bluuebunny/crossref_metadata_2025 huggingface dataset:
Teaching Idiomatic Expressions Through Storytelling Based on Narrative Thinking
Authors: Rho Yoon-Ah
Published: September 2024

The purpose of this paper is to observe how efficiently idiomatic expressions are taught through storytelling based on narrative thinking. Storytelling is an enjoyable technique, and it is believed that students can learn cultural and historical knowledge from idiomatic expressions. Therefore, the combination of storytelling and idiomatic expressions can be an effective method for teaching sporadic EFL learners who struggle with consistent English study. Five working adult learners were selected as participants and provided with idiomatic expressions from YouTube Shorts. After 12 weeks, they took four tests: vocabulary, idiomatic expression translation, idiomatic expression memorization, and grammar. Additionally, participants’ responses were collected through a survey. Results showed that all participants performed excellently on the vocabulary test. The translation of idiomatic expressions was successful, with four participants achieving perfect scores and one missing only one item. In the idiomatic expression memorization test, all participants demonstrated good results. In the grammar test, they showed notable proficiency. In response to open-ended questions, all participants agreed that learning English with idiomatic expressions through storytelling was enjoyable. Based on these results, this study suggests that learning idiomatic expressions can enhance the interest and engagement of sporadic learners.
History and Historicism in ‘British’ Cyprus and ‘French’ Tunisia: A Comparative Study of Colonial Architecture Across the Mediterranean
Authors: Coslett Daniel E.
Published: September 2024

British and French colonial administrations exploited various aspects of the histories of Cyprus and Tunisia to justify their occupation of those countries during the late 19th and 20th centuries. There, archaeologists unearthed Greek, Roman, Christian, and medieval artifacts that testified to the Mediterranean’s rich, complex history and the various cultural networks that have bound it together. As the same time, designers created complementary historicist architectures that facilitated self- aggrandizing presentations suggesting that the European colonial presence was both historically precedented and superior. Architecturally, such claims can be seen in many of the government buildings, Christian churches, and antiquities museums built by colonizers in each context. This article presents an account of these colonial-era built environments constructed in Cyprus and Tunisia by Britain and France (1878–1960 and 1881–1956, respectively) through several conceptions of the Mediterranean cultivated by colonizers, including Ancient Greek and Roman, early Christian, and medieval Crusader lenses. It does this through an underutilized comparative thematic method that crosses the boundaries of European empires and is thus an approach with potential for application to other colonial situations. Ultimately, the article invites the development of additional comparative projects that span empires, geographies, and themes, in order to facilitate an understanding of salient colonial-era built environments and global architectural histories that transcend national borders and colonialist rhetoric.
A Comparative Analysis of the Design and Implementation of the Twin Peaks Model of Financial Regulation in South Africa and Australia
Authors: Chitimira Howard , Mavhuru Luck
Published: September 2024

Abstract
In response to the 2007-2009 global financial crisis, South Africa, like most other countries, embarked on a journey of financial regulatory reform. This transformation has seen the country shift away from a silo approach, where various sectoral regulators supervise different financial institutions, towards the Twin Peaks model of financial regulation. The term “Twin Peaks” refers to the separation of regulatory functions between two independent regulators. For instance, one regulatory agency is responsible for the supervision of the safety and soundness of financial institutions, and the other is focussed on the regulation of business conduct. The Twin Peaks model is designed to provide the benefits and efficiencies of an integrated approach while simultaneously addressing inherent conflicts between the objectives of the safety and soundness of the financial system and consumer protection. The Financial Sector Regulation Act provides for the Twin Peaks model in South Africa. This Act positions South Africa as one of the first developing countries to adopt the model. On the other hand, Australia is the pioneer of the model since it implemented it in 1998. Its implementation in Australia, much as in South Africa, involved the separation of regulators for prudential soundness on the one hand and market conduct and consumer protection on the other. In this article, the authors provide a comparative analysis of the design and implementation of the Twin Peaks model in Australia and South Africa. They argue that while there are minor differences between the design and implementation of this model in Australia and South Africa, the model was customised and implemented to align with the specific needs of each country
F13B regulates angiogenesis and tumor progression in hepatocellular carcinoma via the HIF-1α/VEGF pathway
Authors: Jiang Dong , Qi Zhi , Xu Zhi-ying , Li Yi-ran
Published: September 2024

Hepatocellular carcinoma (HCC) is a highly aggressive malignant tumor with a poor prognosis. This research aimed to investigate the role of F13B in HCC and its underlying mechanisms. Through comprehensive bioinformatics analysis of the GSE120123 and The Cancer Genome Atlas (TCGA)-Liver hepatocellular carcinoma (LIHC) datasets, we identified 220 overlapping prognosis-related genes. Eight key genes, including the previously unreported CCDC170 and F13B in HCC, were identified through Least Absolute Shrinkage and Selection Operator (LASSO)-Cox regression analysis. F13B emerged as a significant prognostic factor in HCC, warranting further investigation in subsequent analyses. In vitro experiments showed that F13B expression was notably reduced in HCC cell lines and tissues, particularly in Huh-7 and SMMC-7721 cells. Overexpression of F13B inhibited cell invasion, migration, and proliferation, while its knockdown produced the opposite effect. A lactate dehydrogenase (LDH) activity assay in human umbilical vein endothelial cells (HUVECs) demonstrated that F13B overexpression reduced vascular endothelial growth factor (VEGF)-induced cytotoxicity, whereas knockdown increased it. Further analysis revealed that F13B negatively regulates VEGFA expression, affecting HUVEC proliferation. In HUVECs, F13B overexpression reversed VEGF-induced upregulation of key angiogenesis markers, including phospho-VEGF receptor 2 (p-VEGFR2), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), as well as AKT/mTOR signaling proteins, phospho-Akt (p-AKT), and phospho-mTOR (p-mTOR). Additionally, F13B negatively regulated VEGFA and hypoxia-inducible factor 1 A (HIF1A) under hypoxic conditions, counteracting the hypoxia-induced increase in cell viability. These findings suggest that F13B regulates angiogenesis through the HIF-1α/VEGF pathway and plays a crucial role in HCC progression. Our results highlight the potential of F13B as a therapeutic target in HCC, providing novel insights into the molecular mechanisms of HCC and its prognostic significance.
The Definition of Individual Biological Fitness
Authors: Gustavo Gollo
Published: September 2024

“Fitness” is one of the central concepts in biology. Despite this, the concept is still not clearly defined. Previous attempts at definition refer to what should be called an individual’s “potential fitness,” or, when mathematized, the relative fitness of genetic alleles. In contrast, the present work defines the actual fitness of an individual, exactly what is referred to in the expression “survival of the fittest.” This represents a new conceptualization, a mathematical definition that will extend across the entire set of ideas related to evolution.
Fluorescent Gelatin Degradation Assay to Evaluate EVh Action in TME Cells v1
Authors: Cruz Pachane Bianca , Sobreiro Selistre de Araujo Heloisa
Published: September 2024

The fluorescent gelatin degradation assay is a method to study cell invasion by detecting gelatinase activity in vitro upon epifluorescence microscopy analysis. In this protocol, the method has been applied to evaluate the effect of hypoxic EVs from TNBC cell line MDA-MB-231 in four cellular models for the tumor microenvironment - MDA-MB-231 (tumor cell), HUVEC (endothelial cell), HDFa (dermal fibroblast) and THP-1 (monocyte). Adapted from Pachane et al (2022) (PMID: 36293503).
Towards standardisation of parameter reporting for melt electrowriting v1
Authors: Menke Sönke , Tandon Biranche , Brugger Juergen
Published: September 2024

This protocol aims to help researchers collect all necessary data to make their research in melt electrowriting more reproducible and easier to compare to the data of others.
Tomogram Reconstruction and Gold Fiducial Removal with WarpTools, Etomo, and Fidder v2
Authors: Garrels Connor , Barad Benjamin , Reichow Steve
Published: September 2024

While gold nanoparticle fiducials greatly improve tilt-series alignment in cryo-electron tomography data, they can cause artifacts during later image processing steps. We present a workflow for high-quality fiducial removal using fidder, an open-source python package. This protocol demonstrates how to flexibly incorporate fidder into tomogram reconstruction using Warp and Etomo.
Cell Invasion in Direct Co-Culture v1
Authors: Cruz Pachane Bianca , Sobreiro Selistre de Araujo Heloisa
Published: September 2024

The fluorescent gelatin degradation assay is a method to study cell invasion by detecting gelatinase activity in vitro upon epifluorescence microscopy analysis. In this protocol, the method has been applied to evaluate the effect of hypoxic EVs from TNBC cell line MDA-MB-231 in a direct co-culture assay, using four cellular models for the tumor microenvironment. Hence, MDA-MB-231 (tumor cell), HUVEC (endothelial cell), HDFa (dermal fibroblast), and THP-1 (monocyte) have been seeded in six distinct combinations. Adapted from Pachane et al (2022) (PMID: 36293503).
Total RNA extraction protocol for marine ostracods (bioluminescent and non-bioluminescent ostracods) v1
Authors: Mesrop Lisa
Published: September 2024

Marine ostracods are tiny crustaceans, just 1-2 millimeters in size, with important ecological roles in marine ecosystems. However, extracting RNA from single individuals and specific tissues (upper lip, gut, and compound eye) can be challenging for these tiny marine crustaceans. Here, I optimized an RNA extraction protocol using Agengcourt AMPure XP magnetic beads to extract total RNA from individuals and various tissue types for both bioluminescent and non-bioluminescent ostracods. This protocol is optimized for tissue extraction and works effectively with a single or a few individuals, ensuring high-quality RNA yield from minimal sample input.
A Protocol for Assessing Open Data Practices: Honours Students Can Lead the Way. v2
Authors: Deeb Haya , Zieliński Tomasz , J. Millar Andrew
Published: September 2024

Introduction The culture of scientific research is increasingly recognising the importance of Open Data. Open Data practices involve making research data freely available for others to use, which promotes research integrity, collaboration, and resource efficiency. This protocol aims to assess the openness and FAIRness (Findable, Accessible, Interoperable, and Reusable) of data shared in bioscience research publications. By following this protocol, researchers can systematically evaluate the data-sharing practices in their institutions, thus contributing to a broader culture of open data. This protocol documents the methodology used in the bioscience research field at the University of Edinburgh. The main purpose is to provide a comprehensive and replicable framework that can be adopted by other departments or research domains to evaluate and enhance their data-sharing practices. By sharing this methodology, we invite other institutions and departments to use this protocol to advance the culture of open data in their respective fields. Objective and GoalsObjectiveThe primary objective of this protocol is to evaluate the data-sharing practices in research publications. This involves assessing the completeness, reusability, accessibility, and licensing of data associated with published papers; recording research-related variables such as data types; and publication-related variables such as data availability statements. Goals To provide a structured and consistent methodology for assessing open data practices in bioscience research. To identify trends and challenges in data sharing across different research fields and over time. To promote the adoption of open data practices by highlighting successful examples and areas needing improvement. To encourage Honours students and interns to apply this protocol in their research projects, thus fostering a culture of open data from an early stage in their careers. To encourage other institutions and departments to evaluate their data-sharing practices using this documented methodology, thus fostering a culture of open data across the biosciences.
PANDANGAN TENTANG PRAKTIK BEDAH PLASTIK DALAM ARTIKEL OPINI DI SURAT KABAR KOREA TAHUN 2010–2019
Authors:   Fakultas Ilmu Pengetahuan Budaya, Universitas Indonesia, Adnyana Putu Pramania , Muta’ali Abdul , Suganda Sonya Puspasari
Published: September 2024

This research aims to reveal Korean’s perspectives on plastic surgery practices through a corpus-based text analysis of Korean online newspapers. The research used quantitative and qualitative methods to observe keywords, significant collocates, and semantic preference. The data used were 106 opinion articles about plastic surgery in Chosun Ilbo and Donga Ilbo (2010–2019). Keyword analysis shows that the most frequently used keywords are seonghyeong (189 times) and seonghyeongsusul (116 times). Analysis of significant collocates and semantic preferences revealed that plastic surgery was frequently discussed in relation to body parts, people (collocate yeoseong (women), junggukin (Chinese), hwanja (patient), gwangganggek (tourist)), country (collocate jungguk (China), hangguk (Korea)), intensity (gwadohan (excessive)), and effect (phihae (loss)), and others. Plastic surgery clinics are frequently addressed in terms of location (collocate Gangnam, Seoul), intensity (collocate daehyong (big scale)), and others. Based on the findings of this study, plastic surgery is primarily performed on local women and international patients, particularly Chinese tourists. Plastic surgery is also perceived as having a negative impact, being overdone, and causing numerous difficulties. Plastic surgery performed on foreign patients is considered as beneficial to Korean economic progress, but it should not be performed on Koreans.
KENDHANGAN NARTOSABDAN PEMBENTUK KARAKTERISTIK GENDING SEMARANGAN
Authors:   Pascasarjana ISI Surakarta, Risqia Nanda Indah Nur , Suyoto Suyoto ,   Jurusan Karawitan ISI Surakarta
Published: September 2024

Rambu Solo’ is one of the most expensive traditional funerals in the world. This has created a general impression that Rambu Solo’ must always be lavishly performed, although in reality it can be adjusted to the bereaved family’s financial circumstances. This research seeks to explain how Rambu Solo’ can be motivated by both urgency and prestige using Abraham Maslow’s humanistic psychology theory. This research applied the qualitative method. Data were collected by interviewing a traditional leader named Ambe Tawang with the aid of a local interpreter, Baharuddin Palepong, who lived in Lembang Palesan, Tana Toraja, South Sulawesi. After collection, the data were then analyzed, reduced, presented, and verified. This study found that only few people still perform Rambu Solo’ to gain prestige, while most people in Lembang Palesan perform it
Intraoperative monitoring of visual evoked potentials: experience of 240 operations
Authors: Levin E. A. , Kilchukov M. G. , Glushaeva A. A.
Published: September 2024

Background. Intraoperative monitoring (IOM) of visual evoked potentials (VEPs) is used to inform surgeons about impacts on the visual system in order to prevent iatrogenic visual impairment. The VEP monitoring use become widespread only in the last decade; nowadays, there is no generally accepted methodology for its implementation, and the effectiveness of VEP monitoring and the factors determining it have not been sufficiently studied.Aim. The aim of the study was to investigate the factors influencing the VEP monitoring feasibility and effectiveness.Materials and methods. Data from 240 consecutive neurosurgical operations performed using VEP monitoring were retrospectively reviewed. IOM data (registration parameters, presence and type of VEP changes), patient characteristics (gender and age, tumor type and location, presence of preoperative visual dysfunctions), anesthesia parameters and postoperative changes in vision were studied. Statistical analysis was performed using χ2 and Mann–Whitney tests.Results. VEPs were obtained in 91.3 % of eyes with completely or partially preserved vision. The main factors reducing the chances to record VEPs successfully are preoperative visual disorders and the use of inhalation anesthesia. A personalized approach to the selection of reference electrodes and frequency filtering parameters makes it possible to reduce the number of averagings required for VEP recording and accelerate informing surgeons. With successful monitoring 59.1 % of eyes had no noticeable VEP changes; 5.8 % of eyes had signs of intraoperative improvement; 35.1 % had signs of deterioration. Among the last category, 60.7 % of eyes had full VEPs recovery afterwards. After surgery, new visual disorders were detected in 2.6 % of eyes without signs of intraoperative deterioration, in 6.7 % – with temporary deterioration, and in 19.3 % – with signs of deterioration persisted until IOM is finished. Assessing the sensitivity and specificity of VEP monitoring is hampered by the possibility of complications in the early postoperative period and IOM influence on the course and results of the operation. The proportion of total resections was maximal when VEP monitoring was successful. In the subgroup without preoperative visual impairments, the alarms during monitoring were associated with decrease in proportion of total resections proportion due to increase in proportion of subtotal resections.Conclusion. VEP monitoring with a personalized approach allows effective monitoring of visual functions preservation during neurosurgical operations.
Personality Predictors of the Attitude to the Digitalization of Education among Russian Students
Authors: Kashirskiy D.V. , Sabelnikova N.V.
Published: September 2024

The empirical study explores students’ attitudes towards digital educational technologies and the digitalization of the education system as a whole. The survey, conducted between January and April 2022, shortly after the end of the lockdown, involved students from Russian universities aged from 18 to 38 ( ). The “Attitude towards Digitalization” questionnaire (D.V. Kashirsky, A.S. Ocheretin) and the Big Five Inventory (BFI-2-S, K. Soto, O. John) were used. The results of the survey revealed the extent to which students mastered the skills necessary for studying in a digital environment and whether these skills influenced their academic success. The study also examined the effect of the digitalization of education on the quality of education and identified the most effective learning formats as reported by respondents. Multiple regression analyses identified personality traits (Big Five factors) that underlie students' attitudes towards the digitalization of education. The results can be used to individualize the educational process at universities when implementing various educational technologies.
Cultural Mentoring as Acompañamiento: Rethinking Community Cultural Wealth
Authors: Dyrness Andrea , Bristol Jackquelin , Garzón Daniel
Published: September 2024

In this article, Andrea Dyrness, Jackquelin Bristol, and Daniel Garzón explore how cultural mentoring with elementary students was enacted by undergraduate and graduate students from minoritized backgrounds attending a predominantly white university. They examine how these mentors engaged with a framework of community cultural wealth and borderlands pedagogies of acompañamiento in their interactions with their mentees and in their own and collective reflections. Using testimonies and ethnographic data, the authors illustrate participants’ mutual engagement in the ongoing struggle to make sense of and confront structural injustice and argue that acompañamiento illuminates the reciprocal, transformative relationships between university and elementary students of color in the shared process of developing their critical consciousness.
Keeping It Loose: Promoting Physical Literacy in Schoolyards Through Landscape Design and Movement Provocations
Authors: Sandlos Lisa , Tang Rennie
Published: September 2024

In this essay, Lisa Sandlos and Rennie Tang investigate the potential for movement to play a more significant role in schoolyard design processes to enhance the physical literacy of middle school youth. This research responds to a need for prioritizing physical literacy for historically marginalized youth whose movement needs are often different from what is currently provided by athletics- focused school programming. The study draws on urban design theory, an ecological approach to psychology, movement/ dance studies research theory, and creativity studies to explore landscape design strategies that have the potential to cultivate a more robust culture of physical literacy in schoolyards.
Afrocentricity and Sensory Pedagogy: Teaching and Learning in Prison During COVID-19's Solitary Mass Confinement
Authors: Butticci Annalisa , Long Colie Levar
Published: September 2024

In this Voices: Reflective Accounts of Education essay, Annalisa Butticci and Colie Levar Long reflect on the Afrocentric and sensory pedagogy and positionalities that helped incarcerated students and their teacher create a virtual learning community within one postpandemic prison higher education program. Through an ethnographic study of the online class and autoethnography of their experiences using music as an essential part of the course, they provide valuable insights into teaching and learning during very challenging circumstances and while under emotional duress.
Examining the Schooling Desires of Youth During the COVID-19 Crisis
Authors: Marciano Joanne E. , Peralta Lee Melvin M. , Lee Ji Soo
Published: September 2024

As schools across the US and around the world closed their physical buildings to stop the spread of COVID-19, students, teachers, families, and communities grappled with the shift to online learning. While emerging research examines how educators navigated this shift, little is known about how students experienced schooling as the pandemic unfolded and how their experiences may contribute to emerging calls for reimagining education. In this essay, Joanne E. Marciano, Lee Melvin M. Peralta, and Ji Soo Lee look at how youth navigated online learning in the sixteen months after their schools closed. Using weekly interviews with youth conducted between March 2020 and June 2021, they center the voices of black, Lebanese American, and white students who experienced limited access to economic resources and call attention to the (post)pandemic schooling experiences they needed and desired.
Analysis of the species composition and infection of ticks with pathogens of Lyme disease in the territory of the Republic of Tatarstan for the period 2012–2022
Authors: Karpova Irina A. , Khasanova Gulshat R. , Sadreeva Luciya F. , Tyurin Yurij A. , Shaykhullin Nail N.
Published: September 2024

BACKGROUND: The role of ixodid ticks in the transmission of pathogens of a number of natural focal infections can hardly be overestimated. Analysis of the manifestations of the epizootic process is important for planning preventive and anti-epidemic measures and is an integral component of epidemiological surveillance of natural focal infections.
AIM: To analyze the species composition of ticks and the infection of ticks with borreliosis pathogens in the Republic of Tatarstan for the period 2012–2022.
MATERIALS AND METHODS: An analysis of the species composition of ticks collected by the zoological group of the Center for Hygiene and Epidemiology in the Republic of Tatarstan from environmental objects during the period 2012–2022 was carried out. Testing of the ticks for Borrelia burgdorferi and Borrelia miyamotoi was carried out using the polymerase chain reaction method with hybridization-fluorescent detection. An analysis of statistical observation form No. 2 “Information on infectious and parasitic diseases” (the section “Tick bites”) for the Republic of Tatarstan from 2012 to 2022 was carried out. Statistical processing was performed using descriptive statistics methods in Microsoft Excel.
RESULTS: The total number of people who applied for tick bites in the Republic of Tatarstan in 2012–2022 was 77,703, of which 59,168 (76.2%) were people over 18 years of age. During the study period, 5536 ticks were collected for research on the territory of the Republic of Tatarstan from environmental objects. The species composition of ticks was distributed as follows: Dermacentor reticulatus — 75.4%, Ixodes ricinus — 14.1%, Ixodes persulcatus — 10.5%. Infection of different types of ticks with Borrelia was not the same and was 20.4% for I. persulcatus, 14% for I. ricinus, 4.4% for D. reticulatus. In 4 regions of the republic, from ticks of the species I. ricinus pathogenic genomospecies B. miyamotoi were found (the infestation of this type of tick with B. miyamotoi was 0.4%). Indicators of morbidity of the population with ixodid tick-borne borreliosis and indicators of infection rates for ticks vary in different regions of the republic.
CONCLUSIONS: The dominant species of ixodid ticks in natural epitopes of the Republic of Tatarstan in 2012–2022 were D. reticulatus (75.4% of the total number of collected ticks). For ticks of this species, the lowest level of infection with Borrelia was demonstrated (4.4% of ticks). This may be one of the factors responsible for the low, in comparison with other regions, incidence rates of tick-borreliosis in the Republic of Tatarstan. The identification of ticks of the species I. ricinus infected with B. miyamotoi confirms the need for targeted molecular genetic and serological examination for recurrent fever in patients with non-erythematous forms of febrile illness after an episode of tick bite.
Epileptic activity or eeg similar to epileptic activity. How to recognize? Review
Authors: Guseva Nadezhda L. , Suvorov Nikolay B. , Agapova Elizaveta A. , Sergeev Timofey V. , Filatov Anton Yu. , Shichkina Yulia A. , Kupriyanov Mikhail S.
Published: September 2024

The review examines the recently accumulated clinical and experimental data on the mechanisms of epileptogenesis, and the most appropriate methods for recording an electroencephalogram to detect epileptiform activity. A description of epi-patterns is provided, as well as artifacts – graph elements similar to epi-patterns. All descriptions are supported by appropriate illustrations. In order to identify possible epi-activity, the need for preliminary registration of electroencephalogram with functional tests in the form of rhythmic photostimulation and hyperventilation for a person participating as a subject in studies related to physical and postural loads is emphasized.
Effect of nystatin on invasion of Serratia grimesii and Serratia proteamaculans bacteria into epithelial cells
Authors: Berson Yuliya M.
Published: September 2024

BACKGROUND: Bacteria use various endocytic pathways during entering non-phagocytic cells. The involvement of caveolae/lipid rafts in bacterial invasion has been demonstrated for many bacterial pathogens. However, for bacteria of the genus Serratia, the involvement of membrane microdomains in the process of bacterial internalization has been poorly studied.
AIM: To evaluate the involvement of caveolae/lipid rafts in the invasion of S. grimesii and S. proteamaculans bacteria into non-phagocytic epithelial Caco-2 and M-HeLa cells using nystatin.
MATERIALS AND METHODS: M-HeLa and Caco-2 epithelial cells were incubated with 50 μM nystatin for 1 hour at 37 ºC, after which they were infected with the bacteria S. grimesii strain 30063 and S. proteamaculans strain 94, the multiplicity of infection was 100 bacteria per cell. The number of intracellular bacteria was assessed using gentamicin protection assay. The level of caveolin-1 in cells was visualized using confocal microscopy and Western blotting. The expression of Toll-like receptors genes were measured by real-time RT-PCR.
RESULTS: Treatment of epithelial cells with nystatin reduces the internalization of S. grimesii and S. proteamaculans into M-HeLa cells by 30% and does not affect penetration into Caco-2 cells. At the same time, nystatin does not affect the redistribution / the integrity impairment of lipid rafts and does not lead to the cytoskeleton reorganization of eukaryotic cells. The addition of nystatin increases the level of caveolin-1 in M-HeLa cells (caveolin-1 is not expressed in Caco-2), which leads to a change plasma membrane fluidity. Nystatin promotes the secretion of proinflammatory cytokines interleukin-6 and interleukin-8 in both cell lines. Infection of M-HeLa cells pretreated with nystatin with the studied bacteria leads to an increase in the expression of tlr2 and tlr4 genes, but does not exceed the level of their expression in control samples. Therefore, it is impossible to speak unambiguously about the participation of Toll-like receptors in the invasion of Serratia bacteria.
CONCLUSIONS: The results obtained suggest that the interaction of bacteria with eukaryotic cells induces the expression of caveolin-1, which leads to a change plasma membrane components mobility. This may be due to the fact that β1-integrin is involved in the invasion of the studied bacteria, which should be stabilized at the plasma membrane upon binding of the ligand due to the formation of a cholesterol- and sphingolipid-rich membrane microenvironment.
Main scientific achievements of the academician of the RAS Vladimir Kh. Khavinson: peptides and aging
Authors: Ryzhak Galina A. , Mikhailova Olga N. , Kozina Lyudmila S. , Popovich Irina G. , Arutyunyan Alexander V.
Published: September 2024

The article is dedicated to the memory of the outstanding Russian gerontologist, director of the Saint Petersburg Institute of Bioregulation and Gerontology, academician of the Russian Academy of Sciences, professor Vladimir Kh. Khavinson.
Preliminary Findings: Task Clarity and Credibility in Relational Contracts
Authors: Antic Nemanj , Morjaria Ameet , Talamas Marcos Miguel Ángel
Published: September 2024

We develop and test a relational contracting model where building relationships requires the principal and agent to solve task clarity and credibility problems. We model task clarity as the likelihood of the agent finding a productive action for the principal and demonstrate that it influences the agents propensity to fulfill promises the usual notion of credibility in relational contracts. This is because improving task clarity increases the ease of replacing a relationship after a defection, making defection more tempting. We validate our model using a decade of administrative data from the Ethiopian floriculture industry. Our estimation documents that: i) task clarity problems are economically relevant in the industry and larger for domestic firms, ii) consistent with a unique prediction of our model, domestic firms, due to their lower task clarity and despite a lower discount factor, are less likely to defect on relationships as a response to improvements in the outside option, and iii) the buyer and seller components of task clarity explain differences between foreign and domestic firms in credibility and overall success in relational contracts.
ПІДВИЩЕННЯ ЗНОСОСТІЙКОСТІ ПЛАЗМОВИХ ЕВТЕКТИЧНИХ ПОКРИТТІВ ТЕРМОЦИКЛЮВАННЯМ ЛАЗЕРОМ
Authors: Кіндрачук Мирослав Васильович , Харченко Володимир Володимирович , Тісов Олександр Вікторович , Гуменюк Ігор Анатолійович , Стебелецька Наталія Миронівна , Юрчук Аліна Олександрівна , Гловин Андрій Леонідович
Published: September 2024

У роботі проведено комплексне дослідження структури та властивостей плазмових евтектичних покриттів, після термоциклічної обробки (ТЦО). Показано, що така обробка суттєво підвищує адгезійно – когезійну міцність покриттів. За результатами проведених досліджень встановлено, що стійкість проти спрацювання двошарових покриттів у всьому діапазоні температур вища ніж для одношарових. Це в першу чергу зумовлене підвищенням адгезійних властивостей, зниженням градієнту твердості по глибині покриття, підвищенням термостабільності покриття завдяки бар'єрним властивостям легованого боридного прошарку. Керуючи величиною дисперсних кристалів фаз проникнення і одночасно станом металевої матриці, можна підібрати режими ТЦО, при яких покриття отримують оптимальні триботехнічні властивості.
ДОСЛІДЖЕННЯ МАГНІТНО-ТРИБОЛОГІЧНОГО ВПЛИВУ НА ПАРАМЕТРИ ШОРСТКОСТІ ПОВЕРХНІ
Authors: Свирид Михайло Миколайович , Сидоренко Олександр Юрійович , Смірнов Ігор Володимирович , Хижняк Сергій Васильович
Published: September 2024

Розкрито механізм зміни топографії трибологічного контакту поверхні під дією магнітного поля (МП) 0,3 Тл без змащення. В парі тертя ШХ-15 по контр-тілу діамагнітного класу (склу). Проведено аналіз шорсткості створених трибологічних плівок за умов направленої дії МП в дослідну поверхню. Користуючись критеріем оптимізації параметрів шорсткості (Ra, Rz) та опорною кривою профіля на поверхні тертя було встановлено кореляцію між характеристиками зносостійкості і положенням кривої Abbot-Firestone.
PERFIL DAS INFECÇÕES DE CORRENTE SANGUÍNEA EM UNIDADE DE TERAPIA INTENSIVA PARA COVID-19
Authors: De Albuquerque Feliciano Assucena Tuany , Cavalcanti de Lira Maria da Conceição , Vicente Diniz Maria Eduarda , Da Silva Johnson Kleber , De Araújo Gouveia Viviane , De Araújo Wanderley Flávio , Torres do Couto Milena Tereza
Published: September 2024

Objetivo: Identificar o perfil das Infecções de Corrente Sanguínea (ICS) em pacientes na Unidade de Terapia Intensiva (UTI) de um Hospital de Referência para a COVID-19, na região metropolitana de Recife - Pernambuco, de janeiro a dezembro no ano de 2021.  Método: Trata-se de um estudo transversal, retrospectivo, descritivo, com abordagem quantitativa, realizado através de um banco de dados de um laboratório microbiológico.  Resultados: Foram identificados 24 tipos isolados de microrganismos, onde a maior prevalência foi da espécie Staphylococcus haemolyticus, seguida das espécies Staphylococcus epidermidis, Acinetobacter baumannii, Klebsiella pneumoniae e Staphylococcus hominis. A levofloxacina e a linezolida foram os antimicrobianos mais resistente e sensível, respectivamente, dentre as cepas. Conclusão: Os resultados sobre o perfil microbiológico de infecções de corrente sanguínea em UTI-COVID-19 são de grande importância para traçar estratégias que melhorem a assistência, prevenindo complicações e agravos aos pacientes infectados.
Descritores: SARS-CoV-2; Infecção da corrente sanguínea; Unidade de terapia intensiva.
Kobiety na łamach tygodnika „Odgłosy”
Authors: Olejniczak Elwira
Published: September 2024

Artykuł dotyczy językowych sposobów prezentowania osiągnięć kobiet, które w latach 1968–1977 znalazły się w finale plebiscytu organizowanego przez redakcję łódzkiego tygodnika społeczno-kulturalnego „Odgłosy”. Pomysłodawcom plebiscytu Łodzianin Roku zależało na tym, by docenić wartościowe działania i ludzi, którzy przyczyniali się do rozwoju miasta. W czasie dziesięciu lat trwania konkursu w gronie stu osób pretendujących do tytułu znalazło się dwadzieścia sześć kobiet.
Zagadnieniami wpływającymi na analizę są wybrane elementy teorii językowego obrazu świata, a także konceptualizacja należąca do zasadniczych pojęć z zakresu językoznawstwa kognitywnego.
Materiał badań stanowią sylwetki trzynastu łodzianek, które głosami mieszkańców zdobyły tytuł – Łodzianin Roku. Zgromadzony materiał został przyporządkowany do sześciu kategorii tematycznych, których nazwy są cytatami z omawianych tekstów prasowych: Kobiety, które „otwierają światy nawet nieprzeczuwalne”; „Liczą się minuty i sekundy…” – o ratowaniu życia najmłodszych; „Najrzadsze z operowych ptaków” – łódzkie śpiewaczki; „Jedna jedyna wybrana dziewczyna! Jadzia” – w kręgach teatru, filmu i tańca; „Oto ile może i potrafi jedna słaba kobieta” – kreatorki łódzkiego życia kulturalnego; „Wypełniałam tylko swój obowiązek”.
Zgromadzony materiał pozwolił zaobserwować w jaki sposób opisywano dokonania kobiet ze środowiska naukowego (Anna Rynkowska, Stefania Skwarczyńska, Olga Olgina), które ukazywano jako wizytówki Łodzi, „wychowawczynie pokoleń”, „trwale zrośnięte z uczelniami”. Symbolem nadludzkiej siły i determinacji, osobą dokonującą rzeczy niemożliwych określano na łamach „Odgłosów” lekarza Halinę Krysińską, zaś kobietą – bohaterką była Irena Chojnacka. W gronie wyróżnionych postaci nie zabrakło silnych, zorganizowanych łodzianek mających zdolności przywódcze (Krystyna Kondratiuk – inicjatorka powstawania Muzeum Włókiennictwa, Maria Ryl – współtwórczyni Teatru „Arlekin”, Izabela Nagórko – dbająca o rozwój łódzkich bibliotek, Teresa Skoczylas – kierownik zakładowego ośrodka kulturalnego). Łódzkie śpiewaczki, Teresa Wojtaszek-Kubiak i Teresa May-Czyżowska, były na stronach „Odgłosów” przedstawiane jako „rzadkie operowe ptaki”, promujące Łódź i zachwycające świat talentem. Doceniono także pracę choreograf Jadwigi Hryniewieckiej, założycielki Reprezentacyjnego Zespołu Tańca Związków Zawodowych Włókniarzy im. Harnam oraz zasługi łódzkiej legendy – aktorki Jadwigi Andrzejewskiej.
Łódź i region łódzki w reportażach radiowych Kamili Litman
Authors: Czarnek-Wnuk Paulina , Sygizman Kinga
Published: September 2024

Celem artykułu jest nakreślenie obrazu Łodzi i regionu łódzkiego wyłaniającego się z reportaży radiowych dziennikarki Radia Łódź. Baza materiałowa obejmuje 17 audycji z lat 2012‒2022. W badaniu wykorzystuje się metodę analizy porównawczej uwzględniającej wątki związane z Łodzią i regionem podejmowane w reportażach oraz rozwiązania formalne służące portretowaniu ziemi łódzkiej. W analizowanych audycjach problematyka ta prezentowana jest z perspektywy osób, wydarzeń i miejsc związanych z miastem bądź regionem zarówno w ujęciu współczesnym, jak i historycznym. Szczególnie wyraźnie wyłania się z nich m.in. problematyka żydowska, ale także wizerunek miasta (i regionu), w którym niejednokrotnie rozgrywały się wydarzenia przełomowe dla całego kraju. Dramaturgia reportaży o ziemi łódzkiej budowana jest w oparciu o opozycje takie, jak pamięć i zapomnienie, przeszłość i teraźniejszość czy sceny – audialne obrazy o silnym ładunku emocjonalnym, a dźwiękowe oblicze miasta współtworzą głosy jego mieszkańców bądź osób z nim związanych, licznie reprezentowane archiwalia i muzyka.
„Mam poczucie humoru, więc żyję”. Stefan Szuman i jego szkic psychologiczny „O dowcipie i humorze”
Authors: Kosno Sara , Przeniosło Marek
Published: September 2024

W poniższym artykule szczegółowej analizie poddane zostały takie zjawiska jak: Wielki Humor, Wielki Dowcip, radość, śmiech, ironia, żart oraz inne towarzyszące im pojęcia omówione przez Stefana Szumana w szkicu psychologicznym O dowcipie i humorze. Rozważania uczonego zaprezentowano na szerszym tle jego barwnej biografii. Z uwagi na głębię i wielowątkowość opisywanego dzieła, treści w nim zawarte rozpatrywać można na różnych płaszczyznach, interpretacja zaprezentowana przez autorów jest zatem jednym z wielu jego możliwych odczytań.
Satyryczny obraz polityki mocarstw europejskich w obliczu kryzysu bułgarskiego (1885–1886) w krakowskim „Diable”
Authors: Chrobak Waldemar
Published: September 2024

Kryzys bułgarski (1885–1886) uwidocznił wzrost partykularnych interesów mocarstw europejskich i stanowił naruszenie postanowień kongresu berlińskiego (1878) w kwestii układu sił w rejonie Bałkanów. Wieloznaczna postawa mocarstw wobec dynamicznych wydarzeń mających miejsce od rewolucji w Rumelii Wschodniej w kwietniu 1885 r. do krótkiej wojny serbsko–bułgarskiej (listopad 1885) i zawarcia pokoju tophaneńskiego (kwiecień 1886) była szeroko komentowana w prasie polskiej tego okresu. Tematykę tę podjął również „Diabeł”, ilustrowane pismo satyryczne ukazujące się od 1869 r. w Krakowie. Pojawiały się w nim teksty i ilustracje szydzące z cynicznej polityki europejskich mocarstw wobec narodów Półwyspu Bałkańskiego.
Rosjanie, Białorusini i Polacy kresowi w anegdocie historycznej, czyli z czego się śmiano ponad 100 lat temu
Authors: Jurkowski Roman
Published: September 2024

Artykuł przedstawia kilkanaście anegdot z końca XIX i początku XX w. powstałych na Ziemiach Zabranych I Rzeczypospolitej. Mówią one o Rosjanach, Białorusinach i Polakach. Oprócz nieodzownej w każdej anegdocie dozy humoru i dowcipu, różnią się one od siebie stosunkiem do narodu, którego dotyczą. W anegdotach odnoszących się do Rosjan, widać krytykę, ostrzejszą satyrę, nawet złośliwość – byli to przecież zaborcy. Białorusini byli od dawna częścią kresowego społeczeństwa, są więc traktowani z wyrozumiałością należną najmłodszemu członkowi rodziny. A Polacy, byli różni. Od dziwaków poprzez patriotów do żartownisiów. Prezentowane anegdoty są elementem historii Ziem Zabranych i narodów tam mieszkających.
Stygmatyzacja poprzez wyśmianie osób w wieku starczym i osób samotnych w XIX-wiecznej społeczności chłopskiej
Authors: Gapiński Bartłomiej
Published: September 2024

Artykuł lokuje się na pograniczu refleksji historycznej i etnologicznej. Dotyczy ona stygmatyzacji osób starszych i samotnych (bezżennych oraz niezamężnych) w XIX-wiecznej społeczności chłopskiej. Autor skoncentrował się na wybranych aspektach stygmatyzacji: relacji stary małżonek – młoda żona, obśmiewaniem takiego związku, przywołaniem humorystycznego balu dziadowskiego, poniżaniem osób bezżennych i niezamężnych na co dzień. Wreszcie autor skupił się na obrzędach deprecjonujących samotnych, szczególnie przywołując „kłodę popielcową” i „podkoziołka”. Wnioski do jakich doszedł pozwalają doszukać się osobliwości odpowiadających podziałowi Polski na zabory. Tradycja notarialna (przy przekazywaniu włości) i metaforyczny charakter obrzędów warunkowały starość i samotność w zaborze pruskim. Zabór rosyjski reprezentował wersję kultury, gdzie rozwinęła się również tradycja umów notarialnych, ale obrzędy były związane jeszcze z dokuczliwą, cielesną stygmatyzacją. Najgorzej wyglądała za to sytuacja w Galicji: nie było tradycji notarialnej w przypadku dziedziczenia włości a tylko prawo zwyczajowe, natomiast obrzędy i praktyki życia codziennego cechowała metonimiczność, wiązały się z realną przemocą.
„…by Bachusa uczcić należycie…” Tragiczna śmierć marszałka szlachty guberni mińskiej Leona Osztorpa (1851) w satyrycznej refleksji Ignacego Legatowicza
Authors: Snapkouski Yury
Published: September 2024

Artykuł opowiada o historii postrzegania postaci jednego z najbardziej wybitnych liderów szlachty litewsko-białoruskiego kraju z XIX w. – Leona Osztorpa (1786–1851). Był on właścicielem ziemskim dużych majątków, który przez 24 lata (1823–1847) nieodmiennie zajmował stanowisko gubernialnego marszałka szłachty w Mińsku Litewskim. Jego nagła śmierć w wyniku wypadku, w przeddzień Wielkanocy, zszokowała społeczność i zyskała oddźwięk w twórczości mińskiego satyryka, mistrza epigramatów, Ignacego Legatowicza (1796–1867).
Legatowicz napisał kilka epigramatów na temat śmierci Osztorpa, mających cechy czarnego humoru. W nich zauważalne jest odnotowanie z pewną głębokością psychologiczną tendencji do zmian w społeczeństwie przed końcem epoki pańszczyzny. Rozpowszechnione w formie ustnej i pisemnej epigramaty Legatowicza zyskały szeroką popularność. W pierwszej połowie XX w. korzystał z nich polski historyk, profesor Uniwersytetu Wileńskiego, Janusz Iwaszkiewicz (1879–1944), wydawca pierwszej części wspomnień wybitnego działacza Edwarda Woyniłłowicza (syna chrzestnego Leona Osztorpa). Iwaszkiewicz lokalizował te epigramaty w kontekście dyskursu antyimperialnego (antyrosyjskiego).
Epigramaty Legatowicza, opatrzone negatywnymi komentarzami profesora Iwaszkiewicza wobec Osztorpa, zostały w połowie lat trzydziestych XX w. przedmiotem ostrej zaocznej kontrowersji z nim ze strony sędziwej Michaliny Horwattowej (młodszej siostry Edwarda Woyniłłowicza), która była drugą żoną zięcia Leona Osztorpa – Ottona Horwatta. Michalina Ηorwattowa, będąc nosicielką ustnej historii, ale, oczywiście źle rozumiejąc istotę satyry, przedstawiła własną, stronniczą opinię o Leonie Osztorpie.
O życiu z humorem, o żarcie poważnie – „Trzy po trzy” Aleksandra Fredry w kontekście twórczości oraz życiorysu autora
Authors: Rozental Przemysław
Published: September 2024

O osobie Aleksandra Fredry można mówić wiele. Jest to postać bardzo istotna dla polskiej kultury i sztuki. Powszechnie znany jest on jako postać wesoła – zważywszy na dorobek literacki tego twórcy z zakresu komedii. Znane są również żarty Aleksandra Fredry. Pojawia się jednak pytanie, czy żartował on dla samego żartu? Celem artykułu jest zaprezentowanie problematyki żartu w XIX w. przez pryzmat pamiętnika Aleksandra Fredry Trzy po trzy. Mimo że sam pamiętnik jest przepełniony żartem, to przedstawia on trudne przeżycia autora, jego załamane nadzieje związane z wojnami napoleońskimi oraz wiele innych wydarzeń, które w odczuciu autora wywarły na nim potężne piętno.
Economics and Constraints of Organic Turmeric at Kakching District of Manipur
Authors: Khodang Cenmichon , Sharma Amod
Published: September 2024

Background: As the locale of the present study has high potential for production of organic turmeric, so to take the relevant measures for best exploit the resources and to create more income and employment to the rural people. Methods: The present study is based on 200 turmeric growers drawn by adopting a multistage purposive stratified simple random sampling technique from Kakching district; based on the primary data, collected through personal interview method with the help of pre-tested and well structured questionnaire exclusively designed pertaining for the agricultural year 2020-2022. Result: The majority (93.00 per cent) of the respondents belonged to semi-medium land holding with an area of 2.01 to 3.00 ha, total gross return was highest (₹ 1,61,768.44/-) for medium farm size group and benefit-cost ratio was highest (2.64 : 1) for small farm size group. The major production constraint was lack of proper inputs, lack of training, lack of irrigation facility, lack of quality planting material etc.