bluuebunny/crossref_metadata_2025 huggingface dataset:
The Assessment of Residents’ Perception of Possible Benefits and Challenges of Home Vertical Gardens in Kigali, Rwanda
Authors: Tafahomi Rahman , Nkurunziza David , Benineza Gatoni Gwladys , Nadi Reihaneh , Dusingizumuremyi Regis
Published: May 2024

This paper aimed to provide a new insight into the application of home vertical gardens in Kigali, the capital of Rwanda, through a pre-assessment of the inhabitants’ perceptions. There are several studies that indicated the awareness of the way residents think about the potential benefits and challenges of home gardens could make a considerable difference in designing and implementing these gardens. The Likert-scaled questionnaire (n = 558) was employed to evaluate how residents perceive vertical gardens, and what issues concern them most. The findings revealed that dwellers are almost familiar with the vertical garden concept and its possible effects on urban environments. The respondents mostly regarded vertical gardens as nice spots to socialize, relax, and interact with nature, and an opportunity for beautification, and recreation by growing ornamental and edible plants. However, they were rather apprehensive about some issues, more importantly, the extra expenses, the complicated operation and maintenance, and the type of structure installed on walls. In conclusion, small-scale and low-cost vertical gardens with lightweight structures and easy-to-use technologies are more likely to encourage householders to embrace home gardens. It is recommended that the vertical garden projects should be integrated into the urban green network strategy, leading to facilitating the processes of decision-making and financing.
Application of Waste Tire in Construction: A Road towards Sustainability and Circular Economy
Authors: Hassan Mohammad R. , Rodrigue Denis
Published: May 2024

The global demand for rubber is on a steady rise, which is driven by the increasing production of automobiles and the growing need for industrial, medical, and household products. This surge in demand has led to a significant increase in rubber waste, posing a major global environmental challenge. End-of-life tire (ELT) is a primary source of rubber waste, having significant environmental hazards due to its massive stockpiles. While landfilling is a low-cost and easy-to-implement solution, it is now largely prohibited due to environmental concerns. Recently, ELT rubber waste has received considerable attention for its potential applications in civil engineering and construction. These applications not only enhance sustainability but also foster a circular economy between ELT rubber waste with the civil engineering and construction sectors. This review article presents a general overview of the recent research progress and challenges in the civil engineering applications of ELT rubber waste. It also discusses commercially available recycled rubber-based construction materials, their properties, testing standards, and certification. To the best of the authors’ knowledge, this is the first time such a discussion on commercial products has been presented, especially for civil engineering applications.
Global Generalized Mersenne Numbers: Definition, Decomposition, and Generalized Theorems
Authors: Pletser Vladimir
Published: May 2024

A new generalized definition of Mersenne numbers is proposed of the form an−a−1n, called global generalized Mersenne numbers and noted GMa,n with base a and exponent n positive integers. The properties are investigated for prime n and several theorems on Mersenne numbers regarding their congruence properties are generalized and demonstrated. It is found that for any a, GMa,n−1 is even and divisible by n, a and a−1 for any prime n>2, and by aa−1+1 for any prime n>5. The remaining factor is a function of triangular numbers of a−1, specific for each prime n. Four theorems on Mersenne numbers are generalized and four new theorems are demonstrated, showing first that GMa,n≡1or7mod12 depending on the congruence of amod4; second, that GMa,n−1 are divisible by 10 if n≡1mod4 and, if n≡3mod4, GMa,n≡1or7or9mod10, depending on the congruence of amod5; third, that all factors ci of GMa,n are of the form 2nfi+1 such that ci is either prime or the product of primes of the form 2nj+1, with fi,j natural integers; fourth, that for prime n>2, all GMa,n are periodically congruent to ±1or±3mod8 depending on the congruence of amod8; and fifth, that the factors of a composite GMa,n are of the form 2nfi+1 with fi≡umod4 with u=0, 1, 2 or 3 depending on the congruences of nmod4 and of amod8. The potential use of generalized Mersenne primes in cryptography is shortly addressed.
Deep Residual Network with a CBAM Mechanism for the Recognition of Symmetric and Asymmetric Human Activity Using Wearable Sensors
Authors: Mekruksavanich Sakorn , Jitpattanakul Anuchit
Published: May 2024

Wearable devices are paramount in health monitoring applications since they provide contextual information to identify and recognize human activities. Although sensor-based human activity recognition (HAR) has been thoroughly examined, prior studies have yet to definitively differentiate between symmetric and asymmetric motions. Determining these movement patterns might provide a more profound understanding of assessing physical activity. The main objective of this research is to investigate the use of wearable motion sensors and deep convolutional neural networks in the analysis of symmetric and asymmetric activities. This study provides a new approach for classifying symmetric and asymmetric motions using a deep residual network incorporating channel and spatial convolutional block attention modules (CBAMs). Two publicly accessible benchmark HAR datasets, which consist of inertial measurements obtained from wrist-worn sensors, are used to assess the model’s efficacy. The model we have presented is subjected to thorough examination and demonstrates exceptional accuracy on both datasets. The ablation experiment examination also demonstrates noteworthy contributions from the residual mappings and CBAMs. The significance of recognizing basic movement symmetries in increasing sensor-based activity identification utilizing wearable devices is shown by the enhanced accuracy and F1-score, especially in asymmetric activities. The technique under consideration can provide activity monitoring with enhanced accuracy and detail, offering prospective advantages in diverse domains like customized healthcare, fitness tracking, and rehabilitation progress evaluation.
Topological Deformations of Manifolds by Algebraic Compositions in Polynomial Rings
Authors: Bagchi Susmit
Published: May 2024

The interactions between topology and algebraic geometry expose various interesting properties. This paper proposes the deformations of topological n-manifolds over the automorphic polynomial ring maps and associated isomorphic imbedding of locally flat submanifolds within the n-manifolds. The manifold deformations include topologically homeomorphic bending of submanifolds at multiple directions under algebraic operations. This paper introduces the concept of a topological equivalence class of manifolds and the associated equivalent class of polynomials in a real ring. The concepts of algebraic compositions in a real polynomial ring and the resulting topological properties (homeomorphism, isomorphism and deformation) of manifolds under algebraic compositions are introduced. It is shown that a set of ideals in a polynomial ring generates manifolds retaining topological isomorphism under algebraic compositions. The numerical simulations are presented in this paper to illustrate the interplay of topological properties and the respective real algebraic sets generated by polynomials in a ring within affine 3-spaces. It is shown that the coefficients of polynomials generated by a periodic smooth function can induce mirror symmetry in manifolds. The proposed formulations do not consider the simplectic class of manifolds and associated quantizable deformations. However, the proposed formulations preserve the properties of Nash representations of real algebraic manifolds including Nash isomorphism.
High-Performance Liquid Chromatography–Fluorescence Detection Method for Ochratoxin A Quantification in Small Mice Sample Volumes: Versatile Application across Diverse Matrices Relevant for Neurodegeneration Research
Authors: Beraza Elba , Serrano-Civantos Maria , Izco Maria , Alvarez-Erviti Lydia , Gonzalez-Peñas Elena , Vettorazzi Ariane
Published: May 2024

Ochratoxin A (OTA) is a mycotoxin commonly found in various food products, which poses potential health risks to humans and animals. Recently, more attention has been directed towards its potential neurodegenerative effects. However, there are currently no fully validated HPLC analytical methods established for its quantification in mice, the primary animal model in this field, that include pivotal tissues in this area of research, such as the intestine and brain. To address this gap, we developed and validated a highly sensitive, rapid, and simple method using HPLC-FLD for OTA determination in mice tissues (kidney, liver, brain, and intestine) as well as plasma samples. The method was rigorously validated for selectivity, linearity, accuracy, precision, recovery, dilution integrity, carry-over effect, stability, and robustness, meeting the validation criteria outlined by FDA and EMA guidelines. Furthermore, the described method enables the quantification of OTA in each individual sample using minimal tissue mass while maintaining excellent recovery values. The applicability of the method was demonstrated in a repeated low-dose OTA study in Balb/c mice, which, together with the inclusion of relevant and less common tissues in the validation process, underscore its suitability for neurodegeneration-related research.
Probing the Propeller Regime with Symbiotic X-ray Binaries
Authors: Afonina Marina D. , Popov Sergei B.
Published: May 2024

At the moment, there are two neutron star X-ray binaries with massive red supergiants as donors. Recently, De et al. (2023) proposed that the system SWIFT J0850.8-4219 contains a neutron star at the propeller stage. We study this possibility by applying various models of propeller spin-down. We demonstrate that the duration of the propeller stage is very sensitive to the regime of rotational losses. Only in the case of a relatively slow propeller model proposed by Davies and Pringle in 1981, the duration of the propeller is long enough to provide a significant probability to observe the system at this stage. Future determination of the system parameters (orbital and spin periods, magnetic field of the compact object, etc.) will allow putting strong constraints on the propeller behavior.
Hepatitis B Virus Infection: A Mini Review
Authors: Asandem Diana Asema , Segbefia Selorm Philip , Kusi Kwadwo Asamoah , Bonney Joseph Humphrey Kofi
Published: May 2024

Hepatitis B and C viruses (HBV and HCV) are the leading causes of end-stage liver disease worldwide. Although there is a potent vaccine against HBV, many new infections are recorded annually, especially in poorly resourced places which have lax vaccination policies. Again, as HBV has no cure and chronic infection is lifelong, vaccines cannot help those already infected. Studies to thoroughly understand the HBV biology and pathogenesis are limited, leaving much yet to be understood about the genomic features and their role in establishing and maintaining infection. The current knowledge of the impact on disease progression and response to treatment, especially in hyperendemic regions, is inadequate. This calls for in-depth studies on viral biology, mainly for the purposes of coming up with better management strategies for infected people and more effective preventative measures for others. This information could also point us in the direction of a cure. Here, we discuss the progress made in understanding the genomic basis of viral activities leading to the complex interplay of the virus and the host, which determines the outcome of HBV infection as well as the impact of coinfections.
Construction and Mechanism Exploration of Highly Efficient System for Bacterial Ghosts Preparation Based on Engineered Phage ID52 Lysis Protein E
Authors: Ma Yi , Wang Sijia , Hong Bin , Feng Lan , Wang Jufang
Published: May 2024

Bacterial ghosts (BGs) are hollow bacterial cell envelopes with intact cellular structures, presenting as promising candidates for various biotechnological and biomedical applications. However, the yield and productivity of BGs have encountered limitations, hindering their large-scale preparation and multi-faceted applications of BGs. Further optimization of BGs is needed for the commercial application of BG technology. In this study, we screened out the most effective lysis protein ID52-E-W4A among 13 mutants based on phage ID52 lysis protein E and optimized the liquid culture medium for preparing Escherichia coli Nissle 1917 (EcN). The results revealed a significantly higher lysis rate of ID52-E-W4A compared to that of ID52-E in the 2xYT medium. Furthermore, EcN BGs were cultivated in a fermenter, achieving an initial OD600 as high as 6.0 after optimization, indicating enhanced BG production. Moreover, the yield of ID52-E-W4A-induced BGs reached 67.0%, contrasting with only a 3.1% yield from φX174-E-induced BGs. The extended applicability of the lysis protein ID52-E-W4A was demonstrated through the preparation of Salmonella pullorum ghosts and Salmonella choleraesuis ghosts. Knocking out the molecular chaperone gene slyD and dnaJ revealed that ID52-mediated BGs could still undergo lysis. Conversely, overexpression of integral membrane enzyme gene mraY resulted in the loss of lysis activity for ID52-E, suggesting that the lysis protein ID52-E may no longer rely on SlyD or DnaJ to function, with MraY potentially being the target of ID52-E. This study introduces a novel approach utilizing ID52-E-W4A for recombinant expression, accelerating the BG formation and thereby enhancing BG yield and productivity.
A Clinical Analysis of Anti-Programmed Death-Ligand 1 (PD-L1) Immune Checkpoint Inhibitor Treatments Combined with Chemotherapy in Untreated Extensive-Stage Small-Cell Lung Cancer
Authors: Hsu Ping-Chih , Wu Bing-Chen , Wang Chin-Chou , Chiu Li-Chung , Chang Chiung-Hsin , Liu Ping-Chi , Wu Chiao-En , Kuo Scott Chih-Hsi , Ju Jia-Shiuan , Huang Allen Chung-Cheng , Lin Yu-Ching , Yang Cheng-Ta , Ko How-Wen
Published: May 2024

Real-world clinical experience of using anti-programmed death-ligand 1 (PD-L1) immune checkpoint inhibitors (ICIs) combined with chemotherapy in the first-line treatment of extensive-stage small-cell lung cancer (SCLC) patients has rarely been reported. In this study, we aimed to perform a retrospective multicenter clinical analysis of extensive-stage SCLC patients receiving first-line therapy with anti-PD-L1 ICIs combined with chemotherapy. Between November 2018 and March 2022, 72 extensive-stage SCLC patients receiving first-line atezolizumab or durvalumab in combination with chemotherapy, according to the cancer center databases of Linkou, Chiayi, and Kaohsiung Chang Gung Memorial Hospitals, were retrospectively included in the analysis. Twenty-one patients (29.2%) received atezolizumab and fifty-one (70.8%) received durvalumab. Objective response (OR) and disease control (DC) rates of 59.7% and 73.6%, respectively, were observed with first-line ICI plus chemotherapy. The median progression-free survival (PFS) was 6.63 months (95% confidence interval (CI), 5.25–8.02), and the median overall survival (OS) was 16.07 months (95% CI, 15.12–17.0) in all study patients. A high neutrophil-to-lymphocyte ratio (NLR; >4) and a high serum lactate dehydrogenase (LDH) concentration (>260 UL) were identified as independent unfavorable factors associated with shorter OS in the multivariate analysis. Regarding safety, neutropenia was the most common grade 3 treatment-related adverse event (AE), but no treatment-related deaths occurred in the study patients. First-line anti-PD-L1 ICIs combined with chemotherapy are effective and safe for male extensive-stage SCLC patients. Further therapeutic strategies may need to be developed for patients with unfavorable outcomes (e.g., baseline high NLR and serum LDH level).
Evaluation of Swine Protection with Three Commercial Foot-and-Mouth Disease Vaccines against Heterologous Challenge with Type A ASIA/G-VII Lineage Viruses
Authors: Kim Seon Woo , Lee Seung Heon , Kim Ha-Hyun , Shin Sung-Ho , Park Sang-Hyun , Park Jong-Hyeon , Kim Jaejo , Park Choi-Kyu
Published: May 2024

Outbreaks caused by foot-and-mouth disease (FMD) A/ASIA/G-VII lineage viruses have often occurred in Middle Eastern and Southeast Asian countries since 2015. Because A/ASIA/G-VII lineage viruses are reported to have distinct antigenic relatedness with available commercial FMD vaccine strains, it is necessary to investigate whether inoculation with vaccines used in Korea could confer cross-protection against A/ASIA/G-VII lineage viruses. In the present study, we conducted two vaccination challenge trials to evaluate the efficacy of three commercial FMD vaccines (O/Manisa + O/3039 + A/Iraq, O/Campos + A/Cruzeiro + A/2001, and O/Primorsky + A/Zabaikalsky) against heterologous challenge with ASIA/G-VII lineage viruses (A/TUR/13/2017 or A/BHU/3/2017 strains) in pigs. In each trial, clinical signs, viremia, and salivary shedding of virus were measured for 7 days after challenge. In summary, the O/Campos + A/Cruzeiro + A/2001 vaccine provided full protection against two A/ASIA/G-VII lineage viruses in vaccinated pigs, where significant protection was observed. Although unprotected animals were observed in groups vaccinated with O/Manisa + O/3039 + A/Iraq or O/Primorsky + A/Zabaikalsky vaccines, the clinical scores and viral RNA levels in the sera and oral swabs of vaccinated animals were significantly lower than those of unvaccinated controls.
Local Immune Activation and Age Impact on Humoral Immunity in Mice, with a Focus on IgG Sialylation
Authors: Gupta Priti , Sághy Tibor , Bollmann Miriam , Jin Tao , Ohlsson Claes , Carlsten Hans , Corciulo Carmen , Engdahl Cecilia
Published: May 2024

Age alters the host’s susceptibility to immune induction. Humoral immunity with circulating antibodies, particularly immunoglobulin G (IgG), plays an essential role in immune response. IgG glycosylation in the fragment crystallizable (Fc) region, including sialylation, is important in regulating the effector function by interacting with Fc gamma receptors (FcγRs). Glycosylation is fundamentally changed with age and inflammatory responses. We aimed to explore the regulation of humoral immunity by comparing responses to antigen-induced immune challenges in young and adult mice using a local antigen-induced arthritis mouse model. This study examines the differences in immune response between healthy and immune-challenged states across these groups. Our initial assessment of the arthritis model indicated that adult mice presented more severe knee swelling than their younger counterparts. In contrast, we found that neither histological assessment, bone mineral density, nor the number of osteoclasts differs. Our data revealed an age-associated but not immune challenge increase in total IgG; the only subtype affected by immune challenge was IgG1 and partially IgG3. Interestingly, the sialylation of IgG2b and IgG3 is affected by age and immune challenges but not stimulated further by immune challenges in adult mice. This suggests a shift in IgG towards a pro-inflammatory and potentially pathogenic state with age and inflammation.
Sociodemographic Trends and Correlation between Parental Hesitancy towards Pediatric COVID-19 Vaccines and Routine Childhood Immunizations in the United States: 2021–2022 National Immunization Survey—Child COVID Module
Authors: Olusanya Olufunto A. , Masters Nina B. , Zhang Fan , Sugerman David E. , Carter Rosalind J. , Weiss Debora , Singleton James A.
Published: May 2024

Multiple factors may influence parental vaccine hesitancy towards pediatric COVID-19 vaccines and routine childhood immunizations (RCIs). Using the United States National Immunization Survey—Child COVID Module data collected from parents/guardians of children aged 5–11 years, this cross-sectional study (1) identified the trends and prevalence estimates of parental hesitancy towards pediatric COVID-19 vaccines and RCIs, (2) examined the relationship between hesitancy towards pediatric COVID-19 vaccines and RCIs, and (3) assessed trends in parental hesitancy towards RCIs by sociodemographic characteristics and behavioral and social drivers of COVID-19 vaccination. From November 2021 to July 2022, 54,329 parents or guardians were interviewed. During this 9-month period, the proportion of parents hesitant about pediatric COVID-19 vaccines increased by 15.8 percentage points (24.8% to 40.6%). Additionally, the proportion of parents who reported RCIs hesitancy increased by 4.7 percentage points from November 2021 to May 2022 but returned to baseline by July 2022. Over nine months, parents’ concerns about pediatric COVID-19 infections declined; however, parents were increasingly worried about pediatric COVID-19 vaccine safety and overall importance. Furthermore, pediatric COVID-19 vaccine hesitancy was more prevalent among parents of children who were White (43.2%) versus Black (29.3%) or Hispanic (26.9%) and those residing in rural (51.3%) compared to urban (28.9%) areas. In contrast, RCIs hesitancy was higher among parents of children who were Black (32.0%) versus Hispanic (24.5%) or White (23.6%). Pediatric COVID-19 vaccine hesitancy was 2–6 times as prevalent among parents who were RCIs hesitant compared to those who were RCIs non-hesitant. This positive correlation between parental hesitancy towards pediatric COVID-19 vaccines and RCIs was observed for all demographic and psychosocial factors for unadjusted and adjusted prevalence ratios. Parent–provider interactions should increase vaccine confidence, shape social norms, and facilitate behavior change to promote pediatric vaccination rates.
Prevalence and Risk Factors of Human Taenia solium Cysticercosis in Mbulu District, Northern Tanzania
Authors: Bandi Vedasto , Ngowi Bernard , Mpolya Emmanuel , Kilale Andrew Martin , Vianney John-Mary
Published: May 2024

Background: Taeniosis and cysticercosis are human infections caused by the pork tapeworm, Taenia solium. This study is a baseline for community-based intervention. We determined the prevalence of human cysticercosis and associated risk factors following a deworming program conducted throughout the country, with Mbulu District being among the districts in Northern Tanzania. Methods: Human cysticercosis was determined by enzyme-linked immunosorbent assay (Ag- ELISA). Household interviews and observations were conducted to identify risk factors for cysticercosis transmissions among households and communities. Results: Three hundred individuals participated in this study. The age ranged from 5 to 89 years, with a median of 19 years. The prevalence of human cysticercosis was 23 (7.67%). The prevalence was high with 6 (11.76%) among individuals aged 26 to 35 years and ±45 years. There was no statistically significant difference in the prevalence by age group, sex, or occupation. Among the 300 participants, 82 (27.3%) had received anthelmintics during the previous year; among these, 5 (21.7%) were infected. The likelihood of infection was low among anthelmintic users by 28% [0.72 (0.26–2.01)], but the protection was not significant. The communities differed in risk factors on the availability of a clean and safe water supply; 52.7% (46/86) of households visited had no pit latrine. The cysticercosis prevalence showed a significant difference in communities. Conclusions: The prevalence of human cysticercosis was high and associated with higher age groups. The prevalence was low among those who had taken anthelmintics and was associated with lower age groups. The current school deworming program has a positive effect on school children, while the elderly are at higher risk because the intervention did not target them. It is recommended to scale up anthelmintic intervention to higher age groups.
The Problem of the Jewish Holocaust
Authors: Malkin Vitaly
Published: May 2024

I assert that believers cannot exonerate god from being responsible for the evil in the world. God has shown conclusively that he is the source of all evil and suffering, and he should therefore answer for the harm caused to humanity in his name. Good intentions do not count. Is it possible that this evil and this suffering were necessary? I would like to focus on horrendous suffering in this chapter with a description of Absolute Evil. It is a sort of evil that casts a shadow over Hebrew, Christian, and Islamic gods. I am talking about the Holocaust.
Pengembangan Aplikasi Manajemen Persediaan untuk Meningkatkan Efisiensi Operasional
Authors: Winata Erick , Ayuningtyas Ayuningtyas , Putra I Gusti Ngurah Alit Widana
Published: May 2024

Sistem informasi telah terbukti bermanfaat dalam banyak bidang perusahaan, termasuk manajemen, produksi, pengambilan keputusan, penyelesaian masalah, dan peningkatan kualitas. Penggunaan teknologi komputer dalam sistem informasi memfasilitasi penyimpanan, pengolahan, dan presentasi data yang user-friendly. Data yang diproses dengan baik menjadi informasi berharga yang mendukung proses pengambilan keputusan. Salah satunya merupakan data stok barang yang digunakan untuk informasi persediaan barang dari suatu perusahaan. Bfit Indonesia merupakan perusahaan yang mengkhususkan diri dalam penjualan berbagai produk fitness dan menerapkan sistem informasi sebagai penyimpanan data stok barang. Divisi gudang harus melakukan pengecekan data melalui sistem informasi divisi administrasi yang kurang akurat dan efisien yang membuat dvisi gudang harus melakukan pencatatan manual agar memperoleh data yang lebih akurat. Oleh sebab itu, pengembangan aplikasi manajemen persediaan menggunakan Safety Stock dan Reorder Point ini bertujuan membuat aplikasi manajemen persediaan khusus untuk Bfit Indonesia guna mempermudah pengelolaan gudang secara efisien dan memberikan informasi terkini tentang status persediaan barang menggunakan metode Prototype dengan berbasis website. Aplikasi dapat menampilkan daftar persediaan gudang, menambahkan, mengurangi, dan mengedit persediaan barang. Aplikasi yang dikembangkan juga dapat mencetak daftar dan menyimpan log aktivitas barang. Aplikasi yang telah dikembangkan diuji menggunakan pengujian Black-box dengan hasil pengujian sesuai dengan harapan peneliti. Dengan aplikasi yang telah dikembangkan ini diharapkan dapat memberikan kemudahan bagi bagian gudang dalam mengelola persediaan dengan lebih efisien, serta menyediakan informasi yang lebih terkini dan akurat mengenai status persediaan barang.
Analisis Manajemen Risiko SIMRS pada Rumah Sakit Ganesha Menggunakan ISO 31000
Authors: Putra I Putu Andika Subagya , Hendrawan I Komang Risky
Published: May 2024

Rumah sakit adalah fasilitas kesehatan yang memberikan pelayanan pengobatan dan perawatan kepada pasien. Dalam konteks rumah sakit, pentingnya pengelolaan data dan informasi semakin meningkat karena pentingnya perbedaan fungsi dan informasi dalam pengambilan keputusan medis dan administratif. Di era teknologi informasi saat ini, peran teknologi sangatlah penting, SIMRS (Sistem Informasi Manajemen Rumah Sakit) adalah salah satu contoh penerapan teknologi tersebut. Penggunaan SIMRS diharapkan dapat meningkatkan efisiensi operasional namun juga meningkatkan risiko yang perlu dikelola dengan baik. Tujuan dari penelitian ini adalah untuk mengelola risiko pada SIMRS Rumah Sakit Ganesha dengan menggunakan framework ISO 31000. Dengan penelitian ini diharapkan rumah sakit dapat meningkatkan efisiensi dan efektivitas operasional mereka. Metode penelitian menggunakan kualitatif. Tahapan investigasi meliputi identifikasi aset, identifikasi risiko, analisis risiko, penilaian risiko, manajemen risiko, pencatatan dan pelaporan. Hasil analisis menunjukkan terdapat risiko tinggi dan menengah yang perlu diperhatikan, seperti risiko pada pemadaman listrik dan kehilangan data pasien. Pengelolaan risiko dilakukan dengan memberikan rekomendasi untuk mengatasi risiko yang teridentifikasi, seperti pemasangan genset untuk mengatasi risiko pada pemadaman listrik. Kemudian, hasil penanganan risiko dicatat dan dikirimkan ke organisasi untuk ditinjau. Kesimpulannya, manajemen risiko penting untuk mengatasi risiko terkait penggunaan SIMRS di Rumah Sakit Ganesha. Dengan mematuhi ISO 31000, diharapkan risiko-risiko tersebut dapat dimitigasi secara efektif untuk meminimalkan dampak negatif terhadap operasional rumah sakit.
The determinants of Vietnam’s outward foreign direct investment: the push factors approach
Authors: Quang Phung Thanh , Linh Nguyen Nhat
Published: May 2024

In the context of integration, in addition to increasing foreign capital inflows, Vietnamese enterprises are becoming more and more interested in outward foreign direct investment activities. This research expands the Investment Development Path model to assess the influence of some macroeconomic factors (GNI per capita, the proportion of expenditure on science and technology, FDI flows, USD to VND exchange rate, total import-export turnover) on Vietnam's outward foreign direct investment (OFDI) flows. Using the 32-year dataset (1989-2020), the regression results depict that the proportion of expenditure on science and technology, the amount of FDI, GNI per capita had a positive impact on the capital OFDI of Vietnam. However, the growth rate of total import-export turnover harmed OFDI flows in the same period. Meanwhile, the difference variable of exchange rate USD to VND in the multiple regression model was not statistically significant. Based on regression model results combined with qualitative studies, the authors propose some policy implications to promote OFDI flows of Vietnam in the near future.
Giant liver cyst associated with cholelithiasis: literature review and state of art
Authors: Weiss Marcelo Barros , Weiss Daniel de Souza
Published: May 2024

Liver lesions subject to laparoscopic resection are one of the frontiers conquered in surgery today. Even when dealing with surgery, which is often complex, the increase in demand from patients has increased, bringing more and more learning and dexterity to surgery teams with the increasing development of technology. To analytically evaluate the method, based on the most recent publications in the literature, with possible indications and reporting a recently successfully operated case, highlighting the safety, results and fundamental technical aspects. The relevant works from the last 15 years were identified and analyzed in the LILACS and PUBMED databases until August 2023, using the descriptors “ liver resection ”, “ laparoscopic surgery ” and “ liver surgery ”. We don't We found prospective and double-blind studies in the databases, with available data coming from case series, case-control studies and some multicenter studies and meta-analyses. Laparoscopic hepatectomy is a safe surgery and is very standardized in execution, even for major liver resections, with a low morbidity and mortality rate. As an oncological surgical method, it is gaining more and more space without compromising oncological radicality and with advantages for patients.  with specific liver diseases. Benign lesions are the best indicated and performed, especially adenoma and cystic lesions, which in the hands of experienced teams have very good results and videolaparoscopic surgery can be considered today as standard treatment.
Abordagens personalizadas no tratamento da hipertensão arterial: otimização da terapia farmacológica com base em fatores individuais
Authors: Araujo Bianka Cavalcante Vieira , Santos João Vitor Ragazi dos , Duarte Junia Borges , Abreu Eduarda Teixeira , Rassilan Felipe da Cunha
Published: May 2024

A hipertensão arterial sistêmica (HAS), condição crônica multifatorial, com definições de diagnóstico variadas e impactos significativos na saúde pública. Destaca-se sua prevalência global, complicações graves como doenças cardiovasculares e acidentes vasculares cerebrais, e os altos custos relacionados ao tratamento e complicações associadas, enfatizando a importância da gestão eficaz da HAS para a saúde e economia. Determinar os impactos de diferentes abordagens personalizadas no tratamento da hipertensão arterial. Revisão integrativa, realizando buscas sistemáticas nas bases de dados MEDLINE e SciELO.  A eficácia dos diuréticos distais à restrição dietética de sódio na hipertensão renal apresentam resultados consideráveis, assim como, os efeitos das isoflavonas de soja e o papel do GDF-15 como biomarcador na regulação da pressão arterial, conferindo benefícios em associação com o treinamento físico aeróbico em pacientes com hipertensão resistente A associação medicamentosa de diferentes fármacos anti-hipertensivos com mecanismos de ação diferentes têm demonstrado mais eficiência do que o tratamento monoterápico. Além do mais, estratégias voltadas para tecnologias de saúde que incluem mudanças nos hábitos de vida influenciam no tratamento. O tratamento com hidroclorotiazida e amilorida demonstrou eficácia semelhante ou superior a restrição dietética de sódio na regulação da pressão arterial, mesmo em pacientes com doença renal crônica e baixa taxa de filtração glomerular. Além disso, o uso de uma única pílula combinada apresentou eficiência no tratamento da hipertensão, com menor necessidade de medicamentos adicionais e melhor controle da PA ao longo do tempo. Ressalta-se a importância da seleção criteriosa de medicamentos anti-hipertensivos para prevenir eventos cardiovasculares. Enquanto os diuréticos tiazídicos incorporam eficácia na redução do risco de infarto e insuficiência cardíaca e AVC, as combinações desses medicamentos oferecem benefícios adicionais, especialmente em pacientes de alto risco. Além disso, destaca-se a relevância da diurese no controle da pressão arterial, especialmente em pacientes com Doença Renal Crônica (DRC). A adesão ao tratamento deve ser incentivada lançando mão de tecnologias educativas e de monitoramento remoto, agregado a mudanças no estilo de vida antes da intervenção farmacológica em adultos jovens com baixo risco cardiovascular. Desta forma, sugere a implementação de pílulas combinadas para melhorar a adesão ao tratamento, sendo necessárias mais pesquisas sobre sua segurança e eficácia a longo prazo.
Impactos da diversidade de informações sobre a pandemia de COVID-19 no conhecimento e comportamento populacional, no município de Araras – SP
Authors: Almeida Giovanna Xavier de , Zago Patricia Maria Wiziack , Zago Ana Cristina Wiziack
Published: May 2024

No fim de 2019, em Wuhan, na China, foi descoberto um novo coronavírus causador da doença COVID-19. Depois, diversos casos da doença foram identificados pelo mundo e o vírus se espalhou, causando uma pandemia. Até hoje, faltam informações sobre essa patologia e seu vírus causador, principalmente quanto a seus tratamento e prevenção, levando à disseminação de pseudoinformações e de notícias equívocas sobre variados aspectos da COVID-19, o que favoreceu a prática de comportamentos de risco pela população. Conforme exposto acima, fez-se necessário analisar o quão grave foi o impacto da replicação descontrolada de informações ludibriosas sobre o novo coronavírus e sobre a COVID-19. Assim, foi realizada uma pesquisa aprofundada acerca dos danos causados na saúde pública pelo alastramento de tais notícias sendo a população da cidade de Araras escolhida para análise da dimensão dessas implicações por meio de entrevistas semi-estruturadas.
Pancreatite aguda - revisão literária
Authors: Silvestri Luiza Mattos , Souza Gabriela Neves de , Gomes Marina Nascimento , Pizzinatto Natacha Luiza , Araújo João Pedro de Almeida , Oliveira Julia Schreiber Melo de , Magalhães Maria Regina Marques , Venâncio Rafael de Morais , Castro Renata Costa Café de , Rocha Junio Alves
Published: May 2024

A pancreatite aguda (PA) é uma condição caracterizada por um processo inflamatório agudo no pâncreas, muitas vezes desencadeado pela ativação anormal de enzimas pancreáticas. Esse distúrbio pode evoluir para uma resposta inflamatória sistêmica, resultando em uma ampla gama de sintomas e complicações, variando em gravidade. As causas da PA incluem litíase biliar, consumo excessivo de álcool, trauma abdominal, uso de medicamentos, infecções e outros fatores. A incidência global da doença tem aumentado, representando um desafio significativo para os sistemas de saúde, com taxas de mortalidade elevadas em casos graves. Ademais, os pacientes com PA podem apresentar desde sintomas leves e autolimitados até quadros de falência orgânica, o que pode resultar em morbidade e mortalidade significativas. O diagnóstico é geralmente feito com base em elevações nos níveis séricos de lipase e dor abdominal característica, embora exames de imagem como a tomografia computadorizada possam ser utilizados em casos de dúvida diagnóstica. O tratamento inicial da PA consiste em medidas de suporte, incluindo oxigênio, ressuscitação volêmica, analgesia e nutrição adequada. Em casos graves, cuidados intensivos e suporte ventilatório podem ser necessários. O manejo cirúrgico pode ser indicado em casos de complicações como infecção, necrose pancreática ou falência de órgãos, com diferentes abordagens disponíveis, desde drenagem percutânea até necrosectomia pancreática aberta.As complicações da PA podem ser locais, como necrose pancreática e coleções líquidas, ou sistêmicas, incluindo disfunção de múltiplos órgãos e sepse. O tratamento depende da gravidade e das complicações específicas de cada caso, com o objetivo de reduzir a morbimortalidade associada à doença.Em resumo, a PA é uma condição inflamatória aguda do pâncreas com diversas causas e manifestações clínicas. Seu manejo envolve uma abordagem multidisciplinar, com foco na identificação precoce, tratamento adequado das complicações e suporte ao paciente para uma recuperação bem-sucedida.
PENGARUH SIKLUS HIDUP PERUSAHAAN TERHADAP KEPEMILIKAN KAS PADA PERUSAHAAN YANG TERDAFTAR DI INDEKS KOMPAS 100
Authors: Rahmawati Fitri , Cahyo Heru , Nirmala Nirmala
Published: May 2024

This study aims to determine the partial significance of the company's life cycle, leverage, profitability and company size on cash ownership of companies listed on the compass 100 index of the Indonesia Stock Exchange. The sampling method using purposive sampling obtained as many as 62 companies. The data analysis technique used is panel data regression. The results of data analysis show that the best model is the Fixed Effect Model with the results of the analysis of the expansion stage life cycle, stabilization stage life cycle and decline stage life cycle have a positive and significant effect on cash holdings. The implication of this research is that investors are expected to get an overview of the effect of the company's life cycle on the company's cash ownership policy. Companies in the stabilization stage have large cash holdings including for dividend payments, thus attracting the attention of investors to invest in these companies. By paying attention to the stages of the company's life cycle, it is hoped that it can minimize investor losses when investing and can provide maximum profit from investment. This research provides important understanding for company management in making decisions regarding cash allocation and risk management strategies.

Keywords: Corporate Life Cycle, Cash Ownership
Thermal Protection Performance of Biomimetic Flexible Skin for Deformable High-Speed Vehicles (DHSV-bio-FS) under Uniaxial Tensile Strain
Authors: Yuan Chao , Lü Xiaozhou , Bao Weimin
Published: May 2024

Vehicle skin is the key component in maintaining the aerodynamic shape of the vehicle. A deformable high-speed vehicle needs to adjust its shape in real time to realize optimum aerodynamic efficiency and to withstand extreme heat flow induced by high-speed flight, which requires the skin to possess large strain and high-temperature resistance. Traditional vehicle skin cannot satisfy both of the requirements. Biomimetic flexible skin for deformable high-speed vehicles (DHSV-bio-FS) combines flexible material fabrication with transpiration cooling technology, which can simulate human skin sweat cooling, and has the characteristics of large strain and high-temperature resistance. The thermal protection performance of the prepared prototype of DHSV-bio-FS was evaluated by simulation and wind tunnel experiments at 40% tensile strain with liquid water as coolant. Simulation results suggest that the surface temperature of the DHSV-bio-FS at 40% tensile strain is consistent with the temperature of the coolant (350 K) in a 3,000 K high-temperature gas environment. In addition, the prepared prototype DHSV-bio-FS survived for 1,200 s in a high-temperature gas environment of 200 kW/m
2
in wind tunnel experiments. This paper verifies the reliability of DHSV-bio-FS in a high-temperature gas environment and can be deployed in applications of flexible skin for deformable high-speed vehicles (DHSV-FS).
High Harmonic Generation Light Source with Polarization Selectivity and Sub-100-μm Beam Size for Time- and Angle-Resolved Photoemission Spectroscopy
Authors: Zhong Haoyuan , Cai Xuanxi , Bao Changhua , Wang Fei , Lin Tianyun , Chen Yudong , Peng Sainan , Tang Lin , Gu Chen , Tao Zhensheng , Zhang Hongyun , Zhou Shuyun
Published: May 2024

High-quality ultrafast light sources are critical for developing advanced time- and angle-resolved photoemission spectroscopy (TrARPES). While the application of high harmonic generation (HHG) light sources in TrARPES has increased substantially over the past decade, the optimization of the HHG probe beam size and selective control of the light polarization, which are important for TrARPES measurements, have been rarely explored. In this work, we report the implementation of high-quality HHG probe source with an optimum beam size down to 57 μm × 90 μm and selective light polarization control, together with mid-infrared (MIR) pumping source for TrARPES measurements using a 10-kHz amplifier laser. The selective polarization control of the HHG probe source allows to enhance bands with different orbital contributions or symmetries, as demonstrated by experimental data measured on a few representative transition metal dichalcogenide materials as well as topological insulator Bi
2
Se
3
. Furthermore, by combining the HHG probe source with MIR pumping at 2-μm wavelength, TrARPES on a bilayer graphene shows a time resolution of 140 fs, allowing to distinguish 2 different relaxation processes in graphene. Such high-quality HHG probe source together with the MIR pumping expands the capability of TrARPES in revealing the ultrafast dynamics and light-induced emerging phenomena in quantum materials.
Converged learning: the spectrum of technology-mediated learning
Authors: Lipuma James , Leon Cristo
Published: May 2024

New Jersey Institute of Technology (NJIT), a four-year polytechnic research university in the United States, utilized a participatory strategic planning process  to implement an innovative approach to the delivery modes between face-to-face and online instruction.   NJIT defines the spectrum of online and on-ground instruction integration as Converged Education. This spectrum allows students to participate face-to-face, join remotely through real-time video conferencing technology (synchronously), or watch classroom instruction asynchronously. The article opens with a general background of NJIT's approach to the new idea of converged instructional delivery.  Then, the process of defining and clarifying the terms and conceptions of the various modes to be adopted is presented.  Finally, the resulting implementation of the new policy and its reflection on course offerings is shown and discussed.
Densidad en una plantación de café (Coffea arábiga) variedad marsellesa con enfoque agroforestal
Authors: Rodríguez Lilia Ortiz , Pérez Arturo Morales , Suarez Carlos Cuevas , Soto Rodolfo Fernández , Romero Omar Ríos , Hernández Margarito Guerrero
Published: May 2024

El siguiente trabajo, se desarrolló en la zona centro montañosa del estado de Veracruz, dentro de la cuenca del río la antigua, en el municipio de Teocelo. Se utilizaron sitios de muestreo circulares de diámetro 17.84 m con una superficie de 1000 m2. Se recabó y se ajustaron modelos matemáticos para calcular factor de competencia de copas, variables como diámetro a la altura de 1.30m (DAP) de todos los individuos con DN ≥ 10 cm y diámetro de copa. La estructura arbórea en las unidades de muestreo las especies más identificadas fueron Inga edulis con un porcentaje de 55% quedando en segundo lugar la especie de Musa parasidiaca y para el factor de competencia de copas (FCC) en la especie de M. parasidiaca se obtuvo un 22 % para la categoría de 10 y 45 % para la categoría diamétrica de 20; para la especie de Inga edulis se obtuvo un 20 % dentro de la categoría de 10 que fue la mínima y la máxima ocupo la categoría de 30 con un FCC de 87%.
Práticas agroecológicas & a sustentabilidade do semiárido brasileiro
Authors: Jesus Edilma Nunes de , Feitosa Flávia Regina Sobral , Passos Karla Fabiany Santana , Santos Emanuela Carla , Pereira Alessandra Santana
Published: May 2024

A agroecologia pode ser considerada como ciência, prática e movimento social, que historicamente preza por caminhos mais sustentáveis, igualitários e justos do cultivo, manejo do solo e escoamento da produção alimentar. Assim, a agricultura familiar do semiárido nordestino se coaduna com os pressupostos da agroecologia, justamente pelo fato dos agricultores familiares e camponeses contribuírem diretamente para a perpetuação dos saberes agroecológicos. No semiárido, território de lutas e resiliência, essa relação é ainda mais evidente, pelo fato da agroecologia representar a sustentabilidade da produção de inúmeras famílias. Desta forma, este artigo visa verificar o papel da agroecologia como estratégia voltada para a promoção da sustentabilidade do semiárido especificamente, na agricultura familiar. Para isso, foram analisados de forma qualitativa, artigos selecionados dos últimos 05 (cinco) anos, por meio das plataformas da Scielo e periódicos CAPES que versassem sobre a importância da agroecologia para o semiárido. Conclui-se, nesta revisão bibliográfica, que diversas são as possibilidades e contribuições da agroecologia para o semiárido e percebe-se também que as estratégias agroecológicas estimulam os processos de organização e participação social em todas as suas práticas, pois percebe-se o ambiente como um organismo não estático, sistêmico e repleto de interações, sendo a base para a reconstrução social em modelos mais sustentáveis.
Adsorption of the Antibiotic Roxithromycin on Low-Cost Food Waste Materials: Batch and Column Studies
Authors: Tosun Satir Ilknur , Akmeşe Bediha
Published: May 2024

Antibiotics are widely utilized for a variety of medical conditions. Antibiotic residues in wastewater are dangerous to all living beings. Antibiotics remain in the wastewater environment when general treatment plant technologies are employed. The literature has numerous techniques for getting rid of antibiotics. Compared to other techniques for removing contaminants in the solution environment, the adsorption method is preferred due to its benefits, such as ease of use, high efficiency, and low cost. The study investigated using the green walnut shell (GWS), a natural sorbent, as an adsorbent to discharge roxithromycin (ROX) antibiotics from the solution medium. Adsorption conditions were studied in batch and continuous systems. pH, adsorbent amount, interaction time, sorbate concentration, and salt effect parameters were investigated in the batch system. The data obtained were calculated with kinetic and isotherm models. The adsorption process has been based on the so-called pseudo-second-order kinetic model. GWS was characterized using SEM and FTIR techniques. The amount of absorbent, flow rate, and breakdown in the continuous system were explored. In the batch system, the adsorption equilibrium was set up at the solution's original pH with 0.1 g of adsorbent in 40 minutes, and 79% ROX removal was achieved. The optimum flow rate and adsorbent amount in the continuous system were determined as 0.1 mL/min and 0.3 g, respectively.