bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationships between Bone Turnover Markers and Factors Associated with Metabolic Syndrome in Prepubertal Girls and Boys
Authors: Bilinski Wojciech J. , Stefanska Anna , Szternel Lukasz , Bergmann Katarzyna , Siodmiak Joanna , Krintus Magdalena , Paradowski Przemyslaw T. , Sypniewska Grazyna
Published: March 2022

The associations between individual components of metabolic syndrome (MetS) and bone health in children are complex, and data on this topic are sparse and inconsistent. We assessed the relationship between bone turnover markers and markers of the processes underlying MetS (insulin resistance and inflammation) in a group of presumably healthy children aged 9–11 years: 89 (51 girls, 38 boys) presenting without any features of MetS and 26 (10 girls, 16 boys) with central obesity and two features of MetS. Concentrations of glucose, triglycerides (TG), HDL cholesterol (HDL-C), C-reactive protein (CRP), HbA1c, total 25-hydroxyvitamin D (25(OH)D), intact-P1NP (N-terminal propeptide of type I procollagen), CTX-1 (C-terminal telopeptide of type I collagen) were assayed and insulin resistance was assessed (HOMA-IR). BMI centile, waist circumference (WC) and blood pressure were measured. The presence of MetS in girls resulted in significantly lower concentrations of CTX-1 and a trend to lower CTX-1 in boys. The concentrations of bone formation marker i-P1NP were not affected. Among the features associated with MetS, HOMA-IR appeared as the best positive predictor of MetS in girls, whereas CRP was the best positive predictor in boys. A significant influence of HOMA-IR on the decrease in CTX-1 in girls was independent of BMI centile and WC, and the OR of having CTX-1 below the median was 2.8-fold higher/1SD increased in HOMA-IR (p = 0.003). A weak relationship between CTX-1 and CRP was demonstrated in girls (r = −0.233; p = 0.070). Although TG, as a MetS component, was the best significant predictor of MetS in both sexes, there were no correlations between bone markers and TG. We suggest that dyslipidemia is not associated with the levels of bone markers in prepubertal children whereas CRP is weakly related to bone resorption in girls. In prepubertal girls, insulin resistance exerts a dominant negative impact on bone resorption, independent of BMI centile and waist circumference.
Association between Alcohol Intake and Arterial Stiffness in Healthy Adults: A Systematic Review
Authors: Del Giorno Rosaria , Maddalena Ania , Bassetti Stefano , Gabutti Luca
Published: March 2022

Background: Arterial stiffness as assessed by Pulse Wave Velocity (PWV) represents an independent predictor of cardiovascular disease. Several dietary compounds and lifestyle factors could influence arterial stiffness. The debate on the significance of the correlation between alcohol consumption and arterial stiffness is still open, given that the relationship is complex and potentially affected by several factors such as alcohol type, consumption levels, gender and age differences. Objective: This systematic literature review aims to examine the evidence supporting an association between alcohol use and PWV, in electronic databases including PubMed/MEDLINE and the Cochrane Library, from January 2010 to November 2020. Screening and full-text reviews were performed by three investigators and data extraction by two. Considering the significant heterogeneity of data only a qualitative analysis (systematic review) was performed. Results: A total of 13 studies met the inclusion criteria. Alcohol consumption was independently associated with arterial stiffness in a J-shaped way in most of the studies included. A benefit of alcohol consumption on arterial stiffness was found in four experimental studies, whilst an unfavorable increasing linear association was found in four others. Associations were confirmed with both oscillometric and tonometric PWV assessment methods. In some studies, a gender and age correlation was found with a more pronounced association in older males. In all studies elevated levels of alcohol consumption were associated with a worsening of arterial stiffness. Conclusions: Despite the variable findings across studies, the current review provides preliminary evidence that light-to-moderate alcohol consumption is associated with arterial stiffness values lower than expected, and evidence that high doses accelerate arterial ageing. These findings could be useful for clinicians who provide recommendations for patients at cardiovascular (CV) risk. Nevertheless, given the heterogeneity of study designs, interventions, measurement methods and statistical evaluations, the protective role of moderate alcohol consumption on arterial stiffness is likely but not certain, warranting additional trials and evidence.
High Compliance to Mediterranean Diet Associates with Lower Platelet Activation and Liver Collagen Deposition in Patients with Nonalcoholic Fatty Liver Disease
Authors: Baratta Francesco , Cammisotto Vittoria , Tozzi Giulia , Coronati Mattia , Bartimoccia Simona , Castellani Valentina , Nocella Cristina , D’Amico Alessandra , Angelico Francesco , Carnevale Roberto , Pignatelli Pasquale , Del Ben Maria
Published: March 2022

The Mediterranean diet (Med-Diet) is considered the most effective dietary patterns to obtain weight loss in NAFLD patients. Previous evidence suggested that Med-Diet adherence could reduce cardiovascular risk and have a beneficial effect on NAFLD severity. Aim of the study was to investigate the relationship between Med-Diet adherence, platelet activation (PA), and liver collagen deposition. The study was performed in 655 consecutive NAFLD outpatients from the PLINIO study, a prospective observational cohort study aimed to identify non-conventional predictors of liver fibrosis progression in NAFLD. PA was measured by the serum thromboxane B2 (TxB2), and liver collagen deposition by N-terminal propeptide of type III collagen (Pro-C3). Adherence to the Med-diet was investigated by a short nine-item validated dietary questionnaire. Patients with high Med-Diet adherence were older and had less metabolic syndrome and lower serum triglycerides, GGT, TxB2, and Pro-C3. At multivariate regression analyses, in the linear model, the Med-Diet score negatively correlated with both TxB2 (Beta = −0.106; p = 0.009) and Pro-C3 (Beta = −0.121; p = 0.002) and in the logistic model high adherence inversely correlated with higher TxB2 tertiles (II tertile: OR = 0.576, p = 0.044; III tertile: OR = 0.556, p = 0.026) and Pro-C3 tertile (III tertile: OR = 0.488, p = 0.013). Low consumption of red meat inversely correlated with higher TxB2 tertile (II tertile: OR = 0.448, p < 0.001, III tertile: OR = 0.567, p = 0.004). In conclusion, NAFLD patients with high adherence to the Med-Diet show lower PA and liver collagen deposition, suggesting a protective role of the Med-Diet against NAFLD progression and cardiovascular risk. In addition, the correlation between TxB2 and Pro-C3 suggests a link between NAFLD severity and cardiovascular risk.
Multiple Effects of Resveratrol on Osteosarcoma Cell Lines
Authors: De Luca Angela , Bellavia Daniele , Raimondi Lavinia , Carina Valeria , Costa Viviana , Fini Milena , Giavaresi Gianluca
Published: March 2022

Osteosarcoma (OS) is the most common primary bone sarcoma affecting the life of pediatric patients. The clinical treatment faces numerous difficulties, including the adverse effects of chemotherapies, chemoresistance, and recurrences. In this study, the effects of resveratrol (RSV), a natural polyphenol, on OS cell lines were investigated to evaluate its action as an adjuvant therapy to the current chemotherapy regimens. RSV exhibited multiple tumor-suppressing activities on OS cell lines, inducing a series of critical events. We found (1) a cell growth inhibition due to an increase in cell distress, which was, in part, due to the involvement of the AKT and caspase-3 pathways, (2) an increase in cellular differentiation due to major gene expression levels of the osteoblastic differentiation genes, (3) an inhibition of IL-6 secretion due to an epigenetic effect on the IL-6 promoter, and (4) an inhibition of OS cells migration related to the decrease in IL-8 secretion levels due to an epigenetic effect on its promoter. Finally, the cotreatment of RSV with doxorubicin and cisplatin increased their cytotoxic effect on OS cells. Although further investigations are mandatory, it seems RSV might be a promising therapeutic adjuvant agent for OS cell treatment, exerting an antitumor effect when combined with chemotherapy.
Efficacy of Adaptogens in Patients with Long COVID-19: A Randomized, Quadruple-Blind, Placebo-Controlled Trial
Authors: Karosanidze Irina , Kiladze Ushangi , Kirtadze Nino , Giorgadze Mikhail , Amashukeli Nana , Parulava Nino , Iluridze Neli , Kikabidze Nana , Gudavadze Nana , Gelashvili Lali , Koberidze Vazha , Gigashvili Eka , Jajanidze Natela , Latsabidze Naira , Mamageishvili Nato , Shengelia Ramaz , Hovhannisyan Areg , Panossian Alexander
Published: March 2022

Currently, no effective treatment of comorbid complications or COVID-19 long-haulers during convalescence is known. This randomized, quadruple-blind, placebo-controlled trial aimed to assess the efficacy of adaptogens on the recovery of patients with Long COVID symptoms. One hundred patients with confirmed positive SARS-CoV-2 test, discharged from COVID Hotel isolation, Intensive Care Unit (ICU), or Online Clinics, and who experienced at least three of nine Long COVID symptoms (fatigue, headache, respiratory insufficiency, cognitive performance, mood disorders, loss of smell, taste, and hair, sweatiness, cough, pain in joints, muscles, and chest) in the 30 days before randomization were included in the study of the efficacy of Chisan®/ADAPT-232 (a fixed combination of adaptogens Rhodiola, Eleutherococcus, and Schisandra) supplementation for two weeks. Chisan® decreased the duration of fatigue and pain for one and two days, respectively, in 50% of patients. The number of patients with lack of fatigue and pain symptoms was significantly less in the Chisan® treatment group than in the placebo group on Days 9 (39% vs. 57%, pain relief, p = 0.0019) and 11 (28% vs. 43%, relief of fatigue, * p = 0.0157). Significant relief of severity of all Long COVID symptoms over the time of treatment and the follow-up period was observed in both groups of patients, notably decreasing the level of anxiety and depression from mild and moderate to normal, as well as increasing cognitive performance in patients in the d2 test for attention and increasing their physical activity and workout (daily walk time). However, the significant difference between placebo and Chisan® treatment was observed only with a workout (daily walk time) and relieving respiratory insufficiency (cough). A clinical assessment of blood markers of the inflammatory response (C-reactive protein) and blood coagulation (D-dimer) did not reveal any significant difference over time between treatment groups except significantly lower IL-6 in the Chisan® treatment group. Furthermore, a significant difference between the placebo and Chisan® treatment was observed for creatinine: Chisan® significantly decreased blood creatinine compared to the placebo, suggesting prevention of renal failure progression in Long COVID. In this study, we, for the first time, demonstrate that adaptogens can increase physical performance in Long COVID and reduce the duration of fatigue and chronic pain. It also suggests that Chisan®/ADAPT-232 might be useful for preventing the progression of renal failure associated with increasing creatinine.
Dihydroauroglaucin Isolated from the Mediterranean Sponge Grantia compressa Endophyte Marine Fungus Eurotium chevalieri Inhibits Migration of Human Neuroblastoma Cells
Authors: Vasarri Marzia , Vitale Giovanni Andrea , Varese Giovanna Cristina , Barletta Emanuela , D’Auria Maria Valeria , de Pascale Donatella , Degl’Innocenti Donatella
Published: March 2022

Cancer cell migration is a hallmark of the aggressiveness and progression of malignancies such as high-risk neuroblastoma. Given the lack of effective therapeutic solutions to counteract cancer progression, basic research aims to identify novel bioactive molecules with inhibitory potential on cancer cell migration. In this context, this work investigated the role of members of the salicylaldehyde secondary metabolite set from the sponge endophyte fungus Eurotium chevalieri MUT 2316 as potential inhibitors of human neuroblastoma SH-SY5Y cell migration. Since tetrahydroauroglaucin (TAG) and dihydroauroglaucin (DAG) were isolated in large amounts, both were evaluated for their anticancer properties towards SH-SY5Y cells. Both molecules were found to be non-cytotoxic by MTT assay and cytofluorimetric analysis. Moreover, DAG showed efficacy in inhibiting the highly migratory phenotype of SH-SY5Y cells by wound healing assay; whereas TAG, although structurally similar to DAG, showed no anti-migratory effect. Therefore, this work provides good reasons to conduct further in vitro and in vivo studies focusing on DAG as a potentially useful migrastatic natural marine molecule.
STOP Pain Project—Opioid Response in Pediatric Cancer Patients and Gene Polymorphisms of Cytokine Pathways
Authors: Crescioli Giada , Lombardi Niccolò , Vagnoli Laura , Bettiol Alessandra , Giunti Laura , Cetica Valentina , Coniglio Maria Luisa , Provenzano Aldesia , Giglio Sabrina , Bonaiuti Roberto , Mugelli Alessandro , Aricò Maurizio , Messeri Andrea , Vannacci Alfredo , Maggini Valentina
Published: March 2022

Moderate to severe cancer pain treatment in children is based on the use of weak and strong opioids. Pharmacogenetics play a central role in developing personalized pain therapies, as well as avoiding treatment failure and/or intolerable adverse drug reactions. This observational study aimed to investigate the association between IL-6, IL-8, and TNFα genetic single nucleotide polymorphisms (SNPs) and response to opioid therapy in a cohort of pediatric cancer patients. Pain intensity before treatment (PIt0) significantly differed according to IL-6 rs1800797 SNP, with a higher PI for A/G and G/G individuals (p = 0.017), who required a higher dose of opioids (p = 0.047). Moreover, compared to G/G subjects, heterozygous or homozygous individuals for the A allele of IL-6 rs1800797 SNP had a lower risk of having a PIt0 > 4. Dose24h and Dosetot were both higher in G/G individuals for TNFα rs1800629 (p = 0.010 and p = 0.031, respectively), while risk of having a PIt0 > 4 and a ∆VAS > 2 was higher for G/G subjects for IL-6 rs1800795 SNP compared to carriers of the C allele. No statistically significant association between genotypes and safety outcomes was found. Thus, IL-6 and TNFα SNPs could be potential markers of baseline pain intensity and opioid dose requirements in pediatric cancer patients.
Liposomal siRNA Formulations for the Treatment of Herpes Simplex Virus-1: In Vitro Characterization of Physicochemical Properties and Activity, and In Vivo Biodistribution and Toxicity Studies
Authors: Jbara-Agbaria Doaa , Blondzik Saskia , Burger-Kentischer Anke , Agbaria Majd , Nordling-David Mirjam M. , Giterman Anna , Aizik Gil , Rupp Steffen , Golomb Gershon
Published: March 2022

Herpes simplex virus-1 (HSV-1) is highly contagious, and there is a need for a therapeutic means to eradicate it. We have identified an siRNA (siHSV) that knocks down gene expression of the infected cell protein 0 (ICP0), which is important in the regulation of HSV infection. The selected siHSV was encapsulated in liposomes to overcome its poor stability, increase cell permeability, and prolonging siRNA circulation time. Several siRNAs against ICP0 have been designed and identified. We examined the role of various parameters, including formulation technique, lipids composition, and ratio. An optimal liposomal siHSV formulation (LipDOPE-siHSV) was characterized with desirable physiochemical properties, in terms of nano-size, low polydispersity index (PDI), neutral surface charge, high siHSV loading, spherical shape, high stability in physiologic conditions in vitro, and long-term shelf-life stability (>1 year, 4 °C). The liposomes exhibited profound internalization by human keratinocytes, no cytotoxicity in cell cultures, no detrimental effect on mice liver enzymes, and a gradual endo-lysosomal escape. Mice biodistribution studies in intact mice revealed accumulation, mainly in visceral organs but also in the trigeminal ganglion. The therapeutic potential of siHSV liposomes was demonstrated by significant antiviral activity both in the plaque reduction assay and in the 3D epidermis model, and the mechanism of action was validated by the reduction of ICP0 expression levels.
Multi-Attack Detection: General Defense Strategy Based on Neural Networks for CV-QKD
Authors: Du Hongwei , Huang Duan
Published: March 2022

The security of the continuous-variable quantum key distribution (CVQKD) system is subject to various attacks by hackers. The traditional detection method of parameter estimation requires professionals to judge known attacks individually, so the general detection model emerges to improve the universality of detection; however, current universal detection methods only consider the independent existence of attacks but ignore the possible coexistence of multiple attacks in reality. Here, we propose two multi-attack neural network detection models to handle the coexistence of multiple attacks. The models adopt two methods in multi-label learning: binary relevance (BR) and label power (LP) to deal with the coexistence of multiple attacks and can identify attacks in real-time by autonomously learning the features of known attacks in a deep neural network. Further, we improve the model to detect unknown attacks simultaneously. The experimental results show that the proposed scheme can achieve high-precision detection for most known and unknown attacks without reducing the key rate and maximum transmission distance.
Experimental Demonstration and Simulation of Bandwidth-Limited Underwater Wireless Optical Communication with MLSE
Authors: Zhang Jialiang , Gao Guanjun , Li Jingwen , Ma Ziqi , Guo Yonggang
Published: March 2022

Underwater wireless optical communication (UWOC) is able to provide large bandwidth, low latency, and high security. However, there still exist bandwidth limitations in UWOC systems, with a lack of effective compensation methods. In this paper, we systematically study the bandwidth limitation due to the transceiver and underwater channel through experiments and simulations, respectively. Experimental results show that by using the 7-tap maximum likelihood sequence estimation (MLSE) detection, the maximum bitrate of the simple rectangular shape on–off-keying (OOK) signaling is increased from 2.4 Gb/s to 4 Gb/s over 1 GHz transceiver bandwidth, compared to the conventional symbol-by-symbol detection. For the bandwidth limitation caused by the underwater channel, we simulate the temporal dispersion in the UWOC by adopting a Monte Carlo method with a Fournier–Forand phase function. With MLSE adopted at the receiver, the maximum available bitrate is improved from 0.4 to 0.8 Gb/s in 12 m of harbor water at the threshold of hard-decision forward-error-correction (HD-FEC, 3.8 × 10−3). Moreover, when the bitrate for 0.4 Gb/s 12 m and 0.8 Gb/s 10 m OOK transmission remains unchanged, the power budget can be reduced from 33.8 dBm to 30 dBm and from 27.8 dBm to 23.6 dBm, respectively. The results of both experiments and simulations indicate that MLSE has great potential for improving the performance of bandwidth-limited communication systems.
D–π–A–π–D Initiators Based on Benzophenone Conjugate Extension for Two-Photon Polymerization Additive Manufacturing
Authors: Li Shanggeng , Liu Xiaolin , Zhang Shuai , Zhou Yawen , Wan Xiangyu , Li Ning , Li Jing , Zhang Lin
Published: March 2022

A two-photon polymerization initiator is a kind of nonlinear optical material. With the demand for more efficient initiators in two-photon polymerization additive manufacturing, there are more and more related studies. In this paper, four conjugate-extended two-photon polymerization initiators with different alkane chain lengths were designed and synthesized, and single-photon, two-photon, and photodegradation experiments were carried out. Additive manufacturing experiments illustrated that the designed molecules can be used as two-photon initiators, and the writing speed can achieve 100,000 μm/s at a laser power of 25 mW. Through theoretical calculation and experimental comparison of the properties of molecules with different conjugation degrees, it was proven that a certain degree of conjugation extension can improve the initiation ability of molecules; however, this improvement cannot be extended infinitely. Solubility tests of different acrylates showed that molecules with different alkane chain lengths have varying solubility. Changing the molecular alkane chain length may be favorable to adapt to different monomers.
Biochemical and Elemental Composition of Pelagic Sargassum Biomass Harvested across the Caribbean
Authors: Tonon Thierry , Machado Carla Botelho , Webber Mona , Webber Deanna , Smith James , Pilsbury Amy , Cicéron Félix , Herrera-Rodriguez Leopoldo , Jimenez Eduardo Mora , Suarez Julio V. , Ahearn Michael , Gonzalez Frederick , Allen Michael J.
Published: March 2022

Massive and recurrent strandings of pelagic Sargassum biomass have become the new norm in the Caribbean and the Western Africa since 2011, and there is no sign of this abating. These Sargassum events have negative environmental, socioeconomic and health impacts in the affected countries. In the meantime, various processing techniques and applications have been suggested for valorisation of this biomass. However, variability in quantity, quality and location creates substantial uncertainty for the development of reliable and robust industrial processes. As part of ongoing efforts to better characterise seasonal and geographical variations in the biochemical and elemental composition of the pelagic Sargassum biomass across the Caribbean, we analysed samples from Mexico, Jamaica and the Dominican Republic harvested during summer 2020 and winter 2021. Different degrees of variation were observed in the contents of ash, metals and metalloids, vitamins, fatty acids, amino acids and biogenic amines, and monosaccharides. Our results indicate that biomass is of highly variable quality depending on season and location. In this context, we suggest that biorefinery approaches geared towards controlled metal removal and focused on the extraction and purification of amino acids, fatty acids and vitamins should be prioritised to assess the potential valorisation of pelagic Sargassum biomass into standardised and high-value outputs.
Salinity Modulates Juncus acutus L. Tolerance to Diesel Fuel Pollution
Authors: Pérez-Romero Jesús Alberto , Barcia-Piedras José-María , Redondo-Gómez Susana , Caçador Isabel , Duarte Bernardo , Mateos-Naranjo Enrique
Published: March 2022

Soil contamination with petroleum-derived substances such as diesel fuel has become a major environmental threat. Phytoremediation is one of the most studied ecofriendly low-cost solutions nowadays and halophytes species has been proved to have potential as bio-tools for this purpose. The extent to which salinity influences diesel tolerance in halophytes requires investigation. A greenhouse experiment was designed to assess the effect of NaCl supply (0 and 85 mM NaCl) on the growth and photosynthetic physiology of Juncus acutus plants exposed to 0, 1 and 2.5% diesel fuel. Relative growth rate, water content and chlorophyll a derived parameters were measured in plants exposed to the different NaCl and diesel fuel combinations. Our results indicated that NaCl supplementation worsened the effects of diesel toxicity on growth, as diesel fuel at 2.5% reduced relative growth rate by 25% in the absence of NaCl but 80% in plants treated with NaCl. Nevertheless, this species grown at 0 mM NaCl showed a high tolerance to diesel fuel soil presence in RGR but also in chlorophyll fluorescence parameters that did not significantly decrease at 1% diesel fuel concentration in absence of NaCl. Therefore, this study remarked on the importance of knowing the tolerance threshold to abiotic factors in order to determine the bioremediation capacity of a species for a specific soil or area. In addition, it showed that NaCl presence even in halophytes does not always have a positive effect on plant physiology and it depends on the pollutant nature.
The Hyperbranched Polyester Reinforced Unsaturated Polyester Resin
Authors: Feng Lifei , Li Ran , Yang Han , Chen Shanwei , Yang Wenbin
Published: March 2022

We report a method of reinforcing and toughening unsaturated polyester resin (UPR) with a kind of hyperbranched polyester (HBP-1). Polyethylene glycol with different molecular weight was used as the core molecule of the preparation reaction, and the reaction product of phthalic anhydride and glycerol was used as the branching unit. The esterification reaction of polycondensation occurred, and then the hydroxyl-terminated hyperbranched polyester was prepared. The reaction product of maleic anhydride and isooctanol was added to the prepared hydroxyl-terminated hyperbranched polyester for esterification reaction. Both ends of the hyperbranched polyester had unsaturated double bond to obtain the hyperbranched polyester (HBP-1). The effects of this treatment on the morphology, mechanical properties and thermal properties of the composites were studied in detail. The HBP-1 was investigated by Fourier Transform Infrared Spectroscopy (FT-IR). The HBP-1/UPR composites were investigated by Thermogravimetric Analysis (TGA), Dynamic Mechanical Analysis (DMA), mechanical properties analysis and Scanning Electron Microscope (SEM). The results showed that HBP-1 enhanced the thermostability and mechanical properties of UPR. However, DMA indicated that the addition of HBP-1 cannot effectively improve the thermodynamic properties of UPR due to the flexible chain in HBP-1 structure. The HBP-1 improves tensile strength, bending strength and impact strength compared to neat UPR.
Experimental Investigations on Bond Behavior between FRP Bars and Advanced Sustainable Concrete
Authors: Zhou Yingwu , Wu Guojian , Li Limiao , Guan Zhipei , Guo Menghuan , Yang Lei , Li Zongjun
Published: March 2022

In response to resource shortage and carbon dioxide emissions, an innovative type of sustainable concrete containing LC3, seawater, sea sand, and surface-treated recycled aggregates is proposed in this study to replace traditional concrete. To understand the bond properties between the sustainable concrete and CFRP bars, an investigation was conducted on the bond behavior between sand-coated CFRP bars and advanced sustainable concrete. Pull-out tests were carried out to reveal the failure mechanisms and performance of this bond behavior. The results showed that the slip increased monotonically along with the increase in confinement. The bond strength increased up to approximately 15 MPa, and the critical ratio of C/D was reached. The critical ratio approached 3.5 for the Portland cement groups, while the ratio was determined as approximately 4.5 when LC3 was introduced. When the proportion of LC3 reached 50%, there was a reduction in bond strength. A multisegmented modified bond–slip model was developed to describe the four-stage bond behavior. In terms of bond strength and slip, the proposed advanced concrete exhibited almost identical bond behavior to other types of concrete.
Thermal and Rheological Characterization of Recycled PET/Virgin HDPE Blend Compatibilized with PE-g-MA and an Epoxy Chain Extender
Authors: Santos Raquel M. , Costa Anna R. M. , Almeida Yêda M. B. , Carvalho Laura H. , Delgado João M. P. Q. , Lima Elisiane S. , Magalhães Hortência L. F. , Gomez Ricardo S. , Leite Boniek E. , Rolim Fagno D. , Figueiredo Maria J. , Lima Antonio G. B.
Published: March 2022

In this work, recycled poly(ethylene terephthalate) (PETR) was blended with virgin high-density polyethylene (HDPE) in an internal mixer in an attempt to obtain a material with improved properties. A compatibilizer (PE-g-MA) and a chain extender (Joncryl) were added to the PETR/HDPE blend and the rheological and thermal properties of the modified and unmodified blends as well as those of virgin PET with virgin HDPE (PETV/HDPE). All the blends were characterized by torque rheometry, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The data obtained indicate that the incorporation of either the chain extender or the compatibilizer agent led to increases in torque (and hence in viscosity) of the blend compared to that of the neat polymers. The joint incorporation of the chain extender and compatibilizer further increased the viscosity of the systems. Their effect on the crystallinity parameters of HDPE was minimal, but they reduced the crystallinity and crystallization temperature of virgin and recycled PET in the blends. The thermal stability of the PETR/HDPE blend was similar to that of the PETV/HDPE blend, and it was not affected by the incorporation of the chain extender and/or compatibilizer.
Research on Decision Making of Design for Coupling System Based on Complexity Composite
Authors: Zhang Peng , Chen Shaohan , Zhao Boyuan , Nie Zifeng
Published: March 2022

With the continuous improvement in user demand and the increasingly obvious complexity characteristics, such as strong coupling and nonlinearity of the system, it has become a new problem faced by the decision making of conceptual design. Decision-making methods in conceptual design such as traditional information axioms and the multi-criteria decision-making (MCDM) framework cannot provide a good solution for systems with strong coupling and nonlinearity. To fill these gaps, this paper proposes a decision-making method of design for a coupling system based on a complexity composite method (DMDCC). DMDCC is composed of a prediction model and a synthetic paradigm. In the early stages of decision making of design, design-centric complexity (DCC) theory is used to preliminarily sort the schemes. Then, driven by the twin data of existing products, the complexity of function units is obtained by using the prediction model. The complexity of different function units is composited by the composite paradigm to obtain the total function realization probability of the design scheme. A more accurate calculation of the total function realization probability of new products can assist designers to judge the scheme from the perspective of function and help to guide the decision making of the design of new systems’ development scientifically and reasonably. The engineering example of the bulk traditional Chinese medicine dispensing device is used to verify the scientific effectiveness of the research.
A Sustainable Advance Payment Scheme for Deteriorating Items with Preservation Technology
Authors: Roy Dipa , Hasan S. M. Mahmudul , Rashid Md Mamunur , Hezam Ibrahim M. , Al-Amin Md , Chandra Roy Tutul , Alrasheedi Adel Fahad , Mashud Abu Hashan Md
Published: March 2022

Profitably managing inventories is always a big challenge for retailers in the current context of transparent and competitive business. A general retailer always needs to handle both deteriorating and non-deteriorating products simultaneously to run a business. Deterioration of products sometimes impacts a retailer’s profits badly—a situation which can be alleviated by implementing proper preservation technology. In addition, to improve profits and minimize costs, a retailer always seeks some credit facilities (e.g., advance payment, trade credit facilities, etc.) from the supplier to continue the business smoothly with minimum investment. Advance payment is renowned for preventing the possibility of business orders being canceled and helping the retailer to minimize the risk of investing significant amounts at a single time. The foremost objective of this research is to analyze the facilities of advance payment and preservation technology investment and concurrent attempts to deal with shortages. This study shows that, given the presence of preservation technology, the result of case II is 68.06% higher than that of case I, whereas when preservation technology is absent, the result of case II is 71.93% higher than that of case I. The managerial insights of this analysis reveal that preservation technology attempts to prolong product life by preventing deterioration, which contributes to the retailer’s profitable business. On the other hand, in the case of an advance payment scheme, although the costs are relatively high, the study emphasizes the importance of the advance payment facility as it limits the risk of order cancellation and makes business more flexible for both supplier and retailer. The proposed model is solved by the classical optimization technique. Some theoretical derivations with numerical analysis support the model and provide some managerial insights for practitioners.
Recent Advances in Creating Biopreparations to Fight Oil Spills in Soil Ecosystems in Sharply Continental Climate of Republic of Kazakhstan
Authors: Akhmetov Lenar I. , Puntus Irina F. , Narmanova Roza A. , Appazov Nurbol O. , Funtikova Tatiana V. , Regepova Ainur A. , Filonov Andrey E.
Published: March 2022

The problem of eliminating petroleum pollution and its consequences is currently very relevant for Kazakhstan, which is among the ten largest oil-producing countries. The specifics of natural conditions—the sharply continental arid climate—necessitate the development and application of adequate technologies for the restoration of oil-contaminated territories and the Caspian seashore. The key factors (temperature, moisture, alkalinity, salinity, low mineral and organic matter content) affect the self-purification processes and microbiological status of oil-contaminated soils of Kazakhstan. The assessment of taxonomic diversity and characteristics of oil-degrading microorganisms isolated from samples of soils and reservoirs contaminated with hydrocarbons are given. The review of biopreparations and biotechnologies developed and used in Kazakhstan for cleaning environments from oil pollution is made, and their effectiveness is shown. The analysis of the current state of research in the field of biodegradation of hazardous pollutants and bioremediation of oil-contaminated areas allows us to identify promising areas of further work and approaches to the development and improvement of technologies for environmental protection.
Possibilities to Increase Assembly Line Productivity Using Different Management Approaches
Authors: Kádárová Jaroslava , Janeková Jaroslava , Suhányiová Alžbeta
Published: March 2022

A number of scientific methods are used to support productivity growth in companies, aimed at reducing waste, balancing assembly lines and supporting the introduction of automation into assembly processes. Their use in industrial practice is widespread, especially in large and medium-sized enterprises, and small businesses that use scientific methods to a limited extent. The aim of the research is to show the assembly process of throttle valves implemented in a small company, the effects of balancing the current assembly line and the effects of proposals of variant solutions on the automated assembly line and on the amount of hourly assembly production and costs per product. Within costs, two cost types are monitored: namely the hourly labor costs, and hourly machine costs. The sum of the hourly assembly line costs is determined by their sum. In the results section, the main sources of waste in the assembly process are identified, and eight proposals leading to the elimination of waste are processed. In the discussion, the individual proposals are evaluated in terms of the cost of one product, the hourly production of assembly and the tact times of assembly lines. The proposal that is evaluated as the best process is compared with the current state. The purpose of this article is to point out the advantages of the implementation of scientific methods in industrial practice, the achieved savings in the solved problem, and thus, to support those scientific methods in the management of assembly processes which are beginning to be used in greater extents by small businesses.
Study on Parameter Optimization of Diversion Wall in an Eight-Strand Tundish during Continuous Casting of Billet with High Casting Speed
Authors: Liu Zhenyu , Li Yang , Cheng Changgui , Lan Peng , Wu Weili
Published: March 2022

With the increasing demand for high-efficient continuous casting, parameter optimization during high-speed continuous casting is critical. To clarify the changes in flow characteristics in a multistrand tundish and the optimization principles for the diversion wall, a numerical investigation of an eight-strand tundish during continuous casting of billet was carried out in this paper. The simulation results were validated with the physical results of a 1:3 water model experiment. The results show that, for a tundish with the same flow control device, the average residence time and the maximum residence time difference of liquid steel in different strands are significantly reduced with higher casting speed. At different casting speeds, the effect of the hole diameter and deflection angle of diversion wall on the average residence time and the dead region proportion is very minor, while that on the maximum residence time difference of liquid steel in different strands is significant. For a given tundish, to improve the flow uniformity among multiple strands, parameter optimization of diversion wall should be optimized when the casting speed increases. When the casting speed is 4.4 m/min, the hole diameter of the diversion wall is 80 mm, and the deflection angle of the diversion wall is 74°, the flow field parameters of liquid steel in the eight-strand tundish are good, especially flow uniformity among multiple strands.
Market Opportunities of Water Treatments Powered by Solar Micro Gas Turbines: Chile and Ecuador Case Studies
Authors: Petit Blanca , Sánchez-Carceller Eva , Montes-Sánchez Jesús , González-Almenara Rafael , Sánchez David
Published: March 2022

Throughout the last decades the developments on desalination field have been focused on energy consumption and costs reduction. However, water recovery and brine disposal are becoming a matter of concern to desalination industry. In this work, a Zero Liquid Discharge (ZLD) unit coupled with a Solar Micro Gas Turbine (SMGT) system is presented to address, among others, the challenges of mining industry in remote areas, in particular, fossil fuel dependence, water availability and pollution derived from effluents disposal. As a way to assess the feasibility of the proposal, a techno-economic analysis of the application in two Southern American regions (Chile and Ecuador) of photovoltaic modules, wind turbines and Solar Micro Gas Turbines is performed. Afterwards, the main novel feature of the new system—i.e., the ZLD unit—is described and a sensitivity analysis on its functioning whilst coupled with the SMGT is carried out. The aim is to propose a preliminary design of the ZLD process. The selection of the optimal ratio between exhaust gases and brine mass flow rates is analyzed, as well as variation in inlet salinity and temperatures. Furthermore, the water which could be recovered from effluents, at the same time that the heat of exhaust gases from SMGT is harvested, is quantified. Lastly, according to the results obtained, a preliminary design of a 10 kWe rated power SMGT system, coupled to Reverse Osmosis (RO) and ZLD units, is proposed.
Pilot-Scale Protein Recovery from Cold-Pressed Rapeseed Press Cake: Influence of Solids Recirculation
Authors: Ahlström Cecilia , Thuvander Johan , Rayner Marilyn , Mayer Labba Inger-Cecilia , Sandberg Ann-Sofie , Östbring Karolina
Published: March 2022

The agricultural sector is responsible for about 30% of greenhouse gas emissions, and thus there is a need to develop new plant-based proteins with lower climate impact. Rapeseed press cake, a by-product from rapeseed oil production, contains 30% high-quality protein. The purpose of this study was to recover protein from cold-pressed rapeseed press cakes on a pilot scale using a decanter and investigate the effect of recirculation of the spent solids fraction on protein yield. Proteins were extracted under alkaline conditions (pH 10.5) followed by precipitation at pH 3.5. Recirculating the spent solids fraction once increased the accumulated protein yield from 70% to 83%. The efficiency of the recovery process was highest in the first and second cycles. The additional yield after the third and fourth cycles was only 2%. The amino acid composition showed high levels of essential amino acids and was not reduced throughout the recovery process. The glucosinolate and phytate content was reduced in the precipitate after one cycle, although additional process steps are needed to further reduce the phytate content and limit the negative effect on mineral uptake.
On-Farm Spatial Composition, Management Practices and Estimated Productivity of Urban Farms in the San Francisco Bay Area
Authors: Arnold Joshua Earl
Published: March 2022

Urban areas are the fastest growing land type worldwide. By 2060, it is expected that approximately 70% of the human population will live in cities. With increased urban population growth, food sovereignty and security issues have gained more attention, resulting in a drastic increase in urban food production activities including, urban farming and gardening. The extent to which urban farms function, their social, ecological and economic composition, and their overall impact on local food security has become an often overlooked, but important topic. From 2014 to 2017, we partnered with 29 urban farms in the San Francisco Bay Area for a broad-scale survey of urban farm characteristics. Findings reported in this research focused on local (on-farm) characteristics, including management practices, on-farm spatial composition, and estimated productivity. We implemented open-ended surveys for farm managers to better understand management practices, measured on-farm elements, including yields, crop biodiversity, weed composition and abundance, and measured spatial characteristics such as area of production, non-crop area, and proportion of infrastructure to better understand how urban farms were spatially configured. We found trends regarding spatial composition, including a large proportion of farm area dedicated to infrastructure and underutilized potential production space. All farms surveyed had adopted a breadth of agroecological management practices, including cover cropping, crop rotations, intercropping, and a range of soil conservation practices. Measured farms are incredibly productive, with estimated seasonal yields of 7.14 kg/square meter. Estimated yields were comparable with actual yields as measured at two participating farms.
A Myth for the Sixth Mass Extinction: Telling Noah’s Story during a Climate Crisis
Authors: Menning Nancy
Published: March 2022

Myths are open storylines that invite elaboration and modification. The flood narrative of Genesis 6–9, for example, has been readily employed to motivate endangered species protection and to reflect on the rising seas and mass extinctions associated with climate change. The distinctive features of any retelling of the Noah’s ark story reflect the needs of historically situated and culturally embedded audiences. This paper focuses on four versions of Noah’s story: in Genesis, in the Qur’an, at Ark Encounter theme park, and in Darren Aronofsky’s film Noah. Analysis identifies the narrative choices that align each telling with its cultural context and draws out insights for adapting the story for the contemporary climate crisis. A conclusion addresses issues of race and racial injustice in traditional interpretations of Noah’s story, and highlights approaches to redress those inequities in new imaginings of the flood narrative.
“Cutting Up a Chicken with a Cow-Cleaver”—Confucianism as a Religion in Japan’s Courts of Law
Authors: Larsson Ernils
Published: March 2022

This paper explores the Naha Confucius Temple case, resolved by the Supreme Court in February 2021, in light of postwar decisions on Articles 20 and 89 of the Japanese constitution. Religion is a contested category in Japanese legislation, appearing both in the constitution and in laws regulating the freedoms and restrictions of legally registered religious organizations. While the organization behind the Confucius Temple in Naha was registered as a general corporate juridical person, the majority opinion sided with the plaintiffs’ argument that the free lease granted to the temple by the municipality of Naha constituted a violence of the ban on public sponsorship of religious institutions and activities. In order to reach their decision, the Supreme Court and the lower courts not only had to decide on whether Confucianism was a religion or not, but also on whether the organization behind the temple—a group dedicated to the history and memory of the Chinese immigrant community in Naha—should in fact be considered a religious organization. The outcome of the case is a good example of religion-making in courts of law, with a central institution of power employing notions of sui generis religion to regulate and define civil actors.
Special Issue “Risks: Feature Papers 2021”
Authors: Steffensen Mogens
Published: March 2022

The 2021 Feature Papers Special Issue is a list of high-quality research output that shows the width and the breadth of the journal Risks [...]
Special-Rate Life Annuities: Analysis of Portfolio Risk Profiles
Authors: Pitacco Ermanno , Tabakova Daniela Y.
Published: March 2022

Special-rate life annuities are life annuity products whose single premium is based on a mortality assumption driven (at least to some extent) by the health status of the applicant. The health status is ascertained via an appropriate underwriting step (which explains the alternative expression “underwritten life annuities”). Better annuity rates are then applied in presence of poor health conditions. The worse the health conditions, the smaller the modal age at death (as well as the expected lifetime), but the higher the variance of the lifetime distribution. The latter aspect is due to significant data scarcity as well as to the mix of possible pathologies leading to each specific rating class. A higher degree of (partially unobservable) heterogeneity inside each sub-portfolio of special-rate annuities follows, and this results in a higher variability of the total portfolio payout. The present research aims at analyzing the impact of extending the life annuity portfolio by selling special-rate life annuities. Numerical evaluations have been performed by adopting a deterministic approach as well as a stochastic one, according to diverse assumptions concerning both lifetime distributions and portfolio structure and size. Our achievements witness the possibility of extending the annuity business without taking huge amounts of risk. Hence, the risk management objective “enhancing the company market share” can be pursued without significant worsening of the annuity portfolio risk profile.