bluuebunny/crossref_metadata_2025 huggingface dataset:
Adaptive Human Behavior in a Two‐Worm Interaction Model
Authors: Song Li-Peng , Han Xie , Liu Dong-Ming , Jin Zhen
Published: November 2012

The complex interactions among internet worms have great impact on the dynamics of worms. To contain the propagation of worms, it is necessary to characterize these interactions. Therefore, a two‐worm interaction model is presented in this paper. Different from previous researches, we have considered the influence of adaptive human reaction stirred by one cooperative worm on the other worm in the model. The model’s equilibria and their stability conditions are obtained mathematically and verified by simulations. Results indicate that considering adaptive human behavior significantly changes the prospective propagation course of worms and that this consideration has implications for designing counterworm methods.
An Epidemiological Study on Pattern and Incidence of Mandibular Fractures
Authors: Natu Subodh S. , Pradhan Harsha , Gupta Hemant , Alam Sarwar , Gupta Sumit , Pradhan R. , Mohammad Shadab , Kohli Munish , Sinha Vijai P. , Shankar Ravi , Agarwal Anshita
Published: November 2012

Mandible is the second most common facial fracture. There has been a significant increase in the number of cases in recent years with the advent of fast moving automobiles. Mandibular fractures constitute a substantial proportion of maxillofacial trauma cases in Lucknow. This study was undertaken to study mandibular fractures clinicoradiologically with an aim to calculate incidence and study pattern and the commonest site of fractures in population in and around Lucknow. Patient presenting with history of trauma at various centers of maxillofacial surgery in and around Lucknow were included in this study. Detailed case history was recorded followed by thorough clinical examination, and radiological interpretation was done for establishing the diagnosis and the data obtained was analyzed statistically. Out of 66 patients with mandibular fractures, highest percentage was found in 21–30 years of age with male predominance. Road traffic accidents were the most common cause of fracture with parasymphysis being commonest site. Commonest combination was parasymphysis with subcondyle. There was no gender bias in etiology with number of fracture sites. The incidence and causes of mandibular fracture reflect trauma patterns within the community and can provide a guide to the design of programs geared toward prevention and treatment.
Effects of Diet, Aerobic Exercise, or Both on Non-HDL-C in Adults: A Meta-Analysis of Randomized Controlled Trials
Authors: Kelley George A. , Kelley Kristi S.
Published: November 2012

Purpose. To use the meta-analytic approach to examine the effects of diet (D), aerobic exercise (E), or both (DE) on non-high-density lipoprotein cholesterol (non-HDL-C) in adults. Methods. Randomized controlled trials in adults ≥18 years of age were included. A mixed-effect model was used to combine effect size (ES) results within each subgroup and to compare subgroups (Qb). Heterogeneity was examined using the Q and I2 statistics, and 95% confidence intervals (CI) were also calculated. Statistical significance was set at P≤0.05, while a trend for statistical significance was set between P>0.05, and ≤0.10. Results. A statistically significant exercise minus control group decrease in non-HDL-C was found for DE (7 ESs, 389 participants, x¯=-11.1 mg/dL, 95%  CI=−21.7
to −0.6, P=0.04, Q=2.4, P=0.88, I2=0%), a trend for the D group (7 ESs, 402 participants, x¯=−8.5 mg/dL, 95%  CI=−18.6 to 1.6, P=0.10, Q=0.76, P=0.99, I2=0%), and no change for the E group (7 ESs, 387 participants, x¯=3.0 mg/dL, 95%   CI=−7.1 to 13.1, P=0.56, Q=0.78, P=0.99, I2=0%). Overall, no statistically significant between-group differences were found (Qb=4.1, P=0.12). Conclusions. Diet combined with aerobic exercise may reduce non-HDL-C among adults in some settings.
Aqueous Extract ofSolanum nigrumLeaf Activates Autophagic Cell Death and Enhances Docetaxel-Induced Cytotoxicity in Human Endometrial Carcinoma Cells
Authors: Tai Cheng-Jeng , Wang Chien-Kai , Chang Yu-Jia , Lin Chi-Shian , Tai Chen-Jei
Published: November 2012

Chemotherapy is the main approach in dealing with advanced and recurrent endometrial cancer. An effective complementary ingredient can be helpful in improving the clinical outcome. Aqueous extract ofSolanum nigrumleaf (AE-SN) is a principal ingredient for treating cancer patients in traditional Chinese medicinal practice but lacks sufficient evidence to verify its tumor suppression efficacy. This study evaluated the antitumor effects of AE-SN and also assessed the synergistic effects of AE-SN with docetaxel On the human endometrial cancer cell lines, HEC1A, HEC1B, and KLE. The activation of apoptotic markers, caspase-3 and poly-ADP-ribose polymerase, and autophagic marker, microtubule-associated protein 1 light chain 3 A/B, wAS determined to clarify the cell death pathways responsible for AE-SN induced tumor cell death. Results indicated that AE-SN-treatment has significant cytotoxicity on the tested endometrial cancer cells with accumulation of LC3 A/B II and demonstrated a synergistic effect of AE-SN and docetaxel in HEC1A and HEC1B cells, but not KLE cells. In conclusion, AE-SN treatment was effective in suppressing endometrial cancer cells via the autophagic pathway and was also capable of enhancing the cytotoxicity of docetaxel in human endometrial cancer cells. Our results provide meaningful evidence for integrative cancer therapy in the future.
The Diagnosis of Vertebrobasilar Insufficiency Using Transcranial Doppler Ultrasound
Authors: Alnaami Ibrahim , Siddiqui Muzaffer , Saqqur Maher
Published: November 2012

Background. Vertebrobasilar insufficiency (VBI) is a hemodynamic posterior circulation transient ischemic attack (TIA) caused by intermittent vertebral artery occlusion that is induced by a head rotation or extension. VBI may result from large vessel atherosclerotic disease, dissection, cervical compressive lesions, and subclavian steal phenomenon. Diagnostic transcranial Doppler (TCD) of VBI disease and hemodynamic posterior circulation TCD monitoring in symptomatic positions might prove a useful tool in establishing the diagnosis.Patient and Material/Method. A 50-year-old Caucasian man presented with a one-year history of episodic positional vertigo and ataxic gait that were induced by a neck extension and resolved by an upright position or a neck flexion. Computed tomography angiogram (CTA) and TCD confirmed the presence of VBI where no blood flow was detected through posterior cerebral arteries in the symptomatic position (head extension position).Conclusion. TCD is a promising noninvasive technique that might have a role as a diagnostic test in VBI.
Conductivity at Low Humidity of Materials Derived from Ferroxane Particles
Authors: Lapina Alberto , Holtappels Peter , Mogensen Mogens
Published: November 2012

Carboxylic-acid-stabilisedγ-FeOOH particles (ferroxanes) are synthesized using a precipitation from aqueous solution, and a following reaction with acetic acid. The materials produced with these powders are investigated by XRD, SEM, nitrogen adsorption-desorption, and impedance spectroscopy. Conductivity of both sintered and unsintered materials decreases strongly with a decrease in water partial pressure in the atmosphere during the test. The highest conductivity (7·10−3 S cm−1) is measured in air (pH2O = 0.037 atm) at room temperature on sintered material. The conductivity values are compared with other works in the literature and the dependence of conductivity on surface area and pore size is discussed. It is suggested that both unsintered and sintered materials act as proton conductors at room temperature under moderate humidity conditions.
Lighting Up RNA-Cleaving DNAzymes for Biosensing
Authors: Tram Kha , Kanda Pushpinder , Li Yingfu
Published: November 2012

The development of thein vitroselection technique has allowed the isolation of functional nucleic acids, including catalytic DNA molecules (DNAzymes), from random-sequence pools. The first-ever catalytic DNA obtained by this technique in 1994 is a DNAzyme that cleaves RNA. Since then, many other RNase-like DNAzymes have been reported from multiplein vitroselection studies. The discovery of various RNase DNAzymes has in turn stimulated the exploration of these enzymatic species for innovative applications in many different areas of research, including therapeutics, biosensing, and DNA nanotechnology. One particular research topic that has received considerable attention for the past decade is the development of RNase DNAzymes into fluorescent reporters for biosensing applications. This paper provides a concise survey of the most significant achievements within this research topic.
Complete Synchronization of Strictly Different Chaotic Systems
Authors: Solís-Perales Gualberto
Published: November 2012

The criteria for complete synchronization of strictly different chaotic systems using feedback
control are presented in this paper. Complete synchronization is achieved when all the
states in the slave system are synchronous with the corresponding state in the master system.
We illustrate that using a single input and single output control scheme, the synchronization of
a class of strictly different systems is obtained in partial form. To overcome this problem we
show that a multiple input and multiple output control scheme with an equal number of inputs
and outputs than the order system is required in order to obtain the complete synchronization.
This procedure is used to synchronize the Rössler and the Chen systems as an example. We also
demonstrate that if the synchronization scheme considers less inputs and outputs, the partial‐state synchronization is obtained.
Influence of the Crystal Texture on Raman Spectroscopy of the AlN Films Prepared by Pulse Laser Deposition
Authors: Wang Jingjing , Chen Da , Xu Yan , Liu Qixin , Zhang Luyin
Published: November 2012

We investigate the Raman scattering of the AlN films prepared by pulse laser deposition. The Raman spectrum and the X-ray diffraction (XRD) patterns of the AlN films were compared to find out the influence of the crystal texture on the Raman scattering. TheE2(high) andA1(TO) scattering modes were observed in Raman spectra. The results show that the orientation and the crystal quality of the AlN films have a great impact on these Raman scattering modes. The deterioration of (002) orientation and the appearance of other orientations in the XRD patterns lead to the weakening of theE2(high) mode and strengthening of theA1(TO) mode in the Raman spectrum. In addition, theE2(high) peak is broadened with the increasing of the width of the X-ray rocking curve. The broadening of the Raman peaks can be associated with degeneration in crystal quality. Furthermore, by combining the energy shift ofE2(high) mode with the measured residual stress in the films, the Raman-stress factor of the AlN films prepared by pulse laser deposition is −4.45 cm−1/GPa for theE2(high) mode.
Acoustical Behaviour of Sodium Nitroprusside in Aquo‐Organic Solvent Media at 308.15 K
Authors: Das Monalisa , Das Smrutiprava , Pattanaik A. K.
Published: November 2012

Density and ultrasonic velocity have been measured for sodium nitroprusside in aqueous solutions of CH3OH, ethylene glycol, DMSO, and n‐propanol solvents at 308.15 K. A quantitative relationship has been established among the acoustical properties like ultrasonic velocity (U), adiabatic compressibility (β), intermolecular free length (Lf), acoustic impedance (Z), apparent molar compressibility (Kϕ), apparent molar volume (Vϕ), limiting apparent molar compressibility () limiting apparent molar volume (), and their constants (SK, Sv). From the obtained values, molecular interaction study has been made successfully in the light of these acoustical properties through hydrogen bonding in solute and solvent mixture.
MYC Acts via the PTEN Tumor Suppressor to Elicit Autoregulation and Genome-Wide Gene Repression by Activation of the Ezh2 Methyltransferase
Authors: Kaur Mandeep , Cole Michael D.
Published: November 2012

The control of normal cell growth is a balance between stimulatory and inhibitory signals. MYC is a pleiotropic transcription factor that both activates and represses a broad range of target genes and is indispensable for cell growth. Whereas much is known about gene activation by MYC, there is no established mechanism for the majority of MYC-repressed genes. We report that MYC transcriptionally activates the PTEN tumor suppressor in normal cells to inactivate the phosphoinositide 3-kinase (PI3K) pathway, thus suppressing AKT activation. Suppression of AKT enhances the activity of the EZH2 histone methyltransferase, a subunit of the epigenetic repressor Polycomb Repressive Complex 2 (PRC2), while simultaneously stabilizing the protein. MYC-mediated enhancement in EZH2 protein level and activity results in local and genome-wide elevation in the repressive H3K27me3 histone modification, leading to widespread gene repression including feedback autoregulation of the MYC gene itself. Depletion of either PTEN or EZH2 and inhibition of the PI3K/AKT pathway leads to gene derepression. Importantly, expression of a phospho-defective EZH2 mutant is sufficient to recapitulate nearly half of all MYC-mediated gene repression. We present a novel epigenetic model for MYC-mediated gene repression and propose that PTEN and MYC exist in homeostatic balance to control normal growth, which is disrupted in cancer cells. Cancer Res; 73(2); 695–705. ©2012 AACR.
Epigenetic Regulation by Z-DNA Silencer Function Controls Cancer-Associated ADAM-12 Expression in Breast Cancer: Cross-talk between MeCP2 and NF1 Transcription Factor Family
Authors: Ray Bimal K. , Dhar Srijita , Henry Carolyn , Rich Alexander , Ray Alpana
Published: November 2012

A disintegrin and metalloprotease domain-containing protein 12 (ADAM-12) is upregulated in many human cancers and promotes cancer metastasis. Increased urinary level of ADAM-12 in breast and bladder cancers correlates with disease progression. However, the mechanism of its induction in cancer remains less understood. Previously, we reported a Z-DNA–forming negative regulatory element (NRE) in ADAM-12 that functions as a transcriptional suppressor to maintain a low-level expression of ADAM-12 in most normal cells. We now report here that overexpression of ADAM-12 in triple-negative MDA-MB-231 breast cancer cells and breast cancer tumors is likely due to a marked loss of this Z-DNA–mediated transcriptional suppression function. We show that Z-DNA suppressor operates by interaction with methyl-CpG-binding protein, MeCP2, a prominent epigenetic regulator, and two members of the nuclear factor 1 family of transcription factors, NF1C and NF1X. While this tripartite interaction is highly prevalent in normal breast epithelial cells, both in vitro and in vivo, it is significantly lower in breast cancer cells. Western blot analysis has revealed significant differences in the levels of these 3 proteins between normal mammary epithelial and breast cancer cells. Furthermore, we show, by NRE mutation analysis, that interaction of these proteins with the NRE is necessary for effective suppressor function. Our findings unveil a new epigenetic regulatory process in which Z-DNA/MeCP2/NF1 interaction leads to transcriptional suppression, loss of which results in ADAM-12 overexpression in breast cancer cells. Cancer Res; 73(2); 736–44. ©2012 AACR.
Glutathione-Deficient Mice Have Increased Sensitivity to Transplacental Benzo[a]pyrene-Induced Premature Ovarian Failure and Ovarian Tumorigenesis
Authors: Lim Jinhwan , Lawson Gregory W. , Nakamura Brooke N. , Ortiz Laura , Hur Jin A. , Kavanagh Terrance J. , Luderer Ulrike
Published: November 2012

Polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene (BaP) are ubiquitous environmental pollutants found in tobacco smoke, air pollution, and grilled foods. Prenatal exposure to BaP causes premature reproductive senescence in mice, and other PAHs are transplacental ovarian carcinogens. Glutathione (GSH) is critical for detoxification of the reactive metabolites of PAHs. Therefore, we hypothesized that mice that are genetically deficient in GSH synthesis, due to deletion of the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in GSH synthesis, have increased destruction of oogonia, premature ovarian failure, and ovarian tumorigenesis after transplacental BaP exposure compared with Gclm+/+ females. Gclm+/− female and male mice were mated, and dams were treated with 0, 2, or 10 mg/kg/d BaP in sesame oil by gavage from gestational days 7 to 16. Compared with oil-treated F1 females of the same genotype, Gclm−/− prenatally BaP-treated females had significantly greater decrements in offspring production than Gclm+/+ BaP-treated females. Similarly, we observed significant BaP dose × Gclm genotype interactions on ovarian follicle counts and ovarian tumor multiplicity at 7.5 months of age, with Gclm−/− females having greater decrements in follicle numbers and more ovarian tumors in response to prenatal BaP exposure than Gclm+/+ females. The ovarian tumors were positive for the epithelial marker cytokeratin. Our results show that prenatal exposure of females to BaP causes premature ovarian failure and ovarian tumorigenesis and that embryonic GSH deficiency due to deletion of Gclm increases sensitivity to these transplacental ovarian effects of BaP. Cancer Res; 73(2); 908–17. ©2012 AACR.
Impact of Ischemia and Procurement Conditions on Gene Expression in Renal Cell Carcinoma
Authors: Liu Nick W. , Sanford Thomas , Srinivasan Ramaprasad , Liu Jack L. , Khurana Kiranpreet , Aprelikova Olga , Valero Vladimir , Bechert Charles , Worrell Robert , Pinto Peter A. , Yang Youfeng , Merino Maria , Linehan W. Marston , Bratslavsky Gennady
Published: November 2012

Purpose: Previous studies have shown that ischemia alters gene expression in normal and malignant tissues. There are no studies that evaluated effects of ischemia in renal tumors. This study examines the impact of ischemia and tissue procurement conditions on RNA integrity and gene expression in renal cell carcinoma.

Experimental Design: Ten renal tumors were resected without renal hilar clamping from 10 patients with renal clear cell carcinoma. Immediately after tumor resection, a piece of tumor was snap frozen. Remaining tumor samples were stored at 4°C, 22°C, and 37°C and frozen at 5, 30, 60, 120, and 240 minutes. Histopathologic evaluation was conducted on all tissue samples, and only those with greater than 80% tumor were selected for further analysis. RNA integrity was confirmed by electropherograms and quantitated using RNA integrity number index. Altered gene expression was assessed by paired, two-sample t test between the zero time point and aliquots from various conditions obtained from the same tumor.

Results: One hundred and forty microarrays were conducted. Some RNA degradation was observed 240 minutes after resection at 37°C. The expression of more than 4,000 genes was significantly altered by ischemia times or storage conditions. The greatest gene expression changes were observed with longer ischemia time and warmer tissue procurement conditions.

Conclusion: RNA from kidney cancer remains intact for up to 4 hours post surgical resection regardless of storage conditions. Despite excellent RNA preservation, time after resection and procurement conditions significantly influence gene expression profiles. Meticulous attention to preacquisition variables is of paramount importance for accurate tumor profiling. Clin Cancer Res; 19(1); 42–49. ©2012 AACR.
Anemia in Heart Failure: Association of Hepcidin Levels to Iron Deficiency in Stable Outpatients
Authors: Weber Cristiane S. , Beck-da-Silva Luis , Goldraich Livia A. , Biolo Andréia , Clausell Nadine
Published: November 2012

Background: Anemia is a prevalent condition in heart failure with multiple potential causes. The complex interaction between iron stores, hepcidin, inflammation and anemia is poorly comprehended. We tested the hypothesis that, in stable heart failure patients with anemia, hepcidin is associated with iron deficiency status irrespective of inflammation. Methods and Results: Stable systolic heart failure outpatients with and without anemia underwent a complete iron panel, erythropoietin, hepcidin and tumor necrosis factor (TNF)-α assessment. Sixty outpatients were studied. Anemic patients (n = 38, mean hemoglobin 11.4 ± 1 g/dl) were older (69.6 ± 9.6 vs. 58 ± 10.8 years old, p < 0.01) compared with nonanemic patients (n = 22, mean hemoglobin 13.8 ± 1.1 g/dl). Iron deficiency was present in 42% of patients with anemia. TNF-α and hepcidin were 29 and 21% higher in patients with anemia, respectively, compared to nonanemic patients; however, no correlations were found between hepcidin and TNF-α levels. Hepcidin levels in the lower tertile (<31.7 ng/ml) were strongly associated with iron deficiency (OR 16.5, 95% CI 2.2–121.2; p < 0.01). Conclusion: In stable heart failure patients with anemia, hepcidin levels may be more importantly regulated by patients’ iron stores than by inflammation.
Do Depression and Educational Attainment Mediate the Association between Ethnicity and Dementia?
Authors: Momtaz Yadollah Abolfathi , Hamid Tengku Aizan , Yusoff Suraya , Ibrahim Rahimah
Published: November 2012

Introduction: Research shows marked differences in the prevalence of dementia among different ethnic groups. However, there is a relative dearth of studies focusing on how ethnicity may influence dementia. The main aim of the current study is to test potential mediating effects of depression and level of education on the association between ethnicity and dementia. Methods: The sample for this study, consisting of 2,796 community-dwelling elderly people aged 60 years and older, was drawn from a cross-sectional national survey entitled ‘Mental Health and Quality of Life of Older Malaysians'. The Malaysian adapted version of the Geriatric Mental State-Automated Geriatric Examination for Computer-Assisted Taxonomy was used to assess dementia and depression. Data analysis was conducted using IBM SPSS version 19. Results: As expected, the result of the χ2 analysis revealed significant ethnic difference in the prevalence of dementia (χ2 = 58.05, p ≤ 0.001). The results of the mediational analyses revealed that depression (Z = 4.05, p ≤ 0.001) and education (Z = 2.78, p ≤ 0.01) significantly, but partially, mediate the association between ethnicity and dementia. This suggests that disparities of depressive symptoms and education contribute to ethnic difference in the prevalence of dementia. Conclusions: These findings provide more insight into how ethnicity may influence an individual's vulnerability to dementia. The limitations of the study along with implications of the findings and needs for further study are discussed.
Translocation t(11;17) in de novo Myelodysplastic Syndrome Not Associated with Acute Myeloid or Acute Promyelocytic Leukemia
Authors: Baljevic Muhamed , Abdel-Wahab Omar , Rampal Raajit , Maslak Peter G. , Klimek Virginia M. , Rosenblat Todd L. , Douer Dan , Levine Ross L. , Tallman Martin S.
Published: November 2012

Translocation t(11;17) is a well-recognized variant of acute promyelocytic leukemia (APL) and has also been identified in patients with mixed-lineage leukemia (MLL) non-APL acute myeloid leukemia. Here, we describe two patients bearing translocation t(11;17) presenting with a clinical diagnosis of de novo myelodysplastic syndrome (MDS): the first with sole karyotypic abnormality 46,XY,t(11;17)(p11.2; p13) and the second where it represented one of the two karyotypic abnormalities 46,XX,del(5)(q13q33)46,XX,del(5)(q13q33),t(11;17)(q24;q23). Molecular characterization of both cases failed to identify fusion transcripts involving MLL or PLZF-RARA and no collaborating somatic mutations commonly found among MDS patients were seen in either case, suggesting the presence of an as yet unidentified oncogenic fusion protein.
CNI-1493 Attenuates Neuroinflammation and Dopaminergic Neurodegeneration in the Acute MPTP Mouse Model of Parkinson's Disease
Authors: Noelker Carmen , Stuckenholz Vanessa , Reese Jens-Peter , Alvarez-Fischer Daniel , Sankowski Roman , Rausch Tanja , Oertel Wolfgang H. , Hartmann Andreas , van Patten Sonya , Al-Abed Yousef , Bacher Michael
Published: November 2012

Background: Parkinson's disease (PD) is associated with neurodegeneration of dopaminergic neurons in the substantia nigra. Neuroinflammatory processes have been shown to be a key component of this neurodegeneration and, as such, small molecule compounds which inhibit these inflammatory events are a critical research focus. Objective: CNI-1493 is an anti-inflammatory compound that strongly inhibits macrophages and also stimulates the cholinergic anti-inflammatory pathway. We have examined whether CNI-1493 has a neuroprotective effect in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. Methods: CNI-1493 (8 mg/kg i.p.) or placebo administration was started 1 day before MPTP intoxication and repeated daily until sacrifice after MPTP intoxication. C57/Bl6 mice - either treated with CNI-1493 or with placebo - were injected intraperitoneally 4 times at 2-hour intervals with either 20 mg/kg MPTP-HCl or a corresponding volume of saline. Two or 7 days after the end of the MPTP intoxication, the animals were killed and their brains were processed for further analysis. Results: Administration of CNI-1493 markedly protected tyrosine hydroxylase-positive substantia nigra neurons against MPTP neurotoxicity. CNI-1493 treatment in the MPTP model was also accompanied by a profound reduction of activated microglia within the substantia nigra, as measured by ionized calcium-binding adapter molecule-1 staining. Conclusions: These findings support that CNI-1493 could reduce the MPTP-induced toxicity likely by inhibition of neuroinflammatory responses. The neuroprotective effect of CNI-1493 suggests that CNI-1493 might be a valuable neuroprotective candidate in the future treatment of PD.
The Relatively Good Outcome of Cerebellum-Brainstem Ischemic Strokes
Authors: Korn-Lubetzki Isabelle , Molshatzki Noa , Benderly Michal , Steiner Israel ,   on behalf of the NASIS Investigators
Published: November 2012

Background: Our clinical experience suggests that the outcome of cerebellum-brainstem ischemic strokes is better than that of hemispheric ischemic strokes. Methods: Within the setting of 2 national Israeli prospective stroke surveys, we analyzed risk factors, etiology, severity at presentation, and prognosis of first ischemic cerebellum-brainstem stroke (259 patients), comparing with strokes within the anterior circulation (1,029 patients). Results: Patients with cerebellum-brainstem strokes were younger and had less frequently atrial fibrillation and congestive heart failure. Cardioembolic etiology was significantly less prevalent (p < 0.001). Severity at presentation was milder (p < 0.001). At discharge, worsening of the modified Rankin Scale was present in a smaller number of patients (p < 0.001); more returned to their home (p < 0.001). Six-month and 1-year mortality were lower (p < 0.001 for both). Adjusted logistic regression models showed that patients with cerebellum-brainstem strokes had 50% smaller chances of dying (OR 0.55; 95% CI 0.31–0.98) and a smaller chance of worsening of the modified Rankin Scale at discharge (OR 0.61; 95% CI 0.46–0.82). Conclusions: Cerebellum-brainstem strokes are less frequently cardioembolic, have a less severe presentation, and carry a better immediate and long-term prognosis.
Evaluation of the RENAL Nephrometry Scoring System in Adopting Nephron-Sparing Surgery for cT1 Renal Cancer
Authors: Yasuda Yosuke , Yuasa Takeshi , Yamamoto Shinya , Urakami Shinji , Ito Masaya , Sukegawa Gen , Kitsukawa Shinichi , Yonese Junji , Fukui Iwao
Published: November 2012

Objective: The RENAL nephrometry scoring system characterizes tumors according to their size, growth pattern, location and nearness to the renal sinus or collecting system. The current study aims to evaluate the RENAL nephrometry scoring system in adopting nephron-sparing surgery (NSS) for cT1 renal cancer. Methods: Clinicopathological data of 200 consecutive patients who had undergone radical nephrectomy (RN) or NSS for clinical stage T1 renal cell cancer at our single institution during 2005-2009 were investigated retrospectively. Results: Of 200 patients, 103 were scheduled for RN, whereas 97 were planned to undergo NSS, 9 of whom actually underwent RN. Those who were planned to undergo NSS were younger and had smaller tumors (p < 0.001). The median RENAL score was significantly lower among those who were originally assigned to NSS (5, range 4-10) versus RN (8, range 4-11) (p < 0.001). Three months after surgery, the renal function of patients who had been scheduled for NSS was significantly better than in those treated by RN (p < 0.001). Conclusions: This study suggests that the RENAL nephrometry scoring system is a useful tool in adopting NSS for cT1 renal cancer and that objective decision-making for NSS was possible.
Steps through the Revision Process of Reproductive Health Sections of ICD-11
Authors: Chou Doris , Tunçalp Özge , Hotamisligil Selen , Norman Jane , Say Lale ,   On behalf of Genito-Urinary Reproductive Medicine TAG
Published: November 2012

In 2007, the WHO initiated an organizational structure for the 11th revision of the International Classification of Diseases (ICD). Effective deployment of ICD-derived tools facilitates the use and collection of health information in a variety of resource settings, promoting quantitatively informed decisions. They also facilitate comparison of disease incidence and outcomes between different countries and different health care systems around the world. The Department of Reproductive Health and Research (RHR) coordinates the revision of chapters 14 (diseases of the genitourinary system), 15 (pregnancy, childbirth, and puerperium), and 16 (conditions originating in the perinatal period). RHR convened a technical advisory group (TAG), the Genito-Urinary Reproductive Medicine (GURM) TAG, for the ICD revision. The TAG’s work reflects the collective understanding of sexual and reproductive health and is now available for review within the ICD-11 revision process.
The Special Programme of Research in Human Reproduction: Forty Years of Activities to Achieve Reproductive Health for All
Authors: Benagiano Giuseppe , d’Arcangues Catherine , Harris Requejo Jennifer , Schafer Alessandra , Say Lale , Merialdi Mario
Published: November 2012

The Special Programme of Research in Human Reproduction (HRP), co-sponsored by the UNDP, UNFPA, WHO, and the World Bank, is celebrating 40 years of activities with an expansion of its mandate and new co-sponsors. When it began, in 1972, the main focus was on evaluating the acceptability, effectiveness, and safety of existing fertility-regulating methods, as well as developing new, improved modalities for family planning. In 1994, HRP not only made major contributions to the Plan of Action of the International Conference on Population and Development (ICPD); it also broadened its scope of work to include other aspects of health dealing with sexuality and reproduction, adding a specific perspective on gender issues and human rights. In 2002, HRP’s mandate was once again broadened to include sexually transmitted infections and HIV/AIDS and in 2003 it was further expanded to research activities on preventing violence against women and its many dire health consequences. Today, the work of the Programme includes research on: the sexual and reproductive health of adolescents, women, and men; maternal and perinatal health; reproductive tract and sexually transmitted infections (including HIV/AIDS); family planning; infertility; unsafe abortion; sexual health; screening for cancer of the cervix in developing countries, and gender and reproductive rights. Additional activities by the Programme have included: fostering international cooperation in the field of human reproduction; the elaboration of WHO’s first Global Reproductive Health Strategy; work leading to the inclusion of ICPD’s goal ‘reproductive health for all by 2015’ into the Millennium Development Goal framework; the promotion of critical interagency statements on the public health, legal, and human rights implications of female genital mutilation and gender-biased sex selection. Finally, HRP has been involved in the creation of guidelines and tools, such as the ‘Medical eligibility criteria for contraceptive use’, the ‘Global handbook for family planning providers’, the ‘Definition of core competencies in primary health care’, and designing tools for operationalizing a human rights approach to sexual and reproductive health programmes.
Lymphangioma of Pyeloureteral Junction: An Extremely Rare Case
Authors: Topaloglu H. , Karakoyunlu N. , Ozok U. , Dilli A. , Onder E. , Sagnak L. , Ersoy H.
Published: November 2012

Benign tumors of the proximal ureter are very rare. Many of them could be confused with urothelial carcinoma and unnecessarily treated by nephrectomy. In this case, we present the treatment of a lymphangioma localized in the upper ureter, which is an example of benign tumor. During treatment percutaneous tumor resection, an organ-sparing approach, was employed.
Gene Polymorphisms of Interleukin-17 and Interleukin-17 Receptor Are Associated with End-Stage Kidney Disease
Authors: Kim Yang-Gyun , Kim Eun-Young , Ihm Chun-Gyoo , Lee Tae-Won , Lee Sang-Ho , Jeong Kyung-hwan , Moon Ju-Young , Chung Joo-Ho , Kim Yeong-Hoon
Published: November 2012

Background: Inflammation could be a causal factor in progression of chronic kidney disease. To date, there is convincing experimental and clinical evidence to support the notion that interleukin (IL)-17-producing T cells contribute to kidney injury in renal diseases. However, the genetic relationship between end-stage renal disease (ESRD) and the T-helper 17 pathway has never been studied. In this study, we hypothesized that polymorphisms of IL-17 or their receptors may be associated with ESRD. Methods: A total of 290 nondiabetic ESRD patients and 289 normal controls were included. We analyzed 13 single nucleotide polymorphisms located within the four genes of IL17A, IL17E, IL17RA and IL17RB. Results: The ESRD patients had a significantly higher allele frequency compared to control subjects for the IL17E rs10137082*C and IL17RA rs4819554*A alleles. Genotyping analysis demonstrated that 2 SNPs among 13 were significantly associated with ESRD after adjusting for age and sex, which were shown by IL17E rs10137082 (odds ratio (OR) 1.48 in codominant 1, OR 1.54 in dominant, OR 1.47 in log-additive) and IL17RA rs4819554 (OR 1.46 in codominant 1, OR 1.79 in codominant 2, OR 1.54 in dominant, OR 1.39 in log-additive). Conclusions: Two polymorphisms within the IL17E and IL17RA genes are associated with ESRD independent of age and sex. This is the first finding to suggest that genetic variations of IL17 genes affect the risk of development of ESRD.
Bipolar versus Monopolar Transurethral Resection of the Prostate: Results of a Comparative, Prospective Bicenter Study – Perioperative Outcome and Long-Term Efficacy
Authors: Neyer Michael , Reissigl Andreas , Schwab Christoph , Pointner Joseph , Abt Dominik , Bachmayer Christian , Schmid Hans-Peter , Engeler Daniel S.
Published: November 2012

Objectives: To compare bipolar and monopolar transurethral resection of the prostate (TURP) in a comparative prospective study at two urology centers. Methods: Of 212 patients with symptomatic benign prostatic hyperplasia entered prospectively into the study, 111 underwent bipolar and 101 monopolar TURP. Patients were treated in two consecutive series with each surgical method at both centers. Improvement in peak flow rate, postvoid residual, International Prostate Symptom Score, and quality of life score postoperatively and at 3, 12, 24 and 36 months, as well as long-term adverse events were compared. Regarding safety, duration of surgery, postoperative catheterization and hospitalization time, amount of fluid absorption, frequency of transurethral resection (TUR) syndrome, and risk of hemorrhage were evaluated. Results: Patient characteristics of the two series were comparable. The risk of developing TUR syndrome (p = 0.32) and bleeding tendency (p = 0.52) did not differ significantly between groups. Significant differences were seen for duration of surgery and resection speed. All functional parameters improved significantly during follow- up, with no relevant differences between surgical groups. Conclusions: Since no major differences in efficacy and safety were seen between the surgical groups, we feel that the monopolar technique still has a valuable place in TURP.
High-Dose Calcitriol, Docetaxel and Zoledronic Acid in Patients with Castration-Resistant Prostate Cancer: A Phase II Study
Authors: Shamseddine Ali , Farhat Fadi S. , Elias Elias , Khauli Raja B. , Saleh Ahmad , Bulbul Mohammad A.
Published: November 2012

Introduction: Docetaxel has become the standard chemotherapy for patients with castration-resistant prostate cancer (CRPC). We wanted to assess the efficacy and safety of a weekly high-dose calcitriol, docetaxel and zoledronic acid combination in CRPC. Patients and Methods: Thirty patients were enrolled to receive calcitriol 0.5 µg/kg orally in 4 divided doses over 4 h on day 1 of each treatment week, docetaxel 36 mg/m2 i.v. infusion on day 2 of each treatment week and zoledronic acid 4 mg i.v. on day 2 of the first and fifth week of each cycle. Treatment was administered weekly for 6 consecutive weeks on an 8-week cycle. Results: Out of 23 evaluable patients, there was a response of prostate-specific antigen (PSA) in 11 patients (47.8%); 6 (26.1%) had a stable PSA level for a median of 4.2 months. The median survival time was 15 months (95% confidence interval 13.9–16.1 months). The regimen was generally tolerated; anemia was the only grade 3/4 hematological toxicity in 2 patients. Conclusions: This regimen was tolerated, and half of the patients had a PSA response. Although our response rates are inferior to some studies using docetaxel, we believe our response rates are acceptable knowing that we are treating CRPC, which still has variable outcomes.
Removal of Large or Giant Sporadic Vestibular Schwannomas via Translabyrinthine Approach: A Report of 115 Cases
Authors: Zhang Zhihua , Wang Zhaoyan , Huang Qi , Yang Jun , Wu Hao
Published: November 2012

Background/Aims: The present study was a retrospective analysis of surgical outcomes of large or giant vestibular schwannomas (VSs) via a translabyrinthine approach (TLA). Methods: One hundred and fifteen sporadic large or giant VSs (maximal diameter in the cerebellopontine angle ≥31 mm) were operated via TLA between January 2001 and December 2010. We divided patients into two groups: cystic VS (CVS) and solid VS (SVS) group. The surgical outcomes were recorded and compared. Results: Total, near total, and subtotal tumor removal rate was 89.6, 7.8, and 2.6%, respectively. The near total removal rate in CVS was higher than that in SVS (16.7 vs. 3.8%). The anatomical facial nerve (FN) integrity was preserved in 101 patients (87.8%). More FNs in CVS were interrupted (22.2%). There were 29.6, 56.5, and 13.9% of patients who had a short-term (1 month) FN function of House-Brackmann grade I or II, III or IV, and V or VI, respectively. The CVS had worse FN function than the SVS group. The mortality rate was 0.9%. Cerebrospinal fluid leakage occurred in 8 patients (7.0%). Four (3.5%) patients had recurrence. Conclusions: Cyst formation is a crucial factor for surgical outcome of VS. With near total or subtotal tumor removal, worse functional outcomes in large or giant CVSs should be foreseen.
The Benefits of Keeping Idle Hands Busy
Authors: Duwe Grant
Published: November 2012

This study evaluated the effectiveness of EMPLOY, a prisoner reentry employment program, by examining recidivism and postrelease employment outcomes among 464 offenders released from Minnesota prisons between 2006 and 2008. As outcome data were collected on the 464 offenders through the end of June 2010, the average follow-up period was 28 months. Observable selection bias was minimized by using propensity score matching to create a comparison group of 232 nonparticipants who were not significantly different from the 232 EMPLOY offenders. Results from the Cox regression analyses revealed that participating in EMPLOY reduced the hazard ratio for recidivism by 32% to 63%. The findings further showed that EMPLOY increased the odds of gaining postrelease employment by 72%. Although EMPLOY did not have a significant impact on hourly wage, the overall postrelease wages for program participants were significantly higher because they worked a greater number of hours. The study concludes by discussing the implications of these findings.
Humane Orientation as a New Cultural Dimension of the GLOBE Project
Authors: Schlösser Oliver , Frese Michael , Heintze Anna-Maria , Al-Najjar Musaed , Arciszewski Thomas , Besevegis Elias , Bishop George D. , Bonnes Mirilia , Clegg Chris W. , Drozda-Senkowska Ewa , Gaborit Mauricio , Garzon Dayra , Hansen Tia G. B. , Heszen Irena , Juhasz Marta , Keating Mary A. , Mangundjaya Wustari , Mansor Norma , Mitchelson Jacqueline K. , Ortiz-Reynoso Alejandra , Pandey Janak , Pavakanun Ubolwanna , Pavlopoulos Vassilis , Peiro Jose M. , Potocnik Kristina , Restrepo-Espinosa Maria H. , Semmer Norbert , Tupinamba Antonio C. , Ventura Elizabeth R. , Whoolery Matthew , Zhang Kan
Published: November 2012

We validate, extend, and empirically and theoretically criticize the cultural dimension of humane orientation of the project GLOBE (Global Leadership and Organizational Behavior Effectiveness Research Program). Theoretically, humane orientation is not just a one-dimensionally positive concept about being caring, altruistic, and kind to others as discussed by Kabasakal and Bodur (2004), but there is also a certain ambivalence to this concept. We suggest differentiating humane orientation toward in-group members from humane orientation toward out-group members. A multicountry construct validation study used student samples from 25 countries that were either high or low in humane orientation ( N = 876) and studied their relation to the traditional GLOBE scale and other cultural-level measures (agreeableness, religiosity, authoritarianism, and welfare state score). Findings revealed a strong correlation between humane orientation and agreeableness, welfare state score, and religiosity. Out-group humane orientation proved to be the more relevant subfacet of the original humane orientation construct, suggesting that future research on humane orientation should make use of this measure instead of the vague original scale. The ambivalent character of out-group humane orientation is displayed in its positive correlation to high authoritarianism. Patriotism was used as a control variable for noncritical acceptance of one’s society but did not change the correlations. Our findings are discussed as an example of how rigid expectations and a lack of tolerance for diversity may help explain the ambivalent nature of humane orientation.
Does Occupational Mobility Influence Health among Working Women? Comparing Objective and Subjective Measures of Work Trajectories
Authors: Wilkinson Lindsay R. , Shippee Tetyana P. , Ferraro Kenneth F.
Published: November 2012

Occupational mobility is highly valued in American society, but is it consequential to women’s health? Previous studies have yielded inconsistent results, but most measured occupational mobility by identifying transitions across occupational categories. Drawing from cumulative inequality theory, this study (1) compares objective and subjective measures of work trajectories and (2) examines the contributions of each to self-rated health. With 36 years of data from the National Longitudinal Survey of Mature Women (1967-2003), growth curve models are used to estimate the effects of middle-aged work trajectories on health among 2,503 U.S. women. Work trajectories as measured by the Duncan Socioeconomic Index predict health, but not after adjustment for perceived work trajectories and status characteristics. The findings reveal that subjective measures of occupational mobility provide important information for assessing health consequences of work transitions and that downward occupational mobility in middle age is deleterious to women’s health in later life.
Mixed Drinks and Mixed Messages
Authors: Livingston Jennifer A. , Bay-Cheng Laina Y. , Hequembourg Amy L. , Testa Maria , Downs Julie S.
Published: November 2012

Experimentation with alcohol and sexuality is a normative aspect of adolescent development. Yet, both present distinct risks to adolescent females and are especially problematic when they intersect. Although youth are often cautioned about the dangers associated with having sex and using alcohol, popular entertainment media frequently depict the combination of alcohol and sexuality as carefree fun. It is unclear how adolescent females interpret these contradictory messages in their everyday lives. Focus group interviews were used to explore young women’s understandings of the relation between alcohol and heterosexual sexuality. Young women, aged 14–17 years ( N = 97; 61% White), and their mothers were recruited through advertisements in local newspapers to participate in separate, simultaneous focus group interviews. Only data from the 15 daughters’ groups are presented here. Qualitative analysis revealed that participants recognized the risks associated with combining alcohol and sex; yet, they also perceived sexual advantages to drinking alcohol. Advantages included facilitating social and sexual interactions and excusing unsanctioned sexual behavior. Alcohol was also seen as increasing the likelihood of sexual regret and coercion through impaired judgment and self-advocacy abilities. Educational and prevention efforts need to consider adolescent developmental and social needs, as well as the influences of the larger cultural context in which youth function.
Magnetic Resonance Imaging Analysis of Rotational Alignment in Patients With Patellar Dislocations
Authors: Diederichs Gerd , Köhlitz Torsten , Kornaropoulos Evgenios , Heller Markus O. , Vollnberg Bernd , Scheffler Sven
Published: November 2012

Background:

The role of anatomic risk factors in patellofemoral instability is not yet fully understood, as they have been observed in patients either alone or in combination and in different degrees of severity.

Purpose:

To prospectively analyze rotational limb alignment in patients with patellofemoral instability and in controls using magnetic resonance imaging (MRI).

Study Design:

Cross-sectional study; Level of evidence, 3.

Methods:

Thirty patients (mean age, 22.9 y; range, 12-41 y) with a history of patellar dislocation and 30 age- and sex-matched controls (mean age, 25.2 y; range, 16-37 y) were investigated. The patients underwent MRI of the leg at 1.5 T using a peripheral angiography coil and a T2-weighted half-Fourier acquisition single-shot turbo spin echo (HASTE) sequence for measuring femoral antetorsion, tibial torsion, knee rotation, and mechanical axis deviation (MAD). The mean values of these parameters were compared between patients and controls. In addition, the patients underwent an assessment to determine the influence of rotational limb alignment on lateral trochlear inclination, trochlear facet asymmetry, trochlear depth, Insall-Salvati index, and tibial tuberosity–trochlear groove distance.

Results:

Patients had 1.56-fold higher mean femoral antetorsion (20.3° ± 10.4° vs 13.0° ± 8.4°; P < .01) and 1.6-fold higher knee rotation (9.4° ± 5.0° vs 5.7° ± 4.3°; P < .01) compared with controls. Moreover, patients had 2.9 times higher MAD (0.81 ± 0.75 mm vs −0.28 ± 0.87 mm; P < .01). Differences in tibial torsion were not significant. Also, there were no significant correlations between parameters of rotational alignment and standard anatomic risk factors.

Conclusion:

Our results suggest that some patients with nontraumatic patellar instability have greater internal femoral rotation, greater knee rotation, and a tendency for genu valgum compared with healthy controls. Rotational malalignment may be a primary risk factor in patellar dislocation that has so far been underestimated.