bluuebunny/crossref_metadata_2025 huggingface dataset:
Successful Surgical Management of Dystocia in a Cat
Authors: Parmar K. H. , Vadaliya J. V. , Raval R. J. , Vala K. B. , Chikhaliya P. S.
Published: May 2017

In the polytocus small animals there may be a complete or a partial failure of the uterus to start
contracting. In partial failure the uterus may bring the first fetus to the pelvic inlet from where it
is delivered by abdominal straining. No further fetuses were present and uterine contraction ceases.
An idiopathic type of primary uterine inertia has been described, in which delivery starts normally
and several members of the litter are delivered normally. There is no evidence of obstruction to
birth through maternal or fetal cause. The uterus stops contracting and does not resume unless
ecbolic therapy is given. It could be argued that this could be classified as a partial rather than
a complete primary uterine inertia (Peter Jackson, 2004).Uterine inertia that is lack of normal
physiologic uterine contraction during or after parturition, is a common condition encountered in
bovine. However, it is comparatively less reported in canine and feline.
Proteins in Preservation Fluid as Predictors of Delayed Graft Function in Kidneys from Donors after Circulatory Death
Authors: van Balkom Bas W.M. , Gremmels Hendrik , Ooms Liselotte S.S. , Toorop Raechel J. , Dor Frank J.M.F. , de Jong Olivier G. , Michielsen Laura A. , de Borst Gert J. , de Jager Wilco , Abrahams Alferso C. , van Zuilen Arjan D. , Verhaar Marianne C.
Published: May 2017

Background and objectives

Kidney transplantation is the preferred treatment for ESRD, and donor kidney shortage urges proper donor-recipient matching. Zero-hour biopsies provide predictive values for short- and long-term transplantation outcomes, but are invasive and may not reflect the entire organ. Alternative, more representative methods to predict transplantation outcome are required. We hypothesized that proteins accumulating in preservation fluid during cold ischemic storage can serve as biomarkers to predict post-transplantation graft function.

Design, setting, participants, & measurements

Levels of 158 proteins were measured in preservation fluids from kidneys donated after circulatory death (Maastricht category III) collected in two Dutch centers (University Medical Center Utrecht and Erasmus Medical Center Rotterdam) between 2013 and 2015. Five candidate biomarkers identified in a discovery set of eight kidneys with immediate function (IF) versus eight with delayed graft function (DGF) were subsequently analyzed in a verification set of 40 additional preservation fluids to establish a prediction model.

Results

Variables tested for their contribution to a prediction model included five proteins (leptin, periostin, GM-CSF, plasminogen activator inhibitor-1, and osteopontin) and two clinical parameters (recipient body mass index [BMI] and dialysis duration) that distinguished between IF and DGF in the discovery set. Stepwise multivariable logistic regression provided a prediction model on the basis of leptin and GM-CSF. Receiver operating characteristic analysis showed an area under the curve (AUC) of 0.87, and addition of recipient BMI generated a model with an AUC of 0.89, outperforming the Kidney Donor Risk Index and the DGF risk calculator, showing AUCs of 0.55 and 0.59, respectively.

Conclusions

We demonstrate that donor kidney preservation fluid harbors biomarkers that, together with information on recipient BMI, predict short-term post-transplantation kidney function. Our approach is safe, easy, and performs better than current prediction algorithms, which are only on the basis of clinical parameters.

Podcast

This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2017_05_05_Balkom.mp3
SIMVASTATIN ATTENUATES RENAL FAILURE IN MICE WITH A 5/6 SUBTOTAL NEPHRECTOMY
Authors: Cahyawati Putu Nita , . Ngatidjan , Sari Dwi Cahyani Ratna , Romi Muhammad Mansyur , Arfian Nur , Romi Muhammad Mansyur , Romi Muhammad Mansyur , Arfian Nur , Arfian Nur
Published: May 2017

Objective: The objective of this study to investigate the effect of simvastatin on kidney fibrosis in mice with a 5/6 subtotal nephrectomy.Methods: Thirty adults (3 mo old) male Swiss mice were submitted to a 5/6 subtotal nephrectomy and studied after 14 d. Animals were divided into five groups: 5/6 subtotal nephrectomy (SN, n=6), sham operation (SH, n=6), simvastatin 5.2 mg/kg body weight (SIM-1, n=6), simvastatin 10.4 mg/kg body weight (SIM-2, n=6), and simvastatin 20.8 mg/kg body weight (SIM-3, n=6) groups. At sacrifice, kidneys were harvested for morphology (glomerulosclerosis (GS), tubular injury and interstitial fibrosis), immunostaining (α-smooth muscle actin (α-SMA)) and platelet-derived growth factor receptor beta (PDGF-Rβ) and reverse transcriptase-polymerase chain reaction (RT-PCR) (MCP-1, ICAM-1, nephrin, and podocin) analysis.Results: Glomerulosclerosis, tubular injury and interstitial fibrosis in the simvastatin group was significantly lower than SN group (p<0.05). Simvastatin significantly reduced α-SMA expression (3.61±1.06 vs 7.91±1.26, p<0.05, SIM-1 vs SN; 2.86±0.61 vs 7.91±1.26, p<0.05, SIM-2 vs SN; 1.71±0.50 vs 7.91±1.26, p<0.05, SIM-3 vs SN), MCP-1 was markedly expressed in the 5/6 subtotal nephrectomy kidneys and was reduced with simvastatin (1.4±0.64 vs 0.57±0.23, p<0.05, SN vs SIM-1; 1.4±0.64 vs 0.6±0.26, p<0.05, SN vs SIM-2; 1.4±0.64 vs 0.52±0.21, SN vs SIM-3, p<0.05). Simvastatin did not increase nephrin expression, but it increased podocin expression significantly in the SIM-3 group.Conclusion: Simvastatin significantly attenuated GS, tubular injury and interstitial fibrosis through the downregulation of myofibroblast expansion and inflammatory mediators in mice with a 5/6 subtotal nephrectomy.
INCIDENCE AND RISK FACTORS OF RENAL IMPAIRMENT IN HIV-1 INFECTED PATIENTS RECEIVING TENOFOVIR BASED ANTIRETROVIRAL THERAPY IN A SOUTH INDIAN HOSPITAL
Authors: Kumar A. Pramod , Parthasarathi G. , Sudheer A. P. , Mothi S. N. , Swamy V. H. T. , Rao Srirama
Published: May 2017

Objective: To identify the incidence and risk factors of tenofovir (TDF) induced nephrotoxicity among People Living with HIV/AIDS (PLHA) receiving TDF-based anti-retroviral therapy (ART) in a South Indian Hospital.Methods: A retrospective cohort study was conducted among HIV-infected ART naïve patients taking TDF as part of either a first-line or second-line ART between July 2013 and June 2015 at Asha kirana Hospital Mysore, India.Results: A total of 380 patients have been initiated on TDF-based ART. Out of these, 335 patients were on tenofovir+lamivudine+efavirenz, 30 patients were on the tenofovir+lamivudine+nevirapine regimen and 25 patients were on tenofovir+lamivudine+atazanavir/ritonavir regimen. Renal impairment was documented for 35 patients with 9.21% incidence. 34% of renal impaired patients had a severe impairment with eGFR<30 ml/min. Elderly patients (>61 y) had higher chances of developing TDF toxicity compared to adult patients (P=0.0018). Other possible risk factors for TDF-induced renal impairment was CD4>200 (P=0.003). TDF was withdrawn and substituted with Nucleoside Reverse Transcriptase Inhibitor (NRTI) drug following the diagnosis of renal impairment.Conclusion: TDF-associated renal impairment was not uncommon in real-life practice and considered as a frequent complication during treatment with TDF. Risk factors for developing renal impairment include increasing age and CD4>200 cells.
ELICITATION OF THERAPEUTIC POTENTIAL AND OXIDATIVE STRESS ASSESSMENT OF FENUGREEK SPROUTS UNDER UV IRRADIATION
Authors: Gupta Saran Kumar , Islam Najnin , Choudhuri Chandrani , Mandal Palash
Published: May 2017

Objective: To evaluate the effect of ultraviolet (UV) radiation on the therapeutical and oxidative stress status of fenugreek seedlings during the post-germination phase.Methods: The seeds of Trigonella foenum-graecum L. were subjected to UV radiation of different wavelengths UV 254 nm, UV 365 nm and the combination of 254 nm and 365 nm UV during the course of germination up to 96 h. Free radicals scavenging activity, in vitro antidiabetic activity as well as total phenol (TPC) and flavonoid (TFC) contents were evaluated up to four days of germination stages. Analysis of total activities of superoxide dismutase (SOD), peroxidase, catalase and NADPH oxidase (NOX) was conducted using non-denaturing polyacrylamide gel electrophoresis along with histochemical detection of H2O2 and superoxide radical localisation, lipid peroxidation and plasma membrane integrity was also performed.Results: Overall it was observed that the sprouts exposed to UV 365 nm exhibited a significant enhancement in free radical scavenging as well as antidiabetic activity at the 48h stage of germination. Interestingly highest phenol and flavonol content were also stimulated at the same stage by UV 365 nm. The effect of UV irradiation was evident on the localisation of H2O2 and superoxide radical. The on gel assay revealed that the total activities of the antioxidant enzymes were extensively elevated by UV irradiation.Conclusion: The results suggest that the UV irradiation technology can be implemented for the enhancement of nutraceutical properties of sprouts also UV exposure helps in the induction of the antioxidant enzyme system which may be beneficial for oxidative stress management in plants during germination phases.
RISK FACTORS, PREVALENCE AND DIAGNOSIS OF HUTCHISON GILFORD SYNDROME WITH SPECIAL REFERENCE TO CASE REPORTS
Authors: Sharma Bhawana , Sharma Priyanka , Joshi S. C.
Published: May 2017

Progeria also known Hutchinson–Gilford progeria syndrome (HGPS), is an extremely rare genetic disorder. The prevalence of HGPS is 1 in 4-8 million newborns. Progeria causes premature, rapid aging shortly after birth present within the first year of life. Recently, de novo point mutations in the Lmna gene at position 1824 of the coding sequence have been found in persons with HGPS. Lmna encodes lamin A and C, the A-type lamins, which are an important structural component of the nuclear envelope and play a role in protein processing. The most common HGPS mutation is located at codon 608 (G608G). This mutation responsible for creating a cryptic splice site within exon 11, which deletes a proteolytic cleavage site within the expressed mutant lamin A. In Progeria, gene mutation results in the deletion of a Zmpste24/FACE1 splice site in prelamin A, preventing end terminal cleavage. The result of this point mutation can be observed by the main clinical and radiological features include alopecia, thin skin hypoplasia of nails, loss of subcutaneous fat, and osteolysis. The common symptoms of HGPS is a loss of eyebrows and eyelashes which can observed in early childhood and due to receding hairline and blading can also observed. Generally, this patient has facial character include microganthia (small jaw), craniofacial disproportion, prominent eyes, scalp veins and alopecia (loss of hair), restricted joint mobility and severe premature atherosclerosis. Laboratory findings are unremarkable, with the exception of an increased urinary excretion of hyaluronic acid. There is presently no effective therapy is available for Hutchinson-Gilford progeria syndrome (HGPS) but, it is essential to monitor carefully cardiovascular and cerebrovascular disease So, Treatment usually includes low dose aspirin which helps prevent the atherothrombotic events, stroke and heart attacks by hindering platelet aggregation
EPIDEMIOLOGY AND OUTCOME AMONG SEVERE SEPSIS AND SEPTIC SHOCK PATIENTS IN A SOUTH INDIAN TERTIARY CARE HOSPITAL
Authors: Babu Merin , Menon Vidya P , P. Uma Devi
Published: May 2017

Objective: The objective of this research was to determine the prevalence of severe sepsis and septic shock and evaluate its outcome.Methods: This was a prospective, observational study, in which adult patients with severe sepsis or septic shock were included. Relevant information was collected from medical records and the hospital information system.Results: A total of 250 patients [mean age 57.2 y (range: 18 to 98 y)] was studied. The majority of the patients suffered from severe sepsis (81.2%). Most of the episodes occurred in males (75.2%). Major comorbidities included diabetes mellitus (51.2%), hypertension (44.8%) and chronic liver disease (30.4%). One hundred and seventy-eight patients (147 patients with severe sepsis and 31 patients with septic shock) had a positive culture with urine being the main site of infection. One hundred and two patients (40.8%) had a monomicrobial infection while seventy-six (30.4%) patients had a polymicrobial infection. Within the monomicrobial infections, the gram negative organisms predominated (54%). The mean hospital stay for patients with severe sepsis was 11.5 d. Mortality was noted in 79 patients (40 patients with septic shock and 39 patients with severe sepsis).Conclusion: The main causative pathogens were gram negative bacteria. Admissions meeting septic shock criteria have a high mortality rate. Hence, it is imperative to identify patients who are at high risk and treat them promptly to reduce serious consequences.
SYNTHESIS, ANTIMICROBIAL, ANTITUBERCULAR AND CHEMINFORMATIC STUDIES OF 2-(1-BENZOFURAN-2-YL)-N'-[(3Z)-2-OXO-1, 2-DIHYDRO-3H-INDOL-3-YLIDENE] QUINOLINE-4-CARBOHYDRAZIDE AND ITS DERIVATIVES
Authors: Santoshkumar S. , Satyanarayana N. D. , Anantacharya R. , Sameer P.
Published: May 2017

Objective: Synthesis of novel 2-(1-benzofuran-2-yl)-N'-[(3Z)-2-oxo-1, 2-dihydro-3H-indol-3-ylidene] quinoline-4-carbohydrazide and its derivatives for antimicrobial and antitubercular activity.Methods: Synthesis was carried out using the general method and the structures were confirmed by IR, 1H-NMR, [13]C-NMR and mass spectral analysis. The antibacterial activity was carried by agar well diffusion method, antifungal activity was performed by poison food technique and antitubercular activity was carried out by Microplate Alamar Blue Assay (MABA) method with the help of H37Rv. In silico absorption, distribution, metabolism, excretion, toxicity (ADMET) study of the drug, likeliness was carried out in ACD/lab-2.Results: The results revealed that at 25 mg/ml concentration, compounds 3a and 5a showed good antibacterial activity at 3.5±0.1, 3.8±0.3, 3.6±0.2 respectively against E. coli, K. pneumonia and S. typhimurium, when compared with drug streptomycin with similar concentration. The percentage of inhibition found at 50 µg/ml concentration, compounds 2b and 6a exhibited good antifungal activity at 53±1.15, 57±1.52 against A. flavus and C. neoformans, compared with standard drug fluconazole. The increase in activity was found to be dose dependent. The analogue 2a showed good antitubercular activity at 12.5±0.5 µg/ml, compounds 2b, 3a, 4a-b, 5a-b and 6a-b exhibited significant activity at 25±0.57 µg/ml and compound 3b showed moderate activity at 50±0.57 µg/ml. The mean value of P<0.05 were considered to be statistically significant. The absorption, distribution, metabolism, excretion and toxicity studies of the entitled molecules were analyzed and found to be in acceptable range.Conclusion: The study reveals that compounds containing benzofuran coupled nitrogen heterocycles are essential for activity as they possess excellent drug-like characteristics, suggesting to be potentially best inhibitor of H37Rv strain. The in silico ADME analysis also revealed that all the compounds were in acceptable range to obey the pharmacokinetic parameters.
Pengujian Adaptabilitas Beberapa Klon Karet Pada Elevasi Tinggi
Authors: Saputra Jamin , Wijaya Thomas , Ardika Risal , Stevanus Charlos Togi
Published: May 2017

Lahan yang ideal untuk pertumbuhan tanaman karet semakin terbatas sehingga banyak petani dan perusahaan mencari lahan pengembangan karet di daerah non tradisional seperti lahan pada elevasi > 500 m di atas permukaan laut (mdpl). Penelitian dilakukan di Muara Enim pada elevasi 760 mdpl. Penelitian bertujuan untuk mendapatkan informasi pertumbuhan dan produksi beberapa klon karet pada elevasi tinggi. Rancangan yang digunakan adalah rancangan acak kelompok dengan klon sebagai perlakuan dan diulang empat kali. Klon yang diuji adalah PB 260, RRIC 100, BPM 24, GT 1 dan IRR 39. Hasil penelitian menunjukkan, tanaman karet pada elevasi tinggi dengan perawatan sesuai anjuran akan mampu matang sadap pada umur 5 tahun. Hasil penelitian menunjukkan bahwa pertumbuhan klon karet paling cepat pada elevasi tinggi 760 mdpl secara berurutan adalah IRR 39, RRIC 100, PB260, BPM 24 dan GT 1. Produksi paling tinggi (g/p/s) pada elevasi tinggi 760 mdpl secara berurutan adalah PB 260, RRIC 100, BPM 24, GT 1 dan yang paling rendah klon IRR 39.Kata kunci: adaptabilitas, tanaman karet, elevasi tinggi
A imagem da capa
Authors: Perrotta Isabella
Published: May 2017

Neste número da Diálogo, a imagem da capa é uma criação caligráfica de Claudio Gil, professor do curso de Design da ESPM Rio nas disciplinas Criação de Fontes, Tipografia e Análise Estética.
Editorial
Authors: Perrotta Isabella
Published: May 2017

Interesse recente de agências governamentais, de organizações e da academia, o potencial de crescimento econômico de setores que desenvolvem atividades criativas é muito abrangente e ainda reserva vários aspectos a serem discutidos e também ações a serem implementadas. Esse quarto número da revista Diálogo com a Economia Criativa nos traz discussões abrangentes para o campo, e outras bastante específicas. Entre as abrangentes está um artigo que discute o processo de institucionalização do conceito de economia criativa no âmbito do governo federal, da sociedade civil e das universidades, a partir de indicadores de bases de dados diversos como sites do Governo Federal, CAPES, CNPQ, Observatórios de Economia Criativa, Ministério da Cultura e de organizações da sociedade civil.
Vulnérabilité des familles dirigées par une mère adolescente ou jeune adulte faisant l'objet d'une enquête menée par un service
de protection de l'enfance au Canada
Authors: Hovdestad W. , Shields M. , Williams G. , Tonmyr L.
Published: May 2017

Introduction

Les familles avec une jeune mère sont associées à un risque accru de mauvais traitements envers les enfants et de problèmes sociaux et de santé.

Méthodologie

Une analyse du chi carré effectuée sur des données combinées des services de protection de l’enfance issues de l’étude canadienne sur l’incidence des signalements de
cas de violence et de négligence envers les enfants (ECI-2003 et ECI-2008) a permis de comparer 284 mères adolescentes (18 ans et moins) et 800 jeunes mères (19 à 21 ans) et leurs
familles à 5 752 familles avec une mère de 22 ans ou plus.

Résultats

Vingt-six pour cent des jeunes mères avaient 18 ans ou moins. La plupart recevaient de l’aide sociale comme principale source de revenu (68 % des familles avec une
mère adolescente et 57 % des familles avec une mère jeune adulte contre 36 % des familles avec une mère de 22 ans ou plus). Les mères adolescentes et les mères jeunes adultes
étaient plus susceptibles d’avoir été placées dans leur enfance que les mères de 22 ans ou plus (31 % et 23 % contre 10 %) et présentaient plus fréquemment des facteurs de
risque tels que l’alcoolisme (25 % et 23 % contre 18 %) ou un manque de soutien social (46 % et 41 % contre 37 %). Les pourvoyeurs secondaires de soins dans les familles avec de
jeunes mères étaient aussi associés à un plus grand nombre de facteurs de risque. Les familles de mères adolescentes ou jeunes adultes couraient un risque plus élevé de décision
de placement de l’enfant pendant l’enquête (29 % et 27 % contre 17 %). Les mères couraient toutes le même risque d’être victimes de violence familiale et de présenter des problèmes
de santé mentale.

Conclusion

Dans cet échantillon de familles à risque élevé, les risques étaient plus importants pour les familles avec de jeunes mères que pour les familles auxquelles on les
avait comparées. Le jeune âge de la mère pourrait être un bon critère pour repérer les familles nécessitant des interventions ciblées.
Adapting, piloting and evaluating complex public health interventions: lessons learned from the Nurse–Family Partnership in Canadian public health settings
Authors: Jack S. M. , Catherine N. , Gonzalez A. , MacMillan H. L. , Sheehan D. , Waddell C.
Published: May 2017

Introduction

The Nurse–Family Partnership (NFP) is a home-visit program for young
and first-time, socially and economically disadvantaged mothers. Evidence from three
United States randomized controlled trials (RCTs) on the effectiveness of this
intervention at improving pregnancy outcomes, improving child health and development,
and increasing maternal economic self-sufficiency is robust. However, the
effectiveness of the NFP in Canada, with its different health and social care context,
needs to be determined. The purpose of this article is to describe the complex process for
moving the NFP from the research arena to full implementation in Canada.

Methods

This process of evaluation in Canada includes (1) adapting the intervention;
(2) piloting the intervention in small-scale feasibility and acceptability studies; and
(3) conducting an RCT and process evaluation through a study called the British Columbia
Healthy Connections Project (BCHCP). This large-scale evaluation also creates an opportunity
to expand the NFP evidence base by conducting an additional study to examine potential
biological mechanisms linking intervention and behavioural outcomes in children.

Results

Adaptation of the NFP home-visit materials is a continuous process. A pilot
project determined that it was feasible to enrol eligible women into the NFP. This pilot
also determined that, in Canada, it was most appropriate for public health agencies to
implement the NFP and for public health nurses to deliver the intervention. Finally, the
pilot showed that this intensive home-visit program was acceptable to clients, their
family members and health care providers. Through the BCHCP, the next steps—the RCT and process evaluation—are currently underway.
The BCHCP will also set the foundation for long-term evaluation of key public health outcomes in a highly vulnerable population of families. The function of home-visit programs
should not be viewed in isolation. Rather, their potential can be maximized when they collaborate and share information
with other agencies to provide better services for first-time mothers.
Points de vue de professionnels de la santé et des services sociaux sur un programme de visites à domicile destiné aux jeunes mères d’un premier enfant
Authors: Li S.-A. , Jack S. M. , Gonzalez A. , Duku E. , MacMillan H. L.
Published: May 2017

Introduction

On sait peu de choses sur ce que pensent les professionnels de la santé et des services sociaux des programmes à long terme de visites à domicile pour les nouvelles
mères à faible revenu. Cette étude fait état des expériences et des points de vue de fournisseurs de services communautaires qui orientent les mères participant au Nurse-Family
Partnership (NFP) – un programme de visites à domicile par une infirmière auprès de cette population cible – vers le programme lui-même ou qui interviennent directement dans le
cadre de celui-ci.

Méthodologie

L’étude s’est déroulée en deux phases. La phase I a consisté en une analyse secondaire de données qualitatives issues d’un échantillon de 24 entrevues individuelles
dirigées avec des fournisseurs de soins communautaires, cette démarche s’inscrivant dans le cadre d’une étude de cas plus vaste réalisée à Hamilton (Ontario, Canada) et destinée à
examiner les moyens à mettre en oeuvre pour accroître la recevabilité du NFP. La phase II, à laquelle ont pris part 4 participants, a consisté en une description qualitative des
3 thèmes relevés lors de la phase I, thèmes qui ont été approfondis au moyen d’entrevues individuelles semi-structurées menées auprès de certains fournisseurs de soins de santé et
de services sociaux communautaires.

Résultats

Le NFP est perçu dans l’ensemble comme un programme comblant une lacune importante dans les services dispensés aux nouvelles mères. Des échanges fréquents entre le
NFP et les organismes communautaires offrant déjà des services à ces mères pourraient contribuer à en améliorer le processus d’orientation, à éviter leur chevauchement et à en
faciliter l’accès. Ces résultats contribuent à mieux définir les composantes nécessaires au succès de l’intégration d’un programme de visites à domicile au réseau déjà en place
de services communautaires.

Conclusion

Le rôle des programmes de visites à domicile ne doit pas être envisagé isolément. Au contraire, le potentiel de ceux-ci est optimisé par la collaboration et l’échange
d’information avec d’autres organismes afin d’offrir de meilleurs services aux mères d’un premier enfant.
Miracles and Violations of Laws of Nature
Authors: Saudek Daniel
Published: May 2017

The aim of this article is to spell out the relationship between miracles and violations of laws of nature. I argue that the former do not necessarily entail the latter, even in the case of the type of miraculous event which cannot be brought about by natural operations alone. The idea that they do is based on a deterministic assumption which is too often overlooked. The article also explores the reverse implication, i.e. the question whether violations of laws of nature entail miracles. It turns out that there are conceptual difficulties in defining what sort of events would qualify as such violations in the first place, but that a more general notion of God’s action contravening nature is viable. However, there are theological reasons against the assumption that God ever acts in this way.
An Epistemological Corrective to Doctrines of Assurance
Authors: Rutledge Jonathan C.
Published: May 2017

Many Christian traditions affirm a doctrine of assurance. According to this doctrine, those who are saved have assurance of their own salvation; that is, the doctrine of assurance tells us that the elect can know their status as elect. In this paper, I explore two developments of the doctrine of assurance by theologians (i.e. John Calvin & Kenneth Keathley) and argue that they fail to accommodate the fallibilistic nature of human knowing. I then develop a fallibilistic doctrine of assurance, which makes such assurance available to most Christians, and respond to an objection from the camp of pragmatic encroachment.
Una mirada crítica sobre la realidad de la formación universitaria del profesional de Enfermería en el tercer milenio
Authors: Remuzgo Artezano Anika
Published: May 2017

Comprender el término calidad en la formación universitaria requiere una explicación en diferentes dimensiones y ejes fundamentales, desde donde se puede reconocer la calidad de un sistema educativo. Ello implica reconocer que en lugar de un problema teórico, nos enfrentamos con el paradigma de distinguir que la calidad es parte ineludible del compromiso profesional académico, de poner a disposición de los tomadores de decisiones un marco de acción para lograr la excelencia del proceso educativo, con la formación de un profesional competente, capaz de enfrentar los retos que se le presenten en el día a día. En Enfermería esto es vital, puesto que se tiene que enfrentar en su quehacer diario a tomar decisiones parabrindar un cuidado óptimo al individuo y la población; sin embargo, como se está brindando la formación de los futuros enfermeros, un tema que meditar y tratar de solucionarlo en la brevedad posible.
El saber profesional de una maestra de Infantil
Authors: Orozco Martínez Susana
Published: May 2017

El artículo expone los saberes y práctica profesional de María, maestra de Educación Infantil de una escuela pública de Cataluña, a cargo de 24 estudiantes (13 niñas y 11 niños). La recolección de datos posibilita profundizar en sus experiencias pedagógicas y en el proceso educativo que pone en marcha, y que contribuyen en la creación y desarrollo de una relación educativa caracterizada por la atención a las necesidades individuales y a la singularidad de sus alumnos, desde un acompañamiento, acogimiento y cuidado de lo que se vive en el aula.
L’entrée dans la carrière d’enseignant-chercheur en GRH
Authors: Point Sébastien , Akremi Assaâd El , Igalens Jacques
Published: May 2017

L’entrée dans la carrière d’enseignant-chercheur pour les nouveaux docteurs en gestion passe très souvent par l’accès à un premier poste dans une université ou unebusiness school. À partir d’une analyse du profil et du devenir de 326 docteurs en GRH poursuivant une carrière académique en France, cet article propose de mettre en exergue les facteurs susceptibles d’impacter l’accès à un poste dans une université ou unebusiness school. Si un âge avancé est lié à un accès à un poste dans unebusiness school, plus le statut du directeur de thèse est élevé ou encore plus la réputation scientifique de l’établissement est forte, plus le docteur en GRH semble s’orienter plus facilement vers un premier poste dans une université.
Synthesis, structures, photophysical and catalytic properties of benzothienyl iridium(III) complexes
Authors: Ye Si-Pei , Xie Yi-Bi , Zhao Ke-Yan , Liu Yang , Yang Jian , Li De-Jiang , Wang Long
Published: May 2017

Bisbenzothienyl iridium(III) complexes, [Ir(bt)2(PR3)]X (bt: 2-phenylbenzo[ d]thiazole, R = n-Bu or Ph, X = OTf, BF4 or SbF6) are reported, two of which, (R = n-Bu or Ph, X = OTf), have been characterised by X-ray crystallography. The complexes are thermally stable and their photophysical properties are presented, together with their catalytic activity in the “borrowing hydrogen reaction” of alcohols with amines.
Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral Cortex
Authors: Dudok Jacobus , Leonards Pim , Wijnholds Jan
Published: May 2017

The migration of neuronal cells in the developing cerebral cortex is essential for proper development of the brain and brain networks. Disturbances in this process, due to genetic abnormalities or exogenous factors, leads to aberrant brain formation, brain network formation, and brain function. In the last decade, there has been extensive research in the field of neuronal migration. In this review, we describe different methods and approaches to assess and study neuronal migration in the developing cerebral cortex. First, we discuss several genetic methods, techniques and genetic models that have been used to study neuronal migration in the developing cortex. Second, we describe several molecular approaches to study aberrant neuronal migration in the cortex which can be used to elucidate the underlying mechanisms of neuronal migration. Finally, we describe model systems to investigate and assess the potential toxicity effect of prenatal exposure to environmental chemicals on proper brain formation and neuronal migration.
Exploring Promising Catalysts for Chemical Hydrogen Storage in Ammonia Borane: A Density Functional Theory Study
Authors: Bandaru Sateesh , English Niall , Phillips Andrew , MacElroy J.
Published: May 2017

Density functional theory (DFT) has been applied to study potential ammonia borane (AB) dehydrogenation pathways via new bifunctional ruthenium-based catalysts, alongside their computationally-designed iron-based counterparts (i.e., four catalysts), using the wB97XD (dispersion-included) functional. The efficiency of each catalyst was under scrutiny based on the addition of ammonia borane, with a focus on the associated activation-energy barriers, whilst hydrogen release from the catalyst was also studied in detail. Here, natural-population analysis charges were key quantities of interest. It was found that the iron-based catalysts display more promising dehydrogenation energy barriers vis-
Riboflavin Responsive Mitochondrial Dysfunction in Neurodegenerative Diseases
Authors: Udhayabanu Tamilarasan , Manole Andreea , Rajeshwari Mohan , Varalakshmi Perumal , Houlden Henry , Ashokkumar Balasubramaniem
Published: May 2017

Mitochondria are the repository for various metabolites involved in diverse energy-generating processes, like the TCA cycle, oxidative phosphorylation, and metabolism of amino acids, fatty acids, and nucleotides, which rely significantly on flavoenzymes, such as oxidases, reductases, and dehydrogenases. Flavoenzymes are functionally dependent on biologically active flavin adenine dinucleotide (FAD) or flavin mononucleotide (FMN), which are derived from the dietary component riboflavin, a water soluble vitamin. Riboflavin regulates the structure and function of flavoenzymes through its cofactors FMN and FAD and, thus, protects the cells from oxidative stress and apoptosis. Hence, it is not surprising that any disturbance in riboflavin metabolism and absorption of this vitamin may have consequences on cellular FAD and FMN levels, resulting in mitochondrial dysfunction by reduced energy levels, leading to riboflavin associated disorders, like cataracts, neurodegenerative and cardiovascular diseases, etc. Furthermore, mutations in either nuclear or mitochondrial DNA encoding for flavoenzymes and flavin transporters significantly contribute to the development of various neurological disorders. Moreover, recent studies have evidenced that riboflavin supplementation remarkably improved the clinical symptoms, as well as the biochemical abnormalities, in patients with neuronopathies, like Brown-Vialetto-Van-Laere syndrome (BVVLS) and Fazio-Londe disease. This review presents an updated outlook on the cellular and molecular mechanisms of neurodegenerative disorders in which riboflavin deficiency leads to dysfunction in mitochondrial energy metabolism, and also highlights the significance of riboflavin supplementation in aforementioned disease conditions. Thus, the outcome of this critical assessment may exemplify a new avenue to enhance the understanding of possible mechanisms in the progression of neurodegenerative diseases and may provide new rational approaches of disease surveillance and treatment.
A General-Purpose Graphics Processing Unit (GPGPU)-Accelerated Robotic Controller Using a Low Power Mobile Platform
Authors: Rizvi Syed , Cabodi Gianpiero , Patti Denis , Gulzar Muhammad
Published: May 2017

Robotic controllers have to execute various complex independent tasks repeatedly. Massive processing power is required by the motion controllers to compute the solution of these computationally intensive algorithms. General-purpose graphics processing unit (GPGPU)-enabled mobile phones can be leveraged for acceleration of these motion controllers. Embedded GPUs can replace several dedicated computing boards by a single powerful and less power-consuming GPU. In this paper, the inverse kinematic algorithm based numeric controllers is proposed and realized using the GPGPU of a handheld mobile device. This work is the extension of a desktop GPU-accelerated robotic controller presented at DAS’16 where the comparative analysis of different sequential and concurrent controllers is discussed. First of all, the inverse kinematic algorithm is sequentially realized using Arduino-Due microcontroller and the field-programmable gate array (FPGA) is used for its parallel implementation. Execution speeds of these controllers are compared with two different GPGPU architectures (Nvidia Quadro K2200 and Nvidia Shield K1 Tablet), programmed with Compute Unified Device Architecture (CUDA) computing language. Experimental data shows that the proposed mobile platform-based scheme outperforms the FPGA by 5× and boasts a 100× speedup over the Arduino-based sequential implementation.
Revealing Implicit Assumptions of the Component Substitution Pansharpening Methods
Authors: Xie Bin , Zhang Hankui , Huang Bo
Published: May 2017

The component substitution (CS) pansharpening methods have been developed for almost three decades and have become better understood recently by generalizing them into one framework. However, few studies focus on the statistical assumptions implicit in the CS methods. This paper reveals their implicit statistical assumptions from a Bayesian data fusion framework and suggests best practices for histogram matching of the panchromatic image to the intensity image, a weighted summation of the multispectral images, to better satisfy these assumptions. The purpose of histogram matching was found to make the difference between the high-resolution panchromatic and intensity images as small as possible, as one implicit assumption claims their negligible difference. The statistical relationship between the high-resolution panchromatic and intensity images and the relationship between their corresponding low-resolution images are the same, as long as the low resolution panchromatic image is derived by considering the modulation transfer functions of the multispectral sensors. Hence, the histogram-matching equation should be derived from the low-resolution panchromatic and intensity images, but not derived from the high-resolution panchromatic and expanded low-resolution intensity images. Experiments using three example CS methods, each using the two different histogram-matching equations, was conducted on the four-band QuickBird and eight-band WorldView-2 top-of-atmosphere reflectance data. The results verified the best practices and showed that the histogram-matching equation derived from the high-resolution panchromatic and expanded low-resolution intensity images provides more-blurred histogram-matched panchromatic image and, hence less-sharpened pansharpened images than that derived from the low-resolution image pair. The usefulness of the assumptions revealed in this study for method developers is discussed. For example, the CS methods can be improved by satisfying the assumptions better, e.g., classifying the images into homogenous areas before pansharpening, and by changing the assumptions to be more general to address their deficiencies.
Health-Promoting Managerial Work: A Theoretical Framework for a Leadership Program that Supports Knowledge and Capability to Craft Sustainable Work Practices in Daily Practice and During Organizational Change
Authors: Dellve Lotta , Eriksson Andrea
Published: May 2017

The aim of this article is to describe a theoretical framework, i.e., theoretical underpinnings and pedagogical principles, for leadership programs that support managers’ evidence-based knowledge of health-promoting psychosocial work conditions, as well as their capability to apply, adapt, and craft sustainable managerial work practices. First, the theoretical framing is introduced, i.e., a system theory that integrates key work conditions with a practical perspective on managerial work and organization. Second, pedagogical principles and measures for leaders’ training in integrated handling across system levels are described. Last, we present summarized results from an intervention study applying the theoretical framework and pedagogical principles. The complexity of interactions among different factors in a work system, and the variety in possible implementation approaches, presents challenges for the capability of managers to craft sustainable and health-promoting conditions, as well as the evaluation of the program components. Nevertheless, the evaluation reveals the strength of the program, in providing holistic and context-sensitive approaches for how to train and apply an integrative approach for improving the work environment.
Circulating Tumor Cells Predict Prognosis Following Tyrosine Kinase Inhibitor Treatment in EGFR-Mutant Non-Small Cell Lung Cancer Patients
Authors: Yang Baohong , Qin Aiying , Zhang Kongyuan , Ren Haipeng , Liu Shuzhen , Liu Xiaolei , Pan Xiangpo , Yu Guohua
Published: May 2017

Epithelial growth factor receptor (EGFR) mutations are present in 10%‐26% of non-small cell lung cancer (NSCLC) tumors and are associated with the response to tyrosine kinase inhibitors (TKIs). This study aimed to detect and quantify the presence of circulating tumor cells (CTCs)
in EGFR-mutant NSCLC patients and investigate their possible role in providing prognostic information. Enrolled patients received erlotinib (150 mg) or gefitinib (250 mg) orally once daily as the first-line treatment. Serial blood samples were taken at baseline (CTC-d0) and on day 28 (CTC-d28)
following the initiation of erlotinib/gefitinib for detection of CTCs using the CellSearch system. CTCs ≥2 were found in 47/107 (44%) and CTCs ≥5 in 17/107 (15%). The CTC measurements were dichotomized as favorable (<5 CTCs) and unfavorable (≥5 CTCs) groups. The median progression-free
survival (PFS) interval for patients in the favorable group at baseline was 11.1 months, significantly longer than the median PFS time of 6.8 months achieved by patients in the unfavorable group (p = 0.009). Patients in the favorable group on day 28 exhibited significantly
longer PFS compared with patients in the unfavorable group (11.6 vs. 6.3 months; p < 0.0001). In univariate analysis, CTC-d0 ≥ 5 versus CTC-d0 = 0‐4 was significantly associated with poor PFS and time-to-treatment failure (TTF).
CTC-d28 ≥ 5 versus CTC-d28 = 0‐4 was significantly associated with a poor PFS outcome. CTC-d0 and CTC-d28 remained independent poor prognostic markers in the stepwise multivariate analysis. Our study indicates that the CTC count is a prognostic factor
for PFS and TTF outcomes in patients with advanced EGFR-mutant NSCLC.
Cathepsin F Knockdown Induces Proliferation and Inhibits Apoptosis in Gastric Cancer Cells
Authors: Ji Ce , Zhao Ying , Kou You-Wei , Shao Hua , Guo Lin , Bao Chen-Hui , Jiang Ben-Chun , Chen Xin-Ying , Dai Jing-Wei , Tong Yu-Xin , Yang Ren , Sun Wei , Wang Qiang
Published: May 2017

Gastric cancer (GC) is one of the most common cancers in the world. The cathepsin F (CTSF) gene has recently been found to participate in the progression of several types of cancer. However, the clinical characteristics and function of CTSF in GC as well as its molecular mechanisms
are not clear. Six GC cell lines and 44 paired adjacent noncancerous and GC tissue samples were used to assess CTSF expression by quantitative polymerase chain reaction (qPCR). We used lentivirus-mediated small hairpin RNA (Lenti-shRNA) against CTSF to knock down the expression of CTSF in
GC cells. Western blot and qPCR were used to analyze the mRNA and related protein expression. The biological phenotypes of gastric cells were examined by cell proliferation and apoptosis assays. Microarray-based mRNA expression profile screening was also performed to evaluate the potential
molecular pathways in which CTSF may be involved. The CTSF mRNA level was associated with tumor differentiation, depth of tumor invasion, and lymph node metastasis. Downregulation of CTSF expression efficiently inhibited apoptosis and promoted the proliferation of GC cells. Moreover, a total
of 1,117 upregulated mRNAs and 1,143 downregulated mRNAs were identified as differentially expressed genes (DEGs). Further analysis identified the involvement of these mRNAs in cancer-related pathways and various other biological processes. Nine DEGs in cancer-related pathways and three downstream
genes in the apoptosis pathway were validated by Western blot, which was mainly in agreement with the microarray data. To our knowledge, this is the first report investigating the effect of CTSF on the growth and apoptosis in GC cells and its clinical significance. The CTSF gene may function
as a tumor suppressor in GC and may be a potential therapeutic target in the treatment of GC.
Un penseur de la répétition et du retour : Jean-François Mattéi
Authors: Rappin Baptiste
Published: May 2017

En hommage à Jean-François Mattéi, décédé brutalement en mars 2014, on cherche à dégager le ressort de son œuvre, placée sous le signe de la répétition et du retour : répétition de la question de l’être, mouvement d’exil et de retour de l’âme du philosophe, à l’image des mouvements ascendants puis descendants que met en scène le mythe platonicien de la caverne. Ce thème a une provenance mythique : pour Mattéi, Ulysse semble bien l’archétype du philosophe, et l’Odyssée le modèle de la philosophie.
Don Juan : ses émules, victimes, accusateurs, et ses créateurs
Authors: Morin-Bompart Michelle
Published: May 2017

Le chef-d’œuvre du moine espagnol est à l’origine du mythe de Don Juan. Est-ce un libertin ? Alberto Eiguer a fait une remarquable analyse de ce séducteur invétéré qui refuse les contraintes, ne peut s’attacher car c’est perdre son indépendance. Pour Michel Fain, Don Juan et ses émules présentent une hypersexualité. Grâce à leur art de séduire, ils bernent les maris et font jouir comme jamais les femmes. Le courant tendre refoulé, seul subsiste le courant sexuel vers des objets peu estimés. Trois œuvres mythiques L’abuseur de Séville ou le convive de pierre de Tirso de Molina, Dom Juan ou le festin de pierre de Molière et Don Giovanni ou le dissolu puni de Da Ponte (Mozart) montreront les différences entre les groupes des émules de Don Juan, leurs victimes et leurs accusateurs. Un lien unit le groupe de leurs créateurs : ce sont tous des émules de Don Juan, fascinés par lui, chef de la horde qui tue le père pour prendre le pouvoir et posséder les femmes.
Workers vs Machines: Ottoman Tunis between Industrialisation and Colonisation
Authors: Lafi Nora
Published: May 2017

The Ottoman province of Tunis between the 1850s and its integration into the French colonial sphere in the 1880s, was marked by the emergence of new issues directly arising from an international configuration undergoing profound change. This chapter aims to analyse the relationship between economic development, geopolitics and local issues in the last decades during which the province belonged to the Empire. It will home in on an emblematic conflict, one related to the fate of workers and artisans in fez factories as they protested against what they saw as unfair competition imposed by the European powers, and against the industrialisation that followed the mechanisation of production. These new operating conditions, in a market subject to the growing dominance of foreign trade and to instability in local production, gave rise to many protests. This chapter endeavours to compare and contrast the different levels and scales of this sector, to explain the impact of a new global dimension on local balances and the vectors of a new form of foreign interference. These conflicts also involved different ways of negotiating the reformed relationship between the Ottoman Empire and its province of Tunis in the face of the threat of ever-increasing foreign domination and colonisation. Focusing on the voices of the most modest local players, who spoke out to condemn the deterioration of their living conditions, and on the local and international context, the chapter aims to reveal the dynamic interrelation between different levels and issues, and individual destinies and wider perspectives, at a time of great historical change.
An Investigation of Educational Use of Information and Communication Technology from the Perspectives of Ghanaian Students
Authors: Buabeng-Andoh Charles
Published: May 2017

The purpose of this study was to study undergraduate students' acceptance and use of ICT in classrooms. A total of 361 students from four universities participated in the study. Survey questionnaires which comprised both closed-ended and open-ended questions were used to collect data. Descriptive statistics, Pearson correlation, repeated-measures of Analysis of variance and multiple regression were used to analyze the findings. The study revealed that students use technology for personal purposes rather than for instructional purposes. Despite, students' high acceptance of technology, their technology integration into learning has remained low. The analysis showed that students believing that technology can improve their relationship with other students significantly contributed to their acceptance of technology in schools. Understanding students' acceptance and their experiences of technology use offer insights into their integration of technology into learning.