bluuebunny/crossref_metadata_2025 huggingface dataset:
Increased genital mucosal cytokines in Canadian women associates with increased antigen presenting cells, inflammatory metabolites, epithelial barrier disruption and the depletion of L. crispatus
Authors: Zuend Christina Farr , Lamont Alana , Noel-Romas Laura , Knodel Samantha , Birse Kenzie , Kratzer Kateryna , McQueen Peter , Perner Michelle , Ayele Hossaena , Mutch Sarah , Berard Alicia R. , Schellenberg John J. , Senturk Faruk , McCorrister Stuart , Westmacott Garrett , Mulhall Fran , Sandberg Bonnie , Yu Adelicia , Burnett Margaret , Poliquin Vanessa , Burgener Adam D.
Published: May 2022

Background: Cervicovaginal inflammation has been linked to negative reproductive health outcomes including acquisition of HIV, other sexually transmitted infections, and cervical carcinogenesis. While changes to the vaginal microbiome have been linked to genital inflammation, the molecular relationships between the functional components of the microbiome with cervical immunology in the reproductive tract are understudied, limiting our understanding of mucosal biology that may be important for reproductive health.Results: In this study we used a multi’-omics approach to profile cervicovaginal samples collected from 43 Canadian women to characterize host, immune, functional microbiome and metabolome features of cervicovaginal inflammation. We demonstrate that inflammation is associated with lower amounts of L. crispatus and increased levels of cervical antigen presenting cells (APCs). Proteomic analysis showed an upregulation of pathways related to neutrophil degranulation, complement, and leukocyte migration, with decreased levels of cornified envelope and cell-cell adherens junctions. Functional microbiome analysis showed reductions to carbohydrate metabolism and lactic acid, with increases of xanthine and other metabolites. Bayesian network analysis linked L. crispatus with glycolytic and nucleotide metabolism, succinate and xanthine, and epithelial proteins SCEL and IVL as major molecular features associated with pro-inflammatory cytokines and increased APCs.Conclusions: This study identified key molecular and immunological relationships with cervicovaginal inflammation, including increased APCs, bacterial metabolism, and proteome alterations that underlie inflammation. As APCs are involved in HIV transmission, parturition, and cervical cancer progression, further studies are needed to explore the interactions between these cells, bacterial metabolism, mucosal immunity, and their relationship to reproductive health.
m6A RNA Methylation Regulators de fine tumor microenvironment and predict prognosis in hepatocellular carcinoma
Authors: Gu Xiangqian , Yuan Yin , Gu Chengyu , Wu Mingyu , Cai Bin
Published: May 2022

N6-methyladenosine (m6A) modification is considered to be the most significant and abundant mRNA modification and constitutes a critical mechanism of epigenetic regulation in various tumors. However, the potential influences of these m6A regulators on the tumor immune microenvironment (TIME) and immunotherapy in hepatocellular carcinoma (HCC) remain unknown. The present research aims to explore the roles of 38 m6A regulators in HCC. We investigated the different expression patterns of the m6A regulators between normal and HCC samples. Through consensus clustering of m6A regulators, three subgroups associated with patient survival and the infiltration of immune cells were recognized. Additionally, we constructed an m6A score model based on the m6A phenotype-related differentially expressed genes (DEGs) to quantify the m6A-related subtypes of individual tumors. Patients with a low m6Ascore had a better survival rate than those with a high m6Ascore, and patients with a high TMB and high m6Ascore had a worse survival rate. Moreover, patients in the high m6Ascore group had higher PD-L1 expression than the low m6Ascore group. The low m6Ascore group showed higher immune checkpoint inhibitor responses, including anti-CTLA-4 therapy, anti-PD-1, or a combination of both, than the high m6Ascore group. In conclusion, our study revealed the potential function of these mRNA modifications in TIME and identified their immunotherapeutic value.
Forward masking in a bottlenose dolphin Tursiops truncatus: Dependence on azimuthal positions of the masker and test sources
Authors: Popov Vladimir V. , Nechaev Dmitry I. , Supin Alexander Ya. , Sysueva Evgeniya V.
Published: May 2022

Forward masking was investigated by the auditory evoked potentials (AEP) method in a bottlenose dolphin Tursiops truncatus using stimulation by two successive acoustic pulses (the masker and test) projected from spatially separated sources. The positions of the two sound sources either coincided with or were symmetrical relative to the head axis at azimuths from 0 to ±90°. AEPs were recorded either from the vertex or from the lateral head surface next to the auditory meatus. In the last case, the test source was ipsilateral to the recording side, whereas the masker source was either ipsi- or contralateral. For lateral recording, AEP release from masking (recovery) was slower for the ipsi- than for the contralateral masker source position. For vertex recording, AEP recovery was equal both for the coinciding positions of the masker and test sources and for their symmetrical positions relative to the head axis. The data indicate that at higher levels of the auditory system of the dolphin, binaural convergence makes the forward masking nearly equal for ipsi- and contralateral positions of the masker and test.
Nerolidol induced apoptosis in human laryngeal cancer cells (Hep 2) through activation of ROS and mitochondrial-mediated pathway: An in vitro and in silico study
Authors: Balakrishnan Vaitheeswari , Ganapathy Sindhu , Veerasamy Vinothkumar , Duraisamy Ramachandhiran , Jawaharlal Saranya , Lakshmanan Vennila
Published: May 2022

The aim of the present study was to examine Nerolidol (NER) and cisplatin (CIS) performed against human laryngeal carcinoma (Hep 2) cells. The MTT assay was used to assess the cytotoxicity of NER and CIS on Hep 2 cells in terms of morphological alterations. We evaluated the effect of NER, CIS, and NER + CIS on cell migration, oxidative stress (ROS), mitochondrial membrane depolarization (MMP), nuclear condensation, induction of apoptosis and DNA damage in Hep 2 cells. In addition, the molecular docking study also evaluated the structural binding interaction of the NER with the P13K/Akt and PCNA protein. The results demonstrate that IC50 values of NER and CIS and combination NER + CIS have a potential cytotoxicity against Hep 2 cells. Moreover, effectively inhibit cell viability and increased ROS generation due to induction of apoptosis in Hep 2 cells. Furthermore, the NER interaction with the PI3K/Akt and PCNA protein has a higher binding score and a high binding affinity. As a result of these findings, NER may be a promising anticancer drug in oral squamous cell carcinomas (OSCCs) by inducing apoptosis in Hep 2cells.
Chromosome-scale assembly of the lablab genome - A model for inclusive orphan crop genomics
Authors: Njaci Isaac , Waweru Bernice , Kamal Nadia , Muktar Meki , Fisher David , Gundlach Heidrun , Muli Collins , Muthui Lucy , Maranga Mary , Kaimenyi Davies , Maass Brigitte , Emmrich Peter , Entfellner Jean-Baka Domelevo , Spannagl Manuel , Chapman Mark , Shorinola Oluwaseyi , Jones Chris
Published: May 2022

Orphan crops (also described as underutilised and neglected crops) hold the key to diversified and climate-resilient food systems. After decades of neglect, the genome sequencing of orphan crops is gathering pace, providing the foundations for their accelerated domestication and improvement. Recent attention has however turned to the gross under-representation of researchers in Africa in the genome sequencing efforts of their indigenous orphan crops. Here we report a radically inclusive approach to orphan crop genomics using the case of Lablab purpureus (L.) Sweet (syn. Dolichos lablab, or hyacinth bean) – a legume native to Africa and cultivated throughout the tropics for food and forage. Our Africa-led South-North plant genome collaboration produced a high-quality chromosome-scale assembly of the lablab genome – the first chromosome-scale plant genome assembly locally produced in Africa. We also re-sequenced cultivated and wild accessions of lablab from Africa confirming two domestication events and examined the genetic diversity in lablab germplasm conserved in Africa. Our approach provides a valuable resource for lablab improvement and also presents a model that could be explored by other researchers sequencing indigenous crops particularly from Low and middle income countries (LMIC).
Expression of striated muscle Z-band alternatively spliced PDZ-motif protein LIM domain-binding 3 in the nervous system
Authors: Blech-Hermoni Yotam , Subedi Kalpana , Silver Maya , Jensen Leah , Coscia Stephen , Kates Malcolm M. , Zhao Yongmei , Raley Castle , Edwards Nancy , Tran Bao , Ray-Chaudhary Abhik , Pathak Pankaj , Mankodi Ami
Published: May 2022

LIM domain-binding 3 (LDB3) is a member of the Enigma family of PDZ-LIM proteins. LDB3 has been reported as a striated muscle-specific Z-band alternatively spliced protein that plays an important role in mechanosensory actin cytoskeleton remodeling. This study shows that LDB3 is broadly expressed in the central and peripheral nervous system of human and mouse. LDB3 is predominantly expressed in the adult stages compared to early development and at a significantly higher level in the spinal cord than in the brain. As in skeletal muscle and heart, LDB3 is extensively alternatively spliced in the neurons. Three novel splice isoforms were identified suggesting splicing-dependent regulation of LDB3 expression in the nervous system. Expression of LDB3 in the motor cortex, cerebellum, spinal motor neuron, peripheral nerve, and neuromuscular junction in addition to skeletal muscle indicates important roles for this PDZ-LIM family protein in motor planning and execution. Moreover, expression in the hippocampal neurons suggests roles for LDB3 in learning and memory. LDB3 interactors filamin C and myotilin are also expressed in the spinal motor neuron, nerve, and neuromuscular junction, thereby providing the basis for neurogenic manifestations in myopathies associated with mutations in these so-called muscle proteins.
Genetic control of rhizosphere microbiome of cotton plant under field conditions
Authors: Wei Feng , Feng Zili , Yang Chuanzhen , Zhao Lihong , Zhang Yalin , Feng Hongjie , Zhu Heqin , Xu Xiangming
Published: May 2022

Background
Understanding the extent of heritability of plant-associated microbiome (phytobiome) is critical for exploitation of phytobiome in agriculture. Two crosses were made between pairs of cotton cultivars with differential resistance to the Verticillium wilt. F2 plants were grown together with the four parents to study the heritability of cotton rhizosphere microbiome. Amplicon sequencing was used to profile bacterial and fungal communities.
Results
F2 hybrid offspring of both crosses had higher alpha diversity indices as well as greater variability than the two parents. Two types of data were used generated to study the heritability of rhizosphere microbiome: principal components (PCs) and individual top microbial OTUs. For the L1×Z49 cross, the variance among the 100 progeny genotypes (VT) was significantly greater than the random variability (VE) for 12 and 34 out of top 100 fungal and bacterial PCs, respectively. For the Z2×J11 cross, the corresponding values were 10 and 20 PCs. Out of the top 100 OTUs, 29 fungal OTUs and 10 bacterial OTUs had VT that was significantly greater than VE for the L1×Z49 cross; the corresponding value for the Z2×J11 cross were 24 and one. The estimated heritability was mostly in the range of 40–60%.
Conclusions
These results suggested the existence of genetic control in terms of rhizosphere microbiome in cotton.
Audible axions with a booster: Stochastic gravitational waves from rotating ALPs
Authors: Madge Eric , Ratzinger Wolfram , Schmitt Daniel , Schwaller Pedro
Published: May 2022

Gravitational waves provide a novel way to probe axions or axion-like particles coupled to a dark photon field, even in the absence of couplings to Standard Model particles.
In the conventional misalignment mechanism, the generation of an observable stochastic gravitational wave background, however, requires large axion decay constants.
We here investigate the gravitational wave signal generated within the kinetic misalignment scenario, where the axion is assumed to have a large initial velocity.
Its kinetic energy then provides a sufficiently high energy budget to generate a detectable gravitational wave signal also at lower values of the decay constant.
We obtain an analytic estimate as well as perform numerical simulations of the corresponding gravitational wave signal, and evaluate its detectability at current and future gravitational wave observatories.
We further present the corresponding projected constraints on the parameter space of the model, along with the parameter regions in which the dark photon or axion constitute dark matter, or in which the baryon asymmetry of the Universe is generated via the axiogenesis mechanism. Finally, we compute the GW production from the fragmentation of rotating axions, which is however difficult to observe experimentally.
Fingerprints of hot-phonon physics in time-resolved correlated quantum lattice dynamics
Authors: Cappelluti Emmanuele , Novko Dino
Published: May 2022

The time dynamics of the energy flow from electronic to lattice
degrees of freedom in pump-probe setups could be strongly affected by
the presence of a hot-phonon bottleneck, which can sustain longer
coherence of the optically excited electronic states. Recently,
hot-phonon physics has been experimentally observed and theoretically
described in MgB_22,
the electron-phonon based superconductor with
T_{c}\approx 39Tc≈39
K. By employing a combined ab-initio and a semiclassical approach and by
taking MgB_22
as an example, here we propose a novel path for revealing the presence
and characterizing the properties of hot phonons through a direct
analysis of the information encoded in the lattice inter-atomic
correlations. Such method exploits the underlying symmetry of the
E_{2g}E2g
hot modes characterized by a out-of-phase in-plane motion of the two
boron atoms. Since hot phonons occur typically at high-symmetry points
of the Brillouin zone, with specific symmetries of the lattice
displacements, the present analysis is quite general and it could aid in
revealing the hot-phonon physics in other promising materials, such as
graphene, boron nitride, black phosphorus, or even underdoped
cuprates.
Ayçiçek Hasılını Farklı Oranlarda Şeker Pancarı Bitkisi ile Silolamanın Silaj Kalitesi, In-Vitro Sindirilebilirlikleri ve Enerji İçeriğine Etkisi
Authors: YILDIZ Serhat , DENİZ Suphi , ÖZKAN Fatma , ALTAÇLI Selçuk
Published: May 2022

Bu çalışma, ayçiçeği hasılı ve şeker pancarı bitkisinden kaliteli bir silaj elde etmek için, en uygun karışım oranlarının belirlenmesi amacıyla gerçekleştirilmiştir. Araştırmada hamur olum döneminde biçilen silajlık ayçiçek hasılı (tam bitki) ve şeker pancarı (yapraklar ve baş dahil tam bitki) silaj materyali olarak kullanılmıştır. Ayçiçek hasılı (A) ve şeker pancarı (ŞP) bitkileri ağırlık esasına göre %100A ve %0ŞP, %85A ve %15ŞP, %55A ve %45ŞP olacak şekilde doğranıp karıştırılarak bir litrelik cam kavanozlarda 5’er tekerrür olacak şekilde silolanmıştır. Kavanozlar 70 günlük inkubasyon süresi sonrasında analizlerin yapılması için açılmıştır. %100A ve %0ŞP, %85A ve %15ŞP, %55A ve %45ŞP gruplarında silaj kuru madde (KM, %) değerleri 24.97, 26.29 ve 28.72; silaj pH değerleri 4.39, 4.34 ve 4.41; amonyak azotu (NH3-N, mg.dl-1) değerleri 5.59, 3.65 ve 4.34; laktik asit (LA, %) değerleri 2.41, 1.91 ve 2.16; Fleig puanı nitelik değerleri iyi, pekiyi ve pekiyi; organik madde sindirilebilirliği (OMS, %) değerleri 54.60, 51.34 ve 49.42; metabolik enerji (ME, Mcal.kg-1) değerleri 1.97, 1.87 ve 1.79; net enerji laktasyon (NEL, Mcal.kg-1) değerleri ise, 1.22, 1.14 ve 1.09 olarak bulunmuştur. Çalışmada hazırlanan silajların ham besin madde kompozisyonu, fermantasyon kalite parametreleri ve in-vitro sindirilebilirlik değerleri ile enerji içerikleri dikkate alındığında, gerek saf ayçiçek hasılı, gerekse ayçiçek hasılı ve şeker pancarı karışımından, her hangi bir katkıya ihtiyaç duyulmaksızın, kaliteli silajlar elde edilebileceği; ancak %45 düzeyinde şeker pancarı bitkisi katkılı grupta OMS ve enerji içeriklerinde düşüş gözlendiği sonucuna varılmıştır.
Investigation of Structural Behavior of Piles in Liquefiable Cohesionless Soils
Authors: BAŞAR Ercan Egemen , ÇELİK Devran , UZUNDURUKAN Soner , FINDIK Münire
Published: May 2022

Piled foundation design and behaviour under static and dynamic loading (wave motion, earthquake, wind, vibration loadings of machinery) conditions are study subjects that are focus of interest recently in the geotechnical engineering applications. Liquefaction can be described as strength and stiffness loss of a loose, saturated non-cohesive soil under undrained cyclic loading as a result of increasing pore water pressures which reduce effective stress. Large deformations and lateral flow occurring in the layers of liquefied soil during earthquake could lead to strength and stiffness lose which may result with pile buckling and considerably increased earthquake damage on the superstructure. Predicting the bearing capacity and the deformation shape of the piled foundations during the earthquake is essential for the economy and the structural safety of the design. In this study model pile tests are conducted in uniform sandy soil and pile structural capacity is investigated under the effects of relative density and degree of saturation of surrounding soil, and pile embedment depth. Steel rods were used to represent the piles in the model tests. Sand soil was placed in a cylindirical tank at different thicknesses to provide for different pile embedment depths. Soils were compacted at four different compaction level to provide relative densities in the range of 45-80%. Static incremental load has been applied on the upper plate of the pile system in the tests. While the increase in the relative density affects the structural capacity of the piles positively, surrounding soil being saturated has resulted with capacity losses. Experimental results show that there is a consistency between our experimental findings and literature about deformation shape and buckling length of piles in liquified soils.
Sirtuin1-3 Deasetilazlar: Biyolojik Fonksiyonları ve Kanserde Terapötik Potansiyelleri
Authors: YILDIRIM Selma , DEMİREL Ramazan , İÇEN Meryem , ÖZDEN Özkan
Published: May 2022

Dünya üzerinde en ölümcül hastalıklar listesinde kalp-damar hastalıklarından sonra ikinci sırada yer alan kanser, genel olarak yaşla birlikte görülme sıklığı artan bir hastalık grubudur. Bununla birlikte, son yıllarda genç hastalarda da görülme sıklığının artması, araştırmacıları yeni ve alternatif tedavi arayışlarına yönlendirmektedir. Mayadaki Sir2 geninin memelilerdeki homologları olan sirtuin (SIRT) deasetilaz ailesi, tip 2 diyabet, obezite, kalp-damar hastalıkları, bazı sinir hastalıkları ve kanser gibi yaşlanmayla birlikte görülme sıklığı artan birçok hastalığın ortaya çıkmasıyla ilişkilendirilmesi, son yıllarda bu enzimlerin biyolojik rollerinin anlaşılmasına olan ilgiyi arttırmıştır. SIRT’ler DNA onarımı, apoptozis, metabolizma ve yaşlanma gibi hücresel olayların düzenlenmesindeki rolleri nedeniyle kanser tedavisinde yeni yaklaşımlar sunmaktadır. Nikotinamid adenin dinükleotide (NAD+) bağımlı Sınıf III histon deasetilazlar olarak da bilinen bu proteinlerin aktivitesini özel SIRT aktivatör ve inhibitörlerle değiştirilmesi mümkündür. Bu derlemede, SIRT proteinlerinin en çok çalışılan üç üyesi SIRT1, SIRT2 ve SIRT3’ün biyolojik rolleri, kanser ile olan ilişkileri ve SIRT’lerin aktivitelerini değiştiren yeni organik moleküllerin kanser tedavisindeki önemini araştıran güncel araştırma makaleleri derlenmiş ve Türkçe literatür eksikliğini gidermeye katkı sağlamayı amaçlanmıştır.
Üniversite Öğrencilerinin Girişimcilikle İlgili Görüşleri: Ondokuz Mayıs Üniversitesi Örneği, Samsun
Authors: AYDIN ERYILMAZ Gamze , KILIÇ Osman , SEBİK GÜNDÜZ Ceylan
Published: May 2022

Araştırmanın amacı, öğrencilerin üniversite öğrenimi sonrası kamu ve özel sektörde çalışma ya da kendi işini yapma isteğine göre girişimciliğe bakış açılarını ortaya koymaktır. Araştırma verileri, Ondokuz Mayıs Üniversitesi’nde önlisans ve lisans öğrenimi gören 266 öğrenciyle yapılan anketlerden oluşmaktadır. Araştırmada, öğrencilerin kamu ve özel sektörde çalışma ya da kendi işini yapma isteği arasındaki farklılığın belirlenmesinde ki-kare testi kullanılmıştır. Kamu sektöründe çalışmak isteyenler; iş güvencesini (%66.3), özel sektörde çalışmak isteyenler genç yaşta terfi imkânını (%35.2), girişimci olmak isteyenler ise kimseye bağımlı olmadan hayallerini gerçekleştirebilmeyi (%53.2) en önemli gerekçe olarak göstermişlerdir. Araştırma sonuçları, girişimci olma konusunda erkek öğrencilerin kız öğrencilerden daha istekli olduklarını ve baba mesleğinin öğrencinin girişimci olma isteği üzerinde etkili olduğunu göstermektedir. Girişimciliğin olumlu yönleri hakkında öğrenciler arasında öne çıkan üç önemli görüş; yaratıcılığı canlı tutması, kişisel becerilerin kullanılması ve yeniliklerin uygulanmasına imkân vermesi şeklinde belirtilmiştir. Öğrencilerin girişimcilikle ilgili olumsuz görüşleri ise; risk alma, geniş sorumluluk ve çalışanların motivasyonunu yüksek tutma gerekliliğidir. Araştırma sonuçları, öğrencilerin kişilikleriyle örtüşen işleri seçme konusunda kendi inisiyatifiyle karar verebilmelerini sağlayacak toplumsal bilinçlenmeye ihtiyaç olduğunu göstermektedir.
EFEKTIVITAS DAUN AFRIKA (Vernonia amygdalina Del) DALAM MEREDUKSI KANDUNGAN FORMALIN DAN KUALITAS FILLET IKAN NILA (Oreochromis niloticus)
Authors: Mayasari Eva , Kartini Kartini , Maherawati Maherawati , Priyono Suko
Published: May 2022

Formalin sebagai bahan pengawet pada ikan umum digunakan untuk memperpanjang masa simpan, namun penggunaan formalin berdampak buruk bagi kesehatan. Daun Afrika memiliki senyawa saponin yang mampu mereduksi kadar formalin. Penelitian ini bertujuan mengetahui efektivitas perendaman ekstrak daun Afrika (Vernonia amygdalina Del) untuk mereduksi kandungan formalin pada fillet ikan Nila (Oreochromis niloticus). Penelitian ini menggunakan Rancangan Acak Lengkap dengan satu faktor yaitu konsentrasi ekstrak daun Afrika (0%, 1%, 2%, 3%, 4%, dan 5%), dengan 3 kali ulangan. Identifikasi saponin pada ekstrak daun Afrika dianalisis secara kualitatif menggunakan metode Forth. Fillet ikan Nila direndam selam 30 menit ke dalam ekstrak daun Afrika pada masing-masing konsentrasi. Penurunan kadar residu formalin diuji secara kuantitatif menggunakan metode pereaksi Schiff. Hasil menunjukkan bahwa ekstrak daun Afrika pada konsentrasi 1%, 2%, 3%, 4%, 5% teridentifikasi senyawa saponin. Perendaman fillet ikan Nila berformalin ke dalam ekstrak daun Afrika efektif dan berpengaruh positif terhadap reduksi kadar formalin. Konsentrasi ekstrak daun Afrika 5% memiliki kadar formalin terendah sebesar 0,73 mg/Kg masih di bawah ambang batas International Program on Chemical Safety sebesar 1,5–14 mg/Kg, demikian juga kadar abu sebesar 1,04% sesuai dengan mutu ikan segar Standar Nasional Indonesia 01-2354.1-2006 yaitu kurang dari 2%. Formalin used as preservative fish is generally carried out to extend shelf life. However, the use of formalin has an adverse effect on health. Saponin compounds contained in African leaves are able to reduce formalin content. This study aims to determine the effectiveness of immersing African leaf (Vernonia amygdalina Del) extract to reduce the formalin content in tilapia (Oreochromis niloticus) fillets. The experimental design used a completely randomized design with one factor, the concentration of African leaf extract (0%, 1%, 2%, 3%, 4%, and 5%), with three-time replications. Saponin identification in African leaf extract was analyzed qualitatively using the Forth method. Tilapia fillets were immersed for 30 minutes into the African leaf extract at each concentration. The reduction in formalin content was tested quantitatively by Schiff reagent method. The results showed that the African leaf extract at a concentration of 1%, 2%, 3%, 4%, 5% identified saponin compounds. Immersion of formalin tilapia fillets into African leaf extract was effective and significantly affects reducing formalin content. The concentration of 5% African leaf extract had the lowest formalin content of 0,73 mg/Kg below the threshold of International Program on Chemical Safety 1,5-14 mg/Kg, as well as ash content of 1,04% according to the quality of fresh fish Indonesian National Standard 01-2354.1-2006 is less than 2%.
PENGARUH TRIMMING DAN PENGEMPAAN TERHADAP KUALITAS DAN DAYA SIMPAN CABAI RAWIT MERAH (Capsicum frutescens L.) DALAM BENTUK CABAI KERING DAN CABAI BUBUK
Authors: Bahar Yul Harry , Nur Ichniarsyah Annisa
Published: May 2022

Cabai merupakan komoditas utama dan salah satu fokus kegiatan pembinaan pertanian, karena sangat berpengaruh pada fluktuasi harga dan inflasi. Petani dan pelaku usaha sudah berhasil dalam teknologi produksi, akan tetapi aspek penanganan pascapanen dan pengolahan hasil masih tertinggal. Penelitian ini menjawab permasalahan tersebut dengan menggali teknologi tepat guna untuk mempercepat proses penanganan pascapanen cabai rawit merah (Capcicum frutescens L.) dengan tetap mempertahankan kualitas produk dan memperpanjang waktu penyimpanan produk. Penelitian ini secara umum dilakukan untuk meningkatkan penanganan pascapanen cabai rawit merah, dengan tujuan khusus adalah mempelajari pengaruh perlakuan trimming terhadap kualitas produk cabai kering dan cabai bubuk, mempelajari pengaruh perlakuan pengempaan terhadap kualitas produk cabai kering dan cabai bubuk, serta membandingkan keadaan dan perubahan kualitas dan daya simpan dengan adanya perlakuan trimming dan pengempaan. Penelitian dilakukan di Kampus Polbangtan Bogor, di Laboratorium Pascapanen Hasil Pertanian. Perlakuan pada penelitian yaitu proses trimming dan tanpa trimming, pengempaan dan tanpa pengempaan. Parameter yang diamati adalah kebusukan, warna, aroma, dan rasa yang dilakukan seminggu sekali selama sepuluh minggu. Pengamatan dilakukan melalui pengukuran dan uji organoleptik (scoring), pengolahan data hasil pengamatan dilakukan melalui uji-T. Hasil penelitian menunjukkan bahwa tanpa perlakuan trimming ternyata tidak berpengaruh terhadap kualitas produk cabai rawit merah kering dan bubuk, tambahan perlakuan pengempaan pada tahapan pascapanen dapat mempercepat proses pengeringan tanpa mengurangi kualitas produk, sehingga memberi keuntungan positif pada penanganan pascapanennya, dan daya simpan dan kualitas cabai rawit merah kering lebih baik dan lebih lama dari pada cabai rawit bubuk.
Conceptos básicos de trazabilidad en la producción de semillas para pequeños y medianos agricultores
Authors: Cañar Serna Dubert Yamil , Tibaduiza Castañeda Leidy Patricia , Sarmiento Moreno Luisa Fernanda , Medina Mérida Magda Jenny , López Rebolledo Leonardo Andrés , Sepúlveda Forero José Luis
Published: May 2022

Este manual reúne los conceptos esenciales para la implementación de una trazabilidad a la medida de las organizaciones de productores de material de siembra. De este modo, les permite identificar, seguir y rastrear los inventarios de producción en toda la cadena de valor con unos parámetros mínimos en la gestión de calidad. El manual está dirigido a productores, organizaciones de productores, asistentes técnicos, extensionistas agropecuarios y demás actores dedicados a la producción y acondicionamiento del material de siembra orientado tanto al autoabastecimiento como a la comercialización.
Predictors of the Acceptance of an Electronic Coach Targeting Self-management of Patients With Type 2 Diabetes: Web-Based Survey
Authors: Harakeh Zeena , Van Keulen Hilde , Hogenelst Koen , Otten Wilma , De Hoogh Iris M , Van Empelen Pepijn
Published: May 2022

Background

Type 2 diabetes (T2D) is a lifestyle-related disease whose prevalence increases with age. Diabetes self-management through mobile health (mHealth) apps enables patients with T2D to improve their health. According to the Technology Acceptance Model (TAM), technology acceptance (ie, intended use) is necessary to ensure mHealth can be implemented successfully. Therefore, the specific acceptance requirements of patients with T2D should be considered.

Objective

This cross-sectional study aims to examine the extent to which different TAM predictors are associated with the acceptance of a diabetes app including an electronic coach (eCoach; Iris app) among patients with T2D.

Methods

Using a web-based survey, data on 92 patients with T2D (mean age 62.76 years, SD 8.29 years) were collected. Acceptance of the Iris app with the TAM predictors (ie, perceived usefulness, perceived ease of use, social influence, perceived self-efficacy, perceived security, prior usage experience, perceived health, and propensity of data/information sharing) was assessed. Further, control variables (ie, gender, age, education, ethnicity, household, BMI, amount of years with diabetes, diabetes-related complaints, and medication use) were assessed.

Results

Multiple linear regression analyses showed that acceptance of the Iris app was positively associated with perceived usefulness (β=.57, P<.001), social influence (subjective norm; β=.20, P=.004), and willingness to share data (β=.25, P<.001). In addition, acceptance regarding the Iris app was higher among patients with T2D with overweight (β=.23, P=.01) or obese BMI (β=.21, P=.01). The model explained 75.8% of the variance in the acceptance of the Iris app by patients with T2D. In addition, perceived usefulness of the Iris app was positively related to perceived ease of use (β=.32, P<.001), subjective norm (β=.26, P=.004), perceived control (β=.19, P=.03), willingness to share data (β=.20, P=.01) regarding the Iris app, and perceived security regarding general use of apps/smartphone/internet (β=.15, P=.04). The model explained 58.2% of the variance in patients’ perceived usefulness about the Iris app.

Conclusions

Among patients with T2D, the belief that the use of the Iris app is helpful/beneficial, the willingness to share their Iris app data, and others’ approval of using this app can stimulate the acceptance of this app. In addition, the belief that the use of (health) apps is reliable and secure, the belief that the use of the Iris app is easy to use, a higher perceived capability and personal control with using this app, the willingness to share their Iris app data, and others’ approval of using this app can stimulate the perceived usefulness of such an app. These TAM predictors explained a high variance in acceptance and perceived usefulness of the Iris app. Implications for practice are addressed.
An economic and health outcome evaluation of telehealth in rural sepsis care: a comparative effectiveness study
Authors: Mohr Nicholas M , Schuette Allison R , Ullrich Fred , Mack Luke J , DeJong Katie , Camargo Jr Carlos A , Zachrison Kori S , Boggs Krislyn M , Skibbe Adam , Bell Amanda , Pals Mark , Shane Dan M , Carter Knute D , Merchant Kimberly AS , Ward Marcia M
Published: May 2022

Aim:
Sepsis is a top contributor to in-hospital mortality and, healthcare expenditures and telehealth have been shown to improve short-term sepsis care in rural hospitals. This study will evaluate the effect of provider-to-provider video telehealth in rural emergency departments (EDs) on healthcare costs and long-term outcomes for sepsis patients.
Materials & methods:
We will use Medicare administrative claims to compare total healthcare expenditures, mortality, length-of-stay, readmissions, and category-specific costs between telehealth-subscribing and control hospitals.
Results:
The results of this work will demonstrate the extent to which telehealth use is associated with total healthcare expenditures for sepsis care.
Conclusion:
These findings will be important to inform future policy initiatives to improve sepsis care in rural EDs.

Clinical Trial Registration:
NCT05072145
 (
ClinicalTrials.gov
)
Управление точностью металлорежущих станков. Структурно-­параметрические методы. Часть 2
Authors: Кузнецов А.П.
Published: May 2022

Обоснована классификация моделей точности металлорежущих станков на три группы, характеризующиеся количеством и видом входящих составляющих, а также достигаемым результатом. Предложена схема выбора системы снижения, коррекции, компенсации и управления точностью станка, с учетом двух классов систем управления точностью.
Cвой­ства пластика PETG после 3D-печати по технологии FFF. Часть 2
Authors: Петров П.А. , Агзамова Д.Р. , Шмакова Н.С. , Пустовалов В.А. , Сапрыкин Б.Ю. , Чмутин И.А. , Жихарева Е.Д.
Published: May 2022

Рассмотрено влияние режима 3D-печати на комплекс механических, оптических и тепловых свой­ств термопластичного прозрачного полимерного материала PETG (полиэтилентерефталат-­гликоль), обработанного по аддитивной технологии FFF (Fused Filament Fabrication). Показано наличие зависимости между коэффициентом пропускания света, толщиной образца и его ориентацией во время 3D-печати.
Ньюинжиниринг – ​путь обретения истинной силы для машиностроения России
Authors: Морозов Б.М.
Published: May 2022

Предложен пересмотр текущих технологических процессов с точки зрения наилучших доступных технологий на базе стратегии «ньюинжиниринга» путем создания цифровых двой­ников технологических процессов, формирования критериев оценки эффективности предлагаемых технологических решений и в дальнейшем формирования методики цифровой трансформации производственных компетенций всего предприятия.
“Design of Robotic Arm Controller Using Android app”
Authors: Nimje Rupali R. , Indurkar Prof. P. R. , Khatri Prof. Mrs. D. M.
Published: May 2022

Abstract: From ancient times science and technology have eased human life in all ways. So, it’s not surprising that with the advancement of human civilization human needs will be increased and technology has to be developed at the same pace. While meeting these needs and making everyday life easier, better; here comes the importance of robotic arm studies. Robot arms can be controlled by an outside user or by doing predetermined instructions. Nowadays, robot arms are broadly used in the industry and as well the medicine sector. Today, technology is developing at the same pace of rapidly increasing human needs. The work done to meet these needs makes life easier every day, and these studies are concentrated on robotic arm studies. In this project, the robotic arm can move in 4 axis directions with the help of 5 servo motors. With the help of the holder, we can hold the material and move it from one place to another. For doing this, we can connect the android application with the Arduino UNO microcontroller via the Bluetooth module. The abstract part describes why robotic arms have become so important, the introduction part describes types of it, the projected method describes the theory of the project and descriptions of components, lastly how the arm is implemented is described in experimental data and results. Keywords: Robotic arm, Bluetooth hand, wireless robot.
Detailed Energy Audit of Thermal Power Plant
Authors: Chandra Sudheer , Rizvi Tanu
Published: May 2022

Abstract: This paper presents a model based on physical and structural industrial load control. Lighting is an important service for all industries. Depending on the type of industry, industrial lighting consumes 2 to 10% of total energy. Innovation and continuous improvements in the lighting industry have opened up considerable opportunities for energy efficiency in the area. Lighting is a space that, during the design process, provides a wide range of energy efficiency by combining new & advance ener gy-saving bulbs, lamps and gears, as well as high performance techniques. It only provides an indication of some of the options a power auditor may consider when conducting an industry analysis. Energy conservation and exploration of new energy options is an acceptable solution to meet the growing demand of industry in the future. The implementation of energy research can improve equipment efficiency and thus reduce energy losses. Keywords: Energy Audit, Energy efficiency, Power, Consumption, Industry
Breast Cancer Prediction using KNN, SVM, Logistic Regression and Decision Tree
Authors: Singhal Vattsal , Chaudhary Yuvraj , Verma Sanidhya , Agarwal Umang , Sharma Mr. Paramanand
Published: May 2022

Abstract: Each year number of deaths is increasing extremely because of breast cancer. It is the most frequent type of all cancers and the major cause of death in women worldwide. Any development for prediction and diagnosis of cancer disease is capital important for a healthy life. Consequently, high accuracy in cancer prediction is important to update the treatment aspect and the survivability standard of patients. Machine learning techniques can bring a large contribute on the process of prediction and early diagnosis of breast cancer, became a research hotspot and has been proved as astrong technique. In this study, we applied five machine learning algorithms: Support Vector Machine (SVM), RandomForest, Logistic Regression, Decision tree (C4.5) and K-Nearest Neighbours (KNN) on the Breast Cancer WisconsinDiagnostic dataset, after obtaining the results, a performance evaluation and comparison is carried out between these different classifiers. The main objective of thisresearch paperisto predict and diagnosis breast cancer, using machine- learning algorithms, and find out the most effective whit respect to confusion matrix, accuracy and precision. It is observed that Support vector Machine outperformed all other classifiers and achieved the highest accuracy (97.2%). All the work is done in the Anaconda environment based on python programming language and Scikit-learn library. Keywords: Decision Tree, KNN, SVM, Malignant, Benign , Logistic Regression
Blockchain Application in the Elimination of Scholarship-based Manipulation
Authors: . Lohit , . Arka , Kaur Parminder
Published: May 2022

Abstract: Blockchain technology has many applications in terms of record-keeping, transparency, and cryptocurrency as well. Additionally, with one of its characteristics, manipulation or fraud can be eliminated. By decentralizing the data, the data becomes immutable, which means any traditional method of record-keeping that were susceptible to manipulation can be removed now. In this paper, a method to remove scholarship-based manipulation has been proposed. In many universities, there are scholarships based on the student’s family income. To support the poor and deserving in getting an education, these scholarships are a must. However, paper-based income certificates used to justify family income can be easily manipulated. Therefore, with the help of the Ethereum Smart Contract, a framework to store income certificates has been proposed. This method can be used to enter income data from the student’s family’s employer’s backend. Considering a fair and acceptable income for eligibility for the scholarship, the university can decide to go ahead with it without fearing the manipulation of income data. Keywords: Blockchain Technology, Scholarship manipulation, fraud detection, Education, Smart contract.
Question Paper Generator System
Authors: Shendure Mr. Aditya Sanjay , Khamkar Mr. Aniruddh Dagadu , Vathare Mr. Prasanna Premnath , Salavi Avadhut
Published: May 2022

Abstract: In this modern world e-book has become a basic requirement for the candidates to appear and prepare for their competitive exams within college premises. In this paper we are proposing a model system for smart question paper generation of universities. The mechanism behind this system is that many random question papers are generated along with the difficulty level of the questions in terms of percentage. After generation that particular quest ion is then mailed to the respective university. In this system administration of the database inputs set of question paper with an option of check box to tick th e correct answer. More ever weightage of the particular question in terms of marks and hours and the complexity of the question is determined. After this process whole question paper along with the weightage is stored in the database. In order to make question paper for 100 marks, admin sets all the weightage and difficulties to solve the problem. As soon as the difficulty and weightage is specified a pre doc file as per selected format will be downloaded to the admin and an electronic mail will be triggered. Range of difficulty may vary from easy, medium and hard.
Detection of Fake Currency Using KNN Algorithm
Authors: Kumar Dr. P V , Akhila V , Sushmitha B , Anusha K
Published: May 2022

Abstract: Bank currency is our country's most valuable asset, and to cause inconsistencies in money, criminals use phony notes that seem identical to the real one on the stock exchange. During demonetization time it is seen that so much fake currency is floating in the market. In general, for a human being, it is very difficult to identify forged notes from the genuine not instead of various parameters designed for identification as many features of forged notes are similar to the original one. To discriminate between fake bank currency and original note is a challenging task. So, there must be an automated system that will be available in banks or ATMs. To design such an automated system there is a need to design an efficient algorithm that can predict whether the banknote is genuine or forged bank currency as fake notes are designed with high precision. In this paper, six supervised machine learning algorithms are applied to the dataset available on the UCI machine learning repository for the detection of Bank currency authentication. To implement this we have applied Support Vector Machine, Random Forest, Logistic Regression, Naïve Bayes, Decision Tree, K- Nearest Neighbor by considering three train test ratios 80:20, 70:30, and 60:40 and measured their performance based on various quantitative analysis parameters like Precision, Accuracy, Recall, MCC, F1-Score and others. And some SML algorithms are giving 100 % accuracy for a particular train test ratio. Keywords: Support Vector Machine, Bank currency, Supervised Machine Learning
Air Pollution Detector using IOT
Authors: Mangaroliya Miteshkumar , V Haripriya
Published: May 2022

Abstract: Nowadays air pollution has turned out to be one of the significant issues because of the increment in the number of vehicles and during the time spent industrialization and urbanization. This expansion in the level of contamination brings about destructive consequences for prosperity. This Paper explains the depiction and execution of an Air Pollution detection system. The innovation grasped here is a hands-on execution of the idea of the Internet of Things. This detailed work is an exploration of the possibilities of consumption of this innovation, in this world, where natural well-being is turning into a genuine risk. The work is actualized utilizing a microcontroller board of Arduino. In this paper, make an IoT based Air Pollution Detection Monitoring System. and monitor the Air Quality using MQ2, MQ9 and Humidity & Temperature sensors. It will show the air quality in PPM (Parts Per Million) as like “Fresh Air”, “Poor Air”, “Danger Air” on LCD I can monitor it very easily.
Speech Recognition in E-Mail
Authors: H Ramya , R Saravanan.
Published: May 2022

Abstract: Speech recognition is one of the developing parts of AI and deep learning. Speech Recognition can be considered a predecessor of Voice recognition. SRE is based on speech recognition and helps send email by speaking and not by typing. Speech recognition involves PLP(Perceptual linear prediction), MFCC(Mel-frequency cepstral coefficients), and many other algorithms, which helps the software to distinguish the specific voice from the surrounding environment, make frequencies audible enough for human ears. DNN uses sound waves as data, to train the software. DNN uses Acoustic model, Pronunciation model, Language model, for speech-to-text, and text-to-speech. Keywords: Speech recognition, sound waves, audio, SMTP, e-mail server.
Las políticas culturales del Estado colombiano y la constitución de una identidad. El caso de La sombra del Caminante (2004), de Ciro Guerra
Authors: Salazar González Matías
Published: May 2022

El presente artículo tiene como objetivo comprender la incidencia de las políticas culturales llevadas adelante por el Estado colombiano en la construcción identitaria de la película La sombra del caminante (2004), de Ciro Guerra. Para ello, se revisó el trabajo institucional desde la creación del Ministerio de Cultura por Ernesto Samper, por medio de la Ley General de Cultura (1997), hasta la promulgación de la Ley de Cine (2003). Además, se caracteriza el contexto y trayectoria profesional de Ciro Guerra. Se concluye que el Estado colombiano ha buscado, mediante políticas culturales, institucionalizar un área clave para solucionar el conflicto armado. Por su parte, Guerra presenta en su película un mensaje de reconciliación con base en la verdad, la justicia y la garantía de no repetición.
Redes pasionales, redes filiatorias: El imaginario maternal en Guacho (1954), de Lucas Demare
Authors: Aimaretti María
Published: May 2022

Este artículo, que forma parte de una investigación centrada en el mapeo diacrónico de las figuraciones del universo maternal en el cine argentino, reflexiona, a propósito del filme Guacho (Lucas Demare, 1954), respecto de los modos de representación de mujeres-madre que se desvían del paradigma canónico que subordina el deseo femenino al rol reproductivo y socioafectivo de cuidado de los hijos. Desde el modelo de la historia cultural, la primera parte reconstruye, a partir de una exhaustiva labor hemerográfica, la trama material que hizo posible esta superproducción, que fue la más taquillera en 1954, tuvo exhibición internacional y migró a otros formatos mediáticos, poniéndola en correlación con su contexto sociopolítico de inscripción. Tomando herramientas críticas de los estudios de género, la segunda parte se interesa en examinar algunos de los signos que dan cuenta de aquella agencia femenino-maternal “desviada”, teniendo en consideración las estrategias narrativas y figurativas puestas en juego para su representación.
El consumo cultural en la dinámica escolar del primer año de estudios en la Universidad Veracruzana
Authors: Suárez Domínguez Jose Luis , Navarro Martínez Sergio Iván , Jiménez García Silvia
Published: May 2022

Este artículo aborda las dinámicas de consumo cultural de los estudiantes universitarios desde la relación entre la oferta y la demanda de contenido cultural, y desde la construcción de una agencia cultural de estos actores en el primer año de estudios en la Universidad Veracruzana. Mediante un estudio de caso, con una población de 436 estudiantes y el empleo de un método cuantitativo de tipo bivariado se realiza una aproximación a estos actores sociales y su modo de consumir una oferta virtual y presencial. Entre los hallazgos se encuentra un perfil de estudiantes disruptivos, quienes rompen con estructuras de consumo cultural. Se trata de un fenómeno ajeno al contexto escolar, en donde las prácticas continúan siendo tradicionales.