bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuritin Alleviates Diabetic Retinopathy by Regulating Endoplasmic
Reticulum Stress in Rats
Authors: Wen Shu , Hu Meng , Chen Changzheng , Li Zhen , Liu Guoli
Published: January 2024

Background:

Neuritin, a small-molecule neurotrophic factor, maintains neuronal cell
activity, inhibits apoptosis, promotes process growth, and regulates neural progenitor cell differentiation,
migration, and synaptic maturation. Neuritin helps retinal ganglion cells (RGCs) survive
optic nerve injury in rats and regenerate axons. However, the role of Neuritin in Diabetic retinopathy
(DR) is unclear.

Objective:

This study is intended to investigate the effect and mechanism of Neuritin in DR. For
this purpose, we established DR rat models and injected Neuritin into them. This study provides a
potential treatment for diabetic retinopathy.

Methods:

The rat model of DR was established by streptozotocin (STZ) injection, and the effect
of Neuritin on DR was detected by intravitreal injection. Histological analysis was performed by
H&E and TUNEL methods. The mRNA and protein expressions of endoplasmic reticulum stress
(ERS) pathway-related transcription factors were detected by qRT-PCR and western blot. The
blood-retinal barrier (BRB) function was assessed using the patch-clamp technique and Evans blue
leakage assay.

Results:

Neuritin significantly improved the retinal structure, restrained the apoptosis of retinal
cells, and protected the normal function of BRB in DR model rats. Mechanistically, Neuritin may
function by inhibiting the expression of GRP78, ASK1, Caspase-12, VEGF, and so on.

Conclusion:

Our results indicate that Neuritin alleviates retinal damage in DR rats via the inactive
endoplasmic reticulum pathway. Our study provides a potential treatment for DR.
Role of Ubiquitin-specific Proteases in Hepatocellular Carcinoma
Pathogenesis
Authors: Zhang Xinwen , Jin Jiamin , Cong Jiacheng , Chen Siqi , Wang Ting , Gao Bin , Huang Guanlin , Huang Zhiqiang , Zhang Juzheng , Wang Zhenran , Yang Jinfeng
Published: January 2024

Signaling pathways in hepatocellular carcinoma are primarily mediated by the phosphorylation
and ubiquitination of post-translational proteins. In mammalian cells, ubiquitin-specific
proteases (USPs) account for the majority of protein deubiquitination activities. In addition to transcriptional
and post-translational regulation, ubiquitination plays an important role in the regulation
of key proteins. There is a possibility that altered biological processes may lead to serious human
diseases, including cancer. Recent studies have revealed the role of USPs in hepatocellular
carcinoma tumorigenesis. The purpose of this review is to summarize the involvement of this
class of enzymes in the regulation of cell signaling in hepatocellular carcinoma and the therapeutic
development of inhibitors that target USPs, which may lead to novel therapies to treat hepatocellular
carcinoma.
Deteriorating Pulmonary Functions in Patients with Rheumatoid
Arthritis- A Pilot Study from South India
Authors: Shanmugavaradharajan Vijayabaskaran , NT Rajesh , R Divya , Vasudevan Damodaran
Published: January 2024

Background and Objective:

Pulmonary involvement is a common extra-articular manifestation
of rheumatoid arthritis (RA). The present study attempts to highlight the extent of involvement
by assessing lung function using pulmonary function tests (PFTs) in patients with RA.

Methods:

This pilot study involved 30 patients with RA and an equal number of age- and sexmatched
healthy controls. All the study participants were subjected to spirometry and in RA patients,
the test was repeated after 30 minutes of administering 400 mcg of salbutamol. PFT values
of the controls and the pre and post-values of cases like forced vital capacity (FVC), forced expiratory
volume in the first second (FEV1), Percentage of forced expiratory volume in the first second
(FEV1%), forced expiratory flow at 25% to 75% of the lung volume (FEF25-75%) and peak expiratory
flow rate (PEFR) were recorded. Independent sample t-test or Mann-Whitney U test were
used for comparisons. The pre- and post-values of PFT were compared using paired t-test,
Welsch’s test, or Wilcoxon tests. (p ≤ 0.05 implied statistical significance).

Results:

PFT variables were significantly lower among patients with RA compared with controls
(p<0.05). A significant negative correlation of FEF25%-75% and PEFR with BMI in obese patients
(BMI >23) and FVC, FEV1, and PEFR significantly lower in post-menopausal women (p <
0.05) was seen.

Conclusion:

Based on the pilot study findings, patients in south India with RA could manifest decreased
pulmonary functions. Obese patients and post-menopausal females with RA could be at a
higher risk, and the administration of nebulized salbutamol could improve pulmonary functions.
Acute Pancreatitis Obstructed by a “Stone” as the First Manifestation of
Eosinophilic Gastroenteritis in AIDS: A Case Report
Authors: Zhang Fulong , Xu Jing , Zhu Yuandong , Chen Shurong , Shi Yan , Zhan Zongyuan , Zhou Jingwei , Jiang Yuhong , Wang Hai
Published: January 2024

Background::

Acquired immune deficiency syndrome (AIDS) associated with eosinophilic gastroenteritis is rare. We report a case of duodenal “stone” inducing
acute pancreatitis with eosinophilic gastroduodenitis in an AIDS patient.

Case Summary::

A 73-year-old female AIDS patient came to the hospital with recurrent abdominal pain for 20 days. Computed tomography (CT) showed
pancreatitis with exudation and a high-density shadow under the gastric antrum. Gastroscopy showed that the descending part of the duodenum
was blocked by a “stone”. The mucosa of the duodenum was rough, and a red polyp was found on the gastric body. The pathology result was
chronic inflammation with eosinophilic granulocytes in the duodenal mucosa and gastric body polyp.

Conclusion::

When AIDS patients suffer acute pancreatitis, the possibility of eosinophilic gastroenteritis needs to be considered to enable the patient to accept
timely treatment.
Quantitative Analysis of the Impact of Different Delivery Modes on Cervical
Elasticity Based on Real-time Shear Wave Imaging Technology and Artificial
Intelligence
Authors: Song Xue , Liu Cun , Chen Shuai
Published: January 2024

Background::

Real-time shear wave elastography (SWE) has emerged as a useful imaging modality for detecting the lesion location of various diseases,
including cervical diseases.

Objectives::

In this paper, the SWE was used to quantitatively determine the tissue hardness of the internal and external orifice of cervix (IOC &amp; EOC), and to relatively objectively analyze the impact of different production methods on the hardness of the cervical tissue.

Methods::

A total of 48 patients were selected, and they were divided into three groups according to different production methods: control group (16 cases),
cesarean section group (16 cases), and spontaneous delivery group (16 cases). Artificial intelligence has also been incorporated into this work. A
deep flexible neural tree model and a new set of FNT models were proposed to assist in classifying cervical physical data in different states. The
physical data was extracted as the features, and the different states were considered as category labels.

Results::

There was no statistically significant difference in the elasticity of the IOC and the EOC between the groups; the difference in the elasticity of the IOC and the EOC of each group was statistically significant. The classification results kept correspondence with statistical analysis results. The hardness of the EOC is generally lower than that of the IOC, and no significant difference occurred in the hardness of the IOC and the EOC between three groups.

Conclusion::

There is no significant difference in the hardness of cervical elasticity between different delivery modes.
Integrated Bioinformatics Analysis and Target Drug Prediction of Inflammatory Bowel Disease Co-existent Diabetes Mellitus
Authors: Yang Lili , Wang Ning , Wang Yutong , Li Wen , Kong Ziyang , Zhang Bin , Bian Yaoyao
Published: January 2024

Introduction:

Inflammatory bowel disease (IBD) has become one of the public problems
worldwide and its incidence rate is increasing year by year. Its concomitant disease i.e.
diabetes mellitus (DM) has attracted more and more attention due to DM altering the progression
of IBD and leading to long periods of intermittent recurrence and deterioration. The common
mechanism and potential target drug of IBD with comorbid chronic conditions of DM were
explored.

Methods:

Gene expression profile data were downloaded from the Gene Expression Omnibus
(GEO) public database. The differentially expressed genes (DEGs) were identified by R software.
GO annotation and pathway enrichment were performed, a protein-protein interaction
(PPI) network was constructed, associated lncRNAs were predicted and drug prediction targeting
key genes was made. Additionally, the regulatory network among core genes, associated
pathways, and predicted lncRNA in IBD with coexistent DM were visualized.

Results:

We identified the critical gene MMP3 with lncRNA CDKN2BAS involved in the
PPAR pathway, which uncovered the underlying regulatory mechanism of IBD with coexistent
DM. We also predicted the potential therapeutic compound ZINC05905909 acting on MMP3.

Conclusion:

Our findings revealed the regulatory mechanism chain of critical gene MMP3,
lncRNA CDKN2BAS, and PPAR pathway and provided potential therapeutic compound
ZINC05905909 for drug therapy to treat comorbid IBD DM.
Evaluation of Phytochemicals, Antioxidants, and Antidiabetic Activity of
Nitophyllum marginale by Using Analytical Approaches
Authors: Malhotra Rohit , Cojandaraj Louis
Published: January 2024

Background:

Nitophyllum marginale holds potential for medical applications due to its
bioactive compounds, making it promising for developing new therapeutic interventions. Our study
aims to evaluate the bioactivity of Nitophyllum marginale extracts obtained using methanol and
chloroform solvents. We focus on analyzing the phytochemical profile, antioxidant activity, and antidiabetic
potential of seaweed extract in this study. By examining the medicinal properties
of Nitophyllum marginale, we aim to explore the therapeutic bioactivity potentiality and its prime
role in improvising and searching for potential alternatives for seizing Diabetes mellitus.

Materials and Methods:

The antioxidant activity of Nitophyllum marginale was evaluated using
ABTS, DPPH, nitric oxide, lipid peroxidation, and hydrogen peroxide assays. Additionally, alphaglucosidase
inhibition tests were conducted to evaluate the potential as an antidiabetic agent.

Results:

The study revealed that extracts from Nitophyllum marginale contain antioxidants that protect
cells from oxidative stress. These extracts also contain bioactive compounds like alkaloids, flavonoids,
phenols, saponins, and carbohydrates. These compounds work together to provide antioxidant
benefits. Additionally, the extracts showed activity against alpha-glucosidase, which is vital for
managing blood sugar levels.

Conclusion::

These results emphasize the existence of bioactive metabolites exhibiting phytochemicals,
antioxidants, and antidiabetic activities obtained from the extract using chloroform and methanol
solvents. These findings suggest the potential of Nitophyllum marginale extracts as a natural
reservoir of antioxidants and antidiabetic agents.
Production of Nattokinase from Bacillus amyloliquefaciens MRS18: A
Bacterial Strain Isolated from Fermented Beans
Authors: Coutinho Simran B. , Shirodkar Rutuja R. , Kanjirakkandy Anju , Arulmozhi Vijayaganapathi , Vaithilingam Mohanasrinivasan , Chandrasekaran Subathra D.
Published: January 2024

Background::

Nattokinase (NK) is a naturally occurring fibrinolytic protease enzyme
obtained from the traditional Japanese food called Natto and has several uses in the pharmaceutical
and medical industries. Nowadays, the most often used thrombolytic agent in the clinical
field is NK, in part because it is less expensive than other thrombolytic medicines.

Objective::

The objective of this study is to investigate the screening, isolation and characterization
of the NK enzyme-producing Bacillus strain from fermented Soya beans.

Methods::

The sample of fermented soya beans were tested for the presence of fibrinolytic protease-
producing bacteria, followed by the screening, extraction, characterization and clot lysis assays.

Results::

A total of three isolates were screened for caseinolytic activities by casein hydrolysis
assay. Out of those isolates, MRS18 was found to be potent in producing the enzyme proteinase.
To determine the taxonomy and phylogeny of these isolates, biochemical and molecular characterization
has been carried out. Bacillus amyloliquefaciens MRS18 has been found with the highest
caseinolytic activity. The clot lysing ability of the potent strain Bacillus amyloliquefaciens
was found to be 61.7% after 120 min, and on further purification, by ammonium sulphate precipitation
method, the lysis percentage was found to be 656% after 120 min.

Conclusion::

From the results of the present study, we concluded that Bacillus amyloliquefaciens
isolated from the fermented soya beans produced an NK enzyme that exhibits immense
potential to lyse blood clots.
Improved Thermal Performance and Distillate of Conventional Solar Still
via Copper Plate, Phase Change Material and CuO Nanoparticles
Authors: Kumaravel Subramanian , Nagaraj Meenakshi Sunadaram , Bharathiraja Govindarajan
Published: January 2024

Background::

The world is currently facing a growing concern regarding freshwater scarcity,
which has arisen as a result of a complex interplay of various factors. Renewable energy-powered
water desalination is a feasible solution to address freshwater scarcity.

Methods::

This patent study presents a comprehensive investigation of the performance of a conventional
solar still (CSS) and its modified versions, such as a still with copper plates, a still with PCM
and a still with PCM and 3 wt% CuO nanoparticles blend. The experiments were carried out concurrently
under identical circumstances for the CSS and the proposed stills. Prior to usage, the CuO nanoparticles
and their blend with PCM were characterized through various analyses

Results::

The investigation showcased the copper plate attached solar still with 3 wt% CuO nanoparticles
blended with PCM significantly improved the distillate production, achieving approximately 6.85
kg/m2/day. This represents an increment of approximately 23.42% compared to the still with copper
plate and PCM and 69.14% related to the CSS.

Conclusion::

Moreover, the solar still with 3 wt% CuO nanoparticles blended with PCM demonstrated
a thermal efficiency of 74.23% and an exergy efficiency of 9.75%. The production cost of distillate
for all four stills remained at $0.03 per kg. These findings highlight the effectiveness of the proposed
copper plate attached solar still with 3 wt% CuO nanoparticles blended with PCM as a viable method
for producing potable water.
ETSI ITS: A Comprehensive Overview of the Architecture, Challenges
and Issues
Authors: Lone Faisal Rasheed , Verma Harsh Kumar , Sharma Krishna Pal
Published: January 2024

Intelligent Transportation Systems (ITS) have attracted the attention of developing
nations because of their potential to enhance mobility and road safety, two issues that have become
increasingly pressing in recent years. Information and Communication Technology (ICT)
has accentuated every industry, and the automobile industry is no exception, allowing vehicles
to communicate among themselves and the surrounding infrastructure for information exchange
using Vehicle-to-Everything (V2X) communication. Vehicle-to-vehicle (V2V), vehicle-
to-infrastructure (V2I), vehicle-to-pedestrian (V2P), and vehicle-to-cloud (V2C) connections
are made possible through the use of state-of-the-art networking technology. With EVehicles
at the forefront, the vision of an ITS expands further. ITS is anticipated to offer wireless
network-based services including vehicle occupant entertainment, traffic flow optimization,
and accident prevention. Most nations have been trying to standardize the ITS architecture,
and the European Union (EU) has been at the forefront by developing and standardizing
the ETSI (European Telecommunications Standards Institute) architecture. As the most mature
ITS architecture, this paper thoroughly explains the ETSI architecture in a single document for
both the researcher's and newcomers' ease. Additionally, the challenges and issues pertinent to
adopting and implementing the ITS ecosystem have also been discussed in detail.
The Effect of Preoperative Gabapentin on the Duration of Spinal Anaesthesia in Patients Undergoing Lower Limb Surgery: A Randomized Controlled Clinical Trial
Authors: Sobhy Amr , Saleh Lobna A. , Ali Mohamed Mourad , Refaat Sameh Ahmed
Published: January 2024

Background:

In the present study, we aim to examine oral gabapentin efficacy as an adjuvant to spinal anesthesia.

Methods:

This prospective, clinical, randomized trial included subjects between 20 and 60 years undergoing lower limb surgeries categorized into two cohorts. Group (G) received gabapentin (900 mg) in two divided doses prior to spinal anesthesia; (300 mg 10 hrs prior to spinal anesthesia induction as well as 600 mg 2 hrs before spinal anesthesia). In contrast, the control Group (C) received only spinal anesthesia. The onset, as well as the duration of spinal anesthesia, were the primary outcome, while the secondary outcome was the postoperative nalbuphine consumed.

Results:

A total of 60 cases were evenly categorized into two cohorts. Both groups demonstrated no differences regarding motor and sensory block onset and duration. The group receiving preoperative gabapentin had a significant decrease in postoperative nalbuphine consumption with a mean of 20.8±9.4 mg compared to the control group, which showed an increased consumption of 28.9±10.4 mg with a p-value of 0.006. Further analysis of the Visual Analog Score (VAS) in both groups revealed that the decrease in total nalbuphine consumption was found at (8 and 10 hrs) postoperatively, with p values of 0.016 and 0009, respectively.

Conclusion:

Gabapentin administration (900 mg) within 10 hrs of surgery in two subdivided doses prior to spinal anesthesia had no effect on onset and duration of spinal anesthesia but had a delayed beneficial postoperative analgesic effect.

Clinical Trial Registration Number:

This trial was registered at ClinicalTrials.gov (NCT05659810, URL: https://clinicaltrials.gov/ct2/show/NCT05659810in 21st December 2022.
Analgosedation Management in the Intensive Care Unit: A Narrative Systematic Review
Authors: Lia Elena , Pucci Valentina , Raccagna Cecilia , Sebastiani Stefano , Dekel Boaz Gedaliahu Samolsky
Published: January 2024

Background:

Intensive care unit (ICU) patients' pain and sedation management is a significant nursing challenge. Sedatives and muscle relaxants administration has been long used for improving patients' comfort and tolerance to mechanical ventilation. This practice led to an increase in adverse ICU outcomes in terms of health status, hospitalization stay, infections, and mortality. The use of appropriate ICU pain and sedation assessment tools is limited.

Methods:

We conducted a narrative literature systematic review (from 2010 to 2022) whose primary aims were to analyze the analgosedation definition and identify ICU patients’ pain, agitation, and sedation assessment tools; secondary aims were to explore analgesia and sedation pharmacological and non-pharmacological treatments and nurses’ perceptions and attitudes regarding analgosedation issues.

Results:

We retrieved 45 eligible articles. Analgosedation foresees early pain management - using pharmacological and non-pharmacological approaches and then, if necessary, implementing adequate sedation. Recommended assessment tools are the Behavioral Pain Scale (BPS) and the Critical Care Observational Tool (CPOT) for pain assessment, the Richmond Agitation Sedation Scale (RASS), and the Sedation Agitation Scale (SAS) for sedation assessment. Guidelines and specific protocols recommend both pharmacological and non-pharmacological approaches. Health professionals report mainly barriers (lack of adherence to guidelines and protocols, workload, reduced awareness, and own perceptions) to analgosedation correct application. The implementation of ICU analgosedation strategies requires continuous health professionals’ commitment and collaboration and valid assessment tools use.

Conclusion:

ICU analgosedation management (pain control first, and then sedation if necessary) is limited due to health professionals' knowledge gaps, inappropriate use of assessment tools, guidelines, and specific protocols. Recommended assessment tools are the BPS and CPOT for pain assessment and the RASS and SAS for sedation assessment. Interventions to improve ICU analgosedation awareness and practice include training events, the use and consultation of literature guidelines, and the use of validated assessment tools.
Supervised Rank Aggregation (SRA): A Novel Rank Aggregation
Approach for Ensemble-based Feature Selection
Authors: Jain Rahi , Xu Wei
Published: January 2024

Background:

Feature selection (FS) is critical for high dimensional data analysis.
Ensemble based feature selection (EFS) is a commonly used approach to develop FS techniques. Rank aggregation (RA) is an essential step in EFS where results from multiple models
are pooled to estimate feature importance. However, the literature primarily relies on static
rule-based methods to perform this step which may not always provide an optimal feature set.
The objective of this study is to improve the EFS performance using dynamic learning in RA
step.

Method:

This study proposes a novel Supervised Rank Aggregation (SRA) approach to allow
RA step to dynamically learn and adapt the model aggregation rules to obtain feature importance.Method: This study proposes a novel Supervised Rank Aggregation (SRA) approach to allow
RA step to dynamically learn and adapt the model aggregation rules to obtain feature importance.

Results:

We evaluate the performance of the algorithm using simulation studies and implement
it into real research studies, and compare its performance with various existing RA methods.
The proposed SRA method provides better or at par performance in terms of feature selection
and predictive performance of the model compared to existing methods.

Conclusion:

SRA method provides an alternative to the existing approaches of RA for EFS.
While the current study is limited to the continuous cross-sectional outcome, other endpoints
such as longitudinal, categorical, and time-to-event data could also be used.
Laser Cladding for Restoring and Increasing the Durability of Railway Wheels
Authors: Zhumekenova Z.Z.
Published: January 2024

The book analyses the design features of railway wheel pairs and investigates methods for increasing the durability of these wheels. Laser cladding of the surface of the wheels can successfully be employed for increasing their durability.
O exotismo na literatura orientalista portuguesa
Authors: Caiyan Zhong
Published: January 2024

This paper results from an investigation with the theme of Chinese images in Portuguese literary Orientalism. The study will show the situation of Portugal in the period, which reveals the double axis (Western and national) of the critique of Orientalism Portuguese. We will look for the oriental representations in the works of the authors of the Generation of 1870, whose works renew Portuguese literature with orientalist tendencies. Next, we will develop a reading of the images of Macau in authors of the territory, which configure the symbolism in Portuguese. In addition, oriental exoticism is highlighted in Chinese female images in the works of Wenceslau de Moraes (1854-1929) and Maria Ondina Braga (1932-2003). The analysis of the female images will show the observation of the Portuguese authors about the Eastern Other. The three facets of reading will facilitate the understanding of the double axis of criticism and the perception of the construction of the Lusitanian identity with the literary imaginary of the exotic East.
A comprehensive review of Yoga's impact on Immunomodulatory Functions and Microbiome in Obesity
Authors: B S Anantha Krishna , K. Krishna Sharma
Published: January 2024

The issue of food security is often viewed through the lens of scarcity, but an equally critical concern is the global rise of obesity resulting from excessive energy intake and insufficient expenditure. Affluent societies, driven by food trends favoring energy-dense, nutrient-poor diets coupled with sedentary lifestyles, grapple with the burgeoning problem of overweight and obesity. India, too, faces a surge in obesity, contributing to lifestyle-related and metabolic disorders. Multiple factors, including diet, genetics, environment, and notably, a lack of physical activity, contribute to this health crisis. Obesity, marked by low-grade inflammation, significantly impacts immune function. Research indicates alterations in the intestinal immune system, fostering a pro-inflammatory environment linked to metabolic disorders associated with obesity. True health encompasses physical, mental, and social well-being, transcending the mere absence of disease. Lifestyle elements like environment, sleep, diet, and exercise play pivotal roles in maintaining good health. Yoga, emerging as a prominent Complementary and Alternative Medicine (CAM) therapy, holds promise for enhancing physiological and psychological health. In addressing obesity and modulating immune functions, non-invasive, non-pharmaceutical interventions, like yoga, offer viable solutions. Studies attest to yoga's positive impact on inflammatory markers in the obese, yet a comprehensive understanding of its effects on immunomodulation and the gut microbiome in obesity within the context of Indian and Yogic systems warrants deeper exploration. Incorporating such holistic approaches into daily routines could provide effective strategies for combating obesity and promoting overall well-being.
A review on Ayurveda dietetics for Amlapitta (Gastroesophageal Reflux Disease) by different Ayurveda classical texts
Authors: Padmaveer PS  , Sandeep S Sagare
Published: January 2024

Amlapitta could be a commonly experienced illness of Annavaha Srotasa (gastrointestinal system) depicted in different classical Ayurvedic writings that affects people of all ages, genders, regions, and climates. The 21st century is regarded as the modern era due to which bygone eating habits and life style is totally changed. Indulgence of food articles such as over processed, under processed and incompatible dietary preparations are the root cause of most of the non-communicable disorders now a days. Ritucharya (a seasonal regime) and Dinacharya (a diurnal regime) were some of the dos and don'ts mentioned by Acharyas. In addition to being an integral part of the regimen of good health, the Ayurvedic teachings of Acharyas also included Pathya (healthy) and Apathaya (unhealthy) as a component in the treatment of diseases. This highlights the significance of Pathya (healthy) and Apathya (unhealthy) in Ayurveda.  So, it is the pressing priority to know the Pathyas (wholesome) and Apathyas (unwholesome) of Amlapitta explained by different Acharyas.
A clinical study to evaluate the efficacy of Arishtaka enema in Pre-Operative Bowel Preparation - A Case Series
Authors: Suraj Ravi Anvekar  , Sweta KM
Published: January 2024

Bowel preparation before surgery refers to the removal of bowel contents via mechanical cleansing with oral or rectal measures. The proposed benefits are reduced rate of surgical site infections and easier manipulation of the bowel during surgery. An ideal bowel-cleansing agent should be well tolerated by subjects, easily administered, inexpensive and produce adequate clearance. The most extensively used enema agent is soap but due to its chemical constituents it is known to cause various side effects like nausea, gastric irritation, pain, etc. In Ayurveda, Acharya Sushrutha suggests patients are to be Nivrutta Vega i.e., free from natural urges prior to the surgery. Also, the drug Arishtaka seems to have the Rechaka, natural cleansing, non-allergic and surfactant properties. Considering these qualities, a preliminary attempt was made to study the effect of Arishtaka in bowel preparation. In the current study it has shown effective results and adequate quality of bowel preparation.
A case study on Kitibha Kusta (Psoriasis) with Samshodana Chikitsa
Authors: Akshata  , I. S. Mathapati  , G S Dharmannavar
Published: January 2024

All the skin diseases in Ayurveda have been discussed under the broad heading of “Kustha”. In general Twak Vikaras are mainly affecting due to altered lifestyle, lack of physical exercise, poor hygiene, mental stress and improper food habits. Kitibha Kushta is one of the Kshudra Kushta. Here Tridosha, Rasa, Rakta, Mamsa, Ambu are affected. Kapha-Vata is the Dosha predominant in the Kitibha Kustha and Rakta Dusti is the main cause for all Twak Vikaras. Vamana and Virechana is the Shodhana Karma for Twak Vikara. After Shodhana, Shamana Chikitsa plays major role for Alpadosha Nirharana. This paper highlights a case study of Kitibha Kushta as a Raktavahasrotodusti Vikara treated with the Ayurvedic principles in particular Shodhana Chikitsa.
A survey study on Traditional Food Pattern of Kandhamal and Boudh District (Odisha)
Authors: Abanikanta Sahoo  , Pramod Kumar Mishra  , Brahmananda Sharma  , Avadhesh Shandilya
Published: January 2024

Ayurveda is an ancient science of life science since time immemorial and it was developed more than 3000 years ago. It’s based on the belief that health and wellness depend on a delicate balance between the body, mind, and spirit. Ayurveda, apart from providing various therapeutic measures for diseases, emphasizes maintenance, promotion of health, and prevention of diseases through diet and lifestyle regimens. In Ayurveda food, sleep, and celibacy are considered as the three supports (Traya Upastambha) of life.  Food is the best among things that sustain life and it has been given prime importance for health. No medicine is equivalent to food. It is possible to make a person disease-free and healthy with just a proper diet. Traditional foods are foods and dishes that are passed on from generation to generation on have been consumed for many generations. For growth and development as well as maintain of health, nutritional food is highly required. So that scholar wants to know about what are the traditional food pattern and what is the status of health by taking traditional food pattern.
PENAMBAHAN VIRGIN COCONUT OIL DAN EMULGATOR PADA LULUR BEDDA LOTONG SERTA PENGARUHNYA TERHADAP SIFAT FISIKOKIMIA DAN AKTIVITAS ANTIOKSIDAN
Authors: Zaenal Nurul Insani , Wijana Susinggih , Pranowo Dodyk
Published: January 2024

Bedda Lotong merupakan lulur tradisional dari suku Bugis yang memiliki karakteristik kasar sehingga diperlukan inovasi untuk meningkatkan mutu, baik sifat fisik kimia maupun nutrisi. Salah satu bahan alami yang diduga dapat meningkatkan mutu lulur Bedda Lotong adalah VCO. Lulur Bedda Lotong tidak dapat dikombinasikan langsung dengan VCO, dikarenakan VCO merupakan emulsi minyak yang tidak dapat berdiri sendiri, sehingga diperlukan emulgator sebagai bahan untuk menstabilkan emulsi. Penelitian ini bertujuan untuk memperoleh formulasi Bedda Lotong dengan penambahan konsentrasi VCO dan emulgator yang dapat memperbaiki karakteristik fisik dan meningkatkan nutrisi berupa antioksidan dalam sediaan. Hasil penelitian menunjukkan bahwa ukuran diameter droplet meningkat seiring dengan penambahan konsentrasi VCO sebesar 15,85-34,93 µm. Nilai viskositas mengalami penurunan seiring dengan peningkatan konsentrasi VCO dimana formulasi F6 berbeda nyata dengan formulasi lainnya (p<0,05). Nilai pH menunjukkan adaya perubahan di hari ke-7, namun emulgator Trietanolamin/TEA cenderung stabil. Nilai aktivitas antioksidan (IC50) terbukti mengami penurunan seiring dengan penambahan konsentrasi VCO. Kandungan aktivitas antioksidan terbaik diperoleh pada formulasi F6. Secara umum formulasi terbaik diperoleh pada formulasi F3 dengan penembahan VCO 25% dan emulgator jenis Trietenolamin/TEA.
Impacto de estratégias de aquecimento nos sistemas de construção LSF: avaliação do conforto térmico e desempenho energético
Authors: Almeida R.M.S.F. , Vicente R. , Figueiredo A. , Figueiredo M.
Published: January 2024

A importância de compatibilizar um bom desempenho térmico com uma elevada eficiência energética é um desafio relevante e atual nos edifícios residenciais. Nos países do sul da Europa, o recurso aos sistemas de aquecimento é, muitas vezes, condicionado, por um fenómeno designado por pobreza energética. Neste contexto, o desafio de procurar soluções construtivas sustentáveis, que otimizem o desempenho térmico dos edifícios, é ainda mais premente.

O sistema construtivo em aço enformado a frio, Light Steel Framing (LSF), tem vindo a ocupar uma posição mais relevante no mercado e de forma crescente. No entanto, a utilização destes sistemas é ainda questionada devido à sua fraca inércia térmica. Este estudo pretende contribuir para a compreensão do comportamento térmico e do desempenho energético de edifícios em LSF localizados em climas mediterrâneos. Para apoiar este trabalho, utilizam-se duas células de teste, uma composta por materiais tradicionais (construção em betão armado e alvenaria) e uma segunda composta por construção em aço enformado a frio. Foi comparado o desempenho das duas células de teste no período de inverno, considerando-se diferentes estratégias de aquecimento (contínuo e intermitente), procurando-se assim analisar os hábitos reais de aquecimento da população, neste caso de estudo, portuguesa. A monitorização inclui a medição da temperatura do ar interior e do consumo de energia para aquecimento.

Na sequência deste trabalho, pretende-se contribuir para uma melhor compreensão do desempenho térmico e energético dos edifícios em aço enformado a frio quando comparados com edifícios de construção tradicional, bem como na capacidade destes de proporcionarem um ambiente confortável de forma mais económica e mais sustentável.
Pandemic-Led Imperative Shift To Digital Transformation – A Critical Analysis
Authors: Tanushree Chattaraj
Published: January 2024

The coronavirus pandemic is essentially reshaping global businesses. At the onset of the pandemic andthrough its consecutive lockdown phases customers dramatically shifted towards online channels, so didcorporates and businesses in each vertical. They responded quick to fill in the gap. The consolidation of corebusiness with outsourcing facilities is the result of an invasive pace of digital transformation of business, aresult of pandemic-led imperative shift in business models.Another issue was that the pandemic speedily locked in countless individuals to 'work from home' (WFH).This created an on-the-spot challenge for a majority of the organizations to produce secure system access toemployees. It witnessed a peremptory reset of organizations to digitization with a new aspect for evolvingdefinition of job roles or modified job description for contemporary corporates. Also, most evidently, ahybrid work-model has emerged that has redefined several corporate rules and processes. The establishedcorporates, tech-driven start-ups, however, managed to support a mass-scale digital training. Thetechnology industry continues to record a positive graph in growth curve in FY2021. However, amongstvarious socio-economic implications of this change, technologically a growing trend to adopt the 3 Cs ofCloud Computing, Collaboration and Cybersecurity to manage the massive data is already visible. Added tothis, a subsequent transition to blockchain for supply change management is vividly noticeable amongstenterprises. This quick adoption of digitization enhanced dependency on advanced digital solutions likecloud computing, amongst others. The resultant rising of the latest job roles that needs technologicallyversatile employees is another ever-changing situation in this context. This research paper deals in thisaspect of the changing trends and tries to critically analyse certain paraphernalia associated to the presenttransformation.
Childcare employment—before, during, and after the COVID-19 pandemic
Authors: Cooksey Kevin , Thomas Emily
Published: January 2024

The employment rate in the United States fell dramatically in many industries during the COVID-19 pandemic—the childcare industry, in particular, was hit hard. In this article, we use data from the U.S. Bureau of Labor Statistics (BLS) Business Response Surveys and other BLS sources to examine employment, wages, telework, benefits, and the inner workings of the critical child daycare services industry before and during the pandemic and most importantly how the industry has managed since. Although the childcare industry’s wages are low and it has high labor turnover, our findings show that it is critical in supporting workers across all industries.
Acknowledgement to Reviewers of Catalysis Research in 2023
Authors: Editorial Office Catalysis Research
Published: January 2024

The editors of Catalysis Research would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2023. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal’s editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the service Publons (https://publons.com) to receive recognition. Of course, in these initiatives we are careful not to compromise reviewer confidentiality. Many reviewers see their work as a voluntary and often unseen part of their role as researchers. We are grateful to the time reviewers donate to our journals and the contribution they make.
Acknowledgement to Reviewers of OBM Neurobiology in 2023
Authors: Editorial Office OBM Neurobiology
Published: January 2024

The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2023. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal’s editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the service Publons (https://publons.com) to receive recognition. Of course, in these initiatives we are careful not to compromise reviewer confidentiality. Many reviewers see their work as a voluntary and often unseen part of their role as researchers. We are grateful to the time reviewers donate to our journals and the contribution they make.
Acknowledgement to Reviewers of OBM Transplantation in 2023
Authors: Editorial Office OBM Transplantation
Published: January 2024

The editors of OBM Transplantation would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2023. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal’s editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the service Publons (https://publons.com) to receive recognition. Of course, in these initiatives we are careful not to compromise reviewer confidentiality. Many reviewers see their work as a voluntary and often unseen part of their role as researchers. We are grateful to the time reviewers donate to our journals and the contribution they make.
Muslim Ban during Trump’s Presidency through the Target Population Framework
Authors: Cahyo Edi Ashari , Lin Poyung , Neupane Kaubin , Topal Reyhan
Published: January 2024

One of the controversies that defined Donald Trump’s presidency was his travel ban policy, which targeted immigrants from many Muslim-majority countries in 2017. While researchers have analyzed the rhetoric, discourse, and indirect speech acts of President Trump and American politicians to fully understand the enforcement of the travel ban, the number of studies investigating how politicians utilize the social construction of immigrants to support or oppose the travel ban is limited. Hence, it is crucial to thoroughly study how political actors socially construct immigrants to justify their policy positions on the travel ban. In this article, we contextualize the travel ban policy within the literature on the social construction of target populations, one of the prominent theories of policy processes. To that end, we examine four types of data sources: legal documents, relevant tweets posted by politicians, think tank publications (op-eds, releases, and commentaries), and news articles published during the travel ban debates. In light of our analysis, we find that not only policymakers but also members of the judicial system, news media sources, and think tanks construct immigrant identities in a way that justifies their policy positions on the travel ban. Our findings underscore the need for a nuanced and well-rounded debate on travel restrictions concerning the reconstruction and reimagination of immigrant identities by various actors. We also contend that future research could greatly benefit from analyzing the social construction of immigrants by different policy actors in a comparative fashion.
Leukocyte Profile of Mice Infected with Plasmodium berghei and Treated with Aqueous Extract of Strychnos Ligustrina and Its Combination with Dihydroartemisinin Piperaquine Phosphate (DHP)
Authors: Cahyaningsih Umi , Sa'diah Siti , Syafii Wasrin , Sari Rita Kartika , Nugraha Arifin Budiman
Published: January 2024

Malaria is still one of the most highly pathogenic diseases, which remains a significant problem for public health. Natural compounds are alternative ways as an antimalarial compound that are applied for the artemisinin combination. The aim of this study was to determine the effect of a combination of S. ligustrina extract and DHP on the differential leukocytes percentages. This study used 100 mice which were divided into five groups. Group A and B were used for the healthy mice and infected-untreated groups, respectively. Group C used as a controlled drug, received 222 mg/kg BW of DHP. Group D received 300 mg/kg BW of aqueous extract of S. ligustrina. Group E received a combination between 111 mg/kg BW of DHP and 200 mg/kg BW of aqueous extract S. ligustrina. The findings demonstrated that DHP and S. ligustrina extract had an impact on neutrophils, lymphocytes, inhibition, and percentages of parasitemia. The findings revealed that treatment groups C, D, and E reduced the percentage of parasitemia. The percentage of neutrophils in treated groups was significantly higher than in group A (P<0.05). The percentage of lymphocytes was lower in the treated groups, while the percentages of eosinophils, monocytes, and basophils did not significantly different (P<0.05). This study found that group D and E had the same effect on the leucocyte profile as group C. Our findings suggest that the aqueous extract of S. ligustrina, as well as the combination treatment with DHP, have the potential to lead to the discovery of new antimalarial medicines.
CONSUMERS’ KNOWLEDGE, ATTITUDE, AND PERCEPTION OF FOOD PRODUCTION SYSTEMS: THE CASE OF THE UNIVERSITY OF NIGERIA NSUKKA, NIGERIA
Authors: ANUGWA IFEOMA QUINETTE , ODO EMMANUEL CHUKWUWEIKE , DIMELU MABEL UKAMAKA , REMILOKOUN OBOSSOU ESDRAS ABREWA
Published: January 2024

Consumers’ knowledge and attitude toward food production systems and its potential impact on the environment drive the demand for food, especially from non-conventional systems. This study seeks to advance the literature on consumers’ preferences for food, by assessing consumers’ knowledge, attitude, and perception of food production systems in the University of Nigeria Nsukka community. Multistage sampling procedure was used in selecting 129 respondents drawn from students, academic, and non-academic staff in the university. Data generated were analyzed using descriptive statistics. The data were collected in-person using a questionnaire. The study revealed that the internet, friends/neighbor, social media, and television were the dominant platforms for sourcing information on the food production systems. The food consumers had little knowledge of genetically modified food products but were quite knowledgeable about organic and conventional food products, respectively. However, they had a positive attitude and perception of food products obtained mainly from organic production system. In addition, the quality of products (M=2.26), income (M=2.14), and cultural beliefs (M=1.54) were some of the factors that affected the intention of consumers to purchase food products obtained from the different food production systems. The study further revealed that packaging of various types of food products (M=1.64) and health implication of consuming food products (M=1.58) were some of information needed by consumers. There is a need for more consumer education in the university community to increase the knowledge of consumers on the health, environmental, and economic benefits of consuming the various food products.
Role of Machine Learning in Cybersecurity: Techniques and Challenges
Authors: Rana Prateek
Published: January 2024

Abstract: Machine learning (ML) plays a crucial role in cybersecurity across various aspects of threat detection, prevention, and response. Here are specific roles and applications of machine learning in cybersecurity. Machine Learning (ML) represents a pivotal technology for current and future information systems, and many domains already leverage the capabilities of ML. However, deployment of ML in cybersecurity is still at an early stage, revealing a significant discrepancy between research and practice. Such a discrepancy has its root cause in the current state of the art, which does not allow us to identify the role of ML in cybersecurity. The full potential of ML will never be unleashed unless its pros and cons are understood by a broad audience. In the computer world, data science is the force behind the recent dramatic changes in cybersecurity's operations and technologies. The secret to making a security system automated and intelligent is to extract patterns or insights related to security incidents from cybersecurity data and construct appropriate data-driven models. Data science, also known as diverse scientific approaches, machine learning techniques, processes, and systems, is the study of actual occurrences via the use of data. Recent breakthroughs in Machine Learning (ML) methods promise new solutions to each of these infamous diversification and asymmetric information problems throughout the constantly increasing vulnerability reporting data-bases. Due to their varied methodologies, those procedures themselves display varying levels of performance. The authors provide a method for cognitive cybersecurity that enhances human cognitive capacity in two ways. To create trustworthy data sets, initially reconcile competing vulnerability reports and then pre-process advanced embedded indicators