bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS RISIKO PRODUKSI USAHATANI SAYURAN DI KABUPATEN LOMBOK UTARA
Authors: Tanaya I Gusti Lanang Parta , Rosmilawati Rosmilawati , Hidayati Asri
Published: September 2021

Komoditas sayuran merupakan salah sayu komoditas andalan yang diharapkan karena rata-rata berumur pendek dan dapat diproduksi di lahan yang sempit.  Di samping memiliki keunggulan, usahatani sayuran juga memiliki kendala yang cukup berat yakni tingginya tingkat risiko yang dihadapi.  Oleh sebab itu maka tujuan penelitian ini adalah untuk mengetahui risiko produksi yang dihadapi oleh petani sayuran dan strategi penanganan yang dapat diterapkan oleh petani sayuran untuk menangani risiko produksi di Kabupaten Lombok Utara.  Penelitian ini dilakukan pada dua kelompok tani yaitu Poktan Horseka dan Poktan Hijau Daun dengan total responden 30 orang.  Hasil penelitian menunjukkan bahwa usahatani cabe memiliki risiko produksi yang paling besar berdasarkan tingkat produktivitas dengan nilai Koefisien Variasi atau KV = 0,54 dibandingkan dengan kacang panjang (0,32), mentimun jepang (0,36) dan tomat (0,42).  Penyebab utamanya adalah faktor cuaca, serangan hama lalat buah dan serangan penyakit antraknose.  Komoditas yang memiliki risiko produksi berdasarkan pendapatan terbesar adalah tomat dengan nilai KV = 0,48.  Penyebab utamanya adalah biaya produksi tanaman tomat rata-rata lebih tinggi dibandingkan tanaman lainnya seperti cabe, kacang panjang dan mentimun jepang. Untuk memperkecil risiko produksi sayuran di KLU maka petani sebaiknya melakukan pengelolaan lingkungan areal usahatani dengan baik melalui kegiatan penanaman tanaman pelindung, penanaman tanaman pengusir hama atau penjebak hama (crop trapping) dan memperbanyak penggunaan pupuk kandang.
Peritumoral Lymphangiogenesis in Breast Carcinoma
Authors: S.K. Gantsev  , S.R. Kzyrgalin  , K.S. Gantsev
Published: September 2021

Objective: to assess the correlation between microscopically discernible peritumoral lymphangiogenesis and breast carcinoma survival rates; to reveal the regularities of macroscopic changes in the structure of axillary lymphatic system in breast cancer. Materials and Methods: We carried out morphometric examination of axillary tissue complexes that had been taken from 100 women during surgery for breast carcinoma, stage T1-3N1-2M0 and had been treated with sonolipodistruction. The density of realized lymphatic vessels was determined by counting the number of lymphangiogenesis "points". An anastomosis between individual lymphatic vessels was taken as a "point". Correlation of macroscopically distinguishable peritumoral lymphangiogenesis expression and survival rate was determined using Pearson's parametric analysis. Results: The analysis of lymphatic maps allowed us to reveal some patterns of axillary lymphatic collector reorganization in breast carcinoma and to distinguish the following types: "Sequential", "Magistral", "Uniform", "Radial" and "Reticulate". Based on the results of prospective observation, 16 patients from the observation group died within the period of 5 years. According to the Pearson correlation analysis, the correlation coefficient was 0,87, the determination coefficient was 0,7488, the value of p = 0,000015, which indicates that in the breast carcinoma, stage T1-3 N1-2 M0 there is a statistically significant direct correlation between the number of "points" of macroscopically distinguishable peritumoral lymphangiogenesis and lifespan after a radical surgical treatment. Lymphatic vessels in the process of peritumoral lymphangiogenesis are the indicator of compensatory-protective resources condition.
Clinical Analysis of Apatinib in the Treatment of Patients with Residual Tumor after Radical Chemoradiotherapy for Locally Advanced Cervical Cancer
Authors: Jun Jiang  , Wei Hong Wei  , Tao Xu
Published: September 2021

There is no standard treatment for locally advanced cervical cancer, patients with residual tumor after radical concurrent chemoradiotherapy. This study was to investigate the short-term efficacy and safety of the targeted drug apatinib mesylate in patients with tumor residual after radical chemoradiotherapy for locally advanced cervical cancer. Eight patients with residual tumors after localized concurrent chemoradiotherapy with locally advanced cervical cancer were treated with apatinib (250 mg once daily, orally). The short-term efficacy and safety of the eight patients treated with apatinib were initially evaluated. Total Effectiveness (ORR) 37.5% and disease control rate (DCR) 100.0%. The toxicity and side effects were light, mainly manifested as 37.5% of hand-foot syndrome, 37.5% of proteinuria, 25.0% of hypertension, 12.5% of fatigue, 12.5% of rash, and 12.5% of vomiting. No serious toxic side effects associated with the drug were observed. Apatinib mesylate can be safely used in patients with residual tumor after radical chemoradiotherapy for locally advanced cervical cancer. The short-term effect is positive and the side effects are low.
Diagnostic and Prognostic DNA-Karyometry for Cancer Diagnostics
Authors: Alfred Böcking  , David Friedrich  , Branko Palcic  , Dietrich Meyer-Ebrech  , Jin Chen
Published: September 2021

Diagnostic and prognostic DNA-karyometry represents an automated computerized microscopical procedure, designed to improve cancer diagnostics at three different aspects:

Screening for cancer cells, e.g. in body cavity effusions, urines or mucosal smears
Specifying the risk of dysplasias or borderline lesions to progress to manifest cancer, e.g. of oral, bronchial or cervical mucosa, or the ovary.
Grading the malignancy of certain tumors, like prostate cancer.

It combines an automated diagnostic classification of Feulgen-stained nuclei with precise nuclear DNA-measurements. DNA-aneuploidy is used as a specific marker of malignancy and its degree for grading.
All types of cytological specimens can be used after (re-)staining specific for DNA according to Feulgen. Histological specimens are subjected to enzymatic cell separation before Feulgen-staining.
A video-slide scanner is used for automated scanning of microscopical slides. Diagnostic nuclear classifiers have tissue-specifically been trained by an expert-cytopathologist (A. B.), based on Random Forest Classifiers, applying 18 different morphometric features. They achieve an overall accuracy of 91.1% to differentiate 8 differents types of objects/nuclei. Nuclear DNA-measurements of diploid nuclei achieve a CV of <3%. DNA-stemline-aneuploidy, applied as a 100% specific marker for malignancy, is detected and quantified, using internationally accepted algorithms (ESACP 1995-2001). Suspicion of malignancy is raised in the absence of DNA-aneuploidy but presence of >1% morphometrically abnormal nuclei.
Time needed for loading, scanning and validation of results per slide is about 10 minutes. Results of digital diagnostic nuclear classification can be verified by a cytopathologist, using image galleries. Likewise automated diagnostic interpretation of nuclear DNA-distributions can be checked on the monitor, before a pathologists validated diagnoses are issued.
Screening-results are presented for body cavity effusions and urines. Evaluations of dysplasias are reported for oral, bronchial and cervical smears. Results of grading malignancy are shown for prostate cancers.
S-1 Plus Leucovorin and Oxaliplatin in Combination with Lentinan as First-line Therapy in Patients with Metastatic Gastric Cancer
Authors: Kenji Ina  , Ryuichi Furuta  , Megumi Kabeya  , Takashi Yoshida  , Takae Kataoka  , Satoshi Kayukawa
Published: September 2021

Background: Metastatic gastric cancer has a poor prognosis, despite recent therapeutic improvements. The phase 3 SOLAR study confirmed better efficacy of S-1, oxaliplatin, and leucovorin (SOL) than S-1 plus cisplatin in advanced gastric cancer. Lentinan, (1, 3)-glucan purified from Shiitake mushrooms, has been reported to improve the overall survival of cancer patients receiving chemotherapy. We conducted a preliminary study of SOL combined with lentinan during these 4 years.
Methods: The clinical study was approved by the ethics committee of Nagoya Memorial Hospital in 2016. After explaining the protocol of this study, patients with recurrent or unresectable gastric cancer were enrolled, if they had the intention to participate. Medical records were retrospectively reviewed to determine the objective response rate (ORR), disease control rate, overall survival, and adverse effects.
Results: Twelve patients (age: 59-81 years; sex: 9 men, 3 women) with metastatic gastric cancer (liver: 3, lung: 2, peritoneal: 12, ascites: 9) were treated with SOL in combination with lentinan as the first-line regimen. The cycles ranged from 4 to 15. The ORR and disease control rates were 58.3% (complete response [CR], 1; partial response, 6) and 91.7%, respectively. One patient with CR survived for > 23 months after the initiation of chemotherapy. Concerning adverse events, peripheral neuropathy was the most common event observed in all patients. However, there were no severe side effects, such as febrile neutropenia and diarrhea.
Conclusions: SOL combined with lentinan can be a promising option for the treatment of far advanced metastatic gastric cancer.
Advances in New Targets for Differentiation Therapy of Acute Myeloid Leukemia
Authors: Jingfang Yao  , Mengjie Zhao  , Jiangyun Wang  , Liuya Wei
Published: September 2021

Acute myeloid leukemia (AML) is a clinical and genetic heterogeneous disease with a poor prognosis. Recent advances in genomics and molecular biology have immensely improved the understanding of disease. The advantages of syndrome differentiation and treatment are strong selectivity, good curative effect and lesser side effects. In recent years, according to the molecular mechanism of acute myeloid leukemia, many new therapeutic targets have been found. New targets of differentiation therapy in recent years, such as cell cyclin-dependent kinase (CDK2), isocitrate dehydrogenase (IDH1, IDH2), Homeobox genes (HoxA9), Dihy-droorotate dehydrogenase (DHODH) and some others, are reviewed in this article.
A Marine Natural Products as Modulators of Multidrug Resistance
Authors: Tatjana P. Stanojkovic  , Sanja Milovic
Published: September 2021

Multidrug resistance (MDR) which enable the tumor cells to possess intrinsic or acquired cross resistance to multiple chemotherapeutic agents simultaneously is considered to be a major challenge in cancer chemotherapy during the 21st century. numerous efflux pumps and transport proteins have been found to play important roles in MDR either the phenomenon of lowering the total intracellular retention of chemotherapeutic drugs or the redistribution of intracellular accumulation of drugs away from target organelles are two of the basic mechanisms involved in this process of MDR by transmembrane proteins which are expressed in varying concentrations in different neoplasms. Multiple compounds that have the potential to inhibit these pumps or proteins can be a future prospective for adjuvant treatment of neoplastic conditions. In this regard, compounds derived from natural products bear the advantages of low-cost and relative nontoxicity thus providing a great pool of lead structures for chemical derivatizations. This review gives an overview on chemical substances isolated from natural products of marine origin which possess the MDR modulating properties
RNA-Sequencing-Based lncRNA Biomarker Profiling on Triple Negative Breast Cancer
Authors: Gao Lin , Yang Qinhe , Zhou Wenbin , Dai Yong , Wang Jigang , Fu Li , Zhao Pan , Huang Jingy , Hong Malin , Xia Jinquan , Zou Chang
Published: September 2021

Abstract: Basal-like triple-negative breast cancer (TNBC) is highly heterogeneous and lack of effective molecular targets for therapy. In this study, we developed the lncRNA signatures of TNBC as molecular biomarkers. RNA-sequencing in 12 paired breast cancer and adjacent tissues identified up-regulated and down-regulated lncRNAs of Basal subtype in contrast to Luminal A, Luminal B and HER2 subtypes. Additionally, Kaplan-Meier analysis revealed that high expression of lncRNA (ZEB1-AS1 and TMEM254-AS1) had a poor relapse-free survival rate (RFS), while high expression of lncRNA (LINC01087, LINC01122 and LINC00856) had a positive correlation with RFS. Furthermore, qRT-PCR analysis showed that the mRNA expressions of the ZEB1-AS1 and TMEM254-AS1 lncRNA were up-regulated in TNBC tissues, while the mRNA expression of lncRNA, including LINC01087, LINC01122 and LINC00856 were down-regulated in TNBC tissues. Taken together, our results elucidated that 5 novel lncRNAs, including ZEB1-AS1, TMEM254-AS1, LINC01087, LINC01122 and LINC00856 contributed to the progression of invasive TNBC. These lncRNAs could be molecular biomarkers for the development of TNBC treatment.

Keywords: TNBC, long noncoding RNA (lncRNA), RNA-sequencing, ZEB1-AS1, TMEM254-AS1, LINC01087, LINC01122, LINC00856.
Activated Charcoal Pellets as an Innovative Method for Forensic Analysis of Ignitable Liquid Residues from Fire Debris by GC-MS
Authors: Carmona Lais , Campos Eduardo , Bigão Vítor Luiz , Pereira Ana Luiza , Maia Flávia , Telles Laíza , De Martinis Bruno
Published: September 2021

In Forensic Chemistry, evidence collected at a crime scene is of paramount importance for any case to be properly elucidated. Ignitable liquid residues are important chemical evidence in investigations into cases of fire because these substances can be correlated to arson. Here, we describe an innovative technique for sampling and extracting gasoline and diesel from fire debris by using activated charcoal pellets (ACP). ACP can be an alternative to activated charcoal strips and can be easily produced on the laboratory scale. The ACP approach allowed all the target compounds selected for gasoline and diesel fuels to be extracted. Among the six tested extraction conditions, optimal extraction occurred at 100 °C, after 240 min. These preliminary results showed the potential of ACP for detecting gasoline and diesel in fire debris. However, the ACP approach still requires analytical validation, so that its applicability in an authentic forensic setting can be explored.
Sistem Peramalan Persediaan Sparepart Menggunakan Metode Weight Moving Average dan Reorder Point
Authors: Suhendra Cindy Ameilia , Asfi Marsani , Lestari Widya Jati , Syafrinal Ilwan
Published: September 2021

SM Teknik menjual sparepart sepeda motor, perkakas teknik, perkayuan serta jasa perbaikan mesin pertukangan dan mesin bubut corer. SM Teknik mengalami kesulitan dalam mempredikasi jumlah persediaan sparepart untuk pengadaan kembali. Data historis penjualan SM Teknik selama ini masih terdata dengan pencatatan manual. Oleh karena itu perlu dikembangkan suatu sistem berbasis komputer. Pengembangan sistem berbasis komputer menggunakan metode waterfall dengan tahapan analisis sistem, desain sistem, implementasi sistem dan pengujian sistem. Sistem dibangun dengan bahasa pemrograman PHP dengan DBMS mySQL. Metode peramalan menggunakan metode weighted moving average (WMA) untuk prediksi jumlah stok sparepart yang harus dibeli untuk periode selanjutnya. Penentuan batas aman persediaan menggunakan metode Reorder Point (ROP). Data historis dalam penelitian ini adalah data aktual penjualan sparepart dari bulan Januari sampai dengan Desember 2018. Hasil peramalan sparepart untuk produk KLEP SET HGLPRO NEOTECH untuk bulan Januari 2019 adalah sebanyak 24. Sedangakan untuk validasi hasil peramalan diperoleh nilai Mean Absolute Deviation sebesar 4.11 dan nilai tracking signal -0.81 artinya nilai data aktual permintaan lebih kecil dari nilai hasil peramalan, ditunjukkan dengan nilai negatif. Sehingga disimpulkan bahwa sistem peramalan ini telah teruji dengan data dan diperoleh nilai ramalan yang baik.
Strategi Recovery Plan Teknologi Informasi di Perguruan Tinggi Menggunakan Framework NIST SP 800-34
Authors: Suhartono Didit , Isnaini Khairunnisak Nur
Published: September 2021

Suatu organisasi memerlukan sumber daya yang memadai dan mendukung, seperti informasi yang harus dijaga serta dilindungi dari berbagai macam bencana maupun ancaman. Ancaman yang menyerang suatu sistem pun masih banyak terjadi khususnya pada sistem yang krusial. Risiko-risiko yang dapat terjadi adalah kerusakan fisik dari server maupun gangguan jaringan sehingga membutuhkan rancangan penanganan bencana menggunakan DRP. Perencanaan pemulihan risiko atau disebut sebagai Disaster Recovery Planning (DRP) merupakan mekanisme atau sebuah perencanaan yang dilakukan sebagai pemulihan dari bencana yang terjadi. Strategi Recovery Plan dibuat berdasarkan kerangka kerja NIST (National Institute of Standard and Technology) SP 800-34 terdiri dari Risk Assesment, Business Impact Analysis (BIA), Recovery Strategy, Testing, dan Plan Documentation. Hasil yang diperoleh dari penelitian ini menunjukan dokumen Disaster Recovery Plan dapat membantu memulihkan sistem informasi apabila terjadi suatu bencana berdasarkan tingkat prioritas risiko dampak yang terjadi. Urutan tingkat prioritasnya antara lain Website Student dengan nilai 100% dan masing-masing 67% untuk E-Learning; Absensi Perkuliahan; dan Smart Dosen.
Analisis Website Program Kreativitas Mahasiswa (PKM Center) Universitas Ahmad Dahlan Menggunakan WebQual 4.0
Authors: Yulianto Dinan , Ismail Taufiq
Published: September 2021

Dewasa ini, pihak individu dan organisasi telah memanfaatkan media website sebagai teknologi informasi untuk membagikan atau mendapatkan informasi secara mudah dalam waktu singkat. PKM Center Universitas Ahmad Dahlan telah menggunakan media website sebagai pelayanan lomba setiap mahasiswa, tetapi mendapatkan sejumlah masukan dari pengguna terkait tampilan website yang kurang atraktif, dan informasi yang disampaikan kurang aktual. Penelitian ini bertujuan untuk menganalisis website PKM Center Universitas Ahmad Dahlan berdasarkan persepsi pengguna melalui pendekatan WebQual 4.0. Proses analisis diawali dengan menyusun hipotesis penelitian untuk mengkaji antara hubungan variabel independen yang terdiri dari kegunaan, kualitas informasi, dan kualitas layanan interaksi terhadap variabel dependen yaitu kepuasan pengguna. Proses kedua adalah menyusun, dan menguji instrumen penelitian melalui uji validitas dan uji reliabilitas oleh 30 mahasiswa. Proses ketiga adalah mendapatkan data primer melalui penyebaran instrumen kepada 130 mahasiswa. Proses terakhir adalah mengkaji hasil interpretasi responden melalui uji normalitas, uji korelasi uji-t, dan uji-f untuk pembuktian hipotesis penelitian. Hasil penelitian menunjukkan bahwa setiap variabel independen secara parsial maupun simultan berkorelasi, dan berhubungan kuat terhadap variabel dependen.
Ekstraksi Pengetahuan pada Penurunan Minat Mahasiswa Mengikuti Bursa Kerja Menggunakan Soft System Methodology
Authors: Lattu Arny , Manongga Danny , Iriani Ade
Published: September 2021

Mendapatkan pekerjaan sesuai dengan bakat dan minat adalah goal yang ingin dicapai oleh mahasiswa Fakultas Teknologi Informasi di Universitas X setelah lulus. Namun ternyata hal ini bukanlah mudah karena lapangan pekerjaan yang tersedia tidak sebanding dengan jumlah mahasiswa yang ingin segera bekerja setelah lulus. Mengatasi hal ini, Unit Pengembangan Karir dan Alumi Universitas X melakukan kegiatan bursa kerja yang dilakukan sebanyak 3 kali mengikuti periode wisuda di Univeritas X. Tujuan dari kegiatan ini adalah mempercepat mahasiswa mendapatkan pekerjaan sesuai bakat dan minatnya. Dengan adanya pelaksanaan kegiatan bursa kerja yang terorganisir dengan baik tentu menarik minat dari mahasiswa untuk turut serta dalam kegiatan ini. Masalah yang muncul ketika terjadinya penurunan minat mahasiswa dalam mengikuti bursa kerja yang disebabkan oleh faktor-faktor yang belum dapat diidentifikasi. Untuk itu, perlu diterapkan sebuah metode yang dapat mengekstraksi faktor-faktor dibalik terjadinya penurunan tersebut yaitu Soft System Methodology. Penelitian ini menggunakan SSM untuk mendeskripsikan masalah penyebab penurunan minat mahasiswa yang belum terdefenisi dengan baik. Fokus penelitian ini adalah mahasiswa Fakultas Teknologi Informasi Universitas X. Pengumpulan data dilakukan dengan observasi dan teknik wawancara. Setelah mendapatkan pengetahuan tersebut, hasil dari penelitian ini adalah sebuah model konseptual yang berisi elemen-elemen yang diperlukan dalam mengurangi penurunan minat dan tindakan perbaikan terhadap situasi permasalahan yang dihadapi bursa kerja serta model sistem informasi Evaluasi Bursa Kerja
Rapid Application Development untuk Sistem Informasi Payroll berbasis Web
Authors: Saraswati Ni Wayan Sumartini , Wardani Ni Wayan , Maswari Ketut Laksmi , Muku I Dewa Made Krishna
Published: September 2021

Pertambahan jumlah karyawan Sekolah Tinggi Manajemen Informatika dan Komputer / STMIK STIKOM Indonesia disertai dengan segala perubahan data di dalamnya menyebabkan perlu usaha ekstra dalam menyusun daftar gaji tiap bulannya. Adanya sistem informasi penggajian diyakini dapat membuat penyusunan daftar gaji menjadi lebih efektif dan efisien. dalam penelitian ini dilakukan pengembangan sistem informasi payroll berbasis website yang sesuai dengan proses bisnis di STMIK STIKOM Indonesia. Metode pengembangan perangkat lunak Rapid Application Development / RAD dipilih karena metode ini cocok dengan target waktu pengembangan aplikasi yang singkat. Berdasarkan pengujian fungsionalitas sistem menggunakan metode blackbox testing diperoleh kesimpulan bahwa sistem yang dikembangkan telah mampu memenuhi kebutuhan fungsional sistem dengan baik.
Therapeutic Interior & its Effects on Patients
Authors: Marwah Anjali
Published: September 2021

The interior of the room is influenced by user perceptions of psychological security, closeness, self-disclosure, the ability to form therapeutic connections, and the feeling of the Persons in the environment. Poor treatment spatial design may increase emotions of otherness, hinder agency development, restrict communication, and result in poor service user outcomes and experiences. In this paper, we have discussed the influence of interior design of clinic or home space on therapeutic process. Architectural elements are the generally permanent components of an environment in which a clinic or the house is located such as the physical design, design, size and form of the furniture, closets or other equipment, and the materials used in its construction. Low lighting may have a pleasant and calming impact on an individual’s perceived attraction and customer self-disclosure. The findings show that the interior design of the counselling room may have an impact on communication and other human interactions. The environment of the room may also influence communication. Sommer (1969) found that the discussion of female geriatric participants rose in a pleasant or socio-fugal setting, including flowers, magazines, vase and others. From a practical point of view, knowing environmental variables in advice like lighting effects enables advisors more effectively to undertake therapy. We see counselling contexts as overlapping areas, as do other scholars. The connection between environmental and clinical psychology should be made clear to counsellors, clinicians, psychiatrists and their organisations. They are more conscious of environmental effects throughout their treatment sessions.
Elucidating the Role of Nrf2 Factor Interactions in Various Disorders of Human System and It’s Proteomic Approaches: A Novel Study
Authors: Chakraborty Aparajita
Published: September 2021

Nuclear factor erythroid 2-related factor 2 (Nrf2), which is also known as nuclear factor erythroid-derived-like-2, is a transcription factor which is encoded by the NFE2L2 gene. It is a basic leucine zipper (bZIP) protein which coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes. It modulates a cellular antioxidant response program and plays a major role in the protection against oxidants and electrophiles; extracellular and intracellular oxidant/electrophiles have great contributions to the damages in cellular macromolecules such as proteins, lipids or DNA. Keap1 protein which is a regulator of Nrf2, is a highly redox-sensitive member of BTB-Kelch family assembling with Cul3 protein to form a Cullin-RING E3 ligase complex for Nrf2 degradation. Thus, this factor is a regulator of many processes of life and it’s signalling system (Nrf2-KEAP-1-ARE pathway) has been found to participate in various ocular or eye diseases and even other systemic diseases such as respiratory disease, chronic diseases or cancer. In microbial infections, the host oxidative stress response may lead to the production of cytoprotective molecules, which in turn induces the activation of cellular Nrf2 factor. The crystallins or eye lens proteins, (?B-crystallin being one of them) may possibly interact with Nrf2 factor and regulate oxidative stress, but it is yet to be deciphered. Proteomic studies may provide valuable information, regarding such detailed protein interactions and their pathways especially in case of diseases or infections in the upcoming days.
Effect of Nicotine Administration on Body Weight and Liver Enzymes in Male Rats
Authors: Johni Faraj Hato
Published: September 2021

The study was conducted in Basrah University – veterinary medicine college, used about (60) sixty male rats divided into two groups randomly, control group and nicotine treated group with 0.5 mg / kg / BW, the result showed no significant difference in growth rats compared to control group also significant increase of liver enzymes compared to the control groups.
PARVG expression associates with survival in triple negative breast cancer.
Authors: Mamoor Shahan
Published: September 2021

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival at time of analysis: dead or alive. We observed significant transcriptome-wide differential expression of parvin, gamma, encoded by PARVG when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, PARVG expression was significantly correlated with overall survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. PARVG may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.
Extending Maternity Leave and Early Childhood Health in Zimbabwe
Authors: Le Kien
Published: September 2021

This paper explores the relationship between extending maternity leave and child health. To quantify the relationship of interest, we exploit the expansion of maternity leave in Zimbabwe Labour Amendment Act of 2005 that went into effect in December 2005. We find statistical evidence on the positive association between extending maternity leave and child health. Quantitatively, those exposed to the maternity leave extension grow 0.522 standard dеviations taller for their age, weigh 0.959 standard dеviations more for their age, and weigh 0.580 standard dеviations more for their height. The findings emphasize the significance of increasing maternity leave in enhancing child health.
PCGF2 expression associates with survival in triple negative breast cancer.
Authors: Mamoor Shahan
Published: September 2021

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival at time of analysis: dead or alive. We observed significant transcriptome-wide differential expression of polycomb group ring finger 2, encoded by PCGF2 when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, PCGF2 expression was significantly correlated with distant metastasis-free survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. PCGF2 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.
lcsm: An R package and tutorial on latent change score modelling
Authors: Wiedemann Milan , Thew Graham R , Košir Urška , Ehlers Anke
Published: September 2021

Latent change score models (LCSMs) are used across disciplines in behavioural sciences to study how constructs change over time. LCSMs can be used to estimate the trajectory of one construct (univariate) and allow the investigation of how changes between two constructs (bivariate) are associated with each other over time. This paper introduces the R package lcsm, a tool that aims to help users understand, analyse, and visualise different latent change score models. The lcsm package provides functions to generate model syntax for basic univariate and bivariate latent change score models with different model specifications. It is also possible to visualise different model specifications in simplified path diagrams. An interactive application illustrates the main functions of the package and demonstrates how the model syntax and path diagrams change based on different model specifications. This R package aims to increase the transparency of reporting analyses and to provide an additional resource to learn latent change score modelling.
PRINCÍPIOS DA PSICOLOGIA DA GESTALT APLICADOS NA ANÁLISE DE COESÃO E COERÊNCIA TEXTUAIS
Authors: SIQUEIRA KATIA
Published: September 2021

O presente texto pretende, numa abordagem cognitiva dos processos intra e inter- subjetivos, tomando por base os princípios que a Psicologia da Gestalt propõe como organizadores da percepção, analisar as características de coesão e coerência do texto escrito, compreendendo que estas são fatores organizadores da percepção do sentido comunicado pelo texto. Uma vez que o objeto desta pesquisa é o texto, interessa, de início, que sejam analisados seus aspectos, visando ampliar sua compreensão na construção da abordagem cognitiva.
Effect of swearing on strength: Disinhibition as a potential mediator
Authors: Stephens Richard , Dowber Harry , Barrie Amber , Almeida Sannida , Atkins Katie
Published: September 2021

Introduction: Swearing fulfils positive functions including benefitting pain relief and physical strength. Here we present three experiments assessing a possible psychological mechanism, increased state disinhibition, for the effect of swearing on physical strength. Method: Three repeated measures experiments were carried out with sample sizes N=56, N=63 and N=118. All three included the Balloon Analogue Risk Task (BART) to measure risky behaviour. Experiments 1 and 3 included measures of physical performance assessing, respectively, grip and arm strength. Experiment 3, which was pre-registered, additionally assessed flow, self-confidence, anxiety, emotion including humour, and distraction including novelty.Results: Experiments 1 and 3 found that repeating a swear word benefitted physical strength and increased risky behaviour, but risky behaviour did not mediate the strength effect. Experiment 2 showed no effect of listening to an audio track of a repeated swear word. Experiment 3 found that repeating a swear word increased flow, self-confidence, positive emotion, humour and distraction. Humour mediated the effect of swearing on physical strength. Discussion: Consistent effects of swearing on physical strength indicate that this is a reliable effect. Swearing affected several constructs related to state disinhibition including increased self-confidence. Humour appeared to mediate the effect of swearing on physical strength, consistent with a hot cognitions explanation of swearing-induced state disinhibition. However, as this mediation effect was part of an exploratory analysis, further pre-registered experimental research including validated measures of humour is required.
Pandemic and student mental health: A cross-sectional and longitudinal analysis of mental health symptoms amongst university students and young adults after the first cycle of lockdown in the UK
Authors: Tang Nicole , McEnery Katharine , Chandler Laura , Toro Carla , Walasek Lukasz , Friend Hannah , Gu Sai , Singh Swaran P , Meyer Caroline
Published: September 2021

Background Early COVID-19 research suggests a detrimental impact of the initial lockdown on young people’s mental health.AimsWe investigated mental health amongst university students and young adults after the first UK lockdown and changes in symptoms over 6 months. Method 895 university students and 547 young adults not in higher education completed an online survey at T1 (July-September 2020). A subset of 201 university students also completed a 6-month follow-up survey at T2 (January-March 2021). Anxiety, depression, insomnia, substance misuse and suicide risk were assessed. ResultsAt T1, ~40%, 25% and 33% of the participants reported moderate-severe anxiety and depression and substance misuse risk; clinically significant insomnia; and suicidal risk. Reduction in anxiety and depression were observed in participants reassessed at T2, but not in insomnia, substance misuse and suicidality. Student and non-student participants reported similar levels of mental health symptoms. Student status was not a significant marker of mental health symptoms, except for lower substance misuse risk.Cross-sectionally, greater symptoms across measures were consistently associated with younger age, pre-existing mental health condition(s), being a carer, worse-off financial status, increased sleep irregularity and difficulty since lockdown. Longitudinally, T2 symptoms were consistently associated with worse-off financial status and increased difficulty sleeping at T1. These associations however attenuated when baseline mental health symptoms were adjusted for in the models. Conclusions Mental health symptoms were prevalent in a large proportion of young people after the first UK lockdown. Risk factors identified may help characterise high-risk groups for enhanced support and inform interventions.
Protective effect of Mollugo cerviana extract on liver markers in alloxan induced diabetic rats
Authors: Markkas N. , Govindharajalu Madhuramozhi
Published: September 2021

Diabetes mellitus is a metabolic disorder of multiple aetiology characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. Liver is the central metabolic organ in body responsible for glucose homeostasis, diabetes leads to hepatic dysfunction. In the present study to investigate the protective effect of Mollugo cerviana extract on liver markers in alloxan induced diabetic rats. Hepatospecific enzymes (ALP, ALT and AST), protein and albumin content were activated when hepatocellular damage gave rise to abnormalities of liver function and these enzymes are remarkably increased in diabetic rats. Further confirmed in the histopathological studies of liver. Mollugo cerviana helps in parenchymal cell regeneration in liver, thus protecting membrane integrity and thereby minimizing enzyme leakage. Histopathological studies also supported the biochemical parameters. This result suggested that Mollugo cerviana possess potential hepato regenerating activity.
Sedative activity of ethanolic and aqueous extracts of Euphorbia hirta
Authors: Venkatachalam Dhanapal , B Samuel Thavamani , Kumar Sampath
Published: September 2021

Insomnia is persistent difficulty in falling asleep that affects regular day time activities. It can induce significant psychological and physical disorder. Insomnia is treated pharmacologically and nonpharmacologically or by a combination of both. Relaxation, sleep restriction, stimulus control and sleep hygiene are known behavioural therapies for insomnia. Modern studies have shown that herbal drugs exert good sedative and hypnotic effect on the central nervous system. One such medicinal plants is Euphorbia hirta.. E. hirta belongs to the plant family Euphorbiaceae and genus Euphorbia. The leaf of Euphorbia hirta have several therapeutic applications in folk medicine in curing or managing wide range of diseases including insomnia. In the present study ethanol and aqueous extract of leaf Euphorbia ssssshirta was evaluated for sedative activity using phenobarbiton–induced sleep model in rat. Aqueous and ethanolic extracts (100mg/kg and 200 mg/kg) produced significant onset of sleep and duration of sleep (p<0.01). These results suggest that the fractions of aqueous and ethanolic extracts obtained from the leaf of Euphorbia hirta possess sedative activity.
Ethnomedicinal, Pharmacological and Antimicrobial Aspects of Moringa oleifera Lam.: A review
Authors: Singh Ajeet , Navneet Dr.
Published: September 2021

The inclusive information is provided in present review on traditional uses, antimicrobial activity and pharmacology of Moringa oleifera Lam. It is commonly known as ‘drumstick tree’. M. oleifera is alternative tonic, astringent, emollient, aphrodisiac etc. Bark of this plant is considered as cooling. Seeds of this plant are considered as aphoradisiac. It has a depressant rather than a stimulant effect on the central nervous system. Many pharmacological investigations have been carried out based on its chemical constituents. Extensive literature survey revealed many pharmacological properties includes antibacterial, antifungal, anticancer, anticonvulsant, antidiabetic, antimutagenic, anticlastogenic, anti-fertility, antiulcer, antioxidant, antiviral and wound healing activities.
Antioxidant and anticancer activities of an Aporphine alkaloid isolated from Alphonsea sclerocarpa
Authors: DSD Suman Joshi , Amgoth Chander , S Surya Narayana , CH Padmavathi , Madhavi J , A Krishna Satya
Published: September 2021

Herein, we report on the anticancer and antioxidant activity of an Aporphine alkaloid isolated from medicinal plant Alphonsea sclerocarpa. Conventional column chromatography and preparative HPLC methods were used to isolate and purify the alkaloid. Based on NMR, FTIR and MS/MS spectroscopic techniques the compound was identified as Crebanine. This is the first report on the presence of Crebanine from the leaves of Alphonsea sclerocarpa. Antioxidant activity was evaluated using DPPH and FRAP assay. The antioxidant activity was dose-dependent and activity increased with the increase in the concentration. The cytotoxicity assay was carried out using MTT assay. The results showed remarkable cytotoxic activity against K562 (CML-chronic myeloid Leukaemia blood cancer) cells with a % inhibition of 37.545 at 500µm concentration after an incubation of 24h.
Resultados comparativos de la prueba saber 11 antes y durante la pandemia por COVID-19 en una institución educativa de Soacha, Cundinamarca, Colombia
Authors: Díaz Pinzón Jorge Enrique
Published: September 2021

Introducción: la afección por coronavirus 2019 (COVID-19) es una enfermedad respiratoria aguda infecciosa CAUSADA por un nuevo coronavirus. La Organización Mundial de la Salud (OMS) fue conocedora de casos de neumonía de etiología microbiana irreconocible, asociados con la ciudad de Wuhan, provincia de Hubei, China, el 31 de diciembre 2019. Objetivo: comparar los resultados de las pruebas Saber 11- 2019 y 11- 2020 durante la pandemia del COVID-19 en la institución educativa General Santander del municipio de Soacha, Cundinamarca, Colombia. Metodología: trabajo de tipo experimental, la información se obtuvo de los resultados de las pruebas Saber 11, 2019 y 2020.  Resultados: los promedios en las diferentes asignaturas evaluadas en la prueba no tuvieron diferencias significativas, es decir que no se evidenció una disminución en el resultado global de la prueba en dicha institución. Conclusión: el hecho de que no haya diferencias significativas entre los años 2019 y 2020 radica también en que los estudiantes pertenecen al mismo contexto social y económico.
Teaching in the Subject “Systems Interconnection” at Extremadura University
Authors: Masa Juan Arias , Espada Rafael Martín , Abelaria Juan Arias
Published: September 2021

This work describes the teaching that is used in the subject of "Systems Interconnection" that is taught in the Higher Telecommunications Engineering of the University of Extremadura. Each of the sections that make up the subject are detailed, both the competences that the students will have as soon as they pass the subject, as well as the theoretical and practical contents taught therein. In addition, a summary is made of the teaching methodology used, the learning results, and finally ends detailing the evaluation methodology  and above of all the academic results of the last courses, where an improvement in these results is observed, especially in the percentage of approved by reducing the sum of the percentages of unchanged and suspended.
Utjecaj nošenja medicinske ili pamučne zaštitne maske na vokalni zamor učitelja i nastavnika
Authors: Malešević Ema , Boljkovac Andrea , Križanić Lana , Ilić Martina , Kršulja Roberta , Glučina Marta
Published: September 2021

Cilj ovog istraživanja je, primjenom kratkog upitnika samoprocjene, istražiti utječe li nošenje medicinske ili platnene zaštitne maske tijekom nastave na vokalni zamor učitelja razredne (N=102) i učitelja ili nastavnika predmetne nastave (N=398). Rezultati upitnika uspoređeni su u odnosu na prijašnju prisutnost poremećaja glasa, razrednu i predmetnu nastavu, te dob sudionika. Potvrđene su statistički značajne razlike u svim varijablama, osim jedne, između skupine sudionika koji su prije obveznog nošenja zaštitnih maski na nastavi imali poremećaj glasa i onih koji nisu imali. Razlika između predavača razredne i predmetne nastave, pokazala se statistički značajnom samo u varijabli koja se odnosi na osjećaj lošije kvalitete glasa nakon nošenja zaštitne maske.
Vocal therapy for transgender people
Authors: Marijan Katarina , Bonetti Ana
Published: September 2021

Transgender people can engage in a number of procedures to deal with the incongruence between their physical gender and the one with which they identify. One of the experts involved in the process of gender transition is a speech-language pathologist (SLP), whose role is to collaborate with the client on the goal to develop vocal, language and communication behaviors that match the desired gender identity. This case report presents one such collaboration, which included voice and communication therapy for a male-to-female transgender person aimed at the voice feminization.
Uloga logopeda u neurogenoj disfagiji
Authors: Pilepić Lara , Roje Bedeković Marina
Published: September 2021

Neurogene orofaringealne disfagije su vrlo čest simptom i posljedica akutnih i kroničnih neuroloških bolesti, posebice cerebrovaskularnih, ekstrapiramidnih i demijelinizacijskih bolesti. Poremećaj gutanja uzrokuje niz sekundarnih komplikacija - malnutriciju, dehidraciju i aspiracijsku pneumoniju - ali i one suptilnije, često nedovoljno osviještene, psihološke i socijalne posljedice koje dugoročno utječu na kvalitetu života bolesnika. Prepoznavanje i liječenje bolesnika s poremećajem gutanja nerijetko je izazov, zato se cjelokupan postupak odvija u okviru multidisciplinarnog tima. Klinički logoped je sastavni dio multidisciplinarnog tima koji dijagnosticira i liječi poremećaje gutanja, svojim znanjem i kompetencijama utječe na povoljan rezultat liječenja. Logoped, kao član multidisciplinarnog tima, prilagođava konzistenciju hrane koju će uzimati bolesnik s neurogenom disfagijom i omogućuje sigurno hranjenje terapijskim postupcima. Logoped inicijalno provodi testove procjene gutanja, kojima prepoznaje bolesnike s rizičnim čimbenicima za aspiraciju. Ako je kod bolesnika uočen nesiguran obrazac gutanja, provodi se detaljna logopedska dijagnostika kojom se utvrđuje dalji način prehrane, kako bi se bolesniku omogućilo sigurno gutanje. Logoped odabire jednu ili više rehabilitacijskih tehnika koje će primijeniti, ovisno o bolesnikovu općem zdravstvenom stanju, suradljivosti i mogućnosti korištenja naučenim tehnikama nakon otpusta iz bolnice. Ovaj rad daje uvid u načine na koje se logoped brine o bolesnicima s poremećajem gutanja – od primitka do otpusta iz bolnice – i naglašava važnost logopeda u multidisciplinarnom timu, koji se bavi neurogenom disfagijom.
Вплив тембрових детермінант оркестрового твору на його переклад для двох баянів
Authors: Бєдний Сергій
Published: September 2021

Проаналізовано сутність поняття «тембр» та технологію його утворення оркестровими інструментами та сучасним баяном. Розглянуто вплив тембрових детермінант оркестрового твору на його переклад для двох баянів. Обґрунтовано зміст модальних та інтенсивних властивостей тембрового звучання як оркестрових інструментів, так і двох баянів, які транслюються звуковими хвилями в просторі та часі. З’ясовано, що для досягнення максимальної імітаційної тотожності звучання двох баянів звучанню оркестрових інструментів автору перекладу необхідно враховувати «темброву вертикаль», «темброву горизонталь» та «темброву діагональ» оркестрового твору. Визначено алгоритм створення перекладу оркестрового твору для двох баянів, який складається зі сприйняття первинного музичного образу (звучання оркестрових інструментів) та уявного зіставлення з вторинним музичним образом (звучання двох баянів) на перцептивно-когнітивному рівні митця. Описано кожну «операцію» цього алгоритму, яка відбувається завдяки асоціативному ланцюжковому принципу і супроводжується пошуком уявних інваріантів перекладу оркестрового твору для двох баянів. Встановлено, що у процесі зіставлення первинних і вторинних музичних образів характеристики тембрових звукових хвиль від трансляції оркестрових інструментів залишаються незмінними, а інформація репрезентована з довгострокової пам’яті автора перекладу оркестрового твору для двох баянів — набуває рис варіативності. Висвітлено технологію пошуку найпривабливішого варіанту перекладу оркестрового твору для двох баянів. Описано методи досягнення насиченості тембрового звучання двох баянів аналогічної оркестровим інструментам. Продемонстровано приклади досягнення максимальної імітаційної тотожності тембрового звучання двох баянів тембровому звучанню оркестрових інструментів на основі сприйняття обертонів звучання оркестрових інструментів і їх трансформації у звучанні двох баянів