bluuebunny/crossref_metadata_2025 huggingface dataset:
Asking the Right Questions? A Critical Overview of Longitudinal Survey Data on Intimate Partner Violence and Abuse Among Adults and Young People in the UK
Authors: Skafida Valeria , Feder Gene , Barter Christine
Published: March 2023

Purpose

We undertake a critical analysis of UK longitudinal and repeated cross-sectional population surveys which ask about experiences of intimate partner violence and abuse (IPVA).

Method

Seven relevant UK representative population-based surveys which ask about IPVA among adults and/or young people (16–17 years old) were identified. We critically engage with the questionnaires to analyse the strengths and limitations of existing UK data on IPVA.

Results

Several limitations in UK surveys are identified. Many questions still show a bias, partly historical, towards collecting more data about physical abuse. Few surveys ask about financial abuse, abuse post-separation or through child contact, or through technologies, though improvements are under way. Surveys still seek to count incidents of abuse, instead of enquiring about the impact of abusive behaviours on victims. Ethnicity and other demographic variables are not always adequately captured (or accessible to data users), making it difficult to explore aspects of inequality. Potentially useful comparisons within the UK are difficult to undertake given the increasingly divergent questionnaires used in different UK nations.

Conclusions

We discuss how future iterations of existing surveys or new surveys can improve with regards to how questions about IPVA are asked. Given that surveys across geographical contexts often suffer similar weaknesses, our findings will be relevant for IPVA survey methodology beyond the UK context.
Ethical challenges of clinical trials with a repurposed drug in outbreaks
Authors: Klas Katarzyna , Strzebonska Karolina , Waligora Marcin
Published: March 2023

Drug repurposing is a strategy of identifying new potential uses for already existing drugs. Many researchers adopted this method to identify treatment or prevention during the COVID-19 pandemic. However, despite the considerable number of repurposed drugs that were evaluated, only some of them were labeled for new indications. In this article, we present the case of amantadine, a drug commonly used in neurology that attracted new attention during the COVID-19 outbreak. This example illustrates some of the ethical challenges associated with the launch of clinical trials to evaluate already approved drugs. In our discussion, we follow the ethics framework for prioritization of COVID-19 clinical trials proposed by Michelle N Meyer and colleagues (2021). We focus on four criteria: social value, scientific validity, feasibility, and consolidation/collaboration. We claim that launching amantadine trials was ethically justified. Although the scientific value was anticipated to be low, unusually, the social value was expected to be high. This was because of significant social interest in the drug. In our view, this strongly supports the need for evidence to justify why the drug should not be prescribed or privately accessed by interested parties. Otherwise, a lack of evidence-based argument could enhance its uncontrolled use. With this paper, we join the discussion on the lessons learned from the pandemic. Our findings will help to improve future efforts to decide on the launch of clinical trials on approved drugs when dealing with the widespread off-label use of the drug.
International research collaboration: is Africa different? A cross-country panel data analysis
Authors: Cerdeira Jorge , Mesquita João , Vieira Elizabeth S.
Published: March 2023

International research collaboration (IRC) has been relevant for the development of national scientific systems. In Africa, given the limited resources devoted to research and development (R&D) activities and the crucial role that scientific knowledge generated through research activities can have in socioeconomic development, IRC may be an opportunity to strengthen scientific capabilities. While geographical, economic, political/governance, cultural, intellectual and excellence distance hampers IRC in other regions, we argue that economic and excellence distances actuate differently in Africa. We explored the impact of the variables above in addition to the information and communication technologies (ICTs), and social distances on the IRC of these countries. Using panel data for 54 African economies, our results show that economic distance fosters IRC while governance and excellence distances are non-significant. Past collaborations (one out of two proxies for social distance) and speaking the same language have the highest effect on IRC, and ICTs distance the lowest. The results have implications for science policy in Africa. For instance, we argue that science policies need to be adapted to each environment as the scientific landscape in each country is unique.
Addressing racial misinformation at school: a psycho-social intervention aimed at reducing ethnic moral disengagement in adolescents
Authors: D’Errico Francesca , Cicirelli Paolo Giovanni , Corbelli Giuseppe , Paciello Marinella
Published: March 2023

The present study aims to examine whether by promoting the socio-analytic thinking it is possible to intervene in the reliance on ethnic moral disengagement as a negative consequence of racial misleading news, that can seriously contribute to the diffusion of ethnic prejudice. We focus on the neglected phenomenon of racial hoaxes, which can be defined as misleading news stories dealing with health or safety threats, in which the protagonist is described in terms of ethnicity or nationality. The intervention procedure has been created starting from the well-established literature focused on media biases’ reflection, integrated with the recent studies on ‘mediated intergroup contact’ where the observation of the person belonging to the outgroup is crucial for prejudice reduction. The intervention involved 83 adolescents (Mage = 13.9; SDage = 0.9) and it was composed of two different parts, one focused on the analytical racial hoax reading, and the other focused on racial hoax rewriting after the ‘mediated contact’, represented by an alternative story given by the African protagonist. The results show that in dealing with misleading news, the promotion of this social-analytic processing reduces ethnic biases of moral disengagement. In particular, it was found that analytical processes are supported by the participants’ level of propensity for analytical reasoning and that these processes directly hinder distorted ethnic beliefs. Overall, these results suggest that improving social-analytic processes related to reflexivity could be an effective intervention to counter those distorted beliefs, such as ethnic disengagement beliefs, associated with discrimination and racial prejudice.
Duality for Sets of Strong Slater Points
Authors: Rodríguez Margarita M. L. , Vicente-Pérez José
Published: March 2023

The strong Slater condition plays a significant role in the stability analysis of linear semi-infinite inequality systems. This piece of work studies the set of strong Slater points, whose non-emptiness guarantees the fullfilment of the strong Slater condition. Given a linear inequality system, we firstly establish some basic properties of the set of strong Slater points. Then, we derive dual characterizations for this set in terms of the data of the system, following similar characterizations provided also for the set of Slater points and the solution set of the given system, which are based on the polarity operators for evenly convex and closed convex sets. Finally, we present two geometric interpretations and apply our results to analyze the strict inequality systems defined by lower semicontinuous convex functions.
Who Gains Mental Health Benefits from Work Autonomy? The Roles of Gender and Occupational Class
Authors: Lu Zhuofei , Wang Senhu , Li Yaojun , Liu Xiyuan , Olsen Wendy
Published: March 2023

In recent years, improving work autonomy as an important priority in the UK labour market has been shown to enhance employee mental health and well-being. However, previous theories and empirical studies have paid little attention to the intersectional inequalities in the mental health benefits of work autonomy, preventing us from gaining a comprehensive understanding of the mental consequences of work autonomy. By integrating literature from occupational psychology, gender and social class, this study develops theoretical hypotheses regarding whether and how the mental health benefits of work autonomy vary alongside the intersectional axes of gender and occupational class and tests these hypotheses using long-term panel data in the UK (2010–2021). Overall, we find that those from higher occupational class and male employees acquire significantly more mental health benefits from high work autonomy compared with those from lower occupational class and female employees. Moreover, further analyses show significant intersectional inequalities of gender and occupational class. While male employees from all occupational classes gain significant mental health benefits from work autonomy, only female employees from higher (but not lower) occupational classes benefit from work autonomy. These findings contribute to the literature in the sociology of work by demonstrating the intersectional inequalities in mental health consequences of work autonomy, especially for women in the lower occupational class, highlighting the need for a more gender- and occupation-sensitive design in future labour market policies.
Multipolar Hardy inequalities and mutual interaction of the poles
Authors: Canale Anna
Published: March 2023

In this paper we state the weighted Hardy inequality $$\begin{aligned} c\int _{{{\mathbb {R}}}^N}\sum _{i=1}^n \frac{\varphi ^2 }{|x-a_i|^2}\, \mu (x)dx\le \int _{{{\mathbb {R}}}^N} |\nabla \varphi |^2 \, \mu (x)dx +k \int _{\mathbb {R}^N}\varphi ^2 \, \mu (x)dx \end{aligned}$$

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Musculoskeletal manifestations in children with Behçet’s syndrome: data from the AIDA Network Behçet’s Syndrome Registry
Authors: Gaggiano Carla , Maselli Anna , Sfikakis Petros P. , Laskari Katerina , Ragab Gaafar , Hegazy Mohamed Tharwat , Laymouna Ahmed Hatem , Lopalco Giuseppe , Almaghlouth Ibrahim A. , Asfina Kazi Nur , Alahmed Ohoud , Giardini Mayrink Henrique Ayres , Parente de Brito Antonelli Isabele , Cattalini Marco , Piga Matteo , Sota Jurgen , Gentileschi Stefano , Maggio Maria Cristina , Opris-Belinski Daniela , Hatemi Gülen , Insalaco Antonella , Olivieri Alma Nunzia , Tufan Abdurrahman , Karadeniz Hazan , Kardaş Riza Can , La Torre Francesco , Cardinale Fabio , Marino Achille , Guerriero Silvana , Ruscitti Piero , Tarsia Maria , Vitale Antonio , Caggiano Valeria , Telesca Salvatore , Iannone Florenzo , Parretti Veronica , Frassi Micol , Aragona Emma , Ciccia Francesco , Wiesik-Szewczyk Ewa , Ionescu Ruxandra , Şahin Ali , Akkoç Nurullah , Hinojosa-Azaola Andrea , Tharwat Samar , Hernández-Rodríguez José , Espinosa Gerard , Conti Giovanni , Del Giudice Emanuela , Govoni Marcello , Emmi Giacomo , Fabiani Claudia , Balistreri Alberto , Frediani Bruno , Rigante Donato , Cantarini Luca ,   the AIDA Network
Published: March 2023

This study aims to describe musculoskeletal manifestations (MSM) in children with Behçet’s syndrome (BS), their association with other disease manifestations, response to therapy, and long-term prognosis. Data were retrieved from the AIDA Network Behçet’s Syndrome Registry. Out of a total of 141 patients with juvenile BS, 37 had MSM at disease onset (26.2%). The median age at onset was 10.0 years (IQR 7.7). The median follow-up duration was 21.8 years (IQR 23.3). Recurrent oral (100%) and genital ulcers (67.6%) and pseudofolliculitis (56.8%) were the most common symptoms associated with MSM. At disease onset, 31 subjects had arthritis (83.8%), 33 arthralgia (89.2%), and 14 myalgia (37.8%). Arthritis was monoarticular in 9/31 cases (29%), oligoarticular in 10 (32.3%), polyarticular in 5 (16.1%), axial in 7 (22.6%). Over time, arthritis became chronic-recurrent in 67.7% of cases and 7/31 patients had joint erosions (22.6%). The median Behçet's Syndrome Overall Damage Index was 0 (range 0–4). Colchicine was inefficacious for MSM in 4/14 cases (28.6%), independently from the type of MSM (p = 0.46) or the concomitant therapy (p = 0.30 for cDMARDs, p = 1.00 for glucocorticoids); cDMARDs and bDMARDs were inefficacious for MSM in 6/19 (31.4%) and 5/12 (41.7%) cases. The presence of myalgia was associated with bDMARDs inefficacy (p = 0.014). To conclude, MSM in children with BS are frequently associated with recurrent ulcers and pseudofolliculitis. Arthritis is mostly mono- or oligoarticular, but sacroiliitis is not unusual. Prognosis of this subset of BS is overall favorable, though the presence of myalgia negatively affects response to biologic therapies. ClinicalTrials.gov Identifier: NCT05200715 (registered on December 18, 2021).
Value relevance of voluntary intellectual capital disclosure: a meta-analysis
Authors: Rieg Robert , Vanini Ute
Published: March 2023

Because mandatory disclosure of intellectual capital (IC) is restricted by accounting regulations, companies invest in voluntary IC disclosure (ICD) to reduce information asymmetries and support an adequate firm valuation by investors and other stakeholders. So far numerous studies analysing the value relevance of voluntary ICD have been published revealing mixed results. Thus, it is the purpose of this paper to statistically integrate and to explain the heterogeneity of results by applying a meta-analysis with 122 effects of 40 primary studies. Our results mainly support the value relevance of voluntary ICD resulting in higher market value, lower cost of equity, and higher accounting performance. We identify weak moderating effects for legal origin, different IC categories and journal ranking. For further improving of disclosure quality, standard setters should develop disclosure standards for voluntary ICD. To reduce the heterogeneity of future studies a standardised scale for the measurement of voluntary ICD should be developed and applied.
Bacterial translocation occurs early in cirrhosis and triggers a selective inflammatory response
Authors: Simbrunner Benedikt , Caparrós Esther , Neuwirth Teresa , Schwabl Philipp , Königshofer Philipp , Bauer David , Marculescu Rodrig , Trauner Michael , Scheiner Bernhard , Stary Georg , Mandorfer Mattias , Reiberger Thomas , Francés Rubén
Published: March 2023

Background

Experimental data suggest that bacterial translocation (BT) promotes systemic inflammation, portal hypertension, and circulatory dysfunction in advanced chronic liver disease (ACLD).

Methods

Patients with ACLD undergoing hepatic venous pressure gradient (HVPG) measurement and absence of acute decompensation or infections were included (n = 249). Serum biomarkers of BT (lipopolysaccharide [LPS], lipoteichoic acid [LTA], bacterial DNA [bactDNA]), systemic inflammation and markers of circulatory dysfunction were assessed. T-cell subsets in intestinal biopsies (n = 7 ACLD, n = 4 controls) were analyzed by flow cytometry.

Results

Patients had a median HVPG of 18 (12–21) mmHg and 56% had decompensated ACLD. LPS (0.04 [0.02–0.06] vs. 0.64 [0.30–1.06] EU/mL), LTA (4.53 [3.58–5.97] vs. 43.2 [23.2–109] pg/mL), and detection of bactDNA (≥ 5 pg/mL; 5% vs. 41%) were markedly higher in patients with ACLD than healthy controls (n = 40; p < 0.001) but were similar between different clinical stages of compensated and decompensated ACLD and displayed no meaningful correlation with HVPG and systemic hemodynamics. TNF-α and IL-10 correlated with LPS (Spearman’s rs = 0.523, p < 0.001/rs = 0.143, p = 0.024) but not with LTA. Presence of bactDNA was associated with higher LPS (0.54 [0.28–0.95] vs. 0.88 [0.32–1.31] EU/mL, p = 0.001) and TNF-α (15.3 [6.31–28.1] vs. 20.9 [13.8–32.9] pg/mL). Patients with ACLD exhibited a decreased CD4:CD8-ratio and increased TH1-cells in the intestinal mucosa as compared to controls. During a median FU of 14.7 (8.20–26.5) months, bacterial antigens did not predict decompensation or liver-related death (in contrast to HVPG, IL-6, and MAP) as well as infections at 24 months.

Conclusion

BT occurs already in early ACLD stages and triggers a systemic inflammatory response via TNF-α and IL-10. Interestingly, BT markers showed no clear correlation with portal hypertension and circulatory dysfunction in patients with stable ACLD.

Clinical trial number

NCT03267615.
Measuring Childhood Exposure to Neighbourhood Deprivation at the Macro- and Micro-level in Aotearoa New Zealand
Authors: Rudd Georgia , Meissel Kane , Meyer Frauke
Published: March 2023

Neighbourhood effects research has benefited from the application of sequence analysis which, together with cluster analysis, identifies the main temporal patterns of exposure to residential contexts experienced by different groups of people, such as children. However, given that this is a relatively new approach to measuring exposure to neighbourhood deprivation, studies that have utilised sequence analysis to model residential trajectories and test for neighbourhood effects do not contextualise these population-level findings at the individual-level. The current study sought to investigate the patterns of exposure to neighbourhood deprivation experienced by children in Aotearoa New Zealand over the first eight years of life by utilising two different methodological approaches: at the macro-level, the results of the sequence and cluster analysis suggest that in general, children experienced little neighbourhood mobility; at the micro-level, children experienced greater levels of movement between different levels of neighbourhood deprivation in middle childhood, compared to early childhood, while children in the least and most deprived neighbourhoods experienced less mobility than their peers. Together, these findings provide a comprehensive description of the ways in which children are exposed to different residential contexts over time and advance our understandings of how to document these experiences effectively within quantitative research.
Ethics 4.0: Ethical Dilemmas in Healthcare Mediated by Social Robots
Authors: Soares Antonio , Piçarra Nuno , Giger Jean-Christophe , Oliveira Raquel , Arriaga Patrícia
Published: March 2023

This study examined people’s moral judgments and trait perception toward a healthcare agent’s response to a patient who refuses to take medication. A sample of 524 participants was randomly assigned to one of eight vignettes in which the type of healthcare agent (human vs. robot), the use of a health message framing (emphasizing health-losses for not taking vs. health-gains in taking the medication), and the ethical decision (respect the autonomy vs. beneficence/nonmaleficence) were manipulated to investigate their effects on moral judgments (acceptance and responsibility) and traits perception (warmth, competence, trustworthiness). The results indicated that moral acceptance was higher when the agents respected the patient’s autonomy than when the agents prioritized beneficence/nonmaleficence. Moral responsibility and perceived warmth were higher for the human agent than for the robot, and the agent who respected the patient’s autonomy was perceived as warmer, but less competent and trustworthy than the agent who decided for the patient’s beneficence/nonmaleficence. Agents who prioritized beneficence/nonmaleficence and framed the health gains were also perceived as more trustworthy. Our findings contribute to the understanding of moral judgments in the healthcare domain mediated by both healthcare humans and artificial agents.
Anhydrite Weathering Zone with Hydration Caves at Dingwall (Nova Scotia, SE Canada) as a Potential Geosite and Geodiversity Site
Authors: Jarzyna Adrian , Bąbel Maciej , Ługowski Damian , Vladi Firouz
Published: March 2023

The abandoned gypsum quarry at Dingwall, in Canada, is a unique place with a peculiar “living” landscape created by expansive hydration of anhydrite process actively operating in the weathering zone at the quarry bottom. It causes a rapid volume increase of the rocks and the formation of the unique domed and tepee-like hydration landforms (several meters in length and up to 2.09 m high) with internal hydration caves (swelling caves, German: Quellungshöhlen). The quarry also shows some rare evaporite minerals, sulphate karst, spheroidal weathering of anhydrite and the other phenomena. Several steps of geoconservation strategy are described to promote Dingwall quarry as a geosite and a geodiversity site: inventory, quantitative assessment, conservation, interpretation, promotion and monitoring. The performed inventory describes the elements of the geoheritage. The quantitative assessment of the site, made according to the method by Brilha (Geoheritage 8:119–134, 2016), was based on the four aspects: scientific value, potential educational use, potential tourist use and the rate of destruction. For showing the geological heritage, the plan of the site was prepared, with paths for visitors, attendant infrastructure, thematic interpretation panels and plates with QR codes. As a part of the promotion, application of the Internet with already operating sites (e.g. hydrationcave.com) is proposed. In turn, monitoring, with measurements of benchmarks and photographic and photogrammetric documentation, will ensure the proper functioning of the site after establishing it as a geosite and a geodiversity site.
Opportunities and Challenges Associated with Bioavailability-Based Remediation Strategies for Lead-Contaminated Soil with Arsenic as a Co-Contaminant—A Critical Review
Authors: Kastury Farzana , Li Hongbo , Karna Ranju , Betts Aaron , Scheckel Kirk G. , Ma Lena Q. , Sowers Tyler D. , Bradham Karen D. , Hettiarachchi Ganga M. , Juhasz Albert L.
Published: March 2023

Purpose of Review

The ubiquity of soil contamination by lead (Pb) and arsenic (As) has prompted the development of numerous techniques for its remediation. For human health exposure assessment, oral bioavailability-based methods are the most suitable to assess the efficacy of these treatment strategies, including in vivo relative bioavailability (systemic absorption relative to a toxicity reference) and in vitro bioaccessibility (dissolution in simulated gastrointestinal solutions). This paper provides a critical review of opportunities and challenges associated with the immobilization of Pb and As in contaminated soil.

Recent Findings

This review identified that the major inorganic and organic amendments used to reduce Pb and As exposure include phosphate, industrial by-products, metal oxides, organic matter, biochar, and treatment with iron sulphate to promote the formation of plumbojarosite in soil. In addition to RBA and IVBA assessment, investigating changes in Pb/As speciation in untreated vs treated soil can provide additional confirmation of treatment efficacy. The results of this review showed that immobilization efficacy may vary depending on amendment type, Pb, and As speciation in soil and the approach used for its assessment.

Reducing childhood exposure to Pb and As is a significant challenge, given the variety of contamination sources and treatment strategies. A lines-of-evidence approach using standardized methodologies is recommended for the assessment of immobilization efficacy to ensure exposure and risk reduction

Graphical Abstract

Bioavailability-based remediation strategies. Popular soil amendments to reduce Pb exposure include phosphate, industrial by-products, metal oxides, organic matter, and biochar; however, these may increase As exposure. The plumbojarosite formation technique has been recently developed to mitigate Pb and As exposure simultaneously. Multiple lines-of-evidence approach is recommended to assess treatment efficacy
Integrated photonics in quantum technologies
Authors: Giordani Taira , Hoch Francesco , Carvacho Gonzalo , Spagnolo Nicolò , Sciarrino Fabio
Published: March 2023

Quantum information processing is nowadays an established branch of quantum mechanics applications. Recent results in different areas, ranging from communications to computing, show that quantum technologies are advancing towards being mature platforms with substantial advantages over traditional classical protocols. Quantum optics and photonic apparatuses are one of the best candidates for the realization of quantum processors. In this context, integrated photonic technologies are essential components towards miniaturisation of such complex optical systems. Integrated optical devices enabled an important improvement in the level of complexity in the generation and processing of quantum states of light. This review aims at providing an exhaustive framework of the advances of integrated quantum photonic platforms, for what concerns the integration of sources, manipulation, and detectors, as well as the contributions in quantum computing, cryptography and simulations.
Assessing the efficacy of un and gamma-irradiated entomopathogenic nematode, Steinernema carpocapsae as an eco-friendly approach to control Agrotis ipsilon larvae
Authors: Sayed Rehab Mahmoud , El Sayed Tammy Samir , Rizk Salwa Abdou
Published: March 2023

The black cutworm, Agrotis ipsilon (Hufnagel) is one of the most devastating agricultural pests that attack different crops worldwide. Entomopathogenic nematodes (EPNs) have been utilized in classical, conservation, and augmentative biological control programs. Consequently, this study was designed to estimate the efficacy of an unirradiated and gamma-irradiated entomopathogenic nematode, Steinernema carpocapsae (all), against A. ipsilon larvae as a safe control tool to reduce chemical environmental hazards. The virulence of different concentrations (10, 20, 30 and 40 IJs/ml) of unirradiated and gamma-irradiated (with 2 Gy) of S. carpocapsae was evaluated. Changes in peroxidase (Px) and polyphenyl oxidase (PPO) zymographic patterns were also investigated after larvae were treated with LC50 values for S. carpocapsae. The results revealed that larval mortality increased with increasing S. carpocapsae concentration and time after treatment. The 2 Gy gamma-irradiated S. carocapsae caused a greater pathogenic effect than the unirradiated S. carocapsae, where the LC50 values of 2 Gy gamma-irradiated S. carocapsae were 31.19 and 17.78 IJs/ml after 1 and 2 days, respectively, compared to 113.23 and 65.83 IJs/ml for unirradiated S. carocapsae. For the toxicity index, gamma irradiation at a dose of 2 Gy was selected and given an arbitrary 100 units and considered a standard treatment. Analysis of gel electrophoresis revealed 3 bands of Px and PPO in control larvae; treatment with unirradiated and irradiated S. carpocapsae caused the disappearance of the first band of both enzymes and lowered the intensity of the other 2 bands. The laboratory studies revealed that 2 Gy gamma-irradiated S. carpocapsae could be used as an eco-safe management tool against A. ipsilon larvae under field conditions.
Music Speaks
Authors: Albright Daniel
Published: March 2023

Explores the meaning[s] of music, the most intricate and significant language invented by our culture.
Desintegración y justicia en el cine argentino contemporáneo
Authors: Copertari Gabriela
Published: March 2023

Películas que dan cuenta de la desintergración de la imagen de Argentina como tierra de oportunidades y progreso.
Poetry and Loss
Authors: Roberts Nicholas
Published: March 2023

The first book-length account in English of Montejo's life and work.
The Royal Pardon: Access to Mercy in Fourteenth-Century England
Authors: Lacey Helen
Published: March 2023

Pioneering investigation of the royal pardon, at a time of major change in the system of English justice, showing the important part it continued to play.
Treacherous Foundations
Authors: Coates Geraldine
Published: March 2023

Representations of treachery in medieval and early modern Spain.
Incompressible potential flow about complete aircraft configurations
Authors: Singh N. , Aikat S. , Basu B. C.
Published: March 2023

An economic numerical method has been developed to calculate the incompressible potential flow about complete aircraft configurations by taking advantage of the computational efficiency of the internal distribution of singularities. For wing and wing-like components, source and vorticity singularities are distributed on the respective mean camber surfaces, while the fuselage carries a source distribution on its wetted surface. The singularity strengths are obtained by satisfying the flow tangency condition at selected points on all the wetted surfaces of the configuration. No attempt has been made to consider wing or body vortex shedding or separation. The results of the present method were compared with other theoretical and experimental data.
The effect of trailing edge extensions on the performance of the Göttingen 797 and the Wortmann FX 63-137 aerofoil sections at Reynolds numbers between 3 x 105 and 1 x 106
Authors: Ito A.
Published: March 2023

The effect of trailing edge extensions was tested for the twodimensional Göttingen 797 and Wortmann FX 63-137 aerofoil sections with smooth surfaces at chord Reynolds numbers from 3 x 105 to 1 x 106 in the 8ft x 6ft low speed wind-tunnel at the Cranfield Institute of Technology. Force measurements were made on the basic aerofoil sections and with extension plates of 10% and 20% chord set tangential to the upper surface at the trailing edge. It was verified that the addition of an extension plate effectively brings about an increase of maximum lift coefficient and an improved lift-to-drag ratio for the Göttingen aerofoil section. However, the effect of the extension plate was small on the Wortmann aerofoil section.
Small amplitude liquid oscillations in a rectangular container under zero-gravity
Authors: Bauer H. F. , Eidel W.
Published: March 2023

Under zero-gravity conditions, the liquid surface in a container has a displaced equilibrium position due to surface tension effects; this depends upon the magnitude of the contact angle to the wall. Free and forced sloshing have been investigated for these conditions. It was found that the natural frequencies of the liquid increases with the contact angle to a maximum value at a contact angle slightly above π/2 and then decreases. This behaviour is not symmetrical within the wetting and non-wetting range. Thus, a completely non-wetting liquid has larger natural frequencies than a completely wetting liquid. It was also found that the sloshing mass of a wetting liquid is considerably larger under zero-gravity than under normal gravity conditions and that a non-wetting liquid exhibits substantially reduced sloshing mass, indicating that the influence of liquids with a small contact angle on the dynamics of a vehicle with liquid containers (with a free liquid surface) may be quite pronounced.
Diminished prospective mental representations of reward mediate reward learning strategies among youth with internalizing symptoms
Authors: Cisler Josh M. , Tamman Amanda J. F. , Fonzo Greg A.
Published: March 2023

Background

Adolescent internalizing symptoms and trauma exposure have been linked with altered reward learning processes and decreased ventral striatal responses to rewarding cues. Recent computational work on decision-making highlights an important role for prospective representations of the imagined outcomes of different choices. This study tested whether internalizing symptoms and trauma exposure among youth impact the generation of prospective reward representations during decision-making and potentially mediate altered behavioral strategies during reward learning.

Methods

Sixty-one adolescent females with varying exposure to interpersonal violence exposure (n = 31 with histories of physical or sexual assault) and severity of internalizing symptoms completed a social reward learning task during fMRI. Multivariate pattern analyses (MVPA) were used to decode neural reward representations at the time of choice.

Results

MVPA demonstrated that rewarding outcomes could accurately be decoded within several large-scale distributed networks (e.g. frontoparietal and striatum networks), that these reward representations were reactivated prospectively at the time of choice in proportion to the expected probability of receiving reward, and that youth with behavioral strategies that favored exploiting high reward options demonstrated greater prospective generation of reward representations. Youth internalizing symptoms, but not trauma exposure characteristics, were negatively associated with both the behavioral strategy of exploiting high reward options as well as the prospective generation of reward representations in the striatum.

Conclusions

These data suggest diminished prospective mental simulation of reward as a mechanism of altered reward learning strategies among youth with internalizing symptoms.
Greek Standardization of the Situational Triggers of Aggressive Responses (STARGR)
Authors: Mylonas Kostas , Lawrence Claire , Frangistas Ioannis , Russa Mary Bower , Papazoglou Sofia , Papachristou Ioanna , Zajenkowska Anna
Published: March 2023

Abstract: Aggressive traits and situational factors interact to influence the propensity for aggressive behavior. Individuals’ sensitivity to the situational factors' provocation and frustration are assessed by the Situational Triggers of Aggressive Responses (STAR) scale subscales sensitivity to provocation (SP) and sensitivity to frustration (SF). The aims of this paper were to (1) briefly summarize the basic theory supporting the STAR scale, (2) review previous cross-cultural findings for these STAR constructs, (3) discuss the Greek factorial structure and its cross-cultural validity, (4) describe the methodological-statistical and psychometric properties for a Greek normative sample ( N = 1,094), and (5) provide Greek norms and other application aspects regarding the STAR scale. The aforementioned are discussed in the context of both a broader methodological-statistical scope and an applied scope. Finally, and with respect to psychological intervention, a method that can be applied to any sample, independently of the existence of norms, is discussed, for multivariately identifying extreme SP and SF cases (outliers).
On‐Line Warning System for Pipe Burst Using Bayesian Dynamic Linear Models
Authors: Henriques‐Silva Renato , Duchesne Sophie , St‐Gelais Nicolas Fortin , Saran Naysan , Schmidt Alexandra M.
Published: March 2023

Pipe breaks are a recurrent problem in water distribution networks and detecting them quickly is crucial to minimize the economic and environmental costs for municipalities. This study presents a burst detection methodology applying Bayesian dynamic linear models (DLMs) on water flow time series combined with an outlier monitoring tool. The model is used to characterize the actual flow and, for each time, a one‐step ahead forecast distribution is obtained recursively before moving onto the next observation. The outlier detection method consists of comparing the main model with an alternative one wherein the mean flow is shifted to a higher value (as bursts tend to increase flow) to evaluate which model best fit the observed data. If the alternative model is favored, a burst alarm is issued. To verify the performance of this approach, the DLM and monitoring tool were applied on 2 yr of flow data from two district meter areas (DMAs) in Halifax (Canada), and a historical break data set is used to assess model accuracy. The model was able to detect up to 75% and 71.2% of the pipe breaks, with a false alarm rate of 5.15% and 12% in the first and second DMA, respectively. Finally, the proposed model allows for straightforward interpretation of model parameters, nonlinear relationship between flow and predictors of interest, naturally describes the uncertainty for future predictions, can easily accommodate missing values and can be tuned to maximize break detection or minimize false alarm rates to adapt to specific objectives of water infrastructure managers.
Earth Mantle's Isotopic Record of Progressive Chemical Depletion
Authors: Sani C. , Sanfilippo A. , Peyve A. A. , Genske F. , Stracke A.
Published: March 2023

Mid ocean ridge basalts are partial melts of mantle rocks that have become incompatible element depleted prior to recent sub‐ridge melting. This prior extent of melt extraction and concomitant incompatible element depletion is often inferred from the radiogenic isotope ratios of ridge basalts, such as hafnium and neodymium. However, hafnium isotope ratios by far exceeding those in ridge basalts are observed sporadically in exposed mantle rocks, abyssal peridotites. At least locally, therefore, Earth's mantle has evolved with much larger extents of incompatible element depletion over geologic time periods (108–109 years) than inferred from ridge basalts. Here we show that such “ultra‐depleted” hafnium isotope signatures also characterize peridotites exposed at the Doldrums Fracture Zone in the equatorial Mid Atlantic. These peridotites are closely associated with peridotites characterized by hafnium‐neodymium isotope ratios similar to ridge basalts, but extensive incompatible element depletion. Our results demonstrate that Earth mantle's isotopic record of prior melt extraction is dampened by ubiquitous past and recent reaction with migrating melts. Hence, a better understanding of chemically reactive flow is required for deducing the mantle's rate of incompatible element depletion by recurring processing through melting regions in the shallow mantle, which is the driving force for silicate Earth evolution. Ultimately, better constraining the rate of incompatible element depletion from Earth's mantle is therefore of first‐order importance for understanding our planet's basic mode of operation.
Excitation of Saturnian ECH Waves Within Remote Plasma Injections: Cassini Observations
Authors: Long Minyi , Cao Xing , Gu Xudong , Ni Binbin , Qu Shaojie , Lou Yuequn , Lai Hairong , Ye Shengyi , Wu Siyuan , Zhao Yiwen
Published: March 2023

Based on Cassini observations, we report representative electrostatic electron cyclotron harmonic (ECH) wave events observed in Saturn's magnetosphere within remote plasma injections. Unlike local injections, remote injections are “older” injection events that have evolved to form a dispersed signature in particle energy spectrum. We show that Saturnian ECH waves within remote injections present a strong fundamental band and much weaker high harmonic bands. By calculating the linear wave growth rates based on the measured electron velocity distributions, we indicate that Saturnian ECH waves can be excited by the loss cone distribution of remotely injected, hot electrons of ∼100 eV to several keV. We find that ECH waves tend to intensify with increased fluxes of injected hot electrons but weakening with increased evolution time of the flux tubes, which is consistent with the results of wave growth rates and improves the current understanding of the generation of ECH waves at Saturn.
Compositional Variations in Sedimentary Deposits in Gale Crater as Observed by ChemCam Passive and Active Spectra
Authors: Manelski H. T. , Sheppard R. Y. , Fraeman A. A. , Wiens R. C. , Johnson J. R. , Rampe E. B. , Frydenvang J. , Lanza N. L. , Gasnault O.
Published: March 2023

During the first 2934 sols of the Curiosity rover's mission 33,468 passive visible/near‐infrared (NIR) reflectance spectra were taken of the surface by the mast‐mounted Chemistry and Camera (ChemCam) instrument on a range of target types. ChemCam spectra of bedrock targets from the Murray and Carolyn Shoemaker formations on Mt. Sharp were investigated using principal component analysis and various spectral parameters including the band depth at 535 nm and the slope between 840 and 750 nm. Four end‐member spectra were identified. Passive spectra were compared to Laser Induced Breakdown Spectroscopy (LIBS) data to search for correlations between spectral properties and elemental abundances. The correlation coefficient between FeOT reported by LIBS and BD535 from passive spectra was used to search for regions where iron may have been added to the bedrock through oxidation of ferrous‐bearing fluids but no correlations were found. Rocks in the Blunts Point‐Sutton Island transition that have unique spectral properties compared to surrounding rocks, that is flat NIR slopes and weak 535 nm absorptions, are associated with higher Mn and Mg in the LIBS spectra of bedrock. Additionally, calcium‐sulfate cements, previously identified by Ca and S enrichments in the LIBS spectra of bedrock, were also shown to be associated with spectral trends seen in Blunts Point. A shift toward a steeper NIR slope is seen in the Hutton interval, indicative of changing depositional conditions or increased diagenesis.
Substorm Induced Nighttime Plasma Flow Pulsations Observed by ROCSAT‐1 at Topside Ionosphere
Authors: Su S.‐Y. , Sun Y.‐Y. , Chao C.‐K. , Tsai L.‐C. , Liu C. H.
Published: March 2023

The Republic of China Satellite‐1 orbiting at 600 km topside ionosphere has observed the topside ionospheric plasma flow pulsations induced by the substorm onsets. These pulsation events indicated that the plasma flow pulsations mainly oscillate in the two mutually perpendicular directions with respect to the geomagnetic field lines. The field‐aligned flow as well as the ion density indicates almost no variation. This implies that the pulsation events are of Alfven wave in nature. The Hilbert‐Huang transform analysis is applied to study the dominant wave frequencies and the polarization in the two perpendicular components of plasma flows (i.e., the perturbed electric/magnetic fields). The hodograms of the polarization in the Pi1 frequency is shown to be linearly polarized, while the left‐handed polarization is seen in the Pi2 frequencies that are in harmonic relationship. These plasma flow pulsations in the nighttime topside ionosphere are caused by the field‐line‐resonance magnetic field pulsations converted from the inward propagated compressional disturbance across the nighttime magnetosphere/plasmasphere which is originated at the near‐Earth magnetotail at the substorm onset.
Hankel Spectrum Analysis: A Decomposition Method for Quasi‐Periodic Signals and Its Geophysical Applications
Authors: Shi Kunpeng , Ding Hao
Published: March 2023

To analyze quasi‐periodic signals (with time‐varying complex amplitudes/frequencies) typically contained in geophysical observables is a quest that has seen continual advances in numerical techniques over the decades. In this study, based on transient z‐pole estimation (in Hankel matrices), a state‐space analysis referred to as Hankel Spectral Analysis (HSA) was developed. Based on the Hankel total least squares and incorporating truncated singular value decomposition and its shift‐invariant property, the HSA aims to decompose the closely spaced sinusoids robustly and orthogonally. Upon using a sliding windows process, the HSA can be used for decomposing and analyzing quasi‐periodic signals, in the support of consecutive parameter spectra {Ai, fi, θi}. Based on a series of experiments, we first confirmed the superiority of the HSA for decomposing different signal constituents (e.g., amplitude‐frequency modulation, mutation, and episodic signals). In real applications, as examples, we use HSA to analyze the polar motion (PM) and Earth's dynamic oblateness (ΔJ2). For the PM, we obtained the time‐varying Chandler wobble (CW) and Annual wobble, and first confirmed that there are four phase jumps in the CW since the 1900s; we find that all of those phase jumps are synchronized by the sharp decrease of Chandler intensity and period, and their random excitation mechanism was discussed. For the ΔJ2, the 18.6 and 10.5 years signals were re‐extracted, and we found that its interannual‐to‐decadal oscillations contribute to multiple global gravity anomalies. These results indicate the great potential of the HSA in decomposing and extracting the recorded periodic/quasi‐periodic signals from geophysical observations.
Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs
Authors: Roseberry K. , Le-Niculescu H. , Levey D. F. , Bhagar R. , Soe K. , Rogers J. , Palkowitz S. , Pina N. , Anastasiadis W. A. , Gill S. S. , Kurian S. M. , Shekhar A. , Niculescu A. B.
Published: March 2023

Anxiety disorders are increasingly prevalent, affect people’s ability to do things, and decrease quality of life. Due to lack of objective tests, they are underdiagnosed and sub-optimally treated, resulting in adverse life events and/or addictions. We endeavored to discover blood biomarkers for anxiety, using a four-step approach. First, we used a longitudinal within-subject design in individuals with psychiatric disorders to discover blood gene expression changes between self-reported low anxiety and high anxiety states. Second, we prioritized the list of candidate biomarkers with a Convergent Functional Genomics approach using other evidence in the field. Third, we validated our top biomarkers from discovery and prioritization in an independent cohort of psychiatric subjects with clinically severe anxiety. Fourth, we tested these candidate biomarkers for clinical utility, i.e. ability to predict anxiety severity state, and future clinical worsening (hospitalizations with anxiety as a contributory cause), in another independent cohort of psychiatric subjects. We showed increased accuracy of individual biomarkers with a personalized approach, by gender and diagnosis, particularly in women. The biomarkers with the best overall evidence were GAD1, NTRK3, ADRA2A, FZD10, GRK4, and SLC6A4. Finally, we identified which of our biomarkers are targets of existing drugs (such as a valproate, omega-3 fatty acids, fluoxetine, lithium, sertraline, benzodiazepines, and ketamine), and thus can be used to match patients to medications and measure response to treatment. We also used our biomarker gene expression signature to identify drugs that could be repurposed for treating anxiety, such as estradiol, pirenperone, loperamide, and disopyramide. Given the detrimental impact of untreated anxiety, the current lack of objective measures to guide treatment, and the addiction potential of existing benzodiazepines-based anxiety medications, there is a urgent need for more precise and personalized approaches like the one we developed.
Transposable elements activation triggers necroptosis in mouse embryonic stem cells
Authors: Jin Lingmei , He Jiangping , Feng Huijian , Li Sa , Liu He , Dong Hongzhi , Hu MingLi , Huang Junju , Wu Haoyu , Chen Jiekai , Qi Ling , Wu Kaixin
Published: March 2023

Deficiency of the histone H3K9 methyltransferase SETDB1 induces RIPK3-dependent necroptosis in mouse embryonic stem cells (mESCs). However, how necroptosis pathway is activated in this process remains elusive. Here we report that the reactivation of transposable elements (TEs) upon SETDB1 knockout is responsible for the RIPK3 regulation through both cis and trans mechanisms. IAPLTR2_Mm and MMERVK10c-int, both of which are suppressed by SETDB1-dependent H3K9me3, act as enhancer-like cis-regulatory elements and their RIPK3 nearby members enhance RIPK3 expression when SETDB1 is knockout. Moreover, reactivated endogenous retroviruses generate excessive viral mimicry, which promotes necroptosis mainly through Z-DNA-binding protein 1 (ZBP1). These results indicate TEs play an important role in regulating necroptosis.