bluuebunny/crossref_metadata_2025 huggingface dataset:
WBC Count and WBC to Hb Ratio Could Predict Short-Term Recurrence Rate in Multiple Myeloma Patients Underwent Autologous Stem Cell Transplantation
Authors: Mojdeganlou Hengameh , Abbasi Ata , Asghari Rahim
Published: July 2023

Multiple myeloma (MM) is a hematologic malignancy with a variable clinical course. We investigated the prognostic role of routine laboratory factors including CBC indices and serum vitamin D levels to predict MM recurrence after receiving an autologous stem cell transplant (ASCT). 29 patients were enrolled. Before ASCT, demographic data and CBC, serum Cr, and Vit D levels were obtained. Patients underwent bone marrow aspiration (BMA) and biopsy (BMB) before ASCT and pretransplant plasma cell counts were also evaluated. Patients were followed for 6 months and BMA and biopsy were done in the 3rd and 6th month of the follow-up to detect recurrence. Overall, 9 patients were reported to have recurrence. The patient's WBC count mean was 13.3±11.6. WBC count was lower in patients with overall recurrence (P=0.005). Patients were divided into 2 groups according to WBC count (<5.5 109/L and ≥5.5 109/L) and we found that WBC count <5.5 109/L was associated with increased risk of recurrence by 15.2 times (Odds ratio: 15.2, 95%CI: 1.4-168, P=0.005). We also evaluated Wbc to Hb ratio (Wbc/Hb) and found that Wbc/Hb <1 had a significant statistical relationship with overall recurrence (P=0.026) as patients with WBC/Hb <1 were in 9.8 times increased risk of recurrence (Odds ratio:9.8, 95% CI: 2-93.5, P=0.026). pretransplant WBC <5.5 109/L and WBC/Hb <1 were associated with 9.8 and 15.2 times increased risk of myeloma recurrence and could be useful predictive factors for a patient's short-term recurrence.
L-Carnitine Promotes Cardiomyogenic Differentiation of C-Kit+Bone Marrow Progenitor Cells via MAPK-ERK Signaling Pathway
Authors: Daneshrad Tina , Fathi Ezzatollah , Farahzadi Raheleh
Published: July 2023

Many studies have shown that bone marrow (BM) stem/progenitor cells have the highest probability of cardiomyocyte differentiation. Regarding the major role of C-kit+ BM stem cells in cell therapy of patients with heart disease and getting cells with higher differentiation potential, this study aimed to investigate the capacity and effect of L-carnitine (LC) on cardiomyogenic differentiation of C-kit+ BM cells through MAPK/ERK signaling pathway. For this purpose, C-kit+ was enriched from the BM mononuclear cell population using a magnetic activating cell sorting technique. The purity of the separated C-kit+ cells was then evaluated by flow cytometry. In the next step, C-Kit+ cells were treated in a cardiomyogenic differentiation culture medium for 21 days once in the presence and once in the absence of 0.2 µM LC (the experimental and control groups). To evaluate the cardiomyogenic differentiation potential of C-kit+ cells, the Desmin cell marker was determined by immunocytochemistry. The expressions of both GATA4 and ERK proteins were measured using western blotting and flow cytometry, respectively. The results show that 95.7 percent of the cells separated by the MACS technique expressed a C-kit+ cell marker. Additionally, it was found that 0.2 mM LC significantly increased the expression of GATA4 protein in the cardiomyogenic differentiated cells. The expression of ERK protein also suggested a significant increase of about 1.60 times in the experimental group in comparison with the control group (*P˂0.05). In brief, it was found that treating C-kit+ BM cells with LC increases cardiomyogenic differentiation by increasing the expression of GATA4. Notably, this effect can take place through MARK/ERK signaling pathway. The results of this research can be valuable in suggesting a treatment solution for cardiovascular diseases.
Bacterial Expression of TMTP1-Fused L-Asparaginase for Targeting Leukemia and Metastatic Tumor Cells
Authors: Kheirandish Mohammad Hassan , Tollabi Mohammad , Davami Fatemeh , Rahmani Behnaz , Hashemi Aval Negin Sadat , Behroozi Javad , Zarei Jaliani Hossein
Published: July 2023

L-asparaginase is recognized as a first-line anticancer drug for acute lymphoblastic leukemia (ALL); however, low-substrate specificity and exhibiting glutaminase activity cause various off-target toxicities on normal cells. In the following study, we functionalized wild-type asparaginase with the TMTP1 targeting peptide which specifically targets a variety of hematological and metastatic cancer cells. The peptide sequence was genetically added to the N-terminal end of the asparaginase using the restriction endonuclease-free cloning method. Wild-type and engineered asparaginases were expressed in E. coli and purified by Nickel affinity chromatography column. The in vitro activity of both types of enzymes was evaluated by Nessler’s method. The sequencing results showed that the TMTP1 sequence was added in the correct frame to the asparaginase. Wild-type and TMTP1-fused asparaginases were produced in a soluble state with the specific activity of 172 U/mg and 153 U/mg, respectively. The evidence from this study suggests that TMTP1-fused asparaginase could preserve its solubility and activity compared to the wild-type species and can be proposed for future research in anticancer therapies.
Rosai-Dorfman Disease With Pure and Multifocal Cutaneous Lesions: A Case Report
Authors: Chebbi Donia , Marzouk Sameh , Salah Raida Ben , Chabchoub Imen , Snoussi Mouna , Bahloul Zouhir
Published: July 2023

A 52‐year‐old woman developed progressive infiltrated purple and hyperpigmented cutaneous lesions in the face, thighs, armpits, chest, and abdomen evolving forone year. Histopathological examination showed large histiocytes exhibiting intact inflammatory cells in their cytoplasm (emperipolesis). Immunohistochemical analyses showed that the histiocyte population was positive for S100 and CD68, but negative for CD1a. Based on the clinical, histopathological, and immunohistochemical findings, we made the diagnosis of Rosai Dorfman disease (RDD). Our patient didn’t manifest any other extra-cutaneous involvement and all the biological and radiological investigations were normal. This form of pure cutaneous RDD (P-CRDD) with multifocal lesions has been rarely reported. RDD is very rare and hardly recognized in the absence of lymphadenopathy. The diagnosis of this entity involves a combination of histology and immunohistochemistry. To date, there is no standard treatment.
The New Industrial Organization: Ecosystem Competition
Authors: Lorne Frank , Razzaque Anjum
Published: July 2023

This paper characterizes a new industrial organization framework for analyzing ecosystem formation and competition by recognizing the Schumpeterian force of creative destruction. Economists’ framework of profit maximization is replaced by a Welfare Enhancing framework (WEF)as a more pragmatic and realistic characterization of reality. Consumers are not fish in the ocean waiting to be preyed upon; they have free choice and broad lifestyle choices. The supply and demand framework is still relevant even though profit maximization in the theoretical sense that it has been technically crafted by economists may not. Firms as epistemic communities are more fitting as the behavioral assumption that can be more pragmatically applied. By using graphs and examples, three types of ecosystems are discussed, each sharing the commonality of data management as a driver for its respective ecosystem. The first two types of data management, coupled with pricing, bundling, and various industrial organization conducts, help to promote the welfare-enhancing growth of their respective ecosystems in an innocuous manner. The third type has an electrifying component resembling features of “two-sided” markets that may require Antitrust regulation. The key difference between the third and the first two types of competition is that the third type could lock in data with a specific investment of productivity less than the ideal optimal, thus reducing welfare rather than enhancing welfare.
The Impact of Fiscal Policy on the Current Account Balance in the Case of Bosnia and Herzegovina
Authors: Karalić Amir
Published: July 2023

This paper aims to investigate and determine the relationship between the budget, changes in GDP, price indices, and movement of the real exchange rate on one hand, and the state of the mud balance in Bosnia and Herzegovina during the period of 2005-2019. The paper covers literature related to this field, empirical knowledge, case studies of various international types of research, and certain econometric methods. The research results indicate the presence of a negative correlation between the budget deficit, reduction in prices and the real exchange rate, and improvement of the current balance. The outcomes vary depending on whether it is in the short-term or long-term horizon.
The Golden Age of the Big Data Audit: Agile Practices and Innovations for E-Commerce, Post-Quantum Cryptography, Psychosocial Hazards, Artificial Intelligence Algorithm Audits, and Deepfakes
Authors: Sood Suresh , Kim Angela
Published: July 2023

Since the audit of the Parthenon in the 5th century, the audit has remained unchanged, focusing backward on financial statements. Global regulatory pressures are mounting for audit professionals and public accounting firms to make structural changes. In the 21st century, a new type of audit, the EPSAC value audit, is emerging, focusing on non-financial information, including operational data from company business functions and processes, and big external data, including social media. In addition, EPSAC focuses on the critical engagement areas of e-commerce, post-quantum cryptography, psychosocial hazards, artificial intelligence and machine learning, and tackling deepfakes. While a talent shortage of subject matter experts exists, auditors can use artificial intelligence knowledge bases to deliver the value audit. Such knowledge bases extend to the key EPSAC domains of cybersecurity and ESG, creating proxies for virtual team members. For example, industry 5.0, combining A.I. and IoT innovations, requires auditors to augment their skill sets with knowledge bases beyond traditional financial expertise to effectively navigate the complexities of the changing business environment, enhance the quality of audits, and provide valuable insights and assurance to stakeholders.
New Times in Performance Evaluation
Authors: Barna Zsolt
Published: July 2023

The research topic focuses on performance evaluation in business organizations with varying ownership structures. Fundamentally changed planning cycles, epidemics, war, raw material shortages, and energy crises have rewritten the everyday life and planning cycles of controlling and HR. The unified labor market and companies’ preparedness for the new situation, the constraints of project-based short planning periods, have led to exciting results in performance assessment. The questionnaire research aimed to shed light on the need for performance appraisal, the demand for it on the part of employees and employers, and the methods and time intervals that are not appropriately used, showing this for different company sizes and ownership structures.
Multi-Product Production Optimization of Maintenance Integrated into the Control Chart Under Service Level and Quality Constraints
Authors: Sahabi Abubakar Aminu , Hajej Zied , C. Nyoungue Aime
Published: July 2023

This work proposes a combined production, maintenance, and quality control for a supply chain management system. In this work, we consider a joint model production system consisting of a single machine producing multi-products connected to a multi-warehouse to satisfy changing and characterized customer demand for all the products throughout the production horizon. The work will answer some managerial questions about which product to produce and how much each is to make. Then the need for a maintenance strategy corresponding to the optimal production plan. The unreliable production system is prone to random failure, directly impacting product quality. The variance in production rate, inventory management, and utilization affects the status of the production system and its maintenance evolution. The control of the process and its quality is carried out using a multi-level statistical process control (SPC) and its tool, “control chart of average.” The goal is to create a constraint optimization model that reduces total cost while meeting changing customer requests across many warehouses and over time. We consider the impact of production rate on the production machine degradation, the increasing failure model, and maintenance methods based on the optimal parameters of the control chart.
The Cohesion Analysis of Students’ Multimodal Text Creations
Authors: Anggraeni Ika , Hidayat Didin Nuruddin , Husna Nida , Alek Alek , Halim Abdul
Published: July 2023

Examining cohesion of students’ compositions (e.g., students’ thesis writing, narratives) has been conducted by many researchers, yet cohesion of students’ multimodal text creations (a picture with captions) is still paucity. Therefore, this study aims to fill the research gap by examining the cohesion of students’ multimodal text creations using grammatical cohesive devices proposed by Halliday and Hasan (2014a) and inter-semiotic cohesive devices proposed by Liu and O’Halloran (2009). The students’ caption text analysis showed that students use three cohesive grammatical devices: references at 49%, conjunctions at 46%, and substitution at 5%. The most frequent types of them used by the students are personal references at 76%, additive conjunction at 63%, and clausal substitution at 67%. In addition, the analysis of inter-semiotic cohesive devices shows that parallel structure is hardly found in multimodal texts. Still, surprisingly, inter-semiotic polysemy is utilized by students to create co-contextualize relationships between language and images and experiential convergence. The study concluded that students in the twelfth grade of Nurul Huda Vocational High School lack using various cohesive devices. Nonetheless, they complement their caption with inter-semiotic cohesive devices embedded in the images. This study implies that the students still need more time allocation to study the subject at hand and go through the writing process as professionals do to create a better text for more elaboration and characteristics of written language with accuracy and consistency.
The Contribution of Self-Concept, Independence, and Creativity to the Literacy Competency of the Fourth-Grade Elementary School Students
Authors: Dewi I Gusti Ayu Wira Puspita
Published: July 2023

This research is quantitative with an ex-post-facto design. It aims to determine the contribution of self-concept, independence, and creativity to the literacy competence of fourth-grade elementary school students in Gugus IV, Abiansemal District. The population of this study was 131 students, while the sample was 97 students, and was determined by using the Proportional Stratified Random Sampling Technique. Data were collected by using a questionnaire and a test. All in all, the results showed: 1) there was a significant contribution of self-concept to students' literacy competence with a contribution of 51.9% and an effective contribution of 25.38%, 2) there was a significant contribution of independence to competence student literacy with a contribution of 43.5% and contribution of 23.51%, 3) there was a significant contribution of creativity to students' literacy competence with a contribution of 41.5% and contribution of 20%. 4) Simultaneously, there was a significant contribution of self-concept, independence, and creativity to students' literacy competence with a contribution of 68.9%.
Maqāṣid al-Sharī‘a as the Foundation of Islamic Moderation: Theo-Philosophical Insight against Extreme Religious Ideology
Authors: Mutawali Mutawali
Published: July 2023

The emergence of neo-Khawarij groups in the contemporary world has attracted domestic and international attention. These groups have shown a propensity for growth, as evidenced by the increasing number of terrorist attacks in the form of suicide bombings carried out in the name of Islam. Such acts of terror have led to Islam being labeled as a religion of hate, bigotry, and terrorism. Through the analysis of Maqāṣid al-sharī‘a in understanding Islamic texts, in this study, Islamic Moderation is proposed as a paradigm to reduce the penetration of radical ideology in religion. This study proposes the adoption of moderate Islam as a paradigm for countering the spread of radical ideologies within the religion. To this end, this paper begins with an overview of the references used by radical groups and the acts of terror they have committed. It then advocates for the importance of Maqāṣid al-sharī‘a in understanding Islamic texts. It offers the concept of moderate Islam as a precautionary measure for mitigating the penetration of radical ideologies.
“Feminismo é para todo mundo?”: notas sobre mulheres vítimas de violações de direitos
Authors: Rodrigues Aurea Maria Pires , Zoboli Fabio
Published: July 2023

O presente artigo objetiva cartografar o plano de afetos no encontro de uma psicóloga com corpos de mulheres violadas. Para tal problematiza as capturas do movimento feminista pautado num suposto esvaziamento político, inclusive com a própria produção da mulher enquanto sujeito de direito, uma vez que, parte-se de um conceito uno de mulher, erigido por engrenagens biopolíticas. Ao interpelar tal captura tenta abrir fendas a partir de um cartografar com as mulheres por fora da linha do “sujeito de direito do feminismo”, visualizando um caminho que pode gestar outros modos para se livrar das engrenagens biopolíticas. Conclui-se que o feminismo precisa rever alguns de seus pressupostos históricos, além disso, faz-se necessário rever algumas questões de sua luta a partir de outras epistemologias (outros modos, outros encontros, outros fazeres) a fim de pautar políticas públicas para mulheres.
SISTEM CERDAS PENDIAGNOSIS KECANDUAN INTERNET YANG MENGGUNAKAN SISTEM PAKAR RUNUT MUNDUR
Authors: Iksan Nur , Yani Achmad , Manaf Abdi , Ismail  , Panessai Ismail Yusuf
Published: July 2023

Bermula sejak COVID19 maka hampir setiap orang di seluruh dunia menggunakan internet bahkan hingga tahap yang mencemaskan yaitu kecanduan internet. Beberapa penelitian melaporkan bahwa tingkat kecanduan terhadap penggunaan jaringan internet semakin tinggi walaupun COVID19 telah reda. Remaja belum mampu memilih aktivitas sambungan internet yang bermanfaat dan mereka lebih mudah mengalami pengaruh buruk lingkungan pergaulan. Untuk mengatasi hal tersebut mereka perlu dukungan dari para psikolog sehingga dapat mencegah dan mendiagnosis dini sebelum mereka menjadi penderita kecanduan internet berat. Namun disisi lain, jumlah psikolog yang dapat membantu masih sangat terbatas terutama di kota-kota kecil. Selain itu faktor ekonomi dan keterbatasan waktu orangtua dalam mendapingi anaknya mengunjugi psikolog menjadi penghambat utama. Oleh karena itu perlu ditemukan solusi yang dapat mengatasi keterbatasan-keterbatasan dan penghambat remaja dalam mendapatkan pelayanan dari seorang psikolog. Salah satu solusi dari permasalahan tersebut adalah membangun sebuah sistem pakar yang dapat bekerja sebagai seorang psikolog. Tujuan penelitian ini adalah untuk membangun sebuah aplikasi sistem pakar untuk melakukan diagnosis kecanduan internet dengan menggunakan metode runut mundur. Tingkat kecanduan internet dikategorikan dalam rendah, sedang dan tinggi. Pengujian sistem dilakukan dengan menggunakan pengujian black box yang memungkinkan pakar memperoleh kumpulan kondisi keluaran yang akan mengerjakan seluruh keperluan fungsional program. Pengujian ini menunjukkan pemasukan data keluaran telah berjalan sebagaimana yang diharapkan.
Alain Badiou, the Communist Horizon Beyond Violence. An Exploratory Look at the 21st Century
Authors: Barria-Asenjo Nicol A. , Acuña Echagüe Willingthon , Uribe Muñoz Jamadier , Gallo Acosta Jairo , Medina Polo Simone A. , León Alberto , Kargodorian Silvia , Letelier Antonio , Ayala-Colqui Jesús
Published: July 2023

This research paper examines the work of philosopher Alain Badiou and his analysis of 20th-century violence. The author argues that the last century was marked by violence and destruction, from world wars to extermination camps and state crimes. Badiou claims that this violence stems from a passion for the real, a quest to transform existing reality and create a new world. However, this passion clashes with reality itself, creating an irreducible difference between the real and constructed reality. This difference is what allows us to understand the phenomenon of violence. The passion for the real seeks to purify it and unmask the superficiality of reality, but it can never fully achieve its goal. Furthermore, this passion for the real creates constant mistrust of semblances, leading to suspicion and persecution. The totalitarian violence of the 20th century arises from this infinite suspicion directed towards semblances. The article explores in detail the relationship between the passion for the real, violence, and the distance between the real and semblances.
Perspectiva antropológica como condición de posibilidad para la construcción del ethos universitario
Authors: Patiño Morales William Arley
Published: July 2023

El presente artículo propone una perspectiva antropológica para la construcción del ethos universitario a partir de un enfoque hermenéutico, que tiene en cuenta, primero, las reflexiones filosóficas de Theodor W. Adorno, en su texto “Educación después de Auschwitz” (1998) y, segundo, las críticas realizadas por Michel Foucault a los sistemas de poder dominantes, así como al proyecto de la Ilustración, en escritos como “¿Qué es la Ilustración?” (1994), La hermenéutica del sujeto (2011) y La verdad y las formas jurídicas (1983). Con fundamento en lo anterior, por un lado, se da cuenta de la construcción de ciertos ethos universitario –configurados, en ocasiones, por relaciones de poder, dominación y sujeción– permeados por estructuras hegemónicas inmersas en modelos socioeconómicos. Y por otro, se sugieren nuevas maneras de conformar los ethos universitarios a partir de una perspectiva antropológica contextual.
From traditional to tech-savvy: An empirical investigation of students' actual use of LMS in Saudi universities
Authors: Alquhaif Abdulsalam , Abdulrab Mohammed , Rashed Redhwan Qasem , Al-Mamary Yaser Hasan , Jazim Fawaz , Abdalraheem Shirien Gaffar , Siddiqui Malika Anwar , Abubakar Aliyu Alhaji
Published: July 2023

The primary objective of this research endeavor is to comprehensively comprehend the impact of identified research factors on students' intentions to utilize learning management systems (LMS) in Saudi Arabian universities. In order to achieve this objective, the study has incorporated two prominent motivational models, namely the DeLone and McLean Model, and the technology acceptance model (TAM). The hypothesized relationships were succinctly depicted and experimentally validated through a sample of 224 students from Saudi Arabian universities. The findings of the study reveal significant correlations among all the proposed hypotheses. The research model employed in this project demonstrates that system quality, information quality, service quality, perceived usefulness, perceived enjoyment, and perceived ease of use exert direct influence on university students' intentions to employ LMS. Moreover, the research model highlights that the intention to use LMS significantly impacts actual usage behavior. By developing an innovative and integrated model for gauging students' genuine individual intentions to use LMS, this research paper makes a valuable contribution to the existing literature.
Research on Issues and Countermeasures of Innovation Education among College Students
Authors: Xu Yali
Published: July 2023

In today’s world, innovation is increasingly becoming a key factor in national economic and scientific and technological competition, and plays an important role in measuring a country’s comprehensive national power. Youth is the future of the country and the hope of the nation, and college students are one of the most energetic and creative groups of youth. With the continuous development and change of the society, it is more and more important to cultivate the innovative thinking and practical ability of college students for the development of the country and the progress of the society. Universities are the cradle for young people to grow up and become successful, and they are committed to cultivating innovative talents, shaping the innovative spirit of college students and improving their entrepreneurial ability. College students are the backbone of the future development of the country by cultivating students’ creativity, critical thinking and problem-solving ability, they can become the innovative leaders of the future society. However, in reality, there are still some problems that need to be solved in college students’ innovation spirit, such as the interaction of multiple factors such as the education system, neglect of colleges and universities, and the lack of attention of individuals, etc. We can improve the cultivation mode, establish a long-term mechanism, create an innovative atmosphere, and pay attention to self-cultivation in order to cultivate modernized talents with the spirit of innovation and entrepreneurial ability for the construction of an innovative country.
Rural Education and the Use of Digital Technologies: A Look at the Structure and Functioning of Teaching in the Context of the Municipality of Altamira/Pará
Authors: Leonel Ronaldo dos Santos , Albuquerque Jacirene Vasconcelos de
Published: July 2023

Technological advances in the first decade of the 21st century created a social dynamic marked by technological advances that transformed everyday behavior and people's way of being in local and global contexts. Technological advances demanded that information, strategies, resources and knowledge were in people's hands, including the process of using digital technologies in rural education. Specifically, this context influenced the reflection on the use of technologies in rural education in the municipality of Altamira in Pará/Brazil. Thus, in this research, a bibliographic survey was carried out on technologies and their use in rural education, as well as a survey of data from the Department of Education on the structure and functioning of teaching in schools in rural areas. Content analysis for data processing revealed the precariousness of rural education in terms of buildings and technological infrastructure, as well as the lack of initial and continuing training of teachers with Information and Communication Technologies. The experience of Educação do Campo in Altamira-PA demonstrates the distancing from Brazilian legal requirements and scientific stimuli on the use of technologies in teaching. In addition, he emphasized the growing interest of government entities in supporting educational public policies for digital inclusion in rural education.
Exploring the Relationship between HR Practices and Employee Retention: A Study of Administrative Staff in the Tech Industry
Authors: Durra Ibrahim
Published: July 2023

This academic article investigates the relationship between HR practices and employee retention within the tech industry. The study aims to analyze how specific HR practices impact employee retention and provide insights into effective strategies for organizations. The research sample includes 338 administrative staff members from various tech companies. The study employs a quantitative approach, conducting reliability analysis and regression analysis using SPSS to analyze the collected data.
A Review on Self Healing Concrete
Authors: Singh Arushi , Kaur Taranpreet
Published: July 2023

Abstract: Self-healing concrete, also known as bacterial concrete, fills in structural flaws caused by bacterial response in the concrete after it has hardened. The manufacture of bacterial concrete and several bacterial types are addressed. The usage of technology has raised construction standards to a new, lofty level in the modern era. To create a concrete structure that is excellent, sustainable, and affordable, several sorts of procedures, methods, and materials are used. However an effective building struggles to last the length of time it is intended to due to human error, improper handling, and unskilled work. After construction, a number of issues, including weathering, cracks, leaks, and bending, etc., appear. Many corrective measures are implemented before and after the construction to address these types of issues.This review paper mainly focuses on biological self healing concrete but the chemical self healing concrete is also mentioned
The Future of E-commerce: Trends, Challenges, and Opportunities
Authors: Verma Sarika , Dixit Dr. Gireesh Kumar
Published: July 2023

Abstract: This research paper delves into the evolution of e-commerce and explores its future prospects. Over the past few decades, e-commerce has witnessed exponential growth, revolutionizing business operations and consumer shopping habits. With advancements in technology and changing consumer preferences, the e-commerce industry is poised for further expansion. This paper examines the key trends, challenges, and opportunities that are likely to shape the future of e-commerce. Additionally, the paper emphasizes the use of plagiarism detection tools to ensure the originality of its content
I-Detox
Authors: Shejy Prof. Geocey , Salvi Varun , Sawant Athurva , Chhabria Muskan
Published: July 2023

Abstract: Internet addiction refers to excessive internet use that interferes with daily life. Due to its negative impact on college students’ study and life, discovering students’ internet addiction tendencies and making correct guidance for them timely is necessary. In this system, we provide an approach to estimatinga person’s internet addiction levels using their behavior data on the system. In detail, we consider a person’s addiction to the internet as a hidden variable that affects students’ daily time online together with other behavior. By predicting a person’s daily time online, we will find a person’s internet addiction levels. Finally, extensive experiments are conducted on a real- world dataset. The experimental results show the effectivenessof our method, and it is also consistent with some psychological findings. “I-detox” aims to provide real-time analysis of the exact number of websites visited by the user, giving them the freedom to foresee the probable results given the lack of schedule one followswhile browsing the internet. Therefore, this gives a standardized analysis of the web history of the user also inclining the number of times a user visits a particular website. Our solution considers the suitability of terming the user as an addict or not based onthe analysis provided upfront.
PREVALENCE OF INTESTINAL PROTOZOA, HELMINTHES, AND COCCIDIAN INFECTIONS AMONG PRIMARY SCHOOL CHILDREN IN THALA’A DISTRICT AT AMRAN GOVERNORATE, YEMEN
Authors: AL-Mekhlafi Abdulsalam M. , Al-Moyed Khaled Abdulkareem , Al-Shamahy Hassan Abdulwahab , Al-Haddad Ahmed Mohamed , Al-Ankoshy Azhar Azher Mohammed , Al-Shamahi Emad Hassan
Published: July 2023

Background and objectives:  The prevalence of intestinal parasite infection, which can range between 18% and 90%, is one of the most frequently reported diseases in Yemen and poses a serious health issue for schoolchildren. In Thala’a District, Amran Governorate, Yemen, the study's main goal was to ascertain the prevalence of intestinal parasite infection among primary school students.
Subjects and methods: A cross-sectional survey was conducted from January to April 2022 among 400 schoolchildren, in the age groups 7-12 years. All the children were residents of the city of Thala’a. A pre-tested structured questionnaire was used to collect data. Stool samples were examined for intestinal parasites according to standard laboratory methods.
Results: The children's ages ranged from 7 to 12 years, with a mean±SD of 9.52 ± 2.9 years. The results showed that 136/400 (34%) of the tested children were positive for intestinal parasite infection with a higher prevalence of specific intestinal worms (50.4%) than protozoa (33.3%) and coccidian infection (16.3%). The rate of infection alone was also higher than that of multiple parasitic infections (19.3% vs. 14.8%). The highest number of intestinal parasites was 50/400 (12.5%) for Ascaris lumbricoides, and 49/400 (12.25%) for Entameba histolytica followed by 9.8% for Giardia lamblia, 11.5% for Entrobius vermicularis, 6.5% for Cryptosporidium species, 6.5% for Hymenolepis nana, 2% for Schistosoma mansoni, and 0.8% for Trichuris trichiura. Considering the associated factors, boys had a higher infection rate than girls (50% vs. 24.2%) with an OR of 2.6, CI =1.7–3.9 (p < 0.001). A higher rate was also recorded in older children (41%) with an odds ratio of 1.6 (p=0.03).
Conclusion: There is a high prevalence of intestinal parasites among school children in Thala’a city, and various control measures are required to control and prevent intestinal parasites among school children.
                        
Peer Review History:
Received: 3 March 2023; Revised: 22 April; Accepted: 27 June 2023, Available online: 15 July 2023
Academic Editor: Dr. Asia Selman Abdullah, Pharmacy institute, University of Basrah, Iraq, asia_abdullah65@yahoo.com
Received file:                             Reviewer's Comments:
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Rola Jadallah, Arab American University, Palestine, rola@aauj.edu
Dr. Tamer Elhabibi, Suez Canal University, Egypt, tamer_hassan@pharm.suez.edu.eg
Dr. Sheikh Abdul Khaliq, Department of Pharmacy Practice, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan, drwadhsheikh1974@gmail.com
EFFICACY OF DRACAENA CINNABARI AS TOOTH WHITENING NATURAL PRODUCT: A SPECTROPHOTOMETRIC ANALYSIS
Authors: Elaiwa Wedad Omar Ali , Al-Shami Ibrahim Zaid , AL-Hamzi Mohsen , Al-kholani Abdul Wahab , Al-Ghorafi Mokhtar Abd Hafiz Abd Alhamid , Othman Nagwa
Published: July 2023

Objective: The aim of this study was to determine the efficacy of a homemade tooth-whitening recipe using Dracaena cinnabari (DC) resin, which is traditionally used for tooth decay treatment and cleaning in Soqatra. The study investigated the antioxidant activity of the resin extracts in methanol as tooth-whitening natural product.
Materials and Methods: A total of 40 bovine teeth with initial color B2 were selected and divided into four groups. One group was kept as a negative control, while the other three were stained with Yemeni coffee solution for one week. The first group was treated with 10% carbamide peroxide (CP) home bleaching, the second group was treated with 10% DC gel with rubbing movement (DC Ru), and the third group was treated with 10% DC gel without rubbing (DC) for 6 hours daily for 14 days. Color measurements were taken at different time points using a spectrophotometer device.
Results: All experimental gels resulted in greater color change compared to the negative control, with DC Ru showing the greatest ΔE* value (p<.001) compared to the DC group (p<.006) and the CP group (p<.001). The second reading of stabilization of all gels resulted with resembled ΔE* values to the first reading of stabilization. 
Conclusion: The study suggests that the experimental gels containing phenolic content with strong antioxidant effects may reserve significant clinical potential as active agents for tooth-whitening without using HP/CP. Further studies are needed to measure the effect on surface roughness and color stability.
                          
Peer Review History:
Received: 9 March 2023; Revised: 23 April; Accepted: 25 June 2023, Available online: 15 July 2023
Academic Editor: Prof. Dr. Gorkem Dulger, Duzce University, Turkey, gorkemdulger@yandex.com
Received file:                             Reviewer's Comments:
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my
Prof. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com
DEVELOPMENT AND CHARACTERIZATION OF PALONOSETRON HYDROCHLORIDE JELLIES
Authors: Islam Md. Shahidul , Mojumder Tanjum Jahan , Nawrin Farjana
Published: July 2023

Aim and objective: Dysphagia is one of the most common diseases mainly in geriatric and podiatric populations. As swallowing is the main difficulty in dysphagic patients, in that situation medicated jelly preparations are the best alternative to conventional doses forms (tablets and capsule doses form). This research article is aimed at the formulation and evaluation of Palonosetron hydrochloride oral jelly to avoid swallowing related issues in paediatric and geriatric patients and to improve its bioavailability.
Methods: Two methods i.e., congealing and heating were chosen to prepare sucrose-based jellies. All prepared formulation were evaluated on different parameters like physical appearance, drug content, pH and dissolution study, stability study etc.
Results: All formulation was found free from any type of gritty particles. Out of all formulations MJ1 was found best formulation on the basis of drug release profile i.e., 79.22% within 30 mins. Accelerated stability studies also confirmed that MJ1 and MJ2 are the best formulations.
Conclusion: This study concludes that Palonosetron hydrochloride can be delivered successfully by the means of jellies to avoid first pass metabolism.
                        
Peer Review History:
Received:  4 March 2023; Revised:  26 April; Accepted: 20 June 2023, Available online: 15 July 2023
Academic Editor: Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, olorunsolaeo@yahoo.com
Received file:                             Reviewer's Comments:
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Rola Jadallah, Arab American University, Palestine, rola@aauj.edu
Dr. Ogbonna B. Onyebuchi, Nnamdi Azikiwe University, Awka,  Nigeria, summitpharm@yahoo.com
EVALUATION OF METRONIDAZOLE TABLETS FORMULATED WITH DIFFERENT DISINTEGRANTS USING MOISTURE ACTIVATED DRY GRANULATION
Authors: Andrew Ezegbe Chekwube , Grace Ezegbe Amarachi , Salome Chime Amarachi , Elochukwu Ugwu Calister , Izuchukwu Boniface Christian , Ejiofor Ugwuoke Kenneth , Lorrita Chukwuemeka Chizoba , Godswill Onunkwo
Published: July 2023

Introduction:  Metronidazole is a synthetic oral nitroimidazole antibiotic used in the treatment of infections caused by anaerobic bacteria and protozoa. It also has amebicidal and antiprotozoal properties.
Aim: The purpose of the study was to formulate and evaluate metronidazole tablets formulated with polymers (PVP and PEG) and maize starch as disintegrant using moisture activated dry granulation (MADG).
Method: Twenty-four (24) batches of metronidazole granules and tablets were prepared by moisture activated dry granulation.  Metronidazole (200 mg), lactose and gelatin (1, 2, 4, and 8 %) were mixed, followed by continuous mixing. Prior to compression, micro-crystalline cellulose, disintegrants and magnesium stearate were added. The dried granules were passed via 1.0 mm sieve after which they were labelled and stored in an air tight container. All other batches were also similarly prepared.
Result: The result showed that the mean weight of the tablets ranged from 0.33±0.01 to 0.35±0.04 g. Tablet hardness ranged from 5.00±0.85 to 6.36±1.43. The results showed that batch 11 tablets had higher crushing strength than batch 24 with a significant difference. Table 2 shows the hardness test results and clearly indicates that the results of all the samples significantly differ from each other (p<0.05). The tablet friability test ranged from 0.21±0.17 for batch 24 and 0.60±0.16 for batch 11.  The formulated tablets showed average disintegration time ranges from 0.52±0.01 to 14.03±0.03. According to USP, the disintegration time must be in the range of 15 min for uncoated tablets, and 30 mins for film coated tablets.
Conclusion: The study established that polyethylene glycol and polyvinyl pyrrolidone polymers had better dissolution profile than maize starch which has the best disintegration properties.
                        
Peer Review History:
Received: 4 March 2023; Revised: 26 April; Accepted: 20 June 2023, Available online: 15 July 2023
Academic Editor: Dr. Jennifer Audu-Peter, University of Jos, Nigeria, drambia44@gmail.com
Received file:                             Reviewer's Comments:
Average Peer review marks at initial stage: 5.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Julie Ann S. Ng, Blk 18 Lot 6 Grandville 3 Subdivision Mansilingan, Bacolod City, Philippines.  julieann_ng@yahoo.com
Dr. Essam Mohamed Eissa, Beni-Suef – 32 Tahrir St, Egypt, dressamceutics@yahoo.com
DEVELOPMENT AND EVALUATION OF MICROEMULSION FORMULATIONS OF BIFONAZOLE
Authors: Islam Md. Shahidul , Mojumder Tanjum Jahan , Nawrin Farjana
Published: July 2023

Aim and objective: The purpose of this study was to develop microemulsion formulations for topical delivery of bifonazole with an objective to increase the solubility of the drug.
Methods: Total 5 microemulsion formulations were developed using water titration method. Capmul Pg-12 (oil), Tween-80: (surfactant) and Propylene glycol (co-surfactant) were used in different ratio based on the solubility and emulsification efficiency. Prepared formulations were evaluated on different parameters like transmittance (%), pH, refractive index, viscosity, drug content, solubility, and in-vitro release study Franz diffusion cell. Ternary phase diagram was prepared using oil (Capmul Pg-12), surfactant (Tween 80), co-surfactant (Propylene glycol) in different ratio
Results: The % transmission was found to be in the range of 98.47±0.09 to 99.2±0.08%, the pH value was found to be in the range of 3.34±0.08 to 4.02±0.09, refractive index in the range of 1.3418±0.016 to 1.3818±0.004, drug content was found to be in the range of 98.47± 0.08 to 99.62±0.02 %, viscosity was found to be in the range of 65.23±2.1 to 71.56±5.77%.  It was seen that after 4 hours of diffusion, the drug released from the formulation ME5 faster and more than that of the other ratios i.e., 91.2±0.06%. It was observed that drug release was governed by the diffusion process.
Conclusion: On the basis of different evaluation parameters microemulsion formulations of batch ME5 were found to be the best. Present study concludes successful delivery of Bifonazole by the means of microemulsion formulations
                       
Peer Review History:
Received: 4 March 2023; Revised: 26 April; Accepted: 20 June 2023, Available online: 15 July 2023
Academic Editor: Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com
Received file:                             Reviewer's Comments:
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Rola Jadallah, Arab American University, Palestine, rola@aauj.edu
Dr. Taiwo O Elufioye, University of Ibadan, Nigeria, toonitaiwo@yahoo.com
REVIEW OF ISLAMIC LAW ON THE IMPLEMENTATION OF PARKING LEVY COLLECTION IN PALOPO CITY
Authors: ARIF FIRMAN MUHAMMAD , MUSTAM MUSTAM
Published: July 2023

In a family sometimes painful actions arise from involuntary causes (not intentionally), not on the wishes of the husband, such as because the husband is poor or poor so he does not have a living to fulfill his wife's rights in the form of food, clothing and home at a certain time, which makes the wife ask to part with her husband through the divorce (fasakh) path. Regarding the problem of the wife asking for fasakh This thesis discusses the Islamic Legal Review of the Implementation of Parking Levy Collection in the City of Palopo. The data collection method is carried out through observation and interviews with a descriptive-qualitative approach. The results showed that in the implementation of the parking levy collection in Palopo City, there are still parking attendants who impose their own rules such as requests for tariffs exceeding the provisions; and there are still objects and parking attendants that were untouched by the Palopo City Transportation Department. This is if viewed from the perspective of Islamic law there are pillars or conditions in the wadi'ah contract (agreement) that are not fulfilled, namely the ijab qabul between the parking attendant and the vehicle owner, as well as the existence of illegal parking attendants who collect parking funds/money for the parking attendant's personal self and do not contribute to the Palopo City Area Original Income. Therefore, in order to minimize the presence of illegal parking attendants and official parking attendants who do not comply with the provisions, the Palopo City Transportation Office as the Holder of the levy for parking services on public roadsides in Palopo City to strive to carry out guidance and supervision of partner objects and parking agents and potential parking objects that have not been recorded by giving verbal and written feedback, provide an understanding of the duties and responsibilities of parking attendants and legalize objects and parking attendants that are not yet the objects of government- assisted parking.
PROBLEMATICS OF SETTLEMENT OF INHERITANCE RIGHTS OF DAUGHTER WITH SIBLINGS IN THE MAHKAMAH SYAR’IYAH BANDA ACEH AND ACEH
Authors: Amri Aulil
Published: July 2023

This research discusses the Polarization of Judges' Decisions in the Settlement of Sibling Inheritance Rights (Case Study of Decision Number: 193/Pdt.G/2020/MS.Bna AND 21/Pdt.G/2021/MS.Aceh). The formulation of the problem studied is: 1. Why is there a disparity in the judge's decision regarding the position of relatives as heirs in an inheritance dispute at the Religious Court in decision number: 193/Pdt.G/2020/MS.Bna vs. 21/Pdt.G/2021/ MS. Aceh? 2. Has the judge's decision in resolving the dispute over the determination of heirs protected the rights of heirs in accordance with faraidh? This research is normative and practical juridical research, namely library research supported by results in the field in the form of interviews with related functional officials of the Banda Aceh Syar'iyah Court and Aceh Syar'iyah Court. This study concludes that: 1. The disparity in the decisions of the Banda Aceh Syar'iyah Court and the Aceh Syar'iyah Court occurred due to an understanding of the Jumhur Ulama's opinion which stated that a daughter cannot be hindered by a daughter in receiving an inheritance. Jumhur Ulama's definition of "kalalah" is the death of someone who does not have a father or son. This is in line with jurisprudence and the opinion of Ibn 'Abbas, which stipulates that girls can wear the hijab to inherit, but girls cannot wear the hijab inherited from their brothers. 2. The judge's decision at the Banda Aceh Syar'iyah Court in resolving the dispute over the determination of heirs has protected the rights of heirs in accordance with faraidh. This is because the opinion of the jumhur of scholars and the opinion of Ibn 'Abbas are in line with the opinion of the panel of judges. Then the daughter in this case is an adult and has a steady job and income, which is different from the case in jurisprudence.