bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Biaya Pembangunan Site Facilities Proyek Revetment dan Retaining Wall Dermaga Benoa
Authors: Wahyudi I Gede Bambang , Parthama Kadek Adi , Sujahtra I Wayan , Yuni Ni Kadek Sri Ebtha , Yuliana Ni Putu Indah
Published: September 2023

Process of a construction project is knowing how much a building will cost. Like the main building, the project site facilities also require costs that are not included in the direct financing of the project. The goal is to provide detailed information on the cost of building site facilities and to serve as reference material for the preparation of RAB site facilities. Implemented in the Revetment dan Retaining Wall Harbor Benoa project, the survey it was found that this project had built a number of temporary facilities but did not clearly detail the cost requirements. The research used descriptive quantitative methods and data collection in the form of surveys, observations and interviews. Survey to measure temporary buildings at the project site and find unit prices of tools, materials and labor at shops or foremen around the project area. Observation observes the layout of the building which will be outlined in the field layout drawing.An interview with the project manager was conducted to find out the total cost of the project and the costs incurred by the contractor for construction. Data analysis using Microsoft Excel by entering all components to be analyzed. Based on the results, it is concluded that the site facilities that are built are the contractor's office, health room, motorcycle and car parking, workers' toilets, directors' and consultants' offices, LAB rooms, cement and plywood warehouses, mechanical warehouses, security and K3 posts, workers' beds, trash bins, and water reservoirs. The comparison of site facilities cost to contract is 0.253%.
Analisis Penurunan Daya Dukung Tiang Tunggal pada Tanah yang Berpotensi Mengalami Likuifaksi di Kota Denpasar, Bali
Authors: Pramana I Made Wahyu , Arya I Wayan , Wiraga I Wayan , Dwipa RS IGAG Surya Negara
Published: September 2023

In Indonesia, earthquakes occur very frequently. As a result of the earthquake, the safety of building structures against earthquakes really needs to be taken into account in the analysis of calculating the factor of safety. Apart from the effect of the earthquake on the superstructure, the effect of the earthquake on the substructure must also be considered. One of the substructure failures that can occur in the substructure due to an earthquake is a soil liquefaction where the soil experiences a loss/decrease in the bearing capacity of the soil as a result of the earthquake. This study used a quantitative method by conducting soil investigations and taking soil samples from the field. The results of the soil investigation will be used in calculating the potential for liquefaction of the soil layers and the axial bearing capacity of single pile foundations before and during liquefaction. At the study site, the dominant soil is loose sand with a high ground water table. The soil has the potential to experience liquefaction from a depth of 1.5 m to 13 m. This study modeled 2 pile models where both of them experienced a decrease in the axial pile bearing capacity respectively: 93% and 79%.
PENERAPAN MODEL PEMBELAJARAN PROBLEM BASED LEARNING (PBL) UNTUK MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR MATEMATIKA PESERTA DIDIK KELAS VIII SMPN 04 KOTA BENGKULU
Authors: Putri Cindy Samya , Lensy Nurul Astuty
Published: September 2023

Penelitian ini bertujuan untuk memperbaiki proses pembelajaran dan meningkatkan hasil belajar matematika siswa kelas VIII SMPN 04 Kota Bengkulu pada materi Pola Bilangan dan Koordinat Kartesius tahun pelajaran 2022/2023, melalui penerapan Model Pembelajaran Problem Based Learning (PBL). Subjek dalam penelitian ini adalah siswa kelas VIII.1 SMPN 04 Kota Bengkulu Siswa yang berjumlah 32 orang peserta didik. Penelitian ini dilaksanakan pada tanggal 18 Juli 2022 sampai dengan 10 Agustus 2022. Bentuk penelitian yang dilakukan adalah Penelitian Tindakan Kelas (PTK) dengan dua siklus. Instrumen penelitian dalam penelitian ini adalah perangkat pembelajaran yang terdiri dari Silabus, Rencana Pelaksanaan Pembelajaran (RPP), Lembar Kerja Peserta Didik (LKPD). Instrumen pengumpulan data yang digunakan pada penelitian ini adalah lembar pengamatan dan tes hasil belajar. Teknik yang digunakan untuk mengumpulkan data dalam penelitian ini adalah teknik non-tes dan teknik tes. Teknik analisis data yang digunakan adalah analisis data tentang aktivitas siswa (Kualitatif), analisis data hasil belajar (Kuantitatif), dan analisis keberhasilan tindakan. Hasil penelitian menunjukkan bahwa adanya penignkatan hasil belajar pada siklus I dibandingkn sebelum dilakukannya tindakan. Peningkatan juga terjadi pada hasil belajar Siklus II dibandingkan dengan Siklus I. Pada Siklus I skor aktivitas belajar hanya sebesar 22,38% dengan kategori cukup, namun pada Siklus II skor aktivitas sudah pada kategori aktif dengan 27,3%. Hasil belajar dari Siklus I ke Siklus II juga mengalami peningkatan dari ketuntasan 53,12% menjadi 81,25%. Berdasarkan hasil penelitian ini maka dapat disimpulkan bahwa penerapan model Problem Based Learning (PBL) dapat meningkatkan aktivitas dan hasil belajar matematika peserta didik kelas VIII SMPN 04 Kota Bengkulu tahun ajaran 2022/2023 khususnya pada materi Pola Bilangan dan Koordinat Kartesius.
Türkiye’de Liberal İlahiyat ve Kur’an’ın Akademik Bir Metin Olarak Yükselişi
Authors: DURAN Asim
Published: September 2023

Bu makale, ilahiyatın bilim olarak tanımlanmasıyla Kur’an’ın bilhassa üniversite kürsülerinde akademik bir metin olarak ele alınışını konu edinmektedir. Yazının amacı, akademik Kur’an şeklinde tanımlayabileceğimiz bir kavramın üretilmesine olanak sağlayan kurumsal ve entelektüel bağlamın temel hususiyetlerini tartışmak ve bunların yeni Kur’an araştırmalarına tesirlerini göstermektir. Konunun önemi, bu kavramın, Türkiye’de Kur’an’ın yorumu konusunda kurumsal değişimin (medreseden üniversiteye) somut bir örneğini ifade etmesinden kaynaklanmaktadır. Aynı zamanda o, Kur’an üzerine söz söyleme salahiyetini elinde bulunduran zümrenin değişimine (molladan profesöre) dair önemli ipuçlarını barındırır. Bu yüzden, böyle bir sorunun çerçevesinin çizilmesi, zuhur eden sosyolojinin portresinin çıkarılması ve sürecin tartışılması, bugüne kadar birikerek gelen literatüre katkı namına değerlendirilebilir. Araştırma boyunca konu, ilahiyat ve kimi zaman dinler tarihi sahasında kalarak kurumsal yapı (medrese-üniversite) ile sınıfsal zümre (molla/hoca-profesör) gibi semboller açısından yapılacak değerlendirmelerle ve Batı ilahiyatında benzer sürece tekabül eden bazı kıyaslamalarla sınırlandırılmıştır. Esasen, akademik Kur’an kavramı da araştırmanın bu sınırlılığını büyük oranda karşılaması dolayısıyla tercih edilmiştir.
PERSPEKSTIF AJARAN ISLAM DALAM PRAKTEK PENGHINDARAN PAJAK
Authors: Moeljono Moeljono , Holle Mohammad H
Published: September 2023

Abstract:This article emphasizes the `perspective` of Islam, towards the practice of tax avoidance. Tax is an obligation for Muslims to the state. However, the practice of tax avoidance is increasingly widespread, even by corporations. So that the state is disadvantaged, because state revenue is reduced from the tax sector which is used for the national development process.This article uses a literature study approach, and the data used is secondary data. The results of this study are that with the practice of tax avoidance, the impacts are, 1. Reduced National Income. 2. Detriment to shareholders, because the returns they receive are smaller than what they should be getting, 3. Hoarding their wealth in certain groups.The practice of tax avoidance, legally does not commit a violation. However, the practice of tax avoidance has done injustice to society and the state. So their norm has been violated. During the punishment of the Prophet Muhammad, those who did not want to pay zakat were punished in the world and the hereafter, while during the time of Caliph Abu Bakar and Caliph Umar Bin Khattab they fought against those who did not pay zakat because they betrayed religion and state.Key Word : Tax Avoidance, Islam, Income, National, Harmful  AbstrakArtikel ini menekankan pada `perspekstif` Islam, terhadap praktek penghindaran pajak. Pajak merupakan kewajiban bagi umat Islam kepada negara. Namun, praktik penghindaran pajak semakin marak, bahkan dilakukan oleh korporasi. Sehingga negara dirugikan, karena penerimaan negara berkurang dari sektor pajak yang digunakan untuk proses pembangunan nasional.Artikel ini menggunakan pendekatan studi kepustakaan, dan data yang digunakan data sekunder. Hasil dari kajian ini adalah dengan adanya praktek penghindaran pajak maka dampak yang ditimbulkan adalah, 1. Berkurangnya Pendapatan Nasional. 2. Merugikan pemegang saham, karena return yang diterimanya lebih kecil dari yang seharusnya didapat, 3. Menimbun kekayaannya pada kelompok tertentu.Praktek penghindaran pajak, secara hukum tidak melakukan pelanggaran. Namun, praktek penghindaran pajak telah melakukan ketidakadilan terhadap masyarakat dan negara. Jadi norma mereka telah melakukan pelanggaran. Pada masa hukuman Rasulullah SAW bagi orang yang tidak mau membayar zakat mendapat hukuman dunia dan akherat, sedangkan pada masa Khalifah Abu Bakar dan Khalifah Umar Bin Khattab mereka memerangi bagi yang tidak membayar zakat karena mengkhianati agama dan negara.Kata Kunci: Penghindaran Pajak, Islam, Pendapatan, Nasional, Merugikan
Modulation of ionizing radiation-induced apoptosis and cell cycle arrest by all-trans retinoic acid in promyelocytic leukemia cells (HL-60).
Authors: Mareková M , Vávrová J , Vokurková D , Psutka J
Published: September 2023

Acute promyelocytic leukemia is characterized by a block of myeloid differentiation. The incubation of cells with 1 μmol/l all-trans retinoic acid (ATRA) for 72 h induced differentiation of HL-60 cells and increased the number of CD11b positive cells. Morphological and functional changes were accompanied by a loss of proliferative capacity. Differentiation caused by preincubation of leukemic cells HL-60 with ATRA is accompanied by loss of clonogenicity (control cells: 870 colonies/103 cells, cells preincubated with ATRA: 150 colonies/103 cells). D0 for undifferentiated cells was 2.35 Gy, for ATRA differentiated cells 2.46 Gy. Statistical comparison of clonogenity curves indicated that in the whole range 0.5-10 Gy the curves are not significantly different, however, in the range 0.5-3 Gy ATRA differentiated cells were significantly more radioresistant than non-differentiated cells. When HL-60 cells preincubated with 1 μmol/l ATRA were irradiated by a sublethal dose of 6 Gy, more marked increase of apoptotic cells number was observed 24 h after irradiation and the surviving cells were mainly in the G1 phase of the cell cycle, while only irradiated cells were accumulated in G2 phase. Our results imply that preincubation of cells with ATRA accelerates apoptosis occurrence (24 h) after irradiation by high sublethal dose of 6 Gy. Forty-eight hours after 6 Gy irradiation, late apoptotic cells were found in the group of ATRA pretreated cells, as determined by APO2.7 positivity. This test showed an increased effect (considering cell death induction) in comparison to ATRA or irradiation itself.
Remodeling of the rat saphenous vein network in response to long-term gravitational load.
Authors: Lóránt M , Nádasy GL , Raffai G , Monos E
Published: September 2023

Our main objective was to test whether chronic orthostatic body position induces network changes in the saphenous vein superficial tributary system of the rat. Fourteen male Sprague-Dawley rats were kept in tilted tube cages (45º head-up position) for two weeks to induce chronic gravitational load to their leg veins. Ten animals housed in normal cages and four animals kept in horizontally positioned tube cages served as controls. The whole superficial network of the left saphenous vein was microprepared surgically under anesthesia, superfused with saline and observed under a videomicroscope, while normal flow and pressure were maintained in the lumen. Branching angles, lengths of venous segments and their diameters were measured offline from digitized images using special image-analyzing software. Several branching angles at the popliteal confluence were significantly reduced by 12.5-15.8 %. The in vivo diameter of the main branch (936±34 vs. 805±44 µm) and of one of the popliteal tributaries (776±38 vs. 635±36 µm) increased (p<0.05), comparing vessels from tilted animals with those from normal controls. Maintaining the animals in horizontal tube cages did not induce the above alterations. The increased diameters and reduced branching angles of the saphenous vein network observed are adaptive responses of the venous network to a long-term gravitational load.
Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium.
Authors: Ognjanović BI , Pavlović SZ , Maletić SD , Žikić RV , Štajn AŠ , Radojičić RM , Saičić ZS , Petrović VM
Published: September 2023

The effects of acute exposure to cadmium (Cd) on the blood antioxidant defense system, lipid peroxide concentration and hematological parameters, as well as the possible protective role of vitamin E were studied. Male Wistar albino rats (3 months old) were treated with cadmium (0.4 mg Cd/kg b.m., i.p., 24 h before the experiment) or with vitamin E + Cd (20 IU Vit E/kg b.m., i.m., 48 h + 0.4 mg Cd/kg b.m., i.p., 24 h before the experiment). The hematological parameters were assessed: red blood cell counts, hematocrit value and hemoglobin concentration were significantly decreased in the blood of Cd-treated rats. Intoxication with cadmium was also followed by significantly increased lipid peroxide concentrations. We also observed increased activity of antioxidant defense enzymes: copper zinc containing superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase as well as concentrations of non-enzymatic components of antioxidant defense system: reduced glutathione, vitamin C and vitamin E. Pretreatment with vitamin E exhibited a protective role on the toxic effects of cadmium on the hematological values, lipid peroxide concentration as well as on enzymatic and non-enzymatic components of antioxidant defense system.
ANALYZING COLLECTIVE BEHAVIOURS IN FIFA WORLD CUP QATAR 2022
Authors: KARABIYIK Hakan , DURMUŞ Tugay
Published: September 2023

Performance analysis is integral to modern football, providing data-driven insights for enhancing strategies, player development, and tactical behaviour. Collective behaviours in football, akin to natural systems, have gained attention. Team coordination, passing networks, and player movement dynamics are critical for analysing performance and team cohesion. Factors such as team length and width contribute to understanding collective behaviour. This study explores factors influencing teams' performance in the FIFA World Cup Qatar 2022, including ball possession, field zones, team width, team length, distance to the goal line, and area covered by the team. This study examined 64 matches played among the 32 teams. Analysis reveals the significance of goal-scoring ability, highlighting that winning teams score significantly more goals than draws and losses. Contrary to common belief, ball possession percentages do not significantly differ among these outcomes, indicating its nuanced role. Within possession and out-of-possession phases, strategies like line height, team length, and team depth vary little across different outcomes, suggesting the effectiveness of balanced approaches. In the final third phase, winning teams employ higher defensive lines and deeper formations. In conclusion, this study illuminates the multifaceted nature of football performance. Goal-scoring ability and field zone-specific strategies play pivotal roles. Ball possession's influence is more complex than previously thought. Understanding these dynamics can inform teams and coaches for more informed and effective performance optimization, emphasizing the need for nuanced analysis and future research.
OVERVIEW OF SPORTS METAPHORS THROUGH VISUAL RHETORIC CLASSIFICATION IN THE CONTEXT OF THE POSTMODERN CONSUMER CULTURE
Authors: ÜNSAL YILMAZ Bahar , ŞAHİN Mehmet
Published: September 2023

Consumption has become a more comprehensive and broad concept, not just meeting human needs, with the formation of postmodern consumption culture. Consumption culture reveals its effect in almost every field, including sports, art, fashion, and daily basic needs. Sports activities, as a part of the culture, have made a difference in the industry, with many manufacturers and foundations being the focus of attention. This study examined visual metaphors with sports content. Moreover, this study also tried to investigate visuals with sports content that aim to change and transform society. The study examined the influential role of sports in reaching every segment of society in the context of consumer culture. In this study, we inspected the mediation of the Phillips and McQuarrie (2004) model, which constitutes the typology of visual metaphors used in advertisements in the images determined by the sampling method. The researchers used a qualitative analysis of the sports content visuals, which considered the metaphor types by using the content analysis method. In addition, the researchers took the approach of Roland Barthes, a semiotic theorist, as a basis and interpreted the texts next to the visual metaphors together. Unlike previous studies on metaphors’ usage in printed images, the researchers tried to explore the relationship between the types of sports visual metaphors through rhetoric and the postmodern consumption culture. The study revealed that the symbolic power of sports in postmodern consumption culture affected the development of a positive attitude in the change of society through images containing metaphors.
INVESTIGATION OF THE RELATIONSHIP OF COGNITIVE PERFORMANCE, VISUAL REACTION TIME AND AGILITY PARAMETERS ON FOOTBALL PLAYERS
Authors: DEMİR Okan , KIYICI Fatih
Published: September 2023

The research aims to examine the relationship between cognitive performance, visual reaction time and agility parameters on football players. Twenty- five football players with an average age of 18-20 years (18.16 ± 0.68), who have been active for at least five years and who are in the Turkish U19 Super League participated in the study from the Turkish U19 Super League participated. Body composition (BODPOD), agility (Illinois test), visual reaction time (Witty Sem Microgate) and cognitive performance (Stroop Test) of the football players were measured. SPSS v23 was used in the analysis of the data and the significance level was taken as p
ALTYAPI FUTBOL OYUNCULARININ MEVKİLERİNE GÖRE PROBLEM ÇÖZME, DİKKAT VE MOTİVASYON DÜZEYLERİNİN İNCELENMESİ
Authors: ÇINARGÜR Halil Emre , ERTURAN Gökçe
Published: September 2023

Öz: Genç futbolcuların potansiyellerine ulaşmalarını sağlayabilmek adına mevkilerinin gerektirdiği fiziksel-fizyolojik özellikler ile birlikte bilişsel ve duyuşsal özelliklerinin de incelenmesi önemlidir. Bu araştırmanın amacı, futbol altyapı oyuncularının problem çözme, dikkat ve motivasyon düzeylerinin oynadıkları mevkilere göre karşılaştırılmasıdır. Araştırma, Ege Bölgesinde profesyonel futbol takımlarının altyapılarında oynayan, 14-19 yaşları arasındaki 217 erkek (XYaş=16.01) futbolcu ile yapılmıştır. Futbolculara, Problem Çözme Envanteri, d2 Dikkat Testi ve Sporda Güdülenme Ölçeği, antrenmandan önce antrenörün olmadığı bir ortamda uygulanmıştır. Kruskal Wallis Varyans Analizi ile her bir değişkenin, oyuncuların mevkilerine göre farklılaşıp farklılaşmadığı incelenmiş, Tamhane Testi ile çoklu karşılaştırmalar yapılmıştır. Farklı mevkilerde oynayan altyapı oyuncularının problem çözme ve motivasyon düzeyleri arasında mevkilerine göre anlamlı fark bulunmamıştır. Stoperlerin konsantrasyon performansları sağ/sol forvet oyuncularınınkinden anlamlı düzeyde yüksek bulunmuştur. Antrenörlere altyapı oyuncularının problem çözme becerilerini geliştirecek ve içsel motivasyonlarını artıracak antrenman programları tasarlamaları önerilmektedir.
ACUTE EFFECTS OF FOAM ROLLER ON PERFORMANCE IN ELITE VOLLEYBALL PLAYERS
Authors: AKÇAY Neslihan , KAPLAN Samet , TANRIÖVER Sezer , PENÇEK Doğukan Ersan , AKGÜL Melike Nur , AKGÜL Mustafa Şakir
Published: September 2023

The aim of this study is to examine the acute effects of foam roller on performance after static and dynamic stretching exercises in elite volleyball players. A total of 8 male athletes with age average of 19.3±0.39 participated in the study voluntarily. The participants’ performance evaluations were carried out on two separate days, after stretching with stretching exercises and after foam roller exercise in addition to stretching with stretching exercises. 30 m sprint and agility performance of the participants were measured with a Smart Speed photocell. Flexibility measurements of the participants were performed with a standard sit-reach bench. A Smart Jump contact mat was used for active and multiple jump measurements of the participants. The data analysis was performed with SPSS 23.0 package program at 95% confidence interval (p
KADIN FUTBOLCULARA UYGULANAN TABATA ANTRENMANLARININ ANTROPOMETRİK, FİZİKSEL VE TEKNİK PERFORMANS PARAMETRELERİ ÜZERİNE ETKİSİ
Authors: GÜRKAN Oğuz , EYİBİL Muhammed Raşit , AKOT Barış , YÜCEL Necdet Can
Published: September 2023

Bu çalışma, kadın futbolculara uygulanan tabata antrenmanlarının antropometrik, fiziksel ve teknik performans parametreleri üzerine etkilerini araştırmak amacıyla yapılmıştır. Katılımcılar rastgele tabata grubu (n:10) ve kontrol grubu (n:10) olmak üzere iki gruba ayrılmışlardır. Tabata grubuna, kendi rutin branş antrenmanlarına ek olarak, 6 hafta boyunca haftada 2 gün, 2 set tabata antrenmanları yaptırılmış, kontrol grubu ise, kendi rutin futbol antrenmanlarına devam etmişlerdir. Çalışmanın başında ve sonunda tüm katılımcılara boy, kilo, BKİ, el pençe kuvveti, otur-eriş, dikey sıçrama, durarak uzun atlama, HÜFA, YOYO, 20 metre sürat, Mor&Christian pas ve şut testleri uygulanmıştır. Yapılan normallik testleri sonucunda, grup içi karşılaştırmalarda paired simple t testi, gruplar arası karşılaştırmalarda ise independent simple t testi uygulanmıştır. Çalışmamızda, tabata grubunun ön test-son test ölçümleri arasında el kavrama kuvvetinde istatistiksel olarak anlamlı bir gelişme olmasına rağmen (p0.05). Kontrol grubunun ön test-son test değerlerinde, squat sıçrama değişkeninde istatistiksel olarak anlamlı bir gelişme olmasına rağmen (p0.05). Sonuç olarak, 6 hafta boyunca haftada 2 gün uygulanan tabata antrenmanlarının kadın futbolcuların fiziksel ve teknik performans değişkenlerinin birçoğunda istatistiksel olarak anlamlı bir gelişme sağlamadığı ortaya konmuştur.
THE PREDICTION OF PHYSICAL AND MENTAL FATIGUE LEVEL IN THE USE OF ERGOGENIC SUPPORT OF ADOLESCENT ATHLETES
Authors: GÜLER Melek , AKPINAR Öznur
Published: September 2023

Being involved in the developmental period of adolescent athletes may cause more energy and fatigue levels. At this point, the correct and appropriate use of ergogenic supports can contribute to athletes. The study aims to reveal the predictors of fatigue and physical activity levels in adolescent athletes' use of ergogenic support. 171 (female: 98, male: 73) licensed athletes from the Provincial Directorate of Youth and Sports participated in the research voluntarily. Demographic information questionnaire, International Physical Activity Questionnaire-short form (IPAQ-SF), and Chalder Fatigue Scale were used in the research. The data collected in the study were analyzed in the Jamovi (2.0.0) statistical program at a 95% confidence interval and 0.05 significance level. In the analysis of the data, frequency (N), mean (x̄), standard deviation (ss), percentage (%), minimum (Min.), and maximum (Max.) values, Pearson's correlation and binomial logistic regression analysis were used. According to the findings of the study, most of athletes do not prefer to use ergogenic support. Those who use ergogenic support mostly use sports drinks, fish oil, and protein powder. Fatigue and total MET levels do not predict the use of ergogenic support by athletes. As a result, it can be said that adolescent athletes do not prefer to use ergogenic support and although their total MET scores are high, their fatigue levels are at a normal level.
Predictive factors of atrial fibrillation after coronary bypass surgery in a comparative Latin American cohort.
Authors: Blanco Camilo , Dulcey Luis , Ciliberti Maria , Theran Juan , Gomez Jaime , Amaya Maria , Quintero Aldahir , Hernandez Carlos , Caltagirone Raimondo , Martinez Juan , Mayorca Juan , Cala Maria , Lizcano Angie , Gutierrez Emily , Vargas Jorge , Estevez Maria , Castillo Silvia , Acevedo Diego , Chaves Melissa , Contreras Kerlyn , Cespedes Nikoll , Parales Rafael , Cabrera Valentina , Camargo Valentina , Cordoba Yaritza , Cortes Mariana , Castillo Juan
Published: September 2023

Introduction: Among all cardiovascular complications in patients after cardiac surgery, new-onset postoperative atrial fibrillation is one of the most common and develops in 30-50% of cases. Methodology: Original cohort study that was carried out in a South American level IV hospital from 2015-2018. Results: the mean age in the main group was 67.00 (61.00; 72.75) years, in the control group, 62.50 (57.25; 67.00) years (r =0.22; 95% CI: 0.02-0.43; p =0.04). In our study, the risk according to the EuroSCORE II scale in patients in the control group was 0.90 (0.72; 1.77) % and 1.29 (0.81; 2.51) % in patients in the control group. In the main, group was associated with the development of AF according to the results of the correlation analysis, r = 0.28, 95%; CI 0.06—0.47; p=0.01. Conclusions: In the case of atrial fibrillation in CBAG studies are required that better characterize our Latin American populations.
Peningkatan Kemampuan Literasi dan Numerasi Melalui Model Pembelajaran
Authors: Andri Nurcahyono Novi
Published: September 2023

Kemampuan literasi numerasi peserta didik di Indonesia masih kurang atau cukup rendah dan masih harus terus ditingkatkan. Salah satu upaya yang dilakukan untuk meningkatkan kemampuan literasi numerasi peserta didik adalah menerapkan model pembelajaran yang dapat menunjang berkembangnya kemampuan tersebut. Penerapan model pembelajaran yang tidak sesuai akan mengakibatkan kemampuan literasi dan numerasi kurang dapat berkembang. Penelitian ini bertujuan untuk memberikan pengetahuan mengenai model-model pembelajaran yang dapat digunakan untuk meningkatkan kemampuan literasi numerasi dalam pembelajaran matematika. Penelitian ini merupakan hasil literature review tentang model-model pembelajaran yang diterapkan dalam meningkatkan kemampuan literasi numerasi dalam pembelajaran matematika. Literature yang digunakan merupakan jurnal di dalam database google schoolar dengan rentang waktu kapan saja. Menggunakan kata kunci peningkatan dan “kemampuan literasi” dan “kemampuan numerasi” dan “model pembelajaran” diperoleh 216 hasil berupa semua jenis artikel. Berdasarkan analisis judul dan abstrak, terdapat 13 artikel yang sesuai mengenai model pembelajaran yang dapat meningkatkan kemampuan literasi numerasi peserta didik. Model Problem Based Learning, Discovery Learning, Project Based Learning, Inquiry Based Learning, Kooperatif Teams Games Tournament, Realistic Mathematics Education, Blanded Learning, dan Amati Tiru Kerjakan adalah model-model pembelajaran yang dapat meningkatkan kemampuan literasi dan numerasi peserta didik.
Penerapan Pembelajaran Aktif tipe Pengajuan dan Pemecahan Masalah dalam Upaya Meningkatkan Kemampuan Komunikasi Matematis Siswa
Authors: Najma Fadilah Suhada  , Agus Hikmat Syaf  , Sugilar Hamdan
Published: September 2023

Penelitian ini merupakan penelitian kuasi eksperimen dengan design Nonequivalent control grup design. Instrumen yang digunakan adalah tes dan non tes. Hasil penelitian ini yaitu; (i) Keterlaksanaan proses pembelajaran guru dan siswa berada pada kategori sangat baik; (ii) Kemampuan komunikasi matematis siswa yang memperoleh pembelajaran konvensional model ekspositori termasuk dalam kategori sangat kurang; (iii) Kemampuan komunikasi matematis siswa yang memperoleh pembelajaran aktif tipe pengajuan dan pemecahan masalah (JUCAMA) termasuk dalam kategori sangat kurang; (iv) Peningkatan kemampuan komunikasi matematis siswa yang menggunakan model pembelajaran aktif tipe pengajuan dan pemecahan masalah (JUCAMA) lebih baik dibandingkan siswa yang menggunakan pembelajaran konvensional model ekspositori; serta (v) Siswa kebanyakan merespon positif terhadap pembelajaran matematika menggunakan model pembelajaran aktif tipe pengajuan dan pemecahan masalah (JUCAMA).
PEMBELAJARAN SENI RUPA BERDASARKAN PERSPEKTIF KURIKULUM MERDEKA DI SEKOLAH DASAR
Authors: Azis Adek Cerah Kurnia , Lubis Siti Khodijah
Published: September 2023

Updating the curriculum to become the Merdeka Curriculum is a recovery solution of the learning process. The Merdeka Curriculum is of course different from the previous curriculum, both in terms of teaching tools, implementation, and assessment. This research aims to describe art learning based on the perspective of the Merdeka Curriculum in Elementary Schools. The research method used is qualitative descriptive. The research data is in the form of secondary data, by collecting data based on exploration from various literature. Data analysis techniques include data reduction, presentation of the data, and conclusion/verification. Results of applying the Merdeka Curriculum to fine arts learning based on student Phases. Time allocation of fine arts learning 2 hours of lessons (JP) per week. The teaching tools for the Merdeka Curriculum in Elementary Schools include teaching modules, projects to strengthen Pancasila Student Profiles and textbooks. Textbooks in fine arts learning do not have guidebooks for students, is only have teacher guidebooks, causing 77% of teachers to experience difficulties in carrying out the learning process. Teachers need to collaborate with colleagues of the same subject teachers to make student books,and look for additional teaching materials from various other references.
PEMBUATAN VIDEO TUTORIAL SEBAGAI MEDIA PEMBELAJARAN IKAT CELUP TEKNIK JUMPUTAN KELAS V SEKOLAH DASAR
Authors: Cynthia Ririn , Saleh Khaerul
Published: September 2023

In Indonesia, tie-dye is called jumputan. Jumputan fabrics are well-known and admired by many people because the process is purely han made and the motifs are unique. The limitation of this research problem is the influence of the use of tutorial media on students' learning interest in the tie-dye material jumputan technique for fifth-grade students at SDS Muhammadiyah 6 Medan. The purpose of this study was to determine students' interest in learning after using video tutorial-based learning media in the tie-dye jumputan technique, and to describe learning outcomes using video tutorials for fifth-grade students at SDS Muhammadiyah 6 Medan. The type of research used is Research and Development (R&D). The research subjects used by researchers were Probability Sampling with the aim of researchers making decisions that were of concern to this study were fifth-grade students at SDS Muhammadiyah 06 Medan in small groups of 18 people. From the overall results of the students' work above, there is a difference between the work before and after the existence of the learning tie-dye jumputan technique, namely the most prominent of the color intensity, in which the dyed color is not absorbed properly because in the coloring process, students use plain water so that the resulting color is less concentrated white spots on the cloth. The making of a tie-dye tutorial video for the jumputan technique for fifth class students at SDS Muhammadiyah 6 Medan carry out in three stages, namely pre-production, production, and post-production. The use of video tutorials in learning the jumputan tie-dye technique is consider a method that can improve student learning outcomes, as well as assist teachers in providing audio-visual understanding in the teaching and learning process.
КРУГЛЫЙ СТОЛ «ДОСТУП К МЕДИЦИНСКИМ РЕСУРСАМ В ПЕРИОД ПАНДЕМИИ COVID-19» И ОБСУЖДАЕМЫЕ ПРОБЛЕМЫ
Authors: Адамович А.Ю. , Сокольчик В.Н.
Published: September 2023

В обзорной статье авторы обозначают основные вопросы, обсуждению которых был посвящен круглый стол «Проблемы доступа к медицинским ресурсам в ситуации COVID-19», состоявшийся 19 мая 2022 года в рамках конференции «Пандемия COVID-19 в пространстве и времени: в интерпретациях специалистов в области биоэтики, психиатрии, общественного здоровья и здравоохранения». Авторы знакомят читателя с деятельностью Республиканского Центра Биоэтики (Беларусь, Минск), приоритетами и направлениями его деятельности. Названы основные докладчики и рассматриваемые ими актуальные вопросы. При этом достаточно подробно рассматриваются проблемы, обсуждавшиеся в докладах участников круглого стола, а также последовавшая за ними дискуссия. Особо отмечены сложности доступа к медицинской помощи в период пандемии. Рассматривается не только непосредственная возможность получить лечение/консультацию, но особенности информирования населения. Анализируются особенности принятия вакцинации; акцентируются психологические проблемы пациентов и их родственников и многое другое.
УРОКИ ПАНДЕМИИ СКВОЗЬ ПРИЗМУ БИОЭТИКИ
Authors: Сокольчик В.Н.
Published: September 2023

Статья актуализирует вопросы взаимодействия общества, индивида и системы здравоохранения в ситуации пандемии COVID-19. Осмысляя пандемический опыт Республики Беларусь, автор анализирует важные проблемы, связанные с реализацией биоэтических принципов автономии личности и справедливости, рассматривает значимость информации и информирования в чрезвычайной ситуации как способа психологической защиты общества. Акцентируются темы доверия системе здравоохранения, обучения медицинских работников этическим и коммуникативным навыкам, оценивается роль волонтерского движения в периодпандемии. По мнению автора, понимание этих важнейших проблем предшествует осмыслению и извлечению уроков, необходимых для совершенствования системы здравоохранения и ее ответа на чрезвычайные ситуации.
ОБСУЖДЕНИЕ СОВРЕМЕННЫХ ИССЛЕДОВАНИЙ МЕДИЦИНСКИХ ПРАКТИК ПЛЕМЕН ИНДИИ НА Х МЕЖДУНАРОДНОМ КОНГРЕССЕ МЕДИЦИНСКИХ АНТРОПОЛОГОВ
Authors: Копелиович Г.Б. , Гандгадхар М.Р.
Published: September 2023

В обзорной статье авторы рассматривают основные темы и доклады, прозвучавшие в рамках секции «Передача медицинских знаний в локальных сообществах в Индии», состоявшейся во время Х Международного интердисциплинарного научно-практического конгресса медицинских антропологов в Москве (ИЭА РАН; онлайн). Докладчики познакомили слушателей с исследованиями медицинских практик племен запада, севера и юга Индии. Секция была организована в партнерстве с Департаментом Антропологии Университета Майсура (Карнатака: Индия) и с Ассоциацией медицинских антропологов Индии (Майсур). Передача медицинских знаний в локальных сообществах является актуальной темой в индийской антропологии, поэтому вызвала большой интерес у индийских антропологов. Одним из главных спикеров был профессор П.С. Джоши – крупнейший медицинский антрополог Индии, изучавший много лет медицинские практики различных индийских племен. В конференции принял участие доктор Кшатри, который долгое время посвятил исследованиям племен Бхил, проживающих в разных частях Индии. Большой интерес вызвал доклад профессора Аарти Нагаркар. Профессор является руководителем департамента наук о здоровье Университета Пуны; её исследование было посвящено практикам традиционной народной медицины в пренатальном и постнатальном периоде. Данная работа была выполнена при участии врачей западной медицины, антропологов и социологов медицины. В целом секция вызвала большой интерес, было много вопросов и уточнений от российской аудитории.
Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression
Authors: Wang Xiaoying , Zhu Liyun , Zhou Jianhui , Zhao Lingzhou , Li Jingchao , Liu Changcun
Published: September 2023

Introduction: Although various therapies have been adopted to treat cancer, metastasis of tumor cells still is a big challenge that compromises therapeutic benefits.

Methods: We herein report an injectable drug-loaded hybrid hydrogel that can achieve sonodynamic therapy (SDT) and chemodyanmic therapy (CDT) combined action and suppression of tumor metastasis. This alginate (ALG)-based hydrogel (termed as AMPS) contains manganese dioxide (MnO2) nanoparticles as the CDT agents, an organic polymer as the sonosensitizer, and a SIS3 drug as metastasis inhibitor.

Results: AMPS is formed via the chelation of ALG by Ca2+ in tumor microenvironment, in which MnO2 nanoparticles mediate CDT via Fenton-like reaction and the organic polymers enable SDT under ultrasound (US) irradiation by generating singlet oxygen (1O2), allowing for combinational action of CDT and SDT. In addition, SIS3 is released from AMPS hydrogels to inhibit the metastasis of tumor cells. As such, the AMPS enables a combinational action of SDT and CDT to greatly inhibit the growths of subcutaneous tumors in living mice and also completely suppress the tumor metastasis in lungs and livers.

Conclusion: This study thus offers a hybrid hydrogel platform for combinational therapy and metastasis suppression simultaneously.
Cell-specific secretory granule sorting mechanisms: the role of MAGEL2 and retromer in hypothalamic regulated secretion
Authors: Štepihar Denis , Florke Gee Rebecca R. , Hoyos Sanchez Maria Camila , Fon Tacer Klementina
Published: September 2023

Intracellular protein trafficking and sorting are extremely arduous in endocrine and neuroendocrine cells, which synthesize and secrete on-demand substantial quantities of proteins. To ensure that neuroendocrine secretion operates correctly, each step in the secretion pathways is tightly regulated and coordinated both spatially and temporally. At the trans-Golgi network (TGN), intrinsic structural features of proteins and several sorting mechanisms and distinct signals direct newly synthesized proteins into proper membrane vesicles that enter either constitutive or regulated secretion pathways. Furthermore, this anterograde transport is counterbalanced by retrograde transport, which not only maintains membrane homeostasis but also recycles various proteins that function in the sorting of secretory cargo, formation of transport intermediates, or retrieval of resident proteins of secretory organelles. The retromer complex recycles proteins from the endocytic pathway back to the plasma membrane or TGN and was recently identified as a critical player in regulated secretion in the hypothalamus. Furthermore, melanoma antigen protein L2 (MAGEL2) was discovered to act as a tissue-specific regulator of the retromer-dependent endosomal protein recycling pathway and, by doing so, ensures proper secretory granule formation and maturation. MAGEL2 is a mammalian-specific and maternally imprinted gene implicated in Prader-Willi and Schaaf-Yang neurodevelopmental syndromes. In this review, we will briefly discuss the current understanding of the regulated secretion pathway, encompassing anterograde and retrograde traffic. Although our understanding of the retrograde trafficking and sorting in regulated secretion is not yet complete, we will review recent insights into the molecular role of MAGEL2 in hypothalamic neuroendocrine secretion and how its dysregulation contributes to the symptoms of Prader-Willi and Schaaf-Yang patients. Given that the activation of many secreted proteins occurs after they enter secretory granules, modulation of the sorting efficiency in a tissue-specific manner may represent an evolutionary adaptation to environmental cues.
Case report: Heart transplant for persistent right heart failure after complete surgical repair and percutaneous closure of post-myocardial infarction ventricular septal rupture
Authors: Garg Pankaj , Lykins Amy , Alomari Mohammad , Pollak Peter , Patel Parag , Sareyyupoglu Basar
Published: September 2023

The incidence of post-acute myocardial infarction ventricular septal rupture (post-AMI VSR) has decreased; however, mortality after surgical repair of post-AMI VSR remains high. Patients who are not surgical candidates can be managed by heart transplant with a good outcome. A heart transplant in a patient after successful repair of VSR has never been reported. We report a patient who had persistent right heart failure after the successful repair of VSR and underwent a heart transplant with a good outcome.
Hypertension evaluated in the public and private Brazilian health system hypertension in public and private service
Authors: Amorim Kecia C. F. O. , Vitorino Priscila Valverde O. , Feitosa Audes D. M. , Santos Mayara Cedrim , Bezerra Rodrigo , Lopes Lais Rocha , Camafort Miguel , Coca Antonio , Sousa Ana Luíza Lima , Barroso Weimar K. S.
Published: September 2023

Introduction

Hypertension (HT) remains the leading cause of death worldwide. In Brazil it is estimated that 35% of the adult population has HT and that about 20% of these have blood pressure values within the targets recommended for the reduction of cardiovascular risk. There are some data that point to different control rates in patients treated by cardiologists in public and private referral center and this is an important point to be investigated and discussed.

Objective

To compare sociodemographic characteristics, body mass index (BMI), antihypertensive (AH) drugs, blood pressure (BP) and control rate in public (PURC) and private (PRRC) referral centers.

Methodology

A cross-sectional multicenter study that analyzed data from hypertensive patients assisted by the PURC (one in Midwest Region and other in Northeast region) and PRRC (same distribution). Variables analyzed: sex, age, BMI, classes, number of AH used and mean values of systolic and diastolic BP by office measurement and home blood pressure measurement (HBPM). Uncontrolled hypertension (HT) phenotypes and BP control rates were assessed. Descriptive statistics and χ2 tests or unpaired t-tests were performed. A significance level of p < 0.05 was considered.

Results

A predominantly female (58.9%) sample of 2.956 patients and a higher prevalence of obesity in PURC (p < 0.001) and overweight in PRRC (p < 0.001). The mean AH used was 2.9 ± 1.5 for PURC and 1.4 ± 0.7 for PRRC (p < 0.001). Mean systolic and diastolic BP values were higher in PURC as were rates of uncontrolled HT of 67.8% and 47.6% (p < 0.001) by office measurement and 60.4% and 35.3% (p < 0.001) by HBPM in PURC and PRRC, respectively.

Conclusion

Patients with HT had a higher prevalence of obesity in the PURC and used almost twice as many AH drugs. BP control rates are worse in the PURC, on average 15.3 mmHg and 12.1 mmHg higher than in the PRRC by office measurement.
The safety and efficacy of direct oral anticoagulants among chronic kidney disease patients on dialysis with non-valvular atrial fibrillation: a meta-analysis
Authors: Mapili Jerahmeel Aleson L. , Lim Lloyd Christopher S. , Velando Bianca M. , Aherrera Jaime Alfonso M.
Published: September 2023

Background

Individuals with chronic kidney disease (CKD) on dialysis are at an increased risk of stroke and embolic events especially in the presence of atrial fibrillation (AF). Vitamin K antagonists (VKA), including warfarin, have been used for decades for anticoagulation among CKD patients on dialysis with AF but recent evidence has shown increased bleeding. Direct oral anticoagulants (DOAC) have been emerging as an alternative to VKA which, based on several observational cohort studies, are at least as efficacious and safe as VKA. This meta-analysis looked into the safety and efficacy of DOACs compared to VKA among CKD patients on dialysis with non-valvular AF.

Methodology

This study used a random-effects meta-analysis using RevMan 5.4. PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov were searched from their dates of inception to June 2023. The risk of bias was assessed using Cochrane RoB2 and the certainty of evidence was assessed using GRADE.

Results

This meta-analysis showed that DOACs when compared to VKA have no significant difference in terms of risk for major bleeding (RR = 0.81, 95% CI 0.46–1.43), ischemic stroke (RR = 0.5, 95% CI 0.19–1.35), and cardiovascular death (RR = 1.34, 95% CI 0.69–2.60).

Discussion

This meta-analysis adds to the growing body of evidence supporting that the use of DOACs has similar efficacy and safety outcomes in CKD patients on dialysis with non-valvular AF patients compared to VKA. The findings need to be replicated in larger and more adequately powered clinical trials in order to ascertain its level of evidence.
An intelligent telemonitoring application for coronavirus patients: reCOVeryaID
Authors: D'Auria Daniela , Russo Raffaele , Fedele Alfonso , Addabbo Federica , Calvanese Diego
Published: September 2023

The COVID-19 emergency underscored the importance of resolving crucial issues of territorial health monitoring, such as overloaded phone lines, doctors exposed to infection, chronically ill patients unable to access hospitals, etc. In fact, it often happened that people would call doctors/hospitals just out of anxiety, not realizing that they were clogging up communications, thus causing problems for those who needed them most; such people, often elderly, have often felt lonely and abandoned by the health care system because of poor telemedicine. In addition, doctors were unable to follow up on the most serious cases or make sure that others did not worsen. Thus, uring the first pandemic wave we had the idea to design a system that could help people alleviate their fears and be constantly monitored by doctors both in hospitals and at home; consequently, we developed reCOVeryaID, a telemonitoring application for coronavirus patients. It is an autonomous application supported by a knowledge base that can react promptly and inform medical doctors if dangerous trends in the patient's short- and long-term vital signs are detected. In this paper, we also validate the knowledge-base rules in real-world settings by testing them on data from real patients infected with COVID-19.
A new assemblage of late Neanderthal remains from Cova Simanya (NE Iberia)
Authors: Morales Juan I. , Cebrià Artur , Soto María , Rodríguez-Hidalgo Antonio , Hernando Raquel , Moreno-Ribas Elena , Lombao Diego , Rabuñal José R. , Martín-Perea David M. , García-Tabernero Antonio , Allué Ethel , García-Basanta Andrea , Lizano Esther , Marquès-Bonet Tomàs , Talamo Sahra , Tassoni Laura , Lalueza-Fox Carles , Fullola Josep M. , Rosas Antonio
Published: September 2023

This study presents an exceptional collection of 54 Late Pleistocene human remains that correspond to at least three Neanderthal individuals from Simanya Gran, the main gallery of Cova Simanya, located in the northeastern Iberian Peninsula. The collection comprised 53 unpublished remains that were unearthed during the 1970s and an additional tooth discovered during 2021 excavations. The specimens represent an adult with a small stature, a periadolescent aged approximately 11.5 years, and an immature individual aged approximately 7.7 years, thus offering a more complete demographic perspective. The collection encompasses diverse anatomical parts including upper and lower dentition, mandible, vertebrae, and limb bones from both the upper and lower extremities. Attempts to extract aDNA were unsuccessful. Renewed archaeological investigations at Cova Simanya have facilitated the reevaluation of the original stratigraphic context of these remains, leading to the discovery of the additional tooth, aligning with the periadolescent individual. This assemblage is currently the most extensive Neanderthal collection from the northeastern Mediterranean Iberia, offering invaluable insights into the morphology and evolutionary trajectory of Late Pleistocene hominins. Hence, Simanya Neanderthals will enhance our understanding of Neanderthal demographics and evolution, paving the way for an in-depth examination of the morphological diversity and evolutionary context of Iberian Neanderthals.