bluuebunny/crossref_metadata_2025 huggingface dataset:
An Inpatient Fall Risk Assessment Tool: Application of Machine Learning Models on Intrinsic and Extrinsic Risk Factors
Authors: Jahangiri Sonia , Abdollahi Masoud , Patil Rasika , Rashedi Ehsan , Azadeh-Fard Nasibeh
Published: June 2023

Purpose
This study aimed to identify the most impactful set of intrinsic and extrinsic fall risk factors and develop a data-driven inpatient fall risk assessment tool (FRAT).
Methods
The dataset used for the study comprised in-hospital fall records from 2012 to 2017. Two machine learning (ML) algorithms, Support Vector Machine (SVM) and Random Forest (RF) were utilized to predict the inpatient fall risk level. To enhance the performance of the prediction models, two approaches were implemented, including (1) feature selection to identify the optimal feature set and (2) the development of three distinct shift-wise models. Furthermore, the optimal feature sets in the shift-wise models were extracted.
Results
According to the results, RF outperformed SVM by reaching an accuracy, sensitivity, specificity, and AUC of 0.66, 0.74, 0.59, and 0.73, respectively, considering the full set of features. The performance of the models was further improved (by 3%-5%) by conducting a feature selection process for both RF and SVM models. Specifically, the RF model achieved an accuracy of 0.69 while considering the optimal set of predictors. Moreover, the shift-wise RF models demonstrated higher accuracies (by 4%-10%) compared to the same model using a full feature set.
Conclusion
This study's outcome confirms ML models' compelling capability in developing an inpatient FRAT while considering intrinsic and extrinsic factors. The insight from such models could form a foundation to (1) monitor the inpatients’ fall risk, (2) identify the major factors involved in inpatient falls, and (3) create subject-specific self-care plans.
Plasma GDF15 levels are not modified in response to weight loss induced by liraglutide in patients with type 2 diabetes mellitus
Authors: Straat Maaike , Bizino Maurice , Eyk Huub van , Lamb Hildo J , Smit Johannes , Jazet Ingrid , de Jager Saskia , Boon Mariëtte , Martinez-Tellez Borja , Hoekx Carlijn
Published: June 2023

Objectives
Glucagon-like peptide-1 receptor (GLP-1R) agonists induce weight loss in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is unclear. Recently, the mechanism by which metformin induces weight loss could be explained by an increase in the growth differentiation factor 15 (GDF15), that suppresses appetite. Therefore, we aimed to investigate whether the GLP-1R agonist liraglutide modifies plasma GDF15 levels in patients with T2DM.
Methods
GDF15 levels were measured in plasma samples obtained from Dutch Europids and Dutch South Asians with T2DM before and after 26 weeks of treatment with liraglutide (n = 44) or placebo (n = 50).
Results
Treatment with liraglutide, compared to placebo, decreased body weight, but did not modify plasma GDF15 levels in all patients, or when data were split by ethnicity. Also, the change in plasma GDF15 levels after treatment with liraglutide did not correlate with changes in body weight or HbA1c levels. In addition, the dose of metformin used did not correlate with baseline plasma GDF15 levels.
Conclusion
Compared to placebo, liraglutide treatment for 26 weeks does not modify plasma GDF15 levels in Dutch Europid or South Asian patients with T2DM. Thus, the weight loss induced by liraglutide is likely explained by other mechanisms beyond the GDF15 pathway.
Proteomic landscape of astrocytes and pericytes infected with HIV/SARS-CoV-2 mono/co-infection, impacting on neurological complications
Authors: Acharya Arpan , Ambikan Anoop T , Thurman Michellie , Malik Mohid Reza , Dyavar Shetty Ravi , Végvári Ákos , Neogi Ujjwal , Byrareddy Siddappa N
Published: June 2023

Background
Although most individuals recover from coronavirus disease 2019 (COVID-19) within a few weeks, some people continue to experience a wide range of symptoms known as post-acute sequelae of SARS-CoV-2 (PASC) or long COVID. Majority of patients with PASC develop neurological disorders like brain fog, fatigue, mood swings, sleep disorders, loss of smell and test among others collectively called neuro-PASC. While the people living with HIV (PWH) do not have a higher risk of developing severe disease and mortality/morbidity due to COVID-19. As a large section of PWH suffered from HIV-associated neurocognitive disorders (HAND), it is essential to understand the impact of neuro-PASC on people with HAND. In pursuit of this, we infected HIV/SARS-CoV-2 alone or together in primary human astrocytes and pericytes and performed proteomics to understand the impact of co-infection in the central nervous system.
Methods
Primary human astrocytes and pericytes were infected with SARS-CoV-2 or HIV or HIV + SARS-CoV-2. The concentration of HIV and SARS-CoV-2 genomic RNA in the culture supernatant was quantified using reverse transcriptase quantitative real time polymerase chain reaction (RT-qPCR). This was followed by a quantitative proteomics analysis of mock, HIV, SARS-CoV-2, and HIV + SARS-CoV-2 infected astrocytes and pericytes to understand the impact of the virus in CNS cell types.
Results
Both healthy and HIV-infected astrocytes and pericytes support abortive/low level of SARS-CoV-2 replication. In both mono-infected and co-infected cells, we observe a modest increase in the expression of SARS-CoV-2 host cell entry factors (ACE2, TMPRSS2, NRP1, and TRIM28) and inflammatory mediators (IL-6, TNF-α, IL-1β and IL-18). Quantitative proteomic analysis has identified uniquely regulated pathways in mock vs SARS-CoV-2, mock vs HIV + SARS-CoV-2, and HIV vs HIV + SARS-CoV-2 infected astrocytes and pericytes. The gene set enrichment analysis revealed that the top ten enriched pathways are linked to several neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
Conclusions
Our study emphasizes the significance of long-term monitoring of patients co-infected with HIV and SARS-CoV-2 to detect and understand the development of neurological abnormalities. By unraveling the molecular mechanisms involved, we can identify potential targets for future therapeutic interventions.
Synthesis and Preparation of Nanocomposites of Polyacrylamide Nanofluids in Enhanced Oil Recovery
Authors: Shahbazpanahi Hamid
Published: June 2023

EOR is a process that helps maximize recoverable oil reserves, extend field life and increase recovery rates, and is an important tool for companies to maintain production and increase return on investment. In this article, the performance of nanoclay on aqueous phase viscosity, wettability, and recycled oil in core fluidization in polyacrylamide nanofluid has been investigated in different experiments and EOR. We have used polymers due to the properties of polymers in increasing rheology and effective mobility and controlling stability and variability to resume growth oil in nanofluids. Adding 5% by weight of salt to polymer-clay nanofluid has also been investigated in samples comparable to pure nano clay without salt. The viscosity of this suspension increases by about 50% by adding a certain amount of salt. If the same amount of salt is added to the polymer diluent, the viscosity decreases drastically. The results of the wettability test also show that clay has a better potential to change the wettability in the tendency to salt. In core fluidization tests, the highest efficiency of 30% was obtained in the third recycling in the combination of clay nanoparticles and sulfone copolymer. The highest efficiency was obtained in the third scenario in core fluidization tests, that is; A combination of resin nanoparticles and sulfone copolymer. Their detailed behavior in the characteristics of wettability, rheology, and core fluidization is analyzed in this article.
Dissecting the mechanisms of intestinal immune homeostasis by analyzing T-cell immune response in Crohn's disease and colorectal cancer
Authors: Jiang Tianming , Zheng Jie , Li Nana , Li Xiaodong , He Jixing , Zhou Junde , Sun Boshi , Chi Qiang
Published: June 2023

Background: Maintenance of intestinal immune homeostasis is intricately linked to various immune cells, signaling pathways, and molecular mechanisms. Once the intestinal immune homeostasis is out of balance, it may lead to the occurrence of intestinal diseases. Here, we performed single-cell transcriptome analysis for autologous samples from primary colorectal tumors and Crohn’s disease to disentangle factors shaping the intestinal immune microenvironment.
Results:By aligning T cells across different tissues, we identified various T cell subtypes that maintained immune system homeostasis and were confirmed in enrichment analyses. Next, the pseudo-time trajectory of T cell subclusters was constructed in both syndromes so as to characterize their differentiation patterns and dig out key driver genes. Additionally, cellular communication and transcription factor regulatory networks are all critical components of the intricate web of mechanisms that regulate intestinal immune homeostasis. The complex cellular interaction suggested potential T-lineage immunotherapeutic targets against epithelial cells with high copy number variation level. Finally, regulon networks identified multiple candidates for promising cell-specific transcriptional factors.
Conclusion:This study focused on the immune molecular mechanism under intestinal diseases and contributed into novel insight of depicting a detailed immune landscape and revealing T-cell responding mechanisms in Crohn’s disease and colorectal cancer.
Validation of the Indonesian version of the WHO Self-Reporting Questionnaire (SRQ) – 20: A Psychometric Analysis
Authors: Hasanah Kartika Ayu Safinatunnajjah , Iskandar Shelly , Istiqamah Arifah Nur , Fatmawaty Intan Annisa , Jaya I Gede Nyoman Mindra
Published: June 2023

Background
Per year, mental disorders in Indonesia are increasing because of a lack of early detection and an insufficient number of mental health professionals to detect them early. It is important to minimize these problems by using a simple and valid screening tool for mental disorders. The self-reporting questionnaire 20 has been used regularly in Indonesia to detect symptoms of mental disorders. However, there is limited research on the factors and construct validity of SRQ-20. Thus, this study aimed to assess the factors and construct validity of SRQ-20 developed by the World Health Organization (WHO).
Methods
SRQ-20 data were obtained at random through the public health office’s primary health care program, which encompasses 41,588 individuals. Internal reliability was tested using Cronbach’s alpha. Exploratory factor analysis was used to discover its initial factors. In order to assess whether the SRQ-20 items were correctly employed, factorial validity was performed by utilizing principal component analysis with varimax rotation. Construct validity was done using Confirmatory factor analysis. Discriminant validity was done using the average variance extracted.
Results
The SRQ-20 had good internal consistency and reliability (α = 0.82). Findings of exploratory factor analysis (EFA) revealed three factors for SRQ-20 which are classified based on types of symptoms and have a total variance of 46.03%. The confirmatory factor analysis (CFA) validates EFA findings which revealed each item of SRQ-20 correlates with one another and is robust across the multi-group classification.
Conclusion
The SRQ-20 can be used to screen for mental disorders. The study result provides validated and reliable items on SRQ-20. Further study should be done using different samples and methods across Indonesia.
Interval-valued q-rung orthopair fuzzy Weber operator and its group decision-making application
Authors: Wan Bengting , Wu Zhuocheng , Han Mengjie , Wan MingJun
Published: June 2023

Learning effectiveness evaluation requires the integration of objective test results and the analysis of uncertain subjective evaluations. The methods of the fuzzy theory are applicable to handle the fuzzy information and uncertainty for obtaining more comprehensive and accurate evaluation results. Due to its deflation ability and the representation ability of interval-valued q-rung orthopair fuzzy sets (IVq-ROFSs), the operator of Weber (IVq-ROFW) and the interval-valued q-rung orthopair Weber ordered weighted average (IVq-ROFWOWA) operator are proposed to improve the evaluation in this paper. Firstly, we improve and optimize the Swing algorithm to derive attribute weights. Further, we develop a multi-attribute group decision-making (MAGDM) method for evaluating the learning effectiveness of students based on the IVq-ROFWOWA operator and the Swing algorithm. Lastly, we provide a case to illustrate the application of the proposed MAGDM method. By comparing and analyzing results, we have also shown that the proposed MAGDM method is feasible and effective.
Assessment of the thermodynamics efficiency of a cement vertical raw mill using Aspen Plus and artificial intelligence models
Authors: Okoji Anthony I. , Anozie Ambrose N. , Omoleye James A.
Published: June 2023

Globally, cement plants are striving to improve their energy efficiency. Therefore, it is critical for cement plant operations to increase the monitoring and control of a vertical raw mill energy process. This technology has attracted the interest of the cement industry with its proven benefits in cement grinding applications. A process simulator was used to study an industrial-scale vertical raw mill (VRM) with 65.4% energy efficiency. The paper proposes further a new model based on grid partitioning, sub-clustering, and fuzzy c-means, which incorporates genetic algorithms (GAs) and particle swarm optimizations (PSOs). VRM data from a steady plant process operation, such as raw material output, material moisture, kiln hot gas, mill fan flow, grinding pressure, and separator speed, was used as input to the prediction model. ANFIS-based prediction models are compared with process simulator predictions to determine the most accurate based on prediction performance criteria. Based on the results, the ANFIS model with sub-clustering assimilated with PSO is the most accurate prediction model for VRM energy efficiency. The coefficient of regression (R2) and root mean square error (RMSE) obtained by this model are 0.945 and 1.3006. The results also showed that VRM's energy efficiency decreased from 65.4 to 64.2% when the separator speed increased from 50 to 75 rpm; product particle size on P90µm decreased from 18.2–10.8%. Finally, the proposed ANFIS based model can be considered to be an efficient technique for predicting the energy efficiency of VRM production processes.
Visible light photoredox catalyzed synthesis of tetrahydrobenzofuranone: oxidative [3+2] cycloaddition of dicarbonyl and alkene
Authors: Kartikey kartikey , Jaiswal Deepali , Singh Shailesh , Saquib Mohammad , Singh Santosh , Verma Surya Pratap , Singh Jaya , Singh Jagdamba
Published: June 2023

Visible-light-mediated formation of tetrahydrobenzofuranone by direct oxidative [3 + 2] cycloaddition via coupling between dimedone and chalcone using eosin-Y as a photoredox catalyst has been reported. The reaction takes place by a radical pathway as evidenced from our experiments and literature. The developed method involves the utilization of visible light photoredox catalysis for the formation of C-C and C-O bond in tetrahydrobenzofuranone in one pot procedure. The present protocol shows significant advantages such as the application of visible light as a clean source of energy, green solvent, mild reaction conditions, cost effectiveness, short reaction time, metal free synthesis, high atom economy, and excellent yield.
Enhanced Sentiment Analysis in AI Systems: A Multimodal, Contextual, Privacy-Preserving, and Energy-Efficient Approach
Authors: Farshi A
Published: June 2023

The increasing significance of artificial intelligence in digital communication demands advanced sentiment analysis systems. Current models predominantly focus on text-based data, often struggling with the emotional ambiguity in human communication. To tackle these issues, we introduce a comprehensive sentiment analysis strategy that integrates multimodal data sources, emphasizes context sensitivity, and addresses privacy preservation and energy efficiency. Our approach combines natural language processing, image processing, and audio signal processing to interpret sentiment from textual content, vocal tone, and facial expressions. We leverage context-awareness for precise sentiment interpretation, even in the face of emotionally ambiguous cues. Our model has been extensively validated on various datasets, demonstrating superior performance across diverse contexts. Additionally, our approach implements privacy-preserving mechanisms and is designed for reduced energy consumption, addressing vital aspects in AI application. This work paves the way for more precise, versatile, and responsible sentiment analysis applications across numerous communication environments.
The Diophantine equation Tl = Un - Um
Authors: Tiebekabe P. , Kakanou K. R. , Diouf I.
Published: June 2023

In this paper we focus on Tribonacci numbers Tl which are the difference of two generalized Lucas sequences and solve the Diophantine equation
Tl = Fn - Fm
where Fa is the a-th Fibonacci number.
2020 Mathematics Subject Classification: 11B39, 11J86, 11Y50, 11D61.
Hikâye, Sinema ve Çağdaş Tiyatro Bağlamında Bir Halk Anlatısı: Tahir ile Zühre
Authors: CEYLAN Muhammet Nuri
Published: June 2023

Anlatmaya dayalı türler içinde gerçek ya da gerçeğe yakın olayların aktarıldığı halk hikâyeleri, toplumsal hafızanın yüzyıllar boyunca sonraki kuşaklara bıraktığı kültür mirasları olarak görülmektedir. Bu anlatılar edebî ve tarihî değerleri bakımından son derece kıymetli bir o kadar da zengin bir içeriğe sahiptir. Çalışmada, kültürel bellekte yer etmiş olan Tahir ile Zühre hikâyesi, 1952 yapımı “Tahir ile Zühre” filmi ve çağdaş tiyatro örneği “Tahir ile Zühre” oyunu mukayese edilecektir. Bu karşılaştırmada ilk önce Tahir ile Zühre hikâyesi incelenecek, motifler ve epizotlar bağlamında anlatı aktarılacaktır. Ardından Ömer Lütfi Akad’ın yazdığı ve yönettiği, başrollerini Sezer Sezin ile Kenan Artun'un paylaştığı “Tahir ile Zühre” filminin olay örgüsü sunulacaktır. Son olarak Hayrettin Filiz’in kaleme almış olduğu “Tahir ile Zühre” tiyatrosu bu çerçevede değerlendirildikten sonra anlatıların metinlerarasılık bağlamında uyarlama, esinlenme, yeniden yaratma yönünden mukayesesi yapılacaktır. Anlatının çeşitli formlarda yeniden yazılması etrafında ana motiflerin yeni metinlere yansıması tahlil edilecektir. Çalışmada Tahir ile Zühre hikâyesinin dönüşüm süreci, hikâyeden sinemaya, sinemadan tiyatroya anlatının değişim serüvenini aktarılacaktır.
Postmodern Romanların Anlattığı Masallar: Kırmızı Başlıklı Kız
Authors: SÜRÜCÜ Özlem
Published: June 2023

Alman folklorunun en önemli ürünlerinden biri olan Grimm Masalları, popülaritesi günümüzde de devam eden, zamanla çocuk edebiyatı bağlamından taşarak sanat dallarında da kendini gösteren anlatılardır. Bilhassa Kırmızı Başlıklı Kız, işleniş yönüyle günümüzde sıklıkla çeşitli alanlarda karşılaşılan bir masal hâline gelmiştir. Edebiyatta postmodernizm, metinlerarasılık bağlamında geleneksel veya yazınsal olan her türlü anlatıyı eklektik düşünceden süzerek metne dâhil etme ilkesini benimsemiştir. Bu anlamda yapı itibarıyla olağanüstü unsurlar barındıran folklorik anlatılar, postmodern edebiyatın yaratmaya çalıştığı gerçeklik dünyası bağlamında oldukça elverişli olduğundan postmodern edebiyatla birlikte yeni görünümlerle edebî metinlerde yerlerini almışlardır. Kaynağı mitlere kadar uzanan Kırmızı Başlıklı Kız, içerdiği semboller, motifler, kavramlar ve masal ile sembolleşen soru-cevap zinciriyle oldukça zengin bir anlatı olması sebebiyle popülaritesinin yanı sıra aynı zamanda işlevsel bir masaldır. Bu zenginliği ve işlevselliğiyle postmodern sanatçıların da dikkatini çeken masal, metinlerarası yöntemlerle postmodern eserlere de taşınmış, hem şekil hem de muhteva bağlamında taklit edilen anlatılardan biri olmuştur. Bu çalışmada Türk edebiyatında postmodern anlayışı benimseyen sanatçılardan İhsan Oktay Anar, Şebnem İşigüzel, Nedim Gürsel ve Mine Söğüt gibi isimlerin eserlerinde yer alan Kırmızı Başlıklı Kız masalının işlevi incelenmiştir. Gerek içerdiği sembol ve motifler gerekse bilinçdışı kavramlarıyla Kırmızı Başlıklı Kız masalının romanlara etkileri, sanatçıların başvurdukları metinlerarası yöntemlerin sebep ve sonuçlarıyla birlikte sunulurken masalın bu esnada geçirdiği dönüşüm ele alınmıştır.
Hobbes Felsefesinde Özgürlük Üzerine Beş Önerme
Authors: ÖZTÜRK Armağan
Published: June 2023

Bu çalışmada Hobbes’un özgürlükle ilgili düşünceleri beş önerme

üzerinden temellendirilmiştir. Ontolojik açıdan özgürlüğün

imkansızlığı, özgürlüğün barışa özdeş sayılması, iradenin yokluğu ve

engellerin yokluğu ilkeleri üzerinden özgürlük kavramının

tanımlanması ve son olarak özgürlükle özyönetim arasındaki

bağlantının reddedilmesi bahsi geçen temel tezleri özetler. Makalenin

temel iddiası özgürlük üzerine pek çok meseleyi aynı anda

temellendiren Hobbes’un bireyci doğal hak perspektifinden hiçbir

zaman vazgeçmediği yönündedir. Bu bağlamda devletçi Hobbes’un

negatif özgürlüğü aynı zamanda devlete karşı bir özgürlüktür. Ayrıca

engellerin yokluğu üzerine kavramlaştırma daha sonra negatif

özgürlüğe dönüşecek olan perspektifin ilk halini ortaya koyar. Bu

bağlamda Hobbes’un özgürlüğe bakışıyla negatif özgürlükçü

hassasiyeti benimsemiş liberalizmin özgürlüğe bakışı arasında ciddi

bir paralellik vardır. Düşünürün hukuk ve demokrasi karşıtı

önermeleri ise kamusal alan karşısında özel alana üstünlük tanıyan

bir yorumlama tarzının ürünü gibi durur. Hobbes demokrasi

olmadan da özgürlüğün olabileceğini iddia ederken sadece

döneminin cumhuriyetçi düşünürlerine yanıt vermez aynı zamanda

siyaset ile özgürlük arasındaki bağlantıyı kopararak özgürlüğü doğal

hakkın bir türevi haline getirir.
Azm-zâde İsmail Paşa’nın Azli ve Mallarının Müsaderesi
Authors: KORKMAZ SAMIKIRAN Günay
Published: June 2023

Azm-zâde İsmail Paşa Kudüs, Gazze, Nablus sancaklarının mutasarrıflığında, Trablusşam ve Şam eyaletlerinin valiliğinde bulunmuş, cerdeye başbuğluk yapmış ve hac emirliği yapmış bir şahsiyettir. 1730 İsyanının ardından İsmail Paşa’nın görevine son verilerek hapsine ve mallarının müsaderesine karar verilmiştir. Ayrıca bu azil kararı sadece İsmail Paşa’ya değil Azm-zâde Ailesi’ne de tatbik edilmiştir. Aziller hakkında kaynaklarda farklı gerekçeler ileri sürülse de İsmail Paşa’nın azlini tek bir nedene bağlamak mümkün değildir ve devletin İsmail Paşa için verdiği azil kararındaki maddeler pek ikna edici görünmemektedir. Nihayetinde ise İstanbul’da sükûnetin sağlanmasıyla Şam’da Azm-zâde yönetimi İsmail Paşa’nın kardeşi Süleyman Paşa ile devam etmiştir. Bu da ailenin bölgedeki etkisini göstermesi bakımından önemlidir. Bu çalışma Azm-zâde İsmail Paşa’nın azli meselesine odaklanmakta, müsadere olunan mallarını ve müsadere esnasında yaşanan meseleleri Osmanlı Arşivine ve diğer kaynaklara istinat etmek suretiyle incelemektedir.
Balkan Paktı Süreci’nde II. Balkan Konferansı ve Yankıları
Authors: GEÇİKLİ Recep Murat
Published: June 2023

28 Ocak 1920’de Meclis-i Mebusan’ın kabul ettiği Misak-ı Milli ile tespit edilen ilkeler, Türk dış politikasının temelini oluşturdu. Mustafa Kemal Atatürk, Türkiye’nin çağdaş devletler arasında hak ettiği yeri almasında, izlenecek dış politikanın oldukça etkili olacağını bilmekteydi. Bu bağlamda dış politika vizyonu akılcılık ve gerçekçilik temellerine dayanıyordu. Balkanlar, stratejik özelliklerinden dolayı tarih boyunca büyük devletlerin hedefinde olan bir bölgeydi. Türkiye, Balkanlarda statükocu bir siyaset takip etmekteydi. Balkan devletleriyle sorunların çözümüyle birlikte ikili anlaşmalarla ilişkiler güçlendirilmeye çalışıldı. Türkiye ile Yunanistan arasındaki yakınlaşma Balkanlarda bir birlik kurulması yönünde en umut verici gelişme oldu. Bu doğrultuda konferanslar toplanarak görüşmeler başladı. İlki Atina’da toplanan konferansın ikincisi İstanbul’da toplanmıştı. Çalışmanın amacı; II. Balkan Konferansı öncesinde yapılan hazırlıkları, görüşmeleri, kamuoyunun yaklaşımını ve sonuçlarını ayrıntılı olarak incelemektir. Türk kamuoyunun, konferansı ve dolayısıyla da Balkanlarda bir birlik kurulmasını ne kadar önemsediği arşiv belgeleri, ulusal basın, tetkik eserler ve makalelerden yararlanılarak ortaya çıkarılmaya çalışılmıştır. Yaklaşan II. Dünya Savaşı öncesi Türkiye’nin barıştan yana tavrının konferansta da devam ettiğinin görülmesi ve konferansın yarı-resmi nitelikte olması kamuoyu düşüncesini yansıtması açısından da önemliydi. Bu çalışma; Türkiye’nin resmi dış politika esaslarının kamuoyu ile paralellik gösterdiği ve bu düşüncenin Balkan ülkelerine aksettirilmesinde konferansın etkisini ortaya koymaktadır. Özellikle, ulusal basın ve orijinal arşiv belgelerinden yararlanılarak konunun irdelenmesi bu çalışmayı farklı kılmaktadır.
Effects of employee stock ownership plans on firm performance – evidence from listed commercial banks of Vietnam
Authors: Lan Le Phuong , Thi Thanh Nguyen Hoa
Published: June 2023

This study presents the effect of employee stock ownership plans on the firm performance of joint stock commercial banks in Vietnam. By using the Cobb-Douglas production function model and regression analysis model, combined with the use of financial statement data and Employee Stock Ownership Plan (ESOP) issuance reports of 18 banks listed on Ho Chi Minh and Hanoi stock exchanges from 2015 to 2019, it is found that ESOP had a positive impact on the performance of banks, but there was a lag of about two years. It can be seen that ESOP issuance has a positive effect on the financial ratios of joint stock commercial banks. Especially, the higher the issuance ratio in accordance to the size of a bank, the better the influence on the indices. Though there are many advantages of ESOP compared to traditional bonus programs, only eight joint stock commercial banks in Vietnam have applied ESOP. Banks in particular and businesses in Vietnam in general need to prepare knowledge and resources to expand and promote the true effectiveness of ESOP. From there, some suggestions and recommendations to make the ESOP program really effective for both employees, banks and shareholders will be given.
Polyvinyl Alcohol/Pectin-Based Hydrogel as Sorptive Phase for the Determination of Freely Dissolved Parabens in Urine Samples by LC-DAD
Authors: Marinho Andressa , da Silva Bruno José
Published: June 2023

An extraction phase based on hydrogel disks of polyvinyl alcohol and pectin was developed, characterized, and evaluated for the extraction of four endocrine disruptors (methylparaben, ethylparaben, propylparaben and butylparaben) in free form in human urine samples with subsequent determination by liquid chromatography coupled with a diode array detector (LC-DAD). The proposed hydrogel showed easy synthesis, was made of low-cost and non-toxic polymers, and showed that it has an amphiphilic character. Gels with lower swelling indexes (175%) and more concentrated dispersions of polymers (P20PC2.0) showed lower relative standard deviation (RSD) values. Under optimized solid phase extraction (SPE) conditions, the LC-DAD method presented limits of quantification of 0.1 µg mL-1, accuracy values ranged from 101.3 to 118.2%, while the inter-assay precision ranged from 1.5 to 17.4%. In addition, the polyvinyl alcohol (PVOH)/pectin-based material presented the possibility of reuse of at least 15 times, without presenting carryover effect and physical degradation. In this way, the hydrogel shows promise for the extraction of organic compounds with different polarities in biological matrices.
Insights on mother’s subjective well-being: The influence of emotion regulation, mindfulness, and gratitude
Authors: Warsah Idi , Chamami M. Rikza , Prastuti Endang , Morganna Ruly , Iqbal Mirza Muchammad
Published: June 2023

Adaptation theory explains that mothers’ subjective well-being (SWB) is determined by their abilities to adapt to challenging life events using coping mechanisms. The literature highlights three latent coping mechanism factors: emotional regulation, mindfulness, and gratitude. This study aims to build a model of mothers’ SWB based on these factors. The sample comprised 302 young mothers (20-25 years old) selected using convenience sampling. Data were solicited from Likert scales that measured emotion regulation, mindfulness, gratitude, and SWB and analyzed using structural equation modeling. The results show that the SWB model had adequate goodness of fit, with a chi-square of 153.553 (p .05), GFI of .934, AGFI of .899, CFI of .929, TLI of .906, and RMSEA of .076. The model shows that emotion regulation and mindfulness, mediated by gratitude, influenced SWB, with gratitude as a strong predictor of SWB. As an implication in counseling, gratitude interventions should be applied in practice.
The dynamics of flourishing Indonesian Muslim families: An Interpretative Phenomenological Analysis
Authors: Afiatin Tina , Subandi M. A. , Reginasari Annisa
Published: June 2023

Human flourishing entails a state of complete, intrinsic self-fulfillment; however, the concept also embraces interpersonal interaction through social connection. This research aims to explore the concept and dynamics of flourishing Muslim families. The data collection involved 45 to 120 minutes of in-depth interviews with five participant families. A qualitative approach was taken, with Interpretative Phenomenological Analysis (IPA) and MAXQDA 2020 techniques used to organize the data. We utilized the Ephocé and member-checking and adopted workflow protocol management tools (i.e., MAXQDA 2020) to ensure data credibility. Four super­ordinate themes emerged, namely compassionate love in collaboration; the adaptation process; relatedness to the larger circle beyond nuclear family members; and the role of religious and local wisdom teachings. All the themes were related to establishing the nature of a flourishing family. It is concluded that the meaning of “flourishing family” for the Indonesian Muslim Families participants emphasized shared relational well-being, which is more complex than the simple “human flourishing” concept. The findings contribute to developing the concept of a flourishing family through evidence based on empirical data regarding efforts to maintain positive potential in the family.
Compassionate love parenting training to reduce stress in caregivers of children with special needs: An experimental study
Authors: Desiningrum Dinie Ratri , Hermawati Donna , Somantri Maman , Indriana Yeniar , Rusydana Alhimna
Published: June 2023

Caregivers of children with special needs experience a high workload, which causes stress and low quality of life. A compassionate love attitude amongst caregivers is needed to improve the quality of parenting. This study aims to develop a compassionate love parenting training program to reduce stress among children with special needs caregivers. The method employed was Pre-experimental Design, with One-group Pre-test-Post-test. The research participants were 40 care­givers identified using the purposive sampling technique. In the pre-test, the stress level of the caregivers was measured using the Parental Stress Scale with 24 items (α = .828). The data were analyzed using the Wilcoxon test to observe the differences between the pre-test and post-test of two dependent samples. The results show that the stress score decreased significantly, with Z = -2.023 and with a significance level of .043 .05. It is demonstrated that regular training in compassionate love parenting reduced the stress felt by caregivers of children with special needs. The implementation of compassionate love parenting training in special needs therapeutic centers is important, as it is one of the intervention methods that has been proven to reduce the level of stress to optimize the growth of the child.
The role of psychological capital in flourishing among job seekers: Grit as a mediator
Authors: Wan Sulaiman Wan Shahrazad , Shariff Mohammad Izzat Akmal Bin , Khairudin Rozainee
Published: June 2023

Psychological resources are crucial in enhancing individual potential, yet few studies have focused on positive psychological variables among job seekers. Therefore, the objective of this study is to examine the influence of psychological capital on flourishing, with grit as a mediator. A cross-sectional survey method was employed, with data collected using questionnaires involving 226 participants. Three instruments were included in the questionnaire: the Psychological Capital Questionnaire (PCQ), the Flourishing Scale, and the Short Grit Scale. The data were analyzed using bootstrapping mediation analysis via PROCESS software. The results show that all the psychological capital dimensions (hope, efficacy, resilience, and optimism) significantly influenced grit, with β ranging from .21 to .57 (p .000), and also significantly influenced flourishing, with β ranging from .23 to .40 (p .000). Grit also significantly mediated the psychological capital dimensions and flourishing. These findings indicate that psychological capital, grit and flourishing are important in developing individuals’ potential. It is hoped that they will be useful in designing employability training which incorporates positive psychology resources as intervention modules to assist graduates seeking job opportunities.
Effects of ketamine, midazolam and methadone, combined with local anesthesia, in cats undergoing orchiectomy
Authors: Lima Virgínia Conceição Tavares , Peixoto Anna Julia Rodrigues , Campos Ana Carolina de Souza , Fernandes Maria Eduarda dos Santos Lopes , Gomes Viviane Horta , Coelho Cássia Maria Molinaro
Published: June 2023

Different anesthetic combinations are used for orchiectomy in cats. This study aimed to evaluate the anesthetic and cardiopulmonary effects on the physiological variables of ketamine (10 mg/kg), midazolam (0.2 mg/kg) and methadone (0.3 mg/kg), combined with local anesthesia, in cats undergoing orchiectomy (n = 19 cats). The time for lateral recumbency, degree of sedation, muscle relaxation and nociception were recorded preoperatively. The propofol rescue dose was recorded. The time to head up and quality of recovery were evaluated postoperatively. The time for lateral recumbency was 5 ± 2 minu-tes. Fifteen minutes after the administration of the ketamine-midazolam-methadone combination, a greater sedative effect, muscle relaxation and less response to noxious stimulation were observed. Propofol was administered to twelve cats under local anesthesia, at a total dose of 1.5 ± 0.8 mg/kg. Surgery was started 28 ± 5 minutes after the administration of ketamine--midazolam-methadone combination. There were no differences in the physiological variables evaluated over the other evalu-ation times (p > 0.05). The recovery quality scores were adequate, and the time to head up was 51 ± 10 minutes. Under the conditions of this study, the ketamine-midazolam-methadone combination did not allow local anesthesia for orchiectomy. Many cats required propofol rescue prior to surgery. This combination promoted minimal changes in physiological variables and prolonged anesthetic recovery.
Avaliação do conhecimento e preparo de cirurgiões-dentistas egressos de uma universidade do Sul do Brasil durante a pandemia para o atendimento odontológico em tempos de covid-19
Authors: Marla Kneib Ferri  , Francisco Montagner  , Simone Bonato Luisi  , Tiago André Fontoura de Melo
Published: June 2023

Analisar a atitude de dentistas egressos durante a pandemia em relação à prática profissional iniciada no mercado de trabalho diante da situação atual por covid-19. Material e métodos: Aplicou[1]se um questionário online, por meio da plataforma Google Forms, com 12 questões abertas e fechadas a cirurgiões-dentistas egressos de uma universidade de Odontologia do Sul do Brasil durante a pandemia. O questionário foi estruturado a fim de analisar os cuidados inerentes ao atendimento de pacientes por dentistas que ingressaram no mercado de trabalho durante a pandemia por covid-19. Os dados coletados nos questionários foram transferidos para uma planilha Excel®. A análise dos dados ocorreu por meio de frequência absoluta e relativa. Resultados: A grande maioria dos profissionais realiza os atendimentos odontológicos em consultórios ou clínicas de terceiros (78,6%). Os respondentes relatam que houve modificação no protocolo de desinfecção e controle tanto da equipe de saúde envolvida (71,4%) quanto do ambiente físico (67,9%). Por outro lado, mais da metade dos respondentes admitiu não ter buscado treinamento prévio para enfrentamento da covid-19 (53,6%) e não ter conhecimento se a clínica na qual trabalha realiza um contato prévio com o paciente agendado a fim de saber a sua condição relacionada a covid-19 (57,1%). Conclusão: Os cirurgiões-dentistas recém-formados demonstraram certo grau de conhecimento e preocupação com os cuidados inerentes à desinfecção e ao controle da covid-19 na sua prática clínica tanto em relação à sua equipe de trabalho quanto ao ambiente físico de atendimento.
Reactive Oxygen Species and its Manipulation Strategies in Cancer
Treatment
Authors: Malhotra Kabil , Malik Arzoo , Almalki Waleed H. , Sahebkar Amirhossein , Kesharwani Prashant
Published: June 2023

Cancer is one of the serious diseases of modern times, occurring in all parts of
the world and shows a wide range of effects on the human body. Reactive Oxygen Species
(ROS) such as oxide and superoxide ions have both advantages and disadvantages
during the progression of cancer, dependent on their concentration. It is a necessary part
of the normal cellular mechanisms. Changes in its normal level can cause oncogenesis
and other relatable problems. Metastasis can also be controlled by ROS levels in the tumor
cells, which can be prevented by the use of antioxidants. However, ROS is also used
for the initiation of apoptosis in cells by different mediators. There exists a cycle between
the production of oxygen reactive species, their effect on the genes, role of mitochondria
and the progression of tumors. ROS levels cause DNA damage by the oxidation
process, gene damage, altered expression of the genes and signalling mechanisms. They
finally lead to mitochondrial disability and mutations, resulting in cancer. This review
summarizes the important role and activity of ROS in developing different types of cancers
like cervical, gastric, bladder, liver, colorectal and ovarian cancers.
HPTLC Stability Indicating Analytical Method of Andrographolide and
5-fluorouracil with Network Pharmacology Analysis against Cancer
Authors: Malik Zoya , Parveen Rabea , Zahiruddin Sultan , Gautam Gaurav , Husain Syed Akhtar , Ahmad Sayeed
Published: June 2023

Background:

Herbal drugs when used in combination with chemotherapeutic drugs can
reduce the side effects and increase the efficacy by acting on multiple targets. Andrographolide
(AG), a diterpene lactone isolated from Andrographis paniculata Nees, is a bioactive compound
with anticancer potential, and 5-fluorouracil (FU), a pyrimidine analogue, is used in the treatment
of cancer. Both drugs are used to formulate combination nanoformulation to increase absorption,
thereby increasing their oral bioavailability.

Objective:

The study aimed to develop and validate stability indicating simultaneous HPTLC
method for quantification of FU and AG in combination nanoformulation along with in silico
docking and network pharmacology analysis to understand the interaction between the drugs and
cancer targets.

Methods:

Chromatographic separation was performed using mobile phase chloroform: methanol:
formic acid (9: 0.5: 0.5, v/v/v) on HPTLC silica plates 60 F254 as a stationary phase using UV-Vis
detector and HPTLC scanner at 254 nm. Further, in silico docking analysis was performed to predict
the binding affinity of AG and FU with different proteins and network pharmacology to find
out the exact biomolecular relationship of AG and FU in alleviating cancer.

Results:

The data from the calibration curve showed a good linear regression relationship with r² =
0.9981 (FU) and r² = 0.9977 (AG) in the concentration range of 0.1-2.0 μg/mL. The developed
method was validated according to the ICH guidelines. Stability studies showed changes in peak
patterns and areas. Bioinformatic and network pharmacology analyses of AG and FU with target
proteins and genes associated with cancer play a multimechanistic role in alleviating cancer.

Conclusion:

The developed method has been concluded to be robust, simple, precise, reproducible,
accurate, and stability indicating for simultaneous quantification of AG and FU, and the molecular
interaction studies have further indicated that the combination nanoformulation of AG and FU
could be effective against cancer.
An Optimisation Technique with the Method of Construction for Vehicle Fuel Consumption and Emissions Using Incomplete Block Designs with Some Special Types of Graphs
Authors: Pachamuthu M. , Karthikeyan P. , Kalaiselvi K.
Published: June 2023

Background:

The main key input variables to this optimization technique for constructing incomplete block designs are using bipartite and spanning subgraphs through numerical examples of vehicle fuel consumption and emissions. The theory of graphs plays a significant role in mathematical sciences and engineering technologies. In addition, the graph models many relations and processes in physical, biological, social, and information systems.

Aims and Objectives:

The construction methods using Partially Incomplete Block Designs (PBIBD) with differential equations through bipartite and spanning subgraphs that predict hot stabilized vehicle fuel consumption and emission rates for different drivers using different cars are studied in this paper. The other modelling of fuel consumption and emissions have appeared as an essential tool, which helps to develop and measure vehicle techniques and to help estimate vehicle fuel consumption and emissions. This paper aims to develop an optimization technique for the construction method for incomplete block designs LSD with PBIBD(2) through vehicle fuel consumption and emissions.

Method:

An incomplete block design can be constructed using LSD statistical analysis with bipartite and spanning subgraphs. First, the method for the construction of LSD using bipartite graphs. The second method for the construction of PBIBD(m) using spanning subgraphs. The two construction methods are through numerical examples of an oil company testing five mixings of petrol for fuel efficiency and emission according to the variability of five drivers and five models of cars.

Result:

The inference of the first model of PBIBD(2) using LSD F-value of 0.08 implies the model is not significant (P-values greater than 0.05). The second model has no significant difference between petrol fuel efficiency and emissions. In the third model, there is no significant difference in fuel efficiency between different cars of petrol bunks.

Conclusion:

Finally, it is concluded that the response variable is represented above the maximum quality scores from our fourth driver using a second car to the fourth petrol bunk in fuel efficiency.
Környezeti index és Környezeti Városi Reziliencia Index értékeinek számítása négy Szabolcs-Szatmár-Bereg megyei és négy Győr-Moson-Sopron megyei település esetében
Authors: Greutter-Gregus Éva
Published: June 2023

A globalizáció és az urbanizáció számtalan kihívással állítja szembe a különböző településeket. A globális problémákra az érintettek fenntartható projektek révén igyekeznek gyógyírt nyújtani. A Brundtland Bizottság 1987-es fenntartható fejlődés definíciójának megalkotása óta a fenntarthatósági szemlélet a gazdaság valamennyi dimenzióját átjárja, így a környezeti dimenziót is. Magyarországon az IBM készített tanulmányt (Lados – Horváthné Barsi, 2011), melyben kulcsszerepet kap az élhető város definíciójában meghatározott zöld, fenntartató megoldások keresése. A fenntartható városok sajátságai, hogy ellenállnak a katasztrófáknak, a sokkhatás bekövetkezte után visszatérnek az egyensúlyi állapotba (Seeliger, Turok, 2013). A rezilienciát a fenntarthatóság egyik pilléreként is említhetjük. Az UN-Habitat közleményében úgy fogalmaz a reziliencia bármely városi rendszer azon képességére utal, hogy képes ellenállni többszöri sokkhatásnak és abból gyorsan felépülni, valamint képes fenntartani a szolgáltatásai folytonosságát (OECD, 2018). Tanulmányomban az ország legkeletibb és legnyugatibb megyéje esetében kívánom prezentálni a népességszám alapján kiválasztott négy-négy legnagyobb városuk környezeti indexének és Környezeti Városi Reziliencia Indexének (KVRI) eredményeit, ezzel feltárni az ország keleti és nyugati határánál vizsgált települések helyzetét a környezeti dimenzió vonatkozásában.
Egy szakképző intézmény működésének elemzése az oktatásmenedzsment modellek tükrében
Authors: Ágnes Stomp , Dr. Móré Mariann
Published: June 2023

Az oktatási intézmények működési jellemzőit lényegesen befolyásolják az oktatáspolitikai döntések. Hazánkban 2015. júliusában a Szakképzési Centrumok létrehozásával az iskolarendszerű szakképzés-irányítás új fejezete kezdődött el egy új irányítású szervezeti struktúrában. A szakképző intézmények a szakképzési centrumok részeként jogi személyiséggel rendelkező szervezeti egységekké tagintézményekké váltak. A centralizált irányítás bevezetése az  intézmények, mint oktatási szervezetek működésének keretét és módját jelentős mértékben megváltoztatta, amely hatást gyakorolt a vezetési és irányítási folyamatokra, ezzel az egész szervezet működésére.  Az oktatási intézményekben a gyakorlatban alkalmazott különböző vezetési és irányítási folyamatoknak megfelelően az oktatási intézményeket az oktatásmenedzsment különböző modelljeibe sorolhatjuk, amelynek szakirodalmi elméletét hívjuk segítségül egy szakképző intézmény működésének vizsgálatában. Tanulmányunk célja egy szakképző intézmény működésének vizsgálata az oktatásmenedzsment modellek tükrében. A szakképző intézmény működését a Szabolcs-Szatmár-Bereg megyében működő egyik Szakképzési Centrum és annak egyik tagintézménye esetében vizsgáljuk. Tanulmányunk a dokumentumelemzés módszerére épül. Az elemzés során a vizsgált intézmények dokumentumainak elemzését a szakirodalomban meghatározott oktatásmenedzsment modellek kulcsfontosságú dimenzióinak egyes jellemzői szerint végeztük el. Az elemzés eredménye egy átfogó képet ad a vizsgált szakképző intézmény irányításának jellegéről és természetéről.
A Debreceni Egyetem vezetés és szervezés mesterszakos hallgatóinak tanulási motivációra irányuló vizsgálata
Authors: Hajdu Franciska , Barizsné Hadházi Edit , Kotsis Ágnes
Published: June 2023

Tanulmányunk célja a felnőttkori tanulás témakörének bemutatása. Ennek érdekében először meghatározzuk a tanulás definícióit és fontosságát az ember életében. Ezt követően kitérünk a felnőtt korban történő tanulás történelmi hátterére és alakulására. Bemutatásra kerül a felnőttkori tanulás motivációja különböző motivációs elméletek függvényében. A tanulmány második felében egy kezdeti kutatás kerül bemutatásra, melynek középpontjában a felnőttkori tanulás motivációja áll.  Kutatásunk alanyai fiatal felnőttek, akik a Debreceni Egyetem Gazdaságtudományi Karának vezetés és szervezés mesterszakán folytatják tanulmányaikat. Arra szeretnénk válaszokat kapni, hogy a különböző tényezők milyen mértékben motiválják a fiatal felnőtteket tanulmányaik során. Az eredményekkel képet szeretnénk adni mind az oktatók, mind a versenyszférában dolgozó humánpolitikai szakembereknek arról, hogy miképp jellemezhető a vizsgált hallgatók tanulási motivációja. A kutatást a későbbiekben nagyobb mintára is kívánjuk majd kibővíteni.
Оптические и лазерные характеристики Yb:YSAG-керамики
Authors: Жмыхов В.Ю. , Гурьев Д.А. , Цветков В.С. , Добрецова Е.А. , Пырков Ю.Н. , Кузнецов С.В. , Никова М.С. , Тарала В.А. , Вакалов Д.С. , Кравцов А.А. , Цветков В.Б.
Published: June 2023

The optical and generation characteristics of 8.3(3) at. % Yb:YSAG ceramics (Y2,55Yb0,25Sc1,00Al4,2O12) made by solid solution powder sintering. Lasing was obtained on the basis of Yb:YSAG ceramics and the characteristics of laser radiation were studied at different transmittances of the output mirror of the resonator. The maximum generation power was 1.8 W at 3.6 W of absorbed pumping in the quasi-cw generation mode. The maximum differential efficiency was 57% for a mirror with a transmittance of 14.5%.