bluuebunny/crossref_metadata_2025 huggingface dataset:
İmam Eş'ari ve Eş'arilik
Authors: Altıparmak Gökçek Buşra
Published: December 2024

Türkiye’de çağdaş araştırmalar söz konusu olduğunda farklı disiplinlerin perspektifinden hem mezheplerin hem de fırkaların araştırma konusu yapıldığını görmekteyiz. Bu çalışmalara konu olan yapılardan biri de itikadî sahada varlık kazanmış olan Eş‘arîliktir. Bu doğrultuda çalışmamızda Eş‘arîlik adlı fırkayla ilgili olarak Mehmet Keskin tarafından kaleme alınan İmam Eş‘arî ve Eş‘arîlik başlıklı kitabın tanıtımı yapılacaktır
Sünnî ve Şiî Tefsir Kaynaklarında Ehl-i Zeyğ
Authors: Alimoğlu Sürmeli Zeynep
Published: December 2024

İslam düşüncesinde ortaya çıkan fırkalar hakkında gerek müntesipler gerekse muhalifler tarafından çeşitli isim veya nitelemeler kullanılmıştır. Bu isim ve nitelemelerin bir kısmı övgü içerirken bir kısmı ise yergi içermektedir. Övgü içerikli isim ve nitelemeler meşruiyet gayesi; yergi içerikli isimler ve nitelemeler ise ilgili grubu gayrı meşrulaştırma gayesi ile çeşitli ayet ve hadislere müracaat edilerek kullanılmıştır. Bu hususta kullanılan nitelemelerden biri de Ehl-i zeyğ ibaresidir. Kavram, Âl-i İmran sûresi 7. ayette geçen “kalplerinde zeyğ olanlar” ifadesinden mülhem olarak yergi maksatlı muhalifler hakkında kullanılmıştır. Ancak zeyğ kavramı, nüzûlü itibari ile Ehl-i kitap hakkında küfür bağlamında kullanılmış bir nitelemedir. Bununla beraber mezheplerin teşekkül etmesi ile mevzubahis niteleme, gerek Sünnî gerekse Şiî gelenekte İslam bünyesinde ortaya çıkmış bazı fırkalar hakkında kullanılmaya başlanmıştır. Bu makale, kullanımın dayanak kılındığı ayetlerin Sünnî ve Şiî Tefsirlerde yorumlanma biçimini incelemektedir. Bir makalenin sınırlarının aşılmaması için bu çalışmada, kullanıma dayanak kılınan ayetlerin tefsir eserlerinde fırkalar ile ilişkilendirilmesi meselesine yoğunlaşılmış; konuya dair diğer kaynaklardaki malumat ise ayrı bir çalışma olarak planlanmıştır.
İmam Mâtürîdî’nin Din – Siyaset İlişkisinde Akıl ve Vahiy Dengesi: Epistemolojik Bir Yaklaşım
Authors: Tunç Mehmet Fatih , Teber Ömer Faruk
Published: December 2024

İslâm’ın kelâmî yapılanmasında öne çıkan Mâtürîdî, din-siyaset bağlamındaki görüşleri de gittikçe ilgi odağı haline gelmiştir. İslâm düşünce geleneğinde din ve siyaset arasındaki ilişki, değişmez dinî ilkelerle zamana ve topluma göre şekillenen siyaset arasındaki dengenin nasıl kurulacağı üzerine yoğunlaşır. O, bu dengeyi akıl ve vahiy arasında kurduğu özgün ilişkiyle ele alır. Ona göre akıl, dinî hükümleri anlamada ve siyasal kararlar almada kullanılırken, vahiy bu kararların ilahî otoriteye dayandırılmasını sağlar. Mâtürîdî’nin bu yaklaşımı, din ve siyasetin uyumuna ve İslâm siyaset düşüncesine önemli bir katkı sunar. Mâtürîdî’nin din-siyaset ilişkisine yönelik epistemolojik düşüncesi, aklın ve vahyin birlikte hareket etmesine dayanır. Burada dikkat çekilen husus, belirli bir bilginin sunulması değil bilginin nasıl elde edildiği ve ne ölçüde güvenilir olduğudur. Bu düşünce, toplumsal ve siyasal alanda uygulanabilir olmasını sağlamaya yönelik bilgi üretme alanıdır. Makaleden İslâm düşüncesine ve modern siyasal tartışmalara önemli katkılar sunması hedeflenmektedir. Makâle, Mâtürîdî’nin din-siyaset ilişkisi üzerindeki düşüncelerinin odak noktasını oluşturan akıl-vahiy dengesi, te’vil anlayışı, bilgi anlayışı, İman-amel ayrımı, Din-şerîat ayrımı düşüncesi, onun din-siyaset bakış açısının daha sistematik şekilde gündeme gelmesine ve konunun daha detaylı tartışılmasına zemin hazırlayacağı beklenmektedir.
Makâlât Yazarı Ebû ʿAmr Osman b. Halîfe es-Sûfî ve Muhaliflere Karşı Tutumu
Authors: Benras Mahmoud
Published: December 2024

Bu makalede İbâdî ekolünün önemli isimlerinden biri olan Ebû ʿAmr Osman bin Halîfe el-Mâregnî es-Sûfî'nin (VI. yy./XII. yy.) muhaliflere karşı tutumu ele alınmıştır. Kendi döneminin en önemli İbâdî bilgini kabul edilen es-Sûfî, İbâdî doktrinin Kuzey Afrika’da ilmi açıdan geliştiği dönem olan hicri altıncı yüzyılda yaşamıştır. Kendisine veya eserlerine yapılan atıflar ve eserlerinden yapılan aktarımların çokluğu bu durumu teyit etmektedir. Öte yandan diğer yazılı İbâdî mirasın çoğunluğunda olduğu gibi, onun eserlerine de henüz ulaşılabilmiş ve yakın tarihlerde ancak bir kısmı ilim dünyasının hizmetine sunulabilmiştir. Yazarın henüz tahkiki yapılmamış veya basılmamış birden çok eseri mevcuttur. Bu araştırmanın ana kaynaklarından olan, yazara ait Risâletü'l-firak, es-Sü’âlât, ve bu eserlerin şerhlerinin çoğunluğu henüz yazma haldedirler. es-Sûfî, İbâdiyye’den makâlât türü eser yazan ve İbâdî bilginlere hitap ettiği bilinen kökenli tek yazardır. Yazarın Hâricî-İbâdî literatüre vakıf olması ve eserler telif etmesi bu iki mezhebin ilmi terminolojisinin teşkili ve sonraki nesillere aktarılmasında yazara referans bir konum vermiştir. Günümüze ulaşan Îbâdî kitabiyyatın ortak İslamî ilimler havuzunda anlaşılabilir bir seviyeye ulaşmasında yazar önemli bir konuma sahiptir. Bu makalede es-Sûfî’nin, İbâdî bir bilgin olması sebebiyle İbâdiyye içerisindeki farklı görüşlerle, muhalif mezhep ve akımlara yönelik tutumu araştırılıp ortaya konulmuştur.
Hanbelîliğin Eş‘arîleşmesi Hicrî IV-VI. Yüzyılda Bağdat Örneği
Authors: Oğuz Elif
Published: December 2024

Öz
Mezhepler arası ilişkilerin zaman, mekân ve bağlam çerçevesinde incelenmesi, düşünce ekollerinin gelişim süreçlerinin ve kırılma noktalarının anlaşılmasında önemli bir perspektif sunmaktadır. İslam düşünce tarihinde itikadî meselelerde katı duruşuyla bilinen Hanbelî mezhebi, hicrî IV-VI. yüzyıllarda Bağdat’ta yaşanan siyasî ve entelektüel gelişmelerin etkisiyle önemli fikirsel dönüşümler geçirmiştir. Bu bağlamda Mustafa Karatay'ın Hanbelîliğin Eş‘arîleşmesi: Hicrî IV-VI. Yüzyılda Bağdat Örneği adlı eseri, Hanbelî mezhebinin Eş‘arî düşünceyle olan etkileşimini detaylı bir şekilde ele almaktadır. Çalışma, mezhepler arası ilişkilere karşıtlık üzerinden değil, etkileşim açısından yaklaşmakta, Hanbelîlik ve Eş‘arîlik arasındaki bu fikrî etkileşimi âlimler ve teolojik meseleler çerçevesinde analiz etmektedir. Karatay’ın bu eseri, Hanbelî mezhebinin Eş‘arî düşünceye yönelme sürecini, dönemin ilmî ve siyasî dinamikleri doğrultusunda derinlemesine incelemekte ve bu iki ekol arasındaki etkileşime dair önemli bir bakış açısı sunmaktadır.
Hikmet Kavramı Üzerinden Alevi Gelenek Hakkında Bir İnceleme
Authors: Üçer Cenksu
Published: December 2024

Bu çalışmada Alevî nitelemeli gelenekte hikmet anlayışı incelenmektedir. İslam Mezhepleri Tarihi alanında zihniyet analizi üzerinde önemle durulmaktadır. Zihniyet analizinde, yapılan çözümlemelerin ana unsurlarından biri kavramlardır. Zira her mezhep, ekol ve geleneğin zihniyeti, kavramlara yüklediği anlamlarla şekillenmektedir. Hikmet kavramı farklı mezhep, ekol ve geleneklerde var olan ana kavramlardandır. Alevî nitelemeli gelenekte hikmet anlayışının ortaya konulması, hakkında farklı tartışmaların bulunduğu bu geleneğin konumunun anlaşılmasına katkı sağlayacaktır. Çalışmada yakın zamanda daha çok Alevî kelimesiyle nitelendirilen; geleneksel olarak ise Ağuçan, Dede Garkın, Hacı Bektaş, Hıdır Abdal, Hubyar, Şücaaddin Velî, Uryan Hızır gibi ocak isimleriyle anılan gelenek mensuplarında hikmet anlayışının incelenmesi amaçlanmaktadır. Araştırmanın temel hipotezi, Alevî gelenekteki hikmet anlayışının, geleneğin tasavvuf karakteri ve Yesevîlik’le irtibatı dolayısıyla genelde tasavvuf özelde İslam kültür ve geleneğinin bir parçası/yansıması olan Yesevîlik’teki hikmet anlayışı ile mütenasip olacağı şeklindedir. Nitel hüviyetli bu araştırmada hikmet kavramı bağımlı değişken; tasavvuf, Yesevîlik ve Alevî gelenek bağımsız değişkenler olarak belirlenmiştir. Fenomenolojik yaklaşım esas alınarak yürütülen araştırmada doküman taraması kapsamında özellikle Yesevî hikmetlerine dair eserler ile Alevî gelenekte önemli görülen deyiş/nefesleri içeren eserler taranmış, elde edilen veriler deskriptif/tasviri yaklaşım çerçevesinde bağımsız değişkenlere göre mukayeseli bir şekilde incelenerek içerik analizi yapılmıştır. Alevî gelenekteki hikmet anlayışının gerek tasavvuf gerek Yesevîlik geleneğindeki hikmet anlayışı ile örtüştüğü görülmektedir.
The Concept of Parafree Zinbiel Algebras
Authors: Çiloğlu Şahin Zekiye
Published: December 2024

Pf (parafree) Zinbiel (PfZin) algebras, a generalization of Leibniz algebras, share various traits with free Zinbiel algebras. This article delves into the intricacies of PfZin algebras, presenting their structure and exploring significant findings analogous to those in parafree Leibniz algebras. The focus extends to properties of subalgebras and quotient algebras within the realm of PfZin algebras. Additionally, the direct sum of these algebras is examined, demonstrating that the amalgamation of two PfZin algebras yields a Zinbiel algebra. A new connection between weak Hopf algebras and PfZin algeras constructed. Moreover, from the direct sum of PfZin algebras weak Hopf algebra is handled and construction of weak Hopf algebra usuing PfZin algebra is showed.
The Determination of Molecular Electrostatic Potential and Anticancer Properties of Eugenol: A Theoretical Study
Authors: Bıçak Bilge
Published: December 2024

Cancer is one of the deadliest diseases worldwide, and for this reason, it is a prominent field of study in drug development. It has been reported in various studies that some of the plants and essential oils obtained from plants have high anticancer activities. This situation is related to the compound groups found in plants and essential oils. Studies on using essential oils in combination with synthetic drugs or aromatherapy are ongoing. Essential oils show cytotoxic properties and may play a role in the death of cancer cells. Eugenol is an important compound found in clove, laurel, and cinnamon essential oils that has anticancer activity in various types of cancer. Eugenol has the ability to reduce cyclooxygenase-2 (COX-2) activity and to inhibit cell proliferation through NF-κB suppression in various types of cancer. In this study, the binding profiles of eugenol with COX-2 and Human inhibitor of nuclear transcription factor κB (IkB) kinase beta, which plays a crucial role in the NF-κB signaling pathway, were examined by molecular docking study, which is one of the methods used in computer-aided drug design. A supporting study was performed to understand the electrostatic complementarity between ligand and receptor by molecular electrostatic potential (MEP) analysis. As a result of the study, it was comparatively presented that eugenol has similar interaction profiles with reference compounds.
Use of Active Carbon Produced by Hydrothermal Method from Agricultural Waste in Methylene Blue Removal
Authors: Boyrazlı Mustafa , Arancı Öztürk Elif , Çelik Emrah , Yasli Mehmet Ali
Published: December 2024

In this study, the use of activated carbon produced from agricultural waste via the hydrothermal method for the removal of methylene blue from solution was examined. Pistachio roasting facility waste was selected as the agricultural waste. For activated carbon production, carbonized products were treated in a hydrothermal device in the presence of an activator for various durations. During processes conducted at a constant temperature, high pressure was achieved, allowing the activated carbon to attain a high adsorption capacity. The results showed that the sample with a KOH impregnation ratio of 1:1, treated in a hydrothermal device for 480 minutes at 160 °C, was able to remove methylene blue with a 99.85% extraction yield in a solution with a 350 ppm methylene blue concentration.
Thermal Performance Analysis of a Liquid Cooling Plate for Power Electronics
Authors: Akgül M. Bahattin , Erçel Furkan Sinan
Published: December 2024

The need for effective cooling methods has become very critical because of the miniaturization and increasing heat flux density in power electronics equipment. The power electronics systems must have good thermal management engineering for efficiency and safe operation. Due to increasing heat loads, liquid cooling options are more preferred than the air cooling solutions. In this study, thermal performance of a liquid cooling plate is investigated by using computational fluid dynamics (CFD) tools. Different flow path configurations are examined for homogeneous and effective cooling of power electronics equipments with high power density. The pressure losses, surface temperatures and thermal resistances at different coolant flow rates are computed and compared together. Moreover, the influence of the cooling channel height and width on the thermal thermal performance is analyzed.
Investigation of Dielectric Anisotropy and Electrical Modulus-Impedance Properties of PCBM/E7 Composite for Organic Electronic Devices Applications
Authors: Demir Ahmet , Musatat Ahmad Badreddin , Kip Şule Zeynep
Published: December 2024

This study investigates the dielectric anisotropy and electrical modulus-impedance properties of a PCBM/E7 composite material for organic electronic devices applications. The research examines a specially fabricated cell combining nematic liquid crystal E7 with [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) semiconductor. Through comprehensive analysis of dielectric anisotropy, AC conductivity, electrical modulus, and impedance characteristics under varying frequencies and applied voltages (-6.0V to +6.0V), the study reveals distinct behavioral regions and multiple relaxation processes. Key findings include frequency-dependent dielectric anisotropy transitions, enhanced AC conductivity at higher frequencies and voltages, and voltage-modulated impedance characteristics. The observed dual-peak phase angle response suggests multiple relaxation mechanisms, indicating the composite's potential for voltage-tunable electrical properties in advanced optoelectronic applications.
A New Record of Genus Stigmaeus (Acariformes: Stigmaeidae) from Türkiye
Authors: Akyol Mustafa
Published: December 2024

Stigmaeus canestrinii Stathakis, Kapaxidi and Papadoulis, 2019 is founded for the first time from Türkiye and new report the mite fauna of Türkiye. Mites taken from soil and litter samples under Oleae europaea (Oleaceae) Manisa province, Türkiye. S. canestrinii is redescribed and illustrated based on the adult female.
Molecular Pathways Underlying the Therapeutic Effect of Stem Cells During Asthmatic Changes
Authors: Berenji Bahar Saljoughi , Mirershadi Fatemeh
Published: December 2024

Allergic asthma is a chronic inflammatory disease characterized by airway remodeling, hyperresponsiveness, and exacerbated inflammation. While most patients respond well to current treatments, a small subset remains resistant necessitating new therapeutic strategies. Due to their immunomodulatory properties, stem cells have been proposed as a promising treatment option for asthma. Stem cells can reduce airway inflammation and restore immune balance, demonstrating positive outcomes, particularly in cases of steroid-resistant asthma. However, the mechanisms underlying lung tissue repair are not clearly defined. On the other hand, there are limitations in using these cells and for clinical use of mesenchymal stem cells, which must be produced in accordance with Good Manufacturing Practice. This review article discusses the mechanisms by which stem cells may aid in asthma treatment and addresses and explores the challenges associated with their use. By addressing these areas, we can better understand the potential and limitations of stem cell therapy in asthma and develop more effective strategies to harness their therapeutic benefits for patients with uncontrolled asthma.
The Role of Th17/Treg Imbalance, FeNO, Eosinophils, IgE and Their Correlation with Lung Function Parameters with Asthma-Chronic Obstructive Pulmonary Disease
Authors: Xie Chenli , Xu Weixia , Rao Shuke , Xie Yanshen , Liang Qingting , Chen Lichong , Yuan Weiliang , Xie Ying , Li Huafeng , Xu Guihua
Published: December 2024

This study explored the link between clinical features, immune markers, and asthma-chronic obstructive pulmonary disease overlap (ACO), aiming to enhance diagnostic precision and tailor treatment.
The study included 60 patients per group: COPD patients, ACO patients, and healthy controls. Biological indicators such as fractional exhaled nitric oxide (FeNO), eosinophils, immunoglobulin E (IgE), T helper (Th) 17 cell counts, regulatory T-cell (Treg) counts, and cytokine levels of interleukin-17 (IL-17) and interleukin-10 (IL-10) were measured using standard enzyme-linked immunosorbent assay and flow cytometry techniques.
Elevated Th17 cells, IL-17, and Th17/Treg ratio, alongside reduced IL-10 and Treg levels, were observed in COPD and ACO patients. ACO patients showed worse lung function, with a negative correlation between FeNO, Th17 cells, Th17/Treg ratio, IL-17, and lung function indices, and a positive correlation with residual volume/total lung capacity (RV/TLC) ratio.
The study suggests that Th17/Treg imbalance, FeNO, eosinophils, and IgE could be key in ACO pathogenesis, potentially aiding early diagnosis and targeted treatment. Future research may utilize these findings to develop preventative and therapeutic strategies for ACO.
Exploring the Association Between Blood Indices and Skin and Joint Activity of Psoriatic Arthritis
Authors: Rostamian Abdolrahman , Aghayani Shila , Najafizadeh Seyed Reza , Saffarian Zahra , Yaseri Maryam
Published: December 2024

The exact cause of psoriatic arthritis is still unknown, but hypotheses suggest the role of hematological parameters in the onset and severity of the disease. This study evaluated the hematological indices and their association with skin and joint activity in psoriatic arthritis.
This cross-sectional study included 74 patients with psoriatic arthritis. Demographical and clinical data, blood indices, psoriasis area and severity index (PASI) score and disease activity in psoriatic arthritis (DAPSA) scores were calculated for all patients.
The mean age of the patients was 48.89±12.03 years and most were female (n=49). A significant correlation was observed between age and number of underlying diseases with PASI and DAPSA scores. Mean PASI and DAPSA scores were 5.19 and 15.13, respectively. The severity of psoriasis was mild in 58.1%, moderate in 36.5%, and severe in 4.5% of the cases. The activity of psoriatic arthritis was improved in 2.1%, low in 55.4%, moderate in 24.3%, and high in 1.8% of the patients. A significant association was found between erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), platelet (PLT) count, mean platelet volume (MPV), and PASI scores, while no statistically significant association was reported for PLR. A significant correlation was observed between ESR, CRP, RDW, NLR, PLR, PLT, and DAPSA scores, while no statistically significant association was found for MPV.
The findings indicated that inflammatory and hematological markers can be helpful factors in evaluating the severity of psoriasis and psoriatic arthritis.
Bioinformatics-driven Identification of lncRNA LINC02381 in Mediating Cisplatin Resistance via IL-12 Induced Wnt/TCF7 Signaling in Ovarian Cancer
Authors: Pazoki Zeinab Karbalaei , Hosseini Mostafa , Irani Shiva , Soltani Bahram Mohammad
Published: December 2024

Cisplatin resistance presents a considerable hurdle in the treatment of ovarian cancer, significantly impacting patient outcomes and limiting the effectiveness of chemotherapy. This study employs advanced bioinformatics techniques-including RNA sequencing (RNA-seq), DNA sequencing (DNA-seq), and chromatin immunoprecipitation sequencing (ChIP-seq)-to elucidate the molecular mechanisms underlying this resistance, with a particular focus on the long non-coding RNA (lncRNA) LINC02381.
Our findings reveal that LINC02381 is significantly upregulated in ovarian cancer cells exhibiting resistance to cisplatin, suggesting its pivotal role in mediating this phenomenon. We further demonstrate that cytokines, particularly interleukin-12 (IL-12), secreted by immune cells within the tumor microenvironment, activate the Wnt signaling pathway. This activation leads to the binding of the transcription factor TCF7 to the promoter region of LINC02381, resulting in enhanced expression of this lncRNA.
Notably, this interaction establishes a positive feedback loop in which LINC02381 not only promotes its own expression but also amplifies Wnt signaling activity. This cascade ultimately drives the upregulation of ATP-binding cassette (ABC) transporters, which are crucial for the efflux of cisplatin from cancer cells. Thus, the drug's intracellular concentration is reduced, and cell survival under chemotherapy pressure is facilitated. These insights uncover a novel mechanism of cisplatin resistance driven by the IL-12/Wnt/TCF7/LINC02381 axis, highlighting the complex interplay between immune signaling and drug resistance in ovarian cancer.
Our findings suggest that targeting this regulatory pathway may offer promising therapeutic strategies to overcome chemotherapy resistance, paving the way for improved treatment outcomes in patients with ovarian cancer. Future research should focus on validating these mechanisms and exploring potential interventions that disrupt this feedback loop.
Artificial Intelligence-Powered Cognitive Behavioral Therapy Chatbots, a Systematic Review
Authors: Farzan Maryam , Ebrahimi Hamid , Pourali Maryam , Sabeti Fatemeh
Published: December 2024

Objective: This review identifies the characteristic features of artificial intelligence (AI) chatbots and their therapeutic effect; assesses their efficacy in treatment of depression, anxiety, and other mental health disorders; and establishes levels of user engagement and satisfaction.
Method: Searches were conducted on the PubMed, Embase, MEDLINE, CENTRAL, CINAHL, PsycINFO, and Google Scholar databases using a set of keywords such as, not limited to, AI cognitive behavioral therapy (AI CBT), Youper, Wysa, Woebot, and other related terms. We included studies that were empirical, peer-reviewed, conducted between January 2017 and June 2024, and primarily focused on efficacy regarding the interventions and therapeutic outcomes. Data were then extracted and analyzed using both qualitative and quantitative methods concerning the mental health outcome.
Results: Our review identified large improvements across the three chatbots in symptoms of mental health, as supported by the 10 included studies: five on Woebot, four on Wysa, and one on Youper. Woebot showed remarkable reductions in depression and anxiety with high user engagement; Wysa demonstrated similar improvements, especially in users with chronic pain or maternal mental health challenges; Youper also presented a significant symptom reduction, including a 48% decrease in depression and a 43% decrease in anxiety. Common benefits of all chatbots were the therapeutic alliance and a high rate of satisfaction among users. We have also discussed the included studies’ limitations; that is, study design shortcomings and lack of sample diversity.
Conclusion: AI CBT chatbots, including but not limited to Woebot, Wysa, and Youper, are highly promising because of their availability and effectiveness in mental health support. They provide a useful complement to standard therapy when professional help is unavailable, and offer constant engagement with tailored interventions. However, it is necessary that further studies investigate their potential impact as long-term intervention models and explore how they may be integrated into holistic mental health care systems.
Effects of B Vitamins on Symptoms and Cognitive Functions in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Authors: Agmashe Somayeh , Sadighi Gita , Radman Narges , Mazinani Robabeh
Published: December 2024

Objective: Schizophrenia which is a chronic disabling burdensome psychotic disorder has been treated with different antipsychotic medications. Some studies have reported a possible correlation between deficiency in minerals, nutrients and vitamins — mainly group B vitamins — and the development of schizophrenia. In the present study, we aimed to examine the effect of the B vitamin group as an adjuvant treatment to antipsychotics in individuals with chronic schizophrenia.
Method: In a randomized, double-blind clinical trial study, involving two groups of 25 patients with chronic schizophrenia, we compared the effects of a 12-week adjuvant treatment with a combination of B vitamins — B1 (15mg), B2 (15mg), B6 (10mg), B12 (10µg) and nicotinamide (50 mg) — with a placebo. The impact on negative, positive and cognitive symptoms of schizophrenia was assessed for both groups before the intervention (T0) and at 4, 8 and 12 weeks after the intervention (T1, T2, and T3, respectively).
Results: Following the treatment, negative symptoms scores decreased in the treatment group at 12 weeks following the beginning of the treatment (F (4, 45) = 464.7, P < 0.0001). Although a trend toward improvement in positive symptoms and cognitive scores was seen, these changes were not significant.
Conclusion: Our results suggest that selecting the group B vitamins as an adjuvant treatment to the antipsychotics may have beneficial effects on improving negative symptoms of patients with chronic schizophrenia.
Investigating the Relationship between Automatic Negative Thoughts and Experiential Avoidance with Psychological Distress and the Mediating Role of Cognitive Emotion Regulation in Patients with a History of Suicide Attempt
Authors: Alipour Ahmad , Rahimi Afsaneh , Shadnia Shahin , Rahimi Mitra , Evini Peyman Erfan Talab , Hosseini Sayed Masoud , Mostafazadeh Babak
Published: December 2024

Objective: Automatic negative thoughts have an important role in development of a persistent negative cognitive bias, which may ultimately result in suicidal ideation. The primary objective of the present study was to examine the relationship between automatic negative thoughts and experiential avoidance in relation to psychological distress.
Method: The study sample comprised 441 individuals who had attempted suicide. Participants underwent interviews utilizing standardized questionnaires including Automatic Thoughts Questionnaire, Kessler Psychological Distress Scale, Acceptance and Action Questionnaire–II, and Cognitive Emotion Regulation Questionnaire along with its nine subscales. After internal relationships assessment among the research variables, outlier detection was done using the boxplot analysis and standard deviation distance metrics. To analyze the direct and indirect associations between the input and output variables, Structural Equation Modeling (SEM) was employed. In addition, SPSS-28 and Amos 29 software were used to analyzed the data.
Results: The final model showed that automatic negative thoughts were significantly inversely associated with adaptive cognitive emotion regulation (β = -0.42, P ≤ 0.01) and significantly positively related to both maladaptive cognitive emotion regulation (β = 0.49, P ≤ 0.01) and psychological distress (β = 0.53, P < 0.01). Additionally, experiential avoidance showed a significant positive relationship with maladaptive cognitive emotion regulation (β = 0.22, P < 0.01).
Conclusion: This research demonstrated that automatic negative thoughts could worsen psychological distress through the regulation of cognitive emotion in those who had a history of suicide. By the clinical management of automatic negative thoughts and shifting individuals’ cognitive emotion regulation toward adaptive strategies, there is potential for a substantial reduction in suicidal ideation and attempts which can be evaluated in future clinical trials.
The Association of Serum Lactoferrin Level with Psychological Symptoms, Cognition, and Executive Function in Schizophrenia Patients
Authors: Hezaveh Niloufar Mahdavi , Rad Soheila Kianpour , Semnani Yousef , Bazaz Maryam Mousavi , Javadi Abdolreza
Published: December 2024

Objective: Lactoferrin, a glycoprotein, has known neuroprotective effects, yet its role in the pathophysiology of neuropsychiatric disorders, particularly schizophrenia, remains unclear. This study aims to assess changes in lactoferrin levels during different phases of schizophrenia and explore its relationship with cognitive symptoms and performance.
Method: This before/after interventional study involved 30 patients diagnosed with schizophrenia. Participants were evaluated at two time points: upon hospital admission and after the resolution of acute symptoms. The Positive and Negative Syndrome Scale (PANSS) was utilized to measure symptom severity, while the Brief Assessment of Cognition in Schizophrenia (BACS) assessed the neurocognitive function. Serum lactoferrin levels were quantified using the Enzyme-Linked Immunosorbent Assay (ELISA) method.
Results: Serum lactoferrin levels significantly decreased from 130.63 ± 52.49 ng/mL at admission to 85.42 ± 29.03 ng/mL at discharge (P < 0.001). No significant correlation was found between lactoferrin levels and PANSS scores (r = 0.011, P = 0.975). However, an inverse correlation was observed between changes in lactoferrin levels and the executive function subscale of the BACS (r = -0.360, P = 0.050). Cognitive assessments indicated significant improvements in verbal memory (P = 0.033), working memory (P = 0.002), and executive function (P = 0.039) post-treatment.
Conclusion: The study demonstrates a significant reduction in serum lactoferrin levels during the acute phase of schizophrenia, suggesting its potential role in modulating cognitive functions, particularly the executive function, rather than influencing positive or negative symptoms.
Role of Melatonin as an Adjunctive Treatment for Depression and Cognitive Impairment in Hemodialysis Patients: A Randomized, Double-Blind Clinical Trial
Authors: Hatamkhani Shima , Roshan Sepideh , Shiva Afshin
Published: December 2024

Objective: Chronic kidney disease (CKD) is a pervasive health issue associated with various complications, including cognitive impairment and depression among patients undergoing hemodialysis. This study aimed to assess the impact of melatonin on depression and cognitive function in hemodialysis patients.
Method: A randomized, double-blinded, placebo-controlled clinical trial was conducted in 50 hemodialysis patients, with half of the patients receiving 3 mg daily melatonin and the other half receiving a placebo for two months. Depression and cognitive function were evaluated using the Beck Depression Inventory (BDI) and Mini-Mental State Examination (MMSE) questionnaire, respectively. Quantitative variables were analyzed using a t-test. The Chi-square test also evaluated qualitative variables. Quantitative data were analyzed by covariance analysis before and after the intervention.
Results: Hypertension was the most prevalent underlying condition among study participants, affecting 40% of the intervention group. The intervention group exhibited baseline depressive symptoms (mean BDI score: 16.12 ± 7.12), which significantly improved post-intervention (13.6 ± 6.6). Notably, both the intervention and control groups demonstrated significant reductions in depressive symptoms, as assessed by paired t-tests (P = 0.033 and P = 0.02, respectively). Cognitive function, as measured by the MMSE, improved in both groups (1.28 ± 0.81 for melatonin, 1.52 ± 0.1 for placebo), with significant within-group differences (P = 0.048 and P = 0.002, respectively). ANCOVA analysis revealed no significant between-group differences in BDI scores (F(1,47) = 0.196, P = 0.66, partial eta-squared = 0.004). and in MMSE scores (F(1,47) = 0.003, P = 0.954, partial eta-squared = 0.00) post-intervention.
Conclusion: While this study did not demonstrate significant effects of melatonin on depression and cognitive impairment in hemodialysis patients, positive changes were observed, warranting further research to optimize treatment regimens and explore the potential therapeutic benefits of melatonin in this patient population.
Applications of Behavioral Economics and Neuroeconomics in Mental Health
Authors: Abdullaeva Barno Sayfutdinovna , Abdullaev Diyorjon , Djuraeva Laylo , Sagdullaeva Dilfuza Karimullaevna , Kholikov Azam
Published: December 2024

Objective: The integration of behavioral economics and neuroeconomics into mental health offers innovative perspectives on understanding and addressing psychological disorders. This overview aims to synthesize current knowledge and explore the implications of these interdisciplinary approaches in the context of mental health.
Method: In this narrative review, we summarized the current evidence regarding the applications of behavioral economics and neuroeconomics approaches in the field of mental health.
Results: Behavioral economics and neuroeconomics provide valuable insights into the cognitive and emotional processes underlying mental health disorders, such as irrational decision-making, impulsivity, and self-control issues. Concepts such as loss aversion, temporal discounting, and framing effects inform the development of innovative interventions and policy initiatives. Behavioral economic interventions, including nudges, incentives, and commitment devices, show promise in promoting treatment adherence, reducing risky behaviors, and enhancing mental well-being. Neuroeconomics contributes by identifying neural markers predictive of treatment response and relapse risk, paving the way for personalized treatment approaches.
Conclusion: The integration of behavioral economics and neuroeconomics into mental health research and practice holds significant potential for improving the understanding of psychological disorders and developing more effective, personalized interventions. Further research is needed to elucidate the mechanisms of action, optimize intervention strategies, and address ethical considerations associated with these approaches in mental health settings.
Neurocognitive Deficits in Individuals at Ultra-High-Risk for Psychosis: An Overview of Systematic Reviews
Authors: Asadiof Farnaz , Zamanpour Mona , Al-Hussainy Ali Fawzi , Al-Hassan Shalal Alhan Abd , Ubaid Mohammed , Aluquaily Zinab H. , Hashemian Seyed Hamidreza
Published: December 2024

Objective: Identifying individuals at ultra-high risk for psychosis (UHRP) is crucial for early intervention and prevention strategies. Neurocognitive deficits have been increasingly recognized as potential predictors of psychosis onset. This overview aims to consolidate current evidence and elucidate the role of neurocognitive predictors in identifying UHRP individuals.
Method: we systematically searched three scientific databases, i.e., PubMed, Scopus, and Google Scholar using predefined keywords related to predictive neurocognitive markers and ultra-high risk psychosis. By following the PRISMA procedure, we included all relevant systematic-reviews and meta-analyses in our data-synthesis.
Results: Neurocognitive deficits, including impairments in working memory, attentional control, verbal learning, and executive functions, have been consistently identified as predictors of psychosis conversion in individuals at UHRP. Structural and functional neuroimaging studies have further revealed aberrant brain connectivity, reduced gray matter volume, and altered neural activation patterns in key brain regions to be involved in psychosis. Moreover, the combination of neurocognitive and clinical risk factors has been shown to enhance the accuracy of predicting psychosis onset and inform personalized intervention strategies.
Conclusion: Neurocognitive deficits serve as valuable predictors of the risk of psychosis in individuals with UHRP, offering insights into the underlying neurobiological mechanisms and potential targets for early intervention. Future research should focus on refining predictive models, elucidating the neurodevelopmental trajectories, and evaluating the efficacy of targeted interventions in mitigating the psychosis risk.
A Meta-Analysis of the Structural Validity of Original and Brief Versions of the Personality Inventory for DSM-5 in Iran
Authors: Komasi Saeid , Kerber Andre , Hopwood Christopher James
Published: December 2024

Objective: The Personality Inventory for DSM-5 (PID-5) is a widely used scale to evaluate the dimensional constructs of two trait models proposed by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and the International Classification of Diseases (ICD-11). The present meta-analysis first aimed to examine the factor structure, reliability, and congruence coefficients of the Persian version of the PID-5 to assess both trait models. The second aim was to evaluate the factor structure and reliability of the Persian version of the Personality Inventory for DSM-5-Brief Form (PID-5-BF).
Method: A systematic search was conducted in PubMed, Magiran, and SID to find records in English and Farsi from January 2013 to December 2023. According to the PRISMA, data from nine medium- to high-quality reports including 7,608 participants were analyzed using the random-effects method. Quality of studies, heterogeneity, and publication bias were reported.
Results: The five-factor structure of the PID-5 to measure both trait models was supported by the pooled estimates of factor loadings. The alpha coefficient median for the DSM-5 model was 0.83 (range: 0.82-0.90), and the congruence coefficient median was .91 (range: 0.80-0.97). The ICD-11 alpha median was .78 (range: 0.68-0.91), and congruency median was 0.90 (range: 0.71-0.96). The factor loadings for negative affectivity, detachment, antagonism, disinhibition, and psychoticism on the PID-5-BF were 0.44-0.69, 0.38-0.67, 0.46-0.72, 0.42-0.70, and 0.44-0.76, respectively, and the alpha median was 0.73 (range: 0.65-0.76).
Conclusion: Since both the original and brief versions of the PID-5 are valid and strongly similar to international structures, the clinical and research applications of these questionnaires are recommended to mental health professionals in Iran.
Potential Antidepressant Effects of Omeprazole Introduced through Network Analysis and Systems Biology Should Be Interpreted with Caution in the Clinical Environment
Authors: Mostafavi Seyed-Ali
Published: December 2024

The Article Abstract is not available.
Depression and Anxiety as Potential Risk Factors for Tuberculosis
Authors: Allah Kalteh Ehsan , Mirzaei Masoud , Shokoufamanesh Ayuob , Akhondi Hossein , Izadi Shahin
Published: December 2024

The Article Abstract is not Available.
A Global Systematic Review of Factors Affecting the Biological Treatment of Wastewater Containing Petroleum Substances
Authors: Zarghi Mohammad Hasan , Javid Allahbakhsh , Sadighara Parisa , Khorasgani Fazlollah Changani
Published: December 2024

Introduction: A variety of treatment methods, including biological remediation, have been employed to address oil-contaminated wastewater. Bioremediation, which involves using microorganisms to mitigate or eliminate pollutants, is recognized as an environmentally friendly, cost-effective, and evolving technique for removing and breaking down various environmental contaminants, including those from oil industry.
Materials and Methods: This systematic review not only introduces biological treatment but also explores factors contributing to its success. In this study, a search was performed with keywords including petroleum substances, bioremediation, and biological treatment on Scopus, ScienceDirect, Web of Science, and PubMed, and 1349 studies were obtained, and 61 articles were finally chosen according to exclusion and inclusion criteria.
Results: A significant increase was observed in research articles over the past five years, likely reflecting the growing awareness of the need to remediate petroleum pollution in recent years. The nature of petroleum wastewater varies depending on the specific crude oil refining process, and factors that have the greatest effect on biological treatment include temperature, pH, inhibitors, time, oxygen, nutrients, nature, concentration of pollutants, and microorganism type. No single species of microorganism can break down all petroleum compounds.
Conclusion: This study allows decision-makers to evaluate these factors before implementing and investing in this method, ensuring its effectiveness in reducing petroleum pollution concentrations.
Comparison of Extremely Low Frequency Electromagnetic Waves in Different Parts of Residential Houses in Yazd City
Authors: Banadkooki Negar Zare , Madvari Rohollah Fallah , Jambarsang Sara , Teimouri Fahimeh , Haghighi Javad Rabi
Published: December 2024

Introduction: Extremely low frequency (ELF) waves are less than 300 Hz. Electrical devices with city electricity are one of the most important sources of generating ELF waves. The main objective of this research was to investigate and compare the magnetic fields produced by ELF electromagnetic fields (ELF-EMF) waves in different parts of residential houses in Yazd city.
Material and Methods: Thirty-three houses were selected, and an EMF-828 was used (made in Taiwan) for ELF-EMF intensity measurement in three parts of the kitchen, living room, and bedroom and three modes of Normal, OFF, and ON electrical instruments.
Results: Two-way ANOVA was used to compare two-by-two ELF waves in three modes: OFF, Normal, and ON. A significant value was obtained (p-value=0.036) in OFF and ON modes in the living room. Similar results were for kitchen (p-value=0.014) in two modes of ON and OFF. However, there was not a significant relationship (p>0.05) between the mean intensity of ELF-EMF waves and the studied building parameters.
Conclusion: The mean intensity of the ELF waves in different modes was not the same in kitchen and was in the order of ON> Normal> OFF that could be related to high-wave generation equipment. The comparison of mean intensity ​​of ELF-EMF waves in different locations of the investigated houses was much lower than the standard level set by ICNIRP. Preventing the simultaneous use of high-power electrical instruments led to both save consumption and reduce EMF-ELF waves exposure risk.
Examining Effective Strategies for Improving Sexual Satisfaction in Women during Pregnancy and Postpartum: A Review Study
Authors: Rahimi Farzaneh , Moenimehr Mahshid , Slam Fariba
Published: December 2024

Introduction: The period of pregnancy and postpartum is characterized by physical and psychological changes in women, which can significantly contribute to the onset or exacerbation of sexual disorders. Various nursing and midwifery interventions have been used as alternative therapeutic methods to improve sexual satisfaction in women during pregnancy and after childbirth, and this study aims to review and summarize these interventions.
Methods: A total of 40 studies (13 Persian articles and 27 Latin articles) have been examined. Nine distinct approaches have been utilized to enhance sexual satisfaction during pregnancy (17 studies) and following childbirth (23 studies). The influence of educational techniques for mothers across various areas (14 studies) during pregnancy, along with group and sexual counseling (10 studies) and group and sexual counseling (10 studies) and instruction on pelvic and leg exercises (9 studies) in the postpartum phase, appears to be more prevalent than other approaches in the research.  is more frequent than other methods in the studies. Researchers have conducted an investigation. .
Results: Uncoordinated movement was noted in 75% of mice following prolonged acetaminophen use (p<0.01) while pretreatment with Stevia entirely counteracted the effects of acetaminophen. Acetaminophen was significantly (p<0.01) increased serum AST and ALT and Sativa extract dose dependently mitigated the effects of acetaminophen. Pretreatment with both doses of stevia leads to a decrease in symptoms of liver necrosis caused by chronic acetaminophen use.
 
Conclusion: The approach of educating mothers in different areas, including sexual counseling and pelvic and Kegel exercise, is effective during pregnancy and post-delivery by midwifery professionals in the centers due to simplicity, accessibility, and affordability. Offering services and clinics have been utilized to enhance sexual satisfaction and improve the quality of women's sexual experiences, helping them better adjust to their pregnancy and postpartum periods.
Frequency and Causes of Dental Complaints in the Yazd Medical Council Organization between 2017 and 2022
Authors: Sabaghzadegan Yasaman , Amini-Bahabadi Sina , Owlia Fatemeh
Published: December 2024

Introduction: Currently, even with the extensive and advanced resources available in dentistry, patient dissatisfaction and complaints have increasingly become more prevalent. To acquire accurate and practical data for enhancing dental services’ quality and reducing the expenses linked to complaints, research must be performed to explore dental grievances. This research sought to identify the rate and reasons behind complaints made against dentists to the healthcare system from 2017 to 2022.  Methods: This cross-sectional research entailed gathering existing data and examining complaint records from dentists at the Yazd Medical Council Organization. The information was gathered through observation and by filling out applicable checklists. Subsequently, thedata underwent analysis through  SPSS version 16, utilizing with a chi-square test and Spearman correlation. The threshold for statistical significance was established at p≤ 0.05.
Results: According to the results obtained, the majority of complaints were directed towards general dentists, especially males. Over fifty percent of the individuals who filed complaints were female. The most frequent types of dental issues were associated with surgery, endodontic, and prosthetic care. In 52.9 percent of the cases, dentists were deemed guilty, primarily due to complaints related to malpractice.
Conclusion: Dental practitioners must increase their knowledge regarding case selection and dental management to improve their practice.
Immunohistochemical Study of Expression of Cyclynd1 Expression in Invasive and Non-invasive Odontogenic Cysts
Authors: Jafari Najmeh , Tabatabaei Seyed Hosein , Karimi Raheleh
Published: December 2024

Introduction: A radicular cyst is an inflammatory cyst arising from the remnants of epithelial malassez, while the Dentigerus cyst is linked to the impacted crown. The odontogenic Keratocyst is a developmental cyst that exhibits suggesting invasive behavior and a propensity to adjacent tissues, potentially due to the proliferation of the epithelial lining or the enzymatic composition of the cyst wall. CyclynD1 is a protein in the Rb pathway that regulates the shift from G1 to S phase. This protein can enable the cell to bypass cell cycle checkpoints and is crucial in lesion development. Considering the varied outcomes and limited research on the expression of the aforementioned marker in odontogenic cysts ، the aim of this study was to compare odontogenic keratocysts (OKC) with two types of non-invasive inflammatory and growth-developmental cysts.
Methods: Following a review of the patient records from the Pathology Department of Dental School of Yazd for all jaw cysts، 15 blocks from each of the three cyst types with adequate tissue were chosen for immunohistochemical staining using the Cyclin D1 marker. The stained cell count under a light microscope at x400 magnification was performed and the findings were analyzed using SPSS16 software utilizing Mann-Whitney and Kruskal-Wallis tests.
Results: There was no statistically significant difference observed among the three cysts regarding epithelial coverage (p = 0.226) and connective tissue (P = 0.578).
Conclusion: Based on the findings of this study، the high expression of this marker in odontogenic Keratocyst may signify its involvement in the pathogenesis and progression of this cyst in contrast to other cysts.