bluuebunny/crossref_metadata_2025 huggingface dataset:
ALTERAÇÕES NEUROQUÍMICAS EM TRANSTORNOS DE HUMOR: NOVAS DESCOBERTAS
Authors: Trettel de Oliveira Maria Clara , De Castro Teixeira Júnior Marcos Antônio , Ataídes Ribeiro Amanda , Veloso Guimarães Heitor , Machado Oliveira Bruno Rafaell , Lemes Cardoso Heloísa , Fernandes dos Santos Letícia , Alves Carvalho Giovanna , Hugueney Hidalgo Natália , Costa Neidemar Maria , Castilho Prado Justiniano , Ferreira de Andrade Ketellyn Kassia , Carvalhaes Filho Carlos Antônio
Published: February 2025

Os transtornos do humor, como a depressão e o transtorno bipolar, são condições psiquiátricas complexas que afetam a regulação emocioal. Tradicionalmente, a serotonina, dopamina e noradrenalina têm sido apontadas como os principais neurotransmissores envolvidos nesses distúrbios. No entanto, novas descobertas indicam que fatores como neuroinflamação, estresse oxidativo, desbalanço nos sistemas GABA-glutamato e a microbiota intestinal também desempenham um papel crucial. Este artigo explora os mecanismos fisiopatológicos dessas doenças, abordando o papel das monoaminas, disfunções no eixo hipotálamo-hipófise-adrenal, processos inflamatórios e alterações na neurotransmissão de dopamina e glutamato. Além disso, discute-se a influência das oscilações de humor na cognição, comportamento e bem-estar do indivíduo.O estudo também analisa a eficácia de intervenções não farmacológicas no manejo dos transtornos do humor, incluindo mudanças na alimentação, atividade física, terapia cognitivo-comportamental, estimulação cerebral e regulação do eixo intestino-cérebro. Essas estratégias emergem como alternativas promissoras para complementar ou, em alguns casos, substituir os tratamentos convencionais, proporcionando melhor qualidade de vida aos pacientes. Dessa forma, a neuroquímica dos transtornos do humor continua a ser um campo de intensa pesquisa, com implicações promissoras para o diagnóstico e tratamento desses distúrbios.
Academic Freedom and Academics’ Right to Criticise their Employer
Authors: Koen Louis
Published: February 2025

Academic freedom is an essential aspect of a democratic society and is recognised as such in international law. In South Africa, academics are generally regarded as employees, and, as such, their freedom of expression may be limited by labour law. The common law imposes a duty of utmost good faith on employees to act in the best interests of their employer, which can restrict an employee’s freedom of expression. Therefore, it is crucial to understand the limitations on an employee’s freedom of expression and how they restrict an employee’s ability to criticise their employer. This chapter considers the existing legal framework regarding an employee’s right to criticise their employer, specifically in the context of academic freedom. The Committee on Economic, Social and Cultural Rights (CESCR) recognises that academic freedom is not absolute and may need to be limited in certain circumstances, including limitations brought about by an academic’s countervailing duties to respect the academic freedom of others, ensure fair discussion of contrary views, and treat all without discrimination on any prohibited grounds. Therefore, academic freedom does not permit an academic to propagate hate speech or discriminatory speech.
Psychological Fundamentals of Work Protection of Economic and Sports Specialists in the Age of Digitalization
Authors:   Ukrainian State University of Science and Technology, Sheviakov Oleksii , Slavska Yanina ,   Dnipro Academy of Music, Cherednichenko Oleksii ,   Khortytsk’a National Educational and Rehabilitation Academy
Published: February 2025

In the age of digitalization, the psychological foundations of occupational health have become increasingly significant for economic and sports specialists. The transition to a digital economy and the growing demands of professional sports necessitate the development of psychological resilience, stress management strategies, and occupational well-being initiatives. This chapter explores the theoretical foundations of occupational health, emphasizing the psychological aspects that influence professional performance in economic and sports fields. The primary aim of this study is to establish a conceptual framework for understanding and improving occupational health among specialists in economic and sports sectors. This study adopts a multi-dimensional approach combining theoretical research, empirical analysis, and case studies. The study involved surveys and structured interviews with 630 economic specialists and sports professionals. The assessment focused on professional stress levels, coping strategies, and the influence of leadership on workplace well-being. Data collected through surveys and case studies were analyzed using statistical tools to identify trends, correlations, and significant predictors of occupational health. The findings of this study highlight the growing importance of psychological resilience and mental well-being in occupational health management. By integrating these elements, organizations can enhance productivity, reduce burnout, and create a sustainable work environment that prioritizes mental well-being. As digital transformation continues to reshape the workforce, organizations must prioritize psychological resilience, stress management, and leadership development to ensure long-term occupational well-being. By fostering a culture of health awareness and proactive intervention, businesses and sports organizations can enhance productivity, employee satisfaction, and overall professional longevity. The insights presented in this chapter serve as a guide for future occupational health strategies, providing a foundation for continued research and policy development in the evolving professional landscape.
Digital Skills as a Fundamental Right: Legal Perspectives on Digital Citi-zenship
Authors:   Grigory Skovoroda Kharkiv National Pedagogical University, Marchenko Volodymyr , Dombrovska Alla ,   O.M. Beketov National University of Urban Economy in Kharkiv
Published: February 2025

In today’s fast-paced world, the unprecedented growth of digital technologies has dramatically reshaped how individuals and society’s function, impacting communication, governance, economics, and culture on a global scale. The digital transformation has permeated nearly every aspect of daily life, altering how we work, learn, and connect. As these technologies become increasingly vital, possessing a certain level of digital competence is no longer a luxury but an essential requirement for participation in modern society. This necessity transcends individual economic and social benefits, positioning digital literacy as a critical foundation for human development and inclusion. It underscores the emerging view that access to digital skills and technologies is not merely a privilege but a fundamental right. The concept of “digital citizenship” serves as a framework for understanding this shift. Digital citizenship moves beyond the notion of mere access to technology, emphasizing the need for individuals to engage with digital tools thoughtfully, responsibly, and critically. It embodies a multidimensional skill set, including media literacy, cybersecurity awareness, ethical online behavior, and the ability to navigate complex digital landscapes. These competencies are vital for fostering informed participation in digital spaces, promoting equity, and safeguarding individual and collective rights. From a legal and policy standpoint, this transformation brings forth complex questions about the role of governments, institutions, and private entities in ensuring equitable access to digital resources. Should digital literacy and connectivity be treated as rights akin to education or healthcare? If so, what legal frameworks are needed to guarantee these rights while addressing disparities in digital access, such as those caused by socioeconomic inequalities or geographical constraints? Recognizing digital competence as a fundamental right implies a reimagining of legal, educational, and economic policies to bridge the digital divide. Moreover, this recognition extends to global governance challenges, particularly in addressing digital inequality across nations. It calls for collaborative efforts to establish standards for universal digital inclusion, which is crucial in ensuring that technological advancements benefit humanity as a whole.
Analisis Rantai Pasok Berkelanjutan Hasil Tangkap Ikan Trasak Tpi Lekok Pasuruan Dengan Pendekatan Rapfish
Authors: Suyuti ihsan Suyuti ihsan , Ramadhan Ach Syahri
Published: February 2025

PT Heksa Artha Sakti merupakan anak perusahaan Heksa Grup, yang bertanggung jawab mendistribusikan semua produk dari Heksa Grub. Kantor distributor PT. Heksa artha sakti terdapat hampir di seluruh indonesia, Di tengah persaingan yang berat di Indonesia, PT. Heksa artha sakti mempunyai pesaing yang memiliki porsi pasar yang sangat besar juga sehingga membuat tidak stabinya penjualan selama enam bulan yang menjadi indikasi akan kebutuhan untuk melakukan evaluasi dan perbaikan manajemen pemasaran perusahaan itu sendiri.Tujuan dari penelitian ini adalah untuk menyesuaikan kriteria yang telah dirangking dan ditimbang serta membantu pengambil keputusan dengan visi dan misi perusahaan. Penelitian ini menggunakan analisis SWOT dan Analytic Network Process (ANP). pemilihan strategi perusahaan yang dipertimbangkan pada PT Heksa Artha Sakti ialah Kemampuan managemen perusahaan (0.121335), Perusahaan memiliki sarana  yang memadai (0.088277), produk berkualitas tinggi (0.111173), dan menggunakan teknologi yang kurang modern dalam memproduksi (0.081609). keempat subkriteria merupakan Karena berdasarkan hasil analisis prioritas ANP, responden memberikan prioritas tertinggi pada subkriteria tersebut. Hasil analisis prioritas ANP menunjukkan bahwa pemilihan strategi yang tepat untuk perusahaan yaitu prioritas 1 menjalin hubungan dengan customer baru , Perluasan area pemasaran dengan menggunakan teknik penjualan serta menggunakan teknologi yang ada dan melakukan pembelian bahan baku cost sedang kualitas sama memiliki bobot tertinggi berdasarkan nilai limiting yaitu 0.067936, ini membuktikan bahwa penting untuk melakukan perbaikan pada manajemen khususnya pada bidang pemasaran untuk tercapainya tujuan perusahaan.
Penilaian Risiko Postur Kerja dengan Metode Rapid Upper Limb Assessment Pemasangan Part Clip dan Wiring pada Proses Perakitan Dump Truck di PT XYZ Politeknik STMI Jakarta
Authors: Imdam Irma Agustiningsih , Salati Dianasanti , Rahmawan Nadhif , Artanto Yanuar Angkasa , Linuwih Lintang , Widiyana
Published: February 2025

Proses pemasangan clip dan wiring di lini perakitan dump truck dengan posisi postur kerja operator yang kurang nyaman, sehingga sering terjadinya keluhan akibat kelelahan.  Hal ini disebabkan karena pada saat pemasangan part operator harus membungkuk karena terhalang oleh baterai. Penelitian ini bertujuan untuk melakukan penilaian postur kerja operator pada saat proses pemasangan clip dan wiring tersebut, sehingga dapat diketahui risiko yang didapat karena kelelahan akibat kerja. Metode yang digunakan pada penelitian ini adalah metode Rapid Upper Limb Assessment (RULA).  Pada metode ini dimulai dengan menyebarkan kuesioner Nordic Body Map (NBM) untuk mengetahui keluhan bagian tubuh mana saja yang merasakan sakit dan kelelahan. Berdasarkan hasil pengukuran didapat sudut bagian upper arm sebesar 45o - 90o nilai skornya=3, bagian lower arm sudut yang terbentuk 00 – 600 skornya=2, bagian wrist membentuk sudut >15o dengan skor=2. Hasil penilaian tabel RULA berdasarkan sudut yang terbentuk untuk masing-masing bagian, yaitu bagian A skor=7, bagian B skornya 11, dan bagian C skor sebagai akhir=7 termasuk ke dalam risiko tinggi. Rekomendasi yang dapat diberikan untuk risiko tinggi adalah pengamatan dan penerapan perbaikan.
Optimalisasi Strategi Responsibilitas dalam Rantai Pasok pada CV. XYZ Furnitur untuk Meningkatkan Kepuasan Pelanggan
Authors: Dendra Feby , Vicky Agnes , Imansuri Febriza
Published: February 2025

Penelitian ini bertujuan untuk mengevaluasi strategi produksi CV. XYZ Furnitur, perusahaan yang bergerak di industri furnitur rotan di Sumatera Barat. Saat ini, perusahaan menerapkan strategi efficiency dengan memproduksi kursi tamu dalam jumlah konstan setiap periode. Namun, strategi ini menimbulkan masalah dalam memenuhi permintaan pelanggan saat terjadi lonjakan, yang berakibat pada potensi kehilangan pelanggan. Penelitian ini mengeksplorasi perubahan strategi ke arah responsive sebagai solusi untuk meningkatkan fleksibilitas dan memenuhi kebutuhan pelanggan secara lebih optimal. Metodologi yang digunakan adalah studi kasus melalui analisis rantai pasok, khususnya pada aspek produksi, inventori, dan logistik. Hasil dari penelitian menunjukkan bahwa penerapan strategi responsive mampu meningkatkan kepuasan pelanggan dan memperbaiki kinerja rantai pasok, meskipun membutuhkan pengelolaan biaya lebih cermat untuk mengatasi potensi biaya overtime dan inventori.
ANALISIS POTENSI BAHAYA UNTUK MEMINIMALISIR RISIKO KECELAKAAN KERJA PADA PROYEK PEMBANGUNAN JETTY PLTMGU LOMBOK PEAKER DI PT. XYZ MENGGUNAKAN METODE HIRARC (HAZARD IDENTIFICATION, RISK ASSESSMENT AND RISK CONTROL)
Authors: Riskawati  , Adiasa Iksan , Rahman Didi
Published: February 2025

PT. XYZ merupakan perusahaan yang bergerak dibidang kontraktor untuk pembangunan infrastruktur. Pada proses pembangunan infrastruktur ini tidak terlepas dari risiko terjadinya kecelakaan kerja. Berdasarkan hasil observasi di lapangan, ditemukannya potensi kecelakaan kerja. Penelitian ini bertujuan untuk menganalisis potensi bahaya dan memberikan usulan perbaikan untuk meminimalisir risiko kecelakaan kerja pada Proyek Pembangunan Jetty PLTMGU Lombok Peaker. Metode yang digunakan yaitu HIRARC. HIRARC digunakan untuk mengidentifikasi risiko kecelakaan kerja serta menganalisis bahaya dan memberikan usulan perbaikan untuk meminimalisir risiko yang ada. Hasil penelitian didapatkan hasil identifikasi dan terdapat 8 potensi bahaya pada pengerjaan proyek pembangunan jetty PLTMGU Lombok Peaker yaitu 25% potensi bahaya dengan level risiko rendah, 37% potensi bahaya dengan level risiko tinggi serta 38% potensi bahaya dengan level risiko ekstrim. Usulan perbaikan yang dapat diberikan pada proyek pembangunan jetty PLTMGU Lombok Peaker berdasarkan hirarki pengendalian K3 seperti pada pengikisan tanah disekitar area temporary jetty, berdiri dibawah proses pengangkatan material oleh crane dan penumpukan steel pipe dengan mengeliminasi untuk menghilangkan aktifitas diarea pengikisan tersebut. Penelitian ini diharapkan dapat meminimalisir risiko terjadinya kecelakaan kerja pada pengerjaan proyek pembangunan jetty PLTMGU Lombok Peaker.
Моделювання взаємовпливу інформаційної безпеки та обчислювальних витрат у вбудованих пристроях
Authors: Rozlomii I. , Naumenko S.
Published: February 2025

У статті запропоновано математичну модель, яка описує взаємовплив інформаційної безпеки та обчислювальних витрат у вбудованих пристроях. Вбудовані системи, такі як IoT-пристрої, медичні прилади та промислові контролери, працюють в умовах обмежених обчислювальних ресурсів, що створює значні виклики для забезпечення належного рівня інформаційної безпеки без перевантаження системи. Запропонована модель враховує ключові параметри, включаючи енергоспоживання, час обробки, обсяг пам’яті та рівень криптографічного захисту, що дозволяє дослідити баланс між безпекою та ресурсоємністю. Проведено аналіз ефективності полегшених – PRESENT, SPECK, SIMON та стандартних криптографічних алгоритмів – Blowfish, AES. Результати симуляцій, виконаних у середовищах MATLAB та Python із використанням бібліотек для тестування криптографії, демонструють, що полегшені алгоритми забезпечують значно нижчі показники енергоспоживання та часу обробки. Це робить їх оптимальним вибором для пристроїв з обмеженими ресурсами. Зокрема, алгоритми SPECK і PRESENT показали найкращі результати щодо енергоспоживання та швидкодії, тоді як AES, хоча і забезпечує високий рівень безпеки, є більш ресурсоємним. Практична значимість розробленої моделі полягає у її застосуванні для вибору оптимальних криптографічних рішень під час проектування енергоефективних вбудованих систем. Модель може бути інтегрована в процеси проектування для оптимізації безпеки та продуктивності пристроїв, що особливо важливо для IoT-архітектур, де критичним є збереження енергії та забезпечення безпеки даних
Mетод дистанційного зондування потенціалу ландшафту для побудови об'єктів малої гідроенергетики на основі геопросторових даних
Authors: Fokin A.
Published: February 2025

У статті досліджується стратегічне використання геопросторових даних у контексті розвитку малої гідроенергетики, зосереджуючись на інтеграції методів дистанційного зондування та запитів SPARQL. Зазначається, що геопросторові дані, що включають супутникові зображення, цифрові моделі рельєфу (ЦМР) і гідрологічні карти, відіграють ключову роль у визначенні оптимального розташування малих гідроелектростанцій уздовж річкових коридорів. Ці набори даних дають суттєве уявлення про характеристики рельєфу, морфологію річок, моделі землекористування та гідрологічну динаміку, полегшуючи точний вибір місця та оцінку ресурсів. Було наголошено, що методи дистанційного зондування дозволяють отримувати детальну просторову інформацію з широкої географічної області, пропонуючи цінні вхідні дані для оцінки потенційних об’єктів гідроенергетики. Супутникові зображення в поєднанні з ЦМР дозволяють точно відображати коливання висоти, межі вододілів і річкові мережі. Ці просторові дані допомагають визначити території зі сприятливими гідравлічними умовами та достатнім потоком води, що має вирішальне значення для оцінки здійсненності та енергетичного потенціалу проектів малої гідроенергетики. Паралельно запити SPARQL використовуються для отримання структурованих даних із наборів даних RDF (Resource Description Framework), що містять гідрологічну та географічну інформацію. Можливості семантичних запитів SPARQL дозволяють отримувати відповідні точки даних, такі як швидкість течії річок, дренажні зони та близькість до існуючої інфраструктури. Цей семантичний підхід підтримує процеси прийняття рішень, надаючи розуміння критеріїв придатності місця, отриманих як з даних дистанційного зондування, так і з гідрологічних вимірювань
Pengelolaan Sampah di Kelompok Wanita tani Anggrek di Tegal Mraen Sendangadi, Mlati Sleman
Authors: Titop  , Sri Handayani RW  , Titi Laras
Published: February 2025

Di lingkungan warga Masyarakat tegal maren ada sebagain yang memelihara ayam. Dalam pemeliharaan sebagain besar masih di umbar (dibiarkan berkeliaran di luar} tapi sebagain yang sudah di kendang, selain itu juga ada Masyarakat yang limbah rumah tangga belum dimanfaatakan. Pada hal jika masalah tersebut dikelola akan dapat memberikan tambahan manfaat yang lebih besar. Untuk mengatasi masalah tersebut disampaikan melalui kelompok tani Wanita Anggrek agar supaya limbah dari rumah tangga maupun pemeliharaan ayam bisa dimanfaat agar dapat meningkatkan pendapataan. Kegiatan yang dilakukan untuk mensosialisasi ini melalui penyuluhan dan juga kunjungan tempat yang sudah mengelola sampah tersebut dan berhasil.  Kegiatan tersebut mendapatkan respon yang sangat baik kepada kelompok Tani Wanita Anggrek.
Pengembangan Potensi Kebun Nanas Nusantara (SIBUNATA) Sebagai Desa Wirausaha Untuk Meningkatkan Perekonomian Masyarakat Desa Pedawang Melalui Kegiatan PPK ORMAWA 2024
Authors: Rahayu Bareza , Dwi Rani Silvia  , Saylin Nichlah  , Sekar Pramesti Wulandari  , Silvia Nurul Hikmah  , Sonia Indah Putri  , Aulia Febriyani  , Liana Syanti  , Ega Wahyu Nur  Cahyani  , Femas Aji Kurnia  , Cahya Nofita  , Asti Devi Mutiara Khoirun Nisa  , Laili  Fitriyani  , Dwi Soegiarto  , Muhammad Teguh Kuncoro
Published: February 2025

Desa Pedawang merupakan salah satu desa di Kecamatan Bae, Kabupaten Kudus, Provinsi Jawa Tengah, Indonesia Desa ini memiliki Kebun Nanas Nusantara yang dijadikan wirausaha oleh Badan Usaha Milik Desa (BUMDes) Sido Makmur Sejahtera, dan  Kelompok Sadar Wisata (Pokdarwis) Singobarong. Namun, Kebun Nanas Nusantara menghadapi masalah utama yaitu belum mencapai keuntungan atau belum profitable baik dari jasa maupun pemasaran. Kebun Nanas Nusantara menghadapi masalah utama yaitu belum mencapai keuntungan atau belum profitable baik dari jasa maupun pemasaran. Pembuatan produk olahan nanas dipilih karena ketersediaan bahan baku lokal serta adanya potensi yang dimiliki Kebun Nanas Nusantara. Tujuan utama adalah memberdayakan masyarakat desa Pedawang melalui sosialisasi, pelatihan, pendampingan usaha dan perluasan pasar lokal sehingga dapat meningkatkan pendapatan ekonomu masyarakat setempat dan kelompok sasaran.
Profound Alpha-Fetoprotein Elevation in Hepatocellular Carcinoma with Concomitant Cirrhosis: A Case Report
Authors: Fadhilaturrizqie Siregar  , Efrida
Published: February 2025

Background: Hepatocellular carcinoma (HCC) is a primary liver cancer that often arises in the setting of chronic liver disease, most commonly cirrhosis. Alpha-fetoprotein (AFP) is a tumor marker frequently elevated in HCC, but its diagnostic performance varies. We present a case of HCC with concomitant cirrhosis and a significant elevation of AFP.
Case presentation: A 30-year-old male presented with hematemesis, abdominal distension, and jaundice. He had a history of heavy alcohol consumption. Physical examination revealed anemia, icterus, hepatomegaly, and palmar erythema. Laboratory investigations showed elevated AFP (>400 IU/mL), reactive hepatitis B surface antigen (HBsAg), anemia, coagulopathy, and liver dysfunction. Imaging studies confirmed HCC and cirrhosis. This case highlights the diagnostic value of AFP in HCC, particularly when combined with clinical and imaging findings. The patient's history of alcohol abuse and HBsAg positivity are well-established risk factors for both cirrhosis and HCC. The marked elevation of AFP, along with the characteristic imaging features, strongly supported the diagnosis of HCC.
Conclusion: AFP remains a valuable tool in the diagnosis and monitoring of HCC, especially in patients with cirrhosis. However, it is essential to interpret AFP levels in conjunction with other clinical and laboratory data to ensure accurate diagnosis and timely management.
Garcinia mangostana L. Nanoextract Improves Early Inflammatory Phase Bone Fracture Healing in Diabetes Mellitus by Targeting IL-1β and TNF-α: A Comprehensive Meta-Analysis
Authors: Gregorius Gathot Garudanto  , Yuriz Bakthiar  , MI Widiastuti
Published: February 2025

Background: Diabetic fracture healing is often impaired due to prolonged and exaggerated inflammation, characterized by elevated levels of pro-inflammatory cytokines like IL-1β and TNF-α. Garcinia mangostana L. (mangosteen) has demonstrated anti-inflammatory properties, and nanoformulations may enhance its bioavailability and efficacy. This meta-analysis aimed to evaluate the effect of Garcinia mangostana L. nanoextract on IL-1β and TNF-α levels during the early inflammatory phase of fracture healing in diabetic models.
Methods: A systematic search was conducted in PubMed, Scopus, Web of Science, and Cochrane Library databases for studies published between 2013 and 2024. Studies investigating the effects of Garcinia mangostana L. nanoextracts on IL-1β and TNF-α levels in in vivo or in vitro models of diabetic fracture healing were included. Data on cytokine levels, fracture healing parameters (where available), and study characteristics were extracted. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Heterogeneity was assessed using the I² statistic.
Results: Nine studies  met the inclusion criteria. Meta-analysis revealed that Garcinia mangostana L. nanoextract significantly reduced IL-1β levels (SMD = -2.85, 95% CI: -3.97 to -1.73, p < 0.00001; I² = 88%) and TNF-α levels (SMD = -2.14, 95% CI: -3.08 to -1.20, p < 0.00001; I² = 82%) compared to control groups in diabetic fracture healing models. Subgroup analyses indicated significant reductions in both in vivo and in vitro studies.
Conclusion: This meta-analysis provides evidence that Garcinia mangostana L. nanoextract significantly reduces IL-1β and TNF-α levels during the early inflammatory phase of fracture healing in diabetic models. These findings suggest that Garcinia mangostana L. nanoextract holds therapeutic potential for improving fracture healing outcomes in individuals with diabetes mellitus.
Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis
Authors: Sasmita Dhyas Munandar Arya , Permana Kavi Gilang , Aryandono Teguh , Heriyanto Didik Setyo , Anwar Sumadi Lukman
Published: February 2025

Background: Telomere length is a potential prognostic biomarker in breast cancer, but its clinical utility remains uncertain due to inconsistent findings across the literature. This systematic review and meta-analysis aims to evaluate the association between telomere length and breast cancer survival outcomes, including overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and recurrence-free survival (RFS).
Methods: A systematic search of ten sources, including databases and publishers (JSTOR, Nature, ProQuest, PubMed, Sage Journals, ScienceDirect, Science, Scopus, Springer, and Wiley) was conducted to identify studies published up to December 31, 2023. Studies reporting associations between telomere length and survival outcomes in breast cancer patients were included. Hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CI) were extracted or calculated. Quality assessment was performed using the Newcastle-Ottawa Scale, and publication bias was evaluated using funnel plots, Egger’s, and Begg’s tests.
Results: Nine studies involving 3,145 breast cancer patients were included. Shorter telomere length was significantly associated with increased recurrence risk (DFS/RFS) (pooled HR: 1.97; 95% CI: 1.04–3.74, P = 0.039), indicating a nearly twofold increase in risk. Trends toward worse OS (pooled HR: 1.60; 95% CI: 0.90–2.86, P = 0.110) and DSS (pooled HR: 1.09; 95% CI: 0.80–1.49, P = 0.565) were observed, but did not reach statistical significance. Additionally, shorter telomere length was significantly associated with premenopausal status (pooled OR: 1.34; 95% CI: 1.06–1.70, P = 0.01).
Discussion: Shorter telomere length is associated with an increased risk of recurrence in breast cancer, highlighting its potential as a prognostic biomarker. However, further research is needed to standardize telomere length measurement methodologies and validate these findings across diverse populations and breast cancer subtypes.
Multikinase and highly selective kinase inhibitors in the neoadjuvant treatment of patients with thyroid cancer
Authors: Valerio Laura , Matrone Antonio
Published: February 2025

Multikinase inhibitors (MKIs) and highly selective tyrosine kinase inhibitors (HS-TKIs) positively impact the progression-free survival (PFS) of locally advanced and metastatic thyroid cancer cases. Moreover, disease-specific survival (DSS) and overall survival (OS) improvements were observed in some instances, suggesting a general benefit in disease control. In advanced and metastatic thyroid cancers, other conventional treatments are often ineffective when surgery cannot be performed due to the extension of the disease and/or the invasion of vital neck structures (such as the larynx, trachea, esophagus, recurrent laryngeal nerve, and carotid artery). In these cases, systemic treatments with MKIs and HS-TKIs have recently been evaluated for their potential to block tumor growth and reduce tumor size to make surgery possible or improve the control of metastatic disease. The study aimed to evaluate the performance of these systemic drugs in the neoadjuvant treatment of thyroid cancer patients, focusing on their efficacy according to the different histology.
The Effects of Regulatory Restrictions on the Financial and Credit System of Kazakhstan
Authors: Karybay Sanzhar , Zhussupov Alpysbay
Published: February 2025

The research shows the importance of constitutional regulation of the financial and credit sphere as the basis of the economic system. The purpose of the research is to pinpoint legal challenges in the realm of financial and credit regulation in Kazakhstan and propose measures to address them. The following methods were chosen for the empirical study of the major legal problems of Kazakhstan’s financial and credit system: analysis of documents and legal acts, quantitative data analysis, content analysis, regression analysis, and analysis of variance. The research revealed that the omission of critical financial and credit provisions in the constitution may result in adverse effects on economic inflation, legal framework, and national sovereignty. The negative aspects of the financial and credit sphere associated with crude oil, which led to petrocracy, are also highlighted. The authors propose a solution to a set of problematic issues that negatively affect Kazakhstan’s financial and credit sector. Particular attention is paid to issues related to Kazakhstan’s fiscal system, which tends to change very frequently. The article places particular emphasis on the regulations established by international organizations that govern financial and corporate financial matters. Notably, the enhancement of Kazakhstan's statehood through financial sovereignty emerges as a key focal point. The adoption of these measures has the potential to significantly bolster human rights, the business climate, and investment attractiveness. In the future, the specified issue may be further elucidated through a comprehensive examination of global standards’ impact on national laws, alongside the development and application of mathematical and econometric models to predict the outcomes of regulatory and legal modifications, which has the potential to enhance the strategic planning efficacy and legislative proposals execution.
СОЦІАЛЬНО-ПСИХОЛОГІЧНА ПІДТРИМКА УКРАЇНЦІВ В НІМЕЧЧИНІ: ПІДСУМКИ ДІЯЛЬНОСТІ УКРАЇНСЬКО-НІМЕЦЬКОГО БЛАГОДІЙНОГО ПРОЄКТУ
Authors: Креденцер Оксана Валеріївна
Published: February 2025

У статті представлено основні результати діяльності благодійного проєкту «Соціально-психологічна підтримка українців у Німеччині», створеного спільними зусиллями німецьких та українських фахівців із метою надання підтримки українцям, які перебувають в Німеччині внаслідок війни в Україні.Організаторами проєкту виступили німецька організація Malteser (PSU UKR 22), Інститут психології імені Г.С. Костюка НАПН України (лабораторія організаційної та соціальної психології) та Українська Асоціація організаційних психологів та психологів праці.Проєкт реалізовано з квітня 2022 р. по жовтень 2024 р. упродовж трьох етапів: підготовчого, стабілізуючого та розвивального. Кожний етап включав свої специфічні форми та напрями роботи і мав відповідні ефективні результати. Усі поставлені завдання проєкту виконано. Проєкт показав свою ефективність та високу результативність. Концепцію його діяльності може бути екстрапольовано на інші види та форми психологічних інституцій для здійснення психологічної допомоги населення в умовах різного виду соціальних криз.
Mapping the Discourse of Power: Diplomatic Actors on X (Formerly Twitter)
Authors:   Mount Kenya University, Ong’ong’a Daniel Oloo
Published: February 2025

This study explored the impact of power dynamics on digital diplomacy by analyzing the Twitter usage of three diplomatic actors (the Chinese, UK, and US Embassies in Kenya). The research aimed to answer questions about who the diplomats prioritized for engagement, how they used Twitter in crisis communication, and how they became media actors by adopting media logic in their digital diplomacy practices. The results of the study showed that Twitter was utilized by diplomats to control the daily agenda, express opinions, and influence followers and media outlets. The Chinese and UK Embassies made use of the platform for formal communication and to communicate with their diaspora. The US ambassador followed online influencers to set the online conversations and expand their online presence. Meanwhile, the UK ambassador leveraged the media to drive foreign policy and tailor messages to the Kenyan audience. The findings also indicated that all embassies had adopted a media logic by following various media sources.The study also found that the Chinese embassy was quick to respond to any tweet that mentioned human rights issues in Xinjiang, Tibet, and Inner Mongolia, and used Twitter as a tool to correct misinformation. In conclusion, diplomats use Twitter as a tool to engage with different audiences and achieve their diplomatic goals through interactive strategies such as two-way communication, storytelling, influencer engagement, hashtag campaigns, and media amplification. However, diplomats need to constructively engage with the digital public to accomplish their goals, while avoiding the risk of their messages being misconstrued.
The Interplay between PR Messaging and Loyalty in Young Adult Markets: A Study from Medan City
Authors:   LSPR Institute of Communication & Business, Widjaya Arifa Dani Anggit , Ramonita Latifa ,   LSPR Institute of Communication & Business
Published: February 2025

As public awareness of environmental and social issues grows, consumers increasingly gravitate toward brands that demonstrate a commitment to sustainability and social responsibility. This shift has prompted businesses to launch campaigns that address these concerns, effectively aligning their values with those of their target audiences. Within the beauty industry, The Body Shop’s "Be Seen Be Heard" campaign serves as a prime example, promoting environmental and social values while engaging consumers. This study examines the relationship between such public relations messaging and consumer loyalty among young adults in Medan City. A quantitative research approach was employed, with data collected from 100 respondents through structured questionnaires. Correlation analysis revealed a strong and significant positive relationship between the PR campaign and consumer loyalty, with a coefficient of 0.823. This result underscores the campaign's effectiveness in fostering loyalty within the young urban demographic by aligning brand messaging with issues of social and environmental relevance. The findings emphasize the strategic role of public relations in shaping consumer perceptions and behaviors, particularly among socially conscious young adults. They also highlight the importance of authentic, values-driven campaigns in cultivating long-term brand loyalty. This study contributes to the growing body of knowledge on the interplay between PR messaging and consumer loyalty, offering practical insights for businesses aiming to strengthen their market presence in the era of sustainability.
Re-conceptualizing Public Relations Practices in Nigeria: A Framework to Address Systemic Challenges
Authors:   Selem Consults, Eyo Nsini Anselem
Published: February 2025

This conceptual paper examines the roles and challenges of public relations practice in Nigeria by proposing a framework to address systemic issues hindering its professionalization. Despite cultural diversity shaping PR globally, the practice in Nigeria faces significant obstacles, including limited strategic involvement, deployment of unqualified practitioners, political interference, inadequate education and training, weak ethical standards, and lack of a robust regulatory framework. The absence of autonomy by the Nigerian Institute of Public Relations (NIPR) further exacerbates these issues, allowing individuals without formal training or specialization to practice, thereby undermining the profession's credibility. Using a narrative literature review, the study synthesizes existing research to identify gaps and develop a conceptual framework aimed at addressing these challenges. Drawing from role theory in public relations and Grunig’s Excellence theory, the paper proposes a tripartite framework for PR professionalization in Nigeria. This framework emphasizes education to impart theoretical knowledge and practical skills, accreditation to ensure eligibility for membership and registration, and certification to uphold ethical standards and professional conduct as well as autonomy of the NIPR as the primary regulatory body of the procession in the country. By implementing this tripartite model, PR practitioners in Nigeria can be empowered to perform strategic managerial and operational communication roles effectively. This will enable practitioners and by extension NIPR to uphold the integrity of the profession, and foster standardization and professionalization in alignment with global best practices. Hence, this study provides actionable insights for re-conceptualizing PR in Nigeria, advancing its role as a credible and strategic profession.
On the development of the code of practice "Concrete and reinforced concrete structures of transport facilities, tunnels, and metro systems. Repair regulations"
Authors: Shilin Andrey A. , Shchukina Anastasia B.
Published: February 2025

Introduction. Transport tunnels and metro systems are complex engineering structures subjected to significant loads and diverse environmental impacts, necessitating a systematic approach to ensuring their operational reliability. Concrete and reinforced concrete structures, which form the backbone of these facilities, frequently experience damage that compromises their functional characteristics and safety. The need to update and systematize approaches to repairing of such structures has become urgent due to updating of the regulatory framework, increasing demands for infrastructure resilience, and the adoption of advanced technologies.

The aim of developing the draft Code of Practice is to establish the technical foundations for designing, organizing, and conducting of the repair and restoration work on concrete and reinforced concrete structures of transport tunnels and metro systems. This applies to structures under construction, in operation, or temporarily taken out of service, which are subject to constant exposure to water and water vapor, loads, and impacts from surrounding rock masses. The work also considers the possibility of restoration being limited to the internal contour of the lining or the structural elements of subsurface sections.

Materials and methods. As part of the work, an analysis of existing regulatory documents in the field of repair of concrete and reinforced concrete structures was carried out, along with the review of provisions and recommendations of international organizations. Additionally, the results of research and development (R&D) were studied and taken into account.

Results. The result of the work is a Draft Code of Practice that includes key provisions for the design, organization, and implementation of repair works, including methods for restoration, reinforcement, and sealing of the structures. The project incorporates modern repair technologies and takes into account the operational specifics of underground transport facilities. The document has undergone a stage of public discussion, received expert evaluations from professional communities and authorities, and is being prepared for approval and implementation.

Conclusions. The implementation of the Code of Practice will enhance the quality and reliability of repair works, reduce costs, and extend the intervals between repairs, thereby contributing to the sustainable development of transport infrastructure.
Enhancing Building Technology Education through the Integration of Virtual Reality
Authors: Onatere-Ubrurhe Joyce Ogheneruona , Chinyio Ezekiel , Georgakis Panagiotis
Published: February 2025

This study investigated the role of Virtual Reality (VR) in enhancing building technology education across Nigerian tertiary institutions. Data were gathered from 162 respondents, including Educators and Students, via a survey. Descriptive and inferential statistics revealed moderate familiarity and limited institutional adoption of VR (mean = 2.29). However, the respondents demonstrated a strong awareness of its potential benefits (mean = 3.64) and relevance in bridging practical skill gaps (mean = 4.46). Notable challenges of utilizing VR included inadequate infrastructure, financial constraints, and limited training opportunities, corroborating global and local findings. Despite these barriers, VR was perceived as highly effective in improving student engagement (mean = 4.67) and practical skill development (mean = 4.72). Statistical analyses confirmed significant differences in perceptions between educators and students regarding familiarity and challenges (p < 0.05). The study emphasizes the need for strategic investments and curriculum restructuring to harness VR’s potential in addressing skill gaps in Nigeria’s building technology education, while proposing an implementation strategy for integrating VR into curricula, which includes developing VR modules that align with educational objectives, investing in necessary technology and infrastructure, and providing comprehensive training for educators. This research furnishes valuable perspectives on leveraging VR to enhance building technology education, with the ultimate objective of enhancing educational accomplishments and better equipping students for careers in the field.
Implementación de Internet Satelital en Zonas Rurales de la Ciudad de Manta, para la continuidad de las Clases Virtuales durante el año 2021
Authors: Espinoza García Diego Leonardo
Published: February 2025

El proyecto de implementación de internet satelital en zonas rurales de la ciudad de Manta, específicamente en la comunidad de Lígüiqui, durante el año 2021, abordó la urgente necesidad de garantizar la continuidad de las clases virtuales en un contexto de desigualdad tecnológica exacerbada por la pandemia de COVID-19. Esta iniciativa surgió como respuesta a las profundas brechas de conectividad que afectaban a estudiantes de áreas rurales, donde apenas el 7% de los hogares tenía acceso limitado a internet y menos del 2% contaba con dispositivos funcionales de conectividad para el aprendizaje virtual. Mediante un diagnóstico inicial de las necesidades tecnológicas, el proyecto identificó estrategias específicas, entre ellas la implementación de antenas satelitales y programas de capacitación tecnológica para estudiantes, docentes y familias. La instalación del sistema permitió conectar al 85% de los hogares de la comunidad, asegurando el acceso consistente a las clases virtuales. Además, la formación ofrecida redujo significativamente el porcentaje de beneficiarios sin conocimientos básicos en el uso de plataformas digitales, pasando del 70% al 15%, lo que fortaleció sus competencias tecnológicas y empoderó a la comunidad para afrontar desafíos educativos futuros. El proyecto, con un costo estimado de $20,000, demostró ser una solución viable y efectiva para mitigar las desigualdades educativas en contextos rurales, estableciendo una base tecnológica que atendió las necesidades inmediatas, fomentando un desarrollo comunitario sostenible y equitativo.
Four new species of Erioscyphella (Leotiomycetes, Helotiales) from southwestern China
Authors: Luo Le , Thilini Chethana Kandawatte W. , Zhao Qi , Su Hong-Li , Li Cui-Jin-Yi , Thiyagaraja Vinodhini , Al-Otibi Fatimah , Hyde Kevin D.
Published: February 2025

Erioscyphella is found across various regions and is part of the family Lachnaceae (Helotiales). It is distinguished by its white to orange disc-shaped apothecia, white to brown receptacles, and granulated hairs that contain amorphous or resinous material. These hairs lack swelling apices and crystals. Additionally, this genus is unique for its long ascospores. In the present study, we collected eight specimens from southwestern China. Morphological and phylogenetic analyses based on the combined LSU, ITS, mtSSU and RPB2 dataset showed that our specimens represent four new species of Erioscyphella, including E. ailaoensis, E. baimana, E. gelangheica and E. tengyueica. Here, we provide complete morphological descriptions with illustrations and sequence data essential for future taxonomic and evolutionary research.
Assessing the suitability of two-group cross-sections and diffusion coefficients derived from SERPENT-2 for small modular reactor ACP-100
Authors: Ishraq Md. Abidur Rahman , Kruglikov Anton Evgenivich
Published: February 2025

The focus of this work is to analyse the suitability of two-group diffusion coefficients and macro constants generated from SERPENT using out-scattering approximation (OSA), transport correction (TRC) and cumulative migration methods (CMM) for fuel and non-fuel materials. For this purpose, various assembly and core models of ACP-100 SMR were designed. Assessment of these constants was conducted using COMSOL Multiphysics. For six distinct fuels, the best models were proposed with the least error margin in keff. Fuel material affects the group constants of non-fuel components except for radial reflectors. The sufficiency of two-group calculation was justified through spectrum analysis. Additional analysis revealed that MOX-RG has the hardest spectrum among all the fuels. Moreover, the effectiveness of boric acid to control excess reactivity was observed. Subcriticality was achieved for all fuel types except MOX-RG at a boric acid concentration of 4500 ppm. The influence of variation of boric acid concentrations on group constants was investigated using TRC and OSA. The reactivity difference between SERPENT and COMSOL was determined. It was found that OSA generates the most accurate results for MOX-RG with maximum 863 pcm error, while TRC produces higher accuracy with maximum error of approximately 250 pcm for other fuels.
Tungsten wires with steel matrix composite: wetting and infiltration by steel melt
Authors: Popov Nikita , Suchkov Alexey , Zharkov Mikhail , Kirillova Veronika , Bazhenov Alexander , Dzhumaev Pavel , Vertkov Alexey , Sevryukov Oleg
Published: February 2025

Lithium-based capillary porous systems (CPS) made of tungsten mesh are a part of the most prospective approach to plasma facing components. Currently, tungsten mesh as a part of the CPS is mounted directly on the experimental assembly without a proper joining with a substrate. Tungsten mesh filled with steel could be used as a base structure for the CPS. The experiment considers the wetting of tungsten by steel melt and the features of short- and long-term interaction between the two materials. Wetting was studied by improved sessile drop experiment. The results show that an average contact angle is 69° for SS316LN and 83.2° for SS420 melt on tungsten substrate with a temperature of 500–650 °C. Tungsten-steel composite was manufactured by infiltration of tungsten mesh with a steel melt. As a result of an active dissolution of tungsten in steel melt, (Fe,Cr)7W6 interaction layer with a thickness up to 10 µm forms around tungsten. Optimal structure with the thinnest intermetallic layer is obtained in the zones with the lowest temperature and the highest cooling speed.