bluuebunny/crossref_metadata_2025 huggingface dataset:
The Linguistic History and the Ideological Inhibitions in Foreign Language Context in the Post-Independence Algeria
Authors: KHELLOUL Soufyane , Benneghrouzi Fatima Zohra
Published: July 2020

The issues addressed in this work concern primarily the linguistic history and the different language policies that have been adopted from independence till today. Through this paper, the author aims to tackle the status of foreign languages in the Algerian educational system and the extent to which English has been promoted on the expanse of French. Henceforth, the higher education reforms and their influence on the process of teaching/learning English as a foreign language. Mainly, this study intends to uncover the ideological inhibitions exercised by the government to model up a citizen meets the requirements that it needs but not the requirements of the 21st century. More specifically, it exposes the trends of the Algerian decision-makers to maintain a position of a particular foreign language –French- over another foreign language, which is English among the Algerian speech community. This study will contribute to the reconsideration of the language policy of the government, the status of English as a foreign language, and the foreign language curricula. Yet, it bears a particular significance to the sociolinguistic situation in Algeria and its relationship to English as a foreign language context. It suggests the importance of promoting English to meet up the escalating waves of globalization.
The relationship of arithmetic as two twin Peano arithmetic(s) and set theory: A new glance from the theory of information
Authors: Penchev Vasil Dinev
Published: July 2020

The paper introduces and utilizes a few new concepts: “nonstandard Peano arithmetic”, “complementary Peano arithmetic”, “Hilbert arithmetic”. They identify the foundations of both mathematics and physics demonstrating the equivalence of the newly introduced Hilbert arithmetic and the separable complex Hilbert space of quantum mechanics in turn underlying physics and all the world. That new both mathematical and physical ground can be recognized as information complemented and generalized by quantum information. A few fundamental mathematical problems of the present such as Fermat’s last theorem, four-color theorem as well as its new-formulated generalization as “four-letter theorem”, Poincaré’s conjecture, “P vs NP” are considered over again, from and within the new-founding conceptual reference frame of information, as illustrations. Simple or crucially simplifying solutions and proofs are demonstrated. The link between the consistent completeness of the system mathematics-physics on the ground of information and all the great mathematical problems of the present (rather than the enumerated ones) is suggested.
Socially-Structured Mobility Networks and School Segregation Dynamics: The Role of Emergent Consideration Sets
Authors: Burdick-Will Julia , Grigg Jeffrey A. , Nerenberg Kiara Millay , connolly faith
Published: July 2020

This study proposes and applies a novel method for empirically evaluating the role of social structure in the school sorting process. We use administrative records from Baltimore City and suburban Baltimore County public elementary schools (2011-2015) to generate a network of schools based on student transfers. We then apply repeated calculations of the Louvian method of community detection to estimate emergent sets of schools that are likely to be considered by similar parents – which we term emergent consideration sets – and use gravity models to explore the role of social structure, demographics, and geography in observed enrollment patterns. We find that our network-derived emergent consideration sets are better defined by structural boundaries than student composition or proficiency alone. Within consideration sets, students tend to avoid schools with relatively higher levels of free- and reduced-price meal eligibility and flock towards schools with higher proficiency levels. School racial composition, however, plays a much smaller role in predicting movement between schools, in part because structural constraints generate racially homogeneous consideration sets. Together, these findings highlight how regional social and geographic organization shapes school segregation processes and the policies used to combat them.
Effectiveness of Using Poly Category Mind Map for Vocabulary Development
Authors: Prabha Thashwinny a/p , Aziz Azlina Abdul
Published: July 2020

Despite learning English formally in primary classrooms, most of the Malaysian primary learners are incapable of conveying their ideas accurately in the target language since they have limited vocabulary. Action research based on the Kemmis and McTaggart Action Research Model was carried out to alleviate the vocabulary learning challenges. Thus, the study aims are to investigate the effects of the Poly Category Mind Map for vocabulary development of third-year students. Thirty students from the third-year suburban school in Mersing, Johor participated in the study. Vocabulary pre-test and post-tests used as the instruments of collecting the data. The results of the post-test at the end of the second cycle showed a significant difference between the mean scores before and after using Poly Category Mind Map to develop vocabulary (p>0.05). The use of Poly Category Mind Mapping helped students in understanding and remembering the words, their meaning, and spelling precisely. The findings concluded that using the features of Poly Category Mind Map, which are the pictures, keywords, and grouping of words aided the students in learning vocabulary. This study hopes to encourage students, teachers, and curriculum designers to integrate Poly Category Mind Mapping strategy in English classrooms. Researchers can also utilise the Poly Category Mind Mapping in learning skills of the English Language such as reading and writing for further studies.
META-ANALYSIS: TYPES OF MEDIA AND CHARACTERISTICS OF PHYSICAL MATERIALS SUITABLE FOR PHYSICS LEARNING MEDIA BASED ON ADOBE FLASH SOFTWARE
Authors: Azis Hasbi , Risma Mutia , Yolanda Sinta , Desnita Desnita , Usmeldi Usmeldi
Published: July 2020

This research aimed to analyze the types of media and the characteristics of physics materials that are suitable for use in the development of physics learning media, using Adobe Flash software. The research uses a meta-analysis method, which is a method for analyzing many of the research that has been done. This research uses secondary data obtained from previous research in the form of journals related to the media using Adobe Flash software for senior high school physics subjects. The journals examined in this research consisted of 20 research articles that developed an adobe flash-based interactive learning media for physics learning in senior high schools. The number of articles reviewed consisted of 3 articles from international journals and 17 articles from national journals. Based on the results of the analysis that has been done, found 13 physics materials obtained from 20 journals analyzed, where the concepts of temperature, heat, and transfer are the most widely used material as content in the development of physics learning media based on Adobe Flash software. While the type of media that is widely used in computer-based learning media.
ANALISA INTERPRETASI POLA ALIRAN AIR BAWAH TANAH KELURAHAN LABUH BARU BARAT KECAMATAN PAYUNG SEKAKI PEKANBARU MENGGUNAKAN METODE GEOLISTRIK KONFIGURASI SCHLUMBERGER
Authors: Krisman Krisman , Julianti Citra Siti Fatimah , M Juandi
Published: July 2020

Underground water is one of the important component sources for human being. Study on interpretation of underground water flow has been carried out using Geoelectric Schlumberger Electrode Configuration in Labuh Baru Barat Village, Payung Sekaki District, Pekanbaru. The range measurement was chosen to be 240 meter. The output of measurement  arecurrent and voltage. The data, then was inputed into software progress and surfer 11. The output of this computer program is a map of underground waterflow  pettern and underground lithology. The results of mapping of the pattern of underground water flow indicate that the direction of water flow from North to South direction, or from Pinang street to Payung Sekaki street. The thickness of the layer start  from the first layer that is 4.05 meters and 5.4 meters is a layer of silt- clay, the second layer is 13.07 meters and 14.3 meters is a layer of mud stone, the third layer is 13.07 meters and 15.2 meters is a layer of sand and alluvial and the fourth layer is 51.1 meters and 79.2 meters is layer of gravel sand.
ANALISA PENGARUH GAYA ELEKTROSTATIK PADA SPEKTRUM PENCITRAAN RESONANSI MAGNETIK (MRI) DALAM JARINGAN BIOLOGI
Authors: Salomo Salomo , Lestari Nova , Hamdi Muhammad
Published: July 2020

A study of magnetic core resonance imaging modeling of biological tissue has been carried out in analyzing the effect of electrostatic forces with computational approach. This analysis aims to look at the effect of electric and magnetic force on the spectrum of breast cancer tissue. Physical parameters were determined using the modeled wave equation with the application of mathematical wolfram software 9. Computational or modeling results obtained 6 variations of the MRI spectrum showing the peak magnitude of the electric and magnetic spectrum changes by varying the resolution and distance. This is evidenced from the maximum resolution range ie the peak of the electric field spectrum at amplitude 25 a.u is at a concentration of 5 ppm. Resolution of spectrum peak medium is at concentration of 3-4 ppm whereas minimum resolution has 4 peak spectrum that is at concentration 1-2 ppm, 2-3ppm, 3-4ppm and 4ppm. the result of MRI spektrum for distance variation resulted in spectrum change, further reduced the distance then the mri spectrum in magnetic and electric field approaching spin 1.
STUDI AWAL RANCANG BANGUN COLORIMETER MENGGUNAKAN SENSOR OPT101 BERBASIS SISTEM ANDROID DENGAN DISPLAY SMARTPHONE
Authors: Putra Habibi , Yulkifli Yulkifli
Published: July 2020

Colorimeter is a color measuring device that is a tool that can distinguish colors based on the value of the output produced. In this study a colorimeter device was made using the OPT101 sensor, an analog sensor based light detector. OPT101 sensor has characteristics if the intensity of light received is getting brighter, the greater the sensor output value and vice versa. Because of the characteristics of the sensor like that, this sensor can be used as a measuring instrument to determine the concentration of a food coloring agent. This study aims to look at investigating the relationship between the concentration value of a dye solution to the OPT101 sensor response value contained in the colorimeter tool. The dyes used are red (metile red) and blue (brilliant blue) with 10 different variations of concentration, with a range of 0.01% -0.1%. After the measurement experiments were carried out on the sample, the results obtained were almost the same as the theory, namely the relationship between the concentration value was inversely proportional to the value of the sensor output. The inverse relationship means that the more concentrated a dye solution is, the more the light intensity penetrates the substance or dims. So that the OPT101 sensor detects a dimmer light source, the sensor output value gets smaller, because the relationship of the sensor output value is directly proportional to the intensity of the received light. Based on the measurements that have been made, the results of sensor response values are obtained for the red sample with a range of data from 276,698 decreasing to 240,762, while for the blue sample from the range 9,828 it decreases to 8.75. The value for the blue sample is much smaller because the blue sample is much thicker than the red sample.
DETEKSI EFEK GEMPABUMI PADA IONOSFER MENGGUNAKAN DATA GNSS
Authors: Santoso Anwar , Muslim Buldan , Fitriyani Siti Inayah
Published: July 2020

Seismic activities such as earthquakes can cause atmospheric and infrared gravitational waves. If the earthquake happens to be strong enough (M> 6 SR), these waves can spread to the ionosphere altitude in the form of atmospheric and infrasonic gravitational waves. The monitoring system of ionospheric wave that associated with earthquakes from network of GNSS data has been much developed in Indonesia by using the sliding Fast Fourier Transform (SFFT) programfor disturbed ionospheric TEC positions. The results of previous studies, differential TEC showed irregular fluctuations in the order of several tens of seconds until to several tens of minutes with average amplitude less than 0.01 TECU. At times the ionospheric is not disturbed (regular), the amplitude can reaching greater than 0.01 TECU. As a case study, in this paper a methodological examination will be conducted on the events of Aceh earthquake on December 26, 2004 (M = 9.2 SR), Tohoku March 11, 2011 (M = 9 SR) and Yogyakarta May 27, 2006 (M = 6.2 SR).
Konsep Pendampingan dalam Struktur Pemerintahan Indonesia: Mengapa Pendamping Lokal Desa Harus Ada?
Authors: Rambe Jenny Yelina , Badaruddin Badaruddin , Kadir Abdul
Published: July 2020

Rural development is a priority of national development program in Indonesia. A number of measures have been taken such as decentralization of authority, capacity building, and budget approach. The most recently used action to accelerate rural development is through the village assistance program. Each village has a local village assistant to optimize the village administration performance and build the village community capacity in the rural development process. This research aims to explore the concept of village assistance program and the role of local village assistants in Batu Layan Village, Padangsidempuan City, North Sumatra Province. This research used qualitative research. The data were obtained through in-depth interviews, library research, and documentation studies. The research results indicated that the concept of village assistance was applied in stages following the governance structure in Indonesia to encourage the realization of the functions and authorities of each government structure in achieving development targets. Village local assistants in this research were able to perform their functions skillfully through a persuasive communication approach based on local values in the local area.
Akses Informasi Literasi Keislaman Rohis di Indonesia: Analisis Konstruksi Keberagamaan
Authors: Dalimunthe Muhammad , Purwaningtyas Franindya
Published: July 2020

This research was conducted in three major cities in Indonesia (Medan, Yogyakarta, and Makassar). The choice of location was based on the representation of high schools in Indonesia. These cities have different Rohis characteristics from other cities. This study aims to know access to Islamic information literacy among Rohis activists in Indonesia. Rohis became an important pillar in shaping the Islamic model in public schools because it was considered as a reference for Islam in schools. The research model used is qualitative, by analyzing in-depth data through the point of view of the informant through the FGD. The results showed that of the three cities sampled had different characteristics of Islamic information access. The cities of Medan and Makassar are more dominated by social media such as Instagram and Youtube. Also, Makassar has a popular local figure who is a source of reference. The city of Yogyakarta is more dominantly influenced by educational institutions, religious organizations, and local religious leaders that can be accessed directly. Models of access to information construct Rohis religious diversity and their views of different countries and people so that they tend to follow the religious model of the figures and sources of information that are most often accessed and consumed.
Faktor Kemenangan Partai Barisan Nasional Malaysia dalam Pemilu Selama 60 Tahun (1957-2018)
Authors: Masitoh Dewi
Published: July 2020

This research aims to analyze the National Front Partyâ€™s (Barisan Nasional) strategies in carrying out their function as a political party in Malaysia. The problem focused on this paper is the victory factors of the Malaysian National Front Party in the Election for 60 years. To approach this problem, the theoretical framework will be used in this paper from Prof. Miriam Budiardjoâ€™s concept, that the concept of a political party. The concept of political party is a tools and instruments for the people to participate and contribute in managing a country. Data from this paper has collected through secondary data and literature review and analyzed qualitatively. This research concluded that there were several factors that led to the National Front always winning in the election for 60 years, they are: First, the polarization and fragmentation politics in Malaysia, itâ€™s called by Bumiputera policy, income gap and the Chinese Tsunami. Second, the influence of the New Economic Policy (NEP) as an affirmative action effort and there is a mix and match policy. Third, Gerrymandering and delineation in the form of an electoral system that is designed, so that the National Front always wins. Fourth, the instability and weakness of the Pakatan Rakyat as coalition opposition party.
Faktor - Faktor Penyebab Kudeta Terhadap Kekuasaan Moammar Khadafi di Libya
Authors: M Jenni Irene Corry , Septiani Karina , Diki Maulana
Published: July 2020

In the concept of the internal conflict, Michael Brown explained there are political factors, economic, social, cultural and structural contribute to conflict within a country. The fourth order assist researchers in analyzing the causes of the coup against Moammar Gaddafi in Libya. During the 42-year reign of Moammar Gaddaf, the Libyan people have political issues such as curbs on political activity, political institutional discrimination, exclusive state ideology, significant internal political groups and the role of the political elite that interfere with the freedom of the people. Then economic issues such as economic discrimination, unemployment, and corruption in the Gaddafiâ€™s family that give rise to high social inequalities. Coupled with the structural and socio-cultural factors such as discrimination against minorities, gender, and state institutions are not effective as inhibitors of the country's development. Gaddafi uses his own thoughts in undergoing government, by creating the Green Book rules as guidelines for political, economic, and social. Began when the Arab Spring swept Tunisian and Egyptian people who successfully staged a coup against their leader, there arises a sense of longing for the same freedom. Then triggered by the arrest of human rights campaigner who conducted the country's security forces in February 2011 and the blocking of internet sites in the emergence of large demonstrations - demanding the release of their scale and the overthrow of Moammar Gaddafi in the Libyan leadership.Â
Implementasi Kebijakan Pengelolaan dan Pengusahaan Sarang Burung Walet di Kota Pekanbaru
Authors: Wendra Rinaldy May , Afrizal Teuku , Supriyono Eko , Setiono Siauw Tiffani , Fatimah Annisa Nurfitriani
Published: July 2020

The policy on management and management of swallow nests aims to regulate the management and management of swallow nests in order to contribute to the community and local government. This policy was outlined in Pekanbaru City Regulation Number 3 of 2007 concerning Business Permit for the Management and Management of Swallow's Nest. Several problems arise, among others, the number of business licenses that are still very minimal which has an impact on the contribution of regional income, noise pollution, air pollution, environmental impacts and health problems. This study aims to analyze the implementation of management policies and management of swallow's nests in Pekanbaru City. This research uses a qualitative descriptive approach through literature study. Analysis of policy implementation is seen through the Edward III model, which pays attention to the effectiveness of implementation in terms of communication, resources, disposition and bureaucratic structure. The results of the study concluded that the implementation of the management and management policy for swallow nests has not run effectively. In controlling the swallow breeding business permit, there are many obstacles, among others, coordination between related agencies that has not been running well, supervision by related agencies which is still very low, low levels of employer compliance due to sanctions that have never been applied, so there needs to be an evaluation of policies when this is by paying more attention to environmental impacts and firmer sanctions.
Pengelolaan Kawasan Wisata Suku Anak Dalam Berbasis Kearifan Lokal
Authors: Wazan Syafik , Astuti Retno Sunu , Kismartini Kismartini , Afrizal Teuku
Published: July 2020

The purpose of this study is to analyze the Management of the Children in the Tourism Area of the Children in the Tribe and to find out the obstacles in the management of the Children in the Tourism Area in the Bukit Duabelas National Park, the Sorolangun Regency, the Jambi Regency. The theory uses the opinion of Cox (1985) in Pitana (2009) on tourism management must pay attention to principles such as Development, Preservation, Development, Service and Regulation / legal certainty. The research method uses a descriptive qualitative approach. This research was carried out in the settlement of the Children of the Tribe in the Sorolangun Regency, Jambi Province. Data collection uses observation, interviews (FGD), and Documentation / Similar Research. The results of research on the management of the Suku Anak Dalam tourism area (SAD) have provided comfort to visitors without disturbing or disturbing the ecosystem or the authenticity of the tourist attractions. With the existence of this educational tourism management will increase the original income of the region in the field of tourism. This must be maintained so that later other tourism objects will emerge. It's just that there is a need for a regional regulation for the development of special tourism areas for children in the tribe so that treatment can be felt directly to the community.
RANDOM STRATEGY VERSUS TECHNICAL ANALYSIS STRATEGY: THE CASE OF EUR/USD INTRADAY TRADING
Authors: Svoboda Miroslav , Sponerová Martina
Published: July 2020

This paper provides a comparison between the strategy based on technical analysis
and the strategy based on random trading on a highly liquid EUR/USD foreign exchange market. The authors analyze three years of data, and in every intraday trading session. Technical analysis strategy uses essential indicators such as moving averages (MA). Every trading position will have the risk-reward ratio (RRR) 3 to 1. In addition, another trading positions on the EUR/USD currency pair will be opened at the same time each day, without technical analysis. The time of entry into position will be indicated by past high liquidity on a given currency pair at a given time with a similar risk-reward ratio (RRR) 3 to 1. This paper aims to compare the strategy of technical analysis and the random strategy in intraday trading concerning the profitability of these trades.
EFFECTS OF ACHIEVING SUPPLY CHAIN FLEXIBILITY
Authors: Veselovská Lenka
Published: July 2020

This research study focuses on the current topic of supply chain management which
serves as a tool for manufacturing enterprises to cope with pressure put on them by continuously changing market conditions and the global economy itself. Paper presents the results of research conducted on the sample file of Slovak production enterprises. The main aim of this research study is to explore the extent of achieving agility, adaptability and alignment as secondary effects of supply chain flexibility in Slovak manufacturing enterprises. Representativeness of the sample file was confirmed by the application of Pearson´s chi-squared test (χ2 - test) due to the criterion of an enterprise’s size. The results of this research provide a clear image of business reality in terms of supply chain organization and therefore have implications for business practice which may serve managers in their decision-making process in supply chain management.
REAL OPTION ANALYSIS OF VENTURE CAPITAL INVESTMENTS
Authors: Posza Alexandra
Published: July 2020

Venture capital investments play an important role in the development and growth of start-up companies that are characterized by a high degree of uncertainty and growth potential, and venture capital is also one of the major sources of financing for entrepreneurial businesses. In the case of venture capital investment, staging has a huge potential, so the venture capitalists keep the right to participate in further financing rounds. The real option approach as an evaluation method provides an opportunity to evaluate this kind of investment with the help of flexibility in the case of a high degree of uncertainty. The paper puts the emphasis on the evaluation and the effectiveness of venture capital investments primarily from the aspect of real option theory tested on Hungarian venture capital cases. The paper concludes that the option-based valuation methods are more suitable for evaluating venture capital investments than others, especially the discounted cash flow method.
Orígenes y desarrollo de la teoría de la agenda setting en Comunicación. Tendencias en España (2014-2019)
Authors: Ardévol-Abreu Alberto , Gil de Zúñiga Homero , McCombs Maxwell E.
Published: July 2020

The core hypothesis of the theory of agenda setting is that there is a process of transfer of salience from the media agenda to the public agenda. Since its original conception in the early 1970s, the explanatory model of ‘issue-agenda setting’ (first level) has been extended to help explain the transfer of the media’s ‘attribute agenda’ (second level) and ‘network agenda’ (third level) to the public agenda. This article provides a review of the agenda-setting model and its theoretical and empirical development, ending with a section that summarizes and discusses research studies published in this area in the last five years in Spain. Despite the broad influence of the agenda-setting theory in communication research in this country, Despite the broad influence of the agenda-setting theory in communication research in this country, many of the studies use the theory as a general framework for conducting a content analysis, withouh empirically testing any process of salience transfer.

Resumen
La teoría de la agenda setting establece como hipótesis central que existe un fenómeno de transferencia de relevancia desde la agenda de los medios de comunicación hasta la agenda del público. Desde su formulación en los años 70 del siglo XX, el modelo explicativo de la agenda setting de asuntos (primer nivel) se ha ido ramificando para poder explicar la transmisión de la agenda de los atributos (segundo nivel) y la agenda de redes –o relaciones– (tercer nivel). El presente artículo lleva a cabo una revisión del modelo y su evolución teórica y empírica, para acabar acercándose a su utilización en la investigación publicada en España en el último quinquenio. A pesar de la amplia repercusión de la agenda setting en la investigación publicada en este país, muchos de los trabajos utilizan la teoría como marco general para llevar a cabo análisis de contenido sin llegar a plantear (empíricamente) ningún fenómeno de transferencia de relevancia.
New species of bombardier beetles of the genera Brachinus and Pheropsophus (Coleoptera: Carabidae: Brachininae) from Vietnam
Authors: Fedorenko D.N.
Published: July 2020

Eight new species of bombardier beetles are described from Vietnam: Brachinus dalatensis sp. nov., B. ovalipennis sp. nov., B. belyaevae sp. nov. (all in the melancholicus species-group), Pheropsophus (Stenaptinus) bidoupensis sp. nov., Ph. (S.) ngoclinhensis sp. nov., Ph. (S.) kalyakini sp. nov., Ph. (S.) similis sp. nov. and Ph. (S.) obliteratus sp. nov. (all in the aptinoides species-group). A key to species of the Pheropsophus aptinoides group of the Vietnamese fauna is provided.
The Happy Place That Exists Nowhere
Authors: Storey John
Published: July 2020

Contrary to dominant debates about Utopia, I do not think it matters whether Thomas More actually believed that ‘communism’ was the solution to social inequality and injustice; what I think is important is that the book raises the question of a different type of society. As I argue in the second part of my article, the power of Utopia, like all radical utopianism, derives not from the production of blueprints; rather, it comes from the stimulation of desire for a ‘happy place’, which can reflect negatively on, and produce discontent within, the here and now. Understood in this way, radical utopianism offers a form of resistance to dominant constructions of reality and our complicity, conscious and unconscious, with them.
Absent Felicity
Authors: Sanders Andrew
Published: July 2020

‘Happiness’, as we now commonly understand the term, is not something we should expect to meet in Shakespeare’s work. When he employs alternative words – such as ‘felicity, ‘merry’ or ‘blessed’ – he rarely seeks to convey what latter-day readers might assume to be the concept of ‘happiness’ that we accept as an agreeable state of mind. Shakespeare’s ‘happy’ seems to apply to circumstances rather than to a state of mind. His characters often appear to be luckier in their happiness rather than actual achievers of happiness. The idea that the ‘pursuit of happiness’ is an essential part of the definition of the human condition (as in the founding documents of the American Revolution) may well owe far more to John Milton’s use of the words ‘happy’ and ‘happiness’ and the common acceptance of ‘happiness’ as a socially and politically desirable condition.
OPPORTUNITIES OF ADJUVANT THERAPY WITH PIOGLITAZONE OF NON-ALCOHOLIC FATТУ LIVER DISEASE СO-OCURRING WITH OBESITY
Authors: Shypulin V.P. , Melnyk N.G.
Published: July 2020

Relevance. The «Global Action Plan for the Prevention and Control of Noncommunicable Diseases 2013-2020» approved by the WHO is dedicated to noncommunicable diseases. Among them - diabetes mellitus, which is a consequence of overweight \ obesity and lack of exercise. Pioglitazone is the only drug on the pharmacological market for the treatment of non-alcoholic steatohepatitis (NASH), regardless of diabetic mellitus status. Currently, the treatment of early NASH in the prevention of both type 2 diabetes and CVD, and amelioration of NASH progression is a priority task.
Objective – to study the effectiveness of treatment with pioglitazone in patients with obesity and non-alcoholic fatty liver disease (NAFLD).
Materials that methods. 123 patients with obesity 1, 2, 3 classes in combination with NAFLD were included in our research during 3 months. The randomization method of patients was divided into two groups, comparable in age, sex, and body mass index. All patients were offered drug-free treatment that included lifestyle modification: a reduction in diet of 500 kcal from the physiological daily energy expenditure and its physical activity for 150-200 min per week, the problems of adherence to recommendations were additionally discussed during the visits. The patients of the case group adhered to the basic recommendations and received pioglitazone 15 mg / day additionally as a drug treatment. Patients in the control group adhered only to principles of drug-free treatment. Overall, the program consisted of 5 visits over 3 months period. All patients underwent anthropometric measurements, laboratory and instrumental examinations (Ultrasound steatometry) before and after 12 weeks of treatment. Also studied adherence to treatment in two groups of patients using self-report questionnaire.
Results. A comparative analysis of the data obtained in patients with obesity and NAFLD from the group of pioglitazone (daily dose of 15 mg) revealed the best major metabolic markers, such as significantly decreased values in waist circumference (p<0,0001), uric acid (p=0,001), thriglycerides (p=0,02) and very low density lipoproteins cholesterol(p=0,003), atherogenic coefficient (p=0,002), fasting insulin (p=0,004) and C-peptide, HOMA-IR index (p=0,01) and increased level of high density lipoproteins cholesterol (p=0,009), respectively. A significant association was found between the target reduction of controlled attenuation parameter and treatment with pioglitazone 15 mg (OR 0,27, 95% CI 0,13–0,56, p=0,001). The dynamics of steatosis had a medium correlation with the final adherence level (r=0,52), regardless of the method of treatment.
Conclusions. It was found that in Ukrainians with obesity and NAFLD, moderate steatosis occurs in 73% of cases. Pioglitazone is a significantly highly effective drug for the adjuvant therapy of NAFLD.
AUTOLOGOUS BLOOD COMPONENTS AND THEIR PERFORMANCE IN SCAFFOLDES MADE BY ORIGINAL TECHNOLOGY
Authors: Chumachenko O.V. , Topchiі D.V. , Gromovy Y.S. , Plyatsko S.V.
Published: July 2020

Relevance. It is believed that when scaffolds fill in bone defects after removal of jaw cysts or revision of inflammatory foci, a new bone grows from the periphery to the center, replacing the graft and at the same time changing its properties. Delivery of all materials necessary to start the reparative process begins with the contact area of ​​the bone bed and scaffold. The properties of the material for making the scaffold and its hydrophilicity determine its ability to incorporate chemical and cellular material from surrounding tissues.

Scaffold properties can be programmed. The properties of the fluid conductor from the wall of the bone defect to the implanted material are also important. The use of autologous blood components for this role becomes attractive.

Objective: to study the composition of autologous blood components prepared using simplified technology, and their interaction with scaffolds of the original design in the treatment of patients with destructive periodontitis and jaw cysts.

Materials and methods. Microscopic examination of the components of autologous blood and their ability to penetrate into the scaffold during surgical preparation.

Results. Microscopic examination of autologous blood after centrifugation showed a platelet count in plasma similar to the norm, increased in the liquid from the gel, as well as their presence in the gel itself and in the gel membrane. A small increase in the number of leukocytes compared to the norm is determined in the liquid obtained from the gel. In the remaining blood components, the number of leukocytes in our micropreparations is not determined. The proposed original scaffold with initial cell sizes of 10 μm during immersion in the liquid components of autologous blood showed great absorption potential against the background of the possibility of increasing its porosity.

Conclusions. The proposed simple technique for obtaining the components of autologous blood allows you to create such an environment on the border of the "bone bed-scaffold", where platelets, white blood cells and biochemical blood components are concentrated in the required quantity. On the other hand, the proposed original design of the scaffold allows, in the process of filling it with a mixture of the liquid components of autologous blood, an increase in cell sizes, which leads to an increase in the absorption volume and contact area. Both of these circumstances make it possible to achieve the necessary incorporation of biological material already before scaffold is introduced into bone defects.
PERIODONT TISSUES STATUS AND FEATURES OF CLINICAL COURSE OF APICAL PERIODONTITIS OF PERMANENT TEETH WITH DISORDERS OF ROOT FORMATION AS A RESULT OF INJURY
Authors: Plyska O. , Chehertma E. , Lehenchuk O.
Published: July 2020

Relevance. In childhood, traumatic tooth injuries are often found. Pulp necrosis occurs in 34,2 % of injured teeth, this causes damage to the periapical tissues. The post-traumatic complications (odontogenic cysts, periodontitis) in teeth with incomplete root formation often lead to a halt in root development. Chronic nidus of infection can be the cause of the somatic pathology development. This makes the early clinical and radiological diagnosis of post-traumatic complications important.

Objective of the work is to study the clinical features of the post-traumatic periodontitis of permanent teeth with incomplete root formation of the tooth and to assess the condition of periodontal tissues in permanent teeth with impaired root formation as a result of trauma based on data from clinical and radiological studies.

Materials and methods. On follow-up there were 17 children 9-15 years old with post-traumatic periodontitis of permanent teeth with incomplete formation of the root of the tooth. When making the diagnosis, we  relied on data from clinical and radiological studies.

Results. Most children complained of an aesthetic defect. 9 children (52,9 %) after an acute tooth injury did not seek the help of a dentist, аfter treatment of 8 children, dynamic observation was not conducted. In 76 % (13 teeth) periodontitis is diagnosed in teeth with a crown fracture within the enamel, enamel and dentin.

It has been established that chronic granulating periodontitis is the most common form among destructive forms of periodontitis (12 teeth – 70,6%). Exacerbation of chronic granulating periodontitis diagnosed in 5 teeth. We did not ascertain chronic granulomatous periodontitis in teeth with incomplete root formation. The prevalence of the granulating form of chronic periodontitis in children is due to the histomorphological features of periodontal disease in childhood.

 8 children, among the examined had a bite pathology – protrusion of the teeth of the front of the jaw (5 children) and a distal deep bite (3 children). In 71% of lesions, destructive forms of periodontitis were most often diagnosed in the maxillary incisors.

Conclusion. Untimely seeking help and the lack of dynamic monitoring of injured teeth are the main reasons for the development of post-traumatic periodontitis. The clinical course of periodontitis is peculiar – chronic granulating periodontitis predominates, the inflammatory process in periodontal tissues in childhood is characterized by rapidly progressive destruction of bone tissue. Malocclusion can be a risk factor for tooth injuries.
TREATMENT RESPONSE PREDICTION IN PATIENTS WITH RHEUMATOID ARTHRITIS. Review
Authors: Fedkov D.L. , Komkina M.O.
Published: July 2020

Relevance. A variety of targeted therapies for rheumatoid arthritis (RA) treatment exist. Therefore, reliable predictors are needed that could be used to accurately predict the efficacy or inefficacy of these therapies in individual patients. This could allow clinicians to improve diagnosis and prognosis, to make the treatment personalized and to reduce healthcare expenses.

Objectives: to analyze and systemize the predictors of response to treatment in patients with RA.

Materials and Methods. We analyzed the recently discovered predictors of treatment response in RA patients using papers cited on PubMed, Lilacs, and EMBASE databases from Jan 2005 until Jan 2020.  Predictive factors were grouped into four categories: methotrexate (MTX)-treated RA, tumor necrosis factor (TNF)-α inhibitors-treated RA, interleukin (IL)-6 inhibitors-treated RA, and rituximab (RTX)-treated RA.

Results. Based on the results of several studies, predictors of response to methotrexate were high Disease Activity Score (DAS), concentration of myeloid-related proteins 8/14, high P-glycoprotein levels, low serum calprotectin and leptin levels, baseline serum concentration of tumor necrosis factor (TNF)-α, TNF receptor I, interleukin (IL)-1β, soluble CD163, numbers of CD14+highCD16, vascular cell adhesion molecule, lower expression of hsa-miR-132-3p, hsa-miR-146a-5p, and hsa-miR-155-5p. A positive response to biological therapy was determined by male gender, younger age, lower health assessment questionnaire, erythrocyte sedimentation rate or C-reactive protein, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, tender joint count (or swollen joint count) scores, absence of comorbidities, baseline albumin, IL-34, IL-1β, D-dimer, fibrinogen, matrix metalloproteinase 3, DAS 28 and Simplified Disease Activity Index (SDAI). The plasma interferon (IFN) activity and the IFN beta/alpha ratio, IL-1Ra level were predictive in TNF antagonist-treated patients. Predictors of response to IL-6 inhibitors were anti–citrullinated protein antibody (ACPA)+, baseline Sharp/van der Heijde score, myeloid soluble intercellular adhesion molecule 1, serum levels of sIL-6R, IL-8, calprotectin, and lymphoid activation and bone remodeling markers. The prediction of the best response for rituximab was determined to be a combination of IL-33, rheumatoid factor or ACPA, IgG, and also lower number of previous biological therapies. Genetic factors, such as single-nucleotide polymorphisms at gene locus rs10919563, rs11541076, rs12083537, rs11265618, and rs1801274, and rs396991 can also be used to predict a response to treatment.

Conclusions. One of the leading problems in the development of predictors remains the collection of high-quality and complete information from a large number of patients. For this, it is necessary to develop an digital program for collecting specific data (depending on the specific disease) and developing new algorithms for predicting the response to treatment.
La interdependencia entre economía y política en la democracia
Authors: Recio Figueiras Eugenio
Published: July 2020

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Los fraudes comerciales
Authors: Acebrdo Francisco
Published: July 2020

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La industria farmacéutica en España
Authors: Donoso Vicente
Published: July 2020

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Desigualdades e injusticias en los países industriales
Authors: Redacción Consejo de
Published: July 2020

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La desigualdad social y la dinámica de las relaciones de fuerza
Authors: Bundervoet Jan
Published: July 2020

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Las fuerzas sociales frente a la desigualdad
Authors: Hoefnagels Harry
Published: July 2020

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Papel del municipio y la provincia en el proceso hacia la autonomía de las nacionalidades y regiones
Authors: García Matías
Published: July 2020

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La crisis de la democracia en la perspectiva trilateral (Europa, Estados Unidos, Japón)
Authors: Sánchez Aizcorbe César
Published: July 2020

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Value Priorities of Modern Youth in Social Adaptation
Authors: Shipunova O. D. , Berezovskaya I. P.
Published: July 2020

Introduction. The paper is devoted to the values that highlight terminal value orientations that determine the criteria for a young person's attitude to social life. Basic axiological settings play a key role in the processes of situation assessment, individual self-regulation while choosing and implementing a proper form of behavior. The aim of our research is analyzing the structure of the value system of young people by age and gender. The research objectives include identifying the value priorities of youth at the age of 15 to 17, which form the basis for constructing life strategies in social adaptation. The scientific novelty of the research lies in the specifics of researching the axiology of social adaptation, due to the measured parameters of the motivational structure of the personality and interdisciplinary research.

Methodology and sources. The research is conducted on the theoretical basis of social philosophy and psychology within the framework of the activity concept of the personality, using comparative analysis, psychological testing methods and standardized self-reports according to the questionnaire “Terminal Values” by I. G. Senin. The research was conducted in St. Petersburg in May 2019, 64 respondents aged 15-17 years took participation in the empirical research, of which 38 were boys and 26 were girls.

Results and discussion. Young people in the reference group present empirical findings in the structural diagram that demonstrates the average level of the basic values expression. This corresponds to the person's inherent style of adaptive behavior in social sphere of his or her life world. It is found that in the system of terminal values for both boys and girls, common priority is given to spiritual gratification in the implementation of life plans (33 %). 27 % of young men surveyed in social adaptation are value-oriented to preserve their own individuality. A comparative analysis of the value priorities for boys and girls shows the difference in life strategy motivation. Among the young people in the reference group, target orientations on their own prestige, active social communication and spiritual gratification are of higher significance in the processes of social adaptation.

Conclusion. In conclusion, we can note a clearly expressed axiological orientation of youth on the value of family relations, with which both boys and girls associate the formation of their intellectual and communicative potential of life strategies in social adaptation. The results of this research are important for the research of basic axiological attitudes, and the distinguished types of value orientations allow us to outline programs for the formation of social adaptation, as well as reflection on the meaning of the realization of goals.
ЗОВНІШНЬОЕКОНОМІЧНА ДІЯЛЬНІСТЬ ЯК ФАКТОР АКТИВІЗАЦІЇ ІНВЕСТИЦІЙ В БРЕСТСЬКА ОБЛАСТЬ БІЛОРУСІЇ
Authors: Пригодич И. А. , Конончук И. А. , Киевич А. В.
Published: July 2020

Investment in the country is the most effective and efficient driver of the economy. Their availability will inevitably lead to effective employment through the creation of new jobs, and deep modernization. Increasing the competitiveness of goods will contribute to the growth of sales, exports and foreign exchange earnings in the country. The purpose of the article is to characterize foreign economic activity as a factor in intensifying investments in the Brest region of Belarus. Methods used in the study. The use of the induction method allowed us to identify areas for improving the procedures for determining the effectiveness of the application of tax benefits. Research hypothesis. In the Republic of Belarus, this is favored by a well-developed transport infrastructure, an extensive network of Railways and highways, modern logistics centers, and a highly qualified workforce. The key factor in the growth of the country's economy is the investment of funds in the regions. Statement of the main material. The modern Brest district is a region where light industry, agriculture, food industry, construction industry, forestry, and woodworking are actively developing. The geographical position of the region on the border with the European Union creates favorable conditions for trade and investment cooperation with European countries. The products of JSC ”Savushkin product“, the Belarusian-German joint venture ”Santa Bremor“ and the Belarusian-Russian joint venture ”Brestgazoapparat“, and the holding company ”Pinskdrev“ are widely known on the world markets. The national center for marketing and pricing study of the Ministry of foreign affairs will continue to promote economic cooperation between enterprises of the Brest region and foreign partners. Originality and practical value. The free economic zone ”Brest“ has been created and is successfully operating in the region, the advantages of which are well known to investors far beyond the country's borders. The residents of this economic zone have successfully used tax and customs benefits, guarantees in respect of the ownership and disposition of profit. In addition to the benefits provided in the free economic zone, preferences also apply when investing in objects located in small towns and rural areas. Conclusions. The Brest region can offer foreign investors comfortable working conditions and profitable projects. In total, the region's investment portfolio includes more than 20 offers totaling more than 100 million dollars.In the article, analyzes the effectiveness of foreign economic activity of the Brest region of the Republic of Belarus and appreciates its investment potential. The assessment of the economic activity of the region allows us to draw conclusions not only about the weaknesses and strengths of key economic entities, but also to identify the prospects for the development of the Brest region by increasing the use of existing benefits and preferences.