bluuebunny/crossref_metadata_2025 huggingface dataset:
Rancang Bangun Sistem Penggajian Pegawai Politeknik Kediri
Authors: Ari Kuswinda  , Wahyuni Sofiana  , Andika Kurnia Adi Pradana  , Rudy Ariyanto
Published: December 2023

Sistem Penggajian Pegawai Politeknik Kediri dapat dipergunakan sebagai alat bantu dalam melakukan pengelolaan gaji pegawai dan membantu menyediakan informasi mengenai gaji pegawai dengan mudah dan cepat, karena Sistem Penggajian Pegawai Politeknik Kediri ini berbasis web. Aplikasi Sistem Penggajian Pegawai Politeknik Kediri ini dirancang dan dibuat dengan bahasa pemrograman PHP dan diakses menggunakan web browser melalui jaringan internet. Setelah aplikasi ini dibuat kemudian dilakukan percobaan dan pengkajian melalui beberapa tahapan. Antara lain uji coba aplikasi melalui web browser komputer. Dengan adanya Sistem Penggajian Pegawai Politeknik Kediri ini, akan menjadikan kinerja pegawai Politeknik Kediri lebih efisien. Baik pengelolaan data ataupun penyampaian laporan penggajian pegawai, karena dapat diakses melalui jaringan internet.
Perancangan dan Pembuatan Aplikasi E-Learning Menggunakan CMS Moodle
Authors: Muhamad Aslam Amzazka  , Fadelis Sukya  , Yan Watequlis
Published: December 2023

Banyak perguruan tinggi masih menggunakan sistem manual dalam pembelajaran dan menggunakan media kertas. Hal tersebut mengakibatkan pencarian data sulit dilakukan dan memerlukan banyak waktu. Oleh karenanya perlu dibangun kelas virtual yang memiliki fasilitas untuk mengelola materi, manajemen tugas dan nilai secara digital. Sistem ini dibangun dengan menggunakan bahasa pemrograman PHP dan menggunakan database mysql. Terdapat beberapa fitur. Antara lain: kegiatan perkuliahan, perekaman data mahasiswa, pengumpulan tugas, dan pemberian nilai tugas. Pada aplikasi kelas virtual ini belum terdapat fitur kuisioner, dan hanya dapat menangani penilaian tugas saja. Saran untuk pengembangan aplikasi yakni dengan membarikan fitur video chating, kuisioner, dan pemberian nilai selain nilai tugas.
Sistem Manajemen Aset Sekolah
Authors: Benni Agung Nugroho
Published: December 2023

Suatu sekolah tidak lepas dari keberadaan aset yang dimiliki, oleh karena itu diperlukan sebuah sistem yang dapat membantu menangani pedataan aset yang dimiliki oleh suatu sekolah. Selain itu sekolah tersebut juga belum memiliki sebuah sistem yang digunkan untuk mendata aset sekolah dengan cepat dan mudah. Pendataan aset yang selama ini dilakukan masih menggunakan cara manual yaitu mencatat data aset yang dimiliki dalam pembukuan, sehingga cara tersebut kurang mempunyai kemudahan dalam pendataan asetnya, karena hal yang tidak dinginkan bisa terjadi sewaktu-waktu. Sistem ini dibuat dengan menggunakan bahasa pemrograman PHP untuk rancangan antar muka dan MySQL untuk mengelola basis data. Pengolahan data pada sistem ini meliputi data login, data master, data entry, dan pelaporan data aset yang terdiri dari proses masukkan data,ubah data master dan data entry, dan hapus data master dan entry. Selain itu ditampilkan juga laporan yang dapat dilihat langsung pada sistem dan juga dapat dicetak. Rancangan bangun sistem ini telah disesuaikan dengan kebutuhan dalam pendataan aset. Rancangan bangun sistem ini hanya dapat diakses oleh kepala yayasan selaku pemilik dana untuk sekolah tersebut, dapat melihat laporan data aset, dan juga dapat mencetak laporan.
Aplikasi Personal Finance Management (Droiduit) Berbasis Android
Authors: Sbastian Terry Pratama  , Fery Sofian Efendi  , Fadelis Sukya
Published: December 2023

Aplikasi personal finance management atau nama dengan nama aplikasi DROIDUIT ini merupakan salah satu aplikasi smartphone android yang mempunyai peranan cukup penting dalam personal. Aplikasi tersebut dibuat untuk memberikan kemudahan dalam mencatat setiap transaksi seperti pencatatan pengeluaran dan pemasukan pada umumnya. Dengan menggunakan aplikasi personal finance management ini akan menambah fitur untuk meminimalisir kesalahan atau kelalaian pada saat melakukan proses transasksi pencatanan keuangan. Ada beberapa tools yang digunakan selama proses pembuatan Aplikasi personal finance management (droiduit) ini antara lain: SQLite dan Android java framework. Aplikasi personal finance management ini mempunyai fitur seperti tambah transaksi pemasukan dan pengeluaran, tambah foto transaksi, fitur reminder atau pengingat transaksi melihat transaksi pencatatan per hari,perbulan, dan sesuai kategori yang di inginkan, fitur-fitur tersebut di gunakan agar dapat meminimalisir kendala atau kesalahan dalam proses transaksi personal, sehingga dapat meningkatkan kemampuan personal dalam.
Informasi Lowongan Kerja Berbasis Android (Studi Kasus di Disnaker Kab.Nganjuk)
Authors: Benni Agung Nugroho
Published: December 2023

Lowongan pekerjaan adalah Sebuah kesempatan kerja pada posisi tertentu di instansi atau tempat usaha yang tersedia untuk individu maupun kelompok yang telah memenuhi persyaratan yang dibutuhkan. Oleh karena itu dirancang dan dibuatnya aplikasi informasi lowongan pekerjaan berbasis android dengan studi kasus di Disnaker kab. Nganjuk. Analisa kebutuhan aplikasi informasi lowongan pekerjaan berbasis android disusun melalui wawancara dengan Disnaker Kab. Nganjuk dan pencarian data di internet. Aplikasi memiliki dua pengguna yakni admin dan pengunjung atau calon pelamar kerja. Fitur aplikasi memiliki data admin, data kategori, data perusahaan , data pengumuman dan data pelamar kerja. Untuk data pelamar dihasilkan dari data pelamar kerja yang telah mendaftarkan diri sebagai calon pekerja pada instansi atau perusahaan yang terkait. Untuk perbaikan dalam penelitian selanjutnya dapat ditambahkan server penyimpanan berkas data pelamar yang nantinya dapat mengirimkan ke email instansi atau perusahaan secara otomatis.
Aplikasi Realisasi Pencapaian Pembangunan Berbasis GIS
Authors: Agustono Heriadi
Published: December 2023

Kabupaten Kediri sekarang sedang gencar melakukan pembangunan fisik. Saat ini pendataan pembangunan yang ada masih sangat sederhana, yaitu mencatat data menggunakan aplikasi pengolah kata atau lembar bentang. Untuk memudahkan dalam proses pendataan diperlukan sebuah aplikasi yang dapat menyimpan dan menampilkan informasi pembangunan kepada masyarakat yang bertujuan meningkatkan partisipasi masyarakat dalam pembangunan. Oleh karena itu dalam penelitian diangkat topik Aplikasi Realisasi Pencapaian Pembangunan Berbasis GIS. Metodologi yang digunakan mulai dari pengumpulan data melalui observasi, analisa rancangan sistem, rancangan sistem, desain antarmuka, implementasi dan uji coba. Tools yang digunakan dalam membangun aplikasi ini menggunakan bahasa pemrograman PHP dan Framework CodeIgniter dengan basis data pendukung MySQL. Teknologi yang digunakan dalam pengerjaan sistem ini yaitu Google Maps API yang berfungsi untuk menampilkan peta pada aplikasi realisasi pencapaian pembangunan. Hasil akhir dari penelitian ini berupa Aplikasi Realisasi Pencapaian Pembangunan Berbasis GIS. Aplikasi ini memiliki 3 pengguna yaitu admin BPMPD, kepala BPMPD dan masyarakat. Aplikasi ini memiliki fitur mengelola data realisasi pencapaian pembangunan, menampilkan informasi menggunakan peta dengan metode Google Map, serta informasi dalam bentuk grafik. Pada penelitian selanjutnya perlu ditambahkan fitur form usulan untuk masyarakat agar masyarakat tidak hanya melihat data pembangunan namun dapat melakukan usulan dan saran agar tercapainya pembangunan yang baik.
Rancang Bangun Web Profil P3M
Authors: Benni Agung Nugroho  , Ellya Nurfarida
Published: December 2023

Website profil P3M Politeknik Kediri dibuat untuk memperkenalkan visi, misi, RIP , Renstra Pengabdian kepada masyarakat dan menyajikan data profil dosen maupun data penelitian dan pengabdian kepada masyarakat. Dengan demikian maka tugas dari seorang admin P3M Politeknik Kediri semakin mudah untuk dilaksanakan dalam hal membuat rekapitulasi laporan penelitian, dan pengabdian masyarakat setiap tahunnya. Website profil P3M Politeknik Kediri dibangun sesuai dengan kebutuhan fungsional maupun kebutuhan non fungsional dari P3M Politeknik Kediri. Website profil P3M Politeknik Kediri dibangun dengan menggunakan PHP, CSS bootstrap dan basis data MySQL. Tahapan dari pembuatan aplikasi ini adalah tahap perencanaan, analisis, perancangan dan implementasi. Hasil dari penelitian ini adalah terbentuknya sebuah aplikasi berbasis web yang dapat menampilak profil P3M Politeknik Kediri secara umum serta visi, misi, RIP dan renstra pengabdian kepada masyarakat. Kata Kunciâ website profil, P3M Politeknik Kediri, CSS bootstrap, PHP.
Pemetaan Volume Kendaraan di Wilayah Kota Kediri Menggunakan Sistem Informasi Geografis Berbasis Web
Authors: Ashafidz Fauzan Dianta  , Rinanza Zulmy Alhamri
Published: December 2023

Kota Kediri terletak di provinsi Jawa Timur, jumlah penduduknya menurut data BPS (Badan Pusat Statistik) sebesar 267.310 jiwa pada sensus tahun 2013. Semakin hari jumlah penduduk semakin bertambah begitupun juga dengan jumlah kendaraan, baik sepeda motor, mobil, maupun kendaraan berat juga semakin bertambah. Data volume diolah oleh Dinas Perhubungan Kota Kediri secara manual dengan penyajian dalam bentuk tabel dan grafik. Data ini digunakan sebagai acuan untuk merekayasa lalu lintas agar kemacetan tidak terjadi di beberepa ruas jalan. Penelitian ini bertujuan untuk membuat sebuah sistem informasi berbasis web yang dapat menampilkan penyebaran jumlah volume kendaraan disetiap ruas jalan di wilayah Kota Kediri. Dengan pengamatan pola penyebaran volume kendaraan berbasis web-GIS ini, maka pemangku kebijakan dapat menganalisis dan mengambil sebuah kebijakan dalam perencanaan rekayasa lalu lintas dengan akurat. Metode yang digunakan untuk penelitian ini adalah menganalisa kebutuhan sistem, merancang sistem, dan mengimplementasikan program dengan menggunakan pemetaan Google Maps API dan bahasa pemrograman PHP serta database MySQL. Hasil penelitian ini adalah sebuah aplikasi GIS berbasis web yang dapat memvisualisakan data volume kendaraan disetiap ruas jalan di wilayah Kota Kediri
Salmonella enterica and outer membrane vesicles are current and future options for cancer treatment
Authors: Pérez Jorge Genesy , Gontijo Marco Túlio Pardini , Brocchi Marcelo
Published: December 2023

Conventional cancer therapies have many limitations. In the last decade, it has been suggested that bacteria-mediated immunotherapy may circumvent the restrictions of traditional treatments. For example, Salmonella enterica is the most promising bacteria for treating cancer due to its intrinsic abilities, such as killing tumor cells, targeting, penetrating, and proliferating into the tumor. S. enterica has been genetically modified to ensure safety and increase its intrinsic antitumor efficacy. This bacterium has been used as a vector for delivering anticancer agents and as a combination therapy with chemotherapy, radiotherapy, or photothermic. Recent studies have reported the antitumor efficacy of outer membrane vesicles (OMVs) derived from S. enterica. OMVs are considered safer than attenuated bacteria and can stimulate the immune system as they comprise most of the immunogens found on the surface of their parent bacteria. Furthermore, OMVs can also be used as nanocarriers for antitumor agents. This review describes the advances in S. enterica as immunotherapy against cancer and the mechanisms by which Salmonella fights cancer. We also highlight the use of OMVs as immunotherapy and nanocarriers of anticancer agents. OMVs derived from S. enterica are innovative and promising strategies requiring further investigation.
Performance and sustainability evaluation of rural digitalization and its driving mechanism: evidence from Hunan province of China
Authors: Xing Zhipeng , Zhao Sidong , Wang Di
Published: December 2023

Quantitatively measuring rural digitalization performance and development sustainability, identifying their key influencing factors and figuring out their driving mechanisms are of great value to policy design for rural revitalization and management. This paper analyzed the sustainable development degree, spatial patterns, and influencing factors of rural digitization in Hunan Province, China, based on a combination of PSR, TOPSIS, ESDA, GWR and GeoDetector, in an attempt to provide a basis for the planning and policy design of rural management. The sustainability and construction performance of rural digitalization in Hunan were characterized by significant spatial inequality and positive autocorrelation, with coefficients of variation of 0.33 and 0.24, and Moran’s I values of 0.29 and 0.34, respectively. The rural digitalization in Hunan showed significant non-equilibrium across different dimensions and brought forward diversified combination patterns, including single dimensional leadership, dual dimensional leadership, three-dimensional leadership, and all-round development. The pattern dual dimensional leadership, especially PS (pressure + state), was dominant in the sustainability of rural digitalization, compared to the pattern single dimensional leadership dominant in the construction performance, especially I (rural infra-structure digitalization), IL (rural infrastructure + life digitalization), IG (rural infrastructure + governance digitalization). The sustainability and construction performance of rural digitalization in Hunan were subject to a complex driving mechanism, with different factors differing significantly in their action nature, force, spatial effects and interactions. Notably, economic development (gross domestic product) is a positive key factor, while government intervention capacity (fiscal self-sufficiency rate) is an important factor, and natural environment (relief amplitude) is a mixed auxiliary factor (both positive and negative). Factor interactions were mainly characterized by nonlinear enhancement and a large number of super factor pairs. Therefore, the policy design should take into account both localized and differentiated management; and also emphasize enhanced cooperation with adjacent counties and synergistic management. It is suggested to divide Hunan into four planning zonings of leading, potential, warning and general zone, and design the spatial policies for each of them according to the driving mechanism, so as to develop a more reasonable and practical combination of development projects and management policies.
Phylogenomics and systematics of botryllid ascidians, and implications for the evolution of allorecognition
Authors: Nydam Marie L. , Lemmon Alan R. , Lemmon Emily M. , Ziegler Kevin , Cohen C. Sarah , Palomino-Alvarez Lilian A. , Gissi Carmela
Published: December 2023

Allorecognition, the ability of an organism to distinguish kin from non-kin, or self from non-self, has been studied extensively in a group of invertebrate chordates, the colonial ascidians called botryllids (Subphylum Tunicata, Class Ascidiacea, Family Styelidae). When two conspecific botryllid colonies come in contact, there are two potential outcomes to an allorecognition reaction: fusion or rejection. The rejection outcome of allorecognition varies by species, and has been classified by type (referred to as R-Type). R-Type is defined according to how far the fusion process progresses before the rejection begins, since the rejection reaction appears as an interference of the fusion process. Here, we map the evolution of R-Types onto an extended and robust phylogeny of the botryllids. In this study, we have reconstructed the largest phylogenomic tree of botryllids, including 97 samples and more than 40 different species, and mapped on it nine of the 13 species for which the R-Type is known. Based on the R-Type known in a single outgroup species (Symplegma reptans), we infer that at least R-Type B and E-like could be ancestral to the Botrylloides/Botryllus group. However, the application of ancestral character state reconstructions does not provide conclusive results since several clades show more than one equiparsimonious R-Type state. Notably, all R-Type A species are clustered together and certainly evolved later than other R-Types. Our phylogenomic tree has been built on 177 nuclear loci and nearly all clades are well supported. Moreover, our phylogenetic analyses also take into account the results of species delimitation analyses based on the mitochondrial COI gene and of careful morphological analyses of the samples. The implementation of this integrated taxonomic approach, combining morphological as well as nuclear and mitochondrial data, has allowed the description of six new species, and the identification of a number of putative unnamed taxa. Thus, our results also demonstrate the existence of an unexplored hidden diversity within botryllids.
Seventy-two models of large mammal connectivity across Panama: insights into a critical biogeographic linkage zone
Authors: Cushman Samuel A. , Craighead Kimberly A. , Yacelga Milton , Kaszta Zaneta M. , Wan Ho Yi , Macdonald David W.
Published: December 2023

Aim

The goal of this study was to evaluate consistency among multiple connectivity models for jaguar and puma across Panama to evaluate the plausible current patterns of habitat connectivity for these and potentially other species in this critical biogeographic linkage zone.

Approach

We compared 72 different models of landscape connectivity for both large felids using both empirically based and expert opinion derived resistance layers. We conducted resistant kernel modeling with different dispersal abilities to reflect uncertainty in the movement potential of the two species. We applied three transformations to the resulting connectivity surfaces to account for uncertainty about the shape of the dispersal kernel function. We then evaluated the similarities and differences among these connectivity models, identifying several factors that drive their differences. We quantified the factors that drive differences in connectivity predictions using surface correlation, Mantel testing, and agglomerative hierarchical clustering.

Results

We found that the main differences among predicted connectivity surfaces were related to species and resistance modeling approach, with relatively little consistent difference related to dispersal ability and nonlinear kernel transformation. Based on the ensemble connectivity prediction across the 72 models, we identified two major core areas, corresponding to the eastern and western portions of the central mountain range, significant attenuation of connectivity in lowland and developed areas of Panama, a major breakage in connectivity in the Canal Zone spanning the width of the country, and weak but potentially critical movement routes connecting the two core areas across the Canal Zone.

Implications

This paper contributes to both a theoretical and practical understanding of the functional connectivity of large felids, confirming the strong effect of differences in source points and resistance surfaces on connectivity predictions and identifying and mapping key core areas, barriers, and potential corridors for carnivore movement across the critical Pan-American linkage of the Isthmus of Panama.
Signal regulatory protein beta 2 is a novel positive regulator of innate anticancer immunity
Authors: Visser Nienke , Nelemans Levi Collin , He Yuan , Lourens Harm Jan , Corrales Macarena González , Huls Gerwin , Wiersma Valerie R. , Schuringa Jan Jacob , Bremer Edwin
Published: December 2023

In recent years, the therapeutic (re)activation of innate anticancer immunity has gained prominence, with therapeutic blocking of the interaction of Signal Regulatory Protein (SIRP)-α with its ligand CD47 yielding complete responses in refractory and relapsed B cell lymphoma patients. SIRP-α has as crucial inhibitory role on phagocytes, with e.g., its aberrant activation enabling the escape of cancer cells from immune surveillance. SIRP-α belongs to a family of paired receptors comprised of not only immune-inhibitory, but also putative immune-stimulatory receptors. Here, we report that an as yet uninvestigated SIRP family member, SIRP-beta 2 (SIRP-ß2), is strongly expressed under normal physiological conditions in macrophages and granulocytes at protein level. Endogenous expression of SIRP-ß2 on granulocytes correlated with trogocytosis of cancer cells. Further, ectopic expression of SIRP-ß2 stimulated macrophage adhesion, differentiation and cancer cell phagocytosis as well as potentiated macrophage-mediated activation of T cell Receptor-specific T cell activation. SIRP-ß2 recruited the immune activating adaptor protein DAP12 to positively regulate innate immunity, with the charged lysine 202 of SIRP-ß2 being responsible for interaction with DAP12. Mutation of lysine 202 to leucine lead to a complete loss of the increased adhesion and phagocytosis. In conclusion, SIRP-ß2 is a novel positive regulator of innate anticancer immunity and a potential costimulatory target for innate immunotherapy.
The enrichment of the gut microbiota Lachnoclostridium is associated with the presence of intratumoral tertiary lymphoid structures in hepatocellular carcinoma
Authors: Zhao Rui , Li Jiacheng , Chen Bo , Zhao Jungang , Hu Leyin , Huang Kate , Chen Qiwen , Yao Jiangqiao , Lin Ganglian , Bao Lishimeng , Lu Mengmeng , Wang Yi , Chen Gang , Wu Fang
Published: December 2023

Backgrounds and aims

Immunotherapies have formed an entirely new treatment paradigm for hepatocellular carcinoma (HCC). Tertiary lymphoid structure (TLS) has been associated with good response to immunotherapy in most solid tumors. Nonetheless, the role of TLS in human HCC remains controversial, and recent studies suggest that their functional heterogeneity may relate to different locations within the tumor. Exploring factors that influence the formation of TLS in HCC may provide more useful insights. However, factors affecting the presence of TLSs are still unclear. The human gut microbiota can regulate the host immune system and is associated with the efficacy of immunotherapy but, in HCC, whether the gut microbiota is related to the presence of TLS still lacks sufficient evidence.

Methods

We performed pathological examinations of tumor and para-tumor tissue sections. Based on the location of TLS in tissues, all patients were divided into intratumoral TLS (It-TLS) group and desertic TLS (De-TLS) group. According to the grouping results, we statistically analyzed the clinical, biological, and pathological features; preoperative gut microbiota data; and postoperative pathological features of patients.

Results

In a retrospective study cohort of 60 cases from a single center, differential microbiota analysis showed that compared with the De-TLS group, the abundance of Lachnoclostridium, Hungatella, Blautia, Fusobacterium, and Clostridium was increased in the It-TLS group. Among them, the enrichment of Lachnoclostridium was the most significant and was unrelated to the clinical, biological, and pathological features of the patients. It can be seen that the difference in abundance levels of microbiota is related to the presence of TLS.

Conclusion

Our findings prove the enrichment of Lachnoclostridium-dominated gut microbiota is associated with the presence of It-TLS in HCC patients.
Genotype analysis to clarify RhD variants in discrepant samples of Chilean population
Authors: Aburto Andrés , Zapata Diego , Retamales Eduardo , Fernández Jorge , Barra Gisselle , Peña Francisca , Cárcamo Sofía , Saavedra Nicolás , Sandoval Cristian , Orellana Juan , Caamaño José
Published: December 2023

Introduction

The D antigen variants are classified as weak, partial, and extremely weak (DEL) and can be differentiated using molecular tests. In Chile, the laboratories of local blood centers do not identify variants of the D antigen, referring them for study to the Reference Laboratory of the Public Health Institute of Chile. So, our aim was to talk about the results of the molecular analysis of variants of the D antigen in samples that had different results in the serological classification.

Methods

In the D antigen classification of the Rh system, 479 samples with serological discrepant results were sent for molecular analysis. The Rh phenotype was performed with monoclonal anti-C, anti-c, anti-E, and anti-e antisera by direct agglutination. To find the D antigen, researchers used direct agglutination with monoclonal antisera and indirect antiglobulin testing with the column (gel) agglutination method. Molecular analysis was performed with a polymerase chain reaction with sequence-specific primers (SSP-PCR) and sequencing.

Results and discussion

The presence of D antigen variants was confirmed in 332 samples (69.3%), with an initial discrepancy in serological classification. In this group of discrepant samples, the frequency of weak RhD variants was 66% (219/332), that of extremely weak RhD was 28% (93/332), and that of partial RhD was 6% (20/332). The weak variants type 2 (27.4%), type 3 (8.4%), type 48 (8.4%), and type 1 (8.1%) were the next most prevalent variants after RHD*DEL43 (28%). The ccEe (R2r) phenotype was the most frequently detected (38.4%) and is present in 87% of the RHD*DEL43 samples. The E antigen is associated with the presence of this variant. Our analyses give the first description of D antigen variants in Chile. The most common variants are DEL type (RHD*DEL43) and weak (weak type 2), which are linked to the ccDEe (R2r) phenotype. These findings allow us to characterize the variants of the D antigen in Chile and, according to the obtained data, to design strategies for the management of donors, patients, and pregnant women.
Non-linear long-term trend in volume transport through the Korea/Tsushima Strait
Authors: Moon Jae-Hong , Jang Hyunjun , Kim Taekyun , Cha Hyeonsoo , Hirose Naoki
Published: December 2023

Based on the relation between volume transport and sea level difference across the Korea/Tsushima Strait (KTS), in this study, we estimated the volume transport of the Tsushima Warm Current over the past four decades and examined its long-term trend using an ensemble empirical model decomposition (EEMD) method. The estimated geostrophic transports showed very good agreement with those measured by acoustic Doppler current profiler and those estimated from satellite altimetry-based sea level data. This corroborates the reliability of the long-term estimation. EEMD analysis revealed an acceleration in volume transport in the KTS, with a persistent increase in the trend rate occurring after the mid-1980s. Further analyses indicate that the trend shift in the KTS closely coincided with an upper-ocean warming trend in the East/Japan Sea (EJS) after the mid-1980s. Analyzing large-scale wind patterns suggests that long-term trends of wind stress curls over the North Pacific are likely a key driver of the trend shifts in the inflow through the KTS and the upper-ocean warming in the EJS over the past four decades.
Study on the eco-economic efficiency of China’s mariculture based on undesirable output
Authors: Jinli Dong , Manhong Shen , Xuan Yu
Published: December 2023

The marine ecological and environmental problems caused by the mariculture industry have drawn considerable attention. The Slacks-based measure (SBM) model was applied to measure the eco-economic efficiency of China’s mariculture industry from 2011 to 2020, where the nitrogen and phosphorus pollutants produced in the mariculture process were the non-desired outputs. The results indicated that the average value of mariculture eco-economic efficiency in different provinces of China was above 0.8 in the higher status. The σ and β convergence analysis verified that the differences in the eco-economic efficiency of mariculture in coastal provinces of China were shrinking significantly (P = 0.017 and 0.000, respectively). There are imbalances in regions as the change of the East China Sea and the South China Sea showed an approximately “U” shaped state. The Chinese government should continue to strengthen its economic and policy support for mariculture to ensure its long-term green and healthy development in a long time.
Diversity and community composition of strictly anaerobic and culturable bacteria from the feces of Styrofoam-fed Tenebrio molitor larvae: a culturomics-based study
Authors: Zhu Junyu , Chen Xiaochen , Chen Sheng-Chung , Qiu Wanling , Yu Jianying , Guo Tengfei , Wang Xianxing
Published: December 2023

Introduction

In recent years, researchers have been exploring the plastic-degrading abilities of bacteria residing in the guts of Styrofoam-eating Tenebrio molitor larvae. However, none of the reported strains have displayed highly efficient plastic degradation capabilities, and it’s noteworthy that none of the existing studies have focused on strictly anaerobic microbes.

Methods

In this study, we exclusively fed Styrofoam to T. molitor larvae and examined how this dietary change influence the gut’s bacterial community composition, as observed through fecal bacteria using bacterial 16S rRNA gene amplicon sequencing and the small-scale culturomics method with 20 types of anaerobic media under four different conditions.

Results

The results revealed a significant shift in the dominant phylogroup from Lactococcus (37.8%) to Escherichia–Shigella (54.7%) when comparing the feces of larvae fed with bran and Styrofoam, as analyzing through the bacterial 16S rRNA gene amplicon sequencing. For small-scale culturomics method, a total of 226 strains of anaerobic bacteria were isolated and purified using the rolling-tube/strictly anaerobic technique. Among them, 226 strains were classified into 3 phyla, 7 classes, 9 orders, 17 families, 29 genera, 42 known species and 34 potential novel species.

Discussion

Interestingly, 24 genera in total, identified through the culturomics method, were not found in the results obtained from amplicon sequencing. Here, we present a collection of culturable anaerobic bacteria from the feces of T. molitor larvae, which might be a promising avenue for investigating the biodegradability of plastics by combining specific strains, either randomly or intentionally, while considering the abundance ratio of the microbial community composition.
Patterns of attentional bias in antenatal depression: an eye-tracking study
Authors: Xu Yao , Zheng Peiwen , Feng Wenqian , Chen Lipeng , Sun Shiyu , Liu Jie , Tang Weina , Bao Ciqing , Xu Ling , Xu Dongwu , Zhao Ke
Published: December 2023

Introduction

One of the most common mental disorders in the perinatal period is depression, which is associated with impaired emotional functioning due to alterations in different cognitive aspects including thought and facial emotion recognition. These functional impairment may affect emerging maternal sensitivity and have lasting consequences for the dyadic relationship. The current study aimed to investigate the impact of depressive symptoms on the attention bias of infant stimuli during pregnancy.

Methods

Eighty-six pregnant women completed the Edinburgh Postnatal Depression Scale and an eye-tracking task comprising infant-related emotion images. All participants showed biased attention to infant-related images.

Results

First, compared to healthy pregnant women, pregnant women with depression symptoms initially directed their attention to infant-related stimuli more quickly (F (1, 84) = 6.175, p = 0.015, η2 = 0.068). Second, the two groups of pregnant women paid attention to the positive infant stimuli faster than the neutral infant stimuli, and the first fixation latency bias score was significantly smaller than that of the infant-related negative stimulus (p = 0.007). Third, compared with the neutral stimulus, the non-depression group showed a longer first gaze duration to the negative stimulus of infants (p = 0.019), while the depressive symptoms group did not show this difference.

Conclusion

We speculate that structural and functional changes in affective motivation and cognitive-attention brain areas may induce these attentional bias patterns. These results provide suggestions for the implementation of clinical intervention programs to correct the attention bias of antenatal depressed women.
Enabling knowledge translation: implementation of a web-based tool for independent walking prediction after traumatic spinal cord injury
Authors: Hakimjavadi Ramtin , Hong Heather A. , Fallah Nader , Humphreys Suzanne , Kingwell Stephen , Stratton Alexandra , Tsai Eve , Wai Eugene K. , Walden Kristen , Noonan Vanessa K. , Phan Philippe
Published: December 2023

Introduction

Several clinical prediction rules (CPRs) have been published, but few are easily accessible or convenient for clinicians to use in practice. We aimed to develop, implement, and describe the process of building a web-based CPR for predicting independent walking 1-year after a traumatic spinal cord injury (TSCI).

Methods

Using the published and validated CPR, a front-end web application called “Ambulation” was built using HyperText Markup Language (HTML), Cascading Style Sheets (CSS), and JavaScript. A survey was created using QualtricsXM Software to gather insights on the application's usability and user experience. Website activity was monitored using Google Analytics. Ambulation was developed with a core team of seven clinicians and researchers. To refine the app's content, website design, and utility, 20 professionals from different disciplines, including persons with lived experience, were consulted.

Results

After 11 revisions, Ambulation was uploaded onto a unique web domain and launched (www.ambulation.ca) as a pilot with 30 clinicians (surgeons, physiatrists, and physiotherapists). The website consists of five web pages: Home, Calculation, Team, Contact, and Privacy Policy. Responses from the user survey (n = 6) were positive and provided insight into the usability of the tool and its clinical utility (e.g., helpful in discharge planning and rehabilitation), and the overall face validity of the CPR. Since its public release on February 7, 2022, to February 28, 2023, Ambulation had 594 total users, 565 (95.1%) new users, 26 (4.4%) returning users, 363 (61.1%) engaged sessions (i.e., the number of sessions that lasted 10 seconds/longer, had one/more conversion events e.g., performing the calculation, or two/more page or screen views), and the majority of the users originating from the United States (39.9%) and Canada (38.2%).

Discussion

Ambulation is a CPR for predicting independent walking 1-year after TSCI and it can assist frontline clinicians with clinical decision-making (e.g., time to surgery or rehabilitation plan), patient education and goal setting soon after injury. This tool is an example of adapting a validated CPR for independent walking into an easily accessible and usable web-based tool for use in clinical practice. This study may help inform how other CPRs can be adopted into clinical practice.
Frontal lobe epilepsy: an eye tracking study of memory and attention
Authors: Zhang Qiong , Sun Weifeng , Huang Kailing , Qin Li , Wen Shirui , Long Xiaoyan , Wang Quan , Feng Li
Published: December 2023

Objective

To explore the characteristics and mechanisms of working memory impairment in patients with frontal lobe epilepsy (FLE) through a memory game paradigm combined with eye tracking technology.

Method

We included 44 patients with FLE and 50 healthy controls (HC). All participants completed a series of neuropsychological scale assessments and a short-term memory game on an automated computer-based memory evaluation platform with an eye tracker.

Results

Memory scale scores of FLE patients including digit span (U = 747.50, p = 0.007), visual recognition (U = 766.50, p = 0.010), and logical memory (U = 544.00, p < 0.001) were significantly lower than HC. The patients with FLE took longer to complete the four levels of difficulty of the short-term memory game than healthy controls (level 1: U = 2974.50, p = 0.000; level 2: U = 3060.50, p = 0.000; level 3: U = 2465.00, p = 0.000; level 4: U = 2199.00, p = 0.000). During the memory decoding period, first fixation on the targets took significantly longer for FLE patients for all difficulty levels compared to controls (level 1: U = 3407.00, p = 0.008; level 2: U = 3618.00, p = 0.036; level 3: U = 3345.00, p = 0.006; level 4: U = 2781.00, p = 0.000). The average fixation duration per target among patients with FLE was found to be significantly longer compared to HC (level 1: U = 2994.50, p = 0.000; level 2: U = 3101.00, p = 0.000; level 3: U = 2559.50, p = 0.000; level 4: U = 2184.50, p = 0.000). The total fixation duration on AOI/total completion time of FLE patients was significantly lower than those of HC for levels 1 to 3 (level 1: U = 1557.00, p = 0.000; level 2: U = 2333.00, p = 0.000; level 3: U = 2757.00, p = 0.000). Furthermore, the eye tracking data during the memory decoding phase were correlated with neuropsychological scale scores (p < 0.05).

Conclusion

Patients with FLE exhibited short-term memory impairment probably due to deficits in attentional maintenance, especially during the memory decoding phase. Eye tracking technology provided the possibility to help separate and quantify visual attention from memory processing, contributing to exploring underlying mechanisms of memory impairment in FLE.
It’s a TRIM-endous view from the top: the varied roles of TRIpartite Motif proteins in brain development and disease
Authors: Dudley-Fraser Jane , Rittinger Katrin
Published: December 2023

The tripartite motif (TRIM) protein family members have been implicated in a multitude of physiologies and pathologies in different tissues. With diverse functions in cellular processes including regulation of signaling pathways, protein degradation, and transcriptional control, the impact of TRIM dysregulation can be multifaceted and complex. Here, we focus on the cellular and molecular roles of TRIMs identified in the brain in the context of a selection of pathologies including cancer and neurodegeneration. By examining each disease in parallel with described roles in brain development, we aim to highlight fundamental common mechanisms employed by TRIM proteins and identify opportunities for therapeutic intervention.
Role of gonadally synthesized steroid hormones in the colorectal cancer microenvironment
Authors: Wenxuan Liu , Liu Li , Zhang Lilong , Qiu Zhendong , Wu Zhongkai , Deng Wenhong
Published: December 2023

Objective

To understand the relationship between steroid hormones synthesized by the gonads and colorectal cancer as well as its tumor microenvironment, in the expectation of providing new ideas in order to detect and treat colorectal cancer.

Methods

Through reviewing the relevant literature at home and abroad, we summarized that androgens promote the growth of colorectal cancer, and estrogens and progesterone help prevent bowel cancer from developing; these three hormones also have a relevant role in the cellular and other non-cellular components of the tumor microenvironment of colorectal cancer.

Conclusion

The current literature suggests that androgens, estrogens, and progesterone are valuable in diagnosing and treating colorectal cancer, and that androgens promote the growth of colorectal cancer whereas estrogens and progesterone inhibit colorectal cancer, and that, in addition, the receptors associated with them are implicated in the modulation of a variety of cellular components of the microenvironment of colorectal cancer.
Parental preferences for the procedural sedation of children in dentistry: a discrete choice experiment
Authors: Zhuge Jinru , Zheng Dongyue , Li Xingwang , Nie Xin , Liu Jiefan , Liu Ruohai
Published: December 2023

Purpose

The aim of this study was to explore parental preferences for the procedural sedation of children in dentistry through a discrete choice experiment (DCE) to inform clinical decisions and oral health management.

Methods

Based on literature reviews, interviews with parents of pediatric dental patients, and expert consultation, six attributes, including fasting time, recovery time, sedative administration routes, adverse reactions, sedation depth and procedure cost, were incorporated into the DCE questionnaire. The DCE questionnaire collected data on parental preferences for pediatric dental sedation treatment from June to August 2022. A conditional logit model was used to analyze preference and willingness to pay (WTP) for each attribute and its level. Subgroup analyses assessing the impact of parents' dental anxiety on procedural sedation preferences were also conducted using conditional logit models.

Results

A total of 186 valid questionnaires were gathered. Parents' preferences for fewer adverse reactions, a milder sedation depth, lower out-of-pocket cost, shorter fasting and recovery times and administration by inhalation were significantly associated with their choice of sedation model. The conditional logit model showed that parents were most interested in treatments with no adverse reactions (0% vs. 15%) (Coef, 1.033; 95% CI, 0.833–1.233), followed by those providing minimal sedation (vs. deep sedation) (Coef, 0.609; 95% CI, 0.448–0.769). Moreover, the relative importance of adverse reactions and fasting time was higher among anxious than nonanxious parents. The study found a WTP threshold of ¥1,538 for reducing adverse reactions (15% to 0%). The WTP threshold for the best sedation procedure scenario (no fasting requirement, 10 min recovery time, administration by inhalation, 0% adverse reaction incidence and minimal sedation) was ¥3,830.

Conclusion

Reducing the adverse reactions and depth of sedation are predominant considerations for parents regarding procedural sedation in pediatric dentistry, followed by lower cost, shorter fasting and recovery times and inhalation sedation. Parents with dental anxiety had a stronger preference for options with a lower incidence of adverse reactions and shorter fasting time than parents without dental anxiety. This discovery is helpful for doctors and can promote collaborative decision-making among parents and doctors.
Association of antihypertensive drugs with COVID-19 outcomes: a drug-target Mendelian randomization study
Authors: Zhang Kun , Gao Hengxing , Chen Mingwei
Published: December 2023

Background: Observational investigations have provided conflicting results regarding the effect of antihypertensive drugs on the risk of COVID-19 outcomes. We intended to assess the causal effect of antihypertensive drugs on COVID-19 outcomes using drug-target Mendelian randomization (MR), mainly including angiotensin-converting enzyme inhibitors (ACEIs), β-blockers (BBs) and calcium channel blockers (CCBs).

Methods: We used the genetic variants (minor allele frequency >1%, r2 < 0.30) located within 100 k bases of each drug target gene and associated with lower systolic blood pressure (p < 5 × 10−8) as genetic proxies for antihypertensive drugs. COVID-19 outcomes included COVID-19 susceptibility (122,616 cases and 2,475,240 controls), hospitalization (32,519 cases and 206,2805 controls), and severe illness (13,769 cases and 1,072,442 controls). All studies were conducted on populations of European ancestry. MR estimates were generated using an inverse variance weighted (IVW) model.

Results: IVW-MR analysis observed a weak causality between CCBs and COVID-19 susceptibility (OR: 0.993, 95% CI: 0.988–0.999, p = 0.012). Sensitivity analysis suggested that this result was robust. No evidence was found for a link between other antihypertensive drugs and COVID-19 outcomes.

Conclusion: The present study suggests that CCBs may reduce COVID-19 susceptibility in European populations.
Research on weed identification in soybean fields based on the lightweight segmentation model DCSAnet
Authors: Yu Helong , Che Minghang , Yu Han , Ma Yuntao
Published: December 2023

Weeds can compete with crops for sunlight, water, space and various nutrients, which can affect the growth of crops.In recent years, people have started to use self-driving agricultural equipment, robots, etc. for weeding work and use of drones for weed identification and spraying of weeds with herbicides, and the effectiveness of these mobile weeding devices is largely limited by the superiority of weed detection capability. To improve the weed detection capability of mobile weed control devices, this paper proposes a lightweight weed segmentation network model DCSAnet that can be better applied to mobile weed control devices. The whole network model uses an encoder-decoder structure and the DCA module as the main feature extraction module. The main body of the DCA module is based on the reverse residual structure of MobileNetV3, effectively combines asymmetric convolution and depthwise separable convolution, and uses a channel shuffle strategy to increase the randomness of feature extraction. In the decoding stage, feature fusion utilizes the high-dimensional feature map to guide the aggregation of low-dimensional feature maps to reduce feature loss during fusion and increase the accuracy of the model. To validate the performance of this network model on the weed segmentation task, we collected a soybean field weed dataset containing a large number of weeds and crops and used this dataset to conduct an experimental study of DCSAnet. The results showed that our proposed DCSAnet achieves an MIoU of 85.95% with a model parameter number of 0.57 M and the highest segmentation accuracy in comparison with other lightweight networks, which demonstrates the effectiveness of the model for the weed segmentation task.
Identification of Whirly transcription factors in Triticeae species and functional analysis of TaWHY1-7D in response to osmotic stress
Authors: Liu Hao , Wang Xiaoyu , Yang Wenbo , Liu Wenyan , Wang Yanfang , Wang Qin , Zhao Yanhong
Published: December 2023

Osmotic stress poses a threat to the production and quality of crops. Whirly transcription factors have been investigated to enhance stress tolerance. In this study, a total of 18 Whirly genes were identified from six Triticeae species, which were classified into Whirly1 and Whirly2. The exon–intron structure, conserved motif, chromosomal location, collinearity, and regulatory network of Whirly genes were also analyzed. Real-time PCR results indicated that TaWHY1 genes exhibited higher expression levels in leaf sheaths and leaves during the seedling stage, while TaWHY2 genes were predominantly expressed in roots. Under PEG stress, the expression levels of TaWHY1-7A, TaWHY2-6A, TaWHY2-6B, and TaWHY2-6D were increased, TaWHY1-7D was reduced, and TaWHY1-4A had no significant change. All TaWHY genes were significantly up-regulated in response to NaCl stress treatment. In addition, TaWHY1-7A and TaWHY1-7D mainly enhanced the tolerance to oxidative stress in yeast cells. TaWHY2s mainly improved NaCl stress tolerance and were sensitive to oxidative stress in yeast cells. All TaWHYs slightly improved the yeast tolerance to d-sorbitol stress. The heterologous expression of TaWHY1-7D greatly improved drought and salt tolerance in transgenic Arabidopsis. In conclusion, these results provide the foundation for further functional study of Whirly genes aimed at improving osmotic stress tolerance in wheat.