bluuebunny/crossref_metadata_2025 huggingface dataset:
Possible existence of traversable wormhole in Finsler–Randers geometry
Authors: Das Krishna Pada , Debnath Ujjal
Published: September 2023

In the present article, we have explored the possible existence of a traversable wormhole in the framework of Finsler–Randers (F–R) geometry. In order to achieve this goal, first, we have constructed gravitational field equations for static, spherically symmetric spacetime with anisotropic fluid distribution in F–R geometry. Next, we have written the deduced form of field equations in the background of Morris–Thorne wormhole geometry. To visualize the shape of the wormhole, we have selected exponential shape function $$b(r)=\frac{r}{exp\left( \eta \left( \frac{r}{r_{0}} - 1\right) \right) }$$

b

(
r
)

=

r

e
x
p

η

r

r
0

-
1

with the constant parameter $$\eta $$
η
and the throat radius $$r_{0}$$

r
0

and depicted two-dimensional and three-dimensional embedding diagrams corresponding to some considered values of $$\eta $$
η
and $$r_{0}$$

r
0

. Moreover, all essential requirements to build a wormhole shape have been examined for the reported shape function. Next, We have analyzed wormhole configuration for three cases (I, II, III) corresponding to three selected redshift functions. Furthermore, each case is analyzed by dividing it into two models such as (i) Model-1 (for general anisotropic EoS $$p_{t}=\chi p_{r}$$

p
t

=
χ

p
r

) and (ii) Model-2 (for linear phantom-like EoS $$p_{r} + \omega \rho =0$$

p
r

+
ω
ρ
=
0

). In each model of three cases, we have verified the validity of the wormhole solution in F–R geometry by considering null, weak, strong and dominant energy conditions. Also, the total amount of averaged NEC-violating matter near the wormhole throat has been analyzed by computing volume integral quantifier.
Production of excited doubly heavy baryons at the super-Z factory
Authors: Niu Juan-Juan , Li Jing-Bo , Bi Huan-Yu , Ma Hong-Hao
Published: September 2023

In the framework of nonrelativistic QCD, the excited doubly heavy baryons are thoroughly studied via the channel $$e^{+} e^{-}\rightarrow \langle QQ^{\prime }\rangle [n] \rightarrow \Xi _{QQ^{\prime }} +\bar{Q^{\prime }} +{\bar{Q}}$$

e
+

e
-

→

⟨
Q

Q
′

⟩

[
n
]

→

Ξ

Q

Q
′

+

Q
′

¯

+

Q

¯

, which takes place at the collision energy Z-pole. $$Q^{(\prime )}$$

Q

(
′
)

represents b or c quark for the production of $$\Xi _{cc}$$

Ξ

cc

, $$\Xi _{bc}$$

Ξ

bc

, and $$\Xi _{bb}$$

Ξ

bb

, respectively. All of the intermediate diquark states $$\langle QQ'\rangle [n]$$

⟨
Q

Q
′

⟩

[
n
]

in P-wave, $$\langle cc\rangle [^{1}P_{1}]_{{\bar{\textbf{3}}}}$$

⟨
c
c
⟩

[
1

P
1

]

3

¯

, $$\langle cc\rangle [^{3}P_{J}]_{{\textbf{6}}}$$

⟨
c
c
⟩

[
3

P
J

]

6

, $$\langle bc\rangle [^{1}P_{1}]_{{\bar{\textbf{3}}}/ {\textbf{6}}}$$

⟨
b
c
⟩

[
1

P
1

]

3

¯

/
6

, $$\langle bc\rangle [^{3}P_{J}]_{{\bar{\textbf{3}}}/ {\textbf{6}}}$$

⟨
b
c
⟩

[
3

P
J

]

3

¯

/
6

, $$\langle bb \rangle [^{1}P_{1}]_{{\bar{\textbf{3}}}}$$

⟨
b
b
⟩

[
1

P
1

]

3

¯

, and $$\langle bb\rangle [^{3}P_{J}]_{{\textbf{6}}}$$

⟨
b
b
⟩

[
3

P
J

]

6

with $$J=0$$

J
=
0

, 1, or 2, are taken into account. The cross sections and differential distributions, including the transverse momentum, rapidity, angular, and invariant mass, are discussed for the excited baryons production. We find that the contributions of $$\langle cc \rangle $$

⟨
c
c
⟩

, $$\langle bc \rangle $$

⟨
b
c
⟩

, and $$\langle bb \rangle $$

⟨
b
b
⟩

in P-wave are found to be 3.97$$\%$$
%
, 5.08$$\%$$
%
, and 5.89$$\%$$
%
, respectively, compared to S-wave. Supposing that all excited states can decay into the ground state 100%, the total events $$N_{\Xi _{cc}}=8.48 \times 10^{4-6}$$

N

Ξ

cc

=
8.48
×

10

4
-
6

, $$N_{\Xi _{bc}}=2.26\times 10^{5-7}$$

N

Ξ

bc

=
2.26
×

10

5
-
7

, and $$N_{\Xi _{bb}}=4.12 \times 10^{3-5}$$

N

Ξ

bb

=
4.12
×

10

3
-
5

would be produced at the Super-Z Factory with a high luminosity up to $${{\mathcal {L}}} \simeq 10^{34-36}\textrm{cm}^{-2} \textrm{s}^{-1}$$

L
≃

10

34
-
36

cm

-
2

s

-
1

.
Cryptographic group and semigroup actions
Authors: Gnilke Oliver W. , Zumbrägel Jens
Published: September 2023

We consider actions of a group or a semigroup on a set, which generalize the setup of discrete logarithm based cryptosystems. Such cryptographic group actions have gained increasing attention recently in the context of isogeny-based cryptography. We introduce generic algorithms for the semigroup action problem and discuss lower and upper bounds. Also, we investigate Pohlig–Hellman type attacks in a general sense. In particular, we consider reductions provided by non-invertible elements in a semigroup, and we deal with subgroups in the case of group actions.
A multi-sensor fusion method for static Chinese sign language recognition using DE–XGBoost
Authors: Lu Xiaoyang , Liu Yanjun
Published: September 2023

Static Chinese Sign Language Recognition (SCSLR) is an important field of research in human–computer interaction and assistive technology. Traditional SCSLR methods usually rely on computer vison sensors, which are susceptible to effects such as hand shapes, lighting conditions, and occlusions, resulting in low recognition accuracy. Additionally, sensor-based SCSLR methods cannot achieve high recognition accuracy due to limited hand gesture information. In this paper, we propose a multi-sensor fusion method, using a DE–XGBoost model, to fuse the information of hand gesture and finger curvature to achieve the SCSLR, which can overcome the recognition error problems caused by insufficient sign language information. In addition, we design and implement a prototype system, which consists of a smartphone and a smart glove, to evaluate our proposed method in comparison with support vector machine (SVM), XGBoost, gcForest, and artificial neural network (ANN). Experimental results show that our proposed method achieves a better performance in terms of accuracy, robustness, and real-time processing.
Role of Virtual Water Trade Under the Generalized Trade Framework in Xinjiang’s Economic Sustainable Development
Authors: Tang Chao , Liu Yong
Published: September 2023

Xinjiang had been suffering from acute water scarcity, which is an important constraint factor for its economic sustainability. Virtual water plays an important role in its sustainable development, and this paper tries to re-investigate the role of virtual water trade among the generalized trade framework in its sustainable development. The term generalized trade encompasses both physical and virtual trade. Physical trade refers to the transfer of commodities in monetary or barter form, and virtual trade refers to the transfer of inputs embodied in physical form (e.g., virtual water, energy, or land). It was in the water-scarce status, but it transported a net volume of about 13.1 billion tons of water to other economies, 94.6% of which was transported to other provinces. This phenomenon is contradictory to the comparative advantage theory. Water is a critical input in the production of commodities, but it is only one factor from the perspective of generalized trade. It is rich in energy resources but imports a large amount of external virtual energy from other provinces. Many labors come to Xinjiang both in physical and virtual senses. This situation indicates that generalized trade plays a more important role, and suggests that it should continue to improve its industrial system and optimize its business environment.
ExHiPR: Extended High-Level Partial Reconfiguration for Fast Incremental FPGA Compilation
Authors: Xiao Yuanlong , Park Dongjoon , Niu Zeyu Jason , Hota Aditya , Dehon André
Published: September 2023

Partial Reconfiguration (PR) is a key technique in the application design on modern FPGAs. However, current PR tools heavily rely on the developer to manually conduct PR module definition, floorplanning, and flow control at a low level. The existing PR tools do not consider High-Level-Synthesis languages either, which are of great interest to software developers. We propose HiPR, an open-source framework, to bridge the gap between HLS and PR. HiPR allows the developer to define partially reconfigurable C/C++ functions, instead of Verilog modules, to accelerate the FPGA incremental compilation and automate the flow from C/C++ to bitstreams. We use a lightweight Simulated Annealing floorplanner and show that it can produce high-quality PR floorplans an order of magnitude faster than analytic methods. By mapping Rosetta HLS benchmarks, we demonstrate that the incremental compilation can be accelerated by 3–10× compared with state-of-the-art Xilinx Vitis flow without performance loss, at the cost of 15–67% one-time overlay set-up time.
The Open-source DeLiBA2 Hardware/Software Framework for Distributed Storage Accelerators
Authors: Khan Babar , Heinz Carsten , Koch Andreas
Published: September 2023

With the trend towards ever larger “big data” applications, many of the gains achievable by using specialized compute accelerators become diminished due to the growing I/O overheads. While there have been several research efforts into computational storage and FPGA implementations of the NVMe interface, to our knowledge, there have been only very limited efforts to move
larger
parts of the Linux block I/O stack into FPGA-based hardware accelerators. Our hardware/software framework DeLiBA initially addressed this deficiency by allowing high-productivity development of software components of the I/O stack in user instead of kernel space and leverages a proven FPGA SoC framework to quickly compose and deploy the actual FPGA-based I/O accelerators. In its initial form, it achieves 10% higher throughput and up to 2.3× the I/Os per second (IOPS) for a proof-of-concept Ceph accelerator running in a real multi-node Ceph cluster. In DeLiBA2, we have extended the framework further to better support
distributed
storage systems, specifically by directly integrating the block I/O accelerators with a hardware-accelerated network stack, as well as by accelerating more storage functions. With these improvements, performance grows significantly: The cluster-level speedups now reach up to 2.8× for
both
throughput and IOPS relative to Ceph in software in synthetic benchmarks and achieve end-to-end wall-clock speedups of 20% for the real workload of building a large software package.
Exploring Alternative Futures in the Anthropocene
Authors: Cork Steven , Alexandra Carla , Alvarez-Romero Jorge G. , Bennett Elena M. , Berbés-Blázquez Marta , Bohensky Erin , Bok Barbara , Costanza Robert , Hashimoto Shizuka , Hill Rosemary , Inayatullah Sohail , Kok Kasper , Kuiper Jan J. , Moglia Magnus , Pereira Laura , Peterson Garry , Weeks Rebecca , Wyborn Carina
Published: September 2023

Many challenges posed by the current Anthropocene epoch require fundamental transformations to humanity's relationships with the rest of the planet. Achieving such transformations requires that humanity improve its understanding of the current situation and enhance its ability to imagine pathways toward alternative, preferable futures. We review advances in addressing these challenges that employ systematic and structured thinking about multiple possible futures (futures-thinking). Over seven decades, especially the past two, approaches to futures-thinking have helped people from diverse backgrounds reach a common understanding of important issues, underlying causes, and pathways toward optimistic futures. A recent focus has been the stimulation of imagination to produce new options. The roles of futures-thinking in breaking unhelpful social addictions and in conflict resolution are key emerging topics. We summarize cognitive, cultural, and institutional constraints on the societal uptake of futures-thinking, concluding that none are insurmountable once understood.
The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced Rats
Authors: Purnomo Hery D. , Kusuma Refani A. , Sianturi Elfrida , Haroen Ryan F. , Solichin Muchamad R. , Nissa Choirun , Pramono Adriyan , Mahati Endang , Noer Etika R.
Published: September 2023

Liver damage characterized by fibrosis and necrosis can worsen the condition of liver disease. Liver disease is associated with impaired immune response and may affect short-chain fatty acid (SCFA) gut metabolites. Hepatogomax enteral formula was developed, which contains brain-chain amino acids (BCAAs) and middle-chain triglycerides (MCTs), which could repair liver tissue damage, improve the inflammatory status, and modulate SCFA in liver damage. The study aimed to determine the effect of hepatogomax on liver tissue repair, inflammation (TNF-α and IL-6), and SCFA levels in thioacetamide (TAA)-induced rats. The induction of TAA causes liver steatosis, increasing TNF-α and IL-6, and decreasing SCFA levels. Hepatogomax at a dose of 14.6 g/200 gBW significantly reduces TNF-α and IL-6 levels and increases SCFA levels (

p

 < 0.05). The number of steatosis between groups P2 and P3 was lower as compared to a group of negative control [K2] (

p

 < 0.05). Hepatogomax, in a dose-dependent manner, may repair liver tissue and improve inflammatory response and SCFA levels in TAA-induced rats.
Prevalence of Depression and Associated Factors among Adults in Saudi Arabia: Systematic Review and Meta-Analysis (2000-2022)
Authors: Nour Mohamed O. , Alharbi Khulud K. , Hafiz Tamara Abdulrahman , Alshehri Ali M. , Alyamani Lujain Sami , Alharbi Taif Hazzaa , Alzahrani Reuof Saleh , Almalki Ebtehal Fawwaz , Althagafi Asayel Atiah , Kattan Ebtesam Tariq , Tamim Hala Mamun
Published: September 2023

Introduction. Depressive disorders are the leading causes of disability and disease burden worldwide. They were ranked fifth among the top causes of death and disability in Saudi Arabia, with subsequent impacts on productivity and economics when affecting adults. Objectives. The study aimed to systematically investigate the prevalence of depression and its associated factors among Saudi adults during 2000-2022. Methods. A systematic review and meta-analysis were conducted in accordance with the PRISMA guidelines using Medline/PubMed, ResearchGate, Google Scholar, and Ovid databases during 2000-2022 with predetermined inclusion and exclusion criteria. The quality of the included papers was determined, and heterogeneity between studies was assessed using the Q statistic to estimate theI2value. A random effects model was used to drive the pooled depression prevalence with 95% confidence intervals (CI). A forest plot was generated to show estimates for individual studies. Publication bias was assessed visually with the funnel plots symmetry and Egger’s test (p<0.05). A sensitivity analysis was conducted to explore the effect of individual studies on the overall prevalence estimate. A subgroup analysis by the study, population characteristics, and depression tools were also run. Results. Forty-six cross-sectional relevant studies were identified, including 25814 participants. The pooled depression prevalence was 37.35% (95% CI: 33.61–41.98%) with high heterogeneity (I2=94.8%,p<0.001). In the subgroup analysis, the prevalence estimates were higher among females (34.5%), the singles (49.5%), undergraduate university students in university settings (47.7%), northern region (62.3%), and studies that utilized the Center for Epidemiological Studies-Depression (CES-D) scale (58.8%). Among the risk factors significantly associated with depression were female gender, being single, low education level, financial problems, poor housing condition, having medical problems, sleep disorders, presence of psychiatric/psychological conditions, life events, lack of social support, exposure to stress, educational/personal problems, and smartphone addiction. Conclusion. Almost more than one-third of Saudi adults had depression. Appropriate surveillance, early interventions, and depression management strategies are needed to decrease the prevalence and its consequences among adults.
Prevalence and Management of Transfusional Iron Overload in Syrian Beta Thalassemia Major Patients Pre and during the Syrian Conflict
Authors: Touma Hanan , Youssef Lama A. , Al-Salhi Lana , Ismail Al-khalil Wouroud , AlKeba Khawla
Published: September 2023

Objectives. The primary aim of this study was to evaluate the prevalence of iron overload and the real‐world clinical effectiveness of the iron chelation therapies (ICTs) in Syrian patients with transfusion‐dependent beta thalassemia major (BTM) prior to and during the ongoing Syrian conflict. Methods. This single‐center, two‐stage observational study was conducted at Homs National Thalassemia Center (HNTC) prior to (2009) and during (2019) the armed conflict. The prevalence and the severity of iron overload, as well as the effectiveness of four iron chelation regimens, were assessed using serum ferritin (SF) concentrations as a means of monitoring in two cohorts of BTM patients receiving deferoxamine (DFO), deferiprone (DFP), deferasirox (DFX), or a combination of DFO and DFP therapy in both years. Statistical analyses encompassed one‐way ANOVA, Kruskal‐Wallis, Mann–Whitney U, and chi‐square (χ2) tests for the comparisons of the variables and the frequencies between the two cohorts and subgroups. Results. We included all eligible BTM patients at HNTC in 2009 (n = 205) and 2019 (n = 172). Only 84 patients from the 2009 cohort were accessible in 2019. Our findings revealed that 98% and 89% of the patients had iron overload (SF ≥ 1500 ng/mL) and comparable elevated median SF concentrations (3868 and 3757 ng/mL) in 2009 and 2019, respectively (P = 0.275). Furthermore, patients on DFO demonstrated the poorest control of iron overload and the highest SF concentrations (4319 and 5586 ng/mL), whereas those on DFX achieved superior outcomes and the lowest SF concentrations (3355 and 2152 ng/mL) in both years. Twenty‐six patients from the 2019 cohort received no ICT for six years (from 2012 to 2018) and experienced extremely severe iron overload with SF levels ranging between 4481 and 16,000 ng/mL. Conclusions. Our findings prove a high prevalence of iron overload and suboptimal chelation outcomes in Syrian BTM patients, both prior to and during the ongoing armed conflict, despite the provision of free ICTs at HNTC. Poor adherence and older age of patients may explain the unfavorable outcomes of DFO and (DFO+DFP) regimens, whereas younger age and higher socioeconomic status may have contributed to the lowest SF and superior outcomes in patients on DFX. This study also demonstrates the crucial role of the National Thalassemia Centers, namely HNTC, in providing health services to BTM patients in times of peace and conflict.
Modeling Nile Tilapia Heterogeneous Growth under Different Stocking Densities during Pre-Grow-Out Stage
Authors: Fuentes-Andraca V. H. , Araneda-Padilla M. E. , Domínguez-May R. , Gullian-Klanian M. , Marin-Coria E. J. , Quintana-Casares J. C. , Peñalosa-Martinell D. , Ponce-Díaz G.
Published: September 2023

The heterogeneous and homogeneous growth (HmG) assumptions in an intensive tilapia Oreochromis niloticus pre-grow-out production were evaluated under the different stocking scenarios. Four growth models (von Bertalanffy, Logistic, Pütter, and Gompertz) were tested and modified to include the effect of stocking density and growth difference. Models with homogeneous growth were fitted using a nonlinear regression, while heterogeneous growth (HtG) models were parameterized using quantile (0.05, 0.15, 0.25, 0.50, 0.75, 0.85, and 0.95) regression. According to goodness of fit and validation, the models that best fit homogeneous and HtG were Logistic and von Bertalanffy, respectively, which confirm the existence of the dense dependency effect on growth performance. Density and growth have an inversely proportional relationship. Quantile regression provided greater efficiency in predicting growth of the different groups of individuals in the population. The results obtained can be used by the aquaculture farmer to select stocking management strategies and optimal transfer time for tilapia juveniles.
Effects of Solid-State Fermentation with the Ganoderma spp. and Coriolus versicolor on the Total Phenol Contents and Antioxidant Properties on Black Soybean
Authors: Li Yanting , Xu Lina , Guo Shang
Published: September 2023

Aim of this study was to evaluate the influence of solid-state fermentation of 4 strains ((Ganoderma oregonense (GO), Ganoderma lucidum (GL), Ganoderma sinensis (GS), and Coriolus versicolor (CV))) on the nutrients, functional ingredients, and antioxidant activity in black soybean. As a result, after fermentation by 3 strains of Ganoderma spp. and CV, the contents of crude protein, crude fat, reducing sugar, soluble protein, triterpenoid, and total phenol contents in black soybean significantly increased

P
 
<
 
0.01

, particularly in CV-black soybean. The contents of crude protein, crude fat, reducing sugar, soluble protein, and total phenol were 122.92%, 132.69%, 290.08%, 122.58%, and 142.47% higher than those of the control groups, respectively. But the total sugar and crude fiber contents decreased significantly

P
 
<
 
0.01

. Furthermore, analysis of antioxidant capacity showed that all the fermented products had scavenging effects on DPPH, hydroxyl, and superoxide anion radicals. In addition, the DPPH scavenging ability of CV fermented products was highest, the hydroxyl radical scavenging ability of GS fermented products was highest, and the superoxide anion radical scavenging ability of GO fermented products was highest, which were 9.43, 7.65, and 3.39 folds higher than those of control groups, respectively. All results evidenced that the fermented strains and the fermented time had remarkable influences on the nutritional ingredient and antioxidant activity of fermented products in black soybean. Also, there was a significant correlation between total phenolic content and antioxidant activities. In conclusion, fermented black soybean with fungus has the potential to be developed into a functional food and nutraceutical material.
Prediction of Risk of Metastatic Recurrence for Female Breast Cancer Patients in the Presence of Competing Causes of Death
Authors: Mariotto Angela B. , Botta Laura , Bernasconi Alice , Zou Zhaohui , Gatta Gemma , Capocaccia Riccardo
Published: September 2023

Background:

To estimate risk of recurrence for women diagnosed with nonmetastatic breast cancer considering the risks of other causes mortality.

Methods:

We extend a method based on the diagnosis–metastasis–death pathway to include risks of other causes mortality. We estimate three probabilities as cumulative incidence of: (i) being alive and recurrence-free, (ii) death for other causes before a recurrence, and (iii) recurrence. We apply the method to female breast cancer relative survival from the Surveillance, Epidemiology, and End Results Program registries (2000–2018) data.

Results:

The cumulative incidence of recurrence shows a higher increase with more advanced cancer stage and is less influenced by age at diagnosis. At 5 years from diagnosis, the cumulative incidence of recurrence is less than 3% for those diagnosed with stage I, 10% to 13% for those diagnosed with stage II, and 37% to 47% for those diagnosed with stage III breast cancer. The estimates of recurrence considering versus ignoring the risks of dying from other causes were generally consistent, except for older women with more advanced stage, and longer time since diagnosis. In these groups, the net probability of recurrence, excluding the risks of dying from other causes, were overestimated.

Conclusions:

For patients with cancer who are older or long-term survivors, it is important to include the risks of other cause mortality as the crude cumulative incidence of recurrence is a more appropriate measure.

Impact:

These estimates are important in clinical decision making, as higher competing mortality may preclude the benefits of aggressive treatments.
Early Immune Changes Support Signet Ring Cell Dormancy in CDH1-Driven Hereditary Diffuse Gastric Carcinogenesis
Authors: Green Benjamin L. , Gamble Lauren A. , Diggs Laurence P. , Nousome Darryl , Patterson Jesse C. , Joughin Brian A. , Gasmi Billel , Lux Stephanie C. , Samaranayake Sarah G. , Miettinen Markku , Quezado Martha , Hernandez Jonathan M. , Yaffe Michael B. , Davis Jeremy L.
Published: September 2023

Stage IA gastric adenocarcinoma, characterized by foci of intramucosal signet ring cells (SRC), is found in nearly all asymptomatic patients with germline pathogenic CDH1 variants and hereditary diffuse gastric cancer syndrome (HDGC). The molecular steps involved in initiating malignant transformation and promoting SRC dormancy in HDGC are unknown. Here, whole-exome bulk RNA sequencing (RNA-seq) of SRCs and adjacent non-SRC epithelium (NEP) was performed on laser-capture microdissected (LCM) regions of interest found in risk-reducing total gastrectomy specimens from patients with HDGC (Clinicaltrials.gov ID: NCT03030404). In total, 20 patients (6 male, 14 female) with confirmed HDGC were identified. Analysis of differentially expressed genes (DEG) demonstrated upregulation of certain individual EMT and proliferation genes. However, no oncogenic pathways were found to be upregulated in SRCs. Rather, SRC regions had significant enrichment in pathways involved in T-cell signaling. CIBERSORTx predicted significant increases in the presence of regulatory T cells (Treg) specific to SRC regions. IHC confirmed an increase in FOXP3+ cells in SRC foci, as well as elevations in CD4+ T cells and HLA-DR staining. In summary, the tumor immune microenvironment is microscopically inseparable from stage IA gastric SRCs using a granular isolation technique. An elevation in CD4+ T cells within SRC regions correlates with clinically observed SRC dormancy, while Treg upregulation represents a potential immune escape mechanism.

Implications:

Characterization of the tumor–immune microenvironment in HDGC underscores the potential for the immune system to shape the transcriptional profile of the earliest tumors, which suggests immune-directed therapy as a potential cancer interception strategy in diffuse-type gastric cancer.
TABLE 1 from A Phase I Study of the Pan-Notch Inhibitor CB-103 for Patients with Advanced Adenoid Cystic Carcinoma and Other Tumors
Authors: Hanna Glenn J. , Stathis Anastasios , Lopez-Miranda Elena , Racca Fabricio , Quon Doris , Leyvraz Serge , Hess Dagmar , Keam Bhumsuk , Rodon Jordi , Ahn Myung-Ju , Kim Hye Ryun , Schneeweiss Andreas , Ribera Josep-Maria , DeAngelo Daniel , Perez Garcia Jose Manuel , Cortes Javier , Schönborn-Kellenberger Oliver , Weber Dirk , Pisa Pavel , Bauer Michael , Beni Laura , Bobadilla Maria , Lehal Raj , Vigolo Michele , Vogl Florian D. , Garralda Elena
Published: September 2023

Patient demographics
Supplementary Table 2 from A Phase I Study of the Pan-Notch Inhibitor CB-103 for Patients with Advanced Adenoid Cystic Carcinoma and Other Tumors
Authors: Hanna Glenn J. , Stathis Anastasios , Lopez-Miranda Elena , Racca Fabricio , Quon Doris , Leyvraz Serge , Hess Dagmar , Keam Bhumsuk , Rodon Jordi , Ahn Myung-Ju , Kim Hye Ryun , Schneeweiss Andreas , Ribera Josep-Maria , DeAngelo Daniel , Perez Garcia Jose Manuel , Cortes Javier , Schönborn-Kellenberger Oliver , Weber Dirk , Pisa Pavel , Bauer Michael , Beni Laura , Bobadilla Maria , Lehal Raj , Vigolo Michele , Vogl Florian D. , Garralda Elena
Published: September 2023

Pharmacokinetic parameters for CB-103
Supplementary Figure 2 from A Phase I Study of the Pan-Notch Inhibitor CB-103 for Patients with Advanced Adenoid Cystic Carcinoma and Other Tumors
Authors: Hanna Glenn J. , Stathis Anastasios , Lopez-Miranda Elena , Racca Fabricio , Quon Doris , Leyvraz Serge , Hess Dagmar , Keam Bhumsuk , Rodon Jordi , Ahn Myung-Ju , Kim Hye Ryun , Schneeweiss Andreas , Ribera Josep-Maria , DeAngelo Daniel , Perez Garcia Jose Manuel , Cortes Javier , Schönborn-Kellenberger Oliver , Weber Dirk , Pisa Pavel , Bauer Michael , Beni Laura , Bobadilla Maria , Lehal Raj , Vigolo Michele , Vogl Florian D. , Garralda Elena
Published: September 2023

Pharmacokinetic parameters
Editorial
Authors: Nascimento Flávia Brito do
Published: September 2023

A nova edição da Revista CPC número 35 apresenta um panorama do universo ampliado das complexidades do patrimônio cultural no Brasil, com textos e reflexões que apontam para os muitos caminhos que as pesquisas nacionais têm tomado. O conjunto de artigos vai do edificado ao urbano, das questões da educação patrimonial aos problemas técnicos da conservação, chegando aos temas da diversidade sexual e das políticas e legislações de salvaguarda do patrimônio.
Treatment and Control of Hypertension Among Adults With Chronic Kidney Disease, 2011 to 2019
Authors: Martinez Joshua D. , Thomas I-Chun , Montez-Rath Maria E. , Pao Alan C. , Fung Enrica , Charu Vivek , Sim John J. , An Jaejin , Odden Michelle C. , Kurella Tamura Manjula
Published: September 2023

BACKGROUND:

Hypertension frequently accompanies chronic kidney disease (CKD) as etiology and sequela. We examined contemporary trends in hypertension treatment and control in a national sample of adults with CKD.

METHODS:

We evaluated 5% cross-sectional samples of adults with CKD between 2011 and 2019 in the Veterans Health Administration. We defined CKD as a sustained estimated glomerular filtration rate value <60 mL/min per 1.73 m
2
or a urine albumin-to-creatinine ratio ≥30 mg/g. The main outcomes were blood pressure (BP) control, defined as a systolic BP <140 mm Hg and a diastolic BP <90 mm Hg based on the mean of monthly BP measurements, and prescriptions for antihypertensive medications.

RESULTS:

The annual samples ranged between n=22 110 and n=33 039 individuals, with a mean age of 72 years, 96% of whom were men. Between 2011 and 2014, the age-adjusted proportion of adults with controlled BP declined from 78.0% to 72.2% (
P
value for linear trend, <0.001), reached a nadir of 71.0% in 2015, and then increased to 72.9% by 2019 (
P
value for linear trend, <0.001). Among adults with BP above goal, the age-adjusted proportion who did not receive antihypertensive treatment increased throughout the decade from 18.8% to 21.6%, and the age-adjusted proportion who received ≥3 antihypertensive medications decreased from 41.8% to 36.3%. Prescriptions for first-line antihypertensive agents also decreased.

CONCLUSIONS:

Among adults with CKD treated in the Veterans Health Administration, the proportion with controlled BP declined between 2011 and 2015 followed by a modest increase, coinciding with fewer prescriptions for antihypertensive medications.
Long‐Term Stability of Patients Undergoing Endovascular Parent Artery Occlusion of Their Intracranial Artery
Authors: Koizumi Satoshi , Shojima Masaaki, , Ota Takahiro , Dofuku Shogo , Miyawaki Satoru , Kiyofuji Satoshi , Maeda Keiichiro , Ochi Takashi , Ito Akihiro , Hidaka Yukihiro , Oya Soichi , Saito Akira , Yoshikawa Gakushi , Yanai Kei , Inoue Tomohiro , Tsunoda Sho , Hoya Katsumi , Saito Nobuhito
Published: September 2023

Background

Although endovascular parent artery occlusion (PAO) of the intracranial artery is a well‐established treatment option, the long‐term stability of cerebral blood flow remains a concern. This study aimed to evaluate the long‐term clinical and radiological outcomes of patients who underwent PAO.

Methods

The patients who underwent endovascular PAO of their internal carotid or vertebral artery (VA) between April 2011 and March 2022 were included in this observational study. Information about patient characteristics, details of the endovascular treatment, and clinical and radiological follow‐up were collected.

Results

The study included a total of 104 cases (average age, 52.9±12.6 years old; men, 73 [70.2%] cases; 95 [91.3%] VA PAO cases) from 8 centers. Most cases were performed in an emergency condition, such as ruptured VA dissecting aneurysm (73 cases [70.2%]). PAO was successful in all cases. Early stroke (within 30 days) occurred in 33 (31.7%) cases (31 cases in VA PAO and 2 cases in internal carotid PAO) with ischemic stroke (29 cases) comprising the largest group. Clinical follow‐up over 1 month was available in 85 cases. During an average follow‐up period of 45.8±25.8 months, 1 case of VA PAO experienced a stroke without functional deterioration. Imaging follow‐up was performed in 75 cases. Recanalization of the occluded VA was observed in 2 cases. The remaining image change was contralateral VA stenosis after VA PAO. The incidence of clinical and radiological events was 1.2% and 1.1% per patient‐year, respectively.

Conclusion

Once the patients surpass the acute phase after PAO, their mid‐ to long‐term course was stable. The risk of late stroke or de novo aneurysm formation was lower than expected in the literature, and the direct comparison to novel reconstructive techniques is warranted in future studies. Clinical Trial Registration information:
https://www.umin.ac.jp/ctr/index.html
, trial ID: UMIN000045160.
The Abolition and Retention of Life Without Parole in Europe: A Comparative and Historical Perspective
Authors: Jouet Mugambi
Published: September 2023

Life without parole is increasingly recognised as another death penalty in dooming prisoners to die behind bars. On the tenth anniversary of the ECtHR’s landmark Vinter decision, abolitionism and retentionism characterise its state in Europe. In abolishing irreducible life sentences, Vinter crystallised a long-term evolution in prisoners’ rights since the Enlightenment. Meanwhile, enduring animosity towards prisoners has led to their rights repeatedly becoming the stage for wider debates concerning the legitimacy of European institutions. The United Kingdom’s threats to leave the ECtHR notably enabled it to exempt itself from Vinter. Still, the European project retains numerous supporters, which helps explain why the abolition of life without parole is making progress in continental Europe, as compared to the United States, Canada, Australia, and New Zealand. Ultimately, the article demonstrates that prisoners’ rights are both a microcosm of broader questions regarding European integration and a benchmark of human dignity’s historical evolution.
Serving Chinese adolescents in the digital age: A grand challenge for social work
Authors: Liu Weidi , Liu Susu , Ouyang Zheng
Published: September 2023

In this article, a total of 22 social workers in Mainland China were interviewed to explore the effectiveness and challenges of providing services to adolescents using digital tools. By addressing the problems like permeable boundaries, perfunctory efforts, threats to implementation fidelity, and inefficient service delivery, we accordingly propose pragmatic recommendations to enhance digital social work practice.
The Entrepreneurial Habitus of Zimbabweans in South Africa
Authors: Shingirai Nyakabawu
Published: September 2023

This article argues that individuals’ internalised frameworks, shaped by Bourdieu’s concept of habitus, play a crucial role in their ability to conceive entrepreneurial possibilities and to recognise opportunities. To explore this argument, interviews were conducted with Zimbabwean entrepreneurs residing in of Cape Town, South Africa. The participants exhibited diverse habituated experiences including culinary preferences, work backgrounds and family histories. The article contends that these habitual dispositions, whether conscious or unconscious, significantly influenced their decision to engage in entrepreneurship within the South African context.
Mapping the Indigenous Postcolonial Possibilities of Teacher Preparation
Authors: Lees Anna , Ryan Ann Marie , Muñoz Marissa , Tocci Charles
Published: September 2023

In this article, a team of teacher educators collectively think through the many possibilities of how concepts such as decolonization, abolition, and fugitivity intersect with and are taken up by teacher education programs. To do so, we undertook a critical interpretive synthesis of scholarly literature spanning 2000 to 2020 to locate, examine, and organize existing examples of teacher education programs that work to transgress hegemonic colonial models of education. We revisit de Oliveira Andreotti et al.’s social cartography as a framework for comparing the theoretical foundations and social implications of each teacher education program.
Affective Responses to Counter-Attitudinal Testimonials Drive Persuasive Effects: The Case of Physician-Assisted Suicide
Authors: Watts Judy , Slater Michael D. , Moyer-Gusé Emily
Published: September 2023

Overtly persuasive narratives such as testimonials pose significant challenges for theories of narrative persuasion. Such theories argue that overt persuasive intent diminishes entertainment and entertaining narratives reduce counterarguing. We propose that testimonial narratives instead have persuasive advantages through their ability to arouse message-consistent emotions and reduce affective reactance to the messages. Participants ( n = 1478) were randomly assigned to read a testimonial narrative or a non-narrative article about physician-assisted suicide. Articles were perceived as highly persuasive and low in entertainment intent; the testimonial was higher than the non-narrative in perceived eudaimonic intent. As predicted, testimonials reduced counterarguing via increased meaningful affect and decreased affective reactance to the message. Interaction tests showed that these effects were stronger in counterattitudinal participants. Theoretical implications for understanding the effects of testimonial narratives, particularly when the narratives are eudaimonic, are discussed, as are innovations for measuring counterarguing and perceived message intent.
A Classification System to Guide Treatment Needs for Juveniles Who Have Engaged in Abusive Sexual Behavior
Authors: Beltrani Amanda , Kang Tamara , Lee Austin , Mcgrath Robert E. , Prentky Robert A.
Published: September 2023

Developing an empirically derived classification system that accounts for the heterogeneity of youth could benefit the court, probation officers, and clinicians in making informed management and treatment decisions. This study used a latent class analysis to examine histories and treatment needs patterns among 561 youths who engaged in problematic sexual behavior (PSB) from five U.S. states. Three classes emerged and included: (a) low treatment need (LTN) youth without dysfunctional histories, (b) high transgressions and treatment needs (HTTN) youth with histories of conduct problems, and (c) abuse reactive (AR) youth with histories of maltreatment. Over one year, the LTN group had the lowest levels of treatment needs, the HTTN group had the highest, and the AR group had lower sexual and socioecological but higher general behavior treatment needs. Findings from this study can assist in allocating resources and help guide the individualization of interventions for youth with PSB.
‘They make it easier to learn and cope’: The views of adolescents with speech, language and communication needs on attending a flexible learning programme
Authors: Leitão Suze , Jackson Emily , Kippin Natalie R , Glisson Laura , Tomlin Toni , Boyes Mark
Published: September 2023

Flexible learning programmes (FLPs) and similar alternative education initiatives are designed to meet the diversity of needs of young people who have become disengaged from mainstream education. There is emerging evidence of the high prevalence of speech, language and communication needs (SLCN) and language disorders amongst students attending FLPs. This highlights the importance of understanding the views of these young people growing up in challenging psychosocial contexts about their experiences of schooling. We report on the perspectives of 45 students (aged 12–18 years) who had identified SLCN and who attended an FLP. We wanted to understand what they found valuable (and not) in their current FLP and how this compared to their previous schooling experience. The majority of students responded positively when asked about their current high school. Key factors identified via qualitative content analysis included how the FLP class content and environment were suited to them, the responsiveness of staff to their learning and personal needs, how their autonomy was respected, and the positive peer relationships they had developed in the FLP. Understanding these factors will support the design and implementation of educational programmes that foster improved engagement with, and achievement within, both FLPs and mainstream schools.
The Experience of Active Representation in South Korea: How Marriage-Based Immigrant Public Servants Represent Their Clients
Authors: Choi Junghwa , Robinson Scott
Published: September 2023

A long research tradition has argued that representative public servants regularly advocate for the interests of clients like themselves—whether similarity is based on race, ethnicity, or gender. This article broadens the representative bureaucracy literature to explore a different basis for advocacy (marriage-based immigrant status) using unique qualitative data. To explore the experience of representation from the perspective of public servants, we conducted semi-structured interviews with marriage-based immigrant public servants in South Korea in 2017. Our results indicate that while marriage-based immigrant public servants actively attempt to address the needs of the marriage-based immigrant population, advocacy is often a learned behavior rather than the reason public servants sought their positions. It is also observed that their efforts to represent the marriage-based immigrant population are heavily limited by institutional factors of South Korea such as insecure job status and the lack of a critical mass of marriage-based immigrant public servants.
The pandemic as portal: Terror, transition and transformation
Authors: von Sommaruga Howard Teresa
Published: September 2023

This paper was written as the keynote address for the Annual Study Day of the Irish Group Analytic Society in November 2021. Writing it gave me an opportunity to gather my thoughts about not only the deep fear and constraint I had lived with personally over the previous 18 months, but also challenged me to rethink the social consequences of the inequalities that are built into our world.

I start from a position that assumes that the political and economic context in which we live influences not only our thinking and emotional life, but also our practice. As Foulkes explained many times, and he had life experiences to confirm this theory, ‘the individual is social to the core’ (1948). This means that I see a dialectical association between the external world in which I live and my internal sense-making psychic world. I notice that this link often gets missed.

I suggest that what we might be taking through the portal of the pandemic will depend on our economic system, its connection to political structures, and how these contextual often ‘out-of-sight’ forces impact our lives concretely and psychically while framing our capacity to think about the situation we find ourselves in.

Even though it is difficult to know what the long-term effects might be, I have found exploring these dilemmas in the social context of an on-going Larger Group gives me a form of comfort that enables me to expand my thinking and remain conscious in the face of unrelenting and frightening socio-political change.

I understand the Larger Group as a place where it is possible to witness these social and political forces as they manifest themselves in the group and to explore how they connect to those that arise from my family recognizing that it is not a large Small Group but, from de Maré’s perspective, operates as an as-if society that generates different meanings. As de Maré often said,‘It is important to talk’. I have learned that talking with others in these settings, helps me to break through into new language to escribe my experience.
Find the Wifi, free the watchdog: Sub-Saharan African smartphone users’ attitudes about accountability journalism
Authors: Martin Jason A.
Published: September 2023

This study explores the association of mobile media and citizens’ attitudes surrounding watchdog journalism in sub-Saharan Africa. Face-to-face survey interviews with 2,589 smartphone users were conducted in six sub-Saharan African nations that have seen rapid expansion of smartphone penetration in recent years. The use of mobile phones for news-seeking predicted positive attitudes about accountability journalism in democratic governance. Results contribute to more nuanced discussion about mobile media and news habits in an understudied region.
Perceived Quality of Life in Intensive Care Medicine Physicians: A French National Survey
Authors: Terzi Nicolas , Fournier Alicia , Lesieur Olivier , Chappé Julien , Annane Djillali , Chagnon Jean-Luc , Thévenin Didier , Misset Benoit , Diehl Jean-Luc , Touati Samia , Outin Hervé , Dauger Stéphane , Sement Arnaud , Drault Jean-Noël , Rigaud Jean-Philippe , Laurent Alexandra ,   For the French Trade Union of Intensive Care Physicians
Published: September 2023

Purpose: There is a growing interest in the quality of work life (QWL) of healthcare professionals and staff well-being. We decided to measure the perceived QWL of ICU physicians and the factors that could influence their perception. Methods: We performed a survey coordinated and executed by the French Trade Union of Intensive Care Physicians (SMR). QWL was assessed using the French version of the Work-Related Quality of Life (WRQoL) scale, perceived stress using the French version of 10 item-Perceived Stress Scale (PSS-10) and group functioning using the French version of the Reflexivity Scale, the Social Support at Work Questionnaire (QSSP-P). Results: 308 French-speaking ICU physicians participated. 40% perceived low WRQoL, mainly due to low general well-being, low satisfaction with working conditions and low possibility of managing the articulation between their private and professional lives. Decreased QWL was associated with being a woman (p = .002), having children (p = .022) and enduring many monthly shifts (p = .022). Conclusions: This work highlights the fact that ICU physicians feel a significant imbalance between the demands of their profession and the resources at their disposal. Communication and exchanges within a team and quality of social support appear to be positive elements to maintain and/or develop within our structures.