bluuebunny/crossref_metadata_2025 huggingface dataset:
Zero-Shot Building Age Classification from Facade Image Using GPT-4
Authors: Zeng Zichao , Goo June Moh , Wang Xinglei , Chi Bin , Wang Meihui , Boehm Jan
Published: June 2024

Abstract. A building’s age of construction is crucial for supporting many geospatial applications. Much current research focuses on estimating building age from facade images using deep learning. However, building an accurate deep learning model requires a considerable amount of labelled training data, and the trained models often have geographical constraints. Recently, large pre-trained vision language models (VLMs) such as GPT-4 Vision, which demonstrate significant generalisation capabilities, have emerged as potential training-free tools for dealing with specific vision tasks, but their applicability and reliability for building information remain unexplored. In this study, a zero-shot building age classifier for facade images is developed using prompts that include logical instructions. Taking London as a test case, we introduce a new dataset, FI-London, comprising facade images and building age epochs. Although the training-free classifier achieved a modest accuracy of 39.69%, the mean absolute error of 0.85 decades indicates that the model can predict building age epochs successfully albeit with a small bias. The ensuing discussion reveals that the classifier struggles to predict the age of very old buildings and is challenged by fine-grained predictions within 2 decades. Overall, the classifier utilising GPT-4 Vision is capable of predicting the rough age epoch of a building from a single facade image without any training. The code and dataset are available at https://zichaozeng.github.io/ba_classifier.
Brief communication: SWM – stochastic weather model for precipitation-related hazard assessments using ERA5-Land data
Authors: Whitehead Melody Gwyneth , Bebbington Mark Stephen
Published: June 2024

Abstract. Long-term multi-hazard and risk assessments are produced by combining many hazard-model simulations, each using a slightly different set of inputs to cover the uncertainty space. While most input parameters for these models are relatively well constrained, atmospheric parameters remain problematic unless working on very short timescales (hours to days). Precipitation is a key trigger for many natural hazards including floods, landslides, and lahars. This work presents a stochastic weather model that takes openly available ERA5-Land data and produces long-term, spatially varying precipitation data that mimic the statistical dimensions of real data. This allows precipitation to be robustly included in hazard-model simulations. A working example is provided using 1981–2020 ERA5-Land data for the Rangitāiki–Tarawera catchment, Te Moana-a-Toi / Bay of Plenty, New Zealand.
Alkol Kullanım Bozukluğunda Biyobelirteçler
Authors: Tekkeşin Nilgün
Published: June 2024

Son yıllarda, ağır alkol kullanımının biyolojik olarak değerlendirilmesinde önemli ilerlemeler kaydedilmiştir. Bu ilerlemeler, yeni laboratuvar testlerinin geliştirilmesini, sonuçları birden fazla ölçüm üzerinde birleştirmek için algoritmaların formüle edilmesini ve alkol kullanım bozukluğu tedavisi ve araştırmasında biyobelirteçlerin daha kapsamlı uygulamalarını içermektedir. Alkol alımı, muhtemelen dünya çapındaki en eski sosyal alışkanlıktır, birçok kültürde oldukça yaygındır ve sağlık ve sosyal sorunların küresel yüküne önemli ölçüde katkıda bulunur. Alkol kullanım bozukluğu tespitine yönelik biyobelirteçler hakkında yayınlanan çok sayıda çalışmalar bilimsel platformlarda yer almasına rağmen, halen birkaç temel soru devam etmektedir. Herşeyden önce, doz-yanıt ilişkilerinin belirtilmesi gerekir. Alkol sorunlarının taranmasında, belirli bir biyobelirteç kullanılmadan önce belirli bir “şüphe sorgulaması” olabilir. Bu şüphe sorgulaması, kişinin yetersiz bir öz bildirimi veya klinik muayenede belirsiz bulgular içerir. Biyobelirteçler, geçerlilik ve güvenilirlikle ilgili olağan psikometrik konuların çoğuna tabi olsa da, değerlendirmeleriyle ilgili hususlar farklıdır. Bunun yerine, biyobelirteçlerin değerlendirilmesindeki başlıca kriterler; ölçüt geçerliliği, kararlılık, test-tekrar tutarlılığı ve klinik yorumlamada güvenilirlik ile ilgilidir. Bu performans bilgileri, özellikle tam otomatik test prosedürlerinin geliştirildiği CDT (Carbonhydrate Deficient Transferrin) gibi yeni belirteçler için de geçerli durumdadır. Biyobelirteçlerin kullanımı ile klinik karar vermedeki çözümsel yaklaşım daha netlik kazanmaktadır. Bu nedenle biyobelirteçlerin artan bilgi değerini ölçmek ve beraberinde etkili algoritmaların araştırılması kritik öneme sahiptir. Bu makalemiz özellikle tanısal-tarama testi olarak kullanılan biyobelirteçlerle ilgili genel konuları ele almaktadır.
The Writer’s Desk: place, subject, object
Authors: Haddad George
Published: June 2024

This creative writing research experiments with and examines perception, orientation, and queer phenomenology to suggest that the writer’s place (my desk) is not instrumental to my creative output. The creative component encompasses three brief writing experiments to produce data that is then analysed through theoretical frameworks in order to make the conclusion on my experience of the writer’s place.
Windows in the writing centre: students’ physical orientation toward or away from natural light is determined by genre
Authors: Cairney Anna
Published: June 2024

Drawing from an ethnographic study, this project reveals a relationship between genre and the role of natural light in a writing centre. Using observation, interviews, and analysis, the author discovers that students prefer to face natural light during formative writing and sit with their backs to natural light during summative writing or while leading a writing consultation. This revelation about the role of light with respect to the type of writing presents questions about writing centre design and the implications of space created for creative and intellectual pursuits.
The Strange Relation of Poetry to Place
Authors: Magee Paul
Published: June 2024

The article analyses my interviews with a number of poets whose works seem to subvert space in various ways. I report my surprise in discovering, within those interviews, a tendency for the poets nonetheless to describe themselves and even their actual poems in national terms. C.D. Wright, for instance, referred in her interview to her having “an American ear,” in spite of her work’s seeming deconstruction of any such broad identities. This leads me to a discussion of the interpellative devices of the nation-state that serve to draw poets into ascribing a national identity to themselves and their work in a range of forums, up to and including the international research interview. But even granting the pervasive ideological mechanisms of the nation-state, it seems clear that the poets interviewed are genuinely reporting back on their experience of compositional work and its drivers, when according a role to the nation and/or geographic space they inhabit. The paper draws on developments in contemporary linguistics to suggest that what they are in fact naming is a localised idiom. It is that which serves to launch them into the kinds of spaces Emily Dickinson evoked, when avowing “I dwell in possibility / a fairer house than prose.” That fairer house – poetic possibility itself – is rooted in idiom.
Determinants of Green Purchase Behavior: An Implication of Theory of Reasoned Action
Authors: Liaquat Malka , Iqbal Iram , Munir Sana , Waheed Noorulain
Published: June 2024

This research aims to understand the factors that influence consumer green purchasing behavior. A theoretical model of TRA and TPB has been applied to study consumer behavior. For analyzing the model 540 middle income-earners of Multan are selected with a non-probability conviction sampling technique has been used. The data has been analyzed using the PLS-SEM technique. The results obtained show a positive association between Intention-Behavior, Attitude-Intention-Behavior, Subjective Norms-Intention-Behavior, Consumer Perceived Environmental Concern-Intention-Behavior, and Green Product Knowledge-Intention-Behavior. This study enhances the understanding of consumer behavior in the Southern belt of Pakistan by adding more insight into the literature on TRA and TPB.  The unique concept of this study is the Green Product Knowledge that has been widely used in marketing research but still fewer studies have focused on the impact of GPK.
Genomic Insights into SARS-CoV-2 Evolution: Nucleocapsid Gene Mutations in West Sumatra, Indonesia
Authors: Linosef Linosefa , Hasmiwati Hasmiwati , Jamsari Jamsari
Published: June 2024

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has necessitated a comprehensive understanding of viral mutations, particularly in the nucleocapsid protein, which plays a crucial role in the virus's life cycle and interaction with the host immune system. This study aims to analyze the nucleocapsid (N) gene mutations in SARS-CoV-2 variants isolated from West Sumatra during the pandemic. A dataset of 352 SARS-CoV-2 sequences from local COVID-19 cases was examined to identify N gene mutations and assess their prevalence across different variants. The primary mutations identified were R203K and G204R in the ancestral and Omicron variants. However, the D63G and D377Y mutation is present in the Delta variant. These mutations are implicated in enhancing viral infectivity and potential immune evasion. Notably, the Omicron variant showed additional deletions and mutations (P13L, E31-, R32-, S33-, and S413R) that harm protein expansion for structural stability and functionality of the nucleocapsid protein. The conservation of specific mutations across variants suggests their fundamental role in viral replication and immune interaction. Variant-specific mutations may represent adaptive responses to immune pressure or other environmental factors, with significant implications for viral transmissibility and pathogenicity. Understanding the impact of nucleocapsid protein mutations provides critical insights into the evolutionary dynamics of SARS-CoV-2 and aids in developing effective vaccines and therapeutics. Continued surveillance and detailed functional studies are essential to manage the pandemic and prepare for future viral outbreaks.

Keywords: SARS-CoV-2, nucleocapsid protein, N gene, mutations, viral evolution.
Media Pembelajaran Maths Multiplication Calculator dalam Membantu Masalah Pembelajaran Perkalian di Sekolah Dasar
Authors: Shafitri Alviani Nurlaelli , Ginanjar Ani Yanti , Damayanti Alivia , Fatharani Delpi Fajira , Muhamad Nurdin
Published: June 2024

Penelitian ini melibatkan penggunaan media pembelajaran Maths Multiplication Calculator untuk membantu siswa SD memahami perkalian dari 6 hingga 18. Dua kelompok siswa terlibat, satu menggunakan kalkulator, sementara kelompok lain menerapkan metode konvensional. Hasilnya menunjukkan peningkatan pemahaman yang signifikan pada kelompok yang menggunakan kalkulator, terutama pada rentang perkalian yang ditetapkan. Pemanfaatan media pembelajaran maths multiplication calculator ini tidak hanya meningkatkan efektivitas pembelajaran, tetapi juga menciptakan suasana belajar yang lebih interaktif dan menyenangkan bagi peserta didik. Penelitian ini memberikan kontribusi penting untuk memahami bagaimana penggunaan kalkulator matematika dapat meningkatkan pemahaman konsep matematika di SD, menekankan pentingnya teknologi dalam pembelajaran. Kata Kunci: kalkulator matematika, pembelajaran interaktif, pemahaman siswa, perkalian, SD.
Présence de Scirpoides holoschoenus (L.) Soják en Haute-Loire, en dehors du domaine méditerranéen
Authors: Pépin Florine , Hugonnot Vincent
Published: June 2024

Scirpoides holoschoenus (L.) Soják est une espèce abondante et largement répandue dans la région méditerranéenne, mais qui reste exceptionnelle en Auvergne, où aucune observation n’avait été rapportée depuis plus de 50 ans. Une population isolée a été découverte dans la haute vallée de l’Allier, Haute-Loire, sur les berges d’alluvions fluviatiles. Le contexte stationnel est brièvement décrit. Cette population est apparemment installée depuis de nombreuses années, mais semble actuellement incapable de s’étendre autrement que par expansion végétative. À l’avenir, avec l’augmentation des températures moyennes due au changement climatique, cette espèce pourrait être en mesure de produire des semences viables, et alors commencer à former de véritables populations fertiles hors du domaine méditerranéen.
Découverte de Narcissus assoanus Dufour dans le nord du Massif central et dans la région Auvergne
Authors:   UniVegE - Herbiers CLF, Université Clermont Auvergne, Voisin Antonin
Published: June 2024

Narcissus assoanus Dufour a été observée pour la première fois sur le Puy de Crouel (Puy-de-Dôme). Cette note discute de l’identification, de l’écologie et de la répartition de cette espèce d’affinité méditerranéenne. L’origine de cette nouvelle station est discutée brièvement.
О СУЩНОСТИ ПОНЯТИЯ ЦИФРОВОЙ ТРАНСФОРМАЦИИ В РАЗВИТИИ СОЦИАЛЬНО-ЭКОНОМИЧЕСКИХ СИСТЕМ
Authors: Абдыкадыров Санжар , Илимбеков Медетбек , Эрмекбаева Айжана
Published: June 2024

В рамках данной статьи были рассмотрены ключевые аспекты воздействия цифровой трансформации на современное общество, включая изменения в социальных отношениях, экономике, инновациях и устойчивом развитии. Цель исследования заключается в выявлении потенциала цифровых технологий для улучшения качества жизни граждан, стимулирования экономического роста и содействия устойчивому развитию общества. Полученные результаты могут быть полезны как для научного сообщества, так и для практических решений в различных областях деятельности. Далее предложены рекомендации для Кабинета Министров Кыргызской Республики.
АВТОТРАНСПОРТТУК КОМПАНИЯЛАРЫНЫН ИНВЕСТИЦИЯЛЫК МҮМКҮНЧҮЛҮКТӨРҮНҮН ӨЗГӨЧӨЛҮКТӨРҮ
Authors: Мырзаибраимова Инабаркан , Ганиев Гайратбек
Published: June 2024

Бул макалада Кыргызстандын экономикалык абалын көрсөтүп турган автомобиль транспорттук компаниялары үчүн инвестициялык ишкердүүлүктүн  инвестициялык мүмкүнчүлүктөрдү байкоо  жолдору, алардын узак мөөнөттүү ийгилигин жана туруктуу өнүгүүсүн камсыз кылуудагы финансылык  негиздерин тартуу каралат. ранспорт системасы аймактардын экономикалык жана өнөр жайлык өнүгүүсүнүн негизи болуп саналат. Автомобиль транспорттук компанияларынын  экономиканы гана эмес, ошондой эле калктын социалдык чөйрөсүн аймактык өнүктүрүүнүн мүмкүнчүлүктөрү жана алардын жашоо сапаты транспорттук кызмат көрсөтүүлөрдүн жеткиликтүүлүгүнө жана жеткиликтүүлүгүнө жараша болот. Транспорт комплексинин экономика үчүн ролу ачык жана аны экономиканын бардык тармактарын өнүктүрүүгө көмөктөшүүгө тийиш болгон инфраструктуралык көз караштан гана эмес, ошондой эле экономиканын өз алдынча сектору, өнүктүрүү динамикасы дүң кошумча нарктын, негизги каражаттардын жана инвестициялардын наркынын көрсөткүчтөрү аркылуу мүнөздөлүшү мүмкүн.
АНАЛИЗ СТРУКТУРЫ И ДИНАМИКИ МАТЕРИАЛЬНЫХ ЗАПАСОВ ПРЕДПРИЯТИЯ И ПРАКТИКА ЕГО ПРИМЕНЕНИЯ
Authors: Култаева Насима , Зайирова Венера , Бекмуратов Алтынбек
Published: June 2024

Анализ использования материальных запасов является важнейшим направлением деятельности предприятия. Данная статья посвящена вопросам анализа структуры и динамики материальных запасов предприятия, а также повышения эффективности их использования. Апробирована методика анализа структуры и динамики запасов на примере одного из производственных предприятий. Даны рекомендации по повышению эффективности использования материальных запасов.
ЭНЕРГЕТИКАЛЫК КОМПАНИЯЛАРДЫН БАШКАРУУ ЭСЕБИН УЮШТУРУУНУН КӨЙГӨЙЛӨРҮ
Authors: Исраилов Тимур , Жанибек уулу Тагайбек , Ильясова Элиза
Published: June 2024

Бул статьяда энергетикалык компаниялардын башкаруу эсебин уюштуруунун  негизги өзгөчөлүктөрү карлаган. Башкаруу эсептин негизги түшүнүгү, максаты, милдеттери, функциялары, автордук түшүнүк кеңири изилденген. Мындан сырткары, электроэнергияны өндүрүүдөгү чыгымдарды эсепке алуунун методдору, аларды колдонуу чөйрөсү, көйгөйлөрү жана аларды чечүү жолдору каралган. Калькуляция методдорунун  колдонулушунун артыкчылыктары жана кемчилдиктери изилденген жана практикалык көрсөтмөлөр менен рекомендациялар иштелип чыгып, сунушталган.
КРИЗИСТИН ЖОГОРУЛАШЫ ШАРТЫНДА ЧАРБА СУБЪЕКТИЛЕРИНИН КАРЖЫ АБАЛЫН ТАЛДООДОГУ ТЕОРИЯЛЫК АСПЕКТИЛЕР
Authors: Кулуева Чинара , Орозов Толкунбек , Курманкулова Айжан , Сатыбалдиева Акселки
Published: June 2024

Ишкананы, банкты жана башка чарба жүргүзүүчү субъекттерди башкарууда каржылык талдоонун зарылчылыгы жөнүндө корутундулар иштелип чыкты. Тобокелдиктер жогорулаган шарттарда каржы туруктуулугуна жетишүүдө каржылык абалдын орду аныкталган. Финансылык талдоо ыкмаларын колдонуунун максатка ылайыктуулугу экономиканы өнүктүрүү жана узак мөөнөттүү мезгилге анын каржы-чарбалык ишинин натыйжалуулугун жогорулатуу максатында зарыл каржы  ресурстар менен камсыз кылуу негизделген. Финансылык талдоо ишкананын финансылык туруктуулугунун деңгээлин аныктоо үчүн финансылык маалыматты аныктоого, тутумдаштырууга жана аналитикалык иштетүүнү жүргүзүүгө мүмкүндүк берери аныкталган.
Transcanal Endoscopic Management of Attic Cholesteatoma: Surgical Steps from a Case Report
Authors:   Praticien Hospitalier, ENT Surgeon, Groupe Hospitalier La Rochelle, France., Di Laora Andrea
Published: June 2024

This case report describes the case of a patient affected by an attic cholesteatoma treated by a totally transcanal endoscopic approach. Each surgical step of this minimally invasive technique is explained. The functional and anatomical results during follow-up are described.
Breast-Conserving Therapy and Irradiation in Women with Prior Breast Augmentation
Authors:   Department of Plastic Surgery, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark., Ditlev Martine , Matthiessen Louise Wichmann ,   Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark., Engelböl Friis Camilla ,   Department of Breast Surgery, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark., Hölmich Lisbet Rosenkrantz ,   Department of Plastic Surgery, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.
Published: June 2024

Introduction: The incidence of breast-augmented women developing breast cancer is increasing and there is some disagreement regarding the optimal cancer treatment, in the setting of prior breast augmentation. The purpose of this study was to describe the outcome of Breast-conserving surgery and Radiation Treatment (BCT) for breast cancer, with preservation of the breast implants in breast-augmented women. Methods: Medical records of 30 women with prior breast augmentation, undergoing BCT at our institution between 2018 and 2021, were retrospectively reviewed. Data regarding complications, capsular contracture rates, oncological and overall cosmetic outcomes following treatment were registered. Results: Median follow-up time was 29 months with an overall complication rate of 30%. Surgeryrequiring complications (capsular contracture) were observed in 10% of the patients, one case resulting in implant removal and two cases resulting in implant exchange, whereas 20% had complications not requiring reoperation. Two patients (7%) had positive margins and underwent re-excision. No patients experienced cancer recurrence. Fifty percent of those with relevant information (n=3/6) developed or had worsening of capsular contracture, and 63% (n=7/11) were evaluated as having an excellent to good overall cosmetic appearance upon follow-up.
Advancements in the Treatment of Recurrent Metastatic Colorectal Cancer
Authors:   Department of General Surgery, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, P.R. China., Fan Jiawen , Yang Dinghua ,   Department of General Surgery, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, P.R. China.
Published: June 2024

Radical resection is the main approach for achieving a cure in patients with recurrent liver metastasis of colorectal cancer. However, due to the limited liver volume and the tolerance of late-stage tumor patients, it is not possible to perform repeated resections infinitely. Therefore, the scope and timing of repetitive liver resection become critically important. In the opposing contradiction between the residual liver volume (FLR) and tumor burden, finding the most beneficial treatment plan for patients is the mission of precision medicine. The treatment of colorectal cancer liver metastasis emphasizes a Multidisciplinary Team (MDT) approach, aiming to achieve disease-free survival or prolong the patient’s survival.
Isolated Breast Sarcoidosis
Authors:   Department of Radiology, Rio de Janeiro State University, Boulevard 28 de Setembro, 77, Vila Isabel, Rio de Janeiro, RJ, Brazil., de Mattos Thamires Coutinho Marques , Sirimarco Felipe Miguel Holanda Cavalcanti ,   Department of Radiology, Rio de Janeiro State University, Boulevard 28 de Setembro, 77, Vila Isabel, Rio de Janeiro, RJ, Brazil., Bonotto Paula Medina Maciel Gomes Curi ,   Department of Radiology, Rio de Janeiro State University, Boulevard 28 de Setembro, 77, Vila Isabel, Rio de Janeiro, RJ, Brazil.
Published: June 2024

Background: Sarcoidosis is a rare non-caseating granulomatous disease of unknown origin that affects multiple systems in the body occurring more frequently in young women age 17-24 years. Cases with manifestations that doesn’t affect the common organs can be difficult to identify and delay the patient’s diagnosis, meaning that the finding of an isolated breast mass should include sarcoidosis as one of its differentials, to ensure early detection and a better prognosis. Case presentation: We present the case report of a 21-year-old female patient, who had noticed a palpable breast nodule associated with local pain and fever for 2 months. Physical examination detected palpable bilateral axillary lymph nodes, a nodule occupying the lateral quadrants of the left breast and bullous lesions, along with phlogistic signs in the same topography. The imaging exams of the chest, showed a solid-cystic complex in the lateral quadrants of the left breast, in addition to bilateral axillary lymph node enlargement. Laboratory tests was unremarkable. The histopathological tests detected fibroadipose tissue with noncaseating granulomas, neutrophilic microabscesses and Langerhans-type giant cells, causing chronic granulomatous mastitis, which may represent sarcoidosis. The lesions regresed after the use of corticosteroids. Conclusion: Despite its rarity, the clinical and imaging findings such as those of this patient, should warrant the consideration of breast sarcoidosis as a possible diagnosis given the importance of excluding similar conditions, such as neoplasms, early on.
Computer-Aided Diagnosis System Based on Deep Learning for Diagnosis of Atypical Endometrial Hyperplasia and Endometrial Cancer on Hysteroscopy
Authors:   Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Wang Wenwen , Guo Zhe ,   Graduate School of Computer Science and Engineering, The University of Aizu, Aizu-Wakamatsu, Japan., Zhao Aihua ,   Graduate School of Computer Science and Engineering, The University of Aizu, Aizu-Wakamatsu, Japan., Ma Wenqing ,   Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Wang Yan ,   Department of Gynecology, Maternal and Child Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Du Xin ,   Department of Gynecology, Maternal and Child Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Wang Wuliang ,   Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China., Zhu Xin ,   Graduate School of Computer Science and Engineering, The University of Aizu, Aizu-Wakamatsu, Japan., Wang Shixuan ,   Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Published: June 2024

Hysteroscopy is an effective tool to diagnose and treat abnormal uterine bleeding or uterine cavity abnormalities, especially precancerous or cancerous disorders. In this study, we proposed an Endometrial Cancer (EC) Computer-Aided Diagnosis System (ECCADx) based on deep learning to boost the diagnostic accuracy for recognizing Atypical Endometrial Hyperplasia (AEH) and EC. ECCADx was developed using a training dataset with 49,646 images from 1,237 patients in Maternal and Child Hospital of Hubei Province (MCH) and two test datasets with 7,243 images from 209 patients in MCH, Tongji Hospital (TJH), and The Second Affiliated Hospital of Zhengzhou University (ZZSH). We compared the diagnostic efficiency between the proposed system and eight gynecological endoscopists from two different hospitals (MCH and TJH) using a hospital cross-testing method. The sensitivity, specificity and AUC of ECCADx were 92.8% (95% CI 85.7-100%), 92.5% (95% CI 86.7-98.3%), and 0.965 (95% CI 0. 931-1) on MCH test dataset (internal data), respectively, superior to two gynecological endoscopists and having no significant difference compared with the other two endoscopists at TJH. For TJH/ZZSH test dataset (external data), the sensitivity, specificity and AUC were 75.2% (95% CI 59.5-90.8%), 95.2% (95% CI 91.5-99.0%), and 0.881 (95% CI 0.789-0.967), respectively, superior to three gynecological endoscopists and having no significant difference compared with the other endoscopist at MCH. ECCADx demonstrated excellent performance in identifying AEH and EC in test datasets from different medical centers. The effectiveness of ECCADx was comparable or even better than those of experienced gynecological endoscopists.
Evaluation of the Antimicrobial and Antioxidant Activity of the Pulp of Artocarpus heterophyllus Lam (Moraceae)
Authors:   Department of Pharmaceutical/Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Nigeria., Ajinwo Johnson , Rosa Okiemute ,   Department of Pharmaceutical/Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Nigeria., Worika Paul ,   Department of Pharmaceutical/Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Nigeria., Nengi Priscilla ,   Department of Pharmaceutical/Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Nigeria.
Published: June 2024

Artocarpus heterophyllus Lam. (Moraceae) - Jackfruit beyond its culinary uses has been used to treat ailments ethnomedicinally. Its bark, leaves, seeds, and pulp are rich sources of bioactive compounds. This research aims to evaluate the antimicrobial and antioxidant activity of the pulp of the fruit; to identify the bioactive compounds present, that contributes these activities. The pulverised dried pulp was extracted using dichloromethane and methanol (1:1) and partitioned into respective fractions using n-hexane and methanol. Proximate analysis and Phytochemical screening were carried out using standard methods. Gas Chromatography - Mass Spectrometry (GC-MS) and Fourier Transform Infrared Spectroscopy (FTIR) were used for chemical profiling and detection of functional groups respectively. Antimicrobial activity testing was carried out, using the agar well diffusion assay. Antioxidant activity was evaluated using DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. Proximate analysis showed the presence of moisture (16.96%), fibre (20.89%), carbohydrate (50.63%), protein (7.20%), ash (2.26%), and lipid (2.06%). The phytochemical screening revealed the presence of alkaloids, flavonoids, phenolics, saponins, carbohydrates, proteins, tannins, steroids/triterpenoids and phlobatannins. Ten compounds were identified from the GC-MS Analysis. The pharmacologically active compounds were 9,12-octadecadienoic acid methyl ester, 9,12,15-octadecatrienoic acid methyl ester, 1-docosene, and lycopersene. FTIR analysis revealed the presence of aliphatic hydrocarbons (alkane, alkene) and oxygenated functional groups (hydroxyl, esters, aldehydes, ketones, ethers). The methanol, n-hexane fractions and total extract exhibited antimicrobial activity against Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. Regarding antioxidant activity, the methanol, n-hexane fractions and total extract showed IC50 values of 39.191 µg/ml, 102.5 µg/ml and 70.10 µg/ml respectively. The results of this study demonstrates that Artocarpus heterophyllus Lam. possesses significant antimicrobial and antioxidant properties due to the presence of bioactive compounds and holds promising implications for pharmaceutical applications.
Patterns and Determinants of Undernutrition in Pre-School Age Children in the North West Region of Cameroon
Authors:   Department of Clinical Sciences, Faculty of Health Sciences, University of Bamenda, Cameroon., Chiabi Andreas , Ngum Rosine ,   Department of Clinical Sciences, Faculty of Health Sciences, University of Bamenda, Cameroon., Niba Loveline Lum ,   Department of Public Health, Faculty of Health Sciences, University of Bamenda, Cameroon., Mambap Alex Tatang ,   Department of Clinical Sciences, Faculty of Health Sciences, University of Bamenda, Cameroon., Angwafor Samuel ,   Department of Clinical Sciences, Faculty of Health Sciences, University of Bamenda, Cameroon., Ashuntantang Gloria ,   Department of Clinical Sciences, Faculty of Health Sciences, University of Bamenda, Cameroon.
Published: June 2024

Background and aim: Malnutrition is a major public health concern for children under five years. About 45% of deaths among children under five years globally are linked to undernutrition. The aim of the study was to to evaluate the patterns and determinants of undernutrition in pre-school age children in four Subdivisions in Mezam division of the North west region.
Pediatric Atelectasis: Insights from Diagnostic Imaging
Authors:   Family Medicine Department, Arroyomolinos Community Health Centre, Arroyomolinos, Spain., Tenajas Rebeca , Miraut David ,   Advanced Healthcare Technologies Department, GMV Innovating Solutions, Spain.
Published: June 2024

This article presents a detailed case study of a 10-year-old child, born in 2013, exhibiting symptoms of a febrile syndrome and subsequent diagnostic findings suggestive of atelectasis through chest radiography and Computed Tomography (CT) scans without intravenous contrast. Atelectasis, a condition characterized by the collapse of lung tissue, represents a significant diagnostic challenge in pediatric patients. This study delves into the radiographic and CT findings, emphasizing the importance of imaging in diagnosing and managing atelectasis.
New Cardiovascular Event One Year Later in Patient with Good Control of Cardiovascular Risk Factor
Authors:   Department of Systems Medicine, University Tor Vergata, 00133 Rome, Italy., Giamundo Domenico Mario
Published: June 2024

Secondary prevention after SCA (Acute Coronary Syndrome) is of paramount importance to reduce the incidence of MACE and improve prognosis in follow-up.
A Cross–Sectional Study on HIV Positive Mothers and Infant Feeding: Paradigm of Choices in a Regional Hospital in Cameroon
Authors:   Faculty of Health Sciences, University of Bamenda, Bamenda, Cameroon., Dobgima Pisoh W
Published: June 2024

Objective: The general objective of this study was to identify the infant feeding choices of HIV-positive mothers in four hospitals in the Bamenda Health District.
Study on the Structure of Sputum Flora in Silicosis Patients with Different Stages
Authors:   Shenzhen Campus, Sun Yat-Sen University, 66 Gongchang Road, Guangming District, Shenzhen, 528406, China., Liu Tao
Published: June 2024

Silicosis is a serious respiratory disease, which causes great harm to human health. Silicosis patients due to long-term exposure to silica dust particles, may lead to the imbalance of bacterial flora in the respiratory tract, thereby increasing the risk of respiratory infection. In this study, sputum samples from inpatients with silicosis at different stages in a hospital in Chengdu were collected, the genome was extracted, the sputum sample genome was sequenced by high-throughput sequencing technology, and the microflora composition of sputum samples was obtained by using QIIME 1.8.0 for analysis, including OTUs analysis, Alpha diversity analysis, Beta diversity analysis, etc. Then, the structure of respiratory microflora in silicosis patients was analyzed, and the composition, distribution and diversity of microflora in sputum of silicosis patients with different stages were compared. The results showed that the sputum flora of silicosis patients were firmicutes, Proteobacteria, Bacteroidetes, actinobacteria and clostridium, which were consistent with those of healthy people. However, there were differences in the placement of dominant bacteria in silicosis patients with different stages. Therefore, the study of sputum flora structure of silicosis patients with different stages is helpful to further understand the pathophysiological process of silicosis, and provide a more in-depth theoretical basis for the prevention, early diagnosis and treatment of silicosis.
Opinion Understanding Epidemics - Steps Towards a Theoretical Epidemiology
Authors:   Bertalanffy Center for the Study of Systems Science, Vienna, Austria., Tretter Felix
Published: June 2024

Due to the author’s context commitment, epidemiology is understood as a central subfield of public health and medicine. It provides data and models for understanding population’s health risks and thus providing orientation and action for public health. The corona pandemic in particular has shown us many options but also needs for improvement of data-driven epidemiological modelling as it implies difficulties at interpretation compared to explanatory concept-oriented modeling. The modelling was also conceptually quite one-dimensional, using mainly medical data and largely ignoring psychosocial aspects. In addition, the fixation on quantitative observations has led to the neglect of patients’ voices and even the experiences of medical staff. As a result, and because of these shortcomings, public health regulations were likely to be suboptimal and associated with numerous adverse side effects. This has been demonstrated for some countries in Europe, especially Germany.
Knowledge, Attitudes and Practices Regarding Onchocerciasis and Community-Directed Treatment with Ivermectin: A Cross-Sectional Study in South Sudan
Authors:   Department Ophthalmology, College of Medicine, University of Juba, Juba, South Sudan., Lino Sube Kenneth Lado
Published: June 2024

Introduction: Despite decades of ivermectin mass drug administration for the control of onchocerciasis (river blindness) in South Sudan, it continues to cause significant ocular burden in endemic foci. The objective of this study was to assess the community’s Knowledge, Attitudes, and Practices (KAP) about onchocerciasis and Community Directed Treatment with Ivermectin (CDTI) in Raga and Deim Zubeir, Western Bahr el Ghazal state (South Sudan).
Valproic acid-induced acute pancreatitis: First case report in Morocco and literature review
Authors:   Anesthesia and Intensive Care Department, Mohamed V Military Training Hospital Hassan II University of Casablanca, Morocco., Salahedddine Fjouji , Anass Elbouti ,   Anesthesia and Intensive Care Department, Anesthesia and Intensive Care Department, Mohamed V University of Rabat, Morocco., Abdelhafid Houba ,   Anesthesia and Intensive Care Department, Anesthesia and Intensive Care Department, Mohamed V University of Rabat, Morocco., Nourreddine Kartit ,   Anesthesia and Intensive Care Department, Mohamed V Military Training Hospital Hassan II University of Casablanca, Morocco., Nawfal Doghmi ,   Anesthesia and Intensive Care Department, Anesthesia and Intensive Care Department, Mohamed V University of Rabat, Morocco., H Balkhi ,   Anesthesia and Intensive Care Department, Anesthesia and Intensive Care Department, Mohamed V University of Rabat, Morocco.
Published: June 2024

Acute pancreatitis is an inflammation of the pancreas following self-destruction by its own enzymes responsible for local lesions and systemic response. In rarely cases, several drugs are described as having adverse effects causing acute pancreatitis outside of a context of drug intoxication. Classically, drug-induced acute pancreatitis tends to be edematous and has a relatively limited course over time. Several cases of pancreatitis due to sodium valproate are described in the literature. We describe a first clinical case in Morocco of an epileptic adolescent treated with sodium valproate who developed severe acute pancreatitis. Making a diagnosis of drug-induced acute pancreatitis is based to evaluate intrinsec and extrinsec imputability of this drug. The mortality of valproate acid-related pancreatitis is estimated at 15%. Neurologists, pediatricians and emergency physicians must be informed of this complication.
Exploring the interaction between bile acid and intestinal microbiota in acute-on-chronic liver failure and the progress of treatment strategies
Authors:   The Third Affiliated Hospital, Jiangxi Medical College, Nanchang University, China., Zeng Yuyu , Gan Dakai ,   Infectious Diseases Hospital Affiliated to Nanchang University, China., Zeng Yuhe ,   Shanxi Medical University, China., Xiong Molong ,   The Third Affiliated Hospital, Jiangxi Medical College, Nanchang University, China.
Published: June 2024

Acute-on-Chronic Liver Failure (ACLF) is an acute and severe disease involving single or multiple organ failure. Due to the unclear pathogenesis, there is still a lack of effective drug treatment. Intestinal microbiota is closely related to Bile Acid (BA) metabolism. In the progression of chronic liver disease to ACLF, BA metabolism disorder is often accompanied by intestinal microbiota imbalance, which affect one another mutually. This article reviewed the role of BA metabolism and intestinal microbiota in the progression of ACLF, which aims to explore potential new targets for the treatment of ACLF.
Eating disorder symptoms and diagnoses in adults with celiac disease
Authors:   Department of Psychiatry, Columbia University Irving Medical Center, New York, USA., Schebendach Janet E , Lee Anne R ,   Department of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, Harkness Pavilion, New York, USA., Gholmie Yara ,   Department of Health and Behavior Studies, Program in Nutrition, Teachers College, Columbia University, New York, USA., Wolf Randi ,   Department of Health and Behavior Studies, Program in Nutrition, Teachers College, Columbia University, New York, USA., Lebwohl Benjamin ,   Department of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, Harkness Pavilion, New York, USA., Green Peter HR ,   Department of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, Harkness Pavilion, New York, USA.
Published: June 2024

Introduction: Treatment for Celiac Disease (CeD) includes strict adherence to a Gluten-Free Diet (GFD) which may result in preoccupation with food choice, unwanted weight gain, and body dissatisfaction. Objective: To determine frequency of Eating Disorder (ED) diagnoses and symptoms in adults with CeD. Method: The Eating Disorder Diagnostic Scale (EDDS-DSM-5) and the Eating Pathology Symptoms Inventory (EPSI) were administered in a cross-sectional study of 50 adults with biopsy-confirmed CeD on a GFD for >1 year attending their routine clinic visits. Results: Based on the EDDS, one participant met criteria for Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnosis of binge eating disorder and four met criteria for possible diagnosis of Other Specified Feeding and Eating Disorders; none had previously been diagnosed with an ED. EDDS symptom scores were lower (i.e., better) than established cut-points, yet females scored higher than males when asked if they felt fat (p<0.001), feared weight gain (p<0.001), and felt undue influence of weight/ shape (p=0.034). EPSI scores were lower (i.e., better) than normative values, yet females scored significantly higher than males on body dissatisfaction (p<0.001), cognitive restraint (p=0.011), and purging (p=0.044) subscales. Conclusion: Although disordered eating behaviors and weight/ shape concerns were apparent, only one patient met full criteria for an ED diagnosis. The EDDS and EPSI may be useful in screening for comorbidity among adults with CeD; however, clinical assessment is needed to assign a DSM-5 ED diagnosis.
Severe cases of SARS-CoV-2 in individuals with alcoholic liver disease and cirrhosis: Understanding the impediments to intensive care unit ventilation
Authors:   Department of Hepatology and Gastroenterology, GHPSO, Creil, France., Zougmoré Honoré Tegwendé , Renaud Estelle ,   Department of Intensive Care, GHPSO, Creil, France., Cadranel Jean François David ,   Department of Hepatology and Gastroenterology, GHPSO, Creil, France.
Published: June 2024

SARS-CoV-2, the causative agent of Severe Acute Respiratory Distress Syndrome (SARS-CoV-2), has instigated a swiftly evolving pandemic since late 2019, characterized by a mortality rate ranging from 0.5% to 3%. The deleterious impact of COVID-19 on the realm of hepatology has become evident, as chronic liver disease has escalated the risk of mortality associated with COVID-19 globally. The constraint on therapeutic interventions may have played a role in contributing to excessive mortality among individuals with pre-existing severe liver disease or alcohol use disorders. The primary aim of this editorial is to delineate the impediments to intensive care unit ventilation in patients with alcoholic liver disease and cirrhosis who are afflicted with severe SARS-CoV-2.
The management of peptic ulcer disease using conventional methods, bioactive compounds and dietotherapy: A review
Authors:   Department of Food Science and Technology, University of Nigeria Nsukka, Nigeria., Anchang Mumukom Maximus , Okoyeuzu Francis Chigozie ,   Department of Food Science and Technology, University of Nigeria Nsukka, Nigeria., Okafor Jane Ngozi ,   Department of Food Science and Technology, University of Nigeria Nsukka, Nigeria.
Published: June 2024

Purpose of review: The management of Peptic Ulcer Disease (PUD) is achieved using pharmacological agents to counteract the aggressive factors or stimulate the mucosal defence. In recent years, plant-based bioactive products have gained popularity as an alternative management protocol due to the increased antibiotic resistance of Helicobacter pylori (H. pylori), lower cost, perceived effectiveness, availability, and little side effects. In this review, we summarized the conventional treatment methods, alternative bioactive compounds, and the dietotherapy of PUD.
THE EFFECTIVENESS OF SOCIAL MEDIA PLATFORMS IN ENHANCING ORAL COMMUNICATION SKILLS
Authors:   Uzbekistan State World Languages University, Kenjayeva Diana
Published: June 2024

The article advocates for the utmost need for integrating social media applications in EFL classrooms as part of Mobile Assisted Language Learning by highlighting the benefits they holdspecifically in terms of developing speaking skills. The primary goal of the approach being discussed is not to integrate social media use into modern classrooms for the sole sake of using but instead, some of the possible, previously investigated appliances of social media platforms such as Telegram, Instagram, Facebook, and WhatsApp are specified and their role in honing speaking aspect.
EXPLORING INNOVATIVE TEACHING AND LEARNING APPROACHES IN HIGHER EDUCATION: EMPOWERING STUDENTS FOR SUCCESS
Authors:   Alisher Navo'i named after Tashkent state university of uzbek language and literature, Niyazova Gulnorakhon , Nelidova Darya ,   ELT Coordinator for Central Asia
Published: June 2024

This article explores various innovative teaching and learning approaches in higher education, including gamification, flipped learning, project-based learning, peer teaching, online and blended learning, and the use of multimedia resources. It examines how these approaches promote active engagement, critical thinking, and collaboration among students. The article emphasizes the importance of student-centered learning and the application of knowledge in real-world contexts. By incorporating these strategies, educators can create dynamic learning environments that cater to the diverse needs of students, fostering deeper understanding and essential skills for success in academia and beyond.
MAKING ASSESSMENT AND CONSTRUCTIVE FEEDBACK
Authors:   Tashkent State University of Uzbek Language and Literature Faculty of Translation Theory and Practice, Ermanov Davron , Ergasheva Zilola ,   Tashkent State University of Uzbek Language and Literature Faculty of Translation Theory and Practice
Published: June 2024

Providing constructive feedback and giving assessment are integral parts of methodology. They are complex because of motivational and emotional effects on students when they receive it. Sofar, many researchers investigated this part of methodology to find solutions to the problems some of which still exists.In this study.We investigate the importance of assessment and feedback for students' learning process with the help of the previous researches and university students' conceptions of assessment and feedback. They are asked to participate in questionnaire related to evaluation and constructive feedback. The results of survey seems to prove that students’ perspectives towards evaluation and feedback must be studied much further.
THE USE OF DIGITAL EDUCATIONAL PLATFORMS IN THE PROCESS OF TEACHING ENGLISH
Authors:   Alisher Navo'i named after Tashkent state university of uzbek language and literature, Khasanova Maftuna
Published: June 2024

This article is devoted to the study of the features of the organization of distance learning in the subject area "English" using modern digital educational platforms. The purpose of the study is to explore the educational possibilities of this didactic tool in organizing the educational process in a foreign language, improving individual language skills and abilities of students. The article discusses the main classifications of educational platforms, criteria for their selection, provides a list of Internet resources of this type, their characteristics, features of work, substantiates the relevance of using this teaching tool in English lessons and its pedagogical value.
INTERACTIVE METHODS IN DISTANCE LANGUAGE LEARNING: ADVANTAGES AND CHALLENGES
Authors:   Tashkent University of Information Technologies, Razzakova Gulchekhra
Published: June 2024

Thistextexplorestheuseofdistancelearning methods,printing, telecommunications,andtheinternetinforeignlanguageeducationassources of information not only for language acquisition but also for enhancing students' intellectual abilities. It describes the benefits of learning languages through information and communication technologies, the development of communication skills without the need for extensive vocabulary. The challenges facing distance learning are discussed, as well as the importance of choosing the right method for educational success. Special attention is given to the interactive method of teaching, its advantages, and criteria for effective implementation in distance education.
ASSESSMENT CHALLENGES IN THE CREDIT SYSTEM OF EDUCATION IN UZBEKISTAN
Authors:   Tashkent University of Information Technologies, Salakhova Elza
Published: June 2024

The implementation of a credit system in education is a significant reform aimed at enhancing flexibility, transparency, and student mobility within higher education systems. In Uzbekistan, the adoption of a credit-based system has presented various assessment challenges, including issues related to standardization, quality assurance, and alignment with international standards. This article examines the assessment challenges faced within the credit system of education in Uzbekistan and proposes strategies for addressing these challenges to ensure the effectiveness and credibility of the system.