bluuebunny/crossref_metadata_2025 huggingface dataset:
Total hip arthroplasty in patients with severe hip dysplasia and congenital pubic diastasis: report of two cases
Authors: Goetze Christian , Migliorini Filippo , Peterlein Christian Dominik
Published: September 2021

Background

Congenital bladder exstrophy is a rare malformation which is often associated with pubic diastasis and hip dysplasia. We reported the case two patients who underwent total hip arthroplasty (THA) due to advanced osteoarthritis combined with large congenital pubic diastasis (> 10 cm).

Case presentation

The first patient, a 39 years old woman with a pubic diastase and severe hip dysplasia on both sides was treated with a primary two-staged bilateral THA. Both hips were treated with a cementless osteoconductive cup (TM, Zimmer-Biomet) and a cementless stem (Alloclassic SL, Zimmer-Biomet). A 10° elevated rim liner of the cup was used in order to avoid dislocation. The main problem was represented by the fixation of the cup, given the retroverted acetabulum along with the elevated rotation centre due to the dysplastic hips. In the case two, a 52 years woman presented dysplastic osteoarthritis of the left hip. A conventional hemispherical cup (Alloclassic-Allofit, Zimmer-Biomet) was placed in the retroverted acetabulum combined with a cementless stem (Fitmore A, Zimmer-Biomet) attached at the metaphyseal proximal femur bone.

Conclusion

Our results suggest that THA may be a good strategy to manage advanced hip osteoarthritis in patients with dysplasia and congenital pubic diastasis.

Level of evidence

IV, case series.
Application of first-order feature analysis of DWI-ADC in rare malignant mesenchymal tumours of the maxillofacial region
Authors: Yu Baoting , Huang Chencui , Liu Shuo , Li Tong , Guan Yuyao , Zheng Xuewei , Ding Jun
Published: September 2021

Background

To research the first-order features of apparent diffusion coefficient (ADC) values on diffusion-weighted magnetic resonance imaging (DWI) in maxillofacial malignant mesenchymal tumours.

Methods

The clinical data of 12 patients with rare malignant mesenchymal tumours of the maxillofacial region (6 cases of sarcoma and 6 cases of lymphoma) treated in the hospital from May 2018 to June 2020 and were confirmed by postoperative pathology were retrospectively analyzed. The patients were all examined by 1.5T magnetic resonance imaging. PyRadiomics were used to extract radiomics imaging first-order features. Group differences in quantitative variables were examined using independent-samples t-tests.

Results

The voxels number of ADCmean and ADCmedian of sarcoma tissues were 44.9124 and 44.2064, respectively, significantly higher than those in lymphoma tissues (ADCmean (− 68.8379) and ADCmedian (− 74.0045)), the difference considered statistically significant, so do the ADCkurt and ADCskew.

Conclusions

The statistical difference of ADCmean and ADCmedian is significant, it is consistent with the outcome of the manual measurement of the ADC mean value of the most significant cross-section of twelve cases of lymphoma. Development of tumour volume based on the ADC parameter map of DWI demonstrates that the first-order ADC radiomics features analysis can provide new imaging markers for the differentiation of maxillofacial sarcoma and lymphoma. Therefore, first-order ADC features of ADCkurt combined ADCskew may improve the diagnosis level.
Oral health and emotional well-being in premenopausal and postmenopausal women: a cross-sectional cohort study
Authors: Yakar Nil , Türedi Asena , Emingil Gülnur , Şahin Çağdaş , Köse Timur , Silbereisen Angelika , Bostanci Nagihan
Published: September 2021

Background

Menopause, the absence of ovarian sex steroids, is frequently accompanied by emotional and physiological changes in a woman´s body, as well as oral health changes. The present study aimed to evaluate the association between the periodontal health status and emotional and physical well-being among postmenopausal women (PMW) in comparison with regularly menstruating premenopausal women (RMPW).

Methods

A total of 115 women (PMW, n = 56, mean age ± SD: 54 ± 5; RMPW, n = 59, mean age ± SD: 41 ± 4) received a comprehensive medical assessment and a full-mouth oral examination. All completed the Women’s Health Questionnaire (WHQ) to measure emotional and physical well-being. The corresponding bone mineral density (BMD) scores were obtained from participants´ medical records.

Results

Tooth loss was significantly higher in PMW than RMPW after adjusting for age (3.88 ± 2.41 vs 2.14 ± 2.43,p < 0.05). No significant difference was found in the prevalence of periodontitis between the two groups (PMW: 39.2%, RMPW: 32.2%,p > 0.05). The prevalence of periodontitis was associated with fewer daily brushing sessions in PMW (p = 0.021). Based on the WHQ, both PMW and RMPW with periodontitis had higher ‘’depressed mood’’ scores compared to periodontally healthy women (p = 0.06 andp = 0.038, respectively). The women who reported fewer daily toothbrushing sessions found to have higher depressive mood scores (p = 0.043).

Conclusions

Presence of periodontitis is associated with the emotional and physical well-being of women and reinforcement of oral healtcare is recommended at different stages of a woman’s life including menopause to reduce the risk for early tooth loss in women.
In vitro antioxidant activity of crude extracts of Harpagophytum zeyheri and their anti-inflammatory and cytotoxicity activity compared with diclofenac
Authors: Ncube Sibonokuhle F. , McGaw Lyndy J. , Njoya Emmanuel Mfotie , Ndagurwa Hilton G. T. , Mundy Peter J. , Sibanda Samson
Published: September 2021

Background

This study evaluated the in vitro antioxidant activity and comparison of anti-inflammatory and cytotoxic activity of Harpagopytum zeyheri with diclofenac.

Methods

In vitro assays were conducted using water, ethanol, and ethyl acetate extracts of H.zeyheri. The antioxidant activity was evaluated using the 2,2′-diphenyl-1-picrylhydrazy (DPPH) and 2,2′- azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays. The anti-inflammatory activity was determined by measuring the inhibition of nitric oxide (NO) on lipopolysaccharide (LPS)-induced RAW 264.7 mouse macrophages as well as cytokine (TNF-α and IL-10) expression on LPS-induced U937 human macrophages. For cytotoxicity, cell viability was determined using the 3-(4, 5-dimethylthiazol- 2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.

Results

The ethyl acetate extract had the lowest IC50 values in the DPPH (5.91 μg/ml) and ABTS (20.5 μg/ml) assay compared to other extracts. Furthermore, the ethyl acetate extracts effectively inhibited NO and TNF-α and proved to be comparable to diclofenac at some concentrations. All extracts of H. zeyheri displayed dose-dependent activity and were associated with low levels of human-IL-10 expression compared to quercetin. Furthermore, all extracts displayed low toxicity relative to diclofenac.

Conclusions

These findings show that H. zeyheri has significant antioxidant activity. Additionally, similarities exist in the inflammatory activity of H. zeyheri to diclofenac at some concentrations as well as low toxicity in comparison to diclofenac.
Case report laparoscopy-assisted pre-pubic urethrostomy as a palliative procedure for resection of distal urethral tumor in a female dog
Authors: Prządka Przemysław , Liszka Bartłomiej , Lachowska Sonia , Dzimira Stanisław , Ciaputa Rafał , Tunikowska Joanna , Juźwiak Łukasz , Kucharski Paweł , Rudno-Rudzińska Julia , Kiełbowicz Zdzisław
Published: September 2021

Background

This paper presents the first described case of laparoscopy-assisted prepubic urethrostomy and laparoscopic resection of a tumor of the distal part of the urethra in a female dog as a palliative treatment.

Case presentation

An intact, 11 -year-old, mixed breed female dog, weighing 15 kg, was admitted with signs of urinary obstruction and difficulty with catheterization. Vaginal, rectal, and endoscopic examinations revealed a firm mass in the pelvic cavity at the level of the pelvic urethra. Ultrasound and computed tomography examination showed enlargement of the urethral wall (5.5 cm width and 3 cm thick), which was significantly restricting the patency of the urethra. The lesion affected only the distal part of the urethra without the presence of local or distant metastatic changes.

The affected portion of the urethra was laparoscopically removed while performing pre-pubic urethrostomy with laparoscopy. The patient regained full consciousness immediately after the end of anesthesia, without signs of urinary incontinence. Histopathological examination of the removed urethra revealed an oncological margin only from the side of the bladder. In the period of 2.5 months after the procedure, the owner did not notice any symptoms that could indicate a postoperative recurrence, which was diagnosed three months after the procedure.

Conclusions

Pre-pubic urethrostomy can be successfully performed with the assistance of laparoscopy. The use of minimally invasive surgery will allow, in selected cases, removal of the urethral tumor, and in inoperable cases, to perform a minimally invasive palliative pre-pubic urethrostomy.
Effect of handholding on heart rate variability in both patients with cancer and their family caregivers: a randomized crossover study
Authors: Sakuma Hiroko , Hasuo Hideaki , Fukunaga Mikihiko
Published: September 2021

Background

Many family caregivers of patients with cancer feel guilty about self-care. A meaningful relationship with patients reduces such negative feelings and functions as self-care for family caregivers. Moreover, handholding improves autonomic functions in non-cancer patients. However, the effects of handholding on both patients with cancer and family caregivers remain unknown.

Methods

We evaluated the effects of handholding on heart rate variability (HRV) in patients with cancer and their family caregivers. This randomized crossover study divided patients with cancer and their family caregivers into two trial groups: Handholding trial (the family caregiver holds the patient’s hand for five minutes) and Beside trial (the family caregiver stays beside the patient without holding their hand). The study included 37 pairs of patients with cancer who received treatment in the cancer department of a university hospital in Japan and their family caregivers (n = 74). The primary end-point was the change in HRV before and during the intervention.

Results

The median performance status of the patients was 3. An interaction was observed between trials in the standard deviation of the normal-to-normal interval (SDNN) of HRV for family caregivers (F = 7.669; p = 0.006), and a significant difference in time course was observed between the trials (before p = 0.351; during p = 0.003). No interaction was observed between trials in the SDNN for patients (F = 0.331; p = 0.566). Only a main effect in time course (F = 6.254; p = 0.014) was observed. SDNN increased significantly during the intervention in both trials (Handholding trial: p = 0.002, Beside trial: p = 0.049).

Conclusions

Handholding improves autonomic functions of family caregivers and may function as self-care for family caregivers.

Trial registration

UMIN000020557. Registered on January 15, 2016.
ACE: a probabilistic model for characterizing gene-level essentiality in CRISPR screens
Authors: Hutton Elizabeth R. , Vakoc Christopher R. , Siepel Adam
Published: September 2021

High-throughput CRISPR-Cas9 knockout screens are widely used to evaluate gene essentiality in cancer research. Here we introduce a probabilistic modeling framework, Analysis of CRISPR-based Essentiality (ACE), that accounts for multiple sources of variation in CRISPR-Cas9 screens and enables new statistical tests for essentiality. We show using simulations that ACE is effective at predicting both absolute and differential essentiality. When applied to publicly available data, ACE identifies known and novel candidates for genotype-specific essentiality, including RNA m6-A methyltransferases that exhibit enhanced essentiality in the presence of inactivating TP53 mutations. ACE provides a robust framework for identifying genes responsive to subtype-specific therapeutic targeting.
Cognitive effectiveness of high-intensity interval training for individuals with methamphetamine dependence: a study protocol for randomised controlled trial
Authors: Menglu Shen , Suyong Yang , Xiaoyan Wang , Schöllhorn Wolfgang I. , Dong Zhu
Published: September 2021

Introduction

Cognitive deficit is a common syndrome of methamphetamine (MA) dependence. It is related to decision-making, control ability, and social functioning. High-intensity interval training (HIIT) is a training technique that requires people to work out at full intensity during a short period. Many studies have already shown the potential effects of HIIT on cognitive functions. The purpose of this trial is to evaluate the cognitive effects of HIIT on individuals with MA dependence.

Methods and analysis

A total of 240 individuals with MA dependence will be randomly assigned to the HIIT group, moderate-intensity continuous training (MICT) group and control (CON) group. HIIT will consist of a 24-min HIIT exercise on a treadmill. MICT will consist of a 1-h body–mind exercise. CON will be their traditional intervention. The experimental period will be 12 months with 3 interventions weekly for the first 6 months and follow-up for the next 6 months. All subjects will be given cognitive tests at baseline, after intervention and at follow-up. Cognitive performances will be compared by a mixed-model analysis for repeated measures.

Discussion

HIIT training may reduce illicit drug cravings amongst individuals with MA dependence; hence, HIIT may have a good effect on the cognitive functions, such as memory and executive function, of individuals with MA dependence.

Trial registration

Chinese Clinical Trial Registry ChiCTR2000032492. Registered on April 30, 2020 (http://www.chictr.org.cn/edit.aspx?pid=52127&htm=4)
Large dependency of intracellular NAD and CoA pools on cultivation conditions in Saccharomyces cerevisiae
Authors: Kumar Kanhaiya , Bruheim Per
Published: September 2021

Objective

The objective of this study was to investigate the variation of NAD and CoA metabolite pools in Saccharomyces cerevisiae cultivated under various cultivation conditions. This study complements a previous report on glycolytic, pentose phosphate pathway, tricarboxylic acid cycle, amino acids, and deoxy-/nucleoside phosphate pools determined under the same cultivation conditions.

Results

S. cerevisiae pellets from batch (four carbohydrate sources) and chemostat (carbon-, nitrogen-, phosphate—limited and a range of dilution rates) bioreactor cultivations were extracted and analyzed with two recently established absolute quantitative liquid chromatography mass spectrometry (LC–MS/MS) methods for NAD and CoA metabolites. Both methods apply 13C internal standard dilution strategy for the enhanced analytical accuracy and precision. Individual metabolite pools were relatively constant for the different growth rates within the same mode of cultivation, but large differences were observed among some of the modes, i.e. NAD metabolites were 10 to 100-fold lower in nitrogen limited chemostats compared to the other modes, and phosphate limited chemostats were characterized with much lower CoA metabolite pools. The results complement the previous results and together provide a comprehensive insight into primary metabolite pools variations at a large range in growth and carbon source consumption rates.
A longitudinal surgical systems strengthening research program for medical students: the exploration of a model for global health education
Authors: Peck Gregory L. , Hanna Joseph S. , Scott Erin M. , Mehta Dhaval , Model Zina , Sarma Deesha , Ginalis Elizabeth E. , Berlant Zachary , Ferrera Fernando , Escobar Javier , Ordoñez Carlos A. , Morales Carlos , Gracias Vicente H.
Published: September 2021

Background

In response to the staggering global burden of conditions requiring emergency and essential surgery, the development of international surgical system strengthening (SSS) is fundamental to achieving universal, timely, quality, and affordable surgical care. Opportunity exists in identifying optimal collaborative processes that both promote global surgery research and SSS, and include medical students. This study explores an education model to engage students in academic global surgery and SSS via institutional support for longitudinal research.

Objectives

We set out to design a program to align global health education and longitudinal health systems research by creating an education model to engage medical students in academic global surgery and SSS.

Program design and implementation

In 2015, medical schools in the United States and Colombia initiated a collaborative partnership for academic global surgery research and SSS. This included development of two longitudinal academic tracks in global health medical education and academic global surgery, which we differentiated by level of institutional resourcing. Herein is a retrospective evaluation of the first two years of this program by using commonly recognized academic output metrics.

Main achievements

In the first two years of the program, there were 76 total applicants to the two longitudinal tracks. Six of the 16 (37.5%) accepted students selected global surgery faculty as mentors (Acute Care Surgery faculty participating in SSS with Colombia). These global surgery students subsequently spent 24 total working weeks abroad over the two-year period participating in culminating research experiences in SSS. As a quantitative measure of the program’s success, the students collectively produced a total of twenty scholarly pieces in the form of accepted posters, abstracts, podium presentations, and manuscripts in partnership with Colombian research mentors.

Policy implications

The establishment of scholarly global health education and research tracks has afforded our medical students an active role in international SSS through participation in academic global surgery research. We propose that these complementary programs can serve as a model for disseminated education and training of the future global systems-aware surgeon workforce with bidirectional growth in south and north regions with traditionally under-resourced SSS training programs.
From flames to inflammation: how wildfires affect patterns of wildlife disease
Authors: Albery Gregory F. , Turilli Isabella , Joseph Maxwell B. , Foley Janet , Frere Celine H. , Bansal Shweta
Published: September 2021

Background

Fire strongly affects animals’ behavior, population dynamics, and environmental surroundings, which in turn are likely to affect their immune systems and exposure to pathogens. However, little work has yet been conducted on the effects of wildfires on wildlife disease. This research gap is rapidly growing in importance because wildfires are becoming globally more common and more severe, with unknown impacts on wildlife disease and unclear implications for livestock and human health in the future.

Results

Here, we discussed how wildfires could influence susceptibility and exposure to infection in wild animals, and the potential consequences for ecology and public health. In our framework, we outlined how habitat loss and degradation caused by fire affect animals’ immune defenses, and how behavioral and demographic responses to fire affect pathogen exposure, spread, and maintenance. We identified relative unknowns that might influence disease dynamics in unpredictable ways (e.g., through altered community composition and effects on free-living parasites). Finally, we discussed avenues for future investigations of fire-disease links.

Conclusions

We hope that this review will stimulate much-needed research on the role of wildfire in influencing wildlife disease, providing an important source of information on disease dynamics in the wake of future wildfires and other natural disasters, and encouraging further integration of the fields of fire and disease ecology.
Toxicity Index, Patient-Reported Outcomes, and Early Discontinuation of Endocrine Therapy for Breast Cancer Risk Reduction in NRG Oncology/NSABP B-35
Authors: Henry N. Lynn , Kim Sungjin , Hays Ron D. , Diniz Marcio A. , Luu Michael , Cecchini Reena S. , Yothers Greg , Rogatko André , Ganz Patricia A.
Published: September 2021

PURPOSE

The US National Cancer Institute Moonshot initiative calls for improving analysis and reporting of toxicity to inform treatment tolerability. We used existing clinician-reported adverse event (AE) and patient-reported outcome (PRO) questionnaire data from the randomized, double-blind NSABP B-35 clinical trial to explore reasons for anastrozole and tamoxifen discontinuation.

METHODS

Postmenopausal women with ductal carcinoma in situ treated with breast-conserving therapy were randomly assigned to anastrozole or tamoxifen for 5 years. The primary outcome for this analysis was time to treatment discontinuation. AEs were collected every 6 months post–random assignment from all 3,104 participants and summarized using the Toxicity Index (TI). PRO data were collected at baseline and every 6 months from 1,194 participants. Univariate and multivariable analyses of time to treatment discontinuation were performed using Cox regression models with TIs and PROs as time-dependent covariates.

RESULTS

Of 3,046 analyzed participants, 869 (28.5%) discontinued treatment prematurely. In multivariable analysis, when both baseline PROs and on-treatment AEs were considered, thrombosis and arthralgia AEs were associated with discontinuation of both tamoxifen and anastrozole; additional AEs associated with discontinuation varied by drug. In addition, baseline pain interference, hot flashes, and unhappiness were associated with tamoxifen discontinuation (n = 589; overall Harrell's C-statistic 0.686 [95% CI, 0.640 to 0.732]); no baseline PROs were associated with anastrozole discontinuation (n = 589; overall Harrell's C-statistic 0.656 [95% CI, 0.630 to 0.681]). When only baseline PROs were examined, pain interference, hot flashes, and unhappiness were associated with shorter time to discontinuation of tamoxifen; only hot flashes were associated with discontinuation of anastrozole.

CONCLUSION

Analysis of AEs using the TI yielded important insights into reasons for discontinuation of endocrine therapy that was enhanced by the addition of PRO baseline and treatment-emergent symptoms.
Turning Traitor: Shifting Loyalties in Procopius’ Gothic Wars
Authors: LILLINGTON-MARTIN Christopher , STEWART Michael Edward
Published: September 2021

Η αφήγηση του ιστοριογράφου Προκoπίου για τον πόλεμο εναντίον των Γότθων στην Ιταλία περιέχει πολλές περιπτώσεις Γότθων, Ιταλών και Ανατολικών Ρωμαίων που αλλάζουν παρατάξεις κατά τη διάρκεια της μακράς σύγκρουσης. Η συστηματική εξέταση του θέματος δείχνει ότι ο Προκόπιος γενικά αντιμετώπιζε με συγκατάβαση τους στρατιώτες που λιποτακτούσαν, στάση, που αντικατοπτρίζει τις ευρύτερες μεσογειακές αντιλήψεις του 6ου αιώνα. Τί μπορούν να μας διδάξουν τα παραδείγματα των «προδοτικών» συμπεριφορών σχετικά με τη διαφωνία στην εποχή του Ιουστινιανού; Παρόμοιες και άλλες πράξεις διαφωνίας από στρατιώτες υποδηλώνουν ότι μονάδες του στρατού του Ιουστινιανού –τουλάχιστον κατά τη διάρκεια του δυτικού πολέμου– είχαν κάποιο επίπεδο ελευθερίας του λόγου και της δράσης, που μερικές φορές τους επέτρεπε να υπαγορεύουν όρους είτε στον διοικητή τους είτε στην κεντρική κυβέρνηση στην Κωνσταντινούπολη. Με τον ίδιο τρόπο και η γοτθική αντίσταση στην Ιταλία, μπορεί να ερμηνευθεί ως μια πράξη μη συμμόρφωσης προς την πολιτική που τους αντιμετώπιζε ως βαρβάρους, χωρίς νόμιμη αξίωση για την Ιταλία.
Bibliographical Note: A. G. C. Savvides, “No rest for the wicked” [Isaiah 48:22 & 57:21]. On Isaac Ducas Comnenus’ Cypriot “separatist” state (A.D.1184/5-1191): The last of the Cypriot revolts against Byzantium (Papazissis Publishers: Athens, 2019).
Authors: EDBURY Peter
Published: September 2021

A. G. C. Savvides, “No rest for the wicked” [Isaiah 48:22 & 57:21]. On Isaac Ducas Comnenus’ Cypriot “separatist” state (A.D.1184/5-1191): The last of the Cypriot revolts against Byzantium (Papazissis Publishers: Athens, 2019).
AGREGAÇÃO DO ESTOQUE DE SEGURANÇA: ANÁLISE DE UMA EMPRESA CONSTITUÍDA POR TRÊS INSTALAÇÕES DE COMÉRCIO DE MADEIRA
Authors: Fonseca Renata Amaral , Moreira Filho Roberto Malheiros
Published: September 2021

A decisão de centralizar o estoque pode ser fundamental para o desempenho operacional e financeiro de empresas que possuem diferentes instalações distribuídas geograficamente. Este estudo investigou a vantagem na agregação do estoque de segurança de uma empresa composta por uma matriz e duas filiais. O produto analisado foi a madeira, utilizada principalmente na construção civil. A coleta de dados ocorreu por meio de entrevista e acesso a relatórios. Os históricos de venda foram analisados de maneira a avaliar o comportamento da demanda em cada loja e encontrar a distribuição contínua de probabilidade que melhor se adequa aos dados. A comparação entre o nível do estoque de segurança agregado e a soma dos estoques de segurança individuais sugere que a empresa percebe ganhos significativos ao decidir pela agregação. Apesar de o estudo ter se limitado ao estoque de segurança, entende-se que os ganhos poderiam ser ainda maiores se considerado também o estoque cíclico.
Direito à moradia no orçamento de Fortaleza: uma análise dos gastos públicos municipais com habitação de interesse social de 2010 a 2017 no contexto da implementação do Programa Minha Casa Minha Vida
Authors: Braga Felipe Albuquerque , Barbosa Guilherme Bezerra , Carvalho Harley Sousa de
Published: September 2021

O presente trabalho tem como objetivos analisar os investimentos realizados pelo município de Fortaleza em habitação de interesse social entre 2010 e 2017, compreender como o orçamento municipal se relaciona com a implementação do Programa Minha Casa Minha Vida e refletir sobre os impactos de tal relação no que diz respeito ao direito fundamental à moradia. Para tanto, em uma abordagem prioritariamente quantitativa, estuda-se os ciclos orçamentários compreendidos no período indicado, buscando apresentar e questionar as disposições das leis orçamentárias municipais para a função habitação. Realizou-se coleta de dados em planos plurianuais, leis de diretrizes orçamentárias, leis orçamentárias anuais, relatórios técnicos de prestação de contas do município, avaliações dos Planos Plurianuais e informações obtidas junto à Secretaria Nacional de Habitação do Ministério do Desenvolvimento Regional. Como resultado, identificou-se que, no período analisado, houve redução significativa na previsão e na execução do orçamento municipal para habitação, que o orçamento não incorporou efetivamente as diretrizes do Plano Diretor e que o Programa Minha Casa Minha Vida passou a centralizar as ações no tocante a política habitacional, em que pese a não aderência deste aos parâmetros de moradia adequada e aos preceitos do Plano Diretor de 2009.
Autorizar ou negociar? Os papéis do Conselho Municipal de Urbanismo na Política Urbana de Curitiba
Authors: Mafra Matheus , Isaguirre Katya Regina
Published: September 2021

Este estudo analisa aatuação do Conselho Municipal de Urbanismo (CMU), principal órgão responsável pela gestão do solo urbano de Curitiba, especificamente no que se refere aos parâmetros de construção e utilização do solo legislados através do planejamento urbano previamente pactuado. O objetivo central dessa empreitada é avaliar se o Conselho se enquadra nos parâmetros de gestão democrática estabelecidos desde o Estatuto da Cidade e qual seu perfil decisório em relação ao planejamento posto. Para atingir tal fim, utiliza-se da revisão bibliográfica e análise legislativa das principais normais definidoras do planejamento urbano de Curitiba. Complementa o método a análise documental das decisões emitidas pelo CMU durante o ano de 2016, utilizando-se de método quanti-qualitativo. Ambas análises demonstram a centralidade do Conselho na política urbana local e a importância da ampliação da sua democratização, haja vista seu perfil tecnocrata e hermético. Também demonstram a limitação da via legislativa para a consolidação do planejamento urbano, face as diversas demandas decorrentes do crescimento da cidade e de seu mercado imobiliário. Assim, reflexões de como promover decisões centralizadas na cidade e não na propriedade individual, além do fortalecimento de espaços não tecnocratas, são posturas essenciais para o fortalecimento de um planejamento urbano não excludente.
O direito da cidade: entre a segregação socioespacial e a busca por cidades sustentáveis
Authors: Bianchi Patricia Nunes Lima , Bodnar Zenildo , Gonçalves Junior Luiz Claudio
Published: September 2021

No artigo analisa-se, inicialmente, o direito à cidade sustentável sob o enfoque da complexidade, num contexto de segregação socioespacial. Em seguida, estabelece-se uma ligação entre a construção e desenvolvimento da cidade com a chamada injustiça socioambiental. Destaca-se, no estudo, a importância da realização de políticas públicas de desenvolvimento urbano com a participação da sociedade civil, com o propósito de se aperfeiçoar o bem-estar urbano da coletividade e de se construir, de fato, uma cidade sustentável. Conclui-se que, nesse processo, o Estado deverá melhor estruturar o seu poder regulador com relação ao capital das cidades, a fim de que este capital não se perpetue em benefício de uma elite, evitando-se, dessa forma, aumentar o desequilíbrio e as desigualdades nos centros urbanos. Por fim, a cidade deve iniciar um processo de transformação, mediante a construção de um programa político de reforma urbana direcionado ao atendimento às necessidades coletivas. No trabalho, utilizou-se o método de abordagem indutivo, método de procedimento monográfico e técnica de pesquisa bibliográfica.
Instrumentos para a avaliação do nível de consciência em adultos e idosos: revisão integrativa
Authors: Pires Fabiana Cristina , Vilaça Luana Vilela e , Pereira Caroline Bueno de Moraes , Ruiz Mariana Torreglosa , Ohl Rosali Isabel Barduchi , Chavaglia Suzel Regina Ribeiro
Published: September 2021

Objetivo: identificar na literatura evidências científicas sobre os instrumentos que avaliam o nível de consciência de pacientes adultos e idosos. Método: revisão integrativa de literatura, realizada em fevereiro de 2020, com artigos publicados entre 2010 e 2020, nas fontes de informação: LILACS, CINAHL, PubMed®/Medline, Web of Science, EBSCO e Scopus. Adotou-se o aplicativo Rayyan para a seleção dos estudos. Resultados: identificaram-se 884 artigos, destes, 19 atenderam aos critérios de inclusão. Foram identificadas oito escalas de avaliação. A maioria delas avalia os itens: abertura ocular, resposta motora, resposta verbal, padrão respiratório e reflexos tronco encefálicos. A escala Coma Recovery Scale-Revised foi a mais utilizada e a escala Full Outline of Unresponsiveness, considerada a mais completa para avaliar a consciência. Conclusão: verificou-se que as escalas possuem semelhança em seus domínios e mecanismos de avaliação e são confiáveis e efetivas para mensurar o nível de consciência de adultos e idosos.
Violência psicológica como mecanismo de censura dos direitos universais das mulheres
Authors: Siqueira Dirceu Pereira , Moraes Carlos Alexandre , Passafaro Valesca Oliveira
Published: September 2021

É proibida pela Constituição Federal do Brasil de 1988 (CF/88), mencionada no plano nacional, toda e qualquer forma de discriminação contra as mulheres. No seio de seu artigo 3º fica abertamente definido como principal alvo da República gerar sem que se faça qualquer distinção, o bem de todos e de todas, sem preconceito de raça, sexo, cor e idade. No artigo 5º da CF/88 do Brasil, antecipam que homens e mulheres são iguais em seus direitos e obrigações. E ainda, através da revisão dos 20 anos da Declaração e Plataforma de Ação da IV Conferência Mundial Sobre a Mulher, realizada na cidade de Pequim em 1995, os “Estados reunidos” que no mundo todo não existem nenhum lugar que se tenha igualdade de gênero.  Com essa constatação no mesmo ano, a adoção da agenda de 2030 para o desenvolvimento sustentável refletiu a cogente necessidade de combater em todo o mundo a desigualdade e discriminação contra todas as mulheres que, em decorrência, se tenha a violência como agente que limita a mulher a ter acesso ao seu desenvolvimento intelectual, profissional, liberdade, autônoma, participação política, educação e saúde. Nesse campo, vale ressaltar que este trabalho teve como objetivo demonstrar que a violência psicológica que estabelece na relação arbitraria de homens com as mulheres perpassa a destruição emocional, Autonomia, autoestima e o pleno desenvolvimento, batendo na esfera da destruição dos Direitos Universais das Mulheres. Isso, através de um sistema conhecido como Patriarcado o qual está enraizado na sociedade contemporânea através de séculos. Este sistema é um contrato ou pacto implícito de homens contra a igualdade de gênero. E que não permite as mulheres o alcance da cidadania e dos seus Direitos arrolados na Constituição Federal do Brasil e nos contratos Internacionais de Proteção à mulher. Este trabalho mostrou que a violência psicológica, ainda pouco comentada apesar da gravidade, é uma das violências primarias nas relações de abuso que em algum momento podem eclodir em morte dessas mulheres. Foi feito uma revisão bibliográfica para verificar as hipóteses aqui levantadas. E os resultados que obtivemos foi de que as relações de poder usam os mesmos mecanismos em que Hanna Harendt menciona em seu livro Da Violência, onde explica que para se manter uma ideologia (política) e submissão dos homens em detrimento de outros homens é necessária a violência, e a violência física será um instrumento usado quando todos os outros meios não forem o bastante. A isso, a violência psicológica a serviço da Estrutura Patriarcal serve como primeira expressão de violência para coibir mulheres para o alcance de sua liberdade, necessitando da violência física quando esta falhar, onde leva a quantidade de mortes de mulheres que vemos na atualidade.
Discricionariedade judicial e a indeterminabilidade dos princípios: por uma percepção de princípios para além das otimizações
Authors: Xavier Gustavo Silva , Iribure Júnior Hamilton Da Cunha
Published: September 2021

Este artigo tem como escopo a problematização do conceito e da proliferação dos princípios utilizados na prática jurídica brasileira para, a partir disso, discutir seu papel na redução dos espaços de discricionariedade judicial. Para tanto, percorre-se o seguinte itinerário: a) inicia-se com o célere debate entre Dworkin e Hart, demonstrando suas implicações; b) em um segundo momento, analisa-se a teoria dos princípios de Robert Alexy para, em seguida, confrontá-la com a teoria política de Ronald Dworkin; c) com base na obra de Rafael Thomas de Oliveira, apresentam-se os conceitos distintos que podem ser dados ao conceito de princípio, tais como i) princípios gerais do direito; ii) princípios jurídico-epistemológicos; iii) princípios pragmáticos-problemáticos, confrontando os primeiros com os princípios constitucionais; d) posteriormente, analisa o problema do panprincipiologismo; e) por fim, apresenta a institucionalização do mundo prático pelos princípios na Crítica Hermenêutica do Direito de Lenio Streck. Para serem alcançados tais objetivos, utilizam-se os aportes teóricos da Crítica Hermenêutica do Direito de Lenio Streck. Conclui-se que princípios (constitucionais) apresentam espaços argumentativos que permitem o controle das decisões judiciais, que retiram seu conteúdo normativo de uma vivência intersubjetiva emanada dos vínculos existentes na moralidade política da comunidade, sendo, pois, faticizados (vivenciados) pelos participantes da comunidade.
O minimalismo penal de Raúl Zaffaroni e um diálogo com a hermenêutica filosófica como caminhos para a reconstrução do sistema penal brasileiro
Authors: Paiva Matheus Maciel , Silva Filho Edson Vieira da
Published: September 2021

O presente artigo tem como proposta elucidar os principais aspectos do pensamento de Raúl Zaffaroni no que concerne precisamente ao seu modelo teórico de sistema criminal que, por sua vez, se enquadra no denominado minimalismo penal. No mesmo sentido, demonstrar a proximidade entre a proposta de Zaffaroni e o constitucionalismo brasileiro vigente, especificamente sob a perspectiva da hermenêutica filosófica. O método utilizado no geral é o analítico-descritivo, valendo-se de dados estatísticos para descrição da realidade político-criminal brasileira; além disso, deve-se ter em mente a fenomenologia presente principalmente nas etapas finais do artigo. Dois pontos nevrálgicos do pensamento do presente autor são o realismo marginal e o colonialismo/neocolonialismo; partindo basicamente destes dois elementos conclui-se a possibilidade de realizar um resgate da facticidade, da historicidade própria da realidade latino-americana, aspecto que converge com a proposta hermenêutica de bases fenomenológicas existencialistas, isto é, que tem como solo o arcabouço filosófico da analítica existencial ou ontologia fundamental. Por sua vez, compreende-se que a utilização da hermenêutica filosófica para compreensão e interpretação do texto constitucional é um caminho adequado para sanar a ruptura paradigmática atual, bem como reconstruir adequadamente um sistema criminal.
Hyperbaric oxygen treatment for University of Texas grade 3 diabetic foot ulcers: a retrospective cohort study
Authors: Lalieu Rutger C , Mulder Willem , Raap René D Bol , Stolk Saskia , Smit Casper , Dubois Emile FL , van Hulst Rob A
Published: September 2021

Aim:

Hard-to-heal diabetic foot ulcers (DFUs) may increase the risk of amputation. This study reports the positive influence of hyperbaric oxygen therapy (HBOT) on hard-to-heal DFUs involving underlying bone.

Method:

A single-centre, retrospective cohort study reporting the results of HBOT and wound care on hard-to-heal University of Texas grade 3 DFUs (i.e., involving underlying bone) between 2013 and 2019. Outcome measures were primarily (near-) complete wound healing (i.e., ≥80% ulcer surface area reduction) and amputation rate (minor or major), and secondarily the number of hyperbaric sessions and improvement in quality of life (QoL) and pain score.

Results:

The study included 206 patients, of whom 74 (36%) achieved complete wound healing, and 75 (36%) near-complete healing. Amputations were performed in 27 patients (13%): 12 (6%) minor and 15 (7%) major. The median number of HBOT sessions was 42. Participants who achieved complete healing received a median of 43 sessions, compared with 10 for those who required major amputation. Patients with at least 30 sessions were less likely to undergo amputation (odds ratio: 0.08; 95% confidence interval (CI): 0.03–0.21). Mean QoL increased by 7.6 points (95%CI: 3.9–11.3; p<0.01) and median pain score fell from 3 to 1 (0–3) (p<0.01).

Conclusions:

The addition of HBOT to standard wound care may lead to a decreased amputation risk, improved wound healing and increased QoL for people with a University of Texas grade 3 DFU. An adequate number of HBOT sessions is required to achieve optimal clinical results. Objective selection criteria and shared decision-making are suggested to improve dropout rates.
A guillotine amputation at the ankle level—how to quickly remove a septic foot: a case report
Authors: Ho Kristie , Arias Sandra , Roshan Donald , Dishner Katie , Lardizabal Marisse , Roth Bryan , Matthews Marc R
Published: September 2021

As of 2014, diabetes is estimated to affect 422 million people globally. It is well recognised that lower extremity amputations secondary to diabetes have a high mortality rate perioperatively. The purpose of this article is to provide a simple, step-by-step guide to surgeons who need to perform a transtibial amputation. The case report of a 62-year-old female patient with poorly controlled diabetes who developed necrotising fasciitis of the lower extremity and systemic sepsis is used to illustrate the procedure. Knowing how to complete this operation is essential due to its effectiveness in quickly eliminating a source of pedal sepsis.
There’s Something about Mary: Challenges and Prospects for Narrative Theodicy
Authors: Hernandez Jill Graper
Published: September 2021

This paper explores the constraints of narrative theodicy to account for the misery of the powerless and uses Mary of Bethany as a case study as evaluated through the early modern theodical writings of Mary Astell and Mary Hays. Eleonore Stump has pointed out that Mary of Bethany’s misery is interesting because it is so personal; it results from losing her heart’s desire. But, Mary of Bethany’s case fails as narrative theodicy because it cannot (unlike other cases, such as Job) sufficiently demonstrate the power of God in situated expressions of suffering, speak to plight of the powerless, nor put the sufferer in a stronger epistemic position. Astell and Hays provide a solution for the problem of lived experiences of systemic oppression for the project of narrative theodicy (it must be for and about suffering), and in so doing, remind us of the continued significance of their work to the philosophical canon. To succeed, narratives used for theodicy must speak directly to the plight of those who suffer, and must allow the powerless, miserable, unprivileged, and oppressed to have access to religious knowledge of the relationship between God and the one in misery, the one powerless.
Detachment Issues: A Dilemma for Beall’s Contradictory Christology
Authors: Page Meghan D.
Published: September 2021

Jc Beall offers a novel resolution to worries about Christ’s contradictory nature by introducing an account of logical consequence that allows for true contradictions. However, to prevent his view from exploding into heresy, Beall must deny that conditionals detach. But without detachment, the language fails to capture other true entailments which must be included in a complete account of Christ. Beall faces a dilemma, then, between heresy and inadequacy.
Power Management System of a Particle Swarm Optimization Controlled Grid Integrated Hybrid PV/WIND/FC/Battery Distributed Generation System
Authors: Praveen Kumar T. , Subrahmanyam N. , Sydulu Maheswarapu
Published: September 2021

In this manuscript, the Power management of grid integrated hybrid dis-tributed generation (DG) system with Particle swarm optimization (PSO)algorithm is proposed. The hybrid DG system combines with photovoltaic,wind turbine, fuel cell, battery. Depending on the use of hybrid sources andthe changes of power production the variation of power can occurs in the DGsystem. The major purpose of the proposed method restrains the power flow(PF) on active with reactive power between the source and grid side. In thepower system control the proposed PSO method is utilized to maximize theactive with reactive PF and the controllers. The proposed method interact theload requirement energy and maintain the load sensitivity due to chargingand discharging battery control. In the DG system, the proposed PSO methodallows maximum power flow. To assess the PF, the constraints of equalityand inequality have been evaluated and they are utilized to determine theaccessibility of renewable energy source (RES), electricity demand, and thestorage elements of charge level. The protection of the power system is enhanced based on the proposed PSO method. Additionally, for retaininga stable output the renewable power system and battery is used. The pro-posed method is activated in MATLAB/Simulink working platform and theefficiency is likened with other existing methods.
Low-Carbon Clean Technology for Waste Energy Recovery in Power Plants Based on Green Environmental Protection
Authors: Tian Yong , Liu Wen-Jing , Jiang Qi-jie , Xu Xin-Ying
Published: September 2021

With the development of biomass power generation technology, biomasswaste has a more excellent recycling value. The article establishes a biomasswaste inventory model based on the material flow analysis method andpredicts raw material waste’s energy utilization potential. The results showthat the amount of biomass waste generated from 2016 to 2020 is on therise. In 2020, biomass waste’s energy utilization can reach 107,802,300 tons,equivalent to 1,955.28PJ of energy. Through biomass energy analysis andemission analysis, the results show that the biomass waste can generate182.02 billion kW·h in 2020, which can replace 35.9% of the region’s totalpower consumption, which is compared with the traditional power generationmethod under the same power generation capacity. Power generation can reduce SO2 emissions by 250,400 tons, NOx emissions by 399,300 tons,and PM10 emissions by 49,700 tons. Reduce direct economic losses by712 million yuan. Therefore, Chinese promotion of the recycling of biomasswaste and the acceleration of the biomass energy industry’s development isof great significance for reducing pollutant emissions and alleviating energypressure.
Key Technology Optimization and Development of New Energy Enterprises of Photovoltaic Power Generation
Authors: Nan Jiangping
Published: September 2021

In order to improve the algorithm of time-varying parameters and unknownparameters adaptability, avoid assuming the approximate part deviationcaused by the algorithm, this paper proposes a adaptive control algorithm, thealgorithm based on lyapunov direct method to predict the output voltage inthe process of estimating each parameter in a reasonable manner to parameterestimation error with the actual output current and current automatic adjust-ment. The adaptive control of current tracking is realized and the error causedby assuming voltage or current and neglecting line resistance is avoided inthe predictive current control algorithm. The simulation results show thatthe tracking current can track the target current with high precision fromt = 0 in the presence of random noise, and the power factor is close to 1,showing a good steady-state performance. Frequency domain waveform, thecalculated harmonic distortion rate is 2.2418%, waveform quality is good andeach harmonic amplitude is small. Conclusion: adaptive control algorithmcan quickly and accurately realize current tracking and greatly suppress thenoise.
Urban policy: estate regeneration
Authors: Watt Paul
Published: September 2021

This chapter examines the shifting rationales and funding for estate regeneration in Britain with a focus on London. It provides an overview of urban renewal in both its old slum clearance form and new estate regeneration/demolition form. The chapter identifies an early estate regeneration period (1980s-90s) that included substantial public funding. However, from the late 1990s onwards, the private sector was increasingly expected to finance regeneration, while New Labour also emphasised creating mixed-tenure communities. The New Deal for Communities’ programme is discussed within this context. Rationales for comprehensive redevelopment are examined, including the roles played by neighbourhood effects and ‘sink estate’ place myth. The concept of entrepreneurial borough is introduced in relation to London and the entrepreneurial city (Harvey). The penultimate section identifies a key shift between earlier regeneration schemes (e.g. Comprehensive Estates Initiative in Hackney), and contemporary schemes (e.g. Heygate) which are the book’s primary focus. Whereas the former produced mixed-tenure neighbourhoods including limited private housing, 21st century regeneration schemes are estate densification projects which have resulted in distinct mixed-tenure neighbourhoods weighted towards market housing for sale rather than social renting – estate regeneration masquerading as state-led gentrification. The final section examines the financial and health costs of estate demolition.