bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-center retrospective study of children with sickle cell disease admitted to pediatric intensive care units in the United States
Authors: Ettinger Nicholas A. , Guffey Danielle , Anum Shaniqua J. , Fasipe Titilope , Katkin Julie , Bhar Saleh , Airewele Gladstone , Saini Arun , Tubman Venée N.
Published: April 2023

Data on outcomes and interventions for children with sickle cell disease (SCD) admitted to a pediatric intensive care units (PICU) are unknown. We provide the first comprehensive multi-center report on PICU interventions associated with death, the need for invasive respiratory support or stroke among critically ill children with SCD. We collected retrospective multi-center cohort data from January 1, 2012 to December 31, 2019 utilizing the Virtual Pediatric Systems, LLC database. We identified 3388 unique children with SCD, accounting for a total of 5264 PICU admissions from 138 PICUs. The overall mortality rate for the PICU admissions cohort was 1.8% (95/5264 PICU admissions, 95/3388 [2.8%] of all unique patients), the rate of needing of needing Invasive Respiratory Support (IRS, a composite category of exposure) was 21.3% (872/4093 PICU admissions with complete data) and the overall rate of stroke (ischemic or hemorrhagic) was 12.5% (657/5264 PICU admissions). In multivariable analysis adjusting for admission age category, sex, race/ethnicity, PRISM-3 score at admission, exposure to IRS, quartile of unit volume of patients with SCD, and patient origin, admitted children who needed invasive respiratory support (IRS) had higher adjusted odds ratios for mortality (adjusted odds ratio [aOR], 19.72; 95% confidence interval [CI] 8.98–43.29; p < 0.001), although admitted children > 2 years old had decreased aOR for needing IRS (aOR 0.25–0.62; 95% CI 0.16–0.94; p < 0.001–0.025). By contrast, admitted children > 2 years old had a strikingly increased aOR for stroke (aOR 7.57–16.32; 95% CI 2.25–52.15; p < 0.001). These groups may represent PICU-specific subsets of patients with SCD who are at higher risk for more serious illness and should deserve early consideration for referral to a pediatric institution providing comprehensive care for patients with SCD.
Lectin-based carbohydrate profile of megakaryocytes in murine fetal liver during development
Authors: Bomfim Barbara Cristina Marcollino , Azevedo-Silva Jessyca , Caminha Giulia , Santos João Paulo Rodrigues , Pelajo-Machado Marcelo , de Paula Ayres-Silva Jackline
Published: April 2023

Hematopoiesis is the process by which blood cells are generated. During embryonic development, these cells migrate through different organs until they reach the bone marrow, their definitive place in adulthood. Around E10.5, the fetal liver starts budding from the gut, where first hematopoietic cells arrive and expand. Hematopoietic cell migration occurs through cytokine stimulation, receptor expression, and glycosylation patterns on the cell surface. In addition, carbohydrates can modulate different cell activation states. For this reason, we aimed to characterize and quantify fetal megakaryocytic cells in mouse fetal liver according to their glycan residues at different gestational ages through lectins. Mouse fetuses between E11.5 and E18.5 were formalin-fixed and, paraffin-embedded, for immunofluorescence analysis using confocal microscopy. The results showed that the following sugar residues were expressed in proliferating and differentiating megakaryocytes in the fetal liver at different gestational ages: α-mannose, α-glucose, galactose, GlcNAc, and two types of complex oligosaccharides. Megakaryocytes also showed three proliferation waves during liver development at E12.5, E14.5, and E18.5. Additionally, the lectins that exhibited high and specific pattern intensities at liver capsules and vessels were shown to be a less time-consuming and robust alternative alternative to conventional antibodies for displaying liver structures such as capsules and vessels, as well as for megakaryocyte differentiation in the fetal liver.
Early Aptian marine incursions in the interior of northeastern Brazil following the Gondwana breakup
Authors: Fauth Gerson , Kern Henrique Parisi , Villegas-Martín Jorge , De Lira Mota Marcelo Augusto , dos Santos Filho Marcos Antonio Batista , Santa Catharina Amanda , Leandro Lilian Maia , Luft-Souza Fernanda , Strohschoen Oscar , Nauter-Alves Andressa , Tungo Edna de Jesus Francisco , Bruno Mauro Daniel Rodrigues , Ceolin Daiane , Baecker-Fauth Simone , Bom Marlone Heliara Hünnig , Lima Francisco Henrique de Oliveira , Santos Alessandra , Assine Mario Luis
Published: April 2023

This study reports a set of primeval marine incursions identified in two drill cores, 1PS-06-CE, and 1PS-10-CE, which recovered the Barbalha Formation, Araripe Basin, Brazil. Based on a multi-proxy approach involving stratigraphy, microbiofacies, ichnofossils, and microfossils, three short-lived marine incursions were identified, designated Araripe Marine Incursions (AMI) 1–3. AMI-1 and AMI-2, which occur within the shales of the Batateira Beds (lower part of the Barbalha Formation), were identified by the occurrence of benthonic foraminifera, calcareous nannofossils, dinocysts, and a mass mortality event of non-marine ostracods. AMI-3 was recognized in the upper part of the Barbalha Formation, based on the occurrence of ichnofossils and planktonic foraminifera. The observation of the planktonic foraminifera genus Leupoldina for the first time in the basin indicates early Aptian/early late Aptian age for these deposits, and the first opportunity of correlation with global foraminifera biozonation. Our findings have implications for the breakup of the Gondwana Supercontinent, as these incursions represent the earliest marine-derived flooding events in the inland basins of northeastern Brazil.
Detrusor underactivity is associated with metabolic syndrome in aged primates
Authors: Biscola Natalia P. , Bartmeyer Petra M. , Christe Kari L. , Colman Ricki J. , Havton Leif A.
Published: April 2023

Lower urinary tract (LUT) dysfunction is prevalent in the elderly population, and clinical manifestations include urinary retention, incontinence, and recurrent urinary tract infections. Age-associated LUT dysfunction is responsible for significant morbidity, compromised quality of life, and rising healthcare costs in older adults, but its pathophysiology is not well understood. We aimed to investigate the effects of aging on LUT function by urodynamic studies and metabolic markers in non-human primates. Adult (n = 27) and aged (n = 20) female rhesus macaques were evaluated by urodynamic and metabolic studies. Cystometry showed detrusor underactivity (DU) with increased bladder capacity and compliance in aged subjects. Metabolic syndrome indicators were present in the aged subjects, including increased weight, triglycerides, lactate dehydrogenase (LDH), alanine aminotransferase (ALT), and high sensitivity C-reactive protein (hsCRP), whereas aspartate aminotransferase (AST) was unaffected and the AST/ALT ratio reduced. Principal component analysis and paired correlations showed a strong association between DU and metabolic syndrome markers in aged primates with DU but not in aged primates without DU. The findings were unaffected by prior pregnancies, parity, and menopause. Our findings provide insights into possible mechanisms for age-associated DU and may guide new strategies to prevent and treat LUT dysfunction in older adults.
A multi-view contrastive learning for heterogeneous network embedding
Authors: Li Qi , Chen Wenping , Fang Zhaoxi , Ying Changtian , Wang Chen
Published: April 2023

Graph contrastive learning has been developed to learn discriminative node representations on homogeneous graphs. However, it is not clear how to augment the heterogeneous graphs without substantially altering the underlying semantics or how to design appropriate pretext tasks to fully capture the rich semantics preserved in heterogeneous information networks (HINs). Moreover, early investigations demonstrate that contrastive learning suffer from sampling bias, whereas conventional debiasing techniques (e.g., hard negative mining) are empirically shown to be inadequate for graph contrastive learning. How to mitigate the sampling bias on heterogeneous graphs is another important yet neglected problem. To address the aforementioned challenges, we propose a novel multi-view heterogeneous graph contrastive learning framework in this paper. We use metapaths, each of which depicts a complementary element of HINs, as the augmentation to generate multiple subgraphs (i.e., multi-views), and propose a novel pretext task to maximize the coherence between each pair of metapath-induced views. Furthermore, we employ a positive sampling strategy to explicitly select hard positives by jointly considering semantics and structures preserved on each metapath view to alleviate the sampling bias. Extensive experiments demonstrate MCL consistently outperforms state-of-the-art baselines on five real-world benchmark datasets and even its supervised counterparts in some settings.
Developing assessment flow for damage estimation of mud housing typology through a case study against coastal floods
Authors: Aishwarya N. , Aniruddha K. , Sutapa D. , Bharath H. A.
Published: April 2023

Rising instances of prolonged inundation due to climate-aggravated high tide flooding are economically burdensome for resource-crunched developing nations that bear enormous damage due to loss of built infrastructure (housing in this case). Regardless of the loss, coastal flood impact on buildings is rarely given precedence. The mud building typology in India captures 34% of existing housing demand primarily within ruralIndia; for instance, 75% of the housing in Sagar Island uses mud as the dominant construction material, making it an ideal case for the proposed research. The multivariate nature of damage and empirical data constraint associated with mud buildings propels the development of two unconventional damage assessment approaches using multivariate-probabilistic technique. The proposed literature-based approach uses logical reasoning based on the available scientific evidence whereas the lab-based approach uses the insights from structural analysis of scaled model. The damage matrix created from both the approaches are used to analyse a common flood data (depth & duration) generated using 1000 Montecarlo simulations. The resultant Damage Stage values confirm the versatility of either approach over spatial (local to regional)—temporal (flood character and intensity) dimensions. The lab-based approach proved to be a better alternative considering the availability of continuous records on damage behaviour and precise information on the flood threshold of dominant building material, a crucial component of the multivariate damage assessment process.
Corrosion inhibition of mild steel in hydrochloric acid solution by the expired Ampicillin drug
Authors: Alamry Khalid A. , Khan Ajahar , Aslam Jeenat , Hussein Mahmoud A. , Aslam Ruby
Published: April 2023

This study examines the utilization of the expired drug, namely ampicillin, as a mild steel corrosion inhibitor in an acidic environment. The inhibitor was evaluated using weight loss and electrochemical measurement accompanied with surface analytical techniques. The drug showed a potential inhibitory efficiency of > 95% at 55 °C. The inclusion of the inhibitor increased the charge transfer resistance at the steel-solution interface, according to impedance analyses. According to potentiodynamic polarisation measurements, expired ampicillin drug significantly decreased the corrosion current density and worked as a mixed-type corrosion inhibitor. The Langmuir adsorption isotherm was followed by the adsorption of ampicillin drug on the steel substrate, exhibiting an association of physical and chemical adsorption mechanisms. The surface study performed using contact angle and scanning electron microscopy–energy dispersive spectroscopy (SEM–EDS) measurements supported the inhibitor adsorption on the steel substrate.
Calcareous sponges can synthesize their skeleton under short-term ocean acidification
Authors: Ribeiro Bárbara , Lima Carolina , Pereira Sara Emilly , Peixoto Raquel , Klautau Michelle
Published: April 2023

Calcifying organisms are considered as threatened by ocean acidification, because of their calcium carbonate skeleton. This study investigated if a calcareous sponge could synthesize its skeleton (i.e. spicules) under ocean-acidification conditions. Sponge cell aggregates that have the potential to develop into a functional sponge, called primmorphs, were submitted to a 5-day experiment, with two treatments: control (pH 8.1) and acidified conditions (pH 7.6). Primmorphs of the calcareous sponge Paraleucilla magna were able to synthesize a skeleton, even under low pH, and to develop into functional sponges. The spicules had the same shape in both conditions, although the spicules synthesized in low pH were slightly thinner than those in the control. These results suggest that P. magna may be able to survive near-future ocean-acidification conditions.
The permeability of shale exposed to supercritical carbon dioxide
Authors: Wu Di , Zhai Wenbo , Liu Xueying , Xiao Xiaochun , Xu Jun , Jia Nan , Miao Feng
Published: April 2023

Permeability is a critical parameter of tight reservoir rocks and one of the important parameters for characterizing fluid flow and production from reservoirs. It determines the feasibility of its commercial development. SC-CO2 has been used in shale gas exploitation for efficient fracturing and the added benefit of CO2 geo-storage. And SC-CO2 plays an important role in permeability evolution of shale gas reservoirs. In this paper, Firstly, the permeability characteristics of shale under CO2 injection are discussed. The experimental results show that the relationship between permeability and gas pressure is not a single exponential relationship, but there is an obvious segmentation phenomenon, which is particularly obvious when it is close to the supercritical state, and the overall trend is first decreased and then increased. Subsequently, other specimens were selected for SC-CO2 immersion, and nitrogen was used to calibrate and compare shale permeability before and after treatment to assess changes in shale permeability after SC-CO2 treatment at pressures from 7.5 to 11.5 MPa and X-ray diffraction (XRD) analysis and scanning electron microscopy (SEM) were used to analyze the raw and CO2-treated shale particle sample, respectively. Results indicate the permeability increases significantly after SC-CO2 treated, and permeability growth is a linear function of SC-CO2 pressure. According to (XRD) analysis and (SEM) analysis, SC-CO2 not only can act as a solvent and dissolve carbonate minerals and clay minerals, but also can complex chemical reactions with mineral components in shale, Further dissolution of carbonate minerals and clay minerals, widened gas seepage channels and enhancing the permeability.
A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy
Authors: Meric Ilker , Alagoz Enver , Hysing Liv B. , Kögler Toni , Lathouwers Danny , Lionheart William R. B. , Mattingly John , Obhodas Jasmina , Pausch Guntram , Pettersen Helge E. S. , Ratliff Hunter N. , Rovituso Marta , Schellhammer Sonja M. , Setterdahl Lena M. , Skjerdal Kyrre , Sterpin Edmond , Sudac Davorin , Turko Joseph A. , Ytre-Hauge Kristian S. ,   The NOVO collaboration
Published: April 2023

Particle therapy (PT) used for cancer treatment can spare healthy tissue and reduce treatment toxicity. However, full exploitation of the dosimetric advantages of PT is not yet possible due to range uncertainties, warranting development of range-monitoring techniques. This study proposes a novel range-monitoring technique introducing the yet unexplored concept of simultaneous detection and imaging of fast neutrons and prompt-gamma rays produced in beam-tissue interactions. A quasi-monolithic organic detector array is proposed, and its feasibility for detecting range shifts in the context of proton therapy is explored through Monte Carlo simulations of realistic patient models and detector resolution effects. The results indicate that range shifts of$${1}\,\hbox {mm}$$1mmcan be detected at relatively low proton intensities ($$22.30(13)\times 10^{7}$$22.30(13)×107protons/spot) when spatial information obtained through imaging of both particle species are usedsimultaneously. This study lays the foundation formulti-particledetection and imaging systems in the context of range verification in PT.
Arntl deficiency in myeloid cells reduces neutrophil recruitment and delays skeletal muscle repair
Authors: Watanabe Aiko , Koike Hiroyuki , Kumagami Naoki , Shimba Shigeki , Manabe Ichiro , Oishi Yumiko
Published: April 2023

After a muscle injury, a process comprising inflammation, repair, and regeneration must occur in a time-sensitive manner for skeletal muscle to be adequately repaired and regenerated. This complex process is assumed to be controlled by various myeloid cell types, including monocytes and macrophages, though the mechanism is not fully understood. Aryl hydrocarbon receptor nuclear translocator-like (Arntl or Bmal1) is a transcription factor that controls the circadian rhythm and has been implicated in regulating myeloid cell functions. In the present study, we generated myeloid cell-specific Arntl conditional knockout (cKO) mice to assess the role of Arntl expressed in myeloid cell populations during the repair process after muscle injury. Myeloid cell-specific Arntl deletion impaired muscle regeneration after cardiotoxin injection. Flow cytometric analyses revealed that, in cKO mice, the numbers of infiltrating neutrophils and Ly6Chi monocytes within the injured site were reduced on days 1 and 2, respectively, after muscle injury. Moreover, neutrophil migration and the numbers of circulating monocytes were significantly reduced in cKO mice, which suggests these effects may account, at least in part, for the impaired regeneration. These findings suggest that Arntl, expressed in the myeloid lineage regulates neutrophil and monocyte recruitment and is therefore required for skeletal muscle regeneration.
Reduced efficiency of pelagic–benthic coupling in the Arctic deep sea during lower ice cover
Authors: Zhulay Irina , Iken Katrin , Renaud Paul E. , Kosobokova Ksenia , Bluhm Bodil A.
Published: April 2023

Pelagic–benthic coupling describes the connection between surface-water production and seafloor habitats via energy, nutrient and mass exchange. Massive ice loss and warming in the poorly studied Arctic Chukchi Borderland are hypothesized to affect this coupling. The strength of pelagic–benthic coupling was compared between 2 years varying in climate settings, 2005 and 2016, based on δ13C and δ15N stable isotopes of food-web end-members and pelagic and deep-sea benthic consumers. Considerably higher isotopic niche overlap and generally shorter isotopic distance were found between pelagic and benthic food web components in 2005 than in 2016, suggesting weaker coupling in the latter, low-ice year. δ15N values indicated more refractory food consumed by benthos in 2016 and fresher food reaching the seafloor in 2005. Higher δ13C values of zooplankton indirectly suggested a higher contribution of ice algae in 2005 than 2016. The difference in pelagic–benthic coupling between these years is consistent with higher energy retention within the pelagic system, perhaps due to strong stratification in the Amerasian Basin in the recent decade. Weaker coupling to the benthos can be expected to continue with ice loss in the study area, perhaps reducing benthic biomass and remineralization capacity; monitoring of the area is needed to confirm this prediction.
Characterization and investigation of biological properties of silver nanoparticle-doped hydroxyapatite-based surfaces on zirconium
Authors: Yildiz Tuba , Durdu Salih , Ozcan Kadriye , Usta Metin
Published: April 2023

The infections leading to failed implants can be controlled mainly by metal and metal oxide-based nanoparticles. In this work, the randomly distributed AgNPs-doped onto hydroxyapatite-based surfaces were produced on zirconium by micro arc oxidation (MAO) and electrochemical deposition processes. The surfaces were characterized by XRD, SEM, EDX mapping and EDX area and contact angle goniometer. AgNPs-doped MAO surfaces, which is beneficial for bone tissue growth exhibited hydrophilic behaviors. The bioactivity of the AgNPs-doped MAO surfaces is improved compared to bare Zr substrate under SBF conditions. Importantly, the AgNPs-doped MAO surfaces exhibited antimicrobial activity for E. coli and S. aureus compared to control samples.
Comparative chloroplast genome analysis of seven extant Citrullus species insight into genetic variation, phylogenetic relationships, and selective pressure
Authors: Zhou Cong , Wang Putao , Zeng Qun , Zeng Rongbin , Hu Wei , Sun Lei , Liu Shi , Luan Feishi , Zhu Qianglong
Published: April 2023

Citrullus ecirrhosus, Citrullus rehmii, and Citrullus naudinianus are three important related wild species of watermelon in the genus Citrullus, and their morphological differences are clear, however, their chloroplast genome differences remain unknown. This study is the first to assemble, analyze, and publish the complete chloroplast genomes of C. ecirrhosus, C. rehmii, and C. naudinianus. A comparative analysis was then conducted among the complete chloroplast genomes of seven extant Citrullus species, and the results demonstrated that the average genome sizes of Citrullus is 157,005 bp, a total of 130–133 annotated genes were identified, including 8 rRNA, 37 tRNA and 85–88 protein-encoding genes. Their gene content, order, and genome structure were similar. However, noncoding regions were more divergent than coding regions, and rps16-trnQ was a hypervariable fragment. Thirty-four polymorphic SSRs, 1,271 SNPs and 234 INDELs were identified. Phylogenetic trees revealed a clear phylogenetic relationship of Citrullus species, and the developed molecular markers (SNPs and rps16-trnQ) could be used for taxonomy in Citrullus. Three genes (atpB, clpP1, and rpoC2) were identified to undergo selection and would promote the environmental adaptation of Citrullus.
Different LED light spectra’s and nano-chelated potassium affect the quality traits of Dolce Vita cut roses in soilless culture condition
Authors: Heidari Zahra , Noruzi Parviz , Rezapour-fard Javad , Jabbarzadeh Zohreh
Published: April 2023

Roses are classified as neutral day plants, but high light and cool temperatures produce high quality flowers in roses. As light quantity, the light quality and its special spectra can affect the flower yield and quality. This research aimed to study of the effect of LED light (control (sunlight), blue and red spectra’s) and nano-chelated potassium at three levels (0, 1.5 and 3 g/l) on some morphophysiological and biochemical traits of Rosa hybrida cv. Dolce Vita. Light and nano-chelated potassium treatments have a significant effect on most traits measured in the present study. According to the results, the use of red light and nano-chelated potassium in rose cultivation improved the quality characteristics and increased vase life. The highest fresh and dry weight of flowering branch and plant height was observed in red light treatment and the concentration of 3 g/l nano-chelated potassium. Biochemical parameters such as phenolic compounds, leaf and petal flavonoids, petal anthocyanin content, antioxidant capacity and vase life were also significantly increased under red light and with the concentration of 3 g/l nano-chelated potassium compared to the control. In general, it can be said that the use of red light and a concentration of 3 g/l nano-chelated potassium, can be effective in improving the quality of rose flowers, especially in low light condition.
Genomic footprints of bottleneck in landlocked salmon population
Authors: Subramanian Sankar , Kumar Manoharan
Published: April 2023

At the end of the last ice age, several Atlantic salmon populations got caught up in the lakes and ponds of the Northern Hemisphere. Occasionally, the populations also got locked when the flow of rivers terminated from reaching the sea due to land upheaval. Therefore, the pattern of evolution shaping the landlocked salmon populations is different from the other anadromous salmons, which migrate between the sea and rivers. According to the theories of population genetics, the effect of genetic drift is expected to be more pronounced in the former compared to the latter. Here we examined this using the whole genome data of landlocked and anadromous salmon populations of Norway. Our results showed a 50–80% reduction in the genomic heterozygosity in the landlocked compared to anadromous salmon populations. The number and total size of the runs of homozygosity (RoH) segments of landlocked salmons were two to eightfold higher than those of their anadromous counterparts. We found the former had a higher ratio of nonsynonymous-to-synonymous diversities than the latter. The investigation also revealed a significant elevation of homozygous deleterious Single Nucleotide Variants (SNVs) in the landlocked salmon compared to the anadromous populations. All these results point to a significant reduction in the population size of the landlocked salmons. This process of reduction might have started recently as the phylogeny revealed a recent separation of the landlocked from the anadromous population. Previous studies on terrestrial vertebrates observed similar signatures of a bottleneck when the populations from Island and the mainland were compared. Since landlocked waterbody such as ponds and lakes are geographically analogous to Islands for fish populations, the findings of this study suggest the similarity in the patterns of evolution between the two.
Vibrational properties of metastable orthorhombic Bi2Se3
Authors: Souza Paloma B. , Tumelero Milton A. , Faccio Ricardo , Ahmed Rasin , Plá Cid Cristiani C. , Zangari Giovanni , Pasa Andre A.
Published: April 2023

The orthorhombic Bi2Se3 is a chalcogenide material considered a promising system for energy harvesting and energy conversion. Here we studied its vibrational and structural properties.
Biocompatible metallosurfactant-based nanocolloid-loaded Rose Bengal with excellent singlet oxygen-induced phototoxicity efficiency against cancer cells
Authors: Sharma Bunty , Jain Akhil , Rawson Frankie J. , Chaudhary Ganga Ram , Pérez-García Lluïsa , Kaur Gurpreet
Published: April 2023

Dual-charge, stable, and biocompatible metallocatanionic vesicles as a promising delivery vehicle for Rose Bengal that can enhance the singlet oxygen generation and phototoxicity effect against U-251 cancer cells.
A voltammetric sensor based on a reduced graphene oxide/β-cyclodextrin/silver nanoparticle/polyoxometalate nanocomposite for detecting uric acid and tyrosine
Authors: Chai Xu , Li Yongbiao , Ma Chaonan , Guo Minjie , Fan Zhi , Zhao Jin , Cheng Bowen
Published: April 2023

An electrochemical sensor based on a reduced graphene oxide/β-cyclodextrin/silver nanoparticle/polyoxometalate nanocomposite for the simultaneous detection of uric acid and tyrosine.
A novel fluorescent nanoprobe for sensitive detection of 6-thioguanine in human serum based on Cu/Ag nanoclusters
Authors: Chen Wenjing , Hu Dongbao , Yang Meng , Zhu Yi , Wu Yunying , Li Xi , Zhang Juntong , Yang Jiqiu , Huang Yan , Xie Jianxin
Published: April 2023

A highly sensitive, selective and rapid fluorescent nanoprobe for the detection of a purine analog anticancer drug 6-thioguanine (6-TG) based on Cu/Ag nanoclusters with a wide linear concentration range from 2.5 to 100 μM and a limit of detection of 1.57 μM was developed.
A ratiometric fluorescence sensor based on gold silver nanoclusters and tungsten disulfide quantum dots with simple fabrication for the detection of copper ions in river water
Authors: Wang Zhiya , Liu Rong , Fu Zhifang , Yi Xin , Hu Yongjun , Liu Changhui , Pan Dong , Wu Zhaoyang
Published: April 2023

This sensor was used to detect the concentration of Cu2+ ions in lake water with satisfactory results. The nanosensor was developed by using a simple mixture of AuNCs and WS2-QDs without necessary fabrication of silica microspheres.
A facile theragnostic nano-platform for the effective treatment and real-time imaging of acute liver injury
Authors: Li Huixin , Hao Kai , Wu Jiayan , He Chaoliang , He Shasha , Tian Huayu , Chen Xuesi
Published: April 2023

A facile nanoplatform loaded with dexamethasone sodium phosphate and protease responsive probe realizes liver targeting, acute liver injury treatment and real-time imaging.
Ultrasound-enhanced theranostics of orthotopic breast cancer through a multifunctional core–shell tecto dendrimer-based nanomedicine platform
Authors: Gong Junli , Song Cong , Li Gaoming , Guo Yunqi , Wang Zhiqiang , Guo Honghua , Xia Jindong , Tao Yuchen , Shi Qiusheng , Shi Xiangyang , Shen Mingwu
Published: April 2023

Design of a multifunctional nanoplatform combined with ultrasound-targeted microbubble destruction (UTMD) technology for enhanced tumor accumulation is feasible to solve the bottleneck of theranostics.
Co-electrocatalytic CO2reduction mediated by a dibenzophosphole oxide and a chromium complex
Authors: Koellner Connor A. , Reid Amelia G. , Machan Charles W.
Published: April 2023

A dibenzophosphole oxide is intrinsically inactive for electrocatalytic CO2reduction, however, when combined with a Cr complex it can coordinate in a reduced state, facilitating electron transfer and improving activity.
Visible light photoredox-catalyzed arylative cyclization to access benzimidazo[2,1-a]isoquinolin-6(5H)-ones
Authors: Meher Prahallad , Samanta Raj Kumar , Manna Sourav , Murarka Sandip
Published: April 2023

An efficient Ru(ii)-photoredox-catalyzed radical cascade between N-substituted 2-arylbenzoimidazoles and diaryliodonium triflates furnishing a variety of arylated-benzimidazo[2,1-a]isoquinolin-6(5H)-ones is achieved.
Reduction of 2-H-substituted pyrrolinium cations: the carbon–carbon single bond in air stable 2,2′-bipyrrolidines as a two-electron-source
Authors: Nayak Mithilesh Kumar , Elvers Benedict J. , Mandal Debdeep , Das Ayan , Ramakrishnan Raghunathan , Mote Kaustubh R. , Schulzke Carola , Yildiz Cem Burak , Jana Anukul
Published: April 2023

2-Substituted pyrrolinium cations are reduced to air and moisture stable 2,2′-bipyrrolidines − the newly formed carbon–carbon single bond is electron-rich and may be utilized as an organic electron donor for various chemical transformations.
Catalytic conversion of chitin as a nitrogen-containing biomass
Authors: Kobayashi Hirokazu , Sagawa Takuya , Fukuoka Atsushi
Published: April 2023

The efficient catalytic conversion of chitin enables the material cycle through natural carbon and nitrogen fixation.
Formation of covalent metal–carbon contacts assisted by Ag+ for single molecule junctions
Authors: Song Kai , Lin Junfeng , Song Xuwei , Yang Bowen , Zhu Jia , Zang Yaping , Zhu Daoben
Published: April 2023

We develop a metal ion-assisted method to create covalent metal–carbon (M–C) bonds for molecular junctions.
Cation and anion optimization of ammonium halide for interfacial passivation of inverted perovskite solar cells
Authors: Wu Hao , Yin Xinxing , Lu Lei , Song Jiaxing , Hu Lin , Jin Yingzhi , Su Zhen , Hai Jiefeng , Li Zaifang
Published: April 2023

The effect of passivation and the underlying mechanism were investigated by an in-depth study of 2-(phenylamino)ethane-1-amine salts (PNEA+) with different halide anions. The inverted PSC based on PNEACl provided a champion PCE of 21%.
Efficient arsenic coagulation by serpentine-mediated iron hydroxides
Authors: Ouyang Lei , Song Fangfang , Yu Caiyue , Huang Lijin , Shuai Qin
Published: April 2023

As(iii) and As(v) can be efficiently coagulated by serpentine-mediated active iron hydroxides. The pH-buffering function of serpentine and the chemical affinity between Fe–As and Mg–As contribute to the arsenic coagulation.
Total synthesis and structural reassignment of garcinielliptone FC, a polycyclic polyprenylated acylphloroglucinol with diverse bioactivity
Authors: Luo Yang , Grossman Robert B. , Nie Xiao-Bin , Yang Xing-Wei
Published: April 2023

Garcinielliptone FC was assigned to be a type A polycyclic polyprenylated acylphloroglucinol (PPAP) and was found to exhibit diverse biological activities. We revise its structure to xanthochymol, a type B PPAP, via NMR and total synthesis methods.
Superhelicenes in the gas phase: experimental and computational evidence of stable radical cation dimers
Authors: Kinzelmann Marina , Reger David , Warmbrunn Vera , Lungerich Dominik , Jux Norbert , Drewello Thomas
Published: April 2023

Stable radical cation π-dimers of superhelicenes are produced by ESI-MS. Dissociation into two singly charged ions is investigated using energy-resolved collision experiments. DFT calculations show the preferred formation of the open-shell dication.
Overview of the oxygen vacancy effect in bimetallic spinel and perovskite oxide electrode materials for high-performance supercapacitors
Authors: Khaja Hussain Sk. , Bang Jin Ho
Published: April 2023

This article reviews synthesis strategies for the generation of oxygen vacancies in spinel and perovskite electrodes and discusses the consequences and outlook for supercapacitors.
Probing the general base for DNA polymerization in telomerase: a molecular dynamics investigation
Authors: Das Chandan Kumar , Gupta Abhinav , Nair Nisanth N.
Published: April 2023

This computational study finds that during the DNA polymerization in telomerase, Mg coordinated Asp344 and active site water molecules act as the general composite base.
Frictional properties of MoS2 on a multi-level rough wall under starved lubrication
Authors: Yi Changli , Hu Chengzhi , Shi Lin , Bai Minli , Li Yubai , Tang Dawei
Published: April 2023

MoS2 exhibited excellent bearing capacity, and a large-area of MoS2 coated on the asperity surface could effectively prevent asperity contact, reduce friction coefficient and wear.
A Maxwell relation for dynamical timescales with application to the pressure and temperature dependence of water self-diffusion and shear viscosity
Authors: Piskulich Zeke A. , Borkowski Ashley K. , Thompson Ward H.
Published: April 2023

A Maxwell relation for dynamical timescales motivates a physically meaningful description of the timescale over broad pressure and temperature ranges.
Silicon(iv) complexes of octaaryl-substituted porphyrazines and corrolazines: influence of macrocycle contraction on spectral-luminescence, acid–base, and redox properties
Authors: Rychikhina Ekaterina D. , Ivanova Svetlana S. , Novakova Veronika , Stuzhin Pavel A.
Published: April 2023

Octaaryl-substituted Si(iv) corrolazine complexes, obtained by reductive ring contraction reaction of the appropriate SiPzAr8, exhibit high ability for single oxygen generation. The crucial role of acid in the Pz → Cz transformation is revealed.
Bio-inspired design of NiFeP nanoparticles embedded in (N,P) co-doped carbon for boosting overall water splitting
Authors: Zhang Xiangrui , Shi Xue-Rong , Wang Peijie , Bao Zhiyu , Huang Mengru , Xu Yanan , Xu Shusheng
Published: April 2023

Inspired by natural biomass mineralization, we synthesized CNTs-modified NiFeP embedded in N and P co-doped porous carbon materials using N-containing sugar (chitosan), biomass P source (phytic acid), metal salts, and CNTs as raw materials.
Silver-based coordination polymers assembled by dithioether ligands: potential antibacterial materials despite received ideas
Authors: Gaudillat Quentin , Krupp Anna , Zwingelstein Thibaut , Humblot Vincent , Strohmann Carsten , Jourdain Isabelle , Knorr Michael , Viau Lydie
Published: April 2023

Two-dimensional coordination polymers (CPs) assembled by soft dithioether ligands and soft Lewis acid Ag(i) present different antibacterial properties depending on the coordination mode of the sulphur atoms.
Static in vitro digestion model adapted to the general older adult population: an INFOGEST international consensus
Authors: Menard O. , Lesmes U. , Shani-Levi C. S. , Araiza Calahorra A. , Lavoisier A. , Morzel M. , Rieder A. , Feron G. , Nebbia S. , Mashiah L. , Andres A. , Bornhorst G. , Carrière F. , Egger L. , Gwala S. , Heredia A. , Kirkhus B. , Macierzanka A. , Portman R. , Recio I. , Santé-Lhoutellier V. , Tournier C. , Sarkar A. , Brodkorb A. , Mackie A. , Dupont D.
Published: April 2023

Physiological parameters of the static in vitro digestion model adapted to the general older adult.
Recent advances in interface engineering of Fe/Co/Ni-based heterostructure electrocatalysts for water splitting
Authors: Hao Ju , Wu Kaili , Lyu Chaojie , Yang Yuquan , Wu Hongjing , Liu Jiajia , Liu Naiyan , Lau Woon-Ming , Zheng Jinlong
Published: April 2023

The application and prospect of Fe/Co/Ni-based catalysts modified by interface engineering, and biomass electrooxidation reaction (BEOR) coupled with hydrogen evolution reaction (HER) in water splitting are summarized.
Electronic, optical, and transport properties of single-layer ZrTeS4: a DFT study
Authors: Vo Dat D. , Vu Tuan V. , Lavrentyev A. A. , Khyzhun O. Y. , Kartamyshev A. I. , Tong Hien D. , Hieu Nguyen N.
Published: April 2023

ZrTeS4 is a promising photoelectric semiconductor with a tunable band gap and high ultra-violet absorption rate.
Theoretical investigation on the atmospheric degradation mechanism, kinetics, and fate of hydroxymethyl nitrate initiated by ˙OH radicals
Authors: Liu Xiang-Huan , Meng Ting-Ting , Bai Feng-Yang , Ni Shuang , Zhao Zhen
Published: April 2023

New insights into the ˙OH-initiated degradation mechanism, kinetics, and fate of hydroxymethyl nitrate have been investigated for the first time.
A simple and efficient transfer method for fabricating stretchable AgNW patterns on PDMS using carboxylated cellulose nanofibers as a sacrificial layer
Authors: Wang Jianzhong , Wang Kaiqing , Xiao Fei
Published: April 2023

A facile method of complete transfer of AgNW networks was developed to fabricate high-performance stretchable AgNW patterns on PDMS using water-soluble carboxylated cellulose nanofibers as a sacrificial adhesion-manipulating layer.
Sulfidation and NaOH etching in CoFeAl LDH evolved catalysts for an efficient overall water splitting in an alkaline solution
Authors: Deng Xiaolong , Wang Shanshan , Liu Yi , Cao Jiafeng , Huang Jinzhao , Shi Xingwei
Published: April 2023

The sequence of sulfidation and NaOH etching plays an important role in the morphological structure of CoFeAl LDH evolved catalysts and thus results in a completely different water splitting activity in an alkaline solution.
Advances in functional organic material-based interfacial engineering on metal anodes for rechargeable secondary batteries
Authors: Shi Ruijuan , Shen Zhen , Yue Qianqian , Zhao Yong
Published: April 2023

Functional organic materials with structural designability and sustainability offer an attractive solution to promote the interfacial engineering on metal anodes, including SEI modification, 3D skeleton construction, and gel/solid-state electrolytes.
The new synthesis of pyrrole-fused dibenzo[b,f][1,4]oxazepine/thiazepines by the pseudo-Joullié–Ugi reactionviaan unexpected route with high chemoselectivity
Authors: Nazeri Mohammad Taghi , Ahmadi Masoomeh , Ghasemi Maryam , Shaabani Ahmad , Notash Behrouz
Published: April 2023

We report an unexpected route for synthesizing pyrrole-fused dibenzoxazepines/thiazepines with high chemoselectivityviaa pseudo-Joullié–Ugi reaction from cyclic imines with isocyanides and acetylenedicarboxylates under catalyst-free conditions.
Solid state chemical transformation provides a fully benzoxazine-linked porous organic polymer displaying enhanced CO2 capture and supercapacitor performance
Authors: Ejaz Mohsin , Mohamed Mohamed Gamal , Kuo Shiao-Wei
Published: April 2023

We synthesized a fully benzoxazine (BZ)-linked POP comprising TPA and DHPT units through Sonogashira–Hagihara coupling and ring opening polymerization for CO2 capture and energy storage.
Metallic TiN nanoparticles loaded on g-C3N4 for plasmon enhanced visible and NIR photocatalytic H2 evolution from water splitting
Authors: Ullah Ikram , Ling Cong , Li Jing-Han , Lu Xiao-Jie , Yang Zhengkun , Wang Gang , Xu An-Wu
Published: April 2023

The plasmonic effect of metallic TiN nanoparticles has been studied to promote, charge transport and separation over plasmonic CN/TiN photocatalysts, resulting in plasmon enhanced visible and NIR photocatalytic H2 production from water splitting.
Recent advances in the electrochemical generation of 1,3-dicarbonyl radicals from C–H bonds
Authors: Wan Qinhui , Zhang Zhongyi , Hou Zhong-Wei , Wang Lei
Published: April 2023

Recent advances in the electrochemical generation of 1,3-dicarbonyl radicals from C–H bonds and their mechanistic insights and synthetic applications have been summarized.
Multicomponent oxide microspheres with designed macroporosity (MICROSCAFS®): a customized platform for chemicals immobilization
Authors: Vale Mário , Orišková Sofia , Mariquito António , Reis Luís , Pinto Moisés , Marques Ana C.
Published: April 2023

We control phase separation/gelation inside of emulsion droplets to reproducibly achieve SiO2–TiO2 based microspheres with tailored interconnected coral-like macroporosity. These microspheres (MICROSCAFS®) are key enablers of emergent applications.
The mechanism of water pollutant photodegradation by mixed and core–shell WO3/TiO2nanocomposites
Authors: Habtamu Abdisa , Ujihara Masaki
Published: April 2023

Mixed and core–shell WO3/TiO2exhibited different photocatalytic activities due to their surface charges and charge separation behaviors.
Diversity-oriented synthesis of medium-sized cyclophanes via the photo-fries rearrangement of N-aryl lactams
Authors: Szcześniak Piotr , Furman Bartłomiej
Published: April 2023

A comprehensive and sustainable protocol for the preparation of structurally diverse ortho- and para-cyclophanes via a light-promoted Fries-type intramolecular rearrangement of N-aryl lactams is presented.
Self-assembly of a fluorescent virus-like particle for imaging in tissues with high autofluorescence
Authors: Trashi Ikeda , Durbacz Mateusz Z. , Trashi Orikeda , Wijesundara Yalini H. , Ehrman Ryanne N. , Chiev Alyssa C. , Darwin Cary B. , Herbert Fabian C. , Gadhvi Jashkaran , De Nisco Nicole J. , Nielsen Steven O. , Gassensmith Jeremiah J.
Published: April 2023

Qβ VLP simplified assembly approach uses the positively charged Rev tag to interact electrostatically with the negatively charged RNAs. This system exploits the known hairpins produced in the coat protein sequence to template the assembly of the full viral capsid.
Defect-induced photogating effect and its modulation in ultrathin free-standing Bi2O2Se nanosheets with a visible-to-near-infrared photoresponse
Authors: Hossain Md Tarik , Jena Tadasha , Debnath Subhankar , Giri P. K.
Published: April 2023

Defect induced persistent negative photoconductivity in free-standing Bi2O2Se nanosheets and its modulation with vacuum annealing.
An optimization strategy for enhancing energy consumption performance in digital currency miner's building
Authors: Akbarnavasi Hossein , Ledari Masoumeh Bararzadeh , Ghadertootoonchi Alireza
Published: April 2023

Cryptocurrencies, as a way of extraction, are categorized into two main groups of non‐mineable and mineable. Bitcoin, the most famous mineable digital currency, utilizes the Proof of Work (PoW) algorithm for maintaining network solidarity. Its mining process is done by devices known as application specific integrated circuits, which consume electricity and turn it into heat. They shall operate within an accepted temperature range of around 25°C; otherwise, they will face an efficiency drop; consequently, all mining sites require a proper cooling system. This study aims to investigate the problem of high energy consumption for cooling in digital currency mining sites and to present a solution for that via optimizing the capacity and operation of the chiller and ice thermal storage system (ITS). The results show the utilization of the ITS system reduces the operational costs by 10%, and the ITS system provides 1320 kWh of cooling energy during peak hours. Finally, the sensitivity analysis results considering the impact of the electricity tariff on the size and operation of the system have confirmed that with an increase in peak time tariff, the role of the ITS system in cost reduction increases.
Reshaping the tourist movement in historical urban areas for enhancing architecture conservation: Historical district of Koya city as a case study
Authors: Baiz Zhiry Hawez , Atakara Cemil
Published: April 2023

Architectural strategy in the conservation field should be on both levels, tangible and intangible. The conservation of the non‐tangible part includes signs and symbols. It transmits in various ways, like oral, artistic, and literary forms of expression. The visitor of historical places can participate in non‐tangible conservation if the architect makes the visitor attracted to the sites. To make the visitor see the values of the sites, the visitor should move to different parts in different directions instead of seeing a few buildings and monuments. The study aims to increase visitor activity to promote non‐physical conservation. Many places like Koya city have a very high architectural value but it is still neglected and uncovered by visitors. Researchers made observations to demonstrate the general characteristics of the district, then designed a questionnaire to collect the required data, specifying the locations they mostly visit, determining the paths they have taken, defining the areas visitors rarely visit, and alleys they do not go through for various reasons, gradually becoming a neglected place. Finally, the study conducted space syntax analysis based on pedestrian movement to reshape the visitor's movement. Based on the findings, the study will design strategies to enhance tourist movement and conserve non‐tangibles.
The CORALIE survey for southern extrasolar planets
Authors: Barbato D. , Ségransan D. , Udry S. , Unger N. , Bouchy F. , Lovis C. , Mayor M. , Pepe F. , Queloz D. , Santos N. C. , Delisle J. B. , Figueira P. , Marmier M. , Matthews E. C. , Lo Curto G. , Venturini J. , Chaverot G. , Cretignier M. , Otegi J. F. , Stalport M.
Published: April 2023

Context. A historical search for exoplanets among a sample of 1647 nearby southern main sequence stars with the CORALIE spectrograph at La Silla Observatory has been underway since 1998, with a backup subprogram dedicated to the monitoring of binary stars.

Aims. We reviewed 25 years of CORALIE measurements and search for Doppler signals consistent with stellar or brown dwarf companions to produce an updated catalog of both known and previously unpublished binary stars in the planet-search sample. We assessed the binarity fraction of the stellar population and survey the prospects for more precise searches for planets in the binary sample.

Methods. We performed a new analysis on the CORALIE planet-search sample’s radial velocity measurements, searching for stellar companions and obtaining orbital solutions for both known and new binary systems. We performed simultaneous radial velocity and proper motion anomaly fits on the subset of these systems for which HIPPARCOS and Gaia astrometry measurements are available, obtaining accurate estimates of true mass for the companions.

Results. We found 218 stars in the CORALIE sample to have at least one stellar companion, 130 of which are not yet published in the literature and for which we present orbital solutions. The use of the proper motion anomaly allowed us to derive true masses for the stellar companions in 132 systems, which we additionally used to estimate stability regions for possible planetary companions on circumprimary or circumbinary orbits. Finally, we produced detection-limit maps for each star in the sample and obtained occurrence rates of 0.43−0.11+0.23% and 12.69−0.77+0.87% for brown dwarf and stellar companions, respectively, in the CORALIE sample.