bluuebunny/crossref_metadata_2025 huggingface dataset:
دور المدرسة في تعزيز الإبداع التكنولوجي لدى طلبتها وسبل تطويره
Authors: الصلحات رؤى
Published: October 2024

هدفت الدراسة التعرف إلى دور المدرسة في تعزيز الإبداع التكنولوجي لدى طلبتها وسبل تطويره من وجهة نظر المديرين، والكشف عن وجود فروق بين متوسطات تقديرات أفراد العينة لهذا الدور، واقتراح مجموعة من السبل لتطويره، ولتحقيق أهداف الدراسة استخدمت الباحثة المنهج الوصفي بأسلوبه التحليلي، حيث قامت بتصميم استبانة من مكونة من (26) فقرة موزعة على أربعة مجالات، وتم تطبيق الاستبانة على عينة مكونة من (69) مديراً ومديرة، ومن أهم النتائج التي توصلت إليها الدراسة: تقدير عينة الدراسة لدرجة ممارسة المدرسة لدورها في تعزيز الإبداع التكنولوجي لدى طلبتها من حصل على وزن نسبي (67.41%) أي بدرجة متوسطة، عدم وجود فروق ذات دلالة إحصائية بين متوسطات درجات تقدير العينة لدرجة ممارسة المدرسة لدورها في تعزيز الإبداع التكنولوجي لدى طلبتها تعزى لمتغيرات الدراسة (الجنس، والمديرية)، وجود فروق ذات دلالة إحصائية بين متوسطات درجات تقدير العينة لدرجة ممارسة المدرسة لدورها في تعزيز الإبداع التكنولوجي لدى طلبتها تعزى لمتغيرات الدراسة (عدد الدورات في مجال التكنولوجيا) لصالح 4 دورات فأكثر في مجال المناهج الدراسية، ومجال الطلبة.
كما تم التوصل لمجموعة من سبل تطوير هذا الدور من خلال مقابلات قامت بها الباحثة مع عدد من الخبراء التربويين، تمثلت في التالي: تطوير المناهج بما يتلاءم مع المستحدثات التكنولوجية المتسارعة، دمج التعليم الإلكتروني بالتعليم الوجاهي، تطوير أداء وقدرات المعلمين من خلال الدورات التدريبية الإلزامية وخصوصا مجال التعامل مع التكنولوجيا، العمل على انشاء حاضنة للطلبة المبدعين الذين لديهم ميول تكنولوجية، تزويد الطلبة بأسماء مواقع تقدم دورات خاصة بالتكنولوجيا عبر الانترنت.
وقد أوصت الدراسة بالتالي:

عقد دورات تدريبة للمعلمين تكسبهم من خلالها تقنيات التكنولوجيا المتطورة وتجعلهم قادرين على استثمار طاقات الطلبة المبدعين.
تعزيز دور وزارة التربية والتعليم والمديريات والمشرفين في دعم الإبداع التكنولوجي لدى الطلبة.
تطوير المناهج في ضوء مهارات الإبداع التكنولوجي.
السياحة في ظل جائحة كورونا / استخدام الدراما (عباءة الخبير) في التعليم
Authors: أبو نعمة ميساء
Published: October 2024

Objective: To apply the strategy of mantle of the expert in order to find solutions to the problem of tourism in Palestine in light of the pandemic, as the issue of tourism is one of the topics raised in the eleventh grade curriculum. Thus, technology is used within this project as a tool for communication and as a product that is used in multiple and different contexts. These elements combine to develop the students' English language skills.
How can the pioneers of the tourism industry see the features of the future of travel around the world after this setback? Among the options and ways that can contribute to changing the ways of tourism and finding alternative solutions for regular tourism and travel in light of the pandemic is virtual tourism, which allows individuals to move and enjoy seeing various tourist places using the latest technological technologies and through smart improved reality applications. Through, the eleventh grade students can contribute to thinking to find solutions to the tourism crisis in light of the pandemic by simulating reality and working to intensify their efforts and expertise in contributing to the preparation of the virtual platform for tourism. The students were enrolled as dramatic characters who are experts in the field of electronic content designer and community influencers who carry out tasks requested by the creators of the global platform for virtual tourism. Through this, they learn what is required of them in the English language curriculum, as there are two units in the eleventh grade curriculum that deal with the subject of tourism in an extensive manner.
واقع الإبداع الإداري ومعوقاته لدى مديري المدارس الحكومية والخاصة في محافظة رام الله)
Authors: عليان أيوب , أبو سرحان لبنى
Published: October 2024

الملخص: تهدف الدراسة إلى معرفة واقع الإبداع الإداري ومعوقاته لدى مديري المدارس الحكومية والخاصة في محافظة رام الله من وجهة نظرهم، ,و تم اعتماد المنهج الوصفي التحليلي، وأداة الدراسة،  استبانة مكونة من 30 فقرة موزعة على ثلاثة محاور هي ( المرونة ، الأصالة والتجديد، والحساسية للمشكلات)، وتضمنت الأداة سؤالاً مفتوحاً حول المعيقات للإبداع الإداري، التي تواجه عينة الدراسة التي تم اختيارها بالطريقة العشوائية الطبقية، وتكونت من (76) مدير/ة، أي بنسبة (%38.2) من مجتمع الدراسة، و أظهرت نتائج الدراسة أن واقع الإبداع الإداري جاء بدرجة عالية، وبنسبة مئوية (84.9%). وحصل مجال المرونة على أعلى متوسط حسابي ومقداره (4.33)، يليها مجال الأصالة والتجديد بمتوسط حسابي (4.27)، ثم مجال الحساسية للمشكلات بمتوسط حسابي (4.15). وأظهرت النتائج أن المعيقات بنسبة 27.1% تعود الى المركزية الادارية في اتخاذ القرارات وعدم اعطاء المدير صلاحيات، وهي الأعلى بين المعيقات، ونسبة 24% تتعلق بالأنظمة والقوانين المتبعة في نظام التربية والتعليم، ونسبة 17.7% تعود الى ضعف الامكانيات المادية، ونسبة 8.3% تعود الى ضغط العمل، ونسبة 16.7% تتعلق بعدم قبول بعض المعلمين للأفكار الإبداعية، ونسبة 6.3% مرتبطة بموقع المدرسة والبيئة المحيطة. أبرز التوصيات التي خلص اليها الباحثان ضرورة تطوير الأنظمة والتشريعات التي تمنح الصلاحيات وتتيح مساحة أكبر للإبداع لدى مديري المدارس.
CUMHURİYET DÖNEMİNDE YALOVA’DAKİ BALTACI ÇİFTLİĞİ (1930-1950)
Authors: Şanda Mehmet Nuri
Published: October 2024

Bu araştırmanın konusu Cumhuriyet döneminde Atatürk çiftlikleri arasında yer alan Yalova’daki Baltacı Çiftliği’dir. Araştırma iki ana bölümden oluşmaktadır. Birinci bölümde Yalova’nın konumu ve tarihi hakkında bilgilere yer verilmiştir. İkinci bölümde ise Baltacı Çiftliği’nin konumu, tarihi, kuruluşu, Mustafa Kemal Atatürk’ün çiftliği ziyareti, çiftlik arazisinin topraksız çiftçiye dağıtılması, Baltacı Çiftliği de dâhil tüm Atatürk çiftliklerinin hazineye devri, çiftlikteki tarım ve hayvancılık faaliyetleri, çiftlikte imal edilen süt, yoğurt, tereyağı gibi ürünlerin halka uygun fiyatlarla satılması, çiftliğin Yalova ve İstanbul’daki satış mağazaları, çiftlik arazisi üzerinde yol, iskele, otel, konserve fabrikasının yapılması, çiftliğin teknik ve mali olarak belli aralıklarla denetlenmesi gibi konular üzerinde durulmaktadır. Araştırmada Devlet Arşivleri Başkanlığı Cumhuriyet Arşivi’ndeki belgeler, 1930-1950 yılları arasındaki gazete haberleriyle çok sayıda araştırma ve inceleme eserden istifade edilmiştir. Araştırmada nitel araştırma metodu çerçevesinde tarihsel araştırma yöntemi, doküman-içerik analizi tekniği ve örnekleme yöntemi kullanılmıştır. Literatürde Yalova ve Atatürk çiftlikleri hakkında bazı tez çalışmaları, araştırma inceleme eserler ve makaleler bulunsa da doğrudan Baltacı Çiftliği ve işleyişine yönelik akademik bir çalışma bulunamamıştır. Bu yönüyle araştırmanın literatürde bir boşluğu dolduracağı düşünülmektedir.
A Review on Africa’s Agricultural Farming Systems and Potential for Transition
Authors: Orina Paul Sagwe , M Chepkirui , T Orina , M Olala , FA Oluwole
Published: October 2024

Africa's agriculture is predominantly characterized by smallholder farmers, who make up about 80% of the agricultural sector, often cultivating on less than one acre. Despite the continent's rich mineral resources, there is an urgent need to diversify economic sources of foreign exchange through regional-specific agricultural strategies and a collaborative approach among countries.Although Africa has the potential to be a major food supplier globally, it faces significant challenges, including limited technological adoption and knowledge gaps, compounded by vulnerability to climatic and environmental issues, especially in Northern and Southern Africa.A recent study, employing literature reviews, data mining, and stakeholder engagement, indicates that future agricultural growth must adapt to a globalized context that presents both new opportunities and challenges. Regenerative agriculture practices, such as agro-ecology, sustainable intensification, conservation agriculture, organic farming, circular agriculture, and climate-smart agriculture, hold substantial promise for transforming Africa’s agricultural landscape.However, realizing this potential requires supportive policies. African nations must prioritize demand-driven policies that address production competition, climate challenges, and trade barriers to achieve food security and nutrition through safe food systems.
Book Review ‘Infectious Disease Epidemiology: History, Transmission and Prevention’
Authors: Iqbal Uqbah
Published: October 2024

Written by Victor Trismanjaya Hulu, Salman, Agus Supinganto, Lia Amalia, Khariri, Efendi Sianturi, Nilasari, Nurhayati Siagian, Puji Hastuti&Syamdarniati, given the importance of infectious disease epidemiology in the public health field, it is highly hoped that every health workers can study and understand epidemiology infectious diseases such as epidemiological triad, natural history of disease, transmission and prevention efforts as described in this book. This book was prepared with the aim of providing undergraduate, postgraduate and doctoral students in the field of Public Health Sciences can have new knowledge and basic skills related to infectious disease epidemiology, as well this book can be used as a reference book in preparing final assignments includes thesis and dissertation. The discussion of this book consists of Introduction to Infectious Disease Epidemiology, Measles Epidemiology, Tuberculosis Epidemiology, Polio Epidemiology, Pertussis Epidemiology, Tetanus Epidemiology, Diphtheria Epidemiology, Typoid Epidemiology, Hepatitis Epidemiology and Human Papilloma Virus Epidemiology. Epidemiology is a recent scientific discipline that has developed hand in hand with changes occurring in society and the emergence of new diseases. This evolution has allowed epidemiology to remain a useful tool and relevant in uncovering and understanding diseases and health events. Since its origin over a century ago, there have been many epidemiology definitions has been suggested.
Unpacking the Microfoundations of Sustainability Stakeholder Sensemaking in Global Supply Chains
Authors: Kusnanto Eri , Hadi A Sigit Pramono
Published: October 2024

This qualitative literature review explores stakeholder sensemaking in global supply chains, focusing on the microfoundations of sustainability. Sustainability challenges in supply chains are characterized as complex and multifaceted, involving economic, social, and environmental dimensions that often intersect and conflict. Multinational enterprises (MNEs) play a critical role in addressing these challenges, navigating diverse stakeholder expectations and contextual variations across global operations. The review synthesizes insights from previous studies to highlight the role of sensemaking processes at individual and organizational levels in shaping sustainability strategies within global supply chains. Sensemaking acts as a cognitive and social process through which stakeholders interpret and respond to sustainability issues, influencing organizational responses and strategy formulation. Despite its contributions, the review acknowledges limitations in generalizability and the need for empirical validation in diverse contexts. Future research could benefit from longitudinal studies to capture the evolving nature of stakeholder interactions and sensemaking dynamics in sustainability initiatives.
HIPONATREMIA EM PACIENTES CRÍTICOS: DIAGNÓSTICO E ABORDAGENS TERAPÊUTICAS
Authors: Carlos Henrique Meireles Vieira  , Celio da Costa Ribeiro Pinto  , Marcos Vinicius Borges Martins  , Vitória Maria Almada Bezerra  , Ruhanna Tabatinga Cardoso  , Allison Vieira Cavalcante  , Larissa Rodrigues Vieira  , Gabriela Maria Lavôr Néri Dantas  , Maria Ricarda Costa de Oliveira  , Luis Eduardo Gomes Parente  , Nino Mateus Tavares Testoni  , Kawanny Eler Matt  , Letícia Jacobowskí Ferreira  , Ralline Malala Rodrigues Melo  , Leticia Nunes Costa  , Matheus Oliveira Cardoso  , Isabela Araújo da Silva  , Felipe César Aquino Ramos da Silveira  , Maria Eduarda Gomes Policarpo  , Nicoli Barbieri Gustavo , Júlio Alexandre Gemente Lozano  , Karen Natany Costa de Oliveira  , Nayara Fernandes dos Reis Bovi
Published: October 2024

A hiponatremia é um distúrbio eletrolítico comum em pacientes críticos, caracterizada por baixos níveis séricos de sódio (<135 mmol/L), com prevalência significativa em unidades de terapia intensiva (UTIs). Este artigo revisa os mecanismos fisiopatológicos, diagnóstico e manejo terapêutico da hiponatremia em pacientes críticos. As causas incluem condições subjacentes como insuficiência cardíaca, insuficiência renal, secreção inapropriada de hormônio antidiurético (SIADH) e o uso de diuréticos. O manejo depende da gravidade da hiponatremia e da etiologia específica, destacando o uso de soluções salinas hipertônicas e antagonistas de vasopressina. A correção inadequada dos níveis de sódio pode resultar em complicações graves, como a síndrome de desmielinização osmótica. Estudos recentes sugerem uma abordagem multidisciplinar e personalizada para otimizar os desfechos clínicos, com monitoramento contínuo dos níveis de sódio e ajustes terapêuticos baseados na etiologia e gravidade do distúrbio.
Prevalence of the COVD-19 in Nangarhar Corona Center According to Season in 2020- 2022
Authors: Mulavizada Habibullah , Jabarkhil Abdul Nasir , Rahime Salahuddin , Zafarzai Kamran , Sahak Shukrullah
Published: October 2024

In late 2019, a novel coronavirus emerged and spread quickly from its origin in China across the globe. The CDC-recommended terminology for the virus is SARS-CoV-2 and the illness caused by this virus is called “Coronavirus Disease 2019” or COVID- 19. COVID- 19 was declared a pandemic by the WHO on March 11, 2020. The virus spread to Afghanistan and infected thousands of individuals. The study's aim is to describe the incidence of COVID-19 in the Nangarhar Corona Center, in Afghanistan, according to season between 2020 and 2022. A descriptive retrospective investigation using interview approach and an accidental sampling technique was used to collect data for this study from the inpatient medical records of patients who were identified as having SARS-CoV-2 infection following admission to the Corona Center in Nangarhar province, Afghanistan, between 2020 and 2022. The variables were age, gender of the patient, and season of the year. The data was processed using Microsoft excel and SPSS version 16. In this study, patients who met the inclusion criteria provided 32327 samples. According to age, 12112 female and 20209 male patients were reported.. There were 14337 negative cases and 17990 positive cases out of them. 5271 (29.2%) of the positive instances were found in winter, whereas 4527 (25.1%) were found in fall, 4334 (24.3%) in summer and 3857 (21.4%) in spring. The primary target of the Corona virus is the human respiratory system. The findings of this study indicated that the majority of COVID-19 patients were of 58- 67 years, and the most positive cases 5271 (29.2%) were found in winter, whereas 4527 (25.1%) were found in summer, 4334 (24%) in fall and 3857 (21.4%) in spring. Additionally, our study found that, overall, there was a negative influence of COVID-19 on Afghan population social life. Immediate action is required on the part of the general public in the shape of focused mass psychological support initiatives in order to improve the mental health of those impacted by the COVID-19 problems.
Climate Changes and Distribution of Water Borne Diseases in Eastern, Afghanistan
Authors: Salehi Shah Agha , Rahimee Israrullah , Azami Ahmadgul
Published: October 2024

Subject to a high burden of diarrheal disease, the east provinces of Afghansitan are also suceptable to climate changes. The most devastating consequences are the occurrence of flash floods and aridity. The climate changes trends will exacerbate the health risks associated with deficiencies in water, sanitation and hygiene. This study investigated the distribution of diarrheal disease in the east provinces and how linked with climate variables. Using monthly aggregated new cases of acute diarrhea reported between 2018 and 2023 by Health Management information system department, Ministry of public health of Afghanistan. We found seasonal variation and temperature are positively linked with diarrhea incidence. Initial analysis shows a seasonal trend in diarrhea cases, with peak incidence occurring in summer and reduced incidence during winter months. The recorded diarrhea cases show marked increment in the incidence of acute watery diarrhea in 2023 in eastern region. the incidence of diarrhea cases increased in 2023 (480/1000 population at risk) compared to 2019 (360/1000 population at risk) in eastern region. The impact of flash floods and Aridity as a consequences of climate change in Afghanistan cannot be underestimated. Increasing the incidence of water borne diseases like diarrhea and other infectious diseases outbreaks are important issues that could be assessed. Allowing for policymakers to account for potential impacts of climate change in their public health assessments, and provides a framework that could be extended to similar settings.
Climate Changes and Distribution of Vector Born Communicable Disease in the Eastern Region, Afghanistan.
Authors: Shinwari Abdullah Jan , Sediqi Yama , Himmat Abdul Haq , Sherzad Muhammad Saeed
Published: October 2024

Vector-borne diseases are parasitic, viral, and bacterial diseases continue to contribute significantly to the global burden of disease, and cause epidemics that interrupt health services and cause wider socioeconomic impacts around the world. Aims of this study to describe and measure the epidemiological burden and sessional variation of current Vector- Borne Diseases (VBDs) in the eastern regions of Afghanistan. This was a Retrospective descriptive study in the eastern region of Afghanistan. Data obtained from (Malaria and Leishmaniasis Information System ( MLIS) and Drought Early Warning Decision Support ( DEWS) reports from January 2019 to Dec 2023 of Ministry of Public Health and includes from more than 260 health facilities covering particularly all parts of the east provinces’ territory.  In the result identified four known VBDs in the east four provinces, overall incidences of malaria were 20.28%, Leishmania 1.62%, Dengue 0.054% and Crimean- Congo hemorrhagic Fever (CCHF) 0.0063% with low prevalence’s. Province base Laghman had high incidence (27.82%) then Konar (21.36%) and Nooristan (20.28%) but Nangarhar was relatively in lower incidence (15.8%). Dengue fever firstly coming VBD which two cases were diagnosed in December 2022 and up to 30 December 2023 diagnosed 1526 cases all over district of Nangarhar province. In conclusion, four VBDs incidences have been identified in the eastern region of Afghanistan, and their cases has been clearly increasing in recent years. Their incidences mostly occurring in summer and autumn sessions, Dengue is a newly coming VBD to the Nangarhar province, its spreading is fast, therefore, will distribute more parts of the country rapidly.
President's Message
Authors: Lobo Rommel Crisenio
Published: October 2024

Greetings of Peace and Blessings!
First of all, a big "Congratulations!” to PSAAI! This day, our 50th anniversary, may we all be healthy to celebrate this Golden moment.
In this time of the pandemic, we have come up with five versions of "A Review of Immunomodulators as Therapeutic Interventions for Moderate to Severe COVID-19 Infections," Guidelines for Health Risk Assessments for Adverse Reactions to COVID-19 Vaccines for adult, adolescent, and pediatric vaccinees, all to help our fellow physicians to be guided in the care of our patients.
Our efforts have not gone unnoticed locally but internationally as well. We continue to be an active member society of the World Allergy Organization, Asia Pacific Association of Allergy, Asthma and Clinical Immunology, and Asia Pacific Academy of Pediatric Allergy, Respirology and Immunology. We have come this far because of everyone's concerted efforts and cooperation.
For this, thank you very much. Let us continue to work harmoniously by helping each other to better our current best for a stronger and healthier PSAAI.
God bless us more.
Message
Authors: Salvador-Tayag Felicia Racquel
Published: October 2024

It is with great honor and privilege to lead the PSAAI@50 Golden Anniversary celebration. Looking back, I have always been inspired by my mentors during my fellowship training in Allergy and Immunology in the UP-PGH and the great and accomplished leaders of PSAAI. From 11 inspiring founders, we are now 154 strong, all over the archipelago and abroad!
This is a time to look back, reminisce, reflect, and take pride in the accomplishments of PSAAI in the past 5 decades. Since its foundation in 1972, PSAAI has been recognized in the field of allergy and immunology not only locally but we have made our mark internationally as well through the efforts of our dedicated and passionate leaders and hardworking and committed members. We continue to excel in education, research, and community service. Through the society's activities, we serve not just our patients and colleagues but also the environment through our advocacies.
This is a time to look ahead. This pandemic continues to bring challenges to the society but we rose and excelled to the occasion. PSAAI came to the forefront in the fight to end this pandemic. In this age of misinformation and fake news, PSAAI came up with well-researched, science-based position statements and guidelines in vaccination and treatment of COVID-19. Our members are also giving their time and talent in the national and regional government agencies as advisers and experts in vaccination, allergy, and immunology. These are the society's services to the Filipino people.
This year, we celebrate PSAAI's 50 glorious years, and we will continue to make history in the next 50 years and beyond. This book compiles the achievements and wonderful memories of PSAAI in the past 5 decades.
May this inspire the young and future members to continue the legacy of what our elders started and continue to excel beyond what is expected. We praise and thank God for continuously guiding us in all our endeavors and may He continue to strengthen our camaraderie and lead us to pursue our commitment to excellence and service.
Congratulations, PSAAI! I am proud to be PSAAI!
Neonatal Outcomes of Women with Recurrent Pregnancy Loss from Immunologic Causes in the Philippine General Hospital from 2010-2015
Authors: Chacon Hyacinth Claire , Mondragon Alric , Castor Mary Ann , Recto Marysia Stella , Casis Hao Roxanne , Sumpaico Madeleine
Published: October 2024

Background: Recurrent pregnancy loss (RPL) has been classically defined as three consecutive pregnancy losses, which may be associated with several immunologic and non-immunologic etiologies. There are two immunologic mechanisms, autoimmune or alloimmune, of RPL that have drawn much interest in recent years. The direct effects of these immunologic dysregulations on the clinical outcomes of children born from mothers afflicted with Antiphospholipid Antibody Syndrome (APS) or alloimmune causes still need further investigation.
Objective: To determine the neonatal outcome of infants born from mothers with RPL from immunologic causes at the Philippine General Hospital (PGH) from 2010-2015. Pregnant women with RPL from immunologic causes are classified as high-risk pregnancies. The results of this study hope to guide physicians in close monitoring and early intervention of mothers with RPL and their neonates.
Methodology: This was a retrospective study of neonates born from mothers diagnosed to have immunologic causes of RPL from 2010-2015 at the PGH. All patients born from mothers diagnosed to have an immunologic cause of RPL from 2010-2015 based on the patient database of the section of Allergy and Immunology of the PGH.
Results: The prevalence of neonates born from mothers with RPL from identified immunologic causes and unexplained causes among all infants born at the PGH from 2010 to 2015 is 0.18%. There were 5.1% of the neonates that were classified as Classical APS, 63.8% as Obstetric Morbidity associated with Antiphospholipid
Antibody Syndrome (OMAPS), and 31% had an unexplained cause. There were no cases classified under other immunologic causes. Most neonates under Classical APS were born live, full-term, via cesarean delivery with a mean birth weight of 2206 ± 539.48 grams with APGAR Score (AS) of 9 and 9. The majority of the neonates under OMAPS were born live, full-term, via cesarean delivery with a mean birth weight of 2537 ± 737.46 grams and AS of 9 and 9. Most of the neonates under the unclassified cause of RPL were born live, full-term via cesarean delivery with a mean birth weight of 2228.75 ± 887.05 grams and an AS of 9 and 9.
Conclusion: The majority of these infants born from mothers with RPL from immunologic or unexplained causes had a good birth outcome. Hence, the immunologic cause of RPL has minimal effects on the neonate.
Correlation of Vitamin D Levels with the Severity of Atopic Dermatitis Among Filipino Children Aged 1 Month to 18 Years Old Using the SCORAD Index
Authors: Reyes Roche Dana , Recto Marysia Stella , Castor Mary Anne , Casis Hao Roxanne , Sumpaico Madeleine
Published: October 2024

Objective: To correlate Vitamin D levels with the severity of atopic dermatitis (AD) using the SCORAD index.Methodology: Patients aged 1 month to 18 years seen at the Philippine General Hospital Outpatient Department, diagnosed with AD based on Hanifin and Rajka criteria, were recruited into the study. The extent and severity of AD were assessed using the SCORAD index. Serum concentrations of vitamin D were determined using the Beckman Coulter Radioimmunoassay, California.Results: A total of 53 patients were included in the study. Mild AD was diagnosed in 27 (50.9%) children, moderate in 21 (39.6%), and severe in 5 (9.4%). Vitamin D insufficiency was observed in 39 individuals (73.6%). Of these, 20 (51.3%) had mild AD, 15 (38.5%) had moderate, and 4 (10.3%) had severe AD. Of the 14 individuals (26.4%) with sufficient vitamin D levels, 7 (50.0%) had mild AD, 6 (42.9%) moderate, and 1 (7.1%) severe. There is no significant correlation between serum vitamin D levels and the actual SCORAD index with a p of 0.26.Conclusion: In conclusion, serum vitamin D level has no significant correlation with the severity of AD as measured by the SCORAD index.
Ventilasi Noninvasif pada Obstructive Sleep Apnea dan Obesity Hypoventilation Syndrome
Authors:   Divisi Respirologi dan Penyakit Kritis, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Jakarta, Herikurniawan Herikurniawan
Published: October 2024

Chronic respiratory disease such as obstructive sleep apnea (OSA) and obesity-hypoventilation syndrome (OHS) remain are respiratory sleeping disorder that gradually affect quality of life. Comprehensive treatment such as the use of non-invasive ventilation (NIV) is a method adopted to improve the patient’s quality of life. The correct choice of NIV mode, mask and titration methods will provide optimal therapeutic effects to the patient. This article review lays out an update on the use of non-invasive ventilation as the treatment of OSA and OHS.
Peran Pemeriksaan Penanda Tumor Cairan Pleura dalam Diagnosis Efusi Pleura Maligna Akibat Kanker Paru Primer
Authors:   Divisi Respirologi dan Penyakit Kritis, Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia/Rumah Sakit dr. Cipto Mangunkusumo, Jakarta, M. Rumende Cleopas
Published: October 2024

Introduction. Pleural effusion is a frequently acquired lung disorder and based on the type of cause it is divided into malignant and non-malignant pleural effusion. Cytological examination of pleural fluid to differentiate between malignant and non-malignant pleural effusion shows varying sensitivity. Research regarding the benefits of CEA and Cyfra 21-1 pleural fluid examination to detect malignant pleural effusion due to primary lung cancer in Indonesia is still very limited. The aims of this study is to determine the sensitivity and specificity of CEA and Cyfra 21-1 pleural fluid in diagnosing malignant pleural effusion due to primary lung camcer. Methods. A cross-sectional diagnostic study was conducted on patients with exudative pleural effusion at Dr. Cipto Mangunkusumo National Hospital (RSCM) and Darmais Cancer Hospital between September 2015 and May 2016. Patients underwent examinations for carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (Cyfra 21-1) in their pleural fluid. The ROC curves were generated to determine the optimal cut-off values for CEA and Cyfra 21-1 concentrations in pleural effusion, considering the area under the curve (AUC) obtained. Chi-square tests were performed to assess sensitivity and specificity, as well as to calculate positive predictive value, negative predictive value, and accuracy for each cut-off value for both CEA and Cyfra 21-1. Results. A total of 122 patients with exudative pleural effusion, positive cytology results were obtained in 80 patients. By using the CEA cut-off value of 4.23 ng/ml, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 87.50%, 80.95%, 89.74%, 77.27% and 85.25% with an AUC value of 0.878 (0.814 - 0.942). By using the Cyfra 21-1 cut-off value of 26.9 ng/ml, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 78.75%, 71.43%, 84.00%, 63.82% and 76.23% with an AUC value of 0.817 (0.739 - 0.896). Conclusion. Examination of CEA and Cyfra 21-1 level in pleural fluid can be used to support the diagnose of malignant pleural effusion due to primary lung cancer.
Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway
Authors: Chen Jianwen , Zhao Bao , Dong Hong , Li Tianliang , Cheng Xiang , Gong Wang , Wang Jing , Zhang Junran , Xin Gang , Yu Yanbao , Lei Yu L , Black Jennifer D , Li Zihai , Wen Haitao
Published: October 2024

The O-GlcNAc transferase (OGT) is an essential enzyme that mediates protein O-GlcNAcylation, a unique form of posttranslational modification of many nuclear and cytosolic proteins. Recent studies observed increased OGT and O-GlcNAcylation levels in a broad range of human cancer tissues compared to adjacent normal tissues, indicating a universal effect of OGT in promoting tumorigenesis. Here, we show that OGT is essential for tumor growth in immunocompetent mice by repressing the cyclic GMP-AMP synthase (cGAS)-dependent DNA sensing pathway. We found that deletion of OGT (Ogt−/−) caused a marked reduction in tumor growth in both syngeneic mice tumor models and a genetic mice colorectal cancer (CRC) model induced by mutation of the Apc gene (Apcmin). Pharmacological inhibition or genetic deletion of OGT induced a robust genomic instability (GIN), leading to cGAS-dependent production of the type I interferon (IFN-I) and IFN-stimulated genes (ISGs). As a result, deletion of Cgas or Sting from Ogt−/− cancer cells restored tumor growth, and this correlated with impaired CD8+ T-cell-mediated antitumor immunity. Mechanistically, we found that OGT-dependent cleavage of host cell factor C1 (HCF-1) is required for the avoidance of GIN and IFN-I production in tumors. In summary, our results identify OGT-mediated genomic stability and activate cGAS-STING pathway as an important tumor-cell-intrinsic mechanism to repress antitumor immunity.
Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal
Authors: Wang Xiaoning , Zhao Jinxiang , Xu Jiehuan , Li Bowen , Liu Xia , Xie Gangcai , Duan Xuchu , Liu Dong
Published: October 2024

Artificially sweetened beverages containing noncaloric monosaccharides were suggested as healthier alternatives to sugar-sweetened beverages. Nevertheless, the potential detrimental effects of these noncaloric monosaccharides on blood vessel function remain inadequately understood. We have established a zebrafish model that exhibits significant excessive angiogenesis induced by high glucose, resembling the hyperangiogenic characteristics observed in proliferative diabetic retinopathy (PDR). Utilizing this model, we observed that glucose and noncaloric monosaccharides could induce excessive formation of blood vessels, especially intersegmental vessels (ISVs). The excessively branched vessels were observed to be formed by ectopic activation of quiescent endothelial cells (ECs) into tip cells. Single-cell transcriptomic sequencing analysis of the ECs in the embryos exposed to high glucose revealed an augmented ratio of capillary ECs, proliferating ECs, and a series of upregulated proangiogenic genes. Further analysis and experiments validated that reduced foxo1a mediated the excessive angiogenesis induced by monosaccharides via upregulating the expression of marcksl1a. This study has provided new evidence showing the negative effects of noncaloric monosaccharides on the vascular system and the underlying mechanisms.
A destructive active defense algorithm for deepfake face images
Authors: Yang Yang , Idris Norisma Binti , Liu Chang , Wu Hui , Yu Dingguo
Published: October 2024

The harm caused by deepfake face images is increasing. To proactively defend against this threat, this paper innovatively proposes a destructive active defense algorithm for deepfake face images (DADFI). This algorithm adds slight perturbations to the original face images to generate adversarial samples. These perturbations are imperceptible to the human eye but cause significant distortions in the outputs of mainstream deepfake models. Firstly, the algorithm generates adversarial samples that maintain high visual fidelity and authenticity. Secondly, in a black-box scenario, the adversarial samples are used to attack deepfake models to enhance their offensive capabilities. Finally, destructive attack experiments were conducted on the mainstream face datasets CASIA-FaceV5 and CelebA. The results demonstrate that the proposed DADFI algorithm not only improves the generation speed of adversarial samples but also increases the success rate of active defense. This achievement can effectively reduce the harm caused by deepfake face images.
Changes in the force-time curve during a repeat power ability assessment using loaded countermovement jumps
Authors: Natera Alex O. , Hughes Steven , Chapman Dale W. , Chapman Neil D. , Keogh Justin W.L.
Published: October 2024

Background

Repeat power ability (RPA) assessments traditionally use discrete variables, such as peak power output, to quantify the change in performance across a series of jumps. Rather than using a discrete variable, the analysis of the entire force-time curve may provide additional insight into RPA performance. The aims of this study were to (1) analyse changes in the force-time curve recorded during an RPA assessment using statistical parametric mapping (SPM) and (2) compare the differences in the force-time curve between participants with low and high RPA scores, as quantified by traditional analysis.

Materials and Methods

Eleven well-trained field hockey players performed an RPA assessment consisting of 20 loaded countermovement jumps with a 30% one repetition maximum half squat load (LCMJ20). Mean force-time series data was normalized to 100% of the movement duration and analysed using SPM. Peak power output for each jump was also derived from the force-time data and a percent decrement score calculated for jumps 2 to 19 (RPA%dec). An SPM one-way ANOVA with significance accepted at α = 0.05, was used to identify the change in the force-time curve over three distinct series of jumps across the LCMJ20 (series 1 = jumps 2–5, series 2 = jumps 9–12 and series 3 = jumps 16–19). A secondary analysis, using an independent T-test with significance accepted at p < 0.001, was also used to identify differences in the force-time curve between participants with low and high RPA%dec.

Results

Propulsive forces were significantly lower (p < 0.001) between 74–98% of the movement compared to 0–73% for changes recorded during the LCMJ20. Post hoc analysis identified the greatest differences to occur between jump series 1 and jump series 2 (p < 0.001) at 70–98% of the movement and between jump series 1 and jump series 3 (p < 0.001) at 86–99% of the movement. No significant differences were found between jump series 2 and jump series 3. Significant differences (p < 0.001) in both the braking phase at 44–48% of the jump and the propulsive phase at 74–94% of the jump were identified when participants were classified based on low or high RPA%dec scores (with low scores representing an enhanced ability to maintain peak power output than high scores).

Conclusion

A reduction in force during the late propulsive phase is evident as the LCMJ20 progresses. SPM analysis provides refined insight into where changes in the force-time curve occur during performance of the LCMJ20. Participants with the lower RPA%dec scores displayed both larger braking and propulsive forces across the LCMJ20 assessment.
Landscape-scale monitoring for forest fauna is achievable: a case study using remote sensors, artificial intelligence and robust analytics
Authors: Gonsalves Leroy , Law Brad , Slade Chris
Published: October 2024

Landscape-scale monitoring is used to track changes in the status of fauna populations, including identifying when and where change is occurring over large areas. Yet few programs at this scale exist despite calls for long-term monitoring, especially after the ‘black summer’ fires of 2019/20. Landscape monitoring often sits in the ‘too hard and too expensive basket’. To encourage land managers to maintain existing programs or establish new ones, it is important to demonstrate approaches that can cost-effectively monitor fauna and assess the level of investment required to adequately assess trends. We used passive acoustic and ultrasonic monitoring with artificial intelligence to semi-automate the detection of vocalisations from Koalas, Yellow-bellied Gliders, Powerful Owls and Sooty Owls and echolocation calls from two threatened bat species (Eastern Falsistrelle and Little Bent-wing Bat) as part of a pilot study for forest monitoring at a landscape-scale. Analyses that accounted for imperfect detection were used to: (1) generate detection probability and initial occupancy estimates for selected priority fauna species, and (2) undertake power analyses to inform sampling effort, and duration required to detect a commonly applied trend (30% decline over 10 years). Cost-effectiveness of sampling with remote sensors and traditional methods was also examined. Several thousand detections of priority species were recorded, with the number of detections varying by species and season. This translated to differences in detection probability and occupancy for each species. Detection probability was sensitive to the sampling intensity (number of surveys/sensors) deployed at a given site and this varied between seasons, with >95% probability of detection achieved for most species when multiple subplots were sampled for a 2-week period. Power analyses revealed trade-offs between sampling effort (number of sites) and duration (number of visits) required to detect a trend. Only a modest investment was needed to monitor widespread species that are moderately detectable using remote sensors with artificial intelligence and this investment was 2-11 times lower than monitoring using traditional methods for the priority species examined. For very rare species that are not widespread, localised monitoring and/or targeted research may be more suitable. Nevertheless, landscape-scale monitoring for many forest fauna is achievable using cost-effective remote sampling, artificial intelligence and robust analytics that account for imperfect detection. Now, more than ever, we urge support for and implementation of landscape monitoring for biodiversity.
Development of Ready to Use Pellets from Tamarind (Tamarindus indica L.) Fruit Pulp
Authors: Pandian N. Karpoora Sundara , Prithya S. , Kamaleeswari K. , Kishore S. Ganga
Published: October 2024

Tamarind is a widely grown tree in the Indian subcontinent and the fruit pulp plays a major role in south Indian cuisine for enhancing both traditional and contemporary recipes. The tamarind fruit pulp was primarily dried (48 hours) in a solar dryer to achieve a moisture content of 9% (w.b.), and the five treatments were made by combining dried tamarind pulp with corn flour in the ratios of 1:1, 1.5:1, 2:1, 2.5:1, and 3:1. All treatments were analysed for physicochemical, sensory evaluation, and time required for partial and complete solubility of produced tamarind pellets under varied temperature settings (55℃, 65℃, and 100℃) and with and without stirring. The sensory evaluation results indicate that a 3:1 sample ratio has higher overall acceptance (8.4±0.1316). The pH and acidity of each sample show an inverse relationship. The most accepted sample (3:1) had a higher acidity value of 17.2±0.13127% and a lower pH of 2.74 ±0.13139% compared to other treatments. The time required to dissolve all treatments decreased as the temperature increased throughout the stirring technique. The 3:1 sample took 5.1 and 8.5 minutes to achieve partial and entire solubility at 100℃ with stirring. Tamarind content has a significant impact on tamarind pellet solubility. Ready-to-use tamarind pellets were produced as a result of efficient tamarind utilization. It can be used instantly during the cooking process, saving time on making tamarind paste.
The Impact of Proper Citation on Academic Integrity and Scholarship
Authors: Panjaitan Ani Oranda , Novelyn Silphia , Angreni Frisca
Published: October 2024

Aims: to revisited the importance of citing the sources properly, discusses the noble human values regarding citation and simple example of citation in the context of academic writing
Discussion:  The importance of citations in academic writing offer clear and convincing evidence which build on arguments and facts asserted carefully by authors in their academic writing. Beside of that, a well-organized cited text-section also a conclusive evidence of acknowledges the endeavor and hard work of previous scholars who had struggling published his/her work which is now being quoted. Citations in academic writing are treasure references to all the sources an author has used to support his/her own ideas and then carefully referred to during his/her writing on a manuscript. authors have the obligation to supply references to all the published/unpublished works they reviewed and used. The cited works can include books, research papers, websites, and other internet sources that writers ascribe to using certain citation styles/format. Actually, there are differences in citation styles (APA, MLA, etc.) and their relevance in different academic contexts literally make scholars and readers become more integrated in context. By citing properly, it highlights a true noble human values such as honesty, resilience, hard work, humility, gratitude, credibility, integrity, open-mindedness and obedience. This approach reveals an author’s academic expertise, render rationality to a text and honor intellectual honesty. In other words, citations carry critical significance in academic writing. The challenges or common pitfalls associated with improper citation can be in the form of inappropriate misused of citing, which further slowing actual progress in research and circulating unsupported beliefs. For academic writers, it is essential to understand the grounds for this significance.
Conclusion: Citing the sources properly will help the author, the reader, the editors and the peer reviewer and in the end, the entire scientific community reinforces a responsibility for ensuring that the customs, traditions, and ethical standards that guide the whole process of accountable and reliable academic writing products.
Integrating Automation and Big Data in Lithium-Ion Battery Manufacturing: A Case Study of the Ultium Cells Joint Venture
Authors: Song Joonghyun
Published: October 2024

Aim: To examine the integration of automation and big data in lithium-ion battery manufacturing using Ultium Cells joint venture as case study.
Problem Statement: The havocs attached to the exhausts emission from fossil-fuel based automobiles are major concerns to the whole world. Records indicating lowering of air quality and depletion of the ozone layer have been reported. Furthermore, the quest to save money spent on non-renewable energy has necessitate the call for research studies on advancement of lithium-ion battery manufacturing. Also, the traditional battery manufacturing techniques production capacities cannot meet the demand for electric vehicles. Nonetheless, the consistency and quality control of the battery cell is challenging.
Significance of Study: The use of electric vehicles is prevailing and thus has greatly influenced the need to technological improvement in the production of lithium-ion batteries (LIBs) which are being utilized in electric vehicles. The analysis of big data can provide real-time decision-making and long-term process improvements. This technical review is an eye-opener for researchers on the need to integrate automation and big data in lithium-ion battery manufacturing.
Methodology: Recent literature materials in form of books, journals and relevant published articles in the area of automation and big data in lithium-ion battery manufacturing were consulted.
Discussion: In this technical review, consideration was given to the integration of automation and big data in lithium-ion battery manufacturing using Ultium Cells joint venture as a case study. The types of lithium-ion batteries and their assemblies were discussed. The battery cells contain the cathode, anode and electrolyte and come in three varieties of designs which are pouches, prismatic cans and cylindrical designs. One of the main requirements that enhance the automation of assembly line in Li-ion battery manufacturing is the use of the collected data from the survey as stated by the industry. The concept is made up of 6 modular sectors such that each sector has the capacity of being scaled up and down based on customer requirements. The three major steps involved in data-driven application to lithium-ion battery cell manufacturing are data acquisition, data warehouse and data mining.
Conclusion: The integration of automation and big data in lithium-ion battery manufacturing has positively influenced the quality and quantity of the products.
The Interaction Effect of Nitrogen Levels on Growth Characteristic of Wheat Crop (Triticum aestivum L.)
Authors: Kumar Anil , Kunal  , Sharma Aniket Kumar , Balo Sumana , Gavhale KN , Lanzes Tsering , Raj Ritik , Sachan Kushal
Published: October 2024

The present research work was carried at the Agronomy Farm, Department of Agronomy, Narendra Deva University of Agriculture and Technology, Narendra Nagar (Kumarganj) Faizabad (U.P.), during Rabi season of 2014-2015. This farm is located at a distance of 42 Km. from Faizabad district headquarters at Faizabad – Raibareilly road. The ANOVA of the research trail used a design: randomized block design (factorial) to evaluate growth traits, comprising of initial plant population, plant height (cm), number of shoots (m-2). The data indeed suggested that initial plant population was not significantly influenced by either variety levels or nitrogen levels. Contrastingly, the data showed that variety levels and nitrogen levels significantly affected plant height at 30, 60, 90 days after sowing (DAS) and at harvest. The number of shoots at 30 DAS was not affected significantly by variety levels and nitrogen levels in the data. In addition, Variety levels showed a significant effect on the shoot number at 60 and 90 DAS and also at harvest stage, while nitrogen levels did not show significant effects in growth attributes of wheat under study.