bluuebunny/crossref_metadata_2025 huggingface dataset:
Clonal Evolution of Aplastic Anemia: A Brief Literature Review and a Case Report
Authors: Shilova Elena Romanovna , Glazanova T.V. , Kostroma I.I. , Zenina M.N. , Rozanova O.E. , Chubukina Zh.V. , Sabitova R.R. , Romanenko N.A. , Balashova V.A. , Gritsaev S.V.
Published: July 2022

Aplastic anemia (AA) is a non-neoplastic hematological disease closely associated with bone marrow failure which is typical of paroxysmal nocturnal hemoglobinuria (PNH) and myelodysplastic syndrome (MDS). The PNH clones can be detected in more than a half of AA patients at onset of the disease, and there is a probability for AA/PNH co-variants to progress to classic hemolytic PNH. At the same time, the AA patients treated by immunosuppressive therapy undergo the risk of disease transformation to MDS and acute myeloid leukemia. Currently known risk factors and possible precursors of such transformation are considered in the brief literature review. In addition to that, the paper provides a case report of AA/PNH transformation to MDS during complete AA remission after immunosuppressive therapy combined with a successful haploidentical transplantation of hematopoietic stem cells.
LESION VERRUQUEUSE ATYPIQUE DU PLANCHER BUCCAL : HYPERPLASIE VERRUQUEUSE OU CARCINOME VERRUQUEUX ?
Authors:   Department of Plastic and Maxillofacial Surgery, Mohammed V Military Hospital, Mohammed V University, Rabat, Morocco., EL Hafidi Nawfal , Azzakhmam Mustapha ,   Department of pathology, Mohammed V Military Hospital, Mohammed V University, Rabat, Morocco., MFA Keith ,   Department of Plastic and Maxillofacial Surgery, Mohammed V Military Hospital, Mohammed V University, Rabat, Morocco., Bakhil Ayoub ,   Department of Plastic and Maxillofacial Surgery, Mohammed V Military Hospital, Mohammed V University, Rabat, Morocco., Khalfi Lahcen ,   Department of Plastic and Maxillofacial Surgery, Mohammed V Military Hospital, Mohammed V University, Rabat, Morocco., El Khatib Karim ,   Department of Plastic and Maxillofacial Surgery, Mohammed V Military Hospital, Mohammed V University, Rabat, Morocco.
Published: July 2022

Lhyperplasie verruqueuse est une lesion verruco-papillaire rare de la muqueuse buccale, potentiellement maligne avec une tendance a se transformer en son homologue malin, le carcinome verruqueux.Elle est cliniquement indiscernable, mais histologiquement variable. Lhyperplasie verruqueuse buccale possede des caracteristiques enigmatiques qui rendent le diagnostic tres difficile, notamment du fait quelle peut cliniquement ressembler a dautres lesions verruco-papillaires de la muqueuse buccale. Par consequent, une approche protocolisee, au moyen de criteres cliniques et histologiques standardises, doit etre executee pour differencier lhyperplasie verruqueuse buccale des autres lesions verruqueuses et papillaires de la muqueuse buccale afin de choisir loption therapeutique la plus adaptee. Ce travail presente une hyperplasie verruqueuse atypique du plancher buccal chez une femme de 80 ans.
A study on Biodiesel Characteristics of Tea Seed Oil extracted using Supercritical CO₂ Extraction
Authors:   Association for International Tea Culture, Choi Dubok , Choi On-you , Yu Kwan-jong
Published: July 2022

The purpose of this work was to examine the reaction time, reaction temperature, catalyst, and mixing ratio of methanol and Ungpo tea seed oil extracted from supercritical CO2 extraction method for optimization of the biodiesel production process variables. The optimum conditions for effective biodiesel production were obtained at 50 min of reaction time, 60°C of reaction temperature, 1.0% of KOH as catalyst, and mixed molar ratio 1:5 of tea seed oil and methanol, respectively. For evaluation of biodiesel produced from the optimum conditions, physicochemical properties were measured. Biodiesel production yield was a range of 97.14 and 97.79%. In the case of density, it was a range of 0.83 to 0.84, which was similar to standard value. When Ungpo tea seed oil's biodiesel was used, the iodine value was 111.25 g I2/100 g, which was about 5.4% lower than Jeju tea seed oil's biodiesel. Oxidative stability of Ungpo tea seed oil's biodiesel was found to be 7.58 hr, which was about 5.0% lower than Jeju tea seed oil. However, compared to the EU's biodiesel quality standard, it was increased by about 20.3%. CFPP of Ungpo tea seed oil's biodiesel was found to be -8.38 ∼ -7.84℃, which was almost similar as that of Jeju tea seed oil's biodiesel. These results indicated that Ungpo tea seed oil exracted from supercritical CO2 extraction might be a suitable raw material for the biodiesel production.
Estimation of parameters of genetic variation of spring durum wheat (Triticum durum Desf.) on the basis of “number of grains from the main spike”
Authors: Kuzmenko Ye. A. , Pirych A. V. , Fedorenko M. V.
Published: July 2022

Aim. To assess the combining ability, features and nature of the inheritance of the trait “number of grains from the main spike” in varieties of spring durum wheat for their further involvement in breeding programs.
Methods. The investigations were carried out at the V. M. Remeslo Institute of Wheat of NAAS of Ukraine. Varieties (‘Zhizel’, ‘MIP Raiduzhna’, ‘Kharkivska 27’, ‘Kharkivska 39’, ‘Spadshchyna’, ‘Kuchumovka’, ‘Tera’) of domestic breeding were involved in crossings according to the full diallel scheme (7 ´ 7). Parental components and F1 were studied in the field in 2016, 2017.
Results. The analysis of variance of combining ability showed a significant advantage in general combining abili­ty (GCA) effects. The mean square of the specific combi­ning ability (SCA) was significantly inferior to the GCA, but was significant in both years of the study. Consistently high GCA effects in 2016, 2017 were determined in the variety ‘Tera’ (gi = 1.35; 2.37). Non-alelic gene interaction was not found, which made it possible to analyze the main parame­ters of genetic variation. In two years of investigations, in the phenotypic manifestation of the number of grains from the main spike, dominant effects (H1 and H2) survived over additive ones (D). The average degree of dominance indicated overdominance (H1/D). The indicator of the ave­rage degree of dominance in loci () also indicated overdominance. Dominance was significantly oriented. Dominant effects of genes increased the number of grains, while recessive effects decreased them. At least one group of genes has been identified that has led to dominance. In general, dominant genes (F > 0) or groups of genes dominated quantitatively in cultivar investigated. A high coefficient of heritability in a broad sense (H2 = 0.88; 0.90) indicates a significant phenotypic conditionality to genetic factors. The coefficient of heritability in a narrow sense (h2 = 0.31; 0.38) indicates the average contribution of the additive effects of genes over the dominant ones.
Conclusions. The identified breeding and genetic features on the basis of the “number of grains from the main spike” trait make it possible to predict the effectiveness of selections aimed at increasing the trait in the newly hybrid material. However, due to the predominance of dominant effects and overdominance in the genetic control of a trait, selection in later generations will be more effective. Varieties ‘Kharkivska 27’, ‘Kharkivska 39’ and ‘Tera’ should be used as genetic sources to increase the trait “number of grains from the main spike”.
Significance of sources of valuable traits for cotton breeding
Authors: Borovyk V. O. , Vozhehova R. A. , Marchenko T. Yu. , Boiarkina L. V. , Khomenko T. M.
Published: July 2022

Purpose. Select valuable samples from the collection of cotton on the basis of “number of open bolls per plant” and “weight of raw cotton from one boll” for further use in the breeding process when creating new varieties and their impact on productivity.
Methods. During 2002–2019 on the fields of selection crop rotation of the selection department of the Institute of Irrigated Agriculture of the National Academy of Sciences, 282 samples of cotton of different ripeness groups were studied.
Results. Among the stu­died cotton gene pool, in 20.4% of samples, the number of bolls per plant was very small – < 65–75%, in 26.8% – small, in the remaining (52.8%) samples, an average number of open bolls was formed. The analysis of the boll mass indicators showed that 16.0% of the samples had a very small boll (less than 3.0 g), most of the collection – 66.0% had a small boll (3–4 g); average (5.0–6.0 g) – 18.0%. It was revealed that there is the most significant direct relationship between the productivity of samples and the number of open bolls per plant. The equation for the correlation-regression dependence of the productivity of one plant on the number of open bolls per plant is: y = 0.1807x – 0.5292; Coefficients: R2 = 0.852; r = 0.923. A direct positive dependence was observed in the samples of UF080000 ‘Pidozers­kyi 4’, UF0800027 ‘Populiatsiia 3’, UF0800241 ‘Populiatsiia 9’, UF0800029 ‘417 U’, UF0800228 ‘3737 U’, UF08000 ‘K 71’, UF0800056 ‘Mariia’, UF0800206 ‘1086/94’. The maximum productivity, from 45.0–49.2 g, was noted in the early matu­ring samples of the collection, compared with varieties that had a long vegetation period and productivity from 33.0 to 43.0 g. The excess over the standard is from 2.5 up to 6.7 g and from 9.5 to 0.5 g/plant, respectively.
Conclusions. For the first time in the conditions of the Southern Steppe, the most significant direct relationship between the producti­vity of genotypes and the number of open bolls per plant was revealed – r = 0.923. The maximum productivity – from 45.0 to 49.2 g – was observed in early maturing samples of the collection. In the course of many years of cotton gene pool research, sources of valuable traits were identified.
Evaluation of productivi­ty of different varieties of soryz (Sorghum orysoidum)
Authors: Voitovska V. I. , Storozhyk L. I. , Liubych V. V. , Yalanskyi O. V.
Published: July 2022

Aim. To establish the features of productivity formation (yield, protein and gluten content and estimated yield of bioethanol) of different varieties of soryz.
Methods. Experimental studies were conducted during 2019–2021 at the Experimental Field of the Institute of Bioenergy Crops and Sugar Beets of the National Academy of Sciences of Ukraine (Ksaverivka 2, Bila Tserkva District, Kyiv Region). Yields were determined by direct combining in sections, protein and starch content by infrared spectroscopy, and possible bioethanol yield by starch content.
Results. On average, over the years of research, the highest yields were observed in the cultivar ‘Fakel’ – 10.93 t/ha, the lowest – in ‘Helios’ and ‘Saliut’ – 7.97 and 8.82 t/ha, respectively. The yield of other varieties was 9.38–9.82 t/ha, while the stability index, depending on the cultivar, varied from 0.77 to 0.90. The hi­ghest protein content in seeds was found in the variety ‘Samaran 6’ (14.0%), the lowest – in ‘Oktan’ (12.7%) and ‘Merkurii’ (12.4%). In other varieties of soryz this figure ranged from 13.1 to 13.9%. The stability index of the protein content was high – 0.91–0.97. It was found that the cultivation of soryz varieties ‘Evropa’, ‘Tytan’, ‘Samaran 6’ and ‘Fakel’ allows to obtain the highest estimated yield of bioethanol – 4027–4630 kg/ha. The lowest indicator was in the variety ‘Helios’ – 2846 kg/ha. For other varieties, this figure was at the level of 3378–3861 kg/ha. It should be noted that the grain of all soryz varieties must be dried after harvest, as its humidity, even in more favorable weather conditions is 16.2–21.4%.
Conclusions. Soryz productivity varies greatly depending on the variety and weather conditions. All varieties provided high yields – 7.97–10.93 t/ha. For the production of food grain with a protein content of 13.1–13.8%, it is recommended to use varieties of ‘Kvarts’, ‘Helios’, ‘Saliut’ and ‘Odeskyi 302’. For the production of food grain (protein share 13.9–14.2%) and obtaining a high yield of bioethanol (3478–5265 l/ha) it is necessary to use varieties ‘Evropa’, ‘Tytan’, ‘Samaran 6’ and ‘Fakel’.
Telemedicine as one of the directions of innovative technologies in Ukraine
Authors: Korobtsova N.
Published: July 2022

The emergence and development of the latest innovative information technologies have affected all areas of human activity, including medicine. Unsatisfactory health care for people living in remote and rural areas, the need for emergency medical care, the spread of the SARS-CoV-2 coronavirus pandemic in the acute respiratory disease COVID-19, and the impetus for war telemedicine in Ukraine. Telemedicine is becoming an alternative to direct visits to the doctor, saves time and money of the patient, while receiving timely quality medical services. Despite certain pitfalls and obstacles to its development (weak Internet coverage and imperfect technical equipment, ignorance of medical staff in this method of treatment, economic barriers, lack of proper legal support, mental barriers, etc.), the number of people who use this method of providing services, is growing every day. Ukraine, in contrast to Europe and the world, where telemedicine has long been commonplace, today is only taking the first steps to implement this method in health care, which makes this study relevant.The aim of the article is to consider telemedicine as one of the relatively new methods (ways) of providing medical services in Ukraine where distance is a critical factor. We are talking about the use of the latest innovative information and communication technologies for the purpose of providing medical care to the population, namely: diagnosis, treatment, prevention of diseases, including the exchange of experience between doctors "at a distance". The state and level of development of telemedicine in European countries and the world are considered, the positive aspects of its implementation are investigated, which are: the possibility of obtaining a wide range of medical services, spending much less time visiting a doctor; the consultant doctor has the necessary information about the patient, thanks to the digital format of medical records, which significantly speeds up his treatment and eliminates the likelihood of medical error; availability of medical services for the population living in areas where there is a shortage of doctors; the ability to receive emergency medical care, especially in pandemics, martial law and emergencies; providing assistance to medical staff by involving other specialists, creating a council; as well as obtaining a "second" opinion of a specialist to correctly diagnose or treat the patient.The current and future national legislation on the research topic is analyzed. The stages of introduction of telemedicine in health care institutions of Ukraine are determined and considered.
Malicious Use of Artificial Intelligence Discussed in the Framework of the XIII International IT-forum.
Authors:   International Center for Social and Political Studies and Consulting, Matyashova D.О.
Published: July 2022

Development of the new technologies in the sphere of artificial intelligence and expanding their application for our everyday life supposes large-scale social and political consequences on the national and global levels. The mentioned above consequences are reflected on cooperative interactions like mutual development of strategies on the level of interstate associations, creating ethical codes of artificial intelligence as well as taking into account destructive tendencies of application of artificial intelligence by terrorist organizations, extremists and conflicting states. It also can be applied for malpractice and social opinion manipulation from the side of transnational IT-corporations etc. The pace of development and spreading of artificial intelligence by users demand, besides comprehension of current trends, prognosis of its dynamics and content taking into account international political and economic challenges that modern society faces. The suggested review of the conference presents the results of the mentioned comprehension and prognosis that were announced by reputable experts in the area of political, legal and technical sciences in the frame of the conference on the basis of XIII International IT-Forum with BRICS and SCO participation.
Criminalistic Aspects of Production of Visual-Figurative Methods of Evidence Recording
Authors:   Moscow State University  named after M. V. Lomonosov, Egorov N.N.
Published: July 2022

The author analyses the process of proving as gathering, checking, evaluating and using the evidence in the purpose of determining the circumstances that have to be proven. It means that the author views the process of proving somewhat broader than it is cited in the Article 85 of the Criminal Law Code of the Russian Federation. The recording is the second element of the evidence gathering after they have been searched for and found. The author analyses the classification of the evidence recording. It can be of two kinds: obligatory or prescribed by the Criminal Procedure Law and optional or recommended by law (with regard to Criminal Procedure Law); the classification also divide them on subjective or depending on the qualities of the personality of the subject who record the evident. In this case his or her knowledge, skills and professional experience is taken into account. Objective, on the other hand, are based on physical, chemical or other processes (these processes are the basis of the recording). The article pays close attention to the means of the recording of evidence, especially to photo and video recording as these are the graphic ways to record evidence that are frequently used in practice. The author specifies that the content of the systems of methods of forensic and investigative photography implies including into it panoramic shooting, measuring, reproduction, identification photography and macro photography. Modern technical equipment and software for video recording allow to perform high-speed and slow-motion video shooting that can be viewed as special technical means that can be used while conducting examinations and some investigative actions.
Identification of pathways that lead to continuous or intermittent water supply by conducting a qualitative comparative analysis of rural water utilities in China
Authors: Tong Yan , Fan Liangxin , Niu Haipeng
Published: July 2022

Ensuring a continuous water supply (CWS) for households is beneficial for the current global drinking water, sanitation, and hygiene agenda. Despite improvements in water supply, intermittent water supply (IWS) remains prevalent in rural areas. To determine the factors that lead to different water supply modes for villages, we select 38 village-level water utilities covered by the Chinese Safe Drinking Water Project for fuzzy set qualitative comparative analysis to identify causal configurations (‘pathways’) that lead to IWS or CWS across systems. Six configurations of water supply mode are identified on the basis of the outcomes of each case. Among these, three configurations for adopting CWS are determined. Configuration 1 features water utility with government subsidy and bills using a water meter. Configuration 2 features water utility with small population coverage, government subsidy, and villager participation in the management. Configuration 3 features a water utility collectively managed and owned by a rich village and water-saving initiatives. Configurations that lack meter-based bills, government subsidies, and water-saving initiatives are the main paths for IWS. Results highlight the uniqueness of the configurational approach in understanding different water supply patterns across various cases and emphasise the importance of government subsidies, villager participation, water-saving programmes, and water meter-based billing to achieve CWS.
Characteristics of the water cycle of Jinan karst spring in northern China
Authors: Deng Xing , Xing Liting , Yu Miao , Zhao Zhenhua , Li Changsuo , Su Qingwei
Published: July 2022

Due to the multi-scale nature and complexity of the flow field, it has always been difficult for hydrogeologists to accurately grasp the water cycle characteristics of the karst water flow system. The inverse statistical model and IsoSource model were employed to calculate the spring age and the mixing ratio of spring recharge sources of the four large spring groups in Jinan. The karst hierarchical groundwater flow system was identified based on multiple factors. We found that the groundwater ages of Baotu Spring and Heihu Spring are about 6a–10a, and those of Wulongtan Spring and Pearl Spring are about 30a–35a. The main recharge sources of spring water of the four large spring groups were recognized as artificial recharge water, Ordovician karst water, and Cambrian Zhangxia Formation karst water. There were distinct differences in the recharge proportion of the four large spring groups. Three groundwater flow systems were identified according to multiple factors, which were local, intermediate, and regional. Furthermore, different levels of groundwater flow systems were recharged to the four large spring groups in different proportions. The research results provided new insights into the analysis of the hierarchical cycle and evolution of karst water.
Quantification of soil erosion in small watersheds on the Loess Plateau based on a modified soil loss model
Authors: Kong Hui , Wu Dan , Yang Liangyan
Published: July 2022

The technology of slope vegetation system stability enhancement is an important part of the comprehensive ecological security improvement in small watersheds area of the Loess Plateau. The results of the comprehensive soil erosion improvement in the sub-basin are used to give an evaluation of the effectiveness of the gully slope vegetation restoration project. Soil erosion quantification distribution in the Sheep Sap Gully sub-basin of the Loess Plateau hilly gully area was simulated and explored by combining the modified universal soil loss equation RUSLE model with GIS and RS spatial information technology. The quantitative values of LS factor were extracted using DEM data, the R factor of rainfall erosion force was calculated using meteorological monitoring station data around this region, the K factor of erosion resistance was obtained based on the soil survey database, and the C factor and P factor of soil and water conservation measures were obtained by combining MODIS image data and previous research experience. The study concluded that (1) The erosion area ratio within the study area is 36.33%; (2) The quantitative grading standard of the pattern, the size of the erosion distribution area at all levels is ranked as light>moderate>very strong>strong>intense; (3) Under the conditions of land use and vegetation cover, strong erosion is mostly found in farming areas with sparse vegetation, while weak erosion is found in areas with lush vegetation such as forests and grasslands; (4) In terms of spatial distribution, erosion is greater in the south-western part of the basin than in the north-eastern part, and there is also strong erosion in the south-western part. The results of the study provide a reference for research into integration and synthesis of ecological security technologies for gully and slope management projects. The research content provides the basis and support for watershed governance and soil and water resource management and conservation.
ANÁLISIS DEL COMPORTAMIENTO DE LAS VARIABLES BIÓTICAS DE LA RESERVA NACIONAL DE LACHAY AL EVENTO EL NIÑO (1998-2001, 2010)
Authors: Castañeda Córdova Liz Zaida , Sánchez Infantas Edgar Hugo , Quinteros Carlos Zulema Diana
Published: July 2022

El presente estudio nace del interés de generar una alerta temprana biológica frente al Evento El Niño, tomando como base los estudios de las herbáceas, las aves y los coleópteros que se realizaron entre 1998 al 2001 en la Reserva Nacional de Lachay. El presente estudio incorporó para el año 2002 dos muestreos para coleópteros y para el año 2010 dos muestreos para cada grupo. El objetivo de la investigación fue evaluar la variación de las variables bióticas de los tres grupos biológicos bajo el Evento El Niño entre 1998-2001 y 2010, para identificar variables indicadoras del Evento El Niño. En las parcelas se estimó la composición, la abundancia, la diversidad, los grupos funcionales para cada grupo. Adicionalmente para las herbáceas se evaluó la cobertura vegetal, la densidad, el IVI y el Cinv. Algunas variables (Cinv Abundancia, Cinv Cobertura, Cinv IVI nativas y/o endémicas y la cobertura vegetal) sugieren una relación positiva con el Niño Global porque se incrementan luego de su manifestación, desde un Evento El Niño muy fuerte a un Niño moderado, propiciando la aparición de especies herbáceas endémicas. Otras variables propuestas para su monitoreo son la abundancia y riqueza de los coleópteros, la diversidad alfa y riqueza de las aves; de los grupos funcionales el porcentaje de abundancia de caméfitas, el porcentaje de abundancia de nanofanerófitas y la abundancia del grupo depredador. Algunas especies clave como Croton ruizianus, Trixis cacalioides, Crassula connata, Fuertesimalva peruviana, Nicotiana paniculata y como variable clave el IVIg.
Crowdfunding Publishing Model Study : Based on the case of Tumblbug in 2021
Authors:   The Korean Publishing Science Society, Kong Byoung Hun , Cho Jung Mi
Published: July 2022

This study analyzed the characteristics and models of crowdfunding publishing, which is being activated in the changed media environment, through case analysis and depth interviews. In crowdfunding publishing, the writer/author proposes a project and forms a community relationship by participating in the proposed project as a sponsor, performing a publishing process called planning, creation, publication, promotion, and distribution. The crowdfunding platform acts as a hub that connects authors and readers and activates publishing activities to operate the publishing value network. The author, writer, and reader community on the crowdfunding platform plays a key role in the system of spreading projects through social networks and developing and virtuous cycle of products and non-product books through interaction among participating actors.
A Study on the publication of translations of Western classics : An example of translation of Goethe's The Sorrows of Young Werther
Authors:   The Korean Publishing Science Society, Song Duk Ho
Published: July 2022

The need to read classics is growing day by day. It is necessary to check once in a while how faithfully translated and disseminated the 'World Literary Collection', which has spread like a fad in the publishing world. In this thesis, readers' translation criticism was attempted on Goethe's The Sorrows of Young Werther, which is a classic literary work common to all world literature collections in Korea. Checking the translation from the point of view of a reader who does not know the foreign language of the starting text is a criticism about the publisher's publication of the translated book. Therefore, unlike the existing translation criticism method, the translation status was reviewed targeting the same works of five publishers publishing world literature collections based on ‘readability’ and ‘consistency’, ‘omission error’ and ‘notation error’. As a result, all translations of the five publishers are incomplete, so it seems urgent to prepare a countermeasure for the translation of Western classics. The solution is a world-class translation project led by the state. Another way is to expand and reorganize the Korean Classics Translation Institute into the World Classics Translation Institute. As history proves, the promotion of the humanities is achieved through translation projects.
Designing Potential Antitrypanosomal Thiazol-2-ethylamines through Predictive Regression Based and Classification Based QSAR Analyses
Authors: Amin Sk. Abdul , Adhikari Nilanjan , Bhargava Sonam , Jha Tarun , Gayen Shovanlal
Published: July 2022

Background: Thiazol-2-ethylamine is recently reported to be an interesting
scaffold having antitrypansomal activity for the treatment of sleeping sickness.

Methods: Statistically significant, robust and validated regression-based QSAR
models are constructed for a series of antitrypansomal thiazol-2-ethylamines.
Moreover, classification-based QSAR analyses (linear discriminant analysis and
Bayesian classification modelling) are also performed to identify the important
structural features controlling antitrypanosomal activity.

Results: Molecular fingerprints such as N-piperidinyl and 2-fluorophenyl functions
may be responsible for higher antitrypanosomal activity whereas compounds with
chlorophenyl moiety and compounds with unsaturated nitrogen atom possess poor
activity. These results are supported by the regression-based QSAR model as well as
the SAR observations.

Conclusion: Finally, fifteen new compounds bearing thiazol-2-ethylamine scaffold
are designed and predicted along with their drug-likeness properties. Therefore, this
study may provide important structural aspects of designing new antitrypansomal
agents with higher activity.
Reading-writing in the development of text in the students of the Dr. “Aquiles Valencia” School
Authors: Mendoza-Intriago Geoconda Ondina , Andrade-Zambrano Carmen Dolores
Published: July 2022

The research had the purpose of determining the reading-writing in the development of text in the students at the School of Basic Education Dr. Aquiles Valencia. In this sense, the general objective was to analyze literacy in the development of text in the students of this educational institution. The investigative approach was quantitative, allowing the recovery, analysis, and assessment of information, through surveys and the analysis of statistical results. As a result, it is proposed that, because it is a segment of the population with limited economic resources, the academic level of the parents does not help to collaborate with their children. The methodologies of the teachers, it is considered that in the medium term the literacy deficit will not be reduced.
Controlling Supplier Supply Stability with High Demand During the Covid-19 Pandemic at PT PQS
Authors: Santoso Sugeng , Anjela Lia , Alvionita Uci , Firmansyah Firmansyah , Etlanda Khoirul Akbar , Fatmawati Ari Ana
Published: July 2022

COVID-19 with a snap into a very influential factor in all sectors of the economy worldwide. The decrease in demand is also strongly felt in the manufacturing sector in Indonesia, even there are some factories were forced to have to lay off thousands of employees because it is not able to pay the salaries of employees. The opposite condition was experienced by PT PQS Indonesia, which experienced an increase in demand by 40% compared to the average demand for 6 months before COVID-19, because some of the company's branches in other countries had stopped production because they had to follow local government policies. Eventually all orders were sent to be produced at PT PQS Indonesia. The increase in demand does not mean that PT PQS Indonesia did not experience obstacles during the COVID-19 pandemic, the problem faced was the decline in delivery performance from suppliers, which impacted on the reduced stock of raw material stock and could even lead to production stops. This is because the suppliers were affected by Covid-19. This is a challenge because PT PQS has dozens of suppliers at home and abroad. To repeat this so that production does not stop, PT PQS Indonesia added a feature to help control supplier delivery performance. In 2018 the average delivery performance is only 60% — 70%, and the management target is 90% for local suppliers and 85% for overseas. This “Supplier Delivery Performance” feature really helps the procurement team to control the arrival of goods and provide information to suppliers related to their delivery performance, as well as being one of the index KPIs to evaluate supplier performance for one year before the Annual Vendor Meeting is held. To create a “Supplier Delivery Performance” index, PT PQS must also create SOPs or standardize them so that all relevant suppliers and procurement teams can easily understand them. 
The adaptive science communication model in the middle of VUCA era in Indonesia: Study of startup Kok Bisa
Authors: Putri Syora Alya Eka , Adnan Ricardi S
Published: July 2022

This article analyzes the adaptive science communication model in the VUCA era. Previously, the model of science communication developed by scientific institutions and journalists in Indonesia tended to be challenging to understand by the public. Finally, in the development of technology, the model of science communication developed marked by the emergence of various creators who utilize social media. Nevertheless, due to dynamic conditions, the development of science communication models has not been fully adaptive. In previous studies, these conditions due to dynamic challenges due to the lack of public confidence in science and community participation to curate science tend to be slow in the rapid dissemination of information. This study uses a qualitative approach with case studies of digital data analysis. This study shows that the science communication model can develop more adaptively during disruptive conditions with innovations in social media from the form of presentation and inviting cooperation with other parties, as well as to conduct transformative strategies by building organizational resilience, developing valid information, restructuring, and conducting experiments following organizational capabilities.
Language Use in Conversational Agent–Based Health Communication: Systematic Review
Authors: Shan Yi , Ji Meng , Xie Wenxiu , Qian Xiaobo , Li Rongying , Zhang Xiaomin , Hao Tianyong
Published: July 2022

Background

Given the growing significance of conversational agents (CAs), researchers have conducted a plethora of relevant studies on various technology- and usability-oriented issues. However, few investigations focus on language use in CA-based health communication to examine its influence on the user perception of CAs and their role in delivering health care services.

Objective

This review aims to present the language use of CAs in health care to identify the achievements made and breakthroughs to be realized to inform researchers and more specifically CA designers.

Methods

This review was conducted by following the protocols of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 statement. We first designed the search strategy according to the research aim and then performed the keyword searches in PubMed and ProQuest databases for retrieving relevant publications (n=179). Subsequently, 3 researchers screened and reviewed the publications independently to select studies meeting the predefined selection criteria. Finally, we synthesized and analyzed the eligible articles (N=11) through thematic synthesis.

Results

Among the 11 included publications, 6 deal exclusively with the language use of the CAs studied, and the remaining 5 are only partly related to this topic. The language use of the CAs in these studies can be roughly classified into six themes: (1) personal pronouns, (2) responses to health and lifestyle prompts, (3) strategic wording and rich linguistic resources, (4) a 3-staged conversation framework, (5) human-like well-manipulated conversations, and (6) symbols and images coupled with phrases. These derived themes effectively engaged users in health communication. Meanwhile, we identified substantial room for improvement based on the inconsistent responses of some CAs and their inability to present large volumes of information on safety-critical health and lifestyle prompts.

Conclusions

This is the first systematic review of language use in CA-based health communication. The results and limitations identified in the 11 included papers can give fresh insights into the design and development, popularization, and research of CA applications. This review can provide practical implications for incorporating positive language use into the design of health CAs and improving their effective language output in health communication. In this way, upgraded CAs will be more capable of handling various health problems particularly in the context of nationwide and even worldwide public health crises.
The Impact of Cognitive Function on Virtual Reality Intervention for Upper Extremity Rehabilitation of Patients With Subacute Stroke: Prospective Randomized Controlled Trial With 6-Month Follow-up (Preprint)
Authors: Leng Yan , Lo Wai Leung Ambrose , Mao Yu Rong , Bian Ruihao , Zhao Jiang Li , Xu Zhiqin , Li Le , Huang Dong Feng
Published: July 2022

BACKGROUND

Stroke is among the leading causes of long-term disability worldwide. Motor impairments after stroke not only impact the individuals quality of life but also lay substantial burdens on the society. Motor planning is a key component of cognitive function that impacts motor control. Hand movements such as grasping or reaching to grasp require the application of correct force and the coordination of multiple limb segments. Successful completion of hand motor task requires a certain degree of cognitive function to anticipate the requirement of the task. Cognitive function may thus be a confounding factor to rehabilitation outcomes.

OBJECTIVE

This study aims to explore the impact of cognitive function on functional outcomes in people with subacute stroke after VR intervention.

METHODS

Patients with stroke were first stratified into cognitively normal (CN) and cognitively impaired (CI), followed by allocation to the VR or control group (CG). Fugl-Meyer Assessment for Upper Extremity (FMA-UE), Barthel Index (BI), and Instrumental Activities of Daily Living (IADL) were recorded at baseline, 3 weeks after the intervention, and 3 and 6 months after the intervention. The between-group and within-group differences were assessed by repeated-measures analysis of variance (ANOVA).

RESULTS

The between-group comparison indicated that FMA-UE, BI, and IADL (time effect P<.001 for all) scores improved significantly in both groups after the intervention. Repeated-measures ANOVA indicated that FMA-UE, BI, and IADL (time effect P<.001 for all) were significantly different in each subgroup after the intervention. For BI score, the ANOVA results showed obvious interaction effects (treatment × time × cognitive effect, P=.04).

CONCLUSIONS

VR intervention was as effective as traditional conventional therapy in improving upper limb function regardless of the cognitive functional level. Patients with stroke with impaired cognitive function may gain more improvement in upper limb function and independency in performing activities of daily living after a VR-based intervention.

CLINICALTRIAL

Chinese Clinical Trial Registry ChiCTR-IOC-15006064; https://tinyurl.com/4c9vkrrn
Preliminary Real-World Evidence Supporting the Efficacy of a Remote Neurofeedback System in Improving Mental Health: Retrospective Single-Group Pretest-Posttest Study (Preprint)
Authors: Whitehead Jocelyne C , Neeman Ron , Doniger Glen M
Published: July 2022

BACKGROUND

Neurofeedback training (NFT) has been shown to be effective in treating several disorders (eg, attention-deficit/hyperactivity disorder [ADHD], anxiety, and depression); however, little is currently known regarding the effectiveness of remote NFT systems.

OBJECTIVE

This retrospective study provides real-world data (N=593) to assess the efficacy of app-based remote NFT in improving brain health and cognitive performance.

METHODS

Improvement was measured from pre- to postintervention of in-app assessments that included validated symptom questionnaires (the 12-item General Health Questionnaire, the ADHD Rating Scale IV, the Adult ADHD Self-Report Scale, the 7-item Generalized Anxiety Disorder scale, and the 9-item Patient Health Questionnaire), a cognitive test of attention and executive functioning (ie, continuous performance task), and resting electroencephalography (EEG) markers. Clinically significant improvement was evaluated using standard approaches.

RESULTS

The greatest improvement was reported for the anxiety questionnaire, for which 69% (68/99) of participants moved from abnormal to healthy score ranges. Overall, adult and child participants who engaged in neurofeedback to improve attention and executive functions demonstrated improved ADHD scores and enhanced performance on a cognitive (ie, response inhibition) task. Adults with ADHD additionally demonstrated elevated delta/alpha and theta/alpha ratios at baseline and a reduction in the delta/alpha ratio indicator following neurofeedback.

CONCLUSIONS

Preliminary findings suggest the efficacy of app-based remote neurofeedback in improving mental health, given the reduced symptom severity from pre- to postassessment for general psychological health, ADHD, anxiety, and depression, as well as adjusted resting EEG neural markers for individuals with symptoms of ADHD. Collectively, this supports the utility of the in-app assessment in monitoring behavioral and neural indices of mental health.
Impact of COVID-19–related Isolation on Individuals in Treatment for Substance Use (Preprint)
Authors: Ondrusek Ashlin Ripley , Townsend Emily , Warnock Charles , Lowe Sarah , Muilenburg Jessica , Kershaw Trace
Published: July 2022

BACKGROUND

For individuals in treatment for substance use, supportive social networks are essential to protect against a return to use.

OBJECTIVE

This study aimed to explore the impact of the swift and severe isolation brought on by the COVID-19 pandemic, specifically for individuals in treatment for substance use disorder, by exploring the relationships amongst social connectedness and isolation to treatment accessibility, mental health, and substance use.

METHODS

A total of 24 semistructured interviews were conducted from May 2020 to August 2020 with participants engaged in substance use treatment asking about the impact of the pandemic on social networks, substance use, access to treatment, and mental health. Interviews were coded and analyzed using grounded theory.

RESULTS

Results centered around two main themes: (1) access to support (eg, formal and informal networks) and (2) individual outcomes regarding substance use and worsened mental health.

CONCLUSIONS

This research suggests that the COVID-19 pandemic has greatly disrupted access to resources for individuals in treatment for substance use, and calls for treatment centers and governing bodies to put more resources into telehealth and alternative treatment plans in the event of major disruptions, such as national disasters and global pandemics.
An occupational therapist-led vocational intervention for people with stroke: study protocol for a single-centre individually-randomised controlled pilot trial (Preprint)
Authors: O'Keefe Sophie , Radford Kathryn , Farrin Amanda , Oakman Jodi , Alves-Stein Serena , Cloud Geoffrey , Douglas Jacinta , Stanley Mandy , Lannin Natasha
Published: July 2022

BACKGROUND

Resuming work after stroke is a common goal of working-age adults, yet there are few vocational rehabilitation programs designed to address the unique challenges faced following stroke. The WORK intervention was developed to address these gaps.

OBJECTIVE

This study aims to test the WORK intervention, by piloting the intervention and trial processes.

METHODS

The WORK trial is a two-arm prospective randomized, blinded-assessor study design with intention to treat analysis. Fifty-four adults of working age who have experienced a stroke <4 months prior, will be randomized 1:1 to either (i) experimental group who will receive a 12-week early vocational intervention (WORK intervention) plus usual clinical rehabilitation, or (ii) control group who will receive only their usual clinical rehabilitation.

RESULTS

Outcomes include study and intervention feasibility and intervention benefit. In addition to evaluating the feasibility of delivering vocational intervention early after stroke, benefit will be assessed by measuring rates of vocational participation and quality of life improvements at 3- and 6-months follow-up. Process evaluation using data collected during the study, as well as post-intervention individual interviews with participants and surveys with trial therapists will complement quantitative data

CONCLUSIONS

The results of the trial will provide details of the feasibility of delivering the WORK intervention embedded within the clinical rehabilitation context and inform future trial processes. Pilot data will enable a future definitive trial so as to determine the clinical effectiveness of vocational rehabilitation when delivered in the early sub-acute phase of stroke recovery.

CLINICALTRIAL

www.anzctr.og.au ACTRN12619001164189, Date registered 20/08/2019
Робота м’язів нижньої кінцівки за умови згинальної контрактури колінного суглоба
Authors: Fishchenko V.O. , Obeidat Khaled Jamal Saleh
Published: July 2022

Актуальність. Згинальна контрактура колінного суглоба — патологічний стан, що негативно впливає на опорно-кінематичну функцію нижньої кінцівки й значно погіршує якість життя пацієнта. Зміна природних анатомічних співвідношень в одному суглобі веде до зміни навантаження в суміжних суглобах і провокує розвиток дегенеративних змін. Мета роботи: на моделі ходьби вивчити роботу м’язів нижньої кінцівки за умови контрактури колінного суглоба різного ступеня вираженості. Визначити мінімально необхідну силу м’язів нижньої кінцівки для здійснення нормального кроку. Матеріали та методи. Досліджували порушення роботи м’язів при контрактурах колінного суглоба, які моделювали шляхом обмеження розгинання стегна на 10°, 15° і 20°. Аналіз проводили для м’язів правої нижньої кінцівки, порівнюючи отримані показники з показниками базової моделі (тієї ж кінцівки без обмеження розгинання). Результати. Контрактура колінного суглоба не тільки порушує функцію самого колінного суглоба, але й патологічно впливає на функцію тазостегнового й гомілковостопного суглобів через універсальність роботи більшості двосуглобових м’язів стегна й гомілки. Більше за інші м’язи при контрактурах колінного суглоба страждають розгиначі гомілки. Це пояснюється тим, що для забезпечення правильної ходи необхідне повноцінне розгинання гомілки, і цим м’язам необхідно розвинути силу, здатну подолати контрактуру. Наприклад, при контрактурі 20° для розгинання коліна модель повинна розвинути силу 2250 Н, проте в реальності, за даними Delp (1990), максимально можлива ізометрична сила становить 780 Н, що майже в 3 рази менше. Одним з м’язів, які найбільше впливають на функціональність кульшового суглоба, є m. semitendinosus, у моделях простежується його явне перенапруження. Значно порушується робота m. gracilis і m. sartorius. З перевищенням своїх функціональних можливостей при контрактурі колінного суглоба працює m. biceps femoris — коротка головка. Максимальна напруга, яку здатен розвинути цей м’яз, становить 400 Н, тоді як у моделях з контрактурами колінного суглоба необхідне для нормальної ходьби зусилля досягає 900 Н, що м’яз природно розвинути в реальних умовах не в змозі. Висновки. Контрактура колінного суглоба призводить до зміни біомеханіки всієї нижньої кінцівки. Обмеження рухливості колінного суглоба веде до наростання змін у роботі м’язів, змушуючи їх працювати в умовах постійної напруги чи, навпаки, виключаючи з роботи, що призводить до різкого порушення ходи. Знаючи вплив контрактури колінного суглоба на роботу м’язів нижньої кінцівки, можна прогнозувати перебіг розвитку патологічного процесу, визначити, які групи м’язів страждають найбільше. Враховуючи особливості їх функціонування при тому чи іншому ступені обмеження рухливості колінного суглоба, можна визначити, яка група м’язів потребує корекції до і після оперативного втручання.