bluuebunny/crossref_metadata_2025 huggingface dataset:
Inhibition of Colon Cancer Xenograft Growth by Celecoxib Analog OSU-03013 Through Wnt/β-Catenin Pathway Modulation
Authors: Yang ChunYong , Zhou ZhiQiang , Tian JiaXin , Jin RuoTian , Li ZhanYong
Published: September 2024

OSU-03013 is a Celecoxib analog that dose not inhibit COX-2 expression. OSU-03013 effectively mimics the anti-tumor effects of Celecoxib, however, its exact mechanism in colon cancer (CC) is unknown. SW480 cells were injected subcutaneously into the axilla of nude mice until the volume of the transplanted tumor reached 80 mm3. SW480 cells were inoculated into the tail vein of nude mice to establish a liver metastasis model of CC. OSU-03013 was administered by gavage. The pathology of the tumor tissues was assessed using HE staining and cell apoptosis was measured using TUNEL staining. EMT markers in the tumors were determined using Western Blot, and IL-1β and TNF-α were determined using ELISA. VEGF-A and VEGFR-2 in tumor tissues were measured to assess angiogenesis using immunofluorescence. HE staining was conducted to detect the effect of OSU-03013 on liver metastasis. Western Blot assay was performed to determine the expression of Wnt2, β-catenin and GSK-3β. OSU-03013 reduced inflammatory cell infiltration and inhibited IL-1β and TNF-α production by modulating the Wnt/β-catenin pathway. OSU-03013 induced apoptosis of cancer cells in tumor tissues and possessed anti-angiogenic activity. OSU-03013 treatment reduced the number and size of metastatic nodules of cancer cells in liver tissues. OSU-03013 may inhibit tumor growth and angiogenesis through the Wnt3a/β-catenin pathway in CC nude mice.
Biological Activity, Cytotoxicity, and Phytochemical Content of Leaf Extracts of Matoa (Pometia pinnata) and Pulasan (Nephelium ramboutan-ake) From the Sapindaceae Family
Authors: Chua Vivian , Chong Li Jing , Tan Yan , Teng Xin Ying , Ng Pui Ee , Mohamed Fatnmath Eman , Koh Cai Ping , Sit Nam Weng
Published: September 2024

This study sought to assess the leaf extracts of matoa (Pometia pinnata) and pulasan (Nephelium ramboutan-ake) for antimicrobial, antifungal, antioxidant, and cytotoxic activities, besides phytochemical content. Four extracts (hexane, ethyl acetate, ethanol, and water) were obtained from each plant via sequential extraction. The antimicrobial activities were evaluated using colorimetric broth microdilution methods. The antioxidant activities were studied using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferric-reducing antioxidant power (FRAP) assays. The cytotoxicity was examined using mouse fibroblasts NIH/3T3 while the phytochemical content was detected using various chemical tests. Among the extracts, only the water extract of matoa and ethyl acetate extract of pulasan exerted bactericidal effects on Bacillus cereus (minimum bactericidal concentration (MBC): 0.63 mg/mL) and Staphylococcus aureus (MBC: 1.25 mg/mL), respectively. In contrast, all extracts, except hexane extract, of both plants exhibited fungicidal effects with minimum fungicidal concentrations of 0.31-1.25 mg/mL. All extracts of matoa leaves displayed higher DPPH radical scavenging activity and FRAP than the extracts of pulasan leaves. Notably, the water extract of matoa showed the lowest half-maximal inhibitory concentration (IC50) value of 9.88 ± 1.70 µg/mL and the highest FRAP value of 6.11 ± 0.51 mmol Fe2+ equivalent/g extract (n=3). These antioxidant activities were significantly correlated (p<0.01) with the amounts of phenolic compounds in the extracts. All extracts of both plants, except water extracts, showed significant toxicities (p<0.05) towards NIH/3T3 cells. Alkaloids, terpenoids, saponins, and glycosides were detected in the leaves of both plants. The matoa and pulasan leaves contained bioactive compounds with antibacterial, antifungal, and antioxidant activities.
Comment to: “Topology of molecular deformations induces triphasic catch bonding in selectin–ligand bonds”
Authors: Quapp Wolfgang , Maria Bofill Josep
Published: September 2024

We contradict diverse mathematical claims of a paper by Casey O. Barkan and Robijn F. Bruinsma in PNAS 2024, 121, No. 6, e2315866121, former BioRxiv preprint from Sept.12,2023. It deals with the physical mechanisms of protein-ligand catch bonding for the family of selectin proteins. Selectins exhibit slip, catch–slip, and slip–catch–slip bonding.
Vietnam’s Law on Enterprises – practice and problems raised in the process of international integration
Authors:   Ho Chi Minh City University of Technology, VNU-HCM, Vietnam, Le Tho Mong
Published: September 2024

International integration has been a major trend of the modern world. In Vietnam, the integration process is taking place strongly under the influence of many factors, of which the market economy and the rapid development of science and technology are the leading driving forces. Deep integration has led to Vietnam having to make many commitments within international economic cooperation frameworks, which has a profound impact on many areas of social life, especially the legal system. Accordingly, law on enterprises with its contributions to creating a favorable and equitable business environment, promoting the establishment, development, and business expansion of enterprises, has also undergone certain changes. The State focuses on continuously amending and supplementing the law on enterprises to suit the development of the market economy, reducing costs and time for businesses in compliance to improve business quality, and contributing to Vietnam's international integration process. In this article, the author evaluates the positive impacts of the Law on Enterprises 2020 and proposes some solutions to overcome the limitations in the provisions of the law on enterprises when applied in practice to meet the country's increasingly deep international integration requirements.
Developing the liberal education orientation in universities in Vietnam is associated with the process of international integration
Authors:   Ho Chi Minh City Open University, Vietnam, Ho Anh Ngoc , Nguyen Chau Giang ,   Ho Chi Minh City Open University, Vietnam, Tran My Duy ,   Ho Chi Minh City Open University, Vietnam
Published: September 2024

The “liberal education” orientation appeared early, and has been discussed extensively in various educational forums, as well as has been implementing in different forms at universities worldwide. The liberal education emphasizes the development of human intellect through the study of humanities, social sciences, and natural sciences. In the context of increasing international integration, the liberal education orientation is considered necessary to develop high-quality human resources. In Vietnam, the higher education system has undergone significant transformations and has become a crucial factor in the process of international integration. Vietnamese universities have the opportunity to develop the liberal education orientation due to the advantages brought about by international integration. However, it must be acknowledged that the implementation of this orientation is still not widespread and effective. The article proposes several solutions to develop the liberal education model more effectively in Vietnamese universities, including raising awareness, investing resources, strengthening international cooperation in education and research.
Promoting the role of Ho Chi Minh Communist Youth Union grassroots organizations in developing Party members of the Communist Party of Vietnam in non-state enterprises in Ho Chi Minh City - some experienced lessons
Authors:   Ho Chi Minh University of Technology, VNUHCM, Vietnam, Phan Anh Duy
Published: September 2024

Currently, the sector of non-state enterprises (SOEs) has grown strongly and played an important role in the Ho Chi Minh City's socio-economic development. Accordingly, the development of the Communist Party organizations in SOEs is an urgent task, which receives special attention from the Ho Chi Minh City Party Committee. With the participation of the whole political system, this work has achieved many important results. Ho Chi Minh City is a typical locality with many good and creative ways suitable to practical conditions to help businesses realize the role of the Party, and especially, maximize the role of Ho Chi Minh Communist Youth Union (HCYU) grassroots organizations. Recognising its honour and responsibility in building the Party and the political system of the country, the HCYU always performs the function of “the Party’s trusted successor”. This article focuses on clarifying the practice of promoting the role of HCYU grassroots organizations in developing Party members in non-state enterprises in Ho Chi Minh City, thereby drawing some lessons from experience for building the Party today.
Core success factors in attracting the foreign direct investment: a case study in some provinces of Vietnam in the context of international economic integration
Authors:   University of Finance – Marketing, HCMC, Vietnam, Le Thanh Quoc , Ho Anh Ngoc ,   Ho Chi Minh City Open University, Vietnam, Nguyen Hieu Trung ,   Ho Chi Minh city University of Technology, VNUHCM, Vietnam
Published: September 2024

The FDI is of great importance to developing countries like Vietnam. Foreign investment attraction helps bring a large amount of capital, technology, equipment, experts, and new management methods into Vietnam. The FDI helps increase employment, GDP, as well as local and national budget revenue. As a result, Vietnam in general and some provinces in particualar have financial resources to invest in other areas where localities have advantages. After more than 30 years’ FDI attraction in Vietnam, some provinces have achieved the impressive achievements in the FDI attraction. Therefore, the summary research to draw out the core success factors in the FDI attraction helps the strategic planning in attracting the FDI and preparing for the rapid implementation of FDI projects, as well as appropriate macroeconomic policies. This study is designed from a management perspective, focusing on detecting, analyzing, and summarizing the core success factors in the FDI attraction in some typical provinces with the successful FDI attraction in Vietnam. The research results show that some important factors can be mentioned, including: (1) the dynamic of the provincial government, (2) the good and synchronous planning towards investment attraction in general and the FDI in particular, (3) the decisiveness in key investments, (4) the local labor resources preparation, (5) local businesses, (6) strategic partners and FDI promoters, and (7) the FDI attraction activities innovation. The results of this study can help managers in other provinces in the FDI attraction as well as macro policy designers in building strategies and policies to attract the FDI in Vietnam.
Bridging the Gap: Integrating Organizational Change Management with IT Project Delivery
Authors: Zangana Hewa Majeed , Ali Natheer Yaseen , Zeebaree Subhi R. M.
Published: September 2024

In today's rapidly evolving technological landscape, the successful implementation of IT projects is increasingly contingent upon effective organizational change management (OCM). This research paper explores the intersection of OCM and IT project delivery, proposing a comprehensive framework that integrates these two critical domains. Through a review of existing literature and analysis of case studies, we identify key challenges and best practices for synchronizing OCM strategies with IT project management processes. Our findings reveal that the alignment of OCM with IT project delivery not only enhances project success rates but also promotes sustainable organizational transformation. This integrated approach ensures that technological advancements are supported by a well-prepared workforce, thereby minimizing resistance and maximizing adoption. The paper concludes with practical recommendations for practitioners aiming to bridge the gap between OCM and IT project delivery, ultimately fostering a more agile and resilient organizational environment.
Feature Extraction Analysis for Diabetic Retinopathy Detection Using Machine Learning Techniques
Authors: Costaner Loneli , Lisnawita Lisnawita , Guntoro Guntoro , Abdullah Abdullah
Published: September 2024

Diabetic retinopathy is a serious complication of diabetes that can lead to blindness if not detected and treated early. Automated detection of diabetic retinopathy requires effective feature extraction techniques to enhance diagnostic accuracy. This study aims to develop a method for detecting diabetic retinopathy by utilizing Local Binary Pattern (LBP) combined with wavelet transform, and then classifying the extracted features using Support Vector Machine (SVM). The approach includes feature extraction from retinal images using LBP and wavelet transform. The extracted features are subsequently classified with SVM to evaluate performance in detecting diabetic retinopathy. Analysis results show that the dominant feature is found in the fifth row with a value of 0.57006, indicating the effectiveness of the LBP method in feature extraction. The developed model demonstrates high performance with an accuracy of 95.59%, precision of 96%, recall of 97.96%, and F1-score of 96.97%. The combination of feature extraction methods with SVM proves to be effective and reliable in detecting diabetic retinopathy, offering low error rates and high accuracy, thus potentially serving as a valuable tool in clinical diagnosis
A CASE-CONTROL STUDY OF HEMATOLOGICAL ANALYSIS ON DIABETES AND COVID-19 SEVERITY
Authors: Ahmad Ghiffari  , Hartanti Miranti , Ivanka Agnes , Permana Adhi
Published: September 2024

This study investigates the relationship between diabetes comorbidity and COVID-19 severity in Muhammadiyah Palembang Hospital, focusing on hematological parameters as potential predictors of disease progression. Utilizing a case-control design with 61 respondents, demographic data, COVID-19 severity classifications, and hematological profiles were analyzed. Results reveal a prevalence rate of diabetes mellitus among COVID-19 patients at 32.8%, with diabetic individuals experiencing higher rates of moderate clinical complications. Hematological analysis demonstrates variations in parameters such as hemoglobin levels, platelet counts, and neutrophil-to-lymphocyte ratio between diabetic and non-diabetic COVID-19 patients. These findings underscore the importance of tailored interventions for diabetic individuals infected with COVID-19 and highlight the potential of hematological parameters in predicting disease severity. The study suggests the need for larger-scale, multicenter research to validate findings and inform evidence-based clinical practice in managing COVID-19 patients with comorbid diabetes mellitus.
CORRELATION OF T-CELL LYMPHOMA SUBTYPES WITH ANEMIA AT DR MOHAMMAD HOESIN HOSPITAL PALEMBANG 2018-2022
Authors: Murti Krisna , Saputra Naibaho Oldyo , Farah Diba Masayu , Kartika Edi Poedjo Purnamawati Ika , Fauziah Kurniawaty Nyiayu
Published: September 2024

Lymphoma is divided into Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). Among NHL T-cell lymphoma is a rare malignancy of T cells, accounts for 12% of all NHL cases, it is further classified into 53 subtypes by WHO. T-cell lymphoma generally have worse prognosis than those B cells. In 2020 there were 16.125 new cases in Indonesia with 9.024 deaths for all ages and genders. Anemia occurs in some cases of lymphoma, which will make the prognosis of lymphoma worse. This study aims to determine the relationship between T-cell lymphoma subtype and anemia. This observational analytic study utilized a cross-sectional design conducted at the Department of Anatomic Pathology Faculty of Medicine Sriwiaya University/Dr. Mohammad Hoesin Palembang Hospital (RSMH) and the central laboratory of RSMH. The samples from this study were all patients who were diagnosed histopathologically and immunohistochemically as T cell lymphoma at RSMH Palembang from 2018 to 2022. Among 38 samples, T-cell lymphoma predominated in the age group <55 years (73,7%), male gender (73,7%), extranodal location (73,7%), and ENKTCL, nasal subtype (55,3%). Anemia occurred in 60,5% cases and most often it is mild anemia (60,9%). There was no significant correlation between T-cell lymphoma subtype and anemia status (*p = 0.178) and T-cell lymphoma subtype and anemia degree (*p = 0.342). It can be concluded that there is no significant correlation between the T-cell lymphoma subtype and anemia.
ANALYSIS BETWEEN KNOWLEDGE AND ATTITUDES OF PARENTS REGARDING PROVIDING DOUBLE IMMUNIZATION AT THE MINASA UPA COMMUNITY HEALTH CENTER
Authors: Zabir Nur Azizah , Jalaluddin Syatirah , Rahim Rosdianah , Iip Larasati  , Fatmawati
Published: September 2024

Immunization is the act of providing immunity against a disease by introducing specific substances into the body. The completeness of immunization can be influenced by several factors such as knowledge, attitudes, number of children, health worker attitudes, family support, distance from home, education, socio-cultural factors, and community trust. This study aims to determine the relationship between parental knowledge and attitudes toward administering double immunization in infants conducted at the Minasa Upa Community Health Center. The research method used was quantitative research with an observational analytic design with a cross-sectional approach and a non-probability sampling method with a purposive sampling technique, resulting in 85 samples. The study results found that most respondents had good levels of knowledge, with 46 respondents or 54.1%, and exhibited positive attitudes, with 43 respondents or 50.6%. The highest number of respondents who administered double immunization to infants were found to have good knowledge, accounting for 67.4%, with a P-value of 0.003. Meanwhile, the number of respondents who administered double immunization and had positive attitudes was 69.8%, with a P-value of 0.001. Based on this research, it can be concluded that there is a significant relationship between parental knowledge and attitudes towards the administration of double immunization in infants.
OCTREOTIDE FOR TREATMENT RECURRENT HYPOGLYCEMIA INDUCED BY SULFONYLUREA: A CASE REPORT AND LITERATURE REVIEW
Authors: Yuddy Imowanto  , Taufiq Abdullah  , Tanjoyo Hartadi
Published: September 2024

Overdose can cause hypoglycemia, which is unresponsive to dextrose treatment alone. Octreotide, though not universally used, is an antidote for sulfonylurea overdose. We present a case report of a 62-year-old male who mistakenly consumed six tablets of sulfonylurea (Glibenclamide®), thinking they were loperamide for diarrhea. He developed dizziness, diaphoresis, vomiting, and unconsciousness. Physical examination revealed a GCS of 225, blood pressure of 188/79 mmHg, heart rate of 85 bpm, respiratory rate of 24/min, and oxygen saturation of 99%. Blood results showed RBS at 13 mg/dl, normal CBC, unremarkable blood gas analysis, hypokalemia at 2.87 mmol/l, and normal RFT and LFT. The patient was treated with bolus Dextrose 40%, maintenance Dextrose 10%, and hydrocortisone 100 mg, but blood sugar remained refractory for 1 hour despite increasing glucose infusion. After 5 hours without satisfactory results, we administered the first dose of octreotide (50 IU IV), resulting in a hypoglycemic interval lasting 2.5 hours. After a second dose of 50 IU octreotide, hypoglycemia was resolved. The patient was moved to the general ward and survived. In this case, octreotide extended the interval of hypoglycemia and reduced the need for dextrose. Using octreotide for conditions other than sulfonylurea overdose is not recommended.
PHARMACODYNAMIC OF METFORMIN IN TYPE 2 DIABETES MELLITUS PATIENTS: REVIEW OF THE PRKAA2 AND SLC22A3 GENES
Authors: Sakura Muhammad Tola  , Sultana MH Faradz  , Ahmad Rusdan Handoyo Utomo  , Samsul Mustofa
Published: September 2024

Type 2 diabetes mellitus (type 2 DM) is a disease including on metabolic disorder that characterized by an increase in glucose levels above normal. This glucose increase is caused by reduced insulin function which can be in the form of abnormalities in insulin secretion, impaired insulin action in peripheral tissues, or both. Metformin is one of the recommended therapies for type 2 DM. AMPK is the main pathway of metformin's mechanism. AMPKa2 encoded by PRKAA2 gene is an AMPK subunit that plays an important role in AMPK activation. OCT3 encoded by SLC22A3 plays a role in the metformin transport mechanism. OCT3 is needed in the metformin pharmacokinetic like absorption and elimination, this process determines metformin bioavailability, clearance, and its pharmacological effects. Mutations in PRKAA2 and SLC22A3 cause variations in the pharmacodynamic effects and pharmacokinetic of metformin in individuals directly. These changes will ultimately affect the effectiveness of metformin in type 2 DM patients.
Identification of bio-markers for insulin resistance and sensitivity through multi-omics analysis
Authors: Yet İdil
Published: September 2024

Aims: This study aims to identify multi-omics bio-markers for insulin resistance and sensitivity using machine learning approaches on a dataset integrated from several omics.
Methods: The study included 362 patients with Insulin Resistance and Insulin Sensitivity from the Integrative Personal Omics Profiling (iPOP) database. Combining the multi-omics data from the Integrative Human Microbiome Project, this study used machine learning to reveal the relationship between insulin resistance and insulin sensitivity.
Results: Of 362 patients 186 were insulin resistance and 176 were insulin sensitivity. 11,585 features were used, including clinical features, RNA transcripts, gut microbiota, cytokines, proteins, and metabolomics. We found 21 features capable of distinguishing insulin resistance from insulin sensitivity using a well-known artificial neural network (ANN) method. The model had an area under the receiver operating characteristic (AUC) of 0.97 in the validation dataset and 0.89 in the test dataset. The ANN model’s performance was compared with Random Forest model. Of the 21 new findings, two metabolites (methyl-uric acid and methylxanthine) are xenobiotics, and three RNA transcripts (SERPINF1, SLC2A2, and CHL1).
Conclusion: A small number of multi-omics features identified from 11,585 potential candidates for a machine learning model can accurately predict insulin resistance and sensitivity.
Flaps of the abdominal wall
Authors: Çırak Alaz , Sert Gökhan , Üstün Galip Gencay , Uzun Hakan
Published: September 2024

Objective: The deep inferior epigastric artery perforator (DIEP) and transverse-vertical rectus abdominis myocutaneous (TRAM, VRAM) flaps are derived from the anterior abdominal wall and can be free or pedicled. This study aimed to analyze the differences in postoperative complication rates among various types of abdominal flaps and to assess the impact of chemotherapy (CT) and radiotherapy (RT) on surgical outcomes.
Materials and Methods: A retrospective study was conducted, analyzing abdominal flap operations performed between 2016 and 2023. Data on demographics, defect location, mesh use, and postoperative chemo-radiotherapy were collected. Quantitative variables were evaluated as means, minimum-maximum values, and categorical variables were assessed as percentages.
Results: A total of 37 patients underwent 38 operations. Of these, nine patients had pedicled TRAM flaps, 16 had free-TRAM flaps, 6 had free DIEP flaps, and 6 had VRAM flaps. The defect locations were predominantly for breast reconstruction (81.08%), followed by head and neck (8.1%), extremity (8.1%), and thoracic wall (2.7%). The overall donor site complication rate was 5.4%, and the flap site complication rate was 13.51%. The lowest donor site complications were observed in the free-TRAM and VRAM groups (0%), while the highest were in the DIEP group (16.66%). The lowest flap site complication rate was 0% in the free-TRAM group, and the highest was 33.33% in the VRAM group. Donor site complication rates were similar between the mesh-used (5.88%) and non-mesh-used (5%) groups. All donor site complications occurred in patients who received postoperative CT and RT.
Conclusion: Abdominal flaps were primarily utilized for breast reconstruction. The free-TRAM group exhibited the lowest donor and flap site complication rates, while the DIEP group had the highest donor site complication rates. Mesh use did not affect donor site complication rates. Postoperative administration of CT and RT was associated with increased donor site complications.
Professional moral courage: A necessary trait that needs attention in modern nursing
Authors:   Nursing and Midwifery School, Urmia University of Medical Sciences, Urmia, Iran, Abdollahi Reza
Published: September 2024

Presently, nurses employed in healthcare environments encounter intricate moral and spiritual dilemmas as a result of their professional responsibilities. These challenges encompass issues such as aggressive interventions for terminally ill patients, superfluous medical examinations, and instances of deceit. The findings of the study highlighted deficiencies in the quality of care provided, inequitable power dynamics within the workforce, and a deficiency in organizational backing [1-3]. Conversely, given the numerous ethical dimensions within nursing practice such as upholding human dignity, respecting rights, and adhering to ethical standards, it is evident that ethics plays a crucial role in the framework of nursing [4]. One of the important and influential aspects in the discussion of professional ethics is the courage of professional ethics [5]. Moral courage is defined as standing up for what is right and involves a steadfast commitment to moral principles despite potential risks [6]. Moral courage is a virtue that creates the ability to perform moral behavior in a person and makes him perform morally despite obstacles. Courage is one of the most valuable human personality traits and has a central role in moral life. Moral courage is one of the basic values of the nursing profession. This value was introduced with two other values, love, and respect, by the International Honorary Society of Nurses in 1922 [2].
Professional socialization in nursing students: A way to develop professional nursing values
Authors:   Nursing and Midwifery School, Urmia University of Medical Sciences, Urmia, Iran, Abdollahi Reza , Bagherzadi Aynaz ,   Department of Nursing, School of Nursing and Midwifery, Urmia University of Medical Sciences, Urmia, Iran
Published: September 2024

Professional socialization is a critical aspect in the field of nursing, as it encompasses the transformation of novice nurses into competent professionals who exhibit appropriate performance. This process holds immense significance in the growth and development of nursing students, commencing from their enrollment in nursing education programs and extending until their transition into the professional healthcare environment [1]. Nursing students in colleges are instructed on their roles and moral values, which they carry with them throughout their professional careers as a lifelong learning process [2]. Socialization plays a crucial role in equipping nursing students with the essential skills needed to effectively integrate into the nursing profession. It is considered a fundamental learning process that individuals undergo, facilitated by engaging in social interactions and embracing cultural norms within the nursing field [3]. Professional socialization is widely recognized as a key catalyst and significant determinant in the advancement of the nursing field. Enhancing comprehension of socialization processes and the obstacles encountered can facilitate the identification of effective educational approaches and clinical settings conducive to the growth of the nursing profession [4].
Strategi Visual Kosmetik Jacquelle Dalam Membangun Brand Awareness Bagi Para Cosplayer Indonesia
Authors: Chandra Edy , Wilona Vira
Published: September 2024

Porsi besaran perkembangan generasi Z semakin berkembang, salah satunya dari porsi dari  generasi Z yang menyukai ”cosplay”. Tentunya porsi dari fakta ini memberikan sebuah gambaran peluang bagi produk Jaquelle Beaute untuk memperkenalkan brand produk kepada target sasarannya(tujuan penelitian). Kenyataan ini  akan menjadi daya tarik untuk melakukan penelitian dan rencana perancangan sebuah strategi visual pada media sosial Instagram. Dengan metode penelitian kualitatif deskriptif agar dapat menghasilkan ide-ide kreatif visual yang pada akhirnya dapat meningkatkan brand awareness produk Jaquelle Beaute. Hasil yang dicapai berupa strategi verbal produk Jaquelle Beaute untuk dieksekusi dalam wujud visual.
РОЗВИТОК ЛОГІЧНОГО МИСЛЕННЯ У ДІТЕЙ СТАРШОГО ДОШКІЛЬНОГО ВІКУ
Authors: СУЯТИНОВА Катерина
Published: September 2024

Статтю присвячено розвитку логічного мислення у дітей старшого дошкільного віку. У сучасному інформаційному суспільстві, яке постійно розвивається, виникає необхідність у підготовці особистостей, здатних мислити логічно, аналізувати інформацію та приймати обґрунтовані рішення. Формування логічного мислення у дошкільному віці є важливим кроком на шляху до розвитку таких компетентностей. Старший дошкільний вік – це період інтенсивного розвитку пізнавальних процесів, у тому числі логічного мислення. Логічне мислення – це фундамент для успішного навчання в школі та подальшого життя. Тому створення ефективних методик і прийомів для розвитку логічних операцій у дошкільників є одним з пріоритетних напрямів сучасної педагогіки. Незважаючи на значний прогрес у галузі дошкільної педагогіки, проблема недостатнього розвитку логічного мислення у сучасних дошкільників залишається актуальною. Це пов’язано з низкою факторів, таких як перевантаження дітей додатковими заняттями, недостатня увага до розвитку розумових операцій під час освітнього процесу тощо. Мета роботи – висвітлення специфіки розвитку логічного мислення у дітей старшого дошкільного віку. Методологія дослідження ґрунтується на поєднанні таких теоретичних методів, як аналіз, синтез та узагальнення. Наукова новизна полягає в тому, що здійснено аналіз Базового компоненту дошкільної освіти та чинної програми «Дитина» на предмет завдань з розвитку логічного мислення. Висновки. Розвиток логічного мислення – це тривалий і багатогранний процес, який вимагає систематичної роботи з дитиною, керівництва з боку вихователя. Ігрова діяльність є найефективнішим засобом розвитку логічного мислення у дошкільників. Через гру діти засвоюють нові знання, вчаться аналізувати ситуації, робити висновки. Для успішного розвитку логічного мислення важливо створити освітньо-розвивальне середовище, яке буде стимулювати пізнавальну активність дитини.
ПРОФЕСІЙНА ДІЯЛЬНІСТЬ У ВИБОРІ СТУДЕНТСЬКОЇ МОЛОДІ (СОЦІОЛОГІЧНИЙ АНАЛІЗ)
Authors: ЯКОВЕНКО Марина , НЕЛЬГА Тетяна
Published: September 2024

У статті досліджується ряд проблем професійного становлення студентів, що відповідають запитам сьогодення. Розглядаються перспективи реалізації щодо професійної діяльності студентства та вторинна реалізація їх трудової діяльності, які відбуваються в умовах соціальної, політичної, економічної нестабільності. Проаналізовано чинники впливу на вибір спеціальності та навчального закладу, а також значущість конкретних чинників при виборі місця роботи. Висвітлено думки студентів про важливість вищої освіти у пошуку очікуваної роботи, залежність працевлаштування від навчального закладу, який закінчено найкращі варіанти та , регіональну специфіку сучасного пошуку роботи тощо. Запропоновано до розгляду форми прийнятності співпраці сучасних молодих людей з організацією/фірмою та їх плани щодо діяльності після закінчення вищого навчального закладу. Звертається увага на локацію щодо потенційної професійної реалізації студентів. З огляду на складні процеси, що відбуваються в країні, акцентовано увагу на форми підтримки держави у працевлаштуванні молодих фахівців. Стаття побудована на аналізі даних двох соціологічних досліджень, проведених одночасно авторами даної статті в травні 2024 року серед студентів Міжрегіональної академії управління персоналом (м. Київ) з метою визначити першорядні чинники процесу ствердження студентів у якості фахівця протягом навчання в академії. Ряд інформаційних блоків інструментарію було розроблено співставно. Представлені дослідження були проведені методом роздавального анкетування серед студентів молодших курсів МАУП, що охоплюють напрями підготовки з технічних, природничих, гуманітарних та соціальних наук.
منهج السُّنة النَّبوية في الحماية من الاكتفاء الجنسي
Authors: İsa Najmeddin
Published: September 2024

تتناول هذه الدِّراسة أخطر مرض وجودي يهدد البشرية بأسرها ألا وهو الاكتفاء الجنسي الذي حذَّرت منه الشَّرائع قاطبة وعلى رأسها الشَّريعة الإسلامية، خصوصاً بعد قيام كثير من المؤسسات الدَّولية والتَّشريعات الوضعية بإقراره ومحاربة التشريعات التي لا تزال تعتبره جريمة يعاقب فاعلها، وقد ساعدت الثورة التكنولوجية على تسهيل انتشاره في المجتمع الإسلامي الذي ما فتئَ يقلِّد المجتمع الغربي في شذوذه الأخلاقي وخروجه عن جادَّة الفطرة الإنسانية، ليصبح هذا الانحراف السلوكي مألوفاً لدى أبنائه بعد أن ألغى تطبيق عقوبته في الشريعة الإسلامية واقتصر على عقوبة تعزيرية بديلة وفقاً للقانون الوضعي، وتكمن إشكالية البحث في انقلاب الفطرة الإنسانية وانحرافها عن مقصدها التي خلقت له في آخر الزمان من مسيرة الأمة الإسلامية لضعفها وتسرُّب فواحش داء الأمم الخبيثة إليها، ويقرر ذلك كله إعجاز خبري نبوي غيبي بيَّنته السُّنة النبوية، واستهدفت الدراسة التنبيه إلى الآثار المدمرة لهذا الداء الخبيث الذي نظمته التشريعات الفاسدة باسم حرية الإنسان في ممارسة حقِّه الشخصي في تصريف شهواته، وتعتمد الدراسة المنهج (الوصفي) التحليلي نظراً لطبيعة البحث من حيث استقراء مادته العلمية في السُّنة النبوية وإسقاطها على واقع المجتمع الإسلامي.
Nutrition Culture in the Socio-Cultural Environment in which The Prophet Muhammad’s Lived: The Example of Carbohydrate-Heavy Foods
Authors: Şimşek Ayşe
Published: September 2024

Nutrition is one of the most important elements in sustaining human life. Proper food consumption is shaped by the interaction of many factors such as geography, religion, habits, culture and economy. Foods contain many nutrients, including carbohydrates, proteins, fats, vitamins and minerals. Different types of food contain different amounts of these elements; some may be high in carbohydrates, while others may be high in protein or fat. This study deals with the definition and classification of nutrients and emphasizes the importance of a healthy diet. A balanced intake of nutrients is important for a healthy diet. The aim of the study is to determine the foods that the Prophet Muhammad (pbuh) consumed mainly carbohydrates. It is aimed to determine the nutritional culture of that period in terms of carbohydrate-based foods produced and consumed in the period and region where he lived. In this research, problem identification, data collection, data analysis and evaluation methods were applied. The carbohydrate amounts of foods were listed based on the sources on nutrition and it was investigated whether these foods were included in the Prophet’s diet. During the study, the main historical and hadith sources were identified specifically for these foods. The foods rich in carbohydrates in the Prophet’s daily diet are bread, dates, grapes, figs, honey and some vegetables. It is hoped that this study, which looks at the Prophet’s diet from a different perspective, will provide ideas for future research. The study can be seen as an example of how different disciplines such as siyar and general nutrition can work in harmony with each other.
Dil Teorileri ve Arapçanın İkinci Dil Olarak Öğretilmesinde Bu Teorilerden İstifade Edilmesi
Authors: Hamad Mutassem
Published: September 2024

Bu araştırma, ikinci dil öğrenme ve öğretme konusundaki en önemli teorileri ana hatlarıyla tanıtmayı ve Arapçanın yabancı dil olarak öğretilmesinde bu teorilerden nasıl yararlanılabileceği konusunu ortaya koymayı amaçlamaktadır. Ayrıca Arapça öğretiminde uzman olmayan öğretmenlerin veya söz konusu teoriler hakkında yeterli bilgiye sahip olmayan öğretmenlerin bilincini arttırmayı hedeflemektedir. Zira birçok çalışmaya göre Arapça öğreniminde ve öğretiminde yaşanan zorlukların sebebi, öğretmenlerin bu konuda yeterince bilgi sahibi olmamasıdır. Bu teorilere vâkıf olmak, öğretmenlerin “ikinci dil olarak Arapça ve işlevi” mefhumunu yeniden değerlendirmelerine, iyi bir öğretimin ne olduğu konusundaki varsayımlarını netleştirmelerini sağlayacak, öğretim yöntemlerini ve yaklaşımlarını geliştirmelerine yardımcı olacaktır. Dil öğretiminin en iyi yöntemi, araştırmacının bu alanda itimat edilen ilke, teori ve yöntemler hakkında dikkatli incelemeler yapması, bunları deneyimleyerek tecrübe kazanması, bu inceleme ve tecrübeler sonucunda belirli kavramları ortaya çıkarıp kendisinin oluşturduğu teori ve yöntemdir. Çünkü, teorik noktalar bilinmeden dilin etkileyici bir şekilde öğretilmesi mümkün değildir. Ayrıca bu anlayış, araştırmacının uygun öğretim yöntemlerini seçebileceği bir esas teşkil edecektir. Öte yandan; mevcut ilke, teori ve yöntemlerdeki benzer ve farklı noktaların anlaşılmasını sağlayan kapsamlı ve bütüncül bir bakış açısı sağlamak, bu yönde bir teori üretmek araştırmacının sorumluluğundadır. Bu bakış açısıyla araştırmacının, ikinci dil (Arapça) öğretimine elverişli, kapsayıcı ve olgunlaşmış bir teori ve yönteme ulaşması mümkün olacaktır.
Pengaruh Waktu Iradiasi Ultrasonik dengan Aktivasi Kalium Hidroksida terhadap Sifat Fisis Karbon Aktif dari Serbuk Karet End Life Tire
Authors: Arifin Uma Fadzilia , Adetya Nais Pinta , Pambudi Wisnu , Listyalina Latifah , Ratnaningsih Wahyu
Published: September 2024

Processing End Life Tire (ELT) rubber powder into activated carbon is an alternative for handling tire waste. One way to improve physical properties such as proximate characteristics, surface area and pore diameter of activated carbon is through chemical activation assisted by ultrasonic irradiation. This research aims to determine the effect of ultrasonic irradiation time with potassium hydroxide (KOH) activation on the quality of ELT rubber activated carbon. Activated carbon was synthesized and activated using 30% KOH at various ultrasonic irradiation times, namely 0 minutes, 15 minutes, 30 minutes, 45 minutes and 60 minutes. Based on the characterization results, activated carbon with an ultrasonic irradiation time of 30 minutes is the active carbon that has the most superior properties. The proximate characteristics of activated carbon meet the active carbon quality requirements of SNI 06–3730–1995 and have the highest surface area, namely 401.11 m2/g and pore diameter of 2.1652 nm, which is included in the mesoporous structure category so that it has the potential to be applied as an adsorbent for heavy metals from contaminated fluid.
Pengaruh Konsentrasi Enzim, Ragi, dan Lama Fermentasi terhadap Pembuatan Bioetanol Berbahan Baku Chlorella pyrenoidosa
Authors: Jannah Asyeni Miftahul , Wahyuni Indah , Amalia Renanda , Savrinda Cynthia , Hani Indry Permata
Published: September 2024

The demand for energy is inversely proportional to the current amount of energy in Indonesia. In order to face this problem, it is necessary to develop renewable energy sources. This study was conducted to analyze enzymes effect in the Chlorella pyrenoidosa hydrolysis, analyze yeast effect and the fermentation time of Chlorella pyrenoidosa on the bioethanol produced. The variables used are variation of α-amylase enzyme concentration of 25%, 35%, 45% (v/w), and variation of yeast concentration of 5%, 10%, 15% (w/v) and fermentation time of 7, 9, 11 days. From the analysis conducted, the highest glucose content was 13.119%, which was in the variation of 45% (v/w) α-amylase enzyme concentration. The amount of enzyme concentration used was in accordance with glucose production. The highest bioethanol was obtained with a sample involving 10% (v/b) yeast fermented for 9 days, which amounted to 27%.
Penentuan Kadar Flavonoid dan Kandungan Fitokimia Ekstrak Kulit Bawang Merah (Allium cepa L) dengan Berbantukan Microwave sebagai Potensi Bahan Aktif Tabir Surya
Authors: Dalimunthe Nisaul Fadilah , M. Thoriq Al Fath  , Taslim  , S. Ginting M. Hendra , Farah Nurul Alifia  , Berta Grace Adela
Published: September 2024

The skin serves as a protective barrier against dust and ultraviolet (UV) radiation. Excessive UV exposure is associated with accelerated skin aging, erythema, hyperpigmentation, and carcinogenesis. This study aimed to quantify flavonoid concentrations and characterize phytochemical constituents in shallot skin extracts for their potential as active ingredients in sunscreen formulations. Shallot skin was subjected to microwave assisted extraction using 70% ethanol as the solvent. Phytochemical screening revealed the presence of flavonoids, tannins, saponins, and alkaloids in the extract. Flavonoid content was determined via UV-Vis spectrophotometry, yielding 36.33 mgQE/g. The high flavonoid concentration observed in shallot skin extract suggests its potential efficacy as an active ingredient in sunscreen formulations.
Ekstraksi Daun Kejibeling (Strobilanthes crispus) dengan Metode Continuous Ultrasound-Assisted Enzymatic Extraction: Pengaruh Temperatur dan Konsentrasi Enzim
Authors: Sitorus Randi , Tania Surya Utami  , Yuswan Muharam  , Rita Arbianti  , Naufal Azrizal Prasetyo
Published: September 2024

Continuous ultrasound-assisted enzymatic extraction (CUAEE) method has become a promising technique for extracting bioactive compounds from plant materials. In this study, the extraction of kejibeling (Strobilanthes crispus) leaves was carried out using the CUAEE method to optimize the extract yield. The experimental design involved extraction parameters including leaf particle size (d ≤0,177 mm), ethanol concentration (50%), extraction time (180 minutes), and varying parameters such as temperature (30 °C, 40 °C, 50 °C, and 60 °C), as well as cellulase enzyme concentration of 3% and 5%. The results showed that the optimal conditions for CUAEE were achieved at a temperature of 60 °C with an enzyme-solid ratio of 5%, producing a total phenolic content (TPC) of 12,097 mg EAG/g dry leaf powder and a total flavonoid content (TFC) of 2,291 EK/g dry leaf powder. The data obtained indicate that the continuous ultrasound-assisted enzymatic extraction method has the potential for large-scale production of phenolic acids and flavonoids.
Analisis Potensi dan Ketimpangan Pembangunan Kabupaten/Kota di Provinsi Kepulauan Riau
Authors: Candrawati Cindy , Aji Nugroho Alih
Published: September 2024

Ketimpangan merupakan masalah yang disebabkan oleh pembangunan yang tidak merata. Pemekaran wilayah menjadi salah satu alternatif solusi untuk mengatasi masalah ini melalui pemanfaatan potensi di setiap wilayah. Di Provinsi Kepulauan Riau, ketimpangan terlihat dalam proses pembangunan, dengan Kota Batam menunjukkan indeks pembangunan tertinggi di berbagai sektor dibandingkan dengan enam kabupaten/kota lainnya. Kajian literatur, serta studi pengukuran potensi dan ketimpangan, menunjukkan bahwa analisis Location Quotient mengindikasikan adanya peningkatan sektor basis di beberapa kabupaten di Provinsi Kepulauan Riau. Data Koefisien Gini juga menunjukkan tren penurunan ketimpangan selama satu dekade terakhir. Meskipun demikian, masih terdapat disparitas pendapatan per kapita yang besar di Provinsi Kepulauan Riau, seperti terlihat dalam koefisien variasi dan Indeks Williamson.
Kata Kunci : Ketimpangan Pembangunan, Potensi Daerah, Pemerataan, Indeks Gini
Violencias y precarización. Experiencias en torno a relatos biográficos juveniles
Authors: Salazar Gutiérrez Salvador , Carreras Rafael Antonio , Martínez Ochoa Hugo , Abraham Sepúlveda Nahir Florencia , Rebollo Santiago , del Carpio Sol Victoria , Lamanuzzi Sofía , González Paula Daniela , Pruneda Paz Guillermina , Espinosa María Candelaria , Bard Wigdor Gabriela , Soria Ana Sofía , Curetti Caren Eliana , Ochoa Valor María Victoria , Scoles Antonella , Muro Garlot Julio Luis , Volando María Victoria , Ardiles María Belén , Paulín Horacio Luis , García Bastán Guido , D'Aloisio Florencia , Arce Castello Valentina , Caparelli María Florencia , Sicot Sofía Natalia , Zurbriggen Ayelén Rocío , Castro Julieta Natalia , rancio Julieta A , Arias Lucía Angélica , Duarte Quapper Claudio Orlando , Farías Mansilla Francisco Antonio , Hernández Mary Natalia Evelyn
Published: September 2024

Los jóvenes de Latinoamérica viven entornos diversos y contradictorios, muchas veces sentados en un proyecto adultocéntrico, heteropatriarcal y racializado, donde se vive violencia de género, violencia institucional, narcotráfico, pobreza y exclusión. En este contexto de precariedad social, esta obra coloca su centro de atención en el relato biográfico de jóvenes en lugares como Ciudad Juárez, México; Córdoba, Argentina, y Santiago, Chile, donde se muestra cómo se articula la experiencia juvenil con estos escenarios sociales. En ese sentido, surgen las preguntas: ¿Desde dónde hablan los jóvenes?, ¿qué particularidades adquiere el lugar desde el cual entretejen sus múltiples experiencias de vida?, que son desmenuzadas en los trabajos aquí presentados.
Harry Brailovsky y su relevancia como taxónomo en tiempos modernos
Authors:   Universidad Nacional Autónoma de México, Pérez Hernández Cisteil X.
Published: September 2024

Presento aquí un reconocimiento a la trayectoria académica de Harry Brailovsky, quien ha tenido una prolífica carrera dedicada principalmente a la sistemática y taxonomía de Heteroptera (Insecta: Hemiptera), en la Colección Nacional de Insectos, Instituto de Biología, de la Universidad Nacional Autónoma de México. Hasta hoy, Brailovsky ha descrito 1115 taxones, entre los que se cuentan tres tribus, 149 géneros y 963 especies de hemípteros; ha publicado alrededor de 400 trabajos como artículos, libros y capítulos, en los que ha descrito casi el 1% del total de especies de hemípteros conocidas en todo el mundo. Brailovsky ha sido investigador durante los últimos 48 años, y desempeñó el cargo de Curador General de la Colección Nacional de Insectos durante tres décadas. Actualmente, el impacto de su trabajo es relevante tanto para la Entomología como para la Sistemática, a escala nacional e internacional.
Intersections of Aging and Immigration: The Promise and Paradox of a Better Life
Authors: Guruge Sepali
Published: September 2024

This book examines the intersections of aging and immigration in Canada, examining the unique challenges faced by older immigrants. Section 1 introduces critical issues related to aging and immigration, highlighting health disparities shaped by social determinants such as gender, racism, and access to services. Chapters 1 and 2 explore how these structural barriers affect the health and well-being of older immigrants, with a focus on social exclusion and systemic inequities. Section 2 discusses the health statuses of older immigrant women and men, emphasizing the need for culturally tailored services. Section 3 addresses socioeconomic factors like social isolation and housing insecurity, illustrating how older immigrants navigate these challenges in Canada. Section 4 focuses on caregiving, examining family care partners' roles and the mismatches between caregiver needs and available support. Section 5 tackles service access, identifying key barriers and exploring potential interventions for improving elder care in immigrant communities. Section 6 concludes by addressing research and policy considerations, particularly the importance of inclusive, community-based research and the role of social infrastructure in promoting well-being. Together, these sections provide a comprehensive understanding of the multifaceted experiences of older immigrants in Canada, urging for systemic change and more equitable support structures.