bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanopriming With Zinc-Molybdenum in Jalapeño Pepper on Imbibition, Germination and Early Growth
Authors: Ochoa-Chaparro Erick Humberto , Ramírez-Estrada Carlos Abel , Anchondo-Paez Julio César , Sánchez Esteban , Pérez-Alvarez Sandra , Castruita-Esparza Luis Ubaldo , Muñoz-Márquez Ezequiel , Chávez-Mendoza Celia , Patiño-Cruz Juan José , Franco-Lagos Cristina Larissa
Published: June 2024

The jalapeño pepper is a vegetable of great economic importance worldwide. However, low germination efficiency, weak seedlings, and a high mortality rate during transplant compromise the viability and sustainability of the crop. An innovative solution is the nanopriming tech-nique, an emerging and novel technology, which involves the imbibition of seeds for a specific period using mineral nanoparticles. The addition of micronutrients such as Zinc and Molyb-denum has been used in seed germination and early seedling development due to their crucial roles. The aim of this study was to evaluate the effectiveness of using Zinc-Molybdenum nano-priming in Jalapeño Pepper on germination and early growth. The results showed that applying nanopriming 124-10 mg L−1 of Zinc-Molybdenum promotes effectiveness on the imbibition and germination of jalapeño pepper seeds, resulting in heavier seeds with better initial absorption. This method not only improves germination rates and seedling vigor but also points towards more sustainable and efficient agriculture. Building on these findings, the Zinc-Molybdenum nanopriming method could potentially transform jalapeño pepper cultivation by enhancing seed quality and resilience. This could lead to more robust crop yields and reduce the need for chemical inputs such as fertilizers and pesticides, thus lowering production costs and environ-mental impact.
The Role of Traditional Ecological Knowledge in Environmental Stewardship: Beyond Poverty and Necessity
Authors: Nepal Tej Kumar
Published: June 2024

The persistence of Traditional Ecological Knowledge (TEK) among Indigenous and local communities is often associated with socio-economic constraints, poverty, and lack of choices. Such a perspective argues against underpinning profound environmental consciousness and sustainable practices that underlie TEK. The paper challenges reductionism—viewing TEK solely as a creation of necessity—and tries to argue that it entails a sophisticated understanding of ecological balance and conservation ethics. Through various examples, the paper exemplifies how TEK contributes to environmental sustainability for biodiversity conservation, management and use of natural resources, and the enhancement of resilience to climatic change—the same elements crucial for culture, tradition, and community living.
Treatment of Acute and Long-COVID, Diabetes, Myocardial Infarction, and Alzheimer’s Disease: The Potential Role of a Novel Nano-Compound – the Transdermal Glutathione-Cyclodextrin Complex
Authors: Yutani Ray , Venketaraman Vishwanath , Sheren Nisar
Published: June 2024

Oxidative stress (OS) occurs from excessive reactive oxygen species or a deficiency of antioxidants – primarily endogenous glutathione (GSH). There are many illnesses, from acute and post-COVID-19, diabetes, myocardial infarction, to Alzheimer’s disease, that are associated with OS. These dissimilar illnesses are in order, a viral infection, a metabolic disorder, an ischemic event, and a neurodegenerative disorder. OS may be an early initiator or a significant promotor of their progressive pathophysiologic processes. Consequently, addressing initial OS-related pathology may avoid subsequent severe and irreversible complications. Early intervention would modulate multiple factors, including cytokine stimulation, complement dysregulation, immuno-thrombosis, fibrosis, and autoimmunity. Past clinical studies that addressed OS have had equivocal results. It may be due to the use of ineffective antioxidants, an untimely delay in their use, or an inefficient delivery system. Experimental studies have used antioxidants that are not available for clinical trials. Although GSH can significantly reduce OS, its exogenous use is hampered by the lack of an effective delivery system. By incorporating GSH into cyclodextrin (CD) through nanotechnology, there is recent evidence that exogenous GSH can be delivered more effectively to prevent or mitigate injury from OS [1]. Future studies using the GSH/cyclodextrin (GC) complex will be needed to confirm its effectiveness and, hopefully, offer a path to treat many sub-optimally managed or currently untreatable illnesses.
Effects of Caffeine on Blood Platelets and the Cardiovascular System through Adenosine Receptors
Authors: Marcinek Kinga , Luzak Boguslawa , Rozalski Marcin
Published: June 2024

Caffeine is the most popular and widely-consumed behaviourally-active substance in the world. This review focuses on the influence of caffeine on the cardiovascular system, with a special focus on blood platelets. For many years, caffeine was thought to have a negative effect on the cardiovascular system mainly due to increasing blood pressure. However, more recent data suggests that habitual caffeine consumption may reduce the risk of cardiovascular disease and hypertension. This could be a significant finding as cardiovascular disease is the leading cause of death worldwide. Caffeine is known to inhibit A1 adenosine receptors, through which it is believed to modulate inter alia coronary blood flow, total peripheral resistance, diuresis and heart rate. Although few publications have reported the effects of caffeine on platelet function, it seems reasonable to conclude that caffeine has antiplatelet activity. Platelet activation is known to play a crucial role in the development of arterial thrombotic diseases such as coronary heart disease and stroke, and hence there is a need to develop novel platelet inhibitors. One promising strategy to develop effective antiplatelet therapy involves targeting multiple pathways of platelet activation. Therefore, this review also examines the concept of dual antiplatelet therapy and the potential benefits associated with the therapeutic use of combined P2Y12 antagonists and adenosine receptor agonists in cardioprotection.
Potential Transcriptional Enhancers in Coronaviruses: From Infectious Bronchitis Virus to SARS-CoV-2
Authors: Patarca Roberto , Haseltine William A.
Published: June 2024

Coronaviruses constitute a global threat to human and animal health. It is essential to investigate the long-distance RNA-RNA interactions that approximate remote regulatory elements in strategies, including genome circularization, discontinuous transcription, and transcriptional enhancers, aimed at rapid replication of their large genomes, pathogenicity, and immune evasion. Based on the primary sequences and modeled RNA-RNA interactions of two experimentally de-fined coronaviral enhancers, we detected via in silico primary and secondary structural analysis potential enhancers in various coronaviruses, from the phylogenetically ancient avian IBV to the recently emerged SARS-CoV-2. These potential enhancers possess a core duplex-forming region that could transition between closed and open states, as molecular switches directed by viral or host factors. The open state would permit the enhancer to pair with remote sequences in the viral genome and modulate the expression of crucial genes involved in viral replication and host immune evasion. Consistently, variations in the predicted IBV enhancer region or its distant targets coincide with cases of viral attenuation possibly driven by decreased expression of the ORF3a immune evasion protein. The annotated enhancer sequences could inform structural prediction tools and antiviral interventions if validated experimentally.
Revitalizing Heritage: A Digital Approach to Preserve and Document Historical Structures
Authors: Muralidhar Suhas , Prabhu Prithvi N , B A Neethu Urs , Bhardwaj Ashutosh
Published: June 2024

This study explores the potential of digital technologies for preserving cultural heritage through the case study of the Raya Gopura, an incomplete monument in Melukote, India. Employing a combination of photogrammetry (terrestrial and drone-based) and terrestrial laser scanning, the research team captured highly detailed 3D models of the structure. This non-destructive approach offers a comprehensive digital record for future research and preservation. Furthermore, consultations with experts yielded two possible purposes for the Raya Gopura: an entrance to a planned fort or a gateway to a temple. These insights inform a conjectural architectural drawing of the potentially completed monument. The 3D models hold significant potential for various applications, including tourism, education, and architectural research, with the potential for immersive experiences through VR and AR technologies. In conclusion, this study demonstrates the effectiveness of digital tools in heritage preservation, not only safeguarding the Raya Gopura but also offering valuable insights for future research and public engagement.
Soil Microbial Communities and Wine Terroir: Research Gaps and Data Needs
Authors: Franco Gabriela Crystal , Leiva Jasmine , Nand Sanjiev , Lee Danica Marvi , Hajkowski Michael , Dick Katherine , Withers Brennan Nuque , Soto LuzMaria , Mingoa Benjamin-Rafael Noel , Acholonu Michael , Hutchins Amari , Neely Lucy , Anand Archana
Published: June 2024

Microbes found in soil can have a significant impact on the taste and quality of wine, also referred to as wine terroir. To date, wine terroir has been thought to be associated with physical and chemical characteristics of the soil. However, there is a fragmented understanding of the contribution of vineyard soil microbes to wine terroir. Additionally, vineyards can play an important role in carbon sequestration, since the promotion of healthy soil and microbial communities directly impact greenhouse gas emissions to the atmosphere. We review 24 studies that explore the role of soil microbial communities in vineyards and their influence on grapevine health, grape composition, and wine quality. Studies spanning 2015 to 2018 laid a foundation by exploring soil microbial biogeography in vineyards, vineyard management effects, and the reservoir function of soil microbes for grape-associated microbiota. On the other hand, studies spanning 2019 to 2023 appear to have a more specific and targeted approach, delving into the relationships between soil microbes and grape metabolites, the microbial distribution at different soil depths, and microbial influences on wine flavor and composition. Next, we identify research gaps and make recommendations for future work. Specifically, most of the studies utilize targeted sequencing (16S, 26S, ITS) which only reveals community composition. Utilizing high-throughput omics approaches such as shotgun sequencing (to infer function) and transcriptomics (for actual function) is vital to determine the specific mechanisms by which soil microbes influence grape chemistry. Going forward, understanding long-term effects of vineyard management practices and climate change on soil microbiology, grapevine trunk diseases, and the role of bacteriophages in vineyard soil and wine making would be a fruitful investigation. Overall, the studies presented shed light on the importance of soil microbiomes and their interactions with grapevines in shaping wine production. However, there are still many aspects of this complex ecosystem that require further exploration and understanding to support sustainable viticulture and enhance wine quality.
Cryptocurrency Price Prediction Algorithms: A Survey and Future Directions
Authors: John David L , Binnewies Sebastian , Stantic Bela
Published: June 2024

In recent years, cryptocurrencies have received substantial attention from investors, researchers and the media due to their volatile behaviour and potential for high returns. This interest has led to an expanding body of research aimed at predicting cryptocurrency prices, which are notably influenced by a wide array of technical, sentimental, and legal factors. This paper reviews scholarly content from 2014 to 2024, employing a systematic approach to explore advanced quantitative methods for cryptocurrency price prediction. It encompasses a broad spectrum of predictive models,
from early statistical analyses to sophisticated machine and deep learning algorithms. Notably,
this review identifies and discusses the integration of emerging technologies such as Transformers
and hybrid deep learning models, which offer new avenues for enhancing prediction accuracy and
practical applicability in real-world scenarios. By thoroughly investigating various methodologies
and parameters influencing cryptocurrency price predictions, including market sentiment, technical
indicators, and blockchain features, this review highlights the field’s complexity and rapid evolution.
The analysis identifies significant research gaps and under-explored areas, providing a foundational
guideline for future studies. These guidelines aim to connect theoretical advancements with practical,
profit-driven applications in cryptocurrency trading, ensuring that future research is both innovative
and applicable.
Relationship between Dynamic Balance and Physical Characteristics of Elite Lifesaving Athletes
Authors: Ichikawa Shota , Kumai Tsukasa , Akiyama Yui , Okunuki Takumi , Maemichi Toshihiro , Matsumoto Masatomo , Liu Shijian , Yamaguchi Ryusei , Mitsui Hiroyuki , Suzuki Kai , Niki Hisateru
Published: June 2024

Balance is important in lifesaving competitions. We aimed to investigate the relationship between dynamic balance and physical function in elite lifesavers by measuring the foot muscle cross-sectional area, ankle joint muscle strength, toe grasp strength, plantar superficial sensation, and dynamic balance. In this observational study, we measured the foot muscle cross-sectional area, ankle dorsiflexion, plantar flexion, external flexion, isometric muscle strength, toe grasp strength, and superficial foot sensation of 15 adult lifesavers (12 males). The results showed that toe grasp strength and ankle plantar flexion isometric muscle strength are particularly important for the dynamic balance function of elite lifesavers working on sandy surfaces. Sand training improves intrinsic muscle training and dynamic balance function. However, high training intensity may cause a decrease in plantar surface sensation, which needs to be verified with sand training interventions in the future.
VacStent as an Innovative Approach in the Treatment of Anastomotic Insufficiencies and Leakages in the Gastrointestinal Tract – Review and Outlook
Authors: Yohannes Alexander , Knievel Judith , Lange Jonas , Dormann Arno J. , Hügle Ulrich , Eisenberger Claus F. , Heiss Markus M.
Published: June 2024

Anastomotic insufficiencies are severe complications of abdominal surgery, often leading to pro-longed hospitalization, serious tissue inflammation, even sepsis and the need for recurrent sur-gery. Current non-surgical treatments such as self-expanding metal stents (SEMS) and endoscopic vacuum therapy (EVT) have limitations, including stent migration or perforation. This review evaluates the effectiveness of the VacStent GITM, a novel medical device combining SEMS and negative-pressure wound therapy in treating gastrointestinal leaks. Data were gathered from four prospective studies and compared with existing treatments. Studies on the VacStent GITM applica-tion demonstrate technical success and competitive closure rates in upper gastrointestinal leaks, with minimal complications reported. Comparative analyses with SEMS and EVT reveal prom-ising and most importantly equally good outcomes while maintaining the possibility for sus-tained enteral nutrition and reducing stent migration risk. The VacStent GITM presents a promis-ing alternative to current non-surgical treatments. Ongoing research aims to validate its efficacy in lower gastrointestinal leaks and establish its role in leak management comprehensively. Fur-ther investigation is necessary to confirm these findings and optimize treatment protocols. Future usages of the VacStent GITM in colonic anastomotic insufficiencies promise an effective approach and might be able to lower the rates of necessary implementations of a stoma.
Larval Competition between Aedes and Culex Mosquitoes Carries Over to Higher Arboviral Infection during Their Adult Stage
Authors: Vanslembrouck Adwine , Jansen Stephanie , De Witte Jacobus , Janssens Corneel , Vereecken Stien , Helms Michelle , Lange Unchana , Lühken Renke , Schmidt-Chanasit Jonas , Heitmann Anna , Müller Ruth
Published: June 2024

The common house mosquito (Culex pipiens) is a native vector for West Nile virus (WNV). Invasive species like the tiger mosquito (Aedes albopictus) and Asian bush mosquito (Aedes japonicus) are rapidly spreading through Europe, posing a major threat as vectors for dengue, chikungunya (CHIKV), and Japanese Encephalitis virus (JEV). These mosquitoes share a similar ecological niche as larvae, but the carry-over effects of aquatic larval interactions to terrestrial adult stage remain largely unknown and their medical relevance requires further investigation. This study examines the context-dependency of larval interactions among Aedes albopictus, Aedes japonicus and Culex pipiens. The survival, development time, growth, and energetic storage were measured in different European populations within density-response experiments (intraspecific) and replacement experiments (interspecific) at 20°C and 26°C. Overall, Ae. japonicus was the weakest competitor, while competition between Ae. albopictus and Cx. pipiens varied with temperature. Culex pipiens was infected with WNV, Ae. albopictus with CHIKV and Ae. japonicus with JEV. While no JEV infection was observed, mosquitoes experiencing interspecific interactions during their larval stages exhibited higher infection rates and viral RNA titers for CHIKV and WNV. This increased susceptibility for viral infection after larval competition suggests a higher risk of arbovirus transmission in co-occurring populations.
Underreporting of Cases in the COVID-19 Outbreak of Borriana (Spain) During Mass Gathering Events in March 2020: A Cross-Sectional Study.
Authors: Domènech-Montoliy Salvador , Pac-Sa Maria Rosario , Sala-Trull Diego , Del Rio-González Alba , Sanchéz-Urbano Manuel , Satorres-Martinez Paloma , Blasco-Gari Roser , Casanova-Suarez Juan , Gil-Fortuño Maria , López-Diago Laura , Notari-Rodríguez Cristina , Pérez-Olaso Oscar , Romeu-Garcia Maria Angeles , Ruiz-Puig Raquel , Aleixandre-Gorriz Isabel , Domènech-León Carmen , Arnedo-Pena Alberto
Published: June 2024

Knowing the number of cases of an epidemic is the first function of epidemiological surveillance. An important underreporting of cases was observed in many places during the first wave of COVID-19 pandemic. To estimate this underreporting in the COVID-19 outbreak of Borriana (Valencia Community, Spain), during “Falles” mass gathering events in March 2020, a cross-sectional study was performed in June 2020 querying public health register. Logistic regression models were used. From a total of 468 symptomatic COVID-19 cases diagnosed in the outbreak by anti-SARS-CoV-2 serology, 36 cases were reported (7.7%), thus an underreporting of 92.3% (95% Confidence Interval [CI] 89.5%-94.6%), 13 unreported cases for every reported case. Only positive SARS-CoV-2 polymerase chain reaction cases were predominantly reported due to a limited testing capacity and following a national protocol. Significant factors associated with underreporting were no medical assistance for COVID-19 disease, adjusted odds ratio [aOR] 10.83 (95% CI 2.49-47.11), no chronic illness, aOR=2.81 (95% CI 1.28-6.17), middle and lower social classes, aOR=3.12 (95% CI 1.42-6.85), younger age, aOR=0.97 (95% CI 0.94-0.99), shorter duration of illness, aOR=0.98 (95% CI 0.97-0.99). To improve surveillance, studies of representative population samples are necessary to estimate the magnitude of future epidemics, and novel approaches are recommended.
Relationship between Modern ART Regimens and Immunosenescence Markers in Patients with Chronic HIV Infection
Authors: Grozdeva Rusina Stanislavova , Yancheva-Petrova Nina Stoyanova
Published: June 2024

The increased life expectancy of PLHIV (People Living with HIV) and the successful highly com-bined antiretroviral therapy (cART) poses new clinical challenges regarding aging and its co-morbid condition. It is commonly believed that HIV infection "accelerates" aging. Human immunodeficiency virus type 1 (HIV-1) infection is characterised by inflammation and immune activation that persists despite cART and that may contribute to the development of co-morbid conditions. Toxicity associated with cART contributes to persistent immune dysregulation. Therefore, we aimed to compare current cART regimens in the light of premature aging to evaluate residual immune activation and inflammation in virologically suppressed patients. We studied a panel of biomarkers (IFN-γ, IL-1β, IL-12p70, IL-2, IL-4, IL-5, IL-6, IL-13, IL-18, GM-CSF, TNF-α, C-reactive protein, D-dimer, soluble CD14), which could provide a non-invasive and af-fordable approach to monitor HIV-related chronic inflammation. The results of the current study do not provide hard evidence favoring a particular cART regimen, although they show less fa-vorable regimen profile containing protease inhibitor. Our data suggests incomplete reduction of inflammation and immune activation in terms of the effective cART. It is likely that the inter-est in various biomarkers related to immune activation and inflammation as predictors of clini-cal outcomes among PLHIV will increase in the future.
Pre-service Science Teachers’ Conceptions about Creativity at School: A Study in the Hispanic Context
Authors: Rios-Atehortua Leidy Dahiana , Torres-Valois Tarcilo , Solaz-Portoles Joan-Josep , Sanjosé-López Vicente
Published: June 2024

The present study examines the views of prospective science teachers in Colombia on creativity, employing a mixed-method approach that combines qualitative and quantitative techniques. This approach adapted and used an instrument previously developed by Diakidoy and Kanari [1] to explore student teachers' beliefs about creativity. The sample consisted of 152 science education students from two leading Colombian universities in representative cities. The findings align with previous international studies involving both practicing and trainee professionals, although subtle differences, likely due to cultural variations in the university settings, were observed. It emerged that future science teachers predominantly view creativity as an innate ability present in everyone and capable of development. Additionally, the study underscores the role of the classroom environment in fostering creativity, noting that effective creative expression also requires certain level of prior knowledge.
Predicting Recurrent Deficiency and Suboptimal Monitoring of Thiamin Deficiency in Patients with Metabolic and Bariatric Surgery
Authors: Parrott Julie M , Parrott Austen J , Parrott J Scott , Willliams Noel N , Dumon Kristoffel R
Published: June 2024

Introduction: Vitamin B1 (thiamine) deficiency (TD) after metabolic and bariatric surgery (MBS) is often insidious and, if unrecognized, can lead to irreversible damage or death. As TD symptoms are vague and overlap with other disorders, we aim to identify predictors of recurrent TD and failure to collect B1 labs.
Methods: We analyzed a large sample of data from patients with MBS (n=878) to identify potential predictors of TD risk. We modeled recurrent TD and failure to collect B1 labs using classical statistical and machine learning (ML) techniques.
Results: We identified clusters of labs associated with increased risk of recurrent TD: micronutrient deficiencies, abnormal blood indices, malnutrition, and fluctuating electrolyte levels (aIRR range: 1.62-4.68). Additionally, demographic variables associated with lower socioeconomic status were predictive of recurrent TD. ML models predicting characteristics associated with failure to collect B1 labs achieved 75-81% accuracy, indicating that clinicians may fail to match symptoms with the underlying condition.
Conclusion: Our analysis suggests that both clinical and social factors can increase the risk of life-threatening TD episodes in some MBS patients. Identifying these indicators can help with diagnosis and treatment.
Spatio-Temporal Influence of the Distribution of Forensically Relevant Blowflies (Diptera: Calliphoridae) in Gyeongsangnam-Do, South Korea
Authors: Oh Hyeon-seok , Baek In-Seong , Kang Min-Gyu , Park Sang-Hyun
Published: June 2024

The study of blowfly (Diptera: Calliphoridae) biodiversity and distribution is crucial for forensic investigations. Abiotic and biotic factors, such as seasonal and habitat type, have significant impact on blowfly populations. However, only a few forensic entomology studies have been conducted in South Korea, particularly in the Gyeongsangnam-do region. To address this, an extensive year-long survey was conducted to analyze the compositions, habitat preferences, distribution, and seasonal abundance of forensically relevant blowflies in urban and forested habitats of Gyeongsangnam-do, utilizing mouse carcass-baited traps set for 48 h each month. A total of 3,478 adult blowflies were recorded, encompassing six genera and 14 species, with a noted absence of specimens during the winter months. The predominant species was Lucilia porphyrina, accounting for 37.1% of the total sample, followed by Chrysomya pinguis (27.5%), Lucilia sericata (7.6%), and Lucilia illustris (7.1%). The species composition was consistent across all surveyed regions; however, seasonal variation in species diversity was evident, with a peak in spring and a decline in summer. Notably, certain species exhibited clear preferences for either urban (Calliphora calliphoroides and L. sericata) or forested habitats (L. porphyrina and Ch. pinguis). This pioneering study elucidates the diverse blowfly communities in Gyeongsangnam-do, highlighting significant seasonal and habitat-dependent variations. These findings enrich our understanding of blowfly ecology in this region, offering valuable insights for forensic applications and underscoring the necessity for ongoing entomological surveillance and research.
Carbonization of Refuse-Derived Fuel Pellets with Biomass Incorporation to Solid Fuel Production
Authors: Longo Andrei , Pacheco Nuno , Mota-Panizio Roberta , Vilarinho Cândida , Brito Paulo , Gonçalves Margarida
Published: June 2024

In this work, dry and hydrothermal carbonization (DC and HTC) of RDF pellets were conducted to evaluate the physical, chemical, and fuel properties of the produced chars. In the dry carbonization tests, biomass sawdust was incorporated in different proportions on the samples to minimize agglomeration caused by the melting of the plastic fraction. The experiments were carried out in a temperature of 400°C (DC) and 250-300°C (HTC), in a residence time of 30 minutes. The respective chars and hydrochars were characterized according to their mass yield, apparent density, proximate, elemental, and mineral composition, chlorine content, high heating value, thermogravimetric profile, and surface functional groups. The results showed that dry carbonization of RDF pellets with biomass incorporation, followed by a washing step, resulted in the production of chars with improved properties such as higher fixed carbon and HHV (25-26 MJ/kg) and lower ash and chlorine content. Additionally, the HTC experiments demonstrated that hydrochars showed improved properties without the need for biomass addition and washing, however, with no significant difference in the HHV (20-21 MJ/kg). Therefore, DC of RDF pellets with 10% biomass incorporation seems to be a promising option to overcome the constraints of RDF utilization as an alternative fuel.
Citra Sosial Perempuan dalam Antologi Puisi Hadrah Nyai Karya Raedu Basha
Authors: Hikmah Siti Nur Afifatul
Published: June 2024

Citra sosial perempuan merupakan gambaran dalam diri seorang perempuan dalam kehidupan. Hal ini berkaitan dengan perempuan mempunyai peran penting baik dalam keluarga juga dalam kehidupan sosial. Citra seorang wanita terdiri dari semua jenis citra mental, dan perilaku sehari-hari wanita menunjukkan wajah dan kepribadian wanita. Tujuan penelitian ini untuk mengetahui bentuk citra sosial perempuan dalam Antologi Puisi Hadrah Nyai karya Raedu Basha. Penelitian ini menggunakan metode kualitatif dengan jenis deskriptif dengan bahan penelitian yang bersumber dari dokumen-dokumen berupa karya sastra, dimana fakta-fakta dari informasi yang terkandung dalam karya sastra. Data primer berupa kata atau kalimat yang tertulis dan  dapat diamati dalam hal ini adalah antologi puisi Hadrah Nyai karya Raedu Basha. Teknik yang digunakan untuk pengumpulan data dalam penelitian ini yaitu: 1) membaca dengan seksama atologi puisi, 2) memilah sesuai dengan fokus penelitian, dan 3) menyimpulkan data. Temuan analisis yang dideskripsikan adalah yang berhubungan dengan; (1) citra perempuan dalam keluarga dan (2) citra perempuan dalam masyarakat. Realiatas sosial kehidupan perempuan kini menjadi sorotan. Hal ini dikarenakan perempuan mampu berjuang melawan kekerasan, paksaan, dan sebagainya. Sehingga, citraan sosial perempuan menggambarkan kehidupan perempuan baik dalam keluarga dan masyarakat.
Arabic Language Learning in The Merdeka Curriculum From the Perspective of Progressivism Philosophy
Authors: Jannah Mawaddahtul , Anshori Rodli al , Istiadah Istiadah , Huda Miftahul
Published: June 2024

The aim of this study is to discuss how the philosophical stream of progressivism looks at learning Arabic in the context of the Merdeka curriculum of learning. The qualitative method used by the library research approach. This method based on Miles and Huberman's theory which data of this research was taken by observation and documentation and also analyzed by data reduction techniques, data presentation, and conclusion drawings. The results of this study shown that the progressive philosophical approach to learn Arabic in the context of the Merdeka Learning Curriculum is highly relevant and has the potential to improve the quality of learning. Implementation of progressive concepts such as active learning, hands-on experience, and problem-solving has proven to encourage learners to participate more actively and effectively in the learning process. These findings indicate that progressive approaches can make a positive contribution to improving the effectiveness of learning Arabic in the Merdeka Curriculum.
Keywords: Arabic Language Learning, Merdeka Curriculum, Progressivism, Philosophy, Result of Study
Statistical Upscaling of Transport Parameters Considering Heterogeneous Porosity and Facies Distribution: An Application for Warm Solvent Injection Processes Modeling
Authors: Andriianova Elena , Leung Juliana Y.
Published: June 2024

This paper presents a statistical upscaling workflow for warm solvent injection (WSI) processes, a more environmentally friendly alternative to traditional thermal-based heavy oil extraction methods. The complexity of the heat and mass mechanisms involved in WSI makes flow simulation and optimization challenging. A two-step flow-based upscaling workflow is presented for handling static (facies proportions, porosity, and permeability) and dynamic properties (longitudinal and transverse dispersivity). The first step involves quantifying the effect of numerical dispersivity for a homogeneous model, while the second step incorporates the scaleup of uncertainty in heterogeneity. The method is flexible for handling anisotropic dispersivity upscaling for 3D models. Several novel aspects include (1) considering facies distributions (e.g., sand vs. shale layers), (2) extending the method to 3D, and (3) implementing a cloud transform to sample from the conditional probability distributions of longitudinal and transverse dispersivity considering porosity and net-to-gross (NTG) ratio. An ensemble of coarse-scale models is simulated, demonstrating the proposed workflow’s effectiveness in capturing spatial heterogeneity and improving WSI simulation accuracy in heterogeneous reservoirs.
Reliable Equivalent Alkane Carbon Number Determination for Dead and Live Crudes in Microemulsion Systems
Authors: Yoga Hanif F. , Gasimli Nijat R. , Johns Russell T.
Published: June 2024

A successful surfactant flood maximizes oil recovery by achieving ultralow oil/water interfacial tension (IFT) at the optimal salinity (S*). Optimal salinity, among other parameters, is dependent on the equivalent alkane carbon number (EACN) of the oil pseudocomponent. In this paper, we compare common EACN determination methods used for dead crude at ambient pressure and then propose a third more consistent and reliable method that simultaneously fits data from both methods. The first method is based on a linear plot of lnS* and EACN of pure alkanes, where the dead crude EACN is linearly interpolated using the measured lnS* of the crude. The second method determines the crude EACN by iteration until the measured lnS* of the dead crude and all dilution measurements become nearly linear. For live oil, the EACN is based on the common linear EACN mixing rule but corrected for pressure.

The results show that inconsistencies in estimated crude EACN using the common two methods are resolved when regression is made on all data simultaneously and when an unbiased estimate of optimal salinity is made using hydrophilic-lipophilic deviation–net average curvature (HLD-NAC) theory, where the inverse of three-phase solubility is linear with lnS*. No nonlinear behavior, as has been reported in the literature using the same data, is observed when fit this way and using the simple graphical approach. The graphical approach determines the optimal salinity based on the intersection of the linear regressions of inverse oil and water solubility with lnS*. This approach has the advantage that the optimum is unbiased, and its uncertainty is easily estimated. Using a combination of ambient and high-pressure data, we also show that the EACN of the live oil can be estimated using a methane alkane carbon number (ACN) of 1.0, as it should physically be, when the effect of pressure is properly included.
Significant benefits from international cooperation over marine plastic pollution
Authors: de Vries Frans , Beaumont Nicola , Börger Tobias , Clark James , Hanley Nicholas , Johnston Robert , Meginnis Keila , Stapenhurst Christopher
Published: June 2024

Plastic pollution in the world’s oceans threatens marine ecosystems and biodiversity, and ultimately people. The connected nature of the marine environment suggests that coordinated actions by countries sharing an ocean border may provide more effective pollution control than unilateral actions by any one country. However, economic theory and empirical evidence suggest that countries often fail to cooperate, even when joint economic benefits would be higher under cooperation. Here we present a modelling framework for determining the potential economic benefits of cooperative marine plastic pollution (MPP) management. The framework integrates an estimated plastic transfer matrix with game theory to derive the potential economic benefits of international cooperation for 16 countries bordering the North Atlantic Ocean. A fully cooperative outcome leads to a substantial reduction in MPP, resulting in significant aggregate net economic benefits. Similar findings apply under alternative scenarios and considering modelling uncertainties.
A Recommendation Method Based on Fusion of Graph Neural Network Single-Layer Mixing Negative Samples
Authors: Cai Biao , Zhou Keyi , Cheng Jing , Tang Xiaochuan , Hu Yanmei , Liu Mingzhe , Miao Qiang
Published: June 2024

In deep neural network recommendation models, a common training method is to provide both positive and negative examples to the model to construct the loss function, in order that the model can better learn the useful information in the data because of the increased distinction between positive and negative examples. Due to their focus on strong negative examples, traditional negative sampling methods tend to select false negative samples, which leads to overfitting, reduces the generalization ability of the model, and brings considerable extra computational overhead. For this study, we designed a reliable negative sample fusion generation method named Single-mix. This method reconsiders message propagation mechanisms of node information in graph neural networks (GNNs) and negative sample embedding and fusion during node information aggregation. Single-mix associates information compression and flattening with generalization to reduce redundant information and computational overhead while constructing negative samples effectively. We also propose the number of mixed layers for single-layer enhancement by exploring the structural characteristics of the dataset. Although Single-mix introduces simpler information compression than other negative sampling methods based on GNNs, it achieves superior experimental results on several general experimental datasets.
Stress triggers gut dysbiosis via CRF-CRHR1-mitochondria pathway
Authors: Duan Liping
Published: June 2024

Psychological stress can lead to gut dysbiosis, yet the precise mechanisms underlying the transfer of stress signals from the brain to the gut remain elusive. Here we describe a new pathway that conveys stress from brain to gut and trigger dysbiosis. Acute stress activates hypothalamic-pituitary-adrenal (HPA) axis and release corticotropin-releasing factor (CRF) to elevate colonocytes’ CRF receptors 1 (CRHR1) expression, which damages mitochondrial ultrastructure and respiration function, as well impairs colon epithelium hypoxia, thereby shifts gut microbiota dominant strains from obligate anaerobes to facultative anaerobes. Blocking CRHR1 or activating mitochondria conferred resilience to stress induced mitochondria damaging and epithelium hypoxia impairing. Furthermore, we corroborated these findings by observing significant changes in serum CRF levels, colonocytes’ mitochondria and gut microbiota in patients with irritable bowel syndrome (IBS). These results suggest that the CRF-CRHR1-mitochondria pathway plays a pivotal role in stress-induced gut dysbiosis that could be therapeutically targeted for stress-induced gastrointestinal diseases.
Investigating deformation and seismic data and their relationships during the ongoing unrest of Campi Flegrei caldera (Italy)
Authors: Bevilacqua Andrea , Neri Augusto , De Martino Prospero , Giudicepietro Flora , Macedonio Giovanni , Ricciolino Patrizia
Published: June 2024

Campi Flegrei is the largest active caldera in Europe and it is home of more than 350,000 people. Since 2005, the caldera shows a slow but progressive inflation of the ground and an intensification of seismic activity. Here we quantify the decadal accelerating trend together with oscillations of various frequencies overlying it and explore the relationships between deformation and seismic activity over the period 2000-11/2023. Results reveal an accelerating parabolic increase of vertical uplift, with maximum acceleration of ca. 0.74 cm/yr2, and a super-exponential increase of number of earthquakes and seismic energy release. Inspection of data gives evidence of a close temporal correlation between rates of deformation and seismicity and of an exponential-type relationship, with an exponent increasing in time, between ground deformation and number of earthquakes. These relationships are consistent with a quasi-elastic behavior of the upper crust of the caldera under an increasing stress and suggest a progressive mechanical weakening of it. Most importantly, they provide evidence of an increasing sensitivity of seismic activity on the caldera inflation and warn on the possibility of significant seismic events in case of continuation, with the same trends and relations, of the bradyseismic crisis in the next years.
Psychological capital and mental health problems among the unemployed in Vietnam: Self- esteem as a moderator
Authors: Dat Nguyen Tan
Published: June 2024

Background
Since the COVID-19 pandemic outbreak, unemployment has become a widespread phenomenon in society, with notable consequences including the emergence of mental health problems. This study examined the influence of psychological capital on mental health issues among unemployed people in Vietnam as well as the moderating role of self-esteem in this relation.
Methods
The study adopted a quantitative, cross-sectional approach with 468 recently unemployed office workers in 2023. The participants ranged from ages 22 to 49 years and worked in different fields including technology, finance, consumer services, and infrastructure services.
Result
The results indicated severe to extremely severe mental health symptoms, with 54.5%, 50.8%, and 38.9% of respondents reporting symptoms of depression, anxiety, and stress, respectively. Our results have shown that psychological capital can significantly predict mental health issues including depression, anxiety, stress, and suicidal ideation. Self-esteem was found to play a moderating role in the relation between psychological capital and stress, depression, and suicidal ideation but not anxiety.
Conclusion
Businesses or government agencies should provide mental health support for unemployed workers. Employees should realize that they must improve their psychological capital and self-esteem to propose mental well-being in the post-COVID-19 period.
Adsorption behavior and quantum chemical analysis of surface functionalized polystyrene nano-plastics on gatifloxacin.
Authors: Yang Jie , Ji Wei , Li yanan , Wu Yaning , Yao Meijing , Wu Weiqin , Jing Kangjian , Zhang Guokai
Published: June 2024

Micro / nano plastics will age and produce a variety of functional groups, but there are few studies on the interaction behavior of surface-functionalized nano-plastics with antibiotics. In this paper, 400 nm polystyrene microspheres (PS), amino modified PS-NH2, carboxyl modified PS-COOH (PSNPs) and gatifloxacin (GAT) were selected as research objects. The adsorption of GAT by PSNPs was comparatively studied by both experimental and theoretical calculations, and the adsorption mechanism of nano-plastics to antibiotics were revealed. The equilibrium adsorption capacity of PSNPs to GAT was PS-NH2 > PS-COOOH > PS, and adsorption capacity of PS-NH2 was the largest, which was 236 mg/g. The adsorption kinetics of GAT showed that adsorption was controlled by both physical and chemical mechanisms, and the intra-particle diffusion and external diffusion jointly controlled the adsorption rate. All of Na+, alginic acid, Cu2+ and Zn2+ inhibited the adsorption, and the inhibition effect of Cu2+ and Zn2+ on PS-NH2 adsorption of GAT was the most significant., which may be related to the inhibition of hydrogen bond formation by chelates formed by amino functional groups and heavy metals. The theoretical calculation results showed that π-π interaction and electrostatic interaction were the main interactions between PS and GAT, and electrostatic interactions, hydrogen bonds and van der Waals forces (vdW) were the main interactions between PS-COOH, PS-NH2 and GAT. The surface electrostatic potential of PS-COOH and PS-NH2 was significantly larger than PS, and the maximum penetration distance of van der Waals was GAT-PS-NH2 (1.20 Å) > GAT-PS-COOH (1.06 Å) > GAT-PS (0.63 Å). The results provided a theoretical basis for the migration and synergistic removal of antibiotics and micro-nano-plastics.
Viscoelastic properties of colorectal liver metastases reflect tumour cell viability
Authors: Skrip Lisa-Marie , Moosburner Simon , Tang Peter , Guo Jing , Görner Steffen , Tzschätzsch Heiko , Brüggemann Kristin , Walter Kilian Alexander , Hosse Clarissa , Fehrenbach Uli , Arnold Alexander , Modest Dominik Paul , Krenzien Felix , Schöning Wenzel , Malinka Thomas , Pratschke Johann , Papke Björn , Käs Josef A. , Sack Ingolf , Sauer Igor M. , Hillebrandt Karl
Published: June 2024

Background
Colorectal cancer is the third most common tumour entity in the world and up to 50% of the patients develop liver metastases (CRLM) within five years. To improve and personalize therapeutic strategies, new diagnostic tools are urgently needed. For instance, biomechanical tumour properties measured by magnetic resonance elastography (MRE) could be implemented as such a diagnostic tool. We postulate that ex vivo MRE combined with histological and radiological evaluation of CRLM could provide biomechanics-based diagnostic markers for cell viability in tumours.
Methods
34 CRLM specimens from patients who had undergone hepatic resection were studied using ex vivo MRE in a frequency range from 500 Hz to 5300 Hz with increments of 400 Hz. Single frequency evaluation of shear wave speed and wave penetration rate as proxies for stiffness and viscosity was performed, along with rheological model fitting based on the spring-pot model and powerlaw exponent α, ranging between 0 (complete solid behaviour) and 1 (complete fluid behaviour). For histological analysis, samples were stained with H&E and categorized according to the degree of regression. Quantitative histologic analysis was performed to analyse nucleus size, aspect ratio, and density. Radiological response was assessed according to RECIST-criteria.
Results
Five samples showed major response to chemotherapy, six samples partial response and 23 samples no response. For higher frequencies (> 2100 Hz), shear wave speed correlated significantly with the degree of regression (p ≤ 0.05) indicating stiffer properties with less viable tumour cells. Correspondingly, rheological analysis of α revealed more elastic-solid tissue properties at low cell viability and major response (α = 0.43 IQR 0.36, 0.47) than at higher cell viability and no response (α = 0.51 IQR 0.48, 0.55; p = 0.03). Quantitative histological analysis showed a decreased nuclear area and density as well as a higher nuclear aspect ratio in patients with major response to treatment compared to patients with no response (all p < 0.05)
Discussion
Our results suggest that MRE could be useful in the characterization of biomechanical property changes associated with cell viability in CRLM. In the future, MRE could be applied in clinical diagnosis to support individually tailored therapy plans for patients with CRLM.
Spatial Heterogeneity of Zooplankton Community in an Eutrophicated Tropical Estuary
Authors: Rosas Rayane , Azevedo-Cutrim Andrea Christina Gomes , Cutrim Marco Valerio Jansen , Cruz Quedyane Silva , Campos Danielle Stephane , Sá Ana Karoline Duarte  dos Santos , Oliveira Ana Virgínia Gomes , Santos Taiza Pimentel
Published: June 2024

The alpha diversity and environmental heterogeneity of zooplankton reflect the level of degradation in a macrotidal estuary on the Brazilian equatorial margin. Using the multimetric index (TRIX), we assessed the trophic state and its association with zooplankton composition, distribution, and environmental variables in a tropical estuary. The results showed that significant seasonal and sectoral environmental differences contributed to biological heterogeneity, with the second sector (SII) exhibiting the greatest impact, leading to decreased alpha diversity compared to that of the first sector (SI). Salinity, pH, SiO23, and NO2− exhibited significant seasonal and sectoral variations (p < 0.05). The community consisted of 74 taxa, with copepods (75.7%), mainly from Oithonidae and Paracalanidae, dominating species number. Overall, the community exhibited medium diversity, low richness, and heterogeneity. Beta diversity, calculated using PERMADISP and Jaccard dissimilarity, reflected environmental heterogeneity with significant seasonal differences and biological variability between rainy and dry periods. Indicator species analysis identified 15 taxa, including copepods such as Euterpina acutifrons and Clytemnestra scutellata. Of these, nine taxa (60%) were indicators for the SI, and six (40%) were indicators for the SII. This study underscores the importance of identifying environmental filters and indicator species to understand estuarine dynamics and assess ecosystem trophic states.