bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimising Citizen-Driven Air Quality Monitoring Networks for Cities
Authors: Gupta Shivam , Pebesma Edzer , Degbelo Auriol , Costa Ana Cristina
Published: November 2018

Air quality has had a significant impact on public health, the environment and eventually on the economy of countries for decades. Effectively mitigating air pollution in urban areas necessitates accurate air quality exposure information. Recent advancements in sensor technology and the increasing popularity of volunteered geographic information (VGI) open up new possibilities for air quality exposure assessment in cities. However, citizens and their sensors are put in areas deemed to be subjectively of interest (e.g., where citizens live, school of their kids or working spaces), and this leads to missed opportunities when it comes to optimal air quality exposure assessment. In addition, while the current literature on VGI has extensively discussed data quality and citizen engagement issues, few works, if any, offer techniques to fine-tune VGI contributions for an optimal air quality exposure assessment. This article presents and tests an approach to minimise land use regression prediction errors on citizen-contributed data. The approach was evaluated using a dataset (N = 116 sensors) from the city of Stuttgart, Germany. The comparison between the existing network design and the combination of locations selected by the optimisation method has shown a drop in spatial mean prediction error by 52%. The ideas presented in this article are useful for the systematic deployment of VGI air quality sensors, and can aid in the creation of higher resolution, more realistic maps for air quality monitoring in cities.
Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage
Authors: Azevedo Raimunda , Araujo Marialva , Oliveira Consuelo , Martins Filho Arnaldo , Nunes Bruno , Henriques Daniele , Silva Eliana , Carvalho Valéria , Chiang Jannifer , Martins Lívia , Vasconcelos Barbara , Sousa Jorge , Araujo Fernanda , Ribeiro Erlane , Castro Andrezza , De Queiroz Maria , Verotti Mariana , Nunes Márcio , Cruz Ana , Rodrigues Sueli , Shi Pei-Yong , Quaresma Juarez , Tesh Robert , Vasconcelos Pedro
Published: November 2018

Introduction: The recent Zika virus(ZIKV) epidemic in Brazil was characterized by a range of different clinical presentations, particularly microcephaly, Guillain-Barré syndrome, and death. In this context, we determined the causal relationship between fatal microcephaly cases and ZIKV infection. Methods: Twelve fatal cases of neonates, whose mothers were infected with ZIKV during pregnancy, were examined; cases included nine neonatal deaths due to microcephaly, one miscarriage, and two stillbirths. Tissue samples were obtained from all cases at necropsy and were submitted for virological investigation (RT-qPCR and virus isolation) and/or histopathology (hematoxylin and eosin staining) and immunohistochemical assay for the detection of ZIKV antigens. Results: ZIKV antigens and/or ZIKV RNA were detected in tissue samples of all 12 cases examined. ZIKV was recovered in one case. Results of the virological and immunohistochemical analyses, as well as the anatomic abnormalities and histopathologic changes observed at necropsy on the 12 fatal cases, are presented. Conclusions: Data from these 12 cases provide strong evidence of the causal relationship between ZIKV and congenital disease in fetuses of women who were infected with the virus during pregnancy.
Prenatal Neuropathologies in Autism Spectrum Disorder and Intellectual Disability: The Gestation of a Comprehensive Zebrafish Model
Authors: Kozol Robert A.
Published: November 2018

Autism spectrum disorder (ASD) and intellectual disability (ID) are neurodevelopmental disorders with overlapping diagnostic behaviors and risk factors. These include embryonic exposure to teratogens and mutations in genes that have important functions prenatally. Animal models, including rodents and zebrafish, have been essential in delineating mechanisms of neuropathology and identifying developmental critical periods, when those mechanisms are most sensitive to disruption. This review focuses on how the developmentally accessible zebrafish is contributing to our understanding of prenatal pathologies that set the stage for later ASD-ID behavioral deficits. We discuss the known factors that contribute prenatally to ASD-ID and the recent use of zebrafish to model deficits in brain morphogenesis and circuit development. We conclude by suggesting that a future challenge in zebrafish ASD-ID modeling will be to bridge prenatal anatomical and physiological pathologies to behavioral deficits later in life.
Enhancing Reliability of Tactical MANETs by Improving Routing Decisions
Authors: Al-Shehri Salman M. , Loskot Pavel
Published: November 2018

Mobile ad-hoc networks (MANETs) have been primarily designed to enhance tactical communications in a battlefield. They provide dynamic connectivity without requiring any pre-existing infrastructure. Their multi-hop capabilities can improve radio coverage significantly. The nature of tactical MANET operations requires more specialized routing protocols compared to the ones which are used in commercial MANET. Routing decisions in MANETs are usually conditioned on signal-to-interference-plus-noise ratio (SINR) measurements. In order to improve routing decisions for use in highly dynamic tactical MANETs, this paper proposes to combine two different metrics to achieve reliable multicast in multi-hop ad hoc networks. The resulting protocol combining received signal strength (RSS) with SINR to make routing decisions is referred to as Link Quality Aware Ad-hoc On-Demand Distance Vector (LQA-AODV) routing. The proposed routing protocol can quickly adapt to dynamic changes in network topology and link quality variations often encountered in tactical field operations. Using computer simulations, the performance of proposed protocol is shown to outperform other widely used reactive routing protocols assuming several performance metrics.
Agricultural Land Conversion, Land Economic Value, and Sustainable Agriculture: A Case Study in East Java, Indonesia
Authors: Rondhi Mohammad , Pratiwi Pravitasari Anjar , Handini Vivi Trisna , Sunartomo Aryo Fajar , Budiman Subhan Arif
Published: November 2018

Agricultural land conversion (ALC) is an incentive-driven process. In this paper, we further investigate the inter-relationship between land economic value (LEV) and ALC. To achieve this goal, we calculated the LEV for agricultural and non-agricultural (housing) uses in two areas of East Java, Indonesia. The first area represents peri-urban agriculture, which is facing rapid urbanization and experiencing a high rate of ALC. The second area represents rural agriculture, with zero ALC. Furthermore, we identified factors affecting LEV in both areas for both uses. The results of this study show that agricultural land yielded a higher economic benefit in rural areas. Conversely, compared to agricultural land, housing in urban areas yields a value that is seven times higher. Moreover, agricultural land was shown to yield a higher profit after conversion. Ironically, a similar comparison does not exist in rural areas. Agricultural land yielded a value that was only 19% higher, indicating that agricultural land can easily be converted. This is also proven by the growing number of new urban cores in the periphery area. There are several factors affecting land economic value, such as agricultural use, soil fertility, accessibility, and cropping pattern, which are important variables. Meanwhile, the accessibility and location of peri-urban areas increase the land value for housing.
Manipulation of Pattern of Cell Differentiation in a hetR Mutant of Anabaena sp. PCC 7120 by Overexpressing hetZ Alone or with hetP
Authors: Zhang He , Xu Xudong
Published: November 2018

In the filamentous cyanobacterium, Anabaena sp. PCC 7120, single heterocysts differentiate at semi-regular intervals in response to nitrogen stepdown. HetR is a principal regulator of heterocyst differentiation, and hetP and hetZ are two genes that are regulated directly by HetR. In a hetR mutant generated from the IHB (Institute of Hydrobiology) substrain of PCC 7120, heterocyst formation can be restored by moderate expression of hetZ and hetP. The resulting heterocysts are located at terminal positions. We used a tandem promoter, PrbcLPpetE, to express hetZ and hetP strongly in the hetR mutant. Co-expression of hetZ and hetP enabled the hetR mutant to form multiple contiguous heterocysts at both terminal and intercalary positions. Expression of hetZ, alone resulted in terminally located heterocysts, whereas expression of hetP, alone produced enlarged cells in strings. In the absence of HetR, formation of heterocysts was insensitive to the peptide inhibitor, RGSGR.
Morphology, Thermal, Mechanical Properties and Rheological Behavior of Biodegradable Poly(butylene succinate)/poly(lactic acid) In-Situ Submicrofibrillar Composites
Authors: Zhu Zhiwen , He Hezhi , Xue Bin , Zhan Zhiming , Wang Guozhen , Chen Ming
Published: November 2018

In this study, biodegradable poly(butylene succinate)/poly(lactic acid) (PBS/PLA) in-situ submicrofibrillar composites with various PLA content were successfully produced by a triple-screw extruder followed by a hot stretching−cold drawing−compression molding process. This study aimed to investigate the effects of dispersed PLA submicro-fibrils on the thermal, mechanical and rheological properties of PBS/PLA composites. Morphological observations demonstrated that the PLA phases are fibrillated to submicro-fibrils in the PBS/PLA composites, and all the PLA submicro-fibrils produced seem to have a uniform diameter of about 200nm. As rheological measurements revealed, at low frequencies, the storage modulus (G’) of PBS/PLA composites has been increased by more than four orders of magnitude with the inclusion of high concentrations (15 wt % and 20 wt %) of PLA submicro-fibrils, which indicates a significant improvement in the elastic responses of PBS melt. Dynamic Mechanical Analysis (DMA) results showed that the glass transition temperature (Tg) of PBS phase slightly shifted to the higher temperature after the inclusion of PLA. DSC experiments proved that fiber morphology of PLA has obvious heterogeneous nucleation effect on the crystallization of PBS. The tensile properties of the PBS/PLA in-situ submicrofibrillar composites are also improved compared to neat PBS.
Compressive Strength and Durability Properties of Structural Lightweight Concrete with Fine Expanded Glass and/or Clay Aggregates
Authors: Rumsys Deividas , Spudulis Edmundas , Bacinskas Darius , Kaklauskas Gintaris
Published: November 2018

This study is focused on the experimental investigation of compressive strength and durability properties of lightweight concrete mixtures with fine expanded glass and expanded clay aggregates using different microfillers. The paper proposes the relationships between the compressive strength and density of concrete mixtures with different proportions of the lightweight aggregates mentioned above. The performed experimental studies have revealed the tendencies of possible usage of different amounts of fine lightweight aggregates and their combinations in the production of concrete mixtures depending on the demands of practical application. Following the requirements for structural concrete subjected to environmental effects, durability properties (alkaline corrosion and freeze–thaw resistance) of the selected concrete mixtures with expanded glass aggregate were studied. The results of the experimental investigations have shown that durability of tested concrete specimens was sufficient. The study has concluded that the mixtures under consideration can be applied for the production of structural elements to which durability requirements are significant.
Detection of Friction Stir Welding Defects of AA1060 Aluminum Alloy Using Specific Damping Capacity
Authors: AbuShanab Waheed Sami , Moustafa Essam B.
Published: November 2018

The demand for nondestructive testing has increased, especially in welding testing. In the current study, AA1060 aluminum plates were jointed using the friction stir welding (FSW) process. The fabricated joints were subjected to free vibration impact testing in order to investigate the dynamic properties of the welded joint. Damping capacity and dynamic modulus were used in the new prediction method to detect FSW defects. The data acquired were processed and analyzed using a dynamic pulse analyzer lab shop and ME’Scope’s post-processing software, respectively. A finite element analysis using ANSYS software was conducted on different types of designed defects to predict the natural frequency. The results revealed that defective welded joints significantly affect the specific damping capacity. As the damping ratio increased, so did the indication of opportunities to increase the presence of defects. The finite element simulation model was consistent with experimental work. It was therefore revealed that natural frequency was insufficient to predict smaller defects.
Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers
Authors: Wang Dan , Neupane Pratik , Ragnarsson Lotten , Capon Robert J. , Lewis Richard J.
Published: November 2018

T-type calcium channel (CaV3.x) blockers are receiving increasing attention as potential therapeutics for the treatment of pathophysiological disorders and diseases, including absence epilepsy, Parkinson’s disease (PD), hypertension, cardiovascular diseases, cancers, and pain. However, few clinically approved CaV3.x blockers are available, and selective pharmacological tools are needed to further unravel the roles of individual CaV3.x subtypes. In this work, through an efficient synthetic route to the marine fungal product pseudellone C, we obtained bisindole alkaloid analogs of pseudellone C with a modified tryptophan moiety and identified two CaV3.2 (2, IC50 = 18.24 µM; 3, IC50 = 6.59 µM) and CaV3.3 (2, IC50 = 7.71 µM; 3, IC50 = 3.81 µM) selective blockers using a FLIPR cell-based assay measuring CaV3.x window currents. Further characterization by whole-cell patch-clamp revealed a preferential block of CaV3.1 activated current (2, IC50 = 5.60 µM; 3, IC50 = 9.91 µM), suggesting their state-dependent block is subtype specific.
A Soft Coral-Derived Compound, 11-Dehydrosinulariolide, Induces G2/M Cell Cycle Arrest and Apoptosis in Small Cell Lung Cancer
Authors: Lin Yu-Chao , Su Jui-Hsin , Lin Shih-Chao , Chang Chia-Che , Hsia Te-Chun , Tung Yu-Tang , Lin Chi-Chien
Published: November 2018

11-Dehydrosinulariolide, an active compound that is isolated from the cultured soft coral Sinularia flexibilis, has been suggested to show anti-tumor biological characteristics according to previous studies. However, its potential effect on small cell lung cancer (SCLC) remains unknown. The present study investigates the underlying mechanism for the treatment of SCLC in vitro and in vivo. Cell viability was examined using the methyl-thiazol-diphenyl-tetrazolium (MTT) assay. Flow cytometry was applied to evaluate cell cycle distribution and apoptosis. The expression of proteins related to the cell cycle and apoptosis was analyzed by Western blot analysis. Additionally, an in vivo study was performed to determine the anti-SCLC effect on an H1688 subcutaneous tumor in a BALB/c nude mouse model. 11-Dehydrosinulariolide inhibited cell growth, triggered G2/M arrest and induced H1688 cell apoptosis in a dose- and time-dependent manner. Additionally, 11-dehydrosinulariolide caused the accumulation of p53 and Bax, accompanied by the activation of DNA damage-inducing kinases, including ataxia-telangiectasia mutated (ATM) and checkpoint kinase 2 (CHK2). Moreover, 11-dehydrosinulariolide increased the activity of caspase-3 and -7, suggesting that caspases are involved in 11-dehydrosinulariolide-induced apoptosis. 11-Dehydrosinulariolide also increased the level of tumor suppressor phosphatase and tensin homolog (PTEN) and inhibited the expression of phosphorylated Akt. In the in vivo study, the intraperitoneal injection of 11-dehydrosinulariolide at a dosage of 10 mg/kg significantly inhibited tumor growth compared with the control treatment. Together, the data indicate that 11-dehydrosinulariolide induces G (2)/M cell cycle arrest and apoptosis through various cellular processes, including the upregulation of p53 and Bax, activation of ATM and Chk2, activation of caspase-3 and -7, and accumulation of PTEN, leading to inhibition of the Akt pathway. These findings suggest that 11-dehydrosinulariolide might serve as a promising chemotherapy drug in the treatment of SCLC.
Process Simulation and Cost Evaluation of Carbon Membranes for CO2 Removal from High-Pressure Natural Gas
Authors: Chu Yunhan , He Xuezhong
Published: November 2018

Natural gas sweetening is required to remove the acid gas CO2 to meet gas grid specifications. Membrane technology has a great potential in this application compared to the state-of-the-art amine absorption technology. Carbon membranes are of particular interest due to their high CO2/CH4 selectivity of over 100. In order to document the advantages of carbon membranes for natural gas (NG) sweetening, HYSYS simulation and cost evaluation were conducted in this work. A two-stage carbon membrane process with recycling in the second stage was found to be technically feasible to achieve >98% CH4 with <2% CH4 loss. The specific natural gas processing cost of 1.122 × 10−2 $/m3 sweet NG was estimated at a feed pressure of 90 bar, which was significantly dependent on the capital-related cost. Future work on improving carbon membrane performance is required to increase the competitiveness of carbon membranes for natural gas sweetening.
Influence of Lateral Loading on Compaction Characteristics of Crushed Waste Rock Used for Backfilling
Authors: Li Meng , Zhang Jixiong , Sun Kai , Zhang Sheng
Published: November 2018

Crushed waste rock can be used as backfill in goafs to allow re-use of otherwise solid waste and to control surface subsidence. If a certain lateral stress is applied to crushed waste rocks beforehand, they are densified. Therefore, this research investigated the effects of lateral stress on compaction characteristics of waste rocks for backfilling by utilising a self-designed bidirectional loading test system for granular materials. Furthermore, this study tested the changes in the mechanical parameters on lateral and axial loading of waste rocks for backfilling and measured the influence of lateral stress on lateral strain, axial strain, porosity, and lateral pressure coefficient during compaction. The test results demonstrate that (1) lateral stress affects porosity, strain, and the lateral pressure coefficient of crushed waste rocks for backfilling in lateral and axial loading. (2) In lateral loading, the greater the lateral stress, the larger the lateral strain and the reduction in lateral porosity. (3) Under axial loading, for the samples on which a high lateral stress is applied, because the porosity of waste rocks is decreased in advance, the density increases, thus finally resulting in a lower axial strain. (4) After compaction, the particle size distributions of the samples of the crushed waste rocks under four lateral stresses all shift upwards compared with those before compaction, implying that particles are crushed. However, lateral stress does not reach the crushing strength of waste rock particles, which exerts only a small influence on the crushing of particles before and after compaction.
Chromosome Doubling-Enhanced Biomass and Dihydrotanshinone I Production in Salvia miltiorrhiza, A Traditional Chinese Medicinal Plant
Authors: Chen Elena Gamboa , Tsai Kang-Lun , Chung Hsiao-Hang , Chen Jen-Tsung
Published: November 2018

The root of Chinese sage (Salvia miltiorrhiza Bunge) was regarded as top-grade Chinese medicine two thousand years ago, according to Shen Nong Materia Medica. The aim of this study is to develop an easy and reliable means for obtaining tetraploids (4x plants) via thidiazuron-induced direct organogenesis in the presence of colchicine. The resulting 4x plants showed significantly enhanced agronomic traits, including the size of stomata, leaflet, pollen, and seed as well as shoot length, root diameter, number of leaves, and fresh weight of plant. In addition, an obvious reduction of length to width ratio was found in the 4x plants, including stomata, leaflets, pollens, seeds, and roots. The 4x ploidy state of the plants was stable as was proved by evaluation of selection indicators as well as consistent ploidy level at 10th generation plantlets and also on 4x seedlings obtained via self-pollination. The major bioactive compounds, salvianolic acid B, tanshinone I, tanshinone IIA, dihydrotanshinone I and cryptotanshinone, as well as total tanshinones were determined by high performance liquid chromatography (HPLC). The concentrations of dihydrotanshinone I and total tanshinones in the root extract of the 4x plants were significantly higher when compared with the 2x plants. This present study developed a simple and efficient system for inducing and subculture of tetrapolids which have stable ploidy level, enhanced growth characteristics as well as the content of dihydrotanshinone I in the root of S. miltiorrhiza.
Recent Studies on Cyclic 1,7-Diarylheptanoids: Their Isolation, Structures, Biological Activities, and Chemical Synthesis
Authors: Jahng Yurngdong , Park Jae Gyu
Published: November 2018

Diarylheptanoids are a family of plant secondary metabolites with a 7 carbon skeleton possessing two phenyl rings at the 1- and 7-positions. They can be subdivided into acyclic and cyclic diarylheptanoids where the latter are further divided into meta,meta-bridged biphenyls ([7.0]metacyclophanes) and meta,para-bridged diphenyl ether heptanoids (oxa[7.1]metapara-cyclophanes). Since the isolation of curcumin from the rhizomes of turmeric (Curcuma longa) in 1815 which was named curcumin, a variety of diarylheptanoids have been isolated from a number of plant families such as Aceraceae, Actinidiaceae, Betulaceae, Burseraceae, Casuarinaceae, Juglandaceae, Leguminosae, Myricaceae, and Zingiberaceae. Earlier studies on these diarylheptanoids have been summarized on several occasions, of which the main themes only focus on isolation, structure elucidation, and the biological properties of linear types. Only a few have covered cyclic diarylheptanoids and their chemical synthesis has been covered lastly by Zhu et al. in 2000. The present paper has, therefore, covered recent progress in cyclic diarylheptanoids focusing on the isolation, structural and biological features, and chemical synthesis.
Cloning, Characterization and Anion Inhibition Studies of a β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica
Authors: Haapanen Susanna , Bua Silvia , Kuuslahti Marianne , Parkkila Seppo , Supuran Claudiu
Published: November 2018

We report the cloning and catalytic activity of a β-carbonic anhydrase (CA, EC 4.2.1.1), isolated from the pathogenic protozoan Entamoeba histolytica, EhiCA. This enzyme has a high catalytic activity for the physiologic CO2 hydration reaction, with a kcat of 6.7 × 105 s−1 and a kcat/Km of 8.9 × 107 M−1 × s−1. An anion inhibition study of EhiCA with inorganic/organic anions and small molecules revealed that fluoride, chloride, cyanide, azide, pyrodiphosphate, perchlorate, tetrafluoroborate and sulfamic acid did not inhibit the enzyme activity, whereas pseudohalides (cyanate and thiocyanate), bicarbonate, nitrate, nitrite, diethyldithiocarbamate, and many complex inorganic anions showed inhibition in the millimolar range (KIs of 0.51–8.4 mM). The best EhiCA inhibitors were fluorosulfonate, sulfamide, phenylboronic acid and phenylarsonic acid (KIs in the range of 28–86 μM). Since β-CAs are not present in vertebrates, the present study may be useful for detecting lead compounds for the design of effective enzyme inhibitors, with potential to develop anti-infectives with alternative mechanisms of action.
Development and In Vitro Evaluation of Linear PEI-Shelled Heparin/Berberine Nanoparticles in Human Osteosarcoma U-2 OS Cells
Authors: Hsu Hung-Kun , Hsu Kuang-Hsing , Cheng Ya-Ming , Suen Hao-Yi , Peng Shu-Fen
Published: November 2018

Berberine (BBR), a natural isoquinoline alkaloid derived from Chinese herbs, exerts many biological effects, including antiviral, antimicrobial, antidiarrhea, anti-inflammatory, and antitumor effects. In this study, a novel berberine nanoparticle (NP) consisting of heparin (HP) and BBR with or without being shelled with linear polyethyleneimine (LPEI) was developed to enhance its antitumor activity on osteosarcoma U-2 OS cells. With varying ratios of HP to BBR, HP/BBR NPs had a size ranging from 218.4 ± 3.9 to 282.0 ± 5.1 nm and zeta potential from −35.7 ± 0.4 to −51.9 ± 1.8 mV. After shelling with LPEI, the resultant NPs (HP/BBR/LPEI) possessed a size ranging from 226.3 ± 3.0 to 405.7 ± 85.2 nm and zeta potential from −46.5 ± 0.3 to −35.6 ± 0.5 mV; the encapsulation rate of BBR was close to 80%. The release profiles of both NPs were revealed to be slower than that of BBR solution. Results also showed that BBR and its two derived NPs reduced the viability of U-2 OS cells, and BBR NPs increased the cellular uptake of BBR. Cells were arrested at the G1 phase when treated individually with BBR and the two NPs (HP/BBR and HP/BBR/LPEI) and DNA condensation was induced. In addition, BBR and BBR NPs reduced the expression of mouse double minute 2 homolog (MDM2) but increased that of p53, and BBR NPs enhanced apoptotic effects. In short, heparin-based nanoparticles could be potential carriers for osteosarcoma treatment.
The Degradation Products of Ascorbic Acid Inhibit Amyloid Fibrillation of Insulin and Destabilize Preformed Fibrils
Authors: Yang Lu-Fei , Zeng Cheng-Ming
Published: November 2018

Ascorbic acid (AsA) is an important antioxidant and enzyme cofactor in many biochemical processes. Most biological activities of AsA are closely related to its redox properties. Recent investigations have demonstrated that AsA is associated with amyloid-related diseases and can inhibit amyloid aggregation of polypeptides. In the present study, we determined the kinetics of AsA degradation and investigated the anti-amyloidogenic activities of AsA and its degradation products by utilizing insulin as a model polypeptide. The results showed that the half-life of AsA varied with the pH of the medium and the incubation temperature. The degradation products of AsA inhibited insulin fibrillation, with an activity positively correlated to the degree of AsA degradation. The degradation species, compared with intact AsA, also showed a stronger disruptive effect on mature amyloid fibrils and significantly decreased fibrillar cytotoxicity. Dehydroascorbic acid and diketogulonic acid, two key intermediates in AsA degradation, had similar anti-amyloidogenic activity toward the degradation species of AsA. The results of this work indicate that degradation of natural antioxidants must be considered when evaluating their anti-amyloidogenic effects. These insights into the action of AsA may also provide a novel route to understand its physiological/pharmacological roles in amyloid-related diseases.
Comparison of Phenols Content and Antioxidant Activity of Fruits from Different Maturity Stages of Ribes stenocarpum Maxim
Authors: Wang Yuwei , Qi Delin , Wang Shulin , Cao Xiaohai , Ye Ying , Suo Yourui
Published: November 2018

Differences in the content of nine phenols and the antioxidant capacity of Ribes stenocarpum Maxim (RSM) fruits at different stages of maturity were investigated, and the extraction process of polyphenols from RSM was also optimized using Box-Behnken design method. Results showed that the content of the nine phenols varied considerably at different ripening stages; catechin, chlorogenic acid, coumaric acid, and ferulic acid were abundant in immature fruits but decreased with fruit ripening, whereas the levels of rosemary acid and querctin acid were low in immature fruits and increased with time, reaching the highest value after the fruit was completely mature. The phenols extracted from RSM fruits possessed good antioxidant activities for effective and rapid scavenging of DPPH and ABTS free radicals, as well as intracellular ROS. Analysis of the phenols content at different maturity stages indicated that the unripe fruits had significantly higher polyphenols content than mature fruits. Consequently, unripe fruits possessed higher antioxidant activities. According to the overall results of the extraction process optimization, the selected optimal conditions for extracting polyphenols from RSM were as follows: extraction time, 95 min; solvent concentration, 60%; ratio of sample to solvent, 1:25.
Mechanochemical Catalytic Transfer Hydrogenation of Aromatic Nitro Derivatives
Authors: Portada Tomislav , Margetić Davor , Štrukil Vjekoslav
Published: November 2018

Mechanochemical ball milling catalytic transfer hydrogenation (CTH) of aromatic nitro compounds using readily available and cheap ammonium formate as the hydrogen source is demonstrated as a simple, facile and clean approach for the synthesis of substituted anilines and selected pharmaceutically relevant compounds. The scope of mechanochemical CTH is broad, as the reduction conditions tolerate various functionalities, for example nitro, amino, hydroxy, carbonyl, amide, urea, amino acid and heterocyclic. The presented methodology was also successfully integrated with other types of chemical reactions previously carried out mechanochemically, such as amide bond formation by coupling amines with acyl chlorides or anhydrides and click-type coupling reactions between amines and iso(thio)cyanates. In this way, we showed that active pharmaceutical ingredients Procainamide and Paracetamol could be synthesized from the respective nitro-precursors on milligram and gram scale in excellent isolated yields.
Full Tetragonal Phase Stabilization in ZrO2 Nanoparticles Using Wet Impregnation: Interplay of Host Structure, Dopant Concentration and Sensitivity of Characterization Technique
Authors: Colbea Claudiu , Avram Daniel , Cojocaru Bogdan , Negrea Raluca , Ghica Corneliu , Kessler Vadim G. , Seisenbaeva Gulaim A. , Parvulescu Vasile , Tiseanu Carmen
Published: November 2018

Here, we show that wet impregnation of ZrO2 nanoparticles with 10% and 20% Eu oxide followed by thermal anneal in air above 500 °C produces full stabilization of the tetragonal phase of ZrO2 without evidencing any phase separation. The bare ZrO2 nanoparticles were obtained using three synthetic methods: oil in water microemulsion, rapid hydrothermal, and citrate complexation methods. The homogeneity of the solid solutions was assessed using X-ray diffraction, Raman spectroscopy, high resolution transmission electron microscopy, and advanced luminescence spectroscopy. Our findings show that wet impregnation, which is a recognized method for obtaining surface doped oxides, can be successfully used for obtaining doped oxides in the bulk with good homogeneity at the atomic scale. The limits of characterization technique in detecting minor phases and the roles of dopant concentration and host structure in formation of phase stabilized solid solutions are also analyzed and discussed.
Energy Conservation and the Correlation Quasi-Temperature in Open Quantum Dynamics
Authors: Morozov Vladimir , Ignatyuk Vasyl’
Published: November 2018

The master equation for an open quantum system is derived in the weak-coupling approximation when the additional dynamical variable—the mean interaction energy—is included into the generic relevant statistical operator. This master equation is nonlocal in time and involves the “quasi-temperature”, which is a non- equilibrium state parameter conjugated thermodynamically to the mean interaction energy of the composite system. The evolution equation for the quasi-temperature is derived using the energy conservation law. Thus long-living dynamical correlations, which are associated with this conservation law and play an important role in transition to the Markovian regime and subsequent equilibration of the system, are properly taken into account.
NA61/SHINE Experiment—Program beyond 2020
Authors: Turko Ludwik
Published: November 2018

The fixed-target NA61/SHINE experiment (SPS CERN) looks for the critical point (CP) of strongly interacting matter and the properties of the onset of deconfinement. It is a scan of measurements of particle spectra and fluctuations in proton–proton, proton–nucleus, and nucleus–nucleus interactions as a function of collision energy and system size. This gives unique possibilities to researching critical properties of the dense hot hadronic matter created in the collision process. New measurements and their objectives, related to the third stage of the experiment after 2020, are presented and discussed here.
Flurbiprofen-Loaded Solid SNEDDS Preconcentrate for the Enhanced Solubility, In-Vitro Dissolution and Bioavailability in Rats
Authors: Kim Rae Man , Jang Dong-Jin , Kim Yu Chul , Yoon Jin-Ha , Min Kyoung Ah , Maeng Han-Joo , Cho Kwan Hyung
Published: November 2018

The aim of this work was to prepare and optimize a solid self-nanoemulsifying drug delivery system pre-concentrate (SSP) containing water-insoluble flurbiprofen (FL) using a novel pseudo-ternary phase diagram. The pseudo-ternary phase diagram, composed of FL as the drug and dispersion core, Kollisolv MCT 70 as the oil phase, and TPGS (tocopherol polyethylene glycol 1000 succinate) as the surfactant, was constructed for the determination of the SSP region. SSP was investigated in terms of particle size, physical state by differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD), in vitro dissolution and oral pharmacokinetics in rats. The determined SSP (FL/Kollisolv MCT 70/TPGS = 10/10/80, weight %) in the pseudo-ternary phase diagram had the melting point of 32.37 °C and uniform mean particle size of below 30 nm without any precipitation of FL in the dispersion. In the dissolution test, the SSP exhibited 95.70 ± 3.40% of release at 15 min, whereas the raw FL showed poor dissolution (i.e., 6.75 ± 1.30%) at that time point. In addition, the SSP showed the enhanced oral absorption (i.e., 1.93-fold increase in AUCinfinite) as compared to the suspension group of raw FL. Therefore, the developed SSP would be a promising drug delivery system with excellent solubilization, dissolution, and bioavailability for FL.
Effects of Fabric Counts and Weave Designs on the Properties of Laminated Woven Kenaf/Carbon Fibre Reinforced Epoxy Hybrid Composites
Authors: Aisyah H.A. , Paridah M.T. , Khalina A. , Sapuan S.M. , Wahab M.S. , Berkalp O.B. , Lee C.H. , Lee S.H.
Published: November 2018

The effects of different fabric materials namely weave designs (plain and satin) and fabric counts (5 × 5 and 6 × 6) on the properties of laminated woven kenaf/carbon fibre reinforced epoxy hybrid composites were evaluated. The hybrid composites were fabricated from two types of fabric, i.e., woven kenaf that was made from a yarn of 500tex and carbon fibre, by using vacuum infusion technique and epoxy resin as matrix. The panels were tested for tensile, flexural, and impact strengths. The results have revealed that plain fabric is more suitable than satin fabric for obtaining high tensile and impact strengths. Using a fabric count of 5 × 5 has generated composites that are significantly higher in flexural modulus as compared to 6 × 6 which may be attributed to their structure and design. The scanned electron micrographs of the fractured surfaces of the composites demonstrated that plain woven fabric composites had better adhesion properties than satin woven fabric composites, as indicated by the presence of notably lower amount of fibre pull out.
Wheat Germ Drying with Different Time-Temperature Combinations in a Fluidized Bed Dryer
Authors: Chan Der-Sheng , Kuo Meng-I
Published: November 2018

The development of an effective drying performance of the fluidized bed dryer (FBD) is crucial to reduce drying costs. The objective of this study was to investigate the drying performance of wheat germ (WG) with different time-temperature combinations in the FBD. The WG was dried at different set temperatures of 80, 100 and 120 °C. The moisture content (MC) and water activity (WA) of WG were measured. A mathematical model was proposed to develop an optimal drying condition. The changes in the MC of WG during drying in the FBD could be divided into the decreased period, the dynamic equilibrium period and the increased period. The product temperature of 45 °C and WA of 0.3 of WG drying could be attained by different time-temperature combinations. The mathematical model, which was developed in conjunction with different time-temperature combinations, could predict the dehydration time and the condensation time of WG for optimization the drying conditions. The WG dehydration at the heating stage and the WG condensation at the cooling stage could also be evaluated by the dehydration flux and the condensation flux, respectively. The optimal drying performance of WG exists in a compromise between promoting dehydration and reducing condensation. Information obtained from the analysis of dehydration flux and condensation flux with experimental data and simulation gave the guidelines for performing an effective drying of WG in the FBD.
A Random Forest-Based Approach to Map Soil Erosion Risk Distribution in Hickory Plantations in Western Zhejiang Province, China
Authors: Cheng Zhenlong , Lu Dengsheng , Li Guiying , Huang Jianqin , Sinha Nibedita , Zhi Junjun , Li Shaojin
Published: November 2018

Increasing agroforestry areas with improper management has produced serious environmental problems, such as soil erosion. It is necessary to rapidly predict the spatial distribution of such erosion risks in a large area, but there is a lack of approaches that are suitable for mountainous regions. The objective of this research was to develop an approach that can effectively employ remotely-sensed and ancillary data, to map soil erosion risks in an agroforestry ecosystem in a mountainous region. This research employed field survey data, soil-type maps, digital elevation model data, weather station data, and Landsat imagery, for extraction of potential variables. It used the random forest approach to identify eight key variables—slope, slope of slope, normalized difference greenness index at leaf-on season, soil organic matter, fractional vegetation at leaf-on season, fractional soil at leaf-off season, precipitation in June, and percent of soil clay—for mapping soil erosion risk distribution in hickory plantations in Western Zhejiang Province, China. The results showed that an overall accuracy of 89.8% was obtained for three levels of soil erosion risk. Approximately one-fourth of hickory plantations were at high-risk, requiring the owners or decision makers to take proper measures to reduce the soil erosion problem. This research provides a new approach to predict soil erosion risk, based on the primary variables that can be extracted directly from remotely-sensed data and ancillary data. This proposed approach will be valuable for other agroforestry and plantations, such as Torreya grandis, eucalyptus, and the rubber tree, that are playing important roles in improving economic conditions for the local farmers but face soil erosion problems.
A Ship Rotation Detection Model in Remote Sensing Images Based on Feature Fusion Pyramid Network and Deep Reinforcement Learning
Authors: Fu Kun , Li Yang , Sun Hao , Yang Xue , Xu Guangluan , Li Yuting , Sun Xian
Published: November 2018

Ship detection plays an important role in automatic remote sensing image interpretation. The scale difference, large aspect ratio of ship, complex remote sensing image background and ship dense parking scene make the detection task difficult. To handle the challenging problems above, we propose a ship rotation detection model based on a Feature Fusion Pyramid Network and deep reinforcement learning (FFPN-RL) in this paper. The detection network can efficiently generate the inclined rectangular box for ship. First, we propose the Feature Fusion Pyramid Network (FFPN) that strengthens the reuse of different scales features, and FFPN can extract the low level location and high level semantic information that has an important impact on multi-scale ship detection and precise location of dense parking ships. Second, in order to get accurate ship angle information, we apply deep reinforcement learning to the inclined ship detection task for the first time. In addition, we put forward prior policy guidance and a long-term training method to train an angle prediction agent constructed through a dueling structure Q network, which is able to iteratively and accurately obtain the ship angle. In addition, we design soft rotation non-maximum suppression to reduce the missed ship detection while suppressing the redundant detection boxes. We carry out detailed experiments on the remote sensing ship image dataset, and the experiments validate that our FFPN-RL ship detection model has efficient detection performance.
Rockfall Simulation Based on UAV Photogrammetry Data Obtained during an Emergency Declaration: Application at a Cultural Heritage Site
Authors: Sarro Roberto , Riquelme Adrián , García-Davalillo Juan Carlos , Mateos Rosa María , Tomás Roberto , Pastor José Luis , Cano Miguel , Herrera Gerardo
Published: November 2018

In recent years, there was an increasing number of studies focusing on rockfalls due to their impacts on social and sustainable development. This work carries out a three-dimensional (3D) simulation of rockfalls at a cultural heritage site nearby the village of Cortes de Pallás (Valencian Community, East Spain). The simulation is based on data collected previously, during an emergency declaration due to the occurrence of a considerable rockfall (7980 m3) on the southern bank of the Cortes de Pallás reservoir, on 6 April 2015. The hydroelectric power plant was damaged, and the main access road to the village of Cortes de Pallás was blocked for eight months. The predominant discontinuities of the rock mass were analyzed by means of the application of structure from motion (SfM) photogrammetry techniques to the set of images taken by remotely piloted aircraft systems (RPAS). The average size of the block was determined as 3.2 m in diameter and 17.6 m3 in volume. Additionally, a digital elevation model (DEM) was generated from an aerial laser scanning (ALS)-derived point cloud using a 1 × 1 grid. These data were implemented in RocPro3D software, obtaining the distances traveled by the blocks detached from different source areas at a cultural heritage site located near the rockfall event, which presents the same geological context. The simulation presented herein shows aggravating circumstances that endanger the cultural heritage area, with higher rockfall hazards than previous official studies (1991) displayed.
A Compressive Sensing-Based Approach to Reconstructing Regolith Structure from Lunar Penetrating Radar Data at the Chang’E-3 Landing Site
Authors: Wang Kun , Zeng Zhaofa , Zhang Ling , Xia Shugao , Li Jing
Published: November 2018

Lunar Penetrating Radar (LPR) is one of the important scientific systems onboard the Yutu lunar rover for the purpose of detecting the lunar regolith and the subsurface geologic structures of the lunar regolith, providing the opportunity to map the subsurface structure and vertical distribution of the lunar regolith with a high resolution. In this paper, in order to improve the capability of identifying response signals caused by discrete reflectors (such as meteorites, basalt debris, etc.) beneath the lunar surface, we propose a compressive sensing (CS)-based approach to estimate the amplitudes and time delays of the radar signals from LPR data. In this approach, the total-variation (TV) norm was used to estimate the signal parameters by a set of Fourier series coefficients. For this, we chose a nonconsecutive and random set of Fourier series coefficients to increase the resolution of the underlying target signal. After a numerical analysis of the performance of the CS algorithm, a complicated numerical example using a 2D lunar regolith model with clipped Gaussian random permittivity was established to verify the validity of the CS algorithm for LPR data. Finally, the compressive sensing-based approach was applied to process 500-MHz LPR data and reconstruct the target signal’s amplitudes and time delays. In the resulting image, it is clear that the CS-based approach can improve the identification of the target’s response signal in a complex lunar environment.
A Polarization Independent Quasi-TEM Metamaterial Absorber for X and Ku Band Sensing Applications
Authors: Hoque Ahasanul , Tariqul Islam Mohammad , Almutairi Ali F. , Alam Touhidul , Jit Singh Mandeep , Amin Nowshad
Published: November 2018

In this paper, a dual-band metamaterial absorber (MMA) ring with a mirror reflexed C-shape is introduced for X and Ku band sensing applications. The proposed metamaterial consists of two square ring resonators and a mirror reflexed C-shape, which reveals two distinctive absorption bands in the electromagnetic wave spectrum. The mechanism of the two-band absorber particularly demonstrates two resonance frequencies and absorption was analyzed using a quasi-TEM field distribution. The absorption can be tunable by changing the size of the metallic ring in the frequency spectrum. Design and analysis of the proposed meta-absorber was performed using the finite-integration technique (FIT)-based CST microwave studio simulation software. Two specific absorption peaks value of 99.6% and 99.14% are achieved at 13.78 GHz and 15.3 GHz, respectively. The absorption results have been measured and compared with computational results. The proposed dual-band absorber has potential applications in sensing techniques for satellite communication and radar systems.
A Study of Automatic and Real-Time Table Tennis Fault Serve Detection System
Authors: Hung Chang-Hung
Published: November 2018

Calling a table tennis fault serve has never been easy for umpires, since they can only rely on their intuition. This study presents an algorithm that is able to automatically find the positions of the ball and racket in the images captured by high-speed camera. The trajectory of ball toss is analyzed and the result can be used as the objective basis for the umpire to decide if the serve is legal. This algorithm mainly consists of YCbCr color space processing, morphological processing method, circle Hough transform application, separation of moving and static components in an image sequence using the stable principal component pursuit method. The experiment results show that YCbCr color space provides better performance than HSV color space in recognizing the ball color close to skin tone. It is also demonstrated that the positions of the ball and racket can be successfully located by using the methods of color segmentation and stable principal component pursuit. Lastly, it is hoped that this study will provide more useful information regarding how to identify illegal ball toss in tennis ball game using image processing techniques to other researchers.