bluuebunny/crossref_metadata_2025 huggingface dataset:
Recognition of English Vocabulary and Speech Corpus Based on Computer Image Processing
Authors: Sun Xiaohong
Published: August 2022

In order to solve the problem that the function and performance of traditional systems in English machine translation cannot meet the needs of intelligence, the author proposes an English vocabulary and speech corpus recognition system based on computer image processing. On the basis of designing the overall structure of the system, the hardware structure is designed by designing the server and translator. In the software design, the semantic features of the input English sentences in human-computer interaction are analyzed by using the enhanced algorithm, the decoding algorithm is designed according to the analysis results, and the English machine translation model is constructed. Experimental results show that when the number of sentences translated by this system is from 100 to 1000, the BLEU indicator keeps rising from 7 to 10. The English vocabulary and speech corpus recognition system based on computer image processing is more efficient.
Cleaning Quality Control Management of Medical Equipment in Hospital Disinfection Supply Room Based on Smart Medicine
Authors: Wu Meixia , Wang Qing , Cheng Zhuolin
Published: August 2022

With the continuous improvement of medical level, the demand for medical devices increases year by year, and it is necessary to track the quality and safety of medical devices. Establishing the cleaning quality control management of medical devices can not only reduce medical accidents and inhibit the spread of counterfeit or substandard medical devices but also help enterprises find the source of problems, determine the flow of the same batch of products, and warn relevant enterprises to take measures after the occurrence of problem products, and ultimately ensure the rights and interests of consumers. This study aims to study the cleaning quality control management of medical equipment in the hospital disinfection supply room based on smart medical care and proposes related concepts of smart medical care, as well as related theories of Internet of Things technology and medical equipment tracking system and related concepts of medical equipment cleaning. In this study, by comparing the cleaning compliance rates of the two groups of medical devices through smart medical care, it can be seen that 100% of the research group applying program-based management is significantly higher than 76.6% of the conventional management path. There was statistical significance in the data comparison between groups (

P
<
0.05

). Therefore, programmatic management is more targeted than conventional management paths.
Route Planning of Health Care Tourism Based on Computer Deep Learning
Authors: Wang Shiwei
Published: August 2022

With the continuous improvement of people’s living standards, the form of tourism is gradually changing. In the past two years, people’s demand for tourism has also changed from traditional ornamental tourism to wellness tourism, which has provided a development opportunity for rural tourism. At the same time, the government has also begun to focus on the development of tourism with rural characteristics to promote the development of rural areas. However, health tourism still has certain defects, and the development of rural planning is still advancing and improving. Leisure agriculture is an area where agriculture, tourism, and service industries intersect, and it is the link that maintains the common development of the three. Applying the concept of health tourism to the planning and design of leisure agricultural parks can make people satisfied in tourism. The pursuit of health and wellness also drives the development of the rural economy. With the progress of the economy and the continuous improvement of people’s living standards, the traditional travel mode is gradually changing towards the direction of informatization. The traditional way of travel-by-travel agencies planning travel routes is no longer the first choice for people to travel. On the one hand, the rapid development of the Internet brings convenience to people, and on the other hand, it also brings a lot of information to the public.
Clinical Study of Mobile Application- (App-) Based Family-Centered Care (FCC) Model Combined with Comprehensive Iron Removal Treatment in Children with Severe Beta Thalassemia
Authors: Chen Yuke , Huang Xiuping , Lu Qingmei , Lu Jian , Huang Xiaoxiao , Luo Yanni , Huang Fengxing
Published: August 2022

Background and Objective. Hemoglobinopathy is one of the most prevalent monogenic disorders in the world. Thalassemia is characterized by autosomal recessive deficiencies in hemoglobin production. The difficulties of iron overload caused by transfusions, which are the foundation of illness management in the majority of patients with severe thalassemia, may further worsen the clinical features. There are numerous obstacles and restrictions to the currently accessible conventional therapy for thalassemia. The purpose of the study is to investigate the clinical impact of the family-centered care (FCC) model based on a mobile application (app) in conjunction with comprehensive iron removal therapy for children with severe beta thalassemia. Methods. A retrospective study was conducted on the clinical records of 148 children diagnosed with severe beta thalassemia who were admitted to our hospital between October 2018 and September 2021. The patients were separated into two groups, a control group and an intervention group, with 74 cases in each group, according to the various care approaches. The basic treatment regimen was given to all of the children: deferoxamine mesylate combined with deferiprone. During treatment, the control group received routine care, and the intervention group adopted the FCC model based on a mobile app. The quality of life scale for children and adolescents (QLSCA) score, the family assessment device (FAD) score, the exercise of self-care agency scale (ESCA) score, and the medication compliance scale score were compared between the two groups. Results. The QLSCA score, ESCA score, and medication compliance scale score of the intervention group were significantly higher than those of the control group and showed a significant difference (intergroup effect:

F
=
198.400

, 259.200, and 129.800, all

P
<
0.001

). Scores in both groups increased over time (time effect:

F
=
19.350

, 40.830, and 12.130, all

P
<
0.001

), and there was an interaction effect between grouping and time (interaction effect:

F
=
3.937

, 12.020, and 5.028). The

P

values were 0.020, <0.001, and 0.007. The FAD score of the intervention group was significantly lower than that of the control group (intergroup effect:

F
=
177.200

,

P
<
0.001

). The FAD scores of both groups decreased over time (time effect:

F
=
7.921

,

P
=
0.005

). There was an interaction effect between groups and time (interaction effect:

F
=
5.206

,

P
=
0.006

). Conclusion. The application effect of the mobile app-based FCC model combined with the comprehensive iron removal treatment program in children with severe beta thalassemia is significant, which can significantly improve the quality of life, family function, self-care ability, and medication compliance of children, and has high clinical application value.
“Internet Plus” Sports Industry of New Business Development Model
Authors: Yang Xiaofang
Published: August 2022

In recent years, with the development of information technology, “internet plus” has become the main way to promote the development of sports industry, and keeping the sustainable development of sports has also become the most challenging topic in the sports field. In order to solve the sustainable development of sports industry, this paper analyzes the problems of traditional sports industry in product types, marketing models and management, and applies “internet plus” to sports industry, forming new industries such as Internet broadcasting, intelligent software and hardware, e-commerce, and e-sports, realizing humanized and intelligent products, diversified organizational forms, and innovative management models. Through the connotation and classification of “internet plus sports,” it integrates and analyzes the new format. The results show that the innovative development of new formats can be realized through product and business integration, product positioning optimization, and active industry guidance, and a “high+new” industrial structural development model can be formed. On the basis that the government and market mechanism do not conform to the economic development, through the optimization of collectivized industrial organization, a “collectivized” organizational model has been formed, and a new format of “internet plus” sports industry has been constructed. The research results have laid a solid theoretical foundation for the development of “internet plus sports.”
The Effect of Nursing Intervention on Patients with Inguinal Hernia and Its Influence on Self‐Management Ability
Authors: Zhang Ning , Miao Jingjing , Zheng Qiaona
Published: August 2022

Objective. To objectively evaluate the nursing quality of patients with inguinal hernia from the aspects of postoperative pain, self‐discipline, and complications, the application of medical data analysis and nursing intervention in patients with inguinal hernia was discussed. Methods. A total of 86 patients with inguinal hernia were selected, and the time distribution was from September 2020 to March 2021. The patients were divided into two groups: in the control group, there were 43 cases, 28 males and 15 females. There were 43 cases in the observation group, 25 males and 18 females. All selected subjects must sign the informed consent form and have the right to know the research content. The patients were diagnosed by abdominal ultrasound, and the demographic data and basic clinical data were recorded. Results. A total of 86 patients were divided into two groups in this study, of which 43 patients used a routine nursing path as the control group and the other 43 patients added medical data analysis and nursing intervention as the observation group on the basis of the routine nursing path. The postoperative pain, self‐discipline, complications, and patient satisfaction were compared, and the patients’ satisfaction in the experimental group was significantly higher than that in the control group, while serum swelling and urine retention were significantly lower than those in the control group (p < 0.05). Conclusion. According to the analysis of the routine nursing path and medical data, nursing intervention patients have more stable emotions and less postoperative pain. They can get out of bed early, reduce the occurrence of other complications, and improve the overall curative effect. Systematic nursing intervention can reduce the incidence of postoperative adverse reactions and complications. It is one of the ideal adjuvant treatments for inguinal hernia patients.
[Retracted] Hot Air Treatment Elicits Disease Resistance against Colletotrichum gloeosporioides and Improves the Quality of Papaya by Metabolomic Profiling
Authors: Liu Bo , Xue Meiling , Zhou Jiao , Zhang Hongxia , Ren Lili , Fan Jianting
Published: August 2022

Forced air heat treatment could induce defenses to protect fruit from pathogen attacks and has been applied as an alternative to methyl bromide for phytosanitary treatment before exportation. However, few studies were reported on the regulation mechanism of antifungal effect and delayed physiological disorders of papaya by heat treatment. Therefore, we aim to explore the fruit’s resistance to pathogens and the inhibition of physiological disorders by metabolomic profiling. In our study, papaya fruits were treated with 47.2°C for 30, 60, and 90 min by forced hot air treatment. The disease resistance against Colletotrichum gloeosporioides, quality parameters, and metabolites of papaya fruits were measured during 10 days of storage after heat treatment by metabolomic profiling. Papaya fruits after 30 and 60 min heat treatment had higher firmness, a delayed degreening and yellowing (lower a value) process, and a higher lightness (L) and hue angle (h) during storage. Heat treatment also delayed ripening, inhibiting the growth of C. gloeosporioides and softening of papaya. Metabolites and enzymes inhibited ROS scavenging, depressed ABA‐regulated respiratory, and activated phenylpropanoid metabolism. Our study provides a broad picture of fruit resistance to pathogens and the inhibition of physiological disorders by metabolomic profiling, which is induced by heat treatment.
Older Age and Abnormal Pulmonary Ventilation Function Do Not Increase the Risk of Pulmonary Hemorrhage Caused by CT-Guided Percutaneous Core Needle Biopsy
Authors: Yu Xuejuan , Li Chunhai , Wang Dexiang , Liu Bo , Jia Haipeng , Zhou Wei
Published: August 2022

Purpose. The aim of this study was to analyze the differences in risk factors for pulmonary hemorrhage in elderly and young patients with percutaneous computed tomography-guided needle biopsies (PCNBs). The correlations between the incidence of pulmonary hemorrhage and pulmonary function indicators before CT-guided PCNB were also discussed. Methods. Between January 2018 and December 2019, 1,100 consecutive patients underwent CT-guided PCNBs at Qilu Hospital. Both univariate and multivariate logistic regression analyses identified risk factors for hemorrhage. Results. The occurrence of pulmonary hemorrhage was 22.1% in elderly patients and was 22.6% in young patients. In elderly patients, pulmonary hemorrhage was significantly influenced by needle depth to the lesion and dwell time, while in young patients, pulmonary hemorrhage was independently associated with lesion size, needle depth to the lesion, and dwell time. However, pulmonary function parameters, including FVC (% pred), FEV1 (% pred), FEV1/FVC ratio (%), small airway function parameters (FEF50%, FEF75%, and FEF25–75%), and large airway function parameters (MVV, PEF, and FEF25%), were not risk factors for hemorrhage. Furthermore, the incidence of pulmonary hemorrhage was not associated with different types of pulmonary dysfunctions. The risk of pulmonary hemorrhage did not increase with the severity of pulmonary dysfunctions. Conclusions. In this study, age is no longer a risk factor in evaluating pulmonary hemorrhage. Longer needle depth to the lesion and longer dwell time were significantly high risk factors of hemorrhage in both elderly patients and young patients. Patients with severe pulmonary dysfunctions did not show increased risks of pulmonary hemorrhage here.
Effects and Safety of Traditional Chinese Medicine for Hidden Blood Loss after Total Hip Arthroplasty—A Systematic Review and Meta-Analysis
Authors: Yang Ze , Wang Xiang , Xu Zheyun , Xu Qike , Xia Yongliang , Ji Weifeng
Published: August 2022

Background. Hidden blood loss (HBL) after total hip arthroplasty (THA) would lead to many undesirable consequences. Traditional Chinese medicine (TCM) is now increasingly used for hidden blood loss. We performed this systematic review and meta-analysis to summarize the effect and safety of TCM treatment of HBL after THA. Methods. We searched PubMed, Embase, Cochrane Library, CNKI, VIP, WanFang, and CBM for the updated articles published from the inception of each database to May, 2022, among which results such as abstracts, comments, letters, reviews, and case reports were excluded. The efficacy and safety of TCM treatment of HBL after THA were synthesized and discussed by the outcomes of total blood loss (TBL), hidden blood loss (HBL), hemoglobin (Hb), and hematocrit (HCT), and the incidence of adverse reactions. Results. A total of 12 articles and 881 patients were included. There were 441 cases in the intervention group and 440 cases in the control group. Compared with the control group, the intervention group had more advantages in TBL (MD = −251.68, 95% CI = [−378.36, −125]; Z = 3.89,

P
<
0.00001

), HBL (MD = −159.64, 95% CI = [−252.56, −66.71]; Z = 3.37,

P
=
0.0008

), Hb (MD = 11.39, 95% CI = [7.35, 15.43]; Z = 5.53,

P
<
0.00001

), and HCT (MD = 2.87, 95% CI = [0.97, 4.78]; Z = 2.95,

P
=
0.003

), and had less incidence of adverse reactions (OR = −0.20, 95% CI = [−0.35, −0.05]; Z = 2.64,

P
=
0.008

). Conclusion. TCM has advantages in the efficacy and safety of treating hidden blood loss after THA. The strength of the evidence of the research results is limited by the quality of the included literature, and more high-quality RCTs are needed to confirm.
Clinical Significance of Negative Costimulatory Molecule PD-1/PD-L1 on Peripheral Blood Regulatory T Cell Levels among Patients with Pulmonary Tuberculosis
Authors: Yang Chenchen , Dai Fanchao , Pulati Rexiti , Jiao Yan , Xu Qian
Published: August 2022

Objective. This study aimed to investigate the expression and clinical significance of negative costimulatory molecules programmed death-1 (PD-1) and programmed death ligand 1 (PD-L1) on CD4+CD25+CD127low regulatory T cells (Tregs) in peripheral blood of patients with active pulmonary tuberculosis (TB). Methods. A total of 30 patients with active pulmonary TB and 20 healthy controls were enrolled. The proportions of peripheral blood CD4+CD25+CD127low Tregs and the expression of PD-1 and PD-L1 on CD4+CD25+CD127low Tregs were detected among active pulmonary TB patients using flow cytometry. The associations of proportions of CD4+CD25+CD127low Tregs with the demographic and clinical characteristics of active pulmonary TB patients were evaluated, and the correlation between PD-1/PD-L1 expression and proportions of peripheral blood CD4+CD25+CD127low Tregs was examined among patients with active pulmonary TB using Pearson correlation analysis. Results. Flow cytometry detected a significantly higher proportion of peripheral blood CD4+CD25+CD127low Tregs in the TB group than in the control group (9.14% ± 2.66% vs. 6.39% ± 1.73%; t = 4.067,

P
<
0.001

), and a higher proportion of peripheral blood CD4+CD25+CD127low Tregs among active pulmonary TB patients with a positive anti-M. tuberculosis antibody than in those with a negative antibody (Figure 2(a)); however, there were no gender, M. tuberculosis culture, tuberculin test, CT examination, or sputum smear test-specific proportions of CD4+CD25+CD127low Tregs among patients with active pulmonary TB. The PD-1 (6.13% ± 3.53% vs. 24.78% ± 7.73%,

P
<
0.05

) and PD-L1 levels (2.97% ± 2.00% vs. 9.23% ± 5.76%,

P
<
0.05

) were lower on peripheral blood CD4+CD25+CD127low Tregs among the TB group than in the control group. In addition, Pearson correlation analysis revealed a positive correlation between PD-1 and PD-L1 expression on peripheral blood CD4+CD25+CD127low Tregs among patients with active pulmonary TB (r = 0.435,

P
=
0.016

) and a negative correlation between the proportion of peripheral blood CD4+CD25+CD127low Tregs and PD-1 (r = ‒0.344,

P
=
0.024

) and PD-L1 expression among patients with active pulmonary TB (r = ‒0.310,

P
=
0.043

). Conclusion. The proportion of CD4+CD25+CD127low Tregs is higher in patients with active pulmonary TB than in healthy controls, and the negative costimulatory signal PD-1/PD-L1 expression is downregulated among active pulmonary TB patients. Our findings provide insights into the illustration of pathogenic mechanisms and immunotherapy of active pulmonary TB.
Linderalactone Suppresses Pancreatic Cancer Development In Vitro and In Vivo via Negatively Regulating PI3K/AKT Signaling Pathway
Authors: Xu Dongchao , Tian Mengyao , Chen Wangyang , Bian Ying , Xia Xiaofeng , Liu Qiang , Zheng Liyun , Zhang Xiaofeng , Shen Hongzhang
Published: August 2022

Linderalactone is one of the main extracts of Linderae Radix, which is widely used in traditional Chinese medicine. There have been few studies on the antitumor effect of linderalactone in the past. In this study, we explored the anti-pancreatic cancer activity of linderalactone in vitro and in vivo. The  results showed that linderalactone inhibited the proliferation of pancreatic cancer cells in a time- and dose-dependent manner. Cell migration and invasion were significantly inhibited by linderalactone. The cell cycle was arrested in the G2/M phase, and the expression levels of cell cycle-associated proteins changed significantly with linderalactone treatment. In addition, linderalactone induced cell apoptosis and altered the expression of apoptotic markers, such as caspase 3 and PARP1. Mechanistically, linderalactone suppressed the PI3K/AKT  signaling pathway by downregulating the phosphorylation of PI3K and AKT. The xenograft study results were consistent with the in vitro results, and there was no obvious chemical toxicity. Thus, our research demonstrated that linderalactone exhibits antitumor activity against pancreatic cancer and may be developed as a potential anti-pancreatic cancer agent in the future.
Application of Intelligent Recognition Technology in Recognition of Mechanical Material Structure
Authors: Zhang Xiaoyan , Wang Chensi , Wu Tao , Wang Yanfeng
Published: August 2022

In order to solve the related problems of mechanical material structure identification, the author proposes a method that integrates intelligent identification technology into mechanical material identification. Intelligent image recognition technology is based on image features, focusing on the main features of each image, and eliminates redundant input information, finds the key information needed, and completes the sorting of image information in stages to form a complete intuitive image. The experimental results show that the proposed method performs well in most cases, reaching 90.8% for coarse classification, 76.6% for medium classification, and 73.4% for fine classification. It is proved that artificial intelligence recognition technology is of great significance for the application of mechanical material structure recognition.
A Neural Network-Based Approach to Multi-Attribute Group Decision-Making with Heterogeneous Preference Information
Authors: Zhang Quan , Li Hongyu , Lu Xueting , Wu Chunliu
Published: August 2022

For the problem of multi-attribute group decision-making with heterogeneous preference information on attribute values and overall preference orderings on alternatives, this article proposes a neural network-based approach. In the approach, firstly, the heterogeneous preference information on attribute values and overall preference orderings on alternatives are normalized. Secondly, based on the normalization results, two optimization models are set up to determine attribute weights and expert weights, respectively. Thirdly, two neural networks are set up and trained to determine attribute weights and expert weights based on the optimization models. Then, the overall values of the alternatives are obtained as well as their rankings. Simulations on the proposed neural networks are conducted for illustrations.
Application of Digital Information Technology in Enterprise Innovation Management
Authors: Zhang Shengnan , Chi Xiaoni
Published: August 2022

Digital information technology is the key to realize the efficient management of enterprises. It is necessary to analyze the information technology and provide perfect operating conditions for enterprises in combination with the economic management of enterprises. This article studies enterprise management in the digital information environment, improves the effectiveness of enterprise management methods, and judges the management state of enterprises. At the same time, formula calculation is used to provide a test method for the application effect of digital information technology so that that information technology can be evaluated fairly. The experimental results show that enterprise management also involves inventory management. It is necessary to use information technology to identify products, record the process of products entering and leaving the warehouse in combination with code scanning technology, and optimize the product management process. In the process of enterprise management, the process management form should be adopted to improve the reliability of management methods and ensure that the enterprise has a normal management mode and perfection of enterprise operation state. It proves that digital information technology can promote the development of enterprises, improve the reliability of enterprise management, and reduce the impact of adverse factors on enterprises.
Optimization of Plane Image Color Enhancement Processing Based on Computer Vision Virtual Reality
Authors: Xue Renzheng , Liu Ming , Lian Zuozheng
Published: August 2022

In order to solve the problems of low brightness contrast of a color image, hiding a large amount of detail information, and deviation of color information in the process of image acquisition, an optimization method of plane image color enhancement processing based on computer vision virtual reality is proposed. In this method, the input RGB image is converted into the image represented by the HSI color model, and its adaptive brightness is adjusted to improve the overall brightness of the image. For the local detail enhancement of the color image, the three-dimensional Gaussian model perceived by retinal neurons is introduced into the illuminance image estimation of the MSR algorithm to enhance the image color. The results are as follows: from the perspective of objective parameter evaluation, the mean, standard deviation, information entropy, and average gradient of example images 1 and 2 are improved by about 70%; this algorithm not only enhances the brightness and contrast of the image but also maintains the detailed edge information of the image and the color characteristics of the object itself. The average enhancement rate is the highest among various algorithms, up to 95%. The algorithm proposed in this paper maintains the edge detail information of the image, optimizes the defects of the combination of traditional bilateral filtering and Retinex algorithm, and the color is also well restored, which makes the monitoring image easier to identify, more conducive to criminal investigation and solving cases, and lays a foundation for subsequent image processing.
A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX ± Bevacizumab versus FOLFOX ± Bevacizumab in Unresectable Untreated Metastatic Colorectal Cancer (VITALITY Study)
Authors: Wang Feng , He Ming-Ming , Xiao Jian , Zhang Yan-Qiao , Yuan Xiang-Lin , Fang Wei-Jia , Zhang Yan , Wang Wei , Hu Xiao-Hua , Ma Zhi-Gang , Yao Yi-Chen , Zhuang Zhi-Xiang , Zhou Fu-Xiang , Ying Jie-Er , Yuan Ying , Zou Qing-Feng , Guo Zeng-Qing , Wu Xiang-Yuan , Jin Ying , Mai Zong-Jiong , Wang Zhi-Qiang , Qiu Hong , Guo Ying , Shi Si-Mei , Chen Shuang-Zhen , Luo Hui-Yan , Zhang Dong-Sheng , Wang Feng-Hua , Li Yu-Hong , Xu Rui-Hua
Published: August 2022

Purpose:

To compare the efficacy and safety of high-dose vitamin C plus FOLFOX ± bevacizumab versus FOLFOX ± bevacizumab as first-line treatment in patients with metastatic colorectal cancer (mCRC).

Patients and Methods:

Between 2017 and 2019, histologically confirmed patients with mCRC (n = 442) with normal glucose-6-phosphate dehydrogenase status and no prior treatment for metastatic disease were randomized (1:1) into a control (FOLFOX ± bevacizumab) and an experimental [high-dose vitamin C (1.5 g/kg/d, intravenously for 3 hours from D1 to D3) plus FOLFOX ± bevacizumab] group. Randomization was based on the primary tumor location and bevacizumab prescription.

Results:

The progression-free survival (PFS) of the experimental group was not superior to the control group [median PFS, 8.6 vs. 8.3 months; HR, 0.86; 95% confidence interval (CI), 0.70–1.05; P = 0.1]. The objective response rate (ORR) and overall survival (OS) of the experimental and control groups were similar (ORR, 44.3% vs. 42.1%; P = 0.9; median OS, 20.7 vs. 19.7 months; P = 0.7). Grade 3 or higher treatment-related adverse events occurred in 33.5% and 30.3% of patients in the experimental and control groups, respectively. In prespecified subgroup analyses, patients with RAS mutation had significantly longer PFS (median PFS, 9.2 vs. 7.8 months; HR, 0.67; 95% CI, 0.50–0.91; P = 0.01) with vitamin C added to chemotherapy than with chemotherapy only.

Conclusions:

High-dose vitamin C plus chemotherapy failed to show superior PFS compared with chemotherapy in patients with mCRC as first-line treatment but may be beneficial in patients with mCRC harboring RAS mutation.
Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles
Authors: Xu Yitian , Zhang Licheng , Thaiparambil Jose , Mai Sunny , Perera Dimuthu Nuwan , Zhang Jilu , Pan Ping-Ying , Coarfa Cristian , Ramos Kenneth , Chen Shu-Hsia , El-Zein Randa
Published: August 2022

Tumors accumulated with infiltrated immune cells (hot tumors) have a higher response rate to immune checkpoint blockade, when compared with those with minimal T-cell infiltration (cold tumors). We report here that patients with lung cancer with different racial backgrounds harbored distinct immune cell profiles in the tumor microenvironment. Compared with African Americans (AA), Caucasian Americans (CA) exhibited increased immune cell infiltration and vasculature, and increased survival. Changes of survival and immune profile were most pronounced among active smokers and nonsmokers, compared with former smokers and total patients. Neighborhood analysis showed that immune cells accumulated around cancer cells in CAs but not AAs. Our findings reveal intrinsic biological differences between AA and CA patients with lung cancer, suggesting that treatment plans should be tailored for patients with different racial backgrounds.

Significance:

We report biological racial differences among patients with lung cancer where Caucasians present a hot tumor microenvironment compared with cold tumor in AAs. Treatment plans should be customized to maximize therapeutic outcomes.
New records for the poorly-known monotypic genera Exallostreptus and Guaporeptus, and a list of species from Mato Grosso state, Brazil (Diplopoda: Spirostreptida: Spirostreptidae)
Authors: Iniesta Luiz Felipe Moretti , Bouzan Rodrigo Salvador , Battirola Leandro Dênis , Brescovit Antonio Domingos
Published: August 2022

New records for the species Exallostreptus vanzolinii Hoffman, 1988 and Guaporeptus paradisius Hoffman, 1988, known only from the state of Rondônia, are made from the state of Mato Grosso, Brazil. Figures of gonopods, first and second leg-pair of males are provided. In addition, an updated list of 19 Spirostreptidae species from Mato Grosso is provided, with the species Plusioporus salvadorii, Trichogonostreptus (Oreastreptus) mattogrossensis, and Urostreptus tampiitauensis widely distributed in the state.
Updated catalog of the Chilean wedge-shaped beetles (Coleoptera: Ripiphoridae) with the first records of Macrosiagon flavipennis (LeConte) in Chile
Authors: Barahona-Segovia Rodrigo M. , Puiggros Andrés , Varela-Varela Ricardo A. , Valdés-Guzmán Vicente , Ramírez-Cuadros Andrés , Pañinao-Monsálvez Laura
Published: August 2022

The biology and ecology of wedge-shaped beetles (Coleoptera: Ripiphoridae) are scarcely known in the Neotropical realm. Chilean species of this beetle family are currently represented by two genera: Macrosiagon Hentz, 1830 and Ripiphorus Bosc, 1791, and three species, only known from their type localities. Here, we present an updated catalog of Chilean Ripiphoridae, along with the new distributional and biology records. Also, Macrosiagon flavipennis LeConte, 1866 (Ripiphorinae: Macrosiagonini) has been reported for the first time in Chile. We discuss the reasons for the presence of M. flavipennis in urban areas, the state of knowledge of the endemic species presents in Chile in relation to their distribution and the opportunity to use opportunistic records to better understand their natural history.
New species of Cerambycinae (Coleoptera, Cerambycidae) from Guatemala
Authors: Pérez-Flores Oscar , Santos-Silva Antonio
Published: August 2022

Three new species from Guatemala are described and illustrated: Ectenessa canoi sp. nov. (Ectenessini), from Petén; Oxycoleus schusteri sp. nov. (Oxycoleini), from Izabal; and Odontocera nigroaurantia sp. nov. (Rhinotragini), from Petén. Distinguishing characters from closely related species are provided.
Um recorte da relação entre poesia e identidade na literatura antilhana: Évelyne Trouillot e o Haiti.
Authors: Grace Danielle
Published: August 2022

Este artigo pretende investigar a questão da identidade tal como ela se manifesta na poesia antilhana contemporânea. Ao privilegiar alguns episódios da história literária das Antilhas e a poesia de Evelyne Trouillot (2014), em Par la fissure de mes mots, procura-se refletir sobre a construção das identidades na cena poética, interrogando-se sobre sua relação com a história colonial e a forja de uma consciência coletiva. Para tanto, recorre-se a um referencial teórico que permite pensar as literaturas em seus contextos atuais e em relação aos traumas da escravidão (FIGUEIREDO, 1998; 2006). Além disso, busca-se entender o papel da poesia na busca de uma fundação identitária (GLISSANT, 1996) e o político que se evidencia nos percursos poéticos privilegiados por escritores e escritoras das Antilhas de língua francesa (JEAN, 2018).
"Poética natural, poética forçada", de Édouard Glissant
Authors: Santos Thadeu C. , Amaral Henrique Provinzano
Published: August 2022

Neste artigo, Édouard Glissant resume suas principais proposições para as poéticas da Relação, configuradas em torno do conflito entre o crioulo e o francês tal qual se deu (e se dá) na Martinica. A Relação, grafada por Glissant com R maiúsculo, se opõe aqui ao Ser. A subjetividade de quem diz, traçada em jogo na trama interpoética caribenha, decanta de uma crítica ao ser unificado e circunscrito, ao qual se oporia o ser-da-Relação. Este, uma vez incompleto, tenderia a se completar, mas sem nunca terminar de fazê-lo, na vivência com os Outros. É não só incompleto, mas móvel e mutante em sua incompletude, conforme as relações se transformam e se engajam em diferentes relações com diferentes Outros. Glissant nos provoca a perceber essas dinâmicas de identificação e opacidade na consulta dos resultados dessas linguagens, produtos da experiência entre as poéticas livre e forçadas. Essa compreensão não é apenas pertinente para analisarmos as cenas contemporâneas de arte e seus processos de exclusão, mas sim, e principalmente, pelo valor de transgressão da cultura popular frente os esquemas de classificação, do cânone e da história da arte e da literatura. Ainda mais, favorece grandemente os estudos das poéticas da voz, que encontram na via da Relação uma autonomia poética e discursiva dentro dos sistemas literários.
"Retorno ao país letal"/"Retour au pays létal", de Ketty Steward: tradução em português e texto em francês
Authors: Ribeiro Ana Cláudia Romano , Souza Claire Silva de
Published: August 2022

Se a ficção científica de autoria feminina de língua inglesa conta com nomes que se tornaram referências incontornáveis e já foram traduzidos no Brasil – Mary Shelley, Octavia Butler, Ursula Le Guin, para citar apenas três – as obras de ficção científica escritas por autoras de língua francesa não parecem ser numerosas, nem conhecidas. Dentre as autoras francófonas, uma referência incontornável é Ketty Steward, de origem martiniquense, mas atualmente radicada em Paris. Dela, apresentamos aqui em versão bilíngue Retorno ao país letal (Retour au pays létal), um “conto de auto-ficção científica”, nas palavras da própria autora, em tradução feita por Claire Silva de Souza, aluna do curso de licenciatura em Letras, habilitação Português-Francês, da Universidade Federal de São Paulo, e sua orientadora, Ana Cláudia Romano Ribeiro. Retour au pays létal foi publicado na coletânea Faites demi-tour dès que possible pela editora independente francesa La Volte em 2014.
Como se fosse um vaso: Luto, política e feminismos na escrita de Carla Rodrigues
Authors: Silveira Léa
Published: August 2022

Resenha de: Rodrigues, C. (2021). O luto entre clínica e política: Judith Butler para além do gênero. Belo Horizonte: Autêntica.
A ontologia finkiana do jogo: introdução ao ensaio “Oásis da felicidade”
Authors: Giubilato Giovanni
Published: August 2022

Apresentação de "Oásis da felicidade: Pensamentos para uma ontologia do jogo (1957)"
O paradoxo da emancipação: populismo, democracia e a alma da esquerda
Authors: Azmanova Albena , Sousa Filho José Ivan Rodrigues de
Published: August 2022

Tradução de: Azmanova, A. (2019). The paradox of emancipation: populism, democracy and the soul of the Left. Philosophy and Social Criticism, 45 (9-10), 1186-1207. DOI: https://doi.org/10.1177/0191453719872291. Traduzido por Ivan Rodrigues
 
Que conexão há entre o vagalhão populista e a queda do apoio eleitoral às tradicionais posições ideológicas à esquerda? Como podemos explicar o declínio da esquerda sob condições que deveriam estar catapultando-a para o poder? Argumento que a esquerda, na sua reação tanto à hegemonia neoliberal como à ascensão do populismo, está afetada pelo que Nietzsche chamou de “preconceito democrático” – o reflexo de ler a história como o advento e a crise da democracia. Em decorrência disso, a esquerda tenta agora recuperar a democracia por meio da ressurreição do conjunto de políticas de crescimento-e-redistribuição característico da “era dourada” da social-democracia nas três décadas após a Segunda Guerra Mundial. Esse gesto nostálgico, todavia, está levando a esquerda a outro impasse, àquilo que chamo de “paradoxo da emancipação” – ao lutar por igualdade e inclusão como condições essenciais da cidadania democrática, a esquerda está validando a ordem social no interior da qual ela está buscando igualdade e inclusão, a saber, a ordem social moldada pela produção concorrencial de lucro, a qual é a causa básica pela qual as nossas sociedades se encontram encalacradas. Concluo a análise propondo a construção de uma contra-hegemonia contra o capitalismo neoliberal mediante o alargamento do enfoque da esquerda, de modo a que a esquerda não se restrinja às suas preocupações tradicionais com a desigualdade e a exclusão, mas dê conta também da injustiça da crescente insegurança social e econômica – um dano cujo alcance vai além dos trabalhadores pobres. Uma agenda reformulada de justiça social que tenha como eixo questões de insegurança econômica que atravessam a “clivagem de classes” possibilitaria à esquerda mobilizar uma ampla coalizão de forças sociais para a transformação radical e duradoura em direção à democracia socialista.
Holding the Aggressor Accountable
Authors: Atadjanov Rustam
Published: August 2022

The issue of the necessity to bring those responsible for the commission of crimes under international law during the ongoing international armed conflict in Ukraine, i.e., the aggressive war of the Russian Federation against sovereign Ukraine, does not raise any principal questions or doubts on the side of the international community. It is the matter of an appropriate forum, or fora to do so that needs to be properly addressed. This piece looks at possible judicial venues for holding the main ringleader of the aggressive war, namely, the President of the Russian Federation, and his closest high-ranking officials personally accountable for core crimes as a matter of individual criminal responsibility. Prospects for three judicial mechanisms, either already existing or potential, are reviewed and brief reflections are offered as to the realistic scenarios for each of those mechanisms given the status quo and ongoing developments.
Mission: Impossible? Reforming the UN Charter to Limit the Veto
Authors: Paige Tamsin Phillipa
Published: August 2022

The Russian invasion of Ukraine has once again brought the question of the limits of the veto by the P5 in the UN Security Council into the spotlight. This short piece examines the possibility of the veto power of the P5 being restricted and the possibility of reform of the UN Charter to restrict or abolish the veto. After concluding that the drafting of the Charter makes these approaches unworkable it then considers the possibility of the UN being reformed under a new Charter that has a more equitable Security Council – concluding that such an approach is functionally impossible.
Corruption in International Law: Illusions of a Grotian Moment
Authors: Ross Simona , Somos Mark
Published: August 2022

Has there already been a Grotian Moment for corruption? If not, what would it take for new legal rules and doctrines on corruption to crystallise? This article seeks to answer these two questions by reviewing the relevant history of international legal scholarship, the current public international law framework for anticorruption, and recent developments in international legal practice. We conclude that a Grotian Moment may have been reached for a narrow concept of corruption, focused on petty corruption and bribery, with the proliferation of international anticorruption law following the Cold War. However, a Grotian Moment for a broadened understanding of corruption, based on other forms such as institutional, political, and grand corruption, ought to emerge to comprehensively address all forms of corruption. Given the range of challenges, including resistance from political elites and the indeterminacy of criminal liability, a Grotian Moment for a broadened concept of corruption remains improbable.
Statehood: A Grotian Moment 2
Authors: Sterio Milena
Published: August 2022

Grotian Moments are instances of accelerated formation of customary law, sparked by significant world events, such as wars, terrorism attacks, developments in technology, or natural catastrophes. This article will apply the Grotian Moment theory to the legal criteria of statehood, in an attempt to assess whether an evolution in specific elements of statehood has resulted in such paradigm-shifting Grotian Moments. In particular, this article will argue that the evolving political nature of our world order has contributed toward the need to re-conceptualize the legal theory of statehood. This article will thus posit that this constitutes a so-called Grotian Moment 2: a period of time when significant contestation of prevailing international legal norms and institutions occurs, and when novel thinking, norms and institutions attempt to replace elements of the old but may not succeed in doing so. This article posits that developments in the legal theory of statehood may be best described as Grotian Moment 2 although various historical and political developments have reshaped our contemporaneous conception of statehood, it may be argued that international law itself has neither contributed to the evolution of a new legal theory of statehood nor changed its own norms.
Alkali-Microwave Co-Pretreatment to Enhance the Solid-State Anaerobic Digestion Performance of Vinegar Residue
Authors: Jin Yan , Feng Jia-Yu , Song Chao , Wang Li-Gong , Chen Chang , Liu Guang-Qing
Published: August 2022

Large amounts of vinegar residue generated in the vinegar brewing process have been a severe threat to the environment. In this study, solid-state anaerobic digestion has been applied for sensible utilization of vinegar residue. Besides, alkali pretreatments, microwave pretreatment,
and their combinations were introduced to enhance the degradation of vinegar residue in solid-state anaerobic digestion. Results showed alkaline hydrogen peroxide and microwave co-pretreatment performed better in regard to the cumulative methane yield, showing a remarkable increase of 34.6%
(p<0.01) compared with untreated. The kinetic behavior of solid-state anaerobic digestion was successfully simulated using the modified Gompertz model. Scanning electron microscopy and X-ray diffraction analysis measurements indicated great destruction and transformation of the lignocellulosic
structure of vinegar residue after the co-pretreatment. This research not only afforded a hopeful pretreatment approach for the efficient methane production of vinegar residue but also evaluated the feasibility of methane production after pretreatment under solid-state anaerobic digestion
condition, which will also lay a good foundation for the utilization of other biowastes in the future.
Identification of Drought Tolerant Rice Genotypes Based on Morpho-Physiological and Yield Traits Under Normal and Drought Stress Conditions
Authors: Abdelaty Mohamed S. , El-Abd Abdelmoaty B. , Ibrahim Magdy H. , Youssif Anwar , Batool Maria , Sami Rokayya , Ashour Amal Adnan , Shafie Alaa , Hassan Hamada M.
Published: August 2022

Water shortage is a serious climatic factor that drastically limits rice productivity. Thereupon, the development of better adapting rice genotypes under water deficit stress is imperious to maintain rice yield to ensure food security worldwide. The current study focused on genetic
variability of morpho-physiological traits of rice to discover relationships between morpho-physiological and yield contributing traits under drought stress conditions in 24 rice genotypes during 2019 and 2020 seasons. Results showed highly significant mean squares of combined analysis for
treatments and environment of all studied traits under normal and drought stress conditions. Results reported that the earliest rice cultivars were Giza177 and Giza179; however, the highest yield and its components traits were detected for Giza179, followed by Giza178, Sakha101 and Sakha108
under normal and water deficit conditions; moreover, generally, PCV was higher than GCV for all studied traits. High heritability coupled with high genetic advance was noted for plant height and relative water content under normal and drought conditions, suggesting a preponderance of additive
gene action in expressing these traits that could be improved by selection in early segregating generations. While, high heritability coupled with moderate genetic advance was noticed for duration, grain yield/plant and harvest index under both conditions. Giza179 and Giza178 showed the best
values for drought tolerance and were produced from same genetic background. Moreover, grain yield/plant showed a highly significantly positive correlated with panicle length, number of panicles/plant, panicle weight and 100-grain weight under normal and water deficit conditions; moreover,
these traits were the main components of grain yield, so any selection based on these traits may lead to enhancement in grain yield. As a result, Giza178 and Giza179 varieties can be introduced as donors in breeding programs to tolerate water shortages to improve morphological and yield characteristics.
Characterization and the Genetic Diversity in Pummelo Using Fruit Traits and SSR Markers
Authors: Haque Syed Rafiul , Hossain Md Mokter , Rahim Md Abdur , Alam Md Sarowar , Elhakem Abeer , Alqurashi Mohammed , Althaqafi Mohammed M. , Aloufi Salman , Sami Rokayya
Published: August 2022

Pummelo is one of the basic citrus species of horticultural importance for human health and nutrition security. It has wide genetic diversity due to its breeding behavior during the domestication process. The present research was performed to study the fruits traits and characterization
of the studied 21 pummelo genotypes with morphological, fruit quality parameters, and SSR markers. Principal component analysis (PCA) was done to get PC individual plot and clustering the genotypes in five main clusters based on 17 morphological traits. The highest number (08) of genotypes
was grouped in cluster V and the lowest (01) in cluster III. Genotypes resided with the highest genetic distance in the individual biplots are promising for suitable parents. Again, molecular characterization or cluster analysis was performed with 5 SSR markers. The PIC values ranged from
a low of 0.66 (CAC23) to a high of 0.8787 (TAA41) and averaged 0.78. TAA41 presented the second largest (47 bp) difference among allele size range and the largest (11) number of alleles with the highest gene diversity value (0.88). The average genetic distance among the 21 pummelo genotypes
were 0.8362. The NJ cluster analysis led to the grouping of the pummelo genotypes in three major clusters (I, II, and III). The genotypes resided in the similar cluster should be avoided for pummelo improvement. The findings of this research would be useful to select desirable parents for
future pummelo breeding program.