bluuebunny/crossref_metadata_2025 huggingface dataset:
Polyamines of biological fluids of the body and the diagnostic value of their determination in clinical and laboratory researches (review of literature)
Authors: Ploskonos M. V.
Published: April 2021

The review provides the analysis of the content of the main polyamines (PA) - spermine, spermidine and putrescine in the most important biological fluids of the human body (blood, urine, seminal fluid, etc.). The assessment of their diagnostic and prognostic value in clinical practice is carried out. The novelty and value of assessing of the level of PA metabolites as new diagnostic markers of various diseases has been shown. Among such diseases as cancer, stroke, renal failure, for which the search for early markers is especially relevant. This survey data can be of practical interest and taken into account in estimating the level of PA and its derivatives in clinical and laboratory reseaches. The literature search for the review was carried out using the Scopus, Web of Science, MedLine, RSCI databases.
HEDONISME KRISTEN JOHN PIPER SEBAGAI SEBUAH KONTEKSTUALISASI DI DALAM IMAN KRISTEN
Authors: Rusli Rusli
Published: April 2021

?Iman Kristen selalu menghadapi tantangan di dalam setiap zaman, tetapi tugas penting yang harus dikerjakan tidak pernah berubah,?yaitu bagaimana menaklukkan zaman di dalam kebenaran Tuhan. Setelah bergumul dalam zaman modern, iman Kristen menghadapi tantangan lainnya di dalam zaman postmodern. Pandangan John Piper yang dikenal dengan hedonisme Kristen lahir di tengah-tengah tantangan "self-seeking pleasure" dalam zaman postmodern. Meskipun pandangan ini telah menjadi berkat besar di dalam kekristenan, namun kritik dan kontradiksi juga tidak terhindarkan ditujukan kepada Piper. Perhatian dan keberatan yang muncul berkenaan dengan pertanyaan apakah Piper mengkompromikan kebenaran Firman Tuhan dengan situasi dunia berdosa. Pembahasan akan menunjukkan bahwa pandangan Piper bukan suatu kompromi, melainkankontekstualisasi dan apa yang Piper kerjakan senantiasa berpegang pada kebenaran Kristen dengan relevansi dan kesetiaan kepada berita Injil.
Editorial
Authors: Un Antonius
Published: April 2021

Editorial
COVİD-19 KRİZİNİN DİPLOMASİYE ETKİSİ VE ULUSLARARASI SİSTEM’DE ARTAN BELİRSİZLİKLER
Authors: KOÇ Engin
Published: April 2021

Bu çalışmada, Covid-19’un diplomasi ve uluslararası sisteme yansımalarının mevcut ve gelecekteki olası etkileri incelenmiştir. Mart 2020’den itibaren Çin merkezli Covid-19 salgını küresel krize dönüşmüş ve hızlı bir şekilde bütün dünyayı etkisi altına almıştır. Uluslararası kuruluşların bu küresel krizi çözmede kapasitelerinin yetersizliği ve kuruluş ilkelerini karşılayacak özerk bir yapıya sahip olmaması; bu kuruluşlara yönelik eleştirilerin artmasına neden olmuştur. Ayrıca bu süreçte uluslararası kuruluşların güven kaybetmesi uluslararası ilişkilerde daha gerçekçi ve devlet merkezli bir dönemin başlayacağına işaret etmektedir. Bununla beraber, mevcut salgın krizi sadece BM, DTÖ ve AB gibi uluslararası kuruluşların ortak rollerini zayıflatmakta, aynı zamanda dünyanın birçok yerinde milliyetçi hareketleri de güçlendirmektedir.
Bottom water oxygenation changes in the Southwestern Indian Ocean as an indicator for enhanced respired carbon storage since the last glacial inception
Authors: Amsler Helen Eri , Thöle Lena Mareike , Stimac Ingrid , Geibert Walter , Ikehara Minoru , Kuhn Gerhard , Esper Oliver , Jaccard Samuel Laurent
Published: April 2021

Abstract. We present downcore records of redox-sensitive authigenic uranium (U) and manganese (Mn) concentrations based on five marine sediment cores spanning a meridional transect encompassing the Subantarctic and the Antarctic zones in the Southwest Indian Ocean covering the last glacial cycle. These records signal lower bottom water oxygenation during glacial climate intervals and generally higher oxygenation during warm periods, consistent with climate-related changes in deep ocean remineralised carbon storage. Regional changes in the export of siliceous phytoplankton to the deep-sea may have entailed a secondary influence on oxygen levels at the water-sediment interface, especially in the Subantarctic Zone. The rapid reoxygenation during the deglaciation is in line with increased ventilation and enhanced upwelling after the Last Glacial Maximum (LGM), which, in combination, conspired to transfer previously sequestered remineralised carbon to the surface ocean and the atmosphere, contributing to propel the Earth’s climate out of the last ice age. These records highlight the yet insufficiently documented role the southern Indian Ocean played in the air-sea partitioning of CO2 on glacial-interglacial timescales.
Integrating Agricultural Practices into the TRIPLEX-GHG Model v2.0 for Simulating Global Cropland Nitrous Oxide Emissions: Model Development and Evaluation
Authors: Song Hanxiong , Peng Changhui , Zhang Kerou , Zhu Qiuan
Published: April 2021

Abstract. Nitrous oxide (N2O) emissions from croplands are one of the most important greenhouse gas sources, and it is difficult to simulate on a large scale. In order to simulate N2O emissions from global croplands, a new version of the process-based TRIPLEX-GHG model was developed by coupling the major agricultural activities. The coefficient of the NO3− consumption rate for denitrification (COEdNO3) was found to be the most sensitive parameter based on sensitivity analysis, and it was calibrated using field data from 39 observation sites across major croplands globally. The model performed well when simulating the magnitude of the daily N2O emissions and was able to capture the temporal patterns of the N2O emissions. The COEdNO3 ranged from 0.01 to 0.05, and the continental mean of the parameter was used for the model validation. The validation results indicate that the means of the measured daily N2O fluxes during the experiment periods are highly correlated with the modeled results (R2 = 0.87). Consequently, our model simulation results demonstrate that the new version of the TRIPLEX-GHG model can reliably simulate N2O emissions from various croplands at the global scale.
Impact of frozen soil processes on soil thermal characteristics at seasonal to decadal scales over the Tibetan Plateau and North China
Authors: Li Qian , Xue Yongkang , Liu Ye
Published: April 2021

Abstract. Frozen soil processes are of great importance in
controlling surface water and energy balances during the cold season and in
cold regions. Over recent decades, considerable frozen soil degradation and
surface soil warming have been reported over the Tibetan Plateau and North
China, but most land surface models have difficulty in capturing the
freeze–thaw cycle, and few validations focus on the effects of frozen soil processes on soil thermal characteristics in these regions. This paper
addresses these issues by introducing a physically more realistic and
computationally more stable and efficient frozen soil module (FSM) into a
land surface model – the third-generation Simplified Simple Biosphere Model (SSiB3-FSM). To overcome the difficulties in achieving stable numerical
solutions for frozen soil, a new semi-implicit scheme and a physics-based
freezing–thawing scheme were applied to solve the governing equations. The performance of this model as well as the effects of frozen soil process on
the soil temperature profile and soil thermal characteristics were investigated over the Tibetan Plateau and North China using observation
sites from the China Meteorological Administration and models from 1981 to 2005. Results show that the SSiB3 model with the FSM produces a more realistic soil
temperature profile and its seasonal variation than that without FSM during
the freezing and thawing periods. The freezing process in soil delays the
winter cooling, while the thawing process delays the summer warming. The
time lag and amplitude damping of temperature become more pronounced with
increasing depth. These processes are well simulated in SSiB3-FSM. The
freeze–thaw processes could increase the simulated phase lag days and land memory at different soil depths as well as the soil memory change with the soil thickness. Furthermore, compared with observations, SSiB3-FSM produces
a realistic change in maximum frozen soil depth at decadal scales. This study shows that the soil thermal characteristics at seasonal to decadal scales
over frozen ground can be greatly improved in SSiB3-FSM, and SSiB3-FSM can be used as an effective model for TP and NC simulation during cold season. Overall, this study could help understand the vertical soil thermal
characteristics over the frozen ground and provide an important scientific
basis for land–atmosphere interactions.
About the return period of a catastrophe
Authors: Raschke Mathias
Published: April 2021

Abstract. To understand catastrophes like earthquakes stochastically, their return period (RP) should be quantified for the concerned region. Measures such as event magnitudes or indexes are less helpful for this purpose. We derive the combined return period (CRP) from the pseudo-polar coordinates of extreme value theory. The CRP is the (weighted) mean of local RPs and is again an RP; other metrics do not provide such testable reproductivity. We demonstrate CRP’s opportunities on extratropical cyclones (winter storms) over Germany, including validation and bias correction of local RP estimates. Furthermore, we introduce new estimation methods for the RP of an event loss (risk curve) via CRP-scaling of historical storm fields. For high RP, the resulting event losses of the German insurance market are higher in the case of max-stable dependence. The latter means the same dependence level between local maxima of a year as of a decade. However, spatial dependence is not stable but decreases by increasing period. Such control of spatial dependence is not realized by previous risk models from science and industry. Our loss estimates for RP of 200 years are also significantly smaller than those of European regulation's standard model.
Statistical literacy and quantitative reasoning: Rethinking the curriculum
Authors:   Michigan State University, Burrill Gail
Published: April 2021

The importance of statistical literacy/quantitative reasoning has been highlighted for decades; today the need is even more compelling with data science emerging as foundational in many disciplines. Educated students should understand how to make decisions in the presence of uncertainty and how to interpret quantitative information presented to them in the course of their professional and personal activities. Too often, however, students have limited experience in thinking and reasoning based on real data. This paper explores how ideas from data science interface with notions of statistical literacy/quantitative reasoning, considers foundational concepts necessary to enable students to engage with real data sets in the learning process, and identifies potential curricular elements that are important for all students from these perspectives.
Challenges for the smartification of Kazakhstan cities: evolution of models of city development governance in the framework of democratization
Authors: Mendybayev Birlik , BURBAYEVA Perizat , OTAR Elmira
Published: April 2021

Urban governance is a multidimensional process, based on planning, allocation of limited resources, implementation of current and investment tasks, monitoring and control. The management processes involve stakeholders with different interests, role, and degree of involvement in management. At the institutional level, there are central government organizations that provide the parameters of urban policy on a country scale, city politicians and managers responsible for managing all urban systems and the citizens themselves. The inconsistency of interests and plans reduces the attractiveness of the city, can lead to an increase in the cost of living, an outflow of population. This article discusses how the concept of a smart city can affect the quality of management and improve the quality of decisions. Case of Kazakhstan cities allows us to conclude that the quality of management and interaction of participants affects the sustainability of the city's development in all areas of development. Good governance affects economy, lifestyle and living conditions, attractiveness for living. In turn, new opportunities used by citizens to influence policies create the sustainability in city's development.
HYBRID THREATS TO GLOBAL SECURITY
Authors: OSTROVSKA Iryna
Published: April 2021

This article examines the phenomenon of the influence of hybrid threats on global world security in the modern conditions of globalization and the information and communication revolution. In particular, it is argued that hybrid wars have become a new type of interstate confrontation for solving military-political problems. Conflict events in post-Soviet Ukraine are considered as an example, leading to the emergence of new risks for an individual and society as a whole. At the end of the article, the author concludes that the conflict events in Ukraine, after gaining independence, have a significant impact on global security in the world. And although Ukraine is carrying out attempts to confront hybrid wars, the threats continue to be relevant, which poses the same challenges for the entire world society to counter.
Women's Awareness Level on Breast Self-Examination
Authors: Akbaş Güneş Nurcan , Aypak Cenk , Özdemir Çağla , Gorpelioglu Suleyman
Published: April 2021

Aim: The aim of this study was to investigate the level of awareness, regarding the importance of breast self examination (BSE), clinical breast examination (CBE) and mammography, and the effects of education on these issues among patients who applied to family medicine outpatient clinic for follow-up or treatment purposes.Methods: This study was done by establishing a questionnaire form, after review of necessary litetarure, to be applied in patients who applied for follow-up or treatment in a district polyclinic affiliated to the department of family medicine of a tertiary care center in Ankara.Results: A total of 434 women aged between 18-56 years participated in the study. The mean age of the participants was 36.62±9,21 years. Although 258 (59.4%) of the participants reported that they performed BSE. 176 participants (40.6%) stated that they did not perform a BSE. The 38.2% of the participants have undergone a CBE and the 24 % of women expressed that they underwent a mammography.The frequency of BSE, CBE and undergoing mammography has been shown to increase significantly as education level increases. The rates of having a CBE and a mammography were also found to be statistically significantly higher in patients who had a family member with breast cancer.Conclusion: Our results demonstrated that the level of education was important for awareness on the early diagnosis of breast cancer. Thanks to efforts to increase educational level, we can get promising achievements regarding the awareness of both BSE, CBE and mammography performances.
PENGARUH PEMBERIAN SARI KEDELAI TERHADAP PENURUNAN TEKANAN DARAH PADA PENDERITA HIPERTENSI DI RW 01 DESA SUKODONO KECAMATAN PUJER BONDOWOSO
Authors: Tyas Eka Suryaning , Mukhofi Lutfi
Published: April 2021

Penyakit darah tinggi yang berkembang saat ini belum tentu di ketahui oleh penderitanya karena kadang-kadang penyakit darah tinggi tidak memunculkan gejala-gejala atau keluhan-keluhan sehingga di sebut the silent killer. Adaput pengobatan hipertensi secara farmakologis dapat menimbulkan efek samping pada penggunanya, sehingga menyebabkan masyarakat memilih buah dan sayuran sebagai alternatif pengobatan hipertensi, salah satunya dengan terapi sari kedelai. Sari kedelai merupakan minuman yang bergizi tinggi,terutama dengan kandungan proteinnya. Selain itu sari kedelai juga mengandung lemak, karbohidrat, kalsium, mineral magnesium, phospor, zat besi, provitamin A, vitamin B komplek dan air. Tujuan penelitian ini adalah untuk menganalisis pengaruh pemberian sari kedelai terhadap penurunan tekanan darah pada penderita hipertensi di RW 01 Desa Sukodono kecamatan Pujer Bondowoso.
HUBUNGAN FAKTOR LINGKUNGAN DENGAN KEJADIAN ISPA PADA BALITA DI SUSUN LOR DESA RAMBI GUNDAM KECAMATAN RAMBI PUJI KABUPATEN JEMBER
Authors: Suryaningtyas Eka
Published: April 2021

Lingkungan adalah kombinasi antra kondisi fisik yang mencakup keadaan sumber daya alam seperti tanah, air, energi surya, minerl serta flora dan fauna yang tumbuh di Atas tanah maupun lautan, dengan kelembapan yang meliputi ciptaan manusia di sebabkan oleh: (1) faktor demografi, (2) faktor biologis (3) faktor polusi (4) faktor timbulnya penyakit. Pada penelitian ini mempunyai tujuan mengetahui hubungan faktor Lingkungan dengan kejadian ISPA di dusun Lor desa Rambigundam .Penelitian ini merupakan desain korelasi, untuk menentukan sampel, menggunakan  sampel random sejumlah 31 responden, alat pngukuran data mengunakan lembar observasi yang di lakukan pada tanggal 10 April Di dusun Kerajan Lor desa Rambigundam kecamatan Rambipuji Jember.

Pengolahan data meliputi: editing, coding, entry, scoring, trublating, kemudian data di analisa mengunakan wilcoxson. Hasil dari pengolahan data di peroleh sebagian besar responden mempunyai lingkungan yg cukup baik sebanyak 21 responden (68%), dari Data riwayat ISPA sebagian besar responden pernah mengalami ISPA  sebanyak 22 Responden (71%), maka di peroleh hasil p value: 0,000  a=o,o5 sehinga di simpulkan H1 di terima, artinya adalah hubungan faktor lingkungan dengan kejadian ISPA. Berdasarkan hasil penelitian di harapkan respon dapat menjaga kebersihan lingkungan,  dengan cara menjaga kebersihan lingkungan maka responder akan terhindar Dari penularan ISPA.
Hubungan Keteraturan Antenatal Care pada Ibu Hamil Trimester III dengan Kejadian Pre Eklamsia di Puskesmas Banjarsengon kabupaten Jember.
Authors: Nur Perdani Ayu Puteri
Published: April 2021

Antenatal care is one form of health services for pregnant women which if done regularly can reduce both maternal and infant mortality rates, by conducting regular antenatal care it is expected that pregnant women and fetuses can be monitored for their development by health workers. This study aims to determine the relationship of regular antenatal care in third trimester pregnant women with the incidence of Pre-eclampsia in Banjarsengon Health Center, Jember Regency. This study uses a quantitative research design with a cross-sectional approach. Respondents in this study were 20 people with purposive sampling data collection techniques. Data were analyzed using exact fisher. The results of this study found that there is a relationship between regular Antenatal care in Trimester III pregnant women with the incidence of Pre-Eclampsia.
PENGARUH STORY TELLING TERHADAP KEPUTUSASAAN REMAJA DENGAN KONDISI TAKOTSUBO CARDIOMYOPATHY (BROKEN HEART SYNDROME) DI JEMBER
Authors: Azari Abdul Aziz
Published: April 2021

Pendahuluan: Remaja selalu dihadapkan pada persoalan keputusasaan, terutama remaja yang mengalami broken heart syndrome . Tujuan dari penelitian ini adalah untuk mengetahui pengaruh story telling terhadap keputusasaan remaja dengan kondisi broken heart syndrome. Metode: Jenis penelitian ini adalah dengan pendekatan quasi eksperimen. Pengumpulan data dilakukan dengan memberikan kuesioner pre dan post intervensi. Penelitian ini menggunakan purposive sampling, dengan jumlah sampel 6 remaja yang mengalami broken heart syndorme. Data dikumpulkan dengan menggunakan kuesioner dan dianalisis dengan Chi Square test. Hasil: Hasil penelitian menunjukan bahwa sebelum dilakukan intervesi story telling sebagian besar responden mengalami keputusasaan sebesar 67%, setelah dilakukan tindakan responden tidak mengalami keputusasaan sebesar 67%. Sedangkan hasil chi square didapatkan nilai alfa 0,00 yang artinya ada pengaruh story telling dengan keputusasaan remaja dengan kondisi broken heart syndrome. Rekomendasi: Perlu dilakukan pengkajian dan pendekatan lebin lanjut tentang kondisi remaja yang mengalami broken heart syndorme dikarenakan bisa menyebabkan terjadinya masalah psikologis yang lebih besar, misalnya depresi.
Pengalaman Psikologis Ketidakberdayaan Post COVID-19 di Jember (Studi Kasus)
Authors: Azari Abdul Aziz
Published: April 2021

Introduction: Helplessness is a condition in which the individual feels unable to endure all painful and uncomfortable things that support himself. In people with post-Covid-19, the helplessness they experience tends to be the signs and symptoms they experience when suffering from Covid-19. This study aims to describe the helplessness of Covid-19 patients as long as they are attacked by Covid-19. Methods: This study used a qualitative research design with a case study approach. Participants in the study were 1 person with purposive sampling data collection technique. Data analysis using Colaizzi technique. Results: Based on the research conducted, there were several manifestations of helplessness presented by Covid-19 sufferers, emotional, motivational and behavioral symptoms; where it all decreases and affects a person's depression. Discussion: The experience of suffering from Covid-19 provides traumatic experiences for sufferers, one of which is helplessness during the Covid-19 treatment period, and this results in changes in the emotional, cognitive, and behavior of someone who has suffered from Covid-19.

Keywords: helplessness, Covid-19, psychological, depression.
Aplikasi Data Gudang Sparepart Pada Toko Prima Jaya Aek Nabara Menggunakan Visual Basic.Net
Authors: Kusmanto Kusmanto , Watrianthos Ronal
Published: April 2021

Pada saat ini proses pencatatan data persediaan barang pata Toko Prima Jaya Aek Nabara masih dilakukan secara manual, terutama dalam hal pencatatan data masuk dan keluarnya barang serta pembuatan laporan-laporan. Dengan sistem seperti itu menyebabkan sering terjadinya kesalahan yang dapat berdampak pada persediaan barang secara keseluruhan. Dengan dibangunnya aplikasi ini akan membantu proses transaksi keluar dan masuknya barang agar lebih efisien. Dalam membangun aplikasi menggunakan Visual Basic.Net 2008. Apabila aplikasi ini digunakan maka diharapkan dapat mempermudah memberikan informasi kepada pimpinan dan laporan yang dihasilkan merupakan data yang efektif.
MONITORING OF PRINCIPAL FACTORS OF BACTERIAL HAZARDS IN THE INDUSTRIAL RODUCTION OF CHICKEN FOOD GRADE EGGS
Authors: Demyanenko D. V. , Vashchik E. V.
Published: April 2021

In the production of poultry products, special attention is paid to diseases the causative agents of which are common for poultry and humans; as far as poultry products contaminated with pathogenic and opportunistic microor-ganisms are a potential source of infections, toxic infections and toxicoses in humans. We studied the bacterial risks at all main stages of the industrial production of chicken food grade eggs and, the main critical control points of production were defined in compliance with the principles of the HACCP system.
THE INFLUENCE OF A COMPLEX APIPREPARATION “APHRODITE” ON BLOOD PARAMETERS OF PREGNANT COWS
Authors: Duda Yu. V. , Koreyba L. V. , Garaschuk M. I. , Slesarenko V. V.
Published: April 2021

The findings show that in deep pregnant cows of the Red Steppe breed changes of biochemical values of blood were mild; however, the acid-base imbalance, disturbance in mineral and protein metabolism, and a decrease in the carotene status were detected.
The use of the apipreparation “Aphrodite” for prophylactic purposes contributed to the increase in the calcium level by 1.11 times, immunoglobulin M by 1.28–1.48 times, and lysozyme activity by 14.46%. Therefore, this preparation showed a pronounced immune stimulating effect.
Endophragmiella spp. nov. and new records from southern China
Authors: Ma Jian , Ma Li-Guo , Xu Zhao-Huan , Cui Ru-Qiang , Qiu Ling , Castañeda-Ruíz Rafael F. , Zhang Xiu-Guo
Published: April 2021

Four new species—Endophragmiella chinensis, E. guangdongensis, E. lushanensis, and E. obovoidea—collected on dead branches of unidentified plants in southern China, are described, illustrated, and compared with closely related species. From the
same habitat, three other species, E. cantabrica, E. ellisii, and E. uniseptata are recorded from China for the first time.
Myxomycetes in the Pantanal biome: first records and a new associate, Attalea phalerata
Authors: Moreira Izabel Cristina , Leonardo-Silva Lucas , Ferreira-Sá Antônio Sérgio , Xavier-Santos Solange
Published: April 2021

The occurrence of myxomycetes is reported for the first time in the Brazilian Pantanal and on Attalea phalerata (acuri palm). The records are based on sporocarp collections made in the municipality of Poconé, State of Mato Grosso, in an area characterized by seasonal hydrological
fluctuations and naturally open areas. We report six species: Arcyria obvelata, Perichaena depressa, and P. vermicularis (Trichiaceae); and Physarum album, P. compressum, and P. polycephalum (Physaraceae), all of which represent new records
for the Pantanal and a new substrate, A. phalerata.
Gerronema nemorale: first report of the genus and species from Pakistan
Authors: Aqdus Fauzia , Khalid Abdul Nasir
Published: April 2021

Basidiomata of a Gerronema species, collected in Murree, Punjab, Pakistan, have been confirmed as G. nemorale by morphological and ITS1-5.8S-ITS2 rDNA sequence analyses. This is the first report of the genus Gerronema from Pakistan, and the first record of G.
nemorale for the South Asian region.
Smardaea isoldae sp. nov. from a tropical cloud forest in Mexico
Authors: Raymundo Tania , Valenzuela Ricardo
Published: April 2021

Smardaea isoldae is described from Sierra Madre Oriental, Hidalgo State, Mexico. The new species is distinguished by its olivaceous coloration, habit on dead wood, and tropical cloud forest habitat. The holotype is deposited in ENCB Herbarium. A key to Smardaea species
is presented.
Study of Nidanpanchak , Ayurvedic Management and Pathya – Apathya of Kushtha (Skin Diseases )
Authors: Shashikant Shashikant  Laturkar
Published: April 2021

Skin is outermost covering of the body. Its function as antimicrobial and chemical barrier, and protects body from a number of external hazards. In Ayurveda, skin diseases are described in various texts. Cause of the skin disease is vitiation of tridosha and dhatus in ayurvedic text. Total 166 skin diseases are described in brahttrie. Out of 166 skin diseases, 22 are vata prominent, 24 are pitta prominent, 21 are kapha prominent, 18 are raktaja, 10 are vata pitta prominent,10 are pitta kapha prominent, 17 are vata kapha prominent, 14 are tridoshaja, 13 are agantuj (external causes), and other 17 skin diseases. Although most of skin diseases are described under the kushtha and kshudraroga but description of some other skin diseases is also described under headings of bahaya visarpa, vidradhi, shotha,  nanatmaja vyadhi, shukaroga, granthi arbuda, upadansh and shilipada.  Allergic conditions which are not included in any of these are described as udarda- kotha-uattkotha.
A “A COMPARATIVE STUDY OF ASITAKADI CHURNA AND ALAMBUSADI CHUNA IN THE MANAGEMENT OF AMAVATA”
Authors: KANDIKATTIWAR Dr.PRIYANKA
Published: April 2021

ABSTRACT: - INTRODUCTION: - Amavata is one of the challenging diseases for the physicians due to its chronic nature, difficulty, complications. Amavata is the prime disease which makes the person unfit for an independent life. In this study, Asitakadi Churna  and Alambusadi chuna are considered, as both the drugs possess Vata-Kaphahara and Amapachak properties. Here an attempt is made to compare the efficacy of Asitakadi Churna  and Alambusadi chuna in Amavata with the title “A Comparative study of Asitakadi Churna  and Alambusadi chuna in the management of Amavata” AIM & OBJECTIVE: - To compare effect of Alabushadi churna  and Asitakadi churna in Amavata. MATERIALS AND METHODS - The patients were selected from the OPD and IPD of concern institution. 60 patients of Amavata were randomly selected and divided into two groups of 30 patients each, and subjected to clinical trial. Group- A patients were treated with Asitakadi Churna  and Group-B patients were treated with Alambusadi chuna. The signs and symptoms were recorded on the preformed designed for the study and assessment was done on subjective and objective criteria and results were analyzed statistically. RESULT – In the present study, it is concluded that both Group A and Group B showed significance in decreasing shool, Shoth, gourava, and jadya. Asitakadi Churna  is equally effective as Alambusadi chuna in on  Amavata. CONCLUSION – The treatments were found to be statistically significant in reducing the signs and symptoms of the disease.
Experience in teaching cancer alertness to primary care doctors in the Republic of Kazakhstan
Authors:   JSC ", BAZARBAYEVA A.A. ,   Scientific Center Center of Pediatrics and Pediatric Surgery", BORANBAYEVA R.Z. ,   JSC "Scientific Center Center of Pediatrics and Pediatric Surgery", MANZHUOVA L.N. ,   JSC "Scientific Center Center of Pediatrics and Pediatric Surgery", SHAKHMETOVA K.S. ,   JSC "Scientific Center Center of Pediatrics and Pediatric Surgery", ABDILOVA G.K. ,   JSC "Scientific Center Center of Pediatrics and Pediatric Surgery", NURZHANOVA G.A. ,   JSC "Scientific Center Center of Pediatrics and Pediatric Surgery"
Published: April 2021

Relevance: Malignant neoplasms (MN) lead the structure of childhood mortality worldwide. At that, most cases are detected at advanced stages. Early diagnostics is required to improve treatment outcomes in children with cancer. The success mainly depends on oncological alertness and knowledge of primary care doctors. The study aimed to analyze the results of training primary care doctors in early diagnostics of oncological and hematological diseases in children using MN staging. Results: The paper shares the experience of teaching primary care doctors on early diagnostics of oncological and hematological diseases in children. The analysis used the patient data with staged diagnosed MNs. 3,092 primary care doctors were trained according to the programs we developed and implemented for training trainers and primary care and specialized doctors on early diagnostics of oncological and hematological diseases in children. The training of many primary care specialists has improved early children cancer detection rates. Thus, early cancer detection (stage I-II) in children has improved from 29% in 2015 to 37.2% in 2016, 38.2% in 2017, 40.3% in 2018, and 41.4% in 2019. Since 2020, early detection of MN in children prevails (53%). Conclusion: Despite the extensive experience and fairly good results comparable to international indicators, the problem of late cancer detection in children remains urgent since it worsens survival forecasts and increases the cost of treatment of oncohematological diseases in children. Keywords: malignant neoplasms (MN), early diagnostics, children, oncological diseases.
Utilizzo del protossido di azoto nella riduzione del dolore e dell’ansia da procedura in Pediatria
Authors: Di Cesare Merlone Alessandra , Martinelli Roberta , Molteni Ornella , Selicorni Angelo
Published: April 2021

Background - To prevent and control the procedural pain includes an adequate analgesia and the reduction of the anxiety/distress related to the procedure itself. A useful tool that combines the analgesic and sedative effects is nitrous oxide combined in different percentages with oxygen.
 Objective - The goal of this study is to evaluate the efficiency of the nitrous oxide in the management of procedural pain and distress in a paediatric environment, also considering the possibility that a pre-made solution of nitrous oxide and oxygen 50/50 could be given independently of the inmate by a properly trained nurse.
 Methods - An observational study at the Paediatric First Aid Department in Sant’Anna Hospital (Como, Italy) was performed by creating a special procedure that was applied to children older than 1 year old that needed to undergo low to mild painful procedures between July 6th 2017 and December 31st 2019. The blend was dosed by a demand valve. For each procedure a form was filled in with personal data, side effects, parameters and an evaluation of the pre-procedure and post-procedure pain. All the staff then took a satisfaction questionnaire.
 Results - The study corroborates that preblended nitrous oxide 50/50 is safe and efficient, and also guarantees analgesic and anxiolytic effects for a vast case of mildly painful procedures. The little use of other drugs and the absence of opioids in the treatment is likely the main reason for the absence of major side effects.
 Conclusions - The collected data suggest that a 50/50 blend of nitrous oxide and oxygen is still used considering its efficiency and manageability in the procedural sedation and also confirm that using the same concentrations and avoiding combination with opioids is safe and available to properly formed nurses.
IperCKemia asintomatica: la malattia di Pompe late-onset
Authors: Borelli Elena , Casciana Maria Luisa , Salemi Claudia , Sordelli Silvia , Fasoli Silvia
Published: April 2021

The paper reports the case of a 7-year-old boy who presented with elevated alanine and aspartate transaminases. Further investigations demonstrated elevated creatine kinase (CK), so an underlying metabolic disorder was investigated even in absence of clinical manifestations. Dried blood spot (DBS) screening test for acid α-glucosidase (AAG) enzyme activity was below normal levels and molecular genetic testing for AAG gene demonstrated pathogenic mutations. The diagnosis of late-onset Pompe disease (LOPD) was finally confirmed. Thanks to the early diagnosis, the child would be under close surveillance and would timely commence enzyme replacement therapy (ERT), improving the prognosis of the disease.
 The diagnostic delay in patients with LOPD is still common, namely between about 5 and 30 years. Clinicians need a high index of suspicion to recognize this condition as it is a rare disease and the heterogeneous clinical presentation can mimic the presentation of other neuromuscular disorders.
 Diagnostic laboratory tests are quite fast and reliable to detect the enzymatic deficiency and enzyme replacement therapy (ERT) is available and improves long-term outcomes. Thus, it is of absolute importance that clinicians should consider the possibility of LOPD in patients who present with asymptomatic hyperCKemia.
A EDUCAÇÃO 4.0: UM ESTUDO DE CASO ACERCA DA FORMAÇÃO DE PROFESSORES PARA ENFRENTAMENTO DOS DESAFIOS DO SÉCULO XXI
Authors: Lemes Isadora Luiz , Dos Santos Renato Pires
Published: April 2021

Este artigo apresenta um Estudo de Caso realizado em uma oficina voltada a Formação de Professores ocorrida no segundo semestre de 2019. Diante das tantas transformações que vêm acontecendo e envolvendo inúmeros segmentos da sociedade, a Educação não pode ficar à margem e ignorar que há necessidade em delinear estratégias e metodologias para que os professores estejam preparados e obtenham adequada formação de modo que os discentes atuem, futuramente, de forma ativa e consonante às necessidades e realidades do século XXI. Esta proposta teve por objetivo propiciar um momento de formação para professores, de modo a discutir, de forma inicial, as mudanças que se fazem mister e o que vêm sendo previsto envolvendo a Educação 4.0, enfocando no modo como se poderia pensar em adotar novas posturas, dando espaço para que o docente pudesse repensar e refletir acerca de seu papel no momento atual, bem como, sobre quais serão suas competências no contexto atual. A oficina realizou-se no ambiente de uma Universidade e era aberta a todos os professores, independente se atuavam na Educação Básica ou superior, ou mesmo para alunos das licenciaturas, que podiam manifestar interesse em participar mediante inscrição prévia. Um participante manifestou interesse e compareceu e, por este motivo, este trabalho corresponde a um Estudo de Caso. Foram coletados dados de natureza qualitativa através de um questionário semiestruturado e, após, solicitou-se que o participante esboçasse um plano de aula em acordo com o que foi discutido no decorrer da oficina. O professor participante mostrou conhecimento e propriedade acerca do tema abordado e apontou que há necessidade em atribuir melhores condições às capacitações docentes.
A Contação de história como estratégia para o ensino de ciências
Authors: Barros Hugo Noronha da Silva , Cardoso Ana Carolyne De Oliveira , Oliveira Denise Ana Augusta Dos Santos , Messeder Jorge Cardoso
Published: April 2021

O artigo traz discussões sobre uma intervenção pedagógica, proposta em um projeto do Programa Institucional de Bolsas de Iniciação Científica (PIBIC), que objetivou promover uma associação entre histórias infantojuvenis e o ensino de ciências. As atividades foram baseadas no enfoque Ciência, Tecnologia e Sociedade (CTS), a partir de um estudo do tipo qualitativo, classificado como pesquisa-intervenção. O tema norteador da pesquisa se deu a partir de uma contação de história, para 23 crianças do 4º ano do ensino fundamental da rede municipal do município de Duque de Caxias (RJ). Em seguida, foram desenvolvidas estratégias didáticas em sala de aula, promovendo a abordagem CTS, por meio das narrativas da literatura infantojuvenil, o que propiciou uma oficina de confecção de lunetas com discussões humanísticas e uma atividade que evidenciou riscos químicos de produtos saneantes domissanitários. Assim, a pesquisa possibilitou a exploração de novas perspectivas para a alfabetização científica das crianças dessa etapa da escolarização. Os resultados apontaram para as possibilidades de se aliar as histórias infantojuvenis e o ensino de ciências, promovendo discussões humanísticas e sociocientíficas, aproximando o saber científico ao mundo real.
A ABORDAGEM CTSA NOS ANOS INICIAIS DO ENSINO FUNDAMENTAL: CONTRIBUIÇÕES PARA O EXERCÍCIO DA CIDADANIA
Authors: Maestrelli Sandra Godoi , Lorenzetti Leonir
Published: April 2021

Com o objetivo de tornar o ensino de Ciências mais significativo para a vida dos alunos e contemplar aspectos amplos, como a formação cidadã e as relações entre a ciência, a tecnologia, a sociedade e o ambiente, preconiza-se uma abordagem de ensino que tem como foco o desenvolvimento das inter-relações entre esses elementos. Portanto, o intuito deste artigo é apresentar os resultados de um estudo que analisou como a abordagem CTSA, desenvolvida por meio de uma sequência didática, pode contribuir para o desenvolvimento de conhecimentos, valores, atitudes e habilidades. A sequência didática foi desenvolvida com 24 alunos de uma escola municipal em Araucária-PR, caracterizando-se como uma pesquisa de intervenção pedagógica de natureza qualitativa. Os dados apontam que a proposta de ensino permitiu aos alunos participar ativamente do processo de construção do conhecimento. Por meio das discussões, foram desenvolvidos conhecimentos, valores, atitudes e habilidades que são elementos essenciais para o exercício da cidadania.
Variables psicosociales en las transgresiones de adolescentes y el rol de psicólogas/os en la Mediación Penal Juvenil
Authors: Rodríguez Orsi Soledad M.
Published: April 2021

La psicología en el ámbito de la justicia busca, primordialmente, comprender las motivaciones de las conductas transgresoras, a la vez que estudia la manera en que las normas o leyes influyen en la sociedad. En este artículo se exploran las variables psicosociales que circundan a los adolescentes que infringen las leyes en Argentina, España y Nicaragua, con el objetivo de alcanzar una lectura más acabada de la compleja cuestión de las transgresiones en la infancia y adolescencia. Se exponen también, los mecanismos y usos de la Mediación Penal Juvenil en estos países y el rol que desempeñan las psicólogas/os que intervienen en el proceso. El estudio comparado que aquí se implementa, permite dar visibilidad a la situación actual de los menores en diferentes regiones y generar posibles enriquecimientos recíprocos.
Derechos de los pueblos indígenas en Argentina: La brecha entre el reconocimiento formal y el goce efectivo
Authors: Sánchez Gabriel C.
Published: April 2021

Este trabajo pretende abordar la situación actual de los pueblos indígenas en Argentina, partiendo del análisis de los cambios normativos que los han afectado desde la recuperación democrática, y con el objetivo de entender los impactos logrados en sus condiciones de vida. Para ello, se abordará el marco legal vigente en Argentina, se revisarán informes de organizaciones de derechos humanos que reflejan el estado en el que viven los pueblos indígenas en Argentina, y se intentará analizar por qué existe una brecha entre los derechos consagrados a favor de los pueblos indígenas y la implementación real de los mismos.
Stigma towards Eating Disorders among Attendees and Non-Attendees of Outreach Events
Authors: Kalibatseva Zornitsa , Arnold Molly S. , Connelly Kathleen E. , Marottoli Marissa L. , Tominberg Julia , Ferri Christine , Morell Nathan
Published: April 2021

Eating disorders are among the most stigmatized psychological disorders. Individuals with eating disorders are often blamed for their disorder. Stigma acts as a significant barrier to treatment. Health promotion outreach programs can successfully change knowledge, attitudes, and behaviors associated with disordered eating. The current study examined eating disorder stigma scores among attendees of Disordered Eating Awareness and Prevention week events at a public US university and compared their stigma scores to college students who did not attend the events. The study recruited 332 participants (n = 159 attendees, n = 173 non-attendees). Attendees completed a paper-and-pencil survey after each event and non-attendees participated in an online survey. The study found that participants who attended disordered eating outreach events reported lower stigma scores than those who did not attend. Furthermore, female gender and having a family member with an eating disorder was associated with lower stigma scores; however, having an eating disorder was not. The findings emphasize the importance of integrating stigma assessment in outreach programs and reducing stigma associated with eating disorders. 
Sustainability in the Construction Industry: A Critical Analysis Between Sustainable Development Indicators and Assessment Tools
Authors: Barbosa Maria Teresa , Santos White José dos , Nogueira Marina Lucena , Carvalho Aldo , Laurindo Naíra , Silva Izabela , Rosse Vicente
Published: April 2021

Nowadays, different organizations and institutions have advanced methodologies and strategies that make it possible to assess, through parameters and indicators, the sustainability of construction projects that materialize the concept of “sustainable building”. The main aim of this research is to carry out a critical analysis between the Sustainable Development Indicators (SDI), released by the IBGE/Brazil, and the most used assessment tools in Brazil, namely: LEED and AQUA. Thus, with regard to the “green buildings” certified by these tools in the Brazilian territory, data collection was carried out in those organizations considering the parameters: the level of certification and the region of Brazil. The lack of synchronization between the data from the SDI and the assessment tools was found. Finally, recommendations are presented that aim to reduce the inconsistencies found in the assessment tools.
De black box van de WETS
Authors: Dölle F.T.C. (Frederieke) , de Boer T. (Tom)
Published: April 2021

De black box van de WETS

De bijdrage bespreekt de erkenning en tenuitvoerlegging van in andere EU-lidstaten opgelegde vrijheidsbenemende sancties in Nederland. De EU-lidstaten wilden door middel van kaderbesluiten de stroperige traditionele rechtshulp efficiënter maken. Nederland heeft aan deze wens gehoor gegeven bij de totstandkoming van de WETS. De WETS kent een belangrijke rol toe aan het hof Arnhem-Leeuwarden, dat de minister adviseert over de toelaatbaarheid van de strafoverdracht. De veroordeelde is niet bij deze procedure betrokken. De auteurs concluderen dat deze procedure op gespannen voet staat met het Unierecht en aanpassing verdient.
Microfundamentos de (inter)ação da média gerência e alta administração na implementação estratégica
Authors: Vaz Samir Lótfi , Bernardes Maria Elisa Brandão , Bulgacov Sergio , Milagres Rosileia Das Mercês
Published: April 2021

Objective: We used the microfoundations lens to contribute to studies on the interaction between top and middle managers, as well as to studies on the cognitive effets of strategy implementation.Methodology: Empirical evidence result from a survey conducted with 104 middle managers of a large size telecommunications company operating in Brazil.Originality: Making use of traditional and contemporary literature and in opposition to simplified assumptions about managers’interfaces, we revealed the relevance of managerial interactions and their idiosyncratic and inimitable nature.Results: Our analyses revealed that a combination of micro adaptation practices by middle managers and their perceptions regarding top manager’s participative leadership positively influenced the way implementation is cognitively realised. Such effects are even more pronounced when the two groups of managers experience a good relationship.Theoretical contributions: The survey, in pointing to microfoundational aspects that contribute to strategy implementation, opens up possibilities for future studies based on this theoretical perspective. It also contributes to the practice, by elucidating aspects, both behavioural and cognitive, susceptible to management and to improvements in the implementation processes.
The Polish Baltic coast as a tourist area in the light of tourism indicators
Authors: Parzych Krzysztof
Published: April 2021

The Polish coast is located at a considerable distance from the main areas of leisure tourism in Europe. In recent years this area has seen a significant growth in tourist accommodation and tourist traffic. The aim of this study was to analyse the quantitative and spatial differentiation of tourist traffic in the Polish coast. The analysis is based on statistical data from the Local Data Bank (BDL) maintained by Statistics Poland (GUS) about all seaside municipalities for which there is data on tourist arrivals. The author focuses on the most commonly used indicators of tourism activity: Baretje-Defert’s index of the tourism development, Schneider’s index of tourism intensity, Charvat’s index of intensity of tourist traffic and Defert’s index of tourist traffic density (based on data for 2014, except the number of tourist beds for 2019 year). The author found significant differences in the volume of tourist traffic across Polish coastal municipalities and between the Polish coast as a whole and other coastal areas in other European countries.
The impact of Euro 2012 on the development of municipalities hosting national teams – the case of Gniewino
Authors: Karski Łukasz Robert , Jedel Joanna Danuta
Published: April 2021

The UEFA European Football Championship, held in 2012 in Poland, has brought a wide range of benefits, including the development of the recreation infrastructure and hotel facilities across the country. The championship has changed the way Poland and Poles are perceived by Europeans and has also contributed to improving the standard of living for inhabitants of many Polish towns and cities. The aim of this article is to evaluate the impact of Euro 2012 on the development of the Sports and Conference Centre in Gniewino and how it has affected the quality of life of its residents. The study is based on the analysis of literature and source documents as well as opinions collected in a survey of 450 respondents who answered a questionnaire consisting of 9 closed questions in December 2012. The findings indicate that the Sports and Conference Centre in Gniewino is currently one of the leading training centres for major football clubs from countries around the world. It can also be concluded that the organization of the Euro championship has had a positive impact on the quality of life of residents of Gniewino.