bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Splice Site Pathogenic Variant of EFTUD2 Is Associated with Mandibulofacial Dysostosis with Microcephaly and Extracranial Symptoms in Korea
Authors: Kim So Young , Lee Da-hye , Han Jin Hee , Choi Byung Yoon
Published: May 2020

Elongation factor Tu guanosine-5’-triphosphate (GTP) binding domain containing 2 (EFTUD2) encodes a major component of the spliceosomal GTPase and, if mutated, causes mandibulofacial dysostosis with microcephaly (MFDM; MIM#610536). Despite the increasing number of potentially pathogenic variants reported in the literature, most previous studies have relied solely on in silico prediction of the pathogenic potential of EFTUD2 variants, which may result in misclassification of the variant’s pathogenicity. Given the importance of the functional verification of EFTUD2 variants, we identified a novel splice donor site variant, c.271+1G>A of EFTUD2, whose pathogenicity was clearly verified at the RNA level using a minigene assay. A child with MFDM, mixed hearing loss, microcephaly, and a congenital cardiac defect was identified with this variant, which arose in a de novo fashion. The minigene assay showed erroneous integration of the 118 bp IVS3 of EFTUD2 exclusively among the c.271+1G>A variant clone. We first applied the minigene assay to identify the splice function of a splice site variant of EFTUD2, thereby allowing for in vitro functional verification of splice site variants in EFTUD2.
Introduction to a New Open-Access Journal by MDPI: Electronic Materials
Authors: Pisula Wojciech
Published: May 2020

Electronic materials are ubiquitous and essential for the daily lives of billions of people [...]
Composition, Ageing and Herbicidal Properties of Wood Vinegar Obtained through Fast Biomass Pyrolysis
Authors: Aguirre Juan Luis , Baena Juan , Martín María Teresa , Nozal Leonor , González Sergio , Manjón José Luis , Peinado Manuel
Published: May 2020

Lignocellulosic biomass pyrolysis could be an economically feasible option for forest management as it reduces the need to burn litter and helps in fire prevention thus avoiding the release of carbon dioxide and other greenhouse gases into the atmosphere. This study characterises wood vinegar (WV) obtained via a continuous fast pyrolysis process in terms of its composition, ageing and herbicidal properties. The aqueous WV fraction had a moisture content of 84% in weight and contained more than 200 compounds. Acetic acid, hydroxyacetaldehyde and hydroxyacetone were the major components. No significant differences were found in WV composition according to the starting material (poplar, pine, pruning litter, forest waste). No residual aromatic polycyclic compounds that could be harmful to the environment were detected. In a series of climate-controlled glass chamber experiments, the WV proved to be as effective an inhibitor of seed germination and seedling growth as a contact herbicide acting against weeds, especially through aerial contact. Sprayed WV concentrations of 50, 75 and 100 vol. % were effective against all plant species tested. This product could therefore be of commercial interest and help make biomass pyrolysis economically viable, once environmental exposure limits and the safe application for agricultural and urban use of this product have been established.
Wind Energy Implementation to Mitigate Wildfire Risk and Preemptive Blackouts
Authors: Haces-Fernandez Francisco
Published: May 2020

Damages caused by wildfires in California due to transmission line failures have increased significantly in recent years. Curtailment of electric service in areas under fire threat has been implemented to avoid these wildfires. Results from this research indicated that 24% of California’s cities are at risk of wildfire, while 52% are at risk of blackout. These blackouts have resulted in significant financial losses and risk to life and health. Undergrounding current transmission lines has been proposed as a long-term solution. However, undergrounding lines would take decades to complete and increase average monthly electric bills from $80 to $260. This research investigated shortening the length of the electricity supply chain, supplying affected communities with onshore and offshore wind energy. Results showed good wind energy potential in locations near affected cities. Distance analyses revealed that more than two hundred cities (population 5.5 million) can be served by existing wind farms located at less than 50 km. Future offshore wind turbines could generate high power output (capacity factor >50% for significant periods). An analysis of diverse locations along California’s coast indicated that just one offshore wind farm could serve more than a hundred cities with cumulative population larger than one million.
Development of a Model for the Estimation of the Energy Consumption Associated with the Transportation of CO2 in Pipelines
Authors: Jackson Steven
Published: May 2020

All Carbon Capture and Storage (CCS) projects require the transportation of CO2 from a source to a storage location. Although, a compressor and a large diameter pipeline is the normal method used to achieve this, liquefaction, shipping and pumping is sometimes attractive. Identifying the economic optimum is important for all CCS projects, minimizing energy consumption is also important because it corresponds to a resource efficiency in fossil-fuel based projects. This article describes the development and validation of a model that estimates the energy consumption associate with CO2 transportation using the geographic location of the source and the reservoir to incorporate ambient temperature and bathymetry data. The results of the validation work show an average absolute temperature and pressure error less than 1 °C and 1 bar compared to a reference model. The model has been developed using openly accessible data and is made available in a repository for open research data.
Design Evaluation for a Finned-Tube CO2 Gas Cooler in Residential Applications
Authors: Alexopoulos Charalampos , Aljolani Osama , Heberle Florian , Roumpedakis Tryfon C. , Brüggemann Dieter , Karellas Sotirios
Published: May 2020

Towards the introduction of environmentally friendlier refrigerants, CO2 cycles have gained significant attention in cooling and air conditioning systems in recent years. In this context, a design procedure for an air finned-tube CO2 gas cooler is developed. The analysis aims to evaluate the gas cooler design incorporated into a CO2 air conditioning system for residential applications. Therefore, a simulation model of the gas cooler is developed and validated experimentally by comparing its overall heat transfer coefficient. Based on the model, the evaluation of different numbers of rows, lengths, and diameters of tubes, as well as different ambient temperatures, are conducted, identifying the most suitable design in terms of pressure losses and required heat exchange area for selected operational conditions. The comparison between the model and the experimental results showed a satisfactory convergence for fan frequencies from 50 to 80 Hz. The absolute average deviations of the overall heat transfer coefficient for fan frequencies from 60 to 80 Hz were approximately 10%. With respect to the gas cooler design, a compromise between the bundle area and the refrigerant pressure drop was necessary, resulting in a 2.11 m2 bundle area and 0.23 bar refrigerant pressure drop. In addition, the analysis of the gas cooler’s performance in different ambient temperatures showed that the defined heat exchanger operates properly, compared to other potential gas cooler designs.
Application of the Swarm Intelligence Algorithm for Reconstructing the Cooling Conditions of Steel Ingot Continuous Casting
Authors: Zielonka Adam , Słota Damian , Hetmaniok Edyta
Published: May 2020

This paper presents a proposal to apply one of the swarm intelligence algorithms, the artificial bee colony (ABC) algorithm, to solve the inverse problem of steel ingot continuous casting. The discussed task consists of retrieving the cooling conditions of the process on the basis of temperature measurements and by taking into account the macrosegregation phenomenon. The examined process was modeled by using the mathematical model of solidification within the temperature interval. The solution method was based on the implicit scheme of the finite difference method supplemented by the procedure of correcting the field of temperature in the vicinity of liquidus and solidus curves, which was then used for solving the appropriate direct problem. The computational example, illustrating the stability and accuracy of the proposed method, is also presented in the paper.
Increasing Compressed Gas Energy Storage Density Using CO2–N2 Gas Mixture
Authors: Abuheiba Ahmad , Ally Moonis R. , Smith Brennan , Momen Ayyoub
Published: May 2020

This paper demonstrates a new method by which the energy storage density of compressed air systems is increased by 56.8% by changing the composition of the compressed gas to include a condensable component. A higher storage density of 7.33 MJ/m3 is possible using a mixture of 88% CO2 and 12% N2 compared to 4.67 MJ/m3 using pure N2. This ratio of gases representing an optimum mixture was determined through computer simulations that considered a variety of different proportions from pure CO2 to pure N2. The computer simulations are based on a thermodynamic equilibrium model that predicts the mixture composition as a function of volume and pressure under progressive compression to ultimately identify the optimal mixture composition (88% CO2 + 12% N2). The model and simulations predict that the optimal gas mixture attains a higher energy storage density than using either of the pure gases.
Properties of Oak Roundwood with and without Frost Cracks
Authors: Mania Przemysław , Tomczak Arkadiusz
Published: May 2020

The aim of this study was to examine certain properties of sessile oak wood (Quercus petraea (Matt.) Liebl.) with frost cracks, such as density (ρ), modulus of rupture (MOR), modulus of elasticity (MOE), and compressive strength in all anatomical directions and to compare it with control trees without frost cracks. Oak with frost cracks had a higher wood density (ρ = 765 kg × m−3) than the control (ρ = 650 kg × m−3). However, despite its lower density, the control oak was characterized by noticeably better mechanical parameters, with the exception of the compressive strength in radial and tangential directions. Differences in mechanical parameters reached up to 26%. The tests were performed on wood taken from trees with frost cracks that formed over 10 years to several decades ago. Frost cracks can render wood vulnerable to fungi growth, which leads to rotting and discoloration. Differences in strength were found on samples with no visible signs of decay, as they were cut at a distance from the crack. Nonetheless, the observed differences in strength allowed us to conclude that the shreds of fungi, as well as decay, may occur in the entire volume of the frost-damaged log. Such wood is, therefore, of a lower quality than that made of logs without any frost damage. Trees with frost cracks should be progressively be felled during the periodic intermediate cutting, as their wood quality may systematically deteriorate over the years.
What Is Threatening Forests in Protected Areas? A Global Assessment of Deforestation in Protected Areas, 2001–2018
Authors: Wade Christopher M. , Austin Kemen G. , Cajka James , Lapidus Daniel , Everett Kibri H. , Galperin Diana , Maynard Rachel , Sobel Aaron
Published: May 2020

The protection of forests is crucial to providing important ecosystem services, such as supplying clean air and water, safeguarding critical habitats for biodiversity, and reducing global greenhouse gas emissions. Despite this importance, global forest loss has steadily increased in recent decades. Protected Areas (PAs) currently account for almost 15% of Earth’s terrestrial surface and protect 5% of global tree cover and were developed as a principal approach to limit the impact of anthropogenic activities on natural, intact ecosystems and habitats. We assess global trends in forest loss inside and outside of PAs, and land cover following this forest loss, using a global map of tree cover loss and global maps of land cover. While forests in PAs experience loss at lower rates than non-protected forests, we find that the temporal trend of forest loss in PAs is markedly similar to that of all forest loss globally. We find that forest loss in PAs is most commonly—and increasingly—followed by shrubland, a broad category that could represent re-growing forest, agricultural fallows, or pasture lands in some regional contexts. Anthropogenic forest loss for agriculture is common in some regions, particularly in the global tropics, while wildfires, pests, and storm blowdown are a significant and consistent cause of forest loss in more northern latitudes, such as the United States, Canada, and Russia. Our study describes a process for screening tree cover loss and agriculture expansion taking place within PAs, and identification of priority targets for further site-specific assessments of threats to PAs. We illustrate an approach for more detailed assessment of forest loss in four case study PAs in Brazil, Indonesia, Democratic Republic of Congo, and the United States.
Genetic Diversity and Evolutionary Relationships of Chinese Pepper Based on nrDNA Markers
Authors: Feng Shijing , Niu Jinshuang , Liu Zhenshan , Tian Lu , Wang Xiangyuan , Wei Anzhi
Published: May 2020

Chinese pepper, referring to Zanthoxylum bungeanum Maxim. and Zanthoxylum armatum DC. species, is an important spice crop that has long attracted people’s interest due to its extensive application in Asian cuisine to improve taste. Numerous cultivars have been developed during the long history of domestication and cultivation. However, little to no information is available on the genetic diversity and evolutionary relationships of Chinese pepper cultivars and their historical diversification has not been clarified. Herein, we sequenced two nrDNA non-coding region markers, the external transcribed spacer (ETS) and the internal transcribed spacer 2 (ITS2), to assess genetic diversity and phylogenetic relationships among 39 cultivated and wild populations of Chinese pepper from eight provinces and to address the question of ancient demographic trends which were probably influenced by changing climate during evolutionary history. In total, 31 haplotypes were identified based on 101 polymorphism sites. Our results revealed relatively high level of genetic variation despite long-term cultivation of this crop. AMOVA revealed that genetic variation existed predominantly within provinces rather than among provinces. The genetic structure result based on haplotype network analysis largely reflected historical records, which suggested a Gansu origin for Chinese pepper and an ancient west-to-east spread of Chinese pepper circulating in China. We also provided evidence that changing Pleistocene climates had shaped the demographic trends of Chinese pepper. Taken together, our findings not only suggest that Chinese pepper is a dynamic genetic system that responds to evolutionary forces, but it also provides a fundamental genetic profile for the conservation and responsible exploitation of the extant germplasm of Chinese pepper and for improving the genetic basis for breeding the cultivars.
Homogenization of Temperate Mixed Deciduous Forests in Białowieża Forest: Similar Communities Are Becoming More Similar
Authors: Cholewińska Olga , Adamowski Wojciech , Jaroszewicz Bogdan
Published: May 2020

Many studies show the significant impact of direct and indirect human activity on the functioning of terrestrial ecosystems, including forests. The increase in the number of invasive species, changes caused by climate change, or eutrophication of habitats resulting from air pollution can irrevocably affect biodiversity, species composition, or species interactions. Many of these effects cannot be seen in commercial forests due to the significant impact of direct human use of the forest and the high degree of transformation of forest ecosystems. In this work, we ask: how have forest communities changed over the past 70 years? What was the reason for these changes? To answer the above questions, we conducted research on repeated observations in the core area of the Białowieża National Park, which is characterized by one of the highest degrees of naturalness in Europe, where ecological processes have occurred without direct human intervention since the last glaciation. Studies have shown directional changes in species composition and biotic homogenization of three forest communities. Directional changes were found to be associated with both eutrophication of habitats as well as with changes in humidity and temperature. However, the observed changes in species composition were opposite to the hypotheses based on the observed global change. In contrast, changes in the species composition of the stand and the ability to shade and buffer the temperature and humidity under the canopy caused changes in the species composition of forest communities. In the mixed deciduous forest, homogenization occurred along with the simultaneous change of species composition of forest communities. This was caused by an increase in fertility caused by increased nitrogen deposition and changes in environmental conditions prevailing under the canopy of trees, which, however, were caused by changes in the species composition of the stand.
Genetic Diversity and Population Structure of Llamas (Lama glama) from the Camelid Germplasm Bank—Quimsachata
Authors: Paredes Gabriela F. , Yalta-Macedo Claudia E. , Gutierrez Gustavo A. , Veli-Rivera Eudosio A.
Published: May 2020

Llamas (Lama glama) are invaluable resources of Peru. Despite their importance, their population is decreasing. The Camelid Germplasm Bank—Quimsachata was created as a guardian of this South American camelid (SAC) species and established a bank of llamas from their two types, Ch’aku and Q’ara. However, these populations need to present high genetic diversity to be considered suitable conservation stocks. Thus, in the present study, 13 microsatellites specific for the SAC were used to assess the current genetic variability and differentiation of the llama population from the Bank. The global population showed high genetic diversity with a total of 157 different alleles, with an average of 12.08 alleles per microsatellite, an expected and observed heterozygosity of 0.758 and 0.707, respectively, and an average polymorphic information content (PIC) of 0.723. Although considered as two different breeds and managed separately, the genetic differentiation between Ch’aku and Q’ara was low (FST = 0.01). Accordingly, the gene flow value was high (Nm = 30.5). Overall, our results indicate the existence of high genetic variation among individuals, and thus, this llama population could be considered a suitable genetic stock for their conservation and for sustainability programs. Additionally, the 13 microsatellites can be used to study other Peruvian llama populations and monitor the genetic variability of llamas from the Camelid Germplasm Bank—Quimsachata.
Tsunami Damage Detection with Remote Sensing: A Review
Authors: Koshimura Shunichi , Moya Luis , Mas Erick , Bai Yanbing
Published: May 2020

Tsunamis are rare events compared with the other natural disasters, but once it happens, it can be extremely devastating to the coastal communities. Extensive inland penetration of tsunamis may cause the difficulties of understanding its impact in the aftermath of its generation. Therefore the social needs to technologies of detecting the wide impact of great tsunamis have been increased. Recent advances of remote sensing and technologies of image analysis meet the above needs and lead to more rapid and efficient understanding of tsunami affected areas. This paper provides a review of how remote sensing methods have developed to contribute to post-tsunami disaster response. The evaluations in the performances of the remote sensing methods are discussed according to the needs of tsunami disaster response with future perspective.
An Endowment Effect Study in the European Union Emission Trading Market based on Trading Price and Price Fluctuation
Authors: Wang Jiqiang , Gu Fu , Liu Yingpeng , Fan Ying , Guo Jianfeng
Published: May 2020

This paper pioneers to investigate the endowment effect in the European Union mission Trading Scheme (EU ETS) as well as the impacts of trading experience and compliance pressure on the endowment effect. This study is based on the complete transaction records of the market. In the data set, the records of two consecutive reverse transactions from a same emitting company are selected. The lowest price that the buyer is willing to pay (WTP) and the maximum price the seller is willing to accept (WTA) are evaluated by excluding their risk cost that is used to avoid short-term fluctuations in the price. By distinguishing the difference between WTA and WTP, and long-term fluctuations in the prices during the two transactions, the trader’s endowment effect can be quantitively assessed. The results show that the degree of endowment effect of traders follows the trading experience. In addition, since the EU ETS is a cap-and-trade market, the traders face different levels of compliance pressure; when the pressure of the emission companies increases, the degree of endowment effect will also decrease.
Spatio-Temporal Resource Mapping for Intensive Care Units at Regional Level for COVID-19 Emergency in Italy
Authors: Guzzi Pietro Hiram , Tradigo Giuseppe , Veltri Pierangelo
Published: May 2020

COVID-19 is a worldwide emergency since it has rapidly spread from China to almost all the countries worldwide. Italy has been one of the most affected countries after China. North Italian regions, such as Lombardia and Veneto, had an abnormally large number of cases. COVID-19 patients management requires availability of sufficiently large number of Intensive Care Units (ICUs) beds. Resources shortening is a critical issue when the number of COVID-19 severe cases are higher than the available resources. This is also the case at a regional scale. We analysed Italian data at regional level with the aim to: (i) support health and government decision-makers in gathering rapid and efficient decisions on increasing health structures capacities (in terms of ICU slots) and (ii) define a geographic model to plan emergency and future COVID-19 patients management using reallocating them among health structures. Finally, we retain that the here proposed model can be also used in other countries.
Antecedents of Psychological Well-Being among Swedish Audit Firm Employees
Authors: Broberg Pernilla , Tagesson Torbjörn , Uman Timur
Published: May 2020

The attractiveness of audit firms as employers appears to have decreased in recent years and the audit profession is currently experiencing high employee turnover. A shortage of personnel increases the risk of long-term stress and illness. This paper therefore proposes audit firm employees’ well-being as an important research topic and explores the antecedents of well-being of Swedish audit firm employees in comparison with those of other business professionals. Based on a nationwide survey of members of the Swedish association of business professionals, with a focus on psychological well-being (measured through General Health Questionnaire-12 (GHQ-12)), the study shows that the psychological well-being of the professionals in this study generally aligns with the results from similar studies in a Swedish context. However, the findings indicate that audit industry respondents have the lowest psychological well-being and that employer change, job satisfaction, and life satisfaction were the strongest antecedents of their psychological well-being.
An Application of Metabolic Syndrome Severity Scores in the Lifestyle Risk Assessment of Taiwanese Adults
Authors: Lin Chih-Ming
Published: May 2020

A metabolic syndrome (MS) diagnosis was made when the criteria for three or more of five MS components were met. Due to some limitations in the traditional MS criteria, however, different health care societies have sought to develop applicable MS scoring systems instead. Continuous MS scores can be of meaningful value in the prevention, diagnosis, and treatment of MS at different life stages. Relatedly, this study used a database for 27,748 subjects aged 20 to 64 years who received health checks at a health screening institution in Taiwan from 2010 to 2015 to a similar end. Five components of MS (waist circumference, fasting plasma glucose, blood pressure, fasting triglycerides, and high-density lipoprotein) were used to formulate an MS severity score in different gender and age stratums, which was then used to evaluate the risks of various lifestyle habits. Those estimates were then compared with the results for traditional MS diagnosis. The MS severity scores for some behaviors relating to smoking, drinking, physical activity, and sweetened beverage consumption were found to have changed from 0.03 to 0.2; however, a logistic regression analysis with dichotomous diagnosis did not indicate significant links between these behaviors and MS. The models established by the MS severity scores can identify the risk factors for MS in a more sensitive manner than the traditional MS diagnosis can, especially with respect to specific lifestyle habits. MS severity score can serve as an indicator to explore the potential risk factors for subclinical conditions in the early stages of MS.
Escherichia coli Antimicrobial Susceptibility Reduction amongst HIV-Infected Individuals at the University Teaching Hospital, Lusaka, Zambia
Authors: Chabala Freeman , Madubasi Mutinta , Mutengo Mable Mwale , Banda Njeleka , Yamba Kaunda , Kaonga Patrick
Published: May 2020

Increased antimicrobial resistance among Human Immunodeficiency Virus (HIV)-infected individuals to commonly used antibiotics in the treatment of gastroenteritis is a public health concern, especially in resource-limited settings. We set out to compare the antimicrobial susceptibility pattern of Escherichia coli (E. coli) isolates from HIV-infected and HIV-uninfected individuals at a tertiary hospital in Lusaka, Zambia. An analytical cross-sectional study was conducted at the University Teaching Hospital from May 2019 to August 2019. Stool samples were screened, and 79 HIV-infected individuals matched by age and sex with 84 HIV-uninfected individuals that presented with E. coli associated gastroenteritis were studied. Demographics were collected from the Laboratory Information System (LIS) and stool samples were collected in a sterile leak-proof container. Samples were cultured and only those where E. coli was isolated were included in the study and tested for antimicrobial susceptibility by the Kirby–Bauer disk diffusion technique. HIV-positive individuals were 3 times (adjusted odds ratio (AOR) = 3.17; 95% CI (1.51, 6.66); p < 0.001) more likely to be resistant to quinolones compared with their HIV-negative counterparts. Similarly, HIV-positive individuals were almost 4 times (AOR = 3.97, 95% CI (1.37, 11.46); p = 0.011) more likely to have multidrug-resistant E. coli compared with those who were HIV-negative. HIV infection was associated with reduced E. coli susceptibility to commonly used antibiotics, and most cases showed resistance.
The Predictive Capacity of Air Travel Patterns during the Global Spread of the COVID-19 Pandemic: Risk, Uncertainty and Randomness
Authors: Christidis Panayotis , Christodoulou Aris
Published: May 2020

Air travel has a decisive role in the spread of infectious diseases at the global level. We present a methodology applied during the early stages of the COVID-19 pandemic that uses detailed aviation data at the final destination level in order to measure the risk of the disease spreading outside China. The approach proved to be successful in terms of identifying countries with a high risk of infected travellers and as a tool to monitor the evolution of the pandemic in different countries. The high number of undetected or asymptomatic cases of COVID-19, however, limits the capacity of the approach to model the full dynamics. As a result, the risk for countries with a low number of passengers from Hubei province appeared as low. Globalization and international aviation connectivity allow travel times that are much shorter than the incubation period of infectious diseases, a fact that raises the question of how to react in a potential new pandemic.
Initiation and Single Dispensing in Cardiovascular and Insulin Medications: Prevalence and Explanatory Factors
Authors: Vilaplana-Carnerero Carles , Aznar-Lou Ignacio , Peñarrubia-María María Teresa , Serrano-Blanco Antoni , Fernández-Vergel Rita , Petitbò-Antúnez Dolors , Gil-Girbau Montserrat , March-Pujol Marian , Mendive Juan Manuel , Sánchez-Viñas Alba , Carbonell-Duacastella Cristina , Rubio-Valera Maria
Published: May 2020

Background: Adherence problems have negative effects on health, but there is little information on the magnitude of non-initiation and single dispensing. Objective: The aim of this study was to estimate the prevalence of non-initiation and single dispensation and identify associated predictive factors for the main treatments prescribed in Primary Care (PC) for cardiovascular disease (CVD) and diabetes. Methods: Cohort study with real-world data. Patients who received a first prescription (2013–2014) for insulins, platelet aggregation inhibitors, angiotensin-converting enzyme inhibitors (ACEI) or statins in Catalan PC were included. The prevalence of non-initiation and single dispensation was calculated. Factors that explained these behaviours were explored. Results: At three months, between 5.7% (ACEI) and 9.1% (antiplatelets) of patients did not initiate their treatment and between 10.6% (statins) and 18.4% (ACEI) filled a single prescription. Body mass index, previous CVD, place of origin and having a substitute prescriber, among others, influenced the risk of non-initiation and single dispensation. Conclusions: The prevalence of non-initiation and single dispensation of CVD medications and insulin prescribed in PC in is high. Patient and health-system factors, such as place of origin and type of prescriber, should be taken into consideration when prescribing new medications for CVD and diabetes.
Development of a Method to Locate Deserts and Food Swamps Following the Experience of a Region in Quebec, Canada
Authors: Robitaille Éric , Paquette Marie-Claude
Published: May 2020

Unhealthy eating and food insecurity are recognized risk factors for chronic diseases. Collective and environmental factors, such as geographic access to food condition food choices. The objective of this study was to map food deserts and food swamps in Gaspesie, a region of Quebec (Canada), using geographical information systems (GIS) and field validation. Eleven sectors (5 rural and 6 urban) where 5% of the Gaspesie population lives were considered food deserts. Eight sectors (all rural) constituting 4.5% of the population were considered food swamps. Nearly 88% (3/8) of food swamps were located in disadvantaged and very disadvantaged areas. The Gaspesie region is already actively involved in changing environments to make them conducive to healthy eating for all. The mapping of food deserts can support intersectoral collaboration on food security. Food swamp mapping will make it possible to more accurately characterize the existing food environment in the region. Both indicators will be useful in raising awareness and mobilizing partners for a comprehensive strategy to improve the food environment that is not only based on the food desert indicator alone but also takes into account the presence of food swamps.
Self-Reported Prevalence of Allergies in the USA and Impact on Skin—An Epidemiological Study on a Representative Sample of American Adults
Authors: Seité Sophie , Kuo Alyce Mei-Shiuan , Taieb Charles , Strugar Tamara Lazić , Lio Peter
Published: May 2020

Background: The rising prevalence of allergies can substantially impact the skin, which is one of the largest targets for allergic and immunologic responses. Objective: Here, we describe the results of an online survey assessing self-reported allergy prevalence in Americans, outline the populations who report allergies, and characterize the skin conditions associated with allergy. Methods: An online survey was conducted in the USA of 2008 adults as a representative sample of the general American population. Results: 41.7% of American adults (mean age 44.7 ± 15.3 years old) reported having allergies. Reported allergies included respiratory allergies (45.2%), skin allergies (41.4) and food allergies (33.9%). 47.7% of those who reported allergies also reported experiencing associated skin reactions. In addition, those who reported allergies were 2 to 4.5 times more likely to report a cutaneous skin disease, 7 times more likely to report sensitive skin, and twice as likely to report experiencing skin reactions when using skincare products compared to those who did not report allergies. Conclusions: It is estimated that over 100 million American adults have allergies. These results will help raise awareness about the burden of allergies and the need to develop solutions to mitigate their impact on health.
Decision-Making Process in Female Genital Mutilation: A Systematic Review
Authors: Alradie-Mohamed Angi , Kabir Russell , Arafat S.M. Yasir
Published: May 2020

Female genital mutilation/cutting “FGM/C” is a deep-rooted damaging practice. Despite the growing efforts to end this practice, the current trends of its decline are not enough to overcome the population’s underlying growth. The aim of this research is to investigate the FGM/C household decision-making process and identify the main household decision-makers. A review of peer-reviewed articles was conducted by searching PubMed, JSTOR, Ovid MEDLINE, Ovid EMBASE, EBSCO, and CINAHL Plus via systematic search using keywords. The found publications were screen using inclusion and exclusion criteria in line with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. After critical appraisal, seventeen articles were included in this review. The data extracted from the articles regarding FGM/C household-decision making process and decision-makers were analyzed using narrative analysis. FGM/C decision-making process varies from a region to another; however, it generally involves more than one individual, and each one has different power over the decision. Fathers, mothers, and grandmothers are the main decision-makers. It was shown from this review that opening the dialogue regarding FGM/C between sexes may lead to a productive decision-making process. The participation of fathers in the decision-making may free the mothers from the social-pressure and responsibility of carrying on traditions and create a more favorable environment to stop FGM/C practice.
Disparities in the Use of General Somatic Care among Individuals Treated for Severe Mental Disorders and the General Population in France
Authors: Gandré Coralie , Coldefy Magali
Published: May 2020

Individuals with severe mental illnesses (SMI) face a striking excess and premature mortality which has been demonstrated in several national contexts. This phenomenon, which constitutes a red-flag indicator of public health inequities, can be hypothesized to result from healthcare access issues which have been insufficiently documented so far. In this context, our objective was to explore patterns of general somatic healthcare use of individuals treated for SMI in comparison to those of the general population in France using national health administrative data and a matched case-control study. Differences in the use of general and specific somatic preventive care services, primary care, routine specialized somatic care and admissions to non-psychiatric hospital departments for somatic causes were described between cases and controls after adjustment on differing clinical needs, socio-economic status, and living environment. Our results show a lower use of general preventive care services and of routine specialized somatic care in the SMI population, despite more frequent comorbidities, and a higher occurrence of avoidable hospitalizations, despite higher contacts with primary care physicians. These findings suggest that the health system fails to address the specific needs of this vulnerable population and support the development of measures aimed at reducing this gap.
The Bisphenol A Induced Oxidative Stress in Non-Alcoholic Fatty Liver Disease Male Patients: A Clinical Strategy to Antagonize the Progression of the Disease
Authors: Federico Alessandro , Dallio Marcello , Gravina Antonietta Gerarda , Diano Nadia , Errico Sonia , Masarone Mario , Romeo Mario , Tuccillo Concetta , Stiuso Paola , Morisco Filomena , Persico Marcello , Loguercio Carmelina
Published: May 2020

Introduction: Bisphenol A (BPA) exposure has been correlated to non-alcoholic fatty liver disease (NAFLD) development and progression. We investigated, in a clinical model, the effects of the administration of 303 mg of silybin phospholipids complex, 10 μg of vitamin D, and 15 mg of vitamin E (RealSIL, 100D, IBI-Lorenzini, Aprilia, Italy) in male NAFLD patients exposed to BPA on metabolic, hormonal, and oxidative stress-related parameters. Methods: We enrolled 32 male patients with histologic diagnosis of NAFLD and treated them with Realsil 100D twice a day for six months. We performed at baseline clinical, biochemical, and food consumption assessments as well as the evaluation of physical exercise, thiobarbituric acid reactive substances (TBARS), plasmatic and urinary BPA and estrogen levels. The results obtained were compared with those of healthy control subjects and, in the NAFLD group, between baseline and the end of treatment. Results: A direct proportionality between TBARS levels and BPA exposure was shown (p < 0.0001). The therapy determined a reduction of TBARS levels (p = 0.011), an improvement of alanine aminotransferase, aspartate aminotransferase, insulinemia, homeostatic model assessment insulin resistance, C reactive protein, tumor necrosis factor alpha (p < 0.05), an increase of conjugated BPA urine amount, and a reduction of its free form (p < 0.0001; p = 0.0002). Moreover, the therapy caused an increase of plasmatic levels of the native form of estrogens (p = 0.03). Conclusions: We highlighted the potential role of BPA in estrogen oxidation and oxidative stress in NAFLD patients. The use of Realsil 100D could contribute to fast BPA detoxification and to improve cellular antioxidant power, defending the integrity of biological estrogen-dependent pathways.
Identifying Research Trends and Gaps in the Context of COVID-19
Authors: Zhang Hongyue , Shaw Rajib
Published: May 2020

The COVID-19 pandemic has affected the world in different ways. Not only are people’s lives and livelihoods affected, but the virus has also affected people’s lifestyles. In the research sector, there have been significant changes, and new research is coming very strongly in the related fields of virology and epidemiology. Similar trends were observed after the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) episodes of 2003 and 2012, respectively. Analyzing 20 years of published scientific papers, this article points out the highlights of coronavirus-related research. Significant progress is observed in the past research related to virology, epidemiology, infectious diseases among others. However, in research linked to public health, its governance, technology, and risk communication there seem to be gap areas. Although the World Health Organization (WHO) global research road map has identified social science-related research as a priority area, more focus needs to be given in the upcoming days for multi, cross and trans-disciplinary research related to public health and disaster risk reduction.
Research on the Relationships between Psychological Problems and School Bullying and Non-Suicidal Self-Injury among Rural Primary and Middle School Students in Developing Areas of China
Authors: Li Xuyang , Chen Feiyu , Lin Yixiang , Jia Zhihui , Tucker Winter , He Jiangyan , Cui Lanyue , Yuan Zhaokang
Published: May 2020

(1) Purpose: To analyze the role of psychological problems in connection with school bullying and non-suicidal self-injury (NSSI) among rural primary and middle school students in developing areas of China. (2) Methods: A multi-stage, stratified, cluster random sampling method was used to select 2284 rural primary and middle school students in Jiangxi Province for study. Questionnaires regarding the health risk behaviors of children in developing areas were left behind at primary and middle schools, and they were later collected and analyzed by using the mental health diagnostic monitoring scale for Chinese primary and middle school students. Pearson correlation, logistic regression, and bootstrap tests were conducted to analyze the association between psychological problems, school bullying, and NSSI. (3) Results: The incidence of NSSI in rural primary and middle school students in Jiangxi Province was 14.84%. Compared with other children with behavioral problems, those who had experienced school bullying and had mild/severe psychological problems were more likely to have engaged in NSSI behaviors (p < 0.001). Psychological problems have a mediating effect between school bullying and NSSI, which accounted for 12.96% of the total effect. (4) Conclusion: Psychological problems are likely an effect modifier in the connection between school bullying and NSSI behaviors. Therefore, effectively targeting psychological problems in rural primary and middle school students in Jiangxi Province may help prevent and control NSSI behaviors in students who have experienced school bullying.
Influence of Academic Performance, Level of Play, Sports Success, and Position of Play on the Motivation of the Young Football Player
Authors: Ureña-Lopera Christian , Morente-Oria Honorato , Chinchilla-Minguet José Luis , Castillo-Rodríguez Alfonso
Published: May 2020

Background: Motivation in athletes is a state that fluctuates due to multiple factors that can, in turn, negatively or positively influence sports performance. Objectives: The aim of this study was twofold, being, on the one hand, to analyze the motivation of soccer players of developmental age in two different contexts (training time (baseline) and the precompetitive time) depending on the category, sports success and playing position, and, on the other hand, to find relations of the motivation dimensions with the academic performance and physical characteristics of the soccer players. Methods: One hundred and forty-one under 16 (U16) soccer players were selected (age: 14.7 ± 0.5; height: 170.4 ± 7.2 cm; weight: 61.6 ± 10.0 kg). Data on academic performance, physical and socio-demographic characteristics were recorded, and in two differentiated moments, the motivation dimensions, both in training and in competition. Results: The results showed that the general motivation decreases with the competition, and in particular, the intrinsic motivation, where the precompetitive evaluation is lower than the basal, in both categories (p < 0.05). In addition, demotivation is explained by 10.2%, 19.8%, and 23.9% by fat mass, by academic performance, and by category, respectively; and the extrinsic motivation of external regulation is explained in 26.0% by the academic performance factor (p < 0.01). Conclusions: U16 soccer players show lower levels of motivation at moments prior to the sports competition, and these dimensions of motivation are explained by the category, academic performance, and fat mass.
Worldwide Research Trends on Medicinal Plants
Authors: Salmerón-Manzano Esther , Garrido-Cardenas Jose Antonio , Manzano-Agugliaro Francisco
Published: May 2020

The use of medicinal plants has been done since ancient times and may even be considered the origin of modern medicine. Compounds of plant origin have been and still are an important source of compounds for drugs. In this study a bibliometric study of all the works indexed in the Scopus database until 2019 has been carried out, analyzing more than 100,000 publications. On the one hand, the main countries, institutions and authors researching this topic have been identified, as well as their evolution over time. On the other hand, the links between the authors, the countries and the topics under research have been analyzed through the detection of communities. The last two periods, from 2009 to 2014 and from 2015 to 2019, have been examined in terms of research topics. It has been observed that the areas of study or clusters have been reduced, those of the last period being those engaged in unclassified drug, traditional medicine, cancer, in vivo study—antidiabetic activity, and animals—anti-inflammatory activity. In summary, it has been observed that the trend in global research is focused more on the search for new medicines or active compounds rather than on the cultivation or domestication of plant species with this demonstrated potential.
Occupational Health among Swedish Occupational Therapists: A Cross-Sectional Study
Authors: Lexén Annika , Kåhlin Ida , Erlandsson Lena-Karin , Håkansson Carita
Published: May 2020

The Swedish public sector is facing great challenges in recruiting and retaining healthcare professionals, due to increasing sick leave numbers. The aim of this study was to describe Swedish occupational therapists’ occupational health in terms of risk factors in the social and organizational work environment, occupational balance, and work-related mental health problems. A web survey was emailed to all working members of the Swedish Association of Occupational Therapists (n = 7600) and 3658 answered the survey. The web survey included questions on sociodemographic characteristics, social and organizational environment, occupational balance, and work-related health. The occupational therapists in general rated their workload as high, which was described as leading to increased stress, difficulties doing a good job, and increased job turnover. They also reported having difficulties maintaining occupational balance. Almost a fifth reported having symptoms related to mild incipient exhaustion or a pronounced exhaustion disorder. Almost 60 percent reported having, during the last year, seriously considered seeking new employment as an occupational therapist and 35 percent had seriously intended to leave their profession. In conclusion, there is an urgent need to improve the work situation of occupational therapists. If not, increases in mental health problems, sick leave and job turnover rates may seriously jeopardize the welfare system by eroding healthcare.
Corrrection: The Effect of Innovation-Driven Strategy on Green Economic Development in China—An Empirical Study of Smart Cities. Int. J. Environ. Res. Public Health 2019, 16(9), 1520
Authors: Cao Wenbin , Zhang Ying , Qian Peng
Published: May 2020

The authors wish to add the following correction to their paper published in the International Journal of Environmental Research and Public Health [...]