bluuebunny/crossref_metadata_2025 huggingface dataset:
Infections in type 2 diabetic patients and its correlations with glycosylated haemoglobin in a tertiary care teaching hospital
Authors: Mohapatra Namita , Soreng Pratima , Mohanty Dibya Prasanna , Mohapatra Gurukrushna
Published: November 2019

Background: Diabetes mellitus increases the risk of infections and results in adverse outcomes, but the effect of better glycaemic control has not been thoroughly investigated. Therefore, it was intended to study the various types of infections in Type 2 diabetic patients and its correlation with HbA1c.Methods: It was a prospective observational study for one year, conducted on Type 2 diabetic patients hospitalized for various causes. Patients with HIV infection or immunocompromised state were excluded. Routine investigations, radiological and culture studies were conducted as required to identify the various infections present. The prevalence of infections was then corelated with blood glucose and HbA1c levels.Results: Total 105 hospitalized diabetic cases were studied, out of which infections were detected in 72 (68.6%) patients, which was found to be statistically significant. The most common infection detected was UTI (45.8%). Among the UTI patients, E. coli was the most common organism isolated (52.3%) followed by Enterococcus (19%), Pseudomonas (19%) and Citrobacter (9.5%). Infections occurred in 61 (82.4%) patients with HbA1C >6.5% and in 11 (35.5%) patients with HbA1C <6.5%, which was found to be statistically significant.Conclusions: Diabetes increases the risk of infections. Urinary tract infection is the most common infection, affecting the females predominantly. An association between current hyperglycaemia, glycosylated haemoglobin  and infection risk in type 2 diabetes patients was found.
Serum lipid profile as predictor of clinical outcome in pediatric patients with dengue infection at a tertiary care hospital
Authors: Siddiqui Mohd. Saeed S. , Loya Amruta Kailash , Kanumala Udaykumar , Kakade Jagannath R.
Published: November 2019

Background: Dengue is a serious mosquito-borne viral disease which in recent years has become a major international public health concern. Early detection of individuals at risk of developing severe forms of dengue could be possible with the identification of an ideal biomarker, which has been the focus of several research studies. Changes in lipoprotein profile during infection probably are primarily cytokine induced Interactions between microorganisms and lipoproteins occur in viral infections. There have been very few studies that address and elucidate a correlation between dengue fever severity and changes in the lipid profile.Methods: This study was conducted in paediatric patients with dengue infection of age group between 1 to 18 years MGM Medical College and Tertiary Care Hospital of Aurangabad City.Results: There was statistically significant association between TG (mg/dl) level and dengue disease category (DF vs DHS+DSS) among the patients. Overall the combine lipids were significantly predicting dengue disease category (DF, DHS and DSS). Serum lipids (triglycerides, LDL and cholesterol) among the patients significantly predict dengue disease category (DF, DHS and DSS). There was negative correlation between triglycerides level and HDL and hospital Stay which was found to be statistically significant.Conclusions: Reduced serum lipid profile can be used as a cost-effective laboratory investigation prompting a high suspicion of severe dengue infection especially in resource poor setting where serological tests may not be available.
Implementation of Specific Time Work Agreements at PT Bank Mandiri (Persero) Tbk. As a State-Owned Enterprise
Authors: Rauf Rohandy Harly , Yuslim Yuslim , Khairani Khairani
Published: November 2019

The Basic Law of the Republic of Indonesia 1945 has guaranteed the right to get a job for every citizen. As an elaboration of Article 28D paragraph (2) of the Constitution, the State issues Law Number 13 of 2003 concerning Manpower which regulates all matters concerning employment relations and rights and obligations between workers / laborers and employers / companies. The Manpower Law regulates PKWT in chapter IX concerning Employment Relations starting from Article 56 paragraph (2) to Article 59. Currently the contract system or PKWT is widely applied by companies / employers in carrying out work relationships. While the type of work done by workers with PKWT is not in accordance with what is mandated by the Manpower Act. This is a denial of Article 59 of the Manpower Act even carried out by SOEs, one of which is Bank Mandiri, which employs workers with PKWT to do work that should be done with PKWTT.
Evaluation of biomechanical risk factor and relationship with disability of upper limbs in assembly workers of porcelain manufacturing company
Authors: Fadaei F , Ordudari Z
Published: November 2019

Introduction: Upper limbs are more susceptible to musculoskeletal disorders. The OCRA method is suggested to measure the biomechanical risk of the associated with the manual, repetitive work in upper limbs. Questionnaires can be used to measure the symptoms of diseases and disabilities. The DASH questionnaire is one of these questionnaires that are used to evaluate disability of upper limbs. In this study attempted to evaluate the biomechanical risk factor and relationship with disability of the upper limbs in assembly workers.
Method: The study was a descriptive – analytic and cross-sectional one being and was carried out among 120 female assembly workers. For the measurement of biomechanical risk factor and disability of the upper limbs, the OCRA method and Iranian version of DASH have been used, respectively. Data analysis was carried out using SPSS 20. It is noteworthy to mention that P value <0.05 was considered significant.
Results: In this study, assembly workers were in terms of risk factors of biomechanics and upper limb disability in low risk and low disability, respectively. In addition, the relationship between biomechanical risk factor and disability of upper limbs was significant and direct (P value <0.05).
Conclusion: Since the relationship between biomechanical risk factor and disability of upper limbs, was significant and direct, it can be concluded that musculoskeletal disorders due to inappropriate working conditions can lead to motor limitation and upper limb disability at different levels.
Determine the average score of skin exposure to chemotherapy drugs in oncology staffs at hospitals and health services of Shahid Sadoughi university of medical Sciences and health Services by DREAM method in 2015
Authors: Mansouri Y , Dehghani A , Barkhordari A , Zare sakhvidi M
Published: November 2019

Introduction: Occupational dermal exposure to antineoplastic drugs is the one of the most important routes among healthcare staff. Several antineoplastic drugs have been classified as carcinogens by the International Agency for Research on Cancer (IARC). This study investigated dermal exposure of oncology divisions staff to the anticancer drugs (ANDs) in hospitals of Shahid Sadoughi University of Medical Sciences.
Method: In this descriptive and correlational study, the use of DREAM method for determination dermal exposure in chemotherapy personnel was investigated in Shahid Sadoughi University of Medical Sciences and Health Services. By assessment of probability and intensity emisson exposure, deposition exposour and transfer exposure for all of body parts calculated. Then, potential and actual exposure calculated and chemotherapy divisions classificated based on the DREAM average score, forthermore we assessed the correlation between various dermal exposure scores, occupational and demographical parameters.
Results: Maximum deposition dermal exposure (Mean=1.409, SD=0.127) was for the Baghaeepour division staff. Maximum transfer dermal exposure (Mean=3.500 , SD=0) was for the Imam Hassan division staff and maximum emmission dermal exposure (Mean=0.980 , SD=0.114) was for the Internal-1 division staff, respectively. The maximum potential and actual dermal exposure calculated (Mean= 5.133 , SD= 0) was for the Imam Hassan division staff and (Mean= 1.164 , SD= 0.152) ) for the Internal-1 division staff.
Conclusion: Depending on the findings although DREAM is a time-consuming and has somewhat complicated calculations to be used as a daily assessment tool, it can be used as an effective tool for initial assessment of the skin exposure in working environments.
Musculoskeletal disorders and correctional measures on fig gardeners in Estahban, 2017
Authors: Hooshyar A , Halvani GH , Fallah H , Zare H , Zeraatkar S
Published: November 2019

Introduction: Agriculture is one of the high-risk occupations, and musculoskeletal disorders are an integral part of this occupation and major farmers suffer from these disorders. The purpose of this study is correctional measures in Estahban.
Method: This descriptive-analytical, cross-sectional and observational study was performed on workers in the fig orchard. The Nordic, demographic and body map questionnaires were used to evaluate the prevalence of musculoskeletal symptoms. The study population was 170 randomly selected by simple random sampling. Subsequently, individuals who were exclusively working in the fig orchard (n = 95) were assessed for risk assessment. The methods for evaluating were PATH and QEC. Data were analyzed by SPSS software using McNemar and Wilcoxon tests before and after the intervention.
Results: Workers number 95 (55.9%) were only fig orchard workers and the other persons 75 (44.1%) had other jobs. workers 16 (9.4%) were single and 154 (90.6%) were married, mean age were 47.5 ± 14.4 years and work experience was 26.4 ±14.4 years. Frequency of musculoskeletal disorders in organs using body map was significantly different from before intervention (P <0.001). PATH risk level before and after the intervention was less than 0.05, in QEC method the mean total score before and after intervention was 94.36 ±16.09 and 52.63 ±12.18, respectively (P <0.001).
Conclusion: Ergonomic interventions can be used as a corrective action.
Identification and evaluation of human errors esing human factor analysis and classification system based on fuzzy hierarchy theory: a case study in the cement industry
Authors: Afshari D , Jafarzadeh Z , Mosavianasl Z , Jahani F
Published: November 2019

Introduction: Human factors studies have shown that about 80% of the root causes of major accidents have effected on safety, the environment or ergonomics are related to the human error. The purpose of this study was to identify human errors using the HFACS method and the FAHP theory in cement industry.
Methods: The present study was a retrospective study carried out in one cement industry of fars provience. At first, the RCA analysis of 95 incidents occurred during the past six years was prepared. Then, by integrating the human factors analysis and classification system technique) HFACS( and the theory of fuzzy analytic hierarchy process) FAHP( by 4 safety engineers of the factory was analyzed.
Results: The results of this study showed that the highest errors were related to the first level with the weight of 0.272, that was, the errors caused by unsafe acts, at this level of the subgroup of "skill-based error" with the weight of 0.269, the 2nd level of the sub-group of "industrial environment" with the weight of 0.155 , the 3rd subgroup of "inadequate supervision" with the weight of 0.352 and the 4th sub-category of "resource management" with the weight of 0.393 had the highest impact on the levels.
Conclusion: The results show that errors have various causes, including individual, activity, situational, and organizational errors that require careful planning and management to eliminate or reduce these errors. This error reduction, according to safety expert theory, health and environment of the cement plant, including the promotion and effectiveness of staff training, safety guidelines, improvement of staff performance monitoring, identification, evaluation and elimination of high-risk risks, improvement of management and equipment systems, changing safety attitudes, as well as enhancing safety attitudes. Awareness can help reduce the likelihood of human error in the organization.
Diagnosis and Ergonomic Design of Oxy Gas Welding Workstation by RULA Method. Case Study: Welding Workshops
Authors: Poorang H , Sadeghinaeini H , Ghousi R
Published: November 2019

Introduction: Working under non-ergonomic situations can cause physical damage. It's compulsory for the students of almost every engineering discipline to do parts of their training activitiy in various workshops including welding workstations, the paucity of appropriate situations in such workshops may lead to physical injuries. Ergonomic design of workstations can be considered a way to keep human health. The purpose of this study is an investigation on the application of ergonomic solutions in the design of workstations and Working situation improvement in oxy gaseous welding workshops.
Methods: In this study, workstations of the welding workshops in one of the public universities were selected as the case studies in 2015. The critical indicators of the current status of workstations were analyzed, using the CATIA V5 R21 software, the RULA method, and the proposed solutions.
Results: The results of the RULA clearly indicate a serious need to workstations's reform and Improve their level of safety. The Risk levels for the left and right hands were 6 and 7, which were decrease to 3 and 4 after redesigning the workplace and reforming its situations.
Conclusion: Studies and assessment indicate that during welding activities, postures of people cause serious injuries to various parts of the body, especially the spine. Therefore, workplace redesigning that is based on sit-stand workstation standards can be a suitable solution to correct the posture of people in welding workshops. Workstation redesigned involve some features such a increasing the dexterity and delicacy during welding and the proper use of Inclusive design factors to adjust the height of table, chair and the angle of table surface.
Measuring mercury in urine among students & professors at the faculty of dentistry exposed to mercury vapor by cold vapor atomic absorption technique
Authors: Mirmohammadi ST , Hosseinalipour SZ , Tirgar A , Shabankhani B
Published: November 2019

Introduction: Dentists are exposed to mercury vapor due to the occupational exposure to amalgam, which can endanger their health. The aim of this study was to determine the effect of mercury vapor on urinary mercury concentration of dental students and the restorative specialists in one of the dental schools of Iran.
Methods: The study population consisted40 dental students and 10 restoration specialists. Sample urine at the end of work time was collected, and the concentration of mercury in urine was measured by cold vapor atomic absorption spectrophotometry. A questionnaire was completed to determine the effects of some personal and environmental factors on the amount of urinary mercury. Data were analyzed using SPSS-22 software.
Results: The mean concentration of urinary mercury in dental students was 15.18±4.34μg/L and the restoration specialists were 4.11±1.05μg/l. In addition, there was a significant difference between the concentrations of urinary mercury in the two groups (P <0.001). At specialist professors there was a negative correlation between urinary mercury and working hours per day (r=-0.78, p=0.007). Also, in this study, there was a significant relationship between urine mercury and sex, age, type of amalgam consumed, consumption of smoking and the number of amalgam restorations.
Conclusion: The level of urine mercury in all samples was lower the recommended amount of ACGIH. The study is recommended mercury level monitoring for regularly evaluation of the workplace.
CONVERGENCE OF INSTITUTES OF FUNCTIONAL REPRESENTATION OF GROUP INTERESTS UNDER TRANSFORMATION OF SOCIAL PROCESSES, QUALITY OF LIFE, AND HUMAN CAPITAL
Authors: V. Tselyutina Tatyana , A. Vlasova Tatyana , A. Timokhina Olga , V. Maslova Yana
Published: November 2019

Purpose: This article substantiates the influence of mechanisms, methods, and technologies of a functional representation of group interests on the strategic management of socio-economic processes in the context of geopolitical turbulence.

Methodology: The work defines the socio-stratification basis for the representation of group interests, their role as subjects of representation in the modern system of management of social processes, the features of the convergence of functional representation of various interest groups, first of all, the multiform structures of the consulting and expert system, and ways to improve their performance subject to current reforming trends towards improvement of the quality of life and update of the importance of human capital..

Result: The authors determined the dependence of the results of managing socio-economic processes, the strategy of sustainable economic development of Russia on the degree of conscious complicity, social activity of the population and the presence of relevant institutions of functional representation of group interests, transparent (open, mutually beneficial, corruption-free) management mechanisms of a particular region. Government authorities, functional representation institutions can use the scientifically based recommendations proposed by the authors in the development of socio-economic projects and programs aimed at effective, first of all, regional development, and at the establishment of open channels of interaction in a “society - business - state” symbiosis. The article will also be of assistance to the scientific community as a theoretical justification of practical actions aimed at developing the institutions of a functional representation of group interests

Applications: This research can be used for the universities, teachers, and students.

Novelty/Originality: In this research, the model of convergence of institutes of a functional representation of group interests under transformation of social processes, quality of life, and human capital is presented in a comprehensive and complete manner.
Preventing ways to minimize probabilities of corruption in LNGOs in Iraq
Authors: Kakahama Amanj Lateef
Published: November 2019

Purpose:  the fragile of economic and political situations, weakness and instability in any country is a potential suitable medium to create and develop corrupted environment. Corruption minimizes the opportunity to funding projects in corrupted working environment. Typically the traditional image of local none government organizations leads to trust them, meanwhile the possibility of conducting corruption in these organizations is not far away from the staff. For example some directors or supervisors cheat the staff and seduce them to burn rate acts to show progress in the project, some mangers want to involve the staff in corrupted acts. This research arranged to minimize the potential corruption opportunities in local none government organizations in Iraq. 

Methodology: quantitative methodology was implemented. 29 questions plus participants` comment were arranged to be answered within 15 to 20 minutes. The collected data is primary data about the local none government organization current administration and professional state in Iraq.

Finding: Level of corruption could be noted in the local none government organizations and based on the collected data this corruption is result of: a) lack of comprehensive and professional code of conduct / internal policy and b) absent of best practice and international criteria in managing and producing organization issues at daily bases. Based on the participants feedbacks international none government organizations are recommended to support building professional work environment in the local none government organizations in Iraq.
Investigation of Photochromic Fluorescence Features and Synthesis of Diarylethene Type Naphthalimide Compounds
Authors: ORHAN Ersin , NARİN Mustafa
Published: November 2019

The aim of the study was to synthesise novel
photo-exchangeable photochromic fluorescence compounds. Starting from N-butyl-4-bromo-3-iodo-1,8-naphthalimide
new
compounds: 3,4-Bis(3,5-dimethyl-4-pyrazolyl)-N-butyl-1,8-Naphthalimide
6 and 3,4-Bis (1,3,5-trimethyl-4-pyrazolyl)-N-butyl-1,8-Naphthalimide
7 were prepared via two step Suzuki coupling reaction of
pyrazolyl boronic acid esters, and characterized by 1H-NMR, 13C-NMR,
MS and FTIR. Their photochromic fluorescence properties were investigated.

Additionally,
a solvent effect on the fluorescence properties of 6 and 7 was
investigated. Increase of organic solvent polarity results in a red shift (to
longer wavelengths) of the fluorescence emissions.
The acceleration of collagen biodegradation after adsorption of mesenchymal multipotent stromal cells in experiment
Authors: Maiborodin I. V. , Khomenyuk S. V. , Mikheeva T. V. , Yarin G. Yu. , Maiborodina V. I. , Vilgelmi I. A. , Shevela A. I.
Published: November 2019

Background. The scientific literature contents clearly not enough data at interaction of collagen materials with a living organism and about influence of multipotent stromal cells (MSC) on this process. There are controversies about the collagen degradation and the development of foreign body reactions. However, without account these results, it is impossible to estimate the timeframes for complete lysis of such materials, to progress effective methods for the prevention and treatment of developing complications. Objective. To study the features of the collagen-based material degradation after implantation with adsorbed autologous mesenchymal MSC of bone marrow origin (AMMSCBMO) in the experiment. Design and methods. In different times the condition of tissues around the implanted collagen membrane with adsorbed AMMSCBMO was studied by method of light microscopy. Results. The number of vessels and cellular elements in the collagen material implanted without AMMSCBMO increases to 3 weeks and remains at this level until the end of the observation. A distinctive features of the use of collagen membrane with adsorbed AMMSCBMO are increased vascularization and cellular infiltration of the material in the first 2 weeks after surgery. This effect further leads to a more rapid degradation of all implanted collagen, including its more dense parts, but does not prevent the formation of multinuclear macrophages with fused cytoplasm. Conclusion. As a result of more significant vascularization and cellular infiltration caused by AMMSCBMO adsorbed on the surface of the collagen material, to the 4th week the entire implant is full destroyed and absorbed, and dense fibrous connective tissue is formed in its place. For the implantation into the body, one should choose the most homogeneous collagen materials, without areas of different density, as slowly degrading fragments can cause the development of granulomatous inflammation and the failure of the implantation procedure.
A Theological Review of Approaching Models in the Dialog of Faith and Science
Authors: Manogu Ridwanta
Published: November 2019

Scholars have been proposing numerous models in “reconciling” faith and science. All proposed models, generally, could be categorized into four approaches: conflict, independence, dialogue, and integration. Since models in approaching the dialog of faith and science, basically, express presuppositions of how someone view reality. In this essay, therefore, these models are reviewed in the light of how Christians should comprehend the reality through the Scripture: God reveals Himself in two ways, general and special. General revelation is the world as His creation, and special revelation is the His words that have been written in the Bible. Special revelation, fundamentally, is a metaphysical framework for Christians to understand God’s creation. As the result, approaching model which cohere to biblical concept of one truth is integration model, which is, as some scholars call, the reconstruction or paradigmatic approach.
McGrath, Alister E. Sejarah Pemikiran Reformasi
Authors: Warokka Risart Y. Y.
Published: November 2019

McGrath, Alister E. Sejarah Pemikiran Reformasi. Trans. Liem Sien Kie. Jakarta: Gunung Mulia, 2006. 384 pages. Rp. 95.500,-
AMYLOIDOSIS HEART IN ELDERLY
Authors: Dvoretsky L. I. , Karpova O. Yu. , Alexandrova E. N. , Petrova S. Yu.
Published: November 2019

The data on the incidence, clinical presentation, diagnostic methods amyloidosis of the heart in different types of amyloidosis. The features of the current heart amyloidosis, highlights the difficulty of diagnosis and differential diagnosis in the elderly. As an illustration, describes a clinical case of amyloidosis of the heart in 83-year-old patient, the main manifestation of which was congestive heart failure.
Crystal Period Vectors under External Stress in Statistical Physics
Authors: Liu Gang
Published: November 2019

In crystal periodic structure prediction, a general equation is needed to determine the period vectors (cell edge vectors), especially when crystals are under arbitrary external stress. It has been derived in Newtonian dynamics years ago, which can be combined with quantum mechanics by further modeling. Here we derived such an equation in statistical physics, applicable to both classical physics and quantum physics by itself.
Strengthening Participation using Interactive Planning Support Systems: A Systematic Review
Authors: Flacke Johannes , Shrestha Rehana , Aguilar Rosa
Published: November 2019

Interactive Planning Support Systems (PSS) implemented on a maptable are deemed suitable to support participatory planning processes. Through their interactive nature and user-friendly interface they are supposed to facilitate exchange of knowledge between stakeholders, consensus building among them, group learning processes, and thereby strengthen participation. We analyze in this systematic review, based on 16 case studies using interactive PSS, how such PSS have contributed to the goal of strengthening stakeholder participation. Results show that tools and applications have become more sophisticated in recent years and the goals of the studies changed from collaboratively designing interventions to observing and understanding how the application of such tools contributes to improved plan outcomes and group based learning. However, many case studies lack a proper framework and operationalization for investigating the impacts of the tools and applications on participation. Consequently, impacts on participation are assessed rather incidentally based on implicit assumptions and often no distinction is made between the different aspects of participation. In conclusion, further theoretical studies conceptualizing impacts of interactive PSS on participation are needed as well as empirical studies testing these impacts in real world case contexts with various groups of stakeholders.
Case Study of Nephritis in Domestic Cats (Felis Catus) Male in Animal Education Clinic of Hasanuddin University
Authors: Monica Waode Santa , Octaviyani Indah Windy , Musdalifah Musdalifah
Published: November 2019

ABSTRACT: A pet such as a domestic cat (Felis Catus) with a sterile male sex aged 1 year 7 months with a body weight of 3.7 kg where the animal is affected by urinary system disorders namely Nephritis. Nephritis is kidney inflammation that can occur in the glomerulus, pyelum or tubules. Clinical symptoms shown in patients include polyuria, decreased appetite, and vomiting. For the diagnosis of Nephritis clinically evaluated based on changes in urination behavior, palpation of the dorsal abdominal caudal thoracic is temporarily labored based on a urine dipstick test containing protein ++ (± 100 mg / dL), leukocytes valued at +, urine specific gravity of 1,015 while based on ultrasound examination thickening of the renal cortex, medullary and cortical border is not apparent, renal size is 4.21 cm, kidney capsules that appear hyperechoic, and ascites in the abdomen. Cats treated with isotonic fluid infusion fluids, wet and dry diet diets, antibiotics, multivitamins, and anti-inflammatory. Inpatient animals for 4 days showed improvement in clinical symptoms, namely drinking quite well, starting to stand up, there was movement for activities, and urine was clearer.
PERAN MA’RUF AMIN DALAM MERAIH SUARA MASYARAKAT MUSLIM PADA PEMILIHAN PRESIDEN 2019
Authors: SANUSI AHMAD , Gumilar Galih
Published: November 2019

The appointment of Ma’ruf Amin as Jokowi’s running mate in the presidential election of 2019 resulted in pros and cons among political elites in the country. This paper, thus, aims at explaining the dynamic of political communication that allowed the appointment of Ma’ruf Amin as Jokowi’s running mate in the election. This paper concludes that Ma’ruf Amin has a unique political position among amny other potential running mates. As a senior ulama with records of political positions during his career, Ma’ruf Amin has the potential to boost votes for Jokowi in the upcoming election, especially from the traditional Muslim of Nahdatul Umala, the largest Muslim organisation in the country, and in the world. Moreover, by appointing Ma’ruf Amin, one of the highest rank ulamas in Nahdatul Ulama, Jokowi can get rid of the stigma of himself being not friendly to Islam as he has been target of black campaigns for years.Keywords: Indonesian Presidential Election, Ma’ruf Amin effect, and political communication.
MENGADU GAGASAN LEWAT IKLAN (Analisis Semiotika Political Campaign Jokowi dan Prabowo)
Authors: Ruhany Thibbur
Published: November 2019

The 2019 election is so special, apart from the rising political temperature in Indonesia, the elections is also like a rematch of the 2014 elections that brought together two strong candidates, Joko Widodo and Prabowo Subianto as presidential candidates. Each candidate collides with ideas to win public sympathy and influence voter behavior through political advertising. This study will examine the ideas of Jokowi and Prabowo's government through political advertising. The advertisement that will be used as the main analytical material in this paper is political advertising on social media through the Youtube platform, namely the Sarjana Kerja Kerja Kerja! and the advertisement of Arwah si Manis Jembatan Ancur. Findings suggest that in packaging the ideas related to their campaign programs, each candidate has different communication styles and approaches. Sarjana Kerja Kerja Kerja! contains criticism of Indonesia Kerja slogan. This advertisement conveys reality criticism that is not in accordance with Jokowi's Nawacita expectations and offers solutions to changes in the economic system, prosperous, and independent Indonesia. Whereas through the political campaign si Manis Jembatan Ancur, a message was found on the success of infrastructure development in the Jokowi era which was not only focused on big cities but also to remote villages as illustrated in the background of the advertisement. In this advertisement there is a campaign content where one of them is the figure of cleric who has many similarities with Jokowi's vice-presidential candidate, K.H. Ma'ruf Amin is synonymous with santri. Key Words; Semiotics, Sanders Pierce, Political Campaign, Jokowi Prabowo
Paroxetine suppresses reactive microglia-mediated but not lipopolysaccharide-induced inflammatory responses in primary astrocytes
Authors: Zhang Xiong , Zhu Lan-Bing , He Jia-Hui , Zhang Hong-Qiu , Ji Shu-Ya , Zhang Chao-Nan , Hou Na-Na , Huang Chen-Ping , Zhu Jian-Hong
Published: November 2019

Background Astrocytes are the most abundant glial cells in a brain that mediate inflammatory responses and provide trophic support for neurons. We have previously disclosed that paroxetine, a common selective serotonin reuptake inhibitor, ameliorates LPS-induced microglia activation. However, it remains elusive of the role of paroxetine in astrocytic responses. Methods Isolated primary astrocytes were pretreated with paroxetine and stimulated with different stimuli, lipopolysaccharide (LPS) or microglia conditioned medium pre-activated with LPS (M/Lps). Inflammatory and neurotrophic responses, underlying mechanisms and the impact on neuronal survival were assessed. Results Paroxetine had no impact on LPS-stimulated iNOS, TNF-α and IL-1β expression, but inhibited M/Lps-induced TNF-α and IL-1β expression in primary astrocytes. Paroxetine suppressed M/Lps- but not LPS-induced activation of NF-κB and had no impact on activation of MAPKs and STAT3. Incubation with the resulted astrocyte conditioned media caused no change in viability of SH-SY5Y cells. BDNF and MANF mRNA expressions were upregulated by M/Lps and paroxetine, respectively. However, M/Lps- or LPS-induced extracellular releases of NO, TNF-α and/or BDNF in astrocytes were in minor amount compared to those by microglia. Conclusions Paroxetine ameliorates the reactive microglia-mediated inflammatory responses in astrocytes partially via inhibition of NF-κB pathway, but has no impact on LPS-stimulated astrocyte activation. While the secondary astrocytic responses are not robust compared to the innate immune responses of microglia, our results support a therapeutic potential of paroxetine against neuroinflammation-associated neurological disorders such as Parkinson’s disease.
Transcriptomic analyses reveal putative genes associated with bibenzyl biosynthesis in the traditional Chinese herb Dendrobium officinale
Authors: Adejobi Oluwaniyi Isaiah , Guan Ju , Yang Liu , Hu Jiang-Miao , Yu Anmin , Muraguri Sammy , Wang Yaqin , liu aizhong
Published: November 2019

Background: Dendrobium plants are well known for their uses in traditional Chinese herbal medicine. Bibenzyl compounds are the main active compounds in Dendrobium officinale. However, the physiological and molecular basis for the biosynthesis of bibenzyl compounds in Dendrobium plants remains underexplored. Results: In this study, the accumulation of erianin and gigantol were studied as representative compounds of bibenzyl. Their presence in plant tissues were investigated. Our results show that root tissues contained the highest content of bibenzyl (erianin and gigantol). Based on the pre-experimental result that exogenous application of Methyl-Jasmonate promotes the biosynthesis of bibenzyl compounds in D. officinale root tissues, comparative transcriptomic analyses were conducted between the bibenzyl-accumulated root tissues and a control. In total, we identified 1,342 differentially expressed genes (DEGs) with 912 up-regulated and 430 down-regulated genes. Most of the identified DEGs are functionally involved in the JA signaling pathway and the biosynthesis of secondary metabolites. In particular, we identified 11 enzymatic genes functionally involved in bibenzyl biosynthesis.Conclusions: Our study provide insights on the identification of putative genes associated with bibenzyl biosynthesis and accumulation in Dendrobium plants, and also paves the way for future research on dissecting the physiological and molecular mechanisms of bibenzyl synthesis in plants as well as on how to best utilize genetic engineering and molecular modification techniques to genetically improve Dendrobium varieties by increasing the content of bibenzyl for drug production and industrialization. Keywords: Bibenzyl, D. officinale , Differentially expressed genes, Secondary metabolites, Transcriptome analysis.
New molecules for organic photovoltaic and solar cell applications based on N-(7-imidazolyl) -aryl sulfonamides by DFT and TD-DFT Methods
Authors: Lakrikh Siham , Atmani Hajar , Laallam Latifa , Jouaiti Ahmed
Published: November 2019

In this work, we use theoretical methods DFT density functional theory to calculate the electronic properties of the five molecules based on N- (7-indazolyl) -aryl sulfonamides, for an example of these parameters: HOMO energies, Energies of LUMO and E gap which are very interesting in the photovoltaic field. At the same time, we explore our result to achieve our goal of treminations the electronic and spectroscopic properties of these organic molecules through the use of TD-DFT, to determine the wavelengths of the molecules and to trace the visible, ultra-violet spectrum and to determine the transition states.
Effect of a Pedometer-based Walking Intervention on Body Composition in Patients with ESRD: A Randomized Controlled Trial
Authors: Sheshadri Anoop , Kittiskulnam Piyawan , Lai Jennifer C. , Johansen Kirsten L.
Published: November 2019

Background: A randomized trial of a pedometer-based intervention with weekly activity goals led to a modest increase in step count among dialysis patients. In a secondary analysis, we investigated the effect of this intervention on body composition.Methods: 60 dialysis patients were randomized to standard care or a 6-month program consisting of 3 months of pedometers and weekly step count targets and 3 months of post-intervention follow-up. We obtained bioelectrical impedance spectroscopy (BIS) data on 54 of these patients (28 control, 26 intervention) and used linear mixed-modeling (adjusted for sex and dialysis modality) to estimate differences in change in total-body muscle mass (TBMM) adjusted for height2, fat mass (kg), and body mass index (BMI) (kg/m2) between control and intervention groups.Results: The median age of participants was 57.5 years (53 – 66), 76% were men, and median dialysis vintage was 3.3 years (1.2 – 5.8). At baseline, there was no significant difference between groups in age, BMI, race, or body composition, but there were more men in the intervention group. After 3 months, patients in the intervention group in this BIS analysis increased their average daily steps by 2,414 (95% CI 1047, 3782) more than controls (p<0.001). At 6 months, participants in the intervention had a significantly greater increase in TBMM of 0.7 kg/m2 (95% CI 0.3, 1.13), decrease in fat mass (‑4.3 kg [95% CI ‑7.1, ‑1.5]) and decrease in BMI (-1.0 kg/m2 [95% CI -1.8, -0.2]) relative to controls. In post-hoc analysis, each increase of 1,000 steps from 0 to 3 months was associated with a 0.3 kg decrease in fat mass (95% CI 0.05, 0.5) from 0 to 6 months, but there was no dose-response relationship with TBMM/ht2 or BMI.Conclusion: A pedometer-based intervention resulted in greater decreases in fat mass with relative preservation of muscle mass, leading to a greater decrease in BMI over time compared with patients not in the intervention. These differences were driven as much by worsening in the control group as by improvement in the intervention group. Step counts had a dose-response relationship with decrease in fat mass.Trial Registration: ClinicalTrials.gov (NCT02623348). 02 December 2015. https://clinicaltrials.gov/ct2/show/NCT02623348
Acceptable short-term outcomes after open heart surgery in kidney transplant recipients: a case control study
Authors: Witczak Bartlomiej Jozef , Svennevig Jan L. , Hartmann Anders , Fiane Arnt E. , Åsberg Anders
Published: November 2019

Background
Cardiovascular disease is common in kidney transplant recipients. They are considered high risk surgery candidates due to comorbidity and immunosuppression. We assessed short-term results of open-heart surgery in kidney transplant recipients and matched controls between 1989 – 2016 at our center.
Methods
Ninety-five patients underwent open heart surgery (48 coronary artery bypass grafting, 27 valve replacements or repairs and 29 combined procedures) after kidney transplantation. Controls (n=95) were matched for age, sex, type and year of surgery. Mean follow-up was 5.6 (4.9) years. Independent two-sample t-test and chi-square test were used to compare continuous variables and frequencies, respectively. Logistic regression was used to identify preoperative risk factors for 30-day mortality.
Results
Included were 76 men and 19 women; mean age 60.3 (11.1) years, 7.1 (5.6) years after transplantation. Kidney transplants had lower renal function, more hypertension, but less pulmonary hypertension than matched controls. Intraoperative data was comparable between kidney transplants and controls. Kidney transplants experienced more frequent acute kidney injury (57% versus 23%, p<0.001), more bleeding (1288 (1081) mL versus 957 (548) mL, p=0.01) and more red cell transfusions (4.9 (5.6) versus 3.2 (5.4) units, p=0.04). Infections were borderline more frequent in kidney transplants (30% versus 20%, p=0.10). Thirty-day mortality was 6.3% in kidney transplants and 2.1% in controls (p=0.14). Independent risk factors for 30-day mortality were acute myocardial infarction last 90 days before surgery (OR 12.5, p=0.02) and current smoking (OR 17.3, p=0.02).
Conclusions
Kidney transplant recipients undergoing cardiac surgery have acceptable short-term results compared with matched controls; 30-day mortality rates were similar. Careful peri- and postoperative management is, however, warranted as kidney transplant recipients experience more bleeding and higher frequency of AKI.
Predictive Value of Admission D-dimer for Contrast-induced Acute Kidney Injury and Poor Outcomes after Primary Percutaneous Coronary Intervention
Authors: Lin Kai-Yang , Chen Han-Chuan , Jiang Hui , Wang Sun-Ying , Chen Hong-mei , Wu Zhi-Yong , Jiang Feng , Guo Yan-Song , ZHU PENG-LI
Published: November 2019

DD was found to be associated with acute myocardial infarction (AMI) and renal insufficiency. However, it is uncertain whether DD is an independent risk factor of CI-AKI in patients undergoing pPCI.Methods We prospectively enrolled 550 consecutive patients undergoing pPCI between January 2012 and December 2016. The predictive value of admission DD for CI-AKI was assessed by receiver operating characteristic(ROC) and multivariable logistic regression analysis. CI-AKI was defined as an absolute serum creatinine increase ≥0.3 mg/dl or a relative increase in serum creatinine ≥50% within 48 h of contrast medium exposure.Results Overall, the incidence of CI-AKI was 13.1%. The ROC analysis showed that the cutoff point of DD was 0.69 ug/ml for predicting CI-AKI with a sensitivity of 77.8% and a specificity of 57.3%. The predictive value of DD was similar to the Mehran score for CI-AKI (AUC DD =0.729 vs AUC Mehran =0.722; p =0.8298). Multivariate logistic regression analysis indicated that DD >0.69 ug/ml was an independent predictor of CI-AKI (odds ratio[OR]=3.37,95%CI:1.80-6.33, p <0.0001). Furthermore, DD >0.69 ug/ml was associated with an increased risk of long-term mortality during during a mean follow-up period of 16 months(hazard ratio=3.41, 95%CI:1.4-8.03, p =0.005).Conclusion admission DD >0.69 ug/ml is a significant and independent predictor of CI-AKI and long-term mortality in patients undergoing pPCI.
The Therapeutic Effect of Corneal Transplantation for Refractory Pseudomonas Aeruginosa Corneal Ulcer
Authors: Li Yan , Wang Ting , Wang Qiang , Jiang Shanhao , Wang Xin
Published: November 2019

Purpose To observe the treatment outcome of corneal transplantation for advanced medically uncontrolled culture-proven pseudomonas aeruginosa corneal ulcer.Design Retrospective analysisSubjects and methods 26 patients (eyes) with refractory culture-positive pseudomonas aeruginosa corneal ulcer who failed to respond to drug therapy and underwent consecutive corneal transplant procedures in a hospital (2008.1-2018.8). Etiology, medical history, clinical features, surgical type, vision, recurrence, complications and treatment were recorded, and the relationship between postoperative recovery and selection of surgical method was analyzed.Results Of the 26 patients with pseudomonas aeruginosa corneal ulcer, 9 (34.6%) received penetrating keratoplasty (PKP) and 17 (65.4%) received lamellar keratoplasty (LKP). 22 patients (84.6%) obtained a successful outcome through one corneal transplantation. Of the 9 patients who received PKP, 1 patient having graft rejection 6 months after surgery (endothelial type) obtained successful outcome through adequate drug treatment., while 1 case received success by graft repair combined with amniotic membrane transplantation on the 5 months postoperatively for fungal corneal graft ulcer. In the 17 patients underwent LKP, 2 received a second successful lamellar corneal transplantation for corneal graft melting 2 months after the first surgery. In all the 26 patients, the corneal infection was effectively brought under control by corneal transplantation, and none of them had recurrent ulcers during at least 6months' follow-up. The visual acuity was significantly improved at the last follow-up compared with that before surgery. The postoperative visual acuity of patients underwent LKP was better than that of those who underwent PKP ( p =0.018).Conclusions Corneal transplantation can effectively treat refractory pseudomonas aeruginosa corneal ulcer worsening despite adequate medical treatment and improve eyesight. Compared with PKP, LKP can be the main surgical method to treat refractory pseudomonas aeruginosa corneal ulcer.
Title High Flow Nasal cannula oxygen therapy in a general pediatric (non-intensive care) setting
Authors: Kooiman Louise , Reimink Roelien , Langenhorst Veerle , Brand Paul , Bekhof Jolita
Published: November 2019

Background: High flow nasal cannula therapy (HFNC) is being used increasingly for oxygen delivery in children with impending respiratory failure, however solid evidence of its effectiveness is sparse. Moreover, data on safety regarding its use outside of the Pediatric Intensive Care Unit (PICU), with flowrates exceeding 1 L/kg is lacking. Methods: Retrospective chart review at the pediatric ward of Isala, a general teaching hospital in Zwolle, The Netherlands, 100 km away from the nearest PICU. All children <18 years with impending respiratory failure treated with HFNC between January 2015 and May 2016 were included. A flowrate of 2 L/kg/minute for the first 10 kg was used; with 0.5 L/kg for every kg >10 kg and a maximum of 50 L/min. A pediatric early warning score (PEWS) comprising vital functions and work of breathing (0-28 points) was used to assess severity of respiratory distress. Treatment failure was defined as referral to the PICU. Results: In the 16-month study period HFNC was used during 41 hospital admissions in 39 patients (64.1% male), median age 6.3 months (interquartile range, IQR 3–20.6). Median (IQR) PEWS at the start of HFNC was 8.5 (7–10). Patients were diagnosed with bronchiolitis (70.7%), pneumonia (24.4%) or asthma (4.9%). In 18 cases (43.9%) HFNC failed, with referral to a PICU. No clinical variables (age, comorbidity, PEWS at admission or start of HFNC) nor improvement of the PEWS after 2 hours of HFNC were associated with treatment failure. We found no association between treatment failure and the start of HFNC at an earlier stage or at lower PEWS (odds ratio 1.03; 95% confidence interval 0.82-1.30; p=0.80). There were no safety issues, no cases with air leak or other complications. Conclusions: This small study suggests that HFNC can be safely used and initiated in a general pediatric department. We were unable to find clinical factors that predicted HFNC success. We recommend not to restrict evaluation of the effect of HFNC in studies to short-term (2 hours), but also after longer duration, at least 24 hours.