bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Characterization of Intermediate‐Scale Ionospheric Structure
Authors: Rino Charles , Carrano Charles
Published: October 2018

Characterization of ionospheric structure starts with spectral analysis of one‐dimensional time series. Unknown spectral density function (SDF) parameters are estimated by model‐fitting procedures, which will be referred to in this paper collectively as irregularity parameter estimation. If the diagnostic SDF has a power law form, linear least squares estimation (LLE) can be used to estimate the power law parameters. In this paper simulations are used to investigate LLE estimates of diagnostic single‐component and two‐component power law SDFs. There is a known turbulent strength bias and a more troublesome correlation between the turbulent strength and the spectral index. We found that this intrinsic property of LLE estimators completely explains a similar correlation long observed in both in situ and radio propagation ionospheric diagnostic measurements. Maximum likelihood estimation (MLE) is superior to LLE but requires knowledge of the probability distribution function of the SDF estimator. To this end one can exploit the fact that the probability distribution function of a periodogram about the its true mean is well approximated by a χD distribution. With an hypothesized true mean SDF defined by a small set of parameters, the parameters can be adjusted to maximize the likelihood that the periodogram was generated by the parameterized SDF. Furthermore, algorithms that adjust parameters to maximize likelihood can use functions of the defining parameters being adjusted to improve performance. Recognizing that correlation between turbulent strength and spectral index estimates is an intrinsic measurement property, error minimization is particularly important. A modified MLE procedure is presented that provides robust initiation and good two‐component power law parameter estimates.
An Ensemble Optimization Framework for Coupled Design of Hydropower Contracts and Real‐Time Reservoir Operating Rules
Authors: Sahu Reetik Kumar , McLaughlin Dennis B.
Published: October 2018

Revenues from hydropower generation often depend on the operator's ability to provide firm power in the presence of uncertain inflows. The primary options available for optimizing revenue are negotiation of a firm power contract before operations begin and adjustment of the reservoir release during operations. Contract and release strategy optimization are closely coupled and most appropriately analyzed with stochastic real‐time control methods. Here we use an ensemble‐based approach to stochastic optimization that provides a convenient way to construct nonparametric revenue probability distributions to explore the implications of uncertainty. The firm power contract is a simplified bilateral fixed price agreement that partially insulates operator and buyer from price fluctuations. The release control laws and firm energy target are jointly optimized to maximize the operator's expected revenue. Revenue probability distributions and related spill performance statistics indicate that predictive operating strategies such as stochastic dynamic programming and model predictive control can give significantly better performance than standard deterministic operating rules. The performance obtained from batch optimization with perfect inflow information establishes a convenient upper bound on potential revenue and provides a baseline for assessing the significance of differences between real‐time operating strategies. Sensitivity analysis indicates that the benefits of predictive operational strategies are greatest for reservoirs with medium nondimensional residence times and less important for reservoirs with large residence times. Overall, probabilistic analysis of the coupled hydropower contract‐operations problem provides a realistic way to assess revenue and risk for reservoirs that must provide firm power when inflows are uncertain.
C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event
Authors: Messenger Zachary J. , Hall Jonathan R. , Jima Dereje D. , House John S. , Tam Hann W. , Tokarz Debra A. , Smart Robert C.
Published: October 2018

Therapeutic targeting of specific genetic changes in cancer has proven to be an effective therapy and the concept of synthetic lethality has emerged. CCAAT/enhancer-binding protein-β (C/EBPβ), a basic leucine zipper transcription factor, has important roles in cellular processes including differentiation, inflammation, survival, and energy metabolism. Using a genetically engineered mouse model, we report that the deletion C/EBPβ in pre-existing oncogenic Ha-Ras mouse skin tumors in vivo resulted in rapid tumor regression. Regressing tumors exhibited elevated levels of apoptosis and p53 protein/activity, while adjacent C/EBPβ-deleted skin did not. These results indicate that the deletion of C/EBPβ de-represses p53 in oncogenic Ras tumors but not in normal wild-type Ras keratinocytes, and that C/EBPβ is essential for survival of oncogenic Ras tumors. Co-deletion of C/EBPβ and p53 in oncogenic Ras tumors showed p53 is required for tumor regression and elevated apoptosis. In tumors, loss of a pathway that confers adaptability to a stress phenotype of cancer/tumorigenesis, such as DNA damage, could result in selective tumor cell killing. Our results show that oncogenic Ras tumors display a significant DNA damage/replicative stress phenotype and these tumors have acquired a dependence on C/EBPβ for their survival. RNAseq data analysis of regressing tumors deleted of C/EBPβ indicates a novel interface between p53, type-1 interferon response, and death receptor pathways, which function in concert to produce activation of extrinsic apoptosis pathways. In summary, the deletion of C/EBPβ in oncogenic Ras skin tumors is a synthetic lethal event, making it a promising target for future potential anticancer therapies.
Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel
Authors: Veldkamp Marieke W. , Geuzebroek Guillaume S. C. , Baartscheer Antonius , Verkerk Arie O. , Schumacher Cees A. , Suarez Gedeon G. , Berger Wouter R. , Casini Simona , van Amersfoorth Shirley C. M. , Scholman Koen T. , Driessen Antoine H. G. , Belterman Charly N. W. , van Ginneken Antoni C. G. , de Groot Joris R. , de Bakker Jacques M. T. , Remme Carol Ann , Boukens Bas J. , Coronel Ruben
Published: October 2018

The cardiac autonomic nervous system (ANS) controls normal atrial electrical function. The cardiac ANS produces various neuropeptides, among which the neurokinins, whose actions on atrial electrophysiology are largely unknown. We here demonstrate that the neurokinin substance-P (Sub-P) activates a neurokinin-3 receptor (NK-3R) in rabbit, prolonging action potential (AP) duration through inhibition of a background potassium current. In contrast, ventricular AP duration was unaffected by NK-3R activation. NK-3R stimulation lengthened atrial repolarization in intact rabbit hearts and consequently suppressed arrhythmia duration and occurrence in a rabbit isolated heart model of atrial fibrillation (AF). In human atrial appendages, the phenomenon of NK-3R mediated lengthening of atrial repolarization was also observed. Our findings thus uncover a pathway to selectively modulate atrial AP duration by activation of a hitherto unidentified neurokinin-3 receptor in the membrane of atrial myocytes. NK-3R stimulation may therefore represent an anti-arrhythmic concept to suppress re-entry-based atrial tachyarrhythmias, including AF.
Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS
Authors: Hacker Carolin , Cai Xiaofeng , Kegler Carsten , Zhao Lei , Weickhmann A. Katharina , Wurm Jan Philip , Bode Helge B. , Wöhnert Jens
Published: October 2018

Several peptides in clinical use are derived from non-ribosomal peptide synthetases (NRPS). In these systems multiple NRPS subunits interact with each other in a specific linear order mediated by specific docking domains (DDs), whose structures are not known yet, to synthesize well-defined peptide products. In contrast to classical NRPSs, single-module NRPS subunits responsible for the generation of rhabdopeptide/xenortide-like peptides (RXPs) can act in different order depending on subunit stoichiometry thereby producing peptide libraries. To define the basis for their unusual interaction patterns, we determine the structures of all N-terminal DDs (NDDs) as well as of an NDD-CDD complex and characterize all putative DD interactions thermodynamically for such a system. Key amino acid residues for DD interactions are identified that upon their exchange change the DD affinity and result in predictable changes in peptide production. Recognition rules for DD interactions are identified that also operate in other megasynthase complexes.
Mutational interactions define novel cancer subgroups
Authors: Kuipers Jack , Thurnherr Thomas , Moffa Giusi , Suter Polina , Behr Jonas , Goosen Ryan , Christofori Gerhard , Beerenwinkel Niko
Published: October 2018

Large-scale genomic data highlight the complexity and diversity of the molecular changes that drive cancer progression. Statistical analysis of cancer data from different tissues can guide drug repositioning as well as the design of targeted treatments. Here, we develop an improved Bayesian network model for tumour mutational profiles and apply it to 8198 patient samples across 22 cancer types from TCGA. For each cancer type, we identify the interactions between mutated genes, capturing signatures beyond mere mutational frequencies. When comparing mutation networks, we find genes which interact both within and across cancer types. To detach cancer classification from the tissue type we perform de novo clustering of the pancancer mutational profiles based on the Bayesian network models. We find 22 novel clusters which significantly improve survival prediction beyond clinical information. The models highlight key gene interactions for each cluster potentially allowing genomic stratification for clinical trials and identifying drug targets.
Author Correction: Active Printed Materials for Complex Self-Evolving Deformations
Authors: Raviv Dan , Zhao Wei , McKnelly Carrie , Papadopoulou Athina , Kadambi Achuta , Shi Boxin , Hirsch Shai , Dikovsky Daniel , Zyracki Michael , Olguin Carlos , Raskar Ramesh , Tibbits Skylar
Published: October 2018

A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has not been fixed in the paper
Engaging cervical spinal circuitry with non-invasive spinal stimulation and buspirone to restore hand function in chronic motor complete patients
Authors: Freyvert Yevgeniy , Yong Nicholas Au , Morikawa Erika , Zdunowski Sharon , Sarino Melanie E. , Gerasimenko Yury , Edgerton V. Reggie , Lu Daniel C.
Published: October 2018

The combined effects of cervical electrical stimulation alone or in combination with the monoaminergic agonist buspirone on upper limb motor function were determined in six subjects with motor complete (AIS B) injury at C5 or above and more than one year from time of injury. Voluntary upper limb function was evaluated through measures of controlled hand contraction, handgrip force production, dexterity measures, and validated clinical assessment batteries. Repeated measure analysis of variance was used to evaluate functional metrics, EMG amplitude, and changes in mean grip strength. In aggregate, mean hand strength increased by greater than 300% with transcutaneous electrical stimulation and buspirone while a corresponding clinically significant improvement was observed in upper extremity motor scores and the action research arm test. Some functional improvements persisted for an extended period after the study interventions were discontinued. We demonstrate that, with these novel interventions, cervical spinal circuitry can be neuromodulated to improve volitional control of hand function in tetraplegic subjects. The potential impact of these findings on individuals with upper limb paralysis could be dramatic functionally, psychologically, and economically.
Host lipid sensing promotes invasion of cells with pathogenic Salmonella
Authors: Shivcharan Sonia , Yadav Jitender , Qadri Ayub
Published: October 2018

PathogenicSalmonellaspecies initiate infection by invading non-phagocytic intestinal epithelial cells (IEC). This invasion is brought about by a number ofSalmonellainvasion promoting molecules (Sips) encoded by theSalmonellaPathogenicity Island - 1 (SPI-1). Intracellular delivery of some of these molecules also brings about caspase-1 – mediated pyroptotic cell death that contributes to pathogen clearance. These molecules are secreted and delivered inside cells upon contact ofSalmonellawith one or more host signals whose identity has not been established. We show that lysophosphatidylcholine (LPC) released following activation of caspase-1 inSalmonella– infected cells and abundant in plasma amplifies production of Sips from this pathogen and promotes its cellular invasion. LPC brings about adenylate cyclase and cAMP receptor protein (CRP) - dependentde novosynthesis of SipC that is accompanied by its translocation to bacterial cell surface and release into the outside milieu. Treatment ofSalmonellawith LPC produces sustained induction of SPI - 1 transcriptional regulator, hilA. Our findings reveal a novel host lipid sensing - driven regulatory mechanism forSalmonellainvasion.
In-depth study on resonant tunneling for subwavelength imaging
Authors: Anzan-Uz-Zaman Md. , Song Kyungjun , Lee EunJoong , Hur Shin
Published: October 2018

We report new frequency bands for subwavelength imaging by using the resonant tunneling method which have not been explored previously. As per the existing theory of resonant tunneling, imaging frequency is limited for a certain number of crystals. However, after conducting an analytical analysis over a wide range of frequencies, we observed that higher frequencies do exist for subwavelength imaging. We verified this observation both numerically and experimentally. We extended our study to observe the effect of lattice periodicity on image resolution. By reducing periodicity during experiment, we achieved a resolution of λ/9.5 at the conventional region and λ/2.45 at the higher band region.
Tregitope-linked Refined Allergen Vaccines for Immunotherapy in Cockroach Allergy
Authors: Prangtaworn Pannathee , Chaisri Urai , Seesuay Watee , Mahasongkram Kodchakorn , Onlamoon Nattawat , Reamtong Onrapak , Tungtrongchitr Anchalee , Indrawattana Nitaya , Chaicumpa Wanpen , Sookrung Nitat
Published: October 2018

Allergen-specific immunotherapy (AIT) facilitates long-term resolution of allergic morbidity resulting in reduced drug use and increased refractoriness to new sensitization. AIT effectiveness has been demonstrated in seasonal and perennial allergies, and insect stings. However, data and studies in AIT relative to cockroach (CR) allergy are relatively scarce. In this study, mice allergic to American CR (Periplaneta americana) were treated with a liposome (L)-entrapped vaccine made of mouse Tregitope289-Per a 9 of the CR, Tregitope167-Per a 9, or Per a 9 alone – or placebo. Allergic mice that received an individual vaccine intranasally had reduced Th2 response, reduced lung inflammation, and reduced respiratory tissue remodeling. However, only L-Tregitope289-Per a 9 and L-Tregitope167-Per a 9 induced expression of immunosuppressive cytokine genes (IL-10,TGF-β, andIL-35for L-Tregitope289-Per a 9, andIL-10andTGF-βfor L-Tregitope167-Per a 9) and increment of idoleamine-2,3-dioxygenase 1 (IDO1), indicating that these vaccines caused allergic disease suppression and reversal of respiratory tissue remodeling via generation of regulatory lymphocytes. Liposome entrapped-recombinant Per a 9 (L-Per a 9) did not cause upregulation of immunosuppressive cytokine genes and IDO1 increment; rather, L-Per a 9 induced high expression ofIFN-γin lungs of treated mice, which resulted in mitigation of allergic manifestations. This study provides compelling evidence that both liposome-entrapped vaccines made of single refined major allergen alone and single refined major allergen linked with Tregitopes are effective for reducing allergen-mediated respiratory tissue inflammation and remodeling, but through different mechanisms.
Synergistic and independent action of endogenous microRNAs 122a and 199a for post-transcriptional liver detargeting of gene vectors
Authors: Dhungel Bijay , Ramlogan-Steel Charmaine A. , Steel Jason C.
Published: October 2018

In hepatocellular carcinoma (HCC), which usually develops in a cirrhotic liver, treatments preserving normal liver function and viability are vitally important. Here, we utilise the differential expression of miRNAs 122a and 199a between normal hepatocytes and HCC to generate vectors harbouring their binding sites for hepatocyte detargeting. Using a reporter gene, we observed a synergistic detargeting of cells expressing both miRNAs as well as cells expressing either of the miRNAs; while expression was retained in HCC cells negative for both miRNA122a and miRNA199a. Mimics and inhibitors for individual miRNAs were used to confirm these results. Furthermore, suicide gene therapy with cytosine deaminase (CD)/5-fluorocytosine system resulted in limited killing of cells expressing either of the two miRNAs. Finally, we report feasibility of using adeno associated virus (AAV) based vectors for delivery of this dual regulated gene delivery system. These results present a novel dual targeted system whereby miRNA122a and miRNA199a act either synergistically or independently in regulating transgene expression with vectors harbouring binding sites of both miRNAs and have implications in detargeting vectors from multiple cell types in the liver.
Carnivory in the larvae of Drosophila melanogaster and other Drosophila species
Authors: Yang Daxiang
Published: October 2018

Drosophila melanogaster is widely used as a model organism for biological investigations, and food is a major aspect of its ecology and evolutionary biology. Previous studies have shown that this insect can use fruits, yeasts and insect carcasses as its food sources. In this study, we demonstrate that this species is an omnivore, that its larvae can exploit not only fruits and yeast but also foods of animal origin (FAOs), and that larvae consume adult carcasses regularly. FAO-fed larvae develop into adulthood within a normal developmental time frame without the help of microbes. Yeast foods are better for Drosophila development than are foods of plant origin (FPOs) or FAO because in yeast foods, more eggs complete their life cycle, and the body size of emerged flies is much greater. Flies can use a mixture of yeast-FAO, which significantly boosts female fertility. Larvae digest FAOs externally. Larval D. virilis, D. hydei, and D. simulans are also omnivorous and demonstrate the same feeding habits as larval D. melanogaster. These findings prompt us to reconsider previous conclusions about the original adaptations of D. melanogaster and other Drosophila species and have direct implications for diet-related studies using Drosophila as a model organism.
Coating two-dimensional MoS2 with polymer creates a corrosive non-uniform interface
Authors: Thi Quoc Huy , Kim Hyun , Zhao Jiong , Ly Thuc Hue
Published: October 2018

Two-dimensional (2D) materials and soft materials are both susceptible to mechanical instabilities, such as buckling, wrinkling, folding and creasing, especially when located on surfaces. Here, we report that weak van der Waals interactions cause the interface between 2D molybdenum disulphide (MoS2) and a soft poly(methyl methacrylate) coating to demonstrate mechanical instability and delamination. The resulting non-uniform and buckled interface greatly hampers the ability of the coating to protect the MoS2 substrate. Also, the corrosion rate of 2D MoS2 and quench rate of intrinsic luminescence in 2D MoS2 were significantly accelerated by the soft coating. Owing to the formation of corrosive cavities at the interface, the geometry and size of the flakes became the dominating factor, and a critical size of 2D flakes for such interfacial instability was determined based on elasticity theory. Such hazardous corrosion in a 2D material caused by a soft coating raises concern for their use in electronic packaging, and for the processing of van der Waals-layered materials for future applications.
Solvent-promoted catalyst-free regioselective N-incorporation multicomponent domino reaction: rapid assembly of π-functionalized [60]fullerene-fused dihydrocarbolines
Authors: Liu Tong-Xin , Yue Shuaishuai , Wei Changgeng , Ma Nana , Zhang Pengling , Liu Qingfeng , Zhang Guisheng
Published: October 2018

An unprecedented solvent-promoted N-incorporation multicomponent domino chemistry was developed for the direct construction of π-functionalized [60]fullerene-fused dihydrocarbolines from simple hydrocarbons.
Exploring polymorphism and stoichiometric diversity in naproxen/proline cocrystals
Authors: Tumanova Natalia , Tumanov Nikolay , Fischer Franziska , Morelle Fabrice , Ban Voraksmy , Robeyns Koen , Filinchuk Yaroslav , Wouters Johan , Emmerling Franziska , Leyssens Tom
Published: October 2018

This work studies a multitude of cocrystals obtained by combining chiral and/or racemic naproxen and proline, 17 in total.
Magnetostructural relationships in polymorphic ethylmalonate-containing copper(ii) coordination polymers
Authors: Pasán Jorge , Sanchiz Joaquín , Lloret Francesc , Julve Miguel , Ruiz-Pérez Catalina
Published: October 2018

Three ethylmalonate-containing non-centrosymmetric copper(ii) coordination polymers with magnetic properties ranging from antiferromagnetism to ferromagnetic ordering are synthetized under nearly identical conditions.
Debye screening, overscreening and specific adsorption in solutions of organic ions
Authors: Bresme Fernando , Robotham Oliver , Chio Weng-I Katherine , Gonzalez Miguel Angel , Kornyshev Alexei
Published: October 2018

We resolve using atomistic simulations the ions correlations, clustering and charge screening effects or organic electrolytes in dichloroethane.
Crystallinity-dependent capacity of a LiBC anode material in Li-ion batteries
Authors: Jia Jianfeng , Chen Shaorui , Yang Qianwen , Feng Xiang , Li De
Published: October 2018

The crystal structure of LiBC evolves dramatically during the charge and discharge processes, which depend on LiBC crystallinity.
Determining the lipid specificity of insoluble protein transmembrane domains
Authors: Ziblat R. , Weaver J. C. , Arriaga L. R. , Chong S. , Weitz D. A.
Published: October 2018

Overcoming solubility of membrane protein transmembrane domains to study their specificity to lipid compositions.
Rapid detection of multiple respiratory viruses based on microfluidic isothermal amplification and a real-time colorimetric method
Authors: Wang Ruili , Zhao Rongtao , Li Yang , Kong Wen , Guo Xudong , Yang Yi , Wu Feng , Liu Wanying , Song Hongbin , Hao Rongzhang
Published: October 2018

We developed a real-time colorimetric method based on LAMP-integrated microfluidic chip system for diagnosing multiple respiratory viruses.
Designed fabrication of three-dimensional δ-MnO2-cladded CuCo2O4 composites as an outstanding supercapacitor electrode material
Authors: Pang Mingjun , Jiang Shang , Zhao Jianguo , Zhang Sufang , Liu Rui , Qu Wenshan , Pan Qiliang , Xing Baoyan , Gu Ling , Wang Haiqing
Published: October 2018

Three-dimensional δ-MnO2-cladded CuCo2O4 composites on Ni foam have been designed via a hydrothermal method followed by one-pot chelation-mediated aqueous processes.
High thermal stability of the Ru–ON (MS1) linkage isomer of the ruthenium nitrosyl complex [RuNO(Py)4F](ClO4)2 with the trans NO–Ru–F coordinate
Authors: Kostin Gennadiy A. , Mikhailov Artem A. , Kuratieva Natalia V. , Pishchur Denis P. , Makhinya Alexander N.
Published: October 2018

The [RuNO(Py)4F](ClO4)2 complex with the highest thermal stability of the Ru–ON linkage isomer.
The regulation of hydroboration of olefins by oriented external electric field
Authors: Zhang Mingxia , Zhang Fengyi , Xu Hongliang , Su Zhongmin
Published: October 2018

By employing an oriented external electric field as a catalyst or inhibitor, the model reactions of the hydroboration of terminal olefins with the simplest borane were studied for the first time.
3D Ti3C2Txaerogels with enhanced surface area for high performance supercapacitors
Authors: Wang Xinyu , Fu Qishan , Wen Jing , Ma Xinzhi , Zhu Chuncheng , Zhang Xitian , Qi Dianpeng
Published: October 2018

An ultra-light porous 3D Ti3C2Txaerogel electrode was prepared by freeze-drying the wet hydrogel, which has an ultrahigh rate capability and excellent cycling life.
Solution-phase synthesized iron telluride nanostructures with controllable thermally triggered p-type to n-type transition
Authors: Zheng Wei , Hong Sungbum , Min Bokki , Wu Yue
Published: October 2018

We report the solution-phase synthesis of iron telluride with controllable reversible switching behavior between p- and n-type conduction.
Organic core–shell-shaped micro/nanoparticles from twisted macrocycles in Schiff base reaction
Authors: Chen Huaiyu , Huang Chao , Ding Yazhou , Zhang Qi-Long , Zhu Bi-Xue , Ni Xin-Long
Published: October 2018

A series of organic core–shell-shaped micro/nanoparticles from twisted enantiomeric macrocycles could be obtained in Schiff base reaction with high yield at room temperature.
HDAC1 overexpression enhances β-cell proliferation by down-regulating Cdkn1b/p27
Authors: Draney Carrie , Austin Matthew C. , Leifer Aaron H. , Smith Courtney J. , Kener Kyle B. , Aitken Talon J. , Hess Kavan H. , Haines Amanda C. , Lett Elle , Hernandez-Carretero Angelina , Fueger Patrick T. , Arlotto Michelle , Tessem Jeffery S.
Published: October 2018

The homeobox transcription factor Nkx6.1 is sufficient to increase functional β-cell mass, where functional β-cell mass refers to the combination of β-cell proliferation, glucose-stimulated insulin secretion (GSIS) and β-cell survival. Here, we demonstrate that the histone deacetylase 1 (HDAC1), which is an early target of Nkx6.1, is sufficient to increase functional β-cell mass. We show that HDAC activity is necessary for Nkx6.1-mediated proliferation, and that HDAC1 is sufficient to increase β-cell proliferation in primary rat islets and the INS-1 832/13 β-cell line. The increase in HDAC1-mediated proliferation occurs while maintaining GSIS and increasing β-cell survival in response to apoptotic stimuli. We demonstrate that HDAC1 overexpression results in decreased expression of the cell cycle inhibitor Cdkn1b/p27 which is essential for inhibiting the G1 to S phase transition of the cell cycle. This corresponds with increased expression of key cell cycle activators, such as Cyclin A2, Cyclin B1 and E2F1, which are activated by activation of the Cdk4/Cdk6/Cyclin D holoenzymes due to down-regulation of Cdkn1b/p27. Finally, we demonstrate that overexpression of Cdkn1b/p27 inhibits HDAC1-mediated β-cell proliferation. Our data suggest that HDAC1 is critical for the Nkx6.1-mediated pathway that enhances functional β-cell mass.
MIB1 mutations reduce Notch signaling activation and contribute to congenital heart disease
Authors: Li Binbin , Yu Liwei , Liu Dong , Yang Xueyan , Zheng Yufang , Gui Yonghao , Wang Hongyan
Published: October 2018

Congenital heart disease (CHD) is one of the most common birth defects in humans, but its genetic etiology remains largely unknown despite decades of research. The Notch signaling pathway plays critical roles in embryonic cardiogenesis. Mind bomb 1 (Mib1) is a vital protein that activates the Notch signaling pathway through promoting ubiquitination, endocytosis and subsequent activation of Notch ligands. Previous studies show that Mib1 knockout in mice completely abolishes Notch signaling, leading to cardiac deformity. However, the function of MIB1 and its potential disease-causing mutations are poorly studied in human CHD. In this research, we identified four novel non-synonymous heterozygous rare mutations of MIB1 from 417 Han Chinese CHD patients. The following biochemical analyses revealed that mutations p.T312K fs*55 and p.W271G significantly deplete MIB1’s function, resulting in a lower level of JAGGED1 (JAG1) ubiquitination and Notch signaling induction. Our results suggest that pathologic variants in MIB1 may contribute to CHD occurrence, shedding new light on the genetic mechanism of CHD in the context of the Notch signaling pathway.
Cements of low water demand is the flagship of composite low clinker cement binders in Russia and abroad
Authors: Makarenko Sergey , Khokhryakov Oleg , Kashaev Eduard , Khozin Vadim
Published: October 2018

The paper provides research results on obtaining a compositional CLWD with the use of ashes from the Novo-Irkutsk Thermal Power Station and magnesites of the Savinsk deposit of the Irkutsk area. The aim of the research is to develop an effective ecological technology for producing high-quality cements. As a result of the research, the technological and physical-mechanical properties of the cement paste and cement stone were determined. The cement ND changes depending on the composition (12 to 19%), while the cement stone’s strength varies from 49.5 MPa to 77.7 MPa. The CLWD strength (of different grades according to GOST 310.4) is estimated in 1 day, 28 days, and after steaming. A comparison with ordinary Portland cement was made. It is established that the CLWD 50 (has 50% of fillers) is not inferior in its physico-mechanical properties to ordinary Portland cement. A regression analysis of the influence of a number of factors on the strength of CLWD at three time periods (1 day, 28 days, and after steaming) was carried out. The regression equation was also obtained.
Innovative methods of extracting the loose gold from technogenic deposits in the Irkutsk region
Authors: Golovina Elena , Dykusova Anastasia , Zhizhelev Maxim
Published: October 2018

In Russia and abroad, the scope of the use of gold has significantly expanded, which undoubtedly affected the level of production. However, despite the fairly high rates of gold mining, the economic situation that has developed in recent years makes the companies look for new innovative placer processing technologies that will allow preserving and increasing the extraction of the precious metals. The search for and exploration of new placer gold deposits requires very considerable financial resources and time, and therefore the proposed project for the extraction of alluvial gold from technogenic deposits is of great importance for the functioning of the mining industry of the Irkutsk region, since it helps to overcome at least two negative trends: firstly, the deterioration of the mineral resource base, and secondly, large losses of gold with dump products (up to 50%) associated with the use of obsolete washing equipment. Modernization of production capacities and processing technologies is not only one of the main factors for increasing competitiveness in the gold mining industry and attracting investors, but will also help increasing the mineral resource base of the Irkutsk region by reassessing technogenic deposits, setting gold technogenic deposits on the balance, development of technologies for technogenic deposits and processing, and involvement of technogenic deposits in the mass processing.
Improvement of operation modes of water treatment systems using baromembrane technologies
Authors: Samarkina Ekaterina , Gudzenko Anna , Bondarenko Svetlana , Samarkina Anastasia
Published: October 2018

The paper touches upon the issues connected with the solutions of the problems arising at operation of membrane installations for water preparation, in particular high water consumption for own needs. The reasons leading to their occurrence are analyzed in the article. A comparison of the performance of membrane systems against the calculated values is made. The influence of aging of membranes on water consumption for own needs is studied. The tests of a membrane element have been carried out on a laboratory installation, the results of which are used for the analysis of the chemical contamination. The options of solving the identified problems are proposed.
Probabilistic analysis of the strength and reliability of reinforced concrete structures under low-temperature impact
Authors: Pinus Boris , Pinus Zhanetta
Published: October 2018

The paper presents the results of numerical modeling of the kinetics of strength and reliability of bent reinforced concrete elements in the process of cyclic low-temperature and humidity effects of various levels. In this case, the calculated strength model is adopted in accordance with the normative functional dependencies, taking into account the random nature of the implementation of the input parameters, while the reliability model is in the form of a safety factor determined by the statistical parameters of their distributions. The latter are taken on the basis of representative empirical data of changes in the strength and deformation of concrete and reinforcement (in concrete) at certain stages of depletion of the standard resource of frost resistance. Substantial differences are established in the change in the strength and reliability parameters for the FTC and the determining effect of the reinforcement level on their kinetics.
Hydraulic optimization of the flat solar collectors SUN 1 and the temperature gradient of the heat carrier in a system of connected solar units
Authors: Tunik Alexander , Tolstoy Mikhail
Published: October 2018

The article presents an analytical method for selecting the optimal technical performance of the heat exchanger for a flat solar collector, using meander-shaped heat-sensing tubes, which allow obtaining a higher value of the coolant temperature at the exit from the flat solar collector. Also, the article presents a technique for determining the temperature of the coolant at the exit from a flat solar collector and the possibility of its application in the design of solar heating systems. This technique will allow to determine the optimum and the maximum possible number of successively connected flat liquid helium collectors and, accordingly, to obtain effective design and technical solutions. The technique is based on the use of the empirical dependence of the coolant’s temperature in the outlet branch pipe of a flat solar collector on the length of its heat-sensing tubes. The technique has been successfully applied in the study of heat-mass transfer processes in a new model of a flat solar collector being developed at the Department of Engineering Communications and Life Support Systems of the Irkutsk National Research Technical University. A comparative analysis of the measured values of the coolant temperature in the outlet branch pipe of the investigated reservoir with the values calculated using the empirical dependence presented in the article actually confirmed the adequacy of the presented technique with reference to one solar collector. The article shows results of calculating a system of consecutively connected collectors, which was conducted using the aforementioned technology.
Treatment and utilization of liquid communal waste in the cities
Authors: Vialkova Elena , Zemlyanova Marina , Fugaeva Anastasia
Published: October 2018

Treatment and further utilization of wastewater sludge are the important city service problem. The paper presents an efficient method of super high frequency irradiation for communal liquid waste such as wastewater sludge. The effect of microwaves on the properties of sediments, including the outlet of heavy metal ions in to water, is shown. Technical and economic indexes and results of experimental researches, indicating the opportunities of microwave irradiation in processes of sediments heating, are presented. The influence on sludge temperature of some technological SHF parameters has been studied. Because of statistic analyze, a regression polynomial equation describing the heating of sludge mixture has been obtained. The microwave and electro thermal processing of municipal liquid waste taken from a city’s wastewater plants have been compared. Energy efficient economy of microwave irradiation using for municipal wastewater sediments have been confirmed.
The three-dimensional lattice as an architectural space
Authors: Bolshakov Andrey
Published: October 2018

Space is the main material with which the architect works. The space organized by the means of architecture is an art environment for the life of society. With many aspects of the organization of space, which are studied in the literature, the problem of their assembly and integration remains unsolved. The paper proposes a method of assembling spatial representations in architecture-the correlation of the spatial lattice and the factors of its form-formation, considered in the system, i.e. together. The approach is that in a broad overview of the world architecture, both in its theory and in practice, from historical to modern, examples of modification of spatial grids under the influence of one or a group of dominant factors are revealed. As a result, provisions on the relationship of the geometry of spatial grids with the following factors have been revealed: publicity and privacy; architectonics, the influence of the lattice on the differentiation of the streams of human movement; the architecture’s ability to carry a message; navigation properties, evaluation of connectivity and centrality of places in the spatial lattice; evaluation of the quality of the composition through the identification of ways of order and randomness in the elements of the spatial lattice. The results of the work can be used both for theoretical understanding of the architectural space in the study and design of architecture, and in architectural education.
Large-panel buildings of the series 1-335: economics, ecology, and social aspect
Authors: Petrov Alexander , Matveeva Maria , Petunin Alexander
Published: October 2018

To solve the housing problem is one the most important task of the social and economic development of the regions and of Russia as a whole. One of the aspects of the problem is the large amount of old and dilapidated housing that has accumulated over the previous years. The paper contains data on the state of the housing stock of the Irkutsk region for 2000-2016. The structure of the housing stock has been analyzed. By the present time, the normatively established service life and technical resource of the wall load-bearing and enclosing structures of large-panel buildings of the series 1-335 of the construction of 1960s – 1970s have been exhausted. Specialists came to the common conclusion on this issue.
The building complex of the region in the aspect of implementing the main directions of the Strategy for the Development of the Housing Sector
Authors: Peshkov Vitaly
Published: October 2018

The priority task of the social and economic development of the Russian Federation is providing the population with housing. The strategy for the Development of the Housing Sector in the Russian Federation for the period until 2025 is aimed at improving the living conditions of the population. As follows from this Strategy, “Each family must be able to improve its housing conditions in various ways.” Considering the urban environment, the Strategy assumes that “the transition from the construction of square meters to housing in a comfortable urban environment” and “the development and implementation of standards for the integrated development of territories.” The article systemically analyzes the basic directions of improving various aspects of building houses in the city environment in the aspect of increasing the demand and offer of the finished building products. The rating of the Irkutsk developers is made on the volume of housing introduced in 2016, as well as the mission, the company’s strategy, and the strategies of its subdivisions. The corresponding conclusions are also made.
Brownfield (re)development: new perspectives for Zaton in Irkutsk
Authors: Engel Barbara , Valery Kozlov
Published: October 2018

(Re)development of Brownfields is nowadays a challenging task for growing cities since they represent valuable ressources for their future development – such as in Irkutsk. Therefor the development of peninsula Zaton is a responsibly issue not only concerning the sustainable development of the territory itself, but as well of the whole city. The article explains the tasks and problems of the 19th session of Baikal Winteruniversity and reviews the results.
Priorities of social and economic safety
Authors: Nechaev Vasiliy , Mikhailushkin Pavel , Presnyakov Denis
Published: October 2018

The purpose is to consider the main theoretical approaches to definition of social safety and estimate its conditions. The analysis of economic indicators of 2016-2017 has shown that with a growth of the key economic indicators, negative dynamics of the real located income of the population still remain. In the article, the importance of social and economic safety is emphasized. The two main conditions of economic safety provide the presence of the influential middle class and a ratio between the minimum and maximum income of the population. By means of Lorentz’s curve, the increase of stratification of the population on income is shown. The article concludes that that poverty is a threat of economic security, because it slows down economic growth. The authors also assess the influence of administrative impact on social and economic development of regions, finding a weak reliance.
Theoretical basis of the spatial development of rest at Lake Baikal
Authors: Valery Khromeshkin , Valery Kozlov
Published: October 2018

In persisting work theoretical questions existence, social structure and valuables of the rest are considered as reflection material and spiritual essence to vital activity of the person. The Brought forth idea to modernizations of the beliefs about dug the rest of the person in modern natural history on base of the theories of the rest. The Presented results of the development basis to theories of the rest. In scientific terminology are incorporated new notions to theories of the rest: rest, social structure of the rest, history of the development of the rest in Terrestrial civilization, value of the rest, lieves rest and others. On base ценностного approach are offered general concepts real, ideal and equitable rest.
Innovative and investment development of vegetable growing
Authors: Razin Anatoliy , Taktarova Svetlana , Semenov Vladimir
Published: October 2018

The purpose of the study is to examine the features of innovative and investment development of vegetable growing. It is substantiated that innovative and investment activities are interrelated, their balanced combination is necessary for further development of the vegetable growing industry. Organizations that produce vegetables have been ranked. A conclusion is made about the need for innovative and investment development of the industry. The organizational and economic mechanism of the innovative and investment development of the industry is proposed, involving the use of public-private partnership, the involvement of industry associations and unions, the introduction of sectoral marketing, bringing the education system in line with the requirements of the innovation economy, the formation of clusters, the deepening of the specialization of organizations within the spatial organization of the country, and the development of infrastructure facilities. Basic innovations for introduction in vegetable growing are considered.
To the question of planning the volume of investments for capital repair of the common property in the apartment buildings in the Irkutsk region
Authors: Dedukhina Ekaterina , Torgashina Irina
Published: October 2018

The regional program of capital repair of the common property in multi-apartment buildings located on the territory of the Irkutsk region is analyzed in this paper. The drawbacks of the program are described. Particular attention has been paid to the identification of dependence of the residential buildings characteristics and the cost of capital repairs. Proposals have been made to improve the mechanism for financing capital repair of the common property in the apartment buildings.
Developing a model of effective growth for small and medium business for sparsely populated and remote areas within the framework of the green economy concept (based on the example of the Irkutsk region)
Authors: Mashovich Andrei , Ruposov Vytaliy , Moskvitin Vladimir
Published: October 2018

The paper addresses the results of research in the field of creation of new "green" technologies and their economic validity. The authors argue that the trend of the remote territories’ development should become the basis of the effectiveness of introduction of these technologies. Economic disproportions in the development of such territories have led to the creation of technologies that allow using local resources. As a result of the research, a model for the development of the depressed areas through the creation of effective growth points using the opportunities of small and medium entrepreneurship has been elaborated.
Using global environment trends for adaptating the higher education to changes and increasing the investment attractiveness of the region
Authors: Kaluzhnova Nadezhda , Ogarkova Elena , Osipov Mikhail
Published: October 2018

The work is devoted to the analysis of the possibilities of adaptation of the Russian system of higher education to changing global environment. The main trends of these changes are singled out and characterized. The results of a sociological study of the correspondence of the existing organizational structures of higher education institutions to the needs of students and the requirements of the time are presented. Measures to improve the system of university training with the aim of forming a modern and adaptive organizational structure are proposed in the paper.
Effective dispute settlement as a mechanism of economic attractiveness
Authors: Zaitseva Larisa
Published: October 2018

Commercial disputes the number of which is growing every year can cause economic imbalance if a country doesn’t obtain ADR (Alternative disputes resolution) technologies and methods implementation experience. In the Russian Federation separate branch of courts – state arbitration courts – is established and it demonstrates high quality of litigation. But effective functioning of judiciary (its accessibility, low costs and rapid procedures) doesn’t signify universal character of litigation, especially in the field of investment and construction projects dealing with socially significant objects such as apartment complexes or infrastructure facilities. Within one project different controversies and misunderstandings can arise which should be resolved without delays, abuse of rights and termination of collaboration. The article is focused on three main aspects, defining approaches to ADR promotion: features of legal and judicial system of a concrete state, availability of elaborate measures ensuring ADR successful development, specifics of practice area. Certain means and technologies of ADR are proposed in order to eliminate infringement of construction process participants’ rights. Analysis of state arbitration courts statistics has shown a very low level of ADR implementation. Legislative and explanatory measures fail to cope with this problem. In this connection concrete organizational and educational measures are suggested to enhance the process of ADR promotion for ensuring economic attractiveness.