bluuebunny/crossref_metadata_2025 huggingface dataset:
Emergency intervention modes for ice jam events in large-scale water diversion projects
Authors: Xu Zepeng , Liu Mengkai , Guan Guanghua , Guo Xinlei
Published: September 2023

The formation of ice jams is sudden, and they will cause abnormal water level fluctuations in water diversion projects, affecting the water supply and even causing severe flood disasters. Based on the characteristics of the Middle Route of the South-to-North Water Diversion Project, this paper uses the numerical simulation method to establish an emergency intervention effect simulation model for ice jam events. The hydraulic response characteristics of the project under gate group scheduling and taking different emergency measures are analyzed with the water level deviation and stabilization time consumption of the pool as indicators. Moreover, this paper proposes an emergency intervention mode for ice jam events. The results show that using the gate group scheduling after ice jam events will cause a sharp rise in the upstream water level of the pool where the ice jams are located. Also, compared with other emergency measures, the electric heating ice melting measure has less influence on water level, and the de-icing effect is better. Finally, the emergency intervention mode can significantly reduce the maximum water level deviation and shorten the time required to stabilize the water level.
Uptake, accumulation, and degradation of dibutyl phthalate by three wetland plants
Authors: Fan Yaocheng , Li Tiancui , Zhang Zihan , Song Xiaoyong , Cun Deshou , Cui Baihui , Wang Yuewei
Published: September 2023

The uptake and degradation mechanisms of dibutyl phthalate (DBP) by three wetland plants, namely Lythrum salicaria, Thalia dealbata, and Canna indica, were studied using hydroponics. The results revealed that exposure to DBP at 0.5 mg/L had no significant effect on the growth of L. salicaria and C. indica but inhibited the growth of T. dealbata. After 28 days, DBP concentrations in the roots of L. salicaria, T. dealbata, and C. indica were 8.74, 5.67, and 5.46 mg/kg, respectively, compared to 2.03–3.95 mg/kg in stems and leaves. Mono-n-butyl phthalate concentrations in L. salicaria tissues were significantly higher than those in the other two plants at 23.1, 15.0, and 13.6 mg/kg in roots, stems, and leaves, respectively. The roots of L. salicaria also had the highest concentration of phthalic acid, reaching 2.45 mg/kg. Carboxylesterase, polyphenol oxidase, and superoxide dismutase may be the primary enzymes involved in DBP degradation in wetland plants. The activities of these three enzymes exhibited significant changes in plant tissues. The findings suggest L. salicaria as a potent plant for phytoremediation and use in constructed wetlands for the treatment of DBP-contaminated wastewater.
Мотивация студентов-психологов: роль контента масс медиа-психологов в ее формировании
Authors: Смирнова Нина В.
Published: September 2023

Введение. Данная статья посвящена исследованию влияния контента медиа-психологов на академическую мотивацию студентов-психологов. Исследование заполнит пробел в существующих научных знаниях, поскольку в данный момент мало известно об отношении студентов-психологов к просмотру психологического контента и о связи этого отношения с мотивацией. Методы. Выборка исследования составила 67 человек, из которых: 92,5% составили девушки, а 7,5% – мужчины. Применялись такие методики, как ШАМ (Шкала академической мотивации), САМОАЛ и авторская анкета-опросник. Результаты. Исследование показало высокую вовлеченность студентов-психологов в деятельность масс медиа-психологов. Большая часть из учащихся обозначает важность такого контента для развития критического мышления и профессиональных навыков в целом. Так же, было выявлено, что студенты часто обращающиеся к контенту масс медиа-психологов имеют более высокий уровень познавательной мотивации и креативности, по сравнению с теми, кто не интересуется таким контентом.  Обсуждение результатов. Полученные согласуются с исследованиями авторов, которые изучали особенности мотивации студентов-психологов и влияние медиа-контента на ее развитие. Исследование показало, что положительное влияние масс медиа-психологов на мотивацию студентов психологов действительно присутствует.
Cognitive apprenticeship in vocational students mathematical decision making skills
Authors: Oktaviyanthi Rina , Lestari Indri
Published: September 2023

Exploring the decision-making abilities of undergraduate students, including students from vocational education backgrounds, is the main priority in the achievement of mathematics learning in general and in Calculus courses particularly. Decision-making processes require cognitive guidance through activities describing in detail the systematic steps of each process. It is implicitly said as part of a cognitive apprenticeship procedure. There are claims that students with a vocational education background can develop their academic and practical potential more through a cognitive apprenticeship model. In addition, using video as visual media learning allows students to sharpen their skills. Therefore, the study aims to explore the distinction in achievement and improvement of mathematical decision-making skills between undergraduate students who learn with a Video-assisted Cognitive Apprenticeship approach (CAV), and they are who receive Cognitive Apprenticeship learning (CA) with conventional learning. A quantitative study with the Static-Group Pretest-Posttest Design was employed as a methodology in the research. Based on the research stage, there are differences in achievement and improvement of student decision-making skills with a review of the type of vocational school between undergraduate students.
Pulmonary Rehabilitation in Patients with Mechanical Ventilation: Bibliometric Analysis (Preprint)
Authors: Yin Jianing , Guan Xiaomin , Zhang Qi , Wang Wenjie , Chen Lan
Published: September 2023

BACKGROUND

Pulmonary rehabilitation has been widely used in patients with mechanical ventilation. However, in-depth bibliometric studies that measure and analyze scholarly publications worldwide are still rare.

OBJECTIVE

This study aims to characterize the publications in terms of countries, institutions, authors, journals, and collaboration relationships, and analyze the research trends of pulmonary rehabilitation in patients with mechanical ventilation.

METHODS

Publications regarding pulmonary rehabilitation in patients with mechanical ventilation were retrieved from the Web of Science core collection. To describe the contributions of the writers, journals, institutions, and nations, Microsoft Excel 2021 and VOSviewer were used. The trends, hot spots, and knowledge networks were analyzed by Citespace and VOSviewer.

RESULTS

A total of 968 articles and reviews between 2000 and 2022 were included. The number of annual publications grew steadily until 2019, after that, it got a dramatical increase in 2020 and 2022. The USA, Canada, and Italy were playing leading roles in this field. The top two major institutions with a larger number of publications were Queens University and the University of British Columbia. The author with the most output and citations was O'Donnell DE. The three fruitful journals were Journal of Applied Physiology, Respiratory Care, and Chest. Research hotspots have shifted over time in the following categories: the function of PR and targeted patients, which can be observed from the keyword analysis.

CONCLUSIONS

Research on pulmonary rehabilitation in patients with mechanical ventilation has progressed significantly over the past two decades. The United States, in particular, has made important contributions to this field. The research hotspot is gradually shifting in both outcomes and targeted patients of pulmonary rehabilitation.
Where are the Parents? The Drama of Youth Crime in the Media an Australian Focussed Discourse Analysis
Authors: Schulz Pamela D.
Published: September 2023

The language in media stories surrounding the high drama of juvenile and youth crime is very alarmist and continues to fuel political debates and demands for tougher penalties rather than the proverbial slap on the wrist for young offenders. Further there are fear discourse elements that suggest that for some politicians cited in the daily news cycle as being “out of control”. In opposition to this fear and alarmist discourse in the notion that the media news cycle highlights youth crime for its sensationalist perspectives and poor reporting of youth courts and their judgments in such matters. A comprehensive discourse analysis of youth crime reporting may suggest that media must take the blame for some of the inappropriate focus on youth crime as being selective. This yearlong study suggests that the public need more information to see for themselves whether the current moves and political debates need to be reviewed and refreshed. In addition, family supports are a signal to consider as presented by expert authorities involved in decision making and reporting.
The Severity of Schizophrenia
Authors: Mous Anony
Published: September 2023

Schizophrenia can be a severe condition was for many people but some cases can be particularly severe. My Psychiatrist put me in this category. What follows is an account of what this is like so we can gauge what people go through with the illness at its worst. This is followed by an account of what can help with even this and the ways the psychiatric system can help. Clinicians, friends and family should benefit from this as it provides hope even when the illness is at its worst.
Note on modified generalized Bessel function
Authors: Patel Farhatbanu H. , Jana R. K. , Shukla A. K.
Published: September 2023

An attempt is made to define Modified Generalized Bessel Function, and Modified Generalized Bessel Matrix Function. Some properties have also been discussed.
On universal realizability in the left half-plane
Authors: Alfaro Jaime H. , Soto Ricardo L.
Published: September 2023

A list Λ = {λ1, λ2,..., λn} of complex numbers is said to be realizable if it is the spectrum of a nonnegative matrix. Λ is said to be universally realizable (UR) if it is realizable for each possible Jordan canonical form allowed by Λ. In this paper, using companion matrices and applying a procedure by Šmigoc, we provide sufficient conditions for the universal realizability of left half-plane spectra, that is, spectra Λ = {λ1,...,λn} with λ1 > 0, Re λi ≤ 0, i = 2, . . . , n. It is also shown how the effect of adding a negative real number to a not UR left half-plane list of complex numbers, makes the new list UR, and a family of left half-plane lists that are UR is characterized.
Desapariciones forzadas – Desapariciones. La experiencia argentina - Implicancias subjetivas
Authors: Freier María
Published: September 2023

Este artículo expone la relevancia de la desaparición de personas en el contexto de la dictadura cívico militar en Argentina (1976-1983); describe el clima represivo, el plan sistemático de persecución,  secuestros y desapariciones sufridos por la sociedad argentina, la cual emprendió una resistencia y lucha, con el miedo y el dolor a cuestas; así como la importancia del activismo nacional e internacional para la judicialización de delitos de lesa humanidad. La autora escribe desde un pensamiento situado, como  hermana de una persona secuestrada-desaparecida en la dictadura de 1978; refiere la creación y consolidación de instituciones para el reconocimiento y búsqueda de desaparecidos y asistencia a las víctimas, así como la aplicación y desarrollo de la antropología forense en la investigación de violaciones a los derechos humanos como dos factores que han contribuido a la construcción de la memoria histórica social y subjetiva de este flagelo en Argentina.
Arqueología marítima forense: pensamiento crítico, teoría y geofísica marina como herramientas clave para la búsqueda de personas desaparecidas en contextos sumergidos
Authors: Herrera Jorge M. , Gómez Goyzueta Fernando , Jiménez Pamela
Published: September 2023

Este artículo discute las consideraciones teóricas, metodológicas y de instrumentación con las que es posible y necesario trabajar para auxiliar en la detección de restos humanos en contextos sumergidos de una manera científica, sistemática, y reproducible. Esta labor es también copartícipe del propósito de hacer de la arqueología una herramienta para ayudar a cerrar procesos profundamente dolorosos entre las familias que han sufrido pérdidas en el grave contexto de desapariciones forzadas en el México actual. Se consideran como parte del análisis los siguientes elementos clave: 1) la necesidad de un desarrollo explícitamente teórico en arqueología que incorpora estrategias para la resolución de preguntas, tal como es el caso de la arqueología procesual; 2) el análisis de las alteraciones tafonómicas que afectarán a un cuerpo humano y que se presentan en el escenario de un contexto sumergido, y, 3) el desarrollo de una metodología de prospección que incorpora tecnologías de punta de lanza en la arqueología marítima contemporánea, con énfasis en instrumentación de posicionamiento, geofísica marina, fotogrametría, robótica y buceo técnico y científico.
Algunos puntos centrales para la enseñanza de la matemática en el bachillerato
Authors: Santos Trigo Luz Manuel
Published: September 2023

En este video se destaca la necesidad de trabajar la matemática de forma contextualizada, ligada al entorno de los estudiantes, así como la conveniencia de que cuente con diagnósticos y la explicación de conceptos fundamentales. Se señala la relevancia de que los estudiantes exploren otras formas de llegar a la solución de los problemas y de que se apoyen en la tecnología. A modo de ejemplo de la implementación de estos puntos, se presenta un desarrollo dentro del CINVESTAV para UNICEF que incluye también el uso de herramientas diversas de evaluación y de recursos digitales, como las plataformas.
Utilization of Conventional and Non-Conventional Energy Sources
Authors: Bharda Dhaval A. , Dixit Rohit
Published: September 2023

Abstract: A teenager and environmental - social worker of Sweden GRETA THUNBERG presented her views on the transformation of hydro energy in August 2018 at the UNITED NATION ORGANISATION which shocked everyone wherein she made the school declare holidays to the students in Sweden and enlightened them for the preservation of the environment and expressed that if the quantum of carbon dioxide is not reduced in the world then the world will have to face serious consequences. In this paper, the author has included essential data on specific conditions due to environmental events. The work has been taken around many kinds of research made about ecological studies.
A Review on the Prospects Engineering Management
Authors: Jagtap Aarti , Jaiswal Dr. Rupesh C.
Published: September 2023

Abstract: Engineering Management seems like a prime opportunity for students who have potent technical skills and wish to develop their abilities to enter the business world. This research paper explores the present trend in engineering management, highlighting the challenges encountered, opportunities for Engineering Management in the future, the benefits of attaining a master's degree, as well as other factors including competencies and skills. It aims to provide a solid framework for engineering graduates who wish to be engineering managers. It is motivated by thorough analysis, factual research, and useful case studies.
Inteligencia artificial, investigación y revisión por pares: escenarios futuros y estrategias de acción
Authors: Cárdenas Julián
Published: September 2023

La inteligencia artificial (IA) está revolucionando la investigación y el mundo académico, facilitando desde la redacción del manuscrito hasta el análisis de datos. Pero, la IA no “pisa la calle”. La IA sigue confinada al ámbito digital y es incapaz de involucrarse en interacciones humanas para indagar sobre dinámicas interpersonales o comprender el contexto. Ante este panorama, ¿se debería aceptar que la IA revise artículos de investigación enviados a una revista? ¿Cómo debe adaptarse la academia ante el auge de la IA generativa? El presente artículo reflexiona sobre el impacto de la IA en la investigación y el mundo académico, ofreciendo una definición y caracterización de la IA generativa, presentando herramientas de IA que asisten en la investigación, y analizando cuatro escenarios futuros posibles: democratización de la investigación, desaprovechamiento de la IA, aumento de la desigualdad y rezagados digitales. Se concluye sugiriendo estrategias de acción como mayor formación en herramientas de IA, fomento de una educación basada en investigación, y necesidad de abrir un debate sobre el uso de la IA en la gestión de las revistas científicas.
Arquitectura del bienestar en la Ciudad Autónoma de Buenos Aires: Diálogos con la desigualdad urbana
Authors: Di Virgilio María Mercedes , Serrati Pablo Santiago
Published: September 2023

La vida cotidiana de los grupos de menores ingresos en las sociedades capitalistas y, por ende, su inserción en la ciudad se estructura en relación con una amplia gama de intervenciones estatales. Dichas intervenciones se articulan en el sistema general que define la arquitectura del bienestar y colaboran en el desarrollo de entornos urbanos más o menos solidarios e igualitarios. A través de la provisión de infraestructuras, servicios y equipamientos, el Estado se constituye en un importante motor de estratificación y diferenciación socio-territorial. El trabajo indaga cómo el acceso a los recursos urbanos impacta en la producción de desigualdades socioespaciales en la Ciudad de Buenos Aires. A este fin, recurre a diferentes fuentes de datos sobre infraestructuras y servicios de la Ciudad de Buenos Aires. Estas fuentes son utilizadas de modo combinado mediante un análisis cuantitativo que integra diferentes técnicas estadísticas. Asimismo, recurre a entrevistas con informantes clave que permiten comprender mejor cómo operan los recursos públicos en el acceso al bienestar y cuál es el papel de las redes sociales de base territorial en ese contexto. El trabajo identifica seis espacios diferenciados en relación al acceso al bienestar, reproduciendo en gran medida el patrón de desigualdades preexistentes. En ese escenario, la pandemia produjo efectos contradictorios. Por un lado, le otorgó mayor peso a las relaciones de proximidad y provocó un redescubrimiento del entorno barrial. Por el otro, al acentuar el peso de dichos espacios acentuó las desigualdades en el acceso al bienestar.
Integral formula for quantum relative entropy implies data processing inequality
Authors: Frenkel Péter E.
Published: September 2023

Integral representations of quantum relative entropy, and of the directional second and higher order derivatives of von Neumann entropy, are established, and used to give simple proofs of fundamental, known data processing inequalities: the Holevo bound on the quantity of information transmitted by a quantum communication channel, and, much more generally, the monotonicity of quantum relative entropy under trace-preserving positive linear maps – complete positivity of the map need not be assumed. The latter result was first proved by Müller-Hermes and Reeb, based on work of Beigi. For a simple application of such monotonicities, we consider any `divergence' that is non-increasing under quantum measurements, such as the concavity of von Neumann entropy, or various known quantum divergences. An elegant argument due to Hiai, Ohya, and Tsukada is used to show that the infimum of such a `divergence' on pairs of quantum states with prescribed trace distance is the same as the corresponding infimum on pairs of binary classical states. Applications of the new integral formulae to the general probabilistic model of information theory, and a related integral formula for the classical Rényi divergence, are also discussed.
The Round Complexity of Local Operations and Classical Communication (LOCC) in Random-Party Entanglement Distillation
Authors: Liu Guangkuo , George Ian , Chitambar Eric
Published: September 2023

A powerful operational paradigm for distributed quantum information processing involves manipulating pre-shared entanglement by local operations and classical communication (LOCC). The LOCC round complexity of a given task describes how many rounds of classical communication are needed to complete the task. Despite some results separating one-round versus two-round protocols, very little is known about higher round complexities. In this paper, we revisit the task of one-shot random-party entanglement distillation as a way to highlight some interesting features of LOCC round complexity. We first show that for random-party distillation in three qubits, the number of communication rounds needed in an optimal protocol depends on the entanglement measure used; for the same fixed state some entanglement measures need only two rounds to maximize whereas others need an unbounded number of rounds. In doing so, we construct a family of LOCC instruments that require an unbounded number of rounds to implement. We then prove explicit tight lower bounds on the LOCC round number as a function of distillation success probability. Our calculations show that the original W-state random distillation protocol by Fortescue and Lo is essentially optimal in terms of round complexity.
Performance of The Composite Electrode of Reduced Graphene Oxide Palm Oil Shell - Zinc Oxide (rGOCKS - ZnO) as a Chemical Oxygen Demand (COD) Sensor by Photoelectrocatalysis
Authors: Azis Thamrin , Muzakkari Muhammad Z. , Nurdin Muh. , Maulidiyah Maulidiyah , Muslia Wa O. , Bijang Catherina M. , Tahril Tahril
Published: September 2023

The preparation of reduced graphene oxide composite electrodes from palm shells (rGOCKS-ZnO) as a chemical oxygen demand (COD) sensor by photoelectrocatalysis has been successfully carried out. The preparation of rGOPS - ZnO electrodes by thermal reduction method and modified Hummer. The XRD results showed several peaks of rGOCKS - ZnO namely 23.287 º, 26.781 °, 29.889 °, 32.468 °, 35.109 °, 37.14 °, 39.822 °, 43.559 °, 47.927 °, and 48.537 °. SEM-EDX analysis reveals the surface of graphene sheets containing aggregates in the shape of small particles attached to graphene sheets. The results of the EDX analysis consisted of C 67.82 %, O. 19.2 %, Zn. 7.85 % and 5.13 % impurity. The CV and LSV tests showed that the rGOAK - ZnO electrode with a variation of 1 gram: 0.3 gram had a good response to the oxidation process under visible light. The profile tests of these organic dyes (methylene blue) in concentrations of 0.5 ppm, 1.0 ppm, 2.0 ppm, and 3.0 ppm were applied by Multi Pulse Amperometry (MPA). The performance of the rGOPS - ZnO electrode has been in determining the value of COD by photo electrocatalytic good sensitivity, linearity, limit of detection, repeatability, and service life. The COD value was determined using the rGOPS - ZnO electrode and obtained 2.97897 mg/LO2 close to the theoretical value.
Synthesis of Silver Nanoparticles using Gandaria Seeds Bioreductor
Authors: Bijang Catherina M. , Hasanela Nurani , Joris Shielda N. , Fransina Eirene G. , Tahril Tahril , Azis Thamrin , Tehuayo Ahmadin
Published: September 2023

The silver nanoparticles (NPP) are synthesized with the chemical reduction method by using a water extract bioreductor of gandaria seed (Bouea macrophylla G.) which acts as a reducing precursor, in this case, AgNO3 Ag+ is reduced to AgO. The concentration of AgNO3 is made between 0.5 mm and 1 mm. The characteristic of NPP is unstable, so a modification is needed with and without the addition of PVA 1 %. The process of NPP shaping is monitored by observing the uptaken of UV - Vis when the color changes occur. The high NPP concentration of AgNO3 has higher absorbance and is wider if compared to the lower AgNO3 concentration. The result of this research based on the absorbance value and the wavelength showed the NPP synthesized without the addition of PVA 1 % (b/v) is wider. The addition of PVA 1 % (b/v) provides better stability and maintains the absorbance of spectrum changes from day to day. The maximum uptaken of UV-Vis from NPP AgNO3 0.5 mm by using green synthesis and 1 mm without adding PVA are 0.946 and 0.980, respectively. However, NPP with the addition of PVA has 0.968 and 0.978 absorbance. The best concentration of NPP produced was 1 mm AgNO3.
Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to Cancer Therapeutics
Authors: Kumar Manish
Published: September 2023

Cancer is a complex disease having a number of composite problems to be
considered including cancer immune evasion, therapy resistance, and
recurrence for a cure. Fundamentally, it remains a genetic disease as
diverse aspects of the complexity of tumor growth and cancer development
relate to its genetic machinery and require addressing the problems at
the level of genome and epigenome. Importantly, patients with the same
cancer types respond differently to cancer therapies indicating the need
for patient-specific treatment options. Precision oncology is a form of
cancer therapy that focuses on the genetic profiling of tumors to
identify molecular alterations involved in cancer development for
custom-tailored personalized treatment of the deadly disease. This
article aims to briefly explain the foundations and frontiers of
precision oncology in the context of ongoing technological advances in
this regard to assess its scope and importance in the realization of a
proper cure for cancer.
Connectivity and short-term flood interactively affect fish community composition in drainage ditches of paddy fields in an agricultural landscape
Authors: Iwamoto Hideyuki , Tahara Daisuke , Yoshida Takehito
Published: September 2023

Community assembly can change over time following variations in
connectivity among habitats. Previous studies have demonstrated the
influence of seasonal pulse floods on community structures by
facilitating species dispersal, but the effects of short-term flash
floods have been poorly investigated. We investigated fish community
structures before and after a short-term flood in drainage ditches of
paddy fields in the Kita River basin, Japan. The study sites were
classified into three connectivity types, “Transient” (connected only
during the flood, with a temporally-disappearing vertical gap between
drainage ditches and downstream rivers), “Connected” (always
connected, without the vertical gap), and “Disconnected” (always not
connected, with the vertical gap). The abundance of Misgurnus
anguillicaudatus, the only species that dispersed from paddy fields to
drainage ditches, increased after the flood irrespective of the
connectivity types, although the total abundance of the other species
significantly increased after the flood only in the “Transient” sites.
The dissimilarity of species composition between the (n-1)-th and n-th
surveys at each site was consistently low in the “Connected” and
“Disconnected” sites, whereas it rose just after the flood and
gradually declined in the “Transient” sites. Species composition was
significantly different among the connectivity types, indicating that
some fish species need stable connectivity even during the non-flood
period. The results showed that the short-term flood facilitated fish
dispersal from paddy fields by the increased water discharge and that
from downstream rivers by the temporary removal of vertical gap,
emphasizing the importance of hydrological connectivity for biodiversity
conservation in an agricultural landscape.
EPPTA: Efficient Partially Observable Reinforcement Learning Agent for Penetration testing Applications
Authors: Li Zegang , Zhang Qian , Yang Guangwen
Published: September 2023

In recent years, penetration testing (pen-testing) has emerged as a
crucial process for evaluating the security level of network
infrastructures by simulating real-world cyber-attacks. Automating
pen-testing through reinforcement learning (RL) facilitates more
frequent assessments, minimizes human effort, and enhances scalability.
However, real-world pen-testing tasks often involve incomplete knowledge
of the target network system. Effectively managing the intrinsic
uncertainties via partially observable Markov decision processes
(POMDPs) constitutes a persistent challenge within the realm of
pen-testing. Furthermore, RL agents are compelled to formulate intricate
strategies to contend with the challenges posed by partially observable
environments, thereby engendering augmented computational and temporal
expenditures. To address these issues, this study introduces EPPTA
(Efficient POMDP-Driven Penetration Testing Agent), an agent built on an
asynchronous RL framework, designed for conducting pen-testing tasks
within partially observable environments. We incorporate an implicit
belief module in EPPTA, grounded on the belief update formula of the
traditional POMDP model, which represents the agent’s probabilistic
estimation of the current environment state. Furthermore, by integrating
the algorithm with the high-performance RL framework, Sample Factory,
EPPTA significantly reduces convergence time compared to existing
pen-testing methods, resulting in an approximately 20-fold acceleration.
Empirical results across various pen-testing scenarios validate EPPTA’s
superior task reward performance and enhanced scalability, providing
substantial support for efficient and advanced evaluation of network
infrastructure security.
Biased agonists of GPR84 and insights into biological control
Authors: Luscombe Vincent , Wang Pinqi , Russell Angela , Greaves David
Published: September 2023

GPR84 was first identified as an open reading frame encoding an orphan
Class A G protein coupled receptor in 2001. Gpr84 mRNA is expressed in a
limited number of cell types with the highest levels of expression being
in innate immune cells, M1 polarised macrophages and neutrophils. The
first reported ligands for this receptor were medium chain fatty acids
with chain lengths between 9 and 12 carbons. Subsequently a series of
synthetic agonists that signal via the GPR84 receptor were identified.
Radioligand binding assays and molecular modelling with site-directed
mutagenesis suggest the presence of three ligand binding sites on the
receptor, but the physiological agonist(s) of the receptor remain
unidentified. Here, we review the effects of GPR84 agonists on innate
immune cells following a series of chemical discoveries since 2001. The
development of highly biased agonists has helped to probe receptor
function in vitro, and the challenge remaining is to follow the effects
of biased signalling to the physiological functions of innate immune
cell types.
Improvement of an enzymatic cascade synthesis of nicotinamide mononucleotide via protein engineering and reaction-process reinforcement
Authors: Peng Feng , Hong Jian , Cui Jie , An Ya-Ni , Guo Qian , shen qi , Cheng Feng , Xue Ya-Ping , Zheng Yu-Guo
Published: September 2023

Enzymatic synthesis of β-Nicotinamide mononucleotide (NMN) has garnered
widespread attention due to its advantages of minimal environmental
impact, the use of mild reaction conditions, and the ability to produce
highly pure products with the desired optical properties. However, the
overall NMN yield of enzymatic synthesis, which begins with ribose and
niacinamide, is impeded by the low activity of rate-limiting enzymes. In
this study, the enzymes that control the rate of the reaction,
ribose-phosphate diphosphokinase (PRS) and nicotinamide
phosphoribosyltransferase (NAMPT), were engineered to improve the
reaction efficacy. The actives of single mutants PRS-H150Q and
NAMPT-Y15S were 4.34 times and 1.57 times that of their corresponding
wild type enzymes, respectively. Furthermore, the byproduct
pyrophosphate, which can inhibit NAMPT, was degraded by pyrophosphatase
(PPase), leading to a 6.72% increase in NMN yield. Following with
reaction-process reinforcement, a yield of 8.10 g/L NMN was obtained
from 3.64 g/L NAM after 3 hours of reaction, which was 56.86-fold higher
than that of the stepwise reaction synthesis (0.14 g/L), indicating that
the in vitro enzymatic synthesis of NMN from ribose and niacinamide is
an economical and feasible route.
Morphometry of FEMALE Reproductive Organs of Rose- Ringed Parakeet (Psittacula krameri) in Breeding and non-breeding Seasons
Authors: Rasheed Asadullah , Rehan Sarmad , Qureshi Anas Sarwar , Hussain Riaz
Published: September 2023

The reproductive organs of rose-ringed parakeet (n= 6) were studied in
detail in this research work during breeding (December to April) and
non-breeding (May to November) seasons. After slaughtering, organs of
the reproductive system were collected for anatomical and histological
study. The right ovary and oviduct were absent, the left ovary and
oviduct were collected to record weight and dimensions (width, length,
diameter, and volume). The results showed a higher weight (1.08±0.116 g)
of the left ovary during the breeding and a decreased (0.069±0.015 g) in
the non-breeding season (P< 0.05). The length of the left
ovary during the breeding and non-breeding season was recorded as
(6.59±0.20 mm) and (5.75±0.12 mm). The width of the left ovary during
the breeding season and in non-breeding was recorded as (5.86±0.09 mm)
and (3.76±0.18 mm). The results showed maximum volume (0.05±0.003
cm) during the breeding season and a decrease in
volume (0.03±0.003 cm) in the non-breeding season in
the left ovary. A higher weight (1.21±0.13 g) of the left oviduct during
the breeding and a decreased (0.08±0.016 g) in the non-breeding season
was observed. The length of the oviduct during the breeding season was
(33.21±0.14 mm) and during non-breeding season as (30.23±0.29 mm). The
width of oviduct during breeding season was recorded as (1.12±0.01 mm)
and during in non-breeding season as (0.83±0.03 mm), respectively.
Thus, the ovary and oviduct have higher weights and dimensions during
the breeding season that correspond to breeding activity.
Water Mass Transformations Within Antarctic Coastal Polynyas of Prydz Bay from Clustered Drifters
Authors: Murakami Margaret , Nummelin Aleksi , Galton-Fenzi Benjamin Keith , Uotila Petteri
Published: September 2023

Antarctic Bottom Water (AABW) forms the deepest limb of the meridional
overturning circulation (MOC) and is a key control on global exchanges
of heat, freshwater, and carbon. Density differences that drive the MOC
have their origin, in part, in coastal polynyas. Prydz Bay polynyas in
East Antarctica are a key source of Dense Shelf Water (DSW) that feeds
AABW to the Atlantic and Indian Oceans. However, several poorly
understood mechanisms influence the pathways and change water mass
properties of the DSW on its way to the abyss. To better understand
these mechanisms, we release Lagrangian particles in a 10 km resolution
simulation of the Whole Antarctic Ocean Model and analyze the resulting
tracks using novel cluster analysis. Our results highlight the role of
mixing with other water masses on the shelf in controlling the fate of
DSW and its eventual contribution to AABW. When advected beneath the ice
shelf, DSW can mix with fresh Ice Shelf Water (ISW), becoming less dense
and making future AABW formation less likely. This study confirms that
towards the shelf break along the Antarctic Slope Current, mixing with
circumpolar deep water (CDW) forms modified circumpolar deep water
(mCDW) and influences DSW export as AABW. Our findings indicate that the
pathway from DSW to AABW is sensitive to mixing with ambient waters on
the shelf. An important implication is that with future increase in ice
shelf melt and CDW warming, AABW production is likely to decline, even
if DSW production in coastal polynyas remains constant.
Manufacturing of the stainless-steel sheathed magnesium diboride superconductor wire
Authors: Yudanto Sigit , Affandi Ahmad , Manaf Azwar
Published: September 2023

The Powder in Tube (PIT) method was utilized to manufacture the MgB2-based monofilament wire. The ground powders of Mg and B were filled in the stainless-steel tube and went through a cold-rolling process. In order to avoid oxidation, the wire was cut and packed into the stainless-steel tube before sintering at various temperatures (873, 973, and 1073 K). We offer this heating process in a tube as a method that was both practical and efficient. The formation of the MgB2 phase was analyzed using an X-ray diffractometer post-sintering. At the sintering temperature of 973 K, the MgB2 phase was formed which contained small amounts of magnesium oxide. The sample sintered at 973 K showed superconducting properties, with a critical temperature zero (Tc-zero) and onset (Tc-onset) of 34.09 K and 41.33 K, respectively. A large gap between Tc-onset and Tc-zero was indicated by the insufficient fraction of the MgB2 phase that formed. However, MgB2-based superconducting wire was successfully manufactured in the required tube utilizing a vacuum-free heating process and only a small amount of magnesium oxide.
Effect of Cr limits on microstructure and mechanical properties of P/M 316l austenitic steel
Authors: Erden Mehmet , Demirtaş Hüseyin , Oleiwi Fadhil
Published: September 2023

This study investigated the effect of the Cr limits on the microstructure and mechanical properties of 316L alloy. Five 316L alloys with varying Cr contents (16.8, 17.1, 17.3, 17.8 and 18.8 wt.%) were produced by the powder metallurgy (P/M) method. Microstructure studies and phase analysis were performed with a scanning electron microscope (SEM), optical microscopy (OM), and energy dispersive spectrometry (EDS). Tensile tests and hardness measurements were performed to evaluate the hardness, strength, and ductility of the alloys. The results showed that Cr addition affected the porosity and grain size of the alloys, as well as the formation of precipitates. The ultimate tensile strength reached a maximum at 17.3 wt.% Cr and then decreased with further Cr addition. Ductility decreased with increasing Cr under the influence of precipitates formed and changes in microstructure. On the other hand, the hardness increased with increasing Cr inversely to the ductility.
INDUSTRIA 4.0 IMPACTA LA LOGISTICA INVERSA
Authors: Velásquez Monroy Xiomara Daniela
Published: September 2023

El creciente enfoque en el desarrollo sostenible, la economía circular y regulaciones ambientales más estrictas han requerido que las empresas y organizaciones que integran las cadenas de suministro asuman la responsabilidad de todo el ciclo de vida de sus productos. Esto, con el objeto de maximizar la recuperación del valor restante de los productos al final de su uso y de su vida útil, a través del diseño, operación, control, y mantenimiento económico y eficientemente del flujo logístico inverso de sus productos, desde los clientes hacia fabricantes y proveedores iniciales, con el apoyo de operaciones logísticas de recolección y reciclaje con el objeto de preservar el valor y la utilidad de los materiales en el mayor tiempo posible, generando ganancias significativas en la cadena de valor. Sin embargo, la logística inversa tradicional no puede hacer frente a los requisitos de las cadenas de suministros modernas y requiere la implementación de tecnologías disruptivas de la Industria 4.0, lo que la haría más eficiente, con procesos de redistribución más limpios, con objetivos de sostenibilidad afines a la economía circular. Las tecnologías disruptivas de la industria 4.0 conducen a mejoras de la sostenibilidad empresarial e introducen importantes soluciones innovadoras en la logística inversa.
Experiencing a Lament Performance in a Mire
Authors: Latvala-Harvilahti Pauliina
Published: September 2023

The article addresses the topical issue of environmental emotions from the perspective of individual experiences of environmental art reception. The research focuses on how the audience experienced lament performances by singer and musician Noora Kauppila in natural mires in Finland, and it asks the research question: What kinds of environmental emotions have laments in the mire provoked, and how are emotions contextualised in audience interviews? Art performances in the mire have become part of a growing international mire trend in the 21st century. I understand mires as a living heritage that reflects the diversity and inter-connectedness of heritage elements (e.g. practices and knowledge concerning nature) experienced by community members and individuals. The effectiveness of art (lament performances) is linked to reception research, which has not previously been applied to mire art performances. In the debate on the impact of art, the experiential perspective has been marginal. In the interview material, individuals’ experiences reveal strong emotions about the endangered environment. The lament performance transformed a mire into a culturally appropriated space for the collective and individual processing of emotions regarding a fragile natural environment. The interviewees reported unwanted changes in their own surroundings, and their feelings about the changes were reflected in the observed decline in the habitats of birds and other mire animals. In a broad sense, the article offers insights into the meanings and changes of an individual’s relationship with nature. The research evidence suggests that a communal context is needed to deal with environmental emotions, especially negative emotions like sorrow, hatred and grief. Likewise, the individual accounts reveal a need for a communal change in abandoning unsustainable lifestyles. The article is based on research that has been undertaken as part of the ‘Mire Trend’ research project at the University of Eastern Finland.
OPERATING CONDITIONS OF THE FENTON PROCESS ON THE HERBICIDE ATRAZINE DEGRADATION IN WASTEWATERS
Authors: Fittipaldi Correa Camila , SANTOS DE OLIVEIRA LOURENÇO EDNEIA , Ferreira Tavares Maria Herminia , Fleck Leandro
Published: September 2023

Este estudo investigou os efeitos das condições operacionais do processo Fenton na degradação do herbicida atrazina em águas residuárias. Propôs-se um delineamento composto central rotacional (DCCR) 2², cobrindo 11 ensaios, com os seguintes fatores: a concentração de Fe2+ (2,95; 5,00; 10,00; 15,00; 17,05 mgL-1) e a concentração de H2O2 (29,50; 50,00; 100,00; 150,00 e 170,50 mgL-1). Estes fatores foram otimizados com base nos valores da degradação da atrazina, com tempo de tratamento de 30 minutos e medidas realizadas através de Cromatografia Líquida de Alta Eficiência. Para determinar as condições ótimas de operação do processo, os resultados foram estudados pela análise de variância (ANOVA) através dos efeitos dos dois fatores e suas possíveis ações combinadas, seguindo-se a metodologia da superfície de resposta. Assim, as condições ótimas de operação do processo foram: concentração de Fe2+ = 17,05 mgL-1 e de H2O2 = 128 mgL-1. Nestas condições, o processo mostrou-se promissor, alcançando valores de 91,00% de degradação da atrazina aos 30,0 min. de tratamento, apresentando-se como uma alternativa eficiente a ser usada como polimento final.
PENGARUH PROFITABILITAS DAN UKURAN PERUSAHAAN TERHADAP NILAI PERUSAHAAN DENGAN CORPORATE SOCIAL RESPONSIBILITY SEBAGAI VARIABEL MODERASI
Authors: Kharisma Putri , Priyadi Maswar Patuh
Published: September 2023

Penelitian ini dilakukan dengan tujuan untuk menguji: 1) pengaruh profitabilitas terhadap nilai perusahaan; 2) pengaruh ukuran perusahaan terhadap nilai perusahaan; 3) Corporate Social Responsibility (CSR) dapat memoderasi pengaruh profitabilitas terhadap nilai perusahaan; 4) Corporate Social Responsibility (CSR) dapat memoderasi pengaruh ukuran perusahaan terhadap nilai perusahaan. Populasi yang digunakan adalah perusahaan sektor healthcare (kesehatan) yang terdaftar di Bursa Efek Indonesia (BEI) pada tahun 2017-2021. Teknik yang digunakan dalam penelitian ini adalah teknik purposive sampling, sehingga terdapat 18 perusahaan dari 23 perusahaan yang sesuai kriteria dan data yang diobservasi sebanyak 90 sampel. Metode analisis data menggunakan analisis linear berganda dengan menggunakan SPSS versi 26. Hasil penelitian menunjukkan bahwa: 1) profitabilitas berpengaruh positif terhadap nilai perusahaan; 2) ukuran perusahaan tidak berpengaruh terhadap nilai perusahaan; 3) Corporate Social Responsibility (CSR) dapat memoderasi pengaruh profitabilitas terhadap nilai perusahaan; 4) Corporate Social Responsibility (CSR) dapat memoderasi pengaruh ukuran perusahaan terhadap nilai perusahaan.
Kontribusi Sektor Pariwisata Terhadap Pendapatan Asli Daerah Kota Bukittinggi
Authors: Pratama Kevin Putra , Ariusni Ariusni , Artha Dwirani Puspa
Published: September 2023

This study aims to analyze how big the contribution of revenue growth from the Tourism Sector to Regional Original Income (PAD) in the City of Bukittinggi, as well as to determine the development trend of the tourism sector in the City of Bukittinggi in the 2010-2030 period. This research includes descriptive and associative research with a quantitative approach using secondary data obtained from the Tourism, Youth and Sports Office and the Central Bureau of Statistics for the City of Bukittinggi. The analysis used in this research is proportionality analysis and trend analysis . The highest contribution results show in 2010 of 38% while the lowest shows in 2020 of 23%. Meanwhile, the results of forecasting the income of the tourism sector in this study show that from 2021-2030 the highest figure will be in 2030 of IDR 55,293,321,325
Efectos del hidrogel polietilenglicol diacrilato quitosano sobre la evolución de herida traumática en ratones CD1 sanos y diabéticos
Authors:   Facultad de Medicina, Universidad Autónoma del Estado de México, Bárcenas García Angel Eduardo , Flores- Merino Miriam V ,   Centro de Investigación en Ciencias Médicas, Universidad Autónoma del Estado de México, Oros Pantja Rigoberto ,   Facultad de Medicina, Universidad Autónoma del Estado de México
Published: September 2023

Debido a su elevada tasa de morbi-mortalidad, la Diabetes Mellitus (DM) se considera un serio problema de salud pública en México y a nivel global 1. Dentro de sus múltiples complicaciones, el daño microvascular y neuropático crónico se considera un factor riesgo para el desarrollo de ulceras diabéticas. La pérdida en la continuidad de la epidermis y de estructuras anatómicas profundas, a su vez puede representar un mayor riesgo en los pacientes. Por tanto, las terapias que permitan acelerar el cierre de heridas, podrían mejorar la calidad de vida de los pacientes e influir considerablemente sobre el impacto económico que representa su tratamiento. En el presente estudio, se evaluó la evolución de heridas traumáticas a través de la aplicación de pellets de hidrogel polietilenglicol diacrilato quitosano (PEGDA-Q) en ratones CD1 sanos y diabéticos. Tras un periodo de 10 días de evolución, se realizó descripción y documentación de imágenes macroscópicas y microscópicas, en las cuales se analizaron los cambios sobre los procesos cicatriciales. Resultados: el tratamiento con PEGDA-Q demostró ser un material biocompatible in-vivo. En el análisis histopatológico, los ratones controles tratados con PEGDA-Q, el grado de reepitelización fue del 100%, mientras que en las lesiones sin hidrogel, la consolidación fue del 50%. En relación a los ratones diabéticos, las lesiones con PEGDA-Q, la consolidación de la herida y de la reepitelización fue del 70%, mientras que en las lesiones sin tratamiento fue del 40%. El tratamiento con hidrogel, aceleró el proceso de reparación tanto en los animales sanos como los diabéticos. Por tanto podría ser una alternativa viable para el tratamiento de lesiones traumáticas de etiología múltiple. Este estudio, podría ser un punto de partida para su posible aplicación en el área clínica. Así mismo, el hidrogel podría ser un vehículo para el tratamiento conjunto con la impregnación de células madre y la liberación prolongada de múltiples fármacos.