bluuebunny/crossref_metadata_2025 huggingface dataset:
Cursos abertos on-line: um cenário para a gestão pessoal do conhecimento?
Authors: Fonseca Diego Ernesto Leal
Published: February 2020

A partir de uma discussão dos antecedentes e características dos cursos on-line, este artigo descreve uma solução tecnológica de apoio à realização deste tipo de curso, baseada no uso de ferramentas públicas e de uso gratuito(isto é, que não requerem instalação em um servidor próprio). Esta é uma prova de conceito que busca evidenciar as possibilidades e obstáculos associados à oferta deste tipo de prática educativa em um contexto latino-americano.Palavras-chave: educação aberta; cursos abertos on-line; gestão pessoal do conhecimento
Reestruturação e expansão do ensino superior público: o programa Reuni na Universidade Federal do Ceará sob a visão dos alunos
Authors: Cabral Augusto Cézar de Aquino , Romero Claudia Buhamra Abreu , Penha Emanuel Diego dos Santos , Penha Emanuel Dheison dos Santos , Alves Rafael de Almeida , Parente Tobias Coutinho
Published: February 2020

Com a instituição do Programa de Apoio ao Plano de Reestruturação e Expansão das Universidades Federais (Reuni), o governo federal tenta criar condições para ampliar o acesso e a permanência dos estudantes na educação superior. Nesse contexto, esta pesquisa objetiva investigar a percepção dos estudantes dos dez centros acadêmicos da Universidade Federal do Ceará (UFC), regularmente matriculados no 2° semestre de 2008, em relação ao Reuni e à proposta de adesão da UFC ao mencionado programa, a partir de uma perspectiva mercadológica. Para a determinação da amostra de entrevistados foi utilizada a fórmula de Cochran, para populações finitas, e amostras aleatórias estratificadas, resultando em uma amostra de 378 estudantes para um nível de confiança de 95%. Foram utilizadas variáveis que influenciam o comportamento do público-alvo, tais como renda, grupo social e idade, com foco no marketing educacional. Trata-se de uma pesquisa quantitativa quanto à sua natureza, descritiva quanto aos fins e realizada mediante survey. Constatou-se grande desconhecimento sobre o Reuni – 50,5% dos entrevistados nunca ouviram falar sobre o programa. Percebeu-se ainda que os estudantes que possuem uma atitude negativa sobre o Reuni aprovam o conteúdo da proposta da UFC, da mesma maneira que os estudantes que não possuem essa atitude.Palavras chave: Ensino Superior, Formação de Opinião, Reuni.
Intervenção estatal, centralização política e reforma burocrática: o significado dos Departamentos Administrativos no Estado Novo
Authors: Codato Adriano
Published: February 2020

O objetivo deste artigo é expor e explicar um momento específico da evolução político-institucional brasileira. São explorados os conflitos que estão na origem da escolha e a implementação de uma nova ordem político-administrativa no pós-1930. São examinadas as origens, a concepção e os objetivos que guiaram a invenção de um aparelho burocrático que, juntamente com o interventor federal, não só controlou as elites políticas regionais, mas também contribuiu para a organização do poder do Estado em bases nacionais, cooperando para viabilizar a capacidade estatal: os Departamentos Administrativos. Analiso o contexto político, os antecedentes legais e as inovações institucionais do decreto-lei nº 1202/39, a fim de responder a duas questões bem específicas: por que e com que objetivo essa lei sobre a administração dos estados e dos municípios foi criada durante o Estado Novo?Palavras-chave: Departamento Administrativo; Governo Vargas; administração pública.
O aperfeiçoamento dos servidores do Estado
Authors: De Magalhães Celso
Published: February 2020

Texto publicado na RSP, vol. 2, no 3, de junho de 1942
Reflexões sobre a atuação da Advocacia-Geral da União em projetos de geração de energia hidrelétrica
Authors: Vaz Tania Patricia de Lara
Published: February 2020

O presente trabalho contém algumas reflexões sobre o papel da advocacia de Estado, na qual está inserida a Advocacia-Geral da União e seus membros de carreira, no desenvolvimento e na implementação de políticas públicas e projetos do governo federal brasileiro, especificamente sob o enfoque da gestão pública e dos movimentos de modernização do Estado e reformulação do modelo burocrático. Com foco na fase de modelagem do leilão para compra de energia elétrica proveniente da Usina Hidrelétrica de Jirau, licitada de acordo com o novo modelo do setor elétrico, examina-se a atuação do órgão de consultoria e assessoramento jurídico do Ministério de Minas e Energia e o papel que desempenha.Palavras-chaves: disfunções burocráticas, Advocacia-Geral da União, setor elétrico.
Contribuições do escritório de gerenciamento de projetos públicos na gestão para resultados
Authors: Pinheiro Marcelo Torres , Silva Mônica Aparecida da Rocha
Published: February 2020

Gerenciamento de projetos (GP) e gestão para resultados (GpR) são temas que vêm ganhando espaço nas administrações públicas. Entre as recomendações do modelo aberto de gestão para resultados do Banco Interamericano de Desenvolvimento (BID) e do Centro Latinoamericano de Administração para Desenvolvimento (Clad), está a gestão de programas e projetos. A interação entre tais temas instigou o trabalho de pesquisa, que teve o propósito de compreender a sinergia entre a metodologia de GP do Project Management Institute e o referido modelo aberto, ou seja, de que maneira técnicas, processos e ferramentas de gerenciamento de projetos contribuem para a GpR. As relações foram pesquisadas a partir de três escritórios de gerenciamento de projetos (EGP) de governos estaduais. Com base no método hipotético-dedutivo foram aplicados questionários, realizadas entrevistas e coletados materiais in loco. Os EGP, apesar de possuírem funções correlatas, têm especificidades distintas. Os resultados da investigação sugerem que o GP impacta no processo de planejamento e implementação de políticas públicas, atuando, sobretudo, na melhoria da eficiência e da eficácia das práticas da gestão governamental.Palavras-chave: Gerenciamento de projetos públicos, gestão para resultados, implementação de políticas públicas
O desempenho individual de gestores intermédios da administração pública portuguesa
Authors: Brandão Catarina , Jordão Filomena
Published: February 2020

Este estudo de caso foca o desempenho individual (DI) de gestores intermédios da Administração Pública Portuguesa, procurando clarificar a estrutura interna do seu DI, considerando as dimensões de desempenho de tarefa e contextual, propostas por Borman e Motowidlo (1993, 1997). Neste sentido, recolheu-se informação junto a dirigentes intermédios e seus supervisores em uma organização do setor de Educação, recorrendo a entrevistas semiestruturadas e diários de bordo, e submeteu-se a informação recolhida à análise de conteúdo. O discurso dos participantes permite perceber que reconhecem a natureza multidimensional do DI dos gestores intermédios, possuindo uma concepção mais diferenciada em nível de desempenho de tarefa. Sugere ainda a pertinência de promover nestes gestores a valorização e adoção de comportamentos de formação e desenvolvimento de subordinados, de delegação, de planeamento e organização, bem como de provimento de pessoal, na medida em que estes comportamentos, quando adotados por gestores de linha, traduzem uma prática de trabalho de desempenho elevado.Palavras-chave: Desempenho individual; Desempenho de tarefa e contextual; Gestores intermédios da Administração Pública.
Orçamento e desempenho municipal: uma análise comparada da qualidade do gasto público nas políticas sociais
Authors: Cavalcante Pedro , Lariu Cecília
Published: February 2020

O pressuposto da pesquisa é que as prefeituras que mais investem tendem a possuir melhores condições para a implementação de uma política pública, ou seja, quanto maior os dispêndios orçamentários dos governos, mais efetivos serão os seus desempenhos na provisão dos serviços públicos. A fim de avaliar esse postulado, o presente artigo objetiva investigar a qualidade dos gastos públicos mediante a análise da relação entre a execução orçamentária nas políticas de saúde, educação e assistência social e a efetividade das prefeituras na estruturação e provisão dos serviços. Os resultados indicam a existência de sérios problemas acerca da qualidade dos gastos nas políticas sociais brasileiras, na medida em que, em todos os seis casos analisados, prevalecem relações lineares fracas ou nulas entre o dispêndio orçamentário, a capacidade administrativa e a provisão de serviços públicos, divergindo, portanto, da premissa original do estudo.Palavras-chave: Qualidade de gasto; Política social; Governos municipais
O modelo de gestão pública por resultados em Minas Gerais analisado à luz da experiência do Programa Estado para Resultados
Authors: Bechelaine Cinthia Helena de Oliveira , Silveira Mauro César da , Neves Camila Barbosa
Published: February 2020

O presente trabalho almeja investigar o processo de desenvolvimento da gestão por resultados em Minas Gerais, marca da segunda geração de políticas mineira intitulada Choque de Gestão. Em termos específicos, objetiva-se analisar o Programa Estado para Resultados (EpR), sua composição, processo de construção e estrutura de funcionamento. Como método de pesquisa, utilizou-se a grounded theory, traduzida por teoria fundamentada nos dados e apresentada como uma alternativa para pesquisas qualitativas sobre fenômenos organizacionais. Apresenta-se uma discussão teórica que visa a definir o conceito de gestão pública por resultados, cuja finalidade é a criação de valor público. As implicações dessa discussão são ilustradas e problematizadas em um estudo de caso do EpR, à luz de seus antecedentes. Por fim, conclui-se que o EpR constitui um modelo híbrido e particular da gestão por resultados mineira que visa, essencialmente, a consecução da estratégia de governo e o suporte aos processos de tomada de decisões no estado.Palavras-chave: Gestão; público; resultados
Diretrizes para implantação da governança de tecnologia da informação no setor público brasileiro à luz da Teoria Institucional
Authors: Rodrigues José Geraldo Loureiro , Neto João Souza
Published: February 2020

Neste trabalho, foi desenvolvido um conjunto de diretrizes que, de forma sustentável, possibilitam a introdução de boas práticas e procedimentos de governança de TI na administração pública federal (APF), transpondo as dificuldades inerentes aos processos de mudança no setor público. Para tanto, foi estabelecida uma metodologia de pesquisa que contemplou o levantamento bibliográfico dos conceitos de governança corporativa, governança de TI, gerenciamento da área de TI, no âmbito do setor privado e do setor público, e das teorias organizacionais, para identificação de explicações aplicáveis aos processos de mudança no setor público. Também se submeteu um questionário aos gestores de TI das principais organizações da APF, para identificação do nível de conformidade com as recomendações do TCU, consubstanciadas nos acórdãos 1603/2008, 2308/2010 e 2584/2012, e das possíveis causas que levaram ao cumprimento ou descumprimento dessas recomendações. Por fim, estabeleceram-se orientações básicas para implantação da governança de TI no setor público brasileiro, que considerou as características institucionais dos órgãos públicos e a tendência à homogeneização por meio do isomorfismo mimético, normativo e coercitivo, proposto em postulados da Teoria Institucional.Palavras-chave: governança de tecnologia da informação; setor público; Teoria Institucional
Desenvolvimento da teoria de administração democrática
Authors: Waldo Dwight
Published: February 2020

Dwight Waldo (Tradução de Renata dos Santos Costa;Revisão técnica de João Alberto Tomacheski)A RSP Revisitada disponibilizou, em sua edição anterior, a primeira parte do texto de Dwight Waldo (1913-2000), Desenvolvimento da Teoria de Administração Democrática, clássico publicado em março de 1952, na American Political Science Review. Após cerca de 60 anos, esta seção resgata a continuação do ensaio, suprimida quando de sua publicação na edição de 1953 da RSP. O texto apresenta as bases do pensamento e da história administrativa, diante das quais as teorias da administração democrática poderiam ser vistas em relevo. O artigo passa em revista algumas dessas teorias e autores e reflete sobre perspectivas e problemas do desenvolvimento da teoria da administração democrática.Sendo a administração o centro do governo moderno, os conceitos democráticos do século 20 foram forjados no sentido de compreender a gestão administrativa. Desta feita, as teses sobre administração democrática, elaboradas entre as décadas de 1940 e 1950, representavam significativo progresso no pensamento político e foram construídas com intuito de se buscar novos caminhos na evolução das doutrinas democráticas.O ensaio destaca as diversas linhas que o pensamento sobre a democracia e a administração vinha seguindo. Existia, sem dúvida, considerável literatura a cruzar para as velhas divisas entre política e administração, e também a procurar uma adaptação entre a administração e as necessidades da democracia em meados do século 20.
Políticas públicas e relações federativas: o Sistema Nacional de Cultura como arranjo institucional de coordenação e cooperação intergovernamental
Authors: Da Silva Adélia Cristina Zimbrão da Silva
Published: February 2020

Este texto tem o objetivo de analisar o projeto do Sistema Nacional de Cultura balizado por questões referentes às relações federativas e à descentralização de políticas públicas. Para esse intento, toma como base a conceituação política regulada e não regulada, elaborada por Marta Arretche para distinguir relações intergovernamentais central-local atinentes à autoridade sobre a formulação e sobre a execução de políticas públicas. Examina-se a configuração institucional de articulação e compartilhamento interfederativo de políticas públicas de cultura presente na proposta dessa política cultural, tendo como referência o Sistema Único de Saúde. Arranjos com mecanismos institucionais que induzam e regulem a execução descentralizada, como o proposto no Sistema Nacional de Cultura, parecem ser uma condição para mobilizar e vincular estados e municípios em torno das políticas públicas de cultura. A aposta é de que espaços institucionalizados de negociação e pactuação podem proporcionar melhorias no diálogo e na cooperação entre os entes federados, para o desenvolvimento de ações governamentais na área cultural.Palavras-chave: Políticas públicas de cultura; Sistema Nacional de Cultura; relações federativas
Mecanismos da construção federal da intersetorialidade no Programa Bolsa Família: o papel das burocracias
Authors: Da Silva Lucas Ambrózio Lopes
Published: February 2020

São descritos e analisados os mecanismos pelos quais a intersetorialidade é construída no Programa Bolsa Família (PBF) no nível federal. Embora a tarefa de conferir intersetorialidade ao programa seja compartilhada entre União e Municípios, principalmente, este trabalho enfocará a dinâmica de ação do Governo Federal, procurando entender como este tem construído a intersetorialidade. São apresentados mecanismos organizacionais e estratégias políticas mobilizadas com distintas consequências sobre o elevado grau da instersetorialidade construída. A atuação do Governo Federal vai muito além da formulação e do lançamento das diretrizes para o programa. Entre os distintos mecanismos e estratégias descritos, um deles destaca-se: a forte capacidade de mobilização e empoderamento de uma sólida burocracia, com alto potencial de coordenação intersetorial e alto compromisso político com os objetivos do programa. Analisa-se como os elementos dessa escolha e desse processo de empoderamento da burocracia, principalmente da burocracia de nível médio (nível hierárquico intermediário), têm levado à superação de obstáculos concretos e potenciais, imprimindo elevado nível de intersetorialidade ao PBF no que diz respeito à ação do Governo Federal, que também tem exercido poder de indução nos governos subnacionais.Palavras-chave: Programa Bolsa Família; intersetorialidade; burocracia
A revolução da informática chega à administração
Authors: Filho Paulo Jobim
Published: February 2020

Texto publicado na RSP, vol. 113, nº 1, março de 1985.
Patient portals and quality of care: A literature review using the BC Health Quality Matrix (Preprint)
Authors: Black Alanna , Le Cathy , Barnett Jeffrey , Tsai Wan-Yun , Sangha Shawn , Montgomery Jennifer
Published: February 2020

BACKGROUND

Electronic patient portals in healthcare are quickly becoming the preference of clinicians, patients, and caregivers alike. In times where the demand for all things to be online appears limitless, it is no surprise that portals are requested when updating health information systems worldwide. However, there are barriers to implementing online portals and many countries are lagging behind in updating their systems. With the interest in increasing investment in online portals by the Canadian public healthcare system, decision makers should be considering whether patient access to medical records through portals and mobile devices provides any changes to quality of care.

OBJECTIVE

This literature review examines available research in Canada and globally on health-related online portals and their impact on quality of care and patient access. Also examined are examples of different health portals, including issues or barriers to full implementation and utilization in the health sphere.

METHODS

A preliminary search was completed in May 2019 to examine the impact of patient portals on quality of care. The resources utilized in the first stage of the review included the University of British Columbia and the Western University library databases, Google, and Google Scholar. Parameters for the search included search terms such as patient portals, personal health records, effectiveness, quality, and access. Recent articles were prioritized, and included articles were generally published in the last five years. The authors reviewed 52 articles or article abstracts and 29 were included in the current review. Of the mixture of Canadian and international references, five are systematic reviews, and 18 are original research studies.

RESULTS

This study reviewed the available literature and found that there are some positive trends on patient portals’ impact on quality of care, with overall inconclusive or neutral results. Emerging evidence has showcased some benefits of implementing electronic health and patient portals to improve the quality of patient care and access to pertinent health records. However, general consensus is that there is limited available literature that is not considered to be outdated and as such, further investigation is required to support any previous findings.

CONCLUSIONS

As health care related technology develops further, better quality, quantity, and larger-scale studies will be available in evidence-based research databases. As such, a future follow-up literature review would be relevant to re-examine this topic.
Wikipedia in Vascular Surgery Medical Education: Comparative Study (Preprint)
Authors: Yacob Michael , Lotfi Shamim , Tang Shannon , Jetty Prasad
Published: February 2020

BACKGROUND

Medical students commonly refer to Wikipedia as their preferred online resource for medical information. The quality and readability of articles about common vascular disorders on Wikipedia has not been evaluated or compared against a standard textbook of surgery.

OBJECTIVE

The aims of this study were to (1) compare the quality of Wikipedia articles to that of equivalent chapters in a standard undergraduate medical textbook of surgery, (2) identify any errors of omission in either resource, and (3) compare the readability of both resources using validated ease-of-reading and grade-level tools.

METHODS

Using the Medical Council of Canada Objectives for the Qualifying Examination, 8 fundamental topics of vascular surgery were chosen. The articles were found on Wikipedia using Wikipedia’s native search engine. The equivalent chapters were identified in Schwartz Principles of Surgery (ninth edition). Medical learners (n=2) assessed each of the texts on their original platforms to independently evaluate readability, quality, and errors of omission. Readability was evaluated with Flesch Reading Ease scores and 5 grade-level scores (Flesch-Kincaid Grade Level, Gunning Fog Index, Coleman-Liau Index, Simple Measure of Gobbledygook Index, and Automated Readability Index), quality was evaluated using the DISCERN instrument, and errors of omission were evaluated using a standardized scoring system that was designed by the authors.

RESULTS

Flesch Reading Ease scores suggested that Wikipedia (mean 30.5; SD 8.4) was significantly easier to read (P=.03) than Schwartz (mean 20.2; SD 9.0). The mean grade level (calculated using all grade-level indices) of the Wikipedia articles (mean 14.2; SD 1.3) was significantly different (P=.02) than the mean grade level of Schwartz (mean 15.9; SD 1.4). The quality of the text was also assessed using the DISCERN instrument and suggested that Schwartz (mean 71.4; SD 3.1) had a significantly higher quality (P=.002) compared to that of Wikipedia (mean 52.9; SD 11.4). Finally, the Wikipedia error of omission rate (mean 12.5; SD 6.8) was higher than that of Schwartz (mean 21.3; SD 1.9) indicating that there were significantly fewer errors of omission in the surgical textbook (P=.008).

CONCLUSIONS

Online resources are increasingly easier to access but can vary in quality. Based on this comparison, the authors of this study recommend the use of vascular surgery textbooks as a primary source of learning material because the information within is more consistent in quality and has fewer errors of omission. Wikipedia can be a useful resource for quick reference, particularly because of its ease of reading, but its vascular surgery articles require further development.
Metabolite Fingerprinting Eleutherine palmifolia (L.) Merr. Using UPLC-QTOF-MS/MS
Authors: Mutiah Roihatul , Bhagawan Weka Sidha , Ma'arif Burhan , Rahmandika Jauhar Maknun Septaza
Published: February 2020

Eleutherine palmifolia (L.) Merr. (E. palmifolia) is an Indonesian native plant that has the potential to be developed into phytopharmaca. The differences in growth locations are thought to cause variation in the content of metabolite compounds which affect differences in pharmacological activity. This study aims to determine the profile of metabolites E. palmifolia bulb from several regions in Indonesia. The samples were collected from six different locations, namely East Java, Central Java, West Java, East Borneo, Central Borneo, and South Borneo. Sample extraction was carried out using Ultrasonic Assisted Extraction (UAE) method with 96% ethanol. The analysis of the content of metabolites was carried out using UPLC-QTOF-MS/MS with a stationary phase column C18 (Okta Decyl Silica), mobile phase mixture of formic acid /water 0.1/99.9 (v/v), and formic acid/acetonitrile 0,1/99,9 (v/v). The results of the analysis were interpreted using software Masslynx and continued with chemometric analysis using the method Principle Component Analysis (PCA). The results showed that there were differences in the content of the metabolite compounds in E. palmifolia bulb originating from six different regions.
A COMPARATIVE STUDY ON PHARMACOECONOMIC ANALYSIS OF RHEUMATOID ARTHRITIS PATIENT IN TWO DIFFERENT HOSPITALS IN TAMIL NADU
Authors: C. ARUL PRAKASAM K. , P. S. ATHMAJA KRISHNA , S. ALEENA , A. ASLAM , JOY MARIA
Published: February 2020

Objective: The objective of the present study is to compare the prescribing patterns and cost of illness of Rheumatoid arthritis patients in two different hospitals.

Methods: This is an observational study conducted in two different tertiary care hospitals in Salem district after obtaining approval of the Institutional Ethics Committee (IEC) (Registration Number EC/PHARM D/2019.06). A sample size of 102 (above 18 y) patients were included (52 from group 1 hospital and 50 from group 2 hospital). The study was conducted over a period of 6 mo from February 2019 to July 2019. The cost was collected by a patient face-to-face interview.

Results: Out of 102 patients, females (57.84%) patients were more prevalent than men with the age group of 50-59 y in both groups. Methotrexate was most commonly prescribed drug in group 1(36.5%), whereas in group 2 are Sulfasalazine (37%). Among the DMARDs unit cost of methotrexate is high but the monthly cost was high for Sulfasalazine, because the methotrexate is prescribed on a once-weekly basis while sulfasalazine is taken twice a day. The cost of NSAIDs comes around 46.47% of the total drug cost of the month. In steroids, cost comes around 11.73% of the total drug cost. Among the direct cost of two groups, the drug cost and transportation cost is higher when compared with other costs. Indirect costs such as lost wages, due to disease is higher in group 1.

Conclusion: The study concluded that the burden of RA to the patient is huge, Appropriate standard prescribing guidelines should be developed and implementation of the rational drug must be promoted. Polypharmacy was reported in group 1 hospital, the progression of symptoms was the same in both hospitals, it increases the cost of therapy and overall cost of patients. Hence it becomes vital to diagnose and control the disease at an early stage to control the economic burden on the patient.
2,4-SUBSTITUTED QUINAZOLINE AS JAK2 INHIBITOR: DOCKING AND MOLECULAR DYNAMICS STUDY
Authors: BUGGANA SIVA JYOTHI , PATURI MANI CHANDRIKA , VVS RAJENDRA PRASAD
Published: February 2020

Objective: The involvement of Janus kinase2/signal transducer and activator of transcription (JAK2/STAT3) pathway reported in various solid tumors made authors study the conformational changes of JAK2-3e complex which was previously reported with a moderate percentage of In-vitro JAK2 inhibition.

Methods: In this present study Compound 3e was reported with a moderate percentage of inhibition of JAK2 protein selected for performing molecular docking and molecular dynamics studies to elucidate the conformational changes with JAK2-3e complex. Docking studies were performed using ChemSketch to draw the structure of the compound and optimized/energy minimized using the Ligprep module of Schrodinger suite, employing optimized potentials for liquid simulations (OPLS-2005) force field. Molecular dynamics simulations were performed for 10 ns for complex using TIP4PEW water solvent model and neutralized by adding sodium ions.

Results: Docking studies of Compound 3e which has been reported as one of the effective cytotoxic agents and a moderate percentage of In-vitro JAK2 inhibition among the series, showed H-bond interaction with leucine 855, serine936, aspartine994. Dock score and Ligand binding energy with protein suggested compound 3e has shown-4.049,-66.003 kcal/mol respectively. Molecular dynamics simulations elucidated the mechanistic insight of JAK-2 inhibition. The Root means square deviation (RMSD) pattern of both protein and ligands in the JAK2-3e complex observed to be different over 10 ns simulation. In the JAK2-3e complex, an exponential increase in RMSD of Cα and side-chain amino acids is observed during the first 1-3 ns simulation and is stabilized till 10 ns. During the 10 ns simulation, ligand 3e seems to be stable in the complex with an overall deviation<1 Å, despite a drastic increase between 1-3 ns. The ligand RMSD plot suggests that the ligand 3e remained intact within the binding site of the protein and longer time period simulation may elucidate the binding pattern and fate of ligand 3e.

Conclusion: Results from molecular dynamics simulations elucidated the mechanistic insight of JAK-2 inhibition by 2, 4 disubstituted quinazoline compound that is N’(2-(4-nitrophenyl)quinazoline-4-yl) isonicotinohydrazide) and their binding phenomenon. Molecular docking studies further supported the elucidation of binding patterns of the molecules in the JAK-2 protein environment. Further simulations with a longer time period may provide deeper insights into ligand interactions in the protein environment. It is noteworthy to use compound 3e as a new scaffold for further development of multifunctional compounds.
ASSESSMENT OF MENSTRUAL HEALTH AND ANALGESICS USAGE IN YOUNG AGE WOMEN
Authors: AMEEN ALMOHAMMADI , SUHAIL JUNAID , LOUJAIN SHORBATLI , AMAL AL-SOMALI
Published: February 2020

Objective: The study focuses on assessing the incidence of menstrual irregularity among young women and the factors for a disturbance with the rationale to assess the use of analgesic drugs during Premenstrual Syndrome (PMS).

Methods: A cross-sectional study was used. A total of 2500 randomly selected young female between the age of 11 and 30 y completed the study questionnaire to assess lifestyle pattern, variations in menstrual pattern, perceived stress, and to capture information about their menstrual cycle and related problems. In addition, the questionnaire assessed the use of analgesics for PMS.

Results: 2481 participants completed the questionnaire. The mean age of participants’ menarche was 12.85±1.432 y. The prevalence of menstrual irregularities was 25.0 % (n=621) and about 8.5% (n=211) of respondents had severe pain that was not relieved by the use of analgesics. On the other hand, 50.9 % (n=1262) reported severe pain that was relieved by analgesics. A total of 1279 (51.6 %) of participants in this study used Over The Counter (OTC) analgesics to relieve PMS.

Conclusion: Dysmenorrhea is the most common complaint among young females in Saudi Arabia. Low Body Mass Index (BMI), sedentary lifestyle, stress and early age of menarche are the most important factors associated with menstrual irregularities. Proper education programs and awareness among young girls about their menstrual health, and the provision of guidance in choosing effective analgesics and treatment options for dysmenorrhea are highly recommended.
A Model to Choose Hub and Route Determination
Authors: Kevin Kevin , Aritonang Y. M. Kinley , Lesmono Julius Dharma
Published: February 2020

Determining a transport hub is a strategic decision to build a good distribution flow. In this paper, We suggested a model for choosing hub locations as sources for companies. In previous studies, The determination of hub locations with a vehicle routing problem is not integrated. Therefore, this study built a model to assess the position of the hubs by considering the budget. The business should have a decision on vehicle routing with hubs to reduce total transport costs. In addition, the method of distribution of goods for hubs and non-hubs with third-party logistics was determined by the use of a vehicle routing problem. The optimal weight was obtained through the analysis of sensitivity. In the sensitivity analysis, this study found that the best choice in this study was to use a weight of 0.9–1.0. It provides the lowest total cost of transport.
IGUALDADE ENTRE FILHOS ADOTIVOS E BIOLÓGICOS: DIÁLOGO ENTRE O DIREITO ROMANO E O DIREITO BRASILEIRO
EQUALITY BETWEEN ADOPTED AND BIOLOGICAL CHILDREN: A DIALOGUE BETWEEN ROMAN LAW AND BRAZILIAN LAW
Authors: Nascimento Letícia Queiroz Nascimento , Rocha Maria Vital da
Published: February 2020

O presente trabalho tem como objetivo dispor acerca da adoção na perspectiva do direiro romano e demonstrar como as normas romanas influenciaram este instituto no Brasil. A metodologia utilizada nesta pesquisa será eminentemente teórica, sendo empregados os métodos histórico e comparativo. Este estudo abordará aspectos fundamentais da família, status familiae e parentesco romano, bem como apresentará as modalidades de ingresso na família, nos termos estabelecidos pelo ordenamento jurídico romano, discorrendo acerca da Adoptio e Adoragtio. Posteriormente, haverá uma análise da adoção nos moldes fixados pelo direito brasileiro, principalmente no que tange ao princípio da igualdade estabelecido pela Constituição Federal Brasileira de 1988. Por fim, concluir-se-á que as normas sobre adoção vigentes no Brasil foram inspiradas pelo direito romano, contudo, evoluíram, estabelecendo a igualdade formal entre os filhos adotivos e biológicos.
KEMAMPUAN PEMAHAMAN KONSEP MAHASISWA DALAM MENGIDENTIFIKASI PENYELESAIAN SOAL INTEGRAL TAK TENTU DAN TENTU
Authors: Utari Rahma Siska , Utami Arini
Published: February 2020

Salah satu kemampuan dasar yang harus dimiliki mahasiswa sebelum menyelesaikan suatu permasalahan matematika adalah pemahaman konsep. Tujuan penelitian ini adalah mendeskripsikan kemampuan pemahaman konsep mahasiswa dalam mengidentifikasi penyelesaian soal-soal integral tak tentu dan integral tentu. Mengidentifikasi soal merupakan langkah awal yang harus dilakukan sebelum mengambil langkah selanjutnya untuk menyelesaikan soal tersebut. Penelitian ini adalah penelitian deskriptif kualitatif dengan subjek penelitian merupakan mahasiswa semester IV sebanyak 30 orang yang mengambil mata kuliah kalkulus integral. Tes dan wawancara adalah teknik pengumpulan data yang digunakan dalam penelitian ini. Selanjutnya data diolah dengan mereduksi data, menyajikan data dan penarikan kesimpulan atau menggunakan triangulasi. Hasil penelitian menunjukkan bahwa: 63,3% mahasiswa sudah memiliki kemampuan pemahaman konsep yang cukup baik. untuk mengidentifikasi penyelesaian jawaban dari kalkulus integral mahasiswa harus membaca dan memahami konsep dasar kalkulus and kemuadian mereka harus banyak latihan mengerjakan berbagai macam masalah kalkulus integral.
Religion and Politics in the Post-Soviet Russia (Example of Islam)
Authors: Pochta Yuriy M.
Published: February 2020

In the article, the author uses the example of Islam to examine the interconfessional relations, developing in the Russian Federation in the context of return of religion and religious beliefs to public life (revival of religion). This process affects both institutional aspects (evolution of the state’s federal structure, political system, formation of civil society) and value aspects of religion, such as its influence on the political culture of society, ideology of federalism and change in the content of secularism of the state. J. Habermas’ theory of deliberative democracy, the concepts of post-secular society and federalism, as well as the civilizational approach are used as the methodological base of the research. The author justifies his conclusion about the necessity to ensure respect for religious values while preserving the secular nature of the Russian state as an asymmetric Federation.
Institutional Foundations of Intraparty Coalitions in Presidential Systems: Case of Uruguay
Authors: Varshavsky Arseny Y.
Published: February 2020

The article analyzes the institutional foundations of the emergence and functioning of the major party factions in Uruguay and their influence on maintaining the stability of the presidential regime. The Uruguayan parties are historically characterized by fragmentation and consist of many ideologically diverse movements, which allows us to view them as coalitions. The factions competing among themselves for the influence on the political agenda ultimately form the party’s common strategy. Coalition tendency within parties is largely determined by the peculiarities of the electoral system established in Uruguay. The elected president with a broad mandate, being a representative of his faction, must build coalition relations with other factions of his party, giving them various concessions in the executive branch. Based on the factors considered, the author concludes that the electoral characteristics of the Uruguayan political system create the necessity for coalitions among party factions, thus affecting the stability of presidential rule.
Cooperation with Russia and the Current State of the RussianLanguage Community on the Agenda of the 2018 Election to the Seimas of Latvia
Authors: Krishtal Mihail I.
Published: February 2020

The article discusses the opinion of the relevant participants in the 2018 elections to the Seimas of Latvia in regards to the Latvian-Russian relations and the situation of the Russianspeaking community in the country. The issue sprung up in the period between the elections as a result of foreign policy (confrontation between Russia and the West to regards to the events in Ukraine) and internal political factors (adoption of the law stipulating the transfer of ethnic minority schools to teaching in the Latvian language). In the light of the ethnic conflict between Latvians and the Russian-speaking population in Latvia, the authors have based their research on S. Lipset and S. Rokkan’s theory of demarcations. Drawing on this theory, the authors use the scoring method to highlight ideological contrasts of political parties. As a result, three different approaches to the current situation have been identified. The first approach is focused on creating conditions for ethnic equality in Latvia and cooperation with Russia. The second approach, on the contrary, stands for limiting the rights of the Russian-speaking population in Latvia and continuing confrontation with the Russian Federation. The third approach, being ideologically close to the second, nevertheless allows for some latitude towards Russian-speaking residents. Based on Pearson’s correlation method, the analysis of the voting geography showed that the ideological contrasts existing between political forces coincide with their electoral divergences.
“Clash of Civilizations” Concept in the EU Right-Wing Populists’ Discourse
Authors: Byshok Stanislav O.
Published: February 2020

The concept of “clash of civilizations”, proposed by S. Huntington in the early 1990s, has been controversial, yet has found a solid following, primarily among the right side of the political spectrum in Europe and the US. Since such humanitarian aspects as culture, religion, civilization and national identity are central to modern political debates in the West, it is essential to delve more deeply into civilizational discourse of political actors. This article examines the idea of “clash of civilizations” in the rhetoric of three key right-wing populist parties of the EU: the French “National Rally” (“Rassemblement National”), the Hungarian “Fidesz” and the Dutch “Party for Freedom” (“Partij voor de Vrijheid”). While Huntington wrote about clashes of nations, representative of different civilizations, the right-wing populist focus on civilization clashes at national levels, primarily between Muslim immigrants coming to the EU, whose beliefs are pictured as intrinsically hostile to western values, and native-born Europeans who supposedly hold “JudeoChristian” civilizational identity. Judeo-Christian identity can de described as an “imaginary community” comprising some aspects of Christianity, Enlightenment & humanistic philosophy, which implies secularism and respect for human rights.
POTENSI KELELAWAR PEMAKAN BUAH (CHIROPTERA: PTERIPODIDAE) SEBAGAI RESERVOIR LEPTOSPIRA DI PROVINSI JAWA TENGAH
Authors: Ardanto Aryo , Muhidin Muhidin , Pratiwi Ayu Pradipta , Putro Dimas Bagus Wicaksono , Rahardianingtyas Esti , Raharjo Jarohman
Published: February 2020

Beside as seed dispersal and high valued plant pollinator, frugivorous bat (Pteripodidae) also has a role as reservoir of Leptospira. This study was aimed to survey the the prevalence of Leptospira among Pteripodidae in three regencies of Central Java Province namely Purworejo, Pati and Pekalongan, and their potential as reservoir of Leptospira. This study used four mist nets and a harp trap to collect bat at each site of each regency which has six sites. The caught bats were identified morphologically and followed by serological examination by Microscopic Aglutinasion Test (MAT). A total of 278 Pteripodidae was examined by MAT consisting of five genera with eight species. The result of MAT for Leptospira showed that there are no examined bats were positif (0%). It indicated there is no sufficient evidence that Pteripodidae as potential reservoir of Leptospira in Central Java.
INDEKS ENTOMOLOGI VEKTOR DEMAM BERDARAH DENGUE DI TIGA KABUPATEN DI PROVINSI BALI
Authors: Widjajanti Wening , Ayuningtyas Rima Tunjungsari Dyah , Adnyana Ni Wayan Dewi
Published: February 2020

Incidence rate Dengue Haemorrhagic Fever (DHF) in Bali Province ranks first in Indonesia in 2011-2015. DHF is caused by dengue virus transmitted by Aedes spp. The risk of DBD transmission is measured by density figure. This research was conducted in Jembrana, Karangasem and Badung Districts of Bali in 2017 with the aim to know the entomology’s index in those districts. Larvae of Aedes spp. collected from 100 homes in each location in the area. The results of mosquito larvae were calculated by indicator of larvae index of House Index (HI), Container Index (CI) and Breateu Index (BI). The result of HI in Jembrana, Karangasem and Badung’s districts are 19%, 27% and 45%. The result of CI in Jembrana, Karangasem and Badung’s districts are 9,25%; 17,37% and 24,41%. The result of BI in Jembrana, Karangasem and Badung’s districts are 25%, 41% dan 62%. The types of mosquito breeding places in Jembrana and Karangasem are mostly found in buckets, while in Badung regency were found in bathtube. The potential for DHF transmission is still ongoing in these three kabupates. The efforts of larvasidation, eradication of mosquito nests and extension should be done by these three districts.
PENINGKATAN PENGETAHUAN TENTANG SCHISTOSOMIASIS PADA GURU DAN MURID SEKOLAH DASAR DI KECAMATAN LORE BARAT KABUPATEN POSO
Authors: Koraag Meiske Elisabeth , Rosmini Rosmini , Nurwidayati Anis , Chadijah Sitti , Mujiyanto Mujiyanto , Veridiana Ni Nyoman , Tolistiawaty Intan
Published: February 2020

The provision of knowledge on schistosomiasis to the students and teachers of elementary schools increase their knowledge and affected the coverage of stool collection. Teachers and students are also expected to be able to provide information about the schistosomiasis which they have obtained to their families and communities around them. This research aimed to assess the success of the training of teachers and students in the control of schistosomiasis. This research was intervention research that used quasi-experiment design. The intervention was conducted by providing socialization about schistosmiasis to students and teachers in classrooms, followed by the practice in the field. The intervention and control group comprised 63 students and teachers. Evaluation of the teachers and students knowledge about schistosomiasis was conducted by questionnaire. The results of this research showed that in the intervention group, there was a significant increase in the knowledge from pre-test 9,25 to post-test 16,86 (p = 0.000). The provision of intervention in the form of knowledge to students and teacher has significantly increased the knowledge about epidemiology, treatment and surveillance schistosomiasis.
KELELAWAR MEGACHIROPETRA SEBAGAI RESERVOIR LYSSAVIRUS DI PROVINSI RIAU
Authors: Pratiwi Ayu Pradipta , Putro Dimas Bagus Wicaksono , Martiningsih Ika , Joharina Arum Sih , Indriyani Siska , Yacob Yulidar
Published: February 2020

Macroglossus sobrinus, Cynopterus brachyotis, dan Cynopterus sphinx terkonfirmasi sebagai reservoir Lyssavirus di Provinsi Riau. Penelitian dilakukan di tiga kabupaten, yaitu Kabupaten Kepulauan Meranti, Kota Dumai, dan Kabupaten Bengkalis. Lokasi pengambilan sampel dilakukan pada ekosistem hutan, non hutan, dan pantai.Penangkapan kelelawar dilakukan menggunakan mist net, harp net, dan hand net. Kelelawar terkoleksi diambil sampel swab trakea untuk pemeriksaan Lyssavirus. Deteksi Lyssavirus dilakukan meggunakan metode PCR. Dari 356 sampel yang diperoleh, 19 sampel terkonfirmasi positif Lyssavirus.
POTENSI TRIATOMA SP DALAM PENYEBARAN PENYAKIT TULAR VEKTOR EMERGING DI INDONESIA
Authors: Novita Risqa
Published: February 2020

The era of globalization allows migration fastly, so we do not have boundary of a country. This led to an increase of the infectious diseases. Indonesia also have an impact on this globalization by highly migration. Indonesia is a tropical country and has diversity of vectors that can transmit various tropical diseases. One of a vector  which transmitted vector borne diseases is a bug Triatoma. Triatoma lives near the people’s house and in the bed. One of the species of Triatoma which found in indonesia is Triatoma rubrifasciata which is vector of Chagas disease and Leprosy and can cause allergic reaction of the skin after the bite. Triatoma infection in Southeast Asia, including in Indonesia has not been widely reported. This condition should make us to be alert on the disease emerging or re emerging diseases that can be caused by Triatoma . This article aims to study Triatoma as a vector of emerging and potentially re emerging diseases in Indonesia, which are Chagas, skin allergic reaction after bite and Leprosy. Methods. Literature review by look in google scholar and pubmed, by search using keywords: emerging parasitic, vector borne diseases, Triatoma in Southeast Asia. Inclusion criterias are research articles, laboratory research, case report, and systematic surveillance. Based on the literatures, tracing data that Indonesia has a chance to be  the cases of Chagas disease, Skin allergic reaction of Triatoma and Leprosy. It is supposed to made the vigilance on  make a early warning system, so our public health coud be achieved highest.
Morphological changes and micronuclei frequency in microspore tetrads of Achillea millefolium from the areas of coal-fired power plants
Authors: Obidoska Grażyna , NADULSKA Agnieszka , NAGÓRSKA Edyta
Published: February 2020

W Polsce sektor energetyczny w 80% oparty jest na spalaniu węgla kamiennego i brunatnego, dlatego problemy związane z zanieczyszczeniem powietrza substancjami emitowanymi przy spalaniu tego typu paliw są dla nas bardzo istotne. Dwutlenek węgla i siarki, wielopierścieniowe węglowodory aromatyczne, dioksyny i furany oraz metale ciężkie, takie jak kadm i rtęć, mają negatywny wpływ na jakość powietrza, od której istotnie zależą zdrowie ludzi i stan ekosystemów. Celem badań była ocena wpływu dwóch opalanych węglem warszawskich elektrociepłowni na roślinność w ich sąsiedztwie. Gatunek Achillea millefolium został wybrany jako wskaźnikowy ze względu na znaczną stałość fitosocjologiczną na terenach obu elektrociepłowni oraz relatywnie dużą wartość c-DNA. Zaobserwowano zmiany morfologiczne i cytogenetyczne wskazujące na negatywne oddziaływanie elektrociepłowni na szatę roślinną na ich terenie oraz w bezpośrednim sąsiedztwie, potencjalnie prowadzące do sukcesywnej degradacji i niekorzystnych zmian w krajobrazie.
The influence of sacral buildings on spatial structure and landscape identity
Authors: Kaczyńska Małgorzata
Published: February 2020

Przedmiotem rozważań artykułu jest krajobraz kulturowy miasta oraz wpływ religii chrześcijańskiej (Kościoła rzymskokatolickiego) na ten krajobraz. Celem badań było określenie wpływu obiektów sakralnych na strukturę przestrzenną i tożsamość krajobrazu południowej Warszawy. Badania obejmowały analizę okresu, okoliczności powstania i zasięgu parafii oraz wyboru lokalizacji kościołów, określenie układu krajobrazowego i struktury przestrzennej parafii. Badania pokazały, że wpływ architektury sakralnej na strukturę przestrzenną i tożsamość krajobrazu jest nadal czytelny.