bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatiotemporal dissection of the cell cycle with single-cell proteogenomics
Authors: Mahdessian Diana , Cesnik Anthony J. , Gnann Christian , Danielsson Frida , Stenström Lovisa , Arif Muhammad , Zhang Cheng , Shutten Rutger , Bäckström Anna , Thul Peter , Cho Nathan H. , Carja Oana , Uhlén Mathias , Mardinoglu Adil , Stadler Charlotte , Lindskog Cecilia , Ayoglu Burcu , Leonetti Manuel D. , Pontén Fredrik , Sullivan Devin , Lundberg Emma
Published: February 2019

Cellular division is a fundamental source of cell-to-cell variability, and studies of transcript and protein abundances have revealed several hundred genes that are regulated by the cell cycle1–8. However, none of these studies provide single-cell resolution of protein expression, leaving an incomplete understanding of cell-to-cell heterogeneity and the roles of cycling transcripts and proteins. Here, we present the first comprehensive map of spatiotemporal heterogeneity of the human proteome by integrating proteomics at subcellular resolution, single-cell transcriptomics, and pseudotime measurements of individual cells within the cell cycle. We identify that 17% of the human proteome displays cell-to-cell variability, of which 26% is correlated to cell cycle progression, and we present the first evidence of cell cycle association for 235 proteins. Only 15% of proteomic cell cycle regulation is due to transcriptomic cycling, which points to other means of regulation such as post-translational modifications. For proteins regulated at the transcript level, we observe a 7.7 hour delay between peak expression of transcript and protein on average. This spatially resolved proteomic map of the cell cycle has been integrated into the Human Protein Atlas and serves as a valuable resource for accelerating molecular studies of the human cell cycle and cell proliferation.
Evosep One Enables Robust Quantitative Deep Proteome Coverage using Tandem Mass Tags while Significantly Reducing Instrument Time
Authors: Krieger Jonathan R. , Wybenga-Groot Leanne E. , Tong Jiefei , Bache Nicolai , Tsao Ming S. , Moran Michael F.
Published: February 2019

The balance between comprehensively analyzing the proteome and using valuable mass spectrometry time is a genuine challenge in the field of proteomics. Multidimensional fractionation strategies have significantly increased proteome coverage, but often at the cost of increased mass analysis time, despite advances in mass spectrometer acquisition rates. Recently, the Evosep One liquid chromatography system was shown to analyze peptide samples in a high throughput manner without sacrificing in depth proteomics coverage. We demonstrate incorporation of Evosep One technology into our multiplexing workflow for quantitative analysis of tandem mass tag (TMT)-labeled non-small cell lung carcinoma (NSCLC) patient-derived xenografts (PDXs). Using a 30 samples per day Evosep workflow, >12,000 proteins were identified in 48 hours of mass spectrometry time, which is comparable to the number of proteins identified by our conventional concatenated EASY-nLC workflow in 67.5 hours. Shorter Evosep gradient lengths reduced the number of protein identifications by 10%, while decreasing mass analysis time by 50%. Thus, our Evosep workflow enables quantitative analysis of multiplexed samples in less time without conceding depth of proteome coverage.
Investigating the effectiveness of school health services delivered by a health provider: a systematic review of systematic reviews
Authors: Levinson Julia , Kohl Kid , Baltag Valentina , Ross David
Published: February 2019

Schools are the only institution regularly reaching the majority of school-age children and adolescents across the globe. Although at least 102 countries have school health services, there is no rigorous, evidence-based guidance on which school health services are effective and should be implemented in schools. To investigate the effectiveness of school health services for improving the health of school-age children and adolescents, a systematic review of systematic reviews (overview) was conducted. Five databases were searched through June 2018. Systematic reviews of intervention studies that evaluated school-based or school-linked health services delivered by a health provider were included. Review quality was assessed using a modified Ballard and Montgomery four-item checklist. 1654 references were screened and 20 systematic reviews containing 270 primary studies were assessed narratively. Interventions with evidence for effectiveness addressed autism, depression, anxiety, obesity, dental caries, visual acuity, asthma, and sleep. No review evaluated the effectiveness of a multi-component school health services intervention addressing multiple health areas. Strongest evidence supports implementation of anxiety prevention programs, indicated asthma education, and vision screening with provision of free spectacles. Additional systematic reviews are needed that analyze the effectiveness of comprehensive school health services, and specific services for under-researched health areas relevant for this population.
Expectancy disconfirmation
Authors: Au Alan Kai Ming , Tse Alan Ching Biu
Published: February 2019

Purpose

The purpose of this paper is to examine the effect of expectancy disconfirmation on passengers’ reactions to airline delays.

Design/methodology/approach

The study uses a between-subject factorial design with 9 treatments involving 161 subjects to collect data to test the hypotheses.

Findings

The study showed that, when given a positive disconfirmation, subjects feel better and are more satisfied, but when given a negative disconfirmation, they feel more negative and dissatisfied. Also, the effect size of positive disconfirmation on satisfaction and feelings about the service provider were significantly less than that of negative disconfirmation of the same size. Hence, in the event of a delay, managers may have to announce the upper bound of the delay duration so that passengers might feel better and become more satisfied when the actual delay duration is shorter than what was initially expected. In addition, they must try their best not to create situations of negative disconfirmation in light of their disproportional impact on satisfaction.

Practical implications

According to the results, airline managers should estimate as accurately as possible the duration of a delay when there is one.

Originality/value

A major contribution of this study is that manipulating the way delay duration information is given to passengers can affect feelings about the delay and the level of satisfaction with the airline.
The resilience of collective bargaining – a renewed logic for joint regulation?
Authors: Moore Sian , Onaran Ozlem , Guschanski Alexander , Antunes Bethania , Symon Graham
Published: February 2019

Purpose

The purpose of this paper is twofold: first, to reassert the persistent association of the decline in collective bargaining with the increase in income inequality, the fall in the share of wages in national income and deterioration in macroeconomic performance in the UK; and second, to present case studies affirming concrete outcomes of organisational collective bargaining for workers, in terms of pay, job quality, working hours and work-life balance.

Design/methodology/approach

The paper is based upon two methodological approaches. First, econometric analyses using industry-level and firm-level data for advanced and emerging economies testing the relationship between declining union density, collective bargaining coverage and the fall in the share of wages in national income. Second, it reports on ten in-depth case studies of collective bargaining each based upon analysis of collective bargaining agreements plus in-depth interviews with the actors party to them: in total, 16 trade union officers, 16 members and 11 employer representatives.

Findings

There is robust evidence of the effects of different measures of bargaining power on the labour share including union density, welfare state retrenchment, minimum wages and female employment. The case studies appear to address a legacy of deregulated industrial relations. A number demonstrate the reinvigoration of collective bargaining at the organisational and sectoral level, addressing the two-tier workforce and contractual differentiation, alongside the consequences of government pay policies for equality.

Research limitations/implications

The case studies represent a purposive sample and therefore findings are not generalisable; researchers are encouraged to test the suggested propositions further.

Practical implications

The paper proposes that tackling income inequality requires a restructuring of the institutional framework in which bargaining takes place and a level playing field where the bargaining power of labour is more in balance with that of capital. Collective bargaining addresses a number of the issues raised by the Taylor Review of Modern Working Practices as essential for “good work”, yet is at odds with the review’s assumptions and remedies. The case studies reiterate the importance of the development of strong workplace representation and bargaining at workplace level, which advocates for non-members and provides a basis for union recruitment, organisation and wider employee engagement.

Originality/value

The paper indicates that there may be limits to employer commitment to deregulated employment relations. The emergence of new or reinvigorated collective agreements may represent a concession by employers that a “free”, individualised, deinstitutionalised, precarious approach to industrial relations, based on wage suppression and work intensification, is not in their interests in the long run.
The impact of operational risk incidents and moderating influence of corporate governance on credit risk and firm performance
Authors: Ko Chiungfeng , Lee Picheng , Anandarajan Asokan
Published: February 2019

Purpose

The purpose of this paper is to examine the association among operational risk incidents, corporate governance, credit risk and firm performance.

Design/methodology/approach

First, the authors regress corporate credit risk on the incurrence of operating losses (driven by operational risk events) and corporate governance variables. The purpose is to test the correlation between operational risk, corporate governance and credit risk. Second, in the authors’ next regression, the authors’ dependent variable is firm performance, and the independent variable is operational risk and corporate governance to test the correlation between operational risk, corporate governance and firm performance. In this study, the authors measure corporate governance using four surrogates, focusing on CEO duality, extent of independent board members, extent of foreign ownership and board member presence ratio.

Findings

The authors’ findings indicate that the higher level of operational risk incidents is linked to higher likelihood of credit default and to poorer performance. More importantly, the authors find that higher-quality corporate governance is associated with lower levels of operational risk incidents, better performance and lower likelihood of credit fault.

Originality/value

The authors use a rigid theoretical and empirical framework to examine the association among the incidents of operational risk, credit risk, corporate governance and firm performance. The authors’ study is important because it first facilitates understanding of causes leading to operational risk, and second if and how greater financial effects of operational risk negatively influences operating performance and credit risk of nonfinancial institutions in emerging markets.
Leverage and firm investment: the role of information asymmetry and growth
Authors: Danso Albert , Lartey Theophilus , Fosu Samuel , Owusu-Agyei Samuel , Uddin Moshfique
Published: February 2019

Purpose

This paper aims to demonstrate how financial leverage impacts firm investment and the extent to which this relationship is conditional on the level of information asymmetry as well as growth.

Design/methodology/approach

The paper relies on data from 2,403 Indian firms during the period 1995-2014, generating a total of 19,544 firm-year observations. Analysis is conducted by using various panel econometric techniques.

Findings

Drawing insights from agency theories, the paper uncovers that financial leverage is negatively and significantly related to firm investment. It is also observed that the impact of financial leverage on firm investment is significant for high information asymmetric firms. Finally, the paper shows that the relationship between leverage and firm investment is significant for low-growth firms. However, no significant relationship is found between leverage and investment for high-growth firms.

Originality/value

This paper provides fresh evidence on the leverage–investment nexus and, to the authors’ knowledge, it the first paper to examine the extent to which this leverage–investment relationship is driven by the level of information asymmetry.
Factors driving Indian consumer’s purchase intention of roof top solar
Authors: Aggarwal Ashwini Kumar , Syed Asif Ali , Garg Sandeep
Published: February 2019

Purpose

The solar energy sector has been growing with dramatic reduction in commercial pricing, improved efficiencies and improved deployments/usage conveniences. The purpose of this study is to understand the drivers of the purchase intent for rooftop (RT) solar. This will enable policymakers to improve the penetration of this new and promising green technology.

Design/methodology/approach

This research leverages the framework of unified theory of acceptance and use of technology 2 (UTAUT2) to identify and build a quantitative approach to identify factors (and their relative impact on) the purchase intent of a domestic RT solar buyer. The 400 respondents’ field data were collected in Bangalore (a high RT solar penetration region) and Delhi NCR (relatively lower RT solar penetration region).

Findings

The exploratory factor analysis study revealed that the consumers’ purchase intention of RT Solar is shaped by seven main factors, namely, environmental concerns, social beliefs, hedonic motivation, performance expectancy, price value, self-efficacy and effort expectancy, and that these factors explain 79.2 per cent of the field data. This study finds that social beliefs followed by effort expectance concerns are key factors explaining approximately 20 per cent of the purchase intent each, while unit change in price value beliefs explain about 18 per cent of the purchase intent.

Practical implications

Suggested policy measures include building on strengthening emergence of local solar evangelist groups in the communities and easing effort expectance items (e.g. building legal, regulatory frameworks and financial tools for solar penetration models such as renewable energy services companies).

Originality/value

This paper is the first attempt to model the consumer behavior of the Indian RT solar photovoltaic buyer leveraging the UTAUT2.
Logistics outsourcing in omnichannel retail
Authors: Buldeo Rai Heleen , Verlinde Sara , Macharis Cathy , Schoutteet Penelope , Vanhaverbeke Lieselot
Published: February 2019

Purpose

The purpose of this paper is to identify in what way logistics service providers are involved in the logistics operations of omnichannel retailers. Given the importance of logistics in omnichannel retail and the complexities that it brings forth, it is unclear if the current tendency towards logistics outsourcing continues, and how logistics service providers should adapt to remain relevant in the omnichannel retail environment.

Design/methodology/approach

The research draws on both desk and field research. The authors analysed the scientific information available on omnichannel retail logistics and conducted semi-structured expert interviews with food and non-food retailers that adopt an omnichannel model.

Findings

The research demonstrates distinct differences between food and non-food retailers. While food retailers are inclined to organise fulfilment and last mile activities in-house, non-food retailers partner closely with logistics service providers. Nonetheless, the store network of non-food retailers is attracting a growing part of logistics activities, which retailers are building themselves. To sustain their relevance in the omnichannel environment and strengthen their position for the future, the authors created a competency recommendation framework for logistics service providers, in which service differentiation is proposed as a viable direction for growth.

Research limitations/implications

The research is based on insights from retailers based in the Brussels-Capital Region (Belgium) and requires further and wider testing in other contexts and geographical areas.

Practical implications

The findings have strategic importance for retailers that are developing an omnichannel retail model and logistics service providers that (aim to) serve clients and operate activities within the retail sector.

Originality/value

The research provides a holistic view of logistics in omnichannel retail by identifying insourcing and outsourcing mechanisms and developing competency recommendations to fulfilment, internal transport and last mile transport in omnichannel retail.
Investigating online consumers’ responses to product presentation modes
Authors: Wang Yi-Shun , Yeh Ching-Hsuan , Wang Yu-Min , Tseng Timmy H. , Lin Hsin-Hui , Lin Shinjeng , Xie Min-Quan
Published: February 2019

Purpose

With the proliferation of virtual reality (VR) applications in electronic commerce, investigations on the effects of VR on consumer responses are important. The purpose of this paper is to examine the effects of online presentation modes (i.e. situational VR, pure VR and picture) on consumer responses for three product types (i.e. geometric, material and mechanical).

Design/methodology/approach

This study conducted a 3×3 between-subjects experiment to validate the research model and hypotheses.

Findings

The results revealed that both the situational VR mode and the pure VR mode had a greater impact on product knowledge and purchase intention than the picture mode. The situational VR mode yielded a higher level of product knowledge and purchase intention than the pure VR mode although it was not statistically significant. Furthermore, the pattern of VR modes superiority was found to be consistent across geometric, material and mechanical product types.

Originality/value

This research study contributes to the VR literature by investigating a new type of VR: situational VR, and offering a more comprehensive picture of consumer responses to online product presentations. The authors then drew the implications from the findings to suggest guidelines for practitioners to efficiently allocate resources and maximize the effectiveness of online presentation modes.
A novel operational approach to equipment maintenance: TPM and RCM jointly at work
Authors: Braglia Marcello , Castellano Davide , Gallo Mosè
Published: February 2019

Purpose

The purpose of this paper is to present a new operational approach to equipment maintenance designed to exploit the complementary nature of total productive maintenance (TPM) and reliability-centered maintenance (RCM).

Design/methodology/approach

This paper focuses on the operational aspect of the maintenance practice, proposing an equipment maintenance methodology that can be suitably adopted to define a new maintenance plan or check and improve an existing one. It integrates principles and methods of TPM and RCM and uses different tools to support decision-makers and operators. It proposes several worksheets which facilitate planning and implementing maintenance activities, that range from autonomous maintenance tasks to maintainability improvement actions.

Findings

This paper exploits the complementary nature of TPM and RCM to design or improve maintenance plans for a generic system. The tools and worksheets presented can be helpful to practitioners and operators.

Originality/value

While the integration of TPM and RCM is evidently a central issue in the maintenance management context, it has received limited attention in literature. To the best of the authors’ knowledge, it lacks a structured practical equipment maintenance methodology that exploits the complementary nature of TPM and RCM. Therefore, the approach presented in this paper would fill the current gap.
Entrepreneurial orientation and the mediating role of organisational learning amongst Indian S-SMEs
Authors: Mantok Stanzin , Sekhon Harjit , Sahi Gurjeet Kaur , Jones Paul
Published: February 2019

Purpose

The purpose of this paper is to examine organisational learning as a mediator among small-scale manufacturing enterprises (S-SMEs) which comprise the majority of economic activity in an emergent/developing economy. This study offers further understanding regarding the mediating role of organisational learning in developing world economies, due to its potential regional influence.

Design/methodology/approach

A cross-sectional survey of Indian S-SMEs was undertaken from the District Industrial Center. The study employed a systematic sampling technique to contact owner/managers. Overall, 204 S-SMEs owners/managers participated in the study and 192 usable survey instruments were received.

Findings

The study offers novel insights to the following questions. First, the factors that prompt entrepreneurial orientation to achieve superior business performance, i.e. the antecedents of entrepreneurial orientation? The results reveal competitor orientation is an antecedent of entrepreneurial orientation that leads to an S-SME’s business performance. Second, the outcomes of entrepreneurial orientation, i.e. the consequences of entrepreneurial orientation? The study reveals organisational learning and business performance are the corollary of entrepreneurial orientation. Third, the examination of whether organisational learning mediates the relationship between entrepreneurial orientation and business performance? The findings found the effects of entrepreneurial orientation on business performance are, in part, mediated by organisational learning.

Research limitations/implications

Three study limitations are recognised. First, other strategic orientations, including technology orientation, production orientation and selling orientation are not included. Second, other constructs have a potentially significant relationship with market and entrepreneurial orientation, such as organisational capabilities, innovation and social context, were not considered. Third, the study is industry-sector specific and does not consider alternative sectors which also may play a potential role in economic development.

Originality/value

This study enhances the existing S-SME literature by identifying factors contributing to entrepreneurial orientation and its repercussions on business performance. For S-SMEs it adds credence to the role played by organisational learning in mediating the link between entrepreneurial orientation and business performance which potentially encourages owner/managers to dedicate increased time and resources towards creating and maintaining a conducive learning environment. The results support entrepreneurs in acknowledging the importance of competitor orientation during the emergence and development of entrepreneurial orientation, specifically in emerging economy contexts.
Motivation of female entrepreneurs: a cross-national study
Authors: Solesvik Marina , Iakovleva Tatiana , Trifilova Anna
Published: February 2019

Purpose

This paper focuses on the motivation of females to start businesses in developed and emerging economies. Although the issues related to the motivation of entrepreneurs have been widely studied, there are a few studies focusing on the differences in women’s entrepreneurial motivation in countries with different levels of market economy development. Furthermore, existing studies on female founders mainly adapt the concepts that have often been developed in male-dominated paradigm. The purpose of this paper is to explore in depth motivations of female entrepreneurs in different contexts and discover the dissimilarities in women’s entrepreneurial motivations in countries with different levels of economic development.

Design/methodology/approach

The qualitative research approach is applied in this study to explore the social-driven and profit-driven motives of female entrepreneurs. The authors have employed purposeful sampling to select cases. The authors investigated the motivations of 45 female entrepreneurs in Norway (12), Russia (21) and Ukraine (12). Semi-structured interviews were used to collect primary data. The authors have also triangulated the data collected from interviews with the data available on the internet, company reports and newspaper publications.

Findings

The findings indicate that women often pursuit business opportunities to satisfy social needs, rather than focusing on traditional business outcomes such as growth or profit. However, different contexts – the emerging economies context of Russia and Ukraine and the developed one of Norway – seem to influence the motivation to establish new ventures differently. The study found a stronger desire to contribute to a society’s needs among female founders in Norway compared to their counterparts in Russia and Ukraine. This indicates that cultural and social context in developed countries, such as in Norway, probably provides more possibilities for female entrepreneurs for self-realisation elsewhere leaving more room for focusing on societal issues in business in comparison with emerging countries contexts.

Originality/value

A novel conceptual contribution is the exploration of links between the social-driven and profit-driven motives of female entrepreneurs in emerging and developed economises. The study also adds to debates relating to context embeddedness of smaller firms.
The moderating effect of career stage on the relationship between job embeddedness and innovation-related behaviour (IRB)
Authors: Rafiq Muhmmad
Published: February 2019

Purpose

The purpose of this paper is to re-examine the moderating effect of career stage on the relationship between job embeddedness and innovation-related behaviour (IRB).

Design/methodology/approach

Data were collected from a sample of 310 Chinese media organisation employees and were analysed using moderated structural equation modelling.

Findings

Career stage significantly moderated the relationship between job embeddedness and IRB; individuals who experienced high job embeddedness in their early career stage were found to be engaged in more IRBs than those who experienced low job embeddedness in their early career stage. Moreover, the author also found that individuals who experienced high job embeddedness at mid-late career stages were less engaged in IRB, as compared to those at earlier career stages.

Research limitations/implications

These findings contribute to the understanding of the relationship between employee job embeddedness and IRB at different career stages. The findings are limited by the cross-sectional nature of the data.

Originality/value

This study demonstrates that individuals at a mid-late career stage may define their work roles differently to those at an early career stage. Employers often expect individuals in the mid-late career stage to facilitate the work of others and to assist junior colleagues in their professional growth (Super et al., 1996).
Acoustic and petrophysical properties of mechanically compacted overconsolidated sands: part 1 – experimental results
Authors: Narongsirikul Sirikarn , Mondol Nazmul Haque , Jahren Jens
Published: February 2019

This paper part one is set out to lay primary observations of experimental compaction measurements to form the basis for rock physics modelling in paper part two. P‐ and S‐wave velocities and corresponding petrophysical (porosity and density) properties of seven unconsolidated natural sands with different mineralogical compositions and textures are reported. The samples were compacted in a uniaxial strain configuration from 0.5 up to 30 MPa effective stresses. Each sand sample was subjected to three loading cycles to study the influence of stress reduction on acoustic velocities and rock physical properties with the key focus on simulating a complex burial history with periods of uplift. Results show significant differences in rock physical properties between normal compaction and overconsolidation (unloaded and reloaded). The differences observed for total porosity, density, and P‐ and S‐wave velocities are attributed to irrecoverable permanent deformation. Microtextural differences affect petrophysical, acoustic, elastic and mechanical properties, mostly during normal consolidation but are less significant during unloading and reloading. Different pre‐consolidation stress magnitudes, stress conditions (isotropic or uniaxial) and mineral compositions do not significantly affect the change in porosity and velocities during unloading as a similar steep velocity–porosity gradient is observed. The magnitude of change in the total porosity is low compared to the associated change in P‐ and S‐wave velocities during stress release. This can be explained by the different sensitivity of the porosity and acoustic properties (velocities) to the change in stress. Stress reduction during unloading yields maximum changes in the total porosity, P‐ and S‐wave velocities of 5%, 25%, and 50%, respectively. These proportions constitute the basis for the following empirical (approximation) correlations: Δϕ∼ ±5 ΔVPand ΔVP∼ ±2ΔVS. The patterns observed in the experiments are similar to well log data from the Barents Sea. Applications to rock physics modelling and reservoir monitoring are reported in a companion paper.
Five overarching factors central to grammatical learning and treatment in children with developmental language disorder
Authors: Leonard Laurence B. , Kueser Justin B.
Published: February 2019

Background

During grammatical treatment of children with developmental language disorder (DLD), it is natural for therapists to focus on the grammatical details of the target language that give the children special difficulty. However, along with the language‐specific features of the target (e.g., for English, add –s to verbs in present tense, third‐person singular contexts), there are overarching factors that operate to render the children's learning task more, or less, challenging, depending on the particular target.

Aims

To identify five such factors that can play a role in the grammatical learning of children with DLD. We use English as our example language and provide supporting evidence from a variety of other languages.

Main Contribution

We show that the relative degree of English‐speaking children's difficulty with particular grammatical details can be affected by the extent to which these details involve: (1) bare stems; (2) opportunities for grammatical case confusion; (3) prosodic challenges; (4) grammatical and lexical aspect; and (5) deviations from canonical word order.

Conclusions

During treatment, therapists will want to consider not only the English‐specific features of grammatical targets but also how these more general factors can be taken into account to increase the children's success.
Speech and language therapists’ views on parents’ engagement in Parent–Child Interaction Therapy (PCIT)
Authors: Klatte Inge S. , Harding Sam , Roulstone Sue
Published: February 2019

Background

Parents’ play an essential role in Parent–Child Interaction Therapy (PCIT) as the primary agent of intervention with their child. Unfortunately, speech and language therapists (SLTs) report that parents’ engagement is challenging when conducting PCIT. Although focusing on and stimulating the engagement of parents, when needed, can increase the success of PCIT, little is known about what factors influence parent engagement.

Aims

To explore SLTs’ views about the factors that facilitate or pose barriers to parents’ engagement in PCIT.

Methods & Procedures

A secondary analysis of 10 interview transcripts about SLTs’ views on delivering PCIT with parents of children with developmental language disorder (DLD) was conducted. Codes from the original analysis where checked for their relevance to parents’ engagement by the first author. Potential themes were identified iteratively with all authors.

Outcomes & Results

Four themes were identified in the SLTs’ description of their experiences with the engagement of parents: mutual understanding, creating a constructive relationship between the SLT and parent, parental empowerment, and barriers. It became clear that SLTs were focusing on different aspects of engagement.

Conclusions & Implications

This study makes an initial contribution to our understanding of SLTs’ view of parents’ engagement and about what stimulates parent engagement or effects disengagement. SLTs play an important role in supporting parents to engage and stay engaged with therapy. Training SLTs on how best to engage parents, focusing on mutual understanding, creating constructive relationships between the SLT and parent, parental empowerment, and barriers, is necessary. However, more research is needed on how to train relevant skills in SLTs. Clearer definitions of engagement would improve understanding and judgements about how best to support parents.
Cold Case Homicides: DNA Testing of Retained Autopsy Sexual Assault Smears
Authors: Clark Michelle , Gill James , Sasinouski Kristin , McGuire Angela
Published: February 2019

Archival medical examiner specimens may contain perpetrator DNA evidence useful in unsolved (“cold case”) homicides. The Office of the Chief Medical Examiner (OCME) histology slide archives were searched for sexual assault smears for all 376 female homicides from 1990 to 1999. Of these, the OCME had sexual assault smears on 84 of which 13 slides had sperm. Of these 13, six were still unsolved. DNA profiles were obtained on all six (5 from smears and one from swabs). Combined DNA Index System ( submission resulted in two matches (“hits”) for new suspects. In addition, three suspects were eliminated in two cases. Our review of archival sexual assault smears resulted in DNA profiles that were able to assist in the investigation of four cold case homicide investigations. It may be worthwhile for medical examiner offices to search their archival histology slides for sexual assault smears on previously unsolved cases particularly those prior to the mid‐1990s when DNA testing was less widely available.
Diagnostic value of anti‐citrullinated fibrinogen antibody in rheumatoid arthritis: A meta‐analysis
Authors: Dai Zi‐Wei , Wang Zhi‐Hui , Dong Yuan‐Yuan , Wu Yue , Wang Hai‐Li , Wang De‐Guang , Wang Bin , Ye Dong‐Qing
Published: February 2019

Aim

To evaluate the overall diagnostic value of anti‐citrullinated fibrinogen (ACF) antibody in patients with rheumatoid arthritis (RA).

Methods

Published studies were systematically retrieved from PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Wan Fang, China Biology Medicine (CBM) disc, and Chinese VIP databases. QUADAS‐2 tool was applied to evaluate the quality of eligible studies. Subgroup analysis and meta‐regression were used to explore the sources of heterogeneity. Egger's test was used to evaluate for the presence of publication bias.

Results

Seven studies were included in this meta‐analysis. The pooled sensitivity, specificity, pooled positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio of ACF were 0.61 (95% CI: 0.57‐0.64), 0.93 (95% CI: 0.92‐0.94), 9.33 (95% CI: 5.15‐16.92), 0.39 (95% CI: 0.30‐0.53) and 24.58 (95% CI: 11.47‐52.64), respectively. The area under the curve was 0.8018. The results of subgroup analysis and meta‐regression indicated that the factors we analyzed might not be the leading causes of heterogeneity. No significant publication bias was found.

Conclusion

The ACF antibody had a moderate diagnostic accuracy on RA.
Prevalence and associated factors of small intestinal bacterial overgrowth among systemic sclerosis patients
Authors: Sawadpanich Kookwan , Soison Pisit , Chunlertrith Kitti , Mairiang Pisaln , Sukeepaisarnjaroen Wattana , Sangchan Apichat , Suttichaimongkol Tanita , Foocharoen Chingching
Published: February 2019

Background

Small intestinal bacterial overgrowth (SIBO) results in nutrient malabsorption and malnutrition, thereby increasing the morbidity and mortality in systemic sclerosis (SSc) patients.

Objectives

To evaluate the prevalence and associated factors of SIBO in SSc patients.

Method

A cross‐sectional study was conducted between July 2015 and January 2016 in SSc patients over 18, using the glucose H2/CH4 breath test to evaluate SIBO.

Results

Eighty‐nine SSc patients (30 male and 59 female) underwent the glucose H2/CH4 breath test. The mean age was 54.4. Twelve participants were positive for the glucose H2/CH4 breath test, yielding a SIBO prevalence of 13.5% (95% CI 7.2‐22.4) among SSc patients. A multivariate analysis revealed that duration of disease >5 years was significantly associated with SIBO (adjusted odds ratio 9.38; 95% CI 1.09‐80.47).

Conclusion

The prevalence of SIBO, using the glucose H2/CH4 breath test, is not common among Thai SSc patients. However, a positive result was associated with longer duration of disease.
Empirical metronidazole for patients with severe bacterial infection: A systematic review with meta‐analysis and trial sequential analysis
Authors: Petersen Marie Warrer , Perner Anders , Jonsson Andreas Bender , Bahador Marjan , Sjövall Fredrik , Møller Morten Hylander
Published: February 2019

Background

Metronidazole is the preferred empirical anti‐anaerobic agent for patients with suspected anaerobic infection. The balance between benefits and harms of empirical metronidazole is unclear. We aimed to assess patient‐important benefits and harms of empirical metronidazole vs placebo/no treatment in adult patients with severe bacterial infection of any origin.

Methods

We conducted a systematic review with meta‐analysis and trial sequential analysis of randomized clinical trials assessing empirical metronidazole vs placebo/no treatment in adult hospitalized patients with severe bacterial infection. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) statement, the Cochrane Handbook and the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology. A protocol and statistical analysis plan was published prior to conducting the review.

Results

We included a total of nine trials (n = 1753 patients), all of which were adjudicated as having high risk of bias. We found no difference in the primary outcome mortality within 90 days (relative risk 1.56, 95% confidence interval 0.39‐6.25). Fewer patients receiving metronidazole had secondary infections (relative risk 0.43, 95% CI: 0.27‐0.68). Trial sequential analysis indicated high risk of random errors due to lack of data, and the quality of evidence was very low for all outcomes.

Conclusions

There is low quantity and quality of evidence supporting the use of empirical metronidazole in adult patients with severe bacterial infections of any origin, and no firm evidence for benefit or harm.
Are Conditional Cash Transfer programs for women? Engendering the Philippine Pantawid
Authors: Mendoza Eva N.
Published: February 2019

Evaluation studies reveal positive outcomes of Conditional Cash Transfer program. This program, however, warrants an analysis using the lens of gender. Based on interview data among selected Pantawid's national, regional, provincial, and municipal personnel, as well as secondary data, this article finds that the program has limited impact on gender justice for it restricts the agency of mothers as grantees. For a social development program to perform democratizing functions, it must challenge unequal, patriarchal relations.
Cationic amino acid transporter PQLC2 is a potential therapeutic target in gastric cancer
Authors: Jeung Yun‐Ji , Lee Kyeong , Lee Hyo Jin , Kim Eunah , Son Myung Jin , Ahn Jiwon , Kim Han‐Gyeul , Kim Wantae , Lee Ho‐Joon , Kim Jin Man , Chung Kyung‐Sook
Published: February 2019

Tumor cells overexpress amino acid transporters to meet the increased demand for amino acids. PQ loop repeat‐containing (PQLC)2 is a cationic amino acid transporter that might be involved in cancer progression. Here, we show that upregulation of PQLC2 is critical to gastric cancer (GC) development in vitro and in vivo. Both PQLC2 mRNA and protein were overexpressed in GC tissues, especially of the diffuse type. Overexpression of PQLC2 promoted cell growth, anchorage independence, and tumor formation in nude mice. This was due to activation of MEK/ERK1/2 and PI3K/AKT signaling. Conversely, PQLC2 knockdown caused growth arrest and cell death of cancer cells and suppressed tumor growth in a mouse xenograft model. These results suggest that targeting PQLC2 is an effective strategy for GC treatment.
From conference abstract to publication in the conservation science literature
Authors: Verde Arregoitia Luis D. , González‐Suárez Manuela
Published: February 2019

Every 2 years, the conservation community comes together at The Society for Conservation Biology's International Congress for Conservation Biology (ICCB) to share new developments in conservation science and practice. Publication of findings presented at conferences in scientific journals adds to the permanent record and helps increase the potential impact of the work presented. However, quantitative research on publication rates for meetings relevant to conservation is lacking. For the 25th ICCB, (Auckland, New Zealand in 2011), we examined study publication rates and presenter demographics, recorded titles, number of authors, presenter affiliations, gender, country of the study region, publication status, and elapsed time between presentation and publication. Of the 980 contributions (782 talks and 198 posters), 587 (60%) were published as peer‐reviewed journal articles or book chapters. Mean time to publication was 13.7 months for all presentation abstracts and 21.3 months excluding abstracts with corresponding articles that were published before the meeting. The gender breakdown of presenters was almost even (53% male, 47% female), but representation of the countries where the presenting authors were based was skewed. The political units with the most contributions were by far the United States, Australia, New Zealand, and the United Kingdom. Presenters based in 16 different English‐speaking countries made up 74% of the total sample, but this did not influence the likelihood of their abstract leading to a publication. Examination of conference presenters and publication of their presentations is useful to identify biases and potential challenges that need to be addressed to make conference communications permanent and increase their reach beyond conference attendees.
Bees use anthropogenic habitats despite strong natural habitat preferences
Authors: Collado Miguel Á. , Sol Daniel , Bartomeus Ignasi
Published: February 2019

Aim

Habitat loss and alteration are widely considered one of the main drivers of current pollinator diversity loss. Yet little is known about habitat importance and preferences for major groups of pollinators, although this information is crucial to anticipate and mitigate the current decline of their populations. We aim to rank and assess the importance of different habitats for bees, to determine the preference for and avoidance of particular habitat types by different bees and to quantify the diversity of bees within and among habitats.

Location

North‐eastern USA.

Time period

The sampling was done over 15 years (2001–2015).

Major taxa studied

Apoidea.

Methods

We used an unprecedented extensive dataset of >15,000 bee specimens, comprising more than 400 species collected across north‐east USA. We extracted habitat information from the sample points and used network analyses, null models comparisons and beta‐diversity analysis to assess habitat importance, habitat preference, use and diversity.

Results

We found that natural habitats sustain higher bee diversity and a different set of species than agricultural and urban areas. Although many bee species used human‐altered habitats, most species exhibited strong preferences for forested habitats and only a few preferred altered habitats over more natural habitats. In contrast to previous studies, landscape composition only had moderate buffer effects on diversity loss. The loss of biodiversity in human‐altered environments could have been higher but it was partially compensated by the presence of human commensals and exotic species.

Main conclusions

Although human‐altered environments may harbour a substantial number of species, our work suggests that preserving natural areas is still essential to guarantee the conservation of bee biodiversity.
Mortality due to cardiovascular disease, respiratory disease, and cancer in adults with cerebral palsy
Authors: Ryan Jennifer M , Peterson Mark D , Ryan Nicola , Smith Kimberley J , O'connell Neil E , Liverani Silvia , Anokye Nana , Victor Christina , Allen Elizabeth
Published: February 2019

Aim

To compare mortality rates for cardiovascular disease, cancer, and respiratory disease between adults with cerebral palsy (CP) and the general population.

Method

A cohort study was conducted using data from adults with CP in England, identified through a primary care data set (the Clinical Practice Research Datalink), with linked data on death registrations from the Office for National Statistics. Cause of death was categorized according to International Classification of Diseases codes. Standardized mortality ratios (SMRs) were calculated to compare mortality rates between adults with CP and the general population, adjusted for age, sex, and calendar year.

Results

Nine hundred and fifty‐eight adults with CP were identified (52.5% males, 47.5% females; median age at start of follow‐up 31y [interquartile range 22–43y]) and followed for a total of 7693 person‐years. One hundred and forty‐two patients (15%) died during follow‐up. Adults with CP had an increased risk of death due to cardiovascular disease (SMR: 3.19, 95% confidence interval [CI] 2.20–4.62) and respiratory disease (SMR: 13.59, 95% CI 9.89–18.67), but not from malignant neoplasms (SMR: 1.42, 95% CI 0.83–2.45).

Interpretation

We found that adults with CP in England have increased risk of death due to diseases of the circulatory and respiratory systems, supporting findings from two studies that compared cause‐specific mortality rates between adults with CP in the USA and the general population. Further research is required into primary and secondary prevention of cardiovascular and respiratory disease in people with CP worldwide.

What this paper adds

Adults with cerebral palsy (CP) in England have 14‐fold increased risk of mortality due to diseases of the respiratory system.

They have a 3‐fold increased risk of mortality due to diseases of the circulatory system.

Adults with CP had an increased risk of death due to cerebrovascular disease and ischaemic heart disease.

The elevated risk of ischaemic heart disease, however, did not reach statistical significance at the 5% per cent level.
Social Justice and Race in the United States: Key Issues and Challenges for Couple and Family Therapy
Authors: Watson Marlene F.
Published: February 2019

Social justice tends to be narrowly defined as equality without due recognition of human dignity and respect for those whose daily lives continue to be adversely impacted by race. This article seeks to explore key issues and challenges at the intersection of social justice and race for couple and family therapy. These include: (a) defining social justice; (b) diversity and inclusion; (c) power and privilege; (d) witness; and (e) personal responsibility.