bluuebunny/crossref_metadata_2025 huggingface dataset:
Tipos humanos, mito e identidad individual en el alma matinal de Jose Carlos Mariátegui
Authors: Nugent José Guillermo
Published: May 2023

Esta recopilación comprende artículos publicados entre octubre de 1924 y noviembre de 1925 con algunas importantes excepciones: "Roma y el artegótico", un texo que anteriormente no había llegado a publicar y de suma importanciapara apreciar las tendencias autobiográficas del autor; "El Alma Matinal", artículo de febrero de 1928; "El problema de las élites" de enero de ese año; "Esquema de una interpretación de Chaplin"; una serie de artículos sobrePiero Gobetti de julio de 1929; "La influencia de Italia en la cultura hispanoamericana de agosto de 1928; y reseñas sobre Bemard Shaw, Waldo Frank, James Joyce. "El Cementon de Gladkov y la "Novela revolucionaria" alemana, publicados todos entre 1926 y 1929. De todos modos, se trata de un conjunto incompleto pues Mariátegui había incluido en el plan de la obra un capítulo llamado "apología del aventurero" que no llegó a escribir y que estaba destinado a ser una semblanza de Cristóbal Colón.
Pobreza, desarrollo y violencia agraria en el Perú
Authors: Valcárcel Marcel
Published: May 2023

En este artículo se persigue efectuar una síntesis de cómo en diversos trabajos, desde las ciencias sociales, se ha interpretado el origen y naturaleza de la pobreza, la violencia y el atraso agrario en nuestro país. Así como, y amanera de conclusión, bosquejar lo que para crecientes grupos y sectores socialesa parece como una vía hacia el encuentro con la paz y el desarrollo.
Amazonia: indígenas, campesinos y proletarios
Authors: Rodríguez Martha
Published: May 2023

No presenta resumen
Liderazgo femenino y violencia en el Perú de los 90
Authors: Barrig Maruja
Published: May 2023

No presenta resumen
Sobre la categoría género: una introducción teórico-metodológica
Authors: Barbieri Teresita De
Published: May 2023

No presenta resumen
Individuo, sociedad, sociología
Authors: Germaná César
Published: May 2023

No presenta resumen
Del pesimismo sociológico y de su posible disolución
Authors: Grompone Romeo
Published: May 2023

No presenta resumen
Del vecindario a las redes sociales: cambio de perspectivas en la sociología urbana
Authors: Panfichi Aldo
Published: May 2023

No presenta resumen
La sociología como ciencia y como profesión
Authors: Germaná César
Published: May 2023

No presenta resumen
Elementos de una aproximación interpretativa a las Ciencias Sociales
Authors: Kahhat Farid
Published: May 2023

No presenta resumen
Discursos, identidades y la invención histórica de la clase media peruana
Authors: Parker David
Published: May 2023

No presenta resumen
¿Progresando hacia qué? La noción de progreso científico en la ciencia como una vocación de Weber
Authors: Kahhat Farid
Published: May 2023

No presenta resumen
Violencia política y aprobación presidencial en el Perú
Authors: Arce Moisés
Published: May 2023

No presenta resumen
Sociedad civil, esfera pública y democratización en América Latina: Andes y Cono Sur.
Authors: Dargent Eduardo
Published: May 2023

No presenta resumen
La lucha por nominar: los significados de «lo andino» en la narrativa peruana contemporánea
Authors: Manky Omar
Published: May 2023

El artículo argumenta que actualmente existe un proceso de construcción de «lo andino» como tradición literaria. Sin embargo este proceso no obedece a una sola lógica, aunque la mayoría de escritores denominados «andinos» busquen aparecer como un colectivo homogéneo y con intereses comunes. Por el contrario, aquí se da cuenta de tres lógicas de construcción literaria: la popular, la indigenista y la ‘heterogénea’. Estas son examinadas desde el Análisis Crítico del Discurso, tomando como ejes la manera como cada una busca diferenciarse de «los otros»: la «literatura criolla» y la «literatura indigenista». Se intenta ubicar esta toma de posición no solo al interior de tradiciones literarias específicas, sino también contextualizarlas a partir de algunos de los cambios ocurridos en el Perú durante los últimos treinta años
A propósito de pertenecer y ser un@ mism@: jóvenes, experiencias organizativas, autonomías personales y posibilidades para la ciudadanía en villa el salvador
Authors: Duárez Jorge Luis
Published: May 2023

El presente trabajo pretende analizar los impactos que han tenido la individualización de los jóvenes de Villa El Salvador en sus experiencias de participación en organizaciones sociales. Sostengo que estos impactos estarían caracterizados porcomplejas interrelaciones entre lo organizativo y lo individual, caracterizadas estas por mayores oportunidades para el desarrollo de formas identitarias societarias. Estas formas identitarias a su vez estarían permitiendo la promoción de la ciudadanía civil, la cual en décadas pasadas era relegada por la ciudadanía social.
En torno a la representación especial indígena en el Perú: percepción de líderes indígenas y características del modelo peruano
Authors: Villanueva Montalvo Aída
Published: May 2023

Se aborda la representación especial o descriptiva de poblaciones indígenas en espacios formales de decisión, con foco en el ámbito parlamentario y en la potencialidad de un diseño en esta línea para el caso peruano. Como marco, el trabajo reseña los beneficios asociados a la representación descriptiva de minorías, así como dos casos de interés: México y Nueva Zelanda. Se presenta la opinión sobre este tema de líderes indígenas peruanos, cuyos testimonios fueron recogidos durante el verano de 2009. El texto incluye una breve descripción del marco normativo peruano, como también una mirada a la magnitud de la representación indígena reciente en el Parlamento. La última sección presenta notas a modo de conclusión, y una reseña sucinta de algunas estrategias ensayadas para incluir a poblaciones indígenas en espacios formales de poder.
¿Construyendo una masculinidad «alternativa» desde la escuela peruana? Una aproximación a la socialización masculina del joven en un colegio limeño de orientación alternativa
Authors: Rondán Vásquez Luis
Published: May 2023

Esta investigación busca conocer las formas masculinas de actuar que construyen los alumnos en ámbitos educativos donde es más probable que se cuestione el modelo de masculinidad tradicional (MMT, por sus siglas), que caracteriza al varón como un ser diferente y superior que la mujer. Estudiamosun colegio privado, laico, mixto y de orientación «alternativa» (caracterizada por promover valores democráticos), porque investigaciones previas muestran indicios de que estos colegios pueden cuestionar activamente estereotipos de género. Encontramos que las formas masculinas de actuar que los alumnos construyen reproducen de forma parcial y problemática el MMT. Las medidas tomadas por el colegio para promover la equidad de género propiciaron que los alumnos asumieran algunas prácticas distanciadas del MMT (en aspectos como la expresividad emocional), pero son insuficientes para garantizar que no se reproduzcan otros aspectos del MMT (como la tendencia al dominio o el rechazo a los gais).
Health Workforce Interventions in Low-and-Middle-Income-Countries (LMICs)
Authors: Hicks Jacqueline
Published: May 2023

The clearest overall message from across the literature is that designing human resources for health (HRH) initiatives should begin by understanding the needs of a health system or population rather than choosing a specific strategy. In other words, there are no strategies that are universally effective, only strategies that are more or less appropriate to their context. One group of experienced researchers note the “difficulty in predicting how effective a strategy will be in a given context” (Rowe et al, 2018b). Another states that “in 2006, the World Health Report observed that a ‘solution is not straightforward, and there is no consensus on how to proceed.’ This observation remains true in 2020” (Kerry et al., 2020, p.1). The appetite for evidence-based solutions to the health workforce crisis in low-and-middle-income-countries (LMICs) has driven a large research effort to compare different strategies across multiple contexts. The most comprehensive to date, the Health Care Provider Performance Review (HCPPR), offers some findings, but the authors themselves are tentative in their recommendations given the methodological complexity of the research task.
A case with prenatal molecular diagnosis of X-linked transient antenatal Bartter syndrome
Authors: Xu Ke , Zhang Yanqin , Hou Xinlin , Yang Huixia , Ding Jie , Wang Fang
Published: May 2023

Early-onset polyhydramnios during pregnancy can be caused by X-linked transient antenatal Bartter syndrome. Most of the reported cases were molecularly diagnosed after birth, whereas few cases were diagnosed in the fetus period. We received a pregnant woman who had polyhydramnios detected by ultrasound imaging at 25 weeks of gestation, and treated with magnesium sulfate, indomethacin and an amnioreduction at 30 weeks of gestation, whereas amniotic fluid decreased spontaneously since 32 weeks of gestation. Prenatal molecular testing showed the fetus carried MAGED2 hemizygous variant c.967C>T [p. (Asp323*)] inherited from the mother. The preterm boy did not present with polyuria and electrolytes and acid-base imbalance in the early neonatal period, and had good development without polyuria at the age of 20 months. We presented the phenotypes of a Chinese case with a prenatal diagnosis of X-linked transient antenatal Bartter syndrome and his response to prenatal indomethacin treatment. Early identification of the condition helps to provide appropriate prenatal genetic counseling and postnatal management.
Investigation of the Relationship of Gynecological Cancer Awareness with Health Responsibility and Health Literacy
Authors: COŞKUN Sabahat
Published: May 2023

Objective: Women's awareness of gynecological cancers is important for early diagnosis and screening. Health responsibility and health literacy can affect gynecological cancer awareness. Therefore, in this study, it was aimed to examine the relationship between women's gynecological cancer awareness and health responsibility and health literacy.

Methods: The study was designed as cross-sectional. Data were collected from 409 women aged 20-65 working in university units in Turkey between February 2021 and May 2021. In data collection, demographic information, obstetric, gynecologic, and general health characteristics of women, the Gynecological Cancer Awareness Scale (GCAS), the Turkish Health Literacy Scale (THLS-32) and the Health Promoting Lifestyle Profile II/ Health Responsibility Subscale were used. Descriptive, comparative and multiple regression analyzes were conducted.

Results: The total mean score of GCAS was 158.65±16.01 and 8.3% of the participants had insufficient health literacy. A significant regression model, F (df1=14, df2=394) =10.849, p< .001, and 25% of the variance in the dependent variable (R2adjusted = .25) was found to be explained by the independent variables. In the model, the variables that predict and contribute most to women's awareness of gynecological cancer are health responsibility (β= .21, t (394) = 4.35, p< .01), and THLS-32 (β= .20, t(394)= 4.33 , p< .01).

Conclusions: As a result, it is important to consider especially health responsibility and health literacy levels while developing intervention programs for women's awareness of gynecological cancer.
Ultrasound-Based AI for COVID-19 Detection: A Comprehensive Review of Public and Private Lung Ultrasound Datasets and Studies
Authors: Morshed Abrar , Al Shihab Abdulla , Jahin Md Abrar , Al Nahian Md Jaber , Sarker Md Murad Hossain , Ibne Wadud Md Sharjis , Uddin Mohammad Istiaq , Siraji Muntequa Imtiaz , Anjum Nafisa , Shristy Sumiya Rajjab , Rahman Tanvin , Khatun Mahmuda , Dewan Md Rubel , Hossain Mosaddeq , Sultana Razia , Chakma Ripel , Emon Sonet Barua , Islam Towhidul , Hussain Mohammad
Published: May 2023

The COVID-19 pandemic has affected millions of people globally, with respiratory organs being strongly affected in individuals with comorbidities. Medical imaging-based diagnosis and prognosis have become increasingly popular in clinical settings to detect COVID-19 lung infections. Among various medical imaging modalities, ultrasound stands out as low-cost, mobile, and radiation-safe imaging technology. In this comprehensive review, we focus on ultrasound-based AI studies for COVID-19 detection that use public or private lung ultrasound datasets. We surveyed articles that used publicly available lung ultrasound datasets for COVID-19 and reviewed publicly available datasets and organize ultrasound-based AI studies per dataset. We analyzed and tabulated studies in several dimensions, such as data preprocessing, AI models, cross-validation, and evaluation criteria. In total, we reviewed 42 articles, where 28 articles used public datasets, and the rest used private data. Our findings suggest that ultrasound-based AI studies for the detection of COVID-19 have great potential for clinical use, especially for children and pregnant women. Our review also provides a useful summary for future researchers and clinicians who may be interested in the field.
Physico-Chemical Properties and Phosphorus Adsorption Capacity of Ceramsite Made From Alum Sludge
Authors: Shi Li , Zhao Xiaohong , Cao Yongxiang , Ma Hongjuan , Sun Xuejun
Published: May 2023

Alum sludge, an inevitable by-product from the water purification process, which had been applied as substrates in some constructed wetlands with good performance, especially for phosphorus (P) adsorption. The raw alum sludge is like clay lump with irregular shape and has a leaching concern used in the water. For a better reuse, herein, sludge was fired to produce alum sludge ceramsite (ASC) with a uniform spherical shape via four-step process of kneading sludge ball, air drying, preheating at 400°C for 10 min and firing at 600℃ for 5 min. Thereafter the physicochemical properties and P adsorption ability of ceramsite were investigated. Through XRD and FT-IR tests, there was no obvious difference between ASC and air-dried alum sludge ball (adASB) on the phase structure, but a certain amount of Al-OH group loss on the surface of ASC. The structure of ASC was still amorphous as same as adASB, while ASC possessed more micropore structure and bigger specific surface area than those of adASB. Adsorption experiments showed the P adsorption behaviors of ASC and adASB were much similar, and their adsorption kinetics all accorded with the two-step adsorption kinetics rate equation and pseudo-second-order kinetics equation. The maximum adsorption capacities of ASC and adASB fitted by Langmuir model were 1.66 mg/g and 1.89 mg/g respectively. It should be pointed that, compared with other adsorbents, ASC produced in this study still had a higher ability to adsorb P. Therefore, ASC should have a great application potential for P removal in the wastewater treatment in China.
Extended Laplace Power Series Method for Solving Non-linear Caputo Fractional Volterra Integro-differential Equations
Authors: Alomari Abedel-Karrem , Alaroud Mohammad , Tahat Nedal , Almalki And Adel
Published: May 2023

In this paper, we compile the fractional power series method and the Laplace transform to design a new algorithm for solving the fractional Volterra integro-differential equation. For that, we assume the Laplace power series (LPS) solution in terms of power q=1m,m∈Z+, where the fractional derivative of order α=qγ for which γ∈Z+. This assumption will help us to write the integral, the kernel, and the nonhomogeneous terms as a LPS with the same power. The recurrence relations for finding the series coefficients can be constructed using this form. To demonstrate the algorithm's accuracy, the residual error is defined and calculated for several values of the fractional derivative. Two strongly nonlinear examples are discussed to provide the efficiency of the algorithm. The algorithm gains powerful results for this kind of problem. Under Caputo meaning the obtained results are illustrated numerically, and graphically. Geometrically, the behavior of the solution declares that the changing of the fractional derivative parameter values' in their domain alters the style of the attained solution in a symmetrical meaning and fully coinciding to the ordinary derivative value'. From these simulations, the results report that the recommended novel algorithm is a straightforward, accurate, and superb tool to generate analytic-approximate solutions for Integral, and integro-differental equations of fractional order.
Applications of the Microscale Thermophoresis Binding Assay in COVID-19 Research
Authors: Nydegger Damian T. , Pujol-Giménez Jonai , Kandasamy Palanivel , Vogt Bruno , Hediger Matthias A.
Published: May 2023

As the COVID-19 pandemic progresses, new variants of SARS-CoV-2 continue to emerge. This underscores the need to develop optimized tools to study such variants, as well as new coronaviruses that may arise in the future, and to use them for antiviral drug development. Here we introduce microscale thermophoresis (MST) as a reliable and versatile tool for coronavirus research, which we demonstrate through three different applications described in this report: 1) binding of the SARS-CoV-2 spike receptor binding domain (RBD) to peptides as a strategy to prevent virus entry, 2) binding of the RBD to the viral receptor ACE2, and 3) binding of the RBD to ACE2 in complex with the amino acid transporter SLC6A20/SIT1 or its allelic variant rs61731475 (p.Ile529Val). Our results demonstrate that MST is a highly precise approach to study protein-protein and/or protein-ligand interactions in coronavirus research, making it an ideal tool for studying viral variants and developing antiviral agents. The ability to measure interactions with proteins in their near-native plasma membrane environment is a unique advantage of the MST assay over other available binding assays.
Can the Orbital Debris Disease Be Cured Using Lasers?
Authors: Scharring Stefan , Kästel Jürgen
Published: May 2023

Ground-based high-power lasers enable to, in principle, deorbit any kind of space debris object from the low Earth orbit (LEO) by remotely inducing laser-ablative momentum. However, the assessment of efficiency and operational safety depends on many factors like atmospheric constraints or the risk of debris disintegration during irradiation. We analyze laser momentum for a great variety of target geometries and sizes, and – for the first time in a large-scale simulation – include thermal constraints for laser irradiation configuration. Using a coherently coupled 100 kJ laser system at 1030 nm wavelength, 5 ns pulse duration in an optimized pointing elevation angle range, the pulse frequency should amount to less than 10 Hz to prevent fragment meltdown. For mechanically intact payloads or rocket bodies, repetition rates should be even lower. Small debris fragments sized between 10 and 40 cm can be de-orbited by around 100 to 400 station passes with head-on irradiation while objects exceeding 2 m typically require far more than 1000 irradiations for deorbit. Hence, laser-based debris removal cannot be considered a prime space sustainability measure tackling the top-risk large debris, yet it can provide for remediation of a multitude of small-sized debris using small networks of globally distributed laser sites.
The Role of MicroRNA in Plant Response to Abiotic Stress
Authors: Ma Ziming , Hu Lanjuan
Published: May 2023

MicroRNAs (MiRNAs) are a class of non-coding single-stranded RNA molecules of approximately 20-24 nucleotides in plants that play an important regulatory role in a variety of biological processes such as plant growth and development and response to various abiotic stresses. For example Drought, Salt, Cold, High temperature, Heavy metals and Nutrition. MiRNAs affect gene expression by manipulating the cleavage, translational expression or DNA methylation of target mRNAs. This review describes the current progress made on the way miRNAs are produced and regulated and the way miRNA/target gene is used in plant responses to abiotic stresses. Studying the molecular mechanism of action of miRNAs downstream target genes can optimize the genetic manipulation of crop growth and development conditions that provide a more theoretical basis for improving crop production.
ANALYSIS OF SELECTED FUNCTION-DEFINING 2D SURFACE ROUGHNESS PARAMETERS IN TANGENTIAL TURNING
Authors: Sztankovics István
Published: May 2023

Among other, more frequently analysed surface topography parameters, the function-defining parameters must be analysed in different machining procedures to outline their application possibilities. These values are the core roughness, the reduced peak height, the reduced valley depth, the skewness, and the kurtosis of the roughness profiles. Tangential turning is a promising machining procedure, which can produce ground-like surfaces with twist-free properties by defined cutting edged tools. The achievable productivity is also very high. Therefore, in this paper, these roughness parameters were analysed from 2D roughness profiles measured on surfaces machined by tangential turning.
Rice-Body Synovitis, Foreign Body Reaction, and Rotator Cuff Failure After Subacromial Balloon Spacer Augmentation of a Rotator Cuff Repair
Authors: Fury Matthew S. , Cirino Carl M. , White Alex E. , Bauer Thomas W. , Taylor Samuel A.
Published: May 2023

Case:

A 66-year-old woman presented with shoulder pain and weakness 4 months after augmentation of a rotator cuff repair with a Stryker InSpace subacromial balloon spacer. A magnetic resonance imaging (MRI) demonstrated a failed rotator cuff repair, large effusion with rice bodies, synovitis, axillary lymphadenopathy, loose anchors, and erosive changes to the greater tuberosity. Arthroscopy revealed balloon fragmentation surrounded by diffusely hyperemic synovium without repairable cuff tissue. Final cultures proved negative for infection. Histologic evaluation revealed ulcerated synovium with diffuse chronic and focal acute inflammation.

Conclusion:

Despite promising early results, augmentation of a rotator cuff repair with a subacromial balloon spacer introduces a risk of inflammatory reaction that may mimic a deep infection and compromise rotator cuff healing.
ALGORITMA C4.5 UNTUK PREDIKSI BIMBINGAN SISWA BERDASARKAN TIPOLOGI HIPPOCRATES-GALENUS
Authors: Boy Sandy Dwi Nugraha.H  , Defit Sarjon , Widi Nurcahyo Gunadi
Published: May 2023

Jenis kepribadian yang dimiliki seorang siswa diyakini akan mempengaruhi prilakunya baik dalam hal positif atau negatif yang apabila dibiarkan akan merugikan siswa tersebut. Bimbingan siswa perlu dilakukan untuk memberikan arahan yang sesuai untuk siswa tersebut. Penelitian ini bertujuan untuk melakukan prediksi bimbingan  siswa berdasarkan kepribadian dengan menggunakan data siswa di SMP 1 Negeri Tembilahan, proses pengumpulan data didapatkan dari guru BK di SMPN 1 Tembilahan untuk kelas 8 dan kelas 7. Kelas 8 akan digunakan sebagai data latih dan kelas 7 digunakan sebagai data uji. 5 parameter dipilih untuk proses prediksi dan 1 label sebagai kelas target. Metode yang digunakan adalah Alogritma C4.5 untuk membangun pohon keputusan dan mendapatkan rule-rule prediksi, Hasil penelitian dilakukan menggunakan pengujian Confussion Matrix dengan tingkat akurasi prediksi sebesar 70%. Tujuan akhir dari proses prediksi bimbingan siswa adalah hasil prediksi dengan persentasi Ya(perlu bimbingan) lebih besar dari Tidak(tidak perlu bimbingan), maka dapat dinyatakan model proses prediksi dengan Alogtima C4.5 layak digunakan sebagai penentetuan hasil keputusan yang baik dalam hal prediksi dan peneliti berharap setelah mendapatkan hasil tersebut diharapkan pihak Guru BK di SMPN 1 Tembilahan dapat melakukan proses bimbingan secepat mungkin dan memberikan bimbingan yang diperlukan oleh siswa yang membutuhkan.
The Effect of Financial Literacy and Entrepreneurial Motivation on Entrepreneurial Interests
Authors: Utami Reni Putri , Wahyuni Ajeng
Published: May 2023

Financial literacy is an individual's ability and skill in managing personal and business finances, financial literacy is part of entrepreneurship education which is a factor of interest in entrepreneurship. In addition to financial literacy, motivation is also a factor of interest in entrepreneurship. The Faculty of Islamic Economics and Business IAIN Ponorogo is a faculty that has a focus on entrepreneurship development, where the vision and mission, courses and practical activities lead to the development of entrepreneurship. However, the interest in entrepreneurship with the knowledge that has been obtained during college has not been able to arouse interest in entrepreneurship in students. This study aims to examine and analyze the effect of financial literacy and entrepreneurial motivation on student interest in entrepreneurship. This type of research is quantitative research with correlational method, data collection using questionnaires and sampling using proportionate stratified technique with a sample of 96 respondents. Data processing techniques using SPSS 23, and data analysis using multiple linear regression test. The results showed that conventional financial literacy and entrepreneurship motivation had a significant effect on student interest in entrepreneurship, while Islamic financial literacy had no significant effect on entrepreneurial interest. And conventional financial literacy, Islamic financial literacy and entrepreneurship motivation simultaneously affect student interest in entrepreneurship.
Analysis of Internal Control of Merchandise in Edwi Dolopo Store to Improve Business Effectiveness
Authors: Rahmasari Henny , Humaidi Muchtim
Published: May 2023

Internal inventory control is carried out using security measures to avoid theft, errors, or other actions. The existence of an internal control system in the company can create an excellent organizational structure. To create reasonable internal control, the company must fulfill the elements of internal inventory control. In this study, 3 of the 5 elements of internal control were taken, namely internal control procedures for receiving and storing, an organizational structure that strictly separates functional responsibilities and healthy practices in carrying out tasks, and each organizational unit. At Toko Edwi there is a problem with the dual function of receiving and storing functions into one accounting function. The purpose of this study is to find out how the internal control procedures for receiving and storing merchandise inventory at the Edwi Store, how the implementation of internal control over the organizational structure that separates functional responsibilities explicitly on the merchandise inventory at the Edwi shop, how to implement internal control over practices healthy in carrying out the duties and functions of each organizational unit at the Edwi Store. Using qualitative research methods and data collection techniques in the form of interviews, observation, and documentation. The results of this study indicate that Toko Edwi has carried out internal control procedures for proper receipt and storage of merchandise. However, internal control over the organizational structure that separates functional responsibilities has not been strictly implemented. It still concurrently holds the duties of the receiving and storage functions into one accounting function. Internal control of healthy practices in carrying out the duties and functions of each organizational unit is also not appropriately implemented.
Microplastic in Fishes: the First Report From a Himalayan River –alaknanda
Authors: Bhatt Vaishali , Badola Neha , Chauhan Jaspal Singh
Published: May 2023

In the present study, we tried to understand MPs ingestion by five fish species of different feeding habits namely, Schizothorax richardsonii and Crossocheilus latius (herbivore), Cyprinus carpio, Tor chelenoid (omnivore), and Botia horii (carnivore). The fishes were sampled from the patch of the Himalayan river, Alaknanda (one of the headwaters of river Ganges) at Srinagar, Garhwal, Uttarakhand. The fish gut samples were digested, filtered and the number of MPs was then counted microscopically. The results revealed that all the species were contaminated with MPs and the rate of MP ingestion varied with feeding habits. Fish Tor chelenoid, the omnivore, was observed to have maximum MPs. Among the analyzed particles, fibers (66%) were the most dominant type chemically characterized as HDPE, PP, and polyester. This study will contribute as a reference for forthcoming research as it explains the ingestion of MPs by fishes of a Himalayan River.
Lockdowns and Vaccines: Did Covid-19 Interventions Help Reduce the Long-Term Health Economic Consequences in Ghana?
Authors: Crankson Shirley , Mintram Kate , Pokhrel Subhash , Anagnostou Anastasia , Anokye Nana
Published: May 2023

COVID-19 has accounted for over 40,000 job losses and US$35 million in direct management costs in Ghana in 2021 with over 1,400 deaths so far. This study simulated the plausible long-term health economic consequences of COVID-19 and the scale of mitigation that lockdowns and vaccines could offer using the CoronAvirus Lifelong Modelling and Simulation (CALMS) algorithm, a published and fully validated agent-based model. The results showed that a whole population vaccination and periodic lockdown intervention could reduce the long-term COVID-19 infections, mortalities hospitalisations, long COVID and direct healthcare costs by more than 90% in the next ten years in Ghana. Among the simulated interventions, the whole population and periodic lockdown could be the most effective intervention. However, it could be the most expensive intervention (£291 million), followed by lockdowns (£251 million) and vaccinating clinically vulnerable populations (£42,115) at the end of the cohort’s lifetime. A periodic lockdown and whole-population vaccination could be the most effective intervention to reduce Ghana’s long-term COVID-19-related health economics outcomes. Increasing the whole population vaccination target alone could reduce Ghana’s long-term COVID-19 health economics outcomes. Future studies will need to look at wider outcomes (than just the health outcomes) to establish the full cost-benefit of these interventions.
SEATANI: hazards from seamounts in SouthEast Asia, Taiwan, and Andaman and Nicobar Islands (eastern India)
Authors: Verolino Andrea , Wee Su Fen , Jenkins Susanna , Costa Fidel , Switzer Adam
Published: May 2023

Submarine volcanism represents approximately 85% of volcanism taking place on Earth, and submarine eruptions can be particularly hazardous due to their potential to cause large-scale hazards from sector collapses, tsunamis, and ash dispersal. While recent eruptions in the Kingdom of Tonga and Japan have highlighted the significant hazards posed by submarine volcanoes, there has been little to no study of submarine volcanoes in Southeast Asia and its surroundings. Here we present and provide the SEATANI dataset, which compiles a list of 466 seamounts from the region, from different published sources. We characterized them in GIS, based on their shape and inferred evolution stage, which helped us to infer their past hazard history, and identified areas where the hazard posed by submarine volcanic eruptions is likely to be higher, based on exposure analyses. Our results show that there is a large number of potentially hazardous seamounts in this region, and Taiwan had the highest hazard and the highest exposure. Philippines, Indonesia and Vietnam were also found to have relatively high exposure. The results from this work serve as a first step for southeast Asian and neighbouring countries to become more resilient against and prepared for submarine volcanic eruptions in the region.
Efficacy of the Hongjing I granule herbal formulation in treating mild to moderate erectile dysfunction: A multicentre, randomized, double-blind, placebo-controlled clinical trial protocol
Authors: Xu Run-nan , Ma Jian-xiong , Lv Bo-dong
Published: May 2023

Background Erectile dysfunction (ED) is a common disease in male urology, and there is a single class of drugs used for its first-line treatment. Approximately 20% of patients do not experience improvement in overall sexual satisfaction (OS) after taking tadalafil. Currently, traditional Chinese medicine (TCM) is widely used as a complementary and alternative medicine (CAM) approach for ED patients. The Hongjing I granule (HJIG) herbal formula has shown good therapeutic effects on ED in preclinical studies. However, further evidence is needed to demonstrate its clinical efficacy and safety.Methods This study is a randomized, double-blind, placebo-controlled multicentre trial. A total of 100 patients diagnosed with mild to moderate ED caused by qi deficiency and blood stasis will be recruited and randomly assigned to receive one of two treatments: HJIG (N = 50) or placebo (N = 50). Patients will receive 8 weeks of treatment and a 16-week follow-up starting from the fourth week of treatment. Outcome measures, including the International Index of Erectile Function-Erectile Function domain (IIEF-EF) score, Sexual Encounter Profile (SEP), and Traditional Chinese Medicine symptom score, will be evaluated.Discussion This study is the first multicentre study to compare traditional Chinese herbal formulas with placebos in the treatment of ED. It aims to verify the improvement of TCM syndrome differentiation, erectile function, and sexual experience and to further broaden the treatment options for ED. The hypothesis is that HJIG can improve the erectile function score and sexual experiences of patients diagnosed with qi deficiency and blood stasis–type mild to moderate ED. This study may establish a new treatment for ED, distinct from other drugs used for similar clinical indications in clinical practice, and may provide high-quality reference evidence for its use as a complementary or substitute drug.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000041127.
Application of Arc-SWAT model for water budgeting and water resource planning at the Yeralwadi catchment of Khatav, India
Authors: Sabale Ranjeet , Venkatesh B , Jose Mathew
Published: May 2023

Every facet of life, including human habitation, economic development, food security, etc., depends on water as a valuable resource. Due to burgeoning population and rapid urbanization water availability needs to be simulated and measured using hydrologic models and trustworthy data. To fulfill this aim, the SWAT model was processed in this work. The SWAT model was formulated to estimate the hydrological parameters of Yeralwadi using meteorological data from IMD (India Meteorological Department) for a period 1995–2020. The observed discharge data was collected from HDUG Nasik group and used in calibration and validation of Model. The SWAT model was corrected & validated through SUFI-II algorithm in SWAT-CUP to get a better result. The models sensitivity is checked by using statistical parameters like Nash-Sutcliffe Efficiency (NSE) and a coefficient of determination (R2). NSE values were 0.72 and 0.80 in calibration & validation, and R2 were 0.80 & 0.76 in calibration and validation respectively indicating the acceptance of model. Results show that 40.6% of the total yearly precipitation was lost by evapotranspiration. The estimated total discharge from Yeralwadi catchment was 55.6%, out of which 41.2% was surface runoff and 14.4% was baseflow. The other 17.8% was made up of percolation into confined and unconfined aquifers, which served as soil and groundwater storages. The surface runoff is influenced by Curve number (CnII), SOL_AWC, ESCO and base flow was influenced by ALPHA-BF and GW_REVAP. This study will be useful to water managers and researchers to develop the sustainable water resource management and to alleviate the water scarcity issues in study basin.
Bilateral Aspergillus Endophthalmitis Following Cataract Surgery: A Diagnostic and Therapeutic Challenge; Case Report
Authors: Johari Mohammadkarim , Abuali Mostafa , Razavizadegan Seyed Ahmad , Moallem Mehdi
Published: May 2023

Purpose: To describe a case of bilateral Aspergillus endophthalmitis occurring four months after bilateral cataract surgery manifesting as a spectacular filamentary branching on the IOL/capsular surface
Case presentation: A 66-year-old male known case of CLL, which had previously undergone bilateral cataract surgery in the same session, presented with bilateral decreased vision and vitreous haziness. Vitreous sampling showed aspergillus growth along with negative cytopathology and unremarkable systemic evaluation. Despite 23G deep-vitrectomy and initiation of systemic and intravitreal Voriconazole, a spectacular figure of filamentary branching growth on the IOL/capsular surface appeared in both eyes sequentially, which necessitated bilateral en bloc capsulectomy and IOL removal. Following further recurrence, the patient underwent re-deep vitrectomy, cryotherapy, and medication change to Amphotericin B, which led to a stable ophthalmic state up to this point.
Conclusion: Along with challenging diagnosis in chronic post-op fungal endophthalmitis, anti-fungal resistance, the patient’s immunosuppression, and delayed IOL/capsular removal may lead to a worse prognosis.
Cross-cultural adaptation and validation of the Moroccan Arabic version of the The Schizophrenia Quality of Life short-version questionnaire (SQoL-18)
Authors: Kachouchi Aymen , Sebbani Majda , Karroumi Saadia , Adali Imane , Manoudi Fatiha
Published: May 2023

Background Assessing quality of life (QoL) is an important aspect of the management of chronic diseases such as schizophrenia. However, there is no validated Moroccan specific QoL instrument for schizophrenia patients. This study aimed to adapt and assess psychometric properties of The Schizophrenia Quality of life questionnaire (SQoL-18).Methods We conducted a cross sectional study between May 2022 and October 2022 of 43 patients with schizophrenia attending the psychiatry department at the University hospital Mohamed VI Marrakech, Morocco. The SQoL-18 was translated into Moroccan Arabic language using the forward and backward translation method. The final version was tested for content validity by a panel of experts including psychiatrists and epidemiologists. Internal consistency analysis was performed by measuring Cronbach's alpha, and external validity by testing the correlations with the the Positive and Negative Syndrome Scale (PANSS), the Global Assessment of Functioning and WOOQOL-BREF.Results The Moroccan Arabic version of SQoL-18 was found to have satisfactory content validity. The global Cronbach's alpha was 0,866 and the specific Cronbach’s alpha for the dimensions of SQoL-18 were satisfactory except for one dimension (Self Esteem dimension). Higher QoL levels are globally associated with lower levels of severity of schizophrenia.Conclusion These results demonstrate satisfactory psychometric properties of the Moroccan Arabic version of SQoL-18.
Multilayer spherical shell nanodrug delivery system with spatiotemporal drug release improves tumor microenvironment for synergistic anticancer therapy
Authors: Cai Jiahui , Yang Yibo , Zhang Jia , Bai Zhimin , Zhang Xin , Li Kun , Shi Ming , Liu Zhiwei , Gao Liming , Wang Jidong , Li Jian
Published: May 2023

The inflammatory response is one of the general symptoms that accompany tumorigenesis, and the pro-inflammatory factors cyclooxygenase-2 (COX-2) and COX-2-derived prostaglandin-2 (PGE-2) in the inflammatory environment surrounding tumors possess promoting effects during tumor development，metastasis and angiogenesis. In addition, the hypoxic environment of tumors severely limits the effectiveness of photodynamic therapy (PDT). By using a spatiotemporal controlled Gelatin coated polydopamine (PDA@GN) as the carrier, and loaded with the chemotherapeutic drug doxorubicin (DOX), the photosensitizer indocyanine green (ICG), the PDT enhancer MnO2 and the anti-inflammatory drug celecoxib (CEL) individually, we developed an effective and universal extracellular-intracellular "on-demand" release nanomedicine DOX@PDA-ICG@MnO2@GN-CEL for the combined fight against malignant tumors. Our results showed that GN could release CEL extracellularly by MMP-2 response at tumor microenvironment (TME) and inhibit the COX-2/PGE-2 pathway, which could reduce chemotherapy resistance, attenuate the concurrent inflammation and the damage to surrounding normal cells of photothermal therapy (PTT) induced by PDA and ICG. After entering the tumor cells, PDA released DOX, ICG and MnO2 intracellularly through acid response. MnO2 promoted the degradation of endogenous H2O2 to generate oxygen under acidic conditions to alleviate the tumor hypoxic environment, which enhanced PDT triggered by ICG, PDA and ICG exhibited PTT synergistically, and DOX exerted chemotherapy with little chemotherapy resistance. The dual response drug release switch enabled the chemotherapeutic, photothermal, photodynamic and anti-inflammatory drugs precisely acted on different sites of tumor tissues and realized a promising multimodal combination therapy.
Extracellular Matrix Organization Genes Predict the Prognosis and Immune Microenvironment in Stomach Adenocarcinoma
Authors: Liu Qun , Wang Yan , Wang Kuo , Li Zhaoshui , Dong Quanjiang
Published: May 2023

Background
Extracellular matrix (ECM) dysregulation is crucial for malignant progression of human cancer. However, its effect on immune microenvironment of stomach adenocarcinoma (STAD) is unclarified.
Method
The Cancer Genome Atlas (TACG) database was utilized to retrieve STAD gene expression profiles and clinical information. Genes significantly associated with prognosis (P < 0.05) were assessed by univariate Cox regression. The Gene Ontology (GO) enrichment and protein-protein interaction (PPI) network were performed to identify the critical bioprocesses. Multivariate Cox regression and the least absolute shrinkage and selection operator (LASSO) were utilized to identify independent prognostic signature. Differentiating between clusters according to ECM organization gene expression (ECMOGs) was achieved by unsupervised clustering analysis. The biological characteristics in the ECMOGs clusters were determined. The tumor microenvironment (TME) features, including immunization checkpoint block (ICB) response, immune checkpoint genes, and tumor-infiltrating lymphocytes, were predicted between the distinct clusters.
Results
A total of 948 genes were identified as STAD prognostic genes. ECM organization was found to be the most significant bioprocesses these prognostic genes enriched in. Twelve ECMOGs were considered to be linked to the development of STAD. Three ECMOGs (ADAMTS1, LOX, NFKB2) were determined as independent predictor signatures for risk scoring. Based on twelve ECMOGs expression, the 348 patients were divided into cluster 1 and 2. Patients in cluster 1 had the higher levels of the detected ECMOGs and the risk score, as well as the poor prognosis. Cluster 1 was distinguished by its higher ICB response as well as the infiltrated M2 macrophage.
Conclusion
This study demonstrated that ECMOGs were associated with a bad prognosis partly by affecting the immune microenvironment, which could be the potential biomarker for the diagnosis and prognosis, and therapeutic target in STAD.
Epicatechin mediated modulation of the Nrf2/HO-1 pathway alleviates senile cerebral ischemic/reperfusion injury
Authors: Jiang Changyue , Xie lu , Hu wangxiang , zhuge xiangzhen , chen menghua , Li Deli
Published: May 2023

The aging of the global population has resulted in a significant increase in the incidence of stroke, disability, and mortality. Findings from numerous studies suggest that ROS generated during ischemic reperfusion are crucial in subsequent tissue damage. However, the role of nuclear factor-erythroid 2-related factor 2 (Nrf2), which regulates endogenous antioxidative functions, in pathological models of aging is not well understood. Our previous study showed that epicatechin (EC) upregulated brain Nrf2 expression in 2-month-old rats and reduced oxidative stress in cerebral ischemia-reperfusion injury (CIRI). In the present study, EC was administered to a 12-month-old rat model of CIRI (induced by middle cerebral artery occlusion and reperfusion) and a senescent SH-SY5Y cell model subjected to oxygen glucose deprivation/reoxygenation. EC treatment improved cerebral morphology and function; increased p-Nrf2 expression and unclear transportation and HO-1, SOD, and GSH expression; and reduced infarct volume and apoptosis in senescent rats. Moreover, EC enhanced cellular activity and the expression of p-Nrf2, HO-1, and NQO-1 while decreasing the ROS and MDA levels and mitigating apoptosis in senescent SH-SY5Y cells. These effects were attenuated upon si-Nrf2 introduction. The findings of this study offer novel insights into stroke prevention and therapy as well as drug development for the elderly population.
The rational modulation of autophagy sensitizes colorectal cancer cells to 5-fluouracil and Oxaliplatin
Authors: Baldasso-Zanon Andrea , Silva Andrew Oliveira , Franco Nayara , Picon Rafael , Lenz Guido , Lopez Patrícia Luciana da Costa , Filippi-Chiela Eduardo
Published: May 2023

Colorectal cancer (CRC) is the third most common and deadliest cancers globally. The primary chemotherapy used for treating CRC is a co-treatment of 5-fluoruracil (5FU) and Oxaliplatin (OXA). In this study, we investigated the cellular mechanisms that contribute to the response and resistance of CRC cells to these drugs using an experimental design mimicking the clinical schedule. To this, we treated and analyzed CRC human cell lines HCT116 and HT29 with the drugs for 48h, followed by analysis for two additional weeks. We found that although the drugs did not show additive toxicity at 48 hours, they had a strong additive effect in the weeks post-treatment, reducing both the regrowth of cell population and the proliferative capacity of single cells. Co-treatment induced apoptosis and senescence, peaking at 3 days and 7 days after treatment, respectively. However, despite this, cells from all conditions resumed population proliferation and acquired a viable phenotype. We then search for cellular mechanisms involved in the tolerance and recurrence of CRC cells. In the weeks post-treatment, the co-treatment showed the greatest toxicity and, in contrast to single treatments, blocked the enrichment of CD133-positive cells. Furthermore, our findings indicated that cells that resisted 5FU and/or OXA triggered high levels of autophagy. Autophagy levels reached a peak 5 to 7 days after the treatment. Pharmacologic suppression of autophagy during its activation, but not together with the chemotherapeutics, strongly reduced cell regrowth and clonogenicity. Overall, our preclinical model provides new insights into the cellular mechanisms that underlie the response and resistance of CRC cells to 5FU and OXA, suggesting optimized, time-specific autophagy inhibition as a new avenue for improving the efficacy of current treatments.