bluuebunny/crossref_metadata_2025 huggingface dataset:
The Association of Planetary Health Diet with the Risk of Type 2 Diabetes and Related Complications: A Systematic Review
Authors: Ojo Omorogieva , Jiang Yiqing , Ojo Osarhumwese Osaretin , Wang Xiaohua
Published: April 2023

Background: Nutritional interventions such as the planetary health diet, which the EAT-Lancet commission proposed, may be an effective strategy for reducing type 2 diabetes risks and its associated complications. The planetary health diet demonstrates the significant role of diet in associating human health with environmental sustainability and the significance of transforming food systems in order to ensure that the UN’s Sustainable Development Goals and the Paris Agreement are achieved. Therefore, the aim of this review is to examine the association of the planetary health diet (PHD) with the risk of type 2 diabetes and its related complications. Method: The systematic review was conducted in line with established guidelines. The searches were carried out in health sciences research databases through EBSCOHost. The population, intervention, comparator and outcomes framework was used in order to define the research question and the search terms. The searches were carried out from the inception of the databases to 15 November 2022. Search terms including synonyms and medical subject headings were combined using Boolean operators (OR/AND). Results: Seven studies were included in the review and four themes were identified, including incidence of diabetes; cardiovascular risk factors and other disease risks; indicators of obesity and indicators of environmental sustainability. Two studies examined the association between the PHD and the incidence of type 2 diabetes and found that high adherence to the reference diet (EAT-Lancet reference diet) was correlated with a lower incidence of type 2 diabetes. High adherence to the PHD was also associated with some cardiovascular risk factors and environmental sustainability. Conclusion: This systematic review has shown that high adherence to the PHD is associated with a reduced risk of type 2 diabetes and may be associated with a lower risk of subarachnoid stroke. In addition, an inverse relationship was found between adherence to the PHD and markers of obesity and environmental sustainability. Adherence to the reference diet was also associated with lower values of some markers of cardiovascular risk. More studies are needed to fully examine the relationship between the planetary health diet, type 2 diabetes and its related conditions.
Effectiveness of the Patient’s Severity Classification Competency Promotion Virtual Reality Program of Nursing Students during the COVID-19 Pandemic Period
Authors: Lee Eunju , Baek Gyuli , Hwang Yeonhui
Published: April 2023

The purpose of this study was to develop a virtual reality-based nursing education program aimed at improving nursing students’ severity classification competency. Severity classification in the emergency room is key to improving the efficiency of emergency room services worldwide. Prioritizing treatment based on correctly identifying the severity of a disease or an injury also ensures patients’ safety. The five actual clinical scenarios in the program helped to promptly classify patients into five clinical situations based on the 2021 Korean Emergency Patient Classification Tool. Seventeen nursing students were in an experimental group that had access to a virtual reality-based simulation combined with clinical practice. Seventeen nursing students were in a control group that only participated in routine clinical practice. The virtual reality-based nursing education program effectively improved students’ severity classification competency, performance confidence, and clinical decision-making ability. Although the pandemic continues, the virtual reality-based nursing education program provides realistic indirect experiences to nursing students in situations where clinical nursing practice is not possible. In particular, it will serve as basic data for the expansion and utilization strategy of virtual reality-based nursing education programs to improve nursing capabilities.
Culturally Tailored Dietary Interventions for Improving Glycaemic Control and Preventing Complications in South Asians with Type 2 Diabetes: Success and Future Implications
Authors: Farhat Grace
Published: April 2023

Glycaemic control is the basis of type 2 diabetes mellitus (T2DM) management and is crucial for preventing diabetes microvascular and macrovascular complications. The South Asian population is at higher risk of T2DM and resultant cardiovascular disease, peripheral vascular disease and death compared to Caucasians. Effective diabetes care has been deemed challenging in this population, but little is known about the usefulness of lifestyle interventions in improving glycaemic control and reducing complications. This narrative review aims to explore the efficacy of lifestyle interventions targeted to South Asians with T2DM in inducing clinically relevant improvements in HbA1c levels at such levels that reduce the risk of diabetes complications. A search of the literature using six databases (MEDLINE (EBSCOhost), PubMed, CINAHL, PsycINFO, Cochrane Central Register of Controlled Trials and Scopus) identified dietary-based, physical-activity-based and education-based interventions that aimed to manage T2DM in South Asians. Results showed that dietary and physical activity interventions (duration 3-12 months) have been effective in generating a clinically relevant decrease in HbA1c levels (≥0.5%) in South Asians with T2DM and could potentially assist in reducing diabetes complications. Education-based interventions produced small effects on glycaemic control. These outcomes support the development of comparable longer-term randomised clinical trials combining dietary and physical activity interventions with the aim to provide further evidence on specific interventions that can lower complications and ensure effective diabetes care in a high-risk population.
The Relationship of Nurse and Physician Staffing in Intensive Care Units with Patient Outcomes in Postoperative Patients on Ventilators: An Analysis Using Korean National Health Insurance Data
Authors: Kim Yunmi , Kim Seon-Ha
Published: April 2023

This study examined the associations of nurse and physician staffing in intensive care units (ICUs) with hospital-acquired pneumonia (HAP) incidence and in-hospital mortality in postoperative patients on ventilators. National Health Insurance claims data and death statistics were used to investigate the nurse staffing level and the presence or absence of a dedicated resident and specialist in each ICU. The participants were patients aged 20–85 who underwent any of 13 surgical procedures and were placed on a ventilator in the ICU after the procedure. Of 11,693 patients, 307 (2.6%) experienced HAP and 1280 (10.9%) died during hospitalization. Compared to hospitals with lower nurse-to-patient ratios, patients in hospitals with higher ratios had statistically significantly higher risks of HAP and in-hospital mortality. The presence of a dedicated resident in the ICU did not statistically significantly affect HAP incidence or in-hospital mortality. The presence of an ICU specialist was statistically significantly associated with in-hospital mortality but not HAP incidence. Our findings suggest that a higher level of nursing staff in the ICU is inversely associated with HAP incidence. The legal standards for nurse staffing in the ICU should be strengthened in order to improve the quality of care and patient safety.
Characteristics Associated with Self-Reported Exercise among US Adults Age ≥50 Years with Self-Reported Pain in the Past Four Weeks Who Used an Opioid
Authors: Axon David R. , Quigg Miles D.
Published: April 2023

The number of older adults in the United States is growing, alongside the number of older adults experiencing some sort of pain and using opioids. Exercise is an important pain management and pain prevention strategy. However, little is known about the factors associated with exercise among United States adults ≥50 years old with pain who use opioids. This retrospective cross-sectional database study aimed to identify characteristics associated with self-reported frequent exercise (moderate- to vigorous-intensity exercise ≥30 min five times a week) in United States adults ≥50 years old with pain in the past four weeks who had also used an opioid. The study used 2020 Medical Expenditure Panel Survey data and logistic regression models. Analyses maintained the structure of the complex survey data and were weighted to obtain nationally representative estimates. Significantly associated variables with frequent exercise in the fully adjusted analysis included being aged 60–69 (versus ≥80 years, adjusted odds ratio [AOR] = 2.3, 95% confidence interval [CI] = [1.1–5.1]), having excellent/very good/good (versus fair/poor) self-perceived health (AOR = 2.4, 95% CI = [1.3–4.2]), normal/underweight (versus obese (AOR = 2.1, 95% CI = [1.1–3.9])), overweight (versus obese (AOR = 1.7, 95% CI = [1.0–2.9])), and having little (versus extreme) pain (AOR = 2.4, 95% CI = [1.0–5.7]). A secondary finding was that 35.7% considered themselves frequent exercisers, while the remaining 64.3% did not consider themselves frequent exercisers. In future, these findings can be used to personalize pain management strategies and encourage greater levels of exercise among this population.
Hyoid Bone Syndrome in a Patient Undergoing Left Ventricular Assist Device Implantation
Authors: Bordoni Bruno , Escher Allan R.
Published: April 2023

The clinical case describes the presence of hyoid bone syndrome (HBS) in a patient with a left ventricular assist device (LVAD) implantation, and the resolution of painful symptoms through an osteopathic manual technique (unwinding) applied to the tongue. To the knowledge of the authors, it is the first case report involving an LVAD patient with HBS treated with an osteopathic approach. The article briefly reviews the data relating to surgical therapy for patients with a clinical history of end-stage heart failure and symptoms related to HBS and posits some hypotheses on the presence of pain radiating from the hyoid bone to other areas of the body. The text reminds us to place greater clinical emphasis on the palpatory evaluation of the hyoid in the presence of non-specific painful symptoms.
Nosocomial Infections Affecting Newborns with Abdominal Wall Defects
Authors: Ţarcă Elena , Cojocaru Elena , Trandafir Laura Mihaela , Melinte Popescu Marian George , Luca Alina Costina , Butnariu Lăcrămioara Ionela , Hanganu Elena , Moscalu Mihaela , Ţarcă Viorel , Stătescu Laura , Radu Iulian , Melinte Popescu Alina Sinziana
Published: April 2023

Abdominal wall defects are serious birth defects, with long periods of hospitalization and significant costs to the medical system. Nosocomial infection (NI) may be an additional risk factor that aggravates the evolution of newborns with such malformations. Methods: in order to analyze the factors that may lead to the occurrence of NI, we performed a retrospective study over a period of thirty-two years (1990–2021), in a tertiary children’s hospital; 302 neonates with omphalocele and gastroschisis were eligible for the study. Results: a total of 33.7 % patients were infected with one or more of species of bacteria or fungi. These species were Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp., Staphylococcus spp., Enterococcus spp. or Candida spp., but the rate of NI showed a significant decrease between the 1990–2010 and 2011–2021 period (p = 0.04). The increase in the number of surgeries was associated with the increase in the number of NI both for omphalocele and gastroschisis; in the case of gastroschisis, the age of over 6 h at the time of surgery increased the risk of infection (p = 0.052, marginal statistical significance). Additionally, for gastroschisis, the risk of NI was 4.56 times higher in the presence of anemia (p < 0.01) and 2.17 times higher for the patients developing acute renal failure (p = 0.02), and a hospitalization period longer than 14 days was found to increase the risk of NI 3.46-fold (p < 0.01); more than 4 days of TPN was found to increase the NI risk 2.37-fold (p = 0.015). Using a logistic regression model for patients with omphalocele, we found an increased risk of NI for those in blood group 0 (OR = 3.8, p = 0.02), in patients with a length of hospitalization (LH) of ≥14 days (OR = 6.7, p < 0.01) and in the presence of anemia (OR = 2.5, p = 0.04); all three independent variables in our model contributed 38.7% to the risk of NI. Conclusion: although in the past 32 years we have seen transformational improvements in the outcome of abdominal wall defects, there are still many factors that require special attention for corrections.
The Effect of Light Intensity and Photoperiod on the Yield and Antioxidant Activity of Beet Microgreens Produced in an Indoor System
Authors: Hernández-Adasme Cristian , Palma-Dias Rayen , Escalona Víctor Hugo
Published: April 2023

Microgreens are immature and tender edible vegetables that have become relevant in the market due to their contribution to human health as “functional food”. They can be produced in controlled environments, allowing more efficient use of space and resources and facilitating the management of environmental conditions, such as light, temperature, and relative humidity. The study’s objective was to evaluate the impact of photoperiod and light intensity on red beet microgreens’ yield and the antioxidant compound content. LED growth lamps (spectrum of 75% red, 23% blue, and 2% far-red) under two photoperiods were evaluated: 12 and 16 h, and three intensity levels: 120 (low), 160 (medium), and 220 (high) µmol m−2 s−1. The largest photoperiod raised 32, 49, and 25% on phenolic compounds, total betalains, and antioxidant capacity, respectively, but a 23% reduction in microgreens yield was obtained compared with the shortest photoperiod. The low and medium intensities promoted the highest yield, reaching 460 g m−2; yield decreased significantly by 22.1% at high intensity compared to low and medium intensity. Contrastingly, no effect on antioxidant activity was observed with the evaluated range intensities, except for the betalains concentration, which was reduced by 35% under the highest intensity compared to low intensity. On the other hand, resource use efficiency (energy and water) improved under the shortest photoperiod. Thus, an intensity between 120 and 160 µmol m−2 s−1 and a photoperiod of 12 h favored the microgreen’s beet growth and saved electricity; meanwhile, a 16 h photoperiod ameliorated the beet microgreens antioxidant activity under a light spectrum composed of blue:red:far-red = 23:75:2.
Effects of Light-Emitting Diodes (LEDs) on Growth, Nitrates and Osmoprotectant Content in Microgreens of Aromatic and Medicinal Plants
Authors: El Haddaji Hamza , Akodad Mustapha , Skalli Ali , Moumen Abdelmajid , Bellahcen Said , Elhani Sliman , Urrestarazu Miguel , Kolar Mitja , Imperl Jernej , Petrova Petranka , Baghour Mourad
Published: April 2023

Microgreens are receiving increasing attention due to their high content of bioactive components and their importance to human health. These emerging food products can be obtained from the seeds of different plant species, including aromatic herbs. Aromatic microgreens are gaining popularity as new functional food products. In this study, we investigated the effects of different light-emitting diode (LED) lamp spectra on the growth, pigments, nitrates, and osmoprotectant content of microgreens of Ocimum basilicum L., Trigonella foenum-graecum, Anethum graveolens, and Anthriscus cerefolium plants. Three types of artificial LED lamps were used: T0 as artificial white light, T1 as a continuous light-emitting diode with a longer blue wavelength, and T2 as a continuous light-emitting diode with a longer red wavelength. The results obtained showed that the three types of LED light had significant effects on the different parameters studied. In relation to growth parameters, such as fresh weight (FW) and microgreen height (H), the T2 treatment was most effective for fenugreek, dill, and chervil. However, in basil plants, FW and H values were higher under T1 treatment. Regarding nitrate accumulation, both T1 and T2 treatments reduced the content of this nutrient in the different species studied here. Finally, levels of chlorophyll, carotenoid, glucose, proline, and proteins were all higher in plants cultivated under T1 and T2 treatments than in control plants.
Evaluation of Hydrogen Blend Stability in Low-Pressure Gas Distribution
Authors: Kileti Pradheep , Barkwill Brian , Spiteri Vincent , Cavanagh Christopher , Mahajan Devinder
Published: April 2023

Natural gas distribution companies are developing ambitious plans to decarbonize the services that they provide in an affordable manner and are accelerating plans for the strategic integration of renewable natural gas and the blending of green hydrogen produced by electrolysis, powered with renewable electricity being developed from large new commitments by states such as New York and Massachusetts. The demonstration and deployment of hydrogen blending have been proposed broadly at 20% of hydrogen by volume. The safe distribution of hydrogen blends in existing networks requires hydrogen blends to exhibit similar behavior as current supplies, which are also mixtures of several hydrocarbons and inert gases. There has been limited research on the properties of blended hydrogen in low-pressure natural gas distribution systems. Current natural gas mixtures are known to be sufficiently stable in terms of a lack of chemical reaction between constituents and to remain homogeneous through compression and distribution. Homogeneous mixtures are required, both to ensure safe operation of customer-owned equipment and for safety operations, such as leak detection. To evaluate the stability of mixtures of hydrogen and natural gas, National Grid experimentally tested a simulated distribution natural gas pipeline with blends containing hydrogen at up to 50% by volume. The pipeline was outfitted with ports to extract samples from the top and bottom of the pipe at intervals of 20 feet. Samples were analyzed for composition, and the effectiveness of odorant was also evaluated. The new results conclusively demonstrate that hydrogen gas mixtures do not significantly separate or react under typical distribution pipeline conditions and gas velocity profiles. In addition, the odorant retained its integrity in the blended gas during the experiments and demonstrated that it remains an effective method of leak detection.
Perceived Stress and Impact on Role Functioning in University Students with Migraine-Like Headaches during COVID-19
Authors: Tamulevicius Nauris , Save Ritika , Gandhi Nishita , Lubiak Sean , Sharma Siddhi , Aguado Loi Claudia X. , Paneru Khyam , Martinasek Mary P.
Published: April 2023

Migraines, a chronic disease, can be debilitating in university students, affecting their academic performance, attendance, and social interactions. The purpose of this study was to identify the impact of COVID-19 on the role functioning and perceived stress levels of students suffering from migraine-like headaches. Methods: Two identical cross-sectional surveys were sent to students in Fall 2019 and Spring 2021 at a mid-sized university in the U.S. The students were queried on the headache impact scale (HIT-6) and perceived stress scale (PSS-10). Associations between the migraine-like headaches, severity of the headaches, stress levels, and headache impacts on the individuals’ role functioning were analyzed. Results: The average age of the respondents (n = 721) was 20.81 ± 4.32 years in 2019 and (n = 520) 20.95 ± 3.19 years in 2021. A difference (p = 0.044) was found in the HIT-6 score <49 category. The other categories of the HIT-6 and the PSS-10 were not significant. Conclusions: During COVID-19, more students answered that their migraine-like headaches had lower impacts on their role functioning, thus suggesting that the students were having less severe migraines. A trend was seen for student’s stress levels, indicating a decrease from 2019 to 2021. Furthermore, our results showed that the impact of headaches and stress levels slightly declined throughout the pandemic.
Psychological Characteristics of Women with Perinatal Depression Who Require Psychiatric Support during Pregnancy or Postpartum: A Cross-Sectional Study
Authors: Terrone Grazia , Bianciardi Emanuela , Fontana Andrea , Pinci Carolina , Castellani Giulia , Sferra Irene , Forastiere Anna , Merlo Mattia , Marinucci Elicio , Rinaldi Fiamma , Falanga Marina , Pucci Daniela , Siracusano Alberto , Niolu Cinzia
Published: April 2023

Antenatal depression may be distinct from postpartum depression in terms of prevalence, severity of symptoms, comorbidities, prognosis, and risk factors. Although risk factors for perinatal depression have been identified, it is unclear whether there are differences in the onset of perinatal depression (PND). This study explored the characteristics of women requiring mental health support during pregnancy or postpartum. A sample of 170 women (58% in pregnancy; 42% postpartum) who contacted the SOS-MAMMA outpatient clinic was recruited. Clinical data sheets and self-report questionnaires (EPDS, LTE-Q, BIG FIVE; ECR; BSQ; STICSA) were administered, hypothesizing possible risk factors, such as personality traits, stressful life events, body dissatisfaction, attachment style, and anxiety. Hierarchical regression models were carried out in the pregnancy (F10;36 = 8.075, p < 0.001, adjR2 = 0.877) and postpartum groups (F10;38 = 3.082, p < 0.05, adjR2 = 0.809). Recent stressful life events and conscientiousness were associated with depression in both the pregnant (29.3%, 25.5% of variance) and postpartum groups (23.8%, 20.7% of variance). In pregnant women, “openness” (11.6%), body dissatisfaction (10.2%), and anxiety (7.1%) symptoms were predictive of depression. In the postpartum group, “neuroticism” (13.8%) and insecure romantic attachment dimensions (13.4%; 9.2%) were the strongest predictors. Perinatal psychological interventions should consider the differences between mothers with depression during pregnancy and postpartum.
Development and Validation of Safe Motherhood-Accessible Resilience Training (SM-ART) Intervention to Improve Perinatal Mental Health
Authors: Bhamani Shireen Shehzad , Arthur David , Van Parys An-Sofie , Letourneau Nicole , Wagnild Gail , Degomme Olivier
Published: April 2023

Perinatal mental health issues in women can lead to a variety of health complications for both mother and child. Building resilience can strengthen coping mechanisms for pregnant women to improve their mental health and protect themselves and their children. The study aims to develop and validate the contextual and cultural appropriateness of the Safe Motherhood-Accessible Resilience Training (SM-ART) intervention for pregnant women in Pakistan. A three-phase approach was used to develop and validate an intervention that promotes resilience in pregnant women. Phase I comprised a needs assessment with stakeholders (pregnant women and key informants) to elicit opinions regarding module content. In Phase II, an intervention to build resilience was developed with the help of a literature review and formative assessment findings, and Phase III involved the validation of the intervention by eight mental health experts. The experts assessed the Content Validity Index (CVI) of the SM-ART intervention on a self-developed checklist. The resultant SM-ART intervention consists of six modules with strong to perfect CVI scores for each of the modules. Qualitative responses endorsed the strengths of the intervention as having innovative and engaging activities, contextual and cultural relevance, and a detailed, comprehensive facilitator guide. SM-ART was successfully developed and validated and is now ready for testing to promote the resilience of pregnant women at risk of perinatal mental illness.
Improving Metabolic Syndrome in Ghanaian Adults with Type 2 Diabetes through a Home-Based Physical Activity Program: A Feasibility Randomised Controlled Trial
Authors: Amin Mohammed , Kerr Debra , Atiase Yacoba , Samir Misbah Muhammad , Driscoll Andrea
Published: April 2023

There is a high prevalence of metabolic syndrome (MetS) among people with type 2 diabetes mellitus (T2DM). Physical activity has the potential to improve health outcomes for individuals with type 2 diabetes. Our study aim was to determine the effect of a 12-week culturally appropriate home-based physical activity program on metabolic syndrome markers and quality of life in Ghanaian adults with T2DM. A secondary objective was to examine the feasibility of implementing the PA program. A feasibility randomised controlled trial (RCT) was conducted. A purposive sample of 87 adults with T2DM at the Korle-Bu Teaching Hospital, Ghana, were randomized into either the control group (CG) (n = 43) or the intervention group (IG) (n = 44). Participants in the IG received the physical activity program in addition to their usual diabetes care; those in the CG received their usual diabetes care. Measurements for feasibility, MetS markers, and quality of life (SF-12) were performed at baseline and 12-week follow-up. Following the 12-week program, participants in the IG showed a significant improvement in fasting blood glucose (2.4% vs. 0.4%, p < 0.05), waist circumference (5.4% vs. 0.4%, p < 0.05), and systolic blood pressure (9.8% vs. 1.5%, p < 0.05). There were no statistical differences between the IG and CG regarding high-density lipoprotein, triglycerides, and diastolic blood pressure at the 12-week follow-up. Classification of MetS were reduced in the IG compared to the CG (51.2% vs. 83.3%, p < 0.05). The MetS severity score improved in the IG compared to the CG (8.8% vs. 0.5%, p < 0.05). The IG improved in two of the eight SF-12 dimensions (physical function and vitality, p < 0.05) compared to the CG. Thirty-two (72.7%) participants completed all 36 exercise sessions. Another 11 (25%) participants completed 80% of the exercise sessions. No adverse events were reported. In conclusion, a 12-week home-based physical activity program is feasible and safe. The intervention has the potential to improve MetS and quality of life in Ghanaian adults with T2DM. The preliminary findings of this study need to be confirmed in a large-scale multi-centre RCT.
Security Risks and User Perception towards Adopting Wearable Internet of Medical Things
Authors: Thapa Sanjit , Bello Abubakar , Maurushat Alana , Farid Farnaz
Published: April 2023

The Wearable Internet of Medical Things (WIoMT) is a collective term for all wearable medical devices connected to the internet to facilitate the collection and sharing of health data such as blood pressure, heart rate, oxygen level, and more. Standard wearable devices include smartwatches and fitness bands. This evolving phenomenon due to the IoT has become prevalent in managing health and poses severe security and privacy risks to personal information. For better implementation, performance, adoption, and secured wearable medical devices, observing users’ perception is crucial. This study examined users’ perspectives of trust in the WIoMT while also exploring the associated security risks. Data analysed from 189 participants indicated a significant variance (R2 = 0.553) on intention to use WIoMT devices, which was determined by the significant predictors (95% Confidence Interval; p < 0.05) perceived usefulness, perceived ease of use, and perceived security and privacy. These were found to have important consequences, with WIoMT users intending to use the devices based on the trust factors of usefulness, easy to use, and security and privacy features. Further outcomes of the study identified how users’ security matters while adopting the WIoMT and provided implications for the healthcare industry to ensure regulated devices that secure confidential data.
No Excess of Mortality from Lung Cancer during the COVID-19 Pandemic in an Area at Environmental Risk: Results of an Explorative Analysis
Authors: Addabbo Francesco , Giotta Massimo , Mincuzzi Antonia , Minerba Aldo Sante , Prato Rosa , Fortunato Francesca , Bartolomeo Nicola , Trerotoli Paolo
Published: April 2023

Background: The COVID-19 pandemic and the restrictive measures associated with it placed enormous pressure on health facilities and may have caused delays in the treatment of other diseases, leading to increases in mortality compared to the expected rates. Areas with high levels of air pollution already have a high risk of death from cancer, so we aimed to evaluate the possible indirect effects of the pandemic on mortality from lung cancer compared to the pre-pandemic period in the province of Taranto, a polluted site of national interest for environmental risk in the south of Italy. Methods: We carried out a retrospective observational study on lung cancer data (ICD-10: C34) from the Registry of Mortality (ReMo) for municipalities in Taranto Province over the period of 1 January 2011 to 31 December 2021. Seasonal exponential smoothing, Holt–Winters additive, Holt–Winters multiplicative, and auto-regressive integrated moving average (ARIMA) models were used to forecast the number of deaths during the pandemic period. Data were standardized by sex and age via an indirect method and shown as monthly mortality rates (MRs), standardized mortality ratios (SMRs), and adjusted mortality rates (AMRs). Results: In Taranto Province, 3108 deaths from lung cancer were recorded between 2011 and 2021. In the province of Taranto, almost all of the adjusted monthly mortality rates during the pandemic were within the confidence interval of the predicted rates, with the exception of significant excesses in March (+1.82, 95% CI 0.11–3.08) and August 2020 (+2.09, 95% CI 0.20–3.44). In the municipality of Taranto, the only significant excess rate was in August 2020 (+3.51, 95% CI 0.33–6.69). However, in total, in 2020 and 2021, the excess deaths from lung cancer were not significant both for the province of Taranto (+30 (95% CI −77; +106) for 2020 and +28 (95% CI −130; +133) for 2021) and for the municipality of Taranto alone (+14 (95% CI −47; +74) for 2020 and −2 (95% CI −86; +76) for 2021). Conclusions: This study shows that there was no excess mortality from lung cancer as a result of the COVID-19 pandemic in the province of Taranto. The strategies applied by the local oncological services during the pandemic were probably effective in minimizing the possible interruption of cancer treatment. Strategies for accessing care in future health emergencies should take into account the results of continuous monitoring of disease trends.
Migrant Women in Shantytowns in Southern Spain: A Qualitative Study
Authors: Plaza del Pino Fernando Jesús , Muñoz Lucena Lucía , Azougagh Nadia , Gómez Haro Ana , Álvarez Puga Belén , Navarro-Prado Silvia , Cabezón-Fernández María Jesús
Published: April 2023

The increase in intensive agriculture in Southern Spain, and the increasing need for migrant women, has led to the appearance of numerous shantytowns alongside greenhouses. In the last few years, the number of women who live in them has increased. This qualitative study delves into the experiences and future expectations of migrant women who live in shantytowns. Thirteen women who live in shantytowns in Southern Spain were interviewed. Results: Four themes emerged: dreams vs. reality, life in the settlements, worse for women, and “the papers”. Discussion and Conclusions. Priority should be given to the care of women who live in shantytowns with specific programs; society must work to end these shantytowns and facilitate agricultural workers with access to housing; it is necessary to allow the resident registration of the people who live in shantytowns.
Experiences of Sexual Harassment by Patients among Nurses at the Mental Hospital of West Java Province: A Qualitative Study
Authors: Yosep Iyus , Hikmat Rohman , Suryani Suryani , Mardhiyah Ai
Published: April 2023

Sexual harassment is behavior related to forced sex without the consent of the victim. Incidents of sexual harassment on nurses can be in the form of physical behavior and verbal behavior. The factor of power relations between men and women and the patriarchal culture in Indonesia are the causes of the sexual harassment of mental health nurses, so many incidents of the sexual harassment of women occur. The forms of sexual harassment that occur include kissing, hugging from behind, and verbal abuse related to sex. The purpose of this study was to explore the experience of sexual harassment of psychiatric nurses at the Mental Hospital of West Java Province. This study implemented a qualitative descriptive approach using the NVIVO 12 software application. The sample in this study was 40 psychiatric nurses at the Mental Hospital of West Java Province. The sampling technique in this study was focus group discussions with semi-structured and in-depth interviews. The data analysis in this study used a thematic analysis. This study shows that sexual harassment behavior is carried out by patients in physical and verbal forms. Sexual harassment is mostly carried out by male patients towards female nurses. Meanwhile, sexual harassment took the form of hugging from behind, kissing, naked patients in front of nurses, and disturbing nurses with verbal abuse related to sex. Nurses feel disturbed, afraid, anxious, and shocked by the incidents of sexual harassment committed by patients. Sexual harassment by patients towards nurses causes psychological problems for nurses and causes nurses to want to leave their jobs. Gender adjustment between nurses and patients is a preventive effort to prevent the sexual harassment of nurses. Sexual harassment by patients causes a decrease in the quality of work of nurses in providing nursing care, creating a work environment that is less safe and comfortable.
Identification and Spatiotemporal Analysis of Bikesharing-Metro Integration Cycling
Authors: Wu Hao , Wang Yanhui , Sun Yuqing , Yin Duoduo , Li Zhanxing , Luo Xiaoyue
Published: April 2023

An essential function of dockless bikesharing (DBs) is to serve as a feeder mode to the metro. Optimizing the integration between DBs and the metro is of great significance for improving metro travel efficiency. However, the research on DBs–Metro Integration Cycling (DBsMIC) faces challenges such as insufficient methods for identification and low identification accuracy. In this study, we improve the enhanced two-step floating catchment area and incorporate Bayes’ rule to propose a method to identify DBsMIC by considering the parameters of time, distance, environmental competition ratio, and POI service power index. Furthermore, an empirical study is conducted in Shenzhen to verify the higher accuracy of the proposed method. Their spatiotemporal behavior pattern is also explored with the help of the kernel density estimation method. The research results will help managers improve the effective redistribution of bicycles, promote the coupling efficiency between transportation modes, and achieve sustainable development of urban transportation.
A Semi-Automatic Semantic-Model-Based Comparison Workflow for Archaeological Features on Roman Ceramics
Authors: Thiery Florian , Veller Jonas , Raddatz Laura , Rokohl Louise , Boochs Frank , Mees Allard W.
Published: April 2023

In this paper, we introduce applications of Artificial Intelligence techniques, such as Decision Trees and Semantic Reasoning, for semi-automatic and semantic-model-based decision-making for archaeological feature comparisons. This paper uses the example of Roman African Red Slip Ware (ARS) and the collection of ARS at the LEIZA archaeological research institute. The main challenge is to create a Digital Twin of the ARS objects and artefacts using geometric capturing and semantic modelling of archaeological information. Moreover, the individualisation and comparison of features (appliqués), along with their visualisation, extraction, and rectification, results in a strategy and application for comparison of these features using both geometrical and archaeological aspects with a comprehensible rule set. This method of a semi-automatic semantic model-based comparison workflow for archaeological features on Roman ceramics is showcased, discussed, and concluded in three use cases: woman and boy, human–horse hybrid, and bears with local twists and shifts.
Quality Assessment of Global Ocean Island Datasets
Authors: Chen Yijun , Zhao Shenxin , Zhang Lihua , Zhou Qi
Published: April 2023

Ocean Island data are essential to the conservation and management of islands and coastal ecosystems, and have also been adopted by the United Nations as a sustainable development goal (SDG 14). Currently, two categories of island datasets, i.e., global shoreline vector (GSV) and OpenStreetMap (OSM), are freely available on a global scale. However, few studies have focused on accessing and comparing the data quality of these two datasets, which is the main purpose of our study. Specifically, these two datasets were accessed using four 100 × 100 (km2) study areas, in terms of three aspects of measures, i.e., accuracy (including overall accuracy (OA), precision, recall and F1), completeness (including area completeness and count completeness) and shape complexity. The results showed that: (1) Both the two datasets perform well in terms of the OA (98% or above) and F1 (0.9 or above); the OSM dataset performs better in terms of precision, but the GSV dataset performs better in terms of recall. (2) The area completeness is almost 100%, but the count completeness is much higher than 100%, indicating the total areas of the two datasets are almost the same, but there are many more islands in the OSM dataset. (3) In most cases, the fractal dimension of the OSM dataset is relatively larger than the GSV dataset in terms of the shape complexity, indicating that the OSM dataset has more detail in terms of the island boundary or coastline. We concluded that both of the datasets (GSV and OSM) are effective for island mapping, but the OSM dataset can identify more small islands and has more detail.
Image Retrieval Method Based on Visual Map Pre-Sampling Construction in Indoor Positioning
Authors: Bai Jianan , Qin Danyang , Zheng Ping , Ma Lin
Published: April 2023

In visual indoor positioning systems, the method of constructing a visual map by point-by-point sampling is widely used due to its characteristics of clear static images and simple coordinate calculation. However, too small a sampling interval will cause image redundancy, while too large a sampling interval will lead to the absence of any scene images, which will result in worse positioning efficiency and inferior positioning accuracy. As a result, this paper proposed a visual map construction method based on pre-sampled image features matching, according to the epipolar geometry of adjacent position images, to determine the optimal sampling spacing within the constraints and effectively control the database size while ensuring the integrity of the image information. In addition, in order to realize the rapid retrieval of the visual map and reduce the positioning error caused by the time overhead, an image retrieval method based on deep hashing was also designed in this paper. This method used a convolutional neural network to extract image features to construct the semantic similarity structure to guide the generation of hash code. Based on the log-cosh function, this paper proposed a loss function whose function curve was smooth and not affected by outliers, and then integrated it into the deep network to optimize parameters, for fast and accurate image retrieval. Experiments on the FLICKR25K dataset and the visual map proved that the method proposed in this paper could achieve sub-second image retrieval with guaranteed accuracy, thereby demonstrating its promising performance.
Immunophenotyping of Monocyte Migration Markers and Therapeutic Effects of Selenium on IL-6 and IL-1β Cytokine Axes of Blood Mononuclear Cells in Preoperative and Postoperative Coronary Artery Disease Patients
Authors: Wacker Max , Ball Anna , Beer Hans-Dietmar , Schmitz Ingo , Borucki Katrin , Azizzadeh Faranak , Scherner Maximilian , Awad George , Wippermann Jens , Veluswamy Priya
Published: April 2023

Multivessel coronary artery disease (CAD) is characterized by underlying chronic vascular inflammation and occlusion in the coronary arteries, where these patients undergo coronary artery bypass grafting (CABG). Since post-cardiotomy inflammation is a well known phenomenon after CABG, attenuation of this inflammation is required to reduce perioperative morbidity and mortality. In this study, we aimed to phenotype circulating frequencies and intensities of monocyte subsets and monocyte migration markers, respectively, and to investigate the plasma level of inflammatory cytokines and chemokines between preoperative and postoperative CAD patients and later, to intervene the inflammation with sodium selenite. We found a higher amplitude of inflammation, postoperatively, in terms of CCR1high monocytes and significantly increased pro-inflammatory cytokines, IL-6, IL-8, and IL-1RA. Further, in vitro intervention with selenium displayed mitigating effects on the IL-6/STAT-3 axis of mononuclear cells derived from postoperative CAD patients. In addition, in vitro selenium intervention significantly reduced IL-1β production as well as decreased cleaved caspase-1 (p20) activity by preoperative (when stimulated) as well as postoperative CAD mononuclear cells. Though TNF-α exhibited a positive correlation with blood troponin levels in postoperative CAD patients, there was no obvious effect of selenium on the TNF-α/NF-κB axis. In conclusion, anti-inflammatory selenium might be utilized to impede systemic inflammatory cytokine axes to circumvent aggravating atherosclerosis and further damage to the autologous bypass grafts during the post-surgical period.
Gut-to-Brain α-Synuclein Transmission in Parkinson’s Disease: Evidence for Prion-like Mechanisms
Authors: Chen Merry , Mor Danielle E.
Published: April 2023

Parkinson’s disease (PD) is a multifactorial disorder involving both motor and non-motor symptoms caused by the progressive death of distinct neuronal populations, including dopaminergic neurons in the substantia nigra. The deposition of aggregated α-synuclein protein into Lewy body inclusions is a hallmark of the disorder, and α-synuclein pathology has been found in the enteric nervous system (ENS) of PD patients up to two decades prior to diagnosis. In combination with the high occurrence of gastrointestinal dysfunction in early stages of PD, current evidence strongly suggests that some forms of PD may originate in the gut. In this review, we discuss human studies that support ENS Lewy pathology as a characteristic feature of PD, and present evidence from humans and animal model systems that α-synuclein aggregation may follow a prion-like spreading cascade from enteric neurons, through the vagal nerve, and into the brain. Given the accessibility of the human gut to pharmacologic and dietary interventions, therapeutic strategies aimed at reducing pathological α-synuclein in the gastrointestinal tract hold significant promise for PD treatment.
NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity
Authors: Santharam Madanraj Appiya , Shukla Akhil , Levesque Dominique , Kufer Thomas A. , Boisvert François-Michel , Ramanathan Sheela , Ilangumaran Subburaj
Published: April 2023

Aggressive tumors evade cytotoxic T lymphocytes by suppressing MHC class-I (MHC-I) expression that also compromises tumor responsiveness to immunotherapy. MHC-I defects strongly correlate to defective expression of NLRC5, the transcriptional activator of MHC-I and antigen processing genes. In poorly immunogenic B16 melanoma cells, restoring NLRC5 expression induces MHC-I and elicits antitumor immunity, raising the possibility of using NLRC5 for tumor immunotherapy. As the clinical application of NLRC5 is constrained by its large size, we examined whether a smaller NLRC5-CIITA fusion protein, dubbed NLRC5-superactivator (NLRC5-SA) as it retains the ability to induce MHC-I, could be used for tumor growth control. We show that stable NLRC5-SA expression in mouse and human cancer cells upregulates MHC-I expression. B16 melanoma and EL4 lymphoma tumors expressing NLRC5-SA are controlled as efficiently as those expressing full-length NLRC5 (NLRC5-FL). Comparison of MHC-I-associated peptides (MAPs) eluted from EL4 cells expressing NLRC5-FL or NLRC5-SA and analyzed by mass spectrometry revealed that both NLRC5 constructs expanded the MAP repertoire, which showed considerable overlap but also included a substantial proportion of distinct peptides. Thus, we propose that NLRC5-SA, with its ability to increase tumor immunogenicity and promote tumor growth control, could overcome the limitations of NLRC5-FL for translational immunotherapy applications.
A Mixture Method for Robust Detection HCV Early Diagnosis Biomarker with ML Approach and Molecular Docking
Authors: Gholizadeh Maryam , Łapczuk-Romańska Joanna , Post Mariola , Komaniecka Nina , Mazlooman Seyed Reza , Kaderali Lars , Droździk Marek
Published: April 2023

Given the substantial correlation between early diagnosis and prolonged patient survival in HCV patients, it is vital to identify a reliable and accessible biomarker. The purpose of this research was to identify accurate miRNA biomarkers to aid in the early diagnosis of HCV and to identify key target genes for anti-hepatic fibrosis therapeutics. The expression of 188 miRNAs in 42 HCV liver patients with different functional states and 23 normal livers were determined using RT-qPCR. After screening out differentially expressed miRNA (DEmiRNAs), the target genes were predicted. To validate target genes, an HCV microarray dataset was subjected to five machine learning algorithms (Random Forest, Adaboost, Bagging, Boosting, XGBoost) and then, based on the best model, importance features were selected. After identification of hub target genes, to evaluate the potency of compounds that might hit key hub target genes, molecular docking was performed. According to our data, eight DEmiRNAs are associated with early stage and eight DEmiRNAs are linked to a deterioration in liver function and an increase in HCV severity. In the validation phase of target genes, model evaluation revealed that XGBoost (AUC = 0.978) outperformed the other machine learning algorithms. The results of the maximal clique centrality algorithm determined that CDK1 is a hub target gene, which can be hinted at by hsa-miR-335, hsa-miR-140, hsa-miR-152, and hsa-miR-195. Because viral proteins boost CDK1 activation for cell mitosis, pharmacological inhibition may have anti-HCV therapeutic promise. The strong affinity binding of paeoniflorin (−6.32 kcal/mol) and diosmin (−6.01 kcal/mol) with CDK1 was demonstrated by molecular docking, which may result in attractive anti-HCV compounds. The findings of this study may provide significant evidence, in the context of the miRNA biomarkers, for early-stage HCV diagnosis. In addition, recognized hub target genes and small molecules with high binding affinity may constitute a novel set of therapeutic targets for HCV.