bluuebunny/crossref_metadata_2025 huggingface dataset:
Profile of Mole Concept Engagement in Class XI IPA-5 SMA Negeri 2 Sampit Academic Year 2018/2019
Authors: Uswatun Nurkamila  , Made Sadiana  , Arifin
Published: September 2023

This research was a descriptive research. The research respondents were 30 students of class XI IPA-5 SMA Negeri 2 Sampit for the 2018/2019 academic year. The research data was obtained through lesson plans, tests, and interviews. The results showed that the average mastery of students' concepts was 64% and was in the medium category. 40% (12 students) of concept mastery are in the high category, 36.67% (11 students) are in the medium category and 23.33% (7 students) are in the low category. As many as 86% (in the high category) students were able to convert the number of moles to the number of particles, mass and volume of substances with mastery of. Meanwhile, 30% (in the low category) students are able to apply the mole concept in solving chemical calculations with mastery of concepts.
Pengaruh Persepsi Harga, Promosi, Dan Desain Kemasan Terhadap Minat Beli Konsumen AMDK Merek ADES
Authors: Oppy Nisrina Muflihah  , Heri Susanto  , Dewi Fitrianti
Published: September 2023

ABSTRACT

This study aims to determine the effect of perceived price, promotion, and packaging design on consumer buying interest in ADES brand bottled drinking water (AMDK), both partially and simultaneously. The sample used in this study was 120 respondents. The analytical method used is multiple linear regression with the dependent variable being consumer buying interest, and the independent variable being price perception, promotion, and packaging design. The results showed that promotion partially had no effect on consumer buying interest, price perceptions and packaging design had a partial effect on consumer buying interest. Perceived variables of price, promotion, and packaging design simultaneously affect consumer buying interest. Of the two influential independent variables, the packaging design variable has the greatest influence on consumer buying interest.

Keywords: Perceived Price, Promotion, Packaging Design, Consumer Purchase   Interest
Factors Influencing Students’ Attitudes Towards Learning English for Specific Purposes
Authors: Pham Lan Anh , Huynh Thi My Duyen
Published: September 2023

Students' learning attitudes have been widely believed to be able to affect their learning outcomes. The paper examines Vietnamese students’ attitudes towards learning English for Specific Purposes (ESP) at the tertiary level. It also considers factors influencing their attitudes towards learning ESP. A questionnaire of 50 items was utilized to collect data from 251 non-English majored students. The research results revealed that the participants had favorable attitudes towards learning ESP in general and even towards factors in the ESP learning process such as teachers, classroom environment, course books and tests. Moreover, the findings indicated teachers had the most influential effect on the students’ attitudes to ESP learning, while tests had the least influential one. Some pedagogical implications can be drawn from the research results for the improvement of students’ learning attitudes and ESP learning outcomes.
Reflections on Cass Sunstein’s Beatlemania article: romantic behaviouralism?
Authors: Duffett Mark
Published: September 2023

In the first issue of this journal, Cass Sunstein offered a behaviouralist reading of the Beatles’ audience. He suggested that the band became a worldwide sensation based on the spread of endorsements by Beatles people acting in line with behavioural norms, such as trust in others’ aesthetic judgements and a need to be liked. This article aims to critically analyse Sunstein’s work by looking at the data sources he used, assessing the applicability of his claims, and considering the ideological effects of what I call a romantic behaviouralist approach. Alongside Sunstein’s ideas, a neo-Durk-heimian reading is suggested to account for interesting regularities of fan behaviour. My aim is not to discredit the mechanisms of human behaviour discussed by Professor Sunstein, but to question the grounding assumptions behind a behavioural approach to popular culture history, and suggest that the application of some proposed behavioural mechanisms might be limited by other elements at play.

This article was published open access under a CC BY licence:
https://creativecommons.org/licences/by/4.0
.
I made the news today, oh boy: the story of uncovering the ‘Beatles at Stowe School’ tapes
Authors: Ahmed Samira
Published: September 2023

This article was published open access under a CC BY licence:
https://creativecommons.org/licences/by/4.0
.
Dispositifs autour de la notion d’univers d’auteur
Authors: Laroque Lydie , Fradet-Hannoyer Marthe , Similowski Kathy , Masson Frédérique
Published: September 2023

Dans un contexte de transformation de la formation des enseignants impliquant de nouvelles relations de partenariat entre les formations académiques et les formations assurées en INSPÉ, l’article aborde les dispositifs mis en place autour de la notion d’univers d’auteur dans la formation initiale des professeurs stagiaires et dans la formation continue, en relation avec un réseau Canopé. Il cherche à mettre au jour les enjeux et les outils pour la formation et interroge ce qui fonde la culture commune entre des équipes de formation pluricatégorielles. Après avoir présenté la notion d’univers d’auteur et le cadre théorique, il examine les dispositifs mis en place à l’INSPÉ et à Canopé, puis compare les démarches d’équipes de formateurs. L’objectif est de saisir les relations entre savoirs pratiques et théoriques au sein des dispositifs de formation, de comprendre comment les équipes conçoivent l’univers d’auteur et comment elles articulent les savoir et savoir-faire en jeu pour constituer les dispositifs de formation. L’article se clôt sur l’approfondissement du travail en formation initiale par la présentation de la méthodologie suivie, de l’analyse des traces des professeurs stagiaires et de celles des élèves.
L’Âge des orateurs. Le tournant rhétorique de la littérature en français autour de 1400
Authors: Doudet Estelle
Published: September 2023

À partir de 1400, s’est développée une culture littéraire en langue moderne dominée par le paradigme rhétorique, contemporaine de la renaissance italienne mais volontairement différente d’elle. Pour comprendre ce nouvel âge des orateurs et analyser la manière dont il a influencé l’activité littéraire en français, trois dimensions du tournant rhétorique sont étudiées : la cicéronisation de l’auctorialité ; les transformations des formes de l’écriture et des valeurs permettant de juger les œuvres ; les interactions avec les publics et les nouvelles formes de sociabilité littéraires.
De la persuasion en poésie : Horace au xvi e siècle
Authors: Goyet Francis
Published: September 2023

Les commentateurs rhétoriques du xvi e  siècle européen voient les poèmes comme des discours visant à persuader, et leur appliquent la même grille de lecture. Ils en dégagent donc la thèse et les arguments à l’appui de cette thèse, ce qui revient à « faire le lien » entre divers passages du texte, selon le sens originel de sullogizein en grec : lier ( sun ) un propos ( logos ) à un autre. Des syllogismes en poésie ? L’article affronte ce scandale, à partir d’un livre récent qui fait d’Horace l’emblème d’une poésie pour laquelle une lecture rhétorique est un contresens.
Entre standardisation et variation : les protestations de reconnaissance dans les lettres de Mme de Sévigné
Authors: Lignereux Cécile
Published: September 2023

La civilité du xvii e  siècle étant très normée, la rhétorique épistolaire du temps obéit sans surprise à des codes. Mme de Sévigné semble leur échapper, tant cette mère est expansive à l’excès. Et pourtant, ces excès apparents répondent en tout point aux codes explicités dans les manuels. L’article le démontre à propos des protestations de reconnaissance. Ses trois parties sont les trois éléments-clés de toute lettre de remerciement : (1) les témoignages de joie et de sensibilité ; (2) l’éloge des bienfaits reçus ; (3) l’assurance d’une gratitude éternelle (qui elle-même se décline en trois « lieux »). Il ne s’en déduit ni originalité ni conformisme. La correspondance de Mme de Sévigné illustre plutôt la marge de manœuvre considérable que permettent les modèles rhétoriques.
Affective subjectifications and social media
Authors: Hasenöhrl Syntia
Published: September 2023

À la lumière de l'intérêt croissant pour les liens entre l'utilisation des médias sociaux par les diasporas et les relations de pouvoir entre les sexes, cet article analyse comment les subjectivations affectives façonnent les perceptions et les expériences de liminalité de deux femmes de la diaspora malienne dans les médias sociaux. En m’appuyant sur les interactions en ligne, j’explique comment ces femmes ressentent les sentiments de déconnexion physique et d’exclusion sociale comme les soumettant aux relations de pouvoir patriarcales et nationalistes, et comment elles ont toutes deux développé des stratégies pour façonner cette distance afin de continuer à articuler leurs opinions comme leur contribution à la justice sociale. Je soutiens donc que la combinaison stratégique de la dé/connexion physique, émotionnelle et numérique permet à ces femmes de rester des sujets sociopolitiquement actifs au sein de leurs positionnalités intersectionnelles.
Se ressentir en exil et le communiquer
Authors: Peraldi-Mittelette Pierre
Published: September 2023

À partir d’une ethnographie menée depuis 2011 auprès de Touaregs installés en France, cet article questionne le terme « diaspora » comme un outil de regroupement ethnique. Au-delà, l’emploi de ce vocable implique des tribunes où les ambiances et les représentations ont des rôles d’accélérateur de perception de soi et d’une identité partiellement mise en scène. Basée sur des interactions entre Touaregs et non-Touaregs, la réflexion portera sur la présentation d’une diaspora encore peu étudiée, puis sur l’emploi d’un terme qui a ses logiques propres parmi les membres de la communauté pour enfin saisir comment les mises en scène et les ambiances se joignent aux revendications identificatoires touarègues en France.
Sexualité et classe sociale : hiérarchies, distinctions et politisations
Authors: Maudet Marion , Monteil Lucas
Published: September 2023

Les sciences sociales ont depuis longtemps montré que la sexualité ne peut être comprise indépendamment des autres dimensions de la vie sociale dans laquelle elle s’inscrit et par lesquelles elle acquiert sens et forme. Cet article revient d’abord sur la manière dont les sciences sociales, en particulier la sociologie et la science politique, abordent la sexualité, avant de proposer une synthèse critique des travaux et enjeux liés à son articulation avec la classe sociale.
Enquêter sur la sexualité et la classe
Authors: Clair Isabelle , Rault Wilfried , Tissot Sylvie , Maudet Marion , Monteil Lucas
Published: September 2023

Les travaux croisant sexualité et classes sociales ont différentes filiations théoriques, épistémologiques et méthodologiques. Cet entretien croisé retrace trois parcours de recherches innovantes ayant marqué depuis une quinzaine d’années la réflexion en sociologie et science politique françaises concernant l’articulation classe/sexualité. En explicitant les étapes et conditions de la mise en problème de l’articulation de ces deux rapports sociaux de pouvoir et, plus largement, les cuisines de la production scientifique, Isabelle Clair, Sylvie Tissot et Wilfried Rault proposent un retour d’une grande réflexivité sur leur parcours, jalonné d’importantes transformations culturelles, sociales et propres au champ académique.
On a lu pour vous – Comprendre les organisations… enfin !, de Henry Mintzberg
Authors: Jézéquel Myriam
Published: September 2023

Nous vivons dans un monde « organisé » à l’extrême, depuis notre naissance à l’hôpital jusqu’à notre cérémonie funéraire. « Entre-temps, nous sommes éduqués, employés, divertis et exaspérés par des organisations », souligne le professeur émérite Henry Mintzberg. Pour autant, que comprenons-nous vraiment de leur fonctionnement ? Analyse et synthèse.
Disséquer les mécanismes de la polarisation
Authors: Venne Jean-François
Published: September 2023

Le marketing peut-il aider à mieux prévenir la polarisation et la radicalisation ? Cette question intrigante fait l’objet d’un récent numéro spécial du Journal of Public Policy & Marketing codirigé par un professeur et une chargée de cours de HEC Montréal.
« Auprès de mon arbre » : un dispositif groupal et généalogique pour accueillir la destructivité
Authors: Tyrol Jacques , Mitsopoulou-Sonta Aglaïa-Lila , Veuillet-Combier Claudine
Published: September 2023

Dans une perspective psychanalytique, la destructivité peut être entendue comme ce que le Moi utilise et pour sauvegarder ses limites et pour demeurer actif face à une menace de débordement et de désorganisation. C’est dans un tel double sens que nous l’explorons ici dans un contexte intersubjectif. L’élaboration qui suit est issue d’un dispositif thérapeutique groupal pour enfants appelé « Auprès de mon arbre », qui prend appui sur la libre réalisation de l’arbre généalogique ( lra g). L’illustration clinique développée dans cet article permet de souligner l’intérêt de ce dispositif innovant en ce sens que le double étayage du groupe et du médium généalogique peut permettre à un enfant de parvenir à mettre des mots là où la souffrance des origines, de la filiation, l’en empêche.
Les figures de l’emprise groupale
Authors: Chouvier Bernard
Published: September 2023

Si la destructivité est à l’œuvre dans les groupes spontanés, elle n’en est pas moins active dans les groupes institués. L’Église prise pour modèle par Freud dans la Massenpsychologie a développé une violence radicale envers les hérésies, tout au long de son implantation temporelle. De même que dans le champ politique, le couple idéalisation-persécution est au centre du fonctionnement groupal. Lorsque l’individu entre à l’intérieur d’un groupe à croyance extrême, il est soumis à une sujétion progressive qui s’apparente à un véritable processus d’aliénation. Une relation d’emprise totale s’instaure entre le nouvel adepte, le chef et les membres de la communauté autour des positions dogmatiques avancées. L’énergumène représente l’une des figures les plus radicales, dans la mesure où il s’engage totalement dans la fureur fanatique. La recherche du martyre conduit nombre d’adeptes au sacrifice selon le modèle d’une auto-apocalypse programmée. De retour du djihad, certains militants s’engagent dans la repentance. Soit ce mouvement est une dissimulation, soit une réelle prise de conscience. On constate également l’apparition d’une théorie de l’attentisme : un repli communautaire pour se préparer à l’avènement futur de la société idéale.
Le mal-être des soignants face à l’âgisme et au vieillissement psychopathologique :gériatrie et psychothérapie institutionnelle
Authors: Mesquita Mirka , Le Cornec Ubertini Anne-Hélène , Pellen Nadine , Gentric Armelle
Published: September 2023

Cet article est issu d’une étude interdisciplinaire en sciences humaines et sociales visant l’analyse de l’impact de l’âgisme sur le fonctionnement d’une équipe soignante en gériatrie. Nous avons réalisé une étude de terrain appuyée sur des observations non participantes dans le quotidien du service, suivie d’entretiens individuels avec les professionnels. La dynamique de travail de cette équipe est rythmée par la symptomatologie associée au vieillissement psychopathologique, en forte hausse dans le service depuis les dernières années. Les soignants témoignent d’un épuisement psychique face à la violence exacerbée des patients et des questionnements éthiques qui en découlent. Nous empruntons quelques concepts de la psychothérapie institutionnelle afin d’élaborer une réflexion éthique sur une logique du soin qui prend en compte les aspects de discrimination dont sont victimes les personnes âgées en souffrance psychique. L’équipe soignante en gériatrie subit indirectement le poids de la double aliénation, mentale et sociale, des personnes âgées démentes et leur mal-être est un symptôme de ce nouveau malaise sociétal.
La fonction pythique, le rythme, la voix et la trace
Authors: Frossard Matthieu
Published: September 2023

Cet article a pour visée de mettre en lumière une des fonctions du groupe nommé pythique inspirée du rituel autour de la pythie dans la Grèce antique. Elle a émergé à partir de la pratique dans un groupe de parole ayant lieu deux fois par jour en semaine dans un service de psychiatrie pour adulte animé de la philosophie de la psychothérapie institutionnelle et se déploie bien au-delà de ce premier cadre. La fonction pythique s’inscrit dans un rythme, par une voix qui fait trace dans un emboîtement interprétatif. L’auteur développe ces différentes notions dans un registre métapsychologique à travers ses expériences en Amazonie et la lecture des auteurs de la créolité. Ce faisant, il esquisse une thérapeutique groupale pour des sujets aux prises avec des processus psychotiques.
Fractional comparative analysis of Camassa-Holm and Degasperis-Procesi equations
Authors: Jawarneh Yousef , Yasmin Humaira , Al-Sawalha M. Mossa , Shah Rasool , Khan Asfandyar
Published: September 2023

This paper focuses on novel approaches to finding solitary wave (SW) solutions for the modified Degasperis-Procesi and fractionally modified Camassa-Holm equations. The study presents two innovative methodologies: the Yang transformation decomposition technique and the homotopy perturbation transformation method. These methods use the Caputo sense fractional order derivative, the Yang transformation, the adomian decomposition technique, and the homotopy perturbation method. The inquiry effectively solves the fractional Camassa-Holm and Degasperis-Procesi equations, which also provides a detailed numerical and graphical comparison of the solutions found. The results, which include accurate solutions, derived solutions, and absolute error displayed in tabular style, demonstrate the effectiveness of the suggested procedures. These procedures are iterative, which results in several answers. The estimated absolute error attests to the correctness and simplicity of these solutions. Especially in plasma physics, these approaches may be expanded to handle various linear and nonlinear physical issues, including the evolution equations controlling nonlinear waves.
Chaos control and numerical solution of time-varying fractional Newton-Leipnik system using fractional Atangana-Baleanu derivatives
Authors: Almutairi Najat , Saber Sayed
Published: September 2023

Nonlinear fractional differential equations and chaotic systems can be modeled with variable-order differential operators. We propose a generalized numerical scheme to simulate variable-order fractional differential operators. Fractional calculus' fundamental theorem and Lagrange polynomial interpolation are used. Two methods, Atangana-Baleanu-Caputo and Atangana-Seda derivatives, were used to solve a chaotic Newton-Leipnik system problem with fractional operators. Our scheme examined the existence and uniqueness of the solution. We analyze the model qualitatively using its equivalent integral through an iterative convergence sequence. This novel method is illustrated with numerical examples. Simulated and analytical results agree. We contribute to real-world mathematical applications. Finally, we applied a numerical successive approximation method to solve the fractional model.
The existence of positive solutions for high order fractional differential equations with sign changing nonlinearity and parameters
Authors: Zhang Luchao , Liu Xiping , Yu Zhensheng , Jia Mei
Published: September 2023

By constructing an auxiliary boundary value problem, the difficulty caused by sign changing nonlinearity terms is overcome by means of the linear superposition principle. Using the Guo-Krasnosel'skii fixed point theorem, the results of the existence of positive solutions for boundary value problems of high order fractional differential equation are obtained in different parameter intervals under a more relaxed condition compared with the existing literature. As an application, we give two examples to illustrate our results.
A global optimization generation method of stitching dental panorama with anti-perspective transformation
Authors: He Ning , Jin Hongmei , Li Hong'an , Li Zhanli
Published: September 2023

To address the limitation of narrow field-of-view in local oral cavity images that fail to capture large-area targets at once, this paper designs a method for generating natural dental panoramas based on oral endoscopic imaging that consists of two main stages: the anti-perspective transformation feature extraction and the coarse-to-fine global optimization matching. In the first stage, we increase the number of matched pairs and improve the robustness of the algorithm to viewpoint transformation by normalizing the anti-affine transformation region extracted from the Gaussian scale space and using log-polar coordinates to compute the gradient histogram of the octagonal region to obtain the set of perspective transformation resistant feature points. In the second stage, we design a coarse-to-fine global optimization matching strategy. Initially, we incorporate motion smoothing constraints and improve the Fast Library for Approximate Nearest Neighbors (FLANN) algorithm by utilizing neighborhood information for coarse matching. Then, we eliminate mismatches via homography-guided Random Sample Consensus (RANSAC) and further refine the matching using the Levenberg-Marquardt (L-M) algorithm to reduce cumulative errors and achieve global optimization. Finally, multi-band blending is used to eliminate the ghosting due to unalignment and make the image transition more natural. Experiments show that the visual effect of dental panoramas generated by the proposed method is significantly better than that of other methods, addressing the problems of sparse splicing discontinuities caused by sparse keypoints, ghosting due to parallax, and distortion caused by the accumulation of errors in multi-image splicing in oral endoscopic image stitching.
Cell replacement with stem cell-derived retinal ganglion cells from different protocols
Authors: Luo Ziming , Chang Kun-Che
Published: September 2023

Glaucoma, characterized by a degenerative loss of retinal ganglion cells, is the second leading cause of blindness worldwide. There is currently no cure for vision loss in glaucoma because retinal ganglion cells do not regenerate and are not replaced after injury. Human stem cell-derived retinal ganglion cell transplant is a potential therapeutic strategy for retinal ganglion cell degenerative diseases. In this review, we first discuss a 2D protocol for retinal ganglion cell differentiation from human stem cell culture, including a rapid protocol that can generate retinal ganglion cells in less than two weeks and focus on their transplantation outcomes. Next, we discuss using 3D retinal organoids for retinal ganglion cell transplantation, comparing cell suspensions and clusters. This review provides insight into current knowledge on human stem cell-derived retinal ganglion cell differentiation and transplantation, with an impact on the field of regenerative medicine and especially retinal ganglion cell degenerative diseases such as glaucoma and other optic neuropathies.
Pathophysiological changes of muscle after ischemic stroke: a secondary consequence of stroke injury
Authors: Qi Hu , Tian Dan , Luan Fei , Yang Ruocong , Zeng Nan
Published: September 2023

Sufficient clinical evidence suggests that the damage caused by ischemic stroke to the body occurs not only in the acute phase but also during the recovery period, and that the latter has a greater impact on the long-term prognosis of the patient. However, current stroke studies have typically focused only on lesions in the central nervous system, ignoring secondary damage caused by this disease. Such a phenomenon arises from the slow progress of pathophysiological studies examining the central nervous system. Further, the appropriate therapeutic time window and benefits of thrombolytic therapy are still controversial, leading scholars to explore more pragmatic intervention strategies. As treatment measures targeting limb symptoms can greatly improve a patient’s quality of life, they have become a critical intervention strategy. As the most vital component of the limbs, skeletal muscles have become potential points of concern. Despite this, to the best of our knowledge, there are no comprehensive reviews of pathophysiological changes and potential treatments for post-stroke skeletal muscle. The current review seeks to fill a gap in the current understanding of the pathological processes and mechanisms of muscle wasting atrophy, inflammation, neuroregeneration, mitochondrial changes, and nutritional dysregulation in stroke survivors. In addition, the challenges, as well as the optional solutions for individualized rehabilitation programs for stroke patients based on motor function are discussed.
Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence
Authors: Liu Xiaoyan , Liu Yi , Liu Junlin , Zhang Hantao , Shan Chaofan , Guo Yinglu , Gong Xun , Cui Mengmeng , Li Xiubin , Tang Min
Published: September 2023

A growing body of evidence suggests that the gut microbiota contributes to the development of neurodegenerative diseases via the microbiota-gut-brain axis. As a contributing factor, microbiota dysbiosis always occurs in pathological changes of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. High-throughput sequencing technology has helped to reveal that the bidirectional communication between the central nervous system and the enteric nervous system is facilitated by the microbiota’s diverse microorganisms, and for both neuroimmune and neuroendocrine systems. Here, we summarize the bioinformatics analysis and wet-biology validation for the gut metagenomics in neurodegenerative diseases, with an emphasis on multi-omics studies and the gut virome. The pathogen-associated signaling biomarkers for identifying brain disorders and potential therapeutic targets are also elucidated. Finally, we discuss the role of diet, prebiotics, probiotics, postbiotics and exercise interventions in remodeling the microbiome and reducing the symptoms of neurodegenerative diseases.
Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies
Authors: Berardo Andrés , Bacaglio Cristian R. , Báez Bárbara B. , Sambuelli Rubén , Sheikh Kazim A. , Lopez Pablo H. H.
Published: September 2023

JOURNAL/nrgr/04.03/01300535-202404000-00035/inline-graphic1/v/2023-09-09T133047Z/r/image-tiff

Anti-ganglioside antibodies are associated with delayed/poor clinical recovery in Guillain-Barrè syndrome, mostly related to halted axon regeneration. Cross-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inhibition of nerve repair inin vitroandin vivoparadigms of axon regeneration. These effects involve the activation of the small GTPase RhoA/ROCK signaling pathways, which negatively modulate growth cone cytoskeleton, similarly to well stablished inhibitors of axon regeneration described so far. The aim of this work was to perform a proof of concept study to demonstrate the effectiveness of Y-27632, a selective pharmacological inhibitor of ROCK, in a mouse model of axon regeneration of peripheral nerves, where the passive immunization with a monoclonal antibody targeting gangliosides GD1a and GT1b was previously reported to exert a potent inhibitory effect on regeneration of both myelinated and unmyelinated fibers. Our results demonstrate a differential sensitivity of myelinated and unmyelinated axons to the pro-regenerative effect of Y-27632. Treatment with a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-GD1a/GT1b monoclonal antibody-mediated inhibition of axon regeneration of unmyelinated fibers to skin and the functional recovery of mechanical cutaneous sensitivity. In contrast, the same dose showed toxic effects on the regeneration of myelinated fibers. Interestingly, scale down of the dosage of Y-27632 to 5 mg/kg resulted in a significant although not complete recovery of regenerated myelinated axons exposed to anti-GD1a/GT1b monoclonal antibody in the absence of toxicity in animals exposed to only Y-27632. Overall, these findings confirm thein vivoparticipation of RhoA/ROCK signaling pathways in the molecular mechanisms associated with the inhibition of axon regeneration induced by anti-GD1a/GT1b monoclonal antibody. Our findings open the possibility of therapeutic pharmacological intervention targeting RhoA/Rock pathway in immune neuropathies associated with the presence of anti-ganglioside antibodies and delayed or incomplete clinical recovery after injury in the peripheral nervous system.
Diagnostic value of WB-DWI versus 18F-FDG PET/CT for the detection of multiple myeloma
Authors: Zhang Bei , Zhang Li , Bian Bingyang , Lin Fang , Zhu Zining , Wang Jiping
Published: September 2023

Background:

Whole-body diffusion-weighted imaging (WB-DWI) is commonly used for the detection of multiple myeloma (MM). Comparative data on the efficiency of WB-DWI compared with F-18 fluoro-2-deoxy-d-glucose positron emission tomography-computed tomography (18F-FDG PET/CT) to detect MM is limited.

Methods:

This was a retrospective, single-center study of 22 patients with MM enrolled from January 2018 to December 2019. All patients underwent WB-DWI and 18F-FDG PET/CT. Pathological and clinical manifestations, as well as radiologic follow-up, were used for diagnosis. The overall accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of both methods were compared. The apparent diffusion coefficient (ADC) values of MM lesions and false-positive lesions were estimated.

Results:

A total of 214 MM bone lesions were evaluated. There was no significant difference in the accuracy of WB-DWI and PET/CT (86.92 versus 88.32%). Though WB-DWI had a higher sensitivity (99.26% versus84.56%) and PET-CT had a higher specificity (96.10% versus 64.56%), these differences were not statistically significant. There was a statistically significant difference in PPV (83.33% versus 96.64%) and NPV (98.08% versus 77.89%) of WB-DWI and PET/CT, respectively. The ADC value for MM lesions was significantly lower than that for false-positive lesions (P < 0.001). Receiver operating curve analysis showed that the AUC was 0.846, and when the cut-off value was 0.745 × 10-3 mm2/s, the sensitivity and specificity were 86.3 and 83.4%, respectively, which distinguished MM lesions from non-MM lesions.

Conclusion:

WB-DWI and PET-CT scans have similar overall accuracy for detecting MM lesions. The higher PPV of PET-CT and NPV of WB-DWI make them complementary imaging modalities. The ADC value for MM lesions is significantly lower than that for false-positive lesions. An ADC cutoff value of 0.745 × 10-3 mm2/s results in sensitivity and specificity of 86.3 and 83.4%, respectively.
Second stem cell transplantation for treatment of relapsed/refractory multiple myeloma after first autologous stem cell transplant: A 15-year retrospective institutional analysis
Authors: Yadav Neha , Mirgh Sumeet P. , Aggarwal Mukul , Agrawal Narendra , Mehta Pallavi , Khushoo Vishvdeep , Kapoor Jyotsna , Bhatia Niharika , Agrawal Pragya , Ahmed Rayaz , Bhurani Dinesh
Published: September 2023

Background:

Multiple myeloma remains an incurable disease, with the majority of patients relapsing after autologous stem cell transplant (ASCT). After relapse, second transplant remains one of the therapeutic options, along with novel agents.

Methods:

We reviewed the data of our patients who underwent ASCT for myeloma (N = 202) over the last two decades (2004–2019). Of these, 12 patients underwent a second transplant.

Results:

Out of 12 patients, nine underwent second autologous stem cell transplant, whereas three received an allogeneic stem cell transplantation (Allo-SCT). Median progression-free survival (PFS) after the first ASCT was 32 months (5–84 months). Median interval between both the transplants was 35 months (4–159 months). Median age of our cohort which underwent second transplant was 56 years. Overall response rate (ORR) post-second transplant on day +100 was 83.3%, without any transplant-related mortality (TRM). With the use of preemptive plerixafor, none of our patients required a second day for stem cell harvest. Median CD34 dose of stem cells infused was 4.11 × 106/kg. Similar to the first ASCT, the median time to neutrophil and platelet engraftment was 11 and 12 days, respectively. At a median follow-up of 41 months, estimated 3-year PFS and overall survival (OS) was 37% ± 15% and 63% ± 15%, respectively.

Conclusion:

Among all relapsed myeloma patients who were transplant eligible, 11% underwent a second transplant. Second transplant is well tolerated with similar time to engraftment after first ASCT. Hence, we believe that second transplant is a feasible, cost-effective option in a resource-limited setting, which should be more widely utilized.
A Comparative Analysis of Collaborative Natural Resource Governance in Two Protected Areas in Zambia
Authors: Kampinda Luaba  , Kobus Mulle  , Paul Vedeld  , Vincent R. Nyirenda
Published: September 2023

In Zambia, early models of natural resource governance were based on state-centric approaches to conservation and later, to some degree, based on Community-Based Natural Resource Management (CBNRM) models. Both of the models delivered poorly in terms of improved biodiversity management, enhanced rural livelihoods, and rights-based benefits. A lack of productive dialogue, involvement, and participation of local communities in natural resource governance resulted in considerable conflicts between protected area managers and local communities, with substantial local political and socio-economic costs. Through a mixed-methods approach using a questionnaire, focus group discussions, and key informant interviews, the Environmental Governance Systems (EGS) framework was applied to compare how interactions among political, economic, and civil society actors influence resource use and the state of resources in the state-led Kaingu chiefdom and the community-managed Kaindu Community Conservancy. Results show limited communication, cooperation, and coordination among the actors in both cases. Conflicting interests over the use of land, wildlife, forests, and fisheries among actors have led to strained relationships, limited interactions, and many negative outcomes in both cases. Both protected areas exhibit a top-down structure of natural resources governance with limited community participation, conflictual relationships among actors, corruption, lack of transparency, and low accountability. The CBNRM structures and processes need to be changed legislatively to improve local ownership and a sense of responsibility and legitimacy by restructuring the constitutions of CBNRM organizations and developing their human resource, financial, and logistical capacities. The study proposes a proactive transformative model for mitigating negative impacts on the state of resources and resource use.
Contribution of Microfinance Institutions in the Growth of Small and Medium Enterprises in Tanzania: Evidence from Trade Enterprises in Moshi Municipality
Authors: Prosper J Kimaro
Published: September 2023

Small and Medium Enterprises (SMEs) in developing and developed countries play a vital role in economic development. Despite their crucial role in the economy, SMEs continue failing in large numbers due to various problems that Microfinance Institutions (MFIs) claim to offer solutions such as access to finance. This study intended to assess microfinance institutions' contribution to SMEs' growth. Precisely, the study aimed at examining the contribution of credit to SMEs, determining the extent to which entrepreneurial training contributes to the growth of SMEs, and examining the contribution of MFIs technological innovations to the growth of SMEs. The study used a cross-sectional research design with a sample size of 231 respondents to collect the information required. Multiple Regression Analysis (MRA) and descriptive statistics were used in data analysis, whereas graphs and tables were used to present the results. It was found that MFIs play an important role in providing services to SMEs. With access to credit, the adjusted R2 was 50.3%, indicating a highly positive relationship between access to credit and SMEs’ growth. The results of entrepreneurial training also showed an adjusted R2 of 38.8%, implying a normal positive relationship between entrepreneurial training and SMEs’ growth. It can, therefore, be concluded that MFIs play an important role in facilitating the growth of SMEs. However, it was also revealed that the SMEs were still struggling to have a high pace of growth due to unfavorable credit terms, less entrepreneurial training, and low awareness of technological innovations. The study recommended that the MFIs improve the credit terms, and the government should also intervene in the activities of MFIs by creating policies aiming to favor the SMEs to improve the sector.
“One Health Approach” Towards Effective Health Services Delivery in Sixty Years of Independent Tanzania
Authors: Mikidadi M. Muhanga  , Edwin E. Ngowi
Published: September 2023

The year 2021 marked sixty years of Tanzania’s independence. Tanzania passed through different phases of development and attempted innumerable interventions, including a series of "development alternatives" to fight poverty, hunger, and infectious diseases. These efforts towards effective health services provision treated humans, animals, and environmental health separately. Due to the increase in human, livestock, wildlife, and environment interactions, the efforts did not result in the anticipated health outcomes. This prompted the government to search for an alternative approach. Cognizant of this, the government introduced the "One Health Approach (OHA)", which recognizes health as one, without a dividing line between humans, animals, and environmental health. This paper, therefore, analyzes (i) the debates for advancing effective health services delivery sixty years after independence; (ii) an emerging approach for interdisciplinary collaboration for human, animal, and environmental health, which is considered to have the potential for effective delivery of health services; and, (iii) the relevance of the OHA towards minimizing the undesirable impacts of human, livestock, and wildlife interactions on health. A documentary analysis (documentary research method) was employed to gather the information for the study. OHA is at its infancy stage, though this initiative signifies an essential landmark towards dealing with health-related challenges reflected at the convergence of humans, animals, and the environment. The milestone is outstanding as it leads to building fundamental capacities concerning public health, particularly regarding preparedness and response as per International Health Regulations. The OHA underscores the need for collaborative working efforts involving human, livestock, wildlife, and environmental health professionals for optimal human, animal, and environmental health attainment. There is a need to upscale the OHA and further understand the consequences of the interactions for optimum human, animal, and environmental health. Therefore, it conveys the idea that it is necessary to expand and enhance the OHA and the importance of comprehending the implications of the interactions for the well-being of humans, animals, and the environment.
Direct evaluation of skills, knowledge and behaviours of pharmacists in the Republic of Ireland
Authors: Kennedy Mary-Claire , Bradley Catriona , Arnett Richard
Published: September 2023

The approach to reviewing Continuing Professional Development (CPD) for pharmacists in Ireland has undergone significant change over the past decade. All registered pharmacists must maintain an electronic portfolio of their CPD, which is reviewed periodically. Patient-facing pharmacists may also be randomly selected to participate in Practice Review. This consists of a clinical knowledge multiple choice question (MCQ) examination (Clinical Knowledge Review (CKR)) and interactions with simulated patients centred on pharmaceutical care cases ((Standardised Pharmacy Interactions (SPIs)). The processes underpinning Practice Review are described and a summary of the performance outcomes of pharmacists since the inception of the review process in 2018 are outlined. To date 310 patient-facing pharmacists have participated in Practice Review with the vast majority demonstrating competence. The significance of these results in the context of assessing competence is considered and the merits and limitations of Practice Review are discussed.
A REVIEW STUDY ON THE EFFICACY OF LEKHANIYA MAHAKASHAYA IN THE
MANAGEMENT OF STHAULYA (OBESITY)
Authors: N. Lal Suman , U. Atram Seema , R. Talmale Sanjay , B. Patil Bhavesh
Published: September 2023

The 21st century, with its constant altering in life styles, environment, and dietary habits has made man the victim
of many diseases; Sthaulya (Obesity) is one of them. Obesity has become a major health problem over the world,
affecting people of all ages, sex, ethnicities, and races. The incidence of obesity has doubled in the past 30 years.
At present in India about 30 million Indians are obese. Currently, medicines available for obesity carry high costs
and serious adverse effects. There is a need to create evidence-based awareness regarding the use of Ayurvedic
medicines in the management of obesity. Acharya Charaka has described Lekhaniya mahakashaya which helps in
reducing excessive fat (Lekhan karma) due to its Ushna, Tikshna, and Ruksha Guna. So it is useful in obesity as
well as Hyperlipidaemia. Lekhaniya mahakashaya significantly reduces Weight and BMI. Santarpana janya vikara as explained in Ayurvedic classics produces Medo-dushti, which is a root cause of many diseases. Administration of Lekhaniya mahakashaya which is Tikta-Katu in Rasa (Bitter taste), Ushna Veerya (Hot in potency), Laghu
and Ruksha (light and dry qualities); Katu Vipaka and is thus Vata Kaphahara. These all properties are against
Medo dhatu which helps to reduce fat in the body. Hence Lekhaniya mahakashaya can be effectively used in the
management of obesity.
A SINGLE DRUG CHIKTSA: MUSTA CHURNA IN SHOTHA (A CASE STUDY)
Authors: K. Handibag Dhanshree
Published: September 2023

The term Shotha ordinarily means a swelling that may be because of the inflammatory process in any part of the
body or may be general due to causes other than inflammatory. Shotha occurring in any part of the body may occur as either Swatantra Vyadhi (primary) or Paratantra (secondary) condition. (“Ayurvedic management of
papilledema Rajagopala M, Gopinathan G - Ayu”) Shotha is a Tridoshaja vyādhi. Excess consumption of curd,
mud, polluted leafy vegetables, and incompatable foods also cause shotha. Alasaka, Visuchika, Swasa, Kasa, Rajayakshama, Pandu, Jwara, Udarda, Pradara, Bhagandara, Arshas, if not treated properly, then also Shotha may
develop. Shotha causes due to trauma, accident, injuries, animal poisonous and burns. Because of etiological factors, tridoshas get vitiated, and it turns vitiated Rakta dhatu and settles in srotasa, i.e., blood vessels, causing avarodha or obstruction in them. As a result, doshas get diverted (vimarga gamana) and start accumulating under the
skin and muscle. In this process, rasa, rakta, and udaka get vitiated with kidney and urinary tract Mustak (Cyperus
rotandus ) acts as deepan, pachan, mutral and uttam malshodhak drug. mustaka also having raktaprasadak quality.
due to its laghu ruksha guna it absorb excess raktagat dravata. Mustaka also acts as an aartava shodhan, a stanyashodhana drug. It means Mustaka is an act on the reasons sthanas, srotasa dushti cause shotha, that's why mustaka is used as a single drug in shoth chikitsa.
EFFICACY OF SAPTAPARNA SNUHI KSHARSUTRA IN THE MANAGEMENT OF
BHAGANDARA (FISTULA IN ANO ): A CASE STUDY
Authors: Suman Pallavi , Ansari Kainat
Published: September 2023

Fistula in Ano is a chronic inflammatory condition having a tubular structure with an opening in the Anorectal
canal at one end and the surface of the perineum or perianal skin on the other end. Fistula-in ano is one such condition that is prone to recurrence even after repeated surgery and can be effectively treated by Ayurvedic medicines. Ksharasutra is one of the chief modalities in the treatment of Bhagandara in Ayurvedic science. Here is a
case report of 31 years male patient with chief complaints of pain and pus discharge from the perianal region presented to Shalya OPD on Oct 14, 2022. After his consent, Ksharsutra treatment was planned with Saptaparna
Snuhi Ksharsutra, along with some oral medications. The treatment continued for a period of 1 month, and the
patient was kept on follow-up for 6 months having no reoccurrence or any other complaints.
Studies on Groundwater Pollution: A Case Study of Beenaganj-Chachura Block
Authors: Kumar Ahirwar Sanjeev , Iyer Murthy Yogesh
Published: September 2023

The present research work investigates the impact of natural and anthropogenic inputs on the chemistry and quality of the groundwater in the Beenaganj-Chachura block of Madhya Pradesh, India. A total of 50 groundwater samples were examined for Nitrates, Fluoride, chlorides, TDS, Calcium, Magnesium, pH, total hardness and conductivity and their impact on Entropy Weighted Water Quality Index (EWQI) and pollution index of groundwater (PIG) was investigated. According to analytical findings, Ca, Mg, Cl-, SO42-, and NO3- exceed the desired limit (DL) and permitted limit (PL) set by the Bureau of Indian Standards (BIS) and the World Health Organization (WHO). According to PIG findings, 76%, 16%, and 8% of groundwater samples, respectively, fell into the insignificant, low, and moderate pollution categories.
Exploring Word Embeddings for Text Classification: A Comparative Analysis
Authors: Satya Mohan Chowdary G  , T Ganga Bhavani  , D Konda Babu  , B Prasanna Rani  , K Sireesha
Published: September 2023

For language tasks like text classification and sequence labeling, word embeddings are essential for providing input characteristics in deep models. There have been many word embedding techniques put out in the past ten years, which can be broadly divided into classic and context-based embeddings. In this study, two encoders—CNN and BiLSTM—are used in a downstream network architecture to analyze both forms of embeddings in the context of text classification. Four benchmarking classification datasets with single-label and multi-label tasks and a range of average sample lengths are selected in order to evaluate the effects of word embeddings on various datasets. CNN routinely beats BiLSTM, especially on datasets that don't take document context into account, according to the evaluation results with confidence intervals. CNN is therefore advised above BiLSTM for datasets involving document categorization where context is less predictive of class membership. Concatenating numerous classic embeddings or growing their size for word embeddings doesn't greatly increase performance, while there are few instances when there are marginal gains. Contrarily, context-based embeddings like ELMo and BERT are investigated, with BERT showing better overall performance, particularly for longer document datasets. On short datasets, both context-based embeddings perform better, but on longer datasets, no significant improvement is seen.In conclusion, this study emphasizes the significance of word embeddings and their impact on downstream tasks, highlighting the advantages of BERT over ELMo, especially for lengthier documents, and CNN over BiLSTM for certain scenarios involving document classification.