bluuebunny/crossref_metadata_2025 huggingface dataset:
“Integrative Health System” beyond “Integrative Medicine”
Authors: Priya Ritu
Published: September 2023

One Nation, One Health System has many dimensions, and an inclusive Integrative Health System is one of the overarching and cross-cutting approaches to attain it. This paper discusses the imperatives for creating an Integrative Health System that incorporates AYUSH and Allopathic knowledge traditions. Since Integrative Health System is a term diversely understood and used, the need to conceptualize it and come to a shared understanding is highlighted. The paper brings insights and tools from a Health Systems perspective to suggest conceptualizing an Integrative Health System framework. It proposes that the IHS has three components— Integrative Medicine, Integrative Public Health, and an Integrative Health Care System. After discussing these components, the paper moves on to the Health Systems Research required for designing an Integrative Health Care System. The Complex Adaptive Systems approach is considered appropriate and explained. An illustration is provided from a study conducted to study the role and status of Ayush services and Local Health Traditions in the Public health system. Inferring conclusions from the study mentioned above and similar studies undertaken by the author, few illustrative inputs regarding Integrative Health Systems are provided, which would adequately support an ecosystem that allows interaction and dialogue between systems. It is postulated that this requires a shift in thinking from the dominant positivist paradigm to a critical holist paradigm.
One Nation, One Health System integrative policy
Authors: Katiyar Chandrakant , Dubey Sunil K.
Published: September 2023

Convergence of Ayush/traditional medicines with modern medicines by bringing into effect integration of the two or more systems is the way forward for developing holistic healthcare systems throughout the country, based on the concept of the One Nation, One Health System. Adopting schemes, programs, and strategies for bringing about changes in the education system and medical practice, along with ensuring their implementation at each stratum, will aid in unifying the healthcare systems. Given the existence of medical pluralism in India, it is the need of the hour to amalgamate our ancient traditional knowledge and contemporary medicine to build a system wherein both work in unison to promote good health and confer protection from various diseases and make provision for their management in the best possible manner. The current article discusses the requirements and probable impact of developing such system.
An open-label prospective interventional study to assess the prophylactic effect of Guduchi Ghan Vati in COVID-19
Authors: Vyas Kavita , Chandla Anubha , Nariyal Vikas , Yadav Babita , Amin Hetalben D. , Khanduri Shruti , Sharma Bhagwan Sahai , Rana Rakesh Kumar , Singhal Richa , Tripathi Arunabh , Chandrasekhararao Bhogavalli , Srikanth Narayanam , Dhiman Kartar Singh
Published: September 2023

BACKGROUND:

Several studies have proven the immunomodulatory action of Guduchi (Tinospora cordifolia). Immunomodulation strategy is a crucial requirement to control coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus 2. Therefore, Guduchi Ghan Vati (GGV), tablets prepared from water extract of T. cordifolia, is selected to prevent COVID-19.

OBJECTIVE:

This study aimed to know the prophylactic effect of Ayurvedic intervention, that is GGV, in preventing COVID-19 infection among the community of containment areas.

MATERIALS AND METHODS:

It was an open-label, prospective, nonrandomized, community-based interventional study carried out from May 6 to June 23, 2020, in a containment zone (Bijhari) of District Hamirpur, Himachal Pradesh, India. GGV was given to the community in the dose of 500 mg twice a day with lukewarm water on an empty stomach for 30 days. The demographic and health-related data of the participants were collected using Google forms, and follow-up was done on the 30th day through telephonic interviews.

RESULTS:

A total of 1165 participants’ data were analyzed to assess the prophylactic effect of GGV. In the sample, 85.2% of participants had no systemic disorders, whereas 13.8% took concomitant medicines for other morbidities. The incidence of COVID-19-positive cases was only 0.1% (n = 01).

CONCLUSION:

Ayurvedic intervention GGV was found to have prophylactic potential against COVID-19 infection.
Integrative medicine
Authors: Kumar Abhimanyu
Published: September 2023

In India, various healthcare systems are practiced, and every system is well-received by its citizens. Recently, the Government of India has planned to develop a “One Nation, One Health System” to offer a unified Health Care System with all the possible advantages of every system of medicine. Regarding such a plan, a well-designed Integrative Medicine Protocol for various diseases is the need of the hour. This approach to health care should be implemented after a thorough review of the situation, which may come across as a hurdle. A single healthcare system will allow for better outcomes and potentially improve the country’s quality of health care.
Login of CCRAS Ayur Prakriti web portal
Authors: Vijaivargia Shilpa , Lavaniya Vinod Kumar , Narayanan Rakesh
Published: September 2023

Information Technology drives this digital era (IT) enabled services. IT has evolved rapidly with the integrated use of electronic communication, computers, the internet of things (IoTs), and other allied devices in almost every domain. IT software and hardware tools are considered the backbone of research as they produce results from data samples quickly, efficiently, and reliably. Integrated calculations from multitier data samples require customized IT tools per the research requirements and the standard IT tools available in the market. Organizations hire IT services and human resources to design, develop and implement such tools. The Prakriti Assessment Scale developed by the Central Council for Research in Ayurvedic Sciences (CCRAS), Ministry of Ayush, Government of India, is a scale to assess the Prakriti (somatic constitution) of an individual. Based on the requirement of Prakriti assessment at multiple locations simultaneously and compilation of results for analysis, an integrated web-based solution- Ayur Prakriti Web Portal has been developed by CCRAS, which is the digital conversion of the Prakriti Assessment Scale. Currently, the Ayur Prakriti portal is in the Beta testing phase. This article will provide a technical review of the features and parameters defined in the CCRAS - Ayur Prakriti web portal login page from an IT perspective. It will also provide a comparative analysis of business processes followed in the Prakriti Assessment software viz-a-viz standard business processes to be followed in application software as per the software design guidelines/standards. The objective of this article is to carry out a situational analysis focusing on design steps taken for developing the Ayur-Prakriti Web Portal.
Efficacy and safety evaluation of Shatavari Gudam and Triphala Kashaya in leucorrhoea (Shwetapradara) – A study protocol of an open-label, multicenter, interventional, single-arm trial
Authors: Gopod Savita Poshatti , Dhoke Sujata , Anumol K. , Kumar Pradeep , Sheji Soumya , Talekar Manisha , Sharma Lalita , Tripathi Arunabh , Ota Sarada
Published: September 2023

BACKGROUND:

In the classical text of Ayurveda, formulations Shatavari Gudam (SG) and Triphala Kashaya (TK) are indicated to treat Shwetapradara. The disease Shwetapradara can be correlated to leucorrhoea based on the similar symptom, painless, white-colored discharge from the vagina. SG is a formulation containing Shatavari (Asparagus racemosus) as a main ingredient. Several studies indicate Shatavari as a tonic for reproductive tract-related diseases. The external use of Triphala has anti-inflammatory, antiseptic, and anti-bacterial actions. The present article is a clinical study protocol on the efficacy and safety evaluation of SG and TK in leucorrhoea (Shwetapradara).

MATERIALS AND METHODS:

It will be a multicenter, prospective single-arm study planned to be conducted at Regional Ayurveda Research Institute, Thiruvananthapuram, Regional Ayurveda Research Institute Nagpur, National Ayurveda Research Institute for Panchakarma, Cheruturthy and Regional Ayurveda Research Institute Vijayawada. One hundred sixty participants will be recruited for the trial (40 from each center). In the dose of 6gm, SG will be administered twice daily with lukewarm water after food. Vaginal douche will be done with TK for seven days in two consecutive cycles. The primary outcome will be change in the quantity of white discharge using visual analog scale. The secondary outcome will be change in other associated symptoms like pruritis vulva, lower abdominal pain, low back ache, burning micturition, and dyspareunia using the Visual Analogue Scale; change in the Quality of life and well-being by PGWBI score; change in Score of Investigator’s Global Satisfaction Scale, and changes in Patient’s Global Satisfaction Scale from baseline to final visit. Clinical/biochemical assessments will determine the safety and tolerability of the formulation during the follow-ups. Compared with the baseline, the efficacy of interventions on the 84th and 98th day, will be assessed with Paired t-test. Data will be analyzed using SPSS 15.0 software.

ETHICS AND DISSEMINATION:

The IEC clearance has been obtained from each participating institute. After completion of the trial, the outcome will be disseminated through peer-reviewed journals for publication.
One Nation One Healthcare System
Authors: Patwardhan Bhushan , Singh Rajeshwari
Published: September 2023

The importance of the pluralistic healthcare approach and evidence-based integration of medical systems is well recognized in various reports and policies. There is a need to bring synergy in the context of public health, medical and health education, research, clinical practice, and health administration. There is a growing consensus in favor of transforming the pathy-centric fragmented healthcare system to a people-centric integrative healthcare system in a stepwise manner near future. One Health concept is more about zoonotic and environmental considerations. We propose a One Nation One Healthcare (ONOH) system concept that tries to build on the idea that One Health prioritizes people’s basic healthcare needs and brings the best from scientific experimental research and traditional experiential practices as consolidated evidence-based medicine. ONOH does not mean mixopathy or monopoly of any one system. Whether this is a utopian esoteric idea or an essential act in the best interest of people and nation for moving toward universal health coverage requires a serious dialog and action.
Ayurveda management of jaundice: A case study
Authors: Sinha Nitu , Ojha Nisha Kumari
Published: September 2023

Jaundice is a yellow discoloration of the body’s tissues from excess bilirubin (hyperbilirubinemia). According to the Ayurveda perspective, the clinical presentation of jaundice can be correlated with that of the disease Kamala. We present a case of a 10-year-old female patient who attained the outpatient department with complaints of anorexia, poor appetite, general weakness, abdominal pain, and hard stools since 10 days. The examination revealed yellow discoloration of the sclera, oral mucosa, skin, urine, and hard yellowish stool, and the blood investigation revealed elevated level of serum bilirubin, serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, and alkaline phosphatase. The case was managed with Tab Liv 52 DS, 1 tab twice a day and Tab Nirocil, 1 tab twice daily before food with lukewarm water. Mridu Virechana (mild purgation) was done using a combination of Avipatikar Churna 2 gm twice a day and Kutki Churna (powder of Picrorhiza kurrooa) 1 gm twice a day with lukewarm water for 4 weeks. These medications effectively improved the clinical symptoms, and the appetite increased, the patient became more active, and the icterus decreased. The patient also started passing normal stool and urine. complete blood count, liver function test , and urine examination revealed that the values were within the reference range. This combination can be utilized for symptoms of Koshthashrita Kamala.
Effectiveness of anal infiltration with Murivenna oil, internal administration of Triphala choorna, sitz bath, and fiber diet protocol in acute and chronic anal fissures
Authors: Kizhakke Meladam Pratap S. , Nair Pratibha P. , Sureshkumar Gayathri , Sudhakar Devarakonda
Published: September 2023

BACKGROUND:

Anal fissure (fissure in ano) is an excruciating manifestation among common anorectal presentations. The condition inflicts significant personal and social ill health causing considerable morbidity. This study aimed at documenting the effect of Murivenna oil infiltration and Triphala choorna oral use along with sitz bath and fiber diet protocol in the management of fistula in ano.

MATERIALS AND METHODS:

Retrospective analysis of 15 cases diagnosed with primary fissure in ano who underwent prescribed conservative Ayurvedic treatment between March 2018 and February 2019 at the National Ayurveda Research Institute for Panchakarma, Cheruthuruthy, is reported. All patients were managed with anal infiltration of Murivenna oil (30 ml), internal administration of Triphala choorna (10 g), sitz bath, and fiber diet. Retrospective outcome analysis of recorded change in each case on study variables, viz. pain, bleeding per rectum (BPR), anal discharge, inflammation and tenderness, and healing of fissure, was recorded in structured proforma, was carried out using the Statistical Package for the Social Sciences. A Friedman test for repeated measures, followed by Wilcoxon post hoc test, was conducted on the study variables. Results with P-value<.01 were considered significant.

RESULTS:

Data of 15 patients was used for analysis. Complete healing of the fissure was documented in 93% of patients by the end of their respective 30th day. There was significant relief in symptoms of inflammation, tenderness, anal discharge, and bleeding per rectum (BPR) in most of the patients within their first 7 days of treatment. Median pain level assessed on VAS was significantly reduced from 9 (on the 1st day) to 1 (on the 7th day) and eventually to 0 on the 30th day. Statistically significant difference was observed in the percentage healing of fissure measured on the 8th day (78 ± 11.464), 15th day (91.33 ± 9.904), and 30th day (99.33 ± 2.582).

CONCLUSION:

The observatory report provides significant elementary evidence on the effectiveness of an Ayurvedic conservative treatment in managing acute and chronic primary fissure in ano.
Management of non-ischemic central retinal vein occlusion with cystoid maular edema through Ayurveda interventions
Authors: Sugunan Vidya , Namboothiri Narayanan Narayanan , Kumar Aravind , Sukumaran Krishnendu , Varma Kavya Rama
Published: September 2023

Introduction:

Central retinal vein occlusion (CRVO) is clinically classified into ischemic and non-ischemic varieties. Non-ischemic CRVO presents with the blurring of vision and posterior segment findings such as hemorrhages, tortuous blood vessels, cotton-wool spots, and macular edema. Sometimes, cystoid macular edema may be present.

Patient Information:

A 30-year-old man was diagnosed with non-ischemic CRVO and cystoid macular edema in his right eye. The patient had taken multiple rounds of intraocular injection. The visual acuity of the patient was LogMAR 0.602 in his right eye and LogMAR 0 in his left eye. Posterior segment examination of the patient showed cotton-wool spots, tortuous blood vessels, and some hemorrhages. Optical coherence tomography showed multiple cyst-like lesions at the macula. The patient was treated with four courses of inpatient therapy comprising Ayurveda oral medicines (Kvatha, Churna, and Gutika), Kriyakalpa (local ophthalmic therapies such as Seka, Ashchyotana, Pindi, and Bidalaka), and treatments for the head such as Siroveshtana and Lepa. After treatment the visual acuity readings of the patient was improved, and most of the posterior segment findings were found resolved.

Conclusion:

The patient experienced positive changes from the treatment. Ayurvedamanagement can be a therapeutic option for non-ischemic CRVO and cystoid macular edema.
Effect of Ayurveda interventions Vallibadara [Ziziphus oenoplia (L.) Mill.] and Avipattikara Churna in the management of Mukhadushika (acne) - a case report
Authors: Purohit Payal J. , Acharya Rabinarayan
Published: September 2023

BACKGROUND:

The spine of Vallibadara [Ziziphus oenoplia (L.) Mill.] of family Rhamnaceae are traditionally claimed to manage Mukhadushika (acne vulgaris). In Ayurveda, Avipattikara Churna is known for its Pitta Shamka and mild laxative action. The vitiation of Pitta Dosha and constipation are also contribute to manifestation of acne.

PATIENT INFORMATION AND INTERVENTION:

A 19 year old patient presented with complaints of papules and pustules, scattered all over her forehead and cheeks since last one year. The patient also reported constipation and heartburn since many months. She was diagnosed with Mukhadushika and was treated with the local application of the paste of powdered thorn of Z. oenoplia mixed with lemon juice and oral administration of Avipattikara Churna 4 gm twice daily with water for 21 days.

RESULT:

Considerable reduction was observed in the scattered papules and pustules on the forehead and cheeks of the patient. Constipation and burning sensation in the chest were relieved after one week. Complete relief in symptoms was noticed after 21 days of treatment. No recurrence of eruptions was observed during the follow-up after 30 days.

CONCLUSION:

The external application of spine of Z. oenoplia and internal administration of Avipattikara Churna are effective in the treatment of acne vulgaris.
Ayurvedagranthasamuccayah
Authors: Lavaniya Vinod Kumar , Sharma Madan Mohan , Thrigulla Saketh Ram , Narayanan Vatakkathillath Rakesh , Chincholikar Mukesh Bhagwanrao , Ashwathykutty Vijayan , Kumar Adarsh , Srikanth Narayanam
Published: September 2023

Ayurvedagranthasamuccayah is a web portal developed by the Central Council for Research in Ayurvedic Sciences (CCRAS) wherein all the major classical compendiums of Ayurveda are made available on a web-based platform to enable students, practitioners, academicians, and researchers of Ayurveda to have readily accessible and searchable information. The key features of the portal include easy navigation of books with the help of list-based dropdowns and arrow buttons, various scripts to suit the reading purpose of the reader, search facility for any particular term in all the books simultaneously, and results in Key Word in Context format, search function up to five terms simultaneously, and edutainment tools such as Shalaka pariksha and “Random Sutra” for testing and improving one’s knowledge. To increase awareness of the Āyurvedagranthasamuccayah, this short communication outlines the capabilities and utility of the web-based platform.
Management of secondary amenorrhea and PCOS by Vamana and Virechana - a case report
Authors: Prarthana T. , Rao Veena G.
Published: September 2023

A 34-year-old female patient presented with a prolonged history of absence of menstruation and dyspareunia was clinically diagnosed as Artava Kshaya (amenorrhea). She was treated with Vamana Purva Snehapana (oral ingestion of fats) with Guggulutikta Ghrita and Aragvadha Mahatikta Ghrita followed by Vamana (emesis therapy) and Mahakalyanaka Ghrita Snehapana followed by Virechana (purgation therapy). On the 15th day after Shodhana and Samsarjana Karma (dietetic regimen after therapeutic purgation), the menstrual cycle appeared after ten years. The patient weight was reduced by 5 kg after the completion of therapeutic emesis and purgation. Symptomatic improvement was observed in concurrent symptoms such as dyspareunia and puffiness of the face. The patient was observed for the next two years without any therapeutic intervention, and she had regular menstrual cycles with moderate flow during that period. This case demonstrates the role of Vamana and Virechana in the management of Artava Kshaya.
Interception of fistulous tract and application of Kshara Sutra: Boon for anal fistulae with scrotal extension: A case series
Authors: Hanifa Nasreen , Sherkhane Rahul
Published: September 2023

Anal fistula primarily occurs due to infection of intersphincteric anal glands. In some cases, the anal fistula can extend into the scrotum. Fistula-in-ano with scrotal extension is a rare condition, and at first glance, such a presentation may be confused with acute scrotal diseases. It is commonly a congenital disorder in children characterized by painful swelling, redness, and pus discharge from the scrotum’s external opening (secondary orifice). Acharya Sushruta mentioned Ksharasutra therapy for managing Bhagandara (fistula-in-ano), a popular method for fistula-in-ano management with a reasonable success rate. Further, to fasten the recovery period in complex anal fistula cases, a modified technique of Ksharasutra is adopted, known as interception of fistulous tract with the application of Ksharasutra (IFTAK) technique. This case series describes three patients diagnosed with anal fistulae with scrotal extension. All patients had previously undergone a failed surgical procedure to cure their fistula. The patients were operated on with the IFTAK technique after proper preoperative evaluation. The postoperative fistulous wound in two cases was cured entirely within 5 weeks, and the third case within 6 weeks of treatment. IFTAK technique has shown promising outcomes in patients with anal fistula with scrotal extension. The success of the treatment with IFTAK is due to the eradication of sepsis by proper interception of the fistula tract. However, the efficacy of the IFTAK technique should be validated through well-planned randomized controlled clinical trials for its implementation as a standard treatment for complex anal fistulae.
Safety and efficacy of Rudraksha Churna in the treatment of essential hypertension—a single-arm multicentre trial
Authors: Kumawat Vinod Bihari , Yadav Babita , Vijayan Ashwathykutty , Jain Avinash , Das Jeuti Rani , Sharma Bhagwan Sahai , Khanduri Shruti , Rana Rakesh , Singhal Richa , Maheshwar Thugutla , Srikanth Narayanam , Dhiman Kartar Singh
Published: September 2023

BACKGROUND:

Essential hypertension (EHTN) is one of the most prevalent lifestyle disorders globally. In Ayurveda, the powdered seed of Elaeocarpus ganitrus Roxb. ex G.Don [Rudraksha Churna (RC)] is indicated for headache, the most common symptom of EHTN. Pharmacological studies on an aqueous extract of E. ganitrus have shown that it can be used to treat anxiety and EHTN. However, no research has been done on the therapeutic efficacy of RC in the treatment of EHTN. Therefore, the present study was designed to evaluate the safety and efficacy of RC in the treatment of EHTN.

MATERIALS AND METHODS:

The multicentre single arm trial was conducted at the Regional Ayurveda Research Institutes at Jaipur and Itanagar. A total of 150 individuals who met the screening criteria were enrolled in the trial after obtaining written informed consent. The participants were administered two 500 mg capsules of RC twice daily (2 g daily) with water for 12 weeks. The outcome measures were reduction in blood pressure, improvement in Hamilton Anxiety Rating Scale Score (HAM-A), SF-36-Health Survey Questionnaire (HSQ), visual analog scale for headache, anxiety, dizziness, tinnitus, fatigue, and amelioration in clinical parameters at every 14-day interval during the trial period of 98 days comprising 84 days of treatment and 14 days of follow-up.

RESULTS:

The results showed a significant decrease in mean systolic and diastolic blood pressure (P < 0.001). Significant relief (P < 0.001) was also observed in outcome measures such as headache, anxiety, dizziness, fatigue, shortness of breath, palpitation, HAM-A, and HSQ score. Safety parameters such as liver function tests and renal function tests were within the reference range during the study, indicating the therapeutic safety of RC.

CONCLUSION:

EHTN and its symptoms can be managed with RC. However, double-blind RCTs with adequate sample size may be planned to validate the findings of this study before generalizing the study results.
Management strategies and critical appraisal of age-related macular degeneration (AMD)
Authors: Bhavya Bandahalli Madhusudhana Rao , Doddamani Shashidhar H. , Kumar Rajendra
Published: September 2023

INTRODUCTION:

Age-related macular degeneration (AMD) is a degenerative disease of macula associated with aging. It is the most leading cause of the central vision loss and blindness in the developed countries above the age of 55 years.

OBJECTIVES:

The aim of this article is to critically analyze and to provide quality evidence in view of safety, efficacy, and effectiveness of Ayurveda interventions.

MATERIALS AND METHODOLOGY:

The study reviewed randomized controlled trials (RCTs), non-RCTs, and case studies on the management of AMD in Ayurveda. They were retrieved through Ayurveda research databases and Medical Journal databases such as MEDLINE, SCOPUS, Web of Science, and other directories of open access journals. Hand searching was done using predefined search terms. The search was limited to articles published till July 2021. Study selection followed the symptomatology of AMD. The data were documented and extracted using study ID and design, sample size, duration, interventions, outcomes, and result. The quality and the risk of bias assessment were done using available tools. Quantitative synthesis was not attempted as we aimed at only systematic review.

RESULTS:

There were 28 screened records of which 6 fulfilled pre-defined criteria. Most commonly adopted therapeutics include four studies on Nasya (medication through nose), five on Tarpana (lubrication of eye), and two studies focussing on Basti (therapeutic enema) as primary management. The results were categorized under Shodhana (purification therapy) and Shamana (palliative). Overall studies show a significant improvement in subjective parameters assessed through gradation index. Panchakarma combined with eye treatment showed better relief.

CONCLUSION:

The study outcome yielded considerable improvement in vision and also assisted in maintaining existing vision which is greatly appreciable in addressing the subject’s quality of life by controlling further progression of the disease.
Using Yoga Nidra practice as Nidra enhancing strategy: A perspective
Authors: Datta Karuna , Kanitkar Madhuri
Published: September 2023

Yoga Nidra, a Yogic method called dynamic sleep, is a systematic method of bringing about complete physical, mental, and emotional relaxation. In this state, relaxation is achieved by turning inwards, away from outer experiences. While doing Yoga Nidra, electro-encephalography, electro-myography, and electro-oculography were recorded, and the epochs were scored as per the standard guidelines. The entire practice showed the individual to be awake. However, areas in the brain showed an increase in the power spectra density of the “delta” waves, implying the individual was awake, but there was evidence of “local sleep.” There is a need to use this ancient strategy to maximize performance, both physical and cognitive, and help sleep better. In a post-pandemic world where sleep problems are common, a relatively easy-to-do practice may significantly help reduce the allostatic load of sleep problems on lifestyle disorders. In addition, it may be an innovative strategy to improve critical decision-making for high performers.
Efficacy and safety of Ayurveda interventions for diabetes mellitus—a systematic review protocol
Authors: Kale Shyam Gyanoba , Kachre Kalpana Budhaji , Mahajan Bidhan , Dave Parth Prakashbhai , Ahmad Azeem , Suryawanshi Milind , Rao Bhogavalli Chandrasekhar , Srikanth Narayanam
Published: September 2023

INTRODUCTION:

Ayurvedic treatments are in use to treat Diabetes Mellitus (DM), either as a stand-alone treatment or as an adjunct to conventional care. There is need for a comprehensive assessment of the efficacy and safety of Ayurvedic interventions in DM through a systematic review. Therefore present work is planned to create quality based evidence on the efficacy and safety of Ayurvedic intervention for DM.

MATERIALS AND METHODS:

The data for systematic review will be collected by a comprehensive search of databases will be made to get maximum research articles on clinical trials such as randomized, non-randomized controlled, multiple arm, and quasi-randomized controlled trials. The primary outcome will be treatment response on improvement in subjective criteria, i.e. associated symptoms with DM, effect on fasting blood glucose level, postprandial blood glucose level and HbA1C level. The secondary outcome will be the assessment of the health-related quality of life and safety of interventions. For the systematic review three reviewers will extract the data separately in a pre-determined format. For each included study, a narrative synthesis will be conducted. A meta-analysis will be performed if the collected data is suitable for meta-analysis.

CONCLUSION:

The systematic review serves as a representative of the evidence of safety and efficacy of Ayurveda interventions in treating DM. Outcome of the review may also provide scope for planning further researches.

PROSPERO STUDY REGISTRATION NO:

PROSPERO 2020 CRD42020159659
Efficacy of Ksharasutra prepared through automated machine and manual process in fistula-in-ano
Authors: Rai Amit K. , Yadav Babita , Panigrahi Hemanta K. , Singhal Richa , Chandrasekhararao Bhogavalli , Rana Rakesh K. , Srikanth Narayanam
Published: September 2023

BACKGROUND:

The manufacturing process of Ksharasutra is still predominantly manual, even in the current era. It inherently leads to small-scale production and restricted availability of this effective treatment. CCRAS has developed a prototype of an automated machine to manufacture the Ksharasutra on a large scale.

OBJECTIVE:

This clinical study will investigate the safety and efficacy of the Ksharasutra prepared through the automated machine and compare its efficacy with the manually prepared Ksharasutra.

MATERIALS AND METHODS:

This study is a double-blind, randomized controlled, parallel-group trial being conducted at the Central Ayurveda Research Institute, New Delhi. A total of 100 participants will be enrolled in the study. Individuals of any sex aged 18–60 years and diagnosed with fistula-in-ano complaining of perianal discharge, pain, tenderness, itching, and induration will be enrolled in the trial. The enrolled participants will be managed by the automated machine-prepared Ksharasutra in the trial group and the manually prepared Ksharasutra in the control group. The Ksharasutra will be changed every week till the fistula tract is completely cut off. The outcome measures include the change in the quality of life (assessed through the SF-36 questionnaire), unit cutting time of the fistula tract, the proportion of participants having complete healing of the fistula tract, and the incidence of adverse events.

DISCUSSION:

The conventional surgical treatment of fistula-in-ano is associated with a significant recurrence rate and a high risk of impaired anal continence. Compared with conventional treatment, Ksharasutra therapy is simple, cost-effective, and associated with minor post-operative care, minimal complications, and a low recurrence rate. However, small-scale manufacturing due to manual preparation, non-uniformity of techniques involved in the manufacturing of Ksharasutra, and so on limits the availability and quality of this therapy. Awareness regarding the benefits of Ksharasutra therapy and availability of surgeons experienced in this procedure can play a significant role in improving the accessibility of this para-surgical technique.

TRIAL REGISTRATION:

CTRI/2021/12/038414, dated 3 Dec. 2021
Investigation of the Complex Structure between the Severity of Alzheimer'S Disease and Influencing Factors Using Latent Class Cluster Analysis
Authors: Yildirim Didem Derici , Kiraz Mumine Bozdag , Tasdelen Bahar , Ozge Aynur
Published: September 2023

Objective:

The cognition of Alzheimer's disease (AD) has a heterogeneous pattern. It is useful to obtain more information about specific subgroups of patients to prevent disease progression. For better identification of the population, we aimed to detect latent groups based on cognitive test scores using latent class (LC) cluster analysis and influencing factors of latent severity groups to assist practitioners in outpatient departments who have restricted time and instrumentation.

Materials and Methods:

Data for 630 patients with AD in the Mersin University Dementia Outpatient Unit were collected, and cognitive test scores, demographic variables, and other factors such as comorbidities and family history of dementia were obtained. Initially, LC cluster analysis was performed to distinguish subgroups considering clinical dementia scores, age, and sex as covariates. Second, univariate analysis was used to detect the relationship between latent subgroups and influencing factors. Finally, multinomial logistic regression was performed to identify the magnitude of risk for significant factors.

Results:

Four severity groups were defined as mild, moderate, severe, and very severe cases of AD, and severity was significantly related to educational level, hyperlipidemia, diabetes mellitus, and sarcopenia (P < 0.001, P = 0.001, P = 0.043, and P < 0.001, respectively). Family history also influenced severity (P = 0.024). Disease severity increased with decreased education levels. Family history predicted a 1.555-fold increase in the risk of being in the moderate group versus the mild group. Moreover, diabetes mellitus predicted a 3.690-fold increase of being in the very severe group versus the mild group.

Conclusion:

LC cluster analysis is effective for determining severity groups for AD, and study results will help prepare a guide for an optimum evaluation tool for the disease.
EAEFA: An Efficient Energy-Aware Task Scheduling in Cloud Environment
Authors: Kumar M. Santhosh , Kumar Ganesh Reddy
Published: September 2023

The scheduling of tasks in the cloud is a major challenge for improving resource availability and decreasing the total execution time and energy consumption of operations. Due to its simplicity, efficiency, and effectiveness in identifying global optimums, electric fish optimisation (EFO) has recently garnered a lot of interest as a metaheuristic method for solving optimisation issues. In this study, we apply electric fish optimisation (EAEFA) to the problem of cloud task scheduling in an effort to cut down on power usage and turnaround time. The objective is to finish all tasks in the shortest possible time, or makespan, taking into account constraints like resource availability and task dependencies. In the EAEFA approach, a school of electric fish is used to solve a multi-objective optimization problem that represents the scheduling of tasks. Because electric fish are drawn to high-quality solutions and repelled by low-quality ones, the algorithm is able to converge to a global optimum. Experiments validate EAEFA's ability to solve the task scheduling issue in cloud computing. The suggested scheduling strategy was tested on HPC2N and other large-scale simulations of real-world workloads to measure its makespan time, energy efficiency and other performance metrics. Experimental results demonstrate that the proposed EAEFA method improves performance by more than 30% with respect to makespan time and more than 20% with respect to overall energy consumption compared to state-of-the-art methods.
Second order cumulants: Second order even elements and $R$-diagonal elements
Authors: Arizmendi Octavio , Mingo James A.
Published: September 2023

We introduce

R

-diagonal and even operators of second order. We give a formula for the second order free cumulants of the square

x^2

of a second order even element in terms of the second order free cumulants of

x

. Similar formulas are proved for the second order free cumulants of

aa^*

, when

a

is a second order

R

-diagonal operator. We also show that if

r

is second order

R

-diagonal and

b

is second order free from

r

, then

rb

is also second order

R

-diagonal. We present a large number of examples, in particular, the limit distribution of products of Ginibre matrices. We prove the conjectured formula of Dartois and Forrester for the fluctuations moments of the product of two independent complex Wishart matrices and generalize it to any number of factors.
Degeneration of a graph describing conformal structure
Authors: Bogatyrev Andrei Borisovich
Published: September 2023

We consider the cell decomposition of the moduli space of real genus $2$ curves with marked point on the unique real oval. The cells are enumerated by certain graphs, whose weights describe the complex structure on the curve. We show that the collapse of an edge in a graph results in a root-like singularity of the natural map from the weights on graphs to the moduli space of curves.
Bibliography: 24 titles.
Diophantine exponents of lattices and the growth of higher-dimensional analogues of partial quotients
Authors: Bigushev Elmir Rufkatovich , German Oleg Nikolaevich
Published: September 2023

A three-dimensional analogue of the connection between the exponent of the irrationality of a real number and the growth of the partial quotients of its expansion in a simple continued fraction is investigated. As a multidimensional generalization of continued fractions, Klein polyhedra are considered.
Bibliography: 12 titles.
On a class of interpolation inequalities on the 2D sphere
Authors: Zelik Sergey Vital'evich , Ilyin Aleksei Andreevich
Published: September 2023

We prove estimates for the $L^p$-norms of systems of functions and divergence-free vector functions that are orthonormal in the Sobolev space $H^1$ on the 2D sphere. As a corollary, order sharp constants for the embedding $H^1\hookrightarrow L^q$, $q<\infty$, are obtained in the Gagliardo-Nirenberg interpolation inequalities.
Bibliography: 25 titles.
Emil Iugan: „Trebuie să iau din pădure ceea ce îmi dă silvicultura, nu ce vreau eu”
Authors: Ciornei Laurențiu
Published: September 2023

Dacă la examenele de Bacalaureat ar fi impusă o probă specifică precum Bioeconomia, cu siguranță că multe dintre temele principale ar fi generate de activitatea economică a lui Emil Iugan, așa cum se dau azi subiecte din operele literere ale lui Liviu Rebreanu sau George Coșbuc. Năsăudean, ”fiu de oameni gospodari, crescători de animale și manager înnăscut”, așa cum este adesea prezentat de prof. univ. dr. Radu Rey, membru de onoare al Academiei Române, antreprenorul Emil Iugan a dezvoltat, pe Valea Ilvei, un model de business remarcabil. Despre Montana Iugan Silvania (MIS) se poate spune că reprezintă o paradigmă economică care își propune să creeze o economie circulară și durabilă, în care resursele biologice sunt folosite eficient și se minimizează impactul asupra mediului.Aici, bioeconomia se concentrează pe transformarea resurselor biologice într-o gamă largă de produse și soluții inovatoare, inclusiv alimente, combustibili, materiale sustenabile și biomateriale. În principal, toată această industrie impusă de Emil Iugan se bazează pe principiile solide ale bioeconomiei precum biotehnologia, ingineria genetică, agricultura sustenabilă, silvicultura durabilă și managementul adecvat al resurselor naturale. Emil Iugan a dovedit, încă acum mai bine de un deceniu, că bioeconomia reprezintă o oportunitate importantă de a răspunde noilor provocări de mediu, garantând nu numai o sustenabilitate sporită, dar și sprijinirea dezvoltării rurale, o potențială reducere a emisiilor de gaze cu efect de seră, o sustenabilitate sporită a ciclului de producție și răspândirea inovației industriale de-a lungul întregului lanț de valoare.Am fost la Lunca Ilvei și am văzut cum lucră împreună rotițele angrenajului dezvoltat de Emil Iugan pentru ca una dintre cele mai importante companii românești, campioană în industria lemnului, să facă și să mențină demnă performanța economică.
Curiosity, power and narrative practice
Authors: Zurn Perry , Meader Zan
Published: September 2023

What are some of the dominant and alternative stories of curiosity? How
do we wield it and to what effect? What does it mean to attend to the
politics of curiosity in our lives and work and to acknowledge it as a
collective practice and social force that can colonise, normalise and divide
us and disrupt, liberate and connect us? Zan Maeder interviews Perry Zurn,
Provost Associate Professor of Philosophy at American University and author
of Curiosity and power: The politics of inquiry (2021) about work tracing
histories of curiosity in philosophy and political theory and co creating
(with many other transgressors, past and present) possibilities for ethical
and liberatory curiosity praxis.
Addicted to Life
Authors: Newman David , Rapaport Pola
Published: September 2023

David Newman lives and works on the lands of the Gadigal people, also
known as Sydney, Australia. He is a faculty member of Dulwich Centre and an
honorary clinical fellow at The University of Melbourne’s Department of
Social Work. Through his independent therapy practice, Sydney Narrative
Therapy, he meets with individuals, couples and families. He delights in
this work and narrative practices have offered invigorating company
Abbreviations
Authors: Faure Michael
Published: September 2023

The Elgar Encyclopedia of Environmental Law is a landmark reference work, providing definitive and comprehensive coverage of this dynamic field. The Encyclopedia is organised into 12 volumes around top-level subjects – such as water, energy and climate change – that reflect some of the most pressing issues facing us today. Each volume probes the key elements of law, the essential concepts, and the latest research through concise, structured entries written by international experts. Each entry includes an extensive bibliography as a starting point for further reading. The mix of authoritative commentary and insightful discussion will make this an essential tool for research and teaching, as well as a valuable resource for professionals and policymakers.Michael Faure
Human health and the WTO
Authors: Petersmann Ernst-Ulrich
Published: September 2023

The Elgar Encyclopedia of Environmental Law is a landmark reference work, providing definitive and comprehensive coverage of this dynamic field. The Encyclopedia is organised into 12 volumes around top-level subjects – such as water, energy and climate change – that reflect some of the most pressing issues facing us today. Each volume probes the key elements of law, the essential concepts, and the latest research through concise, structured entries written by international experts. Each entry includes an extensive bibliography as a starting point for further reading. The mix of authoritative commentary and insightful discussion will make this an essential tool for research and teaching, as well as a valuable resource for professionals and policymakers.
Special and Differential Treatment: the relationship between environment, development and trade
Authors: Panezi Maria
Published: September 2023

The Elgar Encyclopedia of Environmental Law is a landmark reference work, providing definitive and comprehensive coverage of this dynamic field. The Encyclopedia is organised into 12 volumes around top-level subjects – such as water, energy and climate change – that reflect some of the most pressing issues facing us today. Each volume probes the key elements of law, the essential concepts, and the latest research through concise, structured entries written by international experts. Each entry includes an extensive bibliography as a starting point for further reading. The mix of authoritative commentary and insightful discussion will make this an essential tool for research and teaching, as well as a valuable resource for professionals and policymakers.
Exhaustible natural resources and Article XX(g) GATT
Authors: Marín Durán Gracia
Published: September 2023

The Elgar Encyclopedia of Environmental Law is a landmark reference work, providing definitive and comprehensive coverage of this dynamic field. The Encyclopedia is organised into 12 volumes around top-level subjects – such as water, energy and climate change – that reflect some of the most pressing issues facing us today. Each volume probes the key elements of law, the essential concepts, and the latest research through concise, structured entries written by international experts. Each entry includes an extensive bibliography as a starting point for further reading. The mix of authoritative commentary and insightful discussion will make this an essential tool for research and teaching, as well as a valuable resource for professionals and policymakers.
Export taxes and raw materials
Authors: Gao Henry , Zhou Weihuan
Published: September 2023

The Elgar Encyclopedia of Environmental Law is a landmark reference work, providing definitive and comprehensive coverage of this dynamic field. The Encyclopedia is organised into 12 volumes around top-level subjects – such as water, energy and climate change – that reflect some of the most pressing issues facing us today. Each volume probes the key elements of law, the essential concepts, and the latest research through concise, structured entries written by international experts. Each entry includes an extensive bibliography as a starting point for further reading. The mix of authoritative commentary and insightful discussion will make this an essential tool for research and teaching, as well as a valuable resource for professionals and policymakers.
Carbon leakage and WTO rules
Authors: Kleimann David
Published: September 2023

The Elgar Encyclopedia of Environmental Law is a landmark reference work, providing definitive and comprehensive coverage of this dynamic field. The Encyclopedia is organised into 12 volumes around top-level subjects – such as water, energy and climate change – that reflect some of the most pressing issues facing us today. Each volume probes the key elements of law, the essential concepts, and the latest research through concise, structured entries written by international experts. Each entry includes an extensive bibliography as a starting point for further reading. The mix of authoritative commentary and insightful discussion will make this an essential tool for research and teaching, as well as a valuable resource for professionals and policymakers.
Rules of origin, sustainability and trade
Authors: Puccio Laura
Published: September 2023

The Elgar Encyclopedia of Environmental Law is a landmark reference work, providing definitive and comprehensive coverage of this dynamic field. The Encyclopedia is organised into 12 volumes around top-level subjects – such as water, energy and climate change – that reflect some of the most pressing issues facing us today. Each volume probes the key elements of law, the essential concepts, and the latest research through concise, structured entries written by international experts. Each entry includes an extensive bibliography as a starting point for further reading. The mix of authoritative commentary and insightful discussion will make this an essential tool for research and teaching, as well as a valuable resource for professionals and policymakers.