bluuebunny/crossref_metadata_2025 huggingface dataset:
REDUÇÃO DE RISCOS NA CADEIA DE SUPRIMENTOS DE UMA INDÚSTRIA DE COMPRESSORES DE AR
Authors: Kanis Junior Ilson , De Oliveira Paulo Rogério Pires Leôncio , Do Vale Rosilda do Rocio
Published: November 2023

O presente estudo tem como objetivo apresentar uma solução para reduzir os riscos da cadeia de suprimentos em uma indústria de compressores de ar, localizada no estado do Paraná. Os dados primários foram coletados por meio de uma pesquisa com os stakeholders do processo. Na sequência foi aplicado um questionário com vinte e oito questões divididas em cinco setores da corporação, sendo: comercial, estoque/logística, suprimentos, produção e administrativo, nas quais os colaboradores responderam de acordo com a empresa em estudo, foi aplicado de forma online e contou com a participação de 50 colaboradores. Posteriormente o mesmo questionário foi aplicado para os colaboradores avaliarem os concorrentes, este foi respondido somente pelos colaboradores que possuíam conhecimento sobre as rotinas dos concorrentes e da própria empresa estudada, a fim de visualizar as diferenças entre ambas e identificar pontos de melhoria na empresa em estudo. A análise dos dados obtidos foi com a utilização da ferramenta Quality Function Deployment - QFD para visualização da cadeia de suprimentos em geral. Das vinte e oito questões, foram priorizadas três questões, sendo as que apresentaram maior percentual e merecem solução de imediato, sendo as questões, Q1 que corresponde a 9,8% de toda a cadeia analisada, Q2 representa 9,7% e Q3 representa 9,4%. Na sequência com a utilização da ferramenta de qualidade PDCA foram apresentadas as soluções e acompanhamento do processo de melhoria para a redução de riscos. Identificou-se que a gestão pode ser alavancada com a visão de todos os stakeholders no uso do QFD e que os riscos podem ser minimizados em 30% se as ações apresentadas forem aplicadas.
Key factors of business sustainability: Strengthening leadership, psychology, and fairness aspects from an Islamic-management perspective
Authors: Putra Aditya Halim Perdana Kusuma , Mansur Daduk Merdika , Ulfah Maria , Nurmiati  , Hajiali Ismail
Published: November 2023

Purpose: The aim of this study is to investigate the relationship between factors in HRM management development and organizational strategy using the philosophical values approach of Islamic studies. The assessment of organizational performance characteristics with strategic management values and psychological techniques in human resource management is part of the study's state-of-the-art and distinctive characteristics.  

Design/Methodology/Approach: The method used in this study is Structural Equation Modeling (SEM) with the selection of analysis using non-parametric Smart-PLS. We analyzed 256 samples of lecturers at several private universities within the LLDIKTI-IX, Sulawesi, Indonesia.

Findings: 14 hypotheses are reviewed in this study. According to our findings, 13 hypotheses have a positive and significant effect on the dependent variable. The antecedents of Islamic management values, leadership style, religiosity   and fairness can increase complex effects on organizational motivation, HRM engagement, performance   and organizational sustainability.

Conclusion: Our findings provide theoretical and managerial reinforcement of various long-term strategic considerations to support the effect of organizational sustainability by reviewing the HRM aspect as an intangible asset.

Research Implications: This study contributes to broadening the theoretical understanding of strategic management studies developed with a psychological approach as well as Islamic value management.

Practical Implications: Organisations must pay attention to various crucial variables to boost job satisfaction, motivation and employee engagement such as HR development components and work evaluations carried out and developed on a regular basis.
Transforming economics towards tackling teachers' challenges in teaching economics: A case of selected schools in buffalo city metropolitan South Africa
Authors: Adu Emmanuel Olusola
Published: November 2023

Introduction/Purpose:  Economics is a dynamic subject whose students use the contents to address real-life problems. Therefore, this paper examines the transformation of economics to tackle teachers’ challenges in the teaching of economics.  

Design/Methodology/Approach: This paper used a qualitative research technique to collect information from teachers based on a phenomenological research design.  A purposive sampling technique was used to select 12 teachers of economics in 6 selected schools in Buffalo City. A semi-structured interview was used to elicit information from the respondents and the data were analysed using a thematic approach.

Findings: The study identifies certain notable issues including imprecise economics curriculum materials and learners' inability to demonstrate interest due to various statistics and data components of the subject.  Teachers' participation in professional development activities such as seminars, in-service training and workshops for knowledge updates is one of the solutions offered to overcome these difficulties.

Limitation: This paper uses only 12 economics teachers from Buffalo City metropolitan municipality. Larger samples can be used in another municipality. A quantitative approach can be used to accommodate representative samples.

Practical Implications: Teachers are expected to be at the forefront of disseminating the contents of the subject appropriately because a teacher can only give what he or she has. Teachers should be proactive and current with the recent developments in the nation and be technologically compliant.

Contribution to the Literature: This paper contributes to the literature by highlighting practical solutions to the challenges teachers face during the teaching of economics.
The synthesis of acetone from isobutane with the intermediate of di-tert-butyl peroxide
Authors: Li Ning , Li Chunyi
Published: November 2023

Acetone, a widely used chemical raw material, is synthesized by the cumene peroxide method. At present, the cumene peroxide method has the disadvantage of high raw material cost, low flexibility, and complex process. Isobutane as an important C4 resource is mainly used as liquefied gas, which is a waste of fossil resources. Based on that, a novel acetone synthesis method from isobutane with the intermediate of di-tert-butyl peroxide (DTBP) is proposed. The reaction performance of TiO2-S and the optimal reaction condition for isobutane selective oxidation to DTBP is evaluated, and the selectivity to DTBP is 30 wt%. Then, the ZSM-5 is proved as the optimal catalyst for DTBP decomposition and the acetone selectivity is 38 wt% under the optimal reaction condition. In general, isobutane selective oxidation to DTBP which is further catalytic decomposition to acetone is feasible.
Impact of Tax Rates and Sales Growth On Tax Avoidance
Authors: Suaidah Imarotus , Rahayu Puji
Published: November 2023

This research aims to examine the effect of tax rates and sales growth on tax avoidance. This research is focused on telecommunications companies listed on the Indonesia Stock Exchange (IDX) for the 2017-2022 period. The sampling technique uses the purposive sampling method which amounts to 42 samples. As for the data analysis technique used is multiple regression analysis by testing classical assumptions first. The results of the data analysis that have been carried out show that the tax rate does not affect tax avoidance in telecommunications companies, while sales growth has an influence on tax avoidance of 0.389 which is included in the low category, then the tax rate and sales growth have an influence together on tax avoidance by 13.5%.
A INCIDÊNCIA DAS NORMAS PROTETIVAS DA CRIANÇA E DO ADOLESCENTE SOBRE O ART. 75, §1º DA LEI Nº 6.815/1980 COMO FATOR IMPEDITIVO DA EXPULSÃO DO ESTRANGEIRO
Authors: Corloski Jéssica Pereira
Published: November 2023

O presente trabalho objetivou analisar a recente alteração jurisprudencial promovida pelo julgamento do Recurso Extraordinário nº 608.898/DF, em sede de repercussão geral, que concluiu pela não recepção do artigo 75, § 1º da revogada Lei nº 6.815/1980, pela Constituição Federal de 1988, considerando o arcabouço normativo de proteção especial da criança e do adolescente.
PREVALÊNCIA DE ACIDENTE VASCULAR CEREBRAL EM IDOSOS E SUA REABILITAÇÃO FISIOTERAPÊUTICA
Authors: Barbosa Maria Vitória Lopes , Bento Rozânia de Jesus , Do Nascimento Carlos Geraldo Ribeiro
Published: November 2023

O Acidente Vascular Cerebral (AVC) consiste em lesões dos tecidos cerebrais por perda de irrigação sanguínea, causada por ruptura direta dos vasos sanguíneos ou sua obstrução por um trombo (Gomes et al., 2013). A lesão cerebral dos AVCs tem efeito direto nas atividades da vida diária (AVDs), paralisia e deficiência de linguagem, deficiência visual, deficiência de marcha e perda de equilíbrio e controle motor (McGlinchey et al., 2018). Trata-se de um estudo de revisão bibliográfica, cujos objetivos foram identificar a prevalência do AVC (acidente vascular cerebral) em idosos e a reabilitação para essa patologia. A pesquisa foi feita com 25 artigos, dos quais 13 estão no trabalho de fato, onde apontam três atigos que falam sobre o ganho de equilíbrio, tendo como técnicas de tratamento, treinamentos em diferentes superfícies de apoio, treino de marcha para trás e treinamento de caminhada, treinamento de caminhada na piscina e em esteira. Identificar essa população com AVC em idosos e sua reabilitação servirá de base de pesquisa para outros trabalhos futuros de revisão bibliográfica.
PESQUISA NA EDUCAÇÃO GEOGRÁFICA E PRÁTICA DOCENTE
Authors: Lopes Jaime Sergio Frajuca
Published: November 2023

Nesse artigo, será abordado a prática docente na disciplina de Geografia, enfocando métodos, técnicas e procedimentos de ensino. Destaca a importância de os professores de Geografia serem bons articuladores, dada a natureza multidisciplinar da matéria, e ressalta a necessidade de desvincular a prática da teoria. Discute a necessidade de repensar e inovar os métodos de ensino tradicionais, especialmente em um mundo cada vez mais tecnológico. O Artigo, como postulado teórico, enfatiza que o desafio da educação no século XXI é transformar teoria em prática, associando ao uso de tecnologias, sem abandonar o modo tradicional, comprometendo-se com valores morais, éticos e culturais. Aborda a diferença entre didática e método, destacando que a didática se relaciona com as ferramentas de ensino, enquanto o método diz respeito à forma de construir o conhecimento. O processo de avaliação é abordado como uma ferramenta de diagnóstico situacional dos alunos, enfatizando a importância de avaliar o aprendizado e não apenas punir os alunos com notas. O artigo também ressalta a necessidade de utilizar técnicas variadas de ensino, que possibilitem uma compreensão mais clara dos conteúdos, bem como o uso de tecnologias disponíveis na educação.
Genetic polymorphism of retinol binding protein 4 locus and its association with litter traits in pigs
Authors: B RAGHAVENDRAN V , VENKATACHALAPATHY R THIRUPATHY , P USHA A , PRAMOD S
Published: November 2023

Retinol binding protein 4 (RBP4) gene was investigated to find its association with litter traits using PCR-RFLP method in RBP4 locus. The Msp1 polymorphism was observed in the third intron region of RBP4 gene. Genotypes, AA, AB and BB were observed with frequency of 0.48, 0.28 and 0.24 respectively. Homozygotes were predominant in LWY and crossbred whereas, heterozygote was predominant in Duroc. The frequencies of RBP4 allele A were 0.61 in the LWY, 0.48 in Duroc and 0.71 in the LWY × Ankamali pigs. RBP4/Msp1 genotype had no significant association with litter traits. Sows carrying RBP4 - AA genotype had higher litter size and weight at birth, but not significant. Five single nucleotide polymorphisms were identified in RBP4 565bp fragment nucleotide sequences, 4 were found in intronic regions and 1 silent substitution in exon region.
Impact of pesticide residues on fertility of dairy animals: A review
Authors: GHUMAN S P S , RATNAKARAN U , BEDI J S , GILL J P S
Published: November 2023

Dairy animals are exposed to a number of pesticides during lifetime. Although, the level of exposure of individual pesticide is usually too low to induce any acute impact on reproductive system, but the combinations of pesticide residues can act additively or synergistically to cause chronic disturbances in hypothalamo-pituitary-gonadal system at all ages and especially in the developing fetus/neonates. The concern is increasing regarding the ability of some pesticide residues, known as endocrine-disrupting chemicals, to disrupt the synthesis, function and metabolism of reproductive hormones. At present, many potential sites of action of pesticide residues have been identified but the knowledge regarding long-term synergistic impact of pesticide residues on reproductive systems is poor especially in dairy animals. The pesticide residues can impair semen quality, as well as female fertility. The present paper identifies the risks to fertility of dairy animals posed by wide spread contamination of our environment with pesticide residues.
Assessment of avoidable yield losses due to insect pests and diseases in wheat (Triticum aestivum)
Authors: JADHAV MAHESH M , S CHANDER , SAHARAN M S , SUROSHE SACHIN S , RAJNA S
Published: November 2023

Biotic stress, including insect pests and diseases, poses a significant constraint to the cultivation of food grain crops including wheat (Triticum aestivum L.) which is affected by several pests. Therefore, the present study was carried out during winter (rabi) seasons of 2020–21 and 2021–22 at the research farm of ICAR-Indian Agricultural Research Institute, New Delhi to assess the yield loss due to multiple pests in a holistic manner with wheat variety HD 3086 (Pusa Gautami). Estimated avoidable yield loss due to higher aphid infestation and minimum disease incidences of Karnal bunt and black point disease during both the seasons (2020–21 and 2021–22) was 7.79% and 6.10%, respectively. Meanwhile, in treatment with a lower aphid infestation and minimum disease incidence of Karnal bunt and black point diseases, yield losses were 4.80% and 6.90% in 2020–21 and 2021–22, respectively. Incidences of the diseases were found to be minimal in both the seasons, thus the estimated avoidable losses attributed to aphids to a large extent.
Comprehensive comparative toxicity study on tomato (Solanum lycopersicum) and brinjal (Solanum melongena) using green labelled insecticides against Bemisia tabaci
Authors: T ANIL KUMAR S , M NIKHIL R , S RAJNA , MAHAPATRO G K
Published: November 2023

Bemisia tabaci a serious sucking pest of tomato (Solanum lycopersicum L.) and brinjal (Solanum melongena L.), is mostly managed using high-dose conventional insecticides, which are harmful for end-users and the environment. Target-insect is also known to exhibit host-dependent variation in insecticidal toxicities; therefore an experiment was conducted during 2020–22 at ICAR-Indian Agricultural Research Institute, New Delhi, to study the host-specific toxicity relationships on tomato and brinjal using market-available safer insecticides with green labels in the Indian context. Bioefficacy evaluated on eggs, nymphs, and adults using leaf-dip bioassay (IRAC) recorded higher LC50 for candidate insecticides (clothianidin, spinetoram and cyantraniliprole), but lower toxicities for azadirachtin and novaluron for test-insects reared on brinjal. The possible role of test-leaf on LC50 was evaluated in a reciprocal way, i.e. test-populations grown in tomato were subjected to brinjal leaf bioassay and vice versa. This resulted to no significant change in LC50 and implies no effect of the test leaf. Feeding (honeydew excretion) and oviposition studies showed higher honeydew excretion (76.4 mm2) and egg-laying (43.6 eggs) per 20 adults on brinjal. Detoxification enzymatic activities in control showed the test enzymes, viz. carboxylesterase, glutathion S-transferase and cytochrome P450 monooxygenase, were at higher concentrations in the brinjal population, i.e. 1.75, 1.43 µ mol/min/mg, and 3.10 n mol/min/mg of protein. Results showed that brinjal is the preferred host for B. tabaci, on which it develops healthier and resulting in a higher insecticide dose to arrive at the desired lethal effect.
Effect of bagging materials and time on fruit quality of litchi (Litchi chinensis) cv. Shahi in Nagaland
Authors: KUMAR K AJAY , MAITI C S , ALILA PAULINE , SARKAR A , PATIL PRAKASH
Published: November 2023

The present experiment was conducted during 2020–22 at research farm of School of Agriculture Sciences, Nagaland University, Medziphema campus, Nagaland on effect of bagging in quality of litchi fruits cv. Shahi was Experiment conducted by using3 different bagging materials, i.e. Non- woven Polypropylene White (PPW), Polypropylene Pink (PPP), Brown paper Bag (BPB) and control (no bagging) were used to bagged the fruit bunches at three different days after fruit set, viz. 15 DAFS, 25 DAFS and 30 DAFS. Results indicated that PPP bags gave the best result with higher total sugar (15.21%), TSS (21.30 ºB), TSS: acid ratio (50.34) and low incidence of sunburn (3.59%), fruit cracking (1.71%) in comparison to control, whereby, higher values of anthocyanin content (26.11 mg/100 g) and fruit weight (23.12 g) were recorded in BPB. PPP and BPB bagging materials were found to be the best of the treatments to create mean microclimate inside bag to improve fruit colour and other quality parameters. In the case of time of bagging, 15 DAFS was found to give higher performance as compared to 25 DAFS and 30 DAFS with maximum individual TSS content (21.30 ºB), TSS-acid ratio (50.34) and low Sunburn (3.59%) and cracking percentage (1.71%). As such, bagging with PPP at 15 DAFS was found to give the best treatment.
Biological control of fruit rot of postharvest orange (Citrus aurantium) by aqueous plant extracts
Authors: OKON OKON GODWIN , RHOUMA ABDELHAK , ISMAILA UWAIDEMYAKUBU , MATROOD ABDULNABI ABBDUL AMEER , HAJJI-HEDFI LOBNA
Published: November 2023

Post-harvest rot symptoms caused by complex airborne fungi are nowadays the most serious threatening disease affecting orange fruits in Nigeria and presumably in many African countries. Experimental trials were conducted at the Department of Biological Sciences (Akwa Ibom State, Nigeria) from January to December 2022 to ascertain the pathogens associated with postharvest fruit rot of oranges (Citrus aurantium L.). Results of the pathogenic test revealed that Fusarium sp. and Penicillium sp. are pathogenic and produced the highest lesion diameter (38.67 and 40.33 mm, respectively) and disease severity index (88.67 and 94.33%, respectively). The frequency occurrence of Fusarium sp. (69.14%) and Penicillium sp. (50.62%) was the highest. Two aqueous extracts of Azadirachta indica Juss. leaves and Zingiber officinale Roscoe rhizomes (at 80% concentration) were evaluated for their antifungal activities against the pathogenic isolates under in vitro and in vivo conditions. The results revealed that A. indica and Z. officinale aqueous extracts exhibited the highest mycelial growth inhibition (>90%) of Fusarium sp. and Penicillium sp. Similarly, under in vivo assay minimum lesion diameter (≤ 6.37 mm) and disease severity index (≤11.13%) were recorded in these aqueous extracts. In conclusion, the application of A. indica and Z. officinale can provide an alternative to fungicides against Penicillium sp. + Fusarium sp.
Crop yield, water use efficiency and economic assessment of purple broccoli (Brassica oleracea) across varied water and nitrogen management practices
Authors: KIRUTHIGA B , SINGH MAN , KHANNA MANOJ , SINGH SHRAWAN , PARIHAR C M , BANDYOPADHYAY K K , KUMAR S NARESH , RAJPUT JITENDRA , N KISHOR
Published: November 2023

Inefficient management of irrigation and fertilizers emerges as the primary hurdle constraining the crop performance, profitability of broccoli (Brassica oleracea L. var. italica) production, resource wastage and environmental harm. To address this issue, a field experiment was conducted during winter (rabi) seasons of 2020–21 and 2021–22 at the research farm of ICAR-Indian Agricultural Research Institute, New Delhi. The research focused on investigating the effect of irrigation techniques and nitrogen management on broccoli yield, water use efficiency (WUE) and economic feasibility. The two main irrigation methods of drip irrigation and furrow irrigation as main factor, 2 irrigation regimes of full irrigation (100% ETC) and limited irrigation (75% ETC) as sub-factor, 3 nitrogen doses (N) of 125, 100 and 75% recommended dose of N as sub-sub factor were given and replicated thrice. The study aimed to analyse the yield, water use efficiency and assessment of economics under diverse irrigation water and N-management approaches. Under drip irrigation the mean yield and water-use efficiency shown substantial increase by 12 and 52% in comparison with furrow irrigated purple broccoli grown under the same condition. The highest benefit to cost (B:C) ratio of 3.81 and 4.79 was obtained in the treatment DRI1N1 during 2020–21 and 2021–22, respectively. Undoubtedly, the significance of adequate irrigation regime (100% ETC) and optimal N dose (125% RDN) became apparent, as they played significant roles in enhancing crop performance and ensuring the attainment of maximum broccoli yield, WUE and economics in Trans-Gangetic Plains region.
Effect of gamma irradiation on growth and corm yield of gladiolus (Gladiolus grandiflorus) varieties
Authors: CHOUDHARY RISHIKA , KUMAR ANUJ , KANWAR JYOTI , KACHOULI B K , YADAV BALI RAM
Published: November 2023

The data analysis has revealed distinct performance trends among different aspects of gladiolus cultivation. Specifically, Arka Kesar, a gladiolus variety, demonstrated superior growth characteristics, excelling in terms of plant height, the length and width of the longest leaf at both 30 and 60 days after planting (DAP). On the other hand, Arka Tilak outperformed in the number of corms and cormels per plant. Furthermore, the application of gamma irradiation at a level of 1.25 kr was found to be advantageous for several growth parameters. It positively influenced plant height, the number of leaves per hill, the length and width of the longest leaf at both 30 and 60 DAP, as well as the number of corms and cormels per plant. In conclusion, the study suggests that the Arka Kesar variety, when subjected to 1.25 kr gamma irradiation, displayed significant superiority across multiple growth parameters in gladiolus cultivation in the Malwa region of Madhya Pradesh, India. However, for corm yield specifically, Arka Tilak irradiated with 1.25 kr demonstrated better performance. These findings provide valuable insights for optimizing gladiolus cultivation practices in the region.
O papel do eixo intestino-cérebro-microbiota em doenças neurodegenerativas
Authors: Galvão Stéfani Lara , Gomes Gabriel Felipe , Santos Júlio César Claudino dos
Published: November 2023

O eixo intestino-cérebro-microbiota é o comunicador entre dois sistemas do nosso corpo, o sistema gastrointestinal e o sistema nervoso central (SNC) (SANTOS et al., 2023). Por meio dele, ocorrem interações biológicas e fisiológicas que envolvem e se correlacionam com muitas condições, como doenças neurodegenerativas, ansiedade, esquizofrenia e obesidade (CRYAN et al., 2019; QUIGLEY, 2017). As doenças neurodegenerativas compreendem um conjunto de doenças, de diferentes etiologias, caracterizadas pelo acúmulo de substâncias neurotóxicas que contribuem para o dano neuronal devido à degeneração cerebral.
Icodec: uma revolução no tratamento do diabetes mellitus
Authors: Guimarães Henrique Malta , Alvarenga João Victor Sales , Viviani Júlia Santos Mazine , Marques Lívia , Gyotoku Larissa Cocicov
Published: November 2023

A insulina é o hormônio peptídico produzido pelas células beta das ilhotas de Langerhans pancreáticas responsável pela captação de glicose pelas células de modo que sua falta ou dificuldade de ação cursa com hiperglicemia que, por sua vez, caracteriza o Diabetes Mellitus (DM). Assim, para o tratamento do DM desenvolveram-se insulinas extraídas do pâncreas bovino e suíno similares ao hormônio humano, com duas cadeias interligadas de aminoácidos, não podendo ser administradas por via oral devido à degradação enzimática gastrointestinal, com aplicação subcutânea (KRALL, 1983).
Technology-enhanced active learning: método ativo para o ensino médico, uma revisão bibliográfica
Authors: Ximenes Maria Alice da Costa , Allo Maria Fernanda Rodrigues Lopes , Mancim Mariana de Sordi , Gyotoku Larissa Cocicov
Published: November 2023

As novas tecnologias em evidência no mundo atual são promissoras ferramentas para o aprimoramento do ensino médico, auxiliando como cenário de simulações e estudo para os alunos (MCCOY, L. et al., 2015). As novas metodologias começaram com o uso de bonecos e manequins computadorizados, e progrediram para que, atualmente, surgisse a a technology-enhanced active learning (TEAL) (SHARMA, N.; DOHERTY, I.; DONG, C., 2017).
Avanços da cirurgia robótica no tratamento de pacientes com doenças cardiovasculares: uma revisão integrativa
Authors: Moreira Leonardo Caruba , Cunha Isabela Cristina Oliveira da , Moraes Bruno Teixeira Marcos , Jesus Letícia Wendel Madeira de , Oliveira Julia Alves de , Lebet Roberto
Published: November 2023

As Doenças Cardiovasculares (DCVs) são consideradas as principais causas de óbitos no mundo e são caracterizadas por afetarem o músculo cardíaco e os vasos sanguíneos. Sabe-se que há vários fatores predisponentes para o surgimento das DCVs, sejam elas modificáveis ou não, sendo os principais: dislipidemia, hipertensão arterial sistêmica, diabetes mellitus, tabagismo, obesidade, consumo abusivo de álcool e de gorduras (FIGUEIREDO et al., 2020; FREIRE et al., 2017).
Perspectivas da imunoterapia como tratamento promissor para as síndromes mielodisplásicas
Authors: Ticotosti Giovana Girardi , Balieiro Marcela Bocalete , Beine Thálita Cristina de Sousa , Soares Carolina Bojikian , Silva Ana Carolina Costa da
Published: November 2023

As Síndromes Mielodisplásicas são um grupo de distúrbios hematológicos que se caracterizam por uma produção inadequada de células precursoras sanguíneas na medula óssea, podendo, dessa maneira, repercutir em alterações em todas as linhagens celulares (MONTALBAN-BRAVO; GARCIA-MANERO, 2017). Apesar de representarem um grupo heterogêneo de patologias, possuem em comum o defeito clonal em células progenitoras e a maior incidência em idosos.
Aprendizados e experiências em libras
Authors: Pires Julia da Palma , Meneghetti Carolina de Fátima , Tabanez Lara , Brussolo Victória Maria de Oliveira , Justino Yasmin , Varella Soraya Duarte , Quagliato Fábio Franchi
Published: November 2023

Apesar da oficialização da Língua Brasileira de Sinais (Libras) como língua das pessoas surdas no Brasil em 2002 (BRASIL, 2002), ela ainda é pouco utilizada em todos os setores, inclusive o da saúde. O desconhecimento pelos profissionais, além da falta de uma formação inclusiva, decorrente da ausência do ensino da Libras na graduação (MAZZU-NASCIMENTO, 2020), dificulta ainda mais o acesso das pessoas surdas aos serviços de saúde. Mesmo quando acessados, há um descontentamento e insatisfação com a atenção prestada (CASTRO, 2012).
Improving Sales Volume To Maintain Business Sustainability Through Digital Marketing And Financial Literacy For Msmes In Cilodong, Depok
Authors: Dewi Nur Fitri
Published: November 2023

Along with the dynamics of MSMEs in Indonesia, their development faces several problems related to whether the sustainability of MSMEs in Indonesia can be tested in the long term. The aim of this research is to determine the influence of digital marketing and financial literacy on sales volume and its impact on business sustainability in MSMEs in Cilodong, Depok, West Java. The population of this study is MSMEs Cilodong District, Depok City, West Java. The data collection method was a questionnaire distributed to 60 samples of MSMEs in Cilodong, Depok. The collected data was processed using SPSS 27.00 with t test and Path Analysis. The research results show that digital marketing and financial literacy have a positive effect on sales volume. Digital marketing and financial literacy also have a positive influence on business sustainability, both directly and indirectly, mediated by sales volume. Apart from that, sales volume has a direct effect on business sustainability. The results of this research can be useful for MSMEs as input and consideration in determining strategies, especially regarding Sales Volume and Business Sustainability of MSMEs in Cilodong, Depok.
Srategi Guru Akidah Akhlak dalam Membentuk Kecerdasan Spiritual Pada Siswa di Madrasah Aliyah Swasta
Authors: Ilham Muhammad
Published: November 2023

This article discusses the strategy of aqidah moral teachers in forming spiritual intelligence in students at the Tanjung Private Madrasah Aliyah, Bathin VIII District. Based on qualitative research, data collection was carried out by observation, interviews and documentation. Data analysis was performed using domain analysis, taxonomic analysis and componential analysis. The research findings state that the teacher's strategy of aqidah morals in shaping students' spiritual intelligence is carried out by accustoming students to doing something good and right, and strengthening religious education and adding religious material to each class. Inhibiting factors faced by teachers include; student personality, the influence of the friendship environment, the influence of association outside of school, the lack of cooperation with student guardians, the lack of educational support facilities. Meanwhile, the teacher's efforts to overcome these obstacles include; increasing cooperation between schools and parents, establishing cooperation with students, and creating good conditions during the learning process.
Artikel ini membahas tentang strategi guru akidah akhlak dalam membentuk kecerdasan spiritual pada siswa di Madrasah Aliyah Swasta Tanjung Kecamatan Bathin VIII. Berbasis pada penelitian kualitatif, pengumpulan data dilakukan secara observasi, wawancara dan dokumentasi. Analisis data dilakukan dengan menggunakan analisis domain, analisi taksonomi dan analisis komponensial. Temuan penelitian menyebutkan bahwa strategi guru akidah akhlak dalam membentuk kecerdasan spiritual siswa dilakukan dengan cara membiasakan peserta didik melakukan sesuatu yang baik dan benar, dan memperkuat pendidikan agama dan menambah materi agama disetiap kelas. Faktor penghambat yang dihadapi guru antara lain; pribadi peserta didik, pengaruh lingkungan pertemanan, pengaruh pergaulan diluar sekolah, kurangnya kerjasama dengan wali murid, kurangnya sarana penunjang pendidikan. Sedangkan upaya guru dalam mengatasi kendala tersebut antara lain; meningkatkan kerjasama antara sekolah dan orang tua, menjalin kerjasama dengan peserta didik, dan menciptakan kondisi yang baik di saat proses belajar berlangsung.
Phraseologies In German Related To Animal Wildlife
Authors: Abdiloyev Sh.O.
Published: November 2023

German and Uzbek. The focus is on badger, lynx, frog, bear, rabbit, donkey, and pig, bringing a special dimension to the way these two languages represent the relationship between humans and nature. Comparative analysis methods are used to investigate differences and similarities in linguistic structures and cultural contexts, providing an in-depth understanding of how German and Uzbek peoples articulate their values, beliefs, and experiences through this unique phraseology. This research approach includes representative sample selection, linguistic and semantic analysis, and contextual comparison. By understanding the way zoomorphemism phraseology reflects worldview and culture, this research seeks to unravel the linguistic richness and cultural values embedded in language. The results can provide significant insights into the uniqueness and continuity of these linguistic and cultural aspects, enriching our understanding of linguistic heritage in the context of multicultural societies.
Drosophila melanogaster as a Model Organism to Facilitate Rare Disease Diagnosis and Therapeutic Research
Authors: Dsouza Kalyla Kristina , Pappuswamy Manikantan , Chaudhary Aditi
Published: November 2023

Cancer is one of the leading causes of death worldwide accounting for around 10 million deaths in 2020. Cancer is caused by abnormal growth of cells in any part of the body. Genetic causes of cancer can be due to mutations in the genes. Rare mutations in genes show rare types of tumors like Neurofibromatosis and Tuberous sclerosis. The study of model organisms has been pivotal in understanding the causes of various diseases. The studies involve a variety of different methods and out of them the WES (Whole Exome Sequencing) model of research is the most common. Herein lies the future of integrating human genomics with studies in model organisms. It is essential to maintain and expand the current Drosophila melanogaster databases this houses the genomic, molecular, and cell biological knowledge on the organism. This can be done by collaboration with the NIH. The understanding of the characteristics of cancer cells plays an important role in terms of how to go about with research tumor and normal host cell motility plays a multifaceted role in the metastasis of cancer by allowing the tumor to spread to distant organs, migrate to blood and lymphatic arteries, breach the basement membrane, and escape from the original tumor. The ability to migrate towards favourable environments is a fundamental and evolutionarily conserved cellular behaviour from unicellular organisms to humans. Both normal and cancer cells migrate using diverse modes including amoeboid, mesenchymal, epithelial, collective and individual. Simple model organisms also exhibit these diverse modes of motility and offer experimental advantages such as low cost, amenability to large-scale genetic and pharmacological screening and live imaging of cells interacting within their native environments. This article goes into detail about how drosophila can be used as a model organism to study various diseases such as Duchenne Muscular Dystrophy, Parkinsons disease, Prions diseases, Polyglutamine disorders, Huntington's disease, Machado-Josephs disease, Kennedy disease, Amyotrophic lateral sclerosis, Leigh Disease, Nieman-Pick Disease and a few rare tumours
Epidemiological Assessment of Bovine Foot and Mouth Disease in different Sized Herds and among Species and Breed in Tamil Nadu, India
Authors: Krishnan L. Murali , Christy R. John , Anbiah S. Vigil , Imayavaramban V.
Published: November 2023

The dairy industry encounters substantial challenges due to livestock diseases that pose a threat to farmers' livelihood, food security and economy. Among the bovine diseases, Foot and Mouth disease (FMD) is most contagious and economically important. Epidemiological survey was conducted among dairy farmers and the results indicated that the prevalence of FMD was more in large herds (6.58%) followed by medium (6.32%) and small herds (5.55%).The mortality rates were more in large herds (1.15%) than medium (0.91%), and small herds (0.85%). Case Fatality Rate (CFR) was higher in large herds (16.92%) compared to medium (14.03%) and small herds (12.50%).However, the prevalence, mortality and CFR did not vary significantly (P>.05) between different herd sizes. Among breeds, the prevalence of FMD was high in indigenous cattle (8.63%) followed by crossbreds (6.32%) and buffaloes (3.09%) and the difference was significant (χ2=9.04; P=.01). The mortality rate was higher in crossbreds (1.42%) compared to indigenous breeds (0.45%) but non-significant (P>.05). Notably, the CFR was significantly higher (Fischer’s exact=5.531; P=.02) in crossbreds (22.61%) than in indigenous breeds (5.26%). To avoid sporadic incidences, it is essential to enhance vaccination coverage, biosecurity measures, farmers’ awareness, treatment facilities, movement restrictions and quarantine practices.
DEVELOPMENT OF TRADITIONAL GAME BOOKS AND MOTOR COORDINATION
Authors: Ali Masnur
Published: November 2023

This research aims to produce a Traditional Game Book for Developing Coordination. With the development of this book, it will add references and become an alternative for learning and games that can be done in the home environment, school and on campus. This book aims to enable students to understand more fully about traditional games, be able to play traditional games with various biomotor skills and preserve traditional sports by playing games that can improve motor skills. This research is development research or Research & Development. The research data instruments consist of assessment instruments by validators (material, language and media), and media-based questionnaires based on research sample responses. The samples in this study were taken using a purposive sampling technique, taking into account the following conditions; 1) All students have taken Traditional Sports courses; 2) students are taught by the same lecturer. The overall results of this research data analysis show a figure of 75.37%. Therefore, it can be concluded that the completeness of the traditional game manual developed is at a level suitable for use as a learning medium.
Daridorexant: A drug to treat insomnia
Authors: Tyagi Harsh , Sharma Amit , Khera Nikita , Sharma Bintoo , Bajaj Megha , Kaur Mandeep
Published: November 2023

In this review, we have explained the drug “Daridorexant” which is been used for the treatment of insomnia. Clinical research has shown, however, that individuals with insomnia have inconsistent reporting of subjective (i.e., self-reported diaries) and objective (i.e., polysomnography) estimations of their sleep characteristics. Idorsia Pharmaceuticals Ltd. is developing daridorexant (Quviviq™), an orally given dual orexin Type 1 and Type 2 (OX1 and OX2) receptor antagonist (DORA), for the treatment of insomnia. Daridorexant was chosen from a pool of medication candidates because it had estimated effect duration of 8 h at a dosage of 25 mg and a half-life designed to minimize residual effects that might impede daytime functioning. Symptoms have been self-reported by approximately 30% of the general population and can cause a wide range of daily impacts such as fatigue, decreased energy, mood changes, and cognitive impairments. We have explained the pharmacokinetics and pharmacodynamics profile of Daridorexant. It preferentially targets orexin neurons and inhibits downstream neuronal pathways that promote wakefulness; however, it does not affect neuronal pathways that induce adverse effects found with positive allosteric gamma-aminobutyric acid-A receptor modulators. In the context of arrestin-mediated pathways, the possibility of biased signaling is being investigated. The drugs used in the orexinergic system are also included in this review.
Europa
Authors: Schrötter Hans Jörg
Published: November 2023

Was ist der Unterschied zwischen Europäischem Rat und Europarat? Wo liegen die Ursachen für die zahlreichen Krisen, die Europa gemeistert – oder noch vor sich – hat? In seiner 4., überarbeiteten und aktualisierten Auflage erklärt das Buch, wie unser neues Europa funktioniert, welche ungeahnten Freiheiten und Chancen es uns bietet – und warum es mitunter nicht funktioniert. Anschaulich analysiert der Autor das gesamte Spektrum aktueller Themen – von den Turbulenzen um den Euro, die Flüchtlingspolitik, den Brexit und Fridays for Future bis hin zum „Green Deal“ und dem Angriffskrieg Russlands auf die Ukraine. Europa ist kein Elite-Projekt. Dieses bewährte, leicht lesbare Taschenlexikon lädt Einsteiger wie Europa-Kenner gleichermaßen ein, mitzumachen, zu kritisieren und zu diskutieren. Europa ist zugegeben unperfekt, aber es ist das Erstaunlichste, was wir auf unserem Kontinent in den letzten Jahrhunderten auf die Beine gestellt haben.
Der Einspruch als Legitimationsbasis des Strafbefehlsverfahrens?
Authors: Bonheur Thorsten
Published: November 2023

Why do the recipients of penalty orders refrain from appealing? What decision-making process do they go through in the process? For the first time, a paper provides answers to these and other questions surrounding the motives and thought processes behind the failure of sentencing order recipients to appeal on an empirical basis. The new insights gained by the author through interviews with sentencing order recipients are not only likely to help shape research in this practically significant area. At the same time, they provide an occasion for reviving the legal policy debate surrounding the criminal order procedure.
M2M-Vertragsschlüsse im deutschen und italienischen Recht
Authors: Wasl Fabian
Published: November 2023

Regarding the German and the Italian Civil Codes, which are characterized by the doctrine of person, the adoption of voluntative contractual elements by software agents and the resulting possibility of M2M contract conclusions raise fundamental questions about the attribution of such declarations. Against this background, the unilateral use of technical and digital tools for contractual declarations is analyzed from a functional comparative law perspective. Based on the knowledge gained, the respective existing dogmatic opinions for the conclusion of M2M contracts are examined on the basis of examples and potential disruptions of the technology.
Datenkooperation durch Datenpooling
Authors: Schäfer Lara
Published: November 2023

How to create data cooperations, including data pools, as accelerators of data-based competition without, in turn, creating new dangers for competition? This book addresses that hurdle interdisciplinarily. A factual and economic classification of data pools builds the ground for their examination in the light of competition law and recent regulatory products of the European data strategy. Against this backdrop, selected reform options are discussed focusing on a more generous practice of exemption under Art. 101(3) TFEU and on more administrative guidance for data pools. In addition, a readjustment of the Data Governance Act and the Data Act is considered while basically preferring a cautious regulatory approach with regards to data pools.
Symbolische (Ver)Formungen
Authors: Kimminich Eva
Published: November 2023

Diese erste Einführung in die Kultursemiotik stellt Kultur als symbolbasierte Programmatik vor, mit der eine Gesellschaft ihre Lebenswelt (um)gestaltet. Dabei wird deutlich, wie die jeweiligen Zielsetzungen der Weltgestaltung aus dem zweckbestimmten Gebrauch ihrer zentralen Denkfiguren hervorgehen. Anschauliche Beispielanalysen und (Um)deutungsprozesse von Konzepten wie Raum, Zeit, Arbeit, Familie, Geschlecht und Wachstum werfen Schlaglichter auf die ambivalente Entwicklungsgeschichte der westlich kapitalistischen Kultur. So lässt sich soziokultureller Wandel im Zusammenhang mit technologischen Entwicklungen und ökonomischem Gewinnstreben als eine fortwährende symbolische (Ver)Formung der Lebenswelt lesen. Erklärvideos sorgen für einen erleichterten Zugang zu Theorien und Analysen.
Reviews on Statin-associated Side Effects
Authors: Wu Qiutong , Fang Lu , Zhu Yujie , Zheng Lemin
Published: November 2023

Statins are a class of drugs widely used worldwide to manage hypercholesterolemia and prevent secondary heart attacks. They have an important role in reducing morbidity and mortality in patients with cardiovascular disease. Due to their wide range of biological effects, some potential therapeutic effects of statins have also attracted increasing attention, such as the treatment of multiple sclerosis, systemic lupus erythematosus, Alzheimer’s disease, and chronic liver disease. However, a major problem with these kinds of applications is that long-term use of statins also has certain adverse reactions. These adverse effects include liver injury, myopathy, new-onset type 2 diabetes, renal dysfunction, interstitial lung disease, and other reactions. This article mainly reviews the adverse reactions of statins in clinics, aiming to provide a reference for the clinical application of these drugs.
Beyond Cholesterol Reduction: Statin Pleiotropy and Peripheral Arterial Disease
Authors: Penton Ashley , A. Langert Kelly , Maier Kristopher , Gahtan Vivian
Published: November 2023

Lower extremity peripheral arterial disease (PAD) is the atherosclerotic obstruction of the lower extremity arteries that can lead to walking impairment, non-healing open wounds, gangrene or limb loss. It is estimated that PAD affects greater than 200 million people worldwide and is associated with advanced age, tobacco use, diabetes, hypertension, and hypercholesterolemia. Initial management of PAD involves risk factor modification and pharmacologic strategies, including the implementation of statin therapy. Statins, the most commonly used cholesterol lowering medications, also have beneficial pleiotropic (cholesterol independent) effects including improved patency rates from vascular reconstruction, decreased risk of stroke, myocardial infarction and improved survival. In this chapter, we will discuss the relevant clinical trials, prospective observation and retrospective studies that exemplify the effect of statins on PAD. We will then focus on statin’s cellular effects on endothelial and vascular smooth muscle cell function by examining effects on plaque progression, intimal hyperplasia, re-endothelialization, and angiogenesis/arteriogenesis.
Methodological proposal for the standardization of the Electronic Navigational Chart scheme in the Caribbean Sea
Authors: Bonfante Olga , Torres Parra Rafael Ricardo , Castillo Julio
Published: November 2023

Since the approval of the use of Electronic Navigational Charts (ENC) as equivalent to paper nautical charts, hydrographic services worldwide began their production following existing cartographic schemes. This paper proposes to standardize ENC production schemes at the regional scale through a regular grid system, which unifies the scale of compilation and cell size by navigational purpose. The implementation of this system requires defining the origin of the grid and facilitates the nomenclature of the ENCs. Additionally, this standardization would help for the harmonized production of ENCs by improving their coverage. The proposed methodology is used to formulate an ENCs scheme in the Caribbean Sea, which is part of the Meso American and Caribbean Sea Regional Hydrographic Commission, in order to show its application and advantages. For this region it is proposed to generate a regular grid scheme with cell sizes and compilation scales (1:K) for Overview, General and Coastal navigational purposes of 24° × 24°, 6° × 6° and 1.5° × 1.5° and 1:3,000, 1:700 and 1:180 respectively, which allows to eliminate irregularities between the ENCs. This proposal contributes to the safety of maritime activities, seeking to enhance the quality of the ENC products in this region and increase trust to Electronic Chart Display and Information System users through enhanced visualization and seamless transition between ENCs of the same compilation scale. Additional serves as input for the modernization of the ENC schemes in the different Regional Hydrographic Commissions of the International Hydrographic Organization.