bluuebunny/crossref_metadata_2025 huggingface dataset:
Orthopedic Surgery in the Developing World: Workforce and Operative Volumes in Ghana Compared to Those in the United States
Authors: Brouillette Mark A. , Kaiser Scott P. , Konadu Peter , Kumah‐Ametepey Raphael A. , Aidoo Alfred J. , Coughlin Richard C.
Published: November 2013

Background

Musculoskeletal disease is a growing burden in low‐ and middle‐income countries (LMICs), yet little research exists to describe the problem. The purposes of this study were to characterize orthopedic surgery in an LMIC and compare the findings to those from a developed country.

Methods

The study location was the Komfo Anokye Teaching Hospital (KATH) in Kumasi, Ghana. Orthopedic surgeon, resident, and postgraduate training program numbers were compared to analogous data from a developed nation, the United States. Annual surgical volumes were compared to those at a level I trauma center in the United States, the San Francisco General Hospital (SFGH).

Results

There were 24 surgeons in Ghana compared to 23,956 in the United States. There were 7 orthopedic residents and 1 residency program in Ghana versus 3,371 residents and 155 residencies in the United States. Annual case volume was 2,161 at KATH and 2,132 at SFGH. Trauma accounted for 95 % of operations at KATH compared to 65 % at SFGH. The proportion of surgeries devoted to severe fractures was 29 % at KATH compared to 12 % at SFGH. Infections comprised 15 % of procedures at KATH and 5 % at SFGH.

Conclusions

Annual case volume at a referral hospital in an LMIC is equivalent to that of a level I trauma center in an industrialized country. Total case volume is similar, but the LMIC institution manages a disproportionately large number of trauma cases, severe fractures, and infections. There is a large burden of orthopedic disease in the developing nation, and there are too few providers and training programs to address these conditions.
Dynamic Social Networks in Recovery Homes
Authors: Jason Leonard A. , Light John M. , Stevens Edward B. , Beers Kimberly
Published: November 2013

Acute treatment aftercare in the form of sober living environments—i.e., recovery houses—provide an inexpensive and effective medium‐term treatment alternative for many with substance use disorders. Limited evidence suggests that house‐situated social relationships and associated social support are critical determinants of how successful these residential experiences are for their members, but little is known about the mechanisms underlying these relationships. This study explored the feasibility of using dynamic social network modeling to understand house‐situated longitudinal associations among individual Alcoholics Anonymous related recovery behaviors, length of residence, dyadic interpersonal trust, and dyadic confidant relationship formation processes. Trust and confidant relationships were measured 3 months apart in U.S. urban‐area recovery houses, all of which were part of a network of substance use recovery homes. A stochastic actor‐based model was successfully estimated from this data set. Results suggest that confidant relationships are predicted by trust, while trust is affected by recovery behaviors and length of residence. Conceptualizing recovery houses as a set of independent, evolving social networks that can be modeled jointly appears to be a promising direction for research.
Looking Back and Moving Forward: An Historical Perspective from Laboratory Genetic Counselors
Authors: Zetzsche Lindsay H. , Kotzer Katrina E. , Wain Karen E.
Published: November 2013

Despite a consistent increase in genetic counselors who report working in laboratory positions, there is a relative dearth of literature on laboratory genetic counseling. Semi‐structured interviews were completed with nine laboratory genetic counselors to document how positions were created and have changed with time. Interview transcriptions were analyzed for emerging themes. Several common themes were identified, including that early positions were often part‐time, laboratory‐initiated and had a lack of job definition. Laboratory genetic counselors commented on their evolving roles and responsibilities, with their positions becoming more technical and specialized over time and many taking on managerial and supervisory roles. All genetic counselors surveyed reported using core genetic counseling skills in their positions. The expansion of diagnostic testing and quickly evolving technology were common themes in regards to the future of laboratory genetic counselors, and participants commented on laboratory genetic counselors having expanding roles with data management, result interpretation and reporting, and guidance of other healthcare providers. Other comments included the impact of competition among laboratories and how training programs can better prepare genetic counseling students for a career in the laboratory setting. This study describes the emergence, and subsequent evolution, of laboratory genetic counseling positions as a significant subspecialty of genetic counseling.
Up-regulation of FoxN4 Expression in Adult Spinal Cord After Injury
Authors: Chen Xiangdong , Yao Yu , Guan Junjie , Chen Xiaoqing , Zhang Feng
Published: November 2013

FoxN4 (forkhead box N4), which is a transcription factor involved in developing spinal cord and spinal neurogenesis, implied important roles in the central nervous system (CNS). However, its expression and function in the adult CNS lesion are still unclear. In this study, we established a spinal cord injury (SCI) model in adult rats and investigated the expression of FoxN4 in the spinal cord. Western blot analysis revealed that FoxN4 was present in normal spinal cord. It gradually increased, peaked at day 3 after SCI, and then decreased during the following days. Immunohistochemistry further confirmed that FoxN4 was expressed at low levels in gray and white matters in normal condition and increased after SCI. Double immunofluorescence staining showed that FoxN4 is located on neurons and astrocytes, and FoxN4 expression was increased progressively in reactive astrocytes within the vicinity of the lesion, predominately in the white matter. In addition, almost all FoxN4-positive cells also expressed nestin or PCNA. Our data suggested that FoxN4 might play important roles in CNS pathophysiology after SCI.
Sacred and Useful Pleasures: The Temperance Tea Party and the Creation of a Sober Consumer Culture in Early Industrial Britain
Authors: Rappaport Erika
Published: November 2013

This essay argues that the strict branch of the temperance movement helped create and spread an idea of a sober consumer culture in early Victorian Britain. It specifically examines the material and gustatory, political, and religious culture of the mass temperance tea parties that emerged in the 1830s and the 1840s. Supported by middle- and working-class followers, evangelicals, and liberals, the strict branch of the temperance movement insisted that the consumption of tea, sugar, and wheat-based baked goods in a heterosocial setting would demonstrate the rewards of a religious and sober life. Mass tea parties disciplined consumers through satisfying the body and encouraging pleasurable cross-class and mixed-gender interactions. Temperance advocates hoped that the behaviors and values inculcated at the tea table would radiate to the home, the factory, and the marketplace. The temperance movement thus contributed to the notion that drinking tea produced well-behaved and energetic workers, as well as rational consumers.
“We Don't Want Any German Sausages Here!” Food, Fear, and the German Nation in Victorian and Edwardian Britain
Authors: Waddington Keir
Published: November 2013

This essay brings together aspects of the history of science, food, and culture, and applies them to the study of Anglo-German relations and perceptions by examining how between 1850 and 1914 the German sausage was used as a metaphor for the German nation. The essay shows how the concerns that became attached to German sausages not only provide a way of understanding Britain's interaction with Germany but also reveal further dimensions to popular anti-German sentiment. Alarm about what went into German sausages formed part of a growing strand of popular opposition to Germany, which drew on increasing insecurity about Britain's position on the world stage and the perceived economic threat that Germany and German immigrants presented. Such sentiment was translated into how Germans were caricatured and onto material objects—in this case, the “deadly mysteries” that were feared to go into German sausages. Cultural and gastronomic stereotypes overlapped in a discourse that linked Germany and Germans to their national diet and aggressive nature, as well as associated German sausages with fears about diseased meat, adulteration, and the risks that eating them entailed. The result was that the German sausage was used as a staple for satirical comic representations of Germany, as representative of dishonesty in food production, and as a xenophobic slur. Around the German sausage, anti-German sentiment and questions of food safety merged and became mutually reinforcing.
Assessment of tissue distribution and concentration of β-cryptoxanthin in response to varying amounts of dietary β-cryptoxanthin in the Mongolian gerbil
Authors: La Frano Michael R. , Zhu Chenghao , Burri Betty J.
Published: November 2013

There is a general lack of knowledge regarding the absorption and tissue storage of the provitamin A carotenoid β-cryptoxanthin. The present study investigated the whole-body tissue distribution of β-cryptoxanthin in an appropriate small animal model, the Mongolian gerbil (Meriones unguiculatus), for human provitamin A carotenoid metabolism. After 5 d of carotenoid depletion, five gerbils were euthanised for baseline measurements. The remaining gerbils were placed in three weight-matched treatment groups (n 8). All the groups received 20 μg/d of β-cryptoxanthin from tangerine concentrate, while the second and third groups received an additional 20 and 40 μg/d of pure β-cryptoxanthin (CX40 and CX60), respectively, for 21 d. During the last 2 d of the study, urine and faecal samples of two gerbils from each treatment group were collected. β-Cryptoxanthin was detected in the whole blood, and in twelve of the fourteen tissues analysed. Most tissues resembled the liver, in which the concentrations of β-cryptoxanthin were significantly higher in the CX60 (17·8 (sem 0·7) μg/organ; P= 0·004) and CX40 (16·2 (sem 0·9) μg/organ; P= 0·006) groups than in the CX20 group (13·3 (sem 0·4) μg/organ). However, in intestinal tissues, the concentrations of β-cryptoxanthin increased only in the CX60 group. Despite elevated vitamin A concentrations in tissues at baseline due to pre-study diets containing high levels of vitamin A, β-cryptoxanthin maintained those vitamin A stores. These results indicate that β-cryptoxanthin is stored in many tissues, potentially suggesting that its functions are widespread.
Maternal intake of vitamins A, E and K in pregnancy and child allergic disease: a longitudinal study from the Danish National Birth Cohort
Authors: Maslova Ekaterina , Hansen Susanne , Strøm Marin , Halldorsson Thorhallur I. , Olsen Sjurdur F.
Published: November 2013

Fat-soluble vitamins A, E and K have been shown to play roles in immunity and inflammation, but studies on child allergic disease have been few and inconsistent. The aim of the present study was to examine the relationship between maternal intake of vitamins A, E and K in mid-pregnancy and child asthma and allergic rhinitis. We used data on 44 594 mother–child pairs from the Danish National Birth Cohort. Maternal intake of fat-soluble vitamins was calculated based on the information from a validated FFQ completed in mid-pregnancy. At 18 months, interviews with the mothers were conducted to evaluate doctor-diagnosed child asthma. At age 7 years, we assessed child asthma and allergic rhinitis using questions from the International Study of Asthma and Allergies in Childhood questionnaire and by national registries on hospital contacts and medication use. Current asthma was defined as asthma diagnosis and wheeze in the past 12 months by maternal report. We calculated multivariable risk ratios and 95 % CI by comparing the highestv. lowest quintile (Q) of maternal vitamin A, E and K intake in relation to child allergic disease outcomes. Maternal total vitamin K intake was directly associated with ever admitted asthma (Q5v. Q1: 1·23, 95 % CI 1·01, 1·50) and current asthma at 7 years (Q5v. Q1: 1·30, 95 % CI 0·99, 1·70). Weak inverse associations were present for maternal vitamin A and E intake during pregnancy with child allergic rhinitis. Maternal vitamin K intake during pregnancy may increase the risk of child asthma, and should be explored further on a mechanistic level. Conversely, maternal vitamin A and E intake may protect against child allergic rhinitis.
Parameter identifiability and Extended Multiple Studies Analysis of a compartmental model for human vitamin A kinetics: fixing fractional transfer coefficients for the initial steps in the absorptive process
Authors: Park Hyunjin , Green Michael H.
Published: November 2013

In the existing compartmental models of human vitamin A metabolism, parameters related to the absorption of the isotopic oral dose have not been well identified. We hypothesised that fixing some poorly identified parameters related to vitamin A absorption would improve parameter identifiability and add statistical certainty to such models. In the present study, data for serum vitamin A kinetics in nine subjects given [2H8]retinyl acetate orally and a model with absorption fixed at 75 % were used to test this hypothesis. In addition to absorption efficiency, we fixed two other fractional transfer coefficients: one representing the initial processing of the ingested dose and the other representing the direct secretion of retinol bound to retinol-binding protein (RBP) from enterocytes into the plasma. The Windows version of Simulation, Analysis and Modeling software (WinSAAM) was used to fit serum tracer datav. time for each subject. Then, a population model was generated by WinSAAM's Extended Multiple Studies Analysis. All the parameters had fractional standard deviations < 0·5, and none of the pairs of parameters had a correlation coefficient >0·8 (accepted criteria for well-identified parameters). Similar to the values predicted by the original model, total traced mass for retinol was 1160 (sd468) μmol, and the time for retinol to appear in the plasma bound to RBP was 31·3 (sd4·4) h. In conclusion, we suggest that this approach holds promise for advancing compartmental modelling of vitamin A kinetics in humans when the dose must be administered orally.
Resembling breast milk: influence of polyamine-supplemented formula on neonatal BALB/cOlaHsd mouse microbiota
Authors: Gómez-Gallego Carlos , Collado M. Carmen , Pérez Gaspar , Ilo Toni , Jaakkola Ulla-Marjut , Bernal María J. , Periago María J. , Frias Rafael , Ros Gaspar , Salminen Seppo
Published: November 2013

Infant microbiota is influenced by numerous factors, such as delivery mode, environment, prematurity and diet (breast milk or formula). In addition to its nutritional value, breast milk contains bioactive substances that drive microbial colonisation and support immune system development, which are usually not present in infant formulas. Among these substances, polyamines have been described to be essential for intestinal and immune functions in newborns. However, their effect on the establishment of microbiota remains unclear. Therefore, the aim of the present study was to ascertain whether an infant formula supplemented with polyamines has an impact on microbial colonisation by modifying it to resemble that in breast-fed neonatal BALB/c mice. In a 4 d intervention, a total of sixty pups (14 d old) were randomly assigned to the following groups: (1) breast-fed group; (2) non-enriched infant formula-fed group; (3) three different groups fed an infant formula enriched with increasing concentrations of polyamines (mixture of putrescine, spermidine and spermine), following the proportions found in human milk. Microbial composition in the contents of the oral cavity, stomach and small and large intestines was analysed by quantitative PCR targeted at fourteen bacterial genera and species. Significantly different (P< 0·05) microbial colonisation patterns were observed in the entire gastrointestinal tract of the breast-fed and formula-fed mice. In addition, our findings demonstrate that supplementation of polyamines regulates the amounts of total bacteria,Akkermansia muciniphila,Lactobacillus,Bifidobacterium,Bacteroides–PrevotellaandClostridiumgroups to levels found in the breast-fed group. Such an effect requires further investigation in human infants, as supplementation of an infant formula with polyamines might contribute to healthy gastrointestinal tract development.
Adjuvants to improve aerial control of the citrus mealybug Planococcus citri (Hemiptera: Pseudococcidae) using entomopathogenic nematodes
Authors: van Niekerk S. , Malan A.P.
Published: November 2013

The citrus mealybug, Planococcus citri, is a highly destructive pest of citrus, occurring only in the aerial parts of plants. Humidity will be one of the key factors to consider when using entomopathogenic nematodes (EPN) as biological control agents. Different adjuvants can be added to suspensions of EPNs, to improve control as a foliar application. An aqueous suspension containing Heterorhabditis zealandica and 0.3% Zeba® significantly increased P.citri mortality by 22% at 80% relative humidity (RH) with a temperature cycle starting at 22°C for 14 h and 11°C for 11 h. The same polymer formulation was tested for Steinernema yirgalemense and mortality of P. citri increased by 21% at 60% RH and by 27% at 80% RH. The addition of Nu-Film-P® and Zeba® to H. zealandica suspensions did not significantly retard application run-off on citrus leaves. The combination of Nu-Film-P® and Zeba®, however, was able to significantly retard sedimentation, increasing the average number of nematodes deposited on 2-cm2 leaf discs by 10 nematodes. In an aqueous suspension, nematodes settle rapidly to the bottom, resulting in an uneven distribution of nematodes. Xanthan gum, at a concentration of 0.2%, was highly effective at retarding sedimentation, with 72% of the initial nematode number still in suspension after 1 h. Zeba®, at a concentration of 0.3%, despite not being as effective as Xanthan gum, nevertheless still retarded sedimentation significantly. This is the first report of the potential of Nu-Film-P® and Zeba® to improve EPN performance against P. citri when used above ground in citrus orchards.
Oral squamous cell carcinoma and serum paraoxonase 1
Authors: Metin Z Boy , Aydin S , Unur M , Cakmakoglu B , Toptas B , Hafiz G , İsbir T
Published: November 2013

Background:

Serum paraoxonase 1 is involved in mechanisms that protect cells from oxidative stress damage. This study aimed to investigate the correlation between serum paraoxonase 1 activity and polymorphisms in patients with oral squamous cell carcinoma.

Methods and materials:

Fifty-seven patients with oral squamous cell carcinoma and 59 matched healthy controls participated in the study. Serum paraoxonase 1 activity and polymorphisms in blood samples were compared with results for polymerase chain reaction and restriction fragment length polymorphism tests.

Results:

Mean serum paraoxonase 1 activity levels were lower in patients than controls (mean ± standard deviation, 21.9 ± 5 units/l and 120.4 ± 2 units/l, respectively) (p = 0.001). The serum paraoxonase 1 192 glutamine polymorphism was more common in patients than controls.

Conclusion:

Patients with oral squamous cell carcinoma had significantly lower serum paraoxonase 1 activity levels and a greater prevalence of the serum paraoxonase 1 192 glutamine allele, compared with controls. Serum paraoxonase 1 may play a role in the aetiology of oral squamous cell carcinoma.
Bioturbation behaviour in two Mediterranean polychaetes
Authors: Giangrande Adriana , Licciano Margherita , Fanelli Giovanni
Published: November 2013

To evaluate the potential for sediment reworking of two deposit-feeder polychaetes, daily sediment expelled per single worm has been estimated in laboratory experiments on 20 specimens of Nainerislaevigata and 20 of Notomastus latericeus. Both species showed very low values of daily sediment expelled especially when compared to literature data concerning other polychaetes. In both species reworking response was correlated to the dry weight of the worms and appeared higher in Nainerislaevigata, displaying the largest biomass. This species also revealed a greater mobility in situ than Notomastus latericeus which could be considered more as a tube dweller than a burrower.
Translocation and hand-rearing of the short-tailed albatross Phoebastria albatrus: early indicators of success for species conservation and island restoration
Authors: Deguchi Tomohiro , Suryan Robert M. , Ozaki Kiyoaki , Jacobs Judy F. , Sato Fumio , Nakamura Noboru , Balogh Gregory R.
Published: November 2013

Many endemic species, particularly those on remote islands, have been driven to extinction or near extinction by anthropogenic influences. The short-tailed albatross Phoebastria albatrus once numbered in the millions but was thought to be extinct by the mid 20th century. Albatrosses, of the family Diomedeidae, are among the most threatened birds globally as a result of commercial exploitation, introduced predators, and mortality in commercial fisheries. We applied an experimental approach over 5 years to evaluate the translocation and hand-rearing of albatross chicks by comparing growth, physiological health indices, post-fledging survival, and migration patterns with a control group of naturally reared chicks in the source population. Hand-reared chicks had comparable or superior health and similar rates of immediate post-fledging mortality (15%), with mortality strongly female-biased in both groups. Hand-reared birds had longer post-fledging drift periods before attaining sustained flight (also female-biased) but comparable, albeit somewhat wider ranging, migration patterns to naturally reared chicks during their first 6 months at sea. Recruitment to the translocation site of a breeding pair that included a hand-reared bird occurred within 5 years of the first translocation. Success will ultimately depend on continued recruitment and breeding over the coming decades, given delayed breeding in these long-lived species. The results to date, however, have exceeded initial expectations and can inform potential reintroductions of other long-lived, migratory avian species with strong natal philopatry, and reintroductions of native species to former breeding islands.
‘We ate lots of fish back then’: the forgotten importance of fishing in Gwich'in country
Authors: Wishart Robert P.
Published: November 2013

This article attempts to reconcile the fact that fishing has been and continues to be a large part of the Gwich'in local economy with the fact that fishing has been neglected in both popular and scientific accounts of Gwich'in practice. The article puts forth an explanation for why fishing has been neglected while at the same time documenting the corpus of fishing activities included in the yearly round. It also situates fishing as an important, but largely underestimated, part of the Canadian fur trade and explains how fish came to be used by traders and Gwich'in in a system of advances that benefited both parties. As a so-called secondary activity, fishing is entangled in Gwich'in history and their current way of life, and this article challenges the idea that it can be easily separated from other land based activities.
Globalization, Social Justice Issues, Political and Economic Nationalism in Taiwan: An Explanation of the Limited Resurgence of the DPP during 2008–2012
Authors: Qi Dongtao
Published: November 2013

Taking a broader perspective to explore the relations between Taiwan's globalization, social justice issues and the DPP's political and economic nationalism, this study aims to understand the DPP's resurgence in local elections since 2008, and its defeat in the 2012 presidential election. Increasing capital flight from Taiwan to mainland China has contributed to Taiwan's rising unemployment and income inequality. Less privileged Taiwanese, having stronger nationalist sentiments and concerns about the Taiwanese government's open-door China policy, switched their support from the KMT to the DPP during the DPP administration of 2000–2008. Since 2008, the DPP's better balance between its political and economic nationalism has been instrumental in securing popular support, especially at the local level. Nevertheless, in the 2012 presidential election, the DPP failed to convince the majority of Taiwanese voters that its moderate political nationalism could maintain the significantly improved cross-Strait relations vital for Taiwan's economic revival under the current bleak world economic conditions.
Évaluation de l’aptitude d’une personne âgée atteinte de déficits cognitifs à gérer sa personne et ses biens : Identification des outils disponibles
Authors: Giroux Dominique , Tétreault Sylvie , Langlois Lyse
Published: November 2013

The accelerated aging of the Canadian population is a recognized fact and leads to an increasing number of seniors with cognitive impairments (Curateur public du Québec, 2010a). This has a definite impact on health professionals who have to assess their competency to live independently and manage their finances. This decision, which has important consequences for the person, must be based on an objective and rigorous assessment. The purpose of this paper is to analyse the available tools, both in the scientific literature and in clinical settings, to better document the various components to assess seniors’ competency to live independently and manage their finances. The goal is to help practitioners who work with older people with cognitive impairments to accurately assess their ability to manage themselves and their property. A review of the relevant literature and training available, as well as three group consultations, showed that there is no consensus about the tools used to assess the capacity to take care of oneself and one’s property. Additional studies are thus needed to fill the gap in knowledge about specific tools used to assess competency.
Increased incidence of serotype-1 invasive pneumococcal disease in young female adults in The Netherlands
Authors: VAN MENS S. P. , VAN DEURSEN A. M. M. , MEIJVIS S. C. A. , VLAMINCKX B. J. M. , SANDERS E. A. M. , DE MELKER H. E. , SCHOULS L. M. , VAN DER ENDE A. , DE GREEFF S. C. , RIJKERS G. T.
Published: November 2013

Analysis of the Dutch national invasive pneumococcal disease (IPD) surveillance data by sex reveals an increase in the incidence of serotype-1 disease in young female adults in The Netherlands after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in the national immunization schedule. This has led to an overall increase in IPD in women aged 20–45 years, which was not observed in men of the same age. No other differences in serotype shifts possibly induced by the introduction of PCV7 were observed between the sexes in this age group. Serotype 1 is a naturally fluctuating serotype in Europe and it has been associated with disease in young healthy adults before. It remains uncertain whether or not there is an association between the observed increase in serotype-1 disease in young female adults and the implementation of PCV7 in The Netherlands.
The morpho-syntactic status of ne and its effect on the syntax of imperative sentences
Authors: PÉTERS HUGUES
Published: November 2013

This article argues that there is compelling evidence that Frenchne, even in dialects that still have this particle, is no longer negative, does not determine the scope of negation with respect to other operators, does not have properties of a head (optionality), and therefore cannot be analysed as the head of NEGP in Modern Standard French. Rather,neshould be considered as an affix merged to a Tense projection (TNSP) endowed with sub-label features of polarity. This article argues that this proposal provides a unified solution for the distributional properties ofnein finite and non-finite contexts alike. It especially provides an explanation for the structure of French negative imperatives, which are characterised by the proclisis of argument clitics (ne le prends pas‘don't take it’), crucially linked to properties of Tense, as opposed to their enclisis in positive imperatives (prends-le‘take it’) and in spoken registers whereneis absent (prends-le pas‘don't take it’).
French imperatives, negativene, and non-subject clitics
Authors: ROWLETT PAUL
Published: November 2013

This article focuses on the behaviour of negation and clitics in the context of French imperatives. Standard descriptions contrast positiveFais-le !(with enclisis) with negative(Ne) le fais pas !(with proclisis). I adopt a view of imperatives in terms of a pragmatic irrealis mood feature associated with Rizzi's (1997) exploded CP and defective/impoverished morphology which allows inflection and irrealis mood features to be checked on a single functional head. Thus, positive imperatives can check all their grammatical features before merger of any clitics, which (following Shlonsky, 2004) will therefore be enclitic. The presence of negation, when realised as a grammatical feature on an (overt or null) functional head within the clausal trunk, prevents this from happening because negation intervenes between the relevant inflection and mood features in the universal hierarchy underlying the Rizzi/Cinque exploded CP/IP. Outside cliticisation contexts, the difference has no surface impact:Viens !vs.(Ne) viens pas !In cliticisation contexts, in contrast, there is a surface difference: negative imperatives cannot check all their inflectional features at the point at which clitics are merged, and clitics will not therefore be enclitic. Regionally/stylistically marked forms likeFais-le pas !, in which proclisis and negation co-occur, must be deemed to have a radically different structure, with no negative feature projected within the inflectional domain. Such forms are argued to be a natural (and therefore expected) innovation within Jespersen's cycle of diachronic development.
Formative assessment of oncology trainees' communication with cancer patients about internet information
Authors: Bylund Carma L. , Sperka Miryam , D'Agostino Thomas A.
Published: November 2013

Objective:

Cancer patients and their caregivers often turn to the internet for information and support following a cancer diagnosis. Research shows a need for improvement in doctors' communication with patients about internet information. The purpose of this formative assessment was to evaluate oncology trainees' skills in talking about internet information with cancer patients.

Methods:

Thirty-nine oncology trainees were evaluated in a baseline standardized patient assessment as part of their participation in the Comskil Training Program. As part of the assessment, standardized patients were instructed to raise the topic of internet information they had read. Transcriptions of the video-recorded assessments were coded for patient statements and trainee responses.

Results:

Fifty-six percent of trainees used a probe to get more information before addressing the content of the internet search, while 18% addressed it immediately. Eighteen percent of trainees warned the patient about using the internet, and 8% warned about and also encouraged internet use. Thirteen percent of trainees praised the patient for seeking out information on the internet.

Significance of results:

This formative assessment indicated that the majority of trainees addressed the content of the internet search, while a minority addressed the internet as a tool and praised patients' efforts. Research in this area should examine the effectiveness of educational interventions for trainees to improve discussions about internet information.
Identifying socio-environmental factors that facilitate resilience among Canadian palliative family caregivers: A qualitative case study
Authors: Giesbrecht Melissa , Wolse Faye , Crooks Valorie A. , Stajduhar Kelli
Published: November 2013

Objective:

In Canada, friends and family members are becoming increasingly responsible for providing palliative care in the home. This is resulting in some caregivers experiencing high levels of stress and burden that may ultimately surpass their ability to cope. Recent palliative care research has demonstrated the potential for caregiver resilience within such contexts. This research, however, is primarily focused on exploring individual-level factors that contribute to resilience, minimizing the inherent complexity of this concept, and how it is simultaneously influenced by one's social context. Therefore, our study aims to identify socio-environmental factors that contribute to palliative family caregiver resilience in the Canadian homecare context.

Methods:

Drawing on ethnographic fieldnotes and semistructured interviews with family caregivers, care recipients, and homecare nurses, this secondary analysis employs an intersectionality lens and qualitative case study approach to identify socio-environmental factors that facilitate family caregivers' capacity for resilience. Following a case study methodology, two cases are purposely selected for analysis.

Results:

Findings demonstrate that family caregiver resilience is influenced not only by individual-level factors but also by the social environment, which sets the lived context from which caregiving roles are experienced. Thematic findings of the two case studies revealed six socio-environmental factors that play a role in shaping resilience: access to social networks, education/knowledge/awareness, employment status, housing status, geographic location, and life-course stage.

Significance of Results:

Findings contribute to existing research on caregiver resilience by empirically demonstrating the role of socio-environmental factors in caregiving experiences. Furthermore, utilizing an intersectional approach, these findings build on existing notions that resilience is a multidimensional and complex process influenced by numerous related variables that intersect to create either positive or negative experiences. The implications of the results for optimizing best homecare nursing practice are discussed.
Nrf2 affects the efficiency of mitochondrial fatty acid oxidation
Authors: Ludtmann Marthe H. R. , Angelova Plamena R. , Zhang Ying , Abramov Andrey Y. , Dinkova-Kostova Albena T.
Published: November 2013

Transcription factor Nrf2 (NF-E2 p45-related factor 2) regulates the cellular redox homoeostasis and cytoprotective responses, allowing adaptation and survival under conditions of stress. The significance of Nrf2 in intermediary metabolism is also beginning to be recognized. Thus this transcription factor negatively affects fatty acid synthesis. However, the effect of Nrf2 on fatty acid oxidation is currently unknown. In the present paper, we report that the mitochondrial oxidation of long-chain (palmitic) and short-chain (hexanoic) fatty acids is depressed in the absence of Nrf2 and accelerated when Nrf2 is constitutively active. Addition of fatty acids stimulates respiration in heart and liver mitochondria isolated from wild-type mice. This effect is significantly weaker when Nrf2 is deleted, whereas it is stronger when Nrf2 activity is constitutively high. In the absence of glucose, addition of fatty acids differentially affects the production of ATP in mouse embryonic fibroblasts from wild-type, Nrf2-knockout and Keap1 (Kelch-like ECH-associated protein 1)-knockout mice. In acute tissue slices, the rate of regeneration of FADH2 is reduced when Nrf2 is absent. This metabolic role of Nrf2 on fatty acid oxidation has implications for chronic disease conditions including cancer, metabolic syndrome and neurodegeneration.
Addressing Violence against Women as a Form of Hate Crime: Limitations and Possibilities
Authors: Gill Aisha K. , Mason-Bish Hannah
Published: November 2013

In 1998, the Labour government introduced legislation broadening British sentencing powers in relation to crimes aggravated by the offender's hostility towards the victim's actual or perceived race, religion, sexual orientation or disability. Gender is a notable omission from this list. Through a survey of eighty-eight stakeholders working in the violence against women (VAW) sector, this paper explores both the potential benefits and possible disadvantages of adding a gender-based category concerned with VAW to British hate crime legislation. The majority of participants believed that a hate crime approach would offer significant benefits, especially in terms of the symbolic power of the law to send a message to society that VAW is unacceptable. However, most also recognised that the addition of a VAW category to current legislation would involve major practical and conceptual difficulties, not least those resulting from problematic assumptions about the nature of hate crimes versus VAW, and a general unwillingness on the part of policy-makers to address the socio-cultural inequalities that underpin VAW. Overall, the fact that the majority of participants favoured inclusion, on the basis that the possible symbolic benefits were likely to outweigh the potential practical disadvantages, is significant: it speaks to the power of hate crime legislation to challenge many forms of inequality and discrimination still endemic in British society.
New Millennium's Feminine Subject of Feminism
Authors: Rowntree Margaret R.
Published: November 2013

This paper explores the changing feminine subject of feminism by investigating women's sexual daydreams. Described by Rosi Braidotti following Luce Irigaray as the ‘virtual feminine’, and by Teresa de Lauretis as the ‘space-off, the feminist subject is a mutating configuration embodying that which is not colonised from phallogocentric representations. Following Frigga Haug's work on daydreams, the paper is informed by a study that draws on responses from nineteen women in a university setting to an anonymous online survey that asked them to write a daydream about how they would like to express their sexualities in an ideal world. The data reveal that these women of the new millennium imagine spaces of gender/sexual equity, characterised by a spirit of sexual adventure and ethical and emotionally intimate sex. I argue that these sexual imaginings are more progressive than earlier ones, filling in some of the details omitted from contemporary hegemonic representations of feminine sexuality. Arguably providing a snapshot of the feminist subject in its ongoing historical metamorphosis, the paper considers the meaning of these transformations.
Woman's Reappearance: Rethinking the Archive in Contemporary Art—feminist Perspectives
Authors: Zapperi Giovanna
Published: November 2013

Recent debates in the field of contemporary art have underlined the political importance of creative reworkings of the past, especially for those subjects that have been traditionally marginalised. A feminist perspective has been nevertheless quite absent from such debates. This article addresses feminist uses of archival documents in the visual arts through the analysis of three works produced in the past two decades: The Fae Richard's Photo Archive (1997) by Zoe Leonard and Cheryl Dunye, Some Chance Operations (1998) by Renée Green and Queen of the Artists’ Studios (2004–2007) by Andrea Geyer. These works share an interest for women's histories and representations by composing a series of documents (both factual and fictive) into complex narratives where history and subjectivity intersect.
Combinatorial theory of the semiclassical evaluation of transport moments. I. Equivalence with the random matrix approach
Authors: Berkolaiko G. , Kuipers J.
Published: November 2013

To study electronic transport through chaotic quantum dots, there are two main theoretical approaches. One involves substituting the quantum system with a random scattering matrix and performing appropriate ensemble averaging. The other treats the transport in the semiclassical approximation and studies correlations among sets of classical trajectories. There are established evaluation procedures within the semiclassical evaluation that, for several linear and nonlinear transport moments to which they were applied, have always resulted in the agreement with random matrix predictions. We prove that this agreement is universal: any semiclassical evaluation within the accepted procedures is equivalent to the evaluation within random matrix theory. The equivalence is shown by developing a combinatorial interpretation of the trajectory sets as ribbon graphs (maps) with certain properties and exhibiting systematic cancellations among their contributions. Remaining trajectory sets can be identified with primitive (palindromic) factorisations whose number gives the coefficients in the corresponding expansion of the moments of random matrices. The equivalence is proved for systems with and without time reversal symmetry.
An extended magnetostatic Born-Infeld model with a concave lower order term
Authors: Chen Jun , Pan Xing-Bin
Published: November 2013

This paper concerns an extended Born-Infeld model with a concave lower order term for the magnetostatic case. Three types of boundary value problems are considered: the boundary condition prescribing the tangential component of A, the natural boundary condition, and the boundary condition prescribing the tangential component of \documentclass[12pt]{minimal}\begin{document}$\operatorname{curl}\mathbf {A}$\end{document}curlA. In each case we obtain existence and regularity of solutions for small boundary data.
Temperature effect on the small-to-large crossover lengthscale of hydrophobic hydration
Authors: Djikaev Y. S. , Ruckenstein E.
Published: November 2013

The thermodynamics of hydration is expected to change gradually from entropic for small solutes to enthalpic for large ones. The small-to-large crossover lengthscale of hydrophobic hydration depends on the thermodynamic conditions of the solvent such as temperature, pressure, presence of additives, etc. We attempt to shed some light on the temperature dependence of the crossover lengthscale by using a probabilistic approach to water hydrogen bonding that allows one to obtain an analytic expression for the number of bonds per water molecule as a function of both its distance to a solute and solute radius. Incorporating that approach into the density functional theory, one can examine the solute size effects on its hydration over the entire small-to-large lengthscale range at a series of different temperatures. Knowing the dependence of the hydration free energy on the temperature and solute size, one can also obtain its enthalpic and entropic contributions as functions of both temperature and solute size. These functions can provide some interesting insight into the temperature dependence of the crossover lengthscale of hydrophobic hydration. The model was applied to the hydration of spherical particles of various radii in water in the temperature range from T = 293.15 K to T = 333.15 K. The model predictions for the temperature dependence of the hydration free energy of small hydrophobes are consistent with the experimental and simulational data on the hydration of simple molecular solutes. Three alternative definitions for the small-to-large crossover length-scale of hydrophobic hydration are proposed, and their temperature dependence is obtained. Depending on the definition and temperature, the small-to-large crossover in the hydration mechanism is predicted to occur for hydrophobes of radii from one to several nanometers. Independent of its definition, the crossover length-scale is predicted to decrease with increasing temperature.
Enhancement of glucose uptake in skeletal muscle L6 cells and insulin secretion in pancreatic hamster-insulinoma-transfected cells by application of non-thermal plasma jet
Authors: Kumar Naresh , Kaushik Nagendra K. , Park Gyungsoon , Choi Eun H. , Uhm Han S.
Published: November 2013

Type-II diabetes Mellitus is characterized by defects in insulin action on peripheral tissues, such as skeletal muscle, adipose tissue, and liver and pancreatic beta cells. Since the skeletal muscle accounts for approximately 75% of insulin-stimulated glucose-uptake in our body, impaired insulin secretion from defected beta cell plays a major role in the afflicted glucose homoeostasis. It was shown that the intracellular reactive oxygen species and nitric oxide level was increased by non-thermal-plasma treatment in ambient air. These increased intracellular reactive species may enhance glucose uptake and insulin secretion through the activation of intracellular calcium (Ca+) and cAMP production.
Asymptotic expansion of two-electron integrals and its application to Coulomb and exchange lattice sums in metallic, semimetallic, and nonmetallic crystals
Authors: Yamada Tomonori , Brewster Ryan P. , Hirata So
Published: November 2013

A simple, easily implemented, accurate, and efficient approximation of long-range electron-electron-repulsion and electron-nucleus-attraction integrals is proposed. It replaces each product of two atomic-orbital (AO) basis functions of an electron by a point charge centered at the midpoint of the two AO's. The magnitude of the point charge is equal to the overlap integral of the two AO's. Each integral is then rapidly evaluated in the direct algorithm as a Coulomb interaction between two point charges. This scheme is implemented in ab initioHartree–Fock crystalline orbital theory and tested for one-, two-, and three-dimensional solids of metallic, semimetallic, and nonmetallic electronic structures, in which the lattice sums of the direct Coulomb and/or exchange interactions are expected to be slowly convergent. It is shown that this approximation reduces operation and/or memory costs by up to an order of magnitude to achieve converged lattice sums, although the scaling (size dependence) of operation cost is unchanged. An improved criterion for truncating the exchange lattice sum is also proposed.
Orbital dependent Rashba splitting and electron-phonon coupling of 2D Bi phase on Cu(100) surface
Authors: Gargiani Pierluigi , Lisi Simone , Betti Maria Grazia , Ibrahimi Amina Taleb , Bertran François , Le Fèvre Patrick , Chiodo Letizia
Published: November 2013

A monolayer of bismuth deposited on the Cu(100) surface forms a highly ordered c(2×2) reconstructed phase. The low energy single particle excitations of the c(2×2) Bi/Cu(100) present Bi-induced states with a parabolic dispersion in the energy region close to the Fermi level, as observed by angle-resolved photoemission spectroscopy. The electronic state dispersion, the charge density localization, and the spin-orbit coupling have been investigated combining photoemission spectroscopy and density functional theory, unraveling a two-dimensional Bi phase with charge density well localized at the interface. The Bi-induced states present a Rashba splitting, when the charge density is strongly localized in the Bi plane. Furthermore, the temperature dependence of the spectral density close to the Fermi level has been evaluated. Dispersive electronic states offer a large number of decay channels for transitions coupled to phonons and the strength of the electron-phonon coupling for the Bi/Cu(100) system is shown to be stronger than for Bi surfaces and to depend on the electronic state symmetry and localization.