bluuebunny/crossref_metadata_2025 huggingface dataset:
First Report of the Dinoflagellate Genus Effrenium in the East Sea of Korea: Morphological, Genetic, and Fatty Acid Characteristics
Authors: Kang Nam Seon , Kim Eun Song , Lee Jung A , Kim Kyeong Mi , Kwak Min Seok , Yoon Moongeun , Hong Ji Won
Published: May 2020

Most species in the family Symbiodiniaceae are symbiotic partners to invertebrate and protist hosts, but a few live freely in water columns. Here, a free-living dinoflagellate was isolated from the waters off the Dokdo Islands in the East Sea of Korea. Morphological and molecular analyses show this isolate belongs to Effrenium voratum. Prior to the present study, E. voratum had been reported to live in the waters in the temperate latitudes in the western North Pacific, the southwest Western Pacific, the eastern North Pacific, the eastern Atlantic, and the Mediterranean Sea. To our knowledge, this is the highest latitude in the western North Pacific, where E. voratum has been reported. This report extends the known range of this dinoflagellate to the temperate waters of the western North Pacific Ocean. The sequence of the D1/D2 region of the large subunit ribosomal DNA (LSU rDNA) was identical to E. voratum found in Jeju Island, Korea, Tsushima Island, Japan, and Cook Strait, New Zealand, suggesting this species is cosmopolitan. However, it was different by 1 bp from those found in Blanes, Spain and Santa Barbara, USA. In the phylogenetic tree built on the basis of the LSU (D1-D2) rDNA region sequences, this dinoflagellate was clustered within a clade, including all the other E. voratum strains. Morphological characteristics were like those of strains found in the waters of Jeju Island. This is the first report conducted on the fatty acid profile of fully characterized E. voratum. Importantly, the isolate possessed a high ratio of long-chain omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) relative to total lipid. This dinoflagellate could be a candidate for commercial applications, such as aquaculture feed and essential omega-3 PUFA productions.
Sustainable Cultural Heritage Planning and Management of Overtourism in Art Cities: Lessons from Atlas World Heritage
Authors: De Luca Giuseppe , Shirvani Dastgerdi Ahmadreza , Francini Carlo , Liberatore Giovanni
Published: May 2020

In recent years, there has been an increase in international tourist arrivals worldwide. In this respect, Art Cities are among the most favorable tourist destinations, as they exhibit masterpieces of art and architecture in a cultural environment. However, the so-called phenomenon of overtourism has emerged as a significant threat to the residents’ quality of life, and, consequently, the sustainability of Art Cites. This research aims to develop a management toolkit that assists site managers to control tourism flows in Art Cities and World Heritage Sites and promotes the residents’ quality of life. The research methodology was developed within the framework of the Atlas Project in 2019. In this project, five European Art Cities, including Florence, Edinburgh, Bordeaux, Porto, and Santiago de Compostela, discussed their common management challenges through the shared learning method. After developing selection criteria, the Atlas’ partners suggested a total of nine strategies as best practices for managing overtourism in Art Cities in multiple sections of accommodation policies, monitoring tactics, and promotional offerings. The Atlas project was conducted before the outbreak of the COVID-19 virus pandemic. Based on the current data, it is somehow uncertain when and how tourism activities will return to normal. The analysis of the Atlas findings also highlights some neglected dimensions in the current strategies in terms of environmental concerns, climate change impacts, crisis management, and cultural development plans, which require further research to boost the heritage planning process.
Visual Comfort in Modern University Classrooms
Authors: Chiou Yun-Shang , Saputro Satryo , Sari Dany Perwita
Published: May 2020

Universities are at the front line of promoting sustainability. The wellbeing of its students plays a key role in advancing such agendas. In the past decade, many university classrooms have been equipped with a projector; however, the lighting design of the classroom remains unchanged. This paper presents a visual comfort study of modern university classrooms by considering three working surfaces: the student’s desk, whiteboard, and projector screen. The study cross-examines the quality of the classroom lighting by high dynamic range image (HDRi) photography and the students’ well-being from user satisfaction surveys. Comparisons are organized based on the seating area of the student, the type of learning (text-based or image-based) in the classroom, and the lighting scene with and without a projector in use. The spot illuminance, luminance, HDRi spatial luminance distribution and the Unified Glare Rating (UGR) are the parameters used to describe lighting quality. This paper found that more than 70% of the respondents experienced some adverse physical symptoms, and nearly 50% felt that the lighting condition was not ideal for task performance. UGR indicated the presence of minor glare problems in whiteboard-based teaching scenarios, and daylight was too strong to be utilized. The results suggest that the lighting design needs to involve a luminance distribution minded approach for the students’ wellbeing in classroom learning.
Enhancing Marketing Performance Through Enterprise-Initiated Customer Engagement
Authors: Marolt Marjeta , Zimmermann Hans-Dieter , Pucihar Andreja
Published: May 2020

The exponential speed of technological advancements and the ever-changing needs of customers have changed the way enterprises engage with their customers. However, despite the increasing scholarly interest in the enterprise-initiated perspective of customer engagement (CE) in recent years, it remains unclear what drives enterprises to initiate customer engagement and how enterprise-initiated customer engagement enhances enterprise performance. Thus, the purpose of this study is to develop and evaluate a conceptual model that consists of drivers and outcomes of enterprise-initiated customer engagement. After developing a conceptual model based on previous conceptual approaches to customer engagement, a quantitative survey was undertaken to gather the data from business-to-customer micro, small, and medium-sized enterprises. The data were analyzed using the partial least square path modelling. The findings showed that external pressure and organizational readiness influence enterprise-initiated customer engagement. Enterprise-initiated customer engagement was also found to influence marketing performance. The empirical findings provide insights for managers that explain what drivers may influence enterprise-initiated customer engagement and what benefits they can expect. Overall, this research extends the understanding of the CE domain and provides additional insights for the drivers and outcomes of enterprise-initiated CE.
New Business Models Based on Multiple Value Creation for the Customer: A Case Study in the Chemical Industry
Authors: Šimberová Iveta , Kita Peter
Published: May 2020

The paper’s objective is to describe business models currently used in terms of sustainable multiple customer creation in the chemical industry in the Czech Republic, namely Section 20.1 in the CZ NACE (Classification of Economic Activities). The business models are described through a specified set of business model elements, which correspond with the presented theoretical bodies. The business models are also evaluated and benchmarked based on a custom indicator measuring business model novelty. The theoretical background of the research consists of three theoretical bodies: Sustainability, multiple customer value creation, and new business models. The research stems from the theoretical background and anticipates that the business model development dynamics drives companies to consider the reasons and conditions of their very existence. The Canvas business model serves as a visualization tool, as it is sufficiently comprehensive, analytical, flexible, and general. For this reason, it is appropriate for the research of new business models aimed at multiple value creation in any industry. Owing to the frequency of occurrence of elements in the fields of the canvas business model, it is possible to develop the majority and minority business model design representing the basis of the research.
Construction Method of a Guaranteed Grid Considering the Specific Recovery Process
Authors: Zhang Shengfeng , Zhao Jie , Weng Yixuan , Liu Dichen , Ma Weizhe , Ma Yuhui
Published: May 2020

For the planning of the guaranteed power grid, only the operation capacity of the target grid is considered. The recovery process and steps of the backbone grid are not considered enough, which leads to two defects: the minimum guaranteed power grid is not conducive to the unit recovery and the recovery time is too long. In this paper, a method of constructing the grid with the specific recovery process is proposed. Considering the influence of the grid structure and the position of the black start power supply on the recovery steps, the recovery success rate and the recovery time of the grid, the optimization of the grid structure of the guaranteed grid can meet the demand of power supply and at the same time make the recovery of the target grid less time-consuming and achieve a higher recovery success rate in the event of a blackout. In this method, two aspects are considered: the power failure recovery scenario in the recovery process of the target grid and the normal power supply scenario, reflecting the power supply performance after the recovery of the target grid. In the normal power supply scenario, a three-objective optimization model including power supply capacity, smooth transmission and safety margin is constructed, with power supply capacity and safe operation as constraints. In the scenario of power failure recovery, the process of power grid recovery and the mechanism affecting the success of recovery are analyzed to form the line recovery index. The Dijkstra algorithm is used to search for the optimal recovery path and calculate the recovery index, so as to reoptimize the backbone power grid. The validity of the method is verified by standard and practical examples.
The Ideal of Highly Mobile Prisoners. Re-Legitimating Prison through a New Paradox
Authors: Mincke Christophe
Published: May 2020

In our paper, we develop the hypothesis of a general call for high mobility and discuss the consequences of it regarding the legitimation of prison. First, we present the method we used for an analysis of the parliamentary documents of the Belgian penitentiary law. We then examine the contemporary social representations of mobility, looking for a definition of what is seen as being properly mobile, and show how intertwined social representations of space and time result in the prevalent vision of an inevitable and constant mobility. Next, we will thus discuss the importance of seeing mobility as much more than its material facet. Our following step will be to propose a formalization of the contemporary requisite for mobility. Through four imperatives (activity, activation, participation, adaptation), the mobilitarian ideal requires each person and organization to be constantly active, mobile, flexible, networking, etc. We argue that, today, we are all meant to be highly mobile. We will apply this theoretical framework to the legitimation of prison in the parliamentary documents of the 2005 Belgian Prison Act in which prison is open and porous, good inmates are described as dynamic individuals on the move, and the legitimate penitentiary system is a paradoxical mobilization system. We will conclude by discussing the need to reshape our vision of the prison, considering its apparently paradoxical relation with mobility.
The Jet-Disk Coupling of Seyfert Galaxies from a Complete Hard X-ray Sample
Authors: Liu Xiang , Chang Ning , Han Zhenhua , Wang Xin
Published: May 2020

We analyze the jet-disk coupling for different subsamples from a complete hard X-ray Seyfert sample to study the coupling indices and their relation to accretion rate. The results are: (1) the power-law coupling index ranges from nearly unity (linear correlation) for radio loud Seyferts to significantly less than unity for radio quiet ones. This decline trend of coupling index also holds from larger sources to compact ones; (2) the Seyferts with intermediate to high accretion rate (Eddington ratio λ ∼ 0.001 to 0.3) show a linear jet-disk coupling, but it shallows from near to super Eddington ( λ ∼ 0.3 to 10), and the former is more radio loud than the latter; (3) the Seyfert 1s are slightly steeper than the Seyfert 2s, in the jet-disk correlation. In the linear coupling regime, the ratio of jet efficiency to radiative efficiency ( η / ε ) is nearly invariant, but in low accretion or super accretion regime, η / ε varies with λ in our model. We note that a radio-active cycle of accretion-dominated active galactic nuclei would be: from a weaker jet-disk coupling in λ < 0 . 001 for low luminosity Seyferts, to a linear coupling in 0 . 001 < λ < 0 . 3 for radio-loud luminous Seyferts and powerful radio galaxies/quasars, and to a weaker coupling in 0 . 3 < λ < 10 ones.
The T4 TerL Prohead Packaging Motor Does Not Drive DNA Translocation by a Proposed Dehydration Mechanism
Authors: Black Lindsay W. , Yan Bingxue , Ray Krishanu
Published: May 2020

A “DNA crunching” linear motor mechanism that employs a grip-and-release transient spring like compression of B- to A-form DNA has been found in our previous studies. Our FRET measurements in vitro show a decrease in distance from TerL to portal during packaging; furthermore, there is a decrease in distance between closely positioned dye pairs in the Y-stem of translocating Y-DNA that conforms to B- and A- structure. In normal translocation into the prohead the TerL motor expels all B-form tightly binding YOYO-1 dye that cannot bind A-form. The TerL motor cannot package A-form dsRNA. Our work reported here shows that addition of helper B form DNA:DNA (D:D) 20mers allows increased packaging of heteroduplex A-form DNA:RNA 20mers (D:R), evidence for a B- to A-form spring motor pushing duplex nucleic acid. A-form DNA:RNA 25mers, 30mers, and 35mers alone are efficiently packaged into proheads by the TerL motor showing that a proposed hypothetical dehydration motor mechanism operating on duplex substrates does not provide the packaging motor force. Taken together with our previous studies showing TerL motor protein motion toward the portal during DNA packaging, our present studies of short D:D and D:R duplex nucleic acid substrates strongly supports our previous evidence that the protein motor pushes rather than pulls or dehydrates duplex substrates to provide the translocation into prohead packaging force.
Glucose-Regulated Protein 78 Interacts with Zika Virus Envelope Protein and Contributes to a Productive Infection
Authors: Royle Jamie , Ramírez-Santana Carolina , Akpunarlieva Snezhana , Donald Claire L. , Gestuveo Rommel J. , Anaya Juan-Manuel , Merits Andres , Burchmore Richard , Kohl Alain , Varjak Margus
Published: May 2020

Zika virus (ZIKV; Flaviviridae) is a mosquito-borne flavivirus shown to cause fetal abnormalities collectively known as congenital Zika syndrome and Guillain-Barré syndrome in recent outbreaks. Currently, there is no specific treatment or vaccine available, and more effort is needed to identify cellular factors in the viral life cycle. Here, we investigated interactors of ZIKV envelope (E) protein by combining protein pull-down with mass spectrometry. We found that E interacts with the endoplasmic reticulum (ER) resident chaperone, glucose regulated protein 78 (GRP78). Although other flaviviruses are known to co-opt ER resident proteins, including GRP78, to enhance viral infectivity, the role ER proteins play during the ZIKV life cycle is yet to be elucidated. We showed that GRP78 levels increased during ZIKV infection and localised to sites coincident with ZIKV E staining. Depletion of GRP78 using specific siRNAs significantly reduced reporter-virus luciferase readings, viral protein synthesis, and viral titres. Additionally, GRP78 depletion reduced the ability of ZIKV to disrupt host cell translation and altered the localisation of viral replication factories, though there was no effect on viral RNA synthesis. In summary, we showed GRP78 is a vital host-factor during ZIKV infection, which may be involved in the coordination of viral replication factories.
Potential Drugs Targeting Early Innate Immune Evasion of SARS-Coronavirus 2 via 2’-O-Methylation of Viral RNA
Authors: Encinar José Antonio , Menendez Javier A.
Published: May 2020

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causing the COVID-19 respiratory disease pandemic utilizes unique 2′-O-methyltransferase (2′-O-MTase) capping machinery to camouflage its RNA from innate immune recognition. The nsp16 catalytic subunit of the 2′-O-MTase is unusual in its requirement for a stimulatory subunit (nsp10) to catalyze the ribose 2′-O-methylation of the viral RNA cap. Here we provide a computational basis for drug repositioning or de novo drug development based on three differential traits of the intermolecular interactions of the SARS-CoV-2-specific nsp16/nsp10 heterodimer, namely: (1) the S-adenosyl-l-methionine-binding pocket of nsp16, (2) the unique “activating surface” between nsp16 and nsp10, and (3) the RNA-binding groove of nsp16. We employed ≈9000 U.S. Food and Drug Administration (FDA)-approved investigational and experimental drugs from the DrugBank repository for docking virtual screening. After molecular dynamics calculations of the stability of the binding modes of high-scoring nsp16/nsp10–drug complexes, we considered their pharmacological overlapping with functional modules of the virus–host interactome that is relevant to the viral lifecycle, and to the clinical features of COVID-19. Some of the predicted drugs (e.g., tegobuvir, sonidegib, siramesine, antrafenine, bemcentinib, itacitinib, or phthalocyanine) might be suitable for repurposing to pharmacologically reactivate innate immune restriction and antagonism of SARS-CoV-2 RNAs lacking 2′-O-methylation.
Key Players in HIV-1 Transcriptional Regulation: Targets for a Functional Cure
Authors: Mori Luisa , Valente Susana T.
Published: May 2020

HIV-1 establishes a life-long infection when proviral DNA integrates into the host genome. The provirus can then either actively transcribe RNA or enter a latent state, without viral production. The switch between these two states is governed in great part by the viral protein, Tat, which promotes RNA transcript elongation. Latency is also influenced by the availability of host transcription factors, integration site, and the surrounding chromatin environment. The latent reservoir is established in the first few days of infection and serves as the source of viral rebound upon treatment interruption. Despite effective suppression of HIV-1 replication by antiretroviral therapy (ART), to below the detection limit, ART is ineffective at reducing the latent reservoir size. Elimination of this reservoir has become a major goal of the HIV-1 cure field. However, aside from the ideal total HIV-1 eradication from the host genome, an HIV-1 remission or functional cure is probably more realistic. The “block-and-lock” approach aims at the transcriptional silencing of the viral reservoir, to render suppressed HIV-1 promoters extremely difficult to reactivate from latency. There are unfortunately no clinically available HIV-1 specific transcriptional inhibitors. Understanding the mechanisms that regulate latency is expected to provide novel targets to be explored in cure approaches.
Detection of Astrovirus in a Cow with Neurological Signs by Nanopore Technology, Italy
Authors: Zaccaria Guendalina , Lorusso Alessio , Hierweger Melanie M. , Malatesta Daniela , Defourny Sabrina VP , Ruggeri Franco , Cammà Cesare , Ricci Pasquale , Di Domenico Marco , Rinaldi Antonio , Decaro Nicola , D’Alterio Nicola , Petrini Antonio , Seuberlich Torsten , Marcacci Maurilia
Published: May 2020

In this study, starting from nucleic acids purified from the brain tissue, Nanopore technology was used to identify the etiological agent of severe neurological signs observed in a cow which was immediately slaughtered. Histological examination revealed acute non-suppurative encephalomyelitis affecting the brainstem, cerebrum, cerebellum, and medulla oblongata, while by using PCR-based assays, the nucleic acids of major agents for neurological signs were not detected. By using Nanopore technology, 151 sequence reads were assigned to Bovine Astrovirus (BoAstV). Real-time RT-PCR and in situ hybridization (ISH) confirmed the presence of viral RNA in the brain. Moreover, using the combination of fluorescent ISH and immunofluorescence (IF) techniques, it was possible to detect BoAstV RNA and antigens in the same cells, suggesting the active replication of the virus in infected neurons. The nearly whole genome of the occurring strain (BoAstV PE3373/2019/Italy), obtained by Illumina NextSeq 500, showed the highest nucleotide sequence identity (94.11%) with BoAstV CH13/NeuroS1 26,730 strain, an encephalitis-associated bovine astrovirus. Here, we provide further evidence of the role of AstV as a neurotropic agent. Considering that in a high proportion of non-suppurative encephalitis cases, which are mostly indicative of a viral infection, the etiologic agent remains unknown, our result underscores the value and versatility of Nanopore technology for a rapid diagnosis when the PCR-based algorithm gives negative results.
Evaluation of Varicella Immunity during Pregnancy in Apulia Region, Southern Italy
Authors: Trombetta Claudia M. , Montomoli Emanuele , Viviani Simonetta , Coluccio Rosa , Marchi Serena
Published: May 2020

Varicella is a highly contagious, infectious disease caused by the varicella-zoster virus. Those at higher risk of severe complications are immunocompromised individuals, adults, non-immune pregnant women, and newborns. According to the gestational time, when varicella-zoster virus infection is acquired during pregnancy, serious complications can potentially occur for both the woman and the fetus. The present study was conducted to assess the profile of varicella susceptibility in pregnant women in Apulia, a large region in Southern Italy, from 2016 to 2019. The data showed that pregnant women between the age of 15–24 and 40–49 years, the youngest and the oldest, respectively, are the most protected against varicella-zoster virus infection, exceeding the prevalence rate of 90%. Conversely, pregnant women between the age of 25 and 34 years seem to be the most vulnerable and the most at risk for acquiring varicella-zoster virus infection during pregnancy. Analysis of the immunity status against varicella should be introduced as a screening test before pregnancy, together with a strategic vaccination campaign targeting non-immune women of childbearing age, in order to reduce the risk of congenital and perinatal varicella.
Identification of Novel Adjuvants for Ebola Virus-Like Particle Vaccine
Authors: Feng Huapeng , Nakatsu Sumiho , Lopes Tiago Jose da Silva , Imai Masaki , Yamayoshi Seiya , Yamashita Makoto , Watanabe Tokiko , Kawaoka Yoshihiro
Published: May 2020

Ebola virus disease is a severe disease, often fatal, with a mortality rate of up to 90%. Presently, effective treatment and safe prevention options for Ebola virus disease are not available. Therefore, there is an urgent need to develop control measures to prevent or limit future Ebola virus outbreaks. Ebola virus protein-based virus-like particle (VLP) and inactivated whole virion vaccines have demonstrated efficacy in animal models, and the addition of appropriate adjuvants may provide additional benefits to these vaccines, including enhanced immune responses. In this study, we screened 24 compounds from injectable excipients approved for human use in Japan and identified six compounds that significantly enhanced the humoral response to Ebola VLP vaccine in a murine model. Our novel adjuvant candidates for Ebola VLP vaccine have already been demonstrated to be safe when administered intramuscularly or subcutaneously, and therefore, they are closer to clinical trials than adjuvants whose safety profiles are unknown.
Targeting Host Innate and Adaptive Immunity to Achieve the Functional Cure of Chronic Hepatitis B
Authors: Ezzikouri Sayeh , Hoque Kayesh Mohammad Enamul , Benjelloun Soumaya , Kohara Michinori , Tsukiyama-Kohara Kyoko
Published: May 2020

Despite the availability of an effective preventive vaccine for hepatitis B virus (HBV) for over 38 years, chronic HBV (CHB) infection remains a global health burden with around 257 million patients. The ideal treatment goal for CHB infection would be to achieve complete cure; however, current therapies such as peg-interferon and nucleos(t)ide analogs are unable to achieve the functional cure, the newly set target for HBV chronic infection. Considering the fact functional cure has been accepted as an endpoint in the treatment of chronic hepatitis B by scientific committee, the development of alternative therapeutic strategies is urgently needed to functionally cure CHB infection. A promising target for future therapeutic strategies is immune modulation to restore dysfunctional HBV-specific immunity. In this review, we provide an overview of the progress in alternative therapeutic strategies, including immune-based therapeutic approaches that enhance host innate and adaptive immunity to achieve and increase the functional cure from CHB infection.
Derivation of Geometrical Interdependencies between the Passenger Compartment and the Traction Battery Using Dimensional Chains
Authors: Nicoletti Lorenzo , Mirti Samuel , Schockenhoff Ferdinand , König Adrian , Lienkamp Markus
Published: May 2020

Dimensional chains are the basis for testing the feasibility of vehicle architectures in the early development phase since they allow for parametrical vehicle modeling. Parametrical modeling is employed in the early development of the vehicle in order to enable the estimation of the space available for powertrain components. For battery electric vehicles (BEVs), new dimensional chains have increased relevance because of the geometrical interdependencies between the traction battery and the passenger compartment. The passenger compartment and traction battery share the same position in the vehicle, i.e., between the axles, which leads to a conflict between these two components. Furthermore, the passenger compartment dimensions are needed to size components like heating, ventilation, and air conditioning (HVAC), the energy consumption of which in turn influences the required battery capacity. In order to describe these interdependencies, we identify a set of dimensional chains and derive a passenger compartment volume estimation model that can be employed in the early development phase of the vehicle design. We further analyze the single elements of the dimensional chain and present typical values for each element.
Universidad y proyectos de vinculación con la sociedad, un análisis técnico legal y su efecto en los procesos de aprendizajes
Authors: Tamayo Arellano Vicente Rodrigo , Taco Taco Carlos Wilfrido , Hallo Montesdeoca Danny Fabián , Fajardo Aguilar Graciela Maribel
Published: May 2020

En el presente estudio se plasman principalmente los procesos de vinculación que mantienen las instituciones de educación superior con su entorno o la sociedad donde mantengan un enfoque ya sea económico, social, por sector o educativo y está regido por las políticas, leyes o normativas a nivel universitario. Para llevar a cabo el presente trabajo de investigación se realizó una comparación de la situación interna de Ecuador, con otros países de Latinoamérica y Europa en las instituciones de educación superior, por ello se busca saber si los fundamentos técnicos legales aportan positiva o negativamente al proceso de aprendizaje mediante una revisión de tipo documental descriptiva. Esta se hizo por medio de búsqueda electrónica en libros, tesis, revistas, ponencias y publicaciones de congresos afines al tema, desde sus inicios e información relevante y actualizada. Una de las concluyentes es que una institución de educación superior pretende cumplir en su totalidad con la normativa, ya sea interna o externa, en relación a la vinculación con la sociedad, buscando así el aprendizaje bidireccional, es decir, tanto de docentes y alumnos, como también el transmitir conocimiento a una comunidad o sector beneficiario.
La administración de justicia indígena en Ecuador, un enfoque desde su cosmovisión
Authors: Garcia Belkis Alida
Published: May 2020

Este artículo tuvo como objetivo un análisis crítico sobre la administración de justicia indígena en Ecuador, desde la cosmovisión indígena. En otras palabras, interpretar cómo la esta se deriva de las costumbres, mitos y leyendas provenientes de todo un aprendizaje de sus ancestros. Por otro lado, busca contrastar cómo y cuáles son los principales problemas que se presentan entre la justicia indígena y la ordinaria. Sus penas y/o castigos, cosmogónicamente, el elemento justicia no puede ser otra cosa que el reflejo de todos estos usos y costumbres. Gracias a las enseñanzas de adultos mayores, padres y abuelos, se fue formando un paradigma de respeto de valores, principios éticos y armonía. La ley natural es ese conjunto de normas objetivas que rigen la naturaleza, independiente de la voluntad del hombre; como es la ley del día, de la lluvia, del viento, el ciclo de la vida: nacer, crecer, reproducir y volver dándose de esta forma una relación del hombre y la naturaleza, conservando el equilibrio natural. El presente trabajo aborda un ejemplo de problemática de la aplicación de justicia por parte de los pueblos indígenas ecuatorianos: non bis in ídem, que en español significa “no dos veces por lo mismo”, y que también es usada la forma ne bis in ídem.
Editorial
Authors: Piña Ferrer Lenys
Published: May 2020

Editorial
Cultura organizacional en docentes de educación básica
Authors: Eljuri Blanco Ana Cecilia , Villasmil Yánez Maydalí
Published: May 2020

La investigación tuvo por objetivo analizar la cultura organizacional en docentes de educación básica desde la perspectiva de la Escuela Comercial Nacional  Pedro Curiel Ramírez en el Municipio Miranda del estado Falcón, Venezuela. Se trabajó con un tipo descriptiva, el instrumento se le aplicó a 50 docentes de la institución quienes se encuentran distribuidos de la siguiente manera: 25 correspondientes a la primera etapa Robinsoniana y 25 pertenecientes a la etapa media profesional. En relación a los encuestados afirman que no existe en la institución un lenguaje  acorde a una institución educativa con un 24% acorde, un 78% no acorde a una institución educativa, así mismo se refleja en los resultados que no se integra al personal docente a la toma de decisiones institucionales, con un 79%   un 21% manifestaron que si se toma en cuenta al personal para la toma de decisiones.
Docentes y padres en el proceso de aprendizaje de los estudiantes
Authors: Páez Andreína
Published: May 2020

La investigación tuvo como propósito principal fortalecer el trabajo del docente y la participación de los padres en el proceso de aprendizaje de los estudiantes de la Escuela Bolivariana “Alberto Ravell” de la Ciénaga, municipio Zamora, Estado Falcón. Metodológicamente se encuentra enmarcada bajo los postulados del paradigma sociocrítico, Una vez aplicado y ejecutado el plan de acción se evaluaron las acciones realizadas, favoreciendo la motivación, el dinamismo y la integración del colectivo docente y de los padres, para transformar la realidad existente en los diferentes ambientes de aprendizaje. El  proceso de enseñanza y aprendizaje es pasivo, sin motivación por parte de los docentes quienes no implementan otros mecanismos para fortalecer este proceso, particularmente buscar la manera de integrar a los padres y representantes, ya que se corroboró la falta el acompañamiento de los mismos en el proceso de formación de sus hijos.
Editorial
Authors: Antonio Pirona Jesús
Published: May 2020

Editorial
Melanoma Nodular Amelanótico
Authors: Santos Silva Thadeu , Rebouças de Araujo Luciana , Baptista de Almeida Faro Gustavo , Rezende Paiva Geise
Published: May 2020

Resumo do Artigo: Thadeu Santos Silva, Luciana Rebouças de Araujo, Gustavo Baptista de Almeida Faro. Nodular amelanotic melanoma. Letters. An. Bras. Dermatol. vol.94 no.4 Rio de Janeiro July/Aug. 2019 Epub Oct 17, 2019. https://doi.org/10.1590/abd1806-4841.20198453.
Financial support of entrepreneurship development in Ukraine: institutional component
Authors: Spyak Halyna , Fastovets Mykola
Published: May 2020

Introduction. Entrepreneurship development is particularly important in the context of the crisis of the domestic economy, the uncertainty of the state economic policy, and the increased impact of external challenges and threats. In view of the current state of the market and the risks involved in providing financial support to the development of entrepreneurship in Ukraine, the importance of research into the institutional component of its functioning is increasing. Under these conditions, the issues of implementation of a systematic approach to the development and implementation of the state policy of financial support of business structures, as well as determining the place and role of commercial institutions, in particular banks, in the process of optimizing the financial security of business entities become highly relevant. Purpose. Research of the institutional component of financial support for the development of entrepreneurship in Ukraine, determining the place and role of state and commercial institutions in its implementation, outlining the directions of intensifying their influence on the financial aspects of entrepreneurship in modern conditions. Results. The composition and structure of the institutional environment of financial support for the development of entrepreneurship are determined. The activity of individual market institutions in the context of the implementation of projects and programs of financial support to entrepreneurship in Ukraine have been analyzed. Emphasis is placed on the need to ensure a systematic approach to the implementation of state programs of financial support for entrepreneurship. Positive aspects of the activity of financial-credit institutions and banks, in particular, in the context of financial support of business structures were identified as well as the risks and limitations inherent in them. Such restrictions are due to the current state of the domestic economy and monetary sector, lack of clear business policy, high level of credit risks, low ratings of borrowers, problems of the banking sector itself, etc. In view of this, at this stage of development of the domestic financial market financial and credit institutions have limited influence on the formation of external sources of financial resources of business entities. Directions of optimization of information and consulting activity of market institutions have been offered, aimed at increasing the efficiency of implementation of projects and programs of financial support of business structures in order to strengthen their influence on regional, sectoral and macroeconomic parameters of economic growth.
GAMBARAN BALITA STUNTING BERDASARKAN KARAKTERISTIK DEMOGRAFI IBU DI WILAYAH KERJA PUSKESMAS PUNDONG BANTUL YOGYAKARTA
Authors: Suryati Suryati , Supriyadi Supriyadi , Oktavianto Eka
Published: May 2020

Background: Stunting is still a children’s nutrition problem at this time. The percentage of cases of stunting children’s is increasing. Stunting can affect children in the long run, that is, disrupt health, education and productivity in the future. Maternal demographic factors are thought to be a factor that plays a role in the occurrence of stunting children.Purpose: provide an overview and discussion of stunting based on maternal demographic characteristics.Method: This research is a non-experimental research with an observational descriptive approach. Data was collected using a demographic characteristics questionnaire. The sample in this study was 90 stunting toddlers in the working area of the Pundong Community Health Center, Bantul, Yogyakarta. The sampling technique in this study uses simple random sampling. Data analysis uses percentage formulasResults: in stunting toddlers, the majority of maternal’s aged less than 30 years were 52 people (58%), the majority of maternal’s' education was low education (junior high school and elemtary school) which was 60 people (66%), the number of family members was more than 4 people were as many as 64 respondents (66.7%), the majority of mother who did not work were 52 people (57.8%), had incomes that were less than district minimum wage, which were 63 people (70%).Conclusion: there are several parental demographic factors that have a role in the occurrence of stunting under five, such as: maternal’s age, level of education, number of family members, employment status, and family income.
Pengenalan Pola Daun untuk Membedakan Tanaman Padi dan Gulma Menggunakan Metode Principal Components Analysis (PCA) dan Extreme Learning Machine (ELM)
Authors: Ahmad Izzuddin  , M. Rizal Wahyudi
Published: May 2020

Perkembangan ilmu pengetahuan serta pesatnya teknologi memberikan banyak manfaat bagi manusia dalam menjalankan aktifitasnya. Pemanfaatan ilmu pengetahuan dan teknologi tersebut di berbagai bidang termasuk di bidang pertanian. Pengembangan potensi pertanian suatu daerah dapat dioptimalkan melalui perkembangan ilmu pengetahuan dan teknologi itu sendiri. Salah satunya dengan pengenalan pola citra digital. Pengenalan pola bertujuan menentukan kelompok atau kategori pola berdasarkan ciri-ciri yang dimiliki oleh pola tersebut. Dengan kata lain, pengenalan pola membedakan suatu objek dengan objek lain. Dengan menggunakan metode ektraksi ciri Principal Component Analysis dan metode klasifikasi Extreme Learning Machine penulis melakukan penelitian untuk membedakan tanaman padi dan tanaman gulma. Implementasi PCA dan ELM mampu membedakan tanaman gulma dengan padi (Oryza sativa L) dalam hal ini gulma yang digunakan adalah jawan (Echinochloa cruss-galli) dan kremah (Alternanthera sessilis). Berdasarkan hasil pengujian yang dilakukan 8 kali running dengan merubah jumlah hidden neuron diperoleh nilai akurasi paling tinggi sebesar 91,67 % dengan menggunakan 10, 15, 30, 35, 40 hidden neuron, sedangkan untuk nilai akurasi paling rendah sebesar 58% dengan jumlah hidden neuron 5. Waktu yang dibutuhkan ELM untuk melakukan pelatihan dan pengujian sangat singkat 0.374 detik dan 0.500 detik pengukuran dilakukan dimulai dari running program sampai proses running program selesai.
Mutual Intercultural Relations among University Students in Canada
Authors: Gui Yongxia , Safdar Saba , Berry John
Published: May 2020

Over 304,000 international students studied in Canadian universities in 2013 (CIC, 2014). In addition to their academic success, one important feature of their stay in Canada is the quality of the intercultural relations, and the adaptations they make during their stay. The present study sought to understand the intercultural relations, acculturation and adaptation of both international students and Canadian students. Fifty-seven international (all from China) and 68 domestic students were drawn from several Canadian universities. Cluster analysis generated two clusters for international students (integration and diffuse) and two for Canadian students (multiculturalism and melting pot). International students in the integration cluster were more tolerant and better adapted than those in the diffuse cluster. Similarly, Canadian students in the multiculturalism cluster were also more tolerant and better adapted than those in the melting pot cluster. Implications of these findings for preparing international and Canadian students for their intercultural encounters were discussed.
Study Abroad in a Time of Terror; U.S. Student Experiences in Brussels
Authors: Gleye Paul H.
Published: May 2020

When terrorists bombed the Brussels airport and metro in March 2016, seventeen U.S. university students were in Brussels, halfway through a faculty-led semester abroad program.  Although the students were unharmed, they encountered deep concern for their safety, and the future of study abroad programs in Brussels was immediately put into question.  Two days after the attacks they recorded their reactions to the bombings, to the aftermath they experienced in Brussels, and to a question as to whether the study abroad program should be terminated.  This essay records, in the students’ own words, their responses to the horrific and unimaginable events, and it records the students’ views on the future of study abroad programs in a time of uncertainty.  The students unanimously expressed resolve that despite the trauma they had no regrets about participating in the study abroad program and that such tragic events should not lead to a withdrawal of study abroad opportunities in the future.  The essay concludes with recommendations for preparing students for uncertainty and providing support in times of need.
The Impact of Basel III Capital Regulation on Profitability: A Hybrid Model
Authors: ALFOUHAILI NADIM
Published: May 2020

This research examined the impact of Basel III capital regulation (BCR) on profitability (P) using a sample of 25 commercial banks in Lebanon over the period 2012–2017. BCR is measured using the capital adequacy ratio (CAR) and the common equity tier one ratio (CET1 ratio), P is measured using two ratios: ROAA and ROAE. To analyze the data, we constructed a hybrid model based on three statistical approaches. First, we modelled the dual impact of BCR and P using probabilistic inference in the framework of Bayesian Belief Network formalism (BBN). Second, to highlight more about the correlation between BCR and P, we used the Spearman correlation test as a nonparametric approach. Third, to study the simultaneous effect of the BCR ratio on Profitability we apply multivariate regression analysis. By analyzing the probabilistic inference for the first approach, we concluded that there is an effect from BCR on P. When we investigated more if this effect is significance using the Spearman correlation test and the multivariate regression analysis, we concluded that that the impact of BCR on P is only found between CAR and ROAA and this regression relationship is weak because only 24.3% of the changes in ROAA variance is explained by CAR.
Local subestimates of solutions to double-phase parabolic equations via nonlinear parabolic potentials
Authors: Buryachenko Kateryna
Published: May 2020

For parabolic equations with nonstandard growth conditions, we prove local boundedness of weak solutions in terms of nonlinear parabolic potentials of the right-hand side of the equation.
Estimates of the inner radii of non-overlapping domains
Authors: Denega Iryna
Published: May 2020

Some extremal problems of the geometric theory of functions of a complex variable related to the estimates of functionals defined on systems of non-overlapping domains are considered. Till now, many such problems have not been solved, though some partial solutions are available. In the paper, the improved method is proposed for solving the problems on extremal decomposition of the complex plane. The main results generalize and strengthen some known results in the theory of non-overlapping domains with free poles to the case of an arbitrary arrangement of systems of points on the complex plane.
ANALISIS DAN DESAIN SISTEM INFORMASI BIAYA PEMASARAN MARKETING PADA PT. YGI AREA SUMATERA
Authors: Muryono Tupan Tri
Published: May 2020

In English :

Technology that combines computer technology and telecommunications technology has changed the way of life of individuals and organizations in carrying out business activities or carrying out daily activities. The ability of communication between one organization and other organizations in different places (separated at great distances) is one of the characteristics of the coming era of globalization. The problems that exist in PT. YGI is the absence of a system that can provide marketing information to consumers. This research was conducted to gather information about marketing marketing costs, promotions, rebates, general costs and costs of branch operating funds to make decisions that are more effective, efficient, and easier for management . The author uses the method of collecting data through observation and interviews and based on theories derived from several books or journals related to the method of system design using object-oriented design methods. The results of the design and development of marketing information system marketing analysis design at PT. YGI Area Sumatra can provide solutions to problems faced in the product sales process as well as product marketing solutions for companies so that ordering products from customers increases and relationships increase. With the design of marketing information systems marketing costs can develop and publish products properly and can be seen by consumers as clearly as possible.

In Indonesian :

Teknologi yang menggabungkan teknologi komputer dan teknologi telekomunikasi ini telah mengubah cara hidup individu maupun organisasi dalam menjalankan aktivitas bisnisnya atau menjalankan kegiatan sehari-hari. Kemampuan komunikasi antara satu organisasi dengan organisas lainnya di tempat yang berbeda (terpisah pada jarak yang jauh) merupakan salah satu ciri era globalisasi mendatang. Permasalahan yang ada pada PT. YGI ialah belum adanya suatu sistem yang dapat memberikan informasi pemasaran kepada konsumen. Penelitian ini dilakukan untuk mengumpulkan informasi mengenai biaya pemasaran marketing, promosi, rabat, biaya umr dan biaya dana operasional cabang untuk membuat keputusan yang lebih efektif, efisien, dan lebih mudah bagi manajemen. Penulis menggunakan metode pengumpulan data dengan observasi dan wawancara serta berdasarkan teori yang berasal dari beberapa buku atau jurnal terkait dan untuk metode perancangan sistem menggunakan metode desain berorientasi objek. Hasil dari perancangan dan pembangunan analisa desain sistem informasi pemasaran marketing pada PT. YGI Area Sumatera dapat memberikan solusi terhadap permasalahan yang dihadapi dalam proses penjualan produk serta sebagai solusi atas pemasaran produk bagi perusahaan sehingga pemesanan produk dari customer dapat meningkat dan bertambahnya relasi. Dengan adanya desain sistem informasi biaya pemasaran marketing dapat mengembangkan dan mempublikasikan produk dengan baik dan dapat dilihat oleh konsumen dengan sejelas mungkin.