bluuebunny/crossref_metadata_2025 huggingface dataset:
Number of passes in mechanical thrombectomy: where is your limit?
Authors: Filioglo A. , Cohen J.E. , Simaan N. , Honig A. , Leker R.R.
Published: December 2020

Background and aims. Stent retriever based thrombectomy is the mainstay of treatment of acute ischemic stroke caused by large vessel occlusion. However, recanalization is sometimes not achieved even after multiple passes of the thrombectomy device. Whether revascularization becomes futile or harmful with an increasing number of passes as well as criteria for when to halt attempting recanalization remain unknown. The purpose of our work is to analyze literature data on this issue. Materials and methods. We performed a short review of the literature and summarized evidence on the impact of repeated stentriever attempts on outcome.Results. Despite some controversies, the published data indicate that up to 30 % of patients still reach favorable outcome even when ≥5 stentriever passes are performed. Probability of obtaining functional independence after multiple stentriever attempts is even higher in patients with lower baseline NIHSS score. Patients who achieve successful reperfusion after ≥5 passes have significantly higher rates of functional independence and significantly lower rates of hemorrhagic transformation compared with those who do not achieve reperfusion. Rate of target recanalization after ≥4 passes may reach 19 %. Number of passes alone is not an independent negative predictor of functional independence. The impact of multiple stentriever attempts on hemorrhagic transformation has not been well-established.Conclusions. Target vessel recanalization is an essential goal of mechanical thrombectomy, which should be pursued despite the additional number of passes and procedural time required. Number of stentriver attempts is not a game- changing factor in the decision to abort the procedure for technical futility. Treatment decisions need to be individualized for each patient based on operator’s experience and preferences, patient and clot-specific characteristics.
Quality control approach for civil engineering construction
Authors: Su Danyang , Li Meng
Published: December 2020

Abstract: In recent years, along with the continuous development and progress of society, the process of urbanization has been accelerating. At the same time, the scale of production of construction companies has also been continuously expanded. Civil engineering is an important component of construction engineering. The quality of civil engineering construction directly affects the image and development of construction companies. Therefore, we should focus on strengthening the control of the quality of civil engineering construction to ensure that the company is moving in a better direction. The author explores and analyzes the main factors affecting the construction quality of civil engineering, and puts forward an effective way to control the quality of civil engineering construction to improve the construction quality of civil engineering.
Evaluation Of Urban Park Design Criteria In The Case Of Taraqi Park (Afghanistan, Herat)
Authors: Mohandespor Samira , Yücel Caymaz Gökçen Firdevs
Published: December 2020

The objective of this study is toÂ define park design standards, determine the user expectations of the parks and evaluate the defined standards in the case of Taraqi Park in Herat city.Â On-site detection, observation and survey methods were utilized in the study.Â The conformity of the park area with international standards was evaluated while general satisfaction as to the park was tried to be determined by virtue of surveys made with the users of the park.
Inheritance and Evolution of the Spatial Form of Traditional Rural Settlement
Authors: Li Lianying , Xu Dawei , Chen Xi , Fadelelseed Safa
Published: December 2020

As early as the farming era, traditional rural settlements have been deeply rooted in our country. The geographical location of rural settlements is inextricably linked to the natural environment, transportation and social forms. China has continuously increased its modernization and transformed rural settlements with the rapid development of society, which has led to the change in the spatial form of rural settlements and led to the demise of many traditional settlements. Therefore, the culture and traditions are inevitably deplorable. Settlement is the most primitive way of living in China. Therefore, it is necessary to understand and learn the culture as well as correctly transform the rural settlement. This paper aims to study the spatial form of traditional rural settlements. Based on the background research of traditional rural settlement spatial form, this paper discusses the influencing factors of settlement spatial form and the spatial form and evolution of rural settlements.
Effect of High-Stress Equal Amplitude Cyclic Loading on Mechanical and Deformation Characteristics of Rubber Concrete
Authors: Huang Xin , Chen Yu
Published: December 2020

In order to study the mechanical and deformation characteristics of rubber concrete under repeated loading, 50 cycles of high-stress equal amplitude cyclic loading and uniaxial compression tests were carried out on 30 concrete specimens of 5 groups. The change of uniaxial mechanical properties and the deformation during cyclic loading of normal concrete (NC) and rubber concrete (RC) with 5%, 10%, 15%, and 20% content were analysed. The results show that the peak stress and modulus of elasticity decrease and the peak strain increases with the increase of rubber content. After cyclic loading, the degradation degree of NC peak stress and elastic modulus reached 11.0% and 36.8% respectively. This study can provide a basis for the application of rubber concrete.
Comparative study on characteristics and development of Chinese and western architectural culture
Authors: Mu Kexin , Zhang Chang , Ji Jing
Published: December 2020

Architecture is an indispensable part of the development of human civilization and the carrier of human civilization. The evolution of architectural style can also reflect the development of a nation. With the continuous development of history, the preservation and development of historic sites has gradually become a topic of common concern in China and the west. However, with the continuous development of modern technology, there are fewer and fewer traditional cultural elements in the newly-built buildings, which lead to the gradual loss of some traditional architectural culture. In order to avoid the further aggravation of this phenomenon, something should be done. From the perspective of the development characteristics of Chinese and western architectural culture, the characteristics and differences of the development process of Chinese and western architecture were listed from ancient to modern times, and gradually the main reasons for the different development directions and characteristics were analyzed. In addition, according to the law and characteristics of the development of Chinese and western architecture, some methods on how to solve the inheritance of Chinese modern architecture to traditional culture were put forward.
An Empirical Study on Hainan Citizens' Participation in Urban Community Governance under the Background of Free Trade Port Construction
Authors: Zhou Yuanyuan
Published: December 2020

Hainan is in the period of high-speed development and transformation of government management. To build a free trade port with Chinese characteristics requires a modern social governance system that confirms to the trend of the times, and community governance is important part of whole social governance system. Citizens' cooperative participation in grass-roots community governance has the functions of creating a good living environment, reducing social conflicts, improving residents' sense of well-being and attracting all kinds of talents. Based on the perspective of multi cooperative social governance, this paper empirically investigates the current situation of Hainan urban resident's participation in community governance, explores the reasons for the lack of citizen participation in community governance, and puts forward suggestions for improving citizen participation in community governance.
Numerical Analysis on the Seismic Performance of Plane Irregular Structure Based on ABAQUS
Authors: Zong Lina , Xu Feng , Yuan Wei , Ji Xiaolei
Published: December 2020

Rod element and shell element were used in finite element software ABAQUS to establish dynamic elastic-plastic analysis model of the structure, the seismic performance of an irregular plane complex overrun structure numerical simulation, the structure was calculated under different input level and displacement response of the acceleration response, and analyses the force of the wear layer column and the floor of the open hole stress level. The results were compared with the shaking table test to verify the accuracy of the numerical simulation results. The results of numerical calculation were basically consistent with the experimental results, and the finite element model basically reflected the response of the structure under the simulated earthquake.
Research on Information Security Technology of Online Insurance System Based on WEB
Authors: Zhang QingFeng
Published: December 2020

Abstract:Â With the continuous development and advancement of science and technology, WEB-based online insurance system has become an inevitable choice to adapt to the development trend of the times. On the basis of establishing a system, it is necessary to manage the safe operation structure, thus effectively establishing a complete supervision and maintenance. The system ensures that the management level of insured information security technology can be optimized. This paper briefly analyzes the framework of WEB-based online insurance system, and discusses the security mode and system implementation.
Simple and Multi-layered Quantum dot in various structures
Authors: Mitra Manu
Published: December 2020

Abstract: Quantum dots have interesting optical properties. They absorb incoming light of one color and emit out light of a completely different color. This research paper discloses eigen states of a simple and multilayer quantum dot in various structures for cuboid, cylinder, dome, cone, and pyramid, and its three-dimensional wave function, energy states, light and dark transitions (X-polarized), light and dark transitions (Y-polarized), light and dark transitions (Zpolarized), light and dark transitions (phi = 0 and theta= 45), absorption (phi = 0 and theta = 45), absorption sweep of angle theta, and integrated absorption are plotted and the observations of high peak values are noted and documented.
Distributed Algorithms for MaximizingLifetime in Clustered Wireless SensorNetworks Using Energy-Harvesting RelayNod
Authors: Zhang Pengfei , Tan Hwee-Pink , Xiao Gaoxi
Published: December 2020

Motivated by recent developments in Wireless Sensor Networks(WSNs), we present distributed clustering algorithms for maximizingthe lifetime of WSNs, i.e., the duration till the first node dies. Westudy the joint problem of prolonging network lifetime by introducing clustering techniques and energy-harvesting (EH) nodes. Firstlywe propose distributed clustering algorithm for maximizing the lifetime of clustered WSN, which includes EH nodes, serving as relaynodes for cluster heads (CHs). Secondly graph-based and LP-basedEH-CH matching algorithms are proposed which serve as benchmarkalgorithms. Extensive simulation results show that the proposed algorithms can achieve optimal or suboptimal solutions efficiently
An Examination on the Support of Library Information to the Construction of National Research Organizations
Authors: Wang Hao
Published: December 2020

The country's economic development determines the political and cultural status. At the present time, China's rapid economic development has greatly improved the country’s international prominence. Although China has high economic and political achievements, China's cultural soft power is still in a weak position. Cultural soft power is of great significance in improving the country's overall national strength and international competitiveness. Research organizations are an important part of the country's soft power and are of great significance to the strengthening of national soft power. Research organizations are the “peripheral brain” in the decision-making process of the government. National government agencies need democratic science in making decisions, and the adopted policy methods must have positive and effective outcomes on the people. Therefore, the national government agencies cannot achieve this without the help of research organizations. This resulted in the development and rising construction of research organizations. With the comprehensive development and construction of research organizations, whilst making progress, has also exposed several shortcomings. The construction of China’s research organizations requires various supports; especially the intelligence agencies and access to library information, which has a unique advantage in promoting the construction of research organizations [1]. This paper first introduces the definition, classification and characteristics of a research organization. It will also provide a preliminary understanding of research organizations. The paper will then highlight and analyze the problems encountered by the research organization. Finally, through the grasp of the advantages of the library and intelligence agencies, a solution is proposed.
Local High-Frequency Heating in Electronics Technology
Authors: Lanin Vladimir Leonid
Published: December 2020

Modeling and investigation of HF electromagnetic heating in induction devices with unclosed magnetic circuit has allowed to optimize heating speed in local zones of formation of soldering connections and to improve their quality due to joint action of superficial effects and electromagnetic forces. For all magnetic materials is nonlinear decrease in heating power depending on frequency of HF. Installed the optimal parameters of HF heating for soldering electronics modules by inductor with open-ended magnetic conductor.
Game as a Marketing Tool of Library
Authors: Ge Donglin
Published: December 2020

As a valuable means to attract users, there are not many game service cases in China, and only a few of previous studies on game program as marketing tools. Based on the method of literature research, we studied several cases and try to analyze how American libraries use game program to marketing themselves at three levels, in order to provide some advice for libraries that need to reach more patrons.
A New Method for Pedestrian Detection with Lightweight Backbone based on Yolov3 Network
Authors: Dong Qirui
Published: December 2020

The main purpose of YOLOv3, aiming to improve the detection speed and accuracy from current detection models, is to predict the center coordinates of (x, y) from the Bounding Box and its length, width through multiple layers of VGG Convolutional Neural Network (VGG-CNN) and uses the Darknet lightweight framework to process images at a faster speed. More specifically, our model has been reduced part of YOLOv3’s complex and computationally intensive procedures and improved its algorithms to maintain the efficiency and accuracy of object detection. By this method, it performs a higher quality on mass object detection tasks with fewer detection errors.
Method of the Mission Planning for the Communication between the Small Satellite Clusters
Authors: Yao Duoduo
Published: December 2020

Mission planning of space astronomical satellite is a complex optimization problem, which is to determine the communication activities needed by space astronomical and research the in-orbit plan. By abstracting the relevant elements of the mission planning problems of space astronomical satellite and establishing the mathematical model of mission planning of the space astronomical satellite, we introduce the Genetic Algorithm and design the single-objective Genetic Algorithm based on the communication mission window. In addition, based on the Genetic Algorithm, a multi-objective Genetic Algorithm based on the sequence of communication window is designed, which improves the coding ability of Genetic Algorithm and improves the flexibility and applicability of planning effect. From the results of planning simulation, this paper not only innovatively introduces Genetic Algorithm into mission planning of satellite and ground data in order to improve the efficiency of mission planning of space astronomical satellite, but also optimizes single-objective mission to multi-objective mission, which improves the applicability of mission planning of satellite communication and provides reference for other relevant researches in the future.
Voice Interaction System for Race Games
Authors: Liang Xuanning
Published: December 2020

With the advancement of the computer technology, there are now various kinds of computer games, especially race games (RAC). However, there are still many issues in race games. The first problem is that the interactivity is not fully-fledged. Information can only be input to the computers by manipulators without any feedback from the computers. The second problem is that players cannot pay attention to the information about the road conditions while they are driving. The main reason is that the monitor is usually too small to show the 3-D(three-dimensional) scenes of the game and it is hard for players to notice the road conditions. In order to figure out these problems, we designed a voice interaction system to improve the game experience.

In the future, this technique will have a bright prospect. On one hand, this invention can be applied to VR games which will be one of the most popular research directions. While on the other hand, this invention can also be applied to automatic drive which will definitely change people’s daily life.
Classify mental states from EEG signal using XGBoost algorithm
Authors: Wang Yihao
Published: December 2020

Brain-computer interface (BCI) is a leading-edge technique which allows the brain communicates with external devices. It has been applied in several fields, such as medical rehabilitation, virtual reality and so on. This invention introduces a technique that can be applied in education field to monitor and analyze users’ electroencephalogram (EEG) so that the mental states could be identified. The algorithm of classifier used XGBoost which combined Bayes, KNN and SVM in it and its accuracy could reach to 80%. By using this technique, teacher could obtain the concentration status of students in real time and adjust his or her teaching method or remind the student who is wandering.
Research on OPC-based Fracturing Unit Control System
Authors: Jiang Yiran , Wu Hui
Published: December 2020

With the large-scale integration of fracturing unit's on-site construction, traditional industrial buses are increasingly unable to meet the requirements for the quantity transmission between various equipment in large-scale fracturing units, and different models of different equipment manufacturers cannot cooperate with each other as there are "Islands of information" in the control system. This article uses industrial Ethernet as the physical medium for data transmission. In addition, different equipment manufacturers use OPC as the core technology of the fracturing unit control system network, and set up an intelligent fracturing unit control system, so that the control network can quickly, accurately, and safely control the fracturing truck control system. The sand truck control system monitors and analyzes, saves, and prints the construction data in the vehicle instrument. At the same time, the network control system uses the vehicle instrument as the core of the network. It can control fracturing vehicles from different manufacturers. The sand mixer truck performs network control, which effectively avoids incompatibilities between various equipment manufacturers at the construction site.
Application of Modern Communication Technology in Water Conservancy Work
Authors: Wang Yuming
Published: December 2020

The role of communication is very important in the process of flood prevention work. Modern communication technology can transmit information effectively and implement the communication target of dispatching instructions. Today, the communication technology covers various types such as mobile communication, satellite communication, short-wave communication, optical fiber communication and digital microwave communication. These modern communication technologies are widely used in transmission of information during the process of domestic flood prevention and water conditions. This article focuses on the research of using modern communication technology as the main objective and its specific application in water conservancy work.
Discussion on Crack Control in Road Bridge Design and Construction
Authors: Wan Meng
Published: December 2020

In recent years, China's social economy is in a period of rapid development which has also made great progress in the construction of roads and bridges. Roads and bridges as basic building facilities provides strong support for local transportation and socio-economic development in China. At this stage, roads and bridges are the basic guarantee for the development of the national economy, so great attention must be paid to the quality of their construction and engineering design. At present, the main factor affecting the quality of road bridges in China is the problem of bridge cracks. There are various reasons causes for cracks they must be controlled by effective measures to better improve the quality of road bridges. This article will discuss crack control in road bridge design and construction.
Based on the water source heat pump system operation control and energy consumption optimization
Authors: Wang Guangxiang , Ding Wei
Published: December 2020

The contradiction between the increasing material demand and resource, is the country has faced problems, to better solve the material demand and the contradiction between the environment and resources, is applied to the development of new energy, new energy, not only can alleviate people and resources, environment and resources, the contradiction between people and the environment, also can promote the sustainable development of world economy, HVAC technology has emerged a new generation of energy-saving technology, HVAC has the characteristics of low consumption, low pollution, is a development of technology, to be promoted for environment-friendly, resource-conserving society has an important role in promoting. This paper focuses on the HVAC technology, water source heat pump system operation control and energy consumption optimization, for the relevant personnel reference.
Ecological Relationship between Vascular Plants and Crusts after Sand Fixation Project in Desert
Authors: Chen Zhimei
Published: December 2020

Abstract: In order to understand more about the relationship between vascular plants and crusts after the biological sand fixation project, the vascular plants, composition, coverage and composition changes of crusts in artificial sand fixation vegetation area in Shapotou are studied by quadrat survey method. It is found that the height and coverage of shrubs will decrease with the increase of years after the sand fixation project until reaching a balanced state. The number and height of herbaceous plants will increase in the same period of time, and the thickness of crusts will also increase continuously. According to the water storage property of crusts, when the number of years increases, the thicker the crusts are, the more shrubs will be provided with growth conditions. In addition, shrub roots directly affect biological sand fixation ability, so this paper studies the ecological relationship between vascular plants and crusts after the desert sand fixation project, providing reference for more effective sand fixation work.
The Application of Dynamic Shock Mechanics Test in Engineering Blasting
Authors: Cheng Lin , Liu Junfeng
Published: December 2020

With the continuous advancement of China's infrastructure construction to the west, according to the geographic situation in the southwest region, such as mountainous areas and complex terrain, the road construction process is inevitably accompanied by earth and rock blasting. To improve the quality and safety of the project, this paper addresses the problems of land and rock blasting faced in the construction of mountain road projects, taking the research of rock dynamic mechanics test as the starting point, and using a combination of theoretical analysis and experimental research methods. The specific research content includes the following parts: dynamic impact compression test (SHPB), dynamic splitting tensile test, and stress-strain curve analysis of the test results, which provides the theoretical basis and numerical parameters for the numerical simulation of future engineering blasting.
The Value of Apparent Diffusion Coefficient in Differential Diagnosis of Ovarian Cystic Adenoid Tumors
Authors: Sun Lin , Xu Ruirui , Yan Wei , Zhao Meng , Chen Fei
Published: December 2020

Objective: To quantitatively analyze apparent diffusion coefficient (ADC) value of cystic composition and solid composition in ovarian cystadenocarcinoma, borderline cystadenoma and cystadenoma by 3.0T magnetic resonance imaging (MRI), and to investigate its diagnostic and differential diagnostic values in ovarian cystic adenoid tumors. Methods: Retrospective analysis was carried out on 28 patients with ovarian cystic adenoid tumor as confirmed by surgical and pathological examinations. Examination was performed by Siemens 3.0T MRI scanner. Tumor size, margin, composition (cystic or solid), signal characteristic and presence of ascites were observed. Combined with localization using T2WI and diffusion weighted imaging (DWI), ADC value was calculated from ADC mapping using region of interest ROI (the largest surface area of cystic and solid compositions in tumor). Statistical analysis was performed. Results: Among the 28 ovarian tumors, there were 13 cases of cystadenomas (5 serous cystadenomas and 9 mucinous cystadenomas), 4 borderline mucinous cystadenomas and 11 cystadenocarcinoma (9 serous cystadenocarcinoma and 2 mucinous cystadenocarcinoma). There was no significant intragroup difference in ADC values of cystic composition and solid composition in ovarian cystadenoma and cystadenocarcinoma respectively (P>0.05). The ADC value of solid composition between benign cystadenoma and borderline cystadenoma (P<0.05) showed statistically significantly difference. The difference in ADC value of solid composition between benign cystadenoma and cystadenocarcinoma was also statistically significant (P<0.05). There was no significant difference in ADC value of cystic composition between benign cystadenoma, borderline cystadenoma and cystadenocarcinoma (P>0.05). Conclusion: Quantitative analysis of ADC value of solid composition using 3.0T MRI has great value in differential diagnosis of benign and malignant ovarian cystic adenoid tumors. Its combination with conventional MRI method can improve the accuracy of diagnosis of ovarian cystic adenoid tumors.
Clinical Study on Treatment of Vascular Aging in Patients with Type 2 Diabetes Complicated by Hypertension with Combination of Traditional Chinese Medicine and Western Medicine
Authors: Ju Bin
Published: December 2020

Objective: To explore the clinical effect of combination of traditional Chinese medicine and western medicine in treatment of vascular aging in patients with type 2 diabetes complicated by hypertension. Methods: Ninety patients with type 2 diabetes complicated by hypertension admitted to our hospital from May 2016 to August 2019 were selected as research objects. They were randomly divided into control group and observational group, with 45 cases each. Control group was given amlodipine besylate combined with metformin hydrochloride. On the basis of control group, observational group was given combination of TCM syndrome differentiation. Blood glucose, blood pressure and blood lipids before and after 14 days of treatment were compared between two groups. Results: Blood glucose, blood pressure and lipid indexes after treatment were lower than before treatment in both groups; observational group was lower than control group and the difference was statistically significant (P<0.05). Conclusion: Combination of traditional Chinese medicine and Western medicine could lower blood glucose and blood pressure indexes, control blood lipids and delay blood vessel aging in patients with type 2 diabetes complicated by hypertension, it is worthy of clinical popularization.
Observation of the Efficacy of Laparoscopic Resection of Anterior Rectal Cancer in Treating Rectal Cancer
Authors: Zhang Hao
Published: December 2020

Objective: To analyze the efficacy of laparoscopic resection of anterior rectal cancer in treating rectal cancer. Methods: Fifty patients with rectal cancer who were treated in Gucheng County Hospital of Hebei Province from September 2017 to September 2019 were selected and recruited in the present study. These patients were divided into two groups, namely the control group and observation groups, by random number table method. Each group consisted of 25 patients. The control group underwent laparoscopic assisted transanorectal mesorectal excision, whereas the observation group underwent laparoscopic resection of anterior rectal cancer. The two groups were compared for related indicators, indicators pertaining to postoperative recovery, and complications. Results: There was no significant difference in the number of lymph node dissections between the two groups (P>0.05). The amount of intraoperative blood loss, surgical operation time, and incision length in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). The time of getting out of bed, anal exhaust, and duration of hospital stay were shorter in the observation group than those of the control group, and the differences were statistically significant (P<0.05). In addition, the incidence of postoperative complications in the observation group was lower than that in the control group, and the differences were statistically significant (P<0.05). Conclusions: Laparoscopic resection of anterior rectal cancer is effective for rectal cancer patients. This treatment method can effectively reduce the amount of intraoperative bleeding, shorten the operation time, the time of anal exhaust, get out of bed, and the length of hospital stay, as well as improve condition of the patients.
Clinical Effect of Emergency Gastroscopy on Acute Bleeding of Gastric Cancer
Authors: Qi Li , Wang Cong , Wang Jun
Published: December 2020

Objective: To explore the clinical effect of applying emergency gastroscopy in the treatment of patients with acute bleeding of gastric cancer. Methods: A total of 80 patients with upper gastrointestinal bleeding caused by gastric cancer who were admitted in our hospital from December 2018 to December 2019 were selected and recruited. These patients were divided into two groups, namely the control group and experimental group by random number method, and were given conventional drug treatment and emergency gastroscopy treatment respectively. There were 40 patients in each group. The treatment effect and complication rate of the patients in each group were compared. Results: The rate of efficacy of emergency gastroscopy treatment in patients of the experimental group was 95.00%, whereas the rate of efficacy of conventional drug treatment in patients of the control group was 82.50%. The efficacy rate in the experimental group was higher, and the data were significantly different after statistical comparison. Before treatment, the Karnofsky functional status scores of the patients in both control group and experimental group were not significantly different. After treatment, the patients' scores were all improved. Compared with the control group, the experimental group had a higher degree of improvement, and the effect was more significant. There was a statistically significant difference in data between the two groups (P < 0.05). Conclusion: Gastroscopy treatment of patients with acute gastrointestinal bleeding caused by gastric cancer can effectively shorten the bleeding time of patients, reduce the incidence of postoperative complications, and have positive impact for the prognosis of patients.
Quantitative Analysis of Fecal Hemoglobin Concentration in Colorectal Cancer Patients – The Values in the Screening and Diagnosis of Colorectal Cancer
Authors: Wu Manqun
Published: December 2020

Objective: To use immunochemical detection of fecal hemoglobin amount as a technical method, to perform a FIT test on the fecal specimens of research subjects who were going to undergo colonoscopy. The recorded results are compared and analyzed, and the sensitivity and specificity of the detection method in the diagnosis of colorectal cancer were evaluated. Methods: Three hundreds of individuals who were going to undergo colonoscopy were tested for GFOBT and FIT in feces in advance, and 20 ?g/g was used as the threshold for determining positive FIT result. The results were analyzed and compared with the results of colonoscopy. Results: The sensitivity of FIT to the diagnosis of colorectal cancer was 80.95%, and the specificity was 86.54%. The positive predictive values of FIT test in colorectal cancer screening were 53.1% and 81.77%, respectively. Conclusion: FIT is more sensitive and specific for detecting colorectal cancer and adenoma. The fecal occult blood test (FOBT) is stronger, and FIT test detection is more valuable in colon cancer screening.
Effect of 5-hydroxytryptamine Receptor in the Lower Esophageal Sphincter Regulation Mechanism
Authors: Li Hefei , Liu Junfeng , Zhang Xixuan , Lai Zhiwei , Gao Zhen , Song Chuntao
Published: December 2020

As a neurotransmitter and avascular active substance, the 5-hydroxytryptamine (5-HT, serotonin) is widely distributed in the central nervous system and surrounding tissues. The 5-HT can play its role by acting on its corresponding 5-HT receptor. Nowadays, the 5-HT receptor can be classified into seven, according to different signal transduction method of receptors, the 5-HT3 receptor belongs to the ligand-gated ion channels, while other six 5-HT receptors are involved into the G protein-coupled receptors and play the biological role by binding to specific G protein-coupled receptors (GPCRs) on the surface of the cell membrane. The 5-HT plays an important role in the brain-gut information transmission and studies showed that the physiological stimulations like having meals, and pathological stimulations like ischemia and stress could promote the release of the 5-HT. In the gastrointestinal tract, the 5-HT is closely related to gastrointestinal sensitivity, gastrointestinal movement and secretion regulation, as well as many gastrointestinal dysfunction disorders, such as gastrointestinal power and visceral sensitivity abnormality and abnormalities of brain-gut axis.
Effect of Targeted Nursing Based on Basic Living Care on Patients With Chronic Gastric Ulcer
Authors: Hu Xue
Published: December 2020

Objective: To explore the effect of targeted nursing based on basic living care on patients with chronic gastric ulcer. Method: Ninety patients with chronic gastric ulcer treated in our hospital from August 2018 to August 2019 were selected and divided into observation group (n = 45) and control group (n = 45) randomly. The control group was given routine care. On the basis of the control group, the observation group was given targeted care based on basic living care. Compare the compliance behavior in two groups. Results: After the intervention, the compliance score of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: The use of targeted care based on basic living care for patients with chronic gastric ulcer can improve their compliance behavior, which is worthy of clinical application.
The Diagnostic Significance of Ultrasound and Ultrasound-guided Coarse Needle Biopsy in Breast Cancer in Pregnancy
Authors: Jin Jihai , Zheng Dongxing , Gao Xueshan , Lin Guangrong
Published: December 2020

Objective: To explore the significance of ultrasound and ultrasound-guided coarse needle biopsy in the clinical diagnosis of breast cancer patients in pregnancy. Methods: A total of 10 patients with breast cancer in pregnancy were selected to study from October 2018 to October 2019 in our hospital, who were given preoperative ultrasound results and ultrasound-guided coarse-needle biopsy histopathology, and the results were analyzed. Results: All the 10 patients showed thickening of the mammary gland body, appeared to pick up disorderly situation, most of the dilated catheter, including 8 patients with solid hypoechoic mass, irregular shape, and "crab foot" edge burr. The corresponding aspect ratio value was greater than 1. The other 2 patients presented with cystic mixed masses with poor boundary definition, irregular shape, and mostly accompanied by posterior echo enhancement. Conclusion: Simple ultrasound diagnosis for patients with breast cancer during pregnancy has some errors, and should be used in combination with ultrasound-guided coarse needle biopsy operation. This method has a high clinical diagnosis rate and significant clinical application value, so it is worth promoting.
Research Progress of microRNA in Regulating Gynecological Tumours
Authors: Cao Zhiyong , Fang Gang , Ke Lu
Published: December 2020

The incidence of gynaecological tumours, the main factor threatening women ’s health and safety, is increasing with the daily heavier pressure of women’s life and work; Due to its serious threat to women, the disease has grasped increasingly more vigilance and attention. The discovery and research of micro ribonucleic acid (microRNA), a general term for a class of small-molecule RNA, showed that there was a close relationship between microRNA and the occurrence and development of gynaecological tumours. In this paper, based on the recent researches on the relationship between microRNA and gynaecological tumours, a comprehensive analysis was made to do a favour for scientific research and clinical treatment of gynaecological tumours.
Exploring the Management of Stem Cell Research Based on Bioethics
Authors: Jiang Yanming
Published: December 2020

Stem cell research has brought hope to mankind to overcome various diseases, but ethical issues arise in stem cell research, and people have doubts about how to develop stem cell research healthily and whether it can bring the gospel to mankind. Management of stem cell research based on bioethics is extremely necessary. From the perspective of bioethics, the number of research literature is used to analyze the development of stem cell research and the management of stem cell research in China, to provide suggestions for further strengthening the management of stem cell research.
A Randomized Controlled Clinical Study of Irinotecan/cisplatin Regimen and Etoposide/cisplatin Regimen in the First-line Treatment of Small Cell Lung Cancer
Authors: Jiang Bo
Published: December 2020

Objectives: This paper mainly study on the effects of irinotecan/cisplatin and etoposide/cisplatin regimens in the treatment of small cell lung cancer. Methods: 50 cases of small cell lung cancer patients in our hospital were divided into control group and experimental group and administered with etoposide/cisplatin and irinotecan/cisplatin regimen, and the treatment effects of the two regimens were compared statistically. Results: After treatment, both groups achieved high treatment efficiency, and the incidence of toxic side effects was low, with no significant difference (P>0.05)? serological ABCG2 and FGFBP1 level indicators were better than the control group?both showing significant differences (P<0.05). Conclusions?Irinotecan has achieved better improvement in serological indicators in the first-line treatment of small cell lung cancer, with no significant difference in short-term treatment efficiency.
The Expression and Significance of CyclinD2, MPGES-1, Bcl2 in Diffuse Large B-cell Lymphoma
Authors: Ma Qiushuang , Lin Peng , Zhou Bingjuan , Zhao Yafei , Li Ling , Zhang Jinku , Sun Jirui
Published: December 2020

Objectives: To study the expression and significance of cell cycle proteins CyclinD2, mPGES-1, Bcl2 in diffuse large B-cell lymphoma. Methods: Choose lymphoma and sexually hyperplastic lymphoid tissues as control. Immunohistochemical methods were used to detect the expression of CyclinD2, mPGES-1, and Bcl2, and to compare the positive expression rates of CyclinD2, MPGES-1 and Bcl2 in diffuse large B-cell lymphoma and reactive proliferative lymphoid tissues to compare their diffusion formation. B-cell lymphoma was analyzed for its clinicopathological features. Results: The positive expression rate of CyclinD2, mPGES-1 and Bcl2 in diffuse large B-cell lymphoma is higher than that in reactive proliferative lymphoid tissue, and the difference between the two is statistically significant. There was no statistical difference in CyclinD2, mPGES-1 and Bcl2 in diffuse large B-cell lymphoma between patients according to the age, sex, location, tissue type and degree of differentiation. Conclusion: CyclinD2, mPGES-1 and Bcl2 are highly expressed in patients with diffuse large B-cell lymphoma, and can be used as reference indicators for evaluating the malignant degree and efficacy of dysplasia.
Progress in the Pathogenesis and Treatment of Radiation-Induced Brain Injury
Authors: Gao Xiaohan , Wu Xiaohan , Yang Xiaoqian , Chen Shaoshui , Zhi Hongmin
Published: December 2020

Malignant tumors are one of the serious public health problems that threaten the survival time of human beings. They are prone to metastasis to distant organs and the central nervous system is one of the common target organs. As it is difficult for chemotherapeutics, targeted drugs and other macromolecules to pass through the blood brain barrier (BBB), local radiation therapy is often used for treating intracranial primary or metastatic tumors. However, whether it is whole brain radiation therapy (WBRT) or stereotactic body radiation therapy (SBRT), the choice of radiation dose is limited by the side effects of radiation therapy on the surrounding normal brain tissues. Radiation-induced brain injury (RBI) can further develop into radiation necrosis (RN) in the late stage. Bevacizumab is often effective against RBI by antagonizing vascular endothelial growth factor (VEGF), but it still cannot completely reverse RN. Emerging treatment options such as human pluripotent stem-cell transplantation have made it possible to reverse the process of RN.
Current Research Status of Circulating Free DNA in Clinical Application
Authors: Wang Yanjing , Sun Jirui , Zhang Jinku
Published: December 2020

Circulating free DNA (cfDNA) refers to the free DNA nucleotides in body fluids, but the dynamic response in vivo tumor load and full assessment of genetic heterogeneity in cancer patients provides a non-invasive diagnostic approach. It is one of the effective biomarkers for cancer screening and diagnosis, and also provides for the prognosis for patients with advanced cancer and forecast information. In this paper, the clinical application of cfDNA is reviewed.
Comparison of Clinical Effects of Abdominal Aortic Aneurysm Treatment with Open and Endovascular Techniques
Authors: Dou Ning , Tan Jing-jing , Zuo Jian
Published: December 2020

Objective: To compare the therapeutic effects of endovascular and open surgery on abdominal aortic aneurysms.  Methods: From June 2019 to May 2020, 60 cases of abdominal aortic aneurysms (AAA) were divided into observation group (30 cases in endovascular technique group) and control group (30 cases in open technique group). Results: The blood loss, operative time and blood transfusion of the observation group were significantly lower than those of the control group (P<0.05). The incidence of postoperative complications is low, and the incidence of long-term complications is relatively high.  Conclusion: In the treatment of abdominal aortic aneurysm, endovascular technology has the advantages of low risk, less trauma, and quick recovery after surgery. Open surgery is suitable for patients who cannot receive endovascular treatment. In order to achieve good treatment effects, it is necessary to choose an appropriate treatment method according to the actual situation of the patient.
Message from the Editor-in-Chief of IJES Vol. 3(3), 2020
Authors: Melnyk Yu. B.
Published: December 2020

Dear Readers, We are honored to publish the International Journal of Education and Science (IJES), Vol. 3, No. 3, 2020. IJES is an academic periodical peer-reviewed indexed Journal that provides a scientific platform for presenting and discussing new trends and issues in Social and Behavioral Sciences. Since 2018, the Journal has published more than 200 manuscripts, including: Original Research, Review Articles, Brief Reports, Conference Abstracts, Reviews, Letters to the Editor. IJES Editorial Board includes the most authoritative scientists from 14 countries, 5 continents in the fields of Education, Psychology, Economics, Medicine. IJES is presented in 15 international scientometric databases, repositories and search engines: Crossref System, Google Scholar, Kopernio (USA); Publons (New Zealand); Scilit (Switzerland); ROAD (France); Index Copernicus International (Poland), etc. Indexed in the ICI Journals Master List ICV 2019: 80.33. From the second half of 2020, the IJES Editorial Board decided to replace one of the scientific directions of the Journal with another more specialized one (Medicine for Law). This is due, on the one hand, to the need for a certain specialization of the Journal, on the other – allows us to discuss new trends in interdependent areas: Pedagogy – Psychology, Economics – Law, which are included in the Social and Behavioral Sciences. So, from 2021 this international Journal is intended for professionals and researchers in scientific fields: Education, Psychology, Economics, Law. On behalf of the IJES Editorial Board, I personally would like to thank all the members of the Editorial Board who represented the Journal in the field of Medicine during these years. As the Publisher of the IJES, KRPOCH Publishing invited these members of the Editorial Board to continue their cooperation as members of the Editorial Board of the International Journal of Science Annals. IJES provides immediate Open Access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. All Articles apply under the terms of the Creative Commons Attribution License (CC BY 4.0). The Journal publishes Review Articles and Original Research, Letters to the Editor, and Reviews. A total of fourty five manuscripts were submitted for this issue, and each article was subjected to a doubleblind peer review process by reviewers specializing in the relevant field. At the end of the review process, five high quality research papers were selected and accepted for publication in this issue. Accordingly, the purpose of this issue is to enable researchers to share the results of their academic research. The articles discuss various research topics. We would like to thank all the Authors who submitted their manuscripts and to the IJES Editorial Board, which worked on this issue.