bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Indian Music as an Auditory Stimulus on Physiological Measures of Stress, Anxiety, Cardiovascular and Autonomic Responses in Humans—A Randomized Controlled Trial
Authors: Kunikullaya Ubrangala Kirthana , Kunnavil Radhika , Sanjeeva Vernekar Mamta , Goturu Jaisri , Vijayadas  , Prakash V. S. , Murthy Nandagudi Srinivasa
Published: October 2022

Among the different anthropogenic stimuli humans are exposed to, the psychological and cardiovascular effects of auditory stimuli are less understood. This study aims to explore the possible range of change after a single session of auditory stimulation with three different ‘Modes’ of musical stimuli (MS) on anxiety, biomarkers of stress, and cardiovascular parameters among healthy young individuals. In this randomized control trial, 140 healthy young adults, aged 18–30 years, were randomly assigned to three MS groups (Mode/Raga Miyan ki Todi, Malkauns, and Puriya) and one control group (natural sounds). The outcome measurements of the State-Trait Anxiety Inventory, salivary alpha-amylase (sAA), salivary cortisol (sCort), blood pressure, and heart rate variability (HRV) were collected at three time points: before (M1), during (M2), and after the intervention (M3). State anxiety was reduced significantly with raga Puriya (p = 0.018), followed by raga Malkauns and raga Miyan Ki Todi. All the groups showed a significant reduction in sAA. Raga Miyan ki Todi and Puriya caused an arousal effect (as evidenced by HRV) during the intervention and significant relaxation after the intervention (both p < 0.005). Raga Malkauns and the control group had a sustained rise in parasympathetic activity over 30 min. Future studies should try to use other modes and features to develop a better scientific foundation for the use of Indian music in medicine.
Joint Optimization Method of Spectrum Resource for UAV Swarm Information Transmission
Authors: Wu Di , Zhang Yu , Chen Yong
Published: October 2022

For the problems brought by malicious interference in the unmanned aerial vehicle (UAV) swarm network, we establish a cluster-based UAV swarm information transmission model. We mainly consider four aspects: cluster head selection, channel allocation, power allocation and UAV position. In order to improve the backhaul information rate of UAV swarm, we propose a joint optimization method of spectrum resource with the goal of maximizing the sum throughput of the cluster head UAV. We decompose the original mixed integer nonlinear programming (MINLP) problem into multiple sub-problems based on the block coordinate descent (BCD) technique, and then solve them based on convex optimization and successive convex approximation (SCA) technique. Simulation results show that the proposed method can obtain the spectrum resource optimization strategy of UAV swarm information transmission, reduce the impact of malicious interference, and effectively improve the backhaul information rate of UAV swarm.
Discussion on the Feasibility of Deep Peak Regulation for Ultra-Supercritical Circulating Fluidized Bed Boiler
Authors: Xin Shengwei , Wang Hu , Li Jianbo , Wang Gang , Wang Quanhai , Cao Peiqing , Zhang Peng , Lu Xiaofeng
Published: October 2022

In order to meet the flexibility operation needs of coal-fired units under the goal of carbon peak and carbon neutralization, it is imperative for circulating fluidized bed (CFB) units to participate in deep peak regulation. By systematically summarizing deep peak regulation operation practice of existing SC and subcritical-parameter-levels CFB units, the feasibility of deep peak regulation technology of an ultra-supercritical (USC) CFB unit under development and being built is analyzed and demonstrated; meanwhile, the deep peak regulation capacity of the boiler is also predicted. The results show that by analyzing the structural characteristics and design performance of the USC-CFB boiler, for technical problems such as stable combustion under low load, hydrodynamic safety, denitration performance under wide load, and rapid boiler load change rate existing in deep peak regulation, technical measures were implemented by selecting advanced boiler furnace type, adopting good design technology of the secondary rising water wall and uniformity design of bed temperature and bed pressure, strengthening the reducing atmosphere inside the furnace, improving the performance of wear-resistant refractory materials, quickly controlling the furnace bed material stock under variable load, optimizing the control strategy of CFB unit, and so on. The boiler achieved good operation characteristics and good deep peak regulation performance, and the pollutant emissions can steadily achieve ultra-low emission standards. When the USC-CFB unit participates in deep peak regulation, the minimum stable combustion load of the boiler can reach 20~30% BMCR, and a boiler load change rate under 30% BMCR or above could reach 1.5~2% BMCR/min, while that below 30% BMCR could reach 1% BMCR/min. The research results can provide references for the deep peak regulation of in-service supercritical (SC) CFB units and design optimization of similar USC-CFB units.
Synergetic Effect of Non-Condensable Gas and Steam Quality on the Production Capacity of Geothermal Wells and Geothermal Power Generation for Hot Dry Rock
Authors: Li Tailu , Gao Ruizhao , Gao Xiang , Liu Qinghua
Published: October 2022

This paper aims to fill the research gap on the effect of steam quality and non-condensable gas on heat-carrying fluid productivity, system performance and optimization. First, the effect of the temperature and quality of the heat-carrying fluid and non-condensable gas (NCG) content on the production parameters was evaluated. After that, three energy conversion systems which included a single flash (SF) system, an organic Rankine cycle (ORC) system and a single flash combined ORC (SFORC) system were constructed in this paper to utilize the heat-carrying two-phase flow with non-condensable gas. Finally, based on thermodynamic modeling, the effects of the temperature and quality of the heat-carrying fluid and non-condensable gas content on the performance and optimization of the three power conversion systems were investigated. The results show that single-phase heat-carrying fluids are more productive than two-phase heat-carrying fluids. NCG is always detrimental. The heat-carrying fluid temperature and quality are positively correlated with system efficiency and negatively correlated with the net power output. In the comparison of comprehensive performances, the SFORC system is the better, and the ORC system and the SF system are the worse. The optimal net power output of the SF system, the ORC system and the SFORC system is 4883 kW, 6557 kW and 7251 kW, respectively.
Partial Discharge Characteristics of C3F7CN Gas Mixture Using the UHF Method
Authors: Loizou Loizos , Han Qinghua , Chen Lujia , Liu Qiang , Waldron Mark , Wilson Gordon , Bautista Roberto Fernandez , Seltzer-Grant Malcolm
Published: October 2022

Manufacturing or assembly defects in gas-insulated equipment can introduce field enhancements that could lead to partial discharge (PD). This paper examines the PD characteristics of SF6 alternatives considered for potential application to retro-filling existing SF6-designed equipment. The PD performance of the C3F7CN/CO2 gas mixture and SF6 were characterised adopting the ultra-high frequency (UHF) method and investigated for different defect configurations, pressures, and gas mediums. Hemispherical rod-plane and plane-to-plane configurations with needle on the high-voltage (HV) and ground electrodes were used to mimic conductor and enclosure protrusion defects, respectively. The results demonstrate that with a needle length of 15 mm, the 20% C3F7CN/80% CO2 gas mixture had almost half the partial discharge inception and extinction voltages (PDIV/EV) of SF6. For less divergent fields, the 20% C3F7CN/80% CO2 gas mixture demonstrated a comparable PDIV/EV performance as SF6. The phase-resolved PD patterns of the 20% C3F7CN/80% CO2 gas mixture demonstrated a 3-stage transition phase that was not observed with SF6, which could be due to the discharge mechanism of the weakly attaching CO2 gas used within the mixture.
Optimal Load Distribution of CHP Based on Combined Deep Learning and Genetic Algorithm
Authors: Wan Anping , Chang Qing , Zhang Yinlong , Wei Chao , Agbozo Reuben Seyram Komla , Zhao Xiaoliang
Published: October 2022

In an effort to address the load adjustment time in the thermal and electrical load distribution of thermal power plant units, we propose an optimal load distribution method based on load prediction among multiple units in thermal power plants. The proposed method utilizes optimization by attention to fine-tune a deep convolutional long-short-term memory network (CNN-LSTM-A) model for accurately predicting the heat supply load of two 30 MW extraction back pressure units. First, the inherent relationship between the heat supply load and thermal power plant unit parameters is qualitatively analyzed, and the influencing factors of the power load are screened based on a data-driven analysis. Then, a mathematical model for load distribution optimization is established by analyzing and fitting the unit’s energy consumption characteristic curves on the boiler and turbine sides. Subsequently, by using a randomly chosen operating point as an example, a genetic algorithm is used to optimize the distribution of thermal and electrical loads among the units. The results showed that the combined deep learning model has a high prediction accuracy, with a mean absolute percentage error (MAPE) of less than 1.3%. By predicting heat supply load variations, the preparedness for load adjustments is done in advance. At the same time, this helps reduce the real-time load adjustment response time while enhancing the unit load’s overall competitiveness. After that, the genetic algorithm optimizes the load distribution, and the overall steam consumption rate from power generation on the turbine side is reduced by 0.488 t/MWh. Consequently, the coal consumption rate of steam generation on the boiler side decreases by 0.197 kg (coal)/t (steam). These described changes can greatly increase the power plant’s revenue by CNY 6.2673 million per year. The thermal power plant used in this case study is in Zhejiang Province, China.
Smart Energy Management Strategy for Microgrids Powered by Heterogeneous Energy Sources and Electric Vehicles’ Storage
Authors: Madhavaram Poornachandra Reddy , M Manimozhi
Published: October 2022

The rapid growths of power demand and renewable resources have led to numerous challenges. Constructing more resilient microgrids (MGs) provides an opportunity to avoid dependency on the main grid. This article proposes an innovative Energy Management Strategy (EMS) for microgrids that uses non-conventional energy sources such as solar power, wind power, and the storage of electric vehicles (EVs). Numerous studies have been published on MG EMSs using storage; however, in real-time scenarios, predominant factors limit their straightforward implementation. In this article, an attempt is made to address key aspects of EV storage exploitation to support MGEMSs. Minimizing the total MG energy cost is the key objective, considering EV battery longevity and technical limitations. The proposed EMS was implemented in three layers: Optimal Storage Distribution (OSD), Optimal Power Usage (OPU), and EV Selection (EVS). A novel probabilistic approach was implemented in the EVS process (using a Fuzzy Logic Controller (FLC)) to minimize battery degradation. Various case studies were analyzed in a grid-connected MG by implementing the proposed EMS.
Transport Sustainability Index: An Application Multicriteria Analysis
Authors: de Freitas Rodrigo Rodrigues , Caetano Joyce Azevedo , de Oliveira Cintia Machado , do Carmo Amorim Felipe , da Silva Marcio Antelio Neves
Published: October 2022

The unrestricted consumption of fossil fuels negatively impacts the economic, social and environmental aspects, observed from a sustainable perspective. Therefore, it is necessary to develop and adopt skills that enable the monitoring and mitigation of risks to the environment. In view of this, we propose a method with multiple approaches emphasizing a three-dimensional perspective of energy consumption by diesel engines, which represent one of the main pollutants emitters in transport. As a methodology, fuzzy logic was adopted, together with a recognition system, in order to mitigate the uncertainties inherent to the applied data. The procedure was applied to the city of Rio de Janeiro, Brazil, with information collected from seven toll plazas and a radar with volumetric counting. The results indicate a good adherence of the sustainability index to real cases, allowing a better observation of changes in environmental criteria and a more efficient inspection in the application of good practices, in addition to enabling greater participation of society in the inspection and adoption of environmental criteria in transport.
Population Structure of Wild Schizothorax kozlovi in the Upper Yangtze River Based on mtDNA and Stable Isotopes, and Their Relationship with Ambient Temperature
Authors: He Yongfeng , Gong Jinling , Wu Xingbing , Zhu Yongjiu , Yang Deguo
Published: October 2022

Schizothorax kozlovi, as an endemic and vulnerable fish of the upper Yangtze River in China, faces many threats. In order to expose the population structure of wild S. kozlovi, the carbon and oxygen isotopic ratios in the otoliths, and the gene sequences of two common mitochondrial markers (Cytb and COI) were investigated in four sampling locations, and then their relationship with ambient temperature was further investigated. In general, it exhibits limited geographic population structuring of S. kozlovi in the upper Yangtze River by both mtDNA and stable isotopes. The values of otolith stable isotope ratios varied from −15.30‰ to −12.37‰ for δ18O and from −10.10‰ to −6.13‰ for δ13C. Significant relationships were revealed between stable isotope ratios and specific mean monthly water temperature variables (from November to March), indicating low temperature effect on otolith stable isotope ratios. Haplotype diversity and nucleotide diversity were 0.928 and 0.00778, both exhibiting high levels. A median-joining haplotype network indicated a mixture of geographical distribution but exhibited two distinct haplotype lineages (Clade I and Clade II). AMOVA detected that the higher percentage of genetic variance was within sampling locations (96.94%) and between two haplotype lineages (72.82%). Most FST values between sampling locations showed small levels of genetic differentiation except the differentiation between population SJ (Sanjiangkou) and JP (Jinping). Therefore, two haplotype lineages and population JP of S. kozlovi in the upper Yangtze River are suggested as three management units for conservation due to their moderate-to-great genetic differentiation and isolated habitat.
Shelter Color Selection of Juvenile Swimming Crabs (Portunus trituberculatus)
Authors: Zhang Hanzun , Zhu Boshan , Yu Liye , Wang Fang
Published: October 2022

Color preference testing for animals is a prerequisite for optimizing facilities and ensuring animal welfare in aquaculture. Swimming crabs (Portunus trituberculatus) are aggressive, and shelters are often installed in ponds to reduce the high mortality rate caused by their agonistic behavior. To test the preference of juvenile crabs for the color of shelters, this study observes the preferences of crabs for shelters of different colors (white, yellow, blue, and black). The counts and duration of crabs occupying different colored shelters were quantified. The probability of fighting and the probability of abandoning the shelter were also calculated. The results revealed that: (i) when all colors were presented simultaneously, the z-scores of the blue shelters were far higher than others during the day; (ii) when only one color was present, crabs occupied the blue shelter significantly more often and for longer periods of time than others during the day, with invasive crabs exacerbating this preference; and (iii) the probability of fighting between crabs was relatively low in the presence of the blue shelter, and the probability of abandoning the shelter was significantly lower than that of others. Based on these results, blue shelters are recommended for use in swimming crab ponds.
Foundations of Electromagnetism: A Review of Wilhelm Weber’s Electrodynamic Force Law
Authors: Baumgärtel Christof , Maher Simon
Published: October 2022

This article reviews the electrodynamic force law of Wilhelm Weber and its importance in electromagnetic theory. An introduction is given to Weber’s force and it is shown how it has been utilised in the literature to explain electromagnetism as well as phenomena in other disciplines of physics, where the force law has connections to the nuclear force, gravity, cosmology, inertia and quantum mechanics. Further, criticism of Weber’s force is reviewed and common misconceptions addressed and rectified. It is found that, while the theory is not without criticism and has much room for improvement, within the limitations of its validity, it is equally as successful as Maxwell’s theory in predicting certain phenomena. Moreover, it is discussed how Weber offers a valid alternative explanation of electromagnetic phenomena which can enrich and complement the field perspective of electromagnetism through a particle based approach.
Construction of Optimal Split-Plot Designs for Various Design Scenarios
Authors: Han Beichen , Zhao Yuna
Published: October 2022

When performing fractional factorial experiments in a completely random order is impractical, fractional factorial split-plot designs are suitable options as an alternative. It is well recognized that the more there are lower order effects of interest at lower order confounding, the better the designs. From this viewpoint, this paper considers the construction of optimal regular two-level fractional factorial split-plot designs. The optimality criteria for two different design scenarios are proposed. Under the newly proposed optimality criteria, the theoretical construction methods of optimal regular two-level fractional factorial split-plot designs are then proposed. In addition, we also explore the theoretical construction methods of some optimal regular two-level fractional factorial split-plot designs under the widely adopted general minimum lower order confounding criterion.
Strength Analysis of Cement Mortar with Carbon Nanotube Dispersion Based on Fractal Dimension of Pore Structure
Authors: Guo Jinjun , Yan Yanling , Wang Juan , Xu Yaoqun
Published: October 2022

Carbon nanotubes (CNTs) are considered among the ideal modifiers for cement-based materials. This is because CNTs can be used as a microfiber to compensate for the insufficient toughness of the cement matrix. However, the full dispersion of CNTs in cement paste is difficult to achieve, and the strength of cement material can be severely degraded by the high air-entraining property of CNT dispersion. To analyze the relationship between the gas entrainment by CNT dispersion and mortar strength, this study employed data obtained from strength and micropore structure tests of CNT dispersion-modified mortar. The fractal dimensions of the pore volume and pore surface, as well as the box-counting dimension of the pore structure, were determined according to the box-counting dimension method and Menger sponge model. The relationship between the fractal dimensions of the pore structure and mortar strength was investigated by gray correlation. The results showed that the complexity of the pore structure could be accurately reflected by fractal dimensions. The porosity values of mortar with 0.05% and 0.5% CNT content were 15.5% and 43.26%, respectively. Moreover, the gray correlation between the fractal dimension of the pore structure and strength of the CNT dispersion-modified mortar exceeded 0.95. This indicated that the pore volume distribution, roughness, and irregularity of the pore inner surface were the primary factors influencing the strength of CNT dispersion-modified mortar.
Systems of Riemann–Liouville Fractional Differential Equations with ρ-Laplacian Operators and Nonlocal Coupled Boundary Conditions
Authors: Tudorache Alexandru , Luca Rodica
Published: October 2022

In this paper, we study the existence of positive solutions for a system of fractional differential equations with ρ-Laplacian operators, Riemann–Liouville derivatives of diverse orders and general nonlinearities which depend on several fractional integrals of differing orders, supplemented with nonlocal coupled boundary conditions containing Riemann–Stieltjes integrals and varied fractional derivatives. The nonlinearities from the system are continuous nonnegative functions and they can be singular in the time variable. We write equivalently this problem as a system of integral equations, and then we associate an operator for which we are looking for its fixed points. The main results are based on the Guo–Krasnosel’skii fixed point theorem of cone expansion and compression of norm type.
A Participatory Framework for Plain Language Clinical Management Guideline Development
Authors: Francisco Rita , Alves Susana , Gomes Catarina , Granjo Pedro , Pascoal Carlota , Brasil Sandra , Neves Alice , Santos Inês , Miller Andrea , Krasnewich Donna , Morava Eva , Lam Christina , Jaeken Jaak , Videira Paula A. , dos Reis Ferreira Vanessa
Published: October 2022

Background: Clinical management guidelines (CMGs) are decision support tools for patient care used by professionals, patients, and family caregivers. Since clinical experts develop numerous CMGs, their technical language hinders comprehension and access by nonmedical stakeholders. Additionally, the views of affected individuals and their families are often not incorporated into treatment guidelines. We developed an adequate methodology for addressing the needs and preferences of family and professional stakeholders regarding CMGs, a recently developed protocol for managing congenital disorders of glycosylation (CDG), a family of rare metabolic diseases. We used the CDG community and phosphomannomutase 2 (PMM2)-CDG CMGs as a pilot to test and implement our methodology. Results: We listened to 89 PMM2-CDG families and 35 professional stakeholders and quantified their CMG-related needs and preferences through an electronic questionnaire. Most families and professionals rated CMGs as relevant (86.5% and 94.3%, respectively), and valuable (84.3% and 94.3%, respectively) in CDG management. The most identified challenges were the lack of CMG awareness (50.6% of families) and the lack of plain language CMG (39.3% of professionals). Concordantly, among families, the most suggested solution was involving them in CMG development (55.1%), while professionals proposed adapting CMGs to include plain language (71.4%). Based on these results, a participatory framework built upon health literacy principles was created to improve CMG comprehension and accessibility. The outputs are six complementary CMG-related resources differentially adapted to the CDG community’s needs and preferences, with a plain language PMM2-CDG CMG as the primary outcome. Additionally, the participants established a distribution plan to ensure wider access to all resources. Conclusions: This empowering, people-centric methodology accelerates CMG development and accessibility to all stakeholders, ultimately improving the quality of life of individuals living with a specific condition and raising the possibility of application to other clinical guidelines.
Health-Related Expectations Regarding Aging among Middle-Aged and Older Japanese: Psychometric Performance and Novel Findings from the ERA-12-J
Authors: Annear Michael , Shimizu Yasuo , Kidokoro Tetsuhiro
Published: October 2022

Background and objectives: Health-related expectations regarding aging is a gerontological construct that is potentially predictive of morbidity and mortality in later life. The Expectations Regarding Ageing scale (ERA-12) is a widely used measure of health-related expectations, although it has not previously been administered in Japanese. The present research aimed to elucidate the psychometric properties of the first Japanese translation of the ERA-12 and evaluate health-related expectations among middle-aged and older Japanese. Research design and methods: Repeated online surveys were conducted with representative quota samples of middle-aged and older adults in Tokyo during 2021 (N = 1600). Primary outcome measures included total and subscale scores on a Japanese translation of the ERA-12 (ERA-12-J) addressing perceptions of physical, mental, and cognitive health. Standard measures were also used to gather information regarding respondent demographic details, general health, and health-related behavior. Results: The ERA-12-J and associated subscales showed acceptable test-retest reliability (t(1598) = 0.60, p = 0.63), internal consistency (α > 0.80), inter-item correlation (r = 0.21–0.78) and item-total correlation (r = 0.53–0.73). Confirmatory Factor Analysis verified the hypothesized three-factor structure and construct validity on four common indices of fit (GFI = 0.968; CFI = 0.978; AGFI = 0.950; RMSEA = 0.059). ERA-12-J scores among Japanese respondents revealed prevailing negative sentiments concerning physical and cognitive health, with less negative sentiment regarding mental health. Significant and independent differences emerged concerning gender and age cohort, with middle-aged adults and females holding more negative expectations about their future health. Discussion and implications: The ERA-12-J provides a sound basis for the elucidation of health-related expectations about aging in Japan and a useful tool for international comparative studies. Education and workplace intervention may be required in Japan to address age and gender disparities in health-related expectations.
Optimization of Emission Reduction Target in the Beijing–Tianjin–Hebei Region: An Atmospheric Transfer Coefficient Matrix Perspective
Authors: Wang Yuan , Pan Zhou , Li Yue , Lu Yaling , Dong Yiming , Ping Liying
Published: October 2022

In recent years, the problem of atmospheric pollution has been concerning in the Beijing–Tianjin–Hebei region, due to the frequent haze. It has become a significant issue to improve regional air quality through appropriate emission reduction measures. In this study, considering the regional atmospheric transmission of air pollutants, the WRF/CALPUFF model (the Weather Research and Forecasting model coupled with the California Puff air quality model) was used to describe the impact of each city’s pollutant emissions on the concentrations of every city. Then, a new optimization model was designed to calculate the maximum allowable emissions of every city. The results showed that NOx and PM2.5 emissions need to be reduced by 44% and 48%, respectively, in the traditional mitigation scenario (any city’s pollutant emissions are not allowed to increase). However, in the optimized scenario, NOx and PM2.5 emissions should be reduced by 23% and 46%, respectively, to meet the national secondary standard. The emissions of cities with low transfer coefficients, such as Zhangjiakou, Qinhuangdao, and Chengde, could even be appropriately increased. This means that the optimized scenario could reduce the pressure on emission reduction. Although the optimization results are theoretical and idealistic, this research study provides a new idea for formulating emission mitigation policies in various regions to reduce the impact on the economy.
“To Be Treated as a Person and Not as a Disease Entity”—Expectations of People with Visual Impairments towards Primary Healthcare: Results of the Mixed-Method Survey in Poland
Authors: Binder-Olibrowska Katarzyna Weronika , Godycki-Ćwirko Maciek , Wrzesińska Magdalena Agnieszka
Published: October 2022

Primary care is the core part of the Polish healthcare system. Improving its quality for vulnerable populations is among the principal goals of global and national health policies. Identifying patients’ needs is critical in this process. People who are blind or have low vision often demonstrate comorbidities and require more specific healthcare. The aim of this study was to explore the needs of Polish persons with visual impairments when they use primary care services. 219 respondents answered the “Patient value” questionnaire from the project Quality and Costs of Primary Care in Europe (QUALICOPC) and an open question regarding additional patients’ needs. Statistical and content analyses were used. The expectations of the study group regarding primary care appeared to be higher than those described in studies among other populations. Equity and accessibility were the most valued dimensions of care. Among particular aspects of care, those connected with psychosocial competencies and awareness of disability among medical staff appeared most frequently. Some personal characteristics were associated with preferences, including age, gender, longstanding conditions, quality of life, and disability-related variables. Our study indicates a need for multilevel interventions in legislation, economics, and medical staff training, with the people-centered approach as the option maximizing chances to meet diverse healthcare needs arising from particular disabilities.
“I…Tell Her Not to Take Medicines”: Understanding Engagement in the Prevention of Mother to Child Transmission (PMTCT) Care Continuum through the Socio-Ecological Model
Authors: Modi Anjali , Garcia-Alcaraz Cristian , Trivedi Sangita , Kosambiya J. K. , Wells Kristen J.
Published: October 2022

With ten percent of the world’s children living with Human Immunodeficiency Virus (HIV/ AIDS) in India, achieving elimination of parent/mother to-child transmission (EPTCT/EMTCT) is far away. Timely initiation and optimal adherence to the prevention of parent/mother to child transmission (PPTCT/PMTCT) may reduce new paediatric HIV infections to zero. This qualitative study applies the Socio-ecological Model (SEM) to understand country, region and context-specific factors influencing mothers’ engagement in the PMTCT care continuum. Maximum variation sampling and saturation tenets determined the sample size. An in-depth interview guide based on SEM “a priori” and emerging themes captured narratives of the parental dyad. The translated and transcribed audio records were coded by direct content analysis method, both manually and with Atlas Ti software. The coding reports were discussed for consensus and final analysis. Male partner, peers, community health workers (CHWs), hope for healthy baby, knowledge about HIV and preventive services, free anti-retroviral therapy, transportation and the early infant diagnosis (EID) tool influenced PMTCT care continuum. Testing and referral policies of the private sector facilitated internalized or self-stigma. Future interventions should seek to develop pregnant women’s support system by engaging male partners, peers, and CHWs. Strategies addressing private sector and community awareness about freely available HIV prevention and care programs may enable optimal PMTCT utilization.
Stakeholders’ Perceptions Regarding Adaptation and Implementation of Existing Individual and Environmental Workplace Health Promotion Interventions in Blue-Collar Work Settings
Authors: Sponselee Hanne C. S. , ter Beek Lies , Renders Carry M. , Robroek Suzan J. W. , Steenhuis Ingrid H. M. , Kroeze Willemieke
Published: October 2022

Blue-collar workers often have disadvantageous health statuses and might therefore benefit from a combination of individual and environmental workplace health promotion interventions. Exploring stakeholders’ perceived facilitators and barriers regarding the combined implementation of these interventions in blue-collar work settings is important for effective implementation. A qualitative study consisting of 20 stakeholder interviews within six types of organisations in The Netherlands was conducted. The potential implementation of the evidence-based individual intervention SMARTsize and the environmental intervention company cafeteria 2.0 was discussed. Data were analysed using thematic analysis with a deductive approach. Five main themes emerged: (1) the availability of resources, (2) professional obligation, (3) expected employee cooperation, (4) the compatibility of the proposed health interventions, and (5) the content of implementation tools and procedures. Generally, stakeholders expressed a sense of professional obligation toward workplace health promotion, mentioning that the current societal focus on health and lifestyle provided the perfect opportunity to implement interventions to promote healthy eating and physical activity. However, they often perceived the high doses of employees’ occupational physical activity as a barrier. We recommend co-creating interventions, implementation tools, and processes by involving stakeholders with different professional backgrounds and by adapting communication strategies at diverse organisational levels.
Prevalence of Anxiety and Depression Symptoms and Their Relationship with Nutritional Status and Mortality in Patients with Colorectal Cancer
Authors: Soria-Utrilla Virginia , Sánchez-Torralvo Francisco José , González-Poveda Iván , Mera-Velasco Santiago , Porras Nuria , Toval-Mata José Antonio , García-Olivares María , Ruiz-López Manuel , Gonzalo-Marín Montserrat , Carrasco-Campos Joaquín , Tapia María José , Santoyo-Santoyo Julio , Olveira Gabriel
Published: October 2022

Background: Anxiety and depression are common in patients with cancer. The aim of this study is to determine the prevalence of anxiety and depression symptoms in colorectal cancer (CRC) patients awaiting elective surgery and whether there is an association with their preoperative nutritional status and postoperative mortality. Methods: A prospective study was conducted on 215 patients with CRC proposed for surgery. Data about nutritional status were collected using the Global Leadership Initiative on Malnutrition (GLIM) criteria, while anxiety and depression symptoms data were collected using Hospital Anxiety and Depression Scale (HADS). Results: HADS detected possible anxiety in 41.9% of patients, probable anxiety in 25.6%, possible depression in 21.9%, and probable depression in 7.9%. GLIM criteria found 116 (53.9%) patients with malnutrition. The HADS score for depression subscale was significantly higher in malnourished patients than in well-nourished (5.61 ± 3.65 vs. 3.95 ± 2.68; p = 0.001). After controlling for potential confounders, malnourished patients were 10.19 times more likely to present probable depression (95% CI 1.13–92.24; p = 0.039). Mortality was 1.9%, 4,2%, and 5.6% during admission and after 6 and 12 months, respectively. Compared to patients without depressive symptomatology, in patients with probable depression, mortality risk was 14.67 times greater (95% CI 1.54–140.21; p = 0.02) during admission and 6.62 times greater (95% CI 1.34–32.61; p = 0.02) after 6 months. Conclusions: The presence of anxiety and depression symptoms in CRC patients awaiting elective surgery is high. There is an association between depression symptoms, preoperative nutritional status, and postoperative mortality.
Correlations between Problematic Mobile Phone Use and Depressiveness and Daytime Sleepiness, as Well as Perceived Social Support in Adolescents
Authors: Nowak Marta , Rachubińska Kamila , Starczewska Małgorzata , Kupcewicz Ewa , Szylińska Aleksandra , Cymbaluk-Płoska Aneta , Grochans Elżbieta
Published: October 2022

(1) The aim of this study was to estimate the scale of mobile phone addiction among young adults as well as to establish whether the low level of perceived social support is related to problematic smartphone use, and whether an addictive pattern of mobile phone use is related to the prevalence of depressiveness and excessive daytime sleepiness. (2) The study was carried out using the diagnostic poll method via the questionnaire technique. Both the author’s own questionnaire and the following standardized research tools were used: the Mobile Phone Problem Use Scale for Adolescents (MPPUSA), the Beck Depression Inventory (BDI), the Epworth Sleepiness Scale (ESS), and the Multidimensional Scale of Perceived Social Support (MSPSS). (3) Perceived social support was significantly lower in the group of respondents who problematically used their mobile phones in comparison with the ones who used them in a proper way. Severity of depressive symptoms and daytime sleepiness was significantly higher in respondents addicted to their mobiles compared to nonaddicted ones. (4) Conclusions: An important correlation between phone addiction and the prevalence of depressive symptoms and excessive daytime sleepiness exists. Problematic mobile phone use concerns individuals with low levels of perceived social support.
A Cost-Utility Analysis of Mesh Prophylaxis in the Prevention of Incisional Hernias following Stoma Closure Surgery
Authors: Sheikh Yusuf , Asunramu Hareef , Low Heather , Gakhar Dev , Muthukumar Keerthi , Yassin Husam , de Preux Laure
Published: October 2022

Background: Stoma closure is a widely performed surgical procedure, with 6295 undertaken in England in 2018 alone. This procedure is associated with significant complications; incisional hernias are the most severe, occurring in 30% of patients. Complications place considerable financial burden on the NHS; hernia costs are estimated at GBP 114 million annually. As recent evidence (ROCSS, 2020) found that prophylactic meshes significantly reduce rates of incisional hernias following stoma closure surgery, an evaluation of this intervention vs. standard procedure is essential. Methods: A cost-utility analysis (CUA) was conducted using data from the ROCSS prospective multi-centre trial, which followed 790 patients, randomly assigned to mesh closure (n = 394) and standard closure (n = 396). Quality of life was assessed using mean EQ-5D-3L scores from the trial, and costs in GBP using UK-based sources over a 2-year time horizon. Results: The CUA yielded an incremental cost-effectiveness ratio (ICER) of GBP 128,356.25 per QALY. Additionally, three univariate sensitivity analyses were performed to test the robustness of the model. Conclusion: The results demonstrate an increased benefit with mesh prophylaxis, but at an increased cost. Although the intervention is cost-ineffective and greater than the ICER threshold of GBP 30,000/QALY (NICE), further investigation into mesh prophylaxis for at risk population groups is needed.
Changing the Office Design to Activity-Based Flexible Offices: A Longitudinal Study of How Managers’ Leadership Behaviours Are Perceived
Authors: Larsson Johan , Vinberg Stig , Jahncke Helena
Published: October 2022

This longitudinal study examines the impact of office type on employees’ perception of managers’ leadership behaviours, which is an unexplored area. The expanding research related to activity-based flexible offices (AFOs) has mainly focused on employees’ working conditions and health outcomes, not on the changes in leadership behaviours when moving from traditional offices to AFOs. Office workers (n = 261) from five office sites within a large Swedish government agency were included in a controlled study of a natural intervention. At four sites, traditional offices were replaced by AFOs, while workers at one site with no relocation acted as the control. The same employees rated different leadership behaviours in a web-based questionnaire at baseline and at one follow-up. The analyses showed that relocations from cell and open-plan offices to AFOs were clearly related to a decrease in the perception of relation-oriented leadership behaviours. However, coming from open-plan offices to AFOs also decreased the perception of the other leadership dimensions. As expected, the control group was stable over time in their perceptions. This emphasises the need for organisations to provide managers with prerequisites so they can keep up with behaviours that support employees’ performance and health when office designs and ways of working are changed.
The Relationship between Conscientiousness and Well-Being among Chinese Undergraduate Students: A Cross-Lagged Study
Authors: Hu Yaqi , Wang Zhenhong , Fan Qing
Published: October 2022

Chinese culture attaches great importance to the education and cultivation of youth conscientiousness, however in the context of Chinese culture, little is known about the relationship between conscientiousness and mental and physical health. The present study aimed to investigate whether there is a reciprocal relationship between conscientiousness and well-being (subjective and physical well-being) among Chinese undergraduate students. A series of self-reported questionnaires were administered to 365 undergraduate students in 2 waves, separated by 1 year. Cross-lagged regression analyses were applied to examine the reciprocal relationships. Results indicated that conscientiousness positively predicted subsequent levels of positive affect and life satisfaction, while negatively predicted subsequent levels of negative affect and physical symptoms, controlling for the effects of gender, age, body-mass index, socioeconomic status, and the prior level of conscientiousness. Whereas, positive and negative affect, life satisfaction, and physical symptoms did not significantly predict subsequent levels of conscientiousness. This study suggests that conscientiousness is a robust and prospective predictor of subjective and physical well-being. The reciprocal relationship between conscientiousness and well-being was not confirmed in the current sample of Chinese undergraduate students.
Fatigue during Long-Haul Flights of Different Crew Compositions under Exemption from Layover and Flight Time during COVID-19
Authors: Li Jingqiang , Zhou Yanru , Zhang Xining , Fan Tianchen
Published: October 2022

Pilot fatigue and alertness are critical for civil aviation safety. Intercontinental pilots are more prone to fatigue and sleepiness due to jet lag, prolonged workdays, and disrupted rhythms. The Civil Aviation Administration of China excused enlarged flight crews from mandatory layovers and reimposed flight duration restrictions during COVID-19. This study investigates the sleep quality and attentional performance of pilots on intercontinental flights. The fifteen pilots who performed intercontinental flights in different crew compositions wore a body movement recorder, which has been proven to accurately estimate sleep duration and sleep efficiency. The crew’s attentional performance and self-report were monitored at specified flight phases. In conclusion, the larger crews slept longer and more efficiently on board, particularly pilots in charge of takeoff and landing responsibilities. Crews on four-pilot layover flights were more alert before the takeoff of the inbound flights than exempt flights, but there was no significant difference towards the end of the mission. The new long-haul flight organization did not result in fatigue or decreased attention in the pilots. This study expands on the research by validating a novel intercontinental flight operation model under the COVID-19 scenario and highlighting critical spots for future fatigue management in various crew compositions.
Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD
Authors: Tamaki Yoshitaka , Urushitani Makoto
Published: October 2022

TAR DNA binding protein 43 (TDP-43) is a DNA/RNA binding protein involved in pivotal cellular functions, especially in RNA metabolism. Hyperphosphorylated and ubiquitinated TDP-43-positive neuronal cytoplasmic inclusions are identified in the brain and spinal cord in most cases of amyotrophic lateral sclerosis (ALS) and a substantial proportion of frontotemporal lobar degeneration (FTLD) cases. TDP-43 dysfunctions and cytoplasmic aggregation seem to be the central pathogenicity in ALS and FTLD. Therefore, unraveling both the physiological and pathological mechanisms of TDP-43 may enable the exploration of novel therapeutic strategies. This review highlights the current understanding of TDP-43 biology and pathology, describing the cellular processes involved in the pathogeneses of ALS and FTLD, such as post-translational modifications, RNA metabolism, liquid–liquid phase separation, proteolysis, and the potential prion-like propagation propensity of the TDP-43 inclusions.
BOA/DHB/Na: An Efficient UV-MALDI Matrix for High-Sensitivity and Auto-Tagging Glycomics
Authors: Barada Erina , Hinou Hiroshi
Published: October 2022

Matrix selection is a critical factor for success in glycomics studies using matrix-assisted laser desorption/ionization–mass spectrometry (MALDI–MS). In this study, we evaluated and optimized a new solid ionic matrix—O-benzylhydroxylamine (BOA)/2,5-dihydroxybenzoic acid (DHB)/Na—containing BOA and a small amount of sodium as the counter salt of DHB. The concentration of a mixture of BOA/DHB/Na and glycans on a MALDI target plate led to O-benzyloxy tagging of the reducing ends of the glycans. The BOA/DHB/Na matrix showed excellent aggregation performance and the ability to form a homogeneous solid salt on the MALDI target plate with a water-repellent surface. In addition, the BOA/DHB/Na matrix showed a simple peak pattern with suppressed in-source and post-source decay of the reducing ends of the glycans, as well as improved ionization efficiency of glycans. Utilizing the characteristics of the BOA/DHB/Na matrix, O-glycan analysis of porcine stomach mucin showed excellent detection sensitivity and reproducibility of the peak patterns. This BOA/DHB/Na matrix can accelerate glycomics studies using MALDI–MS and, in combination with other organic salt-type matrices that we have developed, constitutes a valuable tool for glycomics studies.
Transcriptome and Metabolome Analysis of Color Changes during Fruit Development of Pepper (Capsicum baccatum)
Authors: Zhang Yu , Shu Huangying , Mumtaz Muhammad Ali , Hao Yuanyuan , Li Lin , He Yongjie , Jin Weiheng , Li Caichao , Zhou Yan , Lu Xu , Fu Huizhen , Wang Zhiwei
Published: October 2022

Fruit color is one of the most critical characteristics of pepper. In this study, pepper (Capsicum baccatum L.) fruits with four trans-coloring periods were used as experimental materials to explore the color conversion mechanism of pepper fruit. By transcriptome and metabolome analysis, we identified a total of 307 flavonoid metabolites, 68 carotenoid metabolites, 29 DEGs associated with flavonoid biosynthesis, and 30 DEGs related to carotenoid biosynthesis. Through WGCNA (weighted gene co-expression network analysis) analysis, positively correlated modules with flavonoids and carotenoids were identified, and hub genes associated with flavonoid and carotenoid synthesis and transport were anticipated. We identified Pinobanksin, Naringenin Chalcone, and Naringenin as key metabolites in the flavonoid biosynthetic pathway catalyzed by the key genes chalcone synthase (CHS CQW23_29123, CQW23_29380, CQW23_12748), cinnamic acid 4-hydroxylase (C4H CQW23_16085, CQW23_16084), cytochrome P450 (CYP450 CQW23_19845, CQW23_24900). In addition, phytoene synthase (PSY CQW23_09483), phytoene dehydrogenase (PDS CQW23_11317), zeta-carotene desaturase (ZDS CQW23_19986), lycopene beta cyclase (LYC CQW23_09027), zeaxanthin epoxidase (ZEP CQW23_05387), 9-cis-epoxycarotenoid dioxygenase (NCED CQW23_17736), capsanthin/capsorubin synthase (CCS CQW23_30321) are key genes in the carotenoid biosynthetic pathway, catalyzing the synthesis of key metabolites such as Phytoene, Lycopene, β-carotene and ε-carotene. We also found that transcription factor families such as p450 and NBARC could play important roles in the biosynthesis of flavonoids and carotenoids in pepper fruits. These results provide new insights into the interaction mechanisms of genes and metabolites involved in the biosynthesis of flavonoids and carotenoids in pepper fruit leading to color changes in pepper fruit.