bluuebunny/crossref_metadata_2025 huggingface dataset:
2-Mercaptobenzimidazole Based Hydrazone Derivatives as Potential Antioxidant and α-Glucosidase Inhibitors
Authors: Yousaf Muhammad , Khan Momin , Ali Mumtaz , Shams Waqas Ahmad , Ali Mahboob
Published: April 2022

Background:

Schiff bases are organic compounds and play a vital role in making biologically active compounds in various fields of chemistry. It shows antioxidant, antidepressant, antimalarial, anti-inflammatory, antiglycation, and antimicrobial activity.

Objective:

Our current study is focused on synthesizing thirty-four 2-mercaptobenzimidazole (MBI) based novel hydrazone derivatives (09-42) which were examined for antioxidant free radical scavenging activity via both 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2) assay and explored their alpha-glucosidase inhibitory potential at various concentrations.

Methods:

Multistep reactions were involved in the synthesis of 2-mercaptobenzimidazole-based hydrazone derivatives. All steps of the reaction were carried out under different conditions through a reflux condenser to get the final target products, and the reaction was monitored regularly in each step through thin layer chromatography (TLC). The antioxidant and α-glucosidase inhibition assay was performed.

Results::

Obtained results of antioxidants confirmed that compounds 42 (IC50 = 27.21μg/mL), 36 (IC50 = 27.90μg/mL), 23 (IC50 = 28.10μg/mL) and 35 (IC50 = 45.60μg/mL) possess excellent potential activity compared to standard ascorbic acid having (IC50 = 60.15 μg/mL) in DPPH assay. While in the case of H2O2 three compounds 38 (IC50 = 51.45 μg/mL), 15 (IC50 = 53.50 μg/mL), and 42 (IC50 = 60.42 μg/mL) showed excellent activity as compared to standard Gallic acid having (IC50= 60.67 μg/mL). In the screened compounds against alpha-glucosidase, compound 14 (IC50 = 162 μg/mL) was found to be the most active in the whole series. Another active compound 42 (IC50 = 237μg/mL) possessed moderate inhibitory potency against α-glucosidase enzyme.

Conclusion:

The different biological activities of these novel compounds may be due to different groups in the main skeleton of 2-mercaptobenzimidazole. Further experimental analysis and assessment of these compounds are important because they may lead to better antioxidants used in foods, cosmetics, and health-related products and act as antidiabetic drug development.
Liposomal Drug Delivery and Its Potential Impact on Cancer Research
Authors: Bhattacharya Sankha , Saindane Dnyanesh , Prajapati Bhupendra G.
Published: April 2022

Liposomes are one of the most versatile drug carriers due to their functional properties, such as higher biocompatibility, the ability to encapsulate hydrophilic and hydrophobic products, and higher biodegradability. Liposomes are a better and more significant nanocarrier for cancer therapy. The key to developing a better cancer-targeted nanocarrier is the development of targeted liposomes using various approaches. Several traditional and novel liposome preparation methods are briefly discussed in this mini-review. The current state of liposome targeting, active and passive liposome targeting in cancer therapy, ligand directed targeting (antibody, aptamer, and protein/peptide-mediated targeting), and other miscellaneous approaches such as stimuli-responsive liposome-based targeting, autophagy inhibition mediated targeting, and curcumin loaded liposomal targeting are all discussed within. All of this gathered and compiled information will shed new light on liposome targeting strategies in cancer treatment and will pique the interest of aspiring researchers and academicians.
Recent Literature Review on Coumarin Hybrids as Potential Anticancer Agents
Authors: Katari Naresh Kumar , Bala Muhammad D. , Shaik Baji Baba , Seboletswe Pule , Gundla Rambabu , Kushwaha Narva Deshwar , Kumar Vishal , Singh Parvesh , Karpoormath Rajshekhar
Published: April 2022

Cancer is considered one of the leading causes of death globally, especially patients with lung, pancreatic, or brain tumors are most likely to die of cancer, and patients with prostate and breast cancer are at a high risk of noncancer death. As a result, there is ongoing research regarding developing new, safe, and efficient anticancer agents. Coumarin-based naturally occurring compounds possess a broad spectrum of activity in medicinal chemistry, such as anticancer, anti-inflammatory, antimicrobial, antioxidant agents, etc. Many researchers have synthesized coumarinbased novel therapeutic agents via molecular hybridization technique, which offers an excellent opportunity to develop novel compounds with improved biological activities by incorporating two or more pharmacophores. This review aims to shed light on the recent developments of coumarin-based anticancer hybrid derivatives and their Structure-Activity Relationships (SAR). This review serves as a medium that medicinal chemists could utilize to design and synthesize coumarin derivatives with significant pharmacological value as future anticancer agents.
COVID-19 Vaccination, Peltzman Effect and Possible Increase in Highrisk Behaviors: A Growing Concern Related to Risk Compensation and Reduced Compliance to Public Health Protective Measures after Vaccines Rollout
Authors: Falahi Shahab , Mohamadi Jasem , Sayyadi Hojjat , Pakzad Iraj , Rashidi Ayoub , Naserifar Razi , Abdi Jahangir , Kenarkoohi Azra
Published: April 2022

The world is still faced with widespread dissemination and many unanswered questions related to Coronavirus disease (COVID-19). Several candidate vaccines have been introduced against COVID-19, mostly requiring the injection of two doses and some with nearly 90-95% efficacy. All strategies against the spread of infection have focused on breaking the chain of virus transmission through protective public health measures and mass vaccination. The current situation emphasizes the global need for carefully designed policies to maximize vaccine access and uptake. The risk compensation theory (Peltzman Effect) states that the decrease in perceived risk through access to preventive measures may lead to increasing frequency of risky behaviors. The current pandemic has exposed people to the sense of risk compensation and behavior change in response to the perceived risk. Risk compensation phenomenon may significantly reverse the benefits of COVID-19 vaccination, especially if the vaccine is not sufficiently effective in real life or among high-risk populations. Recognition and awareness of Peltzman risk compensation are of high importance in counteracting and neutralizing the false complacency of the community, which also lends more weight to public health efforts. The public health messages and practices should be clearly expressed, straightforward, reliable and applicable. It is important to encourage mass vaccination of the population, and other NPIs must be re-established and implemented to ensure education to live with COVID-19 in parallel with daily activities and job tasks.
Dopamine as a Potential Target for Learning and Memory: Contributing
to Related Neurological Disorders
Authors: Kourosh-Arami Masoumeh , Komaki Alireza , Zarrindast Mohammad-Reza
Published: April 2022

It is well established that learning and memory are complex processes. They involve and
recruit different brain modulatory neurotransmitter systems. Considerable evidence points to the involvement
of dopamine (DA) in learning and memory. Manifestations of the synaptic spatial localization
of the effect of DA have gained a great deal of interest. Despite the molecular cloning of the five
DA receptor subtypes, the underlying signaling of the DA receptors in spatial learning and memory is
less compelling. Fluctuations in the DA level in the brain are associated with many diseases that comprise
deficits in learning and memory, including Parkinson's disease, Huntington’s disease, schizophrenia,
and Alzheimer's disease. This review aims to briefly summarize existing information regarding
the memory performance modified by DA. The signaling of the DA system, particularly examining
the origin of DA-modulated memory, is also discussed. Then, several kinds of memories in which
DA plays a critical role, including reward signaling, working memory, and long-term plasticity, as
well as memory consolidation, are also described. Finally, memory impairment in some DA-related
neurological disorders is also examined.
Therapeutic Effects of Thymoquinone on Alzheimer’s Disease through Modulating Amyloid-beta Neurotoxicity and Neuro-inflammatory Cytokine Levels
Authors: Alasmari Fawaz , Alotaibi Farraj M. , Al-Qahtani Wedad Saeed , AlAsmari Abdullah F. , Alqahtani Faleh
Published: April 2022

Alzheimer’s disease (AD) is a neurodegenerative disease that involves several impaired neuronal pathways. Modulating the amyloid-beta (β-amyloid) system is being tested to treat AD. Amyloid-beta neurotoxicity is associated with neuroinflammation and plaque formation, further progressing to AD. Protecting neurons from β-amyloid neurotoxicity could be an efficient strategy for the treatment of AD. Thymoquinone (TQ) is an active ingredient in Nigella sativa (NS) and has shown effective therapeutic properties in AD models. TQ was able to attenuate the behavioral dysfunctions in AD models. Moreover, TQ could attenuate the neuroinflammation properties in animals with AD. In addition, studies have shown that TQ could modulate β-amyloid neurotoxicity, an effect associated with improved AD behavioral symptoms. In this review, we highlighted the therapeutic effects of TQ on the progression of AD through modulating β-amyloid neurotoxicity and neuro-inflammatory cytokine levels. Other phenolic compounds also present in NS improved behavioral and neuronal impairments in AD models, supporting TQ’s anti-Alzhiemer’s efficacy.
Cinacalcet HCl-Loaded PLGA Nanoparticles Using the Porous Carrier
Authors: Shree Dipthi , Patra Chinam N. , Ghose Debashish , Jena Goutam K. , Sahoo Biswa M. , Panigrahi Kahnu C. , Sruti Jammula
Published: April 2022

Background:

Cinacalcet HCl is a calcimimetic, BCS class IV drug with low oral bioavailability.
Polymeric nanoparticles are widely used as biomaterials owing to their biocompatibility, biodegradability,
varied structures, low toxicity, and simple and easy formulation process.

Objective:

The aim of the study was to enhance the oral bioavailability of poorly water-soluble drug,
i.e., cinacalcet HCl, by using a suitable particulate nanocarrier system, i.e., polymeric nanoparticles.

Methods:

Biodegradable Cinacalcet HCl (CH)-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles
were prepared by nanoprecipitation method using Poloxamer-188 as a stabilizer. The experimental
parameters, like polymer concentration, stabilizer concentration, temperature, and RPM speed,
were optimized. An optimized polymeric nanoparticle formulation PNP (F8) was solidified by adsorption
on the porous carrier sylysia 350.

Results:

PNP (F8) exhibited a particle size of 155 nm with low PDI (0.231) and high zeta potential (-
21.3 mV). In vitro diffusion study revealed sustained release of CH for 24 h for both PNP (F8) and solidified
PNP (F8). Pharmacokinetics after oral administration of PNP (F8) and solidified PNP (F8) exhibited
a 5-fold increase in bioavailability. Thus, both PNP (F8) and solidified PNP (F8) showed significant
improvement in oral bioavailability.

Conclusion:

Adsorption of polymeric nanoparticles onto porous carriers like sylysia 350 can be considered
as a promising approach for long-term stability.
Política de asistencia social y reducción de la pobreza de China: desarrollo, principales medidas, e inspiración para el alivio de la pobreza mundial
Authors: Jian Lan , Jiejie Guo
Published: April 2022

La política de asistencia social y reducción de la pobreza de China es un requisito esencial para aliviar la pobreza y satisfacer las necesidades básicas de las personas que viven en la base de la sociedad y no pueden obtener una fuente de sustento por sus propios medios. Este artículo resume el desarrollo de la política de China y sus principales medidas de asistencia social dirigidas a combatir la pobreza y analiza sus posibles contribuciones para aliviar la pobreza global. Los principales hallazgos del estudio son que: la asistencia social es un factor clave dentro de la política de reducción de la pobreza y dicha política es la base del sistema perfecto de seguridad social; el sistema multinivel de políticas para la reducción de la pobreza ha logrado que se desarrolle una sinergia institucional ejemplar; la política integral de reducción de la pobreza y la política de alivio de la pobreza y desarrollo se han conectado eficazmente; y los servicios de base y los mecanismos de supervisión también han sido mejorados de manera continua. Adicionalmente, el sostenido desarrollo económico de China ha brindado un apoyo financiero estable para implementar su política y su gobierno se ha comprometido a mejorar el sistema, añadiéndole importancia a la construcción de una red de seguridad para el sustento de las personas, y estableciendo un sistema integral de políticas para la reducción de la pobreza. Al formar un mecanismo de responsabilidad liderado por el gobierno y complementado por fuerzas sociales, China ha construido un mecanismo de ajuste de las políticas compatible con el desarrollo social, para innovar la gobernanza social de base, con el objetivo de mejorar continuamente el desempeño de la reducción de la pobreza. Una mirada al proceso histórico de reducción de la pobreza de China puede inspirar la gobernanza de la pobreza en el mundo.
Publicly Available, Interactive Web-Based Tools to Support Advance Care Planning: Systematic Review
Authors: Dupont Charlèss , Smets Tinne , Monnet Fanny , Pivodic Lara , De Vleminck Aline , Van Audenhove Chantal , Van den Block Lieve
Published: April 2022

Background

There is an increasing number of interactive web-based advance care planning (ACP) support tools, which are web-based aids in any format encouraging reflection, communication, and processing of publicly available information, most of which cannot be found in the peer-reviewed literature.

Objective

This study aims to conduct a systematic review of web-based ACP support tools to describe the characteristics, readability, and quality of content and investigate whether and how they are evaluated.

Methods

We systematically searched the web-based gray literature databases OpenGrey, ClinicalTrials.gov, ProQuest, British Library, Grey Literature in the Netherlands, and Health Services Research Projects in Progress, as well as Google and app stores, and consulted experts using the following eligibility criteria: web-based, designed for the general population, accessible to everyone, interactive (encouraging reflection, communication, and processing of information), and in English or Dutch. The quality of content was evaluated using the Quality Evaluation Scoring Tool (score 0-28—a higher score indicates better quality). To synthesize the characteristics of the ACP tools, readability and quality of content, and whether and how they were evaluated, we used 4 data extraction tables.

Results

A total of 30 tools met the eligibility criteria, including 15 (50%) websites, 10 (33%) web-based portals, 3 (10%) apps, and 2 (7%) with a combination of formats. Of the 30 tools, 24 (80%) mentioned a clear aim, including 7 (23%) that supported reflection or communication, 8 (27%) that supported people in making decisions, 7 (23%) that provided support to document decisions, and 2 (7%) that aimed to achieve all these aims. Of the 30 tools, 7 (23%) provided information on the development, all of which were developed in collaboration with health care professionals, and 3 (10%) with end users. Quality scores ranged between 11 and 28, with most of the lower-scoring tools not referring to information sources.

Conclusions

A variety of ACP support tools are available on the web, varying in the quality of content. In the future, users should be involved in the development process of ACP support tools, and the content should be substantiated by scientific evidence.

Trial Registration

PROSPERO CRD42020184112; https://tinyurl.com/mruf8b43
Developing a Technology Acceptability and Usage Survey (TAUS) for mHealth Intervention Planning and Evaluation in Nigeria: Pilot Study
Authors: Lynch Kathleen A , Atkinson Thomas M , Omisore Adeleye D , Famurewa Olusola , Olasehinde Olalekan , Odujoko Oluwole , Alatise Olusegun I , Egberongbe Adedeji , Kingham T Peter , Morris Elizabeth A , Sutton Elizabeth
Published: April 2022

Background

Technology acceptability and usage surveys (TAUS) are brief questionnaires that measure technology comfort, typical daily use, and access in a population. However, current measures are not adapted to low- and middle-income country (LMIC) contexts.

Objective

The objective of this pilot study was to develop a TAUS that could be used to inform the implementation of a mobile health (mHealth) intervention in Nigeria.

Methods

A literature review of validated technology comfort and usage scales was conducted to identify candidate items. The draft measure was reviewed for face validity by an expert panel comprised of clinicians and researchers with cultural, methodological, and clinical expertise. The measure was piloted by radiologists at an oncology symposium in Nigeria.

Results

After expert review, the final measure included 18 items organized into 3 domains: (1) comfort with using mobile applications, (2) reliability of internet or electricity, and (3) attitudes toward using computers or mobile applications in clinical practice. The pilot sample (n=16) reported high levels of comfort and acceptability toward using mHealth applications in the clinical setting but faced numerous infrastructure challenges.

Conclusions

Pilot results indicate that the TAUS may be a feasible and appropriate measure for assessing technology usage and acceptability in LMIC clinical contexts. Dedicating a domain to technology infrastructure and access yielded valuable insights for program implementation.
Translating Promoting Factors and Behavior Change Principles Into a Blended and Technology-Supported Intervention to Stimulate Physical Activity in Children With Asthma (Foxfit): Design Study
Authors: Brons Annette , Braam Katja , Broekema Aline , Timmerman Annieck , Millenaar Karel , Engelbert Raoul , Kröse Ben , Visser Bart
Published: April 2022

Background

Children with asthma can decrease the impact of their disease by improving their physical activity (PA). However, health care providers lack interventions for children with asthma that effectively increase their PA levels and achieve behavior change. A technology-supported approach can positively influence PA and physical functioning in children.

Objective

The aims of this study were to develop a technology-supported intervention that facilitates health care providers in promoting PA for children (aged 8 to 12 years) with asthma and to systematically describe this developmental process.

Methods

Intervention mapping (IM) was applied to develop a blended and technology-supported intervention in cocreation with children with asthma, their parents, and health care providers. In accordance with the IM framework, the following steps were performed: conduct a needs assessment; define the intervention outcome, performance objectives, and change objectives; select theory-based intervention methods and strategies; create components of the intervention and conduct pilot tests; create an implementation plan; and create an evaluation plan.

Results

We developed the blended intervention Foxfit that consists of an app with a PA monitor for children (aged 8 to 12 years) with asthma and a web-based dashboard for their health care provider. The intervention focuses on PA in everyday life to improve social participation. Foxfit contains components based on behavior change principles and gamification, including goal setting, rewards, action planning, monitoring, shaping knowledge, a gamified story, personal coaching and feedback, and a tailored approach. An evaluation plan was created to assess the intervention’s usability and feasibility for both children and health care providers.

Conclusions

The IM framework was very useful for systematically developing a technology-supported intervention and for describing the translational process from scientific evidence, the needs and wishes of future users, and behavior change principles into this intervention. This has led to the technology-supported intervention Foxfit that facilitates health care providers in promoting PA in children with asthma. The structured description of the development process and functional components shows the way behavior change techniques are incorporated in the intervention.

Trial Registration

International Clinical Trial Registry Platform NTR6658; https://tinyurl.com/3rxejksf
Type 1 Diabetes Hypoglycemia Prediction Algorithms: Systematic Review
Authors: Tsichlaki Stella , Koumakis Lefteris , Tsiknakis Manolis
Published: April 2022

Background

Diabetes is a chronic condition that necessitates regular monitoring and self-management of the patient’s blood glucose levels. People with type 1 diabetes (T1D) can live a productive life if they receive proper diabetes care. Nonetheless, a loose glycemic control might increase the risk of developing hypoglycemia. This incident can occur because of a variety of causes, such as taking additional doses of insulin, skipping meals, or overexercising. Mainly, the symptoms of hypoglycemia range from mild dysphoria to more severe conditions, if not detected in a timely manner.

Objective

In this review, we aimed to report on innovative detection techniques and tactics for identifying and preventing hypoglycemic episodes, focusing on T1D.

Methods

A systematic literature search following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was performed focusing on the PubMed, GoogleScholar, IEEEXplore, and ACM Digital Library to find articles on technologies related to hypoglycemia detection in patients with T1D.

Results

The presented approaches have been used or devised to enhance blood glucose monitoring and boost its efficacy in forecasting future glucose levels, which could aid the prediction of future episodes of hypoglycemia. We detected 19 predictive models for hypoglycemia, specifically on T1D, using a wide range of algorithmic methodologies, spanning from statistics (1.9/19, 10%) to machine learning (9.88/19, 52%) and deep learning (7.22/19, 38%). The algorithms used most were the Kalman filtering and classification models (support vector machine, k-nearest neighbors, and random forests). The performance of the predictive models was found to be satisfactory overall, reaching accuracies between 70% and 99%, which proves that such technologies are capable of facilitating the prediction of T1D hypoglycemia.

Conclusions

It is evident that continuous glucose monitoring can improve glucose control in diabetes; however, predictive models for hypo- and hyperglycemia using only mainstream noninvasive sensors such as wristbands and smartwatches are foreseen to be the next step for mobile health in T1D. Prospective studies are required to demonstrate the value of such models in real-life mobile health interventions.
An Electronic Patient-Reported Outcomes Tool for Older Adults With Complex Chronic Conditions: Cost-Utility Analysis
Authors: Miranda Rafael N , Bhuiya Aunima R , Thraya Zak , Hancock-Howard Rebecca , Chan Brian CF , Steele Gray Carolyn , Wodchis Walter P , Thavorn Kednapa
Published: April 2022

Background

eHealth technologies for self-management can improve quality of life, but little is known about whether the benefits gained outweigh their costs. The electronic patient-reported outcome (ePRO) mobile app and portal system supports patients with multiple chronic conditions to collaborate with primary health care providers to set and monitor health-related goals.

Objective

This study aims to estimate the cost of ePRO and the cost utility of the ePRO intervention compared with usual care provided to patients with multiple chronic conditions and complex needs living in the community, from the perspective of the publicly funded health care payer in Ontario, Canada.

Methods

We developed a decision tree model to estimate the incremental cost per quality-adjusted life year (QALY) gained for the ePRO tool versus usual care over a time horizon of 15 months. Resource utilization and effectiveness of the ePRO tool were drawn from a randomized clinical trial with 6 family health teams involving 45 participants. Unit costs associated with health care utilization (adjusted to 2020 Canadian dollars) were drawn from literature and publicly available sources. A series of sensitivity analyses were conducted to assess the robustness of the findings.

Results

The total cost of the ePRO tool was CAD $79,467 (~US $ 63,581; CAD $1733 [~US $1386] per person). Compared with standard care, the ePRO intervention was associated with higher costs (CAD $1710 [~US $1368]) and fewer QALYs (–0.03). The findings were consistent with the clinical evidence, suggesting no statistical difference in health-related quality of life between ePRO and usual care groups. However, the tool would be considered a cost-effective option if it could improve by at least 0.03 QALYs. The probability that the ePRO is cost-effective was 17.3% at a willingness-to-pay (WTP) threshold of CAD $50,000 (~US $40,000)/QALY.

Conclusions

The ePRO tool is not a cost-effective technology at the commonly used WTP value of CAD $50,000 (~US $40,000)/QALY, but long-term and the societal impacts of ePRO were not included in this analysis. Further research is needed to better understand its impact on long-term outcomes and in real-world settings. The present findings add to the growing evidence about eHealth interventions’ capacity to respond to complex aging populations within finite-resourced health systems.

Trial Registration

ClinicalTrials.gov NCT02917954; https://clinicaltrials.gov/ct2/show/NCT02917954
Impact of a Mobile Application for Tracking Nausea and Vomiting During Pregnancy (NVP) on NVP Symptoms, Quality of Life, and Decisional Conflict Regarding NVP Treatments: MinSafeStart Randomized Controlled Trial
Authors: Ngo Elin , Truong Maria Bich-Thuy , Wright David , Nordeng Hedvig
Published: April 2022

Background

Pregnant women are active users of mobile apps for health purposes. These apps may improve self-management of health-related conditions. Up to 70% of pregnant women experience nausea and vomiting (NVP). Even mild NVP can significantly reduce quality of life (QoL), and it can become an economic burden for both the woman and society. NVP often occurs before the first maternal care visit; therefore, apps can potentially play an important role in empowering pregnant women to recognize, manage, and seek appropriate treatment for NVP, when required.

Objective

This study investigated whether the MinSafeStart (MSS) mobile app could impact NVP-related symptoms, QoL, and decisional conflict regarding NVP treatment.

Methods

This randomized controlled trial enrolled 268 pregnant women with NVP in Norway from 2019 to 2020. The intervention group had access to the MSS app, which could be used to track NVP symptoms and access tailored advice. NVP severity was rated with the Pregnancy Unique Quantification of Emesis (PUQE) score. The control group followed standard maternal care. We collected data on maternal baseline characteristics, NVP severity, QoL, and decisional conflict using 2 sets of online questionnaires. One set of questionnaires was completed at enrollment, and the other was completed after 2 weeks. We performed linear regression analyses to explore whether the use of the MSS app was associated with NVP severity, QoL, or decisional conflict.

Results

Among the 268 women enrolled in the study, 192 (86.5%) completed the baseline questionnaires and were randomized to either the intervention (n=89) or control group (n=103). In the intervention group, 88 women downloaded the app, and 468 logs were recorded. In both groups, women were enrolled at a median of 8 gestational weeks. At baseline, the average PUQE scores were 4.9 and 4.7; the average QoL scores were 146 and 149; and the average DCS scores were 40 and 43 in the intervention and control groups, respectively. The app had no impact on NVP severity (aβ 0.6, 95% Cl −0.1 to 1.2), QoL (aβ −5.3, 95% Cl −12.5 to 1.9), or decisional conflict regarding NVP treatment (aβ −1.1, 95% Cl −6.2 to 4.2), compared with standard care.

Conclusions

Tracking NVP symptoms with the MSS app was not associated with improvements in NVP symptoms, QoL, or decisional conflict after 2 weeks, compared with standard care. Future studies should include a process evaluation to improve our understanding of how pregnant women use the app and how to optimize its utility within maternity care. Specifically, studies should focus on how digital tools might facilitate counseling and communication between pregnant women and health care providers regarding NVP management during pregnancy.

Trial Registration

ClinicalTrails.gov (NCT04719286): https://www.clinicaltrials.gov/ct2/show/NCT04719286
Behavioral Health Professionals’ Perceptions on Patient-Controlled Granular Information Sharing (Part 1): Focus Group Study (Preprint)
Authors: Ivanova Julia , Tang Tianyu , Idouraine Nassim , Murcko Anita , Whitfield Mary Jo , Dye Christy , Chern Darwyn , Grando Adela
Published: April 2022

BACKGROUND

Patient-controlled granular information sharing (PC-GIS) allows a patient to select specific health information “granules,” such as diagnoses and medications; choose with whom the information is shared; and decide how the information can be used. Previous studies suggest that health professionals have mixed or concerned opinions about the process and impact of PC-GIS for care and research. Further understanding of behavioral health professionals’ views on PC-GIS are needed for successful implementation and use of this technology.

OBJECTIVE

The aim of this study was to evaluate changes in health professionals’ opinions on PC-GIS before and after a demonstrative case study.

METHODS

Four focus groups were conducted at two integrated health care facilities: one serious mental illness facility and one general behavioral health facility. A total of 28 participants were given access to outcomes of a previous study where patients had control over medical record sharing. Participants were surveyed before and after focus groups on their views about PC-GIS. Thematic analysis of focus group output was paired with descriptive statistics and exploratory factor analysis of surveys.

RESULTS

Behavioral health professionals showed a significant opinion shift toward concern after the focus group intervention, specifically on the topics of patient understanding (P=.001), authorized electronic health record access (P=.03), patient-professional relationship (P=.006), patient control acceptance (P<.001), and patient rights (P=.02). Qualitative methodology supported these results. The themes of professional considerations (2234/4025, 55.5% of codes) and necessity of health information (260/766, 33.9%) identified key aspects of PC-GIS concerns.

CONCLUSIONS

Behavioral health professionals agreed that a trusting patient-professional relationship is integral to the optimal implementation of PC-GIS, but were concerned about the potential negative impacts of PC-GIS on patient safety and quality of care.
Peer Review of “Toward Human Digital Twins for Cybersecurity Simulations on the Metaverse: Ontological and Network Science Approach” (Preprint)
Authors: Oladele Daniel Ayo
Published: April 2022

UNSTRUCTURED

This is a peer review report related to ms#33502.
Effect of Explant Types and Benzyl Amino Purine Concentrations on the In Vitro Regeneration of Several Local Eggplant Cultivars
Authors: Erniwitama Erniwitama , Taryono Taryono , Murti Rudi Hari
Published: April 2022

Eggplant as a vegetable is generally fresh consumed. Besides having a high nutritive value, eggplant contains solasonine and solamargine, which act as an antibacterial that can inhibit cancer cells, gastrictic and respiratory disorders. Eggplant also provides a unique system to study in vitro regeneration since it can be induced from different explants by different growth regulators and morphogenetic pathways. This study aims to observe the effect of explant types and BAP concentrations on the in vitro regeneration of three eggplant cultivars, Rimbang,  Tanteloh and Limao. Leaf and hypocotyl explants were cultured on MS semi solid medium supplemented with BAP and IBA in combination. BAP tested at 1, 2 and 3 mgL-1 while IBA tested at 1 mgL-1. Medium containing 1 mgL-1 IBA used for rooting of regenerated shoot. The experiment was arranged in completely randomized design with five replicates. Each replicate consisted of five leaves and hypocotyl explants. Cultures were incubated at 25±10C, 65% humidity, and 16 hours per day photoperiod. Observation was done for 8 weeks of culture. The result indicated that leaf explants showed shoot initiation within 5 – 9 days of cultured, while hypocotyl explants showed the response within 7 – 12 days of cultured. Shoots formation preceded by swollen on the explants surface followed by emerging light green shoot. Leaf explants cultured on medium supplemented with 3 mgL-1 BAP + 1 mgL-1 IBA showed the maximum number of shoots regeneration while hypocotyl explants showed less of shoots  in all medium. Similarly, leaf explants cultured on medium supplemented with 3 mgL-1 BAP + 1 mgL-1 IBA showed the maximum number of roots. Among the cultivars, Rimbang showed the best response than other cultivars.
Pengaruh Aerasi dan Kadar Air Awal terhadap Kinerja Pengomposan Kotoran Sapi Sistem Windrow
Authors: Hapsari Umi
Published: April 2022

AbstractThis study aims to determine the effect of material composition and initial moisture content on composting performance on active and passive aeration with a pile system. The parameters observed were changes in temperature, pH, moisture content, degradation of organic matter and germination. The treatment in this study is composting with different initial moisture content and closed windrow conditions. There are 3 variations of the mixture of ingredients. Variation A mixture of cow dung with sawdust is given active aeration. Variation B mixture of cow manure with vegetable waste is given active aeration. Variation C mix cow dung with passive EM4 aeration. The optimal initial moisture content for composting is 50 - 60%. Open windrow conditions during the composting process result in a high percentage of water content reduction and heat loss occurring in the pile. The degree of acidity (pH) of composting for each treatment shows an acceptable pH range of 8 - 9. The degradation of organic matter is related to the high composting temperature the higher the composting temperature the higher the microbial activity so that the process of degradation of organic matter is faster. AbstrakPenelitian ini bertujuan untuk mengetahui pengaruh komposisi bahan dan kadar air awal terhadap kinerja pengomposan pada aerasi aktif dan pasif dengan sistem tumpukan. Parameter yang diamati adalah perubahan suhu, pH, kadar air, degradasi bahan organik dan perkecambahan. Perlakuan dalam penelitian ini adalah pengomposan dengan kadar air awal berbeda dan kondisi tumpukan (windrow) tertutup. Terdapat 3 variasi campuran bahan. Variasi A campuran kotoran sapi dengan serbuk gergaji diberi aerasi aktif. Variasi B campuran kotoran sapi dengan limbah sayur diberi aerasi aktif. Variasi C campuran kotoran sapi dengan EM4  aerasi pasif. Kadar air awal yang optimal untuk pengomposan adalah 50 – 60%. Kondisi tumpukan (windrow) yang terbuka selama proses pengomposan mengakibatkan persentase penurunan kadar air yang tinggi dan diikuti terjadinya panas hilang pada tumpukan. Derajat keasaman (pH) pengomposan untuk masing – masing perlakuan menunjukan rentang pH yang dapat diterima yaitu 8 – 9. Degradasi bahan organik berhubungan dengan suhu pengomposan yang tinggi semakin tinggi suhu pengomposan maka aktivitas mikrobia semakin tinggi sehingga proses degradasi bahan organik semakin cepat.
Business Model among Home Industries in Kulon Progo
Authors: Sari Pinjung Nawang , Jumeri Jumeri , Puspoyudo Filigon Adiguna
Published: April 2022

Business model is a system of resources and activities, which create a value that is useful to the customer and the sale of this value makes money for the company. The purpose of the analysis of business models is to deepen and broaden the knowledge about basic components of a business model. The Business Model Canvas (BMC) is a tool that provides a clear view of what the company needs to achieve and focuses on the strategic elements that matter most and will have the greatest impact to the business. This paper discuss about BMC among home industries in Kulon Progo Regency, based on their products: “pong” tofu, white tofu, traditional snacks, various kind of “peyek”, dan various kind of tempeh (soybean, “gembus”, and “benguk”). These five home industries compared among the nine building blocks in the BMC: customer segments, customer relationships, distribution channels, value proposition, key resources, key activities, partners, cost structure and revenue streams. BMC helps the home industries in creating their business models based on nine building blocks. Discussion among these home industries in Kulon Progo Regency was being conducted in order to help the entrepreneurs to use these models in the right way‚ and successfully plan their future business.
Analisis Intertekstualitas di Relief Candi Prambanan Makna Fisik Wanita
Authors: Siagian Ade Onny , Wijoyo Hadion
Published: April 2022

The existence of women, especially regarding their physical beauty and beauty, is not a myth found in works of art or literature, including those found in temple reliefs. Many temple reliefs in Indonesia depict women and their exoticism, both physically and their activities and position in society. Prambanan Temple is a temple that is known to be closely related to the figure of a beautiful woman named Roro Jongrang who occupies the main statue. In addition to the main statue, on the reliefs of the walls of Prambanan Temple there are also reliefs about other women. This relief is a text that describes women and their existence. This study seeks to explore and interpret the physical woman on the wall reliefs of Prambanan Temple. The research was conducted by using semiotic-semanalytic analysis of Juli Kristeva. The results of the intertextual research show that almost all of the women's physical relief panels at Prambanan Temple are constructed to read the signs on the reliefs as a text, so that the story or story conveyed can be easily recognized and understood. The meaning of genotext in the context of women on temple wall reliefs who appear without a physical cover or naked is a common thing or a habit in society based on geographical and social conditions. The upper physical nudity of women at that time did not affect the views of the people around, especially men. Because women are chosen not based on their body shape but other attractions that are sometimes mystical. The meaning of phenotext, women who appear naked has a negative meaning and leads to pornography, can cause unlimited male attraction, can become victims of sexual crimes, and can even be in contact with the law.
A CRITICAL ANALYSIS OF CONTEMPORARY COUNTER-TERRORISM
Authors: Ilic Aleksandra
Published: April 2022

In this paper the author analyses the contemporary counter-terrorism especially in the context of relevant international and national regulatives. The author first considers counter-terrorism measures in investigation of crimes of terrorism. In the name of protecting states and citizens, “war on terrorism” in some countries legitimized many actions directed towards the suppression of any potential danger from terrorism. Some boundaries have been crossed when the treatment of suspicious individuals is concerned and in that sense the author discusses the use of torture in fight against terrorism. Another issue that is subject of disscusion in this paper is treatment of persons convicted for terrorism. There are two dimensions of that treatment. On the one side is penintentiary treatment ie. the process which take place in prisons and on the other side we can talk about post-penal treatment of convicts for terrorism. The author criticizes the way how dominant approach in contemporary penintentiary and postpenal treatment of terrorists – the program of deradicalization, is realizing. Finally, the author considers counter-terrorism activities of some countries during the Covid-19 pandemic and possible future situation when it comes to terrorism which will influences the application of counter-terrorism measures.
НЕТРАДИЦИОННЫЕ МЫСЛИ о MWC 2022
Authors: Тихвинский В.
Published: April 2022

С 28 февраля по 3 марта 2022 года в г. Барселона (Испания) состоялись традиционный Всемирный мобильный конгресс MWC Barcelona 2022 и выставка последних достижений в области мобильных (и не только) телекоммуникаций.
ТЕЛЕКОММУНИКАЦИОННЫЕ СИСТЕМЫ ДЛЯ РАЗВИТИЯ АРКТИЧЕСКОЙ ЗОНЫ РОССИИ
Authors: Раткин Л.
Published: April 2022

В Москве, в конгресс-центре ТПП РФ, 2-3 марта состоялась VII Международная конференция "АРКТИКА-2022". На круглом столе в ее рамках "Цифровизация для развития Арктической зоны Российской Федерации" рассказывалось о новых разработках для российского сегмента Арктики, в частности телекоммуникационных систем.
USER DEFINED GEOMETRIC FEATURE FOR THE CREATION OF THE FEMORAL NECK ENVELOPING SURFACE
Authors: Stojković Miloš , Trifunović Milan , Milovanović Jelena , Arsić Stojanka
Published: April 2022

There is a growing demand for application of personalized bone implants (endoprostheses or macro-scaffolds, and fixators) which conform the anatomy of patient. Hence the need for a CAD procedure that enables fast and sufficiently accurate digital reconstruction of the traumatized bone geometry. Research presented in this paper addresses digital reconstruction of the femoral neck fracture. The results point out that User-Defined (geometric) Feature (UDF) concept is the most convenient to use in digital reconstruction of numerous variants of the same topology, such as in this kind of bone region. UDF, named FemoNeck, is developed to demonstrate capability of the chosen concept. Its geometry, controlled by a dozen of parameters, can be easily shaped according to anatomy of femoral neck region of the specific patient. That kind of CAD procedure should use minimally required set of geometric (anatomical) parameters, which can be easily captured from X-ray or Computed Tomography (CT) images. For the statistical analysis of geometry and UDF development we used CT scans of proximal femur of 24 Caucasian female and male adults. The validation of the proposed method was done by applying it for remodeling four femoral necks of four different proximal femurs and by comparing the geometrical congruency between the raw polygonal models gained directly from CT scan and reconstructed models.
FORCED NONLINEAR OSCILLATOR IN A FRACTAL SPACE
Authors: He Ji-Huan , Moatimid Galal M. , Zekry Marwa H.
Published: April 2022

A critical hurdle of a nonlinear vibration system in a fractal space is the inefficiency in modelling the system. Specifically, the differential equation models cannot elucidate the effect of porosity size and distribution of the periodic property. This paper establishes a fractal-differential model for this purpose, and a fractal Duffing-Van der Pol oscillator (DVdP) with two-scale fractal derivatives and a forced term is considered as an example to reveal the basic properties of the fractal oscillator. Utilizing the two-scale transforms and He-Laplace method, an analytic approximate solution may be attained. Unfortunately, this solution is not physically preferred. It has to be modified along with the nonlinear frequency analysis, and the stability criterion for the equation under consideration is obtained. On the other hand, the linearized stability theory is employed in the autonomous arrangement. Consequently, the phase portraits around the equilibrium points are sketched. For the non-autonomous organization, the stability criteria are analyzed via the multiple time scales technique. Numerical estimations are designed to confirm graphically the analytical approximate solutions as well as the stability configuration. It is revealed that the exciting external force parameter plays a destabilizing role. Furthermore, both of the frequency of the excited force and the stiffness parameter, execute a dual role in the stability picture.
IMPACT OF THE NUMBER OF VEHICLES ON TRAFFIC SAFETY: MULTIPHASE MODELING
Authors: Damjanović Milanko , Stević Željko , Stanimirović Dragan , Tanackov Ilija , Marinković Dragan
Published: April 2022

Traffic safety is one of the key issues nowadays, given the fact that a large number of people lose their lives in traffic accidents every day. There are various influential factors in the occurrence of traffic accidents, the number of vehicles being one of them. This paper assesses the traffic safety in Montenegro in the period 1998-2020 by applying the multiphase modeling with a purpose to obtain comparative results which enable implementation of adequate strategies. A total of six scenarios were formed with two inputs and two outputs in a DEA (Data Envelopment Analysis) model, with the number of registered vehicles per year being an input in all scenarios. In addition, as inputs, the scenarios included AADT (Annual Average Daily Traffic), passengers in road transport, passenger-km by road transport, goods transported by road, tone-km by road, and passengers in local transport. The number of traffic accidents with casualties, the number of traffic accidents with material damage, the number of fatal cases and the number of injured persons, depending on a scenario, were observed as outputs. After the DEA model, IMF SWARA (Improved Fuzzy Stepwise Weight Assessment Ratio Analysis) was applied to determine the weights of inputs and outputs, while the final state of traffic safety by years was determined using the MARCOS (Measurement of alternatives and ranking according to COmpromise solution) method.
Resiliensi Usaha MIkro, Kecil, Menengah (UMKM) dan Kebijakan Pemerintah di Masa Pandemi Covid 19
Authors: Raharjo Dewi Amaliah Nafiati , Endang Sri Mulyani
Published: April 2022

Micro, Small, and Medium Enterprises (MSMEs) are businesses that play an important and strategic role as a stabilizer and dynamics of economic development in Indonesia. UMKM resilience also has tested when Indonesia experienced a monetary crisis in 1997. Currently, Indonesia is experiencing a crisis again caused by the COVID pandemic 19. The COVID 19 pandemic crisis has had a significant impact on the sustainability of MSME. Almost all MSMEs suffer losses, have difficulty running their operational activities, and even have to close down their businesses because their products cannot be absorbed by the market. This condition is again testing the resilience of MSMEs to be able to deal with the 19th COVID pandemic crisis. Various strategies have been developed to get out of this crisis. Among others by optimizing the online-based sales system that utilizes a variety of marketplace platforms to market their products. The role of the government is very important to help MSMEs to be strong in facing the COVID pandemic crisis 19. Monetary policies such as relaxation of loans, delaying installments and interest on loans as well as social assistance are a breath of fresh air for MSMEs to be able to breathe a little between the crush of the COVID pandemic crisis 19.