bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation on keyhole mode fiber laser welding of SS 316 in a self-protected atmosphere
Authors: Chowdhury Sohini , Nirsanametla Yadaiah , Manapuram Muralidhar
Published: July 2019

This work focuses on examining the influence of welding parameters under different welding atmospheres and evaluation of keyhole profile during fiber laser welding operation. The experiments are carried out in two different welding atmospheres, namely self-protected atmosphere of Ar gas and open atmospheric conditions. The effect of these two atmospheric conditions on weld profile formation and dimensions, and microstructural evolution for SS 316 plates are examined. In addition, the keyhole profile is evaluated by using a semi-analytical mathematical model, a point-by-point energy balance determination at the keyhole wall, which is mapped with experimentally measured weld macrographs for similar welding conditions. It has been determined that the weld quality is profound in the case of a self-protected atmosphere with respect to aspect ratio, weld defects, and microstructural characterization. Moreover, better weld bead profile and cleaner weld seam on the upper surface is determined in samples welded in a self-protected atmosphere.
Interpersonal entrainment in Indian instrumental music performance: Synchronization and movement coordination relate to tempo, dynamics, metrical and cadential structure
Authors: Clayton Martin , Jakubowski Kelly , Eerola Tuomas
Published: July 2019

Two complementary aspects of interpersonal entrainment – synchronization and movement coordination – are explored in North Indian classical instrumental music, in the auditory and visual domains respectively. Sensorimotor synchronization (SMS) is explored by analysing pairwise asynchronies between the event onsets of instrumental soloists and their tabla accompanists, and the variability of asynchrony by factors including tempo, dynamic level and metrical position is explored. Movement coordination is quantified using cross wavelet transform (CWT) analysis of upper body movement data, and differences in CWT Energy are investigated in relation to the metrical and cadential structures of the music. The analysis demonstrates that SMS within this corpus varies significantly with tempo, event density, peak levels and leadership. Effects of metrical position on pairwise asynchrony are small and offer little support for the hypothesis of lower variability in synchronization on strong metrical positions; a larger difference was found at cadential downbeats, which show increased melody lead. Movement coordination is greater at metrical boundaries than elsewhere, and most strikingly is greater at cadential than at other metrical downbeats. The implications of these findings for understanding performer coordination are discussed in relation to ethnographic research on the genre.
Once more, with feeling: Conductors’ use of assessments and directives to provide feedback in choir rehearsals
Authors: Emerson Kathryn , Williamson Victoria , Wilkinson Ray
Published: July 2019

In this article Conversation Analysis is used to explore the way that conductors give feedback in choir rehearsals through the use of assessments and directives. Assessments and directives have previously been investigated in some forms of music teaching and rehearsing, although not in choir rehearsals. There is also a paucity of research on the methods by which a conductor may give feedback following an episode of singing by the choir. This analysis is based on 19 hours of choir rehearsal data, involving eight choirs and nine conductors. We show that conductors’ feedback turns typically consist of two particular communicative behaviours: assessments and directives, either occurring singly or in various combinations. Assessments explicitly evaluate (positively or negatively) the just-produced singing of the choir, and directives explicitly tell the choir something about how members should sing in the future. However, the data reveal that assessments can also function implicitly to direct how the choir should sing, and directives can implicitly evaluate singing. Assessments and directives can be done in depicted forms (e.g., using sung vocalisations and gestures), as well as verbal descriptive forms. These findings highlight the distinctive ways that conductors produce feedback within rehearsals and some of the particular inferences that choir members must draw on to understand this feedback, as well as how change and improvement in the choir’s singing may be affected on a turn-by-turn basis.
The effect of (a)synchronous music on runners’ lower leg impact loading
Authors: Lorenzoni Valerio , De Bie Tijl , Marchant Thierry , Van Dyck Edith , Leman Marc
Published: July 2019

Running with musical accompaniment is becoming increasingly popular and several pieces of software have been developed that match the music tempo to the exerciser’s running cadence, that is, foot strikes per minute. Synchronizing music with running cadence has been shown to affect several aspects of performance output and perception. The purpose of this study was to investigate the effect of synchronous music on runners’ foot impact loading. This represents the ground reaction force on the runner’s lower leg when the foot impacts the ground and is an important parameter for the prevention of tibial fracture injuries. Twenty-eight participants ran five times for three minutes and 30 seconds with a short break between each run. During the first 30 seconds of each running sequence, participants ran at a self-paced tempo without musical accompaniment, and running speed and cadence were measured. Subsequently, they were requested to keep their reference speed constant for the following three minutes, with the help of three monitoring screens placed along the track. During this part of the experiment, the music was either absent ( No Music), matched to the runner’s cadence ( Tempo-entrained Sync), phase-locked with foot strikes ( Phase-locked Sync), or played at a tempo 30% slower ( Minus 30%) or faster ( Plus 30%) than the initially measured running cadence. No significant differences between synchronous and asynchronous music were retrieved for impact loading. However, a non-negligible average increase of impact level could be observed for running sessions with music compared to running in silence. These findings might be especially relevant for treatment purposes, such as exercise prescription and gait retraining, and should be taken into account when designing musical (re-)training programmes.
Aesthetic empowerment through music
Authors: Brattico Elvira , Varankaitė Ulrika
Published: July 2019

This article describes how aesthetic enjoyment accompanying musical activities can empower individuals in health and disease. First, we explain the biological determinants of music enjoyment and how they can be studied. In doing so, we distinguish between core sensory pleasure and conscious liking, and we illustrate their respective contributions to aesthetic appreciation and expressive interaction with music. Second, we review findings illustrating the long-term impact of listening to favourite music on the brains of healthy musicians as well as on the brains and behaviour of individuals with pathological symptoms. Based on these findings, we propose a set of putative neural mechanisms underlying aesthetic empowerment through music. We also emphasize the importance of considering individual differences in sensitivity to aesthetic experiences of music, as evidenced, for instance, by neuroimaging and imaging genetics studies, drawing the connections between dopamine neurotransmission and dopaminergic genes with the reactivity of music–brain functions.
Shear actuation mechanism and shear-based actuation capability of an obliquely reinforced piezoelectric fibre composite in active control of annular plates
Authors: Dubey Manish Kumar , Panda Satyajit
Published: July 2019

In this work, the mechanism of shear actuation and the shear mode actuation capability of an obliquely reinforced piezoelectric fibre composite are investigated in active control of annular plates. This piezoelectric fibre composite is capable of providing extensional and shear actuation forces in a transverse plane of its Cartesian material coordinate system, and these actuation forces are utilized for shear-based actuation of an annular plate by embedding the piezoelectric fibre composite patches at the core of the plate. First, the mechanism of shear actuation of the annular sandwich plate is analysed, and it mainly reveals an adverse effect of the coupling between the transverse normal strain and shear stresses on the shear actuation forces, even though a good shear-actuated bending deformation of the annular plate is observed. So, next, the effectiveness of the piezoelectric fibre composite patches in shear mode active control of flexural vibration of the annular sandwich plate is investigated, where a shear-based feedback control arrangement is proposed for effective active control of the plate according to the velocity feedback control law. The analysis reveals an indicative shear actuation capability of this obliquely reinforced piezoelectric fibre composite, and thus it may be a potential material for shear-based active control of vibration of annular plates.
The statistical analysis of the dynamic performance of a gear system considering random manufacturing errors under different levels of machining precision
Authors: Guo Fang , Fang Zongde
Published: July 2019

Gear manufacturing error is one of the main sources of vibration and noise in gears; its influence on the dynamic transmission behaviour of gear systems is a research hotspot. In the current study on the effect of the manufacturing errors, the processing methods of the errors are mostly rough or hypothetical, so the analysis results cannot provide high reference value. This paper proposes a distinctive method to analyse the vibration response of helical gears in the presence of random manufacturing errors and modifications. The presented study performs tooth contact analysis (TCA) with the real tooth surface containing the random tooth profile error and the modification and performs loaded tooth contact analysis (LTCA) based on the superposition of the random pitch error and the initial gap between mating teeth obtained by TCA. Furthermore, the dynamic excitations, including time-varying mesh stiffness and meshing impact, are computed using the above-mentioned TCA and LTCA. The processing method for the manufacturing errors in this paper is reasonable and close to the actual situation of gear engagement. Using this proposed method, statistical analysis was carried out under machining accuracy grades 5, 6 and 7 to show the effect of the different distributions of random manufacturing errors on the gear vibration. The analysis results are of practical significance and provide references for the design and vibration control of gear drive systems.
Novel missense alleles of SIGMAR1 as tools to understand emerin-dependent gene silencing in response to cocaine
Authors: Arun Adith S , Eddings Chelsy R , Wilson Katherine L
Published: July 2019

Sigma-1 receptor (Sigma1R; SIGMAR1), an integral membrane protein of the endoplasmic reticulum and nuclear envelope, has a hydrophobic drug-binding pocket that binds with high affinity to addictive drugs (cocaine, methamphetamine) and therapeutics used to treat a wide spectrum of neurological disorders. Cocaine enhances Sigma1R association with three nuclear lamina proteins (emerin, lamin A/C, BANF1), causing Sigma1R-dependent and emerin-dependent recruitment and transcriptional repression of a gene, MAOB1, involved in dopamine removal from neural synapses. The mechanism of Sigma1R association with emerin and the molecular impact of cocaine on their association are unknown. Mutations in Sigma1R, as a proposed regulator or mis-regulator of the nuclear lamina, have the potential to alter nuclear lamina function in brain or other tissues. We examined the frequency of SIGMAR1 missense alleles among 60,706 unrelated individuals in the ExAC database. We identified two novel SIGMAR1 missense variants of particular interest due to their frequency and potential to impact molecular association with emerin or other nuclear lamina proteins. Variant p.Q2P was widespread in ExAC (overall allele frequency 18.4%) with broad ethnic distribution among non-Finnish Europeans, Africans, South Asians, Latinx (allele frequencies ∼15% to 23%), and East Asians (∼38%). The p.R208W allele was identified in ∼0.78% of individuals overall with enrichment in Africans, Latinx, and East Asians (∼1.9–2.9%). These and other novel Sigma1R variants provide tools for future studies to determine the molecular basis of Sigma1R association with emerin and the mechanism of nuclear lamina misregulation by cocaine and potentially other Sigma1R agonists.

Impact statement

The Sigma-1 Receptor (Sigma1R; SIGMAR1) binds neuroactive drugs—both therapeutic and addictive—and associates with the nuclear membrane protein emerin and its partners lamin A/C and BANF1 in response to cocaine, through unknown mechanisms. We identified two novel SIGMAR1 missense variants of special interest due to their prevalence in human populations and their potential to perturb Sigma1R function at the nuclear envelope. Despite its importance in physiology and pharmacology, many aspects of Sigma1R including its membrane topology are unclear. Our findings lay the foundation for future molecular studies to understand how Sigma1R associates with emerin, lamin A/C, and BANF1 and manipulates their activity in response to agonist.
Wearable resistance acutely enhances club head speed in skilled female golfers
Authors: Macadam Paul , Chau Anita , Cronin John
Published: July 2019

Golf is a skill-based sport which requires optimal swing mechanics to improve golf performance. As practitioners seek training methods to improve swing kinetics without compromising swing kinematics, loading through wearable resistance is one training modality which enables the golf swing to be performed in an overloaded manner. The purpose of this research therefore was to explore the acute effects of wearable resistance on golf swing performance measures. A randomised cross-over design was used with five skilled female golfers (22.0 ± 2.5 years, 163.1 ± 3.3 cm, 57.1 ± 3.4 kg and handicap 4 ± 1.2) who performed a series of golf shots with and without wearable resistance of 1.6 kg (∼2.8% body mass) attached laterally to the posterior trail side of the body. Flightscope launch monitor and force plate technology were used to quantify changes in club head speed and ground reaction forces. Using a paired t-test used for statistical analysis, significant ( p < 0.05) acute increases were found in club head speed (3.5%, p = 0.03), relative vertical ground reaction forces (11.4%, lead side, p = 0.01) and relative mediolateral ground reaction forces (7.1%, trail side, p = 0.03) with wearable resistance as compared to the unloaded condition. Wearable resistance enables a player to perform golf shots in an overloaded manner resulting in significant improvements in club head speed. Future research is required to assess the long-term adaptations to this form of loading on golf swing performance.
Estimation of the depth of investigation in the magnetotelluric method from the phase
Authors: Borah Ujjal K. , Patro Prasanta K.
Published: July 2019

Proper computation for depth of investigation (DOI) of the magnetotelluric (MT) method is vital because the standard approximate depth transforms provide the depth corresponds to the interpreted conductivities instead of the actual DOI of MT. Previous works on DOI estimation of the MT method are based on 1D inversion. Although the previous works are significant, the methods of DOI calculation are lengthy and affected by non-uniqueness of inverse modeling. Therefore, to overcome these problems, we developed a simple and direct approach of DOI computation for the MT method using phase, which applies to a layered earth. For this purpose, we calculate the instantaneous phases of electric and magnetic fields, which correspond to the minimum evaluation frequency using the solution of the 1D electromagnetic (EM) diffusion equation and instrument sensitivity. From the calculated instantaneous phases, we derive an expression that connects the phase-lag between the electric and magnetic fields at the minimum evaluation frequency to its corresponding DOI. To examine the effectiveness of our method, we applied the new approach to 1D synthetic and field data and compared the calculated DOIs with the DOIs obtained from a previous method. We determine that our new approach is faster in computation and overcomes the effect of non-uniqueness of inverse modeling, unlike the previous methods.
An efficient vector elastic reverse time migration method in the hybrid time and frequency domain for anisotropic media
Authors: Gao Kai , Huang Lianjie
Published: July 2019

Vector elastic reverse time migration (ERTM) produces subsurface elastic images with correct polarities using multicomponent seismic data. However, the decomposition of elastic wavefields into vector P- and S-wavefields is computationally expensive, particularly in heterogeneous and complex anisotropic media. We have developed a computationally efficient vector ERTM method in the hybrid time and frequency domain by combining three existing techniques. Rather than decomposing elastic wavefields into vector qP- and qS-wavefields during time-domain wavefield propagation, we conduct the wavefield decomposition in the frequency domain for several selected frequencies. In general, the number of selected frequencies needed for migration imaging is much smaller than the number of time steps during forward and backward wavefield propagation, leading to greatly reduced computational costs associated with the qP-/qS-wavefield vector separation in complex heterogeneous anisotropic media. We further combine an implicit directional wavefield separation into the vector ERTM to enhance the image quality. The numerical results demonstrate that our method produces high-quality elastic-wave migration images with notably reduced computational costs compared to the conventional vector ERTM method.
Clinical Work Intensity Among Medical Oncologists Practicing in National Community Oncology Research Program Community Sites
Authors: Hudson Matthew F. , O’Rourke Mark A. , Blackhurst Dawn W. , Caldwell Jennifer , Horner Ronnie D.
Published: July 2019

PURPOSE:

This study (1) assesses the level of clinical work intensity medical oncologists and oncologic nurse practitioners experience providing care and (2) identifies patient, provider, and practice factors mediating intensity.

PATIENTS AND METHODS:

Seventeen medical oncologists (12 physicians and five nurse practitioners) from five national sites national reported on the level of work intensity associated with 339 patient visits. Data collection at each site occurred over a 2- to 6 week period; for each provider, five visits were randomly selected from each of 4 randomly selected clinic days, yielding 20 visits per provider. Intensity was measured by the NASA–Task Load Index. Patient and visit characteristics were abstracted from the medical record; provider characteristics were self-reported by questionnaire.

RESULTS:

Clinical work intensity increased monotonically with level of service and was greatest when the visit involved discussion of either chemotherapy or terminal prognosis. Provider characteristics (including age, sex, and years of experience) were unrelated to intensity. Dimensions of work intensity that correlated directly with level of service included mental, physical, and temporal demand; effort; frustration; and stress. Perceptions of performance and of satisfaction with the visit were unrelated to level of service. Visits related to chemotherapy had greater mental, physical, and temporal demand, and effort, but worse perception of performance. When the visit involved a discussion of a terminal prognosis, greater intensity was reflected in all dimensions; stress was also greater, whereas visit satisfaction was significantly lower.

CONCLUSION:

Clinical work intensity increases with level of service provided and is greater for visits involving discussion of either terminal prognosis or chemotherapy.
PLIN2 Functions as a Novel Link between Progesterone Signaling and Metabolism in Uterine Leiomyoma Cells
Authors: Okeigwe Ijeoma , Bulun Serdar , Liu Shimeng , Rademaker Alfred W , Coon V John S , Kujawa Stacy , Robins Jared , Yin Ping
Published: July 2019

Context

Uterine leiomyoma (fibroids) are the most common tumors in women. Recently, perilipin-2 (PLIN2) was identified as a critical target gene of the progesterone receptor; however, its function in the pathogenesis of fibroids is unknown.

Objective

To determine the function of PLIN2 in leiomyoma cells

Design

Tissue and primary cells from leiomyoma and myometrium were analyzed. PLIN2 function in leiomyoma was assessed using siRNA. RNA-sequencing was performed to identify genome-wide effects of PLIN2 depletion. Metabolic activity was measured using the Seahorse XF96 Analyzer. Real-time qPCR and immunoblotting were also performed.

Setting

Laboratory

Patients or Other Participants

. 41 premenopausal women undergoing surgery for fibroids

Intervention(s)

None

Main Outcome Measure(s)

Gene expression, oxygen consumption rate (OCR), extracellular acidification rate (ECAR), and cell proliferation

Results

PLIN2 gene expression was 2.4-fold lower in leiomyoma compared to adjacent myometrium, suggesting a link between PLIN2 deficiency and fibroids. 3877 genes were differentially expressed after PLIN2 knockdown. Gene Ontology analysis identified metabolism as the second highest biological process affected by PLIN2 depletion (P=1.6E-10). OCR (mitochondrial respiration) and ECAR (glycolysis) were significantly upregulated after PLIN2 knockdown; PLIN2 depleted cells had greater basal metabolic activity (P<.0001) and a higher metabolic stress response (P<.0001). Cell proliferation was also significantly increased after PLIN2 knockdown (P<.05).

Conclusions

PLIN2 depletion increases mitochondrial respiration and glycolysis, suggesting that PLIN2 is a critical regulator of metabolic function in leiomyoma cells. PLIN2 deficiency also reprograms leiomyoma cells to a pro-proliferative phenotype. These findings introduce metabolomics as a novel area to explore to better understand leiomyoma tumorigenesis.
Challenges to the performance of current HIV diagnostic assays and the need for centralized specimen archives: a review of the Consortium for the Evaluation and Performance of HIV Incidence Assays (CEPHIA) repository
Authors: Facente Shelley N. , Busch Michael P. , Grebe Eduard , Pilcher Christopher D. , Welte Alex , Rice Brian , Murphy Gary
Published: July 2019

Background: New challenges for diagnosis of HIV infection abound, including the impact on key viral and immunological markers of HIV vaccine studies, pre-exposure prophylaxis usage and breakthrough infections, and very early initiation of anti-retroviral treatment. These challenges impact the performance of current diagnostic assays, and require suitable specimens for development and evaluation. In this article we review and describe an archive developed by the Consortium for the Evaluation and Performance of HIV Incidence Assays (CEPHIA), in order to identify the critical features required to create a centralized specimen archive to support these current and future developments.

Review and Findings: We review and describe the CEPHIA repository, a large, consolidated repository comprised of over 31,000 highly-selected plasma samples and other body fluid specimen types, with over 50 purposely designed specimen panels distributed to 19 groups since 2012. The CEPHIA repository provided financial return on investment, supported the standardization of HIV incidence assays, and informed guidance and standards set by the World Health Organization and UNAIDS. Unified data from extensively characterized specimens has allowed this resource to support biomarker discovery, assay optimization, and development of new strategies for estimating duration of HIV infection. Critical features of a high-value repository include 1) extensively-characterized samples, 2) high-quality clinical background data, 3) multiple collaborations facilitating ongoing sample replenishment, and 4) sustained history of high-level specimen utilization.

Conclusion: With strong governance and leadership, a large consolidated archive of samples from multiple studies provides investigators and assay developers with easy access to diverse samples designed to address challenges associated with HIV diagnosis, helping to enable improvements to HIV diagnostic assays and ultimately elimination of HIV. Its creation and ongoing utilization should compel funders, institutions and researchers to address and improve upon current approaches to sharing specimens.
Is there an association between cutaneous leishmaniasis and skin cancer? A systematic review
Authors: Carrillo-Larco Rodrigo M. , Acevedo-Rodriguez J. Gonzalo , Altez-Fernandez Carlos , Ortiz-Acha Karol , Ugarte-Gil Cesar
Published: July 2019

Background: Cutaneous leishmaniasis is a prevalent communicable disease in low- and middle-income countries, where non-communicable diseases like skin cancer are on the rise. However, the study of multi-morbidity or co-morbidity between communicable and non-communicable diseases is limited, and even null for some tropical or neglected diseases. Nevertheless, looking at these conditions together instead of as isolated entities in places where these illnesses exist, could show new prevention and treatment paths. We aimed to summarize and critically appraise the epidemiological evidence on the association between cutaneous leishmaniasis and skin cancer.

Methods: Following the PRISMA guidelines, we conducted a systematic review using five search engines (Embase, Medline, Global Health, Scopus and Web of Science). We sought observational studies in which the outcome was skin cancer whilst the exposure was cutaneous leishmaniasis; these conditions should have had laboratory or pathology confirmation.

Results: No epidemiological investigations have studied the association between cutaneous leishmaniasis and skin cancer. Most of the evidence about the association of interest is still based on case reports and other clinical observations rather than strong epidemiological observational studies.

Conclusions: Research is much needed to verify the repeatedly clinical observation that cutaneous leishmaniasis may be a risk factor for skin cancer. This evidence could inform and guide early diagnosis or prevention of skin cancer in survivors of cutaneous leishmaniasis or where cutaneous leishmaniasis is still highly prevalent.

Registration: PROSPERO ID CRD42018111230; registered on 16/10/18.
АНАЛИЗ ПРОГРАММНЫХ КОМПЛЕКСОВ И ОПЫТА ВНЕДРЕНИЯ BIM-ТЕХНОЛОГИЙ
Authors: Verbitsky Vladislav Andreevich
Published: July 2019

Основной задачей строительных организаций на данный момент является переход на BIM-технологии. Информационное моделирование или BIM технологии – это интегрированный процесс, основанный на скоординированной, надежной информации о проекте от проектирования до строительства и эксплуатации. В данной статье рассмотрены, сравнение существующих на рынке программных комплексов, а также государственное регулирование применения BIM-технологий в развитых странах.
ВОЗМОЖНОСТИ ТЕХНОЛОГИЙ МАШИННОГО ОБУЧЕНИЯ ДЛЯ УПРАВЛЕНИЯ БИЗНЕС-ПРОЦЕССАМИ УНИВЕРСИТЕТА
Authors: Tereshchenko Sergey Nikolaevich
Published: July 2019

Технологии машинного обучения развиваются стремительно. Имеется тенденция по упрощению доступности машинного обучения для различных сфер. Примером показан процесс приемной компании НГУЭУ.
ОБЩЕСТВЕННЫЙ ТРАНСПОРТ И ИННОВАЦИИ
Authors: Berman Nina Demidovna , Belov Alexander Mikhailovich
Published: July 2019

Эффективное функционирование транспортной системы региона создает необходимые условия для развития экономики и социальной сферы. Жители городов имеют различные потребности в мобильности и предпочтения при выборе транспортного средства для ежедневных поездок. Понимание различий в том, что нравится пассажирам общественного транспорта, и факторов, которые формируют эти предпочтения среди потребителей, имеет первостепенное значение для определения того, какие инновации являются наиболее эффективными и для каких слоев населения. Необходимо использовать такие формы обслуживания пассажиров, которые позволят изменить стиль жизни горожан и сделать общественный транспорт предпочтительным видом передвижения.
A Rare Case of Isolated Nontyphoidal Salmonella Lymphadenitis
Authors: Behrens Alice , Wang Hans , Kuriakose Kevin , Behrens Emily , Burns Matthew
Published: July 2019

Over 95% of cases of typhoidal and non-typhoidal Salmonella infection are foodborne. Focal Salmonellosis without bacteremia is rarely reported, especially the setting of non-enteric lymphadenitis. We present a rare case of Salmonella typhimurium inguinal lymphadenitis. We also reviewed major risk factors for focal Salmonellosis and appropriate treatments.
Large atrial septal defect misdiagnosed as arrhythmogenic right ventricular cardiomyopathy
Authors: Moore Lisa Marie , Cevik Cihan
Published: July 2019

We report on a case of a large ostium secundum atrial septal defect (ASD) that was initially diagnosed as arrhythmogenic right ventricular cardiomyopathy (ARVC). We discuss the initial work up, diagnosis, and treatment of this patient’s ASD and explore how the pathophysiology of ARVC may mimic congenital heart disease where there is a large left-to-right shunt.
Discordance between aPTT and anti-factor Xa levels and implications in patients receiving intravenous unfractionated heparin therapy
Authors: Opoku Akwasi , Iwuji Kenneth , Clough Brendon , Le Jacqueline , Moore McKenzie , Simmons Chelsi , Hyde Bridget
Published: July 2019

Heparin, one of the world’s oldest anticoagulation medications, accelerates the rate ofinhibition of previously activated clotting factors. It is most often used in the prophylaxis andtreatment of thromboembolic disorders and complications associated with atrial fibrillation.The two most common ways to monitor plasma heparin levels and anticoagulation therapyare the activated partial thromboplastin time (aPTT) and anti-factor Xa assay (anti-Xa). Thisarticle assesses the performance of aPTT and anti-Xa monitoring protocols and analyzes thediscordance between aPTT and anti-Xa levels and its clinical implications in patients receivingintravenous heparin therapy.
Effect of non-invasive mechanical ventilation with average volume assured pressure support (AVAPS) in patients with chronic obstructive pulmonary disease with acute exacerbation: A randomized pilot trial
Authors: Limsuwat Chok , Rawangnam Warunya , Ruangsomboon Onlak , Prapruetkit Nattakarn
Published: July 2019

Objectives: The primary goal of this study was to compare patient satisfaction betweenbi-level positive airway pressure-spontaneous/timed with average volume assured pressuresupport (BiPAP S/T with AVAPS) and BiPAP S/T alone in patients with acute exacerbationsof chronic obstructive pulmonary disease (AECOPD) using self-reported intensity of dyspneameasured with the modified Borg scale (MBS) and a numeric rating scale (NRS) and comfortlevel measured with a dyspnea and comfort scale.Methods: This pilot randomized clinical study was conducted in patients who presentedwith acute respiratory distress due to AECOPD to the Siriraj Hospital Emergency Department.Included patients were randomized in a 1:1 ratio to receive either BiPAP S/T with AVAPS(intervention) or BiPAP S/T (control). MBS, NRS, dyspnea and comfort scale, clinical information,and laboratory results were recorded and analyzed.Results: Twenty-two patients were enrolled (11 in each group). The average decrease inthe MBS, the NRS, and the dyspnea and comfort scale were higher in the group than the controlgroup (4.09 ± 1.81 vs. 2.91 ± 1.64; 4.09 ± 1.76 vs. 2.91 ± 1.92; 3.27 ± 2.45 vs. 3.00 ± 1.90,respectively). The average increase of patient satisfaction with overall comfort was higher inthe AVAPS group (1.64 ± 2.77 vs. 1.09 ± 3.02). However, none of these differences reachedstatistical significance.Conclusion: There was no statistically significant improvement in patient comfort usingAVAPS as an adjunct to standard BiPAP S/T therapy in this pilot study.
Acquired cystic fibrosis transmembrane conductance regulator protein (CFTR) dysfunction and cigarette smoking
Authors: Kopel Jonathan
Published: July 2019

Cystic fibrosis (CF) remains a prevalent genetically inherited disease in Caucasianpopulations. Investigation of the respiratory symptoms which occur in patients with CF helps usunderstand the pathophysiology of chronic lung disease. Environmental insults, such as cigarettesmoke, can reduce the cystic fibrosis transmembrane receptor (CFTR) function or expressionleading to an acquired CF phenotype and could contribute to the development and progressionof smoking-related lung disease. However, it is uncertain if the acquired CF phenotype can bediagnosed with the same methods, such as the sweat chloride test and the measurementof nasal potential difference, used for genetically-acquired CF. More studies are needed toinvestigate the prevalence of acquired CFTR dysfunction and the differences between acquiredand genetically-inherited CFTR dysfunction. Overall, acquired CFTR dysfunction challengesthe distinction between genetic and acquired disorders, suggesting that environmental agentsmay modulate the functions of genes and the increase risk for pulmonary disease.
Crossover design
Authors: Yang Shengpin , Berdine Gilbert
Published: July 2019

I am planning a clinical trial to compare two diets on reducing the risk of type II diabetes.Because there is a restriction on the total budget, I would prefer to enroll a small number ofparticipants. Meanwhile, it is important that there is sufficient statistical power to detect aclinically meaningful difference. Is there any study design that can be utilized?
The Possibility of a Scientific Approach to Analytic Theology
Authors: Torrance Andrew
Published: July 2019

A question that is often asked of analytic theologians is: what, if anything, distinguishes analytic theology from philosophy of religion? In this essay, I consider two approaches to what is called “analytic theology.” I argue that the first approach, which I associate with the common practice of analytic theology in the university, is very difficult to distinguish consistently from philosophy of religion. I also argue, however, that there is another approach that can be more clearly distinguished from philosophy of religion (generally understood). Following Aquinas, I associate this with a scientific approach to analytic theology: an approach that is distinguished by a specific commitment to understanding the mind-independent reality of God and all things in relation to God. The primary aim of this essay is to present an account of this latter approach and ask whether it might be possible to take such an approach in the contemporary university.
On Contradictory Christology: Preliminary Remarks, Notation and Terminology
Authors: Beall Jc
Published: July 2019

The following are some preliminary remarks that will set the stage for my individual replies to Timothy Pawl, Thomas McCall, A. J. Cotnoir, and Sara L. Uckelman’s responses to my paper ‘Christ – A Contradiction’. In that paper I advance and defend a contradictory Christology which solves the fundamental ‘problem’ of Christology by holding that Christ is a contradictory being: it is true that Christ is mutable and it is false that Christ is mutable; it is true that Christ is immutable and it is false that Christ is immutable; and so on for other fundamental-problem properties. Familiarity with ‘Christ – A Contradiction’ (and also with background discussion including, e.g., Richard Cross’s discussions of ‘the fundamental philosophical problem’) is assumed.
On Contradictory Christology: A Reply to Pawl’s ‘Explosive Theology’
Authors: Beall Jc
Published: July 2019

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On Contradictory Christology: A Reply to McCall’s ‘Doctrinal Orthodoxy and Philosophical Heresy’
Authors: Beall Jc
Published: July 2019

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Introduction to Vol. 7
Authors: ㅤ ㅤ
Published: July 2019

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Exhibition Review
Authors: Tseëlon Efrat
Published: July 2019

Helena Rubinstein: L’Aventure de la beauté, Museé d’art et d’histoire du judaïsme, Paris, 20 March–25 August 2019
Singing for Breathing Uganda: Group singing for people with chronic lung disease in Kampala
Authors: Downes Catherine , Philip Keir E. J. , Lewis Adam , Katagira Winceslaus , Kirenga Bruce
Published: July 2019

Group singing for people with chronic lung diseases has become increasingly popular in Europe, North America and Australia, with a growing body of research suggesting biopsychosocial benefits for participants. This article presents notes from the field and includes information about the programme sessions and programme evaluation, on Singing for Breathing (SFB) Uganda, a group singing programme for people with chronic lung diseases in Kampala, Uganda. Sessions were delivered by Ugandan singing leaders who were supported by a British Lung Foundation Singing for Lung Health trained leader. Sessions included physical, vocal and breathing warm-ups, rhythm and pitch games, repertoire and relaxation. Programme evaluation indicates that sessions were greatly enjoyed by participants and facilitators. Lessons learnt will inform the development of resources to support other groups in Uganda and other countries in sub-Saharan Africa.
A Cacophony of Signals: Woodpecker Sexbots, Squirrel NORAD, and Other Robotic Systems
Authors: Ingram Ian
Published: July 2019

This article discusses the author’s robotic artworks, which consider the human-made body's future as a willful entity and the nature of communication. The robots use computer vision or sound signal processing to search the world for the signals of target species and then attempt
to respond through similar gestural and audible signalling. The robots are trying to communicate with the animals and, in part, allow human communion with those animals in ways that human bodies and umwelts don't allow. That human narrative stamps itself heavily onto the projects is confirmed
by these becoming things like a hermaphroditic sexbot for Pileated Woodpeckers and a NORAD equivalent for Grey Squirrels.
Creature Comforts and the Ties that Bind
Authors: Olynyk Patricia
Published: July 2019

This essay is a meditation on the ways in which the scientific community and the arts community alike are feeling their way through the transdisciplinary subject of interspecies communication and how, in the absence of a single systematic program, both art and science can provide their
own platforms to challenge how humans habitually think about communicating with animals.Creature Comforts begins with an exploration oflaboratory animals and their relationshipswith their handlers, and ends with a probing look at the use and inclusion of lab animals in contemporary art.
Being Other Than We Are...
Authors: Barnett Heather
Published: July 2019

For a number of years, artist Heather Barnett has challenged groups of people to test their capacity for collective action against that of a single celled organism. The experiment, Being Slime Mould, invites a group of humans to operate as a superorganism, taskedwith some fundamental
ontological rules of a nonhuman intelligent life form through playful participation.Being (or becoming) slime mould is of course an impossibility; we can no more become slime mould than we can become badger or bat. The point of the exercise, therefore, is in the trying: the endeavour to
put aside human ego and individualism in order to shift perception towards other ways of sensing, knowing and being. Drawing on Barnett’s own artistic practice, and from the fields of ecology, philosophy and speculative design, this paper investigates the motivations and methods of humans
to engage philosophically and experientially with the sensory subjectivities of ontological others.
Umwelt Microbiana
Authors: Ong Joel , Lorusso Mick
Published: July 2019

This essay discusses a series of collaborative artworks by Joel Ong and Mick Lorusso envisioning a "Microbial Witness," a quiet but powerful protagonist founded in the interstitial spaces of science, art, and mythology. The artists systematically catalog its umwelt--the environmental
factors that affect it-- through the "Microbial Atlas." Ong and Lorusso propose that, through exposure to this artistic research process, their audience may also adopt an ecological/moral responsibility through a shared empathy with, and respect for, the microbial world. This work
continues their joint artistic querying of the role and position of the artist as “witness" in the spaces and artefacts of the scientific laboratory.
Animal Eyes: Gazing at the Animal in Video Games
Authors: Hobin Nicholas
Published: July 2019

Encounters with animals are common in video games, where they are often included to add realism to the gameworld. Encounters with animal subjectivity, however, are not. The anthropocentric nature of video games means that animals are often environmental objects, and sometimes resources,
but only occasionally characters, and rarely protagonists. As a consequence, there is no encounter with the animal presence, and often no shared gaze: The look of the animal is instead transformed into something wholly antagonistic (such as in Horizon Zero Dawn), wholly submissive (as in Far
Cry Primal) or absent entirely (Red Dead Redemption). Even when video game animals are designed with the intention of “appreciating” the animals, the privileging of their panoptic human spectators just as often results in their objectification.
[WHAT’S HAPPENING?] I’M FEELING EMOTIONAL
Authors: Battle Christina
Published: July 2019

[What’s Happening?] I’m feeling emotionallooks to how animated GIFS, used as emotional aides in online conversation, might be changing the ways that we relate. While the reliance on GIFs as stand-ins for emotional expressions may be a way to build the social back into online
communication and a reaffirmation of the role of emotion in society as an important and even critical requirement; the essay considers how the over representation of fictional characters, animals, and cultural stereotypes selected by algorithms may be shifting culture in ways we haven’t
yet realized.
‘Yo soy Groot’: Afro-Caribbean religions and transnational identity in the comic metropolis
Authors: Humphrey Paul
Published: July 2019

This article examines the ways in which Afro-Caribbean superheroes engage with questions of identity, movement and belonging as they embody diverse and culturally hybrid populations within the North American imaginary. First engaging with scholarship regarding the writing of race and marginalized cultures in US comics to situate the Santerians, Brother Voodoo/Doctor Voodoo and Groot within the larger comic book oeuvre, it turns to explore how these Marvel characters incorporate the myths and spiritual powers of Cuban/Puerto Rican Santería and Haitian Vodou into the metropolitan narratives in which they are depicted. As corporeal representations of these religions within the cultural landscapes of New York City and New Orleans, these transnational superheroes have each been physically and/or culturally displaced to the margins but see their hybrid identities valorized to greater or lesser degrees within the cultural framework of the metropolis. However, in spite of these characters having challenged stereotypical and hegemonic representations of racial and ethnic alterity, they are still subject to a clear hierarchy between the metropolis and the periphery. This is most clearly communicated through the restrictions and processes of othering that the Santerians and Brother Voodoo/Doctor Voodoo suffer, in comparison to the success and global mobility enjoyed by those more established characters alongside which they appear. As such, although the writing of these characters is both culturally sensitive and has permitted the development of new knowledges within the comic metropolis, at the same time these superheroes remain subordinate to their white, metropolitan counterparts and see themselves marginalized within very narrative that has sought to celebrate their transnational and hybrid identities.
An interview with Julia Kaye
Authors: Murel Jacob
Published: July 2019

Julia Kaye is a transgender cartoonist who recently published her first book Super Late Bloomer: My Early Days in Transition (Kaye 2018) with comics publisher Andrews McMeel. The book is a bound collection of select strips from her acclaimed web comic Up and Out. Though her web comic began as a run-of-the-mill gag strip, Up and Out transformed alongside Kaye herself into an autobiographical comic documenting her personal life as a transgender woman. Super Late Bloomer is comprised from a selection of these daily, autobiographical strips that document Kaye’s first months in hormone transition. The book was published in May 2019 and was acclaimed by reviewers. It presents a new format for the currently in vogue graphic memoir movement, a comics diary, an autobiographical collection comprised of quotidian, piecemeal installments from the artist’s daily experience. Kaye currently lives in Los Angeles where she works for Disney on the television show Big City Greens (2018–9) and continues to update her web comic Up and Out.
An interview with Arthur Ranson
Authors: Klaehn Jeffery
Published: July 2019

Arthur Ranson (b. 1939) is a British artist widely known for his work on Look-in (Danger Mouse, Sapphire & Steel) and 2000AD (Anderson: Psi-Division, Shamballa, Mazeworld, Button Man). This interview, undertaken throughout July–October 2018, explores his career as an illustrator and artist and explores a range of topics, including key points in his career; his approach to composition, colour and storytelling; comics and realism; whether comics are, as Jack Kirby once declared, journalism; artists he admires, including Mike Mignola, Neal Adams, Alex Ross, Jack Kirby and Allison Bechdel; the Bechdel test and representations of female characters in comics; reflections on Cassandra Anderson; the Judge Dredd films; John Wagner; Mazeworld; his collaborations with writer Alan Grant; and the single panel from his incredibly body of work in comics and illustration that he’s most proud of.
Invoking the past in graphic biographies: The life, death and ghostly return of Alexandre Bóveda
Authors: Miranda-Barreiro David
Published: July 2019

Ruth Hoberman suggests that ‘biography is the terrain on which each generation works out crucial questions about its relation to the past’, and perhaps the most crucial question of Spain’s recent history has been that of how to deal with the memory of the Spanish Civil War (1936–39) and General Franco’s dictatorship (1939–75). Drawing on existing scholarship that has described the repressed memories of Spain’s past as ghostly, this article will examine the conjuring power of memory to bring the ghosts of the traumatic past to the present in graphic biographies, taking as case study the Galician comic Bóveda (2012) by María Xesús Arias (writer) and Carlos Sardiña (artist), about the life of the politician Alexandre Bóveda (1903–36), executed by Francoist forces at the outbreak of the Spanish Civil War. The analysis will also address the specificities of the comics medium to ‘bring back’ the bodies of the victims of the war compared to filmic representations of historical figures in biopics and documentaries. Because of the emblematic role that he has played in the imaginary of Galician nationalism, Alexandre Bóveda has become a national symbol of the traumatic suffering inflicted on Galicia by Francoism. Pramod K. Nayar suggests that graphic biographies provide ‘a new mode’ to address social systems of oppression. Following this assertion, the analysis of Bóveda will not only reflect on the representation of the life of an individual but also on how by invoking his memory, the whole national project embodied by this politician is also reclaimed. In this light, the graphic biography challenges the fallacy of Galician peaceful submission to Francoism while also highlighting the strength of the project of Galician autonomy before the war.