bluuebunny/crossref_metadata_2025 huggingface dataset:
mRNA expression of ferroptosis-related proteins in squamous cell carcinoma of tongue
Authors: Thavarajah Rooban
Published: May 2020

Objective:

Glossal Squamous Cell Carcinoma (GSCC) has a distinct molecular profile including alterations in programed regulated cell death (RCD). Ferroptosis is a newly reported form of RCD mediated by ferric ions and mediated by several proteins. Till date, the possibility of this phenomenon in GSCC has not been explored.

Materials and Methods:

The proteins associated with ferroptosis were collated. The mRNA of corresponding proteins expression from GSCC lesional tissues and control tissues from the same patient from the human cancer genome project was obtained as raw values and subjected to differential expression (DE) analysis using DESeq2 statistics. The Benjamini and Hochberg (false discovery rate) approach was used to adjust P-value and P ≤ 0.05 was set at statistical significance. Log fold change was set at 0.6. The significant genes were subjected to network analysis for protein-protein interaction and this network was analyzed for pathway enrichment analysis and presented.

Results:

There were 12 cases that had GSCC and controls (n = 12). There were 40 genes directly involved with ferroptosis and another 50 genes associated with the ferroptosis. Of this, 28 genes had DE, of which 16 genes were directly involved in the ferroptosis pathway and 12 genes associated with it. These genes, in enrichment analysis, indicated that the other pathways involved several other cancers and cancer signaling. Certain pro-ferroptotic genes and anti-ferroptotic genes had DE. Increase of PTGS2 and ACSL4 mRNA expression in GSCC tissue as compared to control was a significant finding. There is an increase of mRNA of genes that increase the ferric ions intracellularly. These findings would help to draw better and effective treatment strategies that can help to target neoplastic cells in GSCC.

Conclusion:

In GSCC, ferroptosis is a possibility and the differential expression of certain pro-ferroptotic genes could he harnessed to draw effective and safer treatment strategies.
Pelatihan English for Educator Bagi Guru Tingkat SMK di Kota Semarang
Authors: Bowo Tri Arie , Dewi Maya Kurnia , Budiati Budiati
Published: May 2020

Program Pengabdian Kepada Masyarakat dengan judul pelatihan English for Educator Bagi Guru Tingkat SMK di Kota Semarang merupakan pelatihan Bahasa Inggris yang dikhususkan untuk pengajaran di kelas. Mitra dalam pengabdian masyarakat ini adalah institusi pendidikan vokasi yakni Sekolah Menengah Kejuruan Persatuan Guru Republik Indonesia 01 yang terletak di kota Semarang. Permasalahan yang dialami mitra yakni kurangnya kemampuan guru SMK PGRI 01 Semarang untuk mengajar dengan menggunakan Bahasa Inggris. Hal tersebut karena kurangnya pelatihan bahasa Inggris yang dikhususkan untuk guru-guru di sekolah tersebut. Secara spesifik, kurangnya kemampuan guru dalam bahasa Inggris yakni dalam keterampilan speaking (berbicara). Solusi permasalahan mitra yang ditawarkan dalam pengabdian masyarakat ini adalah pelatihan English for Educator yakni pelatihan untuk guru-guru/pengajar yang merupakan gabungan dari metode classroom language dan bahasa Inggris dasar. Pada pelaksanaan pelatihan ditemukan bahwa penguasaan vocabulary peserta kurang memadai. Oleh karena itu, efektivitas pelatihan berbasis speaking kurang terlihat efektivitasnya. Pelatihan berbasis vocabulary perlu dilakukan untuk meningkatkan kemampuan guru dalam ketrampilan speaking.
Spatial Metabolomics of the Human Kidney Using MALDI Trapped Ion Mobility Imaging Mass Spectrometry
Authors: Neumann Elizabeth , Migas Lukasz , Allen Jamie L. , Caprioli Richard , Van de Plas Raf , Spraggins Jeffrey
Published: May 2020

Small metabolites are essential for normal and diseased biological function but are difficult to study because of their inherent structural complexity. MALDI imaging mass spectrometry (IMS) of small metabolites is particularly challenging as MALDI matrix clusters are often isobaric with metabolite ions, requiring high resolving power instrumentation or derivatization to circumvent this issue. An alternative to this is to perform ion mobility separation before ion detection, enabling the visualization of metabolites without the interference of matrix ions. Here, we use MALDI timsTOF IMS to image small metabolites at high spatial resolution within the human kidney. Through this, we have found metabolites, such as arginic acid, acetylcarnitine, and choline that localize to the cortex, medulla, and renal pelvis, respectively. We have also demonstrated that trapped ion mobility spectrometry (TIMS) can resolve matrix peaks from metabolite signal and separate both isobaric and isomeric metabolites with different localizations within the kidney. The added ion mobility data dimension dramatically increased the peak capacity for molecular imaging experiments. Future work will involve further exploring the small metabolite profiles of human kidneys as a function of age, gender, and ethnicity.
van der Waals Potential: An Important Complement to Molecular Electrostatic Potential in Studying Intermolecular Interactions
Authors: Lu Tian , Chen Qinxue
Published: May 2020

Electrostatic and van der Waals (vdW) interactions are two major components of intermolecular weak interactions. Electrostatic potential has been a very popular function in revealing electrostatic interaction between the system under study and other species, while the role of vdW potential is less recognized and has long been ignored. In this paper, we explicitly present definition of vdW potential, describe its practical implementation, and demonstrate its important value by visual analysis and comparing it with spatial distribution function obtained via molecular dynamics simulation. We hope this work can arouse researchers' attention to van der Waals potential and promote its application in practical studies of weak interaction. Calculation, visualization and quantitative analysis of the vdW potential have been supported by our freely available code Multiwfn (http://sobereva.com/multiwfn).
An Online Repository of Solvation Thermodynamic and Structural Maps of SARS-CoV-2 Targets
Authors: Olson Brian , Cruz Anthony , Chen Lieyang , Ghattas Mossa , Ji Yeonji , Huang Kunhui , McKay Daniel J. , Kurtzman Tom
Published: May 2020

SARS-CoV-2 recently jumped species and rapidly spread via human-to-human transmission to cause a global outbreak of COVID-19. The lack of effective vaccine combined with the severity of the disease necessitates attempts to develop small molecule drugs to combat the virus. COVID19_GIST_HSA is a freely available online repository to provide solvation thermodynamic maps of COVID-19-related protein small molecule drug targets. Grid Inhomogeneous Solvation Theory maps were generated using AmberTools cpptraj-GIST and Hydration Site Analysis maps were created using SSTmap code. The resultant data can be applied to drug design efforts: scoring solvent displacement for docking, rational lead modification, prioritization of ligand- and protein- based pharmacophore elements, and creation of water-based pharmacophores. Herein, we demonstrate the use of the solvation thermodynamic mapping data. It is hoped that this freely provided data will aid in small molecule drug discovery efforts to defeat SARS-CoV-2.
Potential Drugs Targeting Nsp16 Protein May Corroborates a Promising Approach to Combat SARSCoV-2 Virus
Authors: Shankar Uma , Jain Neha , Majee Prativa , Mishra Subodh Kumar , Rathi Brijesh , Kumar Amit
Published: May 2020

The recent ongoing pandemic caused by SARS-CoV-2 continues to impose devastating impacts and is accountable for the loss of more than 250,000 human lives within a short span of four months. This urges immediate therapeutic measures to control the impact of this disease. One of the most conserved and potentially druggable sites is the Nsp16 active site that performs the 2’-O-methyltransferase activity and puts a 5’ cap on the viral RNA molecules. This allows them to mimic endogenous transcripts for the efficient translation of viral proteins and evasion of the immune response. Herein, we screened three libraries of compounds (>5500) with chemical diversity to identify hits against Nsp16 active site of SARS-CoV-2. From each library a top hit was identified, namely Velpatasvir from the FDA compounds; JFD00244 from the LOPAC library and compound 6 from the SAM based analog library. Interestingly, all three hits showed higher affinity than the positive controls. Velpatasvir is a known anti-viral drug used against Hepatitis C virus, and JFD00244 is a SIRT2 inhibitor. 100ns molecular simulation studies showed all three molecules to have stable and energetically favourable interactions with the active site of Nsp16. In summary, this investigation identified three potential drug candidates that are predicted to be potent Nsp16 inhibitors and could be pursued further in cell-based studies.
Stereoretentive Ring-Opening Metathesis Polymerization to Access All-cis Poly(p-phenylene vinylene)s with Living Characteristics
Authors: Hsu Ting-Wei , Kim Cheoljae , Michaudel Quentin
Published: May 2020

Poly(p-phenylene vinylene)s (PPVs), a staple of the conductive polymer family, consist of alternating alkene and phenyl groups in conjugation. The physical properties of this organic material are intimately linked to the cis/trans configuration of the alkene groups. While many synthetic methods afford PPVs with alltrans stereochemistry, very few deliver the all-cis congeners. We report herein the first synthesis of all-cis PPVs with living characteristics via stereoretentive ring-opening metathesis polymerization (ROMP). Exquisite catalyst control allows for the preparation of homopolymers or diblock copolymers with perfect stereoselectivity, narrow dispersities, and predictable molecular weights. All-cis PPVs can then serve as light-responsive polymers through clean photoisomerization of the stilbenoid units.
Iterative Supervised Principal Component Analysis-Driven Ligand Design for Regioselective Ti-Catalyzed Pyrrole Synthesis
Authors: See Xin Yi , Reiner Benjamin , Wen Xuelan , Wheeler T. Alexander , Klein Channing , Goodpaster Jason , Tonks Ian
Published: May 2020

Herein, we describe the use of iterative supervised principal component analysis (ISPCA) in de novo catalyst design. The regioselective synthesis of 2,5-dimethyl-1,3,4-triphenyl-1H- pyrrole (C) via Ti- catalyzed formal [2+2+1] cycloaddition of phenyl propyne and azobenzene was targeted as a proof of principle. The initial reaction conditions led to an unselective mixture of all possible pyrrole regioisomers. ISPCA was conducted on a training set of catalysts, and their performance was regressed against the scores from the top three principal components. Component loadings from this PCA space along with k-means clustering were used to inform the design of new test catalysts. The selectivity of a prospective test set was predicted in silico using the ISPCA model, and only optimal candidates were synthesized and tested experimentally. This data-driven predictive-modeling workflow was iterated, and after only three generations the catalytic selectivity was improved from 0.5 (statistical mixture of products) to over 11 (> 90% C) by incorporating 2,6-dimethyl- 4-(pyrrolidin-1-yl)pyridine as a ligand. The successful development of a highly selective catalyst without resorting to long, stochastic screening processes demonstrates the inherent power of ISPCA in de novo catalyst design and should motivate the general use of ISPCA in reaction development.
To the projects and challenges of domestic hydrophysical study of the global ocean’s polar regions
Authors: Neiman V. G.
Published: May 2020

One of the climatically significant, but the poor studied hydrophysical factor in the polar
regions of the world ocean is the subsurface layer of relatively warm seawater of subtropical origin. In the Arctic Ocean, this layer is associated with the waters of the Gulfstream, the highlatitude continuation of which in the form of a spur of the North Atlantic current penetrates into the Arctic basin, where it sinks to the depth of its density and spreads throughout its vast space in the layer of 100–900 m. The existence of a subsurface layer with an anomalous inversion vertical profile of water temperature also occurs in the Southern ocean. The article discusses the problem of monitoring the dynamics of this layer and obtaining data from a field experiment on its interaction with the atmosphere in the context of the to-day climate change of the Arctic and Antarctic. There is a reason to hope that the planned development of modern Russian scientific research in the polar regions of the world ocean will help to solve this important climatic problem. The paper presents some key results of this kind of domestic
oceanological studies of the mid-twentieth century, which made a significant contribution to the theory and experiment related to the dynamics of the Southern ocean.
Job Finding Rate and Female Labor Supply- A Heterogeneity Perspective
Authors: Nargis .  , Nooreen Mujahid
Published: May 2020

Background: In contemporary labor economics, the concept of job finding rate is central as it defines the job search and measures the employment potential of the labor market. Considering this fact, economists primarily count on measuring the flows of labor between the labor market states. The study is an endeavour to design a conceptual framework to determine female labor supply considering these labor market flows and job finding rate in Pakistan.

Methodology: The study evaluates various search models and provides a comprehensive review of literature taking into consideration job finding rate and female labor supply. Electronic databases including Google Scholar & Medline were used. Articles, books, and conference proceedings were cited using keywords like Job Finding rate, female labor and labor market, etc.      

Result: The study has introduced the perspective of heterogeneity to incorporate the composition effect and dispersion effect of the labor market. The framework of the study provides a hint for policy makers to consider the relevant flows for improvement in female employment in Pakistan.

Conclusion: The main conclusion stresses on including the inactive group to link up the job finding rate with female labor supply. Not doing so would bias the imputed importance of factors shaping aggregate participation and unemployment rates.
Pengaruh Pemupukan Nitrogen Terhadap Tinggi dan Percabangan Tanaman Teh (Camelia Sinensis (L.) O. Kuntze) untuk Pembentukan Bidang Petik
Authors: Pamungkas Miftah Anugrah , Supijatno .
Published: May 2020

Penelitian ini bertujuan untuk mengetahui pengaruh berbagai dosis pupuk nitrogen terhadap tinggi dan percabangan tanaman teh (Camelia sinensis (L.) O. Kuntze). Penelitian dilaksanakan pada Februari hingga Juni 2012 di Kebun Percobaan Cikabayan Atas IPB, Darmaga, Bogor. Penelitian ini merupakan percobaan satu faktor dengan menggunakan Rancangan Acak Kelompok (RAK) dengan 4 ulangan. Perlakuan terdiri dari (P0 :  60 kg N ha-1; P1 :  120 kg N ha-1; P2 :  180 kg N ha-1; P3 :  240 kg N ha-1). Hasil dari penelitian menunjukkan bahwa pemupukan nitrogen memberikan pengaruh nyata terhadap tinggi tanaman pada minggu kedua pengamatan, jumlah daun pada minggu kedelapan hingga minggu keenam belas pengamatan, diameter batang pada minggu pertama hingga minggu ketiga pengamatan serta pada pengamatan cabang sekunder. Secara  keseluruhan perlakuan 180  kg N ha-1  merupakan  perlakuan terbaik tetapi tidak berbeda  dengan perlakuan  120 kg N ha-1. Pemupukan nitrogen tidak berpengaruh nyata terhadap jumlah cabang primer, kehijauan daun serta persentase tinggi tanaman lebih 70 cm.
Pertumbuhan Beberapa Genotipe Jarak Pagar (Jatropha Curcas L.) di Tanah Masam
Authors: Retnowati Indah , Surahman Memen
Published: May 2020

Indonesia memiliki banyak  tanah masam, tetapi penggunaan masih sangat sedikit karena kandungan nutrisi tanah masam rendah. Sementara itu, jarak pagar merupakan tanaman yang dapat tumbuh di berbagai jenis tanah (termasuk lahan marjinal) dan penggunaannya sebagai bahan baku biodiesel. Oleh karena itu, perlunya penelitian mengenai pertumbuhan jarak pagar pada tanah masam sebagai upaya untuk mengembangkan jarak pagar dan penggunaannya di Indonesia.Untuk memulai upaya, penelitian tentang berbagai genotipe jarak pagar di tanah masam telah dilakukan. Tujuan dari penelitian ini yaitu mempelajari genotipe jarak pagar  yang berpotensi untuk tanah masam. Penelitian ini dilakukan di UPTD Pengembangan Teknologi Lahan Kering Singabraja, Kecamatan Tenjo, Bogor, Jawa Barat, dari November 2010-Agustus 201. Penelitian ini menggunakan Rancangan Kelompok Lengkap Teracak (RKLT) dengan satu faktor yaitu genotipe. Hasil penelitian menunjukkan berbagai perbedaan pada pertumbuhan diantara genotipe-genotipe jarak pagar. Secara umum, ada lima genotipe jarak pagar yang terbaik di tanah masam (pH 5.0) yaitu Medan I-5-1, Dompu, IP-2P-3-4-1, Sulawesi, dan Bima M.
Inventarisasi Jenis-Jenis Lumut (Bryophyta) di Daerah Aliran Sungai Kabura-Burana Kecamatan Batauga Kabupaten Buton Selatan
Authors: Endang Titi , Jumiati Jumiati , Pramesthi I. A Dyah
Published: May 2020

Abstrak: Lumut (Bryophyta) merupakan kelompok tumbuhan tingkat rendah yang tumbuh meluas di daratan. Secara ekologi lumut berperan penting dalam ekosistem, seperti menjaga keseimbangan air, siklus hara, menjadi habitat penting bagi organisme lain, dapat dijadikan sebagai bioindikator karena tumbuhan ini lebih sensitif terhadap perubahan lingkungan dan merupakan tumbuhan perintis. Pentingnya peran lumut dan belum adanya data mengenai jenis-jenis lumut di Daerah Aliran Sungai Kabura-burana maka sangat perlu dilakukan penelitian ini ÃÂ untuk mengetahui jenis-jenis lumut yang tumbuh di Daerah Aliran Sungai Kabura-burana. Penelitian ini merupakan penelitian kualitatif dengan menggunakan metode eksplorasi. Hasil penelitian diperoleh 15 spesies lumut yang terdiri atas 11 spesies lumut daun dan 4 spesies lumut hati. Delapan jenis lumut teridentifikasi sampai tingkat spesies, lima jenis teridentifikasi hingga tingkat genus dan dua lainnya teridentifikasi hingga tingkat familia. Kata Kunci: Bryophyta;ÃÂ ÃÂ  Inventarisasi; Lumut; SpesiesAbstract: Moss (bryophyta) is a group of low-level plants thatgrow widely on land. Ecologically the moss plays an important role in the ecosystem, such as maintaining water balance, nutrient cycles, being an important habitat for other organisms, can be used as a bioindicator because these plants are more sensitive ti environmental changes and are pioneering plants. The important of the role of mosses and the absenceof data on the types of mosses in the Kabura-burana River Basin, it is necessary to conduct this research to determine the types of mosses that grow in the Kabura-burana River Basi. This research is a qualitative research using exploratory methods. The result obtained by 15 species of mosses consisting of 11 species of musci and 4 species of liverworts. Eight species of mosses are identified up to the species level, five types of moss are identified up to genus level and other two are identified up to the family level.Keywords: Bryophyta;Inventory; Moss; SpeciesÃÂ ÃÂ
Breves costuras a partir de Rosana Paulino e as vozes do Sul
Authors: Martins Catia Paranhos
Published: May 2020

Neste ensaio apresento um breve diálogo entre algumas obras da artista Rosana Paulino e as vozes do Sul. Penso a artista como “arquivo vivo”, inspirada pela interpretação feita por Maria A. Antonacci, cuja poética utiliza-se, em especial, da “memória ancorada em corpos negros”. O que não se pode ver e dizer? Quem ainda não é vista e ouvida? Quais vidas estão nos bastidores, invisíveis e não podem compor o ato? O que dizem estas pessoas - mulheres negras - através de silenciamentos e cegueiras? Interesso-me por aceitar a provocação das obras mais do que construir possíveis respostas. Dentre tantas aprendizagens e afetações, destaco o corpo como território tanto pessoal quanto político, estratégia utilizada pela artista para (re)afirmar que mulheres, corpos feminizados e/ou racializados são sujeitos desejantes e que gestam mundos outros. É o corpo e sua memória como suportes de criação de existências e experimentações que questionam o projeto colonial-capitalista.
Комбінована методика оцінювання компетентності експертів при виборі сценарію організації інформаційно-психологічного впливу
Authors: Пєвцов Г.В. , Усачова О.А. , Пацек П. , Романюк А.О.
Published: May 2020

Запропонована методика оцінювання компетентності експертів при виборі раціонального сценарію прийняття рішення на організацію інформаційно-психологічного впливу (ІПВ). Подана в загальному вигляді модель вибору сценарію прийняття рішення на організацію ІПВ, яка включає в себе елементи різних методів, в тому числі методу аналізу ієрархій. Оптимізація групового рішення здійснюється на основі обґрунтованої процедури узгодження. Особливістю моделі є те, що вона враховує показник пріоритету експерта в групі, який характеризує його компетентність (важливість) в галузі інформаційно-психологічної боротьби. Окрім того, для оцінювання компетентності експертів, що здійснюють вибір сценарію, враховані нестандартні характеристики, такі як творче мислення, багатоваріантність рішень, гнучкість, здібність до абстрактного мислення, креативність. Введення показника компетентності експерта дозволяє суттєво спростити методику обробки даних групової експертизи та зробити результати її застосування більш достовірними. Також запропоновано алгоритм розрахунку мінімальної чисельності експертів для проведення експертизи об'єктів впливу.
Науково-методологічні аспекти управління ризиками у системі державного оборонного замовлення
Authors: Турінський О.В. , Демідов Б.О. , Гриб Д.А. , Хмелевська О.О.
Published: May 2020

У статті розглядаються актуальні аспекти, що пов'язані з процедурами формування і реалізації державних оборонних замовлень в умовах прояву різних факторів ризику. Основна увага зосереджена на науково-методичному підході до оцінювання рівня очікуваних ризиків і управління цими ризиками. Відмічається, що використання при формуванні і реалізації державного оборонного замовлення відповідних адекватних методів, моделей і методик буде сприяти зменшенню рівня ризику і підвищенню результативності виконання завдань і заходів державного оборонного замовлення. Доведено, про доцільність врахування у вітчизняній практиці накопиченого позитивного досвіду провідних країн світу із зменшення ризиків невиконання наукових і інших перспективних (інноваційних) проектів створення зразків озброєння і військової техніки, які мають складати основу системи озброєння збройних сил держави. Під ризиком у статті розуміється міра нездатності досягнення мети програми у рамках запланованої вартості, термінів робіт і технічних вимог, що надає ризику складових імовірності недосяжності конкретної мети програми і наслідків недосяжності даної мети. За досвідом МО США виділяються аспекти прийняття ризику, ухилення від ризику, контролю ризику, передачі ризику і комбінації вищевказаних способів для реагування на подію ризику. Виділяється найбільш важливий метод оцінювання факторів ризику у системі державного оборонного замовлення, що зорієнтований на встановлення величини втрат економічного характеру. Приводиться актуальність проблеми управління ризиками у процесі виконання заходів державного оборонного замовлення і державних цільових програм розвитку озброєння і військової техніки в умовах збільшення невизначеності і все більшого розширення масштабів прояву факторів ризику. Виокремлена необхідність створення дієвого бережливого механізму господарювання оборонно-промислового комплексу держави в умовах прояву різних факторів ризику на усьому періоді життєвого циклу системи озброєння збройних сил.
A conceptual approach to defining a structure for spatially distributed network-centric system for controlling the tier of air defense missile cover
Authors: Шамко В.Є.
Published: May 2020

In the context of the Joint Forces operation in eastern Ukraine and the new challenges of the hybrid war on the part of the Russian Federation, there is an urgent need for finding possible ways of building an effective control system for a spatially distributed network-centered air defense missile cover system. The article presents a conceptual approach to the design of the structure that would be effective for controlling such a system, which is based on both the classical construction principles of control systems and the novel network-centric approach to design of control systems. The conceptual approach takes into account the peculiarities of building a spatially distributed tier of air defense missile cover.
Обґрунтування організації зенітного ракетно-артилерійського прикриття угруповань військ з застосуванням міжвидових мобільних вогневих підрозділів ППО
Authors: Ярош С.П. , Рябуха Б.М. , Соломонович Р.А.
Published: May 2020

У статті пропонується однин із шляхів забезпечення ефективного зенітного ракетно-артилерійського прикриття – це його ешелонування, а саме створення та застосування міжвидових мобільних вогневих підрозділів протиповітряної оборони, до складу яких будуть залучені комплекси ЗРВ і військ ППО СВ різної дальності дії. Основними складностями при організації застосування міжвидових мобільних вогневих підрозділів, які потребують дослідження, є: обґрунтування раціонального складу міжвидового мобільного вогневого підрозділу протиповітряної оборони залежно від визначеного завдання; вибір бойового порядку, який забезпечує ефективне застосування створеного підрозділу ППО; порядок організації управління, взаємодії та логістичного забезпечення в міжвидових мобільних вогневих підрозділах ППО.
Пропозиції щодо підвищення ефективності ППО кораблів (катерів) ВМС України в пунктах базування (військово-морських базах) та на переході морем
Authors: Корощенко М.М. , Харитонов О.Л.
Published: May 2020

На основі аналізу бойових можливостей засобів повітряного нападу ВКС Російської Федерації в районі Чорного на Азовського морів та корабельних засобів ППО ВМС України запропоновано та обґрунтовано пропозиції щодо підвищення ефективності ППО кораблів (катерів) ВМС України в пунктах базування (військово-морських базах) та на переході морем.
Administrasi Layanan Khusus
Authors: Nadira Rahmi Suci
Published: May 2020

This article contains the understanding, process and role of the teacher in the administration of special services. Special service administration is to provide special services or a business that is not directly related to the teaching and learning process in the classroom. But specifically given by the school to the students so that they are more optimal in implementing the learning process.
Administrasi Hubungan Sekolah Dan Masyarakat
Authors: Nadira Rahmi Suci
Published: May 2020

This article contains the understanding, principles, processes and role of school personnel in Husemas administration. The existing educational environment that occurs around the education process plays a role and contributes to the process of improving the quality of education. Then the principal must make an effort to make the best use of educational resources, so that all the available sources contribute to the delivery of quality school education
Open Mathematics Knowledge Base
Authors: Lobo Matheus Pereira
Published: May 2020

We present a list of mathematical results for future implementation in a digital Open Mathematics Knowledge Base.
PERANGKAT LUNAK KOMPUTER
Authors: Siregar Azizah Gustina
Published: May 2020

AbstrakPerangkat lunak komputer adalah sekumpulan data elektronik yang disimpan dan diatur oleh komputer, data elektronik yang disimpan oleh komputer itu dapat berupa program atau instruksi yang akan menjalankan suatu perintah. Melalui perangkat lunak inilah suatu komputer dapat menjalankan suatu perintah. Perangkat lunak tidak dapat disentuh dan dilihat secara fisik, software memang tidak tampak secara fisik dan tidak berwujud benda namun bisa untuk dioperasikan.AbstractComputer software is a collection of electronic data that is stored and regulated by a computer, electronic data stored by that computer can be a program or instruction that will execute a command. Through this software a computer can run a command. Software cannot be touched and seen physically, software does not appear physically and is not tangible but can be operated.
Perangkat Lunak (Software)
Authors: Apriani
Published: May 2020

Perangkat lunak (Software) adalah sekumpulan data elektronik yang disimpan dan diatur oleh komputer, data elektronik yang disimpan oleh komputer itu dapat berupa program atau instruksi yang akan menjalankan suatu perintah.
Effective theory approach to the measurement problem
Authors: Icefield William
Published: May 2020

One understanding of the Niels Bohr's interpretation of quantum mechanics suggests that the measurement problem arises because an observer description of reality is incomplete due to lack of complete access to an entire system of observed and observer. In general, an additional and external measuring observer is required to access the entire system. Inevitable entanglement between observers, measurement apparatus and measured objects is key to such an understanding of the measurement problem. Quantum mechanics only provides a complete `incomplete' description of reality. Nevertheless, some issues, especially providing an account of why a preferred measurement basis arises, remain. Replacing relations between observed and observer in relational quantum mechanics with those between effective (approximate) theories, one arrives at a more clear understanding of why the measurement problem arises and how a preferred measurement basis is determined. The measurement problem exists because of measurement apparatus limitations, which only allow us to formulate and verify effective theories that inevitably neglect some details of nature.
The Theory of Humans: Dignity
Authors: Yu Xinzhen
Published: May 2020

If you lose a leg, you will feel undignified in public places; that is to say, a body organ is a dignity of humans. If you are penniless, you will feel undignified everywhere; that is to say, money is a dignity of humans as well. Scientifically, therefore, the word ``dignity'' should be a countable noun; you have many concrete dignities, including your body organs, your children, your wealth, your privacy, your image, and so on; in addition, you need to defend these concrete dignities of yours all your life. With this scientific concept of dignity, this paper can smoothly solve a series of hard problems, including (1) how human ancestors stood up from four-legged animals; (2) why humans got dressed; (3) how humans acquired wisdom; (4) why humans commit suicide; and (5) why humans have developed into what you see today.
THE ROLE OF JAWI TAFSIR IN SOCIO-CULTURAL TRANSFORMATION OF THE NUSANTARA ISLAM: A STUDY ON TARJUMĀN AL-MUSTAFĪD
Authors: Putra D. I. Ansusa , Zikwan Zikwan
Published: May 2020

The attention of researchers about Islam to Nusantara is largely related to the transmission of Islam to Nusantara. Meanwhile, attention to the role of vernacularization of Islamic sciences by Nusantara scholars - including attention to vernacularization of interpretive science - is still limited. This paper with the vernacular concept from A.H. Johns, focused on discussing the role of Jawi Tafsir in the Islamization of Nusantara in the early phases of both the formulation of Islamic Nusantara Islam and the socio-cultural transformation of Nusantara. This article’s frame of reference is in terms of the concepts of enculturation, adoption and cultural adaptation, in which vernacularization occurs in each of these processes. Through studies on the Jawi’s vernacular interpretation, Tarjumān al-Mustafīd, this paper argues that in the early scientific formulation of the Nusantara Islam that transformed the socio-cultural Nusantara, the existence of the Tarjumān al-Mustafīd had a major role. With another Jawi commentaries, Tarjumān al-Mustafīd then became the Nusantara's Islamic identity and proof of Islam with the archipelago's character.
Peranan Teknologi Dan Informasi Dalam Kepemimpinan Di Karang Taruna Kelurahan Harapan Jaya
Authors: Jumawan Jumawan , Hadita Hadita , Khalida Rakhmi
Published: May 2020

Abstract

 

Devotion to the community is one of the mandatory activities that must be implemented by a lecturer as part of Three duties college, which aims to implement and implement the scientific competence that is owned to contribute positively to the needs of the community. Community service activities carried out in Karang Taruna RW.18 Harapan Jaya Subdistrict, North Bekasi Subdistrict West Java Province is a manifestation of the creativity of lecturers and students who want to provide knowledge in the field of information technology and leadership. Because many people, especially young people who lack knowledge that the importance of technology and information needs in the leadership of an organization. The material given in the training of technology and information role in leadership in Karang Taruna RW.18 Harapan Jaya urban village is a socialization, understanding of technology and information needs in leadership in an organization or company. The expected objectives after this training are the young generation in Karang Taruna RW.18 Harapan Jaya urban village can add and apply technology and information on the leadership of an organization or company to achieve the goals of the organization or company.

 

Keywords: Technology and Information, Leadership, Organization.

 

Abstrak

 

Pengabdian kepada masyarakat merupakan salah satu kegiatan wajib yang harus dilaksanakan oleh seorang dosen sebagai bagian dari tri dharma perguruan tinggi yang bertujuan untuk menerapkan dan mengimplementasikan kompetensi keilmuan yang dimiliki guna memberikan kontribusi positif bagi kebutuhan masyarakat. Kegiatan pengabdian masyarakat yang dilaksanakan di Karang Taruna RW.18 Kelurahan Harapan Jaya Kecamatan Bekasi Utara Provinsi Jawa Barat merupakan perwujudan kreativitas dosen dan mahasiswa yang ingin memberikan pengetahuanya di bidang teknologi informasi dan kepemimpinan. Oleh karena banyak diantara masyarakat, khususnya para pemuda-pemudi yang kurang memiliki pengetahuan bahwa betapa pentingnya kebutuhan teknologi dan informasi dalam kepemimpinan suatu organisasi. Materi yang diberikan pada pelatihan peranan teknologi dan informasi dalam kepemimpinan di Karang Taruna RW.18 Kelurahan Harapan Jaya yaitu sosialisasi pemahaman kebutuhan teknologi dan informasi dalam kepemimpinan di suatu organisasi ataupun perusahaan. Tujuan yang diharapkan setelah pelatihan ini para generasi muda di Karang Taruna RW.18 Kelurahan Harapan Jaya dapat menambah dan mengaplikasikan teknologi dan informasi dalam kepemimpinan suatu organisasi atau perusahaan untuk mencapai tujuan organisasi atau perusahaan tersebut.

 

Kata Kunci: Teknologi dan Informasi, Kepemimpinan, Organisasi.
History Teaching and Cultural Hegemony
Authors: Fricke Johanna
Published: May 2020

In the 1960s, facing a series of transformations within Spanish society, the Franco regime modified its self-legitimation strategy and with it its portrayal of the Spanish Civil War. Based on the analysis of nine history textbooks for various levels published between 1954 and 1970, this article demonstrates that, by aiming to neutralize increasing demands for democracy, reconciliation and peace, the Franco regime incorporated elements of the corresponding discourses into its own memory discourse. The later the year of publication and the higher the age of the intended readership, the more signs of this process of incorporation appear in the textbooks. Examples of such traces can be found in the terms used to denote the Spanish Civil War, in the textbooks’ characterizations of the two opposing sides, and in their presentation of both the Francoist governmental system and the development of Spain under Francoism.
American and British Efforts to Democratize Schoolbooks in Occupied Italy and Germany from 1943 to 1949
Authors: Weiner Daniela R. P.
Published: May 2020

During the Allied occupation of the Axis countries, education and the revision of educational materials were seen as a means of ensuring future peace in Europe. Most scholarly literature on this topic has focused on the German case or has engaged in a German-Japanese comparison, neglecting the country in which the textbook revision process was first pioneered: Italy. Drawing primarily on the papers of the Allied occupying military governments, this article explores the parallels between the textbook revision processes in Allied-occupied Italy and Germany. It argues that, for the Allied occupiers involved in reeducation in Italy and Germany, the reeducation processes in these countries were inextricably linked. Furthermore, the institutional learning process that occurred in occupied Italy enabled the more thorough approach later applied in Germany.
Клінічний випадок легеневої гіпертензії, асоційованої з рідкісною хворобою легень
Authors: Radchenko G. D. , Kushnir C. M. , Sirenko Yu. M.
Published: May 2020

This article is clinical presentation of pulmonary hypertension case, associated with rare lung disease – lymphangioleiomyomatosis. There are elucidated: diagnostic criteria of this disease, its prevalence, pathogenesis, including mechanisms of pulmonary hypertension development, clinical presentations and methods of treatment. Authors concluded some special features of this case: rare disease that could be diagnosed by only experienced staff; late patient’s age is atypical for this disease (usual this disease is diagnosed in younger women (childbirth potential age); moderate lung function disorders were accompanied by severe pulmonary hypertension, that needed additional examination in expert center; in spite of general recommendations not to use specific therapy in patients with lung disease the prostaglandins were used in this patient with improving of clinical symptoms. Based on summary of 6th World Symposium on Pulmonary Hypertension (Nice, 2018) there were discussed the particularities of pulmonary hypertension diagnosis and treatment in patients with lung disease or chronic hypoxia (group 3) and their differences with pulmonary arterial hypertension (group 1). It was stressed the necessity of individual approaches in specific therapy using in patients with lung diseases and high pulmonary artery pressure and providing the clinical trials for evaluation of this therapy influence on prognosis.
STUDI KUALITAS DAYA UNTUK BERBAGAI VARIASI LETAK KAPASITOR PADA INSTALASI TENAGA
Authors: T Muh. Yusuf , Sultan Ahmad Rizal , Thaha Sarma
Published: May 2020

Salah satu permasalahan yang umumnya terjadi dalam proses penyaluran energi listrik yaitu rendahnya faktor daya pada sistem khususnya jika digunakan pada tingkat industri, Industri pada umumnya rata-rata menggunakan beban yang bersifat induktif sehingga dalam penerapannya diperlukan daya reaktif sebagai suplay beban induktif  untuk memenuhi kebutuhan pada sistem jaringan distribusi tenaga listrik. Faktor daya rendah dapat mengakibatkan kualitas daya terganggu,  kualitas daya yang buruk maka  akan berdampak  mempengaruhi sistem secara keseluruhan dan dapat merusak peralatan maupun sistem tersebut, Sementara kualitas daya yang baik dapat mengoptimalkan kinerja system jaringan distribusi,peralatan dan beban yang terpasang. Penelitian ini bertujuan untuk memperbaiki kualitas daya pada sistem instalasi tenaga dengan mengambil parameter yang dijadikan sebagai rujukan yaitu nilai faktor daya pada system. Adapun standar parameter sesuaidengan standar yang ditetapkan oleh PUIL dan IEEE. Dalam perbaikan faktor daya terdapat beberapa metode yang dapat digunakan yaitu metode Individual kompensasi, Grup kompensasi, Global kompensasi. Dari beberapa hasil tersebut dapat  disimpulkan bahwa untuk perbaikan faktor daya yang efisien dalam penyaluran daya reaktif maka digunakan kompensator dengan metode individual kompensasi. Ketiga metode diatas dapat dibuktikan dengan menggunakan salah metode simulasi di aplikasi ETAP.
ANALISIS SISTEM PROTEKSI OVERCURRENT RELAY PEMBANGKIT LISTRIK TENAGA UAP PT. MAKASSAR TENE
Authors: Shafar A. Anugrah , Thaha Sharma , Gaffar Ahmad
Published: May 2020

Analisis sistem proteksi overcuurent relay merupakan penelitian yang dilakukan untuk mengetahui besar nilai arus hubung singkat 3 phasa yang terjadi di setiap bus atau titik. Dengan mengetahui nilai arus hubung singkat 3 phasa, penulis dapat menentukan setting yang tepat pada overcurrent relay dalam menangani gangguan hubung singkat yang terjadi serta alur koordinasi yang dilakukan oleh setiap relay. Dalam penelitian yang dilakukan di PT. Makassar Tene ini, titik yang diteliti sebagai gangguan yaitu berada pada bus 1, bus 3 dan bus 7. Perhitungan hubung singkat 3 phasa dilakukan dengan metode perhitungan manual dengan menggunakan matriks impedansi dan simulasi menggunakan Digsilent Powerfactory 15.1.  Hasil perhitungan manual diperoleh arus pada bus 1 sebesar 2,06 kA, bus 3 sebesar 4,6 kA dan bus 7 sebesar 10,5 kA.  Hasil simulasi Digsilent Powerfactory 15.1 diperoleh arus pada bus 1 sebesar 2,3 kA, bus 3 sebesar 4,9 kA dan bus 7 sebesar 9,6 kA. Berdarkan hasil besaran arus hubung singkat, maka setting pada OCR1 sebesar 53 A, OCR2 sebesar 30,82 A, OCR3 sebesar 809,24 A, OCR6 sebesar 44,04 A dan OCR7 sebesar  924,85 A.
Studi Pengaruh Beban Puncak Terhadap Susut Umur Transformator di PT.PLN(Persero) Rayon daya
Authors: Anca Afriansyah , Bakhtiar Bakhtiar , L Ruslan
Published: May 2020

Transformator berfungsi menyalurkan tenaga listrik dengan cara menaikkan atau menurunkan tegangan kemudian menyalurkan dari dari suatu rangkaian listirik ke rangkaian listrik lainnya. Transformator didesain dengan suhu sekitar 20 tetapi beroperasi pada suhu lingkungan 30 di Indonesia, maka transformator tersebut harus disesuaikan pembebanannya. Semakin tinggi suhu setempat semakin pendek operasional dan semakin besar susut umur dari transformator  tersebut.. Pemanasan pada belitan trafo dapat mengkibatkan isolasi menjadi rusak dan kenaikan temperatur minyak akan mengubah sifat serta komposisi minyak trafo. Apabila perubahan-perubahan tersebut dibiarkan akan mengakibatkan nilai isolasi dari minyak menurun. suhu belitan  pada sebuah transformator dapat dipengaruhi oleh besarnya beban serta temperatur lingkungan. Perlu dianalisis nilai suhu belitan pada sebuah transformator berdasarkan standar IEC354 yang diterapkan yaitu maksimal 98ºC.Pada tulisan ini meneliti pengaruh beban puncak terhadap susut umur transformator di PT.PLN (Persero) Rayon Daya. Hasil penelitian diperoleh pembebanan tranformator PT.IBT.007 dan transformator PT.IBT.SPTC masing-masing 90.3 % dan 91.5% . susut umur yang didapatkan sebesar 122% dan 136% sehingga sisa umur transformator diperkirakan 15 tahun dan 12 tahun.
Mechanisms of selected functional foods against viral infections with a view on COVID-19: Mini review
Authors: Haslberger Alexander , Jacob Ursula , Hippe Berit , Karlic Heidrun
Published: May 2020

Following research obtained from the previous SARS and MERS outbreaks, we’ve gained knowledge about the mechanisms of bioactive plant ingredients against the attachment and replication of COVID-19 as well as overshooting immune responses. This could be used for designing COVID-19 trials utilizing bioactive compounds. The receptors for SARS, ACE-2, and CD26 show associations with mechanisms that regulate human senescence. Several functional foods interact with the epigenetic regulation of viral infection and mechanisms of senescence. This review concentrates on the link between bioactive plant ingredients and their activities against mechanisms of viral infections.Keywords: COVID-19, Epigenetic, Quercetin, Curcumin, Epigallocatechin gallate, Phloretin, Berberine
Digitale Objekte. Pilotschulen und die Erprobung neuer Lernmedien
Authors: Kalthoff Herbert , Cress Torsten
Published: May 2020

Der schulische Unterricht ist immer auch ein Experimentierfeld für neue Unterrichtsformen und neue Lernmedien (digitale Objekte), die in der Bildungswirtschaft entwickelt und in kooperierenden Pilotschulen erprobend eingesetzt werden. In Schulen bildet sich somit eine Koexistenz von analogen und digitalen Lernmaterialien aus, die ihre je spezifische Wirkung im Unterricht entfalten. Der Beitrag analysiert die ad-hoc-Erprobung neuer digitaler Lernmedien im Unterricht einer solchen Pilotschule. Der Beitrag zeigt die Faszination der neuen Technologie, die eine Immersion ihrer Nutzer in digital simulierte Gegenstandswelten vornimmt und damit eine Vision von Lernen vermittelt, die den menschlichen Sehsinn privilegiert. Der Beitrag beschreibt und analysiert diese Faszination von technisch erzeugten Bilderwelten auf Seiten der Schüler*innen sowie die Arbeit der Lehrkraft an der Einpassung der neuen Technologie in einen schulisch sinnvollen Rahmen.
„Etwas lernen“ und „Spaß haben“. Modulationen des Umgangs mit der Sache in außerunterrichtlichen Ganztagsangeboten
Authors: Haude Christin , Schütz Anna , Idel Till-Sebastian , Graßhoff Gunther , Bebek Carolin
Published: May 2020

Außerunterrichtliche Angebote bilden einen Schwerpunkt in Ganztagsschulen. In der Ganztagsdebatte werden weitreichende Erwartungen einer Öffnung von Schule an sie adressiert. Die Angebote sollen etwas anderes als „Unterricht“ bieten und sozialpädagogischen Prinzipien wie Partizipation, Freiwilligkeit, Lebensweltorientierung und Alltagsbildung Raum geben. Anders als die standardisierte Forschung zu Prozessqualität und Wirkungen von Ganztagsschule ermöglichen die ethnographischen Beobachtungen aus dem DFG-Projekt JenUs eine Analyse des Binnengeschehens außerunterrichtlicher Angebote. Im Beitrag werden Ergebnisse einer Typenbildung zur Lernkultur vorgestellt, deren tertium comparationis der Fokus auf den Umgang mit der Sache ist. Leitend für die Typenbildung ist die Modulation des Umgangs mit der Sache im Spannungsfeld von „etwas lernen“ und „Spaß haben“. Die Typen werden in Bezug auf ihre Nähe und Ferne zu Formelementen von Unterricht und sozialpädagogischen Angebotslogiken diskutiert. Insgesamt soll damit ein Beitrag zur Forschung über die Diversifizierung der schulischen Lernkultur geleistet werden.
Fotografische Inszenierung einer Praxissituation im Lehramtsstudium – eine Dokumentarische Bildinterpretation
Authors: Trumpa Silke
Published: May 2020

Im vorliegenden Beitrag steht die Analyse einer fotografisch inszenierten Praktikumssituation einer Lehramtsstudentin in der Grundschule im Mittelpunkt. Das Bild illustriert in der Zeitschrift didacta großformatig ein Interview, in dem Neuerungen in der Lehramtsausbildung besprochen werden, deren Umsetzung im Rahmen der Qualitätsoffensive Lehrerbildung eine Rolle spielen sollen. Mittels Dokumentarischer Bildinterpretation wird das enthaltene gesellschaftlich-konjunktive Wissen über die Lehrerbildung herausgearbeitet, das das öffentliche Bild des Berufsstandes konstituiert und prägt. Es zeigt sich auffallend traditionell und enthält Widersprüchlichkeiten, die nicht nur auf die Komplexität des Lehrens und Lernens verweisen, sondern auch als Alltagsverständnis über den Lehrberuf gelesen werden können.
Berufskampagnen als empirisches Datum von Bildern zum Lehrerwerden und Lehrersein – dokumentarische Analyse und professionstheoretische Diskussion von Lehrerbildern in Gratispostkarten
Authors: Matthes Dominique , Damm Alexandra
Published: May 2020

Im Zentrum des vorliegenden Beitrags steht ein explorativer Zugang zu ausgewählten Dokumen¬ten zweier Kampagnen zum Lehrerberuf. Auf der Basis professions- und praxistheoretischer An-nahmen sowie unter Rückgriff auf die Dokumentarische Methode wird aufgezeigt, welche Bilder zum Lehrerwerden und Lehrersein sich mithilfe von Gratispostkarten rekonstruieren lassen, die zum Zweck der Anwerbung für das Lehramt zum Einsatz kommen. Dabei wird zum einen disku¬tiert, wie solche Daten über den gewählten forschungspraktischen Zugang und die empirische Rekonstruktion für die Erforschung des Lehrerberufs fruchtbar gemacht werden können. Zum anderen werden die Befunde der rekonstruierbaren Verhandlungsweisen zum Lehrerberuf mit wesentlichen Annahmen professionstheoretischer Ansätze kontrastiert.