bluuebunny/crossref_metadata_2025 huggingface dataset:
Three-dimensional evaluation of maxillary tooth movement in extraction patients with three different miniscrew anchorage systems: a randomized controlled trial
Authors: Zhang Liwen , Guo Runzhi , Xu Baohua , Wang Yue , Li Weiran
Published: December 2022

Objective

To compare the three-dimensional (3-D) movement of maxillary teeth in response to three common miniscrew anchorage systems in extraction patients with maxillary dentoalveolar protrusion.

Materials and methods

The study employed a randomized controlled single-blinded design with three arms. Thirty extraction patients who required maximum anchorage to retract maxillary anterior teeth were included and randomly allocated into three treatment groups: space closure with direct miniscrew anchorage and low crimpable hooks (DL group), indirect miniscrew anchorage and low crimpable hooks (IL group), and direct miniscrew anchorage and high crimpable hooks (DH group). Cone beam computed tomography (CBCT) images of all included patients were obtained immediately before (T0) and after (T1) space closure. The outcomes were 3-D positional changes of maxillary central incisor, lateral incisor, canine, second premolar, and first molar. The repeated measures analysis of variance with post hoc LSD test was used to evaluate differences among groups.

Results

A significant intrusion (− 1.34 mm; 95% CI, − 1.60 mm, 1.08 mm) and buccal (− 6.92°; 95% CI, − 8.67°, − 5.13°) and distal (4.90°; 95% CI, 3.75°, 6.04°) inclination of the maxillary first molars were observed in the DL group, compared to the other two groups. The mesial movement (− 0.40 mm; 95% CI, − 0.83 mm, − 0.03 mm) of the maxillary first molars was found in the IL group, while the DL (0.44 mm; 95% CI, 0.15 mm, 0.73 mm) and IL (0.62 mm; 95% CI, 0.28 mm, 0.96 mm) groups exhibited distal movement. In the DH group, the lingual inclination changes of maxillary central incisor (5.04°; 95% CI, 2.82°, 7.26°) were significantly lower, which is indicative of good lingual root torque control of the maxillary anterior teeth.

Conclusion

Three miniscrew anchorage systems produced significantly different 3-D maxillary tooth movement. The maxillary first molars were significantly buccally and distally inclined and intruded in patients using direct miniscrew anchorages with low crimpable hooks. Direct miniscrew anchorages with high crimpable hooks could help to achieve better lingual root torque control of the maxillary incisors.

Trial registration The trial was registered at www.chictr.org.cn (ChiCTR1900026960). Registered 27 October 2019.
Petrophysical characterization, BIB-SEM imaging, and permeability models of tight carbonates from the Upper Jurassic (Malm ß), SE Germany
Authors: Freitag Simon , Klaver Jop , Malai Iulian S. , Klitzsch Norbert , Urai Janos L. , Stollhofen Harald , Bauer Wolfgang , Schmatz Joyce
Published: December 2022

Tight carbonate rocks are important hydrocarbon and potential geothermal reservoirs, for example, in CO2-Enhanced Geothermal Systems. We report a study of outcrop samples of tectonically undeformed tight carbonates from the upper Jurassic “Malm ß” formation in Southern Germany near the town of Simmelsdorf (38 km NE of Nuremberg) to understand bulk petrophysical properties in relation to microstructure and to compare models for permeability prediction in these samples. We applied Archimedes isopropanol immersion, Helium pycnometry, mercury injection, gamma density core logging, and gas permeability measurements, combined with microstructural investigations and liquid metal injection (LMI-BIB-SEM). In addition, ultrasonic velocity was measured to allow geomechanical comparison of stratigraphically equivalent rocks in the South German Molasse Basin (SGMB). Results show only small variations, showing that the formation is rather homogeneous with bulk porosities below 5% and argon permeabilities around 1.4E−17 m2. The presence of stylolites in some of the samples has neither a significant effect on porosity nor permeability. Pores are of submicron size with pore throats around 10 nm and connected as shown by Mercury injection and Liquid Metal injection. Samples have high dynamic Young’s Modulus of 73 ± 5 GPa as expected for lithified and diagenetically overmature limestones. Moreover, no trends in properties were observable toward the faults at meter scale, suggesting that faulting was post-diagenetic and that the matrix permeabilities were too low for intensive post-diagenetic fluid–rock interaction. Petrophysical properties are very close to those measured in the SGMB, illustrating the widespread homogeneity of these rocks and justifying the quarry as a reasonable reservoir analog. Permeability prediction models, such as the percolation theory-based Katz-Thompson Model, Poiseuille-based models, like the Winland, the Dastidar, the capillary tube, and the Kozeny-Carman Models, as well as several empirical models, namely, the Bohnsack, the Saki, and the GPPT Models, were applied. It is shown that the capillary tube Model and the Saki Model are best suited for permeability predictions from BIB-SEM and mercury injection capillary pressure results, respectively, providing a method to estimate permeability in the subsurface from drill cuttings. Matrix permeability is primarily controlled by the pore (throat) diameters rather than by the effective porosity.
An optimized biofumigant improves pepper yield without exerting detrimental effects on soil microbial diversity
Authors: Tagele Setu Bazie , Kim Ryeong-Hui , Jeong Minsoo , Jung Da-Ryung , Lee Dokyung , Shin Jae-Ho
Published: December 2022

Background

Biofumigation is a non-chemical sustainable approach that reshapes soil microbiota to overcome challenges in way of continuous cultivation. However, the type and quantity of substrate have a significant impact on microbiota shifts and the subsequent success of biofumigation. Moreover, studies on the effects of biofumigant concentration in combination with fumigation duration on soil microbiota dynamics are very rare.

Research methods

We performed microcosm experiments to investigate how a biofumigant (Korean canola cultivar, HanRa) at various concentrations (0.5%, 1%, 2–4% w/w: biofumigant/soil) and fumigation periods (2–4 weeks) affects the soil bacterial and fungal communities. Subsequently, pot experiments employing two Korean canola cultivars (HanRa and YongSan) at 1% (w/w) were carried out.

Results

Illumina MiSeq analysis revealed that 2–4% biofumigant, regardless of incubation period, had a significant negative impact on microbial diversity and network complexity. In contrast, 1% biofumigant transformed the bacterial, fungal, and inter-kingdom networks into a highly connected and complex network without affecting microbial diversity. Bacillus, Clostridium, and Pseudomonas were the most highly stimulated bacterial genera in the biofumigated soils, whereas the abundance of Acidobacteria members was greatly reduced. The 2–4% amendments had substantially and more differentially abundant Fusarium than the 1%. Soil nutrition (e.g., pH, nitrate, ammonium, and exchangeable potassium), fruit yield, and weed suppression were enhanced in subsequent pot experiments. Of the nine soil chemical properties, phosphate and exchangeable potassium were the main factors influencing the microbial community assembly.

Conclusions

Optimized biofumigation-mediated increase in nitrate, ammonium, and potassium availability in the soil without causing any negative effects on soil microbial diversity indicates its potential as a preplant to improve crop productivity. This study contributes significantly to our understanding of how an optimal biofumigant can help ameliorate obstacles in continuous cropping.

Graphical Abstract
Using PICRUSt2 to explore the functional potential of bacterial community in alfalfa silage harvested at different growth stages
Authors: Wang Siran , Wang Yuxin , Liu Haopeng , Li Xinbao , Zhao Jie , Dong Zhihao , Li Junfeng , Kaka Niaz Ali , Nazar Mudasir , Shao Tao
Published: December 2022

Background

This study evaluated the effects of growth stage and storage time on fermentation characteristics, bacterial communities and their functionality in alfalfa (Medicago sativaL.) silage. Alfalfa was harvested at initial flowering (10–20% bloom, AL1) and full flowering (> 80% bloom, AL2) stages, respectively. The harvested alfalfa was ensiled in 15 L plastic silos. Triplicate silos were sampled after 1, 3, 7, 15, 30 and 60 days of ensiling, respectively. Fermentation products were analyzed on each sampling day. The bacterial communities and their functional potential after 3 and 60 days were analyzed by high-throughput sequencing technique and PICRUSt2 method.

Results

AL2 had better fermentation quality than AL1 with lower pH, ammonia nitrogen and butyric acid concentrations and higher lactic acid concentrations on day 60. AL2 had higher abundances ofWeissellaandLactobacillusafter 3 days, and lower abundances ofEnterobacterand Enterobacteriaceae on day 60 compared to AL1. In metabolic pathway analysis, ensiling promoted the carbohydrate and amino acid metabolism, and inhibited the signal transduction and membrane transport. In enzyme analysis, AL2 had lower abundances of nitrite reductase (NADH) and ornithine decarboxylase than AL1 on day 60. In phenotype analysis, AL2 had higher proportions of facultatively anaerobic and lower proportions of anaerobic, potentially pathogenic and gram negative than AL1 on day 60.

Conclusions

High throughput sequencing technique combined with PICRUSt2 can be successfully used to describe the changes of bacterial communities and their functionality in silage. This approach can improve our understanding of the silage microbiology to further regulate the fermentation products.

Graphical Abstract
A simple co-precipitation sorbent-based preconcentration method for the analysis of fungicides in water and juice samples by high-performance liquid chromatography coupled with photodiode array detection
Authors: Santaladchaiyakit Yanawath , Sirijan Anuchit , Wongchalee Methaporn , Phurimsak Chayakom , Baoulan Areebhorn , Gamonchuang Jirasak , Boontongto Tittaya , Vichapong Jitlada , Burakham Rodjana , Srijaranai Supalax
Published: December 2022

A magnesium hydroxide co-precipitation sorbent-based method in the presence of an anionic surfactant (e.g., sodium dodecylbenzenesulfonate) and high-performance liquid chromatography were used to preconcentrate and analyze fungicides in water and apple juice samples. The preconcentration procedure can be accomplished in a single step based on the co-precipitation of target fungicides and magnesium chloride in the presence of surfactant in a sodium hydroxide solution (pH 11) and a white precipitate gel was simply obtained after centrifugation. The property of precipitate phase was subsequently characterized using Fourier-transform infrared spectroscopy, scanning electron microscopy, and X-ray diffractometry. Under the optimum conditions, the developed method exhibited good sensitivity, with an enrichment factor of 11–18 and limits of detection of approximately 1–5 μg/L for water samples and 7–10 μg/L for apple juices. High reproducibility was achieved with a relative standard deviation of less than 11%, and a good recovery range of 72% to 120% was also obtained. The proposed method was shown to be a simple preconcentration procedure for concentrating fungicides in the samples investigated.
Estimating heat tolerance of buds in southeastern US trees in fire-prone forests
Authors: McClure Adam B. , Coates T. Adam , Hiers J. Kevin , Seiler John R. , O’Brien Joseph J. , Hoffman Chad M.
Published: December 2022

Background

Traits of mature trees, such as bark thickness and texture, have been documented to promote resistance or resilience to heating in fire-prone forests. These traits often assist managers as they plan and promote prescribed fire management to accomplish specific land management objectives. Species are often grouped together as pyrophobes or pyrophytes as a result of these features. Nonetheless, little is known about species-specific traits of other structures, such as bud diameter, length, mass, moisture content, and surface area, that might be related to heat tolerance. Many prescribed fires are utilized in the eastern United States to control regeneration of less desired species, which could apply a more mechanistic understanding of energy doses that result in topkilling mid-story stems. In this study, we investigated potential relationships between terminal bud mortality from lateral branches of midstory stems and species-specific bud features of six eastern US deciduous trees. Characterized at maturity as either pyrophytes or pyrophobes, each was exposed to different heat dosages in a laboratory setting.

Results

Bud diameter, length, mass, moisture content, and surface area differed by species. Bud percent mortality at the first heat flux density (0.255–0.891MJm−2) was highest for two pyrophobes, chestnut oak (Quercus montana Willd.) and scarlet oak (Quercus coccinea Münchh). For the second heat flux density (1.275–1.485MJm−2), bud percent mortality was highest for these species and red maple (Acer rubrum L.). Principal component analysis suggested that bud surface area and length differentiated species. Red maple, chestnut oak, and scarlet oak produced clusters of buds, which may explain their more pronounced bud mortality. Yellow-poplar (Liriodendron tulipifera L.) was also present in that cluster, suggesting that its unique bud architecture of pre-emergent leaves may have elicited responses most similar to those of the clustered buds.

Conclusions

Contrary to expectations, lateral buds of species regarded as pyrophytes at maturity displayed some of the highest values of bud percent mortality when heated at two heat flux densities generated in a laboratory. Their responses may be related to clustering of their lateral buds. Testing of additional species using these methods in a laboratory setting, and perhaps additional methodologies in the field, is warranted.
Which is a better management for vocal fold cyst: cold knife or laser resection?
Authors: Khafagy Ahmed G. , Askoura Anas , Kassamy Hany , Abdelgoad Ahmed A.
Published: December 2022

Background

The objective of the study is to compare the conventional microlaryngeal surgery and the CO2 laser in the treatment of cysts of vocal folds, regarding the postoperative quality of voice.

This study was conducted on 53 cases with vocal fold cysts. The cases were randomly allocated into two groups: group 1 (27 cases) was operated by the conventional technique, and group 2 (26 cases) was operated with CO2 laser microlaryngeal operation. At 3-month postoperative, evaluation was done by stroboscopic evaluation of vocal folds, grade of hoarseness, roughness, breathiness, asthenia, and strain (GRBAS) scale and Arabic version of Voice Handicap Index (VHI).

Results

The stroboscope assessment revealed that glottic closure was complete, symmetrical motion, the reappearance of the mucosal wave, normal amplitude, and periodicity in all patients. There is insignificantly different between either group as regards the postoperative scores on VHI and GRBAS scale.

Conclusion

There is insignificantly different when comparing laser to conventional microlaryngeal surgery for excision of vocal fold cysts regarding the quality of voice.
A mass budget and box model of global plastics cycling, degradation and dispersal in the land-ocean-atmosphere system
Authors: Sonke Jeroen E. , Koenig Alkuin M. , Yakovenko Nadiia , Hagelskjær Oskar , Margenat Henar , Hansson Sophia V. , De Vleeschouwer Francois , Magand Olivier , Le Roux Gael , Thomas Jennie L.
Published: December 2022

Since 1950 humans have introduced 8300 teragrams (Tg, 1012 g, millions of metric tons) of plastic polymers into the Earth’s surface environment. Accounting for the dispersal and fate of produced plastics and fragmented microplastics in the environment has been challenging. Recent studies have fueled debate on the global river budget for plastic transport to oceans, the sinking and beaching of marine plastics and the emission and deposition of atmospheric microplastics. Here we define a global plastics cycle and budget, and develop a box model of plastics cycling, including the fragmentation and transport of large and small microplastics (LMP, SMP) within coupled terrestrial, oceanic and atmospheric reservoirs. We force the model with historical plastics production and waste data, and explore how macroplastics, LMP and SMP propagate through the reservoirs from 1950 to 2015 and beyond. We find that considerable amounts of plastics reside most likely in the deep ocean (82 Tg), in shelf sediments (116 Tg), on beaches (1.8 Tg) and, as a result of marine emissions, in the remote terrestrial surface pool (28 Tg). Business as usual or maximum feasible reduction and discard scenarios show similar, 4-fold increases in atmospheric and aquatic ecosystem SMP exposure by 2050, because future plastics mobilization is controlled by releases from the large terrestrial discarded plastics reservoir (3500 Tg). Zero-release from 2025 onwards illustrates recovery of P and LMP reservoirs on centennial time scales, while SMP continue to cycle in air, soil, and surface ocean for millennia. Limiting dramatic future dispersal of plastics requires, in addition to reducing use and waste, remediation of the large terrestrial legacy plastics pool.
Training Hematologists/Oncologists for the Academic-Community Hybrid: Creating a Fellowship Framework for the Future
Authors: Roberts Daniel A. , Faig Jennifer , Bodio-Downey Kelly , Shpilsky Jason , Leahy Kathleen , Wischhusen Jonathan , Giordano Sara , Acharya Utkarsh , Drews Reed , Dougherty David , Lathan Christopher , Rangachari Deepa
Published: December 2022

PURPOSE:

Conventional hematology/oncology fellowship training is designed to foster careers in academic practice through intensive exposure to clinical and laboratory research. Even so, a notable proportion of graduating fellows opt to pursue a clinically focused career outside the realm of academic medicine. Given the corresponding shortage of oncologists in nonurban and rural settings, improving the representation of hematologists/oncologists in the community setting is a national priority.

METHODS:

We reviewed current national challenges and changing models of cancer care delivery in the context of the traditional academic training model along with trends in practice patterns for recent hematology/oncology graduates. We defined the Academic-Community hybrid (ACH) and how it supports the evolution in contemporary models of cancer care. We then drew on the authors’ experiences to formulate an innovative goal-concordant training paradigm for fellows seeking careers in the ACH model.

RESULTS:

The ACH hematology/oncology fellowship training pathway emphasizes and optimizes professional development domains including clinical care, patient safety and quality improvement, business and operations, cancer care equity and community access, healthy policy and alignment with professional organizations, and medical education.

CONCLUSION:

This novel hematology/oncology training model provides a paradigm for optimizing preparedness for practice in an increasingly complex cancer care delivery environment while addressing workforce shortages and health disparities.
Religious Hatred and Byzantine Ideology before the Crusades
Authors: ROTMAN Youval
Published: December 2022

Religious hatred has a long and painful history. It was conceptualized, defined and employed in various ways and for various ends throughout history. The present article focuses on the religious hatred and the roles that it played in Byzantium. It proposes a comparative approach to analyze expressions of religious hatred in Byzantine texts. The article does not analyze religious hatred as the actual hatred that a Christian might feel for his Jewish neighbor because he is Jewish, or vice-versa, but the way it appears in texts as a literary and rhetorical construction. What could be termed “Byzantine typology of religious hatred” as it presented and constructed in different types of texts by different authors will reveal the construction of a Byzantine perspective to mark political enemies as religious adversaries and vice versa. The question is to what end. This article proposes to look more closely into the way religious hatred served as a tool in the construction of Byzantine public opinion, a means for the Byzantines to perceive their polity and themselves as righteous.
Does The Household Structure Create Child Labor? The Case in Indonesia
Authors: Kharisma Bayu , Wardhana Adhitya , Hasanah Alfiah , Remi Sutyastie S. , Nurhanifa Sabila
Published: December 2022

The existence of child labor is a complex phenomenon and is often considered a logical consequence, in a household, of the economic needs of poverty-stricken families. This is due to several factors such as the condition of the child himself, the family background, and the influences of parents, culture and environment. This paper aims to determine the effect of household structure on child labor by comparing households headed by divorced single mothers and nuclear households that include a mother and father in Indonesia. This study uses cross-sectional data from the 2014 Indonesia Family Life Survey (IFLS) with the instrumental variable (IV) method. The results showed that, for the nuclear households that include a mother and father, the probability of child labor decreased, or that when a divorced single mother heads the household, the likelihood of child labor increases, including in rural areas. The same thing happens when households headed by divorced single mothers tend to increase the likelihood of sons being sent into the labor market. Thus, household structure has a vital role in determining the decisions of parents to engage their children in paid employment
Logan Medallist 7. Appinite Complexes, Granitoid Batholiths and Crustal Growth: A Conceptual Model
Authors: Murphy J. Brendan , Collins William J. , Archibald Donnelly B.
Published: December 2022

Appinite bodies are a suite of plutonic rocks, ranging from ultramafic to felsic in composition, that are characterized by idiomorphic hornblende as the dominant mafic mineral in all lithologies and by spectacularly diverse textures, including planar and linear magmatic fabrics, mafic pegmatites and widespread evidence of mingling between coeval mafic and felsic compositions. These features suggest crystallization from anomalously water-rich magma which, according to limited isotopic studies, has both mantle and meteoric components. Appinite bodies typically occur as small (~2 km diameter) complexes emplaced along the periphery of granitoid plutons and commonly adjacent to major deep crustal faults, which they preferentially exploit during their ascent. Several studies emphasize the relationship between intrusion of appinite, granitoid plutonism and termination of subduction. However, recent geochronological data suggest a more long-lived genetic relationship between appinite and granitoid magma generation and subduction.Appinite may represent aliquots of hydrous basaltic magma derived from variably fractionated mafic underplates that were originally emplaced during protracted subduction adjacent to the Moho, triggering generation of voluminous granitoid magma by partial melting in the overlying MASH zone. Hydrous mafic magma from this underplate may have ascended, accumulated, and differentiated at mid-to-upper crustal levels (ca. 3–6 kbar, 15 km depth) and crystallized under water-saturated conditions. The granitoid magma was emplaced in pulses when transient stresses activated favourably oriented structures which became conduits for magma transport. The ascent of late mafic magma, however, is impeded by the rheological barriers created by the structurally overlying granitoid magma bodies. Magma that forms appinite complexes evaded those rheological barriers because it preferentially exploited the deep crustal faults that bounded the plutonic system. In this scenario, appinite complexes may be a direct connection to the mafic underplate and so its most mafic components may provide insights into processes that generate granitoid batholiths and, more generally, into crustal growth in arc systems.
State-Dependent Estimation of Delay Distributions in Fork-Join Networks
Authors: Carmeli Nitzan , Yom-Tov Galit B. , Boxma Onno J.
Published: December 2022

Problem definition: Delay announcements have become an essential tool in service system operations: They influence customer behavior and network efficiency. Most current delay announcement methods are designed for relatively simple environments with a single service station or stations in tandem. However, complex service systems, such as healthcare systems, often have fork-join (FJ) structures. Such systems usually suffer from long delays as a result of both resource scarcity and process synchronization, even when queues are fairly short. These systems may thus require more accurate delay estimation techniques than currently available. Methodology/results: We analyze a network comprising a single-server queue followed by a two-station FJ structure using a recursive construction of the Laplace–Stieltjes transform of the joint delay distribution, conditioning on customers’ movements in the network. Delay estimations are made at the time of arrival to the first station. Using data from an emergency department, we examine the accuracy and the robustness of the proposed approach, explore different model structures, and draw insights regarding the conditions under which the FJ structure should be explicitly modeled. We provide evidence that the proposed methodology is better than other commonly used queueing theory estimators such as last-to-enter-service (which is based on snapshot-principle arguments) and queue length, and we replicate previous results showing that the most accurate estimations are obtained when using our model result as a feature in state-of-the-art machine learning estimation methods. Managerial implications: Our results allow management to implement individual, real-time, state-dependent delay announcements in complex FJ networks. We also provide rules of thumb with which one could decide whether to use a model with an explicit FJ structure or to reduce it to a simpler model requiring less computational effort.

Funding: This work was supported by the Dutch Research Council (NWO) Gravitation Programme NETWORKS [Grant 024.002.003], the Israel Ministry of Science and Technology [Grant 880011], and the Israel Science Foundation [Grant 1955/15].

Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.1167 .
Coaxial dual-core dispersion compensation photonic crystal fiber with wavelength-tunable ultrahigh negative dispersion
Authors: Shao Wanting , Liang Huan , Ma Fuxiao , Shi Weihua
Published: December 2022

A coaxial dual-core wavelength-tunable dispersion compensation photonic crystal fiber (WT-DC-PCF) is designed in this paper. The tunable range of 1512–1587 nm with an ultrahigh negative dispersion of

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at 1550 nm has been obtained simultaneously by filling the temperature-sensitive material into the air holes of the WT-DC-PCF. The full width at half-maximum is up to 12.4 nm, and a low confinement loss is always maintained. In addition, the phase-matching wavelength is basically linear with the temperature, which can be accurately adjusted to 1550 nm. Therefore, the proposed WT-DC-PCF is able to be used in achieving complete dispersion compensation in communication systems.
Few-mode optical fiber with a simple double-layer core supporting the O + C + L band weakly coupled mode- division multiplexing transmission
Authors: Mo Shuqi , Zhu He , Liu Jie , Liu Junyi , Zhang Jingxing , Shen Lei , Wang Xin , Wang Dawei , Li Zhaohui , Yu Siyuan
Published: December 2022

A weakly-coupled few mode fiber (FMF) with a simple double-layer core is designed and fabricated that support five (seven) weakly coupled mode groups with average attenuation of 0.21 dB/km (0.39 dB/km) at the C + L (O) optical wavelength bands. Two data transmission experiments are demonstrated utilizing the fiber. A 2-km orbital angular momentum (OAM) mode-group multiplexing (MGM) experiment in the O band achieves error-free transmission for all five multiplexed mode groups without multiple multiple-input multiple-output (MIMO) processing. A 40-km OAM mode division multiplexing (MDM) experiment supporting 14 mode channels in the C + L bands achieves bit error rates (BER) of below 2.4 × 10−2 (20% soft-decision forward-error-correction threshold) for all channels, based on low-complexity 4 × 4 or 2 × 2 MIMO equalization. These demonstrations prove the capability of the fiber to support weakly coupled MDM/MGM transmission across O + C + L optical wavelength bands.
Real-time light-field generation based on the visual hull for the 3D light-field display with free-viewpoint texture mapping
Authors: Yang Zeyuan , Sang Xinzhu , Yan Binbin , Chen Duo , Wang Peng , Wan Huaming , Chen Shuo , Li Jingwen
Published: December 2022

Real-time dense view synthesis based on three-dimensional (3D) reconstruction of real scenes is still a challenge for 3D light-field display. It’s time-consuming to reconstruct an entire model, and then the target views are synthesized afterward based on volume rendering. To address this issue, Light-field Visual Hull (LVH) is presented with free-viewpoint texture mapping for 3D light-field display, which can directly produce synthetic images with the 3D reconstruction of real scenes in real-time based on forty free-viewpoint RGB cameras. An end-to-end subpixel calculation procedure of the synthetic image is demonstrated, which defines a rendering ray for each subpixel based on light-field image coding. In the ray propagation process, only the essential spatial point of the target model is located for the corresponding subpixel by projecting the frontmost point of the ray to all the free-viewpoints, and the color of each subpixel is identified in one pass. A dynamic free-viewpoint texture mapping method is proposed to solve the correct graphic texture considering the free-viewpoint cameras. To improve the efficiency, only the visible 3D position and texture that contributes to the synthetic image are calculated based on backward ray tracing rather than computing the entire 3D model and generating all elemental images. In addition, an incremental calibration method by dividing camera groups is proposed to satisfy the accuracy. Experimental results show the validity of our method. All the rendered views are analyzed for justifying the texture mapping method, and the PSNR is improved by an average of 11.88dB. Finally, LVH can achieve a natural and smooth viewing effect at 4K resolution and the frame rate of 25 ∼ 30fps with a large viewing angle.
Fourier-inspired neural module for real-time and high-fidelity computer-generated holography
Authors: Dong Zhenxing , Xu Chao , Ling Yuye , Li Yan , Su Yikai
Published: December 2022

Learning-based computer-generated holography (CGH) algorithms appear as novel alternatives to generate phase-only holograms. However, most existing learning-based approaches underperform their iterative peers regarding display quality. Here, we recognize that current convolutional neural networks have difficulty learning cross-domain tasks due to the limited receptive field. In order to overcome this limitation, we propose a Fourier-inspired neural module, which can be easily integrated into various CGH frameworks and significantly enhance the quality of reconstructed images. By explicitly leveraging Fourier transforms within the neural network architecture, the mesoscopic information within the phase-only hologram can be more handily extracted. Both simulation and experiment were performed to showcase its capability. By incorporating it into U-Net and HoloNet, the peak signal-to-noise ratio of reconstructed images is measured at 29.16 dB and 33.50 dB during the simulation, which is 4.97 dB and 1.52 dB higher than those by the baseline U-Net and HoloNet, respectively. Similar trends are observed in the experimental results. We also experimentally demonstrated that U-Net and HoloNet with the proposed module can generate a monochromatic 1080p hologram in 0.015 s and 0.020 s, respectively.
Extending laser wavelengths to 1630 nm in centimeter-scale Er-phosphate fiber
Authors: Sun Yan , Yang Qiubai , Wang Yafei , Wang Fan , Jiang Xiaoqi , Wang Xin , Hu Lili , Yu Chunlei , Liao Meisong , Chen Shubin
Published: December 2022

The spectral bandwidth of Er-doped fibers limits their lasing wavelength at longer wave band. Here, to the best of our knowledge, we report a broad emission band (1420‒1680 nm) of Er3+ and demonstrate for the first time an Er-phosphate fiber, which supports laser oscillation at the extended wavelengths of 1627 nm and 1630 nm, with the output powers and slope efficiencies of 44 mW/12.5% and 16.5 mW/5.6%, respectively, pumped at 1480 nm. To the best of our knowledge, these are the highest output powers and slope efficiencies at 1627 nm and 1630 nm from an Er3+-doped all-fiber configuration.
Injection-locked highly Yb3+-doped uncoupled-61-core phosphate fiber laser
Authors: Li Lizhu , Zhu Xiushan , Wang Junfeng , Zong Jie , Li Maohe , Meyer Jason , Chavez-Pirson Arturo , Akbulut Mehmetcan , Norwood Robert A. , Peyghambarian Nasser
Published: December 2022

Uncoupled multicore fibers are promising platforms for advanced optical communications, optical computing, and novel laser systems. In this paper, an injection-locked highly ytterbium (Yb3+)-doped uncoupled-61-core phosphate fiber laser at 1030 nm is reported. The 61-core fiber with a core-to-core pitch of 20 μm was fabricated with the stack-and-draw technique. Each core doped with 6-wt.% Yb3+ ions has a diameter of 3 μm and numerical aperture of 0.2. Linearly polarized single-frequency output of 9.1 W was obtained from the injection-locked cavity with a 10-cm-long gain fiber at a pump power of 23.6 W. The injection locking of all 61 cores was confirmed by inspecting the longitudinal modes of the individual lasers with a scanning Fabry–Perot interferometer. The performance of the injection-locked 61-core fiber laser was characterized and compared to that of the free-running operation in terms of optical spectrum, near- and far-field intensity profiles, and relative intensity noise.
Environmental and ecological controls of the spatial distribution of microbial populations in aggregates
Authors: Martinez-Rabert Eloi , van Amstel Chiel , Smith Cindy , Sloan William T. , Gonzalez-Cabaleiro Rebeca
Published: December 2022

In microbial communities, the ecological interactions between species of different populations are responsible for the spatial distributions observed in aggregates (granules, biofilms or flocs). To explore the underlying mechanisms that control these processes, we have developed a mathematical modelling framework able to describe, label and quantify defined spatial structures that arise from microbial and environmental interactions in communities. An artificial system of three populations collaborating or competing in an aggregate is simulated using individual-based modelling under different environmental conditions. In this study, neutralism, competition, commensalism and concurrence of commensalism and competition have been considered. We were able to identify interspecific segregation of communities that appears in competitive environments (columned stratification), and a layered distribution of populations that emerges in commensal (layered stratification). When different ecological interactions were considered in the same aggregate, the resultant spatial distribution was identified as the one controlled by the most limiting substrate. A theoretical modulus was defined, with which we were able to quantify the effect of environmental conditions and ecological interactions to predict the most probable spatial distribution. The specific microbial patterns observed in our results allowed us to identify the optimal spatial organizations for bacteria to thrive when building a microbial community and how this permitted co-existence of populations at different growth rates. Our model reveals that although ecological relationships between different species dictate the distribution of bacteria, the environment controls the final spatial distribution of the community.
Population heterogeneity in Plasmodium vivax relapse risk
Authors: Stadler Eva , Cromer Deborah , Mehra Somya , Adekunle Adeshina I. , Flegg Jennifer A. , Anstey Nicholas M. , Watson James A. , Chu Cindy S. , Mueller Ivo , Robinson Leanne J. , Schlub Timothy E. , Davenport Miles P. , Khoury David S.
Published: December 2022

A key characteristic of Plasmodium vivax parasites is their ability to adopt a latent liver-stage form called hypnozoites, able to cause relapse of infection months or years after a primary infection. Relapses of infection through hypnozoite activation are a major contributor to blood-stage infections in P vivax endemic regions and are thought to be influenced by factors such as febrile infections which may cause temporary changes in hypnozoite activation leading to ‘temporal heterogeneity’ in reactivation risk. In addition, immunity and variation in exposure to infection may be longer-term characteristics of individuals that lead to ‘population heterogeneity’ in hypnozoite activation. We analyze data on risk of P vivax in two previously published data sets from Papua New Guinea and the Thailand-Myanmar border region. Modeling different mechanisms of reactivation risk, we find strong evidence for population heterogeneity, with 30% of patients having almost 70% of all P vivax infections. Model fitting and data analysis indicates that individual variation in relapse risk is a primary source of heterogeneity of P vivax risk of recurrences.

Trial Registration: ClinicalTrials.gov NCT01640574, NCT01074905, NCT02143934.
Utility of carotid ultrasound on prediction of 1-year mortality in emergency department patients with neurological deficits: A 10-year population-based cohort study
Authors: Chen Chi-Hsin , Sung Chih-Wei , Jeng Jiann-Shing , Fan Cheng-Yi , Chang Jia-How , Chen Jiun-Wei , Tang Sung-Chun , Huang Edward Pei-Chuan
Published: December 2022

Background

This study aimed to investigate the association between the carotid ultrasound results and 1-yr mortality of patients with neurological deficits in the emergency department (ED).

Methods

This study included patients with neurological symptoms who presented to the ED between January 1, 2009 and December 31, 2018, and underwent sonographic imaging of the bilateral carotid bulb, common carotid artery (CCA), internal carotid artery (ICA), and external carotid arteries. A stenosis degree of >50% was defined as significant carotid stenosis. Carotid plaque score (CPS) was calculated by adding the score of stenosis severity of all segments. The association between carotid ultrasound results and 1-yr mortality was investigated using the Cox regression model.

Results

The analysis included 7,961 patients (median age: 69 yr; men: 58.7%). Among them, 247 (3.1%) passed away from cardiovascular (CV)-related causes, and 746 (9.4%) died within a year. The mortality group presented with more significant carotid stenosis of the carotid bulb, CCA, or ICA and had a higher median CPS. A higher CPS was associated with a greater 1-yr all-cause mortality (adjusted hazard ratio [aHR] = 1.08; 95% confidence interval [CI] = 1.03–1.13; p = 0.001; log-rank p < 0.001) and CV-related mortality (aHR = 1.13; 95% CI = 1.04–1.22; p = 0.002, log-rank p < 0.001). Significant stenosis of either carotid artery segment did not result in a higher risk of 1-yr mortality.

Conclusions

We comprehensively investigated the utility of carotid ultrasound parameters on predicting mortality in this 10-yr population-based cohort, which included over 7,000 patients with acute neurological deficits presented to the ED. The result showed that CPS could be used as risk stratification tools for 1-yr all-cause and CV mortality.
Analysis of cattle movement networks in Paraguay: Implications for the spread and control of infectious diseases
Authors: Avalos Amaias , Durand Benoit , Naranjo José , Maldonado Victor , Canini Laetitia , Zanella Gina
Published: December 2022

Beef exports represent a substantial part of Paraguay’s agricultural sector. Cattle movements involve a high risk due to the possible spread of bovine diseases that can have a significant impact on the country’s economy. We analyzed cattle movements from 2014 to 2018 using the networks analysis methodology at the holding and district levels at different temporal scales. We built two types of networks to identify network characteristics that may contribute to the spread of two diseases with different epidemiological characteristics: i) a network including all cattle movements to consider the transmission of a disease of rapid spread like foot and mouth disease, and ii) a network including only cow movements to account for bovine brucellosis, a disease of slow spread that occurs mainly in adult females. Network indicators did not vary substantially among the cattle and cow only networks. The holdings/districts included in the largest strongly connected components were distributed throughout the country. Percolation analysis performed at the holding level showed that a large number of holdings should be removed to make the largest strongly connected component disappear. Higher values of the centrality indicators were found for markets than for farms, indicating that they may play an important role in the spread of an infectious disease. At the holding level (but not at the district level), the networks exhibited characteristics of small-world networks. This property may facilitate the spread of foot and mouth disease in case of re-emergence, or of bovine brucellosis in the country through cattle movements. They should be taken into account when implementing surveillance or control measures for these diseases.
Combination effect of cold atmospheric plasma with green synthesized zero-valent iron nanoparticles in the treatment of melanoma cancer model
Authors: Yazdani Zahra , Biparva Pourya , Rafiei Alireza , Kardan Mostafa , Hadavi Seyedehniaz
Published: December 2022

Green synthesized zero-valent iron nanoparticles (nZVI) have high potential in cancer therapy. Cold atmospheric plasma (CAP) is also an emerging biomedical technique that has great potential to cure cancer. Therefore, the combined effect of CAP and nZVI might be promising in treatment of cancer. In this study, we evaluated the combined effect of CAP and nZVI on the metabolic activity of the surviving cells and induction of apoptosis in malignant melanoma in comparison with normal cells. Therefore, the effect of various time exposure of CAP radiation, different doses of nZVI, and the combined effect of CAP and nZVI were evaluated on the viability of malignant melanoma cells (B16-F10) and normal fibroblast cells (L929) at 24 h after treatment using MTT assay. Then, the effect of appropriate doses of each treatment on apoptosis was evaluated by fluorescence microscopy and flow cytometry with Annexin/PI staining. In addition, the expression of BAX, BCL2 and Caspase 3 (CASP3) was also assayed. The results showed although the combined effect of CAP and nZVI significantly showed cytotoxic effects and apoptotic activity on cancer cells, this treatment had no more effective compared to CAP or nZVI alone. In addition, evaluation of gene expression showed that combination therapy didn’t improve expression of apoptotic genes in comparison with CAP or nZVI. In conclusion, combined treatment of CAP and nZVI does not seem to be able to improve the effect of monotherapy of CAP or nZVI. It may be due to the resistance of cancer cells to high ROS uptake or the accumulation of saturated ROS in cells, which prevents the intensification of apoptosis.
Identification of anti-SARS-CoV-2 agents based on flavor/fragrance compositions that inhibit the interaction between the virus receptor binding domain and human angiotensin converting enzyme 2
Authors: Nishimura Yasumitsu , Nomiyama Kenta , Okamoto Shuichiro , Igarashi Mika , Yorifuji Yusuke , Sato Yukino , Kamezaki Ayasa , Morihara Aya , Kuribayashi Futoshi , Yamauchi Akira
Published: December 2022

Coronavirus disease 2019 (COVID-19) pandemic poses a threat to human beings and numerous cases of infection as well as millions of victims have been reported. The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein receptor binding domain (RBD) to human angiotensin converting enzyme 2 (hACE2) is known to promote the engulfment of the virus by host cells. Employment of flavor/fragrance compositions to prevent SARS-CoV-2 infection by inhibiting the binding of viral RBD (vRBD) to hACE2 might serve as a favorable, simple, and easy method for inexpensively preventing COVID-19, as flavor/fragrance compositions are known to directly interact with the mucosa in the respiratory and digestive systems and have a long history of use and safety assessment. Herein we report the results of screening of flavor/fragrance compositions that inhibit the binding of vRBD to hACE2. We found that the inhibitory effect was observed with not only the conventional vRBD, but also variant vRBDs, such as L452R, E484K, and N501Y single-residue variants, and the K417N+E484K+N501Y triple-residue variant. Most of the examined flavor/fragrance compositions are not known to have anti-viral effects. Cinnamyl alcohol and Helional inhibited the binding of vRBD to VeroE6 cells, a monkey kidney cell line expressing ACE2. We termed the composition with inhibitory effect on vRBD-hACE2 binding as “the molecularly targeted flavor/fragrance compositions”. COVID-19 development could be prevented by using these compositions with reasonable administration methods such as inhalation, oral administration, and epidermal application.