bluuebunny/crossref_metadata_2025 huggingface dataset:
Higher Levels of Low Molecular Weight Sulfur Compounds and Homocysteine Thiolactone in the Urine of Autistic Children
Authors: Gątarek Paulina , Rosiak Angelina , Borowczyk Kamila , Głowacki Rafał , Kałużna-Czaplińska Joanna
Published: February 2020

In this study, the levels of concentration of homocysteine thiolactone (HTL), cysteine (Cys), and cysteinylglycine (CysGly) in the urine of autistic and non-autistic children were investigated and compared. HTL has never been analyzed in autistic children. The levels of low molecular weight sulfur compounds in the urine of both groups were determined by validated methods based on high-performance liquid chromatography with spectrofluorometric and diode-array detectors. The statistical data show a significant difference between the examined groups. Children with autism were characterized by a significantly higher level of HTL (p = 5.86 × 10−8), Cys (p = 1.49 × 10−10) and CysGly (p = 1.06 × 10−8) in urine compared with the control group. A difference in the p-value of <0.05 is statistically significant. Higher levels of HTL, Cys, and CysGly in the urine of 41 children with autism, aged 3 to 17, were observed. The obtained results may indicate disturbances in the metabolism of methionine, Cys, and glutathione in some autistic patients. These preliminary results suggest that further research with more rigorous designs and a large number of subjects is needed.
PET Radiopharmaceuticals for Alzheimer’s Disease and Parkinson’s Disease Diagnosis, the Current and Future Landscape
Authors: Uzuegbunam Bright Chukwunwike , Librizzi Damiano , Hooshyar Yousefi Behrooz
Published: February 2020

Ironically, population aging which is considered a public health success has been accompanied by a myriad of new health challenges, which include neurodegenerative disorders (NDDs), the incidence of which increases proportionally to age. Among them, Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common, with the misfolding and the aggregation of proteins being common and causal in the pathogenesis of both diseases. AD is characterized by the presence of hyperphosphorylated τ protein (tau), which is the main component of neurofibrillary tangles (NFTs), and senile plaques the main component of which is β-amyloid peptide aggregates (Aβ). The neuropathological hallmark of PD is α-synuclein aggregates (α-syn), which are present as insoluble fibrils, the primary structural component of Lewy body (LB) and neurites (LN). An increasing number of non-invasive PET examinations have been used for AD, to monitor the pathological progress (hallmarks) of disease. Notwithstanding, still the need for the development of novel detection tools for other proteinopathies still remains. This review, although not exhaustively, looks at the timeline of the development of existing tracers used in the imaging of Aβ and important moments that led to the development of these tracers.
Encapsulation of β-Carotene by Emulsion Electrospraying Using Deep Eutectic Solvents
Authors: Basar Ahmet Ozan , Prieto Cristina , Durand Erwann , Villeneuve Pierre , Sasmazel Hilal Turkoglu , Lagaron Jose
Published: February 2020

The encapsulation β-carotene in whey protein concentrate (WPC) capsules through the emulsion electrospraying technique was studied, using deep eutectic solvents (DES) as solvents. These novel solvents are characterized by negligible volatility, a liquid state far below 0 °C, a broad range of polarity, high solubilization power strength for a wide range of compounds, especially poorly water-soluble compounds, high extraction ability, and high stabilization ability for some natural products. Four DES formulations were used, based on mixtures of choline chloride with water, propanediol, glucose, glycerol, or butanediol. β-Carotene was successfully encapsulated in a solubilized form within WPC capsules; as a DES formulation with choline chloride and butanediol, the formulation produced capsules with the highest carotenoid loading capacity. SEM micrographs demonstrated that round and smooth capsules with sizes around 2 µm were obtained. ATR-FTIR results showed the presence of DES in the WPC capsules, which indirectly anticipated the presence of β-carotene in the WPC capsules. Stability against photo-oxidation studies confirmed the expected presence of the bioactive and revealed that solubilized β-carotene loaded WPC capsules presented excellent photo-oxidation stability compared with free β-carotene. The capsules developed here clearly show the significant potential of the combination of DES and electrospraying for the encapsulation and stabilization of highly insoluble bioactive compounds.
Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer’s Disease
Authors: Varlow Cassis , Murrell Emily , Holland Jason P. , Kassenbrock Alina , Shannon Whitney , Liang Steven H. , Vasdev Neil , Stephenson Nickeisha A.
Published: February 2020

[18F]FPEB is a positron emission tomography (PET) radiopharmaceutical used for imaging the abundance and distribution of mGluR5 in the central nervous system (CNS). Efficient radiolabeling of the aromatic ring of [18F]FPEB has been an ongoing challenge. Herein, five metal-free precursors for the radiofluorination of [18F]FPEB were compared, namely, a chloro-, nitro-, sulfonium salt, and two spirocyclic iodonium ylide (SCIDY) precursors bearing a cyclopentyl (SPI5) and a new adamantyl (SPIAd) auxiliary. The chloro- and nitro-precursors resulted in a low radiochemical yield (<10% RCY), whereas both SCIDY precursors and the sulfonium salt precursor produced [18F]FPEB in the highest RCYs of 25% and 36%, respectively. Preliminary PET/CT imaging studies with [18F]FPEB were conducted in a transgenic model of Alzheimer’s Disease (AD) using B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J (APP/PS1) mice, and data were compared with age-matched wild-type (WT) B6C3F1/J control mice. In APP/PS1 mice, whole brain distribution at 5 min post-injection showed a slightly higher uptake (SUV = 4.8 ± 0.4) than in age-matched controls (SUV = 4.0 ± 0.2). Further studies to explore mGluR5 as an early biomarker for AD are underway.
Interplay between Polymorphism and Isostructurality in the 2-Fur- and 2-Thenaldehyde Semi- and Thiosemicarbazones
Authors: Swiatkowski Marcin , Trzesowska-Kruszynska Agata , Danielewicz Agnieszka , Sobczak Paulina , Kruszynski Rafal
Published: February 2020

The four compounds, namely: 5-nitro-2-furaldehyde thiosemicarbazone (1); 5-nitro-2-thiophene thiosemicarbazone (2); 5-nitro-2-furaldehyde semicarbazone (3); and 5-nitro-2-thiophene semicarbazone (4) were synthesized and crystallized. The three new crystal structures of 1, 2, and 4 were determined and compared to three already known crystal structures of 3. Additionally, two new polymorphic forms of 1 solvate were synthesized and studied. The influence of the exchange of 2-thiophene to 2-furaldehyde as well as thiosemicarbazone and semicarbazone on the self-assembly of supramolecular nets was elucidated and discussed in terms of the formed synthons and assemblies accompanied by Full Interaction Maps analysis. Changes in the strength of IR oscillators caused by the molecular and crystal packing effects are described and explained in terms of changes of electron density.
Inclusion of the Phytoalexin trans-Resveratrol in Native Cyclodextrins: A Thermal, Spectroscopic, and X-Ray Structural Study
Authors: Catenacci Laura , Sorrenti Milena , Bonferoni Maria Cristina , Hunt Lee , Caira Mino R.
Published: February 2020

The aim of the study was to determine the feasibility of complexation between the antioxidant trans-resveratrol (RSV) and underivatized cyclodextrins (CDs) using a variety of preparative methods, including physical mixing, kneading, microwave irradiation, co-evaporation, and co-precipitation techniques. Products were characterized using differential scanning calorimetry (DSC), simultaneous thermogravimetric/DSC analysis (TGA/DSC), Fourier transform infrared (FT-IR) spectroscopy, and powder X-ray diffraction (PXRD). With α-CD and RSV, sample amorphization was revealed by PXRD and FT-IR, but no definitive inclusion complexation was evident. Similar results were obtained in attempts to complex RSV with β-CD. However, complex formation between γ-CD and RSV was evident from observation of an endo-/exothermic effect appearing in the DSC trace of the product from kneading and was further corroborated by FT-IR and PXRD methods. The latter technique indicated complexation unequivocally as the diffraction peak profile for the product matched that for known isostructural γ-CD complexes. Single crystal X-ray analysis followed, confirming the predicted complex between γ-CD and RSV. A combination of 1H NMR and TGA data yielded the complex formula (γ-CD)3·(RSV)4·(H2O)62. However, severe disorder of the RSV molecules prevented their modeling. In contrast, our previous studies of the inclusion of RSV in methylated CDs yielded crystals with only minor guest disorder.
Chemical Standardization and Anti-Proliferative Activity of Ardisia elliptica Fruit against the HCT116 Human Colon Cancer Cell Line
Authors: Ondee Suchanuch , Sithisarn Pongtip , Mangmool Supachoke , Rojsanga Piyanuch
Published: February 2020

The present study is intended to carry out the chemical standardization and evaluation of the anti-proliferative activity of A. elliptica fruit extract. A. elliptica fruit powder was extracted with ethanol. The obtained extract was assessed for total phenolic content using the Folin–Ciocalteu method. Moreover, a simple, accurate, and precise reversed phase high-performance liquid chromatographic method was developed and validated to determine the embelin content of A. elliptica fruit extract. Then, the extract and embelin were investigated for their anti-proliferative effect against HCT-116 cells. Finally, the mechanisms of inhibition of the extract and embelin on the mRNA expression of pro-apoptotic genes Bad, Bax, and Caspase-8 and anti-apoptotic genes c-IAP1, Mcl-1, and XIAP were determined by real-time qRT-PCR. The phenolic content and embelin content of the extract were 5.20 ± 0.01 g of gallic acid equivalent per 100 g of dried fruit (g% GAE) and 5.57 ± 0.56 mg/g of extract, respectively. The extract and embelin showed strong anti-proliferative effects on HCT-116 cells with 50% inhibition concentration (IC50) values of 19.16 ± 1.09 µg/mL and 25.93 ± 1.75 µg/mL, respectively. The A. elliptica extract exhibited a significant increase in the mRNA level of Bad, Bax, and Caspase-8 and a significant decrease in c-IAP1, Mcl-1, and XIAP. Embelin showed a significant decrease in Mcl-1 and XIAP.
Complexes Between Adamantane Analogues B4X6 -X = {CH2, NH, O ; SiH2, PH, S} - and Dihydrogen, B4X6:nH2 (n = 1–4)
Authors: Oliva-Enrich Josep M. , Alkorta Ibon , Elguero José
Published: February 2020

In this work, we study the interactions between adamantane-like structures B4X6 with X = {CH2, NH, O ; SiH2, PH, S} and dihydrogen molecules above the Boron atom, with ab initio methods based on perturbation theory (MP2/aug-cc-pVDZ). Molecular electrostatic potentials (MESP) for optimized B4X6 systems, optimized geometries, and binding energies are reported for all B4X6:nH2 (n = 1–4) complexes. All B4X6:nH2 (n = 1–4) complexes show attractive patterns, with B4O6:nH2 systems showing remarkable behavior with larger binding energies and smaller B···H2 distances as compared to the other structures with different X.
Preparation of Electrospun Gelatin Mat with Incorporated Zinc Oxide/Graphene Oxide and Its Antibacterial Activity
Authors: Li Honghai , Chen Yu , Lu Weipeng , Xu Yisheng , Guo Yanchuan , Yang Geng
Published: February 2020

Current wound dressings have poor antimicrobial activities and are difficult to degrade. Therefore, biodegradable and antibacterial dressings are urgently needed. In this article, we used the hydrothermal method and side-by-side electrospinning technology to prepare a gelatin mat with incorporated zinc oxide/graphene oxide (ZnO/GO) nanocomposites. The resultant fibers were characterized by field emission environment scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffractometry (XRD) and Fourier transform infrared spectroscopy (FTIR). Results indicated that the gelatin fibers had good morphology, and ZnO/GO nanocomposites were uniformly dispersed on the fibers. The loss of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) viability were observed to more than 90% with the incorporation of ZnO/GO. The degradation process showed that the composite fibers completely degraded within 7 days and had good controllable degradation characteristics. This study demonstrated the potential applicability of ZnO/GO-gelatin mats with excellent antibacterial properties as wound dressing material.
Blood and Plasma Volumetric Absorptive Microsampling (VAMS) Coupled to LC-MS/MS for the Forensic Assessment of Cocaine Consumption
Authors: Mandrioli Roberto , Mercolini Laura , Protti Michele
Published: February 2020

Reliable, feasible analytical methods are needed for forensic and anti-doping testing of cocaine and its most important metabolites, benzoylecgonine, ecgonine methyl ester, and cocaethylene (the active metabolite formed in the presence of ethanol). An innovative workflow is presented here, using minute amounts of dried blood or plasma obtained by volumetric absorptive microsampling (VAMS), followed by miniaturized pretreatment by dispersive pipette extraction (DPX) and LC-MS/MS analysis. After sampling 20 µL of blood or plasma with a VAMS device, the sample was dried, extracted, and loaded onto a DPX tip. The DPX pretreatment lasted less than one minute and after elution with methanol the sample was directly injected into the LC-MS/MS system. The chromatographic analysis was carried out on a C8 column, using a mobile phase containing aqueous formic acid and acetonitrile. Good extraction yield (> 85%), precision (relative standard deviation, RSD < 6.0%) and matrix effect (< 12%) values were obtained. Analyte stability was outstanding (recovery > 85% after 2 months at room temperature). The method was successfully applied to real blood and plasma VAMS, with results in very good agreement with those of fluid samples. The method seems suitable for the monitoring of concomitant cocaine and ethanol use by means of plasma or blood VAMS testing.
Exergo-Economic Optimization of Organic Rankine Cycle for Saving of Thermal Energy in a Sample Power Plant by Using of Strength Pareto Evolutionary Algorithm II
Authors: Mehrdad Sina , Dadsetani Reza , Amiriyoon Alireza , Leon Arturo S. , Reza Safaei Mohammad , Goodarzi Marjan
Published: February 2020

Waste heat recovery plays an important role in energy source management. Organic Rankine Cycle (ORC) can be used to recover low-temperature waste heat. In the present work a sample power plant waste heat was used to operate an ORC. First, two pure working fluids were selected based on their merits. Four possible thermodynamic models were considered in the analysis. They were defined based on where the condenser and evaporator temperatures are located. Four main thermal parameters, evaporator temperature, condenser temperature, degree of superheat and pinch point temperature difference were taken as key parameters. Levelized energy cost values and exergy efficiency were calculated as the optimization criteria. To optimize exergy and economic aspects of the system, Strength Pareto evolutionary algorithm II (SPEA II) was implemented. The Pareto frontier solutions were ordered and chose by TOPSIS. Model 3 outperformed all other models. After evaluating exergy efficiency by mixture mass fraction, R245fa [0.6]/Pentane [0.4] selected as the most efficient working fluid. Finally, every component’s role in determining the levelized energy cost and the exergy efficiency and were discussed. The turbine, condenser and evaporator were found as the costliest components.
Y-Balance Test Performance Does Not Determine Non-Contact Lower Quadrant Injury in Collegiate American Football Players
Authors: Luedke Lace E. , Geisthardt Turner W. , Rauh Mitchell J.
Published: February 2020

Collegiate American football has a high rate of injury. The Lower Quarter Y-Balance Test (YBT-LQ), a dynamic assessment of lower extremity strength, mobility, and balance, has been purported to identify athletes at risk for injury in different sports including football. Previous studies examining the association between YBT-LQ and injury have reported varied findings; therefore, the purpose of this study was to assess if preseason YBT-LQ performance predicted whether football players would sustain a non-contact lower extremity or low back (lower quarter (LQ)) injury during the season. Fifty-nine male collegiate American football players (age 20.8 ± 1.3 y, height 1.8 ± 0.1 m, body mass 94.6 ± 14.2 kg) completed a survey of training and injury history and had their YBT-LQ performance assessed at the start of the season. Athletic training staff tracked the occurrence of non-contact LQ injuries during the season. There were no significant relationships found between preseason YBT-LQ values and incidence of non-contact LQ injury in this population of collegiate American football players. This study is consistent with recent reports that have not found a significant association between preseason YBT-LQ values and LQ injury. These results suggest that, in isolation, the YBT-LQ may have limited utility as a screening test for non-contact injury in collegiate football players.
Microplastics Exposure Causes Negligible Effects on the Oxidative Response Enzymes Glutathione Reductase and Peroxidase in the Oligochaete Tubifex tubifex
Authors: Scopetani Costanza , Esterhuizen Maranda , Cincinelli Alessandra , Pflugmacher Stephan
Published: February 2020

Microplastics (MPs) are emerging pollutants, which are considered ubiquitous in aquatic ecosystems. The effects of MPs on aquatic biota are still poorly understood, and consequently, there is a need to understand the impacts that MPs may pose to organisms. In the present study, Tubifex tubifex, a freshwater oligochaete commonly used as a bioindicator of the aquatic environment, was exposed to fluorescent polyethylene microspheres (up to 10 µm in size) to test whether the oxidative stress status was affected. The mortality rate of T. tubifex, as well as the activities of the oxidative stress status biomarker enzymes glutathione reductase and peroxidase, were assessed. In terms of oxidative stress, no significant differences between the exposure organisms and the corresponding controls were detected. Even though the data suggest that polyethylene MPs and the selected concentrations did not pose a critical risk to T. tubifex, the previously reported tolerance of T. tubifex to environmental pollution should be taken into account and thus MPs as aquatic pollutants could still represent a threat to more sensitive oligochetes.
The phenology of an urban street flora: a transect study
Authors: Preston Chris
Published: February 2020

Vascular plants in flower along a fixed 3.8 km route in eight streets in a primarily residential area of urban Cambridge, U.K., were recorded at monthly intervals between January 2016 and December 2019. There was a consistent annual pattern over the four years; the number of flowering species was greatest in June or July but there were still appreciable numbers of species flowering when totals were at their lowest in February or March. Five annuals (Capsella bursa-pastoris, Euphorbia peplus, Poa annua, Senecio vulgaris, Stellaria media) and one perennial (Parietaria judaica) were very frequent and flowered from January to December. Perennial species showed greater variation through the year than annual species. In most months the number of flowering British native species exceeded the combined number of archaeophytes and neophytes, but the native total peaked earlier in the summer and then declined more rapidly than that of the introductions. The transect method appeared to be effective in identifying the main annual phenological trends and also revealed the effects of extreme weather on the patterns in some seasons.
Cotula alpina (Asteraceae) naturalised in the British Isles
Authors: Walker Kevin J. , Robinson Linda , Donald Duncan
Published: February 2020

Cotula alpina (Hook f.) Hook f. is an Australian herb that has been naturalised in Britain since the 1970s and is now locally abundant in parts of northern England and northwest Scotland. Its method of arrival is unknown but it is likely to have originated from gardens and perhaps also from wool shoddy. It appears to be spreading rapidly due to high seed production and effective dispersal by sheep, humans and vehicles and is now locally abundant on moorland tracks and in adjacent acid grassland and heather moorland managed for grouse. Due to its evergreen and mat-forming habit it can outcompete community dominants such as Agrostis capillaris and Festuca ovina in areas where levels of grazing are high. It appears to be well suited to the British climate and is therefore likely to spread into similar habitats in other regions where it could pose a threat to localized species associated with short grassland on acidic soils. Its overall abundance and ability to regenerate rapidly from seed means it is unlikely to be easily controlled or eradicated, although exclusion of grazing may help to reduce its abundance in some areas.
Determination of mineral concentrations in stem and seed of Juncus acutus
Authors: ERDEM Funda , ÇETİNKAYA Nurcan
Published: February 2020

The objective of this study was to determine micro and macro mineral concentrations in stem and seed of Juncus acutus for ruminant nutrition. The samples of Juncus acutus stem and seed were randomly collected from Kizilirmak Delta, Samsun, Turkey. Micro and macro mineral concentrations of samples were analyzed by using an inductively coupled plasma mass spectrophotometer (ICP-MS) and ion chromatography (IC) methods, respectively. Differences between mean concentrations of B, Al, Cr, Mn, Fe, Co, Ni, Cu, Zn and Se in stem and seed of Juncus acutus samples were significant (P<0.05). The mean values of Al, Cr, Fe, Co, Ni and Se for stem of Juncus acutus were higher than values for seed of Juncus acutus but, the mean values of Mn, Cu and Zn for seed of Juncus acutus were higher than stem of Juncus acutus (P<0.05). The concentrations of Na, K and Ca in stem were higher than seed of Juncus acutus. On the other hand, the concentration of Mg for seed of Juncus acutus were higher than stem of Juncus acutus (P<0.05). In conclusion, the obtained results show that stem and seed of Juncus acutus may be a good source to meet the micro and macro mineral requirements of ruminant animals. Besides, the seeds of Juncus acutus may also provide micro and macro minerals to birds in wetlands.
Transdisciplinaridade e Universidade
Authors: Paul Patrick
Published: February 2020

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Animação educativa para Transtornos do Ritmo Circadiano por mudanças de fuso horário
Authors: Barros Marcos Paes de , Pereira Eleida de Camargo , Carvalho Luciane Bizari Coin de , Ferreira Vanessa Ruotolo , Prado Lucila Bizari Fernandes do , Prado Gilmar Fernandes do
Published: February 2020

Introdução. O transtorno do ritmo circadiano por mudança de fuso horário (jet lag) é causado por um dessincronismo entre o relógio bio­lógico e os indicadores de tempo externo. Ocorre quando uma pessoa viaja em aeronaves, através de vários fusos horários, em um curto espa­ço de tempo causando distúrbios do sono, distúrbios gastrointestinais, diminuição nos níveis de alerta e prejuízos nas funções diárias. O ob­jetivo do estudo foi criar uma animação para auxiliar a compreensão e conscientização sobre este distúrbio, destinando-se as pessoas que via­jam de avião em longas distâncias. Método. Levantamentos bibliográ­fico e mercadológico e processo de criação, subdivididos em três fases distintas: definição do público e estratégia comunicacional, criação e produção da animação desenvolvida. Resultados. A animação foi feita no formato de mídia (AVI), sendo desenvolvida uma história com ro­teiro, personagens e cenários que aproximam a animação do viajante, facilitando o processo de entendimento. Conclusão. A veiculação da animação para conscientização e informação sobre o transtorno do ritmo circadiano por mudança de fuso horário (jet lag) desenvolvida neste estudo pode ter um impacto positivo na saúde minimizando os sintomas e melhorando a qualidade de vida de quem realiza viagens internacionais.

Vídeo Programa do Dr. Hans
ТИПОЛОГІЯ АКАДЕМІЧНИХ ЗДІБНОСТЕЙ УЧНІВ ОСНОВНОЇ ШКОЛИ З РІЗНОЮ УСПІШНІСТЮ У НАВЧАННІ
Authors: Щербакова О.
Published: February 2020

Aim of the study to determine the typology of academic ability of the middle school students.

Methodology. The study used the Amthauer test to evaluate verbal, non-verbal (spatial) and mathematical intelligence for students in grades 7-9, a non-verbal subtest of the E. Torrens method, an adapted method for the psychodiagnostics of E. Deci and R. Ryan's academic self-regulation for students. In total, 331 pupils of 7-9 grades participated in the study (204 pupils study under the Intelligence of Ukraine project, 127 pupils of gymnasiums), including 189 academically successful pupils and 142 academically unsuccessful pupils aged 11-15.

Results. Using cluster analysis, five profiles of academic abilities of successful pupils and three profiles of academically unsuccessful pupils were obtained.

Conclusions. According to the results of a cluster analysis of academic abilities of successful and unsuccessful students of the middle school, a typology of academic abilities was obtained. Academically successful pupils are presented with five types of academic ability, characterized by different ratios of high levels of verbal, mathematical, and spatial intelligence, high or moderate levels of creativity, different levels of internal and external motivation, and high or moderately high overall and partial success. High academic performance is ensured by high intelligence in different ratios of creativity, motivation, partial and overall success. Academically unsuccessful pupils within the three typological profiles differ in the level of intelligence, motivation and partial success. Against the background of a sufficiently high level of intelligence with low motivation, or with insufficient intellectual talent against a background of high intrinsic motivation, or with a decrease in all parameters of academic ability, students have a decline in academic performance.
Field research and methodologies for textile industry innovation in thecontext of European economy
Authors: AILENI RALUCA MARIA , CHIRIAC LAURA , SURDU LILIOARA , RADULESCU RAZVAN ION
Published: February 2020

This paper presents several aspects concerning the field and desk research based on the methodologies in the contextof the European economy. Also, this work presents brief aspects about innovation, fundamental, applied research andneeds of training in the textile sector for managers, students, assistant managers and experts from Romania. Asurvey-based on questionnaires and statistical analysis was performed, in order to achieve the landscape of trainingneeds in the area of the Bucharest region.
МЕСТНЫЕ ТЕХНИЧЕСКИЕ УСЛОВИЯ РАЗМЕЩЕНИЯ И КРЕПЛЕНИЯ В УНИВЕРСАЛЬНЫХ ЖЕЛЕЗНОДОРОЖНЫХ ПОЛУВАГОНАХ КОММУНАЛЬНЫХ ОТХОДОВ В ПАКЕТИРОВАННОМ ВИДЕ
Authors: Акулов А.М. , Akulov A.M.
Published: February 2020

Рассматриваются Местные технические условия (МТУ) № 1808.07 для размещения и крепления коммунальных отходов несортированных и сортированных в пакетированном виде для перевозок в железнодорожных полувагонах. Дается анализ расчету допускаемых продольных и поперечных значений смещения общего центра тяжести груза в вагоне.
ЭКОНОМИЧЕСКАЯ ЭФФЕКТИВНОСТЬ ВНЕДРЕНИЯ ЦИФРОВОЙ ЛОГИСТИКИ И ЦИФРОВЫХ БЕРЕЖЛИВЫХ ТЕХНОЛОГИЙ В ОАО «РЖД»
Authors: Ефимова О.В. , Efimova O.V. , Орлова Е.Н. , Orlova E.N.
Published: February 2020

Рассматривается оценка эффективности цифровых трансформаций транспортных систем и применение цифровых бережливых технологий. Они обеспечат получение синергетического эффекта от взаимодействия всех участников транспортно-логистического рынка за счет устранения потерь на всех этапах жизненного цикла создания умных производственных систем на транспорте в формате индустрии.
НЕКОТОРЫЕ АСПЕКТЫ ПРОФИЛАКТИКИ КОНФЛИКТНОГО ПОВЕДЕНИЯ В ЭКИПАЖЕ ВОЗДУШНОГО СУДНА
Authors: Ариничева О.В. , Arinicheva O.V. , Малишевский А.В. , Malishevsky A.V.
Published: February 2020

Статья продолжает цикл исследований по выявлению предикторов, обусловливающих соответствующий стиль поведения личности в конфликтной ситуации. Приводятся результаты эксперимента, где в качестве личностной особенности, определяющей предпочитаемый стиль поведения в конфликте, рассматривались характеристики информационного метаболизма человека. Рассчитаны корреляции между выраженностью того или иного стиля поведения в конфликте и возможностью проявления отдельных психологических установок и функций, а также составляющими соционической модели человека. Полученные результаты сравниваются с аналогичными исследованиями, опубликованными в литературных источниках.
СОВЕРШЕНСТВОВАНИЕ ТЕХНОЛОГИИ ОБСЛУЖИВАНИЯ ПОТРЕБИТЕЛЕЙ ЭНЕРГОРЕСУРСОВ С ИСПОЛЬЗОВАНИЕМ ИНФОРМАЦИОННЫХ СИСТЕМ
Authors: Сирина Н.Ф. , Sirina N.F. , Зубков В.В. , Zubkov V.V.
Published: February 2020

Рассматривается организация транспортного процесса потребителей и поставщиков энергоресурсов. Делается вывод о необходимости совершенствования производственного процесса и транспортного обслуживания в железнодорожном местном сообщении в сегменте грузовых перевозок. Предложен информационный ресурс в виде системы управления «Контроль завоза, наличия и остатков угля на складах жилищнокоммунального хозяйства». При создании системы использовались методы адаптивного управления и принципы модульного структурирования.
EFFECTIVENESS OF ‘ON THE JOB TRAINING METHOD - PRESENTATION SKILLS IN WORKSHOP’ FOR COMPETITIVE PERFORMANCE
Authors: Gangadhar C. , Megharaj Dr. B. R.
Published: February 2020

The aim of training and orientation is to make the employees understand what to do and how to do. Orientation provides the employee with the information on company rules which are to be needed to get emotionally attached with the work place. It aims at making them to feel at home, introduces the work behaviour expected, helps to understand the organization as a whole and to socialize with the organizations culture, people etc. The insurance sector plays a very crucial role in the economy of any country – it increases avenues for savings of individuals, protects the future of individuals and spreads risks of institutions by forming a large pool of fund. The sector also contributes significantly to the capital markets and assists in large capital infrastructure developments of our country through their funds. Review of related literature in the area of life insurance services, products, private life insurance companies, awareness about insurance policies, perception of the policy holders, buying behaviour of the policy holders and policy holder satisfaction had been made by the researcher to establish validity of the research on Training Methods like On the job training, Off the job training and combination training in insurance industry. The present research is descriptive and conclusive, involving illustration and explanation descriptively followed by conclusions based on findings. It encompasses “Training Methods for Competitive Performance” (A study with reference to SBI Life, Andhra Pradesh). Primary data gathered by questionnaires form the empirical base which undergoes Statistical processing leading to findings. Findings are then transformed into suggestions and conclusions with inputs from the researcher’s academic experience.

KEY WORDS: Insurance, Training, perception, On the job training, Competitive Performance
Hermeneutika Manhaj Tafsir Fazlur Rahman
Authors: Abu Yazid Adnan Quthny
Published: February 2020

As a method of Tafsir - in the context of classical science -, hermeneutics is used to solve, interpret and interpret the meanings contained in scriptures, jurisprudence, ancient documents and texts. Hermeneutics as a theory of interpretation will surely give birth to hetereutic products as operational-applications tafsirnya. Fazlur Rahman is one of contemporary Muslim thinkers using the hermeneutic approach in nash interpretation. He grew up in a strong family environment in holding religious teachings by adopting a system of schools against Imam Hanafi (Sunni) as a figure of mujtahid madhhab ulama with traditional-conventional Islamic thinking and developing his scholarship to Western world which influenced many modern-contemporary thinking patterns. Rahman's education with traditional and contemporary background is apparent in his ijtihad results by carrying on the Qur'an, systematic-interpretation and logical-synthesis approaches. Rahman's traditional-liberal form of thought can be understood from his superior theory of double movement theory which was launched in 1982 AD with his basic ideas and ideas about the fundamental differences between the legal aspects of the Qur'an and the ideal aspects of the moral al -Qur'an. The integration of an education system of the traditional system in the state of origin (Pakistan) with the modern system of philosophy while continuing its studies in the West (France) made Rahman consistent with the position of al-Qur'an and sunna as the source of the first and main Islamic teachings as a means to uncover the meaning of the text and messages of both mashdar al-hukm. Fazlur Rahman classified as a unique and prominent thinker of his time is very interesting to be studied. He grew up in Pakistan and expanded his science to France and then to Chicago Canada who was later invited by his local government to return to help in Pakistan. But his struggle in his birthplace did not last long which made Rahman have to move back to Chicago, Canada. It seems like this hijrah experience as a reference to make it easier to remind us of the popular hermeneutic theory which is also pacing or reciprocity between inductive and deductive ie double movement theory around text, context and contextualization

Keywords: method , Tafsir and hermeneutics
Baitul Mal pada Masa Rasulullah Saw dan Khulafaur Al-Rashidin
Authors: Moh. Ahyar Maarif
Published: February 2020

Pembahasan utama pada makalah ini adalah keberadaan Baitul Mal sebagai pelopor utama dalam bidang keuangan yang sesuai dengan shariat Islam. Baitul Mal tidak hanya sebagai lembaga yang mengatur pemasukan uang negara, namun juga memiliki tugas yang begitu penting dalam pendistribusian uang hasil negara yang tersimpan di Baitul Mal, agar harta-harta tersebut dapat diterima oleh orang-orang yang berhak menerimanya. Dengan makalah ini, penulis menjelaskan secara singkat mengenai sumber pendapatan dan manajemen Baitul Mal yang dimulai sejak zaman Rasulullah SAW hingga pada masa pemerintahan Khulafau al-Rashidin. Keberadaan Baitul Mal ini bertujuan untuk mencapai salah satu tujuan dari negara, untuk menegakkan sistem kenegaraan yang berkenaan dengan pelaksanaan kewajiban muslim, seperti salat, zakat dan sebagainya.

Kata Kunci: Baitul Mal, Khulafau al-Rashidin, tujuan pendirian
Pandangan Hukum Islam tentang Denda Akibat Pembatalan Pinangan (Khitbah) oleh Pihak Perempuan
Authors: Fathullah
Published: February 2020

Khitbah or application or proposal is a preliminary or pre-marriage period between a man and a woman, as a first step before the two carry out the marriage contract, so that each knows the candidate. The sermon itself must still be answered “yes” or “no”. If it has been answered “yes”, then be the woman as “makhtubah” or the woman who is officially applied. In connection with this engagement in society there is a habit at the time of its implementation, the prospective bridegroom gives a gift such as jewelry, money, food and produce as a sign that someone really intends to continue the marriage stage. the consequences of giving the prize are different from giving in the form of dowry Giving a grant that is not halal withdraws the grant, if he gives a grant voluntarily (charity), not for compensation. While the grantor who still has the right to withdraw the grant, if the grant is given in return for something that will be received, but he does not get it.

Keyword: Islamic Law, Khitbah, Islamic Law
Sukuk (Obligasi Syariah) dalam Perspektif Keuangan Islam
Authors: Maula Nasrifah
Published: February 2020

Islam strongly encourages investment so that possessions can be productive and bring benefits in the future, of course, using a good and right way, which is in accordance with Islamic sharia, like mutual respect and does not harm others. The type of investment can be varied, we can invest through the capital market, one of which is sukuk. Sukuk are securities that are proof of ownership (claim) on assets, whether in the form of tangible, intangible or project contracts from certain activities that require the issuer to pay revenue-sharing to the Sukuk holders and pay back the Sukuk in maturity date. The principle in Sukuk transactions is in the form of emphasis on fair agreements, recommendations for profit sharing systems. In Sukuk transaction, a number of certain assets are needed which to used as the basis for conducting transactions using a contract based on sharia principles. The types of Sukuk in terms of Sukuk Ijarah, Sukuk Mudharabah, Sukuk Musyarakah, Sukuk Istishna’ with the method of issuing in bookbuilding, auction methods and private placement. In sukuk transactions there is a requirement for Underlying Assets as well as activities or processes which have been based in accordance with sharia. This shows that investing with sukuk is not worrying for investors who want to transact with sharia financial institutions.

Keywords: Investing, Transaction, Sukuk
Controlling Organisasi Dalam Perspektif Al-Qur’an Dan Hadits
Authors: Endah Tri Wisudaningsih
Published: February 2020

Controlling, whether in terms of supervision or control by most societies, is often interpreted as an attempt by a manager or supervisory agency as an activity to find fault. In fact, if carefully understood, the function of supervision or control is actually as one of the strengths to make improvements if the results or services that have been standardized is not in accordance with the expected results. Standardization is one of the initial actions of the planning process and that standard must be reliable and reliable as a basis for evaluating and comparing through surveillance activities. Standardization of the planning process is intended for the achievement of organizational goals or effectiveness, while supervision is more focused on the implementation process and the results of productivity, both in the form of goods or services. Monitoring efforts should be maximized so that the business results of an organization is more efficient.
Konsep Keselamatan Dalam Al-Qur'an
Authors: Salamah Eka Susanti
Published: February 2020

The doctrine of salvation is an important concept that is common to every religion. Therefore, each religion claims to be the savior (Salvator) for each of its followers. In Protestant Christianity for example, there is a doctrine known as "No Salvation Outside Christianity", beyond Christianity there is no salvation. Likewise in Catholic Christianity, adhering to, a doctrine that mentions "Extra Ecclesiam Nulla Salus", outside the church there is no salvation. For Judaizers, the doctrine of "The Chosen People" becomes their theological foundation that only Jews will gain salvation. Whereas in Islam itself, the theological argument of salvation as their own is based on the doctrine of ultimate cessionism (ie, Christianity and Judaism) remains valid before the coming of the new (Islamic) rule that replaces the old rule, the new rule by itself cancel the previous rule. This argument is based primarily on the verse (إن الد ين عند الله الاء سلام) .If historically examined, all religions without exception, both tertiary and non-theistic are born and have a claim to the truth about the assurance of salvation, whether expressed explicitly or implicitly. In other words, no religion does not have a doctrine of salvation because the claim of salvation is something that is already inherent in every religion.
Parameter Kebenaran Ilmu Pengetahuan (Sains) dalam Al-Qur’an
Authors: Ibnul Arobi
Published: February 2020

Kebenaran suatu ilmu pengetahuan benar-benar dapatdiketahui kebenarannya. Kebenaran merupakan puncak kajianepistemology yang bermuara pada metafisika. Esensi suatu kebenaranilmu adalah cocoknya informasi, atau teori dengan kenyataan objeksndiri. Dalam aspek-aspek dunia metafisis dan realitas mutlaktranscendental, parameter kebenaran itu adalah teks wahyu (al-Qur’andan Hadith) yang maknanya diketahui secara pasti menurut standarIjma’ dan logika untuk derajat “normal”. Parameter kebenaran suatuilmu pengetahuan dapat dibuktikan dalam al-Qur’an, didalamnyamemuat berbagai ilmu pengetahuan yang kebenarannya mutlakserta keasliannya yang tak dapat disangsikan lagi dan juga telahmemberikan kedudukan istimewa kepada al-Qur’an diantara kitabkitabsuci yang lain.
Islam Dan Tantangan Globalisasi
Authors: Salamah Eka Susanti
Published: February 2020

The progress of information, communication and transportation technology has had a wide influence on daily life, and even overhauled the social system. It is difficult to put the process of social, cultural and political change nowadays apart from the development of global dynamics. The process of globalization has a huge influence on the development of religious values. Religion as a view that consists of various doctrines and values has a great influence on society. They recognize the importance of the role of religion in social life - the politics of the world community. plays an important role in the process of globalization. Because of the importance of the role of religion in people's lives, it is necessary to understand the extent of religion in responding to various social problems. Religion is reduced to provide rules of life and as an instrument for understanding the world that will bring happiness to human life. In line with these changes, finally emerged three forms of fundamental paradigms that developed among Muslims in the face of globalization, namely: conservative, liberal and alternative paradigms.

Keywords: Paradigm, Islamic, Globalization.
Yevhen Tymchenko and the staff of The Commission for the Compiling of The Historical Dictionary of Ukrainian Language
Authors: Polishchuk Tetiana
Published: February 2020

The article provides biographical information on the staff of The Commission for the Compiling of The Historical Dictionary of Ukrainian Language at the UAN under the leadership of Yevhen Tymchenko.
The Musical Encyclopedia of Ukraine: achievements and challenges
Authors: Kalenychenko Anatolii
Published: February 2020

The article is devoted to the development of the musical encyclopedia publishing. The main attention is paid to the history of the creation of the Ukrainian academic musical encyclopedia, and to the problems that the author’s team overcame while working on it.
PERLUASAN MAKNA KATA SAPAAN DAENG DALAM BAHASA MAKASSAR
Authors: Tamrin Tamrin
Published: February 2020

Daeng merupakan gelar kebangsawanan suku Makassar, tetapi acap ditujukan sebagai panggilan bagi para pelaku ekonomi menengah ke bawah. Penelitian ini bertujuan untuk (1) mendeskripsikan kompleksitas penggunaan sapaan daeng di Kota Makassar dan (2) mendeskripsikan kata sapaan daeng yang banyak ditujukan kepada masyarakat pelaku ekonomi menengah ke bawah. Metode yang digunakan dalam penelitian ini adalah metode kualitatif deskriptif. Hasil analisis menunjukkan bahwa perbedaan penggunaan gelar daeng pada masa lampau dan masa sekarang dalam realitas sosial masyarakat Makassar disebabkan oleh tiga faktor yaitu (a) fleksibilitas dalam sejarah penggunaan gelar daeng yang menyebabkan luasnya makna daeng, (b) sistem kebudayaan suku Makassar yang lemah dalam memberikan batasan-batasan penggunaan gelar daeng dalam kehidupan sosial masyarakat, (c) tidak ada sebutan atau panggilan yang tepat untuk ditujukan kepada para pelaku ekonomi menengah ke bawah seperti pengayuh becak, tukang sayur keliling, dan penarik bentor yang sarat dengan nilai-nilai kesopanan dan tata krama berkomunikasi.
Сurrent legislative initiatives in the area of local self-government in the capital of Ukraine. Experience of expert analysis.
Authors: Batanov Alexander
Published: February 2020

The article deals with the status of constitutional and legal support for the realization of the status of the city of Kyiv as the capital of Ukraine, as well as the conceptual problems of the current legislative initiatives in the sphere of local self-government and executive power in the city of Kyiv, using the experience of expert analysis.

It is noted that over the years that have passed since the adoption of the legislative acts that determined the peculiarities and specifics of the organization and functioning of local self-government and executive power in the city of Kyiv, the corresponding relations have developed quite contradictory both in terms of the implementation of capital functions and activities of organizational structures of the city authorities, first of all, the Kyiv mayor, the Kyiv city council, the Kyiv city state administration, implementation of management in the districts of cities, etc.

The set of objective and subjective reasons, legal, political and socioeconomic, internal and external factors, which necessitate improvement of legislative support of the organization and functioning of local selfgovernment and executive power in the city of Kyiv, are considered.

A critical analysis of the drafts of the new version of the Law of Ukraine «On the Capital of Ukraine – Hero City Kyiv» is carried out (Reg. No. 2143 of 13.09.2019; Reg. No. 2143-1 of 19.09.2019; Reg. No. 2143-2 of 24.09.2019; Reg. No. 2143-3 of 24/09/2019). It is proved that these draft laws contain a number of conceptual shortcomings related to the regulation of metropolitan functions, the status of local self-government and executive power in the city of Kyiv, their tasks and competences, the place and role of the Charter of the territorial community of the city of Kyiv in the process of solving urban issues values, etc.

The general conclusion is that the mechanism of implementation of local self-government and executive power in the city of Kyiv is extremely contradictory and inefficient, and modern legislative initiatives in the sphere of ensuring the status of the city of Kyiv not only eliminate the existing gaps and defects, but also create new problems of political, legal and socioeconomic, functional and institutional nature.

Key words: capital of Ukraine, metropolitan functions, local selfgovernment, executive power, territorial community.
Legal regime of access to information
Authors: SEMENYUK O. , LEONOV B.
Published: February 2020

The article analyzes scientific approaches of experts in different branches of law on the concept of “legal regime”, under which general theoretic traits of this concept are derived, justifies the need of legal regulation of the general legal regime of information and the special legal regimes of information.
Problems of legal regulation and development of cyber security of Ukraine at the current stage
Authors: KOSTENKO O.
Published: February 2020

The article analyzes the problems of legislative regulation of the sphere of cyber security in Ukraine based on the experience of modern cyber threats and cyber attacks that have been carried out on state information resources in recent years. Critical areas in which information systems were the most vulnerablehave to cyber-attacks have been investigated. The problem of conceptual and categorical apparatus of the basic regulatory legal acts of the sphere of cyber security is covered, as well as digital signature and lack of correlation of cybercrime with the legal liability of subjects for cyber-security offenses. Recommendations on taking appropriate measures in the field of cyber security of Ukraine at the present stage are offered.
Information protection by enhancing the effectiveness of counteracting cyber attacks
Authors: GAVLOVSKI V.
Published: February 2020

The article deals with some aspects of information security by enhancing the effectiveness of counteracting cyber attacks. The State of Implementation of the NSDC Decision on Delimitation of the Continuity of Investigation of Cybercrimes is analyzed.