bluuebunny/crossref_metadata_2025 huggingface dataset:
Excellent Outcome of Immunomodulation or Bruton's Tyrosine Kinase Inhibition in Highly Refractory Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type
Authors: Gupta Eva , Accurso Joseph , Sluzevich Jason , Menke David M. , Tun Han W.
Published: December 2015

Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) is a rare diffuse large B-cell lymphoma confined to the skin of the legs. The typical presentation is characterized by solitary or multiple growing plaques, usually confined to one leg. We report a case of PCDLBCL-LT of activated B-cell subtype characterized by multiple local relapses in the legs, initially, and systemic relapses about seven years after the diagnosis. Local relapses were sensitive to radiation therapy. Cutaneous and systemic relapses responded well to immunomodulatory therapy with lenalidomide followed by Bruton's tyrosine kinase inhibition with ibrutinib. Ibrutinib is the only treatment that resulted in long-lasting complete remission. Lenalidomide and especially ibrutinib appear to have a significant activity against this lymphoma and should be incorporated in the treatment of this resistant and aggressive lymphoma. To our knowledge, this is the first case of PCDLBCL-LT reported in the literature exhibiting a complete response to ibrutinib.
Delaying Chemotherapy in the Treatment of Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer
Authors: Brufsky Adam M.
Published: December 2015

Global guidelines for the management of locally advanced or metastatic hormone receptor–positive (HR-positive), human epidermal growth factor 2-negative (HER2-negative) breast cancer recommend endocrine therapy as first-line treatment for all patients, regardless of age or postmenopausal status. However, current practice patterns in the United States and Europe suggest that these modes of therapy are not being used as recommended, and many patients with advanced HR-positive, HER2-negative disease are being treated first-line with chemotherapy or switched to chemotherapy after a single endocrine therapy. Given that chemotherapy is associated with increased toxicity and reduced quality of life (QOL) compared with endocrine therapy, prolonging the duration of response obtained with endocrine therapy may help delay chemotherapy and its attendant toxicities. Several strategies to delay or overcome endocrine resistance and thereby postpone chemotherapy have been explored, including the use of second-line endocrine agents with different mechanisms of action, adding targeted agents that inhibit specific resistance pathways, and adding agents that act in complementary or synergistic ways to inhibit tumor cell proliferation. This review analyzes the different therapy options available to HR-positive, HER2-negative patients with advanced breast cancer that can be used to delay chemotherapy and enhance QOL.
Об определении скачка функции обобщенной ограниченной вариации через производные от частных сумм ее ряда Фурье
Authors: Kelzon Andrei Anatoljevich
Published: December 2015

Установлено, что формулы для определения
скачка периодической функции через производные от частных сумм
ее ряда Фурье, справедливые для функций
гармонической ограниченной вариации (класс HBV),
могут потерять силу на классе функций $\Phi$-ограниченной вариации
(в смысле М. Шрамма), если этот класс шире класса HBV.
Библиография: 12 названий.
Об одном отношении двойственности для унитарных автоморфизмов в пространствах теплицевых и ганкелевых матриц
Authors: Abdikalykov Abdikozha Kozhanasiridinovich , Ikramov Khakim Dododzhanovich , Chugunov Vadim Nikolaevich
Published: December 2015

Отношением двойственности мы называем тождество между группами
унитарных автоморфизмов, действующих в пространстве теплицевых
или ганкелевых матриц посредством подобия или конгруэнции.
Дано простое объяснение причины появления таких тождеств.
Библиография: 6 названий.
Контактная форма Ли и конциркулярная геометрия локально конформно квази-сасакиевых многообразий
Authors: Kirichenko Vadim Fedorovich , Pol'kina Elena Alexandrovna
Published: December 2015

В представленной статье вводится в рассмотрение класс почти
контактных метрических структур, допускающих локально
конциркулярное преобразование в квази-сасакиеву структуру,
а именно, локально конциркулярно квази-сасакиевы
структуры. Получен критерий, позволяющий выделить подкласс
введенных структур из класса локально конформно
квази-сасакиевых структур. Получены
некоторые приложения и обобщения этого результата.
Библиография: 13 названий.
Role Language and Character Language
Authors: KINSUI Satoshi , YAMAKIDO Hiroko
Published: December 2015

Since Kinsui's (2000, 2003) initial proposal, research on role language has progressed with the topics growing more diverse. In this paper we propose that a peculiar speech style assigned to a certain character in fiction should be treated as character language rather than role language. Role language, which is based on social and cultural stereotypes, is a subset of character language. Given that role language is also a linguistic stereotype, its knowledge should be widely shared by members of the speech community, and its patterns within limits. Character language, on the other hand, allows for various types, being far from being a closed class. We examine and give examples of four types of character language: speech styles that could become actual role language, once shared widely in the speech community; speech styles that are effectively adopted by characters outside of their expected speaker's social and cultural groups; speech styles employed to represent something other than their stereotypes; and uniquely created speech styles.
Observations on Intra-Nebular Kyara Among Youth
Authors: SENUMA Fumiaki
Published: December 2015

This article summarizes the author’s book (Senuma 2007) on kyara in communication among young people in modern Japan, and subsequent research developments.Here, kyara refers to an intelligible, stereotypical abstraction, derived from a person’s prominent traits. Among the young generation, individuals are sometimes assigned a specific kyara by others in their peer group, regardless of that individual's intentions. Accepting and performing that kyara can elevate the mood of the situation, and become the occasion for communication and humour. This is a benefit of kyaras, but they have disadvantages as well. For example, it may be burdensome to perform that kyara, they might not like the kyara assigned by their friends, or they may be troubled by the disconnect between kyara and self. If kyara-based teasing turns into bullying, this can be a source of suffering for youths as well.The above trends have escalated since the publication of Senuma (2007). Situations in which young people should perform kyaras around their friends have increased. Moreover, the younger generation must increasingly use different kyara for different situations due to the popularization of smartphones and the ubiquity of various social networking sites.This “situational use of different selves” is contrary to the identity theory, which posits that people build a consistent self during adolescence. Human relationships and types of friendship are inherently varied, but to the young, fear of losing friends takes precedence, so they perform kyaras to fit in with their friends. If they become too accustomed to performing these kyaras, their innate right to change within their relationships to others could be stripped away by the group dynamic.
The Japanese language and character particles, as seen in dialect:
Authors: TOMOSADA Kenji
Published: December 2015

The article deals with the following three views and concludes that (1) the phenomenon in which a word related to the identity of the speaker (a sentence-ending particle with its origins in the first-person pronoun [“first-person sentence-ending particle” hereinafter]) appears after other sentence-ending particles may be observed in dialect; (2) the phenomenon in which a word related to the identity of the listener (a sentence-ending particle with its origins in the second-person pronoun [“second-person sentence-ending particle” hereinafter]) appears after other sentence-ending particles also may be observed in dialect; (3) the phenomenon of occurrence of the first-person sentence-ending particle at the end of the sentence has a different nature than the phenomenon of occurrence of the second-person sentence-ending particle at the end of the sentence.
Sandra Bohlinger, Ulrika Haake … (ur.) (2015). Working and learning in times of uncertainty. Rotterdam, Sense Publishers
Authors: Kelava Polona
Published: December 2015

V seriji Raziskovanje izobraževanja in učenja odraslih (Research on the Education and Learning of Adults) je letos v sodelovanju med založbo Sense in ESREA, združenjem raziskovalcev izobraževanja odraslih, izšla monografija o delu in učenju v negotovih časih. Naslov se približa naši lastni negotovosti, kako razumeti svojo prakso, kako jo razvijati, kako jo raziskovati.
Socioekonomski položaj samozaposlenih v kulturi: oris stanja v Sloveniji
Authors: Ograjenšek Irena , Perviz Lejla
Published: December 2015

V empirični študiji, izvedeni v zadnji tretjini leta 2012, smo analizirali položaj samozaposlenih v kulturi v Sloveniji. Poseben poudarek smo namenili preučevanju preživetvenih strategij. Kvalitativni del raziskave smo izvedli s pomočjo netnografije, spletnega intervjuja in osebnega intervjuja, kvantitativni del raziskave pa s pomočjo spletnega vprašalnika. Rezultati raziskave so pokazali, da aktualni način državne podpore samozaposlenim v kulturi ni ustrezen. Izboljšave so potrebne predvsem v smeri priznavanja večjih socialnih pravic, upoštevanja specifike poklica ter posebnih pogojev dela samozaposlenih v kulturi.
Critical reflections on managing cultural diversity in workplaces in Slovenia
Authors: Brezigar Sara
Published: December 2015

The paper focuses on managing cultural diversity at workplaces in Slovenia. The author critically reflects on some aspects of research and studies that have been carried out both on discrimination as well as managing diversity in Slovenia between 2007 and 2013, and finds the cause of the inability of organisations to adopt policies on managing diversity in the lack of competences and skills associated with cultural sensibility. The author maintains that whereas workplaces are bound to become more and more diverse, the predominant approach towards diversity in workplaces in Slovenia tends to either dismiss (cultural) diversity as inconsequential or treat it as a nuisance that needs to be dealt with, thus failing to grasp the advantages which such diversity could bring.
Kako izboljšati zavedanje starejših o tem, da so državljani Evrope? Brescia, 1.–8. oktober 2015
Authors: Findeisen Dušana
Published: December 2015

Laz, društvo za razvoj podeželja in regionalno stičišče, je v evropsko projektno sodelovanje DOCPIE pritegnil partnerje iz 13 držav, med drugim Univerzo v Brescii (it. Università degli Studi di Brescia). Na tej univerzi lahko med drugim študirate teorijo in metodologijo izobraževanja odraslih, družbene vede in psihologijo (upravljanje skupin, ponujanje psihološke pomoči v starajoči se družbi, sociologija starajoče se družbe) ter okoljske vede in tehnike. Za tiste med nami, ki so nam še zmeraj znanstvene vede bližje kot študijska področja, se takšen študij na prvi pogled ne zdi dovolj poglobljen, a vtis je, da s svojo interdisciplinarnostjo sledi razvoju družbe in njenim potrebam.
Vseživljenjskost učenja ter raziskovanje vzgoje in izobraževanja. Ob 50-letnici Pedagoškega inštituta
Authors: Jelenc Zoran
Published: December 2015

Letos praznuje Pedagoški inštitut 50 let delovanja, kar je za raziskovanje vzgoje in izobraževanja pomemben dogodek ter hkrati spodbuda za razmislek o raziskovanju vzgoje in izobraževanja z različnih zornih kotov. Sodelavcem Pedagoškega inštituta čestitam za njihovo dozdajšnje uspešno delo in jim želim uspešno nadaljevanje raziskovanj na področju vzgoje in izobraževanja. Sam sem šest let delal na tej ustanovi, ki sem jo nazadnje (leta 1991) moral zapustiti, ker vsebina mojega raziskovanja, to je raziskovanje izobraževanja odraslih in andragogike, ni bila kompatibilna z njenim programom. Strategija vseživljenjskosti učenja je tista, ki bo v prihodnosti zahtevala kompatibilnost raziskovanja obeh področij, to je vzgoje in izobraževanja otrok in mladine ter izobraževanja odraslih. Pedagoški inštitut ima pri tem dve možnosti: razviti sodelovanje med tema področjema v lastni instituciji ali vzpostaviti in razviti sodelovanje z institucijami, ki raziskujejo področje andragogike in izobraževanja odraslih.
John Henry Newman and the Oxford Movement: A Poet of the Church
Authors: Starčević Mirko
Published: December 2015

The paper examines John Henry Newman and the extent to which his involvement with the Oxford Movement influenced his poetic endeavours. The analysis of the historical and theological background of the Movement from Newman’s perspective makes the task of presenting the genesis of Newman’s poetic conceptions much easier. Newman was famous for being a preternaturally gifted preacher and prose writer, while his poetic texts received less attention. The examination of poetry is carried out here by contrasting the Oxford Movement’s ideas, majorly Newman’s own ideas and poetry, with Romanticism as the high guardian of Imagination and furor poeticus. While the Romantic poets craved authenticity and defied the laws of imitative modes of expression, the devotional poets of that time oftentimes leaned on mimesis. The paper’s objective, therefore, is to help define the prominence of imitative elements in Newman’s poetry and their impact on the quality of his verse.
Creative Thinking and Decision-Making Processes in EFL Creative Writing
Authors: Težak Katja
Published: December 2015

Creativity has been discussed, observed and researched for hundreds of years in the fields of psychology and philosophy – from the ancient notion of the inspired genius, all the way to modern psychologists trying to define creativity and prove its effects. Creativity has recently become a buzzword in EFL teaching practices. We try to stimulate creative thinking in the classroom, but possibly forget to observe the processes within it. The article discusses definitions of creativity and presents a qualitative study on the decision-making processes within EFL creative writing and its connections to students’ language learning. The qualitative study was conducted with two 3rd-year bachelor English students who were asked to plan and write a short story in English while doing a think-aloud protocol. The data were transcribed and coded in order to observe emerging categories in the students’ reasoning for plot and language use decisions.
Students of Today Changing English Language Studies of Yesterday
Authors: Vodopija-Krstanović Irena , Brala Vukanović Maja
Published: December 2015

In recent times, concern has been expressed as to whether English Language Studies are in tune with the wider social, political, technological and economic trends, and the latest developments in applied linguistics and English language education. In line with these views, the aim of this study is to explore – by means of interviews with 25 English majors from the University of Rijeka – the students’ expectations with respect to the skills and competencies (to be) developed in their course of English studies, their relevance to the job market, as well as the teaching approaches and methods used to reach these learning outcomes. By comparing and contrasting the emerging educational trends triggered by the Bologna Process with primary data collected in our interviews, we focus on the implications that our results might have in terms of introducing changes to traditional English Language Studies educational paradigms.
Translators: Travellers, Not Tourists
Authors: Rot Gabrovec Veronika
Published: December 2015

The article explores various representations of culture(s) found in contemporary English children’s literature and discusses how they were rendered into Slovene. In the first part, some introductory definitions of culture and approaches to the translation of children’s literature are presented. In the second part, excerpts from selected literary works (for instance, Mary Poppins, Harry Potter and the Philosopher’s Stone, Matilda, The Curious Incident of the Dog in the Night-Time) are examined, both from the source and the target texts, with more attention paid to the cultural contexts, and the social changes that possibly influenced the translator’s decisions.
Cardiff English: A Real Time Study of Stability and Change between Childhood and Mid-Adulthood
Authors: Mees Inger Margrethe , Osorno Christina Høøck
Published: December 2015

This article describes a real time panel study of a small number of working and middle class female speakers recorded in Cardiff at three points in time over a period of 35 years. The first recordings were made in 1977 when the informants were ten years old. The second date from 1990 when they were young adults, and the third from 2011 when they had entered into midadulthood. The linguistic variables investigated were h-dropping and the realisation of /r/ as an approximant or tap. Three issues were addressed. First, the two variables were categorised into indicators or markers/stereotypes on the basis of social and stylistic variation. This served as a basis for the second question, which was to discover if the patterns of change over time were in accordance with those predicted by the literature, with indicators remaining stable and markers/stereotypes being age-graded. Finally, we looked at individual variation.
LINFOMA PRIMARIO DEL SISTEMA NERVIOSO CENTRAL COMO PRIMERA MANIFESTACIÓN DE SIDA. PRESENTACIÓN DE UN CASO Y REVISIÓN DE LA LITERATURA
Authors: Corti Marcelo , Villafañe María F. , Franze Osvaldo , Campitelli Ana , Narbaitz Marina
Published: December 2015

El linfoma primario del sistema nervioso central (LPSNC) es una neoplasia infrecuente que comprende solo el 5% del total de los linfomas de localización extranodal. El LPSNC se define como un linfoma de tipo No Hodgkin (LNH) que solo infiltra el eje cerebro espinal sin compromiso sistémico. Esta neoplasia es más frecuente en sujetos con inmunodeficiencias congénitas y adquiridas. En los pacientes con SIDA, el LPSNC ocurre con igual incidencia en todos los grupos de riesgo y edades pero con una mayor prevalencia en aquellos con recuentos de linfocitos T CD4 + de < de 50 células/µL. Se trata de un linfoma de células grandes, de alto grado de malignidad, y fuertemente asociado en su patogenia al virus de Epstein Barr (VEB) cuyo genoma se detecta en las células linfoides atípicas. La presencia del genoma del VEB se detecta en el 100% de los casos de LPSNC asociado al SIDA pero esto no ocurre en otras clases de pacientes con esta misma neoplasia. En pacientes con SIDA y lesiones de masa cerebral ocupante, la detección del genoma del VEB en el líquido cefalorraquídeo (LCR) a través de la reacción en cadena de la polimerasa (PCR) tiene una sensibilidad del 83% a 100% y una especificidad > del 90% para el diagnóstico. El uso difundido de la terapia antirretroviral de gran actividad (TARGA) se asoció con una declinación en la incidencia de LPSNC. El pronóstico de esta neoplasia en pacientes con SIDA es pobre y se asocia con una mediana de supervivencia de 2 a 3 meses en la era previa a la TARGA con una discreta prolongación en la supervivencia con la TARGA. Se presenta un paciente que desarrolló un LPSNC como primera manifestación de SIDA y se efectúa una actualización de la literatura sobre el tema.
PROGRAMAS DE CONTROLE DA TOXOPLASMOSE CONGÊNITA: ESTUDO DA SITUAÇÃO ATUAL EM UM MUNICÍPIO BRASILEIRO
Authors: De Moura Fernanda Loureiro , Goulart Patrícia Riddell Millar , Sudré Adriana Pittella , Amendoeira Maria Regina Reis
Published: December 2015

As medidas de prevenção da toxoplasmose congênita podem ser implementadas em três níveis. A prevenção primária caracteriza-se por programas de educação e saúde pública, nos quais as gestantes suscetíveis recebem orientações sobre as fontes de infecção e como adotar medidas profiláticas. A secundária consiste no screening sorológico durante o pré-natal e a terciária tem como foco o recém-nascido já infectado buscando prevenir danos clínicos e complicações tardias. Este estudo teve por objetivo descrever a situação do controle da toxoplasmose congênita no município de Niterói-RJ de acordo com a Política Nacional de Promoção da Saúde. Neste município, está implantada a prevenção secundária da toxoplasmose congênita. Não há orientação sobre as medidas preventivas para gestantes soronegativas, como também não há notificação dos casos de toxoplasmose adquirida na gestação e congênita.
INQUÉRITOS COPROPARASITOLÓGICOS DE PARASITOS INTESTINAIS NA CIDADE DE LONDRINA-PR: UMA ANÁLISE RETROSPECTIVA
Authors: Bosqui Larissa Rodrigues , Sanfelice Raquel Arruda , Custódio Luiz Antonio , De Menezes Maria Cláudia Noronha Dutra , Murad Valter Abou , Diehl Leandro Arthur , Tano Zuleica Naomi , Pavanelli Wander Rogério , Conchon-Costa Ivete , Almeida Ricardo Sergio , Costa Idessania Nazareth
Published: December 2015

As parasitoses intestinais constituem importante problema de saúde pública, portanto é necessário informar à população acerca destas infecções, principalmente onde os dados são escassos. Este estudo teve como objetivo determinar a prevalência de parasitos intestinais com base na análise de prontuários de indivíduos provenientes da cidade de Londrina-PR. Foram analisados 11.641 prontuários de fevereiro de 2009 a dezembro de 2012. Os dados foram catalogados após a conclusão dos testes parasitológicos de Hoffmann, Pons & Janer, Faust e Kato-Katz. De 11.641 prontuários, 19,1% apresentaram resultados positivos para parasitos intestinais. Entre esses, 52,1% eram de indivíduos do sexo feminino e 47,9% do sexo masculino, com predomínio de positividade entre crianças de 0-10 anos (27,1%). Nas regiões estudadas, o norte destacou-se com 35,4% dos casos e prevalência de 6,8%. Entre os protozoários patogênicos, Giardia lamblia foi o mais relatado com 19,1% de positividade, os ancilostomídeos foram os mais frequentes entre os helmintos, com 7,8% de casos positivos. Conclui-se que condições precárias de saneamento básico contribuem para a disseminação destas parasitoses e o diagnóstico precoce é determinante para o sucesso do tratamento. Além disso, dados epidemiológicos são utilizados para o estudo dos fatores de risco de transmissão e podem resultar em medidas apropriadas para melhorar as condições de vida da comunidade.
PREVALÊNCIA DE PARASITOSES INTESTINAIS DE ACORDO COM O GÊNERO EM UM HOSPITAL UNIVERSITÁRIO NO SUL DO BRASIL
Authors: Bueno Greyce Christine Lisboa , Reis Marcellus , Corrêa Esther Buzaglo Dantas , Schiavon Leonardo De Lucca , Narciso-Schiavon Janaína Luz
Published: December 2015

Introdução: As parasitoses intestinais apresentam elevada morbimortalidade, especialmente em áreas endêmicas. O Brasil é um país de extrema heterogeneidade econômica e pouco se sabe sobre a prevalência de parasitoses intestinais na região Sul. O objetivo desse estudo é relatar a prevalência de parasitoses intestinais em exames de fezes, e avaliar se há diferenças em relação ao gênero. Métodos: Estudo de coorte histórico, analítico transversal, que avaliou exames parasitológicos de fezes (PPFs) realizados em laboratório de Hospital Universitário. Resultados: Foram incluídos 3.126 resultados de PPFs, onde 44,4% pertenciam a homens e 10,1% eram positivos. Protozoários comensais foram os mais frequentes (7,7%) e E. nana foi o mais prevalente (3,7%). Entre os patogênicos, o mais frequente foi G. lamblia (1,3%), seguido de S. stercoralis (0,7%). De uma forma geral, os homens apresentaram maior proporção de exames positivos (13,0% vs. 7,8%; P < 0,001), tanto para parasitos comensais (7,2% vs. 5,1%; P = 0,016), quanto para patogênicos (4,5% vs. 1,8%; P < 0,001); tanto para protozoários (10,7% vs. 6,4%; P < 0,001) quanto para nematodos (1,4% vs. 0,6%; P = 0,036). Igualmente, os homens apresentaram uma maior proporção de resultados positivos para E. nana (5,2% vs. 2,6%; P < 0,001), E. coli (3,5% vs. 1,6%; P < 0,001), G. lamblia (2,2% vs. 0,6%; P < 0,001) e S. stercoralis (1,1% vs. 0,3%; P = 0,013) quando comparados às mulheres. Conclusões: Parasitos foram encontrados em 10% dos exames, sendo os comensais mais prevalentes. Os homens exibiram maior proporção de enteroparasitoses que as mulheres.
Space and Species. Business School Exemplifications
Authors: Stańczyk-Hugiet Ewa , Strużyna Janusz , Piórkowska Katarzyna , Stańczyk Sylwia
Published: December 2015

The purpose of the paper is to contribute to develop, illustrate, and apply the concept of space management using facility performance from the evolutionary perspective in the public & non-public business school in Poland. The retrospective case study has been used so as to establish the context of the studies. In the public business school, space management has not been under the influence of environment external mechanisms reducing the growth of organizational space so far. Nevertheless, the research on the non-public business school authorized the statement that changes in environment explicitly influence the space occupied.Keywords: evolutionary approach, space management, facility management, species, routines
Reviewer Acknowledgements for International Education Studies, Vol. 9, No. 1
Authors: Lee Chris
Published: December 2015

Reviewer acknowledgements for International Education Studies, Vol. 9, No. 1, 2016.
Strategic Feeding Alternating a 2-months’ Feeding Restriction and a Short Boost of the Feeding Level Increases Conception Rate in Sheep
Authors: Lassoued Narjess , Rekik Mourad , Ben Salem Imene , Rouatbi Mariem
Published: December 2015

This study aimed to investigate if feeding patterns prior to and after artificial insemination (AI) affect the reproductive performances of ewes. Two breeds were used; the Barbarine (n = 133) and Queue Fine de l’Ouest (QFO; n = 129). For each breed, 2 experimental groups balanced for age and live weight were formed. For 75 days before AI, ewes in treatment High daily grazed for 6 hours and were supplemented with 0.6 kg of concentrate. For those in treatment Low-High, grazing was restricted to 3 hours only. From 21 days before insemination and the following 20 days, feeding pattern for Low-High ewes was switched to the High feeding regime. Changes in live weight and ovarian activity were monitored; conception rate and litter size were recorded. At the end of the restriction period and for both breeds, Low-High ewes reached lower live weights than High ewes (p < 0.05). Prior to AI and for both breeds, Low-High ewes weighed less than those in the High treatment group but no statistical differences were observed. At the end of the restriction period, more QFO ewes were cycling than for the Barbarine breed (75/129 vs. 55/133; p < 0.01). Further, less QFO ewes in the Low-High treatment were cycling than High ewes (30/65 vs. 45/64; p < 0.01). More QFO ewes conceived to AI than Barbarine counterparts (77/112 vs. 73/130; p < 0.05). For both breeds, higher proportions of ewes in the Low-High treatment groups conceived to AI but differences reached statistical significance only for Barbarine breed. Following a food-restriction period between weaning and mating, improved conception rates are achieved if the plane of nutrition is increased few weeks prior to and after AI in comparison to a continuous increase in live weight during the same period.
A Two-Step Model for Assessing Relative Interest in E-books Compared to Print
Authors: Knowlton Steven A.
Published: December 2015

Librarians often wish to know whether readers in a particular discipline favor e-books or print books. Because print circulation and e-book usage statistics are not directly comparable, it can be hard to determine the relative interest of readers in the two types of books. This study demonstrates a two-step method by which librarians can assess the appeal of books in various formats. First, a nominal assessment of use or nonuse is performed; this eliminates the difficulty of comparing print circulation to e-book usage statistics. Then, the comparison of actual use to Percentage of Expected Use (PEU) is made. By examining the distance between PEU of e-books to PEU of print books in a discipline, librarians can determine whether patrons have a strong preference for one format over another.
Metadata Effectiveness in Internet Discovery: An Analysis of Digital Collection Metadata Elements and Internet Search Engine Keywords
Authors: Yang Le
Published: December 2015

This study analyzed digital item metadata and keywords from Internet search engines to learn what metadata elements actually facilitate discovery of digital collections through Internet keyword searching and how significantly each metadata element affects the discovery of items in a digital repository. The study found that keywords from Internet search engines matched values in eight metadata elements and resulted in landing visits to the digital repository. Findings of the study indicate that three specific metadata elements are effective in enhancing discoverability of digital collections through Internet search engines, including Dublin Core metadata elements Title, Description, and Subject.
Employer Perceptions of Critical Information Literacy Skills and Digital Badges
Authors: Raish Victoria , Rimland Emily
Published: December 2015

Digital badges are an educational innovation used to measure learning of specific skills, such as information literacy. However, few studies have quantitatively surveyed employers for their perceptions about information literacy skills or digital badges. An online survey was developed and sent to employers to gauge perceptions of information literacy skills of college graduates and the use of the innovation of digital badges to represent competencies that students have accumulated. Here are the results of the survey: information literacy and metaliteracy skills are valued in the workplace; employers would like more detailed representations of student skills; and digital badges are a possible way to showcase student achievement.
Selected Topics on Advanced Information Systems Engineering: Editorial Introduction to the Issue 5 of CSIMQ
Authors: Grabis Janis , Sandkuhl Kurt
Published: December 2015

The 5th issue of the journal on Complex Systems Informatics and Modeling (CSIMQ) presents extended versions of five papers selected from the CAiSE Forum 2015. The forum was part of the 27th edition of international Conference on Advanced Information Systems engineering (CAiSE 2015), which took place in June 2015 in Stockholm, Sweden. Information systems engineering draws its foundation from various interrelated disciplines including, e.g., conceptual modeling, database systems, business process management, requirements engineering, human computer interaction, and enterprise computing to address various practical challenges in development and application of information systems. The guiding subjects of CAiSE 2015 were Creativity, Ability, and Integrity. The CAiSE Forum aimed at presenting and discussing new ideas and tools related to information systems Engineering.
Applying Idea Management System (IMS) Approach to Design and Implement a collaborative Environment in Public Service related open Innovation Processes
Authors: Alessi Marco , Camillò Alessio , Chetta Valentina , Giangreco Enza , Soufivand Mona , Storelli Davide
Published: December 2015

Novel ideas are the key ingredients for innovation processes, and Idea Management System (IMS) plays a prominent role in managing captured ideas from external stakeholders and internal actors within an Open Innovation process. By considering a specific case study, Lecce-Italy, we have designed and implemented a collaborative environment, which provides an ideal platform for government, citizens, etc. to share ideas and co-create the value of innovative public services in Lecce. In this study the application of IMS with six main steps, including: idea generation, idea improvement, idea selection, refinement, idea implementation, and monitoring, shows that this, remarkably, helps service providers to exploit the intellectual capital and initiatives of the regional stakeholders and citizens and assist service providers to stay in line with the needs of society. Moreover, we have developed two support tools to foster collaboration and transparency: sentiment analysis tool and gamification application.
Toward Better Mapping between Regulations and Operations of Enterprises Using Vocabularies and Semantic Similarity
Authors: Sunkle Sagar , Kholkar Deepali , Kulkarni Vinay
Published: December 2015

Industry governance, risk, and compliance (GRC) solutions stand to gain from various analyses offered by formal compliance checking approaches. Such adoption is made difficult by the fact that most formal approaches assume that a mapping between concepts of regulations and models of operational specifics exists. Industry solutions offer tagging mechanisms to map regulations to operational specifics; however, they are mostly semi-formal in nature and tend to rely extensively on experts. We propose to use Semantics of Business Vocabularies and Rules along with similarity measures to create an explicit mapping between concepts of regulations and models of operational specifics of the enterprise. We believe that our work-in-progress takes a step toward adapting and leveraging formal compliance checking approaches in industry GRC solutions.
Usability Evaluation of Variability Modeling by means of Common Variability Language
Authors: Echeverria Jorge , Font Jaime , Pastor Oscar , Cetina Carlos
Published: December 2015

Common Variability Language (CVL) is a recent proposal for OMG's upcoming Variability Modeling standard. CVL models variability in terms of Model Fragments.  Usability is a widely-recognized quality criterion essential to warranty the successful use of tools that put these ideas in practice. Facing the need of evaluating the usability of CVL modeling tools, this paper presents a Usability Evaluation of CVL applied to a Modeling Tool for firmware code of Induction Hobs. This evaluation addresses the configuration, scoping and visualization facets. The evaluation involved the end users of the tool whom are engineers of our Induction Hob industrial partner. Effectiveness and efficiency results indicate that model configuration in terms of model fragment substitutions is intuitive enough but both scoping and visualization require improved tool support. Results also enabled us to identify a list of usability problems which may contribute to alleviate scoping and visualization issues in CVL.
Strength and weakness of the totalitarianism in Wartime Soviet Union
Authors: Suprun Mikhail
Published: December 2015

Unlike all other countries of the Barents Area, Russia found itself in a very specific situation. At the beginning of the war it entered into the alliance with the Axis, while from 1941 it continued the war in the Anti-Hitler coalition. But the main distinctive feature of the wartime Russia was the transformation of its policy. Not a single state in the world history had reached such a degree of centralization as the Soviet Union did during the Second World War. Along with an extremely high degree of centralization of the political system, the Soviet state completely subdued the economy in order to solve the main problem of the moment – to mobilize maximum resources in the shortest period of time in order to win the war. During the war it could be done only at the expense of the population’s welfare.As a result, during only the first months of the war the Soviet Union managed to compensate its huge losses in manpower, weapons and technology. At the same time, providing the population with food and manufactured goods had been reduced to the absolute minimum. Sometimes – less than the minimum. In some cities, e.g. Arkhangelsk, famine broke out. Soon it was followed by outbreaks of epidemics and high mortality.In order to avoid epidemics which threatened to develop into a pandemic that could spread into the army, the authorities were forced to take drastic measures to improve the healthcare system by including almost the entire population of the country in sanitary training. Control of the epidemic situation became another domestic front for Russia.Largely thanks to the strict centralization, the government managed to mobilize the population for victory at this "home front". At least in the Northern areas they managed to extinguish outbreaks of epidemic diseases, while several diseases were minimized or even eliminated by the end of the war. It is this particular nature of the Soviet totalitarianism and its manifestation in the North that is the research topic in Suprun’s article.
Wavelet analysis of polar vortex variability over the twentieth century
Authors: Glovin Grant M. , Arbetter Todd E. , Lynch Amanda H.
Published: December 2015

Recent increases in extreme weather events in the Northern Hemisphere have been linked to amplified planetary waves. Changes in planetary wave properties are linked to changes in climate; hence, finding a mechanism that links the planetary wave variability under climatic forcing and midlatitude blocking events has engendered a great deal of interest. In this study, wavelet analysis is applied to time series of planetary wave phase speeds at high latitudes as a first step to assessing the potential for identifying these mechanisms in the observational record. A circumpolar multiannual cycle increase is found but signals also demonstrate a complex westward propagation pattern with periods of intense wave variability. Significant correlations between wavelet power at all time scales and albedo, snow cover, atmospheric ozone levels, and surface air temperature are demonstrated.
Modeling the storm time behavior of the magnetosonic waves using solar wind parameters
Authors: Kim Kyung‐Chan , Chen Lunjin
Published: December 2015

We build empirical models of magnetosonic waves (also called as equatorial noise) both outside and inside the plasmapause, based on the Time History of Events and Macroscale Interactions during Substorms fast‐survey data during the period from 1 May 2010 to 30 November 2014, which utilize solar wind measurements as model inputs, i.e., interplanetary magnetic field (IMF) Bz, solar wind speed (VSW), and dynamic pressure (PSW). For model development, the time delay of magnetosonic wave amplitude relative to the solar wind parameters is first identified based on correlation analysis. We find that PSW is better correlated with the variation of wave amplitude outside the plasmapause than VSW, while the opposite is true inside the plasmapause. Among the solar wind parameters, the preceding southward IMF Bz with the time delay of 3–4 h and 4–5 h, corresponding to outside and inside the plasmapause, respectively, yields the best correlation with the variation of wave amplitude. In this study, we use the solar wind parameter‐based model to investigate magnetosonic wave activity during corotating interaction region‐driven storm. The results show that with increasing southward IMF Bz, wave activity is amplified mostly on the dayside both outside and inside the plasmapause and high amplitude is more shifted toward the prenoon sector, while increasing PSW, it is amplified only in the postnoon sector outside the plasmapause. Our statistical model can explain the observed amplitudes by 38% on average outside the plasmapause and 26% inside, and their model performance is generally higher than that of a model using AE index only as an input.
Effects of submesoscale turbulence on ocean tracers
Authors: Smith Katherine M. , Hamlington Peter E. , Fox‐Kemper Baylor
Published: December 2015

Ocean tracers such as carbon dioxide, nutrients, plankton, and oil advect, diffuse, and react primarily in the oceanic mixed layer where air‐sea gas exchange occurs and light is plentiful for photosynthesis. There can be substantial heterogeneity in the spatial distributions of these tracers due to turbulent stirring, particularly in the submesoscale range where partly geostrophic fronts and eddies and small‐scale three‐dimensional turbulence are simultaneously active. In this study, a large eddy simulation spanning horizontal scales from 20 km down to 5 m is used to examine the effects of multiscale turbulent mixing on nonreactive passive ocean tracers from interior and sea‐surface sources. The simulation includes the effects of both wave‐driven Langmuir turbulence and submesoscale eddies, and tracers with different initial and boundary conditions are examined in order to understand the respective impacts of small‐scale and submesoscale motions on tracer transport. Tracer properties are characterized using spatial fields and statistics, multiscale fluxes, and spectra, and the results detail how tracer mixing depends on air‐sea tracer flux rate, tracer release depth, and flow regime. Although vertical fluxes of buoyancy by submesoscale eddies compete with mixing by Langmuir turbulence, vertical fluxes of tracers are often dominated by Langmuir turbulence, particularly for tracers that are released near the mixed‐layer base or that dissolve rapidly through the surface, even in regions with pronounced submesoscale activity. Early in the evolution of some tracers, negative eddy diffusivities occur co‐located with regions of negative potential vorticity, suggesting that symmetric instabilities or other submesoscale phenomenon may act to oppose turbulent mixing.
Dynamics of an idealized Beaufort Gyre: 1. The effect of a small beta and lack of western boundaries
Authors: Yang Jiayan , Proshutinsky Andrey , Lin Xiaopei
Published: December 2015

The Beaufort Gyre in the Arctic Ocean differs from a typical moderate‐latitude gyre in some major aspects of its dynamics. First, it is located in a basin without a western boundary, which is essential for closing midlatitude circulations. Second, the gradient in Coriolis parameter, β, is small and so the validity of the Sverdrup balance is uncertain. In this paper, we use an idealized two‐layer model to examine several processes that are related to these two issues. In a circular basin with closed geostrophic contours in interior, the variability of vorticity in the upper layer is dominated by eddies. But in the time‐mean circulation, the main dynamical balance in the basin's interior is between the curl of wind stress and the eddy vorticity fluxes. The torque of friction becomes important along the boundary where the rim current is strong. It is found that the smallness of β has only a relatively small impact in a circular basin without a meridional boundary. The gyre is considerably more sensitive to the existence of a meridional boundary. The time‐mean circulation weakens considerably when a peninsula is inserted between the model's center and the rim. (One side of the peninsula is dynamically equivalent to a midlatitude western boundary.) The gyre's sensitivity to β has also increased significantly when a meridional boundary is present. Subsurface ridges have similar effects on the gyre as a boundary, indicating that such topographic features may substitute, to some extents, the dynamical role of a western boundary.
The effect of lake browning and respiration mode on the burial and fate of carbon and mercury in the sediment of two boreal lakes
Authors: Isidorova Anastasija , Bravo Andrea G. , Riise Gunnhild , Bouchet Sylvain , Björn Erik , Sobek Sebastian
Published: December 2015

In many northern temperate regions, the water color of lakes has increased over the past decades (“lake browning”), probably caused by an increased export of dissolved organic matter from soils. We investigated if the increase in water color in two lakes in Norway has resulted in increased burial of organic carbon (OC) and mercury (Hg) in the sediments and if the Hg was prone to methylation. Lake Solbergvann experienced a threefold water color increase, and OC burial increased approximately twofold concomitant to the water color increase. This lake had prolonged periods of anoxic bottom water, and anoxic OC mineralization rates were only about half of the oxic OC mineralization rates (7.7 and 17.5 g C m−2 yr−1, respectively), contributing to an efficient OC burial. In Lake Elvåga, where water color increase was only approximately twofold and bottom water was oxygenated, no recent increase in OC burial could be observed. Hg burial increased strongly in both lakes (threefold and 1.6‐fold in Lake Solbergvann and Lake Elvåga, respectively), again concomitant to the recent water color increase. The proportion of methylated Hg (MeHg) in surficial sediment was 1 order of magnitude higher in Lake Elvåga (up to 6% MeHg) than in Lake Solbergvann (0.2–0.6% MeHg), probably related to the different oxygenation regimes. We conclude that lake browning can result in increased OC and Hg burial in lake sediments, but the extent of browning and the dominating mode of sediment respiration (aerobic or anaerobic) strongly affect burial and fate of OC and Hg in sediments.
Nitrogen restrictions buffer modeled interactions of water with the carbon cycle
Authors: Huang Yuanyuan , Gerber Stefan
Published: December 2015

Terrestrial carbon and water cycles are coupled at multiple spatiotemporal scales and are crucial to carbon sequestration. Water related climate extremes, such as drought and intense precipitation, can substantially affect the carbon cycle. Meanwhile, nitrogen is a limiting resource to plant and has therefore the potential to alter the coupling of water and carbon cycles on land. Here we assess the effect of nitrogen limitation on the response of the terrestrial carbon cycle to moisture anomalies using Geophysical Fluid Dynamics Laboratory's land surface model LM3V‐N. We analyzed the response of three central carbon fluxes: net primary productivity (NPP), heterotrophic respiration (Rh), and net ecosystem productivity (NEP, the difference between NPP and Rh) and how these fluxes were altered under anomalies of the standardized precipitation and evapotranspiration index (SPEI). We found that globally, the correlations between each of the carbon flux and SPEI depended on the timescale and a strong legacy effect of SPEI anomalies on Rh. Consideration of nitrogen constraints reduced anomalies in carbon fluxes in response to extreme dry/wet events. This nitrogen‐induced buffer constrained the growth of plants under wet extremes and allowed for enhanced growth during droughts. Extra gain of soil moisture from the downregulation of canopy transpiration by nitrogen limitation and shifts in the relative importance of water and nitrogen limitation during dry/wet extreme events are possible mechanisms contributing to the buffering of modeled NPP and NEP. Responses of Rh to moisture anomalies were much weaker compared to NPP, and N buffering effects were less evident.
LC/MSversus Immune‐Based Bioanalytical Methods in Quantitation of Therapeutic Biologics in Biological Matrices
Authors: An Bo , Zhang Ming , Qu Jun
Published: December 2015

This chapter reviews the main characteristics of liquid chromatography/mass spectrometry (LC/MS) and ligand‐binding assay (LBA) methods. If an LBA method for biotherapeutics quantification is well established, it usually provides sufficient sensitivity and selectivity and is considered the method of choice. The LC/MS method emerged as an alternative strategy for quantification of proteins of interest in complex biological matrices. Multiplexed capacity and selectivity are critical features determining the applicability of a bioanalytical method. Well‐established LBA methods usually provide adequate sensitivity for quantification analysis of biotherapeutics in preclinical/clinical pharmacokinetic (PK)/pharmacodynamic (PD) study. LC/MS with high resolution analyzer has become a promising technology for characterization of antibody‐drug conjugate (ADC) in the recent years. An affinity capture capillary LC coupled to quadrupole‐time‐of‐flight (TOF) MS has been employed to analyze anti‐MUC16 TDC, which obtained bothin vitroandin vivodrug‐to‐antibody ratios (DARs) information.