bluuebunny/crossref_metadata_2025 huggingface dataset:
A Global Study on the Correlates of Gross Domestic Product (GDP) and COVID-19 Vaccine Distribution
Authors: Basak Palash , Abir Tanvir , Al Mamun Abdullah , Zainol Noor Raihani , Khanam Mansura , Haque Md. Rashidul , Milton Abul Hasnat , Agho Kingsley Emwinyore
Published: February 2022

This study aimed to explore the association between the GDP of various countries and the progress of COVID-19 vaccinations; to explore how the global pattern holds in the continents, and investigate the spatial distribution pattern of COVID-19 vaccination progress for all countries. We have used consolidated data on COVID-19 vaccination and GDP from Our World in Data, an open-access data source. Data analysis and visualization were performed in R-Studio. There was a strong linear association between per capita income and the proportion of people vaccinated in countries with populations of one million or more. GDP per capita accounts for a 50% variation in the vaccination rate across the nations. Our assessments revealed that the global pattern holds in every continent. Rich European and North-American countries are most protected against COVID-19. Less developed African countries barely initiated a vaccination program. There is a significant disparity among Asian countries. The security of wealthier nations (vaccinated their citizens) cannot be guaranteed unless adequate vaccination covers the less affluent countries. Therefore, the global community should undertake initiatives to speed up the COVID-19 vaccination program in all countries of the world, irrespective of their wealth.
Ecological and Health Risk Assessment of Potential Toxic Elements from a Mining Area (Water and Sediments): The San Juan-Taxco River System, Guerrero, Mexico
Authors: Salcedo Sánchez Edith Rosalba , Martínez Juan Manuel Esquivel , Morales Manuel Martínez , Talavera Mendoza Oscar , Alberich María Vicenta Esteller
Published: February 2022

The San Juan-Taxco River system is situated in the Taxco mining district, which is a well-known international producer of silver, jewelry and precious metal handicrafts. The population and biota in the area have been affected by inappropriate disposal of anthropogenic activities that pollute the hydric resources and threaten their health and sustainability, since the inhabitants use the groundwater and river water for human consumption, domestic water supply and irrigation. This study was conducted to assess the pollution in the river system, human health implications and ecological risk in the aquatic environment (groundwater, surface water and superficial sediment). This evaluation was done on the base of hydrochemical, textural, mineralogical and geochemical analysis supported by calculation of human health risk using chronic daily intake (CDI), hazard quotient (HQ) and hazard index (HI) with environmental and geochemical indices for ecological risk evaluation. The health risk assessment indicated increasing non-health carcinogenic risk to the exposed population to the river water and dug wells (HI > 1), and thus, these resources are not recommended for human consumption, domestic activities and prolonged ingestion. The results demonstrated a high degree of pollution due to toxic elements and geochemical indices. The Pollution Load Index indicated potential risk that will cause harmful biological effects in the riverine environment.
Design of Desanding Facilities for Hydropower Schemes Based on Trapping Efficiency
Authors: Paschmann Christopher , Vetsch David F. , Boes Robert M.
Published: February 2022

Turbine wear caused by hydro-abrasion due to suspended sediment in the turbine water has a negative impact on the power production and revenue of hydropower schemes. Efficiency of desanding facilities that reduce suspended sediment load ahead of turbines is key to limiting hydro-abrasion. Existing facilities built according to common design approaches often show lack of performance, in particular under non-ideal site-specific inlet and outlet conditions. Consequently, a new design concept that allows for the optimized design of desanding facilities at hydropower schemes has been developed based on prototype field measurements and CFD modeling. The effects of facility layout and components, such as tranquilizing racks, transition zone and outflow weir and related design parameters on the flow field and involved particle settling have been investigated in a comprehensive numerical model study. Hence, length adjustment terms were deduced from resulting changes in trapping efficiency, which allow for the estimation of the required basin length and an optimized facility layout. Compared to design approaches considering linear settling trajectories of sediment particles, the proposed procedure leads to longer settling basins in general and thus to increased trapping efficiencies of desanding facilities. Furthermore, the findings about the effect of specific facility components may allow for the optimisation of existing desanding facilities in an economical way.
Experiment and Electro-Thermo-Chemical Modeling on Rapid Resistive Discharge of Large-Capacity Lithium Ion Battery
Authors: Doh Chil-Hoon , Ha Yoon-Cheol , Eom Seung-Wook , Yu Jihyun , Choe Seon-Hwa , Kim Seog-Whan , Choi Jae-Won
Published: February 2022

Heat generation and temperature of a battery is usually presented by an equation of current. This means that we need to adopt time domain calculation to obtain thermal characteristics of the battery. To avoid the complicated calculations using time domain, ‘state of charge (SOC)’ can be used as an independent variable. A SOC based calculation method is elucidated through the comparison between the calculated results and experimental results together. Experiments are carried for rapid resistive discharge of a large-capacitive lithium secondary battery to evaluate variations of cell potential, current and temperature. Calculations are performed based on open-circuit cell potential (SOC, T), internal resistance (SOC, T) and entropy (SOC) with specific heat capacity.
Mitigating Metal-dissolution in a High-voltage 15 wt% Si-Graphite‖Li-rich Layered Oxide Full-Cell Utilizing Fluorinated Dual-Additives
Authors: Kim Jaeram , Kwak Sehyun , Pham Hieu Quang , Jo Hyuntak , Jeon Do-Man , Yang A-Reum , Song Seung-Wan
Published: February 2022

Utilization of high-voltage electrolyte additive(s) at a small fraction is a cost-effective strategy for a good solid electrolyte interphase (SEI) formation and performance improvement of a lithium-rich layered oxide-based high-energy lithium-ion cell by avoiding the occurrence of metal-dissolution that is one of the failure modes. To mitigate metal-dissolution, we explored fluorinated dual-additives of fluoroethylene carbonate (FEC) and di(2,2,2-trifluoroethyl)carbonate (DFDEC) for building-up of a good SEI in a 4.7 V full-cell that consists of high-capacity silicon-graphite composite (15 wt% Si/C/CF/C-graphite) anode and Li1.13Mn0.463Ni0.203Co0.203O2 (LMNC) cathode. The full-cell including optimum fractions of dual-additives shows increased capacity to 228 mAhg−1 at 0.2C and improved performance from the one in the base electrolyte. Surface analysis results find that the SEI stabilization of LMNC cathode induced by dual-additives leads to a suppression of soluble Mn2+-O formation at cathode surface, mitigating metal-dissolution event and crack formation as well as structural degradation. The SEI and structure of Si/C/CF/C-graphite anode is also stabilized by the effects of dual-additives, contributing to performance improvement. The data give insight into a basic understanding of cathode-electrolyte and anode-electrolyte interfacial processes and cathode-anode interaction that are critical factors affecting full-cell performance.
Normas de papel
Authors: Parada Silva Juan Alexis , Rivera Gómez Andrés Felipe
Published: February 2022

Con el presente texto se pretende hacer un ejercicio reflexivo en torno a los nuevos retos que debe cumplir la ética personal y social a partir de las normativas de papel, las cuales emergen a raíz de la consolidación de una cultura del incumplimiento de las reglas en nuestro contexto latinoamericano y le hacen mucho daño a los individuos en los diferentes escenarios sociales. Para tal efecto, se inicia haciendo un análisis sobre la corrupción como fenómeno ejemplar que afecta el cumplimiento de las normas. Posteriormente, se aborda el problema referido a la violación de la norma y la disonancia cognitiva, la cual es un conflicto mental que surge cuando existe un desacuerdo entre las actuaciones y las creencias de los individuos, por lo general, éstas tienden a contradecirse. Finalmente, se trae a colación, la situación de que los tres elementos anteriores nos conllevan a repensar la vida desde una ética personal y social.
Especificación de una plataforma de codiseño basada en dsp/fgpa para la implementación de aplicaciones especificadas en simulink
Authors: Marín Jorge Iván , López Alexander , Quintero Jhon James
Published: February 2022

Se presenta la especificación del diseño de una arquitectura para el codiseño de aplicaciones de tratamiento digital de señales que parte de la especificación del sistema modelado en Simulink de Matlab. La arquitectura está compuesta por un DSP de punto fijo y una FPGA. Se construyó un traductor o parser que traduce un modelo de Simulink a sus funciones equivalentes en lenguaje C y entidades en VHDL, que son posteriormente compiladas y descargadas al DSP y FPGA, respectivamente. Adicionalmente, fue necesario construir un sistema o kernel de planificación de la ejecución de las tareas y la comunicación entre entidades hardware/software. Se detalla el modelo del sistema, y los diseños del kernel, hardware y parser.
Transformada wavelet y máquinas de soporte vectorial para la identificación de arritmias
Authors: Tovar-Salazar Diego Alejandro , Orozco-Naranjo Alejandro José , Muñoz-Gutiérrez Pablo Andrés , Murillo-Wills Héctor , Granada Javier Alejandro
Published: February 2022

Se presentan varios conjuntos de extracción de características de latidos normales y latidos de cuatro tipos de arritmias cardíacas, usando la transformada wavelet. Un grupo de conjuntos elegidos aleatoriamente, fueron utilizados para determinar los parámetros óptimos de la función núcleo polinomial (C y d) y de la función núcleo de base radial (C y gamma), que arrojaran los mejores resultados de clasificación para las máquinas de soporte vectorial. A partir de estos parámetros óptimos se realizaron pruebas de clasificación con todos los conjuntos de entrenamiento y se obtuvo un porcentaje de error de validación del 2.93% para una máquina de soporte vectorial con función núcleo de base radial, 11.72% con un clasificador Bayesiano y 3.63% con un perceptrón multicapa. Con el fin de reducir el porcentaje de error de validación, se aplicó la técnica de análisis por componentes principales para la selección efectiva de características y para reducir la dimensionalidad de los vectores de características de cada conjunto de entrenamiento. Las máquinas de soporte vectorial evaluadas con estos nuevos conjuntos de entrenamiento,  fueron más consistentes y presentaron siempre un porcentaje de error de validación menor, logrando un porcentaje de error de validación del 1.93%, el clasificador Bayesiano mejoró sustancialmente su capacidad de clasificación en la mayoría de casos, mientras que el perceptrón multicapa no fue muy susceptible a la selección efectiva de características y en algunos casos mejoró y en otros no.
Evaluación de la actividad antimicrobiana de los extractos de la planta Lippia origanoides h.b.k. Cultivada en el departamento del Quindío
Authors: Henao Julieth , Muñoz Leidy J. , Ríos-V Eunice , Padilla Leonardo , Giraldo-G. Germán Antonio
Published: February 2022

Se realizó el estudio fitoquímico preliminar de las hojas de Lippia origanoides H.B.K., llevado a cabo por varios métodos de extracción (percolación, soxhlet y lixiviación), utilizando solventes de diferentes polaridades como éter de petróleo, hexano, diclorometano y etanol. Se analizó el contenido de metabolitos secundarios, encontrando en los extractos polares flavonoides, taninos, glicósidos cardiotónicos, hidroquinonas y alcaloides, y en los extractos apolares, carotenoides, glicósidos cardiotónicos y esteroles. La actividad antimicrobiana de los extractos polares y apolares se evaluó por el método de difusión en disco (Kirby–Bauer) modificado, utilizando bacterias Gram–negativas y Gram-positivas, hongos y levaduras, observando que los extractos apolares mostraron actividad de inhibición del crecimiento de los microorganismos evaluados, mientras que los extractos polares no mostraron actividad frente a los mismos microorganismos.
DAMPAK KERUSAKAN SUMBER DAYA ALAM AKIBAT PENAMBANGAN BATUBARA DI NAGARI LUNANG, KECAMATAN LUNANG SILAUT, KABUPATEN PESISIR SELATAN, PROVINSI SUMATERA BARAT
Authors: Afrianti Suratni
Published: February 2022

Penambangan batubara memberikan manfaat yang cukup besar terhadap peningkatan pembangunan daerah dan penyerapan tenaga kerja, sealin itu juga menberikan dampak terhadap terjadi perubahan kualitas lingkungan hidup baik lingkungan fisik, kimia, biologi maupun sosial ekonomi dan budaya masyarakat. Metode pegumpulan data ini adalah dengan mengumpulkan data skunder dari Dokument UKL/Upl, Review jurnal, buku dan tulisan ilmiah lainnya kemudian di deskriptifkan menjadi sebuah tulisan, dimana dari analisis tersebut menggambarkan bahwa tambang batubara terutama tambang terbuka akan menimbulkan dampak terjadinya perubahan bentang alam, erosi tanah, polusi udara dan air serta dampak terhadap keanekaragaman hayati setempat. Dampak dari perubahan tersebut dapat bersifat positif yang menguntungkan masyarakat tetapi juga dapat menimbulkan dampak negatif yang menurunkan kualitas lingkungan hidup.
Erken Çocukluk Eğitiminde Mesleki Gelişim ve Dokümantasyonu: Öğretmen Portfolyosu
Authors: HAZAR Ramle Gül , YILMAZ Arif
Published: February 2022

Eğitim kalitesine ilişkin beklentileri karşılamada öğretmen mesleki gelişiminin önemi dikkate alındığında, öğretmen mesleki gelişiminin etkililiğine ilişkin yaklaşımların ve gelişimi destekleyecek araçların irdelenmesinin gerekli olduğu düşünülmektedir. Erken çocukluk eğitiminde mesleki gelişim, öğretmenlerin çocuk gelişimi bilgisi, çocuklar ve ebeveynlerle etkili iletişim kurma gibi alana özgü yeterlilikleri geliştirmelerini gerektirir. Erken çocukluk eğitiminin kalitesi, eğitimcilerinin mesleki yeterliliklerini geliştirmek üzere etkili mesleki gelişim çalışmaları gerçekleştirmelerine bağlıdır. Alanyazın geleneksel mesleki gelişim çalışmalarını etkililikten uzak olarak değerlendirirken, öğretmenlerin ihtiyaçlarına hitap eden ve sınıflarında değişikliklere yol açacak etkili mesleki gelişim çalışmalarının niteliklerine odaklanmıştır. Bu doğrultuda, etkili mesleki gelişim çalışmalarının araştırma temelli olması, öğrenen çıktılarına odaklanması, iş birliği fırsatları sunması, okul temelli uygulamalar içermesi, öğretmenlerin karar verme süreçlerine dahil olması, kişiye ve bağlama özgü içeriğe sahip olması ve yetişkin eğitimi prensiplerine dayanması gerektiği belirtilmektedir. Etkili mesleki gelişim çalışmaları, öğretmenlerin üstbilişsel bilgi geliştirmelerini destekler ve kendi mesleki ilerlemelerine ilişkin sorumluluk almalarını sağlayarak onları aktif bir rolde konumlandırır. Öğretmen portfolyosu, etkili mesleki gelişimin belirtilen boyutlarına zemin oluşturan bir mesleki gelişim aracı olarak karşımıza çıkmaktadır ve mesleki gelişim sürecini tanımlama ve yönetme, öğretimi geliştirme, performans değerlendirmesi, eylem araştırmaları yürütme ve mesleki yeterlikleri karşılama düzeyini gösterme için olanaklar sunar. Erken çocukluk eğitimcilerinin kendi mesleki gelişimlerinde aktif bir rol almalarını destekleyecek etkili bir araç olarak öğretmen portfolyosu geliştirmeleri, mesleki mesleki yeterliliklerini güçlendirecektir. Bu çalışmanın amacı, erken çocukluk eğitiminde öğretmen mesleki gelişimini, etkili mesleki gelişim bağlamında ele almak ve bir mesleki gelişim aracı olarak öğretmen portfolyosunu incelemektir. Bu çalışma, ilgili alanyazına başvurularak ve öğretmen mesleki gelişimi ile dokümantasyonuna ilişkin alanyazın ve bu konuda yapılan çalışmalar taranarak derleme türünde hazırlanmıştır. Bu derleme çalışmasında, erken çocukluk eğitiminde öğretmen mesleki gelişimi için etkili mesleki gelişim ilkeleri incelenmiş, söz konusu ilkeler doğrultusunda mesleki gelişim aracı olarak öğretmen portfolyosunun rolü değerlendirilmiştir. Ayrıca erken çocukluk eğitimcileri için öğretmen portfolyosu geliştirme süreci ile hizmet öncesi ve hizmet içi mesleki gelişimde kullanımı açıklanmıştır.
ANTHROPOMETRIC PARAMETERS OF ILL NEONATES IN A NEONATAL CARE UNIT AT HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL
Authors: Mai Thi Thu Huong , Nguyen Thi Thanh Binh
Published: February 2022

Objectives: To evaluate anthropometric parameters in ill neonates admitted to Hue University of Medicine and Pharmacy Hospital; and to identify the maternal risk factors associated with low birth weight neonates. Materials and method: A cross-sectional descriptive study was carried out. A convenient sampling of 291 neonates admitted in the neonatal care unit of Hue University of Medicine and Pharmacy Hospital, Hue, Viet Nam, from April 2019 to March 2020. Results: The incidence of low birth weight and large for gestational age accounted for 26.8% and 3.1%, respectively. Preterm birth was the dominant causes of LBW neonates, accounting for 70.5% of LBW neonates. The average weight of neonates was 2885.5 ± 638 gram, the average length and head circumference was 48 ± 3.2 cm và 33 ± 1.9 cm, respectively. Anaemia was 11.7%. The maternal risk factors associated with low birth weight status in ill neonates were : maternal height < 145 cm (OR=2.5), birth interval < 24 months (OR=5.4), multiple pregnancy (OR=5.1, 95% CI: 1.8-14.5), anaemia (OR=2.1,) and pre-eclampsia (OR=4.6) with p<0.05. Conclusion: In our findings, 26.8% of neonates were LBW, 3.1% of neonates were large for gestational age. Maternal height, birth interval, multiple pregnancy, maternal diseases (anaemia, pre-eclampsia) are predictors of low birth weight status in ill neonates
EVALUATION OF THE TREATMENT RESULTS OF TEMPOROMANDIBULAR DISORDERS AT HO CHI CINH CITY HOSPITAL OF ODONTO-STOMATOLOGY
Authors: Phan Anh Chi , Luong Thi Thao Nguyen
Published: February 2022

Objectives: (1) To examine the clinical characteristics of a patient with temporomandibular disorders (TMD) at Ho Chi Minh City Hospital of Odonto-Stomatology; (2) To evaluate the treatment results of TMD of the above study subjects. Subjects - methods: Descriptive and prospective studies with clinical intervention, no control over 40 patients diagnosed with TMD and treated at the Special Treatment Department – Dental Hospital Ho Chi Minh City from July 2019 to March 2020. Results: Clinical characteristics of patients with TMD: ratio of women: men was 1.86: 1; focus on the age group 25-44. Headache symptoms accounted for the highest proportion: 77.5%, followed by pain in the jaw when moving and hearing joint sounds: 70.0%. The degree of TMD according to the history is moderate - severe, dominating up to 85.0%. On clinical examination before treatment: limit movement of the jaw when opening the mouth to a maximum of 45%, limit when moving the jaw: 55%; pain with jaw movement: 70%; synapse and dysfunction in temporal joint: 85.0%; pain in the joints when touching: 55.0%; muscle pain to the touch is 32.5%; occlusion grade I: 72.5% left and 85% right; classify the degree of TMD according to the Helkimo’s scale: medium level: 45.0%, light: 32.5%, heavy: 22.5%. Evaluation of treatment results for TMD: the main applied methods are: medicine, occlusal splints and occlusal adjustment. Treatment results after 1 week of the end of treatment and follow-up after 3 months improved in the proportion of patients with limited jaw movement, jaw movement pain, joint pain when palpation and muscle pain. palpation, dysfunction in temporal jaws with significant differences; percentage of patients with good response to treatment: 17.5%, average: 72.5% and bad: 10.0% at follow-up visit after 3 months. Conclusion: The TMD treatment results showed an improvement in symptoms and signs before and after treatment with significant differences.
ASSESSMENT OF PATIENT SATISFACTION OF OUT-PATIENT SERVICES AT SOME HEALTH CARE FACILITIES IN THUA THIEN HUE PROVINCE
Authors: Le Ho Thi Quynh Anh , Duong Quang Tuan , Nguyen Vu Thanh , Nguyen Thi Phuong Anh , Ngo Thi Mong Tuyen , Tran Thi Truc Ly , Nguyen Minh Tam
Published: February 2022

Patient satisfaction has been considered an important metric to measure and improve the quality of health care services. Aims: This study aimed to capture patient satisfaction of the quality of services and explore the disparities in patients’ satisfaction by different type of health facilities. Methods: A cross-sectional investigation was conducted in 886 participants following the guidelines of Ministry of Health on assessment of patients’ satisfaction of out-patient services with 5 main indices: the average patient satisfaction score (PSI), the average patient satisfaction percentage, comprehensive satisfaction index (CSI), percentage of continuing to utilize health services, and percentage of perceiving health care expectaion. Results: The PSI of outpatient services among all partcipants reached 3.75 out of 5 points, corresponding to a satisfaction percentage of 64.8%. Of which, the PSI on different attributes of healthcare settings varied from 3.69/5 (lowest for district-level health facilities) to 3.92/5 (highest for private health settings). CSI was at 13.5%, the percentage of continuing to utilize health services reached 96.2% and people perceived 81.5% of their expectation. Primary care facilities have lower levels of satisfaction than the provincial, central and private facilities (p<0.05). Conclusion: Robust efforts should be taken in investing the infrastructure and performance of primary care settings, and improving the administrative procedures of public health settings. Furthermore, local authority should pay attention to promote the awareness of community to availability of health services at primary care settings.
EVALUATION TREATMENT RESULTS REVERSIBLE PULPITIS BY BIODENTINE
Authors: Phan Anh Chi , Le Thi Thu Nga
Published: February 2022

Background: Reversible pulpitis is a pathological form of the pulp, if detected and treated in time, pulp can recover. For the treatment of pulp conservation, many materials have been developed and continuously improved: Calcium hydroxide, Calcium silicate, Mineral Trioxide Agregate Tricalcium Silicate (Biodentine... The purpose of this study is evaluating the treatment results reversible pulpitis by Biodentine. Materials and Methods: 62 teeths in 54 patients (> 15 years old) diagnosed reversible pulpitis meeting inclusion criterias were selected in the study and divided into 2 groups: The experimental group with Biodentine (31 teeths) and the control group with Ca(OH)2 (31 teeths) in alternating order (if one patient owns 2 teeths meeting inclusion criterias, each tooth put into each group). Patients were examinated, conducted treatment and evaluated for clinical changes (cold test, electrical test) and X-ray (evaluated after 6 months). Results: The overall success rate of the treatment on the whole sample after 6 months was 78.0%, specifically Biodentin group was 89.7% and Ca(OH)2 group was 66.7%
EVALUATING THE RESULT OF CONCURRENT CHEMORADIOTHERAPY FOR STAGE II-III ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Authors: Trinh Le Huy , Pham Anh Duc
Published: February 2022

Background: In many countries as well as some oncology centers in Vietnam, three-dimensional conformal radiation therapy (3D-CRT) plus chemotherapy has been the standard treatment in esophageal cancer. This study aimed at evaluating the clinicopathological characteristics and treatment results of patients who underwent concurrent chemoradiotherapy for stage II-III esophageal cancer at Hanoi Oncology Hospital. Method: Descriptive, retrospective study of 36 patients who underwent concurrent chemoradiotherapy for stage II-III esophageal cancer at Hanoi Oncology Hospital from June 2018 to December 2019. Results: Mean age was 57.4 years old. Ratio male:female = 17:1. Most tumors were ulcerated masses (56.4%). 77.8% had middle-third tumors. 75% were in stage IIIA, 25% in stage II. 90.9% improved symptoms of dysphagia. Complete response, partial response and stable disease rates were 33.3%, 55.6% and 8.3%, respectively. One patient had disease progression. Median progression free survival was 18.1 months. Early toxicities: esophagitis 41.7%, skin fibrosis 91.7%. Late toxicity: esophageal stricture 47.2%. Conclusions: 3D-CRT plus concurrent chemotherapy is effective in treating stage II, III esophageal cancer with acceptable toxicities.
SCREENING NATURAL PRODUCT COMPOUNDS FROM CLEISTOCALYX OPERCULATUS FOR PROTEIN TYROSINE PHOSPHATASE 1B INHIBITORY ACTIVITY BY USING MOLECULAR DOCKING METHOD
Authors: Nguyen Hong Nhung , Ta Thi Thu Hang , Vu Khanh Linh , Bui Thanh Tung
Published: February 2022

Background: Diabetes mellitus is a complex chronic disease. It is characterized by high level of glucose in the blood, caused by deficiency in insulin secretion from the β pancreatic’s cells or the operability of insulin. The protein tyrosine phosphatase 1B (PTP1B) catalyzes in order to remove of the phosphate group from the insulin receptor's phosphotyrosine, so it reduces the effects of insulin on target tissues. Therefore, inhibiting this enzyme is an effective method to treat diabetes mellitus. Cleistocalyx operculatus has been shown to be effective with the treatment of diabetes mellitus. Objectives: In this study, we evaluated the inhibitory effects of PTP1B enzyme of Cleistocalyx operculatus’s compounds by using molecular docking method. Materials and Methods: The protein tyrosin protease 1B structure was obtained from Protein Data Bank. Compounds were collected from the publication of Cleistocalyx operculatus and these structures were obtained from the PubChem database. Molecular docking was done by Autodock vina software. Lipinski Rule of Five is used to compare compounds with drug-like and non-drug-like properties. Pharmacokinetic parameters of potential compounds were evaluated using the pkCSM tool. Results: Based on previous publication of Cleistocalyx operculatus, we have collected 62 compounds. The results showed that there are 4 compounds have PTP1B inhibitory effect stronger than the positive control including abieta-7,13-diene, kaempferol, quercetin, luteolin. Analysising Lipinski rule of five showed that all 4 compounds have drug-likeness propieties. Moreover, predict ADMET showed that these compounds have good intestinal absorption and low toxicity. Conclusion: Therefore, kaempferol, quercetin, luteolin and abieta-7,13-diene may be potential natural product compound for diatetes treatment.
EFFICACY OF AZITHROMYCIN COMBINED WITH ADAPALENE IN TREATING MODERATE AND SEVERE ACNE VULGARIS
Authors: Hoang Thi Hoai Phuong , Nguyen Thi Tra My , Nguyen Thi Thanh Phuong , Mai Ba Hoang Anh , Le Thi Thuy Nga , Tran Ngoc Khanh Nam
Published: February 2022

Aims: Evaluating the effectiveness of Azithromycin combined with Adapalene in treating moderate and severe Acne Vulgaris. Methodology: 38 patients diagnosed moderate and severe Acne vulgaris at Dermatology clinic, Hue University of Medicine and Pharmacy Hospital from May 2017 to March 2018, were examined and treated for 3 times at 4 weeks’ interval. Results: After 8 weeks of treatment, comedones, inflamed lesions and total lesions decreased in 56.8%, 79.7% and 65.6%, respectively. Lesions decreased statistical significantly (p < 0.0001). Qualitative evaluation showed 89.6% good and average results and over 90% patients satisfied with treatment. 4 in 38 patients have some kinds of side effects such as abdominal pain, nausea, vomit and diarrhea. Conclusions: Azithromycin combines with Adapalene showed good results in treating moderate and severe Acne Vulgaris.
EVALUATION OF THE SUSCEPTIBILITY OF TRICHOMONAS VAGINALIS TO MELALEUCA QUINQUENERVIA ESSENTIAL OIL
Authors: Nguyen Thi Ha Trinh , Le Chi Cao , Ha Thi Ngoc Thuy , Ngo Thi Minh Chau , Ton Nu Phuong Anh
Published: February 2022

Trichomonosis is the most common non-viral sexually transmitted disease (STD) in the world. Due to the development of metronidazole-resistant isolates, therapeutic alternatives to 5-nitroimidazole are being investigated. T. vaginalis can be naturally infected with Mycoplasma hominis, Mycoplasma girerdii and Trichomonas vaginalis virus (TVV). Objective: 1) The essential oil from Melaleuca quinquenervia was used to test the anti-trichomonas activity. 2) Symbiosis was checked to determine whether there is any correlation between T. vaginalis – infected and T. vaginalis - free with esssential oil. Materials and methods: A total of 32 T. vaginalis isolates from Hue province subjected to susceptibility testing against essential oils by broth microdilution method. Polymerase chain reaction (PCR) was used to detect the presense of M. hominis and M. girerdii. TVV haboring protozoan was identified by total RNA extraction. Result: The M. quinquenervia essential oil showed antitrichomonal activity at the mean of MIC at 0.15 ± 0.07% after 24 hours and 0.09 ± 0.05% after 48 hours. There was no significant differences in MIC of essential oil to T. vaginalis-microorganisminfected and T. vaginalis-free. Conclusion: M. quinquenervia essential oil can be used as potential therapeutic natural resource for development of antitrichomonal drugs, to not only T. vaginalis-free isolates but also T. vaginalis-infected isolates.
Воєнно-наукове супроводження як основа управління повним життєвим циклом виробів зенітного ракетного озброєння
Authors: Зубарев Валерій Володимирович , Ланецький Борис Миколайович , Лук′янчук Вадим Володимирович , Ніколаєв Іван Михайлович , Єфімов Ігор Львович
Published: February 2022

Викладається системно-концептуальний під хід до воєнно-наукового супроводження як до основної складової управління повним життєвим циклом виробів зенітного ракетного озброєння, до яких належать зенітні ракетні системи і комплекси різного функціонального призначення. Показано, що воєнно-наукове супроводження має бути наскрізним і охоплювати усі стадії повного життєвого циклу від формування задуму до утилізації виробу. Сформульована мета наскрізного воєнно-наукового супроводження – досягнення необхідних значень тактико-технічних і експлуатаційно-технічних характеристик зенітної ракетної системи (комплексу) при оптимізації витрат на розробку, виробництво, експлуатацію і утилізацію виробу.
Випромінювання звуку циліндричним п’єзокерамічним гідроакустичним перетворювачем з динамічно керованими параметрами
Authors: Позднякова Ольга Миколаївна , Дерепа Анатолій Войткович , Ластівка Іван Олексійович , Лейко Андрій Олександрович , Дрозденко Олександр Іванович , Осадча Анастасія Костянтинівна
Published: February 2022

Запропонована схема побудови циліндричного п’єзокерамічного гідроакустичного перетворювача, параметрами якого можна динамічно керувати в процесі експлуатації за допомогою оперативної зміни амплітуд і фаз електричного збудження зовнішньої та внутрішньої асиметрично розміщених п’єзокерамічних оболонок перетворювача. Методом зв’язаних полів вбагатозв’язних областях розв’язана наскрізна задача випромінювання звуку таким перетворювачем та одержані аналітичні співвідношення для кількісної оцінки параметрів його акустичних, механічних і електричних динамічних полів.
Hirayama Disease: Review of Literature and Our Own Clinical Observations
Authors: Лихачев С.А. , Мальгина Е.В. , Брант Е.В. , Корбут Т.В. , Василевич Э.Н. , Науменко Д.В. , Рушкевич Ю.Н.
Published: February 2022

Приведенные в статье клинические наблюдения представляют собой различные варианты болезни Хираяма, протекающей с двусторонним или односторонним поражением верхних конечностей. Болезнь Хираяма (БХ) является редким непрогрессирующим неврологическим заболеванием, ассоциированным с поражением мотонейронов передних рогов спинного мозга при сгибании шейного отдела позвоночника. В настоящее время отмечается рост интереса и увеличение числа клинических описаний редкой формы мономелической амиотрофии (болезни Хираяма) в медицинских журналах, что может быть связано с распространенностью нейровизуализационных исследований и более широкого выполнения МРТ пациентам с дистальной амиотрофией. Диагностика БХ основывается на особенностях клинической картины, течения заболевания и дополняется специфичными для данной патологии МРТ-данными. «Золотым стандартом» диагностики БХ является МРТ шейного отдела позвоночника в положении сгибания. На данный момент этиотропного и патогенетического консервативного лечения не разработано. Возможны хирургическая коррекция или симптоматическая консервативная терапия. Приведенные в статье клинические наблюдения представляют собой различные варианты болезни Хираяма, протекающей с двусторонним или односторонним поражением верхних конечностей.

The clinical observations presented in the article represent various variants of Hirayama disease, which occurs with a bilateral or unilateral lesion of the upper extremities. Hirayama disease (HD) is a rare non-progressive neurological disease associated with damage to the motor neurons of the anterior horns of the spinal cord during flexion of the cervical spine. Currently, there is the increase of interest and the number of clinical descriptions of a rare form of monomyelic amyotrophy (Hirayama disease) in medical journals, which may be due to the prevalence of neuroimaging studies and more widespread MRI in patients with distal amyotrophy. The diagnosis of HD is based on the features of the clinical picture, the course of the disease, and it is supplemented by MRI data specific to this pathology. The “gold standard” for diagnostics of this pathology is MRI of the cervical spine in the flexion position. Currently, no etiotropic and pathogenetic conservative treatment has been developed. Surgical correction or symptomatic conservative therapy is possible.
Features of Management of Peripheral Arterial Disease of the Lower Extremities in Diabetes Mellitus
Authors: Мохорт Т.В.
Published: February 2022

Сахарный диабет - признанный фактор риска мультисосудистого поражения, развития полинейропатии, когнитивного снижения. Заболевания периферических артерий нижних конечностей (ЗПАНК) являются частым проявлением при сахарном диабете, определяя негативный прогноз. В обзоре рассмотрены современные подходы к ведению пациентов с ЗПАНК, включая особенности использования глюкозоснижающей терапии, гипотензивных и гиполипидемических препаратов с превентивной целью. Четко обоснована необходимость использования физических нагрузок, описаны возможности терапевтического лечения. Среди терапевтических опций сделан акцент на потенциальные преимущества использования актовегина, оказывающего мультимодальное действие.

Diabetes mellitus is a recognized risk factor of multi-vascular lesions, development of polyneuropathy, and cognitive decline. Diseases of the peripheral arteries of the lower extremities are a frequent manifestation in diabetes, determining a negative prognosis. In the review, there are considered modern approaches to the management of patients with diseases of the peripheral arteries of the lower extremities, including the features of the use of glucose-lowering therapy, antihypertensive and lipid-lowering drugs for preventive purposes. The necessity of using physical activity is clearly justified, and the possibilities of therapeutic treatment are described. Among the therapeutic options, the emphasis is placed on the potential benefits of using actovegin, which has a multimodal effect.
Mental Disorders in Patients with Arterial Hypertension
Authors: Протько Н.Н. , Патеюк И.В. , Милюк Н.С.
Published: February 2022

В статье описаны особенности психических расстройств у пациентов с артериальной гипертензией.

The article describes the characteristics of mental disorders in patients with arterial hypertension.
Sensorineural Hearing Loss during the COVID-19 Pandemic: What do We Know Today?
Authors: Саливончик Е.И.
Published: February 2022

Нейросенсорную тугоухость (НСТ) необходимо выделить как одно из клинических проявлений COVID-19. Прямой нейротропный эффект SARS-CoV-2, воспалительная реакция, цитокиновый шторм, цереброваскулярные нарушения, прием ототоксических препаратов, широко используемых в качестве лечения во время пандемии, могут способствовать возникновению внезапной НСТ при COVID-19. Выявление SARS-CoV-2 как этиологического фактора внезапной НСТ является основанием для выбора правильной стратегии лечения с целью максимального клинического выздоровления и сведения к минимуму побочных эффектов и осложнений. Традиционное использование глюкокортикостероидов в лечении НСТ при COVID-19 может представлять риск увеличения тяжести инфекции и вызывать задержку выведения вируса. Использование альтернативных методов лечения у пациентов с внезапной НСТ в случаях с COVID-19 может предотвратить такие нежелательные последствия. Применение кавинтона патогенетически обосновано при внезапной НСТ, обусловленной SARS-CoV-2, ввиду основных его эффектов. Кавинтон является нейропротектором, антиоксидантом, улучшает реологические свойства крови и микроциркуляцию, обладает антитромботическим действием, подавляет индукцию провоспалительных цитокинов (фактор некроза опухоли α, интерлейкин-1β и макрофагальный белок воспаления), тормозит индукцию воспалительных медиаторов в гладкомышечных клетках сосудов, эндотелии, макрофагах и эпителии, уменьшает гиперплазию неоинтимы и пролиферацию гладкой мускулатуры сосудов.

Sensorineural hearing loss (NSHL) should be identified as one of the clinical manifestations of COVID-19. The direct neurotropic effect of SARS-CoV-2, inflammatory response, cytokine storm, cerebrovascular disorders, use of ototoxic drugs, widely used as a treatment during the pandemic, can contribute to the occurrence of sudden NSHL in COVID-19. The identification of SARS-CoV-2 as an etiological factor of sudden NSHL is the base for choosing the right treatment strategy to maximize clinical recovery and minimize side effects and complications. The traditional use of corticosteroids in the treatment of NSHL in COVID-19 may pose a risk of increasing the severity of the infection and cause a delay in elimination of the virus. The use of alternative therapies in patients with sudden NSHL in cases with COVID-19 can prevent such undesirable consequences. The use of Cavinton is pathogenetically justified in sudden NSHL caused by SARS-CoV-2 due to its main effects. Cavinton is a neuroprotector, an antioxidant, which improves the rheological properties of blood and microcirculation, has antithrombotic effect, suppresses the induction of pro-inflammatory cytokines (tumor necrosis factor α, interleukin-1β, and macrophage protein of inflammation), inhibits the induction of inflammatory mediators in vascular smooth muscle cells, endothelium, macrophages and epithelium, and reduces neointima hyperplasia and proliferation of vascular smooth muscle.
Some Ideas how to Overcome the Post-Virus Syndrome of COVID-19
Authors: Цапаев В.Г. , Цапаева Н.Л.
Published: February 2022

Представлены данные о клинических проявлениях постковидного синдрома и его патофизиологических механизмах в аспекте энергетического метаболизма. Дано обоснование использования экзогенного креатинфосфата для коррекции нарушений клеточного энергетического метаболизма при постковидном синдроме. Приводятся результаты клинических исследований, подтверждающие целесообразность предлагаемого терапевтического подхода к коррекции последствий перенесенного COVID-19.

Clinical manifestations of the post-COVID syndrome and the accompanied metabolic disorders are presented in the article. The rationale of treatment with an exogenic phosphocreatine is given. The overview of clinical studies is presented to substantiate the feasibility of the proposed treatment approach.
Simulation Education in a Modern Multidisciplinary Clinical Medical Center
Authors: Абельская И.С. , Каминская Т.В. , Борушко О.С.
Published: February 2022

Публикация посвящена опыту организации и применения симуляционного обучения в медицине на базе высокотехнологичного многопрофильного клинического медицинского центра. Авторами отмечены современные подходы и темпы развития технологий в медицине, требующие от медицинского персонала быстрого и качественного приобретения мануальных навыков и развития клинического мышления с минимизацией лечебно-диагностических ошибок и безопасности для пациента. Подробно описана структура, оснащение симуляционного центра, реализуемые образовательные программы повышения квалификации и обучающих курсов, в том числе эксклюзивные, не имеющие аналогов в Республике Беларусь. Представленная модель образовательного симуляционного центра в высокотехнологичной, многопрофильной клинике позволяет признать ее эффективной и использовать при реализации программы модернизации системы здравоохранения и трансформирования постдипломного образования в Республике Беларусь.

The publication is devoted to the experience of organizing and applying the simulation training in medicine on the base of modern multidisciplinary clinical medical center. The authors distinguished modern approaches and rates of development of technologies in medicine, which requires medical personnel to acquire manual skills quickly and efficiently and develop clinical thinking with minimization of treatment and diagnostic errors providing safety for the patient. The structure is described in detail: equipment of the simulation center, educational programs for advanced training and training courses, including exclusive ones that have no analogues in the Republic of Belarus. The presented model of the educational simulation center in a modern multidisciplinary clinic allows us to recognize its efficiency and to use it in the implementation of the program of modernization of the healthcare system and transformation of postgraduate education in the Republic of Belarus.
Features of Skin Pathology in Liver Transplant Recipients
Authors: Музыченко А.П. , Руммо О.О.
Published: February 2022

Пациенты, перенесшие трансплантацию печени, подвержены высокому риску развития дерматологических осложнений по сравнению с общей популяцией в результате продолжительной иммуносупрессивной терапии. Ранняя диагностика и соответствующее лечение кожной патологии - важная составляющая клинического ведения реципиентов печеночного трансплантата.

Patients undergoing liver transplantation are at a high risk of dermatological complications compared to the general population as a result of long-term use of immunosuppressant. Their early recognition and appropriate treatment is an important component of the clinical management of liver transplant recipients.
Possibilities and Prospects for Using Calcipotriol in Dermatological Practice for Local Treatment of Psoriasis
Authors: Панкратов О.В.
Published: February 2022

Приведены данные о патогенезе псориаза и возможных направлениях его наружного лечения. Проведен анализ современного международного опыта использования кальципотриола - синтетического аналога 1,25-дигидрооксихолекальциферола - наиболее активного метаболита витамина D3 для местного лечения пациентов с вульгарным псориазом. Обсуждены возможности применения лекарственных средств кальципотриола в виде раствора, мази, а также комбинации кальципотриола и бетаметазона при местном лечении вульгарного псориаза. Предложено более широкое использование лекарственных средств на основе кальципотриола для местного лечения пациентов с вульгарным псориазом как в виде монотерапии, так и в комбинации с бетаметазоном, что позволит обеспечить высокую эффективность и безопасность терапии, повысить качество жизни пациентов, комплаентность лечения с более благоприятными фармакоэкономическими показателями.

The data on the pathogenesis of psoriasis and possible directions of its external treatment are presented. The analysis of modern international experience of using calcipotriol - a synthetic analogue of 1.25-dihydrooxycholecalciferol - the most active metabolite of vitamin D3 for local treatment of patients with psoriasis vulgaris was carried out. The possibilities of using calcipotriol drugs in the form of a solution, ointment, as well as a combination of calcipotriol and betamethasone in the local treatment of psoriasis vulgaris are discussed. A wider use of drugs based on calcipotriol for local treatment of patients with psoriasis vulgaris, both in the form of monotherapy and in combination with betamethasone, has been proposed, which will ensure high efficacy and safety of therapy, improve the quality of life of patients, and treatment compliance with more favorable pharmacoeconomic indicators.
Myelodysplastic Syndrome on the Background of Severe Hypothyroidism: Case Report and Literature Review
Authors: Песоцкая Л.А. , Щукина Е.С. , Опрятная Т.О.
Published: February 2022

Миелодиспластический синдром (МДС) - гетерогенная группа клональных заболеваний системы крови, возникающих вследствие мутации гемопоэтической стволовой клетки и характеризующихся цитопенией, как результатом неэффективного гемопоэза, признаками дисмиелопоэза и высоким риском трансформации в острый лейкоз. Более 80% пациентов c МДС - это люди старше 60 лет. В целом в Европе ежегодно диагностируют примерно 25 тыс. новых случаев. Учитывая неуклонное «старение» населения Европы, полагают, что число пациентов с МДС будет в ближайшие десятилетия лишь возрастать. Кроме того, признаки миелодисплазии могут выявляться в костном мозге или периферической крови не только при МДС, но и при других заболеваниях неклонального характера. Известна роль в гемопоэзе гормонов щитовидной железы, что не исключает развития дисмиелопоэза при гипотиреозе. Встатье приводятся классификация, клиника первичного МДС и клинический случай развития заболевания на фоне тяжелого гипотиреоза с особенностями течения МДС.

Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal diseases of the blood system arising from mutation of the hematopoietic stem cell and characterized by cytopenia as a result of ineffective hematopoiesis, the signs of dysmyelopoiesis, and a high risk of transformation into acute leukemia. More than 80% of MDS patients are over 60 years old. Approximately 25,000 new cases are diagnosed annually in Europe. Taking into account the aging of the European population, it is believed that the number of patients with MDS will only increase in the coming decades. Additionally, the signs of myelodysplasia can be detected in the bone marrow or peripheral blood, not only in MDS, but also in other non-clonal diseases. The role of thyroid hormones in hematopoiesis is known, which does not exclude the development of dysmyelopoiesis in hypothyroidism. The article presents the classification, the clinic of primary MDS, and the clinical case of the development of disease on the background of severe hypothyroidism with the features of the course of MDS.