bluuebunny/crossref_metadata_2025 huggingface dataset:
REVITALISASI LOKANANTA SURAKARTA
Authors: Nugrahani Adysty , Samsudi Samsudi , Purnomo Agus Heru
Published: July 2017

Abstract:Lokananta Surakarta be one proof of the historical progress of Indonesian music industry. However, because the decline since the late 80s caused by many things, Lokananta gradually dropped prestige resulting in the lonely recording and production activities that culminate in the building neglected and not maintained. In 2014, Lokananta including the 100 buildings and the heritage area of Surakarta, this became the basis for the existence Lokananta preserved and developed. The problem faced is how to revitalize Lokananta that can accommodate all the activities that take place in it by promoting the principle of preservation and revitalization of existing noticed that existed at this time. The purpose of the revitalization Lokananta is generating Lokananta that can accommodate recording activities, recreation, and education. The application of revitalization is done with the protection and maintenance of the main building as well as by adding facilities supporting the activities of musical performances both indoors and outdoors, as well as the infrastructure of leisure activities and education in the form of exhibition venues associated with the development of music and collections owned by Lokananta with regard to rules of preservation and revitalization, and with regard to existing conditions. Revitalization Lokananta Surakarta produce Lokananta able to accommodate the activities of recording, performances, recreation and education and support facilities which can provide added value to Lokananta.

 

Keywords: Lokananta Surakarta, Revitalization, Conservation, Preservation
ARSITEKTUR BERKELANJUTAN PADA SEKOLAH TINGGI ASTRONOMI DAN KEDIRGANTARAAN DI YOGYAKARTA
Authors: Arini Tiara , Wahyuwibowo Agung Kumoro , Iswati Tri Yuni
Published: July 2017

Abstract: Astronomy is a natural science that studies celestial objects and phenomena that include observation and explanation, occurs outside Earth and its atmosphere. Location of Indonesia which is at the equator enables the constellations in north sky and south sky can be observed very well. In Asia Pacific, astronomy in Indonesia is also growing and interested by many researchers from abroad. Astronomy also has relationship with aerospace engineering. Aerospace engineering studies about aircraft design. PT Dirgantara Indonesia is also the first and only one aircraft company in Southeast Asia. However, there are obstacles in these potentials, as in Indonesia, astronomy formal education is only at Institut Teknologi Bandung (ITB). Besides, facilities and infrastructures to study astronomy are still concentrated in Java. Yogyakarta is known as “Kota Pelajar” where the dynamics of education and tourism are strong enough to make it possible to deliver a High School of Astronomy and Aerospace, precisely in Gunungkidul Regency. Gunungkidul have ecological conditions that are still green and far away from the word "metropolitan" so as can be a place to facilitate astronomical observation. From this location, Sustainable Architecture becomes an approach that combines the aspects of efficiency, conservation, and durability that can be applied to the building and the environment. The efficiency is applied in energy use, particularly in the use of sun light and wind direction, as well as the efficiency of land use, so that not all of the site is covered by buildings that can provide green open space. On the conservation aspect is closely linked to sustainable development, especially in the use of natural resources. Conservation will keep the natural resources remain on a sustainable point. Durability is the resistance of a building and environment. In this case, how to make the building can last a long time because of the threat around the environment is minimized. It begins from site planning, the use of land that is not harmful to the building and surrounding communities.

 

Keywords: aerospace, astronomy, education, Gunungkidul, high school, sustainable architecture.
Estimation of heart cavities remodeling in patients with acute pulmonary thromboembolism by echocardiography
Authors: Matveeva N. V. , Nartsissova G. P. , Karpenko A. A. , Chernyavskiy M. A.
Published: July 2017

We analyzed echocardiography data of 69 patients with acute PTE before operation, during short-term and long-term postoperative periods. Local kinesis abnormalities of the right ventricle anterior wall known as a "McConnell sign" were found in 24% of cases (11 patients) with moderate PH and in 62% of cases (13 patients) with significant PH. The PH level tended to significantly decrease in the postoperative period. The dilatation of the right heart departments and pulmonary artery was observed to decrease after the procedure of catheter fragmentation and thrombolysis. The effect of operation remains constant in the long-term period.
Surgical treatment of patients with critical ischemia of lower limbs originating from aortoiliac lesions and concomitant coronary artery disease
Authors: Vachev A. N. , Sukhorukov V. V. , Surkova Ye. A. , Gureev A. D. , Krugomov A. V. , Chernovalov D. A. , Mikhaylov M. S.
Published: July 2017

The study focuses on the outcomes of surgical treatment of 236 patients with critical ischemia of lower limbs originating from aortoiliac lesions and concomitant coronary artery disease. All patients first underwent vascular surgery, with 158 of them having aortobifemoral bypass surgery and 78 - hybrid vascular procedures on the aortoiliac segment: open surgical revascularization of femoral arteries and angioplasty and stenting of iliac arteries. Critical limb ischemia was successfully treated in all patients. One patient died after aortobifemoral bypass surgery; no fatal outcomes were registered after hybrid procedures.
Does the type of ablation device influence on the results of the treatment of atrial fibrillation in open heart surgery?
Authors: Bogachev-prokofev A. V. , Zheleznev S. I. , Pivkin A. N. , Lavinyukov S. O. , Karaskov A. M. , Ivanov I. V.
Published: July 2017

We analysed results of different types of monopolar and bipolar radiofrequency (RF) ablation in the surgical correction of valvular heart disease. From 2007 to 2011, RF ablation procedure performed 283 patients with atrial fibrillation and heart valve disease. Depending on the type of ablation electrode, all patients were divided into three groups: 64 (22.6%) cases monopolar ablation (MA), irrigated bipolar electrode (IBE) was used in 83 (29.3%) cases and dry bipolar ablation (DBA) formed 136 (48.1%). Time of ablation schemes using a monopolar electrode was significantly more, what increased time of aortic cross-clamping and cardiopulmonary bypass. No significant differences in the time parameters for groups of IBE and DBA has been received. Mortality in the hospital stay was not significantly different between the groups, reaching for the MA, IBE and DBA groups 1.5, 1.2 and 2.2% (p = 0.957; p = 0.784; p = 0.139). In neither case death was not directly related to the ablation procedure and type of electrode. Freedom from AF and AT in groups using bipolar ablative devices was significantly higher at all stages of the assessment results, amounting to MA, IBE and DBA groups, 68.1%, 84.0% and 85,7% respectively (log-rank test, p = 0.012 to DBA group and p = 0.021 for Group IBE). No significant differences between the use of irrigated electrodes and execution of the dry ablation were found (log-rank test, p = 0.249).
Change of descending aortic false lumen after repair of type I dissection by De Bakey
Authors: Chernyavskiy A. M. , Alsov S. A. , Lyashenko M. M. , Sirota D. A. , Khvan D. S.
Published: July 2017

Group of authors analyzes the state of thoracoabdominal aorta after reconstruction of ascending and arch of aorta. Currently, there is no single point of view on the amount of interference in the ascending part and the aortic arch in preventing complications of thoracoabdominal aorta. In a group of 46 patients the authors by means of issuing a series of multislice computed tomography, performed at different times after surgery and examine the status thoracoabdominal aorta at different levels. Based on the results of the study revealed that, under the first phase of the surgery department at the ascending aorta and arch over her bundle for DeBakey type I, there is no need to take in a false lumen in the descending thoracic aorta, as it not only does not reduce or slow dilation thoracoabdominal aorta in the long-term, but it is a more rapid increase in comparison with patients with a false lumen was. Saving or suturing the false lumen does not affect the incidence of thrombosis in late postoperative period, and therefore, closure of a false channel in the first phase of intervention is inappropriate.
Prognostic value of total lymphocyte count in cardiac surgery
Authors: Lomivorotov V. V. , Yefremov S. M. , Boboshko V. A. , Shmyrev V. A.
Published: July 2017

The aim of this study retrospective cohort was to investigate the prognostic value of preoperative total lymphocyte count in peripheral blood as a predictor of postoperative complications and mortality in cardiac surgery. All adults undergoing cardiopulmonary bypass in 2009. The cohort size was 1 368 patients. Patient characteristics, hospital mortality, postoperative complications, ventilation period, intensive care unit and hospital stay were analysed. Preoperative total lymphocyte count <1 611 cells/L was assotiated with significantly higher mortality by univariate (p<0,0001) and multivariate (p<0,022) analisys. Low preoperative total lymphocyte count was associated with more frequent inotropic support (p<0,001); postoperative heart arrhythmia (p<0,001); hemodialysis-dependent acute renal failure (p<0,001); and a prolonged ventilation period (p=0,001), intensive care unit stay (p<0,001), and hospital stay (p=0,007). Low preoperative total lymphocyte count in peripheral blood is a useful prognostic criterion for evaluation of a complicated postoperative period in cardiosurgical patients.
Efficacy of pulmonary artery banding in patients with uneventricular defects
Authors: Sinelnikov Yu. S. , Gorbatykh Yu. N. , Ivantsov S. M. , Matyushov V. N. , Soynov I. A. , Kshanovskaya M. S. , Chashchin O. V. , Zubritskiy A. V.
Published: July 2017

Long-term results where evaluated for different methods of pulmonary artery banding (PAB) in 25 patients with univentricular congenital heart defects with used three methods. Hospital mortality was 8%. Second stage palliation was performed in 61% of patients. More tight PA banding in patients with univentriclar gave opportunity to perform 2nd stage of operation in 100% of patients, decrease complications and mortality rate, modify pulmonary circulation effectively.
Effects of biocompatible extracorporeal bypass circuit coating Bioline in cardiac surgery patients
Authors: Ponomarenko I. V. , Shipulin V. M. , Ogurkova O. N. , Suslova T. Ye.
Published: July 2017

Biocompatibility of heparin-based coating for extracorporeal circuits, the Bioline, was evaluated in cardiac surgery setting. Thirty six CABG pts, aged from 30 to 69 yrs, were randomly perfused with a circuit containing Bioline-coated Quadrox oxygenator (Bioline, n=18) or with a similar non-coated circuit (control, n=18). Leukocyte and platelet counts, levels of tumor necrosis factor, interleukin-6 and fibrinogen were assessed in arterial blood before, during and after cardiopulmonary bypass (CPB). Oxygenation and ventilation indices before and after surgery, post-operative chest tube drainage and transfusion volume as well as the duration of assisted ventilation were also measured. A platelet count and fibrinogen dropped less in the Bioline group significantly compared with that in control at the end of CPB (p<0,05) and after protamine administration (p<0,05). A leukocyte count and an interleukin-6 level increased more in controls after CPB (p<0,05) as well as oxygenation and ventilation indices, bleeding volume and intubation time (all p<0,05). Our results suggest surface heparinization with Bioline coating limited to the oxygenator ameliorates the inflammatory response, preserves fibrinogen and platelets, reduces blood loss postoperatively and improves lung function during CPB.
Interrelation of the heart rate turbulence with the clinical, functional and morphometric parameters among the patients with arterial hypertension
Authors: Pospelova T. I. , Nikolaev Yu. A. , Kishkurno S. G.
Published: July 2017

There have been explored 225 males in the age from 50 to 74 with an arterial hypertension (AH). For all the patients there have been carried out the recording of electrocardiogram (ECG) in the state of rest, ECG monitoring with a Holter identify indicators heart rate turbulence (HRT) and dynamic load testing (test with a 6 minute walk test, treadmill and bicycle ergometry). There was founded, that among the patients with an arterial hypertension after 50 years the number of ventricular premature beats grows up. With increasing of the age the normal values decrease and the pathological values increase heart rate turbulence (HRT), average slope of turbulence slope (TS). Dynamic load testing of patients after 70 years shows an increase in common, stress-induced ventricular arrhythmia, which is associated with ischemic-segment ST. Among the patients with arterial hypertension and frequent load-induced ventricular premature beats, in comparison with a rare, indicators of the HRT have a higher value. HRT among the patients with an arterial hypertension has a relationship with clinical and functional morfomerical indicators. The values turbulence onset (TO) of these were linked to the index left ventricular mass, pulse pressure, the number of ventricular premature beats, the average hemodynamic blood pressure, age and the values of circadian index (CI). The indicators TS are associated with index left ventricular mass, pulse pressure, the number of ventricular premature beats, with an average hemodynamic blood pressure, c values of the age and circadian index (CI).
The first experience with the implantation of the prosthesis xenopericardial frame variable stiffness "Tiara" in the aortic position
Authors: Astapov D. A. , Demidov D. P. , Semenova Ye. I. , Zheleznev S. I. , Zorina I. G. , Syrtseva Ya. V.
Published: July 2017

Represents the results of a clinical trial implantation xenopericardial prosthesis mounted on a frame of variable stiffness "Tiara" in the aortic position. Prosthesis implanted in a single-row suture cubcoronary supraannulary position. Implantation performed two patients 71 and 75 years with a good clinical outcome. According to the control echocardiography peak gradients at rest were 9-15 mm Hg. According to the results of a clinical trial prosthesis can be recommended for implementation in everyday clinical practice.
A clinical case of surgical treatment of echinococcosis of the heart
Authors: Aminov V. V. , Tereshchenko D. R. , Ignatov Ye. V. , Davydov S. N.
Published: July 2017

This paper presents a single case report of surgical treatment of echinococcosis of the heart in a 22-year-old woman. Papers of others surgical clinics are given for comparison.
Effects of caspase 8 gene polymorphism on the risks for development/course of chronic heart failure
Authors: Berezikova Ye. N. , Pustovetova M. G. , Shilov S. N. , Yefremov A. V. , Teplyakov A. T. , Safronov I. D. , Samsonova Ye. N.
Published: July 2017

The aim of the study was to identify genetic determinants of increased risks for heart failure severity. Clinical and genetic aspects of the effects of gene polymorphism caspase 8 (polymorphic loci -652(6N)I/D and D302H) on the risks for development and severity of chronic heart failure (CHF) in patients with coronary artery disease were investigated. 277 patients with CHF were studied (182 males and 95 females aged 45 to 65 years (mean age 59.27.7 years). Genotypes were identified by using RFLP analysis of PCR products. The control group included 136 people (mean age 53.64.8 years) who had no symptoms of cardiovascular disorders. The presence of del allele and genotype del/del polymorphic locus -652(6N)I/D gene caspase 8 was associated with an increased risk for heart failure, while the allele ins and genotype ins/ins were found to serve as protective factors. Allele ins and genotype ins/ins polymorphic locus -652(6N)I/D gene caspase 8 proved to be associated with protective effects on the course of CHF in patients with coronary artery disease, while allele del and genotype del/del could be considered as predictors of an unfavorable course of the disease. The analysis revealed no significant differences in the frequency distribution of genotypes and alleles of polymorphic loci D302H gene caspase 8 in patients with chronic heart failure and in the control group, as well as in the dependence on the functional class of heart failure. The definition of polymorphism -652(6N)I/D gene caspase 8 can be recommended for early prediction of risks and severity of heart failure.
The long-term efficacy of an ablation procedure in patients with low LV ejection fraction and ventricular tachyarrhythmias originated from right ventricular outflow tract
Authors: Sakovich V. A. , Strelnikov A. G. , Shabanov V. V. , Kamiev R. T. , Romanov A. B. , Pokushalov Ye. A. , Ivanitskiy E. A. , Kropotkin Ye. B.
Published: July 2017

The aim of this prospective observational study was to assess efficacy and safety of the ablation procedure in patients with low LV ejection fraction (LVEF) and ventricular tachyarrhythmias originated from right ventricular outflow tract (RVOT) during long-term follow up. Fifty four consecutive patients with symptomatic premature ventricular complexes (PVC) or ventricular tachycardias (VT) with left bundle branch block (LBBB) pattern, inferior axis morphology and transition zone predominantly in V3-V4 were included in this study. The patients were followed up during 36 months after ablation procedure. The mean follow up period was 42.26 months. The long-term efficacy after one ablation procedure was 94.4% (51 patients) and after redo procedures - 98.1 % (53 patients). The LVEF increased from 422 at baseline to 565% after 36 months of follow up (p = 0.001). Radiofrequency catheter ablation in patients with low LVEF and ventricular tachyarrhythmias originated from RVOT is a safe and highly effective treatment during long-term follow up.
Prognostic role of metabolic risk factors (hyperhomocysteinemia) in the development of chronic heart failure
Authors: Berezikova Ye. N. , Pustovetova M. G. , Shilov S. N. , Yefremov A. V. , Teplyakov A. T. , Safronov I. D. , Samsonova Ye. N.
Published: July 2017

The aim of the study was to assess the relationship of homocysteine levels in the blood serum with the severity and nature of chronic heart failure (CHF) in patients with coronary heart disease. 94 patients with CHF were examined. The control group included 32 patients without cardiovascular disorders. At baseline and after 12 months of observation the homocysteine levels in the blood serum were determined by enzyme-linked immunosorbent assay. Correlative relationship of hyperhomocysteinemia with ischemic myocardial remodeling and with reduced inotropic function in CHF patients was observed. The homocysteine level in the blood serum of CHF patients significantly exceeded that of the control group and moderately increased with the progression of the disease severity of functional class. In the group with an unfavorable course of CHF the baseline homocysteine level proved to have the greatest value as compared to that in the group with a favorable course. In patients with a favorable course of CHF the homocysteinemia level tended to decrease towards the end of prospective study, whereas in patients with an unfavorable course, on the contrary, hyperhomocysteinemia persisted (p<0.01). In case the hyperhomocysteinemia baseline exceeds 18.5 mkmol/L (ROC-AreaSE = 0.860.04, sensitivity 71 %, specificity 90%), the severity and characteristics of the ischemic CHF could be most likely predicted. Thus, hyperhomocysteinemia is related with the severity and nature of CHF. Determining the level of homocysteine in the blood serum can be recommended for early prediction of the severity and nature of CHF.
Functional characteristics of peripheral blood mononuclear cells after administration of granulocyte colony-stimulating factor in patients with chronic heart failure
Authors: Poveshchenko O. V. , Kim I. I. , Bondarenko N. A. , Lykov A. P. , Poveshchenko A. F. , Pokushalov Ye. A. , Romanov A. B. , Karaskov A. M. , Konenkov V. I.
Published: July 2017

It is shown that the introduction of granulocyte colony stimulating factor (G-CSF) in patients with chronic heart failure increases the functional activity of peripheral blood mononuclear cells (MNC). Enriching peripheral blood MNCs with progenitor cells (PC) by mobilization of bone marrow leads to an increase of their proliferative capacity both under spontaneous culture conditions and when stimulated with ConA mitogen and cytokines G-CSF. Proliferative activity of MNCs is found to increase, as the number of CD34+ PC starts growing. It is also noted that MNCs produce a wide range of cytokines with regulatory action after mobilization in a 48-hour culture in vitro. The findings suggest the feasibility of using MNCs after G-CSF mobilization for stimulation of reparative processes in the myocardium.
Alternative conduits for coronary bypass surgery
Authors: Sukhanov S. G. , Orekhova Ye. N. , Kadyraliev B. K.
Published: July 2017

During the last decade many countries have witnessed a dramatic increase in the number of patients undergoing coronary artery bypass grafting. As a consequence, the number of patients with insufficient or inadequate autologous vessels suitable for use as coronary artery grafts is also increasing. These patients may include those who have had previous heart operations, as well as those with bilateral varicose veins and phlebectomy. Given the shortage of autologous grafts, prosthetic and biological conduits are available for use in CABG. However, a small-diameter vascular prosthesis with acceptable long-term patency still remains the cherished wish for cardiovascular surgeons.
Comparison of results of staged and hybrid approaches in surgical treatment of patients with coronary heart disease and cerebrovascular disease
Authors: Bazylev V. V. , Rosseykin Ye. V. , Voevodin A. B.
Published: July 2017

We compared the immediate outcomes of hybrid procedure and step-by-step internal carotid artery (CA) stenting and coronary artery bypass grafting (CABG) in high-risk surgical patients with combined lesions of coronary and carotid vasculature. The indications for hybrid surgery were identified. 50 patients with combined lesions of the coronary bed and the carotid vasculature were divided into two groups. The 1st group had 30 patients (60%), who first underwent CA stenting followed by CABG. The 2nd group included 20 patients (40%), who underwent hybrid procedures (simultaneous CA stenting and CABG). Patients with atherosclerosis of aortoiliac and femoropopliteal segments (p <0.0001) were by far more frequent in the hybrid procedures group. The 1st group was found to have no fatal outcomes. 3 patients (10%) experienced cerebral stroke. The hybrid procedures group had no deaths and cerebral stroke patients. 2 patients developed a myocardial infarction. None of the above indices was found to have statistically significant differences between the groups (р >0.05). On average, the patients of the 1st group were in the Intensive Care Unit (ICU) for 2.91.9 days; the patients of the 2nd group stayed in the ICU for 3.96.4 days (р = 0.42). The average postoperative hospital stay for the 1 st group patients amounted to 10.84.5 days, while that for the 2nd group patients was equal to 10.85.8 days (р = 1). The groups were found to have no statistically relevant differences of complication risks, the length of ICU stay, and the total number of days spent in hospital. If patients with combined lesions of the coronary artery and the carotid artery also suffer from critical lower-extremity stenosis, a hybrid procedure allows surgeons to perform CA stenting.
Results of surgical treatment of patients with glioblastomas using a combined 5-ala fluorescent-guided resection
Authors: Gaytan A. S. , Krivoshapkin A. L. , Karaskov A. M. , Kanygin V. V. , Valentik A. V.
Published: July 2017

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. It was previously shown that 5-ala fluorescence-guided resection (FGR) of malignant gliomas, as compared to white-light microscopy resection, demonstrates a significantly higher frequency of complete removal of the contrast-enhancing tumor and significantly prolongs overall survival. A combination of 5-ala microscopy and endoscopy may provide some benefits for GBM surgery. The purpose of this study was to evaluate the immediate results of combined 5-ala FGR in patients with GBMs. All in all, 80 patients with GBMs were operated at two independent neurosurgical centers. Patients of the first group (n = 40) were operated by using the combination of 5-ala microscopy and endoscopy. The second (control) group patients (n = 40) underwent conventional white light microsurgery. MRI with contrast agent was done preoperatively and within 72 hours after surgery accompanied by volumetric analysis of the tumor. The patients' functional class was determined a day before surgery and 10 days after it. A comparative analysis of GBM resection by using MRI neuronavigation and combined fluorescence-guided navigation shows that the latter considerably increases the total percentage of GBM resection (27.5% and 65% respectively) and improves the functional class in the immediate postoperative period.
Prevention of gastrointestinal injury by using glutamine in cardiac surgery
Authors: Yefremov S. M. , Shmyrev V. A. , Deryagin M. N. , Kornilov I. A. , Shilova A. N. , Karaskov A. M. , Lomivorotov V. V. , Ponomarev D. N.
Published: July 2017

A pilot double-blind, placebo-controlled, randomized study The aim of this study was to evaluate the efficiency of perioperative administration of glutamine to preserve intestinal integrity in patients undergoing cardiac surgery. 24 patients scheduled for elective coronary artery bypass surgery under cardiopulmonary bypass were included in this prospective, randomized, double-blind placebo controlled pilot study. 12 patients were randomized to receive glutamine (20% solution of N(2)-L-alanyl-L-glutamine) 0.4 g/kg a day, while the remaining 12 patients received an equivalent placebo dose (0.9% solution of NaCl). Infusion of glutamine/placebo was started after the induction of anesthesia and was continued for 24 hours. The primary end-point was dynamics of plasma concentration of a specific marker of intestinal damage, intestinal fatty acid binding protein (I-FABP). The secondary end-points were liver fatty acid binding protein (L-FABP), alpha glutathione s-transferase (aGST), heat shock protein 70 (HSP 70). There were no between-group differences of all the studied biochemical parameters at any stage of the study. Plasma I-FABP levels (median [25-75 percentile]) were markedly elevated during CPB and remained the same postoperatively: 962 (577-2 067) and 883 (444-1 625) г/ml 5 min after un-clamping of aorta, 2203 (888-3 429) and 1 560 (506-2 657) г/ml 2 hours post-bypass, 897 (555-1 424) and 794 (505-951) г/ml 6 hours post-bypass in the GLN and control groups respectively. Perioperative administration of glutamine in dose of 0.4 g/kg a day does not appear to preserve intestinal integrity in low risk cardiac surgery patients.
Cardioand neuroprotection with volatile anesthetics in cardiac surgery
Authors: Borisov K. Yu. , Levikov D. I. , Grebenchikov O. A. , Likhvantsev V. V. , Shaybakova V. L. , Cherpakov R. A.
Published: July 2017

The researcher's opinions about myocardial and brain anesthetic preconditioning efficiency are yet contradictive. In addition, the anesthetic neuroprotection phenomenon is poorly investigated. In this study the authors attempted to evaluate the efficiency of myocardial and central nervous system (CNS) protection by using a modified method of volatile induction and maintenance of anesthesia (VIMA) based on pulse-like sevoflurane dosing that excludes propofol usage. Ninety CABG patients aged 45-75 years were included in the study group (VIMA) and underwent volatile induction with sevoflurane and anesthetic preconditioning (2 MAC) for 10 min before aortic cross-clamping, with ataralgesia used during CPB. The control group patients (TIVA) received propofol and fentanyl, no inhalation anesthetics were applied. Preoperative concentrations of NTpro-BNP were comparable. There was no significant rise of NTpro-BNP concentration in the VIMA group during the postoperative period. In the TIVA group NTpro-BNP concentrations were 3.8 and 4.8 times as much as the baseline values at 24 and 48 postoperative hours respectively (р<0.05). 17 patients in the VIMA group needed dopamine infusion during 24 postoperative hours, this number was 1.7 times less than that in the TIVA group (23 patients) (р<0.05). VIMA patients had 2-fold lower troponin T concentration in 24 hours after surgery (р<0.01). Significant differences in protein S100B concentrations were observed only during the postoperative period. No significant differences in cognitive functions of the patients from both groups were identified before surgery. On postoperative day 2 MMSE scale count was significantly lower in TIVA patients (20.843.73) in comparison with VI-MA patients (23.364.34) (р<0.05). Thus, the modified VIMA technique with sevoflurane has a greater neuroprotective potential during CABG with CPB and provides better preservation of myocardium structural integrity and cardiac performance than fentanyl/4propofol-based TIVA would do.
Regional oxymetry provides safety of the patient during cardiaс surgery
Authors: Akselrod B. A.
Published: July 2017

The state-of-the-art regional oxygenation evaluation during perioperative period in cardiac surgery is presented. The importance of a regional oxymetry method based on NIRS and used to assess hemodynamic efficiency during anesthesia is demonstrated. This method helps to increase the safety of patients during cardiac and vascular surgery due to a decrease of tissue ischemic damage. Regional oxymetry enables to evaluate oxygen transport adequacy, identify the risk groups and modify the therapy used. Disadvantages and limitations of the regional oxymetry method are also discussed.
Dexmedetomidine for sedation of cardiosurgical patients
Authors: Kozlov I. A. , Krichevskiy L. A.
Published: July 2017

The problem of sedation in cardiosurgical intensive care units has obvious scientific and practical relevance. Many current studies deal with the implementation of novel medications for sedation, some features of their pharmacodynamic effects in different clinical settings, with advantages and disadvantages of their use in cardiosurgical patients. Recent years have seen an increase in the number of publications on the 2-adrenoceptor agonist dexmedetomidine used for sedation after open-heart surgery. The paper reviews current publications on 2-adrenoceptor agonists used in anesthesiology, considers their physiology and the mechanism of sedative action of dexmedetomidine, its pharmacokinetics and pharmacodynamics. The experience in using dexmedetomidine sedation in clinical practice is discussed in detail, by analyzing the data of current multicenter randomized trials in which this drug was compared with other sedative medications (propofol, midazolam, lorazepam). Some aspects of clinical pharmacology of dexmedetomidine, such as its effect on the sympathoadrenal system, hemodynamics, and respiratory system are analyzed. The clinical value of different receptor-dependent effects of the drug and the specific features of its application in different situations are also discussed. The authors share their own experience on delirium treatment and non-invasive ventilation in patients who receive dexmedetomidine sedation after heart transplantation and cardiac surgery.
Ten years of transesophageal echocardiography in domestic cardiac anesthesiology
Authors: Kozlov I. A. , Krichevskiy L. A. , Dzybinskaya Ye. V.
Published: July 2017

This article summarizes the experience of a ten-year period of implementation and use of intraoperative transesophageal echocardiography in Russia's cardiac anesthesiology. The possibilities of this method as part of hemodynamic monitoring for various types of cardiac surgery are shown. The advantages of prognostic significance of echocardiographic parameters are demonstrated and proven in comparison with the standard parameters. Nevertheless, it is noted that ultrasound monitoring has not gained proper acceptance in domestic practice that requires attention of clinicians and medical administrators.
Occlusion of left atrial appendage in patients with atrial fibrillation
Authors: Ganeeva O. N.
Published: July 2017

The article reviews a new method of prophylaxis of thromboembolitic complications, specifically occlusion of left atrial appendage, in patients with atrial fibrillation. Indications and contraindications for the procedure, as well as a step-by-step process of the intervention itself are described. Special emphasis is placed on the up-to-date evidence and the review of clinical trials.
Modulation of sympathetic nervous system by means of renal denervation for treatment of atrial fibrillation
Authors: Romanov A. B. , Pokushalov Ye. A. , Zamanov D. A. , Dmitriev A. Yu. , Shilnikov N. V. , Ivanitskaya E. E. , Pustovoytov A. V.
Published: July 2017

The autonomous nervous system plays a key role in modulation of cardiac electrophysiology. Despite a great body of data on the presence of anatomic and functional relations between the nervous system and the heart, there remain a number of questions unanswered. Denervation of renal arteries or renal denervation (RDN) has become a crucial interventional technique when treating resistant arterial hypertension (AHT). Since the latter is the most prevailing cardiovascular disease complicating the course of heart rhythm disorders, atrial fibrillations in particular, it would be a good idea to study a potential value of RDN as antiarrhythmic therapy.
Catheter versus surgical ablation of atrial fibrillation after failed initial pulmonary vein isolation
Authors: Yelesin D. A. , Romanov A. B. , Bogachev-prokofev A. V. , Losik D. V. , Bayramova S. A. , Shabanov V. V. , Strelnikov A. G. , Pokushalov Ye. A.
Published: July 2017

The aim of this prospective randomized study was to compare the efficacy and safety of catheter ablation (CA) versus surgical ablation (SA) in patients with paroxysmal (P) and persistent (Pers) AF after failed initial pulmonary vein isolation. The patients with symptomatic AF (59 PAF and 41% Pers AF) after a previously failed primary RF ablation procedure were eligible for this study. The patients were randomized to CA (n = 32) or video-assisted SA (n = 32) redo ablation. The primary end-point of the study was the absence of any atrial tachyarrhythmias after a second ablation procedure during 12-month follow-up. At the end of observation, 26 (81 %) of the 32 SA group patients were AF/AT-free. In contrast, in the CA group, only 15 (47%) of 32 patients were AF/AT-free (p=0.004, log-rank test). Both groups received no antiarrhythmic drugs. In patients with PAF, 17 (85%) patients of 20 in the SA group and 10 (56%) patients of 18 in the CA group were AF-free (p=0.04, log-rank test). In patients with Pers AF, 9 (75%) patients of 12 in the SA group and 5 (36%) patients of 14 in the CA group were AF-free (p=0.04, log-rank test). The total number of postoperative complications was higher in the SA group as compared with that in the CA group (7 and 1 complications respectively, р = 0.02). In patients with PAF and PersAF after failed initial catheter ablation, video-assisted thoracoscopic surgical ablation is superior to endocardial catheter ablation for maintenance of the sinus rhythm. However, SA results in a higher rate of complications.
Epicardial ablation of premature ventricular beat from right ventricular outflow tract following ineffective endocardial ablation
Authors: Sakovich V. A. , Yakubov A. A. , Shabanov V. V. , Romanov A. B. , Pokushalov Ye. A. , Ivanitskiy E. A. , Drobot D. B.
Published: July 2017

A case of epicardial ablation of premature ventricular beat (PVB) originating in RVOT outflow tract in an 18-year old patient with frequent symptomatic drug-induced PVB after ineffective endocardial ablation is described. Multiple RF applications by using an irrigated catheter on the side of RVOT turned out ineffective. During epicardial mapping the source of PVB also was in the RVOT area, but with a greater relative and absolute lead. In the course of epicardial ablation, PVB tended to 'heat up', pass into ventricular tachycardia followed by the tatter's arrest and then disappear. At 12-month follow-up the patient showed no ventricular arrhythmias without any antiarrhythmic drugs.
Idiopathic ventricular heart rhythm disturbances originating in the right ventricular apex
Authors: Sakovich V. A. , Shabanov V. V. , Artemenko S. N. , Romanov A. B. , Pokushalov Ye. A. , Ivanitskiy E. A. , Kropotkin Ye. B. , Drobot D. B.
Published: July 2017

3 clinical cases of idiopathic ventricular tachyarrhthmias located in the right ventricular apex area are analyzed.
Comparison of Bioactive Compounds of Matricaria recutita Extracted by Ultrasound and Maceration and their Effects on Preventing Sunflower Oil During Frying
Authors: Farahmandfar Reza , Asnaashari Maryam , Asadi Yegane , Beyranvand Batool
Published: July 2017

Background: It is important to study about the use of natural antioxidants as alternatives to
synthetic ones due to the possibility of carcinogenic effects of synthetic antioxidants. This study is
comparing the effect of the ultrasound-assisted and maceration extraction methods on antioxidant activity
of Matricaria recutita.

Methods:

Bioactive compounds including phenolic, tocopherol, flavonoid and tannins and antioxidant
activity of the extracts were evaluated. Moreover, extracts obtained from ultrasound and maceration
methods were added to sunflower oil without any antioxidants at level of 200, 500 and 800 ppm, after
that samples were heated at 180°C. Oxidation of the samples were evaluated after 0, 4, 8, 12, 16, 20
and 24 hours by measuring Peroxide Value (PV), Conjugated Diene (CD), Iodine Value (IV), Carbonyl
Value (CV), Total Polar Compounds (TPC), Oil Stability Index (OSI), Color Index (CI) and acid
value (AV).

Results:

The result showed total phenol (42.90 mg gallic acid/g extract), tocopherol (120.46 µg α -
tocopherol/ml extract), flavonoid (2.64 mg/100 g extract) and tannins (3.89 mg gallic acid/g extract)
of ultrasound extracts were higher than maceration extracts. Antioxidant activity of the extract was
evaluated by DPPH assay which indicated 800 ppm of the Matricaria recutita extracted by ultrasound
was the highest radical scavenging ability.

Conclusion:

Result indicated both ultrasound and maceration extracts could increase the oil oxidative
stability but could not increase compared to BHA. In most cases, the extract samples by ultrasound
had a better effect on stabilizing of sunflower oil during frying.
A Stronger Theorem Against Macro-realism
Authors: Allen John-Mark A. , Maroney Owen J. E. , Gogioso Stefano
Published: July 2017

Macro-realism is the position that certain macroscopic observables must always possess definite values: e.g. the table is in some definite position, even if we do not know what that is precisely. The traditional understanding is that by assuming macro-realism one can derive the Leggett-Garg inequalities, which constrain the possible statistics from certain experiments. Since quantum experiments can violate the Leggett-Garg inequalities, this is taken to rule out the possibility of macro-realism in a quantum universe. However, recent analyses have exposed loopholes in the Leggett-Garg argument, which allow many types of macro-realism to be compatible with quantum theory and hence violation of the Leggett-Garg inequalities. This paper takes a different approach to ruling out macro-realism and the result is a no-go theorem for macro-realism in quantum theory that is stronger than the Leggett-Garg argument. This approach uses the framework of ontological models: an elegant way to reason about foundational issues in quantum theory which has successfully produced many other recent results, such as the PBR theorem.
QCMA hardness of ground space connectivity for commuting Hamiltonians
Authors: Gosset David , Mehta Jenish C. , Vidick Thomas
Published: July 2017

In this work we consider the ground space connectivity problem for commuting local Hamiltonians. The ground space connectivity problem asks whether it is possible to go from one (efficiently preparable) state to another by applying a polynomial length sequence of 2-qubit unitaries while remaining at all times in a state with low energy for a given HamiltonianH. It was shown in [Gharibian and Sikora, ICALP15] that this problem is QCMA-complete for general local Hamiltonians, where QCMA is defined as QMA with a classical witness and BQP verifier. Here we show that the commuting version of the problem is also QCMA-complete. This provides one of the first examples where commuting local Hamiltonians exhibit complexity theoretic hardness equivalent to general local Hamiltonians.
Three-dimensional alteration of constricted alveolar ridge affected by root thrusting with and without open-flap decortication
Authors: Hwang Donghyun , Lee Won-June , Kim Kyung-A , Baek Seung-Hak , Park Young-Guk , Kim Su-Jung
Published: July 2017

Objective:

To investigate the morphometric and histological alterations of the constricted alveolar ridge when affected by root thrusting with and without open-flap decortication.

Materials and Methods:

Eight beagles were divided into three groups: C, control without root thrusting; R, root thrusting only; RD, root thrusting with alveolar decortication. The ridge constriction model was prepared in 16 mandibular quadrants after extraction of the third premolars. Reciprocal root thrusting of the second and fourth premolars was performed toward the constricted ridge for 10 weeks, having a moment of 900 g-mm. Open-flap decortication was conducted on the constricted bone surface in group RD. Micro-CT-based histomorphometric analysis and trichrome-staining-based tissue fractional analysis were performed to evaluate morphometric and microstructural changes on the ridge.

Results:

Group R revealed a higher percentage of bone volume (P < .001), lower bone mineral density (P < .01), and higher trabecular number (P < .001) than did group C, which was supported by a higher bone fraction woven to lamellar bone (P < .05) resulting from histologic fractional analysis. However, group RD showed no significant difference from group C.

Conclusions:

Root thrusting toward the constricted ridge induced hypertrophic bone modeling with a high trabecular fraction on the ridge. However, combined open-flap decortication with root thrusting did not improve the volume or quality of the constricted ridge.
A Near Visual Acuity Test for Dentists
Authors: Perrin P , Eichenberger M , Neuhaus KW , Lussi A
Published: July 2017

Unimpaired near vision is crucial in dentistry, but appropriate visual tests at dental working distance are not publicly available. The aim of this study was to validate a novel visual triage test for dentists that is easy to use and freely available. The near visual acuity at 300 mm of 106 dental professionals (aged 21–65 years) was assessed with 1) a validated near visual test for scientific purposes miniaturized on a microfilm; 2) an experimental test using a US $5 bill, in which the first five words of each line in the Lincoln Memorial frieze had to be read under a dental operating light. The Spearman rank correlation coefficient of 0.784 revealed a strong correlation between the two tests (p<0.0001). The ability to read six or more words in the memorial frieze meant there was a 94% chance of having a validated near visual acuity greater than or equal to the median score of the dentists tested. If none of the words could be read, the chance of having a near visual acuity below the median of the peer group was 89%. The influence of the dentists' age and experience on their visual performance reported in former studies was corroborated with this new test. The US $5 bill offers a simple and easily available near visual test to rank individuals' near vision relative to that of other dentists and to recognize the progression of presbyopia with increasing age.
Julkaisupaine suomalaisessa tiedeyhteisössä
Authors: Pölönen Janne , Auranen Otto
Published: July 2017

Performance-based research funding systems are often assumed to create an increasing pressure to publish among academics. Presumption is that national level incentives put pressure on researchers to increase quantity of publishing at the expense of quality. In Finland publications have been a criterion in the government’s basic funding model for universities since 2007. We analysed national personnel and publication data on Finnish universities, and found that the average publication productivity among Finnish university staff has not increased from 1998 to 2016. We also looked at the Web of Science publications in 1998-2014, and found that publication productivity of academics is not exceptionally high in Finland, compared to Sweden, Denmark and Norway. Citation impact has not remarkably decreased in Finland compared to the other Nordic countries. In our view, the experience of pressure to publish is also, and perhaps primarily, due to competition for research funding and academic positions partaken by an increasing number of researchers.
MaRIS - Migration and Refugee Information Studies Research Project
Authors: Eskola Eeva-Liisa , Hämäläinen Riitta , Ojanperä Anne , Ruokolainen Hilda
Published: July 2017

According to the statistics of the United Nations High Commissioner for Refugees (UNHCR 2017) from 2015 there were 65.3 million forcibly displaced people around the world. Global migration can be expected to be a large question in the world also in the future, for example, the recent refugee and asylum seekers crises in Europe brought with it a number of challenges on many levels. One of the major challenges is connected to communication and information. The goal of the MaRIS project is to strengthen the research in the area of refugee information practices, needs, seeking and use, as well as to promote dialogue and collaboration between the researchers and the practitioners interested in the topic.
Kotimaiset tieteelliset lehdet, rinnakkaistallennus sekä huomioita SHERPA/RoMEOsta
Authors: Ylönen Irene , Lilja Johanna , Holopainen Mika
Published: July 2017

This report examines the actions taken for promoting the green OA in Finnish scholarly journals and their effects in 2016 and 2017. A Finnish-language form for suggesting publisher policies to SHERPA/RoMEO database was developed. It was linked into instructions for applying the government subsidy of scholarly publishing. Finally, a resolution on archiving was negotiated with the copyright organization responsible for distributing remunerations of a national license based article database (Elektra). Due to these actions, the number of announced self-archiving policies rose from 27 to 53. 24 policies were collected via the Finnish form and sent to SHERPA/RoMEO. In this connection, some shortages in SHERPA/RoMEO service were noted. First, relaying the publishers’ policies to service is not a quick procedure. It took approximately 6–7 weeks to get new policies and updates through to the database. Secondly, the metadata in SHERPA/RoMEO may cause problems because it is not stored in any structured way. Especially, the widely used colour code system is problematic.