bluuebunny/crossref_metadata_2025 huggingface dataset:
FAKTOR–FAKTOR YANG MEMENGARUHI SIKAP PEMBELAJAR SEJATI MAHASISWA PROGRAM STUDI PENDIDIKAN AKUNTANSI
Authors: Palupi Yoanita Intan , Sudiyanto Sudiyanto , Susanti Asri Diah
Published: March 2024

Abstract The objective of this research is to examine factors that affect learners’ attitudes toward lifelong learning. A quantitative approach with a correlation design is used in this research. Stratified proportional random sampling was employed to determine its samples. They consisted of 194 students of Accounting Education from 2017-2021. Data Analysis used confirmatory factor analysis with structural equation modeling technique by means of the Lisrel 8.80 program. The results of the research show that (1) the family factor had a significant effect on the lifelong learner attitude of the students as indicated by t -statistic value of 2.60; (2) the school factor did not have a significant effect on the lifelong learner attitude of the students as specified by the t-statistic value of 0.59; (3) the social factor did not have a significant effect on the lifelong learner attitude as pointed out by the t-statistic value of 0.07; and (4) the individual factor had a significant effect on the lifelong learner attitude of the students an implied by the tstatistic value of 2.60. Next researchers are recommended to conduct further qualitative research to identify school and social factor indicators that are able to improve the lifelong learner attitude of students expecially in Indonesia.

 Abstrak Penelitian ini bertujuan untuk mengkaji faktor-faktor yang memengaruhi sikap mahasiswa terhadap pembelajaran sepanjang hayat. Pendekatan kuantitatif dengan desain korelasi digunakan dalam penelitian ini. Teknik sample yang digunakan adalah stratified proportional random sampling, dengan jumlah 194 mahasiswa dari angkatan 2017-2021. Analisis data yang digunakan adalah analisis faktor konfirmatori dengan teknik structural equation modeling menggunakan program Lisrel 8.80. Hasil penelitian menemukan bahwa (1) faktor keluarga berpengaruh signifikan terhadap sikap pembelajar sejati dengan nilai t-statistik 2.60; (2) faktor sekolah tidak berpengaruh signifikan terhadap sikap pembelajar sejati dengan nilai t-statistik 0.59; (3) faktor sosial tidak berpengaruh signifikan terhadap sikap pembelajar sejati dengan nilai t-statistik 0.07; dan (4) faktor individu berpengaruh signifikan terhadap sikap pembelajar sejati dengan nilai t-statistik 2.60. Peneliti selanjutnya direkomendasikan melakukan studi kualitatif lebih lanjut untuk mengidentifikasi indikator faktor sekolah dan sosial yang dapat meningkatkan sikap pembelajar sejati mahasiswa khususnya di Indonesia.

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Keywords : lifelong learner attitude, family factor, school factor, social factor, individual factor, SEM-LISREL
Kata Kunci : sikap lifelong learner, faktor keluarga, faktor sekolah, faktor sosial, faktor individu, SEM-LISREL
MENINGKATKAN LITERASI LINGKUNGAN ANAK USIA 5-6 TAHUN MELALUI PROJEK ECO ENZYME
Authors: Herawati Ida Ayu Made , Sindu Putra Ida Bagus Komang , Suyanta I Wayan
Published: March 2024

Anak usia dini lebih cepat belajar melalui pengalaman nyata. Fase ini memengaruhi pertumbuhan karakter, keterampilan motorik, kemampuan berpikir, bahasa, dan interaksi sosial anak. Kesadaran lingkungan juga ditanamkan pada anak untuk meningkatkan pemahaman tentang literasi lingkungan. Anak diajarkan melalui pembiasaan sederhana seperti membuang dan mengklasifikasikan sampah, dan mengolahnya menjadi eco enzyme. Projek eco enzyme menjadi inisiatif penting dalam menjaga lingkungan. Eco enzyme adalah cairan yang berguna sebagai pembersih alami, pupuk organik, dan pengendali hama, membantu mengurangi dampak negatif sampah pada lingkungan. Tujuan penelitian ini mencakup peningkatan literasi lingkungan anak, penerapan karakter cinta lingkungan melalui Projek Penguatan Profil Pelajar Pancasila (P5), serta pemahaman anak tentang proses pengolahan limbah organik menjadi eco enzyme. Penelitian ini menggunakan metode penelitian tindakan kelas (PTK) dalam dua siklus. Data dikumpulkan melalui observasi guru dan dokumentasi kegiatan anak. Hasilnya dianalisis dengan metode deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan peningkatan signifikan dalam literasi lingkungan anak dari siklus I (55%) menjadi siklus II (83%), dengan peningkatan sebesar 28%. Ini menunjukkan keberhasilan dalam meningkatkan pemahaman lingkungan pada anak usia 5-6 tahun melalui projek eco enzyme. Upaya memanfaatkan waktu luang siswa dan kreativitas guru dalam memanfaatkan alat dan bahan sekitar menjadi faktor keberhasilan dalam mengajarkan anak tentang pentingnya menjaga alam sekitar
STUDI KASUS FATHERLESS: PERAN AYAH DALAM PENGASUHAN ANAK USIA DINI
Authors: Nurjanah Novita Eka , Jalal Fasli , Supena Asep
Published: March 2024

Pentingnya peran ayah dalam pengasuhan anak bukanlah topik yang baru dalan penelitian di seluruh dunia termasuk di Indonesia. Kondisi yang ada di Indonesia, peran ayah dalam pengasuhan belum optimal hal ini dikarenakan masih adanya budaya patriarki bahwa peran pengasuhan menjadi tanggung jawab ibu; adanya pernikahan dini; dan adanya anak yang tidak tinggal bersama orang tua.  Hasil observasi awal ditemukan bahwa salah satu kecamatan di Boyolali menunjukkan bahwa tidak adanya kehadiran ayah atau fatherless dalam pengasuhan anak berdampak pada perkembangan anak usia dini. Di daerah ini masih menganut budaya patriarki yang kuat yaitu pengasuhan sepenuhnya merupakan peran ibu dan ayah berperan untuk mencari nafkah. Berdasarkan fenomena tersebut, penting dilakukan penelitian untuk mengkaji ketidakhadiran ayah atau fatherless dalam pengasuhan anak usia dini. Partisipan dalam penelitian ini adalah satu anak dari orang tua yang menikah dini di salah satu kecamatan Kota Boyolali. Anak ini berada dalam pengasuhan yang masih menganut budaya patriarki dan orang tua belum matang dalam memberikan pengasuhan kepada anak. Pendekatan strategi studi kasus tunggal digunakan untuk mendeskripsikan secara mendalam fatherless yang ada. Analisis tematik dari hasil wawancara mendalam terhadap orang tua digunakan dalam analisis data penelitian ini. Hasil penelitian menunjukkan bahwa ayah tidak memiliki peran dalam mengasuh anak, waktu bersama anak sangat minim, dan adanya paham budaya patriarki bahwa pengasuhan anak dilakukan sepenuhnya oleh ibu. Hal ini berdampak pada tidak adanya kelekatan antara anak dengan ayah, tidak optimalnya kemandirian anak, dan adanya gangguan kontrol perilaku anak.
PROFIL KEMAMPUAN MENGENAL BENTUK GEOMETRI ANAK USIA 5-6 TAHUN
Authors: Farida Annisa , Rasmani Upik , Hafidah Ruli
Published: March 2024

Kemampuan mengenal bentuk geometri anak usia dini merupakan penalaran matematis, yang terdiri dari pembentukan struktur hierarki konsep yang lebih tinggi untuk mengenali, menunjukkan, menyebutkan, dan mengumpulkan benda dengan menggunakan bentuk geometri. Penelitian ini bertujuan untuk mengetahui profil kemampuan mengenal bentuk geometri anak usia 5-6 tahun di TK Se-Kecamatan Banyudono Kabupaten Boyolali. Peneitian ini menggunakan metode deskriptif kuantitatif dengan jenis penelitian survei. Teknik pengambilan sample menggunakan random sampling. Teknik pengumpulan data menggunakan angket observasi penilaian dan wawancara diajukan untuk guru guna mengetahui kemampuan mengenal bentuk geometri. Teknik uji validitas instrumen menggunakan validitas konstruk dilakukan oleh Expert Judgment. Subjek penelitian meliputi anak usia 5-6 tahun sejumlah 226 anak di TK Se-Kecamatan Banyudono, Boyolali tahun ajaran 2019/2020. Hasil penelitian survei ini menampilkan bahwa kemampuan mengenal bentuk geometri berada dalam kategori baik. Sebanyak 7,08% (16 anak) kategori mulai berkembang, 50% (113 anak) kategori berkembang sesuai harapan, 42,92% (97 anak) kategori berkembang sangat baik. Uraian tersebut membuktikan hasil perkembangan kemampuan mengenal bentuk geometri di TK Kecamatan   Banyudono menunjukkan hasil capaian yang ideal untuk anak usia 5 sampai 6 tahun.Hasil inilah yang diharapkan menjadi informasi penting bagi guru dan peneliti selanjutnya guna memberikan inovasi pembelajaran serta memasukkan lebih banyak topik indikator berbeda untuk mengetahui perkembangan anak.
Pengaruh Penggunaan Media Bola Karet Terhadap Kemampuan Passing Atas Permainan Bola Voli Pada Siswa SMP Negeri 2 Karawang Barat
Authors: Saskia Saskia putri , Kurniawan Febi , Izzuddin Deden Akbar
Published: March 2024

Abstrak

          Permasalahan yang menjadi acuan dalam penelitian ini adalah Pengaruh Penggunaan Media Bola Karet Terhadap Kemampuan Passing Atas Permainan Bola Voli Pada Siswa SMP Negeri 2 Karawang Barat?. Berdasarkan permasalahan di atas maka, tujuan dalam penelitian ini yaitu untuk mengetahui Pengaruh Penggunaan Media Bola Karet Terhadap Kemampuan Passing Atas Permainan Bola Voli Pada Siswa SMP Negeri 2 Karawang Barat. Dalam penelitian ini diajukan hipotesis, yaitu Diduga adanya pengaruh yang signifikan Penggunaan Media Bola Karet Terhadap Kemampuan Passing Atas Permainan Bola Voli Pada Siswa SMP Negeri 2 Karawang Barat, Penelitian ini menggunakan metode ekperimen dengan pendekatan Kuantitatif. Adapun terdapat pengambilan sampel menggunakan teknik purposive sampling, dengan jumlah sampel sebanyak 32 orang siswa pada siswa SMP Negeri 2 Karawang Barat. Alat pengumpulan data yang digunakan yaitu: Tes Passing Atas. Dari perhitungan Hipotesis diperoleh t hitung (8,20) > t tabel (2,052) pada taraf nyata/signifikan = 0,05 dengan dk = 31 (2,052) Kriteria pengujian adalah, terima jika –t 1-½ < t hitung< t 1-½ . Dalam hal ini thitung berada pada daerah penolakan Ho, artinya Ho ditolak. karena H0 ditolak,  Maka kesimpulannya terdapat Pengaruh yang signifikan kemampuan passing atas bola voli Pada Siswa SMP Negeri 2 Karawang Barat sebelum dan setelah diberi penerapan Proses pembelajaran menggunakan bola karet.

Kata Kunci : Media, Bola Karet, Passing Atas, Bola Voli

Abstract

The problem that becomes a reference in this study is the influence of the use of rubber ball media on the passing ability of volleyball games in students of SMP Negeri 2 Karawang Barat?. Based on the problems above, the purpose of this study is to determine the effect of using rubber ball media on the passing ability of volleyball games in students of SMP Negeri 2 Karawang Barat. In this study, a hypothesis was proposed, namely that there was a significant influence of the use of rubber ball media on the passing ability of volleyball games in students of SMP Negeri 2 Karawang Barat. This study used an experimental method with a quantitative approach. As for there is sampling using the technique ofpurposive sampling, with a sample of 32 students to students of SMP Negeri 2 Karawang Barat.The data collection tools used are: Upper Passing Test. From the calculation of the hypothesis obtained t count (8.20) > t table (2.052) at the real/significant level = 0.05 with dk = 31 (2.052) The test criteria are, accept if –t 1-½ < t count< t 1-½ . In this case, tcount is in the area of ​​Ho's rejection, meaning that Ho is rejected. because H0 is rejected, then the conclusion is that there is a significant influence on the ability of passing over volleyball on students of SMP Negeri 2 Karawang Barat before and after being given the application of the learning process using rubber balls.

 Keywords : Media, Rubber Ball, Top Passing, Volleyball
Profile of the Refereeing Division of the Provincial Board of PBSI Gorontalo 2023
Authors: Dewi Ratna , Ardin Abdul Gani  , Iwan Fataha  , Samin Giofandi , Ramadan Gilang
Published: March 2024

ABSTRAK

Wasit merupakan faktor yang sangat menentukan jalannya pertandingan sesuai aturan, jadi memang seorang wasit bulutangkis harus mengetahui berbagai hal terkait aturan bulutangkis yang benar dan segala fasilitas yang mendukung pertandingan, sarana prasarana pertandingan sertahal-hal yang terkait ke pertandingan. Metode dalam penelitian ini adalah metode survey deskriptif kualitatif. Hasil dari penelitian ini adalah data seluruh wasit di PBSI Gorontalo. Kesimpulan dari penelitian ini adalah semua wasit yang ada di PBSI Provinsi Gorontalo memiliki pengalaman dalam memimpin banyak pertandingan dan semuanya memiliki lisensi baik kota maupun provinsi.

 

Kata Kunci: Wasit Bulu Tangkis

 

ABSTRACT

The referee is a very decisive factor for the course of the match according to the rules, so indeed a badminton referee must know various things related to the correct badminton rules and all the facilities that support the match, the match infrastructure as well as matters related to the match. The method in this research is a descriptive qualitative survey method. The results of this study are data on all referees in PBSI Gorontalo. The conclusion of this study is that all of the referees in the PBSI Gorontalo provincial management have experience in leading many matches and all of them have licenses for both the city and the province.

 

Keywords: Badminton Referee
Risk-based prioritization of Operational Condition Assessments : Trinity River and Willamette River case studies
Authors: Brown Willie , Richards John , Gallarno George , Morey Christopher , Rice Titus , Olszewski Jennifer
Published: March 2024

The US Army Corps of Engineers (USACE) operates, maintains, and man-ages over 700 dams and 4,000 miles of levees, providing approximately $257 billion worth of economic benefit to the Nation. USACE employs the Operational Condition Assessment (OCA) process to understand the condition of those assets and allocate resources to minimize risk associated with performance degradation. Understanding risk in flood risk management (FRM) assets requires an understanding of consequence of asset failure from a systemwide FRM watershed perspective and an understanding of likelihood of degradation based on the condition of the low-level components derived from OCA ratings. This research demonstrates a case-study application of a scalable methodology to model the likelihood of a dam performing as expected given the state of its gates and their components. The research team combines this likelihood of degradation with consequences generated by the application of designed simulation experiments with hydrological models to develop risk measures. These risk measures can be developed for all FRM gate assets in order to enable traceable, consistent resource allocation decisions. Two case study applications are provided.
Aplikasi Bot Telegram Pada Sistem Presensi dan Pengukuran Suhu Tubuh Berbasis IoT
Authors: Trishardian Rachmat , Fadli Ari , Aliim Muhammad Syaiful , Supriyanti Retno , Ramadhani Yogi
Published: March 2024

Coronavirus atau virus Covid-19 merupakan virus berbahaya dan sangat menular. Berdasarkan data dari worldometers.info per tanggal 30 Januari 2022 terdapat 375,001,247 kasus virus Covid-19 di seluruh dunia. Mengingat masih tingginya kasus virus Covid-19, maka diperlukan upaya untuk mencegah penyebaran virus Covid-19. Selain menerapkan perilaku hidup sehat, upaya pencegahan penyebaran virus Covid-19 juga dapat dilakukan dengan menciptakan inovasi teknologi. Salah satu inovasi teknologi tersebut adalah pemanfaatan bot Telegram pada sistem presensi dan pengukuran suhu tubuh berbasis internet of things (IoT) sebagai media pemantauan data, media pelaporan, dan media notifikasi. Bot Telegram ini berfungsi untuk menjalankan perintah dan memberikan pesan balasan sesuai dengan permintaan pengguna. Dalam penelitian ini, bot Telegram dibuat dengan menggunakan bahasa pemrograman PHP yang dikombinasikan dengan sebuah framework agnostic BotMan. Adapun metode pertukaran informasi pada bot Telegram dibangun dengan menggunakan metode webhook sehingga proses pertukaran informasi dapat dilakukan secara real time tanpa membutuhkan jeda waktu tertentu. Bot Telegram yang telah dibuat kemudian diuji dengan menggunakan black box testing berbasis equivalence partitions. Dari hasil pengujian, bot Telegram mampu menjalankan perintah pengguna sesuai dengan harapan sebanyak 20 dari 20 kali pengujian. Selain menguji kemampuan bot Telegram dalam menjalankan fungsinya, kemampuan bot Telegram dalam menanggapi perintah pengguna juga turut diuji. Dari 15 kali pengujian response time, bot telegram memiliki total rata – rata response time keseluruhan sebesar 0,9 detik yaitu termasuk ke dalam kategori cepat
Teaching Robots to Build Simulations of Themselves
Authors: Hu Yuhang , Lin Jiong , Lipson Hod
Published: March 2024

Simulation enables robots to plan and estimate the outcomes of prospective actions without the need to physically execute them. We introduce a self-supervised learning framework to enable robots to model and predict their morphology, kinematics and motor control using only brief raw video data, eliminating the need for extensive real-world data collection and kinematic priors. By observing their own movements, akin to humans watching their reflection in a mirror, robots learn an ability to simulate themselves and predict their spatial motion for various tasks. Our results demonstrate that this self-learned simulation not only enables accurate motion planning but also allows the robot to detect abnormalities and recover from damage.
Intelligent Transportation Storage Condition Assessment System For Fruits and Vegetables Supply Chain Using Internet of Things Enabled Sensor Network
Authors: Kumar Saureng , Sharma S C
Published: March 2024

Efficient transportation of fruits and vegetables is crucial for proper storage, handling, and distribution directly influencing their quality, shelf life, and ultimately the price. Maintaining optimal storage conditions during the transport of fruits and vegetables is of utmost importance to preserve their freshness and quality. Therefore, there is a pressing need for a real-time assessment system that can ensure the highest quality and safety of fruits and vegetables throughout the supply chain network. This paper introduces an Internet of Things (IoT)-enabled sensor network designed to address these challenges. The sensors are strategically deployed within the storage containers that continuously assessing real-time critical environmental parameters, such as temperature, humidity, pH, and air quality. These parameters significantly affect the storage of fruits and vegetables throughout the supply chain network. Furthermore, we have employed machine learning algorithms, such as decision trees, k-nearest neighbors, logistic regression, and Support Vector Machine, to measure performance in terms of accuracy, F1-score, precision, sensitivity, and specificity. The results indicate that the Support Vector Machine algorithm outperforms with the other algorithms with an impressive accuracy of 98.05%. Future research endeavors will focus on optimizing food supply chain loss.
Transforming Agricultural Living Labs Into Lighthouses Contributing to Sustainable Development as Defined by the UN-SDGs.
Authors: Bouma Johan , Reijneveld Arjan , (BSc). Mark Geling , (BSc) Edwin Geling
Published: March 2024

The UN Sustainable Development Goals (SDGs) were intended to be met by 2030 but recent reviews show that this will not be achieved and recommendations are made to Heads of State, Governments, the International Community and Member States to strengthen their efforts. Focusing on agriculture, we argue that a bottom-up effort is also needed in Living Labs, truly involving farmers that are now confused and rebellious about topdown rules and regulations. To provide clarity, we suggest: (i) selection of key SDGs by considering the proportionality principle, and: (ii) defining ecosystem services in terms of indicators and thresholds for income, production of healthy food, protection of water quality, contribution to energy preservation and climate mitigation and life on land, including soil health (SDGs 1,2,3,6,7,13,15). Indicators and thresholds have to be clear and measurable at reasonable cost. Introduction of innovative sensing techniques allowed rapid generation of relevant soil data in a field of a Living Lab being studied. When meeting all thresholds, a “Lighthouse” is established acting as an inspiring example for farmers with similar soils in a given region. Policies should focus on achieving thresholds of a set of indicators rather than on topdown prescribing certain management measures.
Lived Experiences and Coping Strategies among Cancer Patients in the Volta Region of Ghana: A Health Facility-Based Qualitative Study
Authors: Bonsra Emmanuel Abu , Morrison Leslie Kwesi , Anderson Haddiyat Offeibea , Ananga Mark Kwame , Amu Hubert
Published: March 2024

Background
Cancer is a global health challenge, impacting millions of lives annually. In Ghana, like many other countries, cancer remains a significant public health concern. This qualitative study explored the lived experiences of cancer patients, their coping strategies, and the availability of mental services for cancer patients.
Methods
This was a qualitative exploratory study which recruited 11 cancer patients and two health professionals from the Ho Teaching Hospital using in-depth interview guides. Data collected were analysed thematically using Atlas Ti 7.5.7.
Results
Regarding the lived experiences of cancer patients, the study unveiled profound emotional impact of receiving a cancer diagnosis, leading to a sense of devastation, fear, and even suicidal ideation among patients. Ongoing emotional challenges, including persistent depression, treatment-induced stress, and constant anxiety were prevalent throughout the cancer journey. Coping strategies adopted by patients included seeking support from loved ones, immersing themselves in work and avoidance-focused coping mechanisms, such as isolation and denial. We found that while specialized mental health support was mainly lacking for many cancer patients, the role of nurses in providing emotional support was crucial.
Conclusion
Living with cancer presents profound emotional challenges. Our study underscores the need for comprehensive mental health support services tailored to the unique needs of cancer patients. By addressing barriers which include stigma, limited availability of services, and a shortage of mental health professionals, the country would be making enormous progress towards Sustainable Development Goals (SDGs), particularly SDG 3 and 10 for ‘Good Health and Well-being’ and ‘Reduced Inequalities.’
Effects of cutaneous leishmaniasis on patients' quality of life
Authors: Yizengaw Endalew , Nibret Endalkachew
Published: March 2024

Introduction: Cutaneous Leishmaniasis (CL) is caused by protozoan parasite called Leishmania. It is endemic in more than 100 countries globally. Despite its vast prevalence and impact on quality of life, it is one of the most neglected tropical dermatological diseases. The CL burden has often been expressed based on the physical disfigurement caused by the disease. However, considering the impact of the disease beyond physical impairment and changes in patients’ appearance would help to better understand the disease as a public health problem. The effect of CL on patients' quality of life was determined in this study.
Methods: The data that were related to quality of life were collected using Standard one-week Dermatology Life Quality Index (DLQI) questionnaire. The questions were categorized under seven domains: symptoms & feelings, daily activities, work and school, leisure, personal relationships, and treatment. Each question was scored on a three-point scale: Very much (3), A lot (2), A little (1), Undecided (0), and Not at all (0). The sum of the scores lied between 0 to 48. A higher score shows worse quality of life. The data were entered and analysed using Statistical Package for Social Science 23. Frequencies and proportions were used to describe the data. Differences were considered statistically significant at p < 0.05.
Results: The lives of the majority of CL patients (60.7%) were significantly affected by CL. The quality of life of patients was moderately impacted by CL in 25% of the CL patients. In 32.1% of the CL patients, the effect of CL on patients' quality of life was very large. The quality of one CL patient's life was extremely largely affected. The disease had a small effect on 32.1% of the CL patients. The domain related with personal relationships was the most affected domain followed by symptoms and feelings, treatment, and leisure.
Conclusion: The Dermatology Life Quality Index demonstrates that CL has a small to extremely very large negative effect on the quality of life of patients.
Parallel chart writing and resilience impact the narrative competence of medical staff: a cross-sectional study in China
Authors: Xu Yun , Guo Hongkai , Ge Guomei , Shu Jing , Liu Li , Jin Qi , Jia Junjun
Published: March 2024

Narrative competence is essential for building a good communication relationship between medical staffs and patients. It is a powerful instrument for the delivery of holistic healthcare. However, there is little research focusing on the influencing factors of narrative competence and the relationships among resilience, self-efficacy, and narrative competence. The aim of the study is to explore the influence factors of narrative competence of medical staff and confirm the relationships among self-efficacy, resilience and narrative competence. A cross-sectional survey was conducted among 606 medical staffs from two affiliated hospitals, from Zhejiang and Heilongjiang province, respectively. The participants were scored by the Chinese narrative competence scale, the brief Chinese version of the resilience scale, and the Chinese version of self-efficacy scale. Results showed that the score of narrative competence was 149.76 ± 28.70, including the scores of listening dimension (48.01 ± 9.36), understanding dimension (67.75 ± 13.55), and reflecting dimension (34.00 ± 6.77). High narrative competence score was associated with hospital location and parallel chart writing (p<0.01). Pearson correlation analysis showed resilience and self-efficacy were positive related to narrative competence.
The influence of pyrazinamide resistant associated gene mutations on multidrug-resistant mycobacterium tuberculosis in China
Authors: Zhang Yuzhen , Li Yifan , Liu Yao , Kong Xianglong , Li Huaichen , Wang Tingting , Li Yameng , Zhu Xuehan , An Qiqi , Han Qilin , Fang Weiwei , Li Yingying , Long Fei , Tao Ningning
Published: March 2024

Background
Pyrazinamide (PZA) is essential for the treatment of drug-susceptible and drug-resistant tuberculosis (TB), especially multidrug-resistant (MDR) TB, but the condition of PZA resistance (PZA-R) across China is unknown. Our aim is to clarify the genetic mutations of PZA-R and the relationship between PZA-R and MDR-TB in China, from 2007 to 2019.
Methods
A total of 3202 TB strains with gene sequences results in China were included, among which 1447 strains were sequenced and 1775 were download from the European Nucleic Acid Sequence Database. Drug resistance was investigated by detecting resistance-conferring mutations. A phylogenetic tree was constructed to illustrate the genetic structure of the TB strains. Fisher's exact or Pearson's chi-square tests, as well as logistic regression analysis were used for correlation analysis. Those were calculated by SPSS software.
Results
All the 3202 strains were divided into four lineages (L1, L2, L3, L4), most belonged to L2 (2745, 85.7%), followed by L4 (443, 13.8%), the rest L1 plus L3 (14, 0.4%). About 45.6% (n = 1459) strains referred to isoniazid resistance (INH-R), 43.4% (n = 1389) rifampicin resistance (RIF-R), and 40.5% (n = 1296) MDR. There were 591 isolates resistant to PZA, among which 96.1% (n = 568) were also MDR. The rate of PZA-R was 43.8% (568/1296) among MDR isolates. The trends of PZA-R fluctuated in accordance with the trends of MDR, INH-R, RIF-R during 2007–2019. Up to 254 kinds of mutations associated with PZA-R were found, with 16.5% (n = 42) isolates harboring ≥ 2 PZA-R associated mutations. Codons 11 (encoding pncA_c.011A > G, n = 30, 11.8%), 76 (encoding pncA_p.Thr76Pro, n = 13, 5.1%), and 139 (encoding pncA_p.Val139Leu, n = 13, 5.1%) were the top three PZA-R associated mutation sites. All PZA-R mutation sites accounting at least 1% were included to analyse the influence of PZA-R on other drug resistance (MDR, INH-R, RIF-R). Finally, three PZA-R related mutations (pncA_p.Val139Ala, pncA_p.Thr47Ala, pncA_p.Leu85Pro) were associated with MDR, four were associate with (pncA_p.Thr76Pro, pncA_p.Val139Ala, pncA_p.Thr47Ala, pncA_p.Leu85Pro) INH-R and none was associated with RIF-R.
Conclusion
PZA-R especially gene mutation referred to pncA region may promote MDR, this phenomenon mainly associated with the function of PZA-R on INH-R. It is important to consider PZA-R particularly the three associated mutations (pncA region associated mutations) into consideration in treating MDR-TB and explore its mechanism.
Predicting anastomotic leak in patients with esophageal squamous cell cancer treated with neoadjuvant chemoradiotherapy using a nomogram based on CT radiomic and clinicopathologic factors
Authors: Zhao Junfeng , Yang Guanli , Li Ying , Li Shanshan , Luo Haining , Han Dan , Li Baosheng , Cao Qiang
Published: March 2024

Background
Anastomotic leak (AL) is a common complication in patients with operable esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoradiotherapy (NCRT) and radical esophagectomy. Therefore, this study aimed to establish and validate a nomogram to predict the occurrence of AL.
Methods
Between March 2016 and December 2022, 231 eligible patients with ESCC who underwent NCRT and radical esophagectomy were divided into training (n = 159) and validation cohorts (n = 72). Clinicopathologic and radiomics characteristics were included in the univariate logistic regression analysis, and statistically significant factors were enrolled to develop the nomogram, which was evaluated by the area under the curve (AUC) of the receiver operating characteristic curve, calibration curve, and decision curve analysis (DCA).
Results
Univariate and multivariate analyses revealed that dose at the anastomosis ≥ 24 Gy, gross tumor volume ≥ 60 cm3, postoperative albumin < 35 g/L, comorbidities, duration of surgery ≥ 270 mins, and computed tomography-based radiomics characteristics were independent predictors of AL. The nomogram AUC in the training and validation cohorts was 0.845 (95% confidence interval [CI]: 0.770–0.920) and 0.839 (95% CI: 0.718–0.960), respectively, indicating good discriminatory ability. The calibration curves showed good agreement between the predicted and actual AL occurrence and the DCA demonstrated favorable clinical outcomes.
Conclusions
We developed and validated a nomogram based on radiomics and clinicopathologic characteristics. This predictive model could be a powerful tool to predict AL occurrence in patients with ESCC treated with NCRT.
Molecular simulation study of adsorption-diffusion of CH4, CO2 and H2O in gas-fat coal
Authors: Jia Jinzhang , Xing Yinghuan , Li Bin , Wu Yumo , Wang Dongming
Published: March 2024

In order to clarify the microscopic dynamics mechanism of CH4, CO2 and H2O adsorption and diffusion in coal, and to reveal the mechanism of the influence of different temperatures and pressures on the adsorption and diffusion characteristics of coal adsorbed CH4, CO2 and H2O molecules. In this paper, the macromolecular structure model of Jixi gas-fat coal was constructed, based on the Giant Canonical Monte Carlo (GCMC) and Molecular Dynamics (MD) methods. The adsorption-diffusion characteristics of CH4,CO2 and H2O single-component gases in the gas-fat coal macromolecule model at temperatures ranging from 273.15K to 313.15K and pressures ranging from 0.01MPa to 15MPa were investigated by using Material Studio software. The research results indicated that: The adsorption of three gases, CH4, CO2 and H2O, increased with the increase of equilibrium pressure, and the adsorption isotherms conformed to Langmuir type I isotherms. The amount of saturated adsorption of CH4 ranged from 11.18 to 14.37ml/g, the saturated adsorption of CO2 ranged from 20.40 to 24.70ml/g, and the saturated adsorption of H2O ranged from 66.61 to 84.21ml/g. With the increase of temperature, the saturated adsorption of CH4 and CO2 both decreased, and the saturated adsorption of H2O firstly increased and then decreased, and the adsorption of H2O by low temperature and high temperature had both an inhibitory effect on the adsorption of H2O. The potential energy distributions of CH4, CO2 and H2O molecules are poisson distributed. The absolute values of the most available interaction energies are, from highest to lowest: H2O > CO2 > CH4; the activation energies for diffusion of CH4, CO2 and H2O are 12.20kJ/mol, 3.36kJ/mol, and 8.47kJ/mol, respectively, and the diffusion of CO2 is the more likely to occur. The adsorption of CH4 and CO2 in coal is physical adsorption, while the adsorption process of H2O molecules is beyond the scope of physical adsorption. The absolute value of the interaction energy is H2O > CO2 > CH4 in descending order.
The logic of coronavirus infection: revealing the heterogeneity of disease progression and treatment outcomes in COVID patients
Authors: Yu Guozhi , Huang Houhui
Published: March 2024

Pneumonia caused by coronavirus infection is a self-limiting disease. Its progression and prognosis are highly heterogeneous among people of different ages, genders, and living with different life styles. Such heterogeneity also exists in treatment outcomes of different patients. Various physiological and pathological factors, such as renewal of pulmonary cell, number of entry receptor and viral replication, have been identified linking to the development of the disease. However, it is still unclear how these factors collectively establish a causal relationship in the course of disease progression. In this study, we built a mechanistic model to explain the dynamics of infection and progression of coronavirus disease. We modeled how the interaction of pulmonary cells determine the dynamics of disease progression by characterizing the temporal dynamics of viral load, infected and health alveolar cells, and dysfuctional alveolar cells. The viral and cellular dynamics captured different stages of clinical manifestations in individual patient during disease progression: the incubation period, mild symptom period, and severe period. We further simulated clinical interference at different stages of disease progression. The results showed that some medical interventions show no improvement either in reducing the recovery rate nor shortening the recovery time. Our theoretical framework may provide a mechanistic explanation at the systems level for the progression and prognosis of coronavirus disease as well as other similar respiratory tract diseases.
Detecting Post-fire Burn Severity Level using Sentinel-2 and MODIS Satellite data
Authors: Shabbir Aqsa , Zia Sahar , Kazim Ali Hussain , Kasi Mumraiz , Jamshed Muhammad Ali , Waseem Liaqat Ali , Iqbal Naveed , Abbasi Qammer H , Ur-Rehman Masood
Published: March 2024

Background
Forest fires adversely affect forest ecosystem by altering its composition, structure, regeneration, and recovery potential of its landscape. The present study investigates forest fire hotspots and examines the relationship between these fire events and deforestation in Tehsil Dhansar, District Sherani, Balochistan. This study proposed a three-step research methodology to achieve its objectives. Firstly, it aims to assess the severity level of the forest burn resulting from the fire event. Secondly, it analyzes the extent of vegetation loss caused by the fire. Thirdly, the study identifies forest fire hotspots using Sentinel-2A images and MODIS Fire Radiative Power (FRP) data. The analysis involves utilizing Normalized Burn Ratio (NBR), Normalized Difference Vegetation Index (NDVI), and Hot Spot Analysis (Getis-Ord Gi*) to gain comprehensive insights into the pre- and post-fire situation accurately. By defining classes, the study achieves a better understanding of the extent of burnt areas and vegetation loss.
Results
The findings show that 0.03% of Tehsil Dhansar is found to have low to medium burn severity levels during any forest fire event. It is also revealed that the forest remained dominant in the same region and frequency of occurrence of forest fire events is increasing by 1.6% with each passing year.
Conclusion
The current study's findings in the region famous for the world's oldest forest have significant potential for similar landscapes worldwide, primarily characterized by dry deciduous forests and juniper forests well adapted to arid and semi-arid environments. Given these findings, further studies in the same location should prioritize obtaining precise in-situ measurements to deepen our understanding of the situation.
Gastric Cancer Tumor Immune Microenvironment Landscape: Clinical Implications for Patient Outcome and Response to PD-1 Immune Checkpoint Blockade
Authors: Shah Manish , Sarkar Sandipto , Melikhova Daria , Thakkar Prashant , Kudryashova Olga , Shin Nara , Love Anna , Samarina Naira , Postovalova Ekaterina , Tychinin Dmitry , Podsvirova Svetlana , Degryse Sandrine , Bagaev Alexander , Zavodovskaya Marianna , Elboudwarej Emon , Frenkel Felix , Yantiss Rhonda , Betel Doron , Fowler Nathan
Published: March 2024

Although gastric cancer (GC) may be classified into molecular subtypes based on the TCGA1 or ACRG2 classification, the tumor immune microenvironment (TME) remains under-evaluated in both systems. Using unsupervised clustering of gene expression signatures that describe the TME composition and properties of malignant cells from an integrated collection of 11 public cohorts, we identified five TME-based GC subtypes: mesenchymal (Mes), fibrotic (F), immune-enriched (IE), B-cell inflamed (BI), and immune-depleted (D). The GC TME subtypes provide important clinical annotation and are prognostic for patient survival. Mes and F GC were both stroma-enriched, although Mes GC also demonstrated WNT activation. Both stromal subtypes carry the worst survival, whereas alternatively, IE GC featured enhanced immune infiltration and is associated with the best prognosis. Although BI GC also demonstrated increased immune infiltration, it was associated with increased B cell signatures. The D subtype exhibited a cold immune TME with strong malignant cell properties, and with BI, these TME subtypes have intermediate survival. Microsatellite instable (MSI) GC that was IE exhibited significantly better survival than MSI GC that was not IE. The GC TME subtypes were also predictive of immune checkpoint blockade response. These newly defined GC TME molecular clusters provide a novel framework to inform clinical practice.
Laboratory Assessment of the Effect of Rice Husk, Groundnut Shells and Rha on the Shear, Permeability and Consolidation of Clayey Sands
Authors: K.L. Maithili , M.S. Nagakumar
Published: March 2024

Utilizing waste materials to improve soil properties can result in cost savings and environmental benefits. This study aims to determine the effect of adding agricultural wastes like rice husk ash (RHA), rice husk (RH), and groundnut shells (GS) to clayey sands from Mysore district, India. The study focused on the undrained strength, permeability and volume change behaviour of soils mixed with RHA, RH and GS. The soil samples were mixed with varying amounts of RHA (5%, 10%, 15%, and 20% by weight) and RH-GS (1%, 2%, 3%, 4%, and 5% by weight) and cured for 1, 7, 14 and 21 days. These blended specimens were then used to determine the maximum dry density (MDD), optimum moisture content (OMC) and unconfined compressive strength (UCS). The soil mixture containing 5% RHA and 4% (RH + GS) yielded optimal results in the UCS test. Further tests, including unconsolidated undrained (UU) triaxial, permeability and consolidation tests, were conducted on the parent soil and the soil composite with 5% RHA and 4%(RH + GS). From the undrained test, the strength increased for the soil admixture, with a reduction in the cohesion and an increment in the friction angle, compared to that of the parent soil. The experimental results also showed improvement in the permeability and consolidation characteristics of the blended soil.
Impact of the severe acute respiratory syndrome coronavirus 2 pandemic on the incidence of type 1 diabetes mellitus in children in Yamanashi, Japan
Authors: Saito Tomohiro , Mochizuki Mie , Kobayashi Kisho , Narusawa Hiromune , Watanabe Daisuke , Makino Koichi , Yagasaki Hideaki , Sato Kazumasa , Sano Tomoaki , Ohta Masanori , Yokomichi Hiroshi , Amemiya Shin , Kobayashi Koji
Published: March 2024

It is hypothesized that the biopsychosocial stress associated with the severe acute respiratory syndrome coronavirus 2 pandemic (SARS-CoV-2), in combination with the immunologic effects of SARS-CoV-2 and pancreatic β-cell dysfunction, may have contributed to the onset of type 1 diabetes (T1D) in children. We documented the incidence rates of T1D in Yamanashi Prefecture, Japan, from 1986 to 2018 and expanded our analysis to include cases from 2019 to 2022 to assess the influence of coronavirus disease 2019 (COVID-19) on the incidence of T1D. The annual increase in standardized incidences of T1D among 0- to 14-year-olds was 2.089% per year from 1986 to 2019 (p = .0772) and 2.183% per year from 1986 to 2022 (p = .0331). For the 5-9 year age group, the annual increase in crude incidence from 1986 to 2019 was 6.607% per year (p < .01), and from 1986 to 2022, it was 6.270% per year (p < .001). In Yamanashi Prefecture, Japan, the incidence of pediatric T1D increased during the COVID-19 pandemic from 2020 to 2022. However, this trend was an extension of the increase prior to 2019, suggesting that no direct or indirect effect of COVID-19 on this trend was identified.
Identification of RNA Modification-Related Differentially Expressed Genes in Acute Myocardial Infarction: Unraveling Diagnostic Perspectives and Immunological Microenvironment
Authors: Yan Zhisheng , Zhang Niancai , Sun Haixia , Cao Huihui , Ma Wanteng , Chang Qing
Published: March 2024

Acute myocardial infarction (AMI) is a critical cardiovascular disease with significant health implications. This study aims to investigate the role of RNA Modification-Related Genes (RMRGs), which are essential post-transcriptional regulators, in the pathology of AMI. By examining AMI-related datasets (GSE24519, GSE48060, GSE34198), RMRGs were collected from GeneCards and PubMed. The analysis involved enrichment analyses using Gene Expression Omnibus (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA). Additionally, Gene Set Variation Analysis (GSVA) was conducted, and regulatory networks (mRNA-miRNA, mRNA-TF, mRNA-RBP) were constructed. Immune cell infiltration was evaluated through single-sample gene-set enrichment analysis (ssGSEA) and CIBERSORT algorithms. In the AMI Dataset, 131 differentially expressed genes (DEGs) underwent GO and KEGG analyses, revealing significant enrichment in biological processes and pathways such as Allograft rejection, TNF signaling, and autoimmune diseases. GSEA identified gene enrichments in various pathways. Six key genes (APC2, C9ORF72, CDKN1C, GOLGA8A, PHKA2, RPL9) emerged as crucial factors in AMI development, as highlighted by Gene Set Variation Analysis (GSVA). Furthermore, extensive analysis was conducted on immune cell associations and interaction networks. The findings suggest that genes related to RNA modification, especially the identified key genes, significantly contribute to the pathogenesis of AMI. Consequently, this study provides valuable insights into the molecular mechanisms and potential treatments for AMI.
Identification of SCAF1 as a key factor affecting VEGF in LIHC and its potential target for therapy hypothesized based on network pharmacology and transcriptomics
Authors: Yu Zichuan , Zheng Hao , Tang Shengwei , Zhou Xuanrui , Zhou Minqin , Geng Xitong , Zhu Yanting , Huang Shuhan , Gong Yiyang , Jiang Yike , Chen Gen , Guo Liangyun
Published: March 2024

Introduction: Liver hepatocellular carcinoma (LIHC) is a highly vascularized entity closely associated with immune functions, characterized by high incidence, elusive early detection, high malignancy, and poor prognosis. SCAF1 participates in the immune regulation mechanisms of various cancers (gliomas, breast cancer, etc.) and is involved in regulating the level of gene transcription. Nevertheless, there is currently no research focusing on the multiple mechanisms of SCAF1 in LIHC, including angiogenesis promotion and immunomodulation.Materials and Methods: In this study, we obtained TCGA data and utilized Weighted Gene Co-expression Network Analysis (WGCNA) to explore hub genes, followed by evaluating the prognostic and clinical significance of SCAF1. Functional identification of SCAF1 in LIHC was performed through enrichment analysis. Subsequently, the immune therapeutic effects of SCAF1 were explored using TIMER and TISIDB. Spatial transcriptomics and single-cell sequencing analysis based on GEO data were conducted to assess heterogeneity tissue within the tumor microenvironment. Finally, molecular docking predictions were performed using Perl to evaluate pharmacological effects.Results: We identified a significant upregulation of SCAF1 in LIHC, and its overexpression may lead to decreased patient survival rates, enhanced levels of angiogenesis, invasion, and migration capabilities in LIHC. Chemokine analysis results demonstrated that the up-regulation of SCAF1 expression could inhibit the expression of cell factors such as CCL19. Experimental results demonstrated that genistein could downregulate SCAF1 and VEGFA in LIHC and inhibit cell invasion and migration levels.Conclusion: SCAF1 can influence angiogenesis in LIHC and affect tumor progression and therapeutic outcomes in LIHC patients through angiogenesis regulation.
Periviable preterm prelabor rupture of membranes: Outcomes of pregnancies following expectant management
Authors: Kuyucu Melda , Adiyaman Duygu , Atakul Bahar Konuralp , Golbası Hakan , Yorganci Özgün Uygur , Özeren Mehmet
Published: March 2024

Background: Periviable preterm rupture of membranes (PPROM) is associated with increased risk of perinatal morbidity and mortality. We aimed to assess the outcomes and predictive factors of ekspectant management in pregnancies with periviable preterm prelabor rupture of membranes (PPROM).
Methods: This was a retrospective study from January 2015 through December 2019. Women diagnosed with PPROM in the periviable period (20+0 to 25+6 weeks’ gestation) were included. Maternal demographics, clinical characteristics, and neonatal outcomes were reviewed. Clinical data were obtained from the medical records of a single center. Predictive factors for assessed using receiver-operator characteristic (ROC) curves.
Results: A total of 142 women with mid-trimester PPROM were evaluated. Among this, 119 (83.8 %) were managed expectantly and included in this study. Forty-five (37.8%) of these pregnancies benefited from expectant management; that is, the newborns survived to discharge from NICU. The remaining 74 pregnancies (62.2%) resulted in pre-viable births, stillbirths, deaths in the delivery room, and neonatal deaths. Pregnancies benefiting from expectant management had a longer latency period, had a greater birth weight, and were born at a more advanced GA compared to women who did not benefit from expectant management. Diagnostic cut-off values were obtained by Receiver-operator characteristic (ROC) curves for this indicators and their combination. ROC curve analysis identified GA at delivery ≤23 weeks, latency period ≤9 days, and birth weight ≤640 grams as predictors of unsuccessful expectant management.
Conclusions: Periviable PPROM is associated with poor neonatal outcomes with an overall survival rate of 37.8%. If the mother and fetus stabil during the expectant period, neonatal outcomes can be improved by increasing GA at birth, birth weight and latency period.