bluuebunny/crossref_metadata_2025 huggingface dataset:
The Use of Cartoon Media for Junior High Students of Their Writing Ability
Authors: Siswandi S.
Published: March 2022

This research was proposed from the problem of students writing ability in the descriptive text of the eight-grade students at MTs N 1 Pekanbaru. They were not able to write in English well. The objective of this research was to find out whether there was or nor the significant effect of using cartoon media. The design of this research was Quasi-Experimental Research. The Population of this research was all of the eighth-grade students. The total number of the population was 350 students. The writer used a cluster sampling technique by taking only two classes as a sample; VIII.1 that co­nsisted of 35 students as experimental class and VIII.2 consisted of 35 students as control class. So the number of samples from two classes was 70 students. To analyze the data, the writer used an independent sample t-test. Based on the analysis of the t-test Formula, the sig. value is 0.000. It could be stated that 0.000<0.05. Then, the effect size is 0.387 categorized into a moderate level. The writer concluded that there is a significant effect of using cartoon media on students’ writing ability in the descriptive text at MTs N 1 Pekanbaru. And the biggest effect occurred on the writing ability where the effect size is 0.14 categorized into large effect.
Improving Reading Comprehension By Using Internet Of The Fourth Semester Students Of Stiba Persada Bunda
Authors: Masbiran Gunaldi
Published: March 2022

The goal of this research was to get information whether the students’ reading comprehension could be improved through Internet using at the Fourth Semester Students of School of  Foreign Language at Persada Bunda. The cases were some students’ reading comprehension still low or below standard passing of test. The research was classroom action research. The participants of this research were the Fourth Semester Students of School of  Foreign Language at Persada Bunda. They are consisted of 12 students. This research was held into two cycles, each cycle consisted of three meetings. The research data were divided into two major types namely, quantitative and qualitative data. The quantitative data were taken through reading comprehension test. The qualitative data were collected through observation, and field notes. The result of the analysis showed that the students grades improved after internet using. The improvement happened on each cycle at the research. The improvement of students’ reading comprehension scores were influenced by factors such as motivation, interest, and classroom atmosphere. Thus, it was concluded that internet using can improve students’ reading comprehension. The internet using  also increases students’ speed in reading comprehension that can be used by students of School of Foreign Language at Persada Bunda. Therefore, the internet using is recommended to be used by the students and lecturer in teaching and learning reading comprehension at the School of Foreign Language of Persada Bunda.
The Correlation between Students’ Willingness to Communicate and Their Speaking Performance at the Tenth Grade of MAN 1 Pekanbaru
Authors: Al -hafiz Muhammad Ichsan , Gushendra Rizky
Published: March 2022

The purpose of this research is to examine whether there is any significant correlation between willingness to communicate and speaking performance at the tenth-grade students of MAN 1 Pekanbaru. There were 244 students as samples by using the simple random sampling technique. This research approach was a quantitative method and the technique used in this research was a correlational technique. In collecting the data, the writer distributed the questionnaire to the respondents to determine the willingness to communicate, which consist of 55 item statements and used documentation of the students' speaking score made by English teachers at the school to determine the speaking performance. The writer used Spearman correlation through SPSS 26.0 to analyze the data. The result of this research showed that sig.r obtained value is 0.000 lower than alpha value (0.05). it means that null hypothesis (Ho) is rejected while alternative hypothesis (Ha) is accepted. In conclusion, there is a correlation between willingness to communicate and speaking performance at the tenth-grade students of MAN 1 Pekanbaru.
Students’ Difficulties in Answering the Written Expression Section of the TOEFL Test at English Study Program of State Islamic University of SUSKA Riau
Authors: Fitri Mainar
Published: March 2022

TOEFL test is one of the requirements for the students of English Study Program of State Islamic University of Sultan Syarif Kasim Riau (UIN Suska Riau) to finish their study at S1 Degree.  Based on the researcher’s observation, most of the students did not pass the TOEFL Test.  The students followed the test for several times till they reached the passing grade. It seemed that the students got difficulties in answering the TOEFL Test. So, in this research the researcher focused on analyzing the students’ difficulties in answering the Written Expression section of the TOEFL test.  The aims of this research were to identify the categories of items in the Written Expression section of the TOEFL test which were difficult for the fourth semester students of English Study Program UIN Suska Riau, and to identify which categories of items that were easy for the students. This research was a quantitative research. The researcher analyzed the categories of items tested in TOEFL test, especially in the Written Expression section. There were 12 categories of items tested in the Written Expression section of the TOEFL test based on Longman Preparation Course for the TOEFL Test by Deborah Phillips (2000: 144-221). The categories consisted of subject-verb agreement, parallel structure, comparative and superlative, the use of the verbs, the forms of the verbs, passive verbs, nouns, pronouns, adjectives and adverbs, articles, prepositions and usages   The result of the research showed that all of the categories of items were difficult for the students. None of the categories of items were easy for the students. The most difficult category for the students was usages. So, in general, the students extremely got difficulties in answering the Written Expression section of the TOEFL test.
HUBUNGAN ANTARA BIMBINGAN ORANG TUA DENGAN MINAT BELAJAR REMAJA DI KAMPUNG MELAYU KEC. LUBUK BASUNG KAB. AGAM
Authors: Fitri Lidia , Sunarti Vevi
Published: March 2022

This research is motivated by the low of parental guidance on adolescent learning interest in the Melayu Village, Lubuk Basung District, Agam Regency. aims to see a picture of adolescent learning interest, a picture of parental guidance and see the relationship between parental guidance and adolescent learning interest.This type of research is using a quantitative with a correlational approach. The population in this study were all teenagers in the Malay Village, Lubuk Basung District as many as 21 people. Sample was taken as much as 50% of the population of 11 people. The results of this study indicate that parenting still low, adolescent learning interest is still lacking; and there is a significant relationship between parental guidance and adolescent learning interest in the Melayu Village, Lubuk Basung District, Agam Regency. It is recommended for parents to be able to provide encouragement and motivation for children to further improve and be more active in learning activities, as well as be a guide for further researchers.

keywords: parental guidance and interest in learning
Hubungan Metode Pembelajaran Alquran dengan Minat Belajar Peserta Didik pada Progam Tahsin Tilawah di Masjid Raya Korong Pasir Baru Kecamatan Sungai Limau Kabupaten Padang Pariaman
Authors: Ulfi Ulfi , Jalius Jalius
Published: March 2022

This study was motivated by students’ low interest  in learning the tahsin reading program at the Korong Pasir Baru Mosque, Sungai Limau District, Padang Pariaman Regency. This is prabably related it has something to do with the use of learning methods used by teachers.This type of research is quantitative using a correlational approach. The population of this research were all students of recitation  recitations at the Great Mosque of Korong Pasir Baru was totalled 30 people and taking a sample of 24 people. Data collection methode using a questionnaire. We used the percentage  and the correlation Spearman formula as the data analysis. The results showed that the Qur'anic learning method was categorized as low, students' interest in learning was still low, and there was a considerable relationship either the Koranic learning method and students' learning interest in the recitation program at the Korong Pasir Baru Grand Mosque, Sungai Limau District, Padang Pariaman Regency. It is hoped that teachers will pay more attention to the use of learning methods because this affects students' interest in learning. the better the learning method used, the higher the learning interest of students. And vice versa learning methods that are not good will affect the learning interest in student.
Negociando con el new momism: un análisis comparado de la maternidad en Big Little Lies y Little Fires Everywhere desde la figura de Reese Witherspoon
Authors: Puig-Fontrodona Laia
Published: March 2022

El objetivo principal de este artículo es analizar la pervivencia y evolución de la ideología del new momism en Big Little Lies y Little Fires Everywhere, para ver sus contradicciones a través de la figura de Reese Witherspoon, actriz y productora.  Seguimos la metodología de los star studies, que parte de analizar la star persona de la actriz para ver como dialoga con ambas series, a través de un análisis textual comparativo combinado con el análisis del arquetipo de maternidad propuesto por el new momism. Este arquetipo de maternidad sigue vigente, a través de elementos como el dictado de la “libre elección” y de las mommy wars. Aun así, veremos como las madres de estas ficciones interpretan una mascarada: al mezclar posfeminismo y feminismo, hay brechas en el discurso del new momism que revelan la insatisfacción que este conlleva y la imposibilidad de cumplir sus cánones de perfección.
Methodological Naturalism and Scientific Success
Authors: Prasetya Yunus Adi
Published: March 2022

Several metaphysical naturalists argue that the success of science, together with the claim that scientists adhere to methodological naturalism, amounts to strong evidence for metaphysical naturalism. I call this the scientific-success argument. It is argued that the scientific-success argument is similar to the no-miracles argument for realism in philosophy of science. On the no-miracles argument, the success of science is taken as strong evidence that scientific theories are (approximately) true. Based on this similarity, some considerations relevant to one argument may also be relevant to the other. One particular consideration is explored. The selectionist response to the no-miracles argument states that on an evolutionary model of science, in which scientific theories are accepted only after surviving a rigorous selection process, the no-miracles argument fails. The selectionist response also applies to the scientific-success argument. If scientific theories are selected for success, we do not need to explain the success of science by appealing to metaphysical naturalism.
First Record of Podichnus in Byronid Shell from the Lower Devonian (Pragian) of the Prague Basin, Czechia
Authors: Mergl Michal
Published: March 2022

Brachiopod etching trace Podichnus, typically with centrifugally arranged clusters of holes or slits, has hitherto been known only in calcium carbonate substrates. The similar etching trace is newly described on calcium phosphate substrate. The trace Podichnus isp. in a wall of a phosphatic byronid test was observed in the lower Devonian Vinařice Limestone (Pragian) in the Koněprusy area of the Prague Basin in the Barrandian area, the Czech Republic. The trace is smaller that majority of described species of this fixichnia, and displays a smooth central disc surrounded by two circlets of holes or pits. Some holes penetrate through wall of byronid test without any biotic response of a byronid. The maker of Podichnus isp. is uknown but among the associated fossils are eligible candidates including rhynchonellids, orthids and terebratulids. It is rare direct evidence of etching activity of the pedicle in the Lower Palaeozoic and the first finding of Podichnus in the Devonian in the Prague Basin. The emended diagnosis of the ichnogenus is presented herein.
Dampak Sikap terhadap Tuhan pada Kepuasan Hidup Mahasiswa Kristen di Jabodetabek pada Masa Pandemi
Authors: Aditya Yonathan
Published: March 2022

Mempunyai persepsi positif terhadap Tuhan di masa sulit penting untuk menjaga kesehatan mental. Sayangnya cukup banyak yang menjadi kecewa terhadap Tuhan di masa pandemi. Penelitian ini bermaksud meneliti persepsi positif dan negatif terhadap Tuhan dari mahasiswa Kristen di Jabodetabek pada saat pandemi. Hasil regresi berganda data dari 369 responden (99 pria dan 270 wanita) menemukan bahwa persepsi negatif memprediksi penurunan kepuasan hidup sedangkan persepsi positif memprediksi kepuasan hidup yang lebih tinggi. Selain itu, persepsi positif dapat mengurangi dampak negatif dari persepsi negatif terhadap kepuasan hidup. Hasil dari penelitian ini menyiratkan selama persepsi positif tetap tinggi, efek negatif dari persepsi negatif dapat dikendalikan.
Gambaran Tingkat Kepuasan Mutu Pelayanan Poliklinik Gigi Rumah Sakit TK. IV Samarinda Selama Masa Pandemi COVID-19
Authors: Sadaningsih Dea Pratiwi , Listiyawati Listiyawati , Irsal Imran
Published: March 2022

Dental care has been significantly impacted by the COVID-19 pandemic. Aerosol dispersal in most dental procedures can present a high risk of infection to both dentists and patients. Dental Polyclinic of Tk.IV Hospital is one of the hospitals in Samarinda that is still operating during the pandemic COVID-19, implementing health protocols such as limiting dental procedures and reducing dental visits. These restrictions will probably affect patients’ perceptions of service quality they receive and show health quality service provided by the hospital. This study aims to describe the level of satisfaction towards service quality at the Dental Polyclinic of Tk.IV Hospital Samarinda during the COVID-19 pandemic. This descriptive observational study was based on interview and questionnaire administration for 104 patients with inclusion and exclusion criteria. Two variables observed in this study were service quality with SERVQUAL dimension and patients’ level of satisfaction. The findings revealed that the average patients’ level of satisfaction was 92.62%. The dimensions of tangible 91.4%, reliability 92.8%, responsiveness 92.55%, assurance 93.93%, and empathy 92.45% were satisfactory, ranging from 81% and 100%. In general, according to those five dimensions, patients reported that the service quality was excellent and very satisfactory
Uji Efek Tonikum Ekstrak Etanol Daun Pecut Kuda (Stachytarpheta jamaicensis L. Vahl) pada Mencit Putih Jantan (Mus musculus)
Authors: Yuliawati Yuliawati , Rofifah Dhia Savira  , Diah Tri Utami
Published: March 2022

Tonic is a substance that can increase the bodys defense system. The stimulant effect that is intertwined with the tonic effect is carried out by the central nervous system. Pecut kuda leaf and bases are useful as stimulants and tonics. This research aims to determine  the tonicum effect of ethanolic extract  pecut kuda leaf in mice. This was an experimental study with completely randomized group design, using  male white mice and divided into five  namely two control groups (K- given Na CMC 0,5% and K+ given 13 mg caffeine) and three treatment groups (ethanolic axtract of pecut kuda with a dose 50, 100 and 200 mg/kgBW) and each treatment group was repeated 5 times. The methods used were natatory exhaustion test, hanging test and sleep induction test for the parameters observed were the mice'defense on the surface of the water, the duration of the mice endurance on the hanging device and the time the mice fell asleep.The results of the observation data using Duncan's One Way ANNOVA test. The results showed that the pecut kuda leaf extract was effective against the tonic effect test at doses of 50, 100, 200 mg/kgBW. It can be said that pecut kuda leaf extract at a dose of 200 mg/kgBW has almost the same effect as K+ (13mg caffeine).
Peran Disregulasi Imunitas dalam Terapi Kusta pada Area Endemis: Artikel Review
Authors: Prakoeswa Flora Ramona Sigit , Maharani Faradiba
Published: March 2022

Leprosy, a chronic infectious disease caused by Mycobacterium leprae, causes health problems and endemic in several countries. The number of new cases of leprosy is constantly reported in endemic countries. Therapeutic efforts in leprosy patients are carried out with the aim of reducing the level of transmission and disability of leprosy patients. Leprosy therapy with the use of a multidrug regimen (MDT) has been shown to be able to reduce the number of leprosy cases but has not been able to suppress the rate of growth of new leprosy cases. The constant number of new cases of leprosy in endemic areas indicates community infection and the inability of MDT as a single strategy to complete treatment and stop the transmission of leprosy. The transmission of leprosy is known to be multifactorial involving: microbial factors, host factors, and environmental factors. These factors are thought to cause immune dysregulation and increase the risk of leprosy infection in people living in endemic areas. An understanding of immune dysregulation is needed to achieve succesful treatment and the eradication of leprosy.
DA MILENAR SABEDORIA DAS PESSOAS IDOSAS AOS LIVROS SAPIENCIAIS
Authors: Correia Júnior João Luiz , Torres Maria de Fátima Nóbrega
Published: March 2022

A sabedoria das pessoas que foram agraciadas com a longevidade foi bastante valorizada nas culturas pré-modernas. A literatura sapiencial da tradição bíblica, que advém do Oriente Médio, no Crescente Fértil, há mais de três mil anos, preserva em seus escritos sagrados essa deferência especial às pessoas idosas, concebidas como memórias vivas da história, contada à luz da fé em Deus, para que nada caísse no esquecimento. O presente artigo tem como objetivo comentar alguns textos seletos dos livros sapienciais da Bíblia (Provérbios, Jó, Eclesiastes, Eclesiástico e Sabedoria) que valorizam a contribuição da milenar sabedoria das pessoas idosas, em temas relevantes à cultura sapiencial. A metodologia utilizada é da pesquisa bibliográfica, na área dos estudos bíblicos e teológicos, por meio de bibliografia específica. Os resultados alcançados apontam para o fato de que as pessoas mais velhas, letradas ou iletradas, desde o ciclo familiar nas pequenas aldeias (pais, mães e avós), até os velhos sábios das escolas rabínicas, todos deram importante contributo não só para a cultura sapiencial do Judaísmo, mas para todas as culturas que valorizam o conhecimento.
DIANTE DA POLÍTICA OPRESSORA, OS CORPOS DOS ENAMORADOS ACENAM REBELIÕES (CT 6,4 – 7,10)
Authors: Frizzo Antonio Carlos
Published: March 2022

Na hermenêutica bíblica, compreendida por “leitura descolonizadora”, verificamos que o projeto de volta a Sião, na época pós-exílica (538 a.C), durante o império persa, tão bem justificada nos livros de Neemias e Esdras, legitima, sim, um projeto contra pequenas experiências tribais, afronta culturas e corpos para legitimar um império que durou por mais de dois séculos. Eis o objetivo do artigo que tem na narrativa do livro dos Cânticos dos Cânticos (6,4-84), sua análise bíblica para desconstruir ideologias e práticas dominadoras.
A rare association of esophageal atresia and tracheoesophageal fistula with microgastria: A case report
Authors: Zulpi Prashant K. , Halgeri Anil B. , Kalavant B Akshay , Kulkarni Vijay K.
Published: March 2022

We present a case of esophageal atresia with tracheoesophageal fistula which was associated with microgastria. Following primary esophageal anastamosis developed leak and went into severe sepsis and died.
Kikuchi – Fujimoto disease presenting as FUO in an adolescent girl
Authors: Sahana B. K. , Ratageri Vinod H. , Reddy Purushotham
Published: March 2022

Kikuchi – Fujimoto disease is a rare usually self-limiting disease mainly reported in Asian population. Herein we are reporting same disease in a 16-year-old child who presented with FUO.
Unusual manifestation of the central hypothyroidism
Authors: Tara H , Ratageri Vinod H. , Patil Vishal B.
Published: March 2022

The central hypothyroidism occurs in one in 16,000–30,000 infants. The common presentations include lethargy, sluggishness, hoarse cry, and feeding. Seizure and apnea are a rare manifestations. Herein, we describe the case of an infant with the central hypothyroidism who presented with seizures.
Determination of Learning Styles of Hematologists in Turkey and Evaluation of the Effect on Educational Success
Authors: TAYFUN KÜPESİZ Funda , GÜRPINAR Erol
Published: March 2022

Aim: Learning style can be defined as individual differences in the processes of perceiving information, processing, and placing information in the mind. Creating educational models and learning environmentssuitable for individuals' learning style characteristics will ensure that desired learning outcomes are achieved. Kolb Learning Styles Scale is frequently used to determine learning styles. In our country andin the literature, there is no study evaluating the learning styles of physicians related to minör specializations. With this research, it was aimed to determine the learning styles of hematology specialists.Methods: Kolb learning styles scale and questionnaire were applied to hematology specialists who participated in the "Masterclass" program organized by the Turkish Society of Hematology between 2016-2019, using the online survey monkey method.Results: 70 hematologists from five different masterclass programs participated in the study. Of the hematologists, 61.4% (n= 43) were female and 38.6% (n= 27) were male. The mean age of the participants was calculated as 40 ± 3.16 years [median=39.96 years (35-54)], and the mean duration of specialistic was 4.81 ± 11.39 years [median= 5 (1-10 years)]. The learning style of hematologists is converging with 38 people (54.3%), assimilating with 16 people (22.9%), accommodating with 10 (14.3%), and diverging with 6 people (8.6%) was defined. There was no significant difference in terms of gender, major specialization, titles, institutions, and learning styles of the participants (p> .05). The mean final exam scores of the hematologists were calculated as 63.96 ± 10.99 points [median= 62 (40-91 points)]. It was observed that gender, age, duration of specialization, major specialization, academic title, and learning style had no effect on the final exam score (p>.05).Conclusions: Hematology specialists were found to have predominantly converging and assimilating learning styles. Considering the characteristics of these learning styles while creating hematology education programs and learning environments can contribute positively to traning program.
Assessment of heavy rainfall forecasts over the southern Vietnam by using WRF-ARW with different physical parameterization schemes
Authors: Thang Vu Van , Lars Robert Hole , Tien Du Duc , Kien Truong Ba , Thuc Tran Duy
Published: March 2022

This research aims to investigate heavy rainfall forecasting over southern Vietnam (SVN) by using the Weather Research and Forecasting with the Advanced Research dynamical solver (WRF-ARW) model. The selection of 34 heavy rainfall events from 2012 to 2016 over SVN during the active phase of the Southeastern Asian summer monsoon was studied. Sixty different WRF-ARW configurations are determined from three cumulus schemes (Kain–Fritsch with three different types of trigger mechanisms, Grell–Devenyi and Betts– Miller–Janjic), three planetary boundary schemes (Yonsei University, Mellor–Yamada–Janjic and Bougeault-Lacarrère) and four cloud microphysics schemes (Lin, Thompson and two WRF microphysics schemes with five and six moments). Typical skill scores are calculated based on the surface observation data and spatial verifications are carried out using the fraction skill score (FSS) and grid rainfall observations from the satellite-based GSMaP product. It is clear that the most sensitive to heavy rainfall forecasts were cumulus scheme selections, especially at thresholds below 50 mm/24 h. The configurations using the Kain–Fritsch scheme have wet bias issues. However, overall, in terms of a high probability of detection (POD) and high threat scores (CSI), the most skillful configuration was the use of the Kain–Fritsch scheme with the third trigger mechanism in combination with local diffusion planetary boundary schemes.
Analyzing the Forest Fire Risk of a Tropical Deciduous Forest in Southern Western Ghats Region in Wayanad Wildlife Sanctuary, Kerala, India
Authors: Vineetha P. , Sarun S. , Jayalekshmi V.K. , Reghunath Rajesh
Published: March 2022

In recent years, the forest fire has increased at an alarming rate in India. It has become a common incident in many areas of Wayanad Wildlife Sanctuary situated along the North-Eastern part of Kerala, lying in the Western Ghats. The forest fire incidents happen mainly in the pre-monsoon period ranging from February to April. Using various forest risk parameters, the study analyses the forest fire risk zone in the Wayanad Wildlife Sanctuary. A weighted index method using GIS and Remote sensing was acquired to obtain and distinguish the forest fire-risk map by including the risk variables such as vegetation, topographic factors, land surface temperature and proximity to the road and settlements. The forest fire risk zone map integrates the observed variable with the help of the GIS platform. Out of the study area's total of 412 sq km, 24.65 % falls in very high and 33.39 % comprises the high fire risk zones. Validation of the forest fire risk zone map with the fire locations illustrates that most fire locations (72 %) fall under high and high-risk zones. The result of the study could help the decision-makers to implement fire management plans and strategies.
A review on beauvericin production from Fusarium, its biosynthesis, mode of action and bioactivities
Authors: Rana Shiwali , Singh Sanjay Kumar
Published: March 2022

This review provides comprehensive information on beauvercin, a cyclic hexadepsipeptide, produced by selected fungi like Beauveria, Paecilomyces, Polyporus, Isaria and Fusarium. The biosynthetic pathway of beauvericin production is elaborated. Numerous bioactivities like anticancer, antiviral, cytotoxic, antiplatelet aggregation, antimicrobial, antiprotozoal, insecticidal properties are reviewed. The potential of beauvericin to diminish the growth of gram-positive or gram-negative pathogenic bacteria and inhibition of melanin production are well documented. It has been noted that beauvericin possesses ionophoric property which renders it these bioactivities. Being genotoxic, beauvericin has been proved to cause apoptosis by DNA fragmentation, chromosomal aberrations and micronucleus formation. In this review, the production yield reported from the different strains of Fusarium spp. is also compiled. This documentation will be of great help to the researchers working on optimization and productivity enhancement studies of beauvericin. Beauvericin needs to be studied in detail as there are many gaps which need to be fulfilled.
The Role of TLRs in the Immunomodulation of Tumor Microenvironment
Authors: Singh Reetika , Das Asmita
Published: March 2022

The review focuses on the modulation of the Tumor Microenvironment through toll-like receptors expressed on the tumor cells and the immune cells found in the vicinity of the tumor mass. The expression of these TLRs is effectively up-regulated and downregulated to abrogate the tumor growth. The function of immune cells like Treg cells, CAFs etc. is also altered in the tumor microenvironment leading to either promotion or regression of the tumor mass. Various molecules including some plant-derived polysaccharides have recently come up as potential therapeutic molecules that enhance the TLR tumorkilling activity. A few TLR agonists are known to increase the chemotherapeutic drug’s efficacy, for instance, co-administration of Resiquimod with Oxaliplatin. Even after the continuous advancements in the knowledge of tumor microenvironment and its regulation, this sphere holds immense potential for further research. According to the studies, the prospect of immunomodulation of tumor microenvironment using TLR regulation lies in finding more plant-based agonists for various TLR molecules.
Bioremediation of melanised poultry feather waste for production of mosquitocidal keratinase
Authors: Mandal Arpita , Paul Tanmay , Mondal Keshab Chandra
Published: March 2022

Melanised chicken feather wastes are great resources of amino acids and oligopeptides which can be biodegradable by the bacterial keratinase enzyme. Biodegradation of melanised chicken feathers waste directed by P. woosongensis TKB2 cells was successfully carried out in 8 L EYELA-MBF-800ME laboratory scale fermentor. The fermentation processes were conducted at 30 °C, 700 rpm agitation speed and 0.7 vvm air flow rate in a basal medium (%, w/v, 0.05% K2HPO4; 0.025% MgSO4; 0.02% CaCO3 and 5% NaCl) containing 1.0 % (w/v) melanised feathers. Highest net levels of released feathers hydrolysis end products like soluble proteins of 4.15 mg/mL and an adequate level of free amino acids (isoleucine>serine>alanine>arginine>histidine>vali ne>phenylealanine>leucine>tyrosine), keratinolytic protease activity (71.68 UmL-1) and 98.8 % feather degradation capability in the fermentor were greatly comparable to those of shake flasks. The crude enzyme showed optimum activity against Anopheles stephensi larvae in native water at pH 8.0 and 50 °C (LD50-0.60 UmL-1 at 48 h). Therefore, the studied keratinase can be used as an effective mosquitocidal agent.
Standardization of protocol for shoot regeneration in Bacopa monnieri (L.) Pennell using leaf explants
Authors: Chauhan Ruchi , Shirkot Poonam
Published: March 2022

Bacopa monnieri (L.) Pennell commonly called ‘Brahmi’ is used as a medicinal herb since ages. It is known for its revitalizing and nootropic actions in Ayurvedic medicine as it strengthens memory as well as intellect. This activity of the plant has been accredited to a mixture of triterpenoid saponins, sterols and alkaloids. Of these saponins, Bacoside-A and Bacoside-B have been found to be the most important. Present work aimed to establish direct and indirect shoot regeneration protocol in Bacopa monnieri (L.) Pennell using leaf explants. It was found that MS medium supplemented with 1.0 mg/l 2, 4-D and 0.5 mg/l BAP was best for callus formation (53.33%). Leaf explants showed both direct and indirect regeneration and MS medium supplemented with 6.0 μ mol/ was found to be best for shoot regeneration.
Synthesis of Levofloxacin based Chiral Reagent and its Application in Determination of Optical Purity of Essential Racemic Amino Acids using RP-HPLC
Authors: Bireddy S.R. , Bantu T.R. , Alwera V. , Vashistha V.K. , Alwera S. , Sehlangia S.
Published: March 2022

In this report, the activated chiral reagents of the (S)- levofloxacin (CR-Lfx) were prepared via coupling reaction of N-hydroxysuccinimide and characterised by UV, IR, HRMS, NMR and CHNS. Three essential racemic amino acids were chosen for the chiral recognition study. The diastereomeric derivatives of the chosen amino acids were prepared under microwave heating conditions, using highly reactive activated reagents (CR-Lfx). RP-HPLC was used to separate the prepared diastereomeric derivatives. The effect of varying mobile phase concentrations and sample concentrations was optimised. The density functional theory calculations were performed using Gaussian 09 rev A.02 and hybrid density functional B3LYP with 6-31G* basis set software to create the lowest energy optimised structures of diastereomeric derivatives. LOD (0.208 ng mL−1), LOQ (0.624 ng mL−1), calibration range (0.02-2.0 mg mL−1), correlation coefficient (0.998) and recovery were the validation parameters for our method (99.54 and 99.89 percent for intra-day assay and 99.87 and 99.32 percent for inter-day assay).
Synthesis, molecular docking, antibacterial and antifungal studies of Fe (II) and Ni (II) complexes of N1, N2-bis((1,3-diphenyl-1H-pyrazol-4-yl) methylene) ethane-1,2-diamine
Authors: Sandhya P.V. , Rejimon P.K. , Satheesh Kumar K.V.
Published: March 2022

1,3-Diphenyl pyrazole terminated ligand N1,N2- bis((1,3-diphenyl-1H-pyrazol-4-yl)methylene)ethane- 1,2-diamine and its iron and nickel complexes were synthesized. The structural environment of synthesis of ligand and its metal complexes was confirmed by elemental analysis, UV-Vis, FT-IR 1HNMR and 13NMR spectroscopic techniques. These compounds were further screened in vitro antimicrobial activities against some bacterial and some fungal strains and compared with the standard drugs. The result showed that the metal complexes are good candidates as antimicrobial agents than the ligands at the same concentration. The biological activity of the synthesized analogues was predicted in molecular docking experiments with specific target proteins. The molecular docking studies were carried out using the online software Arguslab 4.0.1 and revealed that both the ligand and its complexes are exhibiting a possible interaction with the proteins murD ligase and c-met Kinase.
Preparation of high efficient carbon dots from renewable and sustainable biomass resources
Authors: Chutia Gobinda Prasad
Published: March 2022

Carbon dot (CD) is a novel type of zero-dimensional nanomaterials and has drawn much attention due to its excellent properties including good water solubility, low toxicity, high photostability, biocompatibility, outstanding selectivity and sensitivity for target analytes. The utilization of green biomass resources as a carbon source offers an economically feasible synthetic route for the large-scale production of CDs. Biomass waste is a cheap, highly abundant renewable resource that can promote the synthesis of high efficient CDs for sustainable application in numerous fields including drug delivery, bioimaging and sensing. This study reviews the feasibility of different biomass materials as a potential precursor for the preparation of CDs through different synthetic approaches such as hydrothermal, pyrolysis, chemical oxidation, microwave-induced treatment etc. and their practical applications in various fields.
Comparative study of ozone-based AOPs for degradation of Reactive Red 120
Authors: Sharma Sandip , Ruparelia Jayesh
Published: March 2022

The present work focuses on the comparative study of ozone-based advanced oxidation processes (AOPs): O3, O3/UV and O3/UV/PS to degrade synthetic wastewater containing Reactive Red 120 (RR120) dye. The effect of various parameters: pH, ozone flow rate, initial concentration of dye, persulfate dosage and UV light intensity was analyzed to assess the performance efficiency of AOPs. All three AOPs' performance was evaluated on decolorization, %TOC removal and ozone consumption. The highest degradation rate of 86.83% was achieved for O3/UV/PS, followed by 71.53% and 66.82% for O3/UV and O3 respectively. This better efficiency of O3/UV/PS is attributed to the fact that persulfate ions (S2O8 2-) upon activation produce sulfate radical (SO4 - ●), which is a powerful oxidant capable of degrading a wide variety of recalcitrant organic compounds. The study reveals that the efficiency of degradation of RR120 follows the order: O3/UV/PS > O3/UV > O3.
The electrochemical measurement of salt diffusion coefficient, apparent cation transference number and ionic conductivity for a thin-film electrolyte.
Authors: Pożyczka Karol
Published: March 2022

A manuscript submitted to Electrochimica Acta._________ Further development of the electrochemical measurement procedure, namely the Symmetric Polarization Procedure (SPP), is described. The SPP allows for additional verification of measurement assumptions through a quick and simple inspection of a symmetry between the procedure outcomes. It also improves the precision of estimated transport properties. A considerable emphasis was also put on detailed outcomes analysis. In particular, a newly developed approach to the analysis of restricted diffusion data is proposed. This approach is based on a power law which is a common form for the rate equation, therefore it allows for a precise estimation of the salt diffusion coefficient and, innovatively, the diffusion domain. Importantly, as a result of this approach, the subdiffusive motion of species is recognized in every electrolyte examined herein. Additionally, four approaches that lead to a quantification of the apparent cation transference number are also extensively discussed. It has been demonstrated, how a knowledge about the salt diffusion coefficient, the apparent cation transference number and the ionic conductivity can be used to evaluate the electrochemical performance of an electrolyte. It is also shown, how these properties can be utilized to approximate the limiting-current density and the deviation from Nernst-Einstein equation.
Computational Prediction of Speciation Diagrams and Nucleation Mechanisms: Molecular Vanadium, Niobium and Tantalum Oxide Nanoclusters in Solution
Authors: Petrus Enric , Segado-Centellas Mireia , Bo Carles
Published: March 2022

Understanding the aqueous speciation of molecular metal-oxo clusters plays a key role in different fields such as catalysis, electrochemistry, nuclear waste recycling, and biochemistry. To accurately describe the speciation, it is essential to elucidate the underlying self-assembly processes. Herein, we apply a computational method to predict the speciation and formation mechanisms of polyoxovanadates, -niobates and -tantalates. While polyoxovanadates have been widely studied, polyoxoniobates and -tantalates lack the same level of understanding. In the first place, we proposed a pentavanadate cluster ([V5O14]3-) as a key intermediate for the formation of the decavanadate. Our computed phase speciation diagram is in particularly good agreement with the experiments. Secondly, we report the formation constants of the heptaniobate, [Nb7O22]9-, decaniobate, [Nb10O28]6-, and tetracosaniobate [H9Nb24O72]9-. Additionally, we have computed the speciation and phase diagram of niobium, which so far was restricted to Lindqvist derivates. Finally, we have predicted the formation constant of the decatantalate ([Ta10O26]6-) in water, even though it had only been synthetized in toluene. Furthermore, the corresponding speciation and phase diagrams for polyoxotantalates have been also calculated. Overall, we show that our method can be successfully applied to different families of molecular metal oxides without any need for readjustments; therefore, it can be regarded as a trustworthy tool for exploring polyoxometalates’ chemistry.
Germylene stabilized copper(I) halide complexes as catalysts for click and C-S coupling reactions
Authors: Yadav Dhirendra , Mahawar Pritam , Kumar Hemant , Sarkar Debotra , Sinhababu Soumen , Sharma Mahendra Kumar , Jha Chandan Kumar , Karwasara Surendar , Selvarajan Nagendran
Published: March 2022

Aminotroponiminato(chloro)germylene stabilized mononuclear copper(I) iodide complex [{(i-Bu)2ATIGeCl}(CuI)(C5H5N)2] (1) was used as catalyst for regioselective cycloaddition reactions and found that it works efficiently. To realize how the halogen atom (X), the nuclearity of the CuX core, and the number of germylene donors in the copper complexes can affect their catalytic potential, a series of copper complexes [{(t-Bu)2ATIGePh}2(CuX)] (X = Cl 3, Br 4, I 5) with monomeric CuX core and [{(t-Bu)2ATIGePh}3(CuCl)3] (6) containing trimeric Cu3Cl3 core were prepared and used as catalysts. The results indicated that complex 1 is a better catalyst than complexes 3-6. Given this, the catalytic utility of complex 1 in the C-S coupling reactions was tested to find that it functions effectively for a wide variety of substrates. Complexes 3-6 were characterized in the solid-state through single-crystal X-ray diffraction studies.
Case Study on Severe Adverse Drug Reactions Caused by Rituximab
Authors: Ch. Sri Lakshmi Mallika
Published: March 2022

Rituximab is a chimeric IgG1 immunoglobulin that attacks B cells' CD20 molecules. Its efficiency in the treatment of B cell malignant proliferative illness has been proven since 1997. Rituximab is also used to treat autoimmune illnesses involving B cells, such as autoimmune hemolytic anaemia, autoimmune thrombocytopenia, rheumatoid arthritis (RA), Sjogren's syndrome (SS), and systemic lupus erythematosus (SLE) (SLE). A 19-year-old female patient was admitted to the hospital with complaints of painful raw lesions all over the body for 6 months, burning sensation of eyes with redness, fever for 10 days. On Day 4 of admission, the patient was started on Injection Rituximab, and the patient had variations in ECG observed, complaint of fever, associated with chills, tachycardia and insomnia, observed on the very first day of use. Each form of HSR has its own set of characteristics, as well as its own course and management. In terms of a tailored and exact approach, the new proposed classification appears to have clinical implications. Skin tests are the first stage in the diagnostic process, and if they are negative, DPT should be performed if appropriate settings are available. As a result, the desensitisation strategy requires more awareness and acceptance.
Transcellular blood–brain barrier disruption in malaria-induced reversible brain edema
Authors: Jin Jessica , Ba Mame Aida , Wai Chi Ho , Mohanty Sanjib , Sahu Praveen K , Pattnaik Rajyabardhan , Pirpamer Lukas , Fischer Manuel , Heiland Sabine , Lanzer Michael , Frischknecht Friedrich , Mueller Ann-Kristin , Pfeil Johannes , Majhi Megharay , Cyrklaff Marek , Wassmer Samuel C , Bendszus Martin , Hoffmann Angelika
Published: March 2022

Brain swelling occurs in cerebral malaria (CM) and may either reverse or result in fatal outcome. It is currently unknown how brain swelling in CM reverses, as brain swelling at the acute stage is difficult to study in humans and animal models with reliable induction of reversible edema are not known. In this study, we show that reversible brain swelling in experimental murine CM can be induced reliably after single vaccination with radiation-attenuated sporozoites as proven by in vivo high-field magnetic resonance imaging. Our results provide evidence that brain swelling results from transcellular blood–brain barrier disruption (BBBD), as revealed by electron microscopy. This mechanism enables reversal of brain swelling but does not prevent persistent focal brain damage, evidenced by microhemorrhages, in areas of most severe BBBD. In adult CM patients magnetic resonance imaging demonstrate microhemorrhages in more than one third of patients with reversible edema, emphasizing similarities of the experimental model and human disease. Our data suggest that targeting transcellular BBBD may represent a promising adjunct therapeutic approach to reduce edema and may improve neurological outcome.
Pengaruh kombinasi perawatan luka dan latihan Range of Motion ekstremitas bawah terhadap penyembuhan ulkus diabetik pada pasien Diabetes Mellitus
Authors: Lailasari Maya , Yanto Arief , Mustofa Akhmad
Published: March 2022

Pasien DM beresiko terjadi kerusakan pada pembuluh darah. Ulkus diabetik merupakan salah satu gangguan pada ekstermitas bawah dari komplikasi makrovaskuler yang dapat berakhir dengan amputasi. Perawatan luka dan latihan range of motion (ROM) ekstermitas bawah mampu menyembuhkan ulkus diabetik. Studi kasus ini bertujuan untuk mengetahui pengaruh kombinasi perawatan luka dan latihan range of motion (ROM) ekstermitas bawah untuk penyembuhan ulkus diabetik pada pasien diabetes mellitus. Studi kasus ini menggunakan desain studi deskriptif dengan pendekatan proses asuhan keperawatan. Subyek studi kasus adalah pasien DM yang terdapat ulkus diabetik. Subjek studi didapatkan melalui tehnik purposive sampling. Hasil studi kasus menunjukan pengaruh tindakan perawatan luka dan ROM terhadap proses granulasi luka ulkus diabetikum. Hasil observasi ulkus diabetikum menunjukkan penurunan skor dari 32 pada hari pertama menjadi 27 pada observasi hari kedua. Pada hari ketiga pengukuran diketahui skor 20 turun menjadi 18 pada observasi hari berikutnya. Berdasarkan hasil studi kasus ini dapat disimpulkan bahwa terdapat pengaruh kombinasi tindakan perawatan luka dan latihan range of motion (ROM) ekstermitas bawah terhadap penyembuhan ulkus diabetik pada pasien diabetes melitus.
Aplikasi pemberian teh bunga Rosella terhadap penurunan tekanan darah pada penderita hipertensi
Authors: Isnaen Radika Zulfikha , Warsono Warsono
Published: March 2022

Hipertensi merupakan suatu keadaan dimana seseorang mengalami peningkatan tekanan darah diatas batas normal. Dimana tekanan sistolik diatas 140 mmHg dan tekanan diastolik diatas 90 mmHg, dan itu terjadi secara terus menerus lebih dari 1 periode. Menurunkan tekanan darah pada penderita hipertensi tidak hanya dengan terapi farmakologi, dapat juga menggunakan terapi non farmakologi. Banyak terapi non farmakologi yang dapat digunakan untuk menurunkan tekanan darah, salah satunya pemberian seduhan teh bunga rosella. Tujuan dilakukan aplikasi tersebut untuk menurunkan tekanan darah tinggi pada penderita hipertensi. Metode yang dilaksanakan pada penelitian ini adalah Descriptive study. Jumlah responden 2 orang menderita hipertensi, berjenis kelamin perempuan, berumur 35-60 tahun. Diberikan seduhan teh bunga rosella selama 7 hari setiap pagi hari sebelum sarapan sebanyak 3 kuntum bunga dalam 200 ml air. Hasil studi kasus menunjukkan adanya penurunan tekanan darah setelah responden diberikan terapi seduhan teh bunga rosella. Sehingga dapat disimpulkan bahwa seduhan teh bunga rosella dapat menurunkan tekanan darah tinggi pada penderita hipertensi.
Generalized Ulam-Hyers Stability Results of a Quadratic Functional Equation in Felbin’s Type Fuzzy Normed Linear Spaces
Authors: Rassias John Michale , Karthikeyan S. , Ganapathy G. , Suresh M. , Kumar T.R.K.
Published: March 2022

This paper presents the generalized Ulam-Hyers stability of the following quadratic functional equationF((x+y)/2 – z) + f(y+z)/2 – x) + f((z+x)/2 – y) = 3/4(f(z−x) + f(z−y) + f(x−y))in Felbin’s type fuzzy normed linear spaces (f-NLS) using direct and fixed point methods.
PRINSIP INVERSI SEISMIK
Authors: Munadi Suprayitno
Published: March 2022

Inversi Seismik (seismic invertion) menjadi sangat populer akhir-akhir ini sehubungan dengan pekerjaan karakterisasi reservoir dan perkiraan besar cadangan migas dari lapangan yang jumlah sumurnya masih sedikit. Pada kedua jenis pekerjaan ini diperlukan peta distribusi porositas diluar sumur-sumur yang ada, dan hal ini didapat dari lintasan-lintasan seismik yang melingkupi lapangan yang bersangkutan. Data Seismik adalah data amplitudo gelombang sewaktu menjalar kedalam lapisan-lapisan batuan bawah permukaan, data amplitudo ni perlu diubah menjadi data kecepatan.
PENGARUH PENGGUNAAN LCO SEBAGAI KOMPONEN MINYAK SOLAR TERHADAP SIFAT-SIFAT FISIKA/KIMIA MINYAK SOLAR
Authors: Yuliarita Emi
Published: March 2022

Meningkatnya populasi kendaraan bermotor bermesin diesel di Indonesia, dan ditambah dnegan banyaknya industri-industri yang benyak menggunakan minyak solar sebagai bahan bakarnya, menyebabkan kebutuhan minyak solar dalam negeri meningkat dari tahun ke tahun. sementara itu persediaan minyak solar dalam negeri tidak mencukupi sehingga untuk memenuhi kebutuhan tersebut Indonesia terpaksa mengimpor minyak solar.
ANALISA KONSUMSI BAHAN BAKAR KENDARAAN BERMOTOR BENSIN DIATAS CHASSIS DYNAMOMETER
Authors: Puppung Pallawagau La
Published: March 2022

Dalam perjalanan setiap pemakai kendaraan selalu menginginkan agar ia dapat berjalan dengan lancar di jalan raya. Kendaraannnya dapat melaju dengan kecepatan tinggi sehingga dapat sampai ketujuan dalam waktu yang singkat. Namun kenyataan berbeda dengan harapan, terutama dikota-kota besar kendaraan merayap pada jam-jam sibuk. Kondisi operasi mesin stop dan jalan terjadi kendaraan berjalan dengan sangat lambatpada kecepatan antara 0 sampai dengan 20 km per jam dengan posisi gigi persneling 1 sampai 2.