bluuebunny/crossref_metadata_2025 huggingface dataset:
Visceral obesity determined by CT as a predictor of short-term postoperative complications in ovarian cancer
Authors: Nie Xianglin , Zhang Lin , Meng Huangyang , Zhong Yi , Jiang Yi , Chen Ting , Cheng Wenjun
Published: December 2022

Objective: To explore the association between visceral obesity and short-term postoperative complications in patients with advanced ovarian cancer undergoing cytoreductive surgery.
Methods: Medical records were reviewed for patients with advanced epithelial ovarian cancer. Visceral fat area, subcutaneous fat area and total fat area were measured on a single slice at the level of L3/4 of a preoperative CT scan. The Receiver Operating Characteristic (ROC) curve was used to calculate the optimal cut-off value for visceral fat area. Relationships between visceral fat area and characteristics of ovarian cancer patients were analyzed. Univariable and multivariable Logistic regression analyseswere performed to investigate the value of perioperative characteristics of patients on short-term complications.
Results: According to the ROC curve, the best cut-off value of VFA was 93 cm². Of the 130 patients, 53.8% (70/130) were presented visceral obesity. Patients with visceral obesity were older than those with non-visceral obesity (58.4 years old vs. 52.1 years old, p < 0.001). The proportion of patients with hypertension was higher (35.7% vs. 13.3%, p = 0.003). The total fat area and subcutaneous fat area were higher in patients with visceral obesity (294.3 ± 75.5 vs. 176.2 ± 68.7, p < 0.001; 158.9 ± 54.7 vs. 121.7 ± 52.6, p < 0.001). Compared with patients in the non-visceral obese group, patients in the visceral obese group were more likely to have postoperative fever (21/70 30.0% vs. 8/60 1.25%, p = 0.023), leading to a longer length of hospital stay (21 days vs. 17 days, p = 0.009). Time from surgery to adjuvant chemotherapy for patients with visceral obesity has been delayed (24 days vs. 19 days, p = 0.037). Multivariate analysis showed that visceral obesity (OR = 6.451, p < 0.001) and operation time (OR = 1.006, p < 0.001) were independent predictors of postoperative complications.
Conclusion: Visceral obesity is an important risk factor for short-term postoperative complications in patients with advanced ovarian cancer undergoing cytoreductive surgery.
Associations between psychological distress and nursing humanistic care demands in patients with surgical treatment of tumors
Authors: Ma Fengyan , Zhu Yajing , Liu Yan , Liu Lu
Published: December 2022

Background
Psychological distress in cancer patients affects patients' treatment and recovery and reduces their quality of life. Humanistic care can improve patients' psychological situation. However, there is no research related to humanistic care demands and the psychological distress of cancer patients.
Methods
A total of 563 tumor patients from our center were recruited and investigated using a general questionnaire, a psychological distress thermometer (DT), and a humanistic care demand questionnaire.
Results
The average score of psychological distress was (3.75 ± 2.55). There were 256 cases (45.4%) with significant psychological distress (DT ≥ 4). There was a positive correlation between the level of patient psychological distress and nursing humanistic care demand (r = 0.244, P < 0.01). The logistic regression analysis showed that respiratory status, difficulty in arm movement, disrupted daily life, sadness, complaints, tension, and ability to have children were the factors significantly affecting patients' psychological distress (P < 0.05).
Conclusion
The detection rate of psychological distress in patients with surgical treatment of tumors is high. Influenced by various factors, medical staff should pay great attention to patients’ psychological states and take individualized nursing measures to alleviate their psychological distress.
Prevalence of Syphilis and determinants among Female Sex Workers in Ethiopia: A Multilevel Analysis of the National Bio-behavioral Survey Data Using Respondent Driven Sampling
Authors: Tura Jaleta Bulti , Ayalew Jemal , Moreda Ammar Barba , Lulseged Sileshi , Rameto Mohammed Ahmed , Negeri Lemessa , Bedassa Bira Bejiga , Ebo Gemechu Gudeta , Bati Fayiso Wariso , Belihu Wudinesh Belete , Amente Edossa , Haptesellasie Abebe , Tollera Getachew , Hailu Mesay , Abrahim Saro Abdella
Published: December 2022

Background: Syphilis is a highly contagious Sexually Transmitted Infection posing a significant public health challenge, especially in developing countries including those in sub-Saharan Africa. Female sex workers are exposed to sexually transmitted infections, including syphilis, because of their sexual behavior and limited access to health services. There is scarce data on national syphilis prevalence estimate and the associated factors in Ethiopia. This along with our limited knowledge extent of clustering among female sex workers across towns in the country, a critical gap in information we aimed to fill through this analysis.
Methods: The study was a community based cross-sectional, bio-behavioral survey conducted among FSWs in 16 cities and major towns in Ethiopia by using a Respondent Driven Sampling method. Survey data were collected through an interviewer administered questionnaire and blood samples were collected for syphilis, HIV, and hepatitis serological testing from 6085 participants. In this analysis, we employed descriptive statistics to summarize data on the study variables. We used multilevel bivariable and multivariable logistic regression models to examine the association between independent variables and the outcome (syphilis prevalence), while also accounting for the clustering effect.
Result: Of the 6085 female sex workers included in the study, a majority (96.1%) were in the 20-24 years age group. The overall prevalence of syphilis among female sex workers in the 16 cities and major towns of Ethiopia was 6.2%. Being in the age group of 30-34 (AOR=2.64; 95% CI=1.40, 4.98), and 35-59 (AOR=4.7; 95% CI=2.5, 8.86), being divorced/widowed (AOR=1.37; 95% CI=1.03, 1.82), having no formal education (AOR=3.38; 95% CI=2.34, 5.11), primary 1st cycle (grades 1-4) education (AOR=2.77; 95% CI=1.79, 4.30), and having primary 2nd cycle (grades 5-8) education (AOR=1.80; 95% CI=1.21, 2.69) were significantly associated with syphilis infection among female sex workers.
Conclusion: The prevalence of syphilis was high among female sex workers in Ethiopia. Being divorced/widowed or in the older age group, and having low level of education were significantly associated with increased risk of syphilis. The high prevalence and the determinant identified in the study need to be considered in the planning of comprehensive interventions to control syphilis infection among female sex workers in Ethiopia.
Quetiapine effect on depressive-like behaviors, oxidative balance, and inflammation in serum of rats submitted to chronic stress
Authors: Grolli Roberta Eduarda , Bertollo Amanda Gollo , Benhenk João Paulo , Borba Laura de Araujo , Plissari Marcos Eduardo , Soares Silvio José Batista , Manica Aline , Joaquim Larissa da Silva , Petronilho Fabricia , Quevedo João , Bagatini Margarete Dulce , Réus Gislaine Zilli , Ignácio Zuleide Maria
Published: December 2022

Major depressive disorder (MDD) etiology is still not completely understood, and many individuals resist the traditional treatments. Chronic exposure to stressful events can contribute to development and progression and be involved in biological changes underlying MDD. Among the biological mechanisms involved, inflammatory changes and oxidative balance are associated with MDD pathophysiology. Quetiapine, a second-generation antipsychotic, induces a better therapeutic response in individuals refractory to traditional treatments. The main objectives of this research were: To evaluate the effect of chronic mild stress (CMS) on depressive-like behaviors, oxidative stress, and inflammation in adult rats; to evaluate the possible antidepressant, antioxidant and anti-inflammatory effects of quetiapine. The animals were submitted to CMS protocols. At the end of the CMS, the animals were submitted to a chronic treatment for 14 days with the following drugs: quetiapine, imipramine, and escitalopram. At the end of the treatments, the animals were evaluated in the open field tests, anhedonia (splash test), and forced swimming. The animals were euthanized after the behavioral tests, and serum samples were collected. Myeloperoxidase (MPO) activity and interleukin-6 levels were analyzed. CMS induced an increase in depressive-like behaviors, and quetiapine significantly reduced these behaviors. MPO activity and IL-6 levels increased in the serum of animals submitted to CMS. Quetiapine significantly reduced MPO activity and IL-6 levels. These results corroborate other evidence, indicating that chronic stress is a relevant phenomenon in the etiology of depression and suggesting that quetiapine induces an antidepressant effect because it reduces oxidative and inflammatory mechanisms.
The LIFE BAETULO tool: an Integrated Early Warning System for cities to cope with major climate hazards
Authors: Puentes Montse Martinez , Russo Beniamino , Paindelli Andrea , Bofill Joaquin , Lopez-Pinto Paula Recolons , Perez Rubens Hernandez , Carretero Josep Anton Montes
Published: December 2022

LIFE BAETULO (www.life-baetulo.eu) is a European pilot project funded by the EU LIFE Climate Action programme, coordinated by AQUATEC (AGBAR Group) and with a duration of 2.5 years (from July 2020 to December 2022). The main project solution (an Integrated Early Warning System, IEWS) is implemented as a technical and adaptive means to reduce exposure and vulnerability of urban assets and citizens to climate change. IEWS considers major climate change-induced hazards such as floods, combined sewer overflows (CSOs), storm surges, heatwaves, cold waves, snowfalls, windstorms, air pollution and forest fires. The IEWS platform is built on top of existing infrastructure such as meteorological and weather services, drainage infrastructure monitoring systems and official information channels. It is a multi-risk approach, in contrast with classic sectorial solutions which focus on just one hazard at a time. This paper describes the objectives of the project, the architecture of the IEWS, the methodology used for its validation and the expected results and benefits for the city of Badalona.
Comparative Study of Using Elastic Stable Intramedullary Nail (Esin) Versus Rush Pin in Prophylactic Fixation of Femur & Tibia Fractures Among Children With Osteogenesis Imperfecta Cross-sectional Study
Authors: Khairelseed Mohammed Abdelmohsin , Wad-Bador Mustafa Alsheikh , Alrasheed Mohammed khalid
Published: December 2022

Introduction: Recurrent fractures is the most challenging problem in children with Osteogenesis imperfecta, a variety of surgical methods have been investigated to decrease the incidence of this problem.
Objectives: The aim is to compare between the use of Elastic Stable Intramedullary Nail (ESIN) and Rush Pins in order to decrease fracture frequency and asses the complications associated with each method.
Methods: A descriptive cross-sectional study was conducted in 40 children with Osteogenesis imperfecta, the age of the participants was between 3 - 16 years. 20 children with OI were operated using ESIN and 20 children with OI were operated using Rush pin.
Results:Both techniques are effective in guarding against fractures and correcting the deformities. The rate of nail proximal migration was relatively higher in the ESIN group. The re-fracture rate was lower in the Rush rod group. The rate of recurrence of angular deformities were slightly higher in the ESIN group. The reoperation rate was higher in the ESIN group.
Conclusion: Corrective osteotomy with use of (ESIN) or Rush rods works well in guarding against fractures, but the overall complications and reoperation rate is statistically lower when using Rush rods, however both techniques fail to follow bone growth and have a possible complication such as nail proximal migration, recurrence of deformities and also both techniques do need repeated surgeries.
Recommendations: We recommend further studies to assess the outcome between (ESIN, Rush pin) and Telescoping rods, to assess the longevity of these implants and the precise time for exchange and to correlate between surgical interventions with the concomitant use of Bisphosphonates.
Alterations of knee torsion and tibial tubercle torsion after early patellar dislocation in growing rabbits
Authors: Tang Shiyu , Li Weifeng , Wang Shengjie , Wang Fei
Published: December 2022

Background
Torsional factors were considered to be the risk factors for patellar dislocation. But the effects of patellar dislocation for the development knee torsion and tibial tubercle torsion remains unclear. The animal study aimed to investigate whether early patellar dislocation could lead to the alterations of knee torsion and tibial tubercle torsion in growing rabbits.
Methods
In the study, Thirty rabbits (28 days of age) were randomly assigned to two groups. The experimental group comprised 30 left knees which underwent the surgery-induced patellar lateral dislocation. The control group comprised 30 right knees, rabbits did not undergo surgical procedures. Computed Tomography (CT) scan (fexion 0°) was performed after surgery and 5 months post-operatively. The angle of knee torsion, the angle of tibial tubercle torsion and tibial tuberosity-trochlear groove (TT-TG) distance were measured and evaluated between the control group and the experimental group.
Results
The knee torsion, tibial tubercle torsion and TT-TG were not significantly different between the experimental group and the control group after surgery. However, 5 months post-operatively, the angle of knee torsion in the experimental group (41.52 ± 8.43°) and control Group (3.75 ± 2.13°) were significantly different (P < 0.00). The angle of tibial tubercle torsion was found statistically difference in the experimental group (-9.88 ± 2.35°) versus the control group (2.28 ± 1.57°) (P < 0.00). The TT-TG in the experimental group (7.75 ± 2.64 mm) was significantly increased from that control group (1.08 ± 0.45 mm) (P < 0.00).
Conclusion
The results indicated that early patellar dislocation can lead to alterations of knee torsion and tibial tubercle torsion, showing an increased TT-TG in growing rabbits.
Establishment of recombinase polymerase amplification detection method for Puccinia striiformis f. sp. Tritici
Authors: Liu Yaoxia , Hao Jianyun , Guo Qingyun , Yan Jiahui , Yao Qiang
Published: December 2022

Wheat stripe rust caused by Puccinia striiformis f. sp. tritici(Pst)is an airborne disease that endangers the entire growth period of wheat. In this study, the effect of gene PS4593 of Pst was used as the target gene, that PS4593 effector genes have significant virulence functions in wheat, this effector gene could suppress wheat ETI against an avirulent Pst isolate, and the primers PS-RPA-F and PS-RPA-R, as well as the probe PS-LF-Probe, were designed for recombinase polymerase amplification (RPA) technology. Flow chromatography was combined with the process to establish an RPA detection method for Pst. This method could establish visual detection within 10 min under a constant temperature of 39°C, and the detection results were consistent with those of ordinary PCR analysis. This method only had high specificity for Pst, and the detection limit was 10 fg/µL. In addition, this rapid method could detect Pst from wheat leaves during the field incubation period, which has strong benefits in application. In sum, the RPA detection method established in this study has the favorable characteristics of high efficiency, simple functionality, and rapid and universal practicability, which provides a theoretical basis for the early detection and prevention of Pst.
Controllable topological quantum phase transitions in magnetic material FeBi2Te4
Authors: Zhang Jian-Min , Guo Wen-Ti , Yang Ningjing , Huang Zhigao
Published: December 2022

Here, we report a new intrinsic magnetic topological insulator FeBi2Te4 based on first-principles calculations and it can achieve a rich topological phase under pressure modulation. In the absence of pressure, we predict that both FeBi2Te4 ferromagnetic and antiferromagnetic orders are non-trivial topological insulators. Furthermore, FeBi2Te4 of FM-z ordering will undergo a series of phase transitions from topological insulator to semimetals and then to trivial insulator under pressure. Finally, we further clarify and verify the fact of topological phase transitions in conjunction with low-energy effective model calculations. This topological phase transition process is attributed to the synergy of the magnetic moment and the spin-orbit coupling. The unique topological properties of FeBi2Te4 will be of great interest in driving the development of quantum effects.
3D-GBS: A universal genotyping-by-sequencing approach for genomic selection and other high-throughput low-cost applications in species with small to medium-sized genomes
Authors: Ronne Maxime , Légaré Gaétan , Belzile François , Boyle Brian , Torkamaneh Davoud
Published: December 2022

Despite the increased efficiency of sequencing technologies and the development of reduced-representation sequencing (RRS) approaches allowing high-throughput sequencing (HTS) of multiplexed samples, the per-sample genotyping cost remains the most limiting factor in the context of large-scale studies. For example, in the context of genomic selection (GS), breeders need genome-wide markers to predict the breeding value of large cohorts of progenies, requiring the genotyping of thousands candidates. Here, we introduce 3D-GBS, an optimized GBS procedure, to provide an ultra-high-throughput and ultra-low-cost genotyping solution for species with small to medium-sized genome and illustrate its use in soybean. Using a combination of three restriction enzymes (PstI/NsiI/MspI), the portion of the genome that is captured was reduced 4-fold (compared to a “standard” ApeKI-based protocol) while reducing the number of markers by only 40%. By better focusing the sequencing effort on limited set of restriction fragments, 4-fold more samples can be genotyped at the same minimal depth of coverage. This GBS protocol also resulted in a lower proportion of missing data and provided a more uniform distribution of SNPs across the genome. Moreover, we investigated the optimal number of reads per sample needed to obtain an adequate number of markers for GS and QTL mapping (500-1,000 markers per biparental cross). This optimization allows sequencing costs to be decreased by ~ 92% and ~ 86% for GS and QTL mapping studies, respectively, compared to previously published work. Overall, 3D-GBS represents a unique and affordable solution for applications requiring extremely high-throughput genotyping where cost remains the most limiting factor.
Optimal Energy Management Strategy Based on Neural Network Algorithm for Fuel Cell Hybrid Vehicle Considering Fuel cell Lifetime and Fuel Consumption
Authors: Ahmed OMER Abbaker , Wang Haoping , Tian Yang
Published: December 2022

In order to improve the power performance, fuel cell lifetime, and fuel consumption of fuel cell/battery/ supercapacitor powered-vehicle, this paper proposes a new framework of energy management strategy (EMS) consisting of neural network optimization algorithm (NNOA) optimized fuzzy logic controller-based frequency decoupling and adaptive super-twisting sliding mode control based on nonlinear disturbance observer (ASTSMC-NDOB). In the proposed EMS, frequency decoupling based on adaptive low-pass filter and Harr wavelet transform (HWT) using fuzzy logic controllers (FLCs) are employed to decouple the required power into low, medium, and high-frequency components for fuel cell, battery, and supercapacitor, respectively. The proposed frequency decoupling-based strategy can improve the power performance of the vehicle as well as reduce load stress and power fluctuation on fuel cell. In order to precisely optimize membership functions of suggested FLCs, NNOA is adopted to tune them while minimizing the objective function, considering the hydrogen consumption and constraints on the battery/supercapacitor SOC. Furthermore, in order to achieve robustness and high-precision control, the ASTSMC-NDOB controllers are developed to stabilize the DC bus voltage and force currents of the fuel cell, battery, and supercapacitor to track their obtained reference values. The fuel cell hybrid electric vehicle with proposed EMS is modelled on MATLAB/Simulink, and three driving conditions such as HWFET, UDDS, and WLTP driving schedules are used for evaluation. The findings exhibit that the proposed EMS can effectively improve the fuel economy, reduce power fluctuation on fuel cell, and prolong its lifetime compared to state machine strategy and fuzzy logic control-based EMS.
Solvatochromism and third-order nonlinear optical responses of Azo dye
Authors: Anusha B , Rany D Jeancy , Jeyaram S , Kaviyarasu K
Published: December 2022

Third-order nonlinear optical (NLO) properties of acid black 32 (AB 32); an azo dye is studied by sensitive Z‒scan method. The dye is dissolved into various solvents like methanol, acetone, ethanol, water, DMF and DMSO at 0.01 mM concentration. The diode laser with operating wavelength of 650 nm is used to study the third-order NLO characteristics of AB 32 dye. The effect of solvent spectral characteristics on linear absorption coefficient and third-order NLO features of AB 32 dye is studied and multi-parameter scale known as Kamlet-About-Taft is used to analyze the solvent characteristics on solute molecule. The nonlinear refractive index (n2) and nonlinear absorption coefficient (β) of the dye sample is respectively measured to be the order of 10− 7cm2/W and 10− 2 cm/W. The title sample shows both positive and negative nonlinear absorption (NLA) coefficient owing to the phenomenon of saturable and reverse saturable absorption (RSA), as well as negative nonlinear index of refraction as a result of self-defocusing. The order of third-order NLO susceptibility (χ(3)) of AB 32 dye in different polar solvents is measured to be 10─6 esu. The obtained results propose that AB 32 dye is a suitable material for future NLO applications.
Overexpression of IL-6 and STAT3 May Provide New Insights into Ovine Pulmonary Adenocarcinoma Development
Authors: Toma Corina , Popa Roxana , Ciobanu Lidia , Baldea Ioana , Amorim Irina , Bochynska Diana , Wolfe Alan , Negoescu Andrada , Gal Claudiu , Taulescu Marian
Published: December 2022

Background
Ovine pulmonary adenocarcinoma (OPA) is caused by Jaagsiekte sheep retrovirus (JSRV) and is considered the most suitable animal model for human lung cancer. The precise mechanisms of OPA oncogenesis are still uncertain. Signal transducer and activator of transcription 3 (STAT3) is activated by interleukin-6 (IL-6) in many cancers, but this aspect is unknown in OPA. We aimed to evaluate the expression of IL-6 and STAT3 in OPA for its potential role in pulmonary carcinogenesis.
Results
Twenty cases of JSRV-positive OPA and 9 normal lung tissues from sheep were included in the study. Tissue samples were stained with antibodies for IL-6, STAT3, and JSRV-MA. IL-6 and STAT3 were semi-quantified in OPA and control groups using Western Blot (WB). IL‑6 was expressed in stromal, inflammatory, and epithelial cells in all cases of OPA, while STAT3 expression was restricted to epithelial cells. In the OPA group, the percentage of immunolabelled cells for STAT3 accounted for a mean value of 96%. Using the H-SCORE method, 95% of cases were considered positive for STAT3 expression. Control tissuesshowed multifocal andweak immunoexpression for both markers. Using WB analysis, a highly significant amount of both IL-6 (p=0.0078) and STAT3 (p<0.0001) proteins were detected in lung neoplasms compared to controls.
Conclusions
Our data showed overexpression of IL-6 and STAT3 in OPA in comparison with healthylungs. These results suggest a potential role of IL6-STAT3 in OPA carcinogenesis.
Patterns of Peripartum Depression and Anxiety During the Pre-Vaccine COVID-19 Pandemic
Authors: Altendahl Marie R , Xu Liwen , Asiodu Ifeyinwa , Boscardin John , Gaw Stephanie L , Flaherman Valerie J , Jacoby Vanessa L , Richards Misty C , Krakow Deborah , Afshar Yalda
Published: December 2022

Background: Pregnant people are vulnerable to new or worsening mental health conditions.This study aims to describe prevalence and course of symptomatic depression and anxiety in pregnancy during the pre-vaccine COVID-19 pandemic.
Methods:This is a prospective cohort study of pregnant individuals with known or suspected COVID-19. Participants completed Edinburgh Postnatal Depression Scale (EPDS) and Generalized-Anxiety Disorder-7 (GAD-7) questionnaires at 34weeks gestational age, 6-8weeks postpartum, and 6months postpartum. Prevalence of symptomatic depression and anxiety at each visit was described. Univariable logistic regression analysis was used to determine the association between demographic and clinical factors and symptomatic depression or anxiety
Results: 317 participantswere included.The prevalence of antepartum depression was 14.6%, 10.3%, and 20.6% at 34weeks gestational age, 6-8weeks postpartum, and 6months postpartum, respectively. The rate of anxiety was 15.1%, 10.0%, and 17.3% at 34weeks gestational age, 6-8weeks postpartum, and 6months postpartum, respectively. A prior history of depression and/or anxiety (p’s<0.03), as well as higher EPDS and GAD-7 scores at enrollment (p’s<0.04) associated with depression and anxiety throughout pregnancy and the postpartum period. Quarantining during pregnancy was associated with symptomatic anxiety at 34weeks gestational age in univariate (P=0.027) analyses. COVID-19 diagnosis and hospitalization were not associated with depression or anxiety.
Conclusions: Depression and anxiety were prevalent throughout pregnancy and the postpartum period, particularly in those with prior depression and/or anxiety and who quarantined. Strategies that target social isolation may mitigate potential adverse consequences for pregnant people, and continued vigilance in recognition of depression and anxiety in pregnancy should be considered.
The COMPASS subunit Spp1 protects nascent DNA at stalled replication fork barrier by limiting DNA availability to nucleases
Authors: Ghaddar Nagham , Corda Yves , Luciano Pierre , Galli Martina , Doksani Ylli , Geli Vincent
Published: December 2022

Homologous recombination factors play a crucial role in protecting nascent DNA during replication but the role of chromatin in this process is largely unknown. Here, we used the bacterial Tus/Ter barrier known to induce a site-specific replication fork stalling in S. cerevisiae. We report that the COMPASS subunit Spp1 is recruited behind the stalled replication fork independently of its interaction with Set1. Spp1 chromatin recruitment depends on the interaction of the Spp1 PHD domain with H3K4me3 parental histones deposited behind the stalled fork. Its recruitment prevents accumulation of ssDNA at the stalled fork by restricting the access of Exo1. We further show that deleting SPP1 accelerates fork progression and increase mutation rate upstream the barrier consistent with ssDNA accumulation. Finally, we report that Spp1 protects nascent DNA at challenged replication forks. We propose that Spp1 limits remodeling of the fork that ultimately limits nascent DNA availability to nucleases.
Du Fort-Frankel Finite Difference Scheme for Solving of Oxygen Diffusion Problem Inside One Cell
Authors: BOUREGHDA Abdellatif , Djellab Nadjate
Published: December 2022

In this paper, we use the well-known Du Fort-Frankel finite difference scheme to solve the oxygen diffusion problem inside one cell which is modeled by an initial moving boundary value problem for one dimensional time-dependent partial differential equation. The main problem consists in tracking the moving boundary that represents the oxygen penetration depth inside the cell. We explore the possibilities of numerical approximation of the problem posed by the different formulations. Some numerical experiments are also provided with comparisons with analytical solution.The theoretical analysis is given for the numerical scheme. It is shown that all the results obtained by this method are compared with earlier authors.
AMS Subject Classification: 35R35; 35R37; 80A22; 65M06; 65N06.
Biomechanical evaluation of implant system fixed dentures support in atrophic maxilla
Authors: Coelho Katherine , Mota Leonardo , Lameira Aladim , Vedana Deborah , Zavaglia Cecília , Dias Carmen
Published: December 2022

Patients with atrophic maxilla are a challenge, since this condition can compromise the installation of implants. Hybrid implants system made by CAD/CAM, installed in the zygomatic and canine pillars bilaterally. The AL system consists of mini plates connected in a prosthetic abutment that is screwed into an implant-supported complete denture. There was performed a biomechanical evaluation of the AL system under mastication load simulation. A model of a patient's bone was built using In Vesalius software, exported, and treated in a CAD system. The AL implants and the prosthesis fixation bar were modeled based on the Bio model’s geometry. A structural static simulation of the bar was carried out and the supportive reactions were applied on the implants. The simulation was performed for a critical chewing load of 756 N. In this case, the maximum von Mises tension in the fixation bar and the minimum safety factor were respectively 366 MPa and 1.91. In a simulation of a 5 times lower load total edentulous chewing load, the safety factor was 9.55 and 17.10 for the fixation bar and the implants. The fixation bar and implants have the capacity to withstand the stresses to which they will be subjected during chewing.
Health facilities preparedness to deliver maternal and newborn health care in Kilifi and Kisii Counties, Kenya
Authors: Orwa James , Temmerman Marleen , Nyaga Lucy , Mulama Kennedy , Luchters Stanley
Published: December 2022

Introduction: Health facility preparedness to deliver quality maternal and newborn care reduces maternal and newborn morbidity and mortality by avoiding the three delays (delay in deciding to seek care from a skilled attendant by pregnant woman; delay in reaching the facility with capacity to offer basic emergency obstetric care; and delay in receiving emergency care upon reaching a health facility). Rapid assessment and review of previous health records has shown that 16 health facilities in rural Kenya had poor maternal and newborn indicators. As a result, support was given to these facilities by providing basic emergency obstetric and newborn care (BEmONC) and comprehensive emergency obstetric and newborn care (CEmONC) training to providers, provision of equipment and supplies, and strengthening referral linkages. This study described the preparedness of the facilities to deliver maternal and newborn health care services at the end of the project implementation.
Methods: A descriptive cross-sectional study was conducted in targeted rural counties of Kilifi and Kisii counties in December 2019 covering 16 Government of Kenya (GoK) health facilities to describe the preparedness of the facilities to deliver maternal and newborn healthcare services by examining the availability of drugs, commodities, equipment, staffing, general requirements (water and electricity, and guidelines), and the ability to perform. The results of the assessment are described using frequency and percentages, and comparative synthesis.
Results:
All of the 16 facilities were offering routine ANC and normal vaginal delivery services, however only two were providing CEmONC services. Most of the essential medicines and commodities were available in most of the health facilities as well as the required equipment. BEmONC and CEmONC guidelines were available in Kilifi health facilities and none in Kisii. There was only one staff in each county available 24/7 for Caesarian Section (CS) and only one anesthetist available in Kilifi. Electricity was available in all the facilities, however only half had secondary power supply. All the facilities offering CS were equipped with generators as a secondary power back-up.
Conclusion:
The health facilities reported availability of most of the drugs, commodities, and equipment than on general requirements as per their level of operation, however staffing and guidelines were limited. Facilities in Kilifi performed better than in Kisii. To deliver quality maternal and newborn health services, more support is required towards general infrastructure and human resources. Continuous monitoring of these services will help in the allocation of resources based on the need of the health facilities.
Influence of different skew angles of the submerged vane on pressure flushing performance
Authors: Beiramipour Sepideh , Qaderi Kourosh , Rahimpour Majid , Kantoush Sameh A. , Hghjouei Hadi
Published: December 2022

Siltation is a major threat to the original storage capacity and lifespan of a reservoir. Pressure flushing is an effective measure against siltation through the partial drawdown of the reservoir water level with limited flushed cone volumes in front of the bottom outlet. In this study, a novel configuration with submerged vanes has been proposed and tested experimentally to increase the flushed sediment volume during the pressure flushing operation. In the new configuration, submerged vanes aligned with ten skew angles (θ) of 10°, 20°, 30°, 45°, 70°, 110°, 135°, 150°, 160°, and 170° to flow direction in non-cohesive sediment bed materials were conducted. The results showed that in 45° ≤ θ ≤ 160°, increasing the skew angle increased the flushing cone geometry. The minimum and maximum flushing cone dimensions and volume occurred at skew angles of θ = 45° and 135° ≤ θ ≤ 160° around the bottom outlet. Eventually, nonlinear regression analysis yielded an equation for estimating flushing cone volumes. The developed equation was tested in real case studies of a target reservoir, and an acceptable correlation between calculated and experimental results was obtained.
Navigating Newcomers’ Food Transitions in the COVID-19 Pandemic: A developmental evaluation of a community-based program
Authors: Hanjahanja-Phiri Thokozani , Buchan Claire , Butler Alexandra , Doggett Amanda , Romano Isabella , Centre Sanctuary Refugee Health , Neufeld Hannah , Janes Craig
Published: December 2022

Refugee newcomers almost invariably face “food” culture shock and are at greater risk of food insecurity due to slow-to-evolve institutions. Community programs can help boost refugee newcomer confidence through knowledge exchange during intercultural culinary experiences. The originally proposed program was “Breaking Down the Walls (BDTW) - Building Integration and Cultural Appreciation through Shared Food Experiences with Refugee Newcomers”. With the restrictions set in place due to the COVID-19 pandemic, adaptations were made to the BDTW program. Specifically, the program’s scope was greatly reduced and the program itself shifted to a virtual environment. The final deliverables for this program included: 1) a framework/guide for conducting intercultural cooking events; and 2) an Online cultural brokerage training tool to help users to grasp some of the food-related challenges faced by newcomers to Canada. To best identify the challenges, successes, and efficacy of conducting community-based research, the team adopted a Developmental Evaluation approach, which is often used in complex settings and evolving scenarios such as the COVID-19 pandemic. The themes which emerged from interviews with participants were further distilled into broader areas of the COVID-19 pandemic, collaboration, and equity. Programs like BDTW have the potential to create infrastructure for newcomer nutrition programming that is integrated and streamlined as a long-term intervention. This type of programming would help shift care practices from sporadically addressing health/nutrition and settlement issues as they arise to a system that proactively anticipates nutritional needs from day one, ultimately promoting long-term health and mental wellbeing among newcomer populations.
Transcriptional profiling of canine osteosarcoma identifies prognostic gene expression signatures with translational value for humans
Authors: Mannheimer Joshua , Tawa Gregory , Gerhold David , Braisted John , Sayers Carly , McEachron Troy , Meltzer Paul , Mazcko Christina , Beck Jessica , LeBlanc Amy
Published: December 2022

Spontaneous canine osteosarcoma is increasingly recognized as an informative model for human osteosarcoma research. However, additional knowledge is needed to appreciate how well canine osteosarcoma recapitulates the disease in humans, given the significant heterogeneity and genomic complexity of this tumor. Here we show in one of the largest clinically annotated canine osteosarcoma datasets that two previously reported gene signatures cluster the data into two groups that are prognostic for both disease-free interval and overall survival. Furthermore, these signatures are similarly predictive of progression-free and overall survival when applied to a comparable human dataset, NCI-TARGET. Further analysis of both the human and canine clusters reveals similar patterns of activities among immune related pathways and populations of immune cells such as T-cells and macrophages. Collectively these findings further validate the naturally occurring osteosarcoma of the pet dog as a translationally relevant patient model for humans and improve our understanding of the immunologic and genomic landscape of the disease in both species.
An Experience-Sampling investigation of Job Resources, Emotions and Job Performance
Authors: Wang Kexin , Fan Yangyang , Zhang Shuhua
Published: December 2022

Based on the affective event theory and the job demand-resource model, this study explored the impact of daily job resources on job performance through the mediation of emotions from the perspective of intra-individual dynamics. 580 valid data were obtained through a follow-up survey of 58 counselors over a period of 10 working days based on the experience-sampling method (ESM). The results show that: (1) daily work resources have a significant positive effects on daily work performance, daily positive mood, and daily negative mood; (2) daily positive emotions have significant and positive effect on daily job performance, while daily negative emotions shown insignificant effect on daily job performance; (3) daily positive emotions partially mediate the positive relationship between daily work resources and job performance, whereas daily negative emotions did not shown significant mediating effect. This study explored the antecedent of job performance from a micro-mechanism perspective and has contributions both in theory and management practice.
Magnetic mechanical properties of pipeline steel and stress detection of oil and gas pipelines based on magnetic stress coupling
Authors: Weng Guangyuan , Ding Junfeng , Cao Jingting , Hui Yang
Published: December 2022

Complexity of service environment and particularity of the transportation medium make it difficult to develop a nondestructive stress testing on oil and gas pipelines in real time and online. In this case, a stress detection method of oil and gas pipelines is proposed in this work based on the magnetic mechanical properties of pipeline steel materials and the magnetic induction intensity stress coupling relationship. Six commonly used pipeline steels (X52, X56, X60, X65, X70, and X80) are selected as the research objects to test the hysteresis curves. The key parameters of local magnetization of oil and gas pipelines are determined based on their magnetic properties. A finite element simulation model is established for oil and gas pipelines with magnetic field and stress field coupling. The magnetic field distribution and magnetic induction intensity along the length of the pipeline and the height of cross section are studied after local magnetization of the simulation model of oil and gas pipelines unpressurized. The mechanism of magnetic induction intensity and stress variation of the simulation model of oil and gas pipelines with different internal pressures are discussed. The coupling relationship of axial stress, circumferential stress, and magnetic induction intensity are separately established. The systems for stress-strain test and magnetic induction intensity test are integrated to test the X80 pipeline steel. Analysis results on test data and finite element simulation data verify the validity of magnetic coupling simulation of oil and gas pipelines and the reliability of stress detection, which provides a theoretical basis for the key technologies of nondestructive online stress detection of oil and gas pipelines.
Mechanisms and predictors of menses resumption once normal weight is reached in Anorexia Nervosa
Authors: GALUSCA Bogdan , GAY Aurélia , BELLETON Gwenaëlle , EISINGER Martin , MASSOUBRE Catherine , LANG François , GROUSELLE Dominique , ESTOUR Bruno , GERMAIN Natacha
Published: December 2022

Background: In Anorexia Nervosa (AN), association of weight gain recovery above WHO’s lower limits, and classical nutritional markers normalization appears to be mandatory, but not always sufficient, to restore menses. This may worry both patient and practitioner and disrupt medical care. Therefore, this study was designed to evaluate the ability of anthropometric and hormonal factors to predict menses resumption in anorexia nervosa once normal weight was normalized.
Method: AN patients recovering a normal BMI but not their menses (ANRec) were evaluated twice, at visit 1, and 6 months later if bodyweight was maintained over this period (visit 2). The 46 ANRec patients reaching visit 2 were separated into two groups: 20 with persistent amenorrhea (PA-ANRec) and 26 with recovered menses (RM-ANRec). Anthropometric and plasma levels of several hormones, Luteinizing Hormone (LH) pulse and LH response to gonadotrophin releasing hormone (GnRH) injection were then compared between groups at visit 1.
Results: RM-ANRec presented with higher plasma level of follicular Stimulating hormone (FSH), Estradiol, inhibin B, LH/GnRH and ghrelin compared to PA-ANRec. ROC curves analyses showed that LH pulses’ number ≥2, LH/GnRH ≥ 33 UI/l and Inhibin B >63 pg/ml predicted menses resumption with high specificity (87, 100 and 100% respectively) and sensitivity (82, 80 and 79% respectively).
Conclusions: LH pulses’ number≥2, LH/GnRH≥33UI/l or Inhibin B≥63pg/ml can predict accurately menses resumption in still amenorrheic weight-normalized AN patients if they do not lose weight nor practice intense exercise. Negative parameters could help clinician and patient to maintain efforts to achieve individual metabolic set-point.
Toxicity evaluation of the contaminated area of Crotone from biological indicators: a multispecies approach
Authors: Mastroberardino Anna , Casaburi Filomena , Canino Rosario , Iannone Michelangelo , Procopio Salvatore
Published: December 2022

Contamination of terrestrial and aquatic ecosystems by toxic industrial waste has become a major issue in many countries. Of particular concern is the reuse of toxic hazardous waste in construction materials. This paper examined for the first time the chemical and radiation ecotoxicity of site-specific Technological Enhanced Naturally Occurring Radioactive Materials (TENORM) residues from phosphate processing industry in soil environmental matrices through bioindicators. The area under investigation was the former industrial district of Crotone (Calabria, Italy), recently included within the Sites of National Interest (SIN), comprising the 42 Italian national priority contaminated sites. Major biological exposure pathways considered were absorption and bioaccumulation. The marine bacterium Vibrio fischeri and the freshwater crustacean Daphnia magna were employed as aquatic bioindicators, while for the soil ecosystem the seeds of Sorghum saccharatum and Lepidium sativum were used. The selection of test species aimed at assessing the toxicity of wastes in soil as well as in freshwater or marine systems. Results indicated Vibrio fischeri as the most sensitive of all the species tested (5.56 g/L), while Daphnia magna was found to be affected at 94.27 g/L. An overall inhibition was observed in seedling growth as compared to control at the highest concentration of the pollutants (100 g/L), while seed germination was not adversely affected by the pollutant. At this preliminary level, data indicated a potential risk for biodiversity of the area. In fact, the measured toxicity thresholds, even below 100 mg/L, are comparable to concentrations of the toxicants spread all over the territory of Crotone.
Diagnostic Value of SMARCE1 and CRISP3 Combined with Tumor Markers in Cervical Cancer
Authors: He Lijie , Wang Jing , Zhang Heping
Published: December 2022

Objective
To investigate the diagnostic value of SMARCE1, cysteine-rich secreted protein 3 (CRISP3) combined with tumor markers in the diagnosis of cervical cancer.
Methods
A total of 80 patients with cervical lesions who were diagnosed and treated in our hospital from January 2020 to March 2022 were selected and divided into control group (chronic cervicitis, n = 30) and observation group (cervical cancer, n = 50). Immunohistochemistry was used to detect the expression levels of SMARCE1 and CRISP3 in cervical tissue of the two groups of subjects, and the relationship between the expression of SMARCE1 and CRISP3 in cervical cancer tissue and the clinicopathological data of the patients was analyzed. In addition, the serum tumor marker levels of the two groups of subjects were detected, and the diagnostic value of SMARCE1 and CRISP3 combined with tumor markers in cervical cancer was analyzed.
Results
The positive expression rates of SMARCE1 and CRISP3 in the observation group were significantly higher than those in the control group (P < 0.05). There was no significant difference in the positive expression of SMARCE1 and CRISP3 among cervical cancer patients with age, lymph node metastasis and TNM stage (P > 0.05), and the lower the degree of tumor differentiation, the higher the positive expression rate of SMARCE1 and CRISP3 proteins (P < 0.05). The serum levels of CEA, CA125 and CA153 in the observation group were significantly higher than those in the control group (P < 0.05). The results of ROC curve analysis showed that the AUC values of SMARCE1, SMARCE1 + tumor markers, CRISP3, CRISP3 + tumor markers, SMARCE1, CRISP3 combined with tumor markers for the diagnosis of cervical cancer were 0.760, 0.851, 0.739, 0.810, and 0.944, respectively.
Conclusion
SMARCE1 and CRISP3 are expressed in patients with cervical cancer, and CEA, CA125, and CA153 are expressed at high levels in the serum of patients with cervical cancer. The combined detection of SMARCE1 and CRISP3 combined with tumor markers has high clinical diagnostic value for cervical cancer.