bluuebunny/crossref_metadata_2025 huggingface dataset:
San Diego Bilgelik Ölçeği: Uyarlama, geçerlik ve güvenirlik çalışması
Authors: AKFIRAT Osman Nejat , AKKAYA Ahmet
Published: December 2022

Bu çalışmanın amacı San Diego Bilgelik Ölçeği’nin (SDBÖ) Türkçeye uyarlanmasıdır. SDBÖ, Thomas vd. tarafından 2019 yılında geliştirilmiştir. SDBÖ’nin Türkçeye uyarlanabilmesi için öncelikle yazardan izin alınmış, ardından ölçek Rehberlik ve Psikolojik Danışmanlık alanından üç öğretim üyesi tarafından İngilizceden Türkçeye çevrilmiştir. Üç uzman tarafından yapılan çevirilerden oluşturulan Türkçe form, alan uzmanı olan üç farklı öğretim üyesi tarafından tekrar İngilizceye çevrilmiştir. Çeviri sonrası form ile orijinal İngilizce form karşılaştırılarak çeviri uygunluğu kontrol edilmiştir. Daha sonra oluşturulan form 127 kişilik bir gruba uygulanmış ve ölçekteki ifadelerin dil ve anlaşılırlığı test edilmiş ve nihai form oluşturulmuştur. Bu çalışma, 16-56 yaşlarındaki 221 bireyin katılımıyla yürütülmüştür. Ölçeğin Türkçe formunun geçerliliği doğrulayıcı faktör analizi ile incelenmiştir. DFA sonucu elde edilen uyum indeksleri (χ2(237) = 404.96, χ2/sd= 1.71, GFI=.87, CFI= .93, IFI=.93, NNFI=.92 SRMR=.071 ve RMSEA=.057), ölçeğin orijinal faktör yapısına ilişkin tanımlanan altı faktörlü (sosyal danışmanlık, kararlılık, olumlu sosyal davranış, duygusal düzenleme, farklı değerlere tolerans ve içgörü) modelin doğrulandığını göstermektedir. Ölçeğin güvenirlik düzeyini belirlemek için ise tüm ölçek ve alt boyutlara ilişkin Cronbach Alpha değerleri ile maddelere ilişkin madde toplam korelasyon değerleri hesaplanmış ve test tekrar test analizi yapılmıştır. Cronbach α güvenirlik katsayısı birleşik ölçek için .82, alt ölçekler için .47 ile .71 aralığında hesaplanmıştır. Ölçeğin alt boyutlarına ilişkin test-tekrar test güvenirlik korelasyon değerleri 0.71 ila 0.79 arasında değişmektedir. Elde edilen bulgularla bu ölçeğin Türkiye’de 16-56 yaş arası bireylerin bilgelik düzeylerinin belirlenmesinde kullanılabilecek, güvenirliği ve geçerliği yüksek ölçmeler yapan bir ölçme aracı olduğu ortaya konulmuştur.
ARTIFICIAL INTELLIGENCE IN DETECTING ATHEROSCLEROSIS PLAQUES AND ELECTROMAGNETIC THERAPY TO ALTER CHOLESTEROL LEVEL
Authors:   Program Faculty of Medicine, Soegijapranata Catholic University Indonesia, Pramesuari Florentina D
Published: December 2022

Introduction: Artificial Intelligence (AI) application in healthcare fields include matching patient symptoms to appropriate physician, helped to diagnose patients, determine patient’s prognosis, drug discovery, translating languages, and organize data. AI technology used in analysis and diagnosing coronary atherosclerotic plaques has increased annually. There are studies suggested that extremely low-frequency electromagnetic fields exposure can affect lipid metabolism. Purpose: To use applied AI in a device that can both identifying atherosclerosis in blood vessel and treat with low-frequency electromagnetic wave. Method: Experiments carried out using a device to detect and treat blockage of blood vessels by emitting electromagnetic signals. This tool is an AI breakthrough that not only includes a diagnostic function, but can also perform electromagnetic therapy. Result: Previous studies mentioned that AI can be applied to identify atherosclerosis. There are some studies that states low-frequency electromagnetic waves can alter HDL and cholesterol levels in blood. Larger studies are needed to combine both function in identify atherosclerosis plaques and electromagnetic therapy. Conclusion: Rapidly developing AI technology can be applied to identify atherosclerosis plaque and treat them. Further studies are required to provide definitive proof of electromagnetic wave effects on the removal of cholesterol from plaques using thermal effects or raising HDL concentrations in blood.
RELATIONSHIP BETWEEN PARITY AND LABOR WITH BABY BLUES EVENTS IN CLINIC YOSTAVAN MEDIKA SIDOARJO
Authors:   Faculty of Medicine, Widya Mandala Catholic University Surabaya Indonesia, Ardianis Anastasia R , Djaputra Maria E ,   Department of Neurology, Faculty of Medicine, Widya Mandala Surabaya Catholic University Indonesia, Tandyono Venny ,   Department of Dermatology and Venerology, Faculty of Medicine, Widya Mandala Catholic University Surabaya Indonesia
Published: December 2022

Introduction: Parity is the number of children born to the mother and able to live outside the womb. Labor is the birth of the fetus and placenta in sufficient number of month. Maternity blues or post partum blues or baby blues is a depressive syndrome that occurs whitin 14 days which is not too long and will disappear over time whitout treatment.Risk factors in the form of labor due to physical exhaustion during the labor process, and bleeding that can affect the activity of the mother after childbirth. The risk factor is parity due to their lack of experience as primiparous mothers and their inability to properly care for their babies, primiparous mother are more likely to experience the baby blues than multiparous mother. Researchers are interested in conducting research on “The Relationship between Parity and Labor with the Incidence of baby blues at the Clinic Yostavan Medika Prambon, Sidoarjo”. Purpose: Knowing the relationship between parity and labor with the incidence of baby blues in Clinic Yostavan Medika sidoarjo Method: Cross sectional is used in this research and the sampling method was purposive sampling. This study used the EPDS questionnairewith logistic regression analysis techniques. Result: In the univariate analysis using the bivariate logistic regression test, significant results were obtained with a value of 0,011 which means that parity and delivery are related to the incidence of baby blues. Respondents who experienced the baby blues with primipara parity were as many as 57,6%. Respondents with a normal delivery process who experienced the baby blues 56,7%. Based on the multivariate logistic regression analysis test, the results showed no significant p value = 0.460 which means that parity and delivery have no effect on baby blues. Conclusion: There is not relationship between parity and labor with the incidence of baby blues at Clinic Yostavan Medika, Sidoarjo
COVID-19 THERAPY: COMPARISON EFFECTIVITY BETWEEN REMDESIVIR AND FAVIPIRAVIR
Authors:   Faculty of Medicine, Widya Mandala Surabaya Catholic Universit Indonesia, Go Nevan , Mellow Prettysun A ,   Department of Internal Medicine, Medical Faculty Widya Mandala Surabaya Catholic University Indonesia, Dewi Bernadette Dian Novita ,   Department of Pharmacology and Therapy, Medical Faculty Widya Mandala Surabaya Catholic University Indonesia
Published: December 2022

ntroduction: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) is the virus that causes Coronavirus Disease 2019 (COVID-19), a disease of global concern(1). Remdesivir and favipiravir are antiviral drugs that are considered COVID19 therapy, as described in Indonesia's 3rd COVID-19 Management Guidelines. They have a similar mechanism, specifically by inhibiting RNA dependent RNA polymerase of the virus (3). Several studies have reported that patients who were treated with these antivirals had a shorter hospital stays (4–6). However, the comparison of efficacy between remdesivir and favipiravir is still unknown. Methods: An observational analytic study was done using a retrospective cohort design. Eighty-eight medical records of COVID-19 patients between January 2021 to August 2021 are collected by consecutive sampling techniques, and this research was carried out at Gotong Royong Hospital Surabaya. Results: Based on the statistical analysis test, there was no clinical improvement difference found, neither patients received remdesivir nor favipiravir based on their clinical manifestations, such as ventilation support and chest X-ray, measured by WHO ordinal scale (p=0,486 ; p>0,05 on the first week and p=0,942 ; p>0,05 on the second week). Conclusions: Improved clinical manifestations were seen in the second week of therapy, either in patients who received remdesivir or favipiravir, but there was no significant effectivity difference between those drugs.
Üremik Kaşıntı Nedeniyle Renal Replasman Tedavisi Planlanan Hastanın Skabiyes Tedavisi Sonrası Düzelip Diyalizsiz Takibi
Authors: TOPRAK Ömer , ŞEN Hacer , YILDIRIM ÖZKAN Burcu , DOĞAN Sümeyye Hilal
Published: December 2022

Kronik böbrek yetmezliği hastalarında üremik kaşıntı sık görülen bir bulgudur. Ancak kronik böbrek yetmezliği olan bir hastada kaşıntının olması her zaman üremiye bağlı değildir. Hastadaki kaşıntıya sebep olabilecek böbrek dışı nedenler de araştırılmalıdır. Kaşıntıyla gelen hastada düşünülecek nedenlerden birisi de skabiyestir. Bu yazımızda evre 5 kronik böbrek yetmezliği olup başka merkezlerde kaşıntısı üremik kaşıntıya bağlandığı için böbrek nakline veya diyalize girmesine karar verilen ve sonrasında tarafımızca skabiyes tanısı konulup diyaliz veya nakil olmadan takip edilen olguyu sunuyoruz.
Application of polymerized porcine hemoglobin in the ex vivo normothermic machine perfusion of rat livers
Authors: Li Bin , Zhang Jie , Shen Chuanyan , Zong Tingting , Zhao Cong , Zhao Yumin , Lu Yunhua , Sun Siyue , Zhu Hongli
Published: December 2022

Background: In contrast to traditional static cold preservation of donor livers, normothermic machine perfusion (NMP) may reduce preservation injury, improve graft viability and potentially allows ex vivo assessment of graft viability before transplantation. The polymerized porcine hemoglobin is a kind of hemoglobin oxygen carrier prepared by crosslinking porcine hemoglobin by glutaraldehyde to form a polymer. The pPolyHb has been proved to have the ability of transporting oxygen which could repair the organ ischemia-reperfusion injury in rats.

Objective: In order to evaluate the effectiveness of rat liver perfusion in vitro based on pPolyHb, we established the NMP system, optimized the perfusate basic formula and explored the optimal proportion of pPolyHb and basal perfusate.

Methods: The liver was removed and perfused for 6 h at 37°C. We compared the efficacy of liver perfusion with different ratios of pPolyHb. Subsequently, compared the perfusion effect using Krebs Henseleit solution and pPolyHb perfusate of the optimal proportion, and compared with the liver preserved with UW solution. At 0 h, 1 h, 3 h and 6 h after perfusion, appropriate samples were collected for blood gas analysis and liver injury indexes detection. Some tissue samples were collected for H&E staining and TUNEL staining to observe the morphology and detect the apoptosis rate of liver cells. And we used Western Blot test to detect the expression of Bcl-2 and Bax in the tissues.

Results: According to the final results, the optimal addition ratio of pPolyHb was 24%. By comparing the values of Bcl-2/Bax, the apoptosis rate of pPolyHb group was significantly reduced. Under this ratio, the results of H&E staining and TUNEL staining showed that the liver morphology was well preserved without additional signs of hepatocyte ischemia, biliary tract injury, or hepatic sinusoid injury, and hepatocyte apoptosis was relatively mild.

Conclusion: Through the above-mentioned study we show that within 6 h of perfusion based on pPolyHb, liver physiological and biochemical activities may essentially be maintained in vitro. This study demonstrates that a pPolyHb-based perfusate is feasible for NMP of rat livers. This opens up a prospect for further research on NMP.
Electrospun hybrid nanofibers: Fabrication, characterization, and biomedical applications
Authors: Abadi Banafshe , Goshtasbi Nazanin , Bolourian Saman , Tahsili Jaleh , Adeli-Sardou Mahboubeh , Forootanfar Hamid
Published: December 2022

Nanotechnology is one of the most promising technologies available today, holding tremendous potential for biomedical and healthcare applications. In this field, there is an increasing interest in the use of polymeric micro/nanofibers for the construction of biomedical structures. Due to its potential applications in various fields like pharmaceutics and biomedicine, the electrospinning process has gained considerable attention for producing nano-sized fibers. Electrospun nanofiber membranes have been used in drug delivery, controlled drug release, regenerative medicine, tissue engineering, biosensing, stent coating, implants, cosmetics, facial masks, and theranostics. Various natural and synthetic polymers have been successfully electrospun into ultrafine fibers. Although biopolymers demonstrate exciting properties such as good biocompatibility, non-toxicity, and biodegradability, they possess poor mechanical properties. Hybrid nanofibers from bio and synthetic nanofibers combine the characteristics of biopolymers with those of synthetic polymers, such as high mechanical strength and stability. In addition, a variety of functional agents, such as nanoparticles and biomolecules, can be incorporated into nanofibers to create multifunctional hybrid nanofibers. Due to the remarkable properties of hybrid nanofibers, the latest research on the unique properties of hybrid nanofibers is highlighted in this study. Moreover, various established hybrid nanofiber fabrication techniques, especially the electrospinning-based methods, as well as emerging strategies for the characterization of hybrid nanofibers, are summarized. Finally, the development and application of electrospun hybrid nanofibers in biomedical applications are discussed.
Upregulated ENC1 predicts unfavorable prognosis and correlates with immune infiltration in endometrial cancer
Authors: He Lingling , He Wenjing , Luo Ji , Xu Minjuan
Published: December 2022

A better knowledge of the molecular process behind uterine corpus endometrial carcinoma (UCEC) is important for prognosis prediction and the development of innovative targeted gene therapies. The purpose of this research is to discover critical genes associated with UCEC. We analyzed the gene expression profiles of TCGA-UCEC and GSE17025, respectively, using Weighted Gene Co-expression Network Analysis (WGCNA) and differential gene expression analysis. From four sets of findings, a total of 95 overlapping genes were retrieved. On the 95 overlapping genes, KEGG pathway and GO enrichment analysis were conducted. Then, we mapped the PPI network of 95 overlapping genes using the STRING database. Twenty hub genes were evaluated using the Cytohubba plugin, including NR3C1, ATF3, KLF15, THRA, NR4A1, FOSB, PER3, HLF, NTRK3, EGR3, MAPK13, ARNTL2, PKM2, SCD, EIF5A, ADHFE1, RERGL, TUB, and ENC1. The expression levels of NR3C1, PKM2, and ENC1 were shown to be adversely linked with the survival time of UCEC patients using univariate Cox regression analysis and Kaplan-Meier survival calculation. ENC1 were also overexpressed in UCEC tumor tissues or cell lines, as shown by quantitative real-time PCR and Western blotting. Then we looked into it further and discovered that ENC1 expression was linked to tumor microenvironment and predicted various immunological checkpoints. In conclusion, our data indicate that ENC1 may be required for the development of UCEC and may serve as a future biomarker for diagnosis and therapy.
Blood-stage antiplasmodial activity and oocyst formation-blockage of metallo copper-cinchonine complex
Authors: Morais Camila Martins Gomes , Brito Ramayana Morais de Medeiros , Weselucha-Birczyńska Aleksandra , Pereira Valeska Santana de Sena , Pereira-Silva Jordam William , Menezes Alexandre , Pessoa Felipe Arley Costa , Kucharska Martyna , Birczyńska-Zych Malwina , Ríos-Velásquez Claudia María , Andrade-Neto Valter Ferreira de
Published: December 2022

In the fight against malaria, the key is early treatment with antimalarial chemotherapy, such as artemisinin-based combination treatments (ACTs). However, Plasmodium has acquired multidrug resistance, including the emergence of P. falciparum strains with resistance to ACT. The development of novel antimalarial molecules, that are capable of interfering in the asexual and sexual blood stages, is important to slow down the transmission in endemic areas. In this work, we studied the ability of the mettalo copper-cinchonine complex to interfere in the sexual and asexual stages of Plasmodium. The tested compound in the in vitro assay was a cinchonine derivative, named CinCu (Bis[Cinchoninium Tetrachlorocuprate(II)]trihydrate). Its biological functions were assessed by antiplasmodial activity in vitro against chloroquine-resistant P. falciparum W2 strain. The mice model of P. berghei ANKA infection was used to analyze the antimalarial activity of CinCu and chloroquine and their acute toxicity. The oocyst formation-blocking assay was performed by experimental infection of Anopheles aquasalis with P. vivax infected blood, which was treated with different concentrations of CinCu, cinchonine, and primaquine. We found that CinCu was able to suppress as high as 81.58% of parasitemia in vitro, being considered a molecule with high antiplasmodial activity and low toxicity. The in vivo analysis showed that CinCu suppressed parasitemia at 34% up to 87.19%, being a partially active molecule against the blood-stage forms of P. berghei ANKA, without inducing severe clinical signs in the treated groups. The transmission-blocking assay revealed that both cinchonine and primaquine were able to reduce the infection intensity of P. vivax in A. aquasalis, leading to a decrease in the number of oocysts recovered from the mosquitoes’ midgut. Regarding the effect of CinCu, the copper-complex was not able to induce inhibition of P. vivax infection; however, it was able to induce an important reduction in the intensity of oocyst formation by about 2.4 times. It is plausible that the metallo-compound also be able to interfere with the differentiation of parasite stages and/or ookinete-secreted chitinase into the peritrophic matrix of mosquitoes, promoting a reduction in the number of oocysts formed. Taken together, the results suggest that this compound is promising as a prototype for the development of new antimalarial drugs. Furthermore, our study can draw a new pathway for repositioning already-known antimalarial drugs by editing their chemical structure to improve the antimalarial activity against the asexual and sexual stages of the parasite.
The oral microbiome in young women at different stages of periodontitis: Prevotella dominant in stage III periodontitis
Authors: Zhao Yaqiong , Feng Yunzhi , Ye Qin , Hu Jing , Feng Yao , Ouyang Zeyue , Zhao Jie , Chen Yun , Tan Li , Chen Ningxin , Dusenge Marie Aimee , Su Xiaolin , Guo Yue
Published: December 2022

Objective

Periodontitis progression is related to the dynamic dysbiosis of oral microbiome. We identified the dominant bacteria and the potential pathway in young women with stage-III periodontitis.

Materials and methods

Samples of subgingival plaque were collected from 26 young women with periodontitis (20 with stage-I and 6 with stage-III). Using 16S rRNA-sequencing, we determined the variation in oral bacterial communities of the two groups, and identified the dominant bacteria of each group. We used the Kyoto Encyclopedia of Genes and Genomes (KEGG) database to evaluate the signaling pathways related to the difference in oral bacterial composition. The role of the dominant bacteria of stage-III periodontitis was investigated in vivo and in vitro using an endoplasmic reticulum stress inhibitor.

Results

Young women with stage-I periodontitis had higher values for the Chao1 Index, Observed Species and Phylogenetic Diversity Whole Tree Index than those for women with stage-III periodontitis. β-diversity analyses revealed that samples could be divided into different groups according to the periodontitis stage. The most representative biomarkers of stage-III periodontitis in young women were bacteria of the phylum Bacteroidetes, its order, family and genera Bacteroidales, Prevotellaceae and Prevotella. The KEGG database revealed that the change in oral bacterial composition of young women with stage-III periodontitis may be related to protein processing in an endoplasmic reticulum pathway. Salubrinal (an endoplasmic reticulum stress regulator) controlled expression of Runx2, Col1a1, Ocn in mouse bone-marrow mesenchymal cells. Salubrinal administration showed that moderate endoplasmic reticulum stress inhibited alveolar bone loss in periodontitis induced by Prevotella intermedia lipopolysaccharide.

Conclusion

Differences between periodontitis stages were noted and bacteria of Prevotella species were abundant in young women with stage-III periodontitis. This phenomenon was related to protein processing in an endoplasmic reticulum pathway.
Environmental crime and the harm prevention criminalist
Authors: White Rob
Published: December 2022

The role of the ‘pracademic’ comes in the fore in the interface between academia and environmental protection. This article explores the translation of evidence-based research and theoretical innovation in environmental crime prevention into ground level practice. Crime prevention as applied to illegal fishing forms the initial focus of the discussions. This is followed by discussion of pracademics and the importance of combining academic work and practitioner experience as part of applied criminology. The paper then discusses the potential role of a ‘harm prevention criminalist’ in crime prevention interventions. As something potentially at the frontier of future work, this position involves a combination of skills including site and crime assessment, interpersonal communication, collaborative engagement, and horizon scanning.
Safety, efficacy, and clinical outcomes of transcatheter tricuspid valve replacement: One-year follow-up
Authors: Mao Yu , Li Lanlan , Liu Yang , Zhai Mengen , Ma Yanyan , Xu Chennian , Jin Ping , Yang Jian
Published: December 2022

Objective

The aim was to evaluate the safety and efficacy of TTVR in patients with severe TR at the 1-year follow-up.

Materials and methods

This project was a single-center, observational study. From September 2020 to May 2021, 15 patients with severe or extremely severe TR at high risk of traditional surgery were enrolled. All patients had preoperative imaging assessments to evaluate the tricuspid valve and the anatomy of the right heart. All patients were planned to treated with the LuX-Valve (Ningbo Jenscare Biotechnology, Ningbo, China). The LuX-Valve was implanted under the intraoperative guidance of TEE and X-ray fluoroscopy. Data were collected at baseline, before discharge, and at 30 days, 6 months, and 1 year postoperatively.

Results

The LuX-Valves were successfully implanted in all 15 patients. TR was significantly reduced to ≤ 2 +. One patient died on postoperative day 12 of a pulmonary infection that was considered unrelated to the procedures or the devices. The remaining 14 patients (100.0%) reached the primary end point. One patient (7.1%) was rehospitalized during 1-year follow-up because of device thrombosis. The number of patients who survived at 1 year with New York Heart Association (NYHA) functional class II was higher than that before TTVR (11/14 vs. 0/15, P = 9.11 × 10–4). Patients with peripheral edema and ascites decreased from 100.0 to 46.7% at baseline to 28.6% and 14.3% at 1 year (P = 1.57 × 10–3 and 2.53 × 10–2).

Conclusion

TTVR is associated with RV remodeling, increased cardiac output, and improvement in NYHA functional class. Using the LuX-Valve for TTVR to treat patients with severe TR is a feasible and relatively safe method with reliable clinical results. Further studies are needed to determine long-term outcomes.
Characteristics and outcomes of percutaneous coronary interventions in patients with spontaneous coronary artery dissection. A study from the administrative minimum data set of the Spanish National Health System
Authors: Alfonso Fernando , Fernández-Pérez Cristina , del Prado Náyade , García-Guimaraes Marcos , Bernal José Luis , Bastante Teresa , del Val David , García-Márquez María , Elola Javier
Published: December 2022

Background

Coronary revascularization in patients with spontaneous coronary artery dissection (SCAD) is challenging. Indications and results of percutaneous coronary interventions (PCI) in SCAD patients are not well established.

Aim

To assess indications and results of PCI in SCAD.

Methods

The minimum basic data set of the Spanish National Health System (years 2016−2019) was used to identify 804 episodes of acute myocardial infarction (AMI) and SCAD, with a crude in-hospital mortality rate of 3%. Of these, 368 (46.8%) patients were revascularized with PCI during admission whereas 436 (54.2%) were managed conservatively.

Results

Revascularization and in-hospital mortality rates both declined over the study period (p for trend both < 0.05). SCAD patients treated with PCI were older, more frequently male, and had higher frequency of diabetes, ST-segment elevation AMI and cardiogenic shock, compared to patients managed conservatively. The crude in-hospital mortality rate was higher in patients treated with PCI (4.9% vs. 1.4%; p = 0.004). However, after adjusting by propensity score (223 pairs) the in-hospital mortality rate was similar in the two groups (Adj OR: 1.21; 95%CI: 0.30−1.57; p = 0.76). Readmissions at 30-days were higher in patients managed conservatively (7.1 vs. 1.6%, p < 0.001) and this difference was maintained after propensity score adjustment (Adj average treatment effect: 2% vs. 12.2%; OR: 0.15; 95%CI: 0.04−0.45; p < 0.001).

Conclusion

Revascularization is frequently used in unselected patients with AMI and SCAD but its use is declining. Patients with SCAD treated with PCI have a higher in-hospital mortality but this appears to be explained by their adverse baseline clinical characteristics.
Multi-scale governance and data for sustainable development
Authors: Pastor-Escuredo David , Gardeazabal Andrea , Koo Jawoo , Imai Asuka , Treleaven Philip
Published: December 2022

Future societal systems will be characterized by heterogeneous human behaviors and data-driven collective action. Complexity will arise as a consequence of the 5th Industrial Revolution and 2nd Data Revolution possible, thanks to a new generation of digital systems and the Metaverse. These technologies will enable new computational methods to tackle inequality while preserving individual rights and self-development. In this context, we do not only need data innovation and computational science, but also new forms of digital policy and governance. The emerging fragility or robustness of the system will depend on how complexity and governance are developed. Through data, humanity has been able to study a number of multi-scale systems from biological to migratory. Multi-scale governance is the new paradigm that feeds the Data Revolution in a world that would be highly digitalized. In the social dimension, we will encounter meta-populations sharing economy and human values. In the temporal dimension, we still need to make all real-time response, evaluation, and mitigation systems a standard integrated system into policy and governance to build up a resilient digital society. Top-down governance is not sufficient to manage all the complexities and exploit all the data available. Coordinating top-down agencies with bottom-up digital platforms will be the design principle. Digital platforms have to be built on top of data innovation and implement Artificial Intelligence (AI)-driven systems to connect, compute, collaborate, and curate data to implement data-driven policy for sustainable development based on Collective Intelligence.
The crosstalk within the breast tumor microenvironment in type II diabetes: Implications for cancer disparities
Authors: Ennis Christina S. , Llevenes Pablo , Qiu Yuhan , Dries Ruben , Denis Gerald V.
Published: December 2022

Obesity-driven (type 2) diabetes (T2D), the most common metabolic disorder, both increases the incidence of all molecular subtypes of breast cancer and decreases survival in postmenopausal women. Despite this clear link, T2D and the associated dysfunction of diverse tissues is often not considered during the standard of care practices in oncology and, moreover, is treated as exclusion criteria for many emerging clinical trials. These guidelines have caused the biological mechanisms that associate T2D and breast cancer to be understudied. Recently, it has been illustrated that the breast tumor microenvironment (TME) composition and architecture, specifically the surrounding cellular and extracellular structures, dictate tumor progression and are directly relevant for clinical outcomes. In addition to the epithelial cancer cell fraction, the breast TME is predominantly made up of cancer-associated fibroblasts, adipocytes, and is often infiltrated by immune cells. During T2D, signal transduction among these cell types is aberrant, resulting in a dysfunctional breast TME that communicates with nearby cancer cells to promote oncogenic processes, cancer stem-like cell formation, pro-metastatic behavior and increase the risk of recurrence. As these cells are non-malignant, despite their signaling abnormalities, data concerning their function is never captured in DNA mutational databases, thus we have limited insight into mechanism from publicly available datasets. We suggest that abnormal adipocyte and immune cell exhaustion within the breast TME in patients with obesity and metabolic disease may elicit greater transcriptional plasticity and cellular heterogeneity within the expanding population of malignant epithelial cells, compared to the breast TME of a non-obese, metabolically normal patient. These challenges are particularly relevant to cancer disparities settings where the fraction of patients seen within the breast medical oncology practice also present with co-morbid obesity and metabolic disease. Within this review, we characterize the changes to the breast TME during T2D and raise urgent molecular, cellular and translational questions that warrant further study, considering the growing prevalence of T2D worldwide.
Workplace commute in Shanghai under post-pandemic rehabilitation: Health and fitness problems in planning and sustainability challenges
Authors: Shen Zhuya
Published: December 2022

The COVID-19 has changed people’s lifestyle from many aspects such as the way people commute and their attention to health and fitness, and environmental problems. This report is to understand how residents in Shanghai commute with difficulties and the environmental sustainability challenges and health issues in the post-pandemic rehabilitation background. Taking educational institution in Shanghai as example, this study applied big data techniques with kernel density, Ripley’s K(d) function and 2SFCA analysis to identify the spatial characteristics and accessibility of different institution types under different travel modes such as walking. The results show that the distribution is extremely uneven in Shanghai, area with extreme concentration is observed. In case of educational workplace, although the proportion of street-town with moderate or higher accessibility reached 74.34%, such proportion is only 41.01% for walking mode. Current planning has skewed commuting around educational sites towards more carbon-intensive travel patterns and not conducive for keeping fit and health. Besides, households located in the districts of Chongming, Qingpu and Jinshan commute much longer than those in other regions. Long commute time and less exercise may lead to the wider spread of disease and it’s harmful to residents’ health and sustainable living. In summary, the findings of this paper regarding commuting to educational sites provide a clearer understanding of the health and sustainability challenges for policymakers.
Spatial differences, distributional dynamics, and driving factors of green total factor productivity in China
Authors: Zhao Peiyang , Wu Haiyan , Lu Zhiguo , Kou Jiali , Du Jun
Published: December 2022

Graphical Abstract

Flow chart of China GTFP.
Fine-scale assessment of Chlorella syrup as a nutritional supplement for honey bee colonies
Authors: Dostálková Silvie , Kodrík Dalibor , Simone-Finstrom Michael , Petřivalský Marek , Danihlík Jiří
Published: December 2022

Habitat loss, climate change, and global agriculture have a non-negligible effect on the reduced abundance and diversity of floral resources. Malnutrition and nutritional stress are consequences of the combination of these factors with considerable impact on honey bee health and colony losses. The solution to inadequate natural sources for beekeeping is the additional feeding of honey bee colonies with food supplements. The algae Chlorella is a natural food source, with a nutrient profile similar to natural pollen, thus it has promising application in beekeeping. We evaluated Chlorella vulgaris syrup as a dietary supplement in the view of the oxidative stress that may be caused by long term administration to the colonies. Consuming Chlorella syrup did not influence the activity of digestive enzymes of summer honey bee workers, however, lipase activity insignificantly increased. After Chlorella application to colonies, we also observed insignificantly higher gene expression of antioxidant enzymes catalase and superoxid dismutase1 in adult workers; however, in larvae the expression of those genes was not affected. Surprisingly, the gene expression did not correspond with enzyme activity in adult bee abdomens. In Chlorella fed colonies, we recorded a higher concentration of vitellogenin, which plays multiple roles in honey bee physiology, i.e., antioxidant, storage protein, or immunity-related functions. Our new findings brought evidence that Chlorella did not negatively affect the digestion or oxidative balance of honey bees, thus its application as a pollen supplement can be fully recommended for maintaining the health of honey bee colonies during periods of dearth.
Centennial records of Polycyclic aromatic hydrocarbons and black carbon in Altay Mountains peatlands, Xinjiang, China
Authors: Luo Nana , Wen Bolong , Bao Kunshan , Yu Rui , Sun Jing , Li Xiujun , Liu Xingtu
Published: December 2022

Black carbon (BC) is an important inert carbon component in the cycling process of surface carbon. Polycyclic aromatic hydrocarbons (PAHs) are a kind of thick cyclic organic compounds with carcinogenic, teratogenic, and mutagenic effects. The incomplete burning process of biomass and carbolic fuel is the important source of their co-occurrence. This study collected a 60-cm peat core from the Jiadengyu (JDY), Altay Mountain. The core was dated using the 210Pb and 137Cs methods. The results showed BC, total organic carbon, and PAHs of the JDY peat core to be 1.14–72.6 mg g−1, 17.09–47.2%, and 260.58–1,610.77 ng·g−1, respectively. δ13CBC was between −31.5 and − 29.4‰ (mean of −30.56‰). The results of scanning electron microscopy (SEM) indicated irregular or lumpy peat BC particles, retaining a plant fiber structure. δ13CBC, ratios of PAHs, and the SEM revealed that the BC to be the dominant source of biomass combustion in the peatland. BC showed an increasing trend between 1950 and 1980, after which it decreased. The discrepancy between the change in BC and δ13CBC from the national pattern of BC emission likely reflects the effect of local agricultural exploration, and thus an increase in crop burning.
Retrospective analysis of the sex chromosomal copy number variations in 186 fetuses using single nucleotide polymorphism arrays
Authors: Wang Haiwei , Liang Bin , Wang Yan , Huang Hailong , Lin Na , Xu Liangpu
Published: December 2022

Sex chromosomal abnormalities are associated with multiple defects. However, the types of sex chromosomal abnormalities during pregnancy in Fujian Province, China, are not recorded. In this retrospective analysis, we showed the sex chromosomal abnormalities of 186 fetuses, including 162 cases of X chromosomal abnormalities and 22 cases of Y chromosomal abnormalities in Fujian Province. We detected 73 cases of Turner syndrome, 24 cases of triple X syndrome, 37 cases of Klinefelter syndrome, and 14 cases of XYY syndrome. It was observed that 67.3% fetuses with classic Turner syndrome had their growth arrested. Moreover, we found 21 cases of mosaic Turner syndrome, 3 cases of mosaic Triple X syndrome, 2 cases of mosaic Klinefelter syndrome, and 1 case of mosaic XYY syndrome. Furthermore, 37 cases of large scales of sex chromosomal deletions/duplications were detected, including 30 cases of X chromosomal deletions/duplications and 7 cases of Y chromosomal deletions/duplications. Parent-of-origins of five cases of sex chromosomal deletions/duplications were determined. One case was with de novo X chromosomal variations, while the sex chromosomal deletions/duplications in other four cases were inherited from their parents. Overall, our results presented a detailed manifestation of sex chromosomal abnormalities of 186 fetuses in Fujian Province and suggested the important roles of single nucleotide polymorphism (SNP) array analysis in the prenatal diagnosis of sex chromosomal abnormalities. Also, determining the parent-of-origins of the deletions/duplications was critical for the prenatal diagnosis of sex chromosomal abnormalities.
An update on the genetics of alcoholic liver disease
Authors: Vishnubhotla Ravikanth , Kulkarni Anand V. , Sharma Mithun , Rao Padaki Nagaraja , Reddy Duvvur Nageshwar
Published: December 2022

Worldwide, an estimated 2 billion individuals consume alcohol, which contributes to short-term or long-term consequences on health and social life. Alcohol is the cause of approximately 1.8 million deaths per year, representing 3.2% of all deaths worldwide. Of the 2 billion individuals who consume alcohol, more than 75 million are diagnosed with alcohol-use disorder (AUD) and are at an enhanced risk of developing alcoholic liver disease (ALD). However, not all individuals who consume alcohol develop liver disease suggesting the intricate interactions of host genetics with the environment in the precipitation of the phenotype. With advances in genomic technologies, it is now possible to sequence clinically relevant genomic loci associated with a phenotype with precision and faster turnaround times. Genomic data in the form of variants may be used to predict susceptibility to a phenotype in an unaffected individual or may assist the clinician in predicting the outcomes after the onset of the disease. Both of these are crucial as the former would aid in reducing the future burden of the disease, and the latter would help identify and treat individuals at risk of severe liver disease. In the current review, we summarize the pathogenic mechanisms of ALD and discuss the variants identified to date that may aid in predicting alcohol dependence and the development of cirrhosis in individuals with AUD.
Junctional adhesion molecule-A is dispensable for myeloid cell recruitment and diversification in the tumor microenvironment
Authors: Kiss Máté , Lebegge Els , Murgaski Aleksandar , Van Damme Helena , Kancheva Daliya , Brughmans Jan , Scheyltjens Isabelle , Talebi Ali , Awad Robin Maximilian , Elkrim Yvon , Bardet Pauline M. R. , Arnouk Sana M. , Goyvaerts Cleo , Swinnen Johan , Nana Frank Aboubakar , Van Ginderachter Jo A. , Laoui Damya
Published: December 2022

Junctional adhesion molecule-A (JAM-A), expressed on the surface of myeloid cells, is required for extravasation at sites of inflammation and may also modulate myeloid cell activation. Infiltration of myeloid cells is a common feature of tumors that drives disease progression, but the function of JAM-A in this phenomenon and its impact on tumor-infiltrating myeloid cells is little understood. Here we show that systemic cancer-associated inflammation in mice enhanced JAM-A expression selectively on circulating monocytes in an IL1β-dependent manner. Using myeloid-specific JAM-A-deficient mice, we found that JAM-A was dispensable for recruitment of monocytes and other myeloid cells to tumors, in contrast to its reported role in inflammation. Single-cell RNA sequencing revealed that loss of JAM-A did not influence the transcriptional reprogramming of myeloid cells in the tumor microenvironment. Overall, our results support the notion that cancer-associated inflammation can modulate the phenotype of circulating immune cells, and we demonstrate that tumors can bypass the requirement of JAM-A for myeloid cell recruitment and reprogramming.
Rapid response in relapsed follicular lymphoma with massive chylous ascites to anti-CD19 CAR T therapy using Piggy Bac: A case report
Authors: Zhang Yan , Lin Zhicai , Zhang Faliang , Chen Xiuxiu , Yang Yaping , Fu Xin , Li Zhong , Sun Yan , Qian Qijun
Published: December 2022

CD19-directed chimeric antigen receptor (CAR) T cell therapy has been shown to achieve a considerably durable response in patients with refractory or relapsed B cell non-Hodgkin lymphomas, as seen from the results of Zuma-1, Zuma-5, and other clinical trials. Most of these CARs were generated by lentivirus or reverse adenovirus. It is rare to see CARs using non-viral vectors, such as Piggy Bac (pb), in treating lymphoma patients with active diseases. Generally, patients with a high tumor burden tend to have a higher rate of severe cytokine release syndrome (CRS) or neurological events as reported in the literature. Patients with symptomatic pleural effusions are excluded from the Zuma-1 trial because of the risk of severe CRS. We report here that a patient with relapsed follicular lymphoma with bulky disease and massive chylous ascites failed several lines of chemotherapy. After infusion of the CD19-directed pbCAR-T cells at 6 × 106 cells/kg, the patient had a rapid response and achieved a nearly complete metabolic remission on day 28. There was only grade 1 CRS, and no neurotoxicity occurred. The CAR-T cells reached a peak level on day 14 and spread into the ascites and expanded for 3 months. This might be the first case reported for pbCAR-T cells to treat relapsed follicular lymphoma directly. The long-term efficacy will be observed, and more patients be tested in the future.

Clinical Trial Registration

https://ClinicalTrials.gov, identifier NCT05472610.
STXBP3 and GOT2 predict immunological activity in acute allograft rejection
Authors: Yao Qinfan , Wang Cuili , Wang Yucheng , Xiang Wenyu , Chen Yin , Zhou Qin , Chen Jianghua , Jiang Hong , Chen Dajin
Published: December 2022

Background

Acute allograft rejection (AR) following renal transplantation contributes to chronic rejection and allograft dysfunction. The current diagnosis of AR remains dependent on renal allograft biopsy which cannot immediately detect renal allograft injury in the presence of AR. In this study, sensitive biomarkers for AR diagnosis were investigated and developed to protect renal function.

Methods

We analyzed pre- and postoperative data from five databases combined with our own data to identify the key differently expressed genes (DEGs). Furthermore, we performed a bioinformatics analysis to determine the immune characteristics of DEGs. The expression of key DEGs was further confirmed using the real-time quantitative PCR (RT-qPCR), enzyme-linked immunosorbent assay (ELISA), and immunohistochemical (IHC) staining in patients with AR. ROC curves analysis was used to estimate the performance of key DEGs in the early diagnosis of AR.

Results

We identified glutamic-oxaloacetic transaminase 2 (GOT2) and syntaxin binding protein 3 (STXBP3) as key DEGs. The higher expression of STXBP3 and GOT2 in patients with AR was confirmed using RT-qPCR, ELISA, and IHC staining. ROC curve analysis also showed favorable values of STXBP3 and GOT2 for the diagnosis of early stage AR.

Conclusions

STXBP3 and GOT2 could reflect the immunological status of patients with AR and have strong potential for the diagnosis of early-stage AR.
Global research landscape and trends of lung cancer immunotherapy: A bibliometric analysis
Authors: Liu Yanhao , Cheng Xu , Han Xiaona , Cheng Xi , Jiang Shu , Lin Yaru , Zhang Zhen , Lu Linlin , Qu Baozhen , Chen Yuxian , Zhang Xiaotao
Published: December 2022

​Background

Immunotherapy for lung cancer has been a hot research area for years. This bibliometric analysis aims to present the research trends on lung cancer immunotherapy.

Method

On 1 July, 2022, the authors identified 2,941 papers on lung cancer immunotherapy by the Web of Science and extracted their general information and the total number of citations. A bibliometric analysis was carried out to present the research landscape, demonstrate the research trends, and determine the most cited papers (top papers) as well as major journals on lung cancer immunotherapy. After that, recent research hotspots were analyzed based on the latest publications in major journals.

Results

These 2,941 papers were cited a total of 122,467 times. “Nivolumab vs. docetaxel in advanced non–squamous non–small–cell lung cancer” published in 2015 by Borghaei H et al. was the most cited paper (5,854 citations). Among the journals, New England Journal of Medicine was most influential. Corresponding authors represented China took part in most articles (904) and papers with corresponding authors from the USA were most cited (139.46 citations per paper). Since 2015, anti–PD–(L)1 has become the hottest research area.

Conclusions

This bibliometric analysis comprehensively and quantitatively presents the research trends and hotspots based on thousands of publications, and further suggests future research directions. Moreover, the results can benefit researchers to select journals and find potential collaborators. This study can help researchers get a comprehensive impression of the research landscape, historical development, and recent hotspots in lung cancer immunotherapy and provide inspiration for further research.