bluuebunny/crossref_metadata_2025 huggingface dataset:
EQUIDADE NA EDUCAÇÃO E ESTUDANTES EM SITUAÇÃO DE REFÚGIO:
Authors: Franco Rocha Priscilla , Da Silva Rêses Erlando , Sant’ana Cardoso Lara Andréia
Published: February 2024

Resumo: Este artigo busca analisar a intricada relação entre a educação pública universal e os estudantes em situação de refúgio, seguindo uma estrutura dividida em duas partes distintas. Na primeira seção, após a introdução, exploramos a evolução histórica da educação pública universal, desde suas raízes antigas até sua consagração como direito humano na Declaração Universal dos Direitos Humanos em 1948. Nossa intenção nesta etapa é contextualizar o desenvolvimento desse conceito ao longo do tempo, explorando influências filosóficas, especialmente aquelas do Iluminismo. Por meio de uma abordagem histórica, identificamos marcos fundamentais que moldaram a percepção contemporânea do acesso equitativo ao conhecimento. Na segunda parte, adotamos uma abordagem metodológica reflexiva que contempla desafios inerentes à concretização da universalização da educação pública, com enfoque nos estudantes em situação de refúgio. Analisamos barreiras sociais, culturais e burocráticas que podem restringir o acesso equânime, bem como a experiência desses estudantes diante de obstáculos como barreiras linguísticas e adaptação cultural. Nossa intenção é refletir sobre as implicações desses desafios e considerar a relevância de políticas educacionais inclusivas. Ao explorar a história da educação pública universal e analisar as complexidades enfrentadas pelos estudantes em situação de refúgio, este artigo busca oferecer uma compreensão holística da interação entre teoria e prática, contribuindo para um debate consciente sobre esta temática premente.
Students’ views of historical significance – a narrative literature review
Authors: Åhsberg Cathrine Sjölund
Published: February 2024

This narrative literature review describes and critically discusses 21 years of international research addressing students’ views of historical significance. The data consist of 32 educational research articles published between 2000 and 2021. The review shows that the research area has been slowly expanding since the beginning of the millennium in regard to the number of articles and geographical representation, as well as methodological and theoretical plurality. The review identifies some representational imbalances and power gaps in this research area. Most studies represent North America and Western Europe. LGBTQ+, environmental and class-related perspectives are not found in the research. The analysis shows that students primarily identify historical substantive knowledge as significant if it is connected to official narratives. The content of these narratives is also seldom challenged. Students’ interest in the ‘darker pages’ of history, in vernacular history and in history in other places could be interpreted as providing ways to challenge these traditional narratives. Almost all researchers conclude that it is important for history education to include students’ different identities as perspectives, and to take a more disciplinary and critical approach. According to the reviewed research, this could open the way for a history education that is more relevant for students, and that meets at least some of the future challenges of a more globalised and diverse history classroom.
ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans
Authors: Kollárová J. , Kostrouchová Marta , Benda A. , Kostrouchová Markéta
Published: February 2024

ALKB-8 is a 2-oxoglutarate-dependent dioxygenase homologous to bacterial AlkB, which oxidatively demethylates DNA substrates. The mammalian AlkB family contains AlkB homologues denominated ALKBH1 to 8 and FTO. The C. elegans genome includes five AlkB-related genes, homologues of ALKBH1, 4, 6, 7, and 8, but lacks homologues of ALKBH2, 3, and 5 and FTO. ALKBH8 orthologues differ from other AlkB family members by possessing an additional methyltransferase module and an RNA binding N-terminal module. The ALKBH8 methyltransferase domain generates the wobble nucleoside 5-methoxycarbonylmethyluridine from its precursor 5-carboxymethyluridine and its (R)- and (S)-5-methoxycarbonylhydroxymethyluridine hydroxylated forms in tRNAArgUCG and tRNAGlyUCC. The ALKBH8/ALKB-8 methyltransferase domain is highly similar to yeast TRM9, which selectively modulates translation of mRNAs enriched with AGA and GAA codons under both normal and stress conditions. In this report, we studied the role of alkb-8 in C. elegans. We show that downregulation of alkb-8 increases detection of lysosome-related organelles visualized by Nile red in vivo. Reversely, forced expression of alkb-8 strongly decreases the detection of this compartment. In addition, overexpression of alkb-8 applied in a pulse during the L1 larval stage increases the C. elegans lifespan.
First Bosnian Study of the Relationship between APOE rs7412 and rs429358 Variants and Pregnancy Loss
Authors: Adler Grażyna , Mahmutbegovic E. , Uzar I. , Adler M. A. , Mahmutbegovic N. , Valjevac A.
Published: February 2024

Due to inconsistent results of APOE variants in the survival of pregnancy we investigated the potential relationship of APOE rs7412 and rs429358 with pregnancy loss (PL) in Bosnian women. We enrolled 154 women with PL. The minimum week of miscarriage was 6, while the maximum was 28. As a control group, an equal number of mothers with at least one live-born child was included. All women were recruited from the Institution of Health Protection of Women and Motherhood in Sarajevo, Bosnia and Herzegovina. Genotyping was performed by real- time PCR at the Department of General Pharmacology and Pharmacoeconomics, Pomeranian Medical University. The prevalence of genotypes E2/E3, E2/E4, E3/E3, E3/E4, E4/E4 in the group with and without PL were: 14.3 %, 1.3 %, 70.8 %, 12.3 %, 1.3 %, and 13.6 %, 1.3 %, 70.1 %, 14.3 %, 0.7 %, respectively. The frequency of the E4/E4 genotype in women with 1–2 and 3–4 PL compared to women without PL did not differ significantly between those three groups (P value = 0.0712). The frequencies of alleles ԑ2, ԑ3, ԑ4 in the group with and without PL were: 6.8 %, 85.1 %, 8.1 % and 7.5 %, 84.1 %, 8.4 %, respectively, and did not differ significantly. We conclude that our study does not confirm rs7412 and rs429358 as a potential risk factor for PL in the studied group. To elucidate the relationship between PL and variants of the APOE gene, studies with a larger sample size and placental histomorphology and genetic diagnosis are required.
Fehlerkulturen in Organisationen: Was sie uns sagen und wie wir aus ihnen lernen können
Authors: Reaper Monika
Published: February 2024

Fehler werden immer und überall gemacht, mal mehr, mal weniger. Wenn wir aus Fehlern in unseren Bibliotheken, aber auch in anderen Einrichtungen lernen, dann können wir langfristig Arbeitsprozesse optimieren, die Service-Qualität in unseren Einrichtungen verbessern und innovativ sein. Damit erhöhen wir das Alleinstellungsmerkmal unserer Bibliothek im Wettbewerb mit digitalen Angeboten und Dienstleistungen und werden stärker als kompetenter Service-Partner von unseren Nutzern wahrgenommen. Dieser Artikel beschäftigt sich damit, wie die Fehlerkultur in Bibliotheken verbessert werden kann.
FRAMED: a framework facilitating insight problem solving
Authors: Isoda Sho , Shimizu Taro , Suzuki Tomio
Published: February 2024

Insight has been studied as an element of problem solving in the field of cognitive psychology and may play an important role in clinical reasoning. We propose a new strategy based on theories that promote insight that may help generate further diagnostic hypotheses by reviewing the interpretation of a case and an individual’s list of differential diagnoses from multiple perspectives: formation (F), re-encoding (R), analogy (A), modification (M), elaboration (E), and deliberation (D) (FRAMED). The FRAMED strategy may help clinicians overcome misinterpretations and cognitive bias by systematically reflecting on previous clinical reasoning processes from multiple perspectives.
Rethinking the Theoretical Foundation of Economics I: The Multilevel Paradigm
Authors: Wilson David Sloan , Snower Dennis J.
Published: February 2024

This article is the first of a series that offers a new paradigm for economics, the “multilevel paradigm,” using generalized Darwinism as its theoretical framework. Generalized Darwinism refers to all processes that combine the ingredients of variation, selection, and replication – not just genetic evolution – making it relevant to the cultural evolution of economic systems that are embedded in political, social, and environmental systems. We contrast the multilevel paradigm with the neoclassical paradigm and other schools of economic thought. The multilevel paradigm, like the neoclassical paradigm, provides an integrative framework for micro- and macro-economics. It also incorporates the meso level, comprising groups of various sizes, linking micro and macro. Other schools of economic thought are not fully integrative in this sense, constituting instead a form of diffuse pluralism. In the integrative framework of the multilevel paradigm, many important ideas that are currently on the periphery of economics are brought toward the core.
Digitalisierung im Gefängnis: Eine multiperspektivische Betrachtung der Ausweitung des Zugangs zu digitalen Geräten für Inhaftierte im österreichischen Straf- und Maßnahmenvollzug
Authors: Hofinger Veronika , Pflegerl Philipp
Published: February 2024

Der Strafvollzug wird international zunehmend digitalisiert. In vielen Ländern haben Strafgefangene bereits Zugang zu digitalen Geräten. Forschung zu »digital rehabilitation« zeigt die Chancen auf, die sich dadurch für die Verbesserung der Haftbedingungen und die Resozialisierung ergeben. Vor diesem Hintergrund sollen auch in Österreich Inhaftierte erweiterten Zugang zu digitalen Technologien erhalten. In Vorbereitung eines Pilotprojekts wurden 39 (zum Teil ehemalige) Inhaftierte in problemzentrierten Interviews, über 600 im Strafvollzug Beschäftigte in einer Online-Befragung und 15 Fachleute zu den Chancen und Risiken der Digitalisierung befragt. In diesem Artikel werden die Ergebnisse dieser Erhebungen präsentiert und miteinander in Beziehung gesetzt. Die Befragungen zeigen, dass in einigen Bereichen überraschend viel Einigkeit besteht; gleichzeitig unterstreichen die Ergebnisse der Personalbefragung, dass innerhalb der Justizwache ein großes Bewusstsein für die Sicherheitsrisiken der Digitalisierung besteht. Der Artikel stellt eine sozialwissenschaftliche Analyse der Bedingungen für eine sinnvolle und breit akzeptierte Ausweitung des Zugangs zu digitalen Geräten für Inhaftierte dar. Das Ziel der Resozialisierung darf dabei nicht als Legitimation für die Implementierung von digitalen Technologien verwendet werden, mit denen de facto andere Ziele, wie der Ausbau von Überwachung und Kontrolle, verfolgt werden. Bedenken und Widerstände eines Teils des Personals müssen zwar berücksichtigt werden, sollten jedoch nicht dazu führen, dass Inhaftierten auf Dauer der Zugang zu heute selbstverständlichen Tools und Kompetenzen einer digitalen Gesellschaft vorenthalten wird.
MicroRNA-302a enhances 5-fluorouracil sensitivity in HepG2 cells by increasing AKT/ULK1-dependent autophagy-mediated apoptosis
Authors: He Qiong , Li Li
Published: February 2024

Objectives

MicroRNA-302a (miR-302a) has been implicated in the oncogenic processes, but its role in hepatocellular carcinoma (HCC) chemoresistance and related mechanisms are still unclear. Therefore, the aim of this study was to investigate the role of miR-302a in HCC chemoresistance and elucidate its underlying mechanism.

Methods

In this study, we detected the level of miR-302a in HCC tissues (including chemoresistant and chemosensitive tissues), non-tumor tissues, liver cancer cell lines, and 5-fluorouracil (5-FU)-resistant cells (HepG2/R). Additionally, we conducted cell viability, apoptosis, and autophagy analyses as well as assessed the levels of cleaved caspase-3, cleaved caspase-9, microtubule-associated protein 1 light chain 3 beta II (LC3B-II), Akt, and UNC-51 like kinase 1 (ULK1) in HepG2 cells transfected with miR-302a mimic or inhibitor prior to 5-FU treatment. Lastly, we predicted the target of miR-302a and verified the relationship between miR-302a and Akt by luciferase reporter and functional repair assays.

Results

Our results revealed that miR-302a was down-regulated in HCC tissues (p<0.01), especially in chemoresistant tissues (p<0.01). Consistently, the miR-302a level exhibited a lower expression in HepG2/R cells compared to their parental cells (p<0.01). Furthermore, the 5-FU-induced apoptosis and autophagy of HepG2 cells were promoted by miR-302a over-expression and diminished by miR-302a inhibition (p<0.01). Target analysis revealed that miR-302a could directly target Akt. Moreover, miR-302a inhibited Akt expression and subsequently elevated ULK1 expression (p<0.01). Inhibition of ULK1 could abrogate the sensitization of overexpressed miR-302a to 5-FU in HepG2 cells (p<0.01).

Conclusions

Altogether, our results demonstrate that the down-regulation of miR-302a promotes 5-FU resistance in HCC by attenuating the Akt/ULK1 axis-dependent autophagy and apoptosis.
Optoelectronic–thermomagnetic effect of a microelongated non-local rotating semiconductor heated by pulsed laser with varying thermal conductivity
Authors: Raddadi Merfat H. , El-Sapa Shreen , Elamin Mahjoub A. , Chtioui Houda , Chteoui Riadh , El-Bary Alaa A. , Lotfy Khaled
Published: February 2024

In this study, we investigated the effect of a rotation field and magnetic field on a homogeneous photo-thermoelastic nonlocal material and how its thermal conductivity changes as a result of a linearly distributed thermal load. The thermal conductivity of an interior particle is supposed to increase linearly with temperature under the impact of laser pulses. Microelastic (microelements distribution), non-local semiconductors are used to model the problem under optoelectronic procedures, as proposed by the thermoelasticity theory. According to the microelement transport processes, the micropolar-photo-thermoelasticity theory accounts for the medium’s microelongation properties. This mathematical model is solved in two dimensions using the harmonic wave analysis. Non-local semiconductor surfaces can generate completely dimensionless displacement, temperature, microelongation, carrier density, and stress components with the appropriate boundary conditions. The effects of thermal conductivity, thermal relaxation times, magnetic pressure effect, laser pulses, and rotation parameters on wave propagation in silicon (Si) material are investigated and graphically displayed for a range of values.
The chronology of T-shaped antler axe technology in northeastern Europe
Authors: Lübke Harald , Rimkus Tomas , Meadows John , Vashanau Aliaksandr , Zagorska Ilga , Bērziņš Valdis , Butrimas Adomas , Charniauski Maxim , Daugnora Linas , Piezonka Henny
Published: February 2024

We present new AMS 14C dates and technological characteristics of an enigmatic osseous implement – the T-shaped antler axe. T-shaped axes (T-axes) are made of red deer (Cervus elaphus L.) antler beams with the perforation for a shaft through the removed trez tine. Our study centres on 33 axes from Belarus, Latvia and Lithuania, most of which were found during drainage of wetlands or sediment extraction in the 20th century, and thus remained unknown internationally. We successfully dated 19 of these artefacts, and here we compare their dates to published dates of T-shaped antler axes from western Europe (Belgium, The Netherlands, western Germany, Scotland), the southwestern Baltic (Denmark, northern Germany and northwestern Poland) and southeastern Europe (Ukraine). Radiocarbon results suggest the gradual spread of this specific antler tool producing technique from southern Europe towards the Baltic during the 6th millennium BC. The technological characteristics of T-axes in combination with the radiocarbon data enable us to preliminary discuss the chronology of aspects of T-axe production.
Current trends in the modernization of corporate law in Poland
Authors: Oliynyk O.S.
Published: February 2024

The article analyzes the latest trends in corporate law reform in Poland. The main emphasis is placed on the system of economic companies and the variety of subclasses of classical types of companies that should satisfy the needs of the modern economy (simple joint-stock company, limited joint-stock company).The author justifies that in the conditions of the initiated process of Ukraine’s integration into the EU, it is relevant to take into account the experience of other European countries that have gained membership in the European Union. Taking into account the experience of Poland seems especially appropriate, since the same challenges faced the Polish legislator among the EU member states: reformatting the economy in accordance with new market conditions, privatization, abolition of socialist legislation, etc.It is argued that an important feature of Polish corporate legislation is the division into partnerships and corporations. This line of demarcation follows the pattern known in most modern jurisdictions and has been developed by legal doctrine with the emergence of the theory of legal personality.Special attention is paid to limited joint-stock partnership and simple joint-stock company. It is emphasized that the double taxation of limited joint-stock partnership ‘s profit eliminated the main advantage of the latter. That is why, today, limited joint-stock partnerships are not popular in the process of conducting an existing or registering a new business. And a simple JSC is a potentially effective legal form of business, first of all, for technology companies.The author concludes that several attempts have been made in the corporate law of Poland to offer the market an effective tool for attracting equity capital (limited partnership on shares, simple joint-stock company). However, none of them has yet lived up to expectations. However, such attempts are a confirmation that the system of business associations is a dynamic phenomenon and periodically needs modernization in accordance with the socio-economic needs of a specific state.It is concluded that the polish experience of limited joint-stock partnership and simple joint stock company should be taken into account during further changes in Ukrainian corporation law, especially within the framework of the recodification of the Civil Code of Ukraine.
The experience of France regarding legal regulation of public-private partnership as a basis for the improvement of ukrainian legislation
Authors: Banach S.V.
Published: February 2024

The article is devoted to the study of the existing problem of institutional functioning of public-private partnership in Ukraine, the absence of PPP mechanisms with quasi-private entities, such as mixed economy communities (SEM) or quasi-public enterprises (SAEMES), and the absence of a single body in the field of PPP.To confirm the existence of problems in the field of low popularity of the PPP mechanism, the author provides statistics on the annual implementation of projects in Ukraine and other countries, such as Great Britain and France. Citing these figures, the author mentions the problem of the uncertainty of the Ukrainian approach to following the experience of the Anglo-Saxon or Romano-Germanic legal system.In addition, the article emphasizes the absence of a regulated mechanism for providing PPP projects with government guarantees and the absence of the possibility of reimbursing the private partner’s investments when the contract is changed at the initiative of the state partner.The author proposes to apply the experience of France and implement the mechanisms of public-private partnership with quasi-public enterprises, using the example of infrastructure development in Paris to establish a parking system. The author also draws on the experience in Cannes, where PPPs with quasi-public entities were used to improve the work of the museum.At the same time, it is emphasized that it is worth taking into account the lessons learned by France when implementing PPPs with quasi-public entities, such as the need to strengthen personnel specializing in contractual PPP obligations, the need to define a new model of approach to payments to a private partner - namely, regular provision of payments and subsidies to the private partner.The lack of government guarantees to ensure wider implementation of projects in the field of public-private partnership is also proposed to be resolved by adopting additional by-laws. The author paid special attention to the existence of a service body in the field of PPP in France - MAPPP. The author emphasizes that despite the fact that this body has numerous functions in France, in Ukraine such a body could become the only «service» PPP body.
Effects of single or combination of dietary vitamin C and β-glucan supplementation on golden trevally, \(\textit{Gnathanodon speciosus}\) (Carangidae)
Authors: Do Huu Hoang , Huynh Sang Minh , Nguyen Thi Nguyet Hue , Vo Hai Thi , Tran Thi Minh Hue , Huynh Thi Ngoc Duyen , Nguyen Tam Vinh
Published: February 2024

This study aims to test the single and combination effects of dietary vitamin C and β-glucan on golden trevally, Gnathanodon speciosus. The basal diet (D0) was added with vitamin C at 200 mg kg-1 diet (D1), β-glucan at 1.0 g kg-1 diet (D2), and a combination of vitamin C and β-glucan (200 mg vitamin C and 1 g β-glucan per kilogram diet) (D3). The diets were fed the fish for eight weeks. After eight weeks of diet feeding, the growth rate of the fish enhanced significantly with the presence of vitamin C, β-glucan, and the combination of Vitamin C and β-glucan (p < 0.05). The growth rate was significantly higher in a fish-fed diet combined with vitamin C and β-glucan. Survival rates were not significantly different among diet treatments. Muscle protein of fish ranged from 18.36–21.50% among diet treatments. Fish protein content in fish was not influenced by vitamin C, but the protein was higher in fish fed with the β-glucan-added diet and combination the β-glucan and vitamin C-added diet. The current results suggest that a supplemented combination of vitamin C and β-glucan could boost this golden trevally’s growth and body composition at the juvenile stage.
Una mirada desde la empleabilidad
Authors: MONTES GORDILLO OLGA LUCÍA , BECERRA PLAZA GISÉLE EUGENIA , KOEN MERCHÁN FELIPE , RINCÓN BÁEZ WILLIAM UMAR
Published: February 2024

Al estudiar la historia de la Administración, existe un elemento transversal y permanente en las diferentes épocas que ha experimentado nuestra profesión desde su nacimiento a finales del siglo XIX en EE.UU: una evolución constante. Naciendo desde un paradigma científico, que buscaba estudiar y controlar las condiciones de trabajo ideales para que estas fueran optimizadas en las fábricas, hasta un enfoque humanista que privilegia las necesidades y actitudes de los empleados, e inclusive la reciente administración emergente para “start-ups”, nuestra profesión ha cambiado a lo largo de las décadas a medida que las organizaciones y el mundo se han ido transformando.
El producto interno bruto (PIB)
Authors:   Universidad Cooperativa de Colombia, Coavas-Blanquicet Sami Gabriel , Romero Haddad Celene Margarita , Ruíz Padilla Guillermo David
Published: February 2024

Esta nota de clase proporciona una visión completa sobre el producto interno bruto (PIB), abordando su definición, componentes, formas de medir y limitaciones. El PIB se presenta como un indicador clave para medir la actividad económica de un país y evaluar su desempeño. Se explican detalladamente los componentes del PIB, que incluyen el consumo, la inversión, el gasto público y las exportaciones netas. Además, se exploran las distintas metodologías utilizadas para medir el PIB, como el enfoque del gasto, el ingreso y el valor agregado. También se destacan las limitaciones del PIB, como su incapacidad para capturar aspectos como la distribución del ingreso o el impacto ambiental. Este documento será una valiosa fuente de consulta para los estudiantes del curso de Agregados Económicos de la Facultad de Ciencias Administrativas, Contables y Afines, brindándoles un entendimiento sólido sobre el PIB y su importancia en el análisis económico. Les proporcionará una base para evaluar el desempeño económico, identificar áreas de mejora y tomar decisiones informadas en el ámbito empresarial y gubernamental. Asimismo, al abordar las limitaciones del PIB, los estudiantes adquirirán una perspectiva crítica que les permitirá considerar otros indicadores complementarios para una evaluación más completa de la economía. Lo anterior se realiza a través de ejemplos sencillos que vinculan lo teórico y práctico.
Assessing China's Efforts to Increase Self-Reliance
Authors: de Soyres Francois , Moore Dylan
Published: February 2024

Since the beginning of 2018, the United States and China have been increasing tariff rates on each other's imports, spurring debates about a possible fragmentation of trade into blocs of aligned countries (Pierce and Yu (2023), Alfaro and Chor (2023)). Later that year, in a November 2018 speech to workers at a state-owned enterprise, President Xi Jinping mentioned that current events were forcing China to "travel the road of self-reliance."
The Federal Reserve’s responses to the post-Covid period of high inflation
Authors: Ihrig Jane , Waller Chris
Published: February 2024

In the face of the COVID-19 pandemic in March 2020, the Federal Reserve committed to using its full range of tools to support the U.S. economy. Over the next year and a half, with progress on vaccinations and strong policy support, indicators of economic activity and employment strengthened while inflation moved higher. Faced with a tight labor market and elevated inflation, the Federal Open Market Committee (FOMC) began a process of unwinding the very accommodative stance of monetary policy and moving to a restrictive policy stance to address inflation pressures. Here we review the sequence of actions taken by the Committee between late 2020 and mid-2023 as well as discuss some issues it contemplated along the way; the table provides a chronological list of key events over this period.
The State of the Sanatorium-Resort Sphere of the Baikal Region in the Post-Pandemic Period
Authors: Rubtsova Natalia , Rzhepka Elina
Published: February 2024

As a result of the geopolitical crisis of the third decade of the XXI century in Russia, the number of available foreign destinations has decreased, which has led to a renewed interest of Russians to sanatorium and resort vacations within the country. As a result, sales in some sanatorium and resort facilities this year exceeded the figures of three years ago. At the same time, the cost of sanatorium and resort treatment in popular health resorts in the country increased to 40 %. The key factors stimulating the growth in demand for holidays in Russian sanatoriums, according to experts, are not only the inaccessibility of foreign destinations, but also the popularization of the tourist cashback program, as well as the effect of pent-up demand - during the COVID-19 pandemic, Russians refused to travel, resuming them after the removal of most health restrictions. However, the situation in the industry as a whole is not the same. Resorts located in regions with the greatest transport accessibility turned out to be in a winning position. On the territory of the regions of the Baikal region (Irkutsk region and the Republic of Buryatia) there is an almost complete range of sanatorium-and-spa institutions. Nevertheless, having significant potential, the sanatorium and resort sphere of the regions of the Baikal region still lags behind the industry leaders. The purpose of the article was to characterize the state and forecast development trends in the sanatorium and resort sector of the regions of the Baikal region in the post-pandemic period.
New Approaches to Internal Educational Migration
Authors: Trofimov Evgeny
Published: February 2024

The article analyzes domestic internal educational migration. Different views of scientists who have made a significant contribution to the development of the theory of migration are considered. Migration was assessed in terms of depopulation, when the death rate in recent years has been exceeding the birth rate in Russia. The author has substantiated correlation between economic laws, economic interests, incentives and migration. Educational migration has been divided into external and internal migration. The place, role and influence of internal educational migration on reproduction processes in Russia are shown. It is emphasized that in certain cases, internal educational migration should be considered as a specific form of local "brain drain", which manifests itself in a large number of young people in Siberia and the Far East wishing to continue their education in the central universities of the country. It is noted that after graduating from the capital's universities, most of them do not return to their home areas, which negatively affects the entire national reproduction process. The Western competence-based approach, which is the basis of domestic educational standards, is analyzed, its shortcomings are indicated. Proposals are made to improve the Federal State Educational Standards of Higher Education.
The Role of the Commissioner for Children's Rights in Providing Assistance in Resolving Family Disputes About Children (On the Example of the Irkutsk Region)
Authors: Zimina Ekaterina , Kopalkina Evgeniya , Chernyakova Tatiana , Gulyaeva Anastasia
Published: February 2024

The article describes the content of the activities of the Commissioner for Children's Rights in the Irkutsk region on issues of assistance in resolving family disputes. Statistical information for 2017-2021 is analyzed, revealing the structure of the topic and the reasons for appeals to the regional children's Ombudsman, taken from annual reports on the observance of the rights and legitimate interests of children in the Irkutsk region. It emphasizes terminological diversity and absence of basic legal concepts and principles, vagueness of their formulations in the Russian legislation regulating intra-family relations such as «child», «child interest», «the principle of the presumption of good faith of parents», «family disputes». The main conclusions of the review of judicial and legal practice in family cases related to the determination of the child’s place of residence when parents are separated, the manner of communication and participation in his or her upbringing are presented. The significance of family mediation in the settlement of family disputes has been disclosed, as has the attitude of the State and society towards its inclusion as an obligatory procedure in Russian legislation. The article analyses the foreign experience of the development of the institute of family mediation and the main tendencies of its development, the effectiveness of the Ombudsmen for the Rights of the Child in foreign countries depending on the model of establishment of their position. The destructive role of gatekeeping in resolving family disputes about children has been shown, the possibility of training a social work specialist as a professional mediator has been substantiated, The article analyses performance of a unique role of the family mediator of the Commissioner for the Rights of the Child in the Irkutsk region due to its specificity of legal and social status in the process of work on appeals of citizens on family disputes about children.
Increased Participation of Organizations in the Sphere of Building Materials Production in Public Procurements
Authors: Shchukina Tatyana , Gorchakova Maria
Published: February 2024

The research considers public procurement, which is one of the most important institutions of the public sector and a key mechanism for interaction with business structures. In the conditions of any type of economy, the state acts as the largest consumer of goods, works, services for public needs. In connection with the global trend of moving from traditional procurement, characterized by close cooperation, to a new order of budget constraints and the need to effectively meet public needs in conditions of limited resources, the principles of public procurement are changing. The issue of developing and implementing approaches to the effective management of participation in public procurement in commercial supplier organizations comes forefront. The content analysis and the literature review revealed that the issues of improving the mechanism of state (municipal) procurement in the Russian Federation as a whole have been studied from the point of view of improving legislation, eliminating methods of unfair competition in the contract system, and fighting corruption , strengthening control, stimulating the development of small and medium-sized businesses, etc. At the same time, the previous research did not examine the issues of analysis and assessment of the current state of the regional public procurement mechanism in conjunction with all-Russian trends, as well as local problems faced by individual customers and suppliers. The current study analyzes the issues of developing participation in public procurement of enterprises of manufacturers in the production of building materials based on an analysis of current trends in this area.
Lysosome analysis with confocal microscopy v1
Authors: Maassen Sjors
Published: February 2024

This protocol provides an overview of lysosomal analysis using confocal microscopy and Fiji
eDNA extraction from water samples filtered through 47 mm diameter filters (NucleoMag DNA/RNA Water Kit - MACHEREY NAGEL). v1
Authors: Vautier Marine
Published: February 2024

The objective of this protocol is the environmental DNA (eDNA) extraction from water samples filtered through 47 mm diameter filters. This protocol can be performed from filters preserved in tubes prefilled or not with preservation buffer. DNA extraction is performed using a MagnetaPure 32 Nucleic Acid Purification System (Dutscher) and with the NucleoMagDNA/RNA Water Kit (Macherey Nagel). The procedure is based on reversible adsorption of nucleic acids to paramagnetic beads under appropriate buffer conditions. The benefits of using the MagnetaPure 32 Nucleic Acid Purification System (Dutscher) are increased productivity and repeatability, as well as eliminating human error and the pain of repetitive work. This protocol is used prior to molecular biology analysis (e.g. qPCR, metabarcoding, ddPCR) to specifically target both macro- and micro-organisms eDNA extracted from water samples. This protocol is optimised for rare eDNA and the suggested elution volumes are therefore low (between 50 and 65 µL), but can be increased if targets are more abundant.
Protocol for "non-human primate necropsy" v1
Authors: not provided jlanciego
Published: February 2024

Here we describe the standard procedure conducted for performing a non-human primate necropsy, followed by removal of the brain and spinal cord from the skull and backbone, respectively.
Trajetória para implementação de programa de navegação de pacientes na oncologia: relato de experiência
Authors: Pautasso Fernanda Felipe , Trevilato Denilse Damasceno , Caregnato Rita Catalina Aquino , Floriani Maiara Anchau , Pertile Nicole de Moraes , Junior Antonio Dal Pizzol , Oliveira João Lucas Campos de
Published: February 2024

Objetivo: Descrever a trajetória para a implementação de um Programa de Navegação para pacientes oncológicos. Método: Estudo descritivo, tipo relato de experiência realizado em um Centro de Oncologia do Sul do Brasil. Resultados: O processo de implementação da navegação ocorreu em quatro etapas: a primeira iniciou com implementação da navegação para pacientes privados com câncer de cabeça e pescoço; a segunda envolveu o piloto do programa de navegação de pacientes com câncer de mama para entender as principais barreiras enfrentadas pelas pacientes; a terceira etapa, foi elaborar e aprovar a Política do Programa de Navegação Institucional. Na última, o Programa de Navegação da linha de cuidado da mama foi implementado para pacientes com indicação de neoadjuvância. Obteve-se redução de 70% na mediana de tempo de indicação e primeira consulta oncológica, de 28,6% no tempo entre sintoma e diagnóstico, 26,0% no tempo entre diagnóstico e início de tratamento. Conclusão: A implementação de um Programa de Navegação para pacientes com câncer exige dedicação e comprometimento institucional onde se evidencia um melhor cuidado oncológico, tendo o enfermeiro como protagonista da gestão e efetivação do processo.
Interrelation of sociodemographic and clinical factors with burnout and engagement among mothers, who joined online peer support networks for persons raising children with disabilities
Authors: Shishkova Alexandra M. , Bocharov Viktor V. , Chernaya Yulia S. , Shashkov Alexander V. , Porfirev Ivan V. , Titov Alexandr G.
Published: February 2024

BACKGROUND: Parents raising children with disabilities are often exposed to stress and emotional burnout associated not only with the parenting process itself, but also with the need to create special conditions for the development and maintenance of the physical and mental well-being of their children. It is important to reveal factors that determine the parents’ adaptation success in a child’s illness situation. Parents of disabled children often join communities via Internet in order to exchange experiences and competencies in the field of care and interaction with children. This is rapidly developing trend of modern society and requires close attention of psychologists and other specialists working with parents of children with disabilities. This knowledge will allow us to develop appropriate mechanisms for cooperation, treatment and prevention in relevant peer support networks. AIM: The aim of the study was to reveal the relationships of sociodemographic and clinical factors with the severity of burnout and engagement in child care in parents who joined online peer support networks for persons raising children with disabilities. MATERIALS AND METHODS: The study involved 125 parents (121 mothers and 4 fathers) caring for children with disabilities. Mean [±SD] age, 36,3 ± 6,7 years. The “Level of relatives’ emotional burnout / parent-child version” was used as an assessment tools. Also, semi-structured interview for assessing socio-demographic and clinical characteristics was applied. RESULTS: The results of the study showed that age of the mother and child, the education and the work activities of the mother, the child’s kindergarten attendance, the age of onset and duration of the child’s illness, the nature of the relationship with him and the degree of parent’s activity in the treatment and rehabilitation process are the factors associated with engagement and burnout in parents of children with disabilities who joined online peer support networks. In particular, the lesser the age of the mother and the disabled child, the more exhaustion, tendency to devaluate successes and achievements in the process of children’s treatment (inefficacy) and tendency to destructively defuse of stress tension in mothers. The process of exhaustion is most likely at the initial periods of adaptation of the mother to the disease of the child, then the adaptation to the existing situation occurs. Burnout acts as a pathological process that contradicts the general trend and develops in cases when, due to environmental or personal factors, difficulties in adapting the parent to the child’s disease arise. CONCLUSIONS: Understanding of parents’ burnout processes is important for moderators of Internet communities, since it allows to route work with information content.
Carbon Capture, Utilization, and Storage in Newfoundland and Labrador: A Simple Analysis of Viability of CCUS Systems and Technologies in the Canadian Province of Newfoundland and Labrador
Authors: Tong Robinson
Published: February 2024

Carbon Capture, Utilization and Storage (CCUS) is the only group of technologies that is known to decrease the amount of CO2 in the Earth’s biosphere, leading some experts to hail it as the cure for climate change. A significant number of CCUS projects have been implemented across the world and are being considered by many governments and policymakers, including the province of Newfoundland and Labrador. However, some are rightly skeptical of its perceived role as a cure for climate change. Through analyses of different CCUS technologies, the province’s needs and resources, the risks associated with CCUS, and the economics and politics of CCUS in the province, we have concluded that Newfoundland and Labrador possess not just the capability of CCUS, but the potential of a major sequestration project. We highlight the need for more data to support simulations and modeling for more accurate assessment of specific CCUS implementation in Newfoundland and Labrador, as well as funding and incentives for emitters to participate in CCUS – in short, it is imperative that Newfoundland and Labrador steeply accelerate its planning, simulation, development, and implementation of CCUS.
Septic arthritis following mumps in a case of steroid dependent nephrotic syndrome: a case report
Authors: Bhoomraddi Karan J. , Koshatwar Vaishnavi G. , Inamdar Prithi , Rai Rajesh K. , Naulakha Ravi P.
Published: February 2024

Nephrotic syndrome is a common renal disorder with an incidence of 20 to 40 per million population in developed countries. Children with nephrotic syndrome are especially susceptible to infections such as cellulitis, spontaneous bacterial peritonitis, and bacteremia. However, septic arthritis is an extremely rare complication in nephrotic syndrome. A 6-year-old girl with steroid dependent nephrotic syndrome relapsed following mumps parotitis and developed swelling of the right knee with restricted movements. Ultrasonography (USG) and magnetic resonance imaging (MRI) were suggestive of septic arthritis. The child responded to intravenous Vancomycin and Ceftazidime. We present a rare complication of nephrotic syndrome as septic arthritis, previously reported only once.
Pyrexia of unknown origin in a healthy adult: a case report
Authors: Sam Karun S. , Chawla Kunal , Dessai Rishikesh , Gulati Shipra
Published: February 2024

A 23-year-old male, with no known co-morbid illnesses, presented with a history of chronic fever and left hip pain of 6-months duration. The persistence of the fever with the progressive worsening of pain despite outpatient management prompted him to seek further evaluation. He was evaluated outside on multiple occasions and was diagnosed with a left sacroiliitis with left gluteal and paraspinal fluid collection 2 months prior, for which he was initiated on empirical anti tubercular treatment (ATT). In view of worsening of symptoms, he presented to our centre where he underwent a curettage and bone grafting of the left SI joint following repeat imaging. Tissue culture grew Cryptococcus neoformans and he was started on liposomal Amphoterecin B with Flucytosine. Patient clinically improved and was discharged on the same regimen. This case report aims shed light on the evidence of primary skeletal cryptococcal infection in an immunocompetent individual.
Satanismo e bruxaria na inquisição portuguesa
Authors: Trindade de Souza Felipe
Published: February 2024

O presente trabalho objetiva compreender a crença da Inquisição Moderna na existência de bruxos e satanistas. Assim, por meio desta pesquisa será possível apontar o século XV como o ponto de virada nos assuntos ligados a bruxaria e demonolatria, tendo em vista que inquisidores e teólogos passaram a defender que os poderes de bruxos e satanistas era real e, por isso, deveriam ser punidos. O artigo tomou como fonte de análise o monitório do inquisidor geral de Portugal, dom Diogo da Sylva, publicado em 1536. No tratamento dos dados foi empregado uma noção etnográfica, tal como a defendida por Robert Darnton (1984), na qual se busca entender o universo mental dos nativos através das fontes históricas. Os resultados obtidos nos levaram a concluir que a crença na existência de bruxos e satanistas fundamentou a repressão de resquícios pagãos e o uso de grupos sociais como bode expiatório para aliviar tensões sociais
Writing an Impactful Introduction in Business and Management Research: Avoiding Common Pitfalls
Authors: Fodouop Kouam Arthur William
Published: February 2024

A research study's impact and effectiveness heavily rely on the quality of its introduction. However, researchers often encounter common pitfalls that hinder the success of their introductions. This study addresses these challenges and provides guidelines for writing impactful introductions in academic research. By examining the common mistakes in introductions, such as lack of clarity, ineffective framing of the research problem, inadequate synthesis of previous studies, lack of engagement, and poor structure and organization, researchers can avoid these pitfalls and enhance the impact of their work. The study identifies these common pitfalls, analyzes their impact on the overall effectiveness of the study, and offers guidelines and recommendations for crafting engaging introductions. By following these guidelines, researchers can establish a strong foundation for their studies and effectively communicate their research goals to a broad audience, ultimately contributing to the success of their business and management research.
Investigating the Role of Optimism and Resilience on the Effect of Work Engagement on Emotional Exhaustion and Workplace Deviant Behaviors
Authors: Chiyangwa Rumbidzai , Muponya Isaac
Published: February 2024

Under what situations can work engagement predict emotional exhaustion? Working with the idea that work engagement and emotional exhaustion are two endpoints of a continuum, we relied on the conservation of resources (COR) theory – which evaluates them as two different variables – to undertake a multi-context, two-study research among bankers and miners. We asserted that work engagement would increase emotional exhaustion for people who are scaled lower in the optimism individual trait. Additionally, we recognized a three-way interaction, wherein work engagement heightened emotional exhaustion for less-optimistic persons who are also not resilient, while oppositely minimizing emotional exhaustion for high-optimism persons who are resilient. Our findings also lend credence to a moderated-mediation model, suggesting that when both optimism and resilience are high, deviant conduct in the workplace is reduced because workers are less emotionally exhausted from their work. We provide suggestions for future studies on work engagement and workplace deviant behavior.