bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictive factors for inadequate bowel preparation using low-volume polyethylene glycol (PEG) plus ascorbic acid for an outpatient colonoscopy
Authors: Shin Seung Yong , Ga Kyeong Seon , Kim In Young , Park Yoo Mi , Jung Da Hyun , Kim Jie-Hyun , Youn Young Hoon , Park Hyojin , Park Jae Jun
Published: December 2019

Low-volume polyethylene glycol (PEG) plus ascorbic acid solutions are widely used for bowel cleansing before colonoscopy. This study aimed to investigate the pre-endoscopic predictive factors for inadequate preparation in subjects receiving low-volume PEG plus ascorbic acid. A prospective study was performed at Gangnam Severance Hospital, Korea, from June 2016 to December 2016. All participants received low-volume PEG plus ascorbic acid solutions for outpatient colonoscopy. The split-dose bowel preparation was administered in subject with morning colonoscopy while same day bowel preparation was used for afternoon colonoscopy. 715 patients were enrolled (mean age 56.1 years, 54.4% male), of which 138 (19.3%) had an inadequate bowel preparation. In multivariable analysis, cirrhosis (OR 4.943, 95% CI 1.191–20.515), low (less than 70%) compliance for three-day low-residual diet (OR 2.165, 95% CI 1.333–3.515), brown liquid rectal effluent (compared with clear or semi-clear effluent) (OR 7.604, 95% CI, 1.760–32.857), and longer time interval (≥2 hours) between last defecation and colonoscopic examination (OR 1.841, 95% CI, 1.190–2.849) were found as an independent predictors for inadequate preparation. These predictive factors may be useful in guiding additional intervention to improve quality of bowel preparation.
An Effect of Chronic Stress on Prospective Memory via Alteration of Resting-State Hippocampal Subregion Functional Connectivity
Authors: Chen Jierong , Wei Zhen , Han Hongying , Jin Lili , Xu Chuanyong , Dong Dan , Lu Jianping , Wan Guobin , Peng Ziwen
Published: December 2019

The alteration of hippocampal function by chronic stress impairs higher order cognitive functions such as prospective memory (PM). However, how chronic stress affects hippocampal subregions related to PM remains largely unknown. In this study, the altered functional network of hippocampal subregions related to PM in chronic stress was explored. College students (N = 21) completed PM tasks and resting-state functional magnetic resonance imaging scans one month prior to (baseline) and during the final examination week (chronic stress). Hippocampal subregions’ seed-based functional connectivity (FC) and PM were compared between baseline and chronic stress. PM performance declined in chronic stress. The FC of the cornu ammonis 2, 3 and dentate gyrus (CA23DG) with the bilateral caudate and precuneus was increased in chronic stress, while the FC of the subicular complex (SUBC) with the left middle frontal gyrus, the left inferior parietal gyrus and the right supramarginal gyrus was decreased. There was a negative correlation between PM performance and the FC of hippocampal subregions. We found chronic stress impairs PM by decreasing the FC of SUBC and increasing the FC of CA23DG. These findings suggest functional changes in hippocampal subregion networks as a mechanism underlying the impairment of PM in chronic stress.
An In Vivo Mouse Model of Pelvic Recurrence of Human Colorectal Cancer
Authors: Yamamoto Masashi , Taniguchi Kohei , Masubuchi Shinsuke , Tominaga Tomo , Inomata Yosuke , Miyamoto Akiko , Ishizuka Taka-Aki , Murakami Takashi , Osumi Wataru , Hamamoto Hiroki , Tanaka Keitaro , Okuda Junji , Uchiyama Kazuhisa
Published: December 2019

Pelvic recurrence of colorectal cancer is a crucial problem because radical surgery can lead to excessive invasion. Novel therapeutic strategies are required instead of surgery. However, there are few suitable models because of the difficulty in transplanting and observing tumors in the pelvis. We have established an appropriate injection site suitable for the establishment of colorectal cancer pelvic recurrence that allows for the observation of tumor growth. DLD-1 cells stably expressing luciferase (DLD-1 clone#1-Luc) were inoculated into various points of female BALB/c nude mice and the engrafted cells were analyzed with an imaging system employing bioluminescent signals and computed tomography. Weekly analysis with the imaging system showed that a triangular area defined by the vagina, the anus, and the ischial spine was suitable for the engraftment of pelvic tumors. The imaging system was able to detect the engrafted tumor 7 days after the inoculation of cells. Weight loss was observed in our model, and overall survival was 21–42 days. Tumor involvement of adjacent organs was detected histopathologically, as is the case in the clinical situation. These findings suggest that this model is valid for evaluations of the therapeutic effects of novel treatments under development. It is hoped that this model will be used in preclinical research.
Rapid, CRISPR-Based, Field-Deployable Detection Of White Spot Syndrome Virus In Shrimp
Authors: Sullivan Timothy J. , Dhar Arun K. , Cruz-Flores Roberto , Bodnar Andrea G.
Published: December 2019

Rapid, sensitive, point-of-care diagnostics are critical for managing infectious diseases. Here we adapt the CRISPR-based SHERLOCK method to develop a rapid, accurate, single copy detection assay for White Spot Syndrome Virus, the most devastating virus impacting global shrimp aquaculture. Further, we combine paper matrix nucleic acid extraction and lateral flow colorimetric reporting to create a fully field-deployable, next-generation diagnostic with potential to transform veterinary pathology, disease ecology, and animal production.
Identification of miR-328-3p as an endogenous reference gene for the normalization of miRNA expression data from patients with Diabetic Retinopathy
Authors: Prado Marcelle SanJuan Ganem , de Goes Thaline Cunha , de Jesus Mirthz Lemos , Mendonça Lucilla Silva Oliveira , Nascimento Jadson Santos , Kaneto Carla Martins
Published: December 2019

Diabetic Retinopathy, the main cause of visual loss and blindness among working population, is a complication of Diabetes mellitus (DM), which has been described as a major public health challenge, so it is important to identify biomarkers to predict and to stratify patient´s possibility for developing DR. MicroRNAs (miRNAs) are small non-coding RNA molecules that have showed to be promising disease biomarkers and association of miRNAs with the possibility to develop DR has been reported. However, evaluating miRNA expression involves normalization of RT-qPCR data using internal reference genes that should be properly determined, considering their impact on expression levels calculation and, until date, there is no unanimity on reference miRNAs for the investigation of circulating miRNAs in DR. We aimed to estimate the appropriateness of a group of miRNAs as normalizers to identify which might be considered steady internal reference genes in expression studies on DR plasma samples. Expression levels of candidates were analyzed in 60 healthy controls, 48 DM without DR patients and 62 DR patients with two statistical tools: NormFinder and RefFinder. MiR-328-3p was the most stable gene and we also investigated the effect of gene normalization, demonstrating that different normalization strategies have important implications for accurate data interpretation.
Generation of polarization singularities with geometric metasurfaces
Authors: Zhang Yuchao , Yang Xiaodong , Gao Jie
Published: December 2019

The polarization singularities are directly generated by using plasmonic metasurfaces with the geometric phase profiles designed to form the Poincaré beams. Different morphologies of polarization topological structures of lemon, star, monstar, spiral, dipole and quadrupole are created by the superpositions of Laguerre–Gauss modes with different orders under orthogonal circular or linear polarization basis. The polarization ellipse patterns and topological features of the produced optical vector fields are analyzed to reveal the properties of the polarization singularities of C-points and L-lines, and the orbital angular momentum states are also measured. The demonstrated polarization singularities generated from the geometric metasurfaces will promise many potential applications related to optical polarization imaging, metrology, optical trapping and quantum information processing.
Diffusion-weighted Renal MRI at 9.4 Tesla Using RARE to Improve Anatomical Integrity
Authors: Periquito Joāo dos Santos , Paul Katharina , Huelnhagen Till , Ku Min-Chi , Ji Yiyi , Cantow Kathleen , Gladytz Thomas , Grosenick Dirk , Flemming Bert , Seeliger Erdmann , Waiczies Sonia , Niendorf Thoralf , Pohlmann Andreas
Published: December 2019

Diffusion-weighted magnetic resonance imaging (DWI) is a non-invasive imaging technique sensitive to tissue water movement. By enabling a discrimination between tissue properties without the need of contrast agent administration, DWI is invaluable for probing tissue microstructure in kidney diseases. DWI studies commonly make use of single-shot Echo-Planar Imaging (ss-EPI) techniques that are prone to suffering from geometric distortion. The goal of the present study was to develop a robust DWI technique tailored for preclinical magnetic resonance imaging (MRI) studies that is free of distortion and sensitive to detect microstructural changes. Since fast spin-echo imaging techniques are less susceptible to B0 inhomogeneity related image distortions, we introduced a diffusion sensitization to a split-echo Rapid Acquisition with Relaxation Enhancement (RARE) technique for high field preclinical DWI at 9.4 T. Validation studies in standard liquids provided diffusion coefficients consistent with reported values from the literature. Split-echo RARE outperformed conventional ss-EPI, with ss-EPI showing a 3.5-times larger border displacement (2.60 vs. 0.75) and a 60% higher intra-subject variability (cortex = 74%, outer medulla = 62% and inner medulla = 44%). The anatomical integrity provided by the split-echo RARE DWI technique is an essential component of parametric imaging on the way towards robust renal tissue characterization, especially during kidney disease.
Interspecific competition among aphid parasitoids: molecular approaches reveal preferential exploitation of parasitized hosts
Authors: Ortiz-Martínez Sebastián , Pierre Jean-Sébastien , van Baaren Joan , Le Lann Cécile , Zepeda-Paulo Francisca , Lavandero Blas
Published: December 2019

When a guild of species exploit the same limited resources, interspecific competition induces the exclusion of inferior competitors, in which case, interspecific recognition mechanisms are needed. Here, we address resource partitioning and interspecific competition among three main solitary parasitoid species attacking the same host resource, the aphidSitobion avenaein wheat fields. Optimal host acceptance models predict that parasitoid species should prefer attacking unparasitized hosts when they are available in order to maximize their fitness, as already parasitized hosts are less valuable for laying eggs, especially for inferior competitors. Therefore, we expected the level of competition (multiparasitism) in the field to increase at low host density. By using a combination of taxonomical (determination) and molecular (PCR-based) approaches, we assessed the species of all parasitoid adults and immature stages within aphid hosts. Our results demonstrate that, early in the season, the multiparasitism rates were low, whereas they were high in the mid-late season, corresponding to an aphid density decrease over time. Moreover, parasitoid species could not have been exploiting host resources randomly and the better competitor,Aphidius ervi, seemed to be foraging preferentially on hosts already parasitized by the inferior competitorA.rhopalosiphi, even when unparasitized hosts were still available. This could be due to differences in their host detection capability, as species with a narrow host range may be better at detecting their hosts in comparison with species with a greater host range, such asA.ervi, with a greater host range within the guild. Our study suggests differences in the host exploitation of two prevalent parasitoid species through the main period of aphid colonization, which still allowed the coexistence of a third inferior competitor (A.rhopalosiphi) within the assemblage, in spite of some negative interactions (multiparasitism) and redundancies.
Dynamics and stabilization of the rumen microbiome in yearling Tibetan sheep
Authors: Wang Lei , Zhang Ke , Zhang Chenguang , Feng Yuzhe , Zhang Xiaowei , Wang Xiaolong , Wu Guofang
Published: December 2019

The productivity of ruminants depends largely on rumen microbiota. However, there are few studies on the age-related succession of rumen microbial communities in grazing lambs. Here, we conducted 16 s rRNA gene sequencing for bacterial identification on rumen fluid samples from 27 Tibetan lambs at nine developmental stages (days (D) 0, 2, 7, 14, 28, 42, 56, 70, and 360, n = 3). We observed thatBacteroidetesandProteobacteriapopulations were significantly changed during the growing lambs’ first year of life.Bacteroidetesabundance increased from 18.9% on D0 to 53.9% on D360. On the other hand,Proteobacteriaabundance decreased significantly from 40.8% on D0 to 5.9% on D360.Prevotella_1established an absolute advantage in the rumen after 7 days of age. The co-occurrence network showed that the different microbial of the rumen presented a complex synergistic and cumbersome relationship. A phylogenetic tree was constructed, indicating that during the colonization process, may occur a phenomenon in which bacteria with close kinship are preferentially colonized. Overall, this study provides new insights into the colonization of bacterial communities in lambs that will benefit the development of management strategies to promote colonization of target communities to improve functional development.
Probabilistic Assessment of Nerve Regeneration with Diffusion MRI in Rat Models of Peripheral Nerve Trauma
Authors: Manzanera Esteve Isaac V. , Farinas Angel F. , Pollins Alonda C. , Nussenbaum Marlieke E. , Cardwell Nancy L. , Kang Hakmook , Does Mark D. , Thayer Wesley P. , Dortch Richard D.
Published: December 2019

Nerve regeneration after injury must occur in a timely fashion to restore function. Unfortunately, current methods (e.g., electrophysiology) provide limited information following trauma, resulting in delayed management and suboptimal outcomes. Herein, we evaluated the ability of diffusion MRI to monitor nerve regeneration after injury/repair. Sprague-Dawley rats were divided into three treatment groups (sham = 21, crush = 23, cut/repair = 19) andex vivodiffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) was performed 1–12 weeks post-surgery. Behavioral data showed a distinction between crush and cut/repair nerves at 4 weeks. This was consistent with DTI, which found that thresholds based on the ratio of radial and axial diffusivities (RD/AD = 0.40 ± 0.02) and fractional anisotropy (FA = 0.53 ± 0.01) differentiated crush from cut/repair injuries. By the 12thweek, cut/repair nerves whose behavioral data indicated a partial recovery were below the RD/AD threshold (and above the FA threshold), while nerves that did not recover were on the opposite side of each threshold. Additional morphometric analysis indicated that DTI-derived normalized scalar indices report on axon density (RD/AD: r = −0.54, p < 1e-3; FA: r = 0.56, p < 1e-3). Interestingly, higher-order DKI analyses did not improve our ability classify recovery. These findings suggest that DTI may provide promising biomarkers for distinguishing successful/unsuccessful nerve repairs and potentially identify cases that require reoperation.
A 3D Printed Hanging Drop Dripper for Tumor Spheroids Analysis Without Recovery
Authors: Zhao Liang , Xiu Jidong , Liu Yang , Zhang Tianye , Pan Wenjie , Zheng Xiaonan , Zhang Xueji
Published: December 2019

Compared with traditional monolayer cell culture, the three-dimensional tumor spheroid has emerged as an essential in vitro model for cancer research due to the recapitulation of the architecture and physiology of solid human tumors. Herein, by implementing the rapid prototyping of a benchtop 3D printer, we developed a new strategy to generate and analyze tumor spheroids on a commonly used multi-well plate. In this method, the printed artifact can be directly mounted on a 96/384-well plate, enables hanging drop-based spheroid formation, avoiding the tedious fabrication process from micromechanical systems. Besides long-term spheroid culture (20 days), this method supports subsequent analysis of tumor spheroid by seamlessly dripping from the printed array, thereby eliminating the need for spheroids retrieval for downstream characterization. We demonstrated several tumor spheroid-based assays, including tumoroid drug testing, metastasis on or inside extracellular matrix gel, and tumor transendothelial (TEM) assay. Based on quantitative phenotypical and molecular analysis without any precarious retrieval and transfer, we found that the malignant breast cancer (MDA-MB-231) cell aggregate presents a more metastatic morphological phenotype than the non-malignant breast cancer (MCF-7) and colonial cancer (HCT-116) cell spheroid, and shows an up-regulation of epithelial-mesenchymal transition (EMT) relevant genes (fold change > 2). Finally, we validated this tumor malignancy by the TEM assay, which could be easily performed using our approach. This methodology could provide a useful workflow for expediting tumoroid modeled in vitro assay, allowing the “Lab-on-a-Cloud” scenario for routine study.
Habitat selection patterns of a species at the edge – case study of the native racer goby population in Central Europe
Authors: Kukuła Krzysztof , Ortyl Bernadetta , Bylak Aneta
Published: December 2019

Invasive alien species are regarded a nuisance. This extends into a lack of conservation efforts in their native range. As a consequence, conservation of e.g. range-edge populations is neglected. Gobiidae have many representatives of alien species in European freshwaters, and therefore they have a bad reputation. Objectives of this study were to: define the habitat selection patterns of a species at the edge, and examine the ontogenetic variation in its distributions, i.e. spatial distribution of different size classes. A racer goby Babka gymnotrachelus (syn. Neogobius gymnotrachelus) population was selected for the model. In numerous European river basins, Ponto-Caspian racer goby has been an invasive alien species of interest to researchers for many years. Recently, however, native populations of the species have been described in the Polish tributary of the upper Dniester River (Black Sea basin). We used habitat data and densities of racer goby to disentangle the habitat selection patterns of the species at a river reach at the edge of its native range. Evident preferences towards habitats with large submerged objects serving as hiding places were characteristic of the largest gobies. Adult, largest gobies were very likely to choose the ‘boulders’ site, while forcing smaller individuals to occupy places with faster water current, i.e. less suitable in terms of saving energy. At a larger geographic scale, a significant portion of the submountain river was unsuitable for racer gobies. At the edge of the racer goby range, patches providing habitats suitable for the species were scarce and scattered. With regard to invasive populations, the presence of stony bottoms, quite certainly cannot be considered as a factor excluding potential colonisation by racer goby, and in submountain rivers it might be the preferred kind of bottom.
Reduced TRPM8 expression underpins reduced migraine risk and attenuated cold pain sensation in humans
Authors: Gavva Narender R. , Sandrock Robert , Arnold Gregory E. , Davis Michael , Lamas Edwin , Lindvay Chris , Li Chi-Ming , Smith Brian , Backonja Miroslav , Gabriel Kristin , Vargas Gabriel
Published: December 2019

Multiple genome-wide association studies have identified non-coding single-nucleotide variants (SNVs) near (e.g., rs10166942[C]) or within (rs17862920[T]) the TRPM8 gene that encodes a cold thermosensor is associated with reduced migraine risk. Furthermore, rs10166942[C]) and rs10166942[T]) are more prevalent in populations that reside in hotter and colder climates, respectively. Here we assessed whether these alleles affect TRPM8 expression in humans and human physiologic responses to cold challenge. Here we show that TRPM8 expression is decreased from the chromosome harboring the rs10166942[C] allele in the human dorsal root ganglia. Moreover, carriers of rs10166942[C] required significantly lower temperatures and longer duration of exposure to reach a cold pain threshold (CPTh), which correlated with decreased TRPM8 expression expected in the carriers. This study provides evidence for a genotype-dependent influence on cold pain sensation suggesting that carriers of the reduced migraine risk allele have reduced sensitivity to cold stimuli and that TRPM8 acts as a cold thermosensor and cold pain transducer in humans. Reduced TRPM8 expression and function underpins the migraine protection in carriers of rs10166942[C]; thus, the evaluation of TRPM8 antagonists as migraine therapeutics is warranted. Furthermore, these results provide mechanistic insights for evolutionary positive selection of rs10166942[T] allele in adaptation along latitudinal cline to colder climates.
Premotor dorsal white matter integrity for the prediction of upper limb motor impairment after stroke
Authors: Boccuni Leonardo , Meyer Sarah , D’cruz Nicholas , Kessner Simon S. , Marinelli Lucio , Trompetto Carlo , Peeters André , Van Pesch Vincent , Duprez Thierry , Sunaert Stefan , Feys Hilde , Thijs Vincent , Nieuwboer Alice , Verheyden Geert
Published: December 2019

Corticospinal tract integrity after stroke has been widely investigated through the evaluation of fibres descending from the primary motor cortex. However, about half of the corticospinal tract is composed by sub-pathways descending from premotor and parietal areas, to which damage may play a more specific role in motor impairment and recovery, particularly post-stroke. Therefore, the main aim of this study was to investigate lesion load within corticospinal tract sub-pathways as predictors of upper limb motor impairment after stroke. Motor impairment (Fugl-Meyer Upper Extremity score) was evaluated in 27 participants at one week and six months after stroke, together with other clinical and demographic data. Neuroimaging data were obtained within the first week after stroke. Univariate regression analysis indicated that among all neural correlates, lesion load within premotor fibres explained the most variance in motor impairment at six months (R2 = 0.44,p < 0.001). Multivariable regression analysis resulted in three independent, significant variables explaining motor impairment at six months; Fugl-Meyer Upper Extremity score at one week, premotor dorsal fibre lesion load at one week, and age below or above 70 years (total R2 = 0.81;p < 0.001). Early examination of premotor dorsal fibre integrity may be a promising biomarker of upper limb motor impairment after stroke.
Infrared spectra of micro-structured samples with microPhotoacoustic spectroscopy and synchrotron radiation
Authors: Michaelian Kirk H. , Frogley Mark D. , Cinque Gianfelice , Quaroni Luca
Published: December 2019

Diffraction limited infrared microspectroscopy and hyperspectral mapping have been achieved for optically challenging samples using novel photoacoustic microscopy and synchrotron radiation.
Multimodal detection and analysis of a new type of advanced Heinz body-like aggregate (AHBA) and cytoskeleton deformation in human RBCs
Authors: Bulat Katarzyna , Dybas Jakub , Kaczmarska Magdalena , Rygula Anna , Jasztal Agnieszka , Szczesny-Malysiak Ewa , Baranska Malgorzata , Wood Bayden R. , Marzec Katarzyna M.
Published: December 2019

A new type of aggregate, formed in human red blood cells (RBCs) in response to glutaraldehyde treatment, was discovered and analyzed with the classical and advanced biomolecular imaging techniques.
Influence of buried oxide layers of nanostructured SOI surfaces on matrix-free LDI-MS performances
Authors: Hamdi Abderrahmane , Hosu Ioana Silvia , Coffinier Yannick
Published: December 2019

In this paper, we report on the nanostructuration of the silicon crystalline top layer of different “home-made” SOI substrates presenting various buried oxide (BOx) layer thicknesses.
Dextran-based tube-guides for the regeneration of the rat sciatic nerve after neurotmesis injury
Authors: Pinho Ana Catarina , Vieira Branquinho Mariana , Alvites Rui Damásio , Fonseca Ana Clotilde , Caseiro Ana Rita , Santos Pedrosa Sílvia , Luís Ana Lúcia , Pires Isabel , Prada Justina , Muratori Luísa , Ronchi Giulia , Geuna Stefano , Santos José Domingos , Maurício Ana Colette , Serra Arménio Coimbra , Coelho Jorge Fernando Jordão
Published: December 2019

Nerve tube-guides based on dextran and poly(ε-caprolactone) were successfully used in the recovery of a neurotmesis injury in rat model.
PD-L1-targeted microbubbles loaded with docetaxel produce a synergistic effect for the treatment of lung cancer under ultrasound irradiation
Authors: Li Tiankuan , Hu Zhongqian , Wang Chao , Yang Jian , Zeng Chuhui , Fan Rui , Guo Jinhe
Published: December 2019

Immunotherapy is gradually becoming as important as traditional therapy in the treatment of cancer, but adverse drug reactions limit patient benefits from PD1/PD-L1 checkpoint inhibitor drugs in the treatment of non-small cell lung cancer (NSCLC).
Ion transportation by Prussian blue nanoparticles embedded in a giant liposome
Authors: Uddin S. M. Nizam , Laokroekkiat Salinthip , Rashed Md. A. , Mizuno Shino , Ono Kenta , Ishizaki Manabu , Kanaizuka Katsuhiko , Kurihara Masato , Nagao Yuki , Hamada Tsutomu
Published: December 2019

A new type of artificial giant liposome incorporating ion transport channels and using nanoparticles of metal organic frameworks was demonstrated.
Cubic perovskite-type Sm0.3Sr0.7Nb0.08Co0.92O3−δ as a novel cathode material for intermediate temperature solid oxide fuel cells
Authors: Zhang Haizhou , Chen Gui , Tang LiLi
Published: December 2019

A cubic perovskite stabilized at room temperature is synthesized to show dramatic electro-catalysis activity for the oxygen reduction reaction.
How to achieve a highly selective yet simply available vanadium phosphorus oxide-based catalyst for sustainable acrylic acid production via acetic acid-formaldehyde condensation
Authors: Liu Jun , Wang Pengcheng , Xu Peiwen , Xu Zhijia , Feng Xinzhen , Ji Weijie , Arandiyan Hamidreza , Au Chak-Tong
Published: December 2019

A series of unsupported and supported vanadium phosphorus oxide catalysts were prepared by employing a new strategy, which significantly reduced the complexity of catalyst preparation.
Chemical-biology approaches to probe DNA and RNA G-quadruplex structures in the genome
Authors: Raguseo Federica , Chowdhury Souroprobho , Minard Aisling , Di Antonio Marco
Published: December 2019

G-quadruplexes are nucleic-acids secondary structures that can be formed under physiological conditions. In this review, we critically present the most relevant chemical-biology methods to probe the biological functions of G-quadruplex structures.
Organic–inorganic hybrid (CH3NH3)2FeCuI4Cl2 and (CH3NH3)2InCuI6 for ultraviolet light photodetectors
Authors: Tao Siwen , Chen Yan , Cui Jiawen , Zhou Huawei , Yu Ning , Gao Xiaorui , Cui Shuting , Yuan Cang , Liu Meiqian , Wang Miaomiao , Wang Xiaojun , Gong Haoyu , Li Yanmin , Liu Tian , Sun Xun , Yin Jie , Zhang Xianxi , Wu Mingxing
Published: December 2019

In this study, we fabricate photodetector device based on organic–inorganic hybrid (CH3NH3)2FeCuI4Cl2 (MA2FeCuI4Cl2) and (CH3NH3)2InCuI6 (MA2InCuI6) for the first time.
ZnSe/CdSe core–shell nanoribbon arrays for photocatalytic applications
Authors: Sun Chengcheng , Li Tingting , Wen Weijia , Luo Xiangdong , Zhao Lijuan
Published: December 2019

Core–shell structures can improve the properties of materials due to their special structure and have attracted considerable attention for their applications in many fields.
Metal–organic framework tethering pH- and thermo-responsive polymer for ON–OFF controlled release of guest molecules
Authors: Nagata Shunjiro , Kokado Kenta , Sada Kazuki
Published: December 2019

Metal–organic framework tethering pH- and thermo-responsive polymer underwent ON–OFF controlled release of the included guest molecules.
Direct evidence of the key role of UV-formed peroxide species in photocatalytic gas–solid oxidation in air on anatase TiO2particles
Authors: Subbotina Irina Rudol’fovna , Barsukov Denis Valer’evich
Published: December 2019

Surface peroxide species are key intermediates of photocatalytic oxidation at the TiO2adsorbed water–gas interface.
Attack of hydroxyl radicals to α-methyl-styrene sulfonate polymers and cerium-mediated repair via radical cations
Authors: Nolte Tom M. , Nauser Thomas , Gubler Lorenz
Published: December 2019

Reaction between OH˙ radicals and α-methylstyrene sulfonate oligomers leads to radical cations which can be reduced by CeIII ions.
A heterojunction photocatalyst constructed by the modification of 2D-CeO2 on 2D-MoS2 nanosheets with enhanced degrading activity
Authors: Ji Rong , Zhu Zhi , Ma Wei , Tang Xu , Liu Yang , Huo Pengwei
Published: December 2019

A new 2D/2D heterojunction of MoS2/CeO2 is successfully prepared by a facile hydrothermal method.
A new synthesis of porphyrins via a putative trans-manganese(iv)-dihydroxide intermediate
Authors: Mondal Sruti , Sahu Kasturi , Patra Bratati , Jena Subhrakant , Biswal Himansu S. , Kar Sanjib
Published: December 2019

An efficient, milder (occurs at RT), scalable, and environmentally benign methodology for the facile synthesis of porphyrin derivatives without using quinone based oxidants has been developed.
Multi-dimensional templated synthesis of hierarchical Fe2O3/NiO composites and their superior ethanol sensing properties promoted by nanoscale p–n heterojunctions
Authors: Dong Shuwen , Wu Di , Gao Wenyuan , Hao Hongshun , Liu Guishan , Yan Shuang
Published: December 2019

Hierarchical Fe2O3/NiO composites, constructed from multi-dimensional building blocks, show high ethanol sensing performance due to the well-distributed nanoscale p–n heterojunctions.
Substituent effects on the electronic structures of sandwich compounds: new understandings provided by DFT-assisted laser ionization spectroscopy of bisarene complexes
Authors: Ketkov Sergey
Published: December 2019

High-resolution threshold ionization spectroscopy reveals new aspects of substituent effects in transition-metal sandwich complexes.
MoP supported on reduced graphene oxide for high performance electrochemical nitrogen reduction
Authors: Zhou Yan , Yu Xinping , Sun Fengchao , Zhang Jun
Published: December 2019

MoP nanoseeds grown on rGO for high-performance electrocatalytic nitrogen fixation.
Multi-potential-step chronocoulospectrometry for electrocatalytic water oxidation by a mononuclear ruthenium aquo complex immobilized on a mesoporous ITO electrode
Authors: Tsubonouchi Yuta , Honta Junichiro , Sato Taisei , Mohamed Eman A. , Zahran Zaki N. , Saito Kenji , Yui Tatsuto , Yagi Masayuki
Published: December 2019

A new Ru complex was synthesized to investigate electrocatalytic water oxidation on a mesoporous ITO electrode using multi-potential-step chronocoulospectrometry.
Is density functional theory accurate for lytic polysaccharide monooxygenase enzymes?
Authors: Larsson Ernst D. , Dong Geng , Veryazov Valera , Ryde Ulf , Hedegård Erik D.
Published: December 2019

The lytic polysaccharide monooxygenase (LPMO) enzymes boost polysaccharide depolymerization through oxidative chemistry, which has fueled the hope for more energy-efficient production of biofuel.
Using frustrated Lewis pairs to explore C–F bond activation
Authors: Briceno-Strocchia Alvaro I. , Johnstone Timothy C. , Stephan Douglas W.
Published: December 2019

Our interest in C–F bond activation prompted an investigation of the reactions of PhC(O)CF3 with a superbasic proazaphosphatrane (Verkade's base) and a corresponding FLP.
Nickel enrichment of next-generation NMC nanomaterials alters material stability, causing unexpected dissolution behavior and observed toxicity to S. oneidensis MR-1 and D. magna
Authors: Buchman Joseph T. , Bennett Evan A. , Wang Chenyu , Abbaspour Tamijani Ali , Bennett Joseph W. , Hudson Blake G. , Green Curtis M. , Clement Peter L. , Zhi Bo , Henke Austin H. , Laudadio Elizabeth D. , Mason Sara E. , Hamers Robert J. , Klaper Rebecca D. , Haynes Christy L.
Published: December 2019

Nickel-enriched lithium nickel manganese cobalt oxide, an increasingly used complex metal oxide, has unexpected dissolution behavior and impacts on two model environmental organisms.
Ultra-small CoOx/GO catalyst supported on ITO glass obtained by electrochemical post-treatment of a redox-active infinite coordination polymer: a portable reactor for real-time monitoring of catalytic oxidative degradation of colored wastewater
Authors: You Xinrui , Huang Chunyu , Huang Wei , Shi Guoyue , Deng Jingjing , Zhou Tianshu
Published: December 2019

Ultra-small CoOx/GO on ITO glass obtained by electrochemical polarization of a Co-ICP and its application in catalytic oxidative degradation of colored wastewater.
Energetically self-sustaining treatment of swine wastewater in a microbial electrochemical technology-centered hybrid system
Authors: Wang Haiman , Miao Zhuang , Li Yafeng , He Weihua , Qu Youpeng , Feng Yujie
Published: December 2019

A MES-centered hybrid system was developed with well-matched current generation, efficient organic matter removal and subsequent nitrogen removal.
A multiscale modelling approach to elucidate the mechanism of the oxygen evolution reaction at the hematite–water interface
Authors: Sinha V. , Sun D. , Meijer E. J. , Vlugt T. J. H. , Bieberle-Hütter A.
Published: December 2019

A novel multiscale model to elucidate the mechanism of the oxygen evolution reaction at the hematite–water interface.
Enhancing the electrocatalytic activity of CoO for the oxidation of 5-hydroxymethylfurfural by introducing oxygen vacancies
Authors: Huang Xin , Song Jinliang , Hua Manli , Xie Zhenbing , Liu Shuaishuai , Wu Tianbin , Yang Guanying , Han Buxing
Published: December 2019

The activity of CoO for the electrocatalytic oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid could be significantly enhanced by introducing oxygen vacancies via Se doping.
Introducing the Tishchenko reaction into sustainable polymer chemistry
Authors: Ren Tianhua , Chen Qin , Zhao Changbo , Zheng Qiang , Xie Haibo , North Michael
Published: December 2019

The combination of the Williamson and Tishchenko reactions produced a series of new α,ω-diene functionalized carboxylic ester, by which serials of polyesters have been prepared successfully.
Ultrafast star-shaped acoustic micromixer for high throughput nanoparticle synthesis
Authors: An Le Nguyen Hoai , Deng Hao , Devendran Citsabehsan , Akhtar Nabila , Ma Xiaoman , Pouton Colin , Chan Hak-Kim , Neild Adrian , Alan Tuncay
Published: December 2019

Ultrafast acoustic micromixers can effectively homogenize fluids in 4 milliseconds, at 8 ml min−1 flowrates providing a 50-fold improvement in throughput.
Conversion of amino acids to aryl/heteroaryl ethanol metabolites using human CYP2D6-expressing live baker's yeast
Authors: Bhardwaj Monika , Chib Shifali , Kaur Loveleena , Kumar Amit , Chaudhuri Bhabatosh , Malik Fayaz , Vishwakarma Ram A. , Saran Saurabh , Mukherjee Debaraj
Published: December 2019

Biotransformation of amino acids into aryl/heteroaryl ethanol metabolites using human CYP2D6 for developing a potential anti-depressant agent.
An epigrammatic status of the ‘azole’-based antimalarial drugs
Authors: Sharma Mousmee , Prasher Parteek
Published: December 2019

The review presents an epigrammatic collation of the contemporary antimalarial therapeutics based on various ‘azole’-based motifs for targeting both the drug-resistant and drug-susceptiblePlasmodiumparasite.
An efficient down conversion luminescencent probe based on a NaGdF4:Eu3+/Ce3+ nanophosphor for chemical sensing of heavy metal ions (Cd2+, Pb2+ and Cr3+) in waste water
Authors: Tashi Lobzang , Kumar Manesh , ul Nisa Zaib , Nelofar Nargis , Sheikh Haq Nawaz
Published: December 2019

Eu3+ doped and Eu3+/Ce3+ co-doped NaGdF4 nanophosphors are fabricated via a facile hydrothermal route. The codoped counterpart is demonstrated for efficient photoluminescence sensing of heavy metal ions (Cd2+, Pb2+ and Cr3+) present in industrial effluents.
The dual delivery of growth factors and antimicrobial peptide by PLGA/GO composite biofilms to promote skin-wound healing
Authors: Zhang Ziyan , Zhou Shicheng , Zhang Yanzhe , Wu Dankai , Yang Xiaoyu
Published: December 2019

Biodegradable biomaterials coated with active factors are effective medical devices to promote wound healing.
A molecularly engineered near-infrared-light-emitting electrochemical cell (NIR-LEC)
Authors: Nemati Bideh Babak , Shahroosvand Hashem
Published: December 2019

The simple architecture of the light-emitting electrochemical cell based on a new ruthenium pyridine–phenanthroimidazole emitter was fabricated using ITO and Ga:In as the electrodes.
Reversible reconfiguration of high-order DNA nanostructures by employing G-quartet toeholds as adhesive units
Authors: Chan Miu Shan , Leung Hoi Man , Wong Sze Wing , Lin Zihong , Gao Qi , Chang Tristan Juin Han , Lai King Wai Chiu , Lo Pik Kwan
Published: December 2019

Reversible reconfiguration of polymeric DNA nanostructures by using a G-quadruplex-mediated assembly strategy.
Parallel weight update protocol for a carbon nanotube synaptic transistor array for accelerating neuromorphic computing
Authors: Kim Sungho , Lee Yongwoo , Kim Hee-Dong , Choi Sung-Jin
Published: December 2019

A selective and parallel weight update protocol is demonstrated for energy-efficient learning process in neuromorphic computing.
Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac)
Authors: Chidwick Harriet S. , Fascione Martin A.
Published: December 2019

The nonulosonic acid sugar pseudaminic acid, Pse5Ac7Ac, is present on the surface of a number of human pathogens, herein we review the mechanistic and structural characterisation of the enzymes responsible for its biosynthesis in bacteria.
An effective reagent to functionalize alcohols with phosphocholine
Authors: Xu Lianyan L. , Berg Lawrence J. , Jamin Keith D. , Townsend Steven D.
Published: December 2019

A one-pot, three-step sequence has been developed to synthesize phosphocholine derivatives. The method has been applied to the synthesis of several biologics such as the anti-parasitic drug miltefosine.
Synthesis and complex self-assembly of amphiphilic block copolymers with a branched hydrophobic poly(2-oxazoline) into multicompartment micelles, pseudo-vesicles and yolk/shell nanoparticles
Authors: Daubian Davy , Gaitzsch Jens , Meier Wolfgang
Published: December 2019

A new PEO-b-PEHOx amphiphilic diblock copolymer was achieved which unlocked new complex self-assembled structures. Thanks to its hydrophobic oxazoline block with a long branched side chain, EHOx, various potent structures were obtained.
Stereoselective copolymerization of 4-(N,N-diphenylamino)styrene and isoprene by a C5H5-ligated scandium catalyst: synthesis of amino-functionalized crystalline styrenic thermoplastic elastomers
Authors: Guo Fang , Jiang Lei , Diao Kaiying , Hou Zhaomin
Published: December 2019

Amino-functionalized crystalline styrenic thermoplastic elastomers were prepared by carrying out stereoselective copolymerizations of 4-(N,N-diphenylamino)styrene and isoprene with the use of a C5H5-ligated scandium catalyst.
Enhanced hydrogen generation performance of CaMg2-based materials by ball milling
Authors: Ma Miaolian , Chen Kang , Jiang Jun , Yang Xusheng , Wang Hui , Shao Huaiyu , Liu Jiangwen , Ouyang Liuzhang
Published: December 2019

The hydrolysis properties of CaMg2-based materials can be enhanced via tailoring the milling durations or/and doping with the Ni element.
Hydrothermally synthesized chalcopyrite platelets as an electrode material for symmetric supercapacitors
Authors: Sahoo Surjit , Pazhamalai Parthiban , Mariappan Vimal Kumar , Veerasubramani Ganesh Kumar , Kim Nam-Jin , Kim Sang-Jae
Published: December 2019

A novel chalcopyrite (CuFeS2) platelet like open-pored micro-flower nanostructure investigated as an electrode material for supercapacitors.
Cyclocondensation of coumarin-3-thioformates with 3-hydroxyoxindoles and 3-aminooxindoles for the synthesis of spiro-fused pentaheterocyclic compounds
Authors: Lei Chuan-Wen , Zhang Chuan-Bao , Wang Zhen-Hua , Xie Ke-Xin , Zhao Jian-Qiang , Zhou Ming-Qiang , Zhang Xiao-Mei , Xu Xiao-Ying , Yuan Wei-Cheng
Published: December 2019

A range of spiro-fused pentaheterocyclic compounds including spiro-butyrolactoneoxindole[3,4-c]coumarins and spiro-butyrolactamoxindole[3,4-c]coumarins were smoothly obtained via tandem Michael addition-lactonization/lactamization process.
Low-cost uncooled MWIR PbSe quantum dots photodiodes
Authors: Qiu Jijun , Weng Binbin , McDowell Lance L. , Shi Zhisheng
Published: December 2019

A mid-wave infrared (MWIR) uncooled PbSe-QDs/CdS p–n heterojunction photodiode has been fabricated using a wet-chemical synthesis route.
UHPLC-MS metabolome based classification of umbelliferous fruit taxa: a prospect for phyto-equivalency of its different accessions and in response to roasting
Authors: Serag Ahmed , Baky Mostafa H. , Döll Stefanie , Farag Mohamed A.
Published: December 2019

First metabolome map for umbelliferous fruits secondary metabolites profiling via UHPLC-QToF/MS with scrutinizing its metabolome compositional changes incurred upon roasting.
Biorefinery of turmeric (Curcuma longa L.) using non-thermal and clean emerging technologies: an update on the curcumin recovery step
Authors: Landim Neves Maria Isabel , Strieder Monique Martins , Vardanega Renata , Silva Eric Keven , Meireles M. Angela A.
Published: December 2019

In this study, a biorefinery for the processing of turmeric (Curcuma longa L.) based on clean and emerging technologies has been proposed.
Nanozyme-based catalytic theranostics
Authors: Zhang Yanan , Jin Yiliang , Cui Haixia , Yan Xiyun , Fan Kelong
Published: December 2019

With its diverse physical–chemical properties and highly efficient enzyme-like activities, nanozymes have been widely used in various theranostics.
Real-time andin situobservation of structural evolution of giant block copolymer thin film under solvent vapor annealing by atomic force microscopy
Authors: Takano Kaori , Nyu Takashi , Maekawa Tatsuhiro , Seki Takashi , Nakatani Ryuichi , Komamura Takahiro , Hayakawa Teruaki , Hayashi Tomohiro
Published: December 2019

Real-time andin situobservation technique was proposed for ultra high molecular weight block copolymer thin films under solvent vapor annealing.
The efficient degradation of organic pollutants in an aqueous environment under visible light irradiation by persulfate catalytically activated with kaolin-Fe2O3
Authors: He Qianqian , Xie Chunsheng , Gan Dexin , Xiao Chun
Published: December 2019

Characterizations and properties of catalysts.
Equilibria and correlation of systems involving 1-hexyl-3-methylpyridinium trifluoromethanesulfonate
Authors: Corchero R. , Marcilla A. , Olaya M. M. , Carbonell-Hermida P. , Soto A.
Published: December 2019

The NRTL model is a useful tool to carry out the simultaneous correlation of all different equilibrium regions found in a phase diagram.
Degradation of OLED performance by exposure to UV irradiation
Authors: Kwon Sun-Kap , Baek Ji-Ho , Choi Hyun-Chul , Kim Seong Keun , Lampande Raju , Pode Ramchandra , Kwon Jang Hyuk
Published: December 2019

This paper reports the influence of UV radiation on the interface of a co-deposited EIL and Ag : Mg (10 : 1) cathode unit and pixel shrinkage.
Pot and time economies in the total synthesis of Corey lactone
Authors: Umekubo Nariyoshi , Suga Yurina , Hayashi Yujiro
Published: December 2019

The Corey lactone was synthesized by one-pot within 152 minutes from comercially available compounds using organocatalyst.
Durability of submerged hydrophobic surfaces
Authors: Varughese Sharon Mariam , Bhandaru Nandini
Published: December 2019

Study of change in surface morphology and wettability of biomimetic hydrophobic surfaces submerged in acidic, basic and neutral media for different durations over a prolonged period of time.
Human-tissue-inspired anti-fatigue-fracture hydrogel for a sensitive wide-range human–machine interface
Authors: Su Gehong , Cao Jie , Zhang Xueqian , Zhang Yulin , Yin Shuya , Jia Liyang , Guo Quanquan , Zhang Xinxing , Zhang Junhua , Zhou Tao
Published: December 2019

An effective and simple strategy is proposed to prepare a multifunctional hydrogel that shows ultra-stretchable (>2900%), anti-fatigue-fracture, and self-healable properties.
Intermetallic compound catalysts: synthetic scheme, structure characterization and catalytic application
Authors: Yang Yusen , Wei Min
Published: December 2019

This review summarizes and highlights the recent developments in the design, synthesis, and characterization of intermetallic compound catalysts and their potential applications in the heterogeneous catalytic field.
In situ exsolution of Ni particles on the PrBaMn2O5 SOFC electrode material monitored by high temperature neutron powder diffraction under hydrogen
Authors: Bahout Mona , Managutti Praveen B. , Dorcet Vincent , Le Gal La Salle Annie , Paofai Serge , Hansen Thomas C.
Published: December 2019

NiO has been incorporated into the Pr0.5Ba0.5MnO3−δ perovskite to produce in situ exsolved Ni-catalyst on the PrBaMn2O5 anode material upon heating under a hydrogen atmosphere.
Machine-learning-assisted screening of pure-silica zeolites for effective removal of linear siloxanes and derivatives
Authors: Lin Shiru , Wang Yekun , Zhao Yinghe , Pericchi Luis R. , Hernández-Maldonado Arturo J. , Chen Zhongfang
Published: December 2019

By a two-step computational process, namely Grand Canonical Monte Carlo (GCMC) simulations and machine learning (ML), we screened 50 959 hypothetical pure-silica zeolites and identified 230 preeminent zeolites with excellent adsorption performances.
A homojunction–heterojunction–homojunction scaffold boosts photocatalytic H2evolution over Cd0.5Zn0.5S/CoO hybrids
Authors: Zhao Haitao , Guo Luyan , Xing Chuanwang , Liu Heyuan , Li Xiyou
Published: December 2019

A hybrid photocatalyst was constructed based on twin crystal Cd0.5Zn0.5S with a homojunction containing M-CoO as the co-catalyst. The homojunction containing M-CoO is proved to be a more efficient co-catalyst than its pure phase counterparts.
Bifunctional nickel and copper electrocatalysts for CO2 reduction and the oxygen evolution reaction
Authors: Pan Hanqing , Barile Christopher J.
Published: December 2019

A bifunctional Ni–Cu2O electrode catalyzes both the reduction of CO2 and the oxidation of H2O.
A stable and high-energy hybrid supercapacitor using porous Cu2O–Cu1.8S nanowire arrays
Authors: Esfandiar Ali , Qorbani Mohammad , Shown Indrajit , Ojaghi Dogahe Badrosadat
Published: December 2019

The capacitance of Cu2O–Cu1.8S nanowires decorated with Cu1.8S polyhedra can reach 2.6 F cm−2 with a prominent rate capability of 62% at 80 mA cm−2.
Promoting nitrogen photofixation over a periodic WS2@TiO2 nanoporous film
Authors: Shi Li , Li Zhao , Ju Licheng , Carrasco-Pena Alejandro , Orlovskaya Nina , Zhou Haiqing , Yang Yang
Published: December 2019

WS2@TiO2 nanoporous films were fabricated by implanting WS2 nanosheets in TiO2 nanoporous films and show efficient photocatalytic N2 fixation.
Correction: Cathode materials for lithium–sulfur batteries: a practical perspective
Authors: Eftekhari Ali , Kim Dong-Won
Published: December 2019

Correction for ‘Cathode materials for lithium–sulfur batteries: a practical perspective’ by Ali Eftekhari et al., J. Mater. Chem. A, 2017, 5, 17734–17776.
Correction: Tungsten dichalcogenides (WS2, WSe2, and WTe2): materials chemistry and applications
Authors: Eftekhari Ali
Published: December 2019

Correction for ‘Tungsten dichalcogenides (WS2, WSe2, and WTe2): materials chemistry and applications’ by Ali Eftekhari et al., J. Mater. Chem. A, 2017, 5, 18299–18325.