bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of the Cytotoxicity of Fig, Lemon, Olive, and Turnip Exosomes on MCF-7 Cells
Authors: KARAOSMANOĞLU Oğuzhan
Published: October 2019

With their nano-sized structure, exosomes are involved
in a wide variety of cellular processes such as genetic information flow,
immune system modulations, intercellular communication, and pathophysiological
changes. The use of exosomes are exponentially growing particularly in the
areas of identification of biomarkers, development of nanocarriers for
effective drug delivery, and vaccine production. In recent years, edible plant
derived exosomes gained much interest with their strong antimicrobial
activities, modulatory activities on the intestinal stem cells, and the
anticancer activities. In this study, the cytotoxic effects of fig, lemon, olive and turnip derived
exosomes were investigated through the neutral red uptake assay. It was
observed that 100 µg/mL protein containing lemon and turnip derived exosomes
inhibited the cell proliferation significantly, on the other hand, fig and
olive derived exosomes did not alter the proliferation of MCF-7 cells. Since
the results for the cytotoxic activity of turnip exosomes are original in this
research, it was found worthy to emphasis the utility of turnip exosomes for
the development of new anticancer agents or new drug delivery nanocarriers.
Path Analysis of the Relationship Between Weaning Weight and Some Morphological Traits in Awassi Lamb
Authors: GÜL Sabri , KESKİN Mahmut , GÜZEY Yusuf Ziya , BEHREM Sedat , GÜNDÜZ Zühal
Published: October 2019

In this
study, Path analysis was used to determine the direct and indirect effects of
some morphological traits such as wither height, sacrum height, body length,
chest depth, chest girth and chest width on the weaning weight of sheep. The
data was obtained from 200 heads of Awassi lambs raised in Gaziantep province.
The results of the path analysis indicated that the variants of sacrum height
and body length sustained the most significant effect on the weaning weight.
Consequentely, chest girth and body length were the most favorable measurements
to estimate weaning weight in Awassi and could be used as a reliable criteria
for practical selection in Awassi lambs.
Estrés laboral en trabajadores con alto riesgo intralaboral en una institución hospitalaria nivel 3 de Buga, Colombia
Authors: Martínez-Espinosa Olga M , Devia- Belalcazar Leidy J , Quenguán-Quenguán Luz M
Published: October 2019

Objetivo: Determinar la prevalencia del estrés en trabajadores de una Institución Prestadora de Servicios de Salud nivel 3, identificados previamente como población en alto riesgo.

Metodología: Estudio descriptivo, correlacional, de corte transversal, realizado en 65 trabajadores de las áreas médica y administrativa en una empresa de salud de tercer nivel de Buga, Colombia. Se aplicó un cuestionario validado por el gobierno colombiano para la evaluación del estrés para tal fin. Se exploró la correlación entre el estrés y factores intralaborales asociados con riesgo alto y estrés.

Resultados: Se identificaron altos niveles fisiológicos de estrés en el 10,5% de los jefes profesionales y técnicos; no obstante, predominaron los niveles de riesgo bajos y muy bajos al evaluar específicamente síntomas comportamentales, intelectuales o psicoemocionales. Entre auxiliares y operarios, el 15,2% mostró síntomas fisiológicos asociados con riesgo alto, alcanzando en un 2,2% un nivel muy alto. Con respecto a los factores de riesgo debidos a factores psicosociales intralaborales, la totalidad de los participantes habían sido clasificados como en alto riesgo según un estudio realizado por la IPS en el año 2012.

Conclusiones: Los resultados de este estudio no muestran tendencias significativas vinculantes o causales, indicando que los factores de alto riesgo psicosocial no son determinantes de una alta prevalencia de estrés en estos trabajadores.
Agroquímicos y afectaciones a la salud de trabajadores agrícolas: Una revisión sistemática
Authors: Vásquez Venegas Carmen E , León Cortés Silvia G , González Baltazar Raquel
Published: October 2019

Los agroquímicos han venido causando una serie de efectos a la salud de las personas y especial en los trabajadores que se encuentran laborando con este tipo de sustancias, el contacto a largo plazo puede ocasionar enfermedades de origen crónico a nivel de algunos órganos y sistemas.

Objetivo: Realizar una revisión sistemática de la literatura disponible al momento sobre esta temática.

Metodología: Se lo realizo mediante la búsqueda de artículos publicados en revistas científicas desde el año 2005, en especial aquellos que hacen referencia al daño del sistema nervioso y la población estudiada sea trabajadores agrícolas que se laboren en plantas agrícolas o productoras de fitosanitarios, se indagó acerca de los métodos que usaron para el diagnóstico y el tipo de síntomas encontrados.

Resultados: El objetivo principal de los profesionales que se dedican a la investigación de daños a la salud es no solo buscar los síntomas sino que se establezcan políticas, programas que ayuden con la prevención de enfermedades en especial aquellas derivadas del trabajo.

Conclusión: Toda investigación científica que ayude al diagnóstico temprano de enfermedades derivadas del trabajo, como también promocione la implantación de medidas preventivas ayudará el mejoramiento de la calidad de vida del trabajador
La gestión de la seguridad basada en los comportamientos. ¿un proceso que funciona?
Authors: Martínez-Oropesa Ciro
Published: October 2019

El proceso de gestión de la seguridad basada en los comportamientos (PGSBC),

Objetivo: Brindar un marco referencial resumido sobre la gestión de la seguridad basada en los comportamientos y aportar datos y fundamentos que permiten resaltar los beneficios e impactos para las empresas. Se realizaron revisiones de una importante información publicada.

Metodología: se basa en el desarrollo de observaciones a las personas en el cumplimiento de las tareas y retroalimentación de información y reforzamiento positivo en tiempo real.

Conclusión: Con el propósito de eliminar los comportamientos a riesgos observados, así como, en algunos de los casos más avanzados, modificar los factores ambientales y organizativos que los originan. 

Resultados: De esta reflexión se deducen y resumen cambios e impactos positivos en la gestión de la seguridad en muchas empresas en las últimas décadas, basada en indicadores proactivos y reactivos de la Seguridad Industrial.
Sistemas de gestión
Authors: Leal Terranova Oscar Eduardo
Published: October 2019

Los sistemas de gestión de seguridad y salud en el trabajo (SG-SST) tienen por objeto proporcionar un método para evaluar y mejorar los resultados en la prevención de los incidentes y accidentes por medio de la gestión eficaz de los peligros y riesgos en el lugar de trabajo. Es un método lógico y secuencial para decidir aquello que debe hacerse, y el mejor modo de hacerlo, supervisar los progresos realizados con respecto al logro de las metas establecidas, evaluar la eficacia de las medidas adoptadas e identificar ámbitos que deben mejorarse. Puede y debe ser capaz de adaptarse a los cambios en la actividad de la organización y a los requisitos legislativos.1 El SG-SST genera impacto positivo en la prevención de enfermedades laborales, promueve ambientes sanos de trabajo y disminuye costos potenciales generados por accidentes, adicional, promueve la cultura de la seguridad y el mejoramiento continuo en los diferentes niveles de la organización, estos sistemas de gestión se consideran como unas de las herramientas más importantes para la gestión efectiva del nivel de riesgo laboral en las organizaciones, la prevención de la enfermedad y el mejoramiento de la calidad de vida de la población trabajadora.
Reducción de accidentalidad en manos con el ciclo PHVA
Authors: Arias-Moreno Patricia , Gómez-Vélez Diego F , Leal-Terranova Oscar E
Published: October 2019

Objetivo: Compartir la experiencia de implementación de metodología PHVA en reducción de accidentalidad en manos, en una empresa del sector agroindustrial del Valle del Cauca, Colombia.

Metodología: Se describieron las actividades realizadas para reducir accidentalidad en manos, enmarcadas en el ciclo PHVA (Planear, Hacer, Verificar, Actuar).

Resultados: Se evidenció reducción de accidentalidad en manos en un 68,3% y la severidad de los mismos representada en días de ausentismo en un 82,3%.

Conclusiones: con la implementación de una campaña basada en concientizar y comprometer a los colaboradores con el autocuidado de las manos y asegurar el cierre de condiciones peligrosas que pueden generar accidentes, se realiza intervención efectiva para la prevención de accidentes en manos.
Factores de riesgo, evaluación, control y prevención en el levantamiento y transporte manual de cargas.
Authors: Caicedo Angélica , Manzano Jorge , Gómez-Vélez Diego Fernando , Gómez Lessby
Published: October 2019

El levantamiento y transporte manual de cargas se asocia a los desórdenes músculo esqueléticos, los cuales representan un alto costo para los sistemas de salud y las empresas. Por tanto se requieren estrategias que mitiguen o eliminen los riesgos derivados por su ejecución.

Objetivo: Revisar conceptos actualizados sobre los factores de riesgo, métodos de evaluación, medidas de control y prevención que se asocian al levantamiento y transporte manual de cargas.

Metodología: Se revisaron artículos publicados de 2007 - 2013 en las bases de datos EBSCO, PROQUEST Y SCIENCE sobre factores de riesgo, métodos de evaluación, medidas de control y prevención asociadas al levantamiento y transporte manual de cargas.

Resultados: Se revisaron 43 artículos, donde se encontró que los factores de riesgos asociados fueron la magnitud de la carga, la altura de la superficie, la frecuencia y el ritmo del levantamiento. Las metodologías de evaluación más usadas fueron el método NIOSH y los análisis de videos a través de software. Las medidas de control y prevención estuvieron relacionadas en su mayoría con el control en los individuos, de las cuales el dispositivo asistencial de levantamiento personal (PLAD) fue el más citado para controlar los riesgos.

Conclusiones: El levantamiento de carga constituye un importante factor de riesgo biomecánico en la empresa. Entre las medidas de control y prevención de lesiones en la manipulación manual de cargas, tienen relevancia los controles en el trabajador.
Alteraciones espirométricas por exposición a material particulado
Authors: Téllez Ingrid , Lozano Nini , Restrepo-Osorio Hernando , Carvajal Reynaldo
Published: October 2019

En el área laboral la espirometría es una prueba de tamizaje que permite determinar la función pulmonar de trabajadores expuestos a agentes contaminantes y proporciona información necesaria para tomar medidas de prevención y protección respiratoria evitando así efectos negativos para la salud de los trabajadores.

Objetivo: Identificar las alteraciones espirométricas en trabajadores expuestos a material particulado inorgánico en una empresa de construcción durante el 2013.

Metodología: Estudio observacional, descriptivo de corte transversal, realizado en 199 registros de trabajadores. Se recolectaron datos mediante encuesta de caracterización socio-demográfica y cuestionario epidemiológico.

Resultados: Los datos se analizaron mediante los programas estadístico Microsoft Excel 2010 y SPSS versión 20. Las variables numéricas se describieron con base en medidas de tendencia central y variabilidad, con base en porcentajes y distribuciones porcentuales. Para examinar asociaciones se utilizaron pruebas de significancia estadística con el coeficiente de Pearson (valor P= 0.05) Resultados: Se encontraron alteraciones espirométricas de diferente índole en un 23% de la población. Los cambios a nivel de las variables espirométricas se evidenciaron en alteraciones de la CVF y la relación VEF1/CVF.

Conclusión: La espirometría es un buen instrumento para los exámenes periódicos ocupacionales para detectar alteraciones del sistema respiratorio en trabajadores expuestos a material particulado inorgánico, sin embargo la espirometría por sí sola no proporciona suficiente valor para diagnosticar la enfermedad respiratoria ocupacional teniendo en cuenta que variables sociodemográficas como la edad entre otras influyen en la capacidad pulmonar
Capacidad de trabajo y condiciones laborales y demográficas en auditores mexicanos de sistemas de gestión de la calidad
Authors: López-Hernández Enrique
Published: October 2019

Estimar la asociación entre la capacidad de trabajo y las condiciones socio laborales y demográficas de los evaluadores mexicanos de la conformidad, en 2014.Métodos: Estudio exploratorio, transversal y analítico en una muestra de 90 individuos. Se aplicaron dos instrumentos: Índice de Capacidad de Trabajo y un Cuestionario Sociolaboral y Demográfico. Se utilizaron los estadísticos de asociación bivariada y regresión logística binomial.Resultados: Estuvieron incluidas 48 mujeres y 42 hombres, de 18 a 73 años de edad, promedio de 40.35 (± 12.277). La escolaridad fue mayormente licenciatura, siguiéndole la de nivel medio superior y la de maestría. Fue más prevalentes el número de auditores con pareja estable, los que tuvieron hasta 2 hijos, y hasta 2 dependientes económicos. Hubo asociación significativa entre la capacidad para el trabajo y la edad, número de hijos y antigüedad en el puesto.Conclusiones: De las categorías de capacidad para el trabajo: pobre, moderada, buena y excelente; la primera no figuró entre los hallazgos. La más prevalente fue la de buena. Con más de 2 años de antigüedad en el puesto, existe un 87.6% menor probabilidad de llegar a tener buena capacidad para el trabajo. Con hasta 50 años de edad existe un 96.2% menor probabilidad de llegar a capacidad excelente y buena de trabajo. Y con hasta 8 horas trabajadas por día, existen 7.8 veces mayor probabilidad de no llegar a capacidad buena y excelente de trabajo.
La teoría del consenso cultural y el construccionismo social
Authors: Aurioles-Tapia Irving M , Torres-López Teresa M
Published: October 2019

Desde la industrialización del trabajo, hasta nuestros días, la cultura de seguridad ha sido un factor determinante para las organizaciones a nivel global, concepto definido como el conjunto de creencias, normas, actitudes, roles y prácticas socio-técnicas que se ocupan de reducir al mínimo la exposición de los empleados, directivos, clientes y miembros del público a condiciones consideradas peligrosas o perjudiciales. El enfoque cultural en seguridad y salud en las últimas décadas ha sido el identificar y modelar dicha cultura desde un paradigma explicativo.

Objetivo: Interpretar la antropología cognitiva y el construccionismo social, ofrecen otra óptica para poder interpretar dicha cultura y una visión más objetiva de cómo éste concepto es llevado a cabo desde el interior de las organizaciones y así, lograr entender que limitaciones tienen los actuales modelos culturales para la gestión de la seguridad y salud ocupacional. La teoría del consenso cultural estima las respuestas culturalmente apropiadas o correctas a las preguntas y diferencias individuales en el conocimiento cultural de cada individuo y el construccionismo social se considera como un procedimiento mediante el cual se estudia la selección histórico-social de los contenidos ideacionales, sobrentendiéndose que los contenidos mismos son independientes de la causalidad histórico-social, por consiguiente inaccesibles al análisis sociológico

Conclusiones: Al partir de los supuestos anteriores, es factible entonces el poder analizar el concepto cultural en seguridad y salud ocupacional mediante las concepciones culturales de los trabajadores en cualquier tipo de organización.
Trabajadores expuestos a solventes y daños a la salud: una revisión sistemática
Authors: Sánchez Pinto Boris , León Lilia Prado , León Cortés Silvia , González Baltazar Raquel
Published: October 2019

A nivel mundial se utilizan miles de substancias químicas en múltiples industrias, de las cuales más de 800 son neurotóxicas, considerando que los potenciales efectos provocados por ellas no son fácilmente identificables, y pueden alterar la calidad de vida de la persona, adicionalmente en varios países no se realiza un adecuado programa preventivo frente a este factor de riesgo laboral.

Objetivo: Efectuar una revisión de artículos relevantes relacionados a la exposición de trabajadores a solventes orgánicos.

Conclusión: La exposición a solventes orgánicos en general y especialmente a varios de ellos, tales como tolueno, xileno y benceno afectan negativamente la salud del trabajador que se encuentra expuesto a este tipo de substancias químicas, y esos efectos se pueden presentar de una forma no evidente por el tipo de exposición a bajas dosis pero de manera permanente, crónica, lo que dificulta la identificación de síntomas y posterior diagnóstico.
AS MULHERES E A VIOLÊNCIA DE GÊNERO NO BRASIL
Authors: Andrade Ritz Claudia Danielle
Published: October 2019

No Brasil, as Leis 11.340/2006 (Maria da Penha), 13.104/2015 (Feminicídio) e 13.718/2018 (Importunação Sexual) buscam coibir ações violadoras contra as mulheres. Não obstante, os índices de violência contra mulheres no Brasil continuam alarmantes. Por isso, objetivamos uma reflexão que considere a violência, as relações de gênero e o perfil nacional predominantemente cristão, a partir dos aspectos sociorreligiosos e jurídicos presentes na violência contra as mulheres. Nossa metodologia compreende referencial bibliográfico, dados estatísticos contidos no Mapa da Violência 2015, no CENSO religioso 2010 e a legislação vigente.
UMA PIETÀ BRASILEIRA: A ESCULTURA DE NOSSA SENHORA DA PIEDADE EM CAETÉ, MINAS GERAIS
Authors: Dias Michele Dos Santos , Kirchner Renato
Published: October 2019

O presente artigo tem como objetivo apresentar a escultura de Nossa Senhora da Piedade localizada em Caeté, MG, sua origem e contexto histórico. Para isso, será apresentada a conjuntura em que foi produzida a escultura, tema de inspiração da obra, estilo artístico e a importância no campo religioso deste importante Patrimônio Histórico e Artístico tombado pelo IPHAN. Para atingir este objetivo, serão tomados como base dois importantes estudos sobre a obra e o santuário: "A Serra e o Santuário Nossa Senhora da Piedade: uma herança setecentista das Minas do Ouro", de José Carlos Vargens Tambasco e "O Aleijadinho na Serra da Piedade", de Edmundo Fontenelle.
SENSO RELIGIOSO EM TRANSFORMAÇÃO NAS PERIFERIAS DAS GRANDES CIDADES
Authors: Senra Flávio , Leite Bruna Thamires da Silva
Published: October 2019

Este artigo apresenta uma reflexão sobre o senso religioso em transformação nas periferias das grandes cidades através de um estudo de caso na Avenida Nova York, no Bairro Capelinha – Betim/MG. O trabalho aqui apresentado procura identificar os elementos responsáveis pelo processo de aglomeração de templos na referida avenida. O suporte teórico da pesquisa abordou as contribuições da Geografia Urbana, uma caracterização geral sobre o pentecostalismo no processo de metropolização, além de aspectos concernentes à localização e às funções urbanas. Os resultados apontaram a existência de elementos que contribuíram para o surgimento da aglomeração de igrejas pentecostais na região. Destacam-se, neste caso, o papel de atração e expulsão que a Região Metropolitana de Belo Horizonte (RMBH) exerce, a fragilidade socioeconômica da população do bairro, a ausência da Igreja Católica, e, por fim, a lógica de instalação das igrejas pentecostais.
A CONFERÊNCIA DE MEDELLÍN E A TEOLOGIA DO LAICATO. UMA LUZ PARA OS DIAS DE HOJE!
Authors: Ottaviani Edelcio , Frezzato Anderson
Published: October 2019

Este artigo visa apresentar a Conferência de Medellín como continuidade das assertivas do Concílio Vaticano II a respeito da Teologia do Laicato. O Vaticano II elaborou uma sólida teologia do laicato fundamentada na eclesiologia que entende a Igreja como Povo de Deus. Todo trabalho conciliar está inserido na história e na dinâmica da construção do pensamento teológico, o que requer recepção e atualização, especialmente frente à vida dos povos, e aqui, em questão, dos povos latino-americanos. É nesse horizonte que a Conferência de Medellín se caracteriza por ser um esforço do Magistério das Igrejas Particulares, reunidas pelo CELAM, em desenvolver uma a teologia do laicato herdada do Concílio e adaptada à realidade sofrida latino-americana, na qual são sublinhados o compromisso social, testemunho e apostolado.
O ENSINO RELIGIOSO E A BNCC: POSSIBILIDADES DE SE EDUCAR PARA A PAZ
Authors: Da Costa Ferreira Renan , Brandenburg Laude Erandi
Published: October 2019

O Ensino Religioso, a partir da Base Nacional Comum Curricular (BNCC), passa a se constituir como uma área do conhecimento. Assim como as demais áreas do conhecimento, possui objetivos, habilidades e competências que precisam ser consolidadas durante o processo formativo dos estudantes. Os objetivos propostos pela Base Nacional Comum Curricular convergem para uma educação pautada na paz, pois fundamentam-se na valorização dos Direitos Humanos, no diálogo, na alteridade e no reconhecimento das diferentes identidades. Contudo, para se educar para paz é necessário muito mais do que objetivos, habilidades e competências. Antes de tudo é necessário que o Estado possibilite meios para que tudo possa acontecer, em primazia, a formação docente para atuar no Ensino Religioso. Também são necessárias proposições pedagógicas para implementação dos pressupostos de uma cultura da paz e para a paz.
CUIDAR, BRINCAR E EDUCAR NA EDUCAÇÃO INFANTIL: EDUCAÇÃO PARA A PAZ - APRENDER A RESPEITAR A DIVERSIDADE
Authors: Ulrich Claudete Beise , Grasselli Martinélia Rodrigues de Almeida
Published: October 2019

A educação infantil está pedagogicamente fundamentada na mediação entre cuidar, brincar e educar. É a partir das crianças que se constrói o fazer pedagógico na educação infantil. O brincar das crianças revela muito de sua realidade social e religiosa, envolta também por agressões e violências. O presente artigo reflete sobre a criança como sujeito histórico de direitos, conforme o Estatuto da Criança e do Adolescente. No aprender a respeitar a diversidade está se educando para a paz. A educação para a paz necessita envolver toda a comunidade escolar. Afirma-se que a construção da paz é um processo e necessita ser coletiva, alegre e colorida. Cita-se como exemplo de um projeto interdisciplinar a pintura do muro do Centro de Educação Infantil João Pedro de Aguiar, em Vitória-ES. O presente artigo está fundamentado em Marques, Wachs, Freire, Kramer, Candau, Grasselli, Estatuto da Criança e do Adolescente e documentos nacionais que afirmam a importância da educação para a paz.
Obostrzenie wymiaru kary w prawie kanonicznym oraz polskim prawie karnym
Authors: Smoluchowska Agnieszka
Published: October 2019

Ustawodawca kościelny w kan. 1326 § 1 i 2 KPK/83 zawarł okoliczności, które wprawdzie fakultatywnie, ale jednak mogą skutkować surowszym ukaraniem przestępcy. Uregulowania, przewidujące obostrzenie wymiaru kary przewidział również ustawodawca świecki w art. 64 § 1 i 2, art. 65 § 1, art. 57a § 1 i 2 oraz art. 91 § 1, 2 i 3 Kodeksu karnego. Systemy te nie funkcjonują jednak w próżni. Odnoszą się do konkretnych podmiotów, które są jednocześnie wiernymi Kościoła katolickiego i obywatelami Rzeczypospolitej Polskiej. Niniejszy artykuł ma na celu scharakteryzowanie instytucji obostrzających wymiar kary oraz wskazanie podobieństw i różnic pomiędzy tymi systemami. Prawo kanoniczne i świeckie zawierają systematyczne uregulowania podobne dla nich obu (jak ma to miejsce w przypadku recydywy), jak i je różniące, których jest więcej. Głównym powodem takiego stanu rzeczy jest to, że prawo karne jest prawem o wysokim stopniu abstrakcji, bowiem jest skierowane do wszystkich obywateli Rzeczypospolitej Polskiej, a także osób przebywających na jej terenie. Jego celem jest ukaranie sprawcy w sposób zgodny z oczekiwaniami społeczeństwa oraz prewencja generalna i ogólna. W przypadku prawa kanonicznego odnosi się ono do konkretnych podmiotów będących wiernymi Kościoła katolickiego. Ponadto kieruje się ono zasadą miłosierdzia kościelnego wymiaru kary zawartą w kan. 1349 KPK/83.
KRAS and NRAS Mutations in Moroccan Patients with Colorectal Cancer
Authors: H Dehbi , OK Ait boujmia , S Benayad , HH El Idrissi , M Karkouri
Published: October 2019

Objective: Activating mutations in the RAS proto-oncogene (KRAS, HRAS and NRAS) play a crucial role in carcinogenesis and drug resistance in many cancers including, colorectal cancer. The aim of the present study was to evaluate the frequencies of KRAS and NRAS oncogenic mutations in Moroccan CRC patients.Patients and methods: In the present study, formalin-fixed paraffin-embedded CRC specimens from 114 Moroccan CRC patients were analyzed. To detect mutations in codons 12, 13 and 61 of the KRAS and NRAS genes, the pyrosequencing technique was used.Results: 114 colorectal cancer patients were included in this study, 64 were males and 50 were females, the primary tumor was the most frequent type (78.1%) and the commonest histological type was ADK (77.2%). KRAS mutation was found in 49 of all CRC patients and the most frequent KRAS mutations were 35G>T, 35G>A and 38G>A. On the other hand NRAS mutation was detected only in 6 patients. No statistically significant relationship between CRC patient’s characteristics and RAS mutations was found.Conclusion: Our results suggest that the KRAS mutation is more frequent among Moroccan patients with CRC, which is in agreement with the most previous studies. Further studies, with a larger number of CRC patients, are needed to confirm our findings.
Phenotypic Polymorphism of Normal Rat Liver Kupffer Cells
Authors: El'chaninov A. V. , Lokhonina A. V. , Makarov A. V. , Vishnyakova P. A. , Kananykhina E. Yu. , Nikitina M. P. , Grinberg M. V. , Bykov A. V. , Charyeva I. G. , Bol'shakova G. B. , Fatkhudinov T. Kh.
Published: October 2019

The aim of study was to evaluate the immunophenotype of resident macrophages of the liver, Kupffer cells, in rats in the norm.

Material and methods. The study included male Wistar rats’ samples (n=6) that presented fragments of the middle lobe of the liver taken under ether anesthesia. The obtained samples were fixed in liquid nitrogen, after that cryosections 5–7 μm thick were prepared. Histological slides were used to detect the expression of a number of macrophage markers with an antibody kit: CD68, CD206, CD 163, CD86. After the first antibodies, sections were stained with antibodies conjugated to FITC, cell nuclei were detected using DAPI, the obtained preparations were studied using a fluorescence microscope.

Results. When analyzing the expression of CD68 in the rat liver, it was found that normally about 20% of the cells in the field of vision appeared to be CD68+ cells, which was consistent with the earlier study results of the authors. The number of CD163+ and CD206+ cells coincided with the number of CD68+ macrophages, while CD86+ macrophages were significantly less.

Conclusions. Under normal conditions, the population of resident macrophages of the rat liver is represented by cells with pronounced expression of CD68, CD163 and CD206. A large number of CD163+ and CD206+ macrophages allows concluding that Kupffer cells are close to the M2 pro-regenerative phenotype. However, the detection of CD86+ resident macrophages indicates the presence of M1 macrophages, or the presence of normal macrophages with an intermediate M1 and M2 phenotype, in the rat liver. The revealed high content of macrophages expressing CD163 and CD206 in the liver evidences not only pro-regenerative properties of Kupffer cells, but also the close connection of macrophages with liver functions, since these receptors are involved in the utilization of hemoglobin and a number of hormones.
The Inﬂuence of Halal Labelization, Brand Image and Product Quality Towards Consumer Purchase Decisions of Wardah Cosmetic Product
Authors: . Sumartik , Indayani Lilik , jannah Zahratul
Published: October 2019

The purpose of this study was to ﬁnd out halal labeling, brand image and quality product whether it had a simultaneous and partial effect on consumer purchasing decisions on cosmetic products The type of research used is causal research using direct interviews with questionnaire tools to respondents. The location of this research is at Mojopahit Street 666 B Sidoarjo Campus 1 Muhammadiyah University Sidoarjo While the sample used as many as 100 respondent. Sampling technique used is nonprobability sampling with accidental sampling technique. Data was collected through questionnaire distribution and multiple linear regression data analysis with SPSS statistic 22. From the results of research indicate that halal labeling (X1), brand image (X2) and product quality (X3) will have a good impact on the purchase decision (Y) of Muhammadiyah Sidoarjo University Students of 7,065%.
Innovation Organization and Free Float on Financial Performance: Empirical Study from Listed Company at Indonesia Stock Exchange
Authors: . Mulyono , Manurung Adler Haymans , Suprapto Adi Teguh
Published: October 2019

The aim of this research is to determine the effect of innovation organization and free ﬂoat on ﬁnancial performance with ﬁrm size as a moderating variable. Data collection techniques are used to conduct interviews and distribute questionnaires to the management of ﬁnancial companies listed on the Indonesia Stock Exchange. The analytical method used in this study is structural equation modeling using software data processing Smart PLS. The research results of the Innovation Organization have a negative and signiﬁcant effect on Financial Performance, Free Float has a positive and signiﬁcant effect on Financial Performance, and Free Float has a positive and signiﬁcant effect on Financial Performance by being moderated by Firm Size.
The Effects of Service Quality on Customer Satisfaction and Loyalty in a Logistics Company
Authors: Sutrisno Angeline , Andajani Erna , Widjaja Fitri Novika
Published: October 2019

Service quality plays crucial role in the operational activities of a company since service quality heavily affects the satisfaction and the loyalty of a customer. The aim of this study is to analyze the effects of service quality of a logistics company on customer’s satisfaction and loyalty. The service quality was measured using the following ﬁve dimensions of information quality, ordering procedures, timeliness, order condition and order discrepancy handling. Courier services or logistics services have been standardized in such a way to generate satisfaction to the customers and thus, achieving customer loyalty. The data processing in the logistics company was performedusingAMOS-StructuralEquationModeling(SEM).Thesamplingtechniquein thestudywasbasedonconveniencesamplingof150respondentsfromcourierservice companies (non-probability sampling). The data were collected using questionnaires distributed to the suitable population. The result of the study conﬁrmed the effects of the service quality of courier service companies on customer satisfaction and loyalty. In addition, the study conﬁrmed the relationship between customer satisfaction and loyalty.
Work Family Conﬂict among Female Employees: A Study on Private Hospital Nurses in Jambi
Authors: . Anisah , . Ubaidillah , . Sakinah
Published: October 2019

The aims of this study was to see how work-family conﬂict can have an impact on job stress and the performance of female employees, the sample in the study was nurses of private hospitals in Jambi who had a dual role as nurses as well as housewives. This research is a type of survey research, data collection techniques using a closed questionnaire given to respondents, the questions in the questionnaire were made using a Likert scale and analyzed using Component-Based SEM (Structural Equation Modeling),namely plus(PartialLeastSquare).theresultsofthestudyshowedthatwork family conﬂict had a positive effect on job stress, and negatively affected on nurse performance.
The Role of Work Stress as a Mediating Variable in The Relationship Between Workload and Intention to Leave
Authors: Ariﬁani Dini , Amalia Aura , Naibaho Hastuti , Pitaloka Endang
Published: October 2019

Jobs with high workload characteristics will require employees to work more than normal working hours so that employees will often work overtime. This condition will cause employees to be exhausted both physically and mentally which ultimately creates work stress. Job stress will cause employees to experience health problems. Employees who experience job stress will consider leaving the organization and looking for new jobs that can reduce their work stress. Respondents of this study were employees of telecommunications companies in the digital ﬁnancial services department. The questionnaire was distributed to all employees in the digital ﬁnancial service department of a leading telecommunications company in Indonesia. The questionnaire was distributed to 100 employees. However, only 60 questionnaires can be used for hypothesis testing (the response rate of this study is 60%). Hypothesis testing using hierarchical linear regression. The three hypotheses proposed in this study are supported, namely (1) workload has a positive and signiﬁcant effect on work stress (H1; p<.001); (2) work stress affects the intention to leave (H2; p<.001; and (3) work stress as a mediating variable in the relationship between workload and intention to leave the company (H-3; p<.001).
Higher Education Strategy: Sustainable Competitive Advantages in Niche Market Segment
Authors: Widiati Endah , Sefudin Akhmad
Published: October 2019

High numbers of HEI in Indonesia, make competition between HEIs is high. Primarily middle up segments. Those HEIs also compete with overseas HEIs which establish in domestic. While in middle low segment (niche market) the competition seems in medium situation. This research aims at ﬁnding the HEIs sustainable competitive advantage in serving niche market. The methodology used in this study was a qualitative descriptive analysis. Using 3 HEIs as research objects. The ﬁndings show that Financialmanagementcapability,ﬁxedasset,geographical location, human resources, networking and partnership, technology, organization capability and consumer loyalty becomes sustainable competitive advantages of HEIs in serving and competing in niche market.
The Role of Social Capital in the Fintech Application with the Crowdfunding Scheme
Authors: Hesti K Diyah
Published: October 2019

The crowdfunding phenomenon began to develop in Indonesia since the emergence of various applications that used crowdfunding schemes such as akseleran.com, kitabisa.com, wecare.id, gandengtangan.com, wujudkan.com. Crowdfunding has the hallmark of mutual funds that are interconnected usually through the internet, to invest and support efforts initiated by other people and organizations. Community involvementincrowdfundingrequiressocialcapitalintheformoftrust,socialnetworks and norms. Various studies of crowdfunding and social capital ﬁnd the role of social capital in the development of crowdfunding. This article intends to gather various views on the role of social capital in ﬁntech applications with crowdfunding schemes in Indonesia and abroad. The development of crowdfunding is not only inﬂuenced by social capital but also by regulations governing crowdfunding schemes in each region. Therefore it is important to develop regulatory policies that support the development of crowdfunding and also increase the involvement of the community.
The Roles of Trust within Information Quality and Price to Engage Impulsive Buying Behaviour to Generate Customer’s Repurchase Intention: A Case of M-Commerce in Indonesia (GoFood)
Authors: Prastiwi Septi Kurnia , Iswari Putu Widhi
Published: October 2019

The purpose of this study is to examine the customer’s impulsive buying behavior engage with trust, which involves price and information quality to determine the repurchase intention of the customers. The research model was analyzed using Regression Analysis by SPSS of 100 respondents who had previously completed the questionnaire. The proposed model and hypotheses are supported this study. Our ﬁndings that Price and Information Quality signiﬁcantly inﬂuenced to Impulsive Buying in strong and signiﬁcant effects, Information Quality signiﬁcantly inﬂuenced to Repurchase Intention, although the Price variable had a weak correlation with Repurchase Intention, we believe that Trust as a mediator variable of Impulsive Buying have a signiﬁcant impact on customer’s Repurchase Intention.
The Effect of Maqashid Sharia, Competitive Advantage, Entrepreneurial Networking and Sharia Compliance on KS212 Performance
Authors: Suryaputri Rossje V , Farikhin Ahmad
Published: October 2019

This study aims to analyze Sharia Maqashid, Competitive Advantage, Entrepreneurial Networking,andshariacomplianceontheperformanceofKS212(KoperasiSyariah212). Case study on the 212mart. The hypothesis test is using multiple linear regression analysis with Maqashid Sharia, Competitive Advantage, Entrepreneurial Networking, and sharia compliance as independent variables, and cooperative performance as the dependent variable. The data used in this study are primary data with purposive sampling techniques collected through interviews and questionnaires in May 2018. The 112 respondents in this study consist, KS212 manager, 212 community administrators and managers of 212mart in Bekasi City, Bekasi Regency, and Bogor Regency. The results showed that all independent variables simultaneously had a positive and signiﬁcant effect on the dependent variable, although partially maqashid sharia, entrepreneurial networking, and sharia compliance did not signiﬁcantly inﬂuence cooperative performance.
A Narrative Analysis Using the Concept of Tabligh on the Obligation of Financial Statements Disclosure
Authors: Aziza Nur , A. Birton M. Nur
Published: October 2019

Facts show that the rate of the disclosure ﬁnancial statements by full-ﬂedged sharia ﬁnancecompaniesinIndonesiaisstillhighlylimited.Outofthreecompanies,onlyPT.Al Ijarah Indonesia Finance which give full and voluntary ﬁnancial statements disclosure. This research aims to reveal the motivation of ﬁnancial statements disclosure by full-ﬂedged sharia ﬁnance companies using the concept of tabligh. This research uses theparadigmof tauhidandqualitativeapproach.Dataiscollectedbyintervieweingfour key informants from PT Al Ijarah Indonesia Finance to uncover motives and document study. Data is analyzed using Greimas’ structural narrative analysis and combined with the concept of tabligh. The results of the research show that the motive of ﬁnancial statements disclosure by PT Al Ijarah Indonesia Finance is to communicate (tabligh) the ﬁnancial statements to the stakeholders so that a broad and clear picture of the company is provided. Communicating (tabligh) informations broadly and clearly is what PT Al Ijarah Indonesia Finance aims for, which can be explained in several narrative relations; ﬁrst, internal relations in which the constraints of ALIF internal disclosure become the consideration for the publication goodwill, which when combined with the concept of tabligh becomes the foundation of the disclosure. Second, the extent and content of the disclosure in the relation of subject and object as an informative disclosure, and when combined with the concept of tabligh becomes an extensive disclosure. The last relation is the disclosure media as the target of disclosure in the relation of sender and receiver, so that when combined with the concept of tabligh it becomes an effective act of communication.
Determinants of Earnings Management and Its Implications on the Integrity of the Financial Statements
Authors: Priharta Andry , Rahayu Dewi Puji
Published: October 2019

This study aims to estimate and analyze the effect of corporate governance, audit quality, ﬁrm size, and leverage towards earnings management and its implications on the integrity of the ﬁnancial statements, either partially or simultaneously. The research method used is panel data regression analysis. By using purposive sampling method, there are six companies that consistently follow corporate governance perception index (CGPI) program from 2010 to 2015 and listed on the Indonesia Stock Exchange.The results show that, in the ﬁrst model, CGPI partially has a signiﬁcant negativeeffect,auditqualitypartiallyhasasigniﬁcantnegativeeffect,ﬁrmsizepartially has a signiﬁcant negative effect, leverage partially has a signiﬁcant positive effect, on earnings management. CGPI, audit quality, ﬁrm size, and leverage simultaneously have signiﬁcant effect on earnings management. In the second model, CGPI partially has a signiﬁcant negative effect, audit quality has a signiﬁcant negative effect, ﬁrm size has a signiﬁcant negative effect, leverage has a signiﬁcant positive effect, on earnings management. CGPI, audit quality, ﬁrm size, leverage, and earnings management simultaneously have signiﬁcant effect on the integrity of the ﬁnancial statements. According to these results, the company should maintain and improve corporate governance practices, uses the auditor services that have six quality factors (competence, independence, specialization, audit tenure, peer review, and afﬁliation), conveypositiveinformationrelatedtothecompanyandapplylowdebtratiowithgood planning. The investor should choose to invest in the companies that implement good corporate governance, using qualiﬁed audit services, investment priorities in large companies, and companies with low leverage.
BOND MARKET EFFICIENCY AND VOLATILITY: EVIDENCE FROM RUSSIA
Authors: Omran Shadi , Semnkova Elena
Published: October 2019

Purpose of the study: In this paper, we use daily return for the Moscow Exchange Government Bond index (RGBITR) and Moscow Exchange Corporate Bond index (MICEXCBITR) over the period 2013 to 2018.

Methodology: Normality test, unit root test (ADF) and Generalized Autoregressive Conditional Heteroscedasticity (GARCH) model will be used in this paper.

Results: The empirical results reveal that both government and corporate bond markets in Russia are not weak-form efficient. Furthermore, the volatility is persistent in both bond indices and resembles the same movement in returns. We find also that the GARCH (1,1) model is a good representation of the behavior of daily bond index returns in corporate and government bond markets in Russia.

Applications of this study: This research can be used for the universities, teachers, and students.

Novelty/Originality of this study: In this paper, for the first-time model of bond market efficiency and volatility has been studied.
GRAMMATICAL COMPARISON OF NOUN; INDONESIAN AND JAPANESE LANGUAGES
Authors: Kartika Diana , Erlanda Edel Eky , Atmazaki
Published: October 2019

Purpose of the study: The purpose of the study was to analyze the grammatical function of the noun of Japanese and Indonesian language and diversification of Noun and the system of inflectional of two language

Methodology: The methodology of the study was qualitative that focused on library research. In this case, the author conducted constructive analysis to analyze the similarities and differences of the languages in terms of form and function by text-book based on Indonesia and the Japanese Language. The text-book based constructive analysis of library research was chosen to be able to evaluate and renovate the text-book used by language students; Indonesian and Japanese so that their understanding of language comparison and contrast of those languages would be better in the future. Additionally, the lingual contrastive theory was also applicated to establish the term of comparison of the noun of Indonesian and Japanese. From the analysis of the data, it found that the diversity of Noun Forms of Japanese as the subject or the object is classified by particles such as WA,O. A different variation is reflected in the form of the noun of Indonesian where it is not followed with the word of the object.

Main Findings: This study also found that the equality form of Noun between Indonesian and Japanese in terms of the function of the subject and the object that refers to the name of people, place, etc.

Applications of this study: The implication of the study is applicated with the process of language acquisition of Japanese as the foreign language of Indonesian students, especially in evaluating and renovating the text-book used by students.
The Study of the Distribution and Deformation of Burden Layer in 250 Ton/Day Mini Blast Furnace Using Discrete Element Method
Authors: Pintowantoro Sungging , Hidayat Mas Irfan P. , Abdul Fakhreza , Febrianto Mohammad Rizki , Syaifullah Hamzah
Published: October 2019

Based on the abundant nickel ore resources in Indonesia, it is necessary to develop nickel ore processing technology. One of the commercially proven nickel processing technology is Mini Blast Furnace (MBF). The feeding process in MBF using charging system. So, the burden material distribution in MBF can be controlled. The burden material controlling is important process in MBF. The distribution of burden material will affect the gas flow in MBF. This research focuses to study the effect of large bell diameter size to burden materials distribution in MBF using Discrete Element Method. After analysis, the differences of large bell diameter size will affect the burden materials distribution. If the diameter of large bell is greater, the impact point during charging process will be closer to the wall area. Then, the impact area on the surface of the layer will be on top of the layer. The distribution of burden materials in MBF is influenced by large bell size, kinetic energy at impact, particle mass, and particle size and layer stability. For particles distribution, the particles with small density (coal and dolomite) tend to be concentrated in the center zone. On the other hand, the particles with large density (ore) tend to be concentrated in the intermediate and peripheral zone. For the MBF start-up process, the best gas flow can be achieved by using large bell and MBF inner diameter ratio of 7: 10.
Preliminary Characterization of Crude Lectins Fractions of Red Macroalgae Species Collected from the Southern Coast of Gunungkidul Indonesia
Authors: Anam Choirul , Praseptiangga Danar , Fajarningsih Nurrahmi Dewi , Chasanah Ekowati , Yunus Ahmad
Published: October 2019

Lectins or hemagglutininsare specific sugar-binding proteins (glycoproteins) of non-immune origins that typically agglutinate certain cells and/or precipitate glycoconjugates. This study aimed to evaluate the activity of hemagglutination, protein comtent, and initial characterization (the stability towards pH, temperature, divalent cation and inhibition of hemagglutination activity by sugars and/or glycoproteins) crude lectins fractions of red macroalgae from the coast of Gunungkidul Beach, Yogyakarta. The findings showed that hemagglutination activity using trypsin treated rabbit erythrocytes of crude fractions of red algae lectins Nitophylium punctatum species, Helminthora divaricata, and Acanthophora spicifera were 26, 26, and 213, respectively. The protein contents were 8,123.47 Î¼g / ml; 9,545.65 Î¼g / ml; and 7,368.45 Î¼g / ml. Although the three red macroalgae species tend to maintain a relatively stable pH, their temperature tolerance was unstable, and were unaffected by divalent cations. The carbohydrate-binding specificities assay of the red macroalgae species showed the occcurence of inhibition in certain glycoproteins and not simple sugars.