bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS KEBUTUHAN RUANG PARKIR (Studi Kasus Pada Area Parkir Institut Teknologi Mitra Gama)
Authors: Prastya Adi
Published: July 2024

Abstrak: Tempat parkir adalah tempat di mana kendaraan berada dalam keadaan tidak bergerak atau diam karena ditinggalkan oleh pengemudinya untuk sementara waktu. Fasilitas parkir sangat penting terutama di lingkungan kampus atau perguruan tinggi, seperti Institut Teknologi Mitra Gama. Mayoritas mahasiswa, dosen, dan staf karyawan menggunakan kendaraan pribadi roda dua (sepeda motor). Analisis terhadap area parkir di Institut Teknologi Mitra Gama, yang memiliki luas sekitar ±500 m2, menunjukkan bahwa area tersebut dapat menampung hingga 235 sepeda motor. Dengan pertimbangan bahwa semakin banyaknya mahasiswa akan meningkatkan kebutuhan akan ruang parkir, penelitian tahap pertama melibatkan pengukuran luas lahan parkir, diikuti oleh survei untuk mencatat jumlah kendaraan yang masuk atau keluar dari area parkir inatitut Teknologi Mitra Gama. Saat ini, dari luas area parkir sekitar ±500 m2, sekitar 393 m2 digunakan untuk memarkir kendaraan dan 107 m2 digunakan sebagai jalur sirkulasi parkir. Hasil penelitian menunjukkan bahwa ruang parkir sudah tidak cukup untuk memenuhi kebutuhan saat ini, dengan volume maksimum kendaraan yang memasuki area parkir mencapai 258 sepeda motor, sementara area parkir Institut Teknologi Mitra Gama dapat menampung hingga 235 kendaraan. Analisis kebutuhan parkir untuk beberapa tahun ke depan menunjukkan bahwa area parkir Institut Teknologi Mitra Gama sudah tidak dapat memenuhi kebutuhan parkir dalam 3 tahun ke depan. Kata kunci: Kebutuhan Parkir, Ruang Parkir, Pola Parkir, parkir
ANALISIS BIAYA OPERASIONAL KENDARAAN ANGKUTAN BUS DI RUTE TERMINAL ENTROP - KOYA
Authors: Rachmattullah Prasetyo Alifathur , Ansusanto J. Dwijoko
Published: July 2024

Transportasi umum di Jayapura sangat penting untuk mobilitas sehari-hari, terutama dengan meningkatnya kebutuhan akibat pertumbuhan penduduk dan pemekaran wilayah. Penelitian ini menganalisisi biaya operasional kendaraan perencanaan angkutan bus di rute Entrop – Koya melalui observasi langsung dan studi pustaka. Hasil menunjukkan bahwa jalur Entrop – Koya belum dilayani angkutan umum memadai, sehingga membuat masyarakat bergantung pada kendaraan pribadi. Analisis biaya operasional menunjukkan tarif bervariasi berdasarkan potensi muatan: Rp 19.000, Rp 18.000, dan Rp 17.000 per orang untuk potensi muatan 70%, 50%, dan 30%. Diperlukan bus dengan kapasitas 30 penumpang untuk melayani rute ini secara optimal. Pengembangan angkutan umum di jalur ini diharapkan meningkatkan kualitas hidup masyarakat, mendukung pertumbuhan ekonomi, dan mengurangi kemacetan serta polusi udara. Penelitian ini menekankan pentingnya perencanaan transportasi yang efisien untuk manfaat masyarakat Jayapura.
Konsep Transportasi Umum Berkelanjutan : Studi Kasus Bus Listrik di Yogyakarta
Authors: Chuadinata Steven , Basuki Imam
Published: July 2024

Transportasi umum yang berkelanjutan menjadi salah satu fokus utama dalam upaya mitigasi perubahan iklim dan peningkatan kualitas udara di perkotaan. Studi ini mengkaji implementasi bus listrik di Yogyakarta sebagai bagian dari upaya menciptakan sistem transportasi umum yang berkelanjutan. Penelitian ini bertujuan untuk mengevaluasi dampak lingkungan, ekonomi, dan sosial dari penggunaan bus listrik, serta mengidentifikasi tantangan dan peluang dalam penerapannya. Perencanaan bus listrik di Yogyakarta dibuat untuk menggantikan bus trans Yogyakarta yang berbahan bakar BBM yang sangat meringankan emisi dengan selisih jumlah 92.046 kg CO₂ dan total estimasi biaya yang diperlukan dalam perencanaan bus lsitrik ini adalah sebesar Rp. 4.148.600.000 dengan biaya pemeliharaan tiap tahun sebesar Rp. 575.325.565,-.Kata kunci: Bus Trans Yogya, Bus Listrik
Scientific and Methodological Principles of Information and Analytical Support for the Digital Transformation of Society: Realities and Future of Education, Pedagogy and Psychology (to the All-Ukrainian Science Festival): Collection of Materials
Authors:   V.O. Sukhomlynskyi State Scientific and Educational Library of Ukraine
Published: July 2024

The collection of materials (abstracts) of the round table «Scientific and Methodological Foundations of Information and Analytical Support for the Digital Transformation of Society: Realities and Future of Education, Pedagogy and Psychology» is dedicated to the All-Ukrainian Festival of Science, held on May 15, 2024 in a mixed format, contains abstracts of the participants' reports and the main organizational documents of the event. The topics of the publications are organized by sections in accordance with the directions indicated in the program. The roundtable is transdisciplinary in nature, i.e., integrative, bringing together scientists, practicing educators, librarians, degree candidates and higher education students from different regions of Ukraine from different educational institutions and research institutions of the NAES of Ukraine: V. Sukhomlynskyi State Scientific and Educational Library of Ukraine, State Higher Educational Institution «University of Educational Management of the National Academy of Pedagogical Sciences of Ukraine»; Ivan Ziayun Institute of Pedagogical and Adult Education of the National Academy of Pedagogical Sciences of Ukraine, etc. The scientific papers highlight the current problems of the development of digital transformation of education, pedagogy and psychology; the main ideas, intermediate and final results of the research of the roundtable participants are revealed, which will facilitate the active exchange of experience and application of the positive results of the presented research in the Ukrainian education system. The collection contains the current results of the planned applied research of the Department of Scientific Information and Analytical Support of Education of the V. Sukhomlynskyi State Scientific and Educational Library of Ukraine, such as: «Information and analytical support of digital transformation of education and pedagogy: domestic and foreign experience» (2023-2025, analytical and synthetic stage), «Information and analytical support of psychological science in the war and post-war periods» (2024-2025, theoretical and analytical stage). The materials of the roundtable may be useful for applicants for scientific education and academic degrees and academic titles, scientists, researchers and teachers of educational institutions of various levels of organization, higher education applicants and all those interested in the problems of digital processes in the scientific and educational space. The authors of abstracts are responsible for violation of the norms of academic integrity and ethical requirements for the presentation of research results, for the relevance and accuracy of the content and information provided in the abstracts on the basis of current legislation
Comparative Principles of The Structure of The Psyche of Homo Sapiens And Artificial General Intelligence - PART 1
Authors: Kruglov Alexander G ,   Central Research Institute of Radiation Diagnostics. Moscow. Russia., Kruglov Andrey A ,   Central Research Institute of Radiation Diagnostics. Moscow. Russia.
Published: July 2024

Properly understanding the structure and dynamics of mental processes is a critical step in determining the significant features of artificial general intelligence operating on the principles of biological systems. The psyche, as a function of the brain, is responsible for creating, preserving, integrating and determining the priority of updating the arsenal of regulatory algorithms that ensure the balancing of physiological and mental homeostasis. Two interdependent information circuits develop simultaneously in the psyche: 1) physiological - control and balancing of homeostasis parameters of the internal environment; 2) psychological - a) creating/maintaining a consistent picture of the external environment and the relationship with it; b) implementation of behavior algorithms to balance homeostasis. The supra-threshold dissociation of homeostasis parameters, both physiological and mental, updates a compensatory need, the encoded information equivalent of which is the goal image, becomes the motive for goal-directed behavior. The psyche uses consciousness for selective interaction with the external environment. Consciousness is the interface of the psyche and the external environment with the selection and control functions of the dynamics of the two-way flow of information in the process of fulfilling a need. In creating motivating frustration structures, the Homo sapiens (HS) creative psyche has modified consciousness into an independent subsystem of the psyche capable of arbitrary, volitional control. The HS psyche is now able to arbitrarily determine the relevance and parameters of goals beyond vital needs, keep their dynamics in focus, and through introspection construct subjectivity in phylo/ontogenesis. Expanding the range of needs beyond the vital arsenal has formed motivational constructs of ideal content, creating the “uncertainty barrier problem.” The general principles of the psyche's action to realize ideal needs under conditions of uncertainty are formulated. The need to overcome "uncertainty barriers", with the a priori impossibility of achieving the ultimate ideal goal of a symbol creates a sequence of homomorphic cycles of behavior that have no prospects of completion
The Mind and the Political
Authors: Teymoori Ali
Published: July 2024

In this commentary I present a brief overview of Maiese and Hanna’s work, The Mind-Body Politic, and highlight their valuable contribution in extending the insights from philosophy of mind to critically evaluate our contemporary social institutions and politics. Then I discuss some of the reservations and open questions about the way Maiese and Hanna lay out their version of a political philosophy of mind. In doing so, I focus on three main shortcomings in Maiese and Hanna’s work. First, I discuss how despite their critical view of Cartesian dualism, their own view of the way society is organized and works is dualistic. I argue that their dualistic view of society results in utopian thinking, and perhaps a more productive and constructive approach to our current predicaments would rather be an immanent critique. Second, I highlight the unclarity and confusion in some of their conceptual frameworks and their account of politics such as the way they use ideology and governmentality. Finally, I criticize their analysis of social institutions, especially the way they see new institutional structures can be formed. The project for a political philosophy of mind that Maiese and Hanna set up is worth pursuing and Maiese and Hanna already provide many hints and directions for its productive and constructive pursuit.
Increasing Soil Bearing Capacity and Shear Modulus with Recycle Concrete Aggregate
Authors: Pertiwi Sheila Ananda Putri , Candra Agata Iwan , Karisma Dwifi Aprillia , Ali Mahardi Kamalika Khusna
Published: July 2024

Soil is an important component in building construction because it supports the structure. Clay soils often pose problems due to their high potential for swelling and shrinkage, which can result in cracking and building settlement. Stabilization of clay soil is an important solution. This research aims to evaluate the effect of recycled aggregate concrete (RCA) from laboratory construction waste on the characteristics of clay soil. The research method involved laboratory experiments, with a mixture of clay and RCA at 5%, 10%, and 15% variations. Testing includes Atterberg Limit, Standard Proctor Test, and Unconfined Compressive Strength (UCS). The results showed that adding RCA increased clay soil's bearing capacity and shear modulus. The peak bearing capacity was achieved by adding 5% RCA, with a Qu value reaching 265.24 kN/m². The shear modulus also increased from 41.63 MPa to 62.442 MPa with the addition of 5% RCA. Thus, the addition of RCA from laboratory construction waste can increase the bearing capacity and shear modulus of clay soil to support construction safety and the principles of sustainable development.
Seismic Performance Evaluation of Reinforced Concrete Building in Palu City
Authors: Nugroho Fajar , Tanjung Jafril , Maidiawati Maidiawati , Kurniawan Ruddy
Published: July 2024

The earthquake accompanied by a tsunami that occurred in Palu City in 2018 resulted in damage, especially reinforced concrete buildings, one of which was the FISIP Dean Building, Tadulako University. This study aims to evaluate the seismic performance of the building using SeismoStruct software. This software is able to predict the behaviour of large displacements of space frames under static or dynamic loading by considering geometric nonlinearity and material inelasticity. Building modelling is made based on Detail Engineering Design drawings. The results of the analysis in the form of a capacity curve show that the building's performance is at the life safety level, which means that structural components are damaged so that the building's strength is reduced. There are two types of building collapse mechanisms that occur, namely yielding in the reinforcement (yield) and collapse in the concrete cover (crush-unconfined). Collapse occurred in the column where it should have occurred in the beam.
Influence of Erosion Potential Analysis Based on Land Use Change in Upper Citarum Watershed
Authors: Parhusip Yemima Gaberiella , Anggraheni Evi
Published: July 2024

Population growth and scientific advances have led to increased human needs that can have an impact on the sustainability of the DAS environment. The Citarum River faces a number of problems, including a decrease in water quality due to pollution, depletion of water quantity especially in the dry season, siltation of rivers due to sedimentation and land degradation upstream of the watershed which is reflected in a large range of water discharge. This study aims to find out the rate of erosion related to land use changes in the Citarum Hulu watershed by using the USLE method combined with image interpretation. The results show that the erosion of rain in 2019 was 1017.64 Kj/ha, then the rate of erosion in land use in 2000 was 136.06 tons/ha/year, land use in 2010 was 217.94 tons/ha/year, and land use in 2023 was 186.72 tons/ha/year. The proposed control measures include structural strategies for erosion-prone areas on Citarum Hulu watershed. Thus, the results of the research can be considered by the local government in efforts to manage the watershed.
Gut Microbiota Metabolite Trimethylamine N-oxide Reduced Pancreatic β Cell Calcium Transients and Function
Authors: Kong Lijuan , Li Pingping
Published: July 2024

Pancreatic β cell dysfunction is an important cause of type 2 diabetes (T2D). Previous studies show trimethylamine N-oxide (TMAO), a gut microbiota-related metabolite, promotes cardiovascular disease and insulin resistance. However, the effect and mechanism of TMAO at pathological concentrations on β cell function remain unknown. The recently published work demonstrates TMAO reduces pancreatic β cell function and glucose homeostasis. Furthermore, TMAO inhibits calcium transients through NLR family pyrin domain containing 3 (NLRP3) inflammasome activation and induced Serca2 loss. Additionally, long-term TMAO exposure promotes β cell endoplasmic reticulum (ER) stress, dedifferentiation and apoptosis. Here, we review the impaired effect of TMAO on β cell function and comment on the implications of this study for understanding the role and mechanism of TMAO in the development of T2D. Further work should focus on screening flavin-containing monooxygenase 3 (FMO3) inhibitors for antidiabetes.
TÜRKİYE’DE KADINLARDA DİSMENORE VE İLİŞKİLİ FAKTÖRLERİN BELİRLENMESİ: KESİTSEL BİR ARAŞTIRMA
Authors: Ceran İrem Gülsüm , Mızrak Şahin Berrak
Published: July 2024

Menstrual bozukluklar %75'e varan oranlarla kadınlarda çok yaygındır ve dismenore menstruasyonla ilişkili en sık bildirilen bozukluktur. Dismenore sıklıkla baş ağrısı, bulantı, kusma ve terleme gibi bulguların eşlik ettiği alt karın bölgesinde ağrılı, kramplı bir his olarak tanımlanır. Primer dismenore ile ilgili yapılan çalışmalarda çeşitli demografik, fiziksel, yaşam tarzı ile ilgili ve psikososyal faktörlerin etkileri araştırılmıştır. Ancak, özellikle Türk toplumunda bu faktörleri bir arada ve kapsamlı şekilde inceleyen çalışmaya ihtiyaç bulunmaktadır. Çalışmamızda, Türk kadınlarında primer dismenore ile ilişkili faktörlerin saptanması amaçlanmıştır. Araştırma, Mayıs 2021-Aralık 2021 tarihlerinde yürütülen kesitsel bir araştırmadır. Çalışmaya, 18 yaşından büyük, okuma-yazma bilen üreme çağındaki 760 kadın dahil edilmiştir. Araştırmada veri toplama aracı olarak Kişisel Bilgi Formu ve Beck Anksiyete Ölçeği kullanılmıştır. Katılımcıların sosyo-demografik ve yaşam tarzı özellikleri karşılaştırıldığında ailede menstrual ağrı öyküsü (p=
THE EFFECT OF PRIMARY AND REPEATED CESAREAN BIRTH ON BREASTFEEDING SUCCESS AND MATERNAL ATTACHMENT LEVEL IN POSTPARTUM: A CROSS-SECTIONAL AND COMPARATIVE STUDY
Authors: Yılmaz Ayşe Nur , Altıparmak Sümeyye , Aksoy Derya Yeşim
Published: July 2024

This research was conducted to determine the effect of primary and repeated cesarean births on breastfeeding success and maternal attachment level in postpartum women. The cross-sectional and comparative study sample consisted of 322 postpartum women who applied to a public hospital in eastern Turkey. Data were collected with the "Personal Information Form", "LATCH Breastfeeding Assessment Tool" and “Maternal Attachment Scale(MAS)". Descriptive statistics, independent group’s t-test, and Pearson correlation analysis were used to analyze the data. The average age of the puerperants with primary and repeat births was determined as 28.14±6.15, and 30.56±4.91, respectively. The mean LATCH and MAS total scores of postpartum women who had primary cesarean delivery were lower than those of postpartum women who had repeated cesarean delivery, and the difference between them was statistically significant(p=0.000). It was found that there was a weak, positive relationship between the MAS and LATCH score averages of women who had primary and repeated cesarean deliveries, and as breastfeeding success increased, the level of attachment also increased. It was concluded that breastfeeding success and attachment levels were lower in primary cesarean births compared to repeated cesarean births, and as the breastfeeding success achieved in both groups increased, the level of attachment increased.
INVESTIGATION OF THE RELATIONSHIP BETWEEN WORKING POSTURES OF PHYSIOTHERAPISTS WORKING IN SPECIAL EDUCATION AND REHABILITATION CENTERS AND HOSPITALS WITH PAIN, BODY AWARENESS LEVEL, CHRONIC FATIGUE AND DEPRESSION
Authors: Demirtaş Karaoba Dilan , Talu Burcu
Published: July 2024

This study aims to examine the relationship between physiotherapists' working posture and pain, body awareness level, chronic fatigue, and depression levels and to determine whether these parameters depend on the institution where they work. 93 randomly selected physiotherapists between the ages of 24-52 were divided into two groups according to their institutions: Rehabilitation centers/hospitals. Working posture was evaluated with the Ovako Working Posture Analysing System (OWAS), pain was evaluated with the Extended Nordic Musculoskeletal Questionnaire (NMQ-E) and Visual Analogue Scale (VAS), body awareness level was evaluated with the Body Awareness Questionnaire (BAQ), chronic fatigue was evaluated with the Chronic Fatigue Syndrome/Self Assessment Form (CFS), depression level was evaluated with the Beck Depression Inventory (BDI). A relationship was found between OWAS-leg posture and NMQ-E-ankle pain (r=-0.238), between OWAS-back posture-arm posture-action class and VAS (r1=0.25; r2=-0.27; r3=0.23), and between OWAS-back posture-action class and BDI (r1=0.25; r2=0.26) (p
تأثير طريقة تقديم القصة لنتيجة مادة المحادثة لطلاب الصف الثامن المدرسة الثانوية السلفية الشافعية تبوئرنج جومبانج
Authors: Zuhro Fatimah , Qodir Abdul
Published: July 2024

Learning a foreign language is not easy and requires a long process. Because learning a foreign language is difficult, it is necessary to apply various methods in learning so that learning Arabic can run effectively and conducively. One of the interesting ways among several methods used in language learning is Taqdimul qishah or in English it is called Telling Story. Taqdimul qishah is telling stories using Arabic. The taqdimul qishoh method is a way of conveying or presenting learning material orally in the form of stories or fairy tales from teacher to student or from student to student. This study used a quantitative method (ex post facto) by using a questionnaire for class VIII students with forty-seven students. The distribution of this questionnaire aims to determine whether there is an effect of using this method or not. In determining the learning outcomes of conversation subjects, researchers used the results of oral tests with students arranged by grades. From the results of these scores it was concluded that the scores for the Arabic language subject (conversation subject) were obtained from 47 grade VIII students of MTs Salafiyah Syafi'iyyah Tebuireng Jombang, all of whom met the KKM, with an average score of 88. After distributing the questionnaire and student scores, followed by a partial test of the story presentation method variable (X) with a significance value of 0.004 <0.05, Ho was rejected and Ha was accepted, meaning that the story presentation method variable had a significant effect on the material learning outcomes variable.
Personality and Conflict Analysis of Katniss in the Hunger Games Novel
Authors: Mahfudhotin Qomariyah  , Ria Kamilah Agustina
Published: July 2024

The purpose of this study is to analyze personality psychology experienced by the main character and also to find out how the conflict that occurs to the main character. The research method used in this study was library research. The data source was the novel “The Hunger Games” by Suzzane Chollins. The data collection techniques used was observation, documentation and note taking. The data analysis used was reading, summarizing, extracting and analyzing. The result of the study can be formulated that there are several conflicts that occur in the main character. The researcher also analyzed the personality of Katniss was described as a brave, loving and unyielding child.
IMPLEMENTATION OF THE TOTAL PHYSICAL RESPONSE (TPR) LEARNING METHOD IN LEARNING ENGLISH IN PRIMARY SCHOOL
Authors: Daristin Pipit Ertika , Rokhim Arif Nur , Maghfiroh
Published: July 2024

This research aims to describe and explain the implementation of the Total Physical Response (TPR) learning method to develop the speaking skills of third grade elementary school students. This research is a qualitative descriptive study. The subjects of this research were students aged 8-9 years. The techniques used in this research are observation, interviews and documentation. The results of this research describe the implementation of the Total Physical Response (TPR) method in English learning for third grade elementary school students. This research shows the role of the teacher along with the stages of the method in English language learning activities with Total Physical Response, and shows that the total physical response (TPR) method is an appropriate method to use in learning for elementary school students, so it is hoped that its implementation will be developed in different age groups and other aspects of children's development .
Courtyard Housing around the World: A Cross-Cultural Analysis and Contemporary Relevance
Authors: Zhang Donia
Published: July 2024

The courtyard house is one of the oldest dwelling types, spanning at least 5,000 years and occurring in distinctive forms in many parts of the world across climates and cultures. This article takes a panoramic view and makes a cross-cultural analysis of the courtyard houses in six cultures: Chinese, Indian, Islamic, Greco-Roman, Spanish, and Hispanic-American, by addressing four areas of concern: cosmic axis and architectural symbolism, favorable orientation of buildings, socio-spatial organization, and cultural activities in the courtyard houses. It then looks at contemporary new courtyard housing around the world. The paper concludes that the courtyard form is a common heritage of humanity that has a past as well as a future. Moreover, the courtyard form has been built all over the world, and the shared meaning of the courtyard house is an earthly paradise, from which one may construe that the meaning of the world is a courtyard garden.
Prosociality and Mental Health Indicators in Portuguese Adolescents – Validation of Prosocialness Scale
Authors: Gouveia Ana Catarina Gouveia , Cunha Marina , Galhardo Ana , Carreiras Diogo
Published: July 2024

Our research aimed to validate the Prosocialness Scale (PS) among Portuguese adolescents. We sought to examine its factorial structure, model invariance across biological sex, reliability, and association with sociodemographic and other relevant variables. Our sample included 454 adolescents aged 13 to 17 who completed self-report measures assessing psychological flexibility, negative emotions, mental health, and prosocial behavior. The PS demonstrated a bifactorial structure comprising a latent factor (prosociality) and two specific factors (actions and feelings). It exhibited satisfactory internal consistency and test-retest reliability.
Moreover, it showed positive correlations with psychological flexibility and mental health while negatively correlating with negative affective states. The PS emerged as a valid and reliable instrument for gauging prosocial behaviors, holding promise for application as a screening tool in educational and clinical settings. It may also facilitate the evaluation of interventions aimed at fostering prosocial conduct.
Influencia del abuso sexual infantil en la somatización, la conducta sociosexual y las relaciones sexuales en la edad adulta
Authors: De Miguel Adelia , Quijada María , García Roberto
Published: July 2024

En este estudio se ha medido la somatización, la conducta sociosexual y las relaciones sexuales en la vida adulta de víctimas de abuso sexual infantil, analizando cómo aquellas áreas se relacionan entre sí en la edad adulta. Participaron 319 personas, entre las que había 267 mujeres y 52 hombres, y entre ellos, 59 víctimas y 258 no víctimas de abuso sexual infantil (rango de edad 18-72 años). Todos los participantes cumplimentaron en línea, voluntariamente, los autoinformes SCL-90-R, SOI-R, FSFI así como un cuestionario diseñado para medir las experiencias de abuso. Las comparaciones bivariadas en función de haber sino o no víctima de abuso sexual no encontraron ningún resultado significativo en las tres áreas psicológicas evaluadas. En cambio, el análisis específico entre las víctimas mostró que sí había diferencias significativas en el área de la sociosexualidad. Estos resultados deben analizarse con mucha precaución, no pudiendo generalizar. Es preciso tener en cuenta el tiempo transcurrido desde que se sufrió el abuso y tipo de abuso vivido, así como la coexistencia de otros sucesos estresantes, la vivenciación del menor y la asistencia o no a terapia psicológica.
The Long-term Correlation between HbA1c Levels and Memory Impairments and Depressive State in Diabetes Mellitus
Authors: Sarica Darol Elif , Eker Salih
Published: July 2024

Aim: Diabetes mellitus can lead to cognitive and psychological disorders, which can negatively affect patients' glycemic control. Monitoring a patient's HbA1c level is important to evaluate the success of diabetic treatment. We aimed to evaluate whether the mental and depressive states of the patients were associated with HbA1c levels of diabetes mellitus in the long term.

Methods: Data including demographic features were collected from the 138 patients with diabetes. Mini-mental state examination test and Beck Depression Inventory were applied. The last HbA1c and the mean HbA1c values were derived; and used to evaluate whether the demographic features, Mini-mental State Examination Test, and Beck Depression Inventory score were associated with the mid-term and the long-term glycemic stability or not, respectively.

Results: There was not any significant correlation between the Mini-mental State Examination Test scores and the last or the mean HbA1c levels. Beck Depression Inventory scores were positively correlated with the last and the mean-HbA1c levels (p=0.001 and p<0.001, respectively). Female patients with glycemic variability had higher depression scores (p=0.001). Moreover, there was a statistically insignificant positive correlation between both mean and latest HbA1c levels and depression scores (p<0.05).

Conclusion: Our results revealed that patients with glycemic variability, both in the mid and long-term, have more severe depressive symptoms than others, in particular females. Considering these results, we suggested that blood sugar regulation should be ensured first in diabetes mellitus patients presenting with memory impairments and that female patients with low education levels should be questioned more carefully in terms of depression.

Keywords: diabetes mellitus, Hb A1c, cognitive impairments, depressive symptoms, gender
Sick building syndrome: do outdoor pollutants and pollen affect it?
Authors: González-Díaz Sandra Nora , Hernández-Salcido Grecia Jaqueline , de Lira-Quezada Cindy Elizabeth , Cantú-Hernández Jorge Alberto , Macouzet-Sánchez Carlos , Macias-Weinmann Alejandra , Acuña-Ortega Natalhie
Published: July 2024

Introduction

Sick building syndrome (SBS) refers to non-specific complaints, including upper-respiratory irritative symptoms, headaches, fatigue, and rash, which are usually associated with a particular building by their temporal pattern of occurrence and clustering among inhabitants or colleagues. The aim of the study was to determine the association between the clinical manifestations of sick building syndrome with outdoor pollutants and airborne pollen.

Methods

It was a descriptive and prospective observational study conducted from November 2021 to April 2022. It included subjects over 18 years old who completed an online survey on sick building syndrome (general symptoms, nasal, ocular, oropharyngeal, and skin symptoms) presented at home, housing information and personal history. The APS-330 from Pollen Sense ® was used to obtain data on pollen in the air and the local pollution monitoring system (SIMA) to obtain information regarding pollutants. For statistical analysis, SPSS version 16 was used.

Results

A total of 402 surveys were included; 91% of the subjects reported having at least 1 symptom. Females presented more general symptoms (fatigue and headache) than males. Subjects with a personal history of atopy showed a higher prevalence of practically all symptoms. Airborne pollen exposure was positively associated with mucosal symptoms in eyes and nose. Outdoor fungi spore exposure was positively associated with oculo-nasal and cutaneous symptoms in the scalp.

Conclusion

This study found significant associations with female gender and a history of atopy, which suggests a higher risk for these subjects. Despite the limitations of the study, we can conclude that there is an association between the clinical manifestations of sick building syndrome with indoor and outdoor pollution.
Targeting cellular mitophagy as a strategy for human cancers
Authors: Dong Yuming , Zhang Xue
Published: July 2024

Mitophagy is the cellular process to selectively eliminate dysfunctional mitochondria, governing the number and quality of mitochondria. Dysregulation of mitophagy may lead to the accumulation of damaged mitochondria, which plays an important role in the initiation and development of tumors. Mitophagy includes ubiquitin-dependent pathways mediated by PINK1/Parkin and non-ubiquitin dependent pathways mediated by mitochondrial autophagic receptors including NIX, BNIP3, and FUNDC1. Cellular mitophagy widely participates in multiple cellular process including metabolic reprogramming, anti-tumor immunity, ferroptosis, as well as the interaction between tumor cells and tumor-microenvironment. And cellular mitophagy also regulates tumor proliferation and metastasis, stemness, chemoresistance, resistance to targeted therapy and radiotherapy. In this review, we summarized the underlying molecular mechanisms of mitophagy and discussed the complex role of mitophagy in diverse contexts of tumors, indicating it as a promising target in the mitophagy-related anti-tumor therapy.
Polymeric nanomaterials encapsulating fluorescent polyindole-nido- carborane: design, synthesis and biological evaluation
Authors: Cao Jia , Jin Tao , Shao Shihe , Mao Boneng , Feng Jin
Published: July 2024

The water-soluble nido-carborane was prepared by alkali treatment of o-carborane. A polymer PInd containing a polyindole structure was synthesized and employed to label the modified o-carborane. Subsequently, four polymeric nanomaterials were synthesized with the objective of encapsulating them in order to enhance its bioavailability. The experimental results showed that the fluorescent complex encapsulated by the pH-sensitive polymer A had the best UV absorption and fluorescence intensity, and thus A-PInd-C was chosen for subsequent experiments. The Transmission electron microscopy images revealed that the compounds exhibited a rounded internal morphology, with the layers exhibiting a tightly stacked arrangement. The AFM imaging revealed that the surface of the sample exhibited a relatively uniform and smooth appearance. In vitro release experiments conducted under acidic conditions demonstrated that A-PInd-C was released in a predominantly linear manner, with a maximum release rate of 80% observed within 48 h. Cellular imaging experiments showed that the compound could enter HeLa and HCT-116 cells and was mainly distributed around the nucleus, especially in the acidic environment. The results of the cell proliferation toxicity experiments demonstrated that A-PInd-C exhibited inhibitory effects on HeLa, PC-3 and L02 cells. Among these, the inhibitory effect on PC-3 cells was the most pronounced, reaching up to 70%. In conclusion, this paper solves the problem of poor bioavailability of carborane by improving the boron containing compounds and also makes the system have potential for Boron neutron capture therapy.
Microbiota, natural products, and human health: exploring interactions for therapeutic insights
Authors: Qadri Hafsa , Shah Abdul Haseeb , Almilaibary Abdullah , Mir Manzoor Ahmad
Published: July 2024

The symbiotic relationship between the human digestive system and its intricate microbiota is a captivating field of study that continues to unfold. Comprising predominantly anaerobic bacteria, this complex microbial ecosystem, teeming with trillions of organisms, plays a crucial role in various physiological processes. Beyond its primary function in breaking down indigestible dietary components, this microbial community significantly influences immune system modulation, central nervous system function, and disease prevention. Despite the strides made in microbiome research, the precise mechanisms underlying how bacterial effector functions impact mammalian and microbiome physiology remain elusive. Unlike the traditional DNA-RNA-protein paradigm, bacteria often communicate through small molecules, underscoring the imperative to identify compounds produced by human-associated bacteria. The gut microbiome emerges as a linchpin in the transformation of natural products, generating metabolites with distinct physiological functions. Unraveling these microbial transformations holds the key to understanding the pharmacological activities and metabolic mechanisms of natural products. Notably, the potential to leverage gut microorganisms for large-scale synthesis of bioactive compounds remains an underexplored frontier with promising implications. This review serves as a synthesis of current knowledge, shedding light on the dynamic interplay between natural products, bacteria, and human health. In doing so, it contributes to our evolving comprehension of microbiome dynamics, opening avenues for innovative applications in medicine and therapeutics. As we delve deeper into this intricate web of interactions, the prospect of harnessing the power of the gut microbiome for transformative medical interventions becomes increasingly tantalizing.
Beyond antibiotics: CRISPR/Cas9 triumph over biofilm-associated antibiotic resistance infections
Authors: Zuberi Azna , Ahmad Nayeem , Ahmad Hafiz , Saeed Mohd , Ahmad Irfan
Published: July 2024

A complex structure known as a biofilm is formed when a variety of bacterial colonies or a single type of cell in a group sticks to a surface. The extracellular polymeric compounds that encase these cells, often consisting of proteins, eDNA, and polysaccharides, exhibit strong antibiotic resistance. Concerns about biofilm in the pharmaceutical industry, public health, and medical fields have sparked a lot of interest, as antibiotic resistance is a unique capacity exhibited by these biofilm-producing bacteria, which increases morbidity and death. Biofilm formation is a complicated process that is controlled by several variables. Insights into the processes to target for the therapy have been gained from multiple attempts to dissect the biofilm formation process. Targeting pathogens within a biofilm is profitable because the bacterial pathogens become considerably more resistant to drugs in the biofilm state. Although biofilm-mediated infections can be lessened using the currently available medications, there has been a lot of focus on the development of new approaches, such as bioinformatics tools, for both treating and preventing the production of biofilms. Technologies such as transcriptomics, metabolomics, nanotherapeutics and proteomics are also used to develop novel anti-biofilm agents. These techniques help to identify small compounds that can be used to inhibit important biofilm regulators. The field of appropriate control strategies to avoid biofilm formation is expanding quickly because of this spurred study. As a result, the current article addresses our current knowledge of how biofilms form, the mechanisms by which bacteria in biofilms resist antibiotics, and cutting-edge treatment approaches for infections caused by biofilms. Furthermore, we have showcased current ongoing research utilizing the CRISPR/Cas9 gene editing system to combat bacterial biofilm infections, particularly those brought on by lethal drug-resistant pathogens, concluded the article with a novel hypothesis and aspirations, and acknowledged certain limitations.
Portion coherence: enhancing the relevance of introductory courses in teacher education
Authors: Biberman-Shalev Liat , Pinku Guy , Hemi Alla , Nativ Yael , Paz Omri , Enav Yarden
Published: July 2024

Studies investigating coherence in teacher preparation often attempt to achieve comprehensive coherence across all components of training to optimize the educational process. Nevertheless, the pursuit of intense coherence presents notable challenges. To address these challenges, we propose the concept of portion coherence, exemplified by the Trio model, which guides pre-service teachers in integrating theories into their practices. Through a mixed-method study, we compared pre-service teachers’ perceptions of the importance and relevance of introductory courses at the semester’s outset and conclusion. While both groups reported a reduction in perceived importance, the intervention group noted a significantly smaller decline in perceived relevance compared to the control group. This suggests that models of portion coherence may enhance the perceived relevance of educational courses, while the perceived relevance of introductory education courses may serve as an indicator of cross-course coherence.
Factors associated with psychological insulin resistance among patients with type 2 diabetes in China
Authors: Zhang Shilong , Zhang Xindan , Wang Haipeng , Fan Wenyu , Ma Xingli , Song Suhang , Zhang Beibei
Published: July 2024

Objective

The aim of this study was to understand the psychological insulin resistance status among Chinese patients with type 2 diabetes and investigate its associated factors in these patients.

Methods

A multi-stage stratified random sampling was performed to randomly select patients with type 2 diabetes from the eastern, central, and western regions in Shandong Province, China, and 660 valid questionnaires were collected. Psychological insulin resistance was assessed by the scale of My Opinion on Insulin (MOI). Factors associated with psychological insulin resistance were examined in a binary logistic model.

Results

Four-fifths of the patients with type 2 diabetes (82.1%) had psychological insulin resistance. Being female (OR = 1.770, 95% CI: 1.063–2.950, p < 0.05), having a monthly income of greater than 4,000 Renminbi (approximately $1,540) (OR = 0.444, 95% CI: 0.216–0.915, p < 0.05), living with type 2 diabetes for 11 years or more (OR = 0.387, 95% CI: 0.238–0.630, p < 0.05), self-rated poor health (OR = 1.706, 95% CI: 1.092–2.664, p < 0.05), and moderate discrimination against type 2 diabetes (OR = 1.924, 95% CI: 1.166–3.175, p < 0.05) were associated with psychological insulin resistance.

Conclusions

The prevalence of psychological insulin resistance among Chinese patients with type 2 diabetes is relatively high. Approaches are needed to address the issue of psychological insulin resistance of type 2 diabetes.
Identifying novel potential drug targets for endometriosis via plasma proteome screening
Authors: Tao Tian , Mo Xiaoyu , Zhao Liangbin
Published: July 2024

Background

Endometriosis (EM) is a chronic painful condition that predominantly affects women of reproductive age. Currently, surgery or medication can only provide limited symptom relief. This study used a comprehensive genetic analytical approach to explore potential drug targets for EM in the plasma proteome.

Methods

In this study, 2,923 plasma proteins were selected as exposure and EM as outcome for two-sample Mendelian randomization (MR) analyses. The plasma proteomic data were derived from the UK Biobank Pharmaceutical Proteomics Project (UKB-PPP), while the EM dataset from the FinnGen consortium R10 release data. Several sensitivity analyses were performed, including summary-data-based MR (SMR) analyses, heterogeneity in dependent instruments (HEIDI) test, reverse MR analyses, steiger detection test, and bayesian co-localization analyses. Furthermore, proteome-wide association study (PWAS) and single-cell transcriptomic analyses were also conducted to validate the findings.

Results

Six significant (p < 3.06 × 10-5) plasma protein-EM pairs were identified by MR analyses. These included EPHB4 (OR = 1.40, 95% CI: 1.20 - 1.63), FSHB (OR = 3.91, 95% CI: 3.13 - 4.87), RSPO3 (OR = 1.60, 95% CI: 1.38 - 1.86), SEZ6L2 (OR = 1.44, 95% CI: 1.23 - 1.68) and WASHC3 (OR = 2.00, 95% CI: 1.54 - 2.59) were identified as risk factors, whereas KDR (OR = 0.80, 95% CI: 0.75 - 0.90) was found to be a protective factor. All six plasma proteins passed the SMR test (P < 8.33 × 10-3), but only four plasma proteins passed the HEIDI heterogeneity test (PHEIDI > 0.05), namely FSHB, RSPO3, SEZ6L2 and EPHB4. These four proteins showed strong evidence of co-localization (PPH4 > 0.7). In particular, RSPO3 and EPHB4 were replicated in the validated PWAS. Single-cell analyses revealed high expression of SEZ6L2 and EPHB4 in stromal and epithelial cells within EM lesions, while RSPO3 exhibited elevated expression in stromal cells and fibroblasts.

Conclusion

Our study identified FSHB, RSPO3, SEZ6L2, and EPHB4 as potential drug targets for EM and highlighted the critical role of stromal and epithelial cells in disease development. These findings provide new insights into the diagnosis and treatment of EM.
Day-ahead and hour-ahead optimal scheduling for battery storage of renewable energy power stations participating in primary frequency regulation
Authors: Hu Huaizhong , Ma Yanzhao , Zhang Xiaoke , Han Chongshang , Hao Yiran
Published: July 2024

Due to the fast response characteristics of battery storage, many renewable energy power stations equip battery storage to participate in auxiliary frequency regulation services of the grid, especially primary frequency regulation (PFR). In order to make full use of the battery capacity and improve the overall revenue of the renewable energy station, a two-level optimal scheduling strategy for battery storage is proposed to provide primary frequency regulation and simultaneously arbitrage, according to the peak-valley electricity price. The energy storage output is composed of the droop-based primary frequency regulation output and the economic output, according to the electricity price. First, day-ahead optimization defines the economic output profile and an appropriate droop coefficient, considering regulation needs, with the goal of maximizing the overall return. The scheduling result is then adjusted for hour-ahead optimization based on the updated regulation information to ensure more durable and reliable performance. Simulation results show that the proposed scheduling strategy can fully utilize the battery capacity, realize peak-valley arbitrage while assuming the obligation of primary frequency regulation of the renewable energy power station, and then improve the overall income of the power station.
Disentangling the simultaneous effects of habitat degradation and introduced species on naturally depauperate riverine fish communities
Authors: Meijer Christopher G. , Hickford Michael J. H. , Gray Duncan P. , Schiel David R.
Published: July 2024

Introduction

Global change is a multi-faceted issue putting many species at risk. The broad range of potentially interacting environmental stressors is problematic for effective and efficient conservation and management. In freshwater systems, habitat degradation and introduced species have been repeatedly recognized for their extensive impacts on native ecosystems. However, the simultaneous impacts of these environmental stressors on naturally depauperate and inherently vulnerable communities are poorly understood.

Methods

In southern New Zealand, the fish communities in 14 tributaries of three lowland lakes were surveyed to quantify the within- and between-community changes along gradients of habitat complexity and abundance of introduced species, specifically brown trout (Salmo trutta Linnaeus) and redfin perch (Perca fluviatilis Linnaeus).

Results

Stable isotope analyses identified that trophic diversity increased with habitat complexity and an abundance of native eels (Anguilla spp.) but was unaffected by introduced species. Within each community, only perch exhibited distinct dietary shifts along all environmental gradients, whereas trout and the native fish had consistent, generalist diets. When supported with length–weight regressions, these impacts became increasingly size-dependent. For example, among the native fish, only the larger eels were unaffected by habitat and achieved greater body conditions with increased numbers of eels and perch; however, more trout were detrimental to eel body condition. In contrast, the smaller bodied natives, including elvers, all had improved body conditions from increased habitat complexity and reduced numbers of trout and perch. For the introduced species, perch weights were consistent regardless of the local environment due to their variable diet, but larger trout generally increased in weight with reduced habitat complexity and greater numbers of introduced fish, although high eel densities were detrimental.

Discussion

Overall, our results highlight how the responses to environmental stressors, even in depauperate communities, are complicated and generally species-specific. Nonetheless, habitat degradation had the most wide-ranging negative impacts on native fish, with perch numbers only affecting the smaller bodied natives and trout only affecting one native species. We conclude that focusing on habitat restoration in conservation strategies will provide the most efficient and effective use of resources, although the realized benefits for native species will be limited if introduced species are overly abundant.