bluuebunny/crossref_metadata_2025 huggingface dataset:
Blood Flow Restriction Training for Subacromial Pain: Two Case Reports
Authors: Miller Matthew , Zeppieri Giorgio , Farmer Kevin W. , Pozzi Federico
Published: June 2024

Background

Blood flow restriction training (BFRT) appears to promote the strengthening of shoulder muscles, but primary clinical applications are limited to the lower extremity.

Case Presentation

Two female recreational athletes (Case A: 27 years old; Case B: 28 years old) with subacromial pain were treated with BFRT (50% occlusion) during 3 isotonic strengthening exercises of the upper extremity against 20% of the maximal isometric strength. At the beginning of each treatment week, we measured strength with a handheld dynamometer to ensure appropriate load progression.

Outcome and Follow-Up

Case A completed 16 visits and Case B completed 22 visits of BFRT with no adverse events. At discharge, we found meaningful improvement for patient-reported function, clinical measures of shoulder flexion and external-rotation range of motion and isometric strength, supraspinatus and infraspinatus cross-sectional area, and upper extremity performance.

Discussion

BFRT may be a valuable adjunct to standard rehabilitation for the conservative management of subacromial pain. Despite the inherent limitations of our design, we believe these preliminary findings are compelling to warrant future investigations. JOSPT Cases 2022;2(2):55–61. doi:10.2519/josptcases.2022.10867
Electrophysiological Evaluation of a Patient With Chronic Erb-Duchenne Palsy (C5-C6): A Case Study
Authors: Greathouse David G. , Painter Elizabeth E.
Published: June 2024

Background

Erb-Duchenne palsy describes injury to the upper trunk of the brachial plexus or the C5 and C6 nerve roots. It typically occurs from a traction injury that increases the angle between the head and shoulder girdle, placing excessive strain on the cervical nerve roots and brachial plexus. Injury to the C5 and C6 nerve roots and/or upper trunk of the brachial plexus results in severe shoulder girdle weakness with preservation of the hand intrinsic muscles and some forearm motions. 2 , 9

Case Presentation

A 64-year-old right-hand–dominant male was referred by his orthopaedic surgeon for electromyograhy (EMG) and nerve conduction studies (NCS) to evaluate the nerve and muscle structures in the right upper extremity prior to surgical fusion of the glenohumeral joint for chronic humeral head subluxation and shoulder instability. The patient was diagnosed with a right Erb-Duchenne palsy following a hit-and-run motor vehicle accident in 2001. Physical examination revealed muscle weakness in all muscles representative of the right C5-C6 myotomes and absent biceps brachii and brachioradialis muscle stretch reflexes.

Outcome and Follow Up

The clinical exam findings and electrophysiological testing evidence suggested that the patient had a chronic right C5-C6 radiculopathy affecting the right upper extremity and the right mid cervical paravertebral muscles, consistent with the referring diagnosis of Erb-Duchenne palsy. Needle EMG findings suggested little chance of further neurological recovery, so the patient underwent a right glenohumeral joint fusion to improve the stability of the right shoulder and limit glenohumeral subluxation.

Discussion

This case study highlights the role of a thorough neuromusculoskeletal exam in the differential diagnostic process for a patient with a right C5-C6 Erb-Duchenne palsy, and the role of EMG and NCS in distinguishing brachial plexopathy from cervical radiculopathy. Additionally, EMG and NCS provided prognostic information on potential neurological recovery, suggesting that surgical fusion was the best intervention. JOSPT Cases 2022;2(3):152–158. Epub: 21 June 2022. doi:10.2519/josptcases.2022.11174
Acute Tibial Tuberosity Avulsion Fracture in a Male Adolescent Footballer: A Case Report
Authors: Meredith Alex
Published: June 2024

BACKGROUND: Acute tibial tuberosity avulsion fractures are a rare injury and can occur in sporting adolescent athletes.

CASE PRESENTATION: As the player (a footballer playing in central defense) kicked a ball, they suffered an acute tibial tuberosity avulsion fracture while planting their left leg.

OUTCOME AND FOLLOW-UP: The player underwent open reduction and internal fixation surgery to stabilize the fracture site. A progressive 5-stage rehabilitation program followed. The player returned to competitive games 42 weeks after injury. Given the limited research into rehabilitation approaches following these injuries, the purpose of this case study was to provide an accessible framework of rehabilitation to guide practitioners in the future. A loss of 8° range of motion in knee flexion was observed; however, no other side effects were observed throughout the rehabilitation.

DISCUSSION: Good clinical outcomes have been previously reported for such injuries, which this case study would further support. JOSPT Cases 2023;3(1):1–7. Epub: 4 November 2022. doi:10.2519/josptcases.2022.11421
Implementation of Cognitive Retraining to Diminish Kinesiophobia Associated With Chronic Ankle Instability: A Case Report
Authors: Colgan Kaitlyn , Lopes Alexandre , Nolan David
Published: June 2024

BACKGROUND: In musculoskeletal patients, the incidence of chronic ankle instability is among the highest musculoskeletal impairments in athletes, often accompanied by kinesiophobia and fear-avoidance behaviors. Although the diagnosis of chronic ankle instability is common, there is limited literature available regarding the implementation of cognitive strategies to decrease kinesiophobia throughout rehabilitation.

CASE PRESENTATION: This case describes a 28-year-old female patient who suffered an acute-on-chronic left ankle sprain 1 year before instability symptoms progressed to the point that she sought medical care in the form of a surgical ligamentous repair and arthroscopic debridement. On evaluation, she presented with high levels of kinesiophobia and fear avoidance secondary to the chronic nature of her ankle pain/instability. The use of cognitive retraining strategies and a structured physical therapy program was implemented to improve patient outcomes and allow her to return to recreational sport.

OUTCOMES: The patient was able to demonstrate full return to recreational and work activities without complaints of instability or fear of reinjury. She exceeded meaningful clinically important differences (MCIDs) in all outcomes (Figure 1): Tampa Scale of Kinesiophobia (13-point change; MCID: 6 points), 17 , 25 , 28 Pain and Anxiety Symptom Scale (27-point reduction), 21 , 22 , 27 Foot and Ankle Ability Measure (12-point improvement in ADL subscale; MCID: 8 points), 4 , 20 and 100-point improvement in the Sports subscale, MCID: 9 points). 4 , 20 Literature has found that a score below 22 on the Tampa Scale of Kinesiophobia demonstrates a subclinical level of kinesiophobia, and this patient was able to achieve a score of 21 at discharge, indicative of a significant reduction in fear-avoidance and kinesiophobia tendencies. 28 JOSPT Cases 2023;3(1):16–20. Epub: 6 January 2023. doi:10.2519/josptcases.2023.11339
Hypertrophy of the Subclavius Muscle in Conjunction With Atrophy of the Pectoralis Muscles Postmastectomy: A Cadaveric Case Study
Authors: Jones Beth Moody , Carey Fred J.
Published: June 2024

BACKGROUND: Musculoskeletal impairments of the upper extremity following mastectomy are well documented, although the cause of these impairments is not always known.

CASE PRESENTATION: Asymmetry of the shoulder girdle musculature was found during anterior chest wall dissection of a female cadaver with a history of a left mastectomy at the age of 45 years (age at death: 96 years). The left pectoralis major and minor muscles were markedly smaller than the contralateral pectoralis muscles, whereas the converse was apparent for the subclavius muscles.

OUTCOME AND FOLLOW-UP: In situ measurements of the depth of the bellies of the subclavius muscles demonstrated that the left subclavius depth was nearly twice that of the right on the initial donor. Measurements of the length and wet weight of the muscles confirmed both the increased size and mass of the left subclavius. Further research on an additional 21 pairs of subclavius included 2 additional donors with a mastectomy. When pooled with the original donor's data, the combined 3 subclavius pairs following mastectomy showed a statistical difference in mass (a1 = .05, P = .0354) and width (a1 = .05, P = .0014).

DISCUSSION: The pattern of atrophy of the pectoralis muscles in our primary case suggests that the medial pectoral nerve was damaged during surgery or during postoperative treatment. How this led to the apparent hypertrophy of the left subclavius muscle is unclear. It is possible that because of the atrophy and associated weakness of the left pectoralis muscles, the left subclavius muscle took on a greater role in shoulder girdle stabilization, increasing in size and mass over time. JOSPT Cases 2023;3(2):127–133. Epub: 13 March 2023. doi:10.2519/josptcases.2023.11561
Knee Flexion Range-of-Motion Restriction Following Anterior Cruciate Ligament Reconstruction: A Retrospective Case Report
Authors: Piraino Kathryn
Published: June 2024

BACKGROUND: Anterior cruciate ligament tears are a commonly encountered orthopedic knee injury. Only a few studies focus on interventions to restore knee flexion range of motion. The purpose of this case report is to describe the restoration of motion following anterior cruciate ligament reconstruction.

CASE PRESENTATION: A 26-year-old man with a traumatic knee injury resulting in a right anterior cruciate ligament tear, joint effusion, decreased knee range of motion (ROM), and decreased strength managed conservatively for 3 months.

OUTCOME AND FOLLOW-UP: Restoration of knee flexion ROM was achieved at 16 weeks postoperatively utilizing targeted interventions intended to restore meniscal gliding. The patient maintained knee ROM at 8 months following anterior cruciate ligament reconstruction.

DISCUSSION: When a soft end-feel, posterior knee pain, and reduced flexion ROM are present, tibiofemoral joint mobilizations are a targeted intervention to improve meniscal gliding. The utilization of multimodal interventions assisted in the recovery of functional knee ROM and improved pain. JOSPT Cases 2023;3(3):202-205. Epub: 10 July 2023. doi:10.2519/josptcases.2023.11771
Anti-Phospholipase A2 Receptor Antibody Testing to the Rescue
Authors: Nath A.S. , Herur Siddharth , Taduri Gangadhar , Guditi Swarnalatha , Kalidindi Raja Karthik , Murugan Prasanna , Nair Rahul R. , Ganesh Niranjan
Published: June 2024

Serological testing for M-type anti-phospholipase A2 receptor antibodies (antiPLA2R Ab) has abrogated the need for kidney biopsy to diagnose membranous nephropathy in the appropriate clinical setting. We report a case of a 63-year-old hypertensive male who presented with nephrotic syndrome associated with autosomal dominant polycystic kidney disease which was effectively diagnosed with the use of antiPLA2R Ab test. He achieved complete remission upon treatment with Rituximab. Hitherto, all anecdotal case reports of this uncommon association were diagnosed only by kidney biopsy. We highlight the usefulness of PLA2RAb especially in such cases of difficult-to-biopsy kidneys.
A Case of Acute Renal Infarct Secondary to Protein S Deficiency
Authors: Mathews Daniel Sam , George Ninoo , Jeyasekharan Ranjit
Published: June 2024

Renal infarction is an underdiagnosed and underreported condition with multiple etiologies. A 45-year-old man presented with acute pain in the right lumbar region, CT scan showed a wedge shaped, non-enhancing, hypodense lesion in the cortex of the upper pole of the right kidney- suggestive of infarct. A pro-thrombotic workup revealed a protein S deficiency and a heterozygous mutation for MTHFR gene. Protein S is a vitamin-K dependent plasma glycoprotein, the deficiency of which is associated with a hypercoagulable state, which in turn led to renal infarction in this patient.
MAIN OUTCOMES OF VIRAL HEPATITIS B-RELATED ONCOGENICITY STUDY OVER THE PAST THIRTY YEARS
Authors:   National center of oncology, Baku, Azerbaijan, Mamedov M. K. , Mikhailov M. I. ,   FBIS Central Research Institute of Epidemiology of Rospotrebnadzor, Russian Federation
Published: June 2024

The review is devoted to viral hepatitis B-related oncological aspects and reflects the most important outcomes of this infection 30-year study in oncological terms. The authors summarized the data demonstrating the existence of several hepatitis B virus (HBV)-related oncological aspects, in particular: the role of HBV infection in the occurrence of hepatocellular cancer and tumors of other histogenesis; HBV spread and course peculiarities in cancer patients; the significance of this infection in oncology practice; treatment tactics for cancer patients with HBV infection; drug therapy potentials for the management of the infection negative impact on the course of cancer.
Analysis of the features of the synthesis of object management systems with a delay using the dynamic compensation method
Authors: Валерий Ф.Л. , Никита О.Л.
Published: June 2024

Рассмотрены недостатки и преимущества применения одного из методов современной теории управления – метода динамической компенсации для синтеза систем управления с запаздыванием. Цель исследования – анализ влияния факторов, снижающих качество работы системы управления, синтезируемой на основе применения принципа динамической компенсации. Объект исследования характеризуется наличием неизменяемого запаздывания и отсутствием полной информации о состоянии системы. Обоснована целесообразность применения обратных моделей для объектов с любой инерционностью для улучшения качества интегральной оценки и динамической ошибки системы управления, что подтверждено результатамивычислений и проведенных исследований. Отмечено, что получение производных при использованиитолько выходной переменной объекта для реализации обратной модели в системе с обратной связью по выходу на практике затруднено. С учетом этого рекомендуется использование вместо производных от выходной переменной объекта оценок переменных состояния, получаемых с использованием наблюдателей состояний.

The disadvantages and advantages of using one of the methods of modern control theory – themethod of dynamic compensation for the synthesis of control systems with a delay are considered. The purpose ofthe study is to analyze the influence of factors that reduce the quality of the control system, synthesized on the basis of the application of the principle of dynamic compensation. The object of the study is characterized by the presence of an immeasurable delay and the lack of complete information about the state of the system. The expediency of using inverse models for objects with any inertia to improve the quality of integral estimation and dynamic error of thecontrol system is substantiated, which is confirmed by the results of calculations and conducted research. It is noted that obtaining derivatives when using only the output variable of an object to implement an inverse model in asystem with output feedback is difficult in practice. With this in mind, it is recommended to use estimates of state variables obtained using state observers instead of those derived from the output variable of the object.
Ergatic systems: basic modeling principles
Authors: Александр М.Д. , Ирина А.Г. , Пырков Дмитрий Дмитриевич
Published: June 2024

В приложении к разработке тренажных и обучающих комплексов дается формализованная оценка управляющих воздействий оператора в зависимости от технических параметров объекта управления. Предполагается, что оценка оператором объекта в процессе нормальной эксплуатации производится исходя из собственных частот колебаний и коэффициентов демпфирования. Исходя из различных представлений управляющих воздействий разрабатываются параметры и функционалы качества для оценки имитационных характеристик комплексов для подготовки операторов. Для ряда эргатических систем разработаны модели управляющих воздействий и осуществлена оценка влияния параметров объекта на характеристики управления. Исходя из заданных имитационных характеристик обучающих комплексов для подготовки операторов эргатических систем дается оценка параметров интегрирования уравнений движения в имитаторе динамики объекта управления (использовались при разработке имитаторов динамики для транспортных систем).

In the annex to the development of training and educational complexes, a formalized assessment of the operator’s control actions is given depending on the technical parameters of the control object. It is assumed that the operator's assessment of the object during normal operation is based on the natural frequencies of vibrations and damping coefficients. Based on various representations of control actions, quality parameters and functionals are developed to evaluate the simulation characteristics of operator training complexes. For a number of ergatic systems, models of control actions have been developed and the influence of object parameters on control characteristics has been assessed. Based on the given simulation characteristics of training complexes for training operators of ergatic systems, an assessment is made of the parameters for integrating the equations of motion in the simulator of the dynamics of the control object (used in the development of dynamics simulators for transport systems).
Investigation of the effectiveness of encryption methods in the system of automatic dependent surveillance-broadcasting
Authors: Антонов А.А. , Повалишина М.А.
Published: June 2024

Защита конфиденциальности и целостности данных является важным аспектом в АЗН-В системах, поскольку они обрабатывают и анализируют большие объемы информации для принятия соответствующих мер по обеспечению безопасности. Данная технология позволяет летному составу и авиадиспетчерам на наземном пункте наблюдать движение воздушных судов (полёт) с большей точностью, чем это было доступно ранее, и получать аэронавигационную информацию. АЗН-В также передает летному составу в реальном времени погодную информацию. Эта информация значительно расширяет осведомлённость лётчика об обстановке и повышает безопасность полётов. Доступ к АЗН-В информации свободен и бесплатен для всех. В статье рассмотрены различные алгоритмы и протоколы шифрования, включая симметричное и асимметричное шифрование, а также методы на основе эллиптических кривых. Основной целью является обеспечение безопасности передачи и хранения данных в АЗН-В системах, с учетом требований по производительности и эффективности.

Protecting the confidentiality and integrity of data is an important aspect in ADS systems, as they process and analyze large amounts of information to take appropriate security measures. This technology allows flight personnel and air traffic controllers at a ground station to observe the movement of aircraft (flight) with greater accuracy than was previously available, and receive aeronautical information. The AZN-V also transmits real-time weather information to the flight crew. This information significantly increases the pilot's awareness of the situation and increases flight safety. Access to the information is free and free for everyone. The article discusses various encryption algorithms and protocols, including symmetric and asymmetric encryption, as well as elliptic curve-based methods. The main goal is to ensure the security of data transmission and storage in the ADS-In systems, taking into account the requirements for performance and efficiency.
The impact of transport infrastructure facilities on the safety of underage road users
Authors: София Л.Н. , Ирина Н.К. , Тимур Р.Х.
Published: June 2024

В данной статье авторы рассматривают вопросы влияния объектов транспортной инфраструктуры на безопасность несовершеннолетних участников дорожного движения на примере мкр. Новознаменский г. Краснодара.

In this article, the authors consider the impact of transport infrastructure facilities on the safety of underage road users using the example of the MKR. Novoznamenskiycity of Krasnodar.
On the issue of structuring information for storing laser scanning data
Authors: Роман А.Д. , Дмитрий А.Г. , Сергей В.С. , Дарья А.Б. , Константин Е.Т.
Published: June 2024

Лазерное сканирование является перспективным методом получения информации об объектах и местности. Один из наиболее трудоемких этапов работы с данными лазерного сканирования – обработка полученных данных. В статье рассмотрены наиболее распространенные методы предварительной обработки облаков точек. Приведен сравнительный анализ методов структуризации данных трехмерного лазерного сканирования. Определен наиболее эффективный, а именно октодерево. Ключевые слова: облако точек, пространственная информация, предобработка данных, методы структуризации данных, k-мерное информационное пространство

Laser scanning is a promising method of obtaining information about objects and terrain. One of the most time – consuming stages of working with laser scanning data is processing the received data. The article discusses the most common methods of preprocessing point clouds. A comparative analysis of methods for structuring three-dimensional laser scanning data is presented. The most efficient one has been determined, namely the octree.
Development of a software and hardware complex for measuring the parameters of the driver’s psychophysiology in the process of driving a moving car
Authors: Сергей С.Б. , Судки О. , Анатолий А.С.
Published: June 2024

Изучение влияния дорожных условий на психоэмоциональное состояние водителя должно являться основой для разработки рекомендаций по повышению безопасности дорожного движения. В статье рассмотрен вопрос, связанный с разработкой программно-аппаратного комплекса для измерения параметров психофизиологии водителя в процессе управления движущимся автомобилем. Проанализированы основные подходы к оценке психофизиологического состояния водителя и предложена усовершенствованная аппаратура для оценки показателей таких состояний.

The study of the influence of road conditions on the psychoemotional state of the driver should be the basis for the development of recommendations to improve road safety. The article considers the issue related to the development of a software and hardware complex for measuring the parameters of the driver’s psychophysiology in the process of driving a moving car. The main approaches to assessing the psychophysiological condition of the driver are considered and improved equipment for evaluating indicators of such conditions is proposed.
An atomic radii set and Generalized Born implicit solvation model trained using explicit water solvation free energy data
Authors: Wang Yuzhang , Tian Chuan , Pincay Jorge , Simmerling Carlos
Published: June 2024

Compared with the other common implicit and explicit water models, Generalized Born (GB) models can provide a fast approximation of solvation free energy that is reasonably accurate but fast enough to use in molecular dynamics (MD) simulations. This enhances conformational sampling of the solute molecules, and also can be a valuable component of multi-scale simulations. We previously developed the GB-Neck2 model, which exhibited improved secondary structure balance and was used to successfully fold a series of small proteins. More recent simulations using GB-Neck2 with updated protein models suggest that α-helices remain somewhat over-stabilized. Here, we develop a more self-consistent model, retraining both the intrinsic solvation radii as well as the GB model parameters, using the solvation free energies of an explicit water model as training references. The new radii set, named MIRO, when used with the GBNSR6 implicit solvent model leads to improved reproduction of solvation free energies calculated in explicit water. The new GB-Neck3 model shows a good balance of secondary structures: the stability of β-sheets is improved, while the previously over-stabilized α-helices became less favorable, as expected. GB-Neck3 and MIRO radii should extend the range of problems accessible to biomolecular simulation.
Hypershifted Spin Spectroscopy with Dynamic Nuclear Polarization at 1.4 K
Authors: Pang Zhenfeng , Sheberstov Kirill , Rodin Bogdan A. , Lumsden Jake , Banerjee Utsab , Abergel Daniel , Bodenhausen Geoffrey , Tan Kong Ooi
Published: June 2024

Dynamic nuclear polarization (DNP) is a nuclear magnetic resonance (NMR) hyperpolarization technique that mediates polarization transfer from unpaired electrons to nearby nuclear spins, which then relay the polarization to more remote nuclear spins in the bulk via spin diffusion. Despite widespread applications of DNP, the role of these nearby nuclear spins has never been properly characterized because they were hitherto believed to be unobservable or ‘hidden’ due to severe shifts or line broadening due to strong electron-nuclear couplings, i.e., their NMR resonances are ‘hypershifted’ beyond detection limit. By using DNP on a frozen glycerol-water mixture (‘DNP juice’) doped with TEMPOL at 1.4 K, we employed a newly introduced technique known as SPIn Diffusion Enhanced Saturation Transfer (SPIDEST), to indirectly reveals the spectrum of these hypershifted spins. Then, we performed direct two-pulse echo experiment, and we report here the results of the first direct observation of these hypershifted 1H nuclear spins under actual DNP conditions. The inhomogeneously broadened 1H NMR lines span a range of 10 MHz and can be directly observed by acquiring a series of frequency-stepped NMR spectra. Experiments repeated with deuterated TEMPOL proves that the hypershifted 1H signals indeed originate from methyl and methylene protons that are covalently attached to TEMPOL. In addition to characterizing the relaxation times (T1 and T2) of these nearby nuclei, we show that their polarization can be transferred to the bulk via spin diffusion using 2D NMR, i.e., the transport is not impeded by a spin diffusion barrier, as has been widely believed so far. This work presents a new form of spectroscopy that directly characterizes the nearby nuclei that we like to refer to as “hypershifted” nuclei. This could lead to the design of more efficient DNP polarizing agents and to a better understanding of the role of the molecular structures of paramagnetic agents.
Functional state of the liver and endothelium in patients with menopausal metabolic syndrome
Authors: Bulatova Irina A. , Shevlyukova Tatyana P. , Gulyaeva Inna L. , Sobol Alexander A. , Khasanova Valentina V.
Published: June 2024

Aim. To assess the functional state of the liver and endothelium in patients with menopausal metabolic syndrome, depending on the degree of obesity.
Materials and methods. 70 patients with menopausal metabolic syndrome and obesity of varying degrees with an average age of 49.9±1.1 years and 30 practically healthy women without obesity and liver pathology with an average age of 47.3±2.6 years (comparison group) who were in the early postmenopausal period were examined. All women underwent biometric and laboratory-instrumental examination, including assessment of biometric indicators, determination of estradiol levels in the blood, biochemical markers of cytolysis and cholestasis, markers of endothelial dysfunction, assessment of microvascular tone reaction with calculation of the thermal vasodilation index, ultrasound examination of the liver and calculation of the Hepatic steatosis index (HSI).
Results. All patients with menopausal metabolic syndrome had a genoid type of obesity and hypoestrogenism. The level of estradiol decreased more significantly during the transition to the 1st degree of obesity (p=0.001). According to ultrasound and the HSI index, signs of liver steatosis were found in all patients with menopausal metabolic syndrome. Functional liver tests were within the reference values, 13% had an increase in the level of alkaline phosphatase, more significant in the group with grade 3 obesity (p=0.034). Laboratory markers of endothelial dysfunction were significantly higher in patients with menopausal metabolic syndrome than in the comparison group. The muscular and neurogenic index of thermal vasodilation significantly decreased in women with grade 1 obesity compared to the group with “pre-obesity“ (p=0.041 and 0.047). The lowest endothelial response was observed at the transition to the 1st degree of obesity in comparison with women with excess body weight.
Conclusion. For patients with menopausal metabolic syndrome to assess the condition of the liver, it is recommended to conduct a comprehensive instrumental laboratory examination, including ultrasound examination of the liver, biochemical parameters and calculation of the steatosis index.
Chronic endometritis. Local prooxidant, antioxidant and immunometabolic disorders. An open-label, prospective, randomized study
Authors: Gizinger Oksana A. , Sorokin Yury A. , Radzinskiy Viktor E.
Published: June 2024

Aim. To determine local features of lipoperoxidation processes, antioxidant defense, state of matrix metalloproteinases in chronic endometritis.
Materials and methods. Eighty women aged 29.33±6.71 (min-max [24–36]) with histologically and immunohistochemically confirmed chronic endometritis and a history of reproductive losses were examined (group 1). The control group consisted of 30 patients without chronic endometritis confirmed by the results of a histochemical study and no history of reproductive losses, suffering from infertility of tubal-peritoneal origin at the age of 30.11±6.9 years (min-max [24–37]; group 2). All 130 patients underwent transvaginal echography of the pelvic organs, and histological and immunohistochemical examination of endometrial samples was performed. The activity of lipid peroxidation factors was analyzed: primary, secondary and final products of lipid peroxidation in heptane and isopropanolol fractions of uterine cavity aspirate, enzymes of the antioxidant system: superoxide dismutase, catalase, glutathione peroxidase, deoxyribonuclease I (DNase), by spectrophotometric method, remodeling factors – matrix metalloproteinases MMP-2, -9 by flow fluorimetry.
Results. In patients of group 1, according to transvaginal echography of the pelvic organs, M-echo was 6.29±1.22 mm, in group 2 – 9.10±1.15 mm. In chronic endometritis, disruption of pro-oxidant and activity of antioxidant factors in the endometrium in women with chronic endometritis and a history of reproductive losses. In the heptane fraction of the phenolic extract, the concentration of primary products of lipid peroxidation (diene conjugates) was 12.98% higher than in the control, the content of secondary products of lipid peroxidation (ketodienes) was higher by 15.45%, conjugated trienes by 18.67% higher than the values in the control group, which indicates increased lipid peroxidation of endometrial cell membranes during CE. In the isopropanol phase, the products of lipid peroxidation of phospholipid acyl residues are detected. In the isopropanol fraction of the lipid extract, the amount of diene conjugates was higher, ketodienes by 24.32% and conjugated trienes by 26.14%. An increase in the activity of the enzymes superoxide dismutase by 23.98%, catalase by 14.34%, glutathione peroxidase by 12.39%, and DNase by 2.9 times was recorded compared to the indicators of group 2.
Conclusion. Chronic endometritis is accompanied by changes in the system of pro-oxidant and antioxidant factors, the content of tissue remodeling products. The pathogenetic changes underlying oxidative stress in the endometrium may be increased leukocyte infiltration, imbalance of primary, secondary and end products of lipid peroxidation, enzymes superoxide dismutase, catalase, glutathione peroxidase, deoxyribonuclease I (DNase), expression of matrix metalloproteinases-2, -9.
The nucleolar phase of signal recognition particle assembly
Authors: Issa Amani , Schlotter Florence , Flayac Justine , Chen Jing , Wacheul Ludivine , Philippe Manon , Sardini Lucas , Mostefa Lalia , Vandermoere Franck , Bertrand Edouard , Verheggen Céline , Lafontaine Denis LJ , Massenet Séverine
Published: June 2024

The signal recognition particle is essential for targeting transmembrane and secreted proteins to the endoplasmic reticulum. Remarkably, because they work together in the cytoplasm, the SRP and ribosomes are assembled in the same biomolecular condensate: the nucleolus. How important is the nucleolus for SRP assembly is not known. Using quantitative proteomics, we have investigated the interactomes of SRP components. We reveal that SRP proteins are associated with scores of nucleolar proteins important for ribosome biogenesis and nucleolar structure. Having monitored the subcellular distribution of SRP proteins upon controlled nucleolar disruption, we conclude that an intact organelle is required for their proper localization. Lastly, we have detected two SRP proteins in Cajal bodies, which indicates that previously undocumented steps of SRP assembly may occur in these bodies. This work highlights the importance of a structurally and functionally intact nucleolus for efficient SRP production and suggests that the biogenesis of SRP and ribosomes may be coordinated in the nucleolus by common assembly factors.
“A minha vida vale menos que uma pelota de minério"
Authors: Silva Simone Maria da
Published: June 2024

A gente não pode deixar ninguém contar a nossa história. Porque, se as pessoas forem contar a nossa história, elas não vão contar o que aconteceu. Ela não vai ter aquele sentimento de colocar aquilo que aconteceu com a gente. Somente eu posso falar das minhas feridas invisíveis. Então, eu aprendi. Hoje eu não vou contar uma história. Hoje eu sou a história. Eu virei a história. E não posso deixar ninguém segurar a caneta da minha história na mão. A minha história sou eu que devo escrever. 
[Este documento foi produzido entre os meses de maio e julho de 2021 a partir de conversações sobre a luta das populações atingidas em Barra Longa realizadas entre Simone Maria Silva, atingida pelo rompimento da barragem de Fundão em Barra Longa/MG e militante do Movimento dos Atingidos por Barragens, e Guilherme Cavicchioli Uchimura, membro da equipe editorial da revista InSURgência responsável pela transcrição mediada da voz de Simone, bem como pela edição e pela finalização gráfica do texto.]
A esterilização compulsória em mulheres vulneráveis como “medida de segurança pública": reflexões sobre o controle do corpo, gênero e sexualidade
Authors: Marques Juliana Maria Duarte , Cardoso Ana Lúcia Borges Coelho , Neves André Luiz Machado das
Published: June 2024

O presente artigo tem por objetivo compreender de que forma as relações de poder sobre o corpo feminino se instrumentalizam na prática da esterilização compulsória de mulheres vulneráveis, como política de Segurança Pública. Para tanto, por meio de uma pesquisa bibliográfica, investigaram-se o corpo e a sexualidade, na perspectiva histórica sobre o gênero; e analisar os julgamentos da ação “I.V Vs Bolívia”, proferido pela Corte Interamericana de Direitos Humanos, e da Ação Civil Pública, proposta na cidade de Mococa-SP, sob a jurisdição do Tribunal de Justiça de São Paulo. Por fim, concluiu-se que os direitos sexuais e reprodutivos estão constantemente ameaçados ou violados, por quem detém o poder, utilizando-se como argumento a proteção da família e a manutenção da moral e da ordem. Por consequência, os debates deixam de ser considerados da saúde coletiva e são alocados como casos de polícia, o que promove o encarceramento e a perda da autonomia sobre os corpos de mulheres, principalmente aquelas que estão em situação de vulnerabilidade.
Registro da Carta do Bacharel Paulo Reglus Neves Freire
Authors: Univesidade do Recife Secretaria da Faculdade de Direito da
Published: June 2024

Trata-se do documento histórico do registro da Carta do Bacharel em Direito de Paulo Freire pela Faculdade de Direito da Universidade de Recife em 10 de setembro de 1949.
Documentos que comprovam monitoramento de Paulo Freire no exterior durante seu exílio
Authors: Ministério das Relações Exteriores
Published: June 2024

Trata-se de diversos documentos históricos que evidenciam o monitoramento de Paulo Freire no exterior durante seu exílio no período da ditadura militar brasileira.
A luta dos movimentos sociais pela saúde
Authors: Machado Daiane
Published: June 2024

A organização do livro “Saúde, Direito e Movimentos Sociais”, feita por Elda Coelho de Azevedo Bussinguer, André Filipe Pereira Reid dos Santos e Ricardo Prestes Pazello, se desafia, neste contexto complexo de pandemia em decorrência da COVID-19, a lançar uma publicação que traz discussões aprofundadas acerca do direito à saúde. Os textos, frutos de reflexões coletivas ocorridas em espaços como os do Instituto de Pesquisa, Direitos e Movimentos Sociais (IPDMS) e do Programa de Pós-Graduação em Direitos e Garantias Fundamentais da Faculdade de Direito de Vitória (FDV), relacionam a luta pelo direito à saúde e sua relação histórica com a democracia e as organizações populares.
Sobre reaprender o significado do trabalho de base, reinventá-lo diante das atuais configurações da realidade e poder “arrancar alegria ao futuro”
Authors: Ferreira Ayala Lindabeth Dias , Benitez Martins Carla , Ribas Luiz Otávio
Published: June 2024

Entrevista com Ayala Lindabeth Dias Ferreira, realizada por Carla Benitez Martins e Luiz Otávio Ribas.
Count Muravyov-Amursky and Transbaikalia
Authors:   S. I. Vavilov Institute of History of Natural Science and Technology RAS, Postnikov A. V. , Konstantinov M. V. ,   Professor Trans-Baikal State University, Konstantinova T. A. ,   State Archives of Zabaikalsky Krai
Published: June 2024

Governor-General of Eastern Siberia N. N. Muravyov proposed to focus on solving continental problems, leaving Alaska to America. He developed a plan for the development of the Amur, choosing Transbaikalia as a springboard for solving socio-political and economic problems, where the Trans-Baikal Region was created with the center in Chita with the statute of the city, the TransBaikal Cossack army, the registration of peasants to factories was canceled. Chita began to play the role of the Eastern Kronstadt and the upper Amur pier. Since 1854, Amur expeditionary raftings began with the Ingoda or the Shilka, ensuring the movement of military personnel, mainly from trans-Baikal Cossacks, weapons and food to the mouth of the Amur. During the first four years of rafting, Muravyov mastered and began to populate the Amur banks with migrant peasants. He managed to repel the attack of the Anglo-French squadron and convince the Chinese authorities of Russia's peaceful and friendly intentions. Friendly agreements were concluded with China – the Aigun, Tianjin and Beijing agreements on the delimitation of the territory along the Amur and Ussuri. For mastering the Amur River, according to the rescript, Muravyov was granted by Alexander II the title of count and the honorary name Amur. In modern scientific and educational literature, there is a clear underestimation of the activities of Count N. N. Muravyov-Amursky.
Movement to the East: Amur Alloys by N. N. Muravyov (1854–1857)
Authors:   Irkutsk State University, Kuznetsov S. I. ,   Hokkaido University, Mishchenkova M. S. ,   Irkutsk State University
Published: June 2024

The article analyzes the reasons, course and main results of the Amur unions of Nikolai Nikolaevich Muravyov, organized by him with the aim of joining the Russian Empire and leaving the banks of the Amur in the middle of the 19th century. Particular attention is paid to foreign policy conditions, in the opening of navigation along the Amur and the annexation of the Amur region became the most important party for ensuring the security of the Far Eastern rulers of the Russian Empire, taking into account the strengthening of European power in the Pacific Ocean and the course of the Crimean War. The most important results achieved by N. N. Muravyov based on the results of three alloys organized in 1854, 1855 and 1857 are noted.
The Largest Penal Servitude of the Russian Empire at the Beginning of the 20th Century
Authors:   Irkutsk State University, Ivanov А. A.
Published: June 2024

The article is devoted to the history of the participation of criminal convicts in the construction of the Amur Railway in 1910–1916. The author establishes the total number of “involuntary” builders, the types of work they were engaged in, the amount of wages, and also describes the features of working and living conditions. Much space in the article is devoted to the prisoners of the Aleksandrovsk Central Convict Prison, who participated in the years 1910–1913, along with the convicts of the Nerchinsk mountain district, in the construction of the western branch of the Amur Railway.
Atresia anal: reporte de un caso
Authors: Huerta Gil Andres Jesus , Rivera Morales Emily Nicole
Published: June 2024

Se describe el caso de una paciente con atresia anal.  El ano imperforado o atresia anal es una malformación anorrectal congénita en la que no existe una abertura anal normal al nacer. Aproximadamente la mitad de los pacientes con atresia anal también tienen anomalías de otros sistemas de órganos. El diagnóstico tardío puede ocurrir en uno de cada cinco recién nacidos, a pesar de la evaluación posparto de rutina. Tal retraso puede aumentar la morbilidad y la mortalidad. Se reporta el caso de una fémina de 2 meses y 15 días de edad, quien acudió en compañía de su madre a primer control de niño sano en un centro de salud tipo A en una parroquia rural. En esta paciente es importante destacar que no había recibido ningún control médico hasta que llego a nuestro centro de salud a los 2 meses y 25 días de nacida. Durante la exploración física se evidencio la ausencia de ano y la evacuación de heces a través de la vagina (cloaca) si bien es cierto que el diagnóstico tardío puede ocurrir en uno de cada cinco recién nacidos, en esta paciente el retraso fue de más de 2 meses lo cual no pudimos encontrar casos similares en la literatura.
Fertility and Some Growth Characteristics of Lambs in Akkaraman Sheep Grown in Çorum Province
Authors: Tüfekci Hacer , Tozlu Çelik Hilal , Özten Başak
Published: June 2024

Objective: The aim of this study was to determine the reproductive efficiency and lamb growth characteristics of Akkaraman sheep in Çorum province under breeder conditions.

Material and Methods: The animal material of the study consisted of 2214 Akkaraman sheep and 2508 Akkaraman lambs from three different farms located in the center of Çorum province. The study was conducted between 2019 and 2022. In the study, reproductive characteristics of Akkaraman sheep and birth, weaning live weights, and survival of lambs were determined.

Results: The mean birth weight of lambs was 4.15 kg, and the mean weaning weight (75th day) was 19.58 kg. Birth and weaning weights differed according to year, farm, type of birth, and sex (P
Population and Characterization of Rhyzospheric Bacteria of Pineapple Plant (Ananas comosus L. Merr) on The Highland Land of Lumban Sihite Village, Regency Dairi
Authors: Ginting Monika , Manalu Kartika , Nasution Rizki Amelia
Published: June 2024

The rhizosphere is the part of the soil around the roots of plants which is known to have a greater number of rhizosphere bacteria compared to the soil far from the roots. This research aims to determine the population and characteristics of rhizosphere bacteria from pineapple plants (Ananas comosus L. Merr) on the highland land of Lumban Sihite village, Dairi district. The stages used in this research were taking samples at three different points, then carrying out multilevel dilutions, inoculating them into petri dishes filled with PCA (Plate Count Agar) media, then counting the growing colonies using the TPC (total plate count) method, purification, morphological characterization, gram staining and biochemical tests. The research results obtained at point 3 had the largest population of 463.96 x 10⁴ CFU/g, while point 1 had the lowest population, namely 20.07 x 10⁴ CFU/g. Based on the results of morphological, gram staining and biochemical characterization of bacterial isolates, the isolates were identified as belonging to the genus Azospirillum, Bacillus, Pseudomonas and Azotobacter.
Case of Erythroderma Skin Disorder Caused by Drug Eruption
Authors: Idris Irma Suryani , Purnamasari A. Bida , Suryani A. Irma
Published: June 2024

Erythrodema or also called exfoliative dermatitis is an inflammatory skin disease with erythema and fine scales that affect almost the entire surface of the skin. Histopathological examination will vary and sometimes be non-specific, depending on the triggering disease. Generally there is hyperkeratosis with focal parakeratosis, mild acanthosis and chronic inflammatory cell infiltration. The author would like to report a case of erythroderma in a 62 year old woman who was hospitalized for 8 days. The diagnosis is made based on the history, clinical picture and histopathological examination. The results of the case report found that skin tissue preparations showed that the epidermis had regenerated. The superficial dermis appears as mild perivascular lymphocytic accompanied by 1-2 eosinophils.
OS PESCADORES ARTESANAIS E A PREVIDÊNCIA SOCIAL NO MUNICÍPIO DE NOVO AIRÃO-AM.
Authors: Filha Maria Ferreira de Oliveira , Scherer Elenise Faria , Diógenes Antônia Mara Raposo
Published: June 2024

O artigo tem por objetivo analisar as condições de acesso dos pescadores artesanais à Previdência Social no município de Novo Airão-AM. Os pescadores artesanais foram inseridos na Previdência Social como segurados especiais a partir da Constituição Federal de 1988 e passaram a acessar os seguintes direitos: aposentadoria por idade, por invalidez, auxílio-doença, salário maternidade, auxílio-acidente, pensão por morte e auxílio-reclusão. Trata-se de uma pesquisa qualitativa que se utilizou de fonte bibliográfica, documental, entrevistas, observação direta e registro fotográfico. Com a realização da pesquisa verificou-se que os pescadores enfrentam inúmeras dificuldades para acessar tais direitos devido: à ausência de agências do INSS no município, à falta de documentação pessoal e profissional e à falta de informação sobre os direitos a que faz jus como segurado especial.
O CORPO ESCULPIDO: ENTRE OS MITOS E RITOS DO POVO TICUNA NA AMAZÔNIA
Authors: Santos Ana Lucia Cavalcante dos , Bourguignon Priscila R. de A. , Soares Artemis
Published: June 2024

Este texto é resultado da reflexão sobre a sexualidade presente nas interpretações da cosmovisão, o mito e ritual do povo Ticuna. O estudo teve por objetivo compreender o mito e rito do povo Ticuna à luz das interpretações da literatura dos seguintes autores: Nimuendaju (1952), Soares(1999)e MatarezioFilho(2015),visando a maneira que o povo desta etnia constrói, compreende e se posta para o mundo através da sexualidade presente no contexto do ritual da moça nova. Entrelaçaremos transversalmente com as pesquisas da categoria Corpo de Le Breton (2010) no conceito de corpo social. Justificamos tal reflexão devido a forma como os Ticunas tratam suas relações e pelos ensinamentos vivenciados entre eles, através da sexualidade presente nos mitos e ritos que estruturam suas instituições sociais.Num dialogar com as interpretações das referências dos autores citados buscamos também, a compreensão da sexualidade presente nos objetos como “osbonecosde madeira”que tem por representação do corpo (índio) do homem e mulher (índia) com suas genitálias talhados em madeira que foram observados durante visita ao museu Povos da Amazônia.A estratégia metodológica se firma na pesquisa bibliográfica, fonte material e iconográfica (fotografia) do objeto, captada em visita ao museu. Discorremos a análise das interpretações por pesquisa e leitura de artigos relacionados com o tema que contribuíram para a conclusão desta reflexão e de forma qualitativa para apresentação dos resultados. Como conclusão vislumbramos o respeito às diferenças e a compreensão equitativa da sexualidade através da interculturalidade, numa cúmplice e respeitosa aceitação da sexualidade do outroque nos aponta a educação sexual do povo Tikuna