bluuebunny/crossref_metadata_2025 huggingface dataset:
Pre-Vaccination COVID-19 Vaccine Literacy in a Croatian Adult Population: A Cross-Sectional Study
Authors: Gusar Ivana , Konjevoda Suzana , Babić Grozdana , Hnatešen Dijana , Čebohin Maja , Orlandini Rahela , Dželalija Boris
Published: July 2021

Despite world-level efforts and the endeavors of scientists and medical professionals in suppressing the COVID-19 pandemic, inadequate levels of vaccine literacy of the general population can represent a grave obstacle. The aim of this study was to evaluate COVID-19 vaccine literacy in the Croatian adult general population before vaccination began. The specific objectives were to test differences regarding socio-demographic characteristics and to examine perceptions and attitudes about vaccination against COVID-19 considering the level of VL against COVID-19. A cross-sectional study with a translated and psychometrically tested questionnaire was conducted in 1227 participants before the start of vaccination, from 15 to 31 January 2021. The results show a medium level of vaccine literacy (M = 2.37, SD = 0.54) and a significant difference between functional and interactive-critical vaccine literacy (p < 0.001). The level of vaccine literacy grew with the level of education (p = 0.031) and reduced with age (p < 0.001). Participants who were employed, had chronic diseases, took medicine, or consumed alcohol daily had a lower level of vaccine literacy. There is room for progress in the COVID-19 VL level for the adult population in Croatia, especially at the interactive-critical VL, which could have an important role in people accepting the vaccine against the COVID-19 disease. A satisfactory level of vaccine literacy in the population is necessary because it can contribute to the fight against the pandemic.
Gait Flexibility among Older Persons Significantly More Impaired in Fallers Than Non-Fallers—A Longitudinal Study
Authors: Ekvall Hansson Eva , Valkonen Elina , Olsson Möller Ulrika , Chen Lin Yi , Magnusson Måns , Fransson Per-Anders
Published: July 2021

Gait disorders are a relevant factor for falls and possible to measure with wearable devices. If a wearable sensor can detect differences in gait parameters between fallers and non-fallers has not yet been studied. The aim of this study was to measure and compare gait parameters, vestibular function, and balance performance between fallers and non-fallers among a group of older persons. Participants were senior members (n = 101) of a Swedish non-profit gymnastic association. Gait parameters were obtained using an inertial measurement unit (IMU) that the participants wore on the leg while walking an obstacle course and on an even surface. Vestibular function was assessed by the Head-shake test, the Head impulse test, and the Dix–Hallpike maneuver. Balance was assessed by the Timed Up and Go, the Timed Up and Go manual, and the Timed Up and Go cognitive tests. Falls during the 12-month follow-up period were monitored using fall diaries. Forty-two persons (41%) had fallen during the 12-month follow-up. Fallers had more limited ability to vary their gait (gait flexibility) than non-fallers (p < 0.001). No other differences between fallers and non-fallers were found. The use of gait flexibility, captured by an IMU, seems better for identifying future fallers among healthy older persons than Timed Up and Go or Timed Up and Go combined with a cognitive or manual task.
Diversity, Complexity and Ordinality: Mental Health Services Outside the Institutions—Service Users’ and Professionals’ Experience-Based Practices and Knowledges, and New Public Management
Authors: Topor Alain , Matscheck David
Published: July 2021

In conjunction with the dismantling of psychiatric hospitals, social workers have been commissioned to help service users in their daily living in their homes and in the community. The consequences of these changes for experience-based knowledge and practices in their contexts remain relatively unknown. In this study, eighteen service users and the social workers they described as helpful for them were interviewed. The interviews were recorded, transcribed, and analyzed using Thematic Analysis. The following themes emerged: “Here, there and everywhere”, “Doing, being, becoming”, “Talking” and “Order, planning and improvisation” concerning the contradictions service users and professionals mentioned about their practices and the conditions imposed by managerial methods connected to New Public Management. Finally, “Spontaneous planned complexity” was chosen as our overarching theme to characterize the new knowledge and practices which have been developed. The displacement of the place for the encounter and the introduction of non-medicalized professions have allowed community-based practices and thus the co-creation and emergence of new knowledge about the service users as persons and the professionals as qualified professionals. The challenge remains for managers to have trust in their colleagues and not impose rigid rules, schematized methods, and repeated controls.
Maternal Anxiety, Infant Stress, and the Role of Live-Performed Music Therapy during NICU Stay in The Netherlands
Authors: Kraft Karianne E. , Jaschke Artur C. , Ravensbergen Anne-Greet , Feenstra-Weelink Annet , van Goor Maud E. L. , de Kroon Marlou L. A. , Reijneveld Sijmen A. , Bos Arend F. , van Dokkum Nienke H.
Published: July 2021

Having an infant in the neonatal intensive care unit (NICU) elicits maternal anxiety, which may hamper parent−child bonding. We performed a prospective cohort study to describe anxiety in mothers of infants born before 30 weeks of gestation during NICU stay in The Netherlands, and investigated the influence of infant stress and gestational age. Second, we performed a randomized-controlled live-performed music therapy trial (LPMT trial) to investigate whether music therapy applied to the infant alleviated maternal anxiety. The relation between infant stress, gestational age, and maternal anxiety was measured in 45 mother−infant dyads, using the Neonatal Infant Stressor Scale and the State-Trait Anxiety Inventory (STAI). The effect of LPMT on anxiety was assessed in 21 mothers whose infants were assigned to either LPMT (n = 12) or waitlist (n = 9). Mothers completed the STAI before and after this period. Maternal anxiety decreased over time in all mothers, and was strongly related with infant stress (r = 0.706, p < 0.001), but not with gestational age. Anxiety scores decreased by 12% after LMPT, and increased by 1% after a waitlist period (p = 0.30). Our results indicate that LPMT in the weeks after birth may accelerate the reduction of maternal anxiety. Further research should focus on the effects on mother−child bonding.
Income Inequality and Obesity among US Adults 1999–2016: Does Sex Matter?
Authors: Zare Hossein , Gaskin Danielle D. , Thorpe Roland J.
Published: July 2021

Obesity is a major public health problem that varies by income and sex, yet there is little evidence to determine the association between income inequality and obesity. We examined the association between income and obesity in adults ages 20 years and older and tested whether this relationship differs by sex in the United States. We used the 1999–2016 National Health and Nutrition Examination Survey (NHANES). We defined obesity if the body mass index was ≥30 kg/m2, and calculated the Gini coefficient (GC) to measure income inequality by using the Poverty Income Ratio. We examined the association between income and obesity using a Modified Poisson regression in a sample of 36,665 adults. We adjusted the models according to age, racial/ethnic groups, marital status, education, health behaviors, health insurance, self-reported health, and household structure. The association between income and obesity was consistently more significant among middle-income quintile and higher-income quintile men than among lower-income quintile men. The same association was not found for women; women in the highest income quintile were less likely to suffer from obesity than among lower-income quintile women. Our results suggest that policymakers should consider strategies to reduce structural inequality and encourage access to healthy foods and community-supported agricultural programs as nutritional interventions in low-income population settings.
Influence of the Tertile of Birth on Anthropometric Variables, Anaerobic Parameters and Quantitative Muscle Ultrasound in School Children
Authors: García Juan Carlos Giraldo , Hernández-Hernández Elena
Published: July 2021

The relative age effect (RAE) has been studied and demonstrated in the literature. Our study evaluated the influence of birth tertile on anthropometric variables, anaerobic parameters, and quantitative muscle ultrasound in school children. A transversal, comparative, non-randomized study was conducted with 159 participants (9.36 ± 0.84 years) recruited by purposive sampling, of whom 70 were girls (9.50 ± 0.77 years) and 89 were boys (9.25 ± 0.88 years). The sample was divided into groups based on the year of birth, and each group was divided into tertiles. The anthropometric parameters of body weight, height, and fat percentage were measured, and then a right quadriceps ultrasound was performed, followed by the evaluation of CMJ and continuous jumps. Comparison of tertile subgroups showed significant differences in the vertical jump, in girls (CMJ, PCMJ, PCMJR, PCMJDE, PCMJDER, and PP15) and in boys (PCMJ, PCMJR, PCMJDE, and PP15). The results indicate that being born in the first months of the year may have a positive influence on performance in anaerobic tests, such as vertical jump, and on the quantitative ultrasound results of the quadriceps.
Urinary Incontinence in Adulthood in a Course of Ectopic Ureter—Description of Two Clinical Cases with Review of Literature
Authors: Kuliniec Iga , Mitura Przemysław , Płaza Paweł , Widz Damian , Sudoł Damian , Godzisz Michał , Kołodyńska Aleksandra , Monist Marta , Wisz Agata , Bar Krzysztof
Published: July 2021

Urinary tract pathologies are the most common congenital abnormalities. Duplex colleting system occurs at different stages of completion and is usually asymptomatic. Ureteral ectopia is an associated anomaly which may manifest as continuous incontinence. The aim of this article is to present two patients with duplex kidney and ureteral ectopia. Both patients presented symptoms of continuous urinary incontinence and became symptomatic in the adult life.
Relationship between Musculoskeletal Disorders and Work Performance of Nursing Staff: A Comparison of Hospital Nursing Departments
Authors: Ou Yang-Kun , Liu Yi , Chang Yu-Ping , Lee Bih-O
Published: July 2021

This study aimed to explore the relationship between musculoskeletal disorders and the work performance of nursing staff. This cross-sectional study used the Checklist for Musculoskeletal Disorders (MSDs), the Nordic Musculoskeletal Questionnaire (NMQ), and the Work Ability Index to survey the prevalence of MSDs, as well as to determine the impact of MSDs on 117 nursing staff working in an emergency department, an intensive care unit, and general wards. The findings indicate that the nursing staff were exposed to a workplace environment with a high risk of MSDs. Nursing staff in the emergency department were at a particularly high risk of MSDs in their upper and lower limbs, while those working in the intensive care unit had a particularly high risk of injuries caused by manual material handling. Analyzing the relationship between MSD risk factors and NMQ scores showed a 6 times, 3.25 times, and 2.28 times increase in MSD conditions with a high workload compared to a low workload in the hand and wrist, the lower back or waist, and the knee, respectively. Medium and high workloads were found to increase the risk of MSD, which in turn affected the work ability of the nurses.
Marital Adjustment in Patients with Cancer: Association with Psychological Distress, Quality of Life, and Sleep Problems
Authors: Ruiz-Marin Carmen Maria , Molina-Barea Rocio , Slim Mahmoud , Calandre Elena P.
Published: July 2021

Marital adjustment plays a key role in the physical and psychosocial wellbeing. We conducted a cross-sectional study to evaluate marital adjustment and its association with psychological distress, suicidal ideation, sleep problems, and quality of life in patients with cancer. We collected demographic and clinical information using a structured survey. We assessed marital adjustment, quality of life, psychological distress profile, and sleep problems of participants using validated instruments: the Locke and Wallace Marital Adjustment Test (LWMAT), the Short-Form Health Survey-12, the Beck’s Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), and the Insomnia Severity Index (ISI). Suicidal ideation was assessed with item nine of the BDI. Of the 130 patients (52.3% females, mean age 57.9 ± 12.4 years) enrolled, 20 (15%) were classified as experiencing poor marital adjustment. Moderate to severe depression, anxiety, and insomnia were found in 25.4%, 34.6%, and 24.7% of participants, respectively. Positive suicidal ideation was documented in 13.8% of participants. We found a significant association between poor marital adjustment and depression, anxiety, suicidal ideation, and poor sleep. Our study confirms the relevance of marital adjustment in relation to the psychological wellbeing of patients with cancer. Depression, anxiety, and poor sleep were found to be significantly associated with poor marital adjustment.
Analysis of Physiological Response during Cardiopulmonary Resuscitation with Personal Protective Equipment: A Randomized Crossover Study
Authors: Fernández-Méndez María , Otero-Agra Martín , Fernández-Méndez Felipe , Martínez-Isasi Santiago , Santos-Folgar Myriam , Barcala-Furelos Roberto , Rodríguez-Núñez Antonio
Published: July 2021

The use of personal protective equipment (PPE) is required for the self-protection of healthcare workers during cardiopulmonary resuscitation (CPR) in patients at risk of aerosol transmission of infectious agents. The aim of this study was to analyze the impact of personal protective equipment on physiological parameters during CPR. A randomized, quasi-experimental, crossover design was used. The study was carried out in a training and simulation emergency box and the total sample consisted of 20 healthcare professionals. Two CPR tests were compared with the recommended sequence of 30 chest compressions and 2 ventilations. The duration of each test was 20 min. One of the CPR tests was carried out without using any PPE (CPR_control), i.e., performed with the usual clothing of each rescuer. The other test was carried out using a CPR test with PPE (i.e., CPR_PPE). The main variables of interest were: CPR quality, compressions, ventilations, maximum heart rate, body fluid loss, body temperature, perceived exertion index, comfort, thermal sensation and sweating. The quality of the CPR was similar in both tests. The maximum heart rate was higher in the active intervals (compressions + bag-valve-mask) of the test with PPE. CPR_PPE meant an increase in the perceived effort, temperature at the start of the thermal sensation test, thermal comfort and sweating, as opposed to CPR performed with usual clothing. Performing prolonged resuscitation with PPE did not influence CPR quality, but caused significant physiological demands. Rescuers were more fatigued, sweated more and their thermal comfort was worse. These results suggest that physical preparation should be taken into account when using PPE and protocols for physiological recovery after use should also be established.
The Impact of Land-Based Physical Activity Interventions on Self-Reported Health and Well-Being of Indigenous Adults: A Systematic Review
Authors: Ahmed Fatima , Zuk Aleksandra M. , Tsuji Leonard J.S.
Published: July 2021

For many Indigenous communities, decreased participation in traditional land-based activities has led to higher rates of chronic disease and a decrease in well-being. This systematic review explores how traditional land-based activities impact self-reported health and well-being of Indigenous adults, using Indigenous and Western perspectives. A search of three electronic databases (PubMed, Scopus, and Web of Science) identified nine studies which explored the experiences and perspectives of Indigenous adults taking part in land-based subsistence and ceremonial activities. A thematic analysis of these studies identified many interconnected physical, spiritual, mental, emotional, and community benefits. Community engagement throughout all stages of the interventions was an important factor in effectively addressing challenges and barriers stemming from colonization, decreased knowledge transfer, and increased use of technology. Participants reported developing more effective stress management techniques, a greater awareness of modifiable risk factors along with increased engagement with Elders. Ultimately, land-based subsistence and ceremonial activities were identified as playing an influential role in the lives of Indigenous adults. The involvement of community members allowed for the development of more culturally relevant interventions. Future community-specific research is needed to increase engagement in traditional physical-activities, improve well-being and overall reduce the risk of chronic disease.
Effects of Mobile Phone Use on Driving Performance: An Experimental Study of Workload and Traffic Violations
Authors: Ortega Carlos A. Catalina , Mariscal Miguel A. , Boulagouas Wafa , Herrera Sixto , Espinosa Juan M. , García-Herrero Susana
Published: July 2021

The use of communication technologies, e.g., mobile phones, has increased dramatically in recent years, and their use among drivers has become a great risk to traffic safety. The present study assessed the workload and road ordinary violations, utilizing driving data collected from 39 young participants who underwent a dual-task while driving a simulator, i.e., respond to a call, text on WhatsApp, and check Instagram. Findings confirmed that there are significant differences in the driving performance of young drivers in terms of vehicle control (i.e., lateral distance and hard shoulder line violations) between distracted and non-distracted drivers. Furthermore, the overall workload score of young drivers increases with the use of their mobile phones while driving. The obtained results contribute to a better understanding of the driving performance of distracted young drivers and thus they could be useful for further improvements to traffic safety strategies.
A Machine Learning Approach for Investigating Delirium as a Multifactorial Syndrome
Authors: Ocagli Honoria , Bottigliengo Daniele , Lorenzoni Giulia , Azzolina Danila , Acar Aslihan S. , Sorgato Silvia , Stivanello Lucia , Degan Mario , Gregori Dario
Published: July 2021

Delirium is a psycho-organic syndrome common in hospitalized patients, especially the elderly, and is associated with poor clinical outcomes. This study aims to identify the predictors that are mostly associated with the risk of delirium episodes using a machine learning technique (MLT). A random forest (RF) algorithm was used to evaluate the association between the subject’s characteristics and the 4AT (the 4 A’s test) score screening tool for delirium. RF algorithm was implemented using information based on demographic characteristics, comorbidities, drugs and procedures. Of the 78 patients enrolled in the study, 49 (63%) were at risk for delirium, 32 (41%) had at least one episode of delirium during the hospitalization (38% in orthopedics and 31% both in internal medicine and in the geriatric ward). The model explained 75.8% of the variability of the 4AT score with a root mean squared error of 3.29. Higher age, the presence of dementia, physical restraint, diabetes and a lower degree are the variables associated with an increase of the 4AT score. Random forest is a valid method for investigating the patients’ characteristics associated with delirium onset also in small case-series. The use of this model may allow for early detection of delirium onset to plan the proper adjustment in healthcare assistance.
How to Use Questionnaire Results in Psychosocial Risk Assessment: Calculating Risks for Health Impairment in Psychosocial Work Risk Assessment
Authors: Dettmers Jan , Stempel Christiane R.
Published: July 2021

Psychosocial risk questionnaires are common instruments in occupational safety and health promotion. Organizations use psychosocial risk questionnaires to obtain an economic overview of psychological job stressors and job resources. However, the procedures to assess if a result for a given workplace group is critical and calls for further action differ significantly and are often based on an arbitrary rule of thumb instead of empirically based evaluations. This article presents a method to translate questionnaire results into risk values for the occurrence of health impairment. We test this method on a dataset including the job stressors, job resources, and emotional exhaustion of 4210 employees from different industries. We applied logistic regression analysis to calculate the risks for impaired psychological health, indicated by high values of the burnout indicator emotional exhaustion. The results indicate significantly different health impairment risks (probabilities) for different scores on the job stressors and job resources scales as well as for scale score combinations. The risk values can be used to define cutoff values between high- and low-risk workplaces that are empirically based on stressor–strain relationships and are easily understandable by all stakeholders in the psychosocial risk assessment process, including laypersons.
One p-Factor for All? Exploring the Applicability of Structural Models of Psychopathology within Subgroups of a Population
Authors: Haywood Darren , Baughman Frank D. , Mullan Barbara A. , Heslop Karen R.
Published: July 2021

Structural models of psychopathology have emerged as an alternative to traditional categorical approaches. The bifactor model, which incorporates a general p-factor, has become the preferred structure. The p-factor is claimed to represent a substantive construct or property of the system; however, recent evidence suggests that it may be without substantive meaning. If a universal substantive p, and associated specific factors, is to be developed they not only must be applicable and consistent between populations but also must be applicable and consistent within subgroups of a population. This consistency needs to include not only factor loadings but also factor correlates. We used a simulated data approach to explore the applicability and consistency of four popular models of psychopathology to a range of heterogeneous subgroups and examined the consistency of their neurocognitive correlates. We found that only eight out of sixty-three subgroups fitted any of the models with all significant loadings, no negative loadings, no non-positive-definite identification issues, and no negative variance. All eight of these subgroups fit the correlated factors model, none fit the original bifactor model, four subgroups fit the revised bifactor model, and one subgroup fit the single-factor model. Correlates of the factors also varied substantially between the subgroups fitted to the same model. We discuss the implications of the findings, including the implications for the development of universal substantive factors of psychopathology.
Workaholism Prevention in Occupational Medicine: A Systematic Review
Authors: Cossin Thomas , Thaon Isabelle , Lalanne Laurence
Published: July 2021

Introduction: Given the extent of workaholism identified in the literature, it seems essential to consider effective preventive measures. The purpose of this article is to summarize literature data on possible collective and individual preventive measures against workaholism, especially in occupational medicine. Method: We conducted a systematic literature review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: 155 articles were retrieved in March 2019, but only 15 well-designed studies providing concrete measures to prevent workaholism were included. The various measures were classified using the traditional distinction between three levels of prevention. At the first level of prevention, workaholism can be avoided by implementing a protective organizational culture. The second level of prevention rather focuses on individual training and counselling to address the negative consequences of workaholism. Finally, the third level of prevention combines cognitive and behavioral interventions that enable professional and social reintegration of workaholics. Discussion: This literature review confirms the multifactorial origin of workaholism and the involvement of organizational factors, supporting the necessary contribution of companies in its prevention. This review also reinforces the growing perception of workaholism as a behavioral addiction. Occupational physicians play a key role in this preventive approach as they can influence both working conditions and individual care. The highlighted preventive measures seem to be not only favorable to workaholics, but also to companies. Conclusion: This review provides field tools that can be used at the various levels of workaholism prevention. Nevertheless, intervention studies are required to confirm the effectiveness of the measures presented.
Telemedicine as a Therapeutic Option in Sports Medicine: Results of a Nationwide Cross-Sectional Study among Physicians and Patients in Germany
Authors: Hertling Stefan , Loos Franziska Maria , Graul Isabel
Published: July 2021

Background: Worldwide, the number of treatments in the field of sports medicine is increasing. However, the COVID-19 pandemic has changed everyday life. Many consultations had to be cancelled, postponed, or converted to a virtual format. Telemedicine in sports medicine could support physicians. This study analyzes the use and perception of telemedicine applications among physicians and patients in the field of sports medicine in Germany. Methods: This prospective cross-sectional study was based on a survey of sports medicine physicians and patients in Germany during the COVID-19 pandemic. Descriptive statistics were calculated. Results: We analyzed the responses of 729 patients and 702 sports medicine physicians. Most believed that telemedicine is useful. Both physicians and patients rated their knowledge of telemedicine as unsatisfactory. The majority of respondents said they do not currently use telemedicine but would like to do so. Patients and physicians reported that their attitude had changed positively towards telemedicine and that their usage had increased due to COVID-19. The majority in both groups agreed on implementing virtual visits in stable disease conditions. Telemedicine was considered helpful for follow-up monitoring and prevention by both groups. Conclusion: Telemedicine in sports medicine has seen limited use but is highly accepted among physicians and patients alike. The absence of a structured framework is an obstacle to effective implementation. Training courses should be introduced to improve the limited knowledge regarding the use of telemedicine. More research in telemedicine in sports medicine is needed. This includes large-scale randomized controlled trials, economic analyses and explorations of user preferences.
Assessment of Spatio-Temporal Variation and Driving Mechanism of Ecological Environment Quality in the Arid Regions of Central Asia, Xinjiang
Authors: Bi Xu , Chang Bianrong , Hou Fen , Yang Zihan , Fu Qi , Li Bo
Published: July 2021

Grassland ecosystems are increasingly threatened by pressures from climate change and intensified human activity, especially in the arid region of Central Asia. A comprehensive understanding of the ecological environment changes is crucial for humans to implement environmental protection measures to adapt to climate change and alleviate the contradiction between humans and land. In this study, fractional vegetation coverage (FVC), leaf area index (LAI), gross primary productivity of vegetation (GPP), land surface temperature (LST), and wetness (WET) were retrieved from Moderate-Resolution Imaging Spectroradiometer (MODIS) satellite remote sensing products in 2008 and 2018. Principal component analysis (PCA) was used to establish the MODIS data-based ecological index (MODEI) in the study area, and the spatial differentiation characteristics and driving mechanism of ecological quality in the last ten years were explored. The results showed that: (1) FVC, GPP, LAI, and WET had positive effects on the ecological environment, while LST had a negative impact on the ecological environment. FVC and GPP were more significant than other indicators. (2) The MODEI showed a spatial pattern of “excellent in the north and poor in the south” and changed from north to south in the study area. (3) From 2008 to 2018, the average MODEI of Fuyun County increased from 0.292 to 0.303, indicating that the ecological quality in Fuyun County became better overall. The improved areas were mainly located in the summer pastures at higher elevations. In comparison, the deteriorated areas were concentrated in the spring and autumn pastures and winter pastures at lower elevations. The areas where the ecological environment had obviously improved and degraded were distributed along the banks of the Irtysh River and the Ulungur River. (4) With the increase in precipitation and the decrease in grazing pressure, the MODEI of summer pasture was improved. The deterioration of ecological environment quality in spring and autumn pastures and winter pastures was related to the excessive grazing pressure. The more significant changes in the MODEI on both sides of the river were associated with implementing the herdsmen settlement project. On the one hand, the implementation of newly settled villages increased the area of construction land on both sides of the river, which led to the deterioration of ecological quality; on the other hand, due to the increase in cropland land and the planting of artificial grasses along the river, the ecological quality was improved. The study offers significant information for managers to make more targeted ecological restoration efforts in ecologically fragile areas.
Evaluating Effectiveness of YouTube Videos for Teaching Medical Students CPR: Solution to Optimizing Clinician Educator Workload during the COVID-19 Pandemic
Authors: Nomura Osamu , Irie Jin , Park Yoonsoo , Nonogi Hiroshi , Hanada Hiroyuki
Published: July 2021

(1) Background: This study aimed to evaluate the effectiveness of using a pre-existing video on CPR to support preclinical resuscitation education for medical students; (2) Methods: In total, 129 students selected to learn CPR using a pre-existing YouTube video or the conventional screencast video by their university faculties. All students responded to the pre- and post-training multiple-choice questionnaire on the basic knowledge of CPR, and, based on their responses, an analysis of covariance (ANCOVA) was conducted to assess the comparability of effectiveness across learning modalities. (3) Results: Among the students, 49 (38.0%) students selected the YouTube video to learn about CPR and were treated as the intervention group. The mean pre-test scores and post-test scores of the YouTube and the instructor’s video groups were 6.43 and 6.64, and 9.06 and 9.09, respectively. After controlling for the pre-test score effects, the results of ANCOVA did not show statistically significant differences between groups (p = 0.927), indicating comparable performance between groups that used YouTube and the instructor’s videos. (4) Conclusion: Utilizing YouTube videos is a useful teaching strategy for teaching CPR knowledge, which would reduce the burden on faculty of creating screencast lecture videos for online learning on resuscitation.
Leaving No Child Behind: Decomposing Socioeconomic Inequalities in Child Health for India and South Africa
Authors: Alaba Olufunke A. , Hongoro Charles , Thulare Aquina , Lukwa Akim Tafadzwa
Published: July 2021

Background: The United Nations’ 2030 Agenda for Sustainable Development argues for the combating of health inequalities within and among countries, advocating for “leaving no one behind”. However, child mortality in developing countries is still high and mainly driven by lack of immunization, food insecurity and nutritional deficiency. The confounding problem is the existence of socioeconomic inequalities among the richest and poorest. Thus, comparing South Africa’s and India’s Demographic and Health Surveys (DHS) of 2015/16, this study examines socioeconomic inequalities in under-five children’s health and its associated factors using three child health indications: full immunization coverage, food insecurity and malnutrition. Methods: Erreygers Normalized concentration indices were computed to show how immunization coverage, food insecurity and malnutrition in children varied across socioeconomic groups (household wealth). Concentration curves were plotted to show the cumulative share of immunization coverage, food insecurity and malnutrition against the cumulative share of children ranked from poorest to richest. Subsequent decomposition analysis identified vital factors underpinning the observed socioeconomic inequalities. Results: The results confirm a strong socioeconomic gradient in food security and malnutrition in India and South Africa. However, while full childhood immunization in South Africa was pro-poor (−0.0236), in India, it was pro-rich (0.1640). Decomposed results reported socioeconomic status, residence, mother’s education, and mother’s age as primary drivers of health inequalities in full immunization, food security and nutrition among children in both countries. Conclusions: The main drivers of the socioeconomic inequalities in both countries across the child health outcomes (full immunization, food insecurity and malnutrition) are socioeconomic status, residence, mother’s education, and mother’s age. In conclusion, if socioeconomic inequalities in children’s health especially food insecurity and malnutrition in South Africa; food insecurity, malnutrition and immunization in India are not addressed then definitely “some under-five children will be left behind”.
Participatory Development Process of Two Human Dimension Intervention Programs to Foster Physical Fitness and Psychological Health and Well-Being in Wildland Firefighting
Authors: Leduc Caleb , Giga Sabir I. , Fletcher Ian J. , Young Michelle , Dorman Sandra C.
Published: July 2021

Intervention programs designed, delivered, and evaluated by and within organizations are a critical component in the promotion of employee health and well-being and in the prevention of occupational injury. Critical for transference of findings across complex occupational settings is a clearly articulated development process, a reliance on and evaluation of underlying theoretical foundations, and the inclusion of relevant outcomes emerging out of participatory action processes. To date, there have been no documented efforts outlining the development, implementation, or evaluation of human dimension intervention programs targeting wildland firefighters. The purpose of this paper is to outline the development of two collaborative and participatory intervention programs, targeting wildland firefighters’ physical and psychological health and well-being. Two human dimension intervention programs were developed in a collaborative, iterative and participatory process following the Context–Content–Process–Outcomes Framework. First, a physical fitness training intervention program was designed to maintain wildland firefighter’s physical fitness levels and attenuate risk of injury. Second, a psychosocial education intervention program was developed to mitigate the impact of psychosocial risk factors, foster work engagement, and decrease job stress. The current study provides evidence for the capacity of researchers and organizations to collaboratively develop practical programs primed for implementation and delivery.
Health by Words—A Content Analysis of Political Manifestos in the Portuguese Elections of 1975
Authors: Mourao Paulo
Published: July 2021

The elections of 25 April 1975 had the highest participation to date in the Portuguese democratic experience. The competing forces organized electoral manifestos that covered a wide range of topics, with complex resources and analysis of the economic problems and the development of the Portuguese space. However, these manifestos’ contents are rich, there has not been a proper effort to study these political messages and reflect on the supply of answers provided by the competing parties to the collective needs assumed by the population, especially regarding Portuguese health. This work reviews these contents through a content analysis methodology, with the conclusion that the most common themes were related to the socioeconomic rights of Portuguese citizens and the need to boost development of different regions and fields, especially health. Other themes that the parties took on as central issues were those related to the war in the overseas territory and the stabilization of the emerging democratic process.
Modelling Place Visit Probability Sequences during Trajectory Data Gaps Based on Movement History
Authors: Ren Chang , Tang Luliang , Long Jed , Kan Zihan , Yang Xue
Published: July 2021

The acquisition of human trajectories facilitates movement data analytics and location-based services, but gaps in trajectories limit the extent in which many tracking datasets can be utilized. We present a model to estimate place visit probabilities at time points within a gap, based on empirical mobility patterns derived from past trajectories. Different from previous models, our model makes use of prior information from historical data to build a chain of empirically biased random walks. Therefore, it is applicable to gaps of varied lengths and can be fitted to empirical data conveniently. In this model, long gaps are broken into a chain of multiple episodes according to past patterns, while short episodes are estimated with anisotropic location transition probabilities. Experiments show that our model is able to hit almost 60% of the ground truth for short gaps of several minutes and over 40% for longer gaps up to weeks. In comparison, existing models are only able to hit less than 10% and 1% for short and long gaps, respectively. Visit probability distributions estimated by the model are useful for generating paths in data gaps, and have potential for disaggregated movement data analysis in uncertain environments.
Multi-Gene Testing Overview with a Clinical Perspective in Metastatic Triple-Negative Breast Cancer
Authors: Dameri Martina , Ferrando Lorenzo , Cirmena Gabriella , Vernieri Claudio , Pruneri Giancarlo , Ballestrero Alberto , Zoppoli Gabriele
Published: July 2021

Next-generation sequencing (NGS) is the technology of choice for the routine screening of tumor samples in clinical practice. In this setting, the targeted sequencing of a restricted number of clinically relevant genes represents the most practical option when looking for genetic variants associated with cancer, as well as for the choice of targeted treatments. In this review, we analyze available NGS platforms and clinical applications of multi-gene testing in breast cancer, with a focus on metastatic triple-negative breast cancer (mTNBC). We make an overview of the clinical utility of multi-gene testing in mTNBC, and then, as immunotherapy is emerging as a possible targeted therapy for mTNBC, we also briefly report on the results of the latest clinical trials involving immune checkpoint inhibitors (ICIs) and TNBC, where NGS could play a role for the potential predictive utility of homologous recombination repair deficiency (HRD) and tumor mutational burden (TMB).
Dysregulation of miRNA in Leukemia: Exploiting miRNA Expression Profiles as Biomarkers
Authors: Anelli Luisa , Zagaria Antonella , Specchia Giorgina , Musto Pellegrino , Albano Francesco
Published: July 2021

Micro RNAs (miRNAs) are a class of small non-coding RNAs that have a crucial role in cellular processes such as differentiation, proliferation, migration, and apoptosis. miRNAs may act as oncogenes or tumor suppressors; therefore, they prevent or promote tumorigenesis, and abnormal expression has been reported in many malignancies. The role of miRNA in leukemia pathogenesis is still emerging, but several studies have suggested using miRNA expression profiles as biomarkers for diagnosis, prognosis, and response to therapy in leukemia. In this review, the role of miRNAs most frequently involved in leukemia pathogenesis is discussed, focusing on the class of circulating miRNAs, consisting of cell-free RNA molecules detected in several body fluids. Circulating miRNAs could represent new potential non-invasive diagnostic and prognostic biomarkers of leukemia that are easy to isolate and characterize. The dysregulation of some miRNAs involved in both myeloid and lymphoid leukemia, such as miR-155, miR-29, let-7, and miR-15a/miR-16-1 clusters is discussed, showing their possible employment as therapeutic targets.
Molecular Characterization of TRPA Subfamily Genes and Function in Temperature Preference in Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae)
Authors: Wang Xiao-Di , Lin Ze-Kai , Ji Shun-Xia , Bi Si-Yan , Liu Wan-Xue , Zhang Gui-Fen , Wan Fang-Hao , Lü Zhi-Chuang
Published: July 2021

To reveal the mechanism of temperature preference in Tuta absoluta, one of the top 20 plant pests in the world, we cloned and identified TaTRPA1, TaPain, and TaPyx genes by RACE and bioinformatic analysis, and clarified their expression profiles during different development stages using real-time PCR, and revealed their function in preference temperature by RNAi. The full-length cDNA of TaPain was 3136 bp, with a 2865-bp open reading frame encoding a 259.89-kDa protein; and the partial length cDNA of TaPyx was 2326-bp, with a 2025-bp open reading frame encoding a 193.16-kDa protein. In addition, the expression of TaTRPA1 and TaPyx was significantly lower in larvae than other stages, and it was significantly higher in pupae and newly emerging males for TaPain. After feeding target double-stranded RNA (dsRNA), the preferred temperature decreased 2 °C more than the control group. In conclusion, the results firstly indicated the molecular characterization of TRPA subfamily genes and their key role in temperature perception in T. absoluta, and the study will help us to understand the temperature-sensing mechanism in the pest, and will provide some basis for study of other Lepidoptera insects’ temperature preference. Moreover, it is of great significance in enriching the research progress of “thermos TRP”.
Human Radiosensitivity and Radiosusceptibility: What Are the Differences?
Authors: El-Nachef Laura , Al-Choboq Joelle , Restier-Verlet Juliette , Granzotto Adeline , Berthel Elise , Sonzogni Laurène , Ferlazzo Mélanie L. , Bouchet Audrey , Leblond Pierre , Combemale Patrick , Pinson Stéphane , Bourguignon Michel , Foray Nicolas
Published: July 2021

The individual response to ionizing radiation (IR) raises a number of medical, scientific, and societal issues. While the term “radiosensitivity” was used by the pioneers at the beginning of the 20st century to describe only the radiation-induced adverse tissue reactions related to cell death, a confusion emerged in the literature from the 1930s, as “radiosensitivity” was indifferently used to describe the toxic, cancerous, or aging effect of IR. In parallel, the predisposition to radiation-induced adverse tissue reactions (radiosensitivity), notably observed after radiotherapy appears to be caused by different mechanisms than those linked to predisposition to radiation-induced cancer (radiosusceptibility). This review aims to document these differences in order to better estimate the different radiation-induced risks. It reveals that there are very few syndromes associated with the loss of biological functions involved directly in DNA damage recognition and repair as their role is absolutely necessary for cell viability. By contrast, some cytoplasmic proteins whose functions are independent of genome surveillance may also act as phosphorylation substrates of the ATM protein to regulate the molecular response to IR. The role of the ATM protein may help classify the genetic syndromes associated with radiosensitivity and/or radiosusceptibility.
Structure and Function of Piezophilic Hyperthermophilic Pyrococcus yayanosii pApase
Authors: Jin Zheng , Wang Weiwei , Li Xuegong , Zhou Huan , Yi Gangshun , Wang Qisheng , Yu Feng , Xiao Xiang , Liu Xipeng
Published: July 2021

3’-Phosphoadenosine 5’-monophosphate (pAp) is a byproduct of sulfate assimilation and coenzyme A metabolism. pAp can inhibit the activity of 3′-phosphoadenosine 5′-phosphosulfate (PAPS) reductase and sulfotransferase and regulate gene expression under stress conditions by inhibiting XRN family of exoribonucleases. In metazoans, plants, yeast, and some bacteria, pAp can be converted into 5’-adenosine monophosphate (AMP) and inorganic phosphate by CysQ. In some bacteria and archaea, nanoRNases (Nrn) from the Asp-His-His (DHH) phosphoesterase superfamily are responsible for recycling pAp. In addition, histidinol phosphatase from the amidohydrolase superfamily can hydrolyze pAp. The bacterial enzymes for pAp turnover and their catalysis mechanism have been well studied, but these processes remain unclear in archaea. Pyrococcus yayanosii, an obligate piezophilic hyperthermophilic archaea, encodes a DHH family pApase homolog (PyapApase). Biochemical characterization showed that PyapApase can efficiently convert pAp into AMP and phosphate. The resolved crystal structure of apo-PyapApase is similar to that of bacterial nanoRNaseA (NrnA), but they are slightly different in the α-helix linker connecting the DHH and Asp-His-His associated 1 (DHHA1) domains. The longer α-helix of PyapApase leads to a narrower substrate-binding cleft between the DHH and DHHA1 domains than what is observed in bacterial NrnA. Through mutation analysis of conserved amino acid residues involved in coordinating metal ion and binding substrate pAp, it was confirmed that PyapApase has an ion coordination pattern similar to that of NrnA and slightly different substrate binding patterns. The results provide combined structural and functional insight into the enzymatic turnover of pAp, implying the potential function of sulfate assimilation in hyperthermophilic cells.
The Enigmatic Role of TP53 in Germ Cell Tumours: Are We Missing Something?
Authors: Ottaviano Margaret , Giunta Emilio , Rescigno Pasquale , Pereira Mestre Ricardo , Marandino Laura , Tortora Marianna , Riccio Vittorio , Parola Sara , Casula Milena , Paliogiannis Panagiotis , Cossu Antonio , Vogl Ursula , Bosso Davide , Rosanova Mario , Mazzola Brunello , Daniele Bruno , Palmieri Giuseppe , Palmieri Giovannella
Published: July 2021

The cure rate of germ cell tumours (GCTs) has significantly increased from the late 1970s since the introduction of cisplatin-based therapy, which to date remains the milestone for GCTs treatment. The exquisite cisplatin sensitivity has been mainly explained by the over-expression in GCTs of wild-type TP53 protein and the lack of TP53 somatic mutations; however, several other mechanisms seem to be involved, many of which remain still elusive. The findings about the role of TP53 in platinum-sensitivity and resistance, as well as the reported evidence of second cancers (SCs) in GCT patients treated only with surgery, suggesting a spectrum of cancer predisposing syndromes, highlight the need for a deepened understanding of the role of TP53 in GCTs. In the following report we explore the complex role of TP53 in GCTs cisplatin-sensitivity and resistance mechanisms, passing through several recent genomic studies, as well as its role in GCT patients with SCs, going through our experience of Center of reference for both GCTs and cancer predisposing syndromes.