bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial Heterogeneity of Fault Slip and the Radiated Spectra of Ground Motions
Authors: Beresnev Igor A.
Published: March 2022

Kinematic models of simulating earthquake radiation in seismic hazard analysis typically require prescribing the distribution of final slip over the hypothetical fault planes. The spatial spectra of heterogeneous slip affect the frequency spectra of the seismic body waves. The representation integral of elasticity provides a convenient analytical tool by which the relationships between the slip spectra in the wavenumber domain and the wave spectra in the frequency domain can be scrutinized. In the limit of the waves from a small source in the far field, the Fourier spectrum of wave displacement is the spectrum of the slip-rate function multiplied by the spatial slip spectrum representing fault directivity. A popular model for the latter is the k-square slip distribution. Classic results prescribe that for a typical ω-square source time function, such multiplication, conversely to a common assumption that the k-square slip distribution always leads to the ω-square decay of the high-frequency seismic spectra, can result in the ω−4 power-law decay. Such steep fall-off rates are highly unusual in observations, suggesting that the k-square heterogeneous slip in certain cases may significantly underpredict the realistic high-frequency ground motions, including peak velocities and accelerations. An alternative use of heterogeneous slip distributions would be to explain the additional high-frequency diminution of the observed spectra that is usually attributed to ad hoc cutoff (“fmax” or “kappa”) filters. The simple asymptotic relationships between heterogeneous fault slip and body wave spectra may not hold true in the vicinity of large earthquakes, at distances of main interest to hazard calculations.
Integrated Analysis of the 2020 Mw 7.4 La Crucecita, Oaxaca, Mexico, Earthquake from Joint Inversion of Geodetic and Seismic Observations
Authors: Yan Zhe , Xiong Xiong , Liu Chengli , Xu Jiao
Published: March 2022

On 23 June 2020, a major thrust faulting earthquake ruptured the megathrust near a sharp transition of the plate boundary beneath the Mexico subduction zone, overlapping the rupture area of the 1965 Mw 7.5 (Ms 7.6) event. A joint inversion of geodetic and seismic observations and prediction of coastal uplifts indicate a compact rupture with a peak slip of ∼3.6 m. The cumulative seismic moment is 1.41×1020  N·m within 20 s of coseismic rupture, giving a moment magnitude of Mw 7.4. The rupture propagated with a relatively high rupture speed (∼3.5 km/s) downdip at depths from 20 to 30 km, terminating at the edge of a slow slip region. The energy-related static stress drop is ∼8.1 MPa. The aftershock distribution and the region where slow slip events occurred show a clear complementary relationship with the coseismic rupture zone of the 2020 Oaxaca event. The high-stress drop and associated deep compact rupture pattern suggest a homogeneous asperity with high strength beneath the Oaxaca region. Comparisons of rupture areas, mechanisms, and seismic waveforms show that the 2020 Mw 7.4 Oaxaca earthquake is a quasi-repeat of the 1965 earthquake. The inferred recurrence interval is ∼55 yr. Static stress transfer from mainshock may trigger near trench aftershocks but has small loading on the megathrust interface in the Tehuantepec seismic gap.
Analysis of the morphological changes of the beaches along the segment València - Cullera (E Spain) from satellite-derived shorelines
Authors: Pardo-Pascual Josep E. , Palomar-Vázquez Jesús M. , Cabezas-Rabadán Carlos
Published: March 2022

Beaches are spaces of paramount importance for coastal societies currently threatened by coastal erosion. Their preservation requires accurate quantification of their changes in order to understand their behavior and to propose efficient solutions. Landsat 8 and Sentinel 2 mid-resolution satellites offer free-of-charge images with great potential for coastal monitoring. From them, it is possible to automatically extract the shoreline position as a quantitative indicator of the beach morphology over large territories and with high temporal frequency. Beach changes take place at different spatial and temporal scales, typically responding to coastal storms and human interventions on the coast. The collection of large packages of satellite-derived shorelines (SDS) at the coastal sector València-Cullera (W Mediterranean) covering the period 2013-2020 makes it possible to characterize the state of its beaches and their width changes over space and time.Results reveal a widespread erosional trend, most likely caused by a shortage of sediment in the coastal system. Thus, the majority of the beaches are not capable of restoring their previous conditions after storm-driven retreats. The information provided by the SDS also shows the ineffectiveness of the nourishment actions, at least in the way they have been carried out, and the urgent need for a strategy to address the erosion problem.
The Customer Engagement Effect on Customer Satisfaction and Brand Trust and Its Impact on Brand Loyalty
Authors: Tuti Meylani , Sulistia Viki
Published: March 2022

Research aims: The research purpose is to determine the influence of customer engagement on brand loyalty through customer satisfaction and brand trust.Design/Methodology/Approach: The population in this research was customers who made purchases from December 2019 until February 2020. The sampling technique employed purposive sampling to decide on 200 respondents. The data had been examined for reliability and validity. The data analysis method used quantitative and descriptive. Structural Equation Modeling (SEM) was utilized in the quantitative analysis.Research findings: The research results uncovered that customer engagement significantly influenced customer satisfaction. Customer engagement gave a significant influence on brand trust. Customer engagement gave a significant influence on brand loyalty. Customer satisfaction gave a significant influence on brand trust. The brand trust gave a significant influence on brand loyalty. Customer engagement gave an indirect influence on brand trust through customer satisfaction. Also, customer engagement indirectly influenced brand loyalty through brand trust and customer satisfaction.Theoretical contribution/Originality: The study gives contribution to the growth of brand literature.Practitioner/Policy implication: The study has implications for researchers and sellers on how to improve the brand.Research limitation/Implication: The limitation of this study is that it only used one clothing entrepreneurship business brand that utilized Instagram as a promotional medium for further research. Developing the research object further by using more similar brands is recommended.
Primer Diálogo Regional de Política de Industrias Culturales y Creativas con Enfoque Intersectorial: el rol de las industrias culturales y creativas en la reactivación económica de América Latina y el Caribe
Authors: Azuara Herrera Oliver , Grant Kayla , Grazzi Matteo , Herrera Diego , Luzardo Alejandra , Navarrete Jesús , Peinado-Vara Estrella , Prada Eliana , Puig Gabarró Pau , Rodríguez Sylvia , Saravia Eduardo , Rucci Graciana , Zaldívar Trinidad
Published: March 2022

El presente documento recopila las memorias del “Primer diálogo regional de política” de industrias culturales y creativas con enfoque intersectorial, con el propósito de reunir las experiencias y las mejores prácticas disponibles del sector público y privado. Las discusiones giraron en torno a 4 ejes temáticos: Estrategias de desarrollo urbano y local a través de la cultura y la creatividad; Acciones para fortalecer la competitividad del sector creativo a través de la digitalización; Oportunidades para los trabajadores independientes de los sectores creativos; Mecanismos financieros para fomentar la economía creativa.
Evaluación del impacto del COVID-19 en las industrias culturales y creativas
Authors: Triguboff Matías , Zanabria Juan Manuel , Sasso Simone , Cathles Alison , Benzaquen Adriana , Bautista Maximiliano , Séligmann Juan Nicolás , Decuzzi Lara , Mines Cuenya Ana , Castellanos Ribot Alfonso
Published: March 2022

En América Latina, la pandemia del Covid-19 ha tenido efectos dramáticos sobre las industrias culturales y creativas (ICC), tradicionalmente ligadas a trabajadores autónomos con escasa protección social y económica. Al mismo tiempo, estos sectores han experimentado una acelerada digitalización de sus bienes y servicios y la introducción de nuevos modelos de negocio, que les han permitido fortalecer su resiliencia. Con el propósito de lograr un mejor análisis de la situación de las ICC durante la pandemia, el BID, la UNESCO, la SEGIB, la OEI y el MERCOSUR Cultural aunaron recursos y esfuerzos y se embarcaron en una iniciativa conjunta de análisis del impacto del Covid-19 en estas industrias. Esta publicación presenta los resultados principales de este proyecto. Incluye una estimación macroeconómica y microeconómica del impacto de la pandemia en las empresas y los trabajadores culturales y creativos, así como un análisis de las políticas públicas desarrolladas por ministerios y organismos nacionales de Cultura ante la emergencia. Los hacedores de políticas, economistas, trabajadores culturales y creativos, emprendedores, inversores privados, así como investigadores encontrarán en este estudio datos confiables y un análisis en profundidad de las principales tendencias que han caracterizado estos sectores durante la pandemia. Este estudio proporciona una perspectiva regional, que es clave para identificar nuevas oportunidades y fortalecer la cooperación regional en los sectores culturales y creativos
Association between axial length and toric intraocular lens rotation according to an online toric back-calculator
Authors:   Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA, Patnaik Jennifer L. , Berdahl John P. ,   Vance Thompson Vision, Sioux Falls, South Dakota 57108, USA, Hardten David R. ,   Minnesota Eye Consultants, Minneapolis, Minnesota 55404, USA, Wagner Brandie D. ,   Department of Biostatistics, Colorado School of Public Health, Aurora, Colorado 80045, USA, Seibold Leonard K. ,   Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA, Kramer Brent A. ,   Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27517, USA
Published: March 2022

AIM: To assess the relationship between axial length (AL) and intraocular lens (IOL) rotation among eyes receiving a toric IOL and subsequently entered into an online toric back-calculator database.
METHODS: Retrospective analysis of data collected online via astigmatismfix.com, a freely available online toric back-calculator where surgeons enter pre- and post-operative information to help manage residual postoperative astigmatism. Included records were deemed valid with entry of AL and IOL orientation between January 2017 and March 2019. Rotation was determined by a difference of ≥5° between pre-operative intended IOL orientation and actual post-operative IOL orientation. Frequency and magnitude of rotation are presented with means and associated standard deviation (SD). Linear regression models of this association are presented.
RESULTS: Records of 6752 eyes were included in the analysis, of which 74.8% were determined to have a rotated IOL. The magnitude of rotation increased with each millimeter (mm) increase in AL with a mean rotation of 13.3° (SD: 12.8°) for eyes with AL 20-20.9 mm and a maximum mean rotation of 30.6° (SD: 30.3°) among eyes with AL 29-29.9 mm. General linear modeling demonstrated a significant association (P<0.0001) with a parameter estimate of 1.19 (standard error: 0.159) and R2 of 0.0083.
CONCLUSION: Analysis from an online database indicates that toric IOLs inserted into eyes with longer AL are more likely to rotate and to rotate more degrees from the target axis. The findings from this study are clinically relevant for surgeons implanting toric IOLs.
Scleral remodeling in myopia development
Authors:   Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, China, Yu Qi
Published: March 2022

With the increasing prevalence in recent years, myopia has become an essential global health concern. In most instances, an increased axial length of the eye is the structural cause of nearsightedness. The scleral remodeling, primarily dependent on the scleral extracellular matrix (ECM) changes, is significantly linked to eye lengthening. Scleral remodeling plays a critical function in the incidence and progression of myopia. This mini-review will focus on recent research progress of scleral remodeling in the hope of providing new ideas for the prophylaxis and treatment of myopia.
The registry of congenital Cleft lip and cleft palate in Iran: Three-years pilot results and learned lessons
Authors: Habibelahi Abbas , Bahrami Naghmeh , Mohammadi Farnoush , Sarmadi Sarvin , Amirzade-Iranaq Mohammad Hosein , Farhangiyan Masoume , Bayat Mohammad
Published: March 2022

Introduction: Cleft lip and cleft palate are the most common maxillofacial congenital defects leading to facial deformity and complications in nutrition, respiration, and social interaction. The current study aims to report early findings of the pilot registry for congenital Cleft lip and cleft palate in Iran and discuss limitations and further goals to collect and implicate information of cleft newborn patients.
Methods: A 3-year hospital-based multicenter prospective cohort study of The Congenital Cleft lip and cleft palate Registry was performed in various hospitals in Iran from 2018 to 2020. Newborns with oral clefts were included, and The type of cleft, location, geographical place, and gender of each patient were recorded. The descriptive statistics were reported as means and percentages analyzed with Fisher exact test using SPSS software ver. 22 (IBM, Chicago, US). The P-value < 0.05 considered as significant.
Results: From 336 registered newborns with Cleft lip and cleft palate, 40.1% were females, while 59.9% were males. The prevalence of lip cleft was 31.5%, while 17.6% have palate cleft. Also, 50.9% suffer from both cleft lip and palate simultaneously. (P-value<0.05) The frequent location of clefts were bilateral Cleft lip and cleft palate with 50% of the cases (P-value<0.05). Also, 28.2% and 21.8% had right-side and left side unilateral Cleft lip and cleft palate, respectively. Tabriz, Mashhad, Tehran were the most frequent location of clefts.
Conclusion: Despite the primary statistics and trends presented in this study, the data quality could improve through some limited modifications. Also, the provinces with a high prevalence of congenital deformities need critical attention and provide adequate healthcare.
Clinicopathological Presentation of Oral Squamous Cell Carcinoma in Iraqi population
Authors: Mahmood Bayad Jaza , Gataa Ibrahim Saeed , Muhammad Mustafa Umed
Published: March 2022

Background and Aim: Oral cancer is a major public health issue worldwide; it remains a highly lethal and disfiguring disease, it is primarily a disease of epithelial origin, it has various clinicopathological pictures. is to demonstrate various clinical and pathological presentations of oral squamous cell carcinoma in Iraqi population.
Materials and Methods: A total of 80 cases of histologically diagnosed squamous cell carcinoma collected from the main centers of Sulaymaniyah teaching hospital/Hiwa cancer center Hospital/Sulaymaniyah/Iraq were analyzed according to age, sex, site, clinical, and pathological presentation of oral squamous cell carcinoma at the time of presentation, and histological grading.
Results: Patients in their sixth decade of life were the most commonly affected with a male-to-female ratio of 1.4:1. The tongue was the most frequently affected site, followed by the floor of the mouth. The most common clinical presentation is ulceration and swelling. More than 40% of the cases were well-differentiated squamous cell carcinoma.
Conclusion: Oral cancer is increasingly seen as a major health problem, in line with the general trend in the region, the need for inter-professional health care delivery approaches for reducing oral cancer mortality and improving patients’ quality of life.
Pattern of impacted teeth among patients at MNH
Authors: Anandumi Kanankira , Kalyanyama Boniphace , Moshy Jeremiah Robert , Sohal Karpal Singh , Simon Elison NM
Published: March 2022

Introduction: An impacted tooth is the one which fails to attain its normal functional position within the expected developmental period. They are associated with various pathologies. Hence, the aim of this study was to determine the pattern of occurrence, presentation, and management of impacted teeth among patients attending Muhimbili National Hospital.

Materials and Methods: This was a cross-sectional hospital-based study that included all patients aged≥21 years and had impacted teeth. The patients were interviewed using a specially designed questionnaire and later examined clinically and radiographically. Data obtained was an- alyzed using SPSS version 23.0.

Results: A total of 4,668 patients comprising of 1938 (41.5%) males and 2730 (58.5%) females were attended. Among these, 264 (5.6%) patients comprising of 152 (57.6%) males and 112 (42.4%) females had impacted teeth. The 21-25 years age group was the most (59.2%) commonly affected. Mandibular third molars were the most (64.9%) impacted teeth followed by 167 (33.4%) maxillary third molars. Pain was the most common complaint in 79.1% of patients. Mesio-angular impaction was the most common angulation in 196 (39.9%) impacted teeth, followed by vertical impaction in 142 (28.7%) and disto-angular 103 (21.0%) impacted teeth. A majority (66.6%) of impacted teeth were treated by open surgical removal followed by 53 (10.5%) impactions by closed disimpaction.

Conclusion: The occurrence of impacted teeth among the patients attended at MNH was 5.6%. Mandibular third molars were the most commonly impacted teeth with mesio-angular being the commonest type of angulation of impacted teeth. Pericoronitis was the most common pathology associated with impacted teeth, others included dental caries, ameloblastoma, and dentigerous cysts. Surgical disimpaction was the most frequently used treatment method with good healing results.
Odpowiedź polskich gmin na pierwszą falę kryzysu COVID-19
Authors: Kańduła Sławomira , Przybylska Joanna
Published: March 2022

Polish municipalities’ response to the first wave of the COVID -19 crisis Purpose: The purpose of this chapter is to identify the initial responses of municipalities to the emergence of the COVID-19 pandemic. Design/methodology/approach: The research questions posed were: What types of budgetary instruments were used by municipalities during the first months of the COVID-19 pandemic in Poland? What was the scale of the loss of their current revenues and what was the amount of expenditures related to countering COVID-19? What were the sources of funding for these expenditures? Findings: Municipalities were, by necessity, on the front line of the fight against the effects of the pandemic. They used the available budgetary instruments (local taxes and fees, property revenues, budgetary expenditures) to limit the spread of the virus and reduce its negative consequences. These actions were not coordinated. The study revealed that revenue losses and expenditure increases due to COVID-19 were not as large as expected. Originality and value: The research in this chapter demonstrates that municipalities in Poland used different approaches to develop and implement policies to counteract the spread of the COVID-19 pandemic and mitigate its effects. The research shows that Polish municipalities played a leading role in the rapid response to the pandemic, although their actions varied and were uncoordinated.
Estudo do escoamento pluvial superficial na rua General Osvaldo Pinto da Veiga, Criciúma, Santa Catarina
Authors: Maccarini Maria Eugenia , Cauduro Flávia
Published: March 2022

Os alagamentos vem sendo problemas corriqueiros em vários centros urbanos. Tais empecilhos têm sido decorrente da urbanização que tende a impermeabilizar o solo e acelerar o escoamento por condutos e canais. Este processo produz o aumento da vazão máxima e o  aumento da velocidade do escoamento (TUCCI, 2012). A partir desse cenário surge a importância de estudos para a implementação de sistemas alternativos de drenagem urbana, com o objetivo de reduzir os impactos e minimizar os danos causados pelas inundações. Dentre esses sistemas, destacam-se as técnicas compensatórias, que visam a redução da vazão de pico por meio de sua infiltração (BENINI, 2015). Os pavimentos permeáveis podem ser utilizados especialmente em estacionamentos e ruas com tráfego leve, assim contribuindo para os sistemas de drenagem como uma maneira de amenizar o escoamento superficial (FILHO, 2019). O aproveitamento de água da chuva consiste basicamente em coletar água que cai sobre os telhados e armazená-las em reservatórios para o uso futuro. Este método pode ser visto como um meio de evitar enchentes além de resultar em economia de água potável (DUDZEVCH, 2009). Este trabalho propõe um estudo sobre o escoamento pluvial superficial de parte da Rua General Osvaldo Pinto da Veiga localizada na cidade de Criciúma, Santa Catarina.
Caracterização socioeconômica e ambiental de quintais urbanos em Marituba, estado do Pará
Authors: Silva Jamilly Raiane Siqueira da , Barbosa Antônia do Socorro Aleixo , Coelho Alexia Ohana Carlos da Silva , Costa Brenda Moraes , Albuquerque Kleberson Almeida de , Araújo Janayna Galvão de , Saraiva Joyce Dos Santos , Santos Marcos Antônio Souza dos
Published: March 2022

O trabalho analisa as características socioeconômicas e ambientais de quintais urbanos no município de Marituba, Região Metropolitana de Belém, estado do Pará. Os dados foram obtidos a partir da aplicação de 32 questionários, junto aos participantes do projeto Quintais Amazônicos Maritubenses, tecnologia social que desenvolve metodologias, técnicas e produtos em interação com a comunidade, visando inclusão produtiva e transformação social. Entre as famílias entrevistadas, 50% moram no município há mais de 15 anos, 81% são mulheres, o que evidencia o intenso protagonimo feminino no processo produtivo dos quintais. Constatou-se que 62% dos entrevistados possuem mais de 40 anos de idade e 41% possuem ensino médio completo. Espécies frutíferas, plantas medicinais e hortaliças compõem os grupos de plantas mais cultivados nos quintais, com percentuais de ocorrência de 91%, 72% e 72%, respectivamente, destacando-se dentro destes o limão (Citrus aurantiifolia), a pimenta dedo-de-moça (Capsicum baccatum L.) e a hortelã (Mentha spicata L.). A implementação do projeto Quintais Amazônicos Maritubenses, além de proporcionar o incremento na renda por meio da fabricação de subprodutos para comercialização, ampliou o nível de conscientização ambiental das famílias que passaram a reutilizar alguns materiais para a adubação dos quintais urbanos e aplicar defensivos naturais no controle de pragas e doenças das plantas cultivadas.
A Contribuição da Teoria Geral dos Sistemas e do Pensamento Complexo para o Entendimento dos Sistemas de Inovação Nacional/Regional
Authors: Brito Vivian Costa , Miranda Ronaldo Leão de , Santos Gilberto Friedenreich dos , Souza Cristiane Mansur de Moraes
Published: March 2022

A complexidade dos sistemas de inovação nacional e regional pode ser analisada a partir da teoria geral dos sistemas e do pensamento complexo aplicado a um dado contexto territorial. Nessa perspectiva, o objetivo deste estudo é compreender qual a contribuição da teoria geral dos sistemas e do pensamento complexo para o entendimento dos sistemas de inovação nacional/regional. Diante disso, tem-se que a teoria dos sistemas auxilia no entendimento das unidades e as alterações escalares (micro, meso e macro) entre subsistemas que compõe os sistemas de inovação, suas relações entre si, que caracteriza sua vulnerabilidade ou resiliência. Portanto, as experiências apresentadas sobre sistemas de inovação refletem a realidade dos países ao Norte em melhor contexto de desenvolvimento do que os países ao Sul. Por isso, devem ser analisadas como referenciais epistemológicos apenas para suscitar questionamentos e possibilidades diante do contexto dos países ao Sul. Pois, há indicações que para atingir tais resultados é preciso superar as desigualdades, exigindo políticas orientadas para a constituição do sistema.
Propagandanın Güncelliği: Yirminci Yüzyıl Teorisinden Dersler
Authors: TAS Oguzhan
Published: March 2022

Propaganda günümüzde yeniden güç kazanıyor ve demokrasinin epistemik krizinin bir parçası olarak karşımıza çıkıyor. Yirminci yüzyılda propagandayla ilişkili düşünülen pek çok fenomen yeni yüzlerle aramızda; yalan haber, dezenformasyon, “troll”ler, komplo teorileri ve benzerleri. Buna karşılık propaganda hakkında geçmiş yüzyılda yürütülmüş teorik tartışmalar artık pek hatırlanmıyor. Bu yazının amacı, iki dünya savaşı arasındaki dönemde propagandanın sarsıcı etkisini kavramaya çalışan yaklaşımları hatırlatmak ve bunların güncel tartışmalara nasıl eklemlenebileceğini araştırmak. I. ve II. Dünya Savaşı arasındaki dönem, propagandanın tanımlanışına dair farklılaşan kavrayışlara sahne olmuştur. Bu dönemdeki tartışma ve eleştirilerin, bugün propaganda üzerine nasıl düşünebileceğimiz konusunda bize pek çok yeni tartışmadan daha fazla ışık tutabileceğini iddia ediyoruz. Bunun için ilk olarak Amerikan pozitivist sosyolojisi ve siyaset bilimi çerçevesinde propaganda sorununun nasıl ele alındığını inceliyoruz. Ardından Frankfurt Okulu’nun Amerika Birleşik Devletleri’nde, faşist propagandanın araç ve teknikleriyle ilgili yürüttüğü araştırmaları değerlendiriyoruz. Bu iki başlık, propaganda sorununa farklı düşünsel kaynaklar ve metodolojik araçlarla yönelmenin nasıl farklı kavrayışlarla sonuçlandığını gösteriyor. Sonraki bölümde ise propagandanın yeni medya ekolojisi içindeki varlığını hem bu teorik tartışmalarla hem de yalan haber, hakikat sonrası ve sosyal medya manipülasyonu gibi güncel kavramlarla ilişkilendiriyoruz. Propagandanın günümüzün medya ve siyaset dünyasında gücünü hala koruduğunu öne süreceğimiz bu bölümde, yalan haberlerin yaygınlığı karşısında çözümü genellikle teknolojiye havale eden yaklaşımların barındırdığı sorunlara da işaret ediyoruz.
The relationship of lamins with epigenetic factors during aging
Authors: Mustafin R. N. , Khusnutdinova E. K.
Published: March 2022

The key factor of genome instability during aging is transposon dysregulation. This may be due to senile changes in the expression of lamins, which epigenetically modulate transposons. Lamins directly physically interact with transposons. Epigenetic regulators such as SIRT7, BAF, and microRNA can also serve as intermediaries for their interactions. There is also an inverse regulation, since transposons are sources of miRNAs that affect lamins. We suggest that lamins can be attributed to epigenetic factors, since they are part of the NURD, interact with histone deacetylases and regulate gene expression without changing the nucleotide sequences. The role of lamins in the etiopathogenesis of premature aging syndromes may be associated with interactions with transposons. In various human cells, LINE1 is present in the heterochromatin domains of the genome associated with lamins, while SIRT7 facilitates the interaction of this retroelement with lamins. Both retroelements and the nuclear lamina play an important role in the antiviral response of organisms. This may be due to the role of lamins in protection from both viruses and transposons, since viruses and transposons are evolutionarily related. Transposable elements and lamins are secondary messengers of environmental stressors that can serve as triggers for aging and carcinogenesis. Transposons play a role in the development of cancer, while the microRNAs derived from them, participating in the etiopathogenesis of tumors, are important in human aging. Lamins have similar properties, since lamins are dysregulated in cancer, and microRNAs affecting them are involved in carcinogenesis. Changes in the expression of specific microRNAs were also revealed in laminopathies. Identification of the epigenetic mechanisms of interaction of lamins with transposons during aging can become the basis for the development of methods of life extension and targeted therapy of age-associated cancer.
Association between ТР53, MDM2 and NQO1 gene polymorphisms and viral load among women with human papillomavirus
Authors: AlBosale A.H. , Mashkina E. V.
Published: March 2022

The risk of cervical cancer is caused by persistent human papillomavirus (HPV) infection. Cervical cancer is the most frequent cancer among women. Our purpose was to investigate the association between TP53 215C>G (Pro72Arg), MDM2 -410T>G, and NQO1 609C>T gene polymorphisms with a high HPV load and the influence of gene-gene interactions on prolonged HPV infection. Eighty-nine women with a high HPV viral load and 114 healthy women were involved in a case–control study. Genotyping for TP53 215C>G (Pro72Arg) and MDM2 -410T>G SNPs was carried out by allele-specific PCR and genotyping for NQO1 609C>T was performed by a TaqMan assay. Quantitative analysis of HPV DNA was performed by AmpliSens® HPV HCR screen-titer-FRT test system. Gene-gene interactions were analyzed using the multifactor dimensionality reduction (MDR) method. The study of separate SNPs of MDM2 -410T>G and NQO1 609C>T genes did not reveal any statistically significant difference in genotype and allele frequencies among women within the two groups. The frequency of the 215G (72Arg) allele and 215GG (72Arg/Arg) genotype of the TP53 gene was significantly higher in the case group than in the control group (OR = 1.74, 95 % CI = 1.10–2.73; p = 0.02 and OR = 1.97, 95 % CI = 1.13–3.46; p = 0.04, respectively). MDR analysis showed the significance of intergenic interactions of the three studied loci TP53 (rs1042522) – MDM2 (rs2279744) – NQO1 (rs1800566) for the formation of a high HPV load (OR = 3.05, 95 % CI = 1.73–5.46; p = 0.0001).
A bioinformatic search for correspondence between differentially expressed genes of domestic versus wild animals and orthologous human genes altering reproductive potential
Authors: Ponomarenko M. P. , Chadaeva I. V. , Ponomarenko P. M. , Bogomolov A. G. , Oshchepkov D. Yu. , Sharypova E. B. , Suslov V. V. , Osadchuk A. V. , Osadchuk L. V. , Matushkin Yu. G.
Published: March 2022

One of the greatest achievements of genetics in the 20th century is D.K. Belyaev’s discovery of destabilizing selection during the domestication of animals and that this selection affects only gene expression regulation (not gene structure) and influences systems of neuroendocrine control of ontogenesis in a stressful environment. Among the experimental data generalized by Belyaev’s discovery, there are also findings about accelerated extinction of testes’ hormonal function and disrupted seasonality of reproduction of domesticated foxes in comparison with their wild congeners. To date, Belyaev’s discovery has already been repeatedly confirmed, for example, by independent observations during deer domestication, during the use of rats as laboratory animals, after the reintroduction of endangered species such as Przewalski’s horse, and during the creation of a Siberian reserve population of the Siberian grouse when it had reached an endangered status in natural habitats. A genome-wide comparison among humans, several domestic animals, and some of their wild congeners has given rise to the concept of self-domestication syndrome, which includes autism spectrum disorders. In our previous study, we created a bioinformatic model of human self-domestication syndrome using differentially expressed genes (DEGs; of domestic animals versus their wild congeners) orthologous to the human genes (mainly, nervous-system genes) whose changes in expression affect reproductive potential, i.e., growth of the number of humans in the absence of restrictions caused by limiting factors. Here, we applied this model to 68 human genes whose changes in expression alter the reproductive health of women and men and to 3080 DEGs of domestic versus wild animals. As a result, in domestic animals, we identified 16 and 4 DEGs, the expression changes of which are codirected with changes in the expression of the human orthologous genes decreasing and increasing human reproductive potential, respectively. The wild animals had 9 and 11 such DEGs, respectively. This difference between domestic and wild animals was significant according to Pearson’s χ2 test (p < 0.05) and Fisher’s exact test (p < 0.05). We discuss the results from the standpoint of restoration of endangered animal species whose natural habitats are subject to an anthropogenic impact.
Sexual dimorphism in the robusticity of long bones of infants and young children
Authors: Coussens Anna , Anson Tim , Norris Rachel M. , Henneberg Maciej
Published: March 2022

It is difficult to determine the sex of subadult skeletal remains because there is a little sexual dimorphism present pre-pubertally. In a historic sample of 24 children aged 0-4 years from St. Mary's Anglican Church,Marion, South Australia, the robustness of femora and of humeri was correlated with sexually dimorphic mandibular morphology. Ratios of midshaft circumference to diaphyseal length of humeri and femora and the ratio of minimum circumference to diaphyseal length of the humerus showed correlation with sex determined by mandibular morphology, male indices being greater than the female ones. The humerus midshaft circumference index showed the greatest difference between sexes (P value=0.0002). The results need confirmation on known-sex skeletal remains, but for the moment this robusticity dimorphism seems to be a new discovery for osteological practice.
Sekretarz króla Stanisława Leszczyńskiego – agent czy wierny sługa
Authors: Durbas Małgorzata
Published: March 2022

Celem niniejszego opracowania jest przedstawienie sylwetki osobistego (przybocznego) sekretarza króla Stanisława Leszczyńskiego w Lotaryngii zarówno jako agenta, jak i wiernego sługi. Podstawę źródłową do napisania tejże pracy stanowią materiały pochodzące z Bibliotheque Municipale de Nancy i polskich archiwów.
Czasy saskie w opiniach epoki stanisławowskiej (po 1772 r.)
Authors: Stroynowski Andrzej
Published: March 2022

Autor w swojej pracy skupia się przeanalizowaniu opinii ludzi epoki stanisławowskiej na temat epoki saskiej. Głębszej analizie poddaje czasy po pierwszym rozbiorze Polski, kiedy to dokonywały się przemiany poglądów politycznych, gdy zmieniały się oceny saskiego panowania, którego żywa pamięć powoli wygasała i była zastępowana przez sądy, które wynikały bardziej z bieżących potrzeb politycznych niż z rzeczywistej znajomości dawnych realiów.
TEORIJA KOMUNIKATIVNOG DELOVANJA: KONTEKST ZA RAZUMEVANJE PRIRODE ZNANJA U PEDAGOGIJI
Authors: Prlić Ivana
Published: March 2022

U radu se razmatra teorija komunikativnog delovanja Jirgena Habermasa kao kontekst za razumevanje prirode znanja u pedagogiji. Polazeći od ideja Frankfurtske škole kritičke teorije Habermas smatra da je znanje vođeno trima različitim interesima: tehničkim, praktičnim i emancipatorskim. Zagovara komunikativnu racionalnost, neprinudno učešće subjekata u komunikaciji u kojoj ih ujedinjuje snaga argumentativnog govora. Veruje da je konsenzus moguć u situaciji idealnog govora, oslobođenoj od svih vidova spoljne moći, nejednakosti i represije. Jedina moć koja važi i odnosi pobedu u komunikaciji je snaga boljeg argumenta. Znanje koje se ustanovi kroz ovaj intersubjektivni akumulativni proces stalno nadograđujućih, nastajućih konsenzusa u puno različitih situacija idealnog govora je vođeno navedenim interesima, pa je znanje uvek interesno znanje u nekoj od tri paradigme. U radu je dalje razmatrano kakvo značenje za pedagogiju imaju neke od ključnih Habermasovih ideja. Kritike koje različiti autori upućuju teoriji komunikativnog delovanja su diskutovane kroz dovođenje u odnos sa određenim stanovištima u pedagogiji. Shodno tome, naročita pažnja posvećena je razumevanju dijaloga u obrazovanju.
PROFESIONALNO UČENJE U KONTEKSTU SUVREMENE KONCEPCIJE RANOG I PREDŠKOLSKOG ODGOJA I OBRAZOVANJA
Authors: Stojković Jadranka
Published: March 2022

Suvremena koncepcija ranog i predškolskog odgoja i obrazovanja etablira odgojno- obrazovne ustanove kao kompleksne sustave koji su ujedno i samoorganizirajući što implicira važnost osvještavanja svih sudionika odgojno-obrazovnog procesa o njihovoj suodgovornosti za kontinuirano uvođenje promjena na svim razinama. Stoga profesionalno učenje treba sagledavati kao participacijski proces pri čemu sudionici odgojno-obrazovnog procesa koji zajedno uče i istražuju čine profesionalne zajednice učenja, odnosno skupine akcijskih istraživača. Ovo istraživanje je imalo za cilj utvrditi prisutnost profesionalno pedagoških svojstava, karakteristika i kompetencija kod zaposlenih u ustanovama za rani i predškolski odgoj i obrazovanje. Istraživanje je provedeno na uzorku od 604 ispitanika zaposlenih u ustanovama za rani i predškolski odgoj i obrazovanje na području Zagreba i zagrebačke županije. Dobiveni podaci obrađeni su u statističkom SPSS paketu (deskriptivna analiza, faktorski rezultati na ekstrahiranim Promax dimenzijama) ukazuju da odgojno-obrazovni djelatnici u ustanovama ranog i predškolskog odgoja i obrazovanja imaju izražene profesionalno pedagoške kompetencije.
ZNAČAJ PROCENE VIZUO-MOTORNE INTEGRACIJE KOD DECE PREDŠKOLSKOG UZRASTA
Authors: Jovanić Tamara , Slavković Sanela
Published: March 2022

Vizuo-motorna integracija (VMI) predstavlja nivo usklađenosti vizuelne percepcije i fine motorike te je bitno da obe komponente budu pravilno razvijene, ali i da su neometano koordinisane u zajedničku aktivnost. VMI je značajna u svakodnevnim životnim i akademskim aktivnostima. Cilj istraživanja je bio da se utvrdi nivo vizuo-motorne integracije kod dece predškolskog uzrasta, kao i da odgovori na pitanje postoji li veza između vizuo-motorne integracije i određenih socio-demografskih varijabli (pol i uzrast). Uzorak je činilo 74 dece predškolskog uzrasta, od pet godina i jednog meseca do sedam godina i sedam meseci (AS=6,66 godina; SD=0,44 godine). Istraživanje je sprovedeno primenom Razvojnog testa vizuo-motorne integracije (The Beery-Buktenica Developmental Test of Visual-Motor Integration - Beery VMI, Sixth Edition)(Beery & Beery, 2004) i Ček liste o usvojenosti vizuo-motorne integracije kod dece (Visual Processing Disorder – Checklist) nacionalnog udruženja specijalnih edukatora u Sjedinjenim Američkim Državama. Rezultati pokazuju da postoji statistički značajna povezanost između vizuo-motorne integracije, vizuelne percepcije i motorne koordinacije (p<0,05). Takođe, utvrđeno je da devojčice ostvaruju viši nivo postignuća na testu vizuo-motorne integracije od dečaka (p<0,05). Rezultati potvrđuju da je procena vaspitača usaglašena sa postignućima na razvojnom testu VMI. Iako deca na predškolskom uzrastu imaju prosečno razvijenu veštinu vizuo-motorne integracije, bilo bi preporučljivo sprovoditi skrininge iz ove oblasti da bi se na što ranijem uzrastu detektovala eventualna kašnjenja, obzirom na značaj razvijenosti VMI i njene povezanosti sa svakodnevnim aktivnostma i razvojem bazičnih akademskih veština.
Extension of the ELECTRE III Method to the Case of Uncertain Preferences: Application to an Example of the Environmental Management Problem
Authors: ABOUNAIMA Mohammed Chaouki , El MAZOURI Fatima-zahra , LAMRINI Loubna , OUZARF Mohamed , TALIBI ALAOUI Mohammed Chaouk
Published: March 2022

Almost all the decision problems are by nature multi-criteria, where multiple and conflflicting criteria must be considered in the decision-making process. For some cases of these decision problems, they are further marked by a lack of certainty and precision in the decision-maker’s judgments and preferences. This study aims to propose an extension of the ELECTRE III method, widely used in the multi-criteria decision aid fifield, to the case of a decision problem where the decision-maker preferences are imprecise and uncertain. In this proposed adaptation, the inaccuracies and uncertainties will be expressed by an uncertainty interval. The proposed extension will be tested with an example problem to demonstrate its feasibility and relevance. In this example of environmental management, we propose to rank three oil refifinery installation projects from the best project to the worst project. The experiment results show that the ELECTRE III method extension can be used easily and rigorously when the uncertainty intervals express the decision-maker’s preferences. Finally, the results obtained in this work can be extended to other multi-criteria analysis methods.
COVID-19 em Enfermarias Forenses: O Exemplo do Serviço Regional de Psiquiatria Forense (SRPF-CHPL)
Authors: Duarte e Silva Inês , Vieira Fernando , Ferreira Paulo , Cruz Manuel
Published: March 2022

N/d.
Delirium in Patients with Severe COVID-19: Preliminary Results of the MAPA Longitudinal Study
Authors: Martins Sónia , Ferreira Ana Rita , Fernandes Joana , Vieira Tatiana , Fontes Liliana , Coimbra Isabel , Paiva José Artur , Fernandes Lia
Published: March 2022

N/a.
Skills Required of Geriatricians: Why Medical Students Do Not Select Geriatrics as Their Career
Authors: Murakami Manabu , Jin Shigeki , Takeuchi Akiko , Matoba Kotaro
Published: March 2022

N/a.
REFORMULASI ETIKA DAKWAH BERBASIS KOMUNIKASI PROFETIK DALAM AL-QUR’AN
Authors: Ridho Abdul Rasyid , Hariyadi Muhammad
Published: March 2022

Prophetic communication is communication that refers to the prophetic communication pattern of Muhammad Saw. loaded with values ??and ethics. This paradigm is a development of the concept of social prophetic science (ISP) which was initiated by contemporary Islamic scientist, namely Kuntowijoyo. Da'wah as a means of disseminating information through the media in modern times does not always have a positive impact on the purpose of da'wah. In the new era, the media  actually gave birth to many provocative da’wah, which caused divisions and contradictions. It is very sad if the da'is and activists do not integrate ethics and prophetic values. So that the impact can cause a lot of hate speech (hatespeech) and lies (hoaxs) to preach. This phenomenon is very inversely proportional to the teachings of peaceful Islam as practiced by the Prophet Muhammad. Therefore, reformulation of prophetic-based da'wah is very urgent in modern times.
INTENSITAS PEMBERITAAN KEGIATAN KEAGAMAAN PADA SURAT KABAR POSMETRO ROHIL
Authors: Putra Heri Rahmatsyah , Armi Fadhlur Rahman
Published: March 2022

The purpose of this study is to find out the intensity of the reports on Posmetro Rohil's newspaper on religious activities. It attracts the attention of the writer because Posmetro Rohil is a newspaper in the middle of Rokan Hilir's society which is mostly fanatical of religious activities. The method used in this research is a qualitative descriptive with data acquisition through observation, interview, and documentation. It is known from this study that the factor affecting the story of Posmetro Rohil is based on an individual factor that describes that media management personnel do not have a higher tendency towards religious activity. Then outside media factors like resource and media revenue. And the last ideological factor, Posmetro is an independent newspaper and does not bring interest to a particular group. Although news about religious activity is news that tends to attract interest in reading society.
DIDÁTICA E ENSINO DE HISTÓRIA
Authors: Dutra Vanderlene das Neves , Nakashima Rosária Helena Ruiz , Medeiros Olivia Macedo Miranda Cormineiro de Medeiros , Silva Luciano Galdino da
Published: March 2022

Neste artigo, apresentamos alguns elementos que ressaltam as potencialidades pedagógicas dos infográficos no ensino de Didática, na licenciatura em História, a fim de evidenciar como esses recursos podem contribuir para o ensino dos conteúdos da disciplina. Trata-se de uma pesquisa qualitativa e bibliográfica sobre ensino de História, Didática, infográficos e o conceito de “práxis”. A investigação possibilitou explorar o software Piktochart para a produção de infográficos de conteúdos da Didática.  Os resultados nos forneceram indicativos de que o uso dos infográficos, na elaboração de materiais didáticos, pode oferecer aos estudantes e seus professores alternativas de produção e de aperfeiçoamento da sistematização de informações.  Portanto, a partir da integração de recursos tecnológicos, aliados a uma pedagogia inovadora, baseada na práxis, é possível contribuir com processos educativos mais significativos, ampliando seu sentido e significado para estudantes e docentes.
IGREJAS, INSTITUIÇÕES RELIGIOSAS E A ECONOMIA DO COMUM NA AMAZÔNIA
Authors: Carvalho Brandão Juliana , Silva Harley
Published: March 2022

Este trabalho discute a atuação de instituições religiosas, em especial da Igreja Católica Apostólica Romana, enquanto elementos centrais de locais onde emergem relações sociais de produção e reprodução e gestão de recursos de modo comunitário na Amazônia. O estudo analisa, entre outros aspectos históricos e sociais,  uma experiência na cidade de Abaetetuba, no Estado do Pará, na paróquia Cristo Redentor. Ali, foi possível observar práticas do fazer-comum e o papel do compartilhamento e da reciprocidade na vida material da comunidade, e onde se estabeleceu uma nova dinâmica na economia local a partir da festividade do “Festival do açaí”. É intenção deste trabalho a compreensão de como práticas e espaços da vida religiosa na Amazônia articulam relações de produção social de economias camponesas e áreas urbanas à cadeias de circulação de alcance local
Leishmania Proteomics: An in Silico Perspective
Authors: Padilla Carlos A. , Álvarez María J. , Combariza Aldo F.
Published: March 2022

We report on the state of the art of research on proteins recognized as potential targets for the development of Leishmania treatments and the search of active chemical species. We have reviewed information from experimental in vitro, in vivo, or in silico sources. We classify the gathered information on: a) vector taxonomy and geographical distribution, b) parasite taxonomy, geographical distribution, c) enzymatic function of proteins related to the parasite/host in any of its development states, id. est., oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases and cytokines, and d) information on standard and non-standard treatments from bioactive chemical species. Our aim is to provide a much needed reference layout for research efforts aimed to understand the interaction mechanisms of ligand-protein activation/inactivation processes, specifically related to Leishmania, thus, we focus on enzymes known to be part of the biochemical molecular pathways initiated following a Leishmania infectious episode.
Outpatient High-Dose-Rate Mold Brachytherapy for Lower Gingival Squamous Cell Carcinoma: A First Report
Authors: Takeshita Ami , Shimamoto Hiroaki , Uchimoto Yuka , Tsujimoto Tomomi , Miyamoto Tetsuo , Kreiborg Sven , Mallya Sanjay M , Oda Michio , Hirata Takero , Ogawa Kazuhiko , Shiomi Hiroya , Murakami Shumei
Published: March 2022

Brachytherapy is often applied to oral cancers, with good outcomes and minimal loss of oral function. Especially, mold brachytherapy is best suited for superficial oral cancers with little or no bone invasion, such as gingival cancer, palatal mucosal cancer, or buccal mucosal cancer because of the thin tissue thickness that needs to be irradiated. A few cases have been reported on mold brachytherapy for gingival cancers, especially with high-dose-rates (HDR), these treatments were performed during hospitalization. We report a case of lower gingival squamous cell carcinoma (SCC) treated with HDR mold brachytherapy in an outpatient setting. A 71-year-old male with lower gingival SCC had received HDR mold brachytherapy (54 Gy, 9 fractions, 5 days) as an outpatient. Eighteen months after the mold therapy, the patient had no recurrence and no metastasis. A search of the literature revealed no previous report of a case of gingival cancer treated with HDR mold brachytherapy in an outpatient.