bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-World Evidence Demonstrates an Appropriate Atrial Fibrillation Population for Hybrid Convergent Approach versus Stand-Alone Cryoballoon Ablation: A Long-Term Safety and Efficacy Study
Authors: Lorenzo Christian , Ortiz-Gonzalez Yahaira , Hill Dustin , Kinaga Jennifer , Filart Lauren , Bello David , Duran Aurelio , Bott Jeffery , Filart Roland
Published: June 2023

Introduction: A hybrid convergent approach (endocardial and
epicardial ablation) demonstrated superior effectiveness in a recent
randomized study for long-standing persistent atrial fibrillation
(LSPAF). Yet, there is a lack of real-world, long-term evidence as to
which patients are best candidates for a hybrid convergent approach
compared to standard endocardial cryoballoon pulmonary vein isolation
(CB PVI). Methods and Results: This single-center,
retrospective analysis spanning from 2010 to 2015 compared two
distinctly different atrial fibrillation (AF) cohorts; one treated with
stand-alone cryoablation and one treated with a hybrid convergent
approach. Baseline characteristics described candidates for each
approach. The following criteria were utilized to determine CB PVI
candidacy: 1) paroxysmal AF (PAF) with failed class I/III antiarrhythmic
drug (AAD) or 2) persistent/LSPAF with failed class I/III AAD unwilling
to undergo hybrid procedure. Selection criteria for the hybrid procedure
included: 1) PAF refractory to both class I/III AAD and prior CB PVI or
2) persistent/LSPAF with failed class I/III AAD agreeable to hybrid
procedure. Prior sternotomy was excluded. Serial electrocardiograms and
continuous monitoring evaluated primary efficacy outcome of
time-to-first recurrence of atrial arrhythmia after a 90-day blanking
period. Secondary outcomes were procedure-related complications and AAD
use (at discharge, 12, and 36 months). Kaplan-Meier methods evaluated
arrhythmia recurrence. Of 276 patients, 197 (64.2 ± 10.6 years old;
66.5% male; 74.1% PAF; 18.3% persistent AF; 1.0% LSPAF; 6.6%
undetermined) underwent CB PVI and 79 (61.4 ± 8.1 years old; 83.5%
male; 41.8% PAF; 45.5% persistent AF; 12.7% LSPAF) underwent hybrid
procedure. Arrhythmia freedom through 36 months was 55.2% for CB PVI
and 50.4% for hybrid (p =0.32). Class I AAD utilization at discharge
occurred in 38 (19.3%) patients in the CB PVI group and 5 (6.3%)
patients in the hybrid group (p=0.01). CB PVI class I AAD utilization at
12 months occurred in 14 (9.0) patients versus 0 patients for hybrid
convergent (p=0.004). Patients with one or more adverse event were as
follows: two (1.0%) in the CB PVI group (both transient phrenic nerve
palsy) and three (3.7%) in the hybrid group (two with significant
bleeding and one with wound infection) (p=0.14). Conclusion:
This study demonstrated that patients with more complex forms of AF (PAF
refractory to both AAD and index endocardial ablation or
persistent/LSPAF) could be well managed with a convergent approach.
Moreover, outcomes match safety and efficacy thresholds achieved by
patients with an early, less complex AF etiology treated by CB PVI
alone.
Effect of Discrete Trial Teaching on the Achievement of Short-Term Objectives of Individualized Educational Program for Elementary School Students with Autism Spectrum Disorder
Authors: Han Sangkyu , Moonbong Yang Daniel
Published: June 2023

This study has the purpose to find out the effect of the Discrete Trial Teaching executed during school typical curricular sessions among lower graders of elementary special school program for Autism spectrum disorder on both the achievement and progress of short-term objectives of Individualized Educational Plan of students with autism spectrum disorder and its maintenance. The subjects of the study consisted of 18 lower elementary school graders of the aforementioned school(6 1st graders, 6 2nd graders, and 6 3rd graders). Each program for Discrete Trial Teaching contained 8 Short-Term Objectives (STO’s) and, after the analysis of the rate of Semester achievement to 144 STO’s, the rate of Progress turned out to be 97.91%. The conclusion of the study is as follows: First, the program utilizing Discrete Trial Teaching is effective to the achivement and progress of short-term objectives(STO’s) for each student. Second, the program utilizing Discrete Trial Teaching is effective to the maintenance of short-term objectives(STO’s) for each student. Based on this conclusion of the study, discussions and suggestions were presented related with antecedent studies.
A Review of Experimental Research on Self-injurious Behavior for Students with Disabilities
Authors: Yi Seong-yong. Y.
Published: June 2023

Self-injurious behavior(SIB) in students with disabilities is a severe behavioral disorder that has significant social and medical consequences. The purpose of this study was to review the research literature of SIB for students with disabilities and to provide information and suggestions on reducing SIB for future research and practices at schools. A systematic search of the literature from 1996 to 2013 revealed 17 experimental studies published in major special education journals within South Korea. This study analyzed the 17 selected studies in terms of 8 analytical variables: participants, research settings, experimental design, target skills, training program and strategies, results(ie. effects), effects size, qualitative indicators. The findings of the study were as follows: most of the participants were elementary school students of children with ASD. They had severe or profound disabilities. Most of the interventions used applied behavior analysis and positive behavioral supports. Intervention, maintenance and generalization revealed large effects(M PND > 90%). The findings of this study were described in detail on the 8 analytical variables. These findings provide implications for future research and practice to reduce SIB in students with disabilities.
Food Selectivity in Children with Autism Spectrum Disorders: A Review on Intervention Studies Based on Behavioral Methods
Authors: Kim Soo Youn , Chung Kyong-Mee
Published: June 2023

Children with ASD(Autism Spectrum Disorder) often report various feeding problems and food selectivity is one of the most frequently reported problematic eating behaviors. Applied Behavior Analysis(ABA) is the Evidence-Based Treatment(EBT) related to feeding problems for children with ASD and numbers of studies have proved treatments based on ABA to be effective. However there are almost no researches done in Korea and so analyzing previous researches done abroad would become a guideline for future studies and treatment cases in clinical settings. The purpose of this study is to review recent studies about treating food selectivity shown by children with ASD and analyze the difference according to various aspects related with the treatment and the subject of the intervention. Considering the results, It is expected for Korean researchers and clinical practitioners to select the most effective treatment programs and make progress in the field of research in feeding problems with ASD.
Study of the Relationship between Structural Elements of Self-Determination Behavior and Character Strengths of Positive Psychology
Authors: Kim Gab-Sang
Published: June 2023

The purpose of this study is to investigate the components of self-determination behavior and characteristics of character strengths of positive psychology, and to explore the relationship between the components of self-determination behavior and the variables of character strength of positive psychology. For this purpose, from 2006 to the present, researcher collected the literature on the components of self-determination behavior and character strengths of positive psychology, and analyzed based on the research design, characteristics of the subject, intervention strategy, research results, the components of self-determination behavior, and character strengths. As a result of the analysis, positive psychological character strengths which are related to the components of self-determination behavior were found by self-regulation, social intelligence, creativity, and explored the components of self-determination behavior. Based on these results, researcher discussed the relationship between the components of self-determination behavior and characteristics of character strengths of positive psychology
Study on Effect of Power Card Strategy on the Problem Behaviors of Intercepting Words, Inappropriate Postures, Repetitive & Meaningless Writing during the Class of a Preschooler with Autistic Spectrum Disorder
Authors: Yang Mi , Lee Byoung In
Published: June 2023

The purpose of this study was to investigate the effect of the power card strategy on the problem behaviors of autistic children. For this purpose, one child with autism disorder who is financially supported by a public kindergarten A kindergarten located in G district, Seoul city was selected as a child and a script and a power card for intervention were produced according to the guidelines of the power card production. The research design used a multiple baseline across behavioral design. Data collection was performed using the partial interval recording method for 10 minutes every session during the entire 30 minute class. The results of the study are as follows. First, the problem of word interception problem during the class of children with autistic disorder was significantly reduced through the power card strategy. Second, inadequate posture problem behaviors during the class of autistic children significantly decreased through the power card strategy. Third, the repetitive and meaningless writing problem behaviors during the class of autistic children decreased significantly by the power card strategy. The results of this study showed that the power card strategy had a positive effect on reducing the problem behaviors of the autistic children and it was effective in reducing the problem behaviors of children with autism. In addition, the power card strategy can be expected to have effects on behavioral interventions with minimum cost and time, and it is possible to take the power card at any time when the child needs it, so internal procedures for positive action are internalized, This is a strategy that allows us to make adjustments.
The Effects of Backward Chaining and Most-To-Least Prompting on Daily Living Skills of Children with Developmental Disabilities
Authors: Kang Youngmo , Yang Moonbong
Published: June 2023

The purpose of this study was to investigate the effects of backward chaining and most-to-least prompting on the performance of daily living skills of children with developmental disabilities. Two second-grade students from the special middle school participated in this study. Daily living skills, organizing one's bag, shoes, and jacket when the students arrive at the school in the morning, was selected as the dependent variable. The backward chaining and the most-to-least prompting provided as interventions were selected as the independent variables. For observation and measurement, the change in the performance rate was examined after analyzing daily living skills in individual 6-10 steps for each child. In this case, the performance rate was calculated as a percentage by dividing the number of task analysis steps performed by the child by the total number of task analysis steps. Using a multiple probe baseline design across behavior, the data of baseline, intervention, and maintenance phase were collected and functional relation was verified. The result of visual analysis revealed that the daily living skills of children with developmental disabilities have improved effectively by the backward chaining and the most-to-least prompting, and these intervention effects were maintained even after a period of time. Discussions, limitations, and suggestions regarding the overall study were described.
자기점검 도구로서의 개별화행동평정척도도구를 사용한 학급행동의 개선
Authors: Martinez Dominique , Blair Kwang-Sun Cho , Novotny Marissa
Published: June 2023

교실 환경에서 자기 점검에 대한 연구는 학생 행동의 개선에 효과가 있음을 보여주고 있다. 자기점검 중재를 실행하는데 있어 행동 평가 척도는 교사가 학생의 진전 상황을 점검하거나 학생이 자기 점검을 하는 도구로 사용될 수 있다. 본 연구는 학교 차원의 긍정적 행동 중재 및 지원 프로그램을 실행하고 있는, 저소득층 학생들이 주로 교육을 받고 있는 미국의 한 공립 초등학교에서 실행 한 것이다. 2학년 학생 3명을 대상으로 자기점검 도구로 개별화행동평가척도도구(IBRST)를 사용한 것이 학생들의 교실행동에 어떤 변화를 주는지 중다기초선 설계를 사용하여 그 효과를 검증해 본 연구이다. 연구결과, IBRST를 사용한 자기점검은 수업시간 중 성공적으로 대상 학생 모두의 방해행동을 감소시키고 참여행동을 증가시킨 것으로 나타났다. 또한, 용암법을 적용하여 중재를 순차적으로 제거해가는 기간에 대상 학생 모두의 개선된 행동은 유지되었고 2명 학생의 경우 중재를 중단한 후, 1주후 후속 관찰에서 변화된 행동이 유지되고 있는 것을 보여주었다.교사와 학생 모두 IBRST를 사용한 자기점검 중재 절차와 결과에 대해 높은 수준의 만족도를 보여주었다.
Hours and costs of formal and informal care following Traumatic Brain Injury and Spinal Cord Injury sustained through Motor Vehicle Accidents: A Cross-sectional Study
Authors: Gordon Robert , Simpson Grahame K. , Paasila Josephine M.
Published: June 2023

Objectives: To explore the weekly utilization of formal and informal care, and to calculate and compare the costs associated with these types of care after traumatic brain injury or spinal cord injury sustained through a motor vehicle accident in Australia.Design: Cross-sectional, quantitative design.Subjects: A total of 81 people with traumatic brain injury and 30 people with spinal cord injury from 3 rehabilitation units in New South Wales, Australia.Methods: Data were collected using questionnaires administered through semi-structured interviews, and analysed using a series of Kruskal–Wallis tests.Results: Spinal cord injury (tetraplegia/ paraplegia) was significantly more expensive for both formal and informal care compared with traumatic brain injury. The costs of formal care were significantly greater for those in the traumatic brain injury group who had a more severe injury (post-traumatic amnesia > 90 days) compared with the other traumatic brain injury groups (post-traumatic amnesia 7–28 days, 29–90 days). The costs of informal care were significantly higher for both traumatic brain injury and spinal cord injury compared with the costs of formal care.Conclusion: This study highlights the complementary role of formal and informal care in supporting people with traumatic brain injury or spinal cord injury, particularly highlighting the significant role of informal care, which needs to be more explicitly acknowledged in policy and planning processes.
LAY ABSTRACTThis study explored the weekly utilization and annual costs of formal (paid support) and informal care (unpaid support) for 81 individuals with traumatic brain injury and 30 with spinal cord injury, sustained in motor vehicle accidents in Australia. Researchers conducted interviews with study participants, who were active clients of 3 separate rehabilitation units in New South Wales (NSW), Australia. Utilization of care differed across and within groups; however, the results showed significantly higher costs for spinal cord injury than for traumatic brain injury. Those with more severe traumatic brain injuries also had significantly higher costs. Finally, informal care was utilized significantly more than formal care services and contributed towards a greater annual “cost”. Overall, these results demonstrate the significant role that informal care has following traumatic brain injury or spinal cord injury. This study highlights the overall importance and value of informal care being recognized more in policy and planning processes.
The Kitab mujarrabat al-khawass of Abuleli (c.1060-1131)
Authors: Arvide Cambra Luisa Maria
Published: June 2023

Abū l- ‘Alā’ Zuhr, known as Abuleli (c.1060-1131), is one of the most important physicians from Al-Andalus and wrote on pharmacology and medicine. He is the main author on popular scientific knowledge in the Middle Ages together with AlMajūsī (d.994) in East. Among his works, we find the treatise entitled in Arabic Kitāb mujarrabāt al-khawāṣṣ (Book of the experience facts) that contains interesting descriptions on the healing qualities and the medical characteristics of diverse minerals, plants and animals as well as other incredible attributes that are included in the framework of folk medicine. This paper is an approach to the study of this book and adds the English translation of some of its texts taken from the 520th Arabic manuscript at the Bodleian Library in Oxford, UK.
Evaluation of the Use of SGLT2 Inhibitor in the Symptomatic Improvement of Patients with Chagas Cardiomyopathy
Authors: Salles Figueiredo Clara
Published: June 2023

Chagas cardiomyopathy (CC) remains a serious disease with a poor prognosis in Latin America, and its treatment is based on the use of drugs commonly prescribed for heart failure (HF). Sodium glucose cotransporter-2 inhibitors (SGTL2i) improved cardiovascular mortality and HF hospitalization in several trials. As a result of growing body evidence in HF from different etiologies, it is reasonable to consider its potential benefits in CC. This study describes the impact on quality of life (QoL), using the New York Heart Association (NYHA) classification, the KCCQ and the 6MWT, in symptomatic patients with CC after the use of Dapagliflozin, an SGTL2i inhibitor, for a 12-week period. In this case of series of patients with Chagas Heart Disease, the use of dapagliflozin was associated with significant improvement in symptoms assessed by the NYHA classification and KCCQ scores, however there was not an improvement in performance on the 6MWT.
Regulation of Energy Homeostasis in Cancer
Authors: Tetik Sermin
Published: June 2023

The disease called cancer is actually the abnormal uncontrolled growth and proliferation of cells in our body by mutation. Reprogramming of metabolism in order to carry on the growth and proliferation of cancer cells is one of the most important changes seen in cancer cells. Altered metabolism is among the main causes of cancer. Cancer cells consume a lot of energy therefore it starts seeking for alternative fuels and their metabolisms vary compared to normal cells. The most important of these differences is aerobic glycolysis known as the ‘Warburg effect’. AMP-activated protein kinase (AMPK) is an energy sensor of our body and keeps it in a certain order. AMPK provides the balance between catabolism and anabolism. Another issue that needs to be mentioned in cancer metabolism is the p53 gene. The p53 gene is the most frequently mutated gene in cancer cells and is responsible for cell cycle and death. It is our circadian system that regulates metabolism in a 24-hour rhythm. In daily nutrition, the time of feeding is as important as the amount of energy intake. Our circadian system regulates glucose, lipid and energy metabolism, glucose homeostasis, as well as hunger and satiety cycles. Changes in metabolism occur when the order of the circadian system has been left. This situation causes the metabolic diseases. Circadian disruption has a carcinogenic effect on our body. We should try to protect our health by maintaining our circadian system. In this review we discuss the regulation of energy homeostasis with glucose, alternative ways, and circadian rhythm disruption in cancer cells.
The Effect of RBD-Based Vaccines on Covid-19 XBB 1.5 Subvariant
Authors: Norizadeh Mostafa
Published: June 2023

COVID-19 (Coronavirus disease 2019 or severe acute respiratory syndrome coronavirus 2) is a transmissible illness affected by a virus of the Coronaviridae family. Omicron is one of the COVID-19 variants of SARS-CoV-2 that firstly informed from Botswana B.1.1.529 was the original subvariant of omicron and then numerous sub-variants of Omicron have appeared comprising: BA.1, BA.2, BA.3, BA.4, and BA.5, BQ.1 and BQ.1.1, XBB.1, and XBB 1.5. The aim of this in silico research is to investigate the effect of monovalent (monovalent) vaccines on the XBB.1.5 variant. In this in silico study the sequence of spike protein obtained from NCBI and then the mutations of XBB 1.5 were add to obtained sequence. Since most of the currently used vaccines belong to the RBD region, in this study the RBD mutations were analyzed. All B cell and T cell epitopes of original strain (Wuhan) recorded and the epitopes that changed via mutation (XBB 1.5) were removed. The original virus has 10 B-cell epitopes in the RBD region. 5 of these epitopes were not mutated (unchanged. Besides the B cells epitopes, 45 alleles of T cell epitopes were also unchanged. The result of this study informed that the monovalent vaccine can produce humoral and especially cellular immunity and the vaccines help protect against severe illness, hospitalization, and death. The mutations will certainly reduce the effectiveness of monovalent vaccine, so the use of bivalent vaccines is recommended. Some countries do not have bivalent vaccines; these countries can still use monovalent vaccines.
Assessment of Self-Medication and Disease Awareness about Migraine in Local Community of Multan, Pakistan
Authors: Shahzad Qasim
Published: June 2023

Background: Self-Medication and Poor disease awareness of Migraine is the furthermost public well-being concern in many countries, as well as in Pakistan. Thus considering the current epidemiological evidence about that issue, this study aimed to determine the systematic analysis of Self-medication and disease awareness about Migraine in Multan’s Community. Methods: A cross-sectional study was conducted in Multan’s Community of about 306 participants. Among them 130 were males and 176 were Females. Statistical analysis was done by using IBM SPSS statistics version 23. And different tests (Pearson’s Chi-Square test, Independent sample t-test as well as Mann-Whitney U test) are being applied. Results: The whole target (n=306) participated in our study. Out of 306 participants, females had the greatest practice of Self-medication (54.90%) than males (42.15%). Also, females have a greater ratio (28.43%) than males (19.93%) for seeking not any help from doctors for migraine’s problems. The Paracetamol drug was being the most self-medicated drug for females (13.07%) than males (12.74%). Conclusion: The results showed a higher prevalence of Self-medication in the Multan community. Findings suggest that there should be educational seminars and efficient Migraine care management plans should be planned for doctors for proper disease awareness and to reduce to self-medication burden for patients.
Determinants of Contraceptive Utilization among Married Women
Authors: Shahzad Qasim
Published: June 2023

We studied the literature available on contraceptive methods to check their prevalence and efficiency. Contraceptive methods influence the fertility reduction. Commonly used contraceptive methods include intrauterine devices, pills, tubectomy and condoms. People of backward areas use abortion as contraceptive method. Most of the people do not have any knowledge about the use of contraceptive methods. Communication about family planning and exposure to mass media play important role in knowing the contraceptive methods and their uses. So, we recommend that government should pay attention to family planning services and providing more professional clinics.
Evaluation of Anti-inflammatory Activity of Clerodendrum wallichii (Merr.) Leaves
Authors: Singh Bora Kundan
Published: June 2023

Clerodendrum wallichii Merr. (Family: Verbenaceae) commonly known as Sampulis is native to Southern Asia from the Himalayas to Southern China, the Nicobar Islands and Northeast into Pakistan. In India, it is mainly found in Sikkim, Tripura, Mizoram, Meghalaya, Assam, Maharashtra and Uttarakhand regions. It is widely used for various ailments in the traditional systems of medicines; most importantly, it is used against diarrhea, skin infection, inflammation and fever. The plant has never been subjected to in vivo anti-inflammatory activity. Therefore, the objective of the present study was to evaluate anti-inflammatory effect of C. wallichii leaves in rats. Hydro-alcohol extract was prepared and fractionated using n-hexane, chloroform and ethyl acetate. Carrageenan induced paw edema and cotton pellet granuloma model were employed for acute and chronic inflammation respectively. Hydro-alcohol extract showed significant (p <0.05) anti-inflammatory activity. Furthermore, amongst various fractions of hydro-alcohol extract, only n-hexane fraction exhibited potent anti-inflammatory activity (p < 0.05) at a dose of 50 & 100 mg/kg., p.o. The findings of present investigation indicate that C. wallichii has a strong anti-inflammatory activity and could constitute a potential source for the development of new drug for the treatment of inflammatory disorders.
Yeast as Biotechnological Tool in Food Industry
Authors: A Elkhateeb Waill
Published: June 2023

Yeasts are widely spread in nature. Fermentation of sugars by yeast is the oldest and largest application of this technology. Many types of yeasts are used for making many foods: baker’s yeast in bread production, brewer’s yeast in beer fermentation, and yeast in wine. This work describes the prevalence of yeasts in food products.
Highlights on Unique Orange Pore Cap Mushroom Favolaschia Sp. and Beech Orange Mushroom Cyttaria sp. and Their Biological Activities
Authors: A Elkhateeb Waill
Published: June 2023

Fungi exist everywhere around us. However, edible Mushrooms represent promising source for novel compounds with potential uses in different biotechnological fields. Many mushrooms were sources of novel compounds showing biological actions such as antimicrobial, anticancer, antiinflammatory activities. Likewise, mushrooms are macrofungi that exist everywhere around us. They have significant roles in human life as source of nutrition and bioactive compounds. Many mushrooms have been reported as promising biotechnological tools for production of secondary metabolites of various biological activities. Favolaschia sp.; Cyttaria sp. mushrooms are especially interesting due to the rareness of Basidiomycetes. In this review, the ecology, occurrence, of unique Favolaschia sp.; Cyttaria sp. mushrooms were described, and their biological activities.
Current Status and Challenges of Serialization in Pharma Industry
Authors: Dattatreya Galande Amol
Published: June 2023

Access to safe and quality medicines to all is long stated goal of healthcare agencies across the globe. Pharmaceutical industry has reached the new milestones with respect to quality of the manufactured medicines due to combined efforts of all - industries, regulators, international agencies etc. However merely manufacturing of quality medicines does not necessarily guarantee its access to those in need. In fact, more organized efforts are required to control the counterfeit medicine trade which is finding easy access to the countries in the world, especially middle or low income countries having weak legal framework of drug regulations. Pharmaceutical serialization is proving to be critical tool to help control the illegal trade across the globe. Though serialization and subsequent aggregation is getting good pace in recent time, the implementation of the system is having some challenges. Adaptation of the serialization, its current status and the difficulties involved for industry is discussed in the current review.
Preparation and Characterization of Sodium Alginate- Eudragit E100 Based Systems with Prospective Pharmaceutical Delivery to Application
Authors: Voycheva Christina
Published: June 2023

Regarding the preparation of a local drug delivery system, the possibility of incorporating an active substance in a matrix system was investigated to prolong the drug release. A complex between sodium alginate and a triple copolymer of dimethyl aminoethyl methacrylate was prepared in the presence of a cross-linking agent- malic acid. The formation of a polyelectrolyte complex was proven by turbidimetry, determining the specific viscosity of the diluted solutions of sodium alginate, EE 100, malic acid with IR spectroscopy.
Healthful Plants in COVID-19: Progression and Limitations
Authors: Elkhateeb Waill
Published: June 2023

Presently, research is going for the evolution of treatment for avoidance of novel pandemic Covid-19. Despairness among communities (especially within the middle class or low economic people), due to lockdown and economic impact, has forced discoveries of alternate ways of treatment and prevention of this novel problem. It’s become clear as a result of the rise in genuine allegations about these treatments circulating on social media. Azadirachta indica, Eurycoma longifolia, Nigella Sativa, and Vernonina amygdalina are some medicinal plants that have been shown to be useful in the treatment of this disease. The strong anti-viral potentials of these plants including anti-inflammatory and immunomodulatory activity are used for the management of this disease effectively. The authoritative bit part of these healing herbs in cytokine storms and postdisease complications need to be investigated further. The importance of QC and normalization commodities should also be emphasized. Notwithstanding, given the phenomenal difficulties confronted, Ethnopharmacological exploration ought to be given a decent measure of thought for commitment in this pandemic.
On Rational Design of Precision Drugs
Authors: Petrak Karel
Published: June 2023

The rational design of perfect precision drugs must be based on a precise definition of the disease’s molecular target. This article offers a perspective on how the current drug development process needs to change to respond to this demand. This is not a review. However, the article refers to the past drug development to illustrate what needs to be done to progress to the next stage, namely the development of precision drugs–drugs that would act on diseases with no, or at least very much reduced side effects. To this end, unique molecular structures associated with diseases must be identified, followed by developing drugs that would bind specifically to such structures. Finally, future drug development must adopt this new paradigm.
In-silico Study for African Plants with Possible Beta-Cell Regeneration Effect through Inhibition of DYRK1A
Authors: IfedibaluChukwu Ejiofor InnocentMary
Published: June 2023

Background: The continuous destruction of normal insulin-producing pancreatic beta cells is a contributing factor in all common forms of diabetes, due to insufficient production of insulin, especially in type 1 diabetes. There are attempts to betacells transplantation, but the cost and availability of donors pose a great challenge to the process. Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A plays a crucial role in beta-cells destruction. Aims: Our research targets to identify plants for that can be utilized possible alternative approach of beta-cell replacement through a pharmacologically induced regeneration of new beta cells in-silico. Methods and Material: The 3D structure Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A and 6511 phytochemicals were obtained from Protein Databank and African Natural Products Database respectively. They were appropriately prepared for molecular docking simulations. Molecular docking simulations were implemented, after validation of docking protocols, in AutoDock-Vina®, using virtual screening scripts. Phytocompounds with good binding affinities for Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A were selected as frontrunners. The compounds were screened for toxicity and Lipinski’s rule confirmation using Datawarrior and then kinase inhibitory bioactivity prediction using Molinspiration. Results: Twelve phytocompounds were found to be predictably highly active in-silico against Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A, druglike based on Lipinski’s rule, non-mutagenic, non-tumorigenic, no reproductive effect and non-irritant, with high bioactivity prediction. Conclusions: In-silico active phytocompounds against Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A with their plant sources and physicochemical parameters were identified. Further studies will be carried out in-vitro and in-vivo in to validate the results of this study using plants containing the identified phytocompounds.
Therapeutic Values of Ganoderma Oregonense and Ganoderma Pfeifferi, Mushrooms: A Review
Authors: Elkhateeb Waill A
Published: June 2023

Spreading of new diseases as well as the weakness of some currently used drugs have directed scientists towards screening for new sources of biologically active compounds. Mushrooms are macrofungi that are famous for being rich sources of bioactive and nutritional compounds from different chemical classes. Out of mushrooms genera, the genus Ganoderma is one of the most famous due to its richness in compounds of beneficial values and generally it’s classified among the well-studied genera. Hence, we are focusing in this review on the therapeutic potentials of the two Ganoderma species G. oregonense and G. pfeifferi. Their description and ecology were discussed. Also, we highlighted their reported biological activities and some of the compounds responsible for these activities
Lichen Secondary Metabolites as Anti-Fungal Agent: A Review
Authors: Elkhateeb Waill A
Published: June 2023

Lichens are found on every landform and have a history of use as food, medicine, dyes, livestock feed and other fields. The pharmaceutical potential of lichens is high and several companies are now attempting to commercialise these unique agents. The secondary metabolites that lichen produces have a wide range of biological functions, including antibacterial, antiviral, antitumor, antioxidant, antiherpes, allelochemical, insecticidal, and allergenic effect. The purpose of this review was to systematically evaluate the literature on the biologically active secondary metabolites of lichen
ANALYSIS OF THE RADIOISOTOPES RECOGNITION POSSIBILITY BY MEANS OF THE ABSORBED DOSE MEASUREMENT WITH DOSIMETRIC DETECTORS OF DIFFERENT DENSITY
Authors:   Lviv Polytechnic National University, Ubizskii S. , Poshyvak O. , Zhydachevskii Ya ,   Institute of Physics, Polish Academy of Sciences
Published: June 2023

The work is devoted to the problem of identifying an unknown source of g-radiation as a task of emergency dosimetry in the case of the use for terrorist purposes of the radiation-dispersive devices, known also as dirty bomb. The possibility of identifying an unknown g-source is considered based on the energy dependence of the absorption of ionizing photon radiation, which in passive dosimetry manifests itself as dosimetric sensitivity. Radioisotope recognition is analyzed by the ratio of dosimetric sensitivities of heavy (with a high value of the effective atomic number Zeff) and light (with a low Zeff value) dosimetric detectors, for the values of g-radiation energies of those radioisotopes that can probably be used to create a dirty bomb. As a light dosimetric detector, BeO ceramics is considered, and as a heavy one, a dosimetric detector based on single crystalline yttrium-aluminum perovskite (YAlO3) or lutetium-aluminum perovskite (LuAlO3). The influence of the accuracy of the absorbed dose measurement on the reliability of radioisotope identification is discussed and approaches for its practical implementation are proposed.
Kielellisesti tuettua opetusta vastasaapuneiden maahanmuuttajasten tueksi (TULOSSA)
Authors: Harju-Autti Raisa
Published: June 2023

Raisa Harju-Autin kielikasvatuksen alaan kuuluva väitöskirja tarkastettiin Tampereen yliopistossa lauantaina 17. joulukuuta 2022. Vastaväittäjänä toimi professori Minna Suni Jyväskylän yliopistosta ja kustoksena professori Marita Mäkinen.
Raisa Harju-Autti: Kielellisesti tuettu opetus: Yläkouluikäiset maahanmuuttajaoppilaat opetuskieltä ja oppiainesisältöjä oppimassa. Tampereen yliopiston väitöskirjat 711.
Kirja on luettavissa osoitteessa https://trepo.tuni.fi/handle/10024/143569.
The Role of Career Women in Creating a Sakinah Family: From Mubadalah (Mutuality) Perspective
Authors: Nastangin Nastangin , Huda Muhammad Chairul
Published: June 2023

Abstract: The Role of Career Women In Creating A Sakīnah Family: From Mubādalah (Mutuality) Perspective. Career women have dual roles, first as a wife and second as a worker. This dual role, either directly or indirectly, will affect their ability to manage domestic life. This study tries to examine this phenomenon through the perspective of mubādalah (mutuality) from Faqihuddin Abdul Kodir. The aim is to find out the success/failure of how career women reconcile their roles as housewives as well as career women. This research is qualitative by using a socio-legal approach. Data were collected using in-depth interview techniques conducted with several female lecturers at IAIN Salatiga. This study finds the fact that the perspective of Mubādalah (Mutuality) theory, when drawn into the realm of family life of female lecturers at IAIN Salatiga, is in line because Mubādalah theory requires a balance of relations between husband and wife and the elimination of gender bias to create a harmonious and prosperous family life.
An Appraisal of The Legality of Translating Jumu’ah Khutbah in Nigeria
Authors: Mustapha Abdur-Razzaq Solagberu Balogun Mustapha Balogun
Published: June 2023

Khutbah is one the stipulated condition that distinguish Jumucah prayer from other obligatory five ritual daily prayers.  By the time Islam spread to what is now known as Nigeria, the Khutbah used to be rendered in Arabic without any attempt to translate it to any local language.  However, with passage of time the population of Muslims continues to increase.  As a result of that, there are agitations and counter-agitation on the need to either translate the khutbah into a local languages or to render it in a vernacular.  The issue of legality comes in as a means of justifying either of the duo agitations.  The objective of this research paper is to examine the legality or otherwise of translating the khutbah especially in a country like Nigeria where a section of the Muslims who observe their Jumu’ah prayer could not comprehend the language in which the khutbah is being delivered. The method adopted in the research is based on both participatory and non-participatory observations.  The end-result of the research reveals that the khutbah can be legally translated considering a large population of the worshippers who could not comprehend the language of communication i.e. Arabic. By extention, the khutbah of religious festivals such as cIdul-Fitr and cIdul-Adha be translated too.  Similarly ceremonial events where Khutbah is rendered in Arabic should also be translated.  All these will afford the larger number of the congregation not only to be exposed to the stand and teachings of Islam on current issues but will also enable them to appreciate the teachings of Islam.
Dynamic Development of Family Law in Muslim Countries
Authors: Idham Idham , Nur Efa Rodiah , Hermanto Agus
Published: June 2023

Abstract: Dynamic Development of Family Law in Muslim Countries. This article examines the dynamics of the development/renewal of Islamic family law in Muslim countries. The aim is to obtain a concrete picture of the development, from its original form, i.e conventional fiqh, to become positive law and apply it in Muslim countries. This research is classified as library research using a combination of historical and socio-anthropological approaches. Data were obtained from several secondary sources in the form of laws and regulations, books, articles, and many other documents related to the topic under study. The results of this study indicate that the role of the state in enforcing a legal system is absolute, in the sense that a law can be applied when it has been legislated as positive law. Apart from that, this study also found the fact that three models are applied in the development of family law in Muslim countries, namely; First, the state still applies the conventional legal system (fiqh). Second, the state carries out legal reforms within the school of thought. Third, the state makes its family law that is separate from religious norms to keep up with changes and developments in society.
The Concept of Impeachment in The Indonesia's Constitutional System From The Perspective of Fiqh Siyasah
Authors: Marwing Anita , Asni Asni , Astuti Widia
Published: June 2023

This study discusses the Siyasah Fiqh Review of the concept of Impeachment in the Indonesian State Administration. The aim is to find out and understand the mechanism for impeachment/dismissal of the President or Vice President in Indonesia's constitutional system as stipulated in Articles 7 a and 7 b of the 1945 Constitution and the fiqh siyasa perspective on these rules. This research belongs to normative legal research that uses normative, juridical, and historical approaches. Data were collected using literary techniques, then analyzed descriptively and qualitatively. The results of this study indicate that the practice of impeaching the President in the past occurred more often due to political issues, namely the disputes between the legislature and the executive regarding the issue that the President had violated the law. In the past two impeachment proceedings, there has been no precise regulation regarding the impeachment mechanism of the President in the country's Constitution. After the amendment, the issue of impeachment was adopted in Articles 7A and 7B of the 1945 Constitution. Article 7A limits the grounds for impeachment, while Article 7B complicates impeachment by the presence of a judicial institution. From the perspective of Fiqh,siyasa, the head of State's impeachment can be carried out if it meets the criteria and reasons that Syara has determined'
Legal Certainty of Arbitration in The Settlement of Islamic Economic Civil Cases in The Perspective of Positive Law in Indonesia
Authors: Saepullah Usep
Published: June 2023

One of Law enforcement efforts can be conducted through a non-litigation approach. In this, arbitration can be seen as a non-litigation legal effort and can be used to resolve Islamic economic civil cases. So far, arbitration law effort has been regulated in the Law Number 30 of 1999 and is widely used in the law enforcement practices. This study uses a normative-juridical method and a qualitative approach. The sources and techniques of data collection refers to the number of relevant literatures, and also analyzed deductively and inductively. The results of this study show that legal certainty of arbitration in the settlement of Islamic economic civil cases in the perspective of positive law in Indonesia that regulated in regulated in the Law Number 30 of 1999 has proven to be quite effective in resolving Islamic economic civil cases. The benefit of Islamic economic civil cases settlement through arbitration is the parties have the same position in the form of equality before the law, the process is easy, not expensive, and a win-win solution. Moreover, arbitration can also guarantee legal certainty and justice for the disputing parties.
Laser Based Vibration Sensor Through Mobile
Authors: Mahapatra Rashmita. K. , Yadav Shalini J. , Yadav Rajan
Published: June 2023

Machine condition monitoring has gained momentum over the years and becoming an essential component in the today’s industrial units. A cost-effective machine condition monitoring system is need of the hour for predictive maintenance. The paper presents the design and implementation using vibration sensor, and also this system operated through smartphones. Vibration analysis plays a major role in detecting machine defects and developing flaws before the equipment fails and potentially damages. The concept of this project was to detect faulty equipment in industry machine so that before damaging the whole machine faulty equipment can be replace and improve the durability of machine.
Application of Augmented Reality-Based Solar System Recognition Using Metaverse Studio
Authors: Ridhoni Izza Wildan , Sholeh Muhammad
Published: June 2023

Learning media is currently developing with various innovations, especially in utilizing information technology. One of the technologies used for the learning process is Augmented Reality (AR). The purpose of the research is to provide alternative learning media using information technology, especially focusing on the use of AR. The learning that will be developed in this case is learning aimed at children to introduce learning about the solar system using interactive AR. The content of the learning media developed includes several things, namely learning the solar system and quizzes to test children's knowledge about the solar system. The research method used in developing learning media uses the Research and Development (R&D) method. The application development process can be done by adding features. The results of this study produce an AR-based application that describes learning the solar system in 2D/3D form and is equipped with a quiz to train children's knowledge.
David Mauricio Adriano Solodkow, Mestizaje inconcluso, raza y gobierno de la población. Luis López de Mesa y el ensayo biopolítico en Colombia. Bogotá, Ediciones Uniandes, 2022, 330 páginas
Authors: Castañeda Vargas Carolina
Published: June 2023

Reseña de David Mauricio Adriano Solodkow, Mestizaje inconcluso, raza y gobierno de la población. Luis López de Mesa y el ensayo biopolítico en Colombia. Bogotá, Ediciones Uniandes, 2022, 330 páginas
María del Carmen González de León, El palimpsesto intencionado. El proyecto literario de Felisberto Hernández. Montevideo, +Quiroga Ediciones, 2022, 452 páginas
Authors: Pérez Facio Magdalena
Published: June 2023

Reseña de María del Carmen González de León, El palimpsesto intencionado. El proyecto literario de Felisberto Hernández. Montevideo, +Quiroga Ediciones, 2022, 452 páginas
Penerapan Model Diskursus Multy Representasi : Dampaknya terhadap Kemampuan Pemahaman Konsep Matematis dan Self Eficacy
Authors: Amani Fauziyah , Pratiwi Dona Dinda , Anggoro Bambang Sri
Published: June 2023

Abstract:The Multy Representation Discourse is a learning model that emphasizes students learning in groups and the use of representation. This study aims to determine the influence of the DMR model on the ability to understand mathematical concepts and the self-efficacy of students. The research design uses Quasy Experimental Design with a posttest-only control design. The population was all class VIII students at one of the MTs in Krui. The sample number of 50 students consisted of 25 in the experimental class and 25 in the control class taken by the cluster random sampling technique. Hypothesis testing using Multivariate Analysis of Variance (Manova). The results showed that students who learned with the DMR learning model had better concept understanding and self-efficacy skills than students who learned using the direct learning model.Abstrak:Diskursus Multy Representasi (DMR) merupakan model pembelajaran yang menekankan peserta didik untuk belajar berkelompok dan pemanfaatan representasi. Penelitian bertujuan mengetahui pengaruh model DMR terhadap kemampuan pemahaman konsep matematis dan self efficacy peserta didik. Rancangan penelitian menggunakan Quasy Experimental Design dengan posttest-only control design. Populasi penelitian ini adalah seluruh peserta didik kelas VIII pada salah satu MTs di Krui. Jumlah sampel 50 peserta didik terdiri dari 25 di kelas eksperimen dan 25 di kelas kontrol yang diambil dengan teknik cluster random sampling. Pengujian hipotesis menggunakan Multivariate Analysis of Variance (Manova). Hasil penelitian menunjukkan Peserta didik yang belajar dengan model pembelajaran DMR memiliki kemampuan pemahaman konsep dan self efficacy yang lebih baik dibandingkan peserta didik yang belajar menggunakan model pembelajaran langsung.