bluuebunny/crossref_metadata_2025 huggingface dataset:
Epistasis between mutator alleles contributes to germline mutation rate variability in laboratory mice
Authors: Sasani Thomas A. , Quinlan Aaron R. , Harris Kelley
Published: July 2023

Maintaining germline genome integrity is essential and enormously complex. Hundreds of proteins are involved in DNA replication and proofreading, and hundreds more are mobilized to repair DNA damage [1]. While loss-of-function mutations in any of the genes encoding these proteins might lead to elevated mutation rates,
mutator alleles
have largely eluded detection in mammals.DNA replication and repair proteins often recognize particular sequence motifs or excise lesions at specific nucleotides. Thus, we might expect that the spectrum of
de novo
mutations — that is, the frequency of each individual mutation type (C>T, A>G, etc.) — will differ between genomes that harbor either a mutator or wild-type allele at a given locus. Previously, we used quantitative trait locus mapping to discover candidate mutator alleles in the DNA repair gene
Mutyh
that increased the C>A germline mutation rate in a family of inbred mice known as the BXDs [2, 3].In this study we developed a new method, called “inter-haplotype distance,” to detect alleles associated with mutation spectrum variation. By applying this approach to mutation data from the BXDs, we confirmed the presence of the germline mutator locus near
Mutyh
and discovered an additional C>A mutator locus on chromosome 6 that overlaps
Ogg1
and
Mbd4
, two DNA glycosylases involved in base-excision repair [4, 5]. The effect of a chromosome 6 mutator allele depended on the presence of a mutator allele near
Mutyh
, and BXDs with mutator alleles at both loci had even greater numbers of C>A mutations than those with mutator alleles at either locus alone.Our new methods for analyzing mutation spectra reveal evidence of epistasis between germline mutator alleles, and may be applicable to mutation data from humans and other model organisms.
Students Satisfaction with the Laboratory Services and Facilities in the College of Business Laboratory Areas
Authors: Neri Violeta , Necesario Kristine Rose , Faniega Frances Joy
Published: July 2023

Bachelor of Science in Hospitality Management major in Cruise Ship Services is one of the programs offered by John B. Lacson Colleges Foundation-Bacolod. This program provides higher education for students to advance their knowledge and a complete set of facilities for students to use. Several studies addressed the issue of delivering service quality in higher education due to the increasing number of enrollees. As the school undergoes accreditation with the Philippine Association of Colleges and Universities Commission on Accreditation, it seeks to assess if the program meets the stringent requirements continually; hence, it is crucial to carry out this research. The study’s main objective was to determine student satisfaction with the services and facilities in the College of Business’ laboratory areas. This study was participated by 159 BSHM students. A research-made survey questionnaire was utilized through the use of Google Forms. Frequency count, rank, mean, standard deviation, one-way ANOVA, and Pearson Product Moment Correlation were utilized in the data analyses. The findings showed that the expected service quality attributes, when taken as a whole and when students are grouped according to year level and section, are very much visible. The study revealed a very highly satisfying quality of services in the laboratory area.
Influence of Pre and In-Service Training Programs of the Kindergarten Teachers in the Implementation of the Kindergarten Curriculum
Authors: Santos Resa Dee
Published: July 2023

This study investigated the significant relationship between the extent of pre-and in-service training of kindergarten teachers and their performance ratings in 2020-2022. The profile of teachers was identified, which focuses on educational attainment, number of years in teaching and in-service and pre-service seminars attended by teachers, the extent of the pre and in-service trainings, and their performance ratings in two consecutive years. This study employed a non-experimental correlational research design, and the respondents were the 385 kindergarten teachers in the Division of Sarangani. The results showed that 70.87% are non-Early Childhood Education graduates and 17.47% of the kindergarten teachers are pursuing master's degrees, not specializing in Early Childhood Education, and 7.77% are pursuing master's degrees specializing in Early Childhood Education. Findings revealed that the pre-service trainings of kindergarten teachers are less extensive. However, the in-service trainings for kindergarten teachers are highly extensive. The performance rating of the kindergarten teachers in the two school years is Very Satisfactory. There was a strong significant relationship between the extent of pre and in-service teachers' training and their performance rating in the two school years. With the results of the study, it is recommended that teachers teaching kindergarten should pursue a master's degree specializing in Early Childhood Education. Also series of trainings and seminars should also be conducted to help kindergarten teachers improve their performances.
Sales forecasting using machine learning algorithms
Authors: Martins Emerson , Galegale Napoleão Verardi
Published: July 2023

Retail companies, as production systems, must use their resources efficiently and make strategic decisions to obtain growing and stable revenues, especially when market conditions are becoming more competitive and profit margins are increasingly pressured. Thus, sales forecasting is crucial to maintain competitiveness in the retail segment, but obtaining inaccurate forecasts can lead to stock shortages, causing delays in deliveries and generating customer dissatisfaction, as well as increasing inventory, increasing the cost of warehousing, forcing the “burn” of stock through promotional campaigns, directly affecting profitability. Forecasting the demand for products and services and adapting the supply chain by finding a balance has always been and will continue to be a challenge in the retail segment. This research aims to evaluate the main methods and identify the one with the greatest accuracy in sales prediction. Based on an integrative literature review (ILR), three main methods were evaluated: time series, artificial neural networks and machine learning algorithms. The results show that machine learning is more suitable in terms of accuracy, particularly when models contain exogenous and endogenous variables, in addition to allowing the identification of hidden patterns in demand that can be used to identify market trends. However, in markets with constant demands and few external interferences, its use is not justified because, for these cases, the use of time series is simpler and less costly.
Glycaemic Control of Type 1 Diabetes Mellitus Paediatric Patients before and after the Use of Telephonic Reinforcement: A Prospective Interventional Study at a Tertiary Care Hospital, Western India
Authors: Jhala Jayati Joshipura , Patel Alpaben , Pankhaniya Rajesh N , Bhadesia Vatsal H
Published: July 2023

Introduction: Type 1 Diabetes Mellitus (T1DM) is one of the most common paediatric endocrine illnesses. It is a chronic condition that involves regular administration of insulin, meal planning, strict adherence to physical activity and home-based sugar monitoring. Regular follow-up is essential to prevent short-term and long-term complications. Telemedicine has been extensively used in the management of multiple chronic conditions in adults. However, there are limited studies showing the impact of telemedicine in T1DM paediatric patients in the Indian population. Aim: To compare the glycaemic control in paediatric T1DM patients, before and after the use of telephonic reinforcement. Materials and Methods: A prospective, interventional study was conducted at Shree Krishna Hospital, Karamsad, Gujarat, India with no sub-specialty clinic. The duration of the study was one year and five months, from November 2017 to April 2019. Paediatric patients upto the age of 18 years, diagnosed with T1DM (by paediatricians/physicians) were included in the study. The records of 64 patients were traced, 27 were enrolled prospectively for the study (who could be contacted and consented to the present study). The baseline weight, height, age, duration of T1DM, insulin dosage and baseline Glycosylated Haemoglobin (HbA1c) were recorded. Majority of the patients 24 (89.4%) from rural area belonged to lower socioeconomic class, belonging to lower socioeconomic class. After receiving due consent, the patients/parents were provided telephonic reinforcement by a paediatrician to ensure regular sugar monitoring, solve queries of parents and to ensure regular follow-up. The clinical profile and parameters were repeated at three monthly intervals and compared. A paired t-test was used with a p-value=0.05 as a cut-off to compare data before and after intervention. Results: The mean and median ages of the study participants at diagnosis were found to be 8.9 years and 10.5 years, respectively. Average duration of T1DM was four years. On telephone, three things were reinforced: 1) To take insulin regularly as advised; 2) To come for follow-up regularly and 3) If any difficulties faced by them while taking insulin or coming for follow-up then to contact us. The patients were followed-up as per routine, diabetic care protocol every three months and value of HbA1c was reduced significantly during follow-up. The (p-value<0.001) showed a significant difference after telephonic reinforcement. Conclusion: Telephonic reinforcement improves control of T1DM, by improving laboratory parameters and compliance with regular follow-up.
Cumulative Effect of Fertilizer and Organic Spray (Banana Pseudostem Sap or Vermiwash) on Yield, Quality, Uptake and Economics of Linseed (Linum usitatissimum L.)
Authors: Kotadiya R. H. , Ardeshna R. B. , Patel D. J. , Kachhiyapatel K. A. , Birla Devilal
Published: July 2023

The study on linseed aimed to investigate the effectiveness of fertilizer and organic spray of banana pseudostem sap or vermiwash on yield, quality, uptake and economics of the crop was conducted at College Farm, N. M. College of Agriculture, Navsari Agricultural University, Navsari during rabi season of 2019-20. The experiment was laid out in Randomized Block Design with four replicates. The experimental field was fairly leveled and uniform. The treatments comprising of T1(50% RDF),T2 (50% RDF + Foliar spray of 1% vermiwash at 30 and 60 DAS), T3 (50% RDF + Foliar spray of 1% banana pseudostem sap at 30 and 60 DAS), T4(75% RDF), T5 (75% RDF + Foliar spray of 1% vermiwash at 30 and 60 DAS), T6 (75% RDF + Foliar spray of 1% banana pseudostem sap at 30 and 60 DAS), T7(100% RDF),T8 (100% RDF + Foliar spray of 1% vermiwash at 30 and 60 DAS) and T9(100% RDF + Foliar spray of 1% banana pseudostem sap at 30 and 60 DAS).The result indicated significant differences on seed yield, oil yield and nutrient uptake in the seed and stover. Treatment T9 outperformed the other treatments by registering maximum yield, oil yield and nutrient uptake in the seed and stover, gross return, net return and benefit cost ratio.  It could be concluded that to obtain better yield, quality, uptake and economics of rabi linseed crop the crop should be applied with 100% RDF(60-30-00 N-P2O5-K2O kg ha-1) and foliar spray of 1% vermiwash or 1% banana pseudostem sap at 30 and 60 DAS.
The C. elegans truncated insulin receptor DAF-2B regulates survival of L1 arrested larvae
Authors: Martinez Bryan A. , Gill Matthew S.
Published: July 2023

We have previously characterized a truncated isoform of the C. elegans insulin-like receptor, DAF-2B, which retains the ligand binding domain but cannot transduce a signal due to the absence of the intracellular signaling domain. DAF-2B modifies insulin / insulin-like growth factor signaling-dependent processes, such as dauer formation and lifespan, by sequestering insulin-like peptides (ILP) and preventing signaling through full length DAF-2 receptors. Here we show that DAF-2B is also important for starvation resistance, as genetic loss of daf-2b reduces survival in arrested first stage larvae (L1). Under fed conditions, we observe daf-2b splicing capacity in both the intestine and the hypodermis, but in starved L1s this becomes predominantly hypodermal. Using a novel splicing reporter system, we observe an increase in the ratio of truncated to full length insulin receptor splicing capacity in starved L1 larvae compared with fed, that may indicate a decrease in whole body insulin responsiveness. Consistent with this, overexpression of DAF-2B from the hypodermis, but not the intestine, confers increased survival to L1 animals under starvation conditions. Our findings demonstrate that the truncated insulin receptor DAF-2B is involved in the response to L1 starvation and promotes survival when expressed from the hypodermis.
El maestro ondas en el departamento del Caquetá
Authors: Hernandez Gil Cristian , Cardozo Jiménez Carol Jennifer , PERDOMO ROJAS LADDY TATIANA PERDOMO ROJAS
Published: July 2023

Objetivo: determinar la incidencia generada en el docente que participa en el Programa Ondas (Minciencias), con sus estudiantes a través de grupos de investigación desde el desarrollo de sus prácticas pedagógicas en el departamento del Caquetá. Metodología: Se realizó un estudio de enfoque mixto, diseño no experimental transversal y descriptivo. Participaron 171 docentes de dieciséis municipios de la región en mención, a través de la aplicación de entrevistas. Resultados: Consideran dos tipos de incidencias. Por un lado, el componente de desarrollo profesional que lleva al docente a mejorar su perfil académico e investigativo. Por otro lado, el componente educativo que promueve prácticas pedagógicas novedosas para guiar la enseñanza y facilitar el aprendizaje. Conclusiones: La principal inferencia producto de este estudio es la continuidad del Programa dentro de las estrategias de desarrollo de los territorios en cada departamento de Colombia.
PROSPECTIVE VISION OF SUSTAINABLE ECONOMIC DEVELOPMENT AND STRATEGIC DIRECTIONS IN AZERBAIJAN
Authors: AGASALİM Alasgarova Aygun
Published: July 2023

The relevance of the scientific article is justified by observation of the interdependence between the environment and long-term economic stability, characteristic of the Azerbaijani market relations in the form of relatively volatile changes. Consequently, the opportunities for improving the competitiveness of the economy, the quality of life of the population, the level of investment attractiveness, the innovative focus of investment while ensuring sustainable economic development have been studied in the article. The main idea of this article encompasses summarization of the opinions on optimizing the productivity of sustainable development through rational activity and the reduction of high risks in the global economy. The purpose of the work comprises identification of effective ways of strengthening the national economy and its integration into the world economic system and their implementation, adapting them to the socio-economic situation of the country on the basis of global development trends. The methodology of the research consists of studies conducted by local and foreign experts in the fields of macroeconomic development, scientific and technological progress, research on the problems of innovation economy in the information society, statistical information and analyzes on production and foreign trade. Some proposals for activities to be implemented in the framework of state programs adopted to ensure sustainable development are presented as a result of the study. Scientific novelty of the article includes establishment of tasks to be decided on strategic targets for sustainable development, showing the model of work with innovations, as well as determination of the conformity quality required for productive activities in the form of picture.
Organizational creativity and remote working in the deployment of COVID- 19 in Saudi Arabia
Authors: Almasradi Rajeh Bati , Romdhane Mohamed , Triki Mohamed Bilel
Published: July 2023

The objective of this research is to examine and assess the impact of the initial experiences of remote working in Saudi Arabia during the COVID-19 pandemic. Specifically, the study focuses on investigating the extent to which remote working in various economic and administrative sectors in Saudi Arabia has influenced organizational creativity. The research follows an exploratory approach, benefiting from unique insights obtained through a questionnaire distributed among employees of both Saudi and international companies. The questionnaire is designed around four key dimensions: changes in working practices, knowledge-creation processes, remote working, and organizational creativity. The methodology employed in this study involves weighted logistic regression to analyze the relationship between remote working and organizational creativity. The findings demonstrate that certain factors, such as learning, trust, autonomy, and remote working itself, have a positive impact on organizational creativity. These factors facilitate the independent generation of innovative and valuable ideas for services or products. On the other hand, centralization within organizations appears to discourage creative work. In conclusion, this research sheds light on the effects of remote working in Saudi Arabia during the COVID-19 pandemic and highlights the significance of factors that contribute to organizational creativity in the context of remote work. The findings have implications for businesses and policymakers seeking to promote creativity and innovation within their organizations during times of remote work arrangements.
Hamiltonian Monte Carlo for the Purpose of Induced Source Characterization: Application to an ML 3.4 Event in the Groningen Gas Field
Authors: Masfara La Ode Marzujriban , Weemstra Cornelis
Published: July 2023

Hamiltonian Monte Carlo (HMC) is known to be highly efficient when
sampling high-dimensional parameter spaces. This high efficiency can be
attributed to Hamilton’s equations, which guide the sampling of the
model space. In the case of weakly non-linear problems, this efficiency
can be increased even further by linearizing the forward problem. In
this study, we exploit this for the purpose of estimating source
parameters of a 3.4 magnitude induced event that originated in the
Groningen gas field in 2019. In total, we estimate ten earthquake
parameters: centroid (three coordinate components), moment tensor (six
elements), and origin time. We demonstrate that, in the absence of a
sufficiently accurate centroid prior, the linearization of the forward
model necessitates multiple initial centroid priors. Here, we consider
two sets of initial centroid priors. The first set is based on the known
fault geometry in the Groningen reservoir, whereas the second set is
obtained by placing initial centroid priors on a uniform horizontal grid
at a depth of 3 km (the approximate depth of the gas reservoir). In
general, the results from both sets are in good agreement with each
other. Most important, however, is their agreement with the geological
knowledge of the area: the posterior peaks for model vectors containing
a centroid near a major fault and a moment tensor that corresponds to
normal faulting along a plane which has a strike almost coinciding with
the strike of that major fault.
El fin del amor en El desprecio de Godard
Authors: Gutiérrez Ñahui Sha Sha
Published: July 2023

Este ensayo reflexiona sobre el origen del desprecio de Camille a Paul en El desprecio de Godard. Considerando la relectura de la Odisea planteada en el filme, se estudiará la crisis de esta pareja desde una perspectiva sociológica y desde la teoría de los afectos. En ese sentido, se analizará cómo se forma la imaginación romántica de ambos personajes, lo que permitirá entender sus expectativas y desencuentros.
Đánh giá rủi ro
Authors: Nguyen Minh Ky
Published: July 2023

Đánh giá rủi ro và khía cạnh môi trường
The Impact of Synchronous and Asynchronous Learning on Academic Integrity Violations by University Students
Authors: Prihatiningtias Yeney Widya , Rahmat Muhammad Aldi Alif
Published: July 2023

This study intends to investigate the impact of synchronous and asynchronous online learning on the occurrence of academic ethical infractions among students. The object of this research is an active student of Bachelor Degree in the Department of Accounting, Faculty of Economics and Business, Universitas Brawijaya. A total of 354 data were collected using a survey method with purposive sampling technique. Data analysis was performed using the SPSS application. The test results show that synchronous online learning has an effect on students' academic ethics violations. In addition, the test results also show that asynchronous online learning has an effect on violations of student academic ethics. The findings are consistent with the Fraud Triangle Hypothesis, which contends that when fraud is possible, cases of academic ethical infractions become more serious.
Klasterisasi Komentar Cyberbullying Masyarakat di Instagram berdasarkan K-Means Clustering
Authors: Ramadhan Viry Puspaning , Namung Giasinta Mareskoti
Published: July 2023

Cyberbullying termasuk dalam salah satu tindak kekerasan yang dilakukan oleh seorang pengguna social media terhadap korbannya di dunia maya, dimana korban dicaci, diejek, dihina, bahkan diintimidasi dan dipermalukan oleh pelaku. Analsis sentimen dikenal juga dengan proses analisis teks untuk menentukan sentimen atau opini yang diungkapkan oleh penulis. Hal ini melibatkan penggunaan teknik pemrosesan bahasa alami untuk mengekstrak informasi subjektif dari teks dan mengkategorikannya sebagai positif, negatif, atau netral. Beberapa studi sebelumnya membahas tentang analisis sentiment opini wisata pantai di twitter menggunakan metode k-means untuk mengelompokkan opini masyarakat tersebut ke dalam kategori opini baik, buruk, dan sangat buruk. Pada penelitian tersebut penulis menggunakan metode support vector machine untuk pengklasifikasian opini kemudian menggunakan algoritma k-means untuk clusterisasi opini. Hasil dari klasifikasi tersebut mendapatkan akurasi sebesar 74,39%. Dalam artikel ini melalui analisis klasterisasi, kita dapat memperoleh klasifikasi komentar cyberbullying di Instagram dan juga dapat menvisualisasikan emosi yang terkandung dalam setiap korpus melalui orange data mining.
The History and the Identity of Dental Hygiene
Authors: Hwang Yoon-Sook , Heo So-Yun
Published: July 2023

This article explores the identity of modern dental hygiene through an examination of the history of oral hygiene. Until the 18th century, the cleansing of one’s mouth was done mainly to remove halitosis or whiten teeth. Prior to the advent of ‘dental hygiene,’ types of behavior that could be considered as acts of oral hygiene were driven by instinctive and preference-oriented demands of individuals and cultures. The view that proper dental hygiene, including the removal of dental calculus and food debris, could be helpful in preventing dental diseases arose only after the invention of the microscope and the discovery of oral microbiome. ‘Mouth Cleaning,’ which had usually been done by barbers and barber-surgeons until the 18th century, evolved into dental hygiene services, including ‘tooth brushing instruction (TBI),’ ‘gum management,’ or ‘scaling’ based on scientific evidence. Although science was instrumental in making preventive dentistry the main function of modern dental hygiene, there is a lack of research on the historical and philosophical roots of the profession of dental hygiene. This article contributes to this new line of research by providing narrative accounts of oral hygiene from a social and cultural perspective. It is hoped that this research will help to shape a new paradigm for dental hygiene.
Профессиональная осознанность
Authors: Torshina D. E.
Published: July 2023

Данное методическое пособие адресовано руководителям, заместителям руководителей, методистам и педагогам учреждений дополнительного образования. На основе анализа и обобщения научной литературы кратко изложены основные аспекты организации сопровождения профессионально-личностного развития молодого педагога, а также представлен содержательный материал для проведения как групповых тренинговых мероприятий, так и самостоятельного рефлексивного анализа, основанного на принципах методики трансформационного (преобразующего) обучения. Методическое пособие представляет практическую значимость для административных и педагогических работников учреждений дополнительного образования, имеющих цель организации процесса сопровождения профессионально-личностного развития педагога.
Effect of the Board of Commissioners, Capital Intensity, Profitability, and Audit Committee on Tax Avoidance with Firm Size as a Moderating Variable in Food and Beverage Companies Listed on the IDX
Authors: Wahana Prawira , . Erlina , Yahya Idhar
Published: July 2023

This study aims to determine the effect of the board of commissioners, capital intensity, profitability, and audit committee on tax evasion. In addition, this study aims to determine whether firm size can be used as a moderating variable in the model.
The research design carried out is a causal relationship research with a quantitative approach. The type of data used in this research is secondary data. The technique of determining the sample is using purposive sampling. The samples obtained in this study were 22 manufacturing companies listed on the IDX from 2017 to 2021. The data analysis technique used was panel data regression analysis and interaction (moderating) testing. The results in this study indicate that partially the board of commissioners and capital intensity have a negative and significant effect on tax evasion. Profitability and audit committees have a positive and significant effect on tax avoidance. Meanwhile, firm size cannot moderate the board of commissioners, capital intensity, and audit committee on tax avoidance. Firm size can moderate profitability on tax avoidance in food and beverage companies listed on the Indonesia Stock Exchange.

Keywords: board of commissioners, capital intensity, profitability, firm size, tax avoidance
Propuesta de medidas preventivas ante inundaciones. Caso Barrio Reina del Cisne de Cariamanga, Provincia de Loja
Authors: Maza Collaguazo Jessica Viviana , Ochoa Tapia Maritza Ximena , Castillo García Hernán Luis , Paladines Jymmy Stalin
Published: July 2023

Las inundaciones son los fenómenos naturales más peligrosos debido a su recurrencia, y a los efectos dejados en los sectores sociales y económicos, lo que genera un retraso en el desarrollo de una comunidad o de una nación. La presente investigación realiza la propuesta de dos medidas preventivas ante inundaciones, la primera enfocada en fortalecer la resiliencia de la población, mediante el diseño y socialización de un plan comunitario de gestión de riesgos; y la segunda enfocada a la implementación de una estación hidrométrica, con el fin de realizar el monitoreo a la quebrada Totoras y prevenir de manera oportuna a la población expuesta sobre las posibles inundaciones generadas por aun aumento de caudal y desbordamiento de la quebrada. Para proponer la ubicación de la estación hidrométrica fue necesario realizar la zonificación de amenazas por inundaciones de la microcuenca las Totoras, mediante un análisis multicriterio empleado el modelo jerárquico de Saaty; e identificar los elementos expuestos, para determinar el lugar idóneo de su ubicación.
Aplicación web para la gestión del arbolado urbano de la ciudad de Loja
Authors: González Guamán Johnny Fabián , Chamba-Zaragocin Wilman , Cumbicus-Pineda Oscar M.
Published: July 2023

En respuesta a la creciente preocupación por la gestión sostenible de los árboles urbanos, numerosas ciudades del país se encuentran buscando soluciones efectivas. Como resultado, diversas instituciones del sector público están formulando e implementando políticas destinadas a la conservación, uso y manejo adecuado de los árboles en entornos urbanos. En este contexto, se llevó a cabo el proyecto de investigación forestal titulado "Dinámica de crecimiento y servicios ecosistémicos del arbolado urbano de la ciudad de Loja". Su objetivo principal fue desarrollar un inventario completo y actualizado de los árboles dentro de los límites de la ciudad, proporcionando así una herramienta fundamental para futuras investigaciones y toma de decisiones. Para lograr este propósito, se diseñó y desarrolló una aplicación especializada capaz de gestionar eficientemente los datos científicos y técnicos recopilados por los investigadores. La metodología utilizada para el desarrollo de la aplicación se basó en ICONIX, que permitió establecer modelos arquitectónicos lógicos y físicos representados mediante diagramas UML. Posteriormente, se implementaron estos modelos utilizando un enfoque n-tier, dividiendo la aplicación en capas lógicas y físicas. Para ello, se emplearon tecnologías como JavaScript, React, Mapbox, Node, Express, Sequelize y MySQL, tanto para el backend como para el frontend de la aplicación. Esta combinación de tecnologías garantizó un desarrollo eficiente y una interfaz de usuario intuitiva y atractiva. Una vez completada la implementación, se llevaron a cabo exhaustivas pruebas de caja negra y pruebas funcionales, las cuales fueron sometidas a la validación del director del proyecto de investigación. Se verificó que la aplicación funcionara correctamente y cumpliera con los requisitos establecidos. Además, se realizaron pruebas de los servicios API-REST para asegurar la compatibilidad e integración adecuada con posibles futuras aplicaciones.
Strategies for informing the population of the republic of Moldova on the problem of human trafficking
Authors: Alistratova Oxana
Published: July 2023

Having entered the global migration processes, from the second half of the 1990s, the Republic of Moldova faced the problem of human trafficking and became a country of origin for victims of human trafficking. One of the important measures aimed at preventing human trafficking is the awareness of the population, primarily young people, about the risks and consequences of human trafficking. The education system plays an important role in raising citizens’ awareness of the risks and consequences of human trafficking. However, as shown by the sociological study conducted by the author, in the prevention of human trafficking, the majority of respondents do not consider the activities of educational institutions effective and sufficiently effective. Therefore, the curricula of general education and higher educational institutions should include training courses that will provide young people with information regarding legal and illegal migration, human rights, gender issues, and the dangers associated with THB. Together with all interested state and public structures, educational institutions should support efforts aimed at raising awareness of the most vulnerable groups of the population about the consequences and risks associated with human trafficking. Awareness-raising activities will lead to an increase in the number of citizens who will be confident that they are insured against situations related to human trafficking.
Home hazard modification programs for reducing falls in older adults: a systematic review and meta-analysis
Authors: Lektip Charupa , Chaovalit Sirawee , Wattanapisit Apichai , Lapmanee Sarawut , Nawarat Jiraphat , Yaemrattanakul Weeranan
Published: July 2023

Objective

This study aims to assess the effect of home modification in preventing falls in older adults.

Methods

A systematic review and meta-analysis of randomized studies were performed. The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered prospectively. Five electronic databases were systematically searched for related articles. The titles and abstracts of the articles found using the key search phrases—home modification and falling—were screened using inclusion and exclusion criteria. The Cochrane risk of bias tool was used to evaluate the studies’ methodology.

Results

A total of 12 trials were included. A meta-analysis was conducted using 10 studies with n = 1, 960 participants showing a clinically meaningful 7% reduction in falls (risk ratio = 0.93; 0.87–1).

Conclusions

Falls can be significantly reduced with the use of home modification interventions that are thorough, well-focused, have an environmental-fit perspective, and have adequate follow-up.
Scattered Painful Papulonodules in an Older Woman
Authors: Kim-Lim Penelope , Thomas Cristina
Published: July 2023

A 56-year-old woman was admitted for myeloablative conditioning in preparation for allogeneic hematopoietic cell transplant. Her course was complicated by severe mucositis, acute kidney injury, and neutropenic fever. During her admission, she also developed painful necrotic skin lesions, a nonproductive cough, and altered mental status. What is your diagnosis?
Engineering Cardiac Tissue for Advanced Heart‐On‐A‐Chip Platforms
Authors: Chen Xinyi , Liu Sitian , Han Mingying , Long Meng , Li Ting , Hu Lanlan , Wang Ling , Huang Wenhua , Wu Yaobin
Published: July 2023

Cardiovascular disease is a major cause of mortality worldwide, and current preclinical models including traditional animal models and 2D cell culture models have limitations in replicating human native heart physiology and response to drugs. Heart‐on‐a‐chip (HoC) technology offers a promising solution by combining the advantages of cardiac tissue engineering and microfluidics to create in vitro 3D cardiac models, which can mimic key aspects of human microphysiological systems and provide controllable microenvironments. Herein, recent advances in HoC technologies are introduced, including engineered cardiac microtissue construction in vitro, microfluidic chip fabrication, microenvironmental stimulation, and real‐time feedback systems. The development of cardiac tissue engineering methods is focused for 3D microtissue preparation, advanced strategies for HoC fabrication, and current applications of these platforms. Major challenges in HoC fabrication are discussed and the perspective on the potential for these platforms is provided to advance research and clinical applications.
Asymmetry During Fast Stretching of a Liquid Bridge
Authors: Asghar Muhammad Hassan , Brockmann Philipp , Dong Xulan , Niethammer Matthias , Maric Tomislav , Roisman Ilia , Bothe Dieter
Published: July 2023

The dynamics of an axisymmetric liquid bridge stretch are investigated by means of numerical simulations, and the results are validated experimentally. The constant acceleration of the lower substrate stretches the liquid bridge. A simplified simulation model of the experimental setup is developed for the unstructured volume‐of‐fluid two‐phase flow simulation method, which models the lower substrate as a fluid with a prescribed constant acceleration of the retracting substrate. The effect of stretching acceleration, fluid properties, and liquid volume on the liquid bridge dynamics is investigated. It is shown that at low acceleration the length of the lower portion of the bridge is greater than the upper portion, which is reversed at high acceleration. With increasing viscosity, this effect is decreased and the bridge becomes more symmetric.
Short‐term and long‐term effects of cryoballoon ablation versus antiarrhythmic drug therapy as first‐line treatment for paroxysmal atrial fibrillation: A systematic review and meta‐analysis
Authors: Liu Zirui , Yang Zhengkai , Lu Yu , Wang Haocheng , Zou Cao
Published: July 2023

Cryoballoon ablation (CBA) is an effective treatment for drug‐refractory atrial fibrillation (AF) patients. Whether CBA as a first‐line treatment is superior in the rhythm control of AF than antiarrhythmic drugs (AAD) remains unclear. CBA is superior to AAD as initial therapy for rhythm control of paroxysmal atrial fibrillation (PAF). A comprehensive database search was performed in PubMed, Embase, Cochrane, and Web of Science from inception to March 22, 2023. Treatment efficacy was pooled using risk ratio (RR) and standardized mean difference (SMD) with a 95% confidence interval (CI). This study was registered with Prospero (CRD42023401596). Five randomized‐controlled trials involving 923 patients and an observational study were included in this study. The CBA group had a significantly lower overall recurrence rate than the AAD group (CBA vs. AAD: RR = 0.59, 95% CI = 0.49–0.71, p < .05, I2 = 0). The incidence of persistent AF could be better controlled in the CBA group than in the AAD (CBA vs. AAD: RR = 0.17, 95% CI = 0.06–0.49, p < .05, I2 = 0). CBA could improve the quality of life (QoL) of patients better than AAD (CBA vs. AAD: SMD = 0.40, 95% CI = 0.14–0.67, p < .05, I2 = 68.5%). CBA can reduce hospitalization rate significantly than AAD at 36‐month follow‐up (CBA vs. AAD: RR = 0.29, 95% CI = 0.15‐0.58, p < .05, I2 = 0%). Compared to AAD, CBA as first‐line therapy could reduce the recurrence rate of atrial arrhythmia and incidence of persistent AF and improve QoL in PAF patients with lower incidences of hospitalization.
Rarefaction and extrapolation with beta diversity under a framework of Hill numbers: The iNEXT.beta3D standardization
Authors: Chao Anne , Thorn Simon , Chiu Chun‐Huo , Moyes Faye , Hu Kai‐Hsiang , Chazdon Robin L. , Wu Jessie , Magnago Luiz Fernando S. , Dornelas Maria , Zelený David , Colwell Robert K. , Magurran Anne E.
Published: July 2023

Based on sampling data, we propose a rigorous standardization method to measure and compare beta diversity across datasets. Here beta diversity, which quantifies the extent of among‐assemblage differentiation, relies on Whittaker's original multiplicative decomposition scheme, but we use Hill numbers for any diversity order q ≥ 0. Richness‐based beta diversity (q = 0) quantifies the extent of species identity shift, whereas abundance‐based (q > 0) beta diversity also quantifies the extent of difference among assemblages in species abundance. We adopt and define the assumptions of a statistical sampling model as the foundation for our approach, treating sampling data as a representative sample taken from an assemblage. The approach makes a clear distinction between the theoretical assemblage level (unknown properties/parameters of the assemblage) and the sampling data level (empirical/observed statistics computed from data). At the assemblage level, beta diversity for N assemblages reflects the interacting effect of the species abundance distribution and spatial/temporal aggregation of individuals in the assemblage. Under independent sampling, observed beta (= gamma/alpha) diversity depends not only on among‐assemblage differentiation but also on sampling effort/completeness, which in turn induces dependence of beta on alpha and gamma diversity. How to remove the dependence of richness‐based beta diversity on its gamma component (species pool) has been intensely debated. Our approach is to standardize gamma and alpha based on sample coverage (an objective measure of sample completeness). For a single assemblage, the iNEXT method was developed, through interpolation (rarefaction) and extrapolation with Hill numbers, to standardize samples by sampling effort/completeness. Here we adapt the iNEXT standardization to alpha and gamma diversity, that is, alpha and gamma diversity are both assessed at the same level of sample coverage, to formulate standardized, coverage‐based beta diversity. This extension of iNEXT to beta diversity required the development of novel concepts and theories, including a formal proof and simulation‐based demonstration that the resulting standardized beta diversity removes the dependence of beta diversity on both gamma and alpha values, and thus reflects the pure among‐assemblage differentiation. The proposed standardization is illustrated with spatial, temporal, and spatiotemporal datasets, while the freeware iNEXT.beta3D facilitates all computations and graphics.
TiO2‐Based Hybrid Nanoscale Light Source
Authors: Guo Haomin , Hu Qi , Chen Zhifeng , Zhang Wei , Pan Shusheng , Zhang Chengyun
Published: July 2023

The titanium dioxide nanosphere (TiO2 NS) is a moderate refractive index (MRI) nanostructure which can support Mie resonances such as magnetic dipole resonance (MDR), electric dipole resonance (EDR), etc. However, TiO2 is a wide indirect band gap (3.2 eV) semiconductor, and TiO2 NSs cannot be excited to emit luminescence by near‐infrared (NIR, 770 nm–800 nm) femtosecond (fs) lasers. In this paper, a MDR‐induced nanoscale plasmon source is conceived to provide a large number of hot electrons, which can be used to light up TiO2 NSs. The effect of different metals (Titanium‐Ti, Palladium‐Pd, Gold‐Au) as the MDR‐induced nanoscale plasmon sources on the optical response of TiO2‐based hybrid NSs is studied. This work provides a new strategy for the application of TiO2‐based hybrid NSs as integrated efficient nanoscale white light sources.
Iron and Copper Catalysts Derived from Inorganic Waste for Dye Degradation
Authors: Gogoi Gautam , Saikia Sayanika , Das Abhijit , Saikia Simashree , Hoque Nazimul , Biswas Subir , Dey Mrityunjoy , Kalita Pabitra Kumar , Bania Kusum K.
Published: July 2023

Dyes like methyl violet (MV) and methyl orange (MO) released from textile industries are considered to be water pollutants. Likewise metal waste from electronic devices and from metallurgical industries are causing harmful effects. Therefore, looking into the negative impact of such waste materials herein copper oxide (CuO) and iron oxide (Fe3O4) photocatalysts were prepared from electronic and candle waste, respectively materials. The metal oxides were supported on a graphitic carbon matrix obtained from waste tea leaves. The synthesized materials were well characterized using different analytical techniques. The carbon‐supported CuO and Fe3O4 catalysts exhibited good photocatalytic activity under UV‐light irradiation in the photo‐degradation of coloured dyes like methyl orange (MO) and methyl violet (MV). The copper (Cu)‐catalyst with band gap like that of titanium dioxide (TiO2) showed superior activity over the iron (Fe)‐catalyst under identical conditions. Cu‐catalyst was found to degrade the dyes within 10–15 min while it took longer time with Fe‐catalyst up to 50 min. The measure of total organic content (TOC) after the dye‐degradation study implied that Cu‐catalyst can carbonize MV upto 89.6 % within 15 min while the same was found to be less (79.5 %) for MO. The ability of the synthesized photocatalysts from waste materials in dye degradation was monitored through FTIR analysis. The mechanistic study suggested the involvement of both the holes and free radicals in the photo‐oxidation of dye components.
Large-scale lipidomics profiling reveals characteristic lipid signatures associated with an increased cardiovascular risk
Authors: Harm Tobias , Dittrich Kristina , Brun Adrian , Fu Xiaoqing , Frey Moritz , Petersen Uribe Alvaro , Schwarz Frederic-Joaquim , Rohlfing Anne-Katrin , Castor Tatsiana , Geisler Tobias , Rath Dominik , Lämmerhofer Michael , Gawaz Meinrad P.
Published: July 2023

Background and aims

Patients with cardiovascular disease (CVD) are at high risk to develop adverse events. The distinct risk of developing adverse cardiovascular (CV) events is not solely explained by traditional risk factors. Platelets are essentially involved in progression of CVD including coronary artery disease (CAD) and platelet hyperreactivity leads to development of adverse CV events. Alterations in the platelet lipidome lead to platelet hyperresponsiveness and thus might alter the individual risk profile. In this study, we investigate the platelet lipidome of CAD patients by untargeted lipidomics and elucidate alterations in the lipid composition of patients with adverse CV events.

Methods

We characterized the platelet lipidome in a large consecutive CAD cohort (n = 1057) by an untargeted lipidomics approach using liquid chromatography coupled to mass spectrometry.

Results

The platelet lipidome in this study identified 767 lipids and characteristic changes occurred in patients with adverse CV events. The most prominent upregulated lipids in patients with cardiovascular events primarily belong to the class of phospholipids and fatty acyls. Further, upregulated platelet lipids are associated with an increased cardiovascular or bleeding risk and independently associated with adverse events. In addition, alterations of the platelet lipidome are associated with modulation of in vitro platelet functions.

Conclusions

Our results reveal that the composition of the platelet lipidome is altered in CVD patients with an increased cardiovascular risk and distinct platelet lipids may indicate adverse events. Results of this study may contribute to improved risk discrimination and classification for cardiovascular events in patients with CVD.

Graphical abstract

Main findings of this study and hypothetical impact of altered platelet lipid signatures in patients with adverse cardiovascular events on platelet function and clinical outcome. LPE lysophosphatidylethanolamines, CAR acylcarnitines, FA fatty acids.
Exploring the Development of a Canadian Frostbite Care Network and the Future of Frostbite Care in Canada Using a Qualitative Approach
Authors: Klammer Lauren , Ollier Mary , Gauthier Josianne , Allen Lisa R. , Davidson Malcolm , Ahmed Yousuf , Smith-Turchyn Jenna , Hansen-Jaumard Delphine , Hebert Sebastien , Logsetty Sarvesh , Morris-Jantzen Dunavan , Peet Rachel , Poole Alex J. , Champion Caitlin
Published: July 2023

Introduction

The Canadian Frostbite Collaborative project is exploring frostbite patient care needs and current practices in Canada to inform the development of a Canadian frostbite care network (CFCN) as a national quality improvement initiative.

Methods

Using a quantitative and qualitative approach, this study aimed to define the landscape of current frostbite practices, challenges, and interest in future work.

Results

Current frostbite care practices were initially assessed through semistructured phone interviews of Canadian healthcare providers. Canadian healthcare providers managing frostbite in a range of health disciplines and contexts then participated in focus group sessions discussing the potential roles and opportunities as well as potential challenges in developing a CFCN. Roles and opportunities for a network in advancing frostbite care included facilitating research, educating stakeholders, facilitating collaboration, standardizing care, and advocating for frostbite care. Challenges identified in frostbite care and network development included managing resources, navigating the Canadian healthcare system, overcoming low numbers, and communicating with policymakers and frontline providers.

Conclusions

Formalizing a CFCN may provide important opportunities and support in overcoming critical barriers to providing high-quality frostbite care across Canada.
A Sticky Situation: Glue Migration during Hepatic Vein Embolization
Authors: Pal Koustav , Kuban Joshua D. , Murthy Ravi , Odisio Bruno C. , Metwalli Zeyad A.
Published: July 2023

The addition of hepatic venous embolization to portal venous embolization to achieve ipsilateral liver venous deprivation before major hepatectomy has been suggested to increase the extent of hypertrophy of the future liver remnant. The presented case discusses a hepatic vein embolization procedure complicated by the unintended migration of a glue cast used to achieve hepatic venous occlusion and subsequent management with endovascular retrieval of the glue cast from the inferior vena cava. The emerging role of hepatic venous embolization and associated complications are also discussed.