bluuebunny/crossref_metadata_2025 huggingface dataset:
Palliative Radiotherapy for Bleeding from Unresectable Gastric Cancer Using Three-Dimensional Conformal Technique
Authors: Kawabata Hideaki , Fujii Takashi , Yamamoto Tetsuya , Satake Hiroaki , Yamaguchi Katsutoshi , Okazaki Yuji , Nakase Kojiro , Miyata Masatoshi , Motoi Shigehiro
Published: June 2022

Optimal regimens using recent radiotherapy (RT) equipment for bleeding gastric cancer (GC) have not been fully investigated yet. We retrospectively reviewed the clinical data of 20 patients who received RT for bleeding GC in our institution between 2016 and 2021. Three-dimensional conformal RT was performed. The effectiveness of RT was evaluated by the mean serum hemoglobin (Hb) level and the number of transfused red blood cell (RBC) units 1 month before and after RT. The median first radiation dose was a BED of 39.9 Gy. The treatment success rate was 95% and the rebleeding rate was 10.5%. There was a significant increase in the mean Hb level (8.0 ± 1.1 vs. 9.8 ± 1.3 g/dL, p = 0.01), and a significant decrease in the mean number of transfused RBC units (6.8 ± 3.3 vs. 0.6 ± 1.5 units, p < 0.01). Severe toxicity was observed in two patients (anorexia [n = 1] and gastrointestinal [GI] perforation [n = 1]). Reirradiation was attempted in three patients (for hemostasis [n = 2] and for mass reduction [n = 1]). The retreatment success rate for rebleeding was 100%. GI perforation occurred in two patients who had received hemostatic reirradiation. Palliative RT for bleeding GC using recent technology had excellent efficacy. However, it may be associated with a risk of GI perforation.
Expression of Apoptosis-Related Biomarkers in Inflamed Nasal Sinus Epithelium of Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)—Evaluation at mRNA and miRNA Levels
Authors: Morawska-Kochman Monika , Śmieszek Agnieszka , Marcinkowska Klaudia , Marycz Krzysztof Mariusz , Nelke Kamil , Zub Krzysztof , Zatoński Tomasz , Bochnia Marek
Published: June 2022

In chronic upper respiratory tract diseases, increased cell proliferative activity is observed, which is coordinated by BCL-2 proteins and small non-coding RNAs. This study aimed to determine the expression of critical apoptosis markers at the mRNA and miRNA levels in patients with chronic rhinosinusitis with nasal polyps (CSRwNP). The study group consisted of ten patients with CSRwNP and ten healthy subjects. To detect in situ apoptosis in the maxillary sinus mucosa, TUNEL staining was performed. The expression of transcripts was determined by RT-qPCR and included the detection of markers associated with cell survival and apoptosis, i.e., BAX, p53, p21, CASP3, CASP9, c-MYC, CCND1, BRIC5, and APAF1. Levels of miR-17-5p, miR-145-5p, miR-146a-5p, and miR-203a-3p were also measured by RT-qPCR. The obtained results indicated increased apoptosis determined by a TUNEL assay in CSRwNP patients and accompanied by an increased expression of BAX, P21, P53, CASP3, CASP9, c-MYC, and APAF-1 transcripts and decreased mRNA levels of BCL-2 and BIRC5. Furthermore, the nasal sinus epithelium of patients with CSRwNP showed increased levels of miR-203a-3p while also showing a decreased expression of miR-17-5p and miR-145-5p. Our results showed that pro-apoptotic transcripts detected at mRNA and miRNA levels might be involved in the pathogenesis of chronic sinusitis with polyps. The identification of those key molecular mediators may be applicable for the specific diagnostic and/or development of targeted therapies for chronic sinusitis with polyps.
Application of Artificial Intelligence in the Management of Pancreatic Cystic Lesions
Authors: Rangwani Shiva , Ardeshna Devarshi R. , Rodgers Brandon , Melnychuk Jared , Turner Ronald , Culp Stacey , Chao Wei-Lun , Krishna Somashekar G.
Published: June 2022

The rate of incidentally detected pancreatic cystic lesions (PCLs) has increased over the past decade and was recently reported at 8%. These lesions pose a unique challenge, as each subtype of PCL carries a different risk of malignant transformation, ranging from 0% (pancreatic pseudocyst) to 34–68% (main duct intraductal papillary mucinous neoplasm). It is imperative to correctly risk-stratify the malignant potential of these lesions in order to provide the correct care course for the patient, ranging from monitoring to surgical intervention. Even with the multiplicity of guidelines (i.e., the American Gastroenterology Association guidelines and Fukuoka/International Consensus guidelines) and multitude of diagnostic information, risk stratification of PCLs falls short. Studies have reported that 25–64% of patients undergoing PCL resection have pancreatic cysts with no malignant potential, and up to 78% of mucin-producing cysts resected harbor no malignant potential on pathological evaluation. Clinicians are now incorporating artificial intelligence technology to aid in the management of these difficult lesions. This review article focuses on advancements in artificial intelligence within digital pathomics, radiomics, and genomics as they apply to the diagnosis and risk stratification of PCLs.
DNA Methylation Biomarkers for Prediction of Response to Platinum-Based Chemotherapy: Where Do We Stand?
Authors: Tavares Nuno Tiago , Gumauskaitė Saulė , Lobo João , Jerónimo Carmen , Henrique Rui
Published: June 2022

Platinum-based chemotherapy is routinely used for the treatment of several cancers. Despite all the advances made in cancer research regarding this therapy and its mechanisms of action, tumor resistance remains a major concern, limiting its effectiveness. DNA methylation-based biomarkers may assist in the selection of patients that may benefit (or not) from this type of treatment and provide new targets to circumvent platinum chemoresistance, namely, through demethylating agents. We performed a systematic search of studies on biomarkers that might be predictive of platinum-based chemotherapy resistance, including in vitro and in vivo pre-clinical models and clinical studies using patient samples. DNA methylation biomarkers predictive of response to platinum remain mostly unexplored but seem promising in assisting clinicians in the generation of more personalized follow-up and treatment strategies. Improved methodologies for their detection and quantification, including non-invasively in liquid biopsies, are additional attractive features that can bring these biomarkers into clinical practice, fostering precision medicine.
Investigation of the Microstructure of Fine-Grained YPO4:Gd Ceramics with Xenotime Structure after Xe Irradiation
Authors: Mikhaylov Dmitriy A. , Potanina Ekaterina A. , Nokhrin Aleksey V. , Orlova Albina I. , Yunin Pavel A. , Sakharov Nikita V. , Boldin Maksim S. , Belkin Oleg A. , Skuratov Vladimir A. , Issatov Askar T. , Chuvil’deev Vladimir N. , Tabachkova Nataliya Y.
Published: June 2022

This paper reports on the preparation of xenotime-structured ceramics using the Spark Plasma Sintering (SPS) method. Y0.95Gd0.05PO4 (YPO4:Gd) phosphates were obtained using the sol-gel method. The synthesized powders were nanodispersed and were agglomerated (the agglomerates sizes were 10–50 µm). The ceramics had a fine-grained microstructure and a high relative density (98.67 ± 0.18%). The total time of the SPS process was approximately 18 min. The sintered high-density YPO4:Gd ceramics with a xenotime structure were irradiated with 132Xe+26 ions with 167 MeV of energy and fluences in the range of 1 × 1012–3 × 1013 cm−2. Complete amorphization was not achieved even at the maximum fluence. The calculated value of the critical fluence was (9.2 ± 0.1) × 1014 cm−2. According to the results of grazing incidence X-ray diffraction (GIXRD), the volume fraction of the amorphous structure increased from 20 to 70% with increasing fluence from 1 × 1012 up to 3 × 1013 cm−2. The intensity of the 200 YPO4:Gd XRD peak reached ~80% of the initial intensity after recovery annealing (700 °C, 18 h).
The Impact of a Rater Training Program on the TGMD-3 Scoring Accuracy of Pre-Service Adapted Physical Education Teachers
Authors: Kwon Hyunjin , Maeng Hyokju
Published: June 2022

This study aimed to examine the impact of a TGMD-3 rater training program on pre-service adapted physical education (APE) teachers’ ability to score fundamental motor skills for children with developmental disabilities (DD). The training program consisted of a description of the TGMD-3 instrument and DD, as well as content focused on skill performance and correct scoring through systematic analysis of 13 FMS via the instrument. Three experts established the standard score through the TGMD-3 performance evaluation of a child with DD. Thirty-nine pre-service APE teachers in the experimental group and 30 pre-service teachers in the control group completed the pre- and post-test process in this study. There were significant impacts on the pre-service teachers’ ability to score the locomotor, ball skill subtests, and total skill scores (p < 0.05) compared to the control group. Specifically, the results of the three locomotor skills (running, horizontal jump, & slide) and three ball skills (two-hand strike, dribble, & kick) significantly improved in scoring accuracy. The results of this study can evidence that a TGMD-3 rater training program for pre-service APE teachers enhances the scoring accuracy of FMS among children with DD.
SC Wall-to-RC Basemat Over-Strength Connection: Behavior and Design
Authors: Kurt Efe G. , Seo Jungil , Varma Amit H.
Published: June 2022

This paper presents results from experimental and analytical investigations conducted to evaluate the lateral load behavior and capacity of steel-plate composite (SC) wall-to-reinforced concrete (RC) basemat connections. Two SC wall-to-reinforced concrete basemat connection specimens were tested. These SC wall specimens had a height-to-length ratio of 0.6 and did not include boundary elements. The experimental results include the lateral force-displacement (V-Δ) responses of the specimens and observations of local damage such as steel plate local buckling and concrete crushing. 3D finite element models were developed and benchmarked using the experimental results. The benchmarked models were used to conduct analytical parametric studies, expand the database, and gain additional insights into the behavior of SC wall-to-RC basemat connections. The parameters included in analytical investigations were the wall aspect ratio (h/lw), reinforcement ratio (ρ), and wall thickness (T).
Effective Field Theory of Random Quantum Circuits
Authors: Liao Yunxiang , Galitski Victor
Published: June 2022

Quantum circuits have been widely used as a platform to simulate generic quantum many-body systems. In particular, random quantum circuits provide a means to probe universal features of many-body quantum chaos and ergodicity. Some such features have already been experimentally demonstrated in noisy intermediate-scale quantum (NISQ) devices. On the theory side, properties of random quantum circuits have been studied on a case-by-case basis and for certain specific systems, and a hallmark of quantum chaos—universal Wigner–Dyson level statistics—has been derived. This work develops an effective field theory for a large class of random quantum circuits. The theory has the form of a replica sigma model and is similar to the low-energy approach to diffusion in disordered systems. The method is used to explicitly derive the universal random matrix behavior of a large family of random circuits. In particular, we rederive the Wigner–Dyson spectral statistics of the brickwork circuit model by Chan, De Luca, and Chalker [Phys. Rev. X 8, 041019 (2018)] and show within the same calculation that its various permutations and higher-dimensional generalizations preserve the universal level statistics. Finally, we use the replica sigma model framework to rederive the Weingarten calculus, which is a method of evaluating integrals of polynomials of matrix elements with respect to the Haar measure over compact groups and has many applications in the study of quantum circuits. The effective field theory derived here provides both a method to quantitatively characterize the quantum dynamics of random Floquet systems (e.g., calculating operator and entanglement spreading) and a path to understanding the general fundamental mechanism behind quantum chaos and thermalization in these systems.
Investigation of Oil and Facility Characteristics of Plastic Waste Pyrolysis for the Advanced Waste Recycling Policy
Authors: Namkung Hueon , Park Se-In , Lee Yoomin , Han Tae Uk , Son Jun-Ik , Kang Jun-Gu
Published: June 2022

Alternative chemical and fuel oil produced from plastic waste may play a key role in national sustainable development. The Korean government has promoted several waste recycling policies including waste to energy. Here, we focus on the investigation of the oil and facility characteristics of plastic waste pyrolysis. Four pyrolysis facilities, which had different pyrolysis processes and produced various oil properties, were chosen in order to develop an advanced waste recycling policy. Pyrolysis oil recovery efficiency and chemical characteristics were influenced by feedstock and pyrolysis conditions. In terms of pyrolysis gases, the gas quantity was different due to the pyrolyzer operation conditions, but the characteristics of gas composition were not especially distinguished. In addition, air pollutants, such as carbon monoxide (CO), nitrogen oxides (NOx), sulfur oxides (SOx), and hydrogen sulfide (H2S) from the pyrolysis process were analyzed to evaluate the environmental effects on the surrounding area. The air pollutant concentration varied, but those from the process were adequately controlled. From the aforementioned results, several improvements have been deduced to manage the pyrolysis oil facility and product in advanced policy decisions.
Energy Consumption Forecasting for the Digital-Twin Model of the Building
Authors: Henzel Joanna , Wróbel Łukasz , Fice Marcin , Sikora Marek
Published: June 2022

The aim of the paper is to propose a new approach to forecast the energy consumption for the next day using the unique data obtained from a digital twin model of a building. In the research, we tested which of the chosen forecasting methods and which set of input data gave the best results. We tested naive methods, linear regression, LSTM and the Prophet method. We found that the Prophet model using information about the total energy consumption and real data about the energy consumption of the top 10 energy-consuming devices gave the best forecast of energy consumption for the following day. In this paper, we also presented a methodology of using decision trees and a unique set of conditional attributes to understand the errors made by the forecast model. This methodology was also proposed to reduce the number of monitored devices. The research that is described in this article was carried out in the context of a project that deals with the development of a digital twin model of a building.
Multi-Time Period Optimal Dispatch Strategy for Integrated Energy System Considering Renewable Energy Generation Accommodation
Authors: Yu Chutian , Lai Xinyi , Chen Fei , Jiang Chenwei , Sun Yikai , Zhang Lijun , Wen Fushuan , Qi Donglian
Published: June 2022

With the target of carbon peaking and carbon neutrality, renewable energy generation (REG) develops rapidly. The increasing penetration of REG brings along the problems of fluctuation in power flow and the possible abandonment of wind and photovoltaics (PV) generation. In this context, the so-called integrated energy system (IES) becomes a promising solution to the accommodation of REG thanks to energy storage systems and coupling devices inside. In this paper, the optimal operation model of an IES is first presented, with the schemes of green certificate trading and carbon emission right trading included to provide economic incentives for accommodating REG. Next, in order to address the problem of uncertainty in REG, the devices in the IES are divided into three types based on regulation flexibility, and a multi-time period optimal dispatching scheme is proposed, including day-ahead optimal scheduling, rolling optimal dispatching, and real-time control strategy. Finally, it is demonstrated by simulation results of a numerical example that the proposed method not only promotes the accommodation capability for REG but can also cope well with contingencies.
Numerical Investigation of the Influence of Air Contaminants on the Interfacial Heat Transfer in Transonic Flow in a Compressor Rotor
Authors: Wiśniewski Piotr , Zhang Guojie , Dykas Sławomir
Published: June 2022

Atmospheric air is a commonly used working fluid in turbomachinery. The air typically contains a certain amount of suspended solid particles, as well as water in the form of vapor or droplets. In the current paper, we focus on the numerical modeling of humid air transonic flow in turbomachinery. In this paper we demonstrate a rarely considered, but as presented herein important influence of air humidity, pollution and liquid water content on the performance of the first stage of the gas turbine compressor and turbofan engine fan (NASA rotors 37 and 67). We also discuss the impact of the interfacial heat transfer associated with steam condensation or water evaporation on the distribution of stagnation parameters at the rotor outlet, the rotor performance, and flow conditions, as well as losses. Results demonstrate the impact of the number of pollution particles and water droplets on the compression process in the analyzed rotors, especially on the Mach number distribution in the blade-to-blade channel. In this paper we highlight that the air pollution and liquid water content, together with such physical phenomena as steam condensation or water droplets evaporation, exert a significant influence on work parameters, losses and efficiency, and thus should be considered in high-velocity airflow simulations.
Experimental Investigation of Two-Phase Flow Boiling Heat Transfer Coefficient and Pressure Drop of R448A inside Multiport Mini-Channel Tube
Authors: Hoang Hieu Ngoc , Agustiarini Nurlaily , Oh Jong Taek
Published: June 2022

Regulations and restrictions against high global warming potential (GWP) refrigerants have been introduced to encourage the adoption of environmentally friendly refrigerants and mitigate the environmental impact of the HVAC industry. R448A, a zeotropic blend with a GWP of 1390, has recently been proposed as a drop-in replacement for R404A and R410A in commercial systems. In this study, the heat transfer coefficient and pressure drop characteristics of R448A within a multiport mini-channel tube were experimentally investigated. The experimental ranges of the mass and heat fluxes were 100 to 500 kg/(m2s) and 3–15 kW/m2, respectively. Additionally, the range of quality from 0 to 1 was considered at two fixed saturated temperatures of 3 and 6 °C. The heat transfer coefficient increased with mass flux. Under low mass flux condition, the heat flux increased the heat transfer coefficient, but there was no noticeable effect of the saturated temperature on the heat transfer coefficient. At high mass flux, heat flux had no major effect on heat transfer, while a decrease in the saturated temperature was found to increase the heat transfer coefficient. Moreover, the pressure drop increased with an increase in the mass flux and vapor quality, whereas the heat flux did not affect the pressure drop. The heat transfer coefficient and pressure drop performance of R448A was compared with that of R410A inside the same tube. Finally, correlations for heat transfer coefficient and pressure drop were proposed for the prediction of heat transfer coefficient and pressure drop in practical applications.
Perspectives of Biodiesel Development in Poland against the Background of the European Union
Authors: Bórawski Piotr , Holden Lisa , Bórawski Marek Bartłomiej , Mickiewicz Bartosz
Published: June 2022

Biofuels are becoming more important in the renewable energy sources mix. Liquid biofuels are products of agriculture. Bioethanol can be prepared from corn, beetroot and other plants. Biodiesel is mainly made from rapeseed. This paper presents information about biodiesel development in Poland, as well as some background information about its development in the European Union (EU). We analyzed the data about biofuels in the literature, and provide statistical data about liquid biofuel in Poland and other countries of the EU. The aim of the study is to assess the viability of liquid biofuel development in Poland. The base for biodiesel production in Poland and the EU is rapeseed. The production yields and sown area of rapeseed increased in Poland from 2005–2020. This was due to integration and European Union policies which aim to supply clean energy. The energy mix in Poland differs from that of the EU. Solid biofuels have made up the biggest share of renewable energy sources in Poland (73.4%) and the EU (40.1%). Poland has smaller share of wind energy, biogas, heat pump, water energy, solar anergy, municipal waste and geothermal energy in its renewable energy sources compared to the rest of the EU. Only with solid and liquid biofuels is the share of renewable energy sources larger in Poland compared to the EU averages. Poland has decreased its share of solid biofuels and water energy among its renewable energy sources, while other sources have increased. Poland is investing to increase its renewable energy sources. To analyze the opportunities for biodiesel production in Poland, we used the scenario method of analysis. We outlined three scenarios. The first is increasing the production of biodiesel by 3% each year for the next three years. The second is production remains unchanged, i.e., at the 2020 level. The last scenario is decreasing production by 3% each year. According to the first scenario, the total demand for rapeseed for energy and food purposes will be 375 thousand tons in 2025. Such a scenario is very likely to occur because of the growing demand for biodiesel and edible oil. The current situation with Ukraine and the Russian Federation will create an increase in demand for rapeseed, leading to higher prices.
Modified Particle Swarm Optimization with Attention-Based LSTM for Wind Power Prediction
Authors: Sun Yiyang , Wang Xiangwen , Yang Junjie
Published: June 2022

The accuracy of wind power prediction is crucial for the economic operation of a wind power dispatching management system. Wind power generation is closely related to the meteorological conditions around wind plants; a small variation in wind speed could lead to a large fluctuation in the extracted power and is difficult to predict accurately, causing difficulties in grid connection and generating large economic losses. In this study, a wind power prediction model based on a long short-term memory network with a two-stage attention mechanism is established. An attention mechanism is used to measure the input data characteristics and trend characteristics of the wind power and reduce the initial data preparation process. The model effectively alleviates the intermittence and fluctuation of meteorological conditions and improves prediction accuracy significantly. In addition, the modified particle swarm optimization algorithm is introduced to optimize the hyperparameters of the LSTM network, which speeds up the convergence of the model dramatically and avoids falling into local optima, reducing the influence of man-made random selection of LSTM network hyperparameters on the prediction results. The simulation results on the real wind power data show that the modified model has increased prediction accuracy compared with the previous machine learning methods. The monitoring and data collecting system for wind farms reveals that the accuracy of the model is around 95.82%.
Design and Testing of a Multimode Capable Passive Battery Management System
Authors: Pelin Denis , Brandis Andrej , Kovačević Mario , Halak Filip
Published: June 2022

A customized passive battery management system (BMS), which offers a selection of different operating configurations regarding the connection of external sources and loads, has been developed. The device supports balance, charge, de-balance, discharge and permanent storage battery processes. The control unit is run by its own written algorithm (code). Suggestions for potential hardware and software changes that can be made to expand the capabilities of the device are listed. The device is tested in five different operating configurations and the output data (battery-cell voltages and balancing currents) are plotted in characteristic diagrams. The output data is analyzed and the unique capabilities of the device are explained. The detailed PCB design, code, and output measurement data files are included within the paper.
Sustainable Fashion—Rationale and Policies
Authors: Peleg Mizrachi Meital , Tal Alon
Published: June 2022

Sustainable fashion refers to efforts to minimize the fashion industry’s adverse environmental and social impacts. This entry describes the industry’s entire production chain: from polyester production, cotton growth and wasteful fashion consumption patterns to landfilling, where so many clothes end up. The entry characterizes the drivers behind the industry’s poor record regarding sustainability and employee exploitation, as well as new policies around the world designed to improve the industry’s performance These include the Australian Modern Slavery law, the French law prohibiting the destruction of textile surpluses and the New York Fashion Sustainability and Social Accountability Act.
Effects of Planting, Vegetation Management, and Pre-Commercial Thinning on the Growth and Yield of Lodgepole Pine Regenerated after Harvesting in Alberta, Canada
Authors: Dempster W. Richard
Published: June 2022

A large long-term field trial was established in the Upper and Lower Foothills sub-regions of the Canadian boreal forest to monitor the effects of planting, vegetation management, and pre-commercial thinning on the development of lodgepole pine stands following harvesting. Data collected at the end of the trial’s regeneration phase, 17 to 20 years after its establishment, were tested for treatment effects and projected to rotation age. Planting generally improved stocking and increased projected growth and yield of lodgepole pine. On modal sites, planted trees were often greatly outnumbered by natural regeneration; however, on others, typically with either poorer or richer soils, satisfactory restocking was not achieved without planting. Control of competing vegetation by herbicide application facilitated regeneration of pine where it was otherwise difficult or impossible on sites with excessive herbaceous or hardwood competition. Pre-commercial thinning accelerated the growth of individual trees and was projected to shorten rotations in dense stands. Responses to the treatments varied depending on environmental factors. Particular treatments may be effective to meet management objectives under some site conditions but unnecessary or counterproductive elsewhere.
Design and Characterization of a Novel Hapten and Preparation of Monoclonal Antibody for Detecting Atrazine
Authors: Xu Lingyuan , Abd El-Aty A.M. , Shim Jae-Han , Eun Jong-Bang , Lei Xingmei , Zhao Jing , Zhang Xiuyuan , Cui Xueyan , She Yongxin , Jin Fen , Zheng Lufei , Wang Jing , Jin Maojun , Hammock Bruce D.
Published: June 2022

This study provides the first design and synthetic protocol for preparing highly sensitive and specific atrazine (ATR) monoclonal antibodies (mAbs). In this work, a previously unreported hapten, 2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine, was designed and synthesized, which maximally exposed the characteristic amino group ATR to an animal immune system to induce the expected antibody. The molecular weight of the ATR hapten was 259.69 Da, and its purity was 97.8%. The properties of the anti-ATR mAb were systematically characterized. One 9F5 mAb, which can detect ATR, was obtained with an IC50 value (the concentration of analyte that produced 50% inhibition of ATR) of 1.678 µg/L for ATR. The molecular weight for the purified 9F5 mAb was approximately 52 kDa for the heavy chain and 15 kDa for the light chain. The anti-ATR mAb prepared in this study was the IgG1 type. The working range of the standard curve (IC20 (the concentration of analyte that produced 20% inhibition of ATR)—IC80 (the concentration of analyte that produced 80% inhibition of ATR)) was 0.384 to 11.565 µg/L. The prepared anti-ATR mAb had high specificity, sensitivity, and affinity with low cross-reactivity. The prepared anti-ATR mAb could provide the core raw material for establishing an ATR immunoassay.
Understanding the Relationship between Microstructure and Physicochemical Properties of Ultrafiltered Feta-Type Cheese Containing Saturea bachtiarica Leaf Extract
Authors: Alghooneh Ali , Alizadeh Behbahani Behrooz , Taghdir Maryam , Sepandi Mojtaba , Abbaszadeh Sepideh
Published: June 2022

Microwave-assisted extraction was optimized to prepare Satureja bachtiarica leaf (SBL) extract based on antimicrobial (IZD) and antioxidant activities (DPPH) and extraction yield (EY). At optimum condition, i.e., 800 W power and 8 min, the best extraction results with EY = 16%, IZD = 73.56 mm, and DPPH = 24.2% were obtained. To develop a novel Feta-cheese, the influence of SBL extract, rennet, and starter concentrations were evaluated in terms of rheological, textural, and sensorial properties. At the optimized condition, the acceptance, taste, the strength of the network (A), and the distance between sequential cross-linking points (ξ) were 8.13, 8.07, 34,036.12 Pa·s1/z, and 5.41 nm, respectively. At the 60th day of storage time, the lowest z value (the network extensity parameter) of the cheese samples was observed. SEM image texture indices showed a good correlation with the studied instrumental texture parameters during 60 days of storage. The mold and yeast counts and their growth rate in the SBL extract-added cheese were lower than those for control one; whereas, the former cheese showed a greater LAB population between the 80th and 120th days. The antimicrobial and antioxidant qualities of SBL extract showed a significant influence on cheese properties.
Estimating Shear Strength Properties of the Surrounding Soils Based on the Execution Energies of Piles
Authors: Ozelim Luan Carlos de Sena Monteiro , Ferrari de Campos Darym Júnior , Cavalcante André Luís Brasil , Camapum de Carvalho José , Silva Carlos Medeiros
Published: June 2022

Historically, empirical relations are the basis of everyday foundation design. These relations, however, rely on specific datasets, which may not represent the true conditions observed in the field. Even in situ tests rely on empirical correlation formulas, which link observed phenomena to soil properties. These correlations should be updated according to the specific design conditions. Big data (BD) workflows enable the use of massive data available to update the correlations and to provide more accurate predictions of the parameters studied. Thus, in this paper, a BD approach is used to study the relation between the drilling process of continuous flight auger piles and the shear strength properties (SSPs) of the surrounding soils. Soil surveys were carried out to identify the soil strata in the site and to validate the estimates of the SSPs. The results show that indirect measurements are in accordance with typical undrained shear strength and friction angles of the materials considered.
Prognosis of the Ipsilesional Corticospinal Tracts with Preserved Integrities at the Early Stage of Cerebral Infarction: Follow Up Diffusion Tensor Tractography Study
Authors: Jang Sung Ho , Seo Hye Rin , Byun Dong Hyun
Published: June 2022

This study examined the prognosis of the ipsilesional corticospinal tracts (CSTs) with preserved integrities at the early stage of cerebral infarction using follow-up diffusion tensor tractography (DTT). Thirty-one patients with a supratentorial infarction were recruited. DTT, Motricity Index (MI), modified Brunnstrom classification (MBC), and functional ambulation category (FAC) were performed twice at the early and chronic stages. The patients were classified into two groups based on the integrity of the ipsilesional CST on the second DTT: Group A (24 patients; 77.4%)—preserved integrity and Group B (7 patients; 22.6%)—disrupted integrity. No significant differences in MI, MBC, and FAC were observed between groups A and B at the first and second evaluations, except for FAC at the first evaluation (p > 0.05). MI, MBC, and FAC at the second evaluation were significantly higher than at the first evaluation in both groups A and B (p < 0.05). On the second DTT, one patient (4.2%) in group A showed a false-positive result, whereas five patients (71.4%) in group B had false-negative results. Approximately 20% of patients showed disruption of the ipsilesional CST at the chronic stage. However, the clinical outcomes in hand and gait functions were generally good. Careful interpretation considering the somatotopy of the ipsilesional CST is needed because of the high false-negative results on DTT at the chronic stage.
Intestinal Permeability Associated with the Loss of Skeletal Muscle Strength in Middle-Aged and Older Adults in Rural Area of Beijing, China
Authors: Li Cheng , Li Yaru , Wang Nan , Ge Zhiwen , Shi Zhengli , Wang Jia , Ding Bingjie , Bi Yanxia , Wang Yuxia , Hong Zhongxin
Published: June 2022

The association between intestinal permeability and sarcopenia remains unclear, and few studies have mentioned the relationship between intestinal permeability and skeletal muscle strength. The present cross-sectional community study was conducted in a rural area of Beijing to explore the association between intestinal permeability and handgrip strength (HGS) in middle-aged and older adults. Serum lipopolysaccharide (LPS), diamine oxidase (DAO) and D-lactate were detected to evaluate intestinal permeability. Gut microbiota (GM) and its potential interaction were also analyzed in the decision tree model. HGS was negatively correlated with DAO (r = −0.396, p < 0.01) in males. The negative association between HGS and DAO remained significant with the adjustment of covariates (β = −1.401, p < 0.05). Serum DAO and LPS were both negatively associated with HGS in middle-aged and older males, with the significant interactions of GM in the decision tree model, and D-lactate showed a negative association with HGS in females. Therefore, intestinal permeability was associated with the loss of skeletal muscle strength in middle-aged and older adults, and serum DAO may be a novel predictor for the loss of skeletal muscle strength in middle-aged and older males.
Effect of Salt Treatment on the Growth, Water Status, and Gas Exchange of Pyrus pyraster L. (Burgsd.) and Tilia cordata Mill. Seedlings
Authors: Paganová Viera , Hus Marek , Lichtnerová Helena
Published: June 2022

Two-year-old seedlings of T. cordata and P. pyraster were exposed to salinity for 50 days, whereby each plant was subject to regular applications of a substrate solution containing 100 mM NaCl, amounting to a cumulative volume of 365 mL per plant. The adaptive reactions of the tree species in coping with salt stress were studied. The measured parameters were the growth and distribution of mass to organs, root to shoot mass ratio (R:S), content of assimilation pigments in the leaves, gas exchange parameters (gs, E, An), and water use efficiency (WUE). The relative increase in biomass was reduced under salt treatment for both species. A significant decrease in the total FW and DW was observed only for T. cordata, which deposited 4.5 times more Na+ ions in the plant tissues compared with P. pyraster. In P. pyraster seedlings, Na+ ions mainly accumulated in the root (75%), and their distribution was limited to aboveground organs. Thus, a balanced content of the assimilation pigments in the leaves was maintained under salt treatment. In the initial (osmotic) phase of salt stress, P. pyraster reduced water consumption and maintained a steady rate of photosynthesis (An) per unit area. T. cordata responded to salinity by regulating stomatal conductance and increasing water use efficiency (WUE). T. cordata was not effective in blocking salt intake and transported Na+ ions to the leaves. Due to the high cumulative salt content in the substrate, the water potential of the leaf tissues and the rate of photosynthesis significantly decreased in salt-treated T. cordata seedlings. The results document the important role of the root system in the resistance of woody plants and in ensuring their survival in conditions of excessive salinity. The investment in root growth improved the water supply of P. pyraster seedlings and enhanced the retention of salt ions in the root system, thus limiting their transfer to leaves.
Heterogeneity of Cognitive Profiles in Children and Adolescents with Mild Intellectual Disability (MID)
Authors: Sajewicz-Radtke Urszula , Jurek Paweł , Olech Michał , Łada-Maśko Ariadna B. , Jankowska Anna M. , Radtke Bartosz M.
Published: June 2022

Mild Intellectual Disability (MID) is a neurodevelopmental disorder that begins in childhood and is characterized by limitations in intellectual functioning (IQ = 55–69) and adaptive behavior that manifests in everyday living. In addition to these specific criteria, clinical practice shows that the population of children with MID has heterogeneous deficits in cognitive functioning. Thus, the aim of this study was to identify groups of homogenous cognitive profiles within a heterogeneous population of students with MID. The cognitive profiles of 16,411 participants with Mild Intellectual Disability were assessed based on their performance on the Stanford–Binet Intelligence Scales–Fifth Edition. Prior to the assessment, participants were divided into three age groups corresponding to the levels of the Polish education system: (1) 7;00–9;11, (2) 10;00–14;11, and (3) 15;00–18;11 years old. Using cluster analysis, we identified three distinct cognitive profiles (clusters) in each age group. These clusters differed from each other within and between each age group. Distinguishing cognitive profiles among children and adolescents with MID is important both in the context of diagnosis as well as the development of research-based interventions for these students.
A Retrospective Cross-Sectional Study on the Risk of Getting Sick with COVID-19, the Course of the Disease, and the Impact of the National Vaccination Program against SARS-CoV-2 on Vaccination among Health Professionals in Poland
Authors: Kałucka Sylwia , Kusideł Ewa , Grzegorczyk-Karolak Izabela
Published: June 2022

Six months after starting the National Vaccination Program against COVID-19, a cross-sectional retrospective study was conducted among 1200 salaried and non-salaried healthcare workers (HCWs) in Poland. Its aim was to assess factors including the risk of exposure to COVID-19, experiences with COVID-19, the trust in different sources of knowledge about the pandemic and SARS-CoV-2 vaccines, and the government campaign on vaccination as predictors of vaccination acceptance. The strongest awareness of a high risk of work-associated infection was demonstrated by doctors (D) (72.6%) and nurses and midwives (N) (64.8%); however, almost half of the medical students (MS) and nursing and midwifery students (NS) did not identify as a risk group. Out of several dozen variables related to sociodemographic characteristics and personal experience of COVID-19, only occupation, previous COVID-19 infection, and high stress seemed to significantly influence vaccination acceptance. Interestingly, only 6.7% of respondents admitted that the government campaign impacted their decision to vaccinate. This result is not surprising considering that the vast majority of respondents (87.8%) learned about vaccinations from sources such as academic lectures (29.9%), health professionals (29.0%), or the internet (28.9%). Those who gained information about vaccination from traditional media (radio, television, and daily press), a popular platform of the government campaign, had a lower propensity to vaccinate (OR = 0.16, p < 0.001). Additionally, almost twice as many considered the information provided in the campaign to be unreliable. Our findings, from this retrospective study, do not confirm that the government campaign was effective for healthcare professionals. Therefore, in this group, other forms of vaccination incentives should be sought. However, the vaccinated respondents were significantly more likely to support compulsory vaccination against COVID-19 among health professionals.
Parasites of Selected Freshwater Snails in the Eastern Murray Darling Basin, Australia
Authors: Barton Diane P. , Zhu Xiaocheng , Nuhoglu Alara , Pearce Luke , McLellan Matthew , Shamsi Shokoofeh
Published: June 2022

Aquatic snails serve an important role in the ecosystem. They also play an essential role in the life cycle of many parasites as hosts and may pose risks to animal and human health. In Australia, the role of snails in the transmission of parasites of livestock is well studied. However, despite the country’s unique biodiversity and wildlife, little is known about the role of snails in the transmission and survival of parasites in other ecosystems, including aquatic and aquaculture systems. This study aimed to determine the occurrence of parasites in freshwater snails in the eastern Murray Darling Basin. A total of 275 snails were collected from various localities, including aquaculture fishery ponds and natural creeks during the summer and autumn months in the southern hemisphere. Three different species of freshwater snails, all common to the area, were found, including Bullastra lessoni (n = 11), Isidorella hainesii (n = 157), and Haitia acuta (n = 107), of which 9.1%, 1.3%, and 4.7%, respectively, were found to be harboring various developmental stages of Trematoda. No other parasite was found in the examined snails. Parasites were identified as Choanocotyle hobbsi, Plagiorchis sp. and Petasiger sp. based on the sequences of their ITS2, 18S, and 28S ribosomal DNA region. Herein, we report a native parasite Choanocotyle hobbsi in an introduced snail, Haitia acuta, from both natural and aquaculture ponds. As there are no genetic sequences for adult specimens of Petasiger spp. and Plagiorchis spp. collected in Australia for comparison, whether the specimens collected in this study are the larval stage of one of the previously described species or are a new, undescribed species cannot yet be determined. Our results also suggest snails collected from aquaculture ponds may be infected with considerably more parasites.
Electrostatic Spray Disinfection Using Nano-Engineered Solution on Frequently Touched Surfaces in Indoor and Outdoor Environments
Authors: Purwar Tanya , Dey Shamya , Al-Kayyali Osama Zaid Ali , Zalar Aaron Floyd , Doosttalab Ali , Castillo Luciano , Castano Victor M.
Published: June 2022

The COVID-19 pandemic has resulted in high demand for disinfection technologies. However, the corresponding spray technologies are still not completely optimized for disinfection purposes. There are important problems, like the irregular coverage and dripping of disinfectant solutions on hard and vertical surfaces. In this study, we highlight two major points. Firstly, we discuss the effectiveness of the electrostatic spray deposition (ESD) of nanoparticle-based disinfectant solutions for systematic and long-lasting disinfection. Secondly, we show that, based on the type of material of the substrate, the effectiveness of ESD varies. Accordingly, 12 frequently touched surface materials were sprayed using a range of electrostatic spray system parameters, including ion generator voltage, nozzle spray size and distance of spray. It was observed that for most cases, the surfaces become completely covered with the nanoparticles within 10 s. Acrylic, Teflon, PVC, and polypropylene surfaces show a distinct effect of ESD and non-ESD sprays. The nanoparticles form a uniform layer with better surface coverage in case of electrostatic deposition. Quantitative variations and correlations show that 1.5 feet of working distance, an 80 μm spray nozzle diameter and an ion generator voltage of 3–7 kV ensures a DEF (differential electric field) that corresponds to an optimized charge-to-mass ratio, ensuring efficient coverage of nanoparticles.
The Sport Training Process of Para-Athletes: A Systematic Review
Authors: Rodríguez Macías Manuel , Giménez Fuentes-Guerra Francisco Javier , Abad Robles Manuel Tomás
Published: June 2022

The aim of this systematic review was to identify the main factors affecting the training process of para-athletes, as well as the barriers they encounter. For this purpose, a systematic review was carried out in accordance with the PRISMA declaration guidelines, in which six databases were analysed (Web of Science, Scopus, SportDiscus, Pubmed, Eric, and PsycInfo). A total of 19 articles were selected for analysis after applying the inclusion criteria. The results show that the figures of the coach and families in the sporting and social contexts, respectively, had a relevant influence on the training process of para-athletes. Furthermore, in terms of psychological aspects, stress reduction, the importance of self-esteem, and motivation were highlighted. On the other hand, there are some barriers hindering the training and performance of athletes, which are related to the lack of financial support, lack of visibility in the media, and dependence on other people. These considerations can be of great help to coaches and competent institutions in the field (Paralympic committees, federations, etc.) in order to improve the training process and performance of para-athletes and to eliminate the barriers encountered by this group, promoting policies which facilitate access to sports for people with disabilities.
Innovation Capabilities in the Banking Sector Post-COVID-19 Period: The Moderating Role of Corporate Governance in an Emerging Country
Authors: Kien Cao Dinh , That Nguyen Huu
Published: June 2022

The COVID-19 pandemic is damaging economies across the world, including financial markets and institutions in all possible dimensions. For banks in particular, the pandemic generates multifaceted crises. This is likely to be worse in developing economies with poor financial market architecture. Innovation is considered an important factor in organizational effectiveness and competitive advantage post-COVID-19. Understanding how the banking system can improve their innovation capabilities is an unsolved question, especially in an emerging economy. Hence, this paper aims to examine the impact of capital budgeting, knowledge management, and business strategy on innovation capabilities in the Vietnamese banking sector post-COVID-19. More specifically, this study investigates the moderating role of corporate governance in strengthening these proposed impacts. This research uses a sample of 23 listed banks in Vietnam to examine the moderating role of corporate governance in the context of an emerging country. Hierarchical regression analysis and the multiple indicator approach are employed. The results indicate that knowledge management and business strategy significantly impact innovation capabilities while capital budgeting has no effect. Corporate governance has been revealed as the moderator of the relationship between two factors (knowledge management and business strategy) and innovation capabilities.