bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of FTO in Tumors and Its Research Progress
Authors: Wei Hao , Li Zhen , Liu Fang , Wang Yang , Ding Shi , Chen Ye , Liu Ju
Published: July 2021

Background:

Malignant tumor is a disease that seriously threatens human health.
At present, more and more research results show that the pathogenesis of different tumors is
very complicated, and the methods of clinical treatment are also diverse. This review analyzes
and summarizes the role of fat mass and obesity associated (FTO) gene in different
tumors, and provides a reference value for research and drug treatment methods.

Method:

We conducted a comprehensive literature search using the database. According
to the main purpose of the article, irrelevant articles were excluded from the research
summary and included in the relevant articles. Finally, the relevant information of the article
was summarized.

Result:

In this article, the relationship between malignant tumors and FTO is introduced
by citing many documents. In addition, the inhibitors that act on FTO are listed.

Conclusion:

This article has shown that FTO protein is a demethylase that can regulate
N6-methyladenosine (m6A) levels in mRNA and plays a key role in the progression and
resistance of various tumors such as leukemia, breast cancer, and lung cancer.
Tryptophan Metabolism in Atherosclerosis and Diabetes
Authors: Sudar-Milovanovic Emina , Gluvic Zoran , Obradovic Milan , Zaric Bozidarka , Isenovic Esma R.
Published: July 2021

:

The essential amino acid tryptophan (Trp) undergoes catabolism through several
pathways, producing biologically active metabolites that significantly impact physiological
processes. The metabolic pathway responsible for the majority of Trp catabolism
is the kynurenine synthesis pathway (KP). Serotonin and melatonin are among the most
essential Trp pathways degradation products. It has emerged that a strong relationship exists
between alterations in Trp metabolism and the onset and progression of atherosclerosis
and diabetes.
Atherosclerosis is a chronic inflammatory disease of the small and medium arteries wall
caused by maladaptive local immune responses, which underpins several cardiovascular
diseases (CVD). Systemic low-grade immune-mediated inflammation is implicated in
atherosclerosis where pro-inflammatory cytokines, such as interferon-γ (IFN-γ), play a
significant role. IFN-γ upregulates the enzyme indoleamine 2,3-dioxygenase (IDO), decreasing
serum levels of the Trp and increasing metabolite levels of kynurenine. Increased
IDO expression and activity could accelerate the atherosclerosis process. Therefore, activated
IDO inhibition could offer possible treatment options regarding atherosclerosis
management. Diabetes is a chronic metabolic disease characterized by hyperglycemia
that, over time, leads to severe damage to the heart, blood vessels, eyes, kidneys, and peripheral
nerves. Trp serum levels and lower activity of IDO were higher in future type 2
diabetes (T2DM) patients. This article reviews recent findings on the link between mammalian
Trp metabolism and its role in atherosclerosis and diabetes and outlines the intervention
strategies.
Recent Advances on Multivalent Carbon Nanoform-Based Glycoconjugates
Authors: Ramos-Soriano Javier , Ghirardello Mattia , Galan M. Carmen
Published: July 2021

:

Multivalent carbohydrate-mediated interactions are key to many biological processes including
disease mechanisms. In order to study these important glycan-mediated interactions at a molecular
level, carbon nanoforms such as fullerenes, carbon nanotubes or graphene and their derivatives have
been identified as promising biocompatible scaffolds that can mimic the multivalent presentation of
biologically relevant glycans. In this mini-review, we will summarize the most relevant examples of the
last few years in the context of their applications.
Microglia NLRP3 Inflammasomes Activation Involving Diabetic Neuroinflammation in Diabetic Mice and BV2 Cells
Authors: Li Yuan , Zhang Haifeng , Liu Mingyuan , Guo Weiying , Yu Lu
Published: July 2021

Background:

Hyperglycemia-induced microglia activation can cause a continuous release of proinflammatory
cytokines, which gradually damages neurons and contributes to central diabetic neuroinflammation.

Objective:

This study aimed to illustrate the possible mechanism related to NLRP3 inflammasome and the aggravation
of diabetes neuroinflammation.

Methods:

The targeted proteins from BV2 cells and brain tissues were tested by Western blot or immunohistochemistry.
Cytokines from cell supernatant and serum were detected by ELISA. Meanwhile, cytoplasm and mitochondria
ROS were determined by DCFHDA and Mito sox Red, respectively.

Results:

In vitro, BV2 cells were stimulated by different glucose concentrations (5.5 to 65 mM/L) above physiological
values and maintained for different periods (12 to 48h). The proinflammatory cytokines IL-1β, IL18,
IL6, TNFα and cytoplasm ROS were significantly increased in a dose-dependent manner, while mitochondrial
ROS was unaffected. NLRP3 inflammasomes, MAPKs, and NF-κB pathways were obviously activated at the
concentration of 35 mM/L for 12h. Inhibition assay using specific inhibitors indicated that the treatment of glucose
(35 mM/L for 12h) could stimulate NLRP3 inflammasome activation via ROS/JNK MAPKs/NF-κB pathway.
In STZ induced diabetes mice models, microglia NLRP3, ASC, and caspase-1 proteins were highly expressed,
and serum cytokines IL-1β, IL6, IL18, and TNFα were remarkably increased.

Conclusion:

Microglia NLRP3 inflammasomes activation involves diabetic neuroinflammation in diabetic
mice and BV2 cells via ROS/JNK MAPKs/NF-κB pathways.
TNF-α Inhibitors from Natural Compounds: An Overview, CADD Approaches, and their Exploration for Anti-inflammatory Agents
Authors: da Silva-Júnior Edeildo Ferreira , dos Santos Nascimento Igor José
Published: July 2021

Inflammation is a natural process that occurs in the organism in response to harmful external agents. Despite being considered beneficial, exaggerated cases can cause severe problems for the body. The main inflammatory manifestations are pain, increased temperature, edema, decreased mobility, and quality of life for affected individuals. Diseases such as arthritis, cancer, allergies, infections, arteriosclerosis, neurodegenerative diseases, and metabolic problems are mainly characterized by an exaggerated inflammatory response. Inflammation is related to two categories of substances: pro- and anti-inflammatory mediators. Among the pro-inflammatory mediators is Tumor Necrosis Factor-α (TNF-α). It is associated with immune diseases, cancer, and psychiatric disorders which increase its excretion. Thus, it becomes a target widely used in discovering new antiinflammatory drugs. In this context, secondary metabolites biosynthesized by plants have been used for thousands of years and continue to be one of the primary sources of new drug scaffolds against inflammatory diseases. To decrease costs related to the drug discovery process, Computer-Aided Drug Design (CADD) techniques are broadly explored to increase the chances of success. In this review, the main natural compounds derived from alkaloids, flavonoids, terpene, and polyphenols as promising TNF-α inhibitors will be discussed. Finally, we applied a molecular modeling protocol involving all compounds described here, suggesting that their interactions with Tyr59, Tyr119, Tyr151, Leu57, and Gly121 residues are essential for the activity. Such findings can be useful for research groups worldwide to design new anti-inflammatory TNF-α inhibitors.
Inhibitory Potential of Dietary Nutraceuticals on Cellular PI3K/Akt Signaling: Implications in Cancer Prevention and Therapy
Authors: Narayanankutty Arunaksharan
Published: July 2021

Background:

The phosphatidyl inositol-3 kinase (PI3K)/protein kinase B (Akt)/mechanistic
target of rapamycin (mTOR) signaling has been associated with many cellular physiological
events, such as proliferation, maturation, survival, and metabolism. Besides its role in normal cells,
the pathway is often upregulated in various cancers. Due to its prominent role in the cancer progression
events, it is now being considered as a target for cancer therapy and cancer chemoprevention.

Objectives:

The present review provides a concise outline of the role of the PI3K/Akt/mTOR pathway
in carcinogenesis and progression events, including metastasis, drug resistance and stemness.
Further, emphasis needs to be placed on the PI3K/Akt/mTOR pathway inhibitory potentials of various
food-derived bioactive components in cancer prevention.

Methods:

Data on the PI3K/Akt/mTOR inhibiting natural products and their bioactive compounds
have been obtained from PubMed/Medline, Scopus, Eurekaselect, etc. Findings from the above citation
databases from 2000-2021 are included in the manuscript.

Results:

Numerous compounds from plants have been isolated and identified as anticancer agents;
among these, a predominant class is nutraceuticals. The PI3K pathway is the predominant target of
these natural products, and many of these drug candidates are under various stages of drug development.
These compounds have shown a significant inhibitory effect on the kinase activities of PI3K
and Akt, resulting in the abrogation of cancer initiation and progression events. In addition, these
compounds have been shown to reverse the resistance to chemotherapeutic drugs and also reduce
the population of cancer stem cells.

Conclusion:

The nutraceuticals are promising candidates as anticancer agents by blocking PI3K
signaling cascades. As the PI3K is a central pathway to various receptors signaling, the dietary intervention
may prove to be highly effective.
Indicators of Obesity and Cardio-metabolic Risks: Important Consideration in Adults and Children
Authors: Soheilipour Fahimeh , Hatami Mahsa , Salehiniya Hamid , Alaei Mohammadreza
Published: July 2021

:

The prevalence of obesity has dramatically increased all over the world. Body mass index (BMI) has been used as the most common available measure to determining obesity status. While the site of excessive fat mass accumulation is a stronger determinant of cardio-metabolic complication, with respect to systemic and generalized obesity, which is only determined through BMI. So, it is concluded that using traditional anthropometric indices such as BMI for interpreting the obesity status and cardio-metabolic risk has considerable limitations. Thus, the main aims of the present study are to discuss possible drawbacks of anthropometric indices especially BMI, which in epidemiological studies are usually neglected, as well as lend important consideration to using other anthropometric indices such as measurement of obesity and related cardio-metabolic complications with a special emphasis on the use of waist circumference, waist-to-hip ratio and waist-to-height ratio.
Gangliocytic Paraganglioma of the Gastrointestinal Tract: A Case Report of Cecal Origin
Authors: Seo Geojeong , Park Jinyoung , Lee Eunjoo , Han Jiyeon , Kim Dasom , Kim Donghyun , Park Jungwon , Kwag Minha , Jung Soojin
Published: July 2021

Introduction::

Gangliocytic paraganglioma is an extremely rare tumor that is composed
of epithelioid, ganglion, and spindle cells. It has a predilection site in the duodenum, especially the
periampullary region. The clinical course is usually benign, but a few cases of metastasis to lymph
nodes or distant sites have been noted. Several case reports or small series reviews of gangliocytic
paraganglioma have been published, but so far, cecal gangliocytic paraganglioma has not been described.

Case description:

A 61-year-old man underwent an abdominal Computed Tomography (CT) scan
for known GB stones, which revealed an incidental cecal mass. The patient underwent wedge resection
of the cecum for diagnostic and therapeutic purposes. Histopathological examination of the cecal
mass identified a gangliocytic paraganglioma. There was no evidence of metastasis in the dissected
regional lymph nodes. No additional treatment, such as adjuvant chemotherapy or radiotherapy,
was administered, and the patient underwent regular follow-up without any complications.

Conclusion:

The most common radiologic finding in gangliocytic paraganglioma is a circumscribed,
enhancing subepithelial mass. Herein, we report an uncommon case of cecal-origin gangliocytic
paraganglioma. With knowledge of the radiologic and histologic characteristics of gangliocytic
paraganglioma, appropriate management can be provided without unnecessary radical resection.
The Effect of Phytobiotics Supplementation and Magnetized Drinking Water on Production Performance and Egg Quality of Laying Hens
Authors: Marwi Filoza , Sjofjan Osfar , Mutaqin Adharul , Natsir Muhammad Halim
Published: July 2021

The experiment was conducted to evaluate the production performance and egg quality of laying hens supplemented with phytobiotics and magnetized drinking water. This experiment used 2700 gauss level in Magnetized Drinking Water (MDW). The phytobiotics had two form: the non-encapsulated phytobiotics (PTO) and encapsulated phytobiotics (EPTO). There were untreated water (control) and the treated water (MDW, PTO, PTO+MDW, EPTO, EPTO+MDW). The treatments were presented by 0.6% for each treatment. The result showed highly significant (p<0.01) improvement on feed conversion ratio (FCR) but no significant effect on other production performance variables including feed intake, hen day production (HDP), egg mass, and income over feed cost (IOFC). The results indicated a highly significant improvement (p<0.01) on egg weight and yolk cholesterol. There were no significant effects on shape index (SI), shell weight, shell thickness, Haugh unit (HU), albumen height, yolk weight, yolk index (YI), and yolk color of egg quality variables. It was concluded that the encapsulated form (EPTO and EPTO+MDW) had the best improvement on FCR and yolk cholesterol, on another hand the non-encapsulated form (PTO and PTO+MDW) increased the egg weight of laying hens
The Effectiveness of Gelugur acid (Garcinia atroviridis) Marinade on the Physical Quality of Culled Chicken Meat
Authors: Patriani Peni , Hafid Harapin
Published: July 2021

A method to improve the physical quality of culled chicken meat is required due to the tough texture and faint color of culled chicken meat. High protein content in culled chicken meat makes it easy to experience quality degradation. One of the methods to maintain the quality of post-harvest chicken meat is using spices. Gelugur acid (Garnicia atroviridis) is a spice for cooking spice, sweets, herbs, deodorizing fresh fish, and even cleansing fish before it proceeds into the processing stage. This study aimed to determine the concentration of Garcinia atroviridis which is effective to improve the physical quality of culled chicken meat. This study used a randomized design with 4 treatments and 5 replications. The treatments consisted of T0: without marination using Garcinia atroviridis (as control), T1: marination in 50 g of Garcinia atroviridis + 1000 mL aquadest, T2: marination in 50 g of Garcinia atroviridis + 750 mL aquadest, T3: marination in 50 g of Garcinia atroviridis + 500 mL aquadest. The parameters were the physical quality of meat consisting of meat pH, water holding capacity, tenderness, cooking loss, drip loss and meat color. Based on the results of the study, Garcinia atroviridis marinade had significant effect (P <0.05) on the pH value of the meat, cooking loss, drip loss, tenderness, water holding capacity, and meat brightness. It was concluded that the marination of meat at concentration of 50 g of Garcinia atroviridis + 1000 mL aquadest (T1) was effective in maintaining the pH value, reducing meat drip loss, increasing water holding capacity, increasing tenderness, brightening the color of the meat and maintaining the freshness of the refined culled chicken meat. Marination of meat in concentration of 50 g Garcinia atroviridis + 750 mL aquadest (T2) was also effective in reducing cooking loss of culled chicken meat.
Desarrollo local de las comunidades agrícolas rurales
Authors: Aguilera Peña Roberto Guillermo , Pérez Zulueta Mónica Angelina , Hidalgo Leó José Alonso , Párraga Mendoza Gisella , Solís Argandoña Elisa , León Vega Luisa , Chiriboga Cisneros Fernando , Jaime Carriel Eliot , Mesías Zambrano María Gabriela
Published: July 2021

Como resultado del trabajo del grupo científico- investigativo de Gestión y Conservación del Medio Ambiente, de la Universidad ECOTEC, se presenta hoy esta obra, puesta a consideración del lector como uno de los primeros pasos que en esta materia se dan. El enfoque multidisciplinario aplicado a la investigación, es de suma importancia para la presentación de resultados verdaderamente relevantes, en cualquier campo de la ciencia, considerándose de mayor importancia en temas relacionados al entorno, dado la perspectiva transversal que supone el medio ambiente como ciencia. Conociendo que existen muchas posturas relacionadas al medio ambiente y la interacción del hombre con éste, algunas más fundamentadas que otras, dejamos claro que esta obra reconoce que los recursos ambientales son limitados y que se iniciará una valoración consciente de los bienes y servicios eco-sistémicos
Entorno de las políticas públicas en los sectores productivos del Ecuador
Authors: Macas Acosta Guido Omar , Castro Reyes Daniel Eduardo , Macas Acosta Guido Omar , Monge García Marcelo Geovanny , Monge García Gustavo Vinicio , Dávila Carrión Marco Fabricio , Aguilera Peña Roberto Guillermo
Published: July 2021

El entorno económico, político y social son determinantes claves para el crecimiento y desarrollo económico de un país, por lo que la intervención del Estado no puede pasar desapercibida. Su éxito o fracaso se medirá en los resultados, cualitativos y cuantitativos, que generen las políticas públicas a lo largo del tiempo. Las medidas de asistencialismo que buscan mejorar la calidad de vida de las personas, y las políticas que fomenten la industria, comercio y agricultura siempre tendrán como efecto colateral el de garantizar el emprendimiento, que primero se convertirá en una mejora del nivel de vida de las personas para luego convertirse en un gran generador de empleo y riqueza. De ahí, que la mala aplicación de políticas públicas puede frenar el desarrollo económico, por lo que es importante evaluar y corregir esas medidas con investigaciones académicas que propongan soluciones a corto y mediano plazo.
La mediación: Herramienta jurídica hacia una cultura resolutiva de conflictos de la educación
Authors: Aguirre Jiménez Silvia , Alfonso Caveda Duniesky , Alcívar Trejo Carlos , Domínguez Benavides Alejandro A.
Published: July 2021

La palabra conflicto es ambigua y móvil; según el contexto puede tener diversas interpretaciones y significados, el conflicto es inherente a todo agrupamiento humano, puede orientarnos y conducirnos hacia una comunicación más abierta, hacia soluciones más dialogantes y creativas y a la mejora en general de nuestra conducta, dependiendo de cómo lo afrontemos, a un deterioro constante de las relaciones interpersonales. (Iturbide y Muñoz, 2007) “La Institución escolar forma parte de la sociedad, y en parte, es un reflejo de ella. No es extraño por lo tanto que, en su interior, también se produzcan conflictos” Antúnez (2000, p.9). Esta concepción es la realidad que en ocasiones se presentan dificultades en las relaciones interpersonales entre docentes, directivos, padres de familia y estudiantes, en el área escolar, es necesaria la implementación de programas de resolución de conflictos por vías alternativas, como sucedería con el caso de la mediación, y en situaciones específicas sucedería que, de acuerdo a los lineamientos de cada nivel educativo, la conciliación sería una solución efectiva.
The Ontario Electronic Consultation (eConsult) Service: Cross-sectional Analysis of Utilization Data for 2 Models (Preprint)
Authors: Guglani Sheena , Liddy Clare , Afkham Amir , Mitchell Rhea , Keely Erin
Published: July 2021

BACKGROUND

The Ontario electronic consultation (eConsult) service allows a primary care provider (PCP) to access specialist advice through 2 models: the direct-to-specialist (DTS) model, where PCPs select a specialist from a directory, and the Building Access to Specialists Through eConsultation (BASE)–managed specialty service, where PCPs choose a specialty group and are assigned a specialist from a qualified pool based on availability.

OBJECTIVE

The aim of this study is to examine patterns of use between the 2 models of eConsult delivery.

METHODS

We conducted a cross-sectional analysis of utilization data collected from eConsults completed between October 2018 and September 2019. Cases were grouped based on the model used for submission (ie, BASE or DTS). Each model was assessed for the number of cases over time, specialty distribution, proportion resulting in new or additional information, impact on PCPs’ decisions to refer, and billing time.

RESULTS

PCPs submitted 26,121 eConsults during the study period. The monthly case volume increased by 43% over the duration of the study, primarily in the BASE model (66% compared to 6% for DTS). PCPs were able to confirm a course of action that they originally had in mind in 41.4% (6373/15,376) of BASE cases and 41.3% (3363/8136) of DTS cases and received advice for a new or additional course of action in 54.7% (8418/15,376) of BASE cases and 56.3% (4582/8136) of DTS cases. A referral was originally contemplated but avoided in 51.3% (7887/15,376) of BASE cases and 53.3% (4336/8136) of DTS cases, originally contemplated and still needed in 19.4% (2986/15,376) of BASE cases and 17.7% (1438/8136) of DTS cases, and neither originally contemplated nor needed in 21.7% (3334/15,376) of BASE cases and 21.9% (1781/8136) of DTS cases.

CONCLUSIONS

Both eConsult models had strong uptake. Use patterns varied between models, with the majority of growth occurring under BASE, but survey responses showed that both models provided similar outcomes in terms of new information offered and impact on decision to refer.
Modified Usability Test Scenario: User Story Approach to Evaluate Data Visualization Dashboard
Authors: Kadir Nurul Tiara , Hartanto Rudy , Sulistyo Selo
Published: July 2021

The data processing results are commonly displayed in a dashboard with various graphic visualization forms to deliver new knowledge easier to understand by users. However, many data analysis dashboards cannot communicate the knowledge effectively and efficiently given the unsuitable design implementation. Therefore, research to measure the interface display's effectiveness in the data analysis system is deemed necessary. This research proposed a scenario modification in the usability test with a user story approach to measuring the system interface display in delivering the information to users. The approach of a usability test with the user story is expected to be capable of helping the researcher in understanding the user habits indirectly. There were 20 participants to validate the proposed method. Participants were asked to use the system and answer several questions to develop their user experience. After developing user experience for each user, the System Usability Scale (SUS) was conducted. SUS score results obtained from this research was 75.25. Besides, the researcher also measured the understanding level among the users using questionnaires. The questionnaire results were converted into numbers and resulted in a mean value of 91.8. Those two values indicate the users' ability to use the system well and obtain the new knowledge displayed in the data analysis dashboard.
A Review on Face Anti-Spoofing
Authors: Perdana Rizky Naufal , Ardiyanto Igi , Nugroho Hanung Adi
Published: July 2021

The biometric system is a security technology that uses information based on a living person's characteristics to verify or recognize the identity, such as facial recognition. Face recognition has numerous applications in the real world, such as access control and surveillance. But face recognition has a security issue of spoofing. A face anti-spoofing, a task to prevent fake authorization by breaching the face recognition systems using a photo, video, mask, or a different substitute for an authorized person's face, is used to overcome this challenge. There is also increasing research of new datasets by providing new types of attack or diversity to reach a better generalization. This paper review of the recent development includes a general understanding of face spoofing, anti-spoofing methods, and the latest development to solve the problem against various spoof types.
Discussing Subsidiarity in Terms of Justification
Authors: Pimenova Oxana
Published: July 2021

This article attempts to study the inter-institutional dimension of the practical implementation of the subsidiarity principle in the EU legislative process. The main research question is whether the subsidiarity principle could be a real communicative tool in the EU’s multi-level regulation policy used to seek consensus between EU institutions and national parliaments on the justification of an appropriate level for EU actions (subsidiarity justification). The short answer is ‘yes’. Through the content analysis of the published documents and with the help of the theory of deliberation, the author argues for a subsidiarity justification procedure occurring at the beginning of each instance of the EU legislative process to provide an inter-institutional setting to move away from confirming (one-way) to deliberative (two-way) reasoning over the issue of potential subsidiarity violation in the EU legislative process.
A Review Paper on Automatic Coin Sorter for Temples using IOT
Authors: Parteki Prajakta P.
Published: July 2021

At non-secular places like temples, gurdwaras, and lots of others, devotees gift cash within the donation box. It's a giant deal to sight the truth of the given cash. Similarly, cash numeration has been a giant task because it is allotted manually. Mistakes on numeration happen most of the time because of several reasons like eyes temporary state, losing focus, etc. typically fiddle of cash happens at the time of numeration money. To prevail over these issues Automatic Coin Sorter for Temples using IOT is meant. During this system, the truth of the coin is detected employing a dimension standardization method. Then the coins when some delay area unit sorted and area unit inserted into the various assigned box with the assistance of the motor. All the data regarding the coin is distributed to the Associate in Nursing digital display wherever the worth, reality, and count of the coin area unit are displayed. The overall count of the noon and full-day is distributed to the various head person through the applying. The advantage of this review paper for the reader is to achieve information about numerous technologies used for creating this method.
ESPOTIFY (An Emotion Based Music Player)
Authors: Shukla Pushkal Kumar
Published: July 2021

Human emotion plays an essential role in social relationships. Emotions are reflected from verbalization, hand gestures of a body, through outward appearances and facial expressions. Music is an art form that soothes and calms the human brain and body. To analyze the mood of an individual, we first need to examine its emotions. If we detect an individual's emotions, then we can also detect an individual's mood. Taking the above two aspects and blending them, our system deals with detecting the emotion of a person through facial expression and playing music according to the emotion detected that will alleviate the mood or calm the individual and can also get quicker songs according to the emotion, saving time from looking up different songs. Different expressions of the face could be angry, happy, sad, and neutral. Facial emotions can be captured and detected through an inbuilt camera or a webcam. In our project, the Fisherface Algorithm is used for the detection of human emotions. After detecting an individual's emotion, our system will play the music automatically based on the emotion of an individual.
A Review of Heavy Metal Toxicity, Effects and Methods for Estimating Heavy Metal Concentration in Water
Authors: Shaik Laharshitha Kajol
Published: July 2021

Heavy metals are metal ions which acts as carcinogens and causes serious health issues as they produce free radicals and these free radicals cause damage to DNA which eventually leads to cancer. They are non-degradable in nature and responsible for contamination of various natural resources in environment mainly water contamination has become a major problem. Many metal ions such as cadmium, lead, arsenic, mercury are considered as toxic metals. The analysis of these metal ions is necessary and to detect these metal ions, several detection methods such as electrochemical biosensors, CNT’s, silver nanoparticles have been developed. In this paper, the toxicity and health effects of several heavy metals and their role in causing of oxidative stress have been summarized. Also, various heavy metal detection methods have been listed.
Automation in Monitoring of Hydroponics for Tomato
Authors: Varughese Indu Reena
Published: July 2021

Nowadays, as the population is increasing widely, it becomes necessary for the cultivation of plants without the utilization of many land resources. There are different types of soil present on earth and different crops need different types of soils. Due to scarcity of water, it becomes difficult for the farmers to cultivate crops on land which requires a lot of water. With a hydroponic system in which the farmer has more control over plant growth, can get very high yields. In conventional methods, farmers need to monitor as well as manually control the parameters required for the efficient growth of the plants frequently. We have a sensing unit that senses various parameters like pH, Total Dissolved Salts (TDS), temperature, and humidity. The gathered information regarding these parameters is fed to the Arduino and monitored continuously. The Arduino is programmed such that whenever there is a change in these parameters from the optimum value, an alert message is sent to an android application installed in the smartphone.
Automatic Waste Collection & Segregation
Authors: Shaikh Rehan
Published: July 2021

Rapidly growing urbanization and increasing population in all over the world, causing dynamic increase in the amount of waste disposal. Dumping of waste has become a matter of concern all over the world because of the threat to the environment. There comes the pivotal role of the automatic waste segregation system which avoid this unfortunate situation and it also reduces the difficulty of recycling. Currently there is no such system for segregation of metal, dry, and wet waste. This work proposes a On spot automatic waste segregation system that gives the solution to this problem. The benefits of this work are, high potential for waste recovery and the occupational hazards of waste separating workers also reduces.
BloodLine IOT Based Blood Bank Management System
Authors: Rastogi Mr. Deependra
Published: July 2021

BloodLine offers new horizons for health that gives aid services by utilizing the mobile devices and communication technologies. In health care services, blood donation could be a advanced method and consumes time to search out some donor who has the compatibility of people with the patient. The planned system is an android primarily based blood bank application to determine a affiliation between the requester and donor at anytime and anyplace. A bank as we all know provides blood to folks in would like now and then of emergency. The bank system is intended in such the way that users will read the knowledge concerning registered blood donors which is able to facilitate within the hour of would like. The planned system includes a login page wherever the user is needed to register, however user doesn't got to register if he doesn't notice the specified result. The user also can register to give blood on the system if they want to. therefore this technique helps to pick out the proper donor instantly using people. the most aim of developing this technique is to scale back the time to an excellent extent that's spent in searching for the proper donor and also the convenience of blood needed. therefore the planned system provides the desired info quickly and additionally helps in faster higher cognitive process.
Automobile Online Service Portal
Authors: Ansari Mohd Saad Umair
Published: July 2021

In Today’s era where almost everything has moved their services online. Delivery of Groceries, Food, Electronics, and even Furniture have adopted smart ways to provide services. The approach is to provide a portal that will help in the reduction of manual tasks as much as possible. The goal is to bring service providers and customers on one platform. This Portal if modified, can also be used by other service providers that work based on appointment. Dealers can list their features along with their prices. For better interaction with customers, Portal also provides Customer Feedback and Customer Grievance, both are one on one services that are helpful in productivity and customer relationship. So, the simple approach is providing a system that will reduce the manual tasks, for instance, customers can book an appointment as necessary and the service provider will a time slot accordingly. Implementation is web-based.
Phytochemical Analysis of Selected Indigenous Medicinal Plants in Quirino Province, Cagayan Valley, Philippines
Authors: E. Co Annalene Grace
Published: July 2021

Medicinal plants have bioactive components which are used for curing various human diseases. They also play an essential role in healing. Fresh fruits and leaves of collected plant samples were used following standard solvent extraction protocol and qualitative analysis to detect secondary plant metabolites. The ethanolic extracts of eight indigenous medicinal plants of Quirino Province, Cagayan Valley, Philippines, were subjected to phytochemical analysis. Results confirmed alkaloids, saponins, phytosterols, phenolic compounds, and flavonoids in specific extracts. The inferences of the findings are discussed in light of the role of indigenous plants in the traditional medicinal system.
Practical Study of Residential Society
Authors: Mote Prof. P. S.
Published: July 2021

The project of this residential building was very successful. It has all the amenities that can make life easier and happier. We have take this project to understand the function and system to build a best residential buildings in future which will help us to achieve good knowledge of work and things to be considered while construction of residential buildings. This project has help us to achieve practical experience and basic concepts clearly. Also we learned how to take care of clients desirable flat and how to build according to that. We have learnt how to build the amenities like club house, gym, kids play area, jogging track, etc and give them a great infrastructure for eg. Jogging track :- it should have concrete blocks arranged in a patterned colour and track should be surrounded with plant's and tree's and width of the track should be spacious. We also learned how to build and where to build the things that must have in the flats and building of residential construction that includes lift, Refuge area, electricity connection , fire alarming system installation, etc. In this project we did taken part in the plan of flat construction and we observed the process from making wall till painting and finishing of it. We did helped to build the wall and coloum construction with the help the workers and under the guidance of chief engineer. By the help of this project we learned to use our knowledge at best level and construction of buildings that is good in infrastructure, good for comfortable and lavish lifestyle and at reasonable cost. Overall this project has given us practice experience and knowledge so that we can perform better and give out best in our career as a civil engineer.
Structural Audit and Retrofitting of RCC Structure
Authors: Humnabad Azharuddin
Published: July 2021

Civil Engineering Industry is one of the oldest industries which provide a basic infrastructure to all the human beings. Structures can be any kind it can be Historical, Heritage Structure, Residential building, Commercial building or an Industrial building. Every structure has its own service life, and within this service life it should stand firmly on its position. Ex- A Taj Mahal in Agra in India which is one of the oldest structures and a Wonders of the World, and still stand on its position very efficiently. But this not a condition about the today’s Structures. A collapsed mechanism has increased and today’s Structures are getting collapsed before there service life is completed. Therefore, it is advisable to monitor it periodically by taking a professional opinion. Structural Audit is a preliminary technical survey of a building to assess its general health as a civil engineering structure. It is usually initiated as the first step for repair. In this Project a Root Cause of a faulty mechanism of structure and a preventive measure to overcome a failure of this structures. The construction material mainly reinforced concrete is being used extensively for various types of construction projects. However, the deterioration of Reinforced Concrete structures is recognized as a major problem worldwide. Apart from requiring regular maintenance, many structures require extensive Repair, Rehabilitation & Retrofitting. Over a period of time, as these structures become older, we find in them certain degradation or deterioration with resultant distress manifested in the form of cracking, splitting, delaminating, corrosion etc. Such deteriorated structures can be rehabilitated and retrofitted by using various types of admixtures & modern repair materials. The paper brings out the present state of concrete structures & the major areas where improvement is needed during its service life stage for sustainable development & also the method of carrying out Repair, Rehabilitation &Retrofitting. This has been brought in details in the paper along with Case studies, where the Author of the paper was directly involved in planning and execution of the job.
Strength Determination of High Strength Concrete Blended with Copper Slag and Fly Ash
Authors: Alam Jamshed
Published: July 2021

An experimental analysis was conducted to study the effects of using copper slag as a fine aggregate (FA) and the effect of fly ash as partial replacement of cement on the properties high strength concrete. In this analysis total ten concrete mixtures were prepared, out of which five mixes containing different proportions of copper slag ranging from 0% (for the control mix) to 75% were prepared and remaining five mixes containing fly ash as partial replacement of cement ranging from 6% to 30% (all mixes contains 50% copper slag as sand replacements). Concrete matrix were tested for compressive strength, tensile strength and flexural strength tests. Addition of copper slag as sand replacement up to 50% yielded comparable strength with that of the control matrix. However, further additions of copper slag, caused reduction in strength due to an increment of the free water content in the mix. Concrete mix with 75% copper slag replacement gave the lowest compressive strength value of approximately 80 MPa at 28 days curing period, which is almost 4% more than the strength of the control mix. For this concrete containing 50% copper slag, fly ash is introduced in the concrete to achieve the better compressive, split and flexural strengths. It was also observed that, introduction of the fly ash gave better results than concrete containing 50% copper slag. When concrete prepared with 18 % of fly ash, the strength has increased approximately 4%, and strength decreased with further replacements of the cement with fly ash. Hence, it is suggested that 50% of copper slag can be used as replacement of sand and 18% fly ash can be used as replacement of cement in order to obtain high strength concrete.
Digital Photo Frame Printing using 3D Printer
Authors: More Chetan
Published: July 2021

3D printing gives life to all your best projects. Do you know that it could also give life to your picture? Yes, you read it right, if you have a picture of it then you can turn it into a 3D model and 3D print it! From 1 to 100 hundred pictures, several effective solutions are available to help you convert photos into a 3D model.
The Art of Writing an Article
Authors: Avadhani C. L.
Published: July 2021

The advent of information technology and the required information at the finger tips by using search engines writing an article is not that much difficult as it before. Hence, the author should be very careful in preparing a manuscript, citing the references, preparing an abstract and a good title, otherwise the article is likely to be rejected by the publishers. If the title is heart, abstract is the soul then eyes and ears are references and reviews. Title is a most important part of an article because it is a gateway to the content of a research article. A good title to the research article is the one which is able to focus the research work to the fullest extent. Likewise, an abstract is like a trailer and should give stimulation to the reader to go through the entire article. On the other than if the reader is unimpressed with the information in the abstract the reader will never read the article and the very purpose of publishing an article is nullified. A good abstract should be honest, trustworthy and summary of the manuscript with a continuity of thoughts. The purpose of references in any article is to identify and locate the source of information used for justifying the need for conducting the research work. While citing the references the author should take into account by giving the relevant citations in an appropriate manner as desired by the editorial board of the Journals. The other obligatory on the part of an author of an article is he should satisfy not only the editorial board of any Journal but also the peer reviewers whose comments are necessary for publication. Peer Review is an important element in the research process before publication and this review makes the road either to publish or to reject the article. It is important for the author while submitting the manuscript to prepare a covering letter and it should contain why this article is important to the journal and its readers. The author while preparing the manuscript should follow the ethics according to the nature and subject matter. The author should be careful in choosing the relevant subject the source of information, preparing right title, scripting good abstract and finally an acceptable manuscript.
Unusual Crowd Activity Detection Using Open CV and Motion Influence Map
Authors: G S Chaya
Published: July 2021

Suspicious behavior is dangerous in public areas that may cause heavy causalities. There are various systems developed on the basis of video frame acquisition where motion or pedestrian detection occur but those systems are not intelligent enough to identify the unusual activities even at real time. It is required to recognized scamper situation at real time from video surveillance for quick and immediate management before any casualties. Proposed system focuses on recognizing suspicious activities and target to achieve a technique which is able to detect suspicious activity automatically using computer vision. Here system uses OpenCV library for classifying different kind of actions at real time.
On Fixed Point Result in Double Controlled Metric Spaces
Authors: Singh S. S. P.
Published: July 2021

In this paper, we introduce Hardy and Rogers type contractions in the class of double controlled metric spaces and establish fixed point theorem. Our result are generalization of some known results of literature. We also provide example to illustrate significance of the established result .
Criminal Records Information Retrieval System: A Conceptual Model
Authors: Sonawale Nitin
Published: July 2021

This model helps to increase communication between Police and public. It will reduce time & increase the problem solving efficiency in time period it will be more helpful. In this admin is key person, user(police) is also have secure registration & public can communicate with all other users through mail. Here we are going to use clustering technique because it more powerful to forming accurate cluster, speed of creating cluster, identifying crime trend & crime zone ,crime density of state.
Seismic Effects on Different Structural Members
Authors: Gajbhiye Shobhit
Published: July 2021

Civil engineers deal with constructing differing types of structures with guaranteeing safety, sturdiness and utility. Currently days “earthquake “is a natural tragedy that affects the structures with their safety and utility. The quantity of harm that earthquake will cause to structures is rely upon sort of building, sort of soil, Technology used for earthquake resistance, and last however not the smallest amount Location of building. Effects of earthquake area unit mostly counting on sort of soil within which foundation of building is finished as a result of earthquake changes the motion of ground that results the failure foundation. Therefore it's vital to check the behavior of various soils at the time of construction of structures. Earthquake will be resisted by varied technologies utilized in building, one amongst these area unit shear wall. It improves the structural performance of building subjected to lateral forces because of earthquake excitation. Much analysis comes area unit afoot worldwide for development of effective ways for estimating unstable demands for performance-based engineering of buildings.
Micro- Level Audit of Segregation, Collection, Transportation, Treatment and Disposal of Municipal Solid Waste at Source of Dhantoli, Nagpur
Authors: Pandharipande Ms. Jui
Published: July 2021

: A micro-level audit of the Municipal Solid Waste Management system was carried out for centrally situated Dhantoli locality of Nagpur, Maharashtra. Dhantoli being a very elite locality of Nagpur was facing problems due to increasing municipal solid waste. Waste quantification was carried out to find the total amount of waste generated per day from the locality and the percentage of biodegradable and non-biodegradable waste was also determined. The waste sample was analyzed for its characteristics and its results indicated that organic waste was highest among other components of the waste. The outcomes of the audit also highlighted the lacunae in the collection and transportation system of the locality. Considering all the parameters, a decentralized composting plant was suggested for the treatment and disposal of biodegradable waste; while for the non-biodegradable waste establishment of a Material Recovery Facility (MRF) center was proposed.
Brain Tumor Prediction Using Neural Network
Authors: Srivastava Smriti
Published: July 2021

Brain Tumor is a disease in which there is an abnormal growth of mass that occurs inside human brain that can led to death also. The detection of brain tumor takes places through MRI scan images. For doctors sometimes it becomes difficult to differentiate between tumour cells and nerve cells. Even sometimes what happens is that unstructured shape of tumours led it make difficult for doctors to identify tumours in brain. Artificial intelligence is one of the most trending technologies now a day through which machines gets the power to think and take decisions on its own. This paper uses the power of Artificial Intelligence to detect Brain tumour in human brain.
Edge Computing - The Way Forward
Authors: Jain Aayush
Published: July 2021

As of late, the Edge Computing worldview has acquired significant notoriety in scholastic and mechanical circles. It fills in as a key empowering influence for some, future advances like 5G, Internet of Things (IoT), augmented reality by interfacing distributed computing offices and administrations to the end clients. The Edge registering worldview gives low idleness, versatility, and area mindfulness backing to delay-delicate applications. Edge figuring can possibly address the worries of reaction time necessity, transmission capacity cost saving, just as information wellbeing and protection. In this paper, we present the meaning of edge Computing, trailed by a few contextual investigations, going from cloud offloading to smart home and city.