bluuebunny/crossref_metadata_2025 huggingface dataset:
The Mechanisms of Current Platinum Anticancer Drug Resistance in the Glioma
Authors: Lu Enzhou , Gareev Ilgiz , Yuan Chao , Liang Yanchao , Sun Jingxian , Chen Xin , Beylerli Ozal , Sufianov Albert , Zhao Shiguang , Yang Guang
Published: June 2022

Gliomas are the most common and malignant primary tumors of the central nervous system (CNS). Glioblastomas are the most malignant and aggressive form of primary brain tumors and account for the majority of brain tumor-related deaths. The current standard treatment for gliomas is surgical resection supplemented by postoperative chemotherapy. Platinum drugs are a class of chemotherapeutic drugs that affect the cell cycle, and the main site of action is the DNA of cells, which are common chemotherapeutic drugs in clinical practice. Chemotherapy with platinum drugs such as cisplatin, carboplatin, oxaliplatin, or a combination thereof is used to treat a variety of tumors. However, the results of gliomas chemotherapy are unsatisfactory, and resistance to platinum drugs is one of the important reasons. The resistance of gliomas to platinum drugs is the result of a combination of influencing factors. Decreased intracellular drug concentration, enhanced function of cell processing active products, enhanced repair ability of cellular DNA damage and blockage of related apoptosis pathways play an important role in it. It’s known that the pathogenic properties of glioma cells and the response of glioma towards platinum-based drugs are strongly influenced by non-coding RNAs, particularly, by microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). miRNAs and lncRNAs control drug sensitivity and the development of tumor resistance towards platinum drugs. This mini-review summarizes the resistance mechanisms of gliomas to platinum drugs, as well as molecules and therapies that can improve the sensitivity of gliomas to platinum drugs.
South African (501Y.V2) and the United Kingdom (B.1.1.7) SARS-CoV-2
Spike (S) Protein Variants Demonstrate a Higher Binding Affinity to
ACE2
Authors: Mohammad Anwar , Al-Mulla Fahd , Abubaker Jehad
Published: June 2022

Introduction:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), affects the lower respiratory tract by binding to angiotensin-converting enzyme 2 (ACE2) via its S-protein. Recent emerging SARS-CoV-2 variants from the United Kingdom (B.1.1.7) and South Africa (501Y.V2) are spreading worldwide at an alarming rate. The new variants have manifested amino acid substitution K417N, E484K and N501Y on the RBD domain that binds to ACE2. As such, these mutations may influence the binding of the S-protein to ACE2 and affect viral entry into the host cell.

Methods:

In this study, we modelled the amino acids substitutions on the S-protein and utilised HADDOCK server to assess the S-protein RBD domain binding with ACE2. Additionally, we calculated the binding affinity of ACE2 to S-protein WT, B.1.1.7 and 501Y.V2 variants using Molecular Mechanics-Generalized Born Surface Area (MM/GBSA).

Results:

We demonstrate that the S-protein of both variants possesses higher binding affinity to ACE2 than WT, with the South African 501Y.V2 is a more infective strain than the B.1.1.7 that originated in the United Kingdom.

Conclusion:

The South African 501Y.V2 variant presents three amino acid substitutions that changed the H-bonding network resulting in a higher affinity to ACE2, indicating that the 501Y.V2 strain is more infective than the B.1.1.7 strain.
Lymphatic Regulation in Tissue Repair and Regeneration: Recent
Advances and Future Perspective
Authors: Bei Yihua , Liu Jianyun , Xiao Junjie
Published: June 2022

Lymphatic vasculature plays essential role in interstitial tissue uptake, immune cell transport
and dietary lipid absorption. Increasing evidence has demonstrated the contribution of lymphangiogenesis
to tissue repair and regeneration, which is associated with multiple factors such as improved tissue homeostasis,
inflammation resolution, and immunomodulation effects. Meanwhile, lymphangiogenesis has the
potential to regulate cell growth and proliferation through paracrine effects. Lymphatic vessels can also
be important components of the stem cell niche and participate in regulating stem cell quiescency or activity.
In perspective, the functions and mechanisms of lymphatic vessels in tissue repair and regeneration
deserve further investigation. Novel strategies to stimulate lymphangiogenesis by using pharmacological,
genetic, and lymphatic tissue engineering will be prospective to promote tissue repair and regeneration.
Recent Advances of Artificial Intelligence Tools in Attention-Deficit Hyperactivity
Disorder (ADHD)
Authors: Kaur Ginpreet , Walvekar Shreya , Thawkar Baban , Chintamaneni Meena
Published: June 2022

Attention deficit hyperactive disorder or ADHD is a common disorder among children, and
if not identified early, it may affect the child’s later life. Pharmacotherapy in ADHD has been linked to
the emergence of other emotional disorders. Children who get pharmacological treatment are more
likely to continue taking these medications until adulthood, increasing their risk of acquiring other
psychological problems. As a result, the majority of ADHD patients are eventually prescribed numerous
medicines to manage emotional difficulties as well. Thus, AI tools are seen to be a boon for
ADHD patients and clinicians. There have been emerging approaches in using artificial intelligence
tools to diagnose and treat ADHD in recent years. Different algorithms and medical devices are used
for greater accuracy and precision. The various neural networks detect complex signals in the human
brain and analyze them. As it is a neurodevelopmental disorder, AI gives the best tools for proper diagnosis
and treatment. Virtual and physical branches of AI are a great help to the patient. This review
article focuses on the use of various AI models and tools that employ ADHD symptoms, MRI scans,
and EEG signals, using electroencephalogram sensors to monitor brain activity, to help physicians better
manage this prevalent neurodevelopmental disorder.
Rumo(res) a um Teatro não teatral. Grotowski e os anos 70
Authors: Piva Bruno Leal
Published: June 2022

Grotowski estabelece uma investigação artística com integrantes de diversas culturas, carregados por seus dramas sociais, rituais e comportamentos socioculturais. O Parateatro é abordado prioritariamente no contexto histórico-cultural entre 1970 e 1975, promovido também pelo movimento de contracultura e ruptura da dicotomia ator/espectador, para uma participação ativa de todos envolvidos. Cultura, história, arte e teatralidade são alicerces para esta discussão. Estabelece-se contato com pesquisas acerca de aspectos comportamentais socioculturais da performance, lidando com o trabalho transcultural do Teatro das Fontes entre 1976 e 1982. Esses períodos despontam caminhos para um teatro não teatral grotowskiano e sugerem a arte como veículo de transformação do mundo individual e coletivo. Erika Fischer-Lichte, Richard Schechner e Victor Turner formam parte do núcleo de suporte teórico.
FAMILIA OLACACEAE
Authors:   Instituto de Ecología, A.C. Centro Regional del Bajío, Calderón de Rzedowski Graciela
Published: June 2022

Familia pantropical, de 27 géneros y cerca de 200 especies, de las cuales de nuestra zona de estudio se conocen dos: Schoepfia y Ximenia. El primero tiene unas 23 especies de distribución pantropical; 19 de ellas en América. Algunas se han encontrado como hemiparásitas de raíces. Por otro lado, Ximenia tiene unas ocho especies de regiones tropicales y subtropicales, en su mayoría americanas, tres de ellas en México; solamente Ximenia parviflora se conoce de la región de esta Flora. X. americana L., de distribución pantropical, es conocida por sus frutos comestibles, sus semillas oleaginosas, así como por su madera perfumada de buena calidad.
FAMILIA BETULACEAE
Authors:   Instituto de Ecología A.C. Centro Regional del Bajío, Carranza González Eleazar , Madrigal Sánchez Xavier ,   Facultad de Biología Universidad Michoacana de San Nicolás de Hidalgo
Published: June 2022

Familia con seis géneros y alrededor de 100 especies, distribuidas principalmente en las regiones templadas septentrionales y en zonas montañosas tropicales. Algunas son de interés económico: de Betula se obtiene madera aserrada y aceites aromatizantes; las semillas producidas por varias especies de Corylus son comestibles (“avellanas”); en algunos lugares se elabora carbón de la madera de Alnus y Betula, mientras que la de Carpinus y Ostrya es apreciada por su dureza; la corteza, hojas o frutos de ciertas especies de Ostrya y Alnus, se utilizan como medicinales. En la zona de estudio se encuentran tres géneros.
FAMILIA LAURACEAE
Authors:   Missouri Botanical Garden, Van der Werff Henk , Lorea Francisco ,   Instituto de Ecología, A.C.
Published: June 2022

Familia de aproximadamente 50 géneros y 2500 a 3000 especies, mayormente de distribución tropical y subtropical. Plantas de gran importancia comercial como el aguacate (Persea americana Mill.) y la canela (Cinnamomum verum Presl) pertenecen a las Lauraceae, la primera, de origen mesoamericano, se cultiva ampliamente en México y también localmente en la región de esta Flora. La diversidad y abundancia de especies de la familia en algunos bosques del país ha resultado en su reconocimiento como "Bosques de Lauráceas", de gran interés biológico por la diversidad total de plantas y animales que albergan. Entre los aspectos ecológicos importantes de algunos representantes de la familia, resalta su papel como productores principales del sustento alimenticio de varias aves.
An elementary expression in five variables relevant to many road accidents
Authors: Hutchinson Timothy Paul
Published: June 2022

This article suggests a model for many road accidents, namely, those in which a vehicle being driven forwards encounters an obstacle such as a pedestrian, a vehicle, or a tree. An equation for speed of impact is obtained from the model. (Speed of impact is very important in determining severity of injury.) The equation is an expression in five variables. As it is elementary, it will be of interest to educators in mathematics and other subjects, as well as to road safety specialists. Two of the five variables (speed of vehicle, and distance of the obstacle) are conditions existing at the initiation of the emergency; and three are approximately termed: range of the sensing system; reaction time; and deceleration; and are properties of the system of driver and vehicle. Thus the focus is on the moment the emergency is appreciated, a few seconds before impact. The model and equation may be relevant to some railway accidents, also. In addition, the article discusses how to push our understanding to a point some seconds earlier, in the hope of throwing light on accident causation.
References

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T. P. Hutchinson. Road Safety Theory. Published online. 2018. url: http://RoadSafetyTheory.com
T. P. Hutchinson. The theory of reduction of impact speeds. Traf. Eng. Control 56 (2015), pp. 177–180
D. N. Lee. A theory of visual control of braking based on information about time-to-collision. Perception 5 (1976), pp. 437–459. doi: 10.1068/p050437
D. F. Moore. Minimization of occupant injury by optimum front-end design. Society of Automotive Engineers Technical Report No. 700416 (1970). doi: 10.4271/700416
D. Stewart, C. J. Cudworth, and J. R. Lishman. Misperception of time-to-collision by drivers in pedestrian accidents. Perception 22 (1993), pp. 1227–1244. doi: 10.1068/p221227
K. Suzuki, H. Tanaka, Y. Miichi, and M. Aga. Collision-mitigation level of collision-avoidance braking system. Int. J. Vehicle Safety 7 (2014), pp. 1–16. doi: 10.1504/IJVS.2014.058238
J. Wooller. Road traffic accidents in Adelaide and Brisbane, Australia—Excerpts from a report in preparation. Proceedings, 4th Conference, Australian Road Research Board 4 (1968), pp. 976–994. url: http://155.212.5.248/Presto/content/Detail.aspx?ctID=MjE1ZTI4YzctZjc1YS00MzQ4LTkyY2UtMDJmNTgxYjg2ZDA5&rID=OTAx&qrs=RmFsc2U=&ph=VHJ1ZQ==&bckToL=VHJ1ZQ==&rrtc=VHJ1ZQ==
Loneliness Among African Migrants Living in Portugal
Authors:   Oporto University, Oporto, Portugal, Neto Félix , Pinto Maria da Conceição ,   Oporto University, Oporto, Portugal
Published: June 2022

This study analyzed the degree of loneliness, as well as acculturation and adaptation factors related to it among African migrants. The study sample consisted of 759 migrants (48.5% females) from four ethnocultural groups (Angolans, Cape Verdeans, Guineans, and Mozambicans) living in Portugal. Participants’ mean age was 37 years, and the mean length of sojourn in this country was 21 years. Participants completed self-reported questionnaires to evaluate social contacts, language proficiency, ethnic identity, perceived discrimination, psychological adaptation, sociocultural adaptation, and intercultural adaptation; moreover, loneliness level was evaluated using the ULS-6 scale. Most participants did not report high levels of loneliness. However, as expected, loneliness correlated negatively with social contacts, ethnic identity, and Portuguese language proficiency, whereas it correlated positively with perceived discrimination. The three adaptation factors negatively predicted loneliness beyond acculturation factors. This study also discussed the implications of this research for counselors.
Assessing acceptability of home blood monitoring for cancer patients who are receiving systemic anti-cancer therapy from a patient, caregiver, and clinician perspective: a qualitative study (Preprint)
Authors: Vercell Amy
Published: June 2022

BACKGROUND

Regular blood testing is an integral part of systemic anti-cancer therapy delivery. Blood tests are required before every administration of treatment to ensure a patient is well enough to receive it. Blood testing is burdensome for patients as they require either an extra visit within 48 hours of planned administration, or a significantly longer visit if done on the day of treatment. The additional time for appointments can have a significant impact upon the quality of life of someone who is living with cancer. In the UK the COVID-19 pandemic created an unprecedented disruption to the delivery of cancer care. Face to face hospital visits were reduced, resulting in a need to develop more innovative ways of working to minimise treatment interruptions. This led to a significant uptake of digital technologies, with new models of care rapidly deployed across the UK health service to meet these challenges.

OBJECTIVE

In this study we explore the acceptability of a point of care home blood monitoring device for people with cancer who are receiving systemic anti-cancer therapy, which is being developed in response to the increased need for remote care for patients with cancer.

METHODS

Qualitative focus groups and semi-structured interviews were conducted with patients (n=23), caregivers (n=6), and healthcare professionals (n=18) over a 19-month timeframe, from May 2019 to December 2020.
Data were analysed using framework analysis guided by the Unified Theory of Acceptance and Use of Technology model.

RESULTS

Analysis identified four overarching themes: 1) performance expectancy; 2) effort expectancy; 3) social influence; 4) facilitating conditions.

CONCLUSIONS

This study found that patients with cancer, caregivers, and healthcare professionals had positive perceptions of home blood monitoring. Whilst they are often considered synonymously, self-testing and self-management are not mutually exclusive, and this study illustrated some disparity in opinion regarding patient self-management. Home blood monitoring has the potential to provide patients with cancer with a convenient option for blood monitoring. It would minimise hospital attendances, decrease late treatment deferrals, and provide prompt recognition of cancer treatment toxicities, enhancing existing nurse-led protocols and clinical pathways. Home blood monitoring would create a long-term sustainable transformation for the delivery of cancer care, utilising digital health to act as a facilitator to address a pertinent issue regarding improving the efficiency of hospital resources and increasing the delivery of personalised patient care.

CLINICALTRIAL

REC Reference 18/EE/0343, IRAS project ID 234137
Correction: Durability of the Treatment Effects of an 8-Week Self-administered Home-Based Virtual Reality Program for Chronic Low Back Pain: 6-Month Follow-up Study of a Randomized Clinical Trial (Preprint)
Authors: Garcia Laura , Birckhead Brandon , Krishnamurthy Parthasarathy , Mackey Ian , Sackman Josh , Salmasi Vafi , Louis Robert , Castro Carina , Maddox Roselani , Maddox Todd , Darnall Beth D
Published: June 2022

UNSTRUCTURED

see manuscript
Digenic Alport Syndrome
Authors: Savige Judy , Renieri Alessandra , Ars Elisabet , Daga Sergio , Pinto Anna Maria , Rothe Hansjorg , Gale Daniel P. , Aksenova Marina , Cerkauskaite Agne , Bielska Olga , Lipska-Zietkiewicz Beata , Gibson Joel T.
Published: June 2022

Digenic Alport syndrome refers to the inheritance of pathogenic variants in COL4A5 plus COL4A3 or COL4A4 or in COL4A3 plus COL4A4. Where digenic Alport syndrome includes a pathogenic COL4A5 variant, the consequences depend on the sex of the affected individual, COL4A5 variant “severity,” and the nature of the COL4A3 or COL4A4 change. A man with a pathogenic COL4A5 variant has all his collagen IV α3α4α5-heterotrimers affected, and an additional COL4A3 or COL4A4 variant may not worsen disease. A woman with a pathogenic COL4A5 variant has on average 50% of her heterotrimers affected, which is increased to 75% with a further COL4A3 or COL4A4 variant and associated with a higher risk of proteinuria. In digenic Alport syndrome with pathogenic COL4A3 and COL4A4 variants, 75% of the heterotrimers are affected. The COL4A3 and COL4A4 genes occur head-to-head on chromosome 2, and inheritance is autosomal dominant when both variants affect the same chromosome (in cis) or recessive when they affect different chromosomes (in trans). This form of digenic disease results in increased proteinuria and a median age of kidney failure intermediate between autosomal dominant and autosomal recessive Alport syndrome. Previous guidelines have suggested that all pathogenic or likely pathogenic digenic variants should be identified and reported. Affected family members should be identified, treated, and discouraged from kidney donation. Inheritance within a family is easier to predict if the two variants are considered independently and if COL4A3 and COL4A4 variants are known to be inherited on the same or different chromosomes.
The Impact of Population Aging on FDI Inflow in China—An Empirical Analysis Based on Provincial Panel Data
Authors: Xinpeng Xu , Yunning Huang , Fuxia Gao , Yanting Ji
Published: June 2022

With the increasingly serious situation of population aging in China, the impact of population aging cannot be ignored. This study analyzes the effect of population aging on the attraction of FDI inflows in China through the construction of an empirical model. The results show that there is a significant “inverted-U” relationship between population aging and FDI inflows, and aging negatively affects foreign investment inflows after crossing the aging inflection point. Based on the findings, this study proposes policy recommendations based on the quantity and quality of the labor force, such as improving the policy of gradual delayed retirement, improving the level of human capital, and promoting the regional mobility of the labor force, to provide feasible research ideas to enhance the attractiveness of FDI in regions with different levels of aging.
ANALISIS RISIKO KESEHATAN MERKURI DALAM IKAN YANG DI PASARKAN DI KAWASAN TELUK KAO HALMAHERA UTARA
Authors: Makahenggang Kristin Natalia H , Rahardjo Djoko , Kisworo Kisworo
Published: June 2022

Penelitian analisa risiko kesehatan merkuri dalam ikan yang dipasarkan di kawasan teluk Kao bertujuan untuk mengetahui tingkat konsentrasi merkuri pada ikan, pola konsumsi dan laju asupan merkuri pada masyarakat konsumen serta identifikasi potensi risiko kesehatan. Penelitian dilakukan pada bulan Maret sampai dengan bulan Juli  tahun 2021 pada pasar-pasar tradisional dikawasan teluk Kao dan Kecamatan Tobelo Kabupaten Halmahera Utara, Maluku Utara. Sampel ikan yang diambil pada setiap pasar meliputi 6 spesies ikan yaitu : Katsuwonus pelamis, Nemipterus sp, Caranx ciliarus, Leiognathidae, Upeneus moluccensis Blkr dan Lates calcarifer. Penelitian dilakukan terdiri dari tiga tahapan yaitu pengambilan sampel di lapangan, preparasi sampel dan analisis merkuri dan analisis data. Analisis sampel menggunakan Mercury Analyzer. Terdapat 90 responden dan masing-masing kecamatan diambil 30 responden dengan menggunakan instrumen kuesioner dilakukan interview untuk mengetahui pola konsumsi ikan masyarakat di lokasi penelitian. Data dianalisis secara diskpritf kualitatif dan kuantitatif dengan korelasi-regresi untuk mengetahui hubungan antara faktor risk agent dengan risiko kesehatan. Hasil penelitian menunjukan bahwa semua spesies ikan yang diambil dari pasar tradisional Teluk Kao dan Kecamatan Tobelo telah terkontaminasi merkuri dengan kisaran 0,1-5,4 mg/kg (rata-rata sebesar 1,49 mg/kg) dan telah melebihi dari standar baku mutu yang ditetapkan sebesar 1,0 mg/kg. konsentrasi merkuri dipengaruhi oleh lokasi pengambilan sampel dan spesies ikan. Berdasarkan lokasi pengambilan sampel konsentrasi tertinggi di temukan pada kecamatan Tobelo sebesar 1,5 mg/kg dalam, kecamatan Malifut 1,4 mg/kg dan kecamatan Kao 1,0 mg/kg. Berdasarkan dengan spesies ikan kosentrasi merkuri tertinggi ditemukan dalam spesies Caranx ciliarus  5,4 mg/kg, Katsuwonus pelamis sebesar 4,7 mg/kg, spesies Katsuwonus pelamis sebesar 4,0 mg/kg dan terendah ditemukan pada spesies Katsuwonus pelamis sebesar 2,7 mg/kg. Terdapat perbedaan pola konsumsi ikan pada kedua kecamatan dimana pada kecamatan Kao memiliki pola konsumsi lebih tinggi sebesar 780 g dibandingkan kecamatan Malifut 541 g, dan laju asupan pada kecamatan Kao lebih besar 0,0042 g/hari dan kecamatan Malifut 0,0026 g/hari. Pola konsumso olan terkontaminasi merkuri oleh masyarakat teluk Kao tidak aman dan berpotensi menimbulkan risiko kesehatan dengan nilai risk quotient (RQ) semuanya diatas batas aman yang ditetapkan oleh WHO yaitu RQ 1
Does stock market performance have a long effect on economic growth: Evidence from MENA
Authors: Al Salamat Wasfi , Batayneh Khaled I.
Published: June 2022

Financial market has a close relationship with economic growth because increasing economic growth, representing the real gross domestic product (GDP), will enhance the efficiency and develop the stock market. On the other hand, the good performance of the stock market will affect economic growth positively. This paper aims to investigate the impact of stock market performance on the economic growth of a group of MENA countries during the time period 2000–2019. This study uses unbalanced panel data, unit root test, co-integration test, and autoregressive distributed lag (ARDL) model for data analysis (Kao, 1999; Pesaran, Shin, & Smith, 2001). The findings report that the stock market index, banking sector development, the ratio of foreign direct investment (FDI) to the GDP, and the consumer price index, as a proxy of inflation, have a significant positive long-run effect on the economic growth, while the ratio of broad money supply (M2) to the GDP has a significant negative long-run effect on the economic growth. The policymakers and government can based on the results of the study in developing and adopting policies to improve and enhance the efficiency of the stock market and attracting new investors inside and outside the country, which results in increasing the economic growth.
Covid-19 and (re)learning teaching: Never let a crisis go to waste
Authors: Wackenhut Arne F. , Gillette Maris Boyd
Published: June 2022

For universities around the world, the Covid-19 pandemic necessitated a rapid transition to online (remote, distance) education as authorities implemented measures to reduce infection rates. In Sweden, universities witnessed roughly 18 months of continuous online education, followed by a period of mixed and campus-based learning environments in the autumn of 2021, and a return to online education in early 2022 as infection rates increased. The Swedish government’s removal of restrictions and plans to remove Covid-19’s classification as a disease dangerous to society (samhällsfarlig sjukdom), however, suggest that universities will no longer be required to offer online instruction. In response to this shift, and in the spirit of Winston Churchill’s call to “never let a good crisis go to waste,” we investigate some changes in teaching and learning caused by the Covid transition. Findings in international studies about university adaptations to Covid and quantitative and qualitative data from our home institution indicate that distance education catalysed new technological engagements for students and teachers, while also reinforcing pedagogical and didactical developments discussed in the literature on teaching and learning in higher education. In other words, the Covid crisis encouraged instructors to (re)learn to teach – not merely by adopting new technologies, but also by implementing student-centred learning. To illustrate this claim, we examine key changes made by teachers in our department, which include pre-recorded mini-lectures, student-response technologies, and other practices loosely classifiable as interactive learning. These adaptations could facilitate teaching and learning on campus, should teachers choose to continue using them.
Closer and further away – emergency-remote teacher education, orientations and student-bodies
Authors: Åkesson Emilia , Just Edyta , Eriksson Barajas Katarina
Published: June 2022

This paper contributes knowledge on the effects of materiality and space on teaching and equal access to teacher education. Through an intersectional analysis, with a specific focus on orientations, bodies and materiality, we show how student-bodies orientate closer to or further from various parts of teacher education as an effect of the materiality of emergencyremote vs. on-campus education. We elaborate on three different student-body orientating processes that take place during teacher education. These are all related to the emergencyremote education implemented as a consequence of the COVID-19 pandemic. We call these processes ‘remote education as relief’, ‘the embodiedness of raising the hand on Zoom’ and ‘energy-draining pre-recorded lectures’. We show how the materiality of emergency-remote education orientates the participants situated within the bodily horizons of intersectional positions of being deaf, female, racialized as non-white and not having Swedish as a first language, both closer to and further away from various parts of their teacher education. The analysis is based on both individual and group interviews with twelve teacher students. The paper contributes insights to emergency-remote education, remote education and on-campus educating.
Historiography of the Establishment of the Tahfiz Plus Program at Universiti Teknologi MARA Based on the ADDIE Model
Authors: Lateh Najahudin , Osman Muhamad Rahimi , Din Ghafarullahhuddin
Published: June 2022

The establishment of the Plus Tahfiz program to strengthen the memorization of the Qur’an at Universiti Teknologi MARA (UiTM) in 2018 is the first of its kind in Malaysian higher education institutions. However, to date there has not been any scholarly writing related to the facts or history of the establishment of this program that has been compiled or written. Therefore, this paper was produced with the objective of recording the history of this program for the reference of various parties in the future. This study is qualitative in nature with a research framework based on the ADDIE Model developed by Molenda (2003) and modified into three phases, namely needs analysis, design and development. Data were collected from official university and external documentation as well as observations based on the author’s own experience who was directly involved in the proposed establishment. The data obtained were analyzed descriptively through content analysis methods with inductive and deductive processing. The results of this study obtained the historiography of the establishment of the Plus Tahfiz program in three phases according to the chronology of time for a year from October 2017 to September 2018 before being implemented throughout the campus at UiTM. This study is very beneficial to the information system of educational institutions, especially at UiTM as well as the main reference related to this program to all university administrators, tahfiz institutions, researchers and all lovers of Quranic knowledge.
Distance Learning: Rethinking learning design in higher education during the Covid-19 pandemic
Authors: Ferrari Luca , Fabbri Manuela
Published: June 2022

During the second semester of the 2019/2020 academic year, due to the regulatory restrictions arising from the Covid-19 pandemic, Bologna University, like many others, was compelled to stop delivering its face-to-face offering and to switch, in a very short time, to the creation of a technological architecture that would enable students to continue their education through teaching via Distance Learning. After illustrating the active teaching model adopted in two courses offered by the University of Bologna Department of Education Studies, this paper addresses future educators by focusing on the main findings from a semi-structured online questionnaire completed by 84 students. The first part of the paper considers a rethinking of educational planning at the time of Covid-19, while the second and final part analyses student perceptions (using the questionnaire’s open questions) of their Distance Learning experience in the initial phases of the pandemic scenario.
Tahapan-tahapan Laju Perkembangan Gerak dan Motorik pada Anak Usia Dini
Authors: Ahadin Ahadin
Published: June 2022

The development of motor movement is a change in motor behavior that occurs due to the process of maturity and the environment. Maturity is a change that occurs in the body over a period of time. What affects children's motor development are family, playmates, and the environment. Families, especially parents, are usually the ones who have the most influence on children's lives. Most of the children who want their parents to be happy with themselves and their efforts, Playmates, can influence the child to move stronger, and more freely. The environment in which children live in motor development, fine motor skills or gross motor skills is very direct and strong, especially if children are given formal education. We can interpret motor skills as a capacity possessed by individuals to be able to develop the ability of the abilities possessed by these individuals in an effort to be able to enhance or accelerate the mastery or proficiency of a skill. Children who have good motor skills, it will be easier to master motor skills, so that motor skills obtained through a process associated with the training process, or improvement can be through experience if changes in motor behavior are obtained through the learning process, then mastery of a child's physical motor movements will be permanent.
ЛЕКСИКО-СEМАНТИЧНИЙ АНАЛІЗ ІДІОМ З ЛЕКСИЧНИМ КОМПОНЕНТОМ НА ПОЗНАЧЕННЯ ПРИРОДНИХ ЯВИЩ В АНГЛІЙСЬКІЙ МОВІ
Authors: МИРОНЧУК Марина , БАЧУРІНА Людмила , АРЧАКОВА Єлизавета
Published: June 2022

Стаття присвячена вивченню лексико-семантичної структури ідіом з лексичним компонентом на позначення природних явищ в англійській мові. Звернення до хронотопу розвитку суспільства характеризує механізм еволюції фразеологізмів та допомагає визначити лінгвокультурологічну природу, яка, своєю чергою, зумовлює семантичні ознаки досліджуваної лексики та дає підстави для адекватного тлумачення лексичного значення ідіом. Метод компонентного аналізу, представлений у роботі, дав можливість виділити компоненти значеннєвої структури ідіом з лексичним компонентом на позначення природних явищ й прослідкувати, яким чином конотаційний компонент, що характеризує дію, трансформується в аксіологічний, який конституює підґрунтя образу, представленого в ідіомі. На основі виділених компонентів значеннєвої структури розроблено формулу тлумачення основної дії, яка відображає асоціативні зв’язки між реалією, представленою відповідними ідіомами, і номінантом. Емотивний компонент, безпосередньо пов’язаний з оцінкою ситуацій, представлених ідіомами, що мають у своєму складі лексеми на позначення природних явищ, аргументував розподіл їх на дві групи: група ідіом з позитивною оцінкою та група ідіом з негативною оцінкою. Першу групу утворюють ідіоми, що містять у свому складі лексеми на позначення небесних світил і явищ, що відбуваються в небі. Друга група представлена ідіомами, що містять у своєму складі лексеми на позначення опадів. Тож на матеріалі ідіом з лексичним компонентом на позначення природних явищ ще раз доведено, що характер образної підстави ідіом безпосередньо пов’язаний з оцінкою і емотивним компонентом. Зокрема, асоціативний образ, який конституюють ідіоми на позначення природних явищ, є результатом позитивного чи негативного їхнього впливу на життя людини.
A Simulation Analysis of Financing Public Housing Provision
Authors:   Korean Association for Housing Policy Studies, Park Joon , Pong In-Shik
Published: June 2022

This study aims to examine the feasibility of financing the provision of public housing with National Housing and Urban Fund in Korea, in order to increase the ratio of public rental housing to the level of 9% of the total housing stock which is the EU average. Total 27 scenarios from 1) three proportions of investment and loan of 20% and 40%, 20% and 60%, and 20% and 75%, 2) three rates of reduction of the fund to support to the projects other than public housing in the fund, and 3) three additional transfers of capital gain tax to the fund are used in simulation analyses. In the analyses to provide total 1.11 million housing units from 2022 to 2028, it was found that the fund can cover the total cost of the plan in the case of 20% and 40% proportion of investment and loan from the fund. In case of 20% and 60% proportion of investment and loan from the fund, the fund also can cover the total cost when the reduction rate is 5 or 10%. In other cases, a transfer of 2~34% of capital gain tax property pro rata to the fund makes the plan feasible. Despite various assumptions and operational scenarios this attempt can provide useful information about the financing of public housing that is the most critical issue in increasing them.
A Return Analysis on the Released Areas of the Redevelopment Projects in Seoul
Authors:   Korean Association for Housing Policy Studies, Song Young-Sun , Kim Ji-Yeon , Lee Chang-Moo
Published: June 2022

Newtown and Redevelopment projects, which were popular in the 2000s have caused various conflicts among different social and economic interest groups due to the prolonged recession in the real estate market. Accordingly, the Seoul government implemented an exit strategy for the maintenance project in 2012 to release the maintenance area and implemented a new paradigm-based urban regenration policy. However, the exit strategy for the maintenance project caused other problems; since 2013, housing prices in Seoul have been on the rise, which led to the recent market pressure on the resumption of the maintenace project.
The current study confirmed that the resumption of the maintenance project would be possible if an approximately 10% return was expected from the perspective of the union members in the maintenance project areas. A return rate analysis on the six areas that were released as a part of the exit strategy showed that the maintenance project for all areas could be resumed in the private sector, exceeding 10% of the preliminary required return.
The Agromyzidae (Diptera) of Colombia, including a new species attacking potato in Bolivia
Authors: SPENCER KENNETH A.
Published: June 2022

Keys to genera and species. of the Agromyzidae known in Colombia are provided and 15 new species are described: Melanagromyza spilanthis; Cerodontha sp. Cerodontha colombiensis, C. (C.) nigra; Liriomyza chiensis, L. colombie­lla, L. herrerai, L. hordei, L. madridensis, L. montserratensis, L. nigra, L. robustae; Phytoliriomyza colombiana, P. mede­Ilinensis, P. sabanae, P. similis. A new generic synonymy is established, with Geratomyza Spencer now formally synonymised with japanagromyza Sasakawa. Four pest species are recorded as new to Colombia: Melana­gromyza phaseolivora, Líromyza sativae, Phytomyza rufipes and Chromatomyia syngenesiae. A new species from Bolivia, Phytoliriomyza papae, feeding in potato stalks is described.
Contarinia gossypii Felt (Diptera: Cecidomyildae) NUEVA PLAGA DEL ALGODONERO
Authors: JIMÉNEZ-M. NORA C. , RAMÍREZ-N. BERNARDO
Published: June 2022

En cultivos de algodonero del Sinú, de 80 días de edad, se presentó durante la cosecha 83-84 una malformación de botones y "capullos" que al ocasionar la caída de las estructuras del tercio supe­rior pudo reducir la producción hasta en 700 Kg./ha, según estimativos pre­liminares. En muchos casos, la malfor­mación estuvo seguida por una pudri­ción bacterial producida por Pseudomonas sin tener aún claridad sobre la relación patógeno-insecto. La especie responsable de estos daños Contarinia gossypii (Diptera: Cecido­míidae) tiene larvas rosáceas, de 2 mm. de longitud cuando maduras, las cuales se alimentan internamente de pétalos y androceo, pudiéndose encontrar hasta 185 de ellas por botón de 6 mm. de diámetro. Las larvas abandonan las estructuras atacadas mediante un salto caracterís­tico para empupar en el suelo. Las pu­pas son obtectas, oscuras, de 1,2 mm de largo y protegidas por un cocon se­doso el cual se encuentra a poca pro­fundidad de la superficie del suelo. Los adultos son típicos cecidomyíidos de antenas y patas muy largas, recu­biertos de pilosidad oscura y densa que les da un aspecto de diminutas mosqui­tas grisáceas; miden aproximadamente de 1 a 2 mm. de longitud. Observaciones de laboratorio indican que la emer­gencia ocurre en las últimas horas de la tarde. Como enemigo natural se ha encontra­do un parásito de larvas de la familia Platygasteridae, cuyos puparios tam­bién se encuentran en el suelo. Fuera del algodonero no se ha encon­trado otra planta hospedante. Los re­gistros de C. gossípii en Cereté, Mon­tería, San Carlos, San Pelayo, Ciénaga de Oro y Lorica señalan su amplia dis­tribución en el Departamento de Cór­doba.
ESTUDIO COMPARATIVO DE CICLOS DE VIDA DE TRES ESPECIES DE DEFOLIADORES DEL Pinus patula
Authors: MADRIGAL-C. ALEJANDRO , WIESNER-R. LILIANA , ARANGO-E. MARÍA ISABEL
Published: June 2022

Este estudio comparó los ciclos de vida de Cargolia arana (Dognin), Bassania schereiteri Schaus y Melanolophia com­motaria (Maassen) (Lepidoptera: Geometridae), bajo dife:" rentes condiciones, ambientales. Las tres especies se criaron en la localidad de "Las Palmas" al Oriente de Medellín a 2120 msnm y 15,20C para confrontar con los datos obteni­dos en Caldas (Ant.) a 1800 msnm y 17°C, para las dos pri­meras, y con los obtenidos en Medellín a 1600 msnm y 19°C para la última. La duración total del ciclo mostró diferencias de 17,3, 17,5 y 25,2 días para C. arana, B. schreiteri y M. commotaria respectivamente, resultando más largo a menor temperatu­ra. Las diferencias mayores se presentaron durante el pe­ríodo larval. Toda la información obtenida en este estudio permite programar en forma más oportuna las labores de control en diferentes zonas donde estas especies se presen­ten en poblaciones que justifiquen tales medidas.
RESISTENCIA DE Phaseolus vulgaris L. SILVESTRE Y PROGENIES CON FRIJOL CULTIVADO AL GORGOJO COMUN Acanthoscelides obtectus (SAY) A NIVEL DE CAMPO Y LABORATORIO
Authors: POSSO-GÓMEZ CARMEN ELISA , FLOWER-VALOR JOSÉ , SCHOONHOVEN AART VAN
Published: June 2022

Bajo condiciones de campo y laborato­rio, se evaluó la resistencia de 26 ge­notipos de Phaseolus vulgaris L. al ataque de Acanthoscelides obtectus (Say) (Coleoptera: Bruchidae). En el ensayo de campo, a partir de la etapa de maduración de vainas, se realizaron infestaciones con adultos de A. obtec­tus. Se cosecharon 10 vainas/genotipo, las cuales se llevaron al laboratório para evaluarlas. También se seleccionaron vainas y semillas no atacadas por el brüchido para evaluar la resistencia en condiciones de laboratorio. Tanto en las infestaciones de campo como de laboratorio, se registraron di­ferencias significativas en cuanto a re­sistencia entre los genotipos. Las acce­siones de fríjol silvestre G12952, G12891 y G10019, utilizadas como padres resistentes, mostraron altos ni­veles de resistencia a A. obtectus en comparación con los testigos suscepti­bles V8030, V7920 y Diacol Calima. La resistencia y susceptibilidad de los genotipos seleccionados en F3 se com­portaron semejante en la generación F4 cosechada en el campo. Diferencias significativas se registraron también entre los genotipos infestados en el campo cuando se analizaron las perfo­raciones de oviposición en vainas y penetración de la larva en semillas.  Se registraron correlaciones significati­vas entre el número de adultos emergi­dos de semillas en el ensayo de labo­ratorio con los emergidos de vainas como consecuencia de la infestación en el campo. También en el ensayo de laboratorio, se encontraron correlacio­nes entre el número de adultos emer­gidos, peso seco de adultos y ciclo de vida en vainas con los mismos paráme­tros en semillas. Estos resultados indi­can que selecciones por resistencia a A. obtectus se pueden hacer tanto a nivel de vainas como de semillas.
BIOLOGIA, HÁBITOS Y POLIMORFISMO LARVAL DE Callopistria floridensis (Guenée) (LEPIDOPTERA:NOCTUIDAE), LARVA DE LOS HELECHOS
Authors: POSADA-F. FRANCISCO J. , SALDARRIAGA-V. ALFREDO
Published: June 2022

Desde 1977, la polilla de los helechos, Callopistria floriden­sis (Guenée) (Lepidóptera: Noctuidae) ha venido aumentan­do su importancia como plaga de los helechos ornamentales en Colombia. Hasta el presente se han encontrado 14 espe­cies de helechos como huéspedes. Registros de varios años muestran que la mayor población del insecto se presenta durante los períodos de verano y se encuentra de preferen­cia en las regiones con clima medio y cálido. Además de la importancia económica, el insecto también la tiene en el aspecto científico por su notorio y contrastante polimorfis­mo en el color de las larvas. El estudio del ciclo de vida, hábito; y poliformismo se realizó en Medellín a una tempe­ratura promedia de 21°C y humedad relativa de 75%. Este insecto presentó diferencias en el número de instares, reconocido como poliformismo. Se encontró que el 92,5% de las larvas.pasan por cinco instares, siendo el 54,050/o hembras y el 45,94% machos. El 7,5% restante desarro­llaron seis instares y todas fueron hembras. De acuerdo al grupo de instares la duración promedia del ciclo de vida de huevo a adulto fue variable. Sólo el período de incubación tuvo una duración constante de 5,71 días. La duración de la larva del grupo de machos de cinco insta­res fue de 36,63 días, incluyendo la prepupa (3,58 días), pupa 18,11 días para un total de huevo a adulto de 60,45 días. La duración de la larva del grupo de hembras de cinco instares fue de 35,95 días, incluyendo la prepupa (4,0 días) y pupa 16,15 días. El total de huevo a adulto para este gru­po fue de 57,81 días, tiempo más corto que la duración del grupo dé machos. El ciclo de vida del grupo de seis instares fue superior al del grupo de cinco instares con una duración de 64,04 días. Los adultos en cautiverio sobrevivieron en promedio 10,4 días, la relación de sexos fue de 1,35 ♀ : 1 ♂. El número promedio de huevos por hembra fue de 465,4. En el poliformismo de color se encontraron cinco tipos de larvas: 1) larva totalmente verde; 2) larva verde con una banda blanca arriba del espiráculo y una banda negra abajo del espiráculo; 3) idéntica a la anterior pero con manchas o puntos negros dorsales o subdorsales; 4) larva totalmente de color café oscuro a negro y 5) idéntica a la anterior pero con banda blanca arriba del espiráculo. Una misma larva puede o no variar de color en el transcurso de sus cinco o seis instares, pero el cambio de color sólo se efectúa a partir del tercer instar. El dimorfismo sexual de los adultos se reconoce porque los machos son de mayor tamaño, tienen las antenas filiformes pero con los veintiséis segmentos basales ensanchados, las patas con pelos largos y abundantes, teniendo las patas me­dias un mechó que cubre dos procesos espiníferos en la parte distal interior de la tibia. En constraste, la hembra posee antena totalmente filiforme, patas con pelos y el mechón presente pero más corto y escaso. El color café de las alas en las hembras es más oscuro que en los machos.
Fluctuación poblacional y dispersión del Picudo Negro del plátano Cosmopolites sordidus (Germar)
Authors: CÁRDENAS-M. REINALDO , ARANGO-B. LUIS G.
Published: June 2022

Con el fin de saber qué ocurre cuando una plantación de plátano atacada por Cos­mopolites sordidus Germar es qué influencia tiene la húme­dad del suelo y el exceso hí­drico en el suelo sobre el nú­mero de adultos capturados en dos tipos de cebos o tram­pas, se realizo este trabajo en la hacienda "Naranjal" Muni­cipio de Chinchiná (Caldas), en una plantación de 288 ma­tas de la variedad Dominico­hartón. Se utilizaron dos se­bos o trampas por cada 18 matas, lo cual dió un total de 32 cebos, de éstos, 16 fueron a base de cepa o rizoma y 16 a base de seudotallo. Estos cebos se colocaron tres meses después de sembrada la semi­lla y se renovaron cada cuatro semanas. Se hicieron lecturas semanales hasta un total de 53 observaciones. Los datos meteorológicos se registraron en una estación contigua al lote .donde se hizo el estudio. Para observar o medir la dis­persión se hizo una evalua­ción de la población existente antes de tumbar la platanera vieja y esta misma evaluación se hizo después de 15 meses de resembrada; además se capturaron adultos y se mar­caron con pintura luminiscen­te y se liberaron dentro de los cebos o en los bordes de la platanera. Los especimenes marcados y liberados en el borde de la platanera fueron recapturados en parte, des-pues de dos semanas, a 6-8 metros de distancia; los mar­cados y liberados en cebos fueron observados en mínima proporción en el sitio de la li­beración dos días después. En una plantación distante unos 20 m. del foco en estudio no se registro el insecto aún des­pués de 23 meses de registra­do el foco inicial. El insecto no es atraído por la descom­posición del material utilizado como cebo. Los cebos a base de rizoma son preferidos por los adultos de C. respecto a los cebos a base de seudotallo. Las precipitacio­nes acumuladas semanalmen­te, lo mismo que las precipi­taciones ocurridas durante las 24 horas anteriores a la lectu­ra de los cebos, no tienen re­lación con el número de adul­tos capturados. El exceso hí­drico, calculado en base a las lluvias y la evaporación de la semana anterior a la fecha de lectura, tampoco tuvo rela­ción con la población observada semanalmente. El picu­do negro del plátano se dis­persa a través de la semilla transportada por el hombre y es un insecto de hábitos sub­terraneos que no es afectado por las condiciones climáticas.