bluuebunny/crossref_metadata_2025 huggingface dataset:
A Platform and Its Applied Modes for Geography Fieldwork in Higher Education Based on Location Services
Authors: Ruan Ling , Long Yi , Zhang Ling , Lv Guonian
Published: April 2021

Fieldwork is an important aspect of geography learning in higher educational institutions. Under the support of mobile technologies, the process and method of fieldwork in geography education have significantly been changed. However, the in-depth combination of Location-Based Services (LBSs) and geography fieldwork is still in the initial exploration stage. This paper designed and implemented a professional geography fieldwork platform based on Lushan, a famous geography fieldwork education station in Jiangxi, China. The platform includes the student-side mobile application, teacher-side mobile application, and a web back-end management system. Three specific technologically-enhanced applied modes were put forward based on the platform, which contains teacher-centered, semi-supervised, and student-independent modes. Students’ views on the three applied modes and usage in the fieldwork platform were collected through a questionnaire. The result shows that the LBS fieldwork platform has significant support for geography fieldwork. It meets the needs of students and reduces the burden for teachers. The teacher-centered is the most popular mode for students. Due to the unguaranteed fieldwork safety, inconvenient dynamic adjustment, and the habit of relying on the teacher’s explanation, the student-independent mode based on the LBS platform has apparent limitations. Nevertheless, students can recognize its potential in improving their practical, cooperative, and autonomous abilities. They are willing to try independent fieldwork supported by the platform in several days.
Thirty-Year Dynamics of LULC at the Dong Thap Muoi Area, Southern Vietnam, Using Google Earth Engine
Authors: Binh Nguyen An , Nhut Huynh Song , An Nguyen Ngoc , Phuong Tran Anh , Hanh Nguyen Cao , Thao Giang Thi Phuong , Pham The Trinh , Hong Pham Viet , Ha Le Thi Thu , Bui Dieu Tien , Hoa Pham Viet
Published: April 2021

The main purpose of this paper is to assess the land use and land cover (LULC) changes for thirty years, from 1990–2020, in the Dong Thap Muoi, a flooded land area of the Mekong River Delta of Vietnam using Google Earth Engine and random forest algorithm. The specific purposes are: (1) determine the main LULC classes and (2) compute and analyze the magnitude and rate of changes for these LULC classes. For the above purposes, 128 Landsat images, topographic maps, land use status maps, cadastral maps, and ancillary data were collected and utilized to derive the LULC maps using the random forest classification algorithm. The overall accuracy of the LULC maps for 1990, 2000, 2010, and 2020 are 88.9, 83.5, 87.1, and 85.6%, respectively. The result showed that the unused land was dominant in 1990 with 28.9 % of the total area, but it was primarily converted to the paddy, a new dominant LULC class in 2020 (45.1%). The forest was reduced significantly from 14.4% in 1990 to only 5.5% of the total area in 2020. Whereas at the same time, the built-up increased from 0.3% to 6.2% of the total area. This research may help the authorities design exploitation policies for the Dong Thap Muoi’s socio-economic development and develop a new, stable, and sustainable ecosystem, promoting the advantages of the region, early forming a diversified agricultural structure.
Urban Fine-Grained Spatial Structure Detection Based on a New Traffic Flow Interaction Analysis Framework
Authors: Zhang Yan , Zheng Xiang , Chen Min , Li Yingbing , Yan Yingxue , Wang Peiying
Published: April 2021

The urban structure is the spatial reflection of various economic and cultural factors acting on the urban territory. Different from the physical structure, urban structure is closely related to the population mobility. Taxi trajectories are widely distributed, completely spontaneous, closely related to travel needs, and massive in data volume. Mining it not only can help us better understand the flow pattern of a city, but also provides a new perspective for interpreting the urban structure. On the basis of massive taxi trajectory data in Chengdu, we introduce a network science approach to analysis, propose a new framework for interaction analysis, and model the intrinsic connections within cities. The spatial grid of fine particles and the trajectory connections between them are used to resolve the urban structure. The results show that: (1) Based on 200,000 taxi trajectories, we constructed a spatial network of traffic flow using the interaction analysis framework and extracted the cold hot spots among them. (2) We divide the 400 traffic flow network nodes into 6 communities. Community 2 has high centrality and density, and belongs to the core built-up area of the city. (3) A traffic direction field is proposed to describe the direction of the traffic flow network, and the direction of traffic flow roughly presents an inflow from northeast to southwest and an outflow from southeast to northwest of the study area. The interaction analysis framework proposed in this study can be applied to other cities or other research areas (e.g., population migration), and it could extract the directional nature of the network as well as the hierarchical structure of the city.
View-Dependent Progressive Transmission Method for 3D Building Models
Authors: Sun Yuchang , Ma Jingsong , She Jiangfeng , Zhao Qiang , He Lixia
Published: April 2021

Complex 3D building models, because of their huge data volume, almost always result in transmission congestion, which leads to poor user experience. To reduce the real-time transmission pressure, a novel view-dependent progressive transmission method was developed. With this method, only a small amount of transmitted data is necessary to achieve an acceptable rendering effect when the viewpoint changes. The method involves two stages. A preprocessing stage simplifies the building model using a multi-level vertex clustering algorithm. The local mesh in each clustering unit is organized into a node tree where each node includes a vertex and its related triangles. The building model is finally reorganized into a node forest. In the reconstruction stage, all root nodes are transmitted first to build a basic model. Their descendant nodes are then requested and transmitted according to viewpoint information to refine the building model during user interaction. The experimental results show that this method can effectively improve the transmission and reconstruction efficiency of 3D building models.
Parking Places to Moped-Style Scooter Sharing Services Using GIS Location-Allocation Models and GPS Data
Authors: Pérez-Fernández Onel , García-Palomares Juan Carlos
Published: April 2021

Moped-style scooters are one of the most popular systems of micro-mobility. They are undoubtedly good for the city, as they promote forms of environmentally-friendly mobility, in which flexibility helps prevent traffic build-up in the urban centers where they operate. However, their increasing numbers are also generating conflicts as a result of the bad behavior of users, their unwarranted use in public spaces, and above all their parking. This paper proposes a methodology for finding parking spaces for shared motorcycle services using Geographic information system (GIS) location-allocation models and Global Positioning System (GPS) data. We used the center of Madrid and data from the company Muving (one of the city’s main operators) for our case study. As well as finding the location of parking spaces for motorbikes, our analysis examines how the varying distribution of demand over the course of the day affects the demand allocated to parking spaces. The results demonstrate how reserving a relatively small number of parking spaces for scooters makes it possible to capture over 70% of journeys in the catchment area. The daily variations in the distribution of demand slightly reduce the efficiency of the network of parking spaces in the morning and increase it at night, when demand is strongly focused on the most central areas.
Characterization of the mbsA Gene Encoding a Putative APSES Transcription Factor in Aspergillus fumigatus
Authors: Choi Yong-Ho , Jun Sang-Cheol , Lee Min-Woo , Yu Jae-Hyuk , Shin Kwang-Soo
Published: April 2021

The APSES family proteins are transcription factors (TFs) with a basic helix-loop-helix domain, known to regulate growth, development, secondary metabolism, and other biological processes in Aspergillus species. In the genome of the human opportunistic pathogenic fungus Aspergillus fumigatus, five genes predicted to encode APSES TFs are present. Here, we report the characterization of one of these genes, called mbsA (Afu7g05620). The deletion (Δ) of mbsA resulted in significantly decreased hyphal growth and asexual sporulation (conidiation), and lowered mRNA levels of the key conidiation genes abaA, brlA, and wetA. Moreover, ΔmbsA resulted in reduced spore germination rates, elevated sensitivity toward Nikkomycin Z, and significantly lowered transcripts levels of genes associated with chitin synthesis. The mbsA deletion also resulted in significantly reduced levels of proteins and transcripts of genes associated with the SakA MAP kinase pathway. Importantly, the cell wall hydrophobicity and architecture of the ΔmbsA asexual spores (conidia) were altered, notably lacking the rodlet layer on the surface of the ΔmbsA conidium. Comparative transcriptomic analyses revealed that the ΔmbsA mutant showed higher mRNA levels of gliotoxin (GT) biosynthetic genes, which was corroborated by elevated levels of GT production in the mutant. While the ΔmbsA mutant produced higher amount of GT, ΔmbsA strains showed reduced virulence in the murine model, likely due to the defective spore integrity. In summary, the putative APSES TF MbsA plays a multiple role in governing growth, development, spore wall architecture, GT production, and virulence, which may be associated with the attenuated SakA signaling pathway.
Endogenous Opioid Peptides and Alternatively Spliced Mu Opioid Receptor Seven Transmembrane Carboxyl-Terminal Variants
Authors: Abrimian Anna , Kraft Tamar , Pan Ying-Xian
Published: April 2021

There exist three main types of endogenous opioid peptides, enkephalins, dynorphins and β-endorphin, all of which are derived from their precursors. These endogenous opioid peptides act through opioid receptors, including mu opioid receptor (MOR), delta opioid receptor (DOR) and kappa opioid receptor (KOR), and play important roles not only in analgesia, but also many other biological processes such as reward, stress response, feeding and emotion. The MOR gene, OPRM1, undergoes extensive alternative pre-mRNA splicing, generating multiple splice variants or isoforms. One type of these splice variants, the full-length 7 transmembrane (TM) Carboxyl (C)-terminal variants, has the same receptor structures but contains different intracellular C-terminal tails. The pharmacological functions of several endogenous opioid peptides through the mouse, rat and human OPRM1 7TM C-terminal variants have been considerably investigated together with various mu opioid ligands. The current review focuses on the studies of these endogenous opioid peptides and summarizes the results from early pharmacological studies, including receptor binding affinity and G protein activation, and recent studies of β-arrestin2 recruitment and biased signaling, aiming to provide new insights into the mechanisms and functions of endogenous opioid peptides, which are mediated through the OPRM1 7TM C-terminal splice variants.
Chronic Low Grade Inflammation in Pathogenesis of PCOS
Authors: Rudnicka Ewa , Suchta Katarzyna , Grymowicz Monika , Calik-Ksepka Anna , Smolarczyk Katarzyna , Duszewska Anna M. , Smolarczyk Roman , Meczekalski Blazej
Published: April 2021

Polycystic ovary syndrome (PCOS) is a one of the most common endocrine disorders, with a prevalence rate of 5–10% in reproductive aged women. It’s characterized by (1) chronic anovulation, (2) biochemical and/or clinical hyperandrogenism, and (3) polycystic ovarian morphology. PCOS has significant clinical implications and can lead to health problems related to the accumulation of adipose tissue, such as obesity, insulin resistance, metabolic syndrome, and type 2 diabetes. There is also evidence that PCOS patients are at higher risk of cardiovascular diseases, atherosclerosis, and high blood pressure. Several studies have reported the association between polycystic ovary syndrome (PCOS) and low-grade chronic inflammation. According to known data, inflammatory markers or their gene markers are higher in PCOS patients. Correlations have been found between increased levels of C-reactive protein (CRP), interleukin 18 (IL-18), tumor necrosis factor (TNF-α), interleukin 6 (IL-6), white blood cell count (WBC), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1α (MIP-1α) in the PCOS women compared with age- and BMI-matched controls. Women with PCOS present also elevated levels of AGEs and increased RAGE (receptor for advanced glycation end products) expression. This chronic inflammatory state is aggravating by obesity and hyperinsulinemia. There are studies describing mutual impact of hyperinsulinemia and obesity, hyperandrogenism, and inflammatory state. Endothelial cell dysfunction may be also triggered by inflammatory cytokines. Many factors involved in oxidative stress, inflammation, and thrombosis were proposed as cardiovascular risk markers showing the endothelial cell damage in PCOS. Those markers include asymmetric dimethylarginine (ADMA), C-reactive protein (CRP), homocysteine, plasminogen activator inhibitor-I (PAI-I), PAI-I activity, vascular endothelial growth factor (VEGF) etc. It was also proposed that the uterine hyperinflammatory state in polycystic ovary syndrome may be responsible for significant pregnancy complications ranging from miscarriage to placental insufficiency. In this review, we discuss the most importance evidence concerning the role of the process of chronic inflammation in pathogenesis of PCOS.
Excitatory Effects of Calcitonin Gene-Related Peptide (CGRP) on Superficial Sp5C Neurons in Mouse Medullary Slices
Authors: Zheng Fang , Nixdorf-Bergweiler Barbara E. , van Brederode Johannes , Alzheimer Christian , Messlinger Karl
Published: April 2021

The neuromodulator calcitonin gene-related peptide (CGRP) is known to facilitate nociceptive transmission in the superficial laminae of the spinal trigeminal nucleus caudalis (Sp5C). The central effects of CGRP in the Sp5C are very likely to contribute to the activation of central nociceptive pathways leading to attacks of severe headaches like migraine. To examine the potential impacts of CGRP on laminae I/II neurons at cellular and synaptic levels, we performed whole-cell patch-clamp recordings in juvenile mouse brainstem slices. First, we tested the effect of CGRP on cell excitability, focusing on neurons with tonically firing action potentials upon depolarizing current injection. CGRP (100 nM) enhanced tonic discharges together with membrane depolarization, an excitatory effect that was significantly reduced when the fast synaptic transmissions were pharmacologically blocked. However, CGRP at 500 nM was capable of exciting the functionally isolated cells, in a nifedipine-sensitive manner, indicating its direct effect on membrane intrinsic properties. In voltage-clamped cells, 100 nM CGRP effectively increased the frequency of excitatory synaptic inputs, suggesting its preferential presynaptic effect. Both CGRP-induced changes in cell excitability and synaptic drives were prevented by the CGRP receptor inhibitor BIBN 4096BS. Our data provide evidence that CGRP increases neuronal activity in Sp5C superficial laminae by dose-dependently promoting excitatory synaptic drive and directly enhancing cell intrinsic properties. We propose that the combination of such pre- and postsynaptic actions of CGRP might underlie its facilitation in nociceptive transmission in situations like migraine with elevated CGRP levels.
Analysis of the Temporal and Spatial Characteristics of Material Cultural Heritage Driven by Big Data—Take Museum Relics as an Example
Authors: Li Penglong , Shi Zuoqin , Ding Yi , Zhao Ling , Ma Zezhong , Xiao He , Li Haifeng
Published: April 2021

Museum cultural relics represent a special material cultural heritage, and modern interpretations of them are needed in current society. Based on the catalogue data of cultural relics published by the State Administration of Cultural Heritage, this paper analyzes the continuity and intermittentness of cultural relics in time series by using the method of continuity judgment of cultural relics, analyzes the aggregation and migration of cultural relics in space by using the method of spatial analysis, and then uses cosine similarity to explain the similarity distribution in space and time. The results show that the overall distribution of cultural relics exhibits the characteristics of class aggregation, dynasty aggregation and regional aggregation. From the perspective of a time scale, cultural relics have different “life cycles”, displaying continuity, intermittentness, and similarity. From the perspective of a spatial scale, the cultural relic distribution forms a small “cultural communication circle”, showing aggregation, migration, and similarity. The temporal and spatial distribution of cultural relics exhibited more similar characteristics among dynasties that were closer together than those that were far away.
Diagnostic Splenectomy: Characteristics, Pre-Operative Investigations, and Identified Pathologies for 20 Patients
Authors: Maillot Jean , Malfuson Jean-Valère , Lazure Thierry , Benoist Stéphane , Cremades Anne , Hornez Emmanuel , Besson Florent L. , Noël Nicolas , Lambotte Olivier
Published: April 2021

Splenectomy is indicated in cases of trauma to the spleen or hematological and immunological diseases (hereditary spherocytosis, autoimmune cytopenia). Less frequently, splenectomy is performed for diagnostic purposes to complement unsuccessful prior etiological investigations. The splenectomy remains a surgery at risk of complications and should be considered as a last-resort procedure to make the diagnosis and to be able to treat patients. We studied the medical files of 142 patients who underwent a splenectomy for any reason over a 10-year period and identified 20 diagnostic splenectomies. Diagnostic splenectomies were mainly performed to explore unexplained splenomegaly for 13 patients and fever of unknown origin for 10. The other patients had surgery for other causes (cytopenia, abdominal symptoms, suspicion of relapsing malignant hemopathies). Splenectomy contributed to the final diagnosis in 19 of 20 cases, corresponding mostly to lymphoid hemopathies (14/20). The most frequent disease was diffuse large B-cell lymphoma (8/20). Splenectomy did not reveal any infectious disease. The most relevant pre-operative procedures to aid the diagnosis were 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and immuno-hematological examinations. Diagnostic splenectomy is useful and necessary in certain difficult diagnostic situations. Highlights: Diagnostic splenectomy is still useful in 2020 to diagnose unexplained splenomegaly or fever of unknown origin. Lymphoma was the most common final diagnosis. FDG PET/CT was the most useful tool to aid in the diagnosis.
Exploring the Biopsychosocial Pathways Shared by Obstructive Sleep Apnea (OSA) and Central Serous Chorioretinopathy (CSC): A Literature Overview
Authors: Scarinci Fabio , Patacchioli Francesca Romana , Parravano Mariacristina
Published: April 2021

This study addressed the following question: “Is it possible to highlight the link between obstructive sleep apnea (OSA) and central serous chorioretinopathy (CSC) through common biopsychosocial pathogenetic pathways?”. The study was conducted through electronic searches of the PubMed, Web of Science, and Scopus databases. All relevant selected human research studies published from January 2003 to December 2020 were included. The scientific literature search was performed through repeated use of the words “OSA” and/or “acute/chronic CSC” paired with “biomedical/biopsychosocial illness model”, “psychopathology”, “stress”, “personality characteristics”, “functional diseases”, “comorbidity”, and “quality of life” in different combinations. Our literature search identified 213 reports, of which 54 articles were ultimately reviewed in this paper. Taken together, the results indicate that there is a cross-link between OSA and CSC that can be classified among biopsychological disorders in which various major biological variables integrate with psychological-functional and sociological variables; many of these variables appear in both diseases. This concept can have important implications for improving patients’ quality of life, thus providing the necessary strategies to cope with challenging life events even through nonpharmacological approaches.
Circulating HPV DNA in the Management of Oropharyngeal and Cervical Cancers: Current Knowledge and Future Perspectives
Authors: Krasniqi Eriseld , Barba Maddalena , Venuti Aldo , Pizzuti Laura , Cappuzzo Federico , Landi Lorenza , Carpano Silvia , Marchetti Paolo , Villa Alice , Vizza Enrico , Giuliano Greta , Mazzotta Marco , Marinelli Daniele , Gnignera Sandra , Vincenzoni Cristina , Stranges Vincenzo , Sergi Domenico , Giordano Antonio , Tomao Federica , Maugeri-Saccà Marcello , Sanguineti Giuseppe , Di Lisa Francesca Sofia , Tomao Silverio , Ciliberto Gennaro , Vici Patrizia
Published: April 2021

Human papillomaviruses (HPVs) are associated with invasive malignancies, including almost 100% of cervical cancers (CECs), and 35–70% of oropharyngeal cancers (OPCs). HPV infection leads to clinical implications in related tumors by determining better prognosis and predicting treatment response, especially in OPC. Currently, specific and minimally invasive tests allow for detecting HPV-related cancer at an early phase, informing more appropriately therapeutical decisions, and allowing for timely disease monitoring. A blood-based biomarker detectable in liquid biopsy represents an ideal candidate, and the use of circulating HPV DNA (ct-DNA) itself could offer the highest specificity for such a scope. Circulating HPV DNA is detectable in the greatest part of patients affected by HPV-related cancers, and studies have demonstrated its potential usefulness for CEC and OPC clinical management. Unfortunately, when using conventional polymerase chain reaction (PCR), the detection rate of serum HPV DNA is low. Innovative techniques such as droplet-based digital PCR and next generation sequencing are becoming increasingly available for the purpose of boosting HPV ct-DNA detection rate. We herein review and critically discuss the most recent and representative literature, concerning the role of HPV ctDNA in OPC and CEC in the light of new technologies that could improve the potential of this biomarker in fulfilling many of the unmet needs in the clinical management of OPC and CEC patients.
Extracorporeal Membrane Oxygenation for Fulminant Myocarditis: Increase of Cardiac Enzyme and SOFA Score Is Associated with High Mortality
Authors: Lee Yun Im , Chung Suryeun , Yang Ji-Hyuk , Sung Kiick , Kim Darae , Choi Jin-Oh , Jeon Eun-Seok , Yang Jeong Hoon , Cho Yang Hyun
Published: April 2021

We aimed to evaluate the outcomes of patients with fulminant myocarditis and investigate the factors associated with mortality. This is a retrospective single-center cohort study that included adult and pediatric patients with fulminant myocarditis treated at Samsung Medical Center between September 2004 and December 2019. The primary outcome was in-hospital mortality. Among 100 patients, 71 underwent veno-arterial extracorporeal membrane oxygenation (ECMO) (ECMO group). Comorbidities were not significantly different between the ECMO and non-ECMO groups. Cardiac enzymes, creatinine, and median sequential organ failure assessment (SOFA) score at intensive care unit admission were significantly different between the groups. Twenty patients (28.7%) in the ECMO group and two (6.9%) in the non-ECMO group died in-hospital (p = 0.02). The significant risk factors of in-hospital mortality were creatine kinase MB fraction (CK-MB) and SOFA score (p = 0.009 and p = 0.001, respectively) in the ECMO group. In the receiver-operating characteristic curve analysis, the cutoffs of SOFA score and CK-MB were 12 and 94.74 ng/mL, respectively. The patients with both variables above the cutoffs showed significantly worse outcomes (p < 0.001). ECMO can be an effective treatment option for fulminant myocarditis. SOFA score and CK-MB are significant risk factors for in-hospital mortality.
Thrombocytopenia and Hemostatic Changes in Acute and Chronic Liver Disease: Pathophysiology, Clinical and Laboratory Features, and Management
Authors: Scharf Rüdiger E.
Published: April 2021

Thrombocytopenia, defined as a platelet count <150,000/μL, is the most common complication of advanced liver disease or cirrhosis with an incidence of up to 75%. A decrease in platelet count can be the first presenting sign and tends to be proportionally related to the severity of hepatic failure. The pathophysiology of thrombocytopenia in liver disease is multifactorial, including (i) splenomegaly and subsequently increased splenic sequestration of circulating platelets, (ii) reduced hepatic synthesis of thrombopoietin with missing stimulation both of megakaryocytopoiesis and thrombocytopoiesis, resulting in diminished platelet production and release from the bone marrow, and (iii) increased platelet destruction or consumption. Among these pathologies, the decrease in thrombopoietin synthesis has been identified as a central mechanism. Two newly licensed oral thrombopoietin mimetics/receptor agonists, avatrombopag and lusutrombopag, are now available for targeted treatment of thrombocytopenia in patients with advanced liver disease, who are undergoing invasive procedures. This review summarizes recent advances in the understanding of defective but at low level rebalanced hemostasis in stable cirrhosis, discusses clinical consequences and persistent controversial issues related to the inherent bleeding risk, and is focused on a risk-adapted management of thrombocytopenia in patients with chronic liver disease, including a restrictive transfusion regimen.
Comparison of Prognostic Performance between Neuron-Specific Enolase and S100 Calcium-Binding Protein B Obtained from the Cerebrospinal Fluid of Out-of-Hospital Cardiac Arrest Survivors Who Underwent Targeted Temperature Management
Authors: Kang Changshin , Jeong Wonjoon , Park Jung Soo , You Yeonho , Min Jin Hong , Cho Yong Chul , Ahn Hong Joon
Published: April 2021

We compared the prognostic performances of serum neuron-specific enolase (sNSE), cerebrospinal fluid (CSF) NSE (cNSE), and CSF S100 calcium-binding protein B (cS100B) in out-of-hospital cardiac arrest (OHCA) survivors. This prospective observational study enrolled 45 patients. All samples were obtained immediately and at 24 h intervals until 72 h after the return of spontaneous circulation. The inter- and intragroup differences in biomarker levels, categorized by 3 month neurological outcome, were analyzed. The prognostic performances were evaluated with receiver operating characteristic curves. Twenty-two patients (48.9%) showed poor outcome. At all-time points, sNSE, cNSE, and cS100B were significantly higher in the poor outcome group than in the good outcome group. cNSE and cS100B significantly increased over time (baseline vs. 24, 48, and 72 h) in the poor outcome group than in the good outcome group. sNSE at 24, 48, and 72 h showed significantly lower sensitivity than cNSE or cS100B. The sensitivities associated with 0 false-positive rate (FPR) for cNSE and cS100B were 66.6% vs. 45.5% at baseline, 80.0% vs. 80.0% at 24 h, 84.2% vs. 94.7% at 48 h, and 88.2% (FPR, 5.0%) vs. 94.1% at 72 h. High cNSE and cS100B are strong predictors of poor neurological outcome in OHCA survivors. Multicenter prospective studies may determine the generalizability of these results.
Emerging Protein Biomarkers for the Diagnosis or Prediction of Gestational Diabetes—A Scoping Review
Authors: Bogdanet Delia , Reddin Catriona , Murphy Dearbhla , Doheny Helen C. , Halperin Jose A. , Dunne Fidelma , O’Shea Paula M.
Published: April 2021

Introduction: Gestational diabetes (GDM), defined as hyperglycemia with onset or initial recognition during pregnancy, has a rising prevalence paralleling the rise in type 2 diabetes (T2DM) and obesity. GDM is associated with short-term and long-term consequences for both mother and child. Therefore, it is crucial we efficiently identify all cases and initiate early treatment, reducing fetal exposure to hyperglycemia and reducing GDM-related adverse pregnancy outcomes. For this reason, GDM screening is recommended as part of routine pregnancy care. The current screening method, the oral glucose tolerance test (OGTT), is a lengthy, cumbersome and inconvenient test with poor reproducibility. Newer biomarkers that do not necessitate a fasting sample are needed for the prompt diagnosis of GDM. The aim of this scoping review is to highlight and describe emerging protein biomarkers that fulfill these requirements for the diagnosis of GDM. Materials and Methods: This scoping review was conducted according to preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines for scoping reviews using Cochrane Central Register of Controlled Trials (CENTRAL), the Cumulative Index to Nursing & Allied Health Literature (CINAHL), PubMed, Embase and Web of Science with a double screening and extraction process. The search included all articles published in the literature to July 2020. Results: Of the 3519 original database citations identified, 385 were eligible for full-text review. Of these, 332 (86.2%) were included in the scoping review providing a total of 589 biomarkers studied in relation to GDM diagnosis. Given the high number of biomarkers identified, three post hoc criteria were introduced to reduce the items set for discussion: we chose only protein biomarkers with at least five citations in the articles identified by our search and published in the years 2017–2020. When applied, these criteria identified a total of 15 biomarkers, which went forward for review and discussion. Conclusions: This review details protein biomarkers that have been studied to find a suitable test for GDM diagnosis with the potential to replace the OGTT used in current GDM screening protocols. Ongoing research efforts will continue to identify more accurate and practical biomarkers to take GDM screening and diagnosis into the 21st century.
Severe Tachycardia Associated with Psychotropic Medications in Psychiatric Inpatients: A Study of Hospital Medical Emergency Team Activation
Authors: Lim Andy K. H. , Azraai Meor , Pham Jeanette H. , Looi Wenye F. , Wirth Daniel , Ng Ashley S. L. , Babu Umesh , Saluja Bharat
Published: April 2021

The use of antipsychotic medications is associated with side effects, but the occurrence of severe tachycardia (heart rate ≥ 130 per minute) is not well described. The aim of this study was to determine the frequency and strength of the association between antipsychotic use and severe tachycardia in an inpatient population of patients with mental illness, while considering factors which may contribute to tachycardia. We retrospectively analyzed data from 636 Medical Emergency Team (MET) calls occurring in 449 psychiatry inpatients in three metropolitan hospitals co-located with acute medical services, and used mixed-effects logistic regression to model the association between severe tachycardia and antipsychotic use. The median age of patients was 42 years and 39% had a diagnosis of schizophrenia or psychotic disorder. Among patients who experienced MET calls, the use of second-generation (atypical) antipsychotics was commonly encountered (70%), but the use of first-generation (conventional) antipsychotics was less prevalent (10%). Severe tachycardia was noted in 22% of all MET calls, and sinus tachycardia was the commonest cardiac rhythm. After adjusting for age, anticholinergic medication use, temperature >38 °C and hypoglycemia, and excluding patients with infection and venous thromboembolism, the odds ratio for severe tachycardia with antipsychotic medication use was 4.09 (95% CI: 1.64 to 10.2).
Association of Olfactory and Pulmonary Function in Middle-Aged and Older Adults: The Korea National Health and Nutrition Examination Survey
Authors: Kim Ji-Sun , Park Jun-Ook , Lee Dong-Hyun , Chang Ki-Hong , Kim Byung Guk
Published: April 2021

Objectives: To identify the relationship between pulmonary function and subjective olfactory dysfunction in middle-aged and older adults. Materials and Methods: We used Korea National Health and Nutrition Examination Survey data from 2010 to 2012 to analyze 6191 participants in their 50s or older. Results: The frequency of olfactory dysfunction was 6.8% among the subjects with normal pulmonary function tests, but was significantly more frequent in those diagnosed with restrictive (9.6%) or obstructive (10.1%) pulmonary function. Forced volume vital capacity, forced expiratory volume (FEV)1, FEV6, and peak expiratory flow were significantly lower in the olfactory dysfunction group. The risk of olfactory dysfunction was significantly associated with obstructive pulmonary function (odds ratio (OR) [95% confidence interval (CI)]: 1.449 [1.010–2.081]) after adjusting for confounders (sex, rhinitis, chronic rhinosinusitis, hypertension, dyslipidemia, education level, stress, depressed mood, and suicidal ideation). Conclusion: Middle-aged and older adults with obstructive pulmonary function had a higher incidence of subjective olfactory dysfunction than the normal pulmonary function group. Early olfactory testing may improve the quality of life of patients with obstructive pulmonary function.
Effect of Growth Factor-Loaded Acellular Dermal Matrix/MSCs on Regeneration of Chronic Tympanic Membrane Perforations in Rats
Authors: Cho Gwang-Won , Moon Changjong , Song Anji , Vijayakumar Karthikeyan A. , Ang Mary Jasmin , Jang Chul Ho
Published: April 2021

The success rate of grafting using acellular dermal matrix (ADM) for chronic tympanic membrane was reported in previous studies to be lower than fascia or perichondrium. Combining mesenchymal stem cells (MSCs) and growth factor-loaded ADM for the regeneration of chronic TMP has not been reported so far. In this study, we hypothesized that combining growth factor-loaded ADM/MSCs could promote the recruitment of MSCs and assist in TMP regeneration. We evaluated the regeneration and compared the performance of four scaffolds in both in vitro and in vivo studies. MTT, qPCR, and immunoblotting were performed with MSCs. In vivo study was conducted in 4 groups (control; ADM only, ADM/MSC, ADM/MSC/bFGF, ADM/MSC/EGF) of rats and inferences were made by otoendoscopy and histological changes. Attachment of MSCs on ADM was observed by confocal microscopy. Proliferation rate increased with time in all treated cells. Regeneration-related gene expression in the treated groups was higher. Also, graft success rate was significantly higher in ADM/MSC/EGF group than other groups. Significant relationships were disclosed in neodrum thickness between each group. The results suggest, in future, combining EGF with ADM/MSCs could possibly be used as an outpatient treatment, without the need for surgery for eardrum regeneration.
Relationship between Cardiopulmonary, Mitochondrial and Autonomic Nervous System Function Improvement after an Individualised Activity Programme upon Chronic Fatigue Syndrome Patients
Authors: Kujawski Sławomir , Cossington Jo , Słomko Joanna , Zawadka-Kunikowska Monika , Tafil-Klawe Małgorzata , Klawe Jacek , Buszko Katarzyna , Jakovljevic Djordje , Kozakiewicz Mariusz , Morten Karl , Dawes Helen , Strong James , Murovska Modra , Van Oosterwijck Jessica , Estevez-Lopez Fernando , Newton Julia , Hodges Lynette , Zalewski Paweł ,   on behalf of the European Network on ME/CFS (EUROMENE)
Published: April 2021

Background: The therapeutic effects of exercise from structured activity programmes have recently been questioned; as a result, this study examines the impact of an Individualised Activity Program (IAP) on the relationship with cardiovascular, mitochondrial and fatigue parameters. Methods: Chronic fatigue syndrome (CFS) patients were assessed using Chalder Fatigue Questionnaire (CFQ), Fatigue Severity Score (FSS) and the Fatigue Impact Scale (FIS). VO2peak, VO2submax and heart rate (HR) were assessed using cardiopulmonary exercise testing. Mfn1 and Mfn2 levels in plasma were assessed. A Task Force Monitor was used to assess ANS functioning in supine rest and in response to the Head-Up Tilt Test (HUTT). Results: Thirty-four patients completed 16 weeks of the IAP. The CFQ, FSS and FIS scores decreased significantly along with a significant increase in Mfn1 and Mfn2 levels (p = 0.002 and p = 0.00005, respectively). The relationships between VO2 peak and Mfn1 increase in response to IAP (p = 0.03) and between VO2 at anaerobic threshold and ANS response to the HUTT (p = 0.03) were noted. Conclusions: It is concluded that IAP reduces fatigue and improves functional performance along with changes in autonomic and mitochondrial function. However, caution must be applied as exercise was not well tolerated by 51% of patients.
Current Status of Liquid Metal Printing
Authors: Ansell Troy Y.
Published: April 2021

This review focuses on the current state of the art in liquid metal additive manufacturing (AM), an emerging and growing family of related printing technologies used to fabricate near-net shape or fully free-standing metal objects. The various printing modes and droplet generation techniques as applied to liquid metals are discussed. Two different printing modes, continuous and drop-on-demand (DOD), exist for liquid metal printing and are based on commercial inkjet printing technology. Several techniques are in various stages of development from laboratory testing, prototyping, to full commercialization. Printing techniques include metal droplet generation by piezoelectric actuation or impact-driven, electrostatic, pneumatic, electrohydrodynamic (EHD), magnetohydrodynamic (MHD) ejection, or droplet generation by application of a high-power laser. The impetus for development of liquid metal printing was the precise, and often small scale, jetting of solder alloys for microelectronics applications. The fabrication of higher-melting-point metals and alloys and the printing of free-standing metal objects has provided further motivation for the research and development of liquid metal printing.
Representative Transmission Coefficient for Evaluating the Wave Attenuation Performance of 3D Floating Breakwaters in Regular and Irregular Waves
Authors: Nguyen Huu Phu , Park Jeong Cheol , Han Mengmeng , Wang Chien Ming , Abdussamie Nagi , Penesis Irene , Howe Damon
Published: April 2021

Wave attenuation performance is the prime consideration when designing any floating breakwater. For a 2D hydrodynamic analysis of a floating breakwater, the wave attenuation performance is evaluated by the transmission coefficient, which is defined as the ratio between the transmitted wave height and the incident wave height. For a 3D breakwater, some researchers still adopted this evaluation approach with the transmitted wave height taken at a surface point, while others used the mean transmission coefficient within a surface area. This paper aims to first examine the rationality of these two evaluation approaches via verified numerical simulations of 3D heave-only floating breakwaters in regular and irregular waves. A new index—a representative transmission coefficient—is then presented for one to easily compare the wave attenuation performances of different 3D floating breakwater designs.
Managers’ Investment Decisions: Incentives and Economic Consequences Arising from Leases
Authors: Eaton Tim V. , Nichols Craig , Wahlen James , Wieland Matthew
Published: April 2021

What incentives do managers face that might give rise to inefficient investments in leases? If managers make inefficient investments in leases, what economic consequences arise for those managers and their firms? We develop a model of expected investments in leased assets and use the residuals from the model as proxies for inefficient investments. We find that, in contrast to investments in capital expenditures, leasing appears to be a mechanism through which managers can seemingly over-invest, even among firms with high quality financial reporting and negative free cash flows. Examining economic consequences, we predict and find that unexpected investments in leased assets trigger increasing future sales growth but declining future earnings growth for as long as three years ahead. We also find a negative relation with contemporaneous stock returns, suggesting investors view unexpected investments in leases as value destructive. Finally, despite negative returns consequences, we find that unexpected investments in leases are associated with higher CEO compensation driven primarily by future sales growth. Our study suggests that compensation contracts that reward growth may give managers’ incentives to drive sales growth with larger-than-expected investments in leased assets, which lead to slower future earnings growth and negative share price consequences for investors. Our results should inform managers and board members, investors, and researchers interested in investment efficiency, corporate governance, and leases.
The Role of Institutional Investors in Improving Board of Director Attributes around the World
Authors: Alshabibi Badar
Published: April 2021

This paper investigates the role of institutional investors in the improvement of corporate governance for the companies in which they invest (investee companies) using evidence about the attributes of boards of directors across 15 countries. Furthermore, this paper examines the extent to which the activism of institutional investors is determined by the institutional environment, to include various economic conditions (pre-crisis, crisis and post-crisis), legal systems and ownership structures. Drawing from the agency theory and institutional theory, the results show that foreign institutional investors are the main promoters of board governance structures across the globe. This study also provides evidence that institutional investors promote the independence of a board and its audit and compensation sub-committees (but excluding its nomination committee). The study also demonstrates that institutional investors reduce board entrenchment, though it presents no evidence that institutional investors reduce board busyness. The results also suggest that institutional investors behave differently when operating within different economic conditions (pre-crisis, crisis and post-crisis), legal systems and ownership structures. This paper contributes to the growing literature on shareholder activism and comparative corporate governance mechanisms. The findings suggest that the activism of institutional investors is contingent on the institutional settings, to include economic conditions, legal systems and ownership structures.
Construction and Optimization of Ecological Security Pattern Based on Spatial Syntax Classification—Taking Ningbo, China, as an Example
Authors: Han Yu , Yu Chaoyue , Feng Zhe , Du Hanchu , Huang Caisi , Wu Kening
Published: April 2021

Urbanization is the development trend of all countries in the world, but it has caused considerable ecological problems that need to be alleviated by building ecological security patterns. This study took Ningbo as an example to construct and optimize an ecological security pattern. We analyzed land use types, normalized difference vegetation index, and landscape connectivity for ecological sources selection. In constructing the resistance surface, we considered natural and socio-economic factors. On this basis, we identified ecological corridors based on a minimum cumulative resistance model. Finally, the ecological security pattern was optimized through space syntax. Results showed that Ningbo has 18 ecological sources, with an area of 3051.27 km2 and 29 ecological corridors, with a length of 1172.18 km. Among them, 11 are first-level, 10 are second-level, and 8 are third-level corridors. After optimization, the area and protection cost of the ecological security pattern were significantly reduced, which can effectively alleviate the trade-off between ecological protection and economic development. This research can provide a reference for the construction and optimization of ecological security patterns and has reference significance for ecological protection in rapidly urbanized areas.
Communities of Practice in the Warlpiri Triangle: Four Decades of Crafting Ideological and Implementational Spaces for Teaching in and of Warlpiri Language
Authors: Browne Emma , Napaljarri Fiona Gibson
Published: April 2021

Warlpiri communities in Australia’s Northern Territory (NT) have long advocated for the inclusion of Warlpiri language, values and knowledge in their government-run schools. After the first bilingual programs were established in the NT in the 1970s, educators and community members from four Warlpiri communities formed a professional network known as the Warlpiri Triangle, a platform for meetings and professional development focusing on teaching and learning in and of Warlpiri language in schools. On these platforms, educators have consistently articulated the goal of the Warlpiri programs as maintenance of Warlpiri pirrjirdi, ‘strong Warlpiri language’. In this paper we seek to explore the development, refinement and consolidation of a consensual ideology around teaching and learning of and in Warlpiri pirrjirdi, ‘strong Warlpiri language’ that has informed Warlpiri language-in-education management. We analyse interviews with five Warlpiri educators at Yuendumu school in 2018/9 and a body of grey literature from four decades of Warlpiri educator professional development activities that has been less widely acknowledged and visible in local education policy discourse. We draw on the theoretical concept of communities of practice to understand the ways in which Warlpiri educators negotiate ideological and implementational spaces for inclusion of Warlpiri language teaching in the context of an ambivalent language-in-education policy environment. The results of this study exemplify the reiteration and reproduction of language-in-education goals through a community of practice in a sustained arena of action, the Warlpiri Triangle. The findings render more visible the vital efforts of Warlpiri educators and their professional networks in shaping language-in-education policy and practice to realise community aspirations of Warlpiri language maintenance in the school context.
Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective
Authors: Chakraborty Arka , Mitra Saikat , Tallei Trina , Tareq Abu , Nainu Firzan , Cicia Donatella , Dhama Kuldeep , Emran Talha , Simal-Gandara Jesus , Capasso Raffaele
Published: April 2021

Bromelain is an effective chemoresponsive proteolytic enzyme derived from pineapple stems. It contains several thiol endopeptidases and is extracted and purified via several methods. It is most commonly used as an anti-inflammatory agent, though scientists have also discovered its potential as an anticancer and antimicrobial agent. It has been reported as having positive effects on the respiratory, digestive, and circulatory systems, and potentially on the immune system. It is a natural remedy for easing arthritis symptoms, including joint pain and stiffness. This review details bromelain’s varied uses in healthcare, its low toxicity, and its relationship to nanoparticles. The door of infinite possibilities will be opened up if further extensive research is carried out on this pineapple-derived enzyme.