bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPARATIVE ANALYSIS OF GROUND-BASED AIR DEFENCE SYSTEM CAPABILITIES: JAMMING AND MANEUVERING
Authors:   Academia Fortelor Aeriene ", Sandru Vasile-Ioan ,   Henri Coanda", Radulescu Marius ,   S. Electromecanica Ploieşti SA
Published: January 2023

Nowadays, the vertical component of war, continuously subjected to in-depth analyses concerning its development and represented by two different system types – Aerial and Air Defence – is (and will be in the future) the decisive element of victory. Due to the assiduous development of this component, the physiognomy of war will be reshaped, with a higher weight on its vertical dimension, as opposed to the military actions conducted in the other traditional environments: terrestrial or maritime.
EFFECTS OF FATIGUE ON AERONAUTICAL PERFORMANCE
Authors:   Academia Fortelor Aeriene ", BĂLTEANU Albert ,   Henri Coanda", CRĂCIUN George
Published: January 2023

Events occurring in aviation affect the entire activity of a company. The contribution to the occurrence of an event is both routine and fatigue that can have negative preponderant effects. Identifying the factors favoring the occurrence of an event brings a progress in the development of programs to maximize flight safety. The study of routine and fatigue factors raises the level of importance and awareness on aviation events. Each member of the company must actively participate in the compliance of working procedures to increase the degree of safety at work. This level can only be reached when we establish and maintain strict rules, eliminate chaos and stress, minimize the pressure of tasks to create an environment proper to development. The study addresses all aeronautical personnel to increase the understanding of the effects of fatigue and how they contribute to the rate of occurrence of events.
HANDLING DYNAMIC NONLINEARITIES IN UAV AUTOMATIC FLIGHT CONTROL SYSTEMS
Authors:   Óbuda University, Budapest, Hungary, SZABOLCSI Róbert
Published: January 2023

The linear or the nonlinear feature of systems being modelled or designed is a core property we should be familiar with before taking up any system design or analysis-related task. The dynamic model-based closed loop control design is widely used in control engineering when dynamic or static nonlinearities are considered to be present in the closed loop control system. This paper addresses both dynamical and static nonlinearities modelled and handled in the closed loop control system
THE CHILD WITH SPECIAL EDUCATIONAL NEEDS (SEN): A HISTORY OF SOCIAL PERCEPTION
Authors:   Faculty of Psychology and Educational Sciences, Bucharest, Romania, PETCU (RADU) Anamaria
Published: January 2023

The complexity of situations in the educational sphere generated by the presence of people at risk, in vulnerable situations is currently one of the priorities of governments worldwide. Historical periods show us that their social perception and acceptance was not at all favorable, on the contrary, attitudes ranged from hostility to extermination programs. History shows us that the separation of people with disabilities from others was determined by the fear of contamination and also by the desire to escape responsibility regarding those who were a burden to society and considered useless.
HUMAN RESOURCES MANAGEMENT AFTER THE COVID-19 PANDEMIC: BACK TO 2019 OR AHEAD TOWARDS A NEW MANAGEMENT OF HUMAN RESOURCES?
Authors:   “Valahia” University, Târgovişte, Romania, FLOROIU (MIHAI) Florina , LUCHIAN Andrei-Mihai ,   Special Telecommunications Service, Bucharest, Romania
Published: January 2023

During the COVID-19 pandemic the management of human resources changed dramatically, especially since digitalization grew overwhelmingly overnight and multi-national companies were forced to close office buildings and work remotely. In other words, the IT industry went sky high and the demand for IT specialists increased as everything became automatized. Working from home has increased the demand for specialists and software in every branch of any company and even after COVID-19, people find it difficult to readjust to the lifestyle they were accustomed to before 2020, due to the fact that in the meantime, they have learned to use software that can help them do the same thing from home, but faster and in a more precise way than previous software versions would have allowed. Thus, the hybrid working system is more viable nowadays and even reducing the number of working days per week may soon become possible.
TEVFİK FİKRET ŞİİRİNDE AYDINLANMANIN VOKABÜLERİ
Authors: GÜZEL Ekrem
Published: January 2023

Türk edebiyatında, Tanzimat dönemiyle birlikte Batılılaşma, modernleşme ve Aydınlanmanın açık etkileri görülmeye başlar. Aralarında yazar ve şairlerin de bulunduğu aydınların bir kısmı Batılı değerleri ve modernleşme biçimini temel ilke olarak benimserler. Bu ilkeleri de metinlerinde bir konu olarak işlerler. Bunlardan biri olan Tevfik Fikret, bir şair olmanın yanında bir aydın olarak tanınmıştır. Modern Türkiye’de Batıcılığı ve modernleşmeyi savunanların sıklıkla referansta bulundukları bir şair olan Fikret, özellikle son dönem şiirlerinde aydınlanma düşüncesini benimseyen bir tutum sergilemiştir.
Bu makalede Tevfik Fikret’in şiirlerinde görülen Aydınlanma düşüncesi üzerinde durulmuştur. Onun son dönem şiirlerinde Aydınlanmanın temel ilkelerini benimseyen ve anlatan bir tutum içerisinde olduğu ileri sürülmüştür. Aydınlanmanın temel unsurları ve ilkeleri olan akla ve bilime inanma, ilerleme fikri, hümanizm, evrensellik, özgürlük, vicdan ve sekülerlik gibi kavramların Fikret’in şiirinde nasıl göründüğü ortaya konulmuştur. Şairin geleceği esas alarak gençlere hitap ettiğine; yine bu bağlamda tarihi, dini ve geleneği ne şekilde eleştirdiğine değinilmiştir. Böylece Aydınlanma ve modernleşmenin Türk edebiyatındaki önemli bir şairin metinlerine yansımaları ortaya konulmuştur.
NAZÎRÂ’NIN MANZUM ÇINNÂME VE SEĞİRNÂMESİ
Authors: KAPLAN Yunus
Published: January 2023

İnsanoğlu tarih boyunca gaybı ve gelecekte yaşanacak olayları hep merak etmiş, bu merak duygusu da onu her daim çeşitli arayışlara sevk etmiştir. Bu arayışların bir neticesi olarak daha çok gelecek üzerine yapılan tahminlere dayanan gaybî ilim türleri doğmuştur. Kulak çınlamasının esas alındığı çınnâmeler ve vücudun çeşitli organlarının seğirmesi üzerine tecrübe edilmesi muhtemel hadiseler üzerine yapılan tahminlerden oluşan seğirnâmeler bu ilim dalları arasında yer alır. Sayısı birkaç örnekle sınırlı olan çınnâmelerin aksine elde kahir ekseri mensur olan çok sayıda seğirnâme metni bulunmaktadır. Farklı zamanlarda kaleme alınmış olan ve hemen hemen hepsinin müellifi meçhul olan mensur seğirnâmeler dışında az da olsa manzum şekle sahip olanları da mevcuttur.
Edebî geleneğimizde şimdiye kadar manzum çınnâme örneğine rastlanılmamışsa da 19. yüzyılda yaşadığı tahmin edilen Sevâdî’ye ait manzum bir seğirnâmenin varlığı bilinmektedir. Sevâdî dışında manzum seğirnâme kaleme alan şairlerden biri de Nazîrâ’dır. Şair, bu manzume dışında aynı zamanda manzum çınnâme de yazmıştır. Mesnevi nazım şekline sahip olan ve aruzun “mefâʻîlün mefâʻîlün feʻûlün” kalıbıyla tanzim edilen her iki manzumeden Çınnâme on beyit, Seğirnâme ise 92 beyitten müteşekkildir. Nazım şekli ve vezin dışında sade bir dile sahip olmaları bu manzumelerin ortak özelliklerinden bir diğeridir.
Bu çalışmada türlerinin nadir örneklerinden olan Nazîrâ’nın manzum Çınnâme ve Seğirnâme’sinin şekil ve muhteva özellikleri üzerinde durulduktan sonra çeviri yazılı metinleri araştırmacıların dikkatlerine sunulmuştur.
LITHUANIAN GASTRONOMIC TOURISM POTENTIAL: OPPORTUNITIES AND PERSPECTIVES
Authors: Baltrūnaitė Danguolė , Jakštienė Danutė , Voišnis Jadvyga
Published: January 2023

Purpose – the aim of this paper is to analyze the gastronomic tourism trends in the world and in Lithuania, to determine the opportunities and the potential of gastronomic tourism in Lithuania and to provide recommendations for its development. Design – the theoretical part gives the understanding of gastronomic tourism in the world and its potential in Lithuania. The research gives an understanding of gastronomic tourism situation in Lithuania. Methodology – the research was done using analysis of scientific literature, secondary data analysis method of analysis and synthesis, quantitative research. The quantitative method used in this paper is a survey conducted among the local travelers. The results of the research were statistically processed using the Excel. Approach - gastronomic tourism is becoming an increasingly popular area of tourism, generating billions in revenue for businesses worldwide. According to the Global Report on Food Tourism, 79 percent travelers travel itinerary consists of a pre-analyzed calendar of gastronomic events and local cuisine, one in three travelers consider national cuisine to be a motivating travel choice and spends about 30 percent on food of total travel expenses. Findings – in Lithuania, gastronomic travel is still a relatively new niche in tourism. In recent years, this area of tourism has attracted considerable interest from foreign tourists and local travelers, however, the Covid 19 pandemic halted travel. Due to the tense situation in Europe, Lithuania still does not receive a larger number of tourists from foreign countries. Hospitality businesses use variety of means to engage, attract, and encourage local people to travel. Gastronomic tourism is one of such measures, as Lithuania can offer travelers quality local food, interesting national dishes with deep traditions, various food festivals and events. Originality of the research – the article analyzes results of research, discusses ways of attracting local tourists introducing more variety in gastronomic tourism. Practical implications are based on research findings and could be used by local travel agencies creating new gastronomic tourism products.
Remzi Kılıç, Osmanlı Yönetiminde Irak ve Suriye [Tarihî Coğrafyası - XIX. Yüzyılda İdarî Yapısı], İdeal Kültür Yayınları, İstanbul 2011
Authors: DERİ Mehmet
Published: January 2023

İnsanlık tarihi boyunca yaşanan ve kayıt altına alınan pek çok olgu bugün Ortadoğu ve civarı diye tesmiye edilen coğrafyada gerçekleşmiştir. Bugünkü Mısır’dan Filistin’e, Arabistan’dan Basra Körfezi’ne, oradan da Mezopotamya (Irak ve Suriye başta olmak üzere) üzerinden Anadolu’ya kadar uzanan bu verimli topraklar, insanlığın ilk yerleşim yerlerindendir.
Genel olarak Ortadoğu; yerleşik medeniyetlerin kurulduğu, hayvancılığın başladığı, tarımın öne çıktığı, astronomik hesaplar ve sulama kanalları ile sistemleştiği, ilk devletlerin ve savaşçı imparatorlukların kurulduğu, yazının icat edilip kullanıldığı, ilk kanunların yazıldığı, ilk antlaşmaların imzalandığı, ticaretin ve ekonominin geliştiği, tek tanrılı dinlerin ortaya çıktığı ve ilk inanç yapılarının yükseldiği bir alan olmuştur.
Tanıtımı yapılan çalışmada; konular özlü bir şekilde ele alınmış, alanında konuyla ilgili temel kaynaklar kullanılarak zengin bir akademik literatürle hazırlanmış; Irak ve Suriye toprakları XIX. yüzyılın sonlarındaki idarî taksimatı göz önünde bulundurularak ‘Tarihî Coğrafya’ açısından akademik bir perspektiften incelenmiştir.
Determinants of Audit Quality in Companies That Conduct Initial Public Offerings
Authors: Tania Dinda , Tarmizi M. Irfan , Adrian Muhammad
Published: January 2023

This research aims to investigate factors that affect quality control, including audit period, auditor reputation, accounting firm size, and audit fees. The population of this study consisted of 54 companies that participated in the Initial Public Offering (IPO) and were listed on the Indonesia Stock Exchange (IDX) in 2021. The sample was taken using the purposive sampling method to obtain a sample of 42 companies. This study uses quantitative data analysis techniques. SPSS version 20 is used for statistical analysis in data analysis. From the results of this study, audit tenure, Public Accounting Firm size, and audit fees do not affect audit quality; partial research confirms that auditor reputation significantly impacts audit quality. The results of this study can be used as a reference for auditors to improve audit quality for companies conducting IPO.
Continuous Quality Improvement of People's Salt Production to Achieve SNI Salt Through the Process of Recrystallization of Salt Quality III
Authors:   Universitas Trunojoyo Madura, Winarso Kukuh , Akhmad Sabarudin , Hidayat Rachmad , Prananta Arie Wahyu , Abidin Zainal
Published: January 2023

Salt is a strategic commodity as a consumption requirement that contains several substances, including the content of NaCl. Salt is produced with three types of qualities which include salt quality one, salt quality two, and salt quality three. Salt quality three is salt that has the lowest quality such as the color of salt that is dull and not consumed. These three quality salts are usually used for agriculture and agriculture. Improvement of salt quality is done by doing the process of recrystallization which then the results of the recrystallization process are measured by looking at changes in NaCl content and salt color. This research was conducted in West Pademawu, Pademawu District, Pamekasan Regency as a place to recrystallize salt and Village Unit Cooperatives "Karya Sakti" Montok Larangan District Pamekasan Regency as a place to conduct laboratory tests on the content of NaCl. The analysis used to determine the improvement in salt quality is the content of NaCl and the color of salt. The research design used is a complete random design (RAL) factorial. The use of the factorial RAL method has three factors, namely, the first factor is the composition of the solution with two levels, namely 15% and 20%. The second factor is the temperature with two levels is 110oC and 120oC. The third factor is the length of boiling with two levels, namely one hour and two hours. Data is analyzed by conducting Analysis Of Variance (ANOVA) tests and further tests.. The results of the analysis showed that no significant influence was influenced by the interaction factors between the composition of the solution, temperature, and length of boiling of NaCl and salt color. But from the results of the process of recrystallization of NaCl salt content and salt color experienced an increase that originally had NaCl content of 94,59% to 98%. Similarly, the color of salt has increased which was originally at the 4th level then increased to level 2. With the process of recrystallization of salt, salt that was original of three qualities increased to two qualities.
Optimization of Madura Corn Supply Chain Network in Bangkalan District
Authors:   Universitas Trunojoyo Madura, Akhmad Sabarudin , Winarso Kukuh , Hidayat Rachmad , Prananta Arie Wahyu , Abidin Zainal
Published: January 2023

The main problem faced to develop the Madura corn industry that can compete in the global market is that corn research is still fragmented not fully integrated. For example, research only focuses on Madura corn seedlings, corn cultivation methods, corn processing, corn derivative products. All corn research is done alone has not been fully integrated. Whereas to make a Madura corn industry that can compete in the global market, integrated studies ranging from superior seed supply, guaranteed fertilizer supply, land to grow well-maintained corn, adequate transportation tools, transportation lines, production processes, warehouses, retail to the end-user of corn. The most likely approach with supply chain models and interval models. The point obtained is in accordance with the number of existing farmer groups, namely 534 groups of farmers with the number of representative warehouses as many as 7 warehouses and the representative point of farmers groups by grouping a number of 96 groups of farmers. The representative warehouse placement area based on the selected coordinate point is the 1st Warehouse with a coordinate point of -7.061796 LS, 113.433065 BT is at Glugur 1,. Palengaan Laok, Palengaan District, 2nd Warehouse with coordinate point -7.090207 LS, 113.557724 BT is at Kadur, Kadur District, 3rd Warehouse with coordinate point -7.143604 LS, 113.427529 BT is at Tengah, Talangoh, Proppo District, 4th Warehouse with coordinate point -7.182906 LS, 113.498554 BT is at Kebon, Sumedagan, Pademawu District, 5th Warehouse with coordinate point -6.946236 LS, 113.506879 BT is at Camplok Barat, West Lesong, Batumarmar District, 6th Warehouse with coordinate point -6.925745 LS, 113.535418 BT is at Tengah, Tagengser Dajah, Pasean District, 7th Warehouse with coordinate point -6.919440 LS, 113.606958 BT is at Kolla, West Dempo, Pasean District. Total transportation cost = Rp 30,300,000 + Rp 118,657 = Rp 30,418,675,- Transportation rate = Rp 30,418,675 / 151014 kg = Rp 201,- / kg / km.
Level of self-care practices and associated factors among Hypertensive Patients in Addis Ababa, Ethiopia
Authors: Sahile Addisu Tadesse , Nurhussien Hayat Abdulkadir
Published: January 2023

Objectives: The study assessed the level of self-care practice and its predictors among hypertensive patients in the health centers of Bole Sub-city, Addis Ababa, Ethiopia.
Methods: A multi-Center-based cross-sectional study that employed 370 hypertensive participants at the conveniently selected Health Centers in Bole Sub-City; conducted from August 01-30, 2020. The researchers selected the participants based on a simple random sampling method after obtained with a written informed consent and applying a pre-tested interviewer-administered questionnaire for data collection. All the statistical analyses were done using SPSS 22.0 software. Binary logistics regression used to determine the presence and strength of association; with its respective 95%CI and p-value, less than 5% used as a significant level.
Results: The overall level of good self-care practice among hypertensive patients was 53.0 %( 95%CI: 47.2%-58.8%) whereas 61.4%, 63.8%, 92.7%, 82.7%, and 18% of the study participants were adherent to medication, good weight management, non-smokers, alcohol abstainers and physical activity consecutively.
Being illiterate had 2.347 and 2.084 times higher odds of having had good self-care practice compared to secondary school and diploma or above consecutively. Being a merchant, civil, and retired were associated with good self-care practice than being unemployed.
Conclusion and Recommendation: A lower level of self-care practice was observed. Educational level and occupation were factors identified for self-care practice. The policymakers, healthcare workers, and researchers were recommended to work on the identified factors of self-care practice of hypertensive participants in the study settings.
Paleo–climatic and paleo–environment implication of clay mineral across Upper Cretaceous­–Lower Eocene deposits from Gafsa Basin
Authors: Majid Abdel
Published: January 2023

An integrated study of clay paragenesis has been conducted in the Gafsa Basin, southern Tunisia, during the Late Cretaceous–Lower Eocene. Six lithostratigraphic sections were logged in the Tamerza, Oued Thelja, Ong, and Chamsi. The Upper Maastrichtian Haria Formation is dominated by smectite, indicating a semi-arid climate with distinct seasons. A colder and drier climate, favoring physical alteration, is observed in the first Paleogene deposits. Danian deposits, show a decrease in smectite in favor of illite and kaolinite, indicating a period of intensified detritus under a hot and humid climate with a contrasting season. The abundance of smectite and the low percentages of kaolinite in the Thelja (Thanetian) Formation suggest a warm and arid climate. The late Thanetian–early Eocene deposits were influenced by a warm and seasonal climate, or probably, they were an alternation between dry and humid seasons and warm climatic conditions in the Lower Eocene corresponding to the Late Paleocene–early Eocene deposits outlining the Paleocene–Eocene Thermal Maximum (PETM). The consequence of this warm climate is sea level rise, which corresponds to the Paleocene– Eocene transgression.
Parents' awareness of the conscious use of applications on smart devices: A scale development study
Authors: Öztürk Gülcan , Şahin Feyza
Published: January 2023

Children inevitably start using smart devices from the first year of their lives. Parents should have knowledge and awareness of the conscious use of applications on smart devices. For this reason, a scale to measure parents’ knowledge and awareness of the conscious use of applications on smart devices has become necessary. Due to this necessity, we want to conduct this study. The research’s problem was how parents’ knowledge and awareness of the conscious use of applications on smart devices could be measured using a valid and reliable scale. We conducted the research in an exploratory sequential design with two stages one of the mixed methods research. We collected and analyzed qualitative data from 33 parents in the first stage, and we collected quantitative data from 602 parents and performed a quantitative analysis to evaluate the first stage’s results in the second stage. After reviewing the literature, we concluded that the scale’s dimensions as a theoretical model were (1) application, (2) benefit, (3) restriction, and (4) worry. We decided on the scale’s items according to the theoretical model after analyzing the parents’ opinions and obtaining experts’ evaluations for the content validity of the scale items. We demonstrated that the theoretical model was supported by the analyses we performed using the data we collected. We learned how a valid and reliable scale could be used to measure the parents’ knowledge and awareness of the conscious use of applications on smart devices, including current and future computer systems. The scale we developed had more specific dimensions compared to the scales in the literature about digital parenting.
Reporting Quality of Randomized Controlled Trials Evaluating Non- Vitamin K Oral Anticoagulants in Atrial Fibrillation：A systematic review
Authors: Yang YueGuang , Han YuBo , Zou GuoLiang , Sui YanBo , Jin Juan , Liu Li
Published: January 2023

Background: Randomized controlled trials (RCTs) are subject to bias if they lack methodological quality. Furthermore, optimal and transparent reporting of RCT ﬁndings aids their critical appraisal and interpretation. This study aimed to comprehensively evaluate the report quality of RCTs of non-vitamin K oral anticoagulants (NOACs) for the treatment of atrial fibrillation (AF) and to analyze the factors influencing the quality.
Methods: By searching PubMed, Embase, Web of Science, and Cochrane Library databases RCTs published from inception to 2022 evaluating the efficacy of NOACs on AF were collected. By using the 2010 Consolidated Standards for Reporting Tests (CONSORT) statement, the overall quality of each report was assessed.
Results: Sixty-twoRCTs were retrieved in this study. The median of overall quality score in 2010 was 14 (range: 8.5-20). The extent of compliance with the Consolidated Standards of Reporting Trials reporting guideline differed substantially across items: 9 items were reported adequately (more than 90%), and 3 were reported adequately in less than 10% of trials. Multivariate linear regression analysis showed that the higher reporting scores were associated with higher journal impact factor (P = 0.02), international collaboration (P < 0.01), and Sources of trial funding (P = 0.04).
Conclusions: Although a large number of randomized controlled trials of NOACs for the treatment of AFwere published after the CONTORT statement in 2010, the overall quality is still not satisfactory, thus weakening their potential utility and may mislead clinical decisions. This survey provides the first hint for researchers conducting trials of NOACs for AF to improve the quality of reports and to actively apply the CONSORT statement.
Bone marrow mesenchymal stem cell exosomes attenuate neuroinflammation after diabetic intracerebral hemorrhage via miR-129-5p/HMGB1
Authors: wang yueying , li ke , zhu hong , liu zhiyi , wang jiajun , hua wei , liu qi , sun yulan , zhang qianqian , song yuejia , qi jiping
Published: January 2023

Background
In this study, we investigated whether mesenchymal stem cell (MSC)-derived exosomes (Exos) could regulate hyperglycemia-induced neuroinflammation by transferring microRNA-129-5p (miR-129-5p).
Methods
Bone marrow-derived MSC (BMSC)-Exos were isolated from media BMSCs from mice. This was followed by transfection with miR-129-5p. BMSC-Exos or miR-129-5p-overexpressing BMSC-Exos were intravitreally injected into diabetic mice with intracerebral hemorrhage (DM/ICH) for in vivo analyses and were cocultured with high glucose-affected BV2 cells for in vitro analyses. RT-PCR and western blotting were conducted to assess the levels of some inflammation factors, such as high-mobility group box 1 (HMGB1), interleukin (IL)-6, IL-1β, toll-like receptor 4 (TLR4), and tumor necrosis factor α (TNFα).
Results
Our results indicate that hyperglycemia considerably increased inflammation in ICH mice or in BV2 cells exposed to high glucose with hemin and increased the expression levels of hmgb1 and its downstream inflammatory factors. BMSC-Exos administration could effectively reverse this reaction. Compared with administration of BMSC-Exos, administration of miR-129-5p-overexpressing BMSC-Exos more effectively suppressed the HMGB1 signaling pathway and suppressed inflammation both in vivo and in vitro. We also observed an improvement in cerebral hematoma and cerebral edema in DM/ICH mice after administration of the miR-129-5p mimic, which reduced the permeability of the blood–brain barrier.
Conclusions
We demonstrated that BMSC-Exos can reduce the inflammatory response after DM/ICH, thereby improving the neurological function of the brain, and we demonstrate that their effect is achieved through the miR-129-5p/HMGB1/TLR4 regulatory axis. At present, the mechanism by which exosomes from bone marrow mesenchymal stem cells regulate neuroinflammation after diabetic cerebral hemorrhage remains unclear. The results of this study provide a theoretical basis for the recovery of neurological function after diabetic cerebral hemorrhage and may provide a new targeted therapy for neuroinflammation.
Multi-omics data-based analysis characterizes molecular alterations of the vesicle genes in human colorectal cancer
Authors: Wang Xi , Wu Minmin , Zhang Wei , Liu Zhenqiong , Ding Yang , Xu Mengqi , Zhang Fengmei , He Zhiqiang , Tang Min , Tang Donge , Dai Yong
Published: January 2023

Background: Vesicular genes are crucial to the development of colorectal cancer. Understanding the molecular pathways behind colorectal carcinogenesis and identifying possible treatment targets can be accomplished by analyzing alterations in vesicle genes at multi-omics. Studies on the overall alteration of vesicle genes in colorectal cancer are still lacking, nevertheless.
Methods: In order to identify a potential association between vesicle genetic alterations and CRC progression, we analyzed molecular alterations in CRC vesicle genes at eight levels in this study, including mRNA, protein, and epigenetic levels. We also analyzed CRC overall survival related genes that were obtained from public database.
Results: The analysis of the chromatin structural variants, DNA methylation, chromatin accessibility, proteins, protein phosphorylation, ubiquitination, and malonylation of our collected CRC tissues in combination with the RNA-seq data from the TCGA database revealed the presence of multiple levels of alterations in CRC vesicle genes. We progressively examined the alterations of vesicle genes in mRNA and protein levels in CRC and discovered the hub genes COL5A1 and HSPA8. Further investigation identified the probable essential transcription factors YY1, CDX2, and CBX3.
Conclusions: This study contributes to a thorough knowledge of the connection between vesicle genes alterations in multiple level and the development of CRC and offers a theoretical framework for the identification of novel treatment targets.
A new fractional Cattaneo model for enhancing the thermal performance of Photovoltaic panels using heat spreader: Energy, exergy, economic and enviroeconomic (4E) analysis
Authors: El-Gazar Eman , Hassan Hamdy , Rabia Sherif , HU Changhong , Zahra Waheed
Published: January 2023

A new fractional non-Fourier (Cattaneo) photovoltaic (PV) model is developed to improve the thermal performance of a PV system combined with a heat spreader (HS). In contrast to the traditional Fourier model, which is unable to reliably predict system performance, the fractional Cattaneo model proves its efficiency in looking at transient processes throughout the entire PV system. It can also accurately expect PV performance even at short temporal scales. Consequently, a comparison is conducted between the classical Fourier model with the fractional Fourier and fractional Cattaneo models for the PV system. Real experimental data are used to validate the fractional Cattaneo model. The findings show that it perfectly matches the measured data, with an error percentage in PV power and exergy efficiency of only 0.628% and 3.84%, respectively, compared to 5.72% and 13.13% resulted from the classical model. An assessment of the effect of using rectangular and trapezoidal spreaders on output power, electrical efficiency, exergy efficiency, economic, exergoeconomic, and enviroeconomic parameters is introduced and discussed. The outcomes revealed that the electrical production costs of the rectangular and trapezoidal HS systems are 0.272 and 0.214 $/kWh, respectively, while about 0.286 $/kWh for the conventional PV panel. Finally, the findings show that the modified PV systems with the spreader are liked to be greener than the conventional ones.
Thermo economic assessment of photovoltaic/thermal panels-powered RO desalination unit combined with preheating using geothermal energy
Authors: Bacha Habib Ben , Abdullah Abdelkader Saad , Abdelgaied Mohamed , Kabeel Abd Elnaby
Published: January 2023

Recently, the reverse osmosis process is widely used in the field of desalinating brackish water and seawater to produce freshwater, but the disadvantage of using this technology is the increase in the rates of electrical energy consumption necessary to manage these units. To reduce the rates of electrical energy consumption in the RO desalination plants, geothermal energy was used as pre-heating system to heat feed water before entering RO desalination plants. The proposed system in this study consists of RO desalination plant with an energy recovery device, photovoltaic/thermal panels, and a geothermal energy extraction unit. To evaluate the system performance, three incorporated models were studied and validated by the previous experimental data. The results indicated that incorporating the geothermal energy and photovoltaic/thermal panels with the RO desalination plants has positive effects in terms of increasing productivity and reducing the rates of specific power consumption in RO desalination plants. The average saving in the specific power consumption for utilizing the thermal recovery system of PV panels and geothermal energy as preheating units reached 29.1% and 40.75% for treatment seawater and brackish water, respectively. Also, the economic feasibility showed that the saving the in the cost of freshwater produced from the RO desalination plants for incorporating both geothermal energy and photovoltaic panels with a thermal recovery system with reverse osmosis desalination plants up to 39.6%.
Effect of Bergmeister papilla on disc parameters in spectral domain optical coherence tomography
Authors: Chun Yeoun Sook , Moon Nam Ju , Kim Ungsoo Samuel , Yeo Joon Hyung , Jeong Jae Hoon
Published: January 2023

Background: To demonstrate the morphological characteristics of Bergmeister papilla (BMP), a persistent hyaloid remnant tissue, and its effects on the measurements and repeatability of spectral domain optical coherence tomography (OCT).
Methods: A prospective cross-sectional study was used to collect 83 patients with BMP and 76 age-matched unaffected individuals from a tertiary care institution. Imaging including 5-line raster and 3 consecutive optic disc cube scans centered on the optic disc were acquired using the Cirrus HD-OCT. Structural characteristics of BMP were classified according to the images of raster scans, and the repeatability of optic nerve head and retinal nerve fiber layer parameters was analyzed by calculating the test-retest standard deviation, coefficient of variance, and intraclass correlation coefficient.
Results: BMP was categorized into lifting edge (LE) type where does not cover the entire optic nerve head, but partially covers the corners, and covering disc (CD) type in which covers the entire cupping area like a cap. Among the BMP of 83 eyes, 58 (63.9%) were lifting edge type and 33 (36.1%) were CD type, and some of the optic nerve head parameters in OCT showed significant differences between the CD and LE types and normal control eyes. The analysis of repeatability showed that eyes with LE types affected cup volume and nasal retinal nerve fiber layer parameters and correlated with BMP location.
Conclusion: Because BMP might be a pitfall in OCT imaging, it is necessary to be careful when interpreting OCT in an eye with BMP.
Quantifying the uncertainty in future runoff projection over SSP scenarios, GCMs and hydrological model parameters
Authors: Kim Jin Hyuck , Chung Eun Sung , Song Jae Yeol , Shahid Shamsuddin
Published: January 2023

This study evaluated the inherent uncertainty of future runoff prediction using eleven Coupled Model Intercomparison Project 6 (CMIP6) global climate models (GCMs) and a hydrological model (HM). The soil and water assessment tool (SWAT) model was used as a hydrologic model, and SWAT-CUP was used for parameter calibration. The future runoff projection was simulated utilizing two shared socioeconomic pathways (SSPs) scenarios, SSP2-4.5 and SSP5-8.5, for near (2021–2060) and far (2061–2100) futures. Jensen-Shannon divergence (JS-D) was used to quantify the uncertainties between the past and future probability distributions considering different GCMs and calibrated parameter sets of HM. The JS-D value for each GCM and calibrated HM parameter set was calculated at the range of 0.026–0.075 and 0.035–0.058, respectively. As a result, the uncertainty in the selection of GCMs was found to be greater than in the determination of values for HM parameters. Bayesian model averaging (BMA), which is a statistical approach that can combine estimations from multiple models and produce reliable probabilistic predictions, was applied to quantify the uncertainty by each GCM and HM parameters. When estimating the future runoff, INM-CM4-8 caused the greatest uncertainty, and the calibrated set of HM parameters using the year of high runoff caused the greatest uncertainty. This approach can help the uncertainty analysis in the future runoff estimation.
Impact of hormone replacement therapy on all-cause and cancer-specific mortality in colorectal cancer: A systematic review and dose‒response meta-analysis of observational studies
Authors: Liu Kefeng , He Yazhou , Zhang Xianzhuo , Yang Yongjie , Sun Shusen , Mei Zubing , Zhao Jie
Published: January 2023

Background
The effect of hormone replacement therapy (HRT) on colorectal cancer (CRC) mortality and all-cause mortality remains unclear. We conducted a systematic review and dose‒response meta-analysis to determine the effects of HRT on CRC mortality and all-cause mortality.
Methods
We searched the PubMed, Embase, and Cochrane Library electronic databases for all relevant studies published until June 2022 to investigate the effects of HRT exposure on survival rates for patients with CRC. Two reviewers independently extracted individual study data and evaluated THE risk of bias among the studies using the Newcastle‒Ottawa Scale. To examine a potential nonlinear relationship between the year of HRT use and CRC mortality, we performed a two-stage random effects dose‒response meta-analysis.
RESULTS
Ten cohort studies encompassing 480,628 individuals were included. The meta-analysis revealed that HRT was inversely associated with the risk of CRC mortality [hazard ratios (HR) = 0.77, 95% CI (0.68, 0.87), I2 = 69.5%, P < 0.05]. Pooled results from seven cohort studies revealed a significant association between HRT and the risk of all-cause mortality [HR = 0.71, 95% CI (0.54, 0.92), I2 = 89.6%, p < 0.05]. A linear (P for nonlinearity = 0.34) dose‒response analysis showed a 3% decrease in the risk of CRC for each additional year of HRT use; this decrease was significant [HR = 0.97, 95% CI(0.94, 0.99), P < 0.05]. An additional linear (P for nonlinearity = 0.88) dose‒response analysis showed a nonsignificantly decrease in the risk of all-cause mortality for each additional year of HRT use.
CONCLUSIONS
This study suggests that the use of HRT is inversely associated with all-cause and colorectal cancer mortality, thus causing a significant decrease in mortality rates over time. Further studies are warranted to confirm this association.
Vascular regeneration and skeletal muscle repair induced by long-term exposure to SDF-1α derived from engineered mesenchymal stem cells after hindlimb ischemia
Authors: Park Hun-Jun , Kim Jin-Ju , Park Jae-Hyun , Kim Hyeok , Sim Woo-Sup , Hong Seokbeom , Choi Yeon-Jik , Kim Hyo-Jin , Lee Soon Min , Ban Kiwon
Published: January 2023

Despite the recent progress in medical and endovascular therapy, the prognosis for patients with critical limb ischemia (CLI) remains poor. In response, various stem cells and growth factors have been assessed for use in therapeutic neovascularization and limb salvage in CLI patients. However, the clinical outcomes of cell-based therapeutic angiogenesis have not provided the promised benefits, reinforcing the need for novel cell-based therapeutic angiogenesis strategies to cure untreatable CLI patients. In the present study, we investigated genetically engineered mesenchymal stem cells (MSCs) derived from human bone marrow that continuously secrete stromal-derived factor-1α (SDF1α-eMSCs), and demonstrated that intramuscular injection of SDF1α-eMSCs can provide long-term paracrine effects in limb ischemia and effectively contribute vascular regeneration as well as skeletal muscle repair through increased phosphorylation of the ERK and Akt within the SDF1α/CXCR4 axis. These results provide compelling evidence that genetically engineered MSCs with SDF-1α can be an effective strategy for successful limb salvage in limb ischemia.
Congenital hepatic hemangioma: An unusual case report of pulmonary hypertension
Authors: Zhou Qianqin , Juan Jiang , Xu Yinquan , Qiu Hanyan , Wen Xiaoyan , He Shaoqi , Lv Qin
Published: January 2023

Background: Pulmonary hypertension (PH) in a newborns is a rare but serious condition that often requires immediate intervention and quick diagnosis of the correct etiologyto prevent mortality. Congenital hepatic hemangioma (CHH) is an example of an extrathoracic etiology of PH.
Case presentation: Herein, we report the case of a newborn with a giant liver hemangioma, who presented with an early onset of PH and was successfully treated with intra-arterial embolization.
Conclusions: This case illustrates the importance of suspicion and prompt evaluation of CHH and related systemic arteriovenous shunts among infants with unexplained PH.
Optimization of mullite-based chamotte production as a result of calcination of a kaolin-boron waste mixture by response surface method and its usability in ceramic
Authors: Bulut Firdevs , Taşdemir Tuba , Tatar İlknur
Published: January 2023

This study aims to use kaolin and boron waste in the production of Chamotte material. The usability of the produced chamotte in the FFC (fine fire clay) body in sanitary wares, instead of the chamotte supplied from abroad, was also investigated. The studies were carried out using a statistical experimental design and aimed to reach more information with a small number of experiments. The percentage of boron content, calcination temperature and grinding time factors were examined as independent variables, and the effects of these factors on the percentage of mullite phase, anorthite phase, quartz phase and sodium aluminum silicate phase were examined. Thus, the interaction of the parameters both individually and with each other was revealed, and the process was modeled with a mathematical model that is a function of independent variables. In addition, with an optimization study that provides the desired product feature with the least possible cost, the properties of the vitrified product obtained with both the produced chamotte and the reference chamotte were compared. When the chamotte, produced by optimizing the experimental design, was added to the vitrified body, this product achieved an improvement 32.73% in strength, 5.88% in shrinkage, and 4.67% in water absorption compared to the reference factory chamotte. As a result, with the current study, it has been determined that when both waste kaolin and boron are calcined together, fireclay with better properties can be obtained instead of imported fireclay and can be used industrially.
Labour market participation after a sickness absence due to cancer: a dynamic cohort study in Catalonia (Spain)
Authors: Ayala-Garcia Amaya , Benavides Fernando G. , Serra Laura
Published: January 2023

Background: The consequences of cancer on working life until retirement age remain unclear. This study aimed to analyse working life considering all possible labour market states in a sample of workers after an SA due to cancer, and to compare their working life paths to those of a sample of workers without SA and with an SA due to other diseases.
Methods: Registry-based cohort study of social security affiliates in Catalonia from 2012-2018. Cases consisted of workers with an SA due to cancer between 2012-2015 (N=516) and were individually age- and sex-matched with an affiliate with an SA due to other diagnoses and a worker without an SA. All workers (N=1,548, 56% women) were followed-up from the end of the SA due to cancer until the end of 2018 to characterise eight possible weekly labour states. Sequence analysis, optimal matching, and multinomial logistic regression were used to identify and assess the probability of future labour market participation patterns (LMPP). All analyses were stratified by sex.
Results: Compared with workers with an SA due to cancer, male workers with no SA and SA due to other causes showed a lower probability of being in the LMPP of death (aRRR 0.02, 95% CI: 0.00‒0.16; aRRR 0.17, 95% CI: 0.06‒0.46, respectively), and in women lower probability of increasing permanent disability and death (aRRR 0.24, 95% CI: 0.10‒0.57; aRRR 0.39, 95% CI: 0.19‒0.83, respectively). Compared to workers with SA due to cancer, risk of future retirement was lower in workers with no SA (women aRRR 0.60, 95%CI: 0.22‒1.65; men aRRR 0.64, 95%CI: 0.27‒1.52).
Conclusions Workplaces should be modified to the needs of cancer survivors, many of which are common to all diagnoses, in order to prevent more frequent retirement and permanent disability when possible. Further studies should assess the impact of cancer on premature exit from the labour market among survivors, depending on cancer localisation and type of treatment.
Single-cell sequencing reveals increased LAMB3+ basal keratinocytes and ZNF90+ fibroblasts in autologous cultured epithelium under serum- and feeder-free conditions
Authors: Lian Weiling , Zeng Xuanhao , Li Jian , Liu Yating , Lv Haozhen , Chen Shujun , Huang Shiyi , Shen Jiayi , Zang Qing , Tang Luyan , Wu Fuyue , Zhang Qi , Xu Jinhua
Published: January 2023

Autologous cultured epithelium grafting (ACEG) is a promising treatment for refractory vitiligo. Concerns for infections or immunological reactions caused by serum and feeder used in culture medium may limit the use for surgical interventions. Here, we cultured autologous epithelium under serum- and feeder-free (SFF) conditions and compared its safety and efficacy with epithelium cultured under serum- and feeder-dependent (SFD) conditions in patients with stable vitiligo. Then, single-cell RNA transcriptomics of SFF and SFD cultured epithelium and healthy skin were conducted. There were no significant differences in repigmentation between the SFF and the SFD conditioned grafting. Increased LAMB3 + basal keratinocytes and ZNF90 + fibroblasts were found in the SFF epithelial sheets. The LAMB3 + basal keratinocytes had active cellular metabolism and participated in extracellular matrix homeostasis. The ZNF90 + fibroblasts were more differentiated and implicated in collagen formation for cell adhesion. Both the LAMB3 + basal keratinocytes and the ZNF90 + fibroblasts were more involved in the interactions with melanocytes in the SFF epithelial sheets compared to the SFD epithelial sheets. Our findings support the LAMB3 + basal keratinocytes and the ZNF90 + fibroblasts as key factors behind the repigmentation in ACEG under SFF conditions. The study provides translational insights into ACEG repigmentation and potential therapeutic targets for vitiligo.
Palaeo-environmental reconstruction of pedogenic calcretes in Sathankulam, Southern India: an integrated approach
Authors: Velmayil Perumal , Venu Udayanapillai Alagaiah
Published: January 2023

A widespread and thick calcrete level occurs as an intervening deposit between soil surface and Proterozoic hard metamorphic granite (or) Tertiary calcareous sandstone basement rocks of Sathankulam region, Thoothukudi district of Tamilnadu, India. Field observation reveals the nature of calcrete deposits as gravel, chalky, laminated, massive, and nodular forms. Photomicrographs of calcrete thin sections reveal calcified macrocystis, calcified fungal hyphae, calcified microtubules, peloidal, calloforms with clay clast rimmed by micritic calcite, sesquioxide preservation and micritic calcite preservation in septarian nodules. X-ray diffraction analysis of calcrete profile samples reveals predominance of micritic calcite and limited occurrence of clay minerals of sepiolite, palygorskite, and other grains of quartz, feldspar, hornblende, biotite, and gypsum. Geochemical studies of two calcrete profile samples show the predominance of major elements of CaO, Al2O3, MgO, Fe2O3, minor/trace elements of Ba, Nb, Zr, Y, Sr, Rb, Ga, Zn, Ni, Cu, and Cr and rare earth elements/chondrite values of La, Ce, Pr, Nd, Sm, Gd, and Dy. Statistical evaluation of all major, minor/trace, and rare earth elements through multiple correlations, principal component analysis, and cluster analysis establish the inter-relationship and affinities between the parameters of the source elements of the two profiles. Stable isotope study of δ13C and δ18O of Hudson diagenitic plot study reveals that the two calcrete profile samples represent the reconstruction of palaeo-diagentic environmental condition as meteoric cement and continental freshwater limestone depositional environment. Further, stable isotope analysis of the area plotted on Julian Andrews and Keith and Weiber standard plot represents the weaker monsoonal climate and meteoric-diagenetic environment respectively.