bluuebunny/crossref_metadata_2025 huggingface dataset:
Measurement of lactate levels in postmortem brain, iPSCs, and animal models of schizophrenia
Authors: Sullivan Courtney R. , Mielnik Catharine A. , Funk Adam , O’Donovan Sinead M. , Bentea Eduard , Pletnikov Mikhail , Ramsey Amy J. , Wen Zhexing , Rowland Laura M. , McCullumsmith Robert E.
Published: March 2019

Converging evidence suggests bioenergetic defects contribute to the pathophysiology of schizophrenia and may underlie cognitive dysfunction. The transport and metabolism of lactate energetically couples astrocytes and neurons and supports brain bioenergetics. We examined the concentration of lactate in postmortem brain (dorsolateral prefrontal cortex) in subjects with schizophrenia, in two animal models of schizophrenia, the GluN1 knockdown mouse model and mutant disrupted in schizophrenia 1 (DISC1) mouse model, as well as inducible pluripotent stem cells (iPSCs) from a schizophrenia subject with the DISC1 mutation. We found increased lactate in the dorsolateral prefrontal cortex (p = 0.043, n = 16/group) in schizophrenia, as well as in frontal cortical neurons differentiated from a subject with schizophrenia with the DISC1 mutation (p = 0.032). We also found a decrease in lactate in mice with induced expression of mutant human DISC1 specifically in astrocytes (p = 0.049). These results build upon the body of evidence supporting bioenergetic dysfunction in schizophrenia, and suggests changes in lactate are a key feature of this often devastating severe mental illness.
A Genome-Wide Analysis of the Penumbral Volume in Inbred Mice following Middle Cerebral Artery Occlusion
Authors: Rudy Robert F. , Charoenvimolphan Nareerat , Qian Baogang , Berndt Annerose , Friedlander Robert M. , Weiss Scott T. , Du Rose
Published: March 2019

Following ischemic stroke, the penumbra, at-risk neural tissue surrounding the core infarct, survives for a variable period of time before progressing to infarction. We investigated genetic determinants of the size of penumbra in mice subjected to middle cerebral artery occlusion (MCAO) using a genome-wide approach. 449 male mice from 33 inbred strains underwent MCAO for 6 hours (215 mice) or 24 hours (234 mice). A genome-wide association study using genetic data from the Mouse HapMap project was performed to examine the effects of genetic variants on the penumbra ratio, defined as the ratio of the infarct volume after 6 hours to the infarct volume after 24 hours of MCAO. Efficient mixed model analysis was used to account for strain interrelatedness. Penumbra ratio differed significantly by strain (F = 2.7, P < 0.001) and was associated with 18 significant SNPs, including 6 protein coding genes. We have identified 6 candidate genes for penumbra ratio: Clint1, Nbea, Smtnl2, Rin3, Dclk1, and Slc24a4.
On the stress-strain alignment in premixed turbulent flames
Authors: Ahmed Umair , Chakraborty Nilanjan , Klein Markus
Published: March 2019

The interaction of large and small scale structures is fundamental to the energy cascade in turbulent flows. The correct representation of this interaction becomes important in the context of large eddy simulation (LES), where the response of small-scale structures to the resolved quantities, or large-scale structures, must be parametrised. This challenging task becomes more demanding when LES of premixed flames are considered, as heat release affects the interaction of turbulence and chemistry occurring at the unresolved scales. In this work, the influence of sub-grid scale (SGS) stresses on the kinetic energy budget of the resolved velocity field in turbulent premixed flames is investigated. In this spirit, the alignment between the SGS stresses and the resolved strain rate has been analysed by interrogating a direct numerical simulation (DNS) database of statistically planar premixed flames subjected to forced isotropic turbulence. It has been found that the alignment between the eigenvectors of the SGS stresses and the resolved strain rate changes across the flame brush and this change is dependent on the level of turbulence experienced by the flame. The influence of different turbulence intensities and different filter widths along with the implications of this misalignment on the SGS modelling are discussed in detail in the paper.
Genome-wide Analysis Reveals DNA Methylation Alterations in Obesity Associated with High Risk of Colorectal Cancer
Authors: Dong Lixin , Ma Li , Ma Gloria H. , Ren Hongmei
Published: March 2019

Obesity is a high risk factor for colorectal cancer (CRC). The contribution of underlying epigenetic mechanisms to CRC and the precise targets of epigenetic alterations during cancer development are largely unknown. Several types of epigenetic processes have been described, including DNA methylation, histone modification, and microRNA expression. To investigate the relationship between obesity and CRC, we studied both obese and CRC patients, focusing on genome-wide peripheral blood DNA methylation alterations. Our results show abnormal distributions of overlapping differentially methylated regions (DMRs) such as hypermethylated CpG islands, which may account for epigenetic instability driving cancer initiation in obesity patients. Furthermore, functional analysis suggests that altered DNA methylation of extracellular (e.g., O-glycan processing) and intracellular components contribute to activation of oncogenes (e.g. KRAS and SCL2A1) and suppression of tumor suppressors (e.g. ARHGEF4, EPHB2 and SOCS3), leading to increased oncogenic potency. Our study demonstrates how DNA methylation changes in obesity contribute to CRC development, providing direct evidence of an association between obesity and CRC. It also reveals the diagnostic potential of using DNA methylation as an early risk evaluation to detect patients with high risk for CRC.
The influence of a single hemodialysis procedure on human T lymphocytes
Authors: Lisowska Katarzyna A. , Pindel Małgorzata , Pietruczuk Krzysztof , Kuźmiuk-Glembin Izabella , Storoniak Hanna , Dębska-Ślizień Alicja , Witkowski Jacek M.
Published: March 2019

At the moment it is unknown to what extent the impaired function of T lymphocytes in ESRD patients depends on uremia, and to what extent on hemodialysis (HD) procedure. Therefore, the purpose of the study was to evaluate percentages of T lymphocyte subpopulations ex vivo, plasma concentrations of IL12p70, TNF, IL-10, IL-6, IL-1β, IL-8 cytokines and selected proliferation parameters of in vitro activated T lymphocytes in HD patients before and after single HD procedure using flow cytometry. We demonstrated that the percentage of CD8+ cells ex vivo was decreased while the CD4+/CD8+ ratio was increased after HD procedure. Also, there was significant decrease in the percentage of CD8+HLA-DR+, CD8+CD69+ and CD8+CD95+ cells after HD. At the same time, an increase in the percentage of CD4+CD95+ cells was observed after HD. From all analyzed cytokines, only the concentration of IL-8 was significantly decreased after HD procedure. A single HD session enhanced proliferation capacity of CD4+ cells but not CD8+ cells in vitro by increasing number of cell divisions and percentage of dividing cells. Our results show that a single hemodialysis can have immunomodulatory effect on HD patients and may contribute to the state of immune deficiency observed in patients with ESRD.
Risk factors associated with locoregional failure and estimation of survival after curative resection for patients with distal bile duct cancer
Authors: Im Jung Ho , Park Joon Seong , Yoon Dong Sup , Lee Dong Ki , Kim Jun Won , Lee Ik Jae
Published: March 2019

Our aim was to identify the risk factors associated with locoregional recurrence in resected distal bile duct cancer (DBDC), and to determine the subgroup that may benefit from adjuvant radiotherapy. Between 2001 and 2013, we retrospectively analyzed 93 patients with DBDC who had undergone curative resection. Patients who received adjuvant radiotherapy were excluded. The 3-year locoregional failure-free survival (LRFFS) and overall survival (OS) rates for all patients were 50.7%, and 53.2%, respectively. On multivariate analysis, the preoperative carcinoembryonic antigen (CEA) level, resection margin, histologic grade, T stage, and N stage were significant prognostic factors for LRFFS. Locoregional recurrence was observed in more than 78% of the patients who underwent R1 resection and were node-positive, and the 3-year LRFFS rate was 19.3%. The 3-year LRFFS rate was 46.9% in the patients who underwent R0 resection and were node-negative with more than 2 risk factors (preoperative CEA level ≥ 5 ng/mL, poorly differentiated histologic grade, and T3 stage). On multivariate analysis for OS, patients with more than 2 risk factors showed a 7-fold higher risk of death, compared with patients with 1 or no risk factor. The important risk factors of locoregional failure in patients with DBDC who underwent resection were R1 resection and positive lymph nodes. Adjuvant radiotherapy should be considered for these patients to improve the oncologic outcomes. Patients undergoing selective R0 resection and those with node-negative status and multiple locoregional failure risk factors may benefit from adjuvant radiotherapy.
Genetic polymorphisms in MTR are associated with non-syndromic congenital heart disease from a family-based case-control study in the Chinese population
Authors: Deng Changfei , Deng Ying , Xie Liang , Yu Li , Liu Lijun , Liu Hanmin , Dai Li
Published: March 2019

Genetic polymorphisms of folate pathway genes have been reported to be associated with congenital heart diseases (CHDs); however, the results remain conflicting. We conducted a family-based case-control study, which included160 CHD case-parent triads and 208 control-parent triads to explore the association of 18 genetic variants of seven folate metabolism-related genes with the risk of CHDs. The MTR C allele of rs1770449 (OR = 1.961, 95%CI: 1.379–2.788) and the MTR A allele of rs1050993 (OR = 1.994, 95%CI: 1.401–2.839) in infants were associated with an increased risk of CHDs. Over-transmission of SNPs rs1770449 and rs1050993 and haplotype CAA (rs1770449-rs1805087-rs1050993) in MTR were detected in total CHDs. The above mentioned associations of MTR with CHDs were also observed in septal defects and conotruncal heart defects subgroups. Without maternal periconceptional folate intake, the risk of CHDs among women carrying the rs1770449 “CT or CC” genotype or the rs1050993 “AG or AA” genotype in MTR was 3.262(95%CI: 1.656–6.429) or 3.263(95%CI: 1.656–6.429) times greater than the aOR in women carrying wild genotype, respectively. Our study suggests that MTR polymorphisms (rs1770449 and rs1050993) may be associated with the risk of CHDs and modify the relation between maternal folate intake and CHDs.
Crosssectional Assessment of Bone Mass Density in Adults with Hepatitis B Virus and Hepatitis C Virus Infection
Authors: Chen Yuan-Yuei , Fang Wen-Hui , Wang Chung-Ching , Kao Tung-Wei , Chang Yaw-Wen , Yang Hui-Fang , Wu Chen-Jung , Sun Yu-Shan , Chen Wei-Liang
Published: March 2019

Osteoporosis is one of the major complications in chronic hepatitis B virus (HBV) and hepatitis C (HCV) infection. However, few studies had examined the relationship between hepatic viral infection with bone loss. Our aim was to investigate the association between hepatic viral infection with bone mineral density (BMD) in a cross-sectional study. Participants who attended the health examinations at the Tri-Service General Hospital (TSGH), Taiwan, were enrolled in the study. Diagnosis of viral hepatitis was confirmed by the serum viral markers of hepatitis B surface antigen (HBsAg) and anti-HCV, and BMD measurement was performed by the bone densitometry. Subjects were divided into four groups by the presence of viral markers. The association between hepatic viral infection and BMD was examined by a multivariate linear regression model. HBV infection was inversely associated with BMD after full adjusting withβvalues of −0.17 (95% CI: −0.29, −0.05) (p < 0.05). The relationship remained significant in males (β = −0.16, 95% CI = −0.31, −0.01) (p < 0.05). In subjects with body mass index less than 30 HBV infection was associated with reduced BMD (β = −0.16, 95% CI = −0.29, −0.02) (p < 0.05). However, HCV infection was only associated with an increase in BMD in patients with BMI less than 30 (β = 0.17, 95% CI = 0.21, 0.32) (p < 0.05). Chronic HBV infection was significantly associated with reduced BMD in males. The impact of viral hepatitis on bone health deserves further investigation for the potential pathophysiological mechanisms.
Genospecies of Borrelia burgdorferi sensu lato detected in 16 mammal species and questing ticks from northern Europe
Authors: Mysterud Atle , Stigum Vetle M. , Jaarsma Ryanne I. , Sprong Hein
Published: March 2019

Lyme borreliosis is the most common vector-borne zoonosis in the northern hemisphere, and the pathogens causing Lyme borreliosis have distinct, incompletely described transmission cycles involving multiple host groups. The mammal community in Fennoscandia differs from continental Europe, and we have limited data on potential competent and incompetent hosts of the different genospecies of Borrelia burgdorferi sensu lato (sl) at the northern distribution ranges where Lyme borreliosis is emerging. We used qPCR to determine presence of B. burgdorferi sl in tissue samples (ear) from 16 mammalian species and questing ticks from Norway, and we sequenced the 5S–23 S rDNA intergenic spacer region to determine genospecies from 1449 qPCR-positive isolates obtaining 423 sequences. All infections coming from small rodents and shrews were linked to the genospecies B. afzelii, while B. burgdorferi sensu stricto (ss) was only found in red squirrels (Sciurus vulgaris). Red squirrels were also infected with B. afzelii and B. garinii. There was no evidence of B. burgdorferi sl infection in moose (Alces alces), red deer (Cervus elaphus) or roe deer (Capreolus capreolus), confirming the role of cervids as incompetent hosts. In infected questing ticks in the two western counties, B. afzelii (67% and 75%) dominated over B. garinii (27% and 21%) and with only a few recorded B. burgdorferi ss and B. valaisiana. B. burgdorferi ss were more common in adult ticks than in nymphs, consistent with a reservoir in squirrels. Our study identifies potential competent hosts for the different genospecies, which is key to understand transmission cycles at high latitudes of Europe.
Phosphines: preparation, reactivity and applications
Authors: Musina E. I. , Balueva A. S. , Karasik A. A.
Published: March 2019

The annual survey of the literature relating to the chemistry of traditional phosphines containing only P–C and P–H bonds published during 2017 is presented. It includes the the synthesis of new phosphines classified according to the used synthetic approachs, the data concerning the reactivity of phosphines excluding metal complexation (mainly the attack of phosphorus at carbon or other atoms and the formation of P(v) derivatives of phosphines) and the application of phosphines in organocatalysis and other fields of chemistry or adjacent sciences.
Phosphonium salts and P-ylides
Authors: Selva M. , Perosa A. , Fiorani G.
Published: March 2019

The present review collects and describes the literature on preparation, characterisation and applications of phosphonium salts and ylides, covering the timeframe between January and December 2017. The large number of reviewed references highlights the importance of these P-based derivatives in synthetic and non-synthetic applications. For the Reader's convenience, topics are organized to offer an introductory survey on the methods of preparation and characterisation of both types of compounds, followed by an analysis of applicative and curiosity driven research. Recent advances on synthesis and applications of phosphonium-based ionic liquids (PILs) are summarised in a dedicated section.
Nucleotides and nucleic acids: mononucleotides
Authors: Guga Piotr , Maciaszek Anna D. , Radzikowska Ewa
Published: March 2019

This chapter covers selected papers published in the years 2016 and 2017 on chemical synthesis and biological application of nucleotides and their analogues, including data on related prodrugs (mostly exerting antiviral properties) and specific and highly sensitive probes for detection of biomolecules important for elucidation of biochemical processes. Whereas the commonly known nucleotides (i.e. nucleosides bearing a phosphate group) are mostly the building blocks of DNA or RNA, there is a growing field of less recognised nucleotide and nucleotide-like molecules playing specific signalling or regulatory roles, and their analogues are designed and used for investigation or tuning of biochemical pathways, both in vitro and in vivo. The progress in chemistry of nucleic acids components responds to those needs, and chemists and biochemists provide compounds using either purely chemical or combined chemo-enzymatic approaches. It should be emphasised that all those efforts are greatly supported by enormous development of analytical methods, which allow for fast and precise detection of investigated complexes or metabolites.
Phosphazenes
Authors: Chandrasekhar Vadapalli , Chakraborty Amit
Published: March 2019

This chapter describes the advances in the chemistry of phosphazenes in the year 2017. The topics include acyclic phosphazenes, cyclophosphazenes and polyphosphazenes. The synthesis, structure, reactivity and applications of these compounds are discussed. Studies on acyclic phosphazenes include their applications as super bases and as ligands to transition metal and lanthanide complexes and the utility of the latter as catalysts. The coverage on cyclophosphazenes includes structure and bonding and the utility of these compounds to function as supports for the preparation of star-like compounds. Polyphosphazenes and related hybrid polymers are attracting considerable interest in biological applications including as bio-erodible and bio-inert polymers. In addition many of these polymers are also being used as flame retardant agents and as electrolyte materials.
Green synthetic approaches in organophosphorus chemistry: recent developments
Authors: Brahmachari Goutam
Published: March 2019

Organophosphorus chemistry is a very broad and exciting field, with potential opportunities to researchers involved in multi-disciplinary areas of scientific endeavour including organic, medicinal, pharmaceutical, agricultural and industrial chemistry. Organophosphorus compounds find extensive applications in all these fields owing to their inherent physical and biological properties. Since its first development in the 90s, the topic of green and sustainable chemistry has now attained a considerable growth over the past twenty five years and has become much more popular among the researchers working in all branches of chemical science. As part of these noteworthy developments, synthetic organic chemists have also been motivated to develop eco-friendly methodologies for generating phosphorus-functionalized compounds of potential interest, focusing on various aspects of green chemistry principles, and as a result considerable progress towards green and sustainable chemistry has been accomplished during the last decade. In continuation of our earlier contributions, this present chapter is also aimed to offer an overview of such developments in the field of green synthetic approaches in organophosphorus chemistry reported during the year 2017.
Long-range ferromagnetism in nickel-based hybrid structure with semiconductor behavior
Authors: Mani Prabu , Bandyopadhyay Arkamita , Mukharjee Prashanta K. , Nath Ramesh Chandra , Pati Swapan K. , Mandal Sukhendu
Published: March 2019

A new three-dimensional nickel-based hybrid structure exhibits semiconductor and long-range ferromagnetic behaviour.
The origin of the unusual DSC peaks of supercooled barium disilicate liquid
Authors: Moulton Benjamin J. A. , Rodrigues Alisson M. , Sampaio David V. , Silva Laís D. , Cunha Thiago R. , Zanotto Edgar D. , Pizani Paulo S.
Published: March 2019

Crystallization proceeds through high-temperature and non-stoichiometric phases which recrystallize to become sanbornite (BaSi2O5) during heating or through time.
Experimental and computational studies on ruthenium(ii) bis-diimine complexes of N,N′-chelate ligands: the origin of changes in absorption spectra upon oxidation and reduction
Authors: Tan Siew San , Yanagisawa Susumu , Inagaki Kouji , Kassim Mohammad B. , Morikawa Yoshitada
Published: March 2019

The first report seeking to determine the origin of the observed spectral changes by investigating the frontier MOs and electronic structures of the ligands.
Ab initio prediction of structuring/mesoscale inhomogeneities in surfactant-free microemulsions and hydrogen-bonding-free microemulsions
Authors: Hahn Maximilian , Krickl Sebastian , Buchecker Thomas , Jošt Gašper , Touraud Didier , Bauduin Pierre , Pfitzner Arno , Klamt Andreas , Kunz Werner
Published: March 2019

Prediction of microemulsion-like structuring in surfactant-free and hydrogen-bonding-free systems.
In situ XAS study of the local structure and oxidation state evolution of palladium in a reduced graphene oxide supported Pd(ii) carbene complex during an undirected C–H acetoxylation reaction
Authors: Yuan Ning , Majeed Maitham H. , Bajnóczi Éva G. , Persson Axel R. , Wallenberg L. Reine , Inge A. Ken , Heidenreich Niclas , Stock Norbert , Zou Xiaodong , Wendt Ola F. , Persson Ingmar
Published: March 2019

In situ XAS is used to reveal the evolution of palladium species during an undirected C–H acetoxylation reaction.
Verifying the olefin formation mechanism of the methanol-to-hydrocarbons reaction over H-ZSM-48
Authors: Zhang Jie , Huang Zhihua , Xu Lanjian , Zhang Xiaomin , Zhang Xinzhi , Yuan Yangyang , Xu Lei
Published: March 2019

The product distributions and catalytic cycle of the methanol-to-hydrocarbons reaction over H-ZSM-48 zeolite can be altered by changing the reaction temperature.
Exploring co-occurrence patterns between organic micropollutants and bacterial community structure in a mixed-use watershed
Authors: Gao Han , LaVergne Jeanne M. , Carpenter Corey M. G. , Desai Raj , Zhang Xu , Gray Kimberly , Helbling Damian E. , Wells George F.
Published: March 2019

Complex mixtures of low concentrations of organic micropollutants were quantified for inputs and surface water samples along a reach of the Des Plaines River; coupled with bacterial community analysis, these results document a significant link between the complex micropollutant mixtures and associated bacterial community structure.
Turning the challenge of quantum biology on its head: biological control of quantum optical systems
Authors: Lishchuk Anna , Vasilev Cvetelin , Johnson Matthew P. , Hunter C. Neil , Törmä Päivi , Leggett Graham J.
Published: March 2019

Strong coupling between plasmon modes and chlorins in synthetic light-harvesting maquette proteins yields hybrid light-matter states (plexcitons) whose energies are controlled by design of protein structure, enabling the creation of new states not seen under weak coupling.
Metallomicelle catalyzed aerobic tandem desilylation/Glaser reaction in water
Authors: Tang Shanyu , Li Longjia , Ren Xuanhe , Li Jiao , Yang Guanyu , Li Heng , Yuan Bingxin
Published: March 2019

The copper complexes of PEG-grafted nitrogen ligands serve as metallomicellar nanoreactors for the aerobic tandem desilylation/Glaser coupling of TMS-protected alkynes in water.
Synthesis, characterization and properties of a novel energetic ionic salt: dicarbohydrazide bis[3-(5-nitroimino-1,2,4-triazole)]
Authors: Ren Jianrong , Chen Dong , Fan Guijuan , Xiong Ying , Zhang Zhenqi , Yu Yanwu , Li Hongzhen
Published: March 2019

DCBNT, a new compound, exhibits low friction and impact sensitivities, good thermal stability, and promising detonation pressure and detonation velocity.
Potent α-amylase inhibitory activity of sprouted quinoa-based yoghurt beverages fermented with selected anti-diabetic strains of lactic acid bacteria
Authors: Ujiroghene Obaroakpo Joy , Liu Lu , Zhang Shuwen , Lu Jing , Zhang Cai , Pang Xiaoyang , Lv Jiaping
Published: March 2019

Thein vitroinhibitory effect of sprouted quinoa yoghurt beverages (QYB) fermented with anti-diabetic lactic acid bacteria on α-amylase was investigated.
Image-based analysis of uniaxial ring test for mechanical characterization of soft materials and biological tissues
Authors: van Haaften Eline E. , van Turnhout Mark C. , Kurniawan Nicholas A.
Published: March 2019

We propose a simple image-based analysis approach to accurately estimate the mechanical properties of ring-shaped materials.
Narrow optical gap ferroelectric Bi2ZnTiO6 thin films deposited by RF sputtering
Authors: Figueiras Fábio G. , Fernandes J. Ramiro A. , Silva J. P. B. , Alikin Denis O. , Queirós Eugénia C. , Bernardo César R. , Barcelay Y. R. , Wrzesińska Angelika , Belsley M. S. , Almeida Bernardo , Tavares Pedro B. , Kholkin Andrei L. , Moreira J. Agostinho , Almeida Abílio
Published: March 2019

Thriving ferroelectric oxide Bi2ZnTiO6 thin films with a 1.48 eV optical gap.
A Li+conductive metal organic framework electrolyte boosts the high-temperature performance of dendrite-free lithium batteries
Authors: Chen Nan , Li Yuejiao , Dai Yujuan , Qu Wenjie , Xing Yi , Ye Yusheng , Wen Ziyue , Guo Cui , Wu Feng , Chen Renjie
Published: March 2019

Conventional electrolytes of Li metal batteries are highly flammable and volatile, which accelerates the consumption of lithium metal at high temperatures, resulting in catastrophic fires or explosions.
Disulfide crosslinking and helical coiling of peptide micelles facilitate the formation of a printable hydrogel
Authors: Yang Xin , Wang Yuefei , Qi Wei , Xing Ruizhe , Yang Xuejiao , Xing Qiguo , Su Rongxin , He Zhimin
Published: March 2019

Tripeptides self-assembled into aligned micelles which transformed into nanohelices via covalent and noncovalent interactions to give a printable hydrogel.
Remarkably enhanced ferromagnetism in a super-exchange governed Cr2Ge2Te6 monolayer via molecular adsorption
Authors: He Junjie , Ding Guangqian , Zhong Chengyong , Li Shuo , Li Dengfeng , Zhang Gang
Published: March 2019

We present that gas molecule adsorption can effectively enhance the ferromagnetism of a 2D magnetic Cr2Ge2Te6 monolayer.
Recent progress in quantum dot sensitized solar cells: an inclusive review of photoanode, sensitizer, electrolyte, and the counter electrode
Authors: Chebrolu Venkata Thulasivarma , Kim Hee-Je
Published: March 2019

We present a comprehensive overview of the development of quantum dot-sensitized solar cells (QDSCs), including photoanodes, sensitizers, electrolytes, and counter electrodes, and discuss future prospects for the development of highly efficient and stable QDSCs.
Nonlinear microscopy of common histological stains reveals third harmonic generation harmonophores
Authors: Kazarine Alexei , Gopal Angelica A. , Wiseman Paul W.
Published: March 2019

Common histological stains provide excellent contrast as THG harmonophores, enabling high resolution imaging of histological samples.
Development of a biomimetic enzyme-linked immunosorbent assay based on a molecularly imprinted polymer for the detection of cortisol in human saliva
Authors: Spano Giulia , Cavalera Simone , Di Nardo Fabio , Giovannoli Cristina , Anfossi Laura , Baggiani Claudio
Published: March 2019

A molecularly imprinted sorbent assays for cortisol was optimized for direct determination in human saliva.
Thiolated γ-polyglutamic acid as a bioadhesive hydrogel-forming material: evaluation of gelation, bioadhesive properties and sustained release of KGF in the repair of injured corneas
Authors: Xu He-Lin , Tong Meng-Qi , Wang Li-Fen , Chen Rui , Li Xin-Ze , Sohawon Yasin , Yao Qing , Xiao Jian , Zhao Ying-Zheng
Published: March 2019

Keratinocyte growth factor (KGF) has a good therapeutic effect on injured corneas.
Y8O(OH)15(CO3)3Cl: an excellent short-wave UV nonlinear optical material exhibiting an infrequent three-dimensional inorganic cationic framework
Authors: Zhang Yiting , Long Ying , Dong Xuehua , Wang Lei , Huang Ling , Zeng Hongmei , Lin Zhien , Wang Xin , Zou Guohong
Published: March 2019

An excellent short-wave UV nonlinear optical material, Y8O(OH)15(CO3)3Cl, featured an infrequent three-dimensional inorganic cationic framework.
BiCl3-Mediated direct functionalization of unsaturated C–C bonds with an electrophilic SCF2PO(OEt)2 reagent
Authors: Wang Jianjun , Xiong Heng-Ying , Petit Emilie , Bailly Laëtitia , Pannecoucke Xavier , Poisson Thomas , Besset Tatiana
Published: March 2019

A general access to challenging and unprecedented C(sp)–, C(sp2)– and C(sp3)–SCF2PO(OEt)2 bonds via a BiCl3 mediated transformation.
An unexpected multi-component one-pot cascade reaction to access furanobenzodihydropyran-fused polycyclic heterocycles
Authors: Guo Jiaomei , Miao Hongjie , Zhao Yang , Bai Xuguan , Zhu Yanshuo , Wang Qilin , Bu Zhanwei
Published: March 2019

An unexpected multi-component one-pot cascade reaction of hydroxyketones with ortho-hydroxychalcones has been developed to afford an array of new furanobenzopyran-fused polycyclic compounds with complex molecular architectures.
Effective electron–hole separation over a controllably constructed WP/UiO-66/CdS heterojunction to achieve efficiently improved visible-light-driven photocatalytic hydrogen evolution
Authors: Zhang Yongke , Jin Zhiliang
Published: March 2019

The photocatalytic decomposition of water to produce hydrogen is an important strategy to effectively utilize solar energy and solve the energy crisis.
Synthesis and reactivity at the Ir-MeTpm platform: from κ1-Ncoordination to κ3-N-based organometallic chemistry
Authors: Fernández-Alvarez Francisco J. , Polo Víctor , García-Orduña Pilar , Lahoz Fernando J. , Pérez-Torrente Jesús J. , Oro Luis A. , Lalrempuia Ralte
Published: March 2019

Preparation of iridium complexes with the tris(3,5-dimethylpyrazol-1-yl)methane (MeTpm) ligand in κ1-N, κ2-Nand κ3-Ncoordination modes.
Coordination self-assembly through weak interactions in meso-dialkoxyphosphoryl-substituted zinc porphyrinates
Authors: Nefedov Sergey E. , Birin Kirill P. , Bessmertnykh-Lemeune Alla , Enakieva Yulia Y. , Sinelshchikova Anna A. , Gorbunova Yulia G. , Tsivadze Aslan Y. , Stern Christine , Fang Yuanyuan , Kadish Karl M.
Published: March 2019

Non-coordinating aryl substituents determine the organization of zinc meso-(diethoxyphosphoryl)diarylporphyrins in crystals and in solution.
Luminescent properties of a 3,5-diphenylpyrazole bridged Pt(ii) dimer
Authors: Cinninger Leander M. , Bastatas Lyndon D. , Shen Yulong , Holliday Bradley J. , Slinker Jason D.
Published: March 2019

We report the synthesis, electrochemistry, photophysics and electroluminescence of a highly luminescent pyrazolate-bridged platinum(ii) complex. Light-emitting electrochemical cells (LEECs) of this dimer complex were among the brightest and most efficient LEECs from dinuclear compounds to date.
A general route via formamide condensation to prepare atomically dispersed metal–nitrogen–carbon electrocatalysts for energy technologies
Authors: Zhang Guoxin , Jia Yin , Zhang Cong , Xiong Xuya , Sun Kai , Chen Ruida , Chen Wenxing , Kuang Yun , Zheng Lirong , Tang Haolin , Liu Wen , Liu Junfeng , Sun Xiaoming , Lin Wen-Feng , Dai Hongjie
Published: March 2019

We developed a novel methodology for the general synthesis of non-precious transition metal–nitrogen–carbon electrocatalysts based on formamide condensation.
Dietary l-tryptophan alleviated LPS-induced intestinal barrier injury by regulating tight junctions in a Caco-2 cell monolayer model
Authors: Chen Mengdie , Liu Yuyu , Xiong Shanbai , Wu Moucheng , Li Bin , Ruan Zheng , Hu Xiaobo
Published: March 2019

The intestinal epithelial layer forms a barrier through cell–cell tight junctions and breaking or even slightly disrupting this barrier can lead to serious pathological consequences, including infection and inflammation.
One-pot chemocatalytic transformation of cellulose to ethanol over Ru-WOx/HZSM-5
Authors: Li Chuang , Xu Guangyue , Wang Chenguang , Ma Longlong , Qiao Yan , Zhang Ying , Fu Yao
Published: March 2019

One-pot chemocatalytic transformation of cellulose to ethanol over Ru-WOx/HZSM-5 with carbon yield as high as 87.5%.
High-throughput acoustofluidic fabrication of tumor spheroids
Authors: Chen Bin , Wu Yue , Ao Zheng , Cai Hongwei , Nunez Asael , Liu Yunhua , Foley John , Nephew Kenneth , Lu Xiongbin , Guo Feng
Published: March 2019

Three-dimensional (3D) culture of multicellular spheroids, offering a desirable biomimetic microenvironment, is appropriate for recapitulating tissue cellular adhesive complexity and revealing a more realistic drug response.
Nanoscale antiadhesion properties of sophorolipid-coated surfaces against pathogenic bacteria
Authors: Valotteau Claire , Baccile Niki , Humblot Vincent , Roelants Sophie , Soetaert Wim , Stevens Christian V. , Dufrêne Yves F.
Published: March 2019

By means of single-cell force nanoscopy we show that sophorolipid biosurfactants feature unusually strong antiadhesion properties against nosocomial pathogens involved in catheter-related infections.
A simply designed galvanic device with an electrocatalytic reaction
Authors: Yin Shuang , Liu Wenlu , Yao Shupu , Du Xinpei , Song Peng , Wang Zhan
Published: March 2019

A galvanic device demonstrates the improvement of both the voltage efficiency and energy storage abilityviaan electrochemical homogeneous catalytic reaction.
Ostwald ripening of confined nanoparticles: chemomechanical coupling in nanopores
Authors: Gommes Cedric J.
Published: March 2019

Ostwald ripening of confined particles entails their mechanical interaction with the porous support, and occasionally its breaking.
Modified graphene/polyimide composite films with strongly enhanced thermal conductivity
Authors: Wu Xian , Li Haoliang , Cheng Kui , Qiu Hanxun , Yang Junhe
Published: March 2019

An effective “modified-welding” approach to prepare graphene films with excellent thermal conductivity and flexibility for highly efficient thermal management.
Doxorubicin-reinforced supramolecular hydrogels of RGD-derived peptide conjugates for pH-responsive drug delivery
Authors: Mei Leixia , Xu Keming , Zhai Ziran , He Suyun , Zhu Tingting , Zhong Wenying
Published: March 2019

Doxorubicin reinforced the self-assembly of RGD-derived peptide conjugates responsive to mild acidity.
Solid phase syntheses of peptoid like arylureido compounds and sequencing of isobars without molecular encoding
Authors: Asif Kanwal , O'Brien Gregory L. , Goodman Scott M. , Suwal Sujit
Published: March 2019

Isobaric arylureido peptoids undergo SS1 and SS2 fragmentations in MALDI-TOF MS/MS, thus offering a sequencing mechanism for arylureides without molecular encoding.
BINOL-derived bifunctional sulfide catalysts for asymmetric synthesis of 3,3-disubstituted phthalides via bromolactonization
Authors: Okada Megumi , Kaneko Kazuma , Yamanaka Masahiro , Shirakawa Seiji
Published: March 2019

An efficient enantioselective synthesis of 3,3-disubstituted phthalides possessing a chiral quaternary carbon center was achieved via catalytic asymmetric bromolactonization using BINOL-derived bifunctional sulfide catalysts.
Radical fluoroalkylation reactions of (hetero)arenes and sulfides under red light photocatalysis
Authors: Yerien Damian E. , Cooke M. Victoria , García Vior M. Cecilia , Barata-Vallejo Sebastián , Postigo Al
Published: March 2019

The use of Zn-phthalocyanine in a red-light-driven process for the perfluoroalkylation reactions of (hetero)arenes and sufides represents a friendlier environmental alternative.
Facile access to 1,3-diketones by gold(i)-catalyzed regioselective hydration of ynones
Authors: Kuang Jinqiang , Zhou Tao , You Tingjie , Chen Jianhui , Su Chenliang , Xia Yuanzhi
Published: March 2019

A regioselective hydration of ynones was developed via gold catalysis, providing a simple, mild, and efficient method for the synthesis of a variety of 1,3-diketone derivatives.
Synthesis and antiproliferative evaluation of new zampanolide mimics
Authors: Chen Guanglin , Patanapongpibul Manee , Jiang Ziran , Zhang Qiang , Zheng Shilong , Wang Guangdi , White James D. , Chen Qiao-Hong
Published: March 2019

A suitably designed side chain can serve as a bioisostere for the N-acyl heminal side chain of zampanolide.
Tin nanoparticles embedded in an N-doped microporous carbon matrix derived from ZIF-8 as an anode for ultralong-life and ultrahigh-rate lithium-ion batteries
Authors: Han Qingqing , Jin Ting , Li Yang , Si Yuchang , Li Haixia , Wang Yijing , Jiao Lifang
Published: March 2019

A carbon matrix with abundant micropores derived from ZIF-8 can confine Sn particles in an ultrasmall nanosize, contributing to the buffering of the huge volume changes.
Study of through-space substituent–π interactions using N-phenylimide molecular balances
Authors: Hwang Jungwun , Li Ping , Vik Erik C. , Karki Ishwor , Shimizu Ken D.
Published: March 2019

Substituent–π interactions associated with aromatic stacking interactions were experimentally measured using a small N-phenylimide molecular balance model system.
Fabrication of gradient vapor grown carbon fiber based polyurethane foam for shape memory driven microwave shielding
Authors: Yan Yongjie , Xia Hong , Qiu Yiping , Xu Zhenzhen , Ni Qing-Qing
Published: March 2019

Gradient vapor grown carbon fiber (VGCF) based shape memory polyurethane foam (VGCF@SMPUF) was fabricated by alternate dipping in a gradually diluted VGCF@SMPU/DMF solution and distilled water for shape memory driven microwave shielding.
Biotransformation of 4-methylcoumarins by cambial meristematic cells of Camptotheca acuminata
Authors: Zhang Yuhua , Jiang Jiayi , Qin Ningbo , Zhang Qian , Yan Chunyan
Published: March 2019

Cambial meristematic cell (CMC) suspension cultures were investigated as a new biotransformation system for the first time.
Amino-polystyrene supported hexaethylene glycol-bridged ionic liquid as an efficient heterogeneous catalyst for water-mediated nucleophilic hydroxylation
Authors: Reddy Mudumala Veeranarayana , Kang Seok Min , Yoo Suah , Woo Sang Sik , Kim Dong Wook
Published: March 2019

An amino-polystyrene supported hexaethylene glycol-bridged ionic liquid (APS-HEGBIL) was remarkably efficient at catalyzing the selective nucleophilic hydroxylation of alkyl halides to produce the corresponding alcohols in water.
Controlled inter-state switching between quantized conductance states in resistive devices for multilevel memory
Authors: Deswal Sweety , Malode Rupali R. , Kumar Ashok , Kumar Ajeet
Published: March 2019

Stable quantized conductance states were achieved and controllably switched to higher or to lower conductance states for multilevel memory.
Formation of disk-like micelles of triblock copolymers in frustrating solvents
Authors: Zhu Hongyan , Cui Yan , Wang Jie , Qiu Huibin
Published: March 2019

Self-assembly of amphiphilic triblock copolymers in a frustrating solvent system leads to the formation of various low-curvature micellar structures.
Strong interface scattering induced low thermal conductivity in Bi-based GeTe/Bi2Te3 superlattice-like materials
Authors: Zhou Yang , Huang Kaijin , Zhou Lingjun , Cheng Xiaomin , Xu Ming , Tong Hao , Miao Xiangshui
Published: March 2019

Strong interface scattering caused by Bi atoms in Bi-based GeTe/Bi2Te3 superlattice-like materials leads to the decrease of thermal conductivity.
Evaluation of the effects of cross-linking and swelling on the mechanical behaviors of hydrogels using the digital image correlation method
Authors: Uchida Makoto , Sengoku Tatsuya , Kaneko Yoshihisa , Okumura Dai , Tanaka Hiro , Ida Shohei
Published: March 2019

The effects of cross-linking and swelling on the true stress–strain response of hydrogel were evaluated using DIC, and the mechanical response was fitted based on a non-Gaussian statistical model.
Robust and anti-fatigue hydrophobic association hydrogels assisted by titanium dioxide for photocatalytic activity
Authors: Gao Yang , Gu Song , Duan Lijie , Wang Yuanrui , Gao Guanghui
Published: March 2019

Hydrophobic association hydrogels assisted by TiO2 exhibited excellent mechanical strength, fatigue resistance and desirable photocatalytic capacity for various dyes.
Highly efficient phenothiazine 5,5-dioxide-based hole transport materials for planar perovskite solar cells with a PCE exceeding 20%
Authors: Ding Xingdong , Chen Cheng , Sun Linghao , Li Hongping , Chen Hong , Su Jie , Li Huaming , Li Henan , Xu Li , Cheng Ming
Published: March 2019

Two novel highly efficient and low-cost phenothiazine 5,5-dioxide core building block based hole transport materials are reported, achieving a power conversion efficiency as high as 20.2%.
Identifying high-efficiency oxygen evolution electrocatalysts from Co–Ni–Cu based selenides through combinatorial electrodeposition
Authors: Cao Xi , Johnson Emily , Nath Manashi
Published: March 2019

(Co0.21Ni0.25Cu0.54)3Se2 has been identified as high-efficiency OER electrocatalyst with a low overpotential of 272 mV at 10 mA cm−2.
Importance of terminated groups in 9,9-bis(4-methoxyphenyl)-substituted fluorene-based hole transport materials for highly efficient organic–inorganic hybrid and all-inorganic perovskite solar cells
Authors: Zhang Dongyang , Wu‡ Tai , Xu Peng , Ou Yangmei , Sun Anxin , Ma Huili , Cui Bo , Sun Hanwen , Ding Liming , Hua Yong
Published: March 2019

Two fluorene-based HTMs have been synthesized for use in perovskite solar cells (PSCs). The (FAPbI3)0.85(MAPbBr3)0.15 and CsPbI2Br PSCs devices based on YT3 yield very impressive PCEs of 20.23% and 13.36%, respectively.
Diketopyrrolopyrrole-based conjugated materials for non-fullerene organic solar cells
Authors: Zhao Chaowei , Guo Yiting , Zhang Yuefeng , Yan Nanfu , You Shengyong , Li Weiwei
Published: March 2019

This review summarizes the recent progress of DPP-based conjugated materials, including small molecules and conjugated polymers, for application in non-fullerene organic solar cells.
Sonochemical functionalization of the low-dimensional surface oxide of Galinstan for heterostructured optoelectronic applications
Authors: Karbalaei Akbari Mohammad , Hai Zhenyin , Wei Zihan , Ramachandran Ranjith K. , Detavernier Christophe , Patel Malkeshkumar , Kim Joondong , Verpoort Francis , Lu Hongliang , Zhuiykov Serge
Published: March 2019

The functionalized low-dimensional surface oxides of liquid metal Galinstan were employed as the main component of heterostructured optoelectronic devices.
Molecular dynamics of C99-bound γ-secretase reveal two binding modes with distinct compactness, stability, and active-site retention: implications for Aβ production
Authors: Dehury Budheswar , Tang Ning , Kepp Kasper P.
Published: March 2019

The membrane protease γ-secretase cleaves the C99 fragment of the amyloid precursor protein, thus producing the Aβ peptides central to Alzheimer's disease. Cryo-electron microscopy has provided the topology but misses the membrane and loop parts that contribute to substrate binding. We report here an essentially complete atomic model of C99 within wild-type γ-secretase that respects all the experimental constraints and additionally describes loop, helix, and C99 substrate dynamics in a realistic all-atom membrane. Our model represents the matured auto-cleaved state required for catalysis. From two independent 500-ns molecular dynamic simulations, we identify two conformation states of C99 in equilibrium, a compact and a loose state. Our simulations provide a basis for C99 processing and Aβ formation and explain the production of longer and shorter Aβ, as the compact state retains C99 for longer and thus probably trims to shorter Aβ peptides. We expect pathogenic presenilin mutations to stabilize the loose over the compact state. The simulations detail the role of the Lys53–Lys54–Lys55 anchor for C99 binding, a loss of helicity of bound C99, and positioning of Thr48 and Leu49 leading to alternative trimming pathways on opposite sides of the C99 helix in three amino acid steps. The C99 binding topology resembles that of C83-bound γ-secretase without membrane but lacks a presenilin 1-C99 β-sheet, which could be induced by C83's stronger binding. The loose state should be selectively disfavored by γ-secretase modulators to increase C99 trimming and reduce the formation of longer Aβ, a strategy that is currently much explored but has lacked a structural basis.
FAM83D is associated with gender, AJCC stage, overall survival and disease-free survival in hepatocellular carcinoma
Authors: Liu Xuling , Gao Hong , Zhang Jie , Xue Dongying
Published: March 2019

Prognostic significance of family with sequence similarity 83, member D (FAM83D) in hepatocellular carcinoma (HCC) patients has not been well-investigated using Gene Expression Omnibus (GEO) series and TCGA database, we compared FAM83D expression levels between tumor and adjacent tissues, and correlated FAM83D in tumors with outcomes and clinico-pathological features in HCC patients. Validated in GSE33006, GSE45436, GSE84402 and TCGA, FAM83D was significantly overexpressed in tumor tissues than that in adjacent tissues (all P<0.01). FAM83D up-regulation was significantly associated with worse overall survival (OS) and disease-free survival (DFS) in HCC patients (Log rank P=0.00583 and P=4.178E-04, respectively). Cox analysis revealed that FAM83D high expression was significantly associated with OS in HCC patients [hazard ratio (HR) = 1.44, 95% confidence interval (CI) = 1.005–2.063, P=0.047]. Additionally, patients deceased or recurred/progressed had significantly higher FAM83D mRNA levels than those living or disease-free (P=0.0011 and P=0.0238, respectively). FAM83D high expression group had significantly more male patients and advanced American Joint Committee on Cancer (AJCC) stage cases (P=0.048 and P=0.047, respectively). FAM83D mRNA were significantly overexpressed in male (P=0.0193). Compared with patients with AJCC stage I, those with AJCC stage II and stage III–IV had significantly higher FAM83D mRNA levels (P = 0.0346 and P=0.0045, respectively). In conclusion, overexpressed in tumors, FAM83D is associated with gender, AJCC stage, tumor recurrence and survival in HCC.
Chromatin target of protein arginine methyltransferase regulates invasion, chemoresistance, and stemness in epithelial ovarian cancer
Authors: Feng Xiaojie , Li Lei , Wang Li , Luo Suxia , Bai Xupeng
Published: March 2019

Ovarian cancer is one of the most common gynecological cancers with a high mortality rate in females. Chromatin target of protein arginine methyltransferase (CHTOP) is an important intracellular protein that regulates the transcriptional activation of several oncogenic genes in glioblastomagenesis and controls mature mRNA export as a component of TRanscription-Export complex. However, the role of CHTOP in ovarian cancer is unclear. In the present study, we investigated the correlation between tumor-derived CHTOP expression and prognosis and explored its role in the malignant behaviors of epithelial ovarian cancer cells. We found that higher expression of CHTOP was associated with a lower disease-free survival (DFS) rate in ovarian cancer patients. Also, CHTOP was highly expressed in human ovarian cancer tissues compared with normal and adjacent tissues. Moreover, compared with IGROV-1 cell line, higher expression of CHTOP was also confirmed in the malignant ovarian cancer cell lines (OV-90 and SK-OV-3). Further results from wound-healing and Matrigel assay showed that CHTOP knockdown significantly reduced the migration and invasion ability of OV-90 and SK-OV-3 cells, while colony formation assay and apoptosis detection showed that CHTOP knockdown markedly sensitized OV-90 and SK-OV-3 cells to cisplatin treatment by inducing apoptosis. Additionally, CHTOP silence also remarkably weakened the stemness of OV-90 and SK-OV-3 through inhibiting the protein expressions of several transcriptional or surface markers of cancer stem cells. These findings first suggest that CHTOP, as a highly expressed protein in ovarian cancer, is closely associated with the malignant phenotypes of epithelial ovarian cancer cells, including metastasis, chemoresistance, and stemness, which highlights a promising role of CHTOP in ovarian cancer targeted therapy.