bluuebunny/crossref_metadata_2025 huggingface dataset:
Elastomeric silicone foam - an antibacterial environment or a new habitat for bacteria?
Authors: Rebane Ingrid , Priks Hans , Levin Karl-Jakob , Sarigül İsmail , Mäeorg Uno , Johanson Urmas , Piirimägi Peeter , Tenson Tanel , Tamm Tarmo
Published: February 2023

Silicone is often used in environments where water repellency is an advantage. Contact with water promotes the adhesion of microorganisms and biofilm formation. Depending on the application, this may increase the possibility of food poisoning and infections, the material's degrading appearance, and the likelihood of manufacturing defects. The prevention of microbial adhesion and biofilm formation is also essential for silicone-based elastomeric foams, which are used in direct contact with human bodies but are often difficult to clean. In this study, the microbial attachment in and the retention from the pores of silicone foams of different compositions is described and compared to those of commonly used polyurethane foams. The growth of the gram-negative Escherichia coli in the pores and their leaching during wash cycles is characterised by bacterial growth/inhibition, adhesion assay, and SEM imaging. The structural and surface properties of the materials are compared. Despite using common antibacterial additives, we have found that non-soluble particles stay isolated in the silicone elastomer layer and, therefore, do not possess antibacterial activity. Water-soluble tannic acid dissolves into the medium and seems to aid in inhibiting planktonic bacterial growth, indicating that tannic acid is available on the surface of the SIFs to some extent.
Mathematical Modelling of Radicalization And Terrorism Dynamics in the Central Sahel
Authors: ZOROM Malicki , LEYE Babacar , COLY Serigne M'backé , DIOP Mamadou , GANA Abdou LAWANE , BOLOGO/TRAORE Maïmouna , NIANG Dial
Published: February 2023

The increase in violence has created an unprecedented crisis in the Sahel, particularly the Central Sahel, with massive displacement of populations already vulnerable to climatic hazards. This paper aims to propose a mathematical model of the ordinary differential equation system that will reflect the dynamics of terrorism and internal displacement. Sobol's sensitivity analysis of the model's parameters will allow us to make proposals for reducing terrorism. Military actions alone do not contribute effectively for fight against terrorism because they only contribute less than 20\%. Radicalization prevention and de-radicalization strategies must be adopted jointly to effectively reduce the spread of terrorism because they contribute more than 80\% on the fight against terrorism.
Granular Foveolae in the Groove of the Sigmoid Sinus: Anatomical Study
Authors: Guduri Pavan , Ekanem Uduak-Obong I. , Olewnik Łukasz , Cardona Juan J. , Iwanaga Joe , Dumont Aaron S. , Tubbs R. Shane
Published: February 2023

Granular foveolae in the groove of the sigmoid sinus have rarely been reported in the literature compared to numerous published reports on the granular foveolae near the superior sagittal sinus and its sulcus on the internal aspect of the calvaria. The present study was performed to better elucidate their prevalence and locations. One hundred and ten adult dry skulls (220 sides) were analyzed for the presence of granular foveolae within the groove of the sigmoid sinus. The exact position of the foveolae was documented and the diameter of the granular foveola were measured. Granular foveolae were found in the groove of the sigmoid sinus on 3.6% of sides. These were at or within a mean of 1.3 cm inferior to the transverse-sigmoid junction. When a mastoid foramen was noted in the groove, it was always located more inferior to the granular foveolae when present. The mean diameters of the granular foveolae of the left groove of the sigmoid sinus was 2.8 mm and 4 mm for right grooves. The mean depth of the granular foveolae of the left groove of the sigmoid sinus was 2.7 mm and 3.5 mm for right grooves. Granular foveolae were statistically larger and deeper on right versus left sides (p < 0.05). Granular foveolae of the groove of the sigmoid sinus were identified most commonly on right sides and on 3.6% of all sides. If identified on medical imaging, these uncommon structures at the skull base should be considered normal anatomical variations.
Considerations on the ecology of Rubiaceae in Martinique (Lesser Antilles)
Authors: CLAUDE Jean-Philippe , JOSEPH Philippe , ABATI Yelji , MAJOR Péguy , JEAN-FRANCOIS Yanis , ELY-MARIUS Séverine , SOPHIE Stéphane
Published: February 2023

The Rubiaceae family is an essential component of the flora of the Lesser Antilles archipelago located in the Caribbean. There are 129 species of Rubiaceae divided into 54 genera, including 20 endemic species. Martinique, a mountainous island occupying a central position in the archipelago, is home to 89 species of the family divided into 41 genera, including 2 endemic species. More than twenty species are grown or used as decorations, but the diversity of Rubiaceae found naturally in natural vegetation is significant, in terms of the number of species, genera or physiognomic types. As part of a doctoral thesis carried out in Martinique between 2015 and 2020, our knowledge about the ecology of this family has been enriched. In total, 120 floristic inventories were carried out in various natural plant formations. These data have undergone multivariate statistical processing, in particular using EXCEL and XLSTAT software. In total, 27 Rubiaceae species divided into 18 genera were observed (trees, shrubs, herbs, vines and epiphytes). Although the diversity and abundance of Rubiaceae vary according to the bioclimatic and therefore altitudinal gradient of the island, they are nevertheless rarely part of the dominant species assemblages. Due to the new climatic constraints of the 21st century, the current chorology of these species will evolve.
Mathematical analysis of fractional order Tumor-Immune Response Model via an efficient computational technique
Authors: Gill Vinod , Samuel Shikaa , Rana Seetu , Singh Yudhveer
Published: February 2023

A mathematical description of the tumor-immune response model using the Caputo fractional order derivative operator (CFD) is described in this research paper. Four distinct cell populations—tumor cells (TCs), effector cells (ECs), helper tumour cells (HTCs), and regulatory T cells (Tregs)—make up the suggested model. The collection of fractional ordinary differential equations simulates the interaction between various cell populations. The authors obtained the series solutions for the corresponding cell populations of the considered model via Sumudu Transform Homotopy Perturbation Method (STHPM). By providing various ICs and numerical values for the associated model’s parameter, numerical simulations and graphical analysis are also performed.
Improving Thoracic Surgery Ward Round Quality and Enhancing Patient Safety in a referral centre
Authors: Pons Aina , Alshammari Abdullah , Kaniu Daniel , Asonitis Athanasios , Bashir Ryan , Boyle Mark , Alvarez-Gallesio Jose , Proli Chiara , Chavan Hema , Begum Sofina , Jordan Simon , Buderi Silviu
Published: February 2023

Introduction
Ward rounds are complex clinical processesthat provide an opportunity for daily review and management of thoracic surgery inpatients (1). The aim of this study was to evaluate the thoracic surgical ward round documentation against the guidelines and recommendations and facilitate a pathway template to improve this process and enhance patient care.
Materials and Methods
Data for this audit was collected retrospectively and prospectively. Data was collected during three auditing periods and managed on Microsoft Excel. Descriptive statistics were used for its analysis. Chi-square and Fisher’s Exact tests were used to test for difference in reporting rates.
Results and Discussion
Initially, a total of 199 ward round notes were reviewed. Imaging results (19%) and discharge planning (23%) were not reported. eCARE (electronic Clinical Assessment for Round Evaluation) was developed to ensure that all aspects of patient evaluation recommended by the guidelines were included. Reporting rates significantly improved after such changes. We analysed the effect of the new ward round note on discharge planning (23.3 vs 41%, p<0.001), complication rates (32.6 vs 21.9%, p=0.03), post-surgical length of stay (LOS) (7.0 vs 5.0, p<0.001).
Conclusion
Over a year, we audited the compliance of the Thoracic Surgery Department against national standards for ward round documentation. Several important items were not regularly reported. Using closed-ended questions improved reporting rates, and patient safety was optimised. Further research should explore the impact of this new documentation method on patient care and postoperative outcomes in our Trust as well as other Cardiothoracic centers.
Comparison of Heart Disease Prediction Using different Machine Learning Algorithms
Authors: Dass Ashish Kumar
Published: February 2023

Heart disease is a dreadful threat to the human society that affects globally. Any heart condition and its background should be identified as early as possible to enhance the likelihood of survival. After risks are identified, it helps to anticipate sickness in patients which facilitates a more meaningful, effective, and commercial management of health resources. Low detection accuracy and rising processing complexity are issues with the current research approaches. To overcome such problems. This paper analyses detection and classification of heart disease using different machine learning algorithm. The cause of this work is to hit upon coronary heart illness at early level and keep away from results with the aid of using imposing machine learning algorithm like Naïve Bayes , Decision Tree, Random Forest ,K –Nearest-Neighbor ,Suppoort vector machine(SVM) and logistic regression. The results compared with Precision, Recall, F1 Score and Area Under Curve matrices to understand the efficiency of available algorithms.
Fifth fundamental force and unification of fundamental forces
Authors: Singh Raghvendra
Published: February 2023

There are four known fundamental forces of nature and there is a need to combine them into a unified theory. Progress has been made toward this goal but gravity remains an issue. However, the four forces are body forces that act on points. They together do not make the universe a closed system. Here, I identify a surface force, which acts outward normal to the surface of the universe. Further, using a water drop hanging in a vacuum as a model, I provide a formula to find the magnitude of this force. The fifth force is generated by surface tension, a property of dark energy. On the other hand, matter particles interact with each other through cohesive forces and with dark matter through adhesive forces. I give the functional forms of all cohesive and adhesive forces and present an equation that unifies all the forces of nature.
Interdire la mendicité sans violer les droits humains ?
Authors: Zimmermann Nesa , Da Rugna Antoine
Published: February 2023

Le 19 janvier 2021, la Cour européenne des droits de l'homme a rendu son arrêt très attendu dans l'affaire Lăcătuş c. Suisse au sujet de l'interdiction de la mendicité, qui est désormais définitif. Le canton de Genève y a répondu en modifiant sa disposition litigieuse sur la mendicité, ce qui a fait l'objet d'un arrêt de la Chambre constitutionnelle genevoise le 28 juillet 2022. Cet arrêt valide sous l'angle abstrait la nouvelle teneur de la loi genevoise qui interdit désormais la mendicité sur des critères géographiques et comportementaux. Le présent article examine de manière critique cette réponse, en revenant notamment sur la jurisprudence de la Cour EDH. Il apporte également des réflexions pour l'évolution future de la jurisprudence.

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Am 19. Januar 2021 fällte der Europäische Gerichtshof für Menschenrechte (EGMR) sein mit Spannung erwartetes Urteil im Fall Lăcătuş gegen die Schweiz zum Bettelverbot, das nun endgültig ist. Der Kanton Genf reagierte darauf, indem er seine strittige Bestimmung zur Bettelei änderte, die kurz darauf am 28. Juli 2022 Gegenstand eines Urteils der Genfer Verfassungskammer wurde. Ihr Urteil validiert unter abstrakten Gesichtspunkten den neuen Wortlaut des Genfer Gesetzes, das Betteln nun aufgrund von geografischen und verhaltensbezogenen Kriterien verbietet. Der vorliegende Artikel setzt sich kritisch mit diesem Entscheid auseinander und geht dabei insbesondere auf die Rechtsprechung des EGMR ein. Er liefert auch Überlegungen für die zukünftige Entwicklung der Rechtsprechung.
No Evidence Sowing Date Influences Optimum Plant Density of Sweet Corn Grown in the Midwestern United States
Authors: Williams Martin M. , Dhaliwal Daljeet S. , Hausman Nicholas E.
Published: February 2023

Sweet corn (Zea mays L.var. rugosa or saccharata) is sown across a wide range of dates to provide a steady supply of marketable ears for fresh market and processing. There is a perception in the sweet corn industry that plant density tolerance declines in late-season plantings in the midwestern United States; however, publicly available data to support this perception cannot be found. Using field experiments, the objectives of this research were to quantify the effect of the sowing date on growth responses to plant density and determine the extent to which the sowing date influences the optimum plant density and maximum yield/profit. There were few main effects or interactions of the sowing date on crop growth. More importantly, there was no effect of the sowing date on the economically optimum plant density or plant density that optimized yield. Although variations exist in sweet corn optimum plant densities in the midwestern United States, these variations are likely driven by several factors other than the sowing date that have not yet been fully characterized.
EXPLORING STUDENTS’ RESPONSES TO THE “MISSYOU” LYRIC GAME ON LEARNING LISTENING
Authors: Sari Hesty Puspita
Published: February 2023

The purpose of this study is to see how students react to using the "Missyou" Lyric Game in listening activity. This study uses a qualitative research design. The participants in this study were 20 students from SMPN 1 Srengat who were chosen at random. A questionnaire was used to gather information. The purpose of the questionnaire is to collect student responses and determine whether the "Missyou" Lyric Game model explores and develops students' listening ability as an alternative media for learning to listen. The results revealed that 81,65 percent of respondents agreed that song lyrics may enhance their listening skills.
EFL STUDENTS’ PERCEPTION ON TEACHERS’ ROLES IN ONLINE LEARNING ENVIRONMENT: A STUDY SURVEY
Authors: Adzikri Fhazil , Ardini Anandayu Suri
Published: February 2023

As a result of the COVID-19 epidemic, public schools have been obliged to switch from face-to-face instruction to online or distance learning only. Teachers may have a more challenging time dealing with the pandemic since they are used to working offline and now must do so online. This study aims to determine how EFL students perceive instructor responsibilities in an online learning environment, and the study's difficulty is how these students perceive teacher roles. The Scale of Teacher Role Inventory (STRI), a tool established by Huang, is utilized to gather data for this study. Student feedback on their work, emotional support, and classroom management were all useful in the results from the three sections. To complete this study question's data, English language education students from a Yogyakarta university were requested to answer 27 questions. Each portion of the questionnaire had varied findings, although the values were comparable. In the cognitive role component, students appreciated lecturers' comments or feedback on their work (M=4.58 SD=0.64), but practice question advice earned the lowest score (M=4.34 SD=0.73). In terms of emotion, the lecturer has offered good help, with the best score received when the lecturer encouraged students to explore their answers and results (M = 4.32, SD = 0.72) and the lowest score gained when the lecturer made learning stressful (M = 3.29, SD = 1.32). This component is the lowest, but the computation is reversed, showing that students are not under pressure from lecturers. Students believed the lecturer crafted a good semester-long course plan (M=4.52, SD=0.61). Students considered lecturers lacked control over learning rate hence this assessment utilized the lowest possible score (M = 4.15, SD = 0.85).
PROMPTING FACTORS CULTIVATING INDONESIAN EFL LEARNERS’ LEARNING AUTONOMY BEHAVIORS
Authors: Wijaya Kristian Florensio
Published: February 2023

Previous research results unearthed that highly-autonomous EFL learners are more inclined to possess a higher sense of ownership of their learning enterprises owing to the advanced level of learning management. This library study was a further attempt enacted by the researcher to profoundly investigate particular factors believed to cultivate Indonesian EFL learners’ learning autonomy behaviors. In light of this major research objectivity, 30 previous learning autonomy literature were selectively selected to shed clearer enlightenment for Indonesian EFL experts, practitioners, curriculum designers, and educators to start internalizing various meaningful learning activities consolidating learners’ autonomous learning behaviors. Generally speaking, the obtained research results unveiled that the constant nourishment of Indonesian EFL learners’ learning autonomy behaviors can be insured in case second language teachers are committed to promoting more facilitative and innovative learning enterprises in their daily routines. In conformance with these research results, it is of foremost importance for second language teachers to organize their classroom learning dynamics harmonious with learners’ specific learning situations to advance their autonomous learning behaviors to greater development.
MULTIWORD-LEXIS AND NON LITERAL USES FOUND IN THE GUARDIAN ARTICLE
Authors: Wahyuningtyas Dwi -
Published: February 2023

In mastering vocabulary, language learners often face some challenges, one of which is the occurrences of multiword-lexis and non-literal uses that consist of polysemy, collocation, phrasal verb, idiom, metaphor, and metonymy. This paper will then analyse multiword-lexis and non-literal uses found in a newspaper, the Guardian. Descriptive qualitative research design was employed in this research. The findings showed that there are two (2) occurrences of polysemy, fifteen (15) occurrences of collocation, nine (9) occurrences of phrasal verb, three (3) occurrences of idiom, two (2) occurrences of metaphor, and two (2) occurrences of metonymy with the total thirty three (39) occurrences. The occurrences of non-literal meaning can be grouped into idiom, metaphor, and metonymy.
THE EFFECTIVENESS OF USING ZOOM MEETINGS AND GOOGLE CLASSROOM ON LEARNING ENGLISH IN THE ERA OF THE COVID 19 PANDEMIC
Authors: Suryadi Suryadi
Published: February 2023

The goal of this study was to see how effective Zoom Meetings and Google Classroom are for English language learning in the wake of the Covid 19 pandemic. A survey method is used in the research design. The data for the study was collected using a questionnaire as a data collection tool. A random sample of 53 students was chosen by adjusting the conditions, and the research objective of learning English using Zoom was less effective, with many obstacles encountered, as evidenced by analysis of survey data from respondents, but students believe that learning using Google Classroom was   more effective and simple.  As a result, it can be concluded that using Google Classroom is more effective and preferred by students because it did not deplete the internet. Researchers also recommend that teachers use Google Classroom for online learning during a pandemic.
PLANEJAMENTO DE FÁRMACOS CONTRA COVID-19: UMA EXPERIÊNCIA DE ENSINO REMOTO DE QUÍMICA FARMACÊUTICA
Authors: da Silva Rhanna , Monteiro Larissa , Branco Carlos , Guilhon-Simplicio Fernanda
Published: February 2023

DRUG DESIGN AGAINST COVID-19: A REMOTE TEACHING EXPERIENCE IN PHARMACEUTICAL CHEMISTRY. Infront of with the difficulties faced in making a new drug available to the population, it is essential to seek ways to simplify the process. In silico methodologies are alternatives to benchtop experiments, being frequently used due to their speed and low cost. The present study aimed to formulate a theoretical-practical activity in the Pharmaceutical Chemistry course, where students applied their knowledge of structural modeling and molecular docking to propose bioactive compounds against molecular targets of the SARS-CoV-2 virus. The class was divided, and each group presented a drug candidate, the precursors being natural molecules. In total, seven derivatives were designed and tested against different macromolecules, and then an in silico prediction of their physicochemical characteristics was performed. The docking results were positive for all derivatives, in terms of binding energy, mainly GEND with –9.0 kcal mol-1. In addition, the prototypes exhibited good interactions with the amino acids of the respective targets, mainly KAED, QUED and GEND, in addition to presenting adequate physicochemical properties for meeting the Lipinski restrictions. Therefore, this study presented at least three potential inhibitors of SARS-CoV-2, showing the importance of using computational tools in drug design and development, as well as in teaching practice.
Pre- and postprocessing flood forecasts using Bayesian model averaging
Authors: Hegdahl Trine Jahr , Engeland Kolbjørn , Steinsland Ingelin , Singleton Andrew
Published: February 2023

In this study, pre- and postprocessing of hydrological ensemble forecasts are evaluated with a special focus on floods for 119 Norwegian catchments. Two years of ECMWF ensemble forecasts of temperature and precipitation with a lead time of up to 9 days were used to force the operational hydrological HBV model to establish streamflow forecasts. A Bayesian model averaging processing approach was applied to preprocess temperature and precipitation forecasts and for postprocessing streamflow forecasts. Ensemble streamflow forecasts were generated for eight schemes based on combinations of raw, preprocessed, and postprocessed forecasts. Two datasets were used to evaluate the forecasts: (i) all streamflow forecasts and (ii) forecasts for flood events with streamflow above mean annual flood. Evaluations based on all streamflow data showed that postprocessing improved the forecasts only up to a lead time of 2–3 days, whereas preprocessing temperature and precipitation improved the forecasts for 50–90% of the catchments beyond 3 days' lead time. We found large differences in the ability to issue warnings between spring and autumn floods. Spring floods had predictability for up to 9 days for many events and catchments, whereas the ability to predict autumn floods beyond 3 days was marginal.
Modeling of scour depth and length of a diversion channel flow system with soft computing techniques
Authors: Alomari Nashwan K. , Sihag Parveen , Sami Al-Janabi Ahmed Mohammed , Yusuf Badronnisa
Published: February 2023

This study employed soft computing techniques, namely, support vector machine (SVM) and Gaussian process regression (GPR) techniques, to predict the properties of a scour hole [depth (ds) and length (Ls)] in a diversion channel flow system. The study considered different geometries of diversion channels (angles and bed widths) and different hydraulic conditions. Four kernel function models for each technique (polynomial kernel function, normalized polynomial kernel function, radial basis kernel, and the Pearson VII function kernel) were evaluated in this investigation. Root mean square error (RMSE) values are 8.3949 for training datasets and 11.6922 for testing datasets, confirming that the normalized polynomial kernel function-based GP outperformed other models in predicting Ls. Regarding predicting ds, the polynomial kernel function-based SVM outperforms other models, recording RMSE of 0.5175 for training datasets and 0.6019 for testing datasets. The sensitivity investigation of input parameters shows that the diversion angle had a major influence in predicting Ls and ds.
Guía de aves representativas de Unimagdalena
Authors: García Wilson Tomas , Mendivel Rivas Sergio , Porto Herrera Juan
Published: February 2023

El campus de la Universidad del Magdalena nos confirma cada día que es un oasis en medio de una selva urbana en la ciudad de Santa Marta. Es un lugar de refugio y alimento para animales como reptiles, anfibios, mamíferos y aves. También es un aula abierta que propicia procesos académicos e investigativos para conocer la biología y ecología del patrimonio biológico que se tiene y la importancia de conservarlo. Estos atributos convierten al campus como un escenario para diseñar estrategias divulgativas que permitan afianzar los procesos de enseñanza de la biodiversidad de la región Caribe y al mismo tiempo despertar en la sociedad un interés por mejorar su relación con el medio natural. Con lo anterior en mente, la Facultad de Ciencias Básicas presenta con humildad esta guía de identificación de las aves más predominantes que alberga el campus de la Universidad del Magdalena. Como un ejercicio pedagógico, describe las aves que pueden ser avistadas en cuatro áreas estratégicas: el Bosque Seco, el Lago, las canchas deportivas y la Granja Experimental. Se ilustran 30 piezas fotográficas de aves que se pueden observar en las instalaciones, incluyendo las de cinco nuevos registros de aves en el campus universitario. Además, cada ficha brinda una breve descripción de las especies, datos ecológicos relevantes y su estado de conservación.
Introducción a la biología y microbiología de suelos
Authors: Cruz O´Byrne Rosmery Katherine , Piraneque Gambasica Nelson Virgilio , Aguirre Forero Sonia Esperanza
Published: February 2023

Introducción a la biología y microbiología de suelos presenta una revisión bibliográfica sobre los organismos presentes en los suelos, su rol en la salud y fertilidad del recurso y su esencialidad para la mayoría de los servicios ecosistémicos que hacen posible la vida en la Tierra. Inicialmente, se muestra una visión histórica de la biología y microbiología de suelos, seguida de un reconocimiento del suelo como hábitat, las comunidades que lo conforman y los roles que estas cumplen. Se hace especial énfasis en la microbiota y sus relaciones simbióticas que actúan directamente en los ciclos biogeoquímicos. Por último, se presentan conceptos biológicos en la sostenibilidad del suelo que incluyen los bioindicadores de calidad, las interacciones microbianas y su papel en los agroecosistemas, la regulación climática y las estrategias de conservación para la promoción de la biodiversidad del recurso con énfasis en el trópico seco. A través de este texto se busca contribuir a la concientización sobre la importancia de la biodiversidad del suelo y destacar su papel en la búsqueda de soluciones a las amenazas globales que supone el cambio climático y otras problemáticas actuales, en el marco de los Objetivos de Desarrollo Sostenible (ODS) y los acuerdos multilaterales sobre el medio ambiente (AMUMA).
Armas, fondos y reconocimiento internacional en la Guerra del Pacífico. El papel de la legación del Perú en Francia e Inglaterra tras la caída de Lima (1881-1884)
Authors: Abanto Chani Julio César
Published: February 2023

Esta investigación se centra en conocer las acciones desplegadas por la legación del Perú en Francia e Inglaterra luego de la caída de Lima en poder del ejército chileno y en medio de una profunda anarquía política que influyó en la fijación de los objetivos de la política exterior de los Gobiernos paralelos que tuvo el Perú entre 1881 y 1883, específicamente en la obten­ción de fondos y armamento para los regímenes de los presidentes Francisco García Calderón, Nicolás de Piérola, Lizardo Montero y Miguel Iglesias. A pesar de la profunda división política, la legación peruana continúo con la ejecución de las órdenes de Lima y Arequipa como parte de la política exterior, aunque cada vez con mayor autonomía hacia el final de la guerra. En ese sentido, se analizará información inédita procedente de diversas fuentes históricas, entre ellas los archivos del Ministerio de Relaciones Exteriores del Perú, la Biblioteca Nacional del Perú y el Instituto Riva Agüero de la PUCP.
Clinical case: allogeneic transplantation of hematopoietic stem cells for Fanconi anemia in the onset of refractory anemia with excess blasts
Authors: Prokofiev M. E. , Kostareva I. O. , Sergeenko K. A. , Stepanyan N. G. , Sidorova N. V. , Kirgizov K. I.
Published: February 2023

Fanconi anemia (AF) is a hereditary genetic disease characterized by developmental abnormalities, progressive bone marrow failure, hypersensitivity to alkylating agents, and a tendency to hematological and solid tumors throughout life. The only curative option in the treatment of bone marrow failure in patients with AF is allogeneic hematopoietic stem cell transplantation (allo-HSCT). There are no detailed descriptions of allo-HSCT in patients with AF in the Russian-language literature. On the example of a clinical case with AF at the onset of myelodysplastic syndrome, a choose of method for treating bone marrow failure is presented.
Ultrasound navigation during blockade in children with retinoblastoma with enucleation of the eyeball
Authors: Belousova E. I. , Matinyan N. V. , Tsintsadze A. A. , Kuznetsov D. A. , Kovaleva E. A. , Ushakova T. L. , Panferova T. R. , Polyakov V. G.
Published: February 2023

Introduction. Regional blockades in children in ophthalmology operations are used not only for analgesia in the intra- and postoperative period, but also for the prevention of oculocardial reflex (OCR), postoperative nausea and vomiting (PONV). But there is still no convincing data on the advantages of the methods of retrobulbar blockade (RBB) performed under ultrasound guidance and parabulbar blockade (PBB) performed under ultrasound guidance.   Aim. In the present study, we investigated the efficacy and safety of RBB under ultrasound guidance with ropivacaine 0.5 % for the prevention of OCR and postoperative pain, as well as PONV when detected with PBB of ropivacaine 0.5 % under ultrasound guidance upon detection of enucleation of the eyeball.   Materials and methods. A prospective randomized arterial study was performed for the period 2016–2022. The study included 110 patients with established inclusion criteria. The patients were divided into two groups: 55 patients who performed a RBB + ultrasound and 55 patients who performed a PBB + ultrasound. Evaluated: the likelihood of the introduction of opioid analgesics, the quality of anesthesia, the duration of the block and the likelihood of complications.   Results. There was a decrease in intraoperative diseases in the RBB + ultrasound group, where the average dose of fentanyl was increased by 4.1 ± 1.4 μg/kg, and in the PBB + ultrasound group it was 9.7 ± 1.8 μg/kg (p < 0.05 ). The time to the first frequency of the analgesic in the postoperative period was 6.7 ± 1.8 hours in the PBB + ultrasound group, and 11.7 ± 3.3 hours in the RBB + ultrasound group (p < 0.05).   Conclusions. There was a significant difference in analgesic efficacy between RBB + ultrasound and PBB + ultrasound. It was revealed that RBB + ultrasound reduces intraoperative opioid requirements, stable intraoperative hemodynamics and longer postoperative analgesia. Therefore, the use of RBB + ultrasound for enucleation of the eyeball in children with retinoblastoma is the preferred technique.
Orbital impairment in the debut of oncohematological diseases in children
Authors: Ushakova T. L. , Valiev T. T. , Polyakov V. G. , Artemenko Yu. V. , Panferova T. R. , Malakhova A. A. , Blankova T. I. , Vlasova V. E.
Published: February 2023

Tumor lesion of the orbit is found in the clinic of various oncohematological diseases in children. Untimely referral of such patients to an oncologist delays the timing of the necessary treatment, thereby worsening the prognosis of the disease. The literature review presents the features of clinical manifestations of orbital pathology in children at the onset of acute myeloid leukemia, myeloid sarcoma, lymphoma, Langerhans cell and non-Langerhans cell histiocytosis. The article presents our own observations and identifies factors that negatively affect the timely diagnosis of oncohematological diseases in this category of patients.
Hematopoietic stimulants in the treatment and prevention of graft-versus-host disease
Authors: Shirin A. D. , Vlasenko R. Ya. , Anisimova N. Yu. , Kirgizov K. I. , Valiev T. T. , Stepanyan N. G. , Aliev T. Z. , Morozevich G. E. , Odaryuk O. A. , Filonenko D. V. , Nifantiev N. E. , Novruzov K. M. , Chikileva I. O. , Kiselevskiy M. V.
Published: February 2023

Conditioning regimens prior to hematopoietic stem cell transplantation (HSCT) are often accompanied by a period of aplasia characterized by severe neutropenia, anemia, and thrombocytopenia. Long-term antibacterial and immunosuppressive therapy in patients with graft-versus-host disease (GVHD) exacerbates hematopoietic depression. Colony-stimulating factors, erythropoietins, and thrombopoietin receptor agonists are used to correct hematological dysfunction in these patients. However, these drugs have side effects, and their stimulating effect, as a rule, is limited to one of the hematopoietic lineages. At the same time, in patients after HSCT, for the prevention and treatment of hematopoietic disorders against the background of GVHD, it is necessary to use drugs that promote the restoration of all hematopoietic cell lines. Inducers of Toll- and NOD-like receptors, stimulators of emergency hematopoiesis, can be considered as promising drugs for this category of patients. These compounds include bacterial derivatives and sulfated poly(oligo)saccharides capable of stimulating hematopoiesis, which allows us to consider them as promising stimulants of hematopoiesis for the treatment and prevention of disorders of the immune status and hematopoiesis in GVHD.
Radiation dermatitis: current view on pathogenesis, principles of profilaxis and treatment
Authors: Belysheva T. S. , Valiev T. T. , Shatokhina E. A. , Grigorenko V. A. , Polonskaya A. S. , Kirgizov K. I. , Varfolomeeva S. R.
Published: February 2023

Radiation therapy (RT) is associated with high incidence of dermatologic adverse events. Radiation dermatitis is a major cutaneous side effect of RT. The article presents current views on pathogenesis of radiation dermatitis and modern approaches to prophylaxis and treatment of this cutaneous reaction.
Laparoscopic cytoreductive surgery with hyperthermic chemoperfusion of the abdominal cavity for peritoneal sarcomatosis in a child with embryonal rhabdomyosarcoma. The first Russian experience in pediatric practice
Authors: Akhaladze D. G. , Rabaeva L. L. , Krivonosov A. A. , Merkulov N. N. , Talypov S. R. , Tverdov I. V. , Uskova N. G. , Rabaev G. S. , Grachev N. S.
Published: February 2023

Peritoneal sarcomatosis/carcinomatosis is a rare observation in pediatric practice. It occurs, as a rule, with various sarcomas, sarcomatoid tumors, desmoplastic small round cell tumors. Cytoreductive surgery followed by abdominal chemoperfusion has established itself as an effective method of treating such conditions in adult practice and is gaining popularity in pediatric practice. Laparoscopic cytoreduction followed by hyperthermic chemoperfusion used in adult patients has a number of advantages: early recovery after surgery, reduced hospital days, timely initiation of adjuvant chemotherapy, however, the experience of using a minimally invasive technique in children is limited. The article presents the first clinical observation in Russian practice of a 17-year-old patient with embryonal testicular rhabdomyosarcoma and peritoneal sarcomatosis of the abdominal cavity, which underwent laparoscopic cytoreductive surgery with hyperthermic chemoperfusion.
A Review on the Application of Nanofluids in Enhanced Oil Recovery
Authors: Malika Manjakuppam , Sonawane Shriram
Published: February 2023

Oil mobility has been a significant issue since the recovery of a heavy crude reservoir.
It is determined by two factors: oil rheological properties and penetrability. Nanofluids (NFs) are
a distinct class of engineered fluids characterized by the dispersion of nanoparticles ranging in
size from 1 to 100 nanometers (nm) into a working fluid. They are divided into groups based on
physicochemical characteristics, including nanoparticle morphology, and thermal and rheological
properties. The well-known nanofluids composed of metal (e.g., ZrO2) and ceramic (e.g.,
SiO2) had the best physicochemical performance in terms of oil mobility. This chapter examines
the inundation of metal and nonmetal based nanofluids as a new enhanced oil extraction (EOR)
method for extracting primary and secondary oil from more than 45% of confined reservoir fluids.
Furthermore, new developments in the utilization of these materials on EOR approaches to
combat significant interfacial adhesion across sandstone and fluid interfaces are summarized.
KiOmedine® CM-Chitosan is Effective for Treating Advanced Symptomatic Knee Osteoarthritis up to Six Months Following a Single Intra-Articular Injection: A Post Hoc Analysis of Aproove Clinical Study
Authors: Emans P.J. , Skaliczki G. , Haverkamp D. , Bentin J. , Chausson M. , Schifflers M. , Portelange N.
Published: February 2023

Background:

Symptomatic knee osteoarthritis (OA) is typically treated with hyaluronan-based intra-articular injections. Advanced knee OA patients are often unresponsive to hyaluronan. KiOmedine® Carboxymethyl-Chitosan (CM-Chitosan), a novel fluid implant, was safe and effective for treating symptomatic knee OA.

Objective:

The objective of this study is to describe the efficacy of a single injection of KiOmedine® CM-Chitosan in advanced knee OA.

Methods:

Patients with advanced knee OA enrolled in the APROOVE trial and treated with KiOmedine® CM-Chitosan were identified: subgroup-1, BMI >30 kg/m2 and/or Kellgren Lawrence (KL) grade III (n=39), and subgroup-2, BMI >30 kg/m2 and KL-grade III (n=8). Within-group analyses were performed using the WOMAC scores and OMERACT-OARSI responder criteria at 3 and 6 months.

Results:

In both subgroups, significant improvements in all WOMAC scores were observed at 3 and 6 months (p<0.001 for all comparisons). A high responder rate was observed at 3 and 6 months in subgroup-1 (63.2% and 65.8%) and in subgroup-2 (57.1% and 62.5%).

Conclusion:

This post hoc analysis of the APROOVE trial showed that a single intra-articular injection with KiOmedine® CM-Chitosan could be an effective therapeutic option for patients with advanced knee OA.

Clinical trial registration number: Clinicaltrial.gov

identifier: Net30679208.
Accurate Modeling and Control System Simulation of Bearingless Brushless
DC Motor
Authors: Huang Haoran , Bu Wenshao , Lu Yongfang
Published: February 2023

Background:

Precise modeling and control system design are the basis of highperformance
control of dual-winding bearingless brushless DC motors (BL-BLDCM), and the existing
research is relatively few.

Objective:

This paper takes 12-slot/tooth 4-pole BL-BLDCM as the research object, establishes a set
of a detailed mathematical model, and designs the control system of BL-BLDCM.

Methods:

Firstly, the structure of BL-BLDCM and the radial suspension force generation principle
were introduced. Secondly, a set of an accurate mathematical model of BL-BLDCM was established
which was finally verified by static and dynamic finite element method (FEM), the motor body
model and control system were built by Matlab/Simulink software, and the simulation analysis of
control performance was completed.

Results:

The established mathematical model is correct. The BL-BLDCM can generate stable electromagnetic
torque and radial magnetic suspension force, and the control system has strong ability
of resisting load torque disturbance and radial force load disturbance.

Conclusion:

It has certain reference significance for the accurate modeling and control system design
of later BL-BLDCM.
Validación y adaptación del “Cuestionario de involucramiento en redes sociales digitales (SMEQ)” en población colombiana
Authors: Cano Mariluz , Martin Rodrigo , Gaspar Cartagena Dorimely , Melo Romero Erika Yamila
Published: February 2023

Introduction: In recent years and globally, digital social networks have become one of the main means of communication. This has led to the genesis of a new field of analysis and study regarding the behaviors associated with them. However, many effects related to the use of social networks have been little investigated in the Colombian population. Adjusting research instruments that evaluate the influence of social networks on people is beneficial for understanding associated phenomena. Objective: The purpose of this article is to validate the "Involvement with Digital Social Networks Questionnaire (SMEQ)" in the Colombian population. This instrument is an efficient tool to measure the time people spend on social networks. Method: For the validation, there was a sample of 289 people (71.6% female and 28.4% male), aged between 18 and 62 years (M= 28 years; SD= 10.46), mainly from the city of Medellín (Colombia) and surrounding areas. Results: The findings showed a good model fit (CFI= .99; SRMR= 0.038) and adequate internal consistency (α= .85; ω = .90). Conclusion: The psychometric properties of the SMEQ questionnaire showed adequate values, which would allow its administration in the Colombian context.
Validation of Fluorescence in Situ hybridization (FISH) Assay Using An Analyte-Specific Reagent in Detecting Aneuploidies of Chromosomes 13, 18, 21, X, and Y in Prenatal Diagnosis
Authors: Pahala Ralalage Bhanuka Maheshwara Sisira Kumara , Kaluarachchi Nirmani , Randunu Malshani , Jainulabdeen Munshifa , Nanthakumar Rohini , Vishwakula Sameera , Galhena B. Prasanna
Published: February 2023

Fluorescence In-Situ hybridization (FISH) is a sensitive and highly efficient technique commonly used in routine diagnostics. Most of these tests that use analyte-specific reagents are not approved by US Food and Drug Administration (FDA) but are developed by individual test laboratories. There is an emerging demand for prenatal diagnosis of aneuploidies by FISH. Since most of these assays are laboratory-developed tests, it is essential to validate them prior to their use in diagnosis. However, validation procedures of these assays are oversight despite the presence of several validation guidelines. To validate FISH assay using analyte-specific reagents in detecting aneuploidies of chromosomes 13, 18, 21, X, and Y as per American College of Medical Genetics (ACMG) guidelines in 2016. Analyte-specific reagents supplied by Oxford Gene Technologies were used in the validation process using blood and amniotic fluid samples obtained from healthy male and female adults and fetuses respectively. The validation process includes probe localization, evaluation of assay specificity, and establishment of lower cut-off and reportable reference ranges. Probe localization indicated a 100% specificity for all probes tested. Interphase FISH on uncultured amniotic fluid demonstrated significantly high (≥95%) overall disomic signal patterns for all autosomes and sex chromosomes tested. The reportable 95% confidence interval was 94.84, 94.84, 95.24, 94.54, and 94.54 for chromosomes 13, 18, 21, X, and Y respectively. The present study illustrates an experimental design in validating laboratory-developed FISH assay using analyte-specific reagents in detecting aneuploidies of chromosomes 13, 18, 21, X, and Y as per ACMG guidelines. Test probes used in the present study are consistent with probe localization characteristics, assay specificity, and reportable reference ranges recommended by ACMG. Therefore, the FISH assay used in the present study could be recommended as a supplementary prenatal diagnostic test that can be carried out along with standard chromosomal analysis.
Barriers to and Facilitators of a Blended Cognitive Behavioral Therapy Program for Depression and Anxiety Based on Experiences of University Students: Qualitative Interview Study
Authors: Braun Pia , Atik Ece , Guthardt Lisa , Apolinário-Hagen Jennifer , Schückes Magnus
Published: February 2023

Background

Blended cognitive behavioral therapy (bCBT) programs have been proposed to increase the acceptance and adoption of digital therapeutics (DTx) such as digital health apps. These programs allow for more personalized care by combining regular face-to-face therapy sessions with DTx. However, facilitators of and barriers to the use of DTx in bCBT programs have rarely been examined among students, who are particularly at risk for developing symptoms of depression and anxiety disorders.

Objective

This study aimed to evaluate the facilitators of and barriers to the use of a bCBT program with the elona therapy app among university students with mild to moderate depression or anxiety symptoms.

Methods

Semistructured interviews were conducted via videoconference between January 2022 and April 2022 with 102 students (mean age 23.93, SD 3.63 years; 89/102, 87.2% female) from universities in North Rhine-Westphalia, Germany, after they had completed weekly individual cognitive behavioral therapy sessions (25 minutes each) via videoconference for 6 weeks and regularly used the depression (n=67, 65.7%) or anxiety (n=35, 34.3%) module of the app. The interviews were coded based on grounded theory.

Results

Many participants highlighted the intuitive handling of the app and indicated that they perceived it as a supportive tool between face-to-face sessions. Participants listed other benefits, such as increased self-reflection and disorder-specific knowledge as well as the transfer of the content of therapy sessions into their daily lives. Some stated that they would have benefited from more personalized and interactive tasks. In general, participants mentioned the time requirement, increased use of the smartphone, and the feeling of being left alone with potentially arising emotions while working on tasks for the next therapy session as possible barriers to the use of the app. Data security was not considered a major concern.

Conclusions

Students mostly had positive attitudes toward elona therapy as part of the bCBT program. Our study shows that DTx complementing face-to-face therapy sessions can be perceived as a helpful tool for university students with mild to moderate anxiety or depression symptoms in their daily lives. Future research could elaborate on whether bCBT programs might also be suitable for students with more severe symptoms of mental disorders. In addition, the methods by which such bCBT programs could be incorporated into the university context to reach students in need of psychological support should be explored.