bluuebunny/crossref_metadata_2025 huggingface dataset:
Perception and discrimination of real-life emotional vocalizations in early blind individuals
Authors: Ferrari Chiara , Arioli Maria , Atias Doron , Merabet Lotfi B. , Cattaneo Zaira
Published: May 2024

Introduction

The capacity to understand others’ emotions and react accordingly is a key social ability. However, it may be compromised in case of a profound sensory loss that limits the contribution of available contextual cues (e.g., facial expression, gestures, body posture) to interpret emotions expressed by others. In this study, we specifically investigated whether early blindness affects the capacity to interpret emotional vocalizations, whose valence may be difficult to recognize without a meaningful context.

Methods

We asked a group of early blind (N = 22) and sighted controls (N = 22) to evaluate the valence and the intensity of spontaneous fearful and joyful non-verbal vocalizations.

Results

Our data showed that emotional vocalizations presented alone (i.e., with no contextual information) are similarly ambiguous for blind and sighted individuals but are perceived as more intense by the former possibly reflecting their higher saliency when visual experience is unavailable.

Disussion

Our study contributes to a better understanding of how sensory experience shapes ememotion recognition.
Leo program, a short multi-family skill-based psychoeducational program for caregivers of relatives living with a severe mental disorder: a retrospective pilot study
Authors: Lespine Louis-Ferdinand , de Martène Bénédicte , Zeltner Blandine , Chenu Bénédicte , Berbey Céline Dubien , Rey Romain
Published: May 2024

Background

Caring for a relative with a severe mental disorder (SMD) is associated with high levels of burden and poor physical and mental health. There is a dire need for family psychoeducational programs that can be provided as early as possible. This manuscript describes the pilot testing of “Leo” a motivational-based psychoeducational program for caregivers of individuals with a SMD. The Leo program aims to provide caregivers with skills to best support their relative and to adopt self-care behaviors.

Methods

We retrospectively analyzed medical records of caregivers who enrolled in a short, multi-family, skill-based psychoeducational program, consisting of eight 3-hour sessions over 8 weeks. Outcomes of interest included: i) adherence to the program, ii) satisfaction and perceived usefulness, and iii) pre-post changes in self-reported levels of depression (CES-D), burden (ZBI), and skills (10 Likert-scaled items). A network analysis was used to investigate the relationships between pre-post changes in self-evaluated skills and pre-post changes in burden and depression levels.

Results

Over the 91 enrolled participants, 87 (95.6%) completed the program attending at least 5/8 sessions, 80.5% attending all sessions. Seventy-six caregivers fulfilled the questionnaires at baseline and after the program, and were included in the analysis. Although there was no evidence for significant change in self-reported depression levels (Cohen’s d=0.19, p=0.210), burden scores and all evaluated skills were improved post-intervention, with medium to strong effect size (Cohen’s ds from 0.47 to 0.87; p<0.001). Network output indicated that increased self-evaluated competence in 5 skills were associated with a global improvement in caregivers’ burden and/or depression scores. Post-intervention, 89.7% of caregivers were “very satisfied” and 82.1% found the program “extremely useful”.

Conclusion

This pilot retrospective study shows high levels of satisfaction, perceived usefulness, and adherence to “Leo”, a short, multi-family, skill-based psychoeducational program with promising results in improving caregivers’ burden, self-evaluated competence in coping with caregiving demands and in self-care behaviors. This study provides preliminary insights into the mechanisms by which family psychoeducation might alleviate burden of care. A larger-scaled, controlled, randomized study with follow-up assessments is warranted to determine how burden, depression, and skills, as well as their inter-relationships, evolve over time.
Examining childhood experiences and personality functioning as potential predictors for the speed of recovery during psychotherapy of patients with anxiety disorders
Authors: Nowak Jonathan , Nikendei Christoph , Rollmann Ivo , Orth Maximilian , Friederich Hans-Christoph , Kindermann David
Published: May 2024

Background

Adverse childhood experiences were previously identified as relevant risk factors for the development of anxiety disorders. Furthermore, anxiety disorders were shown to be associated with impairments of personality functioning. The objective of this study was to investigate adverse and protective childhood experiences as well as personality functioning, as defined by the Operationalized Psychodynamic Diagnosis system, as potential predictors for the speed of recovery during psychotherapy for patients with anxiety disorders.

Methods

The sample consisted of n = 312 completed psychotherapies. The speed of recovery, defined as symptom abatement over time, was calculated using a two-stage hierarchical linear model. The effects of adverse and protective childhood experiences as well as personality functioning on the speed of recovery during psychotherapy were then examined using a structural equation model.

Results

The presence of adverse childhood experiences predicted a lower speed of recovery during psychotherapy. In addition, a higher number of adverse childhood experiences was associated with greater impairments in the abilities of perception and regulation as dimensions of personality functioning. A higher number of protective childhood experiences was associated with fewer impairments in the communication and attachment dimensions. Impairments in personality functioning in patients with anxiety disorders did not predict the speed of recovery during psychotherapy.

Conclusions

Among patients with anxiety disorders, adverse childhood experiences lead to a lower speed of recovery during psychotherapy. Therefore, childhood adversity should be routinely assessed before and thoroughly addressed during psychotherapy in patients with anxiety disorders.
Clinical and serological predictors of post COVID-19 condition–findings from a Canadian prospective cohort study
Authors: Collins Erin , Galipeau Yannick , Arnold Corey , Bhéreur Anne , Booth Ronald , Buchan Arianne C. , Cooper Curtis , Crawley Angela M. , McCluskie Pauline S. , McGuinty Michaeline , Pelchat Martin , Rocheleau Lynda , Saginur Raphael , Gravel Chris , Hawken Steven , Langlois Marc-André , Little Julian
Published: May 2024

Introduction

More than 3 years into the pandemic, there is persisting uncertainty as to the etiology, biomarkers, and risk factors of Post COVID-19 Condition (PCC). Serological research data remain a largely untapped resource. Few studies have investigated the potential relationships between post-acute serology and PCC, while accounting for clinical covariates.

Methods

We compared clinical and serological predictors among COVID-19 survivors with (n = 102 cases) and without (n = 122 controls) persistent symptoms ≥12 weeks post-infection. We selected four primary serological predictors (anti-nucleocapsid (N), anti-Spike, and anti-receptor binding domain (RBD) IgG titres, and neutralization efficiency), and specified clinical covariates a priori.

Results

Similar proportions of PCC-cases (66.7%, n = 68) and infected-controls (71.3%, n = 87) tested positive for anti-N IgG. More cases tested positive for anti-Spike (94.1%, n = 96) and anti-RBD (95.1%, n = 97) IgG, as compared with controls (anti-Spike: 89.3%, n = 109; anti-RBD: 84.4%, n = 103). Similar trends were observed among unvaccinated participants. Effects of IgG titres on PCC status were non-significant in univariate and multivariate analyses. Adjusting for age and sex, PCC-cases were more likely to be efficient neutralizers (OR 2.2, 95% CI 1.11–4.49), and odds was further increased among cases to report deterioration in quality of life (OR 3.4, 95% CI 1.64–7.31). Clinical covariates found to be significantly related to PCC included obesity (OR 2.3, p = 0.02), number of months post COVID-19 (OR 1.1, p < 0.01), allergies (OR 1.8, p = 0.04), and need for medical support (OR 4.1, p < 0.01).

Conclusion

Despite past COVID-19 infection, approximately one third of PCC-cases and infected-controls were seronegative for anti-N IgG. Findings suggest higher neutralization efficiency among cases as compared with controls, and that this relationship is stronger among cases with more severe PCC. Cases also required more medical support for COVID-19 symptoms, and described complex, ongoing health sequelae. More data from larger cohorts are needed to substantiate results, permit subgroup analyses of IgG titres, and explore for differences between clusters of PCC symptoms. Future assessment of IgG subtypes may also elucidate new findings.
Physical frailty identification using machine learning to explore the 5-item FRAIL scale, Cardiovascular Health Study index, and Study of Osteoporotic Fractures index
Authors: Yang Chen-Cheng , Chen Po-Hong , Yang Cheng-Hong , Dai Chia-Yen , Luo Kuei-Hau , Chen Tzu-Hua , Chuang Hung-Yi , Kuo Chao-Hung
Published: May 2024

Background

Physical frailty is an important issue in aging societies. Three models of physical frailty assessment, the 5-Item fatigue, resistance, ambulation, illness and loss of weight (FRAIL); Cardiovascular Health Study (CHS); and Study of Osteoporotic Fractures (SOF) indices, have been regularly used in clinical and research studies. However, no previous studies have investigated the predictive ability of machine learning (ML) for physical frailty assessment. The aim was to use two ML algorithms, random forest (RF) and extreme gradient boosting (XGBoost), to predict these three physical frailty assessment models.

Materials and methods

Questionnaires regarding demographic characteristics, lifestyle habits, living environment, and physical frailty assessment were answered by 445 participants aged 60 years and above. The RF and XGBoost algorithms were used to assess their scores for the three physical frailty indices. Furthermore, feature importance and Shapley additive explanations (SHAP) were used to determine the important physical frailty factors.

Results

The XGBoost algorithm obtained higher accuracy for predicting the three physical frailty indices; the areas under the curve obtained by the XGBoost algorithm for the 5-Item FRAIL, CHS, and SOF indices were 0.84. 0.79, and 0.69, respectively. The feature importance and SHAP of the XGBoost algorithm revealed that systolic blood pressure, diastolic blood pressure, age, and body mass index play important roles in all three physical frailty models.

Conclusion

The XGBoost algorithm has a more accurate predictive rate than RF across all three physical frailty assessments. Thus, ML can be a useful tool for the early detection of physical frailty.
Analyzing the impact of unemployment on mental health among Chinese university graduates: a study of emotional and linguistic patterns on Weibo
Authors: Tan Miaoqing , Wu Zhigang , Li Jin , Liang Yuxi , Lv Wenting
Published: May 2024

Purpose

This study explores the intricate relationship between unemployment rates and emotional responses among Chinese university graduates, analyzing how these factors correlate with specific linguistic features on the popular social media platform Sina Weibo. The goal is to uncover patterns that elucidate the psychological and emotional dimensions of unemployment challenges among this demographic.

Methods

The analysis utilized a dataset of 30,540 Sina Weibo posts containing specific keywords related to unemployment and anxiety, collected from January 2019 to June 2023. The posts were pre-processed to eliminate noise and refine the data quality. Linear regression and textual analyses were employed to identify correlations between unemployment rates for individuals aged 16–24 and the linguistic characteristics of the posts.

Results

The study found significant fluctuations in urban youth unemployment rates, peaking at 21.3% in June 2023. A corresponding increase in anxiety-related expressions was noted in the social media posts, with peak expressions aligning with high unemployment rates. Linguistic analysis revealed that the category of “Affect” showed a strong positive correlation with unemployment rates, indicating increased emotional expression alongside rising unemployment. Other categories such as “Negative emotion” and “Sadness” also showed significant correlations, highlighting a robust relationship between economic challenges and emotional distress.

Conclusion

The findings underscore the profound impact of unemployment on the emotional well-being of university students, suggesting that economic hardships are closely linked to psychological stress and heightened negative emotions. This study contributes to a holistic understanding of the socio-economic challenges faced by young adults, advocating for comprehensive support systems that address both the economic and psychological facets of unemployment.
Composition and influencing factors of professionals’ capacity in public health emergency rescues: a qualitative study
Authors: Zhong Fangfang , Lin Yin , Chen Ying , Gao Yazhuo , Zhu Xuehua
Published: May 2024

Objective

To explore the composition and influencing factors of professionals’ capacity in public health emergency rescues.

Methods

A descriptive qualitative design was used in this study. Medical workers, managers, and members of an emergency rescue team in Hangzhou, Zhejiang, were recruited for participation through a purposive sampling method. The data were collected using semi-structured interviews and analyzed using a conventional content analysis method.

Findings

A total of 2 themes and 13 sub-themes emerged from the analysis: ability composition (knowledge reserve, early warning assessment, information reporting, emergency response, self-protection, personal ability, coordination and cooperation, health education) and influencing factors (educational background, region, experience, hospital level, human resources, and financial investment).

Conclusion

These findings offer a basis for the construction of a related indicator system and provide a reference for relevant departments to further optimize their emergency education and training, strengthen their emergency drills, and improve their emergency rescue abilities. The findings indicate that it is necessary to pay attention to the construction of an emergency rescue team, adjust the ratio of personnel, improve their remuneration, and promote work enthusiasm to improve the emergency rescue ability of an organization.
Original article: novelty of Canadian manufacture nasopharyngeal swabs for collection of samples being tested for SARS-CoV-2 in a pandemic setting
Authors: Palomino-Padilla Sandra , Caceres-Cardenas Guillermo , Calderon Rodrigo , Ko Alex C-T. , Garnett Lauren , Doan Kaylie , Chong Patrick , Lino Hammerly , Caceres Tatiana , Veres Teodor , Dos Santos Claudia C. , Nielsen Birgit , Ugarte-Gil Cesar
Published: May 2024

Objectives

The COVID-19 pandemic caused a global shortage of nasopharyngeal (NP) swabs, required for RT-PCR testing. Canadian manufacturers were contacted to share NP swab innovations. The primary objective was to determine whether novel NP test swabs were comparable to commercially available swabs regarding user characteristics, ability to collect a specimen, and diagnostic performance using RT-PCR testing.

Methods

Participants were randomized by swab (test/control) and nostril (left/right). A calculated positive percent agreement ≥90% was considered successful. Mean Ct values of viral genes and housekeeping gene (RNase P) were considered similar if a Ct difference ≤ 2 between control and test group was obtained. There also was a qualitative assessment of swabs usability.

Results

647 participants were enrolled from Huaycan Hospital in Lima, Peru, distributed over 8 NP swabs brands. Seven brands agreed to share their results. There were no statistically significant differences between the test swabs of these 7 brands and control swabs.

Conclusion

All the seven brands are comparable to the commercially available flocked swabs used for SARS-CoV-2 regarding test results agreement, ability to collect a specimen, and user characteristics.
Rational or altruistic: the impact of social media information exposure on Chinese youth’s willingness to donate blood
Authors: Zhang Zhijian , Liu Qilong
Published: May 2024

Background

Non-remunerated blood donation is the main approach for various medical institutions to get the source of blood supply, but the blood supply shortage is still a problem in today’s society. Social media has become the main approach of information acquisition for youth groups nowadays, and the information on social media will have an impact on people’s behavioral decisions. The objective of this study was therefore to investigate the correlation between social media exposure to relevant information about blood donation and the willingness of youths to donate blood.

Methods

We collected data from 455 questionnaires through an online questionnaire and structural equation modeling was constructed for validation. Data were analyzed for reliability, validity, and demographic differences using IBM-SPSS 26.0, and IBM-SPSS-AMOS 26.0 was used for model fit analysis and path analysis.

Results

The results of the study showed that there was a positive correlation between social media exposure to relevant blood donation information and willingness to donate blood (β = 0.262, p < 0.001), altruism (β = 0.203, p < 0.001) and self-efficacy (β = 0.170, p < 0.001). While there was also a positive correlation between attitude toward blood donation and self-efficacy (β = 0.560, p < 0.001), there was no positive correlation between it and willingness to donate blood (β = −0.180, p = 0.786). There was also a positive correlation between altruism and willingness to donate blood (β = 0.150, p < 0.05) and attitude toward blood donation (β = 0.150, p < 0.001). Similarly, there was a positive correlation between self-efficacy and willingness to donate blood (β = 0.371, p < 0.001).

Conclusion

Exposure to more information related to blood donation on social media can increase the willingness of the youth population to donate blood, while exposure to information related to altruism and self-efficacy on social media can also enhance young people’s attitudes toward blood donation, while further strengthening their willingness to donate.
Investing in health preparedness, response and resilience: a genomics costing tool focused on next generation sequencing
Authors: Akande Oluwatosin Wuraola , Afrough Babak , Amante Maria , Carter Lisa , Cunningham Jane , Hull Noah Clayton , Inamdar Leena , Jaguparov Alexandr , Marklewitz Marco , Musul Biran , Norberg Ashley , Pereyaslov Dmitriy I. , Poates Angela Lee , Samaan Gina , Suresh Anita , Uplekar Swapna , Wilhem Aude , Salvi Le Garrec Zwetyenga Joanna , Whistler Toni
Published: May 2024

The world has seen unprecedented gains in the global genomic surveillance capacities for pathogens with pandemic and epidemic potential within the last 4 years. To strengthen and sustain the gains made, WHO is working with countries and partners to implement the Global Genomic Surveillance Strategy for Pathogens with Pandemic and Epidemic Potential 2022–2032. A key technical product developed through these multi-agency collaborative efforts is a genomics costing tool (GCT), as sought by many countries. This tool was developed by five institutions – Association of Public Health Laboratories, FIND, The Global Fund to Fight AIDS, Tuberculosis and Malaria, UK Health Security Agency, and the World Health Organization. These institutions developed the GCT to support financial planning and budgeting for SARS-CoV-2 next-generation sequencing activities, including bioinformatic analysis. The tool costs infrastructure, consumables and reagents, human resources, facility and quality management. It is being used by countries to (1) obtain costs of routine sequencing and bioinformatics activities, (2) optimize available resources, and (3) build an investment case for the scale-up or establishment of sequencing and bioinformatics activities. The tool has been validated and is available in English and Russian at https://www.who.int/publications/i/item/9789240090866. This paper aims to highlight the rationale for developing the tool, describe the process of the collaborative effort in developing the tool, and describe the utility of the tool to countries.
Building a sharable literature collection to advance the science and practice of implementation facilitation
Authors: Ritchie Mona J. , Smith Jeffrey L. , Kim Bo , Woodward Eva N. , Kirchner JoAnn E.
Published: May 2024

Background

Implementation science seeks to produce generalizable knowledge on strategies that promote the adoption and sustained use of evidence-based innovations. Literature reviews on specific implementation strategies can help us understand how they are conceptualized and applied, synthesize findings, and identify knowledge gaps. Although rigorous literature reviews can advance scientific knowledge and facilitate theory development, they are time-consuming and costly to produce. Improving the efficiency of literature review processes and reducing redundancy of effort is especially important for this rapidly developing field. We sought to amass relevant literature on one increasingly used evidence-based strategy, implementation facilitation (IF), as a publicly available resource.

Methods

We conducted a rigorous systematic search of PubMed, CINAHL, and Web of Science citation databases for peer-reviewed, English-language articles with “facilitation” and a combination of other terms published from January 1996 to December 2021. We searched bibliographies of articles published from 1996 to 2015 and identified articles during the full text review that reported on the same study. Two authors screened 3,168 abstracts. After establishing inter-rater reliability, they individually conducted full-text review of 786 relevant articles. A multidisciplinary team of investigators provided recommendations for preparing and disseminating the literature collection.

Findings

The literature collection is comprised of 510 articles. It includes 277 empirical studies of IF and 77 other articles, including conceptual/theoretical articles, literature reviews, debate papers and descriptions of large-scale clinical initiatives. Over half of the articles were published between 2017 and 2021. The collection is publicly available as an Excel file and as an xml file that can be imported into reference management software.

Conclusion

We created a publicly accessible collection of literature about the application of IF to implement evidence-based innovations in healthcare. The comprehensiveness of this collection has the potential to maximize efficiency and minimize redundancy in scientific inquiry about this strategy. Scientists and practitioners can use the collection to more rapidly identify developments in the application of IF and to investigate a wide range of compelling questions on its use within and across different healthcare disciplines/settings, countries, and payer systems. We offer several examples of how this collection has already been used.
Transforming waste management methods: a Dutch Airport’s journey toward a circular economy through baseline measurements and strategic priority setting
Authors: van der Tuin-Rademaker Anne , Tschavgova Elisabeth , van Maaren Christian , Solis Sara , Campisano Saro , van Dam Sonja
Published: May 2024

Airports, the essential hubs of global travel, have to cater for the increasing demands for air travel, with growing passenger numbers and the associated growth in resource consumption. While the aviation sector prioritizes reducing environmental impact in the air, substantial waste is generated at airports. This necessitates a critical examination of waste management practices, especially since a Circular Economy (CE) approach is gaining momentum within the aviation sector. This article introduces the Baseline Circular Airports Method (BCAM), a methodology developed and rigorously tested at Schiphol Amsterdam airport. BCAM systematically analyzes resource streams, considering composition and relevant stakeholders, treatment processes, and environmental impact. By doing so, it establishes strategic prioritization of resource streams for airports to perform focused and effective interventions. BCAM analysis reveals that the highest impact of operational resource streams are Residual, Plastic, Swill, Paper, and International Catering Waste (CAT1), and that corresponding waste management efficiencies can be determined. These outcomes serve as a baseline for ongoing monitoring, offering airports a starting point for strategic planning and assessing progress towards sustainable waste management and CE transitions.
Evidence of Kelvin-Helmholtz and tearing mode instabilities at the magnetopause during space weather events
Authors: Biasiotti Lorenzo , Ivanovski Stavro , Calderone Lorenzo , Jerse Giovanna , Laurenza Monica , Del Moro Dario , Longo Francesco , Plainaki Christina , Marcucci Maria Federica , Milillo Anna , Molinaro Marco , Feruglio Chiara
Published: May 2024

Introduction: Kelvin-Helmholtz (KH) and tearing mode (TM) instabilities are one of the most important mechanisms of solar wind energy, momentum and plasma transport within the magnetosphere.

Methods: To investigate the conditions under which KHTM instabilities occur in the Earth environment it is fundamental to combine simultaneous multipoint in situ measurements and MHD simulations. We analyzed data from the THEMIS and Cluster spacecraft considering two Space Weather (SWE) events starting with an M2.0 flare event (hereafter Case-1) that occurred on 21 June 2015 and the most-intensive flare (X9.3) of solar cycle 24 that occurred on 6 September 2017 (hereafter Case-2).

Results: Our analysis utilized a 2D MHD model for incompressible and viscous flow. The results from Case-1 indicate the presence of KH and TM instabilities, suggesting existence of observed low-amplitude oscillations at the nose of the magnetopause. However, the MHD simulations for Case-2 did not show any evidence of KH vortices, but did reveal the presence of “magnetic island” structures during a low-shear condition. The reconnection rate derived from the observations is compared with the computed one in the presence of developed instabilities inside the Earth’s magnetopause.
Polarization properties of the decameter spikes
Authors: Shevchuk Mykola , Melnik Valentin , Brazhenko Anatolii , Dorovskyy Vladimir , Frantsuzenko Anatolii , Poedts Stefaan , Magdalenic Jasmina
Published: May 2024

An analysis of the observational polarization properties of the decameter spikes is presented in the paper. It is shown that decameter spikes possess high degree of circular polarization with average value of about 60%. In the frames of “leading spot” theory we associated the spikes activity with a certain active region on the solar disk and determined the mode of the emission. Supposing plasma emission mechanism we link and determine coronal plasma and fast electron beam parameters.
The effectiveness of video-based exercise training program for people with intellectual disability: a multicenter study
Authors: Kwan Rachel , Szeto Grace , Ho Ester , Wu Annie , Wong Lavinia , Ho Gilbert , Lau Rufina , Wong Eyckle , Kwok Anthony , Cheung Dorothy
Published: May 2024

Objective

To examine the effectiveness of a specially designed video-based exercise program in promoting physical and balance performance in people with intellectual disability.

Methods

This study was a multicenter controlled trial. Participants with intellectual disability were divided into exercise group and control group by cluster sampling. The participants in the exercise group received 1 h exercise training sessions twice a week for 8 weeks, and the controls continued their usual care without exercise training. The exercises were specially designed to match the physical ability level of the participants classified as high and low, and a third group called “special” was designed for those wheelchair-bound persons with limited mobility. Elements of light-tempo music and animation were introduced in the videos to motivate the participants. Recording the exercises in video format makes it easier for the class instructors and participants to perform the exercises together, and ensure consistency across different exercise groups conducted in different centers. Each participant underwent the pre- and post-intervention assessment including 30-s chair stand repetitions, five-time chair stand duration, 4-m comfortable walk time, standing static balance level, 6-min walk test, and short physical performance battery score. These variables were compared within each group at pre- and post-intervention stages, and they were also compared between the two groups.

Results

A total of 180 participants were enrolled in 16 subcenters, including 160 participants in the exercise group and 20 participants in the control group. After 8 weeks of exercise training, there were significant improvements in their physical performance including 30-s chair stand repetitions and five-time chair stand duration, 4-m comfortable walk time and also 6-min walk test, within the exercise group (all P < 0.05). Approximately 39% of the participants in the exercise group also showed significant improvement in standing static balance level. No significant differences were found when compared with the control group participants who did not have any regular exercise participation.

Conclusion

A specially designed video-based exercise program has demonstrated some positive effects on physical and balance performance after 8 weeks of training among adults with intellectual disability.
A gap approach for preventing stress in complex systems: managing natural hazard induced fiscal risks under a changing climate
Authors: Hochrainer-Stigler Stefan , Mechler Reinhard , Deubelli-Hwang Teresa , Calliari Elisa , Šakić Trogrlić Robert
Published: May 2024

Disasters associated with natural hazards as well as climate change are happening within complex socio-economic systems and desired system states, including sustainable development and resource management, are formulated on the global as well as regional and national levels. However, complex system approaches are yet only rudimentarily incorporated in related applications, and we discuss modeling as well as policy challenges focusing on fiscal risk. As an intermediate step we suggest a gap approach which we relate to fiscal stress levels a complex system may experience due to natural hazard events. We argue that in case of no gaps one can assume a no stress situation and therefore modeling of disruptions including cascading effects is less necessary. However, at the same time we also acknowledge that there is an urgent need to address corresponding challenges with complex system methods. Policy-wise our paper responds to concerns for real-world applications and can provide insights to support current discussions within the UNFCCC and Paris Agreement around both adaptation finance and the new funding arrangements for loss and damage from climate impacts established at COP27.
Enhancing patient comfort in varicose vein treatment through combined lidocaine and ropivacaine tumescent anesthesia
Authors: Li Yubo , Li Tan
Published: May 2024

Objective

To compare the analgesic effects of specific tumescent anesthetic solutions composed of lidocaine, ropivacaine, or a combination of lidocaine and ropivacaine during endovenous radiofrequency ablation for the treatment of great saphenous vein varicosities.

Method

This study included 149 patients with lower limb varicose veins who were admitted to our department between 2019 and 2023. The patients were randomly assigned to three groups: the lidocaine group (Group I), the ropivacaine group (Group II), and the lidocaine + ropivacaine group (Group III). Intraoperative vital signs, intraoperative and postoperative visual analog scale (VAS) pain scores, and long-term treatment outcomes were assessed using the venous clinical severity score (VCSS) based on clinical performance.

Results

There were no significant differences in age, body mass index, operative time, or blood loss among the three groups (P ≥ 0.05). The differences in the mean arterial pressure and heart rate during surgery in Group II were significantly greater than those in Groups I and III (P < 0.05). The intraoperative VAS scores in Group II were higher than those in Groups I and III (P < 0.05) and at 8 and 12 h postoperatively. There were no significant differences in VCSS among the groups (P ≥ 0.05).

Conclusion

The use of a tumescent anesthetic solution composed of lidocaine and ropivacaine significantly improved patient comfort during the perioperative period without affecting surgical outcomes. This formulation can be considered safe and reliable for preparing tumescent anesthesia solutions.
Current and future applications of artificial intelligence in surgery: implications for clinical practice and research
Authors: Morris Miranda X. , Fiocco Davide , Caneva Tommaso , Yiapanis Paris , Orgill Dennis P.
Published: May 2024

Surgeons are skilled at making complex decisions over invasive procedures that can save lives and alleviate pain and avoid complications in patients. The knowledge to make these decisions is accumulated over years of schooling and practice. Their experience is in turn shared with others, also via peer-reviewed articles, which get published in larger and larger amounts every year. In this work, we review the literature related to the use of Artificial Intelligence (AI) in surgery. We focus on what is currently available and what is likely to come in the near future in both clinical care and research. We show that AI has the potential to be a key tool to elevate the effectiveness of training and decision-making in surgery and the discovery of relevant and valid scientific knowledge in the surgical domain. We also address concerns about AI technology, including the inability for users to interpret algorithms as well as incorrect predictions. A better understanding of AI will allow surgeons to use new tools wisely for the benefit of their patients.
Biomechanical evaluation of a fixation technique with a modified hemicerclage for tibial tuberosity transposition: an ex vivo cadaveric study
Authors: Natsios Pavlos , Capaul Rahel , Kopf Norbert , Pozzi Antonio , Tinga Selena , Park Brian
Published: May 2024

Objectives

(1) To determine stiffness, load at failure, and mode of failure of a novel fixation method with a tension modified-hemicerclage (MH) for tibial tuberosity transposition, and (2) to compare the biomechanical properties of this novel fixation technique to 2 pins (2Pins) and 2 pins and tension band wire fixation (2Pins + TBW).

Study design

Thirty cadaveric stifles from dogs between 5.2 and 13.1 kg were assigned to 3 treatment groups: Group 1: fixation technique with MH; Group 2: 2Pins; Group 3: 2Pins + TBW. Biomechanical testing was performed with the tibia positioned at an angle of 135° relative to vertical position. Tensile force was applied to the patellar ligament until catastrophic failure was observed. The mode of failure, the load at failure, and the stiffness were compared among treatment groups.

Results

The mean stiffness of the novel fixation (38.1 N/mm ± 7.1) and the 2Pins + TBW (40.2 N/mm ± 9.3) were greater than the 2Pins (26.7 N/mm ± 6.7). There was no significant difference between the novel fixation technique and 2Pins + TBW in stiffness and maximum load to failure. The 2Pins (284.3 N ± 70.5) failed at a significantly lower load than the tension modified-hemicerclage (555.7 N ± 225.9 N) and 2Pins + TBW (715.3 N ± 339.8 N).

Conclusion

A fixation technique using a modified hemicerclage had the same strength and stiffness as the 2Pins + TBW and was stronger and stiffer than the 2 Pins technique in a cadaveric model.
Trends in enrollment, retention, and graduation of United States veterinary technicians/nurses schools
Authors: Kogan Lori R. , Jensen Wayne A.
Published: May 2024

Objective

There is a significant shortage of veterinary technicians. To help address this issue, there has been a call to increase the capacity of United States VT/N educational programs. Yet, the current challenges within the field may be negatively impacting the number of people deciding to pursue VT/N certification. To assess this possibility, this study was designed to explore the enrollment, retention, and graduation trends within United States VT/N educational programs. Explore the trends between 2018 and 2022 in enrollment, retention, and graduation of veterinary technicians/nurses (VT/N) at educational programs located in the United States.

Sample

Educators and administrators working in United States VT/N educational programs.

Procedures

An electronic survey distributed via an anonymous link within emails sent from the Association of Veterinary Technician Educators.

Results

A total of 82 responses from educators and administrators working in United States VT/N educational programs were received. Forty-three percent of participants indicated a decrease in student enrollment in the last 5 years. The factors seen to have the largest significant impact were “More potential students not convinced being credentialed will lead to a difference in job duties when compared to non-credentialed work,” “More potential students who do not think being credentialed will lead to a substantial increase in pay when compared to non-credentialed work” and “More potential students not willing/able to invest the time needed to become credentialed.” A total of 60% reported an increase in retention efforts within the last 5 years. The services most commonly reported as increasing included mental health support and academic mentoring.

Conclusions and clinical relevance

This study suggests that an increased number of potential VT/N students are deciding that being credentialed is not worth the time or money. While additional resources directed toward recruitment and retention are needed within VT/N educational programs, without systematic changes within the field, it is likely that there will be a continued decline in the number of interested applicants.
Social Representativeness and Intervention Adherence—A Systematic Review of Clinical Physical Activity Trials in Breast Cancer Patients
Authors: Stalsberg Ragna , Darvik Monica Dahle
Published: May 2024

Objectives

Representativeness in physical activity randomised controlled trials (RCT) in breast cancer patients is essential to analyses of feasibility and validity considering privileged- social groups. A step-by-step exclusion of less privileged groups through the trial process could reinforce health inequality. This study aimed at examining representativeness in breast cancer (BC) physical activity trials, investigate associations between socio-economic status (SES) and intervention adherence, and explore associations between representativeness and the relationship between SES and intervention adherence.

Methods

Systematic, computerised searches were performed in PubMed, CINAHL, AMED, EMBASE and PsycINFO. Additional citation-based searches retrieved 37 articles. Distributions of education level, ethnicity, and marital status in study samples were compared to national populations data to estimate representativeness in less privileged groups.

Results

A preponderance of studies favoured educated, married and white patients. Only six studies reported SES-adherence associations, hampering conclusions on this relationship and possible associations between representativeness and an SES-adherence relationship.

Conclusion

Less educated, unmarried and non-white individuals may be underrepresented in BC physical activity RCTs, while SES-adherence associations in such trials are inconclusive. Unintentional social misrepresentations may indicate that disguised inequity warrants revived attention.
HUNCHEST projects—advancing low-dose CT lung cancer screening in Hungary
Authors: Kerpel-Fronius Anna , Bogos Krisztina
Published: May 2024

Lung cancer, the leading cause of malignancy-related deaths worldwide, demands proactive measures to mitigate its impact. Low-dose computer tomography (LDCT) has emerged as a promising tool for secondary prevention through lung cancer screening (LCS). The HUNCHEST study, inspired by the success of international trials, including the National Lung Cancer Screening Trial and the Dutch NELSON study, embarked on the first LDCT-based LCS program in Hungary. The initiative assessed the screening efficiency, incorporating lung function tests and exploring the interplay between lung cancer and chronic obstructive pulmonary disease (COPD). Building upon this foundation, an implementation trial involving 18 Hungarian centers supported by the Ministry of Human Capacities demonstrated the feasibility of LCS within a multicentric framework. These centers, equipped with radiology capabilities, collaborated with multidisciplinary oncology teams, ensuring optimal patient pathways. However, a critical challenge remained the patient recruitment. To address this, the HUNCHEST 3 project, initiated in 2023, seeks to engage general practitioners (GPs) to reach out to eligible patients within a municipality collective of 60 thousand inhabitants. The project’s ultimate success is contingent upon the willingness of eligible individuals to undergo LDCT scans. In conclusion, the HUNCHEST program represents a crucial step in advancing lung cancer screening in Hungary. With a focus on efficiency, multidisciplinary collaboration, and innovative patient recruitment strategies, it endeavors to contribute to the reduction of lung cancer mortality and serve as a blueprint for potential nationwide LCS programs.
Pitfalls in Valganciclovir Prophylaxis Dose Adjustment Based on Renal Function in Kidney Transplant Recipients
Authors: Hammer Nathalie , Hoessly Linard , Haidar Fadi , Hirzel Cédric , de Seigneux Sophie , van Delden Christian , Vogt Bruno , Sidler Daniel , Neofytos Dionysios
Published: May 2024

Valganciclovir (VGC) is administered as prophylaxis to kidney transplant recipients (KTR) CMV donor (D)+/recipient (R)− and CMV R+ after thymoglobulin-induction (R+/TG). Although VGC dose adjustments based on renal function are recommended, there is paucity of real-life data on VGC dosing and associations with clinical outcomes. This is a retrospective Swiss Transplant Cohort Study-embedded observational study, including all adult D+/R− and R+/TG KTR between 2010 and 2020, who received prophylaxis with VGC. The primary objective was to describe the proportion of inappropriately (under- or over-) dosed VGC week-entries. Secondary objectives included breakthrough clinically significant CMV infection (csCMVi) and potential associations between breakthrough-csCMVi and cytopenias with VGC dosing. Among 178 KTR, 131 (73.6%) patients had ≥2 week-entries for the longitudinal data of interest and were included in the outcome analysis, with 1,032 VGC dose week-entries. Overall, 460/1,032 (44.6%) were appropriately dosed, while 234/1,032 (22.7%) and 338/1,032 (32.8%) were under- and over-dosed, respectively. Nineteen (14.5%) patients had a breakthrough-csCMVi, without any associations identified with VCG dosing (p = 0.44). Unlike other cytopenias, a significant association between VGC overdosing and lymphopenia (OR 5.27, 95% CI 1.71–16.22, p = 0.004) was shown. VGC prophylaxis in KTR is frequently inappropriately dosed, albeit without meaningful clinical associations, neither in terms of efficacy nor safety.
Anomaly Detection in Blockchain Networks Using Unsupervised Learning: A Survey
Authors: Cholevas Christos , Angeli Eftychia , Sereti Zacharoula , Mavrikos Emmanouil , Tsekouras George E.
Published: May 2024

In decentralized systems, the quest for heightened security and integrity within blockchain networks becomes an issue. This survey investigates anomaly detection techniques in blockchain ecosystems through the lens of unsupervised learning, delving into the intricacies and going through the complex tapestry of abnormal behaviors by examining avant-garde algorithms to discern deviations from normal patterns. By seamlessly blending technological acumen with a discerning gaze, this survey offers a perspective on the symbiotic relationship between unsupervised learning and anomaly detection by reviewing this problem with a categorization of algorithms that are applied to a variety of problems in this field. We propose that the use of unsupervised algorithms in blockchain anomaly detection should be viewed not only as an implementation procedure but also as an integration procedure, where the merits of these algorithms can effectively be combined in ways determined by the problem at hand. In that sense, the main contribution of this paper is a thorough study of the interplay between various unsupervised learning algorithms and how this can be used in facing malicious activities and behaviors within public and private blockchain networks. The result is the definition of three categories, the characteristics of which are recognized in terms of the way the respective integration takes place. When implementing unsupervised learning, the structure of the data plays a pivotal role. Therefore, this paper also provides an in-depth presentation of the data structures commonly used in unsupervised learning-based blockchain anomaly detection. The above analysis is encircled by a presentation of the typical anomalies that have occurred so far along with a description of the general machine learning frameworks developed to deal with them. Finally, the paper spotlights challenges and directions that can serve as a comprehensive compendium for future research efforts.
From Residue to Resource: A Physicochemical and Microbiological Analysis of Soil Microbial Communities through Film Mulch-Enhanced Rice Straw Return Strategies
Authors: Wang Xinyue , Huang Jie , Yang Lili , Li Yuanhuan , Xia Bing , Li Hailin , Deng Xiaohua
Published: May 2024

Promoting rice straw in situ return is an important strategy for improving soil quality. From 2018 to 2021, we investigated the effects of rice straw return with microbial agents and film covering technology on soil physical and chemical properties at different layer depths, as well as the soil microbial community structure, in Hunan, southern China. This study was designed to evaluate the effects of microbial agents (T1), film mulch covering (T2), and the application of microbial agents combined with film mulch (T3) on the soil physicochemical properties and microbial community after rice straw in situ return. The results show that, after three years of continuous treatment, T3 significantly increased the soil temperature by 17.76–22.97%, T2 significantly increased the water content by 34.27–46.23%, and T1 and T3 significantly increased the soil pH. The addition of microbial agents combined with film mulch resulted in a notable increase in both the number of OTUs and the Chao1 index of soil microorganisms. Additionally, the model of promoting rice straw in situ return (the application of a microbial agent combined with film mulch) was shown to promote the growth of beneficial soil microorganisms. RDA was used for the investigation, and the findings showed that soil microorganisms were significantly influenced by the TOC content, pH, and water content. These findings provide evidence of an effective method for accelerating the decomposition of late rice straw and guiding soil improvement in tobacco–rice rotation regions.