bluuebunny/crossref_metadata_2025 huggingface dataset:
New perspectives on autism: two equations to describe a complex disorder and envisage new treatments
Authors: Suare B. , Jeune M.-A.
Published: January 2025

Autism spectrum disorder (ASD) is a neurodevelopmental condition that can be reliably diagnosed in children by age 18–24 months. Prospective longitudinal studies of infants aged 1 year and younger who are later diagnosed with autism are elucidating the early developmental course of autism and identifying ways of predicting autism before diagnosis is possible. Studies that use magnetic resonance imaging and electroencephalography, have identified differences in brain development in infants later diagnosed with autism compared with infants without autism. Retrospective studies of infants younger than 1 year who received a later diagnosis of autism have also showed an increased prevalence of health conditions, such as sleep disorders, gastrointestinal disorders, and vision problems. We propose two equations to describe this complex disorder: the first indicates the factors at the origin of the disease, the second synthesizes the different factors leading to a more or less severe disease. Although research findings offer insight on promising screening approaches for predicting autism in infants, individual-level predictions remain a future goal. Multiple scientific challenges and ethical questions remain to be addressed to translate research on early brain-based and behavioural predictors of autism into feasible and reliable screening tools for clinical practice.
Modern trends in medicine: from microbiome to systemic complications
Authors: Makatsariya A. D. , Vorobev A. V.
Published: January 2025

The articles in this issue cover a wide range of topics, including the role of the maternal microbiome in fetal growth restriction, the effectiveness of therapy for mixed vaginitis, management strategies for pregnant women with COVID-19, the impact of environmental factors on reproductive health, thrombotic complications of chemotherapy, the connection between the microbiome and obesity, as well as rare clinical cases. Innovations in diagnostics, treatment, and screening are explored, from non-invasive prenatal testing to mathematical models for studying autism. The articles emphasize the importance of a comprehensive approach and the integration of modern technologies.
The changes in individual characteristics of cell-free DNA in pathological processes caused by inflammation in patients with asthma and rheumatoid arthritis
Authors: Volskiy Nikolay N. , Demchenko Elena N , Goiman Elena V. , Filipenko Maksim L. , Gavrilova Elena D.
Published: January 2025

The changes in individual characteristics of cell-free DNA in pathological processes caused by inflammation in patients with asthma and rheumatoid arthritis
COMPARISON OF THE EFFECTIVENESS OF DISINFECTANTS FOR CLEANING COMPLETE REMOVABLE ACRYLIC DENTURES
Authors: Razumova Svetlana Nicolaevna , Brago Anzhela Stanislavovna , Serebrov Kirill Dmitrievich , Baikulova Malina Dzhandaurovna , Morozova Elena Anatolevna , Serebrov Dmitrii Vitalevich
Published: January 2025

STRUCTURED ANNOTATION
Justification: According to WHO data, there is a trend towards an increase in the number of elderly people. The problem of high-quality cleaning and disinfection of removable dentures remains relevant because methods and techniques for cleaning and disinfecting removable dentures that are known today do not always give acceptable results.
Purpose: prove the effectiveness of using the Anolyte ANK solution for disinfection of partial and complete removable dentures.
Materials and methods: during the study, the disinfecting properties of the Anolyte ANK solution were studied in comparison with a 0.05% chlorhexidine solution. 60 patients with complete removable acrylic dentures were examined. In group. The efficiency of denture cleaning was assessed using the mass spectrometry method on a Maestro-αMS gas chromatography-mass spectrometer.
Statistical survey methods: Statistical processing of the study results was carried out using the StatistiCa 13 computer package. Parametric tests were used to assess differences between groups, including t-test with Bonferroni correction for multiple comparisons. The critical level of statistical significance p was equal to 0.05.
Results
As a result of the study, it was found that the number of fungi and yeast after exposure in the Anolyte ANK solution decreased from 1846±81.0 to 125±33.0 (105 cells/gram) (p=0.03).
The number of anaerobic bacteria after exposure in the Anolyte ANK solution decreased from 154±9.0 to 10±3.0 (105 cells/gram ) (p=0.006).
The number of actinobacteria after exposure in the Anolyte ANK solution decreased from 163±30.0 (105 cells/gram) to 8±4.0 (105 cells/gram) (p=0.03).
After exposure in the Anolyte ANK solution the number of cocci and bacilli decreased from 135±11.0 (105 cells/gram) to 3±3.0 (105 cells/gram) (p=0.009).
Conclusion: The Anolyte ANK solution is effective against fungi and yeast on the surface of the denture, anaerobic microorganisms, actinobacteria, cocci and bacilli, the number of which decreases in proportion to the time of exposure of the denture in the solution (p=0.0001).
Mieć (bio)władzę: dziewiętnastowieczne narracje o menonitach na ziemiach polskich i ukraińskich
Authors: Pniewski Dariusz
Published: January 2025

Bohaterami artykułu są menoniccy osadnicy, zamieszkujący od XVI wieku tereny zalewowe dolnego biegu Wisły, a od końca XVIII wieku stepy nad Dnieprem. Unikalna wiedza hydrologiczna i rolnicza była tak użyteczna, że pozwoliła im zarówno na zachowanie tożsamości w obcym otoczeniu, jak i zapewnienie sobie ekonomicznego dobrobytu. W autobiograficznych narracjach opisujących codzienność osadników na Żuławach (wspomnienia pisane przez zewnętrznych obserwatorów) i na ziemiach obecnej Ukrainy (listy i raporty przywódcy osadników) zgodnie podkreślano najważniejsze cechy ich działań: pragmatyzm, celowość i efektywność. Zarówno w deltę Wisły, jak i deltę Dniepru sprowadzono ich ze względu na wiedzę rolniczą i przetwórczą, umiejętność hodowli zwierząt i doświadczenie w przygotowaniu ziemi do uprawy, umiejętność budowania młynów, umocnionych kanałów, grobli, urządzeń odwadniających. Potrafili zatem zarządzać gospodarką (nie tylko ekonomią, lecz – co dla mnie ważniejsze – rolnictwem i wodą), a także, jak wskazują wspomnienia osób, które miały możliwość poznać menonickie gospodarstwa, sugerować „styl ich odbioru” (narrację i idee). W tekście staram się odpowiedzieć na pytanie o to, jak wiedza, umiejętności i doświadczenie umożliwiały menonitom posiadanie różnego typu władzy. A władzę w tym kontekście rozumiem jako spójną politykę, koherentny, wielodziedzinowy zespół działań: rolniczych, technologicznych, społecznych i estetycznych (oraz ekonomicznych). Dlatego dobrym narzędziem do jej zbadania będą koncepcje biowładzy według Michela Foucaulta i Thomasa Lemkego. Istotne tło dla takiej interpretacji stworzy koncepcja literackiej polityki (Realpoetik) Paula Hamiltona i „laboratorium nowoczesności” Alexandra Etkinda.
„Cerkiew jest tak blisko bóżnicy”. Ukraińska przestrzeń geograficzno-kulturowa w Echu Juliana Stryjkowskiego
Authors: Wołk Marcin
Published: January 2025

Artykuł dotyczy roli, jaką w pisarstwie Stryjkowskiego pełni geograficzna i kulturowa przestrzeń Galicji Wschodniej / zachodniej Ukrainy jako tło wydarzeń fabularnych i środowisko życia bohaterów oraz osobny obiekt zainteresowania autora. Szczególną uwagę poświęcono relacji przestrzeni literackiej do realnej topografii Stryja i okolic oraz obrazowi kultury i społeczności ukraińskiej w odniesieniu do zajmującej centralne miejsce kultury żydowskiej. W utworze pojawiają się wtrącenia ukraińskojęzyczne, występują postaci ukraińskie, powtarza się motyw relacji erotycznych między reprezentantami społeczności żydowskiej i ukraińskiej. Kultura ukraińska zostaje ukazana jako bliska dla dużej części bohaterów żydowskich – kontaktują się oni zwłaszcza z wiejską ludnością rusińską, posługują się okazjonalnie językiem ukraińskim, podpatrują liturgię w greckokatolickiej cerkwi. Kontrastuje to z ukazaniem kultury polskiej i zdominowanej przez Polaków urzędniczej dzielnicy miasta jako przestrzeni obcych, niezrozumiałych i raczej nieprzyjaznych. Wyjątkiem jest polski język, pociągający dla dziecięcego bohatera – przyszłego pisarza. Stryjkowski z wielką dokładnością topograficzną odtwarza przestrzeń Stryja i okolic, wprowadza także liczne nazwiska i zawody zamieszkałych tam postaci udokumentowanych historycznie, w tym Ukraińców.
Niepowtarzalność jako kategoria konstytutywna w poezji Liny Kostenko (na podstawie polskich przekładów)
Authors: Szczepan-Wojnarska Anna
Published: January 2025

Artykuł odnosi się do twórczości poetyckiej ukraińskiej poetki Liny Kostenko, represjonowanej w okresie stalinowskim, reprezentantki szistdesiatnyków. Twórczość ta odzwierciedla najważniejsze procesy historyczne ostatniego stulecia i ukazuje złożone relacje tego, co uniwersalne i jednostkowe, momentalne i wieczne. Kategorią konstytutywną jej wierszy jest niepowtarzalność powiązana z otwarciem na dialog i odpowiedzialnością za dokonywanie wyborów. Niniejsze rozważania ukazują dynamikę istnienia, zaskakującą i paradoksalną, kiedy to, co osobiste, rzutuje na to, co pokoleniowe, historyczne, narodowe. Niepowtarzalność rozumiana jest szerzej niż oryginalność czy wyjątkowość. To niezwykle wyraziste dążenie ku prawdzie.
Evaluation of the Effectiveness of Diabetic Foot Ulcer Recurrence Risk Prediction Models: A Systematic Review
Authors: Li Zi-Qiang , Zhang Yan-Ping , Fu Gui-Fen , Chen Jing-Feng , Zheng Qiu-Ping , Xian Xiao-Min , Wang Miao
Published: January 2025

Background: We used the Predictive Model Bias Risk Assessment tool (PROBAST) tool to systematically evaluate the existing models worldwide, in order to provide a reference for clinical staff to select and optimize DFU recurrence risk prediction models.
Methods: Literature on DFU recurrence risk prediction model construction published in CNKI, China Biomedical Literature Database, Vipu China Knowledge, China Biomedical Literature Database, Vipu Chinese Journal Service Platform, Wanfang Data Knowledge Service Platform, Embase, PubMed, Web of Science, Cochrane Library and other databases were systematically searched. The search period was until January 29, 2024, encompassing all relevant studies published up to that date. Literature screening and data extraction were conducted by two researchers, and the PROBAST was used to evaluate the bias risk and applicability of the included literature.
Results: Finally, 9 literatures were included, 13 prediction models were established, and the area under the AUC or C-index ranged from 0.660 to 0.943. Nine models were validated internally and one model was validated externally. All the models constructed in the included literature are of high-risk bias, and the applicability of the models is reasonable. Common predictors in the prediction model were Wagner scale, glycosylated hemoglobin, and diabetic peripheral neuropathy.
Conclusion: Although most of the existing DFU risk prediction models have good prediction performance, they all have high risk of bias. It is suggested that researchers should update the existing models in the future, and future modeling studies should follow the reporting norms, so as to develop a scientific, effective and convenient risk prediction model that is more conducive to clinical practice.
Effectiveness of Couple Interventions in Marital Distress: A Systematic Review and Meta-Analysis
Authors: Joseph Binu , Joseph Varghese K. , Rajan Santhosh Kareepadath
Published: January 2025

Background: Couple interventions focus on resolving relationship issues and improving partners' intimacy. Several intervention models are used on different occasions to deal with the issues. The present systematic review and meta-analysis investigated the effectiveness of such couple interventions dealing with marital distress.
Methods: Using the PRISMA guidelines for reporting systematic reviews and meta-analyses, a search was carried out to identify published articles in the areas of study. The meta-analysis investigated the effectiveness of couple interventions by comparing the post-intervention assessments of the experimental and control groups.
Results: The systematic review helped to identify twelve empirical studies published within the last ten years in the following databases: ScienceDirect, EBSCO, APA PsycINFO, NCBI, ProQuest, and Google Scholar. Meta-analysis showed a statistically significant overall effect size (Cohen's d = 0.85, 95% CI: 0.56 - 1.14). Cochran's Q showed that there was a substantial difference between the studies. There were signs of publication bias.
Conclusion: The current study revealed an overall large effect size, indicating that different couple interventions had a noticeable impact on distressed couples who received interventions as opposed to couples who did not receive any interventions.
Analysis of Correlation between Nutritional Behavior, Lifestyle and Symptoms of Depression, Anxiety among Students
Authors: Dimovic Tamara , Janicijevic Nikoleta , Stajic Dalibor , Djonovic Nela , Vasiljevic Dragan , Vuckovic-Filipovic Jelena , Vojinovic Radisa , Grujicic Mladen , Potezica Milos , Radovanovic Jovana , Selakovic Viktor , Janicijevic Katarina , Radovanovic Snezana , Mihaljevic Olgica , Sekulic Marija
Published: January 2025

Background: Students making the transition from high school to university find it difficult to maintain good eating routines/lifestyles and mental health, due to time constraints and stress. The goal of the study was to analyse the correlation between previously mentioned topics.
Methods: We included 948 students, aged 18-27, at the Faculty of Medical Sciences in Serbia and the research was conducted in 2020. Chi-square was used for statistical analysis. Modified WHO questionnaire for lifestyle and eating habits was used, as well as standardized questionnaires for anxiety and depression.
Results: Respondents who had more prominent symptoms of depression (moderate or severe) and anxiety had a significantly higher percentage of eating less than three meals a day (47.7%, 35.7%), skipped breakfast (38.6%, 33.5%), consumed alcohol (11.4%, 3.8%), used energy drinks (38.6%, 31.7%), were on some type of diet (36.6%, 30.2%), were not satisfied with their appearance (66.7%, 53%) and not engaging in physical activity (43.2%, 33.1%). Significant predictors for severe depressive and anxiety symptoms were the consumption of alcoholic beverages, energy drinks, satisfaction with personal appearance and physical activity during a day.
Conclusion: The results suggest that some of the eating and lifestyle habits were linked to higher risks of developing depressive or anxiety symptoms.
How Do Economic Disparities Lead to Health Inequalities?
Authors: Kirkova-Bogdanova Angelina G.
Published: January 2025

The Article Abstract is not available.
Predicting the Occurrence of Preterm Birth and Determining its Risk Factors Individually Using an Interpretable Machine Learning Model
Authors: Farrokhi Ramin , Hosseinzadeh Samaneh , Habibelahi Abbas , Biglarian Akbar
Published: January 2025

Background and Objectives: Identifying pregnant women who are at risk of premature birth and determining its risk factors is essential because it affects their health. This study aimed to use an interpretable machine-learning model to predict premature birth.
Methods: In this study, data from 149,350 births in Tehran in 2019 were utilized from the Iranian Mothers and Babies Network (IMaN) dataset. Various factors related to the mother and the fetus, such as the mother's demographic variables and health status, medical history, pregnancy conditions, childbirth, and associated risks, were considered. The machine learning models, including multilayer neural networks, random forest, and XGBoost, were employed to predict the occurrence of preterm birth after data preprocessing. The models were evaluated based on accuracy, sensitivity, specificity, and area under the ROC curve. The Python programming language version 3.10.0 was applied to analyze the data.
Results: About 8.67% of births were premature. The XGBoost algorithm achieved the highest prediction accuracy (90%). According to the model output, multiple births, which account for 46% of pregnant women's births, had the highest importance score. Delivery risk factors had a score of 41%, and other variables, including neurological and mental illness, preeclampsia, and cardiovascular disease, were subsequently ranked in order of importance for this particular individual.
Conclusion: Using an interpretable machine learning method could predict the occurrence of premature birth. Based on risk factors, the interpretable machine learning method can provide personalized preventive recommendations for every pregnant woman, aiming to reduce the risk of preterm birth.
Vpliv podnebnih sprememb na mestno drevnino: primer Velenja 2008–2023
Authors: Pajk Barbara , Dolejši Nataša
Published: January 2025

Članek obravnava vpliv podnebnih sprememb na mestno drevnino na javnih površinah Mestne občine Velenje med letoma 2008 in 2023. Cilj je ugotoviti, koliko in katera drevesa zastopanih drevesnih vrst so izginila in katera še rastejo ter analizirati vzroke za te spremembe. Rezultati kažejo, da so podnebne spremembe in ekstremni vremenski dogodki ter urbanizacija pomembno vplivali na nihanje števila dreves zastopanih drevesnih vrst na javnih površinah občine. Raziskava poudarja pomen zelene infrastrukture za izboljšanje mikroklimatskih razmer in kakovosti življenja v urbanem okolju. Izpostavljena je potreba po trajnostnem načrtovanju in upravljanju dreves, kar vključuje sajenje novih in ohranjanje obstoječih dreves. Poročilo vključuje tudi posodabljanje katastra dreves, ki je dostopen na spletu.
USABILIDADE DA PLATAFORMA DIGITAL “BE ACTIVE”: experiências na formação de docentes universitários
Authors: Guelfi Adilson Eduardo , Melo André Luiz Rossetti de , Santos Danielle Aparecida do Nascimento dos , Sousa Sidinei de Oliveira , Vargas Vinícius Fagundes
Published: January 2025

Neste artigo descrevem-se os processos de aplicação e usabilidade da Plataforma Digital “Be Active” na formação continuada de docentes de uma Instituição de Ensino Superior (IES). A Be Active é uma plataforma educacional digital criada por uma equipe multidisciplinar vinculada a uma universidade privada do interior do Estado de São Paulo que permite aplicar de forma síncrona e/ou assíncrona, diagnósticos de estilos de aprendizagem e metodologias ativas de aprendizagem. Diante da necessidade de avaliação da usabilidade da plataforma e da sua disseminação como recurso educacional no ensino universitário, o objetivo foi realizar oficinas práticas usando os recursos da “Be Active” no contexto da formação continuada de docentes universitários. A abordagem metodológica é qualitativa do tipo analítico-descritiva, detalhando-se os processos de observação participante, elaborados por meio da descrição e apresentação dos resultados obtidos nas experiências formativas que consistiram em oficinas práticas realizadas em janeiro de 2023. Foram realizadas oficinas sobre Estilos de Aprendizagem e sobre a Metodologia ativa Peer Instruction. Os resultados obtidos na realização das oficinas demonstram a importância da disseminação e do uso da plataforma digital “Be Active” como um recurso inovador para a prática docente.
The interplay between RNA m6A modification and radiation biology of cancerous and non-cancerous tissues: a narrative review
Authors: Cheng Yajia , Shang Yue , Zhang Shuqin , Fan Saijun
Published: January 2025

The diverse radiation types in medical treatments and the natural environment elicit complex biological effects on both cancerous and non-cancerous tissues. Radiation therapy (RT) induces oncological responses, from molecular to phenotypic alterations, while simultaneously exerting toxic effects on healthy tissue. N6-methyladenosine (m6A), a prevalent modification on coding and non-coding RNAs, is a key epigenetic mark established by a set of evolutionarily conserved enzymes. The interplay between m6A modification and radiobiology of cancerous and non-cancerous tissues merits in-depth investigation. This review summarizes the roles of m6A in the biological effects induced by ionizing radiation and ultraviolet (UV) radiation. It begins with an overview of m6A modification and its detection methods, followed by a detailed examination of how m6A dynamically regulates the sensitivity of cancerous tissues to RT, the injury response in non-cancerous tissues, and the toxicological effects of UV exposure. Notably, this review underscores the importance of novel regulatory mechanisms of m6A and their potential clinical applications in identifying epigenetically modulated radiation-associated biomarkers for cancer therapy and estimation of radiation dosages. In conclusion, enzyme-mediated m6A-modification triggers alterations in target gene expression by affecting the metabolism of the modified RNAs, thus modulating progression and radiosensitivity in cancerous tissues, as well as radiation effects on normal tissues. Several promising avenues for future research are further discussed. This review highlights the importance of m6A modification in the context of radiation biology. Targeting epi-transcriptomic molecules might potentially provide a novel strategy for enhancing the radiosensitivity of cancerous tissues and mitigating radiation-induced injury to normal tissues.
Validation of Quantitative Light-Induced Fluorescence Digital Analysis for the Assessment of Transverse Sectional Early Dental Caries Using Micro-Computed Tomography as a Reference Standard: An In Vitro Study
Authors: Min Ji-Hyun
Published: January 2025

Objectives: The aim of this study was to validate the effectiveness of quantitative light-induced fluorescence digital (QLFD) analysis for assessing mineral loss in transverse sections of early dental caries (EDC) by comparing it with micro-computed tomography (µCT). Methods: Artificial EDC lesions were created by immersing bovine enamel samples in a demineralization solution for periods ranging from 10 to 70 days. The enamel samples were then sectioned transversely and analyzed using QLFD and µCT to capture and assess the cross-sectional images. Grayscale intensity profiles were generated on a scale of 0 to 100, and thresholds of 90% and 95% grayscale intensity were defined to determine the depth of EDC. The lesion depths obtained from both methods were statistically compared and evaluated using paired t-tests, one-way ANOVA, and linear regression analysis. Results: The findings revealed a significant increase in enamel lesion depth over demineralization periods ranging from 10 to 70 days at both 90% and 95% grayscale intensity thresholds (p<0.001). QLFD consistently demonstrated greater enamel lesion depths compared to µCT across all demineralization stages. A strong positive correlation was observed between QLFD and µCT (r = 0.836–0.962, p < 0.001), with R² values of 0.797 and 0.720 for the 90% and 95% grayscale intensity thresholds, respectively, in linear regression models. Conclusions: This study confirms that QLFD can reliably quantify the depth and progression of EDC in transverse sections. QLFD has been proven to be a practical and suitable method for replacing µCT in laboratory settings for the study of EDC.
Immobilization of Phospholipase D on Fe3O4@SiO2-Graphene Oxide nanocomposites: A Strategy to Improve Catalytic Stability and Reusability in the Efficient Production of Phosphatidylserine
Authors: Shang Huiyi , Wang Juntan , Guo Bishan , Zhu Haihua , Li Huijuan
Published: January 2025

Phospholipase D (PLD) plays a pivotal role in the biosynthesis of phosphatidylserine (PS), but its practical application is constrained by limitations in stability and reusability. In this study, we successfully fabricated the Fe3O4@SiO2-graphene oxide (GO) nanocomposite by chemical binding of Fe3O4@SiO2 and GO. Subsequently, PLD was immobilized onto the nanocomposite via physical adsorption, with the aim of enhancing catalytic stability, reducing mass transfer resistance, and improving reusability. Under optimal conditions, the immobilization efficiency reached 84.4%, with a PLD loading capacity of 111.4 mg/gsupport. The optimal pH for PS production by immobilized PLD shifted from 6.0 to 6.5, while the optimal temperature increased from 45 °Cto 50 °C. Notably, the immobilized PLD demonstrated a shorter reaction time and a higher PS yield, achieving a 95.4% yield within 90 min, compared to the free PLD (78.1% yield within 150 min), representing a 1.04-fold improvement in production efficiency. Furthermore, the immobilized PLD exhibited outstanding storage stability and thermal stability, along with remarkable reusability. Even after being reused for 10 cycles, the PS yield still stays as high as 78.3%. These findings strongly suggest that the Fe3O4@SiO2-GO immobilized PLD has potential for the efficient production of PS.
TINJAUAN VARIABEL REFRIGERANT VOLUME
Authors: Rachman Arfidian , Yuana Dewi Arfita , Effendi Asnal , Nesti Lisa
Published: January 2025

Sistem VRV adalah sistem HVAC multi-split yang mempertahankan porsi berbeda dengan memvariasikan volume refrigeran. Sistem ini mengontrol volume zat pendingin/refrigeran untuk efisiensi dan keandalan. Kajian ini bertujuan untuk mengidentifikasi elemen sistem VRV yang mempengaruhi faktor operasional dan kinerja. Studi sebelumnya sangat penting untuk pengembangan VRV skala besar di masa depan.
ANALISIS KEBUTUHAN UAP PADA STASIUN STERILIZER DI PABRIK KELAPA SAWIT
Authors: Edi Siswanto Jatmiko , A Topan
Published: January 2025

Pada pengolahan kelapa sawit Salah satu proses adalah perebusan yang menggunakan peralatan mesin Steriliser, dimana Sterilizer adalah bejana uap yang digunakan untuk merebus TBS dengan tekanan uap sesuai dengan standart tekanan kerja yang diizinkan, begitu juga dalam Perebusan Tanda Kelapa Sawit dalam sterilizer mempunyai faktor faktor atau variable dalam perebusan yaitu Kapasitas Perebuasn (Q), Tekanan Perebusan (Peak pressure), Temperatur Air masuk (T.in) dan Waktu perebusan (t). untuk mengeahui optimalitas dalam proses perebusan dilakukan penelitian dan pengambilan data operasional Steriliser di industri Pabrik Kelapa Sawit didapat data data atau variable dalam perebusan. Dari perhitungan data penelitian didapat tekanan kerja perebusan akan mempengaruhi kebutuhan uap dalam proses dimana pada tekanan Peak 1 membutuhkan Uap sebesar 240.414 kkal/jam, Peak 2 membutuhkan Uap sebesar 705.819 kkal/jam Dan pada Peak 3 membutuhkan Uap sebesar 859.375 kkal/jam. Perebusan Optimal adalah kapasitas terbesar yang dihasilkan sesuai dengan tekanan kerja dalam hasil perebusan . yang optimal terlihat pada tekanan terbesar 2,7 Bar dengan waktu perebusan yang paling singkat yaitu sebesar 58 menit. Yang menghasilkan 9 rebusan per shift dengas kapasitas 207 Ton dan pada tekanan 2,4 Bar menghasilkan 8 rebusan per shif dengas kapasitas 84 Ton dan untuk tekanan 1,7 bar menghasilkan rebusan 7 per shift. dengas kapasitas 161 Ton.
PENGARUH PENAMBAHAN LIMBAH BATU BATA MERAH BUKITTINGGI SEBAGAI FILLER PADA CAMPURAN AC-WC DENGAN PENGUJIAN MARSHALL
Authors: Misbah Misbah , Pratiwi JF Anggun , Arman Arman , Mulyati Mulyati , Rofifah Jihan
Published: January 2025

Keberadaaan jalan raya sangat dibutuhkan dalam pengembangan suatu daerah. Permasalahan yang sering dihadapi dalam pembangunan jalan raya yakni muatan kendaraan berlebih dari yang diizinkan, pemeliharaan jalan yang kurang optimal serta pengaruh faktor campuran aspal, sehingga sering ditemukan jalan mengalami kerusakan sebelum umur rencana tercapai. Untuk meningkatkan kualitas konstruksi perkerasan jalan perlu dilakukan penelitian terhadap inovasi campuran yang digunakan atau memberikan bahan tambahan lain pada campuran konstruksi perkerasan tersebut, sehingga dihasilkan mutu campuran yang lebih baik. Jenis penelitian yang bisa dilakukan salah satunya adalah menggunakan metoda pembuatan benda uji dengan melakukan percobaan dilaboratorium dengan menganalisa pengaruh penambahan limbah batu bata merah Bukittinggi  sebagai filler pada campuran AC-WC dengan pengujian Marshall. Dari hasil penelitian dengan pengujian Marshall yang telah dilakukan, dengan judul “Pengaruh Penambahan Limbah Batu Bata Merah Bukittinggi  sebagai Filler pada campuran AC-WC dengan pengujian Marshall, didapat hasil pada penambahan variasi 1% filler limbah batu bata merah mengakibatkan nilai properties yaitu nilai : stabilitas, MQ, VMA, VFA memenuhi persyaratan spesifikasi Bina Marga 2018 revisi 2, sedangkan pada penambahan variasi 2% filler limbah batu bata merah mengakibatkan nilai properties yaitu nilai Flow dan VIM tidak memenuhi persyaratan spesifikasi Bina Marga 2018 rmevisi 2, hal ini menandakan meningkatnya deformasi pada lapis perkerasan saat diberikan beban. Maka, pada variasi penambahan 2% tidak dianjurkan, penggunaan limbah batu bata merah sebagai filler added pada campuran AC-WC yang dapat digunakan hanya sampai batas 1%.
Modeling of Multiphase Flow with the Wellbore in Gas-Condensate Reservoirs Under High Gas/Liquid Ratio Conditions and Field Application
Authors: Hong Jiajun , Wang Zhihua , Wang Cong , Zhang Jiuxiang , Liu Wenbo , Ling Kegang
Published: January 2025

Due to the deeper burial depths of gas-condensate reservoirs, temperatures and pressures are much higher than in conventional reservoirs, resulting in the wellbore usually having a high gas/liquid ratio. The retrograde condensation phenomenon is often observed during the production process of such gas-condensate wellbores. Especially when heavy components are present in the gas-condensate wellbore, the appearance of wax particles occurs, and complex multiphase flow characteristics, with gas, liquid, and solid phases mixed flow, are formed. This leads to a serious threat to the safety and production within the wellbore in the gas-condensate reservoir under a high gas/liquid ratio, and even wellbore region blockage. The wax appearance and dynamic changes caused by retrograde condensation are fully considered in this study; through coupling the multiphase flow characteristics of a gas-condensate wellbore with the phase transition process, a mathematical model was established to predict multiphase flow in a gas-condensate wellbore. This model reveals the phase behaviors and wax appearance characteristics within the wellbore in the gas-condensate reservoir under a high gas/liquid ratio. As the wellbore depth decreases, phase changes occur in sequence with decreasing molecular weight, appearing in liquid and solid phases. The wax particles of the solid phase are mainly composed of C33* (C33–C40) and C25* (C25–C32), while the liquid phase formed by the retrograde condensation is primarily composed of C17* (C17–C24) and C9* (C9–C16). In addition, it establishes a general correlation between pressure drop, temperature drop, and wellbore depth in high gas/liquid ratio condensate wellbores, and the model’s error is controlled within a 5% range by validating with actual data. Finally, the model calculation results determined the flow pattern transition process as follows: From single-phase gas flow at the bottomhole to gas-liquid phases mist flow and gas-liquid-solid phases mist flow toward the wellhead, and in conjunction with the supercritical state of light hydrocarbons to provide an explanation for change characteristics of pressure drop at the transition boundary between different flow patterns.
Water-Alternating-Gas Performance in Highly Heterogeneous Carbonates: Simulation Study Applied to Cross Sections of Brazil Pre-Salt Fields
Authors: Kahrobaei Siavash , Lamine Sadok , Groenenboom Jeroen , van Batenburg Diederik
Published: January 2025

A significant part of the production and associated reserves in the pre-salt cluster of the Santos Basin, offshore Brazil, comes from lacustrine carbonates that are deposited in successive horizontally extensive cyclothems that show strong vertical fine-scale variations with a Dykstra-Parsons (DP) coefficient larger than 0.95. The fields are developed with miscible gas injection (GI) and water-alternating-gas (WAG) injection almost from the start. In this paper, we build fine-scale cross-sectional models that honor the vertical small-scale permeability distribution observed in core measurements to quantify the interplay between pressure/volume/temperature, viscous, and gravity forces that are at play during gas and/or WAG injection.

For high heterogeneity levels representative of the cyclothem areas, the predicted gas/liquid ratio (GLR) and water cut exhibit cyclic behavior following the water injection (WI) and GI cycles. Similar behavior is observed in the field for the areas with high heterogeneity cyclothems. Under these conditions, the flow is essentially viscous-dominated as the strong vertical permeability contrasts are effectively resulting in low vertical permeability. For lower heterogeneity levels, the gravity forces become more dominant resulting in gas override with high GLR without clear cyclic behavior.

Furthermore, the effects of operating pressure, relative permeability hysteresis, gas trapping, and start time for the first gas slug on predicted oil recovery were evaluated. Including gas trapping and hysteresis improves the recovery but dampens the cyclic behavior. For the more heterogeneous models, the predictions show that it is beneficial to start the first gas cycle of the WAG injection early.
Representation of prime numbers on the complex plane
Authors: Csóka Levente
Published: January 2025

This study proposes a novel representation of prime numbers implying a quasiperiodic pattern within their distribution. Based on the result that any real number, and consequently, a prime number, can be represented in a complex plane using Euler’s notation; we investigated the quantities characterizing the sum of centres, which were observed as prime numbers. The numerical results indicate that prime numbers can be generated by rooting the real numbers, and their progression can be decomposed into periodic sequences. Within this framework, a harmonic prime function was identified, offering new insights into the structural intricacies of prime number sequences. The methodology employed advanced techniques to uncover the hidden periodicity underlying the quasiperiodic arithmetic progressions of primes, shedding light on the deeper patterns governing their distribution.
GNSS signal multi-frequency carrier phase asynchronous joint tracking
Authors: Wang Dun , Liu Peng , Peng Bo , Liu Tong , Chen Yaohui , Zhang Shuangna , Dong Qijia
Published: January 2025

As demonstrated in numerous studies, jointly tracking global navigation satellite system (GNSS) multi-frequency signals transmitted from the same satellite can improve tracking sensitivity and robustness. To facilitate the application of this joint tracking technique in contemporary GNSS receivers with asynchronous signal reception structures, we propose a synchronous-input asynchronous-update mechanism for multi-frequency carrier phase joint tracking. To elucidate the joint-tracking mechanisms, a linearized mathematical model of the joint tracking loop is constructed. We derive an equation to calculate the thermal noise jitter of the loop. Additionally, we examine the dynamic stress response characteristics of the loop and clarify the loop design requirements for eliminating the influence of inter-frequency biases. The theoretical results are validated using Monte Carlo simulations and preliminary field tests, with the B1C and B2a pilot signals from the medium earth orbit (MEO) satellite within the BeiDou satellite navigation system (BDS). Experimental results show that the carrier phase tracking threshold of the B1C and B2a signals can be reduced by approximately 1 dB and 3.5 dB, respectively.
WITHDRAWN: Configuration Paths for High-Quality Development of Listed Companies Basedon the TOE Framework: Evidence from China's high- and new-technologyenterprises
Authors: Qian Min , Yang Jiameng
Published: January 2025

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
WITHDRAWN: Mitigating Strength Loss in Mortar Due to Casting Delays: Quantified Impact of Additional Water and Cement
Authors: Mahzuz H. M.A. , Former Imran Hossain , Lizon Nasir Uddin Ahammed , Nury Ahmad Hasan
Published: January 2025

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
A spatiotemporal atlas of human spermatogenesis
Authors: Lindskog Cecilia , Hikmet Feria , Méar Loren , Gustavsson Jonas , Miranda Gisele , Zhang Cheng , Katona Borbala , Schutten Rutger , von Feilitzen Kalle , Forsberg Mattias , Stukenborg Jan-Bernd , Uhlén Mathias
Published: January 2025

Human health depends on complex processes of intercellular interactions and single-cell type-specific functions. Here, we demonstrate that the integration of data from single-cell RNA sequencing (scRNA-seq) with fluorescent-based multiplex immunohistochemistry (mIHC) is a powerful strategy for large-scale spatiotemporal mapping of single cells in a tissue-specific context. We focused on the landscape of 12 distinct germ cell states in adult human testes and performed an in-depth characterization of ~ 500 proteins. Quantitative spatial localization data based on a custom-built image analysis pipeline allowed us to cluster proteins according to expression, forming the basis for functional analysis. Protein and mRNA expression dynamics showed multiple cases with low levels of co-expression in the same cell state, with proteins being expressed in later states in comparison to mRNA. This highlights the necessity of studying protein levels in single-cell mapping projects. The presented workflow holds promise for proteome-wide tissue studies in health and disease.
Ferroptosis in Neurons: A Bibliometric Analysis of Research Trends, Key Contributions, and Emerging Directions
Authors: Sun Shanshan , Wang Qiuxuan , Zhang Ziyi , Huang Jingjie , Huang Yue , Han Jingxian , Du Yuanhao , Zhang Xuezhu
Published: January 2025

Background
Neurons are the fundamental structural and functional units of the nervous system, serving as the core cells for information transmission and regulation. They are closely associated with various neurological diseases. Recent studies have shown significant advancements in research on ferroptosis in neurons; however, there has been a lack of bibliometric analysis in this field. This study aims to provide a comprehensive overview of the knowledge structure related to ferroptosis in neurons through bibliometric methods, identify current research trends and hotspots, and predict potential future research directions.
Methods
We conducted a search for publications related to ferroptosis in neurons from 2014 to 2024 in the Web of Science Core Collection (WoSCC) database. Bibliometric methods were employed to analyze authors, institutions, countries, journals, and references using VOSviewer, CiteSpace, and the R package "bibliometrix".
Results
This study included 685 articles from 50 countries, with China and the United States being the leading contributors. The number of publications related to ferroptosis in neurons has shown a year-on-year increase. The primary research institutions are Central South University, Harbin Medical University, and the University of Melbourne. Free Radical Biology and Medicine is the most popular journal in the field, while Cell has the highest citation count. A total of 4,673 authors contributed to the research, with David Devos and Ashley I. Bush having the highest number of publications, while Scott J. Dixon had the most co-citations. Keyword analysis revealed that the fundamental molecular mechanisms of ferroptosis and its application in neurological diseases are the primary research focuses in this field.
Conclusion
This study is the first comprehensive bibliometric analysis summarizing the trends and developments in ferroptosis research in neurons. The study outlines and predicts global research hotspots and trends, providing valuable references for scholars studying ferroptosis.
C-reactive protein dissociation contributes to choroidal neovascularization in vivo: implications for age-related macular degeneration
Authors: Hernandez Maria , Romero-Vazquez Sara , Recalde Sergio , Bezunartea Jaione , Moreno-Orduña Maite , Belza-Zuazu Idoia , Garcia-Layana Alfredo , Adan Alfredo , Fernandez-Robredo Patricia , Molins Blanca
Published: January 2025

Choroidal neovascularization (CNV) and inflammation processes play an important role in retinal disease development and C-reactive protein (CRP) has been shown to contribute to development diseases like Age-related macular degeneration (AMD). Our aim was to evaluate whether monomeric and pentameric CRP (pCRP, mCRP) isoforms contribute to CNV in vivo and to characterize the mechanism of CRP dissociation in-vivo and in vitro. Both CRP isoforms were intravitreally (IVT) or intravenously (IV) injected in mice, CNV was laser-induced, retinography and fluorescein angiography were performed to evaluate edema. Lectin, mCRP, F4/80 and C5b9 localization were assessed by immunofluorescence and visualized under a confocal microscope. Intensity of fluorescence of mCRP (IF mCRP) was also quantified. To confirm pCRP dissociation in ARPE-19 cells and mice, pCRP was coupled to a fluorochrome and IVT injected. A statistical increase in CNV areas was observed in pCRP IVT injected males (p<0.05) while a statistical decrease was shown in females (p<0.05). After IV injection, pCRP males showed an increase in CNV areas only vs. mCRP injected mice (p<0.05) and in females the injection of pCRP injected mice showed higher CNV areas vs. vehicle (p<0.05) and vs. mCRP injected mice (p<0.05). Retinal edema after IVT CRP injection was observed mainly in mCRP injected mice. In females there was an IF mCRP statistical decrease in pCRP IVT injected mice vs. vehicle and a statistical increase in pCRP IV injected mice vs. vehicle (p<0.05). Mice injected with IVT isoforms showed F4/80 positive cells and C5b-9 deposition around the CNV areas. mCRP labeling was observed in the intercellular space of the endothelial cells in the angiogenic area and detected in pCRP IVT injected animals, demonstrating the dissociation of pCRP into mCRP both in vitro and in vivo in proinflammatory microenvironments. In conclusion, CRP administration increased CNV areas and edema in the retina, suggesting that CRP is activated in the CNV inflammatory environment. Additionally, pCRP dissociates in vivo into mCRP close to CNV damaged tissue, hypothesizing that mCRP is the CRP conformation that contributes to the exacerbation of the CNV process.
Piloting An Oral Health Training Program for Diabetes Educators in Australia
Authors: George Ajesh , Kong Ariana , Poudel Prakash , Arora Amit , Lau Phyllis , Griffiths Rhonda , Masoe Angela , Sofronoff Susanne , Martin Rachel E , Akerman Lorena , Wong Jennifer , Uthurralt Natalia , Priede Andre , Wong Vincent , Forsyth Cathryn , Marwaha Parul , Kezhekkekara Shwetha , Calache Hanny
Published: January 2025

Aims: To develop and pilot a diabetes oral health training program to assess its effectiveness in improving oral health knowledge and confidence of diabetes educators (DEs), and the acceptability, feasibility, and sustainability of integrating the training into practice.
Methods: A sequential mixed-methods design followed the development of an online three-module training program, which integrated videos, a screening tool, and resources to support oral health referrals. A pre-post knowledge and confidence questionnaire was analysed using a paired-sample t-test. Qualitative semi-structured interviews were recorded, transcribed and analysed using inductive thematic analysis.
Results: Twenty-one DEs from the states of New South Wales and Victoria participated. There was an overall significant difference in the knowledge scores pre-test (mean = 23.24, SD 4.4) compared to post-test (mean = 29.67, SD 2.01), (t=-6.11), p<0.001), and across all confidence variables on discussing, screening and referring clients to oral health services. Most participants agreed with the trainings perceived acceptability, feasibility, and sustainability, although some recommendations were made to improve long-term sustainability.
Conclusions: The results showed that using online training modules and tailored resources to support clinical practice effectively improved oral health knowledge and confidence in DEs and was acceptable, feasible, and sustainable for integration into clinical practice.
The Soil Microbiome of the Caatinga Drylands in Brazil
Authors: Rech Elibio , Tacca Luísa , Lima Rayane , de Oliveira Marco , Pascoal Patrícia , Bambil Deborah , Rosinha Grácia , Signor Diana , Freire Marcelo
Published: January 2025

Drylands represent a significant part of the Earth's surface and include essential and vulnerable ecosystems for the global ecological balance. The Caatinga, with its unique biodiversity adapted to the extreme conditions of this semi-arid region, offers a valuable opportunity to expand our knowledge about these ecosystems. Here, this work reveals the high microbial diversity in the soil and rhizosphere of the Caatinga, with the roots presenting more specialized communities. Bacteria such as Bacilli, Alphaproteobacteria and Firmicutesexcelled in critical functions such as nutrient cycling. Interplant differences suggested the influence of root exudates. The metagenomic study of interactions between microorganisms in the rhizosphere of selected plants revealed microbial biodiversity and contributed to our understanding of nutrient cycling, plant growth and resistance to water stress. In addition, they demonstrate biotechnological potential to address global challenges such as desertification and food security.
Assessing Parental Knowledge, Attitudes, and Practices Towards Antibiotic Use in Children: A Study in a teaching and training Tertiary Care Hospital in Mogadishu, Somalia
Authors: İsse Suad Abdikarim , DOĞAN Ahmet , Çelik Ali kutta , Ali Tigad Abdisad , Wehlie Jabir Abdullahi , Sheikh Sowda Abdikarim , TURKAN Mucahit , Ali Bisharo Omar , Ahmed Qasim shirar , Ali Ahmed Mohamed , Isse salma Abdikarim , Hilowle Fartun Mohamed
Published: January 2025

Background
The inappropriate use of antibiotics in children remains a global concern, contributing to antibiotic resistance. This study aims to assess parents' knowledge, attitudes, and practices regarding antibiotic use in children at a tertiary care hospital in Mogadishu, Somalia.
Methods
A cross-sectional descriptive study was conducted at Mogadishu-Somalia-Turkey Recep Tayyip Erdoğan Training and Research Hospital with 325 parent participants.
Results
14.5% of parents knew antibiotics treat bacterial infections, while 35.1% believed antibiotics could treat viral infections. 64.3% thought antibiotics could be used for colds. 57.8% recognized penicillin as an antibiotic. 78.8% were aware of allergy risks, but 60.6% reported stopping antibiotics when their child felt better.
Conclusion
Significant gaps in parental knowledge and misconceptions about antibiotics were identified. Targeted educational programs are crucial to enhance awareness and promote responsible antibiotic use.