bluuebunny/crossref_metadata_2025 huggingface dataset:
Table S4 from Early-Stage Breast Cancer Detection in Breast Milk
Authors: Saura Cristina , Ortiz Carolina , Matito Judit , Arenas Enrique J. , Suñol Anna , Martín Ágatha , Córdoba Octavi , Martínez-Sabadell Alex , García-Ruiz Itziar , Miranda Ignacio , Morales-Comas Clara , Carrasco Estela , Viaplana Cristina , Peg Vicente , Nuciforo Paolo , Bayó-Puxan Neus , Gonzalez-Medina Alberto , Miquel Josep M. , Gómez-Rey Marina , Villacampa Guillermo , Arévalo Silvia , Espinosa-Bravo Martín , Balmaña Judith , Dienstmann Rodrigo , Arribas Joaquin , Tabernero Josep , Vivancos Ana , Sansó Miriam
Published: October 2023

List of BM samples
Table S3 from Early-Stage Breast Cancer Detection in Breast Milk
Authors: Saura Cristina , Ortiz Carolina , Matito Judit , Arenas Enrique J. , Suñol Anna , Martín Ágatha , Córdoba Octavi , Martínez-Sabadell Alex , García-Ruiz Itziar , Miranda Ignacio , Morales-Comas Clara , Carrasco Estela , Viaplana Cristina , Peg Vicente , Nuciforo Paolo , Bayó-Puxan Neus , Gonzalez-Medina Alberto , Miquel Josep M. , Gómez-Rey Marina , Villacampa Guillermo , Arévalo Silvia , Espinosa-Bravo Martín , Balmaña Judith , Dienstmann Rodrigo , Arribas Joaquin , Tabernero Josep , Vivancos Ana , Sansó Miriam
Published: October 2023

Complete information of the Case cohort, with clinical features and results from the somatic mutation analysis
Table S1 from Early-Stage Breast Cancer Detection in Breast Milk
Authors: Saura Cristina , Ortiz Carolina , Matito Judit , Arenas Enrique J. , Suñol Anna , Martín Ágatha , Córdoba Octavi , Martínez-Sabadell Alex , García-Ruiz Itziar , Miranda Ignacio , Morales-Comas Clara , Carrasco Estela , Viaplana Cristina , Peg Vicente , Nuciforo Paolo , Bayó-Puxan Neus , Gonzalez-Medina Alberto , Miquel Josep M. , Gómez-Rey Marina , Villacampa Guillermo , Arévalo Silvia , Espinosa-Bravo Martín , Balmaña Judith , Dienstmann Rodrigo , Arribas Joaquin , Tabernero Josep , Vivancos Ana , Sansó Miriam
Published: October 2023

VHIO-300 NGS panel gene list
Supplementary Excel Tables from Early-Stage Breast Cancer Detection in Breast Milk
Authors: Saura Cristina , Ortiz Carolina , Matito Judit , Arenas Enrique J. , Suñol Anna , Martín Ágatha , Córdoba Octavi , Martínez-Sabadell Alex , García-Ruiz Itziar , Miranda Ignacio , Morales-Comas Clara , Carrasco Estela , Viaplana Cristina , Peg Vicente , Nuciforo Paolo , Bayó-Puxan Neus , Gonzalez-Medina Alberto , Miquel Josep M. , Gómez-Rey Marina , Villacampa Guillermo , Arévalo Silvia , Espinosa-Bravo Martín , Balmaña Judith , Dienstmann Rodrigo , Arribas Joaquin , Tabernero Josep , Vivancos Ana , Sansó Miriam
Published: October 2023

Table 1. Samples analyzed by NGS
Table 2. VHIO-300 results from solid tumor
Table 3. VHIO-YWBC results from BM positive for ctDNA
Figure S7 from Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity
Authors: Guirguis Andrew A. , Ofir-Rosenfeld Yaara , Knezevic Kathy , Blackaby Wesley , Hardick David , Chan Yih-Chih , Motazedian Ali , Gillespie Andrea , Vassiliadis Dane , Lam Enid Y.N. , Tran Kevin , Andrews Byron , Harbour Michael E. , Vasiliauskaite Lina , Saunders Claire J. , Tsagkogeorga Georgia , Azevedo Aleksandra , Obacz Joanna , Pilka Ewa S. , Carkill Marie , MacPherson Laura , Wainwright Elanor N. , Liddicoat Brian , Blyth Benjamin J. , Albertella Mark R. , Rausch Oliver , Dawson Mark A.
Published: October 2023

A20 lymphoma model data
Figure S6 from Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity
Authors: Guirguis Andrew A. , Ofir-Rosenfeld Yaara , Knezevic Kathy , Blackaby Wesley , Hardick David , Chan Yih-Chih , Motazedian Ali , Gillespie Andrea , Vassiliadis Dane , Lam Enid Y.N. , Tran Kevin , Andrews Byron , Harbour Michael E. , Vasiliauskaite Lina , Saunders Claire J. , Tsagkogeorga Georgia , Azevedo Aleksandra , Obacz Joanna , Pilka Ewa S. , Carkill Marie , MacPherson Laura , Wainwright Elanor N. , Liddicoat Brian , Blyth Benjamin J. , Albertella Mark R. , Rausch Oliver , Dawson Mark A.
Published: October 2023

PDL1 expression + STM3006 pharmacokinetic studies
Figure S2 from Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity
Authors: Guirguis Andrew A. , Ofir-Rosenfeld Yaara , Knezevic Kathy , Blackaby Wesley , Hardick David , Chan Yih-Chih , Motazedian Ali , Gillespie Andrea , Vassiliadis Dane , Lam Enid Y.N. , Tran Kevin , Andrews Byron , Harbour Michael E. , Vasiliauskaite Lina , Saunders Claire J. , Tsagkogeorga Georgia , Azevedo Aleksandra , Obacz Joanna , Pilka Ewa S. , Carkill Marie , MacPherson Laura , Wainwright Elanor N. , Liddicoat Brian , Blyth Benjamin J. , Albertella Mark R. , Rausch Oliver , Dawson Mark A.
Published: October 2023

Gene expression changes + pathways
Figure S1 from Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity
Authors: Guirguis Andrew A. , Ofir-Rosenfeld Yaara , Knezevic Kathy , Blackaby Wesley , Hardick David , Chan Yih-Chih , Motazedian Ali , Gillespie Andrea , Vassiliadis Dane , Lam Enid Y.N. , Tran Kevin , Andrews Byron , Harbour Michael E. , Vasiliauskaite Lina , Saunders Claire J. , Tsagkogeorga Georgia , Azevedo Aleksandra , Obacz Joanna , Pilka Ewa S. , Carkill Marie , MacPherson Laura , Wainwright Elanor N. , Liddicoat Brian , Blyth Benjamin J. , Albertella Mark R. , Rausch Oliver , Dawson Mark A.
Published: October 2023

Proliferation + Apoptosis assays
Supplementary Tables 1-12 from Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses
Authors: Farin Henner F. , Mosa Mohammed H. , Ndreshkjana Benardina , Grebbin Britta M. , Ritter Birgit , Menche Constantin , Kennel Kilian B. , Ziegler Paul K. , Szabó Lili , Bollrath Julia , Rieder Dietmar , Michels Birgitta E. , Kress Alena , Bozlar Müge , Darvishi Tahmineh , Stier Sara , Kur Ivan-Maximilano , Bankov Katrin , Kesselring Rebecca , Fichtner-Feigl Stefan , Brüne Bernhard , Goetze Thorsten O. , Al-Batran Salah-Eddin , Brandts Christian H. , Bechstein Wolf O. , Wild Peter J. , Weigert Andreas , Müller Susanne , Knapp Stefan , Trajanoski Zlatko , Greten Florian R.
Published: October 2023

Supplementary Table S1 shows the clinical data of the CRC organoid-stroma cohort.
Supplementary Table S2 shows the inventory of available materials and molecular analyses.
Supplementary Table S3 shows the selected variant types for whole exome analysis.
Supplementary Table S4 summarizes the genetic characterization of CRC models.
Supplementary Table S5 shows the classification according to the consensus molecular subtypes (CMS).
Supplementary Table S6 shows classification according to the CRC intrinsic subtypes (CRIS).
Supplementary Table S7 summarizes the functional data in mono- and co-cultures.
Supplementary Table S8 shows drug sensitivity of CRC organoids in co-culture with autologous and heterologous fibroblasts.
Supplementary Table S9 show the drug sensitivity in all biobank models in mono- and co-culture.
Supplementary Table S10 shows the cell viability data of the chemogenomic library screens in resistant co-culture models.
Supplementary Table S11 shows the identified drug sensitivity and resistance signatures.
Supplementary Table S12 lists all antibodies and primer sequences used in this study.
Supplementary Table S5 from An Inflammatory Checkpoint Generated by IL1RN Splicing Offers Therapeutic Opportunity for KRAS-Mutant Intrahepatic Cholangiocarcinoma
Authors: Zhang Mao , Huang Yingying , Pan Jiaomeng , Sang Chen , Lin Youpei , Dong Liangqing , Shen Xia , Wu Yingcheng , Song Guohe , Ji Shuyi , Liu Fen , Wang Mengcheng , Zheng Yuyan , Zhang Sirui , Wang Zefeng , Ren Jianke , Gao Daming , Zhou Jian , Fan Jia , Wei Wu , Lin Jian , Gao Qiang
Published: October 2023

Supplementary Table S5. Top 200 genes for each T cell cluster obtained by wilcox test with the rank_genes_groups function in Scanpy.
Data from The origin of highly elevated cell-free DNA in healthy individuals and patients with pancreatic, colorectal, lung, or ovarian cancer
Authors: Mattox Austin K. , Douville Christopher , Wang Yuxuan , Popoli Maria , Ptak Janine , Silliman Natalie , Dobbyn Lisa , Schaefer Joy , Lu Steve , Pearlman Alexander H. , Cohen Joshua D. , Tie Jeanne , Gibbs Peter , Lahouel Kamel , Bettegowda Chetan , Hruban Ralph H. , Tomasetti Cristian , Jiang Peiyong , Chan K.C. Allen , Lo Yuk Ming Dennis , Papadopoulos Nickolas , Kinzler Kenneth W. , Vogelstein Bert
Published: October 2023

Abstract
cfDNA concentrations from patients with cancer are often elevated compared to that of healthy controls, but the sources of this extra cfDNA have never been determined. To address this issue, we assessed cfDNA methylation patterns in 178 patients with cancers of the colon, pancreas, lung, or ovary and 64 patients without cancer. Eighty-three of these individuals had cfDNA concentrations much greater than those generally observed in healthy subjects. The major contributor of cfDNA in all samples was leukocytes, accounting for ~76% of cfDNA, with neutrophils predominating. This was true regardless of whether the samples were derived from patients with cancer or the total plasma cfDNA concentration. High levels of cfDNA observed in patients with cancer did not come from either neoplastic cells or from surrounding normal epithelial cells from the tumor's tissue of origin. These data suggest that cancers may have a systemic effect on cell turnover or DNA clearance.
Data from The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer
Authors: Mattox Austin K. , Douville Christopher , Wang Yuxuan , Popoli Maria , Ptak Janine , Silliman Natalie , Dobbyn Lisa , Schaefer Joy , Lu Steve , Pearlman Alexander H. , Cohen Joshua D. , Tie Jeanne , Gibbs Peter , Lahouel Kamel , Bettegowda Chetan , Hruban Ralph H. , Tomasetti Cristian , Jiang Peiyong , Chan K.C. Allen , Lo Yuk Ming Dennis , Papadopoulos Nickolas , Kinzler Kenneth W. , Vogelstein Bert
Published: October 2023

Abstract
Cell-free DNA (cfDNA) concentrations from patients with cancer are often elevated compared with those of healthy controls, but the sources of this extra cfDNA have never been determined. To address this issue, we assessed cfDNA methylation patterns in 178 patients with cancers of the colon, pancreas, lung, or ovary and 64 patients without cancer. Eighty-three of these individuals had cfDNA concentrations much greater than those generally observed in healthy subjects. The major contributor of cfDNA in all samples was leukocytes, accounting for ∼76% of cfDNA, with neutrophils predominating. This was true regardless of whether the samples were derived from patients with cancer or the total plasma cfDNA concentration. High levels of cfDNA observed in patients with cancer did not come from either neoplastic cells or surrounding normal epithelial cells from the tumor's tissue of origin. These data suggest that cancers may have a systemic effect on cell turnover or DNA clearance.
Significance:
The origin of excess cfDNA in patients with cancer is unknown. Using cfDNA methylation patterns, we determined that neither the tumor nor the surrounding normal tissue contributes this excess cfDNA—rather it comes from leukocytes. This finding suggests that cancers have a systemic impact on cell turnover or DNA clearance.

See related commentary by Thierry and Pisareva, p. 2122.

This article is featured in Selected Articles from This Issue, p. 2109
Data from An inflammatory checkpoint generated by IL1RN splicing offers therapeutic opportunity for KRAS mutant intrahepatic cholangiocarcinoma
Authors: Zhang Mao , Huang Yingying , Pan Jiaomeng , Sang Chen , Lin Youpei , Dong Liangqing , Shen Xia , Wu Yingcheng , Song Guohe , Ji Shuyi , Liu Fen , Wang Mengcheng , Zheng Yuyan , Zhang Sirui , Wang Zefeng , Ren Jianke , Gao Daming , Zhou Jian , Fan Jia , Wei Wu , Lin Jian , Gao Qiang
Published: October 2023

Abstract
KRAS mutations are causally linked to pro-tumor inflammation and identified as driving factors in tumorigenesis. Here, using multi-omics data gathered from a large set of patients, we showed that KRAS mutation was associated with a specific landscape of alternative mRNA splicing that connected to myeloid inflammation in intrahepatic cholangiocarcinoma (iCCA). Then, we identified a negative feedback mechanism in which the upregulation of interleukin 1 receptor antagonist (IL1RN)-201/203 due to alternative splicing confers vital anti-inflammatory effects in KRAS mutant iCCA. In KRAS mutant iCCA mice, both IL1RN-201/203 upregulation and anakinra treatment ignited a significant anti-tumor immune response by altering neutrophil recruitment and phenotypes. Furthermore, anakinra treatment synergistically enhanced anti-PD-1 therapy to activate intratumoral GZMB+ CD8+ T cells in KRAS mutant iCCA mice. Clinically, we found that high IL1RN-201/203 levels in KRAS mutant iCCA patients were significantly associated with superior response to anti-PD-1 immunotherapy.
Data from An Inflammatory Checkpoint Generated by IL1RN Splicing Offers Therapeutic Opportunity for KRAS-Mutant Intrahepatic Cholangiocarcinoma
Authors: Zhang Mao , Huang Yingying , Pan Jiaomeng , Sang Chen , Lin Youpei , Dong Liangqing , Shen Xia , Wu Yingcheng , Song Guohe , Ji Shuyi , Liu Fen , Wang Mengcheng , Zheng Yuyan , Zhang Sirui , Wang Zefeng , Ren Jianke , Gao Daming , Zhou Jian , Fan Jia , Wei Wu , Lin Jian , Gao Qiang
Published: October 2023

Abstract
KRAS mutations are causally linked to protumor inflammation and are identified as driving factors in tumorigenesis. Here, using multiomics data gathered from a large set of patients, we showed that KRAS mutation was associated with a specific landscape of alternative mRNA splicing that connected to myeloid inflammation in intrahepatic cholangiocarcinoma (iCCA). Then, we identified a negative feedback mechanism in which the upregulation of interleukin 1 receptor antagonist (IL1RN)-201/203 due to alternative splicing confers vital anti-inflammatory effects in KRAS-mutant iCCA. In KRAS-mutant iCCA mice, both IL1RN-201/203 upregulation and anakinra treatment ignited a significant antitumor immune response by altering neutrophil recruitment and phenotypes. Furthermore, anakinra treatment synergistically enhanced anti–PD-1 therapy to activate intratumoral GZMB+ CD8+ T cells in KRAS-mutant iCCA mice. Clinically, we found that high IL1RN-201/203 levels in patients with KRAS-mutant iCCA were significantly associated with superior response to anti–PD-1 immunotherapy.
Significance:
This work describes a novel inflammatory checkpoint mediated by IL1RN alternative splicing variants that may serve as a promising basis to develop therapeutic options for KRAS-mutant iCCA and other cancers.

This article is featured in Selected Articles from This Issue, p. 2109
TABLE 2 from Chromatin Accessibility Landscape of Human Triple-negative Breast Cancer Cell Lines Reveals Variation by Patient Donor Ancestry
Authors: Harris Alexandra R. , Panigrahi Gatikrushna , Liu Huaitian , Koparde Vishal N. , Bailey-Whyte Maeve , Dorsey Tiffany H. , Yates Clayton C. , Ambs Stefan
Published: October 2023

Upstream regulator analysis of TCGA breast cancer data identifies patient group-associated TFs that have a common association with ATAC-seq signals in the TNBC human cell lines
TABLE 1 from Chromatin Accessibility Landscape of Human Triple-negative Breast Cancer Cell Lines Reveals Variation by Patient Donor Ancestry
Authors: Harris Alexandra R. , Panigrahi Gatikrushna , Liu Huaitian , Koparde Vishal N. , Bailey-Whyte Maeve , Dorsey Tiffany H. , Yates Clayton C. , Ambs Stefan
Published: October 2023

TNBC cell lines derived from women of EA and AA descent
Supplementary Table 7 from Chromatin Accessibility Landscape of Human Triple-negative Breast Cancer Cell Lines Reveals Variation by Patient Donor Ancestry
Authors: Harris Alexandra R. , Panigrahi Gatikrushna , Liu Huaitian , Koparde Vishal N. , Bailey-Whyte Maeve , Dorsey Tiffany H. , Yates Clayton C. , Ambs Stefan
Published: October 2023

Supplementary table 7 displaying data output from digital footprinting analysis performed on ATAC-seq data from TNBC cell lines cultured under hypoxia.
FIGURE 4 from Chromatin Accessibility Landscape of Human Triple-negative Breast Cancer Cell Lines Reveals Variation by Patient Donor Ancestry
Authors: Harris Alexandra R. , Panigrahi Gatikrushna , Liu Huaitian , Koparde Vishal N. , Bailey-Whyte Maeve , Dorsey Tiffany H. , Yates Clayton C. , Ambs Stefan
Published: October 2023

Hypoxia exacerbates donor ancestry-related differences in TF activity in cultured TNBC cell lines. A, Chromosome map showing the distribution of DARs between EA and AA TNBC cells when subjected to hypoxic conditions (FC > 2, FDR < 0.01). B, Differential digital footprinting in EA- and AA-derived TNBC lines was performed using TOBIAS to identify open chromatin regions and their TF binding sites. Shown are the top AA- or EA-associated TFs whose predicted binding activity increased by a defined magnitude of >0.05 under hypoxia. PPI network of TFs with differential binding capacities (DBS > 22.5, FDR < 0.01) that are up in EA (C) and AA (D) under hypoxia using the STRING database. Top 15 significantly enriched pathways (FDR < 0.01, Reactome-based) based on a TF network analysis.
Functional Lesion Network Mapping of Sensory Deficits After Ischemic Stroke
Authors: Schlemm Eckhard , Cheng Bastian , Thomalla Götz , Kessner Simon S.
Published: October 2023

BACKGROUND:

Sensory deficits are common after stroke, leading to disability and poor quality of life. Although lesion locations and patterns of structural brain network disruption have been associated with sensory disturbances, the relation with functional lesion connectivity has not yet been established.

METHODS:

Retrospective analysis of a prospective cohort study of patients with acute ischemic stroke. Indirect functional lesion network mapping to identify brain regions remote from the primary lesion associated with deficits on the Rivermead Assessment of Somatosensory Performance test. Associations between Rivermead Assessment of Somatosensory Performance scores and functional connectivity of the lesion site with prespecified components of the somatosensory system.

RESULTS:

One hundred one patients (mean age, 62 years; 32% women) from the TOPOS study (Topological and Clinical Prospective Study About Somatosensation in Stroke). Lesion network mapping identified a bilateral fronto-parietal network associated with sensory deficits in the acute phase after stroke. There were graded associations between deficits and functional lesion connectivity to sensory cortices, but not the thalamus.

CONCLUSIONS:

Infarcts in brain regions remote from, but functionally connected, to the somatosensory network are associated with somatosensory deficits measured by the Rivermead Assessment of Somatosensory Performance test, reflecting the hierarchical functional anatomy of sensory processing. Further research is needed to translate these findings into improved prognosis and personalized rehabilitation strategies.
Introduction: Pragmatism, Dewey, and Design Inquiry
Authors: Dixon Brian , Eklund Anna Rylander , Wegener Frithjof
Published: October 2023

This article introduces the special issue on Design Pragmatism and Design Inquiry by drawing attention to the key design-orientated principles found in pragmatism, detailing the content of the articles and, from this, mapping the direction for future research.
Left-Hemisphere Cortical Language Regions Respond Equally to Observed Dialogue and Monologue
Authors: Olson Halie A. , Chen Emily M. , Lydic Kirsten O. , Saxe Rebecca R.
Published: October 2023

Much of the language we encounter in our everyday lives comes in the form of conversation, yet the majority of research on the neural basis of language comprehension has used input from only one speaker at a time. Twenty adults were scanned while passively observing audiovisual conversations using functional magnetic resonance imaging. In a block-design task, participants watched 20 s videos of puppets speaking either to another puppet (the dialogue condition) or directly to the viewer (the monologue condition), while the audio was either comprehensible (played forward) or incomprehensible (played backward). Individually functionally localized left-hemisphere language regions responded more to comprehensible than incomprehensible speech but did not respond differently to dialogue than monologue. In a second task, participants watched videos (1–3 min each) of two puppets conversing with each other, in which one puppet was comprehensible while the other’s speech was reversed. All participants saw the same visual input but were randomly assigned which character’s speech was comprehensible. In left-hemisphere cortical language regions, the time course of activity was correlated only among participants who heard the same character speaking comprehensibly, despite identical visual input across all participants. For comparison, some individually localized theory of mind regions and right-hemisphere homologues of language regions responded more to dialogue than monologue in the first task, and in the second task, activity in some regions was correlated across all participants regardless of which character was speaking comprehensibly. Together, these results suggest that canonical left-hemisphere cortical language regions are not sensitive to differences between observed dialogue and monologue.
‘Spiritual Blindness’ in the Bartimaeus Pericope (Mark 10:46–52): Toward Decentering Ableist Readings
Authors: O’Connor M. John-Patrick
Published: October 2023

It is commonly acknowledged that blindness and seeing play an important role in the theology of the Gospel of Mark. Typically, readers interpret “spiritual blindness” as the moral thrust of the discipleship discourse in Mark 8:22–10:52. While the disciples fail to see their teacher as the Christ, blind Bartimaeus appears to identify Jesus as the “Son of David” (10:46–52). However, centering blindness-as-vice not only plays on an unfortunate ableist binary but also renders Mark’s more marginal characters as insignificant. Research on blindness in antiquity demonstrates how socioeconomic status was a leading factor in determining social perceptions of the blind. This article contends that Mark’s Bartimaeus pericope should be read accordingly. Instead of serving as a metaphor for “spiritual blindness,” physically blind characters are raised to the status of insider as a condemnation of mistreatment of the poor—a motif found within the broader terrain of Mark’s moral landscape (6:30–44; 8:1–10; 12:38–44; 14:1–11).
ʿUmar ii and the Prohibition of Ṭilāʾ and Nabīdh
Authors: Harvey Elon
Published: October 2023

Following a brief introduction, this article has two parts and an appendix. In the first part, I examine the passage prohibiting intoxicating ṭilāʾ (cooked grape juice) in the “fiscal rescript” attributed to ʿUmar ii (d. 101/720) by Ibn ʿAbd al-Ḥakam (d. 214/829). I argue that this passage’s core goes back to an edict of ʿUmar ii that is no longer extant. I suggest that ʿUmar ii issued the prohibition following an earthquake that devastated Syria because he feared that the drinkers of intoxicants would cause a similar catastrophe to befall all Muslims. I situate ʿUmar ii’s prohibition within the early legal discussions about ṭilāʾ. In the second part, I analyze a group of edicts prohibiting nabīdh (date wine) that are attributed to ʿUmar ii. I conclude that the edicts are pseudepigraphical. In the appendix, I trace the transmission history of a tradition attributed to al-Shaʿbī about a missive of Umar I concerning ṭilāʾ.
For the Most Part Serious?
Authors: Kuhn-Treichel Thomas
Published: October 2023

Scholarship has drawn a contrast between modern uses of metalepsis (illogical transgressions of narrative levels), which are frequently assigned comic effects, and their ancient counterparts, which are deemed more serious. This article argues that in the case of authorial metalepsis, a way of expression presenting the narrator as bringing about the effects he describes, the comic potential was already discovered in antiquity. Case studies from Aristophanes, Plato, Horace, Juvenal, Ovid, and Lucian demonstrate how ancient authors use authorial metalepsis to evoke paradoxical scenes of interaction across different levels of representation that support a mocking presentation of other authors.
What Does Not Tremble Is Not Stable: Three Philosophical Streams from the Spring of (Un)Certainty
Authors: Naot Hila
Published: October 2023

The article proposes a phenomenological journey through three concepts of uncertainty – those of Blaise Pascal, Ludwig Wittgenstein, and Jan Patočka. The discussion focuses on the meaning of certainty and uncertainty and on the mutual relations between the two according to each philosopher. Adopting an embodied philosophical-poetic perspective enables the dialectical relations prevailing between these three conceptions to emerge, clarifying that, despite their differences, they share a deep attachment to the transcendent dimension of human existence. This dimension is described as “uncertain certainty,” implying attention to the quiver of absolute meaning dwelling within and beyond the movement of humans and the lifeworld.
The Three “Fundamental Deceptions” of Being and Time: Heidegger’s Phenomenology Revisited
Authors: Abergel David Charles
Published: October 2023

In his private notes written in 1936 (now published as GA82), Heidegger enumerates three “fundamental deceptions” at play in Being and Time (1927). The thrust of these deceptions is twofold: that Dasein is something given and that the task of phenomenology is to describe Dasein in its givenness. These are deceptions, Heidegger claims in 1936, because Dasein is not something given, but can only be reached in a leap, and because the task of phenomenology is not to describe Dasein in its givenness, but to bring about Dasein and the “there,” the site of Being’s happening, through a creative leap-in. Scholars might be inclined to read these deceptions as further evidence for the view that Heidegger in the 1930s abandons phenomenology understood as a descriptive enterprise oriented toward givenness. This paper argues, to the contrary, that phenomenology for the young Heidegger was never a descriptive enterprise oriented toward givenness, but always, however obliquely presented throughout the 1920s, a way of participating in the creative unfolding of the site of Being’s happening.
An Unstudied Interpretation of Ecclesiastes 12:3–6 in Slavonic and Its Context
Authors: Miltenova Anissava , Iliev Ivan I.
Published: October 2023

There is a discussion about the genre labels of Ecclesiastes and some authors consider that the message of the Book is “anti-apocalyptic” (J.N. Douglas 2011). Quotations from the Old Testament Book Ecclesiastes are very rare as a part of the historical and apocalyptic works both in Greek and Old Church Slavonic. For example, it is cited in the Interpretation of the Book of Daniel by Hippolytus of Rome both in the Greek prototype and in the Slavonic translation. An interpretation of Ecclesiastes 12:3–6 has been found in the last folia of a newly discovered manuscript of Russian National Library Q.I.622 (main collection), middle of 15th c. The excerpt is interpreted allegorically and has a typical rhetorical structure for apocalyptic texts. It is interesting not only with arguments for apocalyptic interpretation but also in its language characteristic in comparison with other manuscripts of the Book Ecclesiastes in the translation of Old Church Slavonic. The context of the interpretation also is important concerning the history and transmission of the text, and the understanding of the author’s message in the Slavic milieu.
Decolonization without Self-Determination?
Authors: Feijó Rui Graça , Pereira Zélia
Published: October 2023

As the Carnation Revolution of 25 April 1974 in Lisbon set in motion the process of decolonizing the empire, the future of ‘Portuguese Timor’ was the subject of an intense debate which involved external actors. Like other Asian remnants of the empire, Timor was a small territory surrounded by a giant neighbour, which laid claim to be part of the process. Indonesia sought contact with the Portuguese authorities, and the countries held several rounds of talks up to November 1975. This essay surveys those talks, based primarily on Portuguese archival material, and details how the two countries failed to reach an agreement. Whereas Indonesia sought direct negotiations that would decolonize the territory while excluding the Timorese themselves, Portugal took note of Indonesian claims but insisted that a genuine act of self-determination based on the direct consultation of the Timorese people was required.
Laterality affects coloration in Red Sea Ghost Crabs (Ocypode saratan)
Authors: Yosef Reuven , Curtis Nicole , Kosicki Jakub Z.
Published: October 2023

The ability to change colors or appearance to blend into the background habitat is essential to ensure an individual’s survival. This is especially challenging in a heterogeneous habitat such as the intertidal zone of a seashore, which is the primary habitat of crabs. The Red Sea Ghost Crab (RSGC) is endemic to the Red Sea, and in Israel, it is found only at one beach. We discovered that right-clawed crabs are lighter colored (i.e., yellow, sand) than left-clawed crabs (brown, purple), consistent with their daily activity. The closest to the water were the sand-colored, left-clawed crabs, while the farthest up the beach were the yellow-colored, right-clawed crabs. Moreover, we observed purple-colored, left-clawed crabs during low UV radiation, while during high UV radiation, we observed brown-colored, right-claws crabs. In explaining the observed segregation, we speculate that claw lateralization and body colors are common in the social signaling system. Symmetrically identical individuals can signal their condition to their competitors by colors. However, this part of the signaling is under the pressure of the intensity of sunlight.
Social Protection as Technocratic Fix?: Labour Precarity and Crises of Capitalism after Bangladesh’s Rana Plaza Collapse
Authors: Prentice Rebecca , Sumon Mahmudul H.
Published: October 2023

After the 2013 collapse of Bangladesh’s Rana Plaza garment manufacturing building, the Rana Plaza Arrangement (rpa) provided work-injury compensation benefits to injured survivors and the families of those killed, funded by global apparel brands. This article draws upon qualitative interviews with international stakeholders—including global brands, activists, and the International Labour Organization (ilo)—who developed and implemented the rpa, and survivors who claimed compensation payments. We analyse the rpa as an experiment in transnational social protection, which attempted to recentre labour rights and state responsibility after three decades of neoliberal labour governance. Arguing that social protection can be a technocratic “fix” to restore and make tolerable an injurious economic system, we demonstrate the inherent paradox of attempting to integrate precarious labour into decent and dignified social protection. The rpa’s many failures suggest that state commitment to regulation and organized labour power are necessary ingredients for successful transnational social protection.
From “Green Movement” to “Woman, Life, Freedom”: Continuity and Change in the Evolution of the Protest Movement in Iran
Authors: Khalili Mostafa
Published: October 2023

The “woman, life, freedom” protest movement that started in September 2022 and lasted for several months is arguably the largest set of demonstrations in Iran since the formation of the Islamic Republic. Its most noticeable characteristic compared to the “Green Movement” in 2009, has been the radicalization of slogans and the transformation of the demands from the quest for reform to seeking regime change. This article briefly examines the socio-political processes that triggered the disappointment of the public with top-down reform, resulting in the gradual radicalization of protesters’ demands between those two movements. It is argued that the failure of the reformists to implement sustainable top-down transformation in politics gave rise to the rapid spread of nationwide bottom-up, unorganized forms of resistance. While their forms, aims, and mobilization incentives have been highly diverse, participants converge in perceiving regime change as the only alternative solution.
Innovations amid Gaps between Policy and Practice for Sustainable Development
Authors: Chien Herlin , Lin Shu-ling
Published: October 2023

This study asks under what institutional condition or governance structure might the gap between policy and practice be conducive to innovative practices. It examines how social innovations are formed amid gaps between policy and practice to tame a wicked problem and achieve sustainable development. First, data was gathered during the implementation of a livestock wastewater policy in four municipalities in southern Taiwan where livestock wastewater pollution is rampant and presents a wicked problem. Next, the focus narrowed to the governing network, namely metagovernance, ignoring other factors such as the role of the social entrepreneur. The article argues that the gap between policy and practice can be framed as a window of opportunity, with positive connotations for policy implementation innovation. The authors analyze the empirical and showcase how innovations, represented by the heterogeneity of metagovernance, were generated in a recursive manner amid gaps between policy and practice in different localities.
A new species of the genus Smicromyrme THOMSON, 1870 (Hymenoptera: Mutillidae) from India
Authors: TERINE JOSHUA B. , KUMAR GIRISH P.
Published: October 2023

Smicromyrme (Eremotilla) williamsi Terine & Girish Kumar, sp. nov. is described based on a female specimen from Kerala, Southern India. A modified key to the S. coromandelica species-group (females only) is given.
Collaborative Inquiry for Change and Changing: Advances in Science-Practice Transformations
Authors: Shani Abraham B. (Rami) , Coghlan David , Paine Jill W. , Canterino Filomena
Published: October 2023

The overall context of this special issue is that in this volatile, unpredictable, complex, and ambiguous contemporary world, collaboration between researchers of different disciplines, between researchers and practitioners, and between institutions is imperative. This special issue presents seven papers with different approaches to collaborative inquiry. Each one provides a perspective of the way collaborative inquiry can address multilevel, multistakeholder, and longitudinal change in the current dynamic and constantly changing environment in which organizations reside. Taken together, the contributions in this volume make a powerful statement concerning the emerging significance of the collaborative inquiry paradigm and its potential future.
All-knitted stretchable dipole antenna: design, fabrication, and effects of yarn alignments on antenna electromagnetic and tensile properties
Authors: Kuang Ye , Rui Xue , Lou Lin , Li Lin , Huang Hai-Xin , Ding Xiao-Jun , Yan Yan-Hong , Wang Qing
Published: October 2023

With the evolution of the Internet of Things, stretchable antennas are playing an increasingly important role in wearable devices and flexible electronics. Typical drawbacks of current stretchable antennas are complex manufacturing processes, inadequate ventilation, and limited flexibility, which negatively impact their comfort and practicality. In this study, an all-knitted stretchable dipole antenna was designed and fabricated. This antenna was breathable and flexible like regular knitted fabric and had a simple manufacturing process. In addition, the effects of two yarn alignment types, namely antenna arms aligned in the course (AaC) and wale (AaW) directions, on antenna electromagnetic properties under tensile stress were investigated. Under unstretched conditions, both antenna AaC and AaW exhibited S11 of less than –10 dB at the operating frequency of 915 MHz, demonstrating good impedance matching performance and omnidirectional radiation characteristics. When stretched along the arm length direction, the frequency variations and strain of antenna AaC and AaW displayed strong linear relationships. Specifically, antenna AaC exhibited a higher sensitivity to the resonant frequency variation induced by strain when compared to antenna AaW. The results suggest that the antenna AaC are a more desirable option to be used as a sensor for human body movement monitoring. This study provides the theoretical basis and experimental foundation for the design and large-scale production of stretchable antennas utilizing textile materials.
They Saw a Hearing: Democrats’ and Republicans’ Perceptions of and Responses to the Ford-Kavanaugh Hearings
Authors: Grisham Emma L. , Dashtgard Pasha , Relihan Daniel P. , Holman E. Alison , Silver Roxane Cohen
Published: October 2023

In several highly publicized hearings, Dr. Christine Blasey Ford and Judge Brett Kavanaugh presented two opposing accounts of an alleged sexual assault. In the wake of these proceedings, partisans appeared similarly divided in how they regarded this political event. Using a U.S. national sample ( N = 2,474) and a mixed-methods design, we investigated partisans’ perceptions of, and responses to, the Ford-Kavanaugh hearings. Respondents reported their views of the hearings soon after they occurred. We used topic modeling to analyze these open-ended responses and found uniquely partisan topics emerged, including judicial impartiality and due process. Acute stress (AS) responses to the hearings were also related to partisan identities and perceptions; both Republicans (incidence rate ratio [IRR] = 0.81, 95% confidence interval [CI] = [0.78, 0.84]) and individuals who wrote more about Republican topics (IRR = 0.72, 95% CI = [0.56, 0.92]) reported lower AS than their Democratic counterparts. Results demonstrate different partisan perceptions with implications for mental health outcomes.
Pierre Jurieu and the Creation of a Protestant Imagined Community in England, 1680–1705
Authors: Mitchell William H. F.
Published: October 2023

This article discusses how Pierre Jurieu's (1637–1713) political journalism advanced the cause of pan-Protestantism in the later seventeenth century. It examines how Jurieu portrayed his Huguenot subjects as worthy of sympathy, as well as spelling out how that sympathy could manifest itself politically, by reinterpreting the Glorious Revolution as an event that enabled England to carry out a pan-Protestant foreign policy. This discussion demonstrates how Jurieu was characteristic of three trends that have attracted historiographical attention. Firstly, Jurieu's works were part of the later seventeenth century speeding up of time and closing in of space: he informed his readers of events in faraway regions in unprecedentedly quick time spans. Secondly, the reconstruction of Jurieu's patronage networks in the English print market casts aspersions on the idea of a pristine public sphere. Thirdly, his blending of religious and political ideas problematizes the divide between the two: his apocalyptic writings complemented his works on political economy, and vice versa. With these themes in mind, Jurieu is presented as a provider of one of the richest defences of pan-Protestantism, as well as a representative actor of the broader forces that were shaping English discourse in the later seventeenth century.
Autonomy Over Independence: Self-Determination in Catalonia, Flanders and South Tyrol in the Aftermath of the Great War
Authors: Dalle Mulle Emmanuel , Bieling Mona
Published: October 2023

The end of the First World War was a crucial time for nationalist leaders and minority communities across the European continent and beyond. The impact of the post-war spread of self-determination on the redrawing of Eastern European borders and on the claims of colonial independence movements has been extensively researched. By contrast, the international historiography has paid little attention to minority nationalist movements in Western Europe. This article focuses on three regions (Catalonia, Flanders and South Tyrol) that experienced considerable sub-state national mobilization in the interwar period. We aim to understand whether the leaders of Western European minorities and stateless nations shared the same enthusiasm as their anti-colonial and Eastern European counterparts for the new international order that self-determination seemed to foreshadow in the months following the end of the First World War. Because the American President Woodrow Wilson stood out as the most prominent purveyor of the new international legitimacy of self-determination, the article further examines how Western European nationalist movements exploited Wilson's image and advocacy to achieve their own goals. Nationalist forces in Catalonia, Flanders and South Tyrol initially mobilized self-determination and referred to Wilson as a symbol of national liberation, but this instrumentalization of self-determination was not sustained. Large-scale mobilization occurred only in Catalonia, and, even there, it disappeared suddenly in spring 1919. Furthermore, sub-state nationalist movements in Western Europe tended to mobilize self-determination to gain regional autonomy, rather than full independence, thus pursuing internal, not external, self-determination. The willingness of these movements to privilege autonomy over full independence made them more receptive to compromise. Radical forces would become stronger only in the 1930s and largely for reasons not directly connected to the post-war mobilization around self-determination.
Africa for the Africans? Risorgimento Republicans and Cosmopolitan Nationalists in an Age of Empire
Authors: Moore Diana
Published: October 2023

Within a few decades, the Italian people went from a partially colonized to colonizing power. A number of Italian patriots, therefore, who had espoused the ideals of self-determination, republicanism, and cosmopolitan nationalism, found themselves grappling with the rapid entry into colonization of the nation they had fought so hard to create. This article examines the thoughts and ideas of a select group of these individuals: Aurelio Saffi, Agostino Bertani, Alberto Mario, and Jessie White Mario. Focusing on their arguments in the 1880s and 1890s, it examines their reaction to the establishment of the French protectorate in Tunisia (1881), the British invasion of Egypt and defeat of Ahmad ʿUrabi's seemingly nationalist movement (1882), and the development of the Italian colony in East Africa. Throughout, the article emphasizes the shared importance of the civilizing mission in the ideology of both Italian cosmopolitan nationalism and colonialism. Though left-wing thinkers like Saffi or Bertani fervently argued for the freedom of nationalities and a brotherhood of peoples, their belief that a people needed to be sufficiently advanced for self-government, and that not all peoples were equally ready for that stage, allowed them to justify aspects of Italy's African empire. By examining their differing treatment of the people of Egypt, Tunisia, and East Africa, moreover, the article shows the extent and complexity of their classification of civilizations. While they showed a high level of sympathy for the more ‘Europeanized’ Egyptians, they viewed the people of Eritrea as ‘savages’ in need of Italian guidance and intervention. Finally, the article shows how they attempted to distinguish their version of benign and respectful colonization from the more avaricious or aggressive practices of the French or British empires.
Large-scale functional network connectivity mediates the associations between lipids metabolism and cognition in type 2 diabetes
Authors: Zhang Wen , Fu Linqing , Bi Yan , Liu Jiani , Li Xin , Zhang Xin , Zhang Zhou , Miao Yingwen , Cheng Haiyan , Zhang Bing
Published: October 2023

Type 2 diabetes (T2D) is associated with dyslipidemia and mild cognitive impairment. This study investigated the relationships between serum lipids metabolism, cognition, and functional connectivity (FC) within and between brain networks in T2D patients. The study included 102 T2D patients and 45 healthy controls who underwent functional magnetic resonance imaging, lipid profile tests, and cognitive assessments. Thirteen functional networks were identified using independent component analysis. The statistical analyses included multivariate analysis of covariance, partial correlation, canonical correlation, and mediation analyses. We found widely reduced between-network FCs in T2D, especially between the ventral sensorimotor network (SMN) and dorsal attention network (DAN) (p = 0.001) and between the ventral SMN and lateral visual network (VN) (p < 0.001). Moreover, lower between-network FCs were correlated with worse serum lipids metabolism and poorer cognitive performance (all p < 0.05). Importantly, between-network FCs mediated the relationship between lipid metabolism and cognition (β = −0.3136, 95% CI: −0.7660, −0.0186). Within-network analyses revealed altered FCs within the anterior default mode network, DAN, and lateral VN, each positively correlated with global cognition (all p < 0.01). Our results suggest the potential of improving cognitive function by regulating serum lipids in individuals with T2D.
[18F]LW223 has low non-displaceable binding in murine brain, enabling high sensitivity TSPO PET imaging
Authors: Knyzeliene Agne , MacAskill Mark G , Alcaide-Corral Carlos J , Morgan Timaeus EF , Henry Martyn C , Lucatelli Christophe , Pimlott Sally L , Sutherland Andrew , Tavares Adriana AS
Published: October 2023

Neuroinflammation is associated with a number of brain diseases, making it a common feature of cerebral pathology. Among the best-known biomarkers for neuroinflammation in Positron Emission Tomography (PET) research is the 18 kDa translocator protein (TSPO). This study aims to investigate the binding kinetics of a novel TSPO PET radiotracer, [18F]LW223, in mice and specifically assess its volume of non-displaceable binding ( VND) in brain as well as investigate the use of simplified analysis approaches for quantification of [18F]LW223 PET data. Adult male mice were injected with [18F]LW223 and varying concentrations of LW223 (0.003–0.55 mg/kg) to estimate VND of [18F]LW223. Dynamic PET imaging with arterial input function studies and radiometabolite studies were conducted. Simplified quantification methods, standard uptake values ( SUV) and apparent volume of distribution ( VTapp), were investigated. [18F]LW223 had low VND in the brain (<10% of total binding) and low radiometabolism (∼15–20%). The 2-tissue compartment model provided the best fit for [18F]LW223 PET data, although its correlation with SUV90–120min or VTapp allowed for [18F]LW223 brain PET data quantification in healthy animals while using simpler experimental and analytical approaches. [18F]LW223 has the required properties to become a successful TSPO PET radiotracer.