bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of beta-glucan on the organism of broilers
Authors:   “All-Russian Research Veterinary Institute of Poultry Science” — Branch of FSC ARRTPI RAS (ARRVIPS), Ryabtsev P.S. , Nadein K.A. ,   “All-Russian Research Veterinary Institute of Poultry Science” — Branch of FSC ARRTPI RAS (ARRVIPS), Bartenev A.A. ,   “All-Russian Research Veterinary Institute of Poultry Science” — Branch of FSC ARRTPI RAS (ARRVIPS), Zaikin V.A. ,   “All-Russian Research Veterinary Institute of Poultry Science” — Branch of FSC ARRTPI RAS (ARRVIPS)
Published: November 2020

Our studies are devoted to the search for new drugs with antioxidant, antihypoxant, immunomodulatory effects in order to in-crease the productivity of poultry. Due to the fact that beta-glucan has not previously been studied on poultry, before determining the effective therapeutic range of its doses, it is necessary to study the effect of a conditionally therapeutic dose of the drug on the body. A conditionally therapeu-tic dose - hereinafter - means the average therapeutic dose of a drug offered by the manufacturers of the respective drugs, calcu-lated for humans (mammals).The main pur-pose is to study the effect of beta-glucan on meat productivity, morphological, biochemi-cal indices of blood. In the experiment we used clinically healthy young hens of meat breeds of three months of age of the “Cobb 500” cross. The broilers of the first group (n = 9) were not prescribed the drug, they served as controls; the second group (n = 9) were given beta-glucan at 10 mg/kg body weight, corresponding to 125 g/t of food, for 14 days. The use of beta-glucan was accom-panied by an increase in the average daily body weight, gain by 4,9%, slaughter yield by 1,5%, a significant increase in blood erythrocyte content by 32,6% on day 7, monocyte level by half, a decrease in total bilirubin by 21,0%, and a decrease in blood malonic dialdehyde by 10,8% on day 14. Cumulatively all data collected indicates positive effect of beta-glucan on meat productivity, morphological composition of blood broilers and metabolism in organism and prospects of its use in poultry industry.
Acute toxicity and comparative thera-peutic efficacy of levofloxacin in experimental colibacillosis of chickens
Authors:   Belgorod Branch of FGBNU FNTs VIEV RAN (Federal State Budget Scientific Institution “Federal Scientific Centre – All-Russia Scientific Research Institute of Experimental Veterinary Medicine after K.I. Skryabin and Ya.R. Kovalenko of Russian Academy of Sciences”), Mazur A.D. , Yurin D.V. ,   Belgorod Branch of FGBNU FNTs VIEV RAN (Federal State Budget Scientific Institution “Federal Scientific Centre – All-Russia Scientific Research Institute of Experimental Veterinary Medicine after K.I. Skryabin and Ya.R. Kovalenko of Russian Academy of Sciences”), Skvortsov V.N. ,   Belgorod Branch of FGBNU FNTs VIEV RAN (Federal State Budget Scientific Institution “Federal Scientific Centre – All-Russia Scientific Research Institute of Experimental Veterinary Medicine after K.I. Skryabin and Ya.R. Kovalenko of Russian Academy of Sciences”), Tarasova Yu.V. ,   Belgorod Branch of FGBNU FNTs VIEV RAN (Federal State Budget Scientific Institution “Federal Scientific Centre – All-Russia Scientific Research Institute of Experimental Veterinary Medicine after K.I. Skryabin and Ya.R. Kovalenko of Russian Academy of Sciences”)
Published: November 2020

Development and improvement of treatment modes for colibacillosis in chickens is very important as this disease is rather prev-alent in bird population. Fluoroquinolones are drugs that are very effective in treating bacterial infections, associated with Gram- negative microorganisms, in animals. The goal of the present research was to evaluate acute toxicity of Levofloxacin in chickens and to study its comparative therapeutic effi-cacy in experimental colibacillosis of chick-ens. For the experiment aimed at evaluating acute toxicity of Levofloxacin all the chick-ens were assigned to a total of 18 groups, 10 chickens were assigned to each group. The drug was administered by intraperitoneal injection at a dose of 100 to 950 mg/kg body weight. In our research median lethal dose (LD50) of Levofloxacin, in case of intraperi-toneal introduction to chickens, was as high as 470 mg/kg body weight (276.4–799 mg/kg body weight). For the experiment aimed at studying comparative therapeutic efficacy of Levofloxacin in experimental colibacillosis all the chickens were assigned to a total of 8 groups, 25 chickens were assigned to each group. In the course of the experiment every chicken was challenged with Escherichia coli, by intraperitoneal introduction of 150 million CFUs (E. coli had been cultured in suspension for 24 hours). Antimicrobial drugs (Levofloxacin, Enrofloxacin, Colistin, Ditrim, Doxycycline, Chloramphenicol) were first administered 24 hours before the challenge, at a concentration of 200 mg/L, via drinking water. The treatment continued 5 days. The chickens were monitored 3 weeks. The results of the experiments show the high therapeutic effect in cases of Levofloxacin (100%) and Enrofloxacin (92%). Administration of other antimicrobial drugs did not lead to the expected results. The survival rate was in the range 12 to 20%
Medical treatment of guttural pouch my-cosis in horses
Authors:   FGBU “SPbGAVM”, Karanina V.D.
Published: November 2020

Mycosis of the air-bearing SAC is an infectious chronic disease of horses, charac-terized by nasal discharge and bleeding, var-ious neuropathies; and the main danger of which is the possibility of lethal epistaxis. Fungi of the genus Aspergillus enter the cav-ity of the bags with inhaled air and settle on the mucosa, damaging the large arterial ves-sels (internal and external carotid arteries) and nerves (facial, lingopharyngeal, vagus and hypoglossal cranial nerves) running along its surface. The recommended treat-ment is surgery on the carotid arteries. How-ever, in a stable environment, conservative treatment is safer. This paper provides an overview of effective drug therapy regimens for mycosis of the equine air SAC. For successful elimination of the patho-gen, it is necessary to occlude the affected vessels to limit the nutrition of the fungus. However, such surgical techniques are ac-companied by a huge risk, require expensive supplies, a sterile operating room and a high-ly qualified veterinarian. The effectiveness of conservative treat-ment consists of two components: mechani-cal action on the fungus in order to separate it and antimycotic therapy, taking into ac-count the sensitivity of the species to the antibiotic. Daily flushing of the air bag with an endoscope at the site of the lesion can soften the diphtheria membrane, which will later allow it to be separated from the wall using biopsy forceps or a cytological brush. The relevance of the work is that it is easier and safer to carry out conservative treatment of mycosis of the air bag in sta-bles. The purpose of this work is to review effective treatment regimens for mycosis of the equine air SAC without surgical inter-vention. So, we can call the treatment regi-men Itraconazole priority, because this drug has been widely studied on horses and has a high activity to fungi of the genus Aspergil-lus.
ESTIMATION OF EFFICIENCY OF DISINFECTION OF SURFACES OF EQUIPMENT WITH “FUMIOD” DRUG IN ANIMAL AND PIG BREEDING SPACES DURING SANITARY BREAK
Authors:   St. Petersburg state university of veterinary medicine, Kuzmin V.A. , Fogel L.S. , Sukhinin A. , Makavchik S.A. , Orekhov D.A. , Smirnova L.I. ,   St. Petersburg state university of veterinary medicine
Published: November 2020

The purpose of the work is to evaluate the effectiveness of preventive disinfection of surfaces of technological equipment with fumigation aerosols of the “Fumiyod” drug in livestock and pig premises during the san-itary break. The work was carried out in livestock and pig farms of the Volosovsky district of the Leningrad region. Disinfection of technological equipment in experimental facilities for growing calves and piglets dur-ing the sanitary rupture (after the mechanical cleaning and washing of equipment with hot water + 600С) was carried out by fumigation aerosols of the “Fumiyod” using iodine blocks by sublimation for 3 hours after expo-sure. Control was provided by similar facili-ties after mechanical cleaning and washing of equipment with hot water + 600С. Test objects – metal surfaces , concrete, tile, wood, rubber, metlakh tiles. The effective-ness of disinfection of surfaces of technolog-ical equipment was evaluated by test of the bacteria of the Escherichia coli group (BGEC) and staphylococcus. To isolate BGEC, KODA medium, or Endo agar, was used to indicate staphylococci — yolk-salt agar (6.5% NaCl). In an experiment in live-stock and pig breeding facilities, for the con-trol of the quality of disinfection for the iso-lation of BGEC, the “Fumiyod” effective disinfection of smooth surfaces at a concen-tration of 0.10 g / m3 for 1 h, rough surfac-es, respectively, 0.20 g / m3 for 1 hour for the isolation of staphylococci, respectively, in a concentration of 0.1-0.20 g / m3 of smooth and rough surfaces at an exposure of 3 hours were carried out. For the control (after washing the equipment with hot water and without disinfection) in washes from smooth and rough surfaces of equipment in pig breeding and livestock buildings BGEC were allocated in 70%; staphylococci, re-spectively, in 100% and 95% of the samples.
EXPERIENCE OF THE ORGANIZA-TION OF HORSE FEEDING WITH DYSFAGIA CAUSED BY A MYCOSIS OF THE AIRBAG SAC
Authors:   FGBOU VO SPbGUVM, Sharaskina O.G. , Bgantseva Yu.S. ,   veterinary clinic «Forsyd»
Published: November 2020

Organization of feeding sick horses play an important role in the treatment and recov-ery of the animal after the disease. In the case of dysphagia, the use of forced nutrition through a nasogastric tube is required, which makes special demands on the feed used and the form of their supply. The main objective of the study was to analyze the results of the organization of feeding of a horse with dys-phagia caused by mycosis of the air sac with damaged cranial nerves in a specific clinical case and assess the effectiveness of the feed-ing methods and techniques for subsequent use in veterinary practice. In the process of treatment, various methods of preparation and administration of feed and water were used. The most effective method at the be-ginning of treatment (2-3 weeks) was completely enteral feed administration. For the preparation of a mixture for enteral admin-istration, granular compound feeds are well suited that are adopted to the needs of the horse. As the function of swallowing is re-stored, it is possible to transfer to mush, which include concentrates and roughages. The introduction of roughage in its natural form is not advisable until the swallowing function is fully restored, due to the risk of aspiration pneumonia as hay particles can be thrown into the trachea. During the peri-od of treatment and long recovery, the horse may well manage with a minimum amount of dry matter in the diet (up to 1.5% BW), with sufficient intake of energy and protein. In determining the minimum nutritional needs of the horse, one can focus on the feeding standards of non-working horses with minimal physical activity, proposed by the NRC.
Nuclei preparation from human lung using douncing forsnRNA-seq v1
Authors: for Epigenomics UCSD Center
Published: November 2020

Protocol describing nuclei isolation from frozen tissue including lung using douncing for droplet-based single nucleus RNA-seq.
Functional outcome of Total Knee replacement using traditional Patelloplasty
Authors:   Assistant Professor, Department of Orthopedics, Velammal Medical College, Madurai, Tamil Nadu, India, Subramanian Dr. Muthukumar , Ram Dr. Ganesan G. ,   Professor, Department of Orthopedics, Velammal Medical College, Madurai, Tamil Nadu, India
Published: November 2020

Introduction: To evaluate the function of Patella following Patelloplasty in Total Knee Replacementusing the Hospital for Special Surgery Patella score. Materials and methods: This is a prospectivestudy done on patients who have undergone Total Knee Replacement from March 2018 to March2019. The study was done in Sri Ramachandra Medical College, Chennai, and Velammal MedicalCollege, Madurai. Result: In the present study Pre-op Knee, Scoring System scores were 40.92 andFunctional Scores were 42.87. Postoperatively Scores increased to 87.66 and 88.24 respectively.Patella Score is 86.29. No patient had anterior knee pain and functional limitation at the end of oneyear. The fundamental basis of retaining the patella was that the autogenous patella may bettermeet the physiological and anatomical requirements and avoid complications resulting from patellarresurfacing. Conclusion: In the present study, Patelloplasty has shown good functional results andan early pain-free range of movement.
Management of Old Neck Femur Fracture through Valgus Osteotomy and Pin Fixation
Authors:   Associate Professor, Department of Orthopedics, Sri Muthukumaran Medical College Chennai, Tamil Nadu, India, Rathod Dr. Chetan L , Chauhan Dr. Prakash ,   Associate Professor, Department of Orthopedics, Sri Muthukumaran Medical College Chennai, Tamil Nadu, India
Published: November 2020

Introduction: Valgus intertrochanteric osteotomy alters the biomechanical environment of thefracture site and restores limb length. Very few reports have dealt with the results of this procedureinternally fixed with a dynamic hip screw and double angle barrel plate. Hence, the prospectivestudy was performed at the institution level for the evaluation of results of valgus osteotomy andfixation of the femur neck fracture in young patients. Material and Methods: A total of 32 patientswere included in the study. There were 24 males and 8 females in the study. Before osteotomy, theaverage neck-shaft angle was 101° (80–120°), with an average limb shortening of 2.3cm (1.0–3.2cm). The greater trochanter was up riding in fourteen cases and needed skeletal traction beforesurgery. None of these had evidence of vascular necrosis on plain radiograph or MRI. The fractureswere treated with a dynamic hip screw and double angle barrel plate. The patients had a minimumfollow-up of 14months and a maximum of 42months. Results: In a total of 28 patients the excellentresults were obtained, however in 4 patients the poor result was due to cut – out of implants. Noneof the patients were lost on follow up, the fracture went on to achieve the satisfactory union afterthe minimum of 14 weeks follows up. The average preoperative neck-shaft angle of 101° (range 80–120°) increased to 134° (range 120–145°) after surgery. The average limb length discrepancypostoperatively was 2.3cm. Conclusion: From the study, it was concluded that valgus osteotomyand fixation with dynamic hip screw and 120° double angle barrel plate has a high success rate inyoung patients with neglected and ununited intracapsular fracture neck of the femur as far as theunion of fracture is concerned.
Management of Subtrochanteric Femur Fracture Using Proximal Femoral Nail
Authors:   Assistant Professor, Department of Orthopedics, Gujarat Adani Institute of Medical Science, Bhuj, Kutch, Gujarat, India, Gagal Dr. Navin , Hirani Dr. Anand ,   Assistant Professor, Department of Orthopedics, Gujarat Adani Institute of Medical Science, Bhuj, Kutch, Gujarat, India
Published: November 2020

Injuries to the femur, the longest bone in the body presents a challenging situationto the orthopedic surgeon. The proximal femoral intramedullary devices are useful for the treatmentof isolated pathological lesions in the subtrochanteric region. Biomechanically, the nail can withstandbetween 3to 5 times body weight. Hence the present study was planned to study the managementof these fractures with the proximal femoral nail. Materials and Methods: A total of 44 patientswith proximal femoral fractures of the subtrochanteric region admitted in the department wereincluded in the study. Patients age more than 25 years and diagnosed with subtrochanteric femurfracture were included in the study. Results: The age of the patients was more than 25 years. Therewere 34 males and 10 females included in the study. In the clinical evaluation as per the functionalGrading of the patient as per Kyle’s Criteria excellent and good results were considered satisfactory,whereas fair and poor results were considered unsatisfactory. In this series 92%, satisfactory resultswere obtained. Conclusion: Proximal femur nail (PFN) is an effective device in the management ofcomplex femoral fractures. The use of PFN in such fractures provides various advantages: Closedprocedure, Minimal soft tissue damage. It offers superior stabilization than other currently usedmethods of internal fixation. The use of PFN is technically demanding and needs expertise.Complications can be avoided by proper operative techniques. Early postoperative mobilization andphysiotherapy improve the results of PFN.
Potential clinical application of free-circulating DNA from blood in renal cancer
Authors: Yakubovich E. I. , Polishchuk A. G. , Evtushenko V. I.
Published: November 2020

Early diagnosis of renal cancer carcinoma is a key determinant of patient survival. The asymptomatic disease course and lack of reliable diagnostic markers lead to the fact that more than 30 % renal cancer cases discovered at an advanced stage, when the prognosis is poor because kidney tumors are resistant to standard chemotherapy and radiation. More than 30 % of renal cancer carcinoma recur or metastasize after surgical treatment. Despite the implementation of novel targeted drugs and immune point inhibitors, the 5-year survival rate for metastatic renal cancer carcinoma remains dismal. Unsatisfactory result of renal cancer treatment may be caused by high inter- and intra-tumor heterogeneity and tumor evolution during therapy, as well as the lack of predictive and on-treatment monitoring biomarkers. Liquid biopsy test that utilizes free-circulating DNA (cfDNA) in the blood of patients, opens up new opportunities for managing patients with renal cancer. The diagnostic and predictive potential of these minimally invasive biomarkers has been demonstrated for various types of cancer. The use of highly sensitive methods of cfDNA analysis may allow early cancer detection and prediction of postoperative disease recurrence before dinical and radiographic progression. Serial cfDNA samples, that were collected before and during course of treatment, can provide information about the dynamic mutational changes in the volume of the entire tumor and metastases in real time, and the emergence of drug resistance during treatment. This information may be promising toolfor optimizing patient-specific therapeutic strategies. This review is focusing on the potential clinical application of cfDNA from blood in renal cancer.
Advisory Council on combined immunochemotherapy for urothelial cancer
Authors: Editorial Article
Published: November 2020

Москва, 7 июля 2020 г.7 июля 2020 г. состоялось заседание консультационного совета, посвященное новому комбинированному иммунохимиотерапевтическому подходу в 1-й линии терапии пациентов с местнораспространенным или метастатическим уротелиальным раком.
Analysis of the reliability of smartphone-based goniometric applications
Authors: Sakata Mariana Saori Barboza , Wassmuth Talita , Ferreira Luiz Alfredo Braun , Rossi Luciano Pavan
Published: November 2020

Introdução: Os aplicativos goniométricos dos smartphones, são ferramentas acessíveis e portáteis que por meio de sensores internos, são capazes de realizar a medida do movimento articular. Contudo, todo instrumento utilizado na prática clínica deve ser válido e confiável, mantendo uma consistência em seus valores quando submetido às mesmas variáveis, circunstâncias e sujeitos. Objetivo: Analisar a mensuração angular de diferentes aplicativos goniométricos para smartphone, com diferentes tempos de uso e diferentes sistemas operacionais. Material e métodos: O presente estudo analisou a confiabilidade dos aplicativos de smartphones para goniometria, através da medida das angulações de um polígono projetado para o estudo, utilizando 100 smartphones, correlacionando diferentes aspectos e condições dos aparelhos. Resultados: De uma maneira geral não houve diferenças para quase todas as variáveis analisadas quando comparadas entre si, apenas houve diferença quando confrontados os dados coletados com os valores de referência. Conclusão: As variáveis analisadas nesse estudo não influenciaram nas leituras angulares, apresentando variações mínimas dos ângulos para todas as condições.
Effects of warm-up and stretching on the peak torque using electromyography - A randomized controlled clinical trial
Authors: De Camargo Cláudio Natanael , De Lima Juliane , Corrêa Marcelo Eduardo , Seninski Pedro Luiz Fiuza , Da Cruz Jéssica , Bini Viviane Eloisa , Ferreira Luiz Alfredo Braun , Pereira Wagner Menna
Published: November 2020

Introdução: A força muscular é definida como a capacidade de gerar rácios e torques máximos. Para que a musculatura atinja uma contração isométrica voluntária (CIVM), é necessária uma preparação da musculatura em movimento longitudinal, resultando em aumento da amplitude de movimento. O aquecimento é popularmente utilizado na prática de atividade física, física e física e física e muscular, levando o sistema cardiovascular a uma atividade motora mais eficaz. Para isso, é importante usar uma ferramenta de musculatura muscular para calcular a força da carga cardíaca. Objetivos: A força máxima (torque de torque) nos músculos posteriores da coxa e após um protocolo de aquecimento e alongamento.  Materiais e métodos: Vinte e três (23) isolados saudáveis, de ambos os sexos, sem histórico de lesão musculoesquelética na lista menor, os seis últimos meses, com idade entre 18 e 33 anos, em que foram realizadas através da eletromiografia, e distribuídos de forma aleatória em Grupo controle ( n = 10), Grupo aquecimento (n = 6) e Grupo alongamento (n = 7). O grupo controle, foi apenas avaliado. Os outros dois grupos foram por 10 semanas em um período de 5 semanas, após isso foram reavaliados. O grupo warman, exercendo as atividades em uma esteira durante 15 minutos / com a mesma velocidade devendo atingir 70% de sua capacidade máxima. O grupo alongamento construído durante o treino de estática dos músculos posteriores da coxa durante 20 minutos / intervenção. Resultados:Aumento da significância do pico de torque dos músculos posteriores da coxa, no grupo aquecimento (p = 0,04), e redução significativa no grupo alongamento (p = 0,01), no grupo controle não foi diferente. 0,08) Conclusão : Concluiu-se que o exercício foi eficaz na força do pico de torque e força da musculatura dos posteriores da coxa.
Relationship between anxiety and static and dynamic balance disorder in subjects with cerebrovascular accident (stroke) diagnosis
Authors: Ferreira Ana Paula Lemos , Barbosa Danillo
Published: November 2020

Background: Sensory systems are responsible for maintaining balance, being vision, vestibular and somatosensory, and all these systems suffer changes in patients with stroke sequelae and studies bet that anxiety is likely to influence the inability of the subject to use these systems, enhancing the postural imbalance in stroke patients. Objective: To analyze the interference of anxiety on the static and dynamic balance of patients diagnosed with stroke. Methods: Fifteen patients with stroke, aged 40 to 80 years, were assessed using the Hospital Anxiety and Depression Scale, Timed Up and Go test for dynamic balance and the Berg Scale for static balance. Data were tabulated in Excel and analyzed using SPSS - Statistical Package for Social Science (version 20.0). Results: Significant values were found for the correlation between anxiety and balance, in which the results analyzed showed that the balance of patients with stroke can be negatively exacerbated due to the anxiety that affects them. Conclusion: It can be concluded from these results that anxiety can alter the balance of these patients and thus, it is shown the importance of a multidisciplinary treatment from the first moment to leverage the treatment.
The use of myofascial release in the agility and power of healthy subjects: randomized controlled clinical study
Authors: Kulka Matheus Minosso , Pereira Wagner Menna , Pereira Nerison Lucas Costa , Correia Marcelo Eduardo , Pauli Paulo Henrique , Rossi Luciano Pavan , Ferreira Luiz Alfredo Braun , Dumont Arislander Jonathan Lopes
Published: November 2020

Introdução: A fáscia envolve todos os tecidos e órgãos do corpo, elemento importante na organização do movimento e transmissão de força entre segmentos corporais, qualquer disfunção ou alteração pode gerar hipomobilidade, alterando a biomecânica do movimento e restringir a força muscular. Diversas técnicas podem ser utilizadas para tratar tais disfunções, sendo a liberação miofascial uma das mais utilizadas para esse fim, tratando aderências de tecidos moles, diminuindo edema, inflamação, dor e sensibilidade, melhorando a força muscular. Dentre as técnicas de liberação miofascial existe a auto liberação miofascial, técnica que faz uso de um rolo de espuma, o foamroller, onde o indivíduo é quem realiza de forma ativa deslizamentos de um lado para o outro sobre o foamroller. Metodologia: Trata-se de um estudo clínico, controlado aleatorizado. Foram convocados 30 participantes saudáveis, os quais se submetidos há um período de treinamento por quatro semanas, com frequência de três dias por semana, divididos em três grupos distintos, sendo um o grupo alongamento ativo (AA) composto por 10 indivíduos, os quais realizaram alongamentos ativos dos músculos isquiotibiais e gastrocnêmios, grupo foamroller (FR) composto por 10 indivíduos que efetuaram a auto liberação miofascial através do foamroller e grupo controle (GP)formado por 10 indivíduos que não receberão nenhuma intervenção. Os participantes, inicialmente, foram submetidos a uma avaliação antropométrica (peso, estatura e índice de massa corporal), para agilidade realizou-se o Teste de Illinóis que apresenta uma alternativa interessante para avaliação e controle dessa capacidade motora, e Teste do Salto Vertical que tem sido destacado na literatura como principal método de medida de força explosiva de membros inferiores. Resultados: Foram recrutados trinta e cinco participantes, dos quais trinta obedeceram aos critérios de inclusão. No desenvolvimento do estudo, houve quatro desistências, totalizando uma amostra final de vinte e seis indivíduos, separados em três grupos. Grupo alongamento (GA), grupo foamroller (GFR) e grupo controle (GC). Após 4 semanas de intervenção, não foram observados dados de grande significância relacionados ao salto vertical, o qual avaliou a potência muscular, contudo, através do teste de Illinois obteve- se ganhos relacionados a agilidade dos indivíduos do grupo foamroller quando comparado aos demais. Conclusão: Pode-se concluir com os dados do presente estudo, que o uso do foamroller, como estratégia na auto liberação miofascial, se mostrou eficiente para a agilidade dos participantes, contudo não apresentou dados tão significantes quando relacionados a potência muscular.
Effects of cranial osteopathic techniques in the symptoms of benign positional paroxistic vertical
Authors: Oliveira Otávio Augusto do Nascimento , Mesquita Laiana Sepúlveda de Andrade , Mendes Maurício Rocha , Oliveira Lílian Maria Magalhães Costa de , Almeida Laís Cristina
Published: November 2020

Background: The benign paroxysmal positional vertigo (BPPV) is the most common cause of dizziness among the population. The osteopathy is a practice of manual therapy which is guided by a holistic perspective of human being, the cranial osteopathy affirms that the respective bones of the cranium represent mobility. Objective: To investigate the effect of the cranial osteopathy techniques on the benign paroxysmal positional vertigo. Methods: The current study included 20 female subjects, each one of them with benign paroxysmal positional vertigo, distributed in two groups, an intervention group and a control group (placebo); in order to detect the BPPV, was applied the Dix-Hallpike test before and after the interventions. Three techniques of cranial osteopathy were used on the structures related to vestibule and to the temporal bones: mobilization of temporal bones, tensioning of cerebellar tentorium and mobilization of eyeball. All statistical analyzes were performed using the GraphPad Prism 6.0 software (GraphPad Software, CA).Results: Among the intervention group, 7 of 10 individuals were negative to the Dix-Hallpike test, whilst individuals of the control group remained positive to the test. In the statistical analysis verified that the intervention with osteopathic techniques had a significant effect in compared to the control group, with a value p=0.0261. Conclusion: The cranial osteopathy appears to be able of produce effects on the vestibular activity, whereas were able to reduce, in a significant means, the symptoms concerning to BPPV.
Induced Contention Therapy and functional bandage in children with cerebral palsy: Case report
Authors: Bortoli Priscila Oliveira , Dutra Letícia Ramos , Knabben Rodrigo José , Marques Claudia Mirian de Godoy , Martinello Micheli
Published: November 2020

Background: The decrease in the manual activity of hemiparetic children, affects their functionality and independence. Among the therapies used to improve manual function, there is Induced Contention Therapy (ICT) and functional bandaging (FB). Such approaches aim to improve the use and decrease the disuse learned from the upper limb in subjects with hemiparesis. Objective: Identify the effect of ICT, associated with the application of functional bandaging on the affected upper limb, in the function of the upper limb and on the handgrip of a child with spastic hemiplegic cerebral palsy. Methods: A 5-year-old child received ICT for three hours daily for three consecutive weeks associated with FB in the right upper limb. The use of the upper limb was evaluated using the Pediatric Upper Extremity Motor Activity Log (PMAL) scale, the acquisition of new motor standards using the Inventory of New Motor Activities and Program (INMAP) scale, the motor skill by the Pediatric Arm Functional Test (PAFT) and the handgrip strength by the dynamometer. Results: There was an improvement in the quantity and quality of use of the paretic upper limb after the application of ICT, which remained after one month of therapy. In addition, it was observed the acquisition of new motor skills and improvement in handgrip strength. Conclusion: This study had a potential positive effect on handgrip strength, functionality and quality of use of the paretic upper limb of a child with spastic CP after the application of ICT associated with functional bandaging.
Europeísmo(s) en la posguerra: la opción británica por la cooperación intergubernamental
Authors: Dominguez Castro Luis , González Fernández Sara
Published: November 2020

Europeísmo o europeísmos no es un falso dilema. El relato canónico de un proceso de integración europea diseñado por Monnet y desarrollado por las Comunidades está definitivamente cuestionado. Hay y hubo otras alternativas que no deben encajonarse bajo el epígrafe de euroescepticismo. La cooperación intergubernamental defendida por Gran Bretaña tuvo y tiene más recorrido del que se le ha querido reconocer aunque por diversas razones no logró liderar el proceso de integración, en el que, por otra parte, nunca creyó. La Unión Occidental, patrocinada por los laboristas, y el Consejo de Europa, inspirado por Churchill, merecen una revisión histórica que este trabajo quiere, modestamente, contribuir a realizar
Challenging the Origins of Euroscepticism. A Historical Perspective
Authors: Birte Wassenberg
Published: November 2020

Este artículo cuestiona la corriente ortodoxa en las ciencias políticas sobre el origen del euroescepticismo. En primer lugar, niega que el euroescepticismo nació en el Reino Unido en la década de 1980 y que fuera promovido principalmente por partidos políticos británicos y el Gobierno de Thatcher. Si se define como oposición a la idea de una Europa federal, el euroescepticismo puede remontarse, en efecto, a los comienzos del proceso de integración europea después de la Segunda Guerra Mundial y puede ser seguido continuamente hasta nuestros días. En segundo lugar, el artículo cuestiona el fin del «consenso permisivo» en la década de 1990, argumentando que, si bien la oposición de la población europea frente a la UE ha aumentado desde entonces, esto se debe más bien a la organización frecuente de referéndums. En tercer lugar, mientras que los partidos políticos euroescépticos han ganado progresivamente su apoyo en las elecciones europeas desde la década del 2000, la posibilidad de que los ciudadanos europeos expresen sus sentimientos antieuropeos ya ha existido desde la introducción de las primeras elecciones europeas por sufragio universal en 1979. Por último, el artículo identifica un vínculo más bien paradójico entre las elecciones europeas y el euroescepticismo, especialmente cuando se considera el elevado índice de abstenciones.
Las instituciones europeas ante la crisis del Estado de derecho en Hungría y Polonia
Authors: Becerril Atienza Beén
Published: November 2020

Este artículo aborda la crisis del Estado de derecho en Hungría y Polonia, situándola en el marco de la historia de la integración europea. Desde mediados de los años noventa, la Unión se fue dotando progresivamente de procedimientos específicos con el fin de que sus instituciones pudiesen responder a una eventual vulneración de sus valores por parte de un Estado miembro. Este proceso respondía particularmente a la inminencia de una quinta ampliación cuya dimensión no tenía precedentes y que habría de incorporar a Estados de corta trayectoria democrática. Años después, en un contexto marcado por el auge de los populismos, la deriva iliberal de los Gobiernos húngaro y polaco ha provocado el primer uso de los nuevos procedimientos, poniendo de manifiesto su insuficiencia ante una crisis de esta naturaleza y mostrando los límites de la capacidad de influencia de la Unión Europea después de la adhesión.
The institutionalisation of a new social policy in the Portuguese Estado Novo. The struggle for a corporatist welfare (1933-1945)
Authors: Rodrigues Garrido Álvaro Francisco
Published: November 2020

Este artículo debate sobre los objetivos de la política social y de las instituciones de los regímenes fascistas. Considerando el concepto de fascismo de forma más amplia y no basado exclusivamente en la experiencia fascista italiana, este análisis se centra en el régimen corporativista del Estado Nuevo portugués. Teniendo en cuenta que en el contexto de entreguerras el corporativismo era una forma de construir políticas sociales específicas y autoritarias, este artículo expone las estructuras institucionales portuguesas para el bienestar y analiza sus objetivos instrumentales. Comparando la experiencia portuguesa con otros sistemas corporativistas, ¿hubo un welfare corporativista? ¿Fue esta una nueva política social conectada a la modernización económica y capaz de competir con el Estado de bienestar democrático? Estas preguntas clave se responden mediante el análisis de las contradicciones del sistema social corporativo portugués de Salazar, su falta de universalidad y su desconexión con los derechos sociales.
La oferta del Nuevo Estado. Propaganda e ideologización del combatiente sublevado en la Guerra Civil española (1936-1939)
Authors: Alonso Ibarra Miguel
Published: November 2020

En los últimos años, la historiografía ha abordado el proceso constructivo del régimen franquista a través del estudio de la experiencia bélica de los combatientes sublevados durante la guerra civil española (1936-‍1939). Esto ha conducido a dos interpretaciones fundamentales: que la principal función del Ejército fue eminentemente coercitiva, y que el adoctrinamiento estaba subordinado a ella. Consecuentemente, no se dio una experiencia de ideologización significativa entre los combatientes rebeldes. Partiendo de este marco, el artículo busca cuestionar ambas ideas, sosteniendo que sí existió un proceso de ideologización de los soldados sublevados en el que además el Ejército tuvo un papel crucial, lo que permite reconsiderar la relevancia de sus políticas de adoctrinamiento. A través de un análisis de la documentación militar referida a estas políticas, tanto a nivel general como descendiendo a casos divisionales específicos, e incorporando también la perspectiva de los propios combatientes a través de sus diarios de guerra, se ahondará en las formas y temas de dicha propaganda, argumentando que fue la vía pragmática, más que la ideológica, la que favoreció la atracción de los combatientes hacia el nuevo Estado. Un enfoque que permitiría entender cómo se construyeron los apoyos sociales a la dictadura entre el colectivo de los excombatientes, y en general en el conjunto de la sociedad española.
Helicobacter pylori and IL-23R gene polymorphism role in degeneration of gastric mucosa
Authors: Zandi Farid , Shirzad Hedayatollah
Published: November 2020

Relationship between H.pylori (Hp) colonizes and gastric inflammation is widely accepted. Polymorphisms in inflammation related genes such as cytokines and their receptors were thought to partly determine the outcome of Hp infection. Interleukin 23 receptor (IL23R) may relate to degeneration of gastric mucosa. We evaluate association of IL23R +2199 rs10889677 polymorphism and grade of Hp infection with degeneration of gastric mucosa and grade of Hp infection. Biopsies taken from the corpus patients were classified as Hp-infected and Hp-uninfected. The histological severity of Hp infection and degeneration of gastric mucosa were graded from normal to severe. Polymorphism in IL23R was evaluated by PCR-RFLP. AC genotype was related to mild degeneration in Hp-infected subjects (P=0.017). Mild and moderate grades of Hp infection were found related to mild grade of gastric mucosal degeneration (P=0.004 for mild and P=0.037 for moderate grade), sever grade was associated with non-degeneration (P=0.010). We didn’t found any association between IL-23R +2199 polymorphism and grades of Hp infection (P>0.05). We concluded that AC genotype of IL-23R polymorphism influences degeneration of gastric mucosa according to presence of Hp and grades of Hp infection.
A novel role of peptidyl-prolyl isomerase-1 as inducer of IL-6 expression in systemic lupus erythematosus
Authors: R Takeno Michael , B Gunn Jacob
Published: November 2020

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with various clinical manifestations affecting different tissues. Pro-inflammatory cytokines, such as interleukin 1β, IL-6 and IFN-g are associated with the SLE progression; however, the precise molecular mechanisms that in occurs improper cytokines production in SLE remain unknown. Autoantibody production and renal disease were evaluated in NZB/W F1 mice treated with a specific Pin1 inhibitor, Juglone. Inhibition of Pin1 activity significantly suppressed the IL-6 expression in NZB/W F1 mice and developed milder renal lesions than the lesions developing in non Juglone-treated mice. We further found that Pin1 inhibitor treatment suppresses B-cell differentiation and T-cell activation in NZB/W F1 lupus mice. Finally, stat3 phosphorylation was decreased in T cells from Pin1inhibitor-treated mice at 40 weeks of age as compared to that from the saline and isotype control mAb treatment groups. This is the first study to demonstrate that Pin1 plays critical roles in SLE development. Pin1 inhibition to the appropriate level might provide a novel therapeutic strategy target for future SLE therapies.
High-mobility group box-1 protein induce inflammatory response after pulmonary injury
Authors: H Golemis Jingxian , J Rudensky Laurie
Published: November 2020

High-mobility group box 1 (HMGB1), a highly conserved non-histone chromosomal protein, was found to act as a potent proinflammatory cytokine and a mediator that participated in the development of systemic inflammatory response. Forty wild type C57BL/6 male (25-30gms) mice were randomly divided into three groups: saline control group; anti-HMGB1 antibody treated group and untreated group. Each group received intratracheal instillation twice per week for 4 consecutive months. 24 hours after the last exposure, anaesthetize the mice with chloral hydrate, bronchoalveolar lavage fluid was collected for cytokines analysis were measured by enzyme linked immunosorbent assay (ELISA). The level of the HMGB1 in lung tissue was determined by real-time PCR and western blot. Lung were fixed with 4% paraformaldehyde for histopathological detection. The serum level of HMGB1 increased after lung injury [peaked 2-5 hr] after lung injury, furthermore this upregulation in HMGB1 associated with increased proinflammatory cytokines [TNF-α, IL-6, IL-1β]. The injection of anti-HMGB1 antibody suppressed inflammatory reaction and improved the survival rate compared with control mice [71.3% vs. 29.4% P=0.031]
The “Multicellular Origin” of Cancer and the Clonal Evolution of Oncogenesis
Authors: Karindas M. Mark
Published: November 2020

Cancer cells are the result of the multi-step, multi-dimensional and multi-generational process of oncogenesis, but they are never the products of cellular transformation. When a stem cell divides, asymmetrically or symmetrically, it produces two new (new generation) cells, a differentiated daughter cell and a daughter which is a parent-identical stem-cell, or two identical daughter stem cells, respectively. In either case, the daughter cells, differentiated or parent-identical, have their own individuality and character. A daughter cell is not a transformed parent cell; it has its own cellular identity, genotype and phenotype although it carries its parent’s genotypical and phenotypical features. The term “Cellular Transformation” in today’s Medical Research Literature, which refers to neoplastic cellular changes, is unintentionally amiss, but scientifically delusive; it implies a solitary cellular reign that misleadingly suggests a “single cell” origin for oncogenesis. In any living multicellular organism, whose multicellular existence and functionality is totally based on intercellular subsistence, a multicellular act or happening is absolutely impossible to start with or from a solitary cell action. In multicellular organisms, in vivo, malignant neoplasms, including leukemias, which all are the products of highly organized cellular teamwork from the very beginning, never arise from single cells; they arise from groups of cells.
The possible immunopathogenesis of SARS-Cov-2 Infection - A review of immune changes in patients with COVID-19
Authors: Fatima Syeda Hajra , Viquar Uzma , Ahmed Tasleem , Kazmi Munawwar Hussian
Published: November 2020

A highly infectious outbreak of Coronavirus disease (COVID-19) caused by a new coronavirus - Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) was first officially reported in December 2019 in Wuhan, China which spread rapidly worldwide infecting millions of people in many countries. Although most of infected patients are asymptomatic or develop mild symptoms that usually recover with good prognosis, 10-20% of infected people especially old age and those with underlying medical co-morbidity conditions, develops severe disease with multiple organ failure, primarily respiratory failure and death. SARS-CoV-2 infection shares similar genetics, pathogenic, epidemiological and clinical features with two other viruses belonging to same coronavirus family that have caused serious infections over the last two decades i.e SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) and MERS-CoV (Middle East Respiratory Syndrome Coronavirus) and pathogenesis and immune changes observed in these infections can be applied to this new pandemic in order to learn the imperative role of the immune system during the course of coronavirus infections and possible use of immunomodulatory intervention and immunosuppressive drugs in management of severe patients. As the immunopathogenesis of SARS-CoV-2 infection is still not clear and understanding this underlying mechanism which leads to severe form of disease is important for identifying effective treatment for critically ill patients, this article reviews the immunopathogenic changes observed in SARS-CoV-2 infection and identify the possible mechanisms by which it induces immune changes including cytokine storm, in order to provide a reference for the early clinical identification and management of severe form of COVID-19 infection.
La capacitación, la enseñanza y la investigación para una política de reconstrucción nacional en el área de la salud
Authors: Testa Mario
Published: November 2020

Este texto reproduce el discurso pronunciado por el Dr. Mario Testa, el 28 de junio de 1973, en el aula magna de la Facultad de Medicina de la Universidad de Buenos Aires. Las líneas introductorias que lo anteceden, escritas por el propio autor, contextualizan no solo el momento histórico de aquella universidad, a pocos días de la asunción de Rodolfo Puiggrós como rector interventor, sino el sentido del proyecto de renovación pedagógica que proponía una redefinición de la relación entre universidad y sociedad y que dio origen a proyectos como el Instituto de Medicina del Trabajo, el Instituto de la Madre y el Niño y el Instituto de Patología Regional, en la Facultad de Medicina; el Centro de Producción de Medicamentos de Base en la Facultad de Farmacia y Bioquímica; el de Erradicación de Villas de Emergencia en la Facultad de Arquitectura, entre tantos otros. Volver a publicar aquellas palabras pronunciadas hace casi 40 años es poner en discusión el significado y el sentido de la formación de profesionales de la salud financiada con fondos públicos.
PROMOTING YOUTH’S SELF-EMPOWERMENT IN RESIDENTIAL CARE — THE INFLUENCE OF THE ORGANISATION: THE FIRST YEAR OF THE PROJECT “CREATING FUTURES” AND ITS SWISS–HUNGARIAN COMMUNITY OF PRACTICE
Authors: Schmid Anna
Published: November 2020

In the project “Creating Futures”, youths, staff, and leaders from youth homes in Switzerland and Hungary collaborate in a Community of Practice. Their goal is to develop organisational innovations that allow each of the youth homes to more effectively promote the self-empowerment of young people: their ability to take charge of their own lives and realise their own ideas of the future. This paper reports results, learnings, and first impacts regarding both the topic and the collaborative process in the project’s first formalised year, 2019. In developing its ways of working, the Community of Practice aims to engage as many persons as possible in each youth home. Through focus group discussions, a literature review, and a Young Expert Exchange, organisational factors that promote self-empowerment in residential care have been identified. Representatives of each youth home have selected those of most interest and have begun to assess their existing good practice as well as needs and potentials for innovation. The article includes the voices of participants as it reflects on the requirements for, and benefits and challenges of, youth participation and collaboration within a highly diverse Community of Practice.