bluuebunny/crossref_metadata_2025 huggingface dataset:
Donkere wolken boven de Bel-20
Authors: Nicaise Laurent
Published: March 2021

Cet article a pour but d'analyser l'emploi de métaphores météorologiques dans la presseéconomique et leur impact sur la propension à investir en actions cotées en bourse. Cetteétude lie une analyse de corpus d'une série de concepts financiers à une expérience visantà explorer effet (négatif) sur le comportement des investisseurs lorsque les journalisteséconomiques emploient des métaphores météorologiques. Les résultats démontrent (1)que les métaphores météorologiques sont relativement fréquentes mais nettement moinsque les métaphores de SANTÉ, MOBILITÉ et COMBAT, (2) que leur emploi dépend de préférencesidéologiques et (3) que des concentrations plus élevées de métaphores météorologiquesdiminuent la propension à acheter des actions. L’expérience permet de conclureque les indicateurs financiers objectifs sont concurrencés par le pouvoir rhétorique de lamétaphore dans la prise de décisions financières.
Het modern taalkundig concept van de intonatie-eenheid in de Laat Middeleeuws Griekse πολιτικος στιχος poëzie
Authors: Soltic Jorie
Published: March 2021

In this article, I hope to strengthen the case that the study of so-called dead languages canbenefit from modern linguistic theory. More concretely, I show that we can apply themodem linguistic concept of the intonation unit, which is a theoretical notion fully developedon the basis of contemporary spoken (!) languages, to the Late Medieval Greekπολιτικος στιχος poetry (12th - 15th century). This type of poetry is conceptually made upof short, simple, "chunks" of information. More precisely, each verse consists of two(stylized) intonation units, demarcated by the fixed caesura, which can thus be equatedwith an Intonation Unit boundary. This thesis is supported by various arguments, both ofa metrical (e.g. avoidance of elision) and of a syntactico-semantic nature (e.g. position ofthe P2 particles).
Mystieke antropologie in het zestiende-eeuwse traktaat Vanden tempel onser sielen
Authors: Van Nie Renske
Published: March 2021

This article discusses the mystical anthropology in the 16th-century mystical Dutch treatiseThe Temple of Our Souls. This book was published a s apart of the Catholic Reformation.The allegedly female author of the Temple has remained anonymous. The Templedescribes the human being in his immediate relationship to God. Based on the structureof the liturgy and with a positive portrayal of mankind, the text focuses on the obligatoryand successive states in the path to mystical union with God through Christ. Among themost important anthropological concepts are the tripartition of man in body, soul andspirit, as well as the 'ground' of the soul, through which mystical union is possible.
"Dit navolghende sijn sermoenen ende es wat verclaers vanden gheboden gods"
Authors: Blokker Lisette
Published: March 2021

ln 1463, an anonymous Dominican preached thirty-one Middle Dutch Decalogue-sermonsin Ghent. The Ten Commandments are extensively explained in those sermons,which were written down by an industrious auditor. In this article, the context andintended public of both the original, oral sermons and the written, re-constructed sermonsare examined. It appears they were intended for laymen, probably members of the uppermiddleclass; the language and content of the sermons indicate this, as well as manuscriptfeatures such as the luxurious binding. This is also supported by the context of the sermons,specifically the Middle Dutch preaching and Decalogue traditions, and the activityof the Dominicans in Ghent.
Metonymie is geen stijlfiguur: metonymie is overal
Authors: Sweep Josefien
Published: March 2021

Examples of metonymy in lexicons on literature have nothing to do with literary sentencesin which a figure of speech is used. Linguists have become aware that metonymyaffects normal language in many different ways: Not only the meaning of lexical wordscan be metonymical, but grammar also shows many metonymical shifts. This article providesan overview of many metonymical influences and it shows the importance of connectingliterary studies with linguistic ones.
Byzantijnse boekepigrammen / metrische parateksten
Authors: Meesters Renaat
Published: March 2021

This article presents some theoretical reflexions on book epigrams, which are alsoreferred to as metrical paratexts. The article focuses on terminology and the classificationof book epigrams. Two different ways of classification are compared: classificationaccording to function (e.g. colophon verse, laudatory and dedicatory epigram) and classificationaccording to preservation (traditional, editorial and post-editorial paratexts).Some of these categories, however, overlap, as will be shown by both Byzantine andmodem examples.
"Gardez-vous-en bien ... de la brochure"
Authors: Van Dam Michiel
Published: March 2021

At the end of the eighteenth century, the Austrian Netherlands were plagued by politicalturmoil and social upheaval, brought forth by a reaction against the reformatory movementset up by the Habsburg government. The contestation of Joseph II's reformist policywas performed in public, as the region was flooded with polemical pamphlets, ideologicaltreatises and many other types of popular writings during (but also before and after) theperiod of the Brabant Revolution (1787-1789). Pamphlets have stood at the centre ofattention for historiography on Belgian political culture at the end of the ancien régime,yet this wide employment of the source material has not led to a comparative overview ofthe way these writings have been used in historical research. This article will attempt tofill this gap, by first providing a methodological typology of several historiographicaluses of a particular pamphlet, the Manifeste du Peuple Brabançon, written at the end of1789, and signed by the leader of the conservative opposition, Hendrik Van der Noot.Secondly, I will attempt to show how eighteenth-century pamphleteers used a multitudeof discourses at their disposal, by briefly discussing another set of (pre-revolutionary)pamphlets. This has immediate consequences for the current understanding of eighteenth-centuryBrabant political culture, which, so I argue, should not be considered discursivelymonolithic (containing one political language) but pluralist (containing multiple politicallanguages).
Praet, Bronkhorst en Boetzelaer
Authors: Valkeneers Nina , Soen Violet
Published: March 2021

Recently, historiography on early modem France has established the crucial roleof noblewomen - and particularly of no bie widows - in propagating the CalvinistFaith during the sixteenth-century Wars of Religion. This article unravels this verysame phenomenon for the Habsburg Low Countries, concentrating on the eve andthe aftermath of the Iconoclastic Fury in the year 1566. After the death of their husbands,the related noblewomen Petronella van Praet-Moerkerken, Catharina van Bronckhorst-Batenburg and Catharina van Boetzelaer became influential and instrumental inspreading Calvinism in their dominions, even when the Habsburg government took specificmeasures to prohibit their support for the 'new religion' and tried to interfere in theseigniorial administration. The Iconoclastic Fury certainly enabled these three noblewomento perform activities which were not normally ascribed to their gender, such asoffering shelter for coreligionists and organizing religious resistance and even iconoclasm.Compared with their spouses and male siblings defending their confession inleagues and battles, however, their action radius as women seems to have been confinedchiefly to the limits of their lordships.
Blauwe energiepillen slikken
Authors: Martens Reuben
Published: March 2021

Problems of energy are an interesting recurring theme in the cinematic works of TheWachowski’s, who seem to be fascinated with the consumption of human bodies. TheMatrix-trilogy is perhaps the most interesting in that respect, as it actively deals withissues of human energy, both literal and metaphorical. However, this problematic dialecticof human energy is not easily understood. Moreover, it requires a completely new andradical interpretation of the films altogether. This article will utilise a machinic-orientedontology to explore the energy issues at stake in The Matrix and what these issues mayteach us about our own understanding of the energy problems that we have encounteredat the dawn of the Anthropocene.
Hybriditeit in de galante brief
Authors: Van Assche Astrid
Published: March 2021

Cet article se concentre sur les manifestations d’hybridité littéraire dans la correspondancegalante de la première moitié du XVIIe siècle produite au sein du salon mondainHôtel de Rambouillet (1608-1661). Nous regarderons plus spécifiquement les hybriditésidentitaire, générique et dialogique dans les lettres galantes d’entre autres VincentVoiture (1597-1648), Charles Cotin (1604-1681) et Antoine Godeau (1605-1672). Ce casd’étude tripartite pointe l’hybridité littéraire comme témoin et catalyseur des évolutionsdans le champ littéraire de l'époque.
Ovidiaanse kalenderpoëzie ten dienste van het christendom
Authors: Nelis Tilke
Published: March 2021

The Roman poet Publius Ovidius Naso (1st c. BC - 1st c. AD) is the author of a work bearingthe title Fasti. This poem, a description of the Roman calendar in elegiacs, has influencedmany poets throughout the ages. During the Renaissance, for example, the genreof the Neo-Latin calendar poem saw the light of day. The sixteenth-century ltalianhumanist Ambrosius Novidius Fraccus belongs to this tradition with his masterpiece theSacri Fasti, which aims to be a Christian counterpart of the ancient Fasti. A thoroughanalysis of a few passages from the Sacri Fasti can shed light on both the Ovidian characterand the Christian interpretation of this quite intricate work.
Leve de foetus
Authors: Gijbels Jolien
Published: March 2021

This article discusses how Belgian doctors dealt with religious beliefs in their medicalpractice in the nineteenth century, using the medical discussion of the cesarean section asa case study. In this period doctors faced a dilemma as cesareans were highly mortal forwomen and other altemative operations had fatal consequences for the fetus. Whereasmost Catholic physicians preferred the cesarean section, liberal practitioners often saw noharm in sacrificing the unborn fetus in order to save the mother. By analyzing the argumentsand codes of conduct of Belgian doctors I will show how they demarcated boundariesbetween religious beliefs and their medical practice.
Vlaamse naoorlogse literaire tijdschriften (1944-1950), van institutioneel overzicht naar discursieve verdieping
Authors: Van Steen Maxime
Published: March 2021

In Flemish literary history, it is generally understood that the cultural (youth) periodicalspublished briefly after the liberation (1944-1950) played a considerable role in the elaborationof the post-war literary field (Brems & De Geest 1988, 10). Nonetheless, thisinteresting thesis has not lead to an in-depth investigation of these periodicals. This lackof interest can be ascribed to: (1) statements of academics on the bad quality of the primarytexts, (2) the incomplete periodical archive and (3) the size of the corpus. In this article,I will present a workable proposal to study these post-war periodicals, despite theseobjections, building on a comprehensive outline of the strongly revalued (inter)nationalresearch on literary periodicals.
Zingende gemeenschappen: politieke liederen en gemeenschapsvorming in de Noordelijke Nederlanden rond 1800
Authors: Vulto Renée
Published: March 2021

Early modern songs were considered effective instruments to strengthen the formation of collective identities. However, in a culturally fragmented region such as the Netherlands around 1800, these were hard to define. Especially in turbulent times, songs were are [sic] a unique medium to voice and spread ideas of community. Not only because the unique combination of text and music could empower such ideas, but also because collective singing practices could lead to an embodiment of the imagined communities evoked in the songs. How songs could channel ideas of community for political mobilization is demonstrated in a discussion of the marching song Marsch voor de Burger-Compagnie de Zwarte Knegten (1784, Bellamy & Nieuwenhuysen).
Enhancing the heritage conservation by Sustaining Historical Buildings: Hail Palace, as a case study
Authors: Alorf Abdullah , Al-Ansi Nashwan
Published: March 2021

Saudi Arabia has a wealth of heritage buildings that still exist today. Therefore, the need to preserve the architectural heritage of historical and cultural significance is becoming increasingly relevant. In line with the Saudi vision 2030.Thispaper aims to discuss the current situation of the king Abdul-Aziz palace in Hail, to enhance heritage conservation by sustaining historical buildings. Thus, efforts are continuing to evaluate the conservation to arrive at appropriate strategies. Therefore, the case study was chosen to explain the importance of the existing conservation policies to ensure that the heritage buildings are handled to retain their ingenuity.
Keywords: Heritage Conservation, Historic Buildings, Architectural Heritage, Preservation.
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bsby e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, UniversitiTeknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i16.2716
‘Working from Home’ – Recent development trends in terraced housing design in a new suburban township in Malaysia
Authors: Kholid Mohd Fairus , Zaharin Puteri Mayang Bahjah , Kasmuri Kartini , Zahari Yasin Ramadhan
Published: March 2021

The COVID-19 outbreak has caused a massive increase in the number of Malaysians working from home. This scenario has put the living and working gap at disposal, questioning the relevance of the ‘living lifestyle’, particularly in new housing township projects. This paper investigates the culture of working from home (WFH) and its influence on the spatial design of developer-designed terraced housing scheme for a new Suburban Township in Malaysia. Using qualitative observation and comparative analysis between developer’s home buying guide and the show unit, the findings suggest that ‘flexible open volume’ plan created through nooks and openings are the speculative future in promoting working from home. Hence, it advocates developers towards a double-frontage housing township that allows integration of living-working lifestyle as everyone works where they live and not vice-versa.   
Keywords: Working from home; Mindfulness; Spatial innovation; Housing development trend
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i16.2728
Small and Medium Tourism Enterprises Green Operation Performance Level
Authors: Yusof1 Zeenat Begam , Ibrahim Mansor , Jamaludin Mariam , Rashid Md Mizanur
Published: March 2021

Small and Medium Tourism Enterprises (SMTEs) contribute up to 70% of world pollution by consuming water, energy and producing solid waste. A similar scenario could be observed in the case of the Malaysian islands. Therefore, it is significant to understand SMITEs green operation performance level. Thus, this research aims to investigate into SMTEs green operation performance levels in the area of energy, freshwater, and solid waste. This research uses quantitative and qualitative methods for data collection. The findings indicate that the SMITEs have low performance in the area of freshwater and have moderate performance in energy and solid waste.
Keywords: Green practices; Performance level; Marine Park Islands; SMTEs
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i16.2729
Transitioning to Web-Based Learning in Basic Life Support Training During the COVID-19 Pandemic to Battle the Fear of Out-of-Hospital Cardiac Arrest: Presentation of Novel Methods
Authors: Naylor Katarzyna , Torres Kamil
Published: March 2021

Ongoing training in the area of basic life support aims to encourage and sustain the willingness to act in out-of-hospital cardiac arrest situations among first aiders. The contribution of witnesses and first aiders has diminished rapidly, as suspicion associated with the COVID-19 pandemic has risen. In this paper, we present teaching methods from the medical education field to create a new teaching-learning process for sustaining the prehospital involvement of first aiders and encourage new first aiders. The most important benefit—improving outcomes—can be achieved by introducing a variety of teaching-learning methods and formative assessments that provide participants with immediate feedback to help them move forward in the basic life support course. The new reality of web-based learning that has been introduced by the pandemic requires an innovative approach to traditional training that involves techniques and methods that have been proven to be useful in other fields.
Prognostic Prediction of Postoperative Non-Small Cell Lung Cancer Patients: An Ensemble Learning with Active Sampling Approach (Preprint)
Authors: Hu Danqing , Li Shaolei , Duan Huilong , Wu Nan , Lu Xudong
Published: March 2021

BACKGROUND

Lung cancer is the leading cause of cancer death worldwide. Prognostic prediction plays a vital role in the decision-making process for postoperative non-small cell lung cancer (NSCLC) patients. However, the high imbalance ratio of prognostic data limits the development of effective prognostic prediction models.

OBJECTIVE

In this study, we present a novel approach, namely ensemble learning with active sampling (ELAS), to tackle the imbalanced data problem in NSCLC prognostic prediction.

METHODS

ELAS first applies an active sampling mechanism to query the most informative samples for the current base classifier and then exploits those samples to update this base classifier to give it a new perspective. This training process is repeated until no enough samples are queried. Next, an internal development set is employed to evaluate the base classifiers, and the ones with the best performances are integrated as the ensemble model. Besides, we set up multiple initial training sets and internal development sets to ensure the stability and generalization of the model.

RESULTS

We verify the effectiveness of the ELAS on a real clinical dataset containing 1,848 postoperative NSCLC patients. Experimental results show that the ELAS achieves an averaged 0.732 AUC value for all 6 prognostic tasks and obtains 2.3%, 1.4%, 1.3%, 1.5%, 4.4% improvements over the SVM, AdaBoost, Bagging, SMOTE and TomekLinks, respectively.

CONCLUSIONS

We conclude that the ELAS can effectively alleviate the imbalanced data problem in NSCLC prognostic prediction and demonstrates good potential for future postoperative NSCLC prognostic prediction.
Framtidens kvinnor. Mognad och medborgarskap i svenska flickböcker 1832–1921
Authors: Andersson Maria
Published: March 2021

The future woman – what would she be like? And what would be her place in society? These questions were explored through stories about girls’ upbringing and education in nineteenth and early twentieth century literature for girls. About the time of the breakthrough of women novelists in the 1830s, books for girls started to be published. They depict everyday games and exhilarating adventures, student life and vocational dreams. By addressing girls directly, these books aimed at both discussing and influencing future female citizens. In Future Women, Maria Andersson shows how Swedish literature for girls and its depiction of young women was a part of the nineteenth century debate on women’s civil and political rights. The genre gathered authors of different political convictions but they were all united by the fact that young women became the focal point of contemporary social changes in their works. Housewifely girls, manly women students and shopping coquettes illustrated different paths to adulthood and modern life. In the girl book genre, the young woman was simultaneously a vehicle of nostalgic memories from a lost world and the promise of a more equal, peaceful future.
Stilometrijska analiza slovenske pripovjedne književnosti do prve izvorne slovenske priče
Authors: Žejn Andrejka
Published: March 2021

STYLOMETRIC ANALYSIS OF SLOVENIAN NARRATIVE LITERATURE UP TO THE FIRST ORIGINAL SLOVENIAN NARRATIVE

Quantitative approaches in studying literature already have a long tradition, reac-hing back to the period before digital humanities became an established field in the humanities. An important impetus for the establishment of quantitative methods in the humanities was provided by increasing computer power and increasingly extensive corpuses of machine-readable words. Theoretical concepts refer to the new methodological paradigms as distant reading. Even though it is supposed to replace close reading, it has repeatedly been shown that traditional research forms the necessary basis for relevant quantitative research and new relevant findings. Stylometry, or quantitative analysis of style, applies statistical methods to literary texts. The analysis entails text comparison in terms of similarities and differences in measurable text characteristics, such as the most frequent words. This is a well-pro-ven method, which, however, has certain limitations. Stylometry is a text-immanent method that does not provide absolutely valid answers or general findings about style. In addition, the definition of measurable characteristics and the comparison method used remain in the domain of the researchers and their familiarity with the material. However, it allows a simultaneous overview of a large collection of texts and hence reaches beyond the established canon incorporating trivial literature and translated literature as an important segment of national literature, especially in its early periods. Stylometric analysis identifies text patterns, which can either be confirmed by qualitative research or can indicate the necessity for a new approach to traditional research. The visualization of results of the stylometric analysis of Slovenian narrative literature from the first half of the seventeenth century to the first original Slovenian narrative in 1836 shows the development of Slovenian narra-tive literature by period, with identifiable hallmarks of certain authors, and within individual periods and genres. Certain links indicate a need for further research.
CAUSALITY MODEL OF CONSUMER PURCHASE INTENTION ON ENVIRONMENTALLY FRIENDLY PACKAGING BEVERAGE PRODUCTS
Authors: Mahmud Muhammad Zulfiqar , Widayat Widayat , Wijaya Rahmad
Published: March 2021

This study aims to construct a correlational model for the determinant of consumer purchase intention on environmentally friendly packaging beverage products by examining the product image and company reputation as mediators in the association of green perceived value on consumer purchase intention with the ex-post facto quantitative approach. The target population is the community in Malang City, EastJava who is aware of the existence of cardboard packaging beverage products and intends to purchase the products. Data were collected by employing a questionnaire distributed online. 300 respondents were selected by convenience sampling. The collected data were analyzed using Structural Equation Modeling (SEM) by utilizing AMOS software. The final model was obtained with an adequate Goodness of Fit value.The structural model that has been successfully constructed shows that green perceived value has no significant effect on purchase intention. Besides, the product image and company reputation play a role in mediating the impact of Green Perceived Value on Purchase Intention.
Duplex ultrasound of vascular access for hemodialysis thrombosis
Authors: Koen V. S. , Zahmatova T. V. , Holin A. V.
Published: March 2021

Introduction. The most common complication of the vascular access for hemodialysis, that can lead to its loss, is thrombosis. The method of choice in diagnosing fistula thrombosis is duplex ultrasound. Purpose: to study the ultrasound signs and changes in hemodynamics data in thrombosed fistulas and to determine the risk factors contributing to its development. Materials and methods. Duplex ultrasound was performed in 550 patients with vascular access for hemodialysis. Access thrombosis was detected in 12,0%, non-occlusive thrombosis was observed in 60,6%, occlusive thrombosis — in 39,4%. Thrombosis was significantly more common in women than in men (p=0,025). In patients with graft, thrombosis was more common (24,2%) than in those with arteriovenous fistula (11,2%), p=0,026. A correlation was found between the presence of significant vascular access stenosis, aneurysm of the outflow vein or graft, and the development of thrombosis (p<0,02). Duplex ultrasound allows to diagnose vascular access thrombosis and to determine the causes of its development.
Inulinase Production by Filamentous Fungi Indigenous to Saudi Arabian Soils
Authors: Shuroq Mohsin Al-
Published: March 2021

represents a source for the production of oligosaccharides by enzymatic hydrolysis (inulinase enzyme) that is used widely in industrial and medical applications. This research aims to identify the filamentous fungi indigenous and occupant and grow the filamentous fungi, then assess the thermotolerant inulin-degrading fungal isolates and investigate the higher yield produced by local fungal stains of inulinase enzyme, and comparing with reference ones, as well as Identify the growth parameters conditions that affecting on enzyme production local fungal strains. Fourteen agricultural soil samples were collected from the top layer (0-15 cm) from different regions of the territory of the Kingdom of Saudi Arabia (by placing 100 g of the soil sample from each region), depending on the climatic differences. Soil sample sites were Mecca, Al- Riyadh, AlQassim, AlBaha, AlGouf. The fungi produced inulinase enzymes are isolated and incubated at 28-30°C for 10 days, then DNA was isolated and tested for thermo-tolerance. In addition to this, the inulinase enzyme in liquid media (time course) was assessed and the optimum production conditions were studied (Agitation, temperature, pH, the concentration of inulin, carbon sources, nitrogen source). There are thirty fungal isolates from twelve soil samples, they belong to Aspergillus, Fusarium, Penicillium, Trichoderma, Rhizoctonia, Mucor, Alternaria, and Rhizopus genus. The inulinase enzyme activity ranged between 11.76-39.16 U/ml, as well as the optimum production conditions, are: agitation at 150 rpm, incubation temperature at 30°C, pH 6, 2% of inulin concentration, maltose as carbon source, and tryptone as a nitrogen source. Finally, high inulinase productivity was obtained by local fungal strain in this study.
TAX SHELTER TERRORS: THE REAL STORY OF CANADIAN CULT CINEMA
Authors: Xavier Mendik
Published: March 2021

This 2016 UK/Canadian documentary is the first practice as research project to fully explore the social and historical significance of the controversial ‘tax shelter’ films that were released in Canada between 1974 and 1984. It considers both the tax shelter phenomenon (which allowed investors to deduct 100% of taxable investment in film production), and the dramatic expansion in populist Canadian cinema it prompted (including ‘body horror’ films, home invasion thrillers, ribald teen movies and regional sex comedies).
Intravenous injection of mesenchymal stem cell spheroids for efficient pulmonary delivery and prolonged in vivo survival
Authors: Shimazawa Yoshihiko , Kusamori Kosuke , Tsujimura Mari , Shimizu Kazunori , Konishi Satoshi , Nishikawa Makiya
Published: March 2021

Because of their excellent therapeutic potential, mesenchymal stem cells
(MSCs) have been used as cell therapeutics for various diseases.
However, the survival rate and duration of MSCs after transplantation
are extremely low and short, respectively. To solve these problems, in
this study, we prepared multicellular spheroids of MSCs and investigated
their survival and function after intravenous injection in mice. The
murine adipose-derived MSC line m17.ASC was cultured in agarose-based
microwell plates to obtain size-controlled m17.ASC spheroids of an
average diameter and cell number of approximately 170 μm and 1100
cells/spheroid, respectively. The intravenously injected m17.ASC
spheroids mainly accumulated in the lung and showed a higher survival
rate than suspended m17.ASC cells during the experimental period of 7
days. m17.ASC spheroids efficiently reduced the
lipopolysaccharide-induced increase in plasma concentrations of
interleukin-6 and tumor necrosis factor-α. These results indicate that
spheroid formation improved the pulmonary delivery and survival of MSCs,
as well as their therapeutic potential against inflammatory pulmonary
diseases.
Smart Check - COVID-19 triage system: evaluation of the impact on the screening time and identification of clinical manifestations of SARS-CoV-2 infection in a public health service.
Authors: Anschau Fernando , Worm Paulo , Kopittke Luciane , Villwock Luis Humberto de Mello , Sartori Marcos Luiggi Lemos , Pinheiro Sandro , Rosário Jéferson Cardoso do , Inácio José Francisco Secorun , Much Maicon Diogo , Marckmann Eduardo , Vissoci João Ricardo Nickenig , Machado Wagner de Lara , Costa Dalton Breno , Klug Daniel , Prestes Juliane Martin , Hessel Fabiano
Published: March 2021

Introduction: Most patients with COVID-19 have mild or moderate
manifestations, however, there is a wide spectrum of clinical
presentations and even more severe repercussions that require high
diagnostic suspicion. Vital sign acquisition and monitoring are crucial
for detecting and responding to patients with COVID-19. Objective: Thus,
we conducted this study to demonstrate the impact of using a tool called
Smart Check on the triage time of patients with suspected COVID-19 and
to identify the main initial clinical manifestations in these cases.
Methodology: We assessed triage times before and after the use of Smart
Check in 11,466 patients. In this group, we identified 211 patients for
the identification of COVID-19 clinical manifestations in a case-control
analysis. Results: Smart Check was able to decrease the triage time by
33 seconds on average, with 75% of the exams being performed within 5
minutes, whereas with the usual protocol these steps were performed
within 6 minutes. A range of clinical presentations made up the COVID-19
initial manifestations. Those with the highest frequency were dry cough
(46.8%), fever (41.3%), dyspnea (35.8%), and headache (32.1%). Loss
of appetite, fever, and ageusia were the manifestations that had a
statistically significant association with the SARS-CoV-2 presence.
Conclusions: Smart Check, a simple clinical evaluation tool, along with
the targeted use of rapid PCR testing, can optimize triage time for
patients with and without COVID-19. In triage centers, a number of
initial signs and symptoms should be cause for SARS-CoV-2 infection
suspicion, in particular the association of respiratory, neurological,
and gastrointestinal manifestations. Keywords: new coronavirus,
COVID-19, triage, clinical manifestations
Spatial and Temporal Variability of Rotational, Focal and Irregular Activity: Practical Implications for Mapping of Atrial Fibrillation
Authors: Pope Michael , Kuklik Pawel , Gala Andre Briosa e , Leo Milena , Mahmoudi Michael , Paisey John , Betts Tim
Published: March 2021

Background Charge density mapping of atrial fibrillation (AF) reveals
dynamic patterns of localised rotational activation (LRA), irregular
activation (LIA) and focal firing (FF). Their spatial stability,
conduction characteristics and the optimal duration of mapping required
to reveal these phenomena and has not been explored. Methods Bi-atrial
mapping of AF propagation was undertaken and variability of activation
patterns quantified up to a duration of 30-seconds(s). The frequency of
each pattern was quantified at each vertex of the chamber over 2
separate 30s recordings prior to ablation and R2 calculated to quantify
spatial stability. Regions with the highest frequency were identified at
increasing time durations and compared to the result over 30s using
Cohen’s kappa. Properties of regions with the most stable patterns were
assessed during sinus rhythm and extrastimulus pacing. Results In
twenty-one patients, 62 paired LA and RA maps were obtained. LIA was
highly spatially stable with R2 between maps of 0.83(0.71-0.88) compared
to 0.39(0.24-0.57) and 0.64(0.54-0.73) for LRA and FF, respectively. LIA
was also most temporally stable with a kappa of >0.8
reached by 12s. LRA showed greatest variability with
kappa>0.8 only after 22s. Regions of LIA were of normal
voltage amplitude (1.09mv) but showed increased conduction heterogeneity
during extrastimulus pacing (p=0.0480). Conclusion Irregular activation
patterns characterised by changing wavefront direction are temporally
and spatially stable in contrast with rotational patterns that are
transient with least spatial stability. Focal activation appears of
intermediate stability. Regions of LIA show increased heterogeneity
following extrastimulus pacing and may represent fixed anatomical
substrate.
UNRESECTABLE HEPATOBLASTOMA, LIVING DONATION AND PRE-TRANSPLANT FACTORS ASSOCIATED WITH EVENT-FREE SURVIVAL
Authors: Seda-Neto Joao , Feier Flávia , Pugliese Renata , Candido Helry , Vincenzi Rodrigo , Porta Gilda , Miura Irene , Baggio Vera , Porta Adriana , Rodrigues Celso , Costa Cecilia da , Melaragno Renato , Epelman Sidnei , Winneschhofer Ana Paula , Fonseca Eduardo , Chapchap Paulo
Published: March 2021

Background: Hepatoblastoma (HB) treatment has improved over time with
established chemotherapy (Qtx) protocols, and liver resection or liver
transplantation (LT). However, the right timing for LT and adequate
patient selection are key to achieve acceptable disease-free survival
rates in patients with unresectable HB. Few groups have reported such
factors in the setting of living donor liver transplantation (LDLT).
Procedure: This single-center retrospective analysis of 28 children with
HB submitted to LDLT aimed at determining the pre-transplant factors
associated with worse post-transplant event-free survival. Results:
Patients were divided in groups according to the occurrence of the event
(recurrence/death) after LDLT – 10 patients in the event-yes and 18
patients in the event-no. Probability of 5-y event-free survival was
63.9%. Alpha-fetoprotein (AFP) reduction post-Qtx > 70%
had a good performance for the occurrence of the event, with a
calculated AUC of 0.8. A scoring system was derived from the
pre-transplant risk factors (AFP reduction < 70%, time from
diagnosis to LDLT > 12 months, rescue LT) for the
probability of the event: no risk factor present (15.4%), one risk
factor present (33.3%), and > 2 risk factors present
(66.7%), (p=0.02). Conclusion: LDLT for HB is the preferred treatment
option for unresectable HB, with no distant metastasis and adequate
response to Qtx. The pre-transplant factors composing the risk score
should be critically evaluated in order to move forward with the LDLT.
However, due to the limited number of patients in this study, a larger
number of patients is required to corroborate these findings.
The data we have: Pregnancy and birth related data collection in Australia, Canada, Europe and the USA- A web-based survey of practice
Authors: Lamont Kathleen , Scott NW , Bhattacharya S
Published: March 2021

ObjectiveTo determine the feasibility of combining routinely recorded perinatal data from several databases in high-income countries to assess the risk of recurrent stillbirth.
MethodsWeb-based questionnaire survey with reminder emails and searching of relevant country websites.
Results120 countries/regions in Canada, Europe and the USA were invited to participate and 83 (69%) responded. Of those one had no data, and two did not wish to take part. The remaining 80 were sent the questionnaire and 63 (53%) were completed. Twenty-seven countries/regions reported that they collect information on all perinatal events (including early pregnancy loss), 34 on live births and stillbirths and two only live births (stillbirths recorded in a separate database). Most countries (53/63) can link two or more pregnancies occurring in the same woman. Data and information extracted from the Australian and New Zealand Government websites showed that information on all perinatal events is collected nationally in New Zealand and in 5/8 regions in Australia. Both Australia and New Zealand can link two or more pregnancies occurring in the same woman. Maternal age and caffeine consumption were the most and least consistently collected demographic indicators respectively. Diabetes mellitus and mental health problems, birthweight and obstetric cholestasis the most and least consistently collected for medical conditions and pregnancy condition/complications. Procedures for gaining access to data vary between countries.
ConclusionThis study demonstrates that it is possible to link pregnancies in the same woman to assess the risk of recurrent stillbirth using routinely collected perinatal data in all states/territories in Australia, 7/8 responding provinces/territories in Canada, 21/27 responding countries/regions in Europe, New Zealand and 26/28 responding states in the USA. The scope of the databases and quality and extent of data collected (thus their potential use) varied, as did procedures for accessing their data.
THE ANTI HRSV ACTIVITY OF Ferula halophila Peşmen AQUEOUS AND METHANOL EXTRACT BY MTT ASSAY
Authors: DOĞAN Hasan Hüseyin , DUMAN Rüstem
Published: March 2021

The trend towards natural products in the world is increasing due to the increased drug resistance of infectious diseases, the high prices for drugs and the difficulty of access. Also, bacterial or viral diseases that are difficult to treat and need a long time for proper treatment cause important infections in people. Since effective drugs could not be developed for most viral infections, it is very important to find natural products against viruses to introduce them to the world of science. The antiviral activities of the aqueous and methanol extract from Ferula halophila Peşmen, an endemic species to Turkey, has been investigated against human respiratory syncytial virus (HRSV, ATCC-VR-26). The cytotoxic and antiviral properties of plant extracts were investigated in HRSV / HEp-2 cell systems, respectively by the colorimetric MTT assay. In the study, the titer of RSV was used as 100 TCID50 (50% tissue culture infective dose). While MNTC (Maximum non-toxic concentration) of methanol extract was 195.313 µg/mL and CC50 (50% cytotoxic concentration) was 4366.22 µg/mL, it was determined as MNTC = 390.625 µg/mL and CC50 = 4366.22 for aqueous extract. According to the results, methanol extract showed more toxicity than the aqueous extract. The MNTC of Ribavirin used as a positive control was determined as 0.98 µg/mL and CC50 was 110.40 µg/mL.As a result of the study, it was determined that the methanol extract was not effective, whereas the aqueous extract had a significant anti-HRSV activity with the values of 50.69 µg/mL EC50 (50% Effective Concentration) and 97.54 Selectivity Index (SI). The EC50 and SI values of Ribavirin were 2.39 µg/mL and 46.19, respectively.According to the results, we can explain the presence of antiviral activity only in the aqueous extract and the absence in the methanol extract by the high toxicity of it and the insolubility of the antiviral compounds in the methanol extract.
From present to future. An academic perspective of Public Archaeology in Spain
Authors: Castillo Mena Alicia
Published: March 2021

Ten years seems little time to assess the future of such a relatively young topic as Public Archaeology (PA) is, in special in Spain and in the academic arena. I divide my answer in two classic parts: present and future. By understanding the present (based on the past) we can try to guess (more or less) the future… Even if we think in the context of a pandemic, predicting the future of anything becomes really uncertain and reckless. If I may write, there is a high level of uncertainty and luck in getting it right.
Toward a Decolonial and Denationalized Public Archaeology
Authors: Greenberg Rafael
Published: March 2021

It has been more than a decade since I completed my own participation in a public archaeology project at Rogem Gannim, in West Jerusalem (Natasha Dudinski, “The Past on our Doorstep,” https://www.youtube.com/watch?v=ef3fPcrB11c); since then, in the role  of an archaeological activist and advocate, I have observed the progress of public archaeology in Israel and abroad and participated in the local and global dialogue (Clark and Horning 2019), without initiating new fieldwork. This brief note, though looking toward the future as requested by the editors, is therefore retrospective in origin, rather than being a missive from the front lines.
IMPLEMENTASI PENDIDIKAN KARAKTER DALAM PEMBELAJARAN BAHASA INDONESIA DI SMP AL-IRSYAD SURAKARTA
Authors: Revita Feri , Dewa Metha , Anjani Listy , Fatoni Muhad
Published: March 2021

Tujuan Penelitian ini adalah mengetahui proses implementasi pendidikan karakter dalam membentuk sikap dan perilaku sosial peserta didik melalui pembelajaran bahasa indonesia di SMP AL-IRSYAD Surakarta, mengetahui sikap dan perilaku sosial peserta didik saat pembelajaran sejarah di SMP AL-IRSYAD Surakarta, dan mengetahui kendala apa saja yang di alami guru bahasa Indonesia dalam implementasi pendidikan karakter dalam membentuk sikap dan perilaku sosial peserta didik di SMP AL-IRSYAD Surakarta. Penelitian ini adalah penelitian kualitatif fe- nomenologis. Sasaran penelitian ini adalah guru bahasa indonesia dan siswa kelas VII di SMP AL-IRSYAD Surakarta. Teknik pengumpulan data menggunakan teknik Observasi, dokumentasi dan wawancara. Uji validitas data dengan triangulasi sumber. Teknik analisis data menggunakan reduksi data, display, penarikan kesimpulan dan verifikasi. Hasil penelitian ini adalah proses implementasi pendidikan karakter dalam membentuk sikap dan perilaku sosial siswa di lakukan di luar kelas berkaitan dengan peraturan sekolah yang menjadi kebiasaan dan di dalam kelas di sesuaikan dengan materi yang berhubungan dengan nilai-nilai karakter yang nantinya dapat membentuk sikap dan perilaku sosial siswa. Sikap dan perilaku sosial siswa SMP AL-IRSYAD Surakarta dapat dikatakan sudah baik. Kendala yang di alami guru bahasa indonesia adalah peraturan pemerintah yang berubah-ubah serta karakteristik siswa yang berbeda-beda.
O impacto da institucionalização da governança de Tecnologia da Informação no desempenho da governança de TI e o papel do Job Crafting
Authors: Mezzomo Luciano Edimara , Mendes Fantinel Leonardo , Mendes Lübeck Rafael
Published: March 2021

A presente pesquisa quantitativa analisou a relação entre Job Crafting, institucionalização da Governança de TI e o desempenho da Governança de TI. A variável Job Crafting é uma forma específica de comportamento proativo que demonstra o quanto os funcionários estão engajados para melhorar seu desempenho no trabalho. A variável Institucionalização de governança de TI refere-se a institucionalização regulatória, normativa e cultural-cognitiva da governança de TI. A pesquisa foi realizada em uma instituição financeira cooperativa com atuação no Brasil que foi respondida por 134 colaboradores da área de TI. Para analisar os resultados foi utilizada a técnica dos Mínimos Quadrados Parciais. Como resultado este estudo permitiu identificar como Job Crafting e institucionalização da governça de TI impactam o desempenho da governança de TI.
O Oblíquo e o Elíptico: um à propos acerca de uma ou mais fotos de Marc Trivier
Authors: Cavargere Claudio
Published: March 2021

O presente artigo tem como objetivo traçar linhas de confluência entre a linguagem e a imagem à luz das contribuições de Michel Foucault. Longe de enunciá-las de maneira passiva, fazendo-as brilhar, o que se buscou foi dirigi-las como flechas contra seu próprio criador, para, talvez, mais do que iluminar, fazer explodir.
Vagabundagem sonhadora e imagem de si
Authors: Peres Pissarra Maria Constança
Published: March 2021

O objetivo deste texto é analisar nas Rêveries d’un promeneur solitaire, mais precisamente no primeiro e no oitavo devaneio, a decisão de Jean-Jacques Rousseau pelo rompimento com a humanidade
A GESTÃO ESCOLAR E O OLHAR PEDAGÓGICO NO COTIDIANO DA ESCOLA: UMA EXPERIÊNCIA DE SUPERAÇÃO DA NÃO APRENDIZAGEM DA LEITURA E DA ESCRITA
Authors: Pretto de Oliveira Rosane Alves
Published: March 2021

O presente artigo descreve as ações conjuntas entre professoras e gestora escolar para possibilitar que estudantes superassem a não aprendizagem da leitura e da escrita. Face ao índice de reprovação, divulgado em 2018 no município, demonstrando que cerca de 300 alunos reprovaram no 3º ano do Ensino Fundamental, surge a preocupação nas escolas em melhorar esse resultado. Nesse cenário, apresenta-se a experiência de uma escola municipal, descrevendo os procedimentos adotados para auxiliar nessa aprendizagem. A partir de grupos de discussão, debatiam-se alternativas e ações a serem implementadas para preencher lacunas na alfabetização de 13 crianças, de dois 3ºanos do Ensino Fundamental que, ao final do primeiro trimestre de 2019, apresentavam-se, ainda, não alfabetizados. No projeto, professoras e gestora escolar acompanharam de perto o processo pedagógico, planejando e desenvolvendo estratégias que possibilitaram a aprendizagem das crianças; promoveram reflexões e mudança acerca da metodologia utilizada para alfabetizar na escola e a prática colaborativa.
Отходы жизнедеятельности палочника аннамского как удобрение
Authors: Некрасов Елизар , Саранчина Наталья
Published: March 2021

Работа посвящена изучению экскрементов палочника аннамского в качестве возможного удобрения для домашних растений. Исследовалось их влияние на прорастание и первые этапы развития разных видов растений. Грунт с экскрементами палочников был проанализирован на состав по азоту, фосфору и калию.
導言
Authors: DU Zhizheng
Published: March 2021

LANGUAGE NOTE | Document text in Chinese知情同意是現代生命倫理學最重要的概念之一，也是現代生命倫理學所以充滿活力和備受世人囑目的重要原因。知情同意這一概念雖然已經歷100 多年的歷史，但在《紐倫堡法典》誕生以前，知情同意往往只是作為醫生爭取病人的配合和支持，以提高治療效果，或者為防範醫療糾紛而採取的一種手段。只是在《紐倫堡法典》問世後，特別是伴隨著聯合國的《世界人權宣言》發表後50 多年的人權運動蓬勃發展，知情同意獲得了新的意義，它首先被理解為對人的生命權和健康權的尊重，對人的權利的尊重。的確，人的生命和健康首先是屬於自己的，因而對生命和健康的任何干預，當然理應得到本人的同意，儘管這種干預有益於生命和健康的維護。特別是在當代醫學對人體生命和健康干預的力度越來越大，後果越來越嚴重，影響越來越深遠的情況下，人們怎能不關心醫學可以給本人帶來的後果呢？怎能不把對本人生命和健康的處置權利掌握在自己的手中呢？正因為如此，知情同意在全世界不同地域、不間民族和不同文化背景的國家，都得到了廣泛的認同，並體現在許多國家醫事和科學研究的法律檔中，體現在廣大醫務人員的行動中。但是，人們對知情同意的理解和認識，由於各自的文化背景和國家體制的差異，卻存在眾多的不同；同時，由於各自國家的醫療習慣和傳統的不同，在實踐知情同意原則時也遇到了各種各樣的問題。為了推動對這一問題的研究，本刊這一期就此發表了一組文章，從不同角度就知情同意原則做了分析，我們希望引起對知情同意的進一步討論和研究。DOWNLOAD HISTORY | This article has been downloaded 11 times in Digital Commons before migrating into this platform.