bluuebunny/crossref_metadata_2025 huggingface dataset:
Biphenotypic Sinonasal Sarcoma: A Genetically Confirmed Case Showing Bone Invasion Accompanying a Non-neoplastic Respiratory Epithelium
Authors: Muraoka Erika , Kato Ikuma , Matsumura Mai , Arai Yasuhiro , Suenaga Jun , Yamanaka Shoji , Fujii Satoshi
Published: February 2023

Biphenotypic sinonasal sarcoma is a newly established tumor entity that is associated with distinct clinicopathological findings. Biphenotypic sinonasal sarcoma is a rare, low-grade spindle cell sarcoma that arises in middle-aged females, exclusively in the sinonasal tract. A fusion gene involving PAX3 is detected in most biphenotypic sinonasal sarcomas, which aids in its diagnosis. Here, we report a case of biphenotypic sinonasal sarcoma with its cytological findings. The patient was a 73-year-old woman who presented with purulent nasal discharge and dull pain in the left cheek area. Computed tomography showed a mass extending from the left nasal cavity to the left ethmoid sinus, the left frontal sinus, and the frontal skull base. She underwent a combined transcranial and endoscopic approach for en bloc resection with a safety margin. Histologically, spindle-shaped tumor cells have been thought to proliferate mainly in the subepithelial stroma. Here, nasal mucosal epithelial hyperplasia was noted, and the tumor had invaded the bone tissue accompanying the epithelial cells. Fluorescence in situ hybridization (FISH) analysis showed a PAX3 rearrangement, and next-generation sequencing identified a PAX3::MAML3 fusion. Based on FISH, split signals were observed not in respiratory cells but in stromal cells. This indicated that respiratory cells were non-neoplastic. In the diagnosis of biphenotypic sinonasal sarcoma, the inverted growth of the respiratory epithelium can be a diagnostic pitfall. FISH analysis using a PAX3 break-apart probe is helpful not only for an accurate diagnosis but also for detecting the true neoplastic cells.
Gut-associated Lymphoid Tissue/Dome-Type Carcinoma of the Colon: A Rare Case Report With Review of the Literature
Authors: Tang Hao , He Yutao , He Xin , Xu Juan , Wang Zhengyong , Guo Deyu
Published: February 2023

Gut-associated lymphoid tissue (GALT) carcinoma, also termed dome-type carcinoma, is an infrequent distinctive subtype of colorectal adenocarcinoma and only 18 cases have been reported in the English medical literature. These tumors have unique clinicopathological features and are considered to have a low malignant potential with favorable prognosis. Herein, we described a case of a 49-year-old male with intermittent hematochezia for 2 years. Colonoscopy revealed a sessile broad-based polyp of approximately 20 mm × 17 mm in the sigmoid colon 260 mm away from the anus, with a slightly hyperemic surface. Histologically, this lesion showed typical GALT carcinoma. The patient was followed up for one and a half year and he did not experience any discomfort, such as abdominal pain or hematochezia, and no tumor recurrence occurred. Moreover, we reviewed the literature, summarized the clinicopathological features of GALT carcinoma, and highlighted its pathological differential diagnosis to further explore this infrequent type of colorectal adenocarcinoma.
Increased In Vivo Thrombin Generation in Patients with Localized Non-Small Cell Lung Cancer Unfit for Surgery
Authors: Hojbjerg Johanne Andersen , Bentsen Kristian Kirkelund , Vinholt Pernille Just , Hansen Olfred , Jeppesen Stefan Starup , Hvas Anne-Mette
Published: February 2023

Patients with lung cancer face a substantially increased risk of thromboembolic disease. Patients with localized non-small cell lung cancer (NSCLC) who are unfit for surgery due to age or comorbidity have additional thrombotic risk factors. Thus, we aimed to investigate markers of primary and secondary hemostasis, since this could assist in treatment decisions. We included 105 patients with localized NSCLC. Ex vivo thrombin generation was determined by calibrated automated thrombogram and in vivo thrombin generation was determined by measurement of thrombin–antithrombin complex (TAT) levels and prothrombin fragment F1 + 2 concentrations (F1 + 2). Platelet aggregation was investigated by impedance aggregometry. Healthy controls were used for comparison. TAT and F1 + 2 concentrations were significantly higher in NSCLC patients than in healthy controls ( P < .001). The levels of ex vivo thrombin generation and platelet aggregation were not increased in the NSCLC patients. Patients with localized NSCLC considered unfit for surgery had significantly increased in vivo thrombin generation. This finding should be further investigated as it could be relevant for the choice of thromboprophylaxis in these patients.
Effect of Anticoagulant Versus Non-Anticoagulant Therapy on Mortality of Sepsis-Induced Disseminated Intravascular Coagulation: A Systematic Review and Meta-Analysis
Authors: Qi Wenqian , Liu Jingyuan , Li Ang
Published: February 2023

Background

Sepsis is a syndrome of severe systemic inflammatory response. When combined with disseminated intravascular coagulation, mortality is increased. The need for anticoagulant therapy is still the focus of debate.

Methods

PubMed, Embase, Cochrane Library, and Web of Science were searched. Adult patients with sepsis-induced disseminated intravascular coagulation were included in this study. All-cause mortality as efficacy and serious bleeding complications as adverse effect were measured as primary outcomes. Methodological quality of included studies were assessed using the Methodological Index for Non-randomized Studies (MINORS). Meta-analysis was performed using R software (version 3.5.1) and Review Manager (version 5.3.5).

Results

There were nine eligible studies with 17,968 patients included. There were no significant reductions in mortality between the anticoagulant group and the non-anticoagulant group (RR, 0.89; 95% CI, 0.72–1.10; P = 0.27). The DIC resolution rate in the anticoagulation group has a statistically significant increase compared with the control group [OR: 2.62, 95% CI (1.54–4.45), P < 0.05]. And there was no significant difference in bleeding complications between the two groups (RR, 1.27; 95% CI, 0.77–2.09; P = 0.69). SOFA score reduction did not change significantly between the two groups ( P = 0.13).

Conclusions

Our study observed no significant benefit of anticoagulant therapy on mortality of sepsis-induced DIC. Anticoagulation therapy can promote DIC resolution in sepsis-induced DIC. In addition, anticoagulant therapy does not increase the risk of bleeding in these patients.
Neuropsychological and Symptom Predictors of Diagnostic Persistence in ADHD: A 25-Year Follow-up Study
Authors: Øie Merete Glenne , Storaas Tor Amund Voll , Egeland Jens
Published: February 2023

Background:

This study extends long-term predictive research on ADHD by including both neuropsychological and symptom measures at baseline in adolescence as predictors of diagnostic persistence 25 years later.

Methods:

Nineteen males with ADHD and 26 healthy controls (HC; M/F = 13/13), were assessed in adolescence and 25 years later. Measurements at baseline included a comprehensive test battery measuring eight neuropsychological domains, an IQ estimate, the Child Behavior Checklist (CBCL), and the Global Assessment Scale of Symptoms. Differences between ADHD Retainers, Remitters, and HC were calculated with ANOVAs, and potential predictions of differences in the ADHD group by linear regression analyses.

Results:

Eleven (58%) participants retained their ADHD diagnoses at follow-up. Motor Coordination and Visual perception at baseline predicted diagnosis at follow-up. CBCL Attention problems at baseline in the ADHD group predicted variance in diagnostic status.

Conclusion:

Lower-order neuropsychological functions related to motor function and perception are important long-time predictors of persistence of ADHD.
Refractory Hypotension During Implantation of a 70 mL Total Artificial Heart in a Patient With Pectus Excavatum: A Case Report
Authors: Hart Brendon , Mokadam Nahush A. , Anam Karina , Saklayen Samiya , Dimitrova Galina , Zuleta-Alarcon Alix , Holloway Jordan , Awad Hamdy , Convissar David , Essandoh Michael
Published: February 2023

The Syncardia total artificial heart system is the only commercially approved durable device for treating biventricular heart failure patients awaiting heart transplantation. Conventionally, the Syncardia total artificial heart system is implanted based on the distance from the anterior aspect of the 10th thoracic vertebra to the sternum and the patient's body surface area. However, this criterion does not account for chest wall musculoskeletal deformities. This case report describes a patient with a pectus excavatum who developed compression of the inferior vena cava after Syncardia total artificial heart implantation and how transesophageal echocardiography guided chest wall surgery to accommodate the total artificial heart system.
Partial retention of the acetabular cement mantle in aseptic revision hip arthroplasty: is it a viable option?
Authors: Swanton Eric , Whitehouse Sarah L , Hubble Matthew JW
Published: February 2023

Introduction:

Choosing the most appropriate reconstruction method when addressing a cemented cup at hip revision surgery can be a difficult decision. The aim of this study is to look into the practice and results of retaining a well-fixed medial acetabular cement mantle while removing loose superolateral cement. This practice goes against a preconceived principle that if some of the cement is loose it must all be removed. So far, no significant series looking at this is available in the literature.

Methods:

We assessed a cohort of 27 patients in our institution where this practice was carried out and assessed their outcomes clinically and radiographically.

Results:

Of the 27 patients, 24 had follow-up ⩾2 years (2.9–17.8, mean 9.3 years). There was 1 subsequent revision for aseptic loosening at 11.9 years, 1 first-stage revision of both stem and cup for infection at 1 month, and 2 patients died without a 2-year review. 2 patients did not have radiographs available for review. 2 of the 22 patients with radiographs available had changes in lucent lines, which were not clinically significant.

Conclusion:

Based on these results we conclude that retaining well-fixed medial cement during socket revision is a viable reconstruction option in carefully selected cases.
Pharmacological Interventions for Primary Psychodermatologic Disorders: An Evidence Mapping and Appraisal of Randomized Controlled Trials
Authors: Turk Tarek , Liu Chaocheng , Fujiwara Esther , Straube Sebastian , Hagtvedt Reidar , Dennett Liz , Abba-Aji Adam , Dytoc Marlene
Published: February 2023

Background

The lack of clinical guidelines for the treatment of primary psychodermatologic disorders (PPDs) hinders the delivery of optimal care to patients. The review aimed to identify, appraise, and summarize the currently available evidence about the safety and effectiveness of pharmacological management of PPDs through randomized controlled trials (RCTs).

Methods

The Preferred Reporting Items for Systematic Review and Meta-Analyses (PRIMSA) statement and the Global Evidence Mapping Initiative guidance were followed. Medline, Embase, PsycInfo, Cochrane and Scopus were searched, and two reviewers independently completed article review, data extraction, and quality assessment.

Results

Among 2618 unique studies, full texts of 83 were reviewed and 21 RCTs were included. Five PDDs were identified: trichotillomania ( n = 12), pathologic skin picking ( n = 5), nail biting ( n = 2), delusional parasitosis ( n = 1), and dermatitis from compulsive hand washing ( n = 1). Seven different classes of medications were investigated: SSRIs (i.e., fluoxetine, sertraline, and citalopram), tricyclic antidepressants (i.e., clomipramine and desipramine), antipsychotics (i.e., olanzapine and pimozide), anticonvulsant (i.e., lamotrigine), N-acetylcysteine, inositol, and milk thistle. RCT-derived evidence supports the use of antidepressants in trichotillomania (sertraline and clomipramine), pathologic skin picking (fluoxetine), pathologic nail biting and dermatitis from compulsive hand washing (clomipramine or desipramine); antipsychotics in trichotillomania (olanzapine) and delusional parasitosis (pimozide); N-acetyl cysteine in trichotillomania and skin picking.

Conclusion

Few pharmacotherapies for primary psychodermatologic disorders are assessed through controlled trials in the literature. This review serves as a roadmap for researchers and clinicians to reach informed decisions with current evidence, and to build on it to establish guidelines in the future.
Genetic regulation of IL-8 influences disease presentation of multiple sclerosis
Authors: Dolcetti Ettore , Bruno Antonio , Azzolini Federica , Gilio Luana , Pavone Luigi , Iezzi Ennio , Galifi Giovanni , Gambardella Stefano , Ferese Rosangela , Buttari Fabio , De Vito Francesca , Colantuono Paola , Furlan Roberto , Finardi Annamaria , Musella Alessandra , Mandolesi Georgia , Centonze Diego , Stampanoni Bassi Mario
Published: February 2023

Background:

Individual genetic variability may influence the course of multiple sclerosis (MS). The interleukin (IL)-8C>T rs2227306 single nucleotide polymorphism (SNP) regulates IL-8 activity in other clinical conditions; however, its role in MS has never been investigated.

Objectives:

To explore the association between IL-8 SNP rs2227306, cerebrospinal fluid (CSF) IL-8 concentrations, clinical, and radiological characteristics in a group of newly diagnosed MS patients.

Methods:

In 141 relapsing-remitting (RR)-MS patients, rs2227306 polymorphism, CSF levels of IL-8, clinical, and demographical characteristics were determined. In 50 patients, structural magnetic resonance imaging (MRI) measures were also assessed.

Results:

An association between CSF IL-8 and Expanded Disability Status Scale (EDSS) at diagnosis was found in our set of patients ( r = 0.207, p = 0.014). CSF IL-8 concentrations were significantly higher in patients carrying the T variant of rs2227306 ( p = 0.004). In the same group, a positive correlation emerged between IL-8 and EDSS ( r = 0.273, p = 0.019). Finally, a negative correlation between CSF levels of IL-8 and cortical thickness emerged in rs2227306T carriers ( r = −0.498, p = 0.005).

Conclusion:

We describe for the first time a role of SNP rs2227306 of IL-8 gene in regulating the expression and the activity of this inflammatory cytokine in MS.
Metaverse research propositions: Online intermediaries
Authors: Ampountolas Apostolos , Menconi Giuseppina , Shaw Gareth
Published: February 2023

One of the sectors with the fastest growth rates worldwide is the hospitality and tourism industry, although the pandemic caused losses and setbacks for the industry. The potential of the metaverse and virtual travel could lead to the emergence of a brand-new sector. Thus, traditional online travel agencies may need to change their utility model in the future to accommodate the new technology. This virtual transformation in the metaverse entails more flexible travel options, customized consumer services, and improved entertainment. The employment of augmented and virtual reality technology in the metaverse may enable seamless interaction between users in real and simulated surroundings. As such future developments in metaverse technology may enable fully immersive experiences. Customers can now get real-time price changes, availability, and promotions bypassing third-party distribution platforms. This research note aims to introduce the metaverse’s enormous potential and to define three research proposals for additional investigation.
Associations between executive function and attention abilities and language and social communication skills in young autistic children
Authors: Howard Jill , Herold Brianna , Major Samantha , Leahy Caroline , Ramseur Kevin , Franz Lauren , Deaver Megan , Vermeer Saritha , Carpenter Kimberly LH , Murias Michael , Huang Wei Angel , Dawson Geraldine
Published: February 2023

Although it has been found that autistic children exhibit delays in executive function abilities and atypical patterns of attention, less is known about the relationship between executive function and attention abilities and social and language skills in early childhood. In this study, 180 autistic children, age 2–8 years, participated in a study examining the relationship between executive function abilities, measured by the Behavior Rating Inventory of Executive Function, and assessments of sustained attention measured via eye-tracking and several language and social communication measures. Results revealed that children with higher caregiver-reported executive function skills, specifically, working memory and planning/organization abilities, demonstrated higher levels of caregiver-reported receptive-expressive social communication abilities measured via the Pervasive Developmental Disorder Behavior Inventory. Higher executive function abilities across all domains were associated with lower levels of social pragmatic problems. Children who were able to sustain their attention for a longer duration demonstrated higher expressive language abilities. These results suggest that executive function and attention skills may play an important role in multiple domains of functioning in autistic children. It will be useful to determine whether therapies that seek to improve executive function skills in autistic individuals also positively influence their social/communication and language abilities.

Lay Abstract

Executive functioning describes a set of cognitive processes that affect thinking and behavior. Past research has shown that autistic individuals often have delays in the acquisition of executive function abilities. Our study explored how differences in executive function and attention abilities relate to social abilities and communication/language in 180 young autistic children. Data were gathered via caregiver report (questionnaires/interviews) and an assessment of vocabulary skills. The ability to sustain attention to a dynamic video was measured via eye tracking. We found that children with higher levels of executive function skills demonstrated lower levels of social pragmatic problems, a measure of having difficulties in social contexts. Furthermore, children who were able to sustain their attention longer to the video displayed higher levels of expressive language. Our results emphasize the importance of executive function and attention skills across multiple areas of functioning in autistic children, in particular those that involve language and social communication.
Image-based bolt self-localization and bolt-loosening detection using deep learning and an improved homography-based prospective rectification method
Authors: Xie ChengQian , Luo Jun , Tang KaiSen , Zhong Yongli
Published: February 2023

The bolt loosening detection method has been paid attention by engineering and academic scholars. The presented methods only focus on the identification of the bolt based on deep learning, and the problem of bolt localization and the influence of shadow on distortion correction is seldom studied. In this paper, a bolt self-localization method based on YOLOv4 deep learning algorithm is proposed. A bolt numbering rule is established and the deep learning is introduced to identify the number and locate the bolt. A new square bolt gasket is proposed and four corner points are used for distortion correction. In order to reduce the influence of shadows, a grayscale enhancement strategy is proposed to improve the correction stability. Finally, a laboratory flange joint is used to verify the proposed method. The results show that the bolt self-localization method is feasible and the new bolt gasket can effectively improve the stability of distortion correction and bolt loosening detection.
‘In retrospect’: Object Lessons forum
Authors: Amin Kadji , Nishikawa Kinohi , Rusert Britt
Published: February 2023

Our contribution takes shape as reflections on Object Lessons (Wiegman, 2012) from the perspective of three scholars of race, gender and sexuality who were also graduate students of Robyn Wiegman in the mid-2000s at Duke University. All three of us took Introduction to Feminist Theory with her and all three of us received graduate certificates in Feminist Studies. Our educational and career trajectories also share this similarity: we received PhDs in the disciplines (English, Comparative Literature and French), but went on to jobs that are either completely or partially housed in departments invested in studying what Wiegman calls ‘identity knowledges' (namely, African American Studies and Gender Studies). In these essays, we reflect on how Wiegman's course helped shaped our approaches to academic knowledge production and how her reflexive pedagogy animates not only Object Lessons but also our own critiques of identity’s institutionalized forms.
“Not To Be Taken Personally”: Tracing Six Decades of Scholarship on Personal, Personalist, and Personalized Political Parties (1960–2021)
Authors: Lioy Alberto
Published: February 2023

This article systematically examines the academic literature on personalism and personalization in political parties. Its comprehensive review uses existing studies to (1) demonstrate that personalism has a rich and complex history; (2) outline conceptual differences within the literature related to size, clientelism, internal organization, centralization, and mediatic image; (3) trace patterns of institutionalization and de-personalization of personal parties; and (4) evaluate existing empirical and methodological approaches to the topic. Finally, the conclusion advocates for the adoption of a clear research agenda and proposes conceptual, quantitative, and discursive alternatives to what has already been done.
Outcome Uncertainty and Viewer Demand for Basic Cable Boxing
Authors: Butler David , Butler Robert , Maxcy Joel , Woodworth Simon
Published: February 2023

We examine the uncertainty of outcome hypothesis and consider direct demand for professional boxing using a new dataset for basic cable broadcasts. Our analysis covers 103 broadcasts in the United States from February 2017 to February 2021 for Premier Boxing Champions (FOX) and Top Rank Boxing (ESPN). Using a generalized linear model, we estimate a demand function for basic cable broadcasts and place specific emphasis on adopting alternative measures of outcome uncertainty. We find no evidence that increasing balance between boxers increases viewership figures on basic cable broadcasts. Consistent with pay-per-view boxing viewership, our results demonstrate that bout quality impacts demand for cable broadcasts. Furthermore, we find no evidence of a declining viewership trend, a finding relevant to the industry given the general decrease in viewership trends for main events and pay-per-view broadcasts. Fans continue to demonstrate a preference for the welterweight division.
Lightweight panels with high delamination resistance made of integrally woven truss-like fabric structures
Authors: Vorhof Michael , Sennewald Cornelia , Schegner Philipp , Pham Minh Quang , Hoffmann Gerald , Gereke Thomas , Cherif Chokri
Published: February 2023

Lightweight panels are of high relevance for various applications, such as automotive, aerospace, civil engineering, and achieve high stiffnesses and strengths at low self-weight. The sandwich principle is commonly used to manufacture the panels, although conventional materials and reinforcement structures often limit the design and application of the panels in a wide range of possible applications. The reason for this is that lightweight panels fail either under combined compressive/shear loading or as a result of delamination of the individual layers. In this article, novel fabric structures are presented as a basis for the fabrication of lightweight panels that effectively overcome these deficiencies. These fabrics have a spatial truss-like structure, with the core and top layer being connected by continuously running reinforcing fibers. This results in high panel stability and high delamination resistance, which are evaluated in this article using mechanical tests in compression, flexure and combined tension-shear. The results are related to sample panels with conventional honeycomb core as reference. The high potential and excellent delamination resistance of the new fabric-based lightweight panels is shown in the result of the tests.
Sound transmission loss of absorber-barrier-absorber structures with kapok fibers as absorption layers
Authors: Xie Xin-Xing , Yang Jin-Bao , Kang Ying-Zi , Shangguan Wen-Bin , Zhang Qu
Published: February 2023

The sound insulation of the front wall of a car is mainly used to isolate the noise of the engine from being transmitted to the passenger cabin. A front wall is generally a kind of structure of Absorber-Barrier-Absorber (ABA), where A is sound absorption layer and B is sound insulation layer. The sound absorption layer (A) usually consists of porous cotton of superfine fiber or microfiber. In this paper, kapok fiber is used to make the sound-absorbing layer A, and its sound absorption is compared with that of superfine fiber. Microstructure of the two fibers is compared, and it is found that kapok fiber has a large hollow structure. The sound absorbing coefficients of the layer A made with the two fibers are measured and it is concluded that the layer A made of kapok fibers can absorber noise greatly and thus has high sound absorption coefficient. The prototypes of ABA structural are made using two kinds of fibers as layer A, and the sound transmission loss (STL) was measured using reverberation room and anechoic room. The measurement shows that the ABA using kapok fiber as sound absorption layer has better sound insulations, and the STL of ABA using kapok fiber as sound absorption layer is increased by about 3 dB. A model for estimating STL of ABA structure is established and the calculated STL is validated. Using the developed model, the STL of ABA structures with different structural characteristics of Layers A or B is calculated and analyzed.
See G.I. Jane Run: The Rise of Female Military Veteran Candidates for Congress
Authors: Schroeder Theresa , Best Rebecca , Teigen Jeremy M.
Published: February 2023

Veteran women are better represented in Congress than non-veteran women, but the reasons for this are unclear. Veteran women may be better represented because they run at higher rates and in more winnable races or because their military service leaves them uniquely qualified to overcome gender and partisan stereotypes. Voters often perceive women as lacking leadership ability and ill-suited to handling national security. However, female veterans have experience that may help them overcome gendered beliefs about their abilities. Using election data from the 2012–2020 U.S. congressional elections, we test whether veteran women gain greater voter support compared to non-veteran candidates and whether veteran women running as Democrats outperform male veteran Democrats. We find only limited evidence that military service wins more votes for candidates of either gender. Among Democrats, prior military service levels the playing field between male and female candidates, but veteran women only outperform veteran men in 2018.
Chest Tube Management: Past, Present, and Future Directions for Developing Evidence-Based Best Practices
Authors: Lobdell Kevin W. , Engelman Daniel T.
Published: February 2023

In the field of modern cardiothoracic surgery, chest drainage has become ubiquitous and yet characterized by a wide variation in practice. Meanwhile, the evolution of chest drain technology has created gaps in knowledge that represent opportunities for new research to support the development of best practices in chest drain management. The chest drain is an indispensable tool in the recovery of the cardiac surgery patient. However, decisions about chest drain management—including those about type, material, number, maintenance of patency, and the timing of removal—are largely driven by tradition due to a scarcity of quality evidence. This narrative review surveys the available evidence regarding chest-drain management practices with the objective of highlighting scientific gaps, unmet needs, and opportunities for further research.
3D Printing Technology for Chest Wall Reconstruction With a Sternum-Ribs-Cartilage Titanium Implant: From Ideation to Creation
Authors: Goldsmith Ira , Dovgalski Lawrence , Evans Peter Llewelyn
Published: February 2023

Objective:

We describe the use of 3-dimensional (3D) printing technology to plan and reconstruct the sternum, adjoining cartilages, and ribs with a custom-made, anatomically designed, 3D-printed titanium implant for an isolated sternal metastasis complicated with a pathological fracture.

Methods:

We imported submillimeter slice computed tomography scan data into Mimics Medical 20.0 software and by manual bone threshold segmentation created a 3D virtual model of the patient’s chest wall and tumor. For all-around tumor-free margins, we grew the tumor by 2 cm. The replacement implant was designed in 3D using the anatomical features of the sternum, cartilages, and ribs and manufactured using TiMG 1 powder fusion technology. Physiotherapy was provided prior to and following surgery, and the impact of reconstruction on pulmonary functions was assessed.

Results:

At surgery, the precise resection, clear margins, and a secure fit were achieved. At follow-up, there was no dislocation, paradoxical movement, change in performance status, or dyspnea. There was a decrease in forced expiratory volume in 1 s (FEV1) from 105% prior to surgery to 82% following surgery and in forced vital capacity (FVC) from 108% to 75%, with no difference in the FEV1/FVC ratio, suggesting a restrictive pattern of impairment.

Conclusions:

With 3D printing technology, reconstructing a large anterior chest wall defect with a custom-made, anatomical, 3D-printed titanium alloy implant is feasible and safe, and it preserves the shape, structure, and function of the chest wall, albeit with a restrictive pattern of pulmonary function, which can be addressed with physiotherapy.
Transgender and Nonbinary College Student Inclusivity in Campus Recreation: Perceptions of North American Staff
Authors: Wilson Oliver W. A. , Powers Sammie L. , Frederick Ginny M. , Peterson Keegan T. , Bopp Melissa
Published: February 2023

In this study of North American campus recreation staff, we examined staff perceptions of transgender and nonbinary student inclusivity, and explored differences in perceived inclusivity based on institutional characteristics, policies, amenities, and staff characteristics. Staff were recruited to participate in an online survey that assessed: institutional characteristics, amenities, and policies; personal characteristics; and, their perception of their campus recreation facilities’ inclusivity of transgender and nonbinary students. Perceived inclusivity was greater at nonreligiously affiliated institutions, and at institutions that had antidiscrimination/antiharassment policies and/or all-gender locker/restrooms within the campus recreation department. Men and heterosexual staff reported greater perceived inclusivity than women and sexual minority staff. In summary, antidiscrimination and antiharassment policies and all-gender locker/rest rooms appear to contribute to creating the perception of a more inclusive campus recreation environment. Continued work on staff awareness/knowledge relating to inclusion of transgender and nonbinary students appears to be necessary, and application of policies that support inclusivity should be a priority.
Fluid flow and heat transfer characteristics of Williamson fluids flowing in saturated porous media
Authors: Quran Omar , Maaitah Hussein , Alsabagh Abdel Salam , Elayyan Mutaz , Duwairi Hamzeh M
Published: February 2023

This study was conducted to mathematically evaluate the impact of forced convection of viscous dissipation on a porous media filled with Williamson fluid and exposed to fixed surface heat flux. The technique of Darcy_Forchheimer_Brinkman was employed, then the non-dimensional equations were solved numerically over a flat plate by using bvp4c through the MATLAB package. Different parameters were examined including the profiles of velocity, temperature and shear_stress in addition to Nusselt Number. Furthermore, the study evaluated the effects of several essential parameters, including Forchheimer, Darcy, porous media, Williamson, and viscous dissipation, on the temperature and velocity profiles, heat transfer and friction coefficients. The numerical solution results showed that, under high Forchheimer_parameter values, all, shear_stress, Nusselt_number parameter and temperature showed an increase in their values. Also, as Williamson_parameter increased, the shear_stress and boundary layer velocity were improved, while a decrease in Nusselt_number caused an increased in values of temperature profile. Finally, the boundary layer of velocity and shear_stress showed an increase in their values when Darcy parameter increased. On the other hand, a decrease in the temperature profile and Nusselt_number were observed.
Stabilization effect of dynamic stabilizer with different operation parameters
Authors: Wang Jiongli , Wang Lihua , Huang Hongyi , Chen Taimao , Jiang Wei , Zhao Zemin , Qin Jiwei , Jia Tongpeng
Published: February 2023

Dynamic stabilization operation can effectively improve the mechanical performance of ballast bed by using stabilizer. To improve the stabilization effect, a rigid-flexible coupling dynamics simulation model of the stabilizer-ballast bed system was established according to the actual structure of the stabilizer, and the effect of different operation parameters of stabilizer on the stabilization operation was analyzed. The simulation results showed that: the maximum value of lateral displacement response of the sleeper decreased with the increase in clamping wheel force normal angle, excitation force frequency and downforce; and increased with the increase in excitation force amplitude. The optimized operation parameters were obtained as follows: clamping wheel force normal angle 0°, excitation force frequency 18 Hz, excitation force amplitude 180 kN, downforce 60 kN. A vibration test bench simulating the stabilization operation process was built according to the working principle of the stabilizer, and the reliability of the simulation was verified by testing.
Nonlinear analysis of FRP-concrete-steel solid columns
Authors: Hou Wenyu , Wang Jiaqi , Wang Zhanfei , Huang Fulong
Published: February 2023

In order to study the axial compression performance of the FRP (fiber reinforced polymer)-concrete-steel solid columns (FCSSC), the nonlinear analysis program of FCSSC was compiled in this paper. The program was verified by existing tests, and the impacts of FRP tube thickness, steel tube thickness, outer radius of steel tube, steel tube strength and concrete strength were examined. The outcomes showed that the calculated results agreed with the experimental results. It demonstrated the way that the program could precisely reflect the strain of FCSSC under various degrees of load and gauge a ultimate load of FCSSC. The increment of steel tube thickness, outer radius of steel tube and concrete strength on the bearing capacity of FCSSC were chiefly reflected in the increment of initial stiffness. The improvement of FRP tube thickness could provide greater constraining force. The increment of steel tube strength could expand the load at the inflection point on the load-longitudinal strain curve. The research results can give a reference to the use of the new structure.
Hypogastric artery luminal diameter predicts common-external iliac stent patency and major adverse limb events in patients with aortoiliac occlusive disease
Authors: Smith Andrew H , Dash Siddhartha , Steenberge Sean , Quatromoni Jon G , Rowse Jarrad W , Caputo Francis J , Kirksey Levester , Graham Linda M , Lyden Sean P , Smolock Christopher J
Published: February 2023

Objective

Hypogastric coverage may be required for occlusive disease at the iliac arterial bifurcation. In this study, we sought to determine patency rates of common-external iliac artery (C-EIA) bare metal stents (BMS) spanning the hypogastric origin in patients with aortoiliac occlusive disease (AIOD). In addition, we sought to identify predictors of C-EIA BMS patency loss and major adverse limb events (MALE) in patients requiring hypogastric coverage. We hypothesized that worsening stenosis of the hypogastric origin would negatively influence C-EIA stent patency and freedom from MALE.

Methods

This is a single center, retrospective review of consecutive patients undergoing elective, endovascular treatment of aortoiliac disease (AIOD) between 2010 and 2018. Only patients with C-EIA BMS coverage of a patent IIA origin were included in the study. Hypogastric luminal diameter was determined from preoperative CT angiography. Analysis was performed using Kaplan–Meier survival analysis, univariable and multivariable logistic regression, and receiver operator characteristics (ROC).

Results

There were 236 patients (318 limbs) who were included in the study. AIOD was TASC C/D in 236/318 (74.2%) of cases. C-EIA stent primary patency was 86.5% (95% confidence interval: 81.1, 91.9) at 2 years and 79.7% (72.8, 86.7) at 4 years. Freedom from ipsilateral MALE was 77.0% (71.1, 82.9) at 2 years and 68.7% (61.3, 76.2) at 4 years. Luminal diameter of the hypogastric origin was most strongly associated with loss of C-EIA BMS primary patency in multivariable analysis (hazard ratio: 0.81, p = .02). Insulin-dependent diabetes, Rutherford’s class IV or above, and stenosis of the hypogastric origin were significantly predictive of MALE in both univariable and multivariable analyses. In ROC analysis, luminal diameter of the hypogastric origin was superior to chance in prediction of C-EIA primary patency loss and MALE. Hypogastric diameter >4.5 mm had a negative predictive value of 0.94 for C-EIA primary patency loss and 0.83 for MALE.

Conclusions

Patency rates of C-EIA BMS are high. Hypogastric luminal diameter is an important and potentially modifiable predictor of C-EIA BMS patency and MALE in patients with AIOD.
High-output heart failure following gunshot injury and traumatic arteriovenous fistula
Authors: Palić Benjamin , Mandić Ante , Prskalo Zrinko , Brizić Ivica
Published: February 2023

Background

Heart failure due to high cardiac output rarely occurs. Few cases of post-traumatic arteriovenous fistula (AVF) as a cause of high-output failure were reported in the literature.

Methods

Herein, we report a case of 33-year-old male who was admitted to our institution due to symptoms of heart failure. He reported a gunshot injury of the left thigh 4 months earlier, when he had been shortly hospitalized and discharged 4 days later. Since the gunshot injury he had exertional dyspnea and left leg edema, so the diagnostic procedures were performed.

Results

Clinical examination revealed distended neck veins, tachycardia, slightly palpable liver, left leg edema, and thrill over the left thigh. Due to high clinical suspicion, duplex ultrasonography of the left leg was performed that verified femoral AVF. Operative treatment of AVF was made with prompt resolution of symptoms.

Conclusions

This case wants to emphasize the importance of proper clinical examination, and duplex ultrasonography in all cases of penetrating injuries.
Over-accrual in Bayesian adaptive trials with continuous futility stopping
Authors: Barrado Leandro Garcia , Burzykowski Tomasz
Published: February 2023

Background:

We explore frequentist operating characteristics of a Bayesian adaptive design that allows continuous early stopping for futility. In particular, we focus on the power versus sample size relationship when more patients are accrued than originally planned.

Methods:

We consider the case of a phase II single-arm study and a Bayesian phase II outcome-adaptive randomization design. For the former, analytical calculations are possible; for the latter, simulations are conducted.

Results:

Results for both cases show a decrease in power with an increasing sample size. It appears that this effect is due to the increasing cumulative probability of incorrectly stopping for futility.

Conclusion:

The increase in cumulative probability of incorrectly stopping for futility is related to the continuous nature of the early stopping, which increases the number of interim analyses with accrual. The issue can be addressed by, for instance, delaying the start of testing for futility, reducing the number of futility tests to be performed or by setting stricter criteria for concluding futility.
Transformational leadership and teachers’ voice behaviour: A moderated mediation model of group voice climate and team psychological safety
Authors: Wang Guanghui , Li Jiahui , Liu Hui , Zaggia Cristina
Published: February 2023

Teachers’ voice behaviour has attracted growing attention in universities due to its positive outcomes for institutional reform and improvement. This study investigated how and under what conditions university leaders’ transformational leadership is beneficial to teachers’ voice behaviour using data collected from 434 teachers from universities in China. As a result, we proposed a moderated mediation model of the association between transformational leadership and teachers’ voice behaviour in which group voice climate was used as the mediator and team psychological safety as the moderator. The results revealed evidence of an indirect effect of transformational leadership on teachers’ voice behaviour through the significant mediating role of group voice climate. Moreover, we found evidence that team psychological safety acts as a significant moderator of group voice climate and teachers’ voice behaviour and strengthens the effect of the entire mediating mechanism. Specifically, the mediation effect of group voice climate was significant when team psychological safety levels were at medium or high rather than low levels. Our findings provide a deeper understanding of the benefits and effective mechanism of the impact of transformational leadership on teachers’ voice behaviour in the Chinese university context and offer practical suggestions for facilitating teachers’ voice behaviour in institutions.
Acute stress reduces attentional blindness: Relations with resting respiratory sinus arrhythmia and cortisol
Authors: Kan Yuecui , Duan Haijun , Wang Zhuo , Wang Yining , Liu Saifang , Lan Jijun
Published: February 2023

This study made the first attempt to combine resting respiratory sinus arrhythmia (RSA) and cortisol to provide an explanatory mechanism for the effect of acute stress on emotion-induced blindness (EIB) from the perspective of vagus nerve activity and stress hormone responses. For this purpose, resting electrocardiogram (ECG) signals were recorded first. Participants underwent both the socially evaluated cold-pressor test and control treatments 7 days apart and then completed the EIB task. Heart rate and saliva samples were collected over time. The results demonstrated that acute stress promoted the overall detection of targets. Resting RSA and cortisol levels predicted the stress-induced changes in EIB performance under the negative distractor condition at lag2 negatively and positively, respectively. These findings indicate that the effect of stress on EIB was partially contributed by cortisol, which is more relevant to negative distractor conditions. Resting RSA, as an indicator of inter-individual differences, further provided evidence from the perspective of the trait emotional regulation ability based on the vagus nerve control. In general, resting RSA and cortisol changes over time exhibit different patterns of influence on stress-induced changes in EIB performance. Thus, this study provides a more comprehensive understanding of the effect of acute stress on attentional blindness.
Calculating expected win percentage of an Indian Premier League team
Authors: Hoskins Aaron B
Published: February 2023

The Indian Premier League is the most prestigious cricket league globally. There are significant finances in terms of both team ownership and player salaries. It is, therefore, essential to understanding if a team’s record is due to luck (good or bad) or if a team’s record is due to the team’s overall performance. The research presented here is motivated by how to accurately predict a team’s winning percentage in the Indian Premier League based on underlying statistics. A similar analysis has been done in other sports, mainly based on the concept of the Pythagorean expectation. This research derives a similar model for the IPL based on historical data. However, the structure of a match in the Indian Premier League is fundamentally different than the structure of games in other sports. As a result of this structural difference, this study creates additional models using both least absolute shrinkage and selection operator and stepwise regression to identify variables that are good predictors for calculating the expected winning percentage. These models compare favorably to the Pythagorean expectation model. This article presents a model combining both the determined variables and Pythagorean expectation.
Gastric band slippage in pregnancy: A diagnostic dilemma
Authors: Verstraeten Victoria , Erzeel Jonas , van de Vrande Simon , Scharpé Kathleen
Published: February 2023

Pregnancy after laparoscopic adjusted gastric banding (LAGB) is thought to be safe and lowers the risk for maternal obstetric complications, without causing a difference in birth weight or a higher incidence of neonatal complications. Even though LAGB complications in pregnancy are rare, they are often severe and can cause significant maternal and neonatal morbidity. This report outlines the case of a pregnant 32-year-old female with gastric band slippage in the third trimester and provides a summary of the literature on LAGB complications in pregnancy and their management.
Dual plate fixation of proximal humerus fractures: Retrospective review and surgical technique
Authors: Alqahtani Saad M , Aljamaan Yousef , Abusultan Ammar , Alzahrani Mohammad M
Published: February 2023

Introduction

Recent interest has been directed towards dual plate fixation for comminuted proximal humerus fractures, with an aim to improve construct stability and thus improve patient outcomes while decreasing the risk of fracture-associated complications. We present our experience with this technique in a case series of patients with proximal humerus fractures and describe our surgical technique.

Methodology

This was a single-center retrospective case series of patients presenting with an acute (<6 weeks) proximal humerus fracture who underwent ORIF with dual plating fixation. Patient, fracture, and surgical data were collected. All patient outcomes were evaluated using Constant–Murley shoulder score and Single Assessment Numeric Evaluation.

Results

Our series included nine patients with a mean age of 46.2 years (range: 27–70 years old). All fractures healed within 4 months and no complications were encountered. At 1 year follow-up, the mean SANE score was 69.4% and the mean Constant Murley shoulder score was 78.9 (range: 70–96).

Conclusion

Our current series shows that applying the dual plating technique in severely comminuted proximal humerus fractures provides adequate fixation and thus good patient outcomes. Further research is required before this technique can be strongly recommended for management of these complex fractures.

Level of Evidence

Level 5.