bluuebunny/crossref_metadata_2025 huggingface dataset:
Are Atypical Antipsychotics the Least Detrimental Alternative?
Authors: Breton Holly
Published: April 2021

Antipsychotics are typically used for the treatment of schizophrenia, bipolar disorder, and recently, treatment resistant major depressive disorder.  A significant, and very concerning, side effect present with first generation antipsychotics is extrapyramidal symptoms, which are disorders of movement. With the advent of atypical antipsychotics, also known as second-generation antipsychotics, these symptoms are purported to be much less frequent and pronounced than they were with the first generation medications.  Numerous hypotheses have been proposed as to why atypical antipsychotics produce fewer extrapyramidal symptoms compared to first generation antipsychotics, which this paper will review. Unfortunately, despite the fact that atypicals have reduced extrapyramidal symptoms in those taking antipsychotics, extrapyramidal symptoms are still an unpleasant and potentially dangerous side effect, which can be difficult to detect, and difficult, or even impossible, to treat.  Additionally, atypical antipsychotics result in other potentially very serious side effects, specifically and most commonly, metabolic syndrome, which can decrease life expectancy significantly. However, metabolic syndrome, unlike extrapyramidal symptoms, may be preventable in highly motivated and well-supported patients. Thus, this paper concludes that the benefits of the atypical antipsychotics (reduced extrapyramidal symptoms) outweigh the potential risks for the majority of patients.
Resource stewardship in Canadian undergraduate medical education
Authors: Sharma Sahil , Rowe Matthew
Published: April 2021

New research suggests Canadian physicians order more than 1,000,000 potentially unnecessary tests and treatments each year. Strategies to educate medical students about the CanMEDs Resource Stewardship directive and judicious testing practices can help the healthcare system manage fiscal stress and improve healthcare experiences for patients. This article outlines several strategies that can be implemented at the undergraduate medical education level through Choosing Wisely Canada’s Students and Trainees Advocating for Resource Stewardship (STARS) program. The educational strategies feature group-based learning, lecture integration, and supportive online modules. Educating medical students across the country about judicious testing can produce the generation of resource-conscientious doctors that healthcare’s increasingly tight budget demands.
Evidence-Based Nutritional Strategies to Enhance Athletic Performance
Authors: Schroeder Nicole
Published: April 2021

In today's digital era, nutritional information, and misinformation, is readily available for most people by media outlets, social media, and on-line streaming videos. Nutrition is of utmost interest because of its role in health, fitness, weight management, and athletic performance. Because of the public interest and information availability, qualified health care providers and exercise professionals can be an excellent source of evidence-based nutrition counseling for appropriate clients to improve overall health and athletic performance. The goal of this article is to provide a source of practitioner and client evidence-based education regarding nutritional strategies to improve athletic performance.
The Cocaine and Oxycodone Biobanks, Two Repositories from Genetically Diverse and Behaviorally Characterized Rats for the Study of Addiction
Authors: Carrette Lieselot L. G. , de Guglielmo Giordano , Kallupi Marsida , Maturin Lisa , Brennan Molly , Boomhower Brent , Conlisk Dana , Sedighim Sharona , Tieu Lani , Fannon McKenzie J. , Velarde Nathan , Martinez Angelica R , Kononoff Jenni , Kimbrough Adam , Simpson Sierra , Smith Lauren C. , Shankar Kokila , Ramirez Francisco J. , Chitre Apurva S. , Lin Bonnie , Polesskaya Oksana , Solberg Woods Leah C. , Palmer Abraham A. , George Olivier
Published: April 2021

The rat oxycodone and cocaine biobanks contain samples that vary by genotypes (by using genetically diverse genotyped HS rats), phenotypes (by measuring addiction-like behaviors in an advanced SA model), timepoints (samples are collected longitudinally before, during, and after SA, and terminally at three different timepoints in the addiction cycle: intoxication, withdrawal, and abstinence or without exposure to drugs through age-matched naive rats), samples collected (organs, cells, biofluids, feces), preservation (paraformaldehyde-fixed, snap-frozen, or cryopreserved) and application (proteomics, transcriptomics, microbiomics, metabolomics, epigenetics, anatomy, circuitry analysis, biomarker discovery, etc.

Substance use disorders (SUDs) are pervasive in our society and have substantial personal and socioeconomical costs. A critical hurdle in identifying biomarkers and novel targets for medication development is the lack of resources for obtaining biological samples with a detailed behavioral characterization of SUD. Moreover, it is nearly impossible to find longitudinal samples. As part of two ongoing large-scale behavioral genetic studies in heterogeneous stock (HS) rats, we have created two preclinical biobanks using well-validated long access (LgA) models of intravenous cocaine and oxycodone self-administration (SA) and comprehensive characterization of addiction-related behaviors. The genetic diversity in HS rats mimics diversity in the human population and includes individuals that are vulnerable or resilient to compulsive-like responding for cocaine or oxycodone. Longitudinal samples are collected throughout the experiment, before exposure to the drug, during intoxication, acute withdrawal, and protracted abstinence, and include naive, age-matched controls. Samples include, but are not limited to, blood plasma, feces and urine, whole brains, brain slices and punches, kidney, liver, spleen, ovary, testis, and adrenal glands. Three preservation methods (fixed in formaldehyde, snap-frozen, or cryopreserved) are used to facilitate diverse downstream applications such as proteomics, metabolomics, transcriptomics, epigenomics, microbiomics, neuroanatomy, biomarker discovery, and other cellular and molecular approaches. To date, >20,000 samples have been collected from over 1000 unique animals and made available free of charge to non-profit institutions throughhttps://www.cocainebiobank.org/andhttps://www.oxycodonebiobank.org/.
FARKLI MİKRODALGA GÜÇ SEVİYELERİNDE VE FARKLI FIRIN SICAKLIKLARINDA KURUTULAN HİBİSKUS ÇANAK YAPRAKLARININ KURUMA KARAKTERİSTİKLERİNİN VE BAZI FİZİKOKİMYASAL ÖZELLİKLERİNİN BELİRLENMESİ
Authors: DİNÇER Cüneyt , ÇINAR Ahu , ELMASULU Safinaz
Published: April 2021

Bu çalışmada farklı sıcaklıklarda (60, 70, 80 °C) fırında ve farklı mikrodalga güç seviyelerinde (180, 300, 450 Watt) mikrodalga fırında kurutmanın Antalya koşullarında yetiştirilen ve hasat edilen hibiskus çanak yapraklarının kuruma karakteristikleri ve bazı fizikokimyasal özellikleri üzerine etkisi araştırılmıştır. Örneklerin kurutma karakteristiğinin değerlendirilmesinde on üç farklı model kullanılmıştır. Hibiskus çanak yapraklarının kurutma verilerine en iyi uyumu sağlayan model Midilli vd. (R2 ≥ 0.9983; χ2 ≤ 0.5156; RMSE ≤ 0.0193) olmuştur. Mikrodalga fırında gerçekleştirilen kurutma işleminin fırında gerçekleştirilen kurutma işlemine göre kurutma süresini yaklaşık 10 kat kısalttığı belirlenmiştir. Ayrıca kurutulan örneklerin pH, iletkenlik, renk, bulanıklık, antosiyanin ve fenolik madde içeriği gibi kalite özelliklerinde de önemli farklılıklar gözlenmemiştir.
Crafting Curses in Classical Athens
Authors: Lamont Jessica
Published: April 2021

This article presents a remarkable cache of five Attic curse tablets, four of which are published here for the first time. Excavated in situ in a pyre-grave outside the Athenian Long Walls, the texts employ very similar versions of a single binding curse. After situating the cache in its archaeological context, all texts are edited with a full epigraphic commentary. A discussion then follows, in which the most striking features of the texts are highlighted: in addition to the peculiar “first four-year period” (πρώτη πενθετηρίς) that the curses were meant to outlast, and the unparalleled term κυνωτόν, these texts are unusual in that they preserve over a full line of dactylic hexameter. The metrical formulae, combined with the presence of deictic language, may suggest that parts of the archetype curse underpinning these texts once circulated orally, in performative ritual contexts. The cache affords a singular glimpse into the process of curse-creation around 400 BCE, especially the ways in which a curse-writer could customize a fixed template spell to suit a client’s needs and circumstances. These tablets illuminate the shadowy process behind the creation of Athenian curse tablets, and the growing traffic in “magic” by the end of the fifth century BCE.
Effective communication in the nurse-patient relationship in the light of Transcultural Interprofessional Practice model
Authors: Lacerda Josefa Fernanda Evangelista de , Santos Paula Suene Pereira dos , Maia Evanira Rodrigues , Oliveira Dayanne Rakelly de , Viana Maria Corina Amaral , Cavalcante Edilma Gomes Rocha
Published: April 2021

Objective: to analyze the use of elements of effective nurse-patient communication in the light of the Transcultural Interprofessional Practice model. Methods: an integrative literature review was carried out in the CINAHL, LILACS, MEDLINE, SCOPUS, and Web of Science databases, without a time limit. Results: 12 studies were analyzed, most of them published in the English language, in 2017. Two categories were elaborated: effective verbal and non-verbal communication between nurses and patients. The elements of effective verbal communication were presented as speech and language; non-verbal ones presented as signals, distance, eye contact, time, touch, listening, empathy, and patience. Technology-assisted communication was part of both. Less frequently, the verbal communication process was hindered by language and non-verbal communication due to a lack of time availability. Conclusion: effective communication favors the establishment of trust, interaction, and the nurse-patient relationship.
The experience of patients undergoing liver transplantation in the transition of care
Authors: Knhis Neide da Silva , Wachholz Laísa Fischer , Sens Suyan , Amante Lúcia Nazareth , Mendes Karina Dal Sasso
Published: April 2021

Objective: to understand the experience of patients undergoing liver transplantation in the transition of care between hospital and home. Methods: study with a qualitative approach, with 20 patients undergoing liver transplantation who were interviewed using a semi-structured script. Content analysis was the selected technique to identify aspects inherent to the transition of care. Results: based on the data obtained, four thematic categories were formed: Path marked by feelings and uncertainties; Path of comings and goings to the health network to acquire supplies; Learning path to develop home care and: Itinerary between social idealization and the reality experienced after transplantation. Conclusion: difficulties of recipients and family after liver transplantation were perceived, especially in the preparation for the transition of care and in coping and adapting to daily activities.
Decision making for nursing rehabilitation in intensive care: foci of care
Authors: Prazeres Virgínia Maria Pereira , Ribeiro Catarina Dias , Marques Goreti Filipa Santos
Published: April 2021

Objective: to understand the focus of care developed by nurses specialized in adult intensive care rehabilitation. Methods: qualitative study with a focus group session with six nurses, specialists in rehabilitation nursing, who have roles in the intensive care of three hospitals. The information transcribed was submitted to content analysis. Results: regarding the profile of participants, three were female and three were male, with ages varying from 28 to 51 years old, with a mean of 39.33 years old (standard deviation=7.32). Through data analysis, two categories emerged: Sedated Clients and Awake Clients. Conclusion: when the client was sedated, the care was focused on the processes of the respiratory and musculoskeletal systems that were compromised. When he was awake, more elements related to those body processes became foci of care, in addition to other elements related to the psychological process, to the phenomenon of status, and to self-care.
Obesity, COVID-19 and vitamin D: is there an association worth examining?
Authors: Marks Ray
Published: April 2021

Many COVID-19 deaths among those enumerated in the context of the 2020 corona virus pandemic appear to be associated more often than not with obesity. At the same time, obesity has been linked to a deficiency in vitamin D, a factor that appears to hold some promise for advancing our ability to intervene in reducing COVID-19 severity. This mini-review reports on what the key literature is reporting in this regard, and offers some comments for clinicians and researchers. Drawn from PUBMED, data show that a positive impact on both obesity rates and COVID-19 morbidity and mortality rates may be attained by efforts to promote vitamin D sufficiency in vulnerable groups
Risk factors associated with overweight and obesity among reproductive aged females residing in Bharatpur Metropolitan City
Authors: Subedi Sadikshya , Bhattarai Richa , Bista Rojina
Published: April 2021

Overweight and obesity is becoming one of the major public health problems in developing countries like Nepal. A cross sectional study was conducted to assess the risk factors associated with overweight and obesity among reproductive aged females of 15-49 years residing in Bharatpur metropolitan city. Anthropometric measurement was used to determine Body Mass Index (BMI), Waist Circumference (WC) and Waist Hip Ratio (WHR). Data on socio-demographic, physical activity, dietary and behavioral factors was collected using structured questionnaire. Microsoft excel and SPSS version 20 were used to analyze data and chi square test was performed to analyze the factors associated with BMI, WC and WHR cut-offs. The result of this study revealed that 32.3% of females were overweight and 9.7% of females were obese. Similarly, on the basis of waist circumference 69% of females were abdominally obese and on the basis of waist hip ratio 68% of females were abdominally obese. Mean BMI was found to be 24.1c10.01 kg/m2, waist circumference was found to be 86.41±13.091 cm and waist hip ratio was found to be 0.89±0.108. This study shows that age, marital status, parity, stress, sleeping time, calorie intake, carbohydrate intake, physical activity and fruits consumption were found to be significantly associated (P<0.05) with overweight and obesity. Age, marital status, parity, calorie intake, fat intake, physical activity and fruits consumption were found to have significant association (P<0.05) with waist circumference. Similarly, age, marital status, parity, cloth wear, calorie intake, carbohydrate intake and physical activity were found to be significant predictors (P<0.05) of WHR in the study. The findings show a clear evidence of the rising trends of overweight and obesity among reproductive aged female. Overall this study indicate that efforts should be made to address the problem of overweight and obesity, by addressing the factors associated and minimize its consequences
The use of apple cider vinegar as a secondary treatment line with conventional diabetic treatment as a new medical hypothesis linking type 1 diabetes and type 2 diabetes
Authors: Alkhatib Ahed J
Published: April 2021

The diabetes as a disease has been reported for 3500 years. Although diagnostic and therapeutic approaches have continuously developed, no definitive therapeutic approaches have so far been reached. Diabetes is not a single disease; it interferes with various systems in the body including nervous system and cardiovascular system. The therapeutic lines for type 1 diabetes start with insulin and will need another treatment such as metformin. On the other hand, type 2 diabetes treatment strategies start with metformin and there will be a need for another treatment, insulin according to the disease progression. At certain point, both types of diabetes are treated applying the same strategies. In this study, we followed another strategy by applying the use of apple cider vinegar in patient with type 1 diabetes, and patient with type 2 diabetes following getting each meal. The results showed that glucose levels were within reference range after five days. Taken together, the use of apple cider vinegar as a secondary treatment line with conventional diabetic treatment is promising and needs to be further investigated
Detection of plasminogen activator inhibitor-1 (-675 4G/5G) gene polymorphism in women with recurrent abortion
Authors: Shaala Iglal Youssef , Moneim Deghady Akram Abdel , Haleem Abo Elwafa  Reham Abdel , Hosny Tamer Ahmed , Ammar Engy Taher
Published: April 2021

Background: recurrent abortion is considered one of the most common complications that occur during pregnancy and counts for 15% of pregnancies that are recognized clinically. Many causes can be attributed to the recurrent pregnancy loss e.g. chromosomal anomalies, thrombophilic disorders, uterine anomalies, endocrine abnormalities and fetal anomalies. Thrombophilia can be either hereditary or acquired. Multiple genes had been implicated in the pathogenesis of the thrombophilia. Previous studies have indicated that genetic polymorphism of the plasminogen activator inhibitor-1 gene (PAI-1) may be associated with recurrent abortion. Aim: The aim of the present study was to investigate whether plasminogen activator inhibitor-1 (-675 4G/5G) gene polymorphism is associated with the occurrence of recurrent pregnancy loss or not. Methods: DNA samples were collected from sixty six female patients with recurrent abortion (33 primary abortion, 33 secondary abortion) and thirty four healthy controls with normal pregnancy for detection of plasminogen activator inhibitor-1 (-675 4G/5G) gene polymorphism by restriction fragment length polymorphism PCR. Results: there was a significant association between PAI-1(-675 4G/5G) polymorphism and the occurrence of recurrent pregnancy loss. Conclusion: Our results assumed that PAI-1 (-675 4G/5G) polymorphism is associated with recurrent pregnancy loss.
Aspects of interest related to antiemesis in haematological patients
Authors: Fernandez Gonzalez Maria Perfecta , Gomez Marquez Aurea Maria , Sanchez Maria Pereiro , Iglesias Varela Raquel , Sastre Moral  Jose Luis , Redondo Carlos Ulibarrena
Published: April 2021

Few side effects of cancer treatment are more fearsome for patients than nausea and vomiting. Although both can result from surgery or radiation therapy, chemotherapy-induced nausea and vomiting (CINV) are potentially the most severe and the most distressing ones. Despite recent advances in the prevention of emesis induced by chemotherapy, its control remains to be insufficient in 20-25%.1s of patients, with the ensuing negative impact on their quality of life. In this small review, we intend to analyze some critical aspects related to the approach of antiemetic therapy in the clinical practice in haematological patients.
Autism spectrum disorder: impact of diagnosis on children’s parents
Authors: Martins Rosa , Carvalho Nélia , Carvalho Ruben , Batista Susana
Published: April 2021

Objectives: To evaluate the impact of the diagnosis of autism in parents and to analyze its determinants. Methodology: Descriptive and correlational study. Used a sample of 138 parents enrolled in three Portuguese Association for Developmental Autism Disorders. The questionnaire included sociodemographic issues and a scale for assessing the impact of parenting. Results: The impact of the diagnosis on the parents was moderate, but they are concerned about the future of their children, with the reactions and attitudes of the current society and lack of support / felt needs. Conclusions: this study point to the promotion of intervention strategies by health professionals in order to minimize the negative impact that this diagnosis causes in families.
Leprosy: a mimicking disease that clinicians should keep in mind
Authors: Tadeu Villa Ricardo
Published: April 2021

A long history of more than a decade of misdiagnosis is presented. Mention is made of immunosuppressive treatments and their frustrating results until the clinical suspicion of leprosy has led to further investigation and follow-up with home visits with the appropriate therapeutic approach and cure.
Mitochondrial encephalopathy with stroke-like episodes and lactate acidosis (MELAS syndrome): diagnostic criteria, features of epileptic seizures and treatment approaches
Authors: MA Yamin , OV Belyaev , LV Araslanova
Published: April 2021

The paper describes a patient with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes syndrome (MELAS). The features of the course and therapy of epilepsy in MELAS are discussed. The disease is known for its late diagnosis when years elapse from the onset of the clinical manifestations to diagnosis. The paper presents clinical criteria for the diagnosis of MELAS and the specific features of brain neuroimaging changes that allow identification of the disease at an early stage.
Twist drill aspiration of chronic subdural hematoma at the Ignace Deen hospital of Conakry
Authors: Bah Alpha Boubacar , Diawara Seylan , Souare Ibrahima Sory , Barry Abdoulaye , Donzo Ansoumane , Denamou Joseph , Bobo Diallo Abdoulaye
Published: April 2021

Bedside percutaneous twist drill aspiration (TDA) is described as a surgical method of management of Chronic subdural hematoma (CSDH) and appear to be a reasonable approach in low medical resources environment. We report the results of TDA of CSDH in a single tertiary centre in Conakry Republic of Guinea in West Africa, for the period March 2015 to October 2017. The charts and medical record of 38 cases of CSDH treated with TDA were collected retrospectively, with a mean follow-up of 84.2 days. The outcome data assessed were neurologic status evaluated by the follow-up Markwalder grading scale (MGS: 0=normal to 4=coma), recurrence, infection and mortality. The Male-Female ratio was 1.3:1. Mean age at diagnosis was 78.2+/-12 years. Traumatic brain injury (TBI) was identified as causal in 28.2% of cases studied. All patients were operated on under local anesthesia and had a postoperative drain left in place for 3 days. The mean postoperative MGS was 1.06, up from a mean preoperative MGS of 3.7. Two cases of recurrence occurred subsequent to TDA causing death and three other patients died from unknown causes during the follow-up period. No cases of post-operative infection were diagnosed during the follow-up. Our study shows that Bedside TDA appears to be a suitable alternative to burr hole craniotomies in urgent cases of CSDH in the low socio-economic setting, where a surgical theatre is not always available.
NRAS Q61R-mutant mucosal melanoma with cardiac metastasis - a diagnostic challenge
Authors: Dima Danai
Published: April 2021

We present this case report of a patient with NRAS Q61R-mutant melanoma, suspected to be mucosal melanoma of small bowel origin with cardiac, hepatic and pulmonary metastases. We focus on the unique manner of diagnosis (requiring the finding of a specific molecular signature via liquid biopsy in conjunction with tissue biopsy) and management of this rare cancer with first-line immunotherapy with dual checkpoint blockade followed by maintenance PD-1 inhibition, allowing the patient to have sustained clinical response at eight months since original diagnosis.
Family Policy in Big Cities in Terms of Demographic Transition
Authors: KRIMER B. О.
Published: April 2021

The paper considers the development of family policy in metropolises within the frameworks of the second demographic transition. Demographic transformations lead to the spread of vulnerability of certain categories of families with children—single-parent families, large families—as well as exacerbation of the problem of combining childbirth and employment, aff ordability, favorable environment for childbirth. The aim of the work is to analyze the peculiarities of fertility transformations in metropolitan cities of Ukraine and to identify the challenges caused by them, to consider current practices of family policy in developed European countries, to formulate conclusions on the development of family policy in Ukrainian cities. The work uses an array of statistical indicators, formed on the basis of the State Statistics Service of Ukraine, the Organization for Economic Cooperation and Development (OECD Family Database), Eurostat (Eurostat). Fertility trends in metropolitan cities are studied by analyzing long time series. Correlation analysis is used to determine the importance of individual fertility factors in modern Ukraine. The study of family policy and the formation of recommendations is carried out using a historical analogy and a systematic approach. The novelty of the article lies in the confi rmation of the conformity of the transformation of fer tility in metropolises of Ukraine to European processes and formation of a vision of fami ly policy development in large metropolitan cities of Ukraine based on the study of demographic challenges and experience of family policy in Europe. In large metropolitan cities, the aging of motherhood and the spread of vulnerability of certain categories of families with children—single-parent families, large families—as well as exacerbation of the problem of combining childbirth and employment, aff ordability, favorable environment for childbirth has grown in intensity. Priority areas for the development of family policy in a metropolitan are the development of child care services, promotion of parental employment, promotion of housing, spread of gender equality.
Social Potential of Non-Profi t Organizations
Authors: NOVIKOV V. M.
Published: April 2021

There is a steady trend in the wide range of literature on the study of institutions: the definition of theoretical judgments often does not coincide and is not combined with the definition of general connections and patterns, which leads to ignoring the principle of systematic analysis of socio-economic processes. Indirectly, this means the priority of the random (individual) over the whole and general. Meanwhile, the concept of an institution correlates with the specific content of a phenomenon or process and is supplemented by a generalized and systematic approach. The study of such an urgent problem of the market economy as institutional choice through non-profit organizations requires the extension of the analysis not only to governmental but also to non-governmental structures, which are an element of the whole. In this regard, the article provides a historical overview of the development of nonprofit organizations and charitable activities as a large-scale social phenomenon, which made it possible to draw attention to the possibility of using the experience of past years for the purposeful organization of non-state institutions of charity, including by improving social partnerships. Analysis of the current state of non-profit organizations in Ukraine, despite the growth in their number, shows a decrease in the volume of charitable activities. In recent years, the country has taken certain steps to improve charity. However, this is not enough. The institutional environment for philanthropy needs to be improved. The solution to this problem is possible with the active influence of the state on the management of non-commercial activities. Improving the tools of functioning, financing, as well as increasing attention to the development of statistics in this area of activity is considered relevant. In this regard, the purpose of the article is to identify pressing issues and ways to improve charitable organizations. The solution to this problem is possible with the active influence of the state on the management of non-profit activities. The development of the institutional framework of the nonprofit sector of the economy means the improvement of financial reporting, greater openness of charitable organizations, streamlining of their legal relations, liberalized taxation and strengthened control over the activities of non-profit organizations. The article pays special attention to the problem of accumulation and distribution of charitable funds. The potential of charitable organizations can be expanded by shifting the focus of their regulation away from predominantly corporate to regional administration, which increases the importance of the institution of partnership in the development of charity. The article uses historical and logical methods, which allowed to study the formation and development of non-profit organizations in the evolutionary aspect.
Життя і творчість С. М. Реріха та його зустрічі з конструкторами КБ «Південне» в Індії за програмою «Інтеркосмос»
Authors: Чистякова Е. П. , Губка О. О.
Published: April 2021

Висвітлено основні віхи життєвого і творчого шляху видатного художника, мислителя і громадського діяча С. М. Реріха. Розказано також про радянсько-індійську співпрацю за програмою «Інтеркосмос» і про зустрічі конструкторів і вчених КБ «Південне» (м. Дніпропетровськ, нині – Дніпро) зі Святославом Реріхом у рамках цієї співпраці. Значущими для авторів стали відомості, отримані за допомогою методу інтерв'ю. За його допомогою вдалося зібрати цікаву і рідкісну інформацію у конструкторів космічних апаратів з КБ «Південне», а також отримати їх спогади про зустрічі зі Святославом Миколайовичем у маєтку Татагуні під містом Бангалором у 70-х роках XX століття. Саме в Бангалорі здійснювалося співробітництво радянської та індійської сторін, у результаті якого з'явилися перші індійські супутники «Аріабхата» та «Бхаскара», а успішний запуск цих супутників сприяв створенню і становленню національної космічної програми Індії
Power Distance as a Variable in Assessing Employees' Behavior towards Information Security Policy Compliance in a High-Power Distance Society: An Exploratory Study
Authors: Etim Erasmus , Streff Kevin , Park Insu , Rowland Pam
Published: April 2021

Information security is a concern of every business, therefore the need for employees to comply with a policy that would protect the organization's assets.  The model developed for this research was based on Protection Motivation Theory, Theory of Planned Behavior, and Rational Choice Theory.  There were 129 responses from Nigeria used to validate the model.  The data analysis using PLS-SEM resulted in these findings: self-efficacy, normative beliefs, and power distance were significant, therefore impacting.  Therefore, not significant descriptive norms did not positively impact intention to comply with information security policy.  Power distance was impactful on employees' intention to comply with information system policy and contributed to theory and practice; respondents chose to do right by their intention to comply with information security policy.  Training and managerial oversight in policy compliance are significant since those actions would help protect the organization's information.  The analysis showed the adverse effect of a high correlation between indicators of different constructs.
Blind spot in sepsis management – Tissue level changes in microcirculation
Authors: Xantus G. , Allen P. , Kanizsai P.
Published: April 2021

In sepsis cytokine-mediated inflammation, clotting cascade activation and glycocalyx shedding impair both function and structure of the microcirculation, compromising adequate tissue oxygenation/perfusion. Such mismatch results in “dysoxia”, an imbalance in mitochondrial respiration.

Microvessel injuries can be grouped into four types: cytotoxic oedema, micro-vessel heterogeneity, sluggish/absent flow, and focal anaemia. Recognition of such diversity in microcirculatory pathology, alongside with the implementation of novel biomarkers might reveal previously unobserved heterogeneity in adults diagnosed with sepsis. Early identification of distinct subtypes may help not only to better stratify disease severity but may also provide explanation to the often seen insufficient/absent response to resuscitative treatment. Experimental evidence suggests that impaired microcirculatory flow may correlate with organ dysfunction and mortality. Therefore, reliable/reproducible diagnostic tools, that provide real-time information about the dynamic state of the microcirculation, might be practice changers in managing the critically ill.

The sublingual mucosa and the nailfolds provide easy access to microcirculation via hand-held, point-of-care devices. Accessing these windows, clinicians may recognise, understand and potentially correct the underlying tissue oxygenation/perfusion mismatch. This new clinical information might facilitate an individualised approach vs protocolised care aiming to administer the right balance of intravenous fluids/vasopressors, time/dose auxiliary treatment modalities and, most importantly, might also guide determining the optimal duration of resuscitation to avoid/minimise harm and maximise benefits in sepsis management. However, before every-day clinical use of such point-of-care microcameras, validation studies are needed to establish not only feasibility but reliability and reproducibility as well.
The effect of winter swimming on body's external temperature
Authors: Bach Anna M. , Dziarkowski Dariusz , Gawrych Szymon , Yermakova Tetiana
Published: April 2021

Background and Study Aim. The main aim was to compare the changes in external body temperature of students who gave in an immersion of winter swimming.

Material and Methods. The study group consisted of 15 students, including 7 males and 8 females. The average age of the subjects was 22.4+1.12 years. The group was tested by measuring outer body temperature at 30 spots across their bodies by using a FLUXE 64 MAX pyrometer. Afterwards, subjects entered ice-cold water for 3 minutes. Immediately after leaving the water the second temperature measurements at the same 30 spots were conducted, and the third measurements were done 15 minutes after leaving the water. After 15 days of testing the comparison was made: temperature values from before and after the immersion.

Results. The students showed significantly higher average body temperature values before the testing (34.96°C ± 2.21 to 21.85 ± 3.68) and the lowest after the testing (29.86°C ± 4.91 to 6.26°C ± 1.04). The highest difference in average temperatures was obtained in the measurement of the left lower leg - front, the examination before and after (20.73°C), and the lowest in the measurement of the right hand - palm side, the examination after and 15 minutes after (0.19°C).

Conclusions. Winter swimming is becoming an increasingly popular sport activity. Conducted research shows the positive influence of winter swimming on human body and organism. The presented research should be further continued in order to learn more about the influence of cold on human body.
Interpretation of the generalized parameter of the probability of failure through the plastic stress intensity factor
Authors: Tumanov A. V , Boychenko N. V
Published: April 2021

The main purpose of this work is to statistically analyze the fracture toughness of compact specimens made of S55C steel in terms of elastic and plastic stress intensity factors. The fracture toughness tests results at three-point bending were used for a comparative statistical analysis of the fracture parameters. Five type of specimen configuration with various thicknesses were tested at a constant ratio between crack length and specimen width. The critical loads were obtained as a tests result for various combinations of crack length and specimen thickness. In addition, uniaxial tensile tests were carried out to determine the main mechanical properties of the material. Obtained material properties were used in numerical calculations. Numerical calculations were carried out to determine the elastic and plastic stress intensity factors. Three-dimensional finite element analysis was performed on the basis of the experimental data on curvilinear crack front positions in tested specimens. The crack tip stress-strain fields were obtained for each of the tested samples as a result of numerical calculations. These fields were used to calculate the values of the plastic intensity factors along the curvilinear crack fronts. A statistical analysis of the fracture toughness of compact specimens made of S55C steel was carried out based on the obtained critical values of elastic and plastic stress intensity factors. The advantages of using the plastic stress intensity factor as a generalized parameter for the fracture probability are demonstrated. In addition, the sensitivity of the plastic stress intensity factor to constraint effects avoids the introduction of additional parameters into the statistical models.
Автоматичне керування процесом сушіння плодоовочевої сировини в конденсаційній термоелектричній сушарці
Authors: Якубаш І. В.
Published: April 2021

Сушіння є одним з найбільш ефективних методів збереження сільськогосподарських і харчових продуктів. Якість висушеного продукту залежить від дотримання регламенту технологічного процесу сушіння. Підвищення якості ведення технологічного процесу (ТП) сушіння плодоовочевої сировини впливає на якість виготовленої продукції, що, в свою чергу, призводить до підвищення конкурентоспроможності підприємства. Дотримання регламенту ТП можливе лише за його автоматизації. Тому завдання автоматизації ТП дедалі більше постає перед сучасними підприємствами. Огляд існуючих вітчизняних розробок в сфері  автоматизації сушіння, зокрема сушіння плодоовочевої сировини, показує наявність суттєвих недоліків. В ОНАХТ, на кафедрі АТП і РС у рамках випускної роботи бакалавра розроблено новий підхід до автоматизації керування конденсаційною сушаркою, задля забезпечення високоефективного сушіння плодоовочевої сировини. Метою роботи є розробка найдосконалішої математичної моделі, функція якої б полягала в відтворенні основних властивостей середовища сушіння сільськогосподарських та харчових продуктів, з можливістю їхнього відображення та дослідження. В роботі розкрито мету ТП сушіння та виділено основні технологічні параметри, для яких необхідно скласти регламент, для забезпечення високої якості готової продукції. Складено структурну схему моделі об’єкта керування. Проведено аналіз його каналів зв’язку та їх ідентифікацію. Канали математично описано статичними аперіодичними ланками другого порядку. Розроблено модель id-діаграми вологого повітря, яка є достовірною. Також розроблено повну математичну модель об’єкту керування і зроблено висновки про можливість її використання у подальших розробках як основу при синтезі моделі системи автоматичного регулювання. На кафедрі АТП і РС було реалізовано фізичну модель, яка працює з відповідними встановленими параметрами та відповідає всім перехідним процесам.
Огляд системи регулювання рівня води парогенератора блоку ВВЕР-1000
Authors: Яроцький М. М.
Published: April 2021

Досліджені властивості парогенератора блоку ВВЕР-1000, виведені основні характеристики об’єкта і вказані основні принципи, які допоможуть застерегти від помилок  у вивченні даного питання. Представлені види автоматичних систем регулювання та вивчені основні недоліки кожної з систем регулювання. На основі зробленого аналізу було встановлено, яка саме автоматична система регулювання є найбільш краща для парогенератора. Пояснений процес знаходження параметрів регулятора та коефіцієнтів пристроїв зв'язку для каналу витрати пари, витрати живильної води та рівня води в парогенераторі. В більшості публікацій не робиться пояснень, чому використовується 3-х імпульсна автоматична система керування, не виконується порівняння з іншими системами регулювання, і просто приводиться вже як факт що використовується 3-хімпульсна система регулювання без пояснень та тонкощів налаштування самої системи регулювання. Не робляться пояснення стосовно налаштування регулятора для 3-х імпульсної автоматичної системи регулювання і для чого потрібні коефіцієнти пристроїв зв'язку. Тому в статті зроблено пояснення, чому використовується 3-х імпульсна автоматична сиситема регулювання а не 2-х імпульсна, як правильно налаштувати регулятор рівня води та як налаштувати пристрої зв'язку і для чого вони потрібні. Приведена модель парогенератора в середовищі Simulink та показано яким чином проходить налаштування спочатку пристроїв зв'язку і потім знаходження параметрів для ПІ-регулятора. Зроблені висновки стосовно застосування 3-х імпульсної системи регулювання, яку модернізацію вона отримала на виробництві та доцільність її використання.
Числовий метод обчислення критичного навантаження на долото при бурінні свердловин
Authors: Горбійчук М. І. , Кропивницький Д. Р.
Published: April 2021

В роботі розглядається вплив осьового навантаження на долото на форму бурової колони. Визначено, що збільшення даного параметру до критичного значення приведе до деформації бурової колони, що в свою чергу може спричинити аварійну ситуацію. Для визначення критичного значення осьового навантаження було побудовано багатокутник сил, що діють на нижньому кінці бурильної колони, що визначається координатою , що є точrою максимального прогину бурильної колони, та побудовано математичні залежності у вигляді системи диференціальних рівнянь (форма Коші). В середовищі MatLab було розроблено алгоритм визначення заданої координати x, який включає в себе розв’язок системи диференціальних рівнянь методом Рунге-Кутта та побудову інтерполяційного поліному Лагранжа. Побудовано графічні залежності зміни прогину бурильної колони при різних значеннях згинаючого моменту.
За результатами обчислень синтезовано емпіричні моделі визначення точки максимального прогину бурильної колони у вигляді полінома 2-го порядку, параметри яких обчислено за методом найменших квадратів. Адекватність моделей перевірено за допомогою коефіцієнта кореляції. Обчислені значення коефіцієнта кореляції є близькими до одиниці, тому можна стверджувати, що запропонована емпірична модель адекватно описує «експериментальні» дані.
Було проведено серію машинних експериментів при різних значеннях максимальної степені полінома і визначено, що при степені полінома рівній 3, емпірична модель, яка є функцією f(a, x) з високою точністю описує результати даних.
Автоматизація пастеризації яблучного соку
Authors: Бричук Б. В.
Published: April 2021

Здоров'я - безцінне надбання не тільки кожної людини, але і всього суспільства. Для підтримки здоров`я людини на певному рівні, необхідно включати в раціон харчування фруктові та овочеві соки, зокрема яблучний сок, який має високі споживні властивості. Збереження цих властивостей можна забезпечити лише за рахунок автоматичного керування технологічним процесом виробництва яблучного соку. Автоматичне керування процесом пастеризації яблучного соку – одне з найбільш складних та важливих  завдань, оскільки забезпечує дотримання технологічного регламенту термічної обробки яблучного соку. Процес пастеризації яблучного соку, як об'єкт керування являє собою складну динамічну систему. Аналіз існуючих систем автоматичного керування пастеризацією яблучного соку демонструє певні недоліки і ставить задачі наступної розробки. В Одеській національній академії харчових технологій, на кафедрі автоматизація технологічних процесів і робототехнічних систем розроблено новий спосіб пастеризації яблучного соку, з використанням каскадної системи автоматичного регулювання, яка зменшує запізнення в контурі регулювання  температури пастеризації,  що підвищує якість готового продукту, продуктивність процесу та знижує його енергоємність. Результати структурно-параметричного синтезу і аналізу розробленої системи автоматичного керування підтверджують переваги запропонованого підходу. Побудована каскадна система автоматичного регулювання забезпечує високу динамічну точність керування розглянутим технологічним процесом. Розроблене автоматизоване робоче місце оператора-технолога і наладчика системи автоматичного керування в SCADA-системі дозволяє зручно і ефективно спостерігати та керувати ходом процесу пастеризації яблучного соку. Подальший розвиток питання автоматизації керування процесом пастеризації яблучного соку знайде в магістерській випускній роботі.
Виробничий потенціал молокопереробних підприємств України у контексті євроінтеграційного розвитку
Authors: Крюкова І. О.
Published: April 2021

У статті проведено аналіз виробничого потенціалу молокопереробних підприємств України,досліджено сучасний стан сировинної бази молокопродуктової галузі в контексті забезпечення внутрі-шніх потреб та окремих індикаторів продовольчої безпеки населення країни. Проаналізовано обсяг іструктуру споживання молокопродуктів в Україні у порівнянні з країнами ЄС. Дана оцінка розвитку на-ціонального ринку молока і молокопродуктів в порівнянні з ключовими тенденціями європейського ри-нку. Проаналізовано особливості товарної структури молочної галузі України та європейських країн.Досліджено потенціал використання європейських квот на вітчизняну молокопродукцію, основні на-прями та прогнози експорту молокопродуктів у країнах ЄС, виявлено відмінності між обсягами держа-вної фінансової підтримки молочної галузі європейських країн та України. Результатами дослідженнястало обґрунтування перспективних шляхів подальшого розвитку галузі та напрямів диференціаціїгеографічної структури експорту для вітчизняних молокопереробних підприємств.
Aspects of financial analysis of the company's equity in modern conditions
Authors: Kuprina N. , Markova T. , Velychko O.
Published: April 2021

The purpose of the research is to analyze the scientific works on the o study approaches to conducting financial analysis of industrial equity of enterprises in the theoretical and practical aspect, justification ofthe need to formulate a comprehensive approach for such aanalysis of the equity of the enterprise in themanagement system.The analysis of the works of scientists showed that when conducting a financial analysis of an enterprise's equity, it is mainly conducted in the context of the analysis of the financial condition of the enterprise,both in the overall assessment and in absolute and relative terms, which is not complete in the current conditions of managing the enterprise resources and sources of their formation.The scientific result of the research is the formation of a comprehensive approach to the financialanalysis of the equity of an industrial enterprise, which is relevant in the current market conditions of operation of enterprises and covers the analysis of its dynamics, structure, turnover, profitability, risk and its protection. The practical importance of this work is directed to the use of this method of equity analysis as a toolof financial analysis in the modern conditions of management of industrial enterprises to ensure the efficiency of their activities and management.
Діагностика екологічної ємності національної економіки у секторальному вимірі
Authors: Нікішина О. В.
Published: April 2021

Стаття присвячена обґрунтуванню методичного забезпечення діагностики екологічної ємності(відходо- та вуглецевоємності) національної економіки у секторальному вимірі на засадах сталого роз-витку. Наголошено, що даний методичний базис є складовою загальної методології діагностики домі-нант інвестиційно-інноваційної політики природокористування національної економіки. Запропонованосистему індикаторів для діагностики екологічної ємності крізь призму Цілей і завдань сталого розвиткудержави з акцентом на секторальний та інвестиційний вимір. На основі авторських методичних поло-жень проведено кількісну та експертну оцінку відходо- та вуглецевоємності економіки України, що до-зволило встановити сучасні тенденції та проблеми зниження екодеструктивного впливу секторів на при-родне середовище. Проведено порівняльний аналіз відходоємності валової доданої вартості різних сек-торів економіки, встановлено взаємовплив інвестиційного потенціалу на динаміку показників екоємностінаціональної економіки. На підставі результатів діагностики обґрунтовано головні напрями і шляхи зме-ншення екологічної ємності вітчизняної економіки в координатах сталого розвитку.