bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling for the Relationship between Monetary Policy and GDP in the USA Using Statistical Methods
Authors: Amaral Andre , Dyhoum Taysir E. , Abdou Hussein A. , Aljohani Hassan M.
Published: November 2022

The Federal Reserve has played an arguably important role in financial crises in the United States since its creation in 1913 through monetary policy tools. Thus, this paper aims to analyze the impact of monetary policy on the United States’ economic growth in the short and long run, measured by Gross Domestic Product (GDP). The Vector Autoregressive (VAR) method explores the relationship among the variables, and the Granger causality test assesses the predictability of the variables. Moreover, the Impulse Response Function (IRF) examines the behavior of one variable after a change in another, utilizing the time-series dataset from the first quarter of 1959 to the second quarter of 2022. This work demonstrates that expansionary monetary policy does have a positive impact on economic growth in the short term though it does not last long. However, in the long term, inflation, measured by the Consumer Price Index (CPI), is affected by expansionary monetary policy. Therefore, if the Federal Reserve wants to cease the expansionary monetary policy in the short run, this should be done appropriately, with the fiscal surplus, to preserve its credibility and trust in the US dollar as a global store of value asset. Also, the paper’s findings suggest that continuous expansion of the Money Supply will lead to a long-term inflationary problem. The purpose of this research is to bring the spotlight to the side effects of expansionary monetary policy on the US economy, but also allow other researchers to test this model in different economies with different dynamics.
A Weakly Nonlinear Dynamic Problem for a Model of the Thermoelastic Medium Absorbing a Part of the Acoustic Spectrum
Authors: Babenkov Mikhail , Podolskaya Ekaterina
Published: November 2022

We consider a dynamic problem with a short laser impact on a semi-opaque insulated layer with free borders, accounting for the selective absorption of the acoustic spectrum regions by the media. The behavior of the material is modeled by the extended coupled thermoelasticity formulated in the previous work of the series. Following the experimental results, we introduce a weakly nonlinear correction to the thermal expansion coefficient. Thus, we aim to level out the inability of classical thermoelasticity (CTE) to correctly describe the deformation processes in a solid under a high-frequency impact, yet staying within the framework of linear models. The parameters of the system of novel equations can be tuned to fit the experimentally measured data, i.e., the frequency-dependent attenuation coefficient. The series solutions of the extended thermoelasticity problem are compared with those obtained within CTE. In contrast to CTE and in accordance with experiments, the model allows for the simultaneous existence of positive and negative extrema for stress over time.
Progressive Fracture Behavior and Acoustic Emission Release of CJBs Affected by Joint Distance Ratio
Authors: Wang Yongyi , Gong Bin , Zhang Yongjun , Yang Xiaoyu , Tang Chun’an
Published: November 2022

The progressive collapse behavior and energy release of columnar jointed basalts (CJBs) can be greatly influenced by different joint distance ratios. By adopting the digital image correlation, a series of heterogeneous CJB models are established. The continuous fracture process and acoustic emissions (AEs) are captured numerically under varying lateral pressures. The load curves under different joint distance ratios and model boundaries are analyzed. Meanwhile, the strength, deformation modulus and AE rule are discussed. The data indicate that under plane strain, the troughs of compression strength appear at the column dip angle β = 30°, 150°, 210° or 330°; the equivalent deformation modulus changes in an elliptical way with β increasing; the compression strength and equivalent deformation modulus are higher than the case between plane stress and plane strain under different joint distance ratios. When β = 30°, the accumulation of AE energy corresponding to the stress peak under plane strain are higher than the case between plane stress and plane strain but becomes lower when β increases to 60°, which implies the critical transformation of the AE energy-related failure precursor affected by column dip angle. These achievements will contribute to the design, construction and support of slopes and tunnels encountering CJBs.
Framework for Classroom Student Grading with Open-Ended Questions: A Text-Mining Approach
Authors: Vairinhos Valter Martins , Pereira Luís Agonia , Matos Florinda , Nunes Helena , Patino Carmen , Galindo-Villardón Purificación
Published: November 2022

The purpose of this paper is to present a framework based on text-mining techniques to support teachers in their tasks of grading texts, compositions, or essays, which form the answers to open-ended questions (OEQ). The approach assumes that OEQ must be used as a learning and evaluation instrument with increasing frequency. Given the time-consuming grading process for those questions, their large-scale use is only possible when computational tools can help the teacher. This work assumes that the grading decision is entirely a teacher’s task responsibility, not the result of an automatic grading process. In this context, the teacher is the author of questions to be included in the tests, administration and results assessment, the entire cycle for this process being noticeably short: a few days at most. An attempt is made to address this problem. The method is entirely exploratory, descriptive and data-driven, the only data assumed as inputs being the texts of essays and compositions created by the students when answering OEQ for a single test on a specific occasion. Typically, the process involves exceedingly small data volumes measured by the power of current home computers, but big data when compared with human capabilities. The general idea is to use software to extract useful features from texts, perform lengthy and complex statistical analyses and present the results to the teacher, who, it is believed, will combine this information with his or her knowledge and experience to make decisions on mark allocation. A generic path model is formulated to represent that specific context and the kind of decisions and tasks a teacher should perform, the estimated results being synthesised using graphic displays. The method is illustrated by analysing three corpora of 126 texts originating in three different real learning contexts, time periods, educational levels and disciplines.
Pneumothorax, an Uncommon but Devastating Complication Following Shoulder Arthroscopy: Case Reports
Authors: Sun Wei-Chien , Kuo Liang-Tseng , Yu Pei-An , Yang Cheng-Pang , Sheu Huan , Tang Hao-Che , Chan Yi-Sheng , Chen Alvin Chao-Yu , Hsu Kuo-Yao , Weng Chun-Jui , Cheng You-Hung , Chiu Chih-Hao
Published: November 2022

Shoulder arthroscopy is a mature and widely used treatment to deal with various shoulder disorders. It enables faster recovery and decreases postoperative complications. However, some complications related to shoulder arthroscopy cannot be neglected because they could be life threatening. We presented three cases of various clinical manifestations of pneumothorax after shoulder arthroscopy. The first case was a 65-year-old female who underwent arthroscopic rotator cuff repair under general anesthesia and interscalene nerve block in the beach-chair position. The second case was a 58-year-old male undergoing arthroscopic rotator cuff repair and reduction in glenoid fracture under general anesthesia in the lateral decubitus position. The third case was a 62-year-old man receiving arthroscopic rotator cuff repair under general anesthesia in the lateral decubitus position. Each case’s operation time was 90, 240, and 270 min. The pressure of the irrigation pumping system was 30, 50, and 70 mmHg, respectively. The second and third cases did not undergo interscalene nerve block. Although the incidence of pneumothorax following shoulder surgery and interscalene nerve block was only 0.2%, it is one of the most life-threatening complications following shoulder arthroscopy. In these cases, multifactorial factors, including patient positioning, interscalene nerve block, long surgical time, size of rotator cuff tears, and the pressure of the irrigation and suction system, can be attributed to the occurrence of pneumothorax. It is crucial to fully comprehend the diagnosis and management of pneumothorax to reduce the risk for patients receiving shoulder arthroscopy.
Increased Expression of Circulating Stress Markers, Inflammatory Cytokines and Decreased Antioxidant Level in Diabetic Nephropathy
Authors: Mansoor Ghazal , Tahir Muhammad , Maqbool Tahir , Abbasi Sana Qanber , Hadi Faheem , Shakoori Tania Ahmad , Akhtar Shabana , Rafiq Muhammad , Ashraf Muhammad , Ullah Inam
Published: November 2022

Background and Objectives: The main objective of the present study was to determine the role of oxidative markers (glutathione (GSH), advanced oxidation protein products (AOPP), advanced glycation end products (AGEs), and malondialdehyde (MDA)) and inflammatory biomarkers (interleukin-6 IL-6, tumor necrosis factor α (TNF-α), myeloperoxide (MPO)) in the development of diabetic nephropathy along with routinely used biochemical parameters. Materials and Method: This was a case control study. All the selected patients were screened and enrolled by convenient non-probability sampling technique at the Jinnah hospital in Lahore. Informed consent was obtained before enrollment of the study subjects. A total of 450 patients enrolled in the study, and they were divided into three groups, 150 subjects with type 2 diabetes and 150 diagnosed diabetic nephropathy (DN) vs. 150 healthy individuals as a control group. Five mL of venous blood sample was taken from the antecubital vein of each participant. Statistical analysis was performed by SPSS. The results of all variables were evaluated by using one way ANOVA. Results: The mean value of biochemical parameters (WBCs, platelets, prothrombin time, HbA1c, glucose, urinary albumin-to creatinine ratio (UACR), triglycerides, LDL, HDL, serum creatinine, urinary albumin (creatinine)) were increased and Hb (g/dL), red blood cells (RBCs), hematocrit (Hct), free serum insulin levels, and estimated glomerular filtration rate (eGFR) were decreased in the nephropathy group compared to the control and type 2 diabetes groups. The mean values of MDA, AGE, and AOPPs in type 2 diabetes and diabetic nephropathy were significantly increased compared to the control group. GSH level was decreased in type 2 diabetics and DN patients as compared to the control group. In addition, IL-6, TNFα, and MPO levels were also increased in case of diabetes nephropathy compared to controls. Conclusions: ROS mediated injuries can be prevented by the restoration of an antioxidant defense system, through the administration of antioxidant agents. Moreover, increased levels of inflammatory mediators are responsible for enhancing inflammation in patients with diabetic nephropathy.
Efficacy of Systemic Amoxicillin–Metronidazole in Periodontitis Patients with Diabetes Mellitus: A Systematic Review of Randomized Clinical Trials
Authors: Mugri Maryam Hassan
Published: November 2022

Systemic amoxicillin–metronidazole was proven to be effective in managing periodontitis in systemically healthy patients. It was demonstrated that systemic antibiotic therapy can effectively improve clinical periodontal parameters and reduce periodontopathogenic organisms in the subgingival biofilm. However, the evidence for prescribing this drug combination to patients with diabetes remains insufficient. This systematic review was designed to evaluate the effectiveness of a systemic amoxicillin–metronidazole combination as an adjunct to nonsurgical periodontal therapy in patients with diabetes presenting with chronic periodontitis. The PubMed, Scopus, and Web of Science databases were electronically searched for randomized clinical trials in January 2022. Randomized clinical trials evaluating systemic amoxicillin–metronidazole therapy as an adjunct to nonsurgical periodontal therapy in patients with type 2 diabetes presenting with periodontitis were selected for screening. The qualities of the studies were assessed using the Cochrane Collaboration’s Tool for Assessing Risk of Bias Version 2.0 (ROB-2), and a GRADE assessment was applied to estimate the overall certainty of the evidence. Using predefined eligibility criteria, four clinical trials examining 209 patients were selected from the 611 articles identified in the search. Two studies reported a better reduction in clinical parameters when SRP was combined with systemic amoxicillin–metronidazole. Systemic amoxicillin–metronidazole was found to be as effective as clindamycin. Surgical therapy with systemic amoxicillin–metronidazole was more effective than nonsurgical therapy with systemic amoxicillin–metronidazole, even though both resulted in reduced clinical parameters. Combined amoxicillin–metronidazole was observed to reduce periodontal probing depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP) compared to no treatment or NSPT alone. However, the effect was not greater when compared to NSPT with clindamycin or surgical therapy with amoxicillin–metronidazole. Further randomized trials are required before clinical guidelines can be established for the use of systemic amoxicillin–metronidazole. Future randomized controlled clinical trials with long-term follow-ups are required to assess the efficacy of systemic antibiotic therapy in managing periodontitis in patients with diabetes.
Assessment of the Effect of Residual Stresses Arising in the HAZ of Welds on the Fatigue Life of S700MC Steel
Authors: Bukovská Šárka , Moravec Jaromír , Solfronk Pavel , Pekárek Milan
Published: November 2022

Fine-grained steels, which belong to the HSLA (High-Strength Low-Alloy) group of steels, are increasingly used for parts of statically and dynamically loaded constructions. Due to the thermal effect of welding, combined with the inherent stiffness and clamping stiffness of the part, residual stresses are generated in the HAZ (heat-affected zone) which affect the fatigue life of the sub-weld and the entire construction. In this article, a specific temperature cycle measured during welding is used, which, together with a defined clamping stiffness, produces residual stresses of a defined shape and value in the sample. Subsequently, the effect of these stresses on the fatigue life on the change of the S–N curve compared to the annealed material, is assessed. Temperature cycles were applied using a Gleeble 3500 and the residual stresses were analyzed by X-ray diffraction (XRD). It was found that the effect of residual stresses decreased the fatigue strength by 33% compared to the annealed material. It was further found that by using annealing to reduce the residual stresses, it is possible to restore the fatigue life of S700MC steel to the original value of the base material.
Metabolic Dysfunction-Associated Fatty Liver Disease in the National Health and Nutrition Examination Survey 2017–2020: Epidemiology, Clinical Correlates, and the Role of Diagnostic Scores
Authors: Theofilis Panagiotis , Vordoni Aikaterini , Kalaitzidis Rigas G.
Published: November 2022

The recent establishment of metabolic dysfunction-associated fatty liver disease (MAFLD) has led to a reevaluation of its epidemiology, diagnosis, and clinical implications. In this study, we aimed to evaluate MAFLD’s epidemiology and its association with other pathologic states and biomarkers, as well as to assess the prevalence of the different fibrosis stages in the MAFLD population, together with the importance of diagnostic scores in the preliminary determination of significant fibrosis. After analyzing the National Health and Nutrition Examination Survey (NHANES) 2017–2020, we found a high prevalence of MAFLD, at 58.6% of the studied population. MAFLD was accompanied by numerous comorbidities, which were increasingly common in individuals with higher grades of liver fibrosis. Fatty liver index emerged as a reliable indicator of MAFLD, as well as significant fibrosis. The estimation of fatty liver index could be a reasonable addition to the evaluation of patients with metabolic risk factors and could lead a diagnosis in the absence of liver elastography or biopsy. Further studies are needed to enhance our knowledge regarding its prognosis, as well as the role of novel therapies in its prevention or regression.
Quantitative Analyses and Validation of Phospholipids and Sphingolipids in Ischemic Rat Brains
Authors: Huang Chiung-Yin , Tsai Ping-Ju , Wu Hsuan-Wen , Chen I-Ting , Wang Hay-Yan J.
Published: November 2022

Prior MALDI mass spectrometry imaging (MALDI-MSI) studies reported significant changes in phosphatidylcholines (PCs), lysophosphatidylcholines (LPCs), and sphingomyelins (SMs) in ischemic rat brains yet overlooked the information on other classes of PLs and SLs and provided very little or no validation on the detected lipid markers. Relative quantitation of four classes of PLs and two classes of SLs in the ischemic and normal temporal cortex (TCX), parietal cortex (PCX), and striatum (ST) of rats was performed with hydrophilic interaction chromatography (HILIC)–tandem mass spectrometry (MS/MS) analyses, and the marker lipid species was identified by multivariate data analysis and validated with additional tissue cohorts. The acquired lipid information was sufficient in differentiating individual anatomical regions under different pathological states, identifying region-specific ischemic brain lipid markers and revealing additional PL and SL markers not reported previously. Validation of orthogonal partial least square discriminating analysis (OPLS-DA) identified ischemic brain lipid markers yielded much higher classification accuracy, precision, specificity, sensitivity, and lower false positive and false negative rates than those from the volcano plot analyses using conventional statistical significance and a fold change of two as the cutoff and provided a wider prospective to ischemia-associated brain lipid changes.
Bandwidth Enhancement and Generation of CP of Yagi-Uda-Shape Feed on a Rectangular DRA for 5G Applications
Authors: Bari Inam , Iqbal Javed , Ali Haider , Rauf Abdul , Bilal Muhammad , Jan Naveed , Illahi Usman , Arif Muhammad , Khan Muhammad Amir , Ghoniem Rania M.
Published: November 2022

A wideband circularly polarized rectangular dielectric resonator antenna (DRA) fed by a single feeding mechanism has been studied theoretically and experimentally. The purpose of the study is to determine how adding a parasitic strip next to the flat surface metallic feed would affect various far- and near-field antenna characteristics. Initially, the basic antenna design, i.e., the T-shape feed known as antenna A, produced a 4.81% impedance matching bandwidth (|S11| −10 dB). Due to the narrow and undesirable results of the initial antenna design, antenna-A was updated to the antenna-B design, i.e., Yagi-Uda. The antenna-B produced a decent result (7.89% S11) as compared to antenna-A but still needed the bandwidth widened, for this, a parasitic patch was introduced next to the Yagi-Uda antenna on the rectangular DRA at an optimized location to further improve the results. This arrangement produced circular polarization (CP) waves spanning a broad bandwidth of 28.21% (3.59–3.44 GHz) and a broad impedance |S11| bandwidth of around 29.74% (3.71–3.62 GHz). These findings show that, in addition to producing CP, parasite patches also cause the return loss to rise by a factor of almost three times when compared to results obtained with the Yagi-Uda-shape feed alone. Computer simulation technology was used for the simulation (CST-2017). The planned antenna geometry prototype was fabricated and measured. Performance indicators show that the suggested antenna is a good fit for 5G applications. The simulated outcomes and measurements match up reasonably.
Pathogenicity of Aeromonas veronii Causing Mass Mortality of Largemouth Bass (Micropterus salmoides) and Its Induced Host Immune Response
Authors: Zhu Xinhai , Qian Qieqi , Wu Congcong , Zhu Yujie , Gao Xiaojian , Jiang Qun , Wang Jun , Liu Guoxing , Zhang Xiaojun
Published: November 2022

Aeromonas veronii is as an important opportunist pathogen of many aquatic animals, which is wildly distributed in various aquatic environments. In this study, a dominant bacterium GJL1 isolated from diseased M. salmoides was identified as A. veronii according to the morphological, physiological, and biochemical characteristics, as well as molecular identification. Detection of the virulence genes showed the isolate GJL1 carried outer membrane protein A (ompA), flagellin (flgA, flgM, flgN), aerolysin (aer), cytolytic enterotoxin (act), DNases (exu), and hemolysin (hly), and the isolate GJL1 also produced caseinase, lipase, gelatinase, and hemolysin. The virulence of strain GJL1 was confirmed by experimental infection; the median lethal dosage (LD50) of the GJL1 for largemouth bass was 3.6 × 105 CFU/mL, and histopathological analysis revealed that the isolate could cause obvious inflammatory responses in M. salmoides. Additionally, the immune-related gene expression in M. salmoides was evaluated, and the results showed that IgM, HIF-1α, Hep-1, IL-15, TGF-β1, and Cas-3 were significantly upregulated after A. veronii infection. Our results indicated that A. veronii was an etiological agent causing the mass mortality of M. salmoides, which contributes to understanding the immune response of M. salmoides against A. veronii infection.
Characterization of Sideritis clandestina subsp. peloponnesiaca Polar Glycosides and Phytochemical Comparison to Other Mountain Tea Populations
Authors: Dimaki Virginia D. , Zeliou Konstantina , Nakka Fotini , Stavreli Michaela , Bakratsas Ioannis , Papaioannou Ligeri , Iatrou Gregoris , Lamari Fotini N.
Published: November 2022

Sideritis clandestina (Bory & Chaub.) Hayek subsp. peloponnesiaca (Boiss. & Heldr.) Baden (SCP) is endemic to the mountains of the Northern Peloponnese (Greece). This and other Sideritis taxa, collectively known as mountain tea, are widely ingested as beverages for refreshment or medicinal purposes. We describe a methodology for the characterization of SCP. Four iridoid glycosides (monomelittoside, melittoside, ajugoside, and 7-O-acetyl-8-epiloganic acid), two phenolic acid glycosides (vanillic and salicylic acid glycosides), and three caffeoyl ester glycosides (chlorogenic acid, verbascoside, and isoverbascoside) were isolated from SCP for the first time. We used ultrasound-assisted extraction of 3 g of plant material to produce petroleum ether and aqueous extracts, which we then analyzed using GC/MS and LC/MS. This was applied to eight samples from four different taxa. In total, 70 volatile and 27 polar metabolites were determined. The S. clandestina samples had a lower phenolic content and weaker antioxidant properties than S. raeseri and S. scardica. However, S. clandestina ssp. clandestina seemed to be the most aromatic taxon, with almost double the number of volatiles as the others. Τhis study could contribute to authentication and chemotaxonomic studies of Sideritis taxa.
Quercetin’s Effects on Glutamate Cytotoxicity
Authors: Riche Kade , Lenard Natalie R.
Published: November 2022

The potentially therapeutic effects of the naturally abundant plant flavonoid quercetin have been extensively studied. An extensive body of literature suggests that quercetin’s powerful antioxidant effects may relate to its ability to treat disease. Glutamate excitotoxicity occurs when a neuron is overstimulated by the neurotransmitter glutamate and causes dysregulation of intracellular calcium concentrations. Quercetin has been shown to be preventative against many forms of neuronal cell death resulting from glutamate excitotoxicity, such as oncosis, intrinsic apoptosis, mitochondrial permeability transition, ferroptosis, phagoptosis, lysosomal cell death, parthanatos, and death by reactive oxygen species (ROS)/reactive nitrogen species (RNS) generation. The clinical importance for the attenuation of glutamate excitotoxicity arises from the need to deter the continuous formation of tissue infarction caused by various neurological diseases, such as ischemic stroke, seizures, neurodegenerative diseases, and trauma. This review aims to summarize what is known concerning glutamate physiology and glutamate excitotoxic pathophysiology and provide further insight into quercetin’s potential to hinder neuronal death caused by cell death pathways activated by glutamate excitotoxicity. Quercetin’s bioavailability may limit its use clinically, however. Thus, future research into ways to increase its bioavailability are warranted.
Recent Research and Application Prospect of Functional Oligosaccharides on Intestinal Disease Treatment
Authors: Xu Tong , Sun Ruijie , Zhang Yuchen , Zhang Chen , Wang Yujing , Wang Zhuo A. , Du Yuguang
Published: November 2022

The intestinal tract is an essential digestive organ of the human body, and damage to the intestinal barrier will lead to various diseases. Functional oligosaccharides are carbohydrates with a low degree of polymerization and exhibit beneficial effects on human intestinal health. Laboratory experiments and clinical studies indicate that functional oligosaccharides repair the damaged intestinal tract and maintain intestinal homeostasis by regulating intestinal barrier function, immune response, and intestinal microbial composition. Functional oligosaccharides treat intestinal disease such as inflammatory bowel disease (IBD) and colorectal cancer (CRC) and have excellent prospects for therapeutic application. Here, we present an overview of the recent research into the effects of functional oligosaccharides on intestinal health.
Effects of Blood Flow Restricted Exercise on Electromechanical Delay and Time to Peak Force after Task Failure: A Randomized Crossover Trial
Authors: Cerqueira Mikhail Santos , Lira Maria , da Silva Raiff Simplicio , Machado Marco , Pereira Rafael
Published: November 2022

Introduction: Electromechanical delay (ED) and time to peak force (TPF) could be used to investigate the central or peripheral sources of performance decline in fatiguing tasks. Exercise with partial blood flow restriction (BFR) has been shown to induce fatigue, but the repercussions of exercise with partial BFR on ED and TPF are unclear. The present study aimed to compare the ED and TPF after an intermittent isometric task until failure with BFR and free blood flow (FBF). Methods: In this crossover randomized clinical trial, 15 healthy and physically active men volunteered in this study. Volunteers performed two intermittent isometric handgrip exercise (IIHE) to failure (72 h apart), combined with either BFR or FBF. Maximum voluntary isometric force (MVIF) concomitant with the electromyographic activity of the wrist and finger flexor muscles were assessed before (PRE) and one minute after (POST) the task failure. Within (PRE vs. POST) and between comparisons (eFBF vs. eBFR) of peak force, time to peak force, rate of force development (RFDpeak) and ED were carried out. Results: No significant between-intervention differences were identified pre- or post-exercise. Peak force and RFDpeak reduced significantly after both blood flow conditions (p < 0.05), but without between-condition difference. TPF was statistically higher after exercise only in the FBF intervention (p < 0.05). None of the interventions induced a significant change in the ED after IIHE. Conclusion: ED and TPF were similar after BFR and FBF, indicating both conditions induce similar acute performance impairments after IIHE, which seems not to be caused by local (i.e., muscular) factors, but probably by central (i.e., neural) factors.
Capacitive Desalination and Disinfection of Water Using UiO-66 Metal–Organic Framework/Bamboo Carbon with Chitosan
Authors: Cao Cuihui , Wu Xiaofeng , Zheng Yuming , Zhang Lizhen , Chen Yunfa
Published: November 2022

The zirconium-based metal–organic framework (MOF) (UiO-66)/bamboo carbon (BC) composite with chitosan was prepared using hydrothermal and impregnation methods and used for capacitive desalination (CDI) and disinfection of water. The results showed that these composites had fast ion exchange and charge transfer properties. During the CDI process, these composites’ electrodes exhibited good cycle stability, electrosorption capacity (4.25 mg/g) and excellent bactericidal effect. These carbon-based composites electrodes’ bactericidal rate for Escherichia coli could reach 99.99% within 20 minutes; therefore, they had good performance and were a good choice for high-performance deionization applications.
Bioresource-Functionalized Quantum Dots for Energy Generation and Storage: Recent Advances and Feature Perspective
Authors: Mousavi Seyyed Mojtaba , Hashemi Seyyed Alireza , Yari Kalashgrani Masoomeh , Kurniawan Darwin , Gholami Ahmad , Chiang Wei-Hung
Published: November 2022

The exponential increase in global energy demand in daily life prompts us to search for a bioresource for energy production and storage. Therefore, in developing countries with large populations, there is a need for alternative energy resources to compensate for the energy deficit in an environmentally friendly way and to be independent in their energy demands. The objective of this review article is to compile and evaluate the progress in the development of quantum dots (QDs) for energy generation and storage. Therefore, this article discusses the energy scenario by presenting the basic concepts and advances of various solar cells, providing an overview of energy storage systems (supercapacitors and batteries), and highlighting the research progress to date and future opportunities. This exploratory study will examine the systematic and sequential advances in all three generations of solar cells, namely perovskite solar cells, dye-sensitized solar cells, Si cells, and thin-film solar cells. The discussion will focus on the development of novel QDs that are economical, efficient, and stable. In addition, the current status of high-performance devices for each technology will be discussed in detail. Finally, the prospects, opportunities for improvement, and future trends in the development of cost-effective and efficient QDs for solar cells and storage from biological resources will be highlighted.
Nanoparticles: The Plant Saviour under Abiotic Stresses
Authors: Khalid Muhammad Fasih , Iqbal Khan Rashid , Jawaid Muhammad Zaid , Shafqat Waqar , Hussain Sajjad , Ahmed Talaat , Rizwan Muhammad , Ercisli Sezai , Pop Oana Lelia , Alina Marc Romina
Published: November 2022

Climate change significantly affects plant growth and productivity by causing different biotic and abiotic stresses to plants. Among the different abiotic stresses, at the top of the list are salinity, drought, temperature extremes, heavy metals and nutrient imbalances, which contribute to large yield losses of crops in various parts of the world, thereby leading to food insecurity issues. In the quest to improve plants’ abiotic stress tolerance, many promising techniques are being investigated. These include the use of nanoparticles, which have been shown to have a positive effect on plant performance under stress conditions. Nanoparticles can be used to deliver nutrients to plants, overcome plant diseases and pathogens, and sense and monitor trace elements that are present in soil by absorbing their signals. A better understanding of the mechanisms of nanoparticles that assist plants to cope with abiotic stresses will help towards the development of more long-term strategies against these stresses. However, the intensity of the challenge also warrants more immediate approaches to mitigate these stresses and enhance crop production in the short term. Therefore, this review provides an update of the responses (physiological, biochemical and molecular) of plants affected by nanoparticles under abiotic stress, and potentially effective strategies to enhance production. Taking into consideration all aspects, this review is intended to help researchers from different fields, such as plant science and nanoscience, to better understand possible innovative approaches to deal with abiotic stresses in agriculture.
Iron: Not Just a Passive Bystander in AITD
Authors: Szklarz Michał , Gontarz-Nowak Katarzyna , Matuszewski Wojciech , Bandurska-Stankiewicz Elżbieta
Published: November 2022

Autoimmune thyroid disease (AITD) is the most prevalent autoimmune disease all over the world and the most frequent cause of hypothyroidism in areas of iodine sufficiency. The pathogenesis of AITD is multifactorial and depends on complex interactions between genetic and environmental factors, with epigenetics being the crucial link. Iron deficiency (ID) can reduce the activities of thyroid peroxidase and 5′-deiodinase, inhibit binding of triiodothyronine to its nuclear receptor, and cause slower utilization of T3 from the serum pool. Moreover, ID can disturb the functioning of the immune system, increasing the risk of autoimmune disorders. ID can be responsible for residual symptoms that may persist in patients with AITD, even if their thyrometabolic status has been controlled. The human lifestyle in the 21st century is inevitably associated with exposure to chemical compounds, pathogens, and stress, which implies an increased risk of autoimmune disorders and thyroid dysfunction. To summarize, in our paper we discuss how iron deficiency can impair the functions of the immune system, cause epigenetic changes in human DNA, and potentiate tissue damage by chemicals acting as thyroid disruptors.
Association between the Intake of Different Protein Sources and Obesity Coexisting with Low Handgrip Strength in Persons near Retirement Age
Authors: Eglseer Doris , Traxler Mariella , Bauer Silvia
Published: November 2022

Nutrition is important for preventing and treating sarcopenic obesity/SO, proteins play a fundamental role. This study aimed at (1) identifying the association between different protein sources, other factors, and obesity coexisting with low handgrip strength and (2) evaluating differences in protein intake between persons with coexistence of obesity with low handgrip strength, obesity alone, low handgrip strength alone and persons neither obese nor having low handgrip strength. This study is a secondary data analysis of SHARE-data among 5362 persons near retirement age. We used descriptive statistics, statistical tests and univariate and multiple logistic regression analyses. Prevalence of obesity coexisting with low handgrip strength was 4.8%. Participants with low handgrip strength had the significantly lowest intake of all protein groups, followed by participants with obesity and low handgrip strength (p < 0.001). Daily intake of meat/fish (0.56, CI 0.40–0.79), age (1.07, CI 1.03–1.11), two or more chronic diseases (2.22, CI 1.69–2.93), one or more limitations concerning instrumental activities of daily living (2.23, CI 1.60–3.11), and moderate activity more than once a week (0.44, CI 0.33–0.57) were significantly related factors regarding obesity coexisting with low handgrip strength. Findings suggest that a daily intake of meat/fish is associated with lower odds of suffering from obesity with low handgrip strength in retirement-aged persons. Further studies are needed for specific recommendations regarding different protein sources for obese persons with low muscle mass and/or strength.
The Effect of Healthy Lifestyle Strategies on the Management of Insulin Resistance in Children and Adolescents with Obesity: A Narrative Review
Authors: Calcaterra Valeria , Verduci Elvira , Vandoni Matteo , Rossi Virginia , Fiore Giulia , Massini Giulia , Berardo Clarissa , Gatti Alessandro , Baldassarre Paola , Bianchi Alice , Cordaro Erika , Cavallo Caterina , Cereda Cristina , Bosetti Alessandra , Zuccotti Gianvincenzo
Published: November 2022

Childhood obesity is characterized by an increased risk of several metabolic derangements including insulin resistance (IR). The strongest recommendations to prevent obesity and related complications are a balanced and adequate diet and practicing physical activity from early childhood. In this review, we propose to present the effects of healthy lifestyle strategies, including physical exercise and dietary approaches, on the management of IR and related metabolic derangements. All types of exercise (aerobic, resistance and combined training) effectively reduce IR in pediatric patients with obesity; it seems that aerobic and combined training stimulate greater improvements in IR compared to resistance training. Balanced normocaloric or hypocaloric dietary approaches are also valid strategies to address IR; it is not possible to assess the long-term impact of varying macronutrients on cardiometabolic risk. The glycemic index/load evaluation is a useful dietary approach to glucose metabolism control. Similarly, they should adopt the principle of the Mediterranean diet. Randomized studies with longer monitoring are needed to define the benefits of nutritional supplementation on IR. Considering that healthy style acquisition could track to later ages, programs of healthy lifestyle starting with children offer a better preventive strategy to preserve metabolic control and children’s health.
Not Another Caffeine Effect on Sports Performance Study—Nothing New or More to Do?
Authors: Tallis Jason , Guimaraes-Ferreira Lucas , Clarke Neil D.
Published: November 2022

The performance-enhancing potential of acute caffeine consumption is firmly established with benefits for many aspects of physical performance and cognitive function summarised in a number of meta-analyses. Despite this, there remains near exponential growth in research articles examining the ergogenic effects of caffeine. Many such studies are confirmatory of well-established ideas, and with a wealth of convincing evidence available, the value of further investigation may be questioned. However, several important knowledge gaps remain. As such, the purpose of this review is to summarise key knowledge gaps regarding the current understanding of the performance-enhancing effect of caffeine and justify their value for future investigation. The review will provide a particular focus on ten research priorities that will aid in the translation of caffeine’s ergogenic potential to real-world sporting scenarios. The discussion presented here is therefore essential in guiding the design of future work that will aid in progressing the current understanding of the effects of caffeine as a performance enhancer.
Sagnac Interferometric Temperature Sensor Based on Boron-Doped Polarization-Maintaining Photonic Crystal Fibers
Authors: Cheng Lan , Liang Jun , Xie Shiwei , Tong Yilin
Published: November 2022

A sensitive temperature sensor was demonstrated using boron-doped polarization-maintaining photonic crystal fiber (PM-PCF) as a Sagnac interferometer (SI). This boron-doped PM-PCF combines both the geometric birefringence introduced by the PCF structure design and the stress birefringence introduced by the boron-doped stress-applying parts. However, we found that the stress birefringence dominates the total birefringence of the sensor by numerical analysis. In the experiments, the fabricated sensor exhibited the highest temperature sensitivity of −1.83 nm/°C within the wide temperature range of 28~76 °C. The temperature sensitivity was mainly derived from the stress birefringence of boron-doped PM-PCF SI. These findings provide some support for the designation of high-precision temperature sensors.
Genetic Characterization of the Poultry Red Mite (Dermanyssus gallinae) in Poland and a Comparison with European and Asian Isolates
Authors: Koziatek-Sadłowska Sylwia , Sokół Rajmund
Published: November 2022

(1) Background: The blood-feeding mite Dermanyssus gallinae (De Geer 1778) continues to attract wide interest from researchers and bird breeders. The aim of this study was to evaluate the genetic diversity of D. gallinae populations in five commercial laying hen farms in Poland and to determine their similarity with isolates from other countries. The study involved an analysis of a fragment of the cytochrome c oxidase subunit I gene (COI). A total of 38 isolates obtained from Polish farms and 338 sequences deposited in GenBank were analyzed. (2) Results: Haplotype No. 46 was dominant (90%) in Polish isolates and was homologous with the isolates from Great Britain, the Netherlands, Belgium, Japan, and South Korea. These results are indicative of high genetic homogeneity and common ancestry of the poultry red mite and point to a common source of infestation in the examined farms. (3) Conclusions: The genetic diversity of D. gallinae should be further studied to promote a better understanding of how this parasite is disseminated within and between countries.
Insight into the Prospects for Tumor Therapy Based on Photodynamic Immunotherapy
Authors: Cheng Xiaoxia , Wei Yiqu , Jiang Xiaomei , Wang Chunli , Liu Mengyu , Yan Jiaxin , Zhang Lei , Zhou Yaqi
Published: November 2022

Malignancy is one of the common diseases with high mortality worldwide and the most important obstacle to improving the overall life expectancy of the population in the 21st century. Currently, single or combined treatments, including surgery, chemotherapy, and radiotherapy, are still the mainstream regimens for tumor treatment, but they all present significant side effects on normal tissues and organs, such as organ hypofunction, energy metabolism disorders, and various concurrent diseases. Based on this, theranostic measures for the highly selective killing of tumor cells have always been a hot area in cancer-related fields, among which photodynamic therapy (PDT) is expected to be an ideal candidate for practical clinical application due to its precise targeting and excellent safety performance, so-called PDT refers to a therapeutic method mainly composed of photosensitizers (PSs), laser light, and reactive oxygen species (ROS). Photoimmunotherapy (PIT), a combination of PDT and immunotherapy, can induce systemic antitumor immune responses and inhibit continuing growth and distant metastasis of residual tumor cells, demonstrating a promising application prospect. This article reviews the types of immune responses that occur in the host after PDT treatment, including innate and adaptive immunity. To further help PIT-related drugs improve their pharmacokinetic properties and bioavailability, we highlight the potential improvement of photodynamic immunotherapy from three aspects: immunostimulatory agents, tumor-associated antigens (TAAs) as well as different immune cells. Finally, we focus on recent advances in various strategies and shed light on their corresponding mechanisms of immune activation and possible clinical applications such as cancer vaccines. Having discovered the inherent potential of PDT and the mechanisms that PDT triggers host immune responses, a variety of immunotherapeutic strategies have been investigated in parallel with approaches to improve PDT efficiency. However, it remains to be further elucidated under what conditions the immune effect induced by PDT can achieve tumor immunosuppression and to what extent PDT-induced antitumor immunity will lead to complete tumor rejection. Currently, PIT presents several outstanding intractable challenges, such as the aggregation ability of PSs locally in tumors, deep tissue penetration ability of laser light, immune escape, and biological toxicity, and it is hoped that these issues raised will help to point out the direction of preclinical research on PIT and accelerate its transition to clinical practice.
Phytochemicals Targeting Ferroptosis: Therapeutic Opportunities and Prospects for Treating Breast Cancer
Authors: Zhao Xinyi , Wang Xueni , Pang Yuzhou
Published: November 2022

Ferroptosis, a recently discovered iron-dependent regulated cell death, has been implicated in the therapeutic responses of various cancers including breast cancer, making it a promising therapeutic target to manage this malignancy. Phytochemicals are conventional sources for medication development. Some phytochemicals have been utilized therapeutically to treat cancers as pharmaceutic agents or dietary supplements. Intriguingly, a considerable number of antitumor drugs derived from phytochemicals have been proven to be targeting ferroptosis, thus producing anticancer effects. In this review, we provide a short overview of the interaction between core ferroptosis modulators and breast cancer, illustrating how ferroptosis affects the destiny of breast cancer cells. We also systematically summarize the regulatory effects of phytochemicals on ferroptosis and emphasize their clinical applications in breast cancer suppression, which may accelerate the development of their therapeutic use in breast cancer.
The Anti-Melanoma Effect of Betulinic Acid Functionalized Gold Nanoparticles: A Mechanistic In Vitro Approach
Authors: Ghiulai Roxana , Mioc Alexandra , Racoviceanu Roxana , Mioc Marius , Milan Andreea , Prodea Alexandra , Semenescu Alexandra , Dehelean Cristina , Barbu Tudoran Lucian , Avram Ștefana , Trandafirescu Cristina , Șoica Codruța
Published: November 2022

Implementing metallic nanoparticles as research instruments for the transport of therapeutically active compounds remains a fundamentally vital work direction that can still potentially generate novelties in the field of drug formulation development. Gold nanoparticles (GNP) are easily tunable carriers for active phytocompounds like pentacyclic triterpenes. These formulations can boost the bioavailability of a lipophilic structure and, in some instances, can also enhance its therapeutic efficacy. In our work, we proposed a biological in vitro assessment of betulinic acid (BA)-functionalized GNP. BA-GNP were obtained by grafting BA onto previously synthesized citrate-capped GNP through the use of cysteamine as a linker. The nanoformulation was tested in HaCaT human keratinocytes and RPMI-7951 human melanoma cells, revealing selective cytotoxic properties and stronger antiproliferative effects compared to free BA. Further examinations revealed a pro-apoptotic effect, as evidenced by morphological changes in melanoma cells and supported by western blot data showing the downregulation of anti-apoptotic Bcl-2 expression coupled with the upregulation of pro-apoptotic Bax. GNP also significantly inhibited mitochondrial respiration, confirming its mitochondrial-targeted activity.