bluuebunny/crossref_metadata_2025 huggingface dataset:
Purine and pyrimidine metabolism regulatory gene signature predicts prognosis and immunotherapy efficiency in breast cancer
Authors: Chang Lidan , Cui Hanxiao , Ren Xueting , Dai Luyao , Zhai Zhen , Xiao Zhengtao , Wu Hao , Kang Huafeng , Ma Xiaobin
Published: July 2023

BACKGROUND Breast cancer (BC) is a heterogeneous disease with diverse molecular features and outcomes. Purine and pyrimidine (PP) metabolism provide sufficient nucleotides for tumor growth. Thus, the relationship between PP metabolism and BC needs a thorough exploration.METHODS Based on the 115 PP genes and BC multi-omics data, we performed consensus clustering and functional enrichment analyses to explore the biological characteristic. After the LASSO regression and multi-Cox regression analyses, a PP gene-related signature was developed. Moreover, data from the GSE45255, GSE21653, and GSE118389 cohorts, analyses included immunophenoscore (IPS) and single-cell RNA sequencing were employed to validate the predictability. Additionally, drug sensitivity and a comprehensive nomogram were explored for clinical practice.RESULTS PP genes were predominantly enriched in pathways related to immune stimulation, tumor aggressiveness, and EMT development. We identified three BC subtypes that possess different outcomes and immunological characteristics. We constructed an eleven-gene signature (SHCBP1, SSBP2, EIF4EBP1, FHL5, ACTL8, KLF9, IGKC, SEMA3B, CXCL1, CSTA, and IGLL5) that can be effectively for risk stratification, and was positively correlated with most T cell exhaustion-related genes (P < 0.05). The low-risk group possessed a better tumor microenvironment (P < 0.001), a higher expression level of immune checkpoint genes (P < 0.05), and showed immunotherapy benefits (P < 0.05). In addition, immune infiltrating cells demonstrated a characteristic distribution between the different risk groups (P < 0.05). Notably, patients with low-risk scores showed higher sensitivity to targeted drugs (veliparib, olaparib, and palbociclib), as well (P < 0.001).CONCLUSION PP metabolism regulatory gene signature suggests that patients assessed as low-risk have a better prognosis, immune microenvironment, and immunotherapy responses. It also inspired the exploration of biomarkers and provided novel strategies for clinical practice.
Indicators of suspended sediment transport dynamics in rivers
Authors: Shin Jae hun , Grabowski Robert C. , Holman Ian
Published: July 2023

Suspended sediment (SS) is a natural component of rivers, but elevated SS concentrations (SSCs) can impact aquatic ecosystems and engineering infrastructures. However, a significant gap remains in predicting SSC dynamics, which are influenced by catchment and climate factors that control sediment erosion, transport and deposition. The research aim is to develop and apply new SS transport dynamics indicators to determine how SSC varies spatially and temporally at a continental scale. Daily SSC data (mg/l) from 1,425 gauging stations in the US were used to calculate indicators of magnitude, frequency and timing (MFT). A filtering approach was applied to calculate frequency indicators that capture SSC events of differing durations. Spatial patterns in indicators were examined and integrated using K-means clustering. High SSC was identified at sites in dry and mountainous regions, but longer-duration SSC events were found in the northern US. The western coastal region and Puerto Rico had consistent timings of high SSC (winter and autumn, respectively). SSC magnitude had a decreasing trend over time across most of the US, but increasing trends were identified for the duration of SSC events. The use of MFT indicators is recommended for future studies to support prediction of climate change impacts on SSC.
HCST Expression Distinguishes Immune-hot and Immune-cold Subtypes in Pancreatic Ductal Adenocarcinoma
Authors: Ma Boyi , Zhang Dai-jun , Hu Yabin , Chen Xianghan , Gong Ruining , Lei Ke , Yu Qian , Ren He
Published: July 2023

Introduction:

Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent malignancy
of the pancreas, and the incidence of this disease is approximately equivalent to the mortality rate.
Immunotherapy has made a remarkable breakthrough in numerous cancers, while its efficacy in
PDAC remains limited due to the immunosuppressive microenvironment. Immunotherapy efficacy is
highly correlated with the abundance of immune cells, particularly cytotoxic T cells. Therefore, molecular
classifier is needed to identify relatively hot tumors that may benefit from immunotherapy.

Methods:

In this study, we carried out a transcriptome analysis of 145 pancreatic tumors to define the underlying
immune regulatory mechanism driving the PDAC immunosuppressive microenvironment. The
immune subtype was identified by consensus clustering, and the underlying PDAC immune activation
mechanism was thoroughly examined using single sample gene set enrichment analysis (ssGSEA). Area
under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to assess the accuracy
of the molecular classifier in differentiating immunological subgroups of PDAC.5

Results:

The protein level of molecular classifier was verified by immunohistochemistry in human
PDAC tissue. Immune-hot tumors displayed higher levels of immune cell infiltration and immune
checkpoint, in line with enriched immune escape pathways. Hematopoietic cell signal transducer
(HCST), a molecular classifier used to differentiate immunological subtypes of PDAC, has shown a
substantial link with the expression levels of cytotoxic markers, such as CD8A and CD8B. At the single
cell level, we found that HCST was predominantly expressed in CD8T cells. By immunohistochemistry
and survival analysis, we further demonstrated the prognostic value of HCST in PDAC.

Conclusion:

We identified HCST as a molecular classifier to distinguish PDAC immune subtypes,
which may be useful for early diagnosis and targeted therapy of PDAC.
Follicular Helper T Cells in Peyer's Patches and Galactose-
Deficient Iga1 Contribute to Iga Nephropathy
Authors: Huang Yuye , Sun Xunling , Nie Guoming , Xu Hongtao , Zou Minshu
Published: July 2023

Background:

Common primary glomerulonephritis with aberrant mucosal
immunity is IgA nephropathy (IgAN). T follicular helper (TFH) cells are essential in
regulating B cell differentiation. Peyer’s patches (PPs) are the main site where IgA+
plasmablasts differentiate.

Objective:

Our study aimed to investigate the TFH cell's potential contribution to the
etiology of IgA nephropathy.

Materials and Methods:

In PPs from IgAN mouse models, the ratio of the TFH cell, B220+IgA+,
B220+IgM+, and B220-IgA+ lymphocytes were assessed. Then, we used Western blot
to assess the expression of Bcl-6, Blimp- 1, and IL-21 proteins in PPs and used RTPCR
to assess the expression of IL-21 and TGF-β1 mRNA. TFH cells coculture with
spleen cells to measure the degree of IL-21 and the ratio of activation marker CD69 on
the TFH cells. Naive B cells (CD27-IgD+) from children suffering from IgAN were
cultured with TFH cell-related cytokines. The supernatant was detected to assess the
excretion of galactose-deficient IgA1 (Gd-IgA1).

Results:

IgAN mice developed noticeably increased degrees of IL-21 and CD69 on
TFH cells than controls did, as well as higher percentages of B220+IgA+, B220+IgM+,
B220+IgA+, TGF- β1, and IL-21 mRNA and Bcl-6, IL-21 proteins in PPs. The Gd-IgA1
level in the supernatant and IgAN- positive children's serum were noticeably higher than
those of the healthy controls (P < 0.05). PPs provide the microenvironment to induce
the production of IgA-secreting plasmablasts.

Conclusion:

TFH cells may be a key moderator to induce B cell differentiation into IgAsecreting
plasmablasts and produce Gd-IgA1, which plays a significant part in IgAN’s
pathogenesis. It could be a new therapeutic target in the future.
Antioxidant, Antibacterial, α-Amylase, and α-Glucosidase Inhibition, and
Anti-inflammatory Activities of Mimosa Rubicaulis Lam.
Authors: Adhikari Achyut , Shrestha Dipesh , Thapa Sushma , Pokhrel Tamlal , Sinjali Bishnu Bahadur , Baral Janaki
Published: July 2023

Background:

The use of medicinal plants as supplemental or alternative medicine is
widespread around the world. For the development of new drugs, studies on these medicinal plants
that include pharmacological and toxicological assessments are crucial.

Objective:

This work aimed to find the total phenolic and flavonoid content, antioxidant, antibacterial,
and antidiabetic potential of the traditionally used medicinal plant Mimosa rubicaulis Lam.

Methods:

The in vitro antidiabetic potential of methanolic extract and its fractions of the roots of
M. rubicaulis were performed via enzyme (α-glucosidase and α-amylase) inhibition assays. Antioxidant
and anti-inflammatory activities were carried out using 2,2 Diphenyl-1-picrylhydrazyl
(DPPH), and reactive oxygen species (ROS) inhibiting methods. Well diffusion method is applied
for antibacterial activity.

Results:

The crude extract reported the highest inhibition activity against α-glucosidase with an
IC50 value of 10.29 ± 0.35 μg/mL compared to the standard acarbose’s IC50 value of 5.653 ± 0.29
μg/mL. Similarly, the ethyl acetate (EA) fraction disclosed significant inhibition against α-amylase
with an IC50 value of 108.7 ± 0.66 μg/mL compared to the standard acarbose’s IC50 value of 6.01 ±
0.14 μg/mL. Likewise, the EA fraction showed the maximum antioxidant activity with an IC50 value
of 11.89 ± 1.05 μg/mL among the crude extract and its fractions.

Conclusion:

Mimosa rubicaulis was found to have α-glucosidase and α-amylase inhibition, antiinflammatory,
and antibacterial activity. To the best of our knowledge, this is the first report of α-
glucosidase and α-amylase inhibition activity of this plant. Further studies on this plant are required
to isolate potent compounds.
How Do Investors Respond to Targets’ Interim Earnings?
Authors: Gunn Rita , Pierce Spencer , Romney Miles
Published: July 2023

Fundamental to the accounting literature is that firms’ stock prices relate positively to their earnings news. We examine a setting where investors may be unsure to which firm the announced earnings accrue: earnings announced by acquisition targets between the announcement and completion of the acquisition. We find targets’ stock prices relate positively to their unexpected earnings during this interim period but only for unsuccessful M&A deals. For completed deals, we fail to find that targets’ or acquirers’ stock prices respond to targets’ unexpected interim earnings at the time of announcement. However, we find that targets’ interim earnings predict future returns of the combined firm following deal completion. A trading strategy based on targets’ interim earnings produces economically significant annualized abnormal returns of 7.25 percent. Our findings suggest investors respond inefficiently to the earnings that targets announce between the announcement and completion of acquisitions.

Data Availability: Data are available from the public sources cited in the text.

JEL Classifications: M40; M41; G34.
Bridging Energy Need and Feeding Behavior: The Impact of eIF2α Phosphorylation in AgRP Neurons
Authors: Kim Kwang Kon , Lee Tae Hwan , Park Byong Seo , Kang Dasol , Kim Dong Hee , Jeong Bora , Kim Jin Woo , Yang Hye Rim , Kim Han Rae , Jin Sungho , Back Sung Hoon , Park Jeong Woo , Kim Jae Geun , Lee Byung Ju
Published: July 2023

Eukaryotic translation initiation factor 2α (eIF2α) is a key mediator of the endoplasmic reticulum (ER) stress–induced unfolded protein response (UPR). In mammals, eIF2α is phosphorylated by overnutrition-induced ER stress and is related to the development of obesity. Here, we studied the function of phosphorylated eIF2α (p-eIF2α) in agouti-related peptide (AgRP) neurons using a mouse model (AgRPeIF2αA/A) with an AgRP neuron–specific substitution from Ser 51 to Ala in eIF2α, which impairs eIF2α phosphorylation in AgRP neurons. These AgRPeIF2αA/A mice had decreases in starvation-induced AgRP neuronal activity and food intake and an increased responsiveness to leptin. Intriguingly, impairment of eIF2α phosphorylation produced decreases in the starvation-induced expression of UPR and autophagy genes in AgRP neurons. Collectively, these findings suggest that eIF2α phosphorylation regulates AgRP neuronal activity by affecting intracellular responses such as the UPR and autophagy during starvation, thereby participating in the homeostatic control of whole-body energy metabolism.

Article Highlights

This study examines the impact of eukaryotic translation initiation factor 2α (eIF2α) phosphorylation, triggered by an energy deficit, on hypothalamic AgRP neurons and its subsequent influence on whole-body energy homeostasis. Impaired eIF2α phosphorylation diminishes the unfolded protein response and autophagy, both of which are crucial for energy deficit–induced activation of AgRP neurons. This study highlights the significance of eIF2α phosphorylation as a cellular marker indicating the availability of energy in AgRP neurons and as a molecular switch that regulates homeostatic feeding behavior.
IMPROVEMENT OF THE SYSTEM FOR MANAGEMENT OF ORGANIZATION'S COMMUNICATION WITH CONSUMERS BY AUTOMATING THE SERVICE PROVISION PROCESS IN THE CRM ENVIRONMENT
Authors: Khlystun D. M.
Published: July 2023

The project on the development of the concept of formalizing relations between service users and the state institution "Government Contact Center" is implemented. The developed concept is used for the development and integration of the CRM system module. Such research methods as basic statistical analysis, comparison, content analysis of secondary information, observation, and generalization have been used to solve the problematic tasks set in the research. It has been established that customer relationship management is a tool for achieving company loyalty through customer satisfaction with the level of services. Competent organization of the service automation process provides an opportunity to increase the efficiency of the employee and increase the client's loyalty to the actions of the institution or organization. It is found that, with the help of the concept of integrated marketing communications, the public can solve problems by contacting an institution or organization to resolve problematic issues. In order to carry out this activity, a working environment is needed through which communication between the institution and the client can be built. It is found that the CRM system provides an environment that would satisfy such requests. The software complex allows not only communication between the institution and the recipient of services but also systematization of all data. The main points regarding the value of using the CRM system in the work with users of the services of the state institution "Government Contact Center" are shown. The relationship between the knowledge base and the provision of services is shown. Based on the institution's CRM system, a mechanism for improving the knowledge base, which operates on the basis of the CRM system, is proposed, and it is shown how the institution's specialists can participate in its improvement. The stages of improving the knowledge base of the CRM system with the help of the new section "News Service of the Government Contact Center" and the role of the "Telegraph of News" section in it are described. The role and new responsibilities that arise as a result of the implementation of this concept for a group of employees are shown. It has been established that knowledge base consultants and experts play a decisive role in the launch of this concept of improving the knowledge base of the CRM system of the state institution "Government Contact Center".
Justice Expectations Related to the Use of CNNs to Identify CSAM. Technological Interview
Authors:   Faculty of Computer Science, Polish-Japanese Academy of Information Technology, Koszykowa 86, Poland, Warsaw 02-008, Oronowicz-Jaśkowiak Wojciech , Wasilewski Piotr ,   Intelligent Systems Laboratory, Systems Research Institute, Polish Academy of Sciences, Newelska 6, Poland, Warsaw 01-447, Kowaluk Mirosław ,   Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Banacha 2, Poland, Warsaw 02-008
Published: July 2023

A technological interview was conducted with representatives of the judiciary in order to determine their expectations and beliefs related to the technological solution (involving detection of child sexual abuse materials using CNNs), being developed. The obtained results lead to the following conclusions: 1. Representatives of the judiciary recognize the advantages of the technological solution being created in the form of accelerating the work of experts and minimizing the risk of mistakes. 2. Representatives of the judiciary see the limitations of the technological solution being created in the form of the inability to replace court experts and emphasize that it also depends on the stage of the case. 3.The selection of pornographic materials from a specific set for later verification by a forensic expert is of the greatest importance.
Detection of Dangerous Situations Near Pedestrian Crossings using In-Car Camera
Authors:   Czestochowa University of Technology, Dabrowskiego Street 69, 42-201, Czestochowa, Poland, Kubanek Mariusz , Karbowiak Lukasz ,   Czestochowa University of Technology, Dabrowskiego Street 69, 42-201, Czestochowa, Poland, Bobulski Janusz ,   Czestochowa University of Technology, Dabrowskiego Street 69, 42-201, Czestochowa, Poland
Published: July 2023

The paper presents a method for detecting dangerous situations near pedestrian crossings using an in-car camera system. The approach utilizes deep learning-based object detection to identify pedestrians and vehicles, analyzing their behavior to identify potential hazards. The system incorporates vehicle sensor data for enhanced accuracy. Evaluation results show high accuracy in detecting dangerous situations. The proposed system can potentially enhance pedestrian and driver safety in urban transportation.
Investigating the predictive role of vocabulary in written performance
Authors:   Universiti Teknologi MARA , Sabah Branch, Kota Kinabalu Campus, Wong Alice Su Chu , Lee Jocelyn Yee Vun ,   Universiti Teknologi MARA , Sabah Branch, Kota Kinabalu Campus
Published: July 2023

Existing research recognises the critical role of vocabulary in the acquisition of a second (L2) or foreign language. In the context of L2 writing, it has been established that as vocabulary size increases, so does the ability to write more effective texts. The purpose of this study was to investigate the relationship between vocabulary size and ESL students’ written performance.The participants were 69 Malaysian university students whose writing skills were assessed as part of their English course requirement. Vocabulary size was measured using Laufer and Nation (1990) Vocabulary Level Test (VLT). Performance on the VLT was correlated with writing scores as a measure of written performance. Findings indicated that a majority of participants achieved a mastery level of the 2000-word test but had difficulty in the 3000-word and 5000-word level. Participants’ vocabulary size was also found to be strongly associated with their written performance.These results elucidate the importance of vocabulary knowledge in L2 writing. The pedagogical implication of the current work calls for the integration of vocabulary in writing classrooms.
Couple-based interventions for secondary and tertiary prevention of intimate partner violence: A systematic review of randomized controlled trials
Authors: Emalia Faiqa Himma , Afiyanti Yati , Rachmawati Imami Nur
Published: July 2023

Background: Intimate partner violence (IPV) is the most tragic form of gender inequality and has devastating effects on women worldwide. A couple/family-based intervention approach has been developed and tested to address obstacles preventing intimate partner violence.
Purpose: This review aimed to examine couple-based interventions for secondary and tertiary intimate partner violence prevention.
Methods: The researcher searched the electronic databases ProQuest, Scopus, PubMed, Science Direct, SpringerLink, and Taylor & Francis for relevant articles. This review includes English/Indonesian research articles published between 2012 and 2022. This study reviewed various types of secondary and tertiary intimate partner violence prevention interventions and their effectiveness in reducing the incidence of intimate partner violence against women. Risk of bias assessment was performed used A Revised Cochrane Risk of Bias Tools for Randomized Controlled Trial (RoB 2).
Results: From the search findings, 1,819 articles were found, of which fifteen were included in the review, comprising twelve secondary preventive interventions and three tertiary prevention interventions make up these fifteen articles. Couple-based interventions for secondary prevention include gender transformative interventions, enhancing relationships with partners, bolstering the family economy, and encouraging men's participation in women's reproductive health and parenting. Cognitive-behavioral therapy predominates interventions for tertiary prevention to eliminate risk factors.
Conclusion: This article recommends using couple-based interventions under the population's inherent risk factors and pays close attention to the safety of the implementation process.
EFEKTIVITAS PELAKSANAAN PROGRAM BACA TULIS AL QUR’AN (BTQ ) TERHADAP PENINGKATAN KEMAHIRAN BACA TULIS AL-QUR’AN PADA MAHASISWA SEMESTER III JURUSAN PENDIDIKAN AGAMA ISLAM FAKULTAS TARBIYAH DAN KEGURUAN UIN ALAUDDIN MAKASSAR
Authors: Rusmin B Muhammad , Abu Bakar Abd. Syukur , Mosiba Risna
Published: July 2023

This journal discusses "The Effectiveness of the Implementation of the BTQ Program on Increasing Reading and Writing Proficiency in the Qur'an in Semester III Students Class of 2020 majoring in Islamic Religious Education, Faculty of Tarbiyah and Teacher Training UIN Alauddin Makassar". The problems discussed in this thesis are 1. How is the Implementation of the BTQ Program to Improve Reading and Writing Al-Qur'an Proficiency in Semester III Students Class of 2020 majoring in Islamic Religious Education 2. How is the Effectiveness of the BTQ Program to Increasing Al-Qur'an Reading Proficiency in Semester III Students Class of 2020 majoring in Islamic Religious Education.

This type of research is Quantitative where the data is in the form of numbers and uses statistical analysis. The population in this study were all Semester III students Batch 2020 majoring in Islamic Religious Education at the Tarbiyah and Teacher Training Faculty of UIN Alauddin Makassar, totaling 194 people. While the sample is 15% of the 30 students with the sampling technique using Random Sampling.

Based on the results of collecting and processing data using descriptive statistical analysis, the authors can conclude that the implementation of the BTQ Program in improving Al-Qur'an reading and writing skills in Semester III Students Class of 2020 majoring in Islamic Religious Education, Faculty of Tarbiyah and Teacher Training UIN Alauddin Makassar is considered very effective because in practice it is in accordance with the established rules as stated by the respondent.

The results of the analysis of inferential statistical testing, namely the t test, obtained the results of the hypothesis test that t_0 = 1.071 and t_table = 2.048. t_0<t_table (1.071 <2.048) then H_o is rejected H_I is accepted. Thus it can be concluded that there is a significant influence. The implementation of the BTQ program is very effective on the reading and writing ability of the Qur'an of students majoring in Islamic Religious Education, Faculty of Tarbiyah and Teacher Training, UIN Alauddin Makassar.

The implications for this research are that based on the results of the research, the authors think that it is necessary to maintain and support the implementation of the BTQ program at UIN Alauddin Makassar.
An avian Modified Glasgow Coma Scale as a prognostic indicator in raptors with head trauma
Authors: Foss Kari D. , Keller Krista A. , Reich Sarah K. , Franzen-Klein Dana , Scott David , Sosa-Higareda Mariana , Hague Devon W. , Whittington Julia , Allender Matthew C.
Published: July 2023

OBJECTIVE

To develop a Modified Glasgow Coma Scale (MGCS) for use in raptors presenting with head trauma and assess the agreement of the MGCS scores between examiners with varying backgrounds, and to assess the prognostic value of the avian MGCS in raptors with head trauma.

ANIMALS

156 native raptorial species.

METHODS

All raptors received an MGCS assessment within 8 hours of their presentation, between January 1, 2018, and December 31, 2019. For the first objective, the assessment was performed by a veterinary student, a wildlife veterinarian, and a board-certified or resident veterinary neurologist. Each animal received a score in 3 categories (motor activity, level of consciousness, and brain stem reflexes) and an overall score. For the second objective, the MGCS scoring was performed by the intaking clinical team member and survival after 48 hours was documented.

RESULTS

Agreement between the 3 individual scores was assessed via Cronbach α and intraclass correlation. There was excellent-good agreement in all 3 assessment categories as well as the overall score. Univariate associations between survival and demographic factors were determined using the χ2 test. Overall, raptors with a total MGCS of < 10 were less likely to survive than those with a score > 12.

CLINICAL RELEVANCE

An avian-specific MGCS demonstrated good-excellent agreement among raters of various backgrounds in assessing raptors with head trauma. Additionally, this study showed that an avian-specific MGCS may be correlated with the probability of survival within the first 48 hours after presentation to rehabilitation facilities in raptors with head trauma.
Implementación de un sistema de control y seguridad Informático ENDIAN FIREWALL
Authors: Zapata Escobar Daniel Eduardo , Gómez Tangarife Ignacio León , Acevedo Munera Jhon Darwin , Obando Ibarra Christian Hernán , García Arango David Alberto
Published: July 2023

La tecnología avanza aceleradamente siendo primordial éste mismo ritmo para la seguridad informática, adaptándose fácilmente a las necesidades de las empresas, incluso a las que no poseen sistemas de seguridad que ejecutan planes de mejoras. De lo anterior, es clave la implementación de un firewall que prevenga posibles ataques incrementando eficiencia y eficacia de todo el personal en sus labores diarias; permitiéndoles interactuar con el sistema de forma sencilla y segura. Reducir riesgos y vulnerabilidades en una empresa conlleva cambios importantes orientando los procesos internos y creando mecanismos de seguridad únicos centralizados estableciendo niveles óptimos de confianza, por ello en este artículo se presenta la forma en que se llevó a cabo el mejoramiento de control, protección de la navegación y la activación de características en la plataforma de Seguridad de una empresa, permitiendo generar medidas de defensa frente a HTTP/FTP, Filtro de Contenido web, Antimalware, VPN SSL, IDS. La herramienta de seguridad y control es un sistema único open source, específicamente estructurado y capaz de brindar soluciones óptimas a la red de datos, creando un vínculo estrecho entre los empleados y la seguridad informática, siendo responsabilidad de todos. Finalmente, se validaron los beneficios para la instalación del dispositivo de seguridad perimetral en donde confluyen diferentes servicios informáticos, estableciendo políticas de contenido para navegación interna de usuarios y personal externo, cumpliendo estándares de buenas prácticas, fortaleciendo la seguridad en su red, evitando la pérdida de información y el mal uso de las herramientas por parte de los usuarios.
FEATURES OF THE PHYSIQUE OF YOUNG SHEEP OF THE EDILBAEVSKY BREED OF DIFFERENT INTRA - BREED TYPES
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, TRAISOV B.B.
Published: July 2023

The article presents the results of measuring the main measurements of the body articles and the physique indices of young Edilbaev sheep of the Brlik, Suyundik and Kurmangazin intra-breed types. The analysis of the obtained results showed the advantage of young animals of all age groups obtained from rams of the Brlik type.
GENETIC ASSOCIATION OF GROWTH HORMONE (GH) GENE POLYMORPHISM WITH PRODUCTIVITY OF SOUTHERN MEAT BREED SHEEP
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, KULIKOVA A.YA.
Published: July 2023

In the results of the genotyping in the sub-populations of sheep of the southern region of the breed, the results of the analysis found a diff erent part of allele and genotypic gene in the locus of gormona rosta (extravasation), and IH associative of the evaluative with Rostom and development, formation of local productiveness and fertility. Heterozygous GH_ AB individuals exceeded homozygous GH_ AA by 2.4-3.95% in live weight, by 2.4% in wool shearing, by 12% in fertility.
THE INFLUENCE OF SEXUAL DIMORPHISM ON THE QUALITY OF THE WOOL OF GOATS OF THE TUVAN POPULATION
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, IRGIT R. SH.
Published: July 2023

The results of studying the eff ect of sexual dimorphism on the quality of down of goats of the Tuva population are presented. It has been shown, that the down of goats is coarser and longer than that of goats.
MORPHOLOGICAL STRUCTURE OF THE SKIN OF WOOLLY GOATS DEPENDING ON SEXUAL DIMORPHISM
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, KOSIMOV M.A.
Published: July 2023

The article presents some aspects of the regularity of the morphological structure of the skin with derivatives of the skin of goats of the Tajik wool breed and data on the thickness of the skin, its individual layers of diff erent sex and age groups.
MENINGKATKAN KEMAMPUAN BAHASA LISAN PADA ANAK USIA DINI MELALUI METODE SHOW AND TELL DI TK PERTIWI 01 CINGEBUL
Authors: Maftuhah Aeny , Ariyati Tatik
Published: July 2023

Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) yang terdiri dari dua siklus dengan setiap siklusnya terdiri dari tiga pertemuan. Penelitian ini dilatar belakangi dari kurangnya kreativitas dan inovasi guru dalam pengembangan kemampuan bahasa lisan anak di sekolah yang mengakibatkan kurang bervariasinya metode pembelajaran sehingga anak kurang tertarik pada pembelajaran bahasa khususnya bahasa lisan. Tujuan dari penelitian ini yaitu untuk mengetahui apakah metode show and tell dapat meningkatkan kemampuan bahasa lisan pada anak. Penelitian ini menggunakan jenis penelitian deskriptif dengan pendekatan kualitatif. Penelitian ini dilaksanakan di TK  Pertiwi 01 Cingebul. Hasil penelitian ini selain mengembangkan kemampuan bahasa anak juga dapat mengembangkan lima aspek perkembangan anak yaitu perkembangan kognitif, sosial-emosional, moral dan agama, fisik-motorik serta seni.
ЛАЗЕРНОЕ ИНИЦИИРОВАНИЕ ЭНЕРГОЕМКИХ МАТЕРИАЛОВ
Authors:   Федеральный исследовательский центр химической физики им. Н.Н. Семенова РАН, АССОВСКИЙ И.Г. ,   Национальный исследовательский ядерный университет «МИФИ», ДМИТРИЕНКО Д.Б. ,   Федеральный исследовательский центр химической физики им. Н.Н. Семенова РАН, КУЗНЕЦОВ Г.П. ,   Федеральный исследовательский центр химической физики им. Н.Н. Семенова РАН, МЕЛИК-ГАЙКАЗОВ Г.В. ,   Федеральный исследовательский центр химической физики им. Н.Н. Семенова РАН, СИНДИЦКИЙ В.П. ,   Российский химико-технологический университет имени Д. И. Менделеева
Published: July 2023

Целью работы является краткий обзор теоретических и экспериментальных исследований механизма лазерного инициирования (ЛИ) энергоемких материалов (ЭМ), выполненных за последние годы в лаборатории физики горения твердых топлив ФИЦ ХФ РАН. Теоретический анализ проводится в рамках нерезонансного (теплового) воздействия светового излучения на ЭМ. Определенное внимание уделяется особенностям инициирования металлизированных взрывчатых веществ (ВВ) коротким лазерным импульсом малой энергии. Анализируются физические и химические факторы в процессе ЛИ, в том числе влияние формы и размера металлических включений. Рассматривается влияние диаметра светового луча, а также размера и природы оптических неоднородностей. Демонстрируются особенности влияния перечисленных факторов в зависимости от длительности лазерного импульса и плотности светового потока. Впервые демонстрируется возможность прямого ЛИ детонации открытого вторичного взрывчатого материала.
Synergistic Effect of Potassium Iodide on Inhibitive Performance of Propyl Alcohol during Corrosion of Mild Steel in 1.0M HCl
Authors: Yaro Aprael. S. , Abdul Majeed Basma A. , Atiyah Elaf Q.
Published: July 2023

The inhibition of mild steel corrosion in 1.0M HCl by 1-propanol and the synergistic effect of potassium iodide (KI) was investigated using weight loss and polarization techniques in the temperature range (30 ‒ 50) ̊ C. A matrix of Doelhert to three factors was used as the experimental design, adopting weight loss results as it permits the use of the response surface methodology which exploited in determination of the synergistic effect as inhibition on the mild steel. The results were confirmed using electrochemical polarization measurements. Experimental results showed that the inhibition efficiency (IE%) increases with increase in concentration of inhibitor and with increasing of temperature. The addition iodide ions to alcohol (inhibitor) enhanced the inhibition eﬃciency due to synergistic eﬀect. Potentiodynamic polarization studies showed that the studied compound is mixed-type inhibitor causing blocking of active sites on the mild steel surface .The adsorption of  the inhibitor and its combination with iodide ions on mild steel surface followed    

   Langmuir adsorption isotherm via physisorption mechanism, which was proposed based on values of adsorption Gibbs free energy difference ΔGads. Statistically, the multi-variable regression equation describes the behavior of the corrosion inhibition process with high accuracy (correlation coefficient R2 between 0.974 and 1).
Adsorption of Fluoroquinolones Antibiotics on Activated Carbon by K2CO3 with Microwave Assisted Activation
Authors: Abbas Ammar S. , Ahmed Muthana J. , Darweesh Teeba M.
Published: July 2023

The preparation of low cost activated carbon from date stones and microwave method by using K2CO3 as chemical activator were investigated.

   The prepared activated carbon was used to remove fluoroquinolones antibiotics from aqueous solution. The characterizations of the activated carbon is represented by surface area, pore volume, ash content, moisture content, bulk density, and iodine number. The adsorbed fluoroquinolones antibiotics are Ciprofloxcin (CIP), Norfloxcin (NOR) and Levofloxcin (LEVO). Different variables as pH, initial concentrations and contact time were studied to show the efficieny of prepared activated carbon. The experimental adsorption data were analyzed by Lungmuir, Freundlich, and Temkin isotherm. The experimental results are described by Lungmiur isotherm. The kinetic data were fitted to pseudo-first order kinetics, pseudo-second order kinetics and interparticle diffusion model. The kinetic adsorption data were best fitted by psuedo-second order kinetic.
YATAYA YAKIN KALIN KÖMÜR DAMARLARINDA DAMAR EĞİMİNİN UZUNAYAK YÖNTEM VERİMLİLİĞİNE ETKİSİNİN FİZİKSEL MODEL İLE ARAŞTIRILMASI
Authors: ÇELİK Arif
Published: July 2023

Göçertmeli uzunayak yöntemi geleneksel yönteme ek olarak tavan kömürü göçertme işleminin yapıldığı etkili bir yeraltı üretim yöntemidir. Yöntem kömür damarının eğiminde ya da yatay kalınlığında ayak oluşturulmak suretiyle iki farklı şekilde uygulanabilmektedir. Bu çalışmada damarın eğiminde ayak oluşturularak uygulanan göçertmeli uzunayak yöntemi araştırılmıştır. Yapılan araştırmada, yataya yakın kalın kömür damarlarında uygulanan göçertmeli uzunayak yönteminde damar eğiminin yöntem verimliliğine etkisi çalışma kapsamında geliştirilen 2 boyutlu fiziksel bir model ile incelenmiştir. Fiziksel model çalışmaları sonucunda, çekilen tavan kömürü miktarı ile damar eğimi arasında doğrusal bir ilişki tespit edilmiştir. Buna karşın kaya karışım oranının damar eğimindeki artışa bağlı olarak belirli bir noktaya kadar arttığı sonrasında ise azalmaya başladığı belirlenmiştir. Ayrıca tavan kömürü akma sınırlarının da damar eğimindeki artışa bağlı olarak ayak ilerleme yönüne doğru yöneldiği gözlemlenmiştir.
Shortlists of workplace support for autistic employees: A freelisting study in the UK
Authors: Petty Stephanie , Eccles Niamh , Tunstall Lid , Richardson Hannah
Published: July 2023

BACKGROUND: Employment prospects are poor for autistic adults, despite their abilities and desire to work. OBJECTIVE: In this study, autistic and non-autistic employees gave shortlists of positive contributions of autistic employees, workplace difficulties and any adjustments being made to support autistic employees in the United Kingdom (UK). This aimed to provide routine and achievable good practice examples. METHOD: An online questionnaire was completed by 98 employees, mostly from the education sector. Freelisting methodology was implemented, which is a qualitative interviewing and data analysis technique whereby participants give their answers to survey questions as lists, to identify priority answers for a particular group. RESULTS: Consensus analysis showed that workplaces agreed on ways that autistic employees contribute positively to the workplace, including approaching workplace tasks from a different angle, attention to detail and contributing innovative and creative thinking. The main difficulties for autistic employees were noise and communication differences relative to non-autistic peers. Despite agreed difficulties and positive contributions, autistic and non-autistic employees reported usual practice in their workplaces as there being no reasonable adjustments made. CONCLUSION: Findings show the need for investment into inclusive and supportive workplaces, and call for further research into good employment practices as identified by autistic employees.
Evaluation of the epidemiological profile and mortality of elderly with femur fracture residents in the state of Sergipe between january 2011 and december 2020
Authors: Oliveira Douglas Santos , Amaral Ricardo Guimarães , Andrade Luciana Nalone
Published: July 2023

Introduction Femur fracture in the elderly is a disease with significant morbidity and mortality and high incidence in Brazilian society. The main trauma mechanism is the accidental fall from own height and osteoporosis is the most important risk factor. Objective Define an epidemiological profile of elderly with femur fractures in the state of Sergipe. Methodology Descriptive, cross-sectional, quantitative study, based on the hospital admission system with data available on the DATASUS platform in the period between Jan/2011 and Dec/2020. Results An average annual incidence of 182/100,000 elderly was observed, this data showed an important growth with increasing age; regarding gender, there was a greater number of cases in females, with 2.17 more cases compared to males. There were 302 deaths in the period, with an average mortality rate of 7%. The average annual expenses corresponded of 885 thousand reais and average hospitalization time was about 12 days. Conclusion Femur fractures are quite common in the elderly population, with greater involvement in females, with a tendency to increase the number of cases over the years. A very high mortality rate was observed in the state, an alarming fact that highlights the need for more studies and improvement of public policies in the area to improve management and reduce morbidity and mortality.
Uso da toxina botulínica como tratamento coadjuvante na disfunção temporomandibular e dor orofacial
Authors: Coelho Ana Carla Leite Alberto , Monteiro Angélica Brito , Peres Larissa Silva , Bittencourt Pedro Augusto Peixoto , Caetano Roberta Mansur , Pereira Wesley Luis Rodrigues
Published: July 2023

O objetivo desse estudo foi avaliar o uso e a eficácia da toxina botulínica para o declínio da sintomatologia que essa disfunção causa, por meio de relato de caso de uma paciente que apresenta DTM no qual foram realizadas duas aplicações da toxina botulínica tipo A por um cirurgião-dentista capacitado, exames clínicos baseados nos Critérios de Diagnóstico de Pesquisa para Disfunções Temporomandibulares (RDC/TMD) anteriormente à aplicação e um acompanhamento de 45 dias após a primeira aplicação para verificar o resultado. Verificou-se que a ação da Toxina Botulínica Tipo A (TXB-A) sobre os músculos masseter e temporal diminuiu significativamente a sintomatologia da paciente logo na primeira aplicação. Na segunda, somente o músculo masseter recebeu a toxina por ainda apresentar dores. Com o acompanhamento utilizando o RDC/TMD foi possível verificar a decadência da sintomatologia muscular, permanecendo apenas a Disfunção Temporomandibular (DTM) articular. Concluiu-se que a toxina botulínica tipo A não deve ser o tratamento de eleição devido às controvérsias de seu uso como terapia, mas sim como tratamento coadjuvante para a sintomatologia muscular da DTM, sendo necessário ainda maiores estudos para avaliar o resultado a longo prazo.
KMT2C knockout generates ASD-like behaviors in mice
Authors: Brauer Bastian , Merino-Veliz Nicolas , Ahumada-Marchant Constanza , Arriagada Gloria , Bustos Fernando J.
Published: July 2023

Neurodevelopmental disorders have been associated with genetic mutations that affect cellular function, including chromatin regulation and epigenetic modifications. Recent studies in humans have identified mutations in KMT2C, an enzyme responsible for modifying histone tails and depositing H3K4me1 and H3K4me3, as being associated with Kleefstra syndrome 2 and autism spectrum disorder (ASD). However, the precise role of KMT2C mutations in brain disorders remains poorly understood. Here we employed CRISPR/Cas9 gene editing to analyze the effects of KMT2C brain specific knockout on animal behavior. Knocking out KMT2C expression in cortical neurons and the mouse brain resulted in decreased KMT2C levels. Importantly, KMT2C brain specific knockout animals exhibited repetitive behaviors, social deficits, and intellectual disability resembling ASD. Our findings shed light on the involvement of KMT2C in neurodevelopmental processes and establish a valuable model for elucidating the cellular and molecular mechanisms underlying KMT2C mutations and their relationship to Kleefstra syndrome 2 and ASD.
Revealing the role of renewable energy consumption and digitalization in energy-related greenhouse gas emissions—Evidence from the G7
Authors: Chen Yuze , Chen Ying , Zhang Liuyue , Li Zhi
Published: July 2023

The massive consumption of energy promotes rapid economic growth, but it also unavoidably results in a large amount of greenhouse gas emissions, which seriously hinders society’s green and low-carbon development. This paper aims to explore the real impact of renewable energy and digitalization on greenhouse gas emissions from an energy-related perspective using advanced panel econometrics methods based on G7 panel data for 1990–2020. Economic growth and energy efficiency are also considered as control variables. Due to the nonlinear properties of panel data, the moment quantile regression approach is utilized in this research. The findings show that slope heterogeneity is widespread, section-dependent, and has a long-term equilibrium relationship. In addition, digitalization, renewable energy, and energy efficiency can reduce energy-related greenhouse gas emissions and ease environmental pressures. Economic expansion, on the other hand, remains an important positive driver for energy-related greenhouse gas emissions. The results of this study are robust and the causal relationships between variables are tested. Based on the conclusion presented above, this study advises the G7 economies to expand investments in renewable energy and digitalization to promote energy system transformation and pave the road for global decarbonization objectives to be met.
Development of a novel immune infiltration-related diagnostic model for Alzheimer’s disease using bioinformatic strategies
Authors: Zhuang Xianbo , Zhang Guifeng , Bao Mengxin , Jiang Guisheng , Wang Huiting , Li Shanshan , Wang Zheng , Sun Xiujuan
Published: July 2023

Background

The pathogenesis of Alzheimer’s disease (AD) is complex and multi-factorial. Increasing evidence has shown the important role of immune infiltration in AD. Thus the current study was designed to identify immune infiltration-related genes and to explore their diagnostic value in AD.

Methods

The expression data of AD patients were downloaded from the GEO database. The limma R package identified differentially expressed genes (DEGs) between AD and controls. The CIBERSORT algorithm identified differentially infiltrated immune cells (DIICs) between AD and controls. DIIC-correlated DEGs were obtained by Pearson correlation analysis. WGCNA was employed to identify DIIC-related modules. Next, LASSO, RFE, and RF machine learning methods were applied to screen robust DIIC-related gene signatures in AD, followed by the construction and validation of a diagnostic nomogram. Detection of the expression of related genes in the peripheral blood of Alzheimer’s disease and healthy volunteers by RT-PCR. In addition, the CTD database predicted chemicals targeting DIIC-related gene signatures in the treatment of AD.

Results

NK cells, M0 macrophages, activated myeloid dendritic cells, resting mast cells, CD8+ T cells, resting memory CD4+ T cells, gamma delta T cells, and M2 macrophages were differentially infiltrated between AD and controls. Pearson analysis identified a total of 277 DIIC-correlated DEGs between AD and controls. Thereafter, 177 DIIC-related genes were further obtained by WGCNA analysis. By LASSO, RFE and RF algorithms, CMTM2, DDIT4, LDHB, NDUFA1, NDUFB2, NDUFS5, RPL17, RPL21, RPL26 and NDUFAF2 were identified as robust gene signature in AD. The results of RT-PCR detection of peripheral blood samples from Alzheimer’s disease and healthy volunteers showed that the expression trend of ten genes screened was consistent with the detection results; among them, the expression levels of CMTM2, DDIT4, LDHB, NDUFS5, and RPL21 are significantly different among groups. Thus, a diagnostic nomogram based on a DIIC-related signature was constructed and validated. Moreover, candidate chemicals targeting those biomarkers in the treatment of AD, such as 4-hydroxy-2-nonenal, rosiglitazone, and resveratrol, were identified in the CTD database.

Conclusion

For the first time, we identified 10 immune infiltration-related biomarkers in AD, which may be helpful for the diagnosis of AD and provide guidance in the treatment of AD.