bluuebunny/crossref_metadata_2025 huggingface dataset:
Body Tactile Stimulation Reduces the Effects of High Stocking Density on the Welfare of Nile Tilapia (Oreochromis niloticus)
Authors: Gauy Ana Carolina dos Santos , Bolognesi Marcela Cesar , Gonçalves-de-Freitas Eliane
Published: June 2023

High stocking density is used in aquaculture to optimize farming. However, such strategies can stress territorial fish by increasing aggression, thus harming the fish welfare and productive performance. Here, we tested the effect of long-term tactile body stimulation (TS) on alleviating the impact of high stocking density in Nile tilapia (Oreochromis niloticus). Ten males were grouped for 21 days into four treatments (10 replicates each one) combining TS with high (1.2 kg·m³) or low (0.6 kg·m³) densities: (1) without TS and high density; (2) without TS and low density; (3) with TS and high density; and (4) with TS and low density. A rectangular PVC frame fitted with vertical plastic sticks sided with silicone bristles was placed in the center of aquarium. The fish receive TS when passing through the bristles. An apparatus without bristles was used as control. We found higher cortisol levels under TS conditions. All parameters of productive performance (growth, food efficiency, and condition factor) were higher in the treatment with TS and low density, lower in the treatment without TS and high density, and similar between treatments high density with TS and low density without TS. The results suggest that TS improves productive performance of Nile tilapia, counteracting the negative effects of high stocking density.
A Benchmark for Atlantic Salmon Conservation: Genetic Diversity and Structure in a Southern European Glacial Refuge before the Climate Changed
Authors: Almodóvar Ana , Nicola Graciela G. , Ayllón Daniel , Leal Sheila , Marchán Daniel F. , Elvira Benigno
Published: June 2023

Atlantic salmon Salmo salar supports highly valuable commercial and recreational fisheries in Europe, but its stocks are currently overexploited and threatened by climate change. Its southernmost populations (in northern Spain) play a key role in conserving the species’ original genetic diversity, which is endangered due to decades-long (1970s to 1990s) massive stocking with non-native stocks. Their decline is well documented, but the effect of stock transfer and conservation efforts is unclear. Nine microsatellite loci were amplified from archival samples (scales from 1958–1959) from eight Spanish rivers to analyse the species’ natural genetic dynamics before its decline started. Allelic richness was high in the historical populations (the 1950s) and above most contemporary estimates. Private alleles were found in most rivers, indicating high local uniqueness and relative isolation among river basins. Some alleles are regional markers since they are rare or absent from contemporary northern European populations. Effective population size suggested good conservation status, with higher values than those estimated for contemporary populations. Strong population structure and genetic differentiation between rivers were found, with limited gene flow, restricted to geographically close populations. Our estimates of historical genetic diversity and structure from southernmost salmon populations are a powerful benchmark to guide conservation programs.
Effect of the Freeze-Dried Mullein Flower Extract (Verbascum nigrum L.) Addition on Oxidative Stability and Antioxidant Activity of Selected Cold-Pressed Oils
Authors: Symoniuk Edyta , Marczak Zuzanna , Brzezińska Rita , Janowicz Monika , Ksibi Nour
Published: June 2023

The aim of the study was to analyze the influence of mullein flower extract addition on the oxidative stability and antioxidant activity of cold-pressed oils with a high content of unsaturated fatty acids. The conducted research has shown that the addition of mullein flower extract increases the oxidative stability of oils, but its addition depends on the type of oil and should be selected experimentally. In rapeseed and linseed oil, the best stability was found for samples with 60 mg of extract/kg of oil, while in chia seed oil and hemp oil, it was found with 20 and 15 mg of extract/kg of oil, respectively. The hemp oil exhibited the highest antioxidant properties, as evidenced by an increase in the induction time at 90 °C from 12.11 h to 14.05 h. Additionally, the extract demonstrated a protective factor of 1.16. Oils (rapeseed, chia seed, linseed, and hempseed) without and with the addition of mullein extract (2–200 mg of extract/kg of oil) were analyzed for oxidative stability, phenolic compounds content, and antioxidant activity using DPPH• and ABTS•+ radicals. After the addition of the extract, the oils had from 363.25 to 401.24 mg GAE/100 g for rapeseed oil and chia seed oil, respectively. The antioxidant activity of the oils after the addition of the extract ranged from 102.8 to 221.7 and from 324.9 to 888.8 µM Trolox/kg for the DPPH and ABTS methods, respectively. The kinetics parameters were calculated based on the oils’ oxidative stability results. The extract increased the activation energy (Ea) and decreased the constant oxidation rate (k).
Stability of Purple Corn Anthocyanin Encapsulated by Maltodextrin, and Its Combinations with Gum Arabic and Whey Protein Isolate
Authors: Deng Wei , Li Xiaoyi , Ren Guoqiu , Bu Qingmei , Ruan Yanye , Feng Ying , Li Bin
Published: June 2023

Purple corn anthocyanins are important natural colourants with cheap prices and rich bioactivities. However, their stability is limited. Microencapsulation is an effective way to improve anthocyanin stability and the influence of the type of wall material on the stability of encapsulated anthocyanin is very important. In this study, maltodextrin (MD) and its combination with whey protein isolate (WPI) or gum arabic (GA) were utilised as wall materials to obtain encapsulated purple corn anthocyanins (PCAs) (MD–PCA, MD–WPI–PCA, MD–GA–PCA) using spray drying. The effect of the amount of the wall material was determined by encapsulation efficiency, anthocyanin content, and colour. On this basis, the effects of the types of wall materials on the physicochemical characteristics, storage, and digestion stabilities of encapsulated PCA, as well as their stabilities in chewing tablets, were investigated. The highest encapsulation efficiency, suitable colour, and anthocyanin content were obtained with the mass ratios 1:1 PCA to MD, 2:3 PCA to MD–GA, and 1:1 PCA to MD–WPI. Microencapsulation increased PCA storage and digestion stabilities. All three types of PCA microcapsules had low water content and hygroscopicity and good water solubility. MD–PCA had the strongest stability when stored at 25 °C; MD–GA–PCA—when stored at 40 °C, or in the presence of 5000 Lux light illumination; MD–WPI–PCA—when stored in 75% relative humidity or during gastric–intestinal digestion, but its resistance to 40 °C temperature and light illumination was lower than those for the two others. When used in chewing tablets, MD encapsulation was most stable in the presence of Ca2+, VC, or Fe2+ and improved PCA digestion stability. In conclusion, MD is a good choice for PCA encapsulation in regular conditions. MD–GA and MD–WPI can be used when considering high storage temperature (or light illumination) and high humidity (or for high digestion stability), respectively. The results of this study provide a reference for the storage and application of PCA.
Microwave Spectroscopy Investigation of Carasau Bread Doughs: Effects of Composition up to 8.5 GHz
Authors: Macciò Claudia , Melis Andrea , Lodi Matteo Bruno , Garau Emanuele , Desogus Francesco , Loddo Antonio , Di Napoli Fabrizio , Mazzarella Giuseppe , Fanti Alessandro
Published: June 2023

Carasau bread is a flat bread, typical of Sardinia (Italy). The market of this food product has a large growth potential, and its industry is experiencing a revolution, characterized by digitalization and automation. To monitor the quality of this food product at different manufacturing stages, microwave sensors and devices could be a cost-effective solution. In this framework, knowledge of the microwave response of Carasau dough is required. Thus far, the analysis of the microwave response of Carasau doughs through dielectric spectroscopy has been limited to the dynamics of fermentation. In this work, we aim to perform complex dielectric permittivity measurements up to 8.5 GHz, investigating and modeling the role of water amount, salt and yeast concentrations on the spectra of this food product. A third-order Cole–Cole model was used to interpret the microwave response of the different samples, resulting in a maximum error of 1.58% and 1.60% for the real and imaginary parts of permittivity, respectively. Thermogravimetric analysis was also performed to support the microwave spectroscopy investigation. We found that dielectric properties of Carasau bread doughs strongly depend on the water content. The analysis highlighted that an increase in water quantity tends to increase the bounded water fraction at the expense of the free water fraction. In particular, the free water amount in the dough is not related to the broadening parameter γ2 of the second pole, whereas the bound water weight fraction is more evident in the γ2 and σdc parameters. An increase in electrical conductivity was observed for increasing water content. The microwave spectrum of the real part of the complex permittivity is slightly affected by composition, while large variation in the imaginary part of the complex dielectric permittivity can be identified, especially for frequencies below 4 GHz. The methodology and data proposed and reported in this work can be used to design a microwave sensor for retrieving the composition of Carasau bread doughs through their dielectric signature.
Some Properties of Interval Shapley Values: An Axiomatic Analysis
Authors: Ishihara Shinichi , Shino Junnosuke
Published: June 2023

Interval games are an extension of cooperative coalitional games, in which players are assumed to face payoff uncertainty. Characteristic functions thus assign a closed interval instead of a real number. This study revisits two interval game versions of Shapley values (i.e., the interval Shapley value and the interval Shapley-like value) and characterizes them using an axiomatic approach. For the interval Shapley value, we show that the existing axiomatization can be generalized to a wider subclass of interval games called size monotonic games. For the interval Shapley-like value, we show that a standard axiomatization using Young’s strong monotonicity holds on the whole class of interval games.
Vertical Structure of the Milky Way Disk with Gaia DR3
Authors: Vieira Katherine , Korchagin Vladimir , Carraro Giovanni , Lutsenko Artem
Published: June 2023

Using a complete sample of about 330,000 dwarf stars, well measured by Gaia DR3, limited to the galactic north and south solid angles |b|<75° and up to a vertical distance of 2 kpc, we analyze the vertical structure of the Milky Way stellar disks, based on projected tangential velocities. From selected subsamples dominated by their corresponding population, we obtain the thin and thick disk scale heights as hZ=279.76±12.49 pc and HZ=797.23±12.34 pc, respectively. Then from the simultaneous fitting of the sum of two populations over the whole sample, assuming these scale heights, we estimate the thick-to-thin disk number density ratio at the galactic plane to be ρT/ρt=0.750±0.049, which is consistent with a previous result by the authors: in the galactic plane there is a significant number of thick disk stars, possibly as many as thin disk ones, which also points to the existence of more thick disk stars than generally thought. The overall fit does not closely follow the data for |Z|>700 pc and points to the presence of more stars beyond the thin disk that cannot be accounted for by the two-disk model.
Clinical and Laboratory Manifestation of Gastrointestinal Involvement in MIS-C: A Single-Center Observational Study
Authors: Lazova Snezhina , Tomov Latchezar , Miteva Dimitrina , Tzotcheva Iren , Priftis Stamatios , Velikova Tsvetelina
Published: June 2023

Background: Digestive symptoms and gastrointestinal issues in children with coronavirus 2019 disease (COVID-19) and Multisystem Inflammatory Syndrome in Children (MIS-C) are commonly reported in pediatric studies from different countries. Our retrospective observational study aimed to summarize the main digestive symptoms and objective data on gastrointestinal involvement in children with MIS-C. Methods: We present the clinical, laboratory, and imaging data of 51 children with MIS-C hospitalized in a single center from 25 November 2020 to 24 April 2021, focusing on gastrointestinal involvement. Results: A total of 46/51 children (90.2%) reported at least one abdominal symptom (abdominal pain (86%, N = 44), vomiting, nausea, diarrhea), predominantly at presentation. Most children were older than 5 years (N = 40, 78%), predominated by the male sex (N = 37, 72.5%), and with a mean age of 8.82 ± 4.16 years. We found a tendency for lymphopenia, neutrophilia, and higher levels of CRP, d-dimer, and ferritin in MIS-C patients with abdominal pain (R-squared 0.188, F-statistic vs. constant model: 11.9, p-value = 0.00122, 20% explanation of variation with p = 0.001). We found a statistically significant linear relationship (regression) between neutrophile percentage (NEU%) and hospital stay and a tendency for elevated transaminases to be more frequent in older children (27.3% under 5 years and 65% over 5 years; p = 0.0583). We found no significant associations between digestive symptoms and age or the predominant SARS-CoV-2 variant. Conclusions: Most of our MIS-C patients presented with abdominal pain, usually along with other GI symptoms, which could be applied in clinical practice to MIS-C in children visiting the emergency room with abdominal pain and evidence of recent COVID-19 contact or infection. Further information from larger cohorts of MIS-C patients is needed to better understand the epidemiology of gastrointestinal involvement in these patients.
Propranolol-Loaded Limonene-Based Microemulsion Thermo-Responsive Mucoadhesive Nasal Nanogel: Design, In Vitro Assessment, Ex Vivo Permeation, and Brain Biodistribution
Authors: Abla Kawthar K. , Domiati Souraya , El Majzoub Rania , Mehanna Mohammed M.
Published: June 2023

Propranolol is the first-line drug for managing migraine attacks. D-limonene is a citrus oil known for its neuroprotective mechanism. Thus, the current work aims to design a thermo-responsive intranasal limonene-based microemulsion mucoadhesive nanogel to improve propranolol efficacy. Microemulsion was fabricated using limonene and Gelucire® as the oily phase, Labrasol®, Labrafil®, and deionized water as the aqueous phase, and was characterized regarding its physicochemical features. The microemulsion was loaded in thermo-responsive nanogel and evaluated regarding its physical and chemical properties, in vitro release, and ex vivo permeability through sheep nasal tissues. Its safety profile was assessed via histopathological examination, and its capability to deliver propranolol effectively to rats’ brains was examined using brain biodistribution analysis. Limonene-based microemulsion was of 133.7 ± 0.513 nm diametric size with unimodal size distribution and spheroidal shape. The nanogel showed ideal characteristics with good mucoadhesive properties and in vitro controlled release with 1.43-fold enhancement in ex vivo nasal permeability compared with the control gel. Furthermore, it displayed a safe profile as elucidated by the nasal histopathological features. The nanogel was able to improve propranolol brain availability with Cmax 970.3 ± 43.94 ng/g significantly higher than the control group (277.7 ± 29.71 ng/g) and with 382.4 % relative central availability, which confirms its potential for migraine management.
A Comprehensive Pan-Cancer Analysis of the Potential Biological Functions and Prognosis Values of RICTOR
Authors: Sun Ying , Li Rui , Nong Baoting , Songyang Zhou , Wang Xianren , Ma Wenbin , Zhou Qin
Published: June 2023

The importance of the network defined by phosphatidylinositol-3-kinase (PI3K), AKT and mammalian target of rapamycin (mTOR) downstream of Receptor Tyrosine Kinase (RTK) has been recognized for many years. However, the central role of RICTOR (rapamycin-insensitive companion of mTOR) in this pathway has only recently come to light. The function of RICTOR in pan-cancer still needs to be systematically elucidated. In this study, we examined RICTOR’s molecular characteristics and clinical prognostic value by pan-cancer analysis. Our findings indicate that RICTOR was overexpressed in twelve cancer types, and a high RICTOR expression was linked to poor overall survival. Moreover, the CRISPR Achilles’ knockout analysis revealed that RICTOR was a critical gene for the survival of many tumor cells. Function analysis revealed that RICTOR-related genes were mainly involved in TOR signaling and cell growth. We further demonstrated that the RICTOR expression was significantly influenced by genetic alteration and DNA-methylation in multiple cancer types. Additionally, we found a positive relationship between RICTOR expression and the immune infiltration of macrophages and cancer-associated fibroblasts in Colon adenocarcinoma and Head and Neck squamous cell carcinoma. Finally, we validated the ability of RICTOR in sustaining tumor growth and invasion in the Hela cell line using cell-cycle analysis, the cell proliferation assay, and wound-healing assay. Our pan-cancer analysis highlights the critical role of RICTOR in tumor progression and its potential as a prognostic marker for various cancer types.
What Drives the Contemporary Black–White Racial Disparities in Gout in the US? Impact of Social Determinants of Health
Authors: McCormick Natalie , Yokose Chio , Choi Hyon K.
Published: June 2023

Together with the substantial role of genetic factors, serum urate levels and the occurrence of gout are also heavily driven by environmental and clinical factors, including adiposity, dietary patterns, alcohol, kidney function, and diuretic medication use. These are, in turn, greatly influenced by the social determinants of health, which encompass access to health care, availability of healthy foods, and opportunities for physical activity but also education, income, social norms, and racism, among other forces. Gout-related health disparities have been described for Māori and Pacific people in New Zealand, but racial disparities in gout prevalence and outcomes between Black and White Americans have been under-recognised, and particularly, sex-specific data are scarce. In this article we review evidence from prior cohort studies and contemporary national-level data which show the incidence and prevalence of gout and hyperuricemia in Black adults in the US have come to exceed that in White adults and are disproportionately greater in Black women. Importantly, this emerging disparity can be attributed entirely to social determinants of health, including higher levels of adiposity and poverty in Black women compared to White women and lower kidney function and poorer quality diet among Black men compared to White men. Furthermore, Black patients with gout have received poorer quality gout-related care and experienced higher levels of healthcare use, especially Black women. While identifying targets for culturally safe interventions for addressing risk factor disparities is essential, evidence gaps remain about potential disparities in longer-term outcomes of gout, including cardio-metabolic-kidney endpoints and premature mortality. Sociodemographically diverse, population-based longitudinal cohort studies, research on implementation strategies for improved gout care delivery models for underserved groups, and efforts to minimise structural racism and its effects are key to achieving health equity in gout.
Role of the Nephrologist in Non-Kidney Solid Organ Transplant (NKSOT)
Authors: Viejo-Boyano Iris , López-Romero Luis Carlos , D’Marco Luis , Checa-Ros Ana , Peris-Fernández María , Garrigós-Almerich Enrique , Ramos-Tomás María Carmen , Peris-Domingo Ana , Hernández-Jaras Julio
Published: June 2023

Background: Chronic kidney disease (CKD) is a common complication of a non-kidney solid organ transplant (NKSOT). Identifying predisposing factors is crucial for an early approach and correct referral to nephrology. Methods: This is a single-center retrospective observational study of a cohort of CKD patients under follow-up in the Nephrology Department between 2010 to 2020. Statistical analysis was performed between all the risk factors and four dependent variables: end-stage renal disease (ESKD); increased serum creatinine ≥50%; renal replacement therapy (RRT); and death in the pre-transplant, peri-transplant, and post-transplant periods. Results: 74 patients were studied (7 heart transplants, 34 liver transplants, and 33 lung transplants). Patients who were not followed-up by a nephrologist in the pre-transplant (p < 0.027) or peri-transplant (p < 0.046) periods and those who had the longest time until an outpatient clinic follow-up (HR 1.032) were associated with a higher risk of creatinine increase ≥50%. Receiving a lung transplant conferred a higher risk than a liver or heart transplant for developing a creatinine increase ≥50% and ESKD. Peri-transplant mechanical ventilation, peri-transplant and post-transplant anticalcineurin overdose, nephrotoxicity, and the number of hospital admissions were significantly associated with a creatinine increase ≥50% and developing ESKD. Conclusions: Early and close follow-up by a nephrologist was associated with a decrease in the worsening of renal function.
The Effect of Health Status on Urban Adaptation of the Rural Elderly after Migration
Authors: Wang Kangkang , Li Min , Lyu Jie
Published: June 2023

As urbanization accelerates in China, more and more rural elders are moving to cities to live with their children. However, they face challenges in overcoming cultural, social, and economic disparities and maintaining health in urban life, and health is important human capital that may have a significant impact on the urban adaptation of rural elderly migrants (REMs). Based on the 2018 China Health and Retirement Longitudinal Study (CHARLS), this paper constructs an indicator system to measure the level of urban adaptation of REMs. The health level and urban adaptation of REMs are studied in depth, and how to better help them adapt to urban life in order to provide a healthy living environment and a good lifestyle is explored. The empirical analysis finds the following: (1) good health helps REMs achieve a better level of urban adaptation. (2) REMs with good health status are more likely to go to community clubs for activities and do physical activities and thus improve their urban adaptation level. (3) There are significant differences in the effects of health status on urban adaptation among REMs with different characteristics. REMs with better health status in the central and western regions have significantly higher levels of urban adaptation than those in the eastern regions, and men have higher levels of urban adaptation than women. Therefore, the government should construct classification measures according to the differentiated characteristics of rural elderly migrants’ urban adaptation, and guide and support their stratified and orderly adaptation to urban society.
Capturing Semantic Relationships in Electronic Health Records Using Knowledge Graphs: An Implementation Using MIMIC III Dataset and GraphDB
Authors: Aldughayfiq Bader , Ashfaq Farzeen , Jhanjhi N. Z. , Humayun Mamoona
Published: June 2023

Electronic health records (EHRs) are an increasingly important source of information for healthcare professionals and researchers. However, EHRs are often fragmented, unstructured, and difficult to analyze due to the heterogeneity of the data sources and the sheer volume of information. Knowledge graphs have emerged as a powerful tool for capturing and representing complex relationships within large datasets. In this study, we explore the use of knowledge graphs to capture and represent complex relationships within EHRs. Specifically, we address the following research question: Can a knowledge graph created using the MIMIC III dataset and GraphDB effectively capture semantic relationships within EHRs and enable more efficient and accurate data analysis? We map the MIMIC III dataset to an ontology using text refinement and Protege; then, we create a knowledge graph using GraphDB and use SPARQL queries to retrieve and analyze information from the graph. Our results demonstrate that knowledge graphs can effectively capture semantic relationships within EHRs, enabling more efficient and accurate data analysis. We provide examples of how our implementation can be used to analyze patient outcomes and identify potential risk factors. Our results demonstrate that knowledge graphs are an effective tool for capturing semantic relationships within EHRs, enabling a more efficient and accurate data analysis. Our implementation provides valuable insights into patient outcomes and potential risk factors, contributing to the growing body of literature on the use of knowledge graphs in healthcare. In particular, our study highlights the potential of knowledge graphs to support decision-making and improve patient outcomes by enabling a more comprehensive and holistic analysis of EHR data. Overall, our research contributes to a better understanding of the value of knowledge graphs in healthcare and lays the foundation for further research in this area.
South Korean Nurses’ Experiences of Speaking up for Patient Safety and Incident Prevention
Authors: Jeong Jeong Hee , Kim Sam Sook
Published: June 2023

Despite the importance of speaking up for patient safety, hesitancy to do so remains a major contributing factor to communication failure. This study aimed to investigate the experiences of South Korean nurses in speaking up to prevent patient safety incidents. Twelve nurses responsible for patient safety tasks or with experience in patient safety education were recruited from five hospitals (three university hospitals, two general hospitals) in city “B”. Data were collected through open-ended questions and in-depth interviews, transcribed, and analyzed using the inductive content analysis method. The study resulted in the identification of four main categories and nine subcategories that captured commonalities among the experience of the 12 nurses. The four main categories were as follows: the current scenario of speaking up, barriers to speaking up, strategies for speaking, and confidence training. There is a scarcity of research on speaking-up experiences for patient safety among nurses in South Korean. Overall, it is necessary to overcome cultural barriers and establish an environment that encourages speaking up. In addition, developing speaking-up training programs for nursing students and novice nurses is imperative to prevent patient safety incidents.
Individual Learning Needs of Japanese Public Health Dietitians by Years of Experience in Health Promotion
Authors: Kushida Osamu , Iida Ayaka , Arai Yusuke , Koyama Tatsuya , Tanaka Kazumi , Morooka Ayumi , Isobe Sumie , Okamoto Rie , Yoshita Katsushi
Published: June 2023

Lifelong education for dietitians in Japan is based mainly on competencies according to years of experience. Because learning content differs depending on the desired position and specialty, training programs that reflect the individual learning needs of public health dietitians are needed. This study aimed to assess the individual learning needs of public health dietitians via years of experience in health promotion. In 2021, an online survey of public health dietitians involved in health promotion in prefectures, designated cities, and other municipalities throughout Japan was conducted. Years of experience in health promotion were categorized as early (<10 years), mid-career (10–19 years), and leadership (≥20 years) periods. To ascertain individual learning needs, the survey asked about respondents’ desired final position, career path, and skills they felt they needed to improve in the future. Of the 1649 public health dietitians analyzed, all administrative categories preferred to work as public health generalists in mid-career or leadership periods rather than in the early period. In municipalities, more public health dietitians across all experience categories selected “professional competence”, such as knowledge in specialized areas and nutritional guidance techniques. It was suggested that public health dietitians in the mid-career and leadership periods have individual learning needs, in both nutrition specialists and public health generalists.
Knowledge and Attitudes toward Human Papillomavirus and Vaccination: A Survey among Nursing Students in Saudi Arabia
Authors: Abdelaliem Sally Mohammed Farghaly , Kuaia Abeer Mohammed , Hadadi Afnan Ahmed , Alhujayri Alhanouf Khalid , Al Anazi Amal Awad , Hajar Areen Abdulelah , AlShareda Ruba Shayaa , Amri Saleha Mohammed
Published: June 2023

Introduction: One of the most prevalent conditions affecting the vaginal organs is the human papilloma virus (HPV). Human papillomavirus (HPV) knowledge and attitudes have been the subject of numerous studies in Saudi Arabia. However, there are only a few studies that have examined university students’ attitudes and knowledge of the human papillomavirus and the vaccine that is associated with it. Aim: To predict the level of knowledge and attitudes regarding HPV and its related vaccine among undergraduate nursing students. Methodology: This was descriptive cross-sectional research. After being selected from Princess Nourah bint Abdulrahman University’s College of Nursing, 307 nursing students agreed to take part and completed an online survey that was self-administered. Results: The majority of the participants (73.5%) had a low level of knowledge of HPV with a mean score of 2.77 ± 1.78. In addition, more than half of the participating nursing students (57%) had a moderate attitude toward HPV vaccination with a mean score of 51.18 ± 11.16. The study results also verified that there was a highly significant correlation between the nursing students’ demographics and their knowledge and attitudes toward HPV (p < 0.001). According to the SEM, nursing students’ knowledge regarding HPV accounted for 48% of the variance in students’ attitudes. Conclusion: Nursing students’ knowledge regarding HPV vaccination is an important predictor of students’ attitudes regarding HPV.
Relationships between Health Education, Health Behaviors, and Health Status among Migrants in China: A Cross-Sectional Study Based on the China Migrant Dynamic Survey
Authors: Kim Minji , Gu Hai
Published: June 2023

Managing the health of migrants has become a crucial aspect of promoting social harmony and cohesion in China. This study investigates the impact of public health education on the health status of migrants in China using cross-sectional data from the China Migrants Dynamic Survey 2017. A total of 169,989 migrants in China were selected as samples for empirical test. Data were analyzed using descriptive statistics, logistic regression, and the structural equation model. The findings show that health education significantly influences the health status of migrants in China. Specifically, health education related to occupational diseases, venereal diseases/AIDS, and self-rescue in public emergencies had a significant positive impact on migrants’ health, while health education regarding chronic diseases had a significant negative impact. Health education delivered through lectures and bulletin boards had a significant positive impact on migrants’ health, but online education had a significant negative effect on the health status of migrants. The effects of health education differ by gender and age, with a stronger positive impact on female migrants and elderly migrants aged 60 and above. The mediating effect of health behaviors was significant only in the total effect. In conclusion, health education can effectively enhance the health status of migrants in China by modifying their health behaviors.
Study Protocol for the Evaluation of Multidisciplinary Medication Reconciliation Service in Adult Patients Undergoing Thoracic and Cardiovascular Surgery (The MERITS Study): A Single-Center Controlled before-and-after Study
Authors: Park Soyoung , Kim A Jeong , Chae Hyun-Woo , Heo Kyu-Nam , Kim Yookyung , Kim Sung Hwan , Cho Yoon Sook , Lee Hyun Joo , Lee Ju-Yeun
Published: June 2023

Medication reconciliation (MR), which is widely implemented worldwide, aims to improve patient safety to reduce the medication errors during care transition. Despite its widespread use, MR has not yet been implemented in the Republic of Korea, and its effectiveness has not been studied. We aimed to evaluate the impact of a multidisciplinary MR service in older patients undergoing thoracic and cardiovascular surgery. This is a single-center, prospective, controlled, before-and-after study of adult patients taking at least one chronic oral medication. Depending on the period of each patient’s participation, they will be allocated to an intervention group or control group. Patients in the intervention group will receive multidisciplinary MR, and those in the control group will receive usual care. The primary outcome is to assess the impact of the MR service on medication discrepancies between the best possible medication history and medication orders at care transition. Secondary outcomes include the incidence rate of medication discrepancies at each transition, the discrepancy rate between the sources of information, the impact of MR on medication appropriateness index score, drug-related problems, 30-day mortality, the emergency department visit rate, readmission rate after discharge, the rate and acceptability of pharmacists’ intervention during hospitalization, and patients’ satisfaction.
Towards the Provision of Palliative Care Services in the Intensive Coronary Care Units: Nurses’ Knowledge, Training Needs, and Related-Barriers
Authors: Abu-Aziz Baraa , Alkasseh Areefa S. M. , Bayuo Jonathan , Abu-Odah Hammoda
Published: June 2023

Despite the notable benefits of palliative care (PC) for patients with chronic diseases, its delivery to people with cardiac problems, particularly in the Middle East region (EMR), remains a critical issue. There is a scarcity of research assessing nursing staff’s needs and knowledge in providing PC to cardiac patients in the EMR. This study aimed to assess the level of knowledge and needs of PC among nurses towards the provision of PC in intensive coronary care units (ICCUs) in the Gaza Strip, Palestine. It also identified the barriers to the provision of PC services in ICCUs in the Gaza Strip. A hospital-based descriptive quantitative cross-sectional design was adopted to collect data from 85 nurses working in ICCUs at four main hospitals in the Gaza Strip. Knowledge about PC was collected using a developed questionnaire based on the Palliative Care Quiz Nursing Scale (PCQN) and Palliative Care Knowledge Test (PCKT). PC training needs and barriers were assessed using the PC Needs Assessment instrument. Approximately two-thirds of nurses did not receive any PC educational or training programs, which contributed to their lack of PC knowledge. Most nurses would like to enroll in PC training programs, such as family support and communications skills courses. Nurses reported that there was a high demand for PC guidelines and discharge planning for patients with chronic illnesses. Insufficient healthcare professionals’ knowledge about PC and a staff shortage were the main barriers to integrating PC into the Gaza healthcare system. This study suggests incorporating PC into nursing curricula and in-service training, and it covers both basic and advanced PC principles. Intensive coronary care unit nurses need knowledge and training about PC, guidance, and support to provide appropriate care to patients with cardiovascular issues.
Workers with Suspected Diagnosis of Silicosis: A Case Study of Sarcoidosis Versus Siderosis
Authors: Delgado-García Diemen , Miranda-Astorga Patricio , Delgado-Cano Ashley , Gómez-Salgado Juan , Ruiz-Frutos Carlos
Published: June 2023

Silicosis is one of the most important occupational respiratory diseases worldwide, hence the importance of making a correct diagnosis. Diagnosis is commonly based on radiological findings according to the ILO International Classification of Radiographs of Pneumoconioses and occupational exposure. High-resolution computed tomography is indicated for differential diagnosis. This article presents two cases with an initial diagnosis of silicosis that ended up being diagnosed as sarcoidosis and siderosis, respectively. The first case was a 42-year-old male who worked as a crushing operator in an underground copper and molybdenum mine for 22 years. He had a history of exposure to silicon dioxide and was asymptomatic. X-rays did not distinguish silicosis or siderosis, but histological findings (open lung biopsy) allowed for a diagnosis of sarcoidosis. The second case was a 50-year-old male who had worked as a welder in a molybdenum filter plant, an open pit mine since 2013; he spent the previous 20 years as a welder in an underground copper mine, with exposure to silicon dioxide and was symptomatic. The first radiograph showed opacities that were compatible with pulmonary silicosis. A subsequent high-resolution computed tomography and lung biopsy showed a pattern of pulmonary siderosis. Due to the similarities in the radiographs of these three diseases, greater emphasis must be placed on the differential diagnosis, for which a complete occupational and clinical history is important in order to provide clues for the performance of complementary tests to avoid misdiagnosing.
Preperitoneal Pelvic Packing versus Angioembolization for Patients with Hemodynamically Unstable Pelvic Fractures with Pelvic Bleeding: A Single-Centered Retrospective Study
Authors: Gong Seong Chan , Park Ji Eun , Kang Sooyeon , An Sanghyun , Kim Myoung Jun , Kim Kwangmin , Shin In Sik
Published: June 2023

The aim of this study was to compare the outcomes of preperitoneal pelvic packing (PPP) and angioembolization (AE) for patients with equivocal vital signs after initial resuscitation. This single-centered retrospective study included information from the database of a regional trauma center from April 2014 to December 2022 for patients with pelvic fractures with a systolic blood pressure of 80–100 mmHg after initial fluid resuscitation. The patients’ characteristics, outcomes, and details of AE after resuscitative endovascular balloon occlusion of the aorta (REBOA) placed in zone III were collected. The follow-up duration was from hospital admission to discharge. A total of 65 patients were enrolled in this study. Their mean age was 59.2 ± 18.1 years, and 40 were males. We divided the enrolled patients into PPP (n = 43) and AE (n = 22) groups. The median time from emergency department (ED) to procedure and the median duration of ED stay were significantly longer in the AE group than in the PPP group (p ≤ 0.001 for both). The median mechanical ventilation (MV) duration was significantly shorter (p = 0.046) in the AE group. The number of patients with complications, overall mortality, and mortality due to hemorrhage did not differ between the two groups. Three patients (13.6%) were successfully treated with AE after REBOA. AE may be beneficial for patients with hemodynamically unstable pelvic fractures who show equivocal vital signs after initial fluid resuscitation in terms of reducing the MV duration and incidence of infectious complications.
In Situ Study of the Painting “Hiroshima I” (1958) by Werner Tübke (1929–2004)
Authors: Smolianskaia Aleksandra A. , Andreev Ivan I. , Sirro Sergey V. , Aseev Vladimir A. , Tereschenko Elena Y. , Smolyanskaya Olga A.
Published: June 2023

This article presents the results of technical studies of the oil painting by the artist of German origin Werner Tübke “Hiroshima I” (1958). The creative heritage of this author has not been studied enough and represents scattered data on the technology of painting and artistic techniques. The aim of this work was to determine the art materials and painting technology described in his diaries, using the example of his only painting represented in Russia: “Hiroshima I”. For this purpose, an in situ approach was implemented using some simple museum instrumentations—UV-induced visible luminescence, infrared reflectography (IRR), radiography, portable X-ray fluorescence (XRF), Fourier transform Infrared spectroscopy (FT-IR), and polarizing microscopy using microprobes. As a result, the pigment composition of the painting layers could be determined, the painting technology refined, and a previously unknown hidden portrait of Werner Tübke’s father revealed.
Vibration Analysis of Pulse-Width-Modulated Nozzles in Vineyard Blast Sprayers
Authors: Ortiz Coral , Torregrosa Antonio , Saiz-Rubio Verónica , Rovira-Más Francisco
Published: June 2023

Spraying systems to protect crops against pests are still necessary to maintain food production at the rates demanded by the current population. However, today, it is crucial to use precision agriculture to reduce the negative effects of pesticides and other agrochemicals such as fungicides. In particular, pressure fluctuations related to transient states when using pulse-width-modulated nozzles (PMW) have been reported to decrease the accuracy of preset flow rates in air-assisted orchard sprayers. The objective of this paper is to analyze the vibrations induced in the spraying system of a vineyard blast sprayer controlled by pulse-width-modulated nozzles, considering the instantaneous duty cycle (DC) as the control variable. An air-assisted vineyard sprayer was modified to host 24 solenoid shutoff valves with hollow disc–cone nozzles. A triaxial accelerometer was mounted to track the effect of duty cycle (20%, 30%, 50%, and 70%). In addition to accelerations, high-speed images were recorded, and the pressure according to time and the flow were estimated. The hydraulic system of the sprayer, when controlled in real time by the PWM solenoids, created pulsating impacts at the nozzle level with the same frequency of 10 Hz of the PMW system. The impact effect was significantly higher for low duty cycles under 40% DC. In addition, to demonstrate the inaccuracy of opening and closing the valves at a precisely specified time, this study also confirmed the divergence between the theoretical duty cycles commanded by the sprayer’s control unit and the actual ones measured in real time. The results of the analysis showed the difficulty of opening and closing the valves with precision to obtain accurate duty cycles in the practical implementation of smart sprayers and the importance of understanding the vibration effects of pulses in arrangements of multiple PWM nozzles working simultaneously.
Bioefficacy of Lecanoric Acid Produced by Parmotrema austrosinense (Zahlbr.) Hale against Tea Fungal Pathogens
Authors: Rajendran Kalidoss , Ponmurugan Ponnusamy , Gnanamangai Balasubramanian Mythili , Karuppiah Ponmurugan , Shaik Mohammed Rafi , Khan Mujeeb , Khan Merajuddin , Shaik Baji
Published: June 2023

Lichens are symbiotic organisms that are composed of fungal partners and photosynthetic algal partners. During the symbiotic process in lichen thallus, the fungus synthesizes certain secondary metabolites in which lecanoric acid is very important in terms of antibiotic properties. Considering the vital importance of lecanoric acid, the present study aimed to produce lecanoric acid from the thallus of Parmotrema austrosinense lichen using Modified Bold’s basal salt medium and evaluate the bio-efficacy against tea fungal pathogens. Lecanoric acid was purified and confirmed by micro-crystallization method and subsequently bioassayed against tea fungal pathogens. The results revealed that lecanoric acid registered a significant antifungal activity in terms of the growth inhibition of test pathogens. Companion systemic and botanical fungicides were found to be inferior to lecanoric acid in the percentage of growth inhibition. The inhibition rate varied among tea pathogens. Of the tea pathogens tested, tea leaf disease-causing pathogens including Cercospora theae (C. theae), Glomerella cingulata (G. cingulate), and Phomopsis theae (P. theae) showed the highest percentage of growth inhibition followed by stem and root rot diseases. The present study suggests that lecanoric acid showed an inhibitory effect against tea pathogens, which might be due to antibiotic properties and fungicidal action of lecanoric acid.
Exclusive Breastfeeding at Discharge in Regional New South Wales, Australia: The Role of Antenatal Care (2011–2020)
Authors: Woolley Emma , Buck Gretchen , Jackson Jackie , Bowman Rebekah , Fox Louise , Gallagher Shirlena , Sorrell Malindey , Ghimire Pramesh Raj
Published: June 2023

Increasing the number of infants exclusively breastfeeding on discharge from the hospital after birth is a key goal of breastfeeding policy in New South Wales (NSW), Australia. Despite consistent efforts, exclusive breastfeeding on discharge rates have declined over the past decade. Using pooled data from the New South Wales Perinatal Data Collection from 2011 to 2020, we examined the association between antenatal care (ANC) and exclusive breastfeeding at discharge from birth admission outcomes for mother–baby dyads in Southern New South Wales Local Health District (SNSWLHD). Our study confirmed that exclusive breastfeeding rates in SNSWLHD have declined over the past decade, providing local evidence to support action. Late entry to ANC and a failure to attend the recommended number of ANC visits were important predictors of a lower rate of exclusive breastfeeding on discharge. Improving accessibility to ANC visits for rural and regional mothers has potential to positively impact breastfeeding rates in SNSWLHD. We suggest that wider implementation of caseload midwifery models may have a positive impact on breastfeeding outcomes in the region for all mother–baby dyads, but particularly for Aboriginal mothers and infants, younger mothers and mothers experiencing disadvantage.
Considerations on Electrochemical Technologies for Water Purification and Wastewater Treatment
Authors: Costa Josiel Martins
Published: June 2023

Water scarcity and pollution are global issues caused by factors, such as population growth, industrialization, and the utilization of water resources [...]
Effect of High-Density Polyethylene Microplastics on the Survival and Development of Eastern Oyster (Crassostrea virginica) Larvae
Authors: Bhatt Sulakshana , Fan Chunlei , Liu Ming , Wolfe-Bryant Brittany
Published: June 2023

Microplastic (MP) pollution is a growing global concern—especially in estuarine areas that serve as natural habitats and nurseries for many marine organisms. One such marine organism is the Eastern oyster (Crassostrea virginica), which is a reef-forming keystone species in the Chesapeake Bay, the largest estuary in the United States. To understand the potential impacts of MP pollution on the estuary ecosystem, the effects of high-density polyethylene (HDPE) MPs on Eastern oyster larval survival and development were investigated. Three cohorts of larvae were exposed to HDPE MPs with a size of 10–90 µm at a 10 mg/L concentration, after 7 to 11 days of fertilization. After exposure, the number and size of oyster larvae were measured twice a week for approximately 2 weeks until larval settlement. The experiment found that there were no significant differences in the rate of survival between the control and MP-addition treatments. However, we noticed that larval development was significantly delayed with the MP treatment. The percentage of larvae that were ready to settle was 64% with the control treatment compared to 43.5% with the MP treatment. This delay in growth resulted in a delayed larval settlement, which could adversely affect the survival of the Eastern oyster due to the increased risk of predation. The current study demonstrates that MPs could be a risk to the ecology of estuaries, and plastic pollution management is needed for the preservation of these estuaries.