bluuebunny/crossref_metadata_2025 huggingface dataset:
General English Online Teaching Within Pandemic Outbreak: Between Need and Satisfaction
Authors: Wathoni Hamzani , Basri Hasan , Dwimaulani Astrid , Yunitasari Dukha
Published: July 2022

Since the COVID-19 pandemic entered Indonesia in 2019, a technological adjustment in learning has been massively implemented. Online teaching is the only logical method for the reason of limiting physical contact. Although the characteristics of Z-Generation learners are digital natives, live learning is still more welcomed. Therefore, this study aims to determine and carefully measure the satisfaction of new colleges students in the general English program at Universitas Hamzanwadi. The measures are three aspects (course content, instructor performance, and media use) and another aspect in teaching mode (online and offline). In addition, this research discusses why the new college students choose to participate in the general English program 2020/2021. This study utilized a quantitative-descriptive approach with the census method. The population was taken from all new students for the 2020/2021 period as many as six faculties totaling 1450, although only 1196 respondents ultimately responded. The primary data collection instruments were questionnaires through google forms, interviews, and documents such as teaching modules and media. The findings show 1196 respondents recorded via a google form telling that the bilingualism reasons were the majority choice (54.93%). The scholarships and student exchanges are the second paramount concern to this program (21.15%). Other positions such as translator or work, reasons are not significantly mentioned. Conclusion tells that new student satisfaction following the General English program (GE) is significantly more than 70 percent in three aspects of the assessment within the program.
An Analysis of Language Styles Used on Aaron Beverly Speech “An Unbelievable Story” in Toastmaster Public Speaking World Champion 2019
Authors: Dhila Anggi Satmaya , Sabarudin Syafrizal , Arasuli Arasuli
Published: July 2022

This research aims to find out types of using language style on speech by Aaron Beverly, titled “Unbelievable Story and the possible reason why the style use dominantly. The method used in this research was descriptive quantitative research. The data were analyzed with using Martin Joos Theory (1976) to find the types of the style. The data were 70 utterances from 1 speech script. The findings showed that there were 4 styles used in the speech, namely frozen style, formal style, casual style and intimate style. The language style of the speech tended to have casual style as the most dominant style. It was possible to the speaker making an interesting light speech with the dominant casual style. The speech might be presented in fun topic and chronology where it became informal situation which was more relaxed in using language. Finally, the researcher suggests to the student to be able implement the style in presentation class or in learning public speaking. Also, the next researcher who interest to conduct research in the same study to connecting research to the next new literary ideas such as in public speaking skills in business.
Students’ Perception on Individual Learning versus Cooperative Learning Using Numbered Heads Together (NHT) Method in English Classroom
Authors: Sonita Tiara , Febria Desty
Published: July 2022

In this era, teachers need to choose the proper method in teaching and vice versa; students’ participation in the classroom should be one of biggest concern for the teachers. With the right method, learning activities can be more effective to the students and will also improve their participation. This study intends to use Numbered Heads Together (NHT) as one of cooperative learning method to improve students’ participation in classroom. The methodology that being used is Classroom Action Research (CAR) and the research method is quantitative. The researchers will observe and implement the method by making two exercises in group, then give a self-assessment questionnaire to the students about their opinion to individual activities and group work activities. The results showed that NHT method is successfully improved students’ participation and activeness in the classroom with each of the students recorded to have significant improvement in their participation, while there are pros and cons from the self-assessment about the students’ preferences for each individual and group work activities. There are also advantages and disadvantages from NHT method itself. The disadvantage is no doubt making the student uncomfortable and don’t like to work in group. Further research is suggested to take action to the disadvantage of cooperative learning method.
Diagnóstico da leucemia linfoblástica aguda em crianças
Authors: Santos Jadielson da Silva , Sá Luiz Fernando Pereira de , Mata João Paulo de Oliveira , Teixeira Atílio da Silva , Crisanto Antonio Vinícius Sales de Moraes Souza , Amorim Gabriela Rodrigues , Pinheiro Flávia Piauilino , Guilhon Luana Amorim , Silva Ícaro Avelino , Sousa Gabriel Franco de , Pessoa Larissa dos Santos , Aguiar Maria Pereira de Queiroga , Aguiar Ulisses Nogueira de , Silva Amanda Miranda da , Gonçalves Walquer Vinicius Esteves
Published: July 2022

A leucemia linfóide ou linfoblástica aguda (LLA) infantil é decorrente do ataque às células linfóciticas do tipo B imaturos, resultante de danos genéticos adquiridos e não herdados, ocupando o primeiro lugar no ranking de incidência de doenças, segundo o instituto nacional do câncer (INCA). A melhoria nas técnicas de estudo proporciona agora a oportunidade de obter informações biológicas clinicamente relevantes que poderão explicar as respostas aparentemente anômalas ao tratamento. Este estudo teve como objetivo descrever as formas de diagnóstico úteis para a classificação e tratamento de Leucemia Linfoblástica Aguda em Crianças e apresentar as implicações das técnicas de citomorfologia, citogenética, imunofenotipagem e citoquímica no diagnóstico e prognóstico das leucemias. A revisão sistemática para elaboração deste consenso baseou-se preferencialmente em artigos indexados, publicados nos últimos dez anos fundamentados nos dados PubMed, Scielo, NCBI. Com os resultados foi possível perceber em relação ao hemograma, a contagem global de leucócitos na LLA em criançaspode estar diminuída, normal ou aumentada.  Já no mielograma, o diagnóstico da LLA em crianças é confirmado quando mais de 25% a 30% das células nucleadas são blastos. De acordo com as colorações citoquimicas, diagnostica-se LLA quando se obtém uma prova positiva para as técnicas de PAS. Portanto, o conhecimento a cerca das formas de diagnóstico e da classificação da LLA em crianças é de suma importância para um diagnóstico precoce e com isso promover um tratamento eficaz.
Risk factors for early neonatal sepsis: retrospective Cohort in the brazilian amazon
Authors: Gomes Adenilson Oliveira , Pereira Priscilla Perez da Silva , Godoy Ana Claudia Morais , Farias Jeanne Lúcia Gadelha , Freitas Pollyana Roberta , Ferreira Isabela Pimentel
Published: July 2022

Objective: to analyze risk factors for neonatal sepsis in a capital of the Brazilian Amazon region. Methods: Retrospective cohort of 411 mothers and their newborns assisted at the municipal maternity hospital from December 2019 to February 2020. Sociodemographic information, history of prenatal care, childbirth type and characteristics of the newborn were collected from the medical records of the binomial mother-child. To estimate the gross and adjusted Relative Risk and 95% confidence intervals, Poisson Robust Regression using Stata®, version 16.0 was used. Result: The incidence of sepsis was 75.42 per 1,000 live births. The risk factors for neonatal sepsis were previous infectious disease (RR: 2.40; 95% CI: 1.21; 4.76), APGAR score less than seven in the first minute (RR: 2.96; 95% CI:1.17; 7.47) and low birth weight (RR: 5.60 CI; 95%: 1.69; 18.50). Conclusion: The identification of predictors for the outcome and early monitoring of pregnant women in prenatal care are important actions to minimize the occurrence of neonatal sepsis. For future studies, it is suggested research in the scope of primary health care and maternity for the qualification of professionals working in the line of care for pregnant women and their families.
Co-production of blaNDM-1 and blaOXA-23 in multiresistant clinical isolates of Acinetobacter baumannii from Brazil
Authors: Lopes Maria Carolina Soares , Évora Bruna Helena Silva Rendall , Oliveira Claúdio Bruno Silva de , Oliveira Emília Sousa de , Melo Maria Celeste Nunes de
Published: July 2022

Acinetobacter baumannii is a common and dangerous non-fermenting gram-negative bacillus due to its various and increasing resistance mechanisms. Therefore, the objective of the work was to describe four NDM-1 -producing Acinetobacter isolates from Natal, northeastern Brazil. These four isolates were identified as Acinetobacter baumannii by MALDI-TOF. All isolates were characterized by antimicrobial susceptibility testing, with resistance to all β-lactams including carbapenems and positive for the synergy test with Ethylenediaminetetraacetic acid. PCR analysis was also performed for blaNDM-1, blaVIM-1, blaIMP-1, blaOXA-23, blaOXA-24/40, blaOXA-51, blaOXA-58, and blaOXA-143 genes and showed positive for the blaNDM-1 and blaOXA-23 genes in all isolates and this result was confirmed by sequencing. This is the first case of Acinetobacter baumannii strains harboring blaNDM-1 gene isolated from northeastern Brazil. This description emphasizes the need for new prevention and control strategies of the dissemination of NDM-1-producing Acinetobacter, which are associated with a high mortality rate.
Domicílios multigeracionais: satisfação e dificuldades apresentadas por avós cuidadores de netos
Authors: Bragato Aline Guarato da Cunha , Elias Henrique Ciabotti , Abreu Manoela de , Assis Helia Morais Nomelini de , Paula Fabiana Fernandes Silva de , Garcia Luan Augusto Alves , Camargo Fernanda Carolina , Santos Álvaro da Silva
Published: July 2022

Objetivo: identificar aspectos de satisfação e dificuldades apresentadas pelos avós que assumem os cuidados com seus netos. Metodologia: estudo quantitativo, exploratório e descritivo, com avós de 60 anos ou mais, cuidadores de crianças e/ou pré-adolescentes, morando ou não em mesma unidade familiar, sem e/ou com a presença do (os) progenitor (es) ou pais adotivos, possuindo a responsabilidade do cuidado integral ou parcial de sujeitos com até 13 anos de idade. Foi utilizado um instrumento com questões sobre satisfação e questões sobre dificuldades no cuidado do avô ao neto, elaborado pelos próprios autores e validado por face e conteúdo. Foi empreendida análise exploratória descritiva das variáveis, sendo realizada análise de frequência absoluta e relativa. Resultados: a grande maioria estão satisfeitos com o cuidado dos netos se sentindo felizes e motivados. Dentre as dificuldades apontadas estão o cansaço e estresse em decorrência do cuidado prestado. Conclusão: Os achados demonstram subsídios relevantes para inclusão desta pauta em Políticas Públicas, de forma a não prejudicar sua saúde, vida social e qualidade de vida.
Potenciais econômicos para o desenvolvimento sustentável do estado do Amazonas-AM
Authors: Silvestrim Eneida Guerra , Vieira Michael Raphael Soares , Reis Arnaldo Souza dos , Lima Filho Arlindo Almeida de , Silvestrim Fernanda Guerra , Silvestrim Rafael Guerra , Santos Maria do Carmo Neves dos , Duvoisin Júnior Sérgio , Costa Graciete Guerra da , Santana Genilson Pereira
Published: July 2022

O desenvolvimento econômico do estado do Amazonas teve o seu processo histórico caracterizado por uma economia baseada em ciclos econômicos, que se iniciou com a extração da borracha natural, até a criação do modelo do Polo Industrial de Manaus – PIM que permanece como a mais importante atividade econômica desenvolvida no estado, expondo a necessidade da diversificação da sua economia. Diante disso, o objetivo desta pesquisa é verificar a situação atual de algumas atividades econômicas, nas diferentes sub-regiões do Amazonas, identificando suas vocações regionais, os entraves que dificultam seu desenvolvimento e suas possíveis soluções que possibilitem o desenvolvimento sustentável do estado do Amazonas. Trata-se de uma pesquisa de classificação teórico empírico, com natureza tanto qualitativa quanto quantitativa em um nível de pesquisa descritiva. O desenvolvimento de outras matrizes econômicas como os setores de agricultura familiar, aquicultura, manejo florestal, turismo, crédito de carbono, implementação do Zoneamento Ecológico-Econômico (ZEE), polo de fertilizantes e o monitoramento dos recursos hídricos, incentiva o crescimento econômico do estado promovendo a elevação do PIB e a economia de cada município, possibilitando o incremento da produção interna e o desenvolvimento local. Entretanto, o desenvolvimento desses novos potenciais econômicos demanda tempo e recursos e dependem da vontade política. Logo, a criação de um plano governamental que vise o desenvolvimento do estado do Amazonas se mostra neste momento, emergencial com ações e serviços voltados para o desenvolvimento sustentável.
A Escuta Especializada nos inquéritos policiais registrados em uma delegacia de polícia de Belém, Pará, Brasil
Authors: Magalhães Natasha de Fátima Silva Reis , Cunha Katiane da Costa
Published: July 2022

Objetivo: O objetivo foi analisar o atendimento de crianças e adolescentes vítimas de violência sexual, nos inquéritos policiais instaurados na Delegacia Especializada no Atendimento a Criança e Adolescente/ ParáPaz Integrado Santa Casa de Misericórdia; identificar o quantitativo de indiciamentos gerados neles, face a lei que estabelece o Sistema de Garantias de Direito da criança e adolescente vítima de violência sexual. Metodologia: Estudo documental, descritivo, quantitativo. Variáveis: inquérito policial - oitiva da vítima, faixa etária, indiciamento; escuta especializada: etapas, forma documental, relato escuta. Resultados: O atendimento social se deu em 68,75%, 2016; 53,57%, 2017 e 21,05%, 2018. Em 2016, 43,75% das vítimas foram ouvidas, após escuta protegida; 2017, 25%; 2018,13,16%. 21,05% tinham 13 anos. Encaminhamentos para delegacia especializada de 25,56%; 23,68% para atendimento psicológico. 43,75% de indiciamentos, em 2016; 42,86%, 2017; 57,89%, 2018. Conclusão: A Escuta Especializada é feita pelo Serviço Social. A vítima foi chamada a prestar nova declaração, contrariando a lei da escuta.
Desempenho zootécnico de Tilápia Imperial Gift criada em sistema de Bioflocos sob diferentes densidades
Authors: Silva Raniell Ribeiro da , Bezerra Vitor Alves , Melo José Douglas G
Published: July 2022

O sistema de BFT trata-se de uma das opções de tecnologia acessíveis aos produtores aquícolas para se intensificar e reduzir os impactos ambientais causados pela emissão de efluentes ricos em matéria orgânica. O princípio desta tecnologia é reciclar nutrientes através de uma elevada relação carbono/nitrogênio na água, suplementando os organismos cultivados. Portanto, o objetivo do presente estudo é avaliar o desempenho zootécnico da Tilápia Imperial Gift sob diferentes adensamentos em sistema de BFT. O experimento foi realizado no núcleo urbano de Redenção – Pará, os 500 alevinos de Tilápia Imperial Gift revestidos sexualmente à machos. Para avaliação do desempenho zootécnico dos peixes foram utilizadas balança e régua, mensurando peso médio final, sobrevivência, conversão alimentar aparente, tamanho médio e biomassa total. A utilização da tecnologia de BFT na fase de berçário mostrou-se uma opção alternativa aos produtores rurais, tendo bons índices de conversão alimentar devido a presença de agregados microbianos. A fase de juvenis com adensamento de 66 peixes/m3 com peso médio final de 200g alimentados com 36% PB apresentou bons índices zootécnicos, permitindo minimizar o tempo de cultivo do pescado.
ANALYSIS OF THE JALAWASTU AREA AS A SUSTAINABLE CULTURAL TOURISM
Authors: Mukhlis Jafar , De Costa Stevie Louise Estella
Published: July 2022

Cultural tourism offers culture in the form of tourist objects that are tangible or concrete, intangible or abstract, as well as those that are living culture and cultural heritage. The potential of the Jalawastu Area has unique cultural values such as traditional ceremonial events and traditions that are still being maintained. This study aims to see the Jalawastu Area as a cultural tourism destination in Brebes Regency. The research method used is a descriptive method that aims to describe or describe phenomena or relationships between the phenomena being studied systematically, factually, and accurately (Kusmayadi, 2000). In addition, the descriptive method is a way of analyzing comprehensive data in the framework of explaining the conditions or characteristics of an area that occur as a particular consideration according to Densin. Based on the results of the analysis, the conclusion is that the development of the tourism heritage area of the Jalawastu Cultural Village has great potential as a cultural tourism destination, and the aspect of the analysis and culture that is owned by the existence of the Jalawastu Cultural Village has a unique architecture encourages the creation of a unique and distinctive domestic image. If the Jalawastu Cultural Village is developed with good management and planning, it will encourage the formation of a tourism heritage area with the main attraction being a tourist attraction for traditional ceremonies and traditional arts as historical and cultural tourism. The research recommendations include: on the product side, improving quality in the packaging of cultural and artificial products in the tourism heritage of the Jalawastu Cultural Village in an attractive tour package, adding supporting activities such as the tangible and tangible potential of Brebes Regency in the tourism area of the Jalawastu Cultural Village as a symbol To introduce the Brebes area as a whole to domestic and foreign tourists, the program is to innovate for the heritage tourism attractions of the Jalawastu Cultural Village to make it more attractive.
DETERMINATION OF WATER QUALITY INDEX (WQI) CENTRAL JAVA PROVINCE WATER BODY BASED ON TOTAL COLIFORM
Authors: Septiariva Iva Yenis , Matin Hashfi Hawali Abdul , Sari Novi Kartika , Sarwono Ariyanti , Suryawan I Wayan Koko
Published: July 2022

In recent years, the Central Java Province municipal river's water quality in the area is classified as heavily polluted. Therefore, research on water quality and its pollution level needs to be carried out in the Surakarta municipal river, especially in the Central Java Province. This study aimed to determine water quality and the pollution conditions in the Surakarta municipal river and analyze the conditions of the pollution load in the river at a predetermined observation point. This research was conducted using a survey method field with secondary data. The analysis was carried out using the method water quality index (WQI). The results showed The WQI change from heavily polluted to lightly polluted was measured at several observation locations from 2016 to 2018. The changes in the measured pollution index from 2016 to 2018 by coliform.
LOW CARBON CONCRETE: CEMENT REPLACEMENT UTILIZING FLY ASH
Authors: Langga Chandra Galuh Dimas , Shulhan M Afif , Yasin Iskandar , Sukiyono Sukiyono
Published: July 2022

Reducing the cement content in concrete is the need for environmental sustainability, as cement produces a significant carbon emission. This work aims to study the effect of partial replacement of the cement utilizing fly ash at the various percentage of substitution by investigating the physical characteristic of concrete ingredients, compressive testing at various curing age, workability, and material cost reduction. Fly ash used in this research is categorized as type F, which obtained from Jepara powerplant. Along with fly ash, ordinary pozzolan cement (OPC) from Semen Gresik used as binder material. The fine and coarse aggregates quarried consecutively from Magelang Regency and Kulon Progo Regency, Indonesia. All the constitutes being observed on specific gravity, gradation test, clay lumps content, and abrasion resistance. The job mix formula developed adopting Indonesian Standard based on the physical data obtained previously, resulting in five levels of cement replacement which is 0%, 15%,20%, 25%, and 30% compared to cementitious weight. Concrete cylinder specimen having 150 mm on the diameter and length of 300 mm, tested at various age (7,14, and 28 days) to obtained compressive strength and strength development during curing age. The current works remarks that all level of replacement obtained a good agreement with targeted compressive strength (25 MPa) at the age of 14 days. However, the more fly ash supplemented in the mixture, strength development possesses a slower rate and a slight declining on workability. Eventhough the slump value still comply with the requirement given by the Indonesian Standard.
Upaya Pengentasan Kemiskinan Melalui Layanan Lembaga Keuangan Mikro dan Program Pemberdayaan Perempuan di Kecamatan Rajapolah Kabupaten Tasikmalaya
Authors: Marino Wilman San , Gunawan Gun Gun
Published: July 2022

Abstract. The purpose of this research is to analyze the effect of microfinance services and women's empowerment programs on poverty reduction. The research method used in this research is quantitative research methods. Data analysis using simple mediation analysis by Hayes. The sample of this study was 130 women who received microfinance in the Rajapolah District, Tasikmalaya Regency. The results indicate that there was a significant influence between the variables of microfinance institution's service and women's empowerment on poverty reduction, and the variable women's empowerment programs mediated the effect of microfinance services on poverty reduction. The implication of this research is that achieving development goals in the form of poverty reduction and women's empowerment can be achieved by increasing the quantity and quality of microfinance institutions' services.Keywords: Microfinance Institutions; Poverty Reduction: Women empowermentAbstrak.Penelitian ini bertujuan untuk menguji pengaruh layanan lembaga keuangan mikro dan program pemberdayaan perempuan terhadap pengentasan kemiskinan. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian kuantitatif. Pengujian model menggunakan simple mediation analisys by Hayes. Sample dari penelitian ini sebanyak 130 orang perempuan yang mendapatkan pembiayaan mikro di Kecamatan Rajapolah Kabupaten Tasikmalaya. Penelitian menunjukan hasil bahwa terdapat pengaruh yang signifikan antara variable layanan lembaga keuangan mikro dan pemberdayaan perempuan terhadap pengentasan kemiskinan, serta variable pemberdayaan perempuan memediasi pengaruh layanan lembaga keuangan mikro terhadap program pengentasan kemiskinan. Implikasi dari penelitian ini adalah untuk mencapai tujuan pembangunan berupa pengentasan kemiskinan dan pemberdayaan perempuan dapat dicapai dengan meningkatkan kuantitas dan kualitas layanan lembaga keuangan mikro.Katakunci: Lembaga Keuangan Mikro; Pemberdayaan Perempuan;Pengentasan Kemiskinan
Lexical Hedges in Reflecting Gender Differences
Authors: Sabhagani Ayu Amartha , Malini Ni Luh Nyoman Seri , Saientisna Made Detriasmita
Published: July 2022

The study discusses lexical hedges in reflecting gender differences through the movie and analyzes the features of lexical hedges used in Sierra Burgess Is a Loser movie. The data were processed by categorizing the data into components of lexical hedges based on the framework of hedges proposed by Namasaraev (1997) and the sequential positions of lexical hedges proposed by Rosanti&Jaelani (2016). The use of nine types of lexical hedges conforming to its classification by the male and female characters showed a different number of results. As a result, female characters tend to more used lexical hedges rather than men characters. The female characters were mostly used lexical hedges as fillers yeah in their utterance to show their feelings, emotion, or opinion in the movie. The total data showed the number of female characters in using lexical hedges was 92 words sequentially from the most commonly used, i.e. fillers, lexical verbs, modal auxiliary verbs, adverb of frequency, adverb, and noun. Meanwhile, male characters used 40 words of lexical hedges and fillers as the most commonly used hedges through the word; like. In this movie, there were two sequential positions of lexical hedges, namely; the initial and medial position. Besides that, the female characters had a wide range of types in uttering the words that contained lexical hedges, whereas the male characters were not too often in selecting the words of lexical hedges. Penelitian ini membahas mengenai penggambaran lexical hedges dalam perbedaan gender melalu isebuah film, serta untuk menganalisis fitur lexical hedges yang digunakan dalam film Sierra Burgess Is a Loser. Data sudah diproses dengan mengkategorikan data menjadi komponen lexical hedges berdasarkan kerangka hedges yang disusun oleh Namasaraev (1997) dan posisi sekuensial lexical hedges yang diusulkan oleh Rosanti & Jaelani (2016). Penggunaan dari sembilan tipe lexical hedges berdasarkan klasifikasi oleh karakter pria dan wanita menampilkan hasil yang berbeda. Hasilnya, karakter wanita cenderung menggunakan lexical hedges dibandingkan dengan karakter pria. Karakter wanita paling sering menggunakan fitur lexical hedges sebagai fillers yaitu; yeah dalam ucapan mereka untuk menunjukkan perasaan, emosi, dan opini di dalam film. Total data menunjukkan penggunaan lexical hedges oleh karakter wanita berjumlah 92 kata yang secara beruratan dari yang paling sering digunakan yakni fillers, lexical verbs, modal auxiliary verbs, adverb of frequency, adverb, dan noun. Sedangkan, karakter pria menggunakan 40 kata lexical hedges dan fillers like sebagai fitur hedges yang paling sering digunakan. Di dalam film ini, terdapat dua posisi sekuensial dari lexical hedges yakni posisi awal dan posisi tengah. Disamping itu, karakter wanita memiliki jangkauan yang luas mengenai tipe-tipe dalam penyampaian kata yang mengandung fitur lexical hedges, sedangkan karakter pria tidak terlalu sering menggunakan kata lexical hedges didalam pemilihan kata
Additions to the Apsheron Flora
Authors: Mirzayeva Sh.
Published: July 2022

The article provides additional information on the species composition of the flora of the Apsheron Peninsula. The landscape of the peninsula is divided into two unequal parts, which differ orographically. Most of it is represented by the foothills and is located to the west of the peninsula, and a small eastern part is a flat semi-desert — the maximum height is 34 m. Covers natural and artificial ecosystems (semi-desert, middle and low mountain ranges, mud volcanoes, sand dunes and hills, arable lands, settlements). The synanthropic flora was formed here under the influence of anthropogenic factors, and its further adventization is underway. The article includes information about 14 herbarium species, previously common in Apsheron, but not included in the list of flora due to lack of information, and the range and general characteristics of 1 new species. Thus, the number of species distributed on the peninsula reaches 692, which are combined into 385 genera.
Role of the Relief and Climate Factors in Formation of Soil and Plant Cover in the Mugan-Salyan Cadastre Region
Authors: Mammadova G.
Published: July 2022

Collected and analyzed data on soil, ecological, climatic and relief conditions of the Mugan-Salyan cadastre region. The study of relief-climatic factors in the formation of soil and vegetation was carried out on the basis of both literary sources and our own research.
Crop Yield Comparative Analysis of Different Cotton-plant Varieties
Authors: Zeynalova F.
Published: July 2022

The study of economically valuable indicators of cotton varieties and their use in farms is quite important in measures to increase the crop performance and improve product quality. At present, it is important to compare the quantitative and qualitative indicators of cotton-plant varieties introduced from geographically distant countries cultivated in cotton-growing farms and to find out which of them are preferable and introduce them in farms. The Ganja-110 cotton-plant variety is better adapted to the soil and climatic conditions of Azerbaijan.
Role of Gut Microbiota in Cannabinoid-Mediated Suppression of Inflammation
Authors: Varsha Kontham Kulangara , Nagarkatti Mitzi , Nagarkatti Prakash
Published: July 2022

Cannabinoids and the endocannabinoid system have been well established to play a crucial role in the regulation of the immune response. Also, emerging data from numerous investigations unravel the imperative role of gut microbiota and their metabolites in the maintenance of immune homeostasis and gut barrier integrity. In this review, we concisely report the immunosuppressive mechanisms triggered by cannabinoids, and how they are closely associated with the alterations in the gut microbiome and metabolome following exposure to endogenous or exogenous cannabinoids. We discuss how cannabinoid-mediated induction of microbial secondary bile acids, short chain fatty acids, and indole metabolites, produced in the gut, can suppress inflammation even in distal organs. While clearly, more clinical studies are necessary to establish the cross talk between exo- or endocannabinoid system with the gut microbiome and the immune system, the current evidence opens a new avenue of cannabinoid-gut-microbiota-based therapeutics to regulate immunological disorders.
Long Non-Coding RNA LINC01929 Facilitates Cell Proliferation and Metastasis as a Competing Endogenous RNA Against MicroRNA miR-1179 in Non-Small Cell Lung Carcinoma
Authors: Pan Tinghong , Wang Hui , Wang Shuai , Liu Feng
Published: July 2022

Introduction: Non-small cell lung carcinoma (NSCLC) constitutes most lung cancers and has a poor prognosis. LncRNAs are a potential repository for the discovery of cancer prognostic markers. This study explored the role of LINC01929 in NSCLC, both the clinical prognostic significance and the mechanism of its influence on cells.

Materials and Methods: LINC01929 levels in 143 pairs of NSCLC tissues and non-cancerous tissues were detected by RT-qPCR. Kaplan-Meier curves and multivariate Cox regression assays were generated for evaluating the prognostic values of LINC01929. To evaluate the cellular function, an XTT assay and transwell invasion assays were performed.

Results: LINC01929 was up-regulated in NSCLC tissues compared with healthy tissues. A positive correlation was observed between LINC01929 expression level and tumor T (p = 0.002) or N stage (p = 0.010). Patients with higher LINC01929 levels had shorter overall survival (p = 0.009). Compared with other factors, high LINC01929 expression was significantly associated with poor survival in univariate Cox analysis (HR: 2.485, 95%CI: 1.220–5.060, p = 0.012). After multivariate Cox regression assays, LINC01929 was a independent prognostic factor (HR: 3.021, 95%CI: 1.377–6.628, p = 0.006). miR-1179 was a target miRNA of LINC01929. Inhibited expression of LINC01929 significantly reduced the proliferation, migration, and invasion of NSCLC cells by targeting miR-1179.

Discussion: This study revealed the upregulation of LINC01929 in NSCLC. This study supports previous studies showing LINC01929 as a potential prognostic factor for NSCLC.
An Ultraweak Variational Method for Parameterized Linear Differential-Algebraic Equations
Authors: Beurer Emil , Feuerle Moritz , Reich Niklas , Urban Karsten
Published: July 2022

We investigate an ultraweak variational formulation for (parameterized) linear differential-algebraic equations with respect to the time variable which yields an optimally stable system. This is used within a Petrov-Galerkin method to derive a certified detailed discretization which provides an approximate solution in an ultraweak setting as well as for model reduction with respect to time in the spirit of the Reduced Basis Method. A computable sharp error bound is derived. Numerical experiments are presented that show that this method yields a significant reduction and can be combined with well-known system theoretic methods such as Balanced Truncation to reduce the size of the DAE.
Dielectrophoretic Traps for Efficient Bead and Cell Trapping and Formation of Aggregates of Controlled Size and Composition
Authors: Lipp Clémentine , Koebel Laure , Bertsch Arnaud , Gauthier Michaël , Bolopion Aude , Renaud Philippe
Published: July 2022

We present a microfluidic dielectrophoretic-actuated system designed to trap chosen single-cell and form controlled cell aggregates. A novel method is proposed to characterize the efficiency of the dielectrophoretic trapping, considering the flow speed but also the heat generated by the traps as limiting criteria in cell-safe manipulation. Two original designs with different manufacturing processes are experimentally compared. The most efficient design is selected and the cell membrane integrity is monitored by fluorescence imaging to guarantee a safe-cell trapping. Design rules are suggested to adapt the traps to multiple-cells trapping and are experimentally validated as we formed aggregates of controlled size and composition with two different types of cells. We provide hereby a simple manufactured tool allowing the controlled manipulation of particles for the composition of multicellular assemblies.
Regulation of Neutrophil NADPH Oxidase, NOX2: A Crucial Effector in Neutrophil Phenotype and Function
Authors: Paclet Marie-Hélène , Laurans Salomé , Dupré-Crochet Sophie
Published: July 2022

Reactive oxygen species (ROS), produced by the phagocyte NADPH oxidase, NOX2, are involved in many leukocyte functions. An excessive or inappropriate ROS production can lead to oxidative stress and tissue damage. On the other hand, an absence of ROS production due to a lack of a functional NADPH oxidase is associated with recurrent infections as well as inflammation disorders. Thus, it is clear that the enzyme NADPH oxidase must be tightly regulated. The NOX2 complex bears both membrane and cytosolic subunits. The membrane subunits constitute the flavocytochrome b558, consisting of gp91phox (Nox2) and p22phox subunits. The cytosolic subunits form a complex in resting cells and are made of three subunits (p47phox, p40phox, p67phox). Upon leukocyte stimulation, the cytosolic subunits and the small GTPase Rac assemble with the flavocytochrome b558 in order to make a functional complex. Depending on the stimulus, the NADPH oxidase can assemble either at the phagosomal membrane or at the plasma membrane. Many studies have explored NOX2 activation; however, how this activation is sustained and regulated is still not completely clear. Here we review the multiple roles of NOX2 in neutrophil functions, with a focus on description of its components and their assembly mechanisms. We then explain the role of energy metabolism and phosphoinositides in regulating NADPH oxidase activity. In particular, we discuss: 1) the link between metabolic pathways and NOX2 activity regulation through neutrophil activation and the level of released ROS, and 2) the role of membrane phosphoinositides in controlling the duration of NOX2 activity.
Modulating the Electron Transporting Properties of Subphthalocyanines for Inverted Perovskite Solar Cells
Authors: Labella Jorge , Momblona Cristina , Čulík Pavel , López-Serrano Elisa , Kanda Hiroyuki , Nazeeruddin Mohammad Khaja , Torres Tomás
Published: July 2022

The lack of organic non-fullerene ETMs with good electron transport and device stability is an important problem for the further development and commercialization of perovskite solar cells. Herein, the use of SubPcs as ETMs in PSCs is explored. To this end, we analyze the influence of SubPc peripheral functionalization on the efficiency and stability of p-i-n PSCs. Specifically, ETMs based on three SubPcs (with either six or twelve peripheral fluorine and chlorine atoms) have been incorporated into PSCs with the perovskite layer deposited by solution processing (CsFAMAPbIBr). The device performance and morphology of these devices are deeply analyzed using several techniques, and the interfacial effects induced by the SubPcs are studied using photoluminescence and TR-PL. It is observed that the device stability is significantly improved upon insertion the SubPc layer. Moreover, the impact of the SubPc layer-thickness is assessed. Thus, a maximum power conversion efficiency of 13.6% was achieved with the champion device.
Synergetic Effect of Mo, Mg-Modified Sn-β Over Moderate-Temperature Conversion of Hexose to Alkyl Lactate
Authors: Hu Yanru , Zhang Gengrui , Liu Lele , Chi ZiXin , Wang Shuai , Lin Jingdong , Xiong Haifeng , Wan Shaolong
Published: July 2022

The thermocatalytic conversion of hexose into valuable chemicals such as methyl lactate under mild conditions is very appealing. Here, we report that Mo, Mg co-modified Sn-β catalyst can effectively catalyze the transformation of glucose and fructose into alkyl lactate at moderate temperatures. A maximum yield of around 35% of methyl lactate was achieved from the conversion of glucose in methanol at 100°C over Sn-β catalyst modified with 3 wt% Mo and 0.5 wt% Mg. However, up to 82.8% yield of ethyl lactate was obtained in the case of fructose in ethanol upon the same catalytic condition, suggesting a significant solvent effect. The Mo species plays a key role to enable the retro-aldol condensation of fructose, in which the competing side reactions are significantly suppressed with the assistance of neighboring Mg species probably through a synergetic effect of Lewis acid-base.
Insights on Guerbet Reaction: Production of Biobutanol From Bioethanol Over a Mg–Al Spinel Catalyst
Authors: Portillo Crespo M. A. , Vidal-Barrero F. , Azancot Lola , Reina Tomas Ramírez , Campoy M.
Published: July 2022

The production of biobutanol from bioethanol by the Guerbet reaction is an alternative pathway to renewable sources. The commercial viability of this green route requires improvements in the process development. This study experimentally examines the influence of operating conditions on the performance of a Mg–Al spinel catalyst prepared from hydrotalcite precursors. This catalyst demonstrates an exceptional performance in the Guerbet reaction with a promising activity/butanol selectivity balance, excellent long-term stability, and very-low-carbon footprint (CO2 generation as by-products is minimal). This study showcases a systematic strategy to optimize the reaction parameters in the Guerbet reaction for biobutanol production using an advanced spinel catalyst. Upon carefully adjusting temperature, pressure, space velocity, and reactants co-feeding, very promising conversion (35%) and butanol selectivity values (48%) were obtained.
The Use of Bumper Wire Technique and Intravascular Ultrasound for Precise Aorto-Ostial Stenting
Authors: Reddy Pavan K. V. , Daibes Joseph , Skaf Michel , Ochoa Roberto , Fujisaki Tomohiro , Lin Patricia , Patel Apurva , Kwan Tak
Published: July 2022

Background

Aorto-ostial interventions are challenging due to the limitations of contemporary equipment, imprecise ostial demarcation, and problematic ostial lesion characteristics. Suboptimal stent placement is common and portends worse clinical outcomes. Procedural and long-term outcomes of the bumper wire technique with intravascular ultrasound (IVUS) assessment have not been investigated.

Methods

A single-center retrospective study was conducted. Patients who underwent ostial lesion percutaneous coronary intervention (PCI) with the bumper wire technique between January 2019 and September 2020 were identified. The primary endpoint was to determine the geographic miss rate defined by inadequate ostial coverage or excess stent protrusion of > 2 mm by IVUS or angiography. The secondary endpoint was target lesion failure (TLF) at 6 months after PCI, defined as the composite of cardiovascular death, target vessel myocardial infarction (MI), and target lesion revascularization.

Results

In total, 45 patients were identified. The average age was 71.7 years old, and 85.4% were men. Indication for PCI was acute coronary syndrome in about a third of patients. Twenty-six patients had left main ostial lesions and 19 patients had right coronary artery ostial lesions. Geographic miss was detected in two patients (4.4%): one patient (2.2%) had excess proximal stent protrusion and one patient (2.2%) had an ostial miss. Six patients were lost to follow-up. TLF, stroke, or major bleeding were not observed in any of the patients.

Conclusion

The bumper wire technique is safe and efficient with low rates of geographic miss or adverse clinical outcomes. This is the first study to confirm precise aorto-ostial stent implantation with the bumper wire technique using IVUS confirmation.
Pore-Water Geochemical Gradients of Sulfate, Calcium, Magnesium, and Iodide Correlated With Underlying Gas Hydrate Potential: A Case Study of the Shenhu Area, South China Sea
Authors: Ai Xinyu , Zha Rihuan , Lai Yijun , Yang Tao , Su Pibo
Published: July 2022

Geochemical profiles in pore water of marine sediments have been considered as, important indicators of gas hydrate occurrence. In the gas hydrate area around the world, the decrease of sulfate, calcium, and magnesium concentrations with depth mainly results directly or indirectly from the anaerobic oxidation of methane (AOM). The ubiquitous abnormally high concentration gradients of iodide in the research area reflect the large methane-generating potential of the area. Thus, we explore the feasibility of using gradients of sulfate, iodide, and authigenic carbonate precipitation as indicators for gas hydrate in the regional exploration of gas hydrate formation. We test the criterion in the gas hydrate zone in the South China Sea (SCS) for the recognition of gas hydrate by using the gradients of sulfate, calcium plus magnesium, and iodide. Contour maps of pore-water gradients from expeditions in the study area are used to correlate the key gradients to underlying gas hydrate occurrence. The results show that the largest potential gas hydrate indicated by the contour maps of the indicators are well consistent with the discovery of GMGS1 and GMGS3 expedition. It implies the possible applicability of this geochemical method in gas hydrate exploration. Also, we identify a promising area in the South China Sea for future gas hydrate investigations. It is the first collective application of the gradients of sulfate, calcium plus magnesium, and iodide to a gas hydrate terrane, especially to a large area of the SCS. We believe that the result of this research will benefit the future exploration of gas hydrate and will arouse a lot of interest from other researchers.
The effect of seepage flow on movable solid materials research in debris flow experiments
Authors: Yang Shun , Gao Meiben , Jiao Jiaxua , She Tao , Chen Kun
Published: July 2022

Debris flows is one of the most common natural disasters in mountainous areas, posing a seriously risk to local people’s life and property. It is fundamental basis to study the criteria for movement of solid materials subjected to seepage flow and surface flow for the purpose of prevent this hazard. Therefore, mechanical analysis methods and laboratory experiments were used to study the effect of seepage flow on movable solid materials in debris flow. First, the definition of movable solid materials was proposed. Then, a geological model of debris flow is established considering saturated seepage flow. Finally, through mechanical analysis, formulas for dynamical force and resistance force are derived. The results show that the dynamical force and resistance force increase linearly with depth when the geologic model is homogenous and the seepage flow saturates the entire debris layer. It also indicated that pore-water pressure is one of the most important factors for causing debris flow, especially when the slope angle exceeds 12°. Through comparing the results of tests and theoretical analysis under saturated seepage flow, the discrepancy is only 1.3%–24.2%, showing that the formulas are fairly reliable. The motion of the solid materials should be described as a mechanical problem rather than a statistic qualitative description. The research contributes to the source volume calculation of small debris-flow watersheds and advances the study of the movable solid materials in complex dynamic conditions.
Prognosis of Congenital Anomalies in Conceptions Following In Vitro Fertilization: A Multicenter Retrospective Cohort Study in China
Authors: Bao Jie , Chen Lixue , Hao Yongxiu , Wu Hongping , He Xiaojin , Lu Chuncheng , Ji Xinhua , Qiao Jie , Wang Yuanyuan , Chi Hongbin
Published: July 2022

Background

Conceptions following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) have an increased risk of congenital anomalies. Few studies have explored the prognosis of fetuses with congenital anomalies. This study aimed to investigate the prevalence and prognosis of congenital anomalies in IVF/ICSI pregnancies, and to analyze the influencing factors contributing to poor prognosis.

Methods

In this multicenter retrospective cohort study, we followed 405,473 embryo transfer cycles at 15 reproductive centers between January 2010 and December 2019 and enrolled 2,006 intrauterine pregnancies with congenital anomalies. The relatively positive prognosis group with one or more live births and neonatal survival for more than 7 days was compared with the poor prognosis group with poorer outcomes.

Results

Among the 168,270 ongoing intrauterine pregnancy cycles, the prevalence of congenital anomalies was 1.19%, wherein the malformation rates of cycles with late abortion and delivery were 2.37% (716/30,202) and 0.93% (1,290/138,068), respectively. Among all IVF/ICSI cycles with congenital anomalies, the relatively positive prognosis rate was 61.39%. Moreover, the fertilization failure rate (2 pro-nuclei rate < 25%) in the poor prognosis group was significantly higher than that in the relatively positive prognosis group (10.89% vs. 5.09%, p < 0.001). Multivariate logistic regression analysis revealed no significant differences in the relatively positive prognosis rate among the various IVF/ICSI protocols. The relatively positive prognosis rate of fertilization failure cycles was 0.180 times that of normal fertilization cycles.

Conclusion

Poor fertilization rates during IVF/ICSI treatments are more likely to have poor prognosis in fetuses or neonates with congenital anomalies, and obstetric management should be strengthened in pregnant women, with which pregnant women should be recommended to strengthen obstetric management.
Testicular Sertoli Cell Hormones in Differences in Sex Development
Authors: Lucas-Herald Angela K. , Mitchell Rod T.
Published: July 2022

The Sertoli cells of the testes play an essential role during gonadal development, in addition to supporting subsequent germ cell survival and spermatogenesis. Anti-Müllerian hormone (AMH) is a member of the TGF-β superfamily, which is secreted by immature Sertoli cells from the 8th week of fetal gestation. lnhibin B is a glycoprotein, which is produced by the Sertoli cells from early in fetal development. In people with a Difference or Disorder of Sex Development (DSD), these hormones may be useful to determine the presence of testicular tissue and potential for spermatogenesis. However, fetal Sertoli cell development and function is often dysregulated in DSD conditions and altered production of Sertoli cell hormones may be detected throughout the life course in these individuals. As such this review will consider the role of AMH and inhibin B in individuals with DSD.