bluuebunny/crossref_metadata_2025 huggingface dataset:
First report of IgE sensitization to Anisakis simplex in a healthy population in Colombia
Authors: Castellanos-Garzón Jenniffer A. , Ubeira Florencio M. , Pustovrh María Carolina , Salazar Liliana , Daschner Álvaro , Cuéllar Carmen
Published: August 2022

The anisakiasis is little known in Colombia and rarely diagnosed. However, reports of fish parasitized by anisakid larvae in South America are increasing. Objectives: The objective was determine the prevalence of sensitization to Anisakis simplex in a healthy population in Colombia Methods: Cross-sectional survey of 150 volunteers from Universidad del Valle’s community, Cali, Colombia. Past medical history, including eating habits associated with fish consumption was assessed. Prevalence of IgE antibodies was determined by the ELISA- Trisakis 170 kit for the recombinant allergens Ani s 1 and Ani s 7. Findings: Two sera (1.3%) of blood tested were positive to the Ani s 7 antigen, while for Ani s 1 all sera were negative. Conclusions: This research is the first exploratory study on Anisakis prevalence conducted in Colombia, the results do not indicate a major problem. Nevertheless, more epidemiological studies are needed.
Caracterización transcriptómica de bacterias relacionadas con eubiosis y disbiosis en pacientes con y sin carcinoma escamocelular oral
Authors: Erira Alveiro , Gamboa Fredy , Cid-Arregui Ángel , Tobar-Tosse Fabian , García Dabeiba A.
Published: August 2022

Objetivo. Caracterizar la expresión génica de 40 especies bacterianas compatibles con procesos de eubiosis y disbiosis en pacientes con y sin OSCC Material y Método. Se realizó un estudio descriptivo de corte transversal en muestras de placa y saliva de 10 pacientes con OSCC y 10 sin OSCC con géneros y edades similares, mínimo 4 dientes en boca. ARN total fue extraído y secuenciado mediante HiSeq™ 2500 de Illumina. Se analizaron secuencias con herramientas bioinformáticas (trimmomatic, SortMeRNA, BMTagger, RNA-Seq, bowtie2 y kraken2) y bases de datos (PATRIC, CARD, VICTORS). Resultados. El grupo de eubiosis S. macedonicus, S. lutetiensis, S. infantarius, S. parauberis, L. helveticus, T. intermedia, S. novella y E. asburiae expresaron 169 genes, y el grupo de disbiosis L. pneumophila, M. hominis, M. conjunctivae, G. vaginalis, C. canimorsus, P. stuartii expresaron 76 genes, la actividad transcripcional se relacionó con metabolismo de carbohidratos, nucleótidos, aminoácidos y energía, que a su vez se asoció con resistencia a antibióticos, factores de virulencia, blancos de medicamentos y transporte. Conclusión. La actividad transcripcional de S. macedonicus, S. infantarius, S. lutetiensis, S.pasteurianus, S. parauberis, C. violaceum y S. novella se asocia con procesos de eubiosis y T. intermedia y P. stuartii con procesos de disbiosis.
Trauma, poisoning and envenomation caused by fish in Brazil: a review
Authors: Novelli Matheus M , Feio Renato N , Montenegro Stefania S P , Ribeiro-Júnior Ademir N , Siqueira-Batista Rodrigo
Published: August 2022

Injuries caused by traumatic, poisonous and venomous animal are relatively common in the medical practice of many regions, especially in tropical countries, such as Brazil. These include morbid events caused by a wide variety of fish. Although they are generally of low severity, restricted to local manifestations of the place where the venom/poison comes into contact with the skin or mucosa, these illnesses can evolve to more severe conditions which, in rarer cases, can lead to death. The potential severity in some cases, along with the recent increase in the number of notifications, in different areas of the country, demonstrate the need for a better understanding of these events. Based on these considerations, the present article aims to review the literature on the main characteristics of trauma, poisoning and envenomation by fish in Brazil, with emphasis on the causative animals and on the pathophysiological, clinical and therapeutic aspects of these morbid conditions
Lysinebacillum Bacteriemia in an Adult Cancer patient
Authors: Martinez-Vernaza Samuel , Garzon-Herazo Javier , Garcia-Guzman Katherine , Cuervo-Maldonado Sonia Isabel
Published: August 2022

Lysinibacillus is a genus of rod-shaped gram-positive bacteria most often found in soil and plantlife, however, it has been isolated from air and from the human intestinal microbiome as well. The genus Lysinibacillus is most often disregarded when isolated in the laboratory; nevertheless, it usually acts as an opportunist in immunocompromise hosts with various mortality rates. Here we present a case of bacteriemia due to Lysinibacillus in a patient whose clinical history and risk factors suggested otherwise. It is crucial to pay attention to the identification of this types of organisms, particularly, when they come from techniques such as spectroscopy. This in order to have a broader picture when addressing this type of patients.
Ergotamina y terapia antiretroviral: una combinación peligrosa. Reporte de caso
Authors: Hernandez-Torres Juan M. , Rivera-Tenorio Ayleen D. , Moreno-Ortega Stephanya , Arbeláez-Cortes Álvaro , Chamorro Yany Magali , Segura-Cheng Janier D.
Published: August 2022

El ergotismo es una condición clínica rara caracterizada por vasoconstricción generalizada producida por la administración de medicamentos derivados del Ergot. Principalmente mediado por la interacción entre medicamentos, entre ellos figuran los antibióticos, anticonceptivos orales y antivirales. Se presenta el caso de un paciente de 28 años, con infección por virus de la inmunodeficiencia humana en manejo antirretroviral con inhibidores de la proteasa que consumió concomitantemente ergotamina con lo cual desarrollo dolor intenso, frialdad, parestesias y cianosis de los miembros inferiores asociado a una lesión ulcerada en el dorso del pie derecho, se consideró episodio de vasoespasmo secundario a ergotismo, dentro del diferencial toman relevancia las vasculitis. Presentó mejoría tras la suspensión de los medicamentos que estaban relacionados y el uso de vasodilatador. El propósito del caso es hacer énfasis en una interacción medicamentosa grave como lo es la de la ergotamina más inhibidores de la proteasa.
Reacción similar a la enfermedad del suero secundaria al uso de cefalotina: reporte de un caso
Authors: Sepúlveda-Barbosa Germán , Montoya-Giraldo Maria A. , Restrepo-Chavarriaga Gabriel , Zuluaga Andres F.
Published: August 2022

La enfermedad del suero (SS, por sus siglas en inglés) y las reacciones similares a la SS (SSLR) son entidades clínicas indistinguibles pero con procesos fisiopatológicos diferentes, particularmente respecto al impacto en el sistema del complemento. La base de datos VigiAccess™ sólo contiene 3 casos potenciales de SS entre 2890 registros para cefalotina reportados entre 1968 y diciembre de 2021, pero ninguno de SSLR. Este antibiótico de uso común fue aprobado en 1974, y sus primeros estudios clínicos describieron que la totalidad de voluntarios sanos podían producir SSLR dependiendo de la dosis y velocidad de infusión. Aquí presentamos el caso de una mujer joven, previamente sana, quien sufrió un accidente ofídico y se le administró antiveneno y cefalotina, tras lo cual desarrolló aparentemente SS, requiriendo re-hospitalización, pero debido a que no hubo consumo de complemento, y su recuperación fue total y sin complicaciones, se definió como una probable SSLR.
Sitting and Standing Intention Detection based on the Complexity of EEG Signal
Authors: Chang Wenwen , Nie Wenchao , Yuan Yueting , Zhang Yuchan , Yan Guanghui
Published: August 2022

Based on the brain signals, decoding the gait features to make a
reliable prediction of action intention is the core issue in the brain
computer interface (BCI) based hybrid rehabilitation and intelligent
walking aid robot system. In order to realize the classification and
recognition of the most basic gait processes such as standing, sitting
and quiet, this paper proposes a feature representation method based on
the signal complexity and entropy of signal in each brain region.
Through the statistical analysis of the parameters between different
conditions, these characteristics which sensitive to different actions
are determined as a feature vector, and the classification and
recognition of these actions are completed by combing support vector
machine, linear discriminant analysis and logistic regression.
Experimental result shows that the proposed method can better realize
the recognition of the above-mentioned action intention. The recognition
accuracy of standing, sitting and quiet of 13 subjects is higher than
81%, and the highest one can reach 87%. The result has significant
value for understanding human’s cognitive characteristics in the process
of lower limb movement and carrying out the study of BCI based strategy
and system for lower limb rehabilitation.
Metabolomics characterization of life-history strategies of scleractinian corals in the South China Sea: comparation of a dominant coral (Pocillopora meandrina) and a nondominant coral (Seriatopora hystrix)
Authors: Pei Jiying , Hu Junjie , Wang Yitong , Zhang Jingjing , Qin Zhenjun , Zhang Ruijie , Kuo Tinghao , Chung Hsinhsiang , Hsu Chengchih , Yu Kefu
Published: August 2022

Life-history strategies play a critical role in susceptibility to
environmental stresses for scleractinia coral. Metabolomics, which is
regarded as the ultimate response of biological systems to genetic and
environmental changes, is competent for the characterization of species’
biological traits. In this study, we combined untargeted mass
spectrometry metabolomics and molecular networking to characterize the
differential metabolic pathways between Pocillopora meandrina, one of
the dominant species in South China Sea (SCS) with the life-history
strategy of “competitive”, and Seriatopora hystrix, one of the
nondominant species with the life-history strategy of “weedy” in SCS.
The results show that lyso-PAF, DGCC, aromatic amino acids, and
sulfhydryl compounds were more enriched in P. meandrina, whereas new
phospholipid, de-PG DHC, MAG, FA (C<18), peptides, and
guanidine compounds were more enriched in S. hystrix. The metabolic
pathways involving immune response, energy metabolism, cellular membrane
structure regulation, oxidative stress system, secondary metabolite
synthesis, and et al. were speculated to relate to coral’s physiological
traits, which finally resulted in the faster growth rate of P. meandrina
and more robust environmental adaptability of S. hystrix. This study
contributed to understanding of the potential molecular traits
underlying life-history strategies of different coral species.
Phylogeography of the blacklegged tick Ixodes scapularis throughout the United States identifies candidate loci for differences in vectorial capacity
Authors: Frederick Julia , Thompson Alec , Sharma Prisha , Dharmarajan Guha , Ronai Isobel , Pesapane Risa , Smith Ryan , Sundstrom Kellee , Tsao Jean , Tuten Holly , Yabsley Michael J. , Glenn Travis
Published: August 2022

The blacklegged tick, Ixodes scapularis, is a vector of Borrelia
burgdorferi sensu stricto (s.s.), the causative agent of Lyme disease,
part of a slow-moving epidemic of Lyme borreliosis spreading across the
northern hemisphere. There are well-known geographic differences in the
vectorial capacity of these ticks associated with genetic variation.
Despite the need for detailed genetic information in this disease
system, previous phylogeographic studies of these ticks have been
restricted to relatively few populations or genetic loci. Here we
present the most comprehensive phylogeographic study of I. scapularis
conducted by using 3RAD and surveying 353 ticks from 33 counties
throughout the range of I. scapularis. We found limited genetic
variation among populations from the Northeast and Upper Midwest, where
Lyme disease is most common, and higher genetic variation among
populations from the South. We identify four genetic clusters of I.
scapularis that are consistent with four major geographic regions, plus
a distinct Central Florida group. In regions where Lyme disease is
increasing in frequency, the I. scapularis populations genetically group
with ticks from historically highly Lyme-endemic regions. Finally, we
identify ten variable DNA sites that contribute the most to population
differentiation. These variable sites cluster on one of the
chromosome-scale scaffolds for I. scapularis and are within identified
genes. Our findings illuminate the need for additional research to
identify loci causing variation in the vectorial capacity of I.
scapularis and where additional tick sampling would be most valuable to
further understand disease trends caused by pathogens transmitted by I.
scapularis.
Hsp70 in combination with IL-15 and PD-1 blocker interferes induction of cytotoxic NK cells in patients with relapsed acute myeloid Leukemia (AML)
Authors: Firouzi Javad , Hajifathali Abbas , Azimi Masoumeh , Ghaemi Fatemeh , Asl Amir Abbas Hedayati , Safa Majid , Ebrahimi Marzieh
Published: August 2022

Background: Natural killer cells are critical immune cells for
AML targeting. However, little is known about the relationship between
using checkpoint inhibitors and Hsp70 as NK cell activators and later
immune responses to control AML. We aimed to investigate the antitumor
effects of NK cells pre-treated with ex-vivo Hsp70, human PD-1 blocker,
and IL-15. Procedure: The NK cells were isolated from
patients-derived MNCs using MACS and activated using the different
combinations of Hsp70, PD-1 blocker, and IL-15. Then their killing
potential and the expression pattern of PRF-1, PIK3CB,
PD-1, AKT-1, FAS-L, TRAIL, and GER A
& B were estimated. Results: Our data revealed that the PD-1
expression was significantly reduced after NK cell activation with the
different formulas of NK cell activators. Also, the expression of NKG2A
was reduced, particularly in the IL-15 and IL-15 + PD-1 blocker treated
groups, and adding the Hsp70 increased its expression. Moreover, the
cytotoxic effect of NK cells increased in all groups, especially in
IL-15 + PD-1 blocker group, in parallel with increasing in IFN-γ
releasing, Granzymes, and perforin expression. All changes in IL-15 +
PD-1 blocker groups were associated with the up-regulation of
PIK3CB and AKT-1 as key factors of NK cell activation. The
presence of Hsp70 reduced IFN-γ releasing and down-regulation of
PIK3CB, AKT-1, Granzymes, and perforin.
Conclusions: We suggested that combining IL-15 and PD-1
blockers could enhance the killing potential of AML-NK cells. Moreover,
Hsp70, in combination with IL-15 and PD-1 blocker, interferes activation
of AML-NK cells through unknown mechanisms.
Pena-Shokeir Syndrome's first case report from Syria
Authors: Almoshantaf Mohammad , Alibrahim Hidar , Bohsas Haidara , Alabdo Shorouk , Nashwan Abdulqadir , Swed Sarya
Published: August 2022

Pena-Shokeir Syndrome is considered to be a fatal congenital condition
that is rarely diagnosed in neonates. We present the first ever reported
case of Pena-Shokeir Syndrome from Syria. Both clinical assessment and
early prenatal diagnosis are necessary to give more realistic options
for the mother and the baby.
Developmental endothelial locus-1 in cardiovascular and metabolic diseases: a promising biomarker and therapeutic target
Authors: Zhao Mengmeng , Zheng Zihui , Li Chenfei , Wan Jun , Wang Menglong
Published: August 2022

Cardiovascular and metabolic diseases (CVMDs) are a leading cause of
death worldwide and imposes a huge socioeconomic burden on individuals
and healthcare systems, underscoring the urgent need to develop new drug
therapies. Developmental endothelial locus-1 (DEL-1) is a secreted
multifunctional domain protein that can bind to integrins and play an
important role in the occurrence and development of various diseases.
Recently, DEL-1 has attracted great interest for its pharmacological
role in the treatment and/or management of CVMDs. In this review, we
present the current knowledge on the predictive and therapeutic role of
DEL-1 in a variety of CVMDs, such as atherosclerosis, hypertension,
cardiac remodeling, ischemic heart disease, obesity, and insulin
resistance. Collectively, DEL-1 is a promising biomarker and therapeutic
target for CVMDs.
Sequencing our way to more accurate community abundance
Authors: Brennan Georgina
Published: August 2022

Over the last two decades, there has been a huge increase in our
understanding of microbial diversity, structure and composition enabled
by high throughput sequencing (HTS) technologies. Yet, it is unclear how
the number of sequences translates to the number of cells or species
within the community. Additional observational data may be required to
ensure relative abundance patterns from sequence reads are biologically
meaningful or presence absence data may be used instead of abundance.
The goal is to obtain robust community abundance data, simultaneously,
from environmental samples. In this issue of Molecular Ecology
Resources, Karlusich et al., (2022) describe a new method for
quantifying phytoplankton cell abundance. Using Tara Oceans datasets,
the authors propose the photosynthetic gene psbO for reporting accurate
relative abundance of the entire phytoplankton community from
metagenomic data. The authors demonstrate improved correlations with
traditional optical methods including microscopy and flow cytometry,
improving upon current molecular identification typically using rRNA
markers genes. Furthermore, to facilitate application of their approach,
the authors curated a psbO gene database for accessible taxonomic
queries. This is an important step towards improving species abundance
estimates from molecular data and eventually reporting of absolute
species abundance, enhancing our understanding of community dynamics.
Primary cardiac tumor: a case report of right atrial angiosarcoma and review of the literature
Authors: Guo Yujian , Liu Qianzhen , Wu Haibo
Published: August 2022

Background: Primary cardiac angiosarcoma is a rare cardiac
tumor. Most of them grew in the right atrium, often invading the
superior vena cava and pericardium. The clinical symptoms of majority
patients may present right heart failure, superior vena cava
obstruction, and even pericardial tamponade. Case presentation:
In this case report, we presented a 76-year-old man presented with chest
tightness, fatigue, pericardial effusion, and arrhythmia. The
transthoracic echocardiography (TTE) showed that a mass in the right
atrium. Histopathology and immunohistochemistry confirmed the diagnosis
of angiosarcoma. The patient was discharged from hospital after surgery.
Conclusions: For the patients with early stage cardiac
angiosarcoma without evidence of metastasis, radical resection of the
primary tumor remains the most important approach for optimal survival.
Comforting Things: cherished possessions as sources of social comfort and security, from the Palaeolithic to the present
Authors: Spikins Penny
Published: August 2022

All around us, almost all the time, we see objects with no obvious function that seem to play an important role in our lives. This apparently bizarre obsession with non-functional objects is one of the most obvious differences between ourselves and other animals. Our lives are filled with all kinds of objects, not just those with a practical function but a whole range of mementos such as photographs, or treasured childhood toys, or necklaces or bracelets whose special place in our hearts has little to do with physical appearance. Although many non-industrialised societies are far less materialistic, even constantly mobile hunting and gathering populations create and attach meaning to objects such as beads, figurines or amulets, which do not have any immediate practical function. Here, we consider the extent to which new emotional vulnerabilities may explain our apparently bizarre emotional attachment to certain treasured things and provide an explanation for the creation, significance and movement of many non-functional things in the archaeological record. We draw together evidence for an often-overlooked characteristic of cherished possessions – their capacity to provide comfort and a sense of connection and counteract loneliness. We then consider the characteristics of those kinds of objects that particularly inspire a sense of comfort and security in our own societies and the extent to which these characteristics can also be found in archaeological artefacts from the Upper Palaeolithic. There will have been many other aspects of meaning that are important in the creation and use of non-functional things by Palaeolithic societies. Nonetheless, the significance of new emotional vulnerabilities, and compensatory attachments to objects, appears to provide important insights. By moving away from the concept that our own species – modern humans – must have had a superior mind to other humans, we can begin to better understand how new vulnerabilities may have been integral to community resilience. Understanding how we came to rely on cherished objects to bring us a sense of emotional security also leads to a better understanding of our human vulnerabilities and our need for warmth and social connection.
Does digital economy promote sustainable development: Case of EU countries?
Authors: Skvarciany Viktorija , Jurevicienė Daiva
Published: August 2022

The digital economy and sustainable development are treated as the world?s progress, and there is a vast number of papers investigating the indirect linkage between these two phenomena. However, there is a lack of studies analysing the direct influence. Hence, the purpose of the current paper is to find out if there is an impact of the digital economy, expressed by DESI sub-dimensions, on sustainable development, represented by SDGI. For that issue, statistical data covering 2017-2020 was gathered, and panel regression modelling was applied. The survey covers 28 EU countries (including the United Kingdom because the data was collected before Brexit). The findings revealed that DESI sub-dimensions influence SDGI; however, the impact was negative in most cases. Thus, the current paper showed that standard views on the influence of the digital economy are not always the right ones.