bluuebunny/crossref_metadata_2025 huggingface dataset:
FAKTOR YANG MEMPENGARUHI HASIL PENJUALAN USAHA DODOL DI DESA PASAR BENGKEL KECAMATAN PERBAUNGAN KABUPATEN SERDANG BEDAGAI
Authors: Lumban Gaol Aprialicia
Published: June 2022

This study aims to analyze the effect of capital, labor, and length of business on dodol sales results. The sample in this study was 46 business actors based on predetermined criteria using the random sampling method. The data analysis technique used is multiple linear regression analysis using the SPSS version 23 application. The results of this study indicate that capital, labor, and length of business have a positive and significant effect on the sales of Dodol Business in Pasar Bengkel Village, Perbaungan District, Serdang Bedagai Regency. In the test of the coefficient of determination before the toll road that the capital, labor, and length of business is 0.787. So this means that sales results can be explained by capital, labor, and length of business by 78.7% and the remaining 21.3% is influenced by factors not examined. And after the toll road, it shows that the capital, labor, and length of business are 0.872. So this means that sales results can be explained by capital, labor, and length of business by 87.2% and the remaining 12.8% is influenced by factors not examined. Thus the linear regression model can be considered appropriate.
UPAYA PENINGKATAN KEMAMPUAN MENULIS SURAT UNDANGAN MELALUI METODE DRILL KELAS XII IPA 1 MA USB FILIAL MAN BATAM
Authors: PETRIAS HAWINADA
Published: June 2022

The purpose of this study was to describe the ability to write invitation letters through the DRILL method for Class XII IPA 1 MA USB Filial MAN Batam. There are two kinds of data collection techniques in this study, namely: (l) Non-test Techniques, and (2) Test Techniques. The results showed an increase in the ability to write invitation letters in the first cycle the average achievement of class results was 84.00% consisting of: invitation letter systematics 29.00% sentence effectiveness 33.50% and spelling 21.50%. So in the first cycle there were 34 students or 85% completed. In the second cycle the average achievement of class results was 93.30% consisting of: invitation letter systematics 30.00% increased 1.00% from cycle I, sentence effectiveness 39.70% increased 6.230% from cycle I, while spelling 23 ,60% increased by 2.10% from the first cycle and 44 students or 100% completed. When compared from the initial data, the average achievement of class results is 63.68% consisting of: systematic 21.58%, sentence effectiveness 23.95%, and spelling 18.68%, and 8 students or 23% who completed, so It is clear that with the Drill method, the students' ability to write invitation letters has improved very well and quickly.
ABSTRAKTujuan penelitian ini adalah untuk mendeskripsikan kemampuan menulis surat undangan melalui metode DRILL Kelas XII IPA 1 MA USB Filial MAN Batam. Teknik pengumpulan data dalam penelitian ini dua macam teknik, yakni: (l) Teknik Nontes, dan (2) Teknik Tes. Hasil penelitian menunjukan peningkatan kemampuan menulis surat undangan pada siklus I rata- rata pencapaian hasil kelas 84,00% yang terdiri dari: sistematika surat undangan 29,00% keefektifan kalimat 33,50% dan ejaan 21,50%. Jadi pada siklus I ada 34 siswa atau 85% tuntas. Pada siklus II rata- rata pencapaian hasil kelas sebesar 93,30% yang terdiri dari: sitematika surat undangan 30,00% naik 1,00% dari siklus I, keefektifan kalimat 39,70% naik 6,230% dari siklus I, sedangkan ejaan 23,60% naik 2,10% dari siklus I dan 44 siswa atau 100% tuntas. Kalau diperbandingkan dari data awal yang hanya rata- rata pencapaian hasil kelas 63,68% terdiri dari: sistematika 21 ,58%, keefektifan kalimat 23,95%, dan ejaan 18,68%, dan 8 siswa atau 23% yang tuntas, jadi jelas dengan metode Drill kemampuan menulis surat undangan yang pada siswa meningkat sangat baik dan cepat.
MENINGKATKAN HASIL BELAJAR PENGUASAAN KOSAKATA BAHASA INGGRIS MELALUI PENGGUNAAN MODEL MAKE A MATCH
Authors: WARDAH WARDAH
Published: June 2022

This study was carried out with the aim of analyzing the use of the Make a Match learning model in an effort to improve student learning outcomes in english vocabulary. The subjects in this study were class VIIA students of SMP Negeri 16 Hulu Sungai Tengah which totaled 22 people consisting of 8 men and 14 women. Data on student learning outcomes in this study were obtained through the results of the final test using multiple choice questions (Multiple Choice Test). Data on student learning outcomes were analyzed descriptively based on test scores and student learning completion, using the Make a Match model in learning showed an increase in student learning outcomes which was shown by an increase in the average grade point from 70.90 in cycle I to 86.36 in cycle II, for learning completion also increased, judging from the individual completion of 17 students in cycle I increased to 21 students in cycle I. Likewise, judging from the presentation of classical learning completion from 77.27% cycleD I increased to 95.45% cycled II, so it can be concluded that this Make a Match learning model can improve student learning outcomes in mastering English vocabulary.
ABSTRAKPenelitian ini dilaksanakan dengan tujuan untuk menganalisis penggunaan model pembelajaran Make a Match dalam upaya untuk meningkatkan hasil belajar siswa pada pengasaan kosakata bahasa inggris. Subjek pada penelitian ini adalah siswa kelas VIIA SMP Negeri 16 Hulu Sungai Tengah yang berjumlah 22 orang yang terdiri dari 8 orang laki-laki dan 14 orang perempuan. Data tentang hasil belajar siswa pada penelitian ini diperoleh melalui hasil tes akhir dengan menggunakan soal pilihan ganda (Multiple Choice Tes). Data tentang hasil belajar siswa dianalisis secara deskriptif berdasarkan nilai tes dan ketuntasan belajar siswa, dengan menggunakan model Make a Match dalam pembelajaran menunjukan adanya peningkatan hasil belajar siswa yang ditunjukan dengan adanya peningkatan nilai rata-rata kelas dari 70,90 pada siklus I menjadi 86,36 pada siklus II, untuk ketuntasan belajar juga mengalami peningkatan, dilihat dari ketuntasan secara individual dari 17 orang siswa pada siklus I meningkatkan menjadi 21 orang siswa pada siklus I. Demikian juga dilihat dari presentasi ketuntasan belajar secara klasikal dari 77,27% disiklus I meningkat menjadi 95,45% disiklus II, sehingga dapat disimpulkan bahwa model pembelajaran Make a Match ini dapat meningkatkan hasil belajar siswa pada penguasaan kosakata Bahasa Inggris.
The Intersection between GIScience and History: an Overview of an Emerging Scientific Field
Authors: Meyer Hannah , Scholz Johannes
Published: June 2022

Abstract. Using the methods of Geographic Information Science and Technology (GIS&T) to analyze historical data has been of increasing interest to the scientific community of History in the last two decades. The spatial turn in the Humanities fueled this development and lead to a number of scientific initiatives that utilized GIS&T to store, analyze and visualize historical data accordingly. This article, documenting ongoing work, outlines the scientific developments, main research foci, and past and current research interests of the emerging field of historical GIS from the beginning of the spatial turn in the social sciences to the present day. The article is using a literature review in the fields of Geographic Information Science and History as core methodology. Our main findings are centered around the fact that historical GIS research is spread out over a variety of disciplines and journals. Hence, building a methodological and theoretical core, and forming cohesion in the field has been challenging. Current research trends underpin this trend. Nevertheless, a number of promising research initiatives are pursued at the intersection of GIS&T and History – which documents an intensification of the collaboration between both fields.
Geospatial technologies for an automated holistic risk assessment of UAS operations
Authors: Paulus Gernot , Strelnikova Dariia , Lutz Thomas , Anders Karl-Heinrich , Gäbler Klaus , Lippitsch Gerhard , Meier Daniela , Eisenbach Stefan
Published: June 2022

Abstract. The rising number of UAS operations in the European airspace poses a safety issue. The key problem is to ensure safe drone traffic management and their integration into the existing air traffic environment. Thus, risk assessment becomes an integral part of every UAS operation and its automation is of great importance when dealing with growing numbers of flights. There exist many attempts to support such risk assessment, but an optimal solution is yet to be found. This paper presents a prototype of a web application, which automates strategic risk assessment of open and specific UAS operations in Austria with the use of open government geodata. Risk assessment results are visualized on a map, showing spatial distribution of classified risks in the operational area. This prototype is the first attempt to combine the functions of a “drone map” representing relevant geodata and a questionnaire usually used to support specific operation risk assessment. There is a potential to turn it into a tool which is used to create a comprehensive pre-flight safety portfolio or to support the automatic risk assessment performed by a UTM before a UAS operation is checked in. Simplifying the creation of safety portfolios and automating UAS operation risk assessment are important factors in promoting a wider and safer use of UAS.
Flood modelling and proposed Blue-Green Solutions – A case study in Lisbon, Portugal
Authors: Arnsteg Alexandra , Glinski Juliane , Marijauskaite Patricija , Nitschke Annika , Olsson Marianne , Pierre Agnes , Rosenquist Ohlsson Lovisa , van der Vleuten Sacha , Pilesjö Petter
Published: June 2022

Abstract. This study assesses the potential benefit of Blue-Green Solutions (BGS), green rooftops, rain gardens, permeable pavements, and bioswales, in Lisbon, Portugal. These proposed mitigation measures are applied using TFM-DYN (Nilsson et al., 2021) to simulate potential fluvial flooding distributions from a 10- and 50-year rain event.Water depth of over 30 centimeters can cause damage to infrastructure. The model results show water depths of over 40 centimeters in some parts of the study area for the 10-year return period, raising the need for action. For the 50-year return period even more areas will be affected. These floods can occur at a relatively rapid pace. Four BGS were implemented for flood mitigation. Areas with green roofs and rain gardens showed a lowering in water depth for both return periods. This study shows that even relatively simple data allows for an estimation of urban flooding and the potential effect of BGS for specific locations can easily be determined.
When is a Ring Road a ’Ring Road’? A Brief Perceptual Study
Authors: Potié Quentin , Mackaness William A. , Touya Guillaume
Published: June 2022

Abstract. The shapes and patterns of the road network of a topographic map provide important visual cues when interpreting the map and moving between scales in interactive environments. The ’city ring road’ is an example of a road structure we might use in the recognition and characterisation of a city. Our goal is the automatic identification (and preservation) of such structures through changing scales. In this preliminary study, we conducted an online survey and face to face interviews in order to obtain and prioritise the structural, topological and semantic properties that define ’ring road-ness’. We then created a practical ontology of ring roads, with a view to algorithm implementation that mirrors the human perception of ring roads.
Acceleration of Human Resource Development for the UAV data processing in Indonesia
Authors: Tampubolon Winhard , Reinhardt Wolfgang , Behr Franz-Josef
Published: June 2022

Abstract. Geospatial Information (GI) utilization needs acceleration in conjunction with the unprecedented improvement of GI technology infrastructures. Unmanned Aerial Vehicles (UAV) is one instance that demonstrates some advantages by enabling on demand flexible geospatial data acquisition. However due to the frequent use of non-metric camera such as consumer grade cameras, it requires the calibration procedure in order to fulfil the acceptable geometrical accuracy. The relatively simple procedures and high resolution produced data are the major advantages of the UAV data acquisition. With a land area approximately five times of the Federal Republic of Germany, the provision of GI in Indonesia requires innovative acceleration strategies that also considers cost production efficiency moreover due to the preparation of human resource in GI as its primary component. In this case, certification and accreditation in GI area are still mandatory especially in conjunction with technological improvements and weather situation (cloud coverage) as the main constraints to be considered for the geodata acquisition in Indonesia. This process includes knowledges, skills and/or advancements as well as working behaviour relevant with the tasks and conditions in a so-called Competency Working Standards of Indonesia (SKKNI). In addition to the SKKNI, GI competency standards can also use relevant international standards or specific standards as a reference. Competency standards are the basic requirements for any activities related with the national GI provision. Based on analysis of the national interests, the qualification identifications can be performed by specific study in the context of business process and GI industry from the scope of above mentioned national/international view as well as particular (GI) industry.Finally, this paper discusses and formulates the competency standards that can be used by corresponding stakeholders involved in the national GI provision from the actual regulation as well as technological/industrial perspectives. The standards of GI empowerments are fundamental especially in a situation where there are various technology and method available in the society as well as GI industry. For this purpose, the proper professional certification must be essentially well defined in order to prepare excellent GI human resources as the primary source for the provision of reliable GI data and information in a favour of the Large Scale Topographic Mapping (LSTM) and Updating acceleration program.
Mapping a historic neighbourhood through user-generated content: the case of Alfama, Lisbon (Portugal)
Authors: Tang Vicente , Puri Jaskaran , Painho Marco
Published: June 2022

Abstract. Participant-based methods aimed at extracting neighbourhood definitions are labour and time intensive. On the other hand, user-generated content (UGC) can provide locations to assess the extent of neighbourhoods. We investigated the definitions of Alfama - a historic neighbourhood in Lisbon (Portugal) - using six sources of UGC and applied a modification of the DBSCAN algorithm developed in the literature. By generating shapes from each source, we were able to visually and quantitatively evaluate their agreement as well as their differences.We demonstrate how different profiles of user activity from each source yielded varied geographies of Alfama. Although discrete representations are not the optimal choice, practical applications such as urban planning usually demand sharp definitions. Lastly, our approach can be extended and improved by adding more sources of UGC data and by picking other case studies.
Teaching geoinformatics: challenges and opportunities
Authors: Uuemaa Evelyn , Kmoch Alexander
Published: June 2022

Abstract. In this paper, we discuss new challenges and opportunities in teaching geoinformatics on a conceptual level. We pose that spatial is not special anymore from a technological point of view, but at the same time teaching spatial thinking is more challenging than ever. We summarize our key positions and conclude with a call to action to rethink how we can ensure that our teaching of core geoinformation sciences and technologies remains a strong and supportive education pillar in our modern data-driven world.
Assemble geo-analytical questions through a Blockly-based natural language interface
Authors: Xu Haiqi , Nyamsuren Enkhbold , Scheider Simon
Published: June 2022

Abstract. Natural language Interfaces (NLIs) have the ability to make Geographic Information Systems more accessible for interdisciplinary researchers or any inexperienced users. However, the majority of research on NLIs for GIS explored NLIs for visualization or spatial data retrieval. Research on NLIs for geo-analytical questions is still lacking. Google Blockly, an open-source JavaScript library, is frequently used for developing visual programming editors for young students learning programming languages. Students set up program functions by selecting and assembling the programming blocks and the Blockly system automatically translates the block stacks into different programming languages. Similarly, we present a Blockly-based interface that generates a question depending on the blocks the user has assembled. It can be seen that a Blockly-based interface not only naturally represents syntactic structures in geo-analytical questions but also well assists users in familiarizing the blocks and generating clear and complete questions. A comprehensive usability study is still necessary to better evaluate the interface’s performance.
Review: Matthias Fink, Srebrenica: Hronologija jednog genocida ili šta se desilo sa Mirnesom Osmanovićem, Dobra knjiga, Sarajevo 2020, 1119 str.
Authors:   Sarajevo, Selimović Elvir
Published: June 2022

Review: Matthias Fink, Srebrenica: Hronologija jednog genocida ili šta se desilo sa Mirnesom Osmanovićem, Dobra knjiga, Sarajevo 2020, 1119 str.
Review: Mirjana Kasapović, Bosna i Hercegovina 1990-2020: Rat, država i demokracija, Školska knjiga, Zagreb 2020, 536 str.
Authors:   Faculty of Law, University of Sarajevo, Bandžović Sead
Published: June 2022

Review: Mirjana Kasapović, Bosna i Hercegovina 1990-2020: Rat, država i demokracija, Školska knjiga, Zagreb 2020, 536 str.
THEORETICAL AND EXPERIMENTAL MODELLING OF THE TRIBOLOGICAL BEHAVIOUR ASPECTS OF CONTACT ELEMENTS IN THE PRECESSIONAL GEARING (PG)
Authors:   Technical University of Moldova, Bostan Ion , Stoicev Petru ,   Technical University of Moldova, Postaru Gheorghe ,   Technical University of Moldova, Vaculenco Maxim ,   Technical University of Moldova, Buga Alexandru ,   Technical University of Moldova, Kulev Mihail ,   Technical University of Moldova, Postaru Andrei ,   Technical University of Moldova, Platon Andrei ,   Technical University of Moldova
Published: June 2022

This paper deals with the theoretical-experimental model of the tribological behavior of the contact elements in precessional gears (PG) in the functions of conjugate profiles of linear velocities “convex-concave” or “convex-convex” for the corresponding geometric parameters (ρki, r, ρki – r) and the values of the kinematic force parameters (VE1, VE2, Vai) for each concrete position of the ki points. The calculation of the constructive-functional and kinematic parameters of the “roller-shoe” and “roller-roller” elements of the tribocouple were adjusted for the experimental verification tests on the SMT-1 installation and adapted to the specific test conditions of the tribocouples with conformal contact of gear teeth made of plastics, which will be subjected to sliding friction and rolling processes of the concrete tribocouple elements.
PEDESTRIAN SAFETY ELEMENTS REGARDING CAR CONSTRUCTION
Authors:   Technical University of Moldova, Plamadeala Vasile , Goian Vladimir ,   Technical University of Moldova
Published: June 2022

Almost a quarter of people killed in road accidents worldwide are the most vulnerable road users – pedestrians. Every year, more than 300000 pedestrians die on the world’s roads, which is about 23% of the total number of people killed in road accidents. In addition, millions of pedestrians are traumatized, some of them becoming disabled for life. The article includes a brief description of the driver-pedestrian relationship, road accident statistics involving pedestrians in the Republic of Moldova and in different geographical areas of the globe, modern practices and technologies applied in car construction by manufacturing plants to ensure pedestrian safety.
DEVELOPMENT OF SIX-PHASE SYMMETRICAL COMPONENTS FILTERS FOR SELF-COMPENSATING POWER LINES
Authors:   Institute of Power Engineering, Republic of Moldova, Turturica Natalya
Published: June 2022

The paper deals with elaboration of hexaphase symmetrical components filters and their modeling to create microprocessor-assisted relay protection of self-compensating power lines. The theory is presented and the basic principial electrical schemes and mathematical models in the Matlab/Simulink of the filters of the hexaphase symmetric components are elaborated. The results of their simulation and testing at the computer are presented. The obtained results demonstrate the possibility of creating in the base on the elaborated filters of hexaphase symmetrical components the modern, efficient and high-sensitivity microprocessor-assisted relay protection of self-compensating power lines. What reacted not to phase electrical values, but symmetrical components of them.
THE INFLUENCE OF A RESIDUAL REFLECTIVITY AT THE FRONT FACET OF A MULTISECTION MASTER-OSCILLATOR POWER-AMPLIFIER
Authors:   Technical University of Moldova, Grigoriev Eugeniu , Tronciu Vasile ,   Technical University of Moldova, Werner Nils ,   Ferdinand-Braun-Institut, Germany, Wenzel Hans ,   Ferdinand-Braun-Institut, Germany
Published: June 2022

This paper reports on the theoretical end experimental investigation of the output characteristics of a multisection master-oscillator power-amplifier (MOPA). It consists of a master oscillator (MO) composed by a gain section surrounded by two DBR sections monolithically integrated with a power amplifier (PA). We use a traveling wave equation model to calculate the optical output power in dependence on the current injected into the PA. The experimental results can be well explained with our theoretical analysis. For a finite front facet reflectivity of the PA the system is acting as a compound cavity.
SECURE SOFTWARE DEVELOPMENT AWARENESS: A CASE STUDY OF UNDERGRADUATE DEVELOPERS
Authors:   Mangosuthu University of Technology, South Africa, Mutanga Murimo Bethel
Published: June 2022

As ubiquitous computing becomes an increasingly inherent component of everyday life due to the rapid growth of communication technologies and globalization, threats against information systems have taken a more latent yet lethal dimension. This emergent digital security challenge has correspondingly motivated a proactive change in the software engineering process in recent decades. This change has inspired more intense research scrutiny on security as a crucial component of any software system. Moreover, in today’s virtual world of hyperconnectivity, the most significant vulnerabilities in modern information systems security are software centred. Nevertheless, research shows that software developers often lack the required knowledge and skills in secure software systems development (SSD). Such knowledge ensures that all the resultant software components of each development lifecycle are correctly implemented rather than merely following the SSD lifecycle. Also, the knowledge engenders software security consciousness as a professional attitude amongst developers. Therefore, investigating students’ awareness of SSD principles can generate insight into evolving the undergraduate software development curriculum – a path to building future career developers. The study used a voluntary online survey to recruit a sample of 76 undergraduate developers and employed a descriptive approach to data analysis. Among other findings, the study revealed that participants’ perception of the threat of software vulnerability impacts their attitude towards security on online and mobile platforms. And that though over 90% of the undergraduate developers took software vulnerability threats either “serious” or “extremely serious”, this disposition did not reflect the depth of their knowledge and experience in SSD.
TEMPERATURE CAPTURE AND IMAGE PROCESSING SYSTEM: A CASE STUDY
Authors:   Technical University of Moldova, Istrati Daniela
Published: June 2022

This paper describes a technical solution to stop the spread of COVID-19 by creating a system consisting of a video camera with a thermal sensor connected to a web-based platform, which would help to manage to restrict access of people who have fever into a building. The main purpose of the project system is to measure body temperature, to detect and to recognize the person that has at the moment or had fever in the past 14 days, the registration in the database of both the fever and the person, and validate the access of the person in the building if it has a temperature below 37 degrees Celsius. The technical details as analysis and determination of the domain of interest, development of the new system design, functional and non-functional requirements, interface, project planning, technical specification and quality of the proposed solution are discussed. The proposed system aims to reduce the number of employees responsible for collecting the temperature, thus no longer exposing them to the risk of infection.
TECHNOLOGICAL INNOVATIONS AS DRIVERS OF RETAIL 4.0 – HOW RFID COULD IMPROVE RETURNABLE BOTTLE LOGISTICS IN THE GERMAN BEVERAGE INDUSTRY
Authors:   Baden-Wuerttemberg Cooperative State University, Germany, Bührdel Stan Lukas , Siegfried Patrick ,   International School of Management GmbH, Germany
Published: June 2022

This research paper discusses how RFID technology could improve current deposit bottle logistic processes in food retailing and which obstacles impede successful implementations. Research Methodology include desk research: Library, EBSCOhost, wiso.net, Google Scholar, Scientific Journals, Statista, SpringerLink. Implementation of RFID is potentially beneficial, but same obstacles remain outlook. To validate the conclusion further studying and practical proof of concept are necessary. Contributions: supply chain management, return logistics, food retail, beverage industry.
A study on clinical characteristics, computed tomography brain imaging, causes and complications of subarachnoid hemorrhage
Authors: Duong Le Xuan , Minh Vu Duy , Cong Ngo Chi , Hoa Do Thanh
Published: June 2022

Backgroud: Subarachnoid hemorrhage (SAH) is sudden bleeding into the subarachnoid space. The most common cause of spontaneous SAH is a ruptured aneurysm. Symptoms include sudden, severe headache, usually with loss or impairment of consciousness. It has a lot of dangerous complications especially re-bleeding and vasospasm which are the major causes of death and disability. Objective: To study on clinical characteristics, computed tomography brain imaging, causes and complications of subarachnoid hemorrhage. Subject and method: A cross-sectional prospective study on 202 patients who suffered from subarachnoid hemorrhage admitted to the Stroke Center, 108 Military Central Hospital from June 2018 to January 2020. Result and conclusion: The average age was 60.5 years. The most common age group was among the aged 45-64 years (71.2%). The most common symptoms of SAH was sudden severe headache (98%); neck stiff (86.1%), followed by consciousness disorders (56.9%), systolic blood pressure above 160mmHg (50.5%), focal neurologic deficits (20.3%). The Fisher classification: Grade 1 (4.5%), grade 2 (17.3%), grade 3 (19.3%), grade 4 (58.9%). The ruptured cerebral aneurysm accounted for 89.6% of the causes of SAH. The most common site of aneurysm was in the anterior communicating artery (34.8%), followed by the middle cerebral artery (21.5%) and in the internal carotid artery (16.6%). Posterior cerebral circulation accounted for 12.7%; 4.4% of patients had multiple aneurysms. The most common complications of SAH was cerebral vasospasm (26.2%) and typically occurred between 5 and 7 days after SAH, followed by rebleeding accounted for 7.9%, the most cases occurred within the first 24 hours, acute and subacute hydrocephalus (10.4%), hyponatremia (11.4%) and seizures (5.4%).
Characteristics of elderly with acute poisoning at Vietnam Poison Control Center
Authors: Anh Nguyen Trung , Viet Anh Pham Thi , Xuan Dang Thi , Huyen Vu Thi Thanh
Published: June 2022

Objective: The aim of this study was to identify the prevalence and causes of acute poisonings in older people admitted to Vietnam Poison Control Center (PCC). Subject and method: A retrospective descriptive study was conducted at the PCC for 8 months in 2019 with 275 acute poisoned patients aged 60 and older. The questionnaire collected data was based on the International Program for Chemical safety (IPCS) format. Entered data on Redcap and using SPSS version 22.0 for analysis. Result: The prevalence of acute poisoning was higher in female elderly. The most common cause of poisoning was poisonous animals (44.7%). The number of elderly patients suffered from acute poisoning increased in April, July and August. Ingestion and bite were two most common routes of exposure (53.8% and 41.1%). Conclusion: Acute poisoning was common in the elderly and increased in 4th, 7th and 8th month of the year.
Posner-schlossman syndrome in Vietnam: A retrospective review study
Authors: Tien Luu Viet , Hoa Nguyen Thi , Thao Pham Minh , Giang Le Thi , Nghia Dinh Viet
Published: June 2022

Objective: To describe the characteristics of patients acquired Posner-Schlossman syndrome (PSS) in Vietnam over a 2-year period and find out the underlying causes of PSS. Subject and method: This study was a retrospective case-series analysis of the clinical charts of 31 patients diagnosed with PSS. All the patients were collected characteristic information 081 and suspected to have CMV or HSV and had undergone real-time PCR of the aqueous humour to determine whether patients have CMV, HSV-positive or CMV, HSV-negative. Result: The mean age of the patients at the initial examination was 50.2 ± 17.4 years. The mean age at the first PSS attack was 45.6 ± 11.6 years. The mean IOP was significantly higher in the affected eyes than in the unaffected eyes (p=0.02). The average BCVA (p=0.14) were lower in the affected eyes than in the unaffected eyes but not reached statistical significance. The majority of these patients were aged 20 - 60 years (64.5%). Autumn demonstrated a little bit higher onset of PSS than other seasons. 33.2% of patients with PSS revealed the CMV cause, the figure for HSV1 was 6.5%. There was no statistical difference about infectious causes between male and female. Conclusion: PSS seems to appear mostly in the middle age. In Vietnam, CMV was the most popular causes of patients with PSS, the second most common causes of this disease was HSV1.
Utility of 99mTc-MAA SPECT/CT for treatment plan of radioembolization using resin microspheres in HCC patients compared with 90Y PET/CT
Authors: Son Mai Hong , Kien Nguyen Do , Dung Nguyen Thi Kim , Chi Pham Minh , An Nguyen Binh , Ha Le Ngoc
Published: June 2022

Objective: The purpose of our study is to validate the utility of 90Y PET/CT compared to SPECT/CT simulation in dosimetry and prediction of treatment response. Subject and method: Thirty-four consecutive hepatocellular carcinoma (HCC) patients, intermediate and advanced stage who underwent 90Y resin microsphere transarterial embolization (TARE) were recruited in the study. Lung shunt fraction (LSF), tumor to-normal liver uptake ratio (TNr) and absorbed dose for target tumors were estimated on 99m Tc-MAA SPECT/CT and 90Y PET/CT. The patients were followed up after treatment within 3 months (2.8 ± 0.84 months) on contrast-enhanced CT to assess treatment response using mRECIST criteria. Result: The imaging characteristics including heterogeneity, necrosis and thrombosis uptake were better delineated on PET/CT imaging than SPECT/CT. The agreement and correlation of TNr on PET/CT and SPECT/CT were stronger. Dose delivery to tumor (Dtumor) threshold of 125Gy estimated on 99mTc-MAA SPECT/CT was more accurate than PET/CT for prediction of treatment response after 90Y-radioembolization in HCC patients with sensitivity of 87.5% and specificity of 90%. Conclusion: 99mTc-MAA SPECT/CT is superior to PET/CT to predict treatment response after 90Y resin microsphere treatment.
Mối liên quan giữa đột biến gen EGFR với nguy cơ di căn não ở bệnh nhân ung thư phổi không tế bào nhỏ: Kết quả từ nghiên cứu tiến cứu
Authors: Luận Phạm Văn , Tiến Nguyễn Đình , Hải Nguyễn Minh
Published: June 2022

Mục tiêu: Đánh giá mối liên quan giữa đột biến gen EGFR với nguy cơ di căn não ở bệnh nhân ung thư phổi không tế bào nhỏ (UTPKTBN). Đối tượng và phương pháp: Nghiên cứu tiến cứu, theo dõi dọc 213 bệnh nhân UTPKTBN giai đoạn I - IIIB được xét nghiệm đột biến gen EGFR từ năm 2014 đến 2020. Yếu tố nguy cơ được phân tích đa biến bằng phương trình hồi quy tuyến tính. Kết quả: Có 41,3% bệnh nhân xuất hiện di căn xa, trong đó di căn não 22,7%. Tỉ lệ đột biến gen EGFR dương tính là 27,2%, có 37,5% bệnh nhân di căn não mang đột biến gen EGFR, OR 2,89 (khoảng tin cậy 95%: 1,011 - 8,270), p=0,048. Bệnh nhân mang đột biến điểm L858R ở exon 21 có tỉ lệ di căn não 55,6% xu hướng cao hơn bệnh nhân mang đột biến xóa đoạn ở exon 19 (28,6%), nhưng sự khác biệt không có ý nghĩa thống kê (p>0,05). Không thấy yếu tố khác liên quan đến nguy cơ di căn não. Kết luận: Đột biến gen EGFR là một yếu tố làm tăng nguy cơ di căn não ở bệnh nhân ung thư phổi không tế bào nhỏ.
Khảo sát tần xuất mắc và một số đặc điểm lâm sàng, cận lâm sàng trẻ sơ sinh non tháng tăng đường huyết tại Bệnh viện Nhi Trung ương
Authors: Mai Phạm Thị , Minh Lê Trương Tuyết
Published: June 2022

Mục tiêu: Nghiên cứu tần xuất mắc và một số đặc điểm lâm sàng, cận lâm sàng trẻ sơ sinh non tháng tăng đường huyết tại Bệnh viện Nhi Trung ương. Đối tượng và phương pháp: 208 trẻ đẻ non tháng (≤ 32 tuần) điều trị tại Khoa Hồi sức sơ sinh, Bệnh viện Nhi Trung ương từ tháng 10/2019 đến tháng 7/2020. Kết quả: Tỷ lệ tăng glucose máu ở trẻ sơ sinh non tháng là 62,5%, đặc biệt 81,2% ở trẻ đẻ non dưới 28 tuần và 88,5% ở trẻ non tháng có cân nặng lúc sinh ≤ 1000g có tăng đường huyết. Trẻ sơ sinh non tháng tăng đường huyết có tần số tim, tỷ lệ hạ huyết áp và nồng độ CRP cao hơn có ý nghĩa thống kê so với nhóm trẻ sơ sinh có đường huyết bình thường. Kết luận: Tăng glucose máu thường gặp ở trẻ sơ sinh non tháng đặc biệt là nhóm trẻ sinh non dưới 28 tuần tuổi và cân nặng lúc sinh cực thấp.
Tiêu chí lựa chọn bệnh nhân trong phẫu thuật thay van động mạch chủ ít xâm lấn qua đường mở ngực trước phải dựa trên hình ảnh chụp cắt lớp vi tính
Authors: Đông Nguyễn Tiến , Hải Ngô Vi , Hùng Nguyễn Đăng , Minh Nguyễn Thái , Huy Đặng Quang , Ngọc Nguyễn Minh , Hiền Nguyễn Sinh
Published: June 2022

Mục tiêu: Đáng giá các tiêu chí lựa chọn bệnh trong phẫu thuật thay van động mạch chủ ít xâm lấn qua đường mở ngực trước phải dựa trên hình ảnh chụp cắt lớp vi tính (CT). Đối tượng và phương pháp: Thu thập hình ảnh CT động mạch chủ (ĐMC) của 14 bệnh nhân được phẫu thuật thay van ĐMC qua đường mở ngực trước phải tại Bệnh viện Tim Hà Nội từ tháng 10 năm 2019 đến tháng 6 năm 2020. Phân tích một số đặc điểm hình ảnh liên quan tới kỹ thuật mổ và 3 tiêu chí của nhóm tác giả Glauber M và cộng sự. Kết quả: Tỷ lệ ĐMC lệch phải là 2/14 (14,3%), khoảng cách từ ĐMC đến xương ức không quá 10 cm đạt 4/14 (28,6%), độ nghiêng của ĐMC lên lớn hơn 45­­0 chiếm 7/14 (50%); không có bệnh nhân nào đạt được cả 3 tiêu chí này. Đa phần (12/14 - 85,7%) van ĐMC được nhìn trực diện (vuông góc) từ khoang gian sườn II, và 100% vị trí kẹp ĐMC thông thường nằm ngang mức khoang gian sườn II và III. Kết luận: Tiêu chí lựa chọn bệnh nhân dựa trên hình ảnh chụp CT của Glauber M và cộng sự trong AVR-RAT có tính ứng dụng trong thực hành điều trị không cao, chỉ mang tính chất tham khảo. Đường mổ qua khoang gian sườn II, có thể mở rộng xuống khoang gian sườn III, là hợp lý ở hầu hết các trường hợp AVR-RAT.
Đánh giá hiệu quả huy động tế bào gốc tạo máu ra máu ngoại vi ở bệnh nhân xơ gan mất bù do vi rút viêm gan B
Authors: Sỹ Bùi Tiến , Hà Trần Thái , Hoàn Phan Quốc , Thịnh Nguyễn Tiến
Published: June 2022

Mục tiêu: Thực hiện quy trình và đánh giá hiệu quả huy động tế bào gốc tạo máu ra máu ngoại vi sau huy động G-CSF. Đối tượng và phương pháp: 31 bệnh nhân xơ gan mất bù do virus viêm gan B (tuổi từ 35 - 78 tuổi) được đưa vào nghiên cứu từ tháng 6 năm 2016 đến tháng 8 năm 2019. Các bệnh nhân được huy động bằng neupogen liều 60MIU/ngày tiêm dưới da 2 mũi sáng chiều trong 3 - 5 ngày liên tục. Sau 3 ngày xét nghiệm đếm tế bào gốc CD34+ máu ngoại vi, tiến hành thu nhận tế bào CD34+ từ máu ngoại vi bằng hệ thống Optia Spectra khi số lượng tế bào CD34 đạt ít nhất 10 tế bào/µl. Đánh giá chất lượng khối tế bào gốc tạo ra thông qua số lượng, tỷ lệ sống chết của tế bào CD34+. Kết quả: Thời gian trung bình huy động CD34+ là 4,35 ngày, trong đó dài nhất là 6 ngày (2 bệnh nhân) và ngắn nhất là 3 ngày (5 bệnh nhân). Số lượng tế bào CD34+ máu ngoại vi sau huy động là 22,03 tế bào/µl, trong đó giá nhỏ nhất là 10,16  và lớn nhất là 76,5 tế bào/µl. Giá trị cutoff 15 tế bào/µl sau 4 ngày huy động được xem là giá trị dự báo thành công cho liều CD34+ thu thập được. Liều tế bào CD34+ trung bình truyền cho bệnh nhân qua đường can thiệp động mạch gan là 1,59x106 tế bào/kg. Kết luận: 4 ngày liên tục huy động bằng neupogen liều 60MIU/ngày tiêm dưới da sáng chiều đối với bệnh nhân xơ gan mất bù đủ điều kiện để thực hiện thu nhận tế bào gốc tạo máu từ máu ngoại vi và đạt liều tế bào gốc CD34+/kg để điều trị cho bệnh nhân.
Nghiên cứu bào chế dung môi tách ARN từ nước tiểu, ứng dụng trong chẩn đoán một số tác nhân vi sinh vật gây bệnh
Authors: Giang Đào Phương , Trung Ngô Tất , Hiền Trần Thị Thu , Tĩnh Nguyễn Thị , Hoàn Phan Quốc
Published: June 2022

Mục tiêu: Bào chế thành công dung môi tách RNA tổng số từ bệnh phẩm nước tiểu. Đối tượng và phương pháp: Sử dụng các hoá chất hiện có dễ mua trong nước, pha chế thành dung môi tách chiết RNA tổng số từ các mẫu bệnh phẩm nước tiểu. Định lượng bằng kỹ thuật Real Time PCR theo nguyên lý Taqman Probe để đánh giá hiệu quả tách RNA bằng dung môi tự tạo. Kết quả: Pha chế thành công dung môi tách RNA tổng số từ nước tiểu có hiệu quả tách chiết tương đương với dung môi nhập ngoại. Kết luận: Dung môi tách ARN tổng số từ nước tiểu đã được tổng hợp thành công cho phép dùng trong các ứng dụng chẩn đoán một số tác nhân vi sinh vật gây bệnh.
Đánh giá tốc độ phân hủy sinh học và tính tương thích sinh học của vật liệu kết xương magie phủ hydroxyapatite trên mô hình invitro
Authors: Hanh Lê , Hải Lê Văn , Hoàng Nguyễn Thế , Hải Lê Minh , Trang Lê Thị , Quân Lê Văn , Nam Nguyễn Việt
Published: June 2022

Mục tiêu: Đánh giá tốc độ tự tiêu và khả năng tương thích sinh học của vật liệu kết xương magie (Mg) phủ hydroxyapatite (HAp) nhằm ứng dụng trong chấn thương chỉnh hình. Đối tượng và phương pháp: Vật liệu kết xương Mg phủ HAp được sử dụng cho thí nghiệm nuôi cấy tế bào trong môi trường MEM-a. Tốc độ tự tiêu của vật liệu kết xương được đánh giá bằng lượng khí hydro giải phóng và hình thái bề mặt mẫu. Khả năng tương thích sinh học của vật liệu kết xương được đánh giá qua hình thái tế bào, khả năng tăng sinh của tế bào. Kết quả: Thí nghiệm nuôi cấy tế bào MC3T3-E1 trong môi trường MEM-a cho thấy mẫu được phủ HAp không những thể hiện lượng khí hydro thoát ra giảm mà còn có mật độ tế bào tăng sinh lớn hơn nhiều so với mẫu không được phủ HAp. Kết luận: Lớp phủ HAp vừa có khả năng làm giảm tốc độ tự tiêu vừa làm tăng tính tương thích sinh học của vật liệu kết xương phù hợp để ứng dụng vào chấn thương chỉnh hình.
Ứng dụng cộng hưởng từ tưới máu trong trong bệnh lý nhồi máu não cấp tính: Báo cáo một trường hợp
Authors: Sơn Lê Hải , Thạch Nguyễn Văn , Ấn Nguyễn Ngọc , Quyết Lê Văn , Tuyến Nguyễn Văn , Vượng Nguyễn Văn , Tuyền Trương Thanh , Khánh Nguyễn Đình , Anh Hà Thế
Published: June 2022

Giá trị của cộng hưởng từ tưới máu trong bệnh lý nhồi máu não cấp, minh họa bằng một trường hợp đột quỵ nhồi máu cấp tính được chụp cộng hưởng từ tưới máu ở Khoa Chẩn đoán hình ảnh - Bệnh viện Trung ương Quân đội 108. Chúng tôi báo cáo một trường hợp nhồi máu cấp tính về đặc điểm lâm sàng, cận lâm sàng, đặc điểm tổn thương trên cộng hưởng từ tưới máu não và kết quả điều trị. Cộng hưởng từ tưới máu có ý nghĩa quan trọng chẩn đoán và điều trị nhồi máu não cấp tính, nhờ việc đánh giá được vùng còn khả năng hồi phục của mô não tổn thương, giúp ích cho việc điều trị và tiên lượng bệnh nhân.
Nhu cầu chăm sóc phục hồi chức năng và một số yếu tố liên quan đến mức độ độc lập trong sinh hoạt hàng ngày người bệnh đột quỵ não khi xuất viện tại Bệnh viện Chợ Rẫy năm 2020
Authors: Nghĩa Võ Hoàng , Châu Cao Minh , Quang Lã Ngọc
Published: June 2022

Mục tiêu: Xác định nhu cầu chăm sóc, phục hồi chức năng của người bệnh đột quỵ não khi xuất viện. Đánh giá mức độ độc lập trong sinh hoạt hàng ngày của người bệnh đột quỵ não khi xuất viện. Xác định một số yếu tố liên quan đến mức độ độc lập trong sinh hoạt hàng ngày của người bệnh đột quỵ não khi xuất viện tại Bệnh viện Chợ Rẫy. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang. Đối tượng bao gồm 215 người bệnh đột quỵ não được điều trị ổn định và cho xuất viện tại Bệnh viện Chợ Rẫy, người bệnh có đủ các tiêu chuẩn lựa chọn và tiêu chuẩn loại trừ rõ ràng. Đối tượng đồng ý tham gia nghiên cứu, được thăm khám, phỏng vấn trực tiếp bằng bộ câu hỏi thiết kế sẵn, cỡ mẫu thuận tiện. Thang điểm đánh giá các chức năng sinh hoạt hàng ngày theo Barthel. Kết quả và kết luận: Có 91,2% người bệnh có nhu cầu chăm sóc chung, nhu cầu chăm sóc cơ xương khớp nhiều nhất chiếm 91,2% và ít nhất là chăm sóc tiêu hoá đại tiện là 21,9%, tư thế đúng là 58,2%, hô hấp là 55,6%, chăm sóc loét phòng chống loét là 46,7%, tiết niệu là 42,2%, nuôi dưỡng là 38%. Chúng tôi thấy có 87,5% người bệnh có nhu cầu phục hồi chức năng, trong đó nhóm nhu cầu sinh hoạt hàng ngày cao nhất là 76,5%. Sau xuất viện nguyện vọng được hướng dẫn tập tại nhà chiếm 87,5%, mong muốn được phục hồi chức năng cộng đồng là 56,6%, muốn có dịch vụ tập tại nhà 25,2%, và 18,8% muốn được cung cấp thông tin cơ sở phục hồi chức năng tại địa phương. Trong sinh hoạt hàng ngày tỷ lệ phụ thuộc tương đối cao chiếm 66,9%, trong đó phụ thuộc hoàn toàn là 28,8%. Các yếu tố liên quan đến mức độ độc lập trong sinh hoạt hàng ngày của người bệnh bao gồm tuổi (p<0,05), giới tính (p<0,05), tình trạng được phục hồi chức năng (p<0,05), bên liệt, tình trạng liệt (p<0,05), co rút cứng khớp (p<0,05), loại đột quỵ.
Knowledge and Risk factors of Cervical cancer among women in towns of Pune Division - Maharashtra
Authors: Gharpankar Pradnya , Mariyappan Akhila , Oak Payal , Kumbhar Pradnya , Gupta Sakshi , Yewale Janvi
Published: June 2022

Cervical cancer (CC) is a worldwide disease with 97000 of new cases per year occurring in most populated country, India. The objective of this study was to find possible factors which could affect knowledge about CC and, some CC risk factors in our community. A community-based cross-sectional study was carried out in Maharashtra, State of India. Knowledge about CC is modulated by the level of education and the young age of women. Risk factors although universal seem to vary according to the geographical area and the socio-cultural environment where one lives. Some risk factors identified are early onset of sexual intercourse, polygamous marriages, multiple sexual partners, the sexual behavior of the male partner, Human papilloma virus (HPV) infections, sexually transmitted diseases (STDs), Human Deficiency Virus (HIV), and history of genital warts. No enhancement of lifestyle as the voluntary refusal of cervical cancer screening and CC vaccination have also be found to be risky attitudes for CC.
Qsar and Docking Studies of Some Novel Piperine Analogues as Monoamine Oxidase Inhibitors
Authors: Bhardwaj Sakshi , Dubey Sonal
Published: June 2022

Piperine is an attractive target from natural sources for designing of novel compounds for many pharmacological activities. In present work, series of MAO inhibitors were taken and QSAR models were generated using MLRA. The best model were validated using test set, they exhibited r2 0.8427 and q2 0.7852 for MOA-B inhibitors; MAO-A inhibitors showed r2 0.7970 and q2 0.6657. Models. The QSAR models were used to design 70 new piperine analogue and docking studies were performed to check their inhibitory activity. Docking studies were performed using AutoDock, with proteins 2BXR and 2VZ2 for MAO-A and MAO-B inhibitory activity respectively. P12 and P11 for 2BXR showed best binding energy of -5.89 kcal/mol. and -6.43 kcal/mol respectively whereas P1078 and P1090 showed binding energy of -5.86 kcal/mol. and -8.56 kcal/mol for 2VZ2 respectively.
A Short Review on Hendra Virus
Authors: S. Girase Dhiraj , G. Bagul Dnyaneshwar , S. Bhawsar Ritik , Z. Shaikh Azam , S. Jain Ritik.
Published: June 2022

In our daily life we are exposed to different viruses and sometimes they also infect the human body. At times, they even cause life-threatening illnesses, which can put our lives in jeopardy. Also, some viruses exist which can enter the human body from animals are known as 'zoonotic viruses'. Hendra virus is also a zoonotic virus which comes under genus of 'henipavirus' and family 'paramyxoviridae'. This virus is identified during 1994-2010 outbreak of hendra virus in horses and humens at suburb of brisbane, Australia, that time out of 21, 14 horses and one humen is dead due to respiratory disease. This virus shares its genus with nipah virus. The major reservoir of this virus was found in flying foxes (Bats from the genus pteropus). This review article mainly emphasize on the structure, epidemiology, pathogenesis, diagnosis, treatment, sign and symptoms of hendra virus.
A Brief Review on Resveratrol
Authors: Malviya Vedanshu , Tawar Mukund , Burange Prashant , Jodh Rahul
Published: June 2022

Resveratrol can be recognized as a best nutraceutical. Resveratrol is a novel nutraceutical in which not many details are known therefore an attempt was made to review the details which may be used for the further research. Resveratrol is known to be a polyphenol named as stilbenoid group which is a phytoalexin secreted by more than 70 plant species which is having many pharmacological activities like anticancer, anti-inflammatory, anti-ageing, neuroprotective, cardioprotective, anti-microbial and etc. This natural table top food has a lower bioavailability with lower aqueous solubility. From this review we can conclude that resveratrol is a unique complex having various properties with lots of other benefits.
A Review on Emulgels as a Novel Approach for Topical Drug Delivery
Authors: Veni N. Krishna , P. Yashwanthi , B. Hemalatha , K. Padmalatha
Published: June 2022

Topical drug delivery has been used for centuries for the treatment of local skin disorders. Drugs applied to the skin for their local action include antiseptics, antifungal agents, skin emollients, and protectants. Major disadvantage of gel is the delivery of hydrophobic drug. This can be overcome by emulgels. Emulgels have emerged as one of the most attractive topical delivery system as it has dual release control system i.e. gel and emulsion. Since hydrophobic drugs are not soluble in gel bases, it causes problem during the release of drug. When gel and emulsion are used in combination the dosage form is referred as emulgel. In emulgel formulation, the hydrophobic drugs could be incorporated into the oil phase and then oily globules are dispersed in aqueous phase resulting in o/w emulsion which can be mixed into the gel base. The major aim behind this formulation is delivery of hydrophobic drugs to systemic circulation via skin. A distinctive feature of topical drug delivery is the straight accessibility of the skin as a target organ for the treatment. This might be proving improved stability and release of drug than just incorporating drugs into gel base. The purpose of this review article is to exemplify emulgel for topical drug delivery, advantages and disadvantages of emulgel, physiology of skin, major components of emulgel, method of preparation, characterization and marketed products of emulgel.