bluuebunny/crossref_metadata_2025 huggingface dataset:
Underlying Factors Explaining Physical Behaviors among Office Workers—An Exploratory Analysis
Authors: Wahlström Viktoria , Olsson David , Öhberg Fredrik , Olsson Tommy , Slunga Järvholm Lisbeth
Published: December 2020

Studies using technical measurements of physical behavior show wide interindividual variations. This study aimed to explore underlying factors related to sitting, standing and walking among office workers. Cross-sectional data for background characteristics, work-related variables, and device-based measures for sitting, standing and walking were collected among office workers in either a cell office or a flex office with activity-based work. Data were analyzed by Factor Analysis of Mixed Data (FAMD) and multiple robust linear regression. The FAMD resulted in the combination of underlying factors describing six character types. The (1) harmonic and healthy, (2) disabled with poor health, (3) manager that spend a lot of time in meetings and has very high workload, (4) engaged with high workload, (5) employee with creative and computer intense work, with high workload and, (6) employee with high BMI with creative and collaborative work. Regression analysis showed that the character type that was “engaged with high workload” sat more and stood less, while the character type with ”high BMI and with creative and collaborative work” sat less. The results suggest that physical behavior among office workers is influenced by a complex combination of factors, which should be taken into account in the evaluation of future studies of larger cohorts.
Trends in Social Acceptance of Renewable Energy Across Europe—A Literature Review
Authors: Segreto Marco , Principe Lucas , Desormeaux Alexandra , Torre Marco , Tomassetti Laura , Tratzi Patrizio , Paolini Valerio , Petracchini Francesco
Published: December 2020

Social acceptance has proven to be a significant barrier in the implementation of renewable energy systems (hereinafter “RES”). While a general acceptance of RES is high, low local acceptance has hindered the development of renewable energy projects (hereinafter “REP”). This study assesses the determinants of local and general social acceptance of REP across Europe through a qualitative analysis from 25 case studies of the most significant social drivers and barriers that include all European countries. These case studies contain qualitative and quantitative analyses of the main factors for social acceptance of many representative groups including residents, stakeholders, and experts. Understanding the influences of social acceptance enables us to create strategies that will promote the development of REP by mitigating any public opposition.
The Impact of Angiogenesis in the Most Common Salivary Gland Malignant Tumors
Authors: Pouloudi Despoina , Sotiriadis Aristoteles , Theodorakidou Margarita , Sarantis Panagiotis , Pergaris Alexandros , Karamouzis Michalis V. , Theocharis Stamatios
Published: December 2020

Salivary gland carcinomas (SGCs) represent a group of rare tumors, with complete surgical resection being the main treatment option. Therapeutic armory for cases of locally aggressive, recurrent, and/or metastatic SGCs, though, remains poor since they exhibit high rates of resistance to systematic therapy. Angiogenesis is considered one of the contemporary hallmarks of cancer and anti-angiogenic factors have already been approved for the treatment of several cancer types. This review aims to summarize, in a histotype-specific manner, the most current available data on the angiogenic factors implicated in SGC angiogenesis, in order to highlight the differences between the most common SGC histotypes and the factors that may have a potential role as therapeutic targets.
Insights into Bioinformatic Applications for Glycosylation: Instigating an Awakening towards Applying Glycoinformatic Resources for Cancer Diagnosis and Therapy
Authors: Muthu Manikandan , Chun Sechul , Gopal Judy , Anthonydhason Vimala , Haga Steve W. , Jacintha Prameela Devadoss Anna , Oh Jae-Wook
Published: December 2020

Glycosylation plays a crucial role in various diseases and their etiology. This has led to a clear understanding on the functions of carbohydrates in cell communication, which eventually will result in novel therapeutic approaches for treatment of various disease. Glycomics has now become one among the top ten technologies that will change the future. The direct implication of glycosylation as a hallmark of cancer and for cancer therapy is well established. As in proteomics, where bioinformatics tools have led to revolutionary achievements, bioinformatics resources for glycosylation have improved its practical implication. Bioinformatics tools, algorithms and databases are a mandatory requirement to manage and successfully analyze large amount of glycobiological data generated from glycosylation studies. This review consolidates all the available tools and their applications in glycosylation research. The achievements made through the use of bioinformatics into glycosylation studies are also presented. The importance of glycosylation in cancer diagnosis and therapy is discussed and the gap in the application of widely available glyco-informatic tools for cancer research is highlighted. This review is expected to bring an awakening amongst glyco-informaticians as well as cancer biologists to bridge this gap, to exploit the available glyco-informatic tools for cancer.
Genomic Analysis of Natural Rough Brucella melitensis Rev.1 Vaccine Strains: Identification and Characterization of Mutations in Key Genes Associated with Bacterial LPS Biosynthesis and Virulence
Authors: Kornspan David , Lubkovskaia Regina , Mathur Shubham , Yeheskel Adva , Salmon-Divon Mali
Published: December 2020

Brucella species are facultative intracellular bacteria that cause brucellosis, a zoonotic world-wide disease. The live attenuated B. melitensis Rev.1 vaccine strain is widely used for the control of brucellosis in the small ruminant population. However, Rev.1 induces antibodies against the O-polysaccharide (O-PS) of the smooth lipopolysaccharide thus, it is difficult to differentiate between infected and vaccinated animals. Hence, rough Brucella strains lacking the O-PS have been introduced. In the current study, we conducted a comprehensive comparative analysis of the genome sequence of two natural Rev.1 rough strains, isolated from sheep, against that of 24 Rev.1 smooth strains and the virulent reference strain B. melitensis 16M. We identified and characterized eight vital mutations within highly important genes associated with Brucella lipopolysaccharide (LPS) biosynthesis and virulence, which may explain the mechanisms underlying the formation of the Rev.1 rough phenotype and may be used to determine the mechanism underlying virulence attenuation. Further complementation studies aimed to estimate the specific role of these mutations in affecting Brucella morphology and virulence will serve as a basis for the design of new attenuated vaccines for animal immunization against brucellosis.
The Evolutionary Significance of RNAi in the Fungal Kingdom
Authors: Lax Carlos , Tahiri Ghizlane , Patiño-Medina José Alberto , Cánovas-Márquez José T. , Pérez-Ruiz José A. , Osorio-Concepción Macario , Navarro Eusebio , Calo Silvia
Published: December 2020

RNA interference (RNAi) was discovered at the end of last millennium, changing the way scientists understood regulation of gene expression. Within the following two decades, a variety of different RNAi mechanisms were found in eukaryotes, reflecting the evolutive diversity that RNAi entails. The essential silencing mechanism consists of an RNase III enzyme called Dicer that cleaves double-stranded RNA (dsRNA) generating small interfering RNAs (siRNAs), a hallmark of RNAi. These siRNAs are loaded into the RNA-induced silencing complex (RISC) triggering the cleavage of complementary messenger RNAs by the Argonaute protein, the main component of the complex. Consequently, the expression of target genes is silenced. This mechanism has been thoroughly studied in fungi due to their proximity to the animal phylum and the conservation of the RNAi mechanism from lower to higher eukaryotes. However, the role and even the presence of RNAi differ across the fungal kingdom, as it has evolved adapting to the particularities and needs of each species. Fungi have exploited RNAi to regulate a variety of cell activities as different as defense against exogenous and potentially harmful DNA, genome integrity, development, drug tolerance, or virulence. This pathway has offered versatility to fungi through evolution, favoring the enormous diversity this kingdom comprises.
The Clicking Elateroidea from Chinese Mesozoic Deposits (Insecta, Coleoptera)
Authors: Muona Jyrki , Chang Huali , Ren Dong
Published: December 2020

Recent molecular studies have suggested that the clicking beetle families Elateridae, Eucnemidae, Throscidae, and Cerophytidae evolved in the Jurassic and diversified in the Cretaceous. These studies paid little attention to fossils, using them only as dating tools. The identification of Elateridae fossils is challenging, as external synapomorphies are not known for this family. Elateridae can be identified only as something not belonging to the other related families, all of which have diagnostic synapomorphies. Most subfamilies and tribes of Elateridae do possess definite diagnostic characters, however, making their identification feasible. We checked the 28 Elateridae described from Chinese Mesozoic deposits. Twelve were Elateridae, seven were Eucnemidae, and one was a Throscidae. Three species could be Eucnemidae, but showed aberrant characters. Five species could not be placed and may not belong to Elateroidea at all. On the basis of these results we suggest that all previously described Elateridae fossils should be re-checked. They should be searched for synapomorphies defining Eucnemidae, Throscidae, and Cerophytidae. If such characters are not present, a click beetle type of fossil can be placed in Elateroidae incertae sedis. The Mesozoic Chinese Elateridae fossils all belong to clades that do not exist today, whereas the Mesozoic Eucnemidae subfamilies are extant ones. This may be the source of the disagreement between Elateridae fossil age and datings based on molecular studies. One new combination was made: Desmatus ponomarenkoi (Chang, Kiretjshuk & Ren, 2009) NEW COMBINATION (= Paradesmatus ponomarenkoi Chang, Kirejtshuk & Ren, 2009).
Biceps Tenodesis Versus Tenotomy with Fast Rehabilitation Protocol—A Functional Perspective in Chronic Tendinopathy
Authors: Zabrzyński Jan , Huri Gazi , Gryckiewicz Szymon , Çetik Rıza Mert , Szwedowski Dawid , Łapaj Łukasz , Gagat Maciej , Paczesny Łukasz
Published: December 2020

The study aimed to evaluate the results after arthroscopic tenodesis and tenotomy of the biceps tendon (LHBT), coupled in tenotomy modality with a personalized postoperative rehabilitation protocol. The study included patients who underwent arthroscopic biceps tenotomy or tenodesis due to chronic biceps tendinopathy. Postoperatively, a standard rehabilitation program was prescribed to the tenodesis group and personalized was introduced in the tenotomy group, respectively. The outcomes were assessed using the American Shoulder and Elbow Surgeons scale (ASES), clinical tests that are dedicated to biceps tendinopathy, the occurrence of a Popeye deformity, night pain, and return to previous sporting activities. A cohort of 67 patients was enrolled in the final follow-up examination (mean 27 months) of which 40 patients underwent tenotomy (60%), and 27 patients (40%) underwent tenodesis. The mean ASES score improved from 48.1 to 87.8 in the tenotomy group and from 44 to 72.7 in the tenodesis group during the follow-up (p < 0.0001). The tenotomy group had better mean postoperative ASES scores than the tenodesis group (p < 0.0001). Positive clinical tests for biceps pathology were noticed more often in patients after LHB tenodesis (p = 0.0541). The Popeye deformity occurred more often in the tenotomy group; however, no patient complained of the visual appearance of the arm contour (p = 0.0128). Moreover, the frequency of night pain decreased in the tenotomy group (p = 0.0059). Return to previous sporting activities was more frequent in the tenotomy group (p = 0.0090). Arthroscopic biceps tenotomy is a reproducible, simple procedure, and augmented by a rapid rehabilitation protocol that provides promising clinical outcomes, reduces shoulder pain, and allows the patient to return to previous sporting activities, even in population older than 50 years.
Left Atrial Appendage Morphology and Left Atrial Wall Thickness Are Associated with Cardio-Embolic Stroke
Authors: Adukauskaite Agne , Barbieri Fabian , Senoner Thomas , Plank Fabian , Knoflach Michael , Boehme Christian , Hintringer Florian , Mueller Silvana , Bauer Axel , Feuchtner Gudrun , Dichtl Wolfgang
Published: December 2020

Background. New markers for stroke risk stratification in patients with atrial fibrillation (AF) are on demand. Hence, we aimed to investigate the association of left atrial appendage (LAA) and left atrium (LA) morphological parameters in patients with cardio-embolic (CE) stroke due to AF in comparison to controls without stroke. Methods: A retrospective analysis of cardiac computed tomography angiography (CTA) examinations performed between 2006 and 2017 for clinical indications in 158 patients (median age 65 (54–73) years, 48.7% females) was conducted: 56 patients with CE stroke were compared to 102 controls not differing in gender, body mass index (BMI) and CHA2DS2-VASc score. Results: On multivariable regression analysis adjusted for CHA2DS2-VASc score and LA diameter CE stroke was independently associated with the following parameters: windsock LAA type (OR 2.55; CI: 1.04–6.26, p = 0.041), a greater lobe number (OR 1.54; CI: 1.13–2.10, p = 0.006), a greater LAA ostium area (OR 1.88; CI: 1.38–2.55, p < 0.001) and a greater left atrium wall thickness (LAWT) in the middle and right part, measured along the anterior LA wall in the axial plane (respectively, OR 1.94; CI: 1.26–3.0, p = 0.003 and OR 1.57; CI: 1.07–2.31, p = 0.021). Conclusions: The windsock LAA type, a greater LAA lobe number, a larger LAA ostium and a greater LAWT are associated with CE stroke. These CTA parameters could improve risk stratification for thromboembolic stroke.
Insolation and Disease Severity in Paediatric Inflammatory Bowel Disease—A Multi-Centre Cross-Sectional Study
Authors: Glapa-Nowak Aleksandra , Szczepanik Mariusz , Kwiecień Jarosław , Szaflarska-Popławska Anna , Flak-Wancerz Anna , Iwańczak Barbara , Osiecki Marcin , Kierkuś Jarosław , Pytrus Tomasz , Lebensztejn Dariusz , Banasiewicz Tomasz , Banaszkiewicz Aleksandra , Walkowiak Jarosław
Published: December 2020

This study was to investigate whether the clinical course of inflammatory bowel disease (IBD) in a Polish paediatric cohort fits a seasonal pattern and depends on insolation. Two hundred and fourteen patients diagnosed with Crohn’s disease (CD) and 192 with ulcerative colitis (UC) aged from 3 to 18 years, were recruited in seven centres of similar latitude. The seasons were defined as winter (December–February), spring (March–May), summer (June–August), autumn (September–November). The year was also divided depending on insolation threshold (3.0 kWh/m2/day). Patients diagnosed with IBD when the isolation was >3 kWh/m2/day had poorer nutritional status than those diagnosed while insolation was below threshold (lower standardised BMI at diagnosis (−0.81 ([−1.34]–[−0.03]) vs. −0.52 ([−1.15]–0.15); p = 0.0320) and worst flare (−0.93 ([−1.37]–[−0.05]) vs. −0.66 ([−1.23]–0.17); p = 0.0344), with the need for more frequent biological treatment (45.5% vs. 32.7%, p = 0.0100). Patients diagnosed in winter were significantly younger at diagnosis (11.4 vs. 13.0; padj = 0.0180) and first immunosuppressive treatment (11.3 vs. 13.3; padj = 0.0109) than those diagnosed in other seasons. CD patients diagnosed in months with higher insolation spent more days in hospital than those diagnosed in months with lower insolation [4.6 (1.8–11.8) vs. 2.9 (1.3–6.2); p = 0.0482]. CD patients diagnosed in summer had significantly more concomitant diseases. In patients with CD, the occurrence of the worst flare was more frequent in autumn. Furthermore, the season of birth was associated with Pediatric Crohn’s Disease Activity Index at worst flare and earlier surgery. In conclusion, several clinical parameters are associated with insolation, the season of diagnosis and season of birth in the clinical course of Crohn’s disease.
Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist
Authors: Polini Beatrice , Cervetto Chiara , Carpi Sara , Pelassa Simone , Gado Francesca , Ferrisi Rebecca , Bertini Simone , Nieri Paola , Marcoli Manuela , Manera Clementina
Published: December 2020

Preclinical studies highlighted that compounds targeting cannabinoid receptors could be useful for developing novel therapies against neurodegenerative disorders. However, the chronic use of orthosteric agonists alone has several disadvantages, limiting their usefulness as clinically relevant drugs. Positive allosteric modulators might represent a promising approach to achieve the potential therapeutic benefits of orthosteric agonists of cannabinoid receptors through increasing their activity and limiting their adverse effects. The aim of the present study was to show the effects of positive allosteric ligands of cannabinoid receptors on the activity of a potent dual orthosteric agonist for neuroinflammation and excitotoxic damage by excessive glutamate release. The results indicate that the combination of an orthosteric agonist with positive allosteric modulators could represent a promising therapeutic approach to the treatment of neurodegenerative disorders.
Subclasses of Multivalent Analytic Functions Associated with a q-Difference Operator
Authors: Ali Ekram Elsayed , Bulboacă Teodor
Published: December 2020

In this article we introduced and studied some inclusion properties for new subclasses of multivalent analytic functions defined by using the q-derivative operator. With the aid of the Jackson q-derivative we defined two new operators that generalize many other previously studied operators, and help us to define two new subclasses of functions with several interesting properties studied in this paper. The methods used for the proof of our results are special tools of the differential subordination theory of one-variable functions.
Effects of Leading-Edge Modification in Damaged Rotor Blades on Aerodynamic Characteristics of High-Pressure Gas Turbine
Authors: Mai Thanh Dam , Ryu Jaiyoung
Published: December 2020

The flow and heat-transfer attributes of gas turbines significantly affect the output power and overall efficiency of combined-cycle power plants. However, the high-temperature and high-pressure environment can damage the turbine blade surface, potentially resulting in failure of the power plant. Because of the elevated cost of replacing turbine blades, damaged blades are usually repaired through modification of their profile around the damage location. This study compared the effects of modifying various damage locations along the leading edge of a rotor blade on the performance of the gas turbine. We simulated five rotor blades—an undamaged blade (reference) and blades damaged on the pressure and suction sides at the top and middle. The Reynolds-averaged Navier–Stokes equation was used to investigate the compressible flow in a GE-E3 gas turbine. The results showed that the temperatures of the blade and vane surfaces with damages at the middle increased by about 0.8% and 1.2%, respectively. This causes a sudden increase in the heat transfer and thermal stress on the blade and vane surfaces, especially around the damage location. Compared with the reference case, modifications to the top-damaged blades produced a slight increase in efficiency about 2.6%, while those to the middle-damaged blades reduced the efficiency by approximately 2.2%.
Procoagulant Disorders in Patients with Newly Diagnosed Pancreatic Adenocarcinoma
Authors: Talar-Wojnarowska Renata , Woźniak Małgorzata , Borkowska Anna , Cypryk Katarzyna , Olakowski Marek , Małecka-Panas Ewa
Published: December 2020

Background and objectives: Cancer coagulopathy is thought to be partially due to the up-regulation of tissue factor (TF), thrombin-antithrombin complex (TAT) and soluble P-selectin (sP-selectin). The purpose of this study was to evaluate the clinical significance of TF, TAT and sP-selectin in patients with pancreatic cancer. Materials and methods: The study included 93 subjects: 73 newly diagnosed patients with pancreatic adenocarcinoma (42 with stage I-III and 31 with metastatic cancer (stage IV)) and a control group of 20 healthy subjects. Analyzed patients were hospitalized in the Department of Digestive Tract Diseases, Medical University of Lodz or in the Department of Digestive Tract Surgery, Silesian University, Katowice, Poland. All laboratory parameters were measured using ELISA procedures. Results: TF plasma levels were detectable in all patients and were significantly higher in metastatic cancer compared to stage I-III patients and the control group (p < 0.05). In patients with pancreatic adenocarcinoma, the median levels of TAT were also elevated compared to the control group. Moreover, patients with metastases had significantly higher TAT concentration compared to the I-III cancer group. On the other hand, only the metastatic patients group showed significantly higher plasma sP-selectin levels compared to the controls (p = 0.009), whereas there was no difference between localized and metastatic cancer patients. Conclusions: The coagulation disorders are present in the majority of patients with pancreatic adenocarcinoma already at the diagnosis stage and reflect cancer progression and spread.
Update on COVID-19 Myocarditis
Authors: Agdamag Arianne Clare C. , Edmiston Jonathan B. , Charpentier Victoria , Chowdhury Mohammed , Fraser Meg , Maharaj Valmiki R. , Francis Gary S. , Alexy Tamas
Published: December 2020

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) gained worldwide attention at the end of 2019 when it was identified to cause severe respiratory distress syndrome. While it primarily affects the respiratory system, we now have evidence that it affects multiple organ systems in the human body. Cardiac manifestations may include myocarditis, life threatening arrhythmias, acute coronary syndrome, systolic heart failure, and cardiogenic shock. Myocarditis is increasingly recognized as a complication of Coronavirus-19 (COVID-19) and may result from direct viral injury or from exaggerated host immune response. The diagnosis is established similar to other etiologies, and is based on detailed history, clinical exam, laboratory findings and non-invasive imaging studies. When available, cardiac MRI is the preferred imaging modality. Endomyocardial biopsy may be performed if the diagnosis remains uncertain. Current management is mainly supportive with the potential addition of interventions recommended for severe COVID-19 disease, such as remdesivir, steroids, and convalescent plasma. In the setting of cardiogenic shock and refractory, life-threatening arrhythmias that persist despite medical therapy, advanced mechanical circulatory support devices should be considered. Ultimately, early recognition and aggressive intervention are key factors in reducing morbidity and mortality. Our management strategy is expected to evolve further as we learn more about COVID-19 disease and the associated cardiac complications.
Spraying of Ultrathin Isoporous Block Copolymer Membranes—A Story about Challenges and Limitations
Authors: Bucher Thomas , Clodt Juliana Isabel , Abetz Clarissa , Bajer Barbara , Filiz Volkan
Published: December 2020

Isoporous membranes can be prepared by a combination of self-assembly of amphiphilic block copolymers and the non-solvent induced phase separation process. As the general doctor-blade technique suffers from high consumption of expensive block copolymer, other methods to reduce its concentration in the casting solution are sought after. Decreasing the block copolymer concentration during membrane casting and applying the block copolymer solution on a support membrane to obtain ultrathin isoporous membrane layers with e.g., spraying techniques, can be an answer. In this work we focused on the question if upscaling of thin block copolymer membranes produced by spraying techniques is feasible. To upscale the spray coating process, three different approaches were pursued, namely air-brush, 1-fluid nozzles and 2-fluid nozzles as generally used in the coating industry. The different spraying systems were implemented successfully in a membrane casting machine. Thinking about future development of isoporous block copolymer membranes in application it was significant that a continuous preparation process can be realised combining spraying of thin layers and immersion of the thin block copolymer layers in water to ensure phase-separation. The system was tested using a solution of polystyrene-block-poly(4-vinylpyridine) diblock copolymer. A detailed examination of the spray pattern and its homogeneity was carried out. The limitations of this method are discussed.
Lysosomal Exocytosis: The Extracellular Role of an Intracellular Organelle
Authors: Tancini Brunella , Buratta Sandra , Delo Federica , Sagini Krizia , Chiaradia Elisabetta , Pellegrino Roberto Maria , Emiliani Carla , Urbanelli Lorena
Published: December 2020

Lysosomes are acidic cell compartments containing a large set of hydrolytic enzymes. These lysosomal hydrolases degrade proteins, lipids, polysaccharides, and nucleic acids into their constituents. Materials to be degraded can reach lysosomes either from inside the cell, by autophagy, or from outside the cell, by different forms of endocytosis. In addition to their degradative functions, lysosomes are also able to extracellularly release their contents by lysosomal exocytosis. These organelles move from the perinuclear region along microtubules towards the proximity of the plasma membrane, then the lysosomal and plasma membrane fuse together via a Ca2+-dependent process. The fusion of the lysosomal membrane with plasma membrane plays an important role in plasma membrane repair, while the secretion of lysosomal content is relevant for the remodelling of extracellular matrix and release of functional substrates. Lysosomal storage disorders (LSDs) and age-related neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases, share as a pathological feature the accumulation of undigested material within organelles of the endolysosomal system. Recent studies suggest that lysosomal exocytosis stimulation may have beneficial effects on the accumulation of these unprocessed aggregates, leading to their extracellular elimination. However, many details of the molecular machinery required for lysosomal exocytosis are only beginning to be unravelled. Here, we are going to review the current literature on molecular mechanisms and biological functions underlying lysosomal exocytosis, to shed light on the potential of lysosomal exocytosis stimulation as a therapeutic approach.
New Developments and Future Trends in Low-Temperature Hot Stamping Technologies: A Review
Authors: Tong Chenpeng , Rong Qi , Yardley Victoria A. , Li Xuetao , Luo Jiaming , Zhu Guosen , Shi Zhusheng
Published: December 2020

Improvement of the hot stamping process is important for reducing processing costs and improving the productivity and tensile properties of final components. One major approach to this has been to conduct all or part of the process at lower temperatures. The present paper reviews the state of the art of hot stamping techniques and their applications, considering the following aspects: (1) conventional hot stamping and its advanced developments; (2) warm stamping approaches in which complete austenitisation is not attained during heating; (3) hot stamping with a lower forming temperature, i.e., low-temperature hot stamping (LTHS); (4) advanced medium-Mn steels with lower austenitisation temperatures and their applicability in LTHS. Prospects for the further development of LTHS technology and the work required to achieve this are discussed.
Influence of Rolling Temperatures on Interface Microstructure and Mechanical Properties of Multi-Pass Rolling TA1/Q235B Explosive Welded Sheets
Authors: Li Huizhong , Cao Liangming , Liang Xiaopeng , Zhang Wending , Wu Chunping , Zeng Zhiheng , Zhou Chengshang
Published: December 2020

The effect of rolling temperatures on the interface microstructure and mechanical properties is investigated using 2-mm-thick TA1/Q235B composite sheets, which were prepared after nine passes of hot rolling of explosive welded plates. The results show that the vortex region and the transition layer exist in the interface at the explosive welded plate, while only the transition layer exists in the interface after hot rolling. The transition layer is composed of α-Ti, TiC, Fe, and FeTi, and the thickness increases with the increasing rolling temperature. The microhardness of the explosive welded plate is higher than that of the hot-rolling sheet, and the microhardness of interface are higher than that of matrix metals. The interface shear strength and tensile elongation of the hot-rolled sheet increase with the increasing hot rolling temperature, while the ultimate tensile strength (UTS), yield strength (YS) and Young modulus decrease with the increase of hot rolling temperature. The shear strength of sheets is related to the interfacial compounds, and the tensile strength is mainly affected by the grain morphology of the matrix.
The Missing Tailed Phages: Prediction of Small Capsid Candidates
Authors: Luque Antoni , Benler Sean , Lee Diana Y. , Brown Colin , White Simon
Published: December 2020

Tailed phages are the most abundant and diverse group of viruses on the planet. Yet, the smallest tailed phages display relatively complex capsids and large genomes compared to other viruses. The lack of tailed phages forming the common icosahedral capsid architectures T = 1 and T = 3 is puzzling. Here, we extracted geometrical features from high-resolution tailed phage capsid reconstructions and built a statistical model based on physical principles to predict the capsid diameter and genome length of the missing small-tailed phage capsids. We applied the model to 3348 isolated tailed phage genomes and 1496 gut metagenome-assembled tailed phage genomes. Four isolated tailed phages were predicted to form T = 3 icosahedral capsids, and twenty-one metagenome-assembled tailed phages were predicted to form T < 3 capsids. The smallest capsid predicted was a T = 4/3 ≈ 1.33 architecture. No tailed phages were predicted to form the smallest icosahedral architecture, T = 1. We discuss the feasibility of the missing T = 1 tailed phage capsids and the implications of isolating and characterizing small-tailed phages for viral evolution and phage therapy.
Editorial for Special Issue “Applications of SEM Automated Mineralogy: From Ore Deposits over Processing to Secondary Resource Characterization”
Authors: Schulz Bernhard
Published: December 2020

Matter is particulate [...]
Improved Pulse-Controlled Conductance Adjustment in Trilayer Resistors by Suppressing Current Overshoot
Authors: Ryu Hojeong , Kim Sungjun
Published: December 2020

In this work, we demonstrate the enhanced synaptic behaviors in trilayer dielectrics (HfO2/Si3N4/SiO2) on highly doped n-type silicon substrate. First, the three dielectric layers were subjected to material and chemical analyses and thoroughly investigated via transmission electron microscopy and X-ray photoelectron spectroscopy. The resistive switching and synaptic behaviors were improved by inserting a Si3N4 layer between the HfO2 and SiO2 layers. The electric field within SiO2 was mitigated, thus reducing the current overshoot in the trilayer device. The reset current was considerably reduced in the trilayer device compared to the bilayer device without a Si3N4 layer. Moreover, the nonlinear characteristics in the low-resistance state are helpful for implementing high-density memory. The higher array size in the trilayer device was verified by cross-point array simulation. Finally, the multiple conductance adjustment was demonstrated in the trilayer device by controlling the gradual set and reset switching behavior.
Effects of Curing Temperature on Bending Durability of Inkjet-Printed Flexible Silver Electrode
Authors: Kim Nam Woon , Lee Duck-Gyu , Kim Kyung-Shik , Hur Shin
Published: December 2020

Flexible electrodes should have a good mechanical durability and electrical properties under even extreme bending and deformation conditions. We fabricated such an electrode using an inkjet printing system. In addition, annealing was performed under curing temperatures of 150, 170, and 190 °C to improve the electrical resistance performance of the electrode. Scanning electron microscopy, X-ray diffraction, nanoindentation, and surface profile measurements were performed to measure and analyze the electrode characteristics and the change in the shape of the coffee ring. The bending deformation behavior of the electrode was predicted by simulations. To confirm the bending durability of the flexible electrode according to different curing temperatures, the bending deformation and electrical resistance were simultaneously tested. It was found that the electrode cured at a temperature of 170 °C could endure 20,185 bending cycles and had the best durability, which was consistent with the predicted simulation results. Moreover, the average specific resistance before the electrode was disconnected was 13.45 μΩ cm, which is similar to the conventional electrode value. These results are expected to increase the durability and life of flexible electrodes, which can be used in flexible electronic devices, sensors, and wearable devices that are subjected to significant bending deformation.
Assessing Mediterranean Diet Adherence with the Smartphone: The Medipiatto Project
Authors: Vasiloglou Maria F. , Lu Ya , Stathopoulou Thomai , Papathanail Ioannis , Faeh David , Ghosh Arindam , Baumann Manuel , Mougiakakou Stavroula
Published: December 2020

The Mediterranean diet (MD) is regarded as a healthy eating pattern with beneficial effects both for the decrease of the risk for non-communicable diseases and also for body weight reduction. In the current manuscript, we propose an automated smartphone application which monitors and evaluates the user’s adherence to MD using images of the food and drinks that they consume. We define a set of rules for automatic adherence estimation, which focuses on the main MD food groups. We use a combination of a convolutional neural network (CNN) and a graph convolutional network to detect the types of foods and quantities from the users’ food images and the defined set of rules to evaluate the adherence to MD. Our experiments show that our system outperforms a basic CNN in terms of recognizing food items and estimating quantity and yields comparable results as experienced dietitians when it comes to overall MD adherence estimation. As the system is novel, these results are promising; however, there is room for improvement of the accuracy by gathering and training with more data and certain refinements can be performed such as re-defining the set of rules to also be able to be used for sub-groups of MD (e.g., vegetarian type of MD).
Intake of 25-Hydroxyvitamin D3 May Reduce the Severity of Upper Respiratory Tract Infection: Post hoc Analysis of a Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study
Authors: Shimizu Yoshiki , Ito Yukihiko , Uotsu Nobuo , Yui Kei
Published: December 2020

To evaluate the effects of 25-hydroxyvitamin D3 (25OHD) on symptoms at the onset of the upper respiratory tract infection (URTI) in subjects with insufficient or deficient serum 25-hydroxyvitamin D levels, we conducted a post hoc analysis of data from a randomized, placebo-controlled study; the subjects received 10 μg of 25OHD per day or a placebo for 16 weeks. The Wisconsin Upper Respiratory Symptom Survey-21 was used to determine URTI. The study endpoints included WURSS-21 scores, number of URTI events, and proportion of medication (antibiotics, antipyretic analgesics) usage. We found that the physical symptom scores for “Runny nose,” “Sneezing,” and “Head congestion” were significantly lower in the 25OHD group than in the placebo group; for all items except “Breathe easily, “the quality of life” scores were significantly improved in the 25OHD group. There was no significant difference in the number of URTI events or the proportion of medication use between the groups. Collectively, the findings of this study indicate that a sufficient 25OHD intake can reduce physical symptoms at the onset of upper respiratory tract infection, particularly nasal symptoms, and may improve the quality of life at the time of onset.
Closing the Gaps to Understand the Tick Transmission of Anaplasma marginale among Giant Anteaters (Myrmecophaga tridactyla) in Argentina
Authors: Guillemi Eliana Carolina , Imbert Mélody , de la Fournière Sofia , Orozco María Marcela , Peña Martinez Jorge , Rosas Ana Carolina , Montenegro Valeria Noely , Farber Marisa Diana
Published: December 2020

Anaplasma marginale, a well-known cattle pathogen of tropical and subtropical world regions, has been previously molecularly characterized in a giant anteater (Myrmecophaga tridactyla) from Corrientes, Argentina. Ticks or other hematophagous arthropod involved in the wild transmission cycle remained unknown. The aim of the present study was to analyze the simultaneous occurrence of A. marginale in blood samples and ticks from giant anteaters from Corrientes in order to investigate if ticks could be relevant in the transmission among these mammals. Blood samples from 50 giant anteaters collected in different years and 26 ticks Amblyomma dubitatum and A. sculptum were studied through the molecular amplification of two unequivocal species-specific genes from A. marginale: msp5 and msp1β. Twenty five giant anteaters and tick organs (salivary glands, gut and oviduct) from 11 ticks tested positive to the A. marginale DNA amplification. The further molecular characterization through MSP1a tandem repeats analysis revealed the presence of genotypes circulating among giant anteaters that had been previously identified in cattle blood samples from the same geographical region. These results confirm the presence of A. marginale in giant anteaters in Corrientes and suggests that A. dubitatum and A. sculptum ticks could be involved in the transmission among giant anteaters. Future studies will determine the role of these tick species in the wild transmission cycle in the study area and the eventual connection with the domestic cycle.
Iron Therapeutics in Women’s Health: Past, Present, and Future
Authors: Mintz Joel , Mirza Jackie , Young Eric , Bauckman Kyle
Published: December 2020

Iron plays a unique physiological role in the maintenance of homeostasis and the pathological outcomes of the female reproductive tract. The dual nature of elemental iron has created an evolutionary need to tightly regulate its biological concentration. The female reproductive tract is particularly unique due to the constant cycle of endometrial growth and shedding, in addition to the potential need for iron transfer to a developing fetus. Here, iron regulation is explored in a number of physiologic states including the endometrial lining and placenta. While iron dysregulation is a common characteristic in many women’s health pathologies there is currently a lack of targeted therapeutic options. Traditional iron therapies, including iron replacement and chelation, are common treatment options for gynecological diseases but pose long term negative health consequences; therefore, more targeted interventions directed towards iron regulation have been proposed. Recent findings show potential benefits in a therapeutic focus on ferritin-hepcidin regulation, modulation of reactive oxygen species (ROS), and iron mediated cell death (ferroptosis). These novel therapeutics are the direct result of previous research in iron’s complex signaling pathway and show promise for improved therapy, diagnosis, and prognosis in women’s health.
Lean Management Approach to Reduce Waste in HoReCa Food Services
Authors: Gładysz Bartłomiej , Buczacki Aleksander , Haskins Cecilia
Published: December 2020

A significant share of food waste originates in the food services domain and HoReCa (hotels, restaurants, catering) sector. Organizational improvements leading to the decrease of food waste and costs in restaurants are needed. The literature reports on applications of lean management in service businesses, and while food services belong in this category, the literature contains few works on specific applications in this domain. Those studies are limited mainly to economic aspects. Nor was there evidence of the applicability of lean management to achieve food waste elimination. This article analyzes the applicability of lean management methods for food services in order to achieve efficient operations and eliminate food waste, based on a literature review and three case studies from Poland. Lean management was found to be useful in these cases to decrease food waste and reduce operational costs. The case studies suggest a set of activities for organizations delivering food services to streamline their processes by applying lean management practices. This study contributes to the theory and practice of sustainable restaurant management.
Shadow Detection and Restoration for Hyperspectral Images Based on Nonlinear Spectral Unmixing
Authors: Zhang Guichen , Cerra Daniele , Müller Rupert
Published: December 2020

Shadows are frequently observable in high-resolution images, raising challenges in image interpretation, such as classification and object detection. In this paper, we propose a novel framework for shadow detection and restoration of atmospherically corrected hyperspectral images based on nonlinear spectral unmixing. The mixture model is applied pixel-wise as a nonlinear combination of endmembers related to both pure sunlit and shadowed spectra, where the former are manually selected from scenes and the latter are derived from sunlit spectra following physical assumptions. Shadowed pixels are restored by simulating their exposure to sunlight through a combination of sunlit endmembers spectra, weighted by abundance values. The proposed framework is demonstrated on real airborne hyperspectral images. A comprehensive assessment of the restored images is carried out both visually and quantitatively. With respect to binary shadow masks, our framework can produce soft shadow detection results, keeping the natural transition of illumination conditions on shadow boundaries. Our results show that the framework can effectively detect shadows and restore information in shadowed regions.
Characteristics and Seasonal Variations of Cirrus Clouds from Polarization Lidar Observations at a 30°N Plain Site
Authors: Wang Wei , Yi Fan , Liu Fuchao , Zhang Yunpeng , Yu Changming , Yin Zhenping
Published: December 2020

Geometrical and optical characteristics of cirrus clouds were studied based on one year of polarization lidar measurements (3969 h on 228 different days between March 2019 and February 2020) at Wuhan (30.5°N, 114.4°E), China. The cirrus clouds showed an overall occurrence frequency of ~48% and occurrence mid-cloud altitude of ~8–16 km over the 30°N plain site. The mean values of their mid-cloud height and temperature were 11.5 ± 2.0 km and −46.5 ± 10.7 ℃, respectively. The cirrus geometrical thickness tended to decrease with decreasing mid-cloud temperature, with a mean value of 2.5 ± 1.1 km. With the decrease of mid-cloud temperature, the cirrus optical depth (COD) tended to decrease, but the depolarization ratio tended to increase. On average, the COD, lidar ratio, and particle depolarization ratio were respectively 0.30 ± 0.36, 21.6 ± 7.5 sr, and 0.30 ± 0.09 after multiple scattering correction. Out of a total of the observed cirrus events, sub-visual, thin, and dense cirrus clouds accounted for 18%, 51%, and 31%, respectively. The cirrus clouds showed seasonal variations with cloud altitude maximizing in a slightly-shifted summertime (July to September) where the southwesterly wind prevailed and minimizing in winter months. Seasonally-averaged lidar ratio and depolarization ratio showed maximum values in spring and summer, respectively. Furthermore, a positive correlation between the cirrus occurrence frequency and dust column mass density was found in other seasons except for summer, suggesting a heterogeneous ice formation therein. The cirrus cloud characteristics over the lidar site were compared with those observed at low and mid latitudes.
Change Detection within Remotely Sensed Satellite Image Time Series via Spectral Analysis
Authors: Ghaderpour Ebrahim , Vujadinovic Tijana
Published: December 2020

Jump or break detection within a non-stationary time series is a crucial and challenging problem in a broad range of applications including environmental monitoring. Remotely sensed time series are not only non-stationary and unequally spaced (irregularly sampled) but also noisy due to atmospheric effects, such as clouds, haze, and smoke. To address this challenge, a robust method of jump detection is proposed based on the Anti-Leakage Least-Squares Spectral Analysis (ALLSSA) along with an appropriate temporal segmentation. This method, namely, Jumps Upon Spectrum and Trend (JUST), can simultaneously search for trends and statistically significant spectral components of each time series segment to identify the potential jumps by considering appropriate weights associated with the time series. JUST is successfully applied to simulated vegetation time series with varying jump location and magnitude, the number of observations, seasonal component, and noises. Using a collection of simulated and real-world vegetation time series in southeastern Australia, it is shown that JUST performs better than Breaks For Additive Seasonal and Trend (BFAST) in identifying jumps within the trend component of time series with various types. Furthermore, JUST is applied to Landsat 8 composites for a forested region in California, U.S., to show its potential in characterizing spatial and temporal changes in a forested landscape. Therefore, JUST is recommended as a robust and alternative change detection method which can consider the observational uncertainties and does not require any interpolations and/or gap fillings.