bluuebunny/crossref_metadata_2025 huggingface dataset:
BIOLOGIA REPRODUTIVA DE COTESIA FLAVIPES (CAM.). II. EFEITO DE MÚLTIPLAS CÓPULAS SOBRE O NÚMERO DE POSTURAS, RAZÃO SEXUAL E LARVAS QUE EMERGEM DO HOSPEDEIRO DIATRAEA SACCHARALIS (F.)
Authors: Campos-Farinha A.E. de C. , Chaud-Netto J.
Published: February 2025

RESUMO Fêmeas de Cotesia flavipes (Cam.) que copularam com um e dois machos foram colocadas, individual..: mente, em placas de Petri na presença de lagartas de 5º ínstar de Diatraea saccharalis (F.). O número de posturas realizadas, bem como o número de parasitóides emergidos e larvas inviáveis foram registrados. A razão sexual da prole também foi verificada. Foi observado que as fêmeas são basicamente monogâmicas e que preferem ovipositar apenas uma vez na lagarta hospedeira. O número de ovos depositados, a razão sexual da prole e o número de larvas inviáveis produzido pelas vespas que copularam com um e dois machos foi semelhante, mesmo quando elas fizeram posturas em número variável. Estes resultados sugerem que uma segunda cópula não influencia o valor adaptativo da prole deste parasitóide.
ARTRÓPODOS PRESENTES EM CAMINHÕES QUE TRANSPORTAM MATÉRIAS-PRIMAS E PRODUTOS TERMINADOS DA INDÚSTRIA ALIMENTÍCIA: IDENTIFICAÇÃO E PERSPECTIVAS DE CONTROLE
Authors: Chaves L.E.L. , Berti Filho E.
Published: February 2025

RESUMO Com o objetivo de avaliar a presença de artrópodos no interior de caminhões que transportam matériasprimas e produtos terminados para a indústria alimentícia foi realizado um levantamento entre os meses de outubro de 1996 e outubro de 1997. Como metodologia amostral utilizou-se aspiração de 224 carrocerias vazias de caminhões baú, cujo tempo variou em relação à metragem cúbica dos compartimentos. Cada amostra foi analisada visualmente e estereoscopicamente 24 horas e 70 dias após sua coleta. Os indivíduos coletados foram identificados, quando possível, e submetidos à análise faunística de freqüência e constância. Os resultados apontaram a aspiração como procedimento válido a ser incorporado pelas indústrias para avaliações rápidas de presenças de artrópodos em carrocerias, sendo que estas apresentaram-se bastante suscetíveis à entrada desses animais. Insetos das Ordens Psocoptera e Hymenoptera foram freqüentes e ácaros constantes. Como prática de controle, a limpeza criteriosa e freqüente apresenta-se como a alternativa mais viável e que tende a apresentar melhores resultados para retirar indivíduos acidentais e contra a possibilidade de aumento populacional destes em seu interior.
FIRST OCCURRENCE OF THE BURROWING NEMATODE (RADOPHOLUS SIMILIS) ON GINGER (ZINGIBER OFFICINALE) IN BRAZIL
Authors: Oliveira C.M.G. , Inomoto M.M.
Published: February 2025

ABSTRACT The burrowing nematode, Radopholus similis, is reported infecting ginger, Zingiber officinale, in Brazil for the first time. Also, in the sarne material, Meloidogyne javanica was detected provoking galls on the rhizomes.
ESTRIA BACTERIANA DO PAINÇO CAUSADA POR ACIDOVORAX AVENAE SUBSP. AVENAE
Authors: Malavolta Jr. V.A. , Oliveira M.A.R. de , Almeida I.M.G. de
Published: February 2025

RESUMO Em novembro de 1995, na região de Cascavel, PR, foram observadas, em cultivos comerciais de painço (Panicum miliaceum L.), plantas apresentando anomalias nas folhas e na panícula. Nas panículas os sintomas eram de crestamento, atingindo principalmente a ráquis e, ao evoluir, causavam a sua morte. Nas folhas ocorria a presença de estrias pardacentas, de diferentes comprimentos, que quando coalesciam causavam a destruição de extensas regiões do limbo foliar. De materiais apresentando essa sintomatologia foram isoladas bactérias caracterizadas através de testes bioquímicos, fisiológicos, culturais, serológicos e de patogenicidade como Acidovorax avenae subsp. avenae (sin. Pseudomonas avenae), ainda não assinalada como patogênica a essa cultura no Brasil. Isolados foram incorporados à Coleção de Cà1lturas IBSBF sob nllS 1228 e 1229. 1,
The underappreciated contribution of Oskar Fischer to the knowledge of Frontotemporal Lobar Degeneration
Authors: Engelhardt Eliasz , Grinberg Lea Tenenholz
Published: February 2025

ABSTRACT Frontotemporal Lobar Degeneration (FTLD) encompasses progressive neurodegeneration primarily affecting the frontal and/or temporal lobes, presenting in varied pathological entities. These pathologies lead to diverse clinical syndromes collectively known as Frontotemporal Dementia (FTD), which includes a behavioral variant, and primary progressive aphasia, with its non-fluent and semantic variants, and related conditions with parkinsonism or motoneuron disease features. The historical development of FTD concept is rooted in the pioneering work of Arnold Pick, who first described clinical cases of focal brain atrophy. Oskar Fischer significantly advanced this field by detailing the histopathological features of these conditions, such as the ‘spongiform cortical wasting’, and identifying characteristic neuronal changes such as the ‘ballooned cells’. Fischer’s contributions, alongside those of contemporaries like Alois Alzheimer, laid the foundation for understanding FTLD histopathology. Here, Fischer’s overlooked work is spotlighted, advocating for a greater recognition, which he rightfully deserves for his contributions to the field of neurodegenerative diseases.
Sentinels of environmental change: shifts in fish diversity through the lens of artisanal fishers
Authors: Santos Marco Aurélio Alves , Pelicice Fernando Mayer
Published: February 2025

Abstract River regulation has caused significant shifts in fish diversity, with severe impacts on small-scale artisanal fisheries, which depend on fishing resources for income, employment and food security. This study investigated how artisanal fishers perceive changes in fish diversity in response to river regulation, considering four facets: (i) fish abundance, (ii) species records, (iii) capture patterns, and (iv) most valued fish. Between August and October 2018, we conducted systematic interviews with 30 artisanal fishers that operate in the area impounded by Lajeado Dam (middle Tocantins River). Fishers mentioned 60 common names of fish, totaling 51 independent ethnospecies. According to fishers, non-migratory fishes flourished in the reservoir, while migratory fishes declined. Fishers mentioned nine taxa that appeared in the impounded area, and 20 that disappeared, mainly large migratory catfishes. Fishery catches before river regulation were composed of large migratory characids and catfishes, while landings in the reservoir were composed of mid-sized non-migratory fish. Fishers also reported changes in the composition of the most valued fish. These results expand the evidence that artisanal fishers identify major shifts in fish diversity following river regulation, demonstrating that they can act as permanent sentinels of environmental change and degradation.
Work and Confrontation with the Real for Health Professionals During COVID-19
Authors: Máximo Thaís Augusta Cunha de Oliveira , Torres Tatiana de Lucena , Moura Erick Idalino , Silva Wesley Jordan Pereira da , Vasconcelos Lucas Eurikes Melo , Cruz Rian Enedino Pereira
Published: February 2025

Abstract: Healthcare professionals faced significant challenges as they worked on the front lines during the COVID-19 pandemic. This study aimed to analyze the work activity of health professionals and the implications for their mental health and subjectivity considering their conditions, organization and work routines, which were modified in view of their urgency of action in combating COVID-19. This is a qualitative exploratory study, in which 51 semi-structured interviews were conducted with health professionals from the Brazilian Unified Health System during the months of May to September 2021. The results were analyzed using the Iramuteq textual analysis software and interpreted with the Psychodynamics of Work theory. The analyzes showed the precariousness of work characterized by unpredictability and contradictions, generating fear and a sense of exposure to risks that negatively impacted the physical and mental health of workers.
Femininas, modestas e antifeministas: o ativismo on-line de mulheres católicas tradicionais
Authors: Santos Jaqueline Sant’ana Martins dos
Published: February 2025

Resumo: O presente artigo tem por objetivo analisar o ativismo conservador e antifeminista realizado por mulheres católicas tradicionais a partir do conteúdo disponibilizado em sites e blogs autorais dedicados à divulgação da prática da “modéstia cristã no vestir” e seus principais valores, tais como feminilidade, exaltação da maternidade e defesa da “família tradicional”. A partir desses espaços virtuais, que evidenciam um engajamento feminino na difusão de discursos teológicos de fundo moral, examinamos discursos e mobilizações de cunho antifeminista que compõem cruzadas antigênero que vêm impactando o cenário político e religioso contemporâneo, dada a sua configuração de atuação em redes, conectando indivíduos em grupos que buscam incidir no debate público sobre os temas família, educação, sexualidade e direitos.
A missão nos ambientes digitais na perspectiva de uma Igreja sinodal: respostas católicas à “Reforma digital”
Authors: Sbardelotto Moisés
Published: February 2025

Resumo: Este artigo examina a resposta da Igreja Católica à transformação digital - também chamada, em seus efeitos no campo religioso, de “Reforma digital” (Drescher 2011) - a partir da convocação do Sínodo sobre a Sinodalidade, feita pelo Papa Francisco em 2021. Este artigo explora teoricamente, em primeiro lugar, as mudanças que a cultura digital provoca no catolicismo, com base nos conceitos de “Reforma” e “Contrarreforma” digitais. Em seguida, com base em pesquisa bibliográfico-documental, analisa os nove documentos resultantes daquele processo sinodal, particularmente do chamado “Sínodo digital”. Conclui-se que tal processo explicita a tentativa eclesial de se adaptar à comunicação em redes digitais na contemporaneidade, que desdobra novos significados para a própria ideia de comunhão, participação e missão, temas centrais nos debates sinodais.
Garantia da saúde mental e bem-estar de servidores públicos em Moçambique no âmbito dos Objetivos de Desenvolvimento Sustentável: avanços, limites e perspectivas
Authors: Aliante Gildo , Scorsolini-Comin Fabio , Abacar Mussa , José Coutinho Maurício , Macedo Alice Costa
Published: February 2025

Resumo Introdução A garantia da saúde mental e bem-estar de servidores públicos constitui uma ação necessária para a materialização das políticas públicas nacionais e o alcance das metas dos Objetivos de Desenvolvimento Sustentável. Objetivo Conhecer os avanços, limites e perspectivas da garantia da saúde mental e bem-estar de servidores públicos em Moçambique. Métodos Pesquisa qualitativa, desenvolvida por meio de análise documental e bibliográfica. Resultados A partir de 2016, houve a incorporação de elementos de trabalho decente na legislação laboral vigente, a saber: ingresso no Estado por via de nomeação provisória, condições adequadas de higiene e segurança no trabalho, equidade salarial e justiça laboral. Porém, na realidade, a concretização desses direitos é uma utopia, uma vez que as instituições públicas funcionam em um cenário de austeridade e de pouco investimento público, o que limita a provisão de condições de trabalho adequadas, recursos humanos e oportunidades de desenvolvimento na carreira. Ademais, constatou-se um quadro de sofrimento e adoecimento mental de servidores públicos que se manifesta em sintomas de estresse, burnout, depressão e alcoolismo. Conclusão É mister transformar os direitos legislados em prática no contexto moçambicano, no esteio dos avanços ocorridos em outras partes do mundo.
Analysis of clinical and pathological prognostic factors of survival in rectal adenocarcinoma treated with preoperative radiochemotherapy
Authors: Saad Sarhan Sydney , Forones Nora , Lopes Filho Gaspar , Waisberg Jaques , Caetano Júnior Elesiario , Artigiani-Neto Ricardo , Matos Delcio
Published: February 2025

ABSTRACT Purpose: To identify the prognostic variables related to the survival of patients operated on for adenocarcinoma of the rectum who underwent preoperative radiochemotherapy (RCT). Methods: We studied 70 patients from the Discipline of Surgical Gastroenterology at Escola Paulista de Medicina from 2000 to 2019, with rectal cancer located up to 10 cm from the anal verge and with stages II or III, submitted to preoperative RCT and curative surgery (R0) and with follow-up of at least 12 months. Clinical restaging was performed four to six weeks after the end of neoadjuvant treatment to characterize the degree of clinical tumor regression. Surgery by laparotomy or videolaparoscopy was performed six to 12 weeks after RCT. Primary endpoint were: overall survival (OS), disease-free survival (DFS), metastasis-free survival (MSS), and neoplasm-specific survival (SEN). These were compared with gender, age, carcinoembryonic antigen (CEA) dosage, distance from the tumor to the anal verge, radiation dose, radiotherapy-surgery interval, clinical regression, type of surgery, pT and pN TNM stage tumor, number of nodes, circumferential resection margin, and complete pathological response. Survival was assessed by Kaplan-Meier curves. Univariate and multivariate Cox analyses were calculated to identify factors associated with survival outcomes. Results: The mean follow-up time was 62 months. The pathological complete response rate was 18.6%. Univariate cox regression showed a significant relationship of CEA equal to or greater than 4 ng/mL with DFS and MFS, pT3/pT4 staging with DFS, MFS and SEN, pN1/N2 with DFS, MFS and SEN and stages II and III with DFS and MFS. Multivariate regression found that CEA, pT, and pN staging are independent prognostic factors for DFS, MFS, and SEN. Conclusion: Carcinoembryonic antigen level prior to radiotherapy, pT staging and pN staging were independent prognostic factors for survival in patients with rectal adenocarcinoma who are treated with preoperative radiochemotherapy.
A Method for PIO Suppression in Aircraft with Fly-By-Wire Controls: System Development and Validation via Flight Simulator Tests
Authors: Miranda Rafael Morales , Bidinotto Jorge Henrique
Published: February 2025

ABSTRACT This article introduces a technique for suppressing pilot-induced oscillations (PIO) in aircraft equipped with fly-by-wire (FBW) flight controls. Drawing from the real-time oscillation verifier (ROVER) concept proposed by Mitchell and Hoh, in 1994, and an adaptive suppression system by Moura in 2018, the method involves dynamically adjusting stability derivatives via software during aircraft operation. The ROVER detects PIO conditions during flight, directing changes to the aircraft’s dynamics. Switching to a less susceptible model during PIO mitigates oscillations. The study focuses exclusively on longitudinal motion and pitch angle control. The proposed system is implemented and simulated using MATLAB routines, complemented by human pilot trials on a flight simulator. Results demonstrate real-time detection of PIO oscillations and effective mitigation, ensuring system integrity with acceptable degradation in flight qualities during transitions.
Entre reparação histórica e justiça social: as ideias subjacentes às políticas de ações afirmativas nas universidades públicas
Authors: Rodrigues Neto Damasio , Schabbach Letícia Maria
Published: February 2025

Resumo O artigo examina quais ideias fundamentaram a adoção das ações afirmativas por universidades públicas brasileiras (federais e estaduais), no período entre 2001 e 2012, anteriormente à promulgação da “Lei Federal de Cotas” (BRASIL, 2012), e como essas ideias influenciaram distintas políticas de acesso ao ensino superior. A metodologia envolveu análise de conteúdo de documentos oficiais pertencentes a 54 universidades públicas (resoluções de conselhos superiores, atas de reuniões, editais públicos, dentre outros). Conclui-se que as ideias mais recorrentes referem-se a: justiça social, reparação histórica, diversidade e meritocracia. Também se constatou que o argumento da reparação histórica foi predominante para a delimitação do problema e sua inclusão na agenda das instituições, ao passo que a ideia de justiça social foi mais influente no desenho dos programas, tratando-se de um ideal abstrato que não se vincula, necessariamente, a um tipo específico de política de cotas.
VERTEBRAL PEDICULAR TETHERING - GROWTH MODULATION TECHNIQUE FOR IDIOPATHIC SCOLIOSIS
Authors: BARROS ANDRÉ SANTOS DE , BIZARRO PEDRO , JORDÃO PEDRO , CAMPAGNOLO JOÃO LAMEIRAS , MINEIRO JORGE
Published: February 2025

ABSTRACT Objectives: This study aimed to evaluate Vertebral Pedicular Tethering (VPT) as a less invasive alternative to traditional spinal fusion in Adolescent Idiopathic Scoliosis (AIS), focusing on thoracolumbar and lumbar curves (Lenke 5C and 6C) in growing patients. The objective was to correct scoliosis without fusion, preserving spinal mobility and growth. Methods: A series of six female adolescents underwent VPT, three of whom had over six months of follow-up. The procedure applied posterior compression on the convex side of the scoliotic curve, utilizing the Hueter-Volkman principle to modulate growth and correct deformity. Outcomes were evaluated in the coronal, sagittal, and rotational planes using radiographic measurements and clinical assessments. Results: The main Cobb angle improved by an average of 67.5% (34.8°) over six months, with spinal length increasing by an average of 7 mm. Vertebral rotation also improved, with a reduction from Nash-Moe grade +3 to +1. However, one patient experienced over-correction, requiring tether release. Sagittal plane analysis showed increased kyphosis in the proximal segment and improved lordosis in the thoracolumbar region without hyperlordosis. Conclusions: VPT demonstrated promising results in correcting spinal deformities while preserving mobility and growth in selected AIS patients (Sanders stages 3-5). The technique offers a viable alternative to fusion, particularly in thoracolumbar curves. However, the procedure’s timing is crucial to avoid over-correction or insufficient growth modulation. Further research with longer follow-ups and larger cohorts is needed to refine patient selection and improve outcomes. Level of Evidence IV; Case Series.
Os donos do Supremo: dinâmica de liderança e protagonismo da Presidência do STF
Authors: Correa Marona Marjorie , Recondo Freire Felipe , Campos Rocha Mariela , Fernandes de Magalhães Lucas
Published: February 2025

Este estudo analisa a evolução do papel da Presidência do Supremo Tribunal Federal (STF) no Brasil, destacando sua crescente relevância política e institucional. A pesquisa investiga como os presidentes do STF ampliaram sua influência, saindo de uma função predominantemente cerimonial para uma posição de grande protagonismo. A principal pergunta de pesquisa é: como a presidência do STF exerce sua representação institucional e quais fatores determinam sua atuação? O estudo utiliza a análise das agendas institucionais dos presidentes entre 2001 e 2021 para identificar padrões e variações na atuação presidencial. Os resultados indicam que o perfil dos ministros e o contexto político influenciam diretamente o grau de protagonismo da presidência. O estudo propõe uma tipologia das presidências do STF, classificando-as em modelos cerimoniais, negociadores, independentes e protagonistas. A conclusão aponta que a presidência do STF se tornou um ator político central, desempenhando um papel estratégico na governabilidade e na mediação entre os poderes. Essa transformação institucional reflete a crescente judicialização da política e a necessidade de maior transparência e articulação por parte do Judiciário.
Implementing the effect of geopolymer concrete pore solution pH in the standard rapid migration test NT Build 492 protocol
Authors: Pang Yu , Nguyen Quang Dieu , Castel Arnaud
Published: February 2025

This research investigates the impact of the pore solution pH values on chloride content at the colour change boundary determined according to the standard rapid migration test (NT Build 492), with a focus on alkali-activated materials, so-called geopolymer. The study investigates a range of geopolymer formulations using various proportions of ground granulated blast furnace slag (GGBFS), fly ash, and calcined clay, alongside different activator concentrations, to examine their influence on the pH value of the pore solution. Findings from this study suggest that the pH value of the pore solution greatly influence in the chloride ion concentration at the colour change boundary, which should be accounted for in the calculation of the non-steady-state migration coefficients (Dnssm). It is noted that mixtures with higher GGBFS content exhibit higher pH values than mixtures containing fly ash or calcined clay, impacting the Dnssm. The results advocate for modifications to the standard NT Build 492 protocol to enhance its applicability and accuracy for geopolymer materials, emphasizing the importance of using revised Dnssm values calculated considering the unique properties of geopolymer concrete for more durability assessment.
PIEZO1-Mediated Calcium Signaling and Podocyte Injury in Diabetic Kidney Disease
Authors: Li Weiwei , Zhang Zongwei , Peng Zhuan , Hu Hongtu , Cui Xiaofei , Zhu Zijing , Qi Yue , Chen Wenjie , Liu Hongyan , Liang Wei , Ding Guohua , Chen Zhaowei
Published: February 2025

Background:

Diabetic kidney disease (DKD) is characterized by progressive injury to glomerular podocytes due to sustained mechanical stress within the glomerulus. Piezo proteins, acting as cellular mechanosensors, play a pivotal role in mechanotransduction by sensing mechanical forces and regulating intracellular ion flux. This study investigates the role of Piezo1 in the progression of DKD and its mechanistic involvement in podocyte injury.

Methods:

Podocyte-specific Piezo1 knockout mice were generated using the streptozotocin plus high-fat diet model of DKD. In vitro studies included the use of Piezo1 inhibitors to assess calcium influx, podocyte cytoskeletal rearrangement, and apoptosis under stiff matrix conditions. Additionally, nuclear factor of activated T cell cytoplasmic 1 (NFATc1) and transient receptor potential cation channel 6 (TRPC6) signaling pathways were explored to establish their role in Piezo1-mediated podocyte injury. Adeno-associated virus -TRPC6 was utilized to overexpress TRPC6 in podocyte-specific Piezo1 knockout mice to assess the in vivo interaction between Piezo1 and TRPC6.

Results:

Podocyte-specific deletion of Piezo1 significantly ameliorated the progression of DKD in diabetic mice. Inhibition of Piezo1 reduced calcium influx, cytoskeletal rearrangement, and podocyte apoptosis in vitro. Mechanistically, Piezo1 activation triggered a signaling loop involving NFATc1 and TRPC6, leading to increased calcium influx, perpetuating podocyte injury. TRPC6 overexpression in vivo counteracted the protective effects of Piezo1 deletion, confirming the critical role of the Piezo1/NFATc1/TRPC6 axis in DKD progression.

Conclusions:

Piezo1 plays a key mechanosensory role in podocyte injury during DKD progression by mediating calcium influx and activating the NFATc1/TRPC6 signaling pathway.
Ptprz Signaling, Tubule- and Macrophage-Mediated Kidney Injury, and Subsequent CKD
Authors: Weinmann-Menke Julia , Gonzalez-Sanchez Hilda M. , Iwata Yasunori , Meineck Myriam , Abassi Najla , Marini Federico , Granados-Contreras Francisco , Takakura Ayumi , Noda Masaharu , Kelley Vicki Rubin
Published: February 2025

Background:

Macrophages and tubular epithelial cell interactions are integral in kidney ischemia-incited interstitial inflammation leading to acute kidney injury. Ischemia/reperfusion injury riggers tubular epithelial cells to express IL-34, a macrophage growth factor, that promotes acute kidney injury and subsequent chronic kidney disease. IL-34 engages the cognate receptor, c-FMS, expressed by macrophages, and the recently discovered Protein-Tyrosine Phosphatase ζ (Ptprz). Ptprz, binds to multiple ligands other than IL-34 that progressively increase their expression in kidneys after ischemia/reperfusion injury.

Methods:

We tested the hypothesis that signaling through Ptprz promotes macrophage-mediated acute kidney injury and subsequent chronic kidney disease, by comparing Ptprz knockout with wild-type mice after ischemia/reperfusion injury.

Results:

Ptprz was expressed by leukocytes and in tubular epithelial cells after ischemia/reperfusion injury in mice. Using Ptprz knockout mice we determined that during acute kidney injury and chronic kidney disease kidney pathology, and loss of kidney function were ameliorated. Ptprz-dependent mechanisms mediated: (i) tubular epithelial cell expression of chemokines that fostered macrophage and T cell rich renal inflammation, and (ii) tubule injury and apoptosis, that resulted in the loss of tubules and interstitial fibrosis during chronic kidney disease . Mechanistically, Ptprz dependent tubule epithelial cells released mediators that:(i) promoted tubule cytotoxicity, and thereby, shortened tubule survival, and (ii) stimulated Ptprz expressing macrophages to generate mediators that induce kidney destruction. These findings are translational, as after ischemia reperfusion injury in human kidney transplants, PTPRZ and PTPRZ ligands were upregulated and expressed by the same cell populations as in mice. Moreover, PTPRZ levels in sera were elevated in kidney transplant patients.

Conclusions:

Intra-renal Ptprz-dependent macrophage and tubular epithelial cell mediated mechanisms promote acute kidney injury and subsequent chronic kidney disease.
Nuestro vínculo con los animales. Guía práctica: política pública de protección y bienestar animal para el departamento de Cundinamarca
Authors: Suárez Díaz Yenifer Yiseth , Aya Gloria del Pilar , González Niño Juan Camilo , Arévalo Nelson
Published: February 2025

Esta cartilla aborda la implementación de políticas para mejorar el bienestar animal en la región. A través de un análisis exhaustivo, se identifican problemas críticos como el maltrato, el abandono y la falta de recursos para el cuidado adecuado de los animales. Este documento destaca la necesidad de mayor conciencia y educación sobre la importancia del bienestar animal entre la población. Se detallan las normativas vigentes que regulan la protección animal, haciendo énfasis en la importancia de su implementación y cumplimiento, incluyendo leyes contra el maltrato y regulaciones sobre la tenencia responsable de animales. La cartilla presenta un árbol de problemas que visualiza los principales desafíos en la protección animal y sus causas subyacentes, como la falta de educación y recursos, y sus efectos, como el aumento de animales en situación de calle y el deterioro de la salud pública.
Luontotavoitteiden mittareiden ja vertailutilan valinnan merkitys: Näkökulmia EU:n biodiversiteettistrategian sekä kansallisen luontostrategian ja toimintaohjelman konkretisoimiseksi
Authors: Lakka Hanna-Kaisa , Bäck Jaana , El Geneidy Sami , Elo Merja , Herzon Irina , Jokimäki Jukka , Kulmala Liisa , Laine Ilona , Lehikoinen Aleksi , Nieminen Tiina , Oksanen Elina , Pappila Minna , Paulomäki Hanna , Peura Maiju , Puurtinen Mikael , Silfverberg Outi , Sinkkonen Aki , Sääksjärvi Ilari , Kotiaho Janne
Published: February 2025

Tämän mietinnön tarkoitus on lisätä ymmärrystä luontosopimusten ja -strategioiden tavoitteista.
Functional state of the kidneys in patients with various types of cerebrovascular diseases
Authors: Murkamilov I.T. , Aitbaev K.A. , Fomin V.V. , Hakimov Sh.Sh. , Shchendrigin I.N. , Solizhonov J.I. , Yusupova T.F. , Yusupova Z.F. , Yusupov F.A.
Published: February 2025

Objective. To study the functional state of the kidneys in men and women with various types of cerebrovascular diseases (CVD). Material and methods. The study included 378 patients with CVD: transient ischemic attack (TIA), stroke (ischemic and hemorrhagic), and chronic brain ischemia. The average age of men and women was 61.4±13.0 and 63.8±11.8 years, respectively. The excretory function of the kidneys was assessed in all participants. Results. TIA was recorded in 20.9% of men and 13.4% of women. Stroke was verified in 35.7% of patients (56.4% men and 34.3% women, p<0.05). Recurrent ischemic stroke was more common in men (12.9%) than in women (6.9%, p<0.05). The frequency of proteinuria was 34.1%, with nephrotic proteinuria and hematuria more often noted in men. The functional state of the kidneys (optimal, slightly reduced, moderately reduced, and significantly reduced excretory function) was identified in 37.8%, 34.1%, 17.7%, and 6.3% of patients, respectively. Severely reduced kidney function was recorded in 3.4% of patients. The glomerular filtration rate according to the CKD-EPI (67.9±24.1 ml/min), MDRD (62.9±22.8 ml/min), and Cockcroft-Gault (67.7±24.4 ml/min) formulas was lower in men compared to women (78.3±25.3 ml/min, 76.3±3.2 ml/min, 81.2±36.5 ml/min, p<0.05). In men and women, a correlation was established between pathomorphological changes on brain MRI and the level of red blood cells, glucose, total cholesterol and creatinine. Conclusion. In patients with CVD, the frequency of proteinuria is 34.1%. Nephrotic proteinuria and hematuria are more common in men. Changes in the functional state of the kidneys are manifested as slight and moderate reductions in excretory function. In women, the excretory function of the kidneys and proteinuria are closely related to pathomorphological changes in the brain.
Epidemiology of multiple sclerosis in the city of Novosibirsk
Authors: Arkhipov I.E. , Prokaeva A.I. , Tretyakova E.V. , Korobko D.S. , Malkova N.A.
Published: February 2025

Objective. To study the dynamics of the epidemiological characteristics of multiple sclerosis (MS) from 01.01.2003 to 01.01.2024 in Novosibirsk in comparison with the previous 20-year study. Material and methods. The prevalence cohort included 2254 patients with MS living in Novosibirsk on 01.01.2024. The cohort of cases included 1998 patients with the onset of the disease from 01.01.2003 to 31.12.2023 inclusive. In order to level out the influence of heterogeneous sex and age composition of the population of Novosibirsk, the method of standardization of indicators was used in the study (standard European population, 13.07.2013). The results of our analysis were compared with the results of the previous epidemiological study in the city of Novosibirsk (Malkova N.A., 2005). Results. The prevalence of MS as of 01.01.2024 was calculated as 137.83 per 100 thousand population (standardized indicator — 123.43). The average age of the patients with MS was 46.146±0.479 years. The ratio of men to women was 1:2.1. The incidence of MS from 2003 to 2023 shows a trend toward an increase (5.12±0.0662 to 7.71±0.0246 per 100 thousand population/year (p<0.05), which is mainly due to a significant increase in the proportion of women (6.56±0.1118 to 11.01±0.091 per 100 thousand population/year, p<0.05), but not men (p>0.05). The average age of MS onset increased by 0.146 years annually during the study period and amounted to 30.479±0.329 years (rxy=0.08, p<0.001). An increase in the incidence of early-onset and late-onset MS was also noted (rxy=0.45, p=0.041 and rxy=0.622, p=0.003, respectively). A significant decrease in the «onset—diagnosis» interval was recorded (mean 5.28±6.41 years on 01.01.2003; mean 1.77±0.921 years on 01.01.2024). Conclusions. In the era of controlled disease progression, our study showed an increase in the prevalence of MS from 2003 to 2023 (54.4 to 137.83 per 100 thousand population). The dynamics of the sex ratio of patients with MS in Novosibirsk does not demonstrate the global trend with a 3—4-fold increase in the proportion of women. An increase in the incidence of MS was noted from 2003 to 2023 (p<0.05), mainly due to women (p<0.05). The age of MS onset has increased significantly over the 20-year period (27.73±0.6 years in 2003; 30.479±0.329 years in 2023). A separate trend towards an increase in the incidence of early-onset and late-onset MS is shown (rxy=0.45, p=0.041 and rxy=0.622, p=0.003, respectively). In part, the increase in the epidemiological characteristics of MS is associated with a decrease in the «onset—diagnosis» interval (p<0.05), which is due to improved diagnostic criteria and health care services.
The experience of diagnosing Alzheimer’s disease based on the study of cerebrospinal fluid biomarkers
Authors: Nevzorova K.V. , Shpilyukova Y.A. , Fedotova E.Yu. , Burmak A.G. , Shabalina A.A. , Illarioshkin S.N.
Published: February 2025

Objective. To evaluate the frequency of Alzheimer’s disease (AD) confirmed by cerebrospinal fluid (CSF) biomarkers in a cohort of patients with classical (amnesic) and atypical phenotypes of this disease. Material and methods. The study included 63 patients (24 men and 39 women; median age 65 years [60; 71]). All patients were divided into 3 groups according to the phenotype: a classic amnesic phenotype (n=32), frequent non-amnesic phenotypes (n=21) and rare non-amnesic phenotypes (n=10). All patients underwent lumbar puncture followed by the CSF biomarkers evaluation (beta-amyloid 1—42 (Aβ1—42) and phosphorylated tau protein 181 (p-tau181)) to confirm the AD pathology. The clinical characteristics of each subgroup were studied. Results. A decreased level of CSF Aβ1—42 in combination with an increased level of p-tau181 was found in 36 patients (57.1%). A change in at least one biomarker was detected in 54 patients (85.7%). The highest frequency of the Alzheimer’s type pathology was found in the group with predominant amnestic phenotype (87.5%), as well as in the subgroups with logopenic variant of primary progressive aphasia (lvPPA) (100%) and with posterior cortical atrophy (PCA) (100%). In the group with rare phenotypes, the frequency of AD CSF changes characteristic of AD was 50% for patients with predominant behavioral disorders and 66.7% for corticobasal syndrome. Conclusion. The high frequency of AD CSF biomarkers in both the classical (amnesic) and atypical phenotypes is shown. This indicates the need to expand the use of AD CSF biomarkers for a more reliable assessment of the prevalence of AD In Russia.
The association of NOS1AP gene polymorphisms with the duration of the QT interval in patients with schizophrenia receiving antipsychotic therapy
Authors: Kornetova E.G. , Galkin S.A. , Mednova I.A. , Tiguntsev V.V. , Paderina D.Z. , Ivanova S.A.
Published: February 2025

Objective. To study the associations of NOS1AP gene polymorphisms with the duration of the QT interval (QTc) in patients with schizophrenia receiving antipsychotics. Material and methods. One hundred and sixty-eight patients (78 men and 90 women) with an established diagnosis of schizophrenia were examined. The patients received basic antipsychotic therapy. At the time of admission to the hospital, a standard 12-lead electrocardiogram recording was performed. The calculation of the QTc interval was carried out using the Bazett formula. Three NOS1AP polymorphisms (rs12029454, rs10494366 and rs12143842) were selected for genotyping. Results. Spearman’s correlation revealed a significant relationship between CPZeq and the duration of the QTc interval in the group of men (rs=0.262; p=0.021; pBonf=0.042). CPZeq was positively correlated with the duration of the QTc interval in men with AA and AG rs12029454 (rs=0.717; p=0.00025; pbonf=0.0015), GG and GT rs10494366 (rs=0.381; p=0.008; pbonf=0.048), TT and CT rs12143842 (rs=0.389; p=0.003; pbonf=0.018) genotypes. We did not find any significant correlations in the group of women. Conclusion. Genetic variants rs12029454, rs10494366 and rs12143842 of the NOS1AP gene are associated with the duration of the QTc interval in men with schizophrenia in response to antipsychotics. The AA/AG rs12029454, GG/GT rs10494366 and TT/CT rs12143842 genotypes in men contribute to the prolongation of the QTc interval and the development of undesirable cardiovascular disorders against the background of antipsychotic therapy.
An exploration of students’ and academics’ experiences of the Recognition of Prior Learning process for admission to postgraduate studies
Authors: Snyman Maria
Published: February 2025

In the recognition of prior learning (RPL) process that is completed for access to undergraduate studies, students and academics are the key participants. Their experience of the process appears to be under-investigated, given the limited number of these studies that have been conducted at distance learning institutions. Therefore, it is important to explore the perceptions and experiences of academics and students of the RPL process, in order to make meaningful suggestions for improving the process. This research explored the RPL experiences of students and academics in the postgraduate context, at an open distance learning (ODL) institution. Research participants who were directly involved in the RPL process, as applicants and as academic assessors, were involved. It was established that, apart from granting them admission to postgraduate studies, RPL candidates also benefited from the process on personal, as well as academic levels. The main aspect of RPL, preparation of evidence for assessment, similar to those of sustainable assessment, contributes to students becoming aware of their learning potential. Aspects of the RPL process, that both candidates and academics found beneficial, were illuminated during this research project. The academics gained insight into the candidate learner profile, while candidates experienced the process as beneficial; both for gaining admission and the postgraduate context.
Barragem Do Banguê
Authors: Sousa Maria Ismênia Leite de , Cunha Júnior Henrique
Published: February 2025

The present study deals with the memories of the construction of the Banguê Dam as a determinant in the civilizing production of the history of Assaré, linked to the protagonism of the black population of the place. The research aims to study the use of African-based techniques and technologies in the formation of cities belonging to Cariri Ceará. The Banguê Dam, an artificial water reservoir built in the mid-19th century, using the work of enslaved labor, but which was recognized in the history of the place as being created by the colonizer. To carry out the research, the methodology of Afro-descendants was used, associated with oral history with the use of narrative interviews with residents who had knowledge about the formation of the Alto de Banguê neighborhood. Given the ideologies imposed by Eurocentrism in the framework of the origin of cities in the interior of Ceará, there is a lack of knowledge in identifying Afro-descendant belonging in the production of cities. In this way, our interest in presenting possibilities for developing geography teaching, using the spatialities of the place in the production of the territory linked to the local slave past, positive the belonging of the black population at the origin of the municipality.
Estudo e Adaptação Preliminar de um Protocolo de Avaliação Rápida Para Ambientes Lênticos, em Presidente Prudente (São Paulo/ Brasil)
Authors: Ziliotto Beatriz Garcia , Romero Danielli Cristina Granado
Published: February 2025

Amid the context of urban transformation that extends from the earliest settlements along the banks of rivers and streams to the present day, it is evident that in the process of urban planning and occupation, these water bodies were often perceived as barriers that limited and shaped the urban layout. The objective of this study was to develop a study for the adaptation of a rapid assessment protocol focused on lentic environments in Presidente Prudente, São Paulo. This study fills a theoretical gap by addressing the lack of specific adaptations for lentic environment assessment protocols. The research was conducted through literature reviews comparing the characteristics of lentic and lotic environments, and the results revealed that lentic environments exhibit several characteristics that differentiate them from lotic environments, highlighting the need for continuous adaptations in the assessment protocol. This analysis not only contributes to academic knowledge but also points to the need for more effective and sustainable management practices concerning these ecosystems.
Hate Speech Directed at Spanish Female Actors: Penélope Cruz—A Case Study
Authors: Tello Díaz Lucía , Martínez-Valerio Lizette
Published: February 2025

Penélope Cruz is one of the most internationally acclaimed Spanish performers. However, despite her successful career, she is also one of the celebrities subject to most controversy on social media and the most frequent target of hate speech. Although she does not manage her own profile on X (previously Twitter), her name and criticism of her are constant on this platform. The objective of this study is to detect possible hate speech, as well as to categorise it by its intensity and typology. The study analyses the unrestricted comments on X containing the name Penélope Cruz posted during the period between January and June 2023. The methodology utilised is that of quantitative and qualitative content analysis of the comments registered (N = 6,620). One of the chief results is the fact that the majority of the comments classified as hate speech refer to ideological issues (70.9%) and/or are misogynistic (8.9%), among which are the specific allusions to her acting skills and her physical characteristics. The results coincide with other studies in which hate messages directed at actresses are related to their physical appearance. However, they differ in that in this case the main type of hatred is not misogyny, but ideological hatred. The actor is not only accused of being a “communist” and a “hypocrite” for her lifestyle, but also for having used her body to succeed in her profession. Both her physique and intellectual capacity are also subject to hate speech. Most of these messages are based on conjecture, prejudice, and stereotypes.
Long-Term Trends in Microseismicity During Operational Shut-Ins at the Coso Geothermal Field, California
Authors: Holmgren Joanna M. , Kaven J. Ole , Oye Volker
Published: February 2025

Pausing injection and production can lead to induced seismicity in a variety of settings, with some of the largest events occurring during these so-called shut-ins. In geothermal fields, shut-ins are periodically conducted for the maintenance of wells and surface infrastructure, thereby offering recurring means of estimating stress changes in the subsurface that lead to increased seismicity rates. Here, we examine daily production and microseismicity data from the Coso geothermal field (CGF) in California between 1996 and 2010 to investigate the repetitive trends of operational shut-in microseismicity. Using 24 local seismic stations, we first analyze spatial and temporal trends of over 60,000 earthquakes with magnitudes between −0.4 and 3.8. We find that the northern region exhibits no significant seismicity changes during shut-ins, whereas the rest of the field experiences induced seismicity during almost every shut-in with an increasing intensity toward the southern and eastern portions of the field, possibly highlighting local differences in stress within the CGF. In addition, we cluster the seismicity using waveform cross-correlation, revealing several earthquake clusters primarily occurring during shut-in periods. These observations suggest that certain fracture and fault sections respond rapidly to changes in pore pressure and poroelastic stresses within the geothermal system, possibly highlighting main fluid pathways.
Providencia de Dios (Tratado de la inmortalidad del alma y Tratado de la divina providencia)
Authors: López Poza Sagrario
Published: February 2025

Providencia de Dios, obra de madurez de Francisco de Quevedo (1580-1645), fue escrita en los años 1641-1642, mientras el escritor sufría prisión en el Convento Real de San Marcos de León. La obra se estructura en dos tratados (sobre la inmortalidad del alma, y sobre la providencia divina) que consideran los principales temas de la apologética del siglo XVII. Con esta obra Quevedo pretende demostrar que es un profesional capaz de acometer asuntos propios de la oratoria sagrada, diferentes a aquellos por los que es más conocido (de índole satírica y burlesca). Esta es la primera edición crítica de Providencia de Dios, con profusa anotación y precedida de un amplio y detallado estudio donde se contextualiza la obra, se analiza su estructura, los aspectos retóricos y estilísticos, la erudición, el desarrollo argumentativo, la transmisión textual, fuentes y filiación. Se acompaña de apéndices con detallada descripción de fuentes manuscritas e impresas, aparato crítico, índice de voces y conceptos anotados, bibliografía y abreviaturas.
Sagrario López Poza, ha publicado abundantes estudios sobre Quevedo a partir de su primer libro: Francisco de Quevedo y la literatura patrística (1992). Reseñas: Henry Ettinghausen, La Perinola, 20 (2016),  pp. 371-376; Samuel Fasquel, eHumanista, 34 (2016), pp. 570-573.
Determining The Risk of Cardio- and Vasotoxicity of Antitumor Therapy: to Whom, When, Why?
Authors: Vasyuk Yu. A. , Muslov S. A. , Vyzhigin D. A. , Shupenina E. Yu. , Novosel E. O.
Published: February 2025

It is known that the advances in cancer treatment leading to increased survival in malignant neoplasms, entail a variety of adverse cardiovascular toxic effects that can be quite serious and even potentially fatal. An important component that influences the degree of cardiotoxicity risk is the patient’s clinical and functional state and the cardiovascular history at the time of cancer diagnosis. This information can be used in practice for the cardiovascular screening and clinical and functional evaluation of a patient with a neoplasm before the start of antitumor therapy. After completion of the cardiotoxic therapy, as well as during subsequent follow-up, it is advisable to re-evaluate the risk of long-term cardiotoxicity to determine the frequency and intensity of cardiovascular monitoring. For convenience of calculating the risk of cardiotoxicity in cancer patients undergoing the antitumor treatment, the authors of this article have developed two computer programs that can be used as PC applications (https://disk.yandex.ru/d/NuhzYnicWo9FSw) and on mobile devices (https://disk.yandex.ru/d/uXAriKZ6qhkULA.). These programs facilitate the selection of the correct strategy for the management of cancer patients that is aimed at reducing the likelihood of cardiotoxic complications of the antitumor treatment.
Correlation between Obesity and Epicardial Fat Volume in Patients With Coronary Artery Disease: From the Alternative Cardiovascular Bio-Imaging Markers Registry
Authors: Xu Can , Wang Dongjing
Published: February 2025

Background. The primary objective was to investigate the relationship between and obesity and epicardial fat volume (EFV) in individuals diagnosed with coronary artery disease (CAD), with the aim of determining whether a consistent linear relationship exists among these factors.Material and methods. This cross-sectional study involved a total of 510 participants. To explore the relationship between EFV and obesity in CAD patients, we controlled for potential confounding variables, including age, sex, diabetes mellitus, smoking history, arterial hypertension, hypercholesterolemia, hypertriglyceridemia, statin use, vasculopathy, and prior acute myocardial infarction.Results. After adjusting for confounding factors, a non-linear relationship was observed between obesity and EFV, with an inflection point identified at 200 ml. The effect sizes and their respective confidence intervals were 1.02 (CI: 1.02-1.03) and 0.99 (CI: 0.98-1.00) on either side of this inflection point. Below a EFV of 200 ml, a positive correlation between obesity and EFV was apparent.Conclusion. The relationship between obesity and EFV in CAD patients is non-linear, and this should be considered when developing prognostic models for CAD. The findings suggest that the relationship between EFV and obesity is more complex than previously thought and warrants further investigation to better understand its implications for both CAD and obesity risk assessment and management.