bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH PERSPESI KEMUDAHAN, MANFAAT, RISIKO DAN KEPERCAYAAN TERHADAP EFEKTIVITAS SISTEM INFORMASI AKUNTANSI (Studi Pada Pelaku UMKM Kota Bandung)
Authors: Apriwandi Apriwandi , Christine Debbie , Wijaya Aida , Kartadjumena Eriana , Sherlita Erly , Fathonah Andina Nur
Published: January 2024

This study aimed to determine the interest of small and medium enterprises (SMEs) in using accounting information systems. The interests of SMEs were measured by using the effectiveness of implementing accounting information systems. In addition, behavioral variables were used to bridge the relationship between the perceptions of SMEs on the ease of use, benefits, risks, and trust in the effectiveness of the information system used. The survey method involving a questionnaire was used in this study. The results showed that behavior determines the effectiveness of applying accounting information systems to SMEs. This study also found that it is essential to pay attention to the benefits of the financial accounting system created by the SME company in bringing out a positive attitude from users of accounting information systems.
AKSELERASI GREEN ECONOMY MELALUI DIGITAL SYSTEM ERP DI DESA WISATA KEMIRI KABUPATEN JEMBER
Authors: Salsabila Raissa Aulia , Hasanah Dhaiviatul
Published: January 2024

Every region in Indonesia has the potential to generate income from the tourism sector, especially if it is supported by advances in information technology. However, there is a lot of tourism in Indonesia that has not fully implemented digitalization optimally. Like Kemiri Village in Jember Regency which faces challenges in integrating management and effective marketing. This research aims to optimize the tourism sector in the Kemiri Tourism Village through the implementation of the Digital System Enterprise Resource Planning (ERP). This transformation aims to increase visibility, attract more tourists, and facilitate the management of tourist villages. A qualitative and descriptive research approach was used to comprehensively assess the tourism situation in Kemiri Village. Primary data was collected through interviews with selected communities, as well as direct observation in Kemiri Village, and questionnaires via gform. Secondary data came from documentation, journals and literature. The waterfall method and SMART analysis were also used. Research findings reveal significant untapped tourism potential in Kemiri Village, moreover, integration is still limited. This Digital System Enterprise Resource Planning based website overcomes existing problems by increasing integration between tourist destinations. This website also contributes to the green economy by reducing the use of paper (paperless) through digital transformation in tourism operations.
DAMPAK KOMPENSASI DAN LINGKUNGAN KERJA TERHADAP KEPUASAN KINERJA KARYAWAN: STUDI KASUS PERUSAHAAN START-UP DI PT. GLOBAL TALENTLYTICA INDONESIA
Authors: Krishnabudi Nyoman Gede , Saleh Chairul , Purwanti Gettik Andri , Natalia Princessa
Published: January 2024

This study aims to examine and analyze the effect of compensation and work environment variables on employee job satisfaction partially. The population and sample in this study were 51 respondents who were all employees of PT. Global Talentlytica. This research is classified as explanatory research. Multiple linear regression analysis was applied as data analysis method. The results show that compensation and work environment have a positive and significant impact on employee job satisfaction partially. This indicates that the better the compensation and work environment provided by the PT. Global Talentlytica, the greater the job satisfaction of employees in the company. Compensation and work environment are crucial for companies in maintaining employee job satisfaction.
Dual-fuel engines using hydrogen-enriched fuels as an ecological source of energy for transport, industry and power engineering
Authors: Chojnowski Janusz , Karczewski Mirosław , Szamrej Grzegorz Aleksander
Published: January 2024

Displacing internal combustion engines (ICE) from the passenger car sector does not mean displacing it from all industries and specific applications. Thanks to the analysis of data on compression ignition (CI) engines used in the world, it is possible to prepare ready-made solutions for the most common engines in selected industries or for those whose greenhouse gas emissions will be the largest and most expensive for their owners in the coming years. The basic solution presented in this article gives the possibility of powering the engines with the most ecological currently known alternative motor fuels and using the already existing methane transmission infrastructure around the world. Their greatest advantage is their availability and low carbon content, which allows to minimize carbon dioxide emissions, both by burning hydrogen-enriched fuels and by increasing the efficiency of the engines modified by dual fuel supply system. Properly made external dual-fuel installation allows to improve the thermal efficiency of the CI engine. Work on this issue may help in the development of, for example, high-efficiency flex fuel power generators, which, as the current situation in Ukraine shows, are worthy. Thanks to the diversification of power sources for power generators, the countriesy is able to increase the reliability and security of energy supplies even in difficult conditions, such as armed conflict or natural disasters.
CI:Mor interactions in the lysogeny switches of Lactococcus lactis TP901-1 and Staphylococcus aureus φ13 bacteriophages
Authors: Varming Anders K. , Huang Zhiyu , Hamad Ghofran M. , Rasmussen Kim K. , Ingmer Hanne , Kilstrup Mogens , Lo Leggio Leila
Published: January 2024

Aim: To structurally characterize in detail the interactions between the phage repressor (CI) and the antirepressor (Mor) in the lysis-lysogeny switches of two Gram-positive bacteriophages, the lactococcal TP901-1 and staphylococcal φ13.

Methods: We use crystallographic structure determination, computational structural modeling, and analysis, as well as biochemical methods, to elucidate similarities and differences in the CI:Mor interactions for the two genetic switches.

Results: By comparing a newly determined and other available crystal structures for the N-terminal domain of CI (CI-NTD), we show that the CI interface involved in Mor binding undergoes structural changes upon binding in TP901-1. Most importantly, we show experimentally for the first time the direct interaction between CI and Mor for φ13, and model computationally the interaction interface. The computational modeling supports similar side chain rearrangements in TP901-1 and φ13.

Conclusion: This study ascertains experimentally that, like in the TP901-1 lysogeny switch, staphylococcal φ13 CI and Mor interact with each other. The structural basis of the interaction of φ13 CI and Mor was computationally modeled and is similar to the interaction demonstrated experimentally between TP901-1 CI-NTD and Mor, likely involving similar rearrangement of residue side chains during the formation of the complex. The study identifies one CI residue, Glu69, which unusually interacts primarily through its aliphatic chain with an aromatic residue on Mor after changing its conformation compared to the un-complexed structure. This and other residues at the interface are suggested for investigation in future studies.
Logistic modeling of summer expression of esca symptoms in tolerant and susceptible cultivars in Bordeaux vineyards
Authors: Lecomte Pascal , Bénétreau Céline , Diarra Barka , Meziani Yacine , Delmas Chloé , Fermaud Marc
Published: January 2024

The seasonal dynamics of esca leaf symptom development were monitored and modelled over 10 years (from 2004 to 2006, 2012 to 2014, and 2018 to 2021) in eleven vineyards near Bordeaux (France) and on five cultivars, including three susceptible and two tolerant Field observations performed once or twice a week from the end of May to mid-September confirmed i) the evolution over time of esca leaf symptoms, ii) the presence under the bark of a discolored xylem longitudinal stripe with nonfunctional vessels, and iii) a gradual increase in the number of symptomatic plants within each vineyard. Of the three models tested, nonlinear logistic regression was the best fitting curve, showing a clear and systematic progressive sigmoidal pattern of cumulative esca leaf symptom observations regardless of ‘vineyard*year’ situation. Relationships with climatic data confirmed that all periods of symptom expression corresponded to the warmest and driest period of each vegetative season. Examinations of key dates corresponding to four threshold levels of cumulative incidence of leaf symptomatic vines [S1 (first observed symptoms), S10 %, S50 % and S90 %] showed that tolerant cultivars (Merlot noir and Malbec) generally developed leaf symptoms later than susceptible cultivars (Cabernet-Sauvignon, Cabernet franc, and Sauvignon blanc). A variance analysis and a principal component analysis (PCA) confirmed that compared to susceptible cultivars, tolerant cultivars were associated with increased temperature sums above 10 °C from 1st January, reaching the same symptom thresholds S1 and S10 % and with more cumulative rainfall at the S1 stage. Overall, this study reveals the key role of temperature as a triggering factor for esca symptom expression in relation to fungal activity. The results indicate that the S10 % stage can be used as a discriminant variable to separate cultivars according to their susceptibility. Finally, logistic modelling can be used as a descriptive and analytical tool to study the seasonal dynamics of esca.
Bibliographical Subjects in the Scientific Work of Central Libraries of the Constituent Entities of the Russian Federation
Authors: Lelikova N. K.
Published: January 2024

Bibliography is one of the main areas in the range of scientific specialties of the Higher Attestation Commission in section 5.10 “Art History and Cultural Studies”, specialty 5.4.10 “Library Science, Bibliography and Bibliology”. The article is devoted to the problem of reflecting bibliographic subjects in the scientific activities of the central libraries of the constituent entities of the Russian Federation. The purpose of the article is to consider the problems of creating bibliographic resources, conducting applied scientific research on bibliographic topics and how trends in the development of bibliographic activities of libraries are presented in the publications of specialists. The author concludes that not only conducting bibliographic research itself, but also creating bibliographic resources of various types and genres is scientific work, and libraries rightfully account for their scientific activities by their creation.

By carrying out activities to create bibliographic resources, libraries solve historical and cultural problems: preserving the cultural, historical and scientific heritage of the peoples of Russia through bibliography.

Research activities to study systems for the formation of bibliographic resources in libraries of different types and for bibliographic services to different categories of users are actually bibliographic studies, they are aimed at improving bibliographic activities themselves. By conducting such research, bibliographers determine the prospects for the development of their activities.
Foreign Open Access Journals in the Field of Librarianship: Opportunities for Publishing Research Results
Authors: Volkova I. N.
Published: January 2024

Open access journals are widespread, including the field of library science. The purpose of the article is, basing on the results of the analysis of foreign journals on library science topics, to prepare a list of journals for potential publishing Russian scientists’ articles in them.The selection of journals was carried out on the platforms Directory of Open Access Journals (DOAJ), Dimensions, Lens.org and Scimago Journal & Country Rank. Non-thematic journals were eliminated from the initial sample of journals; the remained ones were analyzed according to the following parameters: reflection of journal data on major world open access resources, indexing in international databases (Web of Science and Scopus), quartile (Q1  и Q2 from Scimago Journal & Country Rank), as well as open access models, price policy and availability of an open license.In addition, the studied journals were checked for presence/absence in the “black” lists of journals. Based on these data, the general “portrait” of library open access journals was compiled and the list of recommended foreign open access journals for publishing the Russian scientists’ results of research was marked out.The study embraced 220 open access journals.The results indicated the Directory of Open Access Journals (57, 7 %) as the main platform for journal selection. About 64 % of journals were free of charge for authors with publishers (universities or associations) covering the costs of publishing articles themselves. “Diamond” (about 63.5% of journals) and “Green” (about 43, 5 % of journals) were identified as the dominant open access models, indexed in Web of Science and Scopus – about 60 % of open access journals.The study also revealed the problem of correct reflection of open access journals on the platforms (discrepancy of topic, type of the document, etc.). The list of 12 highly rated journals that library scientists could use when searching for information and publishing their research results in the open information space was compiled, and analyzed for publications of Russian authors in them over the past 5 years (2018–2023).
The Role of Adjuvant Radiotherapy in the Treatment of Breast Cancer
Authors: Kolářová Iveta , Melichar Bohuslav , Sirák Igor , Vaňásek Jaroslav , Petera Jiří , Horáčková Kateřina , Pohanková Denisa , Ďatelinka Filip , Šinkorová Zuzana , Vošmik Milan
Published: January 2024

The role of postmastectomy radiotherapy and regional nodal irradiation after radical mastectomy is defined in high-risk patients with locally advanced tumors, positive margins, and unfavorable biology. The benefit of postmastectomy radiotherapy in intermediate-risk patients (T3N0 tumors) remains a matter of controversy. It has been demonstrated that radiotherapy after breast-conserving surgery lowers the locoregional recurrence rate compared with surgery alone and improves the overall survival rate. In patients with 4 or more positive lymph nodes or extracapsular extension regional lymph node irradiation is indicated regardless of the surgery type (breast-conserving surgery or mastectomy). Despite the consensus that patients with more than 3 positive lymph nodes should be treated with radiotherapy, there is a controversy regarding the recommendations for patients with one to three involved lymph nodes. In patients with N0 disease with negative findings on axillary surgery, there is a trend to administer regional lymph node irradiation in patients with a high risk of recurrence. In patients treated with neoadjuvant systemic therapy and mastectomy, adjuvant radiotherapy should be administered in case of clinical stage III and/or ≥ypN1. In patients treated with neoadjuvant systemic therapy and breast-conserving surgery, postoperative radiotherapy is indicated irrespective of pathological response.
Bilocal Field Theory for Composite Scalar Bosons
Authors: Hill Christopher
Published: January 2024

We give a bilocal field theory description of a composite scalar with an extended binding potential,

that reduces to the Nambu–Jona–Lasinio (NJL) model in the pointlike limit. This provides a

description of the internal dynamics of the bound state and features a static internal wave-function,

ϕ(⃗r), in the center-of-mass frame that satisfies a Schr¨odinger-Klein-Gordon equation with eigenvalues

m2. We analyze the “coloron” model (single perturbative massive gluon exchange) which yields a

UV completion of the NJL model. This has a BCS-like enhancement of its interaction, ∝ Nc the

number of colors, and is classically critical with gcritical remarkably close to the NJL quantum

critical coupling. Negative eigenvalues for m2 lead to spontaneous symmetry breaking, and the

Yukawa coupling of the bound state to constituent fermions is emergent.
Role of the Alpha-B-Crystallin Protein in Cardiomyopathic Disease
Authors: Thorkelsson Andres , Chin Michael T.
Published: January 2024

Alpha-B-Crystallin, a member of the small heat shock family of proteins, has been implicated in a variety of cardiomyopathies and in normal cardiac homeostasis. It is known to function as a molecular chaperone, particularly for desmin, but also interacts with a wide variety of additional proteins. The molecular chaperone function is also enhanced by signal-dependent phosphorylation at specific residues under stress conditions. Naturally occurring mutations in CRYAB, the gene that encodes alpha-B-crystallin, have been suggested to alter ionic intermolecular interactions that affect dimerization and affect chaperone function. These mutations have been associated with myofibrillar myopathy, restrictive cardiomyopathy, and hypertrophic cardiomyopathy, and promote pathological hypertrophy through different mechanisms such as desmin aggregation, increased reductive stress or activation of calcineurin-NFAT signaling. This review will discuss the known mechanisms by which alpha-B-crystallin functions in cardiac homeostasis and the pathogenesis of cardiomyopathies and provide insight into potential future areas of exploration.
The Relieving Effect of Fermented Pineapple Residue on Heat Stress in Beef Cattle
Authors: Feng Jintao , Yaokun Li
Published: January 2024

In this experiment, the fermented pineapple residue (FPR) was replaced with 0% (CON), 25% (T25) and 50% (T50) in the diet based on silage royal grass roxb for 30 days in the fattened fatten bulls to evaluate the effect of FPR on growth performance, serum indicators and rumen characteristics.Thirty Simmental calves were selected and divided into three groups according to a completely random design.The temperature and humidity of the cowshed shall be measured every day.Rectal temperature and blood of cattle were measured, and blood and immune markers were measured.The results showed that the rectal temperature decreased significantly when adding 25% fermented pineapple residue (P<0.05), and the rectal temperature decreased significantly when adding 50% fermented pineapple residue (P<0.01).The content of T4 and TC in serum of cattle in T50 group was significantly lower than that in the control group (P<0.01), and the content of T3 was significantly higher than that in the control group (P<0.05), and the content of CR was significantly lower than that in the control group (P<0.01). Fermented pineapple residue can indeed improve the oxidative (heat) stress resistance of finishing cattle. In the correlation experiment, bacterial genera such as Succinniclassicum, Melainabacteria, Lachnospiraceae, and Fibrobacteres all showed significant or extremely significant correlations with heat stress-related indicators.
Naturalize Revolution: Unprecedented AI-Driven Precision in Skin Cancer Classification Using Deep Learning
Authors: Abou Ali Mohamad , Dornaika Fadi , Arganda-Carreras Ignacio , Ali Hussein Ahmad , Karaouni Malak
Published: January 2024

Amidst the burgeoning global concerns surrounding skin cancer, the quest for precise and efficient diagnostic methodologies has intensified. Conventional diagnostic approaches relying on subjective visual inspection by dermatologists often grapple with subjectivity and resource constraints. This predicament underscores the critical role of Artificial Intelligence (AI) in revolutionizing diagnostic paradigms by significantly enhancing accuracy and accessibility. This study embarks on an extensive exploration of skin cancer classification, specifically targeting the intricate task of 8-class skin cancer classification. Employing cutting-edge deep learning models on the ISIC2019 dataset, a comprehensive analysis was conducted utilizing a diverse array of pre-trained ImageNet architectures and Vision Transformer models. To counteract the inherent class imbalance in skin cancer datasets, a pioneering "Naturalize" augmentation technique was introduced, leading to the creation of indispensable tools—the Naturalized 2.4K ISIC2019 and groundbreaking Naturalized 7.2K ISIC2019 datasets—catalyzing advancements in classification accuracy. The pivotal role of AI in mitigating the risks of misdiagnosis and under-diagnosis in skin cancer becomes evident through this research. AI’s proficiency in analyzing vast datasets and discerning subtle patterns augments the diagnostic prowess of dermatologists significantly. Integration of AI-powered systems in skin cancer diagnosis holds immense promise in facilitating early detection and substantially improving patient outcomes. The meticulous evaluation employed quantitative measures such as confusion matrices, classification reports, and visual analyses using Score-CAM across diverse dataset variations. Astonishingly, the culmination of these endeavors culminated in an unprecedented achievement—100% average accuracy, precision, recall, and F1-Score—within the groundbreaking Naturalized 7.2K ISIC2019 dataset. This remarkable feat underscores the transformative potential of AI-driven methodologies, exemplifying their prowess in redefining the landscape of skin cancer diagnosis and management. In summary, this research represents a pivotal stride towards redefining dermatological diagnosis, showcasing the remarkable impact of AI-powered solutions in surmounting the challenges inherent in skin cancer diagnosis. The attainment of 100% across crucial metrics within the Naturalized 7.2K ISIC2019 dataset serves as a testament to the transformative capabilities of AI-driven approaches in reshaping the trajectory of skin cancer diagnosis and patient care.
Effects of Shot Peening Treatment on the Properties of Additive and Conventionally Manufactured Ti6Al4V Alloy: A Review
Authors: Okuniewski Wojciech , Walczak Mariusz , Szala Mirosław
Published: January 2024

Literature review indicates that the basic microstructure of Ti-6Al-4V is bimodal which consist of two phases: α + β, and it occurs after the fabrication in conventional methods such as casting, plastic forming or machining processes. After the additive manufacturing methods, there could be significant changes in the microstructure. Due to the rapid heat exchange during heat-treatment process, bimodal microstructure transforms into lamellar microstructure which consists of two phases α′ + β. Despite applying optimum printing parameters, 3D-printed products exhibit typical surface defects and discontinuities. Recently, two of the primary technologies for the improvement of surface layer properties of titanium alloys are shot peening and electropolishing. Literature review signalizes that shot peening and electropolishing processes have positive impact on the corrosion behaviour, mechanical properties and the condition of the surface layer of titanium alloy. Furthermore, there is a lack of studies about combining shot peening and electropolishing in one hybrid process on titanium alloys, which could synthesize the benefits of both processes. The scope of future investigation is also included in this review.
IoTwins: Implementing Distributed and Hybrid Digital Twins in Industrial Manufacturing and Facility Management Settings
Authors: Bellavista Paolo , Modica Giuseppe Di
Published: January 2024

A Digital Twin (DT) refers to a virtual representation or digital replica of a physical object, system, process, or entity. This concept involves creating a detailed, real-time digital counterpart that mimics the behavior, characteristics, and attributes of its physical counterpart. DTs have the potential to improve efficiency, reduce costs, and enhance decision-making by providing a detailed, real-time understanding of the physical systems they represent. While this technology is finding application in numerous fields, such as energy, healthcare, transportation, it appears to be a key component of the digital transformation of industries. In this paper, we present the research results achieved by IoTwins, a European research project aimed at investigating opportunities and issues of adopting DTs in the fields of industrial manufacturing and facility management. Particularly, we discuss a DT model and a reference architecture for use by the research community to implement a platform for the development and deployment of industrial DTs in the cloud continuum. Guided by the devised architectures’ principles, we implemented an open platform and a development methodology to help companies build DT-based industrial applications and deploy them in the so-called Edge/Cloud continuum. To prove the research value and the usability of the implemented platform, we discuss a simple yet practical development use case.
Comparison of In-Vitro Bacterial Susceptibility to Common and Novel Equine Wound Care Dressings
Authors: Simpson Merrill , Hendrickson Dean , Hyatt Doreene , Rao Sangeeta
Published: January 2024

The goal of this study was to determine the relative susceptibility of four common equine wound pathogens to ten different types of antimicrobial agents based on minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Additionally, to describe the comparison of bactericidal activity of medical grade Manuka honey, local honey, and commercial, food-grade honey to other commonly used wound dressings. The objective is to provide veterinary practitioners with comparative data on the use of a variety of antimicrobial dressings for inhibiting growth of common wound bacteria. MIC and MBC for Manuka, store, and local honeys were comparable to those of sterile gauze, sugar, and hypertonic saline. Across bacterial species, local honey proved to have more bactericidal activity when compared to Manuka and commercial, food-grade honey. The MIC and MBC for PHMB gauze and foam was consistently at a higher dilution compared to the other antimicrobials. The majority of antimicrobials exhibited stronger inhibitory and bactericidal activity against a Streptococcus zooepidemicus isolate obtained from a wound compared to other bacteria that were ATCC lab acclimated. Additional research for in-vivo applications needs to be done to see whether differences exist in effective wound management.
Validating Enteroid-Derived Monolayers From Murine Gut Organoids for Toxicological Testing of Inorganic Particles: Proof-of-Concept With Food Grade Titanium Dioxide
Authors: Malaisé Yann , Casale Eva , Pettes-Duler Aurélie , Cartier Christel , Gaultier Eric , Martins Breyner Natalia , Houdeau Eric , Evariste Lauris , Lamas Bruno
Published: January 2024

Human exposure to foodborne inorganic nanoparticles (NPs) is a growing concern. However, identifying potential hazards linked to NP ingestion often requires long-term exposure in animals. Owing these constraints, intestinal organoids are a promising alternative to in vivo experiments, as such an in vitro approach should enable rapid and reliable assessment of the effects on the gut of ingested chemicals. However, this remains to be validated for inorganic substances. In our study, a transcriptomic analysis and immunofluorescence staining were performed to compare the effects of food-grade TiO2 (fg-TiO2) on enteroid-derived monolayers (EDMs) from murine intestinal organoids to known impacts of TiO2 on intestinal epithelium. After validating their ability to dose-dependently respond to a pro-inflammatory cytokine cocktail, EDMs were exposed to 0.1, 1 or 10 µg fg-TiO2/mL for 24h. In line with known data, a dose-related increase of muc2, vilin 1 and chromogranin A gene markers of cell differentiation was observed. In addition, fg-TiO2 induced apoptosis and dose-dependent genotoxicity, while a decreased expression of genes encoding for antimicrobial peptides, and of genes related to tight junction function was observed. These results validated the use of EDMs as a reliable model for toxicity testing of foodborne NPs likely to affect the intestinal barrier.
Canine Leishmaniasis in a Recent Endemic Region in Southern Brazil
Authors: Fraga Aline Padilha de , Silveira Vinicius Proença da , Salla Patrícia de Freitas , Goulart Fernanda Gass de Oliveira , Streck André Felipe , Pereira Vagner Reinaldo Zingalli Bueno , De Mello Lauren Santos , Fonseca André Salvador Kazantzi , Ikuta Nilo , Lunge Vagner Ricardo
Published: January 2024

Leishmania infantum is an hemopathogen of importance for the health of domestic dogs (Canis lupus familiaris), causing canine leishmaniasis (CanL), as well as it is the etiological agent of human visceral leishmaniasis (HVL). This parasite was not reported in southern Brazil until the early 2000s, but CanL and HVL were increasingly reported in the last 15 years, mainly in cities bordering Argentina. The present study aimed to detect L. infantum in urban dogs and to determine the main clinical manifestations in the infected animals from Uruguaiana, a city with a high incidence of CanL. Fifty-one dogs suspected of having CanL in the urban perimeter of the city were clinically examined by veterinarians and investigated for the occurrence of L. infantum with two immunoassays (rapid chromatography test and ELISA) and real-time PCR. Clinical signs were compared in positive and negative L. infantum animals. A total of 31 dogs (60.8%) were infected with L. infantum. The main clinical manifestations associated to CanL dogs were onychogryphosis and peeling (p<0.05). L. infantum was frequently detected in urban dogs from Uruguaiana, highlighting the health concerning situation in this city. The occurrence of some clinical signs (onychogryphosis/peeling) could help to detect more frequently CanL in the canine population.
Enterococci in Ruminant Carcasses at a Slaughterhouse: Prevalence, Virulence Factors and Antibiotic Resistance in Turkey
Authors: Cebeci Tugba
Published: January 2024

Enterococci are widely acknowledged as prominent pathogens in hospitals, with the potential to transfer resistance genes, virulence factors, or other characteristics that increase their ability to survive in humans. The objective of this study was to determine the prevalence and diversity of Enterococcus species in healthy sheep, goat, and cattle carcasses, as well as to analyze the antimicrobial resistance phenotype/genotype and the virulence gene content. During 2019–2020, carcass surface samples of 150 ruminants were collected in a slaughterhouse. A total of 90 enterococci, comprising 5 species, were obtained. The overall prevalence of enterococci was found to be 60%, out of which 37.7% were identified as E. hirae, 33.3% as E. casseliflavus, 15.5% as E. faecium, 12.2% as E. faecalis, and 1.1% as E. gallinarum. Virulence-associated genes of efaA (12.2%) were commonly observed in the Enterococcus isolates, followed by gelE (3.3%), asaI (3.3%), and ace (2.2%). Characteristic resistance genes were identified by PCR with an incidence of 6.6%, 2.2%, 1.1%, 1.1%, 1.1%, and 1.1% for the tetM, ermB, ermA, aac(6’)Ie-aph(2")-la VanC1, and VanC2 genes, respectively. The high resistance to quinupristin-dalfopristin (28.8%), tetracycline (21.1%), ampisilin (20%), and rifampin (15.5%) was distributed among two, four, four, and five of the five species, respectively. The resistance of Enterococcus isolates to 11 antibiotic groups was determined and multidrug-resistant (MDR) strains occupied 18.8% of the Enterococcus isolates. The study's results showed that there were enterococci in the slaughterhouse that were multidrug resistant (MDR) and had a number of genes linked to virulence that could be harmful to human health.
Ensuring Financial Wellness in Healthcare: Unveiling Challenges and Seizing Opportunities in Hospital Management Accounting for Sustainable Success
Authors: Almeida Marques Paula Cristina , Oliveira Paulo Alexandre , Barbosa Sofia Nair
Published: January 2024

The efficient and sustainable management of hospitals is an increasingly relevant challenge in the healthcare sector. With limited financial resources, regulatory pressures and increasing demands for quality services, hospitals are faced with the want to approve sound policies to certify financial and operational sustainability. Management accounting is critical in this instance. In Portugal the DL nº 284, of July 26, 1999, allow us to confirm the need to reinforcement of profitability and efficiency in the provision of healthcare. Management accounting is an essential tool for monitoring and controlling costs, making strategic decisions, efficiently allocating resources and evaluating performance in the hospital environment. It allows a comprehensive view of financial and operational aspects, providing valuable information for management and strategic planning. However, the sustainability of hospital management accounting is a critical and complex topic that deserves special attention. Hospitals face several challenges, such as the complexity of hospital costs, the integration of information systems and the measurement of healthcare value. These challenges can compromise the effectiveness of management accounting and its ability to provide relevant and reliable information for decision making. As a result, it is required to address the sustainability of hospital management accounting by identifying the specific challenges faced in this area and exploring opportunities to overcome them. By addressing these challenges and seizing opportunities, hospitals can strengthen their position in the healthcare sector, improve their operational efficiency, optimize resource allocation and ensure the provision of quality services to patients. In this article, the challenges faced by hospital management accounting will be analysed, such as the complexity of costs, the integration of information systems and the measurement of value in healthcare. Additionally, opportunities to improve financial and operational management will be highlighted through the adoption of advanced technologies, an emphasis on value-based management and collaborative partnerships. By exploring these themes, this essay aims to make a contribution. to the advancement of hospital management accounting and the sustainability of hospitals in the current healthcare scenario.
Discrete Event Systems Theory for Fast Stochastic Simulation via Tree Expansion
Authors: Zeigler Bernard. P
Published: January 2024

Paratemporal methods based on tree expansion have proven to be effective in efficiently generating trajectories of stochastic systems. However, combinatorial explosion of branching arising from multiple choice points presents a major hurdle that must be overcome to implement such techniques. In this paper we tackle this scalability problem by developing a systems theory-based framework covering both conventional and proposed tree expansion algorithms for speeding up discrete event system stochastic simulations while preserving desired accuracy. An example is discussed to illustrate the tree expansion framework in which a discrete event system specification (DEVS) Markov stochastic model takes the form of a tree isomorphic to a free monoid over the branching alphabet. We derive the computation times for baseline, non-merging, and merging tree expansion algorithms to compute the distribution of output values at any given depth. The results show the remarkable reduction from exponential to polynomial dependence on depth effectuated by node merging. We relate these results to the similarly reduced computation time of binomial coefficients underlying Pascal’s triangle. Finally, we discuss application of tree expansion to estimating temporal distributions in stochastic simulations involving serial and parallel compositions with potential real world use cases.
Fast Joule Heating for Scalable and Green Production of Graphene with a High Surface Area
Authors: Evseev Zakhar Ivanovich , Prokopiev Aisen Ruslanovich , Dmitriev Petr Stanislavovich , Loskin Nikolay Nikolaevich , Popov Dmitrii Nikolaevich
Published: January 2024

The rapid development of electric vehicles, unmanned aerial vehicles, and wearable electronic devices has led to a high interest in research related to the synthesis of graphene with a high specific surface area for energy applications. However, the problem of graphene synthesis scalability, as well as the lengthy duration and high energy intensity of the activation processes of carbon materials, are significant disadvantages. In this study, a reactor was developed for the green, simple, and scalable electrochemical synthesis of graphene oxide with a low oxygen content of 14.1 %. The resulting material was activated using a fast joule heating method. The processing of mildly oxidized graphene with a high–energy short electrical pulse (32 ms) made it possible to obtain a graphene–based porous carbon material with a specific surface area of up to 1984.5 m2/g. The low energy intensity, simplicity, and use of environmentally friendly chemicals render the proposed method scalable.
Ultrathin Encapsulation Strategies with Predefined Gate Dielectric Surface Area for Flexible Crystalline Silicon Nanomembrane Based MOS Capacitors
Authors: Wang Zhuofan , Lu Hongliang , Zhang Yuming , Liu Chen
Published: January 2024

Crystalline silicon nanomembrane (Si NM) is promising in wearable and implantable bioelectronics due to its electrical and mechanical performances. However, the current explorations are not enough to firmly bridge ultrathin encapsulation strategies with high performance crystalline Si NM based transistors. In this work, we utilized Al2O3/alucone as the ultrathin encapsulation strategies aim to thoroughly investigate the effect of gate dielectric surface area on the electrical performance of crystalline Si NM based metal-oxide-semiconductor capacitors (MOSCAPs). The comparative analysis was implemented on the three types of diameters (Ø) MOSCAPs with and without Al2O3/alucone encapsulation under planar and concave/convex bending conditions. Benefited from the Al2O3/alucone ultrathin encapsulations, the stability of gate leakage current density, and interfacial characteristics were maintained and improved under mechanical bending deformations for MOSCAPs with predefined Ø of 160, 240, and 320 μm compared to the bare MOSCAPs. Combined with the Ø-related mechanical analysis on the maximum strain in the critical layers and the practical measurements, the encapsulated MOSCAPs with Ø 160 μm showed the most stable electro-mechanical performances. The variations for encapsulated MOSCAPs with three types of Ø emerged in the oxide layer and the interface at dielectric/Si NM that were carefully evaluated according to the bending deformations. These findings are significant for leveraging the practical applications in the ultrathin encapsulation strategies for reliable operations of crystalline Si NM based integrated circuits (ICs).
Impaired Regulation of Emotion in Bipolar Disorder: Behavioral and Neurophysiological Signatures
Authors: Carminati Mathilde , Isel Frédéric , Houenou Josselin , Wessa Michèle , Henry Chantal
Published: January 2024

Patients with bipolar disorder (BD) experience more frequent and intense emotions in response to environmental conditions relative to healthy subjects, which leads to mood instability. The aim of this study was to investigate the time-course of emotion regulation strategies, distraction, and reappraisal, in euthymic BD patients using electroencephalography (EEG). Fourteen BD patients and 13 matched healthy controls took part in an experiment constituted of three conditions, i.e., a passive viewing of positive, negative, and neutral pictures and two regulation conditions, one with reappraisal strategy and the other with distraction strategy. Critically, ERP results indicated that during passive viewing, the Late Positive Potential (LPP) was larger in BD patients compared with healthy controls, but only for neutral pictures. During emotion regulation, LPP amplitude was reduced in distraction condition compared with viewing one, especially for negative emotions in both patients and controls. Importantly, LPP was reduced in reappraisal condition compared with passive viewing in an early time window for negative emotions and in a later time window for positive emotions in controls but not in patients. Our findings showed that the neurochronometry of emotion regulation is faster for negative than for positive emotion in controls but not in BD patients.
Master Regulators of Vigilance and Stress Response: The Intricate Involvement of Orexin/Hypocretin Neuropeptides in Physiology and Behavior
Authors: Jászberényi Miklós , Thurzó Balázs , Bagosi Zsolt , Vécsei László , Tanaka And Masaru
Published: January 2024

The orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific research following the discovery that this family plays a crucial role in a variety of physiological and behavioral processes. These neuropeptides serve as powerful neuromodulators, intricately shaping autonomic, endocrine, and behavioral responses across species. Notably, they serve as master regulators of vigilance and stress responses; however, their role in complex processes such as food intake, metabolism, and thermoregulation warrant further investigation. This narrative review provides a journey through the evolution of our understanding of the orexin system, from its initial discovery to the promising progress made in developing orexin derivatives. It goes beyond conventional boundaries, striving to synthesize the multifaceted activities of orexins. Special emphasis is placed on domains such as stress response, fear, anxiety, and learning, in which the authors contributed to the literature with original publications. This article demonstrates the orchestrating role of the orexins in several intricate and integrative physiological processes. It also overviews the advancement of orexin pharmacology, which has already yielded some promising successes, particularly in the treatment of sleep disorders. This interdisciplinary approach to studying neuropeptides unveils their significance as vital connectors between transient functional changes and lasting structural adaptations. Ultimately, it advances our understanding of the intricate physiological and behavioral contributions of the orexin/hypocretin neuropeptide family.
Rapid Review on the Concept of Positive Health and Its Implementation in Practice
Authors: Van Vliet Marja , De Kleijn Miriam , Van den Brekel Karolien , Huijts Tim , Hogen-Koster Sandra van , Jung Hans Peter , Huber Machteld
Published: January 2024

Positive Health (PH) has been described as a promising transformative innovation to address the challenges of promoting well-being and reducing the burden of disease. The aim of this study is to review the current state of knowledge about PH as introduced by Huber et al. (2016) within the available scientific literature. A rapid review of the literature following the Cochrane Rapid Review recommendations. Three databases were searched (PubMed, Google Scholar, and CINAHL). Data were extracted and synthesized using a narrative approach. A total of 55 articles were included. Initial evaluation studies reveal promising results both at individual and collective levels. However, a need is expressed in several articles for further refinement of the conceptualization of PH and ways to make the effects of the PH approach more measurable. Professionals also expressed a desire for a more informed application and elaboration of the PH method across various settings and populations to enhance its effectiveness in practice. This rapid review highlights the transformative potential of PH in shifting from a disease-focused to a health-oriented paradigm of healthcare. It underscores the need for continued research regarding further development of the concept and its practical method, along with the necessity for methodological innovation.
A Modified Aeromagnetic Compensation Method Robust to In-Cabin OBE Interferences
Authors: Liu Yuxin , Li Wen , Wei Dongyan , Shen Ge
Published: January 2024

Aeromagnetic compensation plays a vital role in geomagnetic navigation and has received considerable attention throughout last few decades. Classical aeromagnetic compensation methods based on the Tolles–Lawson (T-L) model are mainly aimed at permanent, induced, and eddy-current magnetic interferences of aircraft platform, which ignores other stray magnetic field interference on the platform including the interferences caused by on-board electronic (OBE) systems. In order to cooperate with TL model, magnetometers are usually required to be installed on the extension rod outside the cabin, which is widely applied to geophysical magnetic survey. In order to ensure safety and reduce the cost of platform modification in geomagnetic navigation, it’s necessary to place magnetometers inside the cabin. It also further exacerbates the magnetic interferences and improves the difficulty of magnetic compensation. In this paper, a modified aeromagnetic compensation method is proposed, and the in-cabin OBE interferences are respectively modelled to be proportional to the currents and their temporal variations of different electronic devices. To ensure that modified model adapts to strong OBE interference in the cabin, a cut-off frequency determination method based on curvature calculation and a feature selection method based on correlation calculation are proposed. The cut-off frequency determination method helps to select passband filter which suitable for in-cabin OBE interference. The feature selection method can help to effectively select current and voltage inputs for modified model. In addition, principal component analysis (PCA) is adopted to reduce multicollinearity which is intensified by the extension of OBE interferences in coefficient-estimating. Experiments on public dataset are conducted to illustrate the effectiveness of the proposed method, and the best compensation result achieved 1.71nT of root mean square error (RMSE).
DINAMIKA PENGGUNAAN RUANG CAR FREE DAY OLEH KOMUNITAS PECINTA HEWAN KOTA SURAKARTA STUDI KASUS JALAN BRIGJEN SLAMET RIYADI TAHUN 2010 – 2018
Authors: Gusti Gending , Sarwono Sarwono , Yusup Yasin
Published: January 2024

The existence of animal lovers community when the CFD of Surakarta City produced their community gathering spaces with other animal lovers communities. From 2010 to 2018 these spaces experienced a dynamic. This study aims to: (1) determine the process of production of space carried out by the animal lover community in the Surakarta City CFD (2) determine the development of production of space carried out by the animal lovers community in the City of Surakarta CFD in 2010 to 2018. The research method used in this study is a qualitative method. The research approach in this study is a spatial descriptive approach and regressive approach. Based on the results of the study it can be concluded that: (1) The gathering space of animal lover communities in Surakarta City CFD was created because it was initiated by the participation of these animal lovers communities in CFD to result in social interaction. Animal lovers community practicing spatial practice in CFD. Animal lover communities arrange in such a way as the arrangement of the gathering space of each community (conceived space) using supporting attributes such as using MMT, x-banner, cage, perch and community uniforms that create new spaces of representation. (2) The spaces created by the animal lovers community from 2010 to 2012 occupy random spaces, in 2018 a permanent pattern has been seen in one location and lined up in front of the Surakarta District Court.