bluuebunny/crossref_metadata_2025 huggingface dataset:
Ticagrelor inverse agonist activity at the P2Y12 receptor is non-reversible versus its endogenous agonist ADP.
Authors: Khalil Jawad , Dimofte Tudor , Keith Michael , Roberts Tim , Bancroft Sukhinder , Hutchinson James , Naseem Khalid , Johnson Tom , Mundell Stuart
Published: June 2022

Background: Ticagrelor is labelled as a reversible, direct-acting
platelet P2Y12 receptor (P2Y12R) antagonist that is indicated clinically
for the prevention of thrombotic events in patients with acute coronary
syndrome (ACS). As with many antiplatelet drugs, ticagrelor therapy
increases bleeding risk in patients which in emergency situations
requires platelet transfusion although there is ongoing debate on its
effectiveness following ticagrelor therapy. The aim of this study was to
further examine the reversibility of ticagrelor at the P2Y12R. Methods:
Studies were performed in human platelets with both P2Y12R-stimulated
GTPase activity and platelet aggregation assessed. Cell-based
bioluminescence resonance energy transfer (BRET) assays were also
undertaken to assess G protein subunit activation downstream of P2Y12R
activation. Results: Initial studies revealed a range of P2Y12R ligands
including ticagrelor displayed inverse agonist activity at the P2Y12R.
Of these only ticagrelor was resistant to wash-out. In both human
platelets and cell-based assays, washing failed to reverse
ticagrelor-dependent inhibition of ADP-stimulated P2Y12R function in
contrast to other P2Y12R antagonists. The P2Y12R agonist 2MeSADP, which
was also resistant to wash-out, was able to effectively compete with
ticagrelor. In silico docking revealed that ticagrelor and 2MeSADP
penetrated more deeply into the orthosteric binding pocket of the P2Y12R
than other P2Y12R ligands. Conclusion: Ticagrelor binding to the P2Y12R
is prolonged and more akin to that of an irreversible antagonist
especially versus the endogenous P2Y12R agonist ADP. This study
highlights the potential clinical need for novel ticagrelor reversal
strategies in patients with spontaneous major bleeding and bleeding
associated with urgent invasive procedures.
Inhibition of E3 ligase Pellino-1 attenuates chronic obstructive pulmonary disease and lung cellular senescence by promoting p21 degradation
Authors: Ma Jia-hui , Zhang Yi-ting , Wang Lu-ping , Sun Qing-yu , Zhang Hao , Li Jian-jiang , Han Ning-ning , Zhu Yao-yao , Xie Xiao-yu , Li Xia
Published: June 2022

Background and Purpose Chronic obstructive pulmonary diseases (COPD) are
age-related, airflow-obstruction diseases mostly caused by cigarette
smoke. However, the relationship between COPD and lung cellular
senescence is still not fully understood. Here, we investigated how E3
ligase Pellino-1 mediated COPD and lung cellular senescence.
Experimental Approach We used western blot, qPCR and co-IP assays to
analyze the correlation of Pellino-1 and P21 in cells with or without
silencing Pellino-1. Then we used flow cytometry, immunofluorescence
staining and β- galactosidase assay to analyze the influences of
silencing Pellino-1. Furthermore, we constructed COPD and aging models
in vivo. Adenovirus of knock-down and overexpression Pellino-1 was used
to infected mice. Immunohistochemistry and HE staining were used to
analyze the lung pathology. Key Results Here, we first found that the E3
ubiquitin ligase Pellino-1 could bind to senescence marker p21 and
modify p21 by K63-site ubiquitination and verified with silencing
Pellino-1. Furthermore, we found that p21-mediated lung cellular
senescence could be inhibited by silencing Pellino-1. Moreover, by
constructing an adenovirus mouse model, we found that silencing
Pellino-1 could inhibit COPD and inflammation via reduction of SASPs
regulated by p21. Resistomycin, a potential Pellino-1 inhibitor,
interrupts the interaction between Pellino-1 and p21, which accelerates
the ubiquitin-dependent degradation of p21 and consequently inhibits
lung cellular senescence and COPD progression. Conclusion and
Implications Our study elucidated that inhibition of E3 ligase Pellino-1
exhibits therapeutic potential for treatment to attenuate the
progression of lung cellular senescence and COPD.
COVID-19 Vaccine-Induced Tolosa-Hunt Syndrome: A Case Report
Authors: Morgenstern-Kaplan Dan , Waxman Daniel Salame , León-Mayorga Yasshid , Nuñez-García Edgar
Published: June 2022

We present the case of a previously healthy 36-year-old male with right
eye discomfort, associated diplopia and dizziness as the primary
clinical picture, seven days after a booster vaccination with the
ChAdOx1-S (Oxford/AstraZeneca) COVID-19 vaccine.
Uterine artery embolization (UAE) compared with myomectomy for the management of uterine fibroids: a systematic review and meta-analysis
Authors: Williams Emily , Walker Stephen , Quenby Siobhan , Odendaal Joshua
Published: June 2022

Background Uterine artery embolization (UAE) and myomectomy are
uterus-sparing treatments for uterine fibroids. Each carries a different
risk and efficacy profile. Despite this there is a lack of direct
comparison between the two techniques making treatment choice decisions
difficult. Objectives To compare the therapeutic efficacy and
complications of UAE versus myomectomy. Search strategy A systematic
search of The Cochrane Library, Medline, and EMBASE databases was
conducted using a pre-defined search strategy. The review was
prospectively registered on PROSPERO (CRD42021259347). Selection
Criteria All randomised controlled trials and cohort studies published
between January 1995 and August 2021 directly comparing UAE and
myomectomy were included. Data Collection and Analysis Meta-synthesis of
raw data was performed using Review Manager 5.4.1 from the Cochrane
Collaboration. A pooled estimate of efficacy was established using a
fixed-effect model. Main results 8 studies were identified. UAE was
associated with lower complication rates (OR 0.56; 95% CI 0.40-0.79),
increased improvement in bleeding (OR 1.61 95% CI 1.07-2.43) and a
shorter total recovery time (7.72 days versus 36.63 days). Whilst
myomectomy was associated with a higher post-procedure quality of life
(mean difference -10.56; 95% CI -15.34 - -5.79) and lower
re-intervention rate (OR 5.16; 95% CI 2.41-11.04). No significant
difference in procedural failure rate was seen (OR 0.67; 95% CI
0.30-1.50). Given concerns with UAE and future fertility limited
post-procedure fertility outcomes were identified. Conclusions: Given
differences in efficacy profiles a personalised approach to treatment
discussions should be maintained. Funding: None Keywords: Uterine artery
embolization, myomectomy, uterine fibroid
COVID-19 CONTACT TRACING AND TRACKING
Authors: Sarumi,  (PhD) Jerry Abayomi , Abdul-Raheem Ibraheem
Published: June 2022

The recent outbreak of COVID-19 has taken the world by surprise, forcing lockdowns and straining public health care systems. COVID-19 is known to be a highly infectious virus, and infected individuals do not initially exhibit symptoms, while some remain asymptomatic. Thus, a non-negligible fraction of the population can, at any given time, be a hidden source of transmissions. In response, many governments have shown great interest in smartphone contact tracing apps that help automate the difficult task of tracing all recent contacts of newly identified infected individuals. However, tracing apps have generated much discussion around their key attributes, including system architecture, data management, privacy, security, proximity estimation, and attack vulnerability. The use of Covid-19 contact tracing applications is close to be unheard of in Nigeria. We are far behind in leveraging on mobile app technology to combat the continued spread of this deadly virus. This project proposes a mobile app solution that provides adequate information to the contacted victims and as well warns the non-contacted of the dangers of leaving home without their kits. KEYWORDS: Covid-19, covid-19 contact tracing, contact tracing apps, coronavirus, mobile app, covid-19 alert.
Comparison of the Usability, Accuracy, Preference, and Satisfaction of Three Once-Weekly Glucagon-Like Peptide 1 Receptor Agonist Pen Devices in People With Type 2 Diabetes
Authors: Wettergreen Sara A. , Stewart Morgan P. , Kennedy Katelyn , Trujillo Jennifer M.
Published: June 2022

Aim

This study’s aim was to compare the time and accuracy of use and participants’ satisfaction and preferences with pen devices for the once-weekly glucagon-like peptide 1 (GLP-1) receptor agonists dulaglutide, exenatide XR BCise, and semaglutide.

Materials and methods

In this triple crossover, open-label, simulated injection study, GLP-1 receptor agonist pen devices were compared, with time and accuracy of use and participants’ satisfaction and preferences as primary outcomes. Participants had type 2 diabetes and were naive to GLP-1 receptor agonist therapy. Participants watched instructional videos for each device, demonstrated administration, and then provided feedback after each demonstration. Investigators tracked errors and omissions of demonstration steps for accuracy and time. Differences across devices were compared using univariate mixed models, adjusting for multiple comparisons.

Results

Of the 60 participants, 50% were male, a majority (65%) were Caucasian, and most (65%) had adequate health literacy. Participants rated the dulaglutide device easier to use than those of exenatide XR BCise or semaglutide (P <0.001 for each). Participants expressed greater satisfaction with the dulaglutide device compared with those of exenatide XR BCise or semaglutide (P <0.01 for each). Most participants (75%) preferred the dulaglutide device overall; however, many participants (61%) preferred the size and portability of the semaglutide device. The dulaglutide device took less time to use than the exenatide XR BCise or semaglutide devices (69 vs. 126 and 146 seconds, respectively; P <0.001 for each). Participants were less accurate when using the dulaglutide device.

Conclusion

Most participants preferred the dulaglutide device. The dulaglutide device took the least amount of time to demonstrate; however, demonstration accuracy was lower.
Kant e a ciência da consciência
Authors: Alves Marco Aurélio Sousa , Ramos João César
Published: June 2022

Immanuel Kant é um autor que cobriu muitos assuntos, o que torna sua filosofia útil para diversas áreas, dentro e fora do escopo filosófico. A filosofia da mente não é exceção. A filosofia transcendental kantiana pode ter variadas aplicações no debate contemporâneo sobre o estatuto epistêmico e ontológico da mente. O presente trabalho tem por objetivo investigar algumas dessas aplicações, fundamentalmente a partir da Crítica da Razão Pura. Adotaremos uma interpretação um tanto livre dos escritos kantianos, visando menos uma contribuição exegética rigorosa e mais uma apropriação profícua para os problemas atuais da filosofia da mente.
Cultural antropophagy today: a semiotic approach to Oswald de Andrade’s theory of culture
Authors: Baiardi Daniel Cerqueira
Published: June 2022

Close to the centenary of the Modern Art Week, this paper explores the scenario where sign studies in Brazil found its première. It pays attention to relations of some of these pioneers in semiotics with communities not solely of scholars, but also of vanguard artists, critics and other members of the intelligentsia. Oswald de Andrade reclaims some semiotic features of Tupinambás’s martial rituals to develop the notion of Cultural Antropophagy (C. A.). Supported by the methodological framework of C. S. Peirce and elements from semiotics of culture, this study explores the dialogic situation between the national “spirit” [Volkgeist] and the foreign cultures. According to B. Schnaiderman (1979), the development of semiotic studies in Russia do not as expected begins from division of other scientific programs, but from artistic vanguards and literary movements. Peirce (1931-58) in his writings about Philosophy of Science stressed many times about the social character of scientific activity. Probably endorsed by an evolutionary and semiotic criteria Peirce already had pointed out that science can flourish from other kind of cultural phenomena. Indeed, the analysis focuses Andrade’s Modernist ideas as contributions to awake a kind of “semiotic consciousness” in Brazil. I will argue that the developed idea of C. A. not just worked as the poetic motto of Brazilian Modernists but also as a key concept to an original metacultural theory and a strong factor to the development of sign studies at universities in the State of São Paulo.
A interpretação neopragmatista de Richard Rorty sobre o pensamento político de Michel Foucault: um ironista liberal inconcluso
Authors: Silva Heraldo Aparecido , Alencar Bruno Araújo
Published: June 2022

Esse trabalho tem por objetivo evidenciar a compreensão que Richard Rorty (1931-2007), tem do pensamento político Michel Foucault (1926-1984). Inicialmente, apresentaremos o incessante desejo por autocriação que o neopragmatista observa no filósofo francês, um que seria uma forma de se constituir livremente em contraponto às práticas normativas do poder ao longo dos tempos, o que para Rorty, é plausível, mas aponta que Foucault parece esquecer dos desejos por uma comunidade mais solidária, o caracterizando como adepto à cultural Left (Esquerda cultural), em face aos desejos privados, o que seria cruel, e que o filósofo norte-americano não concorda. Rorty mostra que Foucault só tenciona a figura do ironista, aquele que almeja a perfeição privada e tem como a coisa mais importante que os sujeitos podem fazer, contudo, esquece os desejos do liberal, um que diz que a solidariedade humana é algo que deve ser privilegiado para evitar a crueldade, e nesse caso, na conduta política. Nosso trabalho conta com o aporte teórico de Rorty (1998; 2000; 2005; 2007), Foucault (2010; 2014; 2017), Kumar (2005), Malecki (2011), dentre outros. Nosso estudo indica que a visão política que Rorty tem de Foucault é antagônica, já que observa contribuições e distorções, mostrando como o biopoder foi importante para que os sujeitos observassem no passado e presente como são frutos de eixos normativos em meio à política, porém, acaba não mostrando como poderíamos nos livrar dessa crueldade em um futuro, alcançando os desejos de uma comunidade mais humana, idealizando os desejos do ironista liberal.
Aspectos pragmáticos de uma concepção semântica: reflexões sobre as consequências de uma abordagem normativa da semântica
Authors: Vollet Lucas Ribeiro
Published: June 2022

Queremos explorar nesse artigo as características de uma semântica prescritiva e a sua utilidade para resolver problemas pragmáticos de verdade, tanto analíticos como sintéticos. Iremos avançar pelo seguinte caminho: 1. argumentando sobre as limitações de uma semântica não prescritiva e puramente extensional, fundada na predição de fórmulas de um sistema de linguagem-objeto; e 2. projetando as vantagens de uma teoria que possa regular pragmaticamente os esquemas de sentido, para enriquecer nossos instrumentos de significação e produção de consenso com os resultados da inovação científica e da interação entre línguas diferentes. Os dois autores que usamos para exibir esse caminho foram Alfred Tarski, Rudolph, Carnap mais Robert Brandom e C.I Lewis. Os primeiros para uma exposição da semântica formal e seus limites; os segundos para uma exposição de uma teoria intensional e prescritiva e suas vantagens pragmáticas para regular a predição de novas verdades e sua adaptação às antigas.
Linguistic pragmatism in Dewey: a unified conception of mind, thought and language
Authors: Da Silva Jorge Francisco , Efken Karl Heinz
Published: June 2022

According to Stout (2002), Peirce invented pragmatism, James united the world of human experience and that of language and Dewey transformed pragmatism into an instrument of social, cultural progress and democratic awareness. This article analyses the views of language in Dewey and establishes their links with key concepts within his instrumental pragmatism. We begin by examining his theory of language that brings together the concepts of thought and language and explores the body as the origin of   meaning. We analyse his conceptions of communicative action and highlight the role of language in the development of his theory of investigation. Finally, we appreciate the connections between his concept of warranted assertibility, social responsibility and the ethical implications of discourse.
Mario Pedrosa
Authors: Bompuis Catherine
Published: June 2022

Dissociar a atividade política de Mário Pedrosa de seu engajamento com a arte seria não perceber os princípios que guiaram sua vida, como se as inovações artísticas do período do pós-guerra não permitissem a associação destes dois campos. Pedrosa nunca abandonou seu projeto de diminuir “a distância enorme que vai das coisas resolvidas no plano mental ao plano moral da ação. O objetivo deste ensaio não é retraçar a carreira política de Mário Pedrosa, mas entender seu engajamento intelectual na arte e na política. Seus pensamentos e ações a serviço da revolução e em nome de um ideal evoluíram ao longo de sua vida e se tornaram uma parte integral de sua personalidade. A sensibilidade se tornou, assim, a condição necessária para mudar o mundo.
pensamento de Mário Pedrosa sobre museus
Authors: Alves Cauê
Published: June 2022

O presente artigo aborda os projetos de museus que Mário Pedrosa esteve envolvido ao longo de sua vida. Desde o MAM do Rio de Janeiro, do MAM São Paulo, das ideias para um museu na nova capital federal, passando pelo Museu da Solidariedade Salvador Allende, em Santiago durante o seu exílio, até o projeto do Museu das Origens. Entre as décadas de 1950 e 1970, Pedrosa elaborou uma reflexão valiosa e os desdobramentos de suas proposições permanecem relevantes para o debate atual sobre museus. Numa época em que avança o desmonte do campo institucional da cultura, a reflexão de Pedrosa continua abrindo possibilidades para as discussões sobre o futuro dos museus.
MARIO PEDROSA E A CISAC
Authors: Cofré Cubillos Claudia , Quezada Yáñez Lucy , González Castro Francisco
Published: June 2022

La experiencia de Mário Pedrosa como creador del Comité Internacional de Solidaridad Artística con Chile (CISAC) forjó toda una red de afectos, manifestaciones artística y acciones políticas, donde fue clave impulsor del proceso y articulador de una trama que operó bajo los mismos principios que promovió: la solidaridad, la afectividad y la gratuidad de un apoyo desinteresado. El presente artículo nace principalmente de la sistematización y el abordaje crítico de las cartas de Pedrosa con los miembros del CISAC y artistas del mundo. Con este examen buscamos dar la debida relevancia al rol de Mário Pedrosa, en tanto fue un intelectual trascendente en el contexto latinoamericano, instalando debates y reflexiones que permearon su labor a cargo del CISAC. Creemos que el proceder del CISAC y de Pedrosa se presentan con una potencia inusitada, es por ello que las reflexiones que planteamos abren posibilidades de nuevas articulaciones en nuestro presente.
Motocicletas no trânsito brasileiro:
Authors: Ribeiro-Júnior Marcelo Augusto Fontenelle
Published: June 2022

Editorial sobre o artigo publicado neste número:
Santos MM, Oliveira AJCN, Rodrigues JMS. Lesões e padrão das vítimas em acidentes de trânsito com motocicletas atendidas em uma unidade regional de emergência. Rev Fac Ciênc Méd Sorocaba. 2020;22(4):151-5. https://doi.org/10.23925/1984-4840.2020v22i4a4
Lesões e padrão das vítimas de acidentes de trânsito com motocicletas atendidas em uma unidade regional de emergência
Authors: Santos Mariana Machado , Campi Nunes de Oliveira Ana Júlia , Da Silva Rodrigues José Mauro
Published: June 2022

Objetivos: Caracterizar as vítimas de acidentes com motocicletas atendidas na Unidade Regional de Emergência e descrever suas lesões. Métodos: Estudo observacional e descritivo. Nos períodos de agosto a dezembro de 2019 e junho a agosto de 2020, foram analisados os dados demográficos, o mecanismo do trauma, a localização e a gravidade das lesões e o prognóstico dos pacientes atendidos em uma Unidade Regional de Emergência. Foram aplicados índices de trauma (Escore de Trauma Revisado e Índice de Gravidade da Lesão) para gravidade e prognóstico. Todos os dados foram anotados em fichas padronizadas e avaliados estatisticamente. Resultados: Dos 98 casos analisados, 78% eram do sexo masculino, com idade média de 31 anos. O mecanismo do trauma mais frequente foi motocicleta versus veículo automotor, representando 57,1% dos casos, seguido de queda da motocicleta, com 27,6%. As lesões mais frequentes foram as escoriações (60,4%), seguidas das fraturas (23,1%). Os membros inferiores foram os locais de maior acometimento (40,3%). O Índice de Gravidade da Lesão variou de 0 a 11, com moda de 1, e 97,9% das vítimas apresentaram Escore de Trauma Revisado igual a 7,8, com probabilidade de sobrevida de 98,8%. Conclusão: Houve predomínio de jovens do sexo masculino, com lesões de baixa gravidade. Os locais mais acometidos foram os membros inferiores, em sua maioria com escoriações. Mesmo com baixa gravidade e probabilidade de sobrevida elevada, essas lesões podem provocar longos períodos de incapacidade laboral e provocar custos para o sistema de saúde, demonstrando a necessidade de ações para a prevenção desses eventos.
Economia compartilhada e precarização do trabalho
Authors: Cohen Lucas Marques
Published: June 2022

O presente ensaio busca analisar, por meio de referências bibliográficas distintas, a relação entre o modelo de operação de empresas-aplicativos, tais como o Airbnb, Ifood, Getninja e a Uber, com uma nova categoria das ciências econômicas, a economia compartilhada. Comparando autores centrais na formulação desta categoria com outros pesquisadores chaves para a compreensão das novas morfologias do trabalho, buscaremos debater se, de fato, a economia compartilhada é uma alternativa ao hiperconsumo moderno e quais os impactos do modelo de funcionamento destas empresas à vida de seus trabalhadores-consumidores.
Enterococcus spp. in gut microbiota of patients with pulmonary tuberculosis
Authors: Otdushkina L. Yu. , Zakharova Yu. V. , Kholodov A. A. , Levanova L. A. , Pyanzova T. V. , Markovskaya A. A.
Published: June 2022

Aim. To defne the role of Enterococcus spp. in the gut microbiota ensemble in patients with pulmonary tuberculosis. Materials and

Methods. Inoculation of intestinal cultures was performed in 64 patients with multidrug-resistant tuberculosis before the specific therapy (30 patients and 55 strains) and after 1 month of the treatment (34 patients and 63 strains). We then assessed the production of haemolysins, gelatinase, phospholipase, adhesion factors, and organic acids.

Results. A high prevalence of intestinal dysbiosis (66.7%) were detected in patients before the start of anti-tuberculosis therapy. Specifc treatment was associated with a decrease in Lactobacillus spp. along with an increase in C. perfringens and Candida spp. titers as well as with higher prevalence of E. coli lac. Before the treatment, Enterococcus spp. showed pronounced adhesion properties, providing colonization of the intestinal mucosa in titers of 6 (4; 7) lg CFU/g, although not producing invasion enzymes. Upon the 1 month of anti-tuberculosis treatment, adhesion capability reduced and 36% of the strains were low-adhesive. An increase of lipase-producing strains to 18% suggested the adaptation of Enterococcus spp. to a high content of lipids and fatty acids in the intestine.

Conclusion. In patients with pulmonary tuberculosis having high prevalence of intestinal dysbiosis, Enterococcus spp. are frequent symbionts well integrated into the gut microbiota.
Hormonal and immunological features of women with cervical insuffciency
Authors: Beglov D. E. , Artymuk N. V. , Novikova O. N.
Published: June 2022

Aim. To determine the level of estradiol, progesterone, IgA and IgG to these hormones, and IgA/IgG to benzo[a]pyrene in women with cervical weakness.

Materials and Methods. We retrospectively analysed case histories of 200 women, including 100 patients with cervical weakness defned by an ultrasound examination at 18-21 weeks of gestation and 100 patients without cervical weakness. Serum estradiol, progesterone, IgA and IgG to these hormones, and IgA/IgG to benzo[a]pyrene were measured at 18-21 weeks of gestation using enzyme-linked immunosorbent assay.

Results. Patients with cervical weakness had a higher level of serum estradiol [12477 (1000; 31600) pg/mL], IgA to progesterone [2.15 (0.6; 8.3) a.u.] and benzo[a]pyrene [4.74 (0.4; 13.9) a.u.], IgG to estradiol [8.64 (1.2; 23.5) a.u.], progesterone [5.29 (0.2; 20.1) a.u.], and benzo[a] pyrene [11.89 (1.1; 28.5) a.u.] as compared with those without [10946 (2999; 19480) pg/mL, p = 0.034]; [1.42 (0.6; 2.6) a.u., p = 0.034]; [3.22 (0.7; 5.7) a.u., p = 0.032]; [4.78 (0.7; 8.7) a.u., p < 0.0001]; [2.55 (0.2; 5.1) a.u., p < 0.0001]; [4.72 (0.4; 10.1) a.u., p < 0.0001]. An association between the preterm birth and levels of IgA to progesterone (p = 0.00017) and benzo[a]pyrene (p = 0.0003) was established.

Conclusion. Patients with cervical weakness were characterized by higher levels of IgA and IgG to estradiol, progesterone, and benzo[a]pyrene; notably, increased IgA to progesterone and benzo[a] pyrene correlated with a higher risk of preterm birth.
Modern Methods of Patients’ Examination with Traumatic Jaw Injuries
Authors: Tymofieiev Oleksii , Havlytiuk Diana , Ripa Viktoriia , Sokoliuk Marta , Kolisnichenko Lesia
Published: June 2022

Purpose: To determine the possibility of using cytological methods for examining prints taken from the mucous membrane of the alveolar process of a jaw in the area of the bone injury, to determine the effectiveness of the treatment of patients with jaw fractures.
Materials and Methods: We examined 43 patients with jaw fractures. All patients were divided into the following observation groups: group 1 – 19 patients with fractures of the maxilla; group 2 – 24 patients with fractures of the mandible. As a control group served 27 practically healthy people.
Results and Discussion: For patients with post-traumatic complications, it was characteristic that on the 3-4th day after the injury (with early purulent complications) there was an increase in the studied parameters by 1.5-2 times, and similarly on the 7-8th day of treatment – with late purulent complications (post-traumatic osteomyelitis). The normalization of these indicators in patients with developed complications occurred only after the complete elimination of inflammatory phenomena both in the bone tissue and soft tissues.
Conclusions: The study of cytological and cytochemical parameters in prints taken from the mucous membrane of the alveolar process in the area of the fracture allows both to determine the effectiveness of the treatment and to predict the course of the disease.
Implementasi DBSCAN dalam Clustering Data Minat Mahasiswa Setelah Pandemi Covid19
Authors: Kristianto Ariel
Published: June 2022

Pandemi Covid19 mengubah pola kehidupan manusia, termasuk dunia pendidikan yang juga ikut terkena imbas dari pandemi ini. Proses Kegiatan Belajar Mengajar (KBM) di sekolah maupun pendidikan tinggi harus beradaptasi dengan kondisi saat pandemi ini. Proses KBM terpaksa harus dilaksanakan melalui media daring atau online. Hal ini dilakukan demi memutus rantai penyebaran virus Covid19. Penelitian ini bertujuan mencari minat mahasiswa dalam metode perkuliahan setelah pandemi ini usai, apakah dilaksanakan secara daring, luring ataupun gabungan (hybrid). Variabel yang digunakan dalam penelititan ini antara lain usia, jenis kelamin, semester, IPK dan segi keilmuan (Eksakta dan Non-Eksakta). Dalam proses mencari variabel penentu tersebut digunakan algoritma DBSCAN untuk mengelompokkan variabel yang berpengaruh dalam minat metode perkuliahan mahasiswa tersebut. Dari 385 responden didapatkan hasil faktor penentu mahsiswa dalam memilih minat metode perkuliahan adalah semester, IPK, dan kelompok ilmu (Eksakta atau Non-Eksakta) sementara usia dan jenis kelamin tidak mempengaruhi pemilihan minat metode perkuliahan mahasiswa tersebut.
Influence of watershed land use on water quality in the state of Santa Catarina, Brazil
Authors: Vieira Isabel C.B. , Ribeiro Eduardo A.W.
Published: June 2022

The inappropriate use of water resources by human actions compromises the balance between natural and anthropogenic factors. In this study, exploratory and field research were conducted with a scope of quantifying, based on satellite imaging, the use and occupation of land on the banks of the Itajaí-Açu River, the largest watercourse in the Itajaí River Basin, located in the State of Santa Catarina, Brazil. Five sampling points were allocated along the river at different times of the year to analyze water quality using chemical and biological indicators. The characterization of land use and occupation was carried out with Sentinel-2B satellite images at 10m resolution and QGIS software. Version 3.6.3 of the R Software was used to consolidate the data. The land use was categorized into several classes, the most representative of which was vegetation, which presented coverage of 34.42%, followed by the pastures and open fields class, with 27.83%, agriculture, with 18.18%, and urban areas, with 16.59% coverage. Our study showed that 62.6% of the river’s base was affected by anthropogenic influence, characterizing an environment severely altered from its normal state. The results obtained in the statistical analysis revealed a directional correlation between land use and water quality, thus indicating that cities on the banks of watercourses are major sources of potential contaminants. Among the classes of land use, the presence of vegetation along the riverside territory attenuated part of the load of pollutants launched into the Itajaí-Açu River. This finding highlights the importance of conserving the vegetation alongside the river to maintain water quality and, consequently, preserve the ecosystem’s biota.
Transformed Wetlands and Urban Resilience: a Case Study From Bellanwila – Attidiya Wetland Sanctuary, Sri Lanka
Authors: Gayani Munagamage S. , Wickramasinghe Deepth D. , Dahanayake Harsha D. , Weerasinghe Yugani N.
Published: June 2022

Urbanization is a major issue that threatens natural habitats. However, carefully planned anthropogenic activities give the opportunity to transform urban natural habitats to offer new services to cities. In this study, we assessed the impact of land-use conversions on the spatial status of Bellanwila - Attidiya wetland sanctuary in the Colombo district, Sri Lanka.  The Bellanwila - Attidiya wetland provides many ecosystem services but is highly vulnerable to the rapid land use and land cover changes that comes with urbanization. Multi-temporal remote sensing images were analyzed for the years 2005, 2009, and 2015 to study the changes in land use/land cover features of the wetland. The social perception of the ecosystem services was assessed by conducting semi-structured interviews with the residents. During the study period, parts of the wetland had been transformed into residential areas (10.1%) and open water systems (8.6%). Urban expansion and the construction of a storm water management system were found to be the main causes for these changes. The community perception revealed that the wetland has deteriorated, and that the ecosystem services had been altered due to the land use/land cover changes. The anthropogenic transformation of  part of the wetland into a flood retention area and the addition of infrastructure for recreational purposes have added value to the wetland complex and therefore opportunities for new ecosystem services have emerged. Our findings shed light on the need for inclusive urban planning mainstreaming community perceptions. It also highlights the benefits of transforming urban spaces into anthropogenic landscapes that blends with nature to offer ecosystem services and enhance community resilience.
RELIGION INTERPRETATIONS OF SANITARY
Authors: Arifin Zainal
Published: June 2022

The study of Piwko showed that the greater the religiosity in Islam, the lower the acceptance of pandemic restrictions. Is this issue true? On the other hand, the Quran Surah al-Mâidah (5): 6 became the inspiration for a long study by the commentators in the chapter of Taharah in Islamic Law. The object of this paper will examine the COVID 19 issue and the verse from the sanitation side. This paper uses library research, with the approach of Tafseer Maudûi, the tahlîli system, and also inductive and deductive methods. Conclusion, first, cleanliness and purification are part of Islamic teachings and inseparable from faith and love. Second, ablution and ghusl are the cleanliness, and are very healthy from a medical point of view. Third, although tayammum uses earth, it seems less clean, but in fact earth is clean, purify, and it can be used as a health medium. Fourth, the three advantages of taharah. Fifth, to be grateful that Islamic sanitary starts from personal hygiene, maintaining chastity, continues to maintain the sanctity of prayer places, to maintaining environmental cleanliness. The novelties are that sanitary in the Qur'an is not only limited to a global or general strategy, but is also tactically regulated in a more technical and detailed form. The sanctity and cleanliness of mosques and Muslims is proof that they are not part of the COVID 19 cluster. That the greater the religiosity, the higher the acceptance of cleanliness and purification which can limit the pandemic restrictions. As the message of QS al-Mâidah [5]: 6.
Revitalisasi Kebudayaan Melalui Pertunjukan Sawat Untuk Membangun Moderasi Beragama
Authors: Candra Iga Ayu Intan
Published: June 2022

Revitalisasi kebudayaan sebagai upaya menghidupkan kembali budaya yang telah punah atau mengembangkan budaya lokal untuk menemukan potensi serta melestarikan keberadaannya di Maluku dilakukan melalui pelatihan dan pertunjukan Sawat sebagai local wisdom. Penelitian ini mengkaji beberapa aspek-aspek seni yaitu proses revitalisasi  Sawat mahasiswa IAIN Ambon sebagai wujud revitalisasi budaya dan fungsi pertunjukan Sawat dalam membangun nilai moderasi  beragama di IAIN Ambon. Penelitian ini merupakan penelitian deskriptif kualitatif yang mendeskripsikan hasil observasi pada pertunjukan Sawat yang dilakukan mahasiswa IAIN Ambon berdasarkan unsur-unsur seni didalamnya dan nilai yang terbangun sebagai upaya revitalisasi budaya. Pengumpulan data penelitian menggunakan teknik observasi partisipasi. Peneliti melakukan pengamatan terhadap proses latihan dan proses pertunjukan yang dipersiapkan mahasiswa IAIN Ambon dan berpartisipasi dalam proses sampai dengan terjadinya pertunjukan. Pertunjukan Sawat dalam proses revitalisasi kebudayaan terbukti mampu membangun moderasi beragama melalui fungsinya sebagai seni pertunjukan yaitu pembawa atau penyampai  nilai moderasi beragama melalui proses interaksi sosial. Konsep kelembutan dan kerjasama dalam seni diharapkan menjauhkan mahasiswa dari pemikiran ekstrimisme yang saling membeda-bedakan. Sikap moderat dalam Islam berupa toleransi terhadap perbedaan dan keterbukaan menerima keberagaman dapat tumbuh jika individu dapat menerima sesamanya melalui proses sosial.
ANALISIS KEMAMPUAN MENGGUNAKAN TANDA BACA PADA TEKS NARASI PADA SISWA KELAS V SDN 2 PETOBO KECEMATAN PALU SELATAN
Authors: Ferdiawan
Published: June 2022

Penelitian ini dilakukan merupakan analisis terhadap penggunaan tanda baca , khususnya bentuk penggunaan tanda baca titik, tanda baca koma, dan tanda baca tanya. Bentuk penggunaan tanda baca tersebut dianalisis dari tek narasi yang dikerjakan oleh siswa kelas V SDN 2 Petobo kecematan Palu selatan. Tujuan dari penelitian ini untuk medeskribsikan bentuk penggunaan tanda baca titik, tanda baca koma, dan tanda baca tanya pada teks narasi yang dikerjakan oleh  siswa dan juga merupakan bentuk penggambaran kemampuan siswa kelas V SDN 2 Petobo dalam penggunaaan tanda baca pada teks narasi. Setelah semua tahap penelitian ini dilaksanakan , hasil dari penelitian  yaitu : pertama, berdasark Dari hasil tes yang dilakukan penulis bahwa terdapat 7 siswa  telah memperoleh skor diatas KKM dengan perolehan skor tertinggi 26 dan sebanyak 17 siswa lainya memperoleh skor dibawah KKM dengan skor yang diraih yang terendah 7, dan Dari hasil tes kedua yang dilakukan penulis bahwa, terdapat 14 siswa  telah memperoleh skor diatas KKM dengan perolehan skor tertinggi 28 dan sebanyak 10 siswa lainya memperoleh skor dibawah KKM dengan skor yang diraih yang terendah 15. kedua, bentuk penggunaan tanda baca titik yang ditemukan dalam lembar tugas melengkapi teks narasi 1. dipakai diakhir kalimat pernyataan. 2. dipakai dipertengahan kalimat. 3. dipakai diakhir kalimat tanya., 4 dipakai diakhir kalimat seruan . ketiga, bentuk penggunaan tanda baca koma yaitu: 1. dioakai diakhir kalimat pernyataan, 2. dipakai dipertengahan kalimat. Keemapat bentuk penggunaan tanda baca tanya yaitu: 1. dipakai diakhir kalimat pernyataan.
Strategi Pengelolaan Likuiditas Pada Bank Syariah Indonesia
Authors: Liana Nova , Muhammad Rafi roykhan  , Kharis Fadlullah Hana
Published: June 2022

Pengelolaan likuiditas merupakan faktor yang sangat penting di Perusahaan Perbankan. Meskipun demikian, pngelolaan likuiditas di masa saat ini cukup sulit dilakukan, Namun mengingat hal itu masing-masing Perusahaan Perbankan memiliki strategi agar perusahaan perbankan dapat menjaga nilai likuiditasnya. Melihat fenomena tersebut Penelitian ini bertujuan untuk mengetahui pengelolaan likuiditas dan alat likuid yang digunakan untuk mempertahankan likuiditas pada lembaga keuangan Bank Syariah Indonesia. Penelitian ini menggunakan metode penelitian kualitatif deskriptif dengan pendekatan fenomonologi. Pengambilan data pada penelitian ini melalui wawancara secara langsung dengan informan karyawan dan nasabah Bank Syariah Indonesia. Hasil dari penelitian ini kita dapat mengetahui strategi pengelolaan likuiditas Bank Syariah Indonesia, strategi yang di pakai oleh Bank Syariah Indonesia dalam pengelolaan likuiditasnya ialah konsep persediaan, arus pendapatan, konsep arus, LDR (loan to deposite ratio), cash ratio, namun Bank Syariah Indonesia cabang Kudus ini memiliki Strategi khusus dan yang sering digunakan ialah strategi alokasi dana. Maka, rekomendasi dalam penelitian selanjutnya agar lebih mebahas secara lebih detail terkait kelebihan dan juga kekurangan dalam masing-masing startegi yang diterapkan.

Katakunci:

Bank Syariah_1, Likuiditas_2,

Strategi Pengelolaan_3, Manajemen_4,
Analisis Tingkat Kesehatan Unit Usaha Syariah Dalam Menghapus Tuntutan Spin Off (Menggunakan Metode RGEC)
Authors: Hamidah Innaroh , Siti Milasari  , Karen Ainiyya  , Ilda Alfiah  , Sahrul Noval  , Rafika rahmawati
Published: June 2022

Penelitian ini bertujuan untuk mengukur tingkat kesehatan Unit Usaha Syariah dengan menggunakan metode RGEC. Berdasarkan dengan Undang-Undang Nomor 21 tahun 2008 tentang Perbankan Syariah, Bank wajib memelihara tingkat kesehatannya. Bank yang sehat adalah bank yang dapat menjalankan tugasnya dengan baik, sehingga penting bagi Unit Usaha Syariah untuk menjaga dan memelihara kepercayaan Masyarakat. Dalam menilai tingkat kesehatan bank dapat dilihat dengan menggunakan metode RGEC (Risk Profile, Good Corporate Governance, Earning, dan Capital) yaitu metode yang paling banyak mempengaruhi kinerja keuangan bank. Teknik analisis data dalam penelitian ini adalah deskriptif kuantitatif dengan menghitung rasio keuangan menggunakan metode RGEC. Hasil penelitian ini menunjukkan bahwa Unit Usaha Syariah memiliki kategori tingkat kesehatan yang sehat pada tahun 2020-2021, Unit Usaha Syariah tersebut diantaranya PT. Bank Tabungan Negara Syariah, PT. Bank Danamon Indonesia, PT. Bank Permata, PT. Bank OCBC NISP, dan PT. Bank Sinarmas.
Analisis Minat Nasabah Non- Muslim Untuk Melakukan Pembiayaan Pada PT. BPRS Gebu Prima Medan
Authors: Rifani Anggraini, Nurul Inayah  , Nurul Inayah
Published: June 2022

Bank syariah merupakan bank yang menjalankan kegiatan usaha berdasarkan prinsip syariah atau prinsip hukum islam. Semakin berkembangnya zaman bank syariah tidak hanya memiliki nasabah dari kalangan umat muslim tetapi juga masyarakat non muslim yang mulai berkontribusi untuk menjadi nasabah bank syariah, seperti PT. BPRS Gebu Prima Medan juga memiliki nasabah aktif yang non muslim. Seperti yang diketahui non muslim yaitu orang yang mempunyai kenyakinan yang berbeda dengan agama islam. PT. BPRS Gebu Prima Medan adalah bank yang melaksanakan kegiatan usaha berdasarkan prinsip syariah yang dalam kegiatannya tidak memberikan jasa dalam lalu lintas pembayaran. Jenis penelitian ini merupakan penelitian lapangan, karena data yang diperoleh dari hasil pengamatan langsung di PT. BPRS Gebu Prima Medan. Penelitian ini menggunakan metode kualitatif. Sumber data dari penelitian ini yaitu data primer dan data sekunder. Data primer yang digunakan dalam penelitian ini adalah data yang berupa gambaran tentang faktor – faktor apa saja yang memengaruhi non muslim menjadi nasabah. data sekunder yang digunakan dalam penelitian ini yaitu buku – buku yang berkaitan dengan permasalahan yang peneliti ambil.  dari yang diteliti penulis menemukan terdapat dua faktor, yaitu faktor internal dan faktor eksternal. Faktor internal yaitu pekerjaan, motivasi. Sedangkan faktor eksternal yaitu, promosi, pelayanan, lokasi, dan tingkat sosial. Berdasarkan hasil penelitian maka dari variable faktor internal dan eksternal yang diteliti, dan variable yang dominan mempengaruhi minat nasabah non muslim menjadi nasabah PT. BPRS Gebu Prima Medan yaitu variable faktor eksternal, seperti: promosi, pelayanan dan lokasi yang mendominan. Semakin baik promosi, pelayanan yang diberikan oleh pihak bank maka minat nasabah non muslim menjadi nasabah di bank syariah semakin tinggi.
EKSPLORASI ETNOMATEMATIKA DAN ETNOSAINS (ETNOMATHSAINS) PADA BATIK BOMBA
Authors: WARLI DWI , Musa Suryani
Published: June 2022

Kehadiran inovasi pembelajaran sangat diperlukan agar pembelajaran lebih menyenangkan sebab kita berada pada era disrupsi yang menekankan inovasi-inovasi dan kreatifitas baru. Satu diantaranya dengan mengaitkan budaya lokal dalam pembelajaran. Ethnomathscience merupakan kolaborasi antara etnomatematika dan etnosains, sehingga budaya lokal diintegrasikan secara sinergis. Konsep matematika dan sains kadang muncul secara alamiah melalui budaya masyarakat tertentu, pengetahuan dan pandangan suku, kelompok masyarakat atau individu tertentu. Tujuan penelitian ini untuk 1) mendeskripsikan konsep-konsep matematika dan sains yang terdapat pada motif batik Bomba, 2) memberikan pemahaman tentang etnomathscience, 3) memberikan keterampilan bagi guru dalam menganalisis materi ajar yang dapat diintegrasikan dengan budaya lokal kota Palu. Dalam penelitian ini, peneliti menggunakan penelitian kualitatif dengan pendekatan etnografi. Instrumen dalam penelitian ini adalah human instrument, data dikumpulkan melalui wawancara, observasi, dokumentasi, dan pengumpulan data pustaka. Teknik analisis data dilakukan dengan reduksi data, penyajian, analisis serta pemaparan data. Hasil penelitian ini berupa konsep-konsep matematika dan sains yang terdapat pada motif batik Bomba seperti garis lurus, garis lengkung, garis sejajar, titik, sudut, persegi panjang, segitiga, lingkaran, jajargenjang dan konsep kesebangunan. Serta konsep sains yang terdapat pada batik Bomba adalah upaya pelestarian sumber daya alam. Konsep matematika dan sains yang terdapat motif batik Bomba tersebut dapat dimanfaatkan untuk memperkenalkan dan memahami konsep matematika dan IPA melalui budaya lokal.
ANALISIS KESALAHAN MAHASISWA DALAM MENYELESAIKAN SOAL FISIKA MATERI FLUIDA DINAMIS
Authors: Rahmawaty Rahmawaty
Published: June 2022

Penelitian ini bertujuan untuk mendiskripsikan kesalahan-kesalahan yang dilakukan mahasiswa dalam menyelesaikan soal fisika pada materi Fluida Dinamis. Penelitian dilakukan di UIN Datokarama Palu. Subjek pada penelitian ini adalah mahasiswa Jurusan PGMI FTIK smester 4 kelas PGMI 1 tahun ajaran 2022/2023 yang terdiri dari 6 orang mahasiswa yang dipilih dari 27 orang mahasiswa yang telah mengerjakan soal diagnostic. Enam orang tersebut terdiri dari dua orang dengan kemampuan fisika baik, dua orang dengan kemampuan fisika sedang, dan dua orang dengan kemampuan fisika rendah. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan melakukan tes dan wawancara untuk mengumpulkan data. Analisis dilakukan dengan menggunakan empat kesalahan yang dikembangkan oleh Brodie. Berdasarkan hasil penelitian ditemukan bahwa subjek penelitian melakukan kesalahan appropriate error dan partsial insight.
ILEGITIMASI ABORSI OLEH KORBAN PERKOSAAN BERDASARKAN HAK UNTUK HIDUP JANIN
Authors: Sinambela Tanti Agustina , Melatyugra Ninon
Published: June 2022

Artikel ini hendak mendiskusikan keberlakuan hak untuk hidup bagi janin serta mengkritisi Undang-Undang Nomor 36 Tahun 2009 tentang Kesehatan yang memberikan pengecualian aborsi yang dilakukan korban perkosaan yang menyebabkan trauma psikologis. Tesis yang ingin dipertahankan adalah pengecualian aborsi yang dilakukan semata-mata untuk kepentingan korban perkosaan telah melanggar hak hidup bagi janin. Tesis ini menggunakan dasar argumen bahwa hak hidup merupakan hak yang bersifat non-derogable rights (berlaku juga untuk janin) serta personal integrity perempuan tidak bisa menjadi alasan pengecualian yang sah terhadap hak untuk hidup. Dengan demikian, Indonesia sebagai negara yang menjunjung tinggi perlindungan hak asasi manusia, seyogyanya membatalkan norma pengecualian tindakan aborsi sebagaimana diatur dalam Undang-Undang Nomor 36 Tahun 2009 tentang Kesehatan yang telah melanggar hak hidup.
Editorial
Authors: Salerno Sébastien , Fürst Silke , Meißner Mike
Published: June 2022

This special issue of Studies in Communication Sciences (SComS) is dedicated to DACH 21, the first three-country conference on communication science, held on April 7–9, 2021, and hosted by the Department of Communication and Media Research (IKMZ) at the University of Zurich. Titled “#Communication #(R)Evolution. Changing Communication in a Digital Society,” the conference addressed, for instance, structural transformations of the public sphere and how changing media and communication technologies impact politics, culture, news production, media usage, and everyday life (Bachmann, 2021). Accordingly, the 16 research articles in this special issue, written by scholars from Germany, Austria, Switzerland, Denmark, Spain, and Norway, deal with such changes. They also shed a light on how the COVID-19 pandemic has affected the production, dissemi-nation, and usage of news and science-related information. The guest editors, Thomas Zerback, Mark Eisenegger, Thomas N. Friemel, and Mike S. Schäfer organized the review process for this special issue and, in a separate editorial, introduce the contents of the articles chosen. We thank the guest editors and all of the authors for their outstanding work in making this special issue a reality.
Changing the focus in multimedia story production: Experiences from high budget and low budget production settings
Authors: Planer Rosanna , Godulla Alexander , Wolf Cornelia
Published: June 2022

Complex multimedia stories have initially emerged as prestige projects from high budget newsrooms such as The New York Times or the Washington Post; over time, both the practical experiences with the format as well as the developed technological affordances made it possible for smaller, more inexperienced newsrooms to produce complex multimedia stories, too. Within two different studies, we analyzed the production processes in both high budget and low budget settings. In this paper, we contrast the findings of both studies with the goal of abstracting indicators of change and implications for future productions. Based on the abstraction, we suggest changing the focus in multimedia storytelling productions from a product-oriented process toward a more process-oriented production; from a focus on hard production factors such as numbers and personnel to more soft factors such as distributed responsibilities and internal workflows; and from a focus of rather incidental communication toward a more managed communication within the production team. We conclude by deriving further implications for future research as well as journalistic practice and education.