bluuebunny/crossref_metadata_2025 huggingface dataset:
Microbiological status of smoked fish placed on the market in Poland
Authors: ZIOMEK MONIKA , SZKUCIK KRZYSZTOF , BEŁKOT ZBIGNIEW , GONDEK MICHAŁ , SKAŁECKI PIOTR , PEDONESE FRANCESCA , KALINIAK-DZIURA AGNIESZKA , OŻGA DOROTA PIETRAS –
Published: September 2023

Fish and fishery products are considered to be one of the most nutrient-rich dietary products. The nutritional value of fish depends on its freshness. The greatest role in fish spoilage is played by microbial decomposition. Smoking is one of the methods of fish preservation based on the action of temperature and the penetration into the tissue of preservative substances produced by burning wood. Almost all microorganisms except some pathogenic bacteria are destroyed in the smoking process; nevertheless, fish can be a source of some pathogenic microorganisms, i.e. Listeria monocytogenes, Salmonella spp., Staphylococcus spp., which are present as the result of cross-contamination at the stage after smoking, i.e. marketing and storage (4, 5, 8). Improper and unhygienic handling practices with the ready-to-eat RTE product are also the cause of an increase of the total microbiological contamination, which can be expressed by microbiological contamination indicators, i.e. total viable count (TVC), psychrophilic bacteria count (PBC), coliform count (EBC), total yeast and mould count (TYMC) and total staphylococci count (TSC). In the performed study five smoked fish species (redfish, mackerel, codfish, sprat and herring) were tested at the marketing stage. A total number of 50 (N = 50) samples was tested according to ISO standards. The potential foodborne bacteria in the tested samples were identified using a MALDI-TOF spectrometer combined with MALDI-Biotyper 3.0 software. In the performed study, the highest microbiology contamination TVC on the level 3.63 ± 0.15 log10 cfu/g and PBC on the level 3.04 ± 0.24 log10 cfu/g has been found in redfish muscle compared to herring, codfish, sprat and mackerel muscle. A significantly lower amount of 1.26 ± 0.12 log10 cfu/g yeast and moulds of was found in the muscle tissue of herring, compared to the other tested fish. The highest staphylococcal contamination of muscle tissue of redfish on the level 2.56 ± 0.15 log10 cfu/g and mackerel on the level 2.13 ± 0.15 log10 cfu/g was found. MALDI-TOF identification of isolated bacteria not confirmed the presence of Salmonella spp., Listeria monocytogenes and pathogenic Staphylococci and confirmed the presence of E. coli in tested redfish.
Thermodynamic performance assessment of a community-scale brackish water reverse osmosis plant using exergy analysis
Authors: Sutariya Bhaumik , Amaliar Govind
Published: September 2023

This study investigated the thermodynamic performance of a community-scale membrane-based brackish water reverse osmosis (BWRO) plant at various operating pressures from 13.79 to 27.58 bar and feed salinity levels from 2,000 to 20,000 mg/L. We aimed to identify the components responsible for the exergy losses and to suggest improvements. The results showed that the exergetic efficiency of some individual components had a significant impact on the performance of the desalination plant, where the high-pressure (HP) pump assembly and pressure control valve were identified as the major contributors to exergy losses (57.83–70.59 and 15.75–27.62%, respectively). The inefficiency of the feed pump assembly contributed to 11–12% of the total destruction of exergy under different operating conditions. The analysis further revealed that the exergetic efficiency of the plant was maximum (0.51%) at the feed salinity of 10,000 mg/L and operating pressure of 27.58 bar. It was minimum (0.01%) for the highest salinity (20,000 mg/L) and the lowest operating pressure (13.79 bar), due to the low requirement of work of separation and higher fixed losses. The exergetic efficiency was also correlated to the energetic performance of the BWRO plant at different operating conditions.
18F-fluorodeoxyglucose positron emission tomography/computed tomography findings of breast cancer with signet ring cell differentiation: A single-center experience
Authors: ALÇIN Göksel , ARSLAN Esra
Published: September 2023

Aim: Due to the low incidence of breast cancer with signet ring cell (SRC) differentiation, which constitutes less than 1% of all breast cancers, little is known about its imaging features. The aim of this study was to evaluate the utility of 18F-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography/Computed Tomography (PET/CT) in staging breast cancer with SRC differentiation.

Methods: We conducted a retrospective analysis of 14 patients with histologically confirmed breast cancer with SRC differentiation who underwent 18F-FDG PET/CT at our institution between 2014 and 2023. The imaging findings were analyzed in terms of maximum standardized uptake value (SUVmax), lesion size, and the presence of regional or distant metastases were statistically evaluated.

Results: The histological subtypes of SRC differentiated primary tumors were 9 invasive lobular, and 5 invasive ductal carcinoma. More intense 18F-FDG uptake was observed in primary tumoral lesions of the ductal subtype (mean SUVmax: 18.8±9.8; range: 2.6–28.9) compared to the lobular subtype (mean SUVmax: 2.6±1.3; range: 1.5–5.1) (p=0.007, Z=2.600). Among the patients included in the study, axillary lymph node metastasis was present in 64% (n=9) of the cases, with lymph node metastasis identified in five cases classified as ductal carcinoma. Additionally, distant organ metastasis was identified in 21% (n=3) of patients, comprising two patients with ductal carcinoma and one with lobular carcinoma.

Conclusion: Despite the general consensus that signet-ring cell tumors have a low affinity for 18F-FDG, our study has observed the possibility of high 18F-FDG uptake in cases of ductal carcinoma. However, in cases of lobular carcinoma, where 18F-FDG uptake tends to be low, considering alternative PET radiopharmaceuticals for imaging could be a viable option.
Elektif cerrahiler ve girişimsel prosedürler öncesi preoperatif hazırlıkta COVID-19 real time polimeraz zincir reaksiyonu için sürüntü sonuçlarının analizi: Retrospektif çalışma
Authors: ÇALIM Muhittin , TELOĞLU Emine Şeyda , UYSAL Harun , SÜMBÜL Bilge , ESEN Asım
Published: September 2023

Amaç: Bu retrospektif kohort çalışmada, bir üniversite hastanesinde preoperatif hasta popülasyonunun Coronavirus Disease 2019 (COVID-19) testi pozitifliğinin oranının belirlenmesi ve preoperatif COVID-19 pozitif hasta sayısı ile demografik özelliklerin, operasyona özgü bulguların ve özellikle kan grupları ile ilişkisinin ortaya konması amaçlanmıştır.

Yöntemler: Bu retrospektif kohort tek merkezli çalışma, üniversite hastanesinde gerçekleştirildi. Çalışmaya Haziran 2020 ile Nisan 2021 tarihleri arasında farklı cerrahi branşlarda elektif cerrahi planlanan ve preoperatif COVID-19 taraması yapılan tüm yetişkin hastalar dahil edildi. Hastaların demografik özellikleri, operasyona özgü bulguları ve kan grupları incelendi.

Bulgular: COVID-19 pozitif grubuna ait hastaların yaşı COVID-19 negatif grubuna göre anlamlı olarak daha yüksek idi (50,20±18,3, 47,27±17,28, sırasıyla, p=0,030). COVID-19 pozitif grubuna ait ASA fiziksel durum sınıflamasında skoru yüksek hastalar anlamlı olarak daha fazla idi (p
Explorando valores organizacionais por meio de símbolos
Authors: Silva Marcelo Ribeiro , Fonseca Leticia Rodrigues da , Silva Sheldon William , Pereira Guilherme Marques
Published: September 2023

O objetivo deste artigo é identificar valores subjacentes organizacionais por meio de análise simbólica em um moinho de trigo. A perspectiva teórica de Thomas e Znaniecki, da Escola de Chicago, fundamenta a análise juntamente com a teoria de Edgard Schein sobre cultura organizacional. Portanto, valores podem ser anunciados nos símbolos, sejam eles objetos concretos ou abstratos, tais como o ambiente arquitetônico da organização, o layout, a vestimenta dos funcionários, os padrões de comportamento visíveis, entre outros. Do ponto de vista metodológico, a pesquisa classifica-se como um estudo de caso qualitativo, em que o pesquisador visa compreender o fenômeno sob o prisma das perspectivas dos pesquisados. A coleta de dados envolveu técnicas de entrevista, observação não participante e análise documental. Os resultados demonstraram que valores de (i) trabalho árduo, honestidade e poupança; (ii) conservadorismo; (iii) coesão social e (iv) humildade se destacam como critérios de orientação do comportamento dos indivíduos na organização.
digitalização do mercado de crédito brasileiro:
Authors: Fazio Renata Mendonça de , Santos José Odálio dos , Borelli Elizabeth
Published: September 2023

Com a digitalização do mercado de Crédito brasileiro, impulsionado pelo Open Banking e pelas resoluções n. 4.656 e n. 4.657/2018, o consumidor tem mais acesso a crédito em diversos canais de contratação além das agências físicas. O presente estudo tem como objetivo identificar fatores que impactam a decisão do consumidor por canais físicos ou digitais para a contratação de um empréstimo. Para atingir esse objetivo, foi desenvolvido e aplicado questionário, que obteve 498 respondentes. A pesquisa aborda as taxas de juros, a percepção de segurança no ambiente bancário digital, a idade do cliente e a aceitação de inovação como fatores que influenciam a escolha. Observa-se que o relacionamento satisfatório com a instituição impacta a escolha de clientes de instituições tradicionais, porém não impacta para clientes de instituições não tradicionais. A contribuição deste estudo é trazer um enfoque do produto empréstimo para a discussão de aceitação do canal digital, bem como trazer uma aplicação à realidade brasileira sobre esse tema.
Innovative Genoceuticals in Human Gene Therapy Solutions: Challenges
and Safe Clinical Trials of Orphan Gene Therapy Products
Authors: Sharma Rakesh
Published: September 2023

The success of gene therapy attempts is controversial and inconclusive. Currently, it is
popular among the public, the scientific community, and manufacturers of Gene Therapy Medical
Products. In the absence of any remedy or treatment options available for untreatable inborn
metabolic orphan or genetic diseases, cancer, or brain diseases, gene therapy treatment by genoceuticals
and T-cells for gene editing and recovery remains the preferred choice as the last hope. A
new concept of “Genoceutical Gene Therapy” by using orphan ‘nucleic acid-based therapy’ aims
to introduce scientific principles of treating acquired tissue damage and rare diseases. These Orphan
Genoceuticals provide new scope for the ‘genodrug’ development and evaluation of genoceuticals
and gene products for ideal ‘gene therapy’ use in humans with marketing authorization application
(MAA). This perspective study focuses on the quality control, safety, and efficacy requirements
of using ‘nucleic acid-based and human cell-based new gene therapy’ genoceutical products
to set scientific advice on genoceutical-based ‘orphan genodrug’ design for clinical trials as per
Western and European guidelines. The ethical Western FDA and European EMA guidelines
suggest stringent legal and technical requirements on genoceutical medical products or orphan genodrug
use for other countries to frame their own guidelines. The introduction section proposes less--
known ‘orphan drug-like’ properties of modified RNA/DNA, human cell origin gene therapy medical
products, and their transgene products. The clinical trial section explores the genoceutical
sources, FDA/EMA approvals for genoceutical efficacy criteria with challenges, and ethical guidelines
relating to gene therapy of specific rare metabolic, cancer and neurological diseases. The safety
evaluation of approved genoceuticals or orphan drugs is highlighted with basic principles and
‘genovigilance’ requirements (to observe any adverse effects, side effects, developed signs/symptoms)
to establish their therapeutic use. Current European Union and Food and Drug Administration
guidelines continuously administer fast-track regulatory legal framework from time to time,
and they monitor the success of gene therapy medical product efficacy and safety. Moreover, new
ethical guidelines on ‘orphan drug-like genoceuticals’ are updated for biodistribution of the vector,
genokinetics studies of the transgene product, requirements for efficacy studies in industries for
market authorization, and clinical safety endpoints with their specific concerns in clinical trials or
public use.
Therapeutic Potential and Pharmacological Activities of Moscatilin in
Medicine for the Treatment of Cancers and other Human Complication: A
Review of the Active Components of Dendrobium Species
Authors: Patel Dinesh Kumar
Published: September 2023

Background:

Plant-derived byproducts have been used to treat numerous kinds of human
complications in medicine since a very early age. Moscatilin is a bibenzyl compound found to be present
in Dendrobium. Moscatilin, also called 4,4′-dihydroxyl-3,3′,5-trimethoxybibenzyl has potential
benefits in medicine for the treatment of ovarian, lung, breast, esophageal, hepatic, colorectal, pancreatic
and neck squamous cancer.

Methods:

The present work summarized the health-beneficial aspects of moscatilin for its effectiveness
against numerous kinds of cancerous disorders in medicine. Pharmacological activities and analytical
aspects of moscatilin have been analyzed in the present work through available scientific data
on Google, Scopus, Science Direct, and PubMed.

Results:

Scientific data analysis of moscatilin signified their therapeutic effectiveness against ovarian
cancer, lung cancer, breast cancer, esophageal cancer, hepatic cancer, colorectal cancer, pancreatic
cancer, neck squamous cell cancer, apoptosis, and angiogenesis. Further, moscatilin has a significant
effect on inflammation, Alzheimer's disease, diabetic neuropathy, and retinal ischemia. However,
analytical data on moscatilin were also discussed in the present work in order to know the effective
separation, isolation and identification of moscatilin.

Conclusion:

Scientific information on moscatilin presented in this work will be helpful to all
scientific people to understand the biological importance and therapeutic potential of moscatilin in
medicine.
Why do some Children Get Sick with Recurrent Respiratory Infections?
Authors: Cardinale Fabio , La Torre Francesco , Tricarico Lucia Grazia , Verriello Giuseppe , Mastrorilli Carla
Published: September 2023

Respiratory tract infections (RTI) represent a frequent condition, particularly among
preschool children, with an important burden on the affected children and their families. It has
been estimated that recurrent RTIs affect up to 25% of children during the first 4 years of life. Th-
ese infections are mainly caused by viruses and are generally self-limiting. Social and environmen-
tal factors have been studied in determining the incidence of recurrent RTIs and the mostly recog-
nized are precocious day care attendance, tobacco exposure and pollution. Primary immune de-
fects, local anatomical factors, and genetic disorders such as primary ciliary dyskinesia or cystic fi-
brosis, may be also involved in recurrent RTIs of a subgroup of children, typically characterized by
more severe and chronic symptoms. However, there is increasing awareness that RTIs have a com-
plex pathophysiology and that some underrecognized factors, including genetic susceptibility to in-
fections, low levels of some micronutrients, and respiratory microbiota might shape the probability
for the child to develop RTIs. The sum (i.e. the number) of these factors may help in explaining
why some children get sick for RTIs whilst other not. In some children iatrogenic factors, includ-
ing improper use of antibiotics and NSAIDS or glucocorticoids might also aggravate this condi-
tion, further weakening the host's immune response and the possibly of establishing a “vicious cir-
cle”. The present review aims to focus on several possible factors involved in influencing RTIs and
to propose a unifying hypothesis on pathophysiological mechanisms of unexplained recurrent RTIs
in children.
Reactive Arthritis in Children: Case Report, Narrative Review and
Proposed Therapy
Authors: Alshaya Milad , Almutairi Nouf , Alrasheed Abdulrahman , Albanaqi Ihtifal , Laxer Ronald M. , Alhammad Abdullah
Published: September 2023

Reactive arthritis is an acute inflammatory aseptic arthritis that is preceded by an infectious
process in genetically predisposed individuals. It has been associated with gastrointestinal or
genitourinary infection. Reactive arthritis is rare in children. In this review, we present two index
cases that need biologic treatment followed by a thorough review of reactive arthritis in children
and adolescents with proposed treatment algorithm.
Current Challenges and Issues in Indian Regulations of Medical Devices
Authors: Bhatia Rohit , Singh Shubham , Parashar Ananya , Thakkar Arti R.
Published: September 2023

The study's objectives are to highlight the significance of medical devices, investigate the
prospective expansion of the Indian market, look at the legislative changes made possible by MDR
2020, and deal with the ongoing issues with cost, quality, and adverse responses. The research aims to
enhance the Indian medical devices sector by offering insightful observations and suggestions. This
study intends to highlight the significance of medical devices, assess the prospective growth of the Indian
industry, look at the regulatory changes brought about by MDR 2020, and address the ongoing
issues with cost, quality, and adverse responses. The goal of the research is to help the Indian medical
devices business grow by offering helpful insights and practical suggestions. The improvement of
people's well-being and health depends heavily on medical technologies. The usage of medical devices
is expected to rise as technology develops and illnesses spread. The Indian medical device industry
is expected to grow to a market value of USD 50 billion by 2025, placing it fourth in Asia. The "Atma
Nibbar Bharat" strategy, which emphasizes independence, is anticipated to support the expansion of
India's medical device industry. Before the passage of the Medications and Cosmetics Act of 1940,
there were no explicit regulations controlling medical devices, which resulted in their designation as
medications. The Medical Device Regulation (MDR) was initially announced in 2017, nevertheless,
and went into effect in January 2018. The Indian medical device sector was greatly impacted by the
change of this guideline paper into MDR 2020. For testing and altering equipment that comes within
the new criteria, the amended legislation offers a wider range of options. Despite these positive adjustments,
problems still exist. Significant drawbacks include unregulated pricing, difficulties with
quality control, and negative responses to medical equipment. This essay covers these topics in extensive
detail and includes pertinent advice. It is stated which department is in control of handling these
issues. To successfully address these issues, thorough examples, case studies, and solutions are given.
In conclusion, this abstract emphasizes the significance of medical devices, the market's potential for
growth in India, MDR 2020's legislative adjustments, as well as the ongoing difficulties related to
cost, quality, and bad responses. The essay seeks to solve these problems by providing insightful analysis
and suggestions.
Glucocorticoids, COVID-19 and Cryptococcosis
Authors: dos Santos Wanessa Maria , Rogerio Alexandre Paula
Published: September 2023

Cryptococcus neoformans and C. gattii pneumonitis could persist asymptomatically for indefinite periods, resolve, or progress to symptomatic dissemination, mainly in immunocompromised individuals (e.g., treated with corticosteroids). The symptoms of COVID 19 may range from a self limiting illness with general symptoms, such as fever, to more severe complications, such as pneumonitis. The glucocorticoids emerged as potential for treatment of COVID 19, mainly those patients who required ventilator therapy. However, although treatment with glucocorticoids has shown benefits in patients with COVID 19, they can be dangerous due to increased risk of co
infections and superinfections caused by opportunistic pathogens such as Cryptococcus ssp. Some patients with severe COVID 19 pneumonia treated with glucocorticoids developed cryptococcal infection and died. Therefore, immunomodulatory therapy could increase the susceptibility to acute infection or reactivation of Cryptococcus ssp in COVID 19 patients, and this could be complicated once pulmonary cryptococcosis has symptoms similar to COVID 19 becomes difficult to distinguish between the two disease states and treatment.
Proniosomes Nanoparticle for the Treatment of Peripheral Arterial Disease
Authors: Panchal Preyash A. , Patel Shruti , Patel Asha , Ahlawat Priyanka
Published: September 2023

Background:

The common symptom of systemic atherosclerosis is peripheral arterial disease (PAD), which occurs when the artery lumen in the lower extremities gradually becomes blocked by atherosclerotic plaque. The most frequent symptom of lower extremity PAD, called "vascular claudication," which is pain experienced when walking. Partial or total blockage of the peripheral arteries in the upper and lower limbs is called PAD. The danger of death from concurrent coronary artery and cerebrovascular atherosclerosis outweighs the risk of amputation.

Objective:

However, niosomes have issues with fusion, aggregation, leakage, vesicle sedimentation, and difficulty in sterilizing. A more recent strategy known as pro-vesicular carriers was used to solve these issues. The formulations in Proniosomes are dry and anhydrous, protected with a non-ionic surfactant that serves as a carrier when combined with water.

Materials and Methods:

Formulation prepared by organic solvent, surfactant, cholesterol, other components and hydration medium. Coacervation Phase separation Technique used for proniosome Nanoparticle. Box Bhenken Design is used for optimization batches.

Results:

In this context, we shall discuss the development of Proniosome for the treatment of peripheral arterial diseases. From here, we know that proniosome nanoparticles is pro vesicular system good characteristics and effectiveness for treating peripheral arterial diseases.

Conclusion:

Proniosomes may be created using various techniques, which may impact how they develop along with the drug's characteristics. They increase the drug's stability while being delivered while being entrapped. They don't need particular conditions for handling, protection, storage, or industrial manufacturing.
Investigating Outlier Detection Techniques Based on Kernel Rough
Clustering
Authors: Meng Wang , Wenhang Cao , Hongyan Dui
Published: September 2023

Background:

Data quality is crucial to the success of big data analytics. However, the
presence of outliers affects data quality and data analysis. Employing effective outlier detection
techniques to eliminate dirty data can improve data quality and garner more accurate analytical
insights. Data uncertainty presents a significant challenge for outlier detection methods and warrants further refinement in the era of big data.

Objective:

The unsupervised outlier detection based on the integration of clustering and outlier
scoring scheme is the current research hotspot. However, hard clustering fails when dealing with
abnormal patterns with uncertain and unexpected behavior. Rough boundaries help identify more
accurate cluster structures. Therefore, this article uses uncertainty soft clustering based on rough set
theory to extend the clustering technology and designs appropriate scoring schemes to capture abnormal instances. This solves the problem of outlier detection in uncertain and nonlinear complex
data.

Methods:

This paper proposes the flow of an outlier detection algorithm based on Kernel Rough
Clustering and then compares the detection accuracy with five existing popular methods using synthetic and real-world datasets. The results show that the proposed method has higher detection accuracy.

Results:

The detection precision and recall of the proposed method were improved. For the detection accuracy, it is superior to popular methods, indicating that the proposed method has a good
detection effect in identifying outlier.

Conclusion:

Compared with popular methods, the proposed method has a slight advantage in detection accuracy and is one of the effective algorithms that can be selected for outlier detection.
In Vivo Evaluation of Chitosan-Titanium Dioxide Nanopowder as Wound
Dressing Material
Authors: Al-Nemrawi Nusaiba , Darweesh Ruba S. , Alrousan Dana
Published: September 2023

Background:

Films used for wound healing have many advantages, but should be flexible,
robust, adherable and prevent maceration. Both Chitosan (CS) and Titanium dioxide nanopowder
(TiO2 NP) have good properties to accelerate wound healing and can be used in preparing films.

Objective:

CS and TiO2 NP are combined to formulate films for wound healing. The physical, thermal,
chemical, and mechanical characteristics of these films are to be assessed. The antibacterial activity
of the films and their performance on wounded rats will be explored.

Methods:

Films made of CS and TiO2 NP were characterized by FTIR, TGA, DSC, XRD, and SEM.
The films' mechanical characteristics and antimicrobial activity were tested. Films with acceptable
mechanical properties were evaluated on rats.

Results:

Generally, CS-TiO2 films had higher weight and thickness but lowered flexibility compared
to films prepared using CS only. The chosen film showed excellent folding endurance with weight and
thickness of around 21.98 mg and 0.16 mm. The surface pH for CS-TiO2 films was acidic, and for the
selected film, it was 5.18. CS-TiO2 film was active against all studied bacteria and significantly higher
than CS films. The antimicrobial activity of Gram-negative bacteria (P. aeruginosa and E. coli) was
higher than that of Gram-positive bacteria (S. aureus). Finally, adding TiO2 NP to the films accelerated
the healing process of the created wounds in a murine model, compared to control and CS-treated
groups.

Conclusion:

Films of TiO2 NP and CS have suitable properties to be used in wound healing and can
be further used in the future to load drugs.
Optimalisasi Publisitas Amke Sebagai Sarana Peningkatan Jumlah Wisatawan Desa Oro-Oro Ombo Batu Jawa Timur
Authors:   Fakultas Vokasi, Universitas Brawijaya, Malang, Indonesia, Susilowati Susilowati
Published: September 2023

Pandemi Covid-19 yang terjadi di Indonesia sejak 2020 berdampak pada sektor perekonomian dan pariwisata, tak terkecuali di desa wisata AMKE, Desa Oro-Oro Ombo, Batu, Jawa Timur. Masyarakat sekitar yang sebagian besar mengandalkan sektor wisata sebagai mata pencaharian merasakan dampak yang mendalam akibat pandemi. Desa wisata AMKE belum lama beroperasi pada tahun 2019 dengan menghabiskan dana yang cukup banyak untuk membuka desa wisata tersebut. Pandemi Covid-19 yang ada di Indonesia membuat desa wisata ini juga harus tutup sehingga sumberdaya manusia yang ada harus dikurangi. Maka dari itu, melalui Program Pemberdayaan Masyarakat Desa (P2MD) diharapkan dapat membantu sektor pariwisata ini bangkit kembali dengan melakukan publisitas desa wisata AMKE dan memberikan keterampilan baru kepada sumber daya manusia yang ada agar dapat mengelola kembali desa wisata AMKE di masa depan
Aplikasi Teknologi Underwater Lobster Apartment Untuk Pembesaran Lobster Pasir (P. homarus) pada Kelompok Pembudidaya Ikan (POKDAKAN) Pesona Bahari, Banyuwangi, Jawa Timur
Authors:   Fakultas Perikanan dan Ilmu Kelautan, Universitas Brawijaya, Fadjar Mohamad , Mukhammad Amrillah Attabik ,   Fakultas Perikanan dan Ilmu Kelautan, Universitas Brawijaya, Retno  Andriani Dwi ,   Fakultas Pertanian, Universitas Brawijaya, Eko  Putra  Sri  Sentanu I  Gede ,   Fakultas Ilmu Administrasi, Universitas Brawijaya.
Published: September 2023

As a continuation of the Doctoral Service 2021 activity that was carried out by this team last year at POKDAKAN Pesona Bahari, the solution offered is to design a culture container by providing insulation between individual lobsters being cultivated, as well as providing more "rooms"/spaces with Underwater Lobster. Appartment.. Underwater lobster apartment is the latest technology in lobster rearing cultivation with modification of basic cages. Lobsters obtained by POKDAKAN Pesona Bahari are raised in an Underwater Lobster Appartment measuring 2 m long x 3 m wide X 2 meters high where 1 lobster is kept in 1 apartment block. One apartment block has dimensions (LxWxH: 30cm x 15cm x 15cm) and the overall dimensions consist of 6 blocks x 10 blocks x 2 (front andback). The enlargement is carried out within a period of 30 days with regular feeding of green scallop by members of POKDAKAN Pesona Bahari. Controlling and supervision as well as data collection are carried out jointly with the UB DM team and the students involved. Based on the observations, it can be concluded that the use of the apartment lobster underwater system in lobster cultivation has a very positive effect on growth and survival reaching 100%. Water quality with the apartment lobster underwater system is maintained and does not exceed the water quality limit value for cultivation.
Exploring Affective Bibliotherapy Features in Children’s Literature for Emotional Healing and Growth
Authors: Abdul Aziz Rafidah , Wan Mohd Saman Wan Satirah , Shaifuddin Norshila , Syed Mustafa Sharifah Muzlia , Wan Mokhtar Wan Norhaliza
Published: September 2023

Recent developments in psychology have rekindled interest in the therapeutic potential of literature. Amid the COVID-19 pandemic, wherein many children lack access to conventional psychological assistance, bibliotherapy emerges as a viable aid for addressing personal issues. However, not all children's books are suitable for this purpose, necessitating meticulous scrutiny to ascertain suitable therapeutic reading materials. Through qualitative examination, this study scrutinized the affective bibliotherapy approach within fiction and illustrated books, unveiling three essential bibliotherapy attributes in children's literature. Comprehensive examples are offered for each feature, aiming to enrich future bibliotherapy research and application.
Uses of Social Media for Marketing among Entrepreneur Weavers to Sustain Songket Products in the Malay Cottage Industry
Authors: Hussin Norhayati , Ahmad Masitah , Shahibi Mohd Sazili , Mohd Tokiran Nurul Syfa’
Published: September 2023

Utilizing semi-structured interviews, this paper examines how songket entrepreneurs in Kuala Terengganu use social media for marketing. Results indicate varying levels of social media literacy among Malay women in rural areas. The AIDA model is proposed as a strategic framework to optimize their social media usage. The study suggests the need for targeted training to exploit digital opportunities fully and calls for further research on technology's role in sustaining traditional industries.
Towards Digital Resilience: Formulating strategies for farmers in a digitally disruptive environment
Authors: Hussin Norhayati , Mohd Tokiran Nurul Syfa’ , Shahibi Mohd Sazili , Ibrahim Zaharudin , Mohd Zazmi Muhammad Zaffri , Zainol Amer Shakir
Published: September 2023

This study conceptualizes a digital culture strategy to fortify the resilience and competitiveness of middle-skilled farmers in Selangor, Malaysia. Utilizing a mixed-method approach, it synthesizes the Technology Acceptance Model, Theory of Planned Behaviour, and Hofstede's cultural dimensions into a rural digital framework. The research underscores a positive correlation between strategic digital culture adoption and factors like digital literacy and farming productivity, moderated by cultural dimensions. It offers actionable recommendations for policy formulation and resource allocation, enriching existing literature on technology adoption in traditional sectors.
Evaluating the Effect of Artificial Liver Support on Acute-on-Chronic Liver Failure Using the Quantitative Difference Algorithm: Retrospective Study
Authors: Huang Tinghuai , Huang Jianwei , Liu Timon Cheng-Yi , Li Meng , She Rui , Liu Liyu , Qu Hongguang , Liang Fei , Cao Yuanjing , Chen Yuanzheng , Tang Lu
Published: September 2023

Background

Liver failure, including acute-on-chronic liver failure (ACLF), occurs mainly in young adults and is associated with high mortality and resource costs. The prognosis evaluation is a crucial part of the ACLF treatment process and should run through the entire diagnosis process. As a recently proposed novel algorithm, the quantitative difference (QD) algorithm holds promise for enhancing the prognosis evaluation of ACLF.

Objective

This study aims to examine whether the QD algorithm exhibits comparable or superior performance compared to the Model for End-Stage Liver Disease (MELD) in the context of prognosis evaluation.

Methods

A total of 27 patients with ACLF were categorized into 2 groups based on their treatment preferences: the conventional treatment (n=12) and the double plasma molecular absorption system (DPMAS) with conventional treatment (n=15) groups. The prognosis evaluation was performed by the MELD and QD scoring systems.

Results

A significant reduction was observed in alanine aminotransferase (P=.02), aspartate aminotransferase (P<.001), and conjugated bilirubin (P=.002), both in P values and QD value (Lτ>1.69). A significant decrease in hemoglobin (P=.01), red blood cell count (P=.01), and total bilirubin (P=.02) was observed in the DPMAS group, but this decrease was not observed in QD (Lτ≤1.69). Furthermore, there was a significant association between MELD and QD values (P<.001). Significant differences were observed between groups based on patients’ treatment outcomes. Additionally, the QD algorithm can also demonstrate improvements in patient fatigue. DPMAS can reduce alanine aminotransferase, aspartate aminotransferase, and unconjugated bilirubin.

Conclusions

As a dynamic algorithm, the QD scoring system can evaluate the therapeutic effects in patients with ACLF, similar to MELD. Nevertheless, the QD scoring system surpasses the MELD by incorporating a broader range of indicators and considering patient variability.
Generating Synthetic Electronic Health Record Data Using Generative Adversarial Networks: Tutorial (Preprint)
Authors: Yan Chao , Zhang Ziqi , Nyemba Steve , Li Zhuohang
Published: September 2023

UNSTRUCTURED

Synthetic electronic health record (EHR) data generation has been increasingly recognized as an important solution to expand the accessibility and maximize the value of private health data on a large scale. Recent advances in machine learning have facilitated more accurate modeling for complex and high-dimensional data, thereby greatly enhancing the data quality of synthetic EHR data. Among various approaches, generative adversarial networks (GANs) have become the main technical path in the literature due to their ability to capture the statistical characteristics of real data. However, there is a scarcity of detailed guidance within the domain regarding the development procedures of synthetic EHR data. The objective of this tutorial is to present a transparent and reproducible process for generating structured synthetic EHR data using a publicly accessible EHR data set as an example. We cover the topics of GAN architecture, EHR data types and representation, data preprocessing, GAN training, synthetic data generation and postprocessing, and data quality evaluation. We conclude this tutorial by discussing multiple important issues and future opportunities in this domain. The source code of the entire process has been made publicly available.
Investigating Walking Trends and Long-Term mHealth Intervention Effects: Implications for Metabolic and QOL Outcomes in Cancer Patients (Preprint)
Authors: Tak Yae Won , Kim Junetae , Chung Haekwon , Lee Sae Byul , Park In Ja , Lee Sei Won , Jo Min-woo , Lee Jong Won , Baek Seunghee , Lee Yura
Published: September 2023

BACKGROUND

As the number of people diagnosed with cancer continues to rise each year, technology has come to the forefront in enhancing the efficacy of self-management for patients recovering from cancer surgery or undergoing chemotherapy. Despite the growing availability of digital technologies, there remains a shortage of randomized controlled trial (RCT) evidence substantiating the effectiveness of these digital interventions for cancer patients.

OBJECTIVE

This research aimed to evaluate the influence of a prolonged mHealth intervention (Walkon) on the physical and mental well-being of cancer patients.

METHODS

Cancer patients who had previously used the Walkon app within a prior RCT study were selected as study participants. Individuals without any recorded step count data were excluded from the analysis. The Walkon app provided step count data from the patients. Biometric measurements, including BMI, waist circumference, blood sugar levels, and body composition, along with Quality of Life (QOL) questionnaire responses (EQ-5D-5L and HINT-8), were collected during both the baseline and 6-month follow-up at an outpatient clinic. To analyze step count patterns over time, the Sample Entropy module from Python was employed for patient clustering, distinguishing between the Active Walking Group (AWG) and Inactive Walking Group (IWG).

RESULTS

This study did not show significant differences in biometric data between the baseline and the six-month follow-up for both AWG and IWG groups. However, in terms of QOL assessments, pain and the Visual Analog Scale (VAS) exhibited significant differences. Nonetheless, within the realm of biometric measurements, only waist circumference and visceral fat demonstrated a noteworthy enhancement exclusively within the AWG. Furthermore, concerning the QOL questionnaire, aspects such as energy, work, depression, memory, and happiness displayed significant improvements solely in the AWG, while other factors did not exhibit statistical significance.

CONCLUSIONS

These findings indicate that a consistent, slightly higher level of physical activity, as observed in the AWG, tends to lead to substantial health improvements. Thus, cancer patients must receive a healthy level of walking enforcement.
Efficacy of eHealth Technologies on Medication Adherence in Patients With Acute Coronary Syndrome: Systematic Review and Meta-Analysis (Preprint)
Authors: Bhagavathula Akshaya Srikanth , Aldhaleei Wafa Ali , Atey Tesfay Mehari , Assefa Solomon , Tesfaye Wubshet
Published: September 2023

BACKGROUND

Suboptimal adherence to cardiac pharmacotherapy, recommended by the guidelines after acute coronary syndrome (ACS) has been recognized and is associated with adverse outcomes. Several randomized controlled trials (RCTs) have shown that eHealth technologies are useful in reducing cardiovascular risk factors. However, little is known about the effect of eHealth interventions on medication adherence in patients following ACS.

OBJECTIVE

The aim of this study is to examine the efficacy of the eHealth interventions on medication adherence to selected 5 cardioprotective medication classes in patients with ACS.

METHODS

A systematic literature search of PubMed, Embase, Scopus, and Web of Science was conducted between May and October 2022, with an update in October 2023 to identify RCTs that evaluated the effectiveness of eHealth technologies, including texting, smartphone apps, or web-based apps, to improve medication adherence in patients after ACS. The risk of bias was evaluated using the modified Cochrane risk-of-bias tool for RCTs. A pooled meta-analysis was performed using a fixed-effect Mantel-Haenszel model and assessed the medication adherence to the medications of statins, aspirin, P2Y12 inhibitors, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and β-blockers.

RESULTS

We identified 5 RCTs, applicable to 4100 participants (2093 intervention vs 2007 control), for inclusion in the meta-analysis. In patients who recently had an ACS, compared to the control group, the use of eHealth intervention was not associated with improved adherence to statins at different time points (risk difference [RD] –0.01, 95% CI –0.03 to 0.03 at 6 months and RD –0.02, 95% CI –0.05 to 0.02 at 12 months), P2Y12 inhibitors (RD –0.01, 95% CI –0.04 to 0.02 and RD –0.01, 95% CI –0.03 to 0.02), aspirin (RD 0.00, 95% CI –0.06 to 0.07 and RD –0.00, 95% CI –0.07 to 0.06), angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (RD –0.01, 95% CI –0.04 to 0.02 and RD 0.01, 95% CI –0.04 to 0.05), and β-blockers (RD 0.00, 95% CI –0.03 to 0.03 and RD –0.01, 95% CI –0.05 to 0.03). The intervention was also not associated with improved adherence irrespective of the adherence assessment method used (self-report or objective).

CONCLUSIONS

This review identified limited evidence on the effectiveness of eHealth interventions on adherence to guideline-recommended medications after ACS. While the pooled analyses suggested a lack of effectiveness of such interventions on adherence improvement, further studies are warranted to better understand the role of different eHealth approaches in the post-ACS context.
THE EFFECTIVENESS OF BLENDED LEARNING IN ENGLISH TEACHER TRAINING
Authors: Ihnatova Olena , Zhovnych Olesia , Drobakha Larysa
Published: September 2023

This research paper presents a study that was carried out with future teachers of foreign languages from three different departments of Vinnytsia Mykhailo Kotsiubynskyi State Pedagogical University, Ukraine. The pandemic has had an impact on teaching. The education sector reacted quickly to this situation and implemented e-learning in institutional facilities. The course “Digital technologies in foreign languages teaching: theories, methods, application”, which is the subject of the study presented here, was implemented. In the conception of blended learning, the course provides future teachers with the necessary skills for the teaching practice of digital tools by learning to use these technologies in a didactically sensible way. The course concept provides a hybrid learning arrangement in which the effectiveness and flexibility of e-forms of learning are combined with the social aspects of face-to-face communication. The purpose of the study was to identify the effectiveness of the integration of digital technologies in the process of learning foreign languages, the benefits of digital teaching and changes in the level of digital literacy of students. In addition, the influence of individual digital competencies, personal life situations and previous experience with similar types of courses were analyzed in terms of the effectiveness and acceptance of the Blended learning concept. The course lasted half a year; 120 students chose it. The participants are students of foreign language (English) of the three cooperating departments (Department of Methods of teaching foreign languages, Department of English Philology, Department of Translation and multicultural communication). The potential of communication technologies and teachers’ digital competence is highlighted. The research design is based on the triangulation of quantitative and qualitative methods. The results of the survey of 120 respondents from three groups revealed, firstly, the level of their motivation to register for the course; secondly, the level of their educational success, taking into account the acquired professional and digital competencies; thirdly, the level of difficulty of their cooperation in the digital based communication.
INTERNATIONAL STUDENT CONFERENCE AS A MEANS OF DEVELOPING ACADEMIC COMMUNICATION SKILLS
Authors: Rudneva Maria , Ulanova Kapitolina
Published: September 2023

The study highlights 20-year experience of organizing international student conferences in foreign languages as a framework for holistic development of academic communication skills. Conventional ESP syllabi suggest passive learning strategies, which replicate those of general English courses. Students are offered pedagogic materials which aim at reiterating the knowledge that instructors and textbooks provide. However, there exists a substantial gap between reproducing academic knowledge and becoming an independent actor in the selected field of expertise. In this sense it seems crucial to outline a framework for active independent learning for budding professionals to achieve academic autonomy at a reasonable pace. To reach this objective, we have been organizing international student conference for the LSP students at RUDN university, which is not a standalone event, but a part of ESP curriculum. Conference preparations are designed as multiple interventions aimed at developing linguistic and extra linguistic skills alike. The course on conference preparation is designed in line with the major subjects and overall academic competence of the participants. Every year Bachelor’s students write and present a research paper, which starts as a teamwork on a synopsis of studies on a given topic and eventually results in successful defense of a Bachelor’s thesis in a foreign language of the student’s choice.
VOCABULARY ACQUISITION IN ENGLISH FOR MEDICINE - STUDENTS’ PERSPECTIVE
Authors: Zafirovska Adriana , Xhaferi Brikena
Published: September 2023

The acquisition of vocabulary is a rather complex and lengthy process, and as such, it has earned immense research priority in second or foreign language acquisition. An entire division of second language acquisition is dedicated to learning strategies and taxonomies in ESL/EFL to enable students to recognize and take advantage of a variety of options for vocabulary acquisition. Students are diverse, and their needs are diverse. In the field of medicine, many professionals are internationally trained, and to express ideas clearly in English, they need to be proficient in language. Thus, they need appropriate ESP jargon and vocabulary. To serve these diverse needs of students to the fullest, teachers need to be equipped with the latest methods of teaching vocabulary acquisition. The present study aims to present the already established learning strategies for vocabulary acquisition from specialized English books related to Medical English and explore what medical books offer in terms of vocabulary acquisition, and present students’ opinions regarding vocabulary acquisition and learning strategies. Finally, to propose and give some new insight and ideas to scholars for curriculum development of English for medicine. Based on data collection, i.e., students’ questionnaires, the results showed that the ESP textbooks for medicine should be interactive and precise and not overwhelm students with general notions and ideas. As a crucial tool of instruction and curriculum design, needs analysis should be performed to give instructors and administrators an exact idea of what students want and need to succeed in their future professions. Computer-assisted vocabulary acquisition is a very likeable element of ESP medical textbooks. Thus, it should be a dominant part of ESP materials for medicine and other ESP fields.
BUSINESS RESULT: ADVANCED - STUDENT’S BOOK, SECOND EDITION - REVIEW AND CRITICAL EVALUATION
Authors: Kiss Kulenović Boglarka
Published: September 2023

The article reviews and critically evaluates the second edition of Business Result: Advanced – Student’s Book by Kate Baade, Christopher Holloway, John Hughes, Jim Scrivener and Rebecca Turner. After a brief overview of the structure of the coursebook, the article evaluates the coursebook and identifies its strengths and weaknesses, taking into consideration characteristics such as suitability of topics to the interests of target learners, suitability of teaching approach to the needs of target learners, recycling and revision of material, coverage of all four language skills, use of authentic materials (texts and audio), use of authentic tasks and flexibility of use. The article concludes with a recommendation for course instructors on the use of this coursebook.