bluuebunny/crossref_metadata_2025 huggingface dataset:
Brain metastasis from gastric adenocarcinoma: A large comprehensive population-based cohort study on risk factors and prognosis
Authors: Huang Lei , Wang Lei , Shi Yan , Zhao Yajie , Xu Chenying , Zhang Jun , Hu Weiguo
Published: October 2022

Aims

Although brain metastasis from gastric adenocarcinoma (GaC) is rare, it may significantly affect survival and quality of life. The aim of this large, comprehensive, population-based cohort investigation was to investigate factors that were associated with brain metastasis from GaC and to explore the prognostic factors and time-dependent cumulative mortalities among cases with GaC and brain involvement.

Methods

Population-based information on cases with GaC diagnosed from 2010 to 2016 was obtained from a large-scale database. Factors that were associated with brain metastasis were investigated utilizing multivariable logistic regression. Time-dependent tumor-specific mortalities of cases with GaC and brain involvement were then computed utilizing the cumulative incidence functions (CIFs), and mortalities were compared between subgroups utilizing Gray’s test. Factors that were associated with death were further evaluated utilizing multivariable Fine–Gray subdistribution hazard regression.

Results

Together, 28,736 eligible cases were included, which comprised 231 (1%) cases with brain metastasis and 10,801 (38%) with metastasis to other sites, encompassing a follow-up of 39,168 person-years. Brain metastasis occurred more often among younger patients (within overall cancers), in cases with stomach cardia tumors, within cases with signet-ring cell carcinoma (within overall cancers), and within cases with positive lymph nodes (within overall tumors); it was less often detected among black people. Brain involvement was associated with more lung and bone metastases. The median survival time of cases having brain metastasis was only 3 months; the 6- and 12-month tumor-specific cumulative mortalities were 57% and 71%, respectively. Among cases with GaC and brain metastasis, those with gastric cardia cancers (when receiving radiotherapy), those undergoing resection, and those receiving chemotherapy had lower mortality risks, while younger patients (when receiving chemotherapy or radiotherapy) and people with positive lymph nodes (when receiving radiotherapy) had higher death hazards.

Conclusion

Among patients with GaC, brain metastasis was correlated with several clinical and pathological variables, including ethnicity, age, cancer histology, location, lymph node involvement, and metastases to other sites. Cases having brain metastasis had poor survival that was correlated with age, cancer location, lymph node metastasis, and management. These findings offer vital clues for individualized patient care and future mechanistic explorations.
Impact through versatility: Patterns of in vivo dosimetry utilization with TLD across a large multi-site radiotherapy department
Authors: Lonski Peta , Kron Tomas
Published: October 2022

The complexity of modern radiotherapy treatment pathways necessitate input from different professions to ensure treatment is delivered safely and as planned. In vivo dosimetry is one method of treatment verification providing the opportunity for both in-field verification or out-of-field measurements. It was the aim of this work to review the impact of an in vivo dosimetry programme with t.he view to justify resources and assist in developing a plan for equipment acquisition. Results of 310 (approximately 2 per 1000 treatment fractions) in vivo measurements were reviewed over a two-year time span. The in vivo dosimetry programme using thermoluminescence (TLD) chips was able to detect three significant treatment errors, amongst some 13 000 patients treated. These errors would likely to have been undetected through other quality assurance measures. Increasing demands in workload were found to be associated with commissioning of new equipment and techniques. A skilled operator with knowledge of TLD physics, treatment planning system (TPS) dose calculation algorithms and radiation transport proved to be essential for appropriate interpretation of TLD results particularly in complex radiation delivery scenarios. TLD continues to play a large role in patient safety and quality assurance at our institution.
Thorax radiotherapy using 18F-positron emission tomography/computed tomography-guided precision radiotherapy is a prognostic factor for survival in patients with extracranial oligometastatic non-small cell lung cancer:A two-center propensity score-matched analysis
Authors: Liu Cheng-Sen , Song Ying-Qiu , Wang Run-Ze , Wang Zheng , He Rong , Xu Ke , Wang Chen-Yu , Wu Yu , Wang Ye , Zhang Xiao-fang , Li Guang , Wang Tian-Lu
Published: October 2022

Background

This retrospective study compared positron emission tomography (PET)/computed tomography (CT) and CT in the treatment of extracranial oligometastatic non-small-cell lung cancer (NSCLC) and explored the impact of thorax radiotherapy (TRT) on patient survival.

Methods

We reviewed the medical records of Chinese patients with stage IV extracranial oligometastatic NSCLC who underwent PET/CT or CT at two centers. Propensity score matching (PSM) was used to control differences in patient characteristics between the maintenance chemotherapy alone and TRT plus maintenance chemotherapy groups.

Results

We analyzed 192 eligible patients. The median survival time was better in patients who received PET/CT than in those who only received CT (n = 192, 16 months vs. 6 months, p<0.001). Subgroup analysis showed the median survival time was significantly longer in the TRT plus maintenance group than in the chemotherapy alone group in patients who underwent PET/CT examinations (n = 94, 25 months vs. 11 months, p<0.001). However, there was no statistical difference in survival between both groups in patients who underwent CT examinations (n = 98, 8 months vs. 5 months, p = 0.180). A multifactorial analysis revealed a more favorable prognosis in patients who underwent PET/CT evaluation (HR: 0.343, 95% CI: 0.250-0.471, p <0.001) and TRT (HR: 0.624, 95% CI: 0.464-0.840, p = 0.002), than in those who did not. PSM was consistent with these results.

Conclusions

PET/CT-guided TRT is associated with improved clinical outcomes in patients with stage IV extracranial oligometastatic NSCLC.
Efficacy of indocyanine green fluorescence imaging-guided lymphadenectomy in radical gastrectomy for gastric cancer: A systematic review and meta-analysis
Authors: Dong Bo , Zhang Anyuan , Zhang Yuqiang , Ye Wei , Liao Lan , Li Zonglin
Published: October 2022

Background

Indocyanine green (ICG) imaging-guided lymphadenectomy has been introduced in gastric cancer (GC) surgery and its clinical value remains controversial. The aim of this study is to evaluate the efficacy of ICG fluorescence imaging-guided lymphadenectomy in radical gastrectomy for GC.

Methods

Studies comparing lymphadenectomy in radical gastrectomy between use and non-use of ICG fluorescence imaging up to July 2022 were systematically searched from PubMed, Web of Science, Embase and Cochrane Library. A pooled analysis was performed for the available data regarding the baseline features, the number of retrieved lymph nodes (LNs), the number of metastatic LNs and surgical outcomes as well as oncological outcomes. RevMan 5.3 software was used to perform the statistical analysis. Quality evaluation and publication bias were also conducted.

Results

17 studies with a total of 2274 patients (1186 in the ICG group and 1088 in the control group) undergoing radical gastrectomy and lymphadenectomy were included. In the pooled analysis, the baseline features were basically comparable. However, the number of retrieved LNs in the ICG group was significantly more than that in the control group (MD = 7.41, 95% CI = 5.44 to 9.37, P < 0.00001). No significant difference was found between the ICG and control groups in terms of metastatic LNs (MD = -0.05, 95% CI = -0.25 to 0.16, P = 0.65). In addition, the use of ICG could reduce intraoperative blood loss (MD = -17.96, 95% CI = -27.89 to -8.04, P = 0.0004) without increasing operative time (P = 0.14) and overall complications (P = 0.10). In terms of oncological outcomes, the use of ICG could reduce the overall recurrence rate (OR = 0.50; 95% CI 0.28-0.89; P = 0.02) but could not increase the 2-year overall survival rate (OR = 1.25; 95% CI 0.72-2.18; P = 0.43).

Conclusions

ICG imaging-guided lymphadenectomy is valuable for complete LNs dissection in radical gastrectomy for GC. However, more high-quality randomized controlled trials are needed to confirm this benefit.
Leflunomide-induced pulmonary arterial hypertension in a young man with nephrotic syndrome: A case report
Authors: Luo Xiaoqin , Li Jiang , Chen Sisi , Luo Jun
Published: October 2022

Drug-induced pulmonary arterial hypertension (PAH) has been widely reported but PAH caused by leflunomide is very rare. Here we report the case of a young man with nephrotic syndrome treated with leflunomide for 5 years before being admitted to our hospital for dyspnea. After discontinuing leflunomide treatment for 4 months, both the dyspnea and pulmonary artery systolic pressure improved. Right heart catheterization showed in a significant decrease in pulmonary vascular resistance and pulmonary artery pressure 4 months later. Because persistent PAH can lead to right heart failure and even death, identifying and excluding the risk factors is critical; discontinuing leflunomide until a definite cause is identified is highly recommended.
Effect of replacing inorganic minerals with small peptide chelated minerals on production performance, some biochemical parameters and antioxidant status in broiler chickens
Authors: Kong Jing , Qiu Ting , Yan Xia , Wang Lili , Chen Zhiyong , Xiao Gengsheng , Feng Xin , Zhang Huihua
Published: October 2022

Due to the low bio-availability of inorganic trace minerals, its application in poultry production has been causing many problems such as environment pollution and waste of resources. The current study was designed to evaluate if replacing inorganic trace minerals (ITM) with small peptide chelate trace minerals (SPM) affects production performance, some biochemical parameters and antioxidant status, tibia mineral deposition, and fecal mineral content in 817 white-feathered broilers. A total of 432 broilers (21-day-old) were randomly divided into four groups with six replicates of 18 chicks each. The four groups included inorganic trace minerals group (addition of 1,000 mg/kg ITM; common practice by commercial poultry farms), three organic trace minerals groups with supplementation of 150, 300, and 500 mg/kg SPM, respectively. The experiment lasted for 30 days. The results showed that there was no significant difference in growth performance and slaughter performance among the four groups (p > 0.05). Total cholesterol in the SPM group was significantly lower than those in the ITM groups (p < 0.01). Compared with the ITM group, the serum urea nitrogen in 150 and 300 mg/kg SPM groups decreased significantly (p < 0.01). Among all SPM treatments, 300 mg/kg SPM groups had the highest serum glutathione peroxidase (GSH-Px) activity (p < 0.01). The activity of copper and zinc superoxide dismutase (Cu/Zn SOD) of liver in ITM group was the lowest among the four groups (p < 0.01). The catalase (CAT) activity of liver in the 150 mg/kg SPM group was significantly higher than the ITM group and 300 mg/kg SPM group (p < 0.05). Compared to the ITM group, the iron content of the tibia was significantly increased in 300 mg/kg SPM group (p < 0.05) and 500 mg/kg SPM group (p < 0.01). Compared to the ITM group, dietary supplementation with SPM significantly reduced fecal content of zinc and manganese (p < 0.01). The 150 mg/kg SPM and 300 mg/kg SPM group had significantly reduced content of iron (p < 0.05). This study demonstrated that replacing inorganic minerals with low doses of SPM (300 and 500 mg/kg) did not negatively affect growth and slaughter performance, as well as the antioxidant status of broiler chickens. In addition, SPM can also promote mineral content in the tibia and reduce mineral content in the feces.
Texture synthesis of ecological plant protection image based on convolution neural network
Authors: Hu Libing , Zhou Fei , Fu Xianjun
Published: October 2022

Texture synthesis technology is an important realistic rendering technology. Texture synthesis technology also has a good application prospect in image rendering and other fields. Convolutional neural network is a very popular technology in recent years. Convolutional neural network model can learn the features in data and realize intelligent processing through the feature learning in data. Later, with the rapid improvement of convolutional neural network, texture synthesis technology based on neural network came into being. The purpose of this paper is to study the texture synthesis method of ecological plant protection image based on convolutional neural network. By studying the context and research implications, the definition of textures as well as texture synthesis methods, convolutional neural networks, and based on convolutional neural network. In the experiment, the experimental environment is established, and the subjective evaluation and objective evaluation of the image texture synthesis method experiment are investigated and studied by using swap algorithm. The experimental results show that the method used in this paper is superior to other methods.
Analysis of the influence of enterprise managers’ overconfidence on the overinvestment behavior of listed companies under the media reports
Authors: So Michael
Published: October 2022

At present, there is a common overinvestment behavior among listed companies in various countries, which seriously reduces the overall resource allocation efficiency of the market. With the rise of behavioral finance, it has become a new direction to study the influence of managers’ “irrational characteristics” on enterprise overinvestment. With the rapid rise of the media industry, media reporting, as an external governance mechanism, supplements the capital market supervision system and has a huge impact on the investment behavior of enterprises. How media reports affects overinvestment and whether it can curb overinvestment caused by managers’ overconfidence is still worthy of further study. This paper took 6,012 A-share listed companies from 2013 to 2021 as samples, and based on the perspective of “media reports,” studies the impact of managers’ overconfidence on overinvestment; explores whether positive and negative media reports have a moderating effect between overconfidence and overinvestment; studies the moderating effect of media reports under different marketization processes. Empirical conclusions: (1) Managers’ overconfidence will lead to overinvestment of enterprises. (2) Positive media reports will aggravate the overinvestment caused by managers’ overconfidence; negative reports can inhibit the overinvestment caused by managers’ overconfidence. (3) In regions with higher marketization, positive media reports play a more significant role in aggravating overconfidence and leading to overinvestment; in regions with lower marketization, negative reports play a stronger role in restraining overconfidence and overinvestment.
How does the Internet enhance the subjective well-being of elderly individuals in China?
Authors: Dong Xuebing , Meng Shunjie , Chen Danbo
Published: October 2022

Although several studies have explored the relationship between the Internet and elderly individuals, little is known about whether and how the Internet affects elderly individuals’ subjective well-being (SWB) from multiple perspectives. This study examines the effects of the Internet on physical satisfaction and life satisfaction and explores the potential mechanisms by which the Internet produces its effects on elderly individuals. Using nationally representative data from the China General Social Survey (CGSS), this study finds that the Internet has a significant positive impact on physical satisfaction and life satisfaction of the elderly in China. The mechanism analysis shows that the Internet can improve the level of health insurance participation, which we interpret as potential mechanisms through which the Internet positively affects physical satisfaction among elderly individuals. Correspondingly, the Internet affects life satisfaction of elderly individuals by influencing social networks. Further heterogeneity tests find that the effect is stronger for urban areas, male and high human capital samples. This study highlights the important micro effects of the Internet and provides a reference for exploring the mechanism of the Internet affecting SWB.
Primary and middle-school children’s drawings of the lockdown in Italy
Authors: Capurso Michele , Buratta Livia , Mazzeschi Claudia
Published: October 2022

This retrospective-descriptive study investigated how primary and middle-school children perceived the first COVID-19 lockdown in Italy (March–May 2020) as manifested in their drawings. Once school restarted after the first COVID-19 wave, and as part of a structured school re-entry program run in their class in September 2020, 900 Italian children aged 7–13 were asked to draw a moment of their life during the lockdown. The drawings were coded and quantitatively and qualitatively analyzed; several pictorial examples are illustrated in this article. Most children used colorful and full-body representations of the self, but in almost half of the pictures drawn by older students, the self was either missing or represented without the face visible. Most children drew the interior of their houses, and the outside world was completely invisible in over half of the pictures. The most represented activities among younger students were playing or sport, followed by screentime or technology-use. Domestic routines and distance learning were also depicted. Most children, but predominantly girls, drew characters showing emotional cohesion clues, and more younger pupils and girls depicted contentment as their main emotion. Conflicting emotions were virtually non-existent. Our data suggest that children coped with the lockdown through play, screen, and technology use. The high incidence of the missing self-representation in preadolescents could indicate how the enforced loneliness and lack of direct physical contact with others impacted their perception of the self. The findings presented here deepen our knowledge of the dynamics connected to the effects of the COVID crisis on children and young people and show how drawings can provide a valuable window into children’s emotions and perceptions.
Estimations of child linguistic productivity controlling for vocabulary and sample size
Authors: Aguado-Orea Javier
Published: October 2022

Children’s use of present tense suffixes is less productive than that of their parents, after correcting for sample size and lexical knowledge, according to a recently established approach for the study of inflectional productivity. This article expands on this technique by providing precise estimates of early grammatical productivity through systematic random sampling and allowing for developmental assessment. Two cross-linguistic comparisons are given in the results of this study. Two Spanish-speaking children and their parents are compared with four English-speaking children and their parents. The second comparison examines potential differences in productivity throughout developmental stages using the same six children’s speech. The findings indicate that Spanish-acquiring children are less productive than their parents while utilising the paradigm under study, but that productivity levels increase over time. In contrast, the English-speaking children’s morphosyntactic production mirrors that of their parents. Although the primary focus of this research is methodological, these findings have consequences for theoretical theories arguing either rule abstraction or a restricted generalisation of early exemplars.
A national-level analysis of life expectancy associated with the COVID-19 pandemic in India
Authors: Muniyandi Malaisamy , Singh Pravin Kumar , Aanandh Yamini , Karikalan Nagarajan , Padmapriyadarsini Chandrasekaran
Published: October 2022

Background

From a demographic perspective, the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on life expectancy is not clear. Hence, there is a need to study the number of years of life lost concerning the existing average life expectancy due to COVID-19 in India.

Objective

This study aimed to estimate the impact of life expectancy due to the COVID-19 pandemic in India.

Methodology

We considered day-wise age-specific mortality due to COVID-19 which was extracted from the COVID-19 data repository from March 11, 2020, to June 30, 2021, in India. All-cause mortality was collected from the United Nations population estimates. An abridged life table technique was utilized for calculating life expectancies based on all-cause mortality and mortality due to COVID-19. MortPak software was used to calculate the life expectancy with and without the COVID-19 pandemic. Life expectancy at birth in different age groups was estimated with respect to with and without COVID-19.

Results

A total of 399,459 deaths due to COVID-19 were distributed age wise, and their corresponding life expectancy was calculated. The general mortality was compared with COVID-19 mortality for the various age groups, and it was observed that mortality due to COVID-19 was significantly higher among the elderly age group [i.e., 45 to 60 years (36%) and > 60 years (51%)] when compared with < 25 years (1%) and 26–44 years (11%) (trend Chi-square 7.59; p = 0.001). The life expectancy without and with COVID-19 was 69.28 years and 69.16 years, respectively.

Conclusion

Overall, it was estimated that COVID-19 has an impact on life expectancy by 0.12 years during the study period. Even though mortality due to COVID-19 was high, factors such as lockdown, vaccination, and accidents also had an influence on mortality. Thus, there is a need to assess the impact of COVID-19 on life expectancy in future.
Judgment aggregation, discursive dilemma and reflective equilibrium: Neural language models as self-improving doxastic agents
Authors: Betz Gregor , Richardson Kyle
Published: October 2022

Neural language models (NLMs) are susceptible to producing inconsistent output. This paper proposes a new diagnosis as well as a novel remedy for NLMs' incoherence. We train NLMs on synthetic text corpora that are created by simulating text production in a society. For diagnostic purposes, we explicitly model the individual belief systems of artificial agents (authors) who produce corpus texts. NLMs, trained on those texts, can be shown to aggregate the judgments of individual authors during pre-training according to sentence-wise vote ratios (roughly, reporting frequencies), which inevitably leads to so-called discursive dilemmas: aggregate judgments are inconsistent even though all individual belief states are consistent. As a remedy for such inconsistencies, we develop a self-training procedure—inspired by the concept of reflective equilibrium—that effectively reduces the extent of logical incoherence in a model's belief system, corrects global mis-confidence, and eventually allows the model to settle on a new, epistemically superior belief state. Thus, social choice theory helps to understand why NLMs are prone to produce inconsistencies; epistemology suggests how to get rid of them.
No sex-specific effects of balance training on dynamic balance performance in healthy children
Authors: Muehlbauer Thomas , Schedler Simon
Published: October 2022

Background

Cross-sectional studies in children reported better balance performance for girls than for boys. Thus, balance trainability might be different between female and male children. The aim of the present study was to examine the effects of balance training (BT) on dynamic balance performance in girls compared to boys.

Methods

Seventeen girls (age: 11.1 ± 0.7 years) and 22 boys (age: 11.1 ± 0.8 years) were assigned to either a BT-group or an active control (CON) group. BT was conducted over eight weeks (two sessions/week) while the CON-groups received their regular physical education lessons during the same period. Before and after treatment, dynamic balance performance was assessed by using the Lower Quarter Y-Balance (YBT-LQ) test. A series of three-way analyses of covariance (ANCOVA) were undertaken to test for within-between effects of Test [×2 (pretest vs. posttest)], Group [×2 (BT-group vs. CON-group)] and Sex [×2 (boys vs. girls)].

Results

The three-way ANCOVA yielded a significant main effect of Test (p = 0.002–0.043, ηp2 = 0.122–0.262) and of Group (all p < 0.001, ηp2 = 0.330–0.651) but not of sex for all YBT-LQ reach directions and the composite score. Further, there were significant Test × Group interactions (all p < 0.001, ηp2 = 0.330–0.651) in favor of both BT-groups but neither Test × Sex nor Test × Group × Sex interactions were detected.

Conclusions

We conclude that BT is an effective treatment to improve dynamic balance performance in healthy children regardless of their sex. Consequently, girls and boys can be provided with the same BT regime to enhance their postural control.
Activism for intersectional justice in sport sociology: Using intersectionality in research and in the classroom
Authors: Calow Emma
Published: October 2022

This perspective paper considers what scholars and teachers of sport sociology can (un)learn by applying the concept of intersectionality in research and in the classroom. I focus on contemporary forms of activism in the context of sport in the United States (U.S.) and demonstrate intersectionality's utility through three examples of athlete activism from the past 10 years led by sports people. Although each example is focused on a particular axis of difference and domination, such as sexual harassment (read: gender) and Black Lives Matter (read: race), I show that the cause at stake is always already intersectional. This has consequences for the field of sport studies/sport sociology; in engaging in intersectional research, sport sociologists and researchers alike can inform policymakers in sport in the decision-making process. In the final part of the paper, I offer insight from my positionality as a graduate student through reflection on how I—and my colleagues—might understand our role within the “matrix of domination” that characterizes both our subject and our field. As novice sport scholars, graduate students can translate the theoretical meanings and purpose of intersectionality into lived reality by being intentional in what and how we teach and research. In this case, I suggest that intersectional justice in sport does not just mean on the track/field/court; it can also mean in the classroom, thereby expanding our notion of what activism “in sport” is and looks like.
Comparison of the efficacy of expandable interbody fusion cage (EXP-IFC) and non-expandable interbody fusion cage (NE-IFC) in MIS-TLIF for lumbar degenerative diseases: A systematic retrospective study on 62 patients
Authors: Chen Chen , Li Qiang , Wang Wei , Ji Chunlei , Kang Yi , Wang Chaoyu , Zhang Hongyi , Zhang Ming , Zhou Hengxing , Feng Haoyu , Feng Shiqing
Published: October 2022

Objectives

To investigate the clinical and radiographic outcomes of EXP-IFC in single-level MIS-TLIF.

Methods

This study included patients aged ≥18 years who received a single-level MIS-TLIF procedure with at least 1 year of follow-up. Outcome measures: clinical features, preoperative and neurological complications. Imaging analysis included disc height (DH) restoration, surgical and contralateral side foraminal height (FH), lumbar lordosis angle (LL), segmental lordosis (SL). Visual analog scale (VAS) score for low back pain (VAS-LBP) and leg pain (VAS-LP), Oswestry Disability Index (ODI) and Japanese Orthopaedic Association (JOA) score were used to evaluate clinical outcomes. Statistical analysis was performed using independent sample t-test and sample t-test. The significance was set to p < 0.05 in univariate analysis.

Results

A total of 62 patients undergoing single level MIS-TLIFs between January 2017 and January 2019 were included, with 32 NE-IFC 46.9% female, mean age 54.86 ± 11.65, mean body mass index (BMI) 24.59 ± 3.63) and 30 EXP (40% female, mean age 58.32 ± 12.99, mean BMI 24.45 ± 2.76) with no significant differences in demographics. There were no significant differences between two groups in Operative time (OT), Estimated blood loss (EBL) and Length of stay (LOS). No significant differences were found in VAS-LBP, VAS-LP, JOA and ODI in post-operation and the last follow-up between the two groups. The imaging outcome demonstrated that the mean increase in DH was significantly greater for the patients with EXP-IFC than those with NE-IFC group at 1 year follow-up (8.92 ± 0.51 mm EXP-IFC vs. 7.96 ± 0.96 mm NE-IFC, p < 0.001). The mean change in FH of operative and contralateral sides were observed to be significantly higher for the patients with EXP-IFC at 1 year follow-up (operative side:17.67 ± 2.29 mm EXP-IFC vs. 16.01 ± 2.73 mm NE-IFC, p = 0.042; contralateral side:17.32 ± 2.26 mm EXP-IFC vs. 16.10 ± 2.32 mm NE-IFC, p < 0.001), but changes in LL and SL were not significantly different. At the last follow-up, we did not find any significant difference in the fusion rate between the two groups.

Conclusion

Our results indicated that there may be no significant difference in short-term clinical outcomes between EXP-IFC and NE-IFC, but the use of EXP-IFC in MIS-TLIF can provide a significant restoration of disc height, and neural foraminal height compared to NE-IFC.
Choice of injection time of conscious sedation and its impact on pain control in colonoscopy
Authors: Su Mingli , Chen Tingting , Zhong Qinghua , Lin Dezheng , Liu Wei , Su Yuping , Deng Jiaxin , Zhang Jiawei , Hu Jiancong , Guo Xuefeng
Published: October 2022

Purpose

The aim of this study was to identify the effect of different injection times on pain during colonoscopy procedure.

Methods

In this retrospective study, the data of patients who underwent colonoscopy from June 2020 to September 2020 were assessed to investigate the effect of different injection time of sedative drugs (midazolam and dezocine). The primary endpoint was evaluating the pain intensity of the patients using visual analogue scale (VAS) immediately after colonoscopy .

Results

A total of 152 patients were eligible for this study. Of them, 76 received midazolam and dezocine injection 1 min prior to the colonoscopy procedure (the 1 Min group) and the other 76 patients received the injection 3 min prior to the procedure (the 3 Min group). The vital signs of all patients were stable except for one patient who was diagnosed with inflammatory bowel disease in the 3 Min group. A transient drop in blood pressure for this patient was observed during colonoscopy but returned to normal after general treatment. The two groups had similar rates of cecal intubation (84.21% vs. 90.97%, P = 0.22), addition of sedative drugs during procedure (2.63% vs. 5.26%, P = 0.68), and adequate bowel preparation (Boston Bowel Preparation Scale ≥6, 61.84% vs. 61.84%, P = 1.0). However, patients in the 3 Min group had significantly lower VAS than those in the 1 Min group [0 (0, 1) vs. 1 (0, 2), P = 0.041].

Conclusion

The timing of drug injection during conscious sedation may affect pain control during colonoscopy, with 3 min prior to the procedure showing lower VAS.
Comparative evaluation of mineral profiles in different blood specimens of dairy cows at different production phases
Authors: Hussein Hussein Awad , Müller Anja-Elivera , Staufenbiel Rudolf
Published: October 2022

Background

Evaluation of mineral profiles including essential and toxic elements in dairy cows provides fundamental information for bovine practitioners during regular herd supervision and monitoring. The present research was designed to investigate the variations of mineral profiles in different blood specimens of dairy cows at different lactation stages.

Methods

This study was divided into two parts: the first included 32 cows, which were classified into four groups according to their lactation stages, and the second involved 10 cows at mid-lactation. The concentrations of copper (Cu), zinc (Zn), selenium (Se), manganese (Mn), barium (Ba), strontium (Sr), calcium (Ca), magnesium (Mg), total phosphorous (P), sulfur (S), cobalt (Co), silicon (Si), lithium (Li), nickel (Ni), thallium (Tl), boron (B), aluminum (Al), uranium (U), and arsenic (As) were measured in serum, ethylene diamine tetraacetic acid (EDTA) plasma, heparin plasma, and EDTA whole blood samples.

Results

The concentrations of Cu, Zn, Fe, Mn, Ba, and Sr showed significant variations among the dairy cows of different lactation stages (p < 0.05). Strong regressions were determined between the mineral concentrations in individual and pooled samples (R2 = 0.991, p = 0.000). In comparison to other blood sample types, the concentration of Cu, Ba, and Sr was higher in EDTA plasma (p < 0.000). In addition, the values of Zn, Se, Fe, and Mn were significantly increased in heparin and EDTA whole blood samples. Concentrations of Ca and Mg, and P were higher in EDTA plasma, and EDTA whole blood samples, respectively. Furthermore, the mean values of Si, Li, Ni, and Tl showed significant increases in EDTA plasma, while S values were higher in EDTA whole blood samples (p < 0.000). Concentrations of Al and U exhibited significant increases in serum samples (p < 0.000).

Conclusion

Concentrations of Cu, Zn, Fe, Mn, Ba, and Sr undergo physiological variations among dairy cows at different lactation stages. Therefore, caution should be taken during assessment of these minerals. The concentrations of essential and toxic elements, as well as Ca, P, Mg, and S, varied among the different blood sample specimens, indicating their interpretations should be based on this regard. During dairy herd supervision, the use of pool sample, instead of individual ones, for determination of mineral status may be promising to minimize the costs of individual sample measurements. In general, EDTA plasma may be more suitable for measurements of Ca, Mg, P, and S. It seems that EDTA plasma and heparinized plasma are suited for the estimation of Se and Fe, respectively.
Fair Benchmark for Unsupervised Node Representation Learning
Authors: Guo Zhihao , Chen Shengyuan , Huang Xiao , Qian Zhiqiang , Yu Chunsing , Xu Yan , Ding Fang
Published: October 2022

Most machine-learning algorithms assume that instances are independent of each other. This does not hold for networked data. Node representation learning (NRL) aims to learn low-dimensional vectors to represent nodes in a network, such that all actionable patterns in topological structures and side information can be preserved. The widespread availability of networked data, e.g., social media, biological networks, and traffic networks, along with plentiful applications, facilitate the development of NRL. However, it has become challenging for researchers and practitioners to track the state-of-the-art NRL algorithms, given that they were evaluated using different experimental settings and datasets. To this end, in this paper, we focus on unsupervised NRL and propose a fair and comprehensive evaluation framework to systematically evaluate state-of-the-art unsupervised NRL algorithms. We comprehensively evaluate each algorithm by applying it to three evaluation tasks, i.e., classification fine tuned via a validation set, link prediction fine-tuned in the first run, and classification fine tuned via link prediction. In each task and each dataset, all NRL algorithms were fine-tuned using a random search within a fixed amount of time. Based on the results for three tasks and eight datasets, we evaluate and rank thirteen unsupervised NRL algorithms.
Newest Therapies for Cholangiocarcinoma: An Updated Overview of Approved Treatments with Transplant Oncology Vision
Authors: Zhang Yuqi , Esmail Abdullah , Mazzaferro Vincenzo , Abdelrahim Maen
Published: October 2022

A minority of cholangiocarcinoma (CCA) can be cured by surgical intervention (i.e., liver resection (LR) and liver transplantation (LT)). When modern criteria for LT are met, this intervention along with neoadjuvant treatments may achieve unprecedented survival in selected patients. Liver resection is associated with a median overall survival (OS) of 40 months, this number drastically decreases for unresectable advanced cholangiocarcinoma (CCA), which is treated with systemic therapy. The first-line chemotherapy regimen of gemcitabine and cisplatin is associated with a median overall survival of only 11.7 months. Since the Food and Drug Administration (FDA)’s approval of the isocitrate dehydrogenase (IDH) 1 inhibitor ivosidenib in August 2021, there has been increasing interest in targeted therapy for CCA patients harboring mutations in fibroblast growth factor receptor (FGFR) 2, neurotrophic receptor tyrosine kinase (NTRK), B-raf kinase (BRAF), and HER2. At the same time, immunotherapy with immune checkpoint inhibitors isalso being used in relapsed CCA. This review looks into the most recently completed and ongoing studies of targeted therapy as monotherapy or in combination with chemo- and/or immunotherapy. Whether it is resection, liver transplant, radiotherapy, chemotherapy, immunotherapy, targeted therapy, or any combination of these treatment modalities, great strides are being made to improve outcomes for this challenging disease.
Radiomic and Volumetric Measurements as Clinical Trial Endpoints—A Comprehensive Review
Authors: Funingana Ionut-Gabriel , Piyatissa Pubudu , Reinius Marika , McCague Cathal , Basu Bristi , Sala Evis
Published: October 2022

Clinical trials for oncology drug development have long relied on surrogate outcome biomarkers that assess changes in tumor burden to accelerate drug registration (i.e., Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) criteria). Drug-induced reduction in tumor size represents an imperfect surrogate marker for drug activity and yet a radiologically determined objective response rate is a widely used endpoint for Phase 2 trials. With the addition of therapies targeting complex biological systems such as immune system and DNA damage repair pathways, incorporation of integrative response and outcome biomarkers may add more predictive value. We performed a review of the relevant literature in four representative tumor types (breast cancer, rectal cancer, lung cancer and glioblastoma) to assess the preparedness of volumetric and radiomics metrics as clinical trial endpoints. We identified three key areas—segmentation, validation and data sharing strategies—where concerted efforts are required to enable progress of volumetric- and radiomics-based clinical trial endpoints for wider clinical implementation.
Establishment and Characterization of a New Human Intrahepatic Cholangiocarcinoma Cell Line LIV27
Authors: Ding Xiwei , Zakharia Kais , Moser Catherine D. , Campbell Nellie A. , Hu Chunling , Razumilava Nataliya , Chaiteerakij Roongruedee , Shaleh Hassan M. , Greipp Patricia T. , Graham Rondell P. , Zou Xiaoping , Chandan Vishal S. , Roberts Lewis R.
Published: October 2022

Cholangiocarcinoma (CCA) is a highly lethal cancer arising from the biliary tract epithelium. The cancer biology of this neoplasm is not well understood. To date, only a few CCA cell lines have been reported, which were mostly developed from Asian patients. In this study, we report and characterize a new intrahepatic CCA cell line, LIV27, derived from a surgically resected tumor in a 67-year-old Caucasian woman with primary sclerosing cholangitis (PSC). LIV27 cells grow well in collagen-coated flasks or plates with a doubling time of 57.8 h at passage 14. LIV27 cells have high tumorigenicity in nude mice and stain positive for CK7 and CK19, markers that differentiate CCA from hepatocellular carcinoma. Karyotype analysis showed that LIV27 is aneuploid. We established a single-locus short tandem repeat profile for the LIV27 cell line. This newly established cell line will be a useful model for studying the molecular pathogenesis of, and developing novel therapies for, cholangiocarcinoma.
Mediating Effects of Diagnostic Route on the Comorbidity Gap in Survival of Patients with Diffuse Large B-Cell or Follicular Lymphoma in England
Authors: Smith Matthew , Rachet Bernard , Luque-Fernandez Miguel
Published: October 2022

Background: Socioeconomic inequalities in survival from non-Hodgkin lymphoma persist. Comorbidities are more prevalent amongst those in more deprived areas and are associated with diagnostic delay (emergency diagnostic route), which is also associated with poorer survival probability. We aimed to describe the effect of comorbidity on the probability of death mediated by diagnostic route (emergency vs. elective route) amongst patients with diffuse large B-cell (DLBCL) or follicular lymphoma (FL). Methods: We linked the English population-based cancer registry and hospital admission records (2005–2013) of patients aged 45–99 years. We decomposed the effect of comorbidity on survival into an indirect effect acting through diagnostic route and a direct effect not mediated by diagnostic route. Furthermore, we estimated the proportion of the comorbidity effect on survival mediated by diagnostic route. Results: For both DLBCL (n = 27,379) and FL (n = 14,043), those with any comorbidity, or living in more deprived areas, were more likely to experience diagnostic delay and poorer survival. The indirect effect of comorbidity on mortality through diagnostic route was highest at 12 months since diagnosis (DLBCL: Odds Ratio 1.10 [95% CI 1.07–1.13], FL: OR 1.09 [95% CI 1.04–1.14]). Within the first 12 months since diagnosis, emergency diagnostic route accounted for 24% (95% CI 17.5–29.5) and 16% (95% CI 6.0–25.6) of the comorbidity effect on mortality, for DLBCL and FL, respectively. Conclusion: Efforts to reduce diagnostic delay (emergency diagnosis) amongst patients with comorbidity would reduce inequalities in DLBCL and FL survival by 24% and 16%, respectively. Further public health programs and interventions are needed to reduce diagnostic delay amongst lymphoma patients with comorbidities.
Meiotic Analysis of Gomphidae Species Sheds Light on the Large X Chromosome of the Family (Anisoptera, Odonata)
Authors: Mola Liliana M. , Rebagliati Pablo J. , Fourastié María F. , Agopian Silvia S.
Published: October 2022

In most Anisoptera families, the modal diploid number is 25 in males (24 autosomes + X), and the X chromosome is one of the smallest elements of the complement. The family Gomphidae is an exception, as it has a modal diploid number of 23 (22 + X), and the X chromosome is the largest of the complement and of medium-to-large size in many species. We studied the meiosis of three gomphid species from Argentina: Aphylla cf. distinguenda (Campion, 1920), Phyllocycla propinqua Belle, 1972 and Phyllocycla sp. Chromosome number is 2n = 23, n = 11 + X, except for Phyllocycla propinqua, showing n = 10 + X. The X chromosome of these species is medium-sized and presents heteropyknotic blocks of different sizes. Despite the small number of gomphid species analysed, there is a clear trend of increasing size of the X chromosome with the increasing amount of heterochromatin. Our results, together with those from the literature, suggest that its large size might have been due to a progressive accumulation of repetitive DNA and heterochromatinisation and not to fusion, as previously suggested. This led us to propose that the ancestral number coincided with the modal number of Gomphidae. A revision of the derived sex-determining systems in Odonata is also provided.
Features of Radial Growth Rate of Trees in Agro-Pastoral Transition Zone, Northern China
Authors: Sun Jiayu , Liu Na , Bao Guang , Wang Yanchao , Chu Qi
Published: October 2022

The Vaganov–Shashkin process-based model was used to explore the variation characteristic of the radial growth rate of Pinus tabulaeformis in the agro-pastoral transition zone in northern China. The tree-ring width chronologies of the four sampling sites were significantly positively correlated with the simulated series (p < 0.01), and the simulated onset and end dates of tree radial growth indicated that April to October was the main growing season. Temperature affects the radial growth rate of tree stems at the start and end of the growing season, while soil moisture availability affects the radial growth rate in the main growing season. Despite the differences in amplitude, the integral growth rate showed a bimodal pattern, which to some extent responded to the hydrothermal configuration of the East Asian summer monsoon climate. Compared with the peak changes in the summer monsoon fringe area in Northwest China, the highest peak of the integral growth rate in this study area appeared around August in the late growing season, reflecting the adaptability of trees to the local climatic environment. The average values of the integral growth rate and rate due to soil moisture, inferred from extreme wide-ring and narrow-ring years, were significantly different (p < 0.01), while the average growth rates due to temperature were not significant (p > 0.05). The analysis results indicate that moisture availability is a key limiting factor for the radial growth of Pinus tabulaeformis. Our study provides valuable knowledge about the growth processes of the main tree species related to the hydroclimatic variables in northern China and offers a new perspective on mitigating the adverse effects of a warmer climate on the forest in the semi-arid region in the future.
Hereditary Metabolic Bone Diseases: A Review of Pathogenesis, Diagnosis and Management
Authors: Charoenngam Nipith , Nasr Aryan , Shirvani Arash , Holick Michael F.
Published: October 2022

Hereditary metabolic bone diseases are characterized by genetic abnormalities in skeletal homeostasis and encompass one of the most diverse groups among rare diseases. In this review, we examine 25 selected hereditary metabolic bone diseases and recognized genetic variations of 78 genes that represent each of the three groups, including sclerosing bone disorders, disorders of defective bone mineralization and disorder of bone matrix and cartilage formation. We also review pathophysiology, manifestation and treatment for each disease. Advances in molecular genetics and basic sciences has led to accurate genetic diagnosis and novel effective therapeutic strategies for some diseases. For other diseases, the genetic basis and pathophysiology remain unclear. Further researches are therefore crucial to innovate ways to overcome diagnostic challenges and develop effective treatment options for these orphan diseases.