bluuebunny/crossref_metadata_2025 huggingface dataset:
Validating an Entrepreneurship-Based Invention Education Instruction Model as Evaluated by Field Experts
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lim Yeong-dae
Published: April 2023

Objectives This study aimed at developing and validating an entrepreneurship-based invention education instruction model and was conducted on field experts teaching entrepreneurship, invention, intellectual property, and startup incorporation.
Methods Through a literature review on domestic and international entrepreneurship, startup incorporation, invention, and intellectual property, the researcher developed an entrepreneurship-based invention education instruction model and conducted a survey using the Delphi method a total of four times with field experts (16 people). After reviewing the results of each survey round, Delphi reviewers/advisors (10 people) and teaching model reviewers/advisors (10 people) provided advice on the model, and subsequently revised, made necessary corrections, and validated it.
Results By applying the Delphi method, this study revealed the following results. First, through a literature review on entrepreneurship, invention, intellectual property, and startup incorporation, components of each of the domains were identified. Based on this, the entrepreneurship-based invention education instruction model (draft) and survey instruments for the first round of the Delphi survey were developed. Second, the second, third, and fourth rounds of a Delphi survey were conducted on field experts (16 people). Results showed that the content validity of the instruction model was 1.00, the degree of consensus was .80 or more, and the degree of convergence was .50 or less. The Content validity of the instructional stages was 1.00, the degree of consensus was .80 or more, and the degree of convergence was .50 or less. In addition, as for the detailed processes, the Content validity was .88 or more, the degree of consensus was .80 or more, and the degree of convergence was .50 or less, while in the case of components, the Content validity was .88 or more, the degree of consensus was .86 or more, and the degree of convergence was .35 or less. As such, field experts validated the results of the four rounds of the Delphi survey and the content validity thereof, arriving at the final entrepreneurship-based invention education instruction model.
Conclusions The instruction model developed in this study is expected to contribute toward nurturing creative talents and fostering a spirit of convergence to promote sustainable development. It is hoped the model will enhance entrepreneurial invention education in the on-going pursuit of realizing new values for the future.
Early Predictors of Delinquency in Middle School Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lim Euijin
Published: April 2023

Objectives The purpose of this study is to classify middle school students accoring to the change of their delinquency measures and to find predictors of delinquency among variables in their 6th grade.
Methods Using Gyeonggi Education Panel Study(GEPS) data for the elementary students panel from 3th year(6th grade in elementary school) to 6th year(3rd grade in middle school), latent growth mixture modeling was applied to classfy middle school students' pattern of delinquency changes, and multinomial logistic regression was conducted to find predictor variables.
Results With latent growth mixture analyses, three latent classes were identified: ‘decreasing from high level’, ‘increasing from low level’, and ‘low-level’. The probability of class membership was significantly predicted by gender, physical self-concept, academic achievement, parental attachment, parental monitoring, and peer relationship.
Conclusions It was suggested to develop a policy-based support system to affect variables in elementary school that predicts students' delinquency in middle school and that teachers in elementary schools can detect easily. Specifically, an early intervention for students with low academic achievement was suggested as an effective approach to prevent delinquency.
Exploring Classification of Latent Groups and Influencing Factors based on Subjective Happiness and Changes in Economic Conditions of Single Parents Before and After COVID-19: Focused on Adolescents’ Changes
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Choi Hyosik , Yeon Eun Mo
Published: April 2023

Objectives The purpose of this study is to identify the latent groups according to changes in subjective happiness and economic conditions of single parents compared to before COVID-19 and to explore variables affecting the identified potential groups. Furthermore, the study confirmed how groups of adolescent has changed compared to before COVID-19.
Methods Using the Living Status of Korean Single-Parent Families Survey in 2021, this study analyzed 2,420 single parents through Latent Profile Analysis. In specific, R3STEP were used to determine whether single parent's gender, age, education, type of government support, and duration were affected by the potential group classification, and BCH were used to determine whether there was a difference in children's changes compared to before COVID-19.
Results First, the latent groups based on subjective happiness and economic conditions compared to before COVID-19 perceived by single parents were identified as seven groups. Second, educational background of single parents, the type of government support, the period of becoming a single parent, and their age had an effect on the classification of latent groups. Third, it was confirmed that the degree of positive change of children was different for each group.
Conclusions This study suggests that children from single parents family can have more positive changes in school life when subjective happiness and economic conditions of their single parents improve compared to before COVID-19.
Ethosomes: A Vesicular Carrier as a Novel Tool for Transdermal Drug Delivery System
Authors: Devaki Jorapur , Pavuluri Satish , Suma Naduvinamani
Published: April 2023

In recent years, nanotechnology has a new era of drug delivery for many drug systems. Transdermal drug delivery is one of the few systems that have recently become a major focal point of research. When compared to traditional drug delivery systems, the Transdermal Drug Delivery System (TDDS) has various advantages. Due to the barrier properties of the Stratum Corneum, TDDS has had limited market success. The introduction of ethosomes, which are soft, malleable vesicular carriers containing ethanol and are tailored for enhanced delivery of active agents, has opened up a new area of vesicular research for transdermal drug delivery. According to various reports, ethosomes have a promising future in improving the efficacy of transdermal delivery of various agents. Ethosomes are also useful for the non-invasive delivery of small, medium and large drug molecules. Ethosome preparation is simple, requires no complicated equipment, and can thus be scaled up to industrial levels. The review emphasises introduction to ethosomes, their composition and preparation methods, evaluation, and their efficiency in penetrating the skin and the use of ethosomes in transdermal medication delivery as being more effective than liposomes or hydroalcoholic solution in terms of quantity and depth.

Keywords: Ethosomes, Novel carriers, Transdermal Drug Delivery System
Herbal Drug Standardization: A Systemic Review
Authors: Lamichhane Suman , Sahariah Bhargab Jyoti , Das Bhaswati , Khatiwara Deepika , Sola Piyong , Adhikari Rudra Prasad , Gogoi Bitu , Alam Tahid
Published: April 2023

The demand for herbal medicinal products and materials is rising, and maintaining their quality is therefore becoming increasingly important. Numerous physical, chemical, and geographical factors that affect these materials' quality also affect the quality of the herbals. In addition, the quality of herbal materials is becoming increasingly a concern due to adulteration. The quality characteristics of the herbal material the herbal pharmaceuticals are assessed using a variety of chemical and phytochemical tests, analytical techniques, and hyphenated analytical techniques. Formulations made from herbs are now widely accepted as effective treatments for many ailments. the creation of reliable analytical techniques, such as quantitative assessments of marker/bioactive chemicals and other techniques, that can accurately profile the phytochemical makeup. For the manufacture and manufacturing of herbal medications, standardisation is a crucial step in establishing a uniform biological activity, consistent chemical profile, or even just a quality assurance programme. It is crucial to follow WHO-specific recommendations for evaluating the quality, safety, and efficacy of herbal medicines as a condition for worldwide harmonisation. An overview of the numerous methods used for the extraction, characterisation, and standardisation of herbal nanomedicines is presented.

Keywords: herbal drugs, standardization, herbal formulation, quality control
Morphometric and molecular sequencing evidence for the identification of Artemia franciscana (Kellogg, 1906) in Southern India
Authors: Biju Y. , Krishnakumar S. , Krishnaveni M.
Published: April 2023

A native of North America, the brine shrimp Artemia franciscana is now a very invasive foreign species that has already been imported to most of the world. Before the introduction of A. franciscana, Asia was home to a wide range of bisexual Artemia species, which is no longer the current case. The collected Artemia samples from salt pans in south India were subjected to exact species identification and determination of phylogeographic origin through morphometric and molecular phylogenetic analysis. The Artemia species was validated with the observation of spiny subspherical frontal knob and distinctive lateral triangular ovisac lobes with projections on its body. The phylogenetic analysis of these Artemia species from two sampling localities was carried out after nucleic acid sequencing. After DNA barcoding of the cytochrome oxidase COI gene, the samples were identified as belonging to A. franciscana.
Study on photoperiodic modulation of the female fertility of Drosophila biarmipes
Authors: Shamim Ahmed Malik , Sayed Zarin Sana
Published: April 2023

Various attributes of light, including the intensity, spectral composition and duration of the photophase, have been documented to have remarkable influence on all aspects of behaviour and physiology of eukaryotic experimental models. This hypothesis was investigated in the present study wherein the effects of photoperiod varying from 6 to 18 h of 24‑h light-dark (LD) cycles was examined on the lifetime fertility (i.e., the viable F1 progeny) of females of the Indian fruit fly, Drosophila biarmipes. The flies were subjected to six types of 24‑h LD cycles (light at 150 lux and dark at 0 lux in all LD cycles) in which the photoperiod varied from extremely short (6 h) to extremely long (18 h) duration. The female fertility was the highest in photoperiods of 10, 12 and 14 h, moderate in 8 and 16 h and the lowest in 6 and 18 h. These results indicate that the performance of the circadian system is at its optimum when it is maintained in zeitgeber cycles wherein the photoperiod is close to that of the natural day of the tropical or sub-tropical region from where the given species or strain originated. This study has great implication in predicting the insect abundance at a particular season of the year when the photoperiod is conducible for optimum reproduction. Such premonition should help the local administrative bodies to take appropriate control measures against the given insect pest and vector insects.
New opportunities and advantages of local coordinate systems created on the basis of SСS-2011
Authors: Obidenko V.I.
Published: April 2023

The new possibilities of local coordinate systems (LCS) created in accordance with their establishment procedure, approved in the Order of Rosreestr dated October 20, 2020 No. p/0387, are shown
Problems of Formation of the Investment Climate in the Republic of Dagestan
Authors: Kugai A. I. , Jamalov M. Sh.
Published: April 2023

Aim. Formulate proposals to improve the state policy of entrepreneurship development and investment climate in the Republic of Dagestan.

Tasks. To study the current state of the investment climate and entrepreneurial activity in the Republic of Dagestan. Consider international experience of interaction between business and public authorities. Determine the main direction in the activities of state and municipal authorities, civil society institutions and the business community of the Republic of Dagestan to create a favorable investment climate in the republic.

Methods. The work uses the methods of social constructivism, institutional, structural-functional and comparative analysis, statistical, as well as formal-logical research methods.

Results. According to the data obtained, the investment sector of the region’s economy needs some improvement. There is a negative dynamics of investments in the fixed capital of the republic, as well as a decrease in the volume of investments per capita in recent years. Data for 20 19–2021 show an increase in the volume of public investment, while the volume of private investment in the fixed capital of the republic is significantly decreasing.

Conclusions. The authors suggest that the authorities authorized in the field of entrepreneurship and investment focus on the information technology direction of investment activity development. It is recommended to improve and actively promote the recently created investment map of the Republic of Dagestan, to ensure the creation of mechanisms for updating it and filling it with new content, which will significantly modernize investment activities and bring it to a qualitatively new level. The largest capital in the stock market is made during periods of recession, thanks to the investment and navigation map. It’s just that people don’t notice it in a crisis.
About BRICS Investment Arbitration
Authors: Skvortsov O. Yu.
Published: April 2023

The article discusses the issue of creating investment arbitration in the BRICS member states. The prerequisites for the creation of this institution are the problems of “classical” investment arbitration, which, in turn, are predetermined by the crisis of globalism as an idea of the world order.

Aim. The purpose of this work is to study the prerequisites and the possibility of creating investment arbitration in the BRICS countries.

Tasks. Within the framework of achieving this goal, the following tasks were solved: analysis of the crisis of the idea of globalism and, as a consequence, the crisis of “classical” investment arbitration; analysis of the regionalization of legal institutions in general and investment arbitration, in particular; analysis of the conditions for the creation of investment arbitration in the BRICS member states.

Methods. The methodology of solving the formulated tasks is based on the identification of those patterns that are characteristic of various periods of the existence of world political, economic and legal relations.

Results. The prerequisites for the creation of BRICS investment arbitration are the problems of “classical” investment arbitration. The author concludes that this crisis entails a tendency to regionalize both communities of states and legal institutions that ensure the functioning of these unions. Hence, there is a need for the formation of regional arbitrations. Since the BRICS community has set as its goal the formation of a coordinated financial, trade and investment policy, it also required the appropriate jurisdictional support of these processes. In addition to the creation of other institutions, the economic needs of the BRICS require the creation of investment arbitration, which should become a mechanism for resolving investment disputes arising between various economic entities.

Conclusions. It is concluded that when creating investment arbitration, it is necessary to abandon the ideology of protecting exclusively the rights of the investor, which has become the dominant idea in matters of economic law and order. In particular, it is necessary to take into account the interests of public entities — recipients of investments. These interests lie in the plane of protecting human rights, public needs, and environmental problems. In addition, it is necessary to abandon the exclusive use of the Anglo-Saxon legal technique, which is imposed within the framework of the existing investment arbitration. In the end, the conclusion is made about the relevance of the creation of the BRICS investment arbitration, that this institution will contribute to the strengt hening and development of ties betw een the states participating in this association.
Experiencia del componente práctico del curso de proyecto de diseño I
Authors: Romero Cuellar Javier Augusto , Pérez Cardona Carmen Adriana
Published: April 2023

The training of industrial designers based on the virtual and distance modality creates a synergy that allows us to chart a new course in education, this is part of the transformation and social mobility of millions of people, this modality is important within our educational process, managing to reach many places where training cannot be accessed and especially in industrial design, being able to bring design closer to many people and contexts is an important challenge that the program has outlined, for this strategies have been implemented which have allowed different students from the territory have access to training.

 

This article exposes some of the results of the exercise of carrying out the development of the practical component of the Design Project I course in the virtual modality.
Ecosistemas digitales en las redes globales de valor: una aproximación desde el análisis de decisiones multicriterio
Authors: Figueroa Peinado Woody , Vásquez Bernal Oscar Alejandro , Pinzón Hoyos Benjamin , Diaz Pulido José Martín , Gómez Méndez José Daniel
Published: April 2023

This paper shows a progress result of the ongoing research on the application of the multi-criteria decision-making Methodology (MCDM) and the Analytical Hierarchy Process (AHP) that allows for defining the most appropriate model in the measurement of the degree of maturity of global value chains, based on the methodological phases for decision making,  through the analysis of existing measurement systems recognized worldwide, that allow selecting the alternatives and their attributes for comparison. In this phase of the research, the incidence of industry 4.0 in the processes of integration of supply chains for the conformation of digital ecosystems is highlighted, its incidence in the adaptive configurations of value chains, and the contribution of technology in the maturity of the same.
Current state and prospects of artificial intelligence in allergy
Authors: Breugel Merlijn van , Fehrmann Rudolf S. N. , Bügel Marnix , Rezwan Faisal I. , Holloway John , Nawijn Martijn , Fontanella Sara , Custovic A , Koppelman Gerard
Published: April 2023

The field of medicine is witnessing an exponential growth of interest in
Artificial Intelligence (AI), which enables new research questions and
the analysis of larger and new types of data. Nevertheless, applications
that go beyond proof of concepts and deliver clinical value remain rare,
especially in the field of allergy and immunology. This narrative review
provides a fundamental understanding of the core concepts of AI and
critically discusses its limitations and open challenges, such as data
availability and bias, along with potential directions to surmount them.
We provide a conceptual framework to structure AI applications within
this field and discuss forefront case examples. Most of these
applications of AI and machine learning in allergy concern supervised
learning and unsupervised clustering, with a strong emphasis on
diagnosis and subtyping. A perspective is shared on guidelines for good
AI practice to guide readers in applying it effectively and safely,
along with prospects of field advancement and initiatives to increase
clinical impact. We anticipate that AI can further deepen our knowledge
of disease mechanisms and contribute to precision medicine in allergy.
Novel isoforms of adhesion G protein coupled receptor B1 (ADGRB1/BAI1) generated from an alternative promoter in intron 17
Authors: Parag Rashed Rezwan , Yamamoto Takahiro , Saito Kiyotaka , Meir Erwin Van
Published: April 2023

Brain-specific angiogenesis inhibitor 1 (BAI1) belongs to the adhesion
G-protein-coupled receptors, which exhibit large multi-domain
extracellular N-termini that mediate cell-cell and cell-matrix
interactions. To explore the existence of BAI1 isoforms, we queried
genomic datasets for markers of active chromatin and new transcript
variants in the ADGRB1 gene. Two major types of mRNAs were identified in
human and mouse brain, those with a start codon in exon 2 encoding a
full-length protein of a predicted size of 173.5 kDa and shorter
transcripts starting from alternative exons at the intron 17/exon 18
boundary with new or exon 19 start codons, predicting shorter isoforms
of 76.9 and 70.8 kDa, respectively. Immunoblots on wild-type and Adgrb1
exon 2-deleted mice, reverse transcription PCR and promoter-luciferase
reporters confirmed that the shorter isoforms originate from an
alternative promoter in intron 17. The shorter BAI1 isoforms lack most
of the N-terminus and are very close in structure to the truncated BAI1
isoform generated through GPS processing from the full-length receptor,
except that the latter exhibits a 19 amino acid extracellular stalk that
can serve as a receptor agonist. Further studies are warranted to
compare the functions of these isoforms and examine the distinct roles
they play in different tissues and cell types.
Exploring Modal Salient Beliefs Underlying Use of Shared Shaving Tools in Low-Publicity Contexts
Authors: Kwitonda Jean Claude
Published: April 2023

Media and health psychology have been complementary in increasing publicity or exposure to health information for the purpose of influencing behavioral modifications. To be relevant, health psychology constructs necessitate formative research to elicit and identify salient beliefs from the perspective of the population of interest. This practice generates theoretically sound and culturally appropriate content especially when the research being conducted is international in scope. This study reports results of an elicitation study that explored modal salient beliefs underlying information, motivation and behavioral skills for negotiating hygiene and haircare in low-income and low-publicity contexts. Results indicate that respondents rely on informational heuristics, which compound their low motivation and efficacy in the various hair care negotiations they have to navigate.
Factual or Perceived? : Comparing Two Dimensions of Scientific Knowledge in the U.S. and South Korea
Authors: Kim Hwalbin , Mckeever Robert , Chang Jeongheon Jc , Ha Ju Yong
Published: April 2023

This study examines predictors of two key dimensions of scientific knowledge: perceived and factual knowledge about genetically modified organisms (GMO) and nuclear energy in the U.S. and South Korea. We also explore how media use and elaborative processing affect two dimensions of scientific knowledge. The findings show that perceived and factual scientific knowledge are conceptually unique across two countries’ samples and not significantly correlated. Most of indicators were not associated with factual knowledge, and attention in newspapers and on the Internet and elaborative processing were related to perceived knowledge. Findings also suggest that the patterns of relationships between scientific knowledge and indicators were not much different between the U.S. and South Korea. We conclude that science researchers, practitioners, and educators associated with public policy of nuclear and GMO technology should measure and treat two dimensions of scientific knowledge independently in research designs, public policy, and science education.
Testing Smokers’ Media and Community Resource Awareness for Tobacco Cessation
Authors: Shin YoungJu , Johnson Nicole L.
Published: April 2023

Tobacco smoking is one of the deadliest behaviors anyone could engage in. Alarmingly, the prevalence of Indiana adult smokers outnumbers the average percentage of national smokers in the United States. In efforts for smoking prevention, State of Indiana has promoted recourses that are available to help quit smoking via media campaigns as well as community based interventions. As part of Indiana Adult Tobacco Study, telephone survey data (N = 376) were collected to investigate Indiana adults’ resource awareness and their smoking behaviors. As a result of logistic regressions and simple linear regressions, findings revealed that Indiana adults’ awareness of telephone quitline services was significantly related to intention to quit smoking, but it was not significantly associated with the past 30-day tobacco use. Indiana adults’ awareness of local programs was not significantly related to intention to quit smoking, but it was significantly associated with the past 30-day tobacco use. Research implications and future directions are discussed.
"Pretend Crazy": comments surrounding romanticizing mental illness on YouTube
Authors: Ng Janelle Shaina , Tandoc Edson C.
Published: April 2023

Discerning whether one has mental illness is not an uncommon conundrum even if it is rarely discussed. Mental illness is highly stigmatised and discernment often happens privately using materials from online sources. Hence, narratives presented in the online space can heavily influence how audiences interpret their mental health. U﻿﻿nhelpful descriptions can be misleading and cause further distress to vulnerable audiences or cause further stigmatisation against the mentally ill. Using an online comment scraper, we extracted the comments section of two popular videos that discuss the issue of romanticizing mental illness and how some people might be ‘faking’ it. Then, using thematic analysis, the comments were organised into themes in reaction to specific video content and discussed. The following surfaced as strong points of discussion in the commentary: vagueness of discerning what is a mental illness experience, trivialization of emotional distress, and what descriptive terms are appropriate and congruent for describing mental illness. Finally, some opportunities for future endeavours to address support for, education, and discernment of mental illness are highlighted.
Curiosity Fulfilling Searches for Sexual Content: Lebanese Adolescents Gratifications from the Internet as a Sex Education Tool
Authors: Savaya Danijela , El-Khoury Jessica R.
Published: April 2023

This study reports that lack of sexual education in schools influences adolescents to use the Internet to further their interest in sexuality. The study also reveals that seeking information online about sexuality influences adolescent’s attitude, behaviors, and beliefs. The data is exploratory and indicates that the majority of participants never had formal sex education lessons in schools, and they confirmed that the lack of sexual education in schools influences them to use the Internet to further their interests in sexuality by looking up sexual content/information online. In addition, and of great concern is the participant’s lack of knowledge about sexual health and understanding of sexually transmitted infections/diseases. It is clear from this study that there is a positive correlation between the use of the Internet to gratify adolescents’ needs for information about sexuality and influence on their attitudes, beliefs, and behaviors. This study adds to the theoretical understanding of uses and gratifications and the social learning theory, as well as to the practical aspect as an advocate for adolescents’ actual wants, needs and associated beliefs, attitudes and behaviors, all of which can be used to derive a sexual education program in schools and media that can better and accurately inform young individuals about decisions impacting their lives/health both on the short and long-term.
Stigmatizing Responses to Chrissy Teigen’s Pregnancy Loss Disclosure on Twitter
Authors: Schneider Abbey , Kosenko Kami
Published: April 2023

When celebrity Chrissy Teigen shared on social media that she had experienced a pregnancy loss, she received support and heavy criticism from those who questioned her decision to disclose and grieve in public. This study examined these critiques and framed these messages as constitutive of pregnancy loss stigma. A thematic analysis of 300 stigmatizing tweets revealed that these messages were marked by one or more of six features, including accusations of over-sharing, blame, questions about the photos that were shared, expressions of disgust, denunciations of the disclosure as attention-seeking behavior, and tu quoque arguments. These findings suggest the need for further research on topics such as strategic topic avoidance, grief gaslighting, and bereavement photography.
Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk
Authors: Rajkovic Katarina , Drobac Milica , Milic Petar , Vucic Vesna , Arsic Aleksandra , Peric Mirijana , Radunovic Milena , Jeremic Sanja , Arsenijevic Jelena
Published: April 2023

Juglans nigra (Black walnut) is a source of health-supporting biologically active compounds used in traditional medicine. The investigation of bioactive compounds in black walnut could lead to its broader application, as well as to the application of its by-products. Therefore, this study aimed to characterize J. nigra nut and green husk based on chemical analysis of their petroleum ether and ethanol extracts obtained by ultrasonic and reflux extraction methods, respectively. Different extract fractions were tested for their antimicrobial activities using Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), Gram-positive bacteria (Enterococcus faecalis, Staphylococcus aureus) and yeast (reference strain and clinical isolates of Candida albicans). The ethanol extracts analysis, performed by high performance liquid chromatography, singled out the ellagic acid as the most dominant compound in nut ((55.0?1.3)?10-3 kg m-3) and green husk ((114.1?0.5)?10-3 kg m-3) extracts. Non-polar compounds were evaluated using gas chromatography analysis of petroleum ether extracts. Juglans nigra nut and green husk contained two saturated fatty acids, palmitic acid (C16:0) and stearic acid (C18:0), then, monounsaturated fatty acids, palmitoleic (C16:1n-7), oleic (C18:1n-9) and vaccenic acid (C18:1n-7), as well as polyunsaturated fatty acids, linoleic (C18:2n- -6), ?-linolenic (C18:3n-6) and ?-linolenic (C18:3n-3) acids. Ethanol extracts of both J. nigra nut and green husk showed antimicrobial activity against C. albicans, which is the most common cause of yeast infections.
Efficacy of removing calcium hydroxide deposits from endodontic instruments prior to sterilization using different cleaning methods
Authors: Popovic Jelena , Nikolic Marija , Mitic Aleksandar , Stosic Nenad , Barac Radomir , Stankovic Antonije , Milovanovic Aleksandra
Published: April 2023

Introduction. Endodontic instruments during root canal treatment come into
contact with dentinal debris, irrigation solutions and medication agents,
which reminants should be eliminated before sterilization. The aim of the
study was to verify the effectiveness of different cleaning methods for
removing calcium hydroxide paste residues from the surfaces of the working
parts of hand instruments, as well as to propose an effective protocol for
cleaning endodontic instruments before sterilization. Material and methods.
Forty-two new hand endodontic instruments were used to remove calcium
hydroxide paste from the filled canals of extracted teeth. After
contamination with medication, they were divided into the four groups and
subjected to individual decontamination methods - mechanical, chemical and
ultrasonic, as well as a combined protocol. The instruments were then
observed under a light microscope. The effectiveness of the methods was
evaluated based on the amount of residual matter on the surface of the
working parts of the instruments. Results. The combined protocol showed a
statistically significant difference in the achieved level of cleanliness
compared to mechanical (?2 = 12.00 p < 0.05) and chemical methods (?2 =
12.00 p < 0.05), but there was no statistically significant difference
compared to ultrasonic cleaning in disinfectant solution (?2 = 2.4 p >
0.05). By applying combined protocol, instruments with completely clean
surfaces were found, as well as the lowest values of contamination at the
level of the entire group of instruments (8.33%). Conclusion. The protocol
that consisted of mechanical cleaning with a sponge soaked in chlorhexidine
gluconate, chemical soaking in sodium hypochlorite, and ultrasonic cleaning
in a disinfectant showed the best efficiency in removing calcium hydroxide
residues.
Vascular endothelial growth factor as a response of denture bearing tissues on mechanical stress in diabetes mellitus
Authors: Radovic Katarina , Brkovic Bozidar , Ilic Jugoslav , Milic-Lemic Aleksandra , Jovanovic Tamara , Jovanovic Boris , Roganovic Jelena
Published: April 2023

Introduction. Vascular endothelial growth factor (VEGF) is signal molecule
enrolled in diabetes mellitus type 2 (DM type 2) oral complications, but
there are no studies showing the relation between VEGF and pressure caused
by denture wearing in diabetic conditions. The aim of this study is to
compare tissue VEGF levels in patients and animals with/without DM in
conditions of chronic and acute pressure. Methods. Research was conducted on
DM type 2 and healthy partial denture wearers for more than 5 years (78),
candidates for teeth extractions and experimental animals of the Wistar rats
(40). For chronic conditions, VEGF was measured in 2 mucosal samples covered
and not covered by denture in all denture wearers. Demonstrating acute
conditions, after 3 days of wearing experimental plate VEGF was measured in
2 gingival samples of palatal mucosa of DM (20) and control rats (20). The
concentrations of VEGF (pg/ml) in human and animal tissues were measured by
commercially available ELISA kit. Results. Tissue VEGF levels in control and
diabetic partial denture wearers not covered by denture were without
statistical difference. In comparison to noncovered tissue, VEGF decreased
in samples covered by denture, being significantly lower in DM type 2,
comparing to healthiest. VEGF levels in palatal mucosa without palatal base
did not significantly differ in control and DM rats. VEGF levels under
palatal base increased being significantly lower in DM rats comparing to
controls. Conclusion. Both, chronic and acute mechanical stress caused by
wearing palatal denture (plate) decreased the VEGF levels in diabetic
conditions comparing the health?s suggesting the altered homeostasis.
Evaluation of swallowing in transverse maxillary deficiency patients before and after rapid maxillary expansion
Authors: Yalcin Aycan , Aras Isil , Gode Sercan , Durusoy Duygu , Sezgin Baha , Eyigor Sibel , Aras Aynur
Published: April 2023

Objectives

To evaluate swallowing function in relation to oropharyngeal dysphagia (OD) in adolescents who had transverse maxillary deficiency with posterior crossbite and high-arched palate, before, and after rapid maxillary expansion (RME).

Materials and Methods

Twenty patients (mean age: 13.0 ± 3.1) with bilateral posterior crossbite and high-arched palate (RME group: RMEG) and 20 volunteers (mean age: 13.4 ± 2.6) with Class I crowding without posterior crossbite or high-arched palate (control group: CG) were recruited. OD signs and symptoms were evaluated using the Eating Assessment Tool-10 (EAT-10) questionnaire, patient complaints, and physical examination of swallowing function before (T1) and 7 months after (T2) RME. Additionally, fiberoptic endoscopic evaluation of swallowing (FEES) with water, yogurt, and cracker was performed. In CG, evaluation of swallowing was performed only once, corresponding to T1 of RMEG.

Results

Prevalence of OD signs and symptoms based on patient complaints and physical examination of swallowing was low (5%–15%), and nonsignificant differences were observed between CG and RMEG at T1 for these parameters as well as for EAT-10 scores. Total post-swallow pharyngeal residue with yogurt was significantly different between CG and RMEG at T1, with a prevalence of 60% in RMEG (P < .05). There was no significant difference regarding residue with yogurt between T1 and T2 in RMEG (P > .05).

Conclusion

Patients with a maxillary transverse deficiency were affected by pharyngeal residue as indicated by FEES, but it did not appear to improve in short-term follow-up in patients treated with RME.
Long noncoding RNA PPT2-EGFL8 regulates pathological retinal neovascularization in PDR by functioning as a competing endogenous RNA
Authors: Xu Zifan , Yang Jiahui , Zheng Haohan , Xie Tianhua , Yang Qian , Cai Jiping , Sun Chao , Cao Yujuan , Wu Meili , Liu Yanqiu , Cui Yuqing , Yao Yong , Wang Xiaolu
Published: April 2023

  

Diabetic retinopathy (DR) is a common complication in patients with diabetes, and PDR has become an important cause of blindness; however, the mechanisms involved have not been fully elucidated. Long noncoding RNAs (lncRNAs) and microRNAs can play an important role in DR, and they can accurately regulate the expression of target genes through a new regulatory model: competing endogenous RNAs (ceRNAs). We isolated total RNA of extracellular vesicles (EVs) in the serum of healthy individuals (Con) and individuals with diabetes mellitus without DR (DM-NDR), non-proliferative DR (NPDR), or proliferative DR (PDR), and subjected them to deep sequencing. We found aberrantly low expression of PPT2-EGFL8, and significantly increased level of miR-423-5p. PPT2-EGFL8 adsorbs miR-423-5p as a molecular sponge, and inhibits hypoxia-induced hRMEC proliferation. In an oxygen-induced retinopathy (OIR) model and a streptozotocin (STZ)-induced diabetic model, Egfl8-OE treatment reduces diabetes-related reactive gliosis, inflammation and acellular capillaries, attenuates the development of pathological neovascularization. In addition, PPT2-EGFL8 targeting miR-423-5p plays an important role in hypoxia-induced PPARD/ANGPTL4 signaling activation, especially the expression of C-terminal (cANGPTL4) fragment. Finally, ANGPTL4 significantly induces retinal vessel breakage in the inner limiting membrane (ILM) and facilitate retinal vessel sprouting into the vitreous in the OIR mice. Thus, either new biomarkers or new therapeutic targets may be identified with translation of these findings.
Translation of specialized vocabulary in popular science writing
Authors: Алипичев А.Ю. , Порческу Г.В. , Сергеева Н.А.
Published: April 2023

Авторы рассматривают роль специальной лексики в научно-популярном тексте и основные способы ее перевода на примере медицинского текста на английском языке. В статье представлены результаты анализа лексики по стратификационному, содержательному, структурному и морфолого-синтаксическому принципам, а также способу словообразования; описаны наиболее часто применяемые трансформации при переводе специальной лексики с английского языка на русский

The authors consider the role of specialized vocabulary in popular science writing and the translation techniques as exemplified by specialized vocabulary used in English medical science articles. The authors describe the results of the vocabulary analysis based on the stratification, content, structural, morphological-syntactic, and word formation principles. They also analyze the most common translation techniques used by the translators when translating specialized vocabulary in medical popular science articles into Russian.
The image of seeing-off to the war (ritual actions, prohibitions and omens) in oral stories about the Great Patriotic War
Authors: Лицарева А.Ф.
Published: April 2023

В статье рассматриваются, систематизируются и анализируются обрядовые действия, запреты и приметы, связанные с проводами в армию и на фронт. Материал исследования – рассказы о Великой Отечественной войне – демонстрирует значимость данной темы в российской культуре. Группы действий, связанных с проводами в армию, проиллюстрированы примерами. Соблюдение традиции проводов способствовало тому, что воин возвращался домой живым. Методы сбора и анализа данных: анкетирование (работа с вопросниками), глубинные интервью; сопоставительное изучение текстов. Сделан обзор актуальной литературы по данной теме. Показаны перспективы развития: сравнение проводов на фронт в годы Великой Отечественной войны и во время последующих локальных войн.

The article examines, systematizes and analyzes ritual actions, prohibitions and omens associated with seeing-off to the army and to the front. The research material – stories about the Great Patriotic War – demonstrates the importance of this topic in Russian culture. All of groups of actions related to seeing-off to the army are illustrated with interesting examples. Observing the tradition of seeing-off a warrior contributed to his return home alive. Research methods of data collection and analysis: questionnaires (work with questionnaires), in-depth interviews; comparative study of texts. A review of significant literature on this topic is made. The prospects for the development of the topic are shown: comparison of seeing-off to the front line during the Great Patriotic War and during subsequent local wars.
Verbal representation of the interpreter's language personality: syntactic aspect
Authors: Уланова Е.Э.
Published: April 2023

В статье представлены результаты исследования феномена языковой личности устного переводчика в ситуации перевода с позиции лингвокогнитивного подхода. Также описываются вербальные репрезентации языковой личности устного переводчика в языковой паре «английский-русский» с точки зрения синтаксиса, анализируются синтаксические искажения и их влияние на вербальную репрезентацию языковой личности.

The author considers the phenomenon of the interpreter's language personality in the situation of interpretation in terms of linguocognitive approach. The article describes the verbal representation of the interpreter's language personality in the working language pair English vs. Russian from the viewpoint of syntax, analyzes syntactic interference and their influence on the verbal representation of language personality.
Teacher’s readiness to develop and use interactive materials in professional activities
Authors: Голанова А.В. , Голикова Е.И.
Published: April 2023

Статья посвящена проблеме оценки готовности педагога к работе с интерактивными учебными материалами. Определено понятие «интерактивный учебный материал». Приведены виды интерактивных учебных материалов. Рассмотрены программные средства, которые возможно использовать для создания интерактивных учебных материалов, приведены критерии их выбора и обоснован выбор наиболее подходящих для создания интерактивных учебных материалов. Уточнена общепедагогическая составляющая профессиональной педагогической ИКТ-компетентности, определяющая готовность педагога к созданию и применению интерактивных учебных материалов. Приведен опрос для самостоятельной оценки уровня готовности к созданию и применению интерактивных учебных материалов.

The article focuses on the problem of assessing the teacher’s readiness to work with interactive learning materials. The authors define the concept of "interactive learning material" and describe the types of interactive learning materials. The software tools that can be applied to develop interactive learning materials are considered, the criteria for their selection are provided, and the choice of the most suitable ones for developing interactive learning materials is substantiated. The authors also clarify general pedagogical component of professional pedagogical ICT competence, which determines the teacher’s readiness to develop and use interactive learning materials. A survey is provided for self-assessment of the readiness level for the development and use of interactive learning materials.
Mechanisms for managing the education quality based on the assessment of the student's professional development
Authors: Закиева Р.Р.
Published: April 2023

В данном исследовании анализируется критерий оценки качества образования на примере технического университета. Качество образования основано на оценке и мониторинге профессионального развития студента с использованием цифровых ресурсов. Таким образом, обеспечивается тесное взаимодействие полученных результатов с требованиями к выпускнику, указанными в федеральных государственных образовательных стандартах высшего образования по конкретной (инженерной) специальности. С учётом этих показателей происходит корректировка дидактических условий профессионального и личностного развития обучающихся. Полученные факты обрабатывались с помощью специальной компьютерной программы, хранение, поиск и обработка которой реализованы в информационной системе оценки профессионального развития студентов. Обобщение опыта позволяет регулировать условия развития отдельных компетенций и представить механизм управления качеством образования. Данный механизм включает мониторинг и оценку профессионального развития студентов, анализ образовательной ситуации и принятие решений о корректировке содержания и методов подготовки будущих специалистов- инженеров.

The essence of the study is to apply the quality management system of education at a technical university based on the criteria-based assessment and monitoring of a student's professional development using digital resources, which provides a more continuous comparison of this information with the requirements for a graduate specified in the federal state educational standards of higher education for a specific (engineering) specialty, and adjustment of didactic conditions for students’ professional and personal development. The obtained facts were processed applying a special computer program; the storage, search and processing of which are implemented in the information system for assessing the students’ professional development. Summarizing the experience of "adjusting" the conditions for the development of individual competencies allowed us to present a mechanism for managing the quality of education based on the assessment of the student's professional development, including monitoring and evaluation of students' professional development, analysis of the educational situation and decision-making on adjusting the content and methods of future engineer training.