bluuebunny/crossref_metadata_2025 huggingface dataset:
Outcome of adults with diabetic ketoacidosis admitted to intensive care unit: a retrospective study.
Authors: Alhamdan Qais , Bahobeshi Abdulrahman , Alharbi Atheer , Alsayafi Zahrah , Aljedani Haneen , Alziyadi Mohammed , Alqarni Mohammed , Al-Hamayel Reham , Almuyidi Shatha , Alomar Abdulaziz , Alharbi Osama , Gusti Amira
Published: December 2023

Background: Numerous advancements in diabetes care have been made over the past 20 years. Few studies discussed the outcome and predictors of diabetic ketoacidosis (DKA) necessitating admission to intensive care units (ICU). We, therefore, performed a retrospective analysis of DKA patients admitted to King Saud Medical City\'s ICU between August 2022 and August 2023 to examine trends in outcome and predictors.
Method: Patients with DKA episodes who visited the emergency room at King Saud Medical City in Riyadh, Saudi Arabia, between August 2022 and August 2023 were included in this retrospective analysis. Every adult patient, who met the American Diabetes Association\'s requirements for DKA diagnosis and was at least 18 years old, was included.
Results In the final analysis, we included 218 patients with DKA, of whom 56 (25.6) were under ICU care. The patients admitted to the ICU had higher BMI and were more likely to be male than non-ICU patients, they were also having advanced age. DKA patients with type 2 diabetes mellitus (T2DM) had a higher likelihood of ICU admission than those with T1D. In patients with DKA needed ICU care, WBC counts were higher, as were urea level, and CRP. Compared to patients who did not need ICU admission, those who needed to be admitted had lower venous pH level and bicarbonate levels. Furthermore, 3.5% of ICU-admitted patients died in hospital, compared to 0 deaths among non-ICU admitted patients.
Conclusion: Of all patients with DKA, 25.6% needed ICU. Some factors that indicate a patient\'s likelihood of needing an ICU were; T2DM, advanced age, an infectious cause, newly diagnosed diabetes, and moderate or severe DKA.
Sales Promotion Brand Barenbliss Melalui TikTok
Authors: Koeswanto Angelica , Putranto Teguh Dwi , Budiman Devani Hizkia , , Enjelita , Equeena Karmelia
Published: December 2023

The development of internet-based technology has encouraged many companies to use social media as a marketing tool. In Indonesia, TikTok is one of the most popular social media platforms and is widely used by the public for creative activities, including selling products or uploading everyday content. Sales promotion is one of the ways used by sellers to make consumers interested in buying the product being promoted. One of the important elements in modern marketing is sales promotion, which includes strategies to increase product or service sales by offering attractive incentives to potential buyers. Sales promotion works simultaneously with other elements in the marketing mix such as product, price and distribution (place). This study aims to determine the sales promotion of the Barenbliss brand on the TikTok application. This study used a qualitative approach using content analysis methods. The research data collected is the result of observations and documents (TikTok videos). The main finding of this study is that 11 sales promotion videos were found on the Barenbliss account on the Tiktok application from early to mid 2023. Based on the results of research observations, it was concluded that the type of sales promotion that customers are most interested in is discounts or discounts, as well as giving gifts in the form of products Barenbliss through participating in a challenge.

Keywords: Sales Promotion, Barenbliss, Content Analysis, TikTok.
PENGARUH KUALITAS PRODUK DAN PROMOSI PRODUK TERHADAP KEPUTUSAN PEMBELIAN (STUDI EMPIRIS PADA PT. TRI SAKTI MOTOR PAMEKASAN)
Authors: Herman Djaja Moh. , Puji Rahayu Runik
Published: December 2023

Penelitian ini bertujuan untuk mengetahui pengaruh Kualitas Produk dan Promosi Produk terhadap Keputusan Pembelian: Studi Empiris pada PT. Tri Sakti Motor Pamekasan. Metode yang digunakan dalam penelitian ini menggunakan analisis regresi berganda. Data yang digunakan adalah data primer melalui pengumpulan kuesioner pada 75 pelanggan PT. Tri Sakti Motor Pamekasan. Penyelidikan empiris menunjukan bahwa kualitas produk dan kekuatan promosi memiliki pengaruh yang kuat terhadap keputusan pembelian. Kualitas produk yang baik disertai dengan daya promosi yang terbukti memperkuat keputusan pelanggan untuk membeli. Penelitian ini berguna untuk mendorong manajemen PT. Tri Sakti Motor Pamekasan untuk memperhatikan promosi mereka agar tepat sasaran dan menjangkau pasar mereka. Dengan kualitas produk yang sangat baik, manajemen perlu memperhatikan untuk memberikan kepercayaan kepada pelanggan agar membeli di tempat yang tepat.
Os internatos e a Educação de Mulheres nos Romances de Escritoras Paraenses
Authors: Alves Laura Maria Silva Araujo , Conceição Lília Batista da
Published: December 2023

O presente artigo tem como objetivo analisar a educação de mulheres nos internatos, a partir de produções literárias de Eneida de Moraes, Lindanor Celina e Maria Lúcia Medeiros. Essa investigação justifica-se pela importância de fomentar discussões relevantes sobre a educação feminina nos internatos durante o século XX no Norte do país, especialmente em Belém (PA), por meio de fontes literárias. Tendo em vista essas discussões, o embasamento teórico se fundamenta em Bourdieu (1996) e (2004), Volóchinov (2021) e assim por diante. Nesta perspectiva, criar internatos educativos para mulheres foi uma tentativa de conquistar a hegemonia no campo da educação na Amazônia, pois não era um ideário de educação moderna, mas em acreditar na regeneração da sociedade pela educação intelectual, moral e religiosa para a educação feminina
Case report of splenic infarction in a child with biliary atresia
Authors: Baldanza Patrícia , Cunha Eduarda , Hessel Gabriel , Brandão Maria Angela
Published: December 2023

This case report is intended to describe a rare case of splenic infarction (SI) associated with biliary atresia, which contributed to the worsening of the prognosis. In this case study, a boy diagnosed with biliary atresia underwent the Kasai procedure at the age of 3 months. The patient presented an intense abdominal pain, ascites and fever at the age of 6 years. A computed tomography (CT) scan showed enlargement of the spleen and an image suggestive of SI. The symptoms improved with the administration of antibiotics, analgesics, while ascites decreased with the use of diuretics. Liver transplantation was indicated. SI is an extremely rare event characterized by vessel occlusion, parenchymal ischemia and tissue necrosis. The symptoms are non-specific and may be confounding factors with other causes of acute abdominal pain. Splenomegaly-inducing diseases may be a risk factor. There are few case reports of SI and cirrhosis of different etiologies in childhood. Abdominal CT scan with intravenous contrast is the imaging modality of choice and the treatment ranges from supportive care to splenectomy. Despite being a rare condition, its knowledge is extremely important, as it allows early clinical suspicion, with immediate institution of treatment, which may interfere with the prognosis.
Effect of High Cell Density to Lipid Content Microalgae Chlorella vulgaris on Photoautotrophic Cultivation
Authors: Pamungkas Kevin Dyo , Anam Khairul , Budiati Titik
Published: December 2023

Chlorella vulgaris is one of microalgae types that has essential ingredients beneficial tohumans, such as being a source of good lipid. Chlorella sp. have high lipid content, up to30%, under autotrophic conditions considered as a promising candidate for commercial lipidproduction due to its fast growth and easy cultivation. High cell density sedimentation can beinvestigated as a starving method in cultivation to make microalgae conditions less favorablein obtaining nutrient to lipid accumulation. Starving is one of the stress conditions carried outwith the aim of reducing nutrients in the microalgae cultivation process. The aim of this studywas to determine the effect of high cell density on increasing lipid content in Chlorellavulgaris. The results of this study showed that high cell density method affected theproductivity of Chlorella vulgaris biomass. The data obtained were analyzed using ANOVAα=0.05. The highest productivity and lipid content was obtained from the control sample witha biomass value of 0.36±0.03 g/l and a lipid content of 56.2±4.6% (P<0.05). The conclusionof this study is high cell density may not increase the production of lipid content fromChlorella vulgaris
Organoleptic and Nutritions Observation of Monosodium Glutamate (MSG)-Free Instant Noodle Seasoning With Soto Padang
Authors: Rahma Yanti Nika , Syukri Daimon , Arlius Feri , Fahmy Khandra , Fatma Nanda Ririn
Published: December 2023

This research is an exploratory study. In this study, instant noodle seasoning was made from natural spices, without the addition of synthetic flavorings and preservatives. If monosodium glutamate (MSG) is consumed beyond the limit and consumed continuously for a long period of time, it will cause various side effects. MSG consumed by someone who cannot tolerate more than 3g/day can have adverse health effects. The purpose of this research is to develop Padang Soto flavored instant noodles using natural spices and without using synthetic flavoring Monosodium Glutamate (MSG). In this study, 4 formulas were made, coded as formula 1, formula 2, formula 3 and formula 4. The results showed that the panelists' preference for the color of instant noodles in formula 4 was 4.05. The panelists' favorite score for the aroma of instant noodle seasoning is highest in formula 4, which is 3.95. As for the taste results obtained, it is known that the panelists' favorite score for the taste of instant noodle seasoning is highest in formula 4, namely 4.05. From the results of the research, a dry seasoning with the code formula 4 has been produced that is delicious based on organoleptic analysis which can be used as a seasoning for instant noodle food products with instant Padang soup flavor. for proximate analysis, the best is also in formula 4, obtained water content of 3.85%, ash content of 1.66%, fat content of 1.29%, and protein content of 7.39%.
É POSSÍVEL UM JORNALISMO ATIVISTA?
Authors: Barsotti Adriana , Vieira Agostinho
Published: December 2023

RESUMO – A objetividade ajudou a consolidar a ideia de que o jornalista deveria ser um observador neutro da realidade. Um dos cânones do jornalismo, a estratégia, método ou ritual sofre críticas desde o século passado, já que os fatos são relatados mediante seleção, hierarquização e interpretação. Marcado por uma atuação pragmática-funcional, o ethos profissional, entretanto, impedia a reflexão acerca das práticas. No século XXI, no entanto, o discurso da objetividade vem sendo cada vez mais questionado, principalmente pelos “novos arranjos” jornalísticos (Nonato et al., 2018), que defendem o engajamento em torno de causas. A hipótese – confirmada pelo artigo – é que tais iniciativas estejam contribuindo para o tensionamento do ethos profissional. No contexto do novo ecossistema jornalístico, a tomada de posição passa a ser um valor a ser perseguido, e não mais uma transgressão deontológica. Para verificá-la, foram entrevistados nove jornalistas desses “novos arranjos”.
ABSTRACT – Objectivity helped to consolidate the idea that the journalist should be a neutral observer of reality. One of the canons of journalism, the strategy, method or ritual has been criticized over the last century, since facts are reported through selection, hierarchy and interpretation. The professional ethos, however, has been always marked by a pragmatic-functional performance that prevented reflection on the practices. In the 21st century, however, the discourse of objectivity has been increasingly scrutinised, especially by the “new journalistic arrangements” (Nonato et al., 2018) which advocate commitment to causes. The hypothesis – confirmed by the article – is that these initiatives are helping to put a strain on journalists’ professional ethos. In the context of the new journalistic ecosystem, taking a stand on causes becomes a value to be pursued, and no longer a deontological transgression. To verify it, nine journalists of these “new arrangements” were interviewed.
RESUMEN – La objetividad ayudó a consolidar la idea de que el periodista debe ser un observador neutral de la realidad. Uno de los cánones del periodismo, la estrategia, método o ritual ha sido criticado desde el siglo pasado, ya que los hechos son informados a través de la selección, jerarquía e interpretación. Marcado por una actuación pragmático-funcional, el ethos profesional impidió la reflexión sobre las prácticas. En el siglo XXI, sin embargo, el discurso de la objetividad se ha visto cada vez más cuestionado, especialmente por los “nuevos arreglos periodísticos” (Nonato et al., 2018), que abogan por causas. La hipótesis – confirmada por el artículo – es que estas iniciativas están contribuyendo a la tensión del ethos profesional. En el contexto del nuevo ecosistema periodístico, tomar partido se convierte en un valor a perseguir, y ya no en una transgresión deontológica. Para comprobarlo, se entrevistó a nueve periodistas de estos “nuevos arreglos”.
MOLECULAR GENETIC AND FUNCTIONAL ANALYSIS OF THE RAP-PHR SIGNALING SYSTEM OF THE PLASMID PBS72 OF BACILLUS SUBTILIS BACTERIA
Authors:   Belarusian State University, Minsk, Gurinovich A.S. , Titok M.A.
Published: December 2023

The Rap-Phr quorum sensing signaling system of the pBS72 plasmid is characterized by functional features. When the rap-phr genes in the pBS72 plasmid were disrupted, the efficiency of sporulation increased 2-fold, and when the mutant plasmid was transferred conjugatively, the number of donor cells decreased 10-fold after 3 and 4 hours and 100-fold after 24 hours of crossing. The number of transconjugants remained unchanged.
EFFECT OF THE NUMBER OF STEMNESS GENE AMPLIFICATIONS ON THEIR EXPRESSION LEVEL AND SUBPOPULATION COMPOSITION OF CELL LINES AND TUMORS OF BREAST CANCER PATIENTS
Authors:   Tomsk Cancer Research Institute, Dolgasheva D.S. , Kravtsova E.A. , Tsydenova I.A. , Gaptulbarova K.A. , Nevskaya K.V. , Pershina A.G. , Litvyakov N.V. ,   Siberian State Medical University, Tomsk
Published: December 2023

Metastatic disease is the main cause of death in cancer patients; therefore, it is relevant to study various mechanisms of metastasis. The aim of this work is to study the influence of the number of stemness gene amplifications on the subpopulation composition of tumor cell lines, as well as to establish the dependence of the level of stemness gene expression on the number of amplifications in cell lines and tumors of breast cancer patients.
DIFFERENTIATION OF BOS GRUNNIENS AND BOS TAURUS BASED ON CEP112 (CCDC46) GENE POLYMORPHISM
Authors:   Scientific Research Institute of Molecular Biology and Medicine, Bishkek, Kyrgyzstan, Isakova Zh.T. , Chekirov K.B. , Kipen V.N. ,   Institute of Genetics and Cytology of the NAS of Belarus, Minsk
Published: December 2023

For the first time in the Kyrgyz Republic, the differentiating potential of SNP Chr.19:g.63181970C>G in the CEP112 (CCDC46) gene for distinguishing between Bos grunniens and Bos taurus was confirmed.
Y CHROMOSOME MICRODELETIONS INVOLVING THE AZFB REGION IN RUSSIAN INFERTILE MEN
Authors:   Research Centre for Medical Genetics, Moscow, Lipatova E.A. , Shtaut M.I. , Solovova O.A. , Sorokina T.M. , Kazaryan M.S. , Schagina O.A. , Polyakov A.V. , Chernykh V.B.
Published: December 2023

The pattern of microdeletions of the long arm of the Y chromosome in the AZFb region was determined among 165 men with infertility. AZFb deletions were found in 25 % of them, of which complete AZFb deletions (P5/proximal P1, P4/proximal P1) accounted for 22 %, partial AZFb deletions — 3 %. AZFb+c deletions in 75 % of patients, of which complete AZFb+c were 98 %, partial AZFb + complete AZFc were 2 %. Breakpoints allowed us to clarify the size and localization of deletions capturing the palindromic region of the Y chromosome for 55 samples.
GENE REPRESSION USING THE DCAS12 PROTEIN IN A MODEL OBJECT DROSOPHILA MELANOGASTER
Authors:   Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Motorina D.M. , Battulina N.V. ,   Novosibirsk State University
Published: December 2023

To study the functions of genes, methods enabling precise and predictable control of the expression of the desired genes are required. The aim of this project is to develop an effective system for controlled and directed repression of transcription of target genes. To do that, the Cas12 protein, which does not have DNA nuclease activity and fused with various repressing factors will be attracted using guide RNAs to the regulatory regions of the genes followed by their inactivation.
EVALUATION OF CHANGES IN THE MITOCHONDRIAL ARCHITECTURE IN ASTROCYTES IN AN IN VITRO MODEL OF ALZHEIMER’S DISEASE
Authors:   Lobachevsky State University of Nizhny Novgorod, Okhalnikov A.D. , Motorina A.O. , Gavrish M.S. , Babaev A.A.
Published: December 2023

Alzheimer’s disease is a neurodegenerative disease whose pathogenesis is inextricably linked with a long-term disruption of metabolic processes in neuronal and glial cells. According to the literature data, mitochondrial dysfunction contributes to the activation of various signaling mechanisms leading to reprogramming of cell metabolism, which contributes to the development of the disease.
ADAPTATION OF THE CHAPERONE MACHINE OF HUMAN FIBROSARCOMA HT1080 CELLS TO THE LOSS OF HSP90Α AS A RESULT OF THE KNOCKOUT OF THE HSP90AA1 GENE
Authors:   Institute of Cell Biophysics RAS, Pushchino, Petrenko V.S. , Vrublevskaya V.V. , Zhmurina M.A. , Skarga Yu.Yu. , Morenkov O.S.
Published: December 2023

Knockout of the HSP90AA1 gene encoding Hsp90α in HT1080 human fibrosarcoma cells was accompanied by adaptation of the cellular chaperone machine to Hsp90α loss. Adaptation included increased expression of Hsp90β, key Hsp90 co-chaperones, chaperones and co-chaperones of the Hsp70/Hsp40 complex, components of the TRiC/CCT complex, prefoldins, prefoldin-like PFDL, R2TP, and R2SP chaperone complexes, as well as key mitochondrial chaperones and chaperonins.
The effectiveness of using a combination of laser radiation with wavelengths of 585 and 1064 nm in the treatment of patients with basal cell skin cancer
Authors: Saytburkhanov Rifat R. , Plakhova Xenia I. , Kondrakhina Irina N. , Kubanov Аlexey A.
Published: December 2023

Background. Basal cell skin cancer is the most common skin malignancy, and its incidence has been rapidly increasing throughout the world in recent decades.
Aims. To study the effectiveness of using laser radiation with a wavelength of 585 nm and 1064 nm in a sequential (sequential) combined mode for the treatment of patients with superficial and nodular forms of basal cell skin cancer using dermoscopic and confocal microscopic in vivo examination.
Materials and methods. The study included 30 patients with histologically confirmed basal cell skin cancer, who received treatment in the conditions of the Consultative and Diagnostic Center of the State Research Center of Dermatovenereology and Cosmetology of Russian Ministry of Health in the period from 2020 to 2021, using a pulsed dye laser (wavelength 585 nm) and long-pulse neodymium laser (wavelength 1064 nm).
Results. In the subgroup of patients with the nodular form of basal cell carcinoma (n = 15): in 11 patients the duration of treatment was 1 procedure, in 3 patients – 2 procedures, in 1 patient — 3 procedures. In the subgroup of patients with superficial basal cell carcinoma (n = 15 ): in 2 patients the course of treatment was 2 procedures, in 13 patients — 1 procedure. Patients have now completed treatment and are being followed up with visits every 6 months for 3 years. According to dermoscopic and confocal microscopic studies, there is no evidence of continued growth and relapse in all patients. No side effects or adverse events were recorded.
Conclusions. The combined sequential use of 585 nm and 1064 nm laser radiation may be an effective treatment for patients with low-risk basal cell skin cancer of recurrence. The results of our study indicate that clinical tumor removal without scarring can be achieved and may be an alternative treatment option for those who do not wish to use traditional surgical approaches.
The Paradoxical Role of Mediators in the Armenia-Azerbaijan Conflict: Prospects and Concerns
Authors: Rauf Sarwat
Published: December 2023

This paper explores the underlying factors that pushed Russia, the European Union (EU), Türkiye, and somehow the United States U.S. to offer mediation to settle the conflict between Armenia and Azerbaijan. The eruption of the fierce clashes between Azerbaijan and Armenia ended the war that happened in 2020 when Russia brokered the ceasefire. However, Russia’s war in Ukraine was signaling renewed fighting in Nagorno-Karabakh. Hence, some actors started to step into the hostility to facilitate diplomatic efforts to lower the temperatures of the conflicting parties. Meanwhile, Azerbaijan made a military assault on Artsakh in 2023 and gained a final victory over Nagorno Karabakh. Amid tension, the EU, Russia, and Türkiye will hold a responsible role and bring hopes that diplomacy may bring Azerbaijan and Armenia closer to peace, and an eventual settlement will ensue. The research demonstrates that a new geopolitical change has been taking place in the South Caucasus region, which is causing complexities amid some options set by the mediators.
Israel’s Fateful March: From Settler Colonialism to Genocidal State
Authors: Aral Berdal
Published: December 2023

This article delves into the legal discussions surrounding the crisis unleashed by the military operation launched on October 7, 2023, in Southern Israel by Palestinian forces of the resistance based in Gaza. Israel considered this a “terrorist attack,” asserted the right of self-defense, declared war on Gazans, and started the continuous and indiscriminate bombardment of Gaza. As a result, Gaza has become the new Dresden, in which thousands have been killed and tens of thousands injured. This article is an attempt to answer the following questions to illuminate the legal issues surrounding the current crisis and the broader context of Israel’s legal status as a state and its territorial claims: Was the Palestinian offensive in Southern Israel an instance of terrorism and/or an act of aggression? Which side of the conflict can rightfully claim the right of self-defense? Did Israel commit genocide in Gaza? Do Israel’s statehood and territorial claims rest on firm legal grounds? Is it legally sensible to argue that Israel is a threat to international peace and security?
Security Aspect of the Integration in Turkic World under the Organization of Turkic States
Authors: Sarı Buğra
Published: December 2023

The Turkic states began their collaboration in 1992. Over time, this cooperation has grown deeper, resulting in the establishment of the Organization of Turkic States (OTS), which has evolved into a comprehensive international organization. The member states of OTS have expressed their commitment to pursuing coordinated policies on security matters that are of mutual interest. As a result, the security dimension has become increasingly prominent within the multidimensional areas of cooperation within OTS in recent years. In light of this, the present study aims to explore the positive outcomes of enhanced and fortified security collaboration among Turkic states under the umbrella of OTS. Specifically, the study will focus on systemic security, regional security, and key security issues such as counter-terrorism and military capacity, shedding light on the potential benefits derived from these collaborative efforts.
Native Canadian daily life in the Northwest Passage context
Authors: Mitko A. V. , Sidorov V. K.
Published: December 2023

This article explores the connection between the indigenous populations of the North and the Canadian government regarding the Northwest Passage in the Arctic region. The significance of indigenous representation in managing the Northwest Passage is emphasized. The challenges faced by small indigenous groups of the Canadian Arctic are addressed, as well as possible solutions through series of mutually beneficial economic and political proposals. Inuit involvement in the management of marine ecosystem goes beyond Canada’s borders. The Arctic Council has demonstrated that permanent participants from Northern Indigenous communities can significantly influence government, especially on Arctic issues. The days when the Arctic was on the outskirts of global political affairs are gone, as are the days of Canada’s previous passive stance towards its assertions of historically internal waters within the Northwest Passage. Advancing the interests of Indigenous peoples of the North is a well-established Canadian position. The utilization of the Arctic territory by these peoples serves as the backbone of Canada’s Arctic State Policy, consistently articulated by the Government of Canada.
ON THE USE OF BIOMETRIC TECHNOLOGIES BY INVESTIGATOR WHILE IDENTIFYING THE PERSON COMMITTED THE CRIME
Authors: Кулаевский А.В.
Published: December 2023

В статье проанализирована проблема использования биометрических технологий при проведении правоохранительными органами оперативного распознавания. Автором исследованы сферы применения биометрических технологий правоохранительными органами. Раскрыты проблемы использования биометрических технологий при установлении лица, совершившего преступление.

The article provides analysis of the use of biometric technologies by law enforcement authorities in the course of conducting operational recognition. The author examines fields of application of biometric technologies by law enforcement bodies. The study focuses on problematic issues related to the use of biometric technologies while identifying the person committed the crime.
MANAGEMENT OF ENSURING ECONOMIC SECURITY OF RUSSIAN FEDERATION IN INTEGRATION COOPERATION UNDER RESTRICTIONS
Authors: Назаров П.В. , Редькина Т.М. , Смирнов А.А.
Published: December 2023

Целью статьи является обоснование мер управленческого характера, обеспечивающих рост российской экономики при сохранении ее суверенитета и национальной безопасности в условиях ограничений, необходимости импортозамещения и поиска новых стратегических партнеров при налаживании интеграционных взаимодействий. В статье проанализировано значение текущих результатов сотрудничества с азиатскими странами как для экономики России, так и для стран-участниц объединений, доказана взаимосвязь экономической безопасности и интеграционного взаимодействия, обоснована необходимость применения комплексных управленческих решений, формирующих основу для эффективного развития экономики России в новых условиях хозяйствования.

The research is aimed at substantiating the managerial measures to ensure the growth of Russian economy while preserving its sovereignty and national security under restrictions, the need for import substitution and the search of new strategic partners in integration cooperation. We analyze the significance of current results of cooperation with Asian countries both for the Russian economy and for the member countries of the associations. We prove the correlation between economic security and integration cooperation and substantiate the need to apply integrated management solutions making the basis for the effective development of Russian economy under new economic conditions.
TRANSFORMATION OF STRUCTURE OF RUSSIAN REAL ECONOMY SECTOR: ROLE OF PLAN AND MARKET
Authors: Камышова А.Б. , Кондратьев Л.Н.
Published: December 2023

Статья представляет собой научное исследование, посвященное проблеме реструктуризации реального сектора экономики в условиях санкций. Особое место отводится политике импортозамещения, целью которой является создание новых продуктов и новых производств высокотехнологичной направленности. Авторами предлагается подход к государственному регулированию процесса создания новых высокотехнологичных производств в условиях санкций посредством обоснования усиления плана.

We consider the problem of restructuring the real sector of the economy under sanctions. A special place is given to the policy of import substitution aimed at creating new products and new high-tech industries. The authors present an approach to the state regulation of creating new high-tech industries under sanctions by substantiating the growing role of planning.
Estrategias didácticas inclusivas para la educación integral de la sexualidad en adolescentes
Authors: Unda-Villafuerte Fernando Santiago
Published: December 2023

La adolescencia no es homogénea, existen diferencias y necesidades configuradas por género, etnia o capacidades particulares. Este estudio consideró como problema de investigación: ¿qué estrategias didácticas, permiten abordar contenidos de educación integral de la sexualidad, desde la diversidad de adolescentes presentes en el aula? El objetivo fue identificar estrategias en educación integral en sexualidad con adolescentes, considerando su inclusión social por género, interculturalidad y funcionalidad. La metodología partió del paradigma interpretativo con enfoque cualitativo; como método la revisión sistémica y estudio de casos; y las técnicas empleadas revisión documental y entrevista semiestructurada. Se concluye que las estrategias inclusivas, miradas como innovaciones pedagógicas, miran la sexualidad como derecho humano en el marco de la educación para todos, su fin es la toma de decisiones responsables. Se evidencian problemáticas y necesidades diferentes en educación para la sexualidad entre hombres y mujeres que cuestionan entradas de “mayoría” y “normalidad”.
¿Qué piensan los niños sobre la evaluación? Ciudad Barranquilla, Colombia
Authors: Lopesierra Palacios Angie , Borjas Mónica Patricia , Herrón Gloria Mauricio
Published: December 2023

Se aborda la evaluación como una práctica sustancial desarrollado en centros educativos, cuyas experiencias impactan directamente en la concepción evaluativa en estudiantes infantes. El propósito de la investigación fue indagar dichas concepciones en niños y niñas colombianos con edades entre los 4 y 12 años de la ciudad de Barranquilla, Colombia. Se aplica una metodología cualitativa de corte interpretativo y un protocolo de entrevista con preguntas semi-estructuradas. Los resultados, permitieron identificar que la mayoría de los participantes posee una concepción ligada a enfoques técnicos sobre la naturaleza y el propósito de la evaluación, la cual se encuentra alineada con prácticas tradicionales en torno a la misma.
Perspectivas de la investigación formativa en un programa de enfermería de una universidad colombiana
Authors: Galán-González Edna Fabiola , Mesa Rodríguez Sandra Milena , Campos Quintero Liliana , Mahecha-Gamboa Eidy Lorena
Published: December 2023

La producción científica en enfermería es fundamental para el crecimiento disciplinar, por ello es necesario potenciarlo a través de la generación de nuevo conocimiento. El objetivo de este manuscrito fue caracterizar los trabajos de grado de un programa de enfermería con una universidad privada del Sur de Colombia, para determinar las perspectivas futuras. Se desarrolló un estudio documental de tipo bibliométrico con la producción investigativa de los estudiantes de enfermería, en el cual se analizaron 113 trabajos ejecutados entre 2017 y 2021. La mayoría se realizaron con pacientes hospitalizados y profesionales de la salud, fueron enmarcados en modelos y teorías de enfermería con predominio Dorothea Orem, se centraron en temas como la calidad en la atención y los conocimientos en salud.
Proyección futura de las agencias de viajes presenciales en España: la percepción de los usuarios
Authors: Pallas Ángel Rodríguez
Published: December 2023

El futuro de las agencias de viajes tradicionales desde la perspectiva de usuarios presenciales y online fue abordado. En este trabajo de investigación se estudió si las agencias físicas, están preparadas tecnológicamente para atender a los consumidores virtuales, descubrir la valoración de la experiencia de compra, en consumidores online y presenciales, además de vislumbrar la proyección futura de las agencias físicas españolas. Se empleó una metodología de tipo cuantitativo, explicativo y ex post facto, siguiendo el método hipotético-deductivo que permite contrastar los objetivos y las hipótesis planteadas. Se utilizó muestreo por conveniencia y no probabilístico con 879 individuos, 44 % hombres y 56 % mujeres, correspondiente al 2019. En la elaboración del cuestionario, se contó con 3 expertos, un pretest, y se consideró un índice de consistencia interna alfa de Cronbach, para valorar la fiabilidad del cuestionario con el fin de aplicar técnicas de inferencia. Se concluye que las agencias tradicionales para no verse desplazadas deben considerar la multicanalidad y desarrollar la omnicanalidad. Los consumidores valoran la experiencia, seguridad en las transacciones, comodidad, asesoramiento y el trato cercano, características decisivas de las agencias tradicionales, sin sopesar el coste económico; aunque, el canal online es más empleado, las agencias presenciales una vez especializadas en tecnologías alineadas al nuevo perfil de consumidor tienen una proyección a futuro.
Stereodivergent, Kinetically Controlled Isomerization of Terminal Alkenes via Nickel Catalysis
Authors: Rubel Camille , Ravn Anne , Ho Hang Chi , Yang Shenghua , Li Zi-Qi , Engle Keary , Vantourout Julien
Published: December 2023

Because internal alkenes are more challenging synthetic targets than terminal alkenes, metal-catalyzed olefin mono-transposition (i.e., positional isomerization) approaches have emerged to afford valuable E- or Z- internal alkenes from their complementary terminal alkene feedstocks. However, the applicability of these methods has been hampered by lack of generality, commercial availability of precatalysts, and scalability. Here, we report a nickel-catalyzed platform for the stereodivergent E/Z-selective synthesis of internal alkenes at room temperature. Commercial reagents enable this one-carbon transposition of terminal alkenes to valuable E- or Z-internal alkenes via a Ni–H-mediated insertion/elimination mechanism. Though the mechanistic regime is the same in both systems, the underlying pathways that lead each of the active catalysts are distinct, with the Z-selective catalyst forming from comproportionation of an oxidative addition complex followed by disproportionation with substrate and the E-selective catalyst forming from protonation of the metal by the trialkylphosphonium salt additive. In each case, ligand sterics and denticity control stereochemistry and prevent over-isomerization.
Rational Design of Molecular Glues: Breakthroughs and Perspectives
Authors: An Juzeng , Zhang Xiaojun
Published: December 2023

CRBN is a substrate receptor for the Cullin Ring E3 ubiquitin ligase 4 (CRL4) complex. It has been observed that CRBN can be exploited by small molecules to facilitate the recruitment and ubiquitination of non-natural CRL4 substrates, resulting in the degradation of neo-substrate through the ubiquitin-proteasome system. This phenomenon, known as molecular glue induced protein degradation, has emerged as an innovative therapeutic approach in contrast to traditional small-molecule drugs. One key advantage of molecular glues, in comparison to conventional small-molecule drugs adhering to Lipinski's Rule of Five, is their ability to operate without the necessity for specific binding pockets on target proteins. This unique characteristic empowers molecular glues to interact with conventionally intractable protein targets, such as transcription factors and scaffold proteins. The ability to induce the degradation of these previously elusive targets by hijacking the ubiquitin-proteasome system presents a promising avenue for the treatment of recalcitrant diseases. Nevertheless, the rational design of molecular glues remains a formidable challenge due to the limited understanding of their mechanisms and actions. This review offers an overview of recent advances and breakthroughs in the field of CRBN-based molecular glues, while also exploring the prospects for a systematic approach to designing these compounds.
Aziridination via Nitrogen-Atom Transfer to Olefins from Photoexcited Azoxy-Triazenes
Authors: Mitchell Joshua , Hussain Waseem , Bansode Ajay , O'Connor Ryan , Parasram Marvin
Published: December 2023

Herein, we report that readily accessible azoxy-triazenes can serve as nitrogen atom sources under visible-light excitation for the efficient aziridination of alkenes. This approach eliminates the need for external oxidants, precious transition metals, and photocatalysts, marking a departure from conventional methods. The versatility of this transformation extends to the selective aziridination of both activated and unactivated multi-substituted alkenes of varying electronic profiles. Notably, this process avoids the formation of competing C–H insertion products. The described protocol is operationally simple, scalable, and adaptable to photoflow conditions. Mechanistic studies support that the photofragmentation of azoxy-triazenes results in the generation of a free singlet nitrene that governs the observed chemoselectivity and stereospecificity of the reaction. Our findings contribute to the advancement of sustainable and practical methodologies for the synthesis of nitrogen-containing compounds, showcasing the potential for broader applications in synthetic chemistry.
Weak Light H2O2 Photosynthesis from H2O and O2 by Carbon Nitrides with Piezoelectric Effect for Tumor Therapy
Authors: Ma Jin , Peng Cheng , Peng Xiaoxiao , Liang Sicheng , Zhou Zhixin , Wu Kaiqing , Chen Ran , Liu Songqin , Shen Yanfei , Ma Haibo , Zhang Yuanjian
Published: December 2023

Artificial photocatalysis could be the choice of technology for producing H2O2 considering the abundant sunlight exposure in global regions. However, despite recent technological advances, current catalyst systems still remain challenging that the need for high density sunlight, poor selectivity/activity and unfavourable thermodynamics. Here, we reported that carbon nitride with extended conjugation C5N2 harness piezoelectric-effect to both change the selectivity/activity of WOR and photogenerated charge kinetics in non-sacrificial H2O2 production. Here, C5N2 achieves a H2O2 photosynthesis rate of 918.4 µM/h and a solar-to-chemical conversion efficiency of 2.6% under a weak sunlight (0.1 sun) and ultrasonic irradiation. Additionally, C5N2 exhibited by far the highest piezocatalytic H2O2 synthesis activity at rates up to 480.1 µM/h. The new strategy was further applied to efficient SPCDT and water purification in low density light input conditions. This work not only presents piezoelectric-effect of carbon nitride to harness the selectivity/activity of WOR and the migration/transport of photogenerated charges as an available innovative concept in energy, but also sheds light on rising potentials in health and environment.
Sequence and structural analysis of main protease Mpro mutants of SARS CoV-2 from variant of concern (VoCs)
Authors: KHAN MOHD
Published: December 2023

In light of the emergence of new and potentially more virulent SARS-CoV-2 variants, an in-depth analysis of the main protease (Mpro) or 3CLpro, a critical target for COVID-19 therapy due to its essential role in viral replication, was conducted. This study focused on the alpha, beta, gamma, delta, and omicron variants, comparing them to the reference sequence (Wuhan-Hu-1). The comprehensive analysis of the mutational landscape of SARS-CoV-2 Mpro across Variants of Concern (VOCs) provides valuable insights into the evolving nature of the virus. The study utilized a substantial dataset of 222,980 sequences (quality data) and created a library of a total of 51,733 mutations for the Mpro protein. The distribution of mutations varied among the variants, with distinct patterns observed. Certain regions crucial for drug binding and protease function showed relatively fewer mutation rates, unlike the interdomain site, which exhibited higher mutation rates compared to catalytic and dimeric interface sites. Notably, the Omicron variant displayed the prevalent P132H mutation, while the Beta variant featured the prevalent K90R mutation. Furthermore, proline positions in Mpro were investigated, with mutations identified in ten out of thirteen positions, underscoring the potential impact on protein stability. Additionally, the catalytic site S1 sub-pocket was found to be less mutated, whereas the S3 sub-pocket was highly mutated. These findings suggest a critical role in maintaining the structural and functional integrity of Mpro, offering valuable insights for future research and therapeutic development.
Temporary trends and factors of birth rate in Ukraine: regional dimension
Authors: Sehida Kateryna , Karaichentseva Hanna
Published: December 2023

The demographic problem is surprisingly acute for Ukraine. Research trends factors and structural and dynamic features of birth rate will allow determining socio-economic and demographic trends, including their variations across regions. The purpose of the article is to establish regional features of modern trends and factors of fertility in Ukraine in the 21st century. The article presents an analysis of the dynamics of the birth rate in Ukraine based on the analysis of official statistics. Periods of minimum and maximum values have been established taking into account the leading factors and differences by type of settlements. The characteristics of changes in the sex-age structure of the population of Ukraine and the age-related fertility rate in the context of leading factors and differences by types of settlements are given.

Based on the standardization of demographic coefficients, the degree of influence of internal factors affecting the birth rate in the regions of Ukraine was determined. A significant share of births in older fertility groups was identified, which confirms the trends of the second demographic transition, the spread of the phenomenon of "late motherhood" and the so-called "pro-European" model of reproductive behavior, which is more characteristic of highly urbanized regions of Ukraine. On the basis of cluster analysis, regional peculiarities of trends and factors of fertility in Ukraine in the 21st century were revealed, as a result, five clusters were identified. The first cluster includes the capital. The second cluster includes Zakarpattya, Rivne, and Volyn regions, which have the most lively demographic behavior of the population and the preservation of traditional factors. The third cluster united Kharkiv, Sumy, Cherkasy, Chernihiv, Poltava, Zaporizhzhya and Dnipropetrovsk regions. The fourth cluster is represented by Odesa, Lviv, Chernivtsi and Ivano-Frankivsk regions. The fifth cluster includes Mykolaiv, Kirovohrad, Ternopil, Kyiv, Kherson, Zhytomyr, Khmelnytskyi, and Vinnytsia regions. Thus, internal territorial differences in the birth rate, in terms of regions of Ukraine, as well as urban and rural areas, are the result of the action of external and internal factors that had an impact during the studied period and were reflected in the course of demographic processes.
Problems of Transformation of Political Institutions After the War
Authors: Rushchenko Ihor
Published: December 2023

The purpose of this article is to examine potential trends in the development of the political system of Ukraine after the end of the Russia-Ukraine war. Social changes always take place taking into account both subjective and objective circumstances. Currently the Ukrainian state relies on three pillars for further transformation of political institutions: 1) the Ukrainian value-mental tradition, 2) our own experience of democratic development in recent decades, 3) the political will to embrace European values. The latter means that Ukraine voluntarily undertook the obligation to meet the Copenhagen criteria, including to demonstrate the stability of institutions guaranteeing democracy, rule of law, human rights and protection of minorities. In the political circles of Ukraine, there is a "plan to restart the state", which boils down to structural changes in the system of public administration. Ukraine needs qualitative changes in the system of political relations, it is necessary to eliminate the contradiction between the form and content of political institutions. Archaic practices, nepotism, eastern methods of holding power by suppressing the opposition, corruption in the state apparatus and purely criminal practices are hidden behind the modern facade. War not only destroys, but also gives impulses for development through the mobilization of the nation's forces. We have a chance to restart political institutions and consolidate new structures born of war. We must pay attention to the institution of national resistance, which, through the movement of territorial defense and the volunteer movement, led to a situation of social filtering. As a result, strata of people crystallized, for whom the public good is higher than selfish interests. It is important not to lose the energy of the masses after the war and to use the patriotic movement to build political institutions.
Metahistoricism in Vera Bogdanova’s novel “The Season of Poisoned Fruits”
Authors: Zalozna Kseniia
Published: December 2023

The purpose of the article is to trace the narrativization of historical events in Vera Bogdanova's novel The Season of Poisoned Fruit (2022), which focuses on the story of "forbidden" love between cousins. The relevance of the article stems from the fact that the novel has already become a significant phenomenon in contemporary Russian literature, but has not yet found its researchers. The novel's themes include the sickness of Russian society, militarization, extreme xenophobia, propaganda, domestic violence, and social rejection of otherness; through these problems, anti-military and liberal pathos emerges, so the novel should be considered part of a culture that is in opposition to the modern Russian regime. The range of problems in the novel revolves around different strategies for dealing with different personal and historical traumas; however, critics suggest that the generation of "thirtysomethings" does not share the historical trauma of childhood, as, for example, the older generation, which saw the collapse of the USSR as children.

The article demonstrates how the novel's text perceives the traumatic events of Russian and world history (the events in Moscow in 1993, the terrorist attacks in Moscow and London, the forest fires of 2010, etc.) through the prism of the perception of several representatives of the millennial generation ("the generation of thirty-somethings"). The article shows how state propaganda and hierarchized narrative of the story replace the protagonists' personal memories of events, which, in turn, become taboo. The intervention of a discourse that narrates the story in the spirit of Russian propaganda is made possible by the constant presence and unrelenting intensity of television intrusions into the protagonists' personal lives. It is assumed that the novel has several strategies for organizing the interaction between general and personal history, including (1) aggression and the search for those responsible for historical tragedies; (2) ignoring, (3) mystical metahistorical linking of historical and personal events.