bluuebunny/crossref_metadata_2025 huggingface dataset:
Ρόλος της PTHrP και του υποδοχέα PTH/PTHrP στην παθοφυσιολογία των καρκινικών κυττάρων του προστάτη
Authors: Τέντα Ρωξάνη
Published: August 2021

H PTHrP ανακαλύφθηκε κατά τη διάρκεια έρευνας για την αίτια που προκαλεί το σύνδρομο υπερασβεστιαιμιας απο νεόπλασμα Η PTHrP όμως παράγεται τόσο απο κακοήθεις όγκους οσο και απο πολλούς φυσιολογικούς ιστούς κατά την εμβρυϊκή και ενήλικη ζωη σε μικρότερες όμως ποσότητες Η βιολογική της δράση φαίνεται οτι εξασφαλίζεται απο τον υποδοχέα ΡΤΗ/ΡΤΗΓΡ που είναι κοινός και για την παραθορμονη (PTH) Η ανάπτυξη οστικών μεταστάσεων απο τα καρκινικά κύτταρα του προστάτη αποδίδεται στην ευνοϊκή συμπεριφορά του μικροπεριβαλλοντος των οστών που συνίσταται στην παράγωγη παραγόντων όπως του ινσουλινο μιμητικού αυξητικού παράγοντα 1 (IGF 1) του μετατρεπτικου αυξητικού παράγοντα βήτα 1 (TGFßl) της ιντερλευκινης 6 (IL 6) και του ινοβλαστικου αυξητικού παράγοντα (bFGF) οι οποίοι αναστέλλουν την προκαλούμενη απο χημειοθεραπεία η ανδρογονικο αποκλεισμό απόπτωση των προστατικών καρκινικών κυττάρων Ο στόχος ήταν να αναλύσουμε το ρολό της PTHrP και του υποδοχέα PTH/PTHrP σε επίπεδο mRNA και πρωτεΐνης σε καρκινικά κύτταρα προστάτη (PC-3) άλλα και σε κυταρα οστεοβλαστικου φαινοτύπου (MG-63) πριν και μετά τη διέγερση τους με αυξητικούς παράγοντες Τα αποτελέσματα μας δείχνουν οτι α) τα καρκινικά κύτταρα προστάτη (PC-3) άλλα και οι οστεοβλαστες (MG 63) εκφράζουν PTHrP και τον υποδοχέα PTH/PTHrP β) οι αυξητικοί παράγοντες IGF-1 TGFßl IL 6 και bFGF επάγουν την έκφραση της PTHrP γ) οι αυξητικοί παράγοντες δεν επηρεάζουν την έκφραση του υποδοχέα PTH/PTHrP και δ) αυτοί οι αυξητικοί παράγοντες ενισχύουν την περιπυρηνικη εντόπιση της PTHrP τόσο στα κύτταρα PC-3 οσο και στα MG 63 Επομένως μέρος της αντιαποπτωτικης δράσης των αυξητικών παραγόντων του οστικού μικροπεριβαλλοντος ενδέχεται να διαμεσολαβειται απο την PTHr
Η μετατροπή των αρχαίων ελληνικών ναών και ιερών σε εκκλησίες στον ελλαδικό χώρο κατά την παλαιοχριστιανική περίοδο
Authors: Ηλιόπουλος Δημήτριος
Published: August 2021

ΣΤΗ ΔΙΑΤΡΙΒΗ ΕΞΕΤΑΖΕΤΑΙ ΤΟ ΦΑΙΝΟΜΕΝΟ ΤΗΣ ΜΕΤΑΤΡΟΠΗΣ ΤΩΝ ΑΡΧΑΙΩΝ ΕΛΛΗΝΙΚΩΝ ΝΑΩΝ, ΙΕΡΩΝ ΚΑΙ ΗΡΩΩΝ ΣΕ ΕΚΚΛΗΣΙΕΣ ΚΑΤΑ ΤΗΝ ΠΡΩΤΟΒΥΖΑΝΤΙΝΗ ΠΕΡΙΟΔΟ (4ΟΣ-6ΟΣ ΑΙΩΝΕΣ) ΣΤΟΝ ΕΛΛΑΔΙΚΟ ΧΩΡΟ. ΣΗΜΕΙΩΝΟΝΤΑΙ ΤΑ ΜΕΘΟΔΟΛΟΓΙΚΑ ΠΡΟΒΛΗΜΑΤΑ ΠΟΥ ΑΠΟΡΡΕΟΥΝ ΑΠΟ ΤΗΝ ΕΛΛΕΙΨΗ ΣΧΕΤΙΚΩΝ ΓΡΑΠΤΩΝ ΠΗΓΩΝ ΚΑΙ ΤΙΣ ΣΥΝΗΘΩΣ ΠΕΡΙΛΗΠΤΙΚΕΣ ΑΝΑΣΚΑΦΙΚΕΣ ΕΚΘΕΣΕΙΣ. ΕΞΕΤΑΖΕΤΑΙ ΤΟ ΙΣΤΟΡΙΚΟ ΠΛΑΙΣΙΟ ΚΑΙ Η ΠΟΙΚΙΛΟΜΟΡΦΙΑ ΤΟΥ ΦΑΙΝΟΜΕΝΟΥ ΚΑΤΑ ΠΕΡΙΟΧΕΣ ΤΗΣ ΑΥΤΟΚΡΑΤΟΡΙΑΣ. Η ΚΑΤΑΡΤΙΣΗ ΕΝΟΣ ΑΝΑΛΥΤΙΚΟΥ ΚΑΤΑΛΟΓΟΥ ΤΩΝ ΕΙΔΩΛΟΛΑΤΡΙΚΩΝ ΛΑΤΡΕΥΤΙΚΩΝ ΚΤΗΡΙΩΝ ΠΟΥ ΜΕΤΑΤΡΑΠΗΚΑΝ ΣΕ ΧΡΙΣΤΙΑΝΙΚΕΣ ΕΚΚΛΗΣΙΕΣ ΟΔΗΓΕΙ ΣΤΗΝ ΕΞΑΓΩΓΗ ΣΥΜΠΕΡΑΣΜΑΤΩΝ ΣΧΕΤΙΚΑ ΜΕ ΤΟΥΣ ΠΑΡΑΓΟΝΤΕΣ ΠΟΥ ΟΔΗΓΗΣΑΝ ΣΤΗΝ ΕΠΙΛΟΓΗ ΑΥΤΗ, ΤΗ ΓΕΩΓΡΑΦΙΚΗ ΚΑΤΑΝΟΜΗ ΚΑΙ ΤΗ ΣΥΧΝΟΤΗΤΑ ΤΟΥ ΦΑΙΝΟΜΕΝΟΥ, ΤΑ ΑΙΤΙΑ ΚΑΤΑΣΤΡΟΦΗΣ ΤΩΝ ΑΡΧΑΙΩΝ ΛΑΤΡΕΥΤΙΚΩΝ ΧΩΡΩΝ ΚΑΙ ΤΗΝ ΕΠΙΒΙΩΣΗ ΤΗΣ ΕΙΔΩΛΟΛΑΤΡΙΑΣ ΣΤΟΥΣ ΠΡΩΙΜΟΥΣ ΒΥΖΑΝΤΙΝΟΥΣ ΧΡΟΝΟΥΣ. ΕΠΙΣΗΣ, ΔΙΕΡΕΥΝΑΤΑΙ Ο ΧΡΟΝΟΣ ΚΑΤΑΣΤΡΟΦΗΣ ΤΩΝ ΕΘΝΙΚΩΝ ΙΕΡΩΝ ΚΑΙ ΤΗΣ ΙΔΡΥΣΗΣ ΤΩΝ ΧΡΙΣΤΙΑΝΙΚΩΝ ΕΚΚΛΗΣΙΩΝ, ΚΑΙ ΕΡΜΗΝΕΥΕΤΑΙ ΙΣΤΟΡΙΚΑ ΤΟ ΔΙΑΣΤΗΜΑ ΤΟ ΟΠΟΙΟ ΜΕΣΟΛΑΒΗΣΕ ΜΕΤΑΞΥ ΤΩΝ ΔΥΟ ΑΥΤΩΝ ΦΑΣΕΩΝ. Η ΠΛΕΙΟΨΗΦΙΑ ΤΩΝ ΕΙΔΩΛΟΛΑΤΡΙΚΩΝ ΝΑΩΝ ΠΟΥ ΜΕΤΑΤΡΑΠΗΚΑΝ ΣΕ ΕΚΚΛΗΣΙΕΣ ΧΡΟΝΟΛΟΓΕΙΤΑΙ ΣΤΟΝ 5Ο ΚΑΙ 6Ο ΑΙΩΝΑ. ΤΟ ΦΑΙΝΟΜΕΝΟ ΤΗΣ ΒΙΑΙΗΣ ΚΑΤΑΣΤΡΟΦΗΣ ΕΙΔΩΛΟΛΑΤΡΙΚΩΝ ΝΑΩΝ ΕΞΕΤΑΖΕΤΑΙ ΛΑΜΒΑΝΟΝΤΑΣ ΥΠΟΨΗ ΤΑ ΑΣΑΦΗ ΑΡΧΑΙΟΛΟΓΙΚΑ ΔΕΔΟΜΕΝΑ ΚΑΙ ΤΗΝ ΙΔΙΑΙΤΕΡΟΤΗΤΑ ΤΟΥ ΕΛΛΑΔΙΚΟΥ ΧΩΡΟΥ ΕΝΤΟΣ ΤΗΣ ΑΥΤΟΚΡΑΤΟΡΙΑΣ ΤΟΣΟ ΛΟΓΩ ΤΟΥ ΣΘΕΝΑΡΟΥ ΕΙΔΩΛΟΛΑΤΡΙΚΟΥ ΣΤΟΙΧΕΙΟΥ ΟΣΟ ΚΑΙ ΛΟΓΩ ΤΗΣ ΕΛΛΕΙΨΗΣ ΑΓΙΟΛΟΓΙΚΩΝ ΠΗΓΩΝ. ΔΙΕΡΕΥΝΩΝΤΑΙ ΟΙ ΑΡΧΙΤΕΚΤΟΝΙΚΕΣ ΤΡΟΠΟΠΟΙΗΣΕΙΣ ΤΩΝ ΕΙΔΩΛΟΛΑΤΡΙΚΩΝ ΛΑΤΡΕΥΤΙΚΩΝ ΚΤΙΣΜΑΤΩΝ ΠΡΟΚΕΙΜΕΝΟΥ ΝΑ ΕΞΥΠΗΡΕΤΗΣΟΥΝ ΤΙΣ ΑΝΑΓΚΕΣ ΤΗΣ ΧΡΙΣΤΙΑΝΙΚΗΣ ΛΑΤΡΕΙΑΣ, ΚΑΘΩΣ ΚΑΙ ΤΟΠΟΓΡΑΦΙΚΑ ΘΕΜΑΤΑ, ΟΠΩΣ Η ΘΕΣΗ ΤΩΝ ΕΚΚΛΗΣΙΩΝ ΣΕ ΣΧΕΣΗ ΠΡΟΣ ΤΟΝ ΠΡΟΫΠΑΡΧΟΝΤΑ ΕΙΔΩΛΟΛΑΤΡΙΚΟ ΝΑΟ, ΕΝΤΟΣ ΤΩΝ ΑΣΤΙΚΩΝ ΚΕΝΤΡΩΝ Η ΣΤΗΝ ΥΠΑΙΘΡΟ, ΚΑΘΩΣ ΚΑΙ Η ΙΔΡΥΣΗ ΟΙΚΙΣΜΩΝ ΣΤΑ ΠΡΩΗΝ ΕΘΝΙΚΑ ΙΕΡΑ. ΕΠΙΣΗΣ ΕΞΕΤΑΖΟΝΤΑΙ ΟΙ ΘΕΩΡΙΕΣ ΟΙ ΟΠΟΙΕΣ ΕΡΜΗΝΕΥΟΥΝ ΤΗ ΣΥΝΕΧΙΣΗ ΤΗΣ ΕΙΔΩΛΟΛΑΤΡΙΚΗΣ ΛΑΤΡΕΙΑΣ ΣΤΑ ΑΡΧΑΙΑ ΙΕΡΑ ΜΕ ΝΕΟ, ΧΡΙΣΤΙΑΝΙΚΟ, ΠΕΡΙΕΧΟΜΕΝΟ ΙΔΙΑΙΤΕΡΑ ΜΕ ΑΝΑΦΟΡΑ ΣΤΟΝ ΕΛΛΑΔΙΚΟ ΧΩΡΟ. ΣΥΜΠΛΗΡΩΜΑΤΙΚΑ, ΜΕΛΕΤΑΤΑΙ ΜΙΑ ΣΕΙΡΑ ΕΙΔΙΚΩΝ ΘΕΜΑΤΩΝ, ΟΠΩΣ Η ΣΤΑΣΗ ΤΩΝ ΧΡΙΣΤΙΑΝΩΝ ΕΝΑΝΤΙ ΤΩΝ ΑΡΧΑΙΩΝ ΛΑΤΡΕΥΤΙΚΩΝ ΑΓΑΛΜΑΤΩΝ ΚΑΙ Η ΤΥΧΗ ΤΩΝ ΙΕΡΩΝ ΤΟΥ ΑΣΚΛΗΠΙΟΥ ΚΑΙ ΤΩΝ ΠΑΝΕΛΛΗΝΙΩΝ ΙΕΡΩΝ ΚΑΤΑ ΤΗΝ ΠΡΩΤΟΒΥΖΑΝΤΙΝΗ ΕΠΟΧΗ
Επίδραση ισοπρενοειδών λιπιδίων και χλωρόφυλλων στην οξειδωτική σταθερότητα ελαίων πλούσιων σε μονοακόρεστα λιπαρά οξέα
Authors: Ψωμιάδου Ελένη
Published: August 2021

Σκοποί της- διατριβής- ήταν η- μελέτη TOC- δράσης του- σκουαλενιου,- της- CL τοκοφερόλης^ τωνκαροτενοειδων κοα των χλωροφυλλων στη σταθερότητα λιπαρών υλών πλουσίων σε μονοακορεσταλιπαρα-οξεο-ίΜΑΟί Τα παρθένο ελαιόλαδα (H &νχρησιμοποιηθηκε-ως-(ρΐ)σικα μοντέλα λιπαρής ύληςπλούσιας σε ΜΛΟ που περιείχε ολα τα παραπάνω συστατικά και οι τριακυλογλυκερολες ελαιολάδουμετά- απα απομάκρυνση- πρα/ανηοξειδωτικων- ενο)σεων ως-τα αντίστοιχα μοντέλα προσομοίωσης Η δράση του σκουαλενιου στο μοντέλο εξετάσθηκε σε διαφορετικές συνθήκες αυτοξειδωσης καιφωτοοξειδωσης.- OL μεταβολές- στα υπόστρωμα- μελετήθηκαν- με- περιοδικούς- προσδιορισμούς των πρωτογενών προϊόντων της οξείδωσης, η σταθερότητα των ελαίων εκτιμήθηκε ιιε τη δοκιμή Rancimat καΐ-οι μεταβολές- (ποιοτικες-καιποσατικες)- των μελετωμενων σικιτατικων- με- υγροχρωματογραφικες και φασματοσκοπικές μεθόδους Το σκουαλενιο παρουσίασε αξιοσημείωτη σταθερότητα κατά την αυτοξειδωση καΐ-η- ασθενης-αντιοξεΐδυίτικη- δράση- του αποδόθηκε- στα φαινόμενα της_ανταγωνιστικης Ι οξείδωσης Σημαντικότερη ήταν η συμβολή του κατά τη φωτοευαισθητοποιημενη οξείδωση καθώς παρείχε-προστασία στην-α-τοκοχρερολ,η. Προκεηιενου-να-γΛνεΐ-δυνατη-η-παρα,κολουθηση-τω-V μεταβολών των μελετωμενων συστατικών αναπτυνθηκε μεθοδολογία υγρής χρωματογραφίας υψηλής απόδοσης που επέτρεψε-τοχι ταυτόχρονα προσδιορισμό τοκοφερολών., καροτενοειδων- κανχλωραφυλλων^ EL εξέταση ι ενός μεγάλου αριθμού δειγμάτων έδωσε στοΐγεια για τα επίπεδα της α τοκοφερόλης, καροτενοειδων καιγλωροφυλ>ων- σταΕλληνικο DJEL Απατον προσδιορισμαα-τοκοφερολης-και χρωστικών-προέκυψαν νεα στοινεια για τη συμβολή τους στη σταθερότητα επιλεγμένων δειγμάτων Π Ε. όπως η αντιοξειδωτικη δρα(Π^της-φαιοφυτινης-α-στα σκαταδΐ-Kaua προστατευτικος_ρολος της- α-τοκοφερολης-τασα κατά την αυτοξειδωση οσο και τη ρωτοοξειδωση.
Η χωρική συγκρότηση του μουσειακού νοήματος
Authors: Σταυρουλάκη Ιωάννα
Published: August 2021

Αντικείμενο της διατριβής είναι η χωρική συγκρότηση του μουσειακού νοήματος. Εστιάζει ειδικά στη θεμελιώδη μουσειακή πράξη; Την επαναπλαισίωση αντικειμένων αποκομμένων από τα παραδοσιακά τους περιβάλλοντα στο μουσειακό χώρο. Η διατριβή εξετάζει το πώς η αλλαγή του χωρικού πλαισίου συνδέεται με την αλλαγή του νοήματος και του ρόλου του αντικειμένου, όταν μετατρέπεται σε μουσειακό έκθεμα. Ειδικό αντικείμενο της έρευνας είναι η βυζαντινή εικόνα «Η Σοφία του Θεού» που εκτίθεται στο Μουσείο Βυζαντινού Πολιτισμού της Θεσσαλονίκης και αρχικά βρισκόταν στο τέμπλο του Βυζαντινού ναού Αγ. Σοφίας Θεσσαλονίκης (εκτός από την έρευνα της βιβλιογραφίας). Η διατριβή αναπτύσσει μια πρωτότυπη μέθοδο ανάλυσης του χώρου για να μελετήσει και να συγκρίνει συστηματικά τα δύο χωρικά πλαίσια – το ναό και το μουσείο. Παράλληλα αναδεικνύει τη ένταση μεταξύ του αρχιτεκτονικού κελύφους και του σχεδιασμού της έκθεσης στη διαπραγμάτευση του υλικού και νοηματικού περιεχομένου του μουσείου. Η μέθοδος ανάλυσης του χώρου εστιάζει στη χωρική εμπειρία και την αντιληπτική δομή που συγκροτεί το κάθε χωρικό πλαίσιο για τη θέαση των αντικειμένων.
Calcium imaging analysis – how far have we come?
Authors: Robbins Miranda , Christensen Charles N. , Kaminski Clemens F. , Zlatic Marta
Published: August 2021

Techniques for calcium imaging were first demonstrated in the mid-1970s, whilst tools to analyse these markers of cellular activity are still being developed and improved today. For image analysis, custom tools were developed within labs and until relatively recently, software packages were not widely available between researchers. We will discuss some of the most popular methods for calcium imaging analysis that are now widely available and describe why these protocols are so effective. We will also describe some of the newest innovations in the field that are likely to benefit researchers, particularly as calcium imaging is often an inherently low signal-to-noise method. Although calcium imaging analysis has seen recent advances, particularly following the rise of machine learning, we will end by highlighting the outstanding requirements and questions that hinder further progress and pose the question of how far we have come in the past sixty years and what can be expected for future development in the field.
Substantial impact of post-vaccination contacts on cumulative infections during viral epidemics
Authors: Rochman Nash , Wolf Yuri , V. Koonin Eugene
Published: August 2021

Background: The start of 2021 was marked by the initiation of a global vaccination campaign against the novel coronavirus SARS-CoV-2. Formulating an optimal distribution strategy under social and economic constraints is challenging. Optimal distribution is additionally constrained by the potential emergence of vaccine resistance. Analogous to chronic low-dose antibiotic exposure, recently inoculated individuals who are not yet immune play an outsized role in the emergence of resistance. Classical epidemiological modelling is well suited to explore how the behavior of the inoculated population impacts the total number of infections over the entirety of an epidemic.

Methods: A deterministic model of epidemic evolution is analyzed, with seven compartments defined by their relationship to the emergence of vaccine-resistant mutants and representing three susceptible populations, three infected populations, and one recovered population. This minimally computationally intensive design enables simulation of epidemics across a broad parameter space. The results are used to identify conditions minimizing the cumulative number of infections.

Results: When an escape variant is only modestly less infectious than the originating strain within a naïve population, the cumulative number of infections does not monotonically decrease with the rate of vaccine distribution. Analysis of the model also demonstrates that inoculated individuals play a major role in the mitigation or exacerbation of vaccine-resistant outbreaks. Modulating the rate of host–host contact for the inoculated population by less than an order of magnitude can alter the cumulative number of infections by more than 20%.

Conclusions: Mathematical modeling shows that limiting post-vaccination contacts can perceptibly affect the course of an epidemic. The consideration of limitations on post-vaccination contacts remains relevant for the entire duration of any vaccination campaign including the current status of SARS-CoV-2 vaccination.
Case Report: Penetrating Thoracic Trauma by A Gunshot Involving the Heart
Authors: Atreya Alok , Menezes Ritesh G. , Timalsina Ashal , Bashyal Geeta , Gyawali Lokaratna , Gyawali Sushila
Published: August 2021

Firearm-related mortality is not frequently encountered in a country like Nepal where there are stringent laws prohibiting the buying, selling, carrying or storing of firearms. To possess a firearm a person must have a valid license. Wounds produced by firearms have typical characteristics the knowledge of which helps to identify the type of firearm used, range of fire, the position of the victim, and whether the manner of death was homicidal, suicidal, or accidental. The present case is the first autopsy-based study from Nepal which discusses the wounds produced by firearms with an interpretation of such findings for medicolegal purposes. The present case highlights a social problem where the victim, a psychiatric patient, had no access to prescription medication due to coronavirus disease (COVID-19) related lockdown.
A quantitative analysis of sources of changes in government expenditures on health, 2000 to 2015: what can we learn from experience to date?
Authors: Saxenian Helen , Bharali Ipchita , Ogbuoji Osondu , Yamey Gavin
Published: August 2021

Background: Achieving universal health coverage (UHC) requires increased domestic financing of health by low-income countries (LICs) and middle-income countries (MICs). It is critical to understand how much governments have devoted to health from domestic sources and how much growth might be realistic over time.

Methods: Using data from WHO’s Global Health Expenditure Database, we examined how the composition of current health expenditure changed by financing source and the sources of growth in health expenditures from 2000-2015 across different income groups. We disaggregated how much growth in government expenditures on health from domestic sources was due to economic growth, growth in government spending as a share of GDP, and reallocations in government expenditures towards health.

Results: Lower MICs (LMICs) and upper MICs (UMICs), as a group, saw a significant reduction in out-of-pocket expenditures and a significant growth in government expenditures on health from domestic sources as a share of current health expenditures over the period. This trend indicates likely progress in the pathway to UHC. For LICs, these trends were more muted. Growth in government expenditure on health from domestic sources was driven primarily by economic growth in LICs, LMICs, and UMICs. Growth in government expenditure on health due to increased government spending as a share of GDP was high in UMICs. For the high-income country group, where economic growth was relatively slower and government spending was already high with strong tax bases, the largest driver of growth in government expenditure on health from domestic sources was reallocation of the government budget towards health.

Conclusions: Dialogue on domestic resource mobilization needs to emphasize overall economic growth and growth in the government spending as a share of GDP as well as the share of health in the government budget.
Long-term outcomes after hip fracture in Ireland: a protocol for a systematic review of traditional and grey literature
Authors: Walsh Mary E. , Cunningham Caitriona , Brent Louise , Savin Bibiana , Fitzgerald Michelle , Blake Catherine
Published: August 2021

Background: Hip fracture is experienced by almost 3,500 older people in Ireland annually. The Irish Hip Fracture Database (IHFD), which drives clinical improvements in acute hospitals, aims to allow recording of longer-term outcomes. Feasible and robust methods of data collection need to be identified to inform this activity. The aim of this systematic review is to identify, describe and appraise studies that have collected long-term outcomes after hip fracture in Ireland in the last 15 years and to generate pooled estimates of outcomes if appropriate.

Methods: A search of electronic databases (MEDLINE, Embase, Scopus, Web of Science and CINAHL) and grey literature sources will be conducted for journal articles, conference abstracts, academic theses, and reports. Search terms related to hip fracture and Ireland will be included for most sources. The search will be supplemented by email contact with relevant professionals.

Observational and interventional studies published between 2005 and 2021 will be included if outcome data were collected in the Republic of Ireland in patients with hip fracture. Outcomes of interest will include data collected after discharge from an inpatient setting or at a fixed time-point greater than 30 days after fracture, hospital admission or surgery. Information relating to study characteristics, description of researchers, data collection methods, patient characteristics and long-term outcomes will be extracted from each study and summarised in tables. Studies will be assessed for risk of bias by two review authors. Where outcomes are sufficiently homogeneous, meta-analyses of estimates will be conducted.

Conclusion: Results from this study will inform the planning of further qualitative research to explore barriers and facilitators of long-term outcome collection in Ireland. It will form the basis of education and training for future data collectors in this setting.
Opportunities for the Formation of Information and Digital Competencies of a HR Specialist Within the Framework of a Higher School
Authors: Ashurbekov R. , Kuz'minova T.
Published: August 2021

The article presents the results of the analysis of federal educational standards for personnel management at the undergraduate and graduate level, which showed that higher educational institutions can creatively approach the formation of information and digital competencies in students. It has been substantiated that the formation of digital competencies is based on information competencies and is associated with the ability to extract, process, store and transmit big data. For the formation of digital competencies among students studying in the field of "personnel management", it is proposed to introduce the study of the free software product KNIME distributed on the Internet in the work program of the discipline "Information technologies in personnel management", which allows working with big data at the level of large nodes without knowledge of programming languages. The article provides an example of a simple model created in KNIME to analyze the labor market of specialists required by an enterprise by extracting and processing data presented on the website hh.ru.
Fluid Models of Parallel Service Systems Under FCFS
Authors: Nov Yuval , Weiss Gideon , Zhang Hanqin
Published: August 2021

In parallel service systems, customers of various types are served simultaneously by several servers that have some dierent and some overlapping skills or capacities. Examples include customer routing in call centers, scheduling of hospital operating rooms, and driver assignment in ride-hailing services. First come first served (FCFS) is a natural and widespread resource allocation policy, yet its performance both during the transient stage and in the long run is often difficult to analyze. In particular, matching rates, which indicate what fraction from all services are of a specific server customer type, are difficult to evaluate under FCFS. In Fluid Models of Parallel Service Systems under FCFS, Yuval Nov, Gideon Weiss, and Hanqin Zhang formulate a stochastic queueing model for such systems and study its fluid approximation. The paper demonstrates the usefulness and the limitations of exploring fluid performance in evaluating system behavior in terms of stability, responsiveness, and utilization.
Pengaruh Penambahan Ikan Lele (Clarias gariepinus) terhadap Sifat Organoleptik Slondok
Authors: Purwanti Heni , Habibie Intan Jd
Published: August 2021

Slondok merupakan makanan ringan yang menggunakan bahan utama ubi kayu. Sebagai makanan ringan yang menyerupai kerupuk, slondok mempunyai sifat gurih, renyah dan ringan sebagai camilan. Rasa gurih pada slondok biasanya karena penambahan bumbu berupa garam, ketumbar, bawang putih dan penguat rasa buatan dari bahan kimia. Untuk mengurangi pemakaian bahan kimia, maka dibuat slondok dengan penambahan ikan lele. Ikan lele yang kaya protein diharapkan dapat menggantikan bahan kimia untuk menguatkan rasa gurih pada slondok selain juga dapat meningkatkan nilai gizi slondok. Penelitian eksperimen ini bertujuan untuk mengetahui penambahan ikan lele pada slondok yang disuka oleh konsumen. Hasil penelitian menunjukkan bahwa penambahan ikan lele sebesar 15% sampai 25% pada slondok mempunyai tingkat kesukaan disukai.
In vitro antibacterial activities of crude extracts of nine plants on multidrug resistance bacterial isolates of wound infections
Authors: Prastiyanto Muhammad Evy , DEWI NI MADE BUNGA ANGGELIA , PRATININGTIAS TUSY DIAH , PRATIWI NI MADE RAI , WINDAYANI ANGGIS , WAHYUNENGSIH EKA , ASTUTI ASTUTI , AMIR ELVIRA , WARDOYO FANDHI ADI
Published: August 2021

Abstract. Prastiyanto ME, Dewi NMBA, Pratiningtias TD, Pratiwi NMR, Windayani A, Wahyunengsih E, Astuti, Amir E, Wardoyo FA. 2021. In vitro antibacterial activities of crude extracts of nine plants on multidrug resistance bacterial isolates of wound infections. Biodiversitas 22: 2641-2647. Wound infections caused by bacteria is a become serious health problems, multidrug resistance bacteria (MDR) have increased this problem more severely, and therefore, antibacterial agents from natural biological sources are necessary to overcome these problems. This study examined the antibacterial activities of nine plants, i.e. garlic (Allium sativum), Solo garlic (Allium sativum), Java plum leaf (Syzygium cumini), Java plum fruit (Syzygium cumini), lime (Citrus aurantifolia), Kaffir lime (Citrus hystrix), Siamese weed (Chromolaena odorata), mangosteen (Garcinia mangostana) and bitter melon (Momordica charantia), against MDR bacteria isolated from wounds. The antibacterial activities were evaluated using agar well diffusion assay to determine the inhibition zones, and microdilution method to determine the value of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The best antibacterial activities were calculated as the most extensive inhibition zones with the smallest MIC and MBC values. Ethanol extracts from five plants (garlic, Solo garlic, Java plum (leaf), Kaffir lime and bitter melon) showed antibacterial activities against three MDR bacteria isolated from wounds. The bitter melon extract had the largest zones, 19.3 mm (methicillin-resistant Staphylococcus aureus [MRSA]), 10.6 mm (ESBL-producing Escherichia coli), and 13 mm (carbapenemase-resistant Pseudomonas aeruginosa [CRPA]) with the smallest MIC and MBC values against MRSA (3.12 and 25 mg/mL), ESBL- producing E. coli (12.25 and 50 mg/mL), and CRPA (6.25 and 25 mg/mL). This concludes that bitter melon has the potential to be developed as an antibacterial agent, particularly against MRSA strains, ESBL-producing E. coli, and CRPA that cause wound infections. Further in vivo research and the discovery of modes of action are needed to explain the antibacterial effects.
Species of white-tailed forest rats hunted and traded, their conservation status and habitat characteristics, in North Sulawesi, Indonesia
Authors: Laatung Sylvia , Fuah Asnath Maria , Masy'ud Burhanuddin , Sumantri Cece , Dohong Salundik
Published: August 2021

Abstract. Laatung S, Fuah AM, Masy’ud B, Sumantri C, Salundik. 2021. Species of white-tailed forest rats hunted and traded, their conservation status and habitat characteristics, in North Sulawesi, Indonesia. Biodiversitas 22: 2778-2784. The tradition of hunting and trading white-tailed forest rats, especially in North Sulawesi, has been practiced for generations. This poses a threat to the existence of these animals in their natural habitat leading to the extinction of some hunted species. In the past, studies on white-tailed rats being hunted and traded on Sulawesi is still lacking. Therefore, the purpose of this study is to identify the species of white-tailed forest rats hunted and traded, their conservation status and habitat characteristics in North Sulawesi. This study was conducted in April to June 2018 in Minahasa and Bolaang Mongondow District, North Sulawesi. The survey methods used involved visiting hunters, recording and taking pictures of the species of rats being hunted and traded. All samples of white-tailed rats were identified in the Zoological Laboratory, Indonesian Institute of Sciences Cibinong Bogor, West Java. Furthermore, ascertaining the general characteristics of the habitat was carried out using a general survey in locations known as distribution areas in North Sulawesi. The identification of 125 individuals consists of 8 species of white-tailed forest rats from 7 genera, which are commonly hunted. They include Rattus xanthurus (Gray, 1867), Bunomy fratrorum (Thomas, 1896), Lenomys meyeri (Jentink, 1879), Paruromys dominator (Thomas, 1921), Echiotrix leucura (Gray, 1879), Taeromys taerae (Sody, 1932), Maxomys hellwaldi (Jentink, 1879) and Maxomys musschenbrooki (Jentink, 1878). Four out of the eight species of white-tailed forest rats are protected species according to the IUCN Redlist. The white-tailed forest rats identified in this study, were caught in secondary forest and plantation, ranging from an altitude of 500 - 1.500 meters above sea level. Their main sources of feed include Areca catechu, Piper aduncum, Ficus spp., and Arenga piñnata.
Fungal Basidiomycete Ceratobasidium theobromae DNA obtained directly from cocoa petioles
Authors: Junaid Muhammad , Guest David , PURWANTARA AGUS
Published: August 2021

Abstract. Junaid M, Purwantara A, Guest G. 2021. Fungal Basidiomycete Ceratobasidium theobromae DNA obtained directly from cocoa petioles. Biodiversitas 22: 2838-2843. Understanding the biology of the fastidious Basidiomycete Ceratobasidium theobromae occupying host-tissue is essential for plant disease management. Direct pathogen DNA extraction from infected plant tissue avoids the need for isolation in artificial media. We report a modified DNA isolation protocol to obtain total plant DNA designed to overcome DNA extraction and isolation problems caused by infected petioles rich in polysaccharides and phenolic substances as a primary source of gummosis. This study examined and compared total plant DNA isolated from petioles high in polysaccharides and polyphenolic compounds using two methods: conventional CTAB lysis buffer and Kits (the standard method), and a new modified CTAB protocol to address these PCR inhibitors. The modified method resulted in higher quality and quantity of C. theobromae crude DNA and amplified PCR product. The modified method produced large quantities of clear, transparent, aqueous DNA-containing lysate (crude DNA) with a clear separation between the upper crude DNA and organic waste layers. Mean DNA absorbance was 1.80, and the lowest DNA yield was 836.6 ng/µl. With the standard method, the blurred, viscous lysate obtained showed signs of gummosis, with poor separation between layers of crude DNA, polysaccharides, protein, and organic waste layers and low yield. Gel electrophoresis indicated poor quality DNA extract. We conclude that this modified method will be valuable for genetic diversity and disease studies in a range of previously challenging plant tissues and their pathogens.
Reproductive traits and spawning activity of striped eel catfish (Plotosidae) in Kolono Bay, Indonesia
Authors: Asriyana Asriyana , Halili Halili
Published: August 2021

Abstract. Asriyana A, Halili H. 2021. Reproductive traits and spawning activity of striped eel catfish (Plotosidae) in Kolono Bay, Indonesia. Biodiversitas 22: 3020-3028. Reproduction is a natural process for a species to ensure its sustainability in nature. This study aimed to investigate the reproductive traits and spawning activity of the striped eel catfish in Kolono Bay, South Konawe District, Southeast Sulawesi, Indonesia. A total of 965 individuals were collected monthly from June 2020 to May 2021 by using bottom experimental gillnets. Spent/spawning stages of the male and female fish were found during the East season (June-August). The proportions of the spent/spawning stages of male and female fish were 60% and 55.56% and the values of the gonadal somatic index were 1.19 ± 0.53 and 2.19 ± 3.47, respectively during the East season, indicate occurring the peak spawning in this season. Females matured gonads more rapidly at 198.3 mm compared to males at 224.5 mm. Female fecundity was 1,730 ± 390 eggs, with an egg diameter of about 0.11-1.35 mm. Striped eel catfish is a total spawner fish that has one mode of egg distribution pattern. During the East season, it needs protection for spawning. The findings will help in designing effective management and developmental strategies to conserve the striped eel catfish population in the future.
Antibacterial and antioxidant potential of ethyl acetate extract from Streptomyces AIA12 and AIA17 isolated from gut of Chanos chanos
Authors: Kurnianto Muhammad Alfid , Kusumaningrum Harsi Dewantari , Lioe Hanifah Nuryani , Chasanah Ekowati
Published: August 2021

Abstract. Kurnianto MA, Kusumaningrum HD, Lioe HN, Chasanah E. 2021. Antibacterial and antioxidant potential of ethyl acetate extract from Streptomyces AIA12 and AIA17 isolated from gut of Chanos chanos. Biodiversitas 22: 3196-3206. Streptomyces has been recognized as a promising and productive source of antibacterial and antioxidant compounds. The phenotypic and genomic characterizations indicated AIA12 and AIA17 are closely related to the S. globisporus ARGB01 and S. misionensis S1-SC15, respectively. Incubation on yeast-malt extract broth for nine days (AIA12) and 11 days (AIA17) proved to be the best growth medium and optimum antibacterial production time for these two strains. Crude-extract of extracellular secondary metabolites, obtained by ethyl acetate extraction, demonstrated broad-spectrum inhibitory activity against Pseudomonas aeruginosa InaCC B52, Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 10876, Escherichia coli ATCC 25922, Salmonella Typhimurium ATCC 14028, and Listeria monocytogenes with minimum inhibitory and minimum bactericidal concentrations from 2.5 to 0.31 and 5.0 to 0.31 mg mL-1, respectively. Evaluation of antioxidant showed AIA17 crude-extract had moderate DPPH scavenging and antioxidant activities of 65.122% ± 0.56 and 28.178 ± 0.24 mg ascorbic acid equivalent antioxidant capacity (AEAC g-1), respectively. The identification of compounds through profiling with RP-HPLC showed optimum absorbance at 210 and 214 nm, which showed the presence of peptide groups in the constituent compounds' molecular structure. These findings indicate that Chanos chanos-derived Streptomyces produces valuable bioactive compounds with various promising biological activities.
Short Communication: Note on the genus Dorstenia Plum. ex L. (Moraceae) in Java (Indonesia) and noteworthy information on the identity of D. bahiensis through ITS sequence
Authors: Irsyam Arifin Surya Dwipa , Hariri Muhammad Rifqi , PENIWIDIYANTI PENIWIDIYANTI , Irwanto Rina Ratnasih
Published: August 2021

Abstract. Irsyam ASD, Hariri MR, Peniwidiyanti, Irwanto RR. 2021. Short Communication: Note on the genus Dorstenia Plum. ex L. (Moraceae) in Java (Indonesia) and noteworthy information on the identity of D. bahiensis through ITS sequence. Biodiversitas 22: 3358-3363. Dorstenia Plum. ex L. grouped within tribe Dorstenieae in the Moraceae. The genus comprises 105 species that are distributed in the African, Asian, and Neotropical regions. Previous studies showed that Java Island has only one species of Dorstenia, namely D. contrajerva L. This exotic species was introduced a long time ago and naturalized in Java. The field survey was carried out in Banten, Jakarta, West Java, and East Java. Herbarium study was also carried out in Herbarium Bogoriense and Herbarium Bandungense. There are two additional species from Java, D. bahiensis Klotzsch ex Fisch. and C.A. Mey. and D. foetida (Forssk.) Schweinf. Dorstenia bahiensis originated from Eastern Brazil and was found naturalized in Mekarwangi Village, Lembang, Bandung Barat regency, Indonesia. Dorstenia foetida is native to Africa and is only found as a popular cultivated plant. A molecular approach was carried out to provide the right identity of D. bahiensis because it has been mistakenly labeled as D. elata by a Javanese horticulturist. The internal transcribed spacer (ITS) sequence separated and distinguished both D. bahiensis and D. elata into different clades, which makes the popular name for D. elata actually D. bahiensis. Based on this study, there are three species of exotic Dorstenia in Java. The descriptions, photographs, and further discussions are provided.
Invasion of fall armyworm Spodoptera frugiperda, a new invasive pest, alters native herbivore attack intensity and natural enemy diversity
Authors: Rizali Akhmad , Oktaviyani Oktaviyani , Putri Sachristy , Doananda Meygalintang , Linggani Asti
Published: August 2021

Abstract. Rizali A, Oktaviyani, Putri SDPS, Doananda M, Linggani A. 2021. Invasion of fall armyworm Spodoptera frugiperda, a new invasive pest, alters native herbivore attack intensity and natural enemy diversity. Biodiversitas 22: 3482-3488. A new invasive alien pest, fall armyworm Spodoptera frugiperda has been reported widely spread in Indonesia since 2019 and can cause a serious problem in maize cultivation. Its invasion of new habitat may severely impact not only maize production but also native biodiversity including other native pests. This research was aimed to investigate the effect of S. frugiperda invasion on the attack intensity of native herbivores as well as the diversity of natural enemies in maize fields. Field research was conducted in twelve maize fields spread across the district of Malang, Kediri, and Batu, East Java, Indonesia. In each maize field, sampling of S. frugiperda and other insects was conducted by the hand-picking method within four transects with each transect consisting of 100 plants. The results found five species of lepidopteran pests including S. frugiperda, Ostrinia furnacalis, Helicoverpa armigera, Mycalesis sp, and Chrysodeixes sp. S. frugiperda was found with higher attack intensity than other lepidopteran pests. Based on the analysis, the attack intensity of S. frugiperda had a positive relationship with pesticide application and was marginally correlated with plant age and elevation. The infestation of S. frugiperda significantly reduced the attack intensity of other lepidopteran pests as well as the diversity of natural enemies, especially predators. Two native species of parasitoid wasps, Telenomus sp and Mymaridae sp were recorded parasitizing the eggs of S. frugiperda. In conclusion, the infestation of S. frugiperda causes biotic homogenization in the maize field by directly compete with other lepidopteran pests and indirectly eliminate the natural enemy diversity.
Management of parapharyngeal space cavernous sinus haemangioma using transoral robotic surgery
Authors: Fleet M , Healey S , Korampalli S , Moor JW
Published: August 2021

Cavernous haemangiomas are a very rare occurrence in the parapharyngeal space (PPS). Here, we present a case of a 58-year-old woman with an incidentally identified left PPS mass thought to be a pleomorphic adenoma that underwent excision by transoral robotic surgery (TORS). Intraoperative findings demonstrated no solid mass present and histological assessment of resected tissue confirmed a cavernous haemangioma. We discuss our experience in the management of a radiological and surgical mismatch of a PPS mass in what we believe to be the first cavernous haemangioma to be excised by TORS in this region.
Eosinophilic Granulomatosis with Polyangiitis that was Difficult to Distinguish from Peroneal Nerve Palsy and Lumbar Disc Herniation: A Case Report
Authors: Kumahara Ryotaro , Kudo Hitoshi , Inoue Ryo , Fukuda Akira , Ota Seiya , Ishibashi Yasuyuki
Published: August 2021

Introduction: Eosinophilic granulomatosis with polyangiitis (EGPA) patients with mononeuropathy multiplex often visit orthopedic clinics; however, orthopedic surgeons have limited experience in diagnosing EGPA because of its rarity. We report a case of EGPA that required 1 month to confirm the diagnosis.
Case Report: A 48-year-old woman presented with acute onset numbness in the right lower extremity. She had muscle weakness of the right lower extremity; lumbar spine magnetic resonance imaging showed lumbar disc herniation. Despite conservative treatment, her symptoms worsened. Blood tests showed increased eosinophils and serum IgE. She was diagnosed with EGPA, which should be considered in case of atypical paralytic symptoms.
Conclusion: EGPA is so difficult to diagnose. In our case, the symptoms worsened on the 30th day after the initial visit. She was diagnosed with EGPA by a blood test at the time of admission. If patients with bronchial asthma or a history of allergies develop lumbar radiculopathy or peroneal nerve palsy-like symptoms, EGPA should be considered, and steroid treatment should be initiated early.
Keywords: Eosinophilic granulomatosis with polyangiitis, peroneal nerve palsy, lumbar disc herniation, asthma.
Soil development on Proterozoic and Paleozoic rocks of central Bohemia
Authors: Zigova Anna
Published: August 2021

The character of modern pedogenesis in the territory of the Brdská and Křivoklátská vrchovina Highlands was studied on silicate rocks such as Paleozoic granite and Proterozoic mudstone and greywacke. The parent materials were evaluated on the basis of petrography, X-ray diffractometry of powder samples of rock forming and heavy minerals. The soils were described as for their macromorphological characterics and the results of a variety of analyses of organic and anorganic components. Pedogenesis proceeded in acid conditions. The values of base saturation are mostly below 50 % for the Ah horizons. The intensity of soil development on individual parent material decreases in the order: mudstone (Ah-AhBw-Bw-C)granite (Oi-Oe-Oa-Ah-Bw-C)greywacke 1 (Oi-Oe-Oa-Ah-AhC-C)greywacke 2 (Oi-Oe-Oa-Ah-C). The process of humification was documented at all study sites. Evidence of pedogenetic alteration is present in soils developed on granite and mudstone. High amounts of chlorite and elevated contents of illite are characteristic for Cambic Leptosols (Dystric, Skeletic) on mudstone. Weddellite and whewellite were found in relatively large amounts in O horizons of soils except for the Červený kríž site. The predominant from of calcium oxalate minerals at these sites is whewellite. Weddellite occurs in small amount, which is probably due to its lower stability.
Temporal prepulse contrast degradation in high-intensity CPA lasers from anisotropy of amplifier gain media
Authors: Cupal Josef , Spinka Thomas , Sistrunk Emily , Rus Bedřich , Häfner Constantin
Published: August 2021

We present a study of the temporal prepulse contrast degradation of
high focused intensity pulses produced in CPA laser systems due to
imperfections in amplifier design, alignment of amplifier components,
and crystal inhomogeneity. Using an extended cross-polarized imaging
technique, we demonstrate the presence of multiple crystal domains
inside Ti:sapphire slabs with

≈

10

c
m

diameter. The results of our
numerical calculations show that crystalline c-axis orientation
inhomogeneity caused by these crystal domains can lead to the
generation of prepulses with a relative contrast of

>

10

−
10

within several picoseconds before the
main pulse. In a multiple-slab amplifier head configuration sometimes
used in high-repetition-rate systems, the misalignment of the
crystalline c-axes of the amplifier slab with respect to each other
can lead to the generation of prepulses with relative contrast as high
as

10

−
6

, depending on the magnitude of
misalignment.
Underwater image recovery utilizing polarimetric imaging based on neural networks
Authors: Zhang Ran , Gui Xinyuan , Cheng Haoyuan , Chu Jinkui
Published: August 2021

Underwater imaging faces challenges due to complex optical properties in water. Our
purpose is to explore the application of polarimetric imaging in image
recovery under turbid water based on deep learning. A polarization
camera is used to capture the polarization images of objects under
water as datasets. The method used in our study aims to explore a
structure and loss function that is suitable for the model. In terms
of the model structure, four pairs of models consisting of polarized
version and gray version based on the idea of dense U-Net and
information flow were proposed. In the aspect of loss function, the
method of combining weighted mean squared error with perceptual loss
was proposed and a proper set of loss weights was selected through
comparison experiments. Comparing the model outputs, it is found that
adding polarized information along with the light intensity
information to the model at the very front of the model structure
brings about better recovering image. The model structure proposed can
be used for image recovery in turbid water or other scattering
environments. Since the polarization characteristics are considered,
the recovered image has more detailed features than that where only
intensity is considered. The results of comparison with other methods
show the effectiveness of the proposed method.
Stereoscopic particle image velocimetry in inhomogeneous refractive index fields of combustion flows
Authors: Vanselow C. , Hoppe O. , Stöbener D. , Fischer A.
Published: August 2021

Particle image velocimetry (PIV) measurements in reactive flows are
disturbed by inhomogeneous refractive index fields, which cause
measurement deviations in particle positions due to light refraction.
The resulting measurement errors are known for standard PIV, but the
measurement errors for stereoscopic PIV are still unknown. Therefore,
for comparison, the velocity errors for standard and stereoscopic PIV
are analyzed in premixed propane flames with different Reynolds
numbers. For this purpose, ray-tracing simulations based on the
time-averaged inhomogeneous refractive index fields of the studied
non-swirled flame flows measured by the background-oriented Schlieren
technique are performed to quantify the resulting position errors of
the particles. In addition, the performance of the volumetric
self-calibration relevant to tomographic PIV is analyzed with respect
to the remaining position errors of the particles within the flames.
The position errors cause significant standard PIV errors of 2% for
the velocity component radial to the burner symmetry axis.
Stereoscopic PIV measurements result in measurement errors of up to 3%
radial to the burner axis and 13% for the velocity component
perpendicular to the measurement plane. Due to the lower refractive
index gradients in the axial direction, no significant velocity errors
are observed for the axial velocity component. For the investigated
flame configurations, the position errors and velocity errors increase
with the Reynolds numbers. However, this dependence needs to be
verified for other flame configurations such as swirled flame
flows.
Mid-infrared multispectral confocal microscope using off-axis parabolic mirrors to study epiretinal membranes
Authors: Zhu Jiaying , Wang Ruixing , Liu Qiao , Luo Zhifu , Tian Bei , Zhu Li-Guo
Published: August 2021

Mid-infrared (mid-IR) multispectral microscopy, especially operating at the wavelength of 5–11 µm, is an effective tool for detecting, identifying, and quantifying the structure and composition of biological tissues. Compared with that based on the optical lens, the mid-infrared microscope composed of off-axis parabolic (OAP) mirrors is low cost, simple, and suitable for longer range of wavelength without chromatic aberrations, while keeping the optical transmission efficiency. Here we report a compact and versatile mid-infrared multispectral confocal microscope based on off-axis parabolic mirrors. We also perform numerical calculations based on the vectorial diffraction theory on OAP mirrors and analyze the typical aberrations and misalignment of the OAP-based optical system. Finally, we perform multispectral imaging of the epiretinal membrane of the human eyes with the spectrum selected according to its resonance absorption peak. The system is designed to perform multispectral or even hyperspectral imaging to identify and predict potential disease.
Monitoring subcutaneous tumors using Mueller polarimetry: study on two types of tumors
Authors: Varin Briséis , Rehbinder Jean , Dellinger Jean , Heinrich Christian , Torzynski Marc , Spenlé Caroline , Bagnard Dominique , Zallat Jihad
Published: August 2021

A better understanding of tumor development is crucial for treating cancer. Polarimetric imaging is an interesting alternative for monitoring subcutaneous tumors as it is non-invasive. In this study, a Mueller spectro-polarimeter is used to monitor tumor development on mice injected with non-pigmented breast cancer cells or with pigmented murine melanoma cells. Three stages of non-pigmented tumor development are revealed with three polarimetric parameters. These stages also appear for pigmented tumors, although less clearly. A halo of high depolarization surrounding the non-pigmented tumor in the first stage allows the outlining of the tumor. Considering polarimetric parameters, a biological interpretation is proposed.
Polarization-insensitive interferometer based on a hybrid integrated planar light-wave circuit
Authors: Zhang Guo-Wei , Ding Yu-Yang , Chen Wei , Wang Fang-Xiang , Ye Peng , Huang Guan-Zhong , Wang Shuang , Yin Zhen-Qiang , An Jun-Ming , Guo Guang-Can , Han Zheng-Fu
Published: August 2021

Interferometers are essential elements in classical and quantum optical systems. The strictly required stability when extracting the phase of photons is vulnerable to polarization variation and phase shift induced by environment disturbance. Here, we implement polarization-insensitive interferometers by combining silica planar light-wave circuit chips and Faraday rotator mirrors. Two asymmetric interferometers with temperature controllers are connected in series to evaluate the single-photon interference. Average interference visibility over 12 h is above 99%, and the variations are less than 0.5%, even with active random polarization disturbance. The experiment results verify that the hybrid chip is available for high-demand applications like quantum key distribution and entanglement measurement.
Ich sehe was, was du auch siehst. Über die Möglichkeiten von Augmented und Virtual Reality für die digitale Beteiligung von Bürger:innen in der Bau- und Stadtplanung
Authors: Fegert Jonas , Pfeiffer Jella , Reitzer Pauline , Götz Tobias , Hariharan Anuja , Pfeiffer-Leßmann Nadine , Renner Patrick , Pfeiffer Thies , Weinhardt Christof
Published: August 2021

Digital Government eröffnet Möglichkeiten, Verwaltungs- und Regierungsprozesse kritisch zu reflektieren und sie entsprechend neu zu denken. Oblagen Bürgerbeteiligungsprozesse in der Vergangenheit zahlreichen Hürden, bietet die e‑Partizipation Möglichkeiten, sie mit modernen Technologien zu verbinden, die eine niedrigschwellige Teilhabe ermöglichen. In dem Forschungsprojekt Take Part, gefördert durch das Bundesministerium für Bildung und Forschung, werden innovative Formen der Beteiligung von Bürger:innen in der Stadt- und Bauplanung mithilfe von Augmented und Virtual Reality (AR und VR) erforscht. Dabei geht es vor allem darum, neue Anreize zu schaffen, Bürger:innen zur Beteiligung zu motivieren und durch diese das Konfliktpotential um Bauprojekte zu reduzieren. Mithilfe der innerhalb von Take Part entwickelten App können Bürger:innen Bauvorhaben diskutieren, Feedback geben oder über sie abstimmen, während sie dabei den Beteiligungsgegenstand anschaulich in AR und VR präsentiert bekommen. Zugleich können auch Initiator:innen mithilfe eines Partizipationsökosystems die Beteiligung im jeweiligen Bauvorhaben konfigurieren, indem sie sowohl vorhandene Module kombinieren und konfigurieren, als auch passende Dienstleistungen, wie beispielsweise 3D-Modellierungen, einkaufen. In diesem Beitrag sollen die konkreten technologischen Entwicklungen (u. a. Outdoor-AR-Tracking und räumlich verankerte Diskussionen), sowie das Partizipationsökosystem (Dienstentwicklungs- und Ausführungsplattform) vorgestellt werden. Erstmalig soll so der entwickelte Prototyp umfassend dargestellt werden. Auf die Herausforderung, eine e‑Partizipations-App zu entwickeln, die die Möglichkeit bietet, verschiedene Interaktionskonzepte ineinander zu integrieren und gleichzeitig eine überzeugende User-Experience bietet, soll ebenfalls eingegangen werden. Anschließend wird das Potenzial einer solchen Lösung für die digitale Mitbestimmung in lokaler Verwaltung vor allem in Bezug auf gesteigerte Vorstellungskraft und Motivation zur Teilhabe für Nutzer:innen diskutiert und in den Kontext der Covid-19 Pandemie gesetzt.