bluuebunny/crossref_metadata_2025 huggingface dataset:
Análisis factorial del cuestionario qCT en Jóvenes Universitarios, Guadalajara México
Authors: Gutiérrez Blanca Noemí Silva , Guzmán Ulises Osbaldo de la Cruz
Published: April 2022

La evaluación de las condiciones psicosociales presentes en el entorno laboral es importante para analizar los impactos que éstas generan en trabajadores, organizaciones y sociedad. El objetivo consistió en analizar la estructura factorial del cuestionario de condiciones de trabajo propuesto por Blanch, Sahagún y Cervantes (qCT), 2010). Participaron 610 estudiantes de nuevo ingreso del Centro Universitario de Ciencias Económico Administrativas de la Universidad de Guadalajara quienes contaban con trabajo remunerado. La información se analizó a través de la técnica estadística de análisis factorial. Los resultados y conclusiones indicaron que el coeficiente alfa de Cronbrach del cuestionario qCT en general fue de .953 con una estructura compuesta de seis factores que muestran una alta consistencia interna, lo que confirma la pertinencia del uso del instrumento con fines de evaluación e investigación.
RETOS DEL INTERNATIONAL COMPLIANCE ASSURANCE PROGRAMME (ICAP) PERMANENTE DE LA OCDE COMO MODELO DE CUMPLIMIENTO COOPERATIVO MULTILATERAL
Authors:   Universidad de Alicante, Ribes Ribes Aurora
Published: April 2022

Tras dos ediciones piloto en 2018 y 2019, el International Compliance Assurance Programme (ICAP) de la OCDE adquirió en 2021 carácter permanente como programa voluntario de análisis de riesgos fiscales de grupos empresariales con presencia internacional.Este trabajo aborda el estudio de las dos versiones en pruebas, así como de la configuración y mejoras incorporadas en el ICAP de 2021, a partir de la experiencia acumulada. Se incide especialmente en los aspectos perfectibles del programa y en los resultados obtenidos hasta la fecha, con el propósito de dilucidar si el ICAP constituye verdaderamente un programa de garantía de cumplimiento cooperativo multilateral susceptible de reportar beneficios (seguridad jurídica) tanto al contribuyente como a las Administraciones Tributarias partícipes y, por tanto, un paso decidido hacia el multilateralismo en el marco del compliance tributario y la evaluación de riesgos fiscales.
LIGHTNING INJURY: A CASE REPORT ON CARDIAC EFFECTS OF LIGHTNING STRIKES
Authors: Muhammad Atif Sher , Sohail Hina , Qamar Nadeem
Published: April 2022

Lightning strikes are rare and uncommon cause of admissions into the hospitals of Pakistan. It affects every organ of the body but cardiac effects of lightning can be benign to life threatening. This case report account a case of healthy young female, who was struck by lightning in Mithi Tharparkar, developed electrocardiographic changes and prolongation of QT interval along with moderate left ventricular systolic dysfunction with segmental wall motion abnormalities on echocardiography with positive cardiac biomarkers. Angiography was done to rule out any coronary injury but it revealed normal coronaries. We kept her on follow-up which was uneventful and these changes reverted back to normal over a course of three months.
IS 3D TRANSTHORACIC PLANIMETRY STILL SUPERIOR OVER 2D ECHO IN RHEUMATIC MITRAL STENOSIS WHEN BOTH AREA AND HEMODYNAMIC PARAMETERS OF SEVERITY ARE IN QUESTION?
Authors: Ali Muhammad , Asad Muhammad , Abbas Khurram , Umair Anum , Subhani Sadia Saeed , Khadim Rehana
Published: April 2022

Objectives: The objective of the study was to compare transthoracic 3D planimetry to 2D planimetry in calculating mitral valve area along with correlation of various echocardiographic parameters of severity of mitral stenosis among these modalities.
Methodology: Patients with (RMS) were enrolled. Keeping 2D PHT as reference mitral valve area (MVA) was calculated and it was compared to the results derived by transthoracic 2D and 3D planimetry. Agreement between the 2D and 3D methods was assessed by measuring the intraclass correlation coefficient (ICC).
Results: 51 patients were included. 36 (70.6%) were females; mean age was 33 ± 6 years. Mean gradient was 14.5 ± 3.9 mmhg while mean Pulmonary artery systolic pressure (PASP) was 31.6 ± 6 mmhg. MVA’s derived by PHT, 3D planimetry, and 2D were 1.04 ± 0.24, 1.07 ± 0.24, 1.21 ± 0.27 cm2 respectively. 3D obtained areas were significantly lower compared to 2D (p< 0.001) and insignificantly greater from PHT (p = 0.18). 3D demonstrated best agreement with MVA PHT (95% limits of agreement: 0.67 to 0.92; ICC 0.84). MVA 3D planimetry and MVA 2D correlated well with PASP and mean pressure gradient but showed weak correlation with left atrium size.
Conclusion: 3D planimetry derived mitral area compared to 2D echocardiography are more in line with PHT calculated area and correlates well to hemodynamic parameters of severity.
Pengaruh Ketrampilan dan Lingkungan Kerja Non Fisik Terhadap Kinerja Karyawan
Authors: Sulistyowati Rismaya , Auliya Zakky Fahma
Published: April 2022

This research aims to determine the effect of skills and non-physical work environments on the employee performance of UD. Surya Abadi Furniture. This type of research is quantitative research. The data collection method used is to disseminate questionnaires and interviews analyzed with IBM SPSS Software version 25.0. The population used in this study were employees working at UD. Surya Abadi Furnitue with a total of 80. The sample in this study amounted to 73 respondents. The sampling technique used is probability sampling, with a simple random sampling method.The results showed that skills have a significant effect on employee performance, non-physical work environments have a significant effect on employee performance, and non-physical work skills and environments simultaneously effect employee performance
A Novel Health Model Using NuSVC to Predict Severity of Asthma on The basis Of Cough Audio Signal
Authors: Mohan Jyothi , Vutukuru Murali Mohan  , Madhusudhanan Sampath
Published: April 2022

Cough is the the major symptoms of Asthma patients. The purpose of this research is reliable assessment of cough events using sound processing tools to classify and predict severity of Asthma in patients.The system is trained to be self-learning and thus intelligent. In this research paper, patameters of the cough audio signal are analyzed. Finally, Nu Support Vector Classifier (NuSVC), is chosen as the predictor, due to its superb classification and feature selection ability. Finally, end result of severity of Asthma patients is predicted. However for the research purpose, the cough sound recording of Asthma training data set is created. The trained model is used for further classification and prediction of health severity. The model classified and predicted with 94% accuracy compared to previous work.
Does Modigliani and Miller Relevance and Irrelevance Theory of Capital Structure Apply Among Non – Finance Quoted Companies in Ghana?
Authors:   University of Benin, Edo State, Nigeria, Anwuli, NWOKOYE, Gladys
Published: April 2022

This study tests the applicability of Miller and Modigliani relevance and irrelevance theories for a set of 15 companies in Ghana using that for the period 2010 to 2019. The test procedure invoved examining how debt to equity ratios affect the value of the firms in the market, including how tax shield provided from debt accumulation improves the firms’ value. The result from the empirical analysis shows that neither the irrelevance nor the relevance theory is prevalent among the quoted firms in the non-finance sector in Ghana over the reference period. Empirical evidence also indicate that debt structure does not infleunce firm value (that is, the use of long term or short term debt pattern does not matter for firm value) among the sampled firms. The result also shows that debt to equity ratio does not influence firm performance. Moreover, tax shield from use of debt is shown to have no significant influence on the changes in firm value STATA computer econometric software package. The estimation was carried out using the Stata 13.0 statistical software.
Critical Analyses of Liberia’s Bicentennial Celebration: A Way Forward to a New Historical Narrative and Development Tangibility
Authors:   Lecturer at AME University Graduate School, Cuttington University Graduate School of Global Affairs Policy and Foreign Service Institute, Ministry of Foreign Affairs, Liberia Founder and Managing Director of African Institute for Development Research, Sumaworo Dr. Mory
Published: April 2022

The land known today as Liberia existed with rich civilizations; well institutionalized tribal governance and political structures that functioned well to meet the political, economic and spiritual demands before the Western Civilization that came along with repatriation of the Americo-Liberians or the settlers in the early 1800s. Before 1822, there were socio-political establishments and institutions, the likes of Condo Confederation of the Mandingo leader, King Sa Bosso Kamara, King Jack Ben of Jumbo Town of Grand Bassa, King Brister, a Dei ruler, King Zolu Duma or Peter Careful as known by European of Gon (the Capital City of his Kingdom on North Lofa River) and others are some of the historical indigenous figures and their leadership ability and kingdoms are illustrations of existing socio-political civilizations before the docking and berthing of the Elizabeth; a Ship that brought the first batch of America-Liberians ( Freed Slaves) in 1822 at Dozoa Island ( Providence Island), from North America. Further, this year marks the exact two centuries since the arrival of settlers. The event has been widely celebrated in the midst of incomparable development and economic successes as per the years of the nation’s existence; the so-celebrated class (the settlers) governed the State from 1847-1980 under the Republican and the True Whig Parties respectively with the same injustice and socioeconomic apartheid-like of leadership that they escaped from, from the USA, and from 1980-2022 under the so-called majority native people led-admirations, the country stays economically and developmentally bleeding . Thus, there is a dire need to a radically change the State’s behaviour by fighting corruption and prioritizing sustainable development and shared economic prosperity that has been compromised over the last 200 years to meet the aspiration of the people (Liberians). Hence, this paper aims at exploring some of the historical ambiguities and factors that led and contributed to incomparability of Liberia’s 200 years with her development and economic achievement. Nations’ success are measured by their tangible achievement not only how long they have been in nationhood.
An Educational and Laboratory Device That Demonstrates the Properties of Light as a Stream of Quasiparticles-Photons
Authors:   Senior teacher, Department of “Digital electronics and microelectronics”, Tashkent State Technical University, Tashkent, Uzbekistan, Sattorov Abdujalol Abdukhamidovich
Published: April 2022

In this work a teaching-laboratory device was created for students of secondary schools, academic lyceums and colleges, as well as for students of higher educational institutions to study the phenomenon of internal and external photoeffects and to perform laboratory works in the field of physics optics. The device presents the results obtained on the basis of experiments proving that light consists of a flux of quasi-particle photons. The created device fully demonstrates the most important phenomena of physics, as well as such qualities as safety, ease of use, the possibility of individual work of students, does not require an external energy source and cheapness allow to use this device widely.
The Effect of Effective Communication & Work Motivation on Nurse Performance in ICU Room at Panembahan Senopati Hospital, Bantul
Authors:   Master in Hospital Administration, University of Muhammadiyah Yogyakarta, Yogyakarta, Dewi Hapsari Kartika
Published: April 2022

Background: Improving the quality of health services, especially in hospitals, can be achieved by implementing health services by the standards and ethics of professional services. The performance of nurses is one of the essential components that can describe the fulfillment of these service standards and ethics. Effective communication and work motivation are two factors that will affect the performance of nurses. Methods: This study is a quantitative study with a cross-sectional design involving 12 nurses in the ICU ward of Panembahan Senopati Hospital Bantul. Research data was obtained using a questionnaire. Results: There is no relationship between effective communication and nurse performance (p = 0.166). There was no relationship between work motivation and the performance of nurses in the ICU ward at Panembahan Senopati Hospital Bantul (p = 0.488). Conclusion: Effective communication and work motivation of nurses did not affect the performance of nurses in the ICU Room at Panembahan Senopati Hospital, Bantul.
Content of Fifty Trace Elements in Thyroid Benign Nodules and Thyroid Tissue adjacent to Nodules investigated using Neutron Activation Analysis and Inductively Coupled Plasma Mass Spectrometry
Authors:   Radionuclide Diagnostics Department, Medical Radiological Research Centre, Russia, Zaichick Vladimir
Published: April 2022

Thyroid benign nodules (TBNs) are the most common diseases of this endocrine gland and are common worldwide. The etiology and pathogenesis of TBNs must be considered as multifactorial. The present study was performed to clarify the role of some trace elements (TEs) in the etiology of these thyroid disorders. Thyroid tissue levels of fifty TEs were prospectively evaluated in nodular tissue and tissue adjacent to nodules of 79 patients with TBNs. Measurements were performed using a combination of non-destructive instrumental neutron activation analysis and destructive method such as inductively coupled plasma mass spectrometry. Results of the study were additionally compared with previously obtained data for the same TEs in “normal” thyroid tissue. This study provides evidence on many TEs level alteration in nodular and adjacent to nodule tissue and shows the necessity to continue TEs research of TBNs.
Geotechnical Practice of Slope Reinforcement
Authors:   OOO NPF «FORST» (109a, ul. Kalinina, 428000, Cheboksary, Russian Federation), Sokolov N.S. ,   Federal State-Funded Educational Institution of Higher Education «I.N. Ulianov Chuvash State University» (15, Moskovskiy pr., 428015, Cheboksary, Russian Federation)
Published: April 2022

Geotechnical construction is one of the most important branches of the construction of zero parts of objects for various purposes. The existing rich potential of geotechnical technologies allows us to successfully perform the tasks of building foundations for buildings in any engineering and geological conditions and on any territory, including slopes, ravines, embankments. Very often there are cases of erection of objects on rugged territories with alternating structurally unstable soils, moreover, additionally loaded with artificial leaning slopes. In geotechnical practice, there are still cases of construction on such slopes without proper engineering and technical support, i.e. without the presence of actually carried out engineering surveys, as well as developed antilandslide measures. Ultimately, in most cases, the neglect of generally accepted standards leads to undesirable consequences, expressed in deformations of the constructed buildings. This article considers one such case.
Childhood Lennox-Gastaut Syndrome, Low Set Ears, Unilateral Cryptorchidism: A New Variant
Authors:   Advisor in Pediatrics and Pediatric Psychiatry, Children Teaching Hospital of Baghdad Medical City and the National Training and Development Center, Iraq, Jalal Al-Mosawi Aamir
Published: April 2022

Background: Childhood Lennox-Gastaut syndrome is a heterogeneous epileptic encephalopathy with onset between the age of one and seven years. It is associated with more than one seizure type that are drug-resistant, a slow spike-wave activity in the EEG recording and mental retardation .The syndrome was first described by William Gordon Lennox in 1950, and later by Henri Gastaut in 1966. The condition was first called “Lennox-Gastaut syndrome” by Ernst Niedermeyer in 1968. The association of Lennox-Gastaut syndrome with low set ears and cryptorchidism has not been reported before. Patients and Methods: A two and three months boy was referred late during February, 2022 because of seizures that started during the last week of December, 2021 and were not controlled with multiple anti-epileptic drugs. The diagnosis was made and an evidence-based therapeutic approach is described. Results: When the boy was first seen he was still experiencing frequent generalized tonic clonic seizures that may last for about ten minutes and myoclonic seizures, despite he was receiving four anti-seizure drugs in good doses including valproic acid, clobazam, levetiracetam, topiramate. The drugs made the boy sleepy most of the day. Brain MRI was performed during August, 2021 for the evaluation of developmental retardation showed normal findings. The presence of more than seizure type, the EEG recording, and the developmental and retardation together with resistance of seizures to polytherapy allowed confident diagnosis of Lennox-Gastaut syndrome. Anti-epileptics were replaced with other drugs and evidence-based agents were used for neuroprotection and improving development and mental retardation. Treatment was associated with a significant improvement. Conclusion: A new variant of childhood Lennox-Gastaut syndrome is reported and the experience with its early treatment is described.
Primary Gastric Lymphoma: A Silent Assassin
Authors:   Associate Professor, Medicine, Ad-din Women’s Medical College Hospital, Dhaka Bangladesh, Gomes Richmond R
Published: April 2022

The gastrointestinal (GI) tract is the predominant site of extra nodal lymphoma involvement. Gastric lymphoma is the most common extra nodal site of lymphoma. Most of these lesions are either extra nodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT) type or diffuse large B cell lymphoma (DLBCL). Primary gastric lymphoma accounts for less than 5% of gastric cancers. They are usually non-Hodgkin’s lymphomas (NHL), but have been considered as a separate entity from NHLs of peripheral nodes. The diagnosis of primary lymphoma of stomach requires histological confirmation without any evidence of peripheral lymphadenopathy or organomegaly. Secondary gastric lymphoma indicates the involvement of the stomach by a diffuse lymphoma developed elsewhere. We report a 60 years old male presented with intermittent vomiting and reflux symptoms. Upper GI endoscopy showed large hard mass with superficial ulceration in the fundus of stomach. Histopathology showed lymphoproliferative disorder. Immunohistochemistry confirmed positive CD 20 and BCL 2 suggestive of extranodal marginal zone B cell lymphoma. Subsequently, he was referred to surgery and oncology department for further management.
Glioblastomas - Study Using Molecular Markers
Authors:   Candidate of Biological Science, Assistant Professor of Pathophysiology department named D.A. Maslakov, Grodno State Medical University, Repablic of Belarus, EI Bon , Vihanga B Th ,   A 3rd-Year Student-Group of Faculty of Foreign Students Grodnok Statek Medicalm University, Republic of Belarus
Published: April 2022

Glioblastoma is a lethal tumor that can develop in the central nervous system. The most serious type of brain cancer is known as glioblastoma multiforme (GBM). This work aims to emphasize the usage of different glioblastoma markers during the diagnosis process and the treatment of the GBM. And also this may focus on the changes that are often associated with GBM pathogenesis and understanding the significance of glioblastoma markers, as well as their involvement in numerous critical cellular signaling pathways, can help direct potential research toward novel GBM treatments.
Why Global Glaciations Happened
Authors:   Petrozavodsk State University, Petrozavodsk, Russia, Orlov Sergey
Published: April 2022

Proof of the reason for the repeated changes in the eccentricity of the Earth’s orbit, which caused worldwide glaciations on Earth, is offered.
Evaluation of Lithological Influence on Seismic Wave Velocity in Part of Niger Delta, Nigeria
Authors:   Department of Physics, Faculty of Science, Rivers State University, Nkpolu-Oroworukwo Port Harcourt, Nigeria, Ben Chukwu C. , Paddy Ngeri A. ,   Department of Geology, Faculty of Science, Rivers State University, Nkpolu-Oroworukwo Port Harcourt, Nigeria
Published: April 2022

This study is aimed at evaluating the influence of lithology on seismic wave velocity in part of Niger Delta. A suite of geophysical well log comprising of gamma ray, sonic and density logs in Log Ascii Standard (LAS) format from two exploratory wells (OKO 5 and OKO 7) within the study area was used for this study. Gamma ray log was used to identity and delineate the lithology into shale and sand units, seismic wave velocity was categorized into compressional wave velocity Vp and shear wave velocity Vs. The former was computed from interval transit time while the later from compressional wave velocity. The results of this study show that seismic wave velocity is very much affected by difference in the lithology of formation. Compressional wave velocity (Vp) is higher than shear wave velocity (Vs) in shale and sand lithologies in the two wells. The values of the compressional wave velocity, shear wave velocity, percentage volume of shale and percentage volume of sand ranges from 3485 to 6620m/s, 2159 to 3932m/s, 2682 to 5323m/s, 1736 to 3161m/s, 11 to 60%, 13 to 59%, 40 to 89% and 29 to 87% for the two wells respectively. The knowledge of this study can be applied in civil engineering and engineering geophysics activities like foundation for high rise buildings, dams, bridges and road construction.
Assessment of Soil Nutrients Enhancement by organic NPK® (compost) and Urea under Sesame (Sesamum indicum L.) Cultivation in Makurdi, Nigeria
Authors:   Department of Soil Science, Federal University of Agriculture, P.M.B.2373, Makurdi, Nigeria, Ter T.S. , Ali E.T. ,   Department of Soil Science, Federal University of Agriculture, P.M.B.2373, Makurdi, Nigeria
Published: April 2022

In Nigeria, soil nutrient losses occasioned by inappropriate land uses are negatively impacting on food security for the growing population. The escalating cost of mineral fertilizers has limited the use of the commodity by smallholder farmers who produces most of the food consumed in the country. In this context, the use of organic materials as a soil amendment is critical to optimized crop yield per unit area of land. This experiment examined soil nutrient enhancement using organic NPK® and urea under sesame cultivation in Makurdi, Nigeria. The result from the study showed that, application of organic NPK® improves soil organic matter content and raises soil pH, total Nitrogen, available Phosphorus, and exchangeable cations. Similarly, seed weight of sesame positively correlated with manure and urea. It was deduced that yield obtained by addition of organic NPK® at 400kg/ha was statistically the same with yield obtained from urea at 150 kg/ha. This result implies that organic NPK® is a suitable substitute for fertilizer urea for sustainable cultivation of sesame.
Development of Complimentary Food from Soy Bean and Soy by –Products
Authors:   Department of Food Science and Technology, Obafemi Awolowo University, Ile-Ife, Nigeria, Samson Ishola Ibironke
Published: April 2022

Shortage of Animal protein has led Researcher to quest for plant protein for children transition to Adult survival. Although total breastfeeding is more convenient and advocated for childhood growth from ages 1 to 6 months. The study aimed to examine the Complimentary foods that was developed from soy bean and soy by –product. The Plant based complimentary food was formulated as follows soydehulled 10 %(SD) , Whole soy10% (SW), soymilk10%(SM) and control dietary(CD) and basal (BA100) . The study considered Growth Response, the weight of the endocrine, the nitrogen retention of the experimental animal the nitrogen retention of the experimental animal The Outcome of the experimental Animals fed with (SD) , (SW), (BA), (SM) and control dietary(CD) basal (BA100%), shows weight gain by 52.47g ,23.99g, 25.57g,38.95g and basal diet loss weight by -0.38g respectively. The performance revealed that plant based complementary foods has potential to promote growth was compared favourable with control dietary but the basal diet (negative control) could not promote growth because it is deficient in amino acid such as tryptophan and lysine. In conclusions plant based complementary food is cheap, available and could replace animal based food that has been linked with some medical ailments such as, c, osteoporosis, high blood pressure a cholesterol and childhood obesity. Soy Plant protein based contain low calories, carbohydrate, and free fatty acid similar to fish protein which is important for people who are allergic to cow protein milk and lactose.
Comparison of frequency of seroma formation in laparoscopic para umbilical hernia repair with and without primary closure of defect
Authors: Khan Shamin , Maryam Siddiqa  , Habib Ur Rehman
Published: April 2022

Objective: To compare the frequency of seroma formation in laparoscopic para-umbilical hernia repair with and without primary closure of defect.
Method: The randomised parallel group study was conducted at the Department of Surgery, Bahawal Victoria Hospital, Bahawalpur, Pakistan, from October 1, 2019, to May 31, 2020, and comprised patients of both genders age 25-65 years diagnosed as a case of para-umbilical hernia. The patients were randomised into group A which subsequently had laparoscopic primary repair of defect with non-absorbable suture prior to mesh placement, and group B which had laparoscopic repair without primary closure of the defect. Case sheets of patients were prepared for age, gender, duration of disease, operating time, body mass index and the presence or absence of seroma formation. Data was analysed using SPSS 20.
Results: Of the 100 patients, 35(35%) were males and 65(65%) were females with male-to-female ratio of 1:1.9, and an overall mean age of 43.92±10.77 years.  Both groups had 50(50%) patients each. . Post-operative seroma formation  was noted in 1(2%) group A patient and 12(24%) group B patients (p=0.001).
Conclusion: Primary closure of the fascial defect in laparoscopic para-umbilical hernia repair resulted in decreased frequency of post-operative seroma formation.
Key Words: Paraumbilical hernia, Seroma, Laparoscopic paraumbilical hernia repair.
Aducanumab- a Drug of hope for the elderly
Authors: Muhammad Kashan Zaheer  , Wajiha Siddiqi  , Ghana Raza
Published: April 2022

Madam, Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by impaired cognitive functions in a person (1). It is the most common cause of dementia and a major cause of morbidity and mortality in the elderly. Currently, 50 million people in the world live with dementia, AD accounting for more than half (50-75%) of all cases (2). Despite such an extensive burden of the disease, existing management options such as cholinesterase inhibitors and NMDA antagonists have failed to improve disease progress and are mainly focused on treating the symptoms.
Last month, on the 7th of June 2021 the U.S. Food and Drug Administration (FDA) approved Biogen® 's Aducanumab (ADU), an anti- beta-amyloid (A?) monoclonal antibody for the treatment of AD (3). Although controversial, the FDA’S approval of the drug marks a historic event in the fight against this debilitating disease. ADU represents the first of its kind treatment against AD. It is the only new Alzheimer’s drug to be approved in almost two decades and it’s also the first drug to target A?, a hallmark of AD pathophysiology. In a study, 3382 patients with AD were enrolled on three clinical trials to check for its efficacy. Patients who received the drug showed a time-dependent reduction of beta-amyloid plaque, while on the contrary, those on placebo did not. (4) However, due to inconsistent results in the phase III trials (5), FDA requires Biogen to conduct a post-approval trial to verify clinical benefit. Failing to do so, may result in the FDA withdrawing the approval. Despite limited evidence regarding its efficacy, annual ADU therapy is priced at U$D56000, raising healthcare equity, accessibility, and affordability concerns.
Presently 60% of the world’s population living with dementia belongs to low-middle income countries, by 2050 this number shall expectedly rise to 71%. Along with its South Asian and Western Pacific neighbors, Pakistan comprises the world’s fastest-growing elderly population (6), which ultimately means more people with AD. This means we require efficient therapy options to fight an ever-growing disease burden in the upcoming years. Therefore, it is pivotal to acknowledge that ADU the first therapy to halt AD progression, is a milestone achieved in its treatment. It should be considered as a step forward towards the path to finding a cure.
FORMAL JUSTICE AND ALTERNATIVE DISPUTE RESOLUTION ON LAND BASED CONFLICTS IN KENYA
Authors: Mutuku Benson , Alaii Jane , Krumeich Anja , Hubertus van den Borne , Westerndorp Ingrid
Published: April 2022

This article highlights the use of formal justice and Alternative Dispute Resolution (ADRs) mechanisms in resolving land based conflicts in Kenya. The research employed a desk review method through the review of books, articles, documents, reports and internet information. Findings reveal that symbiotic relationship and equitable value of both the formal justice system and ADR are recognised by the Constitution of Kenya 2010. The court system in Kenya is established under the Constitution and various other Acts of Parliament land dispute suits matters are filed at the civil court registry of a lower or magistrates court or at the Environment and Land Court through its registry. On the other hand, the use of ADR mechanisms offers different advantages compared to the formal court system, including effective and efficient of resources such as time and money. It reduces the time it takes to resolve disputes, particularly in tribunals and traditional and alternative justice systems, and diminish the backlog of cases experienced by the courts. The article provides a better understanding of the two systems in terms of their merits and demerits and recommends that the Government of Kenya does more to build capacity by providing formal training at the local level in the different ADR methods to help disputants resolve conflict before it is channelled through the formal justice system. It also recommends that it create a public fund and a corresponding application process that would allow those who cannot afford to privately hire advocates to prosecute or defend their matters in Court through the said fund.
EFECTIVIDAD DE LAS SESIONES DEMOSTRATIVAS PARA MEJORAR EL CONOCIMIENTO EN LA PREVENCIÓN DE LA ANEMIA EN GESTANTES, MADRES LACTANTES DE NIÑOS MENORES DE 3 AÑOS. CENTRO DE SALUD APARICIO POMARES. HUÁNUCO – PERÚ
Authors: Tamayo García Mónica R. , Miraval Tarazona Zoila E. , Miraval Tarazona Lincoln A. , Mondragón Miraval Susan L.
Published: April 2022

Introducción: El problema de la anemia está muy relacionado a los índices de pobreza, falta de cuidado de la salud y educación de la población, pero principalmente a la falta de conocimientos sobre alimentación y nutrición infantil por parte de las madres. Objetivo: Determinar la efectividad de las sesiones demostrativas para mejorar el conocimiento en la prevención de la anemia en gestantes, madres lactantes de niños menores de 3 años. Materiales y Métodos: El estudio fue de tipo experimental, descriptivo y de nivel observacional, explicativo y analítico. La población de estudio estuvo conformada por 200 gestantes, obteniendo una muestra de 30 gestantes y 20 madres lactantes de niños menores de 3 años, haciendo un total de 50 pacientes, se utilizó el cuestionario para la recolección de datos, aplicado en dos momentos; antes y después de las sesiones demostrativas, con la finalidad de comparar los resultados. Resultados: El nivel de conocimiento teórico de las madres, luego de la aplicación de las sesiones demostrativas se incrementó su nivel a un conocimiento alto. Respecto a los conocimientos prácticos luego de la aplicación de las sesiones, se logró un conocimiento alto. Conclusiones: La técnica de sesiones demostrativas en el incremento de conocimientos es efectiva.
 
SUMMARYIntroduction: The problem of anemia is closely related to the rates of poverty, lack of care of the health and education of the population, but mainly to the lack of knowledge about food and infant nutrition by mothers. Objective: To determine the effectiveness of the demonstration sessions to improve knowledge in the prevention of anemia in pregnant women, nursing mothers of minor children 3 years old Materials and methods: The study was of type, experimental, descriptive and observational level, explanatory and analytical. The study population consisted of 200 pregnant women, obtaining a sample of 30 pregnant women and 20 lactating mothers of children under 3 years of age, making a total of 50 patients, the questionnaire was used for data collection, applied in two moments; before and after demonstration sessions, in order to compare the results. Results: The level of theoretical knowledge of the mothers, after the application of the demonstrative sessions their level to high knowledge. Regarding the practical knowledge after the application of the sessions, high knowledge was achieved. Conclusions: The technique of demonstrative sessions in the increase of knowledge is effective.
Роль воспитания духовно развитого поколения в развитии государства
Authors: Маматкулова Гульзода
Published: April 2022

В статье раскрывается роль  духовности в воспитание целостного развития детей в контексте дошкольного образования. Духовно-нравственное воспитание в современном обществе будет успешным, если будут созданы условия, способствующие формированию культурного поведения. Можно сказать, что формирование духовно- нравственного воспитания во многом зависит от методов воспитания и от условий, в которых он живет.
Aplikasi Berbasis Android untuk Monitoring dan Pengontrolan Pertanian Pintar
Authors: Prawitha Winda Mega , Sulistyanto Muhammad Priyono Tri , Wasum Wasum
Published: April 2022

Di perkembangan teknologi pengendalian sistem dan monitoring alat bisa dilakukan melalui aplikasi berbasis android, sistem kendali ini juga sudah bisa terkoneksi ke Internet of Things. IoT sendiri juga sudah mulai merambah kesektor pertanian, akan tetapi di Indonesia masih kurang adanya pengembangan di bidang ini, untuk itu peneliti membuat suatu aplikasi berbasis android yang terkoneksi dengan alat pertanian pintar melalui web server. Dalam aplikasi ini pengguna bisa melalukan monitoring tumbuhannya (Sayuran Sawi) mulai dari umur tanaman, cek kadar air hingga kelembaban suhu. Pengguna juga bisa melakukan pengontrolan alat pertanian pintar untuk melakukan aksi seperti menamam, menyiram, hingga memanen tanaman secara otomatis. Dalam aplikasi ini titik koordinat penanaman bibit tumbuhan juga sudah diatur dengan jarak 15 cm antar tanaman agar tidak mengganggu proses pertumbuhan tanaman
The Impact of Changes in Basel Capital Requirements on the Resilience of African Commercial Banks
Authors: Oyetade Damilola , Obalade Adefemi A. , Muzindutsi Paul-Francois
Published: April 2022

Focusing on a panel sample of 41 commercial banks over the period of 2000-2018, this study examined the effect of capital adequacy on the resilience of commercial banks in Africa under changing Basel levels (II, III, and the proposed Basel IV). The study created sample representative banks for the proposed Basel IV and used two measures, namely Z-score and CAMELS, to capture bank resilience. Using the panel logistic regression and fixed effect model, we found that capital adequacy, liquidity, earnings management efficiency, and macroeconomic conditions are key determinants of the resilience of commercial banks in Africa. Additionally, Basel compliant banks tend to be less prone to macroeconomic factors. Based on the positive and significant impact of all Basel capital ratios on Zscore, the results suggest that a high level of capital requirements increases African banks' resilience, and banks with higher capital can absorb risk exposures.
The Effect of Government Debt on Private Investment in Advanced Economies: Does Institutional Quality Matter?
Authors: Nguyen Van Bon
Published: April 2022

Unlike developing economies, advanced economies easily borrow debt to finance budget deficits. Government debt is one of the active measures of fiscal policy in these economies to run the economy and overcome its cyclicality. Most related studies note that government debt reduces private investment. Does it hold for advanced economies? Does institutional quality significantly affect the government debt – private investment relationship in these economies? For the answer, the study applies the PMG estimator (PMG) and the two-step difference GMM Arellano & Bond estimator (D-GMM) to investigate the impacts of government debt, institutional quality, and their interaction on private investment in 36 advanced economies from 2002 through 2019. The estimated results report that government debt crowds out private investment, while institutional quality enhances it. However, their interaction crowds out it. It seems counter-intuitive. Besides, economic growth and trade openness increase private investment while inflation decreases it. These results indicate the crucial implications for central governments in advanced countries in using and managing government debt.
Fibromyalgia in patients with migraine: A literature review in the last 20 years
Authors: Fortes Yasmine Maria Leódido , Souza Wallyson Pablo de Oliveira , Silva-Néto Raimundo Pereira
Published: April 2022

IntroductionPossibly fibromyalgia and migraine share similar pathophysiological mechanisms, generatingan imbalance of neurotransmitters involved in pain modulation, with increased neuronal excitability. The association between these two conditions is frequent, increasing the disability of both.ObjectivesWe aimed to review articles published in the last 20 years about the presence of fibromyalgiain patients with migraine and to analyze the quality of life of these patients.MethodsBased on a literature search in the major medical databases and using the descriptors “migraine” and “fibromyalgia” we include articles published between 2001 and 2021. We found 387 articles, but only five met the inclusion criteria.ResultsIn five articles analyzed, 429 patients with migraine were found, in which fibromyalgiawas present in 31.5% of them, predominantly in women (p<0.0001). In this association, there was a higher risk for depression and worse quality of life.ConclusionsThe association of fibromyalgia in patients with migraine is frequent, increasing the disabilityof these two diseases and generating great social impact. Knowledge of this association and the management of its consequences are necessary in medical practice.
It is wrong to treat pain in CSF hypotension headache (post-lumbar puncture headache) to allow the patient to walk!
Authors: Valença Marcelo Moraes , e Sousa Matheus Salerno Sousa Miguel , Valença Marcelo Andrade , Carvalho Déborah Emmily de , Silva Alberto Henrique Torres Trindade da , Andrade Juliana Ramos de
Published: April 2022

It is wrong to treat pain in CSF hypotension headache to allow the patient to walk!
International Classification of Orofacial Pain – ICOP – Brazilian Portuguese version
Authors: Conti Paulo Cesar Rodrigues , Gonçalves Daniela Aparecida de Godoi
Published: April 2022

There is no abstract since it is an Editorial.
Numerical reckoning fixed points via new faster iteration process
Authors: Ullah Kifayat , Ahmad Junaid , Khan Fida Muhammad
Published: April 2022

In this paper, we propose a new iteration process which is faster than the leading S [J. Nonlinear Convex Anal. 8, no. 1 (2007), 61-79], Thakur et al. [App. Math. Comp. 275 (2016), 147-155] and M [Filomat 32, no. 1 (2018), 187-196] iterations for numerical reckoning fixed points. Using new iteration process, some fixed point convergence results for generalized α-nonexpansive mappings in the setting of uniformly convex Banach spaces are proved. At the end of paper, we offer a numerical example to compare the rate of convergence of the proposed iteration process with the leading iteration processes.
Some generalizations for mixed multivalued mappings
Authors: Aslantaş Mustafa , Sahin Hakan , Sadullah Uğur
Published: April 2022

In this paper, we introduce a new concept of KW-type ω-contraction mixed multivalued mapping. After that, we obtain some fixed point results for both multivalued and single valued mappings Finally, we provide a noteworth example to show the effectiveness of our result.
Boyd-Wong contractions in F-metric spaces and applications
Authors: Bera Ashis , Dey Lakshmi Kanta , Som Sumit , Garai Hiranmoy , Sintunavarat Wutiphol
Published: April 2022

The main aim of this paper is to  study the Boyd-Wong type fixed point result in the  F-metric context and apply it to obtain  some existence and uniqueness criteria of solution(s) to a second order initial value problem and a Caputo fractional differential equation. We substantiate our obtained result  by finding a suitable non-trivial example.
On w-Isbell-convexity
Authors: Olela Otafudu Olivier , Sebogodi Katlego
Published: April 2022

Chistyakov introduced and developed a concept of modular metric for an arbitrary set in order to generalise the classical notion of modular on a linear space. In this article, we introduce the theory of hyperconvexity in the setting of modular pseudometric that is herein called w-Isbell-convexity. We show that on a modular set, w-Isbell-convexity is equivalent to hyperconvexity whenever the modular pseudometric is continuous from the right on the set of positive numbers.
Análisis multi-objetivo del problema de asignación del buffer con meta-modelos de simulación y una metaheurística híbrida
Authors: Hernández-Vázquez José Omar , Hernández-González Salvador , Hernández-Vázquez José Israel , Jiménez-García José Alfredo , Hernández-Ripalda Manuel Darío
Published: April 2022

Este artículo presenta una formulación multi-objetivo del problema de asignación del buffer (BAP, por sus siglas en inglés) en una línea de producción paralela en serie, que pretende maximizar la tasa promedio de producción y minimizar el costo total de la asignación de buffers. Se analizan tres casos de estudio que involucran condiciones de operación: confiables, no confiables y reprocesos. Los tiempos de proceso, tiempos entre fallas y tiempos de reparación, consideran funciones de distribución: Exponencial, Normal y Weibull. El método de evaluación empleado en este documento, implica meta-modelos de simulación construidos a partir de diseños de experimentos y simulaciones de la línea de producción; por su parte, el método de optimización implementado, es una metaheurística híbrida de Algoritmos Genéticos (AG) y Recocido Simulado (RS). Los resultados reportan la asignación de buffers en los casos de estudio, su impacto en los objetivos y la eficiencia computacional del algoritmo híbrido propuesto.
Socioeconomic status and mental health during the COVID-19 crisis: Are sense of coherence, sense of community coherence and sense of national
coherence predictors for mental health?
Authors: Pijpker Roald , van der Kamp Dani , Vader Sarah , den Broeder Lea , Wagemakers Annemarie
Published: April 2022

Background

Evidence about the impact of the COVID-19 pandemic on existing health inequalities is emerging. This study explored dif-ferences in mental health, sense of coherence (SOC), sense of community coherence (SOCC), sense of national coherence (SONC), and social support between low and high socioeconomic (SES) groups, and the predictive value of these predictors for mental health.

Material and methods

A cross-sectional study was conducted using an online survey in the Netherlands in October 2021, comprising a total of 91 respondents (n = 41, low SES; n = 50, high SES).

Results

There were no differences in mental health, SOC, SOCC, SONC, and social support between the groups. SOC was a predictor for mental health in both groups and SOCC for the low SES group.

Conclusions

We found that both SOC and SOCC predict mental health during the pandemic. In the article we reflect on possible path-ways for strengthening these resources for mental health.
Religious Autonomy and Local Religion among Indigenous Confraternities in Colonial Mexico, Sixteenth-Seventeenth Centuries
Authors: Dierksmeier Laura
Published: April 2022

Confraternities were indispensable charitable institutions in colonial
Mexico. Not only did missionaries see the potential of confraternities as
a vehicle for evangelization, but also indigenous people themselves used
Christianity as a tool for their own protection and survival. Whether it be
in their hospital work or economic transactions, indigenous people ultimately
became advocates of their own Christianity to advance their social
status and power, and to negotiate their community positions. Indigenous
customs were by no means eradicated within the new colonial society, and
evidence of hybrid practices and local religion can be seen in the activities
of confraternity members. By drawing on indigenous symbols and styles
and fusing Christian saints with ancestral deities, indigenous people formed
a Christianity of their own that was neither fully “orthodox” nor wholly
“unorthodox.” Between these two extremes, confraternity life fluctuated
dynamically. What emerges from confraternity records, often written in
Nahuatl with finances recorded in Aztec currencies, can aptly be called
“Nahua Christianity,” a combination of pre- and post-conquest religiosity.
Confraternities of People of African Descent in Seventeenth-Century Mexico City
Authors: Masferrer León Cristina Verónica , Hidalgo Javiera Jaque
Published: April 2022

This chapter discusses black confraternities in colonial Mexico City,
their form of organization, their beliefs and practices, as well as their
connection to specific instances of resistance. This analysis shows that
confraternities were communal spaces that allowed Afro-Mexicans to
develop social relations that in turn allowed them to recreate and preserve
certain elements of their identity, while also allowing them to interact
with members of other ethnic groups. This chapter also underscores that
while confraternities allowed Afro-Mexicans to integrate into colonial
society, they were also seen as a threat to the established order, precisely
due to the cohesiveness of their social relations.
Black Brotherhoods in Colonial Brazil
Authors: Borges Célia Maia , Dantas Lobato Bruna
Published: April 2022

There were innumerable black brotherhoods in colonial Brazil. With the
objective of promoting devotional practices and Catholic practices, brotherhoods
had a central role in fostering solidarity among the members. Afro-
Brazilians and enslaved Africans made up the black Rosary brotherhoods
of colonial Brazil. Endorsed by the Church and Crown, these institutions
constituted Afro-Brazilians’ sole means of social association. This chapter
studies the meaning of membership in Afro-Brazilian brotherhoods and
emphasizes the centrality of rituals in the formation of new social identities.