bluuebunny/crossref_metadata_2025 huggingface dataset:
THE ANALYSIS OF EXISTING EXPERIENCE FOR THE ETHNOBOTANICAL INFORMATION SYSTEM
Authors: Hamidova Laman Faig
Published: June 2019

Ethnobotanical researches reflect the conventional learning of a region. Over the previous decade, medical plants which used for healing indigenous people has become a significant notion among the people and impacted improvement of scientific and ethnobotanical knowledge and investigations of eliminating health problems. A public database has been based on data assembled from various verifiable sources, including journals, travel records, and treatises on therapeutic plants, composed by explorers, botanists, doctors, researchers who went to the nations during the most recent three centuries. In addition, ethnobotanical data depicted in chronicled natural accumulations and in Ancient and Medieval writings from the inquired district have been incorporated into the database. The databases have to be sufficiently adaptable to illustrate a valuable tool for analysts who need to store and analyze present and past ethnobotanical data from the researched location. The ethnobotanical researches are improved in Azerbaijan day by day. The database is used for informing people about some national plants which are growing in the different region of Azerbaijan. The ethnobotanical databases from different countries are analyzed in this article.

There are used some special methods for comparing the differences among these databases as data mining and text mining. As a first step the suitable databases are gathered for our investigation, then are defined the best information systems that are used in many countries’ biologists and scientists and the end is observed advantages and disadvantages of all existing ethnobotanical databases which we researched. The features of information systems are evaluated. The results demonstrated each of databases has its very own quality, but none has turned a standard form for universal research. The reason is very basic: none of these databases enable specialists to include their own information. There is also illustrated sample structure, main tables and key components of the ethnobotanical database.

The obtained results, while a few ethnobotanical databases existing, none are satisfactory answers for worldwide work, and none enable analysts to include their very own information. There is a need brought together all essential properties of existing databases, and creating a free database that encourages ethnobotanical research. Due to the rise and quick improvement in the field of data advances, it has now turned out to be conceivable to digitize, oversee and make ethnobotanical information accessible to a more extensive gathering of people.
Important factors which predict entrepreneur’s perception in business risk
Authors: Çera Gentjan , Belás Jaroslav , Strnad Zdeněk
Published: June 2019

This paper seeks to examine the role of factors originated from outside (economic, political, competitive environment and relationships) and within (entrepreneur’s attitude) the organization on the business risk perceived by entrepreneurs. To test the hypothetical relationships, an ordinal regression with two link functions was applied on an original dataset of 641 small and medium-sized enterprises (SMEs) operating in Slovakia and Czech Republic. The analysis revealed that not only economic factors can predict business risk, but along with them are political and competitive environments, relationship with supply chain actors and entrepreneur’s attitude. Consistent with prior research, it is found that an unstable economic environment leads the business to expose themselves to business risk. Also, a friendly regulation framework and quality education contribute significantly to reducing the level of risk. The research triggers the interest of policymakers who design policies aimed at improving the business environment by reducing the level of risk that firms face in doing business. Also, this paper is useful for managerial perspective, since entrepreneur attitude was found to be a predictor of business risk.
Fault detection in level and flow rate sensors for safe and performant remote-control in a water supply system
Authors: Fellini Sofia , Vesipa Riccardo , Boano Fulvio , Ridolfi Luca
Published: June 2019

This work presents an algorithm for real-time fault detection in the SCADA system of a modern water supply system (WSS) in an Italian alpine valley. By means of both hardware and analytical redundancy, the proposed algorithm compares data and isolates faults on sensors through analysis of residuals. Moreover, the algorithm performs a real-time selection of the most reliable measurements for the automated control of the WSS operations. A coupled model of the hydraulic and remote-control system is developed to test the performance of the WSS when the proposed algorithm is applied or not. Simulations show that the occurrence of errors in the sensors causes significant worsening in the economic, energy and mechanical performance of the infrastructure. In many cases, the operations of the WSS are seriously compromised. The error detection and measurement assessment performed by the proposed algorithm proves to be crucial for the safe control of the WSS.
O ceticismo antifideísta de Hume
Authors: Santos Rafael Bittencourt
Published: June 2019

O ceticismo de Hume pode parecer próximo do fideísmo cético em virtude da sua crítica às faculdades humanas envolvidas no conhecimento da verdade e da sua defesa da necessidade de um mecanismo não racional como fundamento das nossas crenças. A diferença entre ambos estaria na identificação da solução para a suspensão do juízo resultante da descoberta da insuficiência da razão para compreender o mundo e guiar a ação: um apontaria para a determinação natural, outro, para a Revelação. Argumento aqui que essa proximidade não é mais do que aparente. A filosofia de Hume constitui-se como antifideísta não apenas por razões prudenciais, práticas ou pragmáticas, mas também pelos seus fundamentos filosóficos. Para mostrá-lo, examino a discussão entre Dêmeas e Filão nos Diálogos sobre a Religião Natural, a investigação sobre a origem da religião na História Natural da Religião e as razões para a recomendação da filosofia ante a superstição no Tratado da Natureza Humana.
ANTROPOLOGIA EDUCACIONAL: A CONSOLIDAÇÃO DE UMA SUBÁREA EPISTEMOLÓGICA
Authors: Regert Rodrigo , Santos Adélcio Machado dos
Published: June 2019

O objeto da Antropologia engloba as maneiras físicas primitivas e atuais relacionadas ao homem e as suas manifestações culturais. Atribui-se a essa área epistêmica a faina de proceder às generalizações, estabelecendo princípios explicativos do desenvolvimento e da formação das sociedades e culturas humanas. A Antropologia Cultural constitui a subárea mais ampla, visto que abrange o estudo do humano em sua ontologia, ou seja, gerador de cultura. Igualmente, analisa as culturas humanas no tempo e no espaço, suas origens e desenvolvimento, suas semelhanças e discrepâncias. Tem enfoque de interesse voltado para o conhecimento do comportamento cultural humano, obtido por aprendizado, considerando-o em todas as suas dimensões. Tal como para a Antropologia e para a Educação, a diversidade humana representa grande riqueza de problema heurístico a demandar pesquisa. Ademais disso, a abordagem antropológica da educação opera com missão relevante: analisa a construção do conhecimento contextualizado socialmente. Em epítome, a Antropologia Educacional se configura jovem, contudo auspiciosa subárea epistemológica. Por isso o objetivo do presente artigo é analisar a contribuição que a Antropologia pode oferecer a Educação. O mesmo trata-se de uma pesquisa descritiva com base bibliográfica. Conclui-se que a Antropologia é plural e está sempre aberta ao diferente, não permitindo que o seu saber se consolide de forma precipitada. A Antropologia da Educação viabiliza uma análise adequada da complexidade, da interculturalidade e das novas tecnologias que são as grandes incógnitas do saber pedagógico.
CAPUXU - DE VESPA A GRUPO SOCIAL: A PRODUÇÃO DA ETNICIDADE EM UMA COMUNIDADE CAMPONESA NO SERTÃO DA PARAÍBA
Authors: Sousa Emilene Leite
Published: June 2019

Neste artigo, objetivo apresentar o povo Capuxu, um grupo camponês endogâmico do sertão da Paraíba, como grupo étnico. Para isso faço uma análise do grupo e sua identidade coletiva a partir das teorias de etnicidade utilizando-me do instrumental teórico de Weber (1921) e Barth (1969). O povo Capuxu constitui um grupo cuja diferenciação está nitidamente marcada através da produção de fronteiras e de um forte sentimento de pertença que envolve o povo tendo sido a estes dois elementos que eu me dediquei em campo. Além disso, analiso os sinais diacríticos do povo, sendo estes: a aparência comum aos membros do grupo; o sotaque peculiar; o etnônimo; o sistema endogâmico de parentesco; e a contigüidade territorial. A partir destes três vetores: produção de fronteiras, sentimento de pertença e sinais diacríticos, realizo uma análise da produção da etnicidade Capuxu e das estratégias de permanência e reprodução social de um grupo camponês que se esforça por manter seu ethos e sua identidade coletiva.
Molecular Docking Study of Active Diazenyl Scaffolds as Inhibitors of Essential Targets Towards Antimicrobial Drug Discovery
Authors: Kaur Harmeet , Gahlawat Sudhir , Singh Jasbir , Narasimhan Balasubramanian
Published: June 2019

Background:

The diazenyl compounds (-N=N- linkage) have been reported to have antimicrobial
activity. In modern drug discovery, the drug-receptor interactions are generally explored by the
molecular docking studies.

Materials and Methods:

Three categories of diazenyl scaffolds were screened for the docking studies
to explore the binding mechanism of interaction with various microbial targets. The diazenyl Schiff
bases (SBN-20, SBN-21, SBN-25, SBN-33, SBN-39, SBN-40 and SBN-42), naphthol pharmacophore
based diazenyl Schiff bases (NS-2, NS-8, NS-12, NS-15, NS-21, and NS-23), morpholine based diazenyl
chalcones (MD-6, MD-9, MD-14, MD-16, MD-20, and MD-21) were docked against various
bacterial and fungal proteins in comparison with different standard drugs. Further, the drug likeliness
and ADME properties of these molecules were predicted by QikProp module of the Schrodinger software.

Results:

Most of the derivatives had shown less docking scores and binding energies towards bacterial
proteins, such as dihydropteroate synthase (PDB:2VEG), glucosamine-6-phosphate synthase
(PDB:2VF5), dihydrofolate reductase (PDB:3SRW) in comparison with the standard drugs. The naphthol
based diazenyl Schiff bases NS-21 and NS-23 were predicted to act on the cytochrome P450 sterol
14-alpha-demethylase (CYP51) (PDB:5FSA) involved in sterol biosynthesis, an essential target for
antifungal drugs. The derivative MD-6, NS-2, NS-21, and NS-23 had shown high docking scores
against bacterial DNA topoisomerase (PDB:3TTZ) in comparison with the standard drug ciprofloxacin.
Further, most of the synthesized derivatives had shown drug like characters.

Conclusion:

Hence, these compounds can be developed as novel antibacterial agents as potent DNA
topoisomerase inhibitors and antifungal agents as CYP51 inhibitors.
High Mobility Group Box-1 (HMGB1): A Potential Target in Therapeutics
Authors: Vijayakumar Eyaldeva C. , Bhatt Lokesh Kumar , Prabhavalkar Kedar S.
Published: June 2019

High mobility group box-1 (HMGB1) mainly belongs to the non-histone DNA-binding protein.
It has been studied as a nuclear protein that is present in eukaryotic cells. From the HMG family,
HMGB1 protein has been focused particularly for its pivotal role in several pathologies. HMGB-1 is
considered as an essential facilitator in diseases such as sepsis, collagen disease, atherosclerosis, cancers,
arthritis, acute lung injury, epilepsy, myocardial infarction, and local and systemic inflammation.
Modulation of HMGB1 levels in the human body provides a way in the management of these diseases.
Various strategies, such as HMGB1-receptor antagonists, inhibitors of its signalling pathway, antibodies,
RNA inhibitors, vagus nerve stimulation etc. have been used to inhibit expression, release or activity
of HMGB1. This review encompasses the role of HMGB1 in various pathologies and discusses
its therapeutic potential in these pathologies.
Computational Analysis of Arginine Deiminase Sequences to Provide a Guideline for Protein Engineering
Authors: Zarei Mahboubeh , Rahbar Mohammad Reza , Nezafat Navid , Negahdaripour Manica , Morowvat Mohammad Hossein , Ghasemi Younes
Published: June 2019

Background:

Arginine deiminase of Mycoplasma hominis, an arginine catabolizing enzyme, is currently in clinical trial for the treatment of arginine auxotrophic cancers. However, some drawbacks such as instability and antigenicity have limited its application as a protein drug. Arginine Deiminase (ADI) belongs to the guanidino-group modifying enzyme superfamily. Despite differences in the primary amino acid sequences of various members of this superfamily, the folding and secondary structures are conserved in all members. Despite structural similarities, ADIs in various species have different levels of catalytic activity and physicochemical properties due to the differences in their primary amino acid sequences. Therefore, investigating and comparing sequences between different ADI producing bacterial strains could be helpful in the rational engineering of ADI.

Objective:

In the current research, we used an in-silico approach to characterize and classify the available reviewed protein sequences of ADI.

Results:

102 ADI sequences from SwissProt database were extracted. Subsequently, based on clustering analyses, the sequence sets were divided into five distinct groups. Different physicochemical properties, solubility, and antigenicity of the enzymes were determined. Some ADI sequences were introduced as well-suited candidates for protein engineering; Lactobacillus fermentum ADI for low pI value, Mycobacterium avium ADI for high aliphatic index, Bacillus licheniformis ADI for low GRAVY index, Bradyrhizobium diazoefficiens ADI for low antigenicity and high stability index, and among Mycoplasma ADIs, Mycoplasma arthritidis ADI for high stability and aliphatic index, and Mycoplasma capricolum for low antigenicity.
Methods for Synthesis of α-Alkyl α,β-Unsaturated Aldehydes
Authors: Verochkina Ekaterina A.
Published: June 2019

α-Substituted α,β-unsaturated aldehydes represent a highly reactive class of compounds with a broad scope of application. Therefore, the development of methods for the synthesis of these bifunctional compounds is a dynamically progressing area of research. This review summarizes and highlights methods for the synthesis of α-alkyl α,β-alkenals.
Chiral catalysts utilized in the nucleophilic addition of dialkyl-zinc reagents to aldehydes
Authors: Cetin Adnan
Published: June 2019

The aim of this review is to supply an overview of diverse dialkyl zinc pro-chiral aldehydes addition reactions. One way of conducted asymmetric reactions is to use chiral catalyst. Therefore, the new chiral ligands are attracted considerable attention in the organic chemistry. Carbon-carbon bond formation reactions are an active research topic. The dialkyl zinc pro-chiral aldehydes addition reaction is one of these popular reactions. Also, the chiral amino alcohol molecules are important substrates in the drug synthesis. These chiral ligands can prepare from easily accessible starting materials by a simple synthetic way for practical applications. This review is presented the important catalyst reactions to addition dialkyl zinc to aldehydes.
Phytochemical and Pharmacological Review on Two Herbs of Baijiangcao: Patrinia scabiosaefolia Fisch. ex Trev. and Patrinia villosa (Thunb.) Juss
Authors: Liu Yangcheng , Liu Wei , Wang Jiaqi , Liu Yang , Chen Changlan , Xiang Zheng
Published: June 2019

Patrinia scabiosaefolia Fisch. Trev. and Patrinia villosa (Thunb.) Juss, are two species of
Patrinia recorded in the Chinese Pharmacopoeia with the same Chinese name “Baijiangcao” and similar
therapeutic effect in traditional Chinese medicine. The present article is the first comprehensive
review on the chemical composition and pharmacological activities of these herbs. In this review, data
on chemical constituents and pharmacological profile of the two herbs are provided. This review
discusses all the classes of the 223 compounds (phenylpropanoids, flavonoids, terpenes, saponins and
volatile components, etc.) detected in the two herbs providing information on the current state of
knowledge of the phytochemicals present in them. In the past three years, our research group has isolated
and identified about more than 100 ingredients from the two herbs. Therefore, we published a
systematic review of our research papers and studies on the two herbs were carried out using resources
such as classic books about Chinese herbal medicine and scientific databases including Pubmed,
Web of Science, SciFinder, CNKI. etc. The present review discusses the most thoroughly studied
pharmacological activities (antioxidant, anti-inflammatory, immunomodulatory, antimicrobial,
antitumor and antiviral activities) of the two herbs. This comprehensive review will be informative
for scientists searching for new properties of these herbs and will be important and significant for the
discovery of bioactive compounds from the two herbs and in complete utilization of Patrinia scabiosaefolia
Fisch. ex Trev. and Patrinia villosa (Thunb.) Juss.
Small-Molecule CSF1R Inhibitors as Anticancer Agents
Authors: Xun Qiuju , Wang Zhen , Hu Xianglong , Ding Ke , Lu Xiaoyun
Published: June 2019

Persuasive evidence has been presented linking the infiltration of Tumor-Associated Macrophages (TAMs) with the driving force of tumorigenesis and in the suppression of antitumor immunity. In this context CSF1R, the cellular receptor for Colony Stimulating Factor-1 (CSF1) and Interleukin 34 (IL-34), occupies a central role in manipulating the behavior of TAMs and the dysregulation of CSF1R signaling has been implicated in cancer progression and immunosuppression in many specific cancers. Consequently, CSF1R kinase has been a target of great interest in cancer treatment and significant research efforts have focused on the development of smallmolecule CSF1R inhibitors. In this review, we highlight current progress on the development of these small molecule CSF1R inhibitors as anticancer agents. Special attention is paid to the compounds available in advanced clinical trials.
Molecular Epidemiology of Streptococcus equi subsp. zooepidemicus Isolated from Thoroughbred Horses Using Multi Locus Sequence Typing (MLST) in Korea
Authors: Choi Seong-Kyoon , Park Chul-Song , Cho Gil-Jae
Published: June 2019

Background:

Multi Locus Sequence Typing (MLST) is a new global molecular typing method used for analyzing the DNA polymorphisms in bacteria. In this study, using MLST, we analyzed the sequence profiles ofStreptococcus (S.) zooepidemicusisolates from the Jeju and Jangsu provinces in South Korea.

Objective:

This study characterized the molecular epidemiology ofS. zooepidemicusinfection in Thoroughbred horses using MLST with an aim to control and prevent bacterial endometritis in mares.

Methods:

A total of 79S. zooepidemicusisolates were included in this study. Sequencing of the 7 loci for the MLST analysis was performed as described in the MLST website manual (http://pubmlst.org/szooepidemicus/) with some modifications. For each locus, every unique sequence was assigned a distinct allele number, and each Sequence Type (ST) was defined by a series of 7 integers (the allelic profile) corresponding to the alleles at the 7 loci (arcC,nrdE,proS,spi,tdk,tpi, andyqiL)using the MLST module in the Main Workbench.

Results:

Among the 79 isolates, 73 different MLST patterns were identified, each corresponding to 1-3 strains. The genetic relationships between the 79 isolates are presented in a dendrogram, and they diverged by up to 11% homology. At 11% homology, three MLST groups, M1, M2, and M3, were identified, and at 26% homology, five subgroups, L1-L5, were observed.

We observed various MLST patterns in the strains isolated from Jeju and Jangsu. In addition, by estimating the epidemiological relationships among the strains isolated from Jangsu in 2007 and Jeju in 2009, which had similar MLST patterns, we determined that some strains from Jangsu may have been transported to Jeju.

Conclusion:

MLST can be used as a framework for determining the epidemiological relationships that form the genetic basis of host and infection site selection.
Phytochemical Constituents, HPLC-PDA-ESI-MS/MS Profile and Bioactivities of Roots and Rhizomes of Prosopis farcta (Banks & Sol.) J. F. Macbr.
Authors: Ahmed Eman F. , Sleem Amany A. , Abbas Fawkeya A. , El-Shafae Azza M. , El-Domiaty Maher M.
Published: June 2019

Background:

The literature survey revealed that there are no sufficient phytochemical and biological studies on the roots and rhizomes of Prosopis farcta (Banks & Sol.) J. F. Macbr., therefore, the present work is concerned with the phytochemical and biological evaluation of this plant.

Methods:

The shade-dried roots and rhizomes were powdered together, extracted by 85% ethanol and subjected to phytochemical investigation. Biologically, the antioxidant, antidiabetic, cytotoxic, antiallergic and antimicrobial activities were evaluated.

Results:

The phytochemical investigation resulted in the isolation of 14 compounds including the fatty acid derivative, threo- methyl 9, 10-dihydroxyoctadecanoate (5), that is isolated for the first time from a natural source, in addition to the identification of 72 compounds by HPLC-PDA-ESIMS/ MS analysis including organic acids and their derivatives, flavonoids, anthraquinones and lignan derivatives. Biologically, threo- methyl 9, 10-dihydroxyoctadecanoate (5) exerted a potent cytotoxic effect against human lung carcinoma (A-549) and human colon carcinoma (HCT-116) cell lines. The total alcoholic extract showed a potent DPPH scavenging activity, a significant decrease in the blood glucose level in alloxan-induced diabetic rats and a mild antibacterial effect against Bacillus subtilis, Staphylococcus aureus (G +ve bacteria) and Escherichia coli (G –ve bacteria).

Conclusion:

This is the first report on the isolation and identification of threo- methyl 9, 10- dihydroxyoctadecanoate (5) from a natural source, and this novel compound exhibited potent cytotoxic activities against A-549 and HCT-116 cell lines. Moreover, this is the first HPLC-PDA-ESIMS/ MS profiling for this plant.
Efficacy of Essential Oil and Hydrosol Extract of Marrubium vulgare on Fungi Responsible for Apples Rot
Authors: Zatla Amina Tabet , Mami Imane , Dib Mohammed El Amine , Sifi Mohammed El Amine
Published: June 2019

Background:

The microorganisms such as Penicillium expansum and Botrytis cinerea are wellknown
pathogens in apples during postharvest. So, to protect apples from these pathogens, chemical control
methods were exercised.

Introduction:

The main objective of this work was to study the chemical composition and the in-vitro and
in-vivo antifungal properties of essential oil and hydrosol extract of Marrubium vulgare.

Methods:

In this work, the air-dried aerial parts of Marrubium vulgare were hydrodistilled in a Clevengertype
apparatus. The essential oil and hydrosol extract isolated were analyzed using Gas Chromatography
(GC) and Mass Spectrometry (GC/MS). The in-vitro antifungal activity of the both extracts was investigated
against Botrytis cinerea, Penicillium expansum and Alternaria alternata fungi using radial growth technique.
The effect of the essential oil and hydrosol extract on disease development of apple caused by Penicillium
expansum in the in-vivo conditions was assessed.

Results:

The essential oil of Marrubium vulgare was characterized principally by E-β-caryophyllene
(23.5%), E-β-farnesene (21%), α-humulene (14.8%), β-bisabolene (11.1%), caryophyllene oxide (6.8%) and
phytol (3.1%). While, the methyl-eugenol (65.5%), α-Bisabolol (12.5%), linalool (6.5%) and caryophyllene
oxide (6.2%) were the major compounds of hydrosol extract. The result of in-vitro antifungal activity of
hydrosol extract showed an interesting antifungal inhibition against Botrytis cinerea, Penicillium expansum
and Alternaria alternata with percentage inhibition ranging from 77% to 89% at low concentration of 0.15
mL/L. The essential oil was found to inhibit the growth of Penicillium expansum in a dose-dependent manner,
with a percentage inhibition of 100% at 30 mL/L. Furthermore, essential oil and hydrosol extract have
demonstrated promising in-vivo antifungal activity to control infection of apples by Penicillium expansum
up to 25th day of storage, compared with the control.

Conclusion:

The preventive and protective effects of essential oil and hydrosol extract could be exploited as an
ideal alternative to synthetic fungicides for using the protection of stored apples from fungal phytopathogens.
Магнитометр на основе структуры высокотемпературный сверхпроводник-эпитаксиальная феррит-гранатовая пленка
Authors: Протасов Е.А.
Published: June 2019

A physical justification is given and a schematic diagram is proposed for constructing a magnetometer by the method of periodic spatial modulation of the magnetic flux density by a multi-element HTSC structure and its subsequent measurement by a planar magneto-optical device with a sensitivity no worse than 10-12 T.
Эволюция интенсивных световых импульсов в нелинейной среде с учетом эффекта Рамана
Authors: Иванов С.К. , Камчатнов А.М.
Published: June 2019

AbstractThe evolution of high-intensity light pulses in nonlinear single-mode optical waveguides, the dynamics of light in which is described by the nonlinear Schrödinger equation with a Raman term taking into account stimulated Raman self-scattering of light, is investigated. It is demonstrated that dispersive shock waves the behavior of which is much more diverse than in the case of ordinary nonlinear Schrödinger equation with a Kerr nonlinearity are formed in the process of evolution of pulses of substantially high intensity. The Whitham equations describing slow evolution of the dispersive shock waves are derived under the assumption of the Raman term being small. It is demonstrated that the dispersive shock waves can asymptotically assume a stationary profile when the Raman effect is taken into account. Analytical theory is corroborated by numerical calculations.
Efficacy of an Electronic Health Management Program for Patients With Cardiovascular Risk: Randomized Controlled Trial (Preprint)
Authors: Yun Young Ho , Kang EunKyo , Cho Young Min , Park Sang Min , Kim Yong-Jin , Lee Hae-Young , Kim Kyae Hyung , Lee Kiheon , Koo Hye Yeon , Kim Soojeong , Rhee YeEun , Lee Jihye , Min Jeong Hee , Sim Jin-Ah
Published: June 2019

BACKGROUND

In addition to medication, health behavior management is crucial in patients with multiple risks of cardiovascular mortality.

OBJECTIVE

This study aimed to examine the efficacy of a 3-month Smart Management Strategy for Health–based electronic program (Smart Healthing).

METHODS

A 2-arm randomized controlled trial was conducted to assess the efficacy of Smart Healthing in 106 patients with at least one indicator of poor disease control and who had hypertension, diabetes, or hypercholesterolemia. The intervention group (n=53) took part in the electronic program, which was available in the form of a mobile app and a Web-based PC application. The program covered 4 areas: self-assessment, self-planning, self-learning, and self-monitoring by automatic feedback. The control group (n=53) received basic educational material concerning disease control. The primary outcome was the percentage of participants who achieved their clinical indicator goal after 12 weeks into the program: glycated hemoglobin (HbA1c) <7.0%, systolic blood pressure (SBP) <140 mmHg, or low-density lipoprotein cholesterol <130 mg/dL.

RESULTS

The intervention group showed a significantly higher success rate (in comparison with the control group) for achieving each of 3 clinical indicators at the targeted goal levels (P<.05). Only the patients with hypertension showed a significant improvement in SBP from the baseline as compared with the control group (72.7% vs 35.7%; P<.05). There was a significant reduction in HbA1c in the intervention group compared with the control group (difference=0.54%; P≤.05). In the intervention group, 20% of patients with diabetes exhibited a ≥1% decrease in HbA1c (vs 0% among controls; P≤.05).

CONCLUSIONS

A short-term self-management strategy-based electronic program intervention may improve clinical outcomes among patients with cardiovascular risks.

CLINICALTRIAL

ClinicalTrials.gov NCT03294044; https://clinicaltrials.gov/ct2/show/NCT03294044
Efficacy of a Mobile Texting App (HepTalk) in Encouraging Patient Participation in Viral Hepatitis B Care: Development and Cohort Study (Preprint)
Authors: Hyun Chul , McMenamin Joseph , Ko Okhyun , Kim Soonsik
Published: June 2019

BACKGROUND

Chronic hepatitis B virus (HBV) infection is a major cause of liver-related morbidity and mortality among Asian Americans in the United States. Despite the available resources, a majority of HBV-infected individuals are not able to access adequate health care owing to numerous barriers.

OBJECTIVE

This study aimed to assess the efficacy of a newly developed mobile texting app (HepTalk) in overcoming these barriers and improving patient engagement and health care access among HBV-infected and nonimmune individuals.

METHODS

HepTalk was employed for two-way communication between participants and patient navigators. A total of 82 Korean American participants who were either HBV infected or nonimmune to HBV, identified from a community hepatitis B campaign in New York, were enrolled in the study. After informed consent was obtained, both the frequency and themes of the text messages were evaluated. The effects of this communication on linkage to care at the end of the 6-month intervention period were analyzed and discussed.

RESULTS

On average, patient navigators sent and received 14 and 8 messages per participant, respectively, during the 6-month period. The themes of the messages were similar to the following 4 categories: finding providers, scheduling appointments with providers, health education, and financial issues. Of the 82 participants, 78 were linked to care within 6 months (a 95% linkage rate).

CONCLUSIONS

HepTalk may be employed as an effective and strategic tool to facilitate communicative interaction between patients and patient navigators or health care providers, thereby improving patient engagement and health care access.
Operation Streamline: consecuencias jurídicas y económicas para inmigrantes mexicanos deportados en la región Arizona-Sonora
Authors: Antonio López Ramiro , Valdéz-Gardea Gloria Ciria
Published: June 2019

El objetivo del artículo es analizar las consecuencias jurídicas y económicas de la política migratoria de tolerancia cero de Estados Unidos hacia inmigrantes mexicanos, jefes de familias de estatus migratorio mixto y deportados en la región Arizona-Sonora. En este estudio cualitativo se utilizó el método etnográfico, y se aplicó la observación participante y la entrevista semiestructurada, para recabar información de los migrantes deportados por Nogales, México, después de haber sido procesados con la Operation Streamline, y de cumplir su sentencia. Se utilizó el concepto de violencia estructural como marco interpretativo. Según los resultados, la aplicación de esta política migratoria violenta los derechos humanos de los migrantes en perjuicio de su economía personal y familiar. Los hallazgos demuestran que la criminalización de la migración indocumentada, cuando se aplica la Operation Streamline, vulnera los derechos humanos del deportado y trasforma la dinámica familiar, al producir una separación obligada, que es dolorosa y tiene amplias ramificaciones.
PATIENT-CENTERED MEDICINE: BACKGROUND TO THE TRANSFORMATION AND COMPONENTS
Authors: Khalfin R. A. , Madyanova V. V. , Kachkova O. E. , Demina I. D. , Krishtaleva T. I. , Dombrovskaya E. N. , Milchakov K. S. , Rozalieva Yu. Yu.
Published: June 2019

Purpose of the study. To analyze the concept of creating patient-oriented medicine, the prerequisites for its emergence, the difficulties of introducing it into existing health systems based on foreign experience. Materials and methods. The main materials of the study were used sources of foreign literature, which presents the concept of patient-oriented medicine, analyzed the prerequisites for changing models of health care in the European Union, USA and Asia in accordance with the principles of patient-oriented medicine, as well as data on the components and levels of patient-oriented medicine in foreign countries Results. The analyzed literature quite fully describes the difficulties of introducing patient-oriented medicine into existing health care systems. Particular attention should be paid to a multidisciplinary approach, continuity at different levels of medical care and effective communication between the physician and the patient towards the integration of this model into clinical practice. The analysis of the availability of medical care in developed countries and its dependence on social status, ethnicity and disease of the patient. Conclusion. Patient-oriented medicine is a new model for planning, implementing and evaluating medical services, which is based on mutually beneficial partnerships between medical workers, patients and their families. Taking into account the current problems of domestic health care, the introduction of the patient-oriented model will significantly improve the quality of medical care provided to the population of our country. Globally, the implementation of the principles of this model is far from complete. In the Russian Federation, targeted work in this direction requires additional scientific research, systematization of available data, and development of new legal documents
EFFECT OF CONNECTIVE INSUFFICIENCY AND SIZES OF MEDIAN HERNIAS ON BEFORE AND POSTOPERATIVE FUNCTION OF THE ABDOMINAL MUSCLE
Authors: Railianu R. I. , Podoliniy G. I. , Marshaluk A. V.
Published: June 2019

The article analyzes the results of electromyography of the abdominal muscles in 189 patients with median postoperative hernia of the anterior abdominal wall of different sizes before and after the combined methods of hernioplasty, including considering the level of connective tissue failure. In the preoperative period, electromyography was performed in 69 (36,6%), after combined hernioplasty, 120 (63,4%) patients. The patients were divided into a group of 161 (85,1%) patients with clinically significant or histologically confirmed connective tissue insufficiency and into a group of 28 (14,9%) patients without it. The distribution of patients in the examination groups was carried out using an original method of assessing the degree of deviation of collagen fibers from the projection of the Langer lines in microscopic specimens of the skin areas excised during the operation and based on the results of a retrospective analysis of case histories with determination of the intraoperative adhesions of the adhesions in the abdominal cavity or hernial sac. In the formed groups, we studied the amplitude, frequency, front and area of electromyograms obtained from the direct and lateral muscles of the anterior abdominal wall. It was found that in patients with median postoperative hernias, mesenchymal dysplasia was the main reason for the decrease in functional activity and the imbalance of forces between the direct and lateral abdominal muscles. Optimal restoration of electroactivity of the abdominal muscles after combined hernioplasty occurred among patients without clinically significant connective tissue insufficiency. When reaching a giant postoperative hernia of gigantic size in patients with a clinically significant level of connective tissue dysplasia, the functioning of the abdominal muscles decreased by 26%, and in patients without it only by 15%. The pathology of collagen in skin grafts excised during surgery was detected in 91,5% of patients with mid-incisional hernias.
Pharmaceutical industry in Russia: problems and prospects of development
Authors: Nezhnikova Ekaterina V. , Maksimchuk Maksim V.
Published: June 2019

The paper analyzes the changes in the Russian pharmaceutical market and discusses the prospects and trends of the Russian pharmaceutical industry. The purpose of the work is to identify the main directions and problems of development and functioning of the pharmaceutical industry of the Russian Federation. Over the past few years, the state has created a strategy for the development of pharmaceuticals, which can bring the industry to a new level. However, existing problems and the lack of an integrated approach hamper the fulfillment of this task. Based on the analysis, the author provides a list of recommendations to improve the efficiency of the functioning and solving the main problems of the pharmaceutical industry, special attention is paid to increasing the investment potential, strengthening the legal framework of the industry, and the importance of increasing the innovative potential of the industry.
Spatial differentiation in the development of territorial systems of public service (an example of Saransk city)
Authors: Semina Irina A.
Published: June 2019

Spatial saturation of a city of consumer product and services leads to the formation of territorial systems of servicing, where service spheres is interacting actively, to complement each other and competing for the consumer. This process covers all of residential area, it differentiats between areas of the city, stands out the centers and complexes of service. They performs only regional function in some urban areas, but there are centers of educational, medical and merchant services citywide and regional significance. It was allocated areas by the nature of the service of the population, security of services, comfort conditions for people’s lives with consideration the complex development social infrastructure and provision of public services in territory of Saransk city. These areas has relatively high complexity of territorial organization of social infrastructure and high endowment the population of services combined with a satisfactory level of comfort of people living conditions; with average complexity of the territorial organization of social infrastructure and high complexity of population services in combination with a low level of comfort of living conditions (influenced by industrial enterprises and highways); with relatively low complexity of territorial organization of social infrastructure and low complexity of population services in combination with a satisfactory level of comfort of living conditions - the private sector of one-story buildings, old buildings. Area has the average complexity of the territorial organization social infrastructure and average endowment of the population services in combination with a satisfactory level of comfort of living conditions for residential peripheral districts of Saransk city. The average complexity of the territorial organization social infrastructure and average endowment of population services in combination with a low level of comfort of living conditions determines to the districts remote from the centre of the city and located in the former industrial plants. The existence of these areas confirms concentric development model spatial structure of Saransk city.
External and internal barriers to innovation in the oil and gas complex of Russia
Authors: Korenevskaya Anna V.
Published: June 2019

The article deals with the external and internal barriers and the results of the impact of such restrictions on the development of the innovation process in the oil and gas complex of Russia, as well as an objective assessment of the current situation in the field of innovations in the oil and gas industry. The aim of the study is to analyze the current barriers and opportunities to overcome them on the way to unlocking the potential of Russian import substitution programs, as well as the introduction of new technologies in the oil and gas industries. The study is based on the hypothesis that process innovations in the oil and gas sector have an obvious impact not only on the final results of specific companies in the industry, but also on the overall state of the national economy. Today we can observe the process of transition of the Russian economy to an innovative way of development. Such a transformation is of great importance for the further development of the country, and the strategic directions of transition to an innovative type of economic development were identified in the Concept of long-term socio-economic development in 2020. One of the long-term goals was to increase the share of innovation in the economic growth of the Russian Federation. The process of innovation in enterprises is usually long-term and involves some barriers that require systematization and substantive consideration. Thus, the article assesses the potential economic damage from the existing barriers to the innovative development of the oil and gas sector. The analysis of the sanctions pressure of Western countries on the Russian oil and gas complex companies and the effect of sanctions restrictions in the long term. The scientific base of the work is based on the data of state statistics, analytical data of fuel and energy complex companies, foreign sources, as well as on the assessments of independent experts.
Service sector (services) key features of Russia and Azerbaijan
Authors: Savlov Mikhail E.
Published: June 2019

The presented article gives a general description of the sphere of non-material production of Russia and Azerbaijan, which is based on the key macroeconomic indicators. The internal heterogeneous structure of the sector is also illustrated, structural features of the service sector and its individual segments in both countries are revealed. The objectivity and adequacy of the sphere characteristics of non-material production of Russia and Azerbaijan is based on intercountry comparisons. Macroeconomic indicators of main developed countries (the USA, Japan, Germany, France, the United Kingdom), the BRICS countries and the former Soviet republics serve as a background for the illustration of the service sectors of Russia and Azerbaijan. It is too early to refer Russia and Azerbaijan to post-industrial countries, even considering only one economic parameter - the structure of the economy. Considering the gross value added (GVA) of the service sector per capita in current prices and the GVA of the service sector per capita in constant 2010 prices, Russia and Azerbaijan lag behind the leading economies of the world, some BRICS countries and even some former republics of USSR. In this regard, the study of the sphere of intangible production is not so popular in Russia and Azerbaijan, as the economic background for the actualization of these studies has not been yet created.
ENGLISH AS A MEDIUM OF INSTRUCTION IN INDONESIAN PRIMARY AND SECONDARY EDUCATION: Theory and reality
Authors: Khasbani Imam
Published: June 2019

The globalization phenomenon marked by the flow of people movements, the advancement of informational technology, and the shrinking price of transportation has brought people around the world into one global community. Comprised by people from diverse linguistic backgrounds, this community sees the need to use a common language to bridge the communication gap. With a long-established economic and political power, English comes to the forefront as a global lingua franca. With its growing and pervasive influence, the need to learn English has never become more apparent. This need is often translated by government into language-in-education policy. This paper, to start with, will observe how language policy and globalization build a causal relationship. In the section that follows, language-in-education policy in Indonesian context will be presented. The following part will move on to discuss the use of EMI in Sekolah Berstandar Internasional (SBI)-International Standard School in Indonesia. In the end, a reflection and conclusion of EMI in Indonesia context will be discussed. In doing so, this paper employs literature study approach to explore the EMI practice in Indonesian schools. All relevant information was collected from several sources such as books and journal articles. The information was then utilised to build on discussions on existing theoretical framings, language policy and globalization, and on language-in-education policy and practice in Indonesia.
Association of Baseline Hyperglycemia With Outcomes of Patients With and Without Diabetes With Acute Ischemic Stroke Treated With Intravenous Thrombolysis: A Propensity Score–Matched Analysis From the SITS-ISTR Registry
Authors: Tsivgoulis Georgios , Katsanos Aristeidis H. , Mavridis Dimitris , Lambadiari Vaia , Roffe Christine , Macleod Mary Joan , Sevcik Petr , Cappellari Manuel , Nevšímalová Miroslava , Toni Danilo , Ahmed Niaz
Published: June 2019

Available data from observational studies on the association of admission hyperglycemia (aHG) with outcomes of patients with acute ischemic stroke (AIS) treated with intravenous thrombolysis (IVT) are contradictory, especially when stratified by diabetes mellitus (DM) history. We assessed the association of aHG (≥144 mg/dL) with outcomes stratified by DM history using propensity score–matched (PSM) data from the SITS-ISTR. The primary safety outcome was symptomatic intracranial hemorrhage (SICH); 3-month functional independence (FI) (modified Rankin Scale [mRS] scores 0–2) represented the primary efficacy outcome. Patients with and without aHG did not differ in baseline characteristics both in the non-DM (n = 12,318) and DM (n = 6,572) PSM subgroups. In the non-DM group, patients with aHG had lower 3-month FI rates (53.3% vs. 57.9%, P < 0.001), higher 3-month mortality rates (19.2% vs. 16.0%, P < 0.001), and similar symptomatic intracerebral hemorrhage (SICH) rates (1.7% vs. 1.8%, P = 0.563) compared with patients without aHG. Similarly, in the DM group, patients with aHG had lower rates of 3-month favorable functional outcome (mRS scores 0–1, 34.1% vs. 39.3%, P < 0.001) and FI (48.2% vs. 52.5%, P < 0.001), higher 3-month mortality rates (23.7% vs. 19.9%, P < 0.001), and similar SICH rates (2.2% vs. 2.7%, P = 0.224) compared with patients without aHG. In conclusion, aHG was associated with unfavorable 3-month clinical outcomes in patients with and without DM and AIS treated with IVT.
Statsvitenskapelige blindsoner: Iver Neumann i et faglig perspektiv
Authors: Bratberg Øivind
Published: June 2019

Iver Neumann has been an inter-disciplinary entrepreneur for political science in Norway. For Neumann, interdisciplinarity has been coupled with an understanding of politics as the search for meaning and identity. These features are well-developed in European political science, particularly within the field of international relations, but they are more rarely encountered in Norway. This brief article provides a sketch of political science as it evolved and matured in its Norwegian incarnation. In situating Iver Neumann within the discipline, I emphasise his international and eclectic orientation. The personal, national and international meet in Neumann’s works, as do popular culture and politics.
Strategic Challenges in the Baltic Sea Region: Russia, Deterrence and Reassurance
Authors: Neretnieks Karlis
Published: June 2019

Vill man få en uppfattning om de säkerhetspolitiska utmaningarna i Östersjöområdet bör man ta del av denna mycket läsvärda antologi som i tolv korta uppsatser analyserar ett antal centrala faktorer som påverkar säkerheten i regionen. Det är en imponerande samling experter som redaktören för boken, Ann-Sofie Dahl, lyckats få till att medverka. Tyvärr medger inte utrymmet här att kommentera samtligas bidrag, det hade de förtjänat. Alla har på ett stringent och lättbegripligt sätt lyckats lyfta fram de sannolikt avgörande frågorna inom de områden som de avhandlat.