bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional characterization of α-Gal producing lactic acid bacteria with potential probiotic properties
Authors: Bamgbose Timothy , Alberdi Pilar , Abdullahi Isa O. , Inabo Helen I. , Bello Mohammed , Sinha Swati , Anvikar Anupkumar R. , Mateos-Hernandez Lourdes , Torres-Maravilla Edgar , Bermúdez-Humarán Luis G. , Cabezas-Cruz Alejandro , de la Fuente Jose
Published: May 2022

The possibility of exploiting the human immune response to glycan α-Gal for the control of multiple infectious diseases has been the objective of recent investigations. In this field of research, the strain ofEscherichia coliO86:B7 has been at the forefront, but this Gram-negative microorganism presents a safety concern and therefore cannot be considered as a probiotic. To address this challenge, this study explored the identification of novel lactic acid bacteria with a safe history of use, producing α-Gal and having probiotic potential. The lactic acid bacteria were isolated from different traditionally fermented foods (kununn-zaki,kindirmo, andpulque) and were screened for the production of α-Gal and some specific probiotic potential indicators. The results showed that Ten (10) out of forty (40) [25%] of the tested lactic acid bacteria (LAB) produced α-Gal and were identified asLimosilactobacillus fermentum, Levilactobacillus brevis, Agrilactobacillus composti, Lacticaseibacillus paracasei,Leuconostoc mesenteroidesandWeissella confusa. Four (4) LAB strains with highest levels of α-Gal were further selected for in vivo study using a mouse model (α1,3GT KO mice) to elucidate the immunological response to α-Gal. The level of anti-α-Gal IgG observed were not significant while the level of anti-α-Gal IgM was lower in comparison to the level elicited byE.coliO86:B7. We concluded that the lactic acid bacteria in this study producing α-Gal have potential probiotic capacity and can be further explored in α-Gal-focused research for both the prevention and treatment of various infectious diseases and probiotic development.
Thiazol-2-ylidenes as N-Heterocyclic carbene ligands with enhanced electrophilicity for transition metal catalysis
Authors: Zhang Jin , Li Tao , Li Xiangyang , Lv Anqi , Li Xue , Wang Zheng , Wang Ruihong , Ma Yangmin , Fang Ran , Szostak Roman , Szostak Michal
Published: May 2022

Over the last 20 years, N-heterocyclic carbenes (NHCs) have emerged as a dominant direction in ligand development in transition metal catalysis. In particular, strong σ-donation in combination with tunable steric environment make NHCs to be among the most common ligands used for C–C and C–heteroatom bond formation. Herein, we report the study on steric and electronic properties of thiazol-2-ylidenes. We demonstrate that the thiazole heterocycle and enhanced π-electrophilicity result in a class of highly active carbene ligands for electrophilic cyclization reactions to form valuable oxazoline heterocycles. The evaluation of steric, electron-donating and π-accepting properties as well as structural characterization and coordination chemistry is presented. This mode of catalysis can be applied to late-stage drug functionalization to furnish attractive building blocks for medicinal chemistry. Considering the key role of N-heterocyclic ligands, we anticipate that N-aryl thiazol-2-ylidenes will be of broad interest as ligands in modern chemical synthesis.
Selective hydrogenation of graphene on Ir(111): an X-ray standing wave study
Authors: Kastorp Claus F. P. , Duncan David A. , Jørgensen Anders L. , Scheffler Martha , Thrower John D. , Lee Tien-Lin , Hornekær Liv , Balog Richard
Published: May 2022

Graphene on Ir(111) was hydrogenated selectively in the HCP and FCC regions by controlling the substrate temperature during exposure. Hydrogenated carbon in these areas both form ordered clusters, but are found to contribute to different components.
Pre-Dewar structure modulates protonated azaindole photodynamics
Authors: Mansour Ritam , Mukherjee Saikat , Pinheiro Max , Noble Jennifer A. , Jouvet Christophe , Barbatti Mario
Published: May 2022

Nonadiabatic surface hopping simulations demonstrate that the lifetime of the S3 state of protonated 7-azaindole is much longer than that of protonated 6-azaindole due to a puckered pre-Dewar structure in the S3 minimum of the 7-isomer.
NMR studies of inclusion complexes: naphthalene and natural cyclodextrins
Authors: Jopa Sylwia , Wójcik Jacek , Ejchart Andrzej , Nowakowski Michał
Published: May 2022

NP/αCD displays well-defined 1 : 2 stoichiometry. For naphthalene and both bigger CDs, three different species coexist in solution, namely complexes with 1 : 1, 2 : 1, and 2 : 2 stoichiometries.
Ruthenium containing molecular electrocatalyst on glassy carbon for electrochemical water splitting
Authors: Li Lin , Das Biswanath , Rahaman Ahibur , Shatskiy Andrey , Ye Fei , Cheng Peihong , Yuan Chunze , Yang Zhiqi , Verho Oscar , Kärkäs Markus D. , Dutta Joydeep , Weng Tsu-Chien , Åkermark Björn
Published: May 2022

Immobilizing ruthenium containing molecular electrocatalyst onto glassy carbon surface through bipyridine linkers and MWCNTs for efficient water oxidation.
Pyrolytic lignin: a promising biorefinery feedstock for the production of fuels and valuable chemicals
Authors: Figueirêdo M. B. , Hita I. , Deuss P. J. , Venderbosch R. H. , Heeres H. J.
Published: May 2022

Pyrolysis oil from lignocellulosic biomass can be fractionated into a lignin and sugar fraction. We here provide a review on the structure, properties, depolymerisation strategies and applications for pyrolytic lignin in the framework of a biorefinery.
Influence of storage temperature on the stability of heat treated phycocyanin-λ-carrageenan complexes in liquid formulations
Authors: Buecker Stephan , Grossmann Lutz , Loeffler Myriam , Leeb Elena , Weiss Jochen
Published: May 2022

The protein-chromophore interactions of phycocyanin are prone to changes in environmental conditions. Loss of these interactions leads to disappearance of the color. After stabilization with λ-carrageenan, phycocyanin can be stabilized over 28 days.
A hybrid method combining discharge-assisted laser induced breakdown spectroscopy with wavelet transform for trace elemental analysis in liquid targets
Authors: Xu Boping , Liu Simeng , Lei Bingying , Liu Yinghua , Zhang Wenfu , Tang Jie , Wang Yishan , Zhao Wei , Duan Yixiang
Published: May 2022

A hybrid method combining discharge-assisted laser-induced breakdown spectroscopy (D-LIBS) with wavelet transform represents a highly promising detection technology for the quantitative determination of trace elements in liquids.
Smartphone-based digitized recognition of As3+ along with its effectual mitigation in water using a benzothiazole-functionalized molecular scaffold
Authors: Nag Somrita , Mondal Amita , Hirani Harish , Banerjee Priyabrata
Published: May 2022

The chromogenic chemosensor ABH is capable to recognize and mitigate jeopardized As3+ and sequentially detect toxic F− by mimicking a logic gate ensemble. Arsenic Sensing Kit and RGB enable smartphone-based device have been explored.
Engineered protein–iron oxide hybrid biomaterial for MRI-traceable drug encapsulation
Authors: Hill Lindsay K. , Britton Dustin , Jihad Teeba , Punia Kamia , Xie Xuan , Delgado-Fukushima Erika , Liu Che Fu , Mishkit Orin , Liu Chengliang , Hu Chunhua , Meleties Michael , Renfrew P. Douglas , Bonneau Richard , Wadghiri Youssef Z. , Montclare Jin Kim
Published: May 2022

This protein–iron oxide hybrid biomaterial aims to integrate the drug encapsulating potential of a coiled-coil protein with peptide-driven iron oxide biomineralization to serve as drug-carrying, MRI-detectable mesofiber.
A two-dimensional thin Co-MOF nanosheet as a nanozyme with high oxidase-like activity for GSH detection
Authors: Han Miaomiao , Ren Mengzhen , Li Zhaohui , Qu Lingbo , Yu Lanlan
Published: May 2022

A two-dimensional thin Co-MOF (ZIF-67) nanosheet with high oxidase-like activity was applied for sensitive visual GSH detection.
Two 5-(thiophene-2-yl)oxazole derived “turn on” fluorescence chemosensors for detection of Ga3+ and practical applications
Authors: Liu Yuanying , Wang Haitao , Guo Xiaochuan , Xing Yujing , Wei Kehui , Kang Mingyi , Yang Xiaofeng , Pei Meishan , Zhang Guangyou
Published: May 2022

Sensors L1 and L2 show highly selective responses to Ga3+ even over Al3+ and In3+ with effective fluorescence enhancement.
Magnetically recyclable core–shell MOF nanoparticles of Fe3O4@PDA@UIO-66-NH2 grafted by organic acids for intensified cationic dye adsorption
Authors: Fu Yujia , Xu Yue , Lou Boxuan , Qin Xiaolan , Zhang Leilei , Yuan Haikuan , Zhang Lijuan , Zhang Yan , Lu Jie
Published: May 2022

The adsorption mechanism towards MB by the two adsorbents is mainly due to IE at lower solution pH and EA at higher solution pH than their pHpzc.
Direct synthesis of highly strained bifunctionalized 2H-thiete 1,1-dioxides
Authors: Sun Simin , Zhang Mengyao , Xu Jiaxi
Published: May 2022

Various bifunctionalized dialkyl 2H-thiete-2,3-dicarboxylate 1,1-dioxides are directly and convergently synthesized from readily available sulfonyl chlorides and dialkyl acetylenedicarboxylates via the pyridine-mediated [2 + 2] annulation.
Chemical and electrochemical synthesis of cobalt hydroxides: selective phase transformation and application to distinct electrocatalytic reactions
Authors: Park Joon Yong , Kim Ha Young , Kim Yong-Il , Jo So Yeong , Abbas Syed Asad , Seo Dongho , Ma Ahyeon , Nam Ki Min
Published: May 2022

Electrochemical and chemical phase transformations of α-Co(OH)2 into various other cobalt hydroxides were performed, and their structures were characterized to discern the correlation between electrocatalytic activity and crystal structure.
A molecularly imprinted antibiotic receptor on magnetic nanotubes for the detection and removal of environmental oxytetracycline
Authors: Wang Jixiang , Li Xiaolei , Zhang Rong , Fu Bingjie , Chen Mingcan , Ye Mengxue , Liu Wanyu , Xu Jingjing , Pan Guoqing , Zhang Hongbo
Published: May 2022

The detection and elimination of antibiotic contaminants, such as oxytetracycline (OTC), a broad-spectrum tetracycline antibiotic, would be of help in efficient environmental monitoring, agriculture and food safety tests.
Highly sensitive filterless near-infrared wavelength sensors with two self-driven MLG/Ge heterojunctions
Authors: Zhao Yao-Zu , Fu Can , Liang Feng-Xia , Xiao Yu-Tian , Li Jing-Yue , Liu Ming-Ming , Wu Di , Luo Lin-Bao
Published: May 2022

A schematic diagram of the device principle of a wavelength sensor consisting of two horizontally stacked MLG/Ge heterojunctions and the wavelength-dependent photocurrent ratio at different thicknesses of PD1.
RIP1 post-translational modifications
Authors: Varfolomeev Eugene , Vucic Domagoj
Published: May 2022

Receptor interacting protein 1 (RIP1) kinase is a critical regulator of inflammation and cell death signaling, and plays a crucial role in maintaining immune responses and proper tissue homeostasis. Mounting evidence argues for the importance of RIP1 post-translational modifications in control of its function. Ubiquitination by E3 ligases, such as inhibitors of apoptosis (IAP) proteins and LUBAC, as well as the reversal of these modifications by deubiquitinating enzymes, such as A20 and CYLD, can greatly influence RIP1 mediated signaling. In addition, cleavage by caspase-8, RIP1 autophosphorylation, and phosphorylation by a number of signaling kinases can greatly impact cellular fate. Disruption of the tightly regulated RIP1 modifications can lead to signaling disbalance in TNF and/or TLR controlled and other inflammatory pathways, and result in severe human pathologies. This review will focus on RIP1 and its many modifications with an emphasis on ubiquitination, phosphorylation, and cleavage, and their functional impact on the RIP1's role in signaling pathways.
Traffic forecasting with missing data via low rank dynamic mode decomposition of tensor
Authors: Zhang Xinyu , Zhang Yong , Wei Xiulan , Hu Yongli , Yin Baocai
Published: May 2022

Traffic forecasting is an important part in realising intelligent traffic management, which helps traffic controllers and travellers make effective decisions. However, traffic forecasting accuracy is often affected by missing traffic data due to hardware and software failure. Therefore, accurate prediction based on incomplete traffic data is an important problem as well as a challenge. Though many approaches recover the missing values before prediction, the errors from the data‐filling step are likely to cause additional bias to the prediction result. Besides, this tactic is difficult to guarantee the timeliness and may impede real‐time prediction. In this case, a traffic forecasting model is proposed to directly predict traffic data with missing values. This model develops tensor formed dynamic mode decomposition, recording the dynamic information of traffic data into a state transition tensor. In addition, the model takes low rank property of the dynamic tensor and the similarity of temporal variation trend into consideration. In order to verify the effectiveness and the robustness of the proposed model, experiments were performed on two real‐world time series datasets. The results demonstrate that the model achieves better performance on forecasting than other baseline approaches under the impact of missing data.
Sequence of operations for real‐time control of microgrids and networked microgrids
Authors: Sheikholeslami Mehrdad , Yan Lei , Shahidehpour Mohammad , Gurung Niroj , Zheng Honghao , Vukojevic Aleksandar , Paaso Aleksi , Li Zuyi
Published: May 2022

Microgrids (MGs) provide a potential solution to accommodating renewable and distributed energy resources (DERs). MGs and the networked form of MGs, that is, networked MGs or NMGs, have received significant attention in the past two decades. However, several details that need to be considered for the practical operations of MGs and NMGs are often neglected in the literature. First, there is a need for a step‐by‐step sequence of operations (SOO) that clearly defines the procedures for changing the operation modes of MGs and NMGs for their reliable and resilient operation. Second, there is a need to develop a new control strategy for power exchange between networked MGs to ensure the information privacy and respect the electrical boundary of each MG. Third, there is a need for developing the model of MGs and NMGs in a real‐time simulator to safely evaluate the performance of the microgrid master controller (MMC) in making real‐time decisions and following the SOO. This paper proposes solutions for these three requirements and presents results to evaluate the performance of the proposed solutions. The IIT Campus Microgrid (ICM) and Bronzeville Community Microgrid (BCM), as well as their networked form, are selected as the practical testbeds and are modelled in real‐time digital simulator (RTDS). The RTDS model is interfaced with the MMC for real‐time data exchange and the operation of the MMC is tested to illustrate the importance of SOO in the real‐time control of MGs and NMGs.
A quarter century of spectroscopic monitoring of the nearby M dwarf Gl 514
Authors: Damasso M. , Perger M. , Almenara J. M. , Nardiello D. , Pérez-Torres M. , Sozzetti A. , Hara N. C. , Quirrenbach A. , Bonfils X. , Zapatero Osorio M. R. , Astudillo-Defru N. , González Hernández J. I. , Suárez Mascareno A. , Amado P. J. , Forveille T. , Lillo-Box J. , Alibert Y. , Caballero J. A. , Cifuentes C. , Delfosse X. , Figueira P. , Galadí-Enríquez D. , Hatzes A. P. , Henning Th. , Kaminski A. , Mayor M. , Murgas F. , Montes D. , Pinamonti M. , Reiners A. , Ribas I. , Béjar V. J. S. , Schweitzer A. , Zechmeister M.
Published: May 2022

Context. Statistical analyses based on Kepler data show that most of the early-type M dwarfs host multi-planet systems consisting of Earth- to sub-Neptune-sized planets with orbital periods of up to ~250 days, and that at least one such planet is likely located within the habitable zone. M dwarfs are therefore primary targets to search for potentially habitable planets in the solar neighbourhood.

Aims. We investigated the presence of planetary companions around the nearby (7.6 pc) and bright (V = 9 mag) early-type M dwarf Gl 514, analysing 540 radial velocities collected over nearly 25 yr with the HIRES, HARPS, and CARMENES spectrographs.

Methods. The data are affected by time-correlated signals at the level of 2–3 m s−1 due to stellar activity, which we filtered out, testing three different models based on Gaussian process regression. As a sanity cross-check, we repeated the analyses using HARPS radial velocities extracted with three different algorithms. We used HIRES radial velocities and Hipparcos-Gaia astrometry to put constraints on the presence of long-period companions, and we analysed TESS photometric data.

Results. We find strong evidence that Gl 514 hosts a super-Earth on a likely eccentric orbit, residing in the conservative habitable zone for nearly 34% of its orbital period. The planet Gl 514b has minimum mass mb sin ib = 5.2 ± 0.9 M⊕, orbital period Pb = 140.43 ± 0.41 days, and eccentricity eb = 0.45−0.14+0.15. No evidence for transits is found in the TESS light curve. There is no evidence for a longer period companion in the radial velocities and, based on astrometry, we can rule out a ~0.2 MJup planet at a distance of ~3–10 astronomical units, and massive giant planets and brown dwarfs out to several tens of astronomical units. We discuss the possible presence of a second low-mass companion at a shorter distance from the host than Gl 514 b.

Conclusions. Gl 514 b represents an interesting science case for studying the habitability of planets on eccentric orbits. We advocate for additional spectroscopic follow-up to get more accurate and precise planetary parameters. Further follow-up is also needed to investigate the presence of additional planetary signals of less than 1 m s−1.
Richtig anleiten – Theorie-Praxis-Transfer in der Physiotherapieausbildung
Authors: Riese Marion
Published: May 2022

In physiopraxis-Ausgabe 1/20 erschien der Artikel „Schwachstelle praktische Ausbildung“, der Defizite in der praktischen Ausbildung betrachtet und vier Bereiche der Professionalisierung vorgestellt hat. In der Fortsetzung gibt Prof. Dr. Marion Riese Anregungen für die Vorgehensweise von Praxisanleiter-(inn)en und erklärt, wie man in Kliniken den Theorie-Praxis-Transfer bestmöglich gestaltet.
Wenn wenig viel hilft – Fallbeispiel chronischer Rückenschmerz
Authors: Richter Michael
Published: May 2022

Patienten mit persistierenden Beschwerden brauchen Handwerkszeug, mit dem sie ihre Beschwerden selbst beeinflussen können. So können sie langsam, aber sicher die Kontrolle über ihre Symptome zurückerlangen. Michael Richter stellt den Fall eines jungen Mannes mit Rücken-schmerzen vor, der so ähnlich immer wieder in Physiotherapiepraxen vorkommt.
Ein Leben unter Spannung – Eine Verbrennungsgeschichte
Authors: Frank Petra
Published: May 2022

Mit 18 Jahren erleidet Annika Ladewig auf einem Festival lebensbedrohliche Brandverletzungen mit starker Narbenbildung. Seit 2018 ist die selbstbewusste junge Frau als Physiotherapeutin an der Moritz-Klinik im thüringischen Bad Klosterlausnitz tätig. Hier behandelt sie heute selbst Brandverletzte. Ihre besondere Superkraft: anderen Mut machen.
Praxisleitung mit Hirn – Psychisches Wohlbefinden am Arbeitsplatz
Authors: Kranz Florence
Published: May 2022

Wünschen Sie sich auch Mitarbeitende, die sich bei der Arbeit wohlfühlen und jeden Tag engagiert mit ihren Patient(inn)en nach den bestmöglichen Lösungen suchen? Als Praxisleitung können Sie jede Menge tun, um das Wohlbefinden Ihrer Angestellten zu stärken. Werfen Sie mit uns einen Blick auf die Forschung und erfolgreiche Praxisbeispiele.
Lesend Fortbildungspunkte sammeln – Continuing Physiotherapy Education
Authors: Zalpour Christoff
Published: May 2022

Wer eine Physiotherapiezeitschrift von Thieme abonniert hat, kann damit künftig Fortbildungspunkte sammeln. Regel-mäßig wird es sogenannte CPTE-Artikel samt Fragen geben, die man online beantworten kann. Der Artikel erzählt den Weg der Forschungsgruppe, die sich mit Continuing Physiotherapy Education beschäftigt.
Intrafamiliäre Variabilität des Phänotyps der 5q-assoziierten spinalen Muskelatrophie am Beispiel von 2 Geschwistern
Authors: Becker Benedikt , Cordts Isabell , Deschauer Marcus
Published: May 2022

Die 5q-assoziierte spinale Muskelatrophie (SMA) ist eine autosomal-rezessiv vererbte Erkrankung, die durch biallelische Defekte im SMN1-Gen (survival of motor neuron 1) auf Chromosom 5q verursacht wird. Der Gendefekt bewirkt einen fortschreitenden Untergang motorischer Vorderhornzellen im Rückenmark, was zu progredienten atrophen Paresen führt. Manifestationsalter und Schweregrad können sehr unterschiedlich sein. Die Anzahl der SMN2-Genkopien ist der entscheidende Modifier, es werden jedoch auch andere Faktoren vermutet. Anhand zweier Brüder mit 5q-assoziierter SMA soll gezeigt werden, dass trotz gleicher SMN2-Genkopienzahl erhebliche Unterschiede im Manifestationsalter und klinischen Phänotyp vorliegen können. Dies hat Implikationen für die genetische Beratung von gesunden Geschwistern von SMA-Patienten, da es zeigt, dass auch ältere Geschwister von Betroffenen ein Erkrankungsrisiko haben. Eine genetische Testung von Geschwistern kann nicht nur die Frage der Anlageträgerschaft beantworten, sondern hat auch einen prädiktiven Charakter. Dies ist aufgrund der seit einigen Jahren verfügbaren Therapieoptionen der SMA, deren Wirksamkeit bei frühem Therapiebeginn besonders hoch ist, von besonderer Bedeutung.
Rehabilitative Kompetenz im Akutbereich verankern: die
rehabilitationsbeauftragte Ärztin/der rehabilitationsbeauftragte
Arzt im Krankenhaus (Kurzfassung)
Authors: Beyer Joachim , Best Norman , Glaesener Jean Jacques , Kasprick Lysann , Reißhauer Anett , Liebl Max Emanuel
Published: May 2022

Die Übergänge aus der Krankenhausbehandlung in die nachfolgenden
Versorgungssysteme haben sich bereits durch das eingeführte
Entlassmanagement verbessert. Jedoch gewährleisten weder die
Krankenhausbehandlung selbst noch das Entlassmanagement derzeit die volle
Ausschöpfung vorhandener Rehabilitationspotentiale.  In den
Akutkliniken fehlt im ärztlichen Bereich eine ausreichende
rehabilitationsmedizinische Kompetenz, und zwar sowohl im Hinblick auf die
Durchführung der stationären Behandlung mit rehabilitativer
Zielsetzung (vgl. § 39 SGB V, § 43 SGB IX) als auch im Hinblick
auf die rehabilitativ ausgerichtete Weiterversorgung einschließlich der
zeitnahen Vermittlung in eine bedarfsgerechte Rehabilitationseinrichtung.
 Rehabilitationsmedizinische Kompetenz innerhalb von
Krankenhäusern kann über das Einführen
einer/eines ärztlichen Reha-Beauftragten mit klaren
Qualifikationsvorgaben erreicht werden.
Die COVID-19-Pandemie und psychische Störungen bei Minderjährigen
Authors: Kölch Michael
Published: May 2022

Die psychosozialen Folgen der COVID-Pandemie auf Minderjährige müssen differenziert betrachtet werden: Belastungen bedeuten nicht, dass auch eine psychische Störung besteht. Nicht alle Kinder sind gleichermaßen gefährdet für psychosoziale Folgen. Bereits vor der Pandemie bekannte Risikofaktoren sind während und nach der Pandemie gültig. Bei Kindern, die bereits an einer psychischen Störung leiden, kann die Pandemie zur Verschlechterung der Symptomatik oder der Teilhabe führen. Schwachstellen in der Versorgung wurden deutlich. Andererseits untersuchte eine Vielzahl an Studien die psychischen Auswirkungen der Pandemie. Langzeitstudien und auf Risikogruppen ausgerichtete Studien sind zukünftig notwendig. Die Pandemie unterstreicht, dass die psychische Gesundheit von Kindern eines der wichtigsten Gesundheitsthemen in Deutschland ist. Kurzfristig bedarf es der Flexibilisierung in der Versorgung, um Mehrbedarfe in der Versorgung zu begegnen. Langfristig ist es notwendig, in der Versorgung Strukturen einzuführen, die eine risikoadaptierte Prävention, Behandlung und Teilhabeunterstützung ermöglichen. Innovative Versorgungsstrukturen müssten auch rechtskreisübergreifend gestaltet sein.
Utility of a canine TSH assay for diagnosis and monitoring of feline hyperthyroidism
Authors: Urbanschitz Tobias , Burgener Iwan A. , Zeugswetter Florian K.
Published: May 2022

Objective This retrospective study was initiated to evaluate the utility of TSH measurements using a common canine TSH assay to diagnose and monitor feline hyperthyroidism after radioiodine or thyreostatic drug treatment.

Material and methods The electronic database of the University of Veterinary Medicine Vienna was searched for combined TSH and T4 measurements. 217 pairs of TSH and T4 from 136 cats with possible hyperthyroidism were assigned to group A (untreated; n = 24) and B (treated; n = 193). Measurements in group B were then subcategorized according to T4 concentrations (reference range 15–50 nmol/L): group B1 = elevated T4 (n = 46), group B2 = normal T4 (n = 84) and group B3 = decreased T4 (n = 63). Group B2 was further divided into cats with low normal (group B2a; n = 35), medium normal (group B2b; n = 29) and high normal (group B2c; n = 20) T4 concentrations.

Results TSH was detectable in 4 (17 %) of the 24 untreated cats (group A) and did not return to normal despite seemingly successful therapy in two. Increased TSH concentrations were observed in 3.6 % of the treated cats in group B2 and 2.9 %, 6.9 %, and 0 % in subgroups B2a, B2b and B2c, respectively. Forty-four percent of the treated cats with a decreased T4 (group B3) had an increased TSH concentration. TSH correlated with treatment length (r = 0.358, p = 0.004) and was significantly higher in cats treated for more than 3 months (p = 0.008).

Conclusion TSH was detectable in a significant number of untreated hyperthyroid cats and thus this parameter should not be used to definitively rule out feline hyperthyroidism. Furthermore, the very low prevalence of increased TSH concentrations in treated hyperthyroid cats with a normal T4 and cost benefit calculations do not support the routine measurement of TSH in these cats. The fact that TSH correlated with time since treatment start and 56 % of the cats with a decreased T4 had TSH concentrations within the reference limits, suggests delayed recovery of the pituitary thyrotrophs which might explain the low prevalence of subclinical hypothyroidism in the present study.

Clinical relevance TSH measurement in cats with suspected or treated hyperthyroidism using a canine assay lacks diagnostic sensitivity and can only complement therapeutic decision-making.
Point-of-Care Ultrasound in Neurology – Report of the EAN SPN/ESNCH/ERcNsono Neuro-POCUS Working Group
Authors: Valaikiene Jurgita , Schlachetzki Felix , Azevedo Elsa , Kaps Manfred , Lochner Piergiorgio , Katsanos Aristeidis H. , Walter Uwe , Baracchini Claudio , Bartels Eva , Školoudík David
Published: May 2022

In the last decade, ultrasound examination in neurology has been undergoing a significant expansion of its modalities. In parallel, there is an increasing demand for rapid and high-quality diagnostics in various acute diseases in the prehospital setting, the emergency room, intensive care unit, and during surgical or interventional procedures. Due to the growing need for rapid answers to clinical questions, there is particular demand for diagnostic ultrasound imaging. The Neuro-POCUS working group, a joint project by the European Academy of Neurology Scientific Panel Neurosonology, the European Society of Neurosonology and Cerebral Hemodynamics, and the European Reference Centers in Neurosonology (EAN SPN/ESNCH/ERcNsono Neuro-POCUS working group), was given the task of creating a concept for point-of-care ultrasound in neurology called “Neuro-POCUS”. We introduce here a new ultrasound examination concept called point-of-care ultrasound in neurology (Neuro-POCUS) designed to streamline conclusive imaging outside of the ultrasound center, directly at the bedside. The aim of this study is to encourage neurologists to add quick and disease-oriented Neuro-POCUS to accompany the patient in the critical phase as an adjunct not a substitution for computed tomography, magnetic resonance imaging, or standard comprehensive neurosonology examination. Another goal is to avoid unwanted complications during imaging-free periods, ultimately resulting in advantages for the patient.
The Antiobesity Effect and Safety of GLP-1 Receptor Agonist in
Overweight/Obese Patients Without Diabetes: A Systematic Review and
Meta-Analysis
Authors: Guo Xiaonan , Zhou Zhibo , Lyu Xiaorui , Xu Hanyuan , Zhu Huijuan , Pan Hui , Wang Linjie , Yang Hongbo , Gong Fengying
Published: May 2022

Aim To determine the antiobesity effect and safety of glucagon-like
peptide-1 receptor agonist (GLP-1RA) including liraglutide, exenatide and
semaglutide treatment in overweight/obese patients without diabetes. The
random-effect model was used to pool data extracted from included literatures.
The weighted mean difference (WMD), odds ratio and 95% confidence
interval (CI) were used to present the meta-analysis results (PROSPERO
registration number: CRD 42020173199). The sources of intertrial heterogeneity,
bias and the robustness of results were evaluated by subgroup analysis,
sensitivity analysis and regression analysis, respectively. A total of 24 RCTs
were recruited in the present analysis which included 5867 patients. The results
showed that the treatment of overweight/obese patients without diabetes
with GLP-1RAs including liraglutide, exenatide and semaglutide significantly
achieved greater weight loss than placebo [WMD=–5.39,
95% CI (–6.82, –3.96)] and metformin
[WMD=–5.46, 95% CI (–5.87, –5.05)]. The
subgroup analysis showed that semaglutide displayed the most obvious antiobesity
effect in terms of weight loss, the reduction of body mass index (BMI) and waist
circumference (WC). However, GLP-1RAs treatments had more gastrointestinal
adverse events (such as nausea and vomiting) than placebo and Met. The subgroup
analysis also represented that semaglutide displayed the lowest risk of
gastrointestinal adverse events among three kinds of GLP-1RAs. Our meta-analysis
demonstrated that GLP-1RA had a superior antiobesity effect than
placebo/Met in overweight/obese patients without diabetes in
terms of body weight, BMI, and WC, especially for semaglutide, which had more
obvious antiobesity effect and lower GI adverse events than liraglutide and
exenatide.
Assembly of Pyran-Fused Isoquinolines via Rhodium-Catalyzed Double Annulations of Methyl Benzimidates with Diazo Compounds
Authors: Wu Yinsong , Zhang Enshen , He Xinwei , Shang Yongjia , Duan Jiahui , Xu Keke
Published: May 2022

A variety of pyran-fused isoquinoline derivatives were prepared in moderate to good yields through the rhodium-catalyzed dual C–H functionalization/annulation of methyl benzimidates and diazo compounds. A one-pot procedure, broad substrate scope, diversified products, and mild reaction conditions make this transformation a powerful tool for the synthesis of fused heteroarenes. In addition, the synthetic application was extended by large-scale synthesis and late-stage functionalization via Pd-catalyzed Suzuki–Miyaura, Heck, and Sonogashira cross-coupling reactions. Furthermore, a photophysical survey reveals that the pyran-fused isoquinoline products exhibit fluorescence properties and show potential for exploring fluorescent material applications.
Cost Savings Without Increased Risk of Respiratory Hospitalization for Preterm Children after the 2014 Palivizumab Policy Update
Authors: Levin Jonathan C. , Beam Andrew L. , Fox Kathe P. , Hayden Lystra P.
Published: May 2022

Objectives Our objective was to compare rates of hospitalizations for respiratory illnesses in preterm and full-term (FT) children for 4 years before and after the 2014 update to the American Academy of Pediatrics (AAP) respiratory syncytial virus (RSV) immunoprophylaxis guidance, which restricted eligibility among infants born at 29 to 34 weeks in the first winter and all preterm infants in the second winter after neonatal discharge.

Study Design We conducted pre-post and interrupted time series analyses on claims data from a commercial national managed care plan. We compared the number of RSV and all respiratory hospital admissions in the first and second RSV seasons after neonatal discharge among a cohort of preterm children, regardless of palivizumab status, in the 4 years before and after the implementation of the 2014 palivizumab eligibility change. A FT group was included for reference.

Results The cohort included 821 early preterm (EP, <29 weeks), 4,790 moderate preterm (MP, 29–34 weeks), and 130,782 FT children. Palivizumab use after the policy update decreased among MP children in the first and second RSV seasons after neonatal discharge, without any change in the odds of hospitalization with RSV or respiratory illness. For the EP group, there was no change in the rate of palivizumab or the odds of hospitalization with RSV or respiratory illness after the policy update. For the FT group, there was a slight decrease in odds of hospitalization post-2014 after the policy update. The interrupted time series did not reveal any secular trends over time in hospitalization rates among preterm children. Following the policy change, there were cost savings for MP children in the first and second RSV seasons, when accounting for the cost of hospitalizations and the cost of palivizumab.

Conclusion Hospitalizations for RSV or respiratory illness did not increase, and cost savings were obtained after the implementation of the 2014 AAP palivizumab prophylaxis policy.

Key Points
Incidence of Traumatic Lumbar Punctures in Neonates and Infants
Authors: Sievänen Harri , Palmu Sauli , Kari Juho , Soukka Hanna , Lähteenmäki Päivi , Eskola Vesa
Published: May 2022

Objectives The objective of this study is to examine factors accounting for the incidence of traumatic lumbar puncture (TLP) in infants younger than 1 year old.

Study Design Retrospective analysis of cerebrospinal fluid (CSF) data from 1,240 neonatal (≤28 days) and 399 infant lumbar puncture (LP) procedures was conducted. Data from two successive LP procedures were obtained from 108 patients. Logistic regression analysis was used to assess factors accounting for the incidence of TLP in the second LP procedure. The following categorical variables were entered into the model: whether the first procedure was traumatic according to criteria of ≥500 and ≥10,000 erythrocytes/µL, whether the LP procedures were performed within a week, and whether the patient was neonatal at the first procedure.

Results The incidences of TLP were 42.9% in neonates and 22.5% in infants for the criterion of ≥500 erythrocytes/µL, and 16.6 and 10.3% for the criterion of ≥10,000 erythrocytes/µL. Compared with a nontraumatic first LP procedure, if the first procedure was traumatic according to the criterion of ≥10,000 erythrocytes/µL, the odds ratio (OR) of TLP in the second procedure was 5.86 (p = 0.006). Compared with a longer time, if the successive procedures were performed within a week, the OR of TLP was 9.06 (p < 0.0001) according to the criteria of ≥500 erythrocytes/µL and 3.34 (p = 0.045) according to the criteria of ≥10,000 erythrocytes/µL. If the patient was neonatal at the first procedure, the OR of TLP at the second puncture was 0.32 (p = 0.031) according to the criterion of ≥500 erythrocytes/µL.

Conclusion The incidence of TLP in neonates is twice as high as that in infants. Successive LP procedures performed within a week and a highly blood-contaminated CSF sample in the first procedure each multiplied the odds of TLP in the second procedure, whereas being a neonate at the time of the first procedure reduced the odds of TLP.

Key Points
Factors Influencing the Purchase Rate of Cartilage Conduction Hearing Aids
Authors: Nishimura Tadashi , Hosoi Hiroshi , Sugiuchi Tomoko , Matsumoto Nozomu , Nishiyama Takanori , Kenichi Takano , Sugimoto Satofumi , Yazama Hiroaki , Sato Takeshi , Komori Masahiro
Published: May 2022

Abstract Background Innovated hearing aids (HAs), termed cartilage conduction hearing aids (CC-HAs), show good performance in patients with closed ears and continuous otorrhea. However, factors other than the ear condition that influence the purchase rate of
CC-HAs remain unclear. Purpose To identify the factors that influence the purchase rate of CC-HAs. Research Design A correlational study. Study Sample A total of 249 patients were enrolled. Data Collection and Analysis The patients'
demographics, clinical characteristics, outcomes, and CC-HA transducer types were compared. The data were analyzed for six groups classified based on the ear condition. Results In the unilateral closed-ear group, the purchase cases were significantly younger than the nonpurchase
cases (p < 0.05). Regarding the outcomes in the bilateral closed-ear group, the purchase cases showed significantly better-aided thresholds at 0.25 and 0.5 kHz than the nonpurchase cases. No significant differences in the functional gains and speech recognition
scores were found between purchase and nonpurchase cases in all six groups. Regarding the transducer type, the continued-use rate of the simple transducer type was significantly lower in the bilateral chronic continuous otorrhea, bilateral open, and unilateral open groups. Conclusion In
the closed ears, no remarkable negative factors were found. Transducer type had a significant influence on the continued-use rate in the nonclosed ears including the ears with chronic continuous otorrhea, although the purchase rate of CC-HAs in the bilateral chronic continuous otorrhea group
was comparable to the closed ears.
Burnout in U.S. Audiologists
Authors: Zimmer Madison , Emanuel Diana C. , Reed Nicholas S.
Published: May 2022

Abstract Background Research on burnout in audiologists is limited, especially in the United States. Recent changes to the profession may have increased burnout. Purpose The purpose was to investigate burnout in the U.S. audiologists in diverse
work settings. Research Design This study used three surveys: demographics/workplace stressors, Maslach Burnout Inventory (MBI), and professional quality of life (ProQOL). Study Sample Participants were 149 U.S. audiologists. Participants were diverse regarding
experience, work setting, and location. Data Collection and Analysis The first survey provided demographics, perspectives on over-the-counter (OTC) hearing aids, stressors, and stress rating. The MBI assessed three dimensions of burnout: emotional exhaustion, depersonalization,
and personal accomplishment. The ProQOL assessed burnout, compassion fatigue, and compassion satisfaction. Analyses included descriptive and inferential statistics of quantitative data and thematic analysis of qualitative data. Results Audiologists had low burnout, low compassion
fatigue, and high compassion satisfaction. Experience was not related to stress rating; however, more experienced audiologists had greater compassion satisfaction and lower burnout, emotional exhaustion, and depersonalization compared with less experienced audiologists. Concern about OTC hearing
aids was associated with stress rating. Thematic analysis identified 11 stressors, with 50% of stressors classified under work duties, time, and patients. Conclusion The U.S. audiologists had low burnout rates. Burnout was greatest in less experienced audiologists. Stress was
not related to experience. Stressors included insufficient time to see patients, heavy caseload, time-consuming administrative tasks, pressure to sell hearing aids, and stressful interpersonal communication.
Standardization of the TEOAE Contralateral Suppression Test in Terms of Stimulus Intensity and Contralateral Noise Duration in Individuals with Normal Hearing
Authors: Celikgun Bahtiyar , Derinsu Ufuk
Published: May 2022

Abstract Background A standard method and parameter study were performed for the contralateral suppression test. Purpose Our study aimed to determine the contralateral transient-evoked otoacoustic emission (TEOAE) suppression test method and stimulus‐noise
parameters that have a standard procedure and will enable the efferent system to be easily evaluated in clinics. Research Design: This study was conducted in two parts with two different groups of participants as a within-subjects design. In the first part, the signal-to-noise
ratio at which maximum suppression obtained was investigated with 29 participants. In the second part, the optimal contralateral noise presentation method (in terms of noise-time or noise-sweep) was examined with 21 participants. Study Sample In the first part 29 young adults
aged between 18 and 32 (23.03 ± 2.84), 20 females and 9 males, and in the second part 21 young adults aged between 19 and 34 years (mean age: 23.71 ± 3.48 years), 16 females and 5 males, participated in the second part. All participants had normal
hearing. Data Collection and Analysis To obtain maximum OAE suppression, different parameters were tested with the Otodynamics ILO292-II OAE device at both parts of the study in a double-walled audiometric test booths. Multirepeated analysis of variance, pairwise comparison,
Friedman test, and Wilcoxon signed-rank tests were used for statistical analysis. Results In the first part, maximum suppression was achieved at 65 dB peSPL (decibel peak-equivalent sound pressure level) TEOAE stimulus and 65 dB SPL broadband noise. In the second
part, maximum suppression was obtained in noise-time method with 30 seconds “duration.” Conclusions To provide standardization in clinics, it can be recommended that the contralateral suppression of OAEs was measured at 65 dB peSPL TEOAE stimulus and
65 dB SPL broadband noise in the linear stimulation mode with Otodynamics ILO 292-II double-probe OAE device. To obtain maximum suppression, the noise-time method with 30 seconds duration can be used.
Dual-Energy CT in the Pancreas
Authors: Mroueh Nayla , Cao Jinjin , Kambadakone Avinash
Published: May 2022

Dual-energy computed tomography (DECT) is an evolving imaging technology that is gaining popularity, particularly in different abdominopelvic applications. Essentially, DECT uses two energy spectra simultaneously to acquire CT attenuation data which is used to distinguish among structures with different tissue composition. The wide variety of reconstructed image data sets makes DECT especially attractive in pancreatic imaging. This article reviews the current literature on DECT as it applies to imaging the pancreas, focusing on pancreatitis, trauma, pancreatic ductal adenocarcinoma, and other solid and cystic neoplasms. The advantages of DECT over conventional CT are highlighted, including improved lesion detection, radiation dose reduction, and enhanced image contrast. Additionally, data exploring the ideal protocol for pancreatic imaging using DECT is reviewed. Finally, limitations of DECT in pancreatic imaging as well as recommendations for future research are provided.
Online public opinion during the first epidemic wave of COVID-19 in China based on Weibo data
Authors: Shi Wen-zhong , Zeng Fanxin , Zhang Anshu , Tong Chengzhuo , Shen Xiaoqi , Liu Zhewei , Shi Zhicheng
Published: May 2022

As COVID-19 spread around the world, epidemic prevention and control policies have been adopted by many countries. This process has prompted online social platforms to become important channels to enable people to socialize and exchange information. The massive use of social media data mining techniques, to analyze the development online of public opinion during the epidemic, is of great significance in relation to the management of public opinion. This paper presents a study that aims to analyze the developmental course of online public opinion in terms of fine-grained emotions presented during the COVID-19 epidemic in China. It is based on more than 45 million Weibo posts during the period from December 1, 2019 to April 30, 2020. A text emotion extraction method based on a dictionary of emotional ontology has been developed. The results show, for example, that a high emotional effect is observed during holidays, such as New Year. As revealed by Internet users, the outbreak of the COVID-19 epidemic and its rapid spread, over a comparatively short period of time, triggered a sharp rise in the emotion “fear”. This phenomenon was noted especially in Wuhan and the immediate surrounding areas. Over the initial 2 months, although this “fear” gradually declined, it remained significantly higher than the more common level of uncertainty that existed during the epidemic’s initial developmental era. Simultaneously, in the main city clusters, the response to the COVID-19 epidemic in central cities, was stronger than that in neighboring cities, in terms of the above emotion. The topics of Weibo posts, the corresponding emotions, and the analysis conclusions can provide auxiliary reference materials for the monitoring of network public opinion under similar major public events.
Nanosecond-scale impulse generator for biomedical applications of atmospheric-pressure plasma technology
Authors: Gamaleev Vladislav , Shimizu Naohiro , Hori Masaru
Published: May 2022

This study proposes an improved high-voltage fast impulse generator based on an inductive energy storage system with a 4 kV static induction thyristor. Nanosecond-scale impulses with pulse widths below 100 ns and a peak voltage of up to 15 kV can be generated by modifying the high-voltage transformer in the circuit and tuning the circuit capacitor. The resulting device is highly stable and can perform continuously if the discharge parameters are chosen within the recommended range. A plasma jet was operated using the generator at low temperature (below 37 °C). Together with its high stability and potential for continuous operation, the proposed generator offers promise for use in biomedical and agricultural applications. Furthermore, the nanosecond-scale high-voltage impulses produced by the generator enable it to achieve an electron density in the plasma one order of magnitude higher than the commercially available radio frequency plasma jet analog. We also show how to reduce the total cost of the generator.
High precision reconstruction of silicon photonics chaos with stacked CNN-LSTM neural networks
Authors: Cheng Wei , Feng Junbo , Wang Yan , Peng Zheng , Cheng Hao , Ren Xiaodong , Shuai Yubei , Zang Shengyin , Liu Hao , Pu Xun , Yang Junbo , Wu Jiagui
Published: May 2022

Silicon-based optical chaos has many advantages, such as compatibility with complementary metal oxide semiconductor (CMOS) integration processes, ultra-small size, and high bandwidth. Generally, it is challenging to reconstruct chaos accurately because of its initial sensitivity and high complexity. Here, a stacked convolutional neural network (CNN)-long short-term memory (LSTM) neural network model is proposed to reconstruct optical chaos with high accuracy. Our network model combines the advantages of both CNN and LSTM modules. Further, a theoretical model of integrated silicon photonics micro-cavity is introduced to generate chaotic time series for use in chaotic reconstruction experiments. Accordingly, we reconstructed the one-dimensional, two-dimensional, and three-dimensional chaos. The experimental results show that our model outperforms the LSTM, gated recurrent unit (GRU), and CNN models in terms of MSE, MAE, and R-squared metrics. For example, the proposed model has the best value of this metric, with a maximum improvement of 83.29% and 49.66%. Furthermore, 1D, 2D, and 3D chaos were all significantly improved with the reconstruction tasks.