bluuebunny/crossref_metadata_2025 huggingface dataset:
Direct observation of procedural skills (DOPS) assessment in diagnostic gastroscopy: nationwide evidence of validity and competency development during training
Authors:   The Joint Advisory Group on Gastrointestinal Endoscopy (JAG), Siau Keith , Crossley James , Dunckley Paul , Johnson Gavin , Feeney Mark , Hawkes Neil D. , Beales Ian L. P.
Published: March 2019

Background

Validated competency assessment tools and the data supporting milestone development during gastroscopy training are lacking. We aimed to assess the validity of the formative direct observation of procedural skills (DOPS) assessment tool in diagnostic gastroscopy and study competency development using DOPS.

Methods

This was a prospective multicentre (N = 275) analysis of formative gastroscopy DOPS assessments. Internal structure validity was tested using exploratory factor analysis and reliability estimated using generalisability theory. Item and global DOPS scores were stratified by lifetime procedure count to define learning curves, using a threshold determined from receiver operator characteristics (ROC) analysis. Multivariable binary logistic regression analysis was performed to identify independent predictors of DOPS competence.

Results

In total, 10086 DOPS were submitted for 987 trainees. Exploratory factor analysis identified three distinct item groupings, representing ‘pre-procedure’, ‘technical’, and ‘post-procedure non-technical’ skills. From generalisability analyses, sources of variance in overall DOPS scores included trainee ability (31%), assessor stringency (8%), assessor subjectivity (18%), and trainee case-to-case variation (43%). The combination of three assessments from three assessors was sufficient to achieve the reliability threshold of 0.70. On ROC analysis, a mean score of 3.9 provided optimal sensitivity and specificity for determining competency. This threshold was attained in the order of ‘pre-procedure’ (100–124 procedures), ‘technical’ (150–174 procedures), ‘post-procedure non-technical’ skills (200–224 procedures), and global competency (225–249 procedures). Higher lifetime procedure count, DOPS count, surgical trainees and assessors, higher trainee seniority, and lower case difficulty were significant multivariable predictors of DOPS competence.

Conclusion

This study establishes milestones for competency acquisition during gastroscopy training and provides validity and reliability evidence to support gastroscopy DOPS as a competency assessment tool.
Aortic Bulge: A Possible Predictive Sign of Impending Aortoenteric Fistula
Authors: Kennedy Patrick , Monteiro Sandra , Yip Gordon , Gastaldo Fernando
Published: March 2019

Purpose

The purpose of this study is to introduce the aortic bulge sign, a finding observed retrospectively on computed tomography prior to the acute presentation of aortoenteric fistula, and to determine its interobserver reliability.

Methods

Following research ethics board approval, all cases of aortoenteric fistula at our institution occurring from 2011–2015 were identified retrospectively. All previous computed tomography images of patients who eventually developed aortoenteric fistula were reviewed by a single observer for the presence of a potentially predictive finding of fistulization, the aortic bulge sign. These previous images were then combined with age and sex matched controls into a case bank. Eight radiology residents and staff were instructed in observing the aortic bulge sign. These observers then reviewed the case bank in a blinded analysis to determine the interobserver reliability of this finding.

Results

Fourteen cases of aortoenteric were identified. The average patient age was 70.71 years with a male-to-female ratio of 11:3. Eleven patients had previous computed tomography images available for review. With blinded analysis by multiple observers, the aortic bulge sign was identified with greater than 80% agreement in six of 11 cases (66.67%). Fleiss' kappa was calculated at k = 0.60 (95% confidence interval 0.50–0.69), corresponding to moderate-to-substantial interobserver agreement.

Conclusions

The aortic bulge sign has been retrospectively identified as a promising computed tomography finding of eventual aortoenteric fistula prior to acute presentation. Further study is required to determine the diagnostic value of this sign.
Factors Associated with Having a Will, Power of Attorney, and Advanced Healthcare Directive in Patients Presenting to a Rural and Remote Memory Clinic
Authors: Lee Sydney , Kirk Andrew , Kirk Emily A. , Karunanayake Chandima , O’Connell Megan E. , Morgan Debra
Published: March 2019

Background: A Will, Power of Attorney, and Advanced Healthcare Directive are critical to guide decision-making in patients with dementia. We identified characteristics that are associated with the existence of these documents in patients who presented to a rural and remote memory clinic (RRMC). Methods: Ninety-five consecutive patients were included in this study. Patients and caregivers completed questionnaires on initial presentation to the RRMC and patients were asked if they had legal documents. Patients also completed neuropsychological testing. Statistical analysis (t-test and χ2 test) was performed to identify significant variables. Results: Seventy (73.7%) patients had a Will, 62 (65.3%) had a Power of Attorney, and 21 (22.1%) had an Advanced Healthcare Directive. Having a Will was associated with good quality of life (p = 0.001), living alone or with a spouse or partner only (p = 0.034), poor verbal fluency (p = 0.055), and European ethnicity (p = 0.028). Factors associated with having a Power of Attorney included good quality of life (p = 0.031), living alone or with a spouse or partner only (p = 0.053), and poor verbal fluency (p = 0.015). Old age (p = 0.015), poor verbal fluency (p = 0.023), and greater severity of cognitive and functional impairment (p = 0.023) were associated with having an Advanced Healthcare Directive. Conclusions: Our results indicate that poor quality of life, good performance on verbal fluency, Indigenous ethnicity, and living with others are associated with a lower likelihood of legal documents in patients with dementia. These factors can help physicians identify patients at risk of leaving their legal affairs unattended to. Physicians should discuss the creation of legal documents early on in patients with signs of dementia.
Effect of Head Rotation on Jugular Vein Patency Under General Anesthesia
Authors: Burbridge Mark A. , Min Jung Gi , Jaffe Richard A.
Published: March 2019

Head rotation causes compression and occlusion of the ipsilateral internal jugular (IJ) vein. This can result in raised intracranial pressure and increased bleeding if the patient is having or has recently had surgery. The amount of head rotation in adults resulting in occlusion of the ipsilateral IJ vein is unknown however. We measured the amount of head turn that produced occlusion of the ipsilateral IJ vein in 25 patients having surgery under general anesthesia. On average, 80% of IJ veins occlude at a mean of 55.6° on the left and 53.3° on the right.
On Bragg resonances and wave triad interactions in two-layered shear flows
Authors: Raj Raunak , Guha Anirban
Published: March 2019

The standard resonance conditions for Bragg scattering as well as weakly nonlinear wave triads have been traditionally derived in the absence of any background velocity. In this paper, we have studied how these resonance conditions get modified when uniform, as well as various piecewise linear velocity profiles, are considered for two-layered shear flows. Background velocity can influence the resonance conditions in two ways: (i) by causing Doppler shifts, and (ii) by changing the intrinsic frequencies of the waves. For Bragg resonance, even a uniform velocity field changes the resonance condition. Velocity shear strongly influences the resonance conditions since, in addition to changing the intrinsic frequencies, it can cause unequal Doppler shifts between the surface, pycnocline and the bottom. Using multiple scale analysis and Fredholm alternative, we analytically obtain the equations governing both the Bragg resonance and the wave triads. We have also extended the higher-order spectral method, a highly efficient computational tool usually used to study triad and Bragg resonance problems, to incorporate the effect of piecewise linear velocity profile. A significant aspect, both on the theoretical and numerical fronts, has been extending the potential flow approximation, which is the basis of the study of these kinds of problems, to incorporate piecewise constant background shear.
The Sensitivity of Spatial Regression Models to Network Misspecification
Authors: Juhl Sebastian
Published: March 2019

Spatial econometric models become increasingly popular in various subfields of political science. However, the necessity to specify the underlying network of dependencies, denoted by $\boldsymbol{W}$, prior to estimation is a prevalent source of criticism since the true dependence structure is rarely known and theories mostly provide insufficient guidance. The present study investigates the effects of thisnetwork uncertaintywhich is a special case of model uncertainty that arises from uncertainty about the correct specification of $\boldsymbol{W}$. It advocates Bayesian model averaging (BMA) as a superior approach to this problem, located at the intersection of theory and empirics. Conducting Monte Carlo experiments, I demonstrate that, while the effect estimates are robust toward a misspecification in the functional form of $\boldsymbol{W}$, uncertainty in the neighborhood definition can bias the effect estimates derived from spatial autoregressive models. In contrast to alternative techniques, BMA directly addresses network uncertainty, correctly identifies the true network structure in the set of feasible alternatives, and provides unbiased effect estimates. Two replication studies from different subfields of the discipline illustrate the benefits of this approach for applied research.
Bridging Spatial and Saliency Theory: Party Size and Issue Selection in Campaigns
Authors: Basu Chitralekha
Published: March 2019

I propose a unified explanation for parties' joint policy and emphasis decisions which bridges saliency theory and spatial analyses of party campaigns. Party platforms are anchored by the policy preferences of activists, core supporters and target voters, leading parties to disproportionately emphasize issues where their policies are popular with all key constituencies. However, which voters a party targets relates to its historical electoral performance (“party size”). Traditionally successful (“major”) parties emphasize issues where the policies preferred by activists and core supporters are generally popular, but smaller (“minor”) parties emphasize issues where their preferred policies may be unpopular but are distinctive. Using recent European data and various empirical strategies, I show that this account has significant explanatory power beyond existing party typologies and theories of issue selection.
An assessment of grazing management options for Mediterranean grasslands using Noy-Meir's model of system dynamics parameterized from a long-term field trial
Authors: Seligman N. G. , Ungar E. D. , Perevolotsky A. , Henkin Z.
Published: March 2019

Noy-Meir's simple but insightful model of grazing-system dynamics was used to draw broader inferences from empirical data generated by a 17-year field trial with beef cattle grazing a Mediterranean grassland in northern Israel. After calibration of its parameters against the field results, the model predictions were tested against an independent set of data obtained from the study site; they were within acceptable deviations from the inherently noisy field data. The calibrated model was used to analyse the effects of changes to two key grazing-management factors – stocking density and early-season grazing deferment – on biomass dynamics and forage consumption. The simulated results were used to calculate forage deficits and supplementary feed requirements for optimum herd performance during the growth (‘green’) season and throughout the year. The results revealed a critical stocking density of 0.7 Animal Units (AU)/ha, above which early-season deferment reduced the amount of supplementary feed required to maintain the optimum production of the herd. Optimum stocking is higher when the grassland is used mainly in the highly nutritious green season. Responses of the strongly seasonal Mediterranean grassland to the interaction between stocking density and early-season grazing deferment were expressed by a calibrated model, in terms that determine the efficiency of forage supplementation of the herd during the green season and throughout the year.
What's wrong with Tooley's argument from evil?
Authors: MILLER CALUM
Published: March 2019

Michael Tooley has recently advanced a novel formulation of the problem of evil. The argument primarily intends to address sceptical theist responses to the problem of evil by giving a theoretical argument that prima facie evils are probably ultima facie evils. He thus argues from a single prima facie evil to the conclusion that God probably does not exist, before extending his argument to encompass many prima facie evils using Carnapian inductive logic. In this article I respond to Tooley's two arguments. I improve the first by clearing up some ambiguities, before noting a variety of problems. In particular, the fatal problem is that, contra Tooley, the occurrence of some event is in fact evidence that such an event is not in fact impermissible for God to allow. I then challenge Tooley's extension using Carnapian induction, offering a parody which suggests that Carnapian induction of this variety leads to manifestly absurd results.
Asymptotic behaviour of solutions of Fisher–KPP equation with free boundaries in time-periodic environment
Authors: CAI JINGJING , XU LI
Published: March 2019

We study a free boundary problem of the form: ut = uxx + f(t, u) (g(t) < x < h(t)) with free boundary conditions h′(t) = −ux(t, h(t)) – α(t) and g′(t) = −ux(t, g(t)) + β(t), where β(t) and α(t) are positive T-periodic functions, f(t, u) is a Fisher–KPP type of nonlinearity and T-periodic in t. This problem can be used to describe the spreading of a biological or chemical species in time-periodic environment, where free boundaries represent the spreading fronts of the species. We study the asymptotic behaviour of bounded solutions. There are two T-periodic functions α0(t) and α*(t; β) with 0 < α0 < α* which play key roles in the dynamics. More precisely, (i) in case 0 < β< α0 and 0 < α < α*, we obtain a trichotomy result: (i-1) spreading, that is, h(t) – g(t) → +∞ and u(t, ⋅ + ct) → 1 with $c\in (-\overline{l},\overline{r})$, where $ \overline{l}:=\frac{1}{T}\int_{0}^{T}l(s)ds$, $\overline{r}:=\frac{1}{T}\int_{0}^{T}r(s)ds$, the T-periodic functions −l(t) and r(t) are the asymptotic spreading speeds of g(t) and h(t) respectively (furthermore, r(t) > 0 > −l(t) when 0 < β < α < α0; r(t) = 0 > −l(t) when 0 < β < α = α0; $0 \gt \overline{r} \gt -\overline{l}$ when 0 < β < α0 < α < α*); (i-2) vanishing, that is, $\lim\limits_{t \to \mathcal {T}}h(t) = \lim\limits_{t \to \mathcal {T}}g(t)$ and $\lim\limits_{t \to \mathcal {T}}\max\limits_{g(t)\leq x\leq h(t)} u(t,x)=0$, where $\mathcal {T}$ is some positive constant; (i-3) transition, that is, g(t) → −∞, h(t) → −∞, $0<\lim\limits_{t \to \infty}[h(t)-g(t)] \lt +\infty$ and u(t, ⋅) → V(t, ⋅), where V is a T-periodic solution with compact support. (ii) in case β ≥ α0 or α ≥ α*, vanishing happens for any solution.
Multiple congenital ventricular diverticula causing heart failure
Authors: Saraçoğlu Erhan , Kılıç Salih , Kuzu Zülfiye
Published: March 2019

This paper reports a case of multiple congenital ventricular diverticula, a rare anomaly that is associated with heart failure.
Patient characteristics and incidence of childhood hospitalisation due to hypertrophic cardiomyopathy in the United States of America 2001–2014
Authors: Sakai-Bizmark Rie , Webber Eliza J. , Marr Emily H. , Mena Laurie A. , Chang Ruey-Kang R.
Published: March 2019

This study investigated patient characteristics in paediatric hospitalisations for hypertrophic cardiomyopathy. We used Nationwide Inpatient Sample, which is the largest all-payer inpatient database in the United States, yielding nationally representative estimates, from 2001 to 2014. ICD-9-CM diagnostic codes identified hospitalisations for patients with hypertrophic cardiomyopathy and <18 years. Outcomes included yearly rate of hospitalisation, death, admission via emergency department, and need for surgery. Predictors of interest were age groups (<1, 1–9, and ⩾10 y/o), sex, and race/ethnicity. Logistic regression modelled associations, adjusted by patient- and hospital-level variables. With 2302 weighted hospitalisations, hospitalisation rates were 0.22 per 100,000 children/year, with higher rates for <1 y/o (0.42) and ⩾10 y/o (0.31). Male-to-female ratios were more prominent in the oldest age group; 2.7:1 in ⩾10 y/o versus less than 1.7:1 for <10 y/o. In-hospital mortality was 1.5%, with highest mortality rates among the <1 y/o (6.3%). Children ⩾10 y/o had 5.59 times higher risk of admission from the emergency department than 1–9 y/o age group. Both ⩾10 and <1 y/o age groups had lower risk of surgical intervention compared to the 1–9 y/o group with odds ratio 0.56 and 0.26, respectively. Black children had higher risk of admission from the emergency department than White children with odds ratio 2.78. A relation between age group and sex was observed, with sex-based differences in prevalence and treatment of hypertrophic cardiomyopathy becoming more pronounced with age. Further studies are needed to clarify mechanisms behind age and racial disparity in hospitalisation, especially admission source.
Teaching Women/Gender and Politics: Current Trends and Challenges
Authors: Han Lori Cox , Heldman Caroline
Published: March 2019

The study of women and US politics, as well as the role that gender plays in the broader political context, represents a significant contribution to the discipline of political science. Undergraduate courses on women/gender and politics continue to evolve as more innovative pedagogical approaches emerge. We considered the current trends and challenges related to teaching an undergraduate women/gender and politics course within political science. Through a survey of instructors, we assessed contemporary pedagogical approaches that reflect common learning outcomes, instructional resources that are available to undergraduate instructors, and challenges that instructors face in both offering and teaching this course. We found that institutions generally consider women/gender and politics courses to be tertiary parts of the curriculum and that a majority of faculty who teach these courses face pushback from students in ways that dismiss the importance of studying gender as a variable in political science.
Making Interpretivism Visible: Reflections after a Decade of the Methods Café
Authors: Funk Kevin
Published: March 2019

More than a decade after the observation that an “interpretive turn” was percolating through political science, there are clear indications of growth in the perceived legitimacy of interpretive scholarship. Both accompanying and contributing to interpretivism’s ascent has been the regular staging of Methods Cafés at various conferences in and beyond the discipline. First held at the 2005 meeting of the Western Political Science Association, the Methods Café subsequently landed at the 2006 conference of the American Political Science Association. The Methods Café has become an institutionalized feature of these and other conferences. This reflection looks at the past, present, and future of these events, as well as the key role they have played in making interpretivism visible in the discipline. In particular, I highlight their function as non-hierarchical intellectual spaces that promote teaching, learning, and interpretivist community building. Further, I offer friendly but not uncritical commentary on the successes and limitations of the Methods Café.
A comparison of the Health Star Rating and nutrient profiles of branded and generic food products in Sydney supermarkets, Australia
Authors: Kim Dong Hun , Liu Wing Gi Amanda , Rangan Anna , Gemming Luke
Published: March 2019

Objective

To compare the Health Star Rating (HSR) and the nutritional profile of branded and generic packaged foods in Australia.

Design

In-store audits of packaged food products capturing data on HSR and nutritional content to analyse differences between branded and generic foods across ten food categories.

Setting

The audit was conducted in four major supermarket chains across various locations within metropolitan Sydney regions, Australia.

Results

A total of 6269 products were analysed with 57 % of generic products and 28 % of branded products displaying an HSR. The median HSR of branded products was significantly greater than for generic products overall (4·0 v. 3·5, P<0·005) and in six out of ten food categories (P<0·005). However, when branded products could be matched to their generic counterparts for paired comparisons (n 146), no statistical difference was observed in all ten food categories. Branded products that chose to display an HSR had significantly lower saturated fat and Na, but higher fibre contents than branded products not displaying an HSR.

Conclusions

Our data show no difference in the HSR or nutrient profiles of similar branded and generic products that display HSR. Branded products appear to exploit the voluntary nature of the HSR scheme, preferentially displaying an HSR on healthier products compared with their generic counterparts.
Direct marketing channel choices among US farmers: evidence from the Local Food Marketing Practices Survey
Authors: Plakias Zoë T. , Demko Iryna , Katchova Ani L.
Published: March 2019

Due to strong interest in local foods by US consumers, farmers are now marketing not only to traditional wholesale outlets but also via short supply chains to consumers, grocers, restaurants, schools and other local intermediaries. Our research questions are: (1) what farm and farmer characteristics predict farmers’ participation in various direct marketing channels, and (2) what farm and farmer characteristics predict farmers’ choice of a particular combination of direct marketing channels? This work is important because prior research suggests that while total direct sales via short supply chains continue to grow, direct-to-consumer sales (e.g. via farmers’ markets and Community Support Agriculture, or CSAs) are plateauing. Our work highlights key relationships and implies potential barriers and opportunities for farmers in this maturing local foods landscape. To answer our research questions empirically, we employ the 2015 Local Food Marketing Practices Survey, collected by USDA in 2016, and binomial and multinomial logit regressions. Our research yields a number of useful results. For example, we find evidence suggesting the existence of product-specific barriers to participation in certain channels; livestock producers are less likely than other farmers to sell directly to retailers, whereas vegetable farmers are less likely to sell to intermediaries. We also find that beginning farmers are more likely to sell directly to retailers, but less likely to sell to intermediaries than more established farmers, suggesting potential barriers and opportunities for entry into this channel for less experienced farmers. These insights suggest potential areas of attention for policymakers and other decisionmakers, as well as areas for future study.
A low-phase noise D-band signal source based on 130 nm SiGe BiCMOS and 0.15 µm AlGaN/GaN HEMT technologies
Authors: Do Thanh Ngoc Thi , Bao Mingquan , He Zhongxia Simon , Hassona Ahmed , Kuylenstierna Dan , Zirath Herbert
Published: March 2019

This paper reports on a record-low-phase noise D-band signal source with 5 dBm output power, and 1.3 GHz tuning range. The source is based on the unconventional combination of a fundamental frequency 23 GHz oscillator in 150 nm AlGaN/GaN HEMT technology followed by a 130 nm SiGe BiCMOS MMIC including a sixtupler and an amplifier. The amplifier operates in compression mode as power-limiting amplifier, to equalize the source output power so that it is nearly independent of the oscillator's gate and drain bias voltages used for tuning the frequency of the source. The choice of using a GaN HEMT oscillator is motivated by the need for a low oscillator noise floor, which recently has been demonstrated as a bottle-neck for data rates in wideband millimeter-wave communication systems. The phase noise performance of this signal source is −128 dBc/Hz at 10 MHz-offset. To the best of the authors’ knowledge, this result is the lowest reported phase noise of D-band signal source.
Development of a model to predict soybean yield loss from dicamba exposure
Authors: Foster Matthew R. , Griffin James L. , Copes Josh T. , Blouin David C.
Published: March 2019

Although dicamba-resistant crops can provide an effective weed management option, risk of dicamba off-site movement to sensitive crops is a concern. Previous research with indeterminate soybean identified 14 injury criteria associated with dicamba applied at V3/V4 or R1/R2 at 0.6 to 280 g ae ha−1. Injury criteria rated on a 0 to 5 scale (none to severe), along with percent visible injury and plant height reduction, and canopy height collected 7 and 15 d after treatment (DAT) were analyzed using multiple regression with a forward-selection procedure to develop yield prediction models. Variables included in the 15 DAT models (in order of selection) for V3/V4 were lower stem base lesions/cracking, plant height reduction, terminal leaf epinasty, leaf petiole droop, leaf petiole base swelling, and stem epinasty, whereas for R1/R2 variables were lower stem base lesions/cracking, terminal leaf chlorosis, leaf petiole base swelling, stem epinasty, terminal leaf necrosis, and terminal leaf cupping. To validate the models, experiments including the same dicamba rates and application timings used in previous research were conducted at two locations. For the variables specific to each model, data collected for the dicamba rates were used to predict yield. For the V3/V4 15 DAT model, predicted yield reduction (compared with the nontreated control for dicamba at 0.6 to 4.4 g ha−1) underestimated or overestimated observed yield reduction by an average of 1 and 3 percentage points. For 8.8 g ha−1, predicted yield reduction overestimated observed yield reduction by 8 points and for 17.5 g ha−1 by 20 points. For the R1/R2 15 DAT model, predicted yield reduction for 0.6 to 4.4 g ha−1 overestimated observed yield reduction by an average of 3 to 5 percentage points. For dicamba at 8.8 g ha−1, predicted yield reduction underestimated observed yield reduction by 8 points and for 17.5 g ha−1 overestimated by 6 points.
Providing Freshmen with a Good	“Starting-Block”
Authors: De Clercq Mikaël , Michel Charlotte , Remy Sophie , Galand Benoît
Published: March 2019

Abstract. Grounded in social-psychological literature, this experimental study assessed the effects of two so-called “wise” interventions implemented in a student study program. The interventions took place during the very first week at university, a presumed pivotal phase of transition. A group of 375 freshmen in psychology were randomly assigned to three conditions: control, social belonging, and self-affirmation. Following the intervention, students in the social-belonging condition expressed less social apprehension, a higher social integration, and a stronger intention to persist one month later than the other participants. They also relied more on peers as a source of support when confronted with a study task. Students in the self-affirmation condition felt more self-affirmed at the end of the intervention but didn’t benefit from other lasting effects. The results suggest that some well-timed and well-targeted “wise” interventions could provide lasting positive consequences for student adjustment. The respective merits of social-belonging and self-affirmation interventions are also discussed.
Attachment Orientations and Adult Alcohol Use Among Those With Childhood Adversities
Authors: Ennis Edel , Trearty Kelly
Published: March 2019

Abstract. Adverse psychological consequences have been associated with both alcohol abstinence and alcohol disorders. The current study considers those who have experienced childhood adversities and examines whether secure attachment orientation represents a protective factor against an increased likelihood of either abstinence/rare alcohol consumption or alcohol disorder diagnosis. Data were used from the National Comorbidity Survey-Revised (NCS-R) ( N = 5,692), a random sample representative of the American population. Adult personal alcohol use was considered in terms of abstinence/rare alcohol use, regular alcohol use, and alcohol disorder diagnosis. Analyses focused on those who had experienced childhood adversities ( N = 2,182) and assessed attachment orientation as a predictor of alcohol use. Within those who had experienced childhood adversities, in comparison with securely attached individuals, both anxiously attached individuals and avoidant attached individuals had a significantly increased likelihood of being in the alcohol disorder diagnosis group as opposed to the regular alcohol consumption group. Avoidant individuals also had a significantly increased likelihood of being in the abstinence/rare alcohol use group. Results are discussed in terms of subgroups (vulnerable individuals and families) that may benefit from supportive interventions, and what format these interventions might take.
Plume‐Induced Breakup of a Subducting Plate: Microcontinent Formation Without Cessation of the Subduction Process
Authors: Koptev Alexander , Beniest Anouk , Gerya Taras , Ehlers Todd A. , Jolivet Laurent , Leroy Sylvie
Published: March 2019

Separation of microcontinents is explained by a ridge jump toward the passive margin as a possible consequence of plume‐induced rheological weakening, ultimately leading to breakup followed by accretion of the oceanic crust along a new spreading center. In contrast to such a purely extensional case, the separation of continental microblocks from the main body of the African plate during its continuous northward motion and subduction under Eurasia is still poorly understood. Our numerical experiments show the thermal and buoyancy effects of mantle plume impingement on the bottom of the continental part of a subducting plate are sufficient to induce separation of an isolated microcontinental block from the main subducting continent, even during induced plate motion necessary for uninterrupted oceanic and continental subduction. Subsequent continental accretion occurs by decoupling upper‐crustal nappes from the newly formed subducting microcontinent, which is in agreement with the Late Cretaceous‐Eocene evolution of the eastern Mediterranean.
Low‐Temperature Plasticity in Olivine: Grain Size, Strain Hardening, and the Strength of the Lithosphere
Authors: Hansen Lars N. , Kumamoto Kathryn M. , Thom Christopher A. , Wallis David , Durham William B. , Goldsby David L. , Breithaupt Thomas , Meyers Cameron D. , Kohlstedt David L.
Published: March 2019

Plastic deformation of olivine at relatively low temperatures (i.e., low‐temperature plasticity) likely controls the strength of the lithospheric mantle in a variety of geodynamic contexts. Unfortunately, laboratory estimates of the strength of olivine deforming by low‐temperature plasticity vary considerably from study to study, limiting confidence in extrapolation to geological conditions. Here we present the results of deformation experiments on olivine single crystals and aggregates conducted in a deformation‐DIA at confining pressures of 5 to 9 GPa and temperatures of 298 to 1473 K. These results demonstrate that, under conditions in which low‐temperature plasticity is the dominant deformation mechanism, fine‐grained samples are stronger at yield than coarse‐grained samples, and the yield stress decreases with increasing temperature. All samples exhibited significant strain hardening until an approximately constant flow stress was reached. The magnitude of the increase in stress from the yield stress to the flow stress was independent of grain size and temperature. Cyclical loading experiments revealed a Bauschinger effect, wherein the initial yield strength is higher than the yield strength during subsequent cycles. Both strain hardening and the Bauschinger effect are interpreted to result from the development of back stresses associated with long‐range dislocation interactions. We calibrated a constitutive model based on these observations, and extrapolation of the model to geological conditions predicts that the strength of the lithosphere at yield is low compared to previous experimental predictions but increases significantly with increasing strain. Our results resolve apparent discrepancies in recent observational estimates of the strength of the oceanic lithosphere.
Geodetic Observations of the 2018 Mw 7.5 Sulawesi Earthquake and Its Implications for the Kinematics of the Palu Fault
Authors: Song Xiaogang , Zhang Yingfeng , Shan Xinjian , Liu Yunhua , Gong Wenyu , Qu Chunyan
Published: March 2019

The ascending and descending interferometric synthetic aperture radar data are used to investigate the fault rupture and slip model of the 2018 Mw 7.5 Sulawesi, Indonesia, earthquake. The best fitting slip model indicates that this earthquake ruptured not only a segment extending the Palu fault to the north but also a northwestern segment offshore. The slip on the onshore fault is predominant left‐lateral strike slip. The slip on the offshore fault is dominated by normal faulting with a maximum slip of ~6.3 m. The newly discovered offshore normal faulting is likely to be the cause of the tsunami after the shock. Combined with previous geomorphic, tectonic, geodetic, and modeling studies, we suggest that the kinematics of the Palu fault maintained the same style of faulting from north to south, which resulted from an oblique extension occurred on an east dipping fault at depths. The deformation pattern of NW Sulawesi is dominated by this slip mechanism.
Publisher Correction: NOS1 S-nitrosylates PTEN and inhibits autophagy in nasopharyngeal carcinoma cells
Authors: Zhu Lingqun , Li Linlin , Zhang Qianbing , Yang Xiao , Zou Zhiwei , Hao Bingtao , Marincola Francesco M , Liu Zhengjun , Zhong Zhuo , Wang Meng , Li Xiaoxuan , Wang Qianli , Li Keyi , Gao Wenwen , Yao Kaitai , Liu Qiuzhen
Published: March 2019

It was brought to the attention of the Editors that there had been an accidental duplication of the western blot images during the preparation of Figs. 1b and c. The authors were notified about the error and have supplied the correct image for Fig. 1c (below). We apologize for any inconvenience this may have caused readers.
Hurricane María tripled stem breaks and doubled tree mortality relative to other major storms
Authors: Uriarte María , Thompson Jill , Zimmerman Jess K.
Published: March 2019

Tropical cyclones are expected to intensify under a warming climate, with uncertain effects on tropical forests. One key challenge to predicting how more intense storms will influence these ecosystems is to attribute impacts specifically to storm meteorology rather than differences in forest characteristics. Here we compare tree damage data collected in the same forest in Puerto Rico after Hurricanes Hugo (1989, category 3), Georges (1998, category 3), and María (2017, category 4). María killed twice as many trees as Hugo, and for all but two species, broke 2- to 12-fold more stems than the other two storms. Species with high density wood were resistant to uprooting, hurricane-induced mortality, and were protected from breakage during Hugo but not María. Tree inventories and a wind exposure model allow us to attribute these differences in impacts to storm meteorology. A better understanding of risk factors associated with tree species susceptibility to severe storms is key to predicting the future of forest ecosystems under climate warming.
Molecular evidence supports a genic capture resolution of the lek paradox
Authors: Dugand Robert J. , Tomkins Joseph L. , Kennington W. Jason
Published: March 2019

The genic capture hypothesis, where sexually selected traits capture genetic variation in condition and the condition reflects genome-wide mutation load, stands to explain the presence of abundant genetic variation underlying sexually selected traits. Here we test this hypothesis by applying bidirectional selection to male mating success for 14 generations in replicate populations of Drosophila melanogaster. We then resequenced the genomes of flies from each population. Consistent with the central predictions of the genic capture hypothesis, we show that genetic variance decreased with success selection and increased with failure selection, providing evidence for purifying sexual selection. This pattern was distributed across the genome and no consistent molecular pathways were associated with divergence, consistent with condition being the target of selection. Together, our results provide molecular evidence suggesting that strong sexual selection erodes genetic variation, and that genome-wide mutation-selection balance contributes to its maintenance.
The Gene ANTHER DEHISCENCE REPRESSOR (ADR) Controls Male Fertility by Suppressing the ROS Accumulation and Anther Cell Wall Thickening in Arabidopsis
Authors: Dai Shu-Yu , Hsu Wei-Han , Yang Chang-Hsien
Published: March 2019

Male sterility in plants is caused by various stimuli such as hormone changes, stress, cytoplasmic alterations and nuclear gene mutations. The gene ANTHER DEHISCENCE REPRESSOR (ADR), which is involved in regulating male sterility in Arabidopsis, was functionally analyzed in this study. In ADR::GUS flowers, strong GUS activity was detected in the anthers of young flower buds but was low in mature flowers. ADR + GFP fusion proteins, which can be modified by N-myristoylation, were targeted to peroxisomes. Ectopic expression of ADR in transgenic Arabidopsis plants resulted in male sterility due to anther indehiscence. The defect in anther dehiscence in 35S::ADR flowers is due to the reduction of ROS accumulation, alteration of the secondary thickening in the anther endothecium and suppression of the expression of NST1 and NST2, which are required for anther dehiscence through regulation of secondary wall thickening in anther endothecial cells. This defect could be rescued by external application of hydrogen peroxide (H2O2). These results demonstrated that ADR must be N-myristoylated and targeted to the peroxisome during the early stages of flower development to negatively regulate anther dehiscence by suppressing ROS accumulation and NST1/NST2 expression.
First exploration of radiation temperatures of the laser spot, re-emitting wall and entire hohlraum drive source
Authors: Ren Kuan , Liu Shenye , Xie Xufei , Du Huabing , Hou Lifei , Jing Longfei , Yang Dong , Zhao Yang , Yan Ji , Yang Zhiwen , Li Zhichao , Dong Jianjun , Yang Guohong , Li Sanwei , Cao Zhurong , Lan Ke , Huo Wenyi , Liu Jie , Ren Guoli , Ding Yongkun , Jiang Shaoen
Published: March 2019

This study explores the radiation field temperatures introduced by the laser spot, the re-emitting wall in a hohlraum and the entire hohlraum drive source. This investigation, which is the first of its kind, is based on the radiation fluxes from the laser spot and the re-emitting wall, which have been accurately measured using time- and space-resolving flux detectors in a recent work, and additional flux data. The temperature difference between the laser spot and the entire hohlraum drive source was 6.08–35.35% of the temperature of the latter throughout the entire laser pulse, whilst that for the re-emitting wall was 3.90–12.81%. The radiation temperature of the cooler re-emitting wall had more influence on the temperature increase of the entire hohlraum drive source than the hot laser-spot temperature, which has been quantitatively discussed. Experimentally, we established the average distributions of the temperature fields of all the emitting sources, namely laser spot and re-emitting wall, of the irradiating fluxes on the capsule region in the hohlraum radiation field. This important progress in the exploration of radiation temperature distributions within a hohlraum will provide a foundation for determination of the irradiating radiation on the capsule and evaluation of capsule symmetry.
Amorphous silicon dioxide nanoparticles modulate immune responses in a model of allergic contact dermatitis
Authors: Palmer Brian C. , Jatana Samreen , Phelan-Dickinson Sarah J. , DeLouise Lisa A.
Published: March 2019

Amorphous silicon dioxide nanoparticles (SiNPs) are ubiquitous, and they are currently found in cosmetics, drugs, and foods. Biomedical research is also focused on using these nanoparticles as drug delivery and bio-sensing platforms. Due to the high potential for skin exposure to SiNPs, research into the effect of topical exposure on both healthy and inflammatory skin models is warranted. While we observe only minimal effects of SiNPs on healthy mouse skin, there is an immunomodulatory effect of these NPs in a model of allergic contact dermatitis. The effect appears to be mediated partly by keratinocytes and results in decreases in epidermal hyperplasia, inflammatory cytokine release, immune cell infiltration, and a subsequent reduction in skin swelling. Additional research is required to further our mechanistic understanding and to validate the extent of this immunomodulatory effect in human subjects in order to assess the potential prophylactic use of SiNPs for treating allergic skin conditions.
Male dominance status regulates odor-evoked processing in the forebrain of a cichlid fish
Authors: Nikonov Alexandre A. , Maruska Karen P.
Published: March 2019

The ability to identify odors in the environment is crucial for survival and reproduction. However, whether olfactory processing in higher-order brain centers is influenced by an animal’s physiological condition is unknown. We used in vivo neuron and local field potential (LFP) recordings from the ventral telencephalon of dominant and subordinate male cichlids to test the hypothesis that response properties of olfactory neurons differ with social status. Dominant males had a high percentage of neurons that responded to several odor types, suggesting broad tuning or differential sensitivity when males are reproductively active and defending a territory. A greater percentage of neurons in dominant males also responded to sex- and food-related odors, while a greater percentage of neurons in subordinate males responded to complex odors collected from behaving dominant males, possibly as a mechanism to mediate social suppression and allow subordinates to identify opportunities to rise in rank. Odor-evoked LFP spectral densities, indicative of synaptic inputs, were also 2–3-fold greater in dominant males, demonstrating status-dependent differences in processing possibly linking olfactory and other neural inputs to goal-directed behaviors. For the first time we reveal social and reproductive-state plasticity in olfactory processing neurons in the vertebrate forebrain that are associated with status-specific lifestyles.
Thickness determines microbial community structure and function in nitrifying biofilms via deterministic assembly
Authors: Suarez Carolina , Piculell Maria , Modin Oskar , Langenheder Silke , Persson Frank , Hermansson Malte
Published: March 2019

Microbial biofilms are ubiquitous in aquatic environments where they provide important ecosystem functions. A key property believed to influence the community structure and function of biofilms is thickness. However, since biofilm thickness is inextricably linked to external factors such as water flow, temperature, development age and nutrient conditions, its importance is difficult to quantify. Here, we designed an experimental system in a wastewater treatment plant whereby nitrifying biofilms with different thicknesses (50 or 400 µm) were grown in a single reactor, and thus subjected to identical external conditions. The 50 and 400 µm biofilm communities were significantly different. This beta-diversity between biofilms of different thickness was primarily caused by deterministic factors. Turnover (species replacement) contributed more than nestedness (species loss) to the beta-diversity, i.e. the 50 µm communities were not simply a subset of the 400 µm communities. Moreover, the two communities differed in the composition of nitrogen-transforming bacteria and in nitrogen transformation rates. The study illustrates that biofilm thickness alone is a key driver for community composition and ecosystem function, which has implications for biotechnological applications and for our general understanding of biofilm ecology.
Leishmania donovani 90 kD Heat Shock Protein – Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity
Authors: Hombach-Barrigah Antje , Bartsch Katharina , Smirlis Despina , Rosenqvist Heidi , MacDonald Andrea , Dingli Florent , Loew Damarys , Späth Gerald F. , Rachidi Najma , Wiese Martin , Clos Joachim
Published: March 2019

Leishmania parasites are thought to control protein activity at the post-translational level, e.g. by protein phosphorylation. In the pathogenic amastigote, the mammalian stage of Leishmania parasites, heat shock proteins show increased phosphorylation, indicating a role in stage-specific signal transduction. Here we investigate the impact of phosphosites in the L. donovani heat shock protein 90. Using a chemical knock-down/genetic complementation approach, we mutated 11 confirmed or presumed phosphorylation sites and assessed the impact on overall fitness, morphology and in vitro infectivity. Most phosphosite mutations affected the growth and morphology of promastigotes in vitro, but with one exception, none of the phosphorylation site mutants had a selective impact on the in vitro infection of macrophages. Surprisingly, aspartate replacements mimicking the negative charge of phosphorylated serines or threonines had mostly negative impacts on viability and infectivity. HSP90 is a substrate for casein kinase 1.2-catalysed phosphorylation in vitro. While several putative phosphosite mutations abrogated casein kinase 1.2 activity on HSP90, only Ser289 could be identified as casein kinase target by mass spectrometry. In summary, our data show HSP90 as a downstream client of phosphorylation-mediated signalling in an organism that depends on post-transcriptional gene regulation.
Early postnatal development of pyramidal neurons across layers of the mouse medial prefrontal cortex
Authors: Kroon Tim , van Hugte Eline , van Linge Lola , Mansvelder Huibert D. , Meredith Rhiannon M.
Published: March 2019

Mammalian neocortex is a highly layered structure. Each layer is populated by distinct subtypes of principal cells that are born at different times during development. While the differences between principal cells across layers have been extensively studied, it is not known how the developmental profiles of neurons in different layers compare. Here, we provide a detailed morphological and functional characterisation of pyramidal neurons in mouse mPFC during the first postnatal month, corresponding to known critical periods for synapse and neuron formation in mouse sensory neocortex. Our data demonstrate similar maturation profiles of dendritic morphology and intrinsic properties of pyramidal neurons in both deep and superficial layers. In contrast, the balance of synaptic excitation and inhibition differs in a layer-specific pattern from one to four postnatal weeks of age. Our characterisation of the early development and maturation of pyramidal neurons in mouse mPFC not only demonstrates a comparable time course of postnatal maturation to that in other neocortical circuits, but also implies that consideration of layer- and time-specific changes in pyramidal neurons may be relevant for studies in mouse models of neuropsychiatric and neurodevelopmental disorders.