bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Interpersonal Dynamics in Wellness Tourism: A Reexamination of Intentions Through a Case Study of Generation X Citizens In Thailand
Authors: Kajornatthapol Pongwiritthon , Siyaphat Suthithananchai , Tarmthai Phataradolsopon , Thumtheang Suttipong
Published: October 2024

Objectives: This study explores the key factors influencing women’s leadership performance in crisis situations, particularly during the COVID-19 pandemic. It aims to identify the most dominant factors affecting women's leadership in regional governments in North Sulawesi, Indonesia.
 
Theoretical Framework: The research builds on theories of leadership and gender, incorporating concepts from human resource management and performance analysis. Women's leadership is viewed through the lens of gendered leadership styles, organizational behavior, and crisis management.
 
Method: A mixed-method approach was used, combining quantitative and qualitative methods. Quantitative data was collected through surveys distributed to 147 women in leadership positions across three regional governments, followed by qualitative interviews with key informants. Data was analyzed using Confirmatory Factor Analysis (CFA) to identify dominant leadership factors.
 
Results and Discussion: The findings revealed 12 key factors influencing women's leadership performance, including motivation, organizational infrastructure, work atmosphere, problem-solving abilities, and interpersonal relationships. The study highlights the importance of collaborative leadership, communication, and fairness in performance evaluations. Women leaders were found to emphasize nurturing and interpersonal relationships more than male leaders, reflecting gender-based leadership styles.
 
Research Implications: The study contributes to understanding gender-specific leadership during crises, emphasizing the need for supportive organizational structures and inclusive policies. The findings also suggest that women's leadership, with its focus on collaboration and care, plays a significant role in effectively managing crises.
 
Originality/Value: This research provides a novel contribution by focusing on women leaders in sub-national units during a global crisis, highlighting the distinct leadership strategies employed by women. It adds value by identifying factors that enhance women's leadership performance in crisis management, which has been underexplored in previous research.
Digital Media Competence in the Mexican Interactive Generation. Have Digital Competence Programs Worked in Mexico?
Authors: León-Duarte Gustavo Adolfo , Castillo Mariel Montes , Cázarez Carlos René Contreras , Rodriguez Lisset Aracely Oliveros
Published: October 2024

Objective: This research presents results of the digital media competence scale applied to Mexican youth during the period 2009-2023. With this evidence, the study is contrasted theoretically and empirically with the five major official programs on digital media competence implemented by the Ministry of Public Education of Mexico in said period.
 
Theoretical Framework: The study was adjusted to the recommendations of international organizations such as UNESCO (2018) and the European Union (Livingstone, 2019). The scale was developed and adapted from a broader study on Internet consumption habits, digital skills, and online sociability in young people (León, et al., 2013; 2014; 2015).
 
Method: A quantitative methodology of longitudinal descriptive cut was applied to present the empirical results of the scale on a sample of (N=4,753) high school students in Mexico.
 
Results and Discussion: The results obtained revealed the need to include a permanent teacher training program on literacy and basic digital skills in the field of basic education, as well as the creation of content on digital communication and information in all basic education plans and programs.
 
Research Implications: The practical and theoretical implications of this research provide sensitive information to modify future management programs within the public policy on digital culture.
 
Originality/Value: The study contributes to the specialized literature by highlighting the management challenges that the New Mexican School headed by the current government should consider. The relevance and value of the data presented show a critical and independent position in contrast to the government's positions.
К оптимизации формы и конструкций корпуса судна с системных позиций
Authors: Бугаев Виктор Григорьевич , Дам Ван Тунг , Китаев Максим Владимирович , Новиков Валерий Васильевич
Published: October 2024

Изложен достаточно простой и эффективный способ оптимизации формы и конструкций корпуса судна с системных позиций с учетом ходкости, продольной прочности и кручения. Сформулированы три взаимоувязанные задачи: 1) оптимизация формы корпуса с целью обеспечения ходкости по критерию минимума сопротивления воды движению судна и требований к прочности и технологичности конструкций; 2) расположение помещений, размещение грузов и запасов для обеспечения заданной посадки и остойчивости, моделирования изгибающих моментов и перерезывающих сил на тихой воде и на волнении, определения напряженно-деформированного состояния конструкций (на основе эквивалентного бруса); 3) оптимизация конструкций корпуса судна по критериям минимума массы и (или) себестоимости их изготовления. Приведены результаты оптимизации формы корпуса и элементов эквивалентного бруса судна, которые позволяют выявить наилучшие проектные и конструктивные решения и оценить экономический эффект. Особое внимание уделено удифферентовке судна, определению напряжений и перемещений в связях корпуса на тихой воде, на вершине и подошве волны (при прогибе и перегибе судна), на косой волне (при кручении).

A fairly simple and effective method of optimizing the shape and structure of the ship's hull from a system position, taking into account performance, longitudinal strength and torsion, is presented. Three interrelated tasks are formulated: the first is to optimize the shape of the hull in order to ensure performance according to the criterion of minimum resistance of water to the movement of the vessel and the requirements for the strength and manufacturability of structures; The second is arrangement of premises, placement of cargo and supplies to ensure the specified fit and stability, simulation of bending moments and shear forces in still water and in rough seas, determination of the stress-strain state of structures (based on an equivalent beam). Optimization of the hull shape and elements of the equivalent beam of the vessel are presented, which make it possible to identify the best design and structural solutions and assess the economic effect. Particular attention is paid to the trimming of the vessel, determination of stresses and displacements in the hull connections in still water, at the top and bottom of the wave (during deflection and bending of the vessel), on an oblique wave (during torsion).
Усиления корпусов судов, швартующихся в море
Authors: Кузнецов Эдуард Александрович , Кулеш Виктор Анатольевич
Published: October 2024

Одним из наиболее опасных случаев в эксплуатации судна, наряду с работой во льдах, является проведение швартовных операций в море. В отличие от швартовных операций в портах к причалам, швартовка на волнении в открытом море осложняется тем, что суда перемещаются друг относительно друга. В результате нагрузка на бортовые конструкции судна значительно возрастает. Правила Российского морского регистра судоходства требуют установку дополнительных усилений бортов и надстроек на судах, швартующихся на волнении от 4 до 6 баллов. Данные требования появились в Правилах довольно давно и за годы существования претерпевали значительные изменения. Действующие на данный момент требования имеют ряд недостатков, обусловленных методом расчета интенсивности давления швартующихся судов. В работе показаны недостатки Правил и предложены методы решения указанных проблем.

One of the most dangerous cases in the operation of a vessel, along with working in ice, is mooring operations at sea. Unlike mooring operations in ports to berths, mooring on the waves in the open sea is complicated by the movement of ships relative to each other. As a result, the load on the ship's side structures increases significantly. The rules of the Russian Maritime Register of Shipping require the installation of additional reinforcements of the sides and superstructures on ships moored in waves from 4 to 6 points. These requirements appeared in the Rules quite a long time ago and have undergone significant changes over the years. The currently existing requirements have a number of disadvantages due to the method of calculating the pressure intensity of moored vessels. The paper shows the existing shortcomings of the Rules and suggests methods for solving these problems.
Проектирование подкреплений бортовых перекрытий танкера для безопасной эксплуатации в ледовых условиях
Authors: Суров Олег Эдуардович , Ю Кан Сон
Published: October 2024

В статье представлены результаты обоснования оптимального выбора геометрических характеристик подкреплений корпуса танкера «Остров Русский» на ледовый класс Ice1 по требованиям Российского морского регистра судоходства с целью обеспечения местной прочности при эксплуатации судна во льдах. Для проверки местной прочности бортовых перекрытий выполнялись расчеты напряженно-деформированного состояния конструкций с использованием метода конечных элементов. Рассмотрены разные способы разбиений конечных элементов в программном продукте САПР Solidworks Simulation и выбран оптимальный размер расчетной сетки. Достоверность полученных результатов расчетов проверена по критерию влияния устанавливаемых конструктивных элементов на прочность бортовых перекрытий. В результате сравнения трех вариантов ледовых подкреплений с точки зрения обеспечения прочности и экономичности конструкции выбрана оптимальная схема усиления бортов судна. По результатам выполненных расчетов разработан проект подкреплений корпуса танкера «Остров Русский» на ледовый класс Ice1 и согласован в Российском морском регистре судоходства.

In this article the results of substantiating the optimal choice of geometric characteristics of the hull strengthening tanker "Ostrov Russkiy" for ice class Ice1 according to the requirements of the Rules Russian Maritime Register of Shipping in order to ensure local strength when operating ship in ice are presented.To check the local strength of the side construction, calculations of the stress-strain state of structures using the finite element method were performed. Various methods of partitioning finite elements in the CAD software Solidworks Simulation are considered and the optimal size of the computational mesh is selected. The reliability of the calculation results obtained was verified by the criterion of the influence of the installed structural elements on the strength of the side construction. As a result of comparing three options for ice reinforcements, from the point of view of ensuring the strength and cost-effectiveness of the structure, the optimal scheme for strengthening the sides of the vessel was selected. Based on the results of the calculations, a design for reinforcement of the hull of the tanker "Ostrov Russkiy" for ice class Ice1 was developed and approved by the Russian Maritime Register of Shipping.
Изменение пропульсивных характеристик транспортных судов в процессе эксплуатации
Authors: Кучеров Владимир Никанорович , Огай Сергей Алексеевич , Соболенко Анатолий Николаевич , Горелик Геннадий Бенцианович
Published: October 2024

В статье приводится анализ результатов натурных замеров гидродинамических характеристик судна, с главной машины – дизелей фирмы MAN B&W LMC 50, проводимых в реальных условиях эксплуатации в районах плавания с высокой интенсивностью обрастания корпуса (моря Юго-Восточной Азии). Для сравнения приведены результаты изменения средней нагрузки на двигатель 5RD68 транспортного рефрижератора в условиях эксплуатации в районах плавания с нормальной интенсивностью обрастания. Выполненные замеры сохраняют актуальность, так как позволяют подтвердить применяемые методики оценки пропульсивных качеств судна в эксплуатации. Показана существенная разница в приросте потребной мощности главного двигателя при разных условиях плавания.Полученные результаты могут быть применены для приближенных оценок влияния пропульсивных характеристик судна на теплонапряженное состояние судовых главных энергетических установок и при назначении мощности полного хода.

The article provides an analysis of the results of full-scale measurements of the hydrodynamic characteristics of the vessel, from the main engine – MAN B&W LMC 50 diesel engines, carried out under real operating conditions in navigation areas with a high intensity of hull fouling (the seas of Southeast Asia). For comparison, the results of changes in the average load on the 5RD68 transport refrigerator engine under operating conditions in navigation areas with normal fouling intensity are presented. The uniqueness of the measurements carried out maintains their relevance, as it allows us to confirm the applied methods for assessing the propulsion qualities of the vessel in operation. A significant difference in the increase in the required power of the main engine under different sailing conditions is shown.The results obtained can be used for approximate estimates of the influence of the ship's propulsion characteristics on the thermally stressed state of the ship's main power plants and when assigning full speed power.
Проблемы идеологии в исследовании образования
Authors: Краевский Володар Викторович , Коршунова Наталья Леонидовна
Published: October 2024

Сегодня мы публикуем малоизвестный доклад ученого, подготовленный им для семинара, состоявшегося 23 апреля 2010 г. в Москве в Институте управления образованием РАО, уже без В.В. Краевского, после его ухода из жизни. На том памятном семинаре обсуждались идеологические аспекты методологического обеспечения научных исследований применительно к образованию. В соответствии со спецификой темы и переживаемого страной исторического перелома автор определяет необходимость рассмотрения трёх взаимосвязанных обширных блоков проблем, возникающих, во-первых, в сфере общих представлений об идеологии, во-вторых, в анализе состояния образования как объекта влияния идеологии и, в-третьих, в процессе исследования образования, так или иначе подверженном воздействию идеологии.

Today we publish a little-known report by the scientist, prepared by him for a seminar held on April 23, 2010 in Moscow at the Institute of Education Management of the Russian Academy of Education, already without V.V. Kraevsky, after his death. At that memorable seminar, ideological aspects of methodological support for scientific research in relation to education were discussed. In accordance with the specifics of the topic and the historical turning point experienced by the country, the author determines the need to examine three interconnected extensive blocks of problems that arise, firstly, in the sphere of general ideas about ideology, secondly, in the analysis of the state of education as an object of influence of ideology and, thirdly, in the process of studying education, one way or another subject to the influence of ideology.
Emotional Suffering of Parents in Judicial Proceedings for Variation of Custody Arrangements
Authors:   Mental Health Research Group, Mateo-Fernández Pedro V
Published: October 2024

The emotional distress of parents during court proceedings to change custody is crucial in forensic psychology.
New diagenetic constraints for the interpretation of Neoarchaean stromatolitic dolostone geochemical composition and their palaeoenvironmental significance
Authors: Franchi F. , Glynn S.M. , Hoogland V. , Davies G.R.
Published: October 2024

The stromatolitic dolostones of the Ramonnedi Formation in the Lower Transvaal Supergroup of Botswana formed along a shallow carbonate platform during the transition between the Archaean and Proterozoic eons. These dolostones are bound to reveal more details of the mechanisms and timing of Earth oxygenation and particularly the role of microbial communities in the formation of carbonate platforms in the Archaean; but only if we are able to discriminate what signature is pristine and what is due to diagenetic overprinting.

Here, the focus is on the isotopic composition of stromatolitic dolostone, pyrite grains and chert laminations found within the Ramonnedi Formation. Oxygen and carbon isotopes were investigated from the Ramonnedi Formation stromatolitic dolostones in order to constrain chemo-physical conditions at the time of deposition and, eventually, evaluate to what extent the system was re-set during diagenetic processes. In situ δ34S and δ18O compositions were determined by secondary ionisation mass spectrometry (SIMS) from pyrite and chert, respectively.

These novel results complement previous analyses and reveal that: (i) the pyrite grains are not common in the dolostones and when present have sulphur isotope compositions that point toward abiotic formation; (ii) dolostone δ13CVPDB values between -1.2 and -0.7‰ are close to marine values and might reflect pristine Archaean signature; (iii) the dolostone δ18OVPDB values, between -9 and -11‰, on the other hand, might reflect diagenetic resetting or very warm Archaean seawater, in line with the δ18O values from the chert laminae in the upper Ramonnedi Formation. (iv) The correct interpretation of these results has important implications in the interpretation of the geochemical proxies coming from the lower Transvaal Supergroup carbonate platform and for the interpretation of the onset of the Great Oxidation Event (GOE). Aim of this work is to complement the existing data on the Lower Transvaal Supergroup of Botswana and assess to what extent the geochemistry of these dolostone was overprinted during diagenesis/metasomatism. These results indicate that a multi-analytical approach is required to ensure the correct interpretation of geochemical proxy data related to the onset of the GOE.
Cooperative Mission Planning Using Rollout Policy Optimization
Authors: Hajkarim Sina M. H. , Menon Prathyush P. , Ghose Debasish
Published: October 2024

This paper proposes a novel cooperative mission planning for uncrewed aerial systems (UAS), using roll-out policy optimization and a blend of straight and double-Archimedean-spiral (DAS) paths. Typical mission tasks using UAS, possibly multiple, include visiting distinct locations/waypoints and covering specific areas of interest (AOIs). For the UAS, to guarantee the coverage of the AOI, the algorithm generates a DAS path that even accounts for the sensor’s field-of-view constraints. A scalar spiral density parameter in the algorithm effectively provides customized adjustments to the length of the DAS over an AOI while developing mission plans. A lower and upper bound value for the spiral density parameter and the dependency of the parameter on the coverage of an AOI are derived. This scalar parameter gives the users potential flexibility in the design of mission plans. Roll-out policy optimization minimizes the overall path length for the cooperative UAS mission and, as a direct consequence, minimizes time and fuel. This method leads to finding a near-optimal path in that the computation time does not grow exponentially with the number of UAS. Results from the simulation studies with several cooperative mission scenarios, including multiple UASs visiting several waypoints and AOIs starting from identical and distinct initial locations, demonstrate the efficacy of the proposed concept. The results from a data-based complex test case using the LiDAR data set further demonstrate the adaptability of the proposed mission planning approach in a real-world setting.
Multiple knee ligament tear: Magnetic Resonance imaging diagnosis
Authors: Segatt Pedro Henrique , Prado José Luiz Masson de Almeida , Shimidu Henrique , Duarte Márcio
Published: October 2024

The rupture of the anterior cruciate ligament is common during physical activities; however, when associated with a multiple ligament injury, it represents an uncommon condition. The diagnosis of this injury is commonly delayed or missed. Consequently, the incidence of this injury may in fact be higher than reported. We present a case of a 27-year-old man with complete tear of the anterior cruciate ligament and of the medial collateral ligament and partial tear of the posterior cruciate, lateral collateral and patellar ligaments treated surgically.
Archiving MigOst : Erpobung & Erkenntnisse April 2023 - März 2024
Authors:   Technische Universität Dresden, Le van Paolo , Wetschel Nick ,   Institut für Sächsische Geschichte und Volkskunde
Published: October 2024

Die Institutionalisierung von Migrant:innen(selbst)organisationen (MSO) in (größeren) Städten der DDR bzw. den neuen Bundesländern ist als ein Effekt des Umbruchs von 1989/90 zu verstehen. Neben Räumen des (interkulturellen) Austauschs und der Information geht es den sich entwickelnden MSO um Fragen des Bleiberechts für Vertragsarbeiter:innen, des politischen Asyls, um Unterstützung von Bürgerkriegsflüchtlingen, die „Integration“ von Spätaussiedler:innen und nicht zuletzt um Alltagsrassismus und rechte Gewalt. Im öffentlichen Diskurs bleiben migrationsgesellschaftliche Themen dagegen lange Zeit unterbelichtet. Das Projekt „Archiving MigOst“ setzte sich mit der frühen Phase der Organisation und Institutionalisierung von MSO und deren Rolle im Transformationsprozess auseinander (ca. 1989-2000), indem es die Selbstarchive der MSO sondierte, erschloss und für die Nachnutzung von Wissenschaft sowie MSO selbst zugänglich machte. Die Sicherung und Erschließung solcher Wissensbestände in nicht-öffentlichen Selbstarchiven ist als gesamtgesellschaftlich relevant erkannt worden. Um den Charakter der Selbstarchive zu wahren, nutzte „Archiving MigOst“ einen partizipativen Zugang: Gemeinsam mit fünf beteiligten MSO in Dresden wurden Archivwerkstätten konzipiert und umgesetzt. Die Projektarbeit ist in dieser Broschüre nachlesbar. Gefördert wurde das Projekt durch Die Bundesstiftung zur Aufarbeitung der SED-Diktatur.
Efeitos do input na aquisição de PE L2: o caso dos objetos nulos
Authors: Teixeira Joana , Fiéis Alexandra , Madeira Ana
Published: October 2024

Este estudo investiga a aquisição de objetos nulos em português europeu (PE) como L2, utilizando uma tarefa de produção oral induzida e duas tarefas de juízos de aceitabilidade rápidos (escrita e oral). Os participantes são 25 falantes de PE L1 e 30 aprendentes adultos de espanhol L1 e PE L2 nos níveis intermédio a quase nativo. Os resultados mostram que os falantes de PE L1 e L2 produzem e aceitam clíticos significativamente mais do que objetos nulos. Relativamente aos objetos nulos, o grupo nativo apresenta efeitos significativos de animacidade (a aceitação é maior com um antecedente inanimado) e de acessibilidade (a aceitação é maior com um antecedente imediatamente acessível). Os grupos de L2 não apresentam efeitos de animacidade nem de acessibilidade, mesmo no nível quase nativo. Estes resultados mostram que os aprendentes de L2 podem ter dificuldades permanentes tanto na interface sintaxe-discurso como na interface sintaxe-semântica quando a construção que está a ser adquirida é pouco frequente no input e a L1 difere da L2.
Desenvolvimento de estruturas de subordinação na escrita: estudo longitudinal com crianças de 1.º ciclo
Authors: Batalha Joana , Cardoso Aida , Lobo Maria
Published: October 2024

O presente estudo procura aprofundar o desenvolvimento longitudinal da complexidade sintática na escrita, em fases iniciais de desenvolvimento. Parte-se da hipótese de que o uso de estruturas de subordinação contribui para a caracterização da complexidade sintática em produções escritas, nomeadamente em narrativas produzidas nos primeiros anos de escolaridade. Concretamente, procurou-se dar resposta às seguintes questões de investigação: (i) Que estruturas de subordinação são mais frequentes em narrativas produzidas em quatro momentos distintos do percurso escolar?; (ii) Existe um aumento em número e em diversidade nas estruturas de subordinação usadas?; (iii) É possível identificar diferentes perfis de desenvolvimento relativamente à produção de estruturas de subordinação na escrita? Para responder a estas questões,  foi reunido e analisado um conjunto de produções escritas que permitisse observar a evolução na produção de diferentes estruturas de subordinação. O corpus inclui 172 textos, produzidos por 43 crianças de 1.º ciclo falantes de português europeu em momentos distintos do percurso escolar (início e fim do 2.º ano de escolaridade, e início e fim do do 3.º ano de escolaridade). As categorias de análise consideradas foram o tipo de oração subordinada (adverbial; relativa; completiva) e o subtipo de oração subordinada (e.g., adverbial temporal, condicional, final, causal; relativa de sujeito, de objeto, livre). Globalmente, os resultados permitem caracterizar a escrita das crianças quanto ao tipo, número e diversidade de estruturas de subordinação usadas ao longo do tempo. Complementarmente, da análise das produções individuais das crianças, foi possível identificar diferentes perfis de desenvolvimento. De um modo geral, o estudo apresenta evidências para se concluir que a subordinação é um indicador relevante para a caracterização de produções escritas iniciais.
Nota Prévia
Authors: Costa Ana Luísa , Fiéis Alexandra , Flores Cristina
Published: October 2024

Nota Prévia ao n.º 11 da RAPL.
Active Site Plasticity of the Bacterial Sliding Clamp
Authors: Raza Zahra , El Salamouni Nehad , McElroy Andrew , Skropeta Danielle , Kelso Michael , Oakley Aaron , Dixon Nicholas , Yu Haibo
Published: October 2024

The rise of antibiotic resistance poses a severe global threat, specifically due to the emergence of multi- resistant bacteria named ESKAPE pathogens which are responsible for countless deaths globally. Consequently, the development of novel antibiotics is in dire need. Targeting proteins essential to DNA replication is a promising pathway, making the β-sliding clamp (β-SC) an attractive target. Currently, there are no antibiotics on the market that target the β-SC. However, numerous compounds are being investigated to create an antibiotic with high potency against a broad range of bacterial species. Interestingly, most proposed compounds do not bind to the entire active site which may reduce their potential as high potency inhibitors. This is due to the active site residue Met at position 362, adopting a “closed” conformation, preventing inhibitors access into Subsite II of the active site. This study explored the effect of key residues on the plasticity of the β-SC active site using molecular dynamics and metadynamics simulations under different physiological states. Our results show that the Met gate exhibits flexibility and both open and closed states are thermodynamically and kinetically accessible.
One-Pot Synthesis of Core-Shell Au@mSiO2 Nanoparticles for Photothermal Applications
Authors: Montero-Oleas Andrea , Martinez Ricci María Luz , Ortiz Guillermo Pablo , Trens Phillippe , Roupioz Yoann , Kodjikian Stéphanie , Marchi M. Claudia , Cattoën Xavier , Bilmes Sara
Published: October 2024

Gold-mesoporous silica (Au@mSiO2) core-shell nanoparticles (NPs) hold great promise for application in nanomedicine, as they enable the photostimulated release of guest molecules located within their pores. In this study, prioritizing the achievement of atom economy, we used a one-pot synthesis protocol, to produce core-shell Au@mSiO2 NPs from a properly defined precursor state. Upon sodium hydroxide addition, the formation of gold NPs occurs quickly, followed by the formation of a silica shell, eliminating the need to isolate the gold cores. We conducted a comprehensive mechanistic analysis that elucidates the relative kinetics of gold and silica formation, identifying key factors for fine-tuning NPs within the size range of 50 to 100 nm, ideal for biological applications. The photothermal properties of such Au@mSiO2 were characterized and modelled. Under the experimental conditions typically used for cargo release experiments, the model predicts a temperature increase for a single particle of less than 10^(-4) °C, demonstrating that the release is due to the collective heating of the medium by a myriad of NPs rather than by the temperature elevation of individual NPs under irradiation. Overall, the studies developed here will enable more effective design and preparation of Au@mSiO₂ particles, optimizing them for a broad range of photothermal applications.
Co-evolution ligands to Tecovirimat-resistant F13L mutations of MonkeyPox Virus
Authors: coll julio
Published: October 2024

Because of the emergence of F13L mutations in MonkeyPox Virus (MPXV)-infected patients with resistances to Tecovirimat-treatment, alternative drugs are actively searched. Aiming to help on these searches, computational strategies to generate rather than screen for new drug-like ligand candidates were explored here. Ligands were predicted by i) thousands of Tecovirimat-derived children generated by co-evolution fitting predicted docking cavities at either F13L1 or F13L2, and ii) docking Tecovirimat-derived top-children to F13L-mutant resistant models isolated from Tecovirimat-treated patients. Top-children-fitting F13L-mutant docking-cavities predicted novel scaffolds, nanoMolar affinities, high specificities, absence of known toxicities and similar conservation of their targeted Tecovirimat-docking cavities. Despite their limitations, similar proved-on-concept strategies might be fine-tuned to computational explore for new drugs docking to most prevalent Tecovirimat-resistance mutations.
Generation of connections between protein sequence space and chemical space to enable a predictive model for biocatalysis
Authors: Paton Alexandra , Boiko Daniil , Perkins Jonathan , Cemalovic Nicholas , Reschützegger Thiago , Gomes Gabe , Narayan Alison
Published: October 2024

The application of biocatalysis in synthesis has the potential to offer dramatically streamlined routes toward target molecules, exquisite and tunable catalyst-controlled selectivity, as well as more sustainable processes. Despite these advantages, biocatalytic synthetic strategies can be high risk to implement. Successful execution of these approaches requires identifying an enzyme capable of performing chemistry on a specific intermediate in a synthesis which often calls for extensive screening of enzymes and protein engineering. Strategies for predicting which enzyme is most likely to be compatible with a given small molecule have been hindered by the lack of well-studied biocatalytic reactions. The under exploration of connections between chemical and protein sequence spaces constrains navigation between these two landscapes. Herein, this longstanding challenge is overcome in a two-phase effort relying on high throughput experimentation to populate connections between substrate chemical space and biocatalyst sequence space, and the subsequent development of machine learning models that enable the navigation between these two landscapes. Using a curated library of α-ketoglutarate-dependent non-heme iron (NHI) enzymes, the BioCatSet1 dataset was generated to capture the reactivity of each biocatalyst with >100 substrates. In addition to the discovery of novel chemistry, BioCatSet1 was leveraged to develop a predictive workflow that provides a ranked list of enzymes that have the greatest compatibility with a given substrate. To make this tool accessible to the community, we built CATNIP, an open access web interface to our predictive workflows. We anticipate our approach can be readily expanded to additional enzyme and transformation classes, and will derisk the application of biocatalysis in chemical synthesis.
Transforming innovative educational practices for environmental sustainability
Authors: Muhammed K. V.
Published: October 2024

This study investigates integrating pedagogical practices to foster environmental sustainability within educational settings. A mixed method was adopted to conduct in various schools across Kerala, India, from 2023 to 2024. This study examines a diverse sample of nine educational institutions selected through random sampling, focusing on experiential learning, project-based learning, interdisciplinary approaches, and the use of technology to enhance environmental education. This study identifies best practices and effective strategies for embedding sustainability concepts across the curriculum by employing a comprehensive review of the literature and analyzing case studies. The findings emphasize the role of collaborative learning, critical thinking, and service learning in promoting sustainability. This paper highlights the importance of creating eco-schools and green campuses, involving families and communities, and providing professional development for educators. This study concludes that a multi-faceted approach, incorporating ethical discussions, personal responsibility, and continuous assessment and feedback, is crucial for cultivating a generation of environmentally conscious individuals. These pedagogical practices not only enhance students' knowledge and skills but also instill a deep sense of sustainability, preparing them to tackle the complex challenges of sustainability in their personal and professional lives.
Categorizing and defining the dominance and suppression into positive and negative conscious, subconscious and unconscious mind states
Authors: Shruthi Sukhadev Jarali
Published: October 2024

This study investigates biological interactions and social structures within psychological frameworks in different manifestations of dominance and suppression classifying into conscious, subconscious, and unconscious mind states by looking at empirical research and theoretical models. This paper then details their mechanisms and impacts on individual and group behavior by looking into intentional, semi-intentional, and non-intentional mechanisms, respectively. This study explores the role that dominance and suppression play in forming social and biological hierarchies as well as individual psychologies, in addition to outlining the traits and outcomes of each type. The results are intended to advance knowledge of power relations in various contexts and offer new perspectives on the advantages and disadvantages of dominance and suppression.
Varieties and cooking conditions difference in quality of instant brown rice
Authors: Loan L.T.K. , Vinh B.T. , Tai N.V.
Published: October 2024

Amylose content is an important indicator that determines the hardness and softness of
rice, which depends on rice varieties. Three types of specialty colored rice in Vietnam
were selected for research on instant rice production including DH6 brown rice (DH6),
Huyet Rong rice (HR), and Cam Cai Lay rice (CL). Proximate compositions and
antioxidant properties such as total anthocyanin and total phenolic content in three kinds
of rice were analyzed and compared. In addition, the effect of varieties and ratios of rice
and water on the cooking time, volume expansion, antioxidant compounds and sensory
properties were observed. The results showed that varieties led to differences in the
nutritional profile of rice. CL and HR have the highest anthocyanin content (54.9-56.5
mg/100 g). DH6 brown rice is considered as the low amylose rice, with the content of
amylose about 4.6%. Besides, it was also found that using “Cam Cai Lay” rice could
create products with good structure and high sensory value. The results also confirmed
that the product is of good quality when using a ratio of rice: water 1:2 and a cooking time
of 30 mins. Types of rice and cooking conditions remarkably affected the quality of
instant rice, which could further optimize for the up-scale process.
The effects of Moringa oleifera leaves on the nutritional status of children under
five years
Authors: Sakung J.M. , N. Aisyah , Suryantara B. , Adrianton  , Jamaluddin
Published: October 2024

Children's health status is important for determining the human quality of life. Thus, the
first life of a newborn child is critical because the consequences of disturbances that occur
in children can be permanent. Moringa oleifera has been known as a miracle tree with
many health benefits, including for children. The study aimed to evaluate the effect of
Moringa oleifera in different forms (boiled soup and biscuit) in improving the nutritional
status of children under five years old. The study was a quasi-experiment with a pre-posttest non-equivalent control group design. The sampling technique used was purposive
sampling, with a total of forty-eight participants divided into two groups (24 participants
for the Moringa soup group and 24 participants for the Moringa biscuit group). The
interventions were given for 30 days. The result shows that children's weight was
significantly altered after the intervention in both groups (p<0.001). Height was not
significantly changed after the intervention in the Moringa soup group (p = 0.100) and in
the Moringa biscuit group (p = 0.317). In conclusion, both Moringa soup and biscuits
effectively improve weight in children under five years of age.
Characterization of chemical properties of fish-flavoured spicy tamarind cube
Authors: Khairuddin N. , Muhammad N. , Anas M.A. , Rahim N.F.A.
Published: October 2024

Fish-flavoured spicy tamarind cube is categorized as a type of bouillon cube. It is a
processed food that has been developed and benefits the consumers due to low cost, being
ready to use, reduced cooking time and giving intense flavour to the cooking dish. Food
processing improves the stability, safety, taste and makes the food healthier. While there
are various advantages to processing, the chemical food characteristics might be adversely
affected. The study aimed to evaluate the amount of chemical composition,
macromolecule, phytochemical content, peroxide value and antioxidant activity present in
the fish-flavoured spicy tamarind cube. The analysis was performed using a different
methodology. The content of mineral and ascorbic acid of the cube was evaluated by
using scanning electron microscopy-energy dispersive X-ray (SEM-EDX) and titration
methods respectively. Carbohydrate was estimated by difference using equation and
protein by micro Kjeldahl method. For both phytochemical compounds, total phenolic and
flavonoid are measured spectrophotometrically in this study. In addition, peroxide value
was determined by titration method and antioxidant activity was assayed using 2,2-
diphenyl-1-picrylhydrazyl (DPPH) free radical. The result showed the cube contained
2.12% sodium, 1.22% copper and 0.43% potassium while the ascorbic acid value was
66.00 mg/100 g. The macromolecule content recorded was 40.15 g/100 g for
carbohydrates and 7.54 g/100 g for protein. The cube had 10.77 mg GAE/g and 21.72 mg
QE/g for total phenolic and flavonoid respectively. The peroxide value of the cube was
9.52 meq/kg and classified in a moderate oxidation state. Furthermore, the half-maximal
inhibitory concentration (IC50) for antioxidant activity analysed was 89.04 µg/mL which
means the cube shows intermediate antioxidant activity. Based on the result, the cube is
safe to consume and can provide health benefits to consumers.
Nanocellulose as Sustainable Eco-friendly Nanomaterials: Production, Characterization, and Applications
Authors: Shanmugam Kirubanandan
Published: October 2024

Nanocellulose is a biodegradable nanomaterial derived from lignocellulosic biomass through mechanical, chemical, or enzymatic defibrillation processes to convert wood fibers into nanofibrils. This material consists of a network of cellulosic fibrils with a wide range of diameters, offering unique properties suitable for various functional applications. Nanocellulose can act as a substrate or coating, serving as an eco-friendly alternative to synthetic plastics. Despite having good barrier properties and strong mechanical strength, nanocellulose films are still not as effective as synthetic plastics. They are used in creating barrier materials, flexible electronics, and coatings for paper products.
Influence of Carbon Content on Element Diffusion in Silicon Carbide-Based TRISO Composite Fuel
Authors: Wang Xiaojiao , Zhu Libing , You Yan , Zhang Zhaoquan
Published: October 2024

The coating layers of Tri-structural Isotropic Particles (TRISO) serve to protect the kernel and act as barriers to fission products. Sintering aids in the silicon carbide matrix variably react with TRISO coating layers, leading to the destruction of the coating layers. Investigating how carbon content affects element diffusion in silicon carbide-based TRISO composite fuel is of great significance for predicting reactor safety. In this study, silicon carbide-based TRISO composite fuels with different carbon contents were prepared by adding varying amounts of phenolic resin to the silicon carbide matrix. X-ray diffraction (XRD) and Scanning Electron Microscopy (SEM) were employed to characterize the phase composition, morphology, and microstructure of the composite fuels. The elemental content in each coating layer of TRISO was quantified using Energy-Dispersive X-ray Spectroscopy (EDS). The results demonstrated that the addition of phenolic resin promoted the uniform distribution of sintering aids in the silicon carbide matrix. The atomic percentage (at.%) of aluminum (Al) in the pyrolytic carbon layer of the TRISO particles reached its lowest value of 0.55% when the phenolic resin addition was 1%. This is because the addition of phenolic resin caused the Al and silicon (Si) in the matrix to preferentially react with the carbon in the phenolic resin to form a metastable liquid phase, rather than preferentially consuming the pyrolytic carbon in the outer coating layer of the TRISO particles. The findings suggest that carbon addition through phenolic resin incorporation can effectively mitigate the deleterious reactions between the TRISO coating layers and sintering aids, thereby enhancing the durability and safety of silicon carbide-based TRISO composite fuels.
Design and Implementation of USB Key System Based on Dual-Factor Identity Authentication Protocol
Authors: Wang Jianxin , Xu Zifan , Chang Xiangze , Xiao Chaoen , Zhang Lei
Published: October 2024

With the increasing demand for information security, traditional single-factor authentication technology can no longer meet security requirements. To this end, this paper proposes a Universal Serial Bus (USB) Key hardware and software system based on a two-factor authentication protocol, aiming to improve the security and reliability of authentication. This paper first analyzes the current status and technical principles of USB Key-related research domestically and internationally and designs a two-factor authentication protocol that combines impact/response authentication and static password authentication. The system consists of a host computer and a USB Key device. The host computer interacts with the USB Key through a graphical user interface. The Secure Hash Algorithm 1 (SHA-1) and MySQL database are used to implement the authentication function. Experimental results show that the designed two-factor authentication protocol can effectively prevent replay attacks and information tampering, and improve the security of authentication. If the corresponding USB Key is not inserted, the system will prompt that the device is not found. Once the USB Key is inserted, user identity is confirmed through two-factor verification, which includes impact/response authentication and static password authentication.
Design of a Technology Verification Platform for Space Electromagnetic Interference Signal Testing and Analysis
Authors: Liu Qi , Du Huiwen , Zhang Chao , Zhang Yazhou
Published: October 2024

This paper designs a space electromagnetic interference signal test and analysis technology verification platform. The article firstly introduces the general scheme of the technical verification platform and then describes each component unit of the hardware and the overall structure of the software in detail. The platform can achieve a 10 MHz ~ 50 GHz working frequency band, 1.2 GHz acquisition and real-time recording bandwidth, 6 GB/s recording rate, and 12 TB recording capacity.
Design and Analysis of Terminal Guidance Law for Kinetic Interceptors based on Pulse Engine
Authors: Li Shixin , Ma Jia , Yue Shuai
Published: October 2024

A new terminal guidance law is proposed based on a solid propellant pulse engine and an improved proportional navigation method to address the terminal guidance issue for kinetic interceptors. On this basis, the start-stop curve of the pulse motor during the terminal guidance process is designed, along with its start-up logic. The effectiveness of the proposed guidance strategy is verified through simulation.
Design and Implementation of the Employment Management Decision Support System based on Machine Learning
Authors: Ma Zhigang
Published: October 2024

To address the challenges of current college student employment management, this study designed and implemented a machine learning-based decision support system for college student employment management. The system collects and analyzes multidimensional data, uses machine learning algorithms for prediction and matching, provides personalized employment guidance for students, and provides decision support for universities and enterprises. The research results indicate that the system can effectively improve the efficiency and accuracy of employment guidance, promote school-enterprise cooperation, and achieve a win-win situation for all parties.
Design of Signal Lamp Filament Monitoring Alarm Instrument
Authors: Zhu Haifeng
Published: October 2024

To improve the reliability of the light emitting diode (LED) signal lamp filament current monitoring alarm instrument for metro systems, a new type of hot standby online monitoring apparatus was developed which is based on synchronous transmission data (STD) bus technology. In this system, a double hot standby mode can be achieved by adopting bus arbitration. In addition, to detect the effective value of alternating current which is from 0 to 200 mA in the signal lamp lighting circuit, a precision rectifier signal conditioning circuit and an isolated acquisition circuit were designed. This new type of alarm instrument has high detection accuracy and could meet the functional requirements for metro signal systems after comparing it with some industry products that were applied on the spot.
Application Analysis of BIM Technology in Construction Engineering Cost Management
Authors: Ma Rui
Published: October 2024

With the rapid development of information technology, Building Information Modeling (BIM) technology has gradually occupied an important position in the construction industry. With the introduction of BIM technology, the cost control of construction projects can be greatly improved [1]. The use of this technology can not only reduce the project approval time but also improve the quality of the project. In addition, it can also help the construction personnel to solve the project changes, maintenance costs, insurance rates, and other related issues, so that the operation of the project is more efficient and economical. This paper will discuss the role of BIM technology in depth, and explore the advantages and disadvantages of each link through the research of the project, to provide a reference for the promotion of this new project. By constantly adjusting the application strategy, the goal is to meet the current market demand.
The Design of Multi-Connector IoT Central Gateway Based on Raspberry Pi and Docker
Authors: Wang Jie
Published: October 2024

With the vigorous development of Internet of Things (IoT) technology, the demand for communication and data exchange between different types of IoT devices is increasing day by day. To solve the problems of diversity and complexity of communication protocols between devices, this paper proposes a design scheme of a multi-connector IoT central gateway based on Raspberry Pi and Docker. Through the research and application of related technologies, by integrating multiple communication interfaces and utilizing containerization technology, an efficient, flexible, and scalable IoT central gateway has been realized, which can support the connection and data interaction of multiple communication protocols and provide strong support for the stable operation and development of the IoT system.