bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-term follow-up of donor-derived CD7 CAR T-cell therapy in patients with T-cell acute lymphoblastic leukemia
Authors: Tan Yue , Shan Lingling , Zhao Liping , Deng Biping , Ling Zhuojun , Zhang Yanlei , Peng Shuixiu , Xu Jinlong , Duan Jiajia , Wang Zelin , Yu Xinjian , Zheng Qinlong , Xu Xiuwen , Tian Zhenglong , Zhang Yibing , Zhang Jiecheng , Chang Alex H. , Feng Xiaoming , Pan Jing
Published: April 2023

Background

Donor-derived CD7-directed chimeric antigen receptor (CAR) T cells showed feasibility and early efficacy in patients with refractory or relapsed T-cell acute lymphoblastic leukemia (r/r T-ALL), in a previous phase I trial report, at a median follow-up of 6.3 months. Here we report long-term safety and activity of the therapy after a 2-year follow-up.

Methods

Participants received CD7-directed CAR T cells derived from prior stem cell transplantation (SCT) donors or from HLA-matched new donors after lymphodepletion. The target dose was 1 × 106 (± 30%) CAR T cells per kg of patient weight. The primary endpoint was safety with efficacy secondary. This report focuses on the long-term follow-up and discusses them in the context of previously reported early outcomes.

Results

Twenty participants were enrolled and received infusion with CD7 CAR T cells. After a median follow-up time of 27.0 (range, 24.0–29.3) months, the overall response rate and complete response rate were 95% (19/20 patients) and 85% (17/20 patients), respectively, and 35% (7/20) of patients proceeded to SCT. Six patients experienced disease relapse with a median time-to-relapse of 6 (range, 4.0–10.9) months, and 4 of these 6 patients were found to have lost CD7 expression on tumor cells. Progression-free survival (PFS) and overall survival (OS) rates 24 months after treatment were respectively 36.8% (95% CI, 13.8–59.8%) and 42.3% (95% CI, 18.8–65.8%), with median PFS and OS of respectively 11.0 (95% CI, 6.7–12.5) months and 18.3 (95% CI, 12.5–20.8) months. Previously reported short-term adverse events (< 30 days after treatment) included grade 3–4 cytokine release syndrome (CRS; 10%) and grade 1–2 graft-versus-host disease (GVHD; 60%). Serious adverse events reported > 30 days after treatment included five infections and one grade 4 intestinal GVHD. Despite good CD7 CAR T-cell persistence, non-CAR T and natural killer cells were predominantly CD7-negative and eventually returned to normal levels in about half of the participants.

Conclusions

In this 2-year follow-up analysis, donor-derived CD7 CAR T-cell treatment demonstrated durable efficacy in a subset of patients with r/r T-ALL. Disease relapse was the main cause of treatment failure, and severe infection was a noteworthy late-onset adverse event.

Trial registration

ChiCTR2000034762.
Nonnegative nontrivial solutions for a class of $p(x)$-Kirchhoff equation involving concave-convex nonlinearities
Authors: Chu Changmu , He Zhongju
Published: April 2023

In this paper, we study the existence of a class of $p(x)$
p
(
x
)
-Kirchhoff equation involving concave-convex nonlinearities. The main tools used are the perturbation technique, variational method, and a priori estimation.
Rescue therapy for local tumor progression after radiofrequency ablation of small hepatocellular carcinoma: a comparison between repeated ablation and transcatheter arterial chemoembolization
Authors: Cha Dong Ik , Lee Min Woo , Ahn Soo Hyun , Song Kyoung Doo , Kang Tae Wook , Sinn Dong Hyun , Rhim Hyunchul
Published: April 2023

Objective:

To compare the therapeutic outcomes of repeated radiofrequency ablation (RFA) and transcatheter arterial chemoembolization (TACE) as rescue therapy for the treatment of local tumor progression (LTP) after initial RFA for hepatocellular carcinoma (HCC).

Methods:

This retrospective study evaluated 44 patients who had LTP as initial tumor recurrence after RFA and underwent repeated RFA (n = 23) or TACE (n = 21) for local disease control. Local disease control and overall survival rates were evaluated using the Kaplan–Meier method. A Cox proportional-hazards regression model was used to identify the independent prognostic factors. The local disease control rate after the first rescue therapy and the number of rescue therapies applied until the last follow-up were also evaluated.

Results:

Local disease control after rescue therapy for LTP was significantly higher with repeated RFA than with TACE (p < 0.001). Treatment type was a significant factor for local disease control (p < 0.001). The overall survival rates after rescue therapy were not significantly different between the two treatments (p = 0.900). The local disease control rate after the first rescue therapy was significantly higher with RFA than with TACE (78.3% vs 23.8%, p < 0.001). The total number of rescue therapies applied was significantly higher in the TACE group than that in the repeated RFA group (median 3 vs 1, p < 0.001).

Conclusion:

Repeated RFA as rescue therapy for LTP after initial RFA for HCC was more efficient and had significantly better local disease control than TACE.

Advances in knowledge:

Even if LTP occurs after initial RFA, it should not be considered a failure of RFA, and repeated RFA should be performed over TACE if possible for more effective local disease control.
Oral hygiene as a cardiovascular risk factor - review of the literature
Authors: Chiżyński Adam , Łęgocka Weronika , Andryszczak Paweł
Published: April 2023

Introduction and Objective. Cardiovascular diseases are the main cause of death in Poland and around the world. An important aspect of managing patients with cardiovascular diseases is their proper diagnosis and treatment. An important element is also the prevention of cardiovascular diseases. Prevention of the occurrence of cardiovascular diseases mentioned above consists of the elimination of so-called cardiovascular risk factors. A relatively unknown risk factor for cardiovascular disease is the lack of oral hygiene. The authors of the work analyze what elements are related to the lack of oral hygiene affect the cardiovascular risk and try to present the mechanisms of the oral cavity condition that may affect the cardiovascular system.

Review Methods. A review of the recent literature was conducted using PubMed, Google Scholar databases.

Brief description of the state of knowledge. The oral cavity is a site colonised by many  species of microorganisms.Bacteria from periodontal pockets can travel to other systems as well as enter the bloodstream, and that way to distant organs. A normal endocardial endothelium provides a barrier for bacteria and prevents colonisation and the development of inflammation. However, in cases where it is damaged, it can provide a gateway for microorganisms to infect the valve, which may lead to the development of infective endocarditis.

Summary.  In case of periodontitis in patient with ischemic heart disease, myocardial infarction or stroke, active dental or periodontal treatment should be undertaken. Bacteria from periodontal pockets can travel to other systems causing pathological changes in them.

Key words

Oral hygiene, periodontitis, infective endocarditis
W kręgu mitów, czyli o tym, co nie zadecydowało o wyborze Augusta II na tron polski w 1697 roku
Authors: Kosińska Urszula
Published: April 2023

Polskie elekcje wciąż budzą zainteresowanie, a ta z 1697 r. wyróżnia się liczbą przekazów i opracowań. Opisom towarzyszy wyjątkowo zła opinia o poziomie obyczajów polskiej szlachty i jej politycznego wyrobienia, co rzutuje też negatywnie na postrzeganie elekcji jako elementu ustrojowego Rzeczypospolitej. Celem artykułu jest sfalsyfikowanie dotychczasowych sądów historiografii, jakoby w 1697 r. o szansach wyborczych przyszłego króla polskiego Augusta II Wettyna przesądziło szczególnego rodzaju przekupstwo: uczta i pijatyka urządzone na polu elekcyjnym w noc z 26 na 27 czerwca 1697 r.
Power of a Mentor
Authors: Blancq Nathan-Jacques Le
Published: April 2023

In their first Student Column, Nathan-Jacques Le Blancq reflects on past experiences with mentors, and the pros and cons of varied or consistent mentorship.
Is A Single Particle Always Entangled?
Authors: Du Shengwang
Published: April 2023

We investigate the single-particle multi-mode "entanglement" and raise the questions: Is a single particle always entangled? Is entanglement a physical reality which is invariant under an arbitrary unitary transformation or choice of mode basis? We show that, if accepting the single-particle entanglement picture, a single particle can always be entangled by choosing a proper mode basis. This "mode entanglement", expressed as a superposition of single-particle mode basis, may have important applications in quantum information processing as it has some similar mathematical features as the multi-particle entanglement.
High prevalence of malaria in pregnancy among women attending antenatal care at a large referral hospital in northwestern Uganda: A cross-sectional study
Authors: Mangusho Caleb , Mwebesa Edson , Izudi Jonathan , Aleni Mary , Dricile Ratib , Ayiasi Richard M. , Legason Ismail D.
Published: April 2023

Background

Malaria in pregnancy contributes to substantial morbidity and mortality among women in Uganda. However, there is limited information on the prevalence and factors associated with malaria in pregnancy among women in Arua district, northwestern Uganda. We, therefore, assessed the prevalence and factors associated with malaria in pregnancy among women attending routine antenatal care (ANC) clinics at Arua regional referral hospital in north-western Uganda.

Methods

We conducted an analytic cross-sectional study between October and December 2021. We used a paper-based structured questionnaire to collect data on maternal socio-demographic and obstetric factors and malaria preventive measures. Malaria in pregnancy was defined as a positive rapid malarial antigen test during ANC visits. We performed a modified Poisson regression analysis with robust standard errors to determine factors independently associated with malaria in pregnancy, reported as adjusted prevalence ratios (aPR) and 95% confidence intervals (CI).

Results

We studied 238 pregnant women with a mean age of 25.32±5.79 years that attended the ANC clinic, all without symptomatic malaria. Of the participants, 173 (72.7%) were in their second or third trimester, 117 (49.2%) were first or second-time pregnant women, and 212 (89.1%) reported sleeping under insecticide-treated bednets (ITNs) every day. The prevalence of malaria in pregnancy was 26.1% (62/238) by rapid diagnostic testing (RDT), with the independently associated factors being daily use of insecticide-treated bednets (aPR 0.41, 95% CI 0.28, 0.62), first ANC visit after 12 weeks of gestation (aPR1.78, 95% CI 1.05, 3.03), and being in the second or third trimester (aPR 0.45, 95% CI 0.26, 0.76).

Conclusion

The prevalence of malaria in pregnancy among women attending ANC in this setting is high. We recommend the provision of insecticide-treated bednets to all pregnant women and early ANC attendance to enable access to malaria preventive therapy and related interventions.
Study of Learning Activities in Astronomy and Space of Primary School by Using Collaborative Learning
Authors:   Electrical Technology Department, Nakhon Si Thammaraaj Technical College,  Institute of Vocational Education Southern Region1, Pongkittikhun Pattara
Published: April 2023

The purposes of this research were to 1) develop the lesson plan, 2) compare the learning achievement of the teach model in Subject Pneumatics and Hydraulics by using Research-Based Learning , and 3) evaluate the students’ satisfaction on teaching model in Subject Pneumatics and Hydraulics by using Research-Based Learning. Experimental Research One Group Pretest – Posttest Design. Cluster Random Sampling as 20 higher vocational certificate students Nakhon Si Thammarat Technical College. These students were enrolled in the 30100-0104 “Pneumatics and Hydraulics” Course. The research instruments consisted of: 1 ) lesson plan, 2) questionnaire to get theopinions of specialists and teachers on the quality of the teaching model by using Research-Based Learning, 3 ) achievement test, and4 ) student opinion questionnaires. The research statistics included descriptive statistics and t-test dependence. The developed instruction set was validated for the quality by the specialist’s befor eimplementing with the sampling groups. The students did the pretest, completed the exercise, did the quizzes, and completed the worksheet of every unit. After that, the students did the achievement test, worksheet, and joined the practice test. All the scores including ethic scores were analyzed to find the effectiveness of the teaching model by using Research-Based Learning. Finally, the students were asked to report their opinion on this teaching model by using Research-Based Learning. The results can be concluded as follows. The specialists reported the quality of the lesson plan at highest level and high level. The efficiency of the teaching model in Subject Pneumatics and Hydraulics by using Research-Based Learning is 82.63/80.29 higher than the set criteria at 80/80. The learning achievement of the students through the teaching model in Subject Pneumatics and Hydraulics by using Research-Based Learning set was 0.5576 or 55.76%. The results of the difference between the pretest and the posttest scores of the students analyzed by the t-test revealed that the students achieved higher scores at the significant level of 0.05. The students reported high opinion on the teaching model in Pneumatics and Hydraulics Course by Research-Based Learning at high level.
John J. Simon: Socialist Editor, Writer, and Broadcaster
Authors: Foster John Bellamy , Mage John
Published: April 2023

Monthly Review editors remember the life of MR editorial board member John J. Simon (1934–2022), a dedicated socialist, towering figure in radical publishing and broadcasting.
Transfer of Paraguayan Eupatorium amambayense to Chromolaena (Asteraceae, Eupatorieae) with taxonomical notes
Authors: Salgado Vanina G. , Grossi Mariana A. , Gutiérrez Diego G.
Published: April 2023

Eupatorium amambayense, an endemism of Paraguay, was originally described within Eupatorium sect. Cylindrocephalum. Nowadays, genus Eupatorium is restricted to species from North America and Eurasia, and section Cylindrocephalum is a synonym of Chromolaena (Praxelinae). The objective of the work is to determine the current taxonomic identity of E. amambayense. Detailed comparative analyses of morphological traits, the protologue and type materials have revealed that the species belongs to Chromolaena and can be differentiated from the other genera of Praxelinae, especially Praxelis. As result the transfer of Eupatorium amambayense as Chromolaena amambayensis is proposed.
Population Analysis of Bali Sardinella (Sardinella lemuru, Bleeker 1853) Landed in PPI Kedonganan using Length-Weight Data and Digital Analysis (ImageJ)
Authors: Pertiwi Ni Putu Dian , Bestari Ida Ayu Purnama , Al Malik M. Danie , Phuong Mark Anthony
Published: April 2023

Sardinella lemuru, one of the important pelagic fish in Bali Strait waters, has been reported to be in the overfishing condition. Various studies have been conducted to understand its population condition. Length-weight data has been also widely used to understand the population dynamic of S. lemuru, although data collection generally using manual direct measurement methods, which has the disadvantages if used on the enormous number of samples. Therefore, this research aims to understand the significance of S. lemuru length measurement using digital image analysis (ImageJ) compared with the manual measurement. Moreover, this research also aims to understand the population condition of S. lemuru landed in PPI Kedonganan analyzed using its length-weight data. The result indicated no significance difference between length measurement using manual methods and digital image methods, thus conclude that digital image data can be used to measure the fish length and represent the accurate measurement. Population condition analysis showed that S. lemuru population is in isometric condition (b=3); with indication of declining in the length growth pattern compared with previous research (L∞= 20.75 cm with K= 1.1); the mortality estimation showed that fishing mortality (F=1.27) was lower than natural mortality (M=2.22), with the survival rate higher on smaller size fish. This research result can be used as an addition to the S. lemuru fisheries data and can also be used as reference methods to help conduct sampling and data collection more efficiently.
DNA Barcoding and Morphological Characters of Two Trevally Fish species (Caranx Spp.) Collected from Youtefa Bay, Papua, Indonesia
Authors: Kainama Tamara Louraine Jeanette , Wijayanti Diah Permata , Sabdono Agus , Dirgantara Dio
Published: April 2023

Trevally fish (Caranx spp,) or Kuwe fish (local name) are small pelagic fish that are mostly caught in the waters of Youtefa Bay. There are two types of Kuwe fish that are difficult to distinguish due to morphological similarities. These Kuwe fish have no scientific species identification so they have several different local names. Accordingly, it is necessary to identify and find out the proper naming of the two Kuwe fish. DNA barcoding is a technique used to speed up and simplify the process of identifying organisms. Hence, the purpose of this research was to identify the proper scientific name of the two Kuwe species in Youtefa Bay waters, as well as the kinship between these two types by applying a DNA barcoding technique. Nineteen Kuwe fish were sampled at Youtefa Bay, Jayapura, Papua in July 2022. Samples were studied morphologically, then carried directly to the Integrated Laboratory of Diponegoro University for molecular studies. DNA extraction, amplification, and DNA sequencing were carried out to further validate the species’ identification. The results showed that in the initial assessment of the specimens using taxonomic keys, 10 specimens were identified as Caranx sexfasciatus and 9 specimens were identified as Caranx tille. The relationship between length and weight of C. sexfasciatus and C. tille have resulted in b = 2.5754 with R2 = 0.8564 and   = 1.7119 with R2 = 0.6705, respectively. All identifications were confirmed as correct based on BLASTn results. The BLAST analysis demonstrated that 10 samples were closely related to C. sexfasciatus  (99%-100% in similarity) and 9 samples were similar to C. tille (97%- 99%). The genetic distance between individuals in C. sexfasciatus and C. tille has a value ranging from 0% - 0.2%, and the phylogenetic tree exposed that the two species are included in different clades. This study revealed that there are two species of Kuwe fish (C. sexfasciatus and C. tille) in Youtefa Bay, Papua, Indonesia.
Reviewing the impacts of international interventions on woodfuel governance in Cameroon
Authors: Kim D. , Ingram V.
Published: April 2023

Although international actors have intervened to improve the management of the Cameroonian woodfuel sector, the impacts of these interventions have been little explored. This study investigated the influence of international interventions on policy processes and their impacts on the
woodfuel actors and resources in Cameroon. Based on a systematically conducted review of English literature and five interviews, and using the international influence pathway framework as a conceptual lens, international norms and discourses, rules, and direct access were found to have influenced
woodfuel governance in Cameroon, while direct access to formal laws and policies and by programmes on the ground had more positive but also negative impacts. Due to the nature of the laws and policies which were influenced, the complex national woodfuel context, and the short-term and small-scale
characteristics of programmes, positive impacts on actors and resources created by international interventions were limited. These findings lead to recommendations to increase the scale and continuity of the programmes by ensuring more synergies with informal, local and international market-based
'rules', such as REDD+ and forest certification; to focus on increasing woodfuel supply and decreasing demand; and to focus more attention on involving and empowering local people in these policy processes.
An analysis of the institutional framework for REDD+ implementation in Cameroon
Authors: Alemagi D. , Nukpezah D. , Duguma L. , Fobissie K.
Published: April 2023

REDD+ is a mechanism that is used to advance the efforts of developing countries that are endowed with forests to mitigate climate change by decreasing emissions from deforestation and forest degradation, encouraging conservation and the sustainable management of forests, as well as
forest carbon enhancement. In this paper, using a qualitative approach, an analysis was conducted of the institutional framework that governs REDD+ implementation in Cameroon. The roles of the various institutions that play a role in advancing REDD+ implementation in Cameroon were profiled
followed by a literature review and, after interviews with REDD+ actors in Cameroon, the results of a SWOT analysis of the institutional framework for REDD+ implementation in Cameroon are presented. It is hoped that the findings of this study will be used by policy makers who are driving the
REDD+ process in Cameroon to craft and implement initiatives directed at promoting REDD+ implementation in the country.
PRODUKSI DAN UJI PERFORMANSI MESIN PEMBUAT BUBUR KERTAS KAPASITAS 960 LITER/JAM
Authors: Supraptono Supraptono , Kriswanto Kriswanto , Rozikin Ahmad , Fatoni Muhamad Hasan , Hasyim Fuad , Wijayanto Bagus
Published: April 2023

Tujuan penelitian ini adalah memproduksi mesin pembubur kertas dan menganalisis hasil pengujian performansi mesin bubur kertas dengan variasi jenis kertas dan lama waktu produksi. Penelitian ini merupakan penelitian terapan dimana pembuatan mesin menggunakan proses manufaktur sedangkan pengujian performansi mesin menggunakan metode eksperimen. Metode ekperimen dalam penelitian ini dengan melakukan uji coba performansi mesin bubur kertas dimana variabel bebas adalah jenis bahan kertas, dan waktu produksi, sedangkan variabel terikatnya adalah ukuran partikel, dan kapasitas produksi. Hasil uji performansi selanjutnya diamati menggunakan pemeriksaanmakroscopik menggunakan aplikasi infinity analyz. Hasil penelitian ini mendapatkan prototype mesin pembuat bubur kertas kapasitas 6 liter/jam dengan spesifikasi: panjang 1,29 m; lebar 0.646 m; tinggi 1,119 m; daya 1,5 HP. pengujian kapasitas produksi bubur kertas pada variasi waktu 3 menit yaitu sebesar 60 kg/jam, sedangkan hasil pemeriksaan partikel makrodidapatkan ukuran partikel besar lebih dari 1 mm hanya terdapat pada beberapa titik (minor) yang mungkin disebabkan dari bubur kertas yang terlempar ke dinding atas tabung  sehinggatidak terproses.
PENGARUH UKURAN PARTIKEL DAN TEKANAN KOMPAKSI TERHADAP KARAKTERISTIK BRIKET KAYU JATI
Authors: Briyartendra Endra Inggita , Widayat Widi
Published: April 2023

Tujuan dari penelitian ini untuk mengetahui pengaruh ukuran partikel dan tekanan kompaksi terhadap karakteristik fisik, mekanik dan thermal briket serbuk kayu jatitanpa perekat dan dengan perekat tepung kanji. Pada peneitian ini menggunakan spesimen sebanyak 90 spesimen dengan rincian, 40 spesimen pada proksimat, 12 spesimen pada ujidensitas, 12 spesimen pada drop test, 8 spesimen pada uji stability, 12 spesimen pada uji laju pembakaran. Jenis pemanfaatan limbah-limbah tersebut adalah dengan mengubahnya menjadi energi alternatif berupa briket. Pembriketan adalah pembentukan biomassa menjadi briket dengan cara dikompaksi. Penelitian ini menggunakan variasi tekanan 25 kg/cm2 dan 50 kg/cm2 serta variasi mesh 30, 40, dan 60. Karakterisasi yang dilakukan densitas, drop test, stability, proximate test, dan laju pembakaran. Hasil penelitian menunjukan kadar airpada briket setelah diberikan penambahan perekat kanji naik hingga 82,75%, kadar abu dan kadar zat terbang tetapi tidak terlalu signifkan hanya 7,13% dan 2,58%. Nilai kalor dankadar carbon mengalami penurunan yang sangat signifikan dengan adanya penambahan briket yang mencapai hingga 54,07% dan 38,51%. Nilai densitas mencapai 0,43 gr/cm3 dandensitas terendah didapat dengan tekanan 25 kg/cm2 pada mesh 30 yang hanya menghasilkan nilai densitas 0,33 gr/cm3. Droptest tidak berpengaruh terlalu signifikan hanya berkisar0,94% - 2,39% partikel yang hilang. Uji stabilitas menunjukan perubahan yang sangat signifikan terjadi hanya pada hari pertama dan kedua. Laju pembakaran pada tekanan 25 kg/cm2menunjukkan suhu maksimum yang dapat dicapai secara berurutan sebesar 584,18Â°C, 619,68Â°C, 644,18Â°C, 636,23Â°C. Sedangkan hasil pengujian laju pembakaran pada tekanan 50kg/cm2 menunjukkan suhu maksimum yang dapat dicapai secara berurutan sebesar 629,2Â°C, 645Â°C, 670,6Â°C, 598,53Â°C.
PENGARUH VARIASI ANYAMAN MATERIAL KOMPOSIT EPOXY BERPENGUAT BILAHAN BAMBU TERHADAP KEKUATAN BENDING
Authors: Utomo Fepbri Dwi , Widodo Rahmat Doni , Yudiono Heri
Published: April 2023

Penelitian ini dikaji karakteristik mekanik material komposit dari beberapa bahan organik yang mempunyai sifat ramah lingkungan dan banyak tersedia di wilayah Indonesia.Penelitian ini bertujuan untuk mengetahui pengaruh variasi anyaman terhadap sifat bending komposit anyam dengan variasi epoxy 75% dan anyaman bambu yang sebesar 25%. spesimen uji bending sesuai standar ASTM D790. Metode penelitian merupakan cara penelitian untuk memperoleh data yang diinginkan, sehingga pelaksanaan dan hasilnya dapat dipertanggung jawabkan secara kajian ilmiah. Pada pelaksanaan penelitian ini menggunakan metode eksperimen yakni mencari hubungan sebab akibat antara faktor-faktor lain yangsengaja ditimbulkan oleh penelitian. sehingga penelitian akan lebih terarah dalam proses pelaksanaannya dan hasilnya dapat dipertanggung jawabkan secara kajian ilmiah. Penelitianyang dilaksanakan ini menggunakan metode eksperimen. Hasil uji bending pun menunjukkan bahwa spesimen anyaman matrik resin epoxy dengan variasi anyaman plain, twin, dancampuran sebesar 86,7 N/mm2 ; 97,38 N/mm2 ; 86,08 N/mm2. dengan nilai modulus elastisitas bending sebesar 3,294 MPa; 1,049 MPa dan 1,282 MPa serta memiliki nilai momen bending sebesar 57,8 MPa; 64,925 MPa dan 57,387 MPa secara berturut-turut. Variasi anyaman twin memiliki kekuatan bending dan momen bending tertinggi diantara bentuk anyaman yang lain sebesar 97,38 N/mm2 dan sebesar. 64,925 MPa. Sedangkan untuk anyaman plain memiliki modulus elastisitas tertinggi diantara bentuk anyaman yang lain yaitu sebesar 3,294 MPa.
Analisis Variasi Kecepatan Potong Dan Kedalaman Potong Terhadap Nilai Kekasaran Permukaan Dan Getaran Pada Pembubutan Silindris Material Baja ST 60
Authors: Rosandi Anwar , Sumbodo Wirawan , Yudiono Heri , Kriswanto Kriswanto
Published: April 2023

Mesin bubut konvensional masih sering dipakai, tetapi permasalahannya mesin bubut konvensional sulit mendapatkan kualitas produk yang benar-benar baik (dimensi geometri, kekasaran permukaan dan reflektif geometri yang sesuai) Disebabkan karena faktor dari manusia, parameter pemotongan yang digunakan dan faktor kondisi mesin itu sendiri. Tujuan dalam penelitian ini untuk mengetahui untuk mengetahui seberapa besar pengaruh kecepatan potong dan kedalaman potong terhadap getaran dan kekasaran permukaan pada proses pembubutan silindris. Penelitian ini termasuk jenis penelitian kuantitatif  menggunakan metode eksperimen. Untuk pengumpulan data menggunakan teknik metode observasi dan dokumentasi. Teknik analisis data menggunakan teknik analisis regresi.  Hasil penelitian yang telah didapatkan, diketahui nilai getaran mesin yang tertinggi adalah 5.4 m/s2 dan yang terendah adalah 1.8 m/s2. Nilai getaran rumah pahat yang paling tinggi adalah 5 m/s2 dan yang terendah adalah 1 m/s2. Dan untuk yang kekasaran permukaan yang paling tinggi adalah 5.0 Âµm dan yang terendah adalah 2.33 Âµm. Serta dapat disimpulkan bahwa semakin tinggi kecepatan potong dan kedalaman potong maka getaran mesin, getaran rumah pahat dan kekasaran akan semakin tinggi.
ПЕДАГОГІЧНИЙ ЕКСПЕРИМЕНТ З ПІДГОТОВКИ МАЙБУТНЬОГО ВЧИТЕЛЯ ДО ФОРМУВАННЯ ПІДПРИЄМЛИВОСТІ МОЛОДШИХ ШКОЛЯРІВ
Authors: МАКАРУК ОЛЬГА
Published: April 2023

У статті експериментально перевірено ефективність педагогічних умов підготовки майбутнього вчителя до формування підприємливості молодших школярів в освітньому процесі педагогічного коледжу: актуалізація позитивної мотивації та цілеспрямованості до формування підприємливості молодших школярів; інтенсифікація освітнього процесу підготовки майбутнього вчителя до формування підприємливості молодших школярів через інтеграцію змісту навчальних дисциплін; активізація набуття індивідуального досвіду рефлексії готовності майбутнього вчителя до формування підприємливості молодших школярів через запровадження інтерактивної взаємодії у форматі "викладач-студент-учень". Підготовлено й упроваджено в освітню практику закладів фахової передвищої освіти навчально-методичне забезпечення з підготовки майбутнього вчителя до формування підприємливості молодших школярів, що презентовано навчально-методичним посібником "Підготовка майбутнього вчителя до формування підприємливості молодших школярів"; навчально-методичними рекомендаціями для викладачі циплін професійної підготовки, контекстний зміст яких сприяє формуванню готовності майбутнього вчителя до формування підприємливості молодших школярів в освітньому процесі педагогічного коледжу; збагачено навчально-професійний ресурс підготовки майбутнього вчителя до формування підприємливості молодших школярів в освітньому процесі педагогічного коледжу через доповнення тем лекційних, практичних занять з курсу "Розвиток творчих здібностей молодших школярів" у площині дослідження ("Креативність і підприємливість - провідні особистісні якості", "Підприємливість як вияв творчих здібностей молодших школярів")
СУЧАСНІ ПРОБЛЕМИ РОЗВИТКУ КОМУНІКАТИВНОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ ФАХІВЦІВ З ПСИХОЛОГІЇ
Authors: ШКУРКО АНГЕЛІНА
Published: April 2023

У статті автором проаналізовано науково-педагогічну, методичну та спеціальну літературу, нормативноправові документи з метою виявлення сучасних проблем розвитку комунікативної компетентності майбутніх фахівців з психології, а саме: відсутність чітких визначень понять; недосконале методичне забезпечення розвитку комунікативної компетентності у вищій освіті; невідповідність затребуваності майбутніх фахівців з психології на сучасному ринку праці; цілеспрямований процес розвитку комунікативної компетентності майбутніх фахівців з психології у ЗВО.
Concepto de computabilidad en Alan Turing
Authors: Salinas Molina Miguel
Published: April 2023

Reflexionamos sobre el concepto de computabilidad, conceptos definidos en la década de los años 30 del siglo XX, basado en la conocida tesis de Church-Turing; que dice que una función matemática recursiva es equivalente a lo que ejecuta la máquina de Turing que contiene la idea de algoritmo, noción intuitiva de secuencia de instrucciones. Desde una perspectiva crítica (por lo tanto filosófica), consideramos que la tesis de Church-Turing no contiene plenamente la teoría de computabilidad que profesó Alan Turing, que las ideas de Turing tienen un sentido más amplio.
Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension: Clinical Outcomes
Authors: Lang Irene M
Published: April 2023

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare major vessel pulmonary vascular disease that is characterised by fibrotic obstructions deriving from an organised clot. Recent advances in treatments for CTEPH have significantly improved outcomes. Apart from classical surgical pulmonary endarterectomy, balloon pulmonary angioplasty (BPA) and vasodilator drugs that were tested in randomised controlled trials of non-operable patients are now available. In Europe, CTEPH affects males and females equally. In the first European CTEPH Registry, women with CTEPH underwent pulmonary endarterectomy less frequently than men, especially at low-volume centres. In Japan, CTEPH is more common in females and is predominantly treated by BPA. More data on gender-specific outcomes are expected from the results of the International BPA Registry (NCT03245268).
Take the plunge
Authors: Garcia Rosa Rodrigo
Published: April 2023

Phraseology has proven to be an important aspect of languages; as such, linguistic theories were forced to reshape their explanatory tools so as to incorporate this important aspect of language to their descriptive models. In light of this, analogous areas such as first and second language acquisition theories have all acknowledged the importance of speakers’ phraseological knowledge in real communication, both in L1 and L2 acquisition settings and in general language use. Nevertheless, despite being a relatively well-known phenomenon in theoretical studies, little has been said about the relationship between phraseology and syntax. More specifically, the idea of using phraseology as a starting point for the teaching of schematic grammatical structures seems to be a promising area of application and investigation. This paper aims to contribute to this area by presenting some ideas on how phraseology can be used as a springboard for the teaching of grammar.
Keap1/Nrf2-independent antioxidative activity of Phyllanthus amarus extract in zebrafish
Authors: Thanh Nguyen Vu , Nguyen Thi Tam Thanh , Phuong Phi Nguyen , Mai Que Duong Nguyen , Thu Hien Luu , Phuong Hanh Le Luu , Phuong Thao Ngo Huynh , Nguyen Xuan Tong , Thanh Luu Pham , Thuy Vy Nguyen Hoang , Thi Thuy Dinh
Published: April 2023

The Keap1 protein (Kelch-like ECH-related protein 1) and the Nrf2 transcription factor (NF-E2-related factor 2) are important systems for maintaining homeostasis, redox, and metabolism. Based on the Keap1/Nrf2 pathway, the antioxidative mechanism of P. amarus extract (PAE) was predicted. In this paper, we evaluated the protective effects of PAE on the oxidative toxicity induced by sodium arsenite (NaAsO2) and hydrogen peroxide (H2O2) in zebrafish larvae. We first determined that the LC50 values for NaAsO2, H2O2, and PAE at 3.5 days postfertilization (dpf) were 1 mM, 3 mM, and 200 μg/mL, respectively. Then, to assess the antioxidant effects of P. amarus, 3.5 dpf zebrafish larvae were pretreated with PAE at concentrations of 0, 50, 75, and 100 μg/ml for 12 h, and then the PAE solution was replaced with 1 mM NaAsO2 or 3 mM H2O2 to assess challenge survival within 48 h. Interestingly, all three concentrations, 50, 75, and 100 μg/mL PAE, increased the survival rate of zebrafish larvae compared to those larvae exposed to only 1 mM NaAsO2. Similarly, PAE at concentrations of 75 and 100 μg/mL protected zebrafish larvae after exposure to 3 mM H2O2. Real-time qPCR analysis was performed after 3.5 dpf zebrafish larvae were exposed to 100 μg/mL PAE for 12 h to verify whether the increasing antioxidative activity is depended on the Nrf2 pathway. The expression of the Nrf2 target genes glutathione-S-transferase Pi 1 (gstp1) and peroxidase 1 (prdx1) was assessed using real-time qPCR. However, the expression of this gene was not significantly different between control larvae and PAE-treated larvae. Thus, PAE induces antioxidant activity in zebrafish in a Keap1/Nrf2-independent manner.
CURRÍCULO E EDUCAÇÃO INFANTIL
Authors: Lopes Denise Maria de Carvalho , Leal Fernanda de Lourdes Almeida , Amorim Ana Luisa Nogueira de
Published: April 2023

O artigo problematiza o currículo na Educação Infantil à luz do debate sobre concepções, legislações e (in) visibilidades. A discussão acerca de questões curriculares nesta etapa da Educação Básica tem ganhado espaço no movimento histórico da própria constituição da educação institucionalizada de crianças de zero a cinco anos, envolvendo sua função, finalidade, objetivos e organização, ou seja, sua identidade. Apesar desse espaço, não se trata de tema objeto de consenso entre intelectuais, docentes e pesquisadores da área. E isso se dá desde a própria concepção de currículo à sua relação com a Educação Infantil. Também, no âmbito das problematizações, ressaltam-se contextos e sujeitos ainda ausentes desse debate, o que também aponta para a garantia de direitos: as crianças de zero a cinco anos residentes em áreas rurais do país. Em meio às múltiplas teorizações que definem a(s) criança(s), a(s) infância(s) e sua educação, bem como seus desdobramentos em legislações, políticas e orientações para as práticas pedagógicas – que, por sua vez, impulsionam novas teorizações – emergem lacunas, desconhecimentos, invisibilidades – de processos, de contextos, de sujeitos, de práticas.
ENHANCING THE CRYOGENIC IMPACT TOUGHNESS OF FERRITIC STEEL BY MULTI-TYPE AND FINE-MICROSTRUCTURE DESIGN
Authors: Liu Zi-cheng , Gao Peng , Ren Jia-kuan , Li Cheng-gang , Zhong Wu-bo , Hu Zhan , Liu Zhen-yu
Published: April 2023

Based on pure melting, multi-type and fine-microstructure design, a ferritic steel with an outstanding combination of cryogenic impact toughness and strength was fabricated. The microstructure was characterized by means of optical microscopy, electron back-scattered diffraction and transmission electron microscopy. The steels with different final cooling temperatures of 663 °C and 560 °C show ferrite and perlite microstructure, and ferrite grain size can be refined from 3.15 µm to 2.67 µm by lowering the final cooling temperature from 663 °C to 560 °C. Moreover, a higher volume fraction of acicular ferrite and polygonal ferrite can be obtained for a lower final cooling temperature of 560 °C. Hence, the cryogenic impact toughness can be enhanced, and the brittle failure can be suppressed, even at –110 °C, showing a higher impact toughness compared with other ferritic steels.
ROLE OF OLIVINE AGGREGATE IN LIME AND CEMENT MORTARS FOR THE SEQUESTRATION OF ATMOSPHERIC CO2
Authors: Saridhe Sriram Pradeep , M. Hareesh  , Shanmuga Priya T  , Selvaraj Thirumalini
Published: April 2023

Construction industry is majorly criticised due to a great liberation of carbon dioxide (CO2) into the atmosphere. Researchers have identified various techniques to capture the atmospheric CO2. Nevertheless, the recognised methods have both merits as well as demerits. Thus, scientific communities are working on simple and easily exhibited ways of capturing atmospheric CO2. One such technique is the conversion of gaseous CO2 into stable calcium/magnesium carbonates. The present study was conducted to identify the carbon-capturing efficiency of olivine aggregate in cement and lime mortars. Olivine aggregate has a tendency to change its mineral structure under alkaline environment and it is able to interact with atmospheric CO2 to form a stable carbonate. Analytical techniques (XRD, TGA) were conducted to elucidate the formation of hydrated phases formed in both lime and cement mortars. The study concluded that the addition of olivine sequestered atmospheric CO2 and converted it into magnesium carbonate. Out of the lime and cement mortar, lime mortar captured a greater amount of CO2 and produced stable compounds.
EFFECT OF A SCANDIUM ADDITION ON ANODIZING AlMg ALLOYS
Authors: Karpe Blaž , Kern Katarina , Kovač Janez , Klanjšek Gunde Marta , Nagode Aleš , Bizjak Milan , Zorc Matija
Published: April 2023

Scandium (Sc) is known to be one of the most effective alloying elements of aluminum alloys. The only drawback is its high price, but that could change quickly due to the promising results of recent research on its extraction. However, the data on how it affects anodic oxidation are very scarce. In this research, we analyzed how a micro-addition of Sc to the AlMg alloy affects the growth mechanism and properties of the protective aluminium oxide layer depending on the anodization parameters. For comparison, alloy AA5083 with a similar magnesium content was also anodized with the same anodizing parameters. In all experiments, sulfuric acid (VI) with concentrations of 1.72 M or 2.2 M at temperatures of 21 °C or 35 °C was used as the electrolyte. Potentiostatic (18 V) and galvanostatic (20 mA/cm2) anodizing methods were applied. The results (SED-EDS) show that scandium is uniformly intercalated in the matrix of the oxide layer and decreases its resistivity, which increases the oxide growth rate during potentiostatic anodizing and decreases the pore density and pore diameters during galvanostatic anodizing. Moreover, it increases the mobility of cations through the oxide layer, thus accelerating the oxidation reaction in concentrated sulfuric acid electrolytes. On the other hand, the increased cation mobility considerably increases the sensitivity to the temperature of the electrolyte, which can change the growth mechanism of the oxide layer and thus its morphology.
MULTI-ELECTRODE TRANSCUTANEOUS ELECTRICAL STIMULATION OF THE HUMAN EXTERNAL EAR
Authors: Pečlin Polona , Rozman Janez , Janež Renata , Emri Anja , Ribarič Samo , Mirković Tomislav
Published: April 2023

This article reviews the development of a new concept for crafting and testing a multi-electrode set-up for selective transcutaneous auricular nerve stimulation (tANS) using particular superficial regions of the external ear (EE). The purpose of the work is to assess the mechanical properties of the set-up to ensure the optimum conditions for the users, and to test the ability to affect vital physiological functions. The set-up consisted of eight cap-like platinum simulating cathodes (S = 14.58 mm2) that were embedded in the left and right silicone ear plugs. The plugs were mounted onto the frame of dummy headphones and inserted into the EE, while a common anode (anode) (S = 4500 mm2) was placed at the nape of the neck. The mechanical performance was assessed by measuring the axial force Fx acting on each cathode against the bending of the dummy headphone frame while simulating the conditions of the set-up being mounted onto the head. The functionality was tested by applying stimuli onto four predefined sites at the EE to modify particular vital physiological functions of female volunteers. The preliminary results show that during the tANS, the bi-nasal respiration became shorter but more frequent with steeper inspiration and a lower airflow. The results also show that during the tANS, the heart rate was slightly diminished along with the respiratory sinus arrhythmia. Finally, a dicrotic notch within the toe photoplethysmogram was masked by the waves with a frequency of approximately 300 min–1. The presented work has implications for the multi-electrode set-up design and the prediction of efficient tANS used to modify physiological functions.
Programa de exercícios físicos por telerreabilitação em idosos com doença de Parkinson: um estudo experimental
Authors: Moraes Janine Brasil de Araújo , Ribeiro Breno Caldas , Nunes Letícia de Cássia Tavares , Costa Brunna Gabrielli Freitas da , Silva Caio Geovanni Reis , Costa Carina Alves , Teixeira Renato da Costa , Carneiro Saul Rassy , Jacob Mellina Monteiro
Published: April 2023

INTRODUÇÃO: As restrições durante a pandemia do COVID-19 limitaram o acesso a centros de reabilitação especializados para tratamento fisioterapêutico de pessoas com Doença de Parkinson (DP). Sabe-se que a falta de exercícios físicos pode agravar as condições de saúde, levar à piora dos sinais típicos da doença e promover o declínio funcional. A telerreabilitação é uma estratégia que pode restaurar o acesso e facilitar a continuidade de assistência fisioterapêutica. OBJETIVOS: Avaliar os efeitos de um programa de exercícios físicos por telerreabilitação no nível de atividade física, no desempenho funcional de Membros Inferiores (MMII), no desempenho nas atividades de vida diária (AVD’s) e na qualidade de vida (QV) em idosos com DP. MATERIAIS E MÉTODOS: Trata-se de um estudo experimental, descritivo, longitudinal, em que foram avaliados os efeitos da intervenção por telerreabilitação composta por 12 sessões de 1 hora, feitas 3 vezes/semana, realizada estatística analítica para fins comparativos pelo Teste t de Student. RESULTADOS: 22 participantes concluíram o estudo. Foi observada mudança significativa no nível de atividade física (IPAQ inicial de 0,18 ±0,39 e final de 1,0 ± 0, p = 0,0001), no desempenho funcional dos MMII (teste de sentar e levantar cinco vezes (TSLCV) tempo médio pré 16,22 ± 7.41, e após 12.26 ± 2.83, p= 0,0197), no desempenho nas atividades de vida diária (Brazilian OARS Multidimensional Functional Assessment Questionnaire (BOMFAQ) de 26,13 ± 6,31 e após de 35,45 ± 5,16, p = 0,0001) e na QV dos idosos com DP (PDQ-39 inicial de 45,92 ±15,36 e final de 23,63 ± 10,19, p = 0,0001). CONCLUSÃO: Conclui-se que houve mudança no nível de atividade física, no desempenho funcional de MMII, no desempenho nas AVD’s e na QV.
Autofluorescence Microscopy Data Acquisition v1
Authors: Kruse Angela
Published: April 2023

Scope: Obtain autofluorescence microscopy images of tissues. Expected Outcome: An RGB autofluorescence microscopy image of the tissue section that enables visualization of tissue morphology as well as registration and correlation of different imaging modalities on a pixel by pixel basis.
5. Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms v1
Authors: Payami Haydeh
Published: April 2023

The protocol details the final product , the published manuscript with step-by-step methods. It describes the whole process from start to end using the article "Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms".
[Modified] Lake ABPS Protocol - University of Maine v1
Authors: Huston Grayson
Published: April 2023

A modified version of the Lake ABPS protocol as described in Thomson-Laing et al. 2022 Protocol successful at detecting fish sedDNA collected from lake surface sediments, as well as river sediments during an anadromous fish sea-run migration
[Modified] DNeasy PowerSoil Pro Kit_Increased Sediment Volume & Inhibitor Removal Pre-Extraction v1
Authors: Huston Grayson
Published: April 2023

Protocol (wash buffer plus modified extraction) unsuccessful at detecting fish sedDNA from lakes in Maine, USA Protocol successful at detecting fish sedDNA collected from streams during an anadromous fish sea-run migration