bluuebunny/crossref_metadata_2025 huggingface dataset:
The Epstein-Barr Virus Enhancer Interaction Landscapes in Virus-Associated Cancer Cell Lines
Authors: Ding Weiyue , Wang Chong , Narita Yohei , Wang Hongbo , Leong Merrin Man Long , Huang Alvin , Liao Yifei , Liu Xuefeng , Okuno Yusuke , Kimura Hiroshi , Gewurz Benjamin , Teng Mingxian , Jin Shuilin , Sato Yoshitaka , Zhao Bo
Published: September 2022

EBV is the first human DNA tumor virus identified, discovered over 50 years ago. EBV causes ~200,000 cases of various cancers each year.
Female Antibodies Go the Distance against Influenza Viruses
Authors: Good Marina R. , Guthmiller Jenna J.
Published: September 2022

Females have long been described to generate superior humoral immune responses relative to those in males. In the article by Ursin et al. (R. L. Ursin, S. Dhakal, H. Liu, S. Jayaraman, et al., mBio 13:e01839-22, 2022,
https://doi.org/10.1128/mbio.01839-22
), the authors showed that female mice generated a more robust, broadly reactive, and protective humoral immune response against influenza viruses in comparison to their male counterparts.
Siderophore Immunization Restricted Colonization of Adherent-Invasive Escherichia coli and Ameliorated Experimental Colitis
Authors: Gerner Romana R. , Hossain Suzana , Sargun Artur , Siada Kareem , Norton Grant J. , Zheng Tengfei , Neumann Wilma , Nuccio Sean-Paul , Nolan Elizabeth M. , Raffatellu Manuela
Published: September 2022

Adherent-invasive
Escherichia coli
(AIEC) is abnormally prevalent in patients with ileal Crohn’s disease and exacerbates intestinal inflammation, but treatment strategies that selectively target AIEC are unavailable. Iron is an essential micronutrient for most living organisms, and bacterial pathogens have evolved sophisticated strategies to capture iron from the host environment.
Draft Genome Sequence of Lactobacillus brevis Strain 2-34, Isolated from the Shaoxing Huangjiu Fermentation Process
Authors: Li Xuemei , Li Chenghao , Mi Qili , Dong Gaofeng , Gao Qian , Li Xiaomin
Published: September 2022

Here, we announce the draft genome sequence of
Lactobacillus brevis
2-34, a strain isolated from the fermentation process of Shaoxing huangjiu (Chinese rice wine). The genome size of 2-34 was 2,557,496 bp, with 2,459 coding genes, 67 tRNAs, and 2 rRNAs.
Draft Genome Sequence of Pseudomonas aeruginosa AS_23, Isolated from Petroleum-Contaminated Soil in Delta State, Nigeria
Authors: Kutshik Richard J. , Okenmor Grace A. , Longdet Ishaya Y.
Published: September 2022

Pseudomonas aeruginosaAS_23 was isolated from petroleum-contaminated soil in Nigeria. Here, we present the draft genome sequence, consisting of an 6,760,157-bp genome with 6,348 protein-coding sequences, 6,253 functionally assigned genes, and 61 RNA genes. Average nucleotide identity-based whole-genome comparisons suggest that this is a new strain ofPseudomonas aeruginosa.
Complete Coding Genome Sequence of an Influenza A/H3N8 Equine Virus Isolated in Kazakhstan in 2007
Authors: Burashev Yerbol , Orynbayev Mukhit , Zakarya Kunsulu , Abduraimov Yergali , Kassenov Markhabat , Strochkov Vitaliy , Kozhabergenov Nurlan , Usserbayev Bekbolat , Melisbek Aibarys , Shirinbekov Meirzhan , Sypatay Nuradyl , Sultankulova Kulyaisan
Published: September 2022

Here, we reported the complete coding sequence of the influenza A/equine/Otar/3/2007 (H3N8) equine virus, first isolated in Kazakhstan in 2007. The hemagglutinin (HA) sequences of the Kazakhstan isolates appeared to be closely related to viruses isolated in early 2000 in Asia. Phylogenetic analysis characterized the Kazakhstan isolates as a member of the Florida sublineage clade 2 by the HA protein sequence.
Potent
In Vitro
and
Ex Vivo
Anti-Gonococcal Activity of the RpoB Inhibitor Corallopyronin A
Authors: Edwards Jennifer L. , Balthazar Jacqueline T. , Esposito Danillo L. A. , Ayala Julio C. , Schiefer Andrea , Pfarr Kenneth , Hoerauf Achim , Alt Silke , Hesterkamp Thomas , Grosse Miriam , Stadler Marc , Golparian Daniel , Unemo Magnus , Read Timothy D. , Shafer William M.
Published: September 2022

The high global incidence of gonorrhea, the lack of a protective vaccine, and the emergence of
N. gonorrhoeae
strains expressing resistance to currently used antibiotics demand that new treatment options be developed. Accordingly, we investigated whether corallopyronin A, an antibiotic which is effective against other pathogens, including
C. trachomatis
, which together with gonococci frequently cause co-infections in humans, could exert anti-gonococcal action
in vitro
and
ex vivo
, and potential resistance emergence.
Herpes Simplex Virus 1 Glycoproteins Differentially Regulate the Activity of Costimulatory Molecules and T Cells
Authors: Matundan Harry H. , Jaggi Ujjaldeep , Ghiasi Homayon
Published: September 2022

Currently no effective vaccine is available against herpes simplex virus (HSV) infection. Thus, there is a critical need to develop a safe and effective vaccine to prevent and control HSV infection. The development of such approaches will require an advanced understanding of viral genes. This study provides new evidence supporting an approach to maximize vaccine efficacy by using a combination of HSV genes to control HSV infection.
Limited Transmission of Klebsiella pneumoniae among Humans, Animals, and the Environment in a Caribbean Island, Guadeloupe (French West Indies)
Authors: Dereeper Alexis , Gruel Gaëlle , Pot Matthieu , Couvin David , Barbier Elodie , Bastian Sylvaine , Bambou Jean-Christophe , Gelu-Simeon Moana , Ferdinand Séverine , Guyomard-Rabenirina Stéphanie , Passet Virginie , Martino Frederic , Piveteau Pascal , Reynaud Yann , Rodrigues Carla , Roger Pierre-Marie , Roy Xavier , Talarmin Antoine , Tressieres Benoit , Valette Marc , Brisse Sylvain , Breurec Sébastien
Published: September 2022

In this study, we characterized the presence and genomic features of isolates of the
Klebsiella pneumoniae
species complex (KpSC) from human and nonhuman sources in Guadeloupe (French West Indies) in order to identify the reservoirs and routes of transmission. This is the first study in an island environment, an ideal setting that limits the contribution of external imports.
Impact of Automated Blood Culture Systems on the Management of Bloodstream Infections: Results from a Crossover Diagnostic Clinical Trial
Authors: Halperin Ana Verónica , del Castillo Polo Juan Antonio , Cortes-Cuevas José Luis , Cardenas Isasi María José , Ampuero Morisaki Mario , Birch Robert , Sánchez Díaz Ana María , Cantón Rafael
Published: September 2022

Bloodstream infections are associated with high rates of morbidity and mortality. Blood culture remains the gold standard for the diagnosis of BSIs.
Pf
SRPK1 Regulates Asexual Blood Stage Schizogony and Is Essential for Male Gamete Formation
Authors: Kumar Sudhir , Baranwal Vinay K. , Leeb Amanda S. , Haile Meseret T. , Oualim Kenza M. Z. , Hertoghs Nina , Vaughan Ashley M. , Kappe Stefan H. I.
Published: September 2022

Plasmodium
sexual stages represent a critical bottleneck in the parasite life cycle. Gametocytes taken up in an infectious blood meal by female anopheline mosquito get activated to form gametes and fuse to form short-lived zygotes, which transform into ookinetes to infect mosquitoes.
Validated Preclinical Mouse Model for Therapeutic Testing against Multidrug-Resistant Pseudomonas aeruginosa Strains
Authors: Warawa Jonathan M. , Duan Xiaoxian , Anderson Charles D. , Sotsky Julie B. , Cramer Daniel E. , Pfeffer Tia L. , Guo Haixun , Adcock Scott , Lepak Alexander J. , Andes David R. , Slone Stacey A. , Stromberg Arnold J. , Gabbard Jon D. , Severson William E. , Lawrenz Matthew B.
Published: September 2022

The prevalence of antibiotic resistance among bacterial pathogens is a growing problem that necessitates the development of new antibiotics. Preclinical animal models are important tools to facilitate and speed the development of novel antimicrobials.
A Neutron Diffraction Study of the Effect Produced by the Direction of Crystal Growth on the Distribution of Residual Stresses in Austenite Steel Prisms Manufactured by Selective Laser Melting
Authors: Karpov I. D. , Em V. T. , Rylov S. A. , Sul’yanova E. A. , Sukhov D. I. , Khodyrev N. A.
Published: September 2022

The effect affected by the choice of the direction of the crystal growth by selective laser melting on the distribution of residual stresses was studied on the example of initiated growing of a 20 × 20 × 70-mm prism of steel 316L. Prisms with different growth directions (along their long and short edges) have been investigated. Neutron stress diffractometry providing the measurement of all three stress tensor components in massive materials and products by a nondestructive method was used. Compressive stresses are formed in the central part of a prism in both cases. They are close to zero or transit to tensile stresses when approaching the surface. In the prism grown vertically along the long edge, tensile stresses are higher and occupy a larger volume as compared to the prism grown along the short edge. Maximum tensile stresses (~500 MPa) near the vertical prism edges are close to the ultimate yield strength of the material (~540 MPa). The maximum compressive stresses (~–400 MPa) are formed in the central part of the vertical prism.
A Model of the Electronic Structure of a FeRh Alloy Undergoing an Antferromagnetic–Ferromagnetic Phase Transition
Authors: Kurkin M. I. , Telegin A. V. , Agzamova P. A. , Bessonov V. D. , Neznakhin D. S. , Baranov N. V.
Published: September 2022

A new approach to describing the magnetic properties of FeRh alloys is proposed. It is based on two assumptions about the properties of 3d and 4d electrons in these alloys. The first is the assumption that the 4d band is submerged under the Fermi level to a depth that ensures its complete filling at a temperature T = 0 K. The second is the assumption that there are two different spatial distributions of 3d and 4d electrons that are compatible with one atomic structure. The first assumption makes it possible to explain the absence of uncompensated spins of 4d electrons in the low-temperature antiferromagnetic (AFM) phase of FeRh. The second assumption is proposed to explain the strong changes in the spin structure of the FeRh alloy upon the AFM–FM transition, while its atomic structure is almost unchanged. Attempts have been made to predict the new properties of the FeRh alloy that follow from these assumptions. Our second assumption proved to be successful and enabled us to predict the existence of local magnetic moments of 3d electrons in the AFM phase, which are larger than the magnetic moments of Fe ions. Measurements of the magnetic susceptibility of the FeRh alloy in the AFM phase confirmed this prediction.
Phase Formation Specifics in the High-Alumina Region of the СаО–Al2О3 System
Authors: Trubitsyn M. A. , Furda L. V. , Yapryntsev M. N. , Volovicheva N. A.
Published: September 2022

Phase formation of calcium monoaluminate and calcium dialuminate in the СаО–Al2О3 system in the range 230–1450°C was studied using a model powder mixture comprising aluminum and calcium hydroxides. The onset of formation of an intermediate phase Ca12Al14O33 (С12А7) was observed at 430°С. At 1100°С, the appearance of CaAl4O7 (CA2) and the presence of κ-Al2O3 were observed. The onset of intense formation of the CaAl2O4 (СА) phase is at 1170°С. In the range 1250–1400°С, the CA amount increases notably, while the СА2 proportion remains almost unchanged. The final formation of the CA and CA2 target phases occurs in 2 h at 1450°С. The syntheses of CA and CA2 is controlled by Ca2+ diffusion inward the aluminum-enriched cores of spherulites. Energy dispersive X-ray spectroscopy elucidated the CA and CA2 distribution in the form of concentric layers.
The Role of a Detachment Fault in the Spatial Distribution of Ore-Bearing Paleofluid Flows in the Central Kolyma Region: A Nonconventional Approach to Predictive Metallogenic Modeling
Authors: Savchuk Yu. S. , Volkov A. V.
Published: September 2022

Abstract—

The Central Kolyma region is the main gold-bearing part of the Verkhoyansk–Kolyma fold-and-thrust belt. Analysis of the developed geodynamic models of fold and thrust belt formation mechanisms, the Verkhoyansk–Kolyma belt in particular, suggests the leading role of subhorizontal movements on the detachment zone (decollement) at the base of an orogen as the “sole,” on which nappes detached at an early stage and with which major reverse strike-slip listric faults were directly associated at the collisional stage. In our opinion, the role of a detachment fault, the most important regional structure, is obviously underestimated in predictive metallogenic models. The detachment fault zone is complicated by transverse NE-trending faults, where its thickness and the fluid permeability can occur. The paper proposes a variant that links previously discovered gold deposits and occurrences in five gold mineralization strips along the inferred paleofluid flow routes. Here, the paleofluid flow route is the horizontal projection of the most probable migration pathway of released fluids from their generation zone to the ore deposition zone, which is drawn across the largest ore accumulations.
Eligibility for faricimab in a real-world neovascular age-related macular degeneration population: a cross-sectional study
Authors: Jern Iréne , Forsell Sara , Norberg Helena
Published: September 2022

Objectives

To investigate the eligibility of a real-world neovascular age-related macular degeneration (nAMD) population for the TENAYA and LUCERNE trials (testing faricimab), and to compare the eligible real-world patients to trial participants.

Design, settings and participants

In this retrospective cross-sectional study, we used data from the Swedish Macula Registry (SMR) between 1 January 2017 and 31 December 2020. Persons were eligible if they fulfilled the main inclusion criteria in TENAYA and LUCERNE: (1) nAMD diagnosis, (2) treatment naïve, (3) ≥50 years and (4) best-corrected visual acuity (BCVA) of 78–24 letters.

Main outcome measures

Characteristics at the original visit of the eligible SMR population and baseline data from the clinical trials were compared.

Results

In total, 27 962 individuals with nAMD were registered in SMR. A total of 15 399 (55%) individuals were treatment naïve; of these, 15 368 (55%) were ≥50 years and 13 265 (47%) also had BCVA of 78–24 letters and fulfilled eligibility. Among treatment-naïve individuals, 86% were eligible and the BCVA criterion was the most common reason for non-eligibility. The eligible SMR population was significantly older than either TENAYA or LUCERNE. SMR included more women and patients with worse visual acuity than TENAYA, while SMR patients were diagnosed more quickly than LUCERNE.

Conclusions

Almost half of the real-world nAMD population in SMR fulfilled the main inclusion criteria of the TENAYA and LUCERNE trials. Among treatment-naïve individuals, 86% were eligible. Marginally differences were shown between the eligible SMR population and the trial populations. The SMR population were older and more similar to the population in LUCERNE than TENAYA.
BND-22, a first-in-class humanized ILT2-blocking antibody, promotes antitumor immunity and tumor regression
Authors: Mandel Ilana , Haves Ziv Dana , Goldshtein Ilana , Peretz Tsuri , Alishekevitz Dror , Fridman Dror Anna , Hakim Motti , Hashmueli Sharon , Friedman Itay , Sapir Yair , Greco Rita , Qu Hongjing , Nestle Frank , Wiederschain Dmitri , Pao Lily , Sharma Sharad , Ben Moshe Tehila
Published: September 2022

Background

Cancer immunotherapy has revolutionized cancer treatment. However, considering the limited success of immunotherapy to only some cancer types and patient cohorts, there is an unmet need for developing new treatments that will result in higher response rates in patients with cancer. Immunoglobulin-like transcript 2 (ILT2), a LILRB family member, is an inhibitory receptor expressed on a variety of immune cells including T cells, natural killer (NK) cells and different myeloid cells. In the tumor microenvironment, binding of class I MHC (in particular HLA-G) to ILT2 on immune cells mediates a strong inhibitory effect, which manifests in inhibition of antitumor cytotoxicity of T and NK cells, and prevention of phagocytosis of the tumor cells by macrophages.

Methods

We describe here the development and characteristics of BND-22, a novel, humanized monoclonal antibody that selectively binds to ILT2 and blocks its interaction with classical MHC I and HLA-G. BND-22 was evaluated for its binding and blocking characteristics as well as its ability to increase the antitumor activity of macrophages, T cells and NK cells in various in vitro, ex vivo and in vivo systems.

Results

Collectively, our data suggest that BND-22 enhances activity of both innate and adaptive immune cells, thus generating robust and comprehensive antitumor immunity. In humanized mice models, blocking ILT2 with BND-22 decreased the growth of human tumors, hindered metastatic spread to the lungs, and prolonged survival of the tumor-bearing mice. In addition, BND-22 improved the antitumor immune response of approved therapies such as anti-PD-1 or anti-EGFR antibodies.

Conclusions

BND-22 is a first-in-human ILT2 blocking antibody which has demonstrated efficient antitumor activity in various preclinical models as well as a favorable safety profile. Clinical evaluation of BND-22 as a monotherapy or in combination with other therapeutics is under way in patients with cancer.

Trial registration number

NCT04717375.
Unveiling the tumor immune microenvironment of organ-specific melanoma metastatic sites
Authors: Conway Jordan W , Rawson Robert V , Lo Serigne , Ahmed Tasnia , Vergara Ismael A , Gide Tuba N , Attrill Grace Heloise , Carlino Matteo S , Saw Robyn P M , Thompson John F , Spillane Andrew J , Shannon Kerwin F , Shivalingam Brindha , Menzies Alexander Maxwell , Wilmott James S , Long Georgina V , Scolyer Richard A , Pires da Silva Ines
Published: September 2022

Background

The liver is a known site of resistance to immunotherapy and the presence of liver metastases is associated with shorter progression-free and overall survival (OS) in melanoma, while lung metastases have been associated with a more favorable outcome. There are limited data available regarding the immune microenvironment at different anatomical sites of melanoma metastases. This study sought to characterize and compare the tumor immune microenvironment of liver, brain, lung, subcutaneous (subcut) as well as lymph node (LN) melanoma metastases.

Methods

We analyzed OS in 1924 systemic treatment-naïve patients with AJCC (American Joint Committee on Cancer) stage IV melanoma with a solitary site of organ metastasis. In an independent cohort we analyzed and compared immune cell densities, subpopulations and spatial distribution in tissue from liver, lung, brain, LN or subcut sites from 130 patients with stage IV melanoma.

Results

Patients with only liver, brain or bone metastases had shorter OS compared to those with lung, LN or subcutaneous and soft tissue metastases. Liver and brain metastases had significantly lower T-cell infiltration than lung (p=0.0116 and p=0.0252, respectively) and LN metastases (p=0.0116 and p=0.0252, respectively). T cells were further away from melanoma cells in liver than lung metastases (p=0.0335). Liver metastases displayed unique T-cell profiles, with a significantly lower proportion of programmed cell death protein-1+ T cells compared to all other anatomical sites (p<0.05), and a higher proportion of TIM-3+ T cells compared to LN (p=0.0004), subcut (p=0.0082) and brain (p=0.0128) metastases. Brain metastases had a lower macrophage density than subcut (p=0.0105), liver (p=0.0095) and lung (p<0.0001) metastases. Lung metastases had the highest proportion of programmed death ligand-1+ macrophages of the total macrophage population, significantly higher than brain (p<0.0001) and liver metastases (p=0.0392).

Conclusions

Liver and brain melanoma metastases have a significantly reduced immune infiltrate than lung, subcut and LN metastases, which may account for poorer prognosis and reduced immunotherapy response rates in patients with liver or brain metastases. Increased TIM-3 expression in liver metastases suggests TIM-3 inhibitor therapy as a potential therapeutic opportunity to improve patient outcomes.
Automated, scaled, transposon-based production of CAR T cells
Authors: Lock Dominik , Monjezi Razieh , Brandes Caroline , Bates Stephan , Lennartz Simon , Teppert Karin , Gehrke Leon , Karasakalidou-Seidt Rafailla , Lukic Teodora , Schmeer Marco , Schleef Martin , Werchau Niels , Eyrich Matthias , Assenmacher Mario , Kaiser Andrew , Prommersberger Sabrina , Schaser Thomas , Hudecek Michael
Published: September 2022

Background

There is an increasing demand for chimeric antigen receptor (CAR) T cell products from patients and care givers. Here, we established an automated manufacturing process for CAR T cells on the CliniMACS Prodigy platform that is scaled to provide therapeutic doses and achieves gene-transfer with virus-free Sleeping Beauty (SB) transposition.

Methods

We used an advanced CliniMACS Prodigy that is connected to an electroporator unit and performed a series of small-scale development and large-scale confirmation runs with primary human T cells. Transposition was accomplished with minicircle (MC) DNA-encoded SB100X transposase and pT2 transposon encoding a CD19 CAR.

Results

We defined a bi-pulse electroporation shock with bi-directional and unidirectional electric field, respectively, that permitted efficient MC insertion and maintained a high frequency of viable T cells. In three large scale runs, 2E8 T cells were enriched from leukapheresis product, activated, gene-engineered and expanded to yield up to 3.5E9 total T cells/1.4E9 CAR-modified T cells within 12 days (CAR-modified T cells: 28.8%±12.3%). The resulting cell product contained highly pure T cells (97.3±1.6%) with balanced CD4/CD8 ratio and a high frequency of T cells with central memory phenotype (87.5%±10.4%). The transposon copy number was 7.0, 9.4 and 6.8 in runs #1–3, respectively, and gene analyses showed a balanced expression of activation/exhaustion markers. The CD19 CAR T cell product conferred potent anti-lymphoma reactivity in pre-clinical models. Notably, the operator hands-on-time was substantially reduced compared with conventional non-automated CAR T cell manufacturing campaigns.

Conclusions

We report on the first automated transposon-based manufacturing process for CAR T cells that is ready for formal validation and use in clinical manufacturing campaigns. This process and platform have the potential to facilitate access of patients to CAR T cell therapy and to accelerate scaled, multiplexed manufacturing both in the academic and industry setting.
Anti-RA33 antibodies are present in a subset of patients with immune checkpoint inhibitor-induced inflammatory arthritis
Authors: Cappelli Laura C , Bingham Clifton O , Forde Patrick M , Anagnostou Valsamo , Brahmer Julie , Lipson Evan J , Mammen Jennifer , Schollenberger Megan , Shah Ami A , Darrah Erika
Published: September 2022

Objective

Patients with inflammatory arthritis (IA) associated with immune checkpoint inhibitor (ICI) treatment for cancer are typically seronegative for anti-cyclic citrullinated peptide (CCP) antibodies and rheumatoid factor, but little is known about the presence of other autoantibodies in this patient population. We investigated the prevalence and characteristics of anti-RA33 antibodies in patients with ICI-induced IA.

Methods

Anti-RA33 ELISAs were performed on sera from four groups of patients: 79 with ICI-induced IA, 52 with rheumatoid arthritis (RA), 35 treated with ICIs without IA during follow-up and 50 healthy controls. Anti-RA33 positivity and level, clinical and demographic data were compared across groups.

Results

Anti-RA33 antibodies were found in 9/79 (11.4%) patients with ICI-induced IA but in 0/35 patients treated with ICIs who did not develop IA (0%; p=0.04). Of the patients positive for anti-RA33, two had sera available from before ICI treatment; anti-RA33 antibodies were present in both pre-ICI treatments. In patients with RA, 7.7% were positive for anti-RA33 antibodies as were 2% of healthy controls. In ICI-induced IA, anti-RA33 antibodies were associated with anti-CCP antibodies (p=0.001). We found no statistically significant differences in other clinical characteristics in those with and without anti-RA33 antibodies.

Conclusions

Anti-RA33 antibodies are present in a subset of patients with ICI-induced IA, absent in other ICI-treated patients and may be a biomarker for developing IA. Additional studies evaluating serial samples before and after ICI treatment will further establish the temporal relationship of these antibodies to IA development.
Reactive arthritis after SARS-CoV-2 infection
Authors: Dombret Sophia , Skapenko Alla , Schulze-Koops Hendrik
Published: September 2022

SARS-CoV-2 has been recognised as a potential trigger of inflammatory arthritis in individuals with inflammatory rheumatic diseases as well as in previously unaffected individuals. However, new-onset arthritis after COVID-19 is a heterogeneous phenomenon that complicates differential diagnosis. For example, acute arthritis with features of viral arthritis has been reported after COVID-19, as has crystal-induced arthritis. Arthritides mimicking reactive arthritis (ReA) have also been described, but these patients often do not fulfil the typical features of ReA: several reports describe cases of patients older than 45 years at the onset of arthritis, and the characteristic genetic feature of ReA, HLA-B27, is rarely found. Because viral infections are much less likely to cause ReA than bacterial infections, and respiratory infections are rarely the cause of ReA, it is currently unknown whether SARS-CoV-2 can cause true ReA. Here, we report the case of a 30-year-old patient who presented with acute pain, swelling and redness in the left metatarsophalangeal (MTP) joint and ankle 7 days after resolution of a SARS-CoV-2 infection. Diagnostics revealed arthritis of the MTP2, synovitis of the upper ankle with significant joint effusion and peritendinitis of the flexor tendons. Based on the clinical manifestations and diagnostic test results, ReA appeared to be the most likely cause. A screening for typical ReA-associated infections was negative. The patient was treated with NSAIDs and intra-articular and systemic glucocorticoids. At a follow-up visit after discontinuation of glucocorticoids, the patient was symptom-free. Overall, we observed a ReA with typical clinical, genetic and patient characteristics after SARS-CoV-2 infection, and we conclude that a direct association with COVID-19 is highly plausible.
Data-rich but model-resistant: an evaluation of data-limited methods to manage fisheries with failed age-based stock assessments
Authors: Legault Christopher M. , Wiedenmann John , Deroba Jonathan J. , Fay Gavin , Miller Timothy J. , Brooks Elizabeth N. , Bell Richard J. , Langan Joseph A. , Cournane Jamie M. , Jones Andrew W. , Muffley Brandon
Published: September 2022

Age-based stock assessments are sometimes rejected by review panels due to large retrospective patterns. When this occurs, data-limited approaches are often used to set catch advice, under the assumption that these simpler methods will not be impacted by the problems causing retrospective patterns in the age-based assessment. This assumption has never been formally evaluated. Closed-loop simulations were conducted where a known source of error caused a retrospective pattern in an age-based assessment. Twelve data-limited methods, an ensemble of a subset of these methods, and a statistical catch-at-age model with retrospective adjustment were all evaluated to examine their ability to prevent overfishing and rebuild overfished stocks. Overall, none of the methods evaluated performed best across the scenarios. A number of methods performed consistently poorly, resulting in frequent and intense overfishing and low stock sizes. The retrospective adjusted statistical catch-at-age assessment performed better than a number of the alternatives explored. Thus, using a data-limited approach to set catch advice will not necessarily result in better performance than relying on the age-based assessment with a retrospective adjustment.
Swampland criteria for f(R) gravity derived with a Gaussian process
Authors: Elizalde Emilio , Khurshudyan Martiros
Published: September 2022

A Gaussian Process (GP) is used to derive Swampland criteria for f(R) modifications of General Relativity (GR). The fact that observational data are directly taken into account allows obtaining clean upper and lower limits for the Swampland criteria, in an unbiased, natural way. They correspond to a dark-energy dominated Universe, having assumed the form of the f(R) gravity, only. To perform this study, 40-point H(z) data are used, consisting of 30-point samples deduced from the differential age method, and 10-point additional samples coming from the radial BAO method. The constraints obtained for each f(R) model parameter choice indicate whether it is possible to alleviate the $$H_{0}$$

H
0

tension problem efficiently due to the used $$H_{0}$$

H
0

values reported by the Planck and Hubble missions. The elaborated structure of the analysis forced to limit the number of specific models, but the methodology here discussed is applicable to study any form of f(R) gravity.
Algorithm Design for Asset Trading Under Multiple Factors
Authors: Xu Li-Jun , Wei Shou-Yu , Lu Xiao-Qing , He Ze-Hua , Zhu Jia-Ming
Published: September 2022

For the strategy of investing in gold and Bitcoin, first collect the historical prices of two types of investment products in the market, and use the wavelet neural network model and WT-LSTM model to model and analyze to predict the future price trends of gold and Bitcoin. Second, considering the difference in price fluctuations between gold and Bitcoin, based on the GARCH-EVT model to increase the risk uncertainty of financial assets, proposes how to achieve the best trading strategy under risk characteristics. Finally, considering the influence of transaction rate on income, we use particle swarm algorithm and genetic algorithm to study what kind of transaction rate can achieve maximum income. The study found that although traders can predict future trends based on daily price changes, due to the different risk factors of gold and Bitcoin, and the different sensitivity of the two financial assets to transaction costs, trading strategies will be very different.
The Component Hierarchy of Chain-Free Cooperating Distributed Regular Tree Grammars Revisited
Authors: Gazdag Zsolt , Vágvölgyi Sándor
Published: September 2022

We denote by [Formula: see text] the class of tree languages generated by chain-free distributed regular tree grammars of [Formula: see text] components cooperating with terminal strategy. Dányi and Fülöp [2] showed that the hierarchy [Formula: see text], [Formula: see text] contains an infinite proper hierarchy. We improve their result showing that for each [Formula: see text], [Formula: see text].
A Comparative Study on CORDIC Algorithms and Applications
Authors: Changela Ankur , Zaveri Mazad , Verma Deepak
Published: September 2022

Jack Edward Volder had introduced the CORDIC (COordinate Rotation DIgital Computer) in 1959. This year, critical development and advancement of the CORDIC algorithm have reached 62 years. The VLSI implementation of the CORDIC requires simple hardware (of the form add–shift), which makes CORDIC the most suitable building block for many real-time applications. The sequential nature of the CORDIC computation and scale factor are crucial aspects to be considered as they limit the overall performance of the algorithm. In this work, we have studied the various CORDIC algorithms and their architectures which improve the performance of the standard radix-2 CORDIC algorithm. This comparative study aims to provide first-order information on CORDIC algorithm implementations, including their potential applications. In addition, the study also reflected the works done by numerous researchers and highlighted the limitations of the existing architectures and algorithms, and executed the assessment using various parameters such as convergence range, number of iterations required to achieve the complete rotation, and hardware resource complexity to implement [Formula: see text]/[Formula: see text] rotator, [Formula: see text] rotator, and scale factor compensation. We have also carried out error analysis of various CORDIC algorithms in terms of root-mean-squared error (RMSE) and peak signal-to-noise ratio (PSNR). The number of iterations, scale factor, and the sequential computing of the micro-rotations can be identified as significant improvement areas of the CORDIC algorithm and modifications are required for real-time applications.
DYNAMICS OF LEPTOSPIROSIS DISEASE IN CONTEXT OF PIECEWISE CLASSICAL-GLOBAL AND CLASSICAL-FRACTIONAL OPERATORS
Authors: QU HAIDONG , SAIFULLAH SAYED , KHAN JAVED , KHAN ARSHAD , UR RAHMAN MATI , ZHENG GENGZHONG
Published: September 2022

In this paper, we use newly introduced piecewise classical-global and classical-fractional operators to study the dynamics of the Leptospirosis disease model. The existence and uniqueness of the solution to piecewise derivatives are examined for the suggested problem. The piecewise iterative Newton polynomial method is used to obtain an approximate solution to the suggested problem. In addition, a numerical scheme for the piecewise Leptospirosis model with integer and fractional orders is established. The numerical simulation of the piecewise derivable problem under consideration is presented in classical as well as various fractional orders.
USING THE MEASURE OF NONCOMPACTNESS TO STUDY A NONLINEAR IMPULSIVE CAUCHY PROBLEM WITH TWO DIFFERENT KINDS OF DELAY
Authors: SHAH KAMAL , MLAIKI NABIL , ABDELJAWAD THABET , ALI ARSHAD
Published: September 2022

We apply the noncompactness measure by Mawhin to establish sufficient conditions for the existence and uniqueness (EU) of solution to a nonlinear Cauchy problem. The aforesaid problem is investigated under impulsive and nonlinear integral boundary conditions. Further, the problem under consideration contains Caputo-type fractional-order derivative while two different kinds of delay are also involved. After establishing the existence results, we derive some adequate results for the stability analysis of Hyers–Ulam (HU) type. Here, it should be kept in mind that the proposed tools can reduce the strong compact condition by weaker compactness. For justification, we provide some examples also.
EFFECT OF TREATMENT AND PROTECTION MEASURES ON THE OUTBREAK OF INFECTIOUS DISEASE USING AN SIR EPIDEMIC MODEL WITH TWO DELAYS, DISCRETE AND DISTRIBUTED
Authors: MENOUER MOHAMMED AMINE , GUL NADIA , DJILALI SALIH , ZEB ANWAR , KHAN ZAREEN A.
Published: September 2022

In this paper, we aim to analyze the effect of treatment and protection measures on the spread of infectious disease. Therefore, we formulate a delayed mathematical which contains a discrete delay which stands for the duration of protection and distributed delay that represents the repulsed individuals from treatment. The main result is to show that the model has threshold behavior governed by [Formula: see text]. For [Formula: see text], it is shown that the disease-free equilibrium is globally stable. However, for [Formula: see text], it is proved that the semiflow is uniformly persistent, and the endemic equilibrium is globally stable. Another purpose is fixed in this paper, which consists of studying the effect of treatment and protection measures on the spread of the disease, and to distinguish the minimal protection and treatment measure for reducing the basic reproduction number below one. The results are supported numerically using numerical simulations.
On the endomorphisms and derivations of some Leibniz algebras
Authors: Kurdachenko Leonid A. , Subbotin Igor Ya. , Yashchuk Viktoriia S.
Published: September 2022

We study the endomorphisms and derivations of an infinite-dimensional cyclic Leibniz algebra. Among others it was found that if [Formula: see text] is a cyclic infinite-dimensional Leibniz algebra over a field [Formula: see text], then the group of all automorphisms of [Formula: see text] is isomorphic to a multiplicative group of the field [Formula: see text]. The description of an algebra of derivations of a cyclic infinite-dimensional Leibniz algebra has been obtained.
Freiman Borel-type ideals
Authors: Zhu Guangjun , Zhao Yakun , Duan Shiya , Yang Yulong
Published: September 2022

An equigenerated monomial ideal [Formula: see text] in the polynomial ring [Formula: see text] is a Freiman ideal if [Formula: see text], where [Formula: see text] is the analytic spread of [Formula: see text] and [Formula: see text] is the least number of monomial generators of [Formula: see text]. In this paper, we classify certain classes of Borel-type ideals, including Borel ideals with multiple Borel generators and principal [Formula: see text]-Borel ideals, which are Freiman.
EFFECT OF ADJUSTABLE REVERSE TRACTION FRAMES IN THE PREOPERATIVE TREATMENT OF TYPE C PILON FRACTURES OF THE DISTAL TIBIA
Authors: ZHANG YUN , JIANG XING-DUO , CHEN TIAN , CHENG LUN , LUO JIAN , CHANG JIHUI , QIU XUZHONG , LI KAI , TANG DONGMEI , GUO DEHONG , DAI LING , ZHANG SHUANG
Published: September 2022

There is no unified standard for the early treatment of Type C pilon fractures. At present, the calcaneal traction technique and adjustable reverse traction frame are commonly used. In order to analyze the clinical effects of these two techniques more accurately, the effect of the adjustable reverse traction frame in early treatment of Type C pilon fractures was compared. The Orthopedics Department of People’s Hospital of Zhongjiang County collected the clinical data of 57 cases of Type C pilon fracture of the distal tibia in the preoperative period from January 2018 to December 2021. There were 28 cases treated with calcaneal traction and 29 cases with adjustable reverse external frame. The results show that the use of the adjustable reverse traction frame in the treatment of Type C pilon fracture has the dual advantages of calcaneal traction and the traditional external frame. These include simple operation and assembly, low cost, and the ability to relieve swelling of the affected limb soon after application, which shortens the preoperative waiting period, reduces pain in the affected limb after injury, shortens the hospital stay, effectively reduces the fractured and staggered parts of the fracture, and obtains good remediation efficacy.
THE INFLUENCE OF HEIGHT ON TEST-RETEST RELIABILITY OF POSTURAL BALANCE MEASURES IN HEALTHY YOUNG ADULTS
Authors: EOM GWANG-MOON , KWON YU-RI , KIM DONG-YEON , KO JUNGHYUK , KIM JI-WON
Published: September 2022

Height is associated with postural balance performance. However, there has been no study on whether the test-retest reliability of the balance performance variables is related to height. The goal of our study was to analyze the effect of body height on the test-retest reliability of center of pressure (COP) variables during natural and feet-together stances in healthy young subjects. Twenty normal young men were classified into the short height group (height range, 163–174[Formula: see text]cm) and the tall height group (height range, 176–184[Formula: see text]cm) with 10 subjects each to investigate the influence of height on test-retest reliability. All subjects performed the static balance test on a commercial force plate in feet-together and natural stance conditions three times. Four variables were calculated from the COP data. COP distance, COP area, COP velocity, and COP mean frequency were selected as the postural balance variables. Intraclass correlation coefficient (ICC) was evaluated for an analysis of the test-retest reliability of each COP variable. In both stance conditions, the COP distance and the COP area in the short height group (ICC = 0.717–0.902) showed better test-retest reliability compared to those in the tall height group (ICC = 0.146–0.688). COP velocity had the highest ICC value in both stance conditions (ICC = 0.744–0.970). Additionally, the short height group showed slightly better reliability in the feet-together stance condition, whereas the tall height group showed slightly higher ICC value in the natural stance condition. These results suggest that height should be considered for a more reliable assessment of repetitive static balance performance. Our findings might be useful for the development of an optimal static balance test protocol regardless of the effect of height.
OVERSAMPLING TECHNIQUE-BASED DATA AUGMENTATION AND 1D-CNN AND BIDIRECTIONAL GRU ENSEMBLE MODEL FOR HUMAN ACTIVITY RECOGNITION
Authors: KIM YEON WOOK , CHO WOO HYEONG , KIM KYU SUNG , LEE SANGMIN
Published: September 2022

The success of the human activity recognition (HAR) algorithm of a wearable inertial sensor depends on the extraction of good temporal dynamics from the sequential motor movement of humans. In the past, a heuristic method was used for the feature extraction process. Recently, deep neural network (DNN)-based studies, in which this process is automatically performed in the model, have shown good results. The performance of the DNN models is good and almost all processes are automated; however, they have some limitations—data-imbalance problems in the dataset and the small data decrease the performance. In this study, the HAR public dataset was improved by introducing an oversampling technique-based data-augmentation algorithm, and a stacking ensemble model with a one-dimensional convolutional neural network and a bidirectional gated recurrent unit as the head was used for classification. The HAR public dataset used Wireless sensor data mining (WISDM) and the University of California, Irvine human activity recognition using smartphones data set (UCI-HAR). Consequently, the proposed model showed better performance than that of previous studies for both datasets. The accuracy of the proposed model was 99.49% and 99.48%; the F1-score of the model was 99.84% and 99.78%, respectively.
COMPUTER-AIDED EARLY DIAGNOSIS OF ALZHEIMER’S DISEASE BASED ON COST-SENSITIVE AND DEEP RESIDUAL CONVOLUTIONAL NEURAL NETWORK
Authors: SUN HAIJING , CAO YONG , SHAO YICHUAN
Published: September 2022

Alzheimer’s disease (AD) is a neurodegenerative illness of unclear pathogenic origin that is characterized in its early stages by a steady deterioration in memory and cognitive impairment. Mild cognitive impairment (MCI) is a preclinical stage of AD. If a patient is diagnosed with early MCI, he or she can take preventive actions before permanent brain damage occurs. Improper diagnosis of MCI may cause the patient to miss the best time for treatment and incur heavy cost. Cost-sensitivity refers to the significant difference in cost to the patient between a misdiagnosis of MCI as normal control (NC) or AD and a misdiagnosis of NC or AD as MCI. In order to give consideration to both accuracy and cost, a computer-aided diagnosis algorithm based on cost-sensitive, attention mechanism and deep residual convolutional neural network (CSAResnet) was proposed for AD early diagnosis from MRI images. MRI data were obtained from the open-access AD Neuroimaging Initiative (ADNI) database. The experimental results show that the CSAResnet algorithm can balance the reduction of the total misclassification cost and the improvement of the accuracy to distinguish AD and MCI patients from NC subjects. It can address multiple classes of cost-sensitive problems.
CLINICAL EFFECT OF ENDOSCOPIC TITANIUM CLIPS COMBINED WITH TISSUE ADHESIVE IN THE TREATMENT OF GOV2 GASTRIC FUNDAL VARICES
Authors: TANG BIN , LI YUE PING , JIANG BO , ZHANG SHUANG
Published: September 2022

Objective: To analyze the effect of endoscopic titanium clips combined with tissue adhesive in treating GOV2 (Type 2 Gastroesophageal Varices) patients. Methods: One-hundred-and-seventeen GOV2 patients from June 2018 to June 2020 were divided into the observation group ([Formula: see text]) and control group ([Formula: see text]). The observation group was treated with endoscopic titanium clip combined with the tissue adhesive, while controls were treated with tissue adhesive alone. The clinical effects were compared at 1, 6, and 24 months. Results: Overall response rates of the observation group at 1, 6, and 24 months were 98.31%, 96.61%, and 91.53%, respectively, vs. 81.03%, 76.27%, and 55.17% in controls ([Formula: see text]). The number, diameters, red color sign proportion of varicose veins, and incidence of bleeding in the observation group were lower than the control group, and the GQOL-74 (Generic Quality of Life Inventory 74) score was higher at 1, 6, and 24 months ([Formula: see text]). There was no significant difference in complications, mortality at 6 and 24 months, and recurrence rate at 6 months ([Formula: see text]); however, the recurrence rate at 24 months after treatment was lower in the observation group (6.78% vs. 20.69%) ([Formula: see text]). Conclusions: Endoscopic titanium clips combined with tissue adhesive can be applied to treat GOV2 patients.
EVALUATION OF THE STEREOSCOPIC DOSE DISTRIBUTION IN ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY ROOM USING N1 PHANTOM AND TLD TECHNIQUE
Authors: ZHUANG ZHI-LIN , WU CHANG-YU , LIN CHENG-HSUN
Published: September 2022

This study envisaged the evaluation of the stereoscopic dose distribution and the corresponding exposure dose for the medical staff in endoscopic retrograde cholangiopancreatography (ERCP) room using the spatial dose distribution method and thermo-luminescent dosimetry (TLD) technique. Feasibility screening and calibration of 135 new TLD-100H chips were performed and sealed into 45 packages with 3 TLDs per pack. Subsequently, the 45 TLD packs were allocated in a matrix form in the ERCP room ([Formula: see text][Formula: see text]cm2) with various heights of 85, 90, 130, 150, and 180[Formula: see text]cm above the ground. In addition, three human-sized dolls with lead vast were located at the position of the medical staff to simulate the ambient exposure dose. The TLDs were held for 2-minute exposure (max, min, average) [Formula: see text] Gy dose as 85[Formula: see text]cm (520.9, 14.9, 31.1), 90[Formula: see text]cm (428.6, 15.7, 28.6), 130[Formula: see text]cm (40.7, NA, 28.0), 150[Formula: see text]cm (1650.3, NA, 1650.3) and 180[Formula: see text]cm (17.6, 15.0, 16.4), respectively. The minimum detectable limit (MDL) of the TLD chips was 6.85[Formula: see text]nC, and the TLD dose calibration curve was revised by using a weighting factor according to lean backward scenario to reach low interception. It was found that the maximal exposure dose of the annual workload (12[Formula: see text]m/d*5[Formula: see text]d/wk*50[Formula: see text]wk/yr=3000[Formula: see text]m) was overestimated as 14.7, 14.5, and 14.1[Formula: see text]mGy, respectively for the medical doctors, radiologists and nurses from the viewpoint of health physics.