bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular (cytogenetic diagnosis of Prader-Willi syndrome)
Authors: Zaletaev Dmitriy , Shilova Nadezhda , Musatova Viktoriya , Min'zhenkova Marina , Markova Zhanna , Kucev Sergey
Published: April 2023

This teaching aid is devoted to the theoretical and practical aspects of the genetic diagnosis of Prader-Willi syndrome and is compiled in accordance with the Federal State Educational Standard of Higher Education in the specialties 08/31/30 "genetics", 05/31/02 "pediatrics", 08/31/06 "laboratory genetics", 08/31/53 "endocrinology", 08.31.42 "neurology", 08.31.05 "clinical laboratory diagnostics" and the work programs of the Department of Medical Genetics of the IViDPO FGBNU "MGNTS", as well as taking into account the professional standards of doctors of the above specialties; scientific specialties 1.5.7. "genetics", 3.3.8. "clinical laboratory diagnostics", 3.1.21 "pediatrics", 3.1.19. "endocrinology" and 3.1.24. "neurology" in the preparation of scientific and pedagogical staff in graduate school.
The manual is intended for residents in the above specialties, graduate students in scientific specialties 1.5.7. "genetics", 3.1.21 "pediatrics", 3.3.8. "clinical laboratory diagnostics", 3.1.19. "endocrinology" and 3.1.24. "neurology", as well as for geneticists, pediatricians, endocrinologists, neurologists, laboratory geneticists and specialists in the field of clinical laboratory diagnostics when teaching them under advanced training programs. Published by the decision of the educational and methodological commission of the Institute of Higher and Additional Professional Education of the Federal State Budgetary Scientific Institution “Medical Genetic Research Center named after Academician N.P. Bochkov” dated 23.09.2022
3D-printing technology in creation of a needle guide for a convex ultrasound probe.
Authors:   N.I. Pirogov Clinic of High Medical Technologies, Saint-Petersburg State University, Gadzhiev N.K. ,   Saint-Petersburg, Russia, Gorgotsky I.A. ,   N.I. Pirogov Clinic of High Medical Technologies, Saint-Petersburg State University; Saint-Petersburg, Russia, Aloyan A.A. ,   N.I. Pirogov Clinic of High Medical Technologies, Saint-Petersburg State University; Saint-Petersburg, Russia, Piven N.V. ,   N.I. Pirogov Clinic of High Medical Technologies, Saint-Petersburg State University; Saint-Petersburg, Russia, Skarupa A.A. ,   General Medicine Faculty, Saint-Petersburg State University; Saint-Petersburg, Russia, Britov V.P. ,   Department of Equipment and Robotics for Plastics Processing, Saint-Petersburg State Institute of Technology; Saint-Petersburg, Russia, Martov A.G. ,   Department of Urology and Andrology, Biomedical University of Innovation and continuing education A.I. Burnasyan Federal Medical Biophysical Center, Lomonosov Moscow State University Medical Research and Educational Center; Moscow, Russia, Petrov A.D. ,   N.I. Pirogov Clinic of High Medical Technologies, Saint-Petersburg State Universit; Saint-Petersburg, Russia, Skarupa D.D. ,   N.I. Pirogov Clinic of High Medical Technologies, Saint-Petersburg State University; Saint-Petersburg, Russia
Published: April 2023

Introduction. Percutaneous surgery is one of the methods of surgical treatment of renal stones. The most difficult stage of the operation is the creation of percutaneous access to the pyelocaliceal system of the kidney. To facilitate access under ultrasound (US) guidance, it is customary to use a needle guide which is fixed to the US-probe. Taking into account the sanctions of the equipment manufacturing countries, Russian specialists may potentially find themselves in conditions of a shortage of components and particularly needle guide for ultrasound probes. In this regard, it was decided to develop the possibility of printing a needle guide for an ultrasound probe using 3Dprinting technology. Materials and methods. Using a handheld 3D laser scanner, a metal needle guide for the convex ultrasound probe was scanned, the necessary changes were made for use, and a plastic needle guide was created using 3D printing. Results. The needle, when passed into the grooves with preset angles of the printed needle guide, exactly matches the dotted aim on the monitor of the ultrasound machine, similar to the original probe. Conclusion. The use of 3D-printing in the absence of certain components, in particular, a needle guide for an ultrasound probe, allows to quickly obtain a working sample that is not inferior to the original one.
Impact of Credit Union Members’ Transaction Purposes and Items on Core Deposits: Cases of Gwangju and Jeonnam
Authors:   Korea Accounting Information Association, Kim Moon Tae
Published: April 2023

[Purpose] This study emphasized the importance of demand deposits, which are core deposits, to secure profitability of the credit union, and analyzed the effect on demand deposits when the first transaction purpose of the members is deposit transactions and the main transaction subject is ordinary deposits.
[Methodology] As of the end of June 2021, this study presented the results of correlation analysis, average difference analysis, and multiple regression analysis targeting 7,707 members of 25 regional credit unions located in Gwangju and Jeollanam－do.
[Findings] As a result of the empirical analysis, when the first transaction purpose was deposit transaction and the main transaction purpose was ordinary deposit, there was a significant positive correlation with the increase in demand deposits, and the group with the first transaction purpose was significantly higher. At last, multiple regression analysis showed when the first transaction purpose is deposit transaction and the main transaction purpose is ordinary deposit, it is a core deposit that is the basis for the profitability of the credit unions and has a positive effect on the average balance of demand deposits.
[Implications] In terms of accounting, research on the determinants of profitability for credit unions was very poor. This study will have a contribution as an initial study to verify the effect of transaction purpose and transaction subject that can affect demand deposit, which is a core deposit, as the basis of credit union profitability.
Modeling drugs’ dosage adjustments in responsible self-treatment of chronic diseases
Authors:   North-West State Medical University named after I.I. Mechnikov, St. Petersburg, Russian Federation, Gelman V. Ya.
Published: April 2023

Responsible self-treatment in chronic diseases involves adjustment of the drug’s dose depending on monitoring data. The aim of the study was to simulate the adjustment of dosage of drugs in responsible self-treatment of chronic diseases and to find methods for calculating current dosages. The methodological basis of the work were methods of mathematical modeling and control theory. The case of discrete control with the introduction of a feedback loop is considered. A method for calculating the dosage of a drug is proposed, taking into account the individual sensitivity of the patient and external uncontrolled influences. The use of the proposed method will improve the quality of control and, accordingly, the effectiveness of the treatment process.
Analysis of the Prevalence of Myopia in Medical Students
Authors:   Kazan State Medical University, Kazan, Russian Federation, Plotnikov D. Yu. , Agliullina S. T. ,   Kazan State Medical University, Kazan, Russian Federation, Ashryatova L. Sh. ,   Kazan State Medical University, Kazan, Russian Federation, Pankratova S. A. ,   Kazan State Medical University, Kazan, Russian Federation, Lushanina K. A. ,   Kazan State Medical University, Kazan, Russian Federation, Zakirov I. K. ,   Kazan State Medical University, Kazan, Russian Federation; Professorial Clinic of Kazan State Medical University, Kazan, Russian Federation, Shulaev A. V. ,   Kazan State Medical University, Kazan, Russian Federation
Published: April 2023

Myopia continues to be a serious public health problem due to the steady increase in the prevalence of the disease and the presence of serious complications leading to the loss of vision. The aim of the study was to investigate the prevalence of myopia among medical students. Materials and methods. A self-reported questionnaire was used to collect the myopia-related data in the 1st-6th year students of various faculties of Kazan State Medical University. The prevalence of myopia was assessed using the medical record of a patient receiving medical care on an outpatient basis. 352 medical records were processed, 323 of them were included in the study. Results. Myopia was detected in 69% of students, 2% had other eye diseases. 42% of students had mild myopia, 21% – moderate myopia, 6% – high myopia, 29% of respondents did not suffer from any eye diseases. According to our data, the prevalence of myopia among female students was 69%, among males – 66%. It was estimated that among students who use vision correction devices, 17% of students started wearing glasses/contact lenses at the age of 10, 43% – at the age of 10 to 15 years, 34% – at the age of 15 to 20 years, 6% of students started using vision correction devices being older than 20 years. Conclusion. The high prevalence of myopia among students of Kazan State Medical University (69%) was revealed. In most cases, myopia developed before entering the university; this demonstrates the need in prophylaxis of nearsightedness not only in students, but also in schoolchildren.
Pendekatan Integrated Coastal Management (ICM) dalam Pengelolaan ROB dan Banjir
Authors:   Pusat Kajian Sumberdaya Pesisir dan Lautan (PKSPL), IPB University, Christian Yoppie , Afandy Andy ,   Pusat Kajian Sumberdaya Pesisir dan Lautan (PKSPL), IPB University, Yonvitner Yonvitner ,   Pusat Kajian Sumberdaya Pesisir dan Lautan (PKSPL), IPB University,   Departemen Manajemen Sumberdaya Perairan, FPIK IPB University
Published: April 2023

Persoalan penanganan banjir rob dan limpasan di Kabupaten dan Kota Pekalongan bersifat kompleks karena melibatkan banyak pihak. Kondisi ini semakin berat dengan kapasitas adaptif berada pada tingkat Rendah-Sedang, dan persepsi risiko masyarakat pada level Rendah. Kajian PKSPL IPB (2021) memproyeksikan nilai kerugian dan kerusakan tahun 2030 mencapai Rp. 30,94 trilliun (penanganan business as usual). Sehingga perlu pendekatan ICM untuk mengidentifikasi solusi atas tantangan pembangunan melalui mekanisme pengambilan keputusan secara terpadu dan sistematis mulai dari perencanaan, inisiasi, implementasi, monitoring, evaluasi atas strategi dan program sebagai respon atas tantangan yang dihadapi masyarakat. Pendekatan ICM menyediakan panduan bagi semua aktor untuk menyusun rencana induk pengelolaan pesisir secara terpadu.
Penguatan Tata Kelola Perlindungan Buruh Migran Anak Buah Kapal (ABK) Indonesia di Kapal Ikan Asing
Authors:   Pusat Kajian Sumberdaya Pesisir dan Lautan (PKSPL), IPB University, Solihin Akhmad ,   Departemen Pemanfaatan Sumberdaya Perikanan, Fakultas Perikanan dan Ilmu Kelautan, IPB University, Mustofa Ahmad ,   World Wide Fund for Nature (WWF), Indonesia, Desyana Cut ,   World Wide Fund for Nature (WWF), Indonesia
Published: April 2023

Pekerjaan menjadi buruh migran pada kapal ikan asing masih menjadi tujuan utama pada beberapa wilayah Indonesia, khususnya masyarakat yang tinggal di wilayah pantai utara Jawa. Namun demikian, tingginya minat menjadi buruh migran ABK di kapal ikan asing belum disertai dengan kesiapan Pemerintah Indonesia dalam menyelenggarakan perlindungan terhadap buruh migran tersebut. Selain disebabkan oleh konflik kewenangan antar lembaga penyelenggara, juga disebabkan oleh kapasitas SDM calon buruh migran ABK itu sendiri. Hal ini diperparah dengan lemahnya aturan perlindungan pekerja terhadap buruh migran oleh negara bendera kapal.
Rekomendasi Model Bisnis Bank Perekonomian Rakyat Syariah Melalui Pendekatan Blue Ocean Strategy
Authors:   Pusat Studi Ekonomi dan Bisnis Islam (CIBEST), IPB University, Dwi Utami Anisa ,   Departemen Agribisnis, Fakultas Ekonomi dan Manajemen, IPB University, M Baga Lukman ,   Pusat Studi Ekonomi dan Bisnis Islam (CIBEST), IPB University,   Departemen Agribisnis, Fakultas Ekonomi dan Manajemen, IPB University, Yanuar Rahmat ,   Pusat Studi Ekonomi dan Bisnis Islam (CIBEST), IPB University,   Departemen Agribisnis, Fakultas Ekonomi dan Manajemen, IPB University, Nur Syamsiah Tita ,   Pusat Studi Ekonomi dan Bisnis Islam (CIBEST), IPB University,   Departemen Ekonomi Syariah, Fakultas Ekonomi dan Manajemen, IPB University, Busaid Busaid ,   Pusat Studi Ekonomi dan Bisnis Islam (CIBEST), IPB University, Mahanani Yekti ,   Pusat Studi Ekonomi dan Bisnis Islam (CIBEST), IPB University
Published: April 2023

Perubahan lingkungan bisnis yang terjadi, menuntut BPRS untuk dapat menyesuaikan strategi dan model bisnisnya. Potensi yang dimiliki oleh BPRS baik dari sisi internal dan dan eksternal serta dengan adanya peluang pasar UMKM yang begitu besar menuntut BPRS untuk dapat menyesuaikan kembali model bisnis yang akan dijalankan. Pendekatan Business Model Canvas (BMC) yang dikombinasikan dengan Blue Ocean Strategy (BOS) dalam model bisnis BPRS diharapkan dapat menciptakan inovasi nilai yang fokus pada pasar-pasar spesifik dalam menjalankan bisnisnya. Hal ini diharapkan akan dapat meningkatkan kemampuan BPRS untuk menjangkau pasar yang lebih dalam.
Strategi Kerjasama Pemerintah Daerah Sebagai Upaya untuk Percepatan Penurunan Stunting di Maluku dan Papua
Authors:   Departemen Gizi Masyarakat Fakultas Ekologi Manusia, Institut Pertanian Bogor, Briawan Dodik , Khomsan Ali ,   Departemen Gizi Masyarakat Fakultas Ekologi Manusia, Institut Pertanian Bogor, Oklita Anggiruling Dwikani ,   rogram Studi Gizi, Sekolah Tinggi Ilmu Kesehatan Bogor Husada
Published: April 2023

Stunting (pendek) adalah masalah gizi yang sampai saat ini belum terselesaikan. Data survey nasional menunjukkan prevalensi stunting sebesar 24,4 % (SSGI tahun 2021). Khusus di Provinsi Maluku prevalensi tersebut sebesar 28,70%, Maluku Utara 27,5%, Provinsi Papua 29,5% dan Papua Barat 26,2%. Adanya kesenjangan dari segi SDM dan data menjadi faktor terhambatnya program pemerintah dalam upaya menurunkan angka stunting di 4 Provinsi tersebut. Policy brief ini disusun untuk memberikan informasi tentang permasalahan dan strategi dalam program percepatan penurunan stunting yang yang terkait dengan kesenjangan regulasi, efektivitas program, ketersediaan SDM dan keterbatasan data pendukung.
Validitas Pembelajaran Model Kooperatif Tipe Group Investigation Untuk Meningkatkan Kemampuan Berpikir Kritis Fisika Peserta Didik Kelas XI
Authors: Lestari Elsi , 'Ardhuha Jannatin , Verawati Ni Nyoman Sri Putu , Susilawati Susilawati
Published: April 2023

Penelitian ini bertujuan untuk mengembangkan perangkat pembelajaran model kooperatif tipe group investigation  yang  layak  untuk meningkatkan kemampuan berpikir kritis fisika peserta didik kelas XI. Jenis penelitian yaitu Research and Development dengan desain penelitian yang digunakan adalah model 4D oleh Thiagarajan yang teridiri dari define, design, develop dan disseminate. Produk yang dikembangkan berupa silabus, rencana pelaksanaan pembelajaran (RPP), bahan ajar, lembar kerja peserta didik (LKPD) dan instrumen tes kemampuan berpikir kritis.  Penelitian ini dilakukan pada peserta didik kelas XI MIPA semester ganjil tahun ajaran 2022/2023 di SMAN 1 Sukamulia Lombok Timur dengan materi fluida dinamis. Pengambilan data penelitian menggunakan lembar validasi yang dinilai oleh 6 validator yang terdiri dari validator ahli yaitu 3 orang dosen pendidikan fisika dan validator praktisi yaitu 3 orang guru fisika. Data penelitian berupa data kuantitaif didapatkan dari lembar validasi, sedangkan data kualitatif didapatkan dari saran atau masukan yang digunakan sebagai acuan dalam memperbaiki perangkat pembelajaran. Data hasil validitas menunjukkan perangkat pembelajaran layak dengan kategori sangat valid dengan nilai rata-rata 86,12% dan reliabel dengan nilai persentase 94,22%. Berdasarkan hasil yang didapatkan maka dapat disimpulkan bahwa perangkat pembelajaran model kooperatif tipe group investigation yang dikembangkan layak untuk meningkatkan kemampuan berpikir kritis fisika peserta didik kelas XI.
Implementasi Program Sabtu Budaya Sebagai Penguatan Civic Disposition di SMP Negeri 15 Mataram
Authors: Nurmayanti Ayu , Ismail M. , Sawaludin Sawaludin , Yuliatin Yuliatin
Published: April 2023

Program Sabtu Budaya adalah kegiatan kokurikuler yang dilaksanakan sebagai bentuk pembelajaran berbasis budaya di sekolah. Tujuan penelitian ini untuk mengetahui proses implementasi program Sabtu Budaya sebagai penguatan Civic Disposition dan untuk mengetahui faktor pendukung dan penghambat implementasi program Sabtu Budaya sebagai penguatan Civic Disposition di SMP Negeri 15 Mataram. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian studi kasus. Teknik pengumpulan data menggunakan teknik observasi, wawancara dan dokumentasi. Berdasarkan data yang sudah di telah di ambil menunjukan bahwa bentuk implementasi program Sabtu Budaya sebagai penguatan Civic Disposition di SMP Negeri 15 Mataram yaitu : 1) Menanyikan lagu daerah, 2) Tata cara berbusana adat sasak, 3) Permainan musik daerah, 4) Tata cara membuat makanan khas sasak, 5) Tarian Massal, 6) Pameran karya siswa. Faktor pendukung implementasi program Sabtu Budaya antara lain yaitu, kompetensi guru  sebagai pelaksanan program Sabtu Budaya, dukungan dan kerjasama guru dan staff, ketersediaan tempat pelaksanaan, dan ketersediaan fasilitas program Sabtu Budaya.Hambatan yang diterima yaitu tidak adanya panduan program Sabtu Budaya, tidak adanya tim khusus program Sabtu Budaya, kurangnya partisipasi siswa dan orang tua dalam program Sabtu Budaya.
O CUIDADO NA DOENÇA DE PARKINSON: UM ESTUDO A PARTIR DO SERVIÇO SOCIAL COM AS CUIDADORAS DE HOMENS DO PROJETO PARKINSON DO NÚCLEO DE ATENÇÃO AO IDOSO DA UNIVERSIDADE DO ESTADO DO PARÁ
Authors: Silva Elane do Socorro Oliveira da , Cota Karen Regina Ferreira , Silva Rosiane Silva da
Published: April 2023

O Parkinson é uma das doenças crônico degenerativas mais
prevalentes. A Doença de Parkinson (DP) é considerada um distúrbio
do movimento mais frequente, e possui quatro componentes básicos
(rigidez muscular, bradicinesia39, tremor e instabilidade postural). O
chamado movimento de “contar moedas”, é o movimento mais típico
nas mãos do parkinsoniano (REIS et al., 2019)
ANÁLISE E CORRELAÇÃO DOS MÉTODOS DE DIAGNÓSTICO DO APARELHO AURICULAR COM OS SINTOMAS OSTEOMUSCULARES DO CORPO
Authors: Mineshita Larissa Natsumi Hosoda , Nobre Angélica Homobono , Dias George Alberto da Silva , Pessoa Lauro Lincoln da Silva
Published: April 2023

A auriculoterapia chinesa é uma das práticas da Medicina
Tradicional Chinesa (MTC), considerada segura, eficaz e com grande
aceitabilidade, uma vez que é reconhecida por seus efeitos benéficos
em distúrbios psíquicos, físicos e mentais, sendo as desordens corporais tratadas por meio de pontos específicos do pavilhão auricular (KUREBAYASHI; SILVA, 2015).
ENSINO EM SAÚDE POR MEIO DE PROJETOS: CRIAÇÃO DE UMA MÍDIA AUDIOVISUAL COMO RECURSO DE ENSINO TECNOLÓGICO EM UM CURSO DE FISIOTERAPIA
Authors: Alves Júlio Cesar da Rocha , Falcão Luiz Fábio Magno , Normando Valéria Marques Ferreira
Published: April 2023

A incorporação de novas tecnologias na área da saúde depende
dos avanços científicos e tecnológicos, o que requer das instituições de
ensino e pesquisa, sobretudo aquelas fomentadas por recursos públicos,
a proposição de ideias inovadoras em processos e produtos
(OLIVEIRA; RODAS, 2017; SANTOS; GOLDSTEIN; RABELLO,
2016).
O PACIENTE COM VENTRÍCULO DIREITO SISTÊMICO
Authors:   Unidade de Cardiopatias Congênitas no Adulto, Amaral Fernando ,   Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto
Published: April 2023

Pacientes adultos com ventrículo direito sistêmico (VDS) são portadores de cardiopatias congênitas (CC) complexas, mais comumente a transposição dos grandes vasos (TGA) cirurgicamente corrigida no plano atrial e a transposição dos grandes vasos congenitamente corrigida (TGACC). Situações mais raras, como a dupla via de entrada do ventrículo direito e a síndrome da hipoplasia do ventrículo esquerdo, na qual o ventrículo direito se torna sistêmico após cirurgia, podem ser também encontradas. Recomenda-se que esses pacientes sejam acompanhados em centro terciário com estrutura adequada para o tratamento percutâneo e cirúrgico das complicações. O VDS tem características próprias e variáveis com tendência à disfunção progressiva, sendo necessária monitorização periódica pela ecocardiografia e ressonância magnética. A farmacoterapia é considerada empírica, porém justificáveis ten-tativas estão relatadas. As arritmias, frequentemente complexas, devem ser proativamente investigadas, particularmente a disfunção do nó sinusal na TGA e o bloqueio atrioventricular na TGACC, podendo ser necessário o desfibrilador implantável. Pacientes em classe funcional III/IV e disfunção ventricular podem necessitar de ressincronização cardíaca (RC). Na falência cardíaca sem resposta ao tratamento clínico e à RC, os pacientes devem ser encaminhados para possível suporte circulatório mecânico ou transplante cardíaco. Apesar da sobrevida a longo prazo ser eventualmente possível, particularmente na TGACC, orientação ambulatorial cuidadosa é necessária. Frequentemente bem sucedida, a gestação deve ser contraindicada nas pacientes sintomáticas com disfunção do VDS, priorizando-se a anticoncepção.
FORAME OVAL PÉRVIO
Authors:   Instituto do Coração (InCor). Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), Vitoreti Martins Ana Vitoria , Thomaz Ana Maria ,   Instituto do Coração (InCor). Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), Zorzanelli Leína ,   Instituto do Coração (InCor). Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP)
Published: April 2023

O forame oval patente (FOP) está presente em até 30% dos adultos e tem se mostrado altamente prevalente em pacientes diagnosticados com acidente vascular cerebral isquêmico (AVCI) de causa desconhecida, também chamado de AVCI criptogênico. Supõe-se que a principal causa desse evento seja uma embolia paradoxal facilitada pela presença do FOP, especialmente em pacientes mais jovens e com poucos fatores de risco, sugerindo um papel causal para o FOP (“AVC relacionado ao FOP”). As recomendações de manejo do FOP no AVCI criptogênico estão evoluindo rapidamente. Os dados se expandiram recentemente após quatro grandes estudos demonstrarem a superioridade do fechamento percutâneo do FOP quando comparado ao tratamento medicamentoso na prevenção da recorrência do AVCI criptogênico. O fechamento do FOP, visando a profilaxia secundária após um AVCI, deve ser considerado em pacientes com idade ≤60 anos após avaliação minuciosa e discussão sobre benefícios e riscos potenciais do procedimento. O acúmulo crescente de evidências embasa o fechamento percutâneo do FOP com dispositivos de última geração, levando em consideração prognóstico, qualidade de vida e benefício econômico, quando bem indicado para grupo correto de pacientes. O desenvolvimento do escore RoPE (Risk of Paradoxical Embolism) auxiliou na identificação de pacientes com AVCI criptogênico e FOP, potenciais candidatos ao fechamento do FOP. A literatura disponível raramente inclui pacientes com ataque isquêmico transitório (AIT), idade maior que 60 anos e etiologias concorrentes como fibrilação atrial, portanto os resultados não podem ser generalizados para toda a população. Ainda não há consenso sobre marcadores biológicos disponíveis ou fatores de risco para predizer recorrência do AVCI relacionado ao FOP. Uma abordagem multidisciplinar com par-ticipação de cardiologista clínico, neurologista, hematologista e cardiologista intervencionista pode oferecer um melhor plano terapêutico, individualizado para cada paciente levando em consideração dados disponíveis, além de informações médicas, sociais e ocupacionais.
HIPERTENSÃO PULMONAR NO ADULTO COM CARDIOPATIA CONGÊNITA: TRATAMENTO ATUAL
Authors:   Instituto do Coração ( Incor) do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo ( HC FMUSP), Vitoreti Martins Ana Vitoria , Zorzanelli Leina ,   Instituto do Coração ( Incor) do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo ( HC FMUSP), Thomaz Ana Maria ,   Instituto do Coração ( Incor) do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo ( HC FMUSP)
Published: April 2023

A hipertensão pulmonar no paciente adulto com cardiopatia congênita é uma complica-ção de amplo espectro clínico. Em linhas gerais, o manejo desses pacientes envolve uma série de fatores, incluindo abordagem não medicamentosa e abordagem medicamentosa. A abordagem não medicamentosa é fundamental e inclui medidas como educação do paciente, orientações contraceptivas, cuidados dentários, vacinação, acompanhamento psicossocial. O tratamento medicamentoso, por sua vez, vem apresentando ganhos substanciais ao longo dos últimos anos, com maior número de medicações disponíveis. As medicações vasodilatadoras pulmonares apresentam diferentes mecanismos de ação e diferentes perfis farmacológicos. Os tipos de vasodilatadores pulmonares disponíveis são: inibidores de fosfodiesterase 5, antagonistas do receptor de endotelina, análogos da prostaciclina, agonistas seletivos dos receptores da prostaciclina. Em relação ao trata-mento cirúrgico, o paciente deverá ser avaliado quanto à correção de shunts e indicação de transplante. Outra parte importante do manejo dessa patologia inclui a abordagem de fatores descompensadores, como fenômenos trombóticos, arritmias, infecções e insuficiência cardíaca.
INTERVENÇÕES PERCUTÂNEAS NOS ADULTOS COM CARDIOPATIAS CONGÊNITAS
Authors:   Instituto Dante Pazzanese de Cardiologia, Cardoso Pedra Carlos Augusto , Silva Ribeiro Marcelo ,   Instituto Dante Pazzanese de Cardiologia, Nieckel Costa Rodrigo ,   Instituto Dante Pazzanese de Cardiologia, Lago Kreuzig Daniela ,   Instituto Dante Pazzanese de Cardiologia, Fontes Pedra Simone ,   Instituto Dante Pazzanese de Cardiologia
Published: April 2023

Nas últimas décadas, as intervenções percutâneas assumiram um papel central no manejo de fetos, neonatos, crianças e adolescentes com cardiopatias congênitas, contribuindo para um aumento significativo da sobrevida desses pacientes. Isso resultou em um incremento exponencial de adultos portadores de cardiopatias congênitas, já superando em números àqueles da faixa etária pediátrica em todo o mundo. Pacientes no pós-operatório da cirurgia de Fontan e Tetralogia de Fallot, por exemplo, apresen-tam anormalidades e complicações tardias que podem ser abordadas no laboratório de cateterismo. Por outro lado, ainda vemos adultos com cardiopatias congênitas nativas não tratadas, especialmente em países em desenvolvimento onde o acesso a centros de referência é mais limitado. Neste artigo de revisão, será abordado o papel das intervenções percutâneas, muitas vezes usando técnicas complexas, no manejo desses pacientes. As condutas sugeridas neste artigo são resultado das mais recentes diretrizes publicadas e vão de encontro à experiência dos autores. Revisões recentes sobre o papel da intervenção nessa população também embasam essa abordagem. Foram selecionados os quatro grupos principais de atuação da intervenção transcateter nas cardiopatias congênitas para discussão aprofundada do tema, com o objetivo de trazer luz a essa importante alternativa do arsenal terapêutico à disposição do cardiologista que se depara com esses pacientes. Quando devidamente indicados, ótimos desfechos podem ser observados, empregando-se técnicas menos invasivas com menor morbidade e mais rápida recuperação.
Multiplex PCR assay for detection of Helicobacter pylori isolated from Iraqi dyspeptic patients
Authors: Kalaf Elham A.
Published: April 2023

Helicobacter pylori (H. pylori) is one of the most common infections worldwide and is associated with gastric disorders. H. pylori is genetically unstable and this reflected on its virulence factors and type of diseases. Cytotoxin associated gene A (CagA) product is a major virulence factor is thought to be associated with gastric disease. It is injected into epithelial cells, undergoes phosphorylation by host cell kinases, and perturbs host signaling pathways. In the present study, we used multiplex PCR assay for rapid detection of H. pylori infection and for the determination of CagA genotypes directly from gastric biopsy specimens. Gastric biopsies were collected from 210 patients with dyspeptic symptoms. Genotypic analysis of H. pylori genes was found 91.17% for 16S rRNA, 87.25% for flagellin A, 89.21% for glmM (ureC) and cagA gene was detected in (39.21%) 40 biopsy specimens. Our study indicated that ureC (glmM) gene PCR is the most specific for the detection of H. pylori in gastric biopsy specimens compared with16S rRNA gene. There were significant differences (P ≤ 0.01) in cagA positive rate, among different diseases.
Apoptotic Activity of methionine γ- lyase on several cancer cell lines
Authors: Odaa Nisreen H.
Published: April 2023

The apoptotic activity of methionine γ- lyase from Pseudomonas putida on cancer cell lines was indicated by measuring the concentration of cytochrome c in the supernatants of cell lines. The result revealed high concentration of cytochrome c in the supernatants of cancer cell lines (RD, AMGM and AMN3) respectively while the concentration of anti-apoptotic protein (Bcl-2) was very low.
COMPETITIVENESS OF AGRICULTURAL ENTERPRISES IN MARKET CONDITIONS AND WAYS OF ITS INCREASE
Authors: Tomashuk Inna
Published: April 2023

The purpose of the article is to study the modern trends in the development of agricultural enterprises and the factors influencing the increase of competitiveness of their activities in modern economic conditions. Methodology. One of the main elements of the methodology of conducting researches on competitiveness of business entities are evaluation methods. The work also used such research methods as: comparison, balance, graphic, economic-mathematical and other methods of economic reasoning, as well as systematization and generalization (to develop recommendations and proposals for the formation of an organizational and economic mechanism in the conditions of a turbulent environment), economic-statistical, structural-logical and analytical (to develop methods and indicators for ensuring the competitiveness of enterprises), graphic (to present the dynamics of indicators and also for the best perception of information on sustainable development). The results of the work show that the paradigm of competitiveness management of enterprises is currently being formed around the issue of competition for the future, the impact of globalization trends and ensuring successful functioning in the strategic perspective in accordance with the established goals, which requires the formation of new strategic thinking in the management system at the macro and micro levels. Practical implications. Development of any strategy requires justification of goals and objectives, application of acquired knowledge, skills and abilities in making strategic management decisions. Therefore, the formation of a strategy for the development of an agricultural enterprise should begin with an analysis of the external and internal environment. Determining the strategic prospects for the development of an agricultural enterprise should be based on an analysis of changes occurring in the external environment, an assessment of the strategic positions of the enterprise, its strengths and weaknesses. Value / originality. Based on the specifics of their operating environment, it is advisable for agricultural enterprises to focus on achieving competitive advantages associated with lower costs. Such a competitive strategy includes cost optimization at the level necessary to fully meet production needs and continuous cost control. In addition, production cooperation plays an important role in managing the competitiveness of agricultural enterprises.
The Lived Experience of Being an Adoptee
Authors: Galea Michael , Cassa Cristina Said
Published: April 2023

Adoption can initiate many sentiments. Notable differences between adopted and nonadopted children are clearly indicated in research. Because limited research looks at the gradual development of the adoptee, this research looked at the lived experiences of Maltese adoptees and their coping mechanisms.

Following Smith and Osborn (2015) guide on interpretative phenomenological approach, six participants shared their experiences in semi-structured interviews conducted remotely.

Four superordinate themes and ten subordinate themes emerged from the data analysis.

Findings showed unique ways by adoptees to accept the often challenging reality of the adoption process. Resilience was clearly what led adoptees moving on with life. Society and related bodies are therefore called to avail professional services to assist adoptees in their coping of a painful past.
Indications and complications of double J Stents: A comprehensive review
Authors: R Ouaddane Alami  , N Alaoui Mhammedi  , Z.BA  , M.Ahsaini  , S Mellas  , J El Ammari  , MF Tazi  , MJ El Fassi  , MH Farih
Published: April 2023

Objectives: To describe the different complications of the JJ catheter, and to determine the association between the duration of implantation and the occurrence of complications. Patients and methods: Retrospective descriptive study of 37 cases of patients with complicated ureteral stents collected from January 2016 to April 2017; Results: The average duration of implantation was 7months and 10d, 37 patients (mean age 41. 5) were included: 26 men and 11 women, the most frequent complication was encrusted JJ (70.2%), followed by urinary tract infection (21.6%), an endo-urological treatment was chosen in first intention and consisted in the extraction of the double J catheter under cystoscopy (with recourse to an endolithotomy in case of encrusted JJ), allowing to obtain a very good results.
Understanding testicular malakoplakia: A rare inflammatory condition and its clinical implications case report
Authors: R Ouaddane Alami  , N Alaoui Mhammedi  , Z Ba  , M. Ahsaini  , S Mellas  , JEl Ammari  , MF Tazi  , MJ El Fassi  , MH Farih
Published: April 2023

Genitourinary malakoplakia (GUM) is a rare and chronic form of bacterial soft tissue infection, which primarily affects the genitals and urinary organs. the diagnosis is histological. Symptoms may include itching, pain during sex, bleeding, abdominal pain and burning during urination. Although treatment usually includes antibiotics, corticosteroids or anti-inflammatory drugs, and a variety of other medications and procedures may be needed to treat the symptoms. In some cases, surgery is also indicated.
Spontaneous rupture of the ureter in a tetraplegic patient: An exceptional case report
Authors: R Ouaddane Alami  , Z Ba  , N Alaoui Mhammedi  , Z Ba  , M Ahsaini  , S Mellas  , J El Ammari  , MF Tazi  , MJ El Fassi  , MH Farih
Published: April 2023

Spontaneous rupture of the ureter is very rare condition, and usually results from an obstruction of the urinary tract due to a stone. Few cases of spontaneous rupture are described in the literature, often considered theoretical because of the absence of an obvious etiology, as was the case of our patient where no cause was found, which makes the particularity of this clinical case.
Penyuluhan PHBS Dalam Mewujudkan Masyarakat Dusun Talang Parit Peduli Akan Kesehatan
Authors: Permatasari Jelly , Gusnawangti Gusnawangti , Safitri Dika Febrina , Luthfia Fildzah , Orlanda Devi , Ariani Marta , Sholeha Maratus , Amelia Putri , Fitriah Fitriah
Published: April 2023

Perilaku Hidup bersih dan sehat (PHBS) merupakan langkah yang harus dilakukan untuk mencapai derajat kesehatan yang optimal bagi setiap orang. Hidup sehat merupakan hal yang seharusnya diterapkan oleh setiap orang, mengingat manfaat yang ditimbulkan akan sangat banyak, mulai dari konsentrasi kerja, kesehatan dan kecerdasan anak sampai dengan keharmonisan keluarga. Kondisi sehat tidak serta merta terjadi, tetapi harus senantiasa diupayakan dari yang tidak sehat menjadi hidup yang sehat serta menciptakan lingkungan yang sehat.Rumah tangga berperilaku hidup bersih dan sehat dapat terwujud apabila ada keinginan, kemauan dan kemampuan para pengambil keputusan dan lintas sector terkait agar Perilaku hidup bersih dan sehat (PHBS).Perilaku merupakan wujud tindakan seseorang berdasarkan pemahaman dan kemauan terhadap sesuatu yang dihadapi. Sedangkan lingkungan merupakan wahana dimana mahkluk dapat bertahan dan berkembang biak. Upaya ini harus dimulai dari menanamkan pola pikir sehat kepada masyarakat yang harus dimulai dan diusahakn oleh diri sendiri. Upaya ini adalah untuk mewujudkan derajat kesehatan masyarakat setinggi-tingginya sebagai satu investasi bagi pembangunan sumber daya manusia yang produktif.Sementara itu, masyarakat Talang Parit kurang kesadaran akan kesehatan dan pola hidup bersih dan sehat. Untuk itu pemberian penyuluhan terkait Perilaku Hidup bersih dan Sehat diharapkan dapat menjadi upaya menyadarkan masyarakat Talang Parit akan pentingnya melakukan upaya Perilaku Hidup bersih sehat dalam merealisasikannya sehingga bisa terwujud masyarakat yang peduli sehat
Izazovi poreznog nadzora između pravila i prakse u Hrvatskoj i Sloveniji
Authors: Žunić Kovačević Nataša , Kovač Polonca
Published: April 2023

U radu se daje komparativni prikaz poreznog nadzora u Hrvatskoj i Sloveniji te se ukazuje na nužnost razlikovanja pojma porezni nadzor od nadzora u poreznom pravu. Pored poreznog nadzora pojavljuju se i druge vrste ili oblici nadzora u oporezivanju. Položaj poreznog obveznika, prava i obveze sudionika u poreznom nadzoru bitno su drukčija u odnosu na druge vrste nadzora u poreznom pravu. Jedan je od ključnih elemenata u prepoznavanju i rješavanju izazova poreznog nadzora u Hrvatskoj i Sloveniji razumijevanje koje vrste nadzora porezni propisi definiraju, budući da pozicije poreznog tijela i poreznog obveznika nisu iste kada su u pitanju različiti kontrolni postupci. Zbog nejasnoća u praksi upozorava se na potrebu sustavnoga pristupa te jasnog razlikovanja vrsta nadzora u cilju ostvarivanja pravne sigurnosti te zakonitosti u oporezivanju.
Nacrt prijedloga Zakona o izvanparničnom postupku – neka izabrana pitanja
Authors: Dika Mihajlo , Maganić Aleksandra
Published: April 2023

Izgledno je da će desetljećima očekivana reforma hrvatskog izvanparničnog prava konačno rezultirati zakonskim tekstom. Naime, na stranicama e-savjetovanje objavljen je Nacrt prijedloga Zakona o izvanparničnom postupku, kojim se prvi put u Hrvatskoj samostalno uređuje izvanparnični postupak. Stoga je svrha ovoga rada prezentirati neka izabrana pitanja općeg i posebnog dijela Nacrta. U dijelu koji se odnosi na opći dio Nacrta prikazat će se pitanje sadržaja i područja njegove primjene, pitanje supsidijarne (odgovarajuće) primjene odredaba zakona koji uređuju parnični postupak te pitanje statusa javnoga bilježnika u izvanparničnom postupku. Uz to prezentirat će se i (krnji) sadržaj posebnog dijela, usporediti ga sa sadržajem posebnih dijelova odabranih komparativnih sustava te analizirati pravne posljedice koje će imati izostalo uređenje stvarnopravnih izvanparničnih postupaka – uređenja međa, razvrgnuća suvlasništva i nužnih prolaza.
Community SARS-CoV-2 Dynamics and Cycle Threshold Use to Enhance Public Health Surveillance in the Dominican Republic
Authors: Tapia Leandro , Paulino Amy , Suero Claudia , Delgadillo Miguel , Medina Claudia , Maletta Leeany , Trochez Stephanie , Castillo Jason A. , Duque Canaán Paula M. , Vallejo Alejandro , Hidalgo Daniela , Del Orbe Diego , Cabrera Jhasmel , Campaña Jose , Sanchez Estefani , Paulino-Ramirez Robert
Published: April 2023

To propose appropriate containment measures and optimize surveillance strategies, it is of utmost importance to understand the dynamics of SARS-CoV-2 transmission within different age groups and its symptomatic and asymptomatic presentations. This study aimed to understand the cycle-threshold (Ct) of SARS-CoV-2 within individuals attending hospital-based facilities in the Dominican Republic. A total of 3,309 saliva samples were analysed from 14 provinces, which yielded a positivity rate of 18.01% (n=596) across 24 sites. Saliva specimens and levels of viral RNA were quantified by RT-qPCR. Overall mean Ct values were 29.3 cycles and significantly correlated with community positivity rate (r=-0.034, p=0.04). There was no significant difference in mean Ct values between studied age groups [F (19, 30) = 0.65, p = 0.5] and no significant correlation between mean Ct by age groups and community positivity. When comparing asymptomatic and symptomatic patients by age groups, the patients between 5 and 17 years old demonstrated a statistically significant mean difference in Ct values with 27.5 and 32.4 cycles, respectively (t (14) = -2.3, p = 0.03). Results identified in this study demonstrate how understanding community viral load is crucial for optimal SARS-CoV-2 surveillance and should be evaluated in the context of transmissibility dynamics.
Competitive Effects of Substitutions in the La1−xSrxMn0.9(MgyGez)0.1O3 + γ System
Authors: Badelin A. G. , Derzhavin I. M. , Karpasyuk V. K. , Estemirova S. Kh.
Published: April 2023

Structural, magnetic, and electrical characteristics of La1 − xSrxMn0.90(Mg0.5Ge0.5)0.10O3 + γ (0.15 < x < 0.30, γ = 0, γ > 0) and La0.91Sr0.09Mn0.90Mg0.10O3, La0.71Sr0.29Mn0.90Ge0.10O3 manganites are investigated and compared. A comparison of the properties of manganites with identical total concentrations of substituents for manganese and equivalent concentrations of Mn4+ and Mn3+ ions reveals several competing effects caused by Sr2+(4p6), Mg2+(2p6), Ge4+(3d10) ions and oxygen.
The excess risk of noise-induced hearing loss numerical assessment scale
Authors: Prokopenko Ludmila V. , Courierov Nicolay N. , Lagutina Alla V.
Published: April 2023

Relevance. In the new edition of the Labor Code (as amended on 02.25.2022), risk-oriented approaches to management in the field of labor protection are fixed, which necessitated the revision of regulatory and methodological documents, including in the field of occupational medicine based on the methodology for assessing occupational risk to workers' health.
The study aims to substantiate and develop a numerical scale for assessing the group attributive risk of hearing loss from exposure to industrial noise.
Materials and methods. The authors have carried out an expert-analytical study of materials on qualitative and quantitative a priori and a posteriori assessment of occupational risk.
Results. The scientists have confirmed the advantage of attributive risk over other indicators for assessing the risk of hearing loss from noise. The numerical scale of the assessment of the attributive risk of hearing loss in relation to the risk-oriented hygienic classification of working conditions and the assessment of the relationship of hearing impairment from noise with work, depending on the magnitude of the attributive risk and etiological proportion, is substantiated. We have justified the categorization of the attributive risk of hearing.
Limitations. Features of the model for assessing hearing loss due to noise exposure according to GOST R ISO 1999:2017.
Conclusion. The development of a quantitative scale for assessing the attributive risk of hearing loss not only harmonizes the hygienic assessment of the noise risk factor with international practice, but also contributes to the development of the methodology for assessing and managing occupational risk.
Keywords: risk assessment; quantitative assessment scale of the attributive risk of hearing loss from noise; categorization of occupational attributive risk; risk-oriented hygienic criteria and classification of working conditions; the rule of "equal energy"; connection of health disorders with work
Ethics. In preparing the article, the authors were guided by the Ethical principles of medical research set out in the Helsinki Declaration of the World Medical Association of the last revision.
Prediction of elevation points using three different heuristic regression techniques
Authors: DEMİR Vahdettin , DOĞU Ramazan
Published: April 2023

The aim of this study is to estimate the digital elevation model, which is the most important data of the projects and needed in the engineering project, using latitude and longitude information of the elevation points and three different heuristic regression techniques. As the study area, an area with mid-level elevations, located in the Marmara region, and covering a part of the intersection of Edirne, Kırklareli and Tekirdağ provinces was chosen. In the study, the estimations were investigated for three different sized areas, and these areas are square areas with the dimensions of 1x1 km, 10x10 km and 100x100 km, respectively. A total of 3500 elevation points were used in the study, and this number is constant in all areas, and 60% of these points were used in the testing phase and 40% in the training phase. The models used in the study are M5 model tree (M5-tree), multivariate adaptive regression curves (MARS) and Least Square Support Vector Regression (LSSVR). The results of the models were evaluated according to three different comparison criteria. These, coefficient of determination (R2), Mean Absolute Error (MAE) and Root Mean Square Error (RMSE) were used. When the modeling results are examined; M5-Tree regression method gave the best results (1), LSSVR method was better than MARS methods (2), The most successful input data was found in datasets using X and Y coordinates information, and the worst results were found in datasets using X coordinates (3). As the study area increased, the model performance did not improve (4). The least error was obtained in the modeling of 1x1 km area, and the highest R² was obtained from the modeling of 10x10 km area (5). It was concluded that the M5-tree method is a very successful method in elevation modeling.
Pelakor
Authors: M Gendis Ayu Wulan
Published: April 2023

Sebelum menjelaskan pandangan hadis tentang pelakor, perlu dijelaskan terlebih dahulu bahwa pelakor merupakan singkatan dari "perebut laki orang", yaitu seorang perempuan yang terlibat dalam hubungan dengan seorang pria yang sudah menikah dengan perempuan lain.Dalam pandangan hadis, pelakor dianggap sebagai tindakan yang sangat dilarang dan diharamkan oleh Allah SWT. Hal ini dapat dilihat dari beberapa hadis yang menjelaskan tentang larangan berselingkuh dan melakukan perbuatan zina.Salah satu hadis yang menjelaskan tentang larangan berselingkuh dan melakukan perbuatan zina adalah hadis yang diriwayatkan oleh Abu Hurairah RA, bahwa Rasulullah SAW bersabda, "Janganlah seorang laki-laki berselingkuh dengan seorang perempuan, dan janganlah seorang perempuan berselingkuh dengan seorang laki-laki. Dan janganlah kamu mendekati zina. Sesungguhnya zina adalah perbuatan yang keji dan jalan yang buruk." (HR. Bukhari)Dari hadis tersebut, dapat dipahami bahwa perbuatan berselingkuh atau melakukan zina merupakan perbuatan yang keji dan sangat diharamkan oleh Allah SWT. Oleh karena itu, perempuan yang menjadi pelakor dianggap melakukan perbuatan yang sangat salah dan melanggar aturan-aturan yang telah ditetapkan oleh Allah SWT.Secara umum, pandangan hadis tentang pelakor sangat jelas dan tegas, yaitu sebagai perbuatan yang sangat dilarang dan diharamkan oleh Allah SWT. Sebagai umat muslim, kita diharapkan untuk senantiasa menjauhi perbuatan zina dan selalu mengikuti aturan-aturan yang telah ditetapkan dalam agama Islami