bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Utility of Neutrophil to Lymphocyte Ratio in Sickle Cell Disease With Vaso-Occlusive Crisis
Authors: Maharaj Satish , Chang Simone
Published: January 2023

Background and objectives:

The neutrophil-to-lymphocyte ratio represents a universally accessible value that correlates with inflammation and prognosis in several disease states; however, the role of this biomarker in sickle cell disease remains poorly explored. Hence, the objective of the present study was to determine its potential clinical utility in patients with sickle cell disease.

Patients:

Herein, we retrospectively reviewed 143 patients with sickle cell disease who presented to the emergency department with fever and painful vaso-occlusive crisis.

Results:

The examined cohort had a prevalence of 11% confirmed bacterial infection, with approximately two-thirds reporting the use of hydroxyurea. The neutrophil-to-lymphocyte ratio was lowest in the vaso-occlusive crisis-only group when compared with all other groups; this ratio was the highest in those with a confirmed bacterial infection. Patients with confirmed bacterial infection experienced the longest mean length of in-hospital stay, approximately 2 weeks, whereas patients with viral infections and vaso-occlusive crisis had the shortest stay (4–5 days). An elevated neutrophil-to- lymphocyte ratio on presentation correlated with confirmed bacterial infection (area under the curve 0.76); maximum specificity (76%) and sensitivity (69%) for confirmed bacterial infection were achieved using a neutrophil-to-lymphocyte ratio threshold ≥4.6. However, the neutrophil-to-lymphocyte ratio did not predict acute chest syndrome in this patient cohort.

Conclusion:

The neutrophil-to-lymphocyte ratio is a promising biomarker in sickle cell disease with diagnostic and prognostic utility.
Programa Nacional de Consensos Inter-Sociedades
Authors: Varios
Published: January 2023

Convocadas por la Academia Nacional de Medicina, por intermedio del Instituto de Estudios Oncológicos, ante la iniciativa de la Asociación Argentina de Ginecología Oncológica, las entidades autoras, miembros del Programa Argentino de Consensos de Enfermedades Oncológicas y del Programa

Nacional de Consensos Inter-Sociedades, avalan este Consenso Multidisciplinario, que aúna los criterios propuestos por los profesionales que se encuentran involucrados en la prevención, diagnóstico y tratamiento de los tumores de cuello uterino.

Las Instituciones autoras se comprometen a difundir y promover el uso del contenido de este documento en todas las áreas y entidades responsables del manejo de la Salud, Institutos Nacionales,

Provinciales, Municipales, PAMI, Colegios Médicos, entidades de Medicina Prepaga, Obras Sociales, Mutuales, Superintendencia de Seguros de Salud de la Nación, Hospitales de Comunidad, Hospitales Universitarios, demás entidades relacionadas y su aplicación por todos los especialistas del país.

Dedicado a la memoria de la Dra. Ana María Álvarez
Preprocessing: A method For Reducing Time Complexity
Authors: Abbas Mubarak  , Sajid Iqbal  , Qaisar Rasool  , Nabeel Asghar  , Neetu Faujdar  , Abdul Rauf
Published: January 2023

Data can be processed quickly if it is in some order, whereas unsequenced data can take more time to obtain results. Sorting is used for data arrangement. It is also one of the essential requirement for most applications and this step helps to boost performance. Sorting is also a prerequisite in several computer applications like databases. Over time computer scientists have not only introduced new sorting techniques considering various factors to be improved but they have also presented enhanced variants of existing sorting methods. The main objective has always been to reduce the execution time and space of the sorting algorithms. With every passing day, digital content is growing rapidly, which is a significant cause that encourages researchers to design new time-space efficient sorting algorithms. This paper presents some preprocessing strategies for quicksort and insertion sort to improve their performances. Tha main idea of using these preprocessings is to make input data more suitable for sorting algorithm, as most sorting function performs extraordinary for a specific type of input, such as insertion sort works better on nearyly sorted data. To authenticate the efficiency of existing sorting algorithms, these have been compared with proposed preprocessing strategies. The results with proposed techniqes outperforms the results of original sorting methods. It also helps to convert worst case into average case. By using this approch complexity of many algorithms can be reduced, therfore this is very important.
Play-based mathematical activities at the ages of infancy: a case study at a nursery school.
Authors: Panaoura Areti , Petrou Pavlina
Published: January 2023

The development of mathematical skills at the children’s first years of life is usually examined by psychologists. For the development of those skills the appropriate experiences are needed. The present case study, as part of a project, in the domain of mathematics education, examined the role of structured play – based activities on the development of infants’ (11 months to two years old) first mathematical experiences. We examined infants’ behaviour during the activities and their nursery teachers’ and parents’ respective behaviour. We asked their parents to share with us the daily activities with their children which they believed that were related with mathematics. Results indicated that usually play-based activities fulfil the infant’s interest and motivation to participate actively. Play and math can be a powerful and dynamic combination of learning with the contribution of nursery teachers and parents under an informal and nonformal framework. However, a comprehensive teaching model or a Curriculum will facilitate nursery teachers to develop and implement play – based activities in mathematics with higher self-efficacy beliefs and consequently they would be able to guide respectively the infants’ parents.
Equal sign representations in curriculum and textbooks in middle schools and students’ understanding of equal sign
Authors: Çaksen Beyzanur , Özel Serkan
Published: January 2023

The aim of the current study was to investigate fourth and fifth grade students’ equal sign conceptions in the light of the revised Turkish mathematics curriculum (MoNE, 2018) that includes newly added objectives related to the equal sign concept in fourth grade. A total of 53 students (30 fourth-grade students) participated in the study. Equal sign test (EST) was used for quantitative data collection. Semi-structured interviews were conducted to gain a deeper insight into the students’ equal sign conceptions. Moreover, the fourth and fifth grade students’ textbooks and other course materials were analysed in terms of equal sign contextual presentations. According to the quantitative analysis results, the average score of fifth-grade students was 11.21 whereas the fourth-grade students’ average score was 8.13 out of 13 in the EST. The analysis of the course materials displayed that standard contextual presentations of the equal sign, which are only helpful for teaching the operational view, have higher frequencies in fourth grade, whereas non-standard presentations are dramatically high in fifth grade. The results of the semi-structured interviews supported that both the fourth and fifth grade students have some misunderstandings of the relational meaning according to the error patterns found in the EST results.
Genome-wide association study for loin muscle area of commercial crossbred pigs
Authors: Luan Menghao , Ruan Donglin , Qiu Yibin , Ye Yong , Zhou Shenping , Yang Jifei , Sun Ying , Ma Fucai , Wu Zhenfang , Yang Jie , Yang Ming , Zheng Enqin , Cai Gengyuan , Huang Sixiu
Published: January 2023

Objective: Loin muscle area (LMA) is an important target trait of pig breeding. This study aimed to identify single nucleotide polymorphisms (SNPs) and genes associated with LMA in the Duroc×(Landrace×Yorkshire) crossbred pigs (DLY).Methods: A genome-wide association study was performed using the Illumina 50K chip to map the genetic marker and genes associated with LMA in 511 DLY pigs (255 boars and 256 sows).Results: After quality control, we detected 35,426 SNPs, including six SNPs significantly associated with LMA in pigs, with MARC0094338 and ASGA0072817 being the two key SNPs responsible for 1.77% and 2.48% of the phenotypic variance of LMA, respectively. Based on previous research, we determined two candidate genes (growth hormone receptor [GHR] and 3-oxoacid Co A-transferase 1 [OXCT1]) that are associated with fat deposition and muscle growth and found further additional genes (MYOCD, ARHGAP44, ELAC2, MAP2K4, FBXO4, FBLL1, RARS1, SLIT3, and RANK3) that are presumed to have an effect on LMA.Conclusion: This study contributes to the identification of the mutation that underlies quantitative trait loci associated with LMA and to future pig breeding programs based on marker-assisted selection. Further studies are needed to elucidate the role of the identified candidate genes in the physiological processes involved in LMA regulation.
Suicide in Switzerland: why gun ownership can be deadly
Authors: Stroebe Wolfgang
Published: January 2023

There is a great deal of empirical evidence that owning a firearm increases the risk of dying from suicide. Most suicides are impulsive. Nearly 50% of survivors of suicide attempts report that they took less than 10 minutes between the decision to die and their suicide attempt. The great majority of these suicide survivors never make another attempt and die of natural causes. Because nearly 90% of firearm suicide attempts have a deadly outcome, gun owners are unlikely to have such a second chance. These impulsive suicide attempts are typically carried out with the means at hand. Swiss men have much higher firearm suicide rates than men in other European countries and this excess is likely to be due to their easy access to guns, because army conscripts have to keep their guns at home. When the number of conscripts was nearly halved in 2003/4 as a result of the Swiss Army Reform XXI, the number of army-issued firearms was reduced by an estimated 20%. An analysis of suicide rates before and after the reform indicated that male (but not female) suicide rates decreased by 8%, with no evidence of substitution with other means of suicide. If the army would require that the remaining half of conscripts had to keep their weapons at their barracks rather than at home, a further decrease in male suicide rates could be expected.
Die allgemeine Informationspflicht des reformierten Code civil
Authors: Ernst Simone I. J.
Published: January 2023

Insight into an important aspect of the French reform of the law of obligations of 2016. The development of the topic in France is examined and in particular the standardization of a general pre-contractual duty to inform, with which pioneering work was done. It is taken into account that information duties do not only have a preventive effect, but are multifunctional and that a distribution of the information risk is often achieved indirectly. This is illustrated by a comparative legal analysis based on facts from case law under the law of sales, which shows the different handling of the problem in German law, UN sales law and CESL.
Arbeitszeitrechtliche Vorgaben und Vereinbarungen für Lizenzfußballer
Authors: Wilhelm Jan
Published: January 2023

Licensed soccer players are not typical employees, as their constant striving for top sporting performance runs counter to state restrictions on working hours. This raises the question of whether and to what extent protective provisions under labor law apply at all to professional soccer players. Does the state have a duty to protect in this area at all? Or can the licensed clubs take over any health protection measures, so that regulation through working time regulations is obsolete?

In addition, the study examines which contractual regulations are applicable at all. Existing model employment contracts for licensed players do not stipulate any working time requirements. Is this a problem in practice?
Blockchain-Netzwerke und Krypto-Token im Internationalen Privatrecht
Authors: Drögemüller Jonas
Published: January 2023

The study offers a comprehensive examination of the law applicable to blockchain networks and crypto assets. The objective is to find out whether private international law, which traditionally searches for the 'seat' of a legal relationship, is able to capture these inherently transnational phenomena. The focus is on the one hand on the legal relationships between the participants of blockchain networks, and on the other hand on the legal transactions under the law of obligations and in rem in connection with the issuance and trading of crypto assets. The study also considers the recent reform of German (international) securities law by the eWpG. Finally, it develops a proposal for a future blockchain-specific conflict-of-laws rule.
Biopolitik und Recht
Authors: Faets Simon
Published: January 2023

Am Grund des modernen Rechts liegt ein Widerspruch: Es soll die Gleichheit aller verwirklichen und produziert zugleich permanent Ausschlüsse und Gewalt. Das Leben von Geflüchteten scheint für nationalstaatliche Rechtssysteme beispielsweise weniger schützenswert zu sein als das Leben der eigenen Staatsbürger:innen. Die in diesem Buch vorgelegte Kritik des Rechts setzt daher bei den Ausgeschlossenen an und entwickelt ausgehend von der Kritischen Theorie und im Anschluss an poststrukturalistische und postkoloniale Ansätze eine biopolitische Theorie des Widerstands der Ausgeschlossenen. Simon Faets arbeitet und forscht am Schnittpunkt von Politischer Philosophie, Sozialphilosophie und Christlicher Sozialethik.
Deutschland und Frankreich schaffen das
Authors: Braouet Christophe
Published: January 2023

60 years of the Franco-German Treaty of Friendship—an opportunity to celebrate the progress we have made together. Courageous decisions and joint efforts have made peace possible and furthered European integration. But current crises, nationalist movements, a divided political population and a lack of civil interest in a European community threaten to undermine this cooperation.

In this book, Christophe Braouet argues that a strong Europe and the social market economy should continue to be supported, not by countries going it alone but through joint efforts.

Well-being should become the political yardstick with which to regain the interest of civil society.

After studying economics and political science at Sciences Po, Christophe Braouet worked for many years in banking in France and Germany. As the child of German-French parents, he is a dual citizen and, as President of the Franco-German Society Frankfurt, has been working for understanding between the peoples since 2004. He was also a member of the University Council of the Franco-German University and is a board member of the Franco-German Institute Ludwigsburg (dfi).
Plasma Volume Variations in Professional Soccer Players: Difference Between Pre- and Competitive Season
Authors: Ben Abderrahman Abderraouf , Jebabli Nidhal , Rhibi Fatma , Rivière Fabien , Le Moal Emmeran , Laher Ismail , Zouhal Hassane
Published: January 2023

Background: Variations in plasma volume and hematological parameters occur before and after training in soccer players. However, there are no reports on changes in hematological parameters resulting from a half-season of training in professional soccer players. Objectives: To investigate the effects of training load on plasma volume variations in elite soccer players. Methods: Twenty soccer players from the 1st French division soccer league (Ligue 1) were included in the study. The training load was evaluated using the rating of perceived exertion (RPE, 10- Borg scale) after each training session and each match. Anthropometrics characteristics, hematocrit (Ht), hemoglobin (Hb) and plasma volume variations (PVV) were assessed at 3 different times: T1: Baseline (before the first week of pre-season), T2: At the end of pre-season (after 8 weeks of training) and T3: At the end of the first competitive period (after 26 weeks of training and at halfway of the competitive season). Results: Values of Ht and lean body mass (LBM) increased during the first competitive period from T1 to T3 (Ht: ∆↑8%, P = 0.037, effect sizes (ES) = 1.0; LBM: ∆↑4%, P = 0.041, ES = 0.83) and from T2 to T3 (LBM: (∆↑2%; P = 0.05; ES = 0.77). Moreover, PVV decreased from T2 to T3 (P = 0.002, ES = 0.5) and from T1 to T3 (P < 0.05; ES = 1.26). There were no differences in Hb at T1, T2 or T3. Conclusions: Changes in body weights, PVV and Ht during preparatory and competitive phases were affected by the training load and competitive play.
Upaya Meningkatkan Keterampilan Menulis dengan Metode Pembelajaran Picture And Picture Di Sekolah Dasar
Authors: Andian Puteri Desty , Sadhono Kundharu , Rakhmawati Ani
Published: January 2023

Kemampuan berbahasa meliputi aspek mendengar, membaca, menulis, dan berbicara. Banyak siswa yang merasa kesulitan dalam mengembangkan aspek menulis. Terutama dalam merangkai kata-kata untuk dapat disusun menjadi suatu kalimat. Maka dari itu penulis ingin meningkatkan keterampilan menulis pada siswa kelas V SDN 01 Ngadiluwih dengan menggunakan metode pembelajaran Picture and Picture. Penelitian ini merupakan penelitian tindakan kelas yang dilakukan secara langsung atau luring. Hasil yang didapatkan model pembelajaran Picture and Picture mampu memantik siswa untuk berpikir kreatif dalam mengubah potongan-potongan gambar menjadi sebuah cerita.
A review of the Oral Cancer Referral Pathway System in the Dublin Dental University Hospital
Authors: Cheng Joshua , Maher Fiachra , Pierse Dermot
Published: January 2023

##Introduction:

The incidence of oral and oropharyngeal cancer in Ireland is increasing with approximately 503 cases diagnosed annually. A delay in diagnosis for oral cancer leads to advancement in tumour staging which increases the risk of mortality by up to 2-fold. Early detection contributes to the reduction of morbidity and improvement of survival rates.

##Aim:

This review aims to assess the sources of referral and evaluate the efficiency of DDUH’s oral cancer referral pathway system.

##Methods:

A retrospective search was carried out through the hospital’s electronic dental records (EDR) of patients from 1st of January to 31st of December 2019. Patients who received a histological diagnosis of oral cancer from biopsies carried out were identified and their EDR accessed.

##Results:

In 2019, there were 65 confirmed diagnoses of oral cancer in the Dublin Dental University Hospital (DDUH) of which majority (89%) of the cases were assessed within 2 weeks. A large proportion (89%) received the diagnosis within a month from the referral date. The primary cause of delay in the clinical pathway is the delay in patients presenting to primary care. Only 50% of patients with symptoms synonymous with oral cancer presented to primary care within 4 weeks.

##Conclusion:

The ‘open door’ policy adopted by the DDUH is beneficial in terms of direct access, reducing waiting time and allows for early detection of oral cancer which helps reduce morbidities and improve the overall survival rates of oral cancer cases.
Quality Assessment and Review of Online Information relating to Third Molar Pain and Removal
Authors: Mulvihill Ciara , O’Donoghue Gabrielle , Pierse Dermot
Published: January 2023

##Statement of the problem:

Dental professionals have embraced the internet as a means to enhance patient care

and optimise access to dental services. However, dental information present on the internet is unregulated and varies in quality, accuracy and readability.

##Purpose of the study:

This paper aims to assess the quality of the information online relating to third molars.

Materials and methods: Two key terms (wisdom tooth pain and wisdom tooth extraction) were entered into Google, Yahoo and Bing search engines. Websites were assessed using the DISCERN and the HoNCode instruments.

##Results:

A total of 60 websites were assessed. 2 websites were excluded in accordance with the exclusion criteria and 15 duplicate websites were excluded, leaving 43 unique sites. In the websites addressing “wisdom tooth pain” the average HoNCode score awarded was 40% (range 13-72%) while the average DISCERN score awarded was 43(range 24-70). In the websites addressing “wisdom tooth extraction” the average HoNCode score awarded was 35%(range 15-75%) while the average DISCERN score awarded was 35(range 25-69).

##Conclusions:

The overall quality of the websites assessed is fair. This result shows that the reasonable patient may be misinformed by Internet sources on material risks. Clinicians should be aware of tools such as DISCERN and HoNCode and utilise them in the development of online content for their own practice.
A sagittal split osteotomy approach for removal of a large cementoblastoma at the mandibular angle
Authors: Cotter Mar , Khattak Zeeshan G. , Cotter Chris
Published: January 2023

Benign lesions at the angle of mandible are frequently removed by a conventional intra oral approach to gain access and achieve complete visualisation. This method is quick and effective when dealing with small benign lesions that are superficially located at the angle of mandible. The removal of large and deeply located lesions with a conventional intra oral approach however, bring about a unique set of challenges particularly when the third molar is displaced towards the inferior border of mandible including lack of complete visualisation of the lesion, difficulty in identification and protection of the inferior alveolar nerve and necessitating removal of a considerable amount of osseous structure thus increasing the risk of a mandibular fracture. Alternative techniques for such lesions include an extra oral approach but one which could potentially create a cosmetic defect from cutaneous scarring and can result in facial nerve injury.

This case report describes the use of a unilateral sagittal split osteotomy (SSO) in the removal of a mandibular cementoblastoma. This is a safe and effective technique allowing optimal access to the tumor with complete visualisation, identification and protection of the inferior alveolar nerve with minimal bone removal while maintaining mandibular integrity, strength and facial aesthetics.
The risks of smartphone and mobile technology for the dissemination of clinical data by dental professionals
Authors: John Bernadette , McCreary Christine , Roberts Anthony
Published: January 2023

##Statement of the problem:

Smartphone technologies have changed the landscape of digital communication across society. The Covid-19 pandemic has accelerated the adoption of and requirement for technical solutions to facilitate remote clinical communications. Despite the benefits of smartphones in a clinical communication context, there are risks associated with their use.

##Purpose of the study:

The primary purpose of this study was to determine the extent of smartphone use among dental professionals in the Republic of Ireland (ROI). In addition, we sought to determine the perception and knowledge of potential pitfalls, risks, and limitations of these technologies among the same population. A smaller cohort of UK dental professionals was surveyed for comparison.

##Materials and methods:

An online quantitative survey was distributed to evaluate dental professionals’ knowledge and understanding of the risks and limitations of smartphone and mobile technology, providing general understanding of the current use of smartphone technology in healthcare in the ROI and the UK.

##Results:

A total of 123 responses were received from dental professionals in the ROI (UK: n=77). The majority of dental professionals confirmed that they were aware of the risks associated with smartphone use and perceived that they were adequately skilled in digital professionalism. However, concerning practice regarding the communication of sensitive patient data was identified, with the potential for these data to be stored on insecure devices and cloud servers. Many ROI and UK dental professionals confirmed that they would need support to remove patient-identifying data when trading in their device.

##Conclusions:

App, smartphone and mobile device ownership among dental professionals for clinical communications is widespread in the ROI (and UK), with respondents using their devices to send images (photos and radiographs) to one another. However, the risks of such activities are only partly acknowledged, with many having a lack of insight into data security.
Louis Pasteur et les maladies des vers à soie : un regard épistémologique sur les recherches sur la pébrine / Louis Pasteur and the silk worm diseases: an epistemological view on the researches on pebrine
Authors: Debru Claude
Published: January 2023

Pasteur’s works on the silkworm diseases, from 1865 to 1870, were a turning point that allowed him to proceed from microbiology to veterinary and human medicine. Rereading the history of his research from an epistemological point of view allows to show the transition from an erroneous conception of the disease named pebrine to a justified conception of the disease as a contagious one due to a parasite. This transition could take place thanks to the alliance of various, persistently used methods, such as microscopy, comparative statistics, longitudinal observations of the consequences of experimental intoxications, autopsy revealing previously unknown phenomena in the diseased organism. This last method brought the final proof of the infectious character of the disease.
Nécessité d’un changement de paradigme pour étudier la nutrition et la fertilisation azotée des cultures / Need for a paradigm shift to study crop nutrition and nitrogen fertilization
Authors: Lemaire Gilles , Briat Jean-François , Gojon Alain , Gastal François
Published: January 2023

Nitrogen fertilization of crops has long been based on a statistical analysis of the response of their yield to increasing doses of fertilizers. This prognosis has led to an insurance practice applying excessive doses of nitrogen so as not to penalize yields. A method for predicting the nitrogen balance of a crop has been developed to correct this trend but remains too highly imprecise. Diagnosis of the nitrogen nutrition status of a crop has recently emerged, reducing the uncertainty linked to the variability of local conditions. This diagnosis, integrated into decision support algorithms, makes it possible to apply fertilizers only “where” and “when” the nutritional status of the crops requires it. This precision must make it possible to achieve the targeted yields while minimizing the environmental impacts.
La petite exploitation agricole dans l’espace rural européen. Retour sur une figure controversée / The small farm in the European countryside. A look back at a controversial figure
Authors: Maurel Marie-Claude
Published: January 2023

Once considered to be on the verge of extinction, small-scale farming is regaining legitimacy through its contribution to the supply of fresh food via proximity relations. This note attempts to revisit conceptual and theoretical approaches by positioning the small farm in itshistory and context. New and recent typological studies show the great diversity of this social form in the European countryside. The attention paid to the social realities of the coming back of small-scale farming in Central and Eastern Europe, by decentring the gaze, enables to introduce other elements of analysis than those generally put forward.
Changement climatique et systèmes alimentaires : de la nécessité de la transition agroécologique / Climate Change and food systems
Authors: Rastoin Jean-Louis
Published: January 2023

The global food system is the source of one third of the emissions of the main greenhouse gases (carbon dioxide, methane, nitrogen dioxide). The negative externalities of climate change on the food system concern the volume of production, the quality of products, the socio-economic conditions of people. A provisional assessment of foresight exercises carried out on food systems makes it possible to identify the dead ends of the trend scenarios (spatial amplification of the agro-industrial model) and the probable advantages of a rupture scenario based on sustainable territorialized food systems. To implement this transition, three levers should be mobilized: (1) an in-depth modification of diets and technical and economic production paths, (2) a reconfiguration of knowledge chains, (3) a partnership governance system with effective incentives (investments and taxation) for all actors of the global food system.
Un bon croquis vaut mieux qu’un long discours ? / A good sketch is better than a long speech?
Authors: Juvin Judith , Belhomme Marie-Charlotte , Castex Stéphanie , Bliard Christophe , Haudrechy Arnaud
Published: January 2023

Napoleon Bonaparte once said, “A good sketch is better than a long speech”. Though an ardent promoter of beet sugar production, Napoleon could never have imagined that he was describing the thorny problem of the stereochemical representation of sugars. Drawing the structure of a sugar molecule (also called “carbohydrate”) means addressing the challenge of unambiguously transcribing a three-dimensional reality into a bi-dimensional representation as accurately as possible. Since Emil Fischer's initial proposals, several methods have been suggested, with their advantages and drawbacks. Consequently, selecting a particular approach is far from inconsequential and involves numerous pitfalls. The objective of this document is to raise awareness of the subtleties of sugar molecules representations.
Entre el ego de la imagen y el ego humano. La voz media como modelo de la agencia de la imagen
Authors: Belgrano Mateo
Published: January 2023

A partir del llamado giro icónico o giro pictórico, han aparecido múltiples autores que llaman la atención sobre el poder o agencia de las imágenes y el efecto performativo que tienen en sus espectadores. En este trabajo me concentraré particularmente en la teoría de los actos icónicos de Horst Bredekamp. La imagen no es un objeto pasivo ante la mirada del otro, sino que, por el contrario, tiene una agencia propia capaz de determinar el comportamiento y las emociones de quien la mira. Sin embargo, este énfasis en la agencia de la imagen pone en un segundo plano, o en uno casi inexistente, el rol del artista. ¿La intencionalidad del diseñador no juega ningún papel en cómo el artefacto produce efectos “en los sentimientos, pensamientos y acciones de las personas”? ¿Qué relación hay entre el agente creador y el agente creado? En este trabajo procuraré adentrarme en estas preguntas y propongo pensar la agencia de la imagen no como una mera voz activa que enuncia desde el lugar del yo soberano, sino desde el modelo de la voz media, en parte agente, en parte paciente.
El retorno del futuro: re-pensando la imagen (digital) como fuerza para lo político con Daniel Canogar
Authors: García Gómez Patricia
Published: January 2023

Este artículo trata de profundizar en los modos de experiencia y relación con el tiempo en la era del “presentismo”, una época que parece haber anunciado, de manera irreversible, el fin de la historia y de lo político. Pero si analizamos aquí las graves consecuencias de esta situación para la mirada y la imaginación contemporáneas no es para confirmar una vez más el diagnóstico de una contemporaneidad en crisis, sino para explorar los huecos de experiencia que todavía es posible abrir. Y lo hacemos junto al artista Daniel Canogar, cuya obra incluimos en la “categoría” de “abstracción política”, teorizada por la analista cultural Mieke Bal. Su obra, sostenemos, trata de repensar la tecnología digital, para muchos la causa de nuestros males, como una nueva fuerza creativa capaz interrumpir los hábitos temporales y perceptivos, una apuesta por el potencial performativo de la imagen.
Faktor-Faktor yang Mempengaruhi Kejadian Stres pada Tenaga Bantuan KKP Kelas I Soekarno-Hatta di Era Pandemi Covid-19 Tahun 2021
Authors: Prameswari Rasya Cyka , Syarif Syahrizal , Yuliana Terry , Karima Ulya Qoulan
Published: January 2023

Pekerja dapat mengalami stres, termasuk Tenaga Bantuan di Kantor Kesehatan Pelabuhan (KKP). Selama Pandemi COVID-19, tenaga bantuan KKP melakukan pengawasan terhadap COVID-19. Dengan beban kerja yang dimiliki dan rasa lelah memungkinkan tenaga bantuan mudah merasakan stress. Penelitian bertujuan mengetahui faktor-faktor yang mempengaruhi kejadian stres pada Tenaga Bantuan KKP Kelas I Soekarno-hatta. Pada penelitian ini menggunakan desain studi analitik yaitu cross-sectional. 90 Tenaga Bantuan yang bertugas di KKP Kelas I Soekarno-Hatta sejak Januari sampai Oktober 2020 merupakan populasi penelitian. 74 diantaranya merupakan sampel penelitian dengan kriteria telah bertugas lebih dari 4 minggu. Teknik purposive sampling digunakan dalam pengambilan sampel. Variabel bebas penelitian yaitu faktor internal terdiri dari umur, jenis kelamin, pendidikan, status pernikahan, lama kerja, motivasi, kelelahan, dan kondisi fisik. Sedangkan faktor eksternal terdiri dari beban kerja dan penggunaan APD. Variabel terikat yang diteliti adalah kejadian stres diukur menggunakan DASS-21. Data dikumpulkan dengan pengisian kuesioner online melalui Google Form. Analisis data dilakukan menggunakan uji regresi logistik ganda. Hasil penelitian pada 82,22% Tenaga bantuan yang memberikan respon, menunjukkan motivasi kerja (Nilai P = 0,015; OR = 7,32; 95% CI:1,46–3,56), kelelahan (Nilai P = 0,002; OR = 6,68; 95% CI: 1,95–22,88), dan beban kerja (Nilai P = 0,005; OR = 7,33; 95% CI: 1,79 – 29,95) berhubungan secara signifikan dengan kejadian stres. Adapun faktor-faktor yang mempengaruhi kejadian stres yaitu motivasi kerja, faktor kelelahan, dan faktor beban kerja. Dapat disimpulkan, ketiga faktor tersebut mempengaruhi terjadinya stres pada Tenaga Bantuan KKP Kelas I Soekarno-Hatta.
The antidepressant sertraline provides a novel host directed therapy module for augmenting TB therapy
Authors: Shankaran Deepthi , Singh Anjali , Dawa Stanzin , Arumugam Prabhakar , Gandotra Sheetal , Rao Vivek
Published: January 2023

A prolonged therapy, primarily responsible for development of drug resistance by Mycobacterium tuberculosis (Mtb), obligates any new TB regimen to not only reduce treatment duration but also escape pathogen resistance mechanisms. With the aim of harnessing the host response in providing support to existing regimens, we used sertraline (SRT) to stunt the pro-pathogenic type I IFN response of macrophages to infection. While SRT alone could only arrest bacterial growth, it effectively escalated the bactericidal activities of Isoniazid (H) and Rifampicin (R) in macrophages. This strengthening of antibiotic potencies by SRT was more evident in conditions of ineffective control by these frontline TB drug, against tolerant strains or dormant Mtb. SRT, could significantly combine with standard TB drugs to enhance early pathogen clearance from tissues of mice infected with either drug sensitive/tolerant strains of Mtb. Further, we demonstrate an enhanced protection in acute TB infection of the highly susceptible C3HeB/FeJ mice with the combination therapy signifying the use of SRT as a potent adjunct to standard TB therapeutic regimens against bacterial populations of diverse physiology. This study advocates a novel host directed adjunct therapy regimen for TB with a clinically approved antidepressant to achieve quicker and greater control of infection.
Positional Comparison of Jump Performance in NCAA Division I Female Volleyball Athletes
Authors: E Rush Megan , Littlefield Thomas , K McInnis Ayden , Donahue Paul T.
Published: January 2023

Background: The vertical jump task is a critical component of success in volleyball. Each position on the court has its own physical demands and has differing levels of vertical jump task demands. Objective: Thus, the objective of this investigation was to compare vertical jump performance between the two positional groups using the countermovement jump (CMJ) and squat jump (SJ). Methods: Using an observational cross-sectional study design, nineteen NCAA Division I female volleyball athletes participated in this investigation. Participants first performed three CMJ trials followed by 3 SJ trials on a force platform. Jump height, peak and mean net propulsive forces, and time to take off were calculated for both the CMJ and SJ. Reactive strength index modified and propulsive duration were additionally calculated for the CMJ and average RFD for the SJ. Independent sample t-tests were performed comparing positional groups on each variable of interest with Hedges g effect sizes additionally calculated. Results: No statistically significant differences (p 0.05) were found between any of the variables of interest in the CMJ though moderate effect sizes were seen in jump height (g =0.78). No statistically significant differences were present in the SJ though moderate effect sizes were seen in RFD (g = 0.65), mean propulsive force (g = 0.79) and peak propulsive force (g = 0.66). Discussion: As the vertical jump task is a critical task for high-level performance in both positions, and the no differences seen between groups, training programs should be designed to improve jump performance with special attention to the individual athletes’ needs rather than the specifics of the playing position.
Effects of high-intensity interval exercise on cardiac troponin elevation when comparing with moderate-intensity continuous exercise: a systematic review and meta-analysis
Authors: Li Shuoqi , Shaharudin Shazlin , Cirer-Sastre Rafel , Li Feifei , Abdul Manaf Faizal , Mohd Shukri Mohd Faiz
Published: January 2023

Background

This systematic review and meta-analysis aimed to compare the effects of high-intensity interval exercise (HIIE) with different recovery modes versus moderate-intensity continuous exercise (MICE) on cardiac troponin (cTn) elevation.

Methodology

A literature search was conducted in four databases: Scopus, PubMed, EBSCO and Web of Science from January 2010 to June 2022. The articles were screened, evaluated for quality before data were extracted. The review protocol was registered at PROSPERO (CRD42021245649). Standardized mean differences (SMD) of peak cTn were analyzed with a 95% confidence interval (95% CI) using Revman 5.4 software.

Results

Six studies satisfied the inclusion criteria with a total of 92 and 79 participants for HIIE and MICE, respectively. Overall, there was no significant difference between HIIE and MICE in the elevation of cardiac troponin T (SMD: 0.41 [95% CI [−0.21, 1.03]], p = 0.20, I2 = 77%, p for heterogeneity <0.01). In subgroup analysis, HIIE with passive recovery elicits greater release of cardiac troponin T than MICE (SMD: 0.85 [95% CI [0.44, 1.27]], p < 0.01, I2 = 32%, p for heterogeneity = 0.22). Changes of cardiac troponin T (SMD: 0.41 [95% CI [−0.21, 1.03]], p = 0.20, I2 = 77%, p for heterogeneity < 0.01) after HIIE with active recovery were not significantly different from those of MICE.

Conclusions

There was no significant difference between HIIE and MICE in the elevation of cardiac troponin T. However, HIIE with passive recovery elicited more cardiac troponin T elevation than MICE, which should be considered when developing exercise programs.
Transcriptome and metabolome response of eggplant against Ralstonia solanacearum infection
Authors: Xiao Xi Ou , Lin Wenqiu , Feng Enyou , Ou Xiongchang
Published: January 2023

Bacterial wilt is a soil-borne disease that represents ubiquitous threat to Solanaceae crops. The whole-root transcriptomes and metabolomes of bacterial wilt-resistant eggplant were studied to understand the response of eggplant to bacterial wilt. A total of 2,896 differentially expressed genes and 63 differences in metabolites were identified after inoculation with Ralstonia solanacearum. Further analysis showed that the biosynthesis pathways for phytohormones, phenylpropanoids, and flavonoids were altered in eggplant after inoculation with R. solanacearum. The results of metabolomes also showed that phytohormones played a key role in eggplant response to bacterial wilt. Integrated analyses of the transcriptomic and metabolic datasets indicated that jasmonic acid (JA) content and gene involved in the JA signaling pathway increased in response to bacterial wilt. These findings remarkably improve our understanding of the mechanisms of induced defense response in eggplant and will provide insights intothe development of disease-resistant varieties of eggplant.
Correlation of Alcohol Dependence and Delusions of Infidelity: A Cross-sectional Study
Authors: Reddy Mrinalini , Pradeep Arun Narayan , . Vadivumbal , . Sivabalan
Published: January 2023

Introduction: Delusions of infidelity are harmful malfunctioning beliefs that can bear significant impact on an individual’s interpersonal, social and occupational functioning. The exact prevalence is not known due to the lack of community surveys but is not uncommonly seen by practicing physicians. However, they are more common in male alcoholics, morbid jealousy is encountered mostly in old age psychiatry and clinicians should be familiar with its recognition and management. Aim: To identify the correlation of delusion of infidelity in patients with alcohol dependence syndrome. Materials and Methods: A cross-sectional study was conducted at psychiatric Outpatient Department (OPD), SRM Medical College, Hospital and Research Centre, Chennai, Tamil Nadu, India, for duration of one month in March 2020. Male patients attending the Psychiatric OPD, diagnosed with alcohol dependence syndrome as per International Classification of Diseases-10 (ICD-10) guidelines were selected. A total of 30 patients who attended the OPD in one month were screened by Mini-International Neuropsychiatric Inventory (MINI). Alcohol Dependence Scale (ADS) for alcohol dependence as well as Browns Assessment of Beliefs Scale (BABS) to assess their delusion was applied. Statistical analysis using regression analysis and correlation coefficient was done. Results: The mean of age of study group was 32.47 years with a standard deviation of 5.05 years. Out of the 30 male alcoholic patients, 13 patients had delusions of infidelity. The mean alcohol dependence score of study population was 27.6±11.51 and the mean BABS of study population was 9±10.77. Conclusion: There was a weak positive correlation between alcohol dependence and the delusions of infidelity. Physicians must have sufficient knowledge in identifying alcohol dependence syndrome.
Clinical Impact of Hydrocortisone Uses on Patient with COVID-19: A Case Report
Authors: Owhonda G. C. , Nonju T. I. , Eze-Emiri C. N. , Oris-Omini V.
Published: January 2023

COVID-19 can cause anything from no symptoms at all to severe breathing problems, organ failure, and even death. Currently, there is no cure for COVID-19, thus treatment focuses on providing the patient with as much comfort as possible. Hydrocortisone are utilized for patients with acute respiratory disease syndrome and septic shock because they shorten the need for mechanical ventilation, ICU stay, and perhaps mortality. This prospective case report study showed the intravenously administered Hydrocortisone response on a patient admitted to the Elekahia COVID-19 treatment centre, located in Port Harcourt, Rivers State, Nigeria. The patient was a 47-year-old man of Asian descent; he presented with pneumonia-like symptoms and developed severe breathlessness. Treatment started on 6th June 2020 and ended on 16th June 2020. 

There was a marked improvement in peripheral capillary oxygen saturation (SpO2) after hydrocortisone intervention; respiratory rate reduced from 40 cycles per minute to 18 cycles per minute, and the patient could complete sentences without developing breathlessness, three hours after receiving the first dose of intravenous hydrocortisone.

The use of Hydrocortisone therapy could be of tremendous benefit in the treatment of COVID-19 patients who present with severe respiratory distress. Controlled randomized clinical trials are required to assess steroid use in COVID-19 treatment properly. And to assess its use as a prophylactic in the early management of severe COVID-19 cases.
Genetic Variability, Heritability and Genetic Advance for Agronomic Traits of Ethiopian Sorghum [Sorghum bicolor (L.) Moench] Landraces
Authors: Alemu Habtamu , Demelash Habtamu
Published: January 2023

Sorghum (Sorghum bicolor L. Moench) is an important food security crop mainly in semi-arid and tropical parts of the African countries. Even though it is believed to be originated and domesticated in Ethiopia, sorghum production is inhibited by limited number of high yielding varieties. A field experiment was conducted at Assosa and Pawe Agricultural Research Centers during the 2019/20 cropping season with the objective of identifying sorghum landraces and breeding lines with high grain yield, study phenotypic and genotypic variability, heritability and genetic advance for yield and yield contributing traits. Forty two (42) sorghum landraces and breeding lines were planted in RCBD design in row column arrangement with two replications. The result of analysis of variance revealed that there is a significant variation among the tested landraces and breeding lines for all the evaluated characters. The highest yield of 3297Kg/ha was recorded for AScol19-Krm 124 followed by Ya036/1 with the mean yield of 3146kg/ha while the lowest grain yield of 817kg/ha was recorded for ETSCAs 10002-2-13-1 breeding line. Higher Phenotypic Coefficient of Variation and Genotypic Coefficient of Variation values were scored for grain yield. High estimates of broad sense heritability were found in all plant characters under study. Highest heritability estimates (97.8) were found in grain yield. Values of genetic advance ranged between 21.94 for days to physiological maturity to 1934.46 for grain yield and the genetic gain (of the mean percent) was ranged from 11.48 for days to physiological maturity to 99.41 for grain yield. The greater extent of broad sense heritability together with higher genetic advance in characters studied showed the evidence that these traits were under the control of additive genetic effects which means undertaking selection in these landraces and breeding lines should lead to a rapid enhancement of the traits studied.
Functional and Hemodynamic Efficacy of Non-Poliferative Diabetic Retinopathy Treatment by Endonasal Electrophoresis of Tanakan
Authors: Kangilbaeva Guzal , Bakhritdinova Fazilat , Oralov Behruz , Jurabekova Aziza
Published: January 2023

Aims: To study the effectiveness of the treatment of patients with non-proliferative diabetic retinopathy by tanakan endonasal electrophoresis according to functional and hemodynamic data.

Study Design: Cross-sectional comparative analysis.

Place and Duration of Study: Department of Ophthalmology, clinic of Tashkent Medical Academy, between 2017 and 2020.

Methodology: We included 66 patients (123 eyes), 23 men and 43 women; age range 18-75 years with non-proliferative diabetic retinopathy. The patients were divided into 2 groups: to receive daily tablets of Tanakan (control), or daily endonasal electrophoresis of Tanakan (main) within ten days. Before and after the course of therapy, the patients underwent determination of visual acuity, Doppler ultrasound imaging of the eye and computer static perimetry.

Results: Improvements in visual acuity were observed in 87,3%  of the main group patients, and in 22% of the control group. Statistically significant increase in blood flow velocity and a decrease in the resistance index were observed in the main group (P < 0.05). Retinal photosensitivity increased by 22% in the main group, and by 10% in the control group. The mean deviation from the age norm decreased by 33% in the main group and by 12% in the control group. Among the patients of the main group, 30% experienced a decrease in absolute scotomas and 100% in relative scotomas. Among the patients of the control group, 21% and 83% experienced a decrease in absolute and relative scotomas, respectively.

Conclusion: Treatment with tanakan endonasal electrophoresis significantly improved visual acuity, eye hemodynamics, and retinal photosensitivity. This treatment is more effective than the traditional use of ginkgo- biloba tablets.