bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Simulation of Crystallisation in External Electric Fields: A Review
Authors: English Niall J.
Published: March 2021

Elucidating the underlying mechanisms of molecular solidification in both homo- and hetero-geneous systems is of paramount importance for a large swathe of natural phenomena (whether on Earth or throughout the Universe), as well as a whole litany of industrial processes. One lesser-studied aspect of these disorder-order transitions is the effect of external applied fields, shifting both thermodynamic driving forces and underlying kinetics, and, indeed, fundamental mechanisms themselves. Perhaps this is nowhere more apparent than in the case of externally-applied electric fields, where there has been a gradually increasing number of reports in recent years of electro-manipulated crystallisation imparted by such electric fields. Drawing motivations from both natural phenomena, state-of-the-art experiments and, indeed, industrial applications, this review focusses on how non-equilibrium molecular simulation has helped to elucidate crystallisation phenomena from a microscopic perspective, as well as offering an important, predictive molecular-design approach with which to further refine in-field-crystallisation operations.
Sport and Dental Traumatology: Surgical Solutions and Prevention
Authors: Mordini Lorenzo , Lee Po , Lazaro Ricardo , Biagi Roberto , Giannetti Luca
Published: March 2021

Trauma is a worldwide cause of millions of deaths and severe injuries every year, all over the world. Despite the limited extension of the oral region compared to the whole body, dental and oral injuries account for a fairly high percentage of all body traumas. Among head and neck traumas, dental and facial injuries are highly correlated to sport activities, and their management can be a real challenge for practitioners of any specialty. In case of trauma directed to periodontal structures, restorative and endodontic solutions may not be sufficient to achieve a definitive and long-lasting treatment. This article aims to illustrate surgical options and appliances to prevent dental injuries that may be available to the clinicians treating dental trauma involving oral soft and hard tissues.
Supporting Undergraduate STEMM Education: Perspectives from Faculty Mentors and Learning Assistants in Calculus II
Authors: Hite Rebecca , Johnson Levi , Velasco Richard Carlos L. , Williams G. Brock , Griffith Ken
Published: March 2021

In higher education, Learning Assistants (LAs)—a relatively recent evolution grounded in peer mentorship models—are gaining popularity in classrooms as universities strive to meet the needs of undergraduate learners. Unlike Teaching Assistants, LAs are undergraduate students who receive continuous training from faculty mentors in content-area coaching and pedagogical skills. As near-peers, they assist assigned groups of undergraduates (students) during class. Research on LAs suggests that they are significant in mitigating high Drop-Fail-Withdrawal rates of large enrollment undergraduate science, technology, engineering, mathematics, and medical (STEMM) courses. However, there is a dearth of description regarding the learning between LAs and STEMM faculty mentors. This paper reports on perspectives of faculty mentors and their cooperating LAs in regard to their learning relationships during a Calculus II at a research-oriented university during Spring of 2020. Using an exploratory-descriptive qualitative design, faculty (oral responses) and LAs (written responses) reflected on their relationship. Content analysis (coding) resulted in four salient categories (by faculty and LA percentages, respectively) in: Showing Care and Fostering Relationships (47%, 23%); Honing Pedagogical Skills (27%, 36%); Being Prepared for Class and Students (23%, 28%); and Developing Content Knowledge in Calculus (3%, 13%). Benefits of LAs to faculty and ways to commence LA programs at institutions are also discussed.
A Framework for Using Humanoid Robots in the School Learning Environment
Authors: Mishra Deepti , Parish Karen , Lugo Ricardo Gregorio , Wang Hao
Published: March 2021

With predictions of robotics and efficient machine learning being the building blocks of the Fourth Industrial Revolution, countries need to adopt a long-term strategy to deal with potential challenges of automation and education must be at the center of this long-term strategy. Education must provide students with a grounding in certain skills, such as computational thinking and an understanding of robotics, which are likely to be required in many future roles. Targeting an acknowledged gap in existing humanoid robot research in the school learning environment, we present a multidisciplinary framework that integrates the following four perspectives: technological, pedagogical, efficacy of humanoid robots and a consideration of the ethical implications of using humanoid robots. Further, this paper presents a proposed application, evaluation and a case study of how the framework can be used.
High Velocity Lane Keeping Control Method Based on the Non-Smooth Finite-Time Control for Electric Vehicle Driven by Four Wheels Independently
Authors: Meng Qinghua , Zhao Xin , Hu Chuan , Sun Zong-Yao
Published: March 2021

In order to improve the output response and robustness of the lane keeping controller for the electric vehicle driven by four wheels independently (EV-DFWI), the article proposes a lane keeping controller based on the non-smooth finite-time (NoS-FT) control method. Firstly, a lane keeping control (LKC) model was built for the EV-DFWI. Secondly, a tracking method and error weight superposition method to track error computing for the lane keeping control based on the LKC model are proposed according to the lane line information. Thirdly, a NoS-FT controller was constructed for lane keeping. It is proved that the NoS-FT controller can stabilize the system by the direct Lyapunov method. Finally, the simulations were carried out to verify that the NoS-FT controller can keep the vehicle running in the desired lane with the straight road, constant curvature road, varied curvature road, and S-bend road. The simulation results show that the NoS-FT controller has better effectiveness than the PID controller. The contributions of this article are that two kinds of tracking error computing methods of lane keeping control are proposed to deal with different conditions, and a Non-FT lane keeping controller is designed to keep the EV-DFWI running in the desired lane suffering external disturbances.
High Efficiency of the Removal Process of Pb(II) and Cu(II) Ions with the Use of Fly Ash from Incineration of Sunflower and Wood Waste Using the CFBC Technology
Authors: Kalak Tomasz , Cierpiszewski Ryszard , Ulewicz Małgorzata
Published: March 2021

In these research studies, fly ash (SW-FA) resulting from the incineration of sunflower (20%) and wood (80%) waste employing the circulating fluidized bed combustion (CFBC) technology was used to analyze the possibility of removing Pb(II) and Cu(II) ions in adsorption processes. Currently, great emphasis is placed on circular economy, zero waste or climate neutrality strategies. The use of low-cost SW-FA waste seems to fit well with pro-ecological, economic and energy-saving trends. Hence, this material was characterized by various techniques, such as granulation analysis, bulk density, SEM-EDX, XRD and XRF analysis, BET, BJH, thermogravimetry, zeta potential, SEM morphology and FT-IR spectrometry. As a result of the conducted research, the factors influencing the effectiveness of the adsorption process, such as adsorbent dosage, initial and equilibrium pH, initial metal concentration and contact time, were analyzed. The maximum removal efficiency were achieved at the level of 99.8% for Pb(II) and 99.6% for Cu(II), respectively. The kinetics analysis and isotherms showed that the pseudo-second-order equation and the Freundlich isotherm models better describe these processes. The experiments proved that SW-FA can act as an appropriate adsorbent for highly effective removal of lead and copper from wastewater and improvement of water quality.
Experimental and Numerical-Driven Prediction of Automotive Shredder Residue Pyrolysis Pathways toward Gaseous Products
Authors: Ślefarski Rafał , Jójka Joanna , Czyżewski Paweł , Gołębiewski Michał , Jankowski Radosław , Markowski Jarosław , Magdziarz Aneta
Published: March 2021

There has been a gradual increase in the field of parts recovery from cars that are withdrawn from use. However, the disposal of automotive shredder residue (ASR) still remains a significant problem. ASR is refuse derived fuel (RDF), which contains mainly plastics, fiber sponges, and rubbers in different proportions, and therefore a thermal treatment of selected waste samples is applied. The presented research includes thermogravimetry (TG) analysis and differential thermogravimetric (DTG) analysis, as well as a proximate and an ultimate analysis of the ASR samples. The obtained results were processed and used as an input for modelling. The numerical calculations focused on the identification of the ASR’s average composition, the raw pyrolysis process product, its dry pyrolytic gas composition, and the combustible properties of the pyrolytic gases. The TGA analysis with three heating rate levels covered the temperature range from ambient to 800 °C. The thermal decomposition of the studied samples was in three stages confirmed with three peaks observed at the temperatures 280, 470, and 670 °C. The amount of solid residue grew with the heating rates and was in the range of 27–32 wt%. The numerical calculation of the pyrolysis process showed that only 0.46 kg of dry gas were formed from 1 kg of ASR. The gas yield increased with the rising temperature, and, at the same time, its calorific value decreased from 19.22 down to 14.16 MJ/m3. This is due to the decomposition of C6+ hydrocarbons and the promotion of CO formation. The thermodynamic parameters of the combustion process for a pyrolytic gas air mixture, such as the adiabatic flame temperature and laminar flame speed, were higher than for methane and were, respectively, 2073 °C and 1.02 m/s.
Laboratory Testing of Fracture Conductivity Damage by Foam-Based Fracturing Fluids in Low Permeability Tight Gas Formations
Authors: Wilk-Zajdel Klaudia , Kasza Piotr , Masłowski Mateusz
Published: March 2021

In the case of fracturing of the reservoirs using fracturing fluids, the size of damage to the proppant conductivity caused by treatment fluids is significant, which greatly influence the effective execution of hydraulic fracturing operations. The fracturing fluid should be characterized by the minimum damage to the conductivity of a fracture filled with proppant. A laboratory research procedure has been developed to study the damage effect caused by foamed and non-foamed fracturing fluids in the fractures filled with proppant material. The paper discusses the results for high quality foamed guar-based linear gels, which is an innovative aspect of the work compared to the non-foamed frac described in most of the studies and simulations. The tests were performed for the fracturing fluid based on a linear polymer (HPG—hydroxypropyl guar, in liquid and powder form). The rheology of nitrogen foamed-based fracturing fluids (FF) with a quality of 70% was investigated. The quartz sand and ceramic light proppant LCP proppant was placed between two Ohio sandstone rock slabs and subjected to a given compressive stress of 4000–6000 psi, at a temperature of 60 °C for 5 h. A significant reduction in damage to the quartz proppant was observed for the foamed fluid compared to that damaged by the 7.5 L/m3 natural polymer-based non-foamed linear fluid. The damage was 72.3% for the non-foamed fluid and 31.5% for the 70% foamed fluid, which are superior to the guar gum non-foamed fracturing fluid system. For tests based on a polymer concentration of 4.88 g/L, the damage to the fracture conductivity by the non-foamed fluid was 64.8%, and 26.3% for the foamed fluid. These results lead to the conclusion that foamed fluids could damage the fracture filled with proppant much less during hydraulic fracturing treatment. At the same time, when using foamed fluids, the viscosity coefficient increases a few times compared to the use of non-foamed fluids, which is necessary for proppant carrying capacities and properly conducted stimulation treatment. The research results can be beneficial for optimizing the type and performance of fracturing fluid for hydraulic fracturing in tight gas formations.
Adaptive Robust Fault-Tolerant Control Design for Wind Turbines Subject to Pitch Actuator Faults
Authors: Fekih Afef , Mobayen Saleh , Chen Chih-Chiang
Published: March 2021

This paper proposes an adaptive fault tolerant control (FTC) design for a variable speed wind turbine (WT) operating in the high wind speeds region. It aims at mitigating pitch actuator faults and regulating the generator power to its rated value, thereby reducing the mechanical stress in the high wind speeds region. The proposed FTC design implements a sliding mode control (SMC) approach with an adaptation law that estimates the upper bounds of the uncertainties. System stability and uniform boundedness of the outputs was proven using the Lyapunov stability theory. The proposed approach was validated on a 5 MW three-blade wind turbine modeled using the National Renewable Energy Laboratory’s (NREL) Fatigue, Aerodynamics, Structures and Turbulence (FAST) wind turbine simulator. The controller’s performance was assessed in the presence of several pitch actuator faults and turbulent wind conditions. Its performance was also compared to that of a standard SMC approach. Mitigation of blade pitch actuator faults, generation of uniform power, smoother pitching actions and reduced chattering compared to standard SMC approach are among the main features of the proposed design.
Aspects Concerning the Fabrication of Magnetorheological Fluids Containing High Magnetization FeCo Nanoparticles
Authors: Gutiérrez Jon , Vadillo Virginia , Gómez Ainara , Berasategi Joanes , Insausti Maite , Gil de Muro Izaskun , Bou-Ali M. Mounir
Published: March 2021

Recently, our collaborative work in the fabrication of a magnetorheological fluid (MRF) containing high magnetization FeCo nanoparticles (NPs, fabricated in our laboratories using the chemical reduction technique; MS = 212 Am2/kg) as magnetic fillers have resulted in a new MRF with superior performance up to 616.7 kA/m. The MRF had a yield stress value of 2729 Pa and good reversibility after a demagnetization process. This value competes with the best ones reported in the most recent literature. Nevertheless, the fabrication process of this type of fluid is not an easy task since there is a strong trend to the aggregation of the FeCo NPs due to the strong magnetic dipolar interaction among them. Thus, now we present the analysis of some aspects concerning the fabrication process of our FeCo NPs containing MRF, mainly the type of surfactant used to cover those NPs (oleic acid or aluminium stearate) and its concentration, and the procedure followed (mechanical and/or ultrasound stirring) to achieve a good dispersion of those magnetic fillers within the fluid.
Effects of Molecular Weight and Degree of Esterification of Soluble Soybean Polysaccharide on the Stability of Casein under Acidic Conditions
Authors: Tian Hao , Zhao Qizhu , He Zhiyong , Wang Zhaojun , Qin Fang , Zeng Maomao , Chen Jie
Published: March 2021

The effects of molecular weight (MW) and degree of esterification (DE) of soluble soybean polysaccharide (SSPS) on the stability of casein under acidic conditions were investigated. The ability of SSPS to stabilize casein was characterized by the content of SSPS–casein complex, the LUMiSizer instability index, average particle size, zeta potential, and storage experiments. The long-term storage stability of the mixtures was related to their ability to combine casein and the stability of the complexes. At the same DE, SSPSs with medium MW formed more complexes with casein than SSPSs with high or low MW; and at the same MW, SSPSs with medium or low DE formed more complexes than SPSSs with high DE. In addition, SSPSs with higher MW had a better stabilizing behavior due to the large steric repulsion between complexes. SSPSs with high MW and low DE showed the best ability to stabilize casein under acid conditions.
A Theoretical Framework on the Determinants of Food Purchasing Behavior of the Elderly: A Bibliometric Review with Scientific Mapping in Web of Science
Authors: Alhammadi Khaled , Santos-Roldán Luna , Cabeza-Ramírez Luis Javier
Published: March 2021

The past few years have seen significant demographic changes in most regions, including an increased elderly population. Subsequently, elderly citizens comprise an important market segment of consumers, with the food industry one of the most affected areas in this context. However, food market managers previously believed that elderly consumers’ needs were stereotyped in nature. The lack of focus on this sector, therefore, left elderly consumers as an untapped market, without realizing the financial independence of this segment regarding their nutrition. This research will attempt to provide the key determinant factors on elderly consumers’ behavior related to food. For that purpose, a complete literature review of more than 123 papers regarding these concepts has been carried out. Once analyzed, we highlight the common insights to give clear guidance for supermarket managers and food manufacturers to have a better knowledge of the reasons behind elderly people’s food acquisitions.
Morus alba L. Plant: Bioactive Compounds and Potential as a Functional Food Ingredient
Authors: Chen Centhyea , Mohamad Razali Umi Hartina , Saikim Fiffy Hanisdah , Mahyudin Azniza , Mohd Noor Nor Qhairul Izzreen
Published: March 2021

Morus alba L. (M. alba) is a highly adaptable plant that is extensively incorporated in many traditional and Ayurveda medications. Various parts of the plant, such as leaves, fruits, and seeds, possess nutritional and medicinal value. M. alba has abundant phytochemicals, including phenolic acids, flavonoids, flavonols, anthocyanins, macronutrients, vitamins, minerals, and volatile aromatic compounds, indicating its excellent pharmacological abilities. M. alba also contains high nutraceutical values for protein, carbohydrates, fiber, organic acids, vitamins, and minerals, as well as a low lipid value. However, despite its excellent biological properties and nutritional value, M. alba has not been fully considered as a potential functional food ingredient. Therefore, this review reports on the nutrients and bioactive compounds available in M. alba leaves, fruit, and seeds; its nutraceutical properties, functional properties as an ingredient in foodstuffs, and a microencapsulation technique to enhance polyphenol stability. Finally, as scaling up to a bigger production plant is needed to accommodate industrial demand, the study and limitation on an M. alba upscaling process is reviewed.
Editorial for Special Issue “Interdisciplinary Geosciences Perspectives of Tsunami Volume 3”
Authors: Suppasri Anawat
Published: March 2021

Disaster-related research has its own interdisciplinary perspectives connected to the disaster cycle (response, recovery, prevention, and preparedness) [...]
Shedding Light on the Direct and Indirect Impact of the COVID-19 Pandemic on the Lebanese Radiographers or Radiologic Technologists: A Crisis within Crises
Authors: Itani Rasha , Alnafea Mohammed , Tannoury Maya , Hallit Souheil , Al Faraj Achraf
Published: March 2021

With the novel coronavirus disease 2019 (COVID-19) pandemic, the need for radiologic procedures is increasing for the effective diagnosis and follow-up of pulmonary diseases. There is an immense load on the radiographers’ shoulders to cope with all the challenges associated with the pandemic. However, amidst this crisis, Lebanese radiographers are also suffering from a socioeconomic crisis and record hyperinflation that have posed additional challenges. A cross-sectional study was conducted among registered Lebanese radiographers to assess the general, workplace conditions, health and safety, mental/psychologic, financial, and skill/knowledge development impacts. Despite applying an adapted safety protocol, institutions are neither providing free RT-PCR testing to their staff nor showing adequate support for infected staff members, thus causing distress about contracting the virus from the workplace. Aggravated by the deteriorating economic situation that affected the radiographers financially, they additionally suffer from severe occupational physical and mental burnout. Regardless of that, they used their free time during the lockdown for skill/knowledge development and have performed many recreational activities. This cross-sectional study highlighted the different ways the pandemic has impacted the radiographers: physically, psychologically, and financially. It aimed to shed light on what these frontline heroes are passing through in the midst of all these unprecedented crises.
The Association between Quitline Characteristics and Smoking Cessation by Educational Attainment, Income, Race/Ethnicity, and Sex
Authors: Colston David C. , Simard Bethany J. , Xie Yanmei , McLeod Marshall Chandler , Elliott Michael R. , Thrasher James F. , Fleischer Nancy L.
Published: March 2021

Little research examines how tobacco quitlines affect disparities in smoking cessation in the United States. Our study utilized data from the Tobacco Use Supplement to the Current Population Survey (2010, 2011, 2012, 2015, 2018) (TUS-CPS) and state-level quitline data from the North American Quitline Consortium and National Quitline Data Warehouse. We ran multilevel logistic regression models assessing a state-run quitline’s budget, reach, number of counseling sessions offered per caller, and hours of operation on 90-day smoking cessation. Multiplicative interactions between all exposures and sex, race/ethnicity, income, and education were tested to understand potential effect modification. We found no evidence that budget, reach, number of counseling sessions, or hours available for counseling were associated with cessation in the main effects analyses. However, when looking at effect modification by sex, we found that higher budgets were associated with greater cessation in males relative to females. Further, higher budgets and offering more sessions had a stronger association with cessation among individuals with lower education, while available counseling hours were more strongly associated with cessation among those with higher education. No quitline characteristics examined were associated with smoking cessation. We found evidence for effect modification by sex and education. Despite proven efficacy at the individual-level, current resource allocation to quitlines may not be sufficient to improve rates of cessation.
Health Literacy, Digital Health Literacy, and COVID-19 Pandemic Attitudes and Behaviors in U.S. College Students: Implications for Interventions
Authors: Patil Uday , Kostareva Uliana , Hadley Molly , Manganello Jennifer A. , Okan Orkan , Dadaczynski Kevin , Massey Philip M. , Agner Joy , Sentell Tetine
Published: March 2021

The COVID-19 pandemic has been accompanied by rapidly emerging evidence, changing guidance, and misinformation, which present new challenges for health literacy (HL) and digital health literacy (DHL) skills. This study explored whether COVID-19-related information access, attitudes, and behaviors were associated with health literacy and digital health literacy among college students in the United States. Self-reported measures of health literacy, along with items on pandemic-related attitudes, behaviors, information sources, and social networks, were collected online using a managed research panel. In July 2020, 256 responses were collected, which mirrored the racial/ethnic and gender diversity of U.S. colleges. Only 49% reported adequate HL, and 57% found DHL tasks easy overall. DHL did not vary by HL level. In multivariable models, both HL and DHL were independently associated with overall compliance with basic preventive practices. Higher DHL, but not HL, was significantly associated with greater willingness to get a COVID-19 vaccine and the belief that acquiring the disease would negatively impact their life. On average, respondents discussed health with 4–5 people, which did not vary by HL or DHL measures. The usage of online information sources varied by HL and DHL. The study findings can inform future student-focused interventions, including identifying the distinct roles of HL and DHL in pandemic information access, attitudes, and behaviors.
Mental Health, Greenness, and Nature Related Behaviors in the Adult Population of Stockholm County during COVID-19-Related Restrictions
Authors: Lõhmus Mare , Stenfors Cecilia U. D. , Lind Tomas , Lauber André , Georgelis Antonios
Published: March 2021

International data suggest that exposure to nature is beneficial for mental health and well-being. The restrictions related to the COVID-19 pandemic have created a setting that allows us to investigate the importance of greenness exposure on mental health during a period of increased isolation and worry. Based on 2060 responses from an online survey in Stockholm County, Sweden, we investigated: (1) whether the COVID-19 pandemic changed peoples’ lifestyle and nature-related habits, and (2) if peoples’ mental health differed depending on their exposure to greenness. Neighborhood greenness levels were quantified by using the average normalized difference vegetation index (NDVI) within 50 m, 100 m, 300 m, and 500 m buffers surrounding the participant’s place of residence. We found that the number of individuals that reported that they visited natural areas “often” was significantly higher during the pandemic than before the pandemic. Higher levels of greenness surrounding one’s location of residence were in general associated with higher mental health/well-being and vitality scores, and less symptoms of depression, anxiety, and perceived and cognitive stress, after adjustments for demographic variables and walkability. In conclusion, the results from the present study provided support to the suggestion that contact with nature may be important for mental health in extreme circumstances.
Lessons Learned from Replicating a Randomized Control Trial Evaluation of an App-Based Sexual Health Program
Authors: Manlove Jennifer , Whitfield Brooke , Finocharo Jane , Cook Elizabeth
Published: March 2021

This study presents findings from a randomized control trial replication evaluation of Pulse, an app-based pregnancy prevention program implemented with Black and Latinx women aged 18–20, a population with high rates of unplanned pregnancy. We used social media advertisements to enroll 1013 women online across the U.S. and automatically randomized participants to either the Pulse reproductive health app or a general health control app, stratifying by age and race/Latinx ethnicity. Participants received reminder text messages to view the app as well as text messages with app-related content throughout the intervention. Linear probability models were conducted on the analytic sample of 871 participants who completed the six-week survey and 798 who completed the six-month survey and adjusted for permuted block randomization and multiple hypothesis testing. Compared to the control group, intervention group participants had higher contraceptive knowledge (p = 0.000), which replicates findings from an earlier evaluation. However, these impacts were not sustained at six-month follow-up (p = 0.162). We found no other significant program impacts. This contrasts with an earlier evaluation that found intervention participants were less likely to have had sex without a hormonal or long-acting reversible contraceptive (LARC) method and had greater self-confidence to use contraception consistently than the control group. Different demographic characteristics, lower app usage, and more negative attitudes about and usage of hormonal/LARC contraception in the current sample may help to explain fewer impacts than the earlier evaluation.
Life Satisfaction and Adaptation in Persons with Parkinson’s Disease—A Qualitative Study
Authors: Rosengren Lina , Forsberg Anna , Brogårdh Christina , Lexell Jan
Published: March 2021

Persons with Parkinson’s disease (PD) need to adapt to their progressive disability to achieve and maintain a high degree of life satisfaction (LS), but little is known about the meaning of LS and adaptation. This study aimed to gain an in-depth understanding of the meaning of LS and adaptation in persons with PD. Open-ended in-depth interviews were performed with 13 persons diagnosed with PD, 9 women, 3 men, and one non-binary person (mean age 54 years, mean time since diagnosis 3.4 years). The interviews were analyzed using a phenomenological–hermeneutic approach. The participants were in the process of adapting to their new health situation. There were two quite distinct groups: one that adapted through acceptance and one that struggled to resist the disease and the profound impact it had on their lives. The thematic structural analysis covers eight themes illustrating the meaning of LS and adaptation, through either acceptance or resistance. Adaptation to PD involves a transitional process characterized by either acceptance or resistance, which influences a person’s LS. Acceptance makes LS possible, whereas resistance constitutes a behavioral barrier to adaptation and LS. Rehabilitation professionals need to understand this individual process to be able to support a person with PD to reach and maintain a high level of LS. Understanding the link between LS and adaptation can support rehabilitation professionals to provide targeted interventions for people with PD.
Fowler’s Syndrome—The Cause of Urinary Retention in Young Women, Often Forgotten, but Significant and Challenging to Treat
Authors: Szymański Jacek K. , Słabuszewska-Jóźwiak Aneta , Jakiel Grzegorz
Published: March 2021

Urinary retention in young women is a relatively rare clinical problem and is often underdiagnosed. In particular, functional causes of urinary retention pose a diagnostic challenge. One of them is Fowler’s syndrome, which is associated with impaired urethral relaxation. Fowler’s syndrome is characterized by a large bladder capacity, reduced sensation, increased maximal urethral closure pressure, and detrusor underactivity. Several hypotheses have arisen to explain the cause of urethral relaxation disorders: hormonal changes characteristic of Polycystic Ovary Syndrome (PCOS), causing abnormal stabilization of the muscle membrane, primary failure of relaxation of the striated muscle of the urethra sphincter, and increased urethral afferent activity, inhibiting the bladder afferent signals from reaching the brain by potentiating a spinal mechanism of urinary continence. Currently, sacral neuromodulation is the only intervention that can restore an atypical voiding pattern in women with Fowler’s syndrome. The therapeutic effectiveness exceeds 70%, although the revision rate is relatively high, exceeding 50%. Well-designed, long-term prospective studies comparing sacral neuromodulation (SNM) with other therapies such as pelvic floor muscle physiotherapy are warranted to offer the best patient-tailored treatment.
Lifestyle Habits and Mental Health in Light of the Two COVID-19 Pandemic Waves in Sweden, 2020
Authors: Blom Victoria , Lönn Amanda , Ekblom Björn , Kallings Lena V. , Väisänen Daniel , Hemmingsson Erik , Andersson Gunnar , Wallin Peter , Stenling Andreas , Ekblom Örjan , Lindwall Magnus , Salier Eriksson Jane , Holmlund Tobias , Ekblom-Bak Elin
Published: March 2021

The COVID-19 pandemic has become a public health emergency of international concern, which may have affected lifestyle habits and mental health. Based on national health profile assessments, this study investigated perceived changes of lifestyle habits in response to the COVID-19 pandemic and associations between perceived lifestyle changes and mental health in Swedish working adults. Among 5599 individuals (50% women, 46.3 years), the majority reported no change (sitting 77%, daily physical activity 71%, exercise 69%, diet 87%, alcohol 90%, and smoking 97%) due to the pandemic. Changes were more pronounced during the first wave (April–June) compared to the second (October–December). Women, individuals <60 years, those with a university degree, white-collar workers, and those with unhealthy lifestyle habits at baseline had higher odds of changing lifestyle habits compared to their counterparts. Negative changes in lifestyle habits and more time in a mentally passive state sitting at home were associated with higher odds of mental ill-health (including health anxiety regarding one’s own and relatives’ health, generalized anxiety and depression symptoms, and concerns regarding employment and economy). The results emphasize the need to support healthy lifestyle habits to strengthen the resilience in vulnerable groups of individuals to future viral pandemics and prevent health inequalities in society.
A School-Level Examination of the Association between Programs and Policies and Physical Activity Outcomes among Females from the COMPASS Study
Authors: Burns Kathleen E. , Vermeer Julianne , Battista Kate , Leatherdale Scott T.
Published: March 2021

(1) The majority of Canadian youth are not meeting physical activity guidelines, and more female than male youth are falling short of these recommendations. School programs and policies are a viable strategy to improve youth physical activity. However, they may differentially affect female and male activity. This study aimed to examine school-level differences in physical activity outcomes among male and female students and to explore how school programs and policies associate with school-level physical activity outcomes among females. (2) This study used data from 136 schools participating in year 7 (Y7 2018–2019) of the COMPASS study. Data on school programs and policies and on student physical activity were collected. School-level means and percentages for outcomes were calculated and compared between males and females and the impact of physical activity programs and policies on female physical activity outcomes were examined. (3) More males met the guidelines, achieved more strength training days and physical activity minutes compared to females. The number of female varsity sports, community partnerships and fitness ambassadors were all positively and significantly associated with female physical activity. (4) Supportive physical activity environments fostered by offering varsity sports, establishing community partnerships and positive role models may promote physical activity among female youth.
Association between Bullying Victimization and Symptoms of Depression among Adolescents: A Moderated Mediation Analysis
Authors: Mei Songli , Hu Yueyang , Sun Mengzi , Fei Junsong , Li Chuanen , Liang Leilei , Hu Yuanchao
Published: March 2021

Background: Bullying victimization and its effect on symptoms of depression have received attention from researchers, but few studies have considered the potential mechanism. The aim of this study was to examine a moderated mediation model for the association between bullying victimization and depressive symptoms in terms of it being mediated by social anxiety, and investigated whether sleep duration would show moderating effects in this relationship. Methods: In this study, there were 2956 students, who completed three questionnaires, including a bullying victimization scale, as well as a social anxiety and epidemiologic studies depression scale. Results: Bullying victimization’s effects on depressive symptoms were mediated by social anxiety. Furthermore, sleep duration moderated the relationship between bullying victimization and depressive symptoms. Conclusions: The research contributes by clarifying the mechanisms underlying the relationship between bullying victimization and depressive symptoms.
Prediction of Type 2 Diabetes Based on Machine Learning Algorithm
Authors: Deberneh Henock M. , Kim Intaek
Published: March 2021

Prediction of type 2 diabetes (T2D) occurrence allows a person at risk to take actions that can prevent onset or delay the progression of the disease. In this study, we developed a machine learning (ML) model to predict T2D occurrence in the following year (Y + 1) using variables in the current year (Y). The dataset for this study was collected at a private medical institute as electronic health records from 2013 to 2018. To construct the prediction model, key features were first selected using ANOVA tests, chi-squared tests, and recursive feature elimination methods. The resultant features were fasting plasma glucose (FPG), HbA1c, triglycerides, BMI, gamma-GTP, age, uric acid, sex, smoking, drinking, physical activity, and family history. We then employed logistic regression, random forest, support vector machine, XGBoost, and ensemble machine learning algorithms based on these variables to predict the outcome as normal (non-diabetic), prediabetes, or diabetes. Based on the experimental results, the performance of the prediction model proved to be reasonably good at forecasting the occurrence of T2D in the Korean population. The model can provide clinicians and patients with valuable predictive information on the likelihood of developing T2D. The cross-validation (CV) results showed that the ensemble models had a superior performance to that of the single models. The CV performance of the prediction models was improved by incorporating more medical history from the dataset.
Through the Looking Glass of Social Media. Focus on Self-Presentation and Association with Mental Health and Quality of Life. A Cross-Sectional Survey-Based Study
Authors: Skogen Jens Christoffer , Hjetland Gunnhild Johnsen , Bøe Tormod , Hella Randi Træland , Knudsen Ann Kristin
Published: March 2021

Social media (SOME) use among adolescents has been linked to mental health and well-being. SOME self-presentation has been highlighted as an important factor to better understand the potential links. The aims of this study were to investigate the association between focus on SOME self-presentation and mental health and quality of life among adolescents. We used a cross-sectional survey, with n = 513 (56%; mean age 17.1 years; 58% boys) students from a senior high school in Norway. Associations between focus on SOME self-presentation and symptoms of anxiety and depression and quality of life were investigated using blobbograms, standardized mean difference (SMD), and gender-specific linear regression models. A high focus on SOME self-presentation was associated with more mental health problems and reduced quality of life. The strength of the associations with symptoms of depression (0.75SMD) and anxiety (0.71SMD) was large, while it was medium-large for quality of life (−0.58SMD). The association was similar across gender in relation to symptoms of anxiety. For symptoms of depression and quality of life, the association was stronger for girls compared to boys. Our findings yield preliminary evidence of a potential relationship between focus on SOME self-presentation and mental health.
Associations between Well-Being State and Match External and Internal Load in Amateur Referees
Authors: Ozaeta Eñaut , Yanci Javier , Castagna Carlo , Romaratezabala Estibaliz , Castillo Daniel
Published: March 2021

The main aim of this paper was to examine the association between prematch well-being status with match internal and external load in field (FR) and assistant (AR) soccer referees. Twenty-three FR and 46 AR participated in this study. The well-being state was assessed using the Hooper Scale and the match external and internal loads were monitored with Stryd Power Meter and heart monitors. While no significant differences were found in Hooper indices between match officials, FR registered higher external loads (p < 0.01; ES: 0.75 to 5.78), spent more time in zone 4 and zone 5, and recorded a greater training impulse (TRIMP) value (p < 0.01; ES: 1.35 to 1.62) than AR. Generally, no associations were found between the well-being variables and external loads for FR and AR. Additionally, no associations were found between the Hooper indices and internal loads for FR and AR. However, several relationships with different magnitudes were found between internal and external match loads, for FR, between power and speed with time spent in zone 2 (p < 0.05; r = −0.43), ground contact time with zone 2 and zone 3 (p < 0.05; r = 0.50 to 0.60) and power, speed, cadence and ground contact time correlated with time spent in zone 5 and TRIMP (p < 0.05 to 0.01; r = 0.42 to 0.64). Additionally, for AR, a relationship between speed and time in zone 1 was found (p < 0.05; r = −0.30; CL = 0.22). These results suggest that initial well-being state is not related to match officials’ performances during match play. In addition, the Stryd Power Meter can be a useful device to calculate the external load on soccer match officials.
Rice PIN Auxin Efflux Carriers Modulate the Nitrogen Response in a Changing Nitrogen Growth Environment
Authors: Gho Yun-Shil , Song Min-Yeong , Bae Do-Young , Choi Heebak , Jung Ki-Hong
Published: March 2021

Auxins play an essential role in regulating plant growth and adaptation to abiotic stresses, such as nutrient stress. Our current understanding of auxins is based almost entirely on the results of research on the eudicot Arabidopsis thaliana, however, the role of the rice PIN-FORMED (PIN) auxin efflux carriers in the regulation of the ammonium-dependent response remains elusive. Here, we analyzed the expression patterns in various organs/tissues and the ammonium-dependent response of rice PIN-family genes (OsPIN genes) via qRT–PCR, and attempted to elucidate the relationship between nitrogen (N) utilization and auxin transporters. To investigate auxin distribution under ammonium-dependent response after N deficiency in rice roots, we used DR5::VENUS reporter lines that retained a highly active synthetic auxin response. Subsequently, we confirmed that ammonium supplementation reduced the DR5::VENUS signal compared with that observed in the N-deficient condition. These results are consistent with the decreased expression patterns of almost all OsPIN genes in the presence of the ammonium-dependent response to N deficiency. Furthermore, the ospin1b mutant showed an insensitive phenotype in the ammonium-dependent response to N deficiency and disturbances in the regulation of several N-assimilation genes. These molecular and physiological findings suggest that auxin is involved in the ammonium assimilation process of rice, which is a model crop plant.
Mitochondrial Transfer in Cancer: A Comprehensive Review
Authors: Zampieri Luca X. , Silva-Almeida Catarina , Rondeau Justin D. , Sonveaux Pierre
Published: March 2021

Depending on their tissue of origin, genetic and epigenetic marks and microenvironmental influences, cancer cells cover a broad range of metabolic activities that fluctuate over time and space. At the core of most metabolic pathways, mitochondria are essential organelles that participate in energy and biomass production, act as metabolic sensors, control cancer cell death, and initiate signaling pathways related to cancer cell migration, invasion, metastasis and resistance to treatments. While some mitochondrial modifications provide aggressive advantages to cancer cells, others are detrimental. This comprehensive review summarizes the current knowledge about mitochondrial transfers that can occur between cancer and nonmalignant cells. Among different mechanisms comprising gap junctions and cell-cell fusion, tunneling nanotubes are increasingly recognized as a main intercellular platform for unidirectional and bidirectional mitochondrial exchanges. Understanding their structure and functionality is an important task expected to generate new anticancer approaches aimed at interfering with gains of functions (e.g., cancer cell proliferation, migration, invasion, metastasis and chemoresistance) or damaged mitochondria elimination associated with mitochondrial transfer.
Ablation of Acid Ceramidase Impairs Autophagy and Mitochondria Activity in Melanoma Cells
Authors: Lai Michele , La Rocca Veronica , Amato Rachele , Freer Giulia , Costa Mario , Spezia Pietro Giorgio , Quaranta Paola , Lombardo Giuseppe , Piomelli Daniele , Pistello Mauro
Published: March 2021

Cutaneous melanoma is often resistant to therapy due to its high plasticity, as well as its ability to metabolise chemotherapeutic drugs. Sphingolipid signalling plays a pivotal role in its progression and metastasis. One of the ways melanoma alters sphingolipid rheostat is via over-expression of lysosomal acid ceramidase (AC), which catalyses the hydrolysis of pro-apoptotic long-chain ceramides into sphingosine and fatty acid. In this report, we examine the role of acid ceramidase in maintaining cellular homeostasis through the regulation of autophagy and mitochondrial activity in melanoma cell lines. We show that under baseline conditions, wild-type melanoma cells had 3-fold higher levels of the autophagy marker, microtubule-associated proteins 1A/1B light chain 3B (LC3 II), compared to AC-null cells. This difference was further magnified after cell starvation. Moreover, we noticed autophagy impairment in A375 AC-null cells, possibly due to local accumulation of non-metabolized ceramides. Nonetheless, we observed that AC-null cells exhibited a significant increase in mitochondrial membrane potential compared to control cells. Consistent with this observation, we found that, after total starvation, ~30% of AC-null cells undergo apoptosis compared to ~6% of wild-type cells. As expected, AC transfection restored viability in A375 AC-null cells. Together, these findings suggest that AC-null melanoma cells change and adapt their metabolism to survive in the absence of AC, although in a way that does not allow them to cope with the stress of nutrient deprivation.
Synthesis of New Water Soluble β-Cyclodextrin@Curcumin Conjugates and In Vitro Safety Evaluation in Primary Cultures of Rat Cortical Neurons
Authors: Ben Mihoub Amina , Acherar Samir , Frochot Céline , Malaplate Catherine , Yen Frances T. , Arab-Tehrany Elmira
Published: March 2021

Self-aggregation of Curcumin (Cur) in aqueous biological environment decreases its bioavailability and in vivo therapeutic efficacy, which hampers its clinical use as candidate for reducing risk of neurodegenerative diseases. Here, we focused on the design of new Cur- β-Cyclodextrin nanoconjugates to improve the solubility and reduce cell toxicity of Cur. In this study, we described the synthesis, structural characterization, photophysical properties and neuron cell toxicity of two new water soluble β-CD/Cur nanoconjugates as new strategy for reducing risks of neurodegenerative diseases. Cur was coupled to one or two β-CD molecules via triazole rings using CuAAC click chemistry strategy to yield β-CD@Cur and (β-CD)2@Cur nanoconjugates, respectively. The synthesized nanoconjugates were found to be able to self-assemble in aqueous condition and form nano-aggregates of an average diameter size of around 35 and 120 nm for β-CD@Cur and (β-CD)2@Cur, respectively. The photophysical properties, water solubility and cell toxicity on rat embryonic cortical neurons of the designed nanoconjugates were investigated and compared to that of Cur alone. The findings revealed that both new nanoconjugates displayed better water solubility and in vitro biocompatibility than Cur alone, thus making it possible to envisage their use as future nano-systems for the prevention or risk reduction of neurodegenerative diseases.