bluuebunny/crossref_metadata_2025 huggingface dataset:
The Utilization of Colonial Historical Sites in the City of Palembang as a Learning Resource Based on Outdoor Learning
Authors: Saputro Riki Andi
Published: June 2021

The activeness of all students’ senses can occur if students participate actively in learning activities. One of the learning activities that are able to actively involve students is by the way of outdoor learning. Research sub-focus: Cultural Heritage and Colonial Historical Sites. The formulation of the problem in this study: Historical value in the colonial period sites in the city of Palembang. The purpose of this research is to provide resource that can be used in learning History in High School. The benefit of this research is the availability of source and references for writing the history of the colonial period in Palembang. This research used history (historical) method, assisted by scientific approach from various fields (multi-approach) such as theological, political, anthropological and sociological sciences. The results of the research on colonial historical sites in the city of Palembang contain as a source of learning based on outdoor learning in high school.
Current Employment and Academic Status of Recent Dental Graduates in Dhaka City
Authors: Kabir Fuad Reajwan , Asaduzzaman AKM , Aktar Muqbula Tasrin , Islam Md Rafiqul , Kabir Md Fazlul , Samad Md Abdus , Hasan M Kumrul , Mim Zakia Siddiqa
Published: June 2021

This descriptive type of cross-sectional study was conducted with an objective to find out the present employment and academic status of recent dental graduates in Dhaka city. The study was conducted for one year from July 2019 to June 2020 at different work places of recent dental graduates and residence of unemployed dental graduates in Dhaka city. A total of 414 recent dental graduates were the respondents of the study. Study revealed that 212 (51.2%) of the respondents were male and 202 (48.8%) of the respondents were female. With regards to employment, it was revealed that 340 (82.1%) of the respondents were employed as dental surgeon and 57 (13.8%) of the respondents were yet to get formal employment. Among the employed dental graduates, 203 (57%) were full-time employee and 154 (47%) were part-time. Only 55 (15.4%) dental surgeons among them were working in government sector and rest were non-government employee or self-employed. Self-employment as a dental surgeon was the main source of income for 179 (43.2%) of total respondents. Regarding the job satisfaction, 139 (33.6%) were moderately satisfied and 182 (44%) were not satisfied with their pay standard. With regards to further academic engagement, 88 (21.2%) respondents were enrolled in different postgraduation courses whereas 205 (49.5%) of the respondents were also engaged in learning activities to get admitted into postgraduation courses. Study recommended that newly graduated dental surgeons could be utilized by engaging into both urban and rural areas by creating scope in both government and nongovernment sectors. Further academic engagement may be ensured by initiating new courses of dentistry and by increasing number of affiliated institutes for post-graduation.

Bangladesh Journal of Medical Education Vol.12(2) July 2021: 10-17
COVID-19 Infection in a 8 Day Old Neonate: Report of the 1st Case in a Term Neonate in Special Care Baby Unit (SCABU) at Dhaka Shishu (Children) Hospital
Authors: Zerin Israt Jahan , Hossain M Monir , Hoque Md Mahbubul
Published: June 2021

Abstract not available

DS (Child) H J 2020; 36(2): 163-165
Postgraduate Courses and Training in Paediatrics in BICH Vol 36(2)
Authors: Editor -
Published: June 2021

Abstract not available

DS (Child) H J 2020; 36(2): 175
Clinical Profile and Outcome of COVID-19 in Children at a Tertiary Hospital, Dhaka
Authors: Sultana Mahbuba , Chowdhury Sayla , Amin Abdullah Al
Published: June 2021

Background: Since the first detection on 8th March 2020 in Bangladesh, the number of cases is rising alarmingly. The paediatric population is also getting infected in Bangladesh. So far there is no study of COVID in children in this country.

Aim: This study reports on clinical profile, laboratory findings and outcomes of COVID-19 children admitted to Combined Military Hospital (CMH), Dhaka.

Materials and Methods: In this prospective observational study, RT-PCR confirmed fifty COVID-19 patients aged below twelve years were included. Relevant investigations were done in the Armed Forces Institute of Pathology (AFIP). Data were collected from patients and/or their attendants by a structured questionnaire.

Results: Mean age was 59.96±43.24 months, 48% were male and 52% were female. Predominant symptoms were fever (44%), cough (26%), anosmia (26%) and diarrhea (12%). There was neutropenia in 66% and lymphocytosis in 84% of cases. Mean neutrophil and lymphocyte counts were 38±13% and 52.5±13%, respectively. Significantly raised CRP observed in 14% and high serum procalcitonin was in10% of cases. Serum LDH, D-Dimer and ferritin were raised in 80%,34% and 6% of affected children, respectively. The majority (98%) of the children were improved and discharged from the hospital. One child died in this cohort.

Conclusion: Fever and cough were the predominant symptoms of COVID-19 affected children in this study. Lymphocytosis and neutropenia were two important laboratory finding. Death in COVID-19 is also not uncommon.

J Bangladesh Coll Phys Surg 2021; 39(3): 154-159
The Genetics of Autism Spectrum Disorder- A Review
Authors: Kundu Gopen Kumar , Islam Rumana
Published: June 2021

Autism spectrum disorder (ASD) is one of the most common neurodevelopmental disorders representing deficits in socialization, communication impairment, repetitive patterns of behaviors and/or restricted interest. The increasing prevalence of ASD worldwide is most likely due to increasing awareness, widening of the diagnostic concepts and availability of diagnostic framework. It is a genetically influenced disorders caused by factors including genetic, epigenetic factors that affect gene expression and activity and non-genetic factors like environmental exposures. It is widely thought to represent a disorder of connectivity, in which the environment interacts with the genome. It can occur as an association with genetic syndrome, can occur sporadically or may be familial. Recognizing various phenotypic manifestations, it is understood that the underlying etiology of ASD is complex and genetic factors play an important role. The most significant advance in autism biology over the last decade has been in understanding the genetics of autism. The genetic diagnosis can benefit patients and the family by providing information, psychological support both immediate and long term and also can guide and help to prepare for the future. So, genetic diagnosis of ASD may offer opportunities for the identification of molecular targets for novel interventions, and provide new insight for families seeking genetic counseling.

J Bangladesh Coll Phys Surg 2021; 39(3): 193-199
Reviewers in this Issue Vol 10(2)
Authors: Chief Editor in
Published: June 2021

Abstract not available

J Enam Med Col 2020; 10(2): 132
plagio como conducta que violenta la ética profesional e infracciona el derecho de autor
Authors: Atahuasi Chaparro Jesús
Published: June 2021

El presente trabajo de investigación tuvo como objetivo determinar la necesidad de establecer acciones remediales en relación a la incidencia de conductas académicas inadecuadas que constituyen una infracción a la ética profesional y a los derechos de autor en el proceso de formación inicial y continua universitaria. Para el efecto, se procedió a realizar un estado de la cuestión realizando un análisis de contenido de estudios procedentes de fuentes nacionales e internaciones. Por esta metodología es posible evaluar los niveles alcanzados por el problema propuesto en usuarios de una muestra de estudio, en este caso se consideró a los docentes y estudiantes de ambos sexos de la Universidad Latinoamericana CIMA de la ciudad de Tacna, observados durante los periodos lectivos 2017 y 2018. Las conclusiones sugieren que el plagio es una conducta que violenta la ética profesional del docente, ya que lesiona las dimensiones cognitivas: el pensamiento crítico; la dimensión personal-social: el prestigio y autoestima; y la dimensión: los valores de honestidad, integridad y el respeto de las ideas como la producción intelectual del otro.
Interpretation of 1D-Resistivity Data to Describe the Aquifer Model in the Serayu Watershed Area of Somagede Village, Somagede District, Banyumas Regency
Authors: Sehah Sehah , Hartono Hartono , Irayani Zaroh , Prabowo Urip Nurwijayanto , Apriyanto Fajar , Sagita Desty Maharani , Purnamasari Dwi
Published: June 2021

Acquisition of resistivity data using the Schlumberger configuration has been carried out in the Serayu watershed area of Somagede Village, Somagede District, Banyumas Regency. The purpose of this research was to describe a groundwater aquifer model based on the interpretation of 1D-resistivity data. The research results are resistivity logs of subsurface rock distributed over seven sounding points with resistivity values ranging from 2.24-192.78 m. The sounding points are located at positions of 7°31′28.55″ and 109°19′8.65″ (Sch-1) to 7°31′18.79″ and 109°19′21.45″ (Sch-7). The interpretation of the resistivity logs has resulted in a lithology log at each sounding point. Based on the interpretation, the lithology of the research area is composed of topsoil (42.85-85.13 m), sandy clay which partly slightly wet (7.08-17.18m), sandy clay inserted with gravel (22.44-31.70 m), sand, gravel, and pebble, with various consolidated (22.16-192.78m), sand inserted by gravel (6.77m), alternating sandstone and claystone, some of which are alternated with marl and tuff (8.71-21.99m), and sandstones with various porosity (3.25-8.76m). Shallow aquifers are interpreted to exist in sand inserted by gravel layer (13.23-27.67 m) at the sounding point of Sch-2 where the potential is quite good. While deep aquifers are estimated to be present in the sandstone layer with various porosity (> 46.67 m) at all sounding points with very good potential.Keywords: 1D-resistivity, Serayu watershed, resistivity log, aquifer, Somagede Village.
Can hydrogen enriched biogas be used as domestic fuel? - Part I – Thermal Characteristics of Blended Biogas/H2 Impinging Flames
Authors: Chen Yi , Kahangamage Udaya , Zhou Quan , Leung Chun Wah
Published: June 2021

Biogas is a renewable energy source widely produced by breakdowns of organic matters in natural environment and industry. However, it is not yet an ideal replacement of fossil fuels because its high CO2 content would deteriorate its thermal performance. To upgrade biogas for possible domestic application, hydrogen enrichment is proposed by adding high-grade hydrogen (H2) to biogas in order to improve its flammability and heating value, and reduce pollutant emission. However, most previous studies on blended Biogas/H2 focus on analysing the effects of H2 fraction and nozzle-to-plate distance on the heat flux profile and flame temperature. No comprehensive study has ever demonstrated the influence of the Reynolds number and equivalence ratio under a wide operating range. In this study, a test rig was built to investigate the effects of the Reynolds number and equivalence ratio on heat flux and thermal efficiency of blended biogas/H2 impinging flame. The blended biogas/H2 consisted of 80% biogas and 20% H2 addition in volume. Biogas was artificially made by 60% CH4 and 40% CO2 (BG60). The Reynolds number ranges from 300 to 1500 and equivalence ratio ranges from 1 to 3. A comparative study was also conducted between pure biogas (BG60) and biogas with 20% H2 enrichment.
Can hydrogen enriched biogas be used as domestic fuel? - Part II: Pollutants Emission from Combustion of Biogas/H2/air Fuel Mixture
Authors: Kahangamage Udaya , Chen Yi , Zhou Quan , Leung Chun Wah
Published: June 2021

Biogas is considered a sustainable source of energy which is largely untapped owing to its inherent weaknesses such as low thermal performance and potentially harmful emissions. Its thermal performance and emission characteristics can be enhanced through the technique of enriching with higher grade fuel. In this research study, biogas enriched with hydrogen was tested for its emission characteristics. A synthetic biogas identified as BG60 (60% CH4 and 40% CO2) enriched with 20% hydrogen (80%BG60-20%H2) was used for the test. Experiments were carried out for combustion of the enriched gas for a wide range of Reynolds numbers and equivalence ratios. The results indicate that the enriched fuel emits less CO and NOx than commonly used domestic fuel LPG. It also has a better thermal and emission performance than BG60. The low pollutant emissions compared with LPG, use of renewable feedstock for biogas production, and competitive cost may make the blended 80%BG60-20%H2 an attractive sustainable alternative domestic fuel choice for environmentally conscious urban dwellers of modern cities.
Thrombosis and severe acute respiratory syndrome coronavirus 2 vaccines: vaccine-induced immune thrombotic thrombocytopenia
Authors: Park Young Shil
Published: June 2021

The development of vaccines against severe acute respiratory syndrome coronavirus 2, which features high mortality and morbidity rates, has progressed at an unprecedented rate, and vaccines are currently in use worldwide. Thrombotic events after vaccination are accompanied by thrombocytopenia, and this issue was recently termed vaccine-induced immune thrombotic thrombocytopenia. This manuscript describes recently published guidelines and other related issues and demonstrates characteristic cases.
COMPONENT ANALYSIS FOR INTERESTING PATTERN DETECTION IN MULTI-VARIABLE DATA SETS
Authors: YÜCEL Ahmet
Published: June 2021

In recent years, great advances have been made on the concept of data, which has become the new power source of our age. Thanks to new methods and techniques at both coding and mechanical level, tremendous speeds have been achieved in the transfering, storing, and processing of data. Thanks to those digital developments, storing even the smallest information on digital platforms has become a natural part of daily life. From family photos to health history, from commercial records to academic publications, from a comment shared on Twitter to a video shared on Youtube, data in almost every field is stored instantly in different sizes. Interesting patterns and information in stored data waiting to be revealed are the main goals of data mining. In data mining studies, the size of data is one of the biggest problems encountered. Some of the problems encountered in large-scale data are the length of the processes of structuring such data and the jams that may occur during the execution of a model to be created afterward. Many dimension reduction algorithms have been developed to overcome the problems arising from large data sizes. In this study, a new dimension reduction approach has been developed on multivariate data. This approach generally consists of pattern recognition steps based on Principal Component Analysis (PCA). The created models were applied on disjoint and balanced sub-datasets and all produced significant results at the 0.05 confidence level. Explanatory performances of the models; They are in the range of [0.819, 0.888] on the multiple R-Square scale and in the range of [0.804, 0.878] on the R-Square scale.
YAPAY ZEKA İLE BİR EĞLENCE YAZILIMI: BENZEDİĞİN ÜNLÜ KİM?
Authors: EDİZ Çağla
Published: June 2021

Dijital çağda kullanılan yapay zekâ teknolojileri, tüm sektörlerde olduğu gibi dijital eğlence sektöründe de müşteri odaklı olarak hızlıca yapılandırılan kişiselleşmiş ürünlerin gelişmesine fırsat vermiştir. Bu kişiselleşmiş ürünler kısa süreli aidiyetler, üstgerçeklik, anlık tüketim hazları sağlama gibi dijital çağın postmodern istekleri gözetilerek oluşturulmaya çalışılır. Bu çalışma da, bu istekler gözetilerek hazırlanan ve gerçek zamanlı olarak oynanabilecek bir eğlence yazılım metodolojisi sunmaktadır. Hazırlanan uygulama çalıştığında, kameradan elde edilen yüz görüntüsü, bu yüze en çok benzeyen ünlünün yüz görüntüsü ve bu iki yüz arasında bir ara yüz görüntüsü ekranda görüntülenmektedir. Çalışmada kameradan elde edilen görüntüden gerçek zamanlı olarak yüz görüntüsünün bulunması için haar peşpeşe sınıflandırıcılarından faydalanıldı. Sonra elde edilen yüz görüntüsünün, eğitimde kullanılan ünlü yüz görüntüleri ile karşılaştırılması için özyüzler yöntemi kullanıldı. Son olarak görüntü işleme teknikleri kullanılarak ünlü ve kullanıcı yüzlerinin her ikisine de benzeyen bir yüz görüntüsü oluşturuldu. Böylece çalışmada, yaygın kullanılan yapay zeka algoritmalarıyla gerçek zamanlı olarak oynanabilecek ve farklı obje benzerlikleriyle çeşitlendirilebilecek bir kişiselleştirilmiş eğlence uygulama metodolojisinin sunulmaya çalışıldı.
Melagukan al-quran dengan langgam jawa: Studi Terhadap Pandangan Ulama Indonesia
Authors: Latifah Hanum Siti , Mursyid Ali
Published: June 2021

Beberapa tahun lalu dalam suatu forum, al-Qur‟an dibacakan dengan lagu (nada) atau langgam yang tidak biasa, yaitu langgam Jawa. Tentu saja ini langsung menuai polemik di kalangan para ulama di Indonesia. Ini tentu saja menarik untuk dikaji, sehingga menjadi rumusan masalah untuk diteliti antara lain: (1) siapa saja ulama yang kontra dengan membaca al-Qur‟an dengan langgam Jawa, apa dan bagaimana argumennya? (2) siapa saja ulama yang pro atau setuju dengan membaca al-Qur‟an dengan langgam Jawa, apa dan bagaimana argumennya? (3) bagaimana persamaan dan perbedaan di antara kedua kelompok ulama yang berbeda pandangan ini? Artikel ini dari kajian riset yang bersifat kualitatif dengan sumber data primer berupa pandangan para tokoh ulama yang terlibat dalam pro dan kontra mengenai melagukan al-Qur‟an dengan langgam Jawa. Ditemukan hasil riset berupa; Pertama, para ulama yang kontra dalam hal ini diantaranya: Prof. Dr. KH. Agil Husin Munawwar, M.A, Habib Riziq Syihab, M.A, Ust. H. Tengku Zulkarnain, Muammar ZA, dan Hj. Maria Ulfah, M.A, dengan alasan Al-Qur‟an adalah kitab suci Allah, tidak dapat dipadukan dengan langgam selain langgam yang telah disepakati jumhûr „ulama. Kedua, di anatara ulama al-Qur‟an yang pro terhadap langgam Jawa ini diantaranya: Dr. Ahsin Sakho Muhammad, M.A, Prof. Dr. Quraish Shihab, M.A, Prof. KH. Ali Mustafa Ya‟qub, dan M.A, Prof. Dr. KH. Ma‟ruf Amin, M.A dengan alasan boleh saja melagukan al-Qur‟an dengan langgam lain (Jawa) asalkan tidak keluar dari Tajwid yang benar dan tidak memaksakan langgam tersebut hingga menlanggar tajwid. Selain itu, ada juga ulama yang berpandangan moderat diantaranya Dr. KH. Ahmad Fathoni, Lc, M.A dan Romlah Widayati, dengan alasan melagukan al-Qur‟an dengan langgam apapun boleh, namun ini jangan dibesar-besarkan, dikhawatirkan akan merusak kaidah tajwid. Karena standar membaca al-Qur‟an itu tartil. Ketiga, persamaan kelompak yang setuju dan tidak setuju, sama-sama mengutamakan membaca al-Qur‟an dengan tajwid. Adapun perbedaannya, kelompok yang membolehkan al-Quran langgam Jawa, sebenarnya membolehkan dengan syarat tidak keluar dari aturan tajwid, sementara kelompok yang menolak langgam Jawa, adalah menolak langgam yang dapat menghinakan al-Qur‟an dan jika melanggar tajwid.
Early-life fitness trait variation among divergent European and North American farmed and Newfoundland wild Atlantic salmon populations
Authors: Islam SS , Wringe BF , Bøe K , Bradbury IR , Fleming IA
Published: June 2021

It has long been clear that interbreeding between domesticated and wild Atlantic salmon can lead to negative fitness consequences for native populations. Few studies, however, have examined these consequences at critical early life stages, particularly in the context of distinct geographical and ancestral relationships among populations as well domestication selection. In Newfoundland (NF), Canada, while the majority of aquaculture sites use the North American (NA) Saint John River strain, site-specific permission has been granted to farm a strain of European origin (EO). We designed a common-garden experiment to compare fitness-related traits (e.g. development time, survival, size and growth) at different early-life stages (eye development, hatch and yolk absorption) among EO and NA farmed, 2 NF wild and F1hybrid groups. Significant differences (p < 0.001) were observed in development time, survival, growth and energy conversion among farmed, F1hybrid and wild populations. While pure populations (farmed and wild) differed amongst one another, we found few differences in fitness-related traits between F1hybrids and their maternal wild/farmed strains. This suggests that the early-life fitness consequences of F1hybridization will be largely manifested through the action of maternal effects. Additionally, significant associations between the maternal effects of egg size and alevin development time, size, survival, growth, condition and energy conversion efficiency were found. These findings suggest that early-life fitness-related trait differences among farmed, wild and their related F1hybrids are generated by the geographic and ancestral relationship and maternal effects of egg size and less so by domestication selection.
Разработка и апробация математической модели пространственного деформирования гофробалок
Authors: МАКЕЕВ Сергей Александрович , СИЛИНА Наталья Геннадьевна , СОКОЛОВСКИЙ Зиновий Наумович
Published: June 2021

Построение адекватной математической модели пространственного изгиба гофробалок в упругой постановке с учетом больших перемещений - актуальная задача. Ее решение даст возможность исследовать общую устойчивость гофробалок, в том числе при нагрузках, превышающих критические. Построена математическая модель прямого стержня, включая гофробалки, в режиме косого изгиба с растяжением-сжатием и кручением. Разработанная модель представлена системой 12 нелинейных дифференциальных уравнений с возможностью исследования напряженно-деформированного состояния балок переменного сечения, загруженных различными поперечными распределенными и сосредоточенными нагрузками, с любыми граничными условиями закрепления. Предлагаемая модель применима для оценки критических нагрузок методом неидеальностей, а также для исследования закритического поведения прямых стержней при потере общей устойчивости при изгибе, в том числе балок с гофрированными стенками. Разработан, реализован и верифицирован алгоритм решения предложенной системы дифференциальных уравнений. С помощью данной математической модели проведено численное исследование поведения экспериментальной гофробалки в режиме поперечного изгиба в плоскости стенки с верификацией нагрузок, соответствующих первой форме потери устойчивости балки из плоскости стенки в ЛИРА-САПР.
Надежность и экологическая безопасность водопроводных и водоотводящих трубопроводов
Authors: ПРИМИН Олег Григорьевич , ГРОМОВ Григорий Николаевич
Published: June 2021

В статье рассматривается надежность и экологическая безопасность водопроводных и водоотводящих трубопроводов централизованных систем водоснабжения и водоотведения. Показано, что нарастающие темпы износа сетей водоснабжения и водоотведения городов и поселений России, ограничение материальных ресурсов на их восстановление обострили в последние годы проблему обеспечения их надежности. Приведены причины низкой надежности трубопроводов. Отмечено, что определяющим критерием экологической безопасности трубопроводов является надежность, один из основных показателей качества любой конструкции (системы). Выполнены статистическая оценка показателей надежности водопроводных и водоотводящих трубопроводов и анализ факторов, формирующих их изменение. На примере системы водоснабжения города Москвы рассчитаны эмпирические зависимости интенсивности отказов водопроводных труб от их диаметров, а также влияния интенсивности и вероятности засоров керамических труб. Предложена стратегия планирования восстановления и обновления трубопроводов и снижения всех видов потерь воды.
Расчетные зависимости для прогнозирования технического состояния железобетонных конструкций
Authors: ГУСЕВ Борис Владимирович , ФАЙВУСОВИЧ Александр Соломонович
Published: June 2021

Построена математическая модель процессов хлоридной и карбонатной коррозии, в которой учтен массоперенос кислотного реагента в капиллярах продольного направления с перетоком в поперечные. В поперечных капиллярах протекает реакция нейтрализации с образованием подвижной границы фазового превращения. Представлена система уравнений, определяющих концентрацию реагентов в свободном и связанном состоянии. Получены зависимости, характеризующие форму и перемещение фронта коррозии, за которым располагается полностью нейтрализованный слой с плоской границей раздела между ними. Приведены зависимости для прогнозирования технического состояния конструкций в условиях карбонатной и хлоридной коррозии. Исходные данные для прогнозирования предусмотрено определять на основе данных о распределении концентраций агрессивного компонента в связанном состоянии и общих данных в эксплуатируемых конструкциях. Предложенная методика определения обобщенных параметров по данным распределения концентраций по глубине слоя эксплуатируемых конструкций обеспечивает повышенную точность прогнозирования.
Методика контрольных испытаний муфтовых соединений арматуры, имитирующих сейсмические нагрузки
Authors: РАХМАНОВ Виктор Алексеевич , САФОНОВ Александр Александрович
Published: June 2021

Приведены результаты исследований муфтовых соединений арматуры, выполненных в институте ВНИИжелезобетон по методике малоцикловых нагружений в соответствии с требованиями государственного стандарта "Соединения арматуры механические для железобетонных конструкций. Методы испытаний". Испытания выполняли на современном оборудовании фирм SCHENCK (Германия) и MTS (США), обеспечивающем соблюдение всех требований стандарта по методике исследований, а также компьютерные замеры и обработку полученных данных. Установлено, что опрессованные муфтовые соединения имеют ряд недостатков, обусловленных их сборкой, контролем за расположением соединенных стержней, усилием обжатия и точностью геометрических размеров муфт. Это ограничивает возможности использования таких соединений для зданий и сооружений, воспринимающих сейсмические нагрузки, без проведения контрольных испытаний на малоцикловую выносливость при переменном растяжении-сжатии с высоким уровнем упругопластического нагружения. Выявлена ошибочность требований по ряду показателей нормативного документа, устанавливающего технические требования к механическим соединениям арматуры для железобетонных конструкций, и обоснована необходимость его доработки.
The use of homeopathic drugs in the complex treatment of periodontal diseases in children with rheumatic diseases
Authors: Skakodub A. A. , Mamеdov Ad. A. , Admakin O. I. , Petukhovа A. I. , Shevlakova A. V.
Published: June 2021

The purpose of our study was to increase the level of treatment of periodontal diseases in children with rheumatic diseases through the use of injections of homeopathic drugs in complex treatment. To do this, they conducted a dental examination of children with rheumatological diseases, determined the degree of damage to periodontal tissues using the indices PMA, GI, CPITN and compared with the control group of children. The relationship between inflammatory processes in in periodontal tissues and rheumatic diseases in children was revealed and the effectiveness of homeopathic drugs in the complex treatment of periodontal tissues was assessed.
Perception of Non-Malay Malaysians Towards the Jawi Script as a National Heritage
Authors: Ramli Ahmad Fahmi
Published: June 2021

The Jawi script is a Malay traditional writing system adapted from the Arabic alphabet which was once used widely during the reign of the British Empire before Romanisation of the Malay writing system took place. It is regarded as a national heritage of Malaysia due to the fact that Bahasa Melayu is the national language of the country. There have been many initiatives taken by the government in preserving the Jawi script including the insertion of Jawi lessons in the Bahasa Melayu subject at the primary school level. However, the new education policy has roused an argument among Malaysians, particularly non-Malays who have been in disagreement towards the new syllabus implemented. The study examined the perceptions and attitudes of non-Malays in Malaysia towards the Jawi script. This descriptive study involved 30 respondents who were approached and invited to participate in the survey. The result portrayed that the participants showed neutral perceptions towards the Jawi script on the basis that it has its own artistic values that should be preserved.
Web-based Digital Agreement System for Freelancers: Case Study in Bangladesh
Authors: MAT ABDUL RAHMAN , AHMED HUMAYRA
Published: June 2021

Nowadays, many people are interested in working as a freelancer because it gives opportunities to people to choose their work according to their convenience. Currently, the people of Bangladesh are using a bidding or direct booking system for buying and selling freelance services. There are very limited opportunities for freelancers to promote their work. Therefore, the purpose of the proposed system is to provide a platform where freelancers can promote their skills and at the same time customers can post job offers and create an agreement with the freelancer. This agreement will create a bridge between the customer and the freelancer. It is hoped that the proposed system will provide a more convenient way for freelancers in Bangladesh to promote their skills and find freelance jobs.
Optimalisasi Investasi Dana Haji Melalui Sukuk dan Deposito Bank Syariah Terhadap Pengembangan Dana Haji Di Indonesia Periode 2016 - 2019
Authors: Safitriawati Tita , Fauziah Ulfah Indar , Widayati Neneng
Published: June 2021

Abstract: Development of Hajj funds in Indonesia for the 2016-2019 period. This research uses a descriptive method by analyzing data taken from secondary data directly to the BPKH website and literature study. The data analysis technique used is data collection, data reduction, data display, verification, and concluding.

The results of this study indicate that the optimization of investment in hajj funds through Sukuk and Islamic bank deposits has increased from year to year so that it can increase financing in organizing Hajj. In 2018, referring to PP. 5 In 2018, BPKH plans to differentiate Hajj fund investments in gold (5%), direct investment (15%), and other investments (10%).

Besides, the proportion of placement of funds in savings/time deposits decreased to 50% and placements in Sukuk to 20%. Then, in 2020, the proportion of placement of funds in savings/time deposits will again decrease to only 30% and transfer this proportion to Sukuk and direct investment.
Analisis Pengaruh Profitabilitas Dan Kebijakan Dividen Terhadap Nilai Perusahaan Dengan Kapitalisasi Pasar Sebagai Variabel Moderasi (Studi Pada Perusahaan yang Tercatat di Indeks JII70 Periode 2017-2019)
Authors: Haris Setiawan Achmad , Nanang Choiruddin Muhammad
Published: June 2021

Abstract: This study aims to find the effect of profitability and dividend policy on firm value with market capitalization as a moderating variable for companies listed on the JII70 Index for the 2017-2019 period. This research is a quantitative research type with a sample population of 104 companies listed in the JII70 Index listed on the Indonesia Stock Exchange in the 2017-2019 period. Furthermore, purposive sampling was carried out to obtain 34 companies that fit the criteria. The results obtained in this study indicate that there is a significant influence between profitability and market capitalization on firm value, only dividend policy has no significant effect on firm value. Meanwhile, the MRA test shows that market capitalization is not able to partially moderate the relationship between profitability and dividend policy on firm value.
Video Advertising: Connection and differences between consumers?
Authors: Ferreira Sónia , Santos Sara , Santo Pedro Espírito
Published: June 2021

The internet search trend has caused that online users are looking for more and more enriched information. The evolution of social media has been huge and users relate to social networks differently than they did before. Currently, there are more than 4 billion active users on social networks and brands are looking to showcase their products and services. Our research found the following factors that influence social media engagement: informativeness, self-connection and advertising stimulation. Through literature review, we propose a conceptual model that has been tested in the PLS-SEM. Data were collected from 237 consumers and our survey found that engagement in social media is explained by the variables identified by our model. Important contributions to brand theory and management will be found in this investigation.
Barragens e seus impactos psicossociais
Authors: Duarte Daniele Almeida , Sbardelotto Denise Kloeckner
Published: June 2021

Esta obra reúne textos de pesquisadores de diversas áreas de conhecimento e atuação. O que há em comum entre eles é o debruçar-se sobre o universo das barragens. De diferentes ângulos revelam as distintas repercussões sobre as comunidades e populações afetadas por estas estruturas. São analisados os efeitos macro e microssociais. Simbólicos e concretos. Individuais e coletivos. A partir de cada uma dessas dimensões, são elaboradas ponderações atentas acerca desse fenômeno, o qual possui complexidade e singularidade capazes de gerar consequências imediatas e a longo prazo.
RETRACTED: Tumor-Derived Extracellular Vesicles Promote Activation of Carcinoma-Associated Fibroblasts and Facilitate Invasion and Metastasis of Ovarian Cancer by Carrying miR-630
Authors: Cui Yulan , Wang Deying , Xie Min
Published: June 2021

Ovarian cancer (OC) is a lethal gynecological malignancy. Extracellular vesicles (EVs) are crucial media in cell-to-cell communication by carrying microRNAs (miRs). The current study aims to investigate the underlying mechanism of miR-630 carried by OC cell-derived EVs in regard to invasion and metastasis of OC cells. miRs related to OC metastasis were searched and screened. The expression patterns of screened miRs in human normal fibroblasts (NFs) and carcinoma-associated fibroblasts (CAFs) were detected using RT-qPCR. miR-630 related to OC metastasis and CAFs activation was analyzed further. The levels of FAP and α-SMA were detected using Western blotting and immunofluorescence. The migration of NFs was measured using Transwell assay. OC cell-derived EVs were isolated and identified. Uptake of EVs by NFs was observed using immunofluorescence staining. The culture supernatant of NFs was collected and used to culture the low metastasis cell line OVCAR8. The migration and invasion of OC cells and epithelial mesenchymal transition (EMT) were measured. Moreover, a xenograft model was established by injecting OVCAR8 cells of different groups into nude mice. Lastly, the effect of EV-pretreated NFs on invasion and metastasis of OC cells was observed in vivo. miR-630 was upregulated in OC cells and CAFs, and further associated with CAF activation and OC metastasis. miR-630 overexpression increased the levels of FAP and α-SMA in NFs, resulting in the transformation of NFs into CAFs. EVs carried miR-630 into NFs and EVs promoted CAF activation. miR-630 targeted KLF6. miR-630 inhibition or KLF6 overexpression attenuated EVs-induced CAF activation. EVs activated the NF-κB pathway via the miR-630/KLF6 axis. The conditioned medium of NFs pretreated with EVs promoted the invasion and metastasis of OVCAR8 cells, while downregulating miR-630 in EVs partially inhibited the promotive effect of NFs. EV-pretreated NFs promoted invasion and metastasis of OC in vivo. In conclusion, EVs carried miR-630 into NFs, thereby facilitating CAF activation and promoting invasion and metastasis of OC by inhibiting KLF6 and activating the NF-κB pathway. Our findings might offer a novel mechanism of invasion and metastasis of OC from the perspective of tumor microenvironment.
Novel Cell Culture Paradigm Prolongs Mouse Corneal Epithelial Cell Proliferative Activity in vitro and in vivo
Authors: An Xiaoya , Wang Guoliang , Jin Mengyi , Zhou Xiaoping , Gao Shubin , Chen Jingyao , Reinach Peter S. , Liu Zuguo , Xue Yuhua , Li Cheng
Published: June 2021

It has been a long-standing challenge to obtain from cell cultures adequate amounts of mouse corneal epithelial cells (mCEC) to perform transplantation surgery. This limitation is attributable to the passage dependent declines in their proliferative activity. We describe here development of a novel 6C medium that contains six different modulators of different signaling pathways, which control proliferative mCEC activity. Its usage shortens the time and effort required to obtain epithelial sheets for hastening healing of an epithelial wound in an experimental animal model. This serum-free 6C medium contains:Y27632, forskolin, SB431542, DAPT, IWP-2, LDN-193189 and also DermaLife K keratinocyte calcium. Their inclusion inhibits rises in four specific markers of epithelial mesenchymal transdifferentiation:ZEB1/2, Snail, β-catenin and α-SMA. This medium is applied in a feeder-free air-lifted system to obtain sufficient populations of epithelial progenitor cells whose procurement is facilitated due to suppression of progenitor epithelial cell transdifferentiation into epithelial-mesenchymal cells. Diminution of this decline in transdifferentiation was confirmed based on the invariance of P63, K14, Pax6, and K12 gene expression levels. This cell culture technique is expected to facilitate ex vivo characterization of mechanisms underlying cell fate determination. Furthermore, its implementation will improve yields of progenitor mouse corneal epithelial cells, which increases the likelihood of using these cells as a source to generate epithelial sheets for performing transplantation surgery to treat limbal stem cell deficiency in a clinical setting. In addition, the novel insight obtainable from such studies is expected to improve the outcomes of corneal regenerative medicine.
Comprehensive Analysis of the Immune Infiltrates and PD-L1 of m6A RNA Methylation Regulators in Hepatocellular Carcinoma
Authors: Xu Yangtao , He Xiaoqin , Deng Junjian , Xiong Lin , Li Yue , Zhang Xiaoyu , Chen Wenliang , Liu Xin , Xu Ximing
Published: June 2021

Recently, N6-methyladenosine (m6A) RNA methylation in eukaryotic mRNA has become increasingly obvious in the pathogenesis and prognosis of cancer. Moreover, tumor microenvironment is involved in the regulation of tumorigenesis. In our research, the clinical data, including 374 tumor and 50 normal patients, were obtained from The Cancer Genome Atlas (TCGA). Then 19 m6A regulators were selected from other studies. Hepatocellular carcinoma (HCC) patients were clustered in cluster1/2, according to the consensus clustering for the m6A RNA regulators. We found that m6A regulators were upregulated in cluster1. The cluster1 was associated with higher programmed death ligand 1 (PD-L1) expression level, higher immunoscore, worse prognosis, and distinct immune cell infiltration compared with cluster2. Five risk signatures were identified, including YTH N6-methyladenosine RNA-binding protein 1, YTHDF2, heterogeneous nuclear ribonucleoprotein C, WT1-associated protein, and methyltransferase-like 3, based on univariate Cox and least absolute shrinkage and selection operator regression analysis. High-risk group and low-risk group HCC patients were selected based on the risk score. Similarly, the high-risk group was extremely associated with higher PD-L1 expression level, higher grade, and worse overall survival (OS). Also, cluster1 was mainly enriched in high-risk group. Receiver operating characteristic (ROC) and a nomogram were used to predict the ability and the probability of 3- and 5-year OS of HCC patients. The time-dependent ROC curve (AUC) reached 0.77, 0.67, and 0.68 at 1, 3, and 5 years in the training dataset. Also, AUC areas of 1, 3, and 5 years were 0.7, 0.63, and 0.55 in the validation dataset. The gene set enrichment analysis showed that MTOR signaling pathway and WNT signaling pathway were correlated with cluster1 and high-risk group. Collectively, the research showed that the m6A regulators were significantly associated with tumor immune microenvironment in HCC. Risk characteristics based on m6A regulators may predict prognosis in patients with HCC and provide a new therapeutic target for improving the efficacy of immunotherapy.
HIV-1 Transactivator of Transcription (Tat) Co-operates With AP-1 Factors to Enhance c-MYC Transcription
Authors: Alves de Souza Rios Leonardo , Mapekula Lungile , Mdletshe Nontlantla , Chetty Dharshnee , Mowla Shaheen
Published: June 2021

HIV-1 infection often leads to the development of co-morbidities including cancer. Burkitt lymphoma (BL) is one of the most over-represented non-Hodgkin lymphoma among HIV-infected individuals, and displays a highly aggressive phenotype in this population group, with comparatively poorer outcomes, despite these patients being on anti-retroviral therapy. Accumulating evidence indicates that the molecular pathogenesis of HIV-associated malignancies is unique, with components of the virus playing an active role in driving oncogenesis, and in order to improve patient prognosis and treatment, a better understanding of disease pathobiology and progression is needed. In this study, we found HIV-1 Tat to be localized within the tumor cells of BL patients, and enhanced expression of oncogenic c-MYC in these cells. Using luciferase reporter assays we show that HIV-1 Tat enhances thec-MYCgene promoter activity and that this is partially mediated via two AP-1 binding elements located at positions -1128 and -1375 bp, as revealed by mutagenesis experiments. We further demonstrate, using pull-down assays, that Tat can exist within a protein complex with the AP-1 factor JunB, and that this complex can bind these AP-1 sites within thec-MYCpromoter, as shown byin vivochromatin immunoprecipitation assays. Therefore, these findings show that in HIV-infected individuals, Tat infiltrates B-cells, where it can enhance the expression of oncogenic factors, which contributes toward the more aggressive disease phenotype observed in these patients.
Influence of Terminal Functionality on the Crystal Packing Behaviour and Cytotoxicity of Aromatic Oligoamides
Authors: Delfosse Pierre , Seaton Colin C. , Male Louise , Lord Rianne M. , Pike Sarah J.
Published: June 2021

The synthesis and characterization of three aromatic oligoamides, constructed from the same pyridyl carboxamide core but incorporating distinct end groups of acetyl (Ac) 1, tert-butyloxycarbonyl (Boc) 2 and amine 3 is reported. Single crystal X-ray diffraction analysis of 1–3 and a dimethylsulfoxide (DMSO) solvate of 2 (2-DMSO), has identified the presence of a range of intra- and intermolecular interactions including N-H⋯N, N-H⋯O=C and N-H⋯O=S(CH3)2 hydrogen-bonding interactions, C-H⋯π interactions and off-set, face-to-face stacking π-π interactions that support the variety of slipped stack, herringbone and cofacial crystal packing arrangements observed in 1–3. Additionally, the cytotoxicity of this series of aromatic oligoamides was assessed against two human ovarian (A2780 and A2780cisR), two human breast (MCF-7 and MDA-MB-231) cancerous cell lines and one non-malignant human epithelial cell line (PNT-2), to investigate the influence of the terminal functionality of these aromatic oligoamides on their biological activity. The chemosensitivity results highlight that modification of the terminal group from Ac to Boc in 1 and 2 leads to a 3-fold increase in antiproliferative activity against the cisplatin-sensitive ovarian carcinoma cell line, A2780. The presence of the amine termini in 3 gave the only member of the series to display activity against the cisplatin-resistance ovarian carcinoma cell line, A2780cisR. Compound 2 is the lead candidate of this series, displaying high selectivity towards A2780 cancer cells when compared to non-malignant PNT-2 cells, with a selectivity index value >4.2. Importantly, this compound is more selective towards A2780 (cf. PNT-2) than the clinical platinum drugs oxaliplatin by > 2.6-fold and carboplatin by > 1.6-fold.
Health Communication and Inter-professional Care in Context of Multimorbidity Management: Assessment of Health Professional Curricular Focus in India
Authors: Pati Sanghamitra , Sinha Rajeshwari , Mahapatra Pranab
Published: June 2021

To meet the long term care demands of chronic diseases as well as multimorbidity, healthcare providers from different disciplines need to work collaboratively in practice. This requires healthcare providers to be appropriately trained on delivery of inter-professional care (IPC) and health communication aspects during formative professional years. In this study, we have looked at the prevailing undergraduate and postgraduate healthcare professional curricula to understand the focus on health communication and on IPC for the delivery of multidisciplinary care for multimorbidity management. We observe that while there are exclusive courses on health communication being delivered at different levels, the focus on IPC is still in stages of infancy. The IPC component is just beginning to be woven into the health professional curricula through elements like competency-based curriculum, rotational posting, inter-departmental engagements. At the same time, the need to put curricular attention on multimorbidity is also highlighted here. There remains wider scope for strengthening learning on health communication and IPC among different disciplines within the curricula in the context of multimorbidity. We expect our findings to provide key inputs to academic planners and policy makers towards the introduction of adequate curricular components for addressing multimorbidity along with necessary prescriptions for health communication and IPC in India.
Using Rhetorical Situations to Examine and Improve Vaccination Communication
Authors: Ihlen Øyvind , Toledano Margalit , Just Sine Nørholm
Published: June 2021

Opinion polls have documented a considerable public skepticism towards a COVID-19 vaccine. Seeking to address the vaccine skepticism challenge this essay surveys the research on vaccine hesitancy and trust building through the lens of therhetorical situationand points towards five broad principles for a content strategy for public health communicators in regards to vaccination: 1) vaccine hesitancy is not irrational per se; 2) messages should be tailored to the various hesitancy drivers; 3) what is perceived as trustworthy is situational and constantly negotiated; 4) in areas of uncertainty where no exact knowledge exists, the character of the speaker becomes more important; and 5) the trustworthiness of the speaker can be strengthened through finding some common ground—such as shared feelings or accepted premises—with the audience. Such common insights are on offer in the literature on rhetoric and persuasion and linked here with the research on vaccine communication and trust focusing specifically on the latter and character.