bluuebunny/crossref_metadata_2025 huggingface dataset:
DIAGNOSTIC EFFICACY OF CONE BEAM COMPUTED TOMOGRAPHY (CBCT) IN CHRONIC PERIODONTITIS - A SYSTEMATIC REVIEW AND META ANALYSIS
Authors: Pagare Nimisha , Gujar Dnyaneshwari , Gopalakrishnan Dharmarajan
Published: February 2025

Aim: To evaluate better diagnostic efficacy between cone beam computed tomography (CBCT) and other conventional imaging techniques for periodontal parameters in chronic periodontitis (CP)

Methods: Review adhered to with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines and registered in PROSPERO- CRDXXXX. Databases were searched from January 2000 to May 2024 for studies evaluating the diagnostic efficacy or accuracy of CBCT compared to conventional radiographic techniques and evaluating outcome in terms of periodontal parameters like furcation width, horizontal bone loss, vertical bone loss and bone defects. Quality assessment was evaluated using Cochrane risk of bias (ROB) -2 tool for randomized controlled trials (RCTs) through its domains using Review manager (RevMan) software version 5.3.

Results: Eight studies were included in qualitative synthesis and four studies for meta-analysis. Quality assessment revealed a moderate to low risk of bias. The results of meta-analysis, showed that for furcation width -0.59 (-1.87 - 0.69), horizontal bone loss 1.56 (-2.11 - 5.24), vertical bone loss 1.62 (-1.94 - 5.19) and bone defects -0.78 (-2.19 - 0.64) were detected better by CBCT imaging. Also, funnel plot did not show any asymmetry indicating absence of possible publication bias in meta-analysis.

Conclusion: CBCT overall was more accurate and provided more quantitative data with greater precision and lesser deviations compared to conventional imaging techniques in chronic periodontitis. However, furthermore studies showed be conducted with robust methodology with proper standardization protocols to validate the study findings.

Clinical Significance: The study highlights the clinical significance of CBCT in diagnosing chronic periodontitis, emphasizing its superior accuracy, precision, and three-dimensional imaging capabilities compared to conventional radiographs. These advantages are critical for accurately detecting periodontal defects, guiding treatment decisions, and improving outcomes in complex cases. The study also calls for further research with standardized protocols to validate these findings and support CBCTs broader clinical application.
POST-CAUDAL BLOCK PRIAPISMIN CHILDREN: ARARE COMPLICATION NOT TO BEUNDERESTIMATED
Authors:   Anesthesiology Department, Mohammed 5 Military Hospital of Rabat, Morocco., Hamza Kassimi , Larbi Ed-dafali ,   Anaesthesiology Department, Children Hospital of Rabat, Morocco., Koraichi Alae El ,   Anaesthesiology Department, Children Hospital of Rabat, Morocco., Cherif El Kettani Salma Ech ,   Anaesthesiology Department, Children Hospital of Rabat, Morocco., Mustapha Bensghir ,   Anesthesiology Department, Mohammed 5 Military Hospital of Rabat, Morocco., Aziza Bentalha ,   Anaesthesiology Department, Children Hospital of Rabat, Morocco.
Published: February 2025

Caudal anesthesia, commonly used in pediatric sub-umbilical surgeries, is well-regarded for its safety and simplicity. However, rare complications such as priapism may occur. We report the case of a 4-year-old child undergoing inguinal hernia repair who developed pulsatile priapism following a caudal block with bupivacaine. The complication was managed through deepening of anesthesia and symptomatic measures, with spontaneous resolution after 5 hours and no long-term sequelae. This case highlights a potential reflexogenic mechanism involving parasympathetic hyperactivity due to sympathetic fiber blockade. Although rare, post-caudal block priapism requires heightened vigilance and prompt management to prevent serious complications.
Investment behavior in the Egyptian stock market: The impact of social media on investor decision-making
Authors: Awad Abdelrehim , Fathy Aziz Adel , Rashad Shma Talaat
Published: February 2025

Social media significantly influences investor behavior, particularly in emerging markets like the Egyptian stock market. This study examines its impact on trading frequency, herding behavior, and overconfidence among Egyptian investors. Data were collected through a structured survey of 300 active investors, distributed via two prominent Facebook pages: “The Popular Union of Investors in the Egyptian Stock Market” and “Investment in the Egyptian Stock Market.” The sample was determined using Cochran’s formula for large, undefined populations, achieving a 78% response rate from the 385 recommended respondents. A descriptive quantitative approach was employed, utilizing correlation tests and regression analysis to assess relationships between social media engagement and investor behavior.Findings indicate that social media usage significantly increases trading frequency, as investors make more reactive decisions based on rapidly available information. Herding behavior is also positively associated with social media engagement, demonstrating that investors tend to follow market trends and decisions discussed in online communities. Additionally, social media exposure fosters overconfidence, leading to increased risk-taking behavior. These insights highlight the critical role of social media in shaping investor behavior, with practical implications for regulators, financial advisors, and individual investors. Regulators should promote investor education on the cognitive biases linked to social media engagement, while financial advisors must address its influence on client decision-making. Future research should explore platform-specific features, such as visual content and influencer-driven financial advice, to better understand their effects on investment strategies.
AcknowledgmentThe authors are thankful to the Deanship of Graduate Studies and Scientific Research at University of Bisha for supporting this work through the Fast-Track Research Support Program.
The role of universities’ social responsibility in enhancing business sustainability: Mediating role of entrepreneurial culture
Authors: Awad Abdelrehim
Published: February 2025

This study aims to analyze the role of sustainable social responsibility in enhancing business sustainability, with entrepreneurial culture serving as a mediating variable. Focusing on Bisha University in Saudi Arabia, it demonstrates how the university’s socially responsible practices foster an entrepreneurial culture that, in turn, drives sustainable business outcomes within the local community. A descriptive-analytical approach was adopted, with data collected through a structured survey distributed to 200 faculty members of University of Bisha, yielding 190 valid responses. Hypotheses were tested using simple linear regression and path analysis to explore both direct and indirect relationships among the study variables.The findings reveal that sustainable social responsibility significantly impacts business sustainability, explaining 49.1% of its variability. Additionally, entrepreneurial culture mediates this relationship, contributing an indirect effect of 0.446 and amplifying the total impact of social responsibility on business sustainability to 70.1%. Sustainable social responsibility also explains 46.5% of the variability in entrepreneurial culture. Model fit indices confirm the robustness of the relationships, with strong statistical significance across all paths. These results underscore the strategic importance of universities in integrating social responsibility into their operations to foster entrepreneurial culture and achieve sustainable outcomes. This study provides valuable insights for higher education institutions aiming to align their academic and operational practices with sustainability goals, contributing to broader initiatives like Saudi Vision 2030.
Acknowledgments The Deanship of Graduate Studies and Scientific Research at University of Bisha is acknowledged for supporting this work through the Fast-Track Research Support Program.
Factors Determining Investor Acceptance Towards Islamic Finance in India
Authors: Irfan Mohammad , Chowdhury Shah Saeed Hassan , Rusmita Sylva Alif
Published: February 2025

Despite India, having the second largest Muslim population in the world, Islamic finance is in its nascent stage. Thus, it is important from the perspective of the investor to understand the concept of Islamic Finance. This study scrutinizes the factors affecting the acceptance of Islamic Finance in India. A questionnaire was distributed to collect data from 354 investors from cities across India with snowball sampling. The results of the study reveal the high degree of reliability and validity of the data as reflected by Cronbach’s Alfa (α) at 0.86. Kaiser-Mayer-Olkin Measure of Sampling Adequacy (KMO) is .776, which is statistically significant. Factor analysis extracted highly loaded (Eigen value > 1) consisting of six factors with 29 items. Together these six factors explained a total variance of 76.24%. These factors are Awareness of Shariah indices, Religious motive, Social responsiveness, Understanding of Shariah screening, Ethical investment, and Socio-economic reasons.
Developing Sustainable Hajj Funds: Innovative Cash Waqf Investment Models
Authors: Fuadi Nasrul Fahmi Zaki , Farida Dessy Noor , Saadah Naili , Ramadhani Cintya Cindy Melania , Imron Ali
Published: February 2025

The Indonesian Sharia Economic Masterplan (MEKSI) 2019-2024 presents a detailed plan for the growth of the Islamic financial industry. It focuses on combining the fiscal, commercial, and ZISWAF (Zakat, Infaq, Sadaqah, and Waqf) sectors to promote economic inclusivity. The objective of this study is to assess the management mechanism of the Hajj Fund by BPKH and investigate alternative investment models that make use of cash waqf to enhance the efficiency of fund management. The technique encompasses an extensive examination of existing literature, both qualitative and quantitative evaluations, interviews with relevant stakeholders, and a comparative analysis of successful models implemented in other countries. Financial modeling is utilized to simulate the effects of various asset allocation methods. The results suggest that integrating cash waqf into BPKH's current procedures can lead to considerable improvements. Cash waqf offers higher financial returns and larger social welfare benefits through targeted investments in Sharia-compliant financial instruments such as Sukuk. The iterative process of allocating and reinvesting income guarantees the long-term viability and expansion of Hajj funds. The study highlights the capacity of cash waqf to strengthen financial stability and social influence, in accordance with Islamic principles and promoting economic growth. These findings have significant ramifications for politicians and financial managers in enhancing the management of Hajj funds to more effectively cater to the needs of the Muslim community.
Assessing the restoration criteria for an urban ‘canal daylighting’: the context of Begunbari Canal, Dhaka, Bangladesh
Authors: Fatemi Md. Nawrose , Rahman Tahmina , Shawpnil S. M. Ehsan Ul Haque , Ahmed Iftekhar Uddin
Published: February 2025

Due to the rapid urbanization and expansion of cities, many urban waters, such as canals and streams, have disappeared from the surface in metropolitan areas like Dhaka. Identifying the potential socioeconomic and ecological value of these long-lost urban waters, particularly to ensure urban resilience, efforts to restore these streams are being emphasized as a prevalent practice in green-blue infrastructure design. The Begunbari Canal was strategically interconnected to the eastern fringe, central, and western parts of Dhaka and served as a crucial outlet for drainage and stormwater, making it geographically and environmentally vital for the city. This study intends to restore the Begunbari Canal of Central Dhaka by de-culverting it and to assess the restoration criteria for this particular ‘canal daylighting’ initiative. It has been conducted as a mixed-method research approach through historical and contextual analysis, map regression, thematic analysis, experts' opinions, transect walks, and photographic documentation to explore the criteria and possibilities for resurfacing the Begunbari Canal. Findings reveal the possibilities of resurrecting the forgotten presence of this buried canal, indicating a set of guidelines for its resurfacing. These insights will benefit policymakers, urban planners, urban designers, and local citizens to regenerate a green-blue network for interconnectivity and communication.
Multi-tiered strategy for large-scale wastewater detection of SARS-CoV-2 in low-case settings provides confidence for public health actions
Authors: Jex Aaron , John Nijoy , McCarthy David , Myers Steven , Begue Natacha , Schang Christelle , Usher Shane P. , Baker Louise , Kaucner Christine , Monis Paul , Hartman Leon M. , Flynn Brianna , Merrett James E. , Lister David , Herold Marco , Kueh Andrew , Cheng Ngai Ning , Nolan Jackson , Caly Leon , Druce Julian , Thorley Bruce , Scales Peter J. , Schmidt Jonathan , Sarkis Suzie , Crosbie Nicholas D. , Poon Rachael , Nolan Monica
Published: February 2025

Wastewater surveillance has played a pivotal role in monitoring SARS-CoV-2 transmission worldwide. However, developing and implementing the methods underpinning these programmes in regions with prolonged periods of low community transmission has proven challenging. In Victoria, Australia, wastewater surveillance provided early warning of unknown community infections and informed timely public health decisions to limit their spread when case numbers were low. To achieve this, we developed a methodological approach sensitive to extremely low viral loads and could readily identify false positives within short turnaround times. Here, we describe the successful development, implementation, and evaluation of analytic methods using Reverse Transcriptase Quantitative Polymerase Chain Reaction (RT-qPCR) and amplicon sequencing in tandem with CRISPR DETECTR in an ongoing, large-scale surveillance programme to detect SARS-CoV-2 in wastewater in Victoria, Australia. Our study covers ten months, from July 2020 to April 2021, and includes all state-wide health districts and prolonged periods with no known, active community cases among the ∼6.7 million population.
Z-scheme heterojunction BiOBr/MIL-100(Fe) visible photocatalytic-permonosulfate degradation of AO7
Authors: Liu Xin , Cheng Xianxiong , Lian Junfeng , Tang Jiahua , Wang Rui
Published: February 2025

Metal–organic frameworks (MOFs) have garnered significant interest in the field of photocatalysis. In this study, Z-scheme heterojunction BM-x composites consisting of bismuth bromide oxide (BiOBr) and iron-based metal–organic backbone (MIL-100(Fe)) were successfully synthesized using ethylene glycol as a solvent. The composites were characterized using various techniques. BM-x exhibit abundant functional groups, large specific surface areas, and narrow band gap energy, thus provide numerous active sites for catalytic reactions and respond well to visible light. Notably, BM-7 displays remarkable catalytic activity in a visible light-activated permonosulfate (PMS) system and achieves a degradation rate of 99.02% over 100 mg/L gold orange II (AO7) within 60 min. The effects of BM-7 and PMS addition, initial AO7 concentration, initial pH, inorganic anions, and humic acid on the degradation system were investigated. The proposed mechanism of the Z-scheme heterojunction in the BM-7 photocatalyst demonstrates effective photoelectron transfer from the BiOBr conduction band to the MIL-100(Fe) valence band, resulting in excellent catalytic activity. Radical burst experiments identified 1O2, h+, and ·O2− as the main active substances. BM-7 has high stability and reusability, with a degradation rate reduction of only 14.48% after three recycles. These findings provide valuable insights into using persulfate combined with visible light.
Experiencias educativas interculturales en el Caribe colombiano
Authors: Angarita Ossa Jhon Jairo , Sánchez Fontalvo Iván Manuel , Angarita Ossa Jhon Jairo , Macias Lara Liliam María , Muelas Izquierdo Dunen Kaneybia , Pimienta Semprun Saren Leonor , Pitalúa Pantoja Luis Carlos
Published: February 2025

Experiencias educativas desde la interculturalidad en el Caribe colombiano es la compilación de cinco investigaciones en proceso que dan cuenta de territorios locales y el protagonismo de las comunidades escolares, indígenas y afrodescendientes en ellos. Además, resaltan el reconocimiento de los sujetos a partir de encuentros dialógicos y otras herramientas metodológicas que abordan temáticas como el patrimonio cultural inmaterial afrodescendiente en clave de saberes propios; la medicina tradicional ette ennaka en diálogo con la medicina occidental; el papel de las mujeres indígenas arhuacas frente a la educación propia; la interculturalidad en el sistema educativo y su influencia en la praxis educativa con comunidades wayuu; y, por último, la identidad y su relación con la calidad educativa en contextos multiculturales. Estos potentes campos en desarrollo proponen argumentos y atisbos que, sin ser concluyentes, dejan abierta la puerta para pensar la interculturalidad en el Caribe colombiano.
DROGA KOŚCIOŁA W STANACH ZJEDNOCZONYCH DO PEŁNEGO UCZESTNICTWA W EUCHARYSTII – WYZWANIA, RZECZYWISTOŚĆ, PERSPEKTYWY
Authors: Powroźnik Tomasz
Published: February 2025

Artykuł omawia inicjatywę Narodowego Odrodzenia Eucharystycznego w USA (2022–2025), będącą odpowiedzią Kościoła katolickiego na spadek wiary w rzeczywistą obecnośćChrystusa w Eucharystii. Głównym elementem inicjatywy był Narodowy KongresEucharystyczny w Indianapolis, który, wraz z licznymi wydarzeniami parafialnymi i rekolekcjami,miał na celu pogłębienie zrozumienia i przeżywania tajemnicy Eucharystii.Badania pokazują niedostateczną wiedzę wielu katolików na temat Eucharystii. Badaniapokazują niedostateczną wiedzę wielu katolików na temat Eucharystii, co wymaga intensywnejedukacji. Dzięki zaangażowaniu duchowieństwa, biskupów i wiernych inicjatywaprzekształciła się w ruch odnowy duchowej, który podkreśla rolę Eucharystii jako fundamentuwspólnoty Kościoła. Jest to nie tylko odpowiedź na kryzys wiary chrześcijańskiejw USA, ale także wezwanie do globalnej odnowy wiary i świadectwa miłości Boga.
KATECHEZA MISTAGOGICZNA JAKO PRZYGOTOWANIE DALSZE DO SAKRAMENTU BIERZMOWANIA
Authors: Kurzydło Dariusz
Published: February 2025

Po przyjęciu przez dzieci pierwszej Komunii św. następuje czas pogłębienia tego doświadczeniawiary. Katecheza mistagogiczna, czyli wprowadzająca w doświadczenie tajemnicyzbawienia, wpisuje się w przygotowanie dalsze do przyjęcia ostatniego sakramentu wtajemniczeniachrześcijańskiego, jakim jest sakrament bierzmowania. Inaczej niż w szkole,katecheza taka – związana z formacją we wspólnocie eklezjalnej – przyjmuje obecnie nowyparadygmat, wyznaczający model towarzyszenia w rozwoju wiary. Taką wizję przedstawianajnowszy dokument wydany przez biskupów polskich, pt. Nowe drogi i kierunki formacjimłodzieży realizowane w Polsce odniesieniu do duszpasterstwa tradycyjnego. W artykuleAutor poszukuje pastoralnych, pedagogicznych i antropologicznych przesłanek pozwalającychpodjąć pracę z nastolatkiem, który wkracza w okres dorastania i potrzebuje umocnieniaw swojej drodze dojrzewania wiary.
POCZĄTKI STOWARZYSZENIA PREFEKTÓW SZKOLNYCH W KRÓLESTWIE POLSKIM (FORMY ORGANIZACYJNE)
Authors: Ceglarek Roman
Published: February 2025

W pierwszej dekadzie XX wieku, w zaborze rosyjskim, powstawało wiele towarzystw,związków i organizacji, które gromadziły przedstawicieli różnych zawodów. Wśród tychgrup znaleźli się również księża prefekci, którzy zajmowali się nauczaniem religii w szkołach.Aby podnieść swoje kwalifikacje i zwiększyć efektywność pracy katechetycznej,utworzyli organizację działającą jako sekcja Stowarzyszenia Nauczycielstwa Polskiego.Była to pierwsza tego typu organizacja w Królestwie Polskim o zasięgu krajowym, skierowanado duchownych katechetów. Pomimo tego, że działała stosunkowo krótko, w latach1906–1908, Koło Księży Prefektów miało istotne znaczenie. Zainicjowało ono działalność,która stała się fundamentem dla przyszłego stowarzyszenia księży prefektów. Po odzyskaniuniepodległości w 1918 roku, organizacja ta mogła rozwijać swoją działalność na terenie całejPolski, włączając wszystkie diecezje i pełniąc kluczową rolę w edukacji religijnej w nowoodrodzonym państwie.
PROPOZYCJA KATECHETYCZNEJ INTERPRETACJI BIBLIJNEJ DLA KATECHETÓW DZIECI I MŁODZIEŻY
Authors: Stypułkowska Beata
Published: February 2025

Niniejszy artykuł przedstawia propozycję katechetycznej interpretacji biblijnej składającej się z trzech etapów: zrozumienia wyrazowego, zrozumienia teologicznego oraz zrozumienia egzystencjalnego. Jest ona przeznaczona dla katechetów dzieci i młodzieży do zastosowania na lekcji religii oraz podczas katechezy parafialnej.
Zrozumienie wyrazowe jest etapem wyjściowym, przygotowawczym, ale koniecznym do poprawnej interpretacji tekstu biblijnego. Polega na zrozumieniu sensu wypowiedzi w jego wymiarze literackim i historycznym. Zrozumienie teologiczne jest etapem pośrednim, który koncentruje się głównie na głównym temacie teologicznym perykopy. Zrozumienie egzystencjalne jest etapem wieńczącym czytanie i rozważanie tekstu biblijnego. Istotą tego etapu jest czytanie tekstu biblijnego jako słowa Bożego, aby wprowadzić je w życie.
PEDAGOGIKA RELIGII W UJĘCIU KS. PROF. ZBIGNIEWA MARKA SJ
Authors: Zellma Anna
Published: February 2025

Pedagogika religii jest subdyscypliną wyodrębnioną w dziedzinie nauk społecznych, w ramachdyscypliny pedagogika. Posiada ona liczne punkty styczne z teologią i naukamio wychowaniu. Analizy podjęte w niniejszym artykule bazują na twórczości naukowej ks.prof. Zbigniewa Marka SJ. Zmierzają do ukazania współczesnego rozumienia pedagogikireligii w ujęciu tego Autora. W związku z tym najpierw zaprezentowano przyjęte przez niegorozumienie pedagogiki religii i jej relacji do katechetyki. Następnie analizowano podejmowaneprzez ks. prof. Z. Marka SJ kwestie dotyczące statusu metodologicznego pedagogikireligii. Doceniając wkład Autora w rozwój tej subdyscypliny naukowej, zwrócono uwagęna antropologiczno-filozoficzne podstawy pedagogiki religii oraz jej przedmiot, źródłai metody. Wskazano również na cele pedagogiki religii. Koncentrują się one wokół teoriii praktyki edukacji religijnej, wychowania religijnego, wychowania moralnego, formacjii duchowości, warunkowanych społeczno-kulturowymi czynnikami, a także otwieraniawychowanków na transcendencję i wspierania w osiąganiu dojrzałości. Cele te znajdująswoje ukonkretnienie w tworzeniu nurtów i koncepcji pedagogicznych inspirowanychreligią.
Aspectos sanitários e adaptabilidade de caprinos da raça canindé em região semiárida
Authors:   , Fonseca Elanne de Paiva
Published: February 2025

criação de ruminantes localmente adaptados, como os caprinos da raça Canindé, é uma característica de alguns sistemas de produção da região nordeste do Brasil. Nesse contexto, as parasitoses gastrintestinais e a linfadenite caseosa são responsáveis pela diminuição da população desses animais, representando uma das principais problemáticas observadas na caprinocultura. Com isso, o objetivo do presente estudo foi avaliar as condições adaptativas de cabras Canindé em relação aos aspectos fisiológicos, clínicos, hematológicos e bioquímicos durante o ano e sua resistência as endoparasitoses gastrintestinais e a linfadenite caseosa, criadas em região semiárida. Foram utilizadas 180 fêmeas da raça Canindé em região semiárida. Dentre as variáveis avaliadas estão: aspectos ambientais, fisiológicos, perfil hematológico e os valores bioquímicos séricos, peso, escore de condição corporal e o estado sanitário. As variáveis foram avaliadas em dois períodos do ano: chuvoso e seco. A dissertação é composta por três capítulos: (I) Referencial teórico, percorrendo assuntos voltados a caracterização dos sistemas produtivos do semiárido e a importância dos recursos genéticos de raças localmente adaptadas (II) Uma avaliação da termorregulação e do desempenho de cabras da raça Canindé durante o período seco e chuvoso; (III) Uma verificação da presença de endoparasitoses gastrintestinais e a relação dos valores hematológicos e bioquímicos e o diagnóstico da linfadenite caseosa. O estudo relata que houve diferença entre os períodos, mas, em contexto geral, não fugiram do preconizado para a espécie, levando em consideração as condições ambientais do semiárido. Esses resultados divergentes do preconizado para a espécie podem ser devido as características particulares da raça e sua adaptabilidade. Todos esses aspectos estudados servem como base para compreender a fisiologia e o manejo adequado dos caprinos localmente adaptados, buscando manter seus recursos genéticos.
Desenvolvimento de uma plataforma de comunicação para monitoramento das variáveis de um sistema de geração distribuída do tipo fotovoltaico através do uso de tecnologias sem fio e dispositivos planares
Authors:   , Azevêdo Pablo Lucian Cardoso de
Published: February 2025

Com o crescente aumento de usinas solares fotovoltaicas, faz se necessário meios de obtenção de variáveis correlacionados a sua capacidade de geração e meios para a transmissão desses dados obtidos. Para esse trabalho será desenvolvido uma plataforma de comunicação para obtenção, armazenamento e transmissão dos parâmetros de um sistema de geração de energia elétrica por meio da energia solar fotovoltaica, tais como níveis de radiação solar e temperatura de operação nos painéis solares da usina Mossoró II instalada na Universidade Federal Rural do Semiárido. No decorrer do trabalho será demonstrado o projeto do protótipo, que será divido em duas etapas: uma voltada para aquisição desses parâmetros e outra para o sistema de comunicação onde ocorrerá a transmissão dos dados via rádio frequência. Para esse estudo será utilizado a plataforma de prototipagem arduino, responsável pela interconexão das partes de aquisição de dados e transmissão por meio de rádio frequência. Para o envio dos dados foi adotado o transceptor NRF24L01 cujo a frequência de operação está dentro da faixa ISM 2,4 GHz, com isso foi projetada uma antena do tipo Yagi planar. Os resultados das simulações foram obtidos por meio da utilização do software ANSYS HFSS®. Os resultados das simulações atingiram as características da aplicação, pois a perda de retorno da antena apresentou conformidade com a faixa da frequência do transceptor, em relação a características de radiação a antenas teve diagrama de radiação direcional e um ganho de aproximadamente 8,71 dB. O comportamento da perda de retorno obtido por meio da medição da antena construída foi similar em valores e em seu comportamento, porém com um leve deslocamento da frequência de ressonância, que a níveis práticos não interferem para essa aplicação da antena. Após isso, a antena foi implementada no transceptor realizando teste de alcance a fim de averiguar a comunicação dos dispositivos, apresentando um resultado satisfatório, desse modo o sistema foi implementado e os parâmetros influenciadores de um sistema fotovoltaico foram adquiridos
Antimicrobial Resistance: Challenges and Innovative Solutions
Authors: Ghulam Nabi Ibtsam , Khan Madiha , Mubeen Hira
Published: February 2025

Antimicrobial Resistance (AMR) poses a critical threat to global health, contributing to increased morbidity, mortality, and substantial economic
burden. This review highlights the profound clinical and financial consequences of infections caused by multidrug-resistant (MDR) bacteria. Of
particular concern is the escalation of bacterial resistance linked to the indiscriminate use of antibiotics during the COVID-19 pandemic, which
could lead to increased mortality rates. Additionally, this article emphasizes the significance of Antimicrobial Stewardship (AMS), which is a
healthcare strategy aiming to encourage, develop, monitor, and assess the sensible use of antimicrobials in order to protect their long-term success.
Consequently, it highlights the value and effects of an Antimicrobial Stewardship Program (ASP) in combating resistance and protecting global
health.

Furthermore, the necessity of adopting a holistic “One Health” approach, an integrative, multisectoral strategy, is discussed as essential in
addressing the growing AMR crisis. The review advocates for evidence-based policies that support the “One Health” framework, enhance
immunization programs, educate healthcare professionals, and raise public awareness about AMR. This article provides a comprehensive overview
of the scale, consequences, and potential solutions to AMR, urging collaborative efforts across sectors and stringent measures to combat this global
health challenge.
An Untold Story of Ionic Liquid for the Isatin Derivative Synthesis
Authors: Sharma Shubham , Vaishali  , Pandey Aaysha , Rani Swati , Sharma Pooja , Mishra Kaushiki , Kumar Akash , Kumar Himansh , Dhyani Archana
Published: February 2025

Due of its unique features and environmental benefits, green synthesis is attracting researchers
worldwide. To expand the uses of ionic liquids (ILs) in green chemistry, particularly as environmentally friendly
solvents and catalysts, researchers are investigating novel methods to ILs and improving their characteristics.
Due to its exceptional properties, ILs have been widely utilized as a green catalyst and solvent system in the
synthesis of valuable heterocyclic compounds. Aza-heterocycle isatin derivatives are regarded for their versatility
in drug development and medicinal research. Organic chemists have developed isatin-based frameworks
employing ILs as solvents and catalysts aligning with one of the main goals of green synthesis, maximize synthetic
efficiency while reducing environmental effects. This review provides a comprehensive summarization of
reports related to the IL-assisted isatin derivative synthesis.
Study on the Mechanism of the Leaves of Dimocarpus longan Lour. in the Management of Type 2 Diabetes based on Metabolomics
Authors: Liang Jie , zheng Piaoxue , Hu Jue , Liu Xianfu , Chen Kuikui , Cao Yupin , Liang Yanli , Lu Chunlian , Xie Jingjing , Ma Yuming , Peng Jiawen , Qin Zujie
Published: February 2025

Background:

Diabetes mellitus (DM) is a chronic metabolic disease. The leaves of
Dimocarpus longan Lour. (LYY), a well-known traditional Chinese medicine (TCM) with
Guangxi national characteristics often used in simple recipes to treat DM has attracted increasing
attention. In this study, we investigated the therapeutic effects of LYY in diabetic rats from a
metabolomic perspective.

Methods:

The type 2 diabetes (T2DM) rat model was induced by a high-sugar and high-fat diet
(HSFD) combined with 40 mg/kg streptozotocin (STZ). After oral administration of LYY (10.7
g/kg) for 28 d, their weight, fasted blood glucose (FBG), blood lipid levels, and inflammatory
factors were assessed. The feces, urine, and serum samples of the rats were collected, and proton
nuclear magnetic resonance (1H-NMR) technology was used to explore the changes in the sample's
metabolism spectrum and analyze the relevant targeted metabolic pathways.

Results:

Compared with the diabetes group, LYY rats significantly delayed the reduction of body
weight and decreased the FBG level (P <0.01); the levels of total cholesterol (TC), triglycerides
(TG), and low-density lipoprotein-cholesterol (LDL-C), IL-6, and TNF-α in serum significantly reduced
(P < 0.05, 0.01), and the level of high-density lipoprotein-cholesterol (HDL-C) significantly
increased (P < 0.01). 2 candidate biomarkers were identified from feces samples, and 4 associated
metabolic pathways were discovered. 13 potential biomarkers were screened from urine samples,
leading to the identification of 16 related metabolic pathways. Similarly, 5 potential biomarkers
were screened from serum samples, and 11 related metabolic pathways were found.

Conclusion:

LYY can regulate the metabolic disorder caused by T2DM by regulating amino acid
metabolism, amino acid synthesis, and tricarboxylic acid cycle, which provides a specific reference
for the clinical treatment of T2DM.
Visualization Analysis of Tau Protein in the Brain of Alzheimer’s Disease: A Scoping Literature Review
Authors: Zhang Dan-qi , Yang Xu , Niu Han-bin , Sun Xu-chen , Cao Dan-na , Li Ang , Yue Jin-huan , Li Xiao-ling , Zhang Qin-hong
Published: February 2025

Introduction:

This study analyzed the current status, hotspots, and development trends
of tau protein research in Alzheimer’s disease (AD) and to provide a reference for future research
in this field. CiteSpace software was used to scientifically measure and visualize the relevant articles
in the field of tau protein in AD brain from the Web of Science Core Collection database
from 1991 to 2022.

Methods:

A total of 568 articles were included, with an exponential growth in the number of articles
published from 1991 to 2022, with an average of 17.8 articles per year. The United States is
the most productive country in this field, accounting for 46.83% of the total literature. The New
York State Institute for Basic Research is the most productive organization, followed by MRC
Laboratory Molecular Biology in the UK. The most influential are Kings College London, University
of California, San Francisco, and others. Iqbal K is the most productive author.

Results:

The most productive journal is the Journal of Biological Chemistry, and the journal with
the highest impact factor is Acta Neuropathologica. The journal with the highest cumulative impact
factor is Nature. The research hotspots mainly focus on the formation and degradation mechanisms
of tau protein paired helical filaments and abnormal phosphorylation, AD neurofibrillary
tangles and degenerative changes, and model research, mainly involving tau protein abnormal
phosphorylation, phosphorylation sites, dephosphorylation, aggregate helical filaments, neurofibrillary
tangles mouse models.

Conclusion:

The research frontier trends mainly focus on the study of pathological changes in tau
protein, intervention mechanisms, and the development and practice of clinical therapeutic drugs.
Review on the Phytochemistry and Pharmacological Potential of Saffron (Crocus sativus L.)
Authors: Singh Sonia , Sharma Khushi
Published: February 2025

Saffron has been used in Chinese medicine for a very long time, dating back to 1979,
when it was first brought inside of China. According to Traditional Chinese medicine, saffron has
a sweet, moderately chilly character, and it has remarkable effects on the liver and heart systems. In
addition, this spice stimulates blood circulation, removes blood stasis, reduces blood temperature,
and eradicates heat-related toxins. The herb has been used to treat a variety of conditions, including
pain, hemoptysis, asthma, phlegm, sleeplessness, depression, anxiety, and Alzheimer's disease.
Saffron has over seventy different bioactive components, the most important of which are crocin,
crocetin, and safranal. These three components are responsible for the distinctive color and flavor
of saffron. This article briefly covers the phytochemistry and pharmacological potential of this
uncommon herb.
Artificial Intelligence in the Heart of Medicine: Transforming Arrhythmia Care with Intelligent Systems
Authors: Hamad Adel Khalifa Sultan , Haji Jassim
Published: February 2025

Background:

At a critical juncture in the ongoing fight against cardiovascular disease
(CVD), healthcare professionals are striving for more informed and expedited decisionmaking.
Artificial Intelligence (AI) promises to be a guiding light in this endeavor. The diagnosis
of coronary artery disease has now become non-invasive and convenient, while wearable
devices excel at promptly detecting life-threatening arrhythmias and treatments for heart failure.

Objective:

This study aimed to highlight the applications of AI in cardiology with a particular
focus on arrhythmias and its potential impact on healthcare for all through careful implementation
and constant research efforts.

Methods:

An extensive search strategy was implemented. The search was conducted in renowned
electronic medical databases, including Medline, PubMed, Cochrane Library, and
Google Scholar. Artificial Intelligence, cardiovascular diseases, arrhythmias, machine learning,
and convolutional neural networks in cardiology were used as keywords for the search strategy.

Results:

A total of 6876 records were retrieved from different electronic databases. Duplicates
(N = 1356) were removed, resulting in 5520 records for screening. Based on predefined inclusion
and exclusion criteria, 4683 articles were excluded. Following the full-text screening of the
remaining 837 articles, a further 637 were excluded. Ultimately, 200 studies were included in
this review.

Conclusion:

AI represents not just a development but a cutting-edge force propelling the next
evolution of cardiology. With its capacity to make precise predictions, facilitate non-invasive
diagnosis, and personalize therapies, AI holds the potential to save lives and enhance healthcare
quality on a global scale.
Design, Synthesis, and Molecular Docking Studies of Indolo[3,2-c]Quinolines as Topoisomerase Inhibitors
Authors: Badr Mohamed , Elmongy Elshaymaa I. , Sayed Ibrahim El Tantawy El , Moemen Yasmine S. , Khalil Ashraf , Elkhateeb Doaa , Binsuwaidan Reem , Ali Hadeer
Published: February 2025

Background:

The tetracyclic indoloquinoline ring system has attracted considerable interest in the
recent past due to its broad spectrum of biological activities and its binding to various types of nucleic acids.

Objective:

This study aims to elucidate their interactions with DNA and their effects on topoisomerases (TOPO) I
and II.

Methods:

Several compounds derived from 6-amino-11H-indolo[3,2-c]quinoline with diverse groups on the
quinoline ring have been successfully synthesized according to a previously established protocol where all the
synthesized indolo[3,2-c]quinoline derivatives were evaluated in vitro against A549, HCT-116, BALB/3T3, and
MV4-11 cell lines using MTT (3-[4,5- dimethylthiazol-2-yl]-2,5-diphenyl- tetrazolium bromide) assay. These
derivatives were then screened for their topo I and II inhibitory activities.

Results:

The tested compounds were more effective at killing MV4-11 leukemia cells than the standard cancer
drug cisplatin, as shown by the fact that their IC50 values were less than 0.9 μM. On the other hand, cisplatin
revealed an IC50 value of 2.36 μM. Moreover, they exhibited inhibitory activity against both Topoisomerase
(Topo) I and II. The most potent compound, 5g, demonstrated a suppressive impact on topoisomerase I, with an
IC50 value of 2.9 μM compared to the positive control Camptothecin (IC50 1.64 μM) and compound 8 displayed
remarkable topoisomerase II inhibitory activity with an IC50 of 6.82 μM compared to the positive control Doxorubicin
(IC50 6.49 μM). The cell cycle study for compounds 5g and 8 revealed that cell cycle arrest occurred at the
G1/S and S phases, respectively. Compounds 5g and 8 showed a high selectivity index, which suggests that they
could be used to develop low-toxicity chemotherapeutic agents.

Conclusion:

The results of this study demonstrate that compounds 5g and 8 can be considered promising candidates
for further anti-cancer drug development, which might be related to inhibiting TOPO I and TOPO II activities.
Variation in Rates of Neonatal Opioid Withdrawal Syndrome and Opioid-related Hospitalizations in New York State, 2018
Authors: Goldberg Benjamin , Hahn Phillip D. , Ozonoff Al , Milliren Carly E.
Published: February 2025

Background and Objective

Rates of neonatal opioid withdrawal syndrome (NOWS) among infants and opioid-related hospitalizations among adults have increased in recent decades. We examined rates of NOWS births and opioid-related hospitalizations among adult females of childbearing age overall and by sociodemographic and geographic factors using hospitalization data.

Methods

We used data from the New York State Inpatient Database for 2018 from the Healthcare Cost and Utilization Project. We identified infants with NOWS and opioid-related hospitalizations using diagnosis codes and calculated rates of NOWS per 1,000 live births and opioid-related hospitalizations per 1,000 hospitalizations among females of childbearing age. We compared rates by geographic and sociodemographic factors and examined the correlation between county-level rates.

Results

The NOWS rate was 4.66 per 1,000 live births, while the rate of opioid-related hospitalizations was 36.6 per 1,000 hospitalizations. There was variation by county and sociodemographic factors including urban-rural classification, race and ethnicity, insurance payer, and median income. We found the highest rates for both NOWS and opioid-related hospitalizations in non-metropolitan areas, among patients with public insurance, and among non-Hispanic White or Native American populations. There was a significant linear correlation (r=0.28; p=0.03) between county-level rates; however, only 32% of counties were concordant in quartiles for both measures.

Conclusion

Our findings indicate variation in rates of NOWS and opioid-related hospitalizations by geographic and sociodemographic factors, with only moderate concordance in county-level rates. These findings may provide a nuanced interpretation by examining measures impacting both women and infants and have important implications in prioritizing treatment access.
Evaluation of Health Awareness and Perceived Health Status among Men in Limpopo Province, South Africa
Authors: Chavalala Lazarros , Makhado Lufuno , Lebese Rachel Tsakani
Published: February 2025

Background

Men's health has emerged as an important public health concern requiring new healthcare interventions and increased resources. Knowledge about one’s own health influences engagement in preventive behaviours including health-seeking behaviour in men.

Objective

This study assessed health awareness and perceived health status among men in the Limpopo Province of South Africa.

Methods

A quantitative cross-sectional design was used to administer a self-administered questionnaire on 387 men conveniently available in randomly selected communities. The data were analysed using a Statistical Package for Social Science (SPSS) version 29.0. for windows. Descriptive statistics and inferential statistics were used. The significance level was set at 0.05, and all tests were two-tailed. Ethical approval was granted by the University of Venda Research ethics committee with reference number FHS/21/PH/26/1215, and permission was also obtained from community leaders.

Results

The majority (68%) of men knew that smoking poses a risk of developing lung cancer, and more than half (51%) knew it was not normal to experience pain when urinating. Health care workers were the main source of health formation, with about 75% of men receiving health care from these practitioners. More than half (54%) of men perceived their health status to be in good condition six (6) months before the study.

Conclusion

However, they lacked knowledge that too much alcohol was harmful to their health. The majority of men received health information from healthcare workers and perceived their health status to be in good condition six months before the study. There is a need for education about the impact of too much intake of alcohol on health.
The Clinical Spectrum of Aspergillus Associated Infection in Humans: A Diagnostic and Management Approach
Authors: Choudhary Pooja , Chhillar Anil K.
Published: February 2025

Aspergillus is an opportunistic fungus and most common mould, both cosmopolitan and ubiquitous in nature, that causes life-threatening invasive aspergillosis and other grave infections, which pose a precise risk to patients with compromised immune systems. Despite improved therapeutic and diagnostic approaches, invasive aspergillosis remains a cata-strophic fungal infection, such as COVID-19-associated pulmonary aspergillosis and influ-enza-associated pulmonary aspergillosis had a high prevalence in critically ill patients. It in-fects approximately ten million people each year, with a significantly high mortality rate. It is frequently convoluted COVID-19 and severe influenza disease by continuously challeng-ing diagnostic and therapeutic strategies and concomitant with significant morbidity and mor-tality rates. However, Azole-resistant Aspergillus strains are rapidly emerging and creating a significant challenge in managing Aspergillus-associated infections. Promising new antifun-gal agents, including Olorofim, Fosmanogepix, Ibrexafungerp, Opelconazole, and Rezafun-gin, are currently in clinical and preclinical trials. Treating conditions such as invasive asper-gillosis, infections caused by resistant species, and those complicated by drug-drug interac-tions remains particularly difficult in clinical practice, highlighting the urgent need for alter-native therapeutic strategies. In this review article, we highlight the characteristics and habi-tats of Aspergillus species, their pathogenicity, and the clinical challenges they pose, includ-ing diagnostic complexities. It also highlights existing and emerging therapeutic approaches for managing Aspergillus-associated infections. By integrating insights into the biology, di-agnosis, and treatment of these infections, the review emphasizes the importance of innova-tive strategies to overcome current obstacles in clinical management.
The Relationship Between Inflammatory Bowel Disease Activity and Sleep Efficiency in Adult Patients: A Systematic Review
Authors: Salem Joseph , Khan Inayat , Cooney Joseph , Yemparala Swarna , Pollok Richard
Published: February 2025

Background and Objectives:

Patients with Inflammatory Bowel Disease frequently report
disturbances in sleep. Few studies have utilized objective investigations like wrist actigraphy
or polysomnography to explore sleep patterns in patients with IBD. To address this, we conducted a
systematic review and meta-analysis to determine how disease activity impacts sleep efficiency
among IBD patients.

Methods:

We conducted a search of Medline, the Cochrane Library, the National Library of Medicine
Clinical Trial Database, and EMBASE for relevant studies from the date of establishment to
July 2023. Sleep efficiency data in active and quiescent Crohn’s disease was summarised using a
fixed-effects model.

Results:

Of the 780 articles identified in the initial search, 7 eligible studies were selected. Separate
data regarding UC was lacking. There were 5 suitable studies eligible for meta-analysis, comprising
219 participants (107 and 112 patients with active and quiescent Crohn’s Disease, respectively). In
this meta-analysis, the 95% CI of four out of five studies included unity, but the pooled analysis
revealed greater sleep efficiency in those with remission Crohn’s disease in comparison to active
Crohn’s (pooled mean difference [MD], -3.64; 95% Confidence Interval [CI], -5.56, -1.73, p=
0.0002). The degree of heterogeneity between studies was minimal (I2 = 0%, p = 0.59).

Conclusion:

We have demonstrated that worse sleep efficiency is associated with active CD compared
to quiescent disease, but there is insufficient data regarding UC. Additional research, applying
objective measures to evaluate sleep efficiency is necessary for a better understanding of the relationship
between sleep quality and disease activity in IBD.