bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanotheranostics: A powerful next-generation solution to tackle the chronic disease
Authors: Gandhi M. , Boghara M.
Published: March 2024

The use of nanotheranostics is the most advanced diagnostic and therapeutic techniques for a variety of disorders like cancer, IDs, HIV has drawn significant interest in the last ten years. Currently, various methods are use in the development of bright nanotheranostics, which mix bioactive concentrating on particular tissues and diagnostic capabilities. By using nanotheranostics, keeping track the therapy responses in real-time and therapeutic drugs is delivered. As a result, there is less chance of consuming too much medication. Several non-intrusive Imaging methods have been applied to track the medication distribution processes quantitatively. Radiolabeling of nanoparticles is a popular and effective method of nuclear diagnostics imaging in medicine. Numerous nanoparticles really have been created and they have effective qualities, they were created for imaging tumors and other lesions because of their effective qualities. Multifunctional nanotheranostics have been described for inorganic nanoparticles like gold, silver, silica-based nanomaterials, or organic nanoparticles including polymers, carbon-based nanomaterials, and liposomes. A summary of the most recent nanotheranostics organized according to the utilized nanomaterials is provided. Finally, as material scientists who work in the field of nanotheranostics can use this review as a guide to create newer and more effective nanotheranostics, it can be advantageous to the medical and pharmaceutical communities as well as of society.
Decoding marfanoid syndrome: Breakthroughs in genetic understanding
Authors: Prajapati Bhupendra G. , Shah Nidhi N. , Chorawala Mehul R.
Published: March 2024

Marfanoid Syndrome (MFS), a rare and complex genetic disorder, has long eluded a complete understanding of its intricate web of manifestations and underlying genetic factors. This review navigates the recent landscape of genetic research, offering an in-depth exploration of breakthroughs that have reshaped our comprehension of MFS. Focusing on pivotal genetic markers such as FBN1, TGFBR1, and TGFBR2, it unveils the specific mutations integral to the syndrome's clinical tapestry. Advancements in genomic technologies, notably next-generation sequencing and CRISPR-Cas9 gene editing, have propelled the field forward, accelerating the identification and analysis of genetic mutations with unprecedented precision. The review sheds light on how these technological strides have not only uncovered new genetic markers but also illuminated the intricate interplay of genes influencing the pathogenesis of MFS. Precision medicine takes center stage in the therapeutic frontiers, as understanding specific genetic mutations enables tailored interventions. This review provides a holistic perspective, encompassing genetic landscapes, technological revolutions, and emerging therapeutic paradigms, aiming to contribute to the ongoing discourse, foster a proactive approach to patient care, and inspire further research in the dynamic realm of MFS.
Protective role of hydroxy citric acid (HCA) against lead induced toxicity in albino wistar rats
Authors: Sivaji K , Nandyala Srinivas , SS Prasanna Kumar P , Anjali T
Published: March 2024

The present study was designed to evaluate the role of herbal active constituent hydroxycitric acid obtained from Garcinia cambogia and Hibiscus subdariffa in heavy metal especially lead poisoning. The Lead acetate at 500ppm was used as an inducing agent in the present study. Sodium acetate (500ppm) used as control group is used as a baseline measure. The HCA at 100 mg/kg and 200mg/kg were used in the treatment of lead induced toxicity in rats. At the end of 28 days study period the blood levels of alpha ALAD activity was estimated in all the treatment groups. Lead inhibits the ALAD is more profound and its inhibition has been used clinically to gauge the degree of lead poisoning. Inhibition of ALAD results in the accumulation of aminolaevulinic acid, detectable in the plasma and urine even at blood lead levels of less than 10 µg/dl. It results that HCA showed significant elevated levels of ALAD activity, which was reduced by the lead intoxication. HCA showed significant reduction of liver enzymes (SGOT, SGPT and ALP). The markers like protein, bilirubin and creatinine were also found to be elevated in lead intoxicated rats and was found to be decreased significantly in a concentration dependent manner.
Design, Implementation and Evaluation of a Training Workshop on Mindfulness in Clinical Encounters for Nursing Students of the Shahid Beheshti University of Medical Sciences
Authors: Z Khoshgoftar , SN Mousavizadeh , H Asadi-Samani , A Hakimzadeh
Published: March 2024

Abstract
Introduction: With the emergence of new and re-emerging diseases and their medical staff and students facing infectious diseases, it was felt necessary to support them regarding the stress and anxiety caused by the disease. Therefore, this study was conducted to design, implement, and evaluate a workshop on mindfulness in clinical encounters for nursing students.
Method: This educational research was conducted on 66 nursing students based on the Glasik criteria. First, the needs and goals were determined based on the literature review and expert panel; the workshop was designed with a focused group of student representatives, and then the implementation of the program began. For evaluation, the satisfaction form was used to measure learning, anxiety, and performance.
Results: The average satisfaction of the learners with the efficiency of the course was 32.3 and the satisfaction with the organization of the course was 25.6. The average work participation before the workshop was 19.33 ± 6.19, which after the workshop was 28.13 ± 4.69 and was significant (P < 0.001). The average anxiety before the workshop was 20.40 ± 10.73, but after the workshop decreased to 10.90 ± 13.64 and was significant (P < 0.001). The mean of mindfulness before the workshop was 89.46 ± 17.16, which reached 99.26 ± 18.70 after the workshop (P = 0.007).
Conclusion: The mindfulness workshop provides a suitable opportunity to practice techniques for dealing with stress and critical situations for undergraduate students who have fewer skills. It is suggested to investigate this intervention at other educational levels.
E-learning Quality Assessment Indicators: A Narrative Review
Authors: F Sadeghi , S Fazaeli , KH Kimiafar , F Ameri , M Meraji
Published: March 2024

Introduction: Due to the widespread use of this educational method in the universities of the world and Iran, there is a need to evaluate its quality using indicators and approaches. Therefore, the present study was conducted to evaluate the quality evaluation indicators of electronic education.
Method: The present study was conducted according to the guidelines of PRISMA. For this purpose, Web of Science, PubMed, Scopus, Mogiran, Irandak and SID databases were searched in the period from 2018 to 2022. The search strategy included the concepts of "e-learning", "index" and "medical science students". The criteria for entering this study were original articles in Persian and English. After selecting the studies, data collection was done based on the data extraction form.
Results: A total of 77 articles were included in this review. From the review of studies, 37 indicators in 6 categories of factors related to students (5 indicators), factors related to professors (11 indicators), factors related to educational content (5 indicators), factors related to required facilities (7 indicators), factors related to Management (5 indicators) and factors related to laws and regulations (4 indicators) were obtained.
Conclusion: The results showed that six factors are involved in evaluating the quality of e-learning. Therefore, it is recommended that the managers of the educational systems to ensure the provision of high-quality training by identifying the weaknesses of the electronic learning software system and laying the foundation for their elimination.
Using the Peer Learning Method in the E-learning Process: Creating a Support-Motivational Mechanism for the Parasitology MS Students in Shahid Sadougi University of Medical Sciences, Yazd
Authors: AA Jafari , G Eslamii , A Fattahi-Bafghi , M Golamrezaei , F Mirzaei , M Azizy , M Gholami
Published: March 2024

Introduction: Specialized training is the most crucial turning point of education in obtaining the professions related to medical sciences. Peer learning has advantages, including saving time and eliminating the limitations of traditional education. The purpose of current educational program during the COVID19 pandemic was to reduce students’ stress and more accepted in the parasitology PhD exam.
Method: Faculty members and MsC Students in the Department of Medical Parasitology, Yazd medical university, performed the present developmental study based on the reference books and curriculum. First, a training virtual platform was designe using a topic, picture, video of a parasite or parasitic diseases between the learners under the supervision of all the scientific members. Learners designed questions and their answers for each title in the virtual platform. In the end, to help the students to participate in the PhD exam, two virtual pre-exams were also designed. Finally, the satisfaction level of faculty members and students, as wll as their stress level's was evaluate using Excel software.
Results: Of 25 student participants, six succeeded in the first stage and finally, three of them were accepted in the second stage of the parasitology Ph.D. exam in the 2021-2022 academic years. Implementation of this peer learning method was also effective in reducing the stress level of students in the Ph.D. exam.
Conclusion: Considering the success of the peer learning program using virtual learning in current study and more passing in the Ph.D. exam, it suggests that this plan will be implemented in other educational groups with postgraduate education.
The Impact of Data-Driven Learning on Medical Students' English Academic Writing
Authors: A Dehghan , AM Fazilatfar , AK Jabbari
Published: March 2024

Introduction: Data-driven learning has emerged as a powerful method in language teaching and has drastically changed the traditional methods of teaching and learning, especially in academic writing. So, the present study was conducted to investigate the effect of data-driven learning on the English academic writing of medical students.
Method: In this quasi-experimental intervention study, 29 MSc students of different fields of medical sciences participated in a training intervention program using a data-driven learning approach focusing on self-generated corpora of academic articles related to their fields of study. Students were asked to write an academic text related to their fields at the beginning and end of the course. Written texts were graded based on the Hemp-Lyons academic writing rubric, and the data collected from the pre-and post-test assessments were analyzed using the paired-sample t-test.
Results: Comparison of pre-test scores with a mean of 59 (SD = 2.26) and post-test scores with a mean of 78.53 (SD = 2.33) indicated a significant improvement in the writing of the participants of this study (p < 0.05).
Conclusion: In light of confirming the educational suitability of the data-driven approach and recognizing the need for students to engage in English article writing and publication, these findings serve as a valuable aid to MSc students studying medical sciences, facilitating their academic writing in English.
Donors’ Participation the Health System: A Double-Edged Sword
Authors: Khanjankhani Khatere , Najibi Seyede Maryam
Published: March 2024

The presence of donors in health system, despite its positive results, can also have weaknesses that sometimes act as a double-edged sword in achieving health priorities. In some cases, the needs are considered by donors as unnecessarily the real ones in health system. On the other hand; sometimes, benevolent actions are involved in political intentions and pressures.
In order to eliminate deficiencies, it is necessary to comply with standards, priorities, and real needs of health system in any field. What helps this alignment and action towards goals is using the capacity of scientific evidence. With the help of scientific evidence, the real needs of health sector can be identified and prioritized, and the capacity of donors can be used to meet those needs. Moreover, reforming and re-engineering the processes of benefactors' activities in the field of health, directing benefactors' aid, developing rules and standards, and creating transparency in costs for inter-sectoral coordination are solutions that will help to improve the conditions about this issue.
Estimating the Number of Department Secretaries Needed in in Hazrat Zainab Hospital Based on Workload Indicator of Staffing Needs in 2023
Authors: Bakhtiary Nahid , Bahrami Mohamad Amin , Bastani Peivand
Published: March 2024

Background: Department secretary position is one of the most important and practical jobs in the hospital, which is often neglected. The secretary of the nursing department is responsible for carrying out all office affairs of the department under the direct supervision of the supervisor; Therefore, proper planning for adequate supply of these forces in hospital departments is very important.
Results: According to the results of the research, at the time of the study in Hazrat Zainab (S) Shiraz Hospital, 13 secretaries were working, and the required number of secretaries in the department was 12.94 based on the WISN; but, since a work measurement was done for each department separately, the result was different in each department.
Conclusion: Results revealed that, in general, there is no shortage of secretaries in hospital departments, and there is no need to recruit new staff; however, in terms of workload, there is no balance between different departments, so it is necessary to balance the workload in different departments through proper planning.
Pathology of the Research Sector in Iran's Health System with a Focus on Future
Authors: Haghdoost AliAkbar , Dehnavieh Reza , Poursheikhali Atousa , Golkar Mostafa Hosseini , Masoud Ali
Published: March 2024

Background:  Strengthening the functions of health research and taking a systematic approach to the development of science and technology are essential for overcoming current challenges in health sector. Therefore, the functional pathology of current research plays a crucial role in highlighting the gap between what is and what should be, thereby illuminating the path of scientific development in health sector with a focus on current challenges.
Methods: This study utilized qualitative exploratory approaches, regarding interviews with experts and expert panel formation, to complement the authors' experiences in the field of research. In this process, relevant national upstream documents, experiences from other countries, and reviews of other documents were used to reinforce and analyze the findings. To adopt a future-oriented approach, the Future Triangle framework was employed to depict the tension between future images, the weight of past experiences, and the pressure of the current time.
Results: The research functions were categorized into seven groups: leadership and guidance, research coordination and policy-making, translating upstream documents policies into operational programs, resource management, performance evaluation and monitoring, empowering the workforce and policy-making based on evidence and pathology. Under each category, strategies for moving away from the current situation were provided.
Conclusion: The main solutions to address the current challenges in the country's health research system include agreement on concepts, a unified vision and stable procedures, strengthening the relationship between different levels of management (inter-ministerial, ministerial, and university), enhancing education and research at the level of medical ministry and universities, establishing appropriate structures for knowledge translation, strengthening national funds supporting the research, reforming the evaluation system, and undertaking a fundamental review of human resource empowerment model.
Comparison of Rapid Antibiotic Susceptibility Test Method Directly from Blood Culture Bottle with Standard Disc Diffusion Method
Authors: Keskin Banu Hümeyra , Öksüz Şükrü
Published: March 2024

Aim: Early determination of antimicrobial susceptibility of sepsis pathogens is important. In this study, we aimed to compare the standard disc diffusion method with the rapid antimicrobial susceptibility testing (RAST) method performed directly from blood culture bottles.
Material and Methods: Bacteria isolated from samples that gave a positive signal on the blood culture device between April 2019 and September 2019 were included in the study, and antimicrobial susceptibilities were determined by the standard disc diffusion method and the RAST method. Categorical agreement, small error, large error, very large error, and area of technical uncertainty ratios were recorded.
Results: A total of 103 bacteria including 19 S. aureus, 10 Enterococcus spp. and 24 E. coli, 24 K. pneumoniae, 13 P. aeruginosa, and 13 A. baumannii were included in the study. When the RAST method was compared with the standard disc diffusion method, 100% agreement was found between the methods against imipenem, meropenem, gentamicin, and trimethoprim-sulfamethoxazole in E. coli isolates at all hours evaluated, and against meropenem in K. pneumoniae isolates at the 6th and 8th hour. For S. aureus and P. aeruginosa isolates, very major errors were found in the RAST results. For A. baumannii isolates, 100% agreement between methods was observed for many antibiotics.
Conclusion: It was concluded that the RAST method is a simple and inexpensive test for life-threatening infections such as sepsis. It was also felt that similar studies should be carried out with a large number of isolates, as compliance rates vary depending on the bacteria tested.
A Percepção dos Jovens sobre o Teletrabalho durante a Pandemia da Covid-19
Authors: Do Nascimento Gonçalves Mayara , Vasconcellos Liliana , Da Conceição Santos Silva Humberta Karinne
Published: March 2024

No Brasil e no mundo, a pandemia decretada em março de 2020, compeliu as organizações a adotarem a modalidade teleworking ou teletrabalho, como maneira de se manterem ativas e competitivas frente ao novo cenário socioeconômico. Há inúmeros estudos que discutem os benefícios e desafios da prática do para organizações e para trabalhadores. No entanto, diante desse fenômeno inédito, pandemia acompanhada de medidas de distanciamento social ampliado, poucos são os estudos que trazem a perspectiva qualitativa e subjetiva do trabalhador. Por isso, este trabalho visa conhecer a percepção de jovens trabalhadores sobre o teletrabalho realizado de maneira integral durante a pandemia da Covid-19. Com uma abordagem qualitativa, foram realizadas 13 entrevistas em profundidade com jovens trabalhadores do estado de São Paulo, que, em média, trabalharam 3 meses confinados em suas casas. Os dados foram tratados com análise de conteúdo, através da criação de categorias após a leitura completa do conteúdo das entrevistas (data-driven). Alinhado com a teoria sobre o teletrabalho, a óptica do trabalhador, traz aspectos relacionados ao ambiente laboral, como os recursos e relacionamentos interpessoais, e também sobre a vida pessoal, familiar e social como uma prerrogativas. Para estudos futuros, recomenda-se abranger um maior número de teletrabalhadores e comparar os resultados após o período pandêmico, de modo a conhecer o processo de transição.
Cytological, Histopathological and Immunohistochemical Studies on Naturally Occurring Cutaneous Melanomas in Cattle in and Around Namakkal, Tamil Nadu, India
Authors: Nithya P. , Balasubramaniam G.A. , Arulmozhi A. , Gopalakrishnamurthy T.R. , Kathirvel S.
Published: March 2024

Background: Melanomas are tumours that originate from melanoblasts. The studies on bovine tumours are of clinical concern since some melanocytic tumours are congenital and occur in young animals. The present work was carried out to study the pathomorphological characteristics of melanomas in cattle for early diagnosis and intervention. Methods: Tumour samples were collected from suspected cases of neoplasia from four animals during the study period. Data pertaining to the animals were collected. Fine needle aspiration cytology and impression smear were stained with Giemsa stain. Tissue samples were collected in 10 per cent neutral buffered formalin for histopathological examination. Special staining with Fontana silver stain and immunohistochemistry with Melan- A and S- 100 markers for confirmatory diagnosis of melanin pigment was done. Result: Cytology revealed neoplastic cells with vacuolation and pleomorphism. Cytoplasm contained abundant melanin pigments. Microscopically, the cytoplasm contained abundant brown, black coloured melanin pigment granules. Tissue sections stained with Fontana silver impregnation method revealed the presence of black coloured granules. Immunohistochemistry with Melan-A and S-100 revealed strong expression of brown coloured reaction in the cytoplasm of the neoplastic cells.
Probiotic Potential of Autochthonous Lactobacillus against Avian Pathogenic Escherichia coli
Authors: Pooja M. , Srivani M. , Ramanipushpa R.N. , Aswanikumar K. , Srilakshmi J.
Published: March 2024

Background: The aim of current study was to investigate the probiotic potential of autochthonous Lactobacillus species against pathogenic Escherichia coli in poultry. Method: A total of 73 samples were collected from cloacal swabs and tissues of desi and commercial chicken. The Lactobacillus were isolated based on cultural, biochemical and molecular teats. The probiotic potency was tested in vitro and antimicrobial activity and ABST was carried by Agar well diffusion and disc diffusion methods, respectively. Nucleotide sequencing was done by Sanger sequencing. Haemolysis and gelatin hydrolysis assays were used as safety testes. Result: From 73 cloacal swabs and tissues of desi and commercial chicken, 56 Lactobacillus were isolated of which 22 showed high autoaggregation and hydrophobicity potential. Based on survivability at acidic pH (2.5) and bile concentrations (0.5%), 16 isolates were selected and were subjected to well diffusion assay against pathogenic E. coli. All the isolates showed zone of inhibition against E. coli ranging from 10 -18 mm. ABST revealed that all the isolates are sensitive to chloramphenicol, ampicillin and erythromycin and 75% of the isolates were resistant to streptomycin, gentamicin and vancomycin. Only one isolate out of 16 tested was non hemolytic and none of the isolates tested positive for gelatine hydrolysis. Sequencing result of selected isolate revealed 96.82% of its similarity to Lactobacillus fermentum.
Variation in Physiological Traits of Blackgram (Vigna mungo L.) Genotypes under High Temperature Stress
Authors: Pavithra N. , Jayalalitha K. , Sujatha T. , Harisatyanarayana N. , Lakshmi N. Jyothi , Roja V.
Published: March 2024

Background: Blackgram is one of the important short duration pulse crop which is sensitive to high temperatures. The rising global temperatures are threatening the yield of blackgram by altering the physiological processes at cellular level. Keeping this in view, the present investigation was carried out for better understanding of genotypic variability and the physiological mechanisms governing heat stress tolerance which can help in identifying heat tolerant blackgram genotypes that can yield better under climate change scenarios. Methods: Thirty blackgram genotypes selected from temperature induction response technique were evaluated for physiological efficiency under natural high temperature conditions during summer, 2022 and 2023. Field experiment was conducted at Agricultural College Farm, Acharya N.G Ranga Agricultural University, Agricultural College, Bapatla. Physiological and yield parameters were recorded at flowering and the data were analyzed statistically and pooled. Result: Significant genetic variability was observed among the blackgram genotypes with respect to all the physiological traits under high temperature stress conditions. Among the 30 genotypes tested for thermotolerance, the genotypes TBG-129, PU-1804, LBG-1015, PU-31 and TBG-104 were found to withstand high temperature stress at reproductive stage by maintaining higher total chlorophyll, carotenoids, chlorophyll stability index, total biomass production, cooler canopies resulting into higher canopy temperature depression, less membrane injury index values and higher yield. Correlation analysis revealed a strong positive correlation for all the physiological traits with seed yield except membrane injury index under heat stress conditions. The PCA results revealed considerable variability among the traits accounting for 82.65% of total variability. The genotypes TBG-129, PU-1804, LBG-1015 and TBG-104 can be potentially used as donors in the breeding programmes for the development of heat tolerant genotypes.
The lake’s image in the artistic worldview of the Northern text of Russian literature for children
Authors: Davydova A. V.
Published: March 2024

INTRODUCTION. For the first time, the works of the Northern Text of Russian literature for children, in which the lake’s image arises, are systematized. The purpose of the study is to consider the artistic and semantic features of the leitmotif image of the lake in the context of the specifics of the artistic world of the North. The objectives of the research are to identify the main mythopoetic and realistic characteristics of the lake’s image in the works of the Northern text for children; to determine the motives and images with which it interacts as a structural element of the Northern text, to identify the place of the lake’s image in the artistic worldview of the North.

MATERIALS AND METHODS. Using a systematic approach to the literary text, which is a set of methods (chronotopic, motivic, mythopoetic, systemic-semantic) that reveal the object as a single system, the lake’s image in the works of writers of the second half of the 20th century is considered: A. Linevsky, A. Petukhov, V. Pikul, M. Skorokhodov, A. Chlenov.

RESULTS AND DISCUSSION. After analyzing the artistic material, it is concluded that there are two variants of the lake ’s image: tundra and forest lakes. The first is realized through the mythologeme of the circle and the personification method, the second through the motives of the two worlds, secrets, boundaries, changes of the hero. The lake’s image in the Northern text of Russian literature for children also approaches the images of the sea and the river and actualizes the motif of the unity of the world.

CONCLUSION. This study is a particular stage in the study of the figurative-semantic structure of the Northern text of Russian literature for children as a supertext and indicates broad prospects for its further study.
Semantic differentiation in the linguistic examination of trademarks
Authors: Novichihina M. E.
Published: March 2024

INTRODUCTION. The controversial issues of trademark examination are considered. The analysis of the ways of comparing single-word and compound commercial designations is given. A universal method for identifying a strong element in a composite designation has not yet been developed. The purpose of the study is to identify the semantic potential of non-identical concepts: a strong element and the main word in the phrase of a trademark or commercial designation.

MATERIALS AND METHODS. Using a specific example from the experience of conducting linguistic examinations (comparison of the WHITE AURORA and AVRORA designations), the methodology for identifying a strong element of a composite designation is illustrated and the origins of typical errors in determining a strong element are analyzed. When developing the mentioned methodology, it is proposed to be guided by the following considerations: the concept of a strong element of designation and the main word of the corresponding phrase are concepts that are not common; the method of identifying a strong element in a phrase differs from the method of identifying the main word in a phrase; the phenomenon of a strong element correlates with the linguistic idea of a strong and weak lexical position in the text; a strong element can be located both in the first and second place in a phrase, including a trademark or other commercial designation.

RESULTS AND DISCUSSION. It is shown that due to the semantic potential of a strong element of a composite designation, it becomes possible to transfer to the consumer the necessary information about the object of nomination. That is why the definition of an element bearing the main disti nguishing features must be carried out in the context of a situation or a communicative task. Based on the material of a specific example of linguistic expertise, it is shown that the element white of the designation WHITE AURORA in the context of the provision of dental services and dental care services can be interpreted as a strong element. This becomes a serious factor preventing the appearance of confusingly similar designations for WHITE AURORA on the one hand, and AVRORA on the other.

CONCLUSION. Semantic differentiation is the main criterion for distinguishing strong and weak elements in the linguistic examination of trademarks. The very concept of a “strong element” of a designation can be considered a relative concept; the definition of an element bearing the main semantic features must be carried out in the context of a situation or a communicative task.
Promotion through sports: storytelling in telegram channels with sports focus
Authors: Prokhorov A. V. , Popov S. A.
Published: March 2024

INTRODUCTION. In recent decade sport has been viewed as an independent industry. This circumstance contributes to the development of sports marketing concept. In a broad sense, sports marketing covers three main areas: “sports marketing” (sports products promotion activities), “marketing through sports” (marketing of non-sports brands) and “mass sports marketing” (pro-

motion of healthy lifestyle ideas, physical activity). The article examines storytelling technology in the context of promoting goods and services in telegram channels with a sports focus. MATE-

RIALS AND METHODS. The empirical basis of the research is formed by telegram channels of authoritative sports journalists S. Mikulik, V. Utkin, S. Gridasov (“Sergey Mikulik. While in memory ...”, “Real Radio Utkin”, “Gridasov with a beard”). The use of the content analysis method made it possible to identify authors’ types in analyzed telegram channels, as well as to characterize the features of storytelling use in the “packaging” of advertising integrations.

RESULTS AND DISCUSSION. The conducted research allowed us to come to the following results: a) telegram channels with a sports focus have high potential in the “brand-audience” interaction; b) the main format for maintaining telegram channels is storytelling; c) storytelling is an effective way to “package” advertising integrations; d) the tone of storytelling is determined by the type of author of the telegram channel.

CONCLUSION. Storytelling acts as a way to package advertising integrations, helps them achieve a native character, provides “channel tone” necessary for its author, and allows to form author’s style of a channel, which is manifested in the broadcast of the author’s types.
Newsjacking technology in advertising: the topic of sanctions and import substitution
Authors: Terskikh M. V.
Published: March 2024

INTRODUCTION. Newsjacking is a fairly new media technology, which allows you to draw more attention to the promoted product and to ensure standing out from the competitors. Situational marketing of this type presupposes a focus of attention towards the newsworthy events and a high reaction rate to them. In the classic form, a newsworthy event rarely lives longer than five days, but there are also options for a prolonged newsworthy event, the appeal to which can be quite lengthy. COVID-19 became such a relevant “news stream” in 2020, and the topic of sanctions and import substitution in the period 2014–2016, 2022–2023 which is the subject of this study. The purpose of this study is to consider import substitution as the dominant of media discourse, which has become an urgent news reason and the basis of newsjacking technology.

MATERIALS AND METHODS. The material for the study was more than 80 polycode advertising texts, which are based on an appeal to the discursive dominant “import substitution”. To achieve this goal, the following set of methods was used: directional sampling method; descriptive and analytical method; content analysis; discourse analysis; method of systematization and classification.

RESULTS AND DISCUSSION. Analysis of representing the discursive dominant of “import substitution” in advertising texts allowed us to identifies the following basic techniques: use of stereotypical images associated with Russia; use of the symbols of the USSR; turn to the sanctions theme; direct replacement of foreign counterparts with Russian goods; adaptation of foreign brands.

CONCLUSION. The use of the topic of import substitution in advertising is a very significant trend that many advertisers have used for a certain time, and in 2022–2023 this trend was updated in an updated version.
The book collection of A.N. Nortsov: the history of formation, thematic coverage and significance for the creative laboratory of the owner
Authors: Zhitin R. M. , Topilsky A. G.
Published: March 2024

INTRODUCTION. The book heritage of the region’s personal libraries analysis allows us to understand the reading interests’ specifics of different generations of library owners, and to clarify important aspects of the intellectual and spiritual growth of Tambov bibliophiles in the process of working with books. In this regard, the stages of Alexey Nikolaevich Nortsov’s biography are considered in the context of its influence on bibliophilism.

MATERIALS AND METHODS. The fundamental methodology in the work is the principles of objectivity and historicism. The historicism principle made it possible to analyze the book collection of A.N. Nortsov in close connection with the specifics of the epoch and the reader’s needs of the bibliophile. The objectivity principle is i mplemented on the basis of a detailed analysis of historical sources, which makes it possible to comprehensively study the process of completing the Norts library.

RESULTS AND DISCUSSION. A passion for genealogy and history of his native land inevitably left a mark on A.N. Nortsov’s library collection. His personal collection included voluminous collections of books on local history, regional archeology, and genealogy.

CONCLUSION. The study of A.N. Nortsov’s personal library complements the cultural and educational portrait of its owner. The extensive thematic repertoire of the presented books allows us to speak about the broad reading interests of Alexey Nikolaevich, his high artistic taste. At the same time, the library collection acted as a creative laboratory for writing numerous works on the history of the Tambov Region, philosophical, religious, socio-political works.
Chimeric Antigen Receptor (CAR)-T Cell Therapy for Non-Hodgkin’s Lymphoma
Authors: Giraudo Maria , Jackson Zachary , Das Indrani , Abiona Olubukola , Wald David
Published: March 2024

This review focuses on the use of chimeric antigen receptor (CAR)-T cell therapy to treat non-Hodgkin’s lymphoma (NHL), a classification of heterogeneous malignant neoplasms of the lymphoid tissue. Despite various conventional and multidrug chemotherapies, the poor prognosis for NHL patients remains and has prompted the utilization of groundbreaking personalized therapies such as CAR-T cells. CAR-T cells are T cells engineered to express a CAR that enables T cells to specifically lyse tumor cells with extracellular expression of a tumor antigen of choice. A CAR is composed of an extracellular antibody fragment or target protein binding domain that is conjugated to activating intracellular signaling motifs common to T cells. In general, CAR-T cell therapies for NHL are designed to recognize cellular markers ubiquitously expressed on B cells such as CD19+, CD20+, and CD22+. Clinical trials using CAR-T cells such as ZUMA-7 and TRANSFORM demonstrated promising results compared to standard of care and ultimately led to FDA approval for the treatment of relapsed/refractory NHL. Despite the success of CAR-T therapy for NHL, challenges include adverse side effects as well as extrinsic and intrinsic mechanisms of tumor resistance that lead to suboptimal outcomes. Overall, CAR-T cell therapies have improved clinical outcomes in NHL patients and generated optimism around their future applications.
Gambaran Angka Kuman Total pada Handle Pintu Gedung Kampus A Poltekkes Kemenkes Kaltim
Authors: Fitri Nur Eka , Azhari Azhari , Anggrieni Nurul
Published: March 2024

Handle pintu menjadi salah satu media yang sering digunakan sehingga menjadi tempat terjadinya transmisi kuman yang dapat menyebabkan penularan berbagai macam penyakit seperti infeksi nosokomial. Hal ini bisa menjadi mediapenularan bakteri yang serius karena media tersebut disentuh oleh orang yang berbeda-beda, yang dimana ternyata handle pintu yang disentuh terdapat kuman.Penelitian ini bertujuan untuk mengetahui angka kuman pada handle pintu gedung Direktorat dan mengetahui angka kuman pada handle pintu gedung prodi D-III Teknologi Laboratorium Medis kampus A Poltekkes Kemenkes Kaltim. Jenis penelitian ini adalah bersifat penelitian deskriptif. Jumlah handle dalam penelitian ini sebanyak 46 usap handle pintu, yaitu 23 handle pintu pada gedung Direktorat dan 23 handle pintu gedung prodi D-III Teknologi Laboratorium Medis kampus A Poltekkes Kemenkes Kaltim cara pengujiannya menggunakan metode Angka Lempeng Total (ALT) dengan pengenceran mulai dari (10-1 – 10-4 ) menggunakan media Plate Count Agar (PCA). Hasil dari penelitian ini yaitu Angka Lempeng Total dari gedung Direktorat sebanyak 23 usap handle pintu 100% positif dengan nilai (5,0 × 10-1 CFU/gr) dan ALT dari gedung D-III TLM sebanyak 22 handle pintu 96% positif dengan nilai (1,0 × 10-1 CFU/gr). Dari hasil penelitian ini dapat di simpulkan bahwa handle pintu pada gedung Direktorat 100% positif kuman dan handle pintu pada gedung D-III TLM 96% positif kuman.
Gambaran Telur Cacing pada Kangkung yang Dijual di Pasar Segiri
Authors: Safitri Annisa Eka , Azahra Sresta , Nur Rica Fitri
Published: March 2024

Penyakit yang menjadi masalah kesehatan bagi masyarakat Indonesia salah satunya ialah infeksi yang diakibatkan oleh cacing yang ditularkan dari tanah yang sering disebut dengan Soil Transmitted Helminth (STH). Parasit yang termasuk ke dalam golongan ini ialah Ascaris lumbricoides, Trichuris trichiura, Strongyloides stercoralis, Ancylostoma duodenale, dan Necator americanus. Penelitian ini bertujuan mengetahui ada tidaknya telur cacing STH pada sayuran kangkung dengan tiga perlakuan yang berbeda yaitu dengan perlakuan tidak dicuci, dicuci dengan air mengalir, dan dicuci dengan air sabun. Penelitian ini bersifat deskriptif, penelitian dilakukan di Laboratorium Parasitologi Poltekkes Kemenkes Kaltim Tahun 2021. Sampel yang digunakan adalah kangkung yang dijual di pasar Segiri. Teknik pengambilan sampel menggunakan tenik simple random sampling dengan analisis univariat. Penelitian ini menggunakan data primer yang diperoleh dari hasil uji laboratorium dengan pemeriksaan metode Sedimentasi. Hasil penelitian ini didapatkan hasil negatif telur STH pada sampel yang  diperiksa namun ditemukan 3 sampel positif larva rhabditiform pada perlakuan ang tidak dicuci.
The Validitas Modul Keanekaragaman Hayati Berbasis Pendekatan Saintifik Untuk Siswa Fase E
Authors: Sari Risa Indriana , Rosba Evrialiani , Zikra Zikra
Published: March 2024

Penelitian ini bertujuan untuk menghasilkan modul keanekaragaman hayati berbasis pendekatan saintifik untuk siswa fase E yang valid. Jenis penelitian pengembangan menggunakan model pengembangan 4-D yaitu define, design, develop, dan disseminate. Penelitian ini hanya sampai tahap pengembangan yaitu tahap uji validitas. Instrument penelitian menggunakan angket yang terdiri dari 4 aspek penilaian diantaranya kelayakan isi, kebahasaan, penyajian, dan kegrafikan. Pengujian angket dilakukan pada 4 orang ahli. Teknik analisis data meliputi data primer yang diperoleh dari kuesioner yang di isi oleh validator dan dianalisis menggunakan skala likert. Berdasarkan hasil penelitian diperoleh validitas dari empat aspek yaitu kelayakan isi sebesar 89 % dengan kriteria sangat valid, aspek kebahasaan 93 % dengan kriteria sangat valid, aspek penyajian 88 % kriteria sangat valid dan aspek kegrafikan sebesar 92 % dengan kriteria sangat valid. Hasil nilai dari keseluruhan untuk uji validitas modul diperoleh nilai 90 % dengan kriteria sangat valid.  Dengan demikian kesimpulannya modul keanekaragaman hayati berbasis pendekatan saintifik untuk siswa fase yaitu sangat valid.
Implementasi Metode Qiro’ati pada Anak di TK Al-Azhar 1 Samarinda
Authors: Muyasaroh Muyasaroh
Published: March 2024

Metode dalam belajar membaca Al-Qur’an merupakan cara atau teknik yang diterapkan pada proses pembelajaran agar tercapai tujuan yang diinginkan yakni dapat lancar, baik dan benar ketika membaca al-Qur’an. Metode Qiro’ati ialah teknik yang dilakukan dengan cara langsung memasukkan dan mempraktikkan bacaan Al-Qur’an secara tartil sesuai dengan hukum dalam ilmu tajwid. Ini adalah penelitian kualitatif. Oleh karena itu pendekatan yang digunakan dalam penelitian ini adalah penelitian lapangan. Subjek sebagai sumber data dalam penelitian ini adalah guru dan kepala sekolah TK Al-Azhar 1 Samarinda. Pengumpulan data dilakukan dengan observasi partisipatif, wawancara, dan dokumentasi. Teknik analisis data dilakukan dengan reduksi data, display data, penarikan kesimpulan data dan verifikasi.   Program yang diterapkan saat pembelajaran Qiro’ati yakni klasikal individual. Adapun faktor pendukung pada penerapan metode Qiro’ati di TK Al-Azhar 1 yaitu: guru yang sudah profesional, waktu belajar yang cukup, sarana lengkap dan prasarana yang menunjang, orang tua yang mendukung serta hadiah sebagai apresiasi.
Upaya Meningkatkan Kemampuan Motorik Kasar Anak Melalui Gerak dan Lagu Usia 5-6 Tahun Kelompok B di RA Ma’arif NU 003 Palaran
Authors: Raga Armadi , Muslimah Heriyanti Nur Muslimah Nur , Suyatno Devi Nur Amalia , Saparuddin Muhammad
Published: March 2024

Penelitian ini meruapakan Penelitian Tindakan Kelas (PTK) yang terdiri dari prasiklus dan siklus I di RA Al-Islamiyah Al-Khalidiyah Samarinda dengan subjek 15 anak Kelompok B. Penelitian ini melibatkan tahapan perencanaan, pelaksanaan, observasi, dan refleksi. Hasil penelitian menunjukkan peningkatan sebesar 5% pada presentase 72% di prasiklus menjadi 77% di siklus I. Kesimpulannya, permainan meronce dapat meningkatkan konsentrasi pada anak. Selanjutnya, penelitian membahas relevansi dan pentingnya perkembangan motorik pada anak usia dini, dengan fokus pada aspek motorik kasar dan halus. Pembelajaran gerak dan lagu disoroti sebagai metode yang efektif untuk meningkatkan keterampilan motorik kasar anak. Dalam implementasinya, guru berperan penting dalam memberikan stimulus dan pembelajaran yang sesuai dengan perkembangan anak, khususnya dalam konteks gerak dan lagu. Pada tahap Metodologi, penelitian dilaksanakan di RA Ma’rif NU 003 Palaran Kelas B dengan 10 anak sebagai subjek. Siklus penelitian terdiri dari siklus 1 dan siklus 2, dengan empat tahap: perencanaan, pelaksanaan, pengamatan, dan refleksi. Data hasil penelitian menunjukkan adanya peningkatan yang signifikan dalam kemampuan motorik kasar anak setelah penerapan metode gerak dan lagu. Hasil dan Pembahasan menunjukkan rata-rata skor motorik kasar anak meningkat dari 56,3% pada prasiklus menjadi 80,6% pada siklus 1. Siklus 2 menghasilkan peningkatan lebih lanjut, mencapai rata-rata 89%. Hal ini menunjukkan bahwa metode gerak dan lagu efektif dalam meningkatkan kemampuan motorik kasar anak. Refleksi pada siklus 1 mengidentifikasi keberhasilan dan area perbaikan, yang kemudian direspons dan disesuaikan pada siklus 2.
Pengawasan Orang Tua terhadap Penggunaan Gadget pada Anak Usia Dini
Authors: Sari Wulan , Machmud Hadi , Anhusadar Laode
Published: March 2024

Tujuan penelitian ini untuk memberikan gambaran tentang bagaimana bentuk penggunaan gadget pada anak usia 5-6 dan bentuk pengawasan orang tua terhadap penggunaan gadget pada anak usia 5-6 tahun di Desa Sumberjaya Kabupaten Konawe Selatan. Pendekatan yang digunakan adalah pendekatan deskriptif dengan metode penelitian kualaitatif. Sumber data dari penelitian ini diperoleh dari informan yaitu orang tua dari anak-anak yang gemar bermain gadget dan tokoh masyarakat Desa Sumberjaya. Teknik pengumpulan data dilakukan dengan wawancara dan observasi. Teknik analisis data yang digunakan adalah model interaktif yang dikembangkan oleh Miles dan Huberman yang terdiri dari tiga teknik, yaitu reduksi data, penyajian data dan panarikan kesimpulan. Hasil penelitian ini menunjukan bahwa bentuk penggunaan gadget pada anak usia dini yang ditemukan di Desa Sumberjaya Kabupaten Konawe Selatan : dengan penggunaan  aplikasi youtube oleh 10 anak, penggunaan aplikasi tiktok oleh 4 anak dan penggunaan aplikasi game oleh 2 anak. sementara untuk bentuk pengawasan orang tua pada penggunaan gadget anak usia 5-6 tahun di Desa Sumberjaya Kabupaten Konawe Selatan yaitu terdapat 9 orang tua yang memberi nasehat, 6 orang tua yang memberi batasan waktu dan 4 orang tua yang memberikan sanksi. Bentuk-bentuk pengawasan orang tua sangat penting dilakukan dalam penggunaan gadget pada anak agar anak tidak kecanduan gadget dan perkembangannya tidak terganggu.
Penggunaan Media Permainan Tradisional Tembak Tutus Untuk Meningkatkan Kognitif Anak Usia Dini
Authors: Aida Nur , Muzakki Muzakki , Saudah Saudah
Published: March 2024

Penelitian ini bertujuan untuk mengetahui penggunaan media permainan tradisional tembak tutus dan peningkatan kognitif anak kelompok abu bakar usia 4-5 tahun dalam penggunaan media permainan tradisional tembak tutus di RA Ar-Raudhah Desa Hampalit Kabupaten Katingan. Penelitian ini menggunakan penelitian tindakan kelas (PTK) yang dilakukan dalam dua siklus dengan model Kemmis dan MC Taggart; setiap siklus terdiri dari empat pertemuan. Tempat penelitian  dilaksanakan di RA Ar-Raudhah Desa Hampalit Kabupaten Katingan. Subjek penelitian anak kelompok abu bakar  usia 4-5 tahun yang terdiri dari 13 anak. Tehnik pengumpulan data menggunakan observasi, dokumentasi, dan wawancara. Kriteria keberhasilan penelitian sebesar 85%, untuk menentukan berhasilan atau tidak dalam penelitian. Berdasarkan hasil penelitian menunjukkan bahwa penggunaan media permainan tradisional tembak tutus pada siklus I, perkembangan kognitif anak belum mencapai tingkat perkembangan yang optimal, diadakan perbaikan langkah-langkah penggunaan media permainan tradisional tembak tutus pada siklus II. Selanjutnya dalam perkembangan kognitif anak mengenal pola ABC, dan mengenal lambang huruf, serta menulis huruf yang telah dicontohkan belum berkembang secara optimal pada pra siklus diperoleh hasil sebesar 38,4%. Siklus I hasil rata-rata diperoleh sebesar 62,1%, tetapi belum mencapai indikator keberhasilan atau target yang harus dicapai sebesar 85%, sehingga dilanjutkan lagi pada siklus kedua menghasilkan rata-rata sebesar 93,7% dan kriteria penilaian berkembang sangat baik (BSB).