bluuebunny/crossref_metadata_2025 huggingface dataset:
Your Heart Function Has Normalized—What Next After TRED-HF?
Authors: Kasiakogias Alexandros , Ragavan Aaraby , Halliday Brian P.
Published: November 2023

Purpose of Review

With the widespread implementation of contemporary disease-modifying heart failure therapy, the rates of normalization of ejection fraction are continuously increasing. The TRED-HF trial confirmed that heart failure remission rather than complete recovery is typical in patients with dilated cardiomyopathy who respond to therapy. The present review outlines key points related to the management and knowledge gaps of this growing patient group, focusing on patients with non-ischaemic dilated cardiomyopathy.

Recent Findings

There is substantial heterogeneity among patients with normalized ejection fraction. The specific etiology is likely to affect the outcome, although a multiple-hit phenotype is frequent and may not be identified without comprehensive characterization. A monogenic or polygenic genetic susceptibility is common. Ongoing pathophysiological processes may be unraveled with advanced cardiac imaging, biomarkers, multi-omics, and machine learning technologies. There are limited studies that have investigated the withdrawal of specific heart failure therapies in these patients. Diuretics may be safely withdrawn if there is no evidence of congestion, while continued therapy with at least some disease-modifying therapy is likely to be required to reduce myocardial workload and sustain remission for the vast majority.

Understanding the underlying disease mechanisms of patients with normalized ejection fraction is crucial in identifying markers of myocardial relapse and guiding individualized therapy in the future. Ongoing clinical trials should inform personalized approaches to therapy.
High Levels of NfL, GFAP, TAU, and UCH-L1 as Potential Predictor Biomarkers of Severity and Lethality in Acute COVID-19
Authors: Salvio Andreza Lemos , Fernandes Renan Amphilophio , Ferreira Helena França Alcaraz , Duarte Larissa Araujo , Gutman Elisa Gouvea , Raposo-Vedovi Jessica Vasques , Filho Carlos Henrique Ferreira Ramos , da Costa Nunes Pimentel Coelho Wagner Luis , Passos Giselle Fazzioni , Andraus Maria Emília Cosenza , da Costa Gonçalves João Paulo , Cavalcanti Marta Guimarães , Amaro Marisa Pimentel , Kader Rafael , de Andrade Medronho Roberto , Figueiredo Cláudia Pinto , Amado-Leon Luciane Almeida , Alves-Leon Soniza Vieira
Published: November 2023

Few studies showed that neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), total tubulin-associated unit (TAU), and ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) may be related to neurological manifestations and severity during and after SARS-CoV-2 infection. The objective of this work was to investigate the relationship among nervous system biomarkers (NfL, TAU, GFAP, and UCH-L1), biochemical parameters, and viral loads with heterogeneous outcomes in a cohort of severe COVID-19 patients admitted in Intensive Care Unit (ICU) of a university hospital. For that, 108 subjects were recruited within the first 5 days at ICU. In parallel, 16 mild COVID-19 patients were enrolled. Severe COVID-19 group was divided between “deceased” and “survivor.” All subjects were positive for SARS-CoV-2 detection. NfL, total TAU, GFAP, and UCH-L1 quantification in plasma was performed using SIMOA SR-X platform. Of 108 severe patients, 36 (33.33%) presented neurological manifestation and 41 (37.96%) died. All four biomarkers — GFAP, NfL, TAU, and UCH-L1 — were significantly higher among deceased patients in comparison to survivors (p < 0.05). Analyzing biochemical biomarkers, higher Peak Serum Ferritin, D-Dimer Peak, Gamma-glutamyltransferase, and C-Reactive Protein levels were related to death (p < 0.0001). In multivariate analysis, GFAP, NfL, TAU, UCH-L1, and Peak Serum Ferritin levels were correlated to death. Regarding SARS-CoV-2 viral load, no statistical difference was observed for any group. Thus, Ferritin, NFL, GFAP, TAU, and UCH-L1 are early biomarkers of severity and lethality of SARS-COV-2 infection and may be important tools for therapeutic decision-making in the acute phase of disease.
Mapping the immunological battlefield in gastric cancer: prognostic implications of an immune gene expression signature
Authors: Meng Xianhong , Wang Daxiu , Sun Xueying , Yuan Jiangfeng , Han Jiwu
Published: November 2023

Background

Gastric cancer (GC) is a heterogeneous malignancy with variable clinical outcomes. The immune system has been implicated in GC development and progression, highlighting the importance of immune-related gene expression patterns and their prognostic significance.

Objective

This study aimed to identify differentially expressed immune-related genes (DEIRGs) and establish a prognostic index for GC patients using comprehensive bioinformatic analyses.

Methods

We integrated RNA sequencing data from multiple databases and identified DEIRGs by overlapping differentially expressed genes with immune-related genes. Functional enrichment analysis was performed to uncover the biological processes and signaling pathways associated with DEIRGs. We conducted a Weighted Gene Co-expression Network Analysis (WGCNA) to identify key gene modules related to with GC. Cox regression analysis was conducted to determine independent prognostic DEIRGs for overall survival prediction. Based on these findings, we developed an immune-related gene prognostic index (IRGPI) based on these findings. The prognostic value of the IRGPI was validated using survival analysis and an independent validation cohort. Functional enrichment analysis, gene mutation analysis, and immune cell profiling were performed to gain insights into the biological functions and immune characteristics associated with the IRGPI-based subgroups.

Results

We identified 493 DEIRGs significantly enriched in immune-related biological processes and signaling pathways associated with GC. WGCNA analysis revealed a significant module (turquoise module) associated with GC, revealing potential therapeutic targets. Cox regression analysis identified RNASE2, CGB5, CTLA4, and DUSP1 as independent prognostic DEIRGs. The IRGPI, incorporating the expression levels of these genes, demonstrated significant prognostic value in predicting overall survival. The IRGPI-based subgroups exhibited distinct biological functions, genetic alterations, and immune cell compositions.

Conclusion

Our study identified DEIRGs and established a prognostic index (IRGPI) for GC patients. The IRGPI exhibited promising prognostic potential and provided insights into GC tumor biology and immune characteristics. These findings have implications for guiding therapeutic strategies.
Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease
Authors: Mogna-Peláez Paola , Romo-Hualde Ana , Riezu-Boj José I. , Milagro Fermin I. , Muñoz-Prieto David , Herrero José I. , Elorz Mariana , Benito-Boillos Alberto , Monreal J. Ignacio , Tur Josep A. , Martínez Alfredo , Abete Itziar , Zulet M. Angeles
Published: November 2023

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease in the world. New non-invasive diagnostic tools are needed to promptly treat this disease and avoid its complications. This study aimed to find key metabolites and related variables that could be used to predict and diagnose NAFLD. Ninety-eight subjects with NAFLD and 45 controls from the Fatty Liver in Obesity (FLiO) Study (NCT03183193) were analyzed. NAFLD was diagnosed and graded by ultrasound and classified into two groups: 0 (controls) and ≥ 1 (NAFLD). Hepatic status was additionally assessed through magnetic resonance imaging (MRI), elastography, and determination of transaminases. Anthropometry, body composition (DXA), biochemical parameters, and lifestyle factors were evaluated as well. Non-targeted metabolomics of serum was performed with high-performance liquid chromatography coupled to time-of-flight mass spectrometry (HPLC-TOF-MS). Isoliquiritigenin (ISO) had the strongest association with NAFLD out of the determinant metabolites. Individuals with higher concentrations of ISO had healthier metabolic and hepatic status and were less likely to have NAFLD (OR 0.13). Receiver operating characteristic (ROC) curves demonstrated the predictive power of ISO in panel combination with other NAFLD and IR-related variables, such as visceral adipose tissue (VAT) (AUROC 0.972), adiponectin (AUROC 0.917), plasmatic glucose (AUROC 0.817), and CK18-M30 (AUROC 0.810). Individuals with lower levels of ISO have from 71 to 82% more risk of presenting NAFLD compared to individuals with higher levels. Metabolites such as ISO, in combination with visceral adipose tissue, IR, and related markers, constitute a potential non-invasive tool to predict and diagnose NAFLD.
Synthesis of a nanocomposite with holocellulose extracted from barley straw and montmorillonite, and optimization of the removal of methylene blue dye using the synthesized adsorbent
Authors: Farzi Ali , Soltani Milad , Ostadrahimi Alireza , Soleimanzadeh Hamid , Namjoufar Mehran
Published: November 2023

In this study, holocellulose was extracted from milled barley straw with different mesh sizes using Laccase enzyme. After extraction, a dual composite was made using montmorillonite clay to remove methylene blue dye from synthetic effluent. Results of different analysis methods including scanning electron microscope, Fourier transform infrared spectroscopy, and BET revealed that prepared nanocomposite presented desired specifications, and for smaller mesh sizes, derived holocellulose had higher quality due to high specific surface area. Response surface methodology was employed to reduce the number of experiments for methylene blue adsorption experiments and to achieve an empirical model for prediction of adsorption efficiency at different operating conditions. The effect of different factors including solution temperature, pH, initial dye concentration, and mesh size of milled barley straw on dye adsorption performance by prepared composite was examined. Maximum removal efficiency was obtained about 95% at temperature of 32 °C, pH of 8, initial dye concentration of 4 mg L−1, and mesh size of 70. Also, isotherm studies were performed on experimental data using Langmuir, Freundlich, Temkin, and Dubinin–Radushkevich isotherm models and results revealed that the adsorption process follows Langmuir model with maximum predicted adsorption capacity of 159 mg g−1, which implies monolayer adsorption. Moreover, thermodynamic study revealed that adsorption of methylene blue is endothermic and spontaneous while enthalpy and Gibbs free energy of adsorption are positive and negative, respectively. Finally, adsorption kinetic study determined that the pseudo-second-order kinetics model with correlation coefficient of about 1 best fitted the experimental results which is the characteristic of chemisorption process.
Pathways and determinants of changing nutrient management in lowland rice-based systems of Southeast Asia
Authors: Becker Mathias , Clavero Richelyn , Maung Zar Ni , Khin Ohnmar Min , Kong Sichantha , Men Punlork , Regalado Manuel José C. , Ro Sophoanrith , Win Kyaw Kyaw , Pariyar Shyam
Published: November 2023

Production increases in lowland rice-based systems of Southeast Asia will not be possible without the addition of nutrients. Recent productivity gains were largely based on increasing the use efficiency of the applied nutrients through integrated and site-specific approaches. The adoption of such strategies has evolved differentially in the various country. We need to understand such recent trends, their driving forces, and their effectiveness to harness or leverage them for regional food security and sustainable development. To gain this understanding, we analyzed changes in fertility-related agronomic practices in six representative rice-based production systems of Southeast Asia (three favorable and three marginal sites). We implemented a diachronic survey (comparing the years 2000 and 2018) combined with field sampling and measurements in 1024 rice-producing households and, where applicable, in both dry and wet seasons (3638 complete data sets). We observed that soil fertility management followed similar trends across sites. However, the timing and the extent of changes were location specific, and differed primarily by the favorability/marginality of the site, and farmers’ capability to adopt technological innovations. The irrigated rice double cropping benefitted most from recent technology innovations (hybrid seeds, farm machinery), accelerating the adoption of improved fertility management practices to an aggregated level of up to 75% (mean across the six soil fertility-related management practices) at favorable sites. Most prominent were multiple splitting of mineral N and the application of mineral fertilizers other than N (P, K, Zn). At marginal sites, aggregate changes toward intensification were rather low with 35–55%, and farmers tended to intensify the non-rice component in the system by applying mineral fertilizers and organic amendments to dry season upland crops. A balanced use of nutrients will require the targeting of options to specific extrapolation domains (social-ecological target environments) based on site attributes and farmers’ resource endowment.
Barriers and Facilitators for the Donation and Acceptance of Human Breast milk: A Scoping Review
Authors: Mathias Edlin Glane , Patil Divya Sussana , Kolakemar Ashwija , Krishnan Jisha B. , Renjith Vishnu , Gudi Nachiket , Swamy Ravi Shankar , Brand Angela
Published: November 2023

Purpose of Review

Human milk is the best source of nutrients for all infants. When a mother’s own milk is unavailable, the World Health Organization suggests using donor human milk for premature neonates with or without medical complications. Exploring the barriers and facilitators for breast milk donation and its acceptability is essential for developing this intervention. A scoping review was conducted based on a methodological framework developed by Arksey and O’Malley (Int J Soc Res Methodol 8:19–32, 2005). A search was conducted in PubMed (NCBI), CINAHL (EBSCO), and Web of Science (Elsevier). A two-stage sequential screening process was adopted. Data extraction was done using a piloted data extraction form.

Recent Findings

We included 20 articles for narrative synthesis. Barriers and facilitators for donating and accepting breast milk were categorized under six themes: individual, family, community, workplace, health system, and policy-related. The common individual barriers were time requirements for BMD, personal dislike of the process, lack of knowledge, insufficient milk, negative opinions, and lack of information. Family stigma, negative rumors, less educated family members, and illness of a family member were identified as family-related barriers. Community-related barriers include cultural or religious unacceptable practices, societal taboos, and distance to milk banks. The major barriers identified in relation to the health system were lack of practical and psychological support, lack of information, storing and transportation issues, lack of knowledge among HCWs, and logistical challenges of creating a milk lab. The common work-related barriers were the lack of adequate time, philosophical objections, and incomprehension at returning to work. Policy-related barriers identified include the need for hygiene requirements, donation costs, and lack of standardized guidelines.

Making the donation process faster, providing pick-up services for donors, and community education and male partner engagement regarding breast milk donation could help to boost the acceptability of breast milk donation.
Frontal pyrometric snapshot measurements of the keyhole wall temperature in laser welding of pure aluminium
Authors: Pordzik R. , Mattulat T. , Woizeschke P.
Published: November 2023

In deep penetration laser welding, the quality of the weld seam is strongly correlated with the process dynamics. Pronounced dynamics of the melt pool and the keyhole cause defects like pores and blow-outs which negatively affect the mechanical properties of the seam. The process dynamics are primarily governed by the fluctuations of the keyhole shape. Therefore, in order to avoid the occurrence of defects in the weld seam, it is necessary to gain control over the keyhole stability by understanding the underlying physical processes that contribute to its dynamics. Besides the intensity distribution of the laser beam on the keyhole walls, the keyhole wall temperature is a crucial influencing factor when it comes to the assessment of the local metal evaporation rate and the induced local recoil pressure acting on the keyhole wall. Using small high-melting tantalum probes as measuring channels, temperatures in the vicinity of the Knudsen layer at the keyhole front wall were measured at different depths below the sample surface by means of high-speed pyrometry. For this purpose, bead on plate welding was conducted at low process velocities in the Rosenthal regime using pure aluminium (EN AW-1050A) as substrate material. It is shown for different laser powers and process velocities that the melt temperature in the vicinity of the keyhole wall lies in the range of 3000 K ± 400 K, therefore intermittently exceeding the vaporisation temperature of the substrate material. Significant correlations between the keyhole wall temperature and the laser power as well as the measuring depth could not be identified.
Current role of perioperative intravenous ketamine: a narrative review
Authors: Khan Zohair , Hameed Malika , Khan Fauzia Anis
Published: November 2023

The purpose of this review is to report on the perioperative uses of intravenous (IV) ketamine based on literature from the last five years (2018–2022). We searched MEDLINE, Embase and PubMed databases from 1st January 2018 till 15th September 2022. We primarily reviewed randomized control trials and systematic reviews with or without meta-analyses where IV ketamine was used as part of an anesthetic regimen perioperatively for general or regional anesthesia. We included studies with both pediatric and/or adult participants. We did not examine the quality of the randomized controlled trials (RCTs) included in our review. Perioperative IV ketamine consistently reduced postoperative opioid requirement especially in the early postoperative period, however, the duration of this effect was variable in different surgeries and patient populations. This effect was seen in breast, obstetric, bariatric, and orthopedic surgeries. The effect was minimal in pediatric and thoracic surgeries. It has a valuable role in multi-modal analgesic regimen, especially in orthopedic and spine procedures. Considerable heterogeneity was noted with regards to the dosage of IV ketamine. Bolus doses ranged from 0.15 to 1 mg·kg−1 and infusion doses ranged from 2 to 5 ug·kg−1·min−1. Its role in prevention of chronic post-surgical pain is still under investigation. Intravenous ketamine also reduced postoperative depressive symptoms in specific patient populations. It also reduced shivering associated with spinal anesthesia. It has a potential role in prevention of emergence agitation and postoperative delirium. In conclusion, IV ketamine has a versatile range of beneficial clinical effects in perioperative practice. The most widely studied are its analgesic effects which are of variable intensity amongst different surgical specialties and subset of patients. Despite its long history of use, fresh uses of IV ketamine continue to be reported. More trials are needed to better understand ideal dosing and patient subsets that will benefit most from these effects.
Young Adult Literature
Authors: Mygind Sarah
Published: November 2023

Young adult literature is often referred to as the originating source for film adaptations that turn into large transmedia storyworlds and franchises. This is, however, only one of the transmedia interactions involving young adult literature in modern culture. This Element unfolds these relations focusing on transmedia practices that bridge the dominant public discursive split between print based and digital media. Today print and digital products work together as well as independently in interconnected networks and these practices puncture ideas of a media hierarchy. Specifically, it is demonstrated how literature for young people take part in transmedia storytelling on a macro level but also in so-called cluster works that work as transmedia storytelling on a micro level.
Development of a context-specific trauma scale among a Palestinian adult population living amidst military violence
Authors: Mahamid Fayez , Veronese Guido , Bdier Dana
Published: November 2023

The current study aimed to develop a context-specific trauma scale in the Palestinian context. The sample of our study consisted of 490 Palestinian adults – 230 males and 260 females. Our scale ended up with 32 items to measure traumatic symptoms in the Palestinian context. Results of exploratory factor analysis and confirmatory factor analysis revealed a stable construct of a five-factor structure of the Palestinian specific-context trauma: (1) re-experiencing trauma, (2) avoidance and numbing, (3) hyperarousal, (4) somatic symptoms and (5) psychological symptoms. Reliability of the scale was further established by assessing the test–retest and internal consistency of all subscales. Convergent validity for the context-specific trauma scale was conducted by testing the association between the scale and two existing measures – the WHOQOL-BREF and the Impact of the Event Scale (IES-R). We recommend using our scale in empirical studies incorporating spoken or written disclosure about traumatic experiences. The scale should also be considered when working with clinical and non-clinical groups who have experienced politics-related trauma.
A two-phase pure slurry model for planetary cores: one-dimensional solutions and implications for Earth's F-layer
Authors: Wilczyński Fryderyk , Davies Christopher J. , Jones Christopher A.
Published: November 2023

We develop and analyse a continuum model of two-phase slurry dynamics for planetary cores. Mixed solid–liquid slurry regions may be ubiquitous in the upper cores of small terrestrial bodies and have also been invoked to explain anomalous seismic structure in the F-layer at the base of Earth's liquid iron core. These layers are expected to influence the dynamics and evolution of planetary cores, including their capacity to generate global magnetic fields; however, to date, models of two-phase regions in planetary cores have largely ignored the complex fluid dynamics that arises from interactions between phases. As an initial application of our model, and to focus on fundamental fluid dynamical processes, we consider a non-rotating and non-magnetic slurry comprised of a single chemical component with a temperature that is tied to the liquidus. We study one-dimensional solutions in a configuration set up to mimic Earth's F-layer, varying gravitational strength$R$, the solid/liquid viscosity ratio$\lambda _{\mu }$and the interaction parameter$K$, which measures friction between the phases. We develop scalings describing behaviour in the limit$R \gg 1$and$\lambda _{\mu } \gg 1$, which are in excellent agreement with our numerical results. Application to Earth's core, where$R \sim 10^{28}$and$\lambda _{\mu } \sim 10^{22}$, suggests that a pure iron slurry F-layer would contain a mean solid fraction of at most 5 %.
Molecular kinetic modelling of non-equilibrium transport of confined van der Waals fluids
Authors: Shan Baochao , Su Wei , Gibelli Livio , Zhang Yonghao
Published: November 2023

A thermodynamically consistent kinetic model is proposed for the non-equilibrium transport of confined van der Waals fluids, where the long-range molecular attraction is considered by a mean-field term in the transport equation, and the transport coefficients are tuned to match the experimental data. The equation of state of the van der Waals fluids can be obtained from an appropriate choice of the pair correlation function. By contrast, the modified Enskog theory predicts non-physical negative transport coefficients near the critical temperature and may not be able to recover the Boltzmann equation in the dilute limit. In addition, the shear viscosity and thermal conductivity are predicted more accurately by taking gas molecular attraction into account, while the softened Enskog formula for hard-sphere molecules performs better in predicting the bulk viscosity. The present kinetic model agrees with the Boltzmann model in the dilute limit and with the Navier–Stokes equations in the continuum limit, indicating its capability in modelling dilute-to-dense and continuum-to-non-equilibrium flows. The new model is examined thoroughly and validated by comparing it with the molecular dynamics simulation results. In contrast to the previous studies, our simulation results reveal the importance of molecular attraction even for high temperatures, which holds the molecules to the bulk while the hard-sphere model significantly overestimates the density near the wall. Because the long-range molecular attraction is considered appropriately in the present model, the velocity slip and temperature jump at the surface for the more realistic van der Waals fluids can be predicted accurately.
The association between dietary intake of macro- and micronutrients and multimorbidity: a cross-sectional study in Cyprus
Authors: Kyprianidou Maria , Chrysostomou Stavri , Andreou Kosmia , Alexandrou Agni , Panagiotou Rafaella , Christophi Costas A. , Giannakou Konstantinos
Published: November 2023

Research on the link between diet and multimorbidity is scarce, despite significant studies investigating the relationship between diet and individual chronic conditions. This study examines the association of dietary intake of macro- and micronutrients with multimorbidity in Cyprus's adult population. It was conducted as a cross-sectional study, with data collected using a standardised questionnaire between May 2018 and June 2019. The questionnaire included sociodemographic information, anthropometrics, medical history, dietary habits, sleep quality, smoking habits, and physical activity. The participants were selected using a stratified sampling method from adults residing in the five government-controlled municipalities of the Republic of Cyprus. The study included 1137 adults with a mean age of 40⋅8 years, of whom 26 % had multimorbidity. Individuals with multimorbidity consumed higher levels of sodium (P = 0⋅009) and vitamin A (P = 0⋅010) compared to those without multimorbidity. Additionally, higher fibre and sodium intake were also observed in individuals with at least one chronic disease of the circulatory system or endocrine system, compared to those with no chronic diseases in these systems (P < 0⋅05). Logistic regression models revealed that individuals with ≥2 chronic diseases compared to 0 or 1 chronic disease had higher fat intake (OR = 1⋅06, 95 % CI: 1⋅02, 1⋅10), higher iron intake (OR = 1⋅05, 95 % CI: 1⋅01, 1⋅09), lower mono-unsaturated fat intake (OR = 0⋅91, 95 % CI: 0⋅86, 0⋅96), and lower zinc intake (OR = 0⋅98, 95 % CI: 0⋅96, 0⋅99). Future research should replicate these results to further explore the intricate relationships between nutrient intake and multimorbidity. Our study's findings suggest that specific dietary components may contribute to preventing and managing multimorbidity.
The effect of tissue mobilization and stage of lactation on energy partitioning in lactating sows: an analysis of commercial data
Authors: Gasa Josep , Capalbo S. , Ellis Jennifer , Sola David , France James
Published: November 2023

The objective of this paper was to investigate how the predicted level of body energy mobilized and the stage of lactation affects performance and energy partitioning in lactating sows kept under commercial conditions. Seventy-seven lactating sows from three consecutive batches were weaned at 28 d and all measures were taken over the first 20 d. Total feed consumption was measured and sows’ live weight was registered when entering the lactation facilities and at 21 d of lactation. Blood samples were collected at farrowing and once a week thereafter. Net energy (NE) mobilization or loss was calculated by difference using the general NRC equation for ME partitioning. Compared to low mobilizers (low NE loss values), high mobilizing sows had lower feed intake and higher loss of live weight, body fat and body protein. High mobilizers also weaned more piglets and had heavier litters than low mobilizers. Energy mobilization (NE loss) was higher from day 1 to 10 of lactation compared to day 11 to 20, and the difference in mobilized energy between high and low mobilizing sows was also higher in the first than in the second half of lactation. Body weight and back fat thickness losses were significantly correlated with NE loss. A more accurate prediction of the changes in live weight or back fat thickness over lactation should help better predict total amount of energy mobilized, and more research is needed to assess the relative contribution of lean and fat to mobilized tissue.
John Owen's Lost Huguenot Letters: French Reformed Protestants and the Reception of Congregational English Puritan Ecclesiology and Politics
Authors: QUIBELL ADAM
Published: November 2023

John Owen (1616–83) was one of the foremost English Puritans of the seventeenth century. His story has been largely limited to events in Britain. The letters examined in this article, translated from the French, reveal Owen's reputation and activity among Huguenots at the end of Oliver Cromwell's Protectorate. Responding to critics of English religion like Moïse Amyraut, they highlight the largely neglected internationality of Interregnum religion and politics in which Owen participated through epistolary and print culture. They display the apocalyptic themes behind attempts at international Protestant union where ecclesiological debates over the nature of synods, toleration, political sovereignty and Church-State relations were decisive.
Distinct neurofunctional alterations during motivational and hedonic processing of natural and monetary rewards in depression – a neuroimaging meta-analysis
Authors: Bore Mercy Chepngetich , Liu Xiqin , Gan Xianyang , Wang Lan , Xu Ting , Ferraro Stefania , Li Liyuan , Zhou Bo , Zhang Jie , Vatansever Deniz , Biswal Bharat , Klugah-Brown Benjamin , Becker Benjamin
Published: November 2023

Reward processing dysfunctions are considered a candidate mechanism underlying anhedonia and apathy in depression. Neuroimaging studies have documented that neurofunctional alterations in mesocorticolimbic circuits may neurally mediate these dysfunctions. However, common and distinct neurofunctional alterations during motivational and hedonic evaluation of monetary and natural rewards in depression have not been systematically examined. Here, we capitalized on pre-registered neuroimaging meta-analyses to (1) establish general reward-related neural alterations in depression, (2) determine common and distinct alterations during the receipt and anticipation of monetary v. natural rewards, and, (3) characterize the differences on the behavioral, network, and molecular level. The pre-registered meta-analysis (https://osf.io/ay3r9) included 633 depressed patients and 644 healthy controls and revealed generally decreased subgenual anterior cingulate cortex and striatal reactivity toward rewards in depression. Subsequent comparative analyses indicated that monetary rewards led to decreased hedonic reactivity in the right ventral caudate while natural rewards led to decreased reactivity in the bilateral putamen in depressed individuals. These regions exhibited distinguishable profiles on the behavioral, network, and molecular level. Further analyses demonstrated that the right thalamus and left putamen showed decreased activation during the anticipation of monetary reward. The present results indicate that distinguishable neurofunctional alterations may neurally mediate reward-processing alterations in depression, in particular, with respect to monetary and natural rewards. Given that natural rewards prevail in everyday life, our findings suggest that reward-type specific interventions are warranted and challenge the generalizability of experimental tasks employing monetary incentives to capture reward dysregulations in everyday life.
Estimating the ‘Missing’ Houses of Silchester
Authors: Ortman Scott , Hanson John
Published: November 2023

Estimating the numbers of residences, and thus the residential densities and populations, of ancient settlements remains a significant problem. This is true even for ‘greenfield’ sites due to the differential visibility of structures made of different materials in aerial and geophysical surveys. In this paper, we take advantage of statistical relationships among elements of the built environments of Roman cities in Britannia and more broadly across the Empire, to estimate the total number of buildings, total population and population density of Silchester. The results indicate that the current site plan dramatically under-represents these values. We also consider the implications of our results for broader discussions of urbanism in Britannia.
AN EARLY CONSUMER REVOLUTION IN HISPANIC AMERICA? CONSUMPTION OF ASIAN GOODS BY THE COMMONERS IN 18TH-CENTURY MEXICO
Authors: Dobado Rafael , de Pinedo Nadia Fernández
Published: November 2023

Was there an early consumer revolution in Hispanic America? This article presents varied evidence supporting an affirmative answer to this question, especially regarding the case of New Spain. The inauguration of the Manilla Galleon trade route across the Pacific Ocean in 1565 was decisive in this respect. It made it possible that Asian goods (more or less finished silk and cotton textiles, porcelain, lacquerware, ivory religious images, furniture and spices, mainly) experienced an early diffusion throughout New Spain after arriving in Acapulco. This innovation in consumption patterns was adopted first by the elites, not much later, by the intermediate classes and, rather soon than not, by the commoners. Primary (i.e. Avalúos of the galleons' cargo) and secondary sources permit quantitatively exploring the possibilities of consumption of Asian goods by unprivileged segments of New Spain's population. We find that a non-negligible number of those goods were accessible to Mexico City labourers. Thus, it may be inferred that upper segments of society accessed it earlier and more easily. Therefore, New Spain should be included in any global narrative of the changes in consumption during the Early Modern Era.
China on Campus: A Conversation with China Scholars of Asian Heritage
Authors: Chen Dan , Han Rongbin , Yasuda John
Published: November 2023

Increasing tensions between the United States and China, a rise in anti-Asian sentiment, and the risk of government surveillance has dramatically altered the teaching and research contexts for scholars of Chinese politics. In this conversation, Dan Chen (University of Richmond), Rongbin Han (University of Georgia), and John Yasuda (Johns Hopkins University) discuss how questions of identity, politics, and security have affected classroom dynamics and their future research endeavors.
Researching China in Hard Times
Authors: Truex Rory
Published: November 2023

In the spring of 2018, Sheena Greitens and I conducted the China Scholar Research Experience Survey, a survey of 562 China scholars in the social sciences.1 The goal of the survey was to understand the incidence rate of different repressive experiences in the conduct of research. We found that at the time, such incidents were a “rare but real” phenomenon. Approximately 9% of respondents stated that they had been “invited to tea” by authorities within the past 10 years; 26% of scholars who conduct archival research reported having had issues with access; and 5% of researchers cited some difficulty obtaining a visa (Greitens and Truex 2020).
Researching China’s Development and Globalization in an Era of US-China Tensions
Authors: Hsueh Roselyn
Published: November 2023

The role that China is perceived to present for the global economy—much less global security—has changed remarkably since China’s accession to the World Trade Organization (WTO) in December 2001. During the height of neoliberalism and third-wave democracies, China appeared more open to foreign capital than the developmental states of East Asia, which had restricted foreign direct investment (FDI) in favor of domestic industrialization during a comparable stage of economic development. Through the first 15 years of China’s WTO membership, many in academia and the policy world depicted a modernizing China undergoing market transition, in parallel to Eastern European countries after the collapse of the Soviet Union.
Reframing Sound Shapes in Spectromorphological Composition: Notating perspectival space through spherical, Euclidean and Cartesian-coordinate systems
Authors: Cross Tiernan
Published: November 2023

This paper examines Smalley’s preliminary taxonomy of the sound shape and the subsequent application of graphical notation in electroacoustic music. It will demonstrate ways in which spatial categorisations of the morphological sound shape have remained relatively untouched in academia, despite a codependency of frequency, space and time. Theoretical examples and existing visualisations of the sound shape will be considered as a starting point, to determine why the holistic visualisation of space is warranted. A notational system addressing the codependency between spatial and spectral sound shapes will be presented, with reference to its context in Cartesian-coordinate sound environments. This method of electroacoustic notation will incorporate the visualisation of Smalley’s categorisation of spatial sound shapes and ideas of spatial gesture, texture and distribution within Smalley’s composed and listening spaces. This visualisation and notation of composed and listening spaces will demonstrate that audio technologies are imperative drivers in the future analysis and understanding of the sound shape. It will measure the modulation of spatial sound shape properties for Cartesian (height, width, depth) and spherical (azimuth and altitude) across linear temporality, to better represent the complete form of Smalley’s sound shape. This spatial notation will aid the rounded visualisation of Smalley’s morphology, motion, texture, gesture, structure and form. Use of this notational framework will illustrate ways in which a new tool to score electroacoustic sound shapes can inform new practices in computer music composition.
Radio: An instrument in art – with reference to selected works by Polish artists
Authors: Misiak Tomasz , Olejniczak Marcin
Published: November 2023

This article explores the role of the radio as an artistic instrument. It discusses both contemporary and historical art experiments, namely those where the sound of the radio or the form of radio reception is an important aspect of the final work. We examine the question, ‘What does it mean for a radio to be an instrument?’ And to clarify, we mean any kind of instrument, not just a musical one. To answer this question, this article focuses on the concepts and theory of those Polish artists who have used radio in their artwork, either as the source of a particular type of sound or as a medium that collects and transmits the sound of its surroundings.
‘The night before beg'd ye queens's pardon and his brother's’: the apostrophe in the history of English
Authors: CALLE-MARTÍN JAVIER , PACHECO-FRANCO MARTA
Published: November 2023

The apostrophe was introduced into the English orthographic system by the mid sixteenth century as a printer's mark especially designed ‘for the eye rather than for the ear’ (Sklar 1976: 175; Little 1986: 15). Whereas the uses of the apostrophe today are limited to the Saxon genitive construction (the woman's book), to verbal contractions (you'll ‘you will’ or you're ‘you are’) and to other formulaic expressions (o'clock), its early uses also included other cases of elision and some abbreviated words (Parkes 1992: 55‒6; Beal 2010a: 58). Among this plethora of uses, perhaps one of the most distinctive functions of this symbol is the indication of the genitive construction, which has no full form in Present-day English after the progressive extinction of the genitive case affix. Such a development could have also happened in the regular past morpheme, but its outcome differed, as it continues to be spelled out today.

The present article is then concerned with the standardisation of the apostrophe in the English orthographic system in the period 1600–1900 and pursues the following objectives: (a) to study the use and omission of the apostrophe in the expression of the past tense, the genitive case and the nominative plural in the period; (b) to assess the relationship between the three uses and their likely connections; and (c) to evaluate the likely participation of grammarians in the adoption and the rejection of each of these phenomena in English. The source of evidence for this corpus-based study comes from A Representative Corpus of Historical English Registers (ARCHER 3.2, Denison & Yáñez-Bouza 2013), sampling language use in different genres and text types in the historical period 1700–1900. Additionally, the Early English Books Online corpus (EEBO, Davies 2017) has also been used as material to investigate the early uses of the possessive apostrophe in the late sixteenth century. A preliminary data analysis confirms the second half of the seventeenth century as the period that saw the definite rise of the genitive apostrophe in English, refuting the early assumptions which considered it to be an eighteenth-century development (Crystal 1995: 68; Lukač 2014: 3). The results also suggest that this phenomenon was to some extent associated with the decline of the apostrophe in other environments, more particularly in the expression of the regular past tense forms. Moreover, there seems to be no indication that standardisation emerged from linguistic prescription; instead, grammars seem to have been shaped after use.
Investigating electromagnetic scattering characteristics based on a nonlinear sea surface
Authors: Liu Xunchao , Miao Hongli , Chen Jiajie
Published: November 2023

Establishing a precise electromagnetic scattering model of surfaces is of great significance for comprehending the underlying mechanics of synthetic aperture radar (SAR) imaging. To describe surface electromagnetic scattering more comprehensively, this paper established a nonlinear integral equation model with the Creamer model and bispectrum (IEM-C). Based on the IEM-C model, the effect of parameters, such as radar wave incidence angle, wind speed and direction of sea surfaces, and different polarization modes on the backscattering coefficients of C-band radar waves, was systematically evaluated. The results show that the IEM-C model can characterize both the vertical nonlinear features due to wave interactions and the horizontal nonlinear features due to the wind direction. The sensitivity of the sea surface backscattering coefficient in the IEM-C model to nonlinear effects varies with different incident angles. At the incident angle of 30°, the IEM-C model exhibits the most significant nonlinear effects. The nonlinear effects of the IEM-C model vary under different wind speeds. By comparing with the measured data, it is proved that the IEM-C model is closer to the real sea surface scattering situation than the IEM model.
A Squire Index Update: Stability and Change in Legislative Professionalization, 1979–2021
Authors: Squire Peverill
Published: November 2023

The Squire Index measuring the professionalization levels of American state legislatures was created three decades ago. In this note, I explain how the 2021 update was compiled. I then document the index’s stability over the years for which it has been measured, present alternative measures to explore a problematic aspect of the index, and finally examine how each of the index’s three components has moved relative to Congress between 1979 and 2021.
Direct Sampling for Spatially Variable Extreme Event Generation in Resampling‐Based Stochastic Weather Generators
Authors: Guevara Jorge , Garcia Maria , Avegliano Priscilla , Lima Debora , Queiroz Dilermando , Macedo Maysa , Tizzei Leonardo , Szwarcman Daniela , Zadrozny Bianca , Watson Campbell , Jones Anne
Published: November 2023

Resampling‐based weather generators simulate new time series of weather variables by reordering the observed values such that the statistics of the simulated data are consistent with the observed ones. These generators are fully data‐driven, easy to implement, and capable of reproducing the dynamics among weather variables. However, although the simulated time series is new, the weather fields produced at arbitrary time steps are replicas of those found in observations, limiting the spatial variability of simulations and preventing the generation of extreme weather fields beyond the range of observed values. To address these limitations, we propose the integration of the Direct Sampling algorithm—a data‐driven method for producing simulations—into resampling‐based weather generators. By incorporating Direct Sampling as a post‐processing step on the outputs of the weather generator, we enhance the spatial variability of the generated weather fields and enable the generation of extreme weather fields. We introduce an approach for generating out‐of‐sample extreme weather fields using Direct Sampling. This method involves utilizing a set of control points in conjunction with Direct Sampling, where the values of these control points are informed by return period analysis. The proposed approach is validated using precipitation, temperature, and cloud cover weather fields in a region of northwest India. The experimental results confirm that Direct Sampling enhances the spatial variability of the weather fields and facilitates the generation of out‐of‐sample precipitation fields that accurately adhere to the spatial statistics provided by return precipitation level maps, as well as the observed precipitation weather field employed in the analysis.
Nonstationarity in High and Low‐Temperature Extremes: Insights From a Global Observational Data Set by Merging Extreme‐Value Methods
Authors: Nerantzaki Sofia D. , Papalexiou Simon Michael , Rajulapati Chandra Rupa , Clark Martyn P.
Published: November 2023

We merge classical extreme value methods to extract high (high temperatures (HT)) and low (low temperatures (LT)) temperatures and form time series having at least one extreme value per year. Observed daily maximum and minimum temperature records are used from 4,797 quality‐controlled, global, surface stations over 1970–2019. We assess changes in the magnitude and frequency of extreme temperatures by introducing and applying novel methods that exploit the definition of stationarity. Analysis shows significant increasing (40.6% of the stations) and decreasing (41.1%) trends in the frequency of high and LT, respectively, and increasing trends in both high‐ and low‐temperature values (35.6% and 49.7%). Globally, HT and LT frequencies are increasing and decreasing, respectively, by 0.9% and 1.1% per year, relative to the expected frequencies under the assumption of stationarity. The global mean annual HT and LT magnitudes are increasing by 0.004 and 0.016°C/year compared to the expected ones under stationarity. The results indicate that the assumption of stationarity fails to explain the observed changes. The proposed methods are an alternative approach to classical extreme value methods and a useful tool to reveal changes in extremes in the era of earth‐system change.