bluuebunny/crossref_metadata_2025 huggingface dataset:
An in vitro comparative evaluation of retreatability of a bioceramic and resin sealer using cone-beam computed tomography analysis
Authors: Sharma Sumit , Raghu Ramya , Shetty Ashish , Rajasekhara Subhashini , Lakshmisetty Harika , Bharath G.
Published: September 2022

Aims:

The aim is to evaluate the retreatability of BioRoot RCS (BCS)/Gutta-percha (GP) as compared to AH Plus/GP with and without a solvent using cone-beam computed tomography (CBCT).

Materials and Methods:

Mesio-buccal canals in 48 first mandibular molars were instrumented using iRace rotary files up to size 25.4% and obturated with GP using one of the following sealers, BCS and AH Plus. Post obturation, the teeth were scanned using a CBCT. All samples were divided into four groups (n = 12). Group 1: GP/BCS was removed using D-Race retreatment files and xylene as a solvent; Group 2: GP/BCS was removed using D-Race retreatment files without xylene; Group 3: GP/AH Plus was removed using D-Race retreatment files with xylene; Group 4: GP/AH Plus was removed using D-Race retreatment files without xylene. Time taken to reach the working length (WL) was recorded. Samples were again scanned using CBCT and the remaining filling material was calculated in the coronal, middle, and apical thirds. Data were tabulated and analyzed via Kruskal–Wallis and Mann–Whitney Post hoc test (P < 0.05).

Results:

Group 3 exhibited significantly less time to reach WL as compared to Group 1. There was no significant difference between Group 2 and Group 4. In all groups, the apical third had the most remaining filling material (Group 1 – 13.75 ± 4.83, Group 2 – 18.33 ± 3.26, Group 3 – 10.42 ± 3.34, Group 4 – 15.42 ± 3.34). WL and patency were re-established in all the samples.

Conclusions:

Irrespective of the retreatment technique employed complete removal of both the sealers could not be achieved. However, retreatability of AH Plus with xylene was superior to that of BioRoot RCS.
Comparative evaluation of cyclic fatigue resistance of file systems based on different manufacturing technologies after exposure to NaOCl and multiple sterilization cycles
Authors: Malhotra Pulkit , Bansal Parul , Nikhil Vineeta , Jaiswal Shikha , Gupta Sachin
Published: September 2022

Aim:

To comparatively evaluate in vitro the cyclic fatigue resistance of different file systems based on different manufacturing technologies after exposure to NaOCl and multiple sterilization cycles.

Materials and Methods:

Sixty new Nickel − Titanium (NiTi) rotary files were selected and divided into five groups (n = 12) based on different manufacturing technology. These groups were: Protaper Universal (GPT) (DentsplyMaillefer, Ballaigues, Switzerland) Protaper Next (GPTN) (Dentsply, Tulsa, OK, USA), Twisted files (GTF) (Sybron Endo, Orange, CA, USA), Neoniti (GNL) (Neolix, France), and Hyflex CM (GHCM) (Coltene/whaledent inc., 235 Ascort Parkway, Cuyahoga falls, OH, USA). Files were sterilized in an autoclave at 121°C at 15 psi for 15 min and exposed to 5.0% NaOCl solution for 30 s before cyclic fatigue testing till instrument fracture using a standardized grooved block assembly with the artificial canal at 90° angle of curvature using a 16:1 reduction hand-piece powered by a torque-controlled motor. This whole procedure of autoclaving, immersion in sodium hypochlorite solution and rotating in a stainless steel assembly was repeated again and again until the file fractured.

Results:

The highest mean for the number of cycles before fracture was observed with Neoniti (GNL) and lowest for Hyflex CM (GHCM). The difference between GPT vs GTF, GPTvs GNL, GNLvs GHCM; GPTNvs GTF, GPTNvs GNL, GPTNvs GHCM; GTFvs GNL, GTFvs GHCM and GNL VS GHCM was statistically significant, whereas the difference between GPTvs GPTN was statistically nonsignificant.

Conclusion:

Neoniti and twisted file systems resisted the maximum number of cycles to fracture at 90° angle of curvature after exposure to 5% sodium hypochlorite solution and multiple autoclaving cycles. Hyflex CM showed the least resistance in the similar conditions.
Differences in Muscle Strength, Physical Activity, and Cardiometabolic Risk Factors between Type 2 Diabetic Patients with and Without Benzodiazepines or Antipsychotic Medications
Authors: Hamasaki Hidetaka
Published: September 2022

Objective:

This study aimed to examine differences in muscle strength, physical activity, and cardiometabolic risk factors between Type 2 diabetic patients with and without benzodiazepines (BZD) or antipsychotic drugs (APD).

Methods:

The author conducted a cross-sectional study on patients with Type 2 diabetes (T2D) whose medication history was collected, and handgrip strength (HGS) was measured. Non-BZD- or APD-users were matched one-to-one with the BZD- or APD-users with respect to their age, gender, and body mass index. The differences in HGS, physical activity, and cardiometabolic risk factors such as blood pressure, lipid profile, and glycemic control between groups were assessed.

Results:

One hundred and ninety-six patients with and without BZD and 85 patients with and without APD were enrolled. HGS and walking time were significantly lower in patients treated with BZD or APD users than those without BZD or APD. Serum triglycerides levels were higher and high-density lipoprotein cholesterol levels were lower in patients treated with APD than those treated without APD. Both BZD and APD users had a longer sleep duration than nondrug users.

Conclusion:

BZD and APD were associated with decreased muscle strength and daily physical activity, and APD could impair lipid metabolism in patients with T2D, which may result in increasing the risk of cardiovascular (CV) events. BZDs and APDs should be judiciously prescribed for patients with T2D who are at high risk of CV disease.
Cardiac Remodeling in Female Athletes with Relation to Sport Discipline and Exercise Dose – A Cardiac Magnetic Resonance Study
Authors: Małek Łukasz A. , Miłosz-Wieczorek Barbara , Marczak Magdalena
Published: September 2022

Purpose:

To compare chronic cardiac adaptations to exercise at various intensities and in different sports categories of female athletes.

Methods:

This was a retrospective study including 30 elite female athletes (members of the National Team), 14 amateur female athletes training 3-6 h per week for several years, and 20 inactive female controls who underwent cardiac magnetic resonance.

Results:

Left and right ventricular end-diastolic volumes (LVEDVI and RVEDVI) differed between all studied groups. They rose from controls to elite athletes, with amateur athletes in-between (for LVEDVI 73 ± 9 vs. 83 ± 6 vs. 95 ± 13 ml/m2, P< 0.001, for RVEDVI 74 ± 7 vs. 84 ± 6 vs. 97 ± 14 ml/m2, P< 0.001, respectively). Left and right atrial areas (LAA and RAA) were larger in amateur and elite athletes than in controls (P < 0.001), but there was no difference between the two athlete groups. The interventricular septal diameter was mildly higher only in elite female athletes (9 ± 1 mm vs. 8 ± 1 mm, P< 0.001). No difference in the above parameters was found between power and endurance athletes. Three athletes presented with benign myocardial fibrosis in the lower left ventricular (LV)-right ventricle junction point.

Conclusions:

The hearts of female athletes differed from inactive controls. Part of the changes was related to exercise intensity (LVEDVI and RVEDVI, mild LV muscle thickening), but other changes were not (LAA and RAA). There was no difference in the heart chamber size and LV muscle thickness between studied athletes engaging in power and endurance disciplines. There were also no significant myocardial tissue changes observed in both elite and amateur female athletes.
Covid-19, Long Covid, and Psychosomatic Manifestations: A Possible Burden on Existing Rheumatology Facilities
Authors: Siddiq Md Abu Bakar , Rasker Johannes Jacobus
Published: September 2022

COVID-19 mainly affects the respiratory system; however, other body parts can also be involved. After resolving the acute stage, long-standing COVID effects can continue to trouble COVID survivors; a term used to describe them is “long COVID” or post-COVID syndrome. Long COVID phenotypes are physical and functional: physical symptoms include persistent dyspnea, chest pain, myalgia, impaired mobility, and arthralgia, whereas fatigue, depression, cognitive impairment, anxiety, posttraumatic stress disorder, insomnia, and somatization are considered the functional aspects. Growing evidence suggests inflammatory rheumatic conditions may develop in COVID-19. COVID-19 further impact patients significantly with inflammatory arthritis (IA), their physical, psychological and social relationships, and their quality of life. Psychiatric COVID long-haulers could overload the existing rheumatology facilities globally, especially in the simultaneous presence of IA and COVID-19. This perspective addresses how psychosomatic manifestations of COVID-19 and “long COVID” burden the present rheumatology facility. We further address treatment options of “long COVID” and future research direction regarding its pathophysiology and “long COVID” psychosomatic illness, especially in the setting of chronic rheumatic diseases.
Impact of multimodal therapy on margin status on overall survival for patients undergoing adrenalectomy for localized adrenocortical carcinoma
Authors: Hickey Kyle , Shakir Afzal , Shepherd Caitlin , Djang Robin , Patel Sanjay
Published: September 2022

Introduction:

Adrenocortical carcinoma is a rare malignancy that typically presents with advanced features and carries a poor prognosis. Complete surgical resection offers patients the best survival outcomes, but this is not always achievable and many require additional therapy for advanced features. Some literature has explored the role of chemotherapy and radiation, but little has been conducted to explore the effects of multimodal therapy.

Methods:

We retrospectively reviewed the National Cancer Database for adults with primary nonmetastatic adrenocortical carcinoma (ACC) who underwent either partial or radical adrenalectomy. Excluded patients included those with metastatic disease and those with primary tumor >30 cm. Patients were categorized based on adjuvant treatment; chemotherapy, radiation therapy (RT), RT + chemotherapy, or no adjuvant therapy. Overall survival (OS) was compared using survival curves, log rank tests, and multivariate survival analysis.

Results:

We identified 1644 patients with localized ACC treated with adrenalectomy. The median tumor size was 10.6 cm. A total of 278 patients had positive margin status (R1), and 416 patients had nodal (pN+) disease. Out of all patients, a minority (39.4%) received adjuvant therapy, which was most commonly given as chemotherapy only. Statistically significant increase in OS was noted with the use of RT + chemotherapy in the node-negative, margins-positive (pN0/pNx; R1) subgroup versus patients who did not receive adjuvant therapy (5-year OS 60.5% and 28.2%, respectively [P = 0.002]). This held true on multivariate analysis with significant improvement in OS in the pN0/pNx; R1 population with RT + chemotherapy compared to those who received no treatment (hazard ratio: 0.40 [95% confidence interval: 0.2–0.9], P = 0.02).

Conclusions:

Our findings support the use of adjuvant chemotherapy plus RT in patients with positive surgical margins and no nodal disease. Additional studies are required to confirm these findings, clarify the objective benefit of multimodal therapy, and to determine the optimal chemotherapy/RT combination.
Investigation of Montelukast Effect on Rosuvastatin Induced Late Puberty in Rats
Authors: Aledani Tamadir Hamid Wadi , Al-Hayder Manal Nasser , Mohammed Suha Haitham , Al-Mayyahi Rawaa Salim
Published: September 2022

Background:

Puberty is a critical process for the development of sexual organs and reproductive ability. It is triggered and regulated by the hormones. Rosuvastatin can delay the onset of puberty through the inhibition of cholesterol and androgen biosynthesis. On the other hand, montelukast has protective effects against various diseases and against reproductive toxicity induced by other medications, but its effects on puberty have not been studied.

Aims:

Assessment of the protective effect of montelukast against rosuvastatin-induced delayed puberty.

Settings and Design:

At the university.

Materials and Methods:

Eighteen male Wistar rats aged 30 days and weighted 50–60 g were distributed to three groups (six rats per group) and intraperitoneally administered every day for 5 days with 0.2 ml of distilled water as control, 10 mg/kg of rosuvastatin and with rosuvastatin + montelukast (10 mg/kg for each drug). These animals’ groups were euthanised on day 50 of age to assess the effect of rosuvastatin alone and with montelukast on the serum levels of the reproductive hormones and histological manifestations and morphometric measurements of the testes.

Statistical Analysis Used:

One-way analysis of variance and Bonferroni multiple tests were performed to analyse the findings using the GraphPad Prism software.

Results:

Treatment of rats with rosuvastatin showed a significantly decreased level of testosterone and luteinising hormone as well as histopathological and morphometric alterations in the testicular tissues in comparison with the control. Interestingly, co-treatment of rosuvastatin with montelukast could not reverse or mitigate these changes induced late puberty.

Conclusion:

There is no protective effect of montelukast against rosuvastatin-induced delayed puberty.
Study of Association of Global Deoxyribonucleic Acid Methylation in Women with Polycystic Ovary Syndrome
Authors: Ray Rudra Prasanna , Padhi Maya , Jena Satyajit , Patnaik Ranjita , Rattan Roma , Nayak Ajit Kumar
Published: September 2022

Background:

Polycystic ovary syndrome (PCOS), a common endocrine disorder affecting 5%–10% of reproductive age women worldwide, associated with various metabolic morbidities. One potential molecular mechanism could be epigenetic modifications, such as deoxyribonucleic acid (DNA) methylation.

Aims:

The aim is to determine the association of global DNA methylation in peripheral blood leucocyte (PBL) cells and PCOS women. Also to assess abnormal lipid profile, insulin resistance, gonadotropins and reproductive markers in them.

Settings and Design:

The study design involves a hospital-based prospective case–control study.

Materials and Methods:

Fifty women with PCOS, diagnosed as per Rotterdam criteria and the rest 50 without PCOS or any disease, attending outpatient department were recruited. Serum biochemical markers and Global DNA methylation assay were done by using standardised kit.

Statistical Analysis Used:

Data were compared using Independent t-test or Mann–Whitney U test using IBM SPSS version 26.0. P < 0.05 was considered statistically significant.

Results:

Majority, 72% of PCOS and 82% non-PCOS women were between 20 and 25 years. Most common presenting symptom was menstrual irregularity. Women with PCOS have high serum cholesterol and triglyceride level, elevated serum luteinising hormone (LH), follicle-stimulating hormone (FSH), LH/FSH ratio and testosterone but low estradiol levels as compared to non-PCOS. Statistically significant high mean Global DNA methylation percentage was found in PBLs of women with PCOS.

Conclusion:

Despite study limitations, this study provided insight into Global DNA methylation in PBLs was associated with PCOS. It requires further research to better understand the influence of epigenetic factors including genome-wide DNA methylation profiling in PCOS development.
Comparing Progesterone Primed Ovarian Stimulation (PPOS) to GnRH Antagonist Protocol in Oocyte Donation Cycles
Authors: Khurana Rupali Khaparde , Rao Vyshnavi , Nayak Chaitra , Pranesh Gautham T , Rao Kamini A.
Published: September 2022

Background:

Progesterone-primed ovarian stimulation (PPOS) protocol is based on the principle of preventing pre-mature luteinising hormone surge during ovarian stimulation using progesterone.

Aims:

In this study, we aimed to compare the cost-effectiveness of PPOS over GnRH antagonist cycles in oocyte donor cycles where freeze all is a norm.

Settings and Design:

It is a prospective cohort study with 130 participants.

Materials and Methods:

We included all women undergoing oocyte donation using PPOS protocol and antagonist protocol at our centre. Fifty-seven belonged to the PPOS group and were given medroxyprogesterone acetate (MPA) and 73 belonged to the GnRH antagonist group who received cetrorelix. The primary outcome was the number of mature oocyte retrieved at OPU and the cost involved per stimulation cycle.

Statistical Analysis Used:

For normally distributed observations, we used t-test, and for the variables of non-normal distribution, Mann–Whitney U-test was used. The significance was accepted for P < 0.05.

Results:

The baseline clinical characteristics of the donors were comparable with a mean age of 25.42 ± 2.90 years, body mass index of 24.00 ± 4.00 kg/m2 and antral follicle count of 18.63 ± 5.23. The duration of stimulation was similar in both the groups as well as the total gonadotropin dose required was not significantly different. The number of mature oocytes retrieved was same in both the groups (10.41 ± 4.04 with antagonist and 10.25 ± 3.23 with PPOS, P = 0.964). There were no reported cases of severe ovarian hyperstimulation syndrome (OHSS) in any of the groups. The incidence of mild-to-moderate OHSS in the antagonist group was 5.4% and in the PPOS group was 3.6%, and the difference was not significant (P = 0.69). The cost per mature oocyte (M2) was significantly higher in the antagonist protocol in comparison to the PPOS protocol (INR 9485.69 ± 5751.11 vs. Rs. 5945.86 ± 2848.59, respectively, P < 0.001).

Conclusion:

Our study identifies PPOS protocol using MPA to be more cost-effective and patient-friendly than conventional GnRH antagonist protocol in oocyte donor cycles.
An Investigation of Steroid Biosynthesis Pathway Genes in Women with Polycystic Ovary Syndrome
Authors: Sharma Priyal , Jain Manish , Halder Ashutosh
Published: September 2022

Background:

Polycystic ovary syndrome (PCOS) is a common endocrinopathy whose heterogeneous genetic basis results in a variable clinical presentation. One of the main clinical features of PCOS is hyperandrogenism which occurs due to dysregulation of ovarian and adrenal steroidogenesis.

Aims:

This study aimed to investigate potentially pathogenic variants in steroidogenic genes associated with PCOS.

Settings and Design:

This was a hospital-based observational study.

Materials and Methods:

We recruited 51 women who presented with PCOS. Fasting blood samples were drawn from the participants and their whole-exome sequencing analysis was carried out to look for pathogenic variants involved in steroidogenic pathways. The variants were predicted for their probable deleterious effects on proteins through in silico prediction tools. We evaluated the variants with respect to the hormonal characteristics and clinical outcomes of the patients.

Statistical Analysis Used:

All variables were analysed using GraphPad Prism 8. Kruskal–Wallis t-test and Fisher's exact test were used to compare clinical parameters and frequency differences among PCOS patients with and without variants.

Results:

The data presented here reveal eight heterozygous exonic variants, namely CYP21A2 (p.Ala392Thr, p.Gln319Ter and p.I143N), steroidogenic acute regulatory (p.Arg53 Leu), AKR1C3 (p.Phe205Val), P450 oxidoreductase (p.Val334Ile and p.Val251Met) and HSD17B6 (p.Gly40Ser), of which three were pathogenic, and four variants of uncertain significance in 8 out of 51 patients (15.68%). The identified variants were predicted to cause protein destabilisation, thus likely contributing to the pathogenesis of PCOS. Some of the variants showed significant differences between PCOS patients and population database (P < 0.05).

Conclusion:

The results of this study add to the mutational spectrum of steroidogenic genes and their association with PCOS.
Scientific aspects of Janapadodhwansa Vyadhi (epidemic disorders) according to Ayurveda in the context to Jwara—an epidemiological and Trisutra-based approach
Authors: Joglekar Aishwarya A. , Vyas Mahesh K. , Bhojani Meera K.
Published: September 2022

Background:

Ayurveda was oriented with the management of various epidemic-like situations. Acharya Charaka has explained the concept of Janapadodhwansa (~the destruction of human community at a large scale) in Vimanasthana of the treatise Charaka Samhita. The concept of Janapadodhwansa is a mirror of the disease origin, spread, and control in the population.

Aim:

The aim was to critically analyze the concepts of Janapadodhwansa and epidemiology in the purview of Ayurveda and contemporary research.

Materials and Methods:

The concepts of epidemiology were critically analyzed in the purview of the concept of Janapadodhwansa in Ayurveda. The robust search of literature from research databases, published literature, and contemporary sciences was done to incorporate the related aspects.

Observations:

The major Hetu (~etiological factors) in the manifestation of Janapododhwansa can be correlated with the environmental, host, and agent components of the epidemiological triad. The four Hetu namely Vayu (~ air), Jala (~water), Desha (~environmental pollution), and Kaala (~seasonal impact) focus largely on the environment aspect of epidemiological triad, which includes host, agent, and environment, whereas the Adharma (behavioral factors) deals with the host and agent aspects. The management of epidemics explained in Ayurveda covers all the aspects of physical, mental, social, and spiritual health facilitating the promotion and preservation of health during such conditions. Jwara (~fever) is described as a condition representing the primary presentation of Janapadodhwansa, whereas other modalities such as Rasayana Sevana, Sadvritta are also rightfully discussed.

Conclusions:

The aspects of origin and spread of diseases like Jwara (~fever) as mentioned under the umbrella of Janapadodhwansa are similar and applicable to concepts of epidemiological triad and epidemiology in general.
Evaluation of Standard Dosing for Selected Broad-Spectrum Hydrophilic Antibiotics in Critically Ill Patients with Augmented Renal Clearance
Authors: Almutairi Majed , Sulaiman Khalid Al , Enazi Sultan Al , Vishwakarma Ramesh , Aljuhani Ohoud
Published: September 2022

Background:

Inappropriate antibiotic dosing in critically ill patients with augmented renal clearance (ARC) may be associated with pathogens' resistance and worse outcomes. Unfortunately, studies regarding the relationship between ARC and clinical outcomes in patients treated with antibiotics are scarce. This study aims to evaluate selected broad-spectrum hydrophilic antibiotics' effectiveness and clinical outcomes in ARC critically ill patients with confirmed infections.

Methods:

A retrospective a retrospective cohort study in adult critically ill patients who were admitted to intensive care units at King Abdulaziz Medical City, Riyadh, and received standard dosing of selected broad-spectrum hydrophilic antibiotics (meropenem, imipenem, or piperacillin/tazobactam) with confirmed infection. All the patients who met our eligibility criteria during the study period (January 1, 2018, to December 31, 2019) were included. According to the calculated creatinine clearance using the Cockcroft-Gault equation, eligible patients had been classified into two groups: ARC versus non-ARC. The primary outcome was to assess pathogen eradication at 10–14 days; other outcomes were considered secondary. Multivariate logistic and generalized linear regression analyses were used. We considered P < 0.05 statistically significant.

Results:

A total of 133 patients were included in the study; 66 patients had ARC. The distribution of infections and types of pathogens between the groups were similar. The pathogen eradication at 10–14 days was similar between the two groups (odds ratio [OR] 1.08; 95% confidence interval [CI], 0.41–2.78; P = 0.88). Moreover, the odds of resistance development and persistence after three days were not significantly different between the two groups ([OR 0.78; 95% CI, 0.25–2.40; P = 0.66] and [OR 0.88; 95% CI, 0.35–2.18; P = 0.78], respectively).

Conclusion:

In terms of pathogen eradication, resistance, and persistence, ARC patients and non-ARC patients responded similarly to conventional doses of hydrophilic broad-spectrum antibiotics. To confirm our findings, further randomized controlled clinical trials are needed.
The Prevalence, Duration, and Outcome of Anosmia in COVID-19 Subjects Admitted to Two Tertiary Care Hospitals in Saudi Arabia
Authors: Sheffah Firas R. , Marglani Osama A. , Alherabi Ameen Z. , Heaphy John C. , Al-Tammas Anas H. , Al-Khatib Talal A. , Marghalani Yasir Osama , Ghazzawi Raghad A. , Tashkandi Abdullah Y. , Khayyat Samiha F. , Albeladi Majid A.
Published: September 2022

Objectives:

The objective is to investigate anosmia in patients with COVID-19 in tertiary care hospitals in two major cities in the Kingdom of Saudi Arabia to determine its prevalence, clinical characteristics, duration, and outcome.

Methods:

A retrospective study on COVID-19 patients who are admitted to our tertiary care hospital between May and December 2020. The inclusion criteria were all patients who are admitted to our tertiary care hospital with a confirmed diagnosis of COVID-19 in this study, we enrolled 545 patients for this study.

Results:

Of the 545 contacted subjects, 277 (50.82%) answered, whereas 268 were excluded, 26 (4.8%) of which passed away. One hundred and nineteen (42.96%) subjects were female whereas 158 (57.04%) were male. The mean age was 42.81 ± 16.76 standard deviation. About 162 (58.47%) of the 277 who completed the interview had anosmia; moreover, anosmia was grouped into transient and persistent anosmia. It was persistent in 15 subjects (5.4%) and transient in 147 subjects (94.6%); the range duration of transient anosmia was 1–180 days with a median of 10 (6, 20) days (median and interquartile range). Of the 277 subjects, 148 (53.4%) had ageusia; 15 subjects (5.4%) experienced anosmia as the only symptom, and 12 subjects (4.33%) developed ageusia as the only symptom. Of all the symptomatic subjects with anosmia 162 (58.5%), and 76 (41.36%) subjects reported a subjective impact on quality of life.

Conclusion:

More than half of the COVID-19 patients in the study presented with anosmia that was transient in the majority of cases.
Use of Neural Topic Models in conjunction with Word Embeddings to extract meaningful topics from short texts
Authors: HABBAT Nassera , ANOUN Houda , HASSOUNI Larbi , NOURI Hicham
Published: September 2022

Unsupervised machine learning is utilized as a part of the process of topic modeling to discover dormant topics hidden within a large number of documents. The topic model can help with the comprehension, organization, and summarization of large amounts of text. Additionally, it can assist with the discovery of hidden topics that vary across different texts in a corpus. Traditional topic models like pLSA (probabilistic latent semantic analysis) and LDA suffer performance loss when applied to short-text analysis caused by the lack of word co-occurrence information in each short text. One technique being developed to solve this problem is pre-trained word embedding (PWE) with an external corpus used with topic models. These techniques are being developed to perform interpretable topic modeling on short texts. Deep neural networks (DNN) and deep generative models have recently advanced, allowing neural topic models (NTM) to achieve flexibility and efficiency in topic modeling. There have been few studies on neural-topic models with pre-trained word embedding for producing significant topics from short texts. An extensive study with five NTMs was accomplished to test the efficacy of additional PWE in generating comprehensible topics through experiments with different datasets in Arabic and French concerning Moroccan news published on Facebook pages. Several metrics, including topic coherence and topic diversity, are utilized in the process of evaluating the extracted topics. Our research shows that the topic coherence of short texts can be significantly improved using a word embedding with an external corpus.
ODET: Optimized Deep ELM-based Transfer Learning for Breast Cancer Explainable Detection
Authors: Zhu Ziquan , Wang Shuihua
Published: September 2022

INTRODUCTION: Breast cancer is one of the most common malignant tumors in women, and the incidence rate is increasing year by year. Women in every country in the world may develop breast cancer at any age after puberty. The cause of breast cancer is not fully understood. At present, the main methods of breast cancer detection are inefficient. Researchers are trying to use computer technology to detect breast cancer. But there are some still limitations.
METHODS: We propose a network (ODET) to detect breast cancer based on ultrasound images. In this paper, we use ResNet50 as the backbone model. We make some modifications to the backbone model by deep ELM-based transfer learning. After these modifications, the network is named DET. However, DET still has some shortcomings because the parameters in DET are randomly assigned and will not change in the experiment. In this case, we select BA to optimize DET. The optimized DET is named ODET.
RESULTS: The proposed ODET gets the F1-score (F1), precision (PRE), specificity (SPE), sensitivity (SEN), and accuracy (ACC) are 93.16%±1.12%, 93.28%±1.36%, 98.63%±0.31%, 93.96%±1.85%, and 97.84%±0.37%, respectively.
CONCLUSION: It proves that the proposed ODET is an effective method for breast cancer detection.
Longitudinal Evaluation of a Deprescribing Protocol in Skilled Nursing Facilities
Authors: Morley Christopher P. , Schad Laura A. , Cerio Halle , McNamara Sarah E. , Wojtowycz Martha A. , Smith Nancy H. , Noviasky John A. , Ulen Kelly R. , Townsend Kimberly , Amidon Joel , Brangman Sharon A.
Published: September 2022

Objective:To determine whether a deprescribing effort reduced several key classes of medications, and the overall number of medication classes per patient, among long-term residents of skilled nursing facilities (SNFs).Design:Retrospective, longitudinal pre/post evaluation. Data from before and during the implementation of the deprescribing effort (2017 through 2019) were compared with data from the post-intervention year (2020).Setting and Patients:Long-term resident data reported through annual comprehensive reviews conducted at two SNFs located in central New York State between 2017 and 2020 (N = 12,144).Interventions:Multifaceted, interdisciplinary deprescribing effort to reduce medications in SNF residence including clinician education, guideline development, and individual chart reviews began in 2019.Results:The mean number of medications prescribed per resident was lower at both facilities after the intervention (mean = 1.74 at both facilities) versus preintervention (1.90 at Facility 1, 1.86 at Facility 2). Significant decreases were observed in the usage rates for diuretics (-4.2%;P= 0.001), opioids (-3.8%;P= 0.001), and antipsychotics (-2.4%;P= 0.010). The raw antidepressant usage rate increased by 1.5% after the intervention but the change was not significant. Effects were robust to covariate adjustment.Conclusion:A combined, comprehensive approach to deprescribing was associated with a reduction in the overall number of medication classes per resident and in several key classes of medications. Additional research with more data and covariate control is in progress for verification of these findings.
Sv. Bonaventura: Kako se različne umetnosti zvajajo na teologijo; O trojni poti; recenzija
Authors: Iljaš Domen
Published: September 2022

Knjiga, ki ji je posvečena pričujoča recenzija, prinaša prevod dveh krajših Bonaventurovih del, O trojni poti (De triplici via) in Kako se različne umetnosti zvajajo na teologijo (De reductione artium ad theologiam). Prevedla ju je filozofinja in klasična filologinja Nena Bobovnik, ki na KU Leuven pripravlja doktorat iz srednjeveške filozofije. Poleg spremne besede z naslovom »Zaris srednjeveške in skicaBonaventurove filozofije« sta še dva uvoda v piščevo misel. Najprej tri kateheze, ki jih je papež Benedikt XVI. – ki se je na Bonaventurovo teologijo zgodovine osredotočil v habilitacijski nalogi – spomladi leta 2010 posvetil svojemu »prijatelju«, kot se sam izrazi; nato pa še esej »Teološko-filozofska hermenevtika pri sv. Bonaventuru in njen pomen za današnji čas«, ki ga je pripravil Branko Klun s Teološke fakultete UL.
A Feasibility Study on Application of Eulerian Path Concept to Design of Water Supply Pipe Network
Authors: Yoon Sukmin , Kil Hong Rae , Choi Doo Yong , Kim Jong-Oh , Park No-Suk
Published: September 2022

Objectives : This study attempted to investigated the advantages that can be obtained by applying the concept of ‘Eulerian path’ called ‘one-touch drawing’ to the block type water supply network which actually has been operating in Korea.Methods : This study applied the ‘Eulerian path’ concept to an actual water supply network, and suggested simple C language program for searching adjacency matrix. Five Eulerian path based design scenarios were derived using the C language program. The pressure and residual chlorine distribution pattern of five design scenarios and the existing small block network were simulated using EPANET and compared each other. Also, by comparing all scenarios construction costs, the economic feasibility related to initial investment cost was reviewed.Results and Discussion : Five Eulerian path scenarios with two or more closed pipe loops were suggested using the C language program checking out adjacency matrix. One of them(scenario 5) consists of 7 closed pipes that can supply water to all nodes even if the number of pipes is reduced by about 10, and an increase in residual chlorine concentration of about 0.01 mg/L can be predicted at each node. In addition, it is expected that the initial investment cost of Scenario 5 can be reduced by about 23%, compared to the initial investment cost of the existing small block.Conclusion : Therefore, by applying the concept of an Eulerian path to the design of a water supply pipe network, it is possible to economically eliminate meaningless pipes while maintaining the redundancy of water supply.
New Solvable System of 2 First-Order Nonlinearly-Coupled Ordinary Differential Equations
Authors: Calogero Francesco , Payandeh Farrin
Published: September 2022

In this short communication we introduce a rather simple autonomous system of
2 nonlinearly-coupled first-order Ordinary Differential Equations (ODEs), whose
initial-values problem is explicitly solvable by algebraic operations. Its ODEs
feature 2 right-hand sides which are the ratios of 2 homogeneous polynomials of
first degree divided by the same homogeneous polynomial of second degree. The
model features only 4 arbitrary parameters. We also report its isochronous
variant featuring 4 nonlinearly-coupled first-order ODEs in 4 dependent
variables, featuring 9 arbitrary parameters.
Analysis of Effect of Internet Resources Sharing on Education Resources Balance
Authors: Dun Yanfeng
Published: September 2022

With the development of regionalization and differentiation of China's economy, the unbalanced characteristics of educational information resources in regions, urban and rural areas, key schools and non key schools are becoming more and more obvious. Insufficient information resources, unreasonable allocation of high-quality educational resources, and unfair education in the whole society are the main problems that cause this problem and need to be solved urgently. However, the current evaluation effect of the balance value of educational resources is poor, and it is impossible to accurately analyze the impact of Internet resource sharing on the balance of educational resources. Therefore, this paper analyzes the relationship between Internet resource sharing and education resource balance in detail, establishes the value evaluation model of education resources, and analyzes the impact of Internet resource sharing on education resource balance, with a view to providing some help for promoting the good sharing of Internet teaching resources and the sustainable development of education resources, and realizing the balance of education resources. With the development of regionalization and differentiation of China economic, the unbalanced characteristics of education information resources between regions, urban and rural areas, key schools and non-key schools are more and more obvious, information resources are lack and allocation of limited quality education resources are not reasonable, and the unfair education of whole society is a major problem caused this and needs to be solved urgently. The distribution of education resources in the world and even in some areas has great differences, and the traditional model of higher education development is difficult to quickly reduce the difference. Through the Internet resources sharing, education resources cannot be restricted by time and space, so it can bring the vitality to the development of higher education. It has become an important part of the balanced process of education resources. This paper mainly analyzes the correlation between Internet resources sharing and education resources balancing, and builds the value evaluation model of education resources, and analyzes the impact of Internet resources sharing on the balance of education resources.
Sin perder de vista la santa pobreza. Celebraciones de los capuchinos de Sevilla en honor de Serafín de Montegranario y del beato Bernardo de Corleone
Authors: Cabezas García Álvaro
Published: September 2022

En el otoño de 1769 la comunidad capuchina de Sevilla dedicó una octava en honor del nuevo santo Serafín de Montegranario y, seguidamente, un triduo al recién considerado beato Bernardo de Corleone. La historia institucional que años más tarde escribió el cronista fray Ángel de León ofrece una relación –aquí transcrita–, de estas fiestas, rica en detalles como el de la autoría del ornato dispuesto entonces –obra del pintor Francisco Miguel Jiménez–, o la relación de comitentes y promotores artísticos que contribuyeron a dar lustre a unos cultos que sirvieron para reafirmar la importancia de la orden capuchina en Sevilla, decidida a ocupar el vacío espiritual que dejaron los jesuitas tras su expulsión de los territorios españoles tan solo dos años antes.
Habilidades de preparación para la escuela y familias hispanas. Revisión documental
Authors: Castilleja Minerva Deyanira , López Ortega María de los Ángeles
Published: September 2022

Este estudio de revisión documental describe investigaciones recientes sobre la participación de las familias hispanas residiendo en los Estados Unidos en estrategias de apoyo a sus hijos e hijas para alcanzar habilidades de preparación para la escuela que pudieran tener un impacto en su desempeño y un impacto en la reducción de la brecha en el rendimiento académico que presentan los estudiantes hispanos en comparación con sus pares no hispanos al iniciar la escolaridad formal. Un total de 14 investigaciones dan cuenta del impacto positivo de la participación de los padres en actividades como la asistencia a programas formales de educación preescolar y visitas domiciliarias, el juego intencional y la lectura compartida como estrategias para el desarrollo de habilidades de preparación para la escuela. El análisis documental permitió identificar consideraciones relevantes como el currículo, el tipo de financiamiento y la asistencia consistente como factores relevantes en la participación en programas formales de educación preescolar.
Esclavitud moderna: Análisis de la situación de derechos humanos de las mujeres en las plantaciones de Ecuador
Authors: Tellez Patarroyo Ivonne
Published: September 2022

Este texto reflexiona sobre los derechos implicados en el fenómeno de la esclavitud moderna con un enfoque de género aplicado a un estudio de caso en Ecuador. La esclavitud moderna es un fenómeno que tiene un impacto desproporcionado en las mujeres y niñas porque siguen siendo las portadoras de los impactos negativos del crimen transnacional. El enfoque teórico proviene del Derecho Internacional de los Derechos Humanos con enfoque de género y el análisis se construyó sobre los principales puntos que representan las disparidades de género y se incorporaron tres: los roles asignados a mujeres y hombres y los recursos a los que tienen acceso en función de su sexo, las condiciones que mantienen la situación y los impactos de la disparidad. Se realizó un estudio exploratorio con métodos cuantitativos y cualitativos que permitió establecer que las estructuras sociales que rodean a las mujeres en los campamentos producen una situación de desventaja por su condición de mujeres, ya que siguen siendo incorporadas pasivamente en todos los ámbitos del desarrollo y no tienen voz en el diseño de sus vidas.
liderazgo de los mandones y su capacidad litigante
Authors: García Marisol
Published: September 2022

Buscando contribuir a la problemática de los sistemas de autoridad indígena en la Gobernación del Tucumán (Virreinato del Perú), en este artículo examinaré la figura de los mandones, indios del común promovidos a un cargo de autoridad en los pueblos de reducción. En algunas oportunidades, su liderazgo excedió el período de la designación, logrando a través de diversas estrategias consolidarse en el cargo. Analizaré el caso de Francisco Gualcusa y sus descendientes, mandones de la parcialidad de andalgalá encomendados en La Rioja a mediados del siglo XVII. Gracias a su activa capacidad litigante, recuperan parte de sus tierras originales y desarrollan una estrategia de anexión territorial. Se mostrará que, siguiendo las tendencias generales ya observadas por otros autores, el apoyo a los mandones deviene de haber garantizado el proyecto colectivo de la mayoría de los pueblos de indios: mantener la integridad territorial del pueblo, necesaria para lograr una mínima autonomía.
Lithostructural Mapping Using Landsat OLI images and Field Investigations in the Oumjrane–Boukerzia Mining District, Eastern Anti-Atlas, Morocco
Authors: Ouhoussa Lhoussayn , Ghafiri Abdessamade , Benaissi Lakhlifa , Es–sabbar Brahim , Si mhamdi Hicham
Published: September 2022

The application of remote sensing is considered to be highly efficient in the field of geology, particularly for mapping and discrimination between lithological units, as well as the identification of different surface minerals which enable the acquisition of all the optical and radar data needed to obtain more reliable and particular information, especially in inaccessible areas. Landsat 8 (Operational Land Imager) image bands, which include color compositions 7, 4, and 1, band ratios 7/5, 4/2, 3/1, and 6/3, 6/1, 5/2, Principal Component Analyses PC1, PC4, and PC3, and directional filtering at 0° (NS), 45° (NE–SW), and 90° (EW), were used to analyze the spectral characteristics of the lithological units of the study area and delineate the alteration zones which may contain significant concentrations of base metals. Combined with geological field observations, these data were integrated and analyzed in a geographic information system to establish a multi-criteria characterization of mineralized zones. Hence, the use of remote sensing contributed to the improvement and updating of available geological maps of the Oumjrane–Boukerzia area. Lineament extraction allowed for performed analyses of the structural elements that play a crucial role in the mineral distribution in the study area. Several of the targeted areas were examined in the field by selective sampling. Consequently, the results helped identify new mineralized zones with important mining potential which could be evaluated in the future through detailed geophysical and geochemical work.
The city of the future “Peshegrad” by Leo Epple: perception and evaluation of contemporaries
Authors: Алексеев Е.П.
Published: September 2022

В статье анализируется общественная реакция на архитектурный проект «Пешеград» Л.А. Эппле на основе документов из частных архивов и публикаций в советской прессе. Яркая идея самодеятельного зодчего вызвала интерес у многих представителей отечественной культуры. В 1970-х годах о «Пешеграде» писали Б.С. Рябинин и Б.А. Дижур, проект поддержали художники Д.А. Шмаринов и В.Ф. Дьяченко, профессиональные архитекторы И.М. Смоляр, Г.И. Дубровин, О.Л. Вольхин. Кинорежиссер Б.Д. Галантер рассказал об идее Эппле в фильме «Там, где твой дом» (1971), а в киноповести С.А. Герасимова «Любить человека» (1972), героями которой стали архитекторы того времени, титры идут на фоне проекта города будущего. Пешеград — детище своего времени, в нем ясно отражается культура начала шестидесятых с их «оттепельной» свободой и иллюзиями. Большинство современников воспринимали идеи Эппле не столько как рациональную градостроительную концепцию, сколько как протест против серости и бюрократии, культурной ограниченности и бездуховности.

The article analyses the public reaction to the architectural project “Peshegrad” by L.A. Epple. The study is based on documents from private archives and publications in the Soviet press. The bright idea of an amateur architect aroused the interest of many representatives of Russian culture. In the 1970s, B.S. Ryabinin and B.A. Dizhur wrote about the “Peshegrad”. The project was supported by artists D.A. Shmarinov and V.F. Dyachenko, professional architects I.M. Smolyar, G.I. Dubrovin, O.L. Volkhin. Film director B.D. Galanter told about the idea of L.A. Epple in the film “Where your Home is” (1971). Also in the film story of S.A. Gerasimov “To Love a Man” (1972), whose heroes are the architects of that time, the credits go against the background of the project of the city of the future. Pesegrad was the brainchild of its time. It clearly reflects the culture of the early sixties with their “thaw” freedom and illusions. Most contemporaries perceived Epple's ideas not so much as a national urban planning concept, but as a protest against dullness and bureaucracy, cultural limitations and lack of spirituality.