bluuebunny/crossref_metadata_2025 huggingface dataset:
PENERAPAN FLIPPED CLASS LEARNING DALAM PEMBELAJARAN IPS SMPN 16 MALANG
Authors: Azizah Siti Ismi Nur , Irawan Listyo Yudha
Published: January 2025

Abstract: The purpose of applying this flipped class learning model is to facilitate students and provide innovation to teachers in the learning process. The strategy of implementing this activity uses the methods used, including lectures, discussions, literature studies. The results obtained in this activity make grade IX-G students of Junior High School 16 Malang in social studies learning have sufficient provisions in creating effective classes using a Flipped Class Learning (FCL) learning model. The benefits arising from all activities carried out in this article are described through direct and indirect benefits..
MENINGKATKAN MOTIVASI BELAJAR KELOMPOK DENGAN MEDIA WORD WALL MATA PELAJARAN INFORMATIKA KELAS X
Authors: Hidayat Manik , Patmanthara Syaad
Published: January 2025

Abstract: This study aims to explore the effectiveness of the Word Wall media in enhancinggroup learning motivation in the subject of Computer Science at the high schoollevel, specifically for tenth-grade students. The Word Wall method is implementedas a collaborative approach that combines interaction between tea chers andstudents with the use of key word visualizations. The study involved X tenth-gradestudents as the sample. The research method employed was classroom actionresearch, utilizing observation, questionnaires, and interviews as data collectioninstruments. The results of the study indicate a significant increase in group learningmotivation following the implementation of the Word Wall media. Studentsdemonstrated more active participation in the learning process, enhancing theirunderstanding of the material, and developing collaborative skills. These findingssuggest that the Word Wall media has the potential to significantly enhance studentlearning motivation in the context of group learning in the Computer Sciencesubject. Practical implications and recommendations for further research arediscussed in the abstract
PENGEMBANGAN MEDIA PEMBELAJARAN FLASHCARD GUNA MENUNJANG PROSES PEMBELAJARAN MODEL MAKE A MATCH UNTUK MENDUKUNG KEMAMPUAN PEMECAHAN MASALAH PESERTA DIDIK
Authors: Widahyanti Widahyanti , Utami Anita Dewi
Published: January 2025

Abstract: Learning media has not been fully used in the learning process. In fact, learningmedia is an important component that can be used to help the learning processbecome more enjoyable, effective and efficient so that meaningful learning occurs.The development of learning media is very necessary to be able to support alearning process and support students' abilities. The aim of the research is todevelop flashcard learning media to support the make a match model learningprocess to support students' problem solving abilities. The method in this researchis research and development (Research & Development) referring to the ADDIEmodel which consists of analysis, design and development. The research subjectwas flashcard learning media in the make a match learning model in mathematicsmaterial and the test subjects were teachers and students at SMP Negeri 9 Malang.Based on the results of the data analysis obtained, it was concluded that theflashcard learning media that had been developed had a very valid category interms of the percentage of media suitability of 92.5%, validation of the material wasincluded in the very valid category with a percentage of 95%. Interviews conductedwith students also showed that students became more active, helpful andenthusiastic and supported students' problem solving abilities when flashcardmedia was used in the make a match type cooperative learning model
PENGEMBANGAN MEDIA PEMBELAJARAN GAME EDUKASI ROLE PLAYING GAME (RPG) UNTUK MENINGKATKAN MOTIVASI BELAJAR SISWA PADA MATERI PENCEMARAN LINGKUNGAN
Authors: Sandi Ferryan
Published: January 2025

Abstract: Natural science is a science that studies natural phenomena using a scientificapproach and is taught in an integrated manner at the level of junior high schooleducation. One of the topics in the junior high school science subject isenvironmental pollution. The environmental pollution topics can be accepted easilyif students can observe, feel, or experience them directly. At the location of thisresearch, the condition of the school environment is a clean and orderlyenvironment. This results in the lack of the phenomenon of environmentalpollution that can be used as a source of learning. In addition, the use of minimallearning media makes students less actively involved in learning so that studentsare less motivated in participating in learning. Therefore, this research wasconducted by developing learning media products in the form of RPG educationalgames on environmental pollution materials to increase students' learningmotivation. This type of research is research and development (R&D) with theADDIE development model. This research produces learning media products in theform of RPG educational games that are suitable for use with a media validationscore of 85.53 percent, material validation of 77.08percent, readability scores of 85.50percent and thelevel of student motivation to learn using RPG educational game learning media of82.11percent. Based on these results, it can be concluded that the learning media arevalid and feasible to use.
INOVASI PEMBELAJARAN ABAD 21 MEDIA APLIKASI BERBASIS WEBSITE “WORDWALL” DAN PENERAPANNYA DI SEKOLAH DASAR
Authors: Alwi Marzuki , Kurniawan Citra
Published: January 2025

Salah satu pendekatan untuk memenuhi kebutuhan peserta didik dalam pembelajaran yang efektif adalah mengenal peserta didik dengan lebih dekat. Pada abad 21 saat ini, peserta didik cenderung lebih dekat dengan dunia digital, seperti media sosial dan media game aplikasi. Oleh karena itu guru dituntut untuk menguasai dan memanfaatkan aplikasi game edukasi sebagai alat untuk mendekati peserta didik. Jenis penelitian ini adalah kualitatif deskriptif studi kasus (case study). Penelitian ini dilaksanakan waktu kegiatan PPL mahasiswa di SDN Model Kota Malang dengan sasaran penelitian adalah peserta didik kelas 4A. Pengambilan data dilakukan peneliti dengan observasi dan dokumentasi yang dibantu oleh rekan PPL ketika pelaksanaan praktek pembelajaran terbimbing.Pelaksanaan inovasi pembelajaran abad 21 media aplikasi berbasis website “wordwall” pada pelaksanaan PPL di SDN Model Kota Malang yang dilakukan mahasiswa ketika melaksanakan praktek pembelajaran terbimbing di kelas 4A mendapat sambutan yang menyenangkan dari peserta didik, mereka sangat menyukai pembelajaran yang interaktif. Pelaksanaan inovasi pembelajaran abad 21 media aplikasi berbasis website “wordwall” dan penerapannya di sekolah pada pembelajaran pancasila yang dilaksanakan mahasiswa PPL merupakan salah satu bentuk solusi dalam mengikuti arus teknolgi yang sudah berkembang, di sisi lain penerapan ini dalam rangka memenuhi kebutuhan peserta didik yang memiliki karakteristik sangat suka dunia digital.
IMPLEMENTASI ETNOMATEMATIKA MELALUI MAKANAN TRADISIONAL BERBASIS PENDEKATAN CULTURALLY RESPONSIVE TEACHING MATERI BALOK DAN KUBUS KELAS IV SDN CIPTOMULYO 1 MALANG
Authors: Sausanti Salwa , Anggraini Ade Eka , Saadah Hikmatus
Published: January 2025

Tujuan dari penelitian ini adalah untuk mendeskripsikan implementasi etnomatematika melalui makanan tradisional pembelajaran matematika siswa kelas IV sekolah dasar. Penelitian ini menggunakan pendekatan kualitatif jenis kualitatif deskriptif. Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi yang dilakukan pada saat kegiatan pembelajaran matematika di SDN Ciptomulyo 1 Malang. Berdasarkan hasil penelitian diperoleh hasil bahwa pembelajaran matematika di kelas IV SDN Ciptomulyo 1 Malang belum menghubungkan antara matematika dengan budaya sehari-hari peserta didik. Berdasarkan hasil penelitian diperoleh hasil bahwa menghubungkan pembelajaran matematika dengan budaya mampu menghasilkan pembelajaran yang menyenangkan dan bermakna. Implementasi etnomatematika melalui makanan tradisional mencakup beberapa hal yaitu: 1) meningkatkan semangat belajar peserta didik dan meningkatkan berpikir kritis peserta didik mengenai materi bangun ruang balok dan kubus, 2) memberikan pemahaman konsep matematika diantaranya dapat mengkonstruk pemahaman peserta didik melalui eksplorasi makanan tradisional dalam kehidupan sehari-hari, 3) memberikan pemahaman bermakna bagi peserta didik mengenai materi balok dan kubus, dan 4) memberikan pemahaman konsep matematika mengenai materi balok dan kubus yang abstrak menjadi konkret.
KONTRIBUSI KEPERCAYAAN DIRI DAN PENERIMAAN DIRI TERHADAP CITRA TUBUH SISWA KELAS X SMA NEGERI 1 MALANG
Authors: Putri Amelia Wahyuning , Flurentin Elia
Published: January 2025

Siswa yang menganggap fisiknya tidak menarik sehingga rela mengubah fisiknya supaya dapat diterima teman sebaya menandakan siswa mempunyai citra tubuh negatif. Hasil penelitian terdahulu lebih dari 50% remaja mempunyai citra tubuh negatif. Berdasar penelitian terdahulu citra tubuh dipengaruhi kepercayaan diri dan penerimaan diri. Penelitian ini bertujuan untuk membuktikan kontribusi kepercayaan diri dan penerimaan diri terhadap citra tubuh. Penelitian ini menggunakan desain korelasional. Sampel penelitian yaitu 104 siswa dari 297 siswa kelas X SMAN 1 Malang, didapat dengan teknik cluster sampling. Pengumpulan data penelitian menggunakan skala kepercayaan diri, skala penerimaan diri, dan skala citra tubuh. Data penelitian dianalisis dengan regresi linear sederhana dan regresi linear berganda dan bantuan program SPSS 25 for Windows. Hasil regresi linear sederhana kepercayaan diri terhadap citra tubuh menunjukkan nilai Sig. 0,017 ≤ 0,05, hal ini berarti kepercayaan diri berkontribusi positif signifikan terhadap citra tubuh. Hasil regresi linear sederhana penerimaan diri terhadap citra tubuh menunjukkan nilai Sig. 0,000 ≤ 0,05, hal ini berarti penerimaan diri berkontribusi positif signifikan terhadap citra tubuh. Hasil regresi linear berganda kepercayaan diri dan penerimaan diri terhadap citra tubuh menunjukkan nilai Sig. 0,001 ≤ 0,05, hal ini berarti kepercayaan diri dan penerimaan diri secara simultan berkontribusi positif signifikan terhadap citra tubuh.
MENINGKATKAN EKSISTENSI PESERTA DIDIK MELALUI BIBLIO-KONSELING BERBASIS NOVEL FIKSI “SANG ALKEMIS”: STUDI LITERATUR
Authors: Mahdiyah Mahirotul
Published: January 2025

Pada hakikatnya, manusia selalu berusaha menciptakan segala makna dari peristiwa yang terjadi di hidupnya. Namun tidak jarang individu tersebut juga mengalami krisis eksistensialisme yang berupa kecemasan, kehilangan makna dan tujuan hidup, atau lain sebagainya. Pelaksanaan konseling eksistensialisme diharapkan dapat meningkatkan eksistensi seseorang dengan memiliki kesadaran penuh atas hidup dan pilihannya. Salah satu teknik konseling yang dapat digunakan untuk permasalahan tersebut adalah teknik bibliokonseling dengan menggunakan media novel yang berjudul sang alkemis. Alasan pemilihan novel tersebut adalah karena isi dari novel tersebut menceritakan seorang anak yang melakukan pengembaraan untuk mencari harta karun dan tidak berhenti untuk mewujudkan mimpinya. Konflik eksistensial yang dialami dan makna-makna yang terkandung dalam buku tersebut diharapkan dapat menjadi referensi konselor untuk memberikan layanan konseling dengan permasalahan eksistensial. Penulisan artikel ini menggunakan metode studi literatur dengan melakukan pengkajian terhadap novel sang alkemis tersebut dan melakukan analisis terkait dengan teori-teori eksistensialisme. Pada rancangan konseling, terdapat dua sesi yang dapat diterapkan oleh konselor dan juga dapat dilakukan modifikasi jika diperlukan.
DAMPAK PENERAPAN SISTEM BLOK TERHADAP KETERLAKSANAAN MATA KULIAH PPL 1 PPG PRAJABATAN INFORMATIKA DI SMKN 10 MALANG
Authors: Islamia Lailatul , Lestari Dyah , Sutrisno Sutrisno
Published: January 2025

Pendidikan Profesi Guru (PPG) Prajabatan Universitas Negeri Malang didalamnya terdiri dari berbagai mata kuliah wajib salah satunya yaitu mata kuliah PPL 1 yang harus dilaksanakan oleh mahasiswa PPG Prajabatan. Praktik Pengalaman Lapangan (PPL) merupakan suatu kegiatan yang wajib ditempuh oleh mahasiswa PPG dari berbagai program studi. Program ini memberikan kesempatan kepada mahasiswa untuk mendalami dan memantapkan kompetensinya sebagai guru bidang studi. Penelitian ini bertujuan untuk mengetahui dampak penerapan sistem blok terhadap keterlaksanaan mata kuliah PPL 1 PPG Prajabatan informatika di SMKN 10 Malang. Metode yang digunakan yaitu metode observasi dan metode wawancara. Subjek penelitian yaitu guru mata pelajaran informatika selaku guru pamong dan mahasiswa PPG Prajabatan gelombang 1 tahun 2024 yang mana subjek ini yang merasakan dampak dari sistem blok di SMKN 10 Malang. Hasil penelitian menunjukkan bahwa penerapan sistem blok terhadap keterlaksanaan mata kuliah PPL 1 PPG Prajabatan tahun 2024 bidang studi informatika di SMKN 10 Malang cenderung berdampak negatif. Hal ini dikarenakan dengan adanya penerapan sistem blok menghambat keterlaksanaan PPL di SMKN 10 Malang khususnya pada bidang informatika, baik dari sisi mahasiswa maupun dari sisi guru pamong. Permasalahan ini terjadi dikarenakan penjadwalan sistem blok yang sudah dibuat di sekolah tidak sesuaidengan jadwal PPL mahasiswa yang sudah ditetapkan.
PROFIL KESADARAN BUDAYA KONSELOR DI KOTA SURABAYA MENURUT PRESPEKTIF SISWA
Authors: Saputra Alfian Dwi , Muwakhidah Muwakhidah , Prianata Cahyadi , Pae Eka Wahyu Ningsih , Febrianti Firda Sania Nur , Putri Nadira Aulia Rizqiana , Purnama Nurria Ayu Devi
Published: January 2025

Abstract: Culture is customary thinking, something that has developed has become a habit that is difficult to change. The purpose of this research is to find out the level of cultural awareness of counselors’. The research subjects were 62 students obtained using random sampling techniques. This type of research uses quantitative design with a descriptive survey approach. The research instrument used a cultural awareness questionnaire based on Sue&Sue's theory. The data analysis technique used descriptive statistical analysis. Based on the results of data analysis, the results showed that the level of cultural awareness of counselors was in the low category at 65percent and in the medium category at 35percent. So counselors' cultural awareness from the students' perspective is still low. So there needs to be support from the school in providing training to make guidance and counseling teachers more professional.
PEMBELAJARAN PENDIDIKAN JASMANI MODEL COOPERATIVE LEARNING TIPE JIGSAW TERHADAP PENINGKATAN HASIL BELAJAR RANAH KOGNITIF, AFEKTIF & PSIKOMOTOR
Authors: Purnomo Triatmo Joko , Adi Sapto , Darmawan Arief , Yudasmara Dona Sandy
Published: January 2025

Abstract: The purpose of writing a literature review is to determine and examine the effectiveness and influence of physical education learning through a cooperative model using one type of jigsaw or zig-zag forming small groups consisting of materials and experts. This method uses PRISMA to filter data acquisition after being obtained. The results of accessing articles from Google Scholar obtained 10 articles published in journals, 5 international and 5 national. The conclusion is that the use of the jigsaw type cooperative model in physical education learning improves learning outcomes from all cognitive, affective, and psychomotor aspects, this is due to the influence of learning experiences, a sense of responsibility, and cooperation between colleagues.
PENANGANAN KASUS PELECEHAN SEKSUAL TERHADAP SISWA SMP MELALUI PENDEKATAN BIMBINGAN DAN KONSELING: TANTANGAN DAN STRATEGI
Authors: Siara Maya Enggar
Published: January 2025

Sexual harassment against junior high school students is a serious issue that can impact their mental, emotional, and academic well-being. This research aims to explore the challenges in addressing sexual harassment in junior high schools and the counseling strategies that can be used to address this issue. Several solutions have been implemented, such as training for teachers and counselors, strengthening school policies, and empowering students to report harassment cases. However, the success of implementing these solutions is hindered by a lack of resources and interagency coordination. This study uses a qualitative approach with a focus on case studies to deeply understand cases of sexual harassment in junior high schools. Data were collected through observations, documentation, and interviews with students, teachers, counselors, and parents. The results indicate various forms of harassment, student responses, the role of guidance counselors, risk factors, and psychological impacts. From the findings of this research, it can be concluded that counseling approaches have a positive impact on helping sexual harassment victims by providing a safe space, emotional support, coping strategies, and assistance in reporting to authorities. Recommendations include strengthening the role of guidance counselors, comprehensive sexual education, enhancing supervision and school culture, and fostering collaboration with parents. It is hoped that this research will make a significant contribution to protecting the well-being of junior high school students and strengthening the role of counseling in schools.
Development of Guided Writing Teaching Materials Based on High Order Thinking Skills for Grade VI Elementary School Students
Authors: Wicaksono Meidias Abror , Zulaeha Ida , Purwati Panca Dewi
Published: January 2025

This study aims to develop guided writing teaching materials based on High Order Thinking Skills (HOTS) with the 4-D development research model approach (Define, Design, Develop, Disseminate). The development process begins with the define stage to identify student needs and analyze the curriculum, followed by the design stage to design the initial teaching materials. At the develop stage, the teaching materials were validated by media experts and material experts, and tested on 28 students of grade VI state elementary school 01 Wates Semarang. The last stage, disseminate, was conducted to disseminate the product openly to teachers and students in the context of learning. The results showed that validation from media experts resulted in an average score of 90.5% (very feasible category), while validation from material experts resulted in an average score of 92% (very feasible category). The trial of the developed teaching materials to 28 elementary school students of grade VI state elementary school 01 Wates in Semarang City and the results of the comparison between pretest and posttest were -4.543, with a p value (Asymp. Sig.) of 0.000 (p < 0.05) with an effective category of improving students' writing skills by providing stimulation to think critically, analytically, and creatively according to HOTS characteristics. Thus, the development of HOTS-based writing teaching materials can be an effective innovation in literacy learning in elementary schools, especially to improve in-depth and meaningful guided writing skills. This study recommends wider implementation of this teaching material in other classes as well as further development based on digital technology to reach a wider audience.
Analisis Penerapan dan Manfaat Blended Learning dalam Pembelajaran Pendidikan Jasmani
Authors: Purnomo Triatmo Joko , Ittaqwa Ittaqwa , Lupita Nasmay
Published: January 2025

Pendidikan jasmani merupakan bagian dari pendidikan yang dilakukan melalui aktivitas jasmani dengan tujuan mengembangkan aspek kognitif, afektif, dan psikomotor. Aspek kognitif yaitu kemampuan berfikir dalam pengetahuan tentang gerak. Aspek afektif yaitu sikap, rasa peduli, dan menghargai pentingya melakukan aktivitas jasmani. Aspek psikomotorik yaitu ketrampilan gerak yang dimiliki siswa, beruhubungan dengan fisiologis untuk pertumbuhan dan perkembangan. Pelaksanaan pembelajaran yang efektif tentunya memadukan teknologi yang ada. Blended learning yaitu metode belajar campuran dengan menggabungkan pembelajaran tatap muka, offline dan online. Penerapan pembelajaran gabungan akan bermanfaat dalam proses pembelajaran sehingga menambah wawasan dalam pengetahuan dan memecahkan permasalahan pembelajaran. Demikian penerapan pembelajaran pendidikan jasmani dilakukan dengan blended learning akan memberikan manfaat bagi siswa, guru dan lembaga pendidikan sehingga tercapai tujuan pendidikan itu sendiri.
Risk assessment and management strategies for peri-implantitis in high-risk populations⁠
Authors: Batwa Mohammed A. , Alenazi Nassren F. , Aldubayyan Raed A. , Alshehri Mohammed A. , Alanazi Abdulmajed A.
Published: January 2025

Peri-implantitis is a multifactorial condition characterized by inflammation and progressive bone loss surrounding dental implants, often leading to implant failure. High-risk populations, including patients with systemic conditions such as diabetes or undergoing cancer treatments, face an elevated susceptibility due to impaired immune responses and altered bone metabolism. Understanding the pathophysiological mechanisms underlying the disease is essential for effective risk assessment and management. Dysbiosis of the microbial biofilm, immune system dysregulation, and systemic factors like oxidative stress and cytokine imbalances are critical contributors to disease progression. These factors necessitate the development of targeted strategies for prevention and intervention. Risk assessment models have evolved to include advanced technologies such as artificial intelligence and decision tree regression to predict peri-implantitis in vulnerable individuals accurately. These tools incorporate systemic, local, and implant-specific parameters to enable personalized treatment planning and early intervention. Innovative management strategies have also emerged, ranging from adjunctive antimicrobial therapies, such as glycine powder air-polishing and localized drug delivery systems, to host modulation therapies and regenerative techniques. The use of advanced biomaterials, such as implants coated with bioactive peptides or antimicrobial nanoparticles, has further improved osseointegration and reduced infection rates. Regenerative approaches, including the application of growth factors like platelet-derived growth factor and bone morphogenetic proteins, have shown significant potential in repairing peri-implant defects and restoring functional stability. Emerging technologies, such as nanotechnology and bioengineered implants, offer new possibilities for real-time health monitoring and sustained therapeutic delivery at implant sites. These advancements, coupled with a deeper understanding of peri-implantitis etiology, provide a framework for optimizing outcomes in high-risk populations, addressing both the local and systemic challenges posed by the disease.
Utilization and benefits of point-of-care testing in primary healthcare⁠
Authors: Jumah Mohammed A. , Magliah Fisal F. , Ageel Salman A. , Almutairi Jouri A. , Alsubhi Wed A. , Alamer Shorouq A. , Alanazi Maryam A. , Alanazi Hejris J. , Alshaqha Rayan F. , Almoghrabi Dania M. , Alyusef Ali A. , Alkinani Hajer I.
Published: January 2025

Point-of-care testing (POCT) represents a transformative advancement in healthcare, enabling rapid and accurate diagnostics at or near the site of patient care. By reducing reliance on centralized laboratories, POCT expedites clinical decision-making and enhances healthcare delivery, particularly in underserved regions. Its application spans various medical fields, including infectious diseases, chronic disease management, and emergency care. Innovations such as molecular diagnostics, biosensors, and artificial intelligence (AI) integration have improved the precision, reliability, and accessibility of POCT devices, offering significant benefits for patient outcomes and healthcare efficiency. POCT has demonstrated its potential to reduce diagnostic delays, lower hospital admissions, and decrease the burden on overextended healthcare systems. Rapid diagnostics for conditions such as acute myocardial infarction, diabetes, and malaria have resulted in timely interventions, improving survival rates and reducing complications. In addition to clinical benefits, economic analyses highlight the cost-effectiveness of POCT, as it minimizes resource utilization and shortens patient treatment cycles. However, challenges persist in scaling POCT accessibility. Financial barriers, supply chain limitations, regulatory inconsistencies, and workforce training deficits impede its widespread adoption, particularly in low- and middle-income countries. Addressing these issues requires innovative funding models, global regulatory harmonization, and capacity-building initiatives to empower healthcare workers. Technological advancements continue to expand POCT's potential, integrating real-time diagnostics with digital health platforms and epidemiological surveillance systems. These developments promise not only to enhance healthcare delivery but also to improve public health responses to outbreaks and health crises. By bridging the gap between diagnostics and treatment, POCT offers a pathway to more equitable and efficient healthcare systems, transforming how and where care is delivered. Its integration into healthcare frameworks holds the potential to redefine patient care, fostering a future of accessible, high-quality healthcare for all.
Expert perspectives on the clinical use of meropenem monotherapy in the management of various antibiotic-resistant pathogens in Indian settings
Authors: S. Manjula , M. Krishna Kumar
Published: January 2025

Background: To gather expert perspectives on the clinical use of meropenem monotherapy in managing multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) pathogens in Indian settings.
Methods: This cross-sectional study used a 20-item questionnaire to gather clinician opinions on prescription practices, clinical observations, and preferences regarding meropenem monotherapy. Descriptive statistics were employed to analyze the responses, presenting frequencies as percentages.
Results: A total of 353 clinicians participated in this study, with 37% reporting a 6-10% prevalence of MDR, XDR, and PDR pathogens in their practice. Complicated intra-abdominal infections (cIAIs) were the most common conditions treated with meropenem, reported by 54.96% of respondents. The majority (91.5%) of the respondents preferred combination therapy for resistant infections, with tigecycline (54%) and colistin (33.43%) being common choices. Key pathogens included Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, Escherichia coli, and Staphylococcus aureus. Most participants (58%) favored administering 1g of IV meropenem in 2 to 3 divided doses. Bloodstream infections, meningitis, and ventilator-associated pneumonia (VAP) were noted as primary indications for meropenem use. Additionally, 68% of participants stated meropenem was the most prescribed antibiotic for complicated urinary tract infections (cUTIs), while 77% indicated it as the preferred treatment for Gram-negative MDR pathogens.
Conclusion: Meropenem remains a critical option for treating MDR, XDR, and PDR infections in India, particularly in combination with tigecycline or colistin. Clinicians preferred its use in cIAIs and VAP, especially in elderly patients. The findings highlight the importance of continuously monitoring resistance patterns to optimize treatment strategies.
Aprendizaje Autónomo de la Astronomía con Python y TIC
Authors: Basto Pineda Juan Carlos , Núñez de Villavicencio Luis Alberto , Guarín Rojas Juan Andrés , Guarín Velásquez Karol Fernanda
Published: January 2025

En este trabajo se presenta una estrategia novedosa para el aprendizaje autónomo de la astronomía a nivel universitario, apoyada en videotutoriales para redes sociales y una calculadora interactiva. El objetivo es acercarse al lenguaje de las generaciones nativas digitales y brindar elementos para un aprendizaje autogestionado de calidad.
Aprendiendo y Enseñando desde, con y para la UIS
Authors: Pinzón Jaile Liliana
Published: January 2025

El desarrollo de la clase correspondiente al área disciplinar y subárea de Formación Profesional, desarrollada en inglés, llamó la atención del estudiantado, quienes mencionaron que era la primera vez que relacionaban dicho idioma con un tema de su carrera: Trabajo Social. La puesta en marcha de una estrategia netamente participativa, donde sus compañeros socializaban un tema de TS con Grupos y Redes e invitaban al auditorio a leer, comprender y expresar sorprendió notablemente a los asistentes; algunos desde la incertidumbre, otros desde el temor y otros desde la complacencia. Respecto al material de trabajo en clase, este fue considerado como sencillo, dinámico y coherente de acuerdo con los pre saberes trabajados con anterioridad. Con respecto a la herramienta Word wall, esta fue catalogada como emocionante, divertida e interesante. En cuanto a la inclusión, algunos estudiantes sintieron temor de expresarse, pues reconocen que requieren de un mayor nivel de manejo del inglés; otros sintieron el reto de expresarse en otra lengua, y solo aquellos pocos que ya dominaban el idioma se sintieron seguros de expresarse. La participación fue del 100%, a pesar de que algunos intervinieron en español a causa de sus debilidades en la pronunciación. El refuerzo y la evaluación se logró con las actividades interactivas, realizadas por el 70%, quienes afirmaron que aprendieron una cantidad considerable de vocabulario. Finalmente, el 100% de los participantes quienes valoraron el proceso manifestaron que les gustó recibir la clase en inglés.
Detecting and explaining anomalies in industrial Internet of things systems using an autoencoder
Authors:   St. Petersburg Federal Research Center of the Russian Academy of Sciences, St. Petersburg, Russia, Levshun D.A. , Levshun D.S. ,   St. Petersburg Federal Research Center of the Russian Academy of Sciences, St. Petersburg, Russia, Kotenko I.V. ,   St. Petersburg Federal Research Center of the Russian Academy of Sciences, St. Petersburg, Russia
Published: January 2025

In industrial Internet of Things (IoT) systems, explaining anomalies plays a crucial role in identifying bottlenecks and optimizing processes. This paper proposes an approach to anomaly detection using an autoencoder and its explana-tion based on the SHAP method. The purpose of the anomaly explanation is to provide a set of data features in indus-trial IoT systems that most significantly influence anomaly detection. The novelty of this approach lies in its ability to quantify the contribution of individual features for specific data samples and to calculate an average contribution across the dataset, providing a feature importance ranking. The proposed approach is tested on Industrial IoT datasets with varying feature counts and data volumes. The anomaly detection achieves an F-measure of 88-93%, outperform-ing the comparable methods discussed. The study demonstrates how explainable artificial intelligence can identify the causes of anomalies in both individual samples and datasets as a whole. The theoretical importance of the proposed approach lies in its ability to shed light on the workings of intelligent detection models, enabling the identification of factors influencing their outcomes and uncovering previously unnoticed patterns. In practice, this method enhances security system operators' understanding of ongoing processes, aiding in threat identification and error detection within data.
IMPLICACIONES EN LA EDUCACIÓN HOY DE LA TRÍADA
Authors: Rodriguez Milagros Elena
Published: January 2025

Como objetivo de la indagación se sostiene la tríada transepistemes-decolonialidad-complejidad y sus implicaciones en la educación hoy. Lo realizamos con la hermenéutica comprensiva, ecosófica y diatópica, en los momentos analítico – empírico y los propositivos. En el momento propositivo evidenciamos que la tríada transepistemes-decolonialidad-complejidad irrumpe en la educación para romper con la educación reduccionista del ser humano; con la Inteligencias Artificiales y la debida vigilancia epistemológica a favor del hacer del discente; irrumpe en la educación para romper con las verdades impuestas de la ciencia moderna; la concordancia saberes-conocimientos, lo que lleva a decolonizar los conocimientos para complejizarlos; provocar el rompimiento de que sólo en el espacio físico de las instituciones educativas se aprende y va al aula mente-social-espíritu con la subjetividad-sentipensar-cotidianidad-cultura del discente; la concordancia saberes-conocimientos transdisciplinados, romper el pensamiento abismal entre las disciplinas, sin decolonialidad se pierde el vino nuevo en odre vieja como la parábola de nuestro Señor Jesucristo; se decoloniza la filosofía, educación y ciencias para educar en la complejidad del ser; la reforma del pensamiento y en ello los principios de la complejidad anidan relacionalidades en los conocimientos-saberes; las rupturas asignificantes con las imposiciones de superioridades en el conocer y minimización del ser humano y los deconstruyen para complejizarlos a la luz del sentipensar y la concordancia objetividad-subjetividad; el rompimiento de que sólo en el espacio físico de las instituciones educativas se aprende y va al aula mente-social-espíritu con la subjetividad-sentipensar-cotidianidad-cultura del discente.
Comparison of Anticancer Effects between Platinum Levetiracetam and Platinum Azidothymidine through the Expression of Biomarker Genes on Cancer Cell Lines
Authors: Sabokrouh Abdolreza , Ghaffari Nasim , Tafreshi Zahra Karimi , Atabi Freshteh , Sharifi Zohreh , Mostavafi Seyed Khalil Shokouhi
Published: January 2025

Background: The utilization of biomarkers is a way to assess the efficacy of recently created anticancer drugs. MiRNAs, telomerase, and Bcl-2 are extensively utilized as biomarkers for this purpose. This study aims to evaluate the comparison of the newly synthesized platinum compounds such as Platinum Azidothymidine (Pt-AZT) with Platinum Levetiracetam (Pt-Lev) on HepG2 cancer cell lines via the biomarkers.
Methods: In this study, cells were divided into four groups: Group A (HDF cells) were the normal negative control group, group B were HepG2 untreated cancer cells, and groups C and D were treated cancer cells with Pt-AZT and Pt-Lev, respectively. After evaluating the LC50 for the drugs by MTT test, the relative gene expression of the biomarkers was determined by qPCR.
Results: The results showed a significant decrease for antiapoptotic genes including miRNA-21 (5.1±0.014), telomerase (0.56±0.48), Bcl-2 (0.41±0.276) in group D, whereas in group C was more than group D for miRNA-21 (6.0±0.141), telomerase (3.49± 0.231), Bcl-2 (4.93±0.276) also there was a significant increase in miRNA-122 (33.97± 0.04) in group D, whereas in group C was (28.36±0.007) and so lower than group D. Most of the investigated groups showed a significant difference (p<0.05). In addition, there were widespread apoptotic regions in Pt-Lev treatment compared to Pt-AZT.
Conclusion: The advantages of using Pt-Lev were more powerful anticancer effects on biomarkers through inhibition of antiapoptotic and stimulation proapoptotic factors and also lower side effects and lower drug resistance than Pt-AZT; therefore, it can be considered a more effective anti-cancer therapy.
The Role of Disulfide Bridges in the Interaction of E. coli -Derived Recombinant SCARB2 and EV-A71's Capsid
Authors: Vo-Nguyen Hai-Vy , Tran Thuoc Linh , Tran-Van Hieu
Published: January 2025

Background: Hand, Foot, and Mouth disease is an acute infectious disease caused by a group of enteroviruses, including Coxsackievirus A16 and Enterovirus 71. EV-A71-causing disease can give rise to severe complications in children, leading to meningitis, encephalitis, and even death. A potential approach to prevent the virus spread is inhibiting the invasion of EV-A71 into target cells, thereby helping to prevent not only the spread of EV-A71 in the community but also lessen the risk of outbreaks. EV-A71 cell’s receptor, human scavenger receptor class B member 2, SCARB2, was used as a trap to gather the virus and limit its spreading.
Methods: In this study, the recombinant receptor was expressed using Escherichia coli (E. coli) system. SCARB2 proteins expressed from E. coli BL21(DE3), and E. coli SHuffle® T7 Express were in inclusion bodies and subsequently refolded into soluble forms with recovery efficiencies of 57.57, and 82.2%, respectively. The presence of intramolecular disulfide bridges in the refolded SCARB2 was examined by SDS-PAGE in combination with Dithiothreitol (DTT). The two proteins were then utilized to evalu-ate the interaction with EV-A71 capsid by Indirect Enzyme-Linked Immunosorbent Assay (ELISA) at different pH levels to compare the adhesion efficiency.
Results: The results showed that SCARB2 protein expressed from E. coli SHuffle® T7 Express with disulfide bond modifications had better adhesion to the viral capsid. Notably, when the medium pH was lowered to acidic levels, the binding efficiency of recombinant receptors to the viral capsid increased.
Conclusion: To our knowledge, this study reported for the first time the activity of SCARB2 under extreme pH conditions and also revealed the crucial role of disulfide bridges in the interaction with EV-A71’s capsid. This finding contributed to the strategy using recombinant SCARB2 as a viral trap.
Repellency Effects, Cytotoxicity Assessment and Chemical Compositions of Citrus limon Seeds Extracts and Fractions Against Anopheles gambiae sl Mosquitoes
Authors: Adeniyi-Akee Mukaram Akintunde , Mbachu Kingsley Adibe , Ibrahim Kolade , Osamudiamen Paul Matthew , Oluyemisi Aiyelaagbe Olapeju , Idowu Sunday Olakunle , Adegoke Olajire Aremu
Published: January 2025

Background: Citrus limon seeds have limited exploration, compared to other parts. The increasing prevalence of mosquito menace prompted the investigation into the repellent effects of the seed n-hexane extract and fractions of Citrus limon (Rutaceae) against adult Anopheles gambiae sl mosquitoes. The cytotoxicity and chemical constituents of the 100% n-Hexane Fraction (HF) were also evaluated.
Methods: Successive extraction was done with cold-maceration using, n-hexane, Ethyl Acetate (EA) and methanol. The three solvent extracts were screened against Anopheles gambiae sl mosquitos, using human bait method, at doses, 1.5, 2.5 and 5.0 mg/ml and with Deet and acetone used as positive and negative controls respectively. The n-hexane extract was further fractionated with column chromatography. Ten fractions (100% n-hexane, 10, 20, 30, 40, 60, 80% EA in n-hexane, 100% EA, 50% methanol in EA, and 100% methanol) were collected, and all tested at a single optimized dose of 5 mg/ml for 2 hr. The cytotoxicity and the chemical constituents of HF were determined using brine shrimp lethality test and gas chromatography-mass spectrometry respectively.
Results: N-hexane extract and HF, both at 5 mg/ml, showed the most protective effect of 97.52 and 89.40% respectively, compared with standard (Odomos Deet) 100% activity, with no significant difference (p>0.05) between the three. HF was toxic with LC50 values of 29.2354 ppm. Thirty compounds representing 79.25% of HF were identified. Major compounds present in the fraction were heptadecanamine (8.31%), N-(3-methylbutyl) acetamide (7.89%), 2-ethyl- 1-hexanamine (6.65%).
Conclusion: This promising repellent activity further justified the traditional usage of Citrus limon as mosquito repellent.
Ethical Considerations Emerge from Artificial Intelligence (AI) in Biotechnology
Authors: Dara Mahintaj , Azarpira Negar
Published: January 2025

The integration of Artificial intelligence (AI) in biotechnology presents significant ethical challenges that must be addressed to ensure responsible innovations. Key concerns include data privacy and security, as AI systems often handle sensitive genetic and health information, necessitating robust regulations to protect individuals' rights and maintain public trust. Algorithmic bias poses another critical issue; AI can reflect existing biases in training data, leading to inequitable healthcare outcomes. Transparency in AI decision-making is essential, as "black box" models hinder trust, especially in drug discovery and genetics. Ethical implications of genetic manipulation require careful scrutiny to define the limits of human intervention. Additionally, societal impacts must be considered to ensure equitable distribution of AI benefits, preventing the exacerbation of disparities. Engaging diverse stakeholders, including ethicists and policymakers, is vital in aligning these technologies with societal values. Ultimately, prioritizing ethics will allow us to harness AI and biotechnology's potential while safeguarding human rights and promoting equity.
Visualizing Type 2 Diabetes Prevalence: Localizing Model Feature Impacts
Authors: Sultan Youssef , Hammad Mohammad , Lester Kelly
Published: January 2025

SHAP values have been a common approach used to understand machine learning model predictions by averaging the marginal contributions of each feature across every possible permutation of the feature set. Our research provides a localized view of SHAP values contributing to Type 2 Diabetes (T2D) prevalence in the United States from 2012 - 2021 covering each year independently. Instead of visualizing SHAP feature importance across an entire geographical dataset using a beeswarm plot, our approach is more granular. We visualize individual SHAP values of Social Determinants of Health (SDOH) features by county on a Choropleth map. Additionally, we found that replacing geographic identifiers such as zipcode with precise latitude and longitude coordinates before applying KNN imputation reduced the MSE by 10%. Our visualization reveals how specific factors influence T2D prevalence at the county level using a non-linear machine learning model. By re-appending the initially preserved geographic identifiers for each record by index, we traced the contribution of each SHAP value back to its locality. Our approach opens up a new geographical vantage point of the mechanisms of model predictions, thereby identifying localized key factors influencing Type 2 Diabetes (T2D). This study extends the possibilities for tailored interventions and public health policies showing how some factors have varying predictive impact on an outcome at the geographic level.
Comparative Assessment of Nutritional, Industrial and Agronomic Valuable Traits of Underutilized Guar Genotypes
Authors: Sharma Sandhya , Tyagi Anshika , Ramakrishna G. , Saxena Swati , Mithra Amitha , Mehla H.R. , Golui Debasis , Sharma Ramavtar , Gaikwad Kishor
Published: January 2025

Background: Guar (Cyamopsis tetragonoloba), also known as cluster bean, is an annual legume with a high gum (galactomannan) content that is widely used in food, biopharmaceutical and other non-food industries. Despite the fact that several studies have been conducted to develop genomic resources for guar, information on its nutritional and other important biochemical profile is largely unknown. Method: In the present study, we investigated the extent of genetic variability of nutritional characteristics and gum content among different indigenous guar genotypes, as well as the correlation between them. A total of 40 guar genotypes were morphologically and biochemically characterized in order to be classified into nutritional and industrial usage groups. Result: Genotypes RGC-1055, RGR-7, RGC-1033, RGC-1002, RGC-1031, RGC-1038 and RGC-1055 were found to be superior for galactomannan, whereas genotypes HG-2-20, HG-258, HG-832, RGC-936, RGC-1066 and Pusa Navbahar were found to contain important quantitative traits such as a greater number of pods/cluster and clusters/plant, which is directly related to higher yield. Furthermore, correlation and PCA (principal component analysis) revealed that chlorophyll content is positively correlated with protein (0.2%) and gum content (0.16%). The data generated from this study could help breeders and biotechnologists for developing novel potential hybrids with desirable morphological, nutritional and industrial properties. Furthermore, enhanced crop quality may be achieved in the future by genetically modifying the nutritional and industrially significant targeted genes from the selected superior guar genotype using CRISPR/Cas9 precision gene editing technology.
Land Configuration and Nutrient Management on Yield and Nutrient Uptake of Green Gram under Sodic Soil
Authors: Anandhakrishnaveni S. , Karikalan N. , Roseleen S. Sheeba Joyce , Mailappa A.S.
Published: January 2025

Background: Pulses, endowed with unique ability of nitrogen fixation constitute an important component of crop diversification and resource conservation in farming systems. Green gram [Vigna radiate], a drought resistant crop, is one of the thirteen food legumes grown in India and the third most important pulse crop after chickpea and pigeon pea It is a protein rich staple food which contains about 25 percent protein and plays a crucial role in enhancing soil fertility through biological nitrogen fixation. Sodic soils typically exhibit poor nutrient availability as essential cations are displaced by sodium ions. They significantly influence green gram productivity, posing challenges to its sustainability, with the potential for sodification extending into subsoil layers, impeding plant root development and requiring remedial action. Appropriate land configuration and nutrient management could mitigating the challenges posed by sodic soils for pulse crops. Understanding the effects of land configuration and nutrient management on its growth, yield andeconomic viability is vital for sustainable agriculture. Keeping this in view, the field experiment was conducted to study the effect of different land configuration and nutrient management for their impact on plant height, dry matter production, grain yield, haulm yield, net income andBenefit Cost ratio with nutrient uptake under sodic condition. Methods: The land configuration factor consists of the three treatments viz., flat bed, ridges and furrows and broad bed furrow system. The second factor nutrient management comprising of five treatments like 100% RDF + 1% DAP, 100% RDF + 1% MAP, 75% RDF + 2% MAP, 100% RDF + 1% MKP, 75% RDF + 2% MKP. The RDF for green gram was 25 kg N + 50 kg P2O5 + 25 kg K2O per hectare. Result: Higher plant height, dry matter production, grain and haulm yield, protein yield, economic and nutrient uptake was recorded in broad bed furrow over farmer’s practice of flatbed method. N 4 - 100% RDF + 1% MKP foliar spray twice at (plant height, dry matter production, grain and haulm yield, protein yield, economic and nutrient uptake ) were observed than farmer’s practice. Hence, Broad bed furrow and nutrient management practice of 100% RDF + 1% MKP has the potential to enhance the productivity green gram under sodic condition.
Livelihood Responsibility Shifting to Migrant Worker Wives; A Reading of Qur’an and Hadith in Muslim Community
Authors: Khamim Khamim , Hijriyati Muthiah , Ansori Ibnu Hajar , Mohammad Hamsa Fauriz
Published: January 2025

This article aims to explore the shifting of livelihood (nafqa) responsibilities from husbands to wives in the contemporary context while looking at Muslim community’s reading on relevant Qur’an verses and hadith. Wives who work as migrant workers tend to serve as the main breadwinner in providing income in a household, including those from Kediri and Tulungagung, East Java. Livelihood itself is a common topic in the Islamic law discussion, mainly about who provide for whom and its quantity criteria.  Based on this problem, we portray the phenomenon and then present a reading of relevant Qur’anic verses and hadith within the community. The qualitative method was used by conducting interviews with husbands situated in that specific type of household. Data collection was also carried out by a review of relevant verses and hadith on family life followed by analytical approach using content analysis to identify how they are perceived by Muslim community. This study offers insights into Islamic family law in contemporary society, linking religious teachings to modern realities and providing a deeper understanding of this complex issue. The result shows that despite the phenomenon, the husbands still play their role as breadwinners, namely the secondary one. This stems from how they understand the rule of each family party, implying how religious teachings interplay with modern realities.