bluuebunny/crossref_metadata_2025 huggingface dataset:
Virtualidad y educación en tiempos de COVID-19. Un estudio empírico en Argentina
Authors: Expósito Cristián David , Marsollier Roxana Graciela
Published: August 2020

Objetivo: explorar las estrategias, recursos pedagógicos y tecnológicos utilizados por los docentes en el modelo de educación virtual implementado durante el confinamiento preventivo y cierre de establecimientos educativos dispuesto ante la situación de emergencia sanitaria mundial por la COVID-19. Método: se trabajó con un diseño metodológico cuantitativo de tipo descriptivo correlacional. Participaron del estudio 777 personas, en su mayoría docentes, que representan a instituciones de distintos niveles educativos de Mendoza, Argentina. Resultados: el análisis de los datos evidenció las desigualdades existentes en cuanto al uso de tecnologías y recursos pedagógicos digitales. Dichas diferencias se manifiestan en relación con el tipo de gestión, el nivel educativo, la situación socioeconómica de los alumnos, el rendimiento académico y el apoyo por parte de la familia del estudiante. Discusión y Conclusiones: los resultados obtenidos ponen en evidencia las desigualdades socioeducativas de los estudiantes. Es necesario continuar profundizando en la comprensión de los condicionantes y las posibles consecuencias que traerán, para el sistema educativo, estas experiencias pedagógicas en aislamiento social.
Do Pátio do Mercado (1899) ao Jardim Público de São Manuel (1929): transformações e permanências
Authors: Silva Adélia Guiomar da , Antonini Lucas Tioda , Enokibara Marta
Published: August 2020

Em 1928, o paisagista paulista Reynaldo Dierberger (1899-1977) projetou a reformulação do Jardim Público de São Manuel, que ainda mantém, até os dias atuais, em linhas gerais, seu desenho e vegetação, principalmente as espécies arbóreas, palmeiras e coníferas. Ao analisar as fotografias disponíveis detectou-se que alguns elementos anteriormente presentes no jardim foram incorporados no projeto de 1928. Neste contexto, a pesquisa objetivou detectar as transformações e permanências ocorridas no espaço. Metodologicamente, a iconografia, a cartografia e as informações textuais (principalmente as Atas da Câmara Municipal) foram trabalhadas comparativamente, de forma a subsidiar a reconstrução do desenho de três situações de transformações que puderam ser identificadas e que estruturam o presente artigo: o largo, com a construção do Mercado Municipal (inaugurado em 1899); o pátio do Mercado e a praça com o coreto (1904); e a reconfiguração do conjunto, com projeto de Reynaldo Dierberger (1928), concluído em 1929. A análise comparativa desses três momentos permitiu identificar a transformação do espaço e a permanência de alguns elementos que foram incorporados ao projeto de 1928, incluindo estudos quanto à vegetação, cujos aspectos formais possibilitaram uma aproximação comparativa.

PALAVRAS-CHAVE: Reynaldo Dierberger. Repertório vegetal. Jardim histórico.
Ethical Considerations and Informed Consent (Part 11 of Phase 3 study of Vaccine Candidate for COVID-19) v1
Authors: Ockenhouse Chris , Gast Chris , Holt Renee , Flores Jorge
Published: August 2020

This is Part 11 of "Phase 3 randomized, double-blinded, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of Vaccine Candidate against COVID-19 in adults > 18 years of age" This generic Phase 3 protocol was developed by the PATH team with support of the Bill and Melinda Gates Foundation. The aim of the collection is to share recommended best practices in designing and implementing a Phase 3 study of a COVID-19 vaccine candidate. As Phase 3 trials of different Vaccine Candidates proceed around the world, following the same protocols will ensure consistency and comparability of the Phase 3 trial results. Please note that this is an evolving document, to be versioned and updated, based on community feedback and new data.
Collection of Protocols and Guidelines forPhase 3 study of Vaccine Candidate for COVID-19 v1
Authors: Ockenhouse Chris , Gast Chris , Holt Renee , Flores Jorge
Published: August 2020

This is a collection of protocols for: "Phase 3 randomized, double-blinded, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of Vaccine Candidate against COVID-19 in adults > 18 years of age" This generic Phase 3 protocol was developed by the PATH team with support of the Bill and Melinda Gates Foundation. The aim of the collection is to share recommended best practices in designing and implementing a Phase 3 study of a COVID-19 vaccine candidate. As Phase 3 trials of different Vaccine Candidates proceed around the world, following the same protocols will ensure consistency and comparability of the Phase 3 trial results. Please note that this is an evolving document, to be versioned and updated, based on community feedback and new data.
Schedule of Study Visits and Evaluations (Appendix A of Phase 3 study of Vaccine Candidate for COVID-19) v1
Authors: Ockenhouse Chris , Gast Chris , Holt Renee , Flores Jorge
Published: August 2020

This is Appendix A of "Phase 3 randomized, double-blinded, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of Vaccine Candidate against COVID-19 in adults > 18 years of age" This generic Phase 3 protocol was developed by the PATH team with support of the Bill and Melinda Gates Foundation. The aim of the collection is to share recommended best practices in designing and implementing a Phase 3 study of a COVID-19 vaccine candidate. As Phase 3 trials of different Vaccine Candidates proceed around the world, following the same protocols will ensure consistency and comparability of the Phase 3 trial results. Please note that this is an evolving document, to be versioned and updated, based on community feedback and new data.
PIPE-RNA-SEQ v1
Authors: Moreira Daniel , Scherer Nicole , Boroni Mariana
Published: August 2020

Esse pipeline foi desenvolvido para análise de dados de RNA-Seq, provenientes de sequenciadores Illumina, para todos os usuários do HPCC-Crab (INCA). De forma breve, o pipeline chamado de PIPE-RNA-SEQ, representado na Figura 1, faz a conversão inicial dos dados (passo opcional) utilizando a ferramenta SamToFastq (http://broadinstitute.github.io/picard/), gera relatórios de qualidade dos dados antes e depois do pré-processamento com o FastQC (https://www.bioinformatics.babraham.ac.uk/projects/fastqc/), executa a retirada de adaptadores e sequências de baixa qualidade com a ferramenta Trimmomatic (BOLGER; LOHSE; USADEL, 2014), faz o mapeamento em um genoma de referência utilizando o STAR (DOBIN et al., 2013) e gera tabelas com as contagens das leituras por gene por cada amostra com o HTSeq (ANDERS; PYL; HUBER, 2015).
Selective laser trabeculoplasty: mechanisms of action and predictors of efficacy
Authors: Kulikov Alexey N. , Kazak Alina A. , Maltsev Dmitrii S.
Published: August 2020

This review considered selective laser trabeculoplasty in comparison with other methods for therapeutic and surgical treatment of primary open-angle glaucoma and ocular hypertension, including argon laser trabeculoplasty. In this paper, we reviewed current knowledge on the mechanisms of action of selective laser trabeculoplasty, predictors of intraocular pressure-lowering effect, repeatability, and safety of this procedure.
Newly Found Dunhuang Fragments of Śatasāhasrikā Prajñāpāramitā in the Collection of the IOM, RAS
Authors: Turanskaya Anna A.
Published: August 2020

the paper presents eleven fragments of Śatasāhasrikā Prajāpāramitā identified during analysis of Khara-khoto collection of Tibetan texts kept in the IOM, RAS. In 2019 as an intermediate result of a project Compilation of the Catalogue of the Tibetan texts from Khara-Khoto preserved at the Institute of Oriental Manuscripts, RAS being done by researchers of the institute thirty-three fragments that had been added to Khara-khoto collection by mistake, were transferred to a separate collection of Tibetan texts from Dunhuang. Although the edited fragments of Śatasāhasrikā Prajāpāramitā cannot be considered to be unique they are worth studying in terms of codicology.
The first leaf of an Old Uyghur 觀無量壽經 Guanwuliangshoujing translation
Authors: Zieme Peter
Published: August 2020

The paper discusses the 觀無量壽經 Guanwuliangshoujing (T. 365) in Old Uyghur. It is an important text of the Pure Land Buddhism known only in its original Chinese text. Several separated fragments in Old Uyghur are known. One fragment of the Turfan Collection in Berlin (U 1499) can be joined with a leaf of the Serindia Collection of the IOM (SI 1748). The result is presented here. One of its interesting differences is the list of 15 Bodhisattvas of which only Majuśrī is given by name in the Chinese original.
Rougier, M. y Sember, F. (coords.) (2018). Historia necesaria del Banco Central de la República Argentina. Entre la búsqueda de la estabilidad y la promoción del desarrollo.
Authors: Rossi Ignacio Andrés
Published: August 2020

No contiene resumen.
Emergency Department Cesarean Section for Placental Abruption; Anticipation from Prehospital History with Preparation for Immediate Delivery
Authors: R Sundararajan , J Speybroeck , M Marsee , FS Shariff , D Czarnecki , A Clark , M Thompson , S Thomas , S Wadsworth , G Wiarda , D Fulkerson , M Walsh , N Zackariya , F Shariff , H Al-Fadhl
Published: August 2020

Emergency department cesarean section for placental abruption is an uncommon surgical procedure that requires anticipation in the prehospital environment as well as preemptive recognition of impending fetal demise by the emergency physician. The presence of an obstetrician ready to perform immediate cesarean section on an unstable patient with placental abruption may be lifesaving for both the mother and the fetus. However, there are no specific guidelines for prehospital recognition of patients with placental abruption that require emergency cesarean section. While the emergency department is not the optimum surgical theatre for an emergency cesarean section, placental abruption often deteriorates so quickly that even a few minutes of delay can have catastrophic consequences for both mother and fetus. We describe a case of placental abruption following moderate motor vehicular trauma in an eight month pregnant woman whose only complaint was moderate abdominal pain. The emergency physician’s suspicion based on the mechanism of injury caused her to mobilize the obstetrician, who was ready to perform an emergency department cesarean section with successful delivery of the fetus. Subsequent managing of the mother’s surgical incision and coagulopathy was performed in the operating room. This case highlights the importance of vigilance that prehospital providers, emergency department physicians, and obstetricians should have for a pregnant patient involved in a motor vehicle crash.
Evaluation of the Indicators of Inflammation in Children and Adolescents with Attention Deficit and Hyperactivity Disorder: Effect of Sex and Subtype
Authors: GÜLER AKSU Gülen , DAĞ Pelin
Published: August 2020

Aim: It was aimed to evaluate the hematological inflammatory markers in treatment-naive and comorbidity-free children and adolescents with attention deficit and hyperactivity disorder (ADHD) in this study.Material and Methods: One hundred sixty-nine children aged 6-18, who were diagnosed with ADHD according to DSM-5 criteria were included in the study. Age and sex-matched 59 healthy children without any psychiatric and/or medical disorder were included as a control group. The children who had an intellectual disability and/or autism spectrum disorder, acute, chronic or inflammatory diseases were excluded from the study. Smoking, obesity and using psychotropic medications and lack of data in records were other exclusion criteria. ADHD and control groups were compared in terms of sociodemographic characteristics, inflammatory markers and hematological parameters.Results: Mean platelet volume (MPV) and Basophil (BASO) levels were significantly higher in the ADHD group compared to the control group and this statistical difference was only observed for boys. In hyperactivity subtype, red cell distribution width (RDW), lymphocyte (LYMPH) and monocytes (MONO) were higher; in attention deficit subtype mean platelet volume-to-lymphocyte ratio (MPVLR) was higher than all other subtypes and control group. MPV was similar in three subtypes, and were higher in all of them than the control group.Conclusion: This study revealed that MPV and BASO tend to be higher in the ADHD group especially in boys. Hematological biomarkers may be useful for diagnosis of ADHD and determination of ADHD subtypes but data on this subject are insufficient and more comprehensive studies are needed.
Protective Effects of Ellagic Acid Against Chemotherapy-Induced Hepatotoxicity
Authors: YALÇIN Alper , KELEŞ Hikmet , KAHRAMAN Tahir , BOZKURT Mehmet Fatih , AYDIN Hasan
Published: August 2020

Aim: Cyclophosphamide (CP) is a commonly used chemotherapeutic agent despite its toxic adverse effects, including hepatotoxicity. Ellagic acid (EA) is an antioxidant agent and exhibits free radical scavenging activities. In this experimental study, the effects of EA on CP-induced liver injury were investigated.Material and Methods: Twenty-four Sprague-Dawley rats (180-220 gr) were separated into four equal groups. A single dose of 150 mg/kg CP was given intraperitoneally to generate hepatotoxicity. Different doses (50 and 75 mg/kg) of EA were administered orally 20 minutes before, 4 and 8 hours after CP administration. The histopathological evaluation of kidney tissues and immunohistochemical evaluation for caspase-3 were conducted as well as the serum biochemical analyses.Results: CP treated group exhibited a significant increase in serum hepatic enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), compared to the control group. Similarly, the total triglycerides (TG) and very-low-density lipoprotein cholesterol (VLDL-C) levels increased significantly. Additionally, the high-density lipoprotein cholesterol (HDL-C) levels decreased, which was not significant, compared to the control group. At both EA doses, VLDL-C, AST, ALT levels decreased significantly while HDL-C level revealed a significant increase. 75 mg/kg EA treatment caused a non-significant elevation in total cholesterol (TC) concentration. Microscopic analysis showed a significant congestion, edema, degeneration and necrosis in the livers of CP administered group. However, edema, degeneration, and necrosis were significantly reduced in animals treated with EA-75. In addition, caspase-3 expression significantly decreased in EA-75 group.Conclusion: These results indicate the protective effects of EA in CP-induced hepatotoxicity in rats.
An Empirical Study of S-commerce Adoption on WeChat Platform
Authors: Ge Mei , Deng Zhongping , He Jing
Published: August 2020

The purpose of this paper is empirically to examine two theoretical models in the context of social electronic commerce (s-commerce). The study tries to extend TAM and UTAUT model with trust to explain consumer behavior in the acceptance of s-commerce on WeChat platform which is the Chinese largest social platform. Through an online survey, 501 valid respondents were collected. A Partial Least Squares (PLS) analysis was used to conduct the proposed model and hypothesis testing with TAM and UTAUT models. The results revealed that trust is the most significant factor affecting behavioral intention and the second significant factor is effort expectancy, then social influence and performance expectancy. The integration of trust factor into the UTAUT model best interprets the adoption of s-commerce among the pure TAM and UTAUT models and extended models with trust. It will provide guidance for marketers and professionals, especially in China.
Spatial Structure Analysis of Leisure Agriculture in Suzhou
Authors: Chen Peng , Zhu Chenchen
Published: August 2020

Based on the analysis of the basic connotation of leisure agriculture, this paper takes the Suzhou city leisure agriculture as the research object to summarize the current situation of leisure agriculture development in Suzhou, the selection of the Suzhou city rural tourism planning (2016-2020) in the key construction project for the leisure agriculture point sample data, analyzes its spatial structure by means of geographic concentration index and Gini coefficient. Through the geographic concentration index is calculated . G is a little less than Goptimal at 44.721. Gini=0.371, C=0.629. According to the research results, leisure agriculture points in Suzhou show a moderate distribution trend, and the leisure agriculture is distributed in various administrative regions of Suzhou city with a high degree of equilibrium, which is conducive to the development of leisure in agriculture. Pertinent suggestions are appropriate to the optimal development path of leisure agriculture in Suzhou.
Antagonistic bacteria for biospace control of roselle spot (Corynespora cassiicola) of Hibiscus sabdariffa
Authors: Patricio-Hernández Alberto , Ortega-Acosta Santo Ángel , Ramírez-Peralta Arturo , Ayala-Sánchez Alejandro , Palemón-Alberto Francisco , Toledo-Hernández Erubiel , Romero-Ramírez Yanet , Toribio-Jiménez Jeiry
Published: August 2020

En años recientes, el manchado de la jamaica inducido por Corynespora cassiicola amenaza la producción de cálices. El objetivo fue determinar si algunas cepas bacterianas inhiben el desarrollo de C. cassiicola in vitro y bajo condiciones de bioespacio. La inhibición del desarrollo fue por confrontación dual de las bacterias: alimentos (20), piel de anfibios (41), jales mineros (22), aire (siete) y rizosfera (10) contra el hongo. Se sembraron plantas de jamaica variedad “criolla” y se inocularon artificialmente con C. cassiicola, a partir del inicio de síntomas de la enfermedad se inocularon las cepas bacterianas seleccionadas con mayor porcentaje de inhibición. Se evaluó la ABCPE. Solo siete cepas inhibieron del 62.7 al 100% el desarrollo del hongo in vitro: Klebsiella pneumoniae (M10-1 y M10-10), Acinetobacter lwoffii (A5), Sphingomonas paucimobilis (NF21), Serratia marcescens (M13ACD), S. liquefaciens (M8ACD) y Acinetobacter sp. (5H2). En relación a la severidad en hojas las cepas M10-1 y M10-10 redujeron el ABCPE en un 9.5 y 12.6%, respectivamente, seguido de NF21 (14.5 de ABCPE), el control registró los mayores niveles (45.7 de ABCPE). Para la severidad en cálices, los análisis del ABCPE de todas las cepas ejercieron control al reducir niveles de severidad (17.1-8.6 ABCPE).
A Retrospective Study of Mortality Causes in Arabian Horses
Authors: Morales-Briceño Abelardo
Published: August 2020

This study aims to describe the causes of death in Arabian horses at Al Wathba, in Abu Dhabi (United Arab Emirates) during 2018-2019. This study was conducted in a cohort of all Arabian horses that died. Data was collected retrospectively and only those horses with a full necropsy report available were included in the study. The carcass and all internal organs of each horse were examined and representative samples of tissues with abnormalities were collected in 10% neutral buffered formalin and processed for histopathological examination. A descriptive statistical analysis was performed. A total of 25 Arabian horses were examined post-mortem. Out of them, 35% were females. In general, colic occurred specifically at a higher frequency (80%), cases of collapse and sudden death during exercise and races occurred in 8%, cases of perinatal death in 8% and one case of laminitis (4%). The annual mortality in relation to the estimated population was 1% approximately. In conclusion, we identified and described the causes of death in Arabian horses in Al Wathba, Abu Dhabi, UAE during the period 2018-2019. In summary, a pathology of the digestive system specifically acute abdominal crisis (colic) is the main cause of death in Arabian horses, with 80%; other causes of mortality with a low incidence were in order collapse and sudden death during exercise and races, perinatal death and laminitis. These results allow establishing risk prevention measures of mortality in horses for specific activities like handling, feeding, training and races
O Poder Dos Espelhos
Authors: Dos Santos Maria Celeste Cordeiro Leite , Araujo Marilene
Published: August 2020

A sociedade refletida no espelho conduz as variáveis possibilidades dos processos e das estruturas do jogo decisório. Na atualidade, o risco é algo que se impõe dada a construção interior de cada subsistema social. O jogo se faz presente na teoria do poder. Na teoria do sistema autopoiético, a comunicação é elemento que constitui a sociedade. O poder é uma comunicação orientada por um código. Assim, como o poder a opinião pública é elevada ao domínio da comunicação e as comunicações possíveis orientam os temas e as opiniões no processo comunicacional. A estrutura dos temas no processo comunicacional é o que estabelece fronteiras daquilo que é possível decidir no sistema político. Os jogos estão diante do espelho.
Las Empresas Multinaciones En El Marco De La Acción 15 De BEPS
Authors: Cipriani Elva Felicia Reátegui
Published: August 2020

as empresas multinacionales deben tener en cuenta que en el plano de la fiscalidad internacional se ha dado un paso firme con la reciente firma del Instrumento Multilateral –IML – para evitar la elusión de impuestos a través de la modificación los convenios fiscales. Este Convenio ya en vigor, fue firmado el 7.06.2017 en París por 76 jurisdicciones, incluida España y modifica de aprox. 1.105 convenios fiscales para evitar la doble imposición – CDIs – de una forma sincronizada, rápida y eficaz. El IML es parte del trabajo impulsado por la OCDE[4] a petición del G-20 en el que se determina un Plan con 15 acciones a seguir para evitar el BEPS (Base Erosion and Profit Shifting). Dicho instrumento es una revolución para la fiscalidad internacional que estuvo orientada a la prevención de la doble imposición y pasa a luchar contra la doble no imposición o abuso de tratados al poner freno a la elusión fiscal planificada agresivamente que realizan las empresas multinacionales.
A Transparência Como Paradigma Da Nova Governance Pública
Authors: António Isa
Published: August 2020

A transparência assume-se como uma condição imprescindível à governance pública inerente ao próprio Estado de Direito Democrático, funcionando como um instrumento garantístico a favor dos direitos do administrado e da sociedade como um todo. O escrutínio sobre a atividade do setor público contribui decisivamente para a atenuação da opacidade e para a “boa administração” através de uma adequada gestão do erário público mormente por virtude de mecanismos de “accountability”. A exigência da transparência faz-se sentir com maior acuidade no âmbito da contratação pública, porquanto a fraude e a corrupção são fenômenos que normalmente surgem associados a este “modo de atuar administrativo” devido às avultadas quantias envolvidas nos contratos públicos. As diversas vertentes de exercício da regulação por parte do “Tribunal de Contas” sobre a contratação pública e o alcance deste controlo externo serão igualmente abordados neste estudo. Por último, procedemos à reflexão sobre a ética e a transparência defendendo a consagração desta como princípio geral da atividade administrativa no Código do Procedimento Administrativo.
Objeção De Consciência Médica E Liberdade De Escolha Do Paciente Terminal No Direito Brasileiro: Como Solucionar O Conflito De Dois Lados Da Mesma Moeda?
Authors: Hogemann Edna Raquel , Paula Lívia Pagani de
Published: August 2020

Realiza uma análise reflexiva sobre o confronto entre os direitos fundamentais da objeção de consciência do profissional da saúde – médico – e a liberdade de escolha do paciente terminal no Direito Brasileiro. O objeto geral da pesquisa é demonstrar a possível compatibilização de uma negativa legítima do médico, que deixa de agir porque a conduta terapêutica representa para ele um grave abalo psicológico, vez que contraria seus valores morais e filosóficos e o direito de liberdade de escolha do paciente em situação de terminalidade. Busca enfatizar que por mais que se prestigie a autonomia da vontade do paciente na finitude da vida, por meio de recusas válidas e das diretivas antecipadas de vontade, o direito do médico, objetor de consciência, não pode ser aniquilado. O objetivo específico é análise das formas de solução desses conflitos, destacando as restrições e limites aplicáveis aos direitos fundamentais, tendo em vista que eles não são absolutos, apontando o instrumento mais adequado para sanar o confronto. A metodologia adotada contempla o método lógico-dedutivo, por meio da pesquisa bibliográfica, adotando como referencial a teoria externa de restrição de direitos fundamentais e o critério de proporcionalidade
Cuidar do Doente Reumático em Tempo de Pandemia: Muito Mais Que Apenas Medicina à Distância
Authors: Fernandes Ana Lúcia , Silva Cândida , Miranda Luís Cunha
Published: August 2020

N/a.
Bir üniversite hastanesinde çalışan hemşirelerde varis sıklığının ve ilişkili faktörlerin değerlendirilmesi
Authors: VAROL Zeynep Sedef , DAVAS Hediye Aslı , ÇİÇEKLİOĞLU Meltem , TÜRK Meral
Published: August 2020

Amaç: Çalışmanın amacı Ege Üniversitesi Tıp Fakültesi (EÜTF) hemşirelerinin Çalışan Sağlığı ve Güvenliği Birimi’nde (ÇASAGÜB) yapılan periyodik muayenelerinde tespit edilen varis sıklığını ve ilişkili faktörleri değerlendirmektir. Yöntem: Kesitsel olarak planlanan araştırma EÜTF’de ÇASAGÜB’ün 2015 yılında periyodik muayene yaptığı 1056 hemşirenin kayıtları ile yapılmıştır. Veri toplama aracı olarak ÇASAGÜB’ün periyodik muayene formu kullanılmıştır. Bulgular: Tüm hemşirelerde varis sıklığı %37.3’tür.  Kadın hemşirelerde erkek hemşirelere göre varis sıklığı istatistiksel olarak anlamlı düzeyde daha yüksektir. Tek değişkenli analizlerde varis sıklığı kadrolu çalışanlarda, cerrahi birimlerde, aylık çalışma saati 160 üstü olanlarda, vardiyalı çalışanlarda, hafta sonu, gece ve icap nöbeti olanlarda anlamlı olarak yüksek saptanmıştır.  Çok değişkenli analizlerde aylık çalışma saati 160 üstü olanlarda varis görülme ihtimali, 160 ve altı saat çalışanlara göre 1.65 kat, icap nöbeti ve hafta sonu nöbeti tutanlarda ise 1.81 ve 1.65 kat fazladır. Sonuç: Bu araştırmada çalışma saatlerinin, vardiyalı çalışmanın ve ergonomik koşulların literatürle uyumlu bir şekilde varis riskini arttırdığı gösterilmiştir. Çalışma saatlerinin ve vardiyaların yasal sınırlara göre düzenlenmesi hemşirelerde varis sıklığını azaltacak en önemli önlemlerden biridir.
İkinci basamak bir devlet hastanesinde erişkin bağışıklama ünitesi deneyimi
Authors: AKDEMİR KALKAN İrem , AKGÜL Fethiye , ÇINAR Güle , MEMİKOĞLU Osman , AZAP Alpay
Published: August 2020

Amaç:
Aşı ile önlenebilir hastalıklardan
korunmanın sağlanması toplum sağlığı açısından oldukça önemlidir. Fakat
ülkemizde erişkin bağışıklama konusunda uygulamada önemli eksiklikler
mevcuttur. Bu çalışmada ikinci basamak bir devlet hastanesi olan Batman Bölge
Devlet Hastanesinde  kurulan ‘Erişkin Bağışıklama
Ünitesi’nin deneyimleri aktarılmıştır. Yöntem:
Kasım  2017-Şubat 2018 tarihleri
arasındaki 3 aylık süreçte ünitede yapılan Hepatit A, Hepatit B ve konjuge pnömokok
aşıları aşı yapılan kişilerin epidemiyolojik özellikleri, aşı endikasyonları ve
yönlendirildikleri klinikler açısından analiz edilmiştir. Bulgular: Kayıtlarının retrospektif incelemesinde toplamda 85
hastaya aşı yapıldığı saptandı. Bu hastaların %35.3’ü (n=30) kadın olarak
saptandı. Hastaların tümü 16 yaş üzeri idi. Yaş ortalaması 57.6 olarak
saptandı. Yapılan aşıların dağılımına bakıldığında %80 (n=68) hastanın konjuge
pnömokok aşısı ile aşılandığı, %17.6 (n=15) hastaya Hepatit B, %2.4 (n=2) hastaya
ise hepatit A aşısı uygulandığı görüldü.Aşılama endikasyonlarına bakıldığında
%5.9 (n=5) hasta 65 yaş üstü olması nedeni ile, %36.5 (n=31)hasta böbrek
yetmezliği nedeni ile, %1.2 (n=1) hasta romatolojik tedavi adayı olması nedeni
ile, %8.2 (n=7) birey evde riskli temaslı birey-tümü Hepatit B açısından-
olması nedeni ile, %4.7 (n=4) birey ise sağlık personeli olduğu için
aşılanırken, %42.4 (n=36) birey ise başta KOAH olmak üzere altta yatan akciğer
hastalıkları nedeni ile aşılanmış olarak tesbit edilmiştir. Sonuç: Erişkin Bağışıklama Merkezleri’
ikinci ve üçüncü basamak sağlık hizmeti veren tüm kurumlar için gereklidir.
Özellikle başvuran hasta sayısının çok ve hasta grubunun da çeşitli olduğu
hastaneler aslında aşı gereksinimi olan hasta popülasyonun da fazla olduğu
hastanelerdir. Aşılanma oranlarını gerekli seviyeye ulaştırabilmek için
hastaneler bünyesinde bu merkezlerin aktif olarak çalışmalıdır.
İlköğretim Birinci sınıf öğrencilerinde diş çürüğü sıklığı ve etkileyen faktörler
Authors: BUĞDAYCI Resul , ŞAŞMAZ Tayyar , ULUDOĞAN Cenk , KURT Ahmet Öner , ÖNER Seva , YAPICI Gülçin , GÖKÇE Hüseyin , ÇOMU Fatih
Published: August 2020

Amaç: İlköğretim birinci sınıf öğrencilerinde, diş çürükleri ve diş çürüğü ile
ilişkili bazı etmenlerin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmanın verileri
Mersin’in Toroslar ilçesinde 2008-2012 yılında yürütülen “Güçlü Dişler”
projesinden alındı. Çalışmaya 41
ilkokulun birinci sınıfında okuyan 4323
öğrencinin 4010’unun verileri dâhil edildi. Öğrenciye ait sosyodemografik
özellikler tanımlayıcı istatistiklerle özetlendi. Diş çürüğü ile ilişkili
olabilecek değişkenlerin araştırılmasında ki-kare, t-test, Linear by linear
association ve lojistik regresyon testleri kullanıldı. İstatistiksel anlamlılık
düzeyi α≤0.05 olarak kabul edildi.  Bulgular:
Çalışmaya alınan 4010 ilköğretim 1.sınıf öğrencisinin %79.5’i yedi yaşında ve
%51.9’u erkekti. Öğrencilerden %48.4’ü daha önce hiç diş hekimine gitmemişti.
Öğrencilerde; ortalama çürük diş sayısı süt dişlerinde 4.4±3.6 (dmf=4.49±3.6),
kalıcı dişlerde 0.4±0.9 (DMF=0.42±1.0), toplam çürük sayısı ise ortalama 4.9
(±3.5)’ti. Süt dişi çürüğü prevalansı erkeklerde (%85.8) kızlara (%82.8) göre
daha fazla (p<0.05), kalıcı diş çürüğü prevalansı ise kızlarda (%20.6)
erkeklere (%17.6) göre daha fazlaydı (p<0.05). Öğrencilerin %25.6’sında en
az bir süt dişi kaybı, %1’inde en az bir kalıcı diş kaybı bulunmaktaydı. Binary logistik regresyon analizi ile
anne eğitiminin yetersiz olmasının 1.84 (CI 1.27-2.67) kat, baba eğitiminin
yetersiz olmasının 1.47 (CI 1.13-1.92) 
kat, çocuğun her gün şeker yemesinin 1.58  (CI 1.18-2.12) kat diş çürüğü olma
olasılığını artırdığı saptanmıştır. Sonuç: Diş fırçalama alışkanlığının,
okul öncesi dönemde kazandırılması gerektiği, ulusal bir politika olarak kabul
edilmelidir. Okullarda velilerin, yapılacak ağız diş sağlığı koruma
programlarına dâhil edilmesi, okul kantinindeki şekerli yiyeceklerin ve
içeceklerin de kontrol altına alınması önerilir.
ASDToolkit: A Novel MATLAB Processing Toolbox for ASD Field Spectroscopy Data
Authors: Elmer Kathryn , Soffer Raymond , Arroyo-Mora J. Pablo , Kalacska Margaret
Published: August 2020

Over the past 30 years, the use of field spectroscopy has risen in importance in remote sensing studies for the characterization of the surface reflectance of materials in situ within a broad range of applications. Potential uses range from measurements of individual targets of interest (e.g. vegetation, soils, validation targets etc.), to characterizing the contributions of different materials within larger spatially-mixed areas as would be representative of the spatial resolution captured by a sensor pixel (UAV to satellite scale). As such, it is essential that a complete and rigorous assessment of both the data-acquisition procedures, and the suitability of the derived data product be carried out. The measured energy from solar-reflected range spectroradiometers is influenced by the viewing and illumination geometries and the illumination conditions which vary due to changes in solar position and atmospheric conditions. By applying corrections, the estimated absolute reflectance (Rabs) of targets can be calculated. This property is independent of illumination intensity or conditions and is the metric commonly suggested to be used to compare spectra even when data are collected by different sensors or acquired under different conditions. By standardizing the process of estimated Rabs, as is provided in the described toolkit, consistency and repeatability in processing are ensured and the otherwise labor intensive and error-prone processing steps are streamlined. The resultant end data product (Rabs) represents our best current effort to generate consistent and comparable ground spectra which have been corrected for viewing and illumination geometries as well as other factors such as the individual characteristics of the reference panel used during acquisition.
Enhancing Secondary Metabolites in Chlorella Sorokiniana Using Alternative Medium with Vinasse
Authors: Machado de Carvalho Emerson , Machado Ramos Matheus , Ansilago Monica , Mussury Rosilda Mara , Velasques Jannaina
Published: August 2020

Microalgae production is expensive and demands high volumes of water and energy to meet all market demands and yet the production of secondary metabolites using alternative media needs deeper studies. Among alternative media, the use of sugar cane vinasse has gained attention for microalgae cultivation. In this work, we’ve compared the biomass yield and secondary metabolites of Chlorella sorokiniana grown in a commercial medium (Sueoka) and in alternative medium prepared with cane vinasse (0.1%) supplemented with N, P2O5 and K2O (commercial formula 20-5-20 g.L-1). The production of microalgae biomass grown in an alternative medium was 2.2% lower, but reached its maximum growth point 14 days faster than the commercial medium. The average level of Phenolic compounds on the commercial medium were 6.02 ± 0.13 mg GAE .g-1 and increased to 15.28 ± 0.32 mg GAE.g-1when C. sorokinianawere grown in the vinasse medium. Same how, Flavonoids contents varied from 13.12 ± 1.33 to 72.30 ± 5.28 mg QE. g-1 to commercial and vinasse medium, respectively. The maximum AOA of C. sorokiniana grown in vinasse medium was 88.05% at a concentration of 1500 µg.mL-1 of extract, with IC50 at 357.7 ± 27.35 µg.mL-1. Different factors seem to induce variances on secondary metabolites synthesis, mostly stress due to QOD and ions added to the medium by vinasse. The authors recognize there are more investigations to be done, but increasing a natural and low cost pathway for flavonoids yield open up an interesting field for the bioprospection of microalgae.
Control of Transcription Initiation by Biased Thermal Fluctuations on Repetitive Genomic Sequences
Authors: Imashimizu Masahiko , Tokunaga Yuji , Afek Ariel , Takahashi Hiroki , Shimamoto Nobuo , Lukatsky David
Published: August 2020

In the process of transcription initiation by RNA polymerase, promoter DNA sequences affect multiple reaction pathways determining the productivity of transcription. However, the question of how the molecular mechanism of transcription initiation depends on sequence properties of promoter DNA remains poorly understood. Here, combining the statistical mechanical approach with high-throughput sequencing results, we characterize abortive transcription and pausing during transcription initiation by Escherichia coli RNA polymerase at a genome-wide level. Our results suggest that initially transcribed sequences enriched with thymine bases represent the signal inducing abortive transcription. On the other hand, certain repetitive sequence elements broadly embedded in promoter regions constitute the signal inducing pausing. Both signals decrease the productivity of transcription initiation. Based on solution NMR and in vitro transcription measurements, we also suggest that repetitive sequence elements of promoter DNA modulate the rigidity of its double-stranded form, which profoundly influences the reaction coordinates of the productive initiation via pausing.
Anti-diabetic Effects of Wild Soybean Glycine Soja Seed Extract on Type 2 Diabetic Mice and Human Hepatocytes induced Insulin Resistance
Authors: Son Eunjung , Choi Hye Jin , Kim Seung-Hyung , Jang Dong-Gyu , Cha Jimin , Choi Jeong June , Kim Mee Ree , Kim Dong-Seon
Published: August 2020

Anti-diabetic effects of Glycine soja seed extract (GS) on Type 2 diabetes mellitus mouse model and human hepatocytes induced insulin resistance were investigated. 3 weeks old db/db mice were divided into 5 groups (n = 6) including two control groups and 3 GS treated groups with different doses. Oral administration of GS for 6 weeks to diabetic db/db mice reduced blood glucose level significantly in a dose dependent manner by 44.7% (300 mg/kg/day), 30.9% (150 mg/kg/day) and 21.1% (75 mg/kg/day). GS treatment also lowered significantly plasma level of HbA1c, insulin, IGF-1 and leptin, and increased that of adiponectin. GS treatment activated AMPK, and down-regulated GLUT2 in liver tissues of mice while up-regulated GLUT4 in muscle tissues of mice. In in vitro study with insulin resistance induced human hepatocyte, GS treatment increased glucose uptake and increased the activities of Akt and PPAR-γ in response to insulin. Treatment of GS appears to reduce blood glucose level by regulating energy metabolism positively through various metabolic pathways and reducing insulin resistance in Type 2 diabetes mellitus.
Total Hip Arthroplasty Versus Hemiarthroplasty for Displaced Femoral Neck Fracture
Authors: Ekhtiari Seper , Gormley Jessica , Axelrod Daniel E. , Devji Tahira , Bhandari Mohit , Guyatt Gordon H.
Published: August 2020

Background:

Hip fractures are a leading cause of disability worldwide, with displaced femoral neck fractures being of particular concern. A recent meta-analysis reported that total hip arthroplasty (THA) was superior to hemiarthroplasty (HA) in terms of reoperations, but inferior in terms of dislocations. However, publication of 4 additional randomized controlled trials that enrolled nearly 1,780 additional patients merits an updated meta-analysis.

Methods:

We conducted a literature search of 4 databases to identify randomized controlled trials comparing THA and HA in patients with displaced femoral neck fractures. For patient-reported outcomes, the minimally important difference informed calculation of risk differences. We performed a subgroup analysis to address the possible impact of risk of bias and performed meta-regression to assess the possible impact of duration of follow-up.

Results:

Sixteen studies that enrolled 3,084 patients randomized to undergo THA (n = 1,521) or HA (n = 1,563) proved eligible. There were no significant differences between the 2 groups in terms of the revision rate at up to 5 years of follow-up or functional outcome at up to 3 years. Health-related quality of life was superior in the THA group (mean difference [MD] = 0.05, 95% confidence interval [CI] = 0.02 to 0.07, minimally important difference, 0.145). There was no significant difference between the groups in terms of dislocation or periprosthetic fracture incidence. Operative time was significantly shorter in the HA group (MD = 22 minutes, 95% CI = 9 to 35 minutes). Analyses addressing risk of bias and length of follow-up did not reveal subgroup differences. Certainty of evidence for all outcomes was rated as moderate.

Conclusions:

The best evidence showed, with moderate certainty, that HA and THA likely result in similar revision rate, function, mortality, periprosthetic fracture, and dislocation at up to 5 years, with a small, possibly unimportant benefit in health-related quality of life with THA. More specifically, the improvements are well below established cutoffs for clinical importance. Almost half of all patients were from a single large randomized controlled trial, although the results were consistent across the studies. In addition, HA likely results in a clinically unimportant reduction in operative time.

Level of Evidence:

Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Design of Temperature and Humidity Control Systems in Quail Puppies Cages Using Fuzzy Logic Method
Authors: Yahya Mochtar , Erwanto Danang
Published: August 2020

After the quail eggs hatch, quail chicks need a warm place as a substitute for the mother to maintain body temperature. The temperature needed by quail chicks is approximately 37°C in the first week and each following week the temperature is lowered to room temperature of 28°C. This research applies the control of temperature and humidity of quail chicks based on fuzzy logic Tsukamoto method. As a detector of temperature and humidity on drums used DHT11 sensor. This temperature and room control system is designed to reduce mortality in quail chicks. The average temperature and humidity reading error for quail puppages by using the DHT 11 sensor is 1% of the temperature reading and 2% of the humidity reading. The results of the implementation of fuzzy logic control are able to maintain the stability of temperature and humidity in quail chicks cages at 32°C – 38°C with humidity between 40% RH – 70% RH.
Design of Wheeled Football Robot Coordination System at Base Station Using TCP / IP
Authors: Kusumastutie Diah Arie Widhining , Alif Fiolana Farrady
Published: August 2020

Wheel Soccer Division, Indonesian Robot Contest is an annual competition held by the Ministry of Education. One team in this division consists of 3 robots connected in wireless communication coordinated by base station. Besides that, base station computer also connects the robots with referee computer or called Refbox (Referee Box). Refbox as server for base station computer and base station computer as server for robots. The problem arises in base station has to play double roles, as server and client. In testing had two the results of communication from the referee box to basestation and basestation to the client so the data from the referee box can be accepted by the client with a success rate of 93%.
Student Perceptions of Online Learning During the Covid-19 Pandemic
Authors: Wijayanengtias Marta , Claretta Dyva
Published: August 2020

From the emergencies of COVID-19, the government made a policy of learning from home including lectures. But in its procurement, online lectures have many notes, especially from students as one of the online lecturers part. This study aims to determine the perceptions of students in Surabaya about online lectures when the COVID-19 pandemic. The Surabaya study is a research location because Surabaya is the second largest city after Jakarta which has the highest COVID-19 case in East Java Province. Researchers use the theory of Kenneth K. , Edward M. , Judy C. Pearson and Paul E. Nelson in (2008) about the stages of the process of perception, namely stimulation (sensation), attention, and interpretation. The method used is qualitative. The informants in this study were active students at the 10 best universities in East Java according to . In addition to using interview techniques, researchers also made observations on the 10 university's official social media accounts. As a result, students in Surabaya perceived that online lectures during a pandemic were good enough to reduce the spread of the corona virus. But in its implementation, students feel less satisfied with several aspects, one of which is the online learning support facilities provided by the campus such as the internet quota, even though the intensity of the assignments is greater than face-to-face lectures.
Bacterial profile, antibiotic susceptibility pattern and associated risk factors of urinary tract infection among clinically suspected children attending at Felege-Hiwot Comprehensive and Specialized Hospital, Northwest Ethiopia. A prospective study
Authors: Fenta Adugna , Dagnew Mulat , Eshetie Setegn , Belachew Teshome
Published: August 2020

Background: Urinary tract infection is one of the most common bacterial infections in children. Understanding the characteristics of uropathogens and their antimicrobial susceptibility pattern in a particular setting can provide evidence for the appropriate management of cases. This study aimed to assess the bacterial profile of urinary tract infection, their antimicrobial susceptibility pattern and associated factors among clinically suspected children attending at Felege-Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia.Methods: A hospital-based cross-sectional study was conducted from February-April, 2019. A systematic sampling technique was employed. A mid-stream urine sample was inoculated on cystine lactose electrolyte deficient media and incubated for 24-48 hours. Sub-culturing was done on Mac-Conkey and blood agar. Antimicrobial susceptibility test was done on Muller-Hinton agar. A binary logistic regression model was used to see the association between dependent and independent factors. A p-value<0.05 at 95% CI was considered as statistically significant.Results: The overall prevalence of urinary tract infection was 16.7% (95% CI 12.4-21.1). Both Gram-negative and Gram-positive bacterial isolates were recovered with a rate of 44/50 (88%) and 6/50 (12%) respectively. Among Gram-negative isolates, E. coli 28/44(63.6%) was predominant while S. saprophyticus 2/6(33.3%) was prevalent among Gram-positive bacterial isolates. Overall, a high level of resistance to ampicillin, Augmentin, and tetracycline was shown by Gram-negative bacteria with a rate of 44/44(100%), 39/44(88.6%), and36/44 (81.8%) respectively. About 33/50(66%) of overall multidrug resistance was observed (95% CI 52-78). About six Gram-negative bacterial isolates were extended spectrum beta-lactamase (ESBL) producers. Having a history of urinary tract infection (P-0.003, AOR 1.86-22.15) and male uncircumcision (p-0.00, AOR 5.5-65.35) were the independent variables that associate for urinary tract infections.
Clinical value of selected markers of angiogenesis, inflammation, insulin resistance and obesity in type 1 endometrial cancer
Authors: Terlikowska Katarzyna M. , Dobrzycka Bozena , Terlikowski Robert , Sienkiewicz Anna , Kinalski Maciej , Terlikowski Sławomir Jerzy
Published: August 2020

Background: It is a well-known fact show that the risk of developing endometrial cancer (type 1 EC) is strongly associated with obesity. In this study, selected markers, such as obesity, insulin resistance, angiogenesis and inflammation markers related to EC type 1 progression and patients’ survival data were analyzed.Methods: To measure levels of adiponectin, C-reactive protein (CRP), vascular endothelial growth factor-A (VEGF-A), angiopoietin-2 (Ang-2), insulin-like growth factor-1 (IGF-1), insulin and C-peptide in 176 preoperative serum samples, the immunoassay technique (EMIT) has been applied.Results: Angiopoietin-2 levels increase with age (P=0.005), FIGO stage (p=0.042), myometrial invasion (P=0.009) and LVSI (P<0.001). The CRP levels increase with age (P=0.01), as well as the advancement of the FIGO stage (P<0.001), higher tumor grade (P=0.012), and myometrial invasion (P<0.001). A positive correlation between serum Ang-2 and CRP levels was demonstrated (r=0.44; p<0.001). Kaplan-Meier survival analysis showed that patients with high CRP levels in serum and Ang-2 presented a worse outcome (P=0.03 and P=0.015, respectively). Cox regression analysis of individual predictors revealed that high serum levels of Ang-2, CRP, advanced clinical FIGO stage (P<0.001, respectively), old age (P=0.013) were all significant overall survival predictors. By means of multivariate analysis, their predictive significance was confirmed.Conclusion: Our study provides evidence that serum levels of Ang-2 and CRP may serve as predictors for assessment of the clinical stage of type 1 EC and are significantly associated with poor prognosis. It is likely that angiogenesis and inflammation associated with obesity have a significant impact on EC type 1 progression and survival rate of patients.