bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategies to Improve the Potential Functionality of Fruit-Based Fermented Beverages
Authors: Keșa Ancuța-Liliana , Pop Carmen Rodica , Mudura Elena , Salanță Liana Claudia , Pasqualone Antonella , Dărab Cosmin , Burja-Udrea Cristina , Zhao Haifeng , Coldea Teodora Emilia
Published: October 2021

It is only recently that fermentation has been facing a dynamic revival in the food industry. Fermented fruit-based beverages are among the most ancient products consumed worldwide, while in recent years special research attention has been granted to assess their functionality. This review highlights the functional potential of alcoholic and non-alcoholic fermented fruit beverages in terms of chemical and nutritional profiles that impact on human health, considering the natural occurrence and enrichment of fermented fruit-based beverages in phenolic compounds, vitamins and minerals, and pro/prebiotics. The health benefits of fruit-based beverages that resulted from lactic, acetic, alcoholic, or symbiotic fermentation and specific daily recommended doses of each claimed bioactive compound were also highlighted. The latest trends on pre-fermentative methods used to optimize the extraction of bioactive compounds (maceration, decoction, and extraction assisted by supercritical fluids, microwave, ultrasound, pulsed electric fields, high pressure homogenization, or enzymes) are critically assessed. As such, optimized fermentation processes and post-fermentative operations, reviewed in an industrial scale-up, can prolong the shelf life and the quality of fermented fruit beverages.
Genotyping-by-Sequencing Derived Genetic Linkage Map and Quantitative Trait Loci for Sugar Content in Onion (Allium cepa L.)
Authors: Lee Ye-Rin , Kim Cheol Woo , Han JiWon , Choi Hyun Jin , Han Koeun , Lee Eun Su , Kim Do-Sun , Lee Jundae , Siddique Muhammad Irfan , Lee Hye-Eun
Published: October 2021

Onion (2n = 2x = 16) has been a nutritional, medicinal and economically valuable vegetable crop all over the world since ancient times. To accelerate the molecular breeding in onion, genetic linkage maps are prerequisite. However, construction of genetic linkage maps of onion remains relatively rudimentary due to a large genome (about 16.3 Gbp) as well as biennial life cycle, cross-pollinated nature, and high inbreeding depression. In this study, we constructed single nucleotide polymorphism (SNP)-based genetic linkage map of onion in an F2 segregating population derived from a cross between the doubled haploid line ‘16P118’ and inbred line ‘Sweet Green’ through genotyping by sequencing (GBS). A total of 207.3 Gbp of raw sequences were generated using an Illumina HiSeq X system, and 24,341 SNPs were identified with the criteria based on three minimum depths, lower than 30% missing rate, and more than 5% minor allele frequency. As a result, an onion genetic linkage map consisting of 216 GBS-based SNPs were constructed comprising eight linkage groups spanning a genetic length of 827.0 cM. Furthermore, we identified the quantitative trait loci (QTLs) for the sucrose, glucose, fructose, and total sugar content across the onion genome. We identified a total of four QTLs associated with sucrose (qSC4.1), glucose (qGC5.1), fructose (qFC5.1), and total sugar content (qTSC5.1) explaining the phenotypic variation (R2%) ranging from 6.07–11.47%. This map and QTL information will contribute to develop the molecular markers to breed the cultivars with high sugar content in onion.
Bromelain Extract Exerts Antiarthritic Effects via Chondroprotection and the Suppression of TNF-α–Induced NF-κB and MAPK Signaling
Authors: Pothacharoen Peraphan , Chaiwongsa Rujirek , Chanmee Theerawut , Insuan Orapin , Wongwichai Thanchanok , Janchai Phornpimon , Vaithanomsat Pilanee
Published: October 2021

Bromelain, a mixture of proteases in pineapple rhizome, has beneficial biological properties. Following absorption, the compound remains biologically active in mammalian blood and tissues. Bromelain has multiple clinical and therapeutic applications because of its anti-arthritic activities. Anti-inflammation is one of the putative therapeutic effects of bromelain on osteoarthritis (OA) and rheumatoid arthritis (RA), but the molecular mechanisms in cartilage and synovial fibroblast has not been reported. Thus, in this study, interleukin (IL)-1β/oncostatin M-induced porcine cartilage and TNF-α–induced synovial fibroblast were used as the inflamed OA and RA models, respectively. The results demonstrated the chondroprotective effects of bromelain on cartilage degradation and the downregulation of inflammatory cytokine (tumor necrosis factor (TNF)-α, IL-1β, IL-6, IL-8) expression in TNF-α–induced synovial fibroblasts by suppressing NF-κB and MAPK signaling. The evidence from this study supported and explained the anti-inflammatory and analgesic effects of bromelain on arthritis in animal models and clinical studies.
Study on the Effect of Hole Size of Trombe Wall in the Presence of Phase Change Material for Different Times of a Day in Winter and Summer
Authors: Khetib Yacine , Alotaibi Abdullah Alhumaidi , Alshahri Abdullah H. , Cheraghan Goshtasp , Sharifpur Mohsen , Meyer Josua P.
Published: October 2021

In this article, a numerical study is performed on a Trobme wall in a tropical city for two seasons, summer and winter. A 1×1.5 m Trobme wall with a thickness of 15 cm is designed and analyzed. A 1-inch-diameter tube filled with PCM is used to enhance efficiency. The wall is analyzed at different times of the day for the two cold and hot seasons for different sizes of wall holes in the range of 70 to 17.5 cm when the wall height is 20 cm. A fluid simulation software is employed for the simulations. The problem variables include different hours of the day in the two cold and hot seasons, the presence or absence of PCM, as well as the size of the wall hole. The results of this simulation demonstrate that the maximum outlet temperature of the Trobme wall occurs at 2 P.M. Using PCM on the wall can allow the wall to operate for longer hours in the afternoon. However, the use of PCM reduces the outlet wall temperature in the morning. The smaller the size of the wall hole, the more air can be expelled from the wall.
A Selection Flowchart for Micromodel Experiments Based on Computational Fluid Dynamic Simulations of Surfactant Flooding in Enhanced Oil Recovery
Authors: Céspedes Santiago , Molina Alejandro , Lerner Betiana , Pérez Maximiliano S. , Franco Camilo A. , Cortés Farid B.
Published: October 2021

A selection flowchart that assists, through Computational Fluid Dynamics (CFD) simulations, the design of microfluidic experiments used to distinguish the performance in Chemical Enhanced Oil Recovery (CEOR) of two surfactants with very similar values of interfacial tension (IFT) was proposed and its use demonstrated. The selection flowchart first proposes an experimental design for certain modified variables (X→: porosity, grain shape, the presence of preferential flowing channels, and injection velocity). Experiments are then performed through CFD simulations to obtain a set of response variables (Y→: recovery factor, breakthrough time, the fractal dimension of flow pattern, pressure drop, and entrapment effect). A sensitivity analysis of Y→ regarding the differences in the interfacial tension (IFT) can indicate the CFD experiments that could have more success when distinguishing between two surfactants with similar IFTs (0.037 mN/m and 0.045 mN/m). In the range of modifiable variables evaluated in this study (porosity values of 0.5 and 0.7, circular and irregular grain shape, with and without preferential flowing channel, injection velocities of 10 ft/day and 30 ft/day), the entrapment effect is the response variable that is most affected by changes in IFT. The response of the recovery factor and the breakthrough time was also significant, while the fractal dimension of the flow and the pressure drop had the lowest sensitivity to different IFTs. The experimental conditions that rendered the highest sensitivity to changes in IFT were a low porosity (0.5) and a high injection flow (30 ft/day). The response to the presence of preferential channels and the pore shape was negligible. The approach developed in this research facilitates, through CFD simulations, the study of CEOR processes with microfluidic devices. It reduces the number of experiments and increases the probability of their success.
Novel Insights on the Sustainable Wet Mode Fractionation of Black Soldier Fly Larvae (Hermetia illucens) into Lipids, Proteins and Chitin
Authors: Ravi Harish Karthikeyan , Guidou Côme , Costil Jérôme , Trespeuch Christophe , Chemat Farid , Vian Maryline Abert
Published: October 2021

The black soldier fly larvae (BSFL) is a sustainable ingredient for feed applications, biofuels, composite materials and other biobased products. Processing BSFL to obtain lipid and protein fractions with enhanced functional properties as a suitable replacement for conventional feed ingredients has gained considerable momentum. In this regard, a novel and sustainable wet mode fractionation (WMF) scheme for BSFL was explored. Fresh BSFL were steam blanched and pulped to obtain BSFL juice and juice press cake. Subsequent treatment of BSFL juice employing homogenization or enzyme incubation and further centrifugation resulted in the obtention of four different BSFL fractions (Lipid—LF; Cream—CF; Aqueous—AF; and Solid—SF). Total energy consumption for a batch BSFL (500 g) WMF process was 0.321 kWh. Aqueous and solid fractions were the predominant constituents of BSFL juice. Lauric acid (44.52–49.49%) and linoleic acid (19.12–20.12%) were the primary fatty acids present in BSFL lipids. Lipid hydrolysis was observed in lipids belonging to the solid (free fatty acids > triacylglycerides) and cream fractions. Aqueous fraction proteins (ctrl) displayed superior emulsion stability and foam capacity than other treatments. Juice press cake retained 60% of the total chitin content and the rest, 40%, was found in the solid fraction (ctrl). The material distribution of principal constituents in different fractions of the WMF process and amino acid profile was elucidated. Overall, the versatile WMF process proposed in this study involves simple unit operations to obtain functional ingredients from BSFL, which can be further explored by researchers and industry stakeholders.
Hydraulic Characteristics, Residence Time Distribution, and Flow Field of Electrochemical Descaling Reactor Using CFD
Authors: Hu Bolin , Zhang Xiaoqiang , Wang Zhaofeng , Wang Zixian , Ji Yuanfan
Published: October 2021

This paper uses computational fluid dynamics (CFD) to simulate flow field distribution inside an electrochemical descaling reactor in three dimensions. First, the reactor flow field was obtained by steady-state simulation, and the grid independence was verified. Then, the steady state of the flow field was judged to ensure the accuracy of the simulation results. Transient simulations were performed on the basis of steady-state simulations, and residence time distribution (RTD) curves were obtained by a pulse-tracing method. The effects of plate height and plate spacing on reactor hydraulic characteristics (flow state and backmixing) were investigated using RTD curves, and the results showed that increasing the plate height and decreasing the plate spacing could make the flow more similar to the plug flow and reduce the degree of backmixing in the reactor. The flow field details provided by CFD were used to analyze the reactor flow field and were further verified to obtain the distribution patterns of dead and short circuit zones. Meanwhile, information regarding pressure drops was extracted for different working conditions (490, 560, and 630 mm for pole plate height and 172.6, 129.45, and 103.56 mm for pole plate spacing), and the results showed that increasing the pole plate height and decreasing the pole plate spacing led to an increased drop in pressure. In this case, a larger pressure drop means higher energy consumption. However, increasing the pole plate height had a smaller effect on energy consumption than decreasing the pole plate spacing.
Spirituality through the Lens of Students in Higher Education
Authors: Fuertes Al , Dugan Kelley
Published: October 2021

Spirituality is an elusive concept to articulate. Not only do people define it in different ways, but all definitions somehow seem to be incomplete. In this article, eighty-eight undergraduate and graduate students from George Mason University (GMU) participated in a study to define spirituality within the context of higher education. Results of the study suggest the following theme-categories. First, spirituality is an abstract reality, which is difficult to define. Second, spirituality is a moral compass, giving direction and meaning to people; and third, spirituality and religion are not the same, but they are interrelated. Since spirituality is a fluid concept that is unique from person to person, the article recommends that institutions of higher education need to incorporate into curricula mechanisms that provide students creative expressions of learning that are experiential, critical, and reflective, including opportunities that enable students to grow and develop holistically, which includes the spiritual aspect of growth, through open spaces of conversation and dialogue, and experiential learning such as community immersion and cross-cultural exchange programs as these will help cultivate and nurture their interests and aspirations, thereby, enabling them to develop meaning and purpose in life.
Main Cathedral of Mutual Legitimation: The Church of the Russian Armed Forces as a Site of Making Power Meaningful
Authors: Kolov Bojidar
Published: October 2021

The Main Cathedral of the Russian Armed Forces emerged against the background of growing cooperation between the Kremlin and the Russian Orthodox Church. A key aspect of that re-energised relationship has been the intensified engagement of State and Church leaders in practices of mutual legitimation. This study examines the case of the new church of the Russian Armed Forces as an illustration of how the Patriarchate and the Russian Government make sense of each other’s power and positions in Russian society. Analysis of the official discourses indicates three key developments. First, both Church and State, in their own right, construct a statist and nationalist normative framework where the well-being and the greatness of “the Fatherland” is of utmost value. The two institutions legitimise each other by representing the other party as acting on behalf of this shared value. Second, the dedication of cathedral to the “Victory in the Great Patriotic War” integrates the Church into this key national narrative and simultaneously incorporates elements of the Soviet past into Russia’s “sacred memory”. Third, the involvement of the Patriarchate and the Kremlin in mutual legitimation constructs a relatively independent Church–State legitimating nexus, making popular support less necessary.
Elite Youth Soccer Players’ Sources and Types of Soccer Confidence
Authors: Greenlees Iain , Parr Aimee , Murray Sarah , Burkitt Esther
Published: October 2021

Sport confidence is a psychological characteristic considered vital for youth soccer players to possess. However, only limited research has explored the types and sources of sport confidence important to elite youth performers in professional soccer academies. Semi-structured interviews were conducted with 11 academy footballers (aged 10 or 11). Abductive hierarchical content analysis identified types of confidence to include achievement, skill execution, psychological factors, superiority to opposition and tactical awareness. Key sources of confidence identified by players were performance accomplishments, coaching, social support, and preparation. Even though the dimensions reported were similar to previous research, a number of unique sub-themes of confidence sources emerged, including pre-training/competition emotions, coach and team-mate feedback. The results demonstrate the importance of considering maturation levels and context when seeking to understand and develop confidence in youth performers.
Prevalence of Cryptosporidium in Children Under 13 Years of Age With Acute Diarrhea in Tabriz, Iran
Authors: Firouzivand Yaghoub , Garedaghi Yagoob , Hassanzadeh  Khanmiri Hamidreza
Published: October 2021

Introduction: Cryptosporidium is a coccidian parasite that causes diarrhea in animals and humans, especially children. Although several studies have been done on Cryptosporidium infection in some parts of Iran, this parasite is not examined in routine parasitological tests. Therefore, the aim of this study was to determine the frequency of Cryptosporidium infection in children with diarrhea in Tabriz, Iran. Materials and Methods: In this study, 100 fecal samples of children under 13 years of age with acute diarrhea who referred to medical diagnostic laboratories in Tabriz during 2018 were examined for Cryptosporidium infection. The samples were first concentrated by formalin-ether method and after staining with modified acid fast method, they were examined by light microscope. Results: In this study, 3 children (3%), 2 boys, 3 years old and 5 years old, and a 3-year-old girl had cryptosporidiosis. Conclusion: The results of the present study show the presence of Cryptosporidium infection in children in Tabriz. The very low percentage of infection with this parasite indicates that this parasite is not yet considered as a health problem in this area.
Sexual Transmission of Strongyloidiasis: A Case Report
Authors: Bourée Patrice , Slama Dorsaf , Usubillaga Rafael , Salmon Dominique
Published: October 2021

Some parasites, such as Trichomonas vaginalis or Sarcoptes scabiei, are sexually transmitted. However, sexual transmission of most intestinal parasites is very rare. The present study reports a case of homosexual man infected with HIV who was found to be a carrier of Strongyloides stercoralis, even though he had never traveled to the tropics. However, he had repeated sexual relations with many partners, some of whom were from endemic areas. Sexual transmission of Strongyloides stercoralis and amoebiasis due to Entamoeba histolytica is rare but has already been found in the population at risk. Therefore, this parasitosis should be sought in HIV patients complaining of digestive disorders.
Religion, Conflict and Continuity in the Early Sasanian Period
Authors: YÜCEL Muhammet
Published: October 2021

This article investigates the relationship between historical/religious memory and the perception of power in the early Sasanian period, and analyses how dynastic reflexes are formulated by religion/tradition in the new system within the context of Ardashir, Kerdir and Mani. It asserts that we can discover the relationship between the Sasanian elites and religion if we understand the factors that mobilised and remodelled their historical memories. Based on these factors, it proposes that the natural relationship established by the Sasanian dynasty during the state-building phase was fuelled by historical/traditional factors rather than by conscious political factors. Thus, the inherent links between
the representatives of power and the religious tradition in the reign of Ardashir, founder of the Sasanian state, have been consciously politicised since the reign of Shapur I.
Degradasi Ekosistem Lamun di Perairan Ahmad Rhang Manyang, Kabupaten Aceh Besar
Authors: Fazillah Muhammad Rizki , Agustiar Muhammad , Sakinah Rauzatul , Razi Nanda Muhammad , Octavina Chitra , Ulfah Maria
Published: October 2021

Ekosistem lamun merupakan salah satu ekosistem yang penting dalam pengelolaan wilayah pesisir sehingga dibutuhkan kajian-kajian sebagai acuan pengelolaan. Penelitian ini bertujuan untuk memberikan informasi terbaru sebagai acuan informasi yang berguna dalam pengelolaan dan pengambilan kebijakan yang tepat terkait kelestarian ekosistem lamun di perairan Ahmad Rhang Manyang, Kabupaten Aceh Besar. Penelitian ini menggunakan metode simple random sampling. Hasil penelitian menunjukkan bahwa terdapat 2 jenis lamun yang ditemukan yaitu Halodule pinifolia dan Halophila ovalis. Penutupan lamun tertinggi yaitu dari jenis Halodule pinifolia dengan nilai 4,70 % sedangkan jenis Halophila ovalis yaitu 0,03 %. Nilai kerapatan tertinggi dari jenis Halodule pinifolia yaitu 66,14 ind/m2, sedangkan dari jenis Halophila ovalis sebesar 0,93 ind/m2. Indeks penutupan lamun dari masing-masing spesies termasuk dalam kategori miskin/rusak.Kata kunci :  Ekosistem lamun, Halodule pinifolia, Halophila ovalis, Kerapatan lamun, Tutupan lamun.
KONSEP IDEALISME WARTAWAN DALAM INDEPENDENSI MEDIA MASSA
Authors: Fazri Anhar , Hidayati Rahma , Maulida Desi
Published: October 2021

Journalists are members of the press who play an important role in the delivery of information to the public. The important role of journalists will of course be greatly influenced by their idealistic attitudes to maintain a mindset that they think is right about the media work they do. The purpose of this study was to determine the concept of journalist idealism in the context of mass media independence. This study uses a qualitative method with a methodological approach and study approach. The informants in this study were journalists and informants related to the mass media. The results showed that technological developments and changing political conditions had a new influence on the social life of journalists themselves, especially in promoting a strong attitude of professionalism. The determination of principles by prioritizing journalistic ethics and unchanging idealism presents challenges for journalists. The mass media that moves by prioritizing the market mechanism or media capitalism will give a negative stigma to the journey of the mass media. Therefore, the mass media and journalists must be able to control themselves and the institutions so that they can run a press institution without any element of interest from certain parties.
Mapping of seasonal road transport accessibility in the Arctic region of Russia
Authors: Nokelaynen Tatiana
Published: October 2021

Transport accessibility is one of the main categories in transport research and planning of socio-economic development of territories. For Russia, which has the largest area of the northern and arctic territories, this problem is especially urgent. The presence and condition of the road network determines the territorial integrity and unity of the economic space, therefore fulfilling the most important strategic task of the spatial integration of the country.

Automobile transport in the Arctic zone of the Russian Federation is poorly developed and is characterized by a low density of the public network. Its main features are the disunity of the road network, the heterogeneous degree of transport development of the territories and the noticeable role of winter roads in the road infrastructure.

An integral part of the transport logistics of the Arctic regions of Russia are winter roads, which allow transportation in the winter season at the lowest cost. The purpose of this study is to develop a database structure and thematic mapping of automobile roads in the Arctic zone of the Russian Federation, taking into account the seasonality of their operation.

As a result of this work, a classification of winter automobile roads and ice crossings of the Arctic territories was developed and an overview map “Seasonal road transport accessibility of the Arctic region of Russia” at a scale of 1:20,000,000 was compiled. The map demonstrates the contrast between the relatively good winter transport development of the territory and summer impassability.

On the basis of statistical materials, maps “Density of all-season motorable roads” and “Level of motorization” were compiled, which give an idea of the differentiation of the regions of the Arctic zone of the Russian Federation by these indicators. A high level of motorization significantly exceeds the capacity of the existing roads. This is due to the fact that off-road transport is the only guarantor of mobility for the population of hard-to-reach settlements.
Effi cacy of splenectomy in primary immune thrombocytopenia
Authors: Soboleva O. A. , Egorova E. K. , Pustovaya E. I. , Sorkina O. M. , Sabirov K. R. , Gemdzhian E. G. , Prasolov N. V. , Danishyan K. I. , Melikyan A. L.
Published: October 2021

Introduction. Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia. Splenectomy is one the most effective treatment methods for this disorder.

Aim — to evaluate the effi cacy and safety of a splenectomy in patients with primary immune thrombocytopenia.

Subjects and methods. 111 patients (31 males, 80 females) with primary immune thrombocytopenia who were hospitalized to perform laparoscopic splenectomy were included in a prospective study conducted at the National Research Center for Hematology from 2015 to 2019. Disease duration from onset to splenectomy was from 1 month to 51 years. Response to the splenectomy, complications, and correlation with immediate preoperative platelet count were analyzed.

Results. Complete response was achieved in 79 (71.2 %) cases, a partial response was achieved in 11 (9.9 %) cases, and in 21 (18.9 %) cases there was no response. Immediate preoperative platelet count was signifi cantly higher in patients with complete response in comparison with the group with no response, median (95% CI): 47 (35–58) vs 16 (9–20), p < 0.001.

Multivariate analysis (logistic regression) was performed. According to this regression, a risk factor for an unfavorable response was detected — males > 60 years of age, p = 0.05; RR (95% CI): 2.0 (0.9–7.1). A predictor of unfavorable response was identifi ed – immediate preoperative platelet count < 23 × 109/l (cutoff point determined in ROC-analysis); p = 0.001, RR (95% CI): 2.5 (1.1–8.6). The probability of complete response was lower with the number of treatment lines prior to splenectomy (weak inverse correlation: r S = −0.30; p = 0.01). The frequency of postoperative complications was 12.6 %. According to our follow-up data, a complete response was preserved in 66/79 (83.5 %) of patients, with a follow-up of 2.7 years.

Conclusion. Splenectomy is an effective and safe treatment method for ITP. Factors of unfavorable response were identifi ed: males > 60 years of age and immediate preoperative platelet count < 23 × 109/l. It is safe to perform splenectomy regardless of effectiveness of preoperative splenectomy treatment and platelet count.
Blood groups and oncological diseases
Authors: Kalandarov R. S. , Golovkina L. L.
Published: October 2021

Introduction. The study of the possible impact of the blood group system ABO and other antigenic systems of red blood cells for cancer patients is currently directed at a number of distinct paths, including the study of changes in the expression of a group of antigens in tumors; the appearance of new antigens on tumor cells; the risk of developing tumors depending on the blood group; the possible infl uence of blood group on the prognosis of the disease, etc.

Aim — to examine the current state of the problem of the relationship between blood groups and cancer.

Main findings. There is evidence that cancer is less common in people with blood type O than in people with other blood groups of the ABO system. According to other data, this dependence is noted only for some types of cancer. In general, the results of work on this topic can be assessed as insuffi cient and sometimes contradictory.
Vaccination against COVID-19 for hematologic patients: A review of clinical guidelines
Authors: Gavrilina O. A. , Vasileva А. N.
Published: October 2021

Introduction. The COVID-19 pandemic has led to the need to accelerate the development of vaccines targeting SARSCoV-2. A large number of researchers have already confi rmed that patients with cancer have a high risk of mortality from COVID-19. Hematologic diseases and the therapy of these diseases are very heterogeneous, therefore it is expected that the immune response to infection or vaccination will be more variable in this cohort of patients. Accordingly, questions arise regarding the safety and effi cacy of vaccines in the context of immune changes caused either by the hematological disease itself or by the therapy that is administered to the patient.Aim — to summarize the current understanding of the effi cacy and safety of vaccination against the SARS-CoV-2 in patients with hemoblastosis and other hematological diseases.Basic information. Legalized COVID-19 vaccines are safe and effective for the general population. Given the high mortality rate among patients with hematological diseases, which is ten times higher than the mortality rate in the general population, vaccination is a priority for this group of patients. The current lack of clinical trial data on the effectiveness and safety of vaccines against COVID-19 in hematological patients raises a large number of questions among specialists and patients. This is also due to the fact that for most of the approved vaccines immunocompromised patients were not included in the phase III clinical trials. Thus, most patients with hematological diseases could not participate in these studies, and therefore the effectiveness and safety of vaccines against the causative agent of COVID-19 have not been thoroughly studied in this group.Current recommendations for vaccination against COVID-19 in hematological patients are based on expert opinion, including past experience of immunizing these patients against other viral infections.Conclusions. Vaccination of patients with hematological diseases and their environment (medical staff, relatives, caregivers) is one of the necessary methods to prevent high mortality from a new coronavirus infection during the COVID-19 pandemic.
Coordinated Toolpath Planning for Multi-Extruder Additive Manufacturing
Authors: Khatkar Jayant , Yoo Chanyeol , Fitch Robert , Clemon Lee , Mettu Ramgopal
Published: October 2021

We present a new algorithm for coordinating the motion of multiple extruders to increase throughput in fused filament fabrication (FFF)/fused deposition modelling (FDM) additive manufacturing. Platforms based on FFF are commonly available and advantageous to several industries, but are limited by slow fabrication time and could be could be significantly improved through efficient use of multiple extruders. We propose the coordinated toolpath planning problem for systems of extruders mounted as end-effectors on robot arms with the objective of maximising utilization and avoiding collisions. Building on the idea of dependency graphs introduced in our earlier work, we develop a planning and control framework that precomputes a set of multi-layer toolpath segments from the input model and efficiently assigns them to individual extruders such that executed toolpaths are collision-free. Our method overcomes key limitations of existing methods, including utilization loss from workspace partitioning, precomputed toolpaths subject to collisions with the partially fabricated object, and wasted motion resulting from strict layer-by-layer fabrication. We report simulation results that show a major increase in utilization compared to single- and multi-extruder methods, and favorable fabrication results using commodity hardware that demonstrate the feasibility of our method in practice.
An Adaptive Gain Tuner Based Fore-ground Calibration Algorithm of a Pipeline ADC
Authors: Chatterjee Shatadal , Roy Sounak
Published: October 2021

This brief proposes a low power mixed-signal foreground calibration algorithm of a pipeline ADC, using a digitally controlled re-configurable switched capacitor multiplying DAC (MDAC) gain controller. The proposed calibration technique forces the front-end stage MDAC gain towards its ideal value to achieve the ideal ADC output linearity. In this paper, a feedback mechanism has been employed to nullify the effect of change in MDAC gain from its ideal value by sensing a digital backend unit response. The proposed technique has been verified in 0.18 um CMOS process using the cadence virtuoso tool by simulating an 11- bit pipeline ADC which contains a 1.5-bit nonideal pipeline stage followed by a 10-bit linear back-end ADC (BE-ADC). Simulation results demonstrate the recovery of the lost linearity of a 11 bit pipeline ADC post calibration.
MOSCOW METRO OF ALENA DERGILIOVA: IMAGE OF STABILITY AND FEATURES OF CHANGE
Authors: Beschastnov Nikolay , Dergiliova Evdokia
Published: October 2021

The article focuses on the study of graphic works depicting the life of the Moscow metro, created in 1980–1990 by the Moscow artist Alyona Dergiliova. The etchings convincingly reflect the life of our people on the threshold of national historical development. In her complex, variously sized, drawn from life compositions with many figures in motion, the artist mastered the whole range of compositional and visual devices that she would use in her narrative watercolours of the 2000s. She found the contrast of the pathos in the metro interior – stations with a bustling motley crowd of Muscovites deep in themselves and rather shabby travellers from the depths of the Russian backcountry – which became the counterpoint for her further creative search for the image of Moscow. Investigation of resources, experiments in methods of taking the motion of subjects beyond the boundaries of the compositional plane, allow the series to be included in the list of artistic experiments relentlessly carried out by Dergiliova despite the years of difficulties in her creative life. The theme of ‘A Man and His City’ is apparently simple but it is resolved in a multitude of complex relationships carried from life on the squares of Moscow over to the interiors of its underground. People above and underground are the same, with their acquired strangeness, yet their psychological state in a confined space is different. The environment – albeit imperceptibly – changes people. It is vibrant all the same, but in a different way. The architecture inside the metro is closer to the person, and Dergiliova successfully uses this aspect in building her composition. The compositions include many recognizable details of architectural decor which complement the central narrative. These details are clues helping the viewer to figure out its meaning. The characteristic feature of the metro is motion, and the artist draws numerous human figures, figurative stucco elements, sculptural compositions, chips and cracks in the steps, chandeliers swinging at the arrival of the subway train – into an endless cycle. Scenes depicting the entrances to the metro is a separate theme, which is almost non-existent in Russian art. By rendering the entrances as energy hubs – breaches between the aboveground Moscow and its underground – Dergiliova fills them with particular meaning, as all these people, drawn by a skilful and confident hand, will have to squeeze into the endless corridors and noisy subway wagons rattling on rails. Careful analysis of the artist’s creation reveals the disturbing condition of the master’s soul. The condition which the masters of art were firmly in for the entire decade after the events depicted in these works.
The Liar’s Paradox – a wild interation Part II. Diphthong Aristotle-Anokhin
Authors: Menshikova Elena
Published: October 2021

There are more and more precedents with offended infants of 30–40 years old – they are not emotionally abstinent, because they are in an artificial coma of infantilism, in which ‘desire’ has replaced ‘sacrifice’, and are clearly hypocritical, which is why the Holiday of Disobedience, hanging around the planet with a blinking garland of conflicts and wars, creates a turbulent zone in which the bifurcation points are taken out – beyond the orbit of common understanding, turning Consciousness into the quietest Sphinx, producing hypotheses. The saying, willingly or unwittingly, can become a “winged missile” – and destroy the whole world, good or bad, but the theory created by the presentiment of scientific research can help keep it in health and in the flesh of a divine plan, but on one condition: while maintaining peace and the will of Consciousness – the indispensable parity of the Mind, which multiplies both entities and doubt as paradox, whose mental albatrosses format our understanding. Thus, a hypothesis based on a paradox forms the Image of the Concept, and thereby builds a fundamental frame of the worldview, without belittling the elephants, and without forgetting the whale. In our world, a liar as Caesar’s wife turns out to be beyond suspicion, and, therefore, discussion, and his figure is so transparent and nano-technological that it has long been soldered into the ‘scale of errors’ of all perception – and this is the toothless sperm whale that substituted its back for the pillars of thinking, which is why not only looms as a wise turtle, but is also perceived by a cheerful Buddha. From time to time, the whale opens its mouth – and we all find ourselves in its throat, and the liar himself is outside the Law, outside the conflict, but in the Law: in the legal field of the Absolute, who knows only the doctrine of exclusiveness and the purple of shamelessness is accustomed.
ОБ УЧАСТИИ ПЕРВОГО ПРЕЗИДЕНТА ЧР, ГЕРОЯ РОССИИ А.А. КАДЫРОВА В ВОЗРОЖДЕНИИ СФЕРЫ КУЛЬТУРЫ ЧЕЧЕНСКОЙ РЕСПУБЛИКИ
Authors: Осмаев М.К.
Published: October 2021

Статья посвящена роли первого Президента Чеченской Республики, Героя России Ахмата Абдулхамидовича Кадырова в возрождении сферы культуры и искусств ЧР в поствоенный период. Ахмат-Хаджи Кадыров считал, что основой духовного возрождения народа является возвращение к лучшим чеченским традициям, к ценностям традиционной этики и суфийской духовности, которые неразделимы в чеченской духовной культуре. До конца оставаясь на этой принципиальной позиции, А.А. Кадыров сразу после назначения его Главой Чеченской Республики уделяет большое внимание оказанию государственной поддержки процессу восстановления учреждений культуры и деятельности ведущих творческих коллективов республики. Возрождение сферы культуры всех народов Чеченской Республики и прежде всего чеченского – наиболее многочисленного – он рассматривал как важнейший фактор формирования высокой духовности нашего многонационального общества.
ИНТЕРНЕТ КАК ФЕНОМЕН КУЛЬТУРЫ
Authors: Алисханова М.Х.
Published: October 2021

В середине прошлого столетия человечество вступило в информационное общество. Переход на новую ступень в развитии человечества стал возможным благодаря развитию Всемирной паутины – Интернету. 29 октября 1969 года вошел в историю как день рождения Интернета. Имена молодых ученых Чарли Клайн, Билли Дювалль вписаны в историю Интернета как первооткрыватели.
Огромные потоки информаций породили «виртуальную реальность» и «виртуальную личность», существующие вне пределах влияния со стороны политических и социальных институтов, традиционно контролирующих ситуацию в обществе. За полувековую свою историю Интернет изменил не только мировоззрение человечества, стер границы и расстояния, но и изменил структуру человеческого общества.
Порожденные Интернетом феномены требуют своей оценки, а следовательно, научного подхода к исследованию данной проблемы.
ПАРАМЕТРЫ ВНЕШНЕГО ДЫХАНИЯ У СТУДЕНТОВ И СТУДЕНТОК ВУЗА ПОСЛЕ ВЫПОЛНЕНИЯ ДВИГАТЕЛЬНОЙ ПРОБЫ
Authors: Магомедова З.А. , Алиева Х.Х. , Темирсултанова М.Х.
Published: October 2021

Были исследованы динамические показатели внешнего дыхания у студентов и студенток вуза в покое и после выполнения двигательных проб – степ-тест и пробы Мартине. Выполнение 2-х минутного степ-теста приводит к достоверному повышению жизненной емкости легких, пиковой объемной скорости, мгновенной объемной скорости и максимальной вентиляции легких, а после выполнения пробы Мартине достоверно повысились только жизненная емкость легких и их максимальная вентиляция. Таким образом, кратковременная двигательная нагрузка вызывает достоверное повышение некоторых динамических показателей внешнего дыхания, улучшение вентиляционной функции легких. Повышение объемных скоростей потока воздуха говорит об улучшении проходимости мелких и средних бронхов. У части студентов и студенток величина динамических показателей свидетельствует о неудовлетворительном состоянии функции внешнего дыхания и плохой адаптированности к двигательным пробам.
STUDIES ON THE SUITABILITY OF ELITE MULBERRY VARIETIES AT DIFFERENT ALTITUDES OF UTTARAKHAND
Authors: K.K. Rai  , Babu Lal  , V. B. Srivastav  , A. C. Juyal  , M. Shafi Mir
Published: October 2021

Mulberry leaf is a major economic component in sericulture since the quality and quantity of leaf produced per unit area has a direct bearing on cocoon harvest, although various highly productive mulberry varieties and appropriate cultivation packages have been developed to produce a high quantum of quality leaf. Data recorded on Bio-chemical analysis viz. Total Soluble Carbohydrate (TSC) (mg/g dwt) Total Soluble Protein (TSP)(mg/g dwt) and Total Chlorophyll Content (TCC) (mg/g dwt) at all 03 sites and Bioassay studies show that 02 mulberry varieties i.e. S-140 (PPR-1) and Tr-10 were found superior to other varieties including S-146, which was taken as control under this experiment.
KEY WORDS: Mulberry Varieties, Silkworm rearing, Biochemical analysis, Bioassay.
ELIXIR Software Management Plan for Life Sciences
Authors: Alves Renato , Bampalikis Dimitrios , Castro Leyla Jael , Fernández José María , Harrow Jennifer , Kuzak Mateusz , Martin Eva , Psomopoulos Fotis E. , Via Allegra
Published: October 2021

Data Management Plans are now considered a key element of Open Science. They describe the data management life cycle for the data to be collected, processed and/or generated within the lifetime of a particular project or activity. A Software Manag ement Plan (SMP) plays the same role but for software. Beyond its management perspective, the main advantage of an SMP is that it both provides clear context to the software that is being developed and raises awareness. Although there are a few SMPs already available, most of them require significant technical knowledge to be effectively used. ELIXIR has developed a low-barrier SMP, specifically tailored for life science researchers, aligned to the FAIR Research Software principles. Starting from the Four Recommendations for Open Source Software, the ELIXIR SMP was iteratively refined by surveying the practices of the community and incorporating the received feedback. Currently available as a survey, future plans of the ELIXIR SMP include a human- and machine-readable version, that can be automatically queried and connected to relevant tools and metrics within the ELIXIR Tools ecosystem and beyond.
Penerapan Model Pembelajara cooperative Tipe Think Talk Write (TTW) dalam Upaya Meningkatkan Aktivitas dan Hasil Belajar Matematika Pada Siswa Kelas V SD Negeri 4 Seraya Barat
Authors: Astawan I Komang Sulitra
Published: October 2021

This research was conducted at SD Negeri 4 Seraya Barat. This type of research is classroom action which is carried out in two cycles. The subjects of this study were the V grade students of SD Negeri 4 Seraya Barat in the odd semester of the 2019/2020 school year, totaling 14 people. Each cycle consists of four stages of activities, namely planning, implementing actions, observing, evaluating, and reflecting. The data collected in this study are: (1) student activities, and (2) student learning outcomes. Based on the results of data analysis and discussion of this research, the following conclusions can be drawn. 1) The application of the Think Talk Write (TTW) cooperative learning model in mathematics learning can improve the learning activities of fifth grade students at SD Negeri 4 Seraya Barat in the odd semester of the 2019/2020 school year. Student learning activity in Cycle I was 10.64 while student learning activity in Cycle II was 14.43. Thus there was an increase of 3.79 from cycle I to cycle II. 2) The application of the Think Talk Write (TTW) cooperative learning model in mathematics learning can improve the learning outcomes of fifth graders at SD Negeri 4 Seraya Barat in the odd semester of the 2019/2020 school year. Student learning outcomes in cycle I were 73.93 while student learning outcomes in cycle II were 90.36, thus an increase of 16.43 from cycle I to cycle II.
Advocating world cinema’s multipolorization
Authors: Kin Man Cheong
Published: October 2021

Globalization has long had a westernized and westernizing meaning. The word “globalization” itself represents an enduring modern conflict among major Kulturkreise (cultural circles). Today, another major “non-western” major Kulturkreis, East Asia, or more specifically, China (which both suffered and benefited from a radical westernization), has reached its economic summit to become a potential new pole confronting the western world’s cultural domination. Cinema, like most fields, is of western-origin and western-dominant in most of its senses. The universality of world cinema seems to be equal to a homogeneity under western or western-origin dominance, while visual anthropology, also of western origin, can offer a self-reflexive critique for the sake of pluralizing world cinema. The author argues that a fairer solution, both for the western world and some other eventual and emerging dominant cultural powers, would be that the western world itself gives up its Eurocentric dominance while helping other main Kulturkreise establish their own poles. This could in turn maintain the western world’s importance, while ending the Euro- or Occido-centrism in the field of cinema. If (un)translatability is the reason for further globalization of world cinema, its eventual domination by which power being unknown, this essay would hence advocate for the decategorization of cinema. That is to say, to loosen its boundary and understand it as part of a “logic” within a specific (cross-)cultural background in which a film is made.
Modern trends in the development of the school history textbook
Authors: Короткова М.В.
Published: October 2021

статья посвящена теоретическим проблемам разработки современного школьного учебника истории. Автор рассматривает феномен учебника истории, классификации учебных книг, тенденции развития школьного учебника в России и за рубежом. На основе обобщения большого количества литературы по теории учебника в статье предлагаются педагогические требования к современному учебнику истории.

the article is devoted to the theoretical problems of elaboration modern schoolbook of history. The author discloses phenomenon of schoolbook of history, classification of schoolbook, tendency of development schoolbook in Russia and foreign education. On basis of learning great number of literatures about schoolbooks the author suggests pedagogic demands for modern schoolbook of history.
The images of the soviet cultural revolution in the digital space: soviet alphabet book for adults as a visual symbol of the epoch
Authors: Бучкина Е.А.
Published: October 2021

статья посвящена тому, как цифровые технологии могут помочь в работе с культурными артефактами на примере наследия культурной революции в советской России. В качестве объекта анализа выступают издававшиеся в этот период буквари для взрослых. Показаны реальные примеры их цифровизации, отмечены сложности, проблемы и пути их решения.

the author explores the question of how digital technologies can help in working with cultural artifacts on the example of the heritage of the cultural revolution in Soviet Russia. The object of analysis is the ABC books for adults published during this period. Real examples of their digitalization are shown, difficulties, problems, and ways to solve them are noted.