bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Conserved, Computationally Predicted Epitope Regions for VP5 and VP7 Across three Orbiviruses
Authors: Russell Bonnie L , Parbhoo Nishal , Gildenhuys Samantha
Published: January 2018

Orbiviruses are double-stranded RNA viruses that have profound economic and veterinary significance, 3 of the most important being African horse sickness virus (AHSV), bluetongue virus (BTV), and epizootic hemorrhagic disease virus (EHDV). Currently, vaccination and vector control are used as preventative measures; however, there are several problems with the current vaccines. Comparing viral amino acid sequences, we obtained an AHSV-BTV-EHDV consensus sequence for VP5 (viral protein 5) and for VP7 (viral protein 7) and generated homology models for these proteins. The structures and sequences were analyzed for amino acid sequence conservation, entropy, surface accessibility, and epitope propensity, to computationally determine whether consensus sequences still possess potential epitope regions. In total, 5 potential linear epitope regions on VP5 and 11 on VP7, as well as potential discontinuous B-cell epitopes, were identified and mapped onto the homology models created. Regions identified for VP5 and VP7 could be important in vaccine design against orbiviruses.
Hodgkin Lymphoma: Differences in Treatment Between Europe and the United States/North America: Evolving Trends in Protocol Therapy
Authors: FitzGerald Thomas J , Bishop-Jodoin Maryann
Published: January 2018

With continued progress and success in clinical care, the management of patients with Hodgkin lymphoma (HL) has undergone continuous revision to improve patient care outcomes and limit acute and late treatment effects on normal tissue imposed by therapy. Hodgkin lymphoma is a disease that affects children, adolescents, and adults. Clinical management strategies are influenced by the patient’s age at diagnosis, tumor burden, response to induction therapy, and potential expectation of treatment impact on normal tissue. The approach to patient management varies in many parts of the world and is influenced by treatment availability, physician training, and medical culture. Differences in approach are important to understand for accurately comparing and contrasting outcome studies. In this article, we will identify current areas of common ground and points of separation in patient care management for HL. Opportunities for clinical trial strategies will be defined for future clinical trials.
Does subtitled television drama brand the nation? Danish television drama and its language(s) in Japan
Authors: Jacobsen Ushma Chauhan
Published: January 2018

This article explores the relationships between nation branding, authenticity, language and their ideologies by considering two themes. First, how language ideologies and language practices texture the transnational production, distribution and viewing of subtitled television drama. Second, the extent and ways by which subtitled television dramas, in languages other than English, brand the nation to which they are associated. Using the context of increasing exports of Danish television drama to other nations, the article draws its empirical material from fieldwork interactions with industry professionals and viewers in Japan to consider both themes. The article proposes that there are different intensities by which Danish television dramas brand Denmark and the Nordic region; it discusses the implications of the use of English, and how branding the nation involves processes that are intrinsically fragile and require symbiotic relations with other languages and other nations to be successful. This article forms part of the Theorizing Media in Nation Branding Special Issue.
The influence of knowledge recipients’ proactivity on knowledge construction in cooperative learning experiences
Authors: García-Almeida Desiderio Juan , Cabrera-Nuez María Teresa
Published: January 2018

Cooperative learning techniques in teaching activities are becoming increasingly popular. Many studies have documented the benefits of these techniques, but fewer have analysed the factors affecting students’ achievement. One of those factors could be the student’s proactivity, since cooperative techniques require active involvement of students. Proactivity or proactive behaviour relates to pioneering behaviour, initiative taken to exploit new opportunities, and a leading attitude. This study analyses the influence of several aspects related to students’ proactivity on knowledge construction in the context of cooperative learning. The aspects included in the proactivity framework are the student’s creativity, locus of control, self-effectiveness, and motivation towards cooperative learning. These variables and their potential effect on knowledge construction in cooperative experiences are discussed. The resulting hypotheses are tested with data from students who participated in a jigsaw, and the results show the positive impact of the internal locus of control and self-efficacy, along with the fact that the student is attending the course for the first time.
Cardiovascular diseases in patients receiving small molecules with anti-vascular endothelial growth factor activity: A meta-analysis of approximately 29,000 cancer patients
Authors: Totzeck Matthias , Mincu Raluca-Ileana , Mrotzek Simone , Schadendorf Dirk , Rassaf Tienush
Published: January 2018

Background

Targeted therapy with tyrosine kinase inhibitors with anti-vascular endothelial growth factor activity improves survival of cancer patients. Cardiovascular complications are critical and it is unknown whether these require specific treatment strategies. We aimed to clarify the associated risk of cardiovascular adverse events in patients treated with tyrosine kinase inhibitors.

Design

The design of this study was a meta-analysis of randomised controlled trials.

Methods

We searched PubMed, Cochrane, EMBASE and Web of Science databases for randomised controlled trials published until January 2017 that assessed patients with different types of cancer treated with or without tyrosine kinase inhibitors in addition to standard chemotherapy.

Results

A total of 29,252 patients from 71 randomised controlled trials were included. Tyrosine kinase inhibitor treatment was associated with a higher cardiac ischaemia relative risk (relative risk = 1.69; 95% confidence interval: 1.12–2.57; p = 0.01), with the highest risks observed for sorafenib and patients with renal cancer. Risk of thrombocytopaenia (relative risk = 2.2; 95% confidence interval: 1.73–2.79; p < 0.001) was highest for regorafenib and patients with breast cancer. Left ventricular systolic dysfunction was increased after tyrosine kinase inhibitor therapy (relative risk = 2.53; 95% confidence interval:1.79 – 3.57; p < 0.001), with the highest risks reported for sunitinib and hepatocellular cancer. QT corrected interval prolongation (relative risk = 6.25; 95% confidence interval: 3.44–11.38; p < 0.001) and arterial hypertension (relative risk = 3.78; 95% confidence interval: 3.15-4.54; p < 0.001) were reported. The relative risks of arterial adverse events, cerebral ischaemia, venous adverse events and pulmonary embolism were similar across groups.

Conclusion

Tyrosine kinase inhibitors increase the risk of severe cardiovascular and particularly thrombotic adverse events. Specific treatment regimens when prescribing tyrosine kinase inhibitor therapies appear desirable.
Factors associated with health-related quality of life in stable ambulatory congestive heart failure patients: Systematic review
Authors: Baert Anneleen , De Smedt Delphine , De Sutter Johan , De Bacquer Dirk , Puddu Paolo Emilio , Clays Els , Pardaens Sofie
Published: January 2018

Background

Since improved treatment of congestive heart failure has resulted in decreased mortality and hospitalisation rates, increasing self-perceived health-related quality of life (HRQoL) has become a major goal of congestive heart failure treatment. However, an overview on predictieve factors of HRQoL is currently lacking in literature.

Purpose

The aim of this study was to identify key factors associated with HRQoL in stable ambulatory patients with congestive heart failure.

Methods

A systematic review was performed. MEDLINE, Web of Science and Embase were searched for the following combination of terms: heart failure, quality of life, health perception or functional status between the period 2000 and February 2017. Literature screening was done by two independent reviewers.

Results

Thirty-five studies out of 8374 titles were included for quality appraisal, of which 29 were selected for further data extraction. Four distinct categories grouping different types of variables were identified: socio-demographic characteristics, clinical characteristics, health and health behaviour, and care provider characteristics. Within the above-mentioned categories the presence of depressive symptoms was most consistently related to a worse HRQoL, followed by a higher New York Heart Association functional class, younger age and female gender.

Conclusion

Through a systematic literature search, factors associated with HRQoL among congestive heart failure patients were investigated. Age, gender, New York Heart Association functional class and depressive symptoms are the most consistent variables explaining the variance in HRQoL in patients with congestive heart failure. These findings are partly in line with previous research on predictors for hard endpoints in patients with congestive heart failure.
Lidocaine 5%–medicated plaster (Versatis) for localised neuropathic pain: results of a multicentre evaluation of use in children and adolescents
Authors: Goddard John M , Reaney Rebecca L
Published: January 2018

The Lidocaine 5% plaster is licensed for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia in adult patients over 18 years of age. Studies in adults also demonstrate efficacy of Lidocaine 5% plasters in other neuropathic pain conditions. Case reports and experience suggested efficacy of Lidocaine 5% plasters in children and adolescents with localised neuropathic pain. Initiated by the Pain in Children Special Interest Group (PICSIG) of the British Pain Society, a 3-year prospective multicentre service evaluation was undertaken to document the usage and efficacy of the Lidocaine 5% plaster in paediatric patients being managed by paediatric pain teams in the United Kingdom. Five paediatric pain teams provided anonymised data pre-treatment and 3–6 months after commencing Lidocaine 5% plaster. Changes in pain score, function, sleep and continuing use were evaluated. Data were obtained for 115 patients; age range 5–18 years (mean: 12 years). Diagnosis and site of application varied. Benefit from use of a Lidocaine 5% plaster in an individual was deemed if two or more of the following were reported: reduction in pain score, functional improvement, sleep improvement and continuing use of Lidocaine 5% plaster. Benefit was recorded for 79 patients (69%); 32 patients were recorded as receiving no benefit and data were unavailable for 4 patients, and 7 patients reported minor skin reactions. This prospective service evaluation supports the efficacy of the Lidocaine 5% plaster in children and adolescents with localised neuropathic pain and confirms tolerability and safety. It is the opinion of the PICSIG of the British Pain Society that the Lidocaine 5% plaster should be considered early in the multidisciplinary management of localised neuropathic pain in children and adolescents.
Prevalence of oral human papillomavirus (HPV) in the adult population of Córdoba, Argentina
Authors: Criscuolo MI , Belardinelli PA , Morelatto RA , Mosmann J , Venezuela RF , Kiguen AX , Cuffini C , Lopez de Blanc S
Published: January 2018

Objective:

To determine the prevalence of oral human papillomavirus (HPV) in the population of Córdoba, Argentina and its association with other risk factors.

Methods:

A sample of 401 volunteers over 18 years, representative of Cordoba city population, was selected. Using a questionnaire, we collected sociodemographic data including the use of tobacco, alcohol, and mate consumption. Two biological samples were taken from each individual, whole mouth saliva and a scraping of the posterior border of the tongue. HPV was determined by polymerase chain reaction using MY09/11 primers. Statistical associations were analyzed using χ2 test.

Results:

Prevalence of HPV in the population was of 3% (13/401). The mean age of HPV-positive cases was 42 years with a range of 20–85; 54% were females. Among the 13 cases whose saliva was positive for HPV, only 7 (54%) had HPV-DNA in the tongue scraping. All identified genotypes were of low risk and HPV11 was the most frequent type in 62% of positive cases. None of the positive subjects exhibited oral lesions compatible with HPV infection. Ten (77%) of the HPV-positive subjects exhibited lesions in the oral mucosa, mostly related to chronic mechanical irritation (CMI) (odds ratio 3, 95% confidence interval: 1.01–8.97, p < 0.05). Fifty-four percent of HPV-positive individuals were light smokers and consumed alcohol moderately. The combination of both habits was observed in 31%. Sixty-two percent drank mate at high water temperatures. No differences were detected in the sexual behavior or in the reported number of sexual partners between HPV-positive and -negative subjects.

Conclusion:

The overall prevalence of oral HPV in adults was 3%; only the low-risk genotypes were detected and no association with other risk factors for oral cancer was found. However, an association with CMI of the oral mucosa was noted. The saliva sample proved to be a simple, efficient, and well-tolerated method suitable for screening for HPV, and more cases were detected in saliva compared with tissue scrapings.
Music genre induced driver aggression
Authors: Brodsky Warren , Olivieri Dana , Chekaluk Eugene
Published: January 2018

Few empirical studies have targeted the links between media delinquency or risk-promoting popular culture (specifically aversive music genres) with negative affective states and aggressive driving. Yet for over a decade, drivers have reported that they commit traffic violations while listening to loud fast-beat aggressive music styles. The current investigation seeks to explore aggressive driving behavior while considering the genre of music background. Most specifically, we look at aversive music styles and songs with violent lyrics. The article outlines the testimonials by drivers ( N = 6,058) from six recent commercially solicited surveys with drivers which demonstrate “proof of concept” for driver aggression subsequent to driving with music accompaniment. Further, the article details a study ( N = 50) employing a driving simulator with 30 paired music exemplars of 4 music genres. Half consisted of songs with hostile aggressive lyrics and half with neutral lyrics—both performed in the same music styles by the same artists. The results demonstrate that energetic music boosted excitement resulting in decreased lateral control, increased excursions from the lane, and an increased tendency to stray onto the hard shoulder. Drivers who were exposed to hostile music with violent content on the other hand demonstrated increased cruising speeds and a higher percentage of time exceeding speed limits. These differential effects of music on drivers can be referred to as either music-generated driver distraction or music genre induced driver aggression.
An Employee-Centered Care Model Responds to the Triple Aim: Improving Employee Health
Authors: Fox Kelly , McCorkle Ruth
Published: January 2018

Health care expenditures, patient satisfaction, and timely access to care will remain problematic if dramatic changes in health care delivery models are not developed and implemented. To combat this challenge, a Triple Aim approach is essential; Innovation in payment and health care delivery models is required. Using the Donabedian framework of structure, process, and outcome, this article describes a nurse-led employee-centered care model designed to improve consumers’ health care experiences, improve employee health, and increase access to care while reducing health care costs for employees, age 18 and older, in a corporate environment.
Use of Selective Serotonin Reuptake Inhibitor and Midodrine in a Patient With Autonomic Instability 2/2 Compressive Squamous Cell Carcinoma and Pain
Authors: Ball Kyle , Vacek Thomas P.
Published: January 2018

A rare cause of reflex syncope is metastatic cancers involving the head and neck. These can irritate the glossopharyngeal nerve and lead to glossopharyngeal neuralgia with associated syncope. This type of syncope is difficult to treat since it commonly involves both a vasodepressor and cardioinhibitory response, and typically requires removal of the irritative focus. We report a case of a 52-year-old male who presented from home with syncope. He endorsed a 5-week history of progressively worsened positional headaches and dramatic 40-pound weight loss with night sweats over 6 months. In the emergency department, his heart rate was noted to drop into the 20s with associated hypotension 60/31 mm Hg. Heart rate and blood pressure increased with intravenous atropine. Physical examination revealed a large ulcerative lesion in the left tonsillar area. After biopsy of the lesion, a diagnosis of stage IV squamous cell carcinoma of the neck was made; computed tomography angiogram and positron emission tomography/computed tomography confirmed involvement in the posterior tongue extending to the left palatine tonsil in addition to the left jugular chain. The patient was started on cisplatin and radiation therapy, but continued to have episodes of syncope associated with bradycardia and hypotension. After a failed trial of benztropine, the patient was started on sertraline and midodrine with resolution of syncope. This could be a potential treatment option in those with compressive mixed syncope who are not candidates for surgery or chemotherapy or are awaiting definitive treatment.
Do Elevated Inflammatory Markers Associate With Infection in Revision Shoulder Arthroplasty?
Authors: Chalmers Peter N , Sumner Shelby , Romeo Anthony A , Tashjian Robert Z
Published: January 2018

Background

Serologic erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) measurements, which have been successfully utilized in the lower extremity, are thought to lack adequate sensitivity in the diagnosis of infection after shoulder arthroplasty. The purpose of this study is to determine the diagnostic performance of preoperative white blood cell (WBC) count, ESR, and CRP in the diagnosis of infection in the setting of revision shoulder arthroplasty with the gold standard of infection being defined as a later diagnosis of infection.

Patients and methods

A national insurance database between the years of 2007 and 2015 (PearlDiver, Warsaw, IN) was queried for those patients who underwent revision shoulder arthroplasty using a combination of procedural (common procedural terminology codes 23472 and 23474) and diagnostic codes (International Classification of Diseases [ICD]-9 code 81.97 and equivalent ICD-10 codes). This database contains demographics, laboratory data, and complication data to allow identification of patients with an infection within 1 year postoperatively.

Results

The database contained 1392 patients who met criteria. Among these, the best diagnostic performance was with a combined test which was positive if CRP, ESR, or WBC was positive with a sensitivity of 7% to 42%, a specificity of 92%, a positive predictive value of 8% to 45%, a negative predictive value of 91%, and an accuracy of 84% to 85%. On multivariate analyses, predictors included an abnormal ESR (odds ratio 2.4, P = .05) and male gender (3.8, <.001).

Conclusions

Those patients with an abnormal preoperative ESR have significantly increased odds of a subsequent infection following revision shoulder arthroplasty. ESR, CRP, and WBC in combination are specific but insensitive. Level of Evidence: Diagnostic, Level III
A phase 1 study of ibrutinib in combination with R-ICE in patients with relapsed or primary refractory DLBCL
Authors: Sauter Craig S. , Matasar Matthew J. , Schoder Heiko , Devlin Sean M. , Drullinsky Pamela , Gerecitano John , Kumar Anita , Noy Ariela , Palomba Maria L. , Portlock Carol S. , Straus David J. , Zelenetz Andrew D. , McCall Susan J. , Miller Shoshana T. , Courtien Amanda I. , Younes Anas , Moskowitz Craig H.
Published: January 2018

Key Points

Ibrutinib plus R-ICE was safe, tolerable, and was not prohibitive to mobilizing hematopoietic stem cells for autologous transplantation. A favorable early signal in all evaluable rel/ref non-GC DLBCL achieving a complete metabolic remission was observed.
Routine versus on demand removal of the syndesmotic screw; a protocol for an international randomised controlled trial (RODEO-trial)
Authors: Dingemans S. A. , Birnie M. F. N. , Sanders F. R. K. , van den Bekerom M. P. J. , Backes M. , van Beeck E. , Bloemers F. W. , van Dijkman B. , Flikweert E. , Haverkamp D. , Holtslag H. R. , Hoogendoorn J. M. , Joosse P. , Parkkinen M. , Roukema G. , Sosef N. , Twigt B. A. , van Veen R. N. , van der Veen A. H. , Vermeulen J. , Winkelhagen J. , van der Zwaard B. C. , van Dieren S. , Goslings J. C. , Schepers T.
Published: January 2018

Background

Syndesmotic injuries are common and their incidence is rising. In case of surgical fixation of the syndesmosis a metal syndesmotic screw is used most often. It is however unclear whether this screw needs to be removed routinely after the syndesmosis has healed. Traditionally the screw is removed after six to 12 weeks as it is thought to hamper ankle functional and to be a source of pain. Some studies however suggest this is only the case in a minority of patients. We therefore aim to investigate the effect of retaining the syndesmotic screw on functional outcome.

Design

This is a pragmatic international multicentre randomised controlled trial in patients with an acute syndesmotic injury for which a metallic syndesmotic screw was placed. Patients will be randomised to either routine removal of the syndesmotic screw or removal on demand. Primary outcome is functional recovery at 12 months measured with the Olerud-Molander Score. Secondary outcomes are quality of life, pain and costs. In total 194 patients will be needed to demonstrate non-inferiority between the two interventions at 80% power and a significance level of 0.025 including 15% loss to follow-up.

Discussion

If removal on demand of the syndesmotic screw is non-inferior to routine removal in terms of functional outcome, this will offer a strong argument to adopt this as standard practice of care. This means that patients will not have to undergo a secondary procedure, leading to less complications and subsequent lower costs.

Trial registration

This study was registered at the Netherlands Trial Register (NTR5965), Clinicaltrials.gov (NCT02896998) on July 15th 2016.
Factors associated with timing of umbilical cord clamping in tertiary hospital of Nepal
Authors: Nelin Viktoria , KC Ashish , Andersson Ola , Rana Nisha , Målqvist Mats
Published: January 2018

Objective

Delayed umbilical cord clamping (DCC) (≥ 60 s) is recognized to improve iron status and neurodevelopment compared to early umbilical cord clamping. The aim of this study is to identify current umbilical cord clamping practice and factors determining the timing of clamping in a low-resource setting where prevalence of anemia in infants is high.

Results

A cross-sectional study design including 128 observations of clinical practice in a tertiary-level maternity hospital in Kathmandu, Nepal. Overall 48% of infants received DCC. The mean and median cord clamping times were 61 ± 33 and 57 (38–79) s, respectively. Univariate analysis showed that infants born during the night shift were five times more likely to receive DCC (OR 5.6, 95% CI 1.4–38.0). Additionally, infants born after an obstetric complication were 2.5 times more likely to receive DCC (OR 2.5, 95% CI 1.2–5.3), and babies requiring ventilation had a 65% lower likelihood of receiving DCC (OR 0.35, 95% CI 0.13–0.88). Despite the existence of standard protocols for cord clamping and its proven benefit, the lack of uniformity in the timing of cord clamping reveals poor translation of clinical guidelines into clinical practice.

Clinical trial registration ISRCTN97846009
The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking of neural stem cell-derived extracellular vesicles
Authors: Yoshimura Aya , Adachi Naoki , Matsuno Hitomi , Kawamata Masaki , Yoshioka Yusuke , Kikuchi Hisae , Odaka Haruki , Numakawa Tadahiro , Kunugi Hiroshi , Ochiya Takahiro , Tamai Yoshitaka
Published: January 2018

Extracellular vesicles (EVs) can modulate microenvironments by transferring biomolecules, including RNAs and proteins derived from releasing cells, to target cells. To understand the molecular mechanisms maintaining the neural stem cell (NSC) niche through EVs, a new transgenic (Tg) rat strain that can release human CD63-GFP-expressing EVs from the NSCs was established. Human CD63-GFP expression was controlled under the rat Sox2 promoter (Sox2/human CD63-GFP), and it was expressed in undifferentiated fetal brains. GFP signals were specifically observed in in vitro cultured NSCs obtained from embryonic brains of the Tg rats. We also demonstrated that embryonic NSC (eNSC)-derived EVs were labelled by human CD63-GFP. Furthermore, when we examined the transfer of EVs, eNSC-derived EVs were found to be incorporated into astrocytes and eNSCs, thus implying an EV-mediated communication between different cell types around NSCs. This new Sox2/human CD63-GFP Tg rat strain should provide resources to analyse the cell-to-cell communication via EVs in NSC microenvironments.
Strength Training Effects on Muscular Regeneration after ACL Reconstruction
Authors: FRIEDMANN-BETTE BIRGIT , PROFIT FRANCESCA , GWECHENBERGER THOMAS , WEIBERG NADINE , PARSTORFER MARIO , WEBER MARC-ANDRÉ , STREICH NIKOLAUS , BARIÉ ALEXANDER
Published: January 2018

Purpose

Protracted quadriceps muscle atrophy is observed after anterior cruciate ligament reconstruction (ACL-R). The aim of this study was to assess if quadriceps strength training with eccentric overload (CON/ECC+) is more efficient to induce muscle regeneration after ACL-R than conventional concentric/eccentric (CON/ECC) strength training.

Methods

Biopsies from the vastus lateralis muscle were obtained from 37 recreational athletes after 12 wk of regular rehabilitation after ACL-R and again after 12 wk with twice a week of either conventional CON/ECC (n = 16) or CON/ECC+ (n = 21) one-legged supervised leg-press training. Immunohistochemical analyses were used to determine satellite cell (SC) number (Pax7+); activated SC number (Pax7+/MyoD+); fibers expressing myosin heavy-chain (MHC) I and II, MHC neonatal, and fiber cross-sectional area. Magnetic resonance imaging was performed to measure quadriceps cross-sectional area and isokinetic testing for the measurement of quadriceps strength.

Results

CON/ECC+ induced a significantly (P = 0.002) greater increase in quadriceps cross-sectional area than did CON/ECC. There also was a significant increase in the fiber cross-sectional areas of all fiber types and in quadriceps strength, but without significant difference between training groups. Only CON/ECC+ training led to a significant (P < 0.05) increase in percent type I fibers. After training, the number of MHC I+/MHCneo+ fibers was significantly (P < 0.05) greater in the CON/ECC+ than after in the CON/ECC group. The proportion of hybrid fibers tended to decrease in both groups; percent type II fibers, SC number, and activated SC number remained unchanged.

Conclusions

CON/ECC+ leads to significantly greater muscle hypertrophy compared with CON/ECC, but without the hypothesized enhancing effect on SC activation. At the same time, CON/ECC+ induces a less favorable slower muscle phenotype for strong and fast movements.
The diagnostic accuracy of cross-sectional imaging for detecting acute scaphoid fractures in children: a systematic review
Authors: Offiah Amaka C , Burke Derek
Published: January 2018

Objective:

To determine the diagnostic accuracy of cross-sectional imaging for the diagnosis of acute scaphoid fractures in children.

Methods:

A systematic review of Medline, Embase and Cochrane databases between 1980 and July 2017 was independently performed by two observers. Criteria for study inclusion in a meta-analysis and assessment of the quality of such studies using the QADAS tool, were predetermined.

Results:

No studies were eligible for inclusion in a meta-analysis. Three studies (of low quality when assessed against the STARD guidelines for reporting of studies of diagnostic accuracy) assessed MRI (performed between Days 2 and 10 after acute injury) for the diagnosis of scaphoid fractures in a total of 119 children (age range 6 to 16 years). Study 1 (45 children) reported inter-observer reliability of radiographs and MRI of 0.53 and 0.95 respectively. Study 3 (18 children) reported a negative predictive value of MRI (even as early as Day 2), of 100%. No measure of diagnostic accuracy or observer reliability was reported in Study 2 (56 children). In all 3 studies, MRI identified more scaphoid fractures (and other carpal injuries) than radiographs. Study 3 showed that follow-up MRI between Days 38 and 45 added no new information compared to initial MRI.

Conclusion:

Based on a systematic review of the literature, there is currently no evidence on which to suggest an imaging protocol for suspected scaphoid fracture in children. Until such evidence is available, existing guidelines (which are based on findings from adult studies) should be followed.

Advances in knowledge:

(1) There is low quality evidence regarding the diagnostic accuracy of cross-sectional imaging for suspected scaphoid fractures in children and no evidence on which to propose an optimal imaging strategy. (2) Until such evidence is available, current guidelines (based predominantly on findings in adults and expert opinion) should be followed.
Computer-aided complete blood counts in dairy cattle of the Thessaloniki region: A clinical study
Authors: PANOUSIS (Ν. ΠΑΝΟΥΣΗΣ) N. , POLIZOPOULOU (Ζ. ΠΟΛΥΖΟΠΟΥΛΟΥ) Z. , FORTOMARIS (Π. ΦΟΡΤΟΜΑΡΗΣ) P. , PAPASTERIADIS (Α. ΠΑΠΑΣΤΕΡΙΑΔΗΣ) A. , KARATZIAS (Χ. ΚΑΡΑΤΖΙΑΣ) H.
Published: January 2018

This study reports the findings of complete blood counts (CBC), performed in 100 Friesian dairy cattle of various cattle farms in the Thessaloniki region. Farm selection was done with the criteria of proper management standards, such as housing, feeding schedules, vaccinations and deworming. According to their age and reproductive status, the animals were allocated in following five groups:• Group I: calves 0-3 months old.• Group II: calves 3-14 months old.• Group III: cows 14 months-3 years old.• Group IV: cows older than 3 years.• Group V: cows in the dry period.Analysis included the determination of hematocrit, hemoglobin, leucocyte and platelet counts with the aid of the veterinary hematology analyzer IDEXX QBC®, using the procedure specifically proposed for this animal species. Differential leucocyte counts were also done from blood smears prepared from each sample. Mean values of all the parameters evaluated were within the normal limits, reported in the literature.
Squamous cell carcinoma of the dog
Authors: KALDRYMIDOU (Ε. ΚΑΛΔΡΥΜΙΔΟΥ) E. , KANAKOUDIS (Γ. ΚΑΝΑΚΟΥΔΗΣ) G. , TOLIOU (Θ. ΤΟΛΙΟΥ) Th. , POUTAHIDIS (Θ. ΠΟΥΤΑΧΙΔΗΣ) Th. , KARAGIANNOPOULOU (Μ. ΚΑΡΑΓΙΑΝΝΟΠΟΥΛΟΥ) M.
Published: January 2018

Squamous cell carcinoma is the most common skin neoplasm with cellular evidence of malignancy. Neoplastic cells preserve characteristics of the stratum spinosum and infiltrate dermis. Squamous cell carcinomas classification is based on the degree of cell differentiation and tumor architecture and includes more than one categories. Immunohistochemistry is often applied in order to distinguish this carcinoma from other epithelial neoplasms. In the present study four squamous cell carcinomas of the dog were examined and classified. Three of them (2,3,4) presented low rates of differentiation so, immuhistochemical detection of cellular keratin was performed, in order to avoid confusion with other keratinizing epithelial neoplasms. Two out of the three above mentioned tumors (3,4) exhibited acantholysis and pseudogranular structures. Immunohistochemical detection of the carcinoembryonic antigen provided evidence to distinguish them from adenocarcinomas. Finally, in the fourth tumor (4) areas of diffuse cellular proliferation, without obvious keratinization, were observed. Many of these cells appeared elongated. In this case, the immunohistochemical detection of vimentin was performed in order to find out if these cells belonged to the connective tissue or to a spindle-cell squamous cell carcinoma.
Epizootiological. Study of sheep and goat abortion by Salmonella abortus ovis in Greece
Authors: GIANNATI-STEFANOU (Α. ΓΙΑΝΝΑΤΗ-ΣΤΕΦΑΝΟΥ) A. , BOURTZI-HATZOPOULOU (Ε. ΜΠΟΥΡΤΖΗ-ΧΑΤΖΟΠΟΥΛΟΥ) E. , SARRIS (Κ. ΣΑΡΡΗΣ) K. , XENOS (Γ. ΞΕΝΟΣ) G.
Published: January 2018

The epizootiological data concerning sheep and goat abortion cases were studied between 1980-1989. The abortion cases were investigated by cultural or serological exaninations. From the affected flocks, where abortions took place, 1.69% to 19.35% were considered as infected by Salmonella abortus ovis SAO after isolation of the organism. The serological examinations of flocks with abortions, revealed a positivity to SAO of 2.7% to 47%. The infected sheep flocks, that were ascertained by isolation of SAO prevailed against the corrensponding goat herds with an average of 11.25% to 6% respectively.
Atitude empática em estudantes de odontologia da Universidade Corporation Rafael Núñez na cidade de Cartagena
Authors: Fortich Mesa Natalia , Díaz-Narváez Víctor Patricio
Published: January 2018

Introdução: empatia refere-se a um aspecto da personalidade que desempenha um papel importante em relacionamentos interpessoais, facilitando relação dentista-paciente comunicação e competição, essa interação adequada tenderá a melhorar a qualidade do atendimento odontológico oferecido. O objetivo foi descrever o grau de atitude empática que os alunos têm de Graduação em Odontologia na cidade de Cartagena, Colômbia. Materiais e métodos: estudo exploratório e transversal, a amostra foi composta por 326 estudantes do 1o ao 5o ano. Foi utilizada escala de médico Empathy Jefferson versão «S» —eemj— (2), psicometricamente validados para medir a empatia. Para a análise dos resultados do teste foi aplicado Shapiro-Wilk normalidade médias foram comparadas usando um análise de variância (Anova) bifatorial Modelo III com a interação de primeira ordem. Com um nível de signi cância de p <0,05. Resultados: a con abilidade foi satisfatória (0,72). Os escores obtidos no JSPE variou de um mínimo de 54 e um máximo de 130 pontos para as mulheres e um mínimo de 55 e um máximo de 126 para os homens, as médias de empatia globais foi baixa 85,2 ± de, os resultados não foram signi cativos (p = 0,185) para o fator de nível académico e sexo (p = 0,25). Discussão: os resultados obtidos sobre os níveis de estudantes de medicina dentária orientação de empatia, em geral foram baixos. Em relação aos estudantes estudos na América do Norte, México e Chile. Os resultados obtidos neste estudo suportam a conclusão de que apesar de existirem diferenças estatisticamente signi cativas nos níveis de cursos de orientação de empatia examinados diminuiu orientação empatia de estudantes quando começam a prática clínica é observada. Estes resultados são consistentes com outros estudos onde ele pode ser visto que o nível de empatia apresenta uma tendência de queda como níveis aumentam carreira. Conclusões: embora não houvesse diferenças estatisticamente signi cativas na orientação empática entre os anos acadêmicos e de gênero; destaca-se que no último ano da corrida a pontuação aumentou; Os homens relataram níveis mais elevados de orientação empática em valores absolutos do que as mulheres; o nível mais alto de orientação empática foi detectado no grupo do terceiro ano.
Relationships between Eco-Leadership and Problem-Solving Styles of Gifted and Talented Youth
Authors: Friedel Curtis R. , Cletzer D. Adam , Bush Sarah A. , Barber J. Danielle
Published: January 2018

Our understanding of leadership has undergone a significant shift in the early part of the 21st century. An emerging perspective, dubbed Eco-Leadership, suggests leadership is a collective process involving both leaders and followers co-creating leadership. Because our beliefs and attitudes toward leadership affect how we lead, it becomes crucial to better understand the views youth have towards leadership, as they develop into our future leaders, to improve curricula and instruction. In this study, no relationship was found between youth attitudes and beliefs towards systemic and hierarchical thinking with respect to their preferred problem-solving style. These findings indicate youth may adaptively or innovatively associate leadership equally through systemic and hierarchical thinking. Further, neither being more adaptive nor more innovative implies one to be better at leading.
Moving from Competing to Complementary: UnderstandingtheInfluenceofPersonalNarrativeswhen Designing Leadership Studies Curriculum
Authors: GuramatunhuCooper NyashaM. , Lyons Linda M.
Published: January 2018

Leadership Studies education is a highly personal endeavor shaped by the personal experiences and philosophies of leadership educators. However, when course design collaboration opportunities are presented, teaching approaches and curriculum prioritization may be at odds because of distinct personal narratives. This article frames disagreement over course design as an unexpected yet useful tool for facilitating individual and collective examination of leadership educators’ narratives and how they inform teaching and curriculum priorities. Drawing from standpoint theory and positionality, this work emphasizes that questions about how and what to teach in a leadership course are influenced by life experiences of leadership educators.
Leadership as a Way of Being: A Way Forward for a News Industry in Chaotic Transition
Authors: Herndon Keith , McCline Richard
Published: January 2018

Hesselbein developed the concept: “leadership is a matter of how to be and not how to do.” Joseph later provided instructional content based on the concept and helped operationalize it for consumption by practicing leaders. This paper leverages their work in illustrating how leadership-as-a-way-of-being (LWB) can be a teaching model for emerging millennial leaders in a dynamic news media undergoing a chaotic transition. It provides a way to rethink newsroom organizational structures that no longer accommodate the needs of this generation. We focus on the “being” element of leadership as it speaks directly to a new introspective view of leadership that values transparency and is necessary for innovation over mere efficiency.
Developing Leadership Through “Serviceship”: Leveraging the Intersection Between Service-Learning and Professional Internship
Authors: Hastings Lindsay J. , Wall Milan , Mantonya Kurt
Published: January 2018

Considering the role of higher education in preparing the next generation of leaders for social change, leadership education is challenged to consider how best to prepare young adults for socially responsible leadership. Service-learning and professional internships, separately, have been identified as vehicles for preparing young adults for leadership roles. The purpose of this Application Brief is to describe a hybrid of service-learning and professional internships, called “Serviceship,” which employs undergraduate students as interns for a community rather than a company. Now in its fifth year at a Midwestern, four-year land-grant institution, the “Serviceship” program has placed 21 interns in 11 rural communities. Utilizing an asset-based community development framework, undergraduate students are matched with rural communities whose local leaders have self-identified a community development project.
How Can Service-Learning Prepare Students for the Workforce? Exploring the Potential of Positive Psychological Capital
Authors: McElravy L. J. , Matkin Gina , Hastings Lindsay J.
Published: January 2018

Although service-learning increases several important development and learning outcomes in college students (Yorio & Ye, 2012), it is not clear whether service-learning is better preparing these students for their future careers (Gray, Ondaatje, Fricker, & Geschwind, 2000). To better understand the influence of service-learning on student development, an exploration of a leadership service-learning course and an important workplace attribute, Positive Psychological Capital, are theoretically explored.
Taking a proactive approach to mild to moderate chronic oedema: a case study
Authors: Jehu Diane , Jenkins Linda , Morgan Karen , Thomas Melanie J
Published: January 2018

This case study demonstrates the benefits of early intervention and a proactive approach for a patient with chronic oedema living in the community. These benefited the patient and also supported value-based healthcare in the NHS. The patient's health and wellbeing significantly improved with an assessment of his chronic oedema and a management plan consisting of skincare, an exercise and movement programme and the introduction of a class 1 British standard compression garment.
More rigorous investigating needed to improve maternity safety
Authors: Quaile Alistair
Published: January 2018

Health Secretary Jeremy Hunt has announced new plans to investigate stillbirths and life-changing injuries at birth. Alistair Quaile reports progress made on the Safer Maternity Care action plan
How to create a portfolio
Authors: Fowler John
Published: January 2018

John Fowler explores some of issues involved in developing an account of your dental nursing experiences to date
Classroom management
Authors: Hart Richard
Published: January 2018

My effective classroom management initiative – Richard Hart offers three steps towards effective classroom management
Recruitment in 2018
Authors: Howells Paul
Published: January 2018

What teachers want – at a time when teacher vacancies are rising, schools need to adopt a candidate-centric approach to recruiting, argues Paul Howells
A produção de Materiais Didáticos críticos para o ensino de língua espanhola na EAD
Authors: Brandão Thaisa Alves
Published: January 2018

Este artigo tem o objetivo de apresentar uma reflexão não prescritiva a respeito produção de materiais didáticos críticos de língua espanhola LE no âmbito da Educação a Distância na contemporaneidade. Entendendo que “crítico” em língua estrangeira e em educação a distância é um conceito com características específicas, sobretudo na contemporaneidade, pelas características particulares de ensino e aprendizagem de língua estrangeira e do funcionamento da educação a distância.Por isso, serão discutidos os movimentos de uma sociedade impactada pela web 2.0 e como este fato influenciou no modo como as pessoas passaram a se relacionar com a tecnologia. Do mesmo modo, se refletirá como a educação a distância se apropriou desses usos tecnológicos e como conhecimento, aprendizagem e aprendizes tiveram suas posições alteradas em função disto a partir de um modelo pedagógico com características mais adequadas.Serão apresentados também os avanços da Linguística Aplicada e suas contribuições na produção de materiais didáticos críticos de língua espanhola, uma vez que as pesquisas neste campo do saber influenciam diretamente na produção de materiais didáticos que sejam plurais, dialoguem com as demandas de uma sociedade pós-colonizada de identidades múltiplas e com demandas urgentes. Entende-se então, que esses materiais didáticos devem ser reflexo da sociedade e que traga uma proposta emancipadora.Palavras Chave: Materiais didáticos críticos; Ensino e aprendizagem de língua espanhola; Educação a distância
Um livro didático de inglês e a representação de pessoas negras: desenhando uma abordagem de ensino-aprendizagem crítica
Authors: Moraes Bezerra Isabel Cristina Rangel , Nascimento Ana Beatriz Cardoso do , Ferreira Wellerson Da Silva
Published: January 2018

Nesse artigo, trazemos uma contribuição para a área que pesquisa a representação de pessoas negras em livros didáticos ao analisarmos um livro didático utilizado para o ensino de língua inglesa e propomos uma abordagem crítica para o ensino desse idioma. Trata-se de um recorte de pesquisa que se funda nos princípios da Prática Exploratória (MILLER, 2010, 2013) e que trata da formação inicial e continuada do professor de inglês. Esse movimento de olhar com mais cuidado alguns livros didáticos de inglês surgiu como demanda de dois professores em formação inicial, bolsistas de iniciação científica da pesquisa em questão. A arquitetura teórica desse artigo articula alguns estudos que fazem um resgate histórico da representação do negro em livros didáticos de algumas disciplinas escolares (RATTS; RODRIGUES; VILELA; CIRQUEIRA, 2006/2007; ROSEMBERG, BAZILLI, SILVA, 2003) e de língua inglesa, em particular, (FERREIRA; CAMARGO, 2013; FERREIRA, 2014). Trazemos contribuições dos campos da construção de identidade (MOITA LOPES, 2003) do letramento critico (JANKS, 2012) e do letramento visual (BAMFORD, 2009).
Proposta de atividade interdisciplinar para o estudo das línguas Portuguesa e Inglesa: uma experiência mediada pela pesquisa no Mestrado Profissional para Professoras
Authors: Silva Wagner Rodrigues , Moura Andréia Francisca , Rodrigues Aline Barbosa , Melo Lívia Chaves
Published: January 2018

Neste artigo, apresentamos o resultado de uma investigação desenvolvida com professoras matriculadas em um mestrado profissional para educadores e responsáveis pelo ensino de Língua Portuguesa, em escolas públicas brasileiras de ensino básico. Analisamos como as referidas profissionais compreendem os processos de alfabetização e de letramento, além de lidarem com essas noções teóricas no próprio local de trabalho. Analisamos ainda uma diretriz curricular em fase de aprovação pelo governo brasileiro, a qual regulamentará os conteúdos disciplinares e habilidades a serem trabalhados em cada etapa do ensino básico. Ao final do artigo, compartilhamos uma atividade pedagógica de análise linguística, considerando a Língua Portuguesa e a Língua Inglesa como disciplinas catalisadoras de conteúdos e saberes diversos. A atividade se configura como uma resposta aos desafios identificados nos dizeres das professoras e da diretriz curricular focalizada.
TWO MORE SOCIAL WASP SPECIES (VESPIDAE, POLISTINAE) COLLECT MULLERIAN BODIES FROM CECROPIA TREES (URTICACEAE)
Authors: Felizardo Sherlem Patrícia de S. , Borges R. C. , Santos J. N. A. , Silveira Orlando Tobias
Published: January 2018

The interactive behaviors of two species of social wasps, Protopolybia chartergoides (Gribodo) and Charterginus fulvus Fox with Cecropia obtusifolia (Cecropiaceae) are described. The use of Cecropia Müllerian bodies by the two wasps is also described, as well as the distribution of this trait in Protopolybia and Charterginus.