bluuebunny/crossref_metadata_2025 huggingface dataset:
Parishin A-loaded mesoporous silica nanoparticles modulate macrophage polarization to attenuate tendinopathy
Authors: Zhu Lisha , Wang Yu , Jin Shanshan , Niu Yuting , Yu Min , Li Zixin , Chen Liyuan , Wu Xiaolan , Ding Chengye , Wu Tianhao , Shi Xinmeng , Zhang Yixin , Luo Dan , Liu Yan
Published: March 2023

Macrophages are involved mainly in the balance between inflammation and tenogenesis during the healing process of tendinopathy. However, etiological therapeutic strategies to efficiently treat tendinopathy by modulating macrophage state are still lacking. In this study, we find that a small molecule compound Parishin-A (PA) isolated from Gastrodia elata could promote anti-inflammatory M2 macrophage polarization by inhibiting gene transcription and protein phosphorylation of signal transducers and activators of transcription 1. Local injection or sustained delivery of PA by mesoporous silica nanoparticles (MSNs) could almost recover the native tendon’s dense parallel-aligned collagen matrix in collagenase-induced tendinopathy by modulating macrophage-mediated immune microenvironment and preventing heterotopic ossification. Especially, MSNs decrease doses of PA, frequency of injection and yield preferable therapeutic effects. Mechanistically, intervention with PA could indirectly inhibit activation of mammalian target of rapamycin to repress chondrogenic and osteogenic differentiation of tendon stem/progenitor cells by influencing macrophage inflammatory cytokine secretion. Together, pharmacological intervention with a natural small-molecule compound to modulate macrophage status appears to be a promising strategy for tendinopathy treatment.
Blending controlled-release urea and urea under ridge-furrow with plastic film mulching improves yield while mitigating carbon footprint in rainfed potato
Authors: Sun Mengyuan , Ma Bin , Lu Peina , Bai Jianhui , Mi Junzhen , Liu Jinghui
Published: March 2023

Ridge-furrow with plastic film mulching and various urea types have been applied in rainfed agriculture, but their interactive effects on potato (Solanum tuberosum L.) yield and especially environments remain poorly understood. A three-year experiment was conducted to explore the responses of tuber yield, methane (CH4) and nitrous oxide (N2O) emissions, net global warming potential (NGWP), carbon footprint (CF), and net ecosystem economic budget (NEEB) of rainfed potato to two mulching practices [plastic film mulching (RM) and no plastic film mulching (NM)] and three urea types [conventional urea (U), controlled-release urea (C), and a mixture of equal amounts of conventional urea and controlled-release urea at a ratio of 1:1 (CU)] and their interactions. The results showed that RM significantly decreased cumulative N2O emissions and CH4 uptake by 4.9% and 28.4%, but significantly increased NGWP by 8.9% relative to NM. Compared with U, the C and CU produced much lower cumulative N2O emissions and NGWP and higher CH4 uptake. The interaction of mulching methods and urea type had significant influence on tuber yield and NEEB. Considering both environment and production, RMCU could not only achieve a high tuber yield and NEEB (by up to 26.5% and 42.9%, respectively), but also reduce the CF (by up to 13.7%), and therefore should be considered an effective strategy for dryland potato.
Modeling and optimization of CO2 mass transfer flux into Pz-KOH-CO2 system using RSM and ANN
Authors: Pashaei Hassan , Mashhadimoslem Hossein , Ghaemi Ahad
Published: March 2023

In this research, artificial neural networks (ANN) and response surface methodology (RSM) were applied for modeling and optimization of carbon dioxide (CO2) absorption using KOH-Pz-CO2system. In the RSM approach, the central composite design (CCD) describes the performance condition in accordance with the model using the least-squares technique. The experimental data was placed in second-order equations applying multivariate regressions and appraised applying analysis of variance (ANOVA). Thep-value for all dependent variables was obtained to be less than 0.0001, indicating that all models were significant. Furthermore, the experimental values obtained for the mass transfer flux satisfactorily matched the model values. TheR2and Adj-R2models are 0.9822 and 0.9795, respectively, which, it means that 98.22% of the variations for theNCO2is explained by the independent variables. Since the RSM does not create any details about the quality of the solution acquired, the ANN method was applied as the global substitute model in optimization problems. The ANNs are versatile utensils that can be utilized to model and anticipate different non-linear and involved processes. This article addresses the validation and improvement of an ANN model and describes the most frequently applied experimental plans, about their restrictions and generic usages. Under different process conditions, the developed ANN weight matrix could successfully forecast the behavior of the CO2absorption process. In addition, this study provides methods to specify the accuracy and importance of model fitting for both methodologies explained herein. The MSE values for the best integrated MLP and RBF models for the mass transfer flux were 0.00019 and 0.00048 in 100 epochs, respectively.
Research on schedling optimization of four-way shuttle-based storage and retrieval systems
Authors: Mao Jia , Cheng Jinyuan , Li Xiangyu , Cao Baogui
Published: March 2023

In this paper, we take the four-way shuttle system as the research object and establish the mathematical model of scheduling optimization based on the minimum time for the in/out operation optimization and path optimization scheduling problems of the four-way shuttle system. An improved genetic algorithm is used to solve the task planning, and an improved A* algorithm is used to solve the path optimization within the shelf level. The conflicts generated by the parallel operation of the four-way shuttle system are classified, and the improved A* algorithm based on the time window method is constructed for path optimization through the dynamic graph theory method to seek safe conflict-free paths. Through simulation example analysis, it is verified that the improved A* algorithm proposed in this paper has obvious optimization effect on the model of this paper.
An innovative traffic light recognition method using vehicular ad-hoc networks
Authors: Al-Ezaly Esraa , M. El-Bakry Hazem , Abo-Elfetoh Ahmed , Elhishi Sara
Published: March 2023

Car congestion is a pressing issue for everyone on the planet. Car congestion can be caused by accidents, traffic lights, rapid accelerations, deceleration, and hesitation of drivers, as well as a small low-carrying capacity road without bridges. Increasing road width and constructing roundabouts and bridges are solutions to car congestion, but the cost is significant. TLR (traffic light recognition) reduces accidents and traffic congestion caused by traffic lights (TLs). Image processing with convolutional neural network (CNN) lakes dealing with harsh weather. A semi-automatic annotation for traffic light detection employs a global navigation satellite system, raising the cost of automobiles. Data was not collected in harsh conditions, and tracking was not supported. Integrated channel feature tracking (ICFT) combines detection and tracking, but it does not support sharing information with neighbors. This study used vehicular ad-hoc networks (VANETs) for VANET traffic light recognition (VTLR). Information exchange as well as monitoring of the TL status, time remaining before a change, and recommended speeds are supported. Based on testing, it has been determined that VTLR performs better than semi-automatic annotation, image processing with CNN, and ICFT in terms of delay, success ratio, and the number of detections per second.
Feasibility of patch-type wireless 12-lead electrocardiogram in laypersons
Authors: Yoon Sunyoung , Kim Taerim , Kang Eunjin , Heo Sejin , Chang Hansol , Seo Yeoni , Cha Won Chul
Published: March 2023

Various efforts have been made to diagnose acute cardiovascular diseases (CVDs) early in patients. However, the sole option currently is symptom education. It may be possible for the patient to obtain an early 12-lead electrocardiogram (ECG) before the first medical contact (FMC), which could decrease the physical contact between patients and medical staff. Thus, we aimed to verify whether laypersons can obtain a 12-lead ECG in an off-site setting for clinical treatment and diagnosis using a patch-type wireless 12-lead ECG (PWECG). Participants who were ≥ 19 years old and under outpatient cardiology treatment were enrolled in this simulation-based one-arm interventional study. We confirmed that participants, regardless of age and education level, can use the PWECG on their own. The median age of the participants was 59 years (interquartile range [IQR] = 56–62 years), and the median duration to obtain a 12-lead ECG result was 179 s (IQR = 148–221 s). With appropriate education and guidance, it is possible for a layperson to obtain a 12-lead ECG, minimizing the contact with a healthcare provider. These results can be used subsequently for treatment.
Oxidative insertion of amines into conjugated macrocycles: transformation of antiaromatic norcorrole into aromatic azacorrole
Authors: Li Sha , Sun Yahan , Li Xiaofang , Smaga Oskar , Koniarz Sebastian , Pawlicki Miłosz , Chmielewski Piotr J.
Published: March 2023

A new group of aromatic porphyrinoids was obtained by an oxidative insertion of primary amines into the antiaromatic ring of 5,14-dimesityl-norcorrolatonickel(ii) activated by iodosobenzene.
A rapid micro chamber method to measure SVOC emission and transport model parameters
Authors: Wang Chunyi , Eichler Clara M. A. , Bi Chenyang , Delmaar Christiaan J. E. , Xu Ying , Little John C.
Published: March 2023

A rapid micro chamber method is used to measure emission model parameters of plasticizers, compared to a traditional chamber method and then applied in an exposure assessment with the DustEx webtool.
Synthesis of pyrido[1,2-a]indol-6(7H)-ones via a visible light-photocatalyzed formal (4 + 2) cycloaddition of indole-derived bromides and alkenes or alkynes
Authors: Wei Minghui , Liu Chengkou , Wang Chang-Sheng , Li Yuguang , Qiu Peng , Dong Quanxiao , Yang Zhao , Fang Zheng , Guo Kai
Published: March 2023

We successfully developed an unprecedented synthesis route to pyrido[1,2-a]indol-6(7H)-ones through a visible light-photocatalyzed formal (4 + 2) cycloaddition of indole-derived bromides and alkenes or alkynes in a microchannel reactor.
Perspective on oligomeric products from lignin depolymerization: their generation, identification, and further valorization
Authors: Han Yinglei , Simmons Blake A. , Singh Seema
Published: March 2023

A systematic summary on the current state-of-art of the formation, identification, and further valorization of oligomeric products during various lignin depolymerization processes.
A low-cost, label-free microfluidic scanning flow cytometer for high-accuracy quantification of size and refractive index of particles
Authors: Reale Riccardo , Peruzzi Giovanna , Ghoreishi Maryamsadat , Stabile Helena , Ruocco Giancarlo , Leonetti Marco
Published: March 2023

A microfluidic scanning flow cytometer, enabling measurement of angle-resolved scattered light for high performance single-cell/particle analysis.
Exploiting α-benzylated 1,4-butanesultones to expedite the discovery of small-molecule, LCST-type sulfobetaine zwitterionic materials
Authors: Chu Yen-Ho , Chen Pin-Hsuan , Huang Hsin-Heng
Published: March 2023

We report the concise synthesis and discovery of a small library of 16 small-molecule sulfobetaine zwitterionic materials that exhibit LCST phase transitions in water.
In situ formation of gold nanoparticles@supramolecular hydrogels with ultra-fast catalytic reduction of dyes and excellent anti-bacterial properties
Authors: Wang Xiao-Juan , Zhang Lang , Wei Chuan-Wan , Gao Shu-Qin , Luo Wei , Lin Ying-Wu
Published: March 2023

2-QY-Au NPs@metallohydrogel could catalyze and degrade a variety of organic dyes with an excellent catalytic activity and presented good biocompatibility and antibacterial activity.
Facile fabrication of a BiOBr–Cu2+/TiO2 suspension for efficient equipment decontamination
Authors: Zhang Jie , Tian Xuemeng , Dong Chaochao , Gao Ruixia , Hu Yuan
Published: March 2023

Utilizing BiOBr–Cu2+/TiO2 as the effective constituent of a decontamination agent for in-depth treatment and decontamination in firefighting work.
Rational design and progress of molybdenum-oxo clusters
Authors: Wang Chen , Su Tan , Zang Hong-Ying , Su Zhong-Min
Published: March 2023

This review systematically summarizes the various structures of molybdenum clusters and their potential applications in different fields, including proton conductivity, organic catalysts, photoelectric reduction of CO2, nanomedicines and others.
High-throughput surface-enhanced Raman scattering sensors for near-infrared detection of biochemical molecules
Authors: Wang Yifan , Chen Zhiming , Zeng Pan , Cao An , Zhang Tao , Li Yue
Published: March 2023

A new kind of high-throughput and highly sensitive NIR-SERS biochemical sensor is developed by combining inkjet printing technology with plasmonic Au@AuAg nanorods, which paves an effective way to achieve low-cost HNIR-SERS chips.
Plastic-derived sandwich-like porous carbon nanosheet-supported hexagonal carbon micro-flakes for K-ion storage
Authors: Kong Tianci , Qian Yong , Li Yang , Lin Ning , Qian Yitai
Published: March 2023

Novel sandwich-like porous carbon nanosheet-supported hexagonal carbon micro-flakes are fabricated via a one-step hydrothermal route with waste polyethylene plastic.
High-performing, insensitive and thermally stable energetic materials from zwitterionicgem-dinitromethyl substituted C–C bonded 1,2,4-triazole and 1,3,4-oxadiazole
Authors: Yadav Abhishek Kumar , Jujam Manojkumar , Ghule Vikas D. , Dharavath Srinivas
Published: March 2023

A series ofgem-dinitromethyl substituted zwitterionic C–C bonded azole based energetic materials (3–8) were designed, synthesized, and characterized through NMR, IR, EA, and DSC studies.
Easy and fast prediction of green solvents for small molecule donor-based organic solar cells through machine learning
Authors: Mahmood Asif , Sandali Yahya , Wang Jin-Liang
Published: March 2023

A fast machine learning based framework is introduced for the prediction of solubility parameters and selection of green solvents for small molecular donor-based organic solar cells.
Role of aluminium hydrides in localised corrosion of aluminium revealed by operando Raman spectroscopy
Authors: Mysliu Erlind , Lunder Otto , Erbe Andreas
Published: March 2023

Hydrogen evolution and aluminium hydrides were observed during filiform corrosion, indicating that hydride may be an important intermediate in aluminium corrosion.
Dual-infinite coordination polymer-engineered nanomedicines for dual-ion interference-mediated oxidative stress-dependent tumor suppression
Authors: Yao Junlie , Xing Jie , Zheng Fang , Li Zihou , Li Shunxiang , Xu Xiawei , Unay Devrim , Song Young Min , Yang Fang , Wu Aiguo
Published: March 2023

Dual-infinite coordination polymer-engineered nanomedicines Fc@Ca–TA NPs for dual-ion interference-mediated oxidative stress-dependent tumor suppression.
Facile synthesis of elemental sulfur-mediated fluorine-containing covalent triazine frameworks and their performance in lithium–sulfur batteries
Authors: Wang Shuhao , Song Yue , Wang Zhao , Xie Wei , Zhang Shuran , Yao Chan , Zhao Yanning , Xu Yanhong
Published: March 2023

The structure diagram of SFN-CTFs and the cycle diagram of SFN-CTF(1 : 2)-1 are presented.
Enhancing the activity and stability of Cu2O nanorods via coupling with a NaNbO3/SnS2 heterostructure for photoelectrochemical water-splitting
Authors: Tiwari Shalini , Yadav Priyanka , Ganguli Ashok K.
Published: March 2023

We synthesized a stable copper-based heterostructure catalyst, NaNbO3/SnS2/Cu2O for photoelectrochemical water-splitting applications with improved activity, stability, and inhibited photocorrosion in Cu2O.
Sodium hypophosphite mediated reductive amination of carbonyl compounds with N,N-dialkylformamides
Authors: Fatkulin Artemy R. , Korochantsev Vasily , Afanasyev Oleg I. , Podyacheva Evgeniya , Chusova Olga , Muratov Dmitry V. , Godovikova Maria I. , Semenov Sergei , Chusov Denis
Published: March 2023

Herein we report a transition-metal- and acid-free protocol for the reductive amination of carbonyl compounds with DMF using a substoichiometric amount of NaH2PO2·H2O. The general trends and limitations of the method were explored.
Construction of strongly-coupled CeO2/MnO2 heterogeneous catalysts for highly-efficient removal of formaldehyde
Authors: Zhang Shuaishuai , Zhang Lingling , Liu Li , Chu Xiang , Wang Xiao , Song Shuyan , Zhang Hongjie
Published: March 2023

Formaldehyde (HCHO) is highly toxic, but its low-temperature elimination is still a pressing challenge nowadays.
Parsing the basic principles to build efficient heterostructures toward electrocatalysis
Authors: Zhu Jiawei , Mu Shichun
Published: March 2023

This Chemistry Frontiers article systematically parses the inherent principles of universal component selection strategies, catalytic mechanisms, and structure–activity relationships for novel heterostructural electrocatalysts.
Site preference and defect engineering of a highly efficient blue-emitting phosphor Sr2SiO4:Ce3+/K+ toward thermally enhanced luminescence
Authors: Zhao Kai , Ma Zhihong , Yin Li , Hui Bin , Si Han , Tong Xinlin , Tang Huidong , Cao Peng , Huang Saifang
Published: March 2023

The aliovalent doping of Ce3+/K+ in α′-Sr2SiO4 leads to a thermally enhanced phosphor with bright blue emission, and electron traps modulated by defect engineering contribute to an abnormal thermal quenching phenomenon.
Investigation of structural, optical and electrical conductivity of a new organic inorganic bromide: [C12H17N2]2ZnBr4
Authors: Kammoun I. , Belhouchet M. , Ben Ahmed A. , Lhoste J. , Gargouri M.
Published: March 2023

A new organic–inorganic hybrid, namely the [C12H17N2]2ZnBr4 compound, has been synthesized and studied by single-crystal X-ray diffraction and optical and complex impedance spectroscopy.
Chaetocin disrupts the SUV39H1–HP1 interaction independent of SUV39H1 methyltransferase activity
Authors: Han Linna , Lee Jessica B. , Indermaur Elaine W. , Keung Albert J.
Published: March 2023

Chemical tools to control the activities and interactions of chromatin components have broad impact on our understanding of cellular and disease processes. It is important to accurately identify their molecular effects to inform clinical efforts and interpretations of scientific studies. Chaetocin is a widely used chemical that decreases H3K9 methylation in cells. It is frequently attributed as a specific inhibitor of the histone methyltransferase activities of SUV39H1/SU(VAR)3–9, although prior observations showed chaetocin likely inhibits methyltransferase activity through covalent mechanisms involving its epipolythiodixopiperazine disulfide ‘warhead’ functionality. The continued use of chaetocin in scientific studies may derive from the net effect of reduced H3K9 methylation, irrespective of a direct or indirect mechanism. However, there may be other molecular impacts of chaetocin on SUV39H1 besides inhibition of H3K9 methylation levels that could confound the interpretation of past and future experimental studies. Here, we test a new hypothesis that chaetocin may have an additional downstream impact aside from inhibition of methyltransferase activity. Using a combination of truncation mutants, a yeast two-hybrid system, and direct in vitro binding assays, we show that the human SUV39H1 chromodomain (CD) and HP1 chromoshadow domain (CSD) directly interact. Chaetocin inhibits this binding interaction through its disulfide functionality with some specificity by covalently binding with the CD of SUV39H1, whereas the histone H3–HP1 interaction is not inhibited. Given the key role of HP1 dimers in driving a feedback cascade to recruit SUV39H1 and to establish and stabilize constitutive heterochromatin, this additional molecular consequence of chaetocin should be broadly considered.
Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlierAtITPK4
Authors: Whitfield Hayley L. , He Sining , Gu Yinghong , Sprigg Colleen , Kuo Hui-Fen , Chiou Tzyy-Jen , Riley Andrew M. , Potter Barry V.L. , Hemmings Andrew M. , Brearley Charles A.
Published: March 2023

Myo-inositol tris/tetrakisphosphate kinases (ITPKs) catalyze diverse phosphotransfer reactions with myo-inositol phosphate and myo-inositol pyrophosphate substrates. However, the lack of structures of nucleotide-coordinated plant ITPKs thwarts a rational understanding of phosphotransfer reactions of the family. Arabidopsis possesses a family of four ITPKs of which two isoforms, ITPK1 and ITPK4, control inositol hexakisphosphate and inositol pyrophosphate levels directly or by provision of precursors. Here, we describe the specificity of Arabidopsis ITPK4 to pairs of enantiomers of diverse inositol polyphosphates and show how substrate specificity differs from Arabidopsis ITPK1. Moreover, we provide a description of the crystal structure of ATP-coordinated AtITPK4 at 2.11 Å resolution that, along with a description of the enantiospecificity of the enzyme, affords a molecular explanation for the diverse phosphotransferase activity of this enzyme. That Arabidopsis ITPK4 has a KM for ATP in the tens of micromolar range, potentially explains how, despite the large-scale abolition of InsP6, InsP7 and InsP8 synthesis in Atitpk4 mutants, Atitpk4 lacks the phosphate starvation responses of Atitpk1 mutants. We further demonstrate that Arabidopsis ITPK4 and its homologues in other plants possess an N-terminal haloacid dehalogenase-like fold not previously described. The structural and enzymological information revealed will guide elucidation of ITPK4 function in diverse physiological contexts, including InsP8-dependent aspects of plant biology.
Efficient Estimation of the Binaural Masking Level Difference Using a Technique Based on Manual Audiometry
Authors: Davidson Alyssa , Eitel Megan , Lange Rael T. , French Louis M. , Lippa Sara , Brickell Tracey A. , Brungart Douglas
Published: March 2023

Purpose:

The Masking Level Difference (MLD) has been used for decades to evaluate the binaural listening advantage. Although originally measured using Bekesy audiometry, the most common clinical use of the MLD is the CD-based Wilson 500-Hz technique with interleaved N0S0 and N0Sπ components. Here, we propose an alternative technique based on manual audiometry as a faster way of measuring the MLD. The article describes the advantages to this administration technique and evaluates if it is a viable alternative for the Wilson technique.

Method:

Data were retrospectively analyzed on 264 service members (SMs). All SMs completed both the Wilson and Manual MLDs. Descriptive and correlational statistics were applied to evaluate the comparisons between the two techniques and highlight the differences. Equivalence measures were also completed to compare the tests using a standardized cutoff score. Analyses were also made to compare both techniques to subjective and objective measures of hearing performance.

Results:

Moderate to high positive correlations were determined between Wilson and Manual measures of each threshold (N0Sπ and N0S0). Although the Manual and Wilson MLD techniques produced significantly different thresholds, simple linear transformations can be used to obtain approximately equivalent scores on the two tests, and agreement was high for using these transformed scores to identify individuals with substantial MLD deficits. Both techniques had moderate test–retest reliability. The Manual MLD and components had stronger correlations to the subjective and objective hearing measures than the Wilson.

Conclusions:

The Manual technique is a faster method for obtaining MLD scores that is just as reliable as the CD-based Wilson test. With the significant reduction in assessment time and comparable results, the Manual MLD is a viable alternative for direct use in the clinic.
Adversarial liveness detector: Leveraging adversarial perturbations in fingerprint liveness detection
Authors: Galli Antonio , Gravina Michela , Marrone Stefano , Mattiello Domenico , Sansone Carlo
Published: March 2023

The widespread use of fingerprint authentication systems (FASs) in consumer electronics opens for the development of advanced presentation attacks, that is, procedures designed to bypass a FAS using a forged fingerprint. As a consequence, FAS are often equipped with a fingerprint presentation attack detection (FPAD) module, to recognise live fingerprints from fake replicas. In this work, a novel FPAD approach based on Convolutional Neural Networks (CNNs) and on an ad hoc adversarial data augmentation strategy designed to iteratively increase the considered detector robustness is proposed. In particular, the concept of adversarial fingerprint, that is, fake fingerprints disguised by using ad hoc fingerprint adversarial perturbation algorithms was leveraged to help the detector focus only on salient portions of the fingerprints. The procedure can be adapted to different CNNs, adversarial fingerprint algorithms and fingerprint scanners, making the proposed approach versatile and easily customisable todifferent working scenarios. To test the effectiveness of the proposed approach, the authors took part in the LivDet 2021 competition, an international challenge gathering experts to compete on fingerprint liveness detection under different scanners and fake replica generation approach, achieving first place out of 23 participants in the ‘Liveness Detection in Action track’.
Cultivation of Gardenia jasminoides shoots in temporary immersion systems and optimization of the immersion periods
Authors: Krasteva Gergana
Published: March 2023

In the present study, the effect of different immersion regimes on the growth and secondary metabolites production by shoot cultures of Gardenia jasminoides Ellis, cultivated in temporary immersion systems (TIS) was investigated. The cultivation was performed for 30 days on MS medium supplemented with 4.0 mg/L BAP. The regimes of cultivation included 15 min. immersion every 4, 8 and 12 hours. The highest amount of accumulated dry biomass (ADB = 10.86 ± 0.02 g/L) was reached at 15 min. immersion at every 8 hours, whereas the lowest (ADB = 4.65 ± 0.26 g/L) was recorded when 15 min. immersion on every 4 hours was used. HPLC analyses showed that the higher polyphenol content was achieved when shoots were cultivated by using 15 min. immersion on every 12 hours. At this conditions, the shoots produced maximal amounts of chlorogenic acid (164.82±32.36ug/g DW), caffeic acid (26,90±6,80μg/g DW), rutin (891,67±122,29μg/g DW) and rosmarinic acid (559,19±19,85μg/g DW). The observed antioxidant activity (DPPH, ABTS, CUPRAC and FRAP) was following the accumulation of total phenolic. The study demonstrates that TIS are effective for cultivation of Gardenia jasminoides shoots.
Opportunities for integrated development of rural tourism enterprises, agriculture, local industry and services in rural areas in the municipality of Mineralni Bani
Authors: Lulcheva Ivanka
Published: March 2023

This article aims to study and analyze the opportunities for achieving integrated development of rural tourism enterprises, agriculture (agribusiness), industry and services in the municipality of Mineralni Bani. The guest houses and small family hotels serve products produced by their owners and other producers in the village. The system of connections and interconnections between the different types of business in Mineralni Bani municipality built not without the assistance of the municipal leadership, helps to achieve a higher degree of completion of the agricultural and animal products produced in the region (they have a higher added value). This strengthens the demand for these products and increases the tourist flow to the tourist sites in the municipality. In this way, in the municipality of Mineralni Bani, the integration between rural tourism enterprises, individual producers of agricultural products and small processing enterprises gives a strong impetus to the development of the rural area. The strengthening of this integration will lead to results that confirm the positive role and contribution of rural tourism to the stabilization of the economy of the Municipality of Mineralni Bani. In the current research carried out in the period (2014-2019), we used a methodological approach, which is implemented through specific methods: the survey and interview method, the method of comparison, synthesis and analysis, etc.
The Use of Incremental, Decremental or a Random Order of Loads does
not Affect Peak velocity Values during Bench Press Throw Load-velocity
Relationships
Authors: Sabido Rafael , Asencio Pablo , Garcia-Valverde Adrian , Garcia-Aguilar Fernando , Moreno-Lila Rodrigo , Davó Jose Luis Hernández
Published: March 2023

The aim of this study was to assess the influence of the load order used
(i. e. incremental, decremental or random loads order) during the bench
press throw load-velocity profile on peak velocity achieved against four
different loads (20–40–60–80% of one repetition
maximum [1RM]). Both intraclass correlation coefficient (ICC) and coefficient of
variation (CV) were calculated to assess the reliability of the measures. A
repeated measures ANOVA was used to assess differences between protocols. A
linear regression analysis was performed to assess the load-velocity
relationships among the different protocols. Peak velocity showed good to high
ICC values independently of the load used (ICC=0.83–0.92). CV
scores showed good reliability (ranging between 2.2 and 6.2%). No
significant differences in peak velocity attained at each load were found
between the three testing protocols (p>0.05). In addition, peak
velocity at each load was very large to almost perfect, correlated between
protocols (r=0.790–0.920). The linear regression model
showed a significant relationship between testing protocols
(p<0.001; R2=0.94). In conclusion, due to some
ICC scores below 0.9 and R2 below 0.95, the indistinct use of
different load-order protocols to assess load-velocity relationships in the
bench press throw exercise is not recommended.
Outcomes of Surgery for Benign Tumours in The Upper
Extremity
Authors: Zyluk Andrzej , Owczarska Ada
Published: March 2023

Benign tumours of the upper extremity are common in hand surgeons’
practice. The most commonly diagnosed are giant-cell tumours of the tendon
sheath and lipomas.

The objective of this study was an investigation into the distribution of
tumours in the upper limb, their symptomatology and outcomes of surgery,
particularly regarding the rate of recurrence.

Material and Methods A total of 346 patients, 234 women (68%) and
112 men (32%), who had undergone surgery for tumours located in the
upper extremity which were not ganglion cysts were enrolled into the study. The
follow-up assessment was performed at a mean of 21 months (range 12–36)
post-operatively.

Results The most common tumour in this study was giant cell tumour of the
tendon sheath − 96 cases (27.7%), followed by lipoma −
44 cases (12.7%). Most lesions − 231 (67%) were
localized in the digits. A total of 79 (23%) recurrences were noted, the
most common after surgery for rheumatoid nodules - 43.3% and the
giant-cell tumours of the tendon sheath − 31.3%. The independent
factors increasing risk of recurrence following the tumour’s resection
were: histological type of the lesion - the giant-cell tumour of the tendon
sheath (p=0.0086) and the rheumatoid nodule (p=0.0027), as well
as a combination of incomplete (non-radical) and not “en block”
resection of tumours. A brief review of the literature referring to the
presented material is offered.
Synthesis of Cyclopropylamines through an Electro-Induced Hofmann Rearrangement
Authors: Charette André B. , Poisson Thomas , Jubault Philippe , Cantin Thomas
Published: March 2023

A practical access to cyclopropylamines from the corresponding amides is disclosed, according to an electro-induced Hofmann rearrangement. In an undivided cell under galvanostatic conditions, a panel of cyclopropyl amides was readily converted into the corresponding amines (17 examples, 23% to 94% yield). This reaction allowed an easy access to the versatile cyclopropylamines and is complementary to the existing methods.
Preparation and Use of (γ,γ-Dioxyallyl)boronates
Authors: Hirano Koji , Nishino Soshi , Nishii Yuji
Published: March 2023

A copper-catalyzed stereoselective 1,4-acylboration of α,β-unsaturated esters with B2pin2 and pivalic anhydride has been developed to afford the corresponding (E)-allylboronates with two distinct oxygenated functionalities at the γ positions, which are difficult to prepare by other means. The chemoselective post functionalizations of Bpin and pivalate moieties in the product are also demonstrated.
[1,3]-Dioxolo[4,5-f]benzodioxole (DBD) Fluorescent Dyes; Synthesis, Properties, and Applications
Authors: Wessig Pablo , Lehmann Max
Published: March 2023

In this review we give an overview of the syntheses and photophysical properties of the new class of fluorescent dyes based on a [1,3]-dioxolo[4,5-f]benzodioxole core and their derivatives. Starting from commercially available reactants (e.g., sesamol, 1,2,4,5-tetrachlorobenzene) the core units can be prepared in a simple manner. Then, the benzene core can be derivatized via lithiation and their photophysical properties can be adjusted as desired. The obtained fluorophores have an absorption range of 403–520 nm and an emission range of 495–665 nm. This class of fluorescent dyes is also characterized by a long fluorescence lifetime, a high stability towards photobleaching, large Stokes shifts, and small size. Thus, the DBD dyes are optimally suited for optical sensing.

1 Introduction

2 Synthesis

3 Properties

4 Applications
General theory of the higher-order linear quaternion q-difference equations through the quaternion determinant algorithm and the characteristic polynomial
Authors: Chen Desu , Wang Chao , Li Zhien
Published: March 2023

The general theory of quaternion q-difference equations is completely different from traditional q-difference equations in the complex space for the special algebraic structure of the quaternion space, such as the non-commutativity of multiplication among elements. In this paper, some properties of basic quaternion q-discrete functions, such as the quaternion q-exponential function, are obtained. The existence, uniqueness, and extension theorems of the solution for higher-order linear quaternion q-difference equations (QQDCEs) are established through constructing quaternion q-stepwise approximation sequences, and the equivalent variable transform between higher-order linear QQDCEs and quaternion linear q-difference equations is given. Moreover, some basic results, such as the Wronskian formula, Liouville formula, and general solution structure theorems of higher-order linear QQDCEs with constant and variable coefficients, are established by applying the quaternion characteristic polynomial and the quaternion determinant algorithm. In addition, some particular and general solution formulas of non-homogeneous QQDCEs are obtained under the non-commutative condition of quaternion elements. Finally, several examples are provided to illustrate the feasibility of our obtained results.
A Chebyshev–Tau spectral method for coupled modes of underwater sound propagation in range-dependent ocean environments
Authors: Tu Houwang , Wang Yongxian , Yang Chunmei , Liu Wei , Wang Xiaodong
Published: March 2023

A coupled-mode model is a classic approach for solving range-dependent sound propagations and is often used to provide benchmark solutions in comparison with other numerical models because of its high accuracy. Existing coupled-mode programs have disadvantages such as high computational cost, weak adaptability to complex ocean environments, and numerical instability. In this paper, a new algorithm that uses an improved range normalization of a “stair-step” and global matrix approach to address range dependence in ocean environments is designed. This algorithm uses the Chebyshev–Tau spectral method to solve the eigenpairs in the range-independent segments. The Chebyshev–Tau spectral method can converge rapidly, and the rate of convergence depends on the smoothness of the sound speed and density profiles. The main steps of the algorithm are parallelized, so parallel computing technologies are also applied for further acceleration. Based on this algorithm, an efficient program is implemented, and numerical simulations verify that this algorithm is reliable, accurate, and capable. Compared with the existing coupled-mode programs, the newly developed program is more stable and efficient with comparable accuracy and can simulate waveguides in more complex and realistic ocean environments.
Scaled opposite-spin atomic-orbital based algebraic diagrammatic construction scheme for the polarization propagator with asymptotic linear-scaling effort: Theory and implementation
Authors: Ambroise M. A. , Sacchetta F. , Graf D. , Ochsenfeld C. , Dreuw A.
Published: March 2023

A novel local approach for the quantum-chemical computation of excited states is presented, where the concept of the atomic-orbital formulation of the second-order Møller–Plesset energy expression is extended to the second-order algebraic diagrammatic construction scheme by virtue of the Laplace transform. The scaled opposite-spin second-order algebraic diagrammatic construction method with Cholesky decomposed densities and density-fitting, or CDD-DF-SOS-ADC(2) for short, exploits the sparsity of the two-electron repulsion integrals, the atomic ground-state density matrix, and the atomic transition density matrix to drastically reduce the computational effort. By using a local density-fitting approximation, it is shown that asymptotically linear scaling can be achieved for linear carboxylic acids. For electron-dense systems, sub-cubic scaling can be achieved if the excitation is local, and hence the transition density is sparse. Furthermore, the memory footprint and accuracy of the CDD-DF-SOS-ADC(2) method are explored in detail.
Tunable resonance Raman scattering of quantum dots in a nonlinear excitation regime
Authors: Zhang Butian , Wang Kexin , Song Xinxin , Zhang Youwei , Chen Xue-Wen , Wang Shun
Published: March 2023

Controllable tuning of electron–phonon coupling strength and excited state dynamics is important for the understanding of resonance Raman scattering in low-dimensional semiconductors. Here, we report a significant and reversible field-induced modulation in absolute resonance Raman intensity of quantum dots using ionic liquid gating. Meanwhile, a potential-dependent nonlinear relationship is present between Raman intensity and excitation power density. By exploring the parameter space within a time domain model, we find that the Raman intensity variation is mainly determined by the homogeneous linewidth. We further propose that the Fermi level positions and exciton species play key roles in the excited state decay rates.
Is the impact sensitivity of RDX polymorph dependent?
Authors: Christopher Imogen L. , Pulham Colin R. , Michalchuk Adam A. L. , Morrison Carole A.
Published: March 2023

Impact-sensitivity predictions based on the vibrational up-pumping model show a strong polymorph dependency for RDX and highlight that one of the high-pressure forms, which forms during shock-wave experiments, is appreciably more susceptible to mechanical initiation. The origin of the predicted impact sensitivity variation can be attributed to vibrational mode hardening by pressure and to differences in the molecular conformation of RDX in the four polymorphs studied. These polymorphs present different distributions of molecular vibrations within their respective up-pumping windows, which leads to their varying ability to up-pump and trap the vibrational energy that arises from mechanical insult.
Corrigendum to: Building health workforce capacity in Northern Australia
Authors: Johnston Michael , Smith-Vaughan Heidi , Bowman-Derrick Sophie , Hopkins Jayde , McCrory Kelly , Collins Raelene , Marsh Robyn , Griffiths Kalinda , Mayo Mark
Published: March 2023

The Menzies Ramaciotti Regional and Remote Health Sciences Training Centre (Menzies-Ramaciotti Centre) is located within the Menzies School of Health Research (Menzies) in Darwin, Northern Territory (NT). The Menzies-Ramaciotti Centre is contributing to the development of a local health workforce in the NT, including a strong biomedical workforce. The Centre facilitates health workforce career progression for regional and remote youth, with a focus on career development for Aboriginal and Torres Strait Islander (First Nations) youth. The Centre works in collaboration with a range of industry and education partners, who also have strong workforce development goals and a commitment to serving a vital community need to build pathways into work and study with First Nations peoples. Part of the Centre’s focus entails delivery of high-quality training in biomedical sciences, including theoretical and practical skill development in microbiology, laboratory techniques, immunology, public health, data science, allied health, and health research. The Centre uses a non-linear, strengths-based approach to training with a multiplicity of entry and exit points including high school work experience placements, traineeships, vocational placements, as well as undergraduate and postgraduate placements.
Light-dependent signal transduction in the marine diatom
Phaeodactylum tricornutum
Authors: Agarwal Ananya , Levitan Orly , Cruz de Carvalho Helena , Falkowski Paul G.
Published: March 2023

Unlike most higher plants, unicellular algae can acclimate to changes in irradiance on time scales of hours to a few days. The process involves an enigmatic signaling pathway originating in the plastid that leads to coordinated changes in plastid and nuclear gene expression. To deepen our understanding of this process, we conducted functional studies to examine how the model diatom,
Phaeodactylum tricornutum,
acclimates to low light and sought to identify the molecules responsible for the phenomenon. We show that two transformants with altered expression of two putative signal transduction molecules, a light-specific soluble kinase and a plastid transmembrane protein, that appears to be regulated by a long noncoding natural antisense transcript, arising from the opposite strand, are physiologically incapable of photoacclimation. Based on these results, we propose a working model of the retrograde feedback in the signaling and regulation of photoacclimation in a marine diatom.
A pan-sarbecovirus vaccine based on RBD of SARS-CoV-2 original strain elicits potent neutralizing antibodies against XBB in non-human primates
Authors: Liu Zezhong , Zhou Jie , Wang Xinling , Xu Wei , Teng Zheng , Chen Hongyou , Chen Min , Zhang Guangxu , Wang Yuanzhou , Huang Jinghe , Wang Qian , Jiang Shibo , Lu Lu
Published: March 2023

The recently emerged Omicron subvariants XBB and BQ.1.1 have presented striking immune evasion against most monoclonal neutralizing antibodies and convalescent plasma. Therefore, it is essential to develop broad-spectrum COVID-19 vaccines to combat current and future emerging variants. Here, we found that the human IgG Fc-conjugated RBD of the original SARS-CoV-2 strain (WA1) plus a novel STING agonist-based adjuvant CF501 (CF501/RBD-Fc) could induce highly potent and durable broad-neutralizing antibody (bnAb) responses against Omicron subvariants, including BQ.1.1 and XBB in rhesus macaques with NT50s ranging from 2,118 to 61,742 after three doses. A decline of 0.9- to 4.7-fold was observed in the neutralization activity of sera in the CF501/RBD-Fc group against BA.2.2, BA.2.9, BA.5, BA.2.75, and BF.7 relative to D614G after three doses, while a significant decline of NT50 against BQ.1.1 (26.9-fold) and XBB (22.5-fold) relative to D614G. However, the bnAbs were still effective in neutralizing BQ.1.1 and XBB infection. These results suggest that the conservative but nondominant epitopes in RBD could be stimulated by CF501 to generate bnAbs, providing a proof-of-concept for using “nonchangeable against changeables” strategy to develop pan-sarbecovirus vaccines against sarbecoviruses, including SARS-CoV-2 and its variants.
Persistent room-temperature valley polarization in graphite-filtered WS2 monolayer
Authors: Demeridou Ioanna , Mavrotsoupakis Emmanouil G , Mouchliadis Leonidas , Savvidis Pavlos G , Stratakis Emmanuel , Kioseoglou George
Published: March 2023

Transition metal dichalcogenide (TMD) monolayers (1L) in the 2H-phase are two-dimensional semiconductors with two valleys in their band structure that can be selectively populated using circularly polarized light. The choice of the substrate for monolayer TMDs is an essential factor for the optoelectronic properties and for achieving a high degree of valley polarization at room temperature (RT). In this work, we investigate the RT valley polarization of monolayer WS2 on different substrates. A degree of polarization of photoluminescence (PL) in excess of 27% is found from neutral excitons in 1L-WS2 on graphite at RT, under resonant excitation. Using chemical doping through photochlorination we modulate the polarization of the neutral exciton emission from 27% to 38% for 1L-WS2/graphite. We show that the valley polarization strongly depends on the interplay between doping and the choice of the supporting layer of TMDs. Time-resolved PL measurements, corroborated by a rate equation model accounting for the bright exciton population in the presence of a dark exciton reservoir support our findings. These results suggest a pathway towards engineering valley polarization and exciton lifetimes in TMDs, by controlling the carrier density and/or the dielectric environment at ambient conditions.
Sustainability assessment of virtual water flows through cereal and milled grain trade among US counties
Authors: Rathore Lokendra S , Aziz Danyal , Demeke Betelhem W , Mekonnen Mesfin M
Published: March 2023

Transference of the embedded water, so-called virtual water, in the trade of crops among regions within a country is often neglected, leading to no information about the impacts on the water resources of exporting regions, especially if those regions are water-stressed or, worse, water-scarce. Virtual water trade, if not considered through the lens of sustainability, could lead to adverse effects on the water resources of an exporting region. Previous related studies have quantified virtual water trade among the states in the United States providing valuable insights; however, information for specific crop trade among counties, its water footprint (WF) at the county scale, the resultant virtual water flow among counties, and the sustainability assessment of those virtual water flows are lacking. In this study, we calculate the green and blue WF of cereal and milled grain products at the county level and then, using trade data, calculate the virtual water flows among the counties. Then, we assess the sustainability of the import by introducing unsustainable import fraction (UIF), which is the ratio of virtual water imported from water-scarce counties to that of total virtual water imported in the form of cereal and milled grains. Finally, we quantify the change in UIF from the 2007–2017 period. A few of the significant insights discovered through this analysis include: (i) most of the cereal and milled grains trade is occurring among neighboring counties; ii) one-third of US counties import 75% or more virtual water from water scarce regions; (iii) in 2017, Texas and Missouri were the largest importer and exporter, respectively; and (iv) the number of counties importing cereals and milled grains from water-scarce counties increased from 2007 to 2017. Recommendations on alleviating the negative effects of the unsustainable import of cereal and milled grain are provided toward the end of the discussion.