bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of magnetic resonance imaging in the preoperative evaluation of anal fistulas
Authors: Vo Duc , Phan Chien , Nguyen Linh , Le Huyen , Nguyen Tin , Pham Hung
Published: November 2019

This study aimed to determine the role of magnetic resonance imaging (MRI) in diagnosing and describing the characteristics of fistula-in-ano, and the agreement between MRI and operative findings. We conducted a retrospective study in 367 patients with fistula-in-ano who were diagnosed and had an operation at the University Medical Center between January 2016 and January 2018. MRI findings were evaluated and compared with surgical findings using the kappa coefficient (k) method. 367 patients (327 male and 40 female, mean age 39.3 ± 12.4 years). A total of 411 primary fistulas were found during surgery. There was a strong agreement between MRI and surgery for classifying primary tracts (k = 0.89) and detecting secondary tracts (k = 0.94). While the sensitivity and specificity of MRI for detecting internal openings were 99% and 85.2% respectively; these rates were 100% for abscesses. Both T2-weighted turbo spin-echo (T2W TSE) and postcontrast fat-saturated T1-weighted turbo spin-echo (FS T1W TSE) sequences showed high sensitivity (96.6% and 98.4% respectively) and specificity (92.6% and 81.5% respectively) for depicting internal openings and secondary tracts. Post-contrast FS T1W TSE sequence was very effective in detecting abscesses with an accuracy of 100%. In conclusion, MRI can be considered an accurate tool for the preoperative evaluation of fistula-in-ano, which is a major determinant of the surgical outcome. Both T2W TSE and post-contrast FS T1W TSE sequences are highly accurate in depicting the features of fistula-in-ano. If there are no contraindications, contrast administration is recommended to differentiate abscesses from active inflammation.
Flow cytometric identification and cell-line establishment of macrophages in naked mole-rats
Authors: Wada Haruka , Shibata Yuhei , Abe Yurika , Otsuka Ryo , Eguchi Nanami , Kawamura Yoshimi , Oka Kaori , Baghdadi Muhammad , Atsumi Tatsuya , Miura Kyoko , Seino Ken-ichiro
Published: November 2019

Naked mole rats (NMRs) have extraordinarily long lifespans and anti-tumorigenic capability. Recent studies of humans and mice have shown that many age-related diseases, including cancer, are strongly correlated with immunity, and macrophages play particularly important roles in immune regulation. Therefore, NMR macrophages may contribute to their unique phenotypes. However, studies of the roles of macrophages are limited by material restrictions and the lack of an established experimental strategy. In this study, we developed a flow cytometric strategy to identify NMR macrophages. The NMR macrophages were extractable using an off-the-shelf anti-CD11b antibody, M1/70, and forward/side scatter data obtained by flow cytometry. NMR macrophages proliferated in response to human/mouse recombinant M-CSF and engulfedEscherichia coliparticles. Interestingly, the majority of NMR macrophages exhibited co-staining with an anti-NK1.1 antibody, PK136. NK1.1 antigen crosslinking with PK136 results in mouse NK cell stimulation; similarly, NMR macrophages proliferated in response to NK1.1 antibody treatment. Furthermore, we successfully established an NMR macrophage cell line, NPM1, by transduction of Simian virus 40 early region that proliferated indefinitely without cytokines and retained its phagocytotic capacity. The NPM1 would contribute to further studies on the immunity of NMRs.
The intensification of metallic layered phenomena above thunderstorms through the modulation of atmospheric tides
Authors: Yu Bingkun , Xue Xianghui , Kuo Chengling , Lu Gaopeng , Scott Christopher J. , Wu Jianfei , Ma Ju , Dou Xiankang , Gao Qi , Ning Baiqi , Hu Lianhuan , Wang Guojun , Jia Mingjiao , Yu Chao , Qie Xiushu
Published: November 2019

We present a multi-instrument experiment to study the effects of tropospheric thunderstorms on the mesopause region and the lower ionosphere. Sodium (Na) lidar and ionospheric observations by two digital ionospheric sounders are used to study the variation in the neutral metal atoms and metallic ions above thunderstorms. An enhanced ionospheric sporadic E layer with a downward tidal phase is observed followed by a subsequent intensification of neutral Na number density with an increase of 600 cm−3 in the mesosphere. In addition, the Na neutral chemistry and ion-molecule chemistry are considered in a Na chemistry model to simulate the dynamical and chemical coupling processes in the mesosphere and ionosphere above thunderstorms. The enhanced Na layer in the simulation obtained by using the ionospheric observation as input is in agreement with the Na lidar observation. We find that the intensification of metallic layered phenomena above thunderstorms is associated with the atmospheric tides, as a result of the troposphere-mesosphere-ionosphere coupling.
On the emergence of conductivity at SrTiO3-based oxide interfaces – an in-situ study
Authors: von Soosten Merlin , Christensen Dennis. V. , Eom Chang-Beom , Jespersen Thomas. S. , Chen Yunzhong , Pryds Nini
Published: November 2019

Heterostructures and crystal interfaces play a major role in state-of-the-art semiconductor devices and play a central role in the field of oxide electronics. In oxides the link between the microscopic properties of the interfaces and bulk properties of the resulting heterostructures challenge our fundamental understanding. Insights on the early growth stage of interfaces and its influence on resulting physical properties are scarce - typically the information is inferred from post growth characterization. Here, we report on real time measurements of the transport properties of SrTiO3-based heterostructures at room temperature, while the heterostructure is forming. Surprisingly, we detect a conducting interface already at the initial growth stage, much earlier than the well-established critical thickness limit for observing conductivity ex-situ after sample growth. We investigate how the conductivity depends on various physical processes occurring during pulsed laser depositions, including light illumination, particle bombardment by the plasma plume, interactions with the atmosphere and oxygen migration from SrTiO3 to the thin films of varying compositions. We conclude that the conductivity in these room-temperature grown interfaces stem from oxygen vacancies with a concentration determined primarily by a balance between vacancy formation through particle bombardment and interfacial redox reaction and vacancy annihilation through oxidation. Using this approach, we propose a new design tool to control the electrical properties of interfaces in real time during their formation.
Identification of Acinetobacter baumannii and its carbapenem-resistant gene blaOXA-23-like by multiple cross displacement amplification combined with lateral flow biosensor
Authors: Hu Shoukui , Niu Lina , Zhao Fan , Yan Linlin , Nong Jinqing , Wang Chunmei , Gao Naishu , Zhu Xiaoxue , Wu Lei , Bo Tianhui , Wang Hongyu , Gu Jin
Published: November 2019

Acinetobacter baumannii is a frequent cause of the nosocomial infections. Herein, a novel isothermal amplification technique, multiple cross displacement amplification (MCDA) is employed for detecting all A. baumannii strains and identifying the strains harboring blaOXA-23-like gene. The duplex MCDA assay, which targets the pgaD and blaOXA-23-like genes, could identify the A. baumannii isolates and differentiate these isolates harboring blaOXA-23-like gene. The disposable lateral flow biosensors (LFB) were used for analyzing the MCDA products. A total of sixty-eight isolates, include fifty-three A. baumannii strains and fifteen non-A. baumannii strains, were employed to optimize MCDA methods and determine the sensitivity, specificity and feasibility. The optimal reaction condition is found to be 63 °C within 1 h, with limit of detection at 100 fg templates per tube for pgaD and blaOXA-23-like genes in pure cultures. The specificity of this assay is 100%. Moreover, the practical application of the duplex MCDA-LFB assay was evaluated using clinical samples, and the results obtained from duplex MCDA-LFB method were consistent with conventional culture-based technique. In sum, the duplex MCDA-LFB assay appears to be a reliable, rapid and specific technique to detect all A. baumannii strains and identify these strains harboring blaOXA-23-like gene for appropriate antibiotic therapy.
Dengue infection in mice inoculated by the intracerebral route: neuropathological effects and identification of target cells for virus replication
Authors: Amorim J. F. S. , Azevedo A. S. , Costa S. M. , Trindade G. F. , Basílio-de-Oliveira C. A. , Gonçalves A. J. S. , Salomão N. G. , Rabelo K. , Amaral R. , Geraldo L. H. M. , Lima F. R. S. , Mohana-Borges R. , Paes M. V. , Alves A. M. B.
Published: November 2019

Dengue is an important arboviral infection, causing a broad range symptom that varies from life-threatening mild illness to severe clinical manifestations. Recent studies reported the impairment of the central nervous system (CNS) after dengue infection, a characteristic previously considered as atypical and underreported. However, little is known about the neuropathology associated to dengue. Since animal models are important tools for helping to understand the dengue pathogenesis, including neurological damages, the aim of this work was to investigate the effects of intracerebral inoculation of a neuroadapted dengue serotype 2 virus (DENV2) in immunocompetent BALB/c mice, mimicking some aspects of the viral encephalitis. Mice presented neurological morbidity after the 7thday post infection. At the same time, histopathological analysis revealed that DENV2 led to damages in the CNS, such as hemorrhage, reactive gliosis, hyperplastic and hypertrophied microglia, astrocyte proliferation, Purkinje neurons retraction and cellular infiltration around vessels in the pia mater and in neuropil. Viral tropism and replication were detected in resident cells of the brain and cerebellum, such as neurons, astrocyte, microglia and oligodendrocytes. Results suggest that this classical mice model might be useful for analyzing the neurotropic effect of DENV with similarities to what occurs in human.
Phosphoproteomic analysis sheds light on intracellular signaling cascades triggered by Formyl-Peptide Receptor 2
Authors: Cattaneo Fabio , Russo Rosita , Castaldo Martina , Chambery Angela , Zollo Cristiana , Esposito Gabriella , Pedone Paolo Vincenzo , Ammendola Rosario
Published: November 2019

Formyl peptide receptors (FPRs) belong to the family of seven transmembrane Gi-protein coupled receptors (GPCR). FPR2 is considered the most promiscuous member of this family since it recognizes a wide variety of ligands. It plays a crucial role in several physio-pathological processes and different studies highlighted the correlation between its expression and the higher propensity to invasion and metastasis of some cancers. FPR2 stimulation by its synthetic agonist WKYMVm triggers multiple phosphorylations of intracellular signaling molecules, such as ERKs, PKC, PKB, p38MAPK, PI3K, PLC, and of non-signaling proteins, such as p47phox and p67phox which are involved in NADPH oxidase-dependent ROS generation. Biological effects of FPR2 stimulation include intracellular Ca2+ mobilization, cellular proliferation and migration, and wound healing. A systematic analysis of the phosphoproteome in FPR2-stimulated cells has not been yet reported. Herein, we describe a large-scale phosphoproteomic study in WKYMVm-stimulated CaLu-6 cells. By using high resolution MS/MS we identified 290 differentially phosphorylated proteins and 53 unique phosphopeptides mapping on 40 proteins. Phosphorylations on five selected phospho-proteins were further validated by western blotting, confirming their dependence on FPR2 stimulation. Interconnection between some of the signalling readout identified was also evaluated. Furthermore, we show that FPR2 stimulation with two anti-inflammatory agonists induces the phosphorylation of selected differentially phosphorylated proteins, suggesting their role in the resolution of inflammation. These data provide a promising resource for further studies on new signaling networks triggered by FPR2 and on novel molecular drug targets for human diseases.
Local magnetic flux density measurements for temperature control of transient and non-homogeneous processing of steels
Authors: Sorger Gonçalo , Vilaça Pedro , Santos Telmo G.
Published: November 2019

Measuring temperatures during high-temperature processing of steels is usually limited to surface measurements that cannot directly assess the internal temperature distribution. Here, we demonstrate the feasibility of using a magnetic flux density measurement system to assess transient and non-homogeneous temperature fields in a modern high-strength steel, within the intercritical temperature range where microstructural evolution defines their key mechanical properties. The system accurately detects the Curie temperature and distinguishes temperature change rates within the processed volume. The magnetic measurements are also sensitive to the volume above Curie temperature and its shape, as revealed when integrated with thermal computational simulations. The electromagnetic signal provides real-time qualitative and quantitative information relevant to the metallurgical conditions enabling future intelligent control systems for the production and processing of steels. Contactless measurements of temperature-dependent electromagnetic properties can enable through-thickness temperature monitoring solutions, opening up opportunities for non-destructive full-field imaging of steels during thermal and thermomechanical processing.
Isolation distance between municipal solid waste landfills and drinking water wells for bacteria attenuation and safe drinking
Authors: Xiang Rui , Xu Ya , Liu Yu-Qiang , Lei Guo-Yuan , Liu Jing-Cai , Huang Qi-Fei
Published: November 2019

Groundwater pollution and human health risks caused by leachate leakage have become a worldwide environmental problem, and the harm and influence of bacteria in leachate have received increased attention. Setting the isolation distance between landfill sites and groundwater isolation targets is particularly important. Firstly, the intensity model of pollutant leakage source and solute transport model were established for the isolation of pathogenic Escherichia coli. Then, the migration, removal and reduction of bacteria in the aerated zone and ground were simulated. Finally, the isolation distance was calculated based on the acceptable water quality limits, and the influence of hydrogeological arameters was analyzed based on the parameter uncertainty. The results of this study suggest that the isolation distances vary widely ranging from 106 m–5.46 km in sand aquifers, 292 m–13.5 km in gravel aquifers and 2.4–58.7 km in coarse gravel aquifers. The gradient change of groundwater from 0.001 to 0.05 resulted in the isolation distance at the highest gradient position being 2–30 times greater than that at the lowest gradient position. There was a difference in the influence of the thickness of the vadose zone. For example, under the same conditions, with the increase of the thickness of the aeration zone, the isolation distance will be reduced by 1.5–5 times, or under the same thickness of the aeration zone, the isolation distance will be significantly shortened. Accordingly, this needs to be determined based on specific safety isolation requirements. In conclusion, this research has important guiding significance for the environmental safety assessment technology of municipal solid waste landfill.
Predicting novel genomic regions linked to genetic disorders using GWAS and chromosome conformation data – a case study of schizophrenia
Authors: Buxton Daniel S. , Batten Declan J. , Crofts Jonathan J. , Chuzhanova Nadia
Published: November 2019

Genome-wide association studies identified numerous loci harbouring single nucleotide polymorphisms (SNPs) associated with various human diseases, although the causal role of many of them remains unknown. In this paper, we postulate that co-location and shared biological function of novel genes with genes known to associate with a specific phenotype make them potential candidates linked to the same phenotype (“guilt-by-proxy”). We propose a novel network-based approach for predicting candidate genes/genomic regions utilising the knowledge of the 3D architecture of the human genome and GWAS data. As a case study we used a well-studied polygenic disorder ‒ schizophrenia ‒ for which we compiled a comprehensive dataset of SNPs. Our approach revealed 634 novel regions covering ~398 Mb of the human genome and harbouring ~9000 genes. Using various network measures and enrichment analysis, we identified subsets of genes and investigated the plausibility of these genes/regions having an association with schizophrenia using literature search and bioinformatics resources. We identified several genes/regions with previously reported associations with schizophrenia, thus providing proof-of-concept, as well as novel candidates with no prior known associations. This approach has the potential to identify novel genes/genomic regions linked to other polygenic disorders and provide means of aggregating genes/SNPs for further investigation.
Label fusion method combining pixel greyscale probability for brain MR segmentation
Authors: Wang Monan , Li Pengcheng
Published: November 2019

Multi-atlas-based segmentation (MAS) methods have demonstrated superior performance in the field of automatic image segmentation, and label fusion is an important part of MAS methods. In this paper, we propose a label fusion method that incorporates pixel greyscale probability information. The proposed method combines the advantages of label fusion methods based on sparse representation (SRLF) and weighted voting methods using patch similarity weights (PSWV) and introduces pixel greyscale probability information to improve the segmentation accuracy. We apply the proposed method to the segmentation of deep brain tissues in challenging 3D brain MR images from publicly available IBSR datasets, including images of the thalamus, hippocampus, caudate, putamen, pallidum and amygdala. The experimental results show that the proposed method has higher segmentation accuracy and robustness than the related methods. Compared with the state-of-the-art methods, the proposed method obtains the best putamen, pallidum and amygdala segmentation results and hippocampus and caudate segmentation results that are similar to those of the comparison methods.
Serratia liquefaciens FG3 isolated from a metallophyte plant sheds light on the evolution and mechanisms of adaptive traits in extreme environments
Authors: Caneschi Washington Luiz , Sanchez Angélica Bianchini , Felestrino Érica Barbosa , Lemes Camila Gracyelle de Carvalho , Cordeiro Isabella Ferreira , Fonseca Natasha Peixoto , Villa Morghana Marina , Vieira Izadora Tabuso , Moraes Lauro Ângelo Gonçalves , Assis Renata de Almeida Barbosa , do Carmo Flávio Fonseca , Kamino Luciana Hiromi Yoshino , Silva Robson Soares , Ferro Jesus Aparecido , Ferro Maria Inês Tiraboschi , Ferreira Rafael Marini , Santos Vera Lúcia , Silva Ubiana de Cássia Mourão , Almeida Nalvo Franco , Varani Alessandro de Mello , Garcia Camila Carrião Machado , Setubal João Carlos , Moreira Leandro Marcio
Published: November 2019

Serratia liquefaciens strain FG3 (SlFG3), isolated from the flower of Stachytarpheta glabra in the Brazilian ferruginous fields, has distinctive genomic, adaptive, and biotechnological potential. Herein, using a combination of genomics and molecular approaches, we unlocked the evolution of the adaptive traits acquired by S1FG3, which exhibits the second largest chromosome containing the largest conjugative plasmids described for Serratia. Comparative analysis revealed the presence of 18 genomic islands and 311 unique protein families involved in distinct adaptive features. S1FG3 has a diversified repertoire of genes associated with Nonribosomal peptides (NRPs/PKS), a complete and functional cluster related to cellulose synthesis, and an extensive and functional repertoire of oxidative metabolism genes. In addition, S1FG3 possesses a complete pathway related to protocatecuate and chloroaromatic degradation, and a complete repertoire of genes related to DNA repair and protection that includes mechanisms related to UV light tolerance, redox process resistance, and a laterally acquired capacity to protect DNA using phosphorothioation. These findings summarize that SlFG3 is well-adapted to different biotic and abiotic stress situations imposed by extreme conditions associated with ferruginous fields, unlocking the impact of the lateral gene transfer to adjust the genome for extreme environments, and providing insight into the evolution of prokaryotes.
Publisher Correction: Use of reliable contraceptives and its correlates among women participating in Simulated HIV vaccine efficacy trials in key-populations in Uganda
Authors: Abaasa Andrew , Todd Jim , Mayanja Yunia , Price Matt , Fast Patricia E. , Kaleebu Pontiano , Nash Stephen
Published: November 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Comprehensive Analysis of Animal Models of Cardiovascular Disease using Multiscale X-Ray Phase Contrast Tomography
Authors: Dejea Hector , Garcia-Canadilla Patricia , Cook Andrew C. , Guasch Eduard , Zamora Monica , Crispi Fatima , Stampanoni Marco , Bijnens Bart , Bonnin Anne
Published: November 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Introduction – Carbon Capture and Storage
Authors: Bui Mai , Mac Dowell Niall
Published: November 2019

CO2 capture and storage (CCS) and greenhouse gas removal (GGR) are considered vital to meeting global climate change targets. However, despite their technical maturity, their deployment consistently lags behind what is known to be required. This introductory chapter explores why, and suggests some possible paths forward.
CO2 Capture by Adsorption Processes
Authors: Webley P. A. , Danaci D.
Published: November 2019

Adsorption is a reliable process technology that has been in use since the 1960s for gas separation applications. Since the mid 90s, interest has grown around CO2 emissions abatement with adsorption being one of the first technologies considered. There has since been significant research and development on both the materials science, and engineering aspects of adsorption for CO2 capture. Adsorbents with extensive histories such as zeolites, activated carbons, and layered double hydroxides have experienced resurgences, and novel adsorbents such as metal–organic frameworks and microporous organic polymers were conceived. Adsorption-based separations are cyclic processes, and methods to improve the attainable purity and recovery of the CO2 have also been investigated; this work has shown that 90%mol recovery and 95%mol purity are possible for post-combustion capture. Work is also underway to improve the throughput of gas–solid contacting devices as a form of process intensification, which is required for high volumetric flow rate applications. Although there are still some concerns around the stability of some adsorbents to impurities, there have been meaningful and significant advancements over the last 20–25 years. These have made adsorption a viable technology for carbon capture applications.
An Introduction to Subsurface CO2 Storage
Authors: Krevor S. , Blunt M. J. , Trusler J. P. M. , De Simone S.
Published: November 2019

The costs of carbon capture and storage are driven by the capture of CO2 from exhaust streams or the atmosphere. However, its role in climate change mitigation is underpinned by the potential of the vast capacity for storage in subsurface geologic formations. This storage potential is confined to sedimentary rocks, which have substantial porosity and high permeability in comparison to crystalline igneous and metamorphic rocks. These in turn occur in the sedimentary basins of the Earth's continents and near shore. However, the specific capacity for storage is not correlated simply to the existence of a basin. Consideration must also be made of reservoir permeability, caprock integrity, injectivity, fluid dynamics, and geomechanical properties of pressurisation and faulting. These are the topics addressed in this chapter. These processes and properties will combine in complex ways in a wide range of settings to govern the practicality of storing large volumes of CO2. There is clear potential for storage at the scale required to mitigate the worst impacts of global climate change, estimated to be in the order of 10 Gt CO2 per year by 2050. However, until at least dozens of commercial projects have been built in a range of geologic environments, the upper reaches of what can be achieved, and how quickly, will remain uncertain.
Carbon Capture and Utilisation
Authors: Ramírez Ramírez A.
Published: November 2019

The industrial sector is looking for alternative carbon sources able to replace oil and gas in their production processes. Carbon dioxide (CO2) is considered a non-toxic, and abundant C1 feedstock. The term CO2 utilisation describes technologies that use carbon dioxide to provide a service or a product with economic value. This chapter will provide an overview of key potential uses, technological challenges and bottlenecks of CO2 utilisation. Given the broad range of potential CO2 uses, an overview of key uses is provided categorised according to the fate of CO2 in the product: CO2 into fuels/chemicals; CO2 into agglomerates/materials for construction, and CO2 in the subsurface to extract energy sources.
The Political Economy of Carbon Capture and Storage
Authors: Reiner D. M.
Published: November 2019

Most analyses show that deployment of carbon dioxide capture and storage (CCS) technologies is central to any ambitious decarbonisation efforts, but the political economy of developing these technologies has proven to be difficult at the international, national and subnational level. Full-scale projects have recently emerged in several leading countries, but the project pipeline has already slowed, whereas all deployment pathways imagined a rapid scaling up. Rollout has been hampered by economic and scale challenges, the lack of advocates among industry and environmentalists, the perception that the technology was in a zero-sum game for funding with other low-carbon technologies and the lack of robust, long-term government support mechanisms. In rare circumstances, an effective champion has advanced particular projects, but a robust deployment pathway depends on a set of incentive mechanisms that will ultimately enable rollout. Many of the projects that have emerged are not in regions that actively support strong climate action but have done so for a constellation of factors, and may, of course, help drive down costs. Ultimately though, only a shift in the seriousness of wider efforts to address climate change will provide the necessary impetus to change the political economy dynamics that have hampered deployment of CCS.
Getting CO2 Storage Right – Arithmetically and Politically
Authors: Haszeldine R. Stuart
Published: November 2019

Carbon capture and storage (CCS) is proposed as essential in efforts to limit the effects of climate change. CCS is now recognised as “essential, not optional” on the pathway to recover already emitted CO2 and achieve net-negative industrial economies. All aspects of CCS have been established theoretically, experimentally and by pilot trials. The obstacle to deployment is political and economic understanding.
Ruthenium-catalyzed meta-C–H bond alkylation of aryl 2-pyridyl ketones
Authors: Li Gang , Jia Chunqi , Cai Xiaofeng , Zhong Lei , Zou Lei , Cui Xiuling
Published: November 2019

The first example of meta-selective CAr–H bond functionalization of aryl 2-pyridyl ketones has been developed using [Ru(p-cymene)Cl2]2 as the catalyst and alkyl bromide as the coupling reagent.
Polyphosphates can stabilize but also aggregate colloids
Authors: Motta Rayssa Jossanea Brasileiro , Almeida Ana Zélia Falcão , de Lima Bruna Luiza Batista , Schneider Ricardo , Balaban Rosangela de Carvalho , van Duijneveldt Jeroen Sebastiaan , de Oliveira Rodrigo José
Published: November 2019

Long-chain polyphosphates can bridge clay particles leading to new arrested systems: all-inorganic aqueous Wigner glasses. These materials may have use in agriculture and health sciences.
Selective nucleation of ice crystals depending on the inclination angle of nanostructures
Authors: Xu Yangjiangshan , Shen Yizhou , Tao Jie , Lu Yang , Chen Haifeng , Hou Wenqing , Jiang Biao
Published: November 2019

The aim of this work is to reveal a mechanism to explain the ice selective nucleation on special nanostructures and provide a theoretical basis for achieving the regulation of freezing efficiency.
Voltage issue of aqueous rechargeable metal-ion batteries
Authors: Liu Zhuoxin , Huang Yan , Huang Yang , Yang Qi , Li Xinliang , Huang Zhaodong , Zhi Chunyi
Published: November 2019

Working voltage substantially limits the practical applications of batteries. This review emphasizes on the voltage issue of aqueous metal-ion batteries.
Various Cd(ii) coordination polymers induced by carboxylates: multi-functional detection of Fe3+, anions, aspartic acids and bovine serum albumin
Authors: Liu Guocheng , Li Yan , Chi Jie , Xu Na , Wang Xiuli , Lin Hongyan , Chen Baokuan , Li Jianrong
Published: November 2019

Six different Cd(ii) CPs based on a naphthalene–methylene mixed-bridged-amide ligand have been obtained and adjusted by various carboxylates. The multi-functional fluorescence behaviors of these CPs towards Fe3+, CrO42−, Cr2O72−, MnO4−, aspartic acids and BSA were studied.
The distinct role of boron doping in Sn3O4 microspheres for synergistic removal of phenols and Cr(vi) in simulated wastewater
Authors: Yu Changlin , Zeng Debin , Fan Qizhe , Yang Kai , Zeng Julan , Wei Longfong , Yi Junhui , Ji Hongbing
Published: November 2019

Boron doped Sn3O4 microspheres constructed from nanoplates with an unexpected synergistic effect upon simultaneous removal of phenols and Cr(vi) in simulated wastewater.
Removal of chloride ions using a bismuth electrode in capacitive deionization (CDI)
Authors: Chang Junjun , Duan Feng , Su Chunlei , Li Yuping , Cao Hongbin
Published: November 2019

A bismuth–activated carbon (Bi–AC) electrode pair is innovatively packed into a capacitive deionization (CDI) cell to remove chloride ions. Cl removal performance under different voltages and storage–release cycle performance are mainly discussed.
Zn(ii)@TFP-DAQ COF: an efficient mesoporous catalyst for the synthesis ofN-methylated amine and carbamate through chemical fixation of CO2
Authors: Sarkar Priyanka , Chowdhury Arpita Hazra , Riyajuddin Sk. , Biswas Surajit , Ghosh Kaushik , Islam Sk. Manirul
Published: November 2019

SelectiveN-methylation and carbamate formation reactions were demonstratedviathe chemical incorporation of CO2using a Zn-loaded TFP-DAQ COF (covalent organic framework) as an active catalyst under mild reaction conditions.
Chan–Lam N-arylation and C–H amination with heteroaromatic ring-NH: an approach to access extended-fused imidazo[1,2-a]-pyridines/pyrazines
Authors: Guchhait Sankar Kumar , Saini Meenu
Published: November 2019

An arene 1,2-diamination reaction of areneboronic acid with heterocyclic azines mediated by Cu(ii) constructs N-fused imidazole rings.
A MoNiO4 flower-like electrode material for enhanced electrochemical properties via a facile chemical bath deposition method for supercapacitor applications
Authors: Anil Kumar Yedluri , Singh Saurabh , Kulurumotlakatla Dasha Kumar , Kim Hee-Je
Published: November 2019

Schematic representation of the synthesis of MoNiO4 flower-like nanostructures.
Selective targeting of the DEAD-box RNA helicase eukaryotic initiation factor (eIF) 4A by natural products
Authors: Shen Leo , Pelletier Jerry
Published: November 2019

This highlight reviews natural products targeting of the eIF4A RNA helicase by interfering with RNA-binding or acting as interfacial inhibitors to increase RNA resident time.
Color and shape reversible, recoverable and repeatable mechanochromic shape memory polycaprolactone: a single material with dual functions
Authors: Yenpech Nattawat , Intasanta Varol , Tashiro Kohji , Chirachanchai Suwabun
Published: November 2019

A polycaprolactone-based mechanochromic shape memory material exhibits reversible and repeatable shape and color as a result of its crystallinity.
A novel synthetic strategy for hydroxyl-terminated polybutadiene containing high cis-1,4 contents based on a Ni(ii)-coordinated anionic initiating system
Authors: Min Xin
Published: November 2019

In this study, novel hydroxyl-terminated polybutadiene (HTPB) with a high cis-1,4 content was developed using a tert-butyl dimethyl siloxy dimethyl propyl lithium (Li)–naphthenate nickel (Ni)–boron trifluoride (B) initiating system (Li–Ni–B).
Quinoline-triazole hybrids inhibit falcipain-2 and arrest the development ofPlasmodium falciparumat the trophozoite stage
Authors: Singh Anju , Kalamuddin Md , Mohmmed Asif , Malhotra Pawan , Hoda Nasimul
Published: November 2019

The present study involves development of novel quinoline triazole-containing cysteine protease inhibitors which arrest the development ofP. falciparumat the trophozoite stage.
A mechanochemically synthesized porous organic polymer derived CQD/chitosan–graphene composite film electrode for electrochemiluminescence determination of dopamine
Authors: Pan Qianxiu , Xu Zhilu , Deng Shue , Zhang Fenglian , Li Hui , Cheng Yuanzheng , Wei Liuya , Wang Jiangyun , Zhou Baolong
Published: November 2019

CQDs were obtained from a POP derived porous carbon via nitric acid oxidation. CQDs/CG composite film with special properties were fabricated and used for ECL detection of DA in human body fluids.
In silico study on identification of novel MALT1 allosteric inhibitors
Authors: Zhang Jinrui , Ren Li , Wang Ye , Fang Xuexun
Published: November 2019

Paliperidone was screened as an effective and selective drug that can treat MALT1-driven cancer or autoimmune diseases.
Magnetic solid-phase extraction of pyrethroid insecticides from tea infusions using ionic liquid-modified magnetic zeolitic imidazolate framework-8 as an adsorbent
Authors: Huang Xiaodong , Liu Yanan , Liu Huifang , Liu Guangyang , Xu Xiaomin , Li Lingyun , Lv Jun , Gao Haixiang , Xu Donghui
Published: November 2019

A MSPE-GC-MS/MS method was developed for the analysis of pyrethroids from tea infusions using Fe3O4/ZIF-8/IL as an adsorbent.
Adsorption and regeneration of leaf-based biochar for p-nitrophenol adsorption from aqueous solution
Authors: Ma Hongfang , Xu Zhaogui , Wang Wenyu , Gao Xiang , Ma Huifang
Published: November 2019

As an environmentally friendly and low-cost adsorbent, biochar has great potential in wastewater treatment.
Highly efficient microwave synthesis of rhodanine and 2-thiohydantoin derivatives and determination of relationships between their chemical structures and antibacterial activity
Authors: Tejchman Waldemar , Orwat Bartosz , Korona-Głowniak Izabela , Barbasz Anna , Kownacki Ireneusz , Latacz Gniewomir , Handzlik Jadwiga , Żesławska Ewa , Malm Anna
Published: November 2019

An efficient microwave-assisted synthesis of rhodanine and 2-thiohydantoin derivatives, and the correlation between their chemical structure and biological properties is reported.
Bismuthene from sonoelectrochemistry as a superior anode for potassium-ion batteries
Authors: Shen Chao , Cheng Tianle , Liu Chunyan , Huang Lu , Cao Mengyang , Song Ganqiang , Wang Dong , Lu Bingan , Wang Jianwen , Qin Chichu , Huang Xingkang , Peng Ping , Li Xilong , Wu Yingpeng
Published: November 2019

An external force field-assisted electrochemical exfoliation method was adopted to produce few-layered bismuthene nanosheets (FBNs). These FBNs exhibited a high rate performance and ultra-long cycle life for KIBs anode.
Diverse applications of MoO3for high performance organic photovoltaics: fundamentals, processes and optimization strategies
Authors: Gong Yongshuai , Dong Yiman , Zhao Biao , Yu Runnan , Hu Siqian , Tan Zhan'ao
Published: November 2019

This review summarizes the fundamentals, solution processing methods, optimization strategies and various applications of MoO3in OPVs.
A study on regulating the conjugate position of NLO chromophores for reducing the dipole moment and enhancing the electro-optic activities of organic materials
Authors: Zhang Hui , Tian Yanxin , Bo Shuhui , Xiao Linghan , Ao Yuhui , Zhang Ji , Li Ming
Published: November 2019

Adjust the dipole moment of the chromophore by tuning its shape to efficiently transform microscopic nonlinear properties into macroscopic electro-optic activity.
Prostaglandin E1 protects cardiomyocytes against hypoxia-reperfusion induced injury via the miR-21-5p/FASLG axis
Authors: Tang Mingxiang , Pan Hongwei , Zheng Zhaofen , Guo Yin , Peng Jianqiang , Yang Jun , Luo Yangping , He Jin , Yan Sulan , Wang Peng , Zhang Yi , Zhou Yulu
Published: November 2019

Background: Prostaglandin-E1 (PGE1) is a potent vasodilator with anti-inflammatory and antiplatelet effects. However, the mechanism by which PGE1 contributes to the amelioration of cardiac injury remains unclear.

Methods: The present study was designed to investigate how PGE1 protects against hypoxia/reoxygenation (H/R)-induced injuries by regulating microRNA-21-5p (miR-21-5p) and fas ligand (FASLG). Rat H9C2 cells and isolated primary cardiomyocytes were cultured under hypoxic conditions for 6 h (6H, hypoxia for 6 h), and reoxygenated for periods of 6 (6R, reoxygenation for 6 h), 12, and 24 h, respectively. Cells from the 6H/6R group were treated with various doses of PGE1; after which, their levels of viability and apoptosis were detected.

Results: The 6H/6R treatment regimen induced the maximum level of H9C2 cell apoptosis, which was accompanied by the highest levels of Bcl-2-associated X protein (Bax) and cleaved-caspase-3 expression and the lowest level of B-cell lymphoma 2 (Bcl-2) expression. Treatment with PGE1 significantly diminished the cell cytotoxicity and apoptosis induced by the 6H/6R regimen, and also decreased expression of IL-2, IL-6, P-p65, TNF-α, and cleaved-caspase-3. In addition, we proved that PGE1 up-regulated miR-21-5p expression in rat cardiomyocytes exposed to conditions that produce H/R injury. FASLG was a direct target of miR-21-5p, and PGE1 reduced the ability of H/R-injured rat cardiomyocytes to undergo apoptosis by affecting the miR-21-5p/FASLG axis. In addition, we proved that PGE1 could protect primary cardiomyocytes against H/R-induced injuries.

Conclusions: These results indicate that PGE1 exerts cardioprotective effects in H9C2 cells during H/R by regulating the miR-21-5p/FASLG axis.
Construction proposal of hydraulic equipment designed to test hydraulic components and energy carriers
Authors: Nosian Jozef , Markiewicz Marietta , Janoušková Romana , Feriancová Patrícia
Published: November 2019

The aim of the present article is the construction of a device for measuring and testing hydrostatic converters and subsequent verification measurement of the proposed device. This device will allow the measurement and testing of hydraulic pumps under laboratory conditions. In our case, we will test the hydraulic pump UD–25R, which is used in hydraulic drives of agricultural machines. Last but not least, the device described in the article can be used to test individual energy carriers used in hydraulic systems. The described device can simulate conditions that occur in operation. Using verification measurements we have proved that the designed laboratory equipment is suitable for testing hydraulic components and also allows monitoring and testing of the properties of individual hydraulic fluids. The measurement will result in a change in flow rate over time.
Preliminary design of centrifugal compressor using multidisciplinary optimization method
Authors: Shouyi Sun , Zhufeng Yue , Lei Li , Mengchuang Zhang , Weizhu Yang
Published: November 2019

Centrifugal compressor is widely used in turbochargers in which the aerodynamic performance and strength are invariable among the important design objectives. As high pressure ratio centrifugal compressor develops, the interaction between multiple disciplines should be involved in the preliminary design process. A strength prediction method was presented and the prediction error was less than 3% compared with the 3D finite element calculation. The preliminary design method was established with consideration of multidisciplinary couplings. Then, a centrifugal compressor with the lowest pressure ratio of 4.4 was designed based on the method. The optimal results showed that the aerodynamic efficiency increases by 2.245% compared with the initial design results. Finally, the 3D validation was carried out including aerodynamic analysis and strength calculation, which showed good agreement with the optimal results of the preliminary design.
La mise en œuvre d’un plan de prévention des risques technologiques : acceptabilité économiquevsréduction des risques
Authors: Suraud Marie-Gabrielle
Published: November 2019

Ce texte s’intéresse à la loi Bachelot (juillet 2003) et à la mise en œuvre d’un plan de prévention des risques technologiques majeurs (PPRT) dans une zone industrialo-portuaire. D’une part, on peut observer que la notion d’acceptabilité économique, qui permet aux entreprises de faire face aux exigences administratives, est réglementaire mais pas réglementée. En conséquence, la loi destinée à protéger l’industrie et les zones urbaines engendre finalement une tension entre activités économiques Seveso et non Seveso. D’autre part, ce texte montre comment, pour sortir de ce blocage, les décideurs locaux s’engagent dans une démarche d’adaptation de la loi Bachelot que l’État accepte de déformer, à travers des arrangements avec des décideurs locaux.
Interpretation and Validation of Maximum Absorbance Data Obtained from Turbidimetry Analysis of Plasma Clots
Authors: Pieters Marlien , Guthold Martin , Nunes Claudia M. , de Lange Zelda
Published: November 2019

Turbidimetry is used to characterize fibrin clot properties. In purified systems, maximum absorbance (MA) directly relates to fibrin fiber cross-sectional area. However, in plasma samples there are discrepancies in the relationships between MA and fibrinogen concentration, fiber diameter, other clot properties, and cardiovascular disease outcomes, which complicate data interpretation. This study aims to advance understanding of MA of plasma clots through testing how well it relates to fundamental dependence on fibrinogen concentration and fiber diameter as predicted by light scattering theory, other clot properties and lifestyle, and biochemical variables. Plasma samples from 30 apparently healthy individuals with a fibrinogen concentration from 2.4 to 6.4 g/L were included. We performed turbidimetry, permeability, scanning electron microscopy, and rheometry on in vitro formed plasma clots. MA correlated more strongly with fibrinogen concentration (r = 0.65; p < 0.001) than with fiber diameter (r = 0.47; p = 0.01), which combined explained only 46% of the MA variance. Of additional variables measured, only low-density lipoprotein cholesterol correlated with MA (r = 0.46; p = 0.01) and clot lysis (r = 0.62; p < 0.0001) but not with fiber diameter or fibrinogen concentration. MA correlated with clot lysis time (r = 0.59; p = 0.001), storage modulus (r = 0.61; p = 0.001), and loss modulus (r = 0.59; p = 0.001), and negatively with clot permeability (r = –0.60; p = 0.001) also after adjustment for fibrinogen concentration and fiber diameter. Increased MA is indicative of a prothrombotic clot phenotype irrespective of fibrinogen concentration. MA is more indicative of overall clot density than of fiber diameter. Other plasma components can alter internal fiber density without altering fiber diameter and should be considered when interpreting MA of plasma samples.
Secondary Management of Mandible Fractures
Authors: Reddy Likith , Lee Daniel , Vincent Aurora , Shokri Tom , Sokoya Mofiyinfolu , Ducic Yadranko
Published: November 2019

Mandibular fractures are the most common facial fractures that need surgical intervention. If untreated, these fractures affect a patient's occlusion, degree of mouth opening, and facial symmetry, and could cause infection with significant pain. The goal of any surgical intervention is to restore the preinjury occlusion, even if the preinjury occlusion is abnormal. Initial therapies, whether surgical or conservative, are not always successful, however, and revision or delayed surgical intervention can be challenging. Herein, we review common causes of failure of primary surgical management of mandibular fractures and provide tips to successful secondary intervention.
Radiographic Native Femoral Head Size Correlates with Acetabular Cup Size in Primary Total Hip Arthroplasty
Authors: Pfeufer Daniel , Gililland Jeremy , Ajinkya Rane , Duensing Ian , Anderson Mike B. , Peters Christopher L. , Pelt Christopher E.
Published: November 2019

There is very little literature on whether a simple radiographic measurement of native femoral head size correlates with implanted acetabular cup size. We hypothesized that there would be a high correlation between the radiographically measured native femoral head and implanted acetabular component size in primary total hip arthroplasty (THA). We conducted a retrospective study of 277 consecutive patients who underwent primary THA. Patients with prior contralateral THA or a history of congenital deformity were excluded (n = 95). We used the postoperative anteroposterior (AP) pelvic view to calibrate the image using known implanted femoral head component size. We then measured the diameter of the contralateral native femoral head under the assumption that femoral heads are generally symmetrical in patients. Two of the authors performed all measurements. To determine if native femoral head size was correlated with acetabular component size we used the Pearson correlation coefficient (r). There was a high correlation between contralateral native femoral head size and acetabular component size (r = 0.86, 95% confidence interval [CI]: 0.82–0.89). The median difference in radiographically measured native femoral head size and acetabular component size was 7 mm (interquartile range [IQR] = 5–8). Our data showed a high correlation between acetabular component size and radiographically measured contralateral native femoral head size, with the difference being 7 mm. In addition to verifying the actual femoral head size with calipers during surgery, this simple radiographic measurement, which could be done on the affected or contralateral hip, may help surgeons to plan better and improve preoperative templating in primary THA.