bluuebunny/crossref_metadata_2025 huggingface dataset:
Fenomena Produk dengan Merek Palsu: Perlindungan Konsumen?
Authors: Bukit Abigail Natalia , Weley Nadia Carolina , Harahap Ranty Angriyani , Disemadi Hari Sutra
Published: July 2022

Fenomena barang merek palsu yang terjadi sekarang sangatlah marak di pasaran apalagi selama masa pandemi banyak oknum nakal yang semakin melancarkan aksinya. Akibatnya banyak peredaran barang merek palsu dikalangan sekitar masyrakat. Masyarakat banyak tertarik terhadap barang tiruan karena merasa harganya terjangkau baik untuk masyarakat kelas atas, menengah, dan bawah, barang yang dijual juga banyak di pasaran tidak seperti barang asli yang hanya didapatkan di tokonya langsung, bagi mereka sebagai konsumen barang palsu tidak pernah mendapatkan kecacatan ataupun rusak dalam barang selama pembelian berlangsung. Tujuan diadakan penelitian ini adalah untuk mengetahui apa saja fenomena barang merek palsu yang telah terjadi di Batam serta bagaimanakah bentuk perlindungan konsumen terhadap pemakainya. Penelitian ini diharapkan mampu untuk para pembeli lebih berhati-hati dalam membeli suatu barang. Metode penelitian yang kami gunakan dalam penelitian ini adalah pendekatan secara kualitatif, yaitu melakukan dan mengambil data dari responden yang penulis berikan. Selanjutnya, data tersebut kami olah untuk kebutuhan penelitian penulis. Hasil penelitian kali ini adalah bahwa masyarakat kota Batam harus lebih cermat dalam membeli suatu barang karena jika membeli barang merek palsu ada hukum yang mengatur dan pastinya hak perlindungan konsumen terjaga. Tindak pidana dari pelanggaran hak merek bersifat delik aduan dimana hanya dapat ditindak jika adanya aduan dari pihak yang telah dirugikan. Dengan demikian, upaya pengurangan barang-barang palsu khususnya di kota Batam sangatlah perlu untuk dilakukan karena dapat merugikan pemilik dari merek yang asli dan melanggar hak dari si pencipta.
The Formation of International Tourism in the Pskov Region
Authors: Filimonov Anatolii
Published: July 2022

Various forms of communication and contacts between the peoples of different countries, interest in history, culture, and traditions date back to ancient times, but only after several centuries they took on an organized character, receiving the definition of "international tourism". In the Pskov Region, for a number of reasons, it began to develop only from the end of the 1950s.The first groups of Pskov residents visited the countries of "people's democracy" (Eastern Europe) for tourist purposes in 1959, in subsequent years their number steadily increased, and the geography of trips expanded. At the same time, the first tourists from foreign countries began to arrive in Pskov, which was opened to foreigners in 1959. In 1960, a branch of the VAO "Intourist" was organized to organize their reception, but due to the small influx of foreigners, it was abolished in 1963 and revived only a few years later. Pskov was the main object of international tourism, and later the Pushkin Reserve, Izborsk, and Pechory became such. The flow of foreign tourists was hindered by the insufficiently developed infrastructure, the existing inconveniences in reception and service, shortcomings in the condition and improvement of tourist facilities, etc. In addition to the VAO "Intourist", the regional Council of Trade Unions and the BMMT "Sputnik" were engaged in organizing foreign tourism, the number of foreign tourists increased from year to year.
The Image of Pius XII in Modern Cinema (on the Example of the Film «Pius XII: Under the Roman Sky»)
Authors: Mordzilovich Anna
Published: July 2022

The article is dedicated to the formation of the image of Pope Pius XII (1939–1958) in modern cinema. The author focuses on the film «Pius XII: Under the Roman Sky» («Sotto il cielo di Roma», 2010, directed by Christian Duguay), which tells about the story of the events during the German occupation of Rome in World War II. Besides, the article traces the evolution of the Pope’s image in cinema from the 1940s/1950s to the present day.
      The first films about Pius XII appeared already during his lifetime and created a positive image of the Pope. For instance, the Italian director Romolo Marchellini portrayed the pontiff as a mediator of peace between peoples and as a «living saint».
Since the 1960s a negative image of Pius XII is being formed in the cinema. The reasons are the beginning of a critical rethinking of the Nazi past and the trials of Nazi criminals, during which new details of the Holocaust were revealed. The silence of Pius XII was criticized in a number of fiction books (Rolf Hochhut, Robert Katz), which later was used as a basis of several films. Among them, the most popular is the film «Amen» (2002, directed by Costa-Gavras).
The film «Pius XII: Under the Roman Sky» (2010) is one of the first attempts to overcome the negative image of Pius XII that has developed in cinema over the past years. Unlike previous films, here the pontiff is portrayed not only as a political, but also as a spiritual leader. Since the film is based on beatification documents, the Pope appears as an active defender of the Jews. This film and the features of the Pius XII’s image are analyzed in detail in the article. 
      It is concluded that the opening of Vatican archives on the pontificate of Pius  XII may contribute to the further development of this Pope’s image in cinema.
Single-dose Acute Toxicity of 4-F-MDMB-BUTINACA Designer Cannabis Drug: LD50 and Histological Changes in Mice
Authors: Elkhatim H. Abdelgadir ElAmin  , Renad H. F. Albloi  , Abdulsallam Bakdash  , Sachil Kumar
Published: July 2022

The purpose of this research was to evaluate the single-dose toxicity of 4-F-MDMB-BUTINACA in Swiss albinomice using histopathological analysis of liver and kidney specimens.The experimental protocol included oral treatment of mice with different doses (5, 50, 300, 2000 mg/kg bodyweight of 4-F-MDMB-BUTINACA) for 24 hours. At the end of the treatment, blood samples had been drawn, andrenal and hepatic tissues have been excised from the experimental mice groups for histological examinations.The results revealed that dose-dependent treatment with 4-F-MDMB-BUTINACA causes mild tremor clinicalsigns with low doses and photophobia (sensitivity to light) and even cessation of breathing as a potential cause ofdeath with high doses in treated mice.The LD50 value of 4-F-MDMB-BUTINACA was 32.60 mg/kg, which is considered as a chemical compound of lowtoxicity. Histological studies confirmed that liver and kidney toxicities have been manifested in the findings ofcongestion, necrosis, inflammation, and bleeding within the liver and to lesser extent in the kidneys.
Solvent-induced assembly of mono- and divalent silica nanoparticles
Authors: Liu Bin , Duguet Etienne , Ravaine Serge
Published: July 2022

Particles with attractive patches are appealing candidates for use as building units in the objective of fabricating novel colloidal architectures by self-assembly. Here, we report the multi-step synthesis of one-patch silica nanoparticles with a well-controlled patch-to-particle size ratio. Their assembly can be triggered by reducing the solvent quality for the polystyrene chains which serve as a patch. Dimers or trimers can be obtained by tuning the patch-to-particle size ratio. When mixed with two-patch nanoparticles, the one-patch nanoparticles control the length of the resulting chains, by behaving as colloidal chain stoppers. The present strategy allows the future elaboration of novel colloidal structures by controlled assembly of nanoparticles.
Stochastic Analysis of Asset Price Returns for Capital Market Domain
Authors: Amadi, Innocent Uchenna , Charles Anthony
Published: July 2022

The solution of differential equations and stochastic differential equations of time-varying investment returns is considered. Precise conditions are obtained which govern asset price return rate through multiplicative and multiplicative inverse trends series. From the analysis of the proposed model showed that multiplicative inverse trend series is efficient and reliable than multiplicative trend in both deterministic and stochastic systems. Furthermore, the analytical solutions were explicitly verified graphically and discussed accordingly.
The role of private sector in global health: A Scoping Review Protocol
Authors:   Vanke School of Public Health, Tsinghua University, He Qiwei , Lu Qisai , Meng Qing , Huang Aidan , Sun Zhuanlan , Fang Yongxiang , Shi Wen , Bai Zhenggang , Tang Kun
Published: July 2022

Review question / Objective: The research question is: What role does the private sector play in global health? Our scoping review aims to: 1) provide a systematic overview of existing relevant research on private sector involved in global health activities; 2) identify the various types of roles that for-profit private sector play in global health; and 3) comprehensively summarize those roles and explore related research gaps in this research domain. Background: Private sectors play an important role in global health in most of the world's health systems. Some critical services provided by private sectors in combating the COVID-19 pandemic significantly mitigated the negative consequences. Thus, it is necessary to conduct a scoping review to investigate the role of the private sector in global health comprehensively and systemically.
Effect of supplemental parenteral nutrition on mortality in critically ill adult patients: a meta-analysis and sub-group analysis
Authors:   Beijing hospital, national center of gerontology, li peng , liu Junjun
Published: July 2022

Review question / Objective: Several observational studies demonstrated that increased nutrition deliver by supplementary parenteral nutrition (SPN) plus enteral nutrition (EN) could reduce the rate of mortality in critically ill patients. Therefore, we aimed to compare and evaluate the effect of SPN plus EN for critically ill patients. Eligibility criteria: Inclusion criteria: 1) Study types: published randomized controlled clinical studies or cohort studies; 2) Study subjects: adult patients with severe illness; 3) Intervention: The experimental group was given SPN combined with EN nutritional support treatment; 4) Control: the control group was given EN nutritional support or other nutritional support; 5) Outcome indicators: mortality, infection, length of hospital stay and ICU stay, mechanical ventilation duration.
Passive Autocatalytic Recombiners Periodic Testing Issue
Authors: Čalić Violeta
Published: July 2022

During the refueling outage (RFO) 2013 at NPP Krško, the electric hydrogen recombiners, a system for the hydrogen control during severe accidents and design basis accidents, were replaced by passive autocatalytic recombiners (PARs). During the next RFOs in 2015, 2016 and 2018, periodic tests of PAR cartridges were performed. The periodic testing of NIS-PARs shall prove that the catalytic reaction starts up as specified. According to the licenced testing procedure, each outage six cartridges were obtained and tested in the NIS PAR test device (TD). Randomly selected PAR cartridges did not pass the periodic test at room temperature (RT). Cartridges that do not pass the periodic testing have to be regenerated according to NEK procedure, followed again by a test in the TD to demonstrate the success of the regeneration. The effort of a full regeneration of all cartridges is not necessary and conservative. Due to significant unexpected workload during outages, the need for enhanced testing procedure with higher catalyst test temperature is priority. The concept for this is based on the conclusion that the PARs installed in NPP Krško were functional under accident conditions during the operational cycles (OL27, OL28 and OL29) even though PAR cartridges did not pass the periodic testing on RT (testing at higher but well below accident temperatures was successful). Revision of procedure and methodology in that direction requires development of the new TD. New TD will allow PAR cartridge measurements at defined elevated temperatures (range 40 - 70 deg C). It shall be vacuum oven type device or upgraded current NIS device. In both examples it shall provide testing of at least two cartridges at the same time, independently, however the whole cartridge shall be tested. Test gas remains 3 vol. % hydrogen in the air. For a detailed plant specific investigation of this catalytic material behavior, increased testing of cartridges was developed. Additionally, testing of different batch behavior was performed.
Use of Simplified Nuclear Power Plant Simulator
Authors: Čepin Marko
Published: July 2022

Simplified nuclear power plant simulator is a tool for simulating normal, abnormal and emergency operation of a nuclear power plant. The nuclear power plant with two loop pressurized water reactor and with inverted U-bend steam generators and dry containment system is considered. One loop with the pressurizer is modeled separately from the other loop without it. The model deals with 138 main input parameters related with the plant parameters such as pressures, temperatures, levels, power, setpoints, concentrations, capacities, masses and dimensionless numbers. The initial conditions contain 110 parameters. 18 initiating events from the set of internal initiating events can be considered. The objective of the work is to show the applicability of the simplified nuclear power plant simulator for modelling of the selected scenarios from a set of selected design basis accidents for the education purposes. Selected initiating events and scenarios have been identified and the data about them was collected. The simulation of the scenarios was performed. The initial conditions have been determined and the operational characteristics were modelled in sense to timely model plant automatic actuations and manual actions of plant operators. The results have been obtained in sense of time dependent curves of the main parameters of interest for showing the state of the plant itself and its systems and subsystems. The obtained results have been compared with the results of other simulations. The differences and the similarities have been discussed. The comparison of the results with some measurements and mostly with other simulations shows some degree of similarity and some differences, which differ among the parameters of interest. In general, the resulted comparisons show acceptability of simulator for education purposes.
PCA Benchmark Analysis with ADVANTG3.0.1. and MCNP6.1.1b Codes
Authors: Matijević Mario , Pevec Dubravko , Petrović Bojan
Published: July 2022

The Pool Critical Assembly Pressure Vessel (PCA) benchmark is a well known benchmark in the reactor shielding community which is described in the Shielding Integral Benchmark Archive and Database (SINBAD). It is based on the experiments performed at the PCA facility in the Oak Ridge National Laboratory (ORNL) and it can be used for the qualification of the pressure vessel fluence calculational methodology. The measured quantities to be compared against the calculated values are the equivalent fission fluxes at several experimental access tubes (A1 to A8) in front, behind, and inside the pressure-vessel wall simulator. This benchmark is particularly suitable to test the capabilities of the shielding calculational methodology and cross-section libraries to predict invessel flux gradients because only a few approximations are necessary in the overall analysis. This benchmark was analyzed using a modern hybrid stochastic-deterministic shielding methodology with ADVANTG3.0.1 and MCNP6.1.1b codes. ADVANTG3.0.1 is an automated tool for generating variance reduction (VR) parameters for Monte Carlo (MC) calculations with MCNP5v1.60 code (and higher versions). It is based on the multigroup, discrete ordinates solver Denovo, used for approximating the forward-adjoint transport fluxes to construct VR parameters for the final MC simulation. The VR parameters in form of the weight windows and the source biasing cards can be directly used with unmodified MCNP input. The underlining CADIS methodology in Denovo code was initially developed for biasing local MC results, such as point detector or a limited region detector. The FW-CADIS extension was developed for biasing MC results globally over a mesh tallies or multiple point/region detectors. Both CADIS and FW-CADIS are based on the concept of the neutron importance function, which is a solution of the adjoint Boltzmann transport equation. The equivalent fission fluxes calculated with MCNP are based on several highenergy threshold reactions from international dosimetry libraries IRDF-2002 and IRDFF-2014, distributed by the IAEA Nuclear Data Section. The obtained results show a good agreement with referenced PCA measurements. Visualization of the deterministic solution in 3D was done using the VisIt code from the Lawrence Livermore National Laboratory (LLNL).
What-If Analysis: Antecedents and Consequences Factors of Counterfactual Thinking
Authors:   Amity University, Noida, Dembla Hena , Mathur Anurakti ,   Amity University, Noida, Tiwari Priyanka ,   Head of the Department Manav Rachna, University
Published: July 2022

The present study shows the relationship between counterfactual thinking and resilience, optimism, sense of coherence, hardiness, benign and malicious envy, rational and intuitive decision making, rumination. The sample for the study was 200 young adults (18-35 years). The assessment scales used for the present study were The Brief Resilience Scale (BRS), Sense of Coherence Scale(SoC), A Short Hardiness scale, The Benign and Malicious envy scale(BeMaS), Rumination Revised Scale(RSS), Decision Making Questionnaire(DMQ), Counterfactual Thought for Negative Events Scale (CTNES) and Life-Orientation Revised Scale(LOT-R).Correlation and regression analysis was done using SPSS(20.0) software. The findings of the study showed a significant inverse correlation between counterfactual thinking and optimism whereas a significant direct correlation was observed between counterfactual thinking and resilience, sense of coherence, hardiness, benign and malicious envy, rational and intuitive decision making and rumination. It was also found that rational and intuitive decision making and rumination were the best predictor of counterfactual thoughts respectively. Keyword: Counterfactual Thinking, Resilience, Optimism, Sense Of Coherence, Hardiness, Benign And Malicious Envy, Rational And Intuitive Decision Making and Rumination
Green Hydrogen in India
Authors:   Assistant Professor, University of Petroleum and Energy Studies, Ghosal Avishek , Kumar Anil ,   Professor, University of Petroleum and Energy Studies
Published: July 2022

India is one among the largest energy consumers worldwide. Fuels contribute majorly to meet these energy demands leading to various environmental problems. Hence, this article discusses the different processes of water electrolysis as an alternate approach to produce highly pure hydrogen in an eco-friendly manner without any carbon emissions. Current status related to manufacturing, storage and transportation of hydrogen have also been discussed. Challenges faced regarding green hydrogen in India, such as cost, conveyance, storage, policies and public acceptance have been highlighted along with some of the action plans for hydrogen production in India with their estimated cost and completion time. Keywords: Green hydrogen, renewable, India, clean Hydrogen, water electrolysis
Cystic fibrosis-related diabetes
Authors:   3rd Clinic of Pediatrics, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Anton-Paduraru Dana-Teodora , Oltean Carmen ,   Children’s Emergency Hospital ”Sf. Maria”, Iasi, Romania, Iliescu Maria-Liliana ,   Department of Public Healthcare and Medical Management, Romania, Baciu Ginel ,   Faculty of Medicine – 1st Clinic of Pediatrics,”Dunarea de Jos” University, Galati, Romania, Trandafir Laura Mihaela ,   3rd Clinic of Pediatrics, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Published: July 2022

Cystic fibrosis-related diabetes is an entity distinct from diabetes mellitus type 1 and 2, but with symptoms characteristic to them. Along with the extension of the life expectancy, the prevalence of diabetes increased in association with a more severe decline of the lung function and a poorer nutritional status in comparison to that of people with cystic fibrosis but without diabetes. The authors present current data regarding the prevalence and physiopathology of the disease, the clinical picture, and the useful examinations in establishing the diagnosis, the therapeutic possibilities and disease prognostic. We conclude that the early diagnosis and appropriate therapeutic interventions may diminish the negative impact of diabetes on the lung function and the nutritional status in cystic fibrosis.
Etiopatogenia multifactorială a purpurei Henöch-Schönlein la vârsta pediatrică
Authors:   Clinica IV Pediatrie, Spitalul Clinic de Urgenţă pentru Copii „Sf. Maria“, Iaşi, România, Mocanu Adriana ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Miron Ingrith ,   Clinica IV Pediatrie, Spitalul Clinic de Urgenţă pentru Copii „Sf. Maria“, Iaşi, România,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Diaconescu Smaranda ,   Clinica V Pediatrie, Spitalul Clinic de Urgenţă pentru Copii „Sf. Maria“, Iaşi, România,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Gimiga Nicoleta ,   Clinica V Pediatrie, Spitalul Clinic de Urgenţă pentru Copii „Sf. Maria“, Iaşi, România, Olaru Claudia ,   Clinica V Pediatrie, Spitalul Clinic de Urgenţă pentru Copii „Sf. Maria“, Iaşi, România,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Burlea Marin ,   Clinica V Pediatrie, Spitalul Clinic de Urgenţă pentru Copii „Sf. Maria“, Iaşi, România,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România
Published: July 2022

Purpura Henöch-Schönlein (PHS) este o afecţiune a vaselor mici caracterizată printr-un răspuns anormal al sistemului imun: imunoglobulina A (IgA), fracţiunea a 3-a a complementului şi depunerea de complexe imune circulante în pereţii arteriolelor, venulelor şi a capilarelor. Sunt afectaţi predominant copiii, dar simptomatologia poate apărea şi la vârsta adultă. Boala este mai frecventă la pacienţii de sex masculin. Etiologia purpurei nu este deocamdată cunoscută, însă se pare ca există anumiţi factori de risc pentru apariţia acesteia: agenţi infecţioşi (Streptococ, parvovirusuri), înţepături de insecte, alimente sau medicamente (antibiotice, antihistaminice). Susceptibilitatea la PHS poate avea origine genetică. Numeroase rapoarte sugerează că deficienţa complementului (C4) datorată deleţiei genelor ce codează sinteza acestei fracţiuni determină predispoziţia la nefropatie IgA şi la nefrita Henöch-Schönlein.
Posibilităţi şi limite de terapie într-un caz de hipocondroplazie la copil
Authors:   Clinica II Pediatrie, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Alexoae Monica , Rugină Aurica ,   Clinica II Pediatrie, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Moraru Evelina ,   Clinica II Pediatrie, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Ioniuc Ileana ,   Clinica II Pediatrie, Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România
Published: July 2022

Hipocondroplazia este o afecţiune genetică autozomal dominantă determinată de mutaţii ale genei receptorului 3 al factorului de creştere fibroblastică. Hipostatura dizarmonică are un impact negativ asupra calităţii vieţii, care poate fi ameliorat prin diagnostic precoce şi instituirea tratamentului cu hormon de creştere recombinant. Autorii prezintă cazul unei adolescente la care diagnosticul s-a precizat tardiv, motiv pentru care a pierdut şansa acestei terapii.
Sindromul Leopard. Cazuri familiale
Authors:   Spitalul Clinic de Pediatrie, Sibiu, România, Iurian Sorin Ioan , Brunner Han ,   Departamentul de Genetică, Universitatea Radboud, Olanda, Yntema Helger ,   Departamentul de Genetică, Universitatea Radboud, Olanda, Mehedinţu Bogdan ,   Unitatea Primiri Urgenţe, Spitalul Clinic de Pediatrie, Sibiu, România
Published: July 2022

Sindromul LEOPARD este o afecţiune ce include multiple anomalii dismorfogenetice. Sindromul LEOPARD, ca şi sindromul Noonan, este determinat de mutaţii ale genei PTPN11. Autorii menţionează particularităţile diagnostice la 2 cazuri înrudite cu dismorfism facial. Cazul index este reprezentat de băiat de 10 ani evaluat pentru dismorfism cranio-facial asociat cu retard mental. Antecedente heredo-colaterale: fără consangvinitate; tatăl pacientului şi soră cu dismorfism facial. Examenul clinic: retard staturo-ponderal, pistrui axilari, pete café-au-lait diseminate, dismorfism facial, pterigium coli, anomalii scheletice, retard mental. Investigaţiile sangvine şi eco-cardiografia: fără modificări. Pentru diagnosticul diferenţial s-au considerat sindroamele Noonan, Greig, neurofibromatoza tip 1, sindromul Mc Cune-Albright. Evaluarea genetică: cariotip normal; secvenţierea genei PTPN11 a relevat mutaţia ce confirmă sindromul LEOPARD. Analiza genetică a relevat aceeaşi mutaţie la tatăl pacientului. Concluzii. Autorii au descris 2 cazuri familiale cu craniu dismorf, anomalii scheletice, pigmentaţia pielii, dizabilităţi mentale şi statură mică, justificând evaluarea genetică care a identificat o afecţiune genetică foarte rară.
Multifactorial etiopathogeny of Henöch-Schönlein purpura in pediatric age
Authors:   IVth Pediatrics Clinic, „Sf. Maria“ Pediatric Hospital, Iasi, Romania, Mocanu Adriana ,   “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Miron Ingrith ,   IVth Pediatrics Clinic, „Sf. Maria“ Pediatric Hospital, Iasi, Romania,   “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Diaconescu Smaranda ,   Vth Pediatrics Clinic, „Sf. Maria“ Pediatric Hospital, Iasi, Romania,   “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Gimiga Nicoleta ,   Vth Pediatrics Clinic, „Sf. Maria“ Pediatric Hospital, Iasi, Romania,   “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Olaru Claudia ,   Vth Pediatrics Clinic, „Sf. Maria“ Pediatric Hospital, Iasi, Romania,   “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Burlea Marin ,   Vth Pediatrics Clinic, „Sf. Maria“ Pediatric Hospital, Iasi, Romania,   “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Published: July 2022

Henöch-Schönlein purpura is a small-vessel vasculitis characterized by an abnormal response of the immune system: immunoglobulin A (IgA), C3 and immune complex deposition in arterioles, capillaries and venules. The syndrome is mostly seen in children, but it may affect people of any age. It is more common in boys than in girls. The etiology of Henöch-Schönlein purpura is unknown. Multiple infectious agents as well as drugs, foods, and insect bites may trigger Henöch-Schönlein purpura. Susceptibility to HSP may have a genetic origin. Several reports suggest that deficiency of complement 4 (C4) from deletion of C4 genes predisposes patients to IgA nephropathy and HSP nephritis.
Evaluating insulin resistance in children: a critical appraisal of minimal models
Authors:   Department of Genetics, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania, Pienar Corina , Stroescu Ramona ,   1st Pediatrics Clinic, “Louis Turcanu” Emergency Hospital for Children, Timisoara, Romania, Chirita-Emandi Adela ,   Department of Genetics, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania, Dobrescu Andreea ,   Department of Genetics, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania,   1st Pediatrics Clinic, “Louis Turcanu” Emergency Hospital for Children, Timisoara, Romania, Puiu Maria ,   Department of Genetics, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania,   3rd Pediatrics Clinic, “Louis Turcanu” Emergency Hospital for Children, Timisoara, Romania
Published: July 2022

Childhood obesity has followed, during the last two decades, an ascending trend. Insulin resistance (IR) is central to the pathophysiology of obesity. So far, several methods of assessing IR have been proposed. We aimed to evaluate critically some of the simplest methods used to assess IR in the pediatric population. We studied retrospectively the records of children evaluated for obesity in the “Louis Ţurcanu” Emergency Hospital for Children Timisoara, over a period of 10 years. The study population consisted of 342 children. Anthropometric and metabolic variables were analyzed, and the following indices of IR were assessed: impaired glucose tolerance (IGT), Homeostatic Model of Assessment-IR (HOMA-IR), Homeostatic Model of Assessment- b (HOMAβ), Quantitative Insulin Sensitivity Check Index (QUICKI) as well as the TG/HDLc ratio. Data was expressed as frequencies, means ± standard deviations or median ± interquartile interval for or a 95% confidence interval. The t-test for independent groups or the Mann-Whitney test to assess differences of IR indices across weight, gender and pubertal categories. HOMA-IR diagnosed the most children with IR, at the opposite pole we found QUICKI. IGT was a rare finding. It is necessary to reconsider how we assess the carbohydrate metabolism in children. Of the methods we evaluated, HOMA-IR is the optimal method for assessing IR children.
Long-Term Outcomes of Congenital Adrenal Hyperplasia
Authors: Nordenström Anna , Lajic Svetlana , Falhammar Henrik
Published: July 2022

A plethora of negative long-term outcomes have been associated with congenital adrenal hyperplasia (CAH). The causes are multiple and involve supra-physiological gluco- and mineralocorticoid replacement, excess adrenal androgens both intrauterine and postnatal, elevated steroid precursor and adrenocorticotropic hormone levels, living with a congenital condition as well as the proximity of the cytochrome P450 family 21 subfamily A member 2 (CYP21A2) gene to other genes. This review aims to discuss the different long-term outcomes of CAH.
Osseointegrated Implants and Osseoperception - A Review
Authors:   Department of Prosthodontics, Maulana Azad Institute of Dental Sciences, India, Deepika Kumari , Bhatnagar Atul , Gupta Rekha
Published: July 2022

There are many studies suggest that a peripheral feedback pathway can be restored with osseointegrated implants even after tooth loss. This implant mediated sensory-motor control, known as osseoperception may have important clinical implications in improving masticatory function with implant supported prosthesis. To understand this psychophysical integration of implants, available literature was evaluated using various online resources such as Pubmed, Google scholar, etc. using keywords like “osseoperception”, tactile sensibility, implant mediated sensory-motor control and mechanoreceptors. The long-term integration of an implant-bone restoration depends in part on optimal load distribution on the bearing tissue. Because natural teeth and implants vary in their anchorage mechanisms so there is a fundamental difference in the perception and control of the loading. The current review of literature deals with these issues and has been summarized under following heads: • Mechanism of osseoperception • Neurophysiological and psychophysical methods of assessing phenomenon of osseoperception • Mechanoreceptors contributing to osseoperception • Different concepts of osseoperception Keywords: ­ Osseointegration, osseoperception, active threshold, passive threshold, dental implant
Ethnobotanical Study of Indigenous Plants used by the Members of Mantheding Community in Limpopo Province, South Africa
Authors: Rankoana Sejabaledi Agnes
Published: July 2022

This study is an ethnobotanical survey conducted in the Limpopo Province (South Africa) with the goal of collecting detailed information about the cultural significance of indigenous plants in human culture. Three hundred and forty semi-structured interviews with traditional health practitioners and community members knowledgeable about plant use yielded ethnobotanical data on a variety of indigenous plant uses. The ethnobotanical data collected produced 77 species belonging to 31 families. The diversity of plants produced 45 sources of medicine, 17 sources of stock feed, 13 sources of technological materials, 10 food sources, and six fuel sources. It was found that most plants (15.5%) have dual uses as sources of food and fodder, as well as sources of fruits that are also used for medicinal purposes and timber for the manufacturing of household utensils. The study findings demonstrated how traditional knowledge about indigenous plants may be leveraged to address some of society’s most pressing issues, including food insecurity, poor health and wellbeing, poverty, and unemployment. The study reported that the rural community’s continued dependence on indigenous plant materials for subsistence is an example of cultural resilience in the pursuit of sustainable development. The research is crucial because it provides information on the plants that remain prominent in Mantheding culture and their many uses in the community’s culture.

Keywords: Ethnobotany; indigenous plants; sustainable development; Limpopo Province
TECHNO-ECONOMIC COMPARISON OF BIFACIAL VS MONOFACIAL SOLAR PANELS
Authors: Kumbaroğlu Gürkan S. , Çamlibel Mehmet Emre , Avcı Cem
Published: July 2022

A techno-economic analysis is performed for a solar farm with a 35 MWe installed capacity using bifacial solar panels and compared with standard monofacial solar panels at the same installed capacity level. The bifacial panel usage gain from total panel efficiency is identified from 4-year measurements to be within a range of 7.9–16.8% depending on monthly yield. A Monte Carlo simulation is carried out to forecast electricity prices under uncertainty. In terms of Net Present Value, it is found that the bifacial farm yields 12.6% higher values than the monofacial options under reference assumptions. An incremental internal rate of return (IRR) analysis is carried out yielding an IRR for the bifacial panels of 44% under various scenarios. The sensitivity analysis reveals that results are highly sensitive to discount rate and lifetime, and less sensitive to electricity prices. SWOT analysis performed to compare the bifacial with the monofacial panel and evaluate panels according to internal and external factors. The study was concluded with a summary of the technical specifications based on the test results. The results were used to identify that 12.2% added net present value corresponding to $186.7 – $214.5 per unit MW (under various electricity price trajectories) can be used as a reference for assessing the benefit for usage of bifacial PV for 35 MW type medium-size projects. In summary, it is suggested that bifacial solar PV with its outstanding techno-economic results can be the driving force of the growing solar PV market.
The Circumgalactic Medium from the CAMELS Simulations: Forecasting Constraints on Feedback Processes from Future Sunyaev–Zeldovich Observations
Authors: Moser Emily , Battaglia Nicholas , Nagai Daisuke , Lau Erwin , Machado Poletti Valle Luis Fernando , Villaescusa-Navarro Francisco , Amodeo Stefania , Anglés-Alcázar Daniel , Bryan Greg L. , Dave Romeel , Hernquist Lars , Vogelsberger Mark
Published: July 2022

It is important to understand the cycle of baryons through the circumgalactic medium (CGM) in the context of galaxy formation and evolution. In this study, we forecast constraints on the feedback processes heating the CGM with current and future Sunyaev–Zeldovich (SZ) observations. To constrain these processes, we use a suite of cosmological simulations, the Cosmology and Astrophysics with MachinE Learning Simulations (CAMELS). CAMELS varies four different feedback parameters of two previously existing hydrodynamical simulations, IllustrisTNG and SIMBA. We capture the dependences of SZ radial profiles on these feedback parameters with an emulator, calculate their derivatives, and forecast future constraints on these feedback parameters from upcoming experiments. We find that for a galaxy sample similar to what would be obtained with the Dark Energy Spectroscopic Instrument at the Simons Observatory, all four feedback parameters can be constrained (some within the 10% level), indicating that future observations will be able to further restrict the parameter space for these subgrid models. Given the modeled galaxy sample and forecasted errors in this work, we find that the inner SZ profiles contribute more to the constraining power than the outer profiles. Finally, we find that, despite the wide range of parameter variation in active galactic feedback in the CAMELS simulation suite, we cannot reproduce the thermal SZ signal of galaxies selected by the Baryon Oscillation Spectroscopic Survey as measured by the Atacama Cosmology Telescope.
Constraining the Milky Way Halo Kinematics via Its Linear Response to the Large Magellanic Cloud
Authors: Rozier Simon , Famaey Benoit , Siebert Arnaud , Monari Giacomo , Pichon Christophe , Ibata Rodrigo
Published: July 2022

We model the response of spherical, nonrotating Milky Way (MW) dark matter and stellar halos to the Large Magellanic Cloud using the matrix method of linear response theory. Our computations reproduce the main features of the dark halo response from simulations. We show that these features can be well separated by a harmonic decomposition: the large-scale over/underdensity in the halo (associated with its reflex motion) corresponds to the ℓ = 1 terms, and the local overdensity to the ℓ ≥ 2 multipoles. Moreover, the dark halo response is largely dominated by the first-order forcing term, with little influence from self-gravity. This makes it difficult to constrain the underlying velocity distribution of the dark halo using the observed response of the stellar halo, but it allows us to investigate the response of stellar halo models with various velocity anisotropies: a tangential (respectively radial) halo produces a shallower (respectively stronger) response. We also show that only the local wake is responsible for these variations, the reflex motion being solely dependent on the MW potential. Therefore, we identify the structure (orientation and winding) of the in-plane quadrupolar (m = 2) response as a potentially good probe of the stellar halo anisotropy. Finally, our method allows us to tentatively relate the wake strength and shape to resonant effects: the strong radial response could be associated with the inner Lindblad resonance, and the weak tangential one with corotation.
The Disk Wind in GRS 1915+105 as Seen by Insight–Hard X-Ray Modulation Telescope
Authors: Liu Honghui , Fu Yuhan , Bambi Cosimo , Jiang Jiachen , Parker Michael L. , Ji Long , Kong Lingda , Zhang Liang , Zhang Shu , Zhang Yuexin
Published: July 2022

We analyze three observations of GRS 1915+105 in 2017 by Insight–Hard X-ray Modulation Telescope when the source was in a spectrally soft state. We find strong absorption lines from highly ionized iron, which are due to absorption by disk wind outflowing at a velocity of ∼1000 km s−1 along our line of sight. Two of the three observations show large amplitude oscillation in their light curves and the variation pattern corresponds to state κ of GRS 1915+105. From time-averaged and flux-resolved analysis, we find that the variation in the ionization state of the disk wind follows the X-ray continuum on timescales from hundreds of seconds to months. The radial location of the disk wind is consistent with thermal driving. The mass-loss rate due to the outflowing wind is comparable to the mass accretion rate in the inner disk, which demonstrates the important role of the disk wind in the disk accretion system.
Factors Affecting the Performance of Public Health Efforts Program Officers at Community Health Centers
Authors: Nusi Supriadi A. , Pallutturi Sukri , Razak Amran , Darmawansyah Darmawansyah , Mallongi Anwar , Saleh Lalu Muhammad
Published: July 2022

BACKGROUND: Changes in the duties and functions of public health centers by the national health insurance policy have an impact on the declining performance of public health efforts. The 2015 performance evaluation showed that the MDGs targets were not in line with expectations, especially the increase in the maternal mortality rate, and other indicators.

AIM: This study aims to determine the factors that affect the performance of public health efforts program officers in Tolitoli Regency, consisting of health promotion, maternal and child health, environmental health, nutrition, tuberculosis, and HIV/AIDS.

METHODS: This research was conducted throughout the Public Health Center in Tolitoli Regency. This research design was quantitative with survey methods. Data were analyzed using Chi-square. The sample in this study was a total of 84 respondents, with each health center having six respondents.

RESULTS: The results of the analysis showed that factors outside the organization and job autonomy were not significantly affecting the performance of public health efforts officers with a p-value sequentially as 0.195 and 0.130, and proactive officers significantly affected performance with a p = 0.017.
Long-Term Contraceptive Method Use among Married Women of Reproductive Age: Cross Sectional Study in South Sumatra
Authors: Idris Haerawati , Sari Indah Purnama , Heru Heru
Published: July 2022

BACKGROUND: The population of growth rate in Indonesia is still high, including South Sumatra. The use of modern contraceptives tends to stagnate at the moment.

AIM: This study aims to analyze the determinant of long-term contraceptive method use among married women of reproductive age in South Sumatra.

METHODS: This study is a quantitative study with a cross-sectional design. We used secondary data, Indonesia Health and Demographics Survey 2017. The unit of analysis in this study is reproductive age women (15–49 years) in South Sumatra who successfully became respondents to the 2017 IDHS and married status. The number of respondents was 686. We analyzed the predictor of long-term contraceptive method use using logistic regression.

RESULTS: The proportion of users of long-term contraceptive method was 18.2%. Factors related to the use of these contraceptives include received visits from health workers, number of living children, and mother’s employment (p < 0.05). Respondent who received visits from health workers within the last 6 months was 2.7 times more likely to use long-term contraceptive method than respondent who did not receive a health worker visit.

CONCLUSION: Married women who get visits by health workers are more likely to use long-term contraceptive methods. This study result could be used as a reference for making policies that focus on increasing visit by health workers to married women and give counseling the benefit of long-term contraceptive method use.
Commercial Hormone Replacement Therapy Jeopardized Proinflammatory Factors in Experimental Rat Models
Authors: Ali Mohammed , Mahmood Isam H.
Published: July 2022

BACKGROUND: Hormonal contraceptive therapy is considered the easiest and most convenient contraceptive method. Commercially, available contraceptive combination differs in their composition and concentration of combined constituents. These variations make some of these products preferred over others by consumers based on their side effects profile.

AIM: The objective of the current research was to ascertain the proinflammatory influences of commercially available products.

METHODS: To do so, five groups of rats (ten rats in each group) were exposed to Microgynon, Depo-Provera, marvel on, and Yasmin compared to the control non-treated group. We measured proinflammatory markers including d-dimer, TNF-α (tumor necrosis factor-alpha), IL (interleukin)-6, IL (interleukin)-1B, and c-reactive protein.

RESULTS: The results confirmed that Yasmin has induced the most deleterious effects on proinflammatory markers indicated by significant elevation of IL1B.

CONCLUSION: Hormone replacement therapy should be critically indicated and precautions raised inpatient with subclinical diseases, especially cardiovascular ones.
Co-opting Separatists: Social Welfare for Cross-Border Minorities in Xinjiang
Authors: Hlásny Vladimír
Published: July 2022

Le Xinjiang est toujours le centre de conflits interethniques, religieux et politiques, créant ainsi des défis pour le gouvernement de Pékin. Notre étude, qui utilise des données historiques uniques de 1995 à 2003 sur les dépenses sociales des gouvernements des comtés au Xinjiang, établit un lien entre la composition démographique régionale et les dépenses. Les régressions par méthode de panel montrent que les comtés proches des frontières, où se trouvent des minorités ethniques et religieuses transfrontalières, dépensent plus pour l’aide sociale en raison de menace de trouble et de séparatismes des minorités. En outre, l’invasion américaine de l’Afghanistan de 2001 a entraîné une augmentation des dépenses dans les régions à minorité musulmane. Ces résultats mettent en lumière la gouvernance budgétaire dans l’ouest de la Chine et la cooptation des minorités au milieu des préoccupations des dirigeants quant aux défis pour stabiliser le régime.
A review of emerging design concepts in applied microgrid technology
Authors: Olulope Paul K. , Odetoye Oyinlolu A. , Olanrewaju Matthew O.
Published: July 2022

Most of the research in distributed generation focuses on power flow optimization and control algorithm development and related fields. However, microgrids are evolving on multiple levels with respect to the chemical processes used to manufacture the underlying technologies, deployment strategies, physical architecture (which is important to the economic factor) as well as environmental impact mitigation of microgrids. Special use cases and paradigms of deploying Distributed Generation (DG) in harmony with agricultural or decorative purposes for existing spaces are emerging, propelled by research in frontiers that the DG engineer would benefit from being aware of. Also, offshore photovoltaic (PV) has emerged as an increasingly important research area. Many nascent technologies and concepts have not been techno-economically analyzed to determine and optimize their benefits. These provide ample research opportunities from a big-picture perspective regarding microgrid development. This also provides the avenue for research in distributed generation from a physical integration and space use perspective. This study reviews a selection of developments in microgrid technology with the themes of manufacturing technology, optimal deployment techniques in physical spaces, and impact mitigation approaches to the deployment of renewable energy from a qualitative perspective.
Dynamic analysis for a class of hydrological model with time delay under fire disturbance
Authors: Su Rina
Published: July 2022

In this work, we consider the dynamic properties of a class of hydrological model with time delay under fire disturbance. The stability of the equilibrium for the model, and the existence of the Hopf bifurcation are analyzed. Moreover, the direction of the Hopf bifurcation, and the stability of these periodic solutions bifurcating are derived based on the normal form and the center manifold theory. Then, the sensitivities of fire intensity and fire frequency to soil water, trees, and grasses are analyzed by the Runge-Kutta method. The result is that, fire frequency has a more significant effect on the hydrological and ecological cycle compared with fire intensity. Finally, we analyze the effect of time delay on the hydrological model through numerical simulations.