bluuebunny/crossref_metadata_2025 huggingface dataset:
A Modern Approach to the Diagnosis and Management of Systemic Lupus Erythematosus
Authors:   V.A. Nasonova Scientific and Research Institute of Rheumatology, Panafidina T.A. ,   Moscow, Russian Federation, Popkova T.V. ,   V.A. Nasonova Scientific and Research Institute of Rheumatology; Moscow, Russian Federation, Aseeva E.A. ,   V.A. Nasonova Scientific and Research Institute of Rheumatology; Moscow, Russian Federation, Lila A.M. ,   V.A. Nasonova Scientific and Research Institute of Rheumatology; Moscow, Russian Federation,   Russian Medical Academy of Continuous Professional Education at the Ministry of Health of the Russian Federation; Moscow, Russian Federation
Published: October 2021

Objective: Using available information on epidemiology, to analyse the impact from genetic factors and environment on development of systemic lupus erythematosus (SLE); to discuss asymptomatic and clinical periods of the disease; to assess the intensity of the disease, organ damages, comorbidities; to discuss the ways to improve SLE diagnosis and management. Key Points. The number of SLE cases has grown recently. The magnitude of clinical manifestations, cycles with remissions and aggravation make this disease one of the most difficult to diagnose, manage and assess therapy efficiency. As there are no diagnostic criteria for the disease, classification criteria are improved constantly. Despite the fact that the onset of the disease in half of patients is with low SLE intensity, later the disease progresses and affects several organs and systems. About 70% of patients failed to have a long-lasting remission; therefore, therapy protocols should be improved and should include immunosuppression and biological therapy. Conclusion. One of the burning issues in the modern rheumatology is lack of methods for early diagnosis and prognosis of the disease. Development and practical implementation of therapy recommendations can improve the therapy results and disease outcome. Keywords: systemic lupus erythematosus, epidemiology, criteria of the European League Against Rheumatism/American College of Radiology 2019, intensity, lupus nephritis.
Clinical and X-ray Manifestations of Mycobacteriosis in Patients with Chronic Lung Disease
Authors:   Central Scientific and Research Institute of Tuberculosis, Sargsyan A.P. ,   Moscow, Russian Federation, Makaryants N.N. ,   Central Scientific and Research Institute of Tuberculosis; Moscow, Russian Federation, Lepekha L.N. ,   Central Scientific and Research Institute of Tuberculosis; Moscow, Russian Federation, Chernousova L.N. ,   Central Scientific and Research Institute of Tuberculosis; Moscow, Russian Federation
Published: October 2021

Study Objective: to identify clinical and X-ray features of mycobacteriosis caused by slow-growing forms of nontuberculous mycobacteria (NTMB), in patients with chronic non-specific lung diseases and TB. Study Design: prospective and retrospective study. Materials and Methods. We examined 166 patients with chronic lung diseases: bronchitis, obstructive respiratory diseases, bronchiectatic disease, and TB. 79 patients had a primary disease and nontuberculous mycobacteriosis (NTM); controls were 87 patients without NTM. The study included only patients with slow-growing forms of NTMB. Study Results. Analysis of the clinical presentations demonstrated that, when associated with chronic lung diseases, a mycobacterial infection did not cause severe aggravation of clinical symptoms of the disease, except for TB. All study groups showed identical X-ray symptoms: fibrous, focal infiltrative, cavity changes, and bronchictasia. Still, most often they were recorded in patients with NTM. Conclusion. NTM caused by slow-growing forms of NTMB is diagnosed in long-lasting chronic non-specific lung diseases without aggravated clinical symptoms of the disease. When associated with the tuberculous process, a mycobacterial infection makes clinical symptoms more pronounced, but the duration of the disease remains the same. Excessive fibrosis is noted on CT scans, and main functional parameters get worse. Keywords: nontuberculous mycobacteriosis, chronic non-specific lung disease, TB.
Community-Acquired Pneumonia and Middle Lobe Abscess Associated with Chronic Obstructive Pulmonary Disease. A Case Study
Authors:   Volgograd State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health, Bashmakova O.P. ,   Volgograd, Russian Federation, Shilova L.N. ,   Volgograd State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; Volgograd, Russian Federation, Cherkesova E.G. ,   Volgograd State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; Volgograd, Russian Federation, Khortieva S.S. ,   Volgograd State Medical University (a Federal Government-funded Educational Institution of Higher Education), Russian Federation Ministry of Health; Volgograd, Russian Federation
Published: October 2021

Objective of the Paper: To demonstrate the issues with diagnosis and therapy in complicated community-acquired pneumonia associated with chronic obstructive pulmonary disease (COPD). Key Points. Community-acquired pneumonia is one of the most common diseases. Of special interest are patients with comorbidities, since they have more risk factors of poor prognosis. This article describes a clinical case of complicated community-acquired pneumonia associated with COPD. Despite an adequate therapy, the patient developed an acute middle lobe abscess requiring surgery, as the patient had confounding factors. Conclusion. Timely diagnosis and an early adequate therapy allow improving the condition and quality of life of the patient and preventing severe complications. Keywords: pneumonia, abscess, antibacterials, chronic obstructive pulmonary disease.
TARGETED REFINANCING OF BANKS AS A TOOL FOR ECONOMIC DEVELOPMENT
Authors: Oleh MAKAROV
Published: October 2021

Background. In order to stimulate lending, central banks use targeted refinancing operations, which allows lowering interest rates and increase the liquidity of the banking system. Taking the current state of bank lending in Ukraine, the development and implementation of effective lending stimulation program, namely targeted refinancing operations, is a crucial for further economic development. The aim of the article is to conduct a comparative analysis of lending programs in some developed countries, identify the shortcomings of the current lending stimulation program in Ukraine and develop a concept of a mechanism to stimulate lending by monetary policy measures in Ukraine. Materials and methods. The basis for the research is general and special scientific methods. Analysis, synthesis and systematization were used to assess targeted lending approaches in some countries, identification of shortcomings of the current lending stimulation program and further development of a concept for a targeted long-term refinancing mechanism in Ukraine. Methods of analytical and logical generalizations were also used for the research. Results. Targeted refinancing operations are widely used for lending stimulation in different countries. Depending on the final goals and the state of economy, these operations may differ in their conditions. Nonetheless, the most of the countries prefer monetary policy as a main driver for lending stimulation. In spite of that, currently in Ukraine the fiscal policy was selected as a driver for lending stimulation. The paper proposes to change this approach in view of its shortcomings and to use targeted refinancing of banks instead. Conclusion. The implementation of targeted refinancing in Ukraine will help to reduce the cost of lending and stimulate the development of prioritized sectors of the economy and decrease the dollarization of the economy. Considering the bearing risks, it is proposed to limit the total amount of targeted lending operations; limit the banks allowed to participate in targeted lending; extend the list of appropriate collateral against target refinancing.
German Colonial Rule in Present-day Namibia
Authors: Mielke Patrick
Published: October 2021

This article traces discursive shifts in the ways in which imperialism and European colonialism have been dealt with in the classroom in relation to the German history textbook Time for History (Zeit für Geschichte), which was published in 2010. It explores how the textbook’s representation of German colonial rule in present-day Namibia both raises awareness of and reproduces common colonialist-racist images of the “other” by demonstrating how its content is negotiated in year-nine history lessons, as observed over the course of an ethnographic study carried out in a German secondary school. The author assesses the complex interplay between discursive practices of negotiation, everyday educational practices and deeply rooted, colonialist-racist images of the “other” and, on the basis of this interplay, analyses how difficult it is to bring about content-based and discursive shifts in the classroom.
Architecture and planning factors of houses of culture in Novosibirsk
Authors: Makiyanskaya P. S. , Skudneva M. V.
Published: October 2021

The paper studies the problems of the modern architecture and planning of houses of culture intended for people of different age. The paper considers modern culture and leisure centers, analyzes the main approaches to the renovation of the architecture and planning structure of houses of culture, culture and leisure centers and cinemas, and highlights the design problems in the conditions of preserving the architectural and spatial environment.

The paper considers the main formative factors of the architecture and planning structure of houses of culture and analyzes the social functions of modern culture and leisure centers. The organization of leisure centers is connected with preservation of cultural and educational centers of the Soviet period, that do not meet the modern criteria (normative, architectural, artistic, planning and social). It is therefore necessary to create modern centers, in which the architecture and planning will satisfy a wide range of interests and creative opportunities of people.

The purpose of the paper is to study the architecture and planning factors of houses of culture in Novosibirsk for the creation of new multifunctional culture and leisure centers, taking into account the socio-cultural needs of people as well as modern trends in architecture.

The research methodology includes a comparison and systematization of the literature, Internet resources on the history of architecture of Novosibirsk, analysis of historical, economic, aesthetic and socio-cultural data relating to the formation of the architecture of cultural centers as well as culture and leisure time of people in the city of Novosibirsk.

Research implication include the factors influencing the formation of the architecture and planning structure of houses of culture such as functional-planning, landscape-visual, artisticaesthetic, socio-cultural, etc.

A study of the history of formation of houses of culture in Novosibirsk and the modern design experience show that these objects are multifunctional spaces created for active and enthusiastic people involved in various creative activities. Houses of culture are a place of inspiration, creative self-realization, intellectual and physical development, leisure, recreation and communication, a place where the ideas of a progressive society of the 21st century can be realized.
Riskante Retweets: „Predictive Risk Intelligence“ und Interessenvertretung in globalen Wertschöpfungsnetzwerken
Authors: Heimstädt Maximilian , Dobusch Leonhard
Published: October 2021

Soziale Medien spielen eine paradoxe Rolle für Interessenvertretung in globalen Wertschöpfungsnetzwerken. Zum einen bieten Social-Media-Plattformen Arbeitnehmer*innen und Gewerkschaften dieMöglichkeit der Mobilisierung über geografische und institutionelle Distanzen hinweg. Zum anderen lassen diese Plattformen aber auch zu, dass Dritte die digitalen Spuren dieser Kommunikation über Interessenvertretung (z. B. Tweets) extrahieren und verarbeiten. Ziel dieses Beitrages ist es, eine Form dieser Verarbeitung – „Predictive Risk Intelligence“ – als neuen Forschungsgegenstand einzuführen. Anbieter von Predictive Risk Intelligence erstellen, basierend auf Social-Media-Daten, Vorhersagen über Ereignisse wie Streiks und Proteste. Diese Vorhersagen stellen sie anderen Akteuren – beispielsweise Unternehmen – als Dienstleistung zur Verfügung. In diesem Beitrag nähern wir uns dem neuen Forschungsgegenstand über eine Fallstudie zu einem Anbieter dieser Dienstleistung. Ausgehend von der Fallstudie entwickeln wir eine Reihe an Forschungsfragen in Bezug auf etablierte und neue Akteure der Interessenvertretung in Wertschöpfungsnetzwerken. Abschließend diskutieren wir Lösungsansätze für methodische Herausforderungen des neuen Forschungsgegenstandes.
Homogenization of a stochastic model of a single phase flow in partially fissured media
Authors: Emereuwa Chigoziem , Mohammed Mogtaba
Published: October 2021

In this paper, we present new homogenization results of a stochastic model for flow of a single-phase fluid through a partially fissured porous medium. The model is a double-porosity model with two flow fields, one associated with the system of fissures and the other associated with the porous system. This model is mathematically described by a system of nonlinear stochastic partial differential equations defined on perforated domain. The main tools to derive the homogenized stochastic model are the Nguetseng’s two-scale convergence, tightness of constructed probability measures, Prokhorov and Skorokhod compactness process and Minty’s monotonicity method.
The sharp time decay rates and stability of large solutions to the two-dimensional Phan-Thien–Tanner system with magnetic field
Authors: Chen Yuhui , Li Minling , Yao Qinghe , Yao Zheng-an
Published: October 2021

In this paper, we consider the magnetohydrodynamic (MHD) flow of an incompressible Phan-Thien–Tanner (PTT) fluid in two space dimensions. We focus upon the sharp time decay rates (upper and lower bounds) and global-in-time stability of large strong solutions for the PTT system with magnetic field. Firstly, the convergence of large solutions to the equilibrium have been investigated and these convergence rates are shown to be sharp. We then show that two large solutions converge globally in time as long as two initial data are close to each other. One of the main objectives of this paper is to develop a way to capture [Formula: see text]-convergence result via auxiliary logarithmic time decay estimates with the initial data in [Formula: see text]. Improving time decay rates for the high-order derivatives of large solutions by using interpolation inequalities. In addition, time-weighted energy estimate, Fourier time-splitting method, semigroup method and iterative scheme have also been utilized.
Circulating CXCL13 could be serving as a biomarker for chronic lymphocytic leukemia severity
Authors: Aref Salah , Atia Doaa , Ramez Ahmed , Zeid Tarek Abou , Gouda Enas
Published: October 2021

BACKGROUND: Recent reports indicated the importance of chemotractant CXCL-13 in solid tumors and lymphoid malignancies. However, the prognostic value of the mentioned cytokines as biomarkers in chronic lymphocytic leukemia patient’s remains to be identified. Therefore; this study was designed in order to address the relation between CXCL-13 concentrations levels and markers of severity in CLL patients. METHODS: Our study included 150 CLL patients and 20 controls. Serum CXCL-13 was determined by ELISA for CLL patients at diagnosis as well as controls. RESULTS: The serum CXCL-13 levels were significantly higher in CLL patients as compared to controls. The high CXCL-13 concentration levels was significantly associated with high number of smudge cells; high LDH; high grade of Rai stage, short time to first treatment (TTT). Cox regression analysis was conducted for prediction of TTT, using age, gender, WBCs, smudge cells, CXCL-13, LDH, ZAP70, CD38, β2-microglobulin, Rai staging as covariates. High LDH, CXCL-13 and CD38% were significantly independent predictor for shorter TTT. CONCLUSION: High CXCL-13 serum levels at CLL diagnosis is correlated with other markers of disease activity; and could be served as biomarkers that predict CLL patient’s outcome.
A smarthome conversational agent performing implicit demand-response application planning
Authors: Alexiadis Anastasios , Veliskaki Angeliki , Nizamis Alexandros , Bintoudi Angelina D. , Zyglakis Lampros , Triantafyllidis Andreas , Koskinas Ioannis , Ioannidis Dimosthenis , Votis Konstantinos , Tzovaras Dimitrios
Published: October 2021

In recent years, the growing use of Intelligent Personal Agents in different human activities and in various domains led the corresponding research to focus on the design and development of agents that are not limited to interaction with humans and execution of simple tasks. The latest research efforts have introduced Intelligent Personal Agents that utilize Natural Language Understanding (NLU) modules and Machine Learning (ML) techniques in order to have complex dialogues with humans, execute complex plans of actions and effectively control smart devices. To this aim, this article introduces the second generation of the CERTH Intelligent Personal Agent (CIPA) which is based on the RASA framework and utilizes two machine learning models for NLU and dialogue flow classification. CIPA-Generation B provides a dialogue-story generator that is based on the idea of adjacency pairs and multiple intents, that are classifying complex sentences consisting of two users’ intents into two automatic operations. More importantly, the agent can form a plan of actions for implicit Demand-Response and execute it, based on the user’s request and by utilizing AI Planning methods. The introduced CIPA-Generation B has been deployed and tested in a real-world scenario at Centre’s of Research & Technology Hellas (CERTH) nZEB SmartHome in two different domains, energy and health, for multiple intent recognition and dialogue handling. Furthermore, in the energy domain, a scenario that demonstrates how the agent solves an implicit Demand-Response problem has been applied and evaluated. An experimental study with 36 participants further illustrates the usefulness and acceptance of the developed conversational agent-based system.
An Optimized Decision Tree with Genetic Algorithm Rule-Based Approach to Reveal the Brain’s Changes During Alzheimer’s Disease Dementia
Authors: Karami Vania , Nittari Giulio , Traini Enea , Amenta Francesco
Published: October 2021

Background: It is desirable to achieve acceptable accuracy for computer aided diagnosis system (CADS) to disclose the dementia-related consequences on the brain. Therefore, assessing and measuring these impacts is fundamental in the diagnosis of dementia. Objective: This study introduces a new CADS for deep learning of magnetic resonance image (MRI) data to identify changes in the brain during Alzheimer’s disease (AD) dementia. Methods: The proposed algorithm employed a decision tree with genetic algorithm rule-based optimization to classify input data which were extracted from MRI. This pipeline is applied to the healthy and AD subjects of the Open Access Series of Imaging Studies (OASIS). Results: Final evaluation of the CADS and its comparison with other systems supported the potential of the proposed model as a novel tool for investigating the progression of AD and its great ability as an innovative computerized help to facilitate the decision-making procedure for the diagnosis of AD. Conclusion: The one-second time response, together with the identified high accurate performance, suggests that this system could be useful in future cognitive and computational neuroscience studies.
An improved RFID anti-collision algorithm
Authors: Peng Hua
Published: October 2021

In the communication of RFID system, it is easy to cause collision during data exchange between the tag and the reader, thus tags may not be identified. On the basis of researching binary algorithm, bit positions of collision are locked through setting different statuses of the order during collision, and then samples of the locked positions are recorded to select the remaining collision positions during the paging process to the descending order. Compared with traditional binary collision algorithm, significant improvements have been made in analyzing the algorithm’s indexes like searching times, amount of communication and throughput, improving efficiency of the system.
A comparison study of chi-square and uniform distributions of mesh clients for different router replacement methods using WMN-PSODGA hybrid intelligent simulation system
Authors: Barolli Admir , Bylykbashi Kevin , Qafzezi Ermioni , Sakamoto Shinji , Barolli Leonard , Takizawa Makoto
Published: October 2021

Wireless Mesh Networks (WMNs) are gaining a lot of attention from researchers due to their advantages such as easy maintenance, low upfront cost and high robustness. Connectivity and stability directly affect the performance of WMNs. However, WMNs have some problems such as node placement problem, hidden terminal problem and so on. In our previous work, we implemented a simulation system to solve the node placement problem in WMNs considering Particle Swarm Optimization (PSO) and Distributed Genetic Algorithm (DGA), called WMN-PSODGA. In this paper, we compare chi-square and uniform distributions of mesh clients for different router replacement methods. The router replacement methods considered are Constriction Method (CM), Random Inertia Weight Method (RIWM), Linearly Decreasing Inertia Weight Method (LDIWM), Linearly Decreasing Vmax Method (LDVM) and Rational Decrement of Vmax Method (RDVM). The simulation results show that for chi-square distribution the mesh routers cover all mesh clients for all router replacement methods. In terms of load balancing, the method that achieves the best performance is RDVM. When using the uniform distribution, the mesh routers do not cover all mesh clients, but this distribution shows good load balancing for four router replacement methods, with RIWM showing the best performance. The only method that shows poor performance for this distribution is LDIWM. However, since not all mesh clients are covered when using uniform distribution, the best scenario is chi-square distribution of mesh clients with RDVM as a router replacement method.
Dual graph wavelet neural network for graph-based semi-supervised classification
Authors: Hu Kekun , Dong Gang , Zhao Yaqian , Li Rengang , Jiang Dongdong , Chao Yinyin , Liu Haiwei , Ge Yuan
Published: October 2021

Vertex classification is an important graph mining technique and has important applications in fields such as social recommendation and e-Commerce recommendation. Existing classification methods fail to make full use of the graph topology to improve the classification performance. To alleviate it, we propose a Dual Graph Wavelet neural Network composed of two identical graph wavelet neural networks sharing network parameters. These two networks are integrated with a semi-supervised loss function and carry out supervised learning and unsupervised learning on two matrixes representing the graph topology extracted from the same graph dataset, respectively. One matrix embeds the local consistency information and the other the global consistency information. To reduce the computational complexity of the convolution operation of the graph wavelet neural network, we design an approximate scheme based on the first type Chebyshev polynomial. Experimental results show that the proposed network significantly outperforms the state-of-the-art approaches for vertex classification on all three benchmark datasets and the proposed approximation scheme is validated for datasets with low vertex average degree when the approximation order is small.
Deficient Interhemispheric Connectivity Underlies Movement Irregularities in Parkinson’s Disease
Authors: Bange Manuel , Gonzalez-Escamilla Gabriel , Marquardt Tabea , Radetz Angela , Dresel Christian , Herz Damian , Schöllhorn Wolfgang Immanuel , Groppa Sergiu , Muthuraman Muthuraman
Published: October 2021

Background: Movement execution is impaired in patients with Parkinson’s disease. Evolving neurodegeneration leads to altered connectivity between distinct regions of the brain and altered activity at interconnected areas. How connectivity alterations influence complex movements like drawing spirals in Parkinson’s disease patients remains largely unexplored. Objective: We investigated whether deteriorations in interregional connectivity relate to impaired execution of drawing. Methods: Twenty-nine patients and 31 age-matched healthy control participants drew spirals with both hands on a digital graphics tablet, and the regularity of drawing execution was evaluated by sample entropy. We recorded resting-state fMRI and task-related EEG, and calculated the time-resolved partial directed coherence to estimate effective connectivity for both imaging modalities to determine the extent and directionality of interregional interactions. Results: Movement performance in Parkinson’s disease patients was characterized by increased sample entropy, corresponding to enhanced irregularities in task execution. Effective connectivity between the motor cortices of both hemispheres, derived from resting-state fMRI, was significantly reduced in Parkinson’s disease patients in comparison to controls. The connectivity strength in the nondominant to dominant hemisphere direction in both modalities was inversely correlated with irregularities during drawing, but not with the clinical state. Conclusion: Our findings suggest that interhemispheric connections are affected both at rest and during drawing movements by Parkinson’s disease. This provides novel evidence that disruptions of interhemispheric information exchange play a pivotal role for impairments of complex movement execution in Parkinson’s disease patients.
Barriers to access to clinical trial data: Obstruction of a RIAT reanalysis of the treatment for adolescents with depression study
Authors: Aboustate Natalie , Jureidini Jon
Published: October 2021

BACKGROUND: Public access to data has been a major step in attempting to reduce bias in scientific literature. Data to verify efficacy outcomes are now more accessible; however, little has been done to ensure public access to harms data from RCTs, which are equally important in ascertaining possible misreporting and protecting safety. OBJECTIVE: The treatment for adolescents with depression study (TADS) has influenced most international practice guidelines for treating children and adolescents with depression, supporting first-line prescription of fluoxetine in combination with cognitive behavioural therapy (CBT). However, after over 30 publications by the TADS team, reporting on harms remains highly deficient and we aimed to redress this lack. METHODS: In undertaking a restoring invisible and abandoned trials (RIAT) reanalysis of TADS’ effectiveness and safety outcomes, we sought access to de-identified serious adverse events (SAE) data. RESULTS: This paper describes our unsuccessful efforts to obtain more detailed SAE data from TADS’ data custodians, highlighting several problematic blocks to comprehensive safety reporting. CONCLUSION: Comprehensive access to clinical trial data is necessary to ensure safe and fully informed guidelines for treating children and adolescents with depression.
Assessment reliability parameters of the DVB-T2 broadcasting station’s equipment with local content insertion
Authors: Sai S. V. , Sorokin N. Yu. , Tissen О. V.
Published: October 2021

Local content modification provided to subscribers of the terrestrial digital television signal is necessary to provide the technical possibility of organizing inserts of local content signals, such as TV programs of regional broadcasters, as well as information on emergency situations. Broadcast multiplexes of federal TV programs are designed for use within the corresponding time zone (A, B, C, D, M). In each time zone, there are a number of regions, in each of which there are local TV and radio companies that produce local content that must be delivered to the subscribers of the whole subject. The task of embedding/modifying content at each remote transmitting station is performed by an inserter or local content insertion device (ETSI TS 102773). The reliability parameters of the restorable system for organizing terrestrial television broadcasting at a remote station with the content modification were calculated in this article. Tables and a graph of the broadcasting system states are presented, on the basis of which, systems of Kolmogorov differential equations are compiled. It was found that additional redundancy organized by connecting the output stream from the RX1 receiver directly to the transmitting device allows for a 2.5-fold increase in the average operating time between failures, as well as an increase in the availability factor by 5.26 percent. All calculations were performed using the SimInTech software package. The influence of automatic redundancy of the local content inserter and the transmitter on the occurrence of errors in the stream that affect the quality of the output signal is considered. The relationship between the availability factor and the components of the quality of service parameter – SAE, SDE and SIE is determined.
Influence of the humanitarian environment on improving the quality of training of specialists in a technical university
Authors: Savka О. G.
Published: October 2021

The article is devoted to the consideration of the theoretical aspects of the influence of the organization of the humanitarian environment in a technical educational institution on improving the quality of training specialists, increasing their competitiveness in the labor market. The analysis of special literature and generalization of different points of view on the subject of research act as research methods. The humanitarian environment represents a certain content orientation of the educational system of curricula and work programs of disciplines that include the unity of material and spiritual values that are responsible for the formation of students’ personality. Each teacher considers this problem in his own way, so the points of view have their own specifics. The humanitarian environment of the university includes a specially organized training system in which a set of specially selected methods and technologies is used to «nurture» a competitive specialist with a set of not only professional, but also personal competencies. The training of specialists in a technical university has its own characteristics related to the further professional implementation of graduates. Students at the stage of training must master special competencies, develop personal qualities, be motivated to study disciplines and master new types of activities. The organization of the humanitarian environment in the organization should be implemented at all levels: university, faculty, at each specific lesson in the study of disciplines, both provided for in the curriculum and extracurricular according to the plan of educational work. For this purpose, it is necessary to maintain and control the interaction of students with all components of the educational environment of a higher educational institution using methods such as: humanitarian technologies, mentoring, organizing a positive psychological climate in the institution, introducing additional educational programs, using active and innovative teaching methods.
THE SEAWATER AND FRESHWATER INFLUENCE ON EXPANSIVITY BEHAVIORS OF CLAY MINERALS
Authors: Widiarso Dian Agus
Published: October 2021

Semarang City is characterized by an intercalating of loam-silt and clayey units. The behavior of the clay materials in terms of its expansivity changes in the volumetric parameter when it contacts the water. Some problems in the presence of tidal flooding appears when the seawater ingress to the shoreland that causes severe damage to infrastructures. This research attempts to reveal the influence of both seawater and freshwater on the expansivity behaviors of the clayey materials based on its mineral composition. Some tests are performed to observe the volumetric changes in the clay samples after being soaked in seawater and freshwater for twenty-four hours. The X-Ray Diffraction (XRD) tests are conducted on some selected samples by using the bulk method to determine the mineral composition of the samples. The ANOVA test is also introduced in the analysis to distinguish whether the certain mineral types and its composition influencing the clay expansivity behaviors at a confidence level of about ninety-five percent and alpha (α) of about five percent. The result of this research has proven that the presence of montmorilonite minerals is the most influencing factor on the clayey expansivity behaviors when immersed in seawater and freshwater than kaolinite and illite minerals.
Comparative efficacy of the original and biosimilar eculizumab in the treatment of obstetric atypical hemolytic-uremic syndrome
Authors: Korotchaeva Y.V. , Kozlovskaya N.L. , Shifman E.M.
Published: October 2021

Obstetric atypical hemolytic-uremic syndrome (aHUS) is an emergency with an unfavorable prognosis. The implementation of the complement-blocking drug Eculizumab into clinical practice significantly improved prognosis of patients with obstetric aHUS. In 2019, the first biosimilar of Eculizumab was developed in Russia by GENERIUM.
Levilimab in patients with COVID-19 in real-life practice
Authors: Tavlueva E.V. , Ivanov I.G. , Lytkina K.A. , Plesovskiy P.A. , Bezuglaya T.V. , Fridman S.R. , Meleshkevich T.A. , Strizheletskiy V.V. , Melkonyan G.G. , Melik-Ogandzhanyan G.Yu. , Uyanaeva M.A. , Bezuglaya E.A. , Khobotnikov D.N. , Pukhtinskaia P.S. , Mladov V.V.
Published: October 2021

To evaluate the efficacy and safety of levilimab in COVID-19 patients in the real-life clinical practice.
Clinical manifestations and outcomes of Fabry disease in 150 adult patients
Authors: Moiseev A. , Moiseev S. , Tao E. , Bulanov N. , Mershina E. , Ismailova D. , Nosova N. , Kuchieva A. , Sholomova V. , Novikov P. , Pavlikova E. , Fomin V. , Safarova A.F.
Published: October 2021

To evaluate clinical manifestations and outcomes of Fabry disease (FD) in adult patients in the Russian population.
Preschool Parent's Health Education Improving Family Role Model of Fruit Vegetable Consumption
Authors: Rohayati Rohayati , Rekawati Etty , Fitriani Poppy
Published: October 2021

Prevention of obesity should start early because obesity in children can continue into adulthood. Consumption of vegetables and fruit according to the recommendations is proven to prevent obesity from an early age. The role model of parents is very important in shaping the behavior of eating fruits and vegetables in preschool children. The aim of study to determine the effect of online and face-to-face health education methods on the role models of parents in consuming fruits and vegetables. The study used a quasi-experimental design pre-post-test without a control group. The number of samples was 115 parents of students spread across 5 kindergarten schools. The results showed 49.6% of parents have graduated from high school with an income of 52.7% above the minimum wage. The results of statistical tests showed that there was an effect of online and face-to-face health education methods on the role models of parents in eating vegetables and fruit with their children (17.92 ± 4.61, p = 0.00, 95% CI). Health education using online and face-to-face methods can be an intervention in increasing parental role models of fruit and vegetable consumption.
KESELAMATAN LALU LINTAS PADA PENGEMUDI KEGIATAN PENGANGKUTAN BATU MELALUI COMPLIANCE AUDIT BERDASARKAN UNDANG-UNDANG NOMOR 22 TAHUN 2009 TENTANG LALU LINTAS DAN ANGKUTAN JALAN DI PT BATU ALAM PERSADA KECAMATAN RUMPIN KABUPATEN BOGOR 2019
Authors: Gumawang Galuh , Ginanjar Rubi , . Supriyanto
Published: October 2021

Keselamatan Lalu Lintas merupakan hak bagi setiap manusia, karena pada hakikatnya keselamatan lalu lintas menghindari resiko seseorang mengalami kecelakaan. Penelitian ini bertujuan untuk mengetahui audit kepatuhan dalam berlalu lintas di PT Batu Alam Persada Kecamatan Rumpin Kabupaten Bogor. Jenis penelitian yang digunakan adalah jenis penelitian deskriptif kuantitatif dengan metode wawancara. Pengambilan sampel ini sebanyak 100 pengemudi. Pengumpulan data yang dilakukan dengan observasi dan lembar checklis. Hasil penelitian ini menggambarkan pengemudi pada kesesuaian syarat administrasi sebnyak 60 persen, kesesuaian perlengkapan 24 persen dan kesesuaian perilaku pengemudi 34 persen. Karena kekurangan ini muncul dari pengemudi itu sendiri yang tidak memperhatikan keselamatan. Penelitian ini menyarankan kepada manajemen PT Batu Alam Persada melakukan pengkajian dan mempromosikan tentang keselamatan berlalu lintas kepada pengemudinya dan pengemudi lebih peduli terhadap keselamatannya
FAKTOR YANG BERHUBUNGAN DENGAN PELAKSANAAN USAHA KESEHATAN SEKOLAH (UKS) TINGKAT SD/MI DI WILAYAH KERJA PUSKESMAS KARANGGAN KABUPATEN BOGOR TAHUN 2020
Authors: Utami Putri , Chotimah Indira , Khodijah Parinduri Siti
Published: October 2021

Pembinaan dan pengembangan kesehatan sekolah adalah upaya pendidikan kesehatan dan dilaksanakan secara terpadu, sadar, terencana, terarah dan bertanggung jawab untuk menanamkan, tumbuh, berkembang dan membimbing hidup, dicintai dan menerapkan prinsip-prinsip hidup sehat dalam kehidupan sehari-hari, siswa yang akhirnya diharapkan dapat meningkatkan kualitas pendidikan dan prestasi peserta didik. Hasil survei awal yang dilakukan ke beberapa SD/MI yang ada di wilayah kerja Puskesmas Karanggan, masih banyak sekolah yang belum melaksanakan UKS dengan baik karena terdapat banyak kendala seperti lahan untuk ruang UKS, minimnya Sumber Daya Manusia (SDM), serta tidak adaanya anggaran untuk menunjang pengadaan sarana prasaran untuk memaksimalkan pelaksanaan UKS. Penelitian ini merupakan penelitian deskriptif kuantitatif dengan pendekatan cross sectional. Sampel penelitian ini adalah seluruh kepala sekolah dan guru UKS pada Sekolah Dasar (SD) / Madrasah Ibtidaiyah (MI) yang berada di wilayah kerja Puskesmas Karanggan dari 18 sekolah yang terdiri atas 40 orang, dengan cara total sampling. Alat pengumpulan data menggunakan kuesioner. Analisis data menggunakan uji korelasi Chi-Square (alpha 5%). Hasil uji statistik menunjukan tidak ada hubungan antara pengetahuan dengan pelaksanaan UKS (Pvalue0,183), tidak ada hubungan antara sikap dengan pelaksanaan UKS (Pvalue 0,264), terdapat hubungan antara sarana prasarana dengan pelaksanaan UKS (Pvalue 0,026), dan ada hubungan antara SDM dengan pelaksanaan UKS (Pvalue 0,000). Berdasarkan penelitian ini diharapkan adanya peran aktif dari pihak sekolah, guru maupun seluruh masyarakat sekolah dalam melaksanakan UKS, serta perlunya kerjasama antara pihak terkait lebih ditingkatkan agar pelaksanaan UKS lebih maksimal.
FAKTOR-FAKTOR YANG HUBUNGAN DENGAN KELELAHAN KERJA PADA PENGEMUDI BUS ANTAR KOTA ANTAR PROVINSI (AKAP) PT EKA SARI LORENA TRANSPORT TBK BOGOR TAHUN 2020
Authors: Maulana Reza , Ginanjar Rubi , Masitha Arsyati Asri
Published: October 2021

Kelelahan (fatigue) adalah suatu mekanisme perlindungan tubuh agar tubuh terhindar dari ke- rusakan lebih lanjut sehingga terjadi pemulihan setelah istirahat. Kelelahan diatur secara sentral oleh otak. Pada susunan syaraf pusat terdapat sistem aktivasi (bersifat simpatis) dan inhibas (bersifat parasimpatis. Penelitian ini menggunakan studi deskriptif analitik dengan desai cross sectional study. Populasi dan sampel penelitian ini sebanyak 56 responden. Teknik penelitian ini menggunakan nonprobability sampling dengan menggunakan sampling jenuh. Alat yang digunakan dalam penelitian ini menggunakan kuesioner dan alat ukur tinggi badan (microtoice) dan timbangan digital untuk mengukur berat badan untuk mengetahui indeks masa tubuh (IMT). Cara analisis data penelitian ini menggunakan perangkat lunak aplikasi statistik (SPSS 23) dengan menggunakan uji statistik chi-square. Berdasarkan hasil penelitian ini, kelelahan di PT Eka Sari Lorena Trasnport Tbk yaitu 37 orang (66,1%) yang mengalami kelelahan tinggi dan 19 orang (33,9%) yang mengalami kelelahan ringan, dan tidak ada hubungan antara semua variabel independen dan dependen yang pada penelitian ini. Kesimpulan penelitian ini tidak adanya hubungan antara waktu tidur dengan kelelaha karena kurang memanfaatkan waktu tidur dengan baik sehingga mengakibatkan kualitas tidur yang tidajk otimal.
ANALISIS PENYEBAB PENGEMBALIAN BERKAS KLAIM PASIEN BADAN PENYELENGGARA JAMINAN SOSIAL (BPJS) KESEHATAN PADA LAYANAN RAWAT JALAN TINGKAT LANJUT (RJTL) DI RUMAH SAKIT PARU DR. M. GOENAWAN PARTOWIDIGDO TAHUN 2019
Authors: Aminah Siti , Khodijah Parinduri Siti , Dwimawati Eny
Published: October 2021

Pada tahun 2018 dan 2019 terdapat berkas klaim pasien rawat jalan`yang dikembalikan oleh BPJS kesehatan kepada Rumah Sakit Paru Dr. M. Goenawan Partowidigdo yaitu sebanyak 892 berkas klaim pada tahun 2018 sedangkan pada tahun 2019 sebanyak 417 berkas klaim pasien yang dikembalikan. Penelitian ini bertujuan untuk mengetahui penyebab pengembalian berkas klaim pasien BPJS kesehatan rawat jalan dengan menggunakan kualitatif deskriptif dengan pengumpulan data melalui wawancara mendalam, observasi dan telaah dokumen/data. Populasi penelitian ini adalah 9 orang petugas klaim pasien BPJS kesehatan dipilih secara non probability sampling melalui purposive sampling dengan sampel adalah 5 orang petugas klaim pasien BPJS kesehatan rawat jalan. Hasil penelitian menunjukkan berkas klaim pasien dikembalikan karena salah entri tarif kelas rumah sakit, satu episode dengan rawat inap, diagnosa sekudner tidak dientri, tidak adanya laporan penunjang, kunjungan berulang dan ketidaklengkapan persyaratan administrasi pasien yang disebabkan karena human error petugas, penulisan diagnosa yang tidak terbaca, rumah sakit sebagai unit pelayanan tidak bisa menolak pasien, tidak adanya aplikasi yang berfungsi untuk memisahkan berkas klaim dengan satu episode rawat inap dan adanya perbedaan antara rumah sakit dengan verifikator BPJS kesehatan terkait pengelompokkan tarif kelas rumah sakit. Saran membuat SOP penulisan diagnosa dokter, menyamakan pengelompokkan tarif kelas rumah sakit antara rumah sakit dengan verifikator BPJS.
HUBUNGAN ANTARA PENGETAHUAN DAN SIKAP PENDERITA HIPERTENSI TERHADAP KEAKTIFAN PESERTA BPJS DI UPT PUSKESMAS MERDEKA KOTA BOGOR TAHUN 2018
Authors: Rohimah Kumullah Siti , Chotimah Indira
Published: October 2021

Menurut WHO, tekanan darah yang normal bagi orang dewasa adalah 120/80 mmHg. Akan tetapi, jika tekanan darah sistolik yaitu antara 130-139 dan tekanan darah distolik antara 80-89, dan itu juga masih bisa disebut dengan tekanan darah yang normal. Program Pengelolaan Penyakit Kronis (prolanis) adalah suatu sistem pelayanan kesehatan dan pendekatan proaktif yang dilaksanakan secara terintegrasi yang melibatkan peserta, fasilitas kesehatan dan BPJS Kesehatan dalam rangka pemeliharaan kesehatan bagi peserta BPJS Kesehatan yang menderita penyakit kronis untuk mencapai kualitas hidup yang optimal dengan biaya pelayanan kesehatan yang efektif dan efisien.Penelitian ini menggunakan metode penelitian kuantitatif dan pengambilan data dilakukan dengan desain Cross Sectional dengan menggunakan kuesioner. Jumlah sampel dalam penelitian ini adalah 49 responden. Cara analisa data menggunakan perangkat lunak aplikasi statistik.Hasil penelitian menunjukan bahwa sebagian besar responden memiliki pengetahuan tidak baik mengenai program pengelolaan penyakit kronis (Prolanis) (61.2%), sikap yang positif mengenai program pengelolaan penyakit kronis (Prolanis) (59.2%), keluarga yang memberikan dukungan dalam keaktifan penderita sebagian besar mendukung (63.3%). Berdasarkan tingkat keaktifan penderita hipertensi sebagian besar (51.0%) termasuk kedalam kategori aktif dalam kegiatan Prolanis. Hasil analisis menunjukan bahwa Terdapat hubungan antara pengetahuan dengan keaktifan penderita hipertensi dalam kegiatan prolanis (p- value = 0.035). Tidak terdapat hubungan antara umur (p-value = 1000), Jenis kelamin (p-value = 0.716), Pendidikan (p-value = 1000), Sikap (p-value = 0.863), dan Dukungan keluarga (p-value = 0.053) dengan keaktifan penderita hipertensi dalam kegiatan prolanis. Peneliti memberikan saran kepada Puskesmas Merdeka Kota Bogor untuk meningkatkan keaktifan masyarakat perlu direncanakan dan member tugas kepada sebagian petugas kesehatan di puskesmas untuk melakukan kunjungan home visit kerumah pasien, sehingga 4 aktivitas prolanis bisa berjalan maksimal.
TINGKAT PENGETAHUAN DAN PERILAKU MASYARAKAT JATIMULYA,KOTA DEPOK TENTANG COVID -19 DI MASA ADAPTASI KEBIASAAN BARU (AKB)
Authors: Putri Annida Naghmah Gita , Dewi Pertiwi Fenti
Published: October 2021

Saat ini usaha pencegahan dan pengendalian terhadap paparan virus Covid-19 gencar dilakukan oleh pemerintah. Hal ini berpengaruh pada pengetahuan dan perilaku masyarakat baik di kota maupun di daerah terhadap upaya pencegahan Covid-19. Adapun tujuan pengabdian masyarakat ini sebagai wujud Tri Dharma Perguruan Tinggi untuk menganalisi upaya pencegahan Covid-19 pada warga/masyarakat yang ada di Kampung Sawah RT 001 RW 003 Kelurahan Jatimulya, Kabupaten Cilodong kota Depok Jawa Barat. Hasil penelitian, responden dan sampel penelitian sebanyak 30 responden. Program penyuluhan pada warga  ini bertujuan menumbuhkan kesadaran pentingnya mematuhi protokol  kesehatan  terlebih pada masa Adaptasi Kebiasaan Baru (AKB). Metode pelaksanaan program yang digunakan terdiri dari tiga tahap yaitu (1) pengumpulan data Pre-Test; (2) penyuluhan serta sosialisasi kepada masyarakat; dan (3) pengumpulan data Post-Test. Berdasarkan hasil evaluasi menunjukkan adanya peningkatan dalam tingkat pengetahuan dan perilaku para warga mengenai penerapan protokol kesehatan walaupun hasil persentase yang didapat menunjukkan cukup signifikan. Hasil akhir dari persentase evaluasi keseluruhan menunjukkan bahwa penerapan protokol kesehatan pada masa Adaptasi Kebiasaan Baru (AKB) para warga masih memerlukan kerjasama dan peran serta berbagai pihak dalam penyuluhan dan sosialisasi lebih lanjut.