bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated Transcriptome and Molecular Docking to Identify the Hub Superimposed Attenuation Targets of Curcumin in Breast Cancer Cells
Authors: Wang Rui , Yu Hao , Chen Peide , Yuan Ting , Zhang Jing
Published: August 2023

Numerous in vitro and in vivo studies have shown that curcumin primarily activates apoptotic pathways in cancer cells and inhibits cancer progression by modulating various molecular targets. In this study, we utilized reverse docking servers to predict 444 human proteins that may potentially be targeted by curcumin. Then, high-throughput assays were conducted by using RNA-seq technology on curcumin-treated MCF-7 (human breast cancer ER (+)) and MDA-MB-231 (human breast cancer ER(-)/TNBC) cancer cell lines. Enrichment analysis identified seven and eight significantly down-regulated signaling pathways in these two cell lines, where the enriched genes were used to construct protein–protein interaction networks. From these networks, the MCODE algorithm screened out 42 hub targets, which are core genes of the RTK-(PI3K-AKT)/(MEK/ERK1/2) crosstalk network. Genetic alteration and expression patterns of hub targets of curcumin may be closely related to the overall pathogenesis and prognosis of breast cancer. MAPKAPK3, AKT3, CDK5, IGF1R, and MAPK11 are potential prognostic markers and therapeutic targets of curcumin in patients with triple-negative breast cancer. Molecular docking and transcriptomic results confirmed that curcumin can inhibit these high-scoring targets at the protein level. Additionally, these targets can act as self-feedback factors, relying on the cascading repressive effects in the network to limit their own transcription at the mRNA level. In conclusion, the integration of transcriptomic and molecular docking approaches enables the rapid identification of dual or multiple inhibitory targets of curcumin in breast cancer. Our study provides the potential elucidation of the anti-cancer mechanism of curcumin.
Clinical Applications for Gasotransmitters in the Cardiovascular System: Are We There Yet?
Authors: Arrigo Elisa , Comità Stefano , Pagliaro Pasquale , Penna Claudia , Mancardi Daniele
Published: August 2023

Ischemia is the underlying mechanism in a wide variety of acute and persistent pathologies. As such, understanding the fine intracellular events occurring during (and after) the restriction of blood supply is pivotal to improving the outcomes in clinical settings. Among others, gaseous signaling molecules constitutively produced by mammalian cells (gasotransmitters) have been shown to be of potential interest for clinical treatment of ischemia/reperfusion injury. Nitric oxide (NO and its sibling, HNO), hydrogen sulfide (H2S), and carbon monoxide (CO) have long been proven to be cytoprotective in basic science experiments, and they are now awaiting confirmation with clinical trials. The aim of this work is to review the literature and the clinical trials database to address the state of development of potential therapeutic applications for NO, H2S, and CO and the clinical scenarios where they are more promising.
From Acid Alpha-Glucosidase Deficiency to Autophagy: Understanding the Bases of POMPE Disease
Authors: Sánchez-Porras Valentina , Guevara-Morales Johana Maria , Echeverri-Peña Olga Yaneth
Published: August 2023

Pompe disease (PD) is caused by mutations in the GAA gene, which encodes the lysosomal enzyme acid alpha-glucosidase, causing lysosomal glycogen accumulation, mainly in muscular tissue. Autophagic buildup is considered the main factor affecting skeletal muscle, although other processes are also involved. Uncovering how these mechanisms are interconnected could be an approximation to address long-lasting concerns, like the differential skeletal and cardiac involvement in each clinical phenotype. In this sense, a network reconstruction based on a comprehensive literature review of evidence found in PD enriched with the STRING database and other scientific articles is presented. The role of autophagic lysosome reformation, PGC-1α, MCOLN1, calcineurin, and Keap1 as intermediates between the events involved in the pathologic cascade is discussed and contextualized within their relationship with mTORC1/AMPK. The intermediates and mechanisms found open the possibility of new hypotheses and questions that can be addressed in future experimental studies of PD.
IL-23/IL-17 Axis in Chronic Hepatitis C and Non-Alcoholic Steatohepatitis—New Insight into Immunohepatotoxicity of Different Chronic Liver Diseases
Authors: Vujovic Ankica , Isakovic Andjelka M. , Misirlic-Dencic Sonja , Juloski Jovan , Mirkovic Milan , Cirkovic Andja , Djelic Marina , Milošević Ivana
Published: August 2023

Considering the relevance of the research of pathogenesis of different liver diseases, we investigated the possible activity of the IL-23/IL-17 axis on the immunohepatotoxicity of two etiologically different chronic liver diseases. A total of 36 chronic hepatitis C (CHC) patients, 16 with (CHC-SF) and 20 without significant fibrosis (CHC-NSF), 19 patients with non-alcoholic steatohepatitis (NASH), and 20 healthy controls (CG) were recruited. Anthropometric, biochemical, and immunological cytokines (IL-6, IL-10, IL-17 and IL-23) tests were performed in accordance with standard procedure. Our analysis revealed that a higher concentration of plasma IL-23 was associated with NASH (p = 0.005), and a higher concentration of plasma IL-17A but a lower concentration of plasma IL-10 was associated with CHC in comparison with CG. A lower concentration of plasma IL-10 was specific for CHC-NSF, while a higher concentration of plasma IL-17A was specific for CHC-SF in comparison with CG. CHC-NSF and CHC-SF groups were distinguished from NASH according to a lower concentration of plasma IL-17A. Liver tissue levels of IL-17A and IL-23 in CHC-NSF were significantly lower in comparison with NASH, regardless of the same stage of the liver fibrosis, whereas only IL-17A tissue levels showed a difference between the CHC-NSF and CHC-SF groups, namely, a lower concentration in CHC-NSF in comparison with CHC-SF. In CHC-SF and NASH liver tissue, IL17-A and IL-23 were significantly higher in comparison with plasma. Diagnostic accuracy analysis showed significance only in the concentration of plasma cytokines. Plasma IL-6, IL-17A and IL-23 could be possible markers that could differentiate CHC patients from controls. Plasma IL-23 could be considered a possible biomarker of CHC-NSF patients in comparison with controls, while plasma IL-6 and IL-17-A could be biomarkers of CHC-SF patients in comparison with controls. The most sophisticated difference was between the CHC-SF and CHC-NSF groups in the plasma levels of IL-10, which could make this cytokine a useful biomarker of liver fibrosis.
Arrhythmias in Patients with Cardiac Amyloidosis: A Comprehensive Review on Clinical Management and Devices
Authors: Briasoulis Alexandros , Kourek Christos , Papamichail Adamantia , Loritis Konstantinos , Bampatsias Dimitrios , Repasos Evangelos , Xanthopoulos Andrew , Tsougos Elias , Paraskevaidis Ioannis
Published: August 2023

Cardiac amyloidosis (CA) is a rare but potentially life-threatening disease in which misfolded proteins accumulate in the cardiac wall tissue. Heart rhythm disorders in CA, including supraventricular arrhythmias, conduction system disturbances, or ventricular arrhythmias, play a major role in CA morbidity and mortality, and thus require supplementary management. Among them, AF is the most frequent arrhythmia during CA hospitalizations and is associated with significantly higher mortality, while ventricular arrhythmias are also common and are usually associated with poor prognosis. Early diagnosis of potential arrythmias could be performed through ECG, Holter monitoring, and/or electrophysiology study. Clinical management of these patients is quite significant, and it usually includes initiation of amiodarone and/or digoxin in patients with AF, potential electrical cardioversion, or ablation in specific patients with indication, as well as initiation of anticoagulants in all patients, independent of AF and CHADS-VASc score, for potential intracardiac thrombus. Moreover, identification of patients with conduction disorders that could benefit from prophylactic pacemaker implantation and/or CRT as well as identification of patients with life-threatening ventricular arrythmias that could benefit from ICD could both increase the survival rates of these patients and improve their quality of life.
It Sounds like It Feels: Preliminary Exploration of an Aeroacoustic Diagnostic Protocol for Singers
Authors: Baker Calvin Peter , Purdy Suzanne C. , Rakena Te Oti , Bonnini Stefano
Published: August 2023

To date, no established protocol exists for measuring functional voice changes in singers with subclinical singing-voice complaints. Hence, these may go undiagnosed until they progress into greater severity. This exploratory study sought to (1) determine which scale items in the self-perceptual Evaluation of Ability to Sing Easily (EASE) are associated with instrumental voice measures, and (2) construct as proof-of-concept an instrumental index related to singers’ perceptions of their vocal function and health status. Eighteen classical singers were acoustically recorded in a controlled environment singing an /a/ vowel using soft phonation. Aerodynamic data were collected during a softly sung /papapapapapapa/ task with the KayPENTAX Phonatory Aerodynamic System. Using multi and univariate linear regression techniques, CPPS, vibrato jitter, vibrato shimmer, and an efficiency ratio (SPL/PSub) were included in a significant model (p < 0.001) explaining 62.4% of variance in participants’ composite scores of three scale items related to vocal fatigue. The instrumental index showed a significant association (p = 0.001) with the EASE vocal fatigue subscale overall. Findings illustrate that an aeroacoustic instrumental index may be useful for monitoring functional changes in the singing voice as part of a multidimensional diagnostic approach to preventative and rehabilitative voice healthcare for professional singing-voice users.
Complement Inhibitors for Advanced Dry Age-Related Macular Degeneration (Geographic Atrophy): Some Light at the End of the Tunnel?
Authors: Cruz-Pimentel Miguel , Wu Lihteh
Published: August 2023

Geographic atrophy (GA) affects around 5 million individuals worldwide. Genome-wide, histopathologic, in vitro and animal studies have implicated the activation of the complement system and chronic local inflammation in the pathogenesis of GA. Recently, clinical trials have demonstrated that an intravitreal injection of pegcetacoplan, a C3 inhibitor, and avacincaptad pegol, a C5 inhibitor, both statistically significantly reduce the growth of GA up to 20% in a dose-dependent fashion. Furthermore, the protective effect of both pegcetacoplan and avacincaptad appear to increase with time. However, despite these anatomic outcomes, visual function has not improved as these drugs appear to only slow down the degenerative process. Unexpected adverse events included conversion to exudative NV-AMD with both drugs. Occlusive retinal vasculitis and anterior ischemic optic neuropathy have been reported in pegcetacoplan-treated eyes.
Abdominal Imaging in ADPKD: Beyond Total Kidney Volume
Authors: Caroli Anna , Kline Timothy L.
Published: August 2023

In the context of autosomal dominant polycystic kidney disease (ADPKD), measurement of the total kidney volume (TKV) is crucial. It acts as a marker for tracking disease progression, and evaluating the effectiveness of treatment strategies. The TKV has also been recognized as an enrichment biomarker and a possible surrogate endpoint in clinical trials. Several imaging modalities and methods are available to calculate the TKV, and the choice depends on the purpose of use. Technological advancements have made it possible to accurately assess the cyst burden, which can be crucial to assessing the disease state and helping to identify rapid progressors. Moreover, the development of automated algorithms has increased the efficiency of total kidney and cyst volume measurements. Beyond these measurements, the quantification and characterization of non-cystic kidney tissue shows potential for stratifying ADPKD patients early on, monitoring disease progression, and possibly predicting renal function loss. A broad spectrum of radiological imaging techniques are available to characterize the kidney tissue, showing promise when it comes to non-invasively picking up the early signs of ADPKD progression. Radiomics have been used to extract textural features from ADPKD images, providing valuable information about the heterogeneity of the cystic and non-cystic components. This review provides an overview of ADPKD imaging biomarkers, focusing on the quantification methods, potential, and necessary steps toward a successful translation to clinical practice.
A Japanese Prospective, Multicenter Study of Colonic Stenting for Palliation Using a High Axial Force Self-Expandable Metal Stent for Malignant Large Bowel Obstruction in 200 Patients
Authors: Ishibashi Rei , Sasaki Takashi , Isayama Hiroyuki , Matsuzawa Takeaki , Kuwai Toshio , Yamada Tomonori , Saito Shuji , Tomita Masafumi , Shiratori Toshiyasu , Ikeda Satoshi , Kanazawa Hideki , Fujishiro Mitsuhiro , Maetani Iruru , Saida Yoshihisa
Published: August 2023

Evidence of the efficacy and safety of colorectal stent placement for palliation remains insufficient. This single-arm, prospective, multicenter study with a WallFlex enteral colonic stent included 200 consecutive patients with malignant large bowl obstruction in the palliation cohort. The technical and clinical success, as well as stent patency and complications as short-term (≤7 days) and long-term (>7 days) outcomes, of high axial force self-expandable metal stent (SEMS) placement was evaluated. The technical and clinical success rates were 98.5% and 94.5%, respectively. Non-recurrent colorectal obstruction at 1 year was 63.9%, and 71.2% of the patients remained free of recurrent colorectal obstruction until death or the last follow-up. Fifty-six patients (28.0%) received chemotherapy, and five patients were administered bevacizumab after stent placement. The overall complication rate was 47%, including four (2.0%) early-onset and ten (5.0%) late-onset perforations, mostly due to stent-edge injury. Only the use of a long SEMS was a risk factor for perforation. In conclusion, endoscopic colorectal stenting using high axial force SEMS is an effective and safe procedure for palliation in patients with malignant colorectal obstruction. However, care should be taken to avoid perforation at the stent edge when using a long SEMS.
MRI and Pulmonary Function Tests’ Results as Ventilation Inhomogeneity Markers in Children and Adolescents with Cystic Fibrosis
Authors: Wojsyk-Banaszak Irena , Więckowska Barbara , Szczepankiewicz Aleksandra , Stachowiak Zuzanna , Andrzejewska Marta , Juchnowicz Jerzy , Kycler Maciej , Famulska Paulina , Osińska Marta , Jończyk-Potoczna Katarzyna
Published: August 2023

Magnetic resonance imaging (MRI) of the chest is becoming more available in the detection and monitoring of early changes in lung function and structure in patients with cystic fibrosis (CF). The aim of this study was to assess the relationship between pulmonary function tests (PFT) and perfusion deficits in CF children measured by MRI. We performed a retrospective analysis of the perfusion lung MRI scans and the results of spirometry, oscillometry, body plethysmography, single-breath carbon monoxide uptake, and multiple-breath washout technique (MBW). There were statistically significant correlations between the MRI perfusion scores and MBW parameters (2.5% LCI, M1/M0, M2/M0), spirometry parameters (FEV1, FVC, FEF25/75), reactance indices in impulse oscillometry (X5Hz, X10Hz), total lung capacity (TLC) measured in single breath carbon monoxide uptake, markers of air-trapping in body plethysmography (RV, RV/TLC), and the diffusing capacity of the lungs for carbon monoxide. We also observed significant differences in the aforementioned PFT variables between the patient groups divided based on perfusion scores. We noted a correlation between markers of functional lung deficits measured by the MRI and PFTs in CF children. MRI perfusion abnormalities were reflected sooner in the course of the disease than PFT abnormalities.
Influence of Physical Activity during Pregnancy on Type and Duration of Delivery, and Epidural Use: Systematic Review and Meta-Analysis
Authors: Zhang Dingfeng , Ruchat Stephanie-May , Silva-Jose Cristina , Gil-Ares Javier , Barakat Rubén , Sánchez-Polán Miguel
Published: August 2023

Cesarean delivery may increase the need for anesthesia administration, thereby causing potential risks to both maternal and fetal health. This article aimed to investigate the effect of physical activity during pregnancy on the type of delivery, the duration of labor, and the use of epidurals (registration No.: CRD42022370646). Furthermore, 57 RCTs (n = 15301) were included showing that physical activity could decrease the risk of cesarean section (z = 3.22, p = 0.001; RR = 0.87, 95% CI = 0.79, 0.95, I2 = 37%, Pheterogeneity = 0.004), and 32 RCTs (n = 9468) showed significant decreases in instrumental delivery through performing physical activity (z = 3.48, p < 0.001; RR = 0.84, 95% CI = 0.76, 0.93, I2 = 0%, Pheterogeneity = 0.63). A significant decrease in the 15 RCTs’ (n = 4797) duration of first stage labor was found in physically active pregnant women (z = 2.09, p = 0.04; MD = −62.26, 95% CI = −120.66, −3.85, I2 = 93%, Pheterogeneity < 0.001) compared to those not active. Prenatal physical activity could decrease the risk of cesarean section and instrumental delivery and the duration of first stage labor.
The Relationship between Hypertension and Periodontitis: A Cross-Sectional Study
Authors: Rosa Rossana Abud Cabrera , Rodrigues João Victor Soares , Cláudio Marina Module , Franciscon João Paulo Soares , Mulinari-Santos Gabriel , Cirelli Thamiris , de Molon Rafael Scaf , Gouveia Garcia Valdir , Theodoro Leticia Helena
Published: August 2023

Recent evidence suggests an association between hypertension and periodontitis, although the pathways and implications underlying both chronic conditions are still poorly understood. Therefore, the aim of this study was to evaluate the relationship between hypertension and periodontitis through an observational clinical study using periodontal, physical, and biochemical analyses in hypertensive and non-hypertensive individuals with periodontitis. A total of one hundred patients were divided into two groups. The first group was hypertensive patients with periodontitis. The second group was non-hypertensive patients with periodontitis. Periodontal parameters of probing depth, bleeding on probing, and clinical attachment level were evaluated. The systolic, diastolic, mean, and differential blood pressure were measured in the physical examination. In addition, body mass index and waist–hip ratio were verified. Biochemical tests for glycated hemoglobin, fasting blood glucose, estimated blood glucose, total cholesterol, high-density lipoprotein, creatinine, glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, and C-reactive protein were evaluated. The data were submitted for statistical analysis (α = 0.05%). The results of this study demonstrated that patients with cardiovascular disease did not present with worse periodontal clinical parameters in the conditions studied. However, it is important to bear in mind that this cross-sectional study has some inherent limitations to its design; therefore, to study the relationship between hypertension and periodontitis further, an interventional randomized clinical trial should be conducted.
Autonomous Vehicles: Sophisticated Attacks, Safety Issues, Challenges, Open Topics, Blockchain, and Future Directions
Authors: Giannaros Anastasios , Karras Aristeidis , Theodorakopoulos Leonidas , Karras Christos , Kranias Panagiotis , Schizas Nikolaos , Kalogeratos Gerasimos , Tsolis Dimitrios
Published: August 2023

Autonomous vehicles (AVs), defined as vehicles capable of navigation and decision-making independent of human intervention, represent a revolutionary advancement in transportation technology. These vehicles operate by synthesizing an array of sophisticated technologies, including sensors, cameras, GPS, radar, light imaging detection and ranging (LiDAR), and advanced computing systems. These components work in concert to accurately perceive the vehicle’s environment, ensuring the capacity to make optimal decisions in real-time. At the heart of AV functionality lies the ability to facilitate intercommunication between vehicles and with critical road infrastructure—a characteristic that, while central to their efficacy, also renders them susceptible to cyber threats. The potential infiltration of these communication channels poses a severe threat, enabling the possibility of personal information theft or the introduction of malicious software that could compromise vehicle safety. This paper offers a comprehensive exploration of the current state of AV technology, particularly examining the intersection of autonomous vehicles and emotional intelligence. We delve into an extensive analysis of recent research on safety lapses and security vulnerabilities in autonomous vehicles, placing specific emphasis on the different types of cyber attacks to which they are susceptible. We further explore the various security solutions that have been proposed and implemented to address these threats. The discussion not only provides an overview of the existing challenges but also presents a pathway toward future research directions. This includes potential advancements in the AV field, the continued refinement of safety measures, and the development of more robust, resilient security mechanisms. Ultimately, this paper seeks to contribute to a deeper understanding of the safety and security landscape of autonomous vehicles, fostering discourse on the intricate balance between technological advancement and security in this rapidly evolving field.
Investigation of Solar Air Collectors with Carbon-Nanotube-Based Turbulators and Pin Fin Arrangements
Authors: Appadurai M. , Raj E. Fantin Irudaya , Ram Vishal , Gnaniah Augustine Mathu , Salkuti Surender Reddy , Kim Seong-Cheol
Published: August 2023

This research attempts to investigate the thermal performance of solar air collectors with pin fins and turbulators. Incorporating carbon-nanotube-based fins and turbulators in solar collectors can enhance their performance due to their high thermal conductivity, low weight, and high aspect ratio. In the present study, numerical analyses of a solar collector with pin fins and turbulators are carried out to investigate its effect on the Nusselt number. The paper begins with the numerical analysis of conventional air collectors and compares them with theoretical results. This is followed by numerical analyses, which are carried out to examine different configurations of the absorber plate with pin fins of varying diameters (10 mm, 20 mm, and 30 mm) and turbulators of varying heights (20 mm, 40 mm, and 60 mm) in the base plate. The analyses include variations in the Reynolds number ranging from 3000 to 15,000. Subsequently, after the performance of the solar collector with pin fins is evaluated, the effect of turbulators of varying heights on the Nusselt number is analyzed, followed by the analysis of the combined effect of pin fins and turbulators. The results are compared with traditional solar collectors and show that the combined effect of pin fins and turbulators can significantly improve the thermal performance of solar air collectors. The findings of this study can contribute to the development of renewable energy-based air conditioning, ventilation, and heating systems.
Fabrication and Characterization of Electrospun Chitosan/Polylactic Acid (CH/PLA) Nanofiber Scaffolds for Biomedical Application
Authors: Samokhin Yevhen , Varava Yuliia , Diedkova Kateryna , Yanko Ilya , Husak Yevheniia , Radwan-Pragłowska Julia , Pogorielova Oksana , Janus Łukasz , Pogorielov Maksym , Korniienko Viktoriia
Published: August 2023

The present study demonstrates a strategy for preparing porous composite fibrous materials with superior biocompatibility and antibacterial performance. The findings reveal that the incorporation of PEG into the spinning solutions significantly influences the fiber diameters, morphology, and porous area fraction. The addition of a hydrophilic homopolymer, PEG, into the Ch/PLA spinning solution enhances the hydrophilicity of the resulting materials. The hybrid fibrous materials, comprising Ch modified with PLA and PEG as a co-solvent, along with post-treatment to improve water stability, exhibit a slower rate of degradation (stable, moderate weight loss over 16 weeks) and reduced hydrophobicity (lower contact angle, reaching 21.95 ± 2.17°), rendering them promising for biomedical applications. The antibacterial activity of the membranes is evaluated against Staphylococcus aureus and Escherichia coli, with PEG-containing samples showing a twofold increase in bacterial reduction rate. In vitro cell culture studies demonstrated that PEG-containing materials promote uniform cell attachment, comparable to PEG-free nanofibers. The comprehensive evaluation of these novel materials, which exhibit improved physical, chemical, and biological properties, highlights their potential for biomedical applications in tissue engineering and regenerative medicine.
Model Experimental Study on a T-Foil Control Method with Anti-Vertical Motion Optimization of the Mono Hull
Authors: Sun Yifang , Zhang Dapeng , Wang Yiqun , Zong Zhi , Wu Zongduo
Published: August 2023

T-foils with active control systems can adjust their attack angle according to the movement of the ship in real time, providing higher lift force and improving the seakeeping performance of a ship. The optimization of the control signal and that of the control method have an important influence on the effect of active T-foils. In this paper, the control method of the T-foil’s swinging angle is established and optimized on the basis of model testing in order to increase the effect of the T-foil. First, the governing equation is introduced by establishing the proportional relationship between the angular motion of the hull and the lift moment of the T-foil. On the basis of the model of the T-foil’s lift force, the governing equation of the T-foil’s swinging angle is deduced and simplified using the test results of the ship model with a passive T-foil and without a T-foil. Then, the active T-foil control system is established by comparing the effects of T-foils with different control signals. Finally, the efficacies of the passive and active T-foil are reported and discussed. It is found that the pitch angular velocity is a more appropriate signal than the pitch angle and pitch angular acceleration. T-foils with pitch angular velocity control can decrease the vertical motion response in the resonance region of a ship’s encounter frequency by more than about 20% compared to the case of the bare ship model, while also increasing the anti-bow acceleration effect by more than 15% compared to the case of passive control. The results obtained by model testing have a certain guiding significance for specific engineering practices.
Marine Oil Spill Detection from Low-Quality SAR Remote Sensing Images
Authors: Dong Xiaorui , Li Jiansheng , Li Bing , Jin Yueqin , Miao Shufeng
Published: August 2023

Oil spills pose a significant threat to the marine ecological environment. The intelligent interpretation of synthetic aperture radar (SAR) remote sensing images serves as a crucial approach to marine oil spill detection, offering the potential for real-time, continuous, and accurate monitoring. This study makes valuable contributions to the field of marine oil spill detection based on low-quality SAR images, focusing on the following key aspects: (1) We thoroughly analyze the Deep SAR Oil Spill dataset, known as the SOS dataset, a prominent resource in the domain of marine oil spill detection from low-quality SAR images, and rectify identified issues to ensure its reliability. (2) By identifying and rectifying errors in the original literature that presented the SOS dataset, and reproducing the experiments to provide accurate results, benchmark performance metrics for marine oil spill detection with low-quality SAR remote sensing images are established. (3) We propose three progressive deep learning-based marine oil spill detection methods (a direct detection method based on Transformer and UNet, a detection method based on FFDNet and TransUNet with denoising before detection, and a detection method based on integrated multi-model learning) and the performance advantages of the proposed methods are verified by comparing them with semantic segmentation models such as UNet, SegNet, and DeepLabV3+. (4) We introduce a feasible, highly robust and easily scalable system architecture approach that effectively addresses practical engineering applications. This paper is an important addition to the research on marine oil spill detection from low-quality SAR images, and the proposed experimental method and performance details can provide a reference for related research.
An Analytic Model for Identifying Real-Time Anchorage Collision Risk Based on AIS Data
Authors: Liu Zihao , Zhou Dan , Zheng Zhongyi , Wu Zhaolin , Gang Longhui
Published: August 2023

With the increasing volume of ship traffic, maritime traffic safety is facing a great challenge because the traffic in port becomes more and more crowded and complicated, which will make ship collisions more likely to happen. As a special water area of the port, the anchorage is also threatened by collision risk all the time. For accurately assessing the collision risk in anchorage and its adjacent waters in real time, this paper proposed an analytic model based on Automatic Identification System (AIS) data. The proposed anchorage collision risk model was established in microscopic, macroscopic, and complexity aspects, which considered ship relative motion, anchorage characteristics, and ship traffic complexity, respectively. For validation, the AIS data of the anchorages near the Shandong Peninsular were used to carry out a series of experiments. The results show that the proposed model can identify the anchorage collision risk effectively and has an advantage in dealing with complicated scenarios. The proposed anchorage collision risk model can help maritime surveillance better monitor and organize the ship traffic near the port and provide mariners with a reference about the collision risk situation of the anchorage on their route, which are important to improving maritime traffic safety.
Autonomous Navigation Decision-Making Method for a Smart Marine Surface Vessel Based on an Improved Soft Actor–Critic Algorithm
Authors: Cui Zhewen , Guan Wei , Zhang Xianku , Zhang Cheng
Published: August 2023

In this study, an intelligent hybrid algorithm based on deep-reinforcement learning (DRL) is proposed to achieve autonomous navigation and intelligent collision avoidance for a smart autonomous marine surface vessel (SMASV). First, the kinematic model of the SMASV is used, and clauses 13 to 17 of the Convention on the International Regulations for Preventing Collisions at Sea (COLREGs) are introduced. Then, the electronic chart is rasterized and used for path planning. Next, states, actions, and reward functions are designed, and collision avoidance strategies are formulated. In addition, a temperature factor and a constrained loss function are used to improve the soft actor–critic (SAC) algorithm. This improvement reduces the challenges of hyperparameter adjustment and improves sampling efficiency. By comparing the improved SAC algorithm with other deep-reinforcement learning (DRL) algorithms based on strategy learning, it is proved that the improved SAC algorithm converges faster than the other algorithms. During the experiment, some unknown obstacles are added to the simulation environment to verify the collision-avoidance ability of the trained SMASV. Moreover, eight sea areas are randomly selected to verify the generalization ability of the intelligent-navigation system. The results show that the proposed method can plan a path for the SMASV accurately and effectively, and the SMASV decision-making behavior in the collision-avoidance process conforms to the COLREGs in both unknown and dynamic environments.
Adaptive Dynamics of Settlement Models in the Urban Landscape of Termez (Uzbekistan) from c. 300 BCE to c. 1400 CE
Authors: Ariño Enrique , Uribe Paula , Angás Jorge , Piqué Raquel , Portero Rodrigo , Martínez-Ferreras Verónica , Gurt Josep M.
Published: August 2023

The archaeological site of Ancient Termez is located in southern Uzbekistan. Despite the arid environment, the city benefited from its strategic position near two rivers, the Amu Darya and the Surkhan Darya. Its significance was mainly related to the expansion of trade routes connecting Eurasia. The city comprises several enclosures that attest long-term human-environment interactions. In order to identify the adaptive dynamics of the settlement models during an extended chronology covering the period from c. 300 BCE to c. 1220 CE (Greco-Bactrian/Yuezhi, Kushan, Kushano-Sasanian, and Islamic periods), a multidisciplinary study has been carried out, which includes: (1) archaeological excavations in several areas of the urban complex; (2) pedestrian surveying inside some enclosures and in the urban periphery; (3) an aerial survey based on high-resolution satellite imagery; (4) AMS dating of charcoal and bone samples; (5) archaeobotanical investigation through anthracological analysis; (6) zooarchaeological studies. The results point to variations in the development of the inhabited spaces, in which abandonment and occupation took place. The zooarchaeological and archaeobotanical data demonstrate the exploitation of natural resources in different environments (i.e., arid areas and irrigated land) and a certain evolution during the period considered.
A Multi-Criteria Analysis GIS Tool for Measuring the Vulnerability of the Residential Stock Based on Multidimensional Indices
Authors: Modrego-Monforte Itziar , Barrena-Herrán Mikel , Grijalba Olatz
Published: August 2023

There is extensive scientific evidence showing that the characteristics of the urban and residential environment directly affect people’s quality of life and health. In this framework, numerous building renovation policies have been developed in Europe, mainly focused on improving energy efficiency. However, we are dealing with a multifactorial and multicausal phenomenon of a complex system where competent institutions need quantitative diagnosis mechanisms that consider this holistic vision when making decisions and prioritizing interventions. Regarding this, the present research develops the potential of the multi-criteria methodology in a first proposal, which integrates social, energy, environmental and spatial aspects linked to the relationship between housing and the effects on the health of its inhabitants. It is a multidimensional method based on systematized and exportable vulnerability indices, which applies indicators that have been calculated using cadastral data and a typomorphological characterization of the residential stock. The analysis of the results through geostatistical techniques of autocorrelation and clustering applied to the case study of Donostia-San Sebastián shows that the proposed methodology is effective in achieving the objectives set. The associated GIS tool has proved to be agile and replicable.
Spatial Characteristics and Obstacle Factors of Cultivated Land Quality in an Intensive Agricultural Region of the North China Plain
Authors: Sun Xiaobing , Li Quanfeng , Kong Xiangbin , Cai Weimin , Zhang Bailin , Lei Ming
Published: August 2023

Cultivated land quality (CLQ) is at the core of the trinity protection of cultivated land in China. Scientific evaluation of CLQ and identification of its obstacle factors are the foundation for the construction and improvement of the quality of cultivated land. The main objective of this study was to evaluate CLQ and identify its obstacle factors, and Quzhou County, an intensive agricultural region in the North China Plain (NCP), was selected as a case study. The evaluation index system of CLQ was constructed based on five dimensions, including climate condition, topographic characteristic, soil property, farming status, and environmental condition, by analyzing the logical evolution of elements, processes, functions, and quality of cultivated land. A methodological system based on the Weighted Summation Method (WSM) and the “1 + X” model was developed to evaluate the CLQ. Then, the obstacle diagnosis model constructed based on the Cask Law and relevant academic studies was used to identify the obstacle factors of CLQ. The results showed that the proportion of high-, medium-, and low-quality cultivated land in Quzhou County was 36.19%, 33.60%, and 30.21%, respectively, and the average grade of CLQ was 2.97, which was considered to be at a medium level. Moran’s I of global spatial autocorrelation in Quzhou County was 0.8782, indicating a significant positive autocorrelation of the cultivated land quality index (CLQI). The main obstacle factors of CLQ in Quzhou County were soil profile constitution, irrigation guarantee rate, groundwater depth, and soil microbial biomass carbon. Therefore, based on the stable and dynamic characteristics of the obstacle factors, suggestions were provided to improve the quality of cultivated land in terms of strengthening the consolidation of cultivated land, transforming the concept of agricultural fertilization, and carrying out cultivated land recuperation. This study provides a new perspective on the cognition, evaluation, and identification of obstacle factors of CLQ, and the findings of this study can provide a reference for the consolidation and improvement of CLQ in the NCP.
The Spatiotemporal Evolution and Influencing Factors of the Ceramics Industry in Jingdezhen in the Last 40 Years
Authors: He Qinghua , Zheng Xin , Xiao Xin , Luo Lei , Lin Hui , He Shan
Published: August 2023

The ceramic industry has been vital to the city’s development and prosperity in Jingdezhen, but the development of the ceramics industry in Jingdezhen has been unclear since China’s economic reforms, which will become a bottleneck limiting the sustainable development of the city. This study explored the spatial agglomeration and spatiotemporal evolution of the ceramics industry in Jingdezhen from 1980 to 2020 using enterprise directory data. The study opted for a microscopic perspective and employed kernel density estimation and exploratory spatial data analysis to obtain the necessary results. It also analyzed the influencing factors using a Geodetector. The results show that the temporal evolution of the ceramics industry in Jingdezhen went through two stages from 1980 to 2020. The number of enterprises experienced exponential growth, with fluctuations. The spatial evolution of the ceramics industry transitioned from a “single-center” to a “double-center” model and further evolved into a “multi-center” model. Moreover, the spatial agglomeration of the ceramics industry underwent the process of “agglomeration-diffusion-polarization”, ultimately developing into four ceramic industrial agglomeration patterns in six hotspots. Agglomeration, historical, technological, policy, and transportation factors had positive effects on the evolution of the ceramics industry in Jingdezhen, with agglomeration being the top contributor. Likewise, there were obvious interactions between the factors. This study can provide a basis for formulating policies to support urban spatial planning for urban revitalization, and provide foundation for the development of the national ceramic culture inheritance and innovation pilot zone in Jingdezhen.
Hearing Children’s Objections in Hague Child Abduction Proceedings in England and Wales, Australia, and the USA
Authors: Fernando Michelle , Mant Jessica
Published: August 2023

In this article we compare how children’s objections to being returned to their country of origin are treated in Hague child abduction matters in three different international jurisdictions: England and Wales, Australia, and the United States. We examine the relevance of children’s views for the purposes of the ‘gateway’ stage of the relevant exception to mandatory return, and how children’s objections have been approached in legislation, case law, and scholarly commentary. We critique each jurisdiction’s approach against the objectives of the Hague Convention and the Convention on the Rights of the Child. We discuss how aspects such as the methods by which children are heard can make a difference to experiences for children and make recommendations to promote greater certainty and consistency in how children’s objections are heard and considered across jurisdictions.
The Role of Chronic Fatigue in Patients with Crohn’s Disease
Authors: Włodarczyk Marcin , Makaro Adam , Prusisz Mateusz , Włodarczyk Jakub , Nowocień Marta , Maryńczak Kasper , Fichna Jakub , Dziki Łukasz
Published: August 2023

Crohn’s disease (CD) is a chronic, relapsing disorder belonging to inflammatory bowel diseases (IBD). It is manifested by relapsing transmural inflammation found in any segment of the gastrointestinal tract. Chronic fatigue is a common and underrecognized symptom of CD for which the prevalence is much higher in the population of CD patients compared to the healthy population. It stems from an intricate web of interactions between various risk factors, and its pathophysiology is still not fully understood. The implementation of routine screening and a holistic, multidisciplinary approach involving psychological support may be crucial in the management of CD patients with chronic fatigue. There is currently no single intervention aimed at decreasing fatigue alone, and its treatment is especially difficult in patients with fatigue persisting despite clinical and endoscopic remission. Extensive research is still needed in order to be able to predict, prevent, identify, and ultimately treat fatigue associated with CD. The aim of this review is to summarize the knowledge on the etiology, diagnosis, and treatment of chronic fatigue in CD patients.
Disposable Duodenoscopes: Evidence and Open Issues
Authors: Conti Clara Benedetta , Cereatti Fabrizio , Salerno Raffaele , Grassia Roberto , Scaravaglio Miki , Laurenza Carmen , Dinelli Marco Emilio
Published: August 2023

Duodenoscope-related infections are a major concern in medicine and GI endoscopy, especially in fragile patients. Disposable duodenoscopes seem to be the right tool to minimize the problem: a good choice for patients with many comorbidities or with a high risk of carrying multidrug resistant bacteria. Urgent endoscopy could also be a good setting for the use of single-use duodenoscopes, especially when the risk of the infection cannot be evaluated. Their safety and efficacy in performing ERCP has been proven in many studies. However, randomized clinical trials and comparative large studies with reusable scopes are lacking. Moreover, the present early stage of their introduction on the market does not allow a large economical evaluation for each health system. Thus, accurate economical and safety comparisons with cap-disposable duodenoscopes are needed. Moreover, the environmental impact of single-use duodenoscopes should be carefully evaluated, considering the ongoing climate change. In conclusion, definitive guidelines are needed to choose wisely the appropriate patients for ERCP with disposable duodenoscopes as the complete switch to single-use duodenoscopes seems to be difficult, to date. Many issues are still open, and they need to be carefully evaluated in further, larger studies.
Effects of Machining Parameters of C45 Steel Applying Vegetable Lubricant with Minimum Quantity Cooling Lubrication (MQCL)
Authors: Makhesana Mayur A. , Bagga Prashant J. , Patel Kaushik M. , Taha-Tijerina Jose J.
Published: August 2023

One of the most significant performance indicators for measuring the machinability of materials is tool wear and surface roughness. Choosing the best combination of cutting parameters can help reduce production costs, which is what the manufacturing industry is interested in. At the same time, industries are always looking for an alternative to conventional flood cooling since its use creates an environmental burden and health concerns for the operators. Therefore, vegetable oil-based minimum quantity cooling lubrication (MQCL) is considered a cutting environment. Sunflower oil is utilized as base fluid in MQCL and applied to the cutting zone through a nozzle. The turning experiments are conducted on C45 material which is widely used in various industrial applications, including numerous automotive components. Since flood cooling is widely utilized in machining C45, it is the present-day need to assess alternative cooling and lubricating approaches to avoid the adverse effects of flood cooling. The Taguchi method was used in the present work to minimize surface roughness and tool wear. L9 orthogonal array was constructed, and experiments were performed on C45 steel using coated carbide cutting tools. The statistical approach is utilized to evaluate the effect of cutting parameters on output responses. The optimal cutting settings for cutting speed, feed, and depth of cut to minimize surface roughness are 100 m/min, 0.18 mm/rev, 0.150 mm, and 80 m/min, 0.18 mm/rev, and 0.150 mm for tool wear. According to the findings, cutting speed, feed rate, and depth of cut varied surface roughness by 1.9%, 78.3%, and 14.04%, and tool wear by around 43.8%, 37.9%, and 6.3%, respectively. The outcomes can be useful to metal-cutting industries to identify the combination of machining parameters with vegetable oil-based MQCL.
Novel Mesoporous and Multilayered Yb/N-Co-Doped CeO2 with Enhanced Oxygen Storage Capacity
Authors: Xu Yaohui , Gao Liangjuan , Wu Pingkeng , Ding Zhao
Published: August 2023

A cubic fluorite-type CeO2 with mesoporous multilayered morphology was synthesized by the solvothermal method followed by calcination in air, and its oxygen storage capacity (OSC) was quantified by the amount of O2 consumption per gram of CeO2 based on hydrogen temperature programmed reduction (H2–TPR) measurements. Doping CeO2 with ytterbium (Yb) and nitrogen (N) ions proved to be an effective route to improving its OSC in this work. The OSC of undoped CeO2 was 0.115 mmol O2/g and reached as high as 0.222 mmol O2/g upon the addition of 5 mol.% Yb(NO3)3∙5H2O, further enhanced to 0.274 mmol O2/g with the introduction of 20 mol.% triethanolamine. Both the introductions of Yb cations and N anions into the CeO2 lattice were conducive to the formation of more non-stoichiometric oxygen vacancy (VO) defects and reducible–reoxidizable Cen+ ions. To determine the structure performance relationships, the partial least squares method was employed to construct two linear functions for the doping level vs. lattice parameter and [VO] vs. OSC/SBET.