bluuebunny/crossref_metadata_2025 huggingface dataset:
3D Facial Analysis in Class II Subdivision Malocclusion
Authors: Candida Ettore , Grippaudo Francesca R. , Romeo Cristiana , Tauro Rosita , Blasi Anna , Grippaudo Cristina
Published: April 2022

Background:

Class II subdivision is an asymmetric condition presenting a Class I dental occlusion on one side and a Class II on the contralateral one. It presents a midline deviation that may be caused by a monolateral distalization of the mandible (type 1) or a mesialization of one side of the maxilla (type 2). The evaluation of asymmetry based on 2D radiographic records has been demonstrated to be less accurate than the one made using 3D radiographs.

Objective:

The aim of this work is to evaluate the facial asymmetry in a group of patients with Class II subdivision, compared to patients in Class I without evident asymmetry, by using 3D photographs of the face.

Methods:

32 young adults with Class II subdivision were compared to a group of 32 subjects with bilateral Class I molar relationship. 3D photograph of their face was acquired using a stereophotogrammetric camera (3dMDtrio System-3dMD Atlanta, GA, USA). 3D photographs were imported into the Geomagic Software to create mirror 3D photography. Independent T-tests were made to compare facial asymmetries measured on Class II subdivision group with the Class I group.

Results:

The results show that there is a statistically significant difference in landmarks location between the control group and the experimental group regarding the values measured at the level of the lips and the perioral area. The asymmetry was more marked in patients with mandibular midline deviation. This is in line with previous observations with radiographic investigations.

Conclusion:

For a correct assessment of the asymmetry, a study of 3D photographs cannot replace an evaluation by cone beam, but it can be an important aid to estimate possible asymmetries in the perioral area and in the lip area.
Gingival Squamous Cell Carcinoma Masquerading as Localized Periodontal Disease in the Maxilla: A Case Report
Authors: Jalali Elnaz , Mago Jyoti , Tadinada Aditya
Published: April 2022

Objectives:

Squamous cell carcinoma is a malignant neoplasm of epithelium. In the U.S., carcinoma of the gingiva constitutes 4% to 16% of all oral carcinomas. This case report highlights such a case in maxillary gingiva and emphasizes the vital role of dental professionals, especially periodontists and endodontists, in being cognizant that an inflammatory lesion can mimic a serious condition like squamous cell carcinoma.

Case Presentation:

A patient who visited the screening clinic for an ulcerated lesion in the gingiva was otherwise healthy with no associated history of tobacco or any traumatic/persistent traumatic events.

The patient was treated for pseudoepitheliomatous hyperplasia based on the current condition and negative history of malignancy. On three months of follow-up, computed tomography radiographic evaluation and a biopsy were done, which were positive for the malignancy. Follow-up after six months includes PET, Head MRI, and chest X-ray examinations to rule out any metastatic entity.

Results:

A six-month follow-up radiographic examination revealed metastasis of the entity. Additional findings include pleural effusion and underlying infections.

Conclusion:

Early diagnosis is the key to the treatment plan. It further highlights the role of advanced imaging as a vital tool in determining the extent of the disease. Therefore, any persistent lesion exhibiting features that are not responding to conventional gingival and periodontal treatment options for more than two weeks should be referred for further evaluation to rule out cancer.
Analysis of Expression of Myofibroblasts in Oral Submucous Fibrosis: An Immunohistochemistry Study
Authors: Puri Nidhi , Ahuja Upasana S. , Gupta Ritu , Gandhi Piyush , Punia Ramandeep S. , Choudhary Akshi
Published: April 2022

Background:

Oral submucous fibrosis (OSMF) is a chronic disease that produces tissue fibrosis and is considered to be a potentially malignant disorder. The exact pathogenesis and malignant conversion mechanism of this disorder are still unknown. Myofibroblasts have been implicated as one of the possible pathological mechanisms responsible for the pathophysiology of OSMF. The present study was conducted to evaluate the expression of myofibroblasts (MF) in normal mucosa and different grades of OSMF.

Materials & Methods:

The sample consisted of a total of 80 specimens. The study group included specimens from clinically and histopathologically confirmed OSMF patients. The specimens were divided into four groups. Group 1 consisted of 19 specimens of grade III OSMF. Group II had 20 specimens of grade II OSMF, Group 3 with 21 specimens of grade I OSMF, and Group 4 constituted a control group of 20 normal epithelium specimens. Two sections each from all the four groups were obtained. While one section was stained with H and E, the other section was stained immunohistochemically using α-smooth muscle antibody. For analysis, the expression of myofibroblasts was categorized as strong, moderate, weak, or absent. All the results were recorded and subjected to statistical analysis.

Results:

In OSMF patients, irrespective of the grade, the expression of myofibroblast was strong in 28.33 percent of the patients, while it was moderate and weak in 30.00 percent and 40.00 percent of the patients, respectively. Expression of myofibroblast was noted to be significantly increased in grade III OSMF patients as compared to controls as well as grade I OSMF patients (p-value <0.05).

Conclusion:

Myofibroblasts expression is significantly raised in OSMF patients. The expression can also be correlated within different grades of OSMF where advanced stages show comparatively high expression of these smooth muscles like fibroblasts. Hence, we suggest that myofibroblasts could be assessed as markers for analyzing the progression of OSMF.
Evaluation of Neutrophilic Receptors; CXCL8 and CXCR2 in Patients with Chronic Periodontitis Compared to Healthy Subjects by Real Time PCR Method
Authors: Shiezadeh Farid , Azami Negar , Arab Hamid Reza , Rezaee Seyed Abdol Rahim , Moeintaghavi Amir , Banihashemrad Ahmad
Published: April 2022

Objective:

This study aimed to evaluate the levels of CXCL8 and its receptor (CXCR2) in gingival tissue neutrophils from patients with chronic periodontitis compared to periodontal healthy subjects using Real Time PCR method.

Methods:

The test group consisted of 21 patients with chronic periodontitis and the control group consisted of 18 healthy individuals. In both groups, gingival tissue samples were obtained during periodontal surgery.CXCL8 and CXCR2 RNA in tissue samples were examined by PCR method, and then the levels of genes expression were measured. Mann-Whitney U nonparametric test was used for statistical analysis.

Results:

CXCL8 gene expression in the gingival tissue of the test group with chronic periodontitis was significantly higher than the control group (p=0.028). CXCR2 gene expression in the gingival tissue of the test group with chronic periodontitis was significantly lower than the control group (p=0.043). In both test and control groups, there was a negative correlation between CXCL8 and CXCR2 gene expression. This correlation was statistically significant in the test group (p=0.001), but there was no significant correlation in the control group (p=0.431).

Conclusion:

The results of this present study suggested that the level of gene expression for CXCL8 was greater in patients with chronic periodontitis and CXCR2 was greater in healthy individuals. Although in people with chronic periodontitis, CXCR2 decreases slightly as CXCL8 levels increase.
Circulating MicroRNAs as a New Class of Biomarkers of Physiological
Reactions of the Organism to the Intake of Dietary Supplements and
Drugs
Authors: Postnikov Pavel V. , Efimova Yulia A. , Pronina Irina V.
Published: April 2022

Background:

The analysis of individual microRNAs (miRNAs) as a diagnostic and prognostic tool for the effective treatment of various diseases has aroused particular interest in the scientific community. The determination of circulating miRNAs makes it possible to assess biologi-cal changes associated with nutritional processes, the intake of dietary supplements and drugs, etc. The profile of circulating miRNAs reflects the individual adaptation of the organism to the effect of specific environmental conditions.

Objective:

The objective of this study is to systematize the data and show the importance of circu-lating miRNAs as new potential biomarkers of the organism's response to the intake of various die-tary supplements, drugs, and consider the possibility of their use in doping control.

Method:

A systematic analysis of scientific publications (ncbi.nlm.nih.gov) on the miRNA expres-sion profile in response to the intake of dietary supplements and drugs most often used by athletes, and supposed their role as potential markers in modern doping control was carried out.

Results:

The profile of circulating miRNAs is highly dependent on the intake of a particular drug, and, therefore, may be used as a marker of the effects of biologically active supplements and drugs including the substances from the Prohibited List of the World Anti-Doping Agency (WADA).

Conclusion:

Monitoring of circulating miRNAs can serve as a high-precision marker for detecting doping abuse in elite sports. However, it is necessary to conduct additional studies on the effect of complex drugs on the profile of circulating miRNAs and individual circulating miRNAs on a par-ticular biological process.
Cinética de secado por convección del epicarpio de calabaza de Cucurbita Maxima y sus usos en el desarrollo de pan sin gluten
Authors: López Mejía Natali , Morales Posada Nelly Bibiana , Lobatón García Hugo Fabian
Published: April 2022

Con este estudio se obtuvieron modelos matemáticos semi-empíricos que representan la cinética de secado convectivo del epicarpio de zapallo a diferentes temperaturas (55, 65 y 75 ° C / 10% HR / velocidad de secado 1ms-1). Se seleccionó la mejor condición de secado con la que se obtuvo la harina, la cual se caracterizó y utilizó para la elaboración de la torta libre gluten. Posteriormente, se evaluó el efecto de incorporar harina de epicarpio de calabaza en 4 niveles (control 0, 15, 20 y 25g / 100 g de harina) sobre la aceptación sensorial de la torta. Como resultados se obtuvo que el modelo de dos términos describe mejor la curva obtenida a 55 ° C, y el modelo logarítmico describe mejor las curvas obtenidas a 65 ° C y 75 ° C. Se seleccionó la temperatura de 65 ° C como la mejor condición de secado. Finalmente, la mayor aceptación e intención de compra se obtuvo en el pan formulado con 15 g  / 100 g de harina de epicarpio de calabaza.
English Linguistic Imperialism from Below
Authors: Mathew Leya
Published: April 2022

The book shows how English has been newly constituted as a dominant language in post-market reform India. Political economic transitions experienced as radical social mobility fuelled intense non-elite desire for English schooling. Rather than English schooling leading to social mobility, new experiences of mobility necessitated English schooling.
Application of a microcontroller in automatic electrical domestic changeover system
Authors:   Department of Electrical Engineering, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia, Asghar Nura
Published: April 2022

The design, development, and simulation of an automatic Electrical Mains Changeover System (EMCS) using a PIC microcontroller (μC) has been presented in this study. The system consists of an 18-pin DIP package enhanced flash microcontroller PIC16F84A with a 4 MHz crystal used as the main processor, two switching transistors, two relays, and a Low Voltage Power Supply (LVPS). The electrical mains control signal output at RB0 and RB2 of PortB actuate two switching transistors which drive two relays to operate the loads depending on the availability of mains or backup power source. An assembly language program based on MPLAB IDE has been developed to control the operation of the system. The design and verification of the PIC μC based EMCS in the Proteus 8 simulation platform have been completed successfully.
Caracterización del sistema productivo de papa en el departamento de Nariño 2015-2020: Conocimiento para la toma de decisiones
Authors: Martínez Pachón Eliana , Insuasty Cordoba Sandra del Carmen , Benavides Cardona Carlos Andrés , Gómez Gil Luis Fernando , Uribe Mejía Pedro , Marcillo Paguay Carlos Alberto , Calvache Muñoz David Andrés , Mejía España Diego Fernando , Arana Chico Henry Camilo , Ramos Zambrano Housseman Steven , López Peñafiel Hyrcania Vanessa , Latorre Vásquez Laura , Luna Mancilla Lizeth Tatiana , Rincón Manrique Luis Felipe , Valencia Flórez Luis Fernando , Pérez Cabrera Mildred Katherine , Yandar Erazo Sabely Nataly , Trejo Escobar Diego
Published: April 2022

El presente libro reúne los resultados de investigación sobre la caracterización de las tecnologías locales de producción de papa, los aspectos socioeconómicos de la cadena y la sistematización del proceso de fortalecimiento de capacidades locales en la producción de semilla de calidad orientados a mejorar y optimizar el desempeño del sector en el departamento de Nariño. El manuscrito aporta a los tomadores de decisiones, académicos y público en general elementos para mejorar la comprensión del estado actual del sector, sus retos y perspectivas de intervención, no solo desde la CTeI agropecuaria, sino también desde la sostenibilidad social y ambiental. Los lectores podrán encontrar en el texto un soporte actualizado y con información pertinente para la toma de decisiones que, de alguna manera, propenda por mejorar el nivel de vida de los cultivadores de papa de Nariño y, por extensión, del país.
Conozca a sus aliados para el manejo del barrenador Diatraea spp. en caña de azúcar para panela
Authors: Barreto Triana Nancy , Osorio Mejía Pablo Andrés , Insuasty Burbano Orlando Ildefonso , Sarmiento Naizaque Zaida Xiomara , Sandoval Cáceres Yuly Paola , Barona Rodríguez Ayda Fernanda , Jiménez Vargas Javier , Gómez Benavides Jesús
Published: April 2022

Esta cartilla da a conocer las especies de barrenadores de la caña de azúcar para la industria panelera, los porcentajes de intensidad de infestación (daño) y los parasitoides asociados, encontrados en siete departamentos de Colombia. También, ofrece recomendaciones para su manejo soportadas en los resultados obtenidos en la Hoya del río Suárez, validadas directamente en fincas de productores
Toward Using Twitter for PrEP-Related Interventions: An Automated Natural Language Processing Pipeline for Identifying Gay or Bisexual Men in the United States
Authors: Klein Ari Z , Meanley Steven , O'Connor Karen , Bauermeister José A , Gonzalez-Hernandez Graciela
Published: April 2022

Background

Pre-exposure prophylaxis (PrEP) is highly effective at preventing the acquisition of HIV. There is a substantial gap, however, between the number of people in the United States who have indications for PrEP and the number of them who are prescribed PrEP. Although Twitter content has been analyzed as a source of PrEP-related data (eg, barriers), methods have not been developed to enable the use of Twitter as a platform for implementing PrEP-related interventions.

Objective

Men who have sex with men (MSM) are the population most affected by HIV in the United States. Therefore, the objectives of this study were to (1) develop an automated natural language processing (NLP) pipeline for identifying men in the United States who have reported on Twitter that they are gay, bisexual, or MSM and (2) assess the extent to which they demographically represent MSM in the United States with new HIV diagnoses.

Methods

Between September 2020 and January 2021, we used the Twitter Streaming Application Programming Interface (API) to collect more than 3 million tweets containing keywords that men may include in posts reporting that they are gay, bisexual, or MSM. We deployed handwritten, high-precision regular expressions—designed to filter out noise and identify actual self-reports—on the tweets and their user profile metadata. We identified 10,043 unique users geolocated in the United States and drew upon a validated NLP tool to automatically identify their ages.

Results

By manually distinguishing true- and false-positive self-reports in the tweets or profiles of 1000 (10%) of the 10,043 users identified by our automated pipeline, we established that our pipeline has a precision of 0.85. Among the 8756 users for which a US state–level geolocation was detected, 5096 (58.2%) were in the 10 states with the highest numbers of new HIV diagnoses. Among the 6240 users for which a county-level geolocation was detected, 4252 (68.1%) were in counties or states considered priority jurisdictions by the Ending the HIV Epidemic initiative. Furthermore, the age distribution of the users reflected that of MSM in the United States with new HIV diagnoses.

Conclusions

Our automated NLP pipeline can be used to identify MSM in the United States who may be at risk of acquiring HIV, laying the groundwork for using Twitter on a large scale to directly target PrEP-related interventions at this population.
Augmented Reality-Based Surgery on the Human Cadaver Using a New Generation of Optical Head-Mounted Displays: Development and Feasibility Study
Authors: Puladi Behrus , Ooms Mark , Bellgardt Martin , Cesov Mark , Lipprandt Myriam , Raith Stefan , Peters Florian , Möhlhenrich Stephan Christian , Prescher Andreas , Hölzle Frank , Kuhlen Torsten Wolfgang , Modabber Ali
Published: April 2022

Background

Although nearly one-third of the world’s disease burden requires surgical care, only a small proportion of digital health applications are directly used in the surgical field. In the coming decades, the application of augmented reality (AR) with a new generation of optical-see-through head-mounted displays (OST-HMDs) like the HoloLens (Microsoft Corp) has the potential to bring digital health into the surgical field. However, for the application to be performed on a living person, proof of performance must first be provided due to regulatory requirements. In this regard, cadaver studies could provide initial evidence.

Objective

The goal of the research was to develop an open-source system for AR-based surgery on human cadavers using freely available technologies.

Methods

We tested our system using an easy-to-understand scenario in which fractured zygomatic arches of the face had to be repositioned with visual and auditory feedback to the investigators using a HoloLens. Results were verified with postoperative imaging and assessed in a blinded fashion by 2 investigators. The developed system and scenario were qualitatively evaluated by consensus interview and individual questionnaires.

Results

The development and implementation of our system was feasible and could be realized in the course of a cadaver study. The AR system was found helpful by the investigators for spatial perception in addition to the combination of visual as well as auditory feedback. The surgical end point could be determined metrically as well as by assessment.

Conclusions

The development and application of an AR-based surgical system using freely available technologies to perform OST-HMD–guided surgical procedures in cadavers is feasible. Cadaver studies are suitable for OST-HMD–guided interventions to measure a surgical end point and provide an initial data foundation for future clinical trials. The availability of free systems for researchers could be helpful for a possible translation process from digital health to AR-based surgery using OST-HMDs in the operating theater via cadaver studies.
Using Natural Language Processing and Machine Learning to Preoperatively Predict Lymph Node Metastasis for Non–Small Cell Lung Cancer With Electronic Medical Records: Development and Validation Study (Preprint)
Authors: Hu Danqing , Li Shaolei , Zhang Huanyao , Wu Nan , Lu Xudong
Published: April 2022

BACKGROUND

Lymph node metastasis (LNM) is critical for treatment decision making of patients with resectable non–small cell lung cancer, but it is difficult to precisely diagnose preoperatively. Electronic medical records (EMRs) contain a large volume of valuable information about LNM, but some key information is recorded in free text, which hinders its secondary use.

OBJECTIVE

This study aims to develop LNM prediction models based on EMRs using natural language processing (NLP) and machine learning algorithms.

METHODS

We developed a multiturn question answering NLP model to extract features about the primary tumor and lymph nodes from computed tomography (CT) reports. We then combined these features with other structured clinical characteristics to develop LNM prediction models using machine learning algorithms. We conducted extensive experiments to explore the effectiveness of the predictive models and compared them with size criteria based on CT image findings (the maximum short axis diameter of lymph node >10 mm was regarded as a metastatic node) and clinician’s evaluation. Since the NLP model may extract features with mistakes, we also calculated the concordance correlation between the predicted probabilities of models using NLP-extracted features and gold standard features to explore the influence of NLP-driven automatic extraction.

RESULTS

Experimental results show that the random forest models achieved the best performances with 0.792 area under the receiver operating characteristic curve (AUC) value and 0.456 average precision (AP) value for pN2 LNM prediction and 0.768 AUC value and 0.524 AP value for pN1&N2 LNM prediction. And all machine learning models outperformed the size criteria and clinician’s evaluation. The concordance correlation between the random forest models using NLP-extracted features and gold standard features is 0.950 and improved to 0.984 when the top 5 important NLP-extracted features were replaced with gold standard features.

CONCLUSIONS

The LNM models developed can achieve competitive performance using only limited EMR data such as CT reports and tumor markers in comparison with the clinician’s evaluation. The multiturn question answering NLP model can extract features effectively to support the development of LNM prediction models, which may facilitate the clinical application of predictive models.
Risk of hospitalization and mortality after breakthrough SARS-CoV-2 infection by vaccine type utilizing medical claims data (Preprint)
Authors: Kshirsagar Meghana , Mukherjee Sumit , Md Nasir , Becker Nicholas , Dodhia Rahul , Ferres Juan Lavista , Richardson Barbra
Published: April 2022

UNSTRUCTURED

Understanding the severity of SARS-CoV-2 breakthrough infections by vaccine type is important for making policy decisions regarding booster vaccinations. We compare the risks of hospitalization (n=1140) and mortality (n=159) in a SARS-CoV-2 positive cohort of 19,815 patients who were all fully vaccinated with either the Pfizer, Moderna or Janssen vaccines. Cox regression analysis comparing the three vaccines’ effectiveness in severity of the breakthrough infection showed lower hazard ratios for those receiving the Moderna vaccine and Pfizer vaccine (the lowest hazard rates being for Moderna), as compared to those who received the Janssen vaccine. Further, individuals who had a SARS-CoV-2 infection prior to vaccination had some increased protection over and above the protection already provided by the vaccines, from the risk of hospitalization (P<0.001) and mortality (P<0.05), independent of age, sex, comorbidities, and vaccine type.
Profil Penggunaan Kosmetika di kalangan Remaja Putri SMK Indonesia Yogyakarta
Authors: Lestari Ratih Dwi , Widayati Aris
Published: April 2022

Remaja memiliki kecenderungan senang bereksplorasi dengan mencoba berbagai jenis produk kosmetika. Namun demikian, keamanan harus menjadi pertimbangan dalam pemilihan dan penggunaan produk kosmetika. Penelitian ini bertujuan untuk mendeskripsikan profil penggunaan kosmetika di kalangan remaja putri. Penelitian ini bersifat deskriptif, yang merupakan studi pendahuluan (preliminary research) dari studi yang lebih besar tentang perilaku penggunaan kosmetika di kalangan remaja putri. Responden penelitian adalah siswa putri SMK INDONESIA Yogyakarta. Data dikumpulkan dengan panduan wawancara terstruktur dalam bentuk google form kepada 294 responden. Data dianalisis secara deskriptif. Hasil penelitian ini menunjukkan terdapat 19 jenis sediaan kosmetika untuk wajah. Alasan menggunakan kosmetika diantaranya untuk merawat kulit wajah (87%), menambah kepercayaan diri (8%), mengikuti trend (2%), menghilangkan jerawat (1%), agar kulit tidak kusam (1%), dan penghargaan pada diri sendiri (1%). Sumber informasi produk kosmetika diperoleh melalui media sosial (32%),  teman (23%), internet (20%), saudara 17%, dan iklan TV (8%). Tempat membeli produk kosmetika diantaranya toko/swalayan (59%), online shop (27%), dan klinik kecantikan (14%). Penelitian lebih lanjut diperlukan untuk menggali faktor yang mempengaruhi perilaku penggunaan kosmetika di kalangan remaja putri dan aspek keamanan dari kosmetika yang banyak digunakan.
Analisis Farmakoekonomi (Cost Effectiveness Analysis) Penggunaan Terapi Infus Imunoglobulin Intravena (IVIG) Pada Kasus Coronary Virus Disease (Covid-19)
Authors: Issaura Issaura , Azizah Novianti Fatli , Faizah Renny Nurul , Jami'atusholihah Ika Putri , Rahmania Shafinaz Nabila
Published: April 2022

Imunoglobulin Intravena (IV IG) merupakan produk derivatif plasma pendonor yang dapat memberikan proteksi imun secara pasif terhadap berbagai macam patogen. Pada infeksi Covid-19 yang berat, pemberian terapi infus IV IG dapat mengurangi respon inflamasi, antibodi autoreaktif yang mengikat sitokine dan domain variabel antibodi lain (antibodi anti-idiotipik). Selain itu, kehadiran dimer IgG pada IV IG dapat memblokir pengaktifan FcγR pada sel efektor imun. Tujuan untuk menganalisis Average Cost Effectiveness Ratio (ACER) dan Length of Stay (LOS) penggunaan terapi IV IG sebagai penilaian terhadap urgensitas pemberian terapi IV IG pada pasien COVID-19. Penelitian ditinjau dari perspektif rumah sakit sebagai penyedia layanan kesehatan, menggunakan Total Medical Cost dengan efektifitas LOS pasien. Disajikan dengan analisis deskriptif dan analisa farmakoekonomi efektifitas biaya yang dikerjakan secara retrospektif, pada periode waktu 3 bulan (Juni- Agustus 2020) di Instalasi Rawat Inap Intensive Care Unit (ICU) Isolasi Mawar Merah Putih RSUD Kabupaten Sidoarjo. Didapatkan jumlah sampel yang masuk kriteria inklusi 38 pasien. Kelompok pasien tanpa pemberian IV IG (25 pasien) lebih cost effective dibanding kelompok dengan pemberian IV IG, yaitu lebih menghemat Rp. 2.510.741 dengan LOS ICU 11 hari dibanding IV IG merk Gamaras® (4 pasien), dan lebih menghemat Rp 3.702.561 dengan LOS ICU 6 hari dibanding IV IG merk Intratect® (9 pasein). Dengan uji statistik tanpa pemberian IVIG dengan IVIG merk Gamaras® dan Intratect® menunjukkan LOS tidak bermakna (sig>0,05) dan ACER yang berbeda bermakna (sig
Gambaran Pelaporan Inspeksi Berkala Setelah Diberlakukan Sistem Pelaporan Online
Authors: Yunita Wijayanti Vika Marlyn
Published: April 2022

Pendahuluan: Pelaporan inspeksi berkala sebelumnya dilakukan dengan menggunakan form checklist kemudian data inspeksi dimasukkan ke dalam tabel Excel secara manual. Hal tersebut dinilai tidak efektif karena banyak menggunakan kertas, lembar inspeksi kurang komunikatif, waktu pelaksanaan inspeksi tidak terpantau dan pengelolaan data pelaporan membutuhkan waktu relatif lama. Instalasi Farmasi RSUP Dr Sardjito berinovasi dengan menerapkan inspeksi berkala berbasis online. Penelitian ini bertujuan melihat peningkatan jumlah pelaksanaan inspeksi, ketepatan waktu pelaporan inspeksi, dan kesesuaian pengisian inspeksi berkala setelah pelaksanaan pelaporan inspeksi online. Metode: Penelitian ini menggunakan metode deskriptif observasional. Sampel yang digunakan adalah 109 ruang yang digunakan sebagai lokasi penyimpanan obat di RSUP Dr Sardjito. Analisis data dilakukan dengan menghitung persentase pelaksanaan inspeksi, ketepatan waktu inspeksi, dan kesesuaian pengisian inspeksi dari google form dan aplikasi. Hasil. Jumlah pelaksanaan inspeksi naik sebesar 5,51% saat menggunakan aplikasi dibandingkan dengan manual. Terjadi peningkatan ketepatan waktu pelaporan inspeksi sebesar 7,7% setelah menggunakan aplikasi online dibandingkan saat menggunakan google form. Terjadi peningkatan kesesuaian pengisian data inspeksi setelah menggunakan google form sebesar 15% sedangkan dengan menggunakan aplikasi meningkat sebesar 34,38%. Kesimpulan. Terjadi peningkatan jumlah dalam pelaksanaan inspeksi, ketepatan waktu pelaporan inspeksi dan kesesuaian pengisian inspeksi berkala setelah pelaksanaan inspeksi berkala online.
Potensi Interaksi Obat Pada Pasien Covid-19 Terkonfirmasi Dengan Komorbid di Bangsal Ogan RSUP Dr. Mohammad Hoesin Palembang Periode April-Juni 2021
Authors: Yuniar Yuniar , Ramadhiani Aninditha Rachmah , Asyifa Dini , Ade Putri Winda Kirana , Apriliana Winta Sari
Published: April 2022

Latar Belakang: Corona virus Disease 2019 (COVID-19) merupakan penyakit menular yang disebabkan oleh sindrom pernapasan akut coronavirus-2 (severe acute respiratory syndrome coronavirus 2 atau SARS-CoV-2). Tantangan pengobatan pasien Covid -19 salah satunya adalah pada pasien dengan komorbid. Pemilihan terapi Covid-19 perlu mempertimbangkan interaksi obat Covid-19 dengan pengobatan penyakit komorbid. Mayoritas penderita penyakit penyerta mengalami polifarmasi, sehingga akan meningkatkan potensi terjadinya interaksi obat. Tujuan: tujuan penelitian ini yaitu untuk untuk mengetahui interaksi obat dan mencegah terjadinya interaksi obat yang potensial pada pasien Covid-19 dengan komorbid di bangsal Ogan RSUP Dr.Mohammad Hoesin Palembang. Metode: penelitian ini merupakan penelitian observasional yang dilakukan secara prospektif pada pasien Covid-19 terkonfirmasi dengan Komorbid yang dirawat di bangsal Ogan RSUP Dr. Mohammad Hoesin Palembang periode April-Juni 2021. Analisis interaksi obat menggunakan aplikasi Lexicomp. Tingkat keparahan interaksi ditentukan berdasarkan tingkat resiko, tingka tkeparahan, dan tingkat reliabilitas. Hasil: sampel dari penelitian ini berjumlah 23 pasien dengan jumlah potensi interaksi obat 94 interaksi. Persentase penyakit penyerta tertinggi ialah Hipertensi sebesar 48%. Serta persentase penggunaan obat>5 obat sebanyak 100%. Berdasarkan mekanisme, interaksi farmakodinamika 69% kejadian dan interaksi farmakokinetika 31% kejadian interaksi. Berdasarkan tingkat resiko interaksi persentase tertinggi pada kategori C sebesar 77% sehingga diperlukan pemantauan terapi. Berdasarkan tingkat keparahan, interaksi obat moderate tertinggi dengan persentase 74% kejadian, interaksi minor 21% kejadian, dan interaksi mayor 5% kejadian. Berdasarkan tingkat reliabilitas, persentase tertinggi pada kategori fair dengan 72 interaksi, good 18 interaksi, dan Excellent 5 interaksi.
Pengaruh Kecepatan Pencampuran Terhadap Sifat Fisik Lotion Nano-Ekstrak Etanol Kulit Buah Pisang (Musa balbisiana Colla) dan Daun Teh Hijau (Camellia sinensis L. Kuntze)
Authors: Ermawati Dian Eka , Putri Alfia Andhika
Published: April 2022

Kulit pisang kepok (M. balbisiana Colla) dan daun teh hijau (C. sinensis L. Kuntze) memiliki aktivitas antioksidan. Teh hijau mengandung katekin 20-30% meliputi epikatekin, epikatekin-3-galat, epigalokatekin, dan epigalokatekin-3-galat dengan nilai IC50 21,44 µg/mL. Kulit pisang kepok mengandung galokatekin, epikatekin, dan katekin. Aktivitas antioksidan pisang kepok yaitu 94,25% dengan nilai IC50 64,03±2,78 ppm yang tergolong sangat aktif. Pemakaian ekstrak sebagai zat aktif kosmetik memiliki pharmaceutical elegance rendah, sehingga ekstrak diformulasikan dalam SNEDDS (Self Nano-Emulsifying Drugs Delivery System). Maserasi kulit pisang kepok dan daun teh hijau menggunakan pelarut etanol 96%. Komponen formula SNEDDS (minyak kemiri : tween 80 : PEG 400) perbandingan 1:6:1; 1:7:1 dan 1:8:1. Orientasi ekstrak yang ditampung dalam sistem antara 100-500 mg. SNEDDS dengan loading ekstrak maksimal didispersikan dalam basis lotion kemudian dilakukan pecampuran dengan variasi kecepatan pencampuran (mortir, homogenizer kecepatan 500 dan 1000 rpm). Pengamatan sifat fisik dan kimia lotion meliputi viskositas, pH, daya sebar dan daya lekat. Analisa statistik menggunakan One Way Anova. Pengujian lotion dilakukan selama 12 hari dan data dianalisa menggunakan Paired T-Test. Hasil analisa statistik menunjukkan bahwa variasi kecepatan pencampuran berpengaruh signifikan terhadap daya sebar dan daya lekat, namun tidak berpengaruh terhadap viskositas dan pH lotion. Homogenizer dengan kecepatan 1000 rpm merupakan metode terbaik untuk lotion nano ekstrak etanol kombinasi kulit pisang kepok dan daun teh hijau karena memenuhi persyaratan sifat fisik dan kimia yang baik selama penyimpanan.
Review and Comparison of Food Drug Administration (FDA) and Medicines and Healthcare products Regulatory Agency (MHRA) on Good Manufacturing Practice (GMP) Implementation
Authors: Aziza Farida Nur
Published: April 2022

A government is responsible for ensuring public health and safety. One of the approaches is to establish a regulatory body that governs health-related items such as pharmaceuticals and other human health-related products. These regulatory bodies exist to ensure that goods satisfy high standards of quality, safety, and efficacy. This article investigates several aspects of regulatory bodies' regulation and Good Manufacturing Practice (GMP) standards controlled by two regulatory organizations, the Food and Drug Administration (FDA) and the Medicines and Healthcare products Regulatory Agency (MHRA). Both regulatory agencies appear to have some items controlled and fairly specific product authorization guidelines. It is apparent that both regulatory authorities have some comparable notions in common when it comes to GMP implementation, product registration, mutual recognition agreements, and MoU implementation.
Penggunaan Lean Hospital Untuk Meningkatkan Efisiensi Pelayanan Resep Rawat Jalan RSU PKU Muhammadiyah Delanggu
Authors: Winarno Nurlaila , Marchaban Marchaban , Yuniarti Endang
Published: April 2022

Instalasi Farmasi merupakan pintu terakhir dalam pelayanan kesehatan di rumah sakit. Baik buruknya pelayanan di instalasi farmasi menentukan tingkat kepuasan pasien secara umum. Oleh karena itu instalasi farmasi selalu dituntut untuk meningkatkan mutu yang berfokus pada kepuasan pasien dengan cara mengeliminasi pemborosan (waste) yang terjadi dalam proses pelayanan. Pasien menunggu pelayanan untuk waktu yang lama merupakan waste. Adanya waste berupa waiting akan menurunkan tingkat kepuasan pasien terhadap pelayanan kefarmasian. Penelitian ini bertujuan untuk meningkatkan efisiensi pelayanan resep di depo farmasi rawat jalan dengan menurunkan waktu tunggu (lead time) menggunakan konsep lean hospital. Penelitian dilakukan dengan desain action research dengan pendekatan Partisipatory Action research (PAR). Gambaran proses pelayanan dipetakan dengan value stream mapping, gambaran adanya waste berupa waiting diperoleh dari  Focus Group Discussion (FGD) dengan petugas farmasi, dan pengukuran lead time dilakukan langsung di tempat penelitian. Perbaikan dilakukan dengan lean tools. Hasil penelitian setelah dilakukan perbaikan dengan konsep lean hospital terjadi peningkatan efisiensi pelayanan dilihat dari penurunan lead time dari 54’35” menjadi 39’23”. Pada pengukuran kepuasan pasien, secara keseluruhan pasien belum merasa puas terhadap pelayanan depo farmasi rawat jalan dengan nilai gap terbesar pada dimensi daya tanggap (responsiveness), kemudian diikuti dimensi berwujud (tangible), keandalan (reliability), empati (empathy) dan jaminan (assurance).
The Description of Knowledge of Type 2 Diabetes Mellitus Patient Measured by Simplified Diabetes Knowledge Scale Indonesia Version (SDKS-INA)
Authors: Maiisyah Perdani Adnin , Ikawati Zullies , Zainal Zainol Akbar
Published: April 2022

Knowledge of diabetes is the important determinant to practice the self-care thus, the therapy goals of diabetes achieved. The aim of the study is to assess the knowledge of type 2 DM patients using SDKS-INA. This research is an observational study, with data collected in the community of the Yogyakarta province from January - May 2020. The assessment of knowledge of type 2 DM patients was measured by Simplified Diabetes Knowledge Scale in Bahasa Indonesia 1 for the non-insulin user (SDKS-INA1) and SDKS-INA2 for insulin user. Ninety-six of the non-insulin user and 28 insulin user type 2 DM participated in this study. The percentage of non-insulin user type 2 DM patients with a high level of knowledge was 53.13%, while in those in insulin user was 60,70%. However, high knowledge level is not the intention to discontinue giving education. The knowledge level also should be assessed routinely as well as delivering sustainable diabetes education.
Kepuasan Pasien Ulkus Diabetik Yang Menjalani Outpatient Parenteral Antimicrobial Treatment di RSUP Dr. Sardjito Yogyakarta
Authors: Sembiring Elma Viorentina , Puspitasari Ika , Asdie Rizka Humardewayanti , Sinorita Hemi
Published: April 2022

Outpatient parenteral antimicrobial treatment (OPAT) merupakan pemberian terapi antimikroba parenteral tanpa rawat inap. Tujuan utama program OPAT adalah memungkinkan pasien memperoleh terapi antibiotik parenteral dengan aman dan efektif tanpa menjalani rawat inap. Penelitian ini bertujuan untuk mengetahui perbedaan biaya pemberian antibiotika parenteral dan kepuasan pasien antara pasien ulkus diabetik terinfeksi yang memperoleh pelayanan rawat inap dan rawat jalan (OPAT). Penelitian ini adalah penelitian kuasi ekperimental dengan pendekatan prospektif pada pasien ulkus diabetik di RSUP Dr. Sardjito. Pengambilan sampel dilakukan secara non probability sampling kuota yang dilakukan pada bulan September 2019 – September 2020. Kuesioner kepuasan pasien yang digunakan dalam penelitian ini ialah Patient Satisfaction Quetionare-18 (PSQ-18) versi bahasa Indonesia yang telah melalui uji validitas dan reabilitas. Uji Mann Whitney dilakukan untuk mengetahui perbedaan kepuasan pasien antara kedua kelompok. Subjek penelitian dalam penelitian ini sebanyak 15 pasien pada kelompok OPAT dan 15 pasien pada kelompok kontrol (rawat inap). Pada penelitian ini didapatkan nilai rata-rata kepuasan pasien terhadap pelayanan OPAT dan control adalah 4,66  ± 0,09 dan 4,69 ± 0,08. Tidak terdapat perbedaan bermakna antara tingkat kepuasan pasien yang mendapatkan pelayanan OPAT dengan pelayanan rawat inap (p = 0,817).
Evaluasi pelaksanaan responsi praktikum Biokimia Farmasi kurikulum 2017 dengan soal UKAI-like model CBT
Authors: Hermawan Adam , Jenie Riris Istighfari , Rumiyati Rumiyati , Kristina Susi Ari
Published: April 2022

Metode computer based testing (CBT) dengan tipe soal multiple choice questions (MCQs) telah dilakukan untuk evaluasi pembelajaran pendidikan tinggi Farmasi. Evaluasi pembelajaran praktikum Biokimia Farmasi di tahun 2017 dan 2018 telah dilakukan dengan format CBT dengan tipe soal mirip UKAI (UKAI-like). Meskipun demikian belum pernah dievaluasi persepsi mahasiswa terhadap pelaksanaan responsi. Pada penelitian ini, selain dilakukan penilaian kemampuan kognitif, dilakukan juga evaluasi terhadap persepsi mahasiswa terhadap CBT dengan model UKAI-like. Sebanyak 214 mahasiswa Farmasi UGM semester II tahun akademik 2018/2019 terlibat dalam studi ini. Mahasiswa mengerjakan 30 soal tipe MCQs mirip UKAI dengan total waktu mengerjakan 20 menit. Ada 3 capaian pembelajaran mata kuliah (CPMK) untuk mata praktikum yang diukur yaitu pemahaman prinsip, pemahaman cara kerja serta kemampuan mengaplikasikan hasil praktikum. Persepsi dan penerimaan mahasiswa terhadap metode CBT untuk evaluasi pembelajaran praktikum diukur dengan kuesioner. Persentase CPMK praktikum menunjukkan hasil yang merata untuk ketiga jenis CPMK yaitu berada pada rentang 60%. Selain itu mahasiswa juga setuju bahwa metode CBT dapat diterima untuk evaluasi praktikum. Meskipun demikian, mahasiswa merasa bahwa soal responsi cukup sulit dan mengeluhkan terbatasnya waktu responsi.
Pengaruh Medication Therapy Management Terhadap Kepatuhan, Outcome Klinik dan Kualitas Hidup Pasien Diabetes Mellitus
Authors: Purwantiningsih Dyah , Yasin Nanang Munif , Kristina Susi Ari
Published: April 2022

Sebagian besar penderita Diabetes Mellitus (DM) belum memahami dengan benar pengobatan yang dijalaninya. Ketidakpatuhan dan ketidakpahaman pasien dalam menjalankan terapi merupakan salah satu penyebab kegagalan terapi. Penelitian ini bertujuan untuk melihat pengaruh Medication Therapy Management (MTM) terhadap tingkat kepatuhan, outcome klinik dan kualitas hidup pasien DM peserta Program Rujuk Balik (PRB). Rancangan penelitian ini menggunakan kuasi-ekperimental, dengan desain penelitian pretes-posttes with control group. Bentuk intervensi berupa layanan farmasi berbasis MTM. Subyek penelitian yaitu pasien DM peserta PRB di Kabupaten Sragen yang masuk kriteria inklusi. Instrumen yang digunakan adalah pill count, GDP dan DQLCTQ. Analisis data menggunakan uji Mann-Whitney atau T-test. Dari total 106 responden terbagi menjadi dua yaitu 55 responden kelompok kontrol dan 51 responden kelompok intervensi. Setelah dilakukan intervensi berupa layanan farmasi berbasis MTM menunjukkan adanya peningkatan kepatuhan pasien sebesar 5,76±9,17 (p=001), peningkatan outcome klinik berupa penurunan GDP sebesar 26,61±42,04 (p=0,010), dan  peningkatan kualitas hidup pasien sebesar 2,71±4,83 (p=0,018). Intervensi berupa layanan farmasi berbasis MTM dalam penelitian ini memperbaiki semua aspek variabel yang diteliti.
Psychometric Properties of Indonesian HEXACO-100: A Facet Level Analysis
Authors: Sugiarto Ardi Pratama , Sahrah Alimatus , Anwar Anwar
Published: April 2022

The HEXACO personality model is a six-dimensional personality model that is partially independent from the Big Five personality model (Zettler et.al., 2020). Measurement using the HEXACO Personality Inventory-Revised, its sixth dimension, Honesty-Humility, can capture previously unexplored images of personality. This study aims to adapt the HEXACO Personality Inventory-Revised 100 items version (HEXACO-100) into the Indonesian language and examine its psychometric properties. A purposive sample of 605 participants responded to Indonesian HEXACO-100 (67,2% female; mean age: 25,1 years). The result showed that all six factors have good alpha reliability (all factors α > .7), and the exploratory factor analysis and correlation analysis between the dimensions support the validity of the six-dimensional personality model. It can be concluded that this study successfully adapted the HEXACO-100 personality inventory into the Indonesian language, strengthens the existence of a six-dimensional personality model in Indonesia, and underlines that the HEXACO personality inventory is a useful and reliable personality inventory for investigating personality structure in cross-cultural settings.
Pengembangan Daftar Arsip Inaktif untuk Simplikasi Monitoring Penyusutan Arsip di Departemen Manajemen FEM IPB
Authors: Faridah Farhah
Published: April 2022

Depreciation of archives is the activity of reducing the number of archives by transferring inactive archives from processing to archiving unit, destruction of archives that have no useful value, and submission of static archives to archiving institutions (UU Nomor 43 tahun 2009). At each stage an archive list is required. At the stage when it has become an inactive archive, a list of inactive archives must be made with a column referring to article 44 of PP No. 28, 2012. This study aimed to describe the efficiency, ease of archive search, and monitoring archive depreciation with the development of existing inactive archive lists through the addition columns as needed for archival depreciation. Data were obtained through observations, interviews, and questionnaires. The development of inactive archive lists included archive management and availability of archiving human resources, implementation of archiving regulations, arrangement of inactive archives and services, development of inactive archive lists, implementation and services. The constraint of existing inactive archives list is unable to monitor the depletion of the next stage of the archives. The development of new inactive archives list can be retrieving archives as well as monitoring the depletion of archives, increasing the effectiveness and efficiency of work.
Memori dalam Lagu-Lagu: Memahami Pengelolaan Arsip Musik Populer di Indonesia
Authors: Darajat Irfan Rizky , Waluyo Waluyo
Published: April 2022

This article examines the role of information institutions in Indonesia in the management of Indonesia's popular music archives through a series of interviews and observations on previous research related to the institution. Music is an important cultural form for society. The music that developed in the community reflected the development of culture in a nation. The research was conducted on state-owned information institutions such as the National Archives of the Republic of Indonesia, the National Library of the Republic of Indonesia, Lokananta, and independent community institutions, namely Irama Nusantara. This study intends to explore how each of these information institutions obtains and manages archives related to Indonesian popular music. The way in which each information agency obtains, collects, and manages archives of Indonesian popular music will provide an overview of how these institutions understand or interpret Indonesian popular music archives and the challenges in managing them. It will also provide an overview of the importance of managing Indonesia's popular music archives as an ongoing work between state information agencies, popular music fan communities, and the music industries.
Open access secara fulltext terhadap koleksi karya ilmiah di Perpustakaan Fakultas Ilmu Budaya Universitas Gadjah Mada
Authors: Rahmaniati Kurnia
Published: April 2022

Peran dari perpustakaan merupakan media penghubung bagi pemustaka untuk mendapatkan koleksi yang dikelola oleh perpustakaan guna memenuhi kebutuhan informasinya. Koleksi karya ilmiah meliputi skripsi, tesis, disertasi, laporan penelitian dan tugas akhir. Adapun tampilan penyajian koleksi karya ilmiah dalam bentuk digital bisa diihat sebagian informasi (judul, pendahuluan, kesimpulan, daftar pustaka) saja, adapula yang bisa dilihat secara fulltext. Makalah ini memaparkan secara deskriptif open access secara full text terhadap koleksi karya ilmiah di Perpustakaan Fakultas Ilmu Budaya Universitas Gadjah Mada. Pengumpulan data dilakukan dengan metode observasi pada website digilib.fib.ugm.ac.id. Analisis data menggunakan analisis SWOT (Strengths, Weaknesses, Opportunities, Threats). Manfaat penulisan makalah ini untuk memberi gambaran bagi pemustaka, perpustakaan baik dari luar dan dalam perpustakaan Fakultas Ilmu Budaya Universitas Gadjah Mada, mengenai kelebihan, kekurangan, peluang dan ancaman open access secara fulltext terhadap koleksi karya ilmiah di Perpustakaan Fakultas Ilmu Budaya Universitas Gadjah Mada
Kompetensi Pustakawan dalam tata kelola jurnal elektronik
Authors: Junandi Sri Junandi , Tri Prabowo Thoriq
Published: April 2022

Kajian ini bertujuan untuk menjelaskan dan mengetahui: (1) kompetensi Pustakawan dalam ekosistem digital; (2) deskripsi kegiatan tata kelola jurnal elektronik “best practice” Pustakawan; (3) tantangan Pustakawan sebagai manajer penerbitan jurnal elektronik; dan (4) upaya Pustakawan sebagai produsen pengetahuan. Sumber data kajian ini adalah studi literatur. Analisis data dilakukan secara deskriptif-kualitatif. Hasil kajian ini menunjukkan bahwa Pustakawan perlu melakukan peran kolaborasi tata kelola jurnal ilmiah dalam peningkatan perannya untuk menjadi produsen pengetahuan. Dalam berkolaborasi, Pustakawan dituntut memiliki kompetensi tata kelola jurnal ilmiah yang memadai seperti mampu mengelola naskah, mengelola publikasi ilmiah, mengemas produk pengetahuan, berkomunikasi, dan inovatif dalam layanan publikasi di Perpustakaan. Sebagai rekomendasi, lembaga pembina Pustakawan dan asosiasi profesi Pustakawan perlu mengkonsep kebijakan nasional dan mengadvokasi tetang pentingnya kegiatan tata kelola jurnal ilmiah untuk peningkatan karir Pustakawan dan praktisi Perpustakaan.