bluuebunny/crossref_metadata_2025 huggingface dataset:
Adaptive, Iterative, Long-Term Personalized Therapy Management in a Case of Stage IV Refractory NSCLC
Authors: Ranade Anantbhushan , Patil Darshana , Bhatt Amit , Dhasare Rucha , Datta Vineet , Datar Rajan , Akolkar Dadasaheb
Published: July 2019

In this paper we report long-term therapy management based on iterative de novo molecular and cellular analysis in a case of metastatic non-small cell lung cancer (NSCLC), with prior history of treated colorectal cancer. In the described case temporal tumor evolution, emergent therapy resistance and disease recurrences were addressed via the administration of personalized label- and organ-agnostic treatments based on de novo tumor profiling. This adaptive and iterative treatment strategy countered disease progression at each instance and led to the durable regression of primary as well as metastatic lesions. Concurrently, serial evaluation of mutations in cell-free circulating tumor DNA (ctDNA) via liquid biopsy (LBx) was performed to monitor disease status, ascertain treatment response, identify emergent drug resistance and detect recurrence at sub-radiological levels. The treatment management strategy described herein effectively addressed multiple, sequential clinical conundrums for which viable options were unavailable under the current Standard of Care (SoC).
N-(Isobutyl)-3,4-methylenedioxy Cinnamoyl Amide
Authors: Dofuor Aboagye Kwarteng , Kwain Samuel , Osei Enoch , Mawuli Tetevi Gilbert , Okine Laud Kenneth , Ohashi Mitsuko , Gwira Theresa Manful , Kyeremeh Kwaku
Published: July 2019

The plant Zanthoxylum zanthoxyloides (Lam.) Zepern. & Timler is one of the most important medicinal species of the genus Zanthoxylum on the African continent. It is used in the treatment and management of parasitic diseases in sub-Saharan Africa. These properties have inspired scientists to investigate species within the genus for bioactive compounds. However, a study, which details a spectroscopic, spectrometric and bioactivity guided extraction and isolation of antiparasitic compounds from the genus Zanthoxylum is currently non-existent. Tortozanthoxylamide (1), which is a derivative of the known compound armatamide was isolated from Z. zanthoxyloides and the full structure determined using UV, IR, 1D/2D-NMR and high-resolution liquid chromatography tandem mass spectrometry (HRESI-LC-MS) data. When tested against Trypanosoma brucei subsp. brucei, the parasite responsible for animal African trypanosomiasis in sub-Saharan Africa, 1 (IC50 7.78 µM) was just four times less active than the commercially available drug diminazene aceturate (IC50 1.88 µM). Diminazene aceturate is a potent drug for the treatment of animal African trypanosomiasis. Tortozanthoxylamide (1) exhibits a significant antitrypanosomal activity through remarkable alteration of the cell cycle in T. brucei subsp. brucei, but it is selectively non-toxic to mouse macrophages RAW 264.7 cell lines. This suggests that 1 may be considered as a scaffold for the further development of natural antitrypanosomal compounds.
3D Human Periodontal Stem Cells and Endothelial Cells Promote Bone Development in Bovine Pericardium-Based Tissue Biomaterial
Authors: Pizzicannella Jacopo , Pierdomenico Sante D. , Piattelli Adriano , Varvara Giuseppe , Fonticoli Luigia , Trubiani Oriana , Diomede Francesca
Published: July 2019

Bone defects repair represents a public and urgent problem in clinical practice, in fact, every year, more than two million patients required new treatments for bone injuries. Today a complete vascularization is strategic in bone formation, representing a new frontier for clinical application. Aim of this research has been developed a three-dimensional (3D) coculture platform using a bovine pericardium collagen membrane (BioR) loaded with human periodontal ligament stem cells (hPDLSCs) and endothelial differentiated cells from hPDLSCs (E-hPDLSCs) able to undergo toward osteoangiogenesis differentiation process. First, we have characterized at confocal laser scanning microscopy (CLSM) level the E-hPDLSCs phenotype profile, through CD31 and CD34 markers expression and the ability to tube vessel formation. Real Time-Polimerase Chain Reaction (RT-PCR) and western blotting analyses revealed the upregulation of Runt-related transcription factor 2 (RUNX2), Collagen 1A1 (COL1A1), Vascular Endothelial Growth Factor-A (VEGF-A) genes and proteins in the living construct composed by hPDLSCs + E-hPDSCs/BioR. Human PDLSCs + E-hPDLSCs/BioR construct showed also an enhacement of de novo synthesis of osteocalcin. Given that, the extracellular-signal-regulated kinase (ERK)/mitogen activated protein kinase (MAPK) transduction signaling was involved in the osteogenesis and angiogenesis process, the ERK1/2 protein level at biochemical level, in our experimental model, has been investigated. Our results evidenced an upregulation of ERK1/2 proteins level born in the living construct. In conclusion, we believe that the use of the hPDLSCs and E-hPDLSCs coculture togheter with BioR as substrate, could represent an efficient model able to activate through ERK1/2 signaling pathway the osteoangiogenesis process, and then representing a new potential engineered platform for surgeons during the repair and the healing of bone defects.
In-Situ Raman Characterization of Initial Corrosion Behavior of Copper in Neutral 3.5% (wt.) NaCl Solution
Authors: Liu Ming , Li Jun
Published: July 2019

In order to investigate the role of chloride ion in the corrosion film formation of copper and its evolution over time, the initial corrosion behavior of copper in neutral 3.5% (wt.) NaCl solution was characterized by in-situ Raman spectroscopy along with electrochemical tests. The results demonstrated that the cuprous chloride complexes, such as CuCl and CuCl 2 − were produced through electrode processes, while the cuprite, Cu 2 O seemed to be formed via the chemical precipitation reaction instead of a direct electrochemical transformation from the metal matrix or CuCl and it occurred rather slowly. At the open circuit potential, the chlorides were generated first in the initial 2 h and then they transformed to the oxides with the CuCl 2 − content in the interface increasing. The in-situ Raman characterization directly evidenced the previously reported mechanism of growth of oxide layers on copper surfaces in neutral Cl − media and clearly showed the formation of a corrosion product film and its evolution over time. The electrochemical tests corresponded to the results of in-situ Raman characterization well.
Change in Electric Contact Resistance of Low-Voltage Relays Affected by Fault Current
Authors: Ksiazkiewicz Andrzej , Dombek Grzegorz , Nowak Karol
Published: July 2019

Contact resistance is an important maintenance parameter for electromagnetic switches, including low-voltage relays. The flow of significant current through electric contacts may influence the contact surface and thus the value of the electric contact resistance (ECR). The change in ECR is influenced not only by the value of current but also by the current phase. Therefore, the impact of the switching short-circuit current’s phase on the ECR was analyzed in this paper. Significant changes in the resistance after each switching cycle were observed. The ECR decreased significantly after each make operation, and a correlation with current amplitude, total let-through energy, and short-circuit time was not observed.
Characterization of Sodium and Potassium Nitrate Contaminated Polyaniline-Poly (Ethylene Oxide) Composites Synthesized via Facile Solution Casting Technique
Authors: Bilal Salma , Arif Muhammad , Khan Muhammad Saleem , Shah Anwar-ul-Haq Ali
Published: July 2019

Fabrication of composites by developing simple techniques can be an effective way to modify some properties of individual materials. The present study relates to facile synthesis of sodium nitrate (NaNO3) and potassium nitrate (KNO3) contaminated polyaniline (PANI) and poly (ethylene oxide) (PEO) composites without using any additives, plasticizers, or fibers. The physic-chemical and rheological properties of synthesized composites were analyzed. The composites showed enhancement in both storage and loss modules in comparison with the polymer matrices. The dynamic viscosity of the synthesized materials has inverse relation with that of temperature and shear stress. Rheological analysis reveals a continuous drop off in viscosity by increasing shear stress. The flow behavior was affected little by temperature. However, the overall results showed a shear thinning effect suggesting that polymer composites show non-Newtonian behavior. The addition of NaNO3 and KNO3 had a profound effect on shear viscosity of the materials, although the overall shear thinning behavior prevails. The PANI-PEO composite follows, as the first approximation models, both Bingham and modified Bingham models, while the salt contaminated system follows only the Bingham model. Both show shear stress values. The greater values of storage (G′) and loss (G″) modulus of composites than PANI-PEO blend suggests excellent elasticity, better stiffness, and good mechanical strength of the composites. Furthermore, the composites were more thermally stable than pure polymers.
An Efficient Approach for Nitrogen Diffusion and Surface Nitriding of Boron-Titanium Modified Stainless Steel Alloy for Biomedical Applications
Authors: Ali Sadaqat , Abdul Rani Ahmad Majdi , Mufti Riaz Ahmad , Hastuty Sri , Hussain Murid , Shehzad Nasir , Baig Zeeshan , Abdu Aliyu Abdul Azeez
Published: July 2019

Austenitic 316L stainless steel has been the most widely acceptable biomaterial for producing implants. The downside of this material includes the leaching of nickel ions from the matrix that limits its’ usage in implant manufacturing. In this research, production of stainless steel alloy modified with boron and titanium is investigated. The sintering of the alloy systems is carried out in nitrogen atmosphere for a dwell time of 8 h. The X-Ray diffraction (XRD) analysis reveals that dwell time and alloy composition leads to the formation of strong nitrides and borides. The X-Ray Photoelectron Spectroscopy (XPS) results show the presence of nitrogen on to the surface of sintered specimens. The nitride layer on the surface of the specimens is helpful in the retention of nickel ions in the stainless steel matrix, as indicated in the weight loss measurements. The cytotoxicity assessment indicates that the developed alloys are biocompatible and can be used as implant materials.
3D Printing of Highly Pure Copper
Authors: Tran Thang Q. , Chinnappan Amutha , Lee Jeremy Kong Yoong , Loc Nguyen Huu , Tran Long T. , Wang Gengjie , Kumar Vishnu Vijay , Jayathilaka W. A. D. M. , Ji Dongxiao , Doddamani Mrityunjay , Ramakrishna Seeram
Published: July 2019

Copper has been widely used in many applications due to its outstanding properties such as malleability, high corrosion resistance, and excellent electrical and thermal conductivities. While 3D printing can offer many advantages from layer-by-layer fabrication, the 3D printing of highly pure copper is still challenging due to the thermal issues caused by copper’s high conductivity. This paper presents a comprehensive review of recent work on 3D printing technology of highly pure copper over the past few years. The advantages and current issues of 3D printing methods are compared while different properties of copper parts printed by these methods are summarized. Finally, we provide several potential applications of the 3D printed copper parts and an overview of current developments that could lead to new improvements in this advanced manufacturing field.
Design of Ultra-Compact Optical Memristive Switches with GST as the Active Material
Authors: Wang Ningning , Zhang Hanyu , Zhou Linjie , Lu Liangjun , Chen Jianping , Rahman B.M.A.
Published: July 2019

In the following study, we propose optical memristive switches consisting of a silicon waveguide integrated with phase-change material Ge2Sb2Te5 (GST). Thanks to its high refractive index contrast between the crystalline and amorphous states, a miniature-size GST material can offer a high switching extinction ratio. We optimize the device design by using finite-difference-time-domain (FDTD) simulations. A device with a length of 4.7 μm including silicon waveguide tapers exhibits a high extinction ratio of 33.1 dB and a low insertion loss of 0.48 dB around the 1550 nm wavelength. The operation bandwidth of the device is around 60 nm.
Treatment with, Resveratrol, a SIRT1 Activator, Prevents Zearalenone-Induced Lactic Acid Metabolism Disorder in Rat Sertoli Cells
Authors: Cai Peirong , Feng Nannan , Zheng Wanglong , Zheng Hao , Zou Hui , Yuan Yan , Liu Xuezhong , Liu Zongping , Gu Jianhong , Bian Jianchun
Published: July 2019

Zearalenone (ZEA) interferes with the function of the male reproductive system, but its molecular mechanism has yet to be completely elucidated. Sertoli cells (SCs) are important in the male reproductive system. Silencing information regulator 1 (SIRT1) is a cell metabolism sensor and resveratrol (RSV) is an activator of SIRT1. In this study we investigated whether SIRT1 is involved in the regulation of ZEA-induced lactate metabolism disorder in SCs. The results showed that the cytotoxicity of ZEA toward SCs increased with increasing ZEA concentration. Moreover, ZEA induced a decrease in the production of lactic acid and pyruvate of SCs and inhibited the expression of glycolytic genes and lactic acid production-related proteins. ZEA also led to a decreased expression of SIRT1 in energy receptors and decreased ATP levels in SCs. However, the ZEA-induced cytotoxicity and decline in lactic acid production in SCs were alleviated by the use of RSV, which is an activator of SIRT1. In summary, ZEA decreased lactic acid production in SCs, while the treatment with an SIRT1 activator, RSV, restored the inhibition of lactic acid production in SCs and reduced cytotoxicity of ZEA toward SCs.
The Influence of Yeast Strain, β-Cyclodextrin, and Storage Time on Concentrations of Phytochemical Components, Sensory Attributes, and Antioxidative Activity of Novel Red Apple Ciders
Authors: Lachowicz Sabina , Oszmiański Jan , Uździcka Martyna , Chmielewska Joanna
Published: July 2019

The yeast strain and storage time is an important factor affecting the development of phytochemicals and sensory attributes in ciders. Therefore, the aim of this study was to determine the influence of yeast strains (Saccharomyces bayanus and Saccharomyces cerevisiae), β-cyclodextrin (BCD), and storage time on physicochemical parameters, contents of phenolic compounds (ultra-performance liquid chromatography with photodiode array detector coupled to quadrupole time-of-flight tandem mass spectrometry (UPLC–PDA–QToF-MS/MS)), antioxidative activity (free radical-scavenging ability (ABTS) and ferric reducing antioxidative power (FRAP) assay), and sensory attributes of new cider from the “Bella Marii” cultivar of red apple. The pH value, acidity, concentrations of alcohol, organic acids, and polyphenols; and the color and antioxidative properties were evaluated in red apple ciders immediately after fermentation and after three months of storage at 4 °C. S. cerevisiae SIHAFERM Finesse Red with BCD and SIHAFERM Finesse Red yeast strain especially contributed to obtaining ciders with a high content of the tested compounds. The use of BCD during fermentation significantly influenced the protection of bioactive compounds, by as much as 18%. Storage time had an impact on concentrations of the tested components (mainly on the total flavan-3-ols and phenolic acids). Based on the achieved values of parameters analyzed in red apple ciders and results of the consumer acceptance test, it may be concluded that red apple offers vast potential for the production of ciders with a high content of polyphenolic compounds.
Gastrointestinal Tolerance, Growth and Safety of a Partly Fermented Formula with Specific Prebiotics in Healthy Infants: A Double-Blind, Randomized, Controlled Trial
Authors: Rodriguez-Herrera Alfonso , Mulder Kelly , Bouritius Hetty , Rubio Rocio , Muñoz Antonio , Agosti Massimo , Lista Gianluca , Corvaglia Luigi , Ludwig Thomas , Abrahamse-Berkeveld Marieke , Perez-Navero Juan L.
Published: July 2019

This study evaluated the effect of a partly fermented infant formula (using the bacterial strains Bifidobacterium breve C50 and Streptococcus thermophilus 065) with a specific prebiotic mixture (short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS; 9:1)) on the incidence of gastrointestinal symptoms, stool characteristics, sleeping and crying behaviour, growth adequacy and safety. Two-hundred infants ≤28 days of age were assigned either to experimental infant formula containing 30% fermented formula and 0.8 g/100 mL scGOS/lcFOS or to non-fermented control infant formula without scGOS/lcFOS. A group of breastfed infants served as a reference. No relevant differences in parent-reported gastrointestinal symptoms were observed. Stool consistency was softer in the experimental versus control group with values closer to the breastfed reference group. Daily weight gain was equivalent for both formula groups (0.5 SD margins) with growth outcomes close to breastfed infants. No clinically relevant differences in adverse events were observed, apart from a lower investigator-reported prevalence of infantile colic in the experimental versus control group (1.1% vs. 8.7%; p < 0.02). Both study formulae are well-tolerated, support an adequate infant growth and are safe for use in healthy term infants. Compared to the control formula, the partly fermented formula with prebiotics induces stool consistencies closer to breastfed infants.
A Personalised Dietary Approach—A Way Forward to Manage Nutrient Deficiency, Effects of the Western Diet, and Food Intolerances in Inflammatory Bowel Disease
Authors: Laing Bobbi B , Lim Anecita Gigi , Ferguson Lynnette R
Published: July 2019

This review discusses the personalised dietary approach with respect to inflammatory bowel disease (IBD). It identifies gene–nutrient interactions associated with the nutritional deficiencies that people with IBD commonly experience, and the role of the Western diet in influencing these. It also discusses food intolerances and how particular genotypes can affect these. It is well established that with respect to food there is no “one size fits all” diet for those with IBD. Gene–nutrient interactions may help explain this variability in response to food that is associated with IBD. Nutrigenomic research, which examines the effects of food and its constituents on gene expression, shows that—like a number of pharmaceutical products—food can have beneficial effects or have adverse (side) effects depending on a person’s genotype. Pharmacogenetic research is identifying gene variants with adverse reactions to drugs, and this is modifying clinical practice and allowing individualised treatment. Nutrigenomic research could enable individualised treatment in persons with IBD and enable more accurate tailoring of food intake, to avoid exacerbating malnutrition and to counter some of the adverse effects of the Western diet. It may also help to establish the dietary pattern that is most protective against IBD.
Biological Obstacles for Identifying In Vitro-In Vivo Correlations of Orally Inhaled Formulations
Authors: Fröhlich Eleonore
Published: July 2019

Oral inhalation of drugs is the classic therapy of obstructive lung diseases. In contrast to the oral route, the link between in vitro and in vivo findings is less well defined and predictive models and parameters for in vitro-in vivo correlations are missing. Frequently used in vitro models and problems in obtaining in vivo values to establish such models and to identify the action of formulations in vivo are discussed. It may be concluded that major obstacles to link in vitro parameters on in vivo action include lack of treatment adherence and incorrect use of inhalers by patients, variation in inhaler performance, changes by humidity, uncertainties about lung deposition, and difficulties to measure drug levels in epithelial lining fluid and tissue. Physiologically more relevant in vitro models, improvement in inhaler performance, and better techniques for in vivo measurements may help to better understand importance and interactions between individual in vitro parameters in pulmonary delivery.
pH-Sensitive Chitosan–Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells
Authors: Pilipenko Iuliia , Korzhikov-Vlakh Viktor , Sharoyko Vladimir , Zhang Nan , Schäfer-Korting Monika , Rühl Eckart , Zoschke Christian , Tennikova Tatiana
Published: July 2019

Chitosan has been extensively studied as a genetic drug delivery platform. However, its efficiency is limited by the strength of DNA and RNA binding. Expecting a reduced binding strength of cargo with chitosan, we proposed including heparin as a competing polyanion in the polyplexes. We developed chitosan–heparin nanoparticles by a one-step process for the local delivery of oligonucleotides. The size of the polyplexes was dependent on the mass ratio of polycation to polyanion. The mechanism of oligonucleotide release was pH-dependent and associated with polyplex swelling and collapse of the polysaccharide network. Inclusion of heparin enhanced the oligonucleotide release from the chitosan-based polyplexes. Furthermore, heparin reduced the toxicity of polyplexes in the cultured cells. The cell uptake of chitosan–heparin polyplexes was equal to that of chitosan polyplexes, but heparin increased the transfection efficiency of the polyplexes two-fold. The application of chitosan–heparin small interfering RNA (siRNA) targeted to vascular endothelial growth factor (VEGF) silencing of ARPE-19 cells was 25% higher. Overall, chitosan–heparin polyplexes showed a significant improvement of gene release inside the cells, transfection, and gene silencing efficiency in vitro, suggesting that this fundamental strategy can further improve the transfection efficiency with application of non-viral vectors.
Protein Hydrolysate or Plant Extract-based Biostimulants Enhanced Yield and Quality Performances of Greenhouse Perennial Wall Rocket Grown in Different Seasons
Authors: Caruso Gianluca , De Pascale Stefania , Cozzolino Eugenio , Giordano Maria , El-Nakhel Christophe , Cuciniello Antonio , Cenvinzo Vincenzo , Colla Giuseppe , Rouphael Youssef
Published: July 2019

Research has been increasingly focusing on the environmentally friendly biostimulation of vegetable crop performances under sustainable farming management. An experiment was carried out in southern Italy on Diplotaxis tenuifolia to assess the effects of two plant biostimulants (Legume-derived protein hydrolysate, Trainer®; Tropical plant extract, Auxym®) and a non-treated control, in factorial combination with three crop cycles (autumn–winter; winter; and winter–spring) on leaf yield, photosynthetic and colour status, quality, elemental composition, antioxidant content and activity. Both biostimulants prevalently contain amino acids and soluble peptides, showing the major effects on crop performances, though Auxym also has a small percentage of phytohormones and vitamins. The biostimulants enhanced plant growth and the productivity of perennial wall rocket. The winter–spring cycle led to higher leaf yield than the winter one. The two plant biostimulants enhanced leaf dry matter, oxalic and citric acids, Ca and P concentrations, phenols and ascorbic acid content as well as antioxidant activity, but did not increase nitrate content. A presumed mechanism involved in the enhancement of crop production could be attributed to the improvement of mineral nutrient availability and uptake. The winter–spring cycle elicited higher antioxidant content and activity than winter crops. Our current study shows that both the legume-derived protein hydrolysate and tropical plant extract represent an effective tool for boosting the yield, nutritional and functional quality of vegetable produce in the view of sustainable crop systems.
Metallo-Supramolecular Hydrogels from the Copolymers of Acrylic Acid and 4-(2,2′:6′,2″-terpyridin-4′-yl)styrene
Authors: Zhang Huiqin , Liu Pan , Chi Zheng , Chen Xuegang
Published: July 2019

Hydrophilic copolymers containing 2,2′:6′,2″-terpyridine moieties and acrylic acid (AA) units poly (acrylic acid-co-4-(2,2′:6′,2″-terpyridin-4′-yl)styrene) (P(AA-co-TPY)) were synthesized and characterized. Coordinated with different transition metal ions, the dilute aqueous solution of the copolymers exhibited red-shifted UV-vis absorption peaks of π-π* transition from 317 to 340 nm. Further, interacting with iron ions, the copolymer showed new absorption peaks at a longer wavelength region (570 nm) and the absorption intensity enhanced with increase of the ion concentration. When enough ions were added to coordinate with the 2,2′:6′,2″-terpyridine moieties, novel metallo-supramolecular hydrogels were obtained due to the formation of metal coordination bonds between polymer back bones and transition metal ions (Ni2+, Zn2+, Cd2+, Fe2+ and Cu2+), which acted as self-assembly crosslinking structures. The mechanical strength and morphology of the resulting metallo-supramolecular hydrogels have been investigated.
Invisible Dress: Weaving a Theology of Fashion
Authors: Ambrosio Alberto Fabio
Published: July 2019

This article establishes the framework for a (Christian) theology of fashion, the development of which comes under a research project set up between Luxembourg (Luxembourg School of Religion & Society) and Paris (Collège des Bernardins). The text is structured around three areas: the first reveals how theology can accommodate in its field of thought both the idea of dress (also viewed in terms of its materiality) and the way in which modern society experiments with it: fashion. For as much as theological discourse, particularly Christian, might have shown itself to be critical regarding modern day fashion, it has nevertheless failed to come up with any real theological reflection on the subject. The second area aims to explore responsible ethics for fashion. Often moralising, the attitude of Christian theology needs to give way to an ethical and—vitally—ecological analysis of the effects of fashion in today’s world. Clothing might still cover people’s bodies, but the issue is not restricted to an individual moral point of view, and extends to the social rules of an ethic that is also one of environmental responsibility. Finally, the totally new perspective that I adopt for outlining these areas requires the aesthetics of dress and fashion to be addressed from a theological point of view. For all its rich history, theological aesthetics has hardly ever concerned itself with developing an aesthetic discourse for dress and fashion, other than for liturgical and religious attire. Once these three new research perspectives have been discussed, I want to outline another field of study, in itself extremely fertile: a treasure trove of metaphors and analogies that would be very useful in theological thinking, adding to its inventory terms originating in the uncovering and stripping away of old ways of thinking that no longer convey in contemporary language the mystery that it is meant to clothe.
High-Resolution Lightning Detection and Possible Relationship with Rainfall Events over the Central Mediterranean Area
Authors: Paliaga Guido , Donadio Carlo , Bernardi Marina , Faccini Francesco
Published: July 2019

Lightning activity is usually associated with precipitations events and represents a possible indicator of climate change, even contributing to its increase with the production of NOx gases. The study of lightning activity on long temporal periods is crucial for fields related to atmospheric phenomena from intense rain-related hazard processes to long-term climate changes. This study focuses on 19 years of lightning-activity data, recorded from Italian Lightning Detection Network SIRF, part of the European network EUCLID (European Cooperation for Lightning Detection). Preliminary analysis was dedicated to the spatial and temporal assessment of lightning through detection in the Central Mediterranean area, focusing on yearly and monthly data. Temporal and spatial features have been analyzed, measuring clustering through the application of global Moran’s I statistics and spatial local autocorrelation; a Mann–Kendall trend test was performed on monthly series aggregating the original data on a 5 × 5 km cell. A local statistically significant trend emerged from the analysis, suggesting possible linkage between surface warming and lightning activity.
A Priori Solar Radiation Pressure Model for BeiDou-3 MEO Satellites
Authors: Yan Xingyuan , Liu Chenchen , Huang Guanwen , Zhang Qin , Wang Le , Qin Zhiwei , Xie Shichao
Published: July 2019

Due to the cuboid satellite body of BeiDou-3 satellites, the accuracy of their orbit showed a trend of systematic variation with the sun-satellite-earth angle (ε) using the Extend CODE Orbit Model (ECOM1). Therefore, an a priori cuboid box-wing model (named the cuboid model) is necessary to compensate ECOM1. Considering that the body-dimensions and optical properties of the BeiDou-3 satellites used to construct the box-wing model have not yet been fully released, the adjustable box-wing model (ABW) was used for precise orbit determination (POD). The a priori cuboid box-wing model was directly estimated by the precision radiation accelerations, obtained from ABW POD. When using ECOM1 model, for 14 < β < 40°, a linear systematic variation of D0 related to the elevation of the sun above the orbital plane (β-angle) with a slope of 0.048 nm/s2/°, was found for C30. After adding the cuboid model to assist ECOM1 (named Cuboid + ECOM1), the slope was reduced to 0.005 nm/s2/°, and for C20 satellite, the standard deviation (STD) of D0 was improved, from 1.28 to 0.85 nm/s2 (34%). For satellite laser ranging (SLR) validation, when using the ECOM1 model, the systematic variation with the ε angle was about 14 cm for C20 and C30. After using the Cuboid + ECOM1 model, the variation was significantly reduced to about 5 cm. For C20 and C21, compared with the ECOM1 model, the root mean square (RMS) of the ECOM2 and Cuboid + ECOM1 model was improved by about 0.54 (10.3%) and 0.43 cm (8.7%). For C29 and C30, the RMS of ECOM2 and Cuboid + ECOM1 model was improved for about 0.7 (10.9%) and 1.6 cm (25.6%). Finally, the RMS of the SLR residuals of 4.37 to 4.88 cm was achieved for BeiDou-3 POD.
Embracing Sustainability in Shipping: Assessing Industry’s Adaptations Incited by the, Newly, Introduced ‘triple bottom line’ Approach to Sustainable Maritime Development
Authors: Fasoulis Ioannis , Kurt Rafet Emek
Published: July 2019

Increasing environmental, social and economic problems, born by unceasing economic growth, have transformed our approach to the development concept. The 1980s saw the appearance of the sustainable development term and, during the 1990s, sustainability notion was implicitly framed as an integrated concept, frequently, termed as the ‘triple bottom line’ approach. Among several initiatives and efforts to balance our economic and societal pursuits with environmental challenges the, lately, introduced United Nations (UN) Sustainable Development Goals (SDGs) refer to a remarkable evolution, which came to strengthen and establish sustainability conception as an integrated social, economic and environmental triptych. International shipping, as the major carrier of world trade and significant contributor to environmental degradation has, definitely, a vital role to play in facilitating the UN’s sustainability venture. Although there is a great amount of legislative instruments, codes and guidance to address sustainability in shipping, though, limited research has been devoted to identify how the tanker and dry bulk maritime sector has responded to such recent cohesive attitude to sustainable maritime development. Through a quantitative research approach this empirical study aimed to investigate maritime industry’s insights and attitudes in relation to the, newly, introduced triple bottom line approach to global sustainable development. Research data were collected via a questionnaire survey conducted to 50 tanker and/or dry bulk shipping companies. Pearson’s chi-square test of independence and Spearman’s correlation coefficient measures were utilized to test our three formulated hypotheses. Findings highlighted increasing awareness and adaptation of the maritime sector to the triple bottom line approach and, subsequent, sustainability absorption under the auspices of a corporate social responsibility (CSR) business model. Introduction of sustainable development in an integrated manner appears to have influenced the extent that statutory maritime regulations occupy to the formulation of marine safety management systems. To sum up, the integrated management system model turned out to be the most rated tactic to manage sustainability and, as such, a conceptual CSR framework was proposed to facilitate such an objective.
The Asylum Seekers in Non-Metropolitan Areas in France: Between Temporary Integration and Leading to Autonomy. The Case of the Ambertois Territory
Authors: Arfaoui Rafik
Published: July 2019

This article focuses on the integration process of people seeking asylum in non-metropolitan areas in France. It conceptualizes the reception of asylum seekers involving two interrelated approaches: the utilitarian approach and the humanitarian approach. This article is based on surveys, participatory and sensitive cartography, and participant observation conducted in the Ambertois territory between 2017 and 2018. I find the Ambertois territory can be considered a “fragile space,” particularly in terms of demographics, with difficulties in maintaining public services. These difficulties are risks for asylum seekers, and are impacting the urban space. These risks are intensified by the national and regional level policies like the recent reform of the asylum and immigration act on the one hand, and the suffering they experienced throughout their migratory journey on the other. Faced with these risks, local synergies, which facilitate the integration of asylum seekers, are emerging from local actors. This integration is temporary and is considered by local actors as leading to the autonomy of asylum seekers.
Exploring Service Quality among Online Sharing Economy Platforms from an Online Media Perspective
Authors: Cristobal-Fransi Eduard , Hernández-Soriano Francisco , Ferrer-Rosell Berta , Daries Natalia
Published: July 2019

The sharing economy has become a new socioeconomic activity that allows the co-creation, production, distribution and consumption of goods and services between individuals, driven by Web 2.0 and e-word of mouth. How these online platforms communicate their content is critical. This paper seeks to develop a scale for measuring the perceived quality of websites that offer information about sharing economy services focused on online peer-to-peer accommodation. The resulting model is validated by means of structural equations and is composed of four dimensions (efficiency; reliability, privacy/security; and communication). The influence that perceived quality exerts on satisfaction and loyalty is then explored from an online media perspective. A scale resulting from the combination of these two areas of knowledge (online media and e-service quality) may take advantage of the more beneficial features they have to offer and provide us with as balanced and convergent a model as possible. The results of the study show that all of the initial hypotheses are confirmed except one. Efficiency, reliability and privacy/security positively influence the perceived quality of a collaborative accommodation portal, whereas communication does not.
The Search for the Meaning of Soil Health: Lessons from Human Health and Ecosystem Health
Authors: Ng Ee Ling , Zhang Junling
Published: July 2019

Soil is central to human wellbeing through its provision of critical ecosystem services, including food and clean water. These services emerge through the self-organising nature of the soil system. Here, we consider the lessons learnt from the evolution of the understanding of human and ecosystem health for the conceptualisation and application of soil health. We share the fundamental and practical challenges of managing the land with respect to soil health, and the need for policy to drive the protection of soil as one of our most important non-renewable natural resources.
The Effect of Corporate Visibility on Corporate Social Responsibility
Authors: Li Frank , Morris Taylor , Young Brian
Published: July 2019

Outside of direct ownership, the general public may feel it is an implicit stakeholder of a firm. As the public becomes more vested in a firm’s actions, the firm may be more likely to engage in Corporate Social Responsibility (CSR) activities. We proxy for the public’s stake in a firm with public visibility. Based on 3400 unique newspaper publications from 1994–2008, we measure visibility for the S&P 500 firms with the frequency of print articles per year concerning the firm. We find that visibility has a signficant, positive relationship with the CSR rating. Evidence also suggests this relationship may be causal and working in one direction, from visibility to CSR. While the existing literature provides other factors that influence CSR, visibility proves to have the most significant impact when tested alongside those other factors. Visibility also has a mediating effect on the relationship between CSR rating and firm size. CSR rating and firm size relate negatively for the lowest visibility firms and positively for the highest. This paper provides strong evidence that visibility is an important factor to consider for studies on corporate social performance.
Isolation of an Equine Foamy Virus and Sero-Epidemiology of the Viral Infection in Horses in Japan
Authors: Kirisawa Rikio , Toishi Yuko , Hashimoto Hiromitsu , Tsunoda Nobuo
Published: July 2019

An equine foamy virus (EFV) was isolated for the first time in Japan from peripheral blood mononuclear cells of a broodmare that showed wobbler syndrome after surgery for intestinal volvulus and the isolate was designated as EFVeca_LM. Complete nucleotide sequences of EFVeca_LM were determined. Nucleotide sequence analysis of the long terminal repeat (LTR) region, gag, pol, env, tas, and bel2 genes revealed that EFVeca_LM and the EFV reference strain had 97.2% to 99.1% identities. For a sero-epidemiological survey, indirect immunofluorescent antibody tests were carried out using EFVeca_LM-infected cells as an antigen against 166 sera of horses in five farms collected in 2001 to 2002 and 293 sera of horses in eight farms collected in 2014 to 2016 in Hokkaido, Japan. All of the farms had EFV antibody-positive horses, and average positive rates were 24.6% in sera obtained in 2001 to 2002 and 25.6% in sera obtained in 2014 to 2016 from broodmare farms. The positive rate in a stallion farm (Farm A) in 2002 was 10.7%, and the positive rates in two stallion farms, Farms A and B, in 2015 were 40.9% and 13.3%, respectively. The results suggested that EFV infection is maintained widely in horses in Japan.
Nine Novel Phages from a Plateau Lake in Southwest China: Insights into Aeromonas Phage Diversity
Authors: Bai Meng , Cheng Ya-Hui , Sun Xue-Qin , Wang Zi-Yi , Wang Yong-Xia , Cui Xiao-Long , Xiao Wei
Published: July 2019

Aeromonas species are common pathogens of fish and some of them can opportunistically cause infectious diseases in humans. The overuse of antibiotics has led to the emergence of bacterial drug-resistance. To date, only 51 complete genome sequences of Aeromonas phages are available in GenBank. Here, we report the isolation of nine Aeromonas phages from a plateau lake in China. The protein cluster, dot plot and ANI analyses were performed on all 60 currently sequenced Aeromonas phage genomes and classified into nine clusters and thirteen singletons. Among the nine isolated phages, the DNA-packaging strategy of cluster 2L372D (including 2L372D, 2L372X, 4L372D, 4L372XY) is unknown, while the other five phages use the headful (P22/Sf6) DNA-packaging strategy. Notably, the isolated phages with larger genomes conservatively encode auxiliary metabolism genes, DNA replication and metabolism genes, while in smaller phage genomes, recombination-related genes were conserved. Finally, we propose a new classification scheme for Aeromonas phages.
River Model Calibration Based on Design of Experiments Theory. A Case Study: Meta River, Colombia
Authors: Acuña Guillermo J. , Ávila Humberto , Canales Fausto A.
Published: July 2019

Numerical models are important tools for analyzing and solving water resources problems; however, a model’s reliability heavily depends on its calibration. This paper presents a method based on Design of Experiments theory for calibrating numerical models of rivers by considering the interaction between different calibration parameters, identifying the most sensitive parameters and finding a value or a range of values for which the calibration parameters produces an adequate performance of the model in terms of accuracy. The method consists of a systematic process for assessing the qualitative and quantitative performance of a hydromorphological numeric model. A 75 km reach of the Meta River, in Colombia, was used as case study for validating the method. The modeling was conducted by using the software package MIKE-21C, a two-dimensional flow model. The calibration is assessed by means of an Overall Weighted Indicator, based on the coefficient of determination of the calibration parameters and within a range from 0 to 1. For the case study, the most significant calibration parameters were the sediment transport equation, the riverbed load factor and the suspended load factor. The optimal calibration produced an Overall Weighted Indicator equal to 0.857. The method can be applied to any type of morphological models.
Simulation and Analysis of the Water Balance of the Nam Co Lake Using SWAT Model
Authors: Adnan Muhammad , Kang Shichang , Zhang Guoshuai , Saifullah Muhammad , Anjum Muhammad Naveed , Ali Ayaz Fateh
Published: July 2019

Rapid change of alpine lakes in the Tibetan Plateau (TP) is a clear manifestation of regional-scale climate variability that can be investigated by quantifying the regional hydrological cycle. The degree-day model (DDM) coupled with the Soil and Water Assessment Tool (SWAT) model were used to quantify the water budget of the Nam Co Lake over the period of 2007 to 2013. Driven by local observed meteorological data, the coupled model was successfully validated with the observed lake levels (with R2 = 0.65, NSE = 0.61, and PBIAS = −2.26). Analysis of the water balance revealed that rapid enlargement of the Nam Co Lake was primarily associated with precipitation increase while glacier melt played its role as the potential secondary driver in lake expansion. However, temporal analysis of lake expansion displayed that supremacy of precipitation and glacier melt interchanged between the years. It was found that average annual relative contributions of the precipitation, including direct precipitation on the lake, and glacier melt to the lake were 57% (or 667 mm), and 43% (or 502 mm), respectively. Besides, it was observed that annual values of actual evapotranspiration (ET) from the lake, glaciated, and non-glaciated subbasins were 615 mm, 280 mm, and 234 mm respectively. The average annual glacier mass balance (GMB) of the Nam Co basin was −150.9 millimeter water equivalent (mm w.e.). The relatively high amount of glacier melt was a consequence of the substantial increase in annual temperature in the lake basin. This work is of importance for understanding the rapid water cycle in the TP under global warming. Moreover, this work will also be helpful in monitoring and sustaining the local ecosystem and infrastructure, which is under risk due to rapid lake expansion as a result of climate change in the TP.
Numerical Simulation and Experiment Study on the Characteristics of Non-Darcian Flow and Rheological Consolidation of Saturated Clay
Authors: Liu Zhongyu , Xia Yangyang , Shi Mingsheng , Zhang Jiachao , Zhu Xinmu
Published: July 2019

To investigate the characteristics of the non-Darcian water flow through saturated clay and one-dimensional rheological consolidation behaviors of the soil in the Henan Province, we conducted constant-head permeability and one-dimensional rheological consolidation tests with one-way drainage using improved permeameter and oedometer tests, respectively. We then used Hansbo’s flow equation to classify the permeability test results and one-dimensional rheological consolidation equation combined with unified hardening (UH) constitutive model considering time effect was introduced to simulate the oedometer test results. The obtained results showed that the improved constant-head permeability test device was suitable for saturated clays, and that the UH constitutive model and Hansbo’s flow equation had good applications for the saturated clays investigated in this experiment.
Ecotoxicological Analysis of Emerging Contaminants from Wastewater Discharges in the Coastal Zone of Cihuatlán (Jalisco, Mexico)
Authors: Arguello-Pérez Miguel Ángel , Mendoza-Pérez Jorge Alberto , Tintos-Gómez Adrián , Ramírez-Ayala Eduardo , Godínez-Domínguez Enrique , Silva-Bátiz Francisco de Asís
Published: July 2019

This research provides a baseline tool to detect, predict and scientifically evaluate the toxic environmental impact generated by chemical substances that are categorized as emerging contaminants (ECs) with endocrine disruptive action. The present study was carried out in five effluents of wastewater produced by urban and rural settlements of the coastal zone of Cihuatlan, Jalisco. Five compounds, considered ECs and that act as endocrine disruptors, were analyzed: Diclofenac, Ibuprofen, Ketorolac, Pentachlorophenol (PCP), and Estradiol. The toxicity level (TEQ) of the ECs is estimated by a Quantitative Structure-Activity Relationship (QSAR) analysis, evaluating their concentration and assessing the risk involved in the incorporation of each one into the environment. The presence of the ECs was confirmed in all the studied sites. It was attested that the concentrations of pollutants Diclofenac, Ibuprofen, Ketorolac, and Pentachlorophenol were within the toxic range, whereas the compound Estradiol was found in concentrations that represent a high toxicity in the same effluents. This research recognizes that the analysis of the physicochemical properties of substances allows for predicting whether a contaminant is likely to act and persist in the environment and, in turn, bioaccumulate in organisms.
Application of Long Short-Term Memory (LSTM) Neural Network for Flood Forecasting
Authors: Le Xuan-Hien , Ho Hung Viet , Lee Giha , Jung Sungho
Published: July 2019

Flood forecasting is an essential requirement in integrated water resource management. This paper suggests a Long Short-Term Memory (LSTM) neural network model for flood forecasting, where the daily discharge and rainfall were used as input data. Moreover, characteristics of the data sets which may influence the model performance were also of interest. As a result, the Da River basin in Vietnam was chosen and two different combinations of input data sets from before 1985 (when the Hoa Binh dam was built) were used for one-day, two-day, and three-day flowrate forecasting ahead at Hoa Binh Station. The predictive ability of the model is quite impressive: The Nash–Sutcliffe efficiency (NSE) reached 99%, 95%, and 87% corresponding to three forecasting cases, respectively. The findings of this study suggest a viable option for flood forecasting on the Da River in Vietnam, where the river basin stretches between many countries and downstream flows (Vietnam) may fluctuate suddenly due to flood discharge from upstream hydroelectric reservoirs.