyimleyebilmeleri ile açıklanmıştır. Bu engeller dikkate alınarak merhametli ebeveynlik tutumunda yer alması gerekli görülen önemli bir kavramdan, öz-merhametten bahsedilmiştir. Öz-merhametli ebeveynlerin hem kendilerine karşı hem de çocuklarına yönelik merhametli duygu, düşünce ve eylemler geliştirebilmesinin mümkün olabileceği belirtilmiştir. Böylece merhametli ebeveynlik tutumunun önemli bir parçasının, ebeveynlerin kendilerine karşı merhametli olmalarıyla açıklanabileceği anlaşılmıştır. Son olarak ebeveynlerin merhametli ebeveynlik tutumunu geliştirebilmeleri noktasında katkı sağlayabilecek potansiyel eğitimler ve programlar önerilmiştir.