bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Penambahan Herbafit Dalam Pakan Terhadap Kualitas Fisik Telur Ayam Ras Petelur
Authors: Rahmawati Nurina , Irawan Andri Cahya
Published: April 2021

Penelitian ini bertujuan untuk memahami efek herbafit yang ditambahkan dalam pakan tentang kualitas fisik telur ayam ras petelur yang meliputi berat telur, tebal kerabang telur, indeks putih telur, indeks kuning telur, warna kuning telur dan haugh unit telur. Materi penelitian ini berupa ayam ras petelur fase layer dengan strain Isa-Brown umur 28 minggu sebanyak 100 ekor, Fitobiotik (campuran antara tepung kunyit dan jahe dengan rasio masing - masing 5 : 5 : 1), konsentrat ayam petelur, kandang baterai sebanyak 20 kandang. penelitian ini menggunakan metode Rancangan Acak Lengkap (RAL) yang terdiri dari 4 perlakuan dan 5 Ulangan. Perlakuan yang diterapkan yaitu P0 : Pakan Basal (kontrol), P1 : Pakan Basal ditambah Herbafit 1% , P2 : Pakan Basal ditambah Herbafit 2%,, P3 : Pakan Basal ditambah Herbafit 3%. Hasil penelitian menyatakan penambahan herbafit sebanyak 3% memberikan pengaruh yang nyata (P<0,05) terhadap tebal kerabang telur, indeks kuning telur, warna kuning telur dan haugh unit telur. Namun penambahan herbafit dengan level 1 – 3% tidak memiliki pengaruh (P>0,05) terhadap berat telur dan indeks putih telur. kesimpulannya adalah penambahan herbafit sebanyak 3% dalam pakan dapat meningkatkan kualitas fisik telur ayam petelur meliputi kerabang telur, indeks kuning telur, warna kuning telur dan haugh unit.
Evaluasi Kualitas Kimia Kulit Ubi Kayu (Manihot Utilissima) yang Difermentasi Menggunakan Inokulan Aspergillus Oryzae
Authors: Saputri Marlia Dwita , Chuzaemi Siti
Published: April 2021

Penelitian ini dilakukan dengan tujuan untuk mengevaluasi tentang pengaruh tingkat penggunaan Aspergillus oryzae terhadap kualitas kimiawi fermentasi kulit ubi kayu (Manihot utilissima). Aspergillus oryzae dengan kadar pemakaian yang berbeda yaitu 0%, 1%, 2% dan 3% digunakan untuk fermentasi kulit ubi kayu dengan waktu inkubasi 96 jam. Penelitian ini menggunakan metode percobaan di laboratorium dengan Rancangan Acak Lengkap (RAL) yang terdiri dari 4 perlakuan dan 3 ulangan sehingga total berjumlah 12 unit. Kualitas kimia yang diamati dalam penelitian ini terdiri dari Bahan Kering (BK), Bahan Organik (BO), Serat Kasar (SK), Lemak Kasar (LK), Protein Kasar (PK) dan Bahan Ekstrak Tanpa Nitrogen (BETN). Analisis varian digunakan untuk menganalisis data hasil penelitian lalu dilanjukan dengan uji Uji Jarak Berganda Duncan (UJBD). Hasil penelitian menunjukkan bahwa penggunaan Aspergillus oryzae berpengaruh sangat signifikan terhadap nilai BK dan SK (P<0,05), PK dan BETN (P<0,01) tetapi tidak berpengaruh signifikan terhadap nilai BO dan LK (P>0,05). Kesimpulan dari penelitian ini adalah penggunaan Aspergillus oryzae 3% selama 96 jam untuk memfermentasi kulit ubi kayu merupakan cara terbaik untuk meningkatkan kandungan nutrisi meliputi kadar BK, BO dan BETN serta menurunkan kadar abu, SK dan LK.
Implementation of early and late fusion methods for content-based image retrieval
Authors:   Faculty of Computer Science and Information Technology, King Abdulaziz University, Jeddah, Saudi Arabia, Ahmed Ali , Mohamed Sara ,   Fuclty of Computer Science and Information Technology, Sudan University for Science and Technology, Khartoum, Sudan
Published: April 2021

Content-Based Image Retrieval (CBIR) systems retrieve images from the image repository or database in which they are visually similar to the query image. CBIR plays an important role in various fields such as medical diagnosis, crime prevention, web-based searching, and architecture. CBIR consists mainly of two stages: The first is the extraction of features and the second is the matching of similarities. There are several ways to improve the efficiency and performance of CBIR, such as segmentation, relevance feedback, expansion of queries, and fusion-based methods. The literature has suggested several methods for combining and fusing various image descriptors. In general, fusion strategies are typically divided into two groups, namely early and late fusion strategies. Early fusion is the combination of image features from more than one descriptor into a single vector before the similarity computation, while late fusion refers either to the combination of outputs produced by various retrieval systems or to the combination of different rankings of similarity. In this study, a group of color and texture features is proposed to be used for both methods of fusion strategies. Firstly, an early combination of eighteen color features and twelve texture features are combined into a single vector representation and secondly, the late fusion of three of the most common distance measures are used in the late fusion stage. Our experimental results on two common image datasets show that our proposed method has good performance retrieval results compared to the traditional way of using single features descriptor and also has an acceptable retrieval performance compared to some of the state-of-the-art methods. The overall accuracy of our proposed method is 60.6% and 39.07% for Corel-1K and GHIM-10K ‎datasets, respectively.
Machine Learning–Driven Models to Predict Prognostic Outcomes in Patients Hospitalized With Heart Failure Using Electronic Health Records: Retrospective Study
Authors: Lv Haichen , Yang Xiaolei , Wang Bingyi , Wang Shaobo , Du Xiaoyan , Tan Qian , Hao Zhujing , Liu Ying , Yan Jun , Xia Yunlong
Published: April 2021

Background

With the prevalence of cardiovascular diseases increasing worldwide, early prediction and accurate assessment of heart failure (HF) risk are crucial to meet the clinical demand.

Objective

Our study objective was to develop machine learning (ML) models based on real-world electronic health records to predict 1-year in-hospital mortality, use of positive inotropic agents, and 1-year all-cause readmission rate.

Methods

For this single-center study, we recruited patients with newly diagnosed HF hospitalized between December 2010 and August 2018 at the First Affiliated Hospital of Dalian Medical University (Liaoning Province, China). The models were constructed for a population set (90:10 split of data set into training and test sets) using 79 variables during the first hospitalization. Logistic regression, support vector machine, artificial neural network, random forest, and extreme gradient boosting models were investigated for outcome predictions.

Results

Of the 13,602 patients with HF enrolled in the study, 537 (3.95%) died within 1 year and 2779 patients (20.43%) had a history of use of positive inotropic agents. ML algorithms improved the performance of predictive models for 1-year in-hospital mortality (areas under the curve [AUCs] 0.92-1.00), use of positive inotropic medication (AUCs 0.85-0.96), and 1-year readmission rates (AUCs 0.63-0.96). A decision tree of mortality risk was created and stratified by single variables at levels of high-sensitivity cardiac troponin I (<0.068 μg/L), followed by percentage of lymphocytes (<14.688%) and neutrophil count (4.870×109/L).

Conclusions

ML techniques based on a large scale of clinical variables can improve outcome predictions for patients with HF. The mortality decision tree may contribute to guiding better clinical risk assessment and decision making.
Home Telemonitoring of Arterial Hypertension With Antihypertensive Treatment Titration: Protocol for a Randomized Controlled Prospective Trial (HOROSCOPE Study)
Authors: Ben Hafaiedh Sonia , Ben Daya Yosra , Radoui Amina Hadjer , Bouchoucha Mohamed , Razgallah Rabie , Nouira Semir
Published: April 2021

Background

Despite the availability of effective treatment, the control of hypertension remains insufficient. Telemonitoring in the management of hypertension would be an effective way to improve blood pressure control.

Objective

The aim of our study will be to evaluate the effects of telemonitoring with antihypertensive treatment titration on blood pressure control in Tunisian patients with hypertension.

Methods

Our trial will be a prospective, rater-blinded randomized controlled trial carried out with primary care physicians in the Sahel region of Tunisia. Patients will be eligible for enrollment if they are aged over 35 years, are newly diagnosed with hypertension, or are known to be poorly controlled on antihypertensive therapy. Participants will be randomly assigned in a 1:1 ratio to the telemonitoring arm or usual care arm. The telemonitoring arm will involve a weekly telephone call for the collection of the home blood pressure measurements, therapeutic education, and treatment compliance assessment as well as a monthly call for treatment titration and a side effect check. Randomization will be done via the use of an interactive web responsive system, and patients will be stratified by investigation center. Neither participants nor investigators will be masked to the group assignments. The primary outcome will be the change in mean 24-hour systolic blood pressure from baseline to the 6-month follow-up in the 2 groups. All randomized patients who attend the follow-up visit at 6 months and have no missing data for the primary outcome will be included in the analysis.

Results

Recruitment to the trial started in July 2020. The study was initiated with 17 primary care physicians. We expect the inclusion period to last for approximately 6 months. We expect to complete data collection by the end of 2021 and plan to disseminate the results subsequently.

Conclusions

The HOROSCOPE (Home Telemonitoring of Arterial Hypertension With Antihypertensive Treatment Titration: Randomized Controlled Prospective Trial) study will provide important new evidence that could shed some light on the feasibility and impact of telemonitoring and self-monitoring in a Tunisian population of patients with hypertension who consult primary care physicians.

Trial Registration

ClinicalTrials.gov NCT04607239; https://clinicaltrials.gov/ct2/show/NCT04607239

International Registered Report Identifier (IRRID)

DERR1-10.2196/26184
A Novel Metric to Quantify the Effect of Pathway Enrichment Evaluation With Respect to Biomedical Text-Mined Terms: Development and Feasibility Study
Authors: Qin Xuan , Yao Xinzhi , Xia Jingbo
Published: April 2021

Background

Natural language processing has long been applied in various applications for biomedical knowledge inference and discovery. Enrichment analysis based on named entity recognition is a classic application for inferring enriched associations in terms of specific biomedical entities such as gene, chemical, and mutation.

Objective

The aim of this study was to investigate the effect of pathway enrichment evaluation with respect to biomedical text-mining results and to develop a novel metric to quantify the effect.

Methods

Four biomedical text mining methods were selected to represent natural language processing methods on drug-related gene mining. Subsequently, a pathway enrichment experiment was performed by using the mined genes, and a series of inverse pathway frequency (IPF) metrics was proposed accordingly to evaluate the effect of pathway enrichment. Thereafter, 7 IPF metrics and traditional P value metrics were compared in simulation experiments to test the robustness of the proposed metrics.

Results

IPF metrics were evaluated in a case study of rapamycin-related gene set. By applying the best IPF metrics in a pathway enrichment simulation test, a novel discovery of drug efficacy of rapamycin for breast cancer was replicated from the data chosen prior to the year 2000. Our findings show the effectiveness of the best IPF metric in support of knowledge discovery in new drug use. Further, the mechanism underlying the drug-disease association was visualized by Cytoscape.

Conclusions

The results of this study suggest the effectiveness of the proposed IPF metrics in pathway enrichment evaluation as well as its application in drug use discovery.
Correction: A Novel Remote Follow-Up Tool Based on an Instant Messaging/Social Media App for the Management of Patients With Low Anterior Resection Syndrome: Pilot Prospective Self-Control Study
Authors: Liu Fan , Guo Peng , Su Xiangqian , Cui Ming , Jiang Jianlong , Wang Suo , Yu Zhouman , Zhou Runhe , Ye Yingjiang
Published: April 2021

In “A Novel Remote Follow-Up Tool Based on an Instant Messaging/Social Media App for the Management of Patients With Low Anterior Resection Syndrome: Pilot Prospective Self-Control Study” (JMIR Mhealth Uhealth 2021;9(3):e22647) the authors noted one error. Under “Acknowledgments”, first paragraph, the phrase “Grant No. 2145000042” should been replaced by “Grant No. 2017YF0908203”.
Обращение главного редактора
Authors: Nikonov V.V.
Published: April 2021

No abstract
Изменения функционального состава тромбоцитов у пациентов с политравмой
Authors: Vyshynska M.B.
Published: April 2021

Акутальность. Политравма остается главной причиной глобальной заболеваемости и смертности и является причиной более 10 % смертей. Цель: изучить данные литературы об изменениях показателей сосудисто-тромбоцитарного гемостаза у пациентов с политравмой, исследовать динамику морфофункционального состояния тромбоцитов, проанализировать изменения показателей внутрисосудистой активации тромбоцитов у пациента с политравмой. Результаты. Для нормального свертывания крови нужны как минимум 4 компонента — кровеносные сосуды, тромбоциты, способность крови к свертыванию и фибринолиз. Определение таких компонентов, как показатели внутрисосудистой активации тромбоцитов, может стать важным шагом оценки нарушений тромбоцитарного звена гемостаза у пациентов с политравмой. Сосудисто-тромбоцитарный гемостаз начинается рефлекторным первичным спазмом артериол, после чего возникает вторичный спазм артериол, дальше образуется первичная тромбоцитарная пробка (адгезия и агрегация) и, соответственно, консолидация тромба, в результате чего формируется окончательный тромбоцитарный тромб. Еще до контакта тромбоцитов с обнаженным коллагеном происходит первичная активация тромбоцитов. Сначала меняется форма интактных тромбоцитов с дискоидной формы к активированым клеткам — дискоэхиноцитам, сфероцитам и/или сфероэхиноцитам. Нами установлено, что на 3-и сутки после травмы при нормальном количестве тромбоцитов в венозной крови уменьшается количество интактных тромбоцитов — дискоцитов, растет количество активных форм тромбоцитов — дискоэхиноцитов и сфероэхиноцитов, соответственно, растет общая сумма активных форм тромбоцитов. Нормальный уровень тромбоцитов у пациентов с политравмой может замаскировать выраженность коагулопатии, а проведение исследований показателей внутрисосудистой активации тромбоцитов может стать диагностическим компонентом сосудисто-тромбоцитарного звена гемостаза у пациентов с политравмой. Выводы. У пациентов с коагулопатией вследствие политравмы на 3 сутки наблюдаются изменения показателей внутрисосудистой активации тромбоцитов и агрегации тромбоцитов, индуцированной адреналином и АДФ.
Улучшение исходов ишемического инсульта у пациентов с высоким уровнем свободного трийодтиронина по сравнению с пациентами с гипо- и эутиреозом
Authors: Filimonov D.O. , Yevtushenko I.A.
Published: April 2021

Актуальность. Известно, что дисфункция щитовидной железы ассоциирована с повышенным риском развития цереброваскулярных заболеваний. Однако накопленные в течение последних лет экспериментальные данные свидетельствуют о том, что гормоны щитовидной железы могут иметь определенные нейропротекторные эффекты. Цель исследования: определить взаимосвязь между уровнем свободного трийодтиронина в дебюте острого ишемического инсульта и функциональным исходом инсульта через 6 месяцев. Материалы и методы. В исследование был включен 121 пациент с впервые развившимся острым ишемическим инсультом. Концентрации свободного трийодтиронина (свT3), свободного тироксина (свT4), тиреотропного гормона и наличие базисных факторов риска инсульта оценивались в течение 24 часов с момента появления симптомов. Неврологический дефицит оценивался по Скандинавской шкале инсульта (SSS). Неблагоприятный функциональный исход определялся как показатель mRs ≥ 3 баллов через 6 месяцев после перенесенного инсульта. Результаты. Тест ANOVA показал, что пациенты с уровнем свT3 в 4-м квартиле (≥ 5,35 пмоль/л) имели значительно более тяжелый неврологический дефицит по сравнению с пациентами с уровнем свТ3 во 2–3-м квартилях (медиана SSS 48 баллов против 37 баллов, p = 0,0481) и особенно по сравнению с пациентами с уровнем свТ3 в 1-м квартиле (≤  3,4050 пмоль/л, медиана SSS 48 против 30, p = 0,0018). Согласно тесту Краскала — Уоллиса, пациенты с уровнем свободного Т3 выше 75-го процентиля имели более благоприятный функциональный исход со средним значением по модифицированной шкале Рэнкина 2,5 балла по сравнению с пациентами с уровнем свT3 в 25–75-м процентилях (со средним значением по модифицированной шкале Рэнкина 4 балла). Результаты анализа пробит-регрессии свидетельствуют о дозозависимом влиянии уровня свT3 на вероятность благоприятного исхода инсульта. Уровень свободного Т3 6,56 пмоль/л был связан с 50% вероятностью благоприятного исхода, а уровень свободного Т3 выше 8,67 пмоль/л был ассоциирован с 75% вероятностью благоприятного исхода инсульта. Выводы. Исследование показало, что пациенты с высоким уровнем свободного трийодтиронина при дебюте ишемического инсульта имеют более благоприятный функциональный исход, даже по сравнению с пациентами с нормальным уровнем свободного Т3. Более высокие уровни свободного трийодтиронина также ассоциируются с менее тяжелым неврологическим дефицитом в острой фазе. Выявлено дозозависимое влияние уровня свободного трийодтиронина на вероятность благоприятного исхода инсульта. Полученные данные свидетельствуют о том, что тиреоидный профиль является не только фактором, влияющим на течение ишемического инсульта, но и потенциальной мишенью для терапевтической коррекции.
Технологии сохранения функции почек у пациентов с хронической болезнью почек и гиперурикемией
Authors: Ivanov D.D. , Bevzenko T.B. , Kushnirenko S.V. , Rotova S.A.
Published: April 2021

Распространенность хронической болезни почек (ХБП) и гиперурикемии глобально возрастает. Неуклонное увеличение количества пациентов с нарушенной функцией почек на фоне сахарного диабета, артериальной гипертензии и увеличения продолжительности жизни в конечном итоге приводит к значительным расходам, связанным с необходимостью использования дорогостоящих методов почечно-заместительной терапии. Основной задачей для врачей является своевременное определение и замедление прогрессирования ХБП, проведение ренопротекции. Гиперурикемия рассматривается как независимый фактор риска возникновения и прогрессирования болезни кроме традиционных на сегодняшний день микроальбуминурии и снижения скорости клубочковой фильтрации. Актуальность выявления гиперурикемии обусловлена возможностью ее дальнейшей коррекции для улучшения прогноза заболевания и отсрочки конечной стадии ХБП, повышения качества жизни и уменьшения затрат на лечение пациентов. Уменьшение общего пула мочевой кислоты в организме способствует минимизации риска артропатии и нефролитиаза, обострения подагры, прогрессирования почечной недостаточности и других осложнений. Однако, несмотря на сотни опубликованных клинических исследований, посвященных вопросам диагностики и лечения больных с ХБП, качество помощи остается неоптимальным. В статье представлены разносторонние взгляды на технологии сохранения функции почек у пациентов с ХБП и гиперурикемией, требующие усовершенствования.
Организация диетического питания путем энтерального кормления через зонд у детей с хроническими заболеваниями почек 2-5-й стадии и на диализе: рекомендации по клинической практике от Рабочей группы по вопросам детского нефрологического питания
Authors: Authors No
Published: April 2021

No abstract
Руководство по клинической практике для управления артериальным давлением при хронической болезни почек KDIGO 2021: резюме рекомендаций
Authors: Authors No
Published: April 2021

No abstract
Autecology of Begonia in Several Locations of Flores Island
Authors: Sutomo Sutomo , Iryadi Rajif
Published: April 2021

Human activities in forest areas such as over-harvesting of Begonia species without being balanced with their cultivation activities can threaten the existence of Begonia in nature. Autecological studies of species in their natural habitat are the initial activities for the conservation of plant species. The purpose of this study was to study the distribution of Begonia on Flores and environmental/ microclimate characteristics in several locations on Flores Island. The 10x10 m plots were placed with purposive sampling with a minimum interval of 50 m. Multivariate analysis using Canonical Corespondence Analysis (CCA) was employed to determine the effect of microclimatic factors on the composition of vegetation. Begonia kelimutensis is endemic in Kelimutu National Park, Flores lives at an altitude of 1,527 asl, at soil pH 5,8 and soil moisture of 75%, with a slope of 10 ° on the forest floor and light intensity 4,640 klux. In addition, five types of Begonia that we estimate have not been identified and two of them are identified as Begonia sumbawaensis Girm. and Begonia brangbosangensis Girm. Begonia kelimutuensis is distributed at a higher altitude than Begonia brangbosangensis. B. sumbawaensis is influenced by the slope factor while B. longifolia tends to be related to the air humidity factor. B. kelimutuensis is also often found living with Macaranga sp., and Litsea sp. B. brangbosangensis, also found near Homalanthus sp. and Calliandra callothyrsus.
Exploring the Drivers of Corrupt Practices and Non-Adherence to Ethical Values in Public-Sector Management: Focusing on Public Policy and Programme Implementation
Authors: Damoah Isaac Sakyi , Ayakwah Anthony
Published: April 2021

This study explores the drivers of corrupt practices and non-adherence to ethical values in public management operations by focusing on public policy and programmes implementation within the Ghanaian context. Evidence based on an in-depth semi-structured interview (32) and focus-group discussions (2) found several drivers of corrupt practices and non-adherence to ethical values; which suggests an intertwined and cyclical relationships among the drivers. We find institutions, administration systems and political as fundamental drivers whilst socio-culture and economic as secondary drivers. However, political leadership is fundamental whilst management leadership from contracting firms are secondary drivers.
Basarab loop and the generators of its total multiplication group
Authors: Jaiyéolá Temitope , Effiong Gideon
Published: April 2021

A loop (Q; ·) is called a Basarab loop if the identities: (x · yxρ)(xz) = x · yz and (yx) · (xλz · x) = yz · x hold. It was shown that the left, right and middle nuclei of the Basarab loop coincide, and the nucleus of a Basarab loop is the set of elements x whose middle inner mapping Tx are automorphisms. The generators of the inner mapping group of a Basarab loop were refined in terms of one of the generators of the total inner mapping group of a Basarab loop. Necessary and su_cient condition(s) in terms of the inner mapping group (associators) for a loop to be a Basarab loop were established. It was discovered that in a Basarab loop: the mapping x ↦ Tx is an endomorphism if and only if the left (right) inner mapping is a left (right) regular mapping. It was established that a Basarab loop is a left and right automorphic loop and that the left and right inner mappings belong to its middle inner mapping group. A Basarab loop was shown to be an automorphic loop (A-loop) if and only if it is a middle automorphic loop (middle A-loop). Some interesting relations involving the generators of the total multiplication group and total inner mapping group of a Basarab loop were derived, and based on these, the generators of the total inner mapping group of a Basarab loop were finetuned. A Basarab loop was shown to be a totally automorphic loop (TA-loop) if and only if it is a commutative and exible loop. These aforementioned results were used to give a partial answer to a 2013 question and an ostensible solution to a 2015 problem in the case of Basarab loop.
Las lecciones de Fernando de Fuentes
Authors: García Gustavo
Published: April 2021

Ensayo sobre de uno de los precursores del cine mexicano de llamada “Época de Oro”, Fernando de Fuentes, formado en la clase media ilustrada del porfiriato, deviene es uno de los más agudos críticos de la Revolución Mexicana que busca con sus temas definir en el cine “lo mexicano”, de manera paralela a lo que se hacía en la pintura o en la literatura. Destacan entre sus cintas Prisionero 13, ¡Vámonos con pancho Villa! y El compadre Mendoza. El autor de este artículo fue uno de los más destacados analistas del cine mexicano.
Injection into the shallow aquifer-aquitard system beneath Mexico City for counteracting pore pressure declines due to deeper groundwater withdrawals: Analysis of one injection well
Authors: Vázquez-Guillén Felipe , Auvinet-Guichard Gabriel
Published: April 2021

Los acuíferos están siendo severamente sobre-explotados en muchas partes del mundo conforme al continuo aumento de las poblaciones urbanas. Además, la excesiva extracción del agua subterránea de los acuíferos ha acelerado dramáticamente la consolidación de los acuitardos sobre-yacientes, creando severos hundimientos del terreno y muchos otros problemas relacionados. La Ciudad de México, con una población de 20 millones de habitantes y un acuífero principal exhausto, es un sitio que ofrece excelentes condiciones para experimentar técnicas de compensación. En este artículo, se propone una estrategia con el propósito específico de mitigar el hundimiento del subsuelo de la Ciudad de México. La estrategia consiste en aumentar la presión de poro en el acuífero somero por debajo de la Ciudad de México con la intención de inducir un proceso de difusión a través de los acuitados superior e inferior, para generar incrementos de presión de poro en el sistema que contrarresten los actuales descensos de presión de poro asociados a las extracciones de agua subterránea en la unidad acuífera principal. La estrategia se analiza analíticamente y se utilizan parámetros hidráulicos típicos del sistema acuífero-acuitado somero por debajo de la Ciudad de México sujeto a un pozo de inyección. Los resultados proporcionan, por primera vez, las respuestas hidráulicas acopladas del sistema sujeto a la inyección de agua y proporcionarán datos útiles cuando se realicen pruebas de inyección en el futuro cercano.
Spectrum of Bacterial Infections Associated with Diabetic Ulcer Patients
Authors: Pany Swatishree , Sen Shibani Kumar , Prasanna G. , Pati S. , Pal Bibhuti Bhusan
Published: April 2021

Diabetic ulceration is a multi-factorial problem which is responsible for considerable morbidity threatening the health care system. By knowing the clinical profile and bio-burden on diabetic ulcer, it is highly beneficial for health treatment. The purpose of the present study was to evaluate the diversity of major bacterial etiology in diabetic ulcer patients. The different samples like pus, swab, and infected tissues were collected from diabetic ulcer patients aseptically and samples were transported through cold chain to the laboratory. The samples were cultured in nutrient agar, mannitol salt agar, macConkey agar and blood agar. Suspected colonies were biochemically confirmed for the isolation of Staphylococcus aureus, Pseudomonas aeruginosa, E.coli and Klebsiella spp. In total 150 diabetic ulcer patients suffering from diabetic foot ulcers, gangrene, burn cases and accidental ulcer cases were analyzed. However, most of the patients developed mono-microbial infection; S.aureus was the most prevalent microbe in diabetic ulcer cases, which were positive for nucA gene.
Therapeutic and Biomedical Potentialities of Terpenoids – A Review
Authors: Jahangeer Muhammad , Fatima Rameen , Ashiq Mehvish , Basharat Aneela , Qamar Sarmad Ahmad , Bilal Muhammad , Iqbal Hafiz M.N.
Published: April 2021

Terpenoids are the most diverse and largest class of chemicals of the innumerable plant-based compounds. Plants carry out a number of essential growth and production functions using terpenoid metabolites. In contrast, most terpenoids are used in the abiotic and biotic systems for complex chemical interactions and defense. Terpenoids derived from plants mostly used humans for pharmaceutical, food, and chemical industries in the past. However, recently biofuel products have been developed by terpenoids. The metabolism of high-quality terpenoids in plants and microbes is facilitated in synthetic biology by genomic resources and emerging tools. Further focus has been given to the ecological value of terpenoids for establishing effective pesticide control approaches and abiotic stress protection. The awareness of the diverse metabolic and molecular regulatory networks for terpenoid biosynthesis needs to be increased continuously in all these efforts. This review gives an overview and highlights current improvements in our understanding of the organization, regulation, and diversiﬁcation of core and specialized terpenoid metabolic pathways and discusses the prominent therapeutic roles of terpenoids. This review provides an overview and highlights recent literature in our understanding about the biomedical and therapeutic importance of terpenoids, regulation as well as the diversion of core and specialized metabolized terpenoid pathways.
Assessment of Various Laboratory Diagnostic Methods in Diagnosis of Cutaneous Tuberculosis. A Study from A Tertiary Care Hospital of North India
Authors: Khan Shoaib , Nahvi Nahid , Amin Umara , Bashir Yousuf Ul , Zahoor Danish
Published: April 2021

Cutaneous tuberculosis (CTB) is the rarest case of extrapulmonary TB comprising 2% of total cases. It’s often a challenge both clinically and diagnostically. 1) To determine prevalence, age & gender-wise distribution of CTB. 2) To assess various diagnostic, microbiological modalities for the diagnosis of CTB. 76 skin biopsy specimens from suspected CTB lesions were analysed using following methods – Acid-fast Bacilli (AFB) staining (Ziehl-Neelsen method), growth of mycobacteria in culture (Lowenstein-Jensen media), and Gene Xpert MTB/RIF, Histopathological (H&E staining). Of the 76 specimens, 44 were males and 32 were females. The most commonly affected age group was 40–59 years. Infections were least common in 0-19 years age group. AFB was not seen in any of the primary smears. 10 were confirmed as CTB by the recovery of Mycobacterium in solid culture. Of the 10 culture positives, 9 were confirmed as MTB, and 1 was found to be NTM. Staining of 10 culture positive specimens revealed acid fast, beaded rods. Detection of MTB by Gene Xpert gave positive result in 9 cases with all RIF sensitive. All 9 PCR confirmed cases were also culture positive, all 9 were slow growers with a minimum of 5 weeks required for growth on the LJ slant. PCR is the test of choice and should be performed on all specimens of suspected CTB. However when coupled with the “gold standard” culture method, the diagnostic accuracy improves. Also, further, culture helps in identification and isolation of NTM’s.
Expressibility of the alternating layered ansatz for quantum computation
Authors: Nakaji Kouhei , Yamamoto Naoki
Published: April 2021

The hybrid quantum-classical algorithm is actively examined as a technique applicable even to intermediate-scale quantum computers. To execute this algorithm, the hardware efficient ansatz is often used, thanks to its implementability and expressibility; however, this ansatz has a critical issue in its trainability in the sense that it generically suffers from the so-called gradient vanishing problem. This issue can be resolved by limiting the circuit to the class of shallow alternating layered ansatz. However, even though the high trainability of this ansatz is proved, it is still unclear whether it has rich expressibility in state generation. In this paper, with a proper definition of the expressibility found in the literature, we show that the shallow alternating layered ansatz has almost the same level of expressibility as that of hardware efficient ansatz. Hence the expressibility and the trainability can coexist, giving a new designing method for quantum circuits in the intermediate-scale quantum computing era.
Case of Severe Seronegative Autoimmune Rhombencephalitis Successfully Treated with Rituximab
Authors: Zarka Farah , Slaoui Tarik , Makhzoum Jean-Paul
Published: April 2021

ABSTRACTPrompt treatment of autoimmune encephalitis can prevent long-term neurological sequelae. However, the data and evidence for the treatment of autoantibody negative encephalitis are limited, particularly so for rhombencephalitis. We report the case of a seronegative autoimmune rhombencephalitis successfully treated with rituximab.A 21-year-old woman was transferred to our center for progressive neuropsychiatric symptoms and neurological deficits progressing into a Locked-in state despite first-line immunotherapy with corticosteroids and immunoglobulins. She was started on a rituximab induction protocol with noticeable improvement within days. The patient then received a maintenance dose and during a follow-up after 9 months was still in remission, suggesting that rituximab can be an efficient treatment for severe refractory seronegative rhombencephalitis
RÉSUMÉUn traitement rapide de l’encéphalite auto-immune peut prévenir les séquelles neurologiques à long terme. Cependant, les données et les preuves concernant le traitement de l’encéphalite séronégative sont limitées, en particulier pour la rhombencéphalite. Nous faisons état d’un cas de rhombencéphalite auto-immune séronégative traitée avec succès par le rituximab.
Une femme de 21 ans a été transférée dans notre centre pour des symptômes neuropsychiatriques progressifs et des déficits neurologiques progressant vers un état de blocage malgré une immunothérapie de première intention avec des corticostéroïdes et des immunoglobulines. Un protocole d’induction au rituximab a été entrepris et on a constaté une amélioration notable en quelques jours. La patiente a ensuite reçu une dose d’entretien et, après neuf mois de suivi, elle était toujours en rémission, ce qui permet de penser que le rituximab peut s’avérer un traitement efficace pour les rhombencéphalites séronégatives réfractaires graves.
How to Set Up a Perioperative BNP/NTproBNP and Troponin Screening Program
Authors: Sloan Erin N. , Morley Erin E.
Published: April 2021

Key Learning Points1. Review the rationale and evidence to support the use of perioperative biomarkers (BNP/NTproBNP and troponin)2. Explore three unique models for integrating perioperative biomarkers into practice3. Apply guiding principles to perform a site-specific assessment of the current approach to perioperative risk assessment and review strategies on how to initiate implementation of a perioperative biomarker screening program4. Understand commonly faced challenges, and proposed solutions, for implementing a perioperative biomarker screening program5. Appreciate the potential role for a shared-care model to facilitate perioperative biomarkers screening and management
 
Points à retenir1. Examiner la justification et les données probantes à l’appui de l’utilisation de biomarqueurs périopératoires (BNP/NTproBNP et troponine).2. Explorer trois modèles uniques pour l’intégration de biomarqueurs périopératoires dans la pratique.3. Appliquer des principes directeurs pour réaliser une évaluation propre au site de l’approche actuelle en matière d’évaluation des risques périopératoires et examiner les stratégies sur la manière d’entreprendre la mise en œuvre d’un programme de dépistage périopératoire de biomarqueurs.4. Comprendre les défis couramment affrontés et les solutions proposées pour la mise en œuvre d’unprogramme de dépistage périopératoire de biomarqueurs. 5. Prendre la mesure du rôle potentiel d’un modèle departage des soins pour faciliter le dépistage et la prise en charge de biomarqueurs périopératoires.
Perioperative Medicine Special Issue / Numéro spécial sur la médecine périopératoire
Authors: Patel Ameen , Duceppe Emmanuelle , Douketis James
Published: April 2021

Perioperative Medicine Special Issue / Numéro spécial sur la médecine périopératoire
Modelado de Información de Construcción desde un análisis bibliométrico
Authors: Osorio Gómez Cristian Camilo , Foronda Ocampo Fabián Andrés , Amariles López Cristhian Camilo , González García Juan Esteban
Published: April 2021

Bibliometry is responsible for applying mathematical and statistical methods to scientific research; this discipline is responsible for measuring scientific studies by applying quantitative variables to articles or texts produced by a scientific nature. A bibliometric analysis was carried out where the term "BIM" was consulted, which is the acronym for Building Information Modeling. The search was carried out in the scientific research portal Web of Science, obtaining 684 journal articles related to civil engineering and construction technology. Additionally, the bibliometric analysis software (Bibliometrix) was implemented with which analysis of co-occurrence, cocitation, and co-authorship was carried out, which allowed the study carried out to be better visualized in graphic form. The results of the research show growth in Building Information Modeling research in recent years, noting that the countries with the highest contributions are China, the United States, and the United...
Técnicas moleculares empleadas para la detección de babesia spp. en bovinos: revisión sistemática
Authors: Arredondo Botero Julia Victoria , Ríos Marín Joan Mateo , Ospino Sánchez Juan Diego
Published: April 2021

Bovine babesiosis is one of the most important parasitic diseases in the world, it is caused by protozoa of Babesia genus and generates anemia, anorexia, weight loss, jaundice and hemoglobinuria generating loss in production and even the death of the animal. Serological tests are relatively inexpensive and efficient to detect the parasite, but the results depend on factors inherent to the animal and the state of infection. Molecular markers are more precise tools to detect the parasite. The aim of the current systematic review was to review original studies, published between 2010 and 2018, in which molecular techniques were implemented to detect the parasite. The research was carried out using PubMed, LILACS, SciELO and Science Direct databases. 196 records were identified according to the research criteria and only 47 were analyzed. The main molecular techniques reported include Polymerase chain reaction (PCR), nested PCR (nPCR) and semi nested PCR, Real time PCR (qPCR), Reverse ...
La formación en ciencias sociales e historia: el caso de la facultad de ciencias de la educación de la Universidad Tecnológica de Pereira (1970-2017)
Authors: Correa Ramírez Jhon Jaime , Agudelo Castañeda Natalia
Published: April 2021

This article outlines different stages of education in social sciences at the Faculty of Education of the Universidad Tecnológica de Pereira, articulated with the national and international context. We adhere to the conception of Jaime Jaramillo Uribe on the history of education as cultural and political history, to analyze the double perspective of internal history, which accounts for the different relationships between the field of knowledge and disputes of a curricular nature; besides, external history, represented in the contexts of each era in the reforms emanating from the State that generated contradictions in the academic communities, which resulted in ideological conflicts within the university between political sectors, and in the recurring tensions between modernization and autonomy. It is about to analyze historically the relationships between the teacher education at the School of Social Sciences of the UTP and the curricular restructuring that were deciding in the search ...
DEVELOPMENT OF APPLE TISSUE AND ACID TREATED MULTI WALLED CARBON NANOTUBE BASED AMPEROMETRIC BIOSENSOR FOR PHENOL DETECTION
Authors: ÖREN VAROL Tuğba
Published: April 2021

The fabrication of acid functionalized multi-walled carbon nanotube (fMWCNT) combined apple tissue based amperometric biosensor through a cross-linking agent-free approach has been presented for the phenol detection in this study. Apple tissue entrapped in fMWCNT-glassy carbon paste composite was employed as the natural polyphenol oxidase source for the enzymatic oxidation of phenol and the consumption of the dissolved oxygen was monitored via chronoamperometry as the biosensor response. The effect of experimental parameters (e.g. working potential, pH and tissue amount) were examined to obtain the optimum measurement conditions. Under optimized conditions, amperometric responses linearly increased in the range of 10-200 µM phenol and limit of detection was calculated as 3.26 µM (n=3). Apple tissue based biosensor was utilized for the phenol detection in tap water samples by serving satisfying recovery values.
PREVALENCE, RISK ASSESSMENT, AND PREDICTORS OF OSTEOPOROSIS AMONG CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS.
Authors: Bitar Ahmad Naoras , Khan Amer Hayat , Sulaiman Syed Azhar Syed , Ali Irfhan Ali Bin Hyder
Published: April 2021

The link between COPD and osteoporosis is unclear and yet to be
understood. This study aimed at detecting the prevalence and investigate
the predictors for low bone mineral density among COPD patients and
tested a new risk assessment tool for the early screening of
osteoporosis among COPD patients.

This study is a longitudinal observational study conducted from
June-2019 until December-2020 at a tertiary care setting in Penang,
Malaysia. Follow-ups were arranged every six months. During the
study, patients’ BMD was checked every visit, and the subjects’
pulmonary parameters were recorded, including; mMRC dyspnea scores, CAT
scores, spirometry results, exacerbations history, and
SpO%. Furthermore, a novel risk assessment tool was
validated in this study, and logistic regression was conducted to find
low BMD predictors among COPD patients.

Based on T-score, more than 50% of subjects were osteoporotic based.
The overall mean±SD for patients’ age was 65.4±10.04. The overall
mean±SD for patients’ BMI was 23.32±5.43. Both FEV1% predicted, and
FEV/FVC was significantly lower among osteoporotic subjects, and lower
mMRC stages were observed among non-osteoporotic patients. For the novel
risk assessment tool, a cutoff point of 34 made the optimum balance
between sensitivity and specificity (0.867 and 0.087, respectively) with
an AUC of 0.934. Furthermore, severe COPD patients were four times at
higher risk of getting osteoporosis, FEV% predicted, and FEV/FVC was
inversely related to the risk of osteoporosis. Patients with severe
dyspnea had twice the risk of getting osteoporosis.

Osteoporosis was prevalent among COPD patients. For a screening tool,
the risk assessment tool showed good sensitivity and precision in
detecting osteoporotic subjects among COPD patients. Severe COPD
patients were significantly at higher risk of getting osteoporosis.
Delay differential equations for the spatially-resolved simulation of epidemics with specific application to COVID-19
Authors: Guglielmi Nicola , Iacomini Elisa , Viguerie Alexander
Published: April 2021

In the wake of the 2020 COVID-19 epidemic, much work has been performed
on the development of mathematical models for the simulation of the
epidemic, and of disease models generally. Most works follow the
susceptible-infected-removed (SIR) compartmental framework, modeling the
epidemic with a system of ordinary differential equations. Alternative
formulations using a partial differential equation (PDE) to incorporate
both spatial and temporal resolution have also been introduced, with
their numerical results showing potentially powerful descriptive and
predictive capacity. In the present work, we introduce a new variation
to such models by using delay differential equations (DDEs). The
dynamics of many infectious diseases, including COVID-19, exhibit delays
due to incubation periods and related phenomena. Accordingly, DDE models
allow for a natural representation of the problem dynamics, in addition
to offering advantages in terms of computational time and modeling, as
they eliminate the need for additional, difficult-to-estimate,
compartments (such as exposed individuals) to incorporate time delays.
In the present work, we introduce a DDE epidemic model in both an
ordinary- and partial differential equation framework. We present a
series of mathematical results assessing the stability of the
formulation. We then perform several numerical experiments, validating
both the mathematical results and establishing model’s ability to
reproduce measured data on realistic problems.
Unravelling the plant diversity of the Amazonian canga through DNA barcoding
Authors: Vasconcelos Santelmo , Nunes Gisele , Dias Mariana , Lorena Jamily , Oliveira Renato , Lima Talvâne , Pires Eder , Valadares Rafael , Alves Ronnie , Watanabe Maurício , Zappi Daniela , Hiura Alice , Pastore Mayara , Vasconcelos Liziane , Mota Nara , Viana Pedro , Gil André , Simões Andre , Imperatriz-Fonseca Vera , Harley Raymond , Giulietti Ana , Oliveira Guilherme
Published: April 2021

The canga of the Serra dos Carajás, in Eastern Amazon, is home to a
unique open plant community, harbouring several endemic and rare
species. Although a complete flora survey has been recently published,
scarce to no genetic information is available for most plant species of
the ironstone outcrops of the Serra dos Carajás. In this scenario, DNA
barcoding appears as a fast and effective approach to assess the genetic
diversity of the Serra dos Carajás flora, considering the growing need
for robust biodiversity conservation planning in such an area with
industrial mining activities. Thus, after testing eight different DNA
barcode markers (matK, rbcL, rpoB, rpoC1, atpF-atpH, psbK-psbI,
trnH-psbA and ITS2), we chose rbcL and ITS2 as the most suitable markers
for a broad application in the regional flora. Here we describe DNA
barcodes for 1,130 specimens of 538 species, 323 genera and 115 families
of vascular plants, with a total of 344 species being barcoded for the
first time. In addition, we assessed the potential of using DNA
metabarcoding of bulk samples for surveying plant diversity in the
canga. Upon achieving the first comprehensive DNA barcoding effort
directed to a complete flora in the Brazilian Amazon, we discuss the
relevance of our results to guide future conservation measures in the
Serra dos Carajás.
Dengue virus type 2 replication is limited by activation of NOD2 and its interactions with RIP2 and MAVS adaptors in THP-1 macrophage-like cells
Authors: Domínguez-Martínez Diana , Avellaneda Daniel Nuñez , Cruz Juan Castillo , León-Avila Gloria , GARCIA-PEREZ BLANCA , Salazar Ma. Isabel
Published: April 2021

The nucleotide-binding domain (NBD) and leucine-rich repeat receptors,
such as NOD-like receptors (NLRs), have pivotal functions in the innate
immune response to various viral infections participating during the
recognition of pathogens and activation of signaling pathways. One NLR,
NOD2, is a dynamic protein that is activated in the presence of viral
genomes and metabolites. However, its participation in combating a
dengue virus (DENV) infection remains unclear. The aim of this study was
to determine the role of NOD2 in macrophage-like THP-1 cells during an
in vitro infection with DENV type 2 (DENV2). The interactions of NOD2
with RIP2 and MAVS was examined in DENV2-infected and agonist-stimulated
cells. The effects of downregulating NOD2 expression or signaling on
virus loads was also evaluated. The cellular mRNA expression and protein
levels of NOD2 on cells under the stimuli were quantified with RT-PCR,
Western blot and indirect immunofluorescence. Both the mRNA and protein
expression of NOD2 was enhanced in response to DENV-2 infection.
Interactions of NOD2 with RIP2 and MAVS, analyzed with confocal
microscopy and co-immunoprecipitation assays, were time-dependent and
increased in the post-infection period, between 6 and 24 h. After
silencing NOD2 expression, DENV2-infected cells displayed greater viral
loads and decreased expression of IL-8 and IFN-α (measured in
supernatants obtained from the cells), compared to the uninfected (mock
control) cells or those transfected with irrelevant-siRNA. Thus, in
response to a DENV2 infection, NOD2 was activated in THP-1 human
macrophage-like cells, the production of IL-8 and IFN-α was enhanced,
and viral replication was limited.