bluuebunny/crossref_metadata_2025 huggingface dataset:
ОБУЧЕНИЕ ВЕРЕ И ГРАМОТЕ – ИНСТРУМЕНТ СОХРАНЕНИЯ И ВОЗОБНОВЛЕНИЯ ТРАДИЦИИ
Authors: Поздеева Ирина Васильевна
Published: June 2023

В статье анализируется традиционное обучение, соединяющее знание грамоты с воспитанием в вере. Также показана деятельность Московского печатного двора XVII в. по изданию книг для обучения.

This paper analyses traditional education combining literacy and upbringing in the faith. The paper also highlights Moscow Printing House textbook publishing activities.
ПИСЬМА К ПРОТОИЕРЕЮ МИХАИЛУ ТРУХАНОВУ. ЧАСТЬ 2: ПИСЬМА СВЯЩЕННИКА ГЕОРГИЯ ИВАНОВИЧА РАДЕЦКОГО
Authors: Шляхтина Наталья Валерьевна
Published: June 2023

Мы продолжаем публикацию архива протоиерея Михаила Васильевича Труханова, начатую в предыдущем номере. Речь идет о письмах от людей, с которыми о. Михаил находился в лагере, а после освобождения продолжил поддерживать связь, вел переписку, встречался. В данном номере представлены письма от о. Георгия Радецкого – известного священника и исповедника советского времени, сотрудника Псковской Духовной Миссии в годы Великой Отечественной войны, приговоренного к 15 годам лагерей, но сохранившего и реализовавшего, несмотря на многие препятствия, горячее желание служить Русской Православной Церкви.

We continue the publication of the archive of Archpriest Mikhail Vasilyevich Trukhanov, begun in the previous issue. These are letters from people with whom Fr. Mikhail was in the camp, and after his release he continued to keep in touch, corresponded, met. This issue contains letters from Fr. Georgy Radetsky, a well-known priest and confessor of the Soviet era, an employee of the Pskov Spiritual Mission during the Great Patriotic War, sentenced to 15 years in the camps, but who, despite many obstacles, retained and realized his ardent desire to serve the Russian Orthodox Church.
РЕЦЕНЗИЯ НА МОНОГРАФИЮ: РАДИОНОВ А. П. ИМЯСЛАВИЕ НА ЮГЕ РОССИИ. Б/м: ИЗДАТЕЛЬСКИЕ РЕШЕНИЯ, 2022. – 362 с.
Authors: Кириченко Олег Викторович
Published: June 2023

В рецензии анализируется вышедшая в 2022 г. книга А. П. Радионова «Имяславие на юге России». Особенность данного научного труда в его обращенности к истории имяславия, главным образом, советского периода. Автора интересует не столько богословская сторона имяславских идей, достаточно изученная, сколько практическая жизнь имяславцев в годы их «жизни в миру», после изгнания с Афона. Автор показывает, что имяславцы в советский период долгое время существовали в виде монашеских общин в женских монастырях юга России. В советские годы главным для них становится вопрос исповедания. Их радикализм приобретает еще более острый характер: они живут эсхатологией, не принимают советскую власть, становятся частью катакомбной церкви. Однако их изоляционизм, нетерпимость к «имяборцам», то есть всем другим, делает их достаточно узкой, маргинальной группой даже среди оппонентов власти и официальной церкви. Неизвестная история имяславия раскрывается автором в судьбах отдельных лиц, в событиях, в региональной специфике юга России, ставшего основным местом расселения имяславцев.

The review analyzes the book «Imyaslavie in the South of Russia» by the Krasnodar author A. P. Radionov, published in 2022. The peculiarity of this scientific work is its focus on the history of name worship, mainly of the Soviet period. The author is interested not so much in the theological side of the imyaslav ideas, which has been sufficiently studied, but in the practical life of the imyaslavists during the years of their «life in the world», after being expelled from Athos. The author shows that in the Soviet period, the Imyaslavists existed for a long time in the form of monastic communities in women’s monasteries in southern Russia. In the Soviet years, the main thing for them was the question of professing. Their radicalism takes on an even sharper character: they live by eschatology, do not accept Soviet power, and become part of the catacomb church. However, their isolationism, intolerance towards «name-fighters», that is, everyone else, makes them a rather narrow, marginal group even among opponents of the authorities and the official church. The unknown history of imyaslavie is revealed by the author in the fates of individuals, in events, in the regional specifics of the south of Russia, which has become the main place of settlement of imyaslavists.
Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of Ldlr−/− mice
Authors: Keeter W. Coles , Moriarty Alina K. , Akers Rachel , Ma Shelby , Mussbacher Marion , Nadler Jerry L. , Galkina Elena V.
Published: June 2023

Background and aims

Neutrophils drive atheroprogression and directly contribute to plaque instability. We recently identified signal transducer and activator of transcription 4 (STAT4) as a critical component for bacterial host defense in neutrophils. The STAT4-dependent functions of neutrophils in atherogenesis are unknown. Therefore, we investigated a contributory role of STAT4 in neutrophils during advanced atherosclerosis.

Methods

We generated myeloid-specific Stat4ΔLysMLdlr−/−, neutrophil-specific Stat4ΔS100A8Ldlr−/−, and control Stat4fl/flLdlr−/− mice. All groups were fed a high-fat/cholesterol diet (HFD-C) for 28 weeks to establish advanced atherosclerosis. Aortic root plaque burden and stability were assessed histologically by Movat pentachrome staining. Nanostring gene expression analysis was performed on isolated blood neutrophils. Flow cytometry was utilized to analyze hematopoiesis and blood neutrophil activation. In vivo homing of neutrophils to atherosclerotic plaques was performed by adoptively transferring prelabeled Stat4ΔLysMLdlr−/− and Stat4fl/flLdlr−/− bone marrow cells into aged atherosclerotic Apoe−/− mice and detected by flow cytometry.

Results

STAT4 deficiency in both myeloid-specific and neutrophil-specific mice provided similar reductions in aortic root plaque burden and improvements in plaque stability via reduction in necrotic core size, improved fibrous cap area, and increased vascular smooth muscle cell content within the fibrous cap. Myeloid-specific STAT4 deficiency resulted in decreased circulating neutrophils via reduced production of granulocyte-monocyte progenitors in the bone marrow. Neutrophil activation was dampened in HFD-C fed Stat4ΔLysMLdlr−/− mice via reduced mitochondrial superoxide production, attenuated surface expression of degranulation marker CD63, and reduced frequency of neutrophil-platelet aggregates. Myeloid-specific STAT4 deficiency diminished expression of chemokine receptors CCR1 and CCR2 and impaired in vivo neutrophil trafficking to atherosclerotic aorta.

Conclusions

Our work indicates a pro-atherogenic role for STAT4-dependent neutrophil activation and how it contributes to multiple factors of plaque instability during advanced atherosclerosis in mice.
The deformation mechanism in the western Qiangtang terrane and its surroundings: evidence from magnetotelluric data
Authors: Gu Jiangfan , Jin Sheng , Dong Hao , Wei Wenbo , Ye Gaofeng , Zhang Letian
Published: June 2023

Located in the central part of the Tibetan Plateau, the Qiangtang terrane preserves important record of the uplift and deformation history of the Plateau, and therefore remains an attractive area of research. However, deep geophysical investigations of its western part are still limited. To further understand the deep structure of the western Qiangtang terrane and its surroundings, we use magnetotelluric array data to generate a 3D electrical structure. It reveals high resistivity anomalies in the upper crust and scattered high conductivity anomalies in the mid-lower crust. The electrical structure also suggests that the Longmu Co-Gozha Co fault once believed to be a major regional deformation boundary, may not have cut through the crust. The melt content and rheological parameters derived from the electrical structures show dominant ductile-type deformation in most of the study area, which contributes to block extrusion along the slip faults. Viscous deformation regions formed by mantle melt upwelling in the mid-lower crust may contribute to the formation of the N-S directed normal faults on the surface.
The diagnostic significance of the ZNF gene family in pancreatic cancer: a bioinformatics and experimental study
Authors: Zhu Lei , Tu Dong , Li Ruixue , Li Lin , Zhang Wenjie , Jin Wenxiang , Li Tiehan , Zhu Hong
Published: June 2023

Background: Pancreatic adenocarcinoma (PAAD) is among the most devastating of all cancers with a poor survival rate. Therefore, we established a zinc finger (ZNF) protein-based prognostic prediction model for PAAD patients.

Methods: The RNA–seq data for PAAD were downloaded from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. Differentially expressed ZNF protein genes (DE-ZNFs) in PAAD and normal control tissues were screened using the “lemma” package in R. An optimal risk model and an independent prognostic value were established by univariate and multivariate Cox regression analyses. Survival analyses were performed to assess the prognostic ability of the model.

Results: We constructed a ZNF family genes-related risk score model that is based on the 10 DE-ZNFs (ZNF185, PRKCI, RTP4, SERTAD2, DEF8, ZMAT1, SP110, U2AF1L4, CXXC1, and RMND5B). The risk score was found to be a significant independent prognostic factor for PAAD patients. Seven significantly differentially expressed immune cells were identified between the high- and low-risk patients. Then, based on the prognostic genes, we constructed a ceRNA regulatory network that includes 5 prognostic genes, 7 miRNAs and 35 lncRNAs. Expression analysis showed ZNF185, PRKCI and RTP4 were significantly upregulated, while ZMAT1 and CXXC1 were significantly downregulated in the PAAD samples in all TCGA - PAAD, GSE28735 and GSE15471 datasets. Moreover, the upregulation of RTP4, SERTAD2, and SP110 were verified by the cell experiments.

Conclusion: We established and validated a novel, Zinc finger protein family - related prognostic risk model for patients with PAAD, that has the potential to inform patient management.
Re-introduction of a bioactive bacterial endophyte back to its seaweed (Ulva sp.) host, influences the host’s microbiome
Authors: Deutsch Ynon , Ofek-Lalzar Maya , Borenstein Menahem , Berman-Frank Ilana , Ezra David
Published: June 2023

Ulva is a commercially important marine macroalga. It hosts both epiphytes and endophytes. The latter are assumed to protect Ulva through secondary metabolites. Previously, we demonstrated bioactive endophytes from macroalgae with great potential to control diseases of aquaculture. In this study, we introduced a bioactive bacterial endophyte back into its original host (Ulva sp.) and demonstrated its survival over time in fresh and freeze-dried Ulva sp. We visualized the endophyte’s location and survival in the seaweed using a Green Fluorescent Protein (GFP) reporter gene. The isolate colonized the intercellular space and survived for at least 5 months in fresh, and 12 months in freeze-dried algae, while maintaining its bioactivity against the aquaculture pathogen Streptococcus iniae. We studied the influence of the endophyte on the bacterial community in the Ulva sp. We found that once introduced, the endophyte significantly changed algal microbiota diversity and abundance. Two of Ulva’s associated bacterial species were quantified over time, suggesting different trends in absolute abundance of these bacteria between treatments. To the best of our knowledge, this is the first report of the successful introduction of an endophytic microorganism into macroalgal tissue. These findings may be useful in applied research for the potential management of aquaculture diseases.
Influence of the El Niño-Southern Oscillation on upper-ocean salinity changes in the southeast Indian ocean
Authors: Nie Xunwei , Liu Hao , Xu Tengfei , Wei Zexun
Published: June 2023

The interannual-decadal variability in the upper-ocean salinity of the southeast Indian Ocean (SEIO) was found to be highly correlated with the El Niño-Southern Oscillation (ENSO). Based on multisource data, this study revealed that this ENSO-like salinity variability mainly resides in the domain between 13°S-30°S and 100°E-120°E, and at depths above 150 m. This variability is principally driven by meridional geostrophic velocity (MGV), which changes with the zonal pattern of the sea surface height (SSH). Previous studies have reported that the variability in the SSH in the south Indian Ocean is principally driven by local-wind forcing and eastern-boundary forcing. Here the eastern-boundary forcing denotes the influence of SSH anomaly radiated from the western coast of Australia. A recent study emphasized the contribution of local-wind forcing in salinity variability in the SEIO, for its significant role in generation of the zonal dipole pattern of SSH anomaly in the south Indian Ocean, which was considered to be responsible for the anomalous MGV in the SEIO. While our results revealed a latitudinal difference between the domain where the SSH dipole pattern exists (north of 20°S) and the region in which the ENSO-like salinity variability is strongest (20°S-30°S), suggesting that this salinity variability cannot be attributed entirely to the SSH dipole pattern. Our further investigation shows that, the MGV in the SEIO changes with local zonal SSH gradient that principally driven by eastern-boundary forcing. In combination with the strong meridional salinity gradient, the boundary-driven MGV anomalies cause significant meridional salinity advection and eventually give rise to the observed ENSO-like salinity variability. This study revealed the leading role of eastern-boundary forcing in interannual variability of the upper-ocean salinity in the SEIO.
The interannual variability of the Indian Ocean subtropical mode water based on the Argo data
Authors: Adiwira Hanani , Suga Toshio
Published: June 2023

Gaining insight into the interannual variability of the Indian Ocean Subtropical Mode Water (IOSTMW) is essential for understanding ocean dynamics in the Southwest Indian Ocean, since it carries the signal of winter mixing and transports it into the ocean interior. As the number of Argo profiles in the Southwest Indian Ocean increases, it has become possible to study temporal variations in IOSTMW using observation data. We used Argo products to examine the interannual variability of the IOSTMW from 2005 to 2020. We examined various definitions to determine the most suitable definition for IOSTMW in this study, choosing to define the IOSTMW as a layer with a vertical temperature gradient of less than 1°C per 100 meters (dT/dz< 1°C/100 m) and a temperature range of 16°C–18°C because this correlates strongly with winter heat loss in the same year. This method is particularly useful for investigating how mode water captures anomalous winter mixing signals and advects them to the ocean interior via subduction. Furthermore, we found that summer stratification can play a role in either facilitating or hindering the formation of thick IOSTMW layers. Our study indicates that thin IOSTMW layers are primarily caused by extremely weak winter heat loss associated with anomalously weak latent heat, whereas thick IOSTMW formation is aided by weak summer stratification.
Identification and prediction of m7G-related Alzheimer’s disease subtypes: insights from immune infiltration and machine learning models
Authors: Ma Chao , Li Jian , Chi Yuhua , Sun Xuan , Yang Maoquan , Sui Xueqin
Published: June 2023

Introduction

Alzheimer’s disease (AD) is a complex and progressive neurodegenerative disorder that primarily affects older individuals. N7-methylguanosine (m7G) is a common RNA chemical modification that impacts the development of numerous diseases. Thus, our work investigated m7G-related AD subtypes and established a predictive model.

Methods

The datasets for AD patients, including GSE33000 and GSE44770, were obtained from the Gene Expression Omnibus (GEO) database, which were derived from the prefrontal cortex of the brain. We performed differential analysis of m7G regulators and examined the immune signatures differences between AD and matched-normal samples. Consensus clustering was employed to identify AD subtypes based on m7G-related differentially expressed genes (DEGs), and immune signatures were explored among different clusters. Furthermore, we developed four machine learning models based on the expression profiles of m7G-related DEGs and identified five important genes from the optimal model. We evaluated the predictive power of the 5-gene-based model using an external AD dataset (GSE44770).

Results

A total of 15 genes related to m7G were found to be dysregulated in patients with AD compared to non-AD patients. This finding suggests that there are differences in immune characteristics between these two groups. Based on the differentially expressed m7G regulators, we categorized AD patients into two clusters and calculated the ESTIMATE score for each cluster. Cluster 2 exhibited a higher ImmuneScore than Cluster 1. We performed the receiver operating characteristic (ROC) analysis to compare the performance of four models, and we found that the Random Forest (RF) model had the highest AUC value of 1.000. Furthermore, we tested the predictive efficacy of a 5-gene-based RF model on an external AD dataset and obtained an AUC value of 0.968. The nomogram, calibration curve, and decision curve analysis (DCA) confirmed the accuracy of our model in predicting AD subtypes.

Conclusion

The present study systematically examines the biological significance of m7G methylation modification in AD and investigates its association with immune infiltration characteristics. Furthermore, the study develops potential predictive models to assess the risk of m7G subtypes and the pathological outcomes of patients with AD, which can facilitate risk classification and clinical management of AD patients.
Association of brain tissue cerebrospinal fluid fraction with age in healthy cognitively normal adults
Authors: Zhou Liangdong , Li Yi , Sweeney Elizabeth M. , Wang Xiuyuan H. , Kuceyeski Amy , Chiang Gloria C. , Ivanidze Jana , Wang Yi , Gauthier Susan A. , de Leon Mony J. , Nguyen Thanh D.
Published: June 2023

Background and purpose

Our objective was to apply multi-compartment T2 relaxometry in cognitively normal individuals aged 20–80 years to study the effect of aging on the parenchymal CSF fraction (CSFF), a potential measure of the subvoxel CSF space.

Materials and methods

A total of 60 volunteers (age range, 22–80 years) were enrolled. Voxel-wise maps of short-T2 myelin water fraction (MWF), intermediate-T2 intra/extra-cellular water fraction (IEWF), and long-T2 CSFF were obtained using fast acquisition with spiral trajectory and adiabatic T2prep (FAST-T2) sequence and three-pool non-linear least squares fitting. Multiple linear regression analyses were performed to study the association between age and regional MWF, IEWF, and CSFF measurements, adjusting for sex and region of interest (ROI) volume. ROIs include the cerebral white matter (WM), cerebral cortex, and subcortical deep gray matter (GM). In each model, a quadratic term for age was tested using an ANOVA test. A Spearman’s correlation between the normalized lateral ventricle volume, a measure of organ-level CSF space, and the regional CSFF, a measure of tissue-level CSF space, was computed.

Results

Regression analyses showed that there was a statistically significant quadratic relationship with age for CSFF in the cortex (p= 0.018), MWF in the cerebral WM (p= 0.033), deep GM (p= 0.017) and cortex (p= 0.029); and IEWF in the deep GM (p= 0.033). There was a statistically highly significant positive linear relationship between age and regional CSFF in the cerebral WM (p< 0.001) and deep GM (p< 0.001). In addition, there was a statistically significant negative linear association between IEWF and age in the cerebral WM (p= 0.017) and cortex (p< 0.001). In the univariate correlation analysis, the normalized lateral ventricle volume correlated with the regional CSFF measurement in the cerebral WM (ρ = 0.64,p< 0.001), cortex (ρ = 0.62,p< 0.001), and deep GM (ρ = 0.66,p< 0.001).

Conclusion

Our cross-sectional data demonstrate that brain tissue water in different compartments shows complex age-dependent patterns. Parenchymal CSFF, a measure of subvoxel CSF-like water in the brain tissue, is quadratically associated with age in the cerebral cortex and linearly associated with age in the cerebral deep GM and WM.
Rescue therapy after thrombectomy for large vessel occlusion due to underlying atherosclerosis: review of literature
Authors: Khachatryan Tigran , Shafie Mohammad , Abcede Hermelinda , Shah Jay , Nagamine Masaki , Granstein Justin , Yuki Ichiro , Golshani Kiarash , Suzuki Shuichi , Yu Wengui
Published: June 2023

In this review article, we summarized the current advances in rescue management for reperfusion therapy of acute ischemic stroke from large vessel occlusion due to underlying intracranial atherosclerotic stenosis (ICAS). It is estimated that 24–47% of patients with acute vertebrobasilar artery occlusion have underlying ICAS and superimposed in situ thrombosis. These patients have been found to have longer procedure times, lower recanalization rates, higher rates of reocclusion and lower rates of favorable outcomes than patients with embolic occlusion. Here, we discuss the most recent literature regarding the use of glycoprotein IIb/IIIa inhibitors, angioplasty alone, or angioplasty with stenting for rescue therapy in the setting of failed recanalization or instant/imminent reocclusion during thrombectomy. We also present a case of rescue therapy post intravenous tPA and thrombectomy with intra-arterial tirofiban and balloon angioplasty followed by oral dual antiplatelet therapy in a patient with dominant vertebral artery occlusion due to ICAS. Based on the available literature data, we conclude that glycoprotein IIb/IIIa is a reasonably safe and effective rescue therapy for patients who have had a failed thrombectomy or have residual severe intracranial stenosis. Balloon angioplasty and/or stenting may be helpful as a rescue treatment for patients who have had a failed thrombectomy or are at risk of reocclusion. The effectiveness of immediate stenting for residual stenosis after successful thrombectomy is still uncertain. Rescue therapy does not appear to increase the risk of sICH. Randomized controlled trials are warranted to prove the efficacy of rescue therapy.
Clinical and cognitive correlates tractography analysis in patients with white matter hyperintensity of vascular origin
Authors: Kuang Qinmei , Huang Muhua , Lei Yumeng , Wu Lin , Jin Chen , Dai Jiankun , Zhou Fuqing
Published: June 2023

Purpose

White matter hyperintensity lesions (WMHL) in the brain are a consequence of cerebral small vessel disease and microstructural damage. Patients with WMHL have diverse clinical features, and hypertension, advanced age, obesity, and cognitive decline are often observed. However, whether these clinical features are linked to interrupted structural connectivity in the brain requires further investigation. This study therefore explores the white matter pathways associated with WMHL, with the objective of identifying neural correlates for clinical features in patients with WMHL.

Methods

Diffusion magnetic resonance imaging (MRI) and several clinical features (MoCA scores, hypertension scores, body mass index (BMI), duration of hypertension, total white matter lesion loads, and education.) highly related to WMHL were obtained in 16 patients with WMHL and 20 health controls. We used diffusion MRI connectometry to explore the relationship between clinical features and specific white matter tracts using DSI software.

Results

The results showed that the anterior splenium of the corpus callosum, the inferior longitudinal fasciculus, the anterior corpus callosum and the middle cerebellar peduncle were significantly correlated with hypertension scores (false discovery rate (FDR) = 0.044). The anterior splenium of the corpus callosum, the left thalamoparietal tract, the inferior longitudinal fasciculus, and the left cerebellar were significantly correlated with MoCA scores (FDR = 0.016). The anterior splenium of corpus callosum, inferior fronto-occipital fasciculus, cingulum fasciculus, and fornix/fimbria were significantly correlated with body mass index (FDR = 0.001).

Conclusion

Our findings show that hypertension score, MoCA score, and BMI are important clinical features in patients with WMHL, hypertension degree and higher BMI are associated with whiter matter local disconnection in patients with WMHL, and may contribute to understanding the cognitive impairments observed in patients with WMHL.
Regulation of mild cognitive impairment associated with liver disease by humoral factors derived from the gastrointestinal tract and MRI research progress: a literature review
Authors: Sun Tianning , Feng Maohui , Manyande Anne , Xiang Hongbing , Xiong Jun , He Zhigang
Published: June 2023

Patients with liver disease are prone to various cognitive impairments. It is undeniable that cognitive impairment is often regulated by both the nervous system and the immune system. In this review our research focused on the regulation of mild cognitive impairment associated with liver disease by humoral factors derived from the gastrointestinal tract, and revealed that its mechanisms may be involved with hyperammonemia, neuroinflammation, brain energy and neurotransmitter metabolic disorders, and liver-derived factors. In addition, we share the emerging research progress in magnetic resonance imaging techniques of the brain during mild cognitive impairment associated with liver disease, in order to provide ideas for the prevention and treatment of mild cognitive impairment in liver disease.
Clinical diagnostic biomarker “circulating tumor cells” in breast cancer - a meta-analysis
Authors: Bai Shiyan , Lin Shujin , Lin Ting , Wang Qiaowen , Cheng Cui , Lin Junru , Zhang Ying , Jiang Xiwen , Han Xiao
Published: June 2023

Objective

Using meta-analysis, we evaluate circulating tumor cells(CTCs) as a potential diagnostic tool for breast cancer.

Methods

A document search was conducted using publicly available databases up to May 2021. Specific inclusion and exclusion criteria were formulated and summarize relevant data through literature types, research types, case populations, samples, etc. Subgroup analysis of documents based on regions, enrichment methods, and detection methods. The included research projects were evaluated using DeeKs’ bias, and evaluation indicators such as specificity (SPE), sensitivity (SEN), diagnosis odds ratio (DOR) were used as evaluation indicators.

Results

16 studies on the use of circulating tumor cells to diagnose breast cancer were included in our meta-analysis. Overall sensitivity value was 0.50 (95%CI:0.48-0.52), specificity value was 0.93 (95%CI:0.92- 0.95), DOR value was 33.41 (95%CI:12.47-89.51), and AUC value was 0.8129.

Conclusion

In meta-regressions and subgroup analysis, potential heterogeneity factors were analyzed, but the source of heterogeneity is still unclear. CTCs, as a novel tumor marker, have a good diagnostic value, but its enrichment and detection methods still need to continue to be developed to improve detection accuracy. Therefore, CTCs can be used as an auxiliary means of early detection, which is helpful to the diagnosis and screening of breast cancer.
Normative echocardiography data of myocardial adaptation to extrauterine life: a review of prospective studies
Authors: Suciu Laura Mihaela , Prelipcean Irina , Făgărășan Amalia , Giesinger Regan E. , McNamara Patrick J.
Published: June 2023

Recent research has increased focus and interest in characterizing the physiology of the transition circulation using echocardiography. Critique of published normative neonatal echocardiography data among healthy term neonates has not been performed. We have performed a comprehensive literature review using the key terms: cardiac adaptation, hemodynamics, neonatal transition, term newborns. Studies were included if they had reported echocardiography indices of cardiovascular function in the presence of maternal diabetes, intrauterine growth restricted newborns and prematurity and had a comparison group of healthy term newborns within first seven postnatal days. Sixteen published studies evaluating transitional circulation in healthy newborns were included. There was marked heterogeneity in the methodologies used; specifically, inconsistency in time of evaluation and imaging techniques used makes it challenging to determine specific trends of expected physiologic changes. Some studies revealed nomograms for echocardiography indices, though limitations persist in terms of sample size, number of reported parameters and consistency of measurement technique. A comprehensive standardized echocardiography framework which includes consistent techniques for assessment dimensions, function, blood flow, pulmonary/systemic vascular resistance, and shunts pattern is warranted to ensure consistency in the use of echocardiography to guide care of healthy and sick newborns.
Correlation between hyperbilirubinemia risk and immune cell mitochondria parameters in neonates with jaundice
Authors: Wang Yingying , Wang Hongwei , Zhang Qiang , Li Shanshan , Mao Yiping , Lu Jiajin , Shen Yeqin , Han Yaping
Published: June 2023

Purpose

To explore the correlation between mitochondria parameters of immune cells and hyperbilirubinemia risk in hospitalized neonates with jaundice.

Methods

This retrospective study included jaundiced neonates born between September 2020 and March 2022 at Shaoxing Keqiao Women & Children's Hospital. The neonates were divided into low, intermediate-low, intermediate-high, and high-risk groups according to the hyperbilirubinemia risk. The purpose parameters including percentage, absolute count, mitochondrial mass (MM), and single-cell MM (SCMM) of peripheral blood T lymphocytes detected by flow cytometry were collected.

Results

Finally, 162 neonates with jaundice (47, 41, 39, and 35 with low, intermediate-low, intermediate-high, and high-risk) were included. CD3+ SCMM was significantly higher in the high-risk group compared with the low and intermediate-low-risk groups (both P < 0.0083), CD4+ SCMM was significantly higher in the high-risk group compared with the three other groups (all P < 0.0083), and CD8+ SCMM was significantly higher in the intermediate-low and high-risk groups compared with the low-risk group (both P < 0.0083). CD3+ (r = 0.34, P < 0.001) and CD4+ (r = 0.20, P = 0.010) SCMM positively correlated with bilirubin levels.

Conclusions

The mitochondrial SCMM parameters differed significantly among jaundiced neonates with different hyperbilirubinemia risks. CD3+ and CD4+ T cell SCMM values were positively correlated with the serum bilirubin levels, and might correlated with hyperbilirubinemia risk.
Effectiveness, quality and implementation of pain, sedation, delirium, and iatrogenic withdrawal syndrome algorithms in pediatric intensive care: a systematic review and meta-analysis
Authors: MacDonald Ibo , de Goumoëns Véronique , Marston Mark , Alvarado Silvia , Favre Eva , Trombert Alexia , Perez Maria-Helena , Ramelet Anne-Sylvie
Published: June 2023

Background

Pain, sedation, delirium, and iatrogenic withdrawal syndrome are conditions that often coexist, algorithms can be used to assist healthcare professionals in decision making. However, a comprehensive review is lacking. This systematic review aimed to assess the effectiveness, quality, and implementation of algorithms for the management of pain, sedation, delirium, and iatrogenic withdrawal syndrome in all pediatric intensive care settings.

Methods

A literature search was conducted on November 29, 2022, in PubMed, Embase, CINAHL and Cochrane Library, ProQuest Dissertations & Theses, and Google Scholar to identify algorithms implemented in pediatric intensive care and published since 2005. Three reviewers independently screened the records for inclusion, verified and extracted data. Included studies were assessed for risk of bias using the JBI checklists, and algorithm quality was assessed using the PROFILE tool (higher % = higher quality). Meta-analyses were performed to compare algorithms to usual care on various outcomes (length of stay, duration and cumulative dose of analgesics and sedatives, length of mechanical ventilation, and incidence of withdrawal).

Results

From 6,779 records, 32 studies, including 28 algorithms, were included. The majority of algorithms (68%) focused on sedation in combination with other conditions. Risk of bias was low in 28 studies. The average overall quality score of the algorithm was 54%, with 11 (39%) scoring as high quality. Four algorithms used clinical practice guidelines during development. The use of algorithms was found to be effective in reducing length of stay (intensive care and hospital), length of mechanical ventilation, duration of analgesic and sedative medications, cumulative dose of analgesics and sedatives, and incidence of withdrawal. Implementation strategies included education and distribution of materials (95%). Supportive determinants of algorithm implementation included leadership support and buy-in, staff training, and integration into electronic health records. The fidelity to algorithm varied from 8.2% to 100%.

Conclusions

The review suggests that algorithm-based management of pain, sedation and withdrawal is more effective than usual care in pediatric intensive care settings. There is a need for more rigorous use of evidence in the development of algorithms and the provision of details on the implementation process.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021276053, PROSPERO [CRD42021276053].
The history of Lyme disease in Italy and its spread in the Italian territory
Authors: Trevisan Giusto , Ruscio Maurizio , Cinco Marina , Nan Katiuscia , Forgione Patrizia , Di Meo Nicola , Tranchini Paolo , Nacca Massimo , Trincone Silvana , Rimoldi Sara Giordana , Giacomet Vania , Ricci Michela , Melandri Davide , Artioli Stefania , Monteforte Patrizia , Stinco Giuseppe , Bonin Serena
Published: June 2023

Lyme borreliosis (LB) is the most common vector-borne zoonotic inflammatory disease in the Northern Hemisphere. In Italy, the first case was diagnosed in 1985 in a woman in Liguria, while the second, in 1986 in Friuli-Venezia Giulia, documenting the infection in northern Italy. Both diagnoses were confirmed by serological assessment by an indirect immunofluorescence (IFI) technique. Borrelia cultivation from both Ixodes ricinus ticks and human lesions in Trieste (Friuli-Venezia Giulia) identified Borrelia afzelii as the prevalent genospecies; nevertheless, Borrelia garinii, Borrelia burgdorferi (sensu stricto), and Borrelia valaisiana (VS116 Group) were also detected, although less frequently. LB was also documented in other Italian regions: in Tuscany (1991), Trentino–Alto Adige (1995–1996), Emilia-Romagna (1998), Abruzzo (1998), and more recently, Lombardy. Nevertheless, data on LB in other Italian regions, especially in southern Italy and islands, are poor. The aim of this study is to document the spread of LB in Italy through the collection of data from LB patients in eight Italian hospitals located in different Italian regions. Diagnostic criteria for LB diagnosis are as follows: i) the presence of erythema migrans (EM) or ii) a clinical picture suggestive of LB, confirmed by serological tests and/or PCR positivity for Borrelia detection. In addition, data also included the place of residence (town and region) and the place where patients became infected. During the observation period, 1,260 cases were gathered from the participating centers. Although different in extent from northern Italy to central/southern Italy, this study shows that LB is widespread throughout Italy.
Development of holographic printed HOE recording technology with VHG-based FOV analysis for waveguide-type NED system
Authors: Hwang Leehwan , Lee Seunghyun
Published: June 2023

We propose a holographic printing–recording technology for near-eye display through volume holographic grating analysis in hologram recording and reconstruction. Most near-eye displays are designed based on waveguide-type and analog holographic optical elements, resulting in disruption of the uniformity of the image because of the difference between the initial recording conditions and the source image. This problem can be addressed using holographic printing technology to modulate different diffraction efficiencies for each holographic element. This study uses a digital HOE screen that can fabricate and reconstruct augmented reality images of 1.17”, 1.76”, and 2.35” in a field of view of 28.07°, 41.11°, and 53.13°, respectively, at a distance of 53.33 mm from the eye. Moreover, augmented images are realized with higher diffraction efficiency than conventional methods, simplifying the design and facilitating mass production of uniformed products using digital holographic printing technology.
Mapping and validation of a novel major QTL for resistance to stripe rust in four wheat populations derived from landrace Qishanmai
Authors: Jiang Xu , Wang Zhen , Feng Jing , Du Ziyi , Zhang Zhongjun , Zhang Yibin , Che Mingzhe , Ren Junda , Wang Haiguang , Quan Wei
Published: June 2023

Wheat yield has been constrained by stripe rust disease globally. A wheat landrace (Qishanmai, QSM) consistently showed lower stripe rust severities in multiple year studies than susceptible check varieties including Suwon11 (SW) at the adult plant stage. To detect QTL for reducing the severity in QSM, 1218 recombinant inbred lines (RILs) were developed from SW × QSM. QTL detection was conducted firstly using 112 RILs selected for similarity in pheno-morphological characters. The 112 RILs were assessed for stripe rust severity at the 2nd leaf, 6th leaf and flag leaf stages under field and greenhouse conditions, and genotyping was done primarily with a single nucleotide polymorphism (SNP) array. On the basis of these phenotypic and genotypic data, a major QTL (QYr.cau-1DL) was detected on chromosome 1D at the 6th leaf and flag leaf stages. Further mapping was conducted by genotyping 1218 RILs using new simple sequence repeat (SSR) markers, which were developed by referring to the sequences of the wheat line Chinese Spring (IWGSC RefSeq v1.0). QYr.cau-1DL was mapped within a 0.5 cM (5.2 Mb) interval delimited by the SSR markers 1D-320.58 and 1D-325.79. These markers were applied to select for QYr.cau-1DL by screening F2 or BC4F2 plants of the wheat crosses RL6058 × QSM, Lantian10 × QSM and Yannong21 × QSM. F2:3 or BC4F2:3 families derived from the selected plants were assessed for stripe rust resistance in the fields of two locations and in a greenhouse. Wheat plants carrying the resistant marker haplotype in homozygous state for QYr.cau-1DL showed lower stripe rust severities (by 44% to 48%) than plants lacking this QTL. The trial of RL6058 (a carrier of Yr18) × QSM also indicated that QYr.cau-1DL had larger effect than Yr18 on reducing severity; they acted synergistically, yielding an elevated level of stripe rust resistance.
Political socialization, parental separation, and political ideology in adulthood
Authors: van Ditmars Mathilde M. , Bernardi Fabrizio
Published: June 2023

The increase in divorce rates over the past decades challenges the traditional image of the two-parent family, as new family forms are increasingly more common. Yet, the traditional view of the family has remained central to political socialization research. Therefore, we propose and empirically test a theoretical framework regarding the consequences of parental separation for processes of political socialization. While the impact of parental divorce has been studied extensively by sociologists, the political implications of this impactful life event have remained largely uncovered. We identify two mechanisms that we expect to predict more leftist political orientations in children of separated parents compared to those from intact families: experiences of economic deprivation and single-mother socialization. Multi-level analyses using the European Values Study (2008) and two-generational analyses with the Swiss Household Panel (1999–2020) support our expectations, indicating that in case of parental separation offspring tends to hold more leftist political orientations, controlling for selection into parental separation and the intergenerational transmission of political ideology. We find empirical support for mechanisms of economic deprivation and single-mother socialization across our analyses. The implications of our findings are that in the family political socialization process, offspring's political orientations are not only influenced by their parents' ideology, but also by formative experiences that result from the family structure.
Prevalence of frailty and pre-frailty and related factors in older adults with cardio-cerebral vascular disease in China: a national cross-sectional study
Authors: Zeng Xue-zhai , Meng Ling-bing , Jia Na , Shi Jing , Zhang Chi , Li Ying-ying , Hu Xing , Hu Jia-bin , Li Jian-yi , Wu Di-shan , Li Hui , Qi Xin , Wang Hua , Zhang Qiu-xia , Li Juan , Liu De-ping
Published: June 2023

Objective

Frailty increases adverse clinical outcomes in older patients with cardio-cerebral vascular disease (CCVD). The aim of this study was to investigate the prevalence of frailty and pre-frailty in older adults with CCVD in China and the factors associated with it.

Research design and methods

In this cross-sectional study, we used data from the fourth Sample Survey of Aged Population in Urban and Rural China. We used the frailty index for frailty and pre-frailty assessment, and the diagnosis of CCVD in older adults was self-reported.

Results

A total of 53,668 older patients with CCVD were enrolled in the study. The age-standardized prevalence of frailty and pre-frailty in older patients with CCVD was 22.6% (95% CI 22.3–23.0%) and 60.1% (95% CI 59.7–60.5%). Multinomial logistic regression analyses showed that being female, increasing age, rural residence, illiteracy, widowhood, ethnic minority, living alone, no health screening during the last year, hospitalization during the last year, difficult financial status, comorbid chronic conditions, and disability in activities of daily living were associated with frailty and pre-frailty in older patients with CCVD.

Conclusion

CCVD is strongly associated with frailty and pre-frailty in older Chinese people, and assessment of frailty should become routine in the management of older CCVD patients. Appropriate public health prevention strategies should be developed based on identified risk factors for frailty in older CCVD patients, which can help prevent, ameliorate or reverse the development of frailty in CCVD in the older population.
Everyday life during the childhood cancer trajectory—childhood cancer survivors' descriptions of the role of caring support
Authors: Stenmarker Margaretha , Björk Maria , Golsäter Marie , Enskär Karin
Published: June 2023

Background

Being diagnosed with cancer in childhood often has a direct impact on the child's opportunities to participate in activities and the child's sense of belonging in different life situations. Experiences of illness in youth affect the lives of these individuals in numerous ways and they need pronounced support to regain their normal life after treatment.

Purpose

To illustrate how childhood cancer survivors describe the role of the caring support provided by healthcare professionals at diagnosis and during the cancer trajectory.

Methods

A mixed methods approach was applied. Swanson's Theory of Caring was used to deductively analyze the answers in a study-specific questionnaire with Likert scales (1–5). Descriptive and comparative statistics and exploratory factor analyses were performed.

Results

Sixty-two former patients, diagnosed with solid tumors/lymphoma in 1983 to 2003 in Sweden, participated. The mean time passed since treatment was 15.7 years. Swanson's caring processes Being with and Doing for were the most prominent loading categorical factor indicators. Higher scores for healthcare professionals being emotionally present (Being with), doing for others what they would do for themselves (Doing for) and being willing to understand the sick child's situation (Knowing) were highlighted by survivors older than 30 years, compared to those younger than 30 years (p = 0.041, p = 0.045, and p = 0.013, respectively). An increased vulnerability regarding their ability to cope with difficulties (Maintain belief) was found among participants who were treated during adolescence, related to schoolchildren (p = 0.048), and among those who had been treated with extra-cranial irradiation in comparison with no extra-cranial irradiation (p = 0.004). The role of having a partner in comparison with being single was underlined among those who felt they had acquired the tools they needed to take care of themselves (Enabling) (p = 0.013). The total explained variance was 63%.

Conclusions

A person-centered care approach during treatment for childhood cancer, reflected by a caring model, highlights the role of healthcare professionals being emotionally present, involving children, performing actions, and with an approach that has potential long-term implications. Childhood cancer patients and survivors need not only clinically competent professionals, but professionals who provide caring interactions with compassion.
Content validity, interpretability, and internal consistency of the “Quality First” assessment to evaluate movement quality in hop tests following ACL rehabilitation. A cross-sectional study
Authors: Mathieu-Kälin Moritz , Müller Mirjam , Weber Melanie , Caminada Sandro , Häberli Marina , Baur Heiner
Published: June 2023

Introduction

Current approaches fail to adequately identify sport readiness after anterior cruciate ligament (ACL) rehabilitation. Altered landing biomechanics after ACL reconstruction are associated with increased risk of a noncontact ACL reinjury. There is a lack of objective factors to screen for deficient movement patterns. Therefore, the aim of this study was to investigate content validity, interpretability, and internal consistency for the newly developed “Quality First” assessment to evaluate movement quality during hop tests in patients after ACL rehabilitation.

Method

Participants in this cross-sectional study were recruited in collaboration with the Altius Swiss Sportmed Center in Rheinfelden, Switzerland. After a successful ACL reconstruction, the movement quality of 50 hop test batteries was evaluated between 6 and 24 months postoperatively with the “Quality First” assessment. Content validity was assessed from the perspective of professionals. To check the interpretability, classical test theory was employed. Cronbach's α was calculated to evaluate internal consistency.

Results

Content validity resulted in the inclusion of three different hop tests (single-leg hop for distance, vertical hop, and side hop). The “Quality First” assessment is enabled to evaluate movement quality in the sagittal, vertical, and the transversal plane. After the exclusion process, the “Quality First” assessment was free from floor and ceiling effects and obtained a sufficient Cronbach's α. The final version consists of 15 items, rated on a 4-point scale.

Discussion

By means of further validations, the “Quality First” assessment could offer a possibility to evaluate movement quality after ACL rehabilitation during hop tests.