bluuebunny/crossref_metadata_2025 huggingface dataset:
An Efficient Integrated Strategy for Comprehensive Metabolite Profiling of Sakurasosaponin from Aegiceras corniculatum in Rats
Authors: Wang Xiangying , Yang Xiao , Hao Erwei , Xie Jinling , Du Zhengcai , Deng Jiagang , Hou Xiaotao , Wei Wei
Published: August 2024

Objective:

Sakurasosaponin, a primary bioactive saponin from Aegiceras corniculatum, shows potential
as an anti-cancer agent. However, there is a lack of information on its in vivo metabolism. This study
aims to profile the in vivo metabolites of sakurasosaponin in rat feces, urine, and plasma after oral administration.
An efficient strategy using ultra-high-performance liquid chromatography/quadrupole time-of-flight mass
spectrometry was developed, which combined metabolic prediction, multiple mass defects filtering, and highresolution
extracted ion chromatograms for rapid and systematic analysis.

Methods:

Firstly, a theoretical list of metabolites for sakurasosaponin was developed. This was done by considering
the metabolic pathways of saponins. Next, the multiple mass defects filtering method was employed
to identify potential metabolites in feces and urine, using the unique metabolites of sakurasosaponin as multiple
mass defects filtering templates. Subsequently, a high-resolution extracted ion chromatogram was used to
quickly determine the metabolites in rat plasma post-identification in feces and urine. Lastly, the analysis of
accurate mass, typical neutral loss, and diagnostic ion of the candidate metabolites was carried out to confirm
their structural elucidation, and metabolic pathways of sakurasosaponin in vivo were also proposed.

Results:

In total, 30 metabolites were provisionally identified in feces, urine, and plasma. Analysis of metabolic
pathways revealed isomerization, deglycosylation, oxidation, hydroxylation, sulfate conjugation, glucuronide
conjugation, and other related reactions as the primary biotransformation reactions of sakurasosaponin in vivo.

Conclusion:

The findings demonstrate that the designed research strategy effectively minimizes matrix interference,
prevents the omission of low-concentration metabolites, and serves as a foundation for the discovery
of active metabolites of sakurasosaponin.
Effects of High-altitude Hypoxia on Drug Metabolism and Pharmacokinetics of Sedative-hypnotic Drugs and Regulatory Mechanism
Authors: Tian Lu , Liu Guiqin , Han Junjun , Li Xiangyang
Published: August 2024

Sedative hypnotics effectively improve sleep quality under high-altitude hypoxia by reducing central
nervous system excitability. High-altitude hypoxia causes sleep disorders and modifies the metabolism
and mechanisms of drug action, impacting medication therapy's effectiveness. This review aims to provide a
theoretical basis for the treatment of central nervous system diseases in high-altitude areas by summarizing the
progress and mechanism of sedative-hypnotics in hypoxic environments, as well as the impact of high-altitude
hypoxia on sleep.
A Bioinformatic Strategy for Investigating the Mechanism of Hispolon in the Treatment of Triple-Negative Breast Cancer Combined with In vitro Experiments
Authors: Li Junfeng , Bao Jingfei , Wu Lichao , Sun Tengfei , Zhao Junhui , Luo Fei , Tao Fangfang , Liu Wenhong
Published: August 2024

Background:

Hispolon, a phenolic compound isolated from the medicinal yellow fungal mulberry, exhibits a strong anti-triple-negative breast cancer (TNBC) effect. However, the antitumor mechanisms of Hispolon have not been fully explored.

Objective:

In this study, we systematically investigated the mechanism of Hispolon against TNBC based on bioinformatics and in vitro experiments.

Methods:

The Hispolon-related targets were first collected from the SwissTarget database. Differential Expression Genes (DEG) were screened between TNBC and normal breast tissue using the Gene Expression Comprehensive (GEO) dataset. The overlapping targets between Hispolon and DEG were analyzed by plotting Venn maps. Protein-protein interaction (PPI) network was constructed to analyze the interactions among these targets. The focus was on mining the core targets of anti-TNBC effects of Hispolon via the Cytohubba and MCODE plugin of Cytoscape 3.7.2 software. We performed survival analysis on these core targets to screen the best-matched targets, including EGFR, KIT, and PLAU. This correlated strongly with our validation of Hispolon by molecular docking. In addition, Gene Ontology (GO) anal-ysis and KEGG pathway analysis were performed using R software (ClusterProfiler package). Finally, in vitro experiments were performed to assess the accuracy of predicted target genes.

Results:

The ADME results suggested that Hispolon has great potential to develop into a drug. Twenty overlapping targets were screened by matching the 107 targets of Hispolon to the 2,013 targets of TNBC DEG. Seven core targets of Hispolon against TNBC were initially identified, including EGFR, IGFBP3, MMP9, MMP2, MMP1, PLAU, and KIT. GO enrich-ment analysis demonstrated that the biological process of Hispolon acting on TNBC mainly involves lymphocyte activation in immune response and phosphatidylinositol-mediated signal-ing. Additionally, the relaxin signaling pathway, estrogen signaling pathway, proteoglycans in cancer, and others might be the key pathways of Hispolon against TNBC. Furthermore, Hispo-lon inhibited the proliferation of MDA-MB-231 cells in a concentration-dependent manner and regulated the RNA and protein expression of the core targets EGFR, PLAU, and KIT for the treatment of TNBC.

Conclusion:

In this study, the polygenic pharmacological mechanism of action of Hispolon against TNBC was explored through network pharmacology and in vitro experiments, provid-ing a new insight into the mechanism of TCM monomer against TNBC.
Exosomal CircRNAs: A Future Star in Colorectal Cancer
Authors: Zhou Yuanzhi , Wei Chengyan , Xu Yuqi , Wang Jingjing , Zhang Chunwei , Jin Yong
Published: August 2024

Colorectal cancer (CRC) is currently the third most common malignancy world-wide, with an increasing mortality rate and treatment resistance. Due to the lack of effective biomarkers and therapeutic targets, the early diagnosis and treatment of colorectal cancer re-main suboptimal. Circular RNAs (circRNAs) are a novel class of non-coding RNAs with co-valent closed-loop structures that are well stabilized and conserved and are involved in multi-ple pathological conditions in humans. CircRNAs have been identified to be enriched and sta-ble in exosomes. In addition, there is growing proof that exosomal circRNAs that have been identified as oncogenes or tumor suppressors regulate CRC growth, migration, and sensitivity to radiotherapy and chemotherapy. Exosomal circRNAs represent promising candidates as di-agnostic biomarkers and anti-tumor targets. In this article, we explore recent studies on exo-somal circRNAs in CRC and describe their biological functions in colorectal cancer develop-ment, illustrating their potential as biomarkers and targeted therapeutic capabilities.
Recent Advances in the Synthesis of Antioxidant Derivatives: Pharmacological Insights for Neurological Disorders
Authors: Singh Kuldeep , Gupta Jeetendra Kumar , Sethi Pranshul , Mathew Sojomon , Bhatt Alok , Sharma Mukesh Chandra , Saha Sunam , Shamim  , Kumar Shivendra
Published: August 2024

:

Neurological disorders, characterized by oxidative stress (OS) and inflammation, have
become a major global health concern. Redox reactions play a vital role in regulating the balance
of the neuronal microenvironment. Specifically, the imbalance leads to a significant weakening of
the organism's natural defensive mechanisms. This, in turn, causes the development of harmful
oxidative stress, which plays a crucial role in the onset and progression of neurodegenerative diseases.
The quest for effective therapeutic agents has led to significant advancements in the synthesis
of antioxidant derivatives. This review provides a comprehensive overview of the recent
developments in the use of novel antioxidant compounds with potential pharmacological applications
in the management of neurological disorders. The discussed compounds encompass a diverse
range of chemical structures, including polyphenols, vitamins, flavonoids, and hybrid molecules,
highlighting their varied mechanisms of action. This review also focuses on the mechanism
of oxidative stress in developing neurodegenerative disease. The neuroprotective effects of these
antioxidant derivatives are explored in the context of specific neurological disorders, including
Alzheimer's disease, Parkinson's disease, and Huntington's disease. The ultimate goal is to provide
effective treatments for these debilitating conditions and improve the quality of life for patients.
A Comprehensive Review on the Development of Titanium Complexes as Cytotoxic Agents
Authors: Kumar Nitesh , Kaushal Raj , Awasthi Pamita
Published: August 2024

:

After the discovery of cis-platin, the first metal-based anticancer drugs, budotitane, and
titanocene dichloride entered clinical trials. These two classes of complexes were effective against
those cell lines that are resistant to cis-platin and other platinum-based drugs. However, the main
limitation of these complexes is their low hydrolytic stability. After these two classes, a third generation
titanium based complex, i.e. diaminebis(phenolato)bis(alkoxo) titanium(IV), was invented,
which showed more hydrolytic stability and high cytotoxicity than budotitane and titanocene
dichloride. The Hydrolytic stability of complexes plays an important role in cytotoxicity. Earlier
research showed that hydrolytically less stable complexes decompose rapidly into non-bioavailable
moiety and become inactive. The mechanism of Ti(IV) complexes of diaminebis(phenolato)
bis(alkoxo) is under investigation and is presumed to involve Endoplasmic Reticulum (ER)
stress, which leads to apoptosis. The proposed mechanism involves the removal of ligands from
the titanium complex and the binding of the Ti center to transferrin protein and its release inside
the cell. Also, the structure of the ligand plays a key role in the cytotoxicity of complexes; as the
bulkiness of the ligand increased, the cytotoxic nature of complexes decreased.
Posterior Reversible Encephalopathy Syndrome Associated with L-Asparaginase Treatment in Children: Literature Review and Six Case Reports
Authors: Tosta Pérez María Margarita , Belen Lisandra Herrera , Pessoa Adalberto , Avendaño Jorge Farías
Published: August 2024

L-asparaginase (L-ASNase) is an enzyme that shows targeted activity against Acute
Lymphoblastic Leukemia (ALL) and similar lymphoid neoplasms by facilitating the breakdown
of asparagine into L-aspartic acid, thereby reducing L-asparagine levels in leukemic cells. However,
its therapeutic potential is hindered by its associated toxicity, leading to complications,
such as thrombosis, hemorrhage, thrombocytopenia, fibrinolysis, hypersensitivity reactions, and
the development of Posterior Reversible Encephalopathy Syndrome (PRES). This review compiles
documented cases of PRES linked to treating B and T cell acute lymphoblastic leukemia in
children using L-ASNase. Although this pathology is rare, understanding its management is crucial
within ASNase-based chemotherapy protocols. As PRES lacks a specific treatment, focusing
on symptomatic management becomes pivotal. Therefore, comprehending the underlying causes
during L-ASNase treatment for acute lymphoblastic leukemia is essential. Understanding the etiology
and clinical symptoms of this illness is critical for early diagnosis and treatment.
The cases of PRES described in this review include instances in which this syndrome has appeared
after the administration of L-ASNase in children. In some cases, PRES developed during
induction therapy, while in others, it occurred during the reinduction phase. These cases resolved
days after discontinuation of L-ASNase. The findings suggest a close relationship between drug
administration and the appearance of brain lesions, as evidenced by the disappearance or decrease
of these lesions when the drug was eliminated from the bloodstream.
Artificial Intelligence (AI) on Management of Finance and Accounts
Authors: Majeed Mohammed
Published: August 2024

The goal of this chapter is to shed light on how AI is being used in financial
and accounting contexts. The rise of AI is having a profound effect on the accounting
and financial industries, just as it has on every other sector of the economy. The best
approach for financial experts and their businesses to remain successful and engage the
coming generations of workers and consumers is to use AI-enabled tools for
accounting and finance. The era of AI and robotics is just beginning. However,
technological advancements mean that more and more accounting aids are becoming
accessible. Saving money, getting more done, and having more reliable data are all
possible thanks to AI. In addition, it provides accuracy to businesses during the
employment process. Laborious and mundane accounting tasks may be eliminated. In
conclusion, AI has had a spectacular effect on the bookkeeping and finance business,
shifting attention away from mundane tasks like payroll and toward more cutting-edge
methods.
Antimicrobial and Antifungal Potential of Indian Spices
Authors: Sanandia Jalpa , Patel Mousmi , Vadia Nasir
Published: August 2024

Infectious diseases caused by pathogens and food poisoning induced by
spoilage bacteria pose a global hazard to human health. Microbial resistance has
harmed the efficacy of various antimicrobial drugs, which are now used to extend the
shelf life, raise the safety of food products in the food business, and suppress diseasecausing germs in medicine. As a result, new antimicrobial agents that can overcome
resistance must be developed. Many spices, including clove, oregano, thyme,
cinnamon, and cumin, were found to have significant antibacterial and antifungal
activity against food spoilage bacteria like Bacillus subtilis and Pseudomonas
fluorescens, pathogens like Staphylococcus aureus and Vibrio parahaemolyticus,
harmful fungi like Aspergillus flavus, and even antibiotic-resistant microorganisms like
methicillin. In addition to their flavor and aroma features, many spices and herbs used
today are recognized for their antimicrobial and therapeutic properties. Plant extracts
from cinnamon, clove, garlic, mustard, onion, and oregano were sensitive to most
foodborne bacterial pathogens studied. The essential oil portion of spices and herbs
contains many antibacterial chemicals. Antimicrobial compounds in spices were more
responsive to Gram-positive bacteria than those in spices were to Gram-negative
bacteria. The degree of sensitivity differed depending on the strain and climatic
variables. Spices that stimulate acid generation in starting cultures can have a direct
effect on the rate of fermentation. Spices contain antimicrobial compounds such as
phenols, alcohols, aldehydes, ketones, ethers, and hydrocarbons. In the current chapter,
Indian spices and their key antimicrobial components are explored for their
antibacterial activity and ways of action.
Exploring the Therapeutic Potential of Medicinal Plants for Rheumatoid Arthritis
Authors: Bhatti Attya , Arif Ammara , Nawaz Hafiza Ayesha
Published: August 2024

Rheumatoid arthritis is a chronic autoimmune disease that affects the small
joints of the feet and hands, causing polyarticular inflammation. Uncontrolled synovial
tissue is the most prominent symptom of this disease. If left untreated, it can result in
significant impairment, adversely impacting the patient's quality of life and elevating
death risk. Genetic, environmental, and epigenetic variables are all important in the
etiology of this disease. The risk of developing rheumatoid arthritis is not age-related,
people over the age of 40, particularly women, are significantly more likely to get the
disease than men. There are a variety of therapies that are provided based on the
severity of the ailment. However, all of these therapeutic techniques have negative
effects as well as significant prices. More than 80% of the population in the world is
now believed to use medicinal plants to maintain their health. Plants are the most
abundant source of antimicrobial agents, and extracts of numerous edible plant species,
herbs, and spices have long been used to preserve food due to the presence of
potentially powerful antibacterial components. Not only minerals and primary
metabolites are found in medicinal plants, but also a wide range of possible chemical
compounds that aid in the adsorption and neutralization of free radicals. Some of the
plants that show antioxidant and anti-inflammatory properties against rheumatoid
arthritis are discussed in this chapter.
Comparison of Farmer Welfare in Kediri Regency and Probolinggo Regency Based on Farmer Exchange Rates (FER)
Authors: Prayitno Gunawan , Anwar Ruslin , Indrayanto Toni , Permana Mirza , Purnomowati Rahmi
Published: August 2024

Agriculture is an important component of the Indonesian economy and makes a significant contribution to national Gross Domestic Product (GDP). However, the poverty rate among farmers is still high, which shows the need for a more in-depth study of farmer welfare. This study focuses on Kediri Regency and Probolinggo Regency in East Java, areas known for their agricultural contributions. The aim is to assess the welfare of farmers in Kediri Regency and Probolinggo Regency. This research uses a quantitative approach, with data collected through questionnaires and interviews. The analysis used is the Farmer Exchange Rate (FER), which is determined by comparing the Price Index Received by Farmers (It) and the Price Index Paid by Farmers (Ib). The results show significant differences between the two districts, Kediri experienced an increase in FER of 0.48%, while Probolinggo experienced a decrease in FER of 2.87%. This finding is important because it reflects differences in the welfare and economic conditions of farmers in Kediri and Probolinggo. Factors such as government support, adoption of modern technology, and seasonal changes were identified as influencing these outcomes. Strategic recommendations include increasing productivity through technology and starting programs targeting young farmers. This effort aims to improve agricultural effectiveness and the overall welfare of farmers in the region.
Model of Destination Image, Tourist Motivation, Satisfaction, and Revisit Intention in Wendit Waterpark, Malang Regency
Authors: Kalih Shafira Wirawati Dayang , Permata Wijayanti Wawargita , Dinanti Dian , Adelia Suryani Tia , Rapudin Armei , Shafira Salmaa
Published: August 2024

Wendit Waterpark is one of the famous tourist destinations in Malang Greater Area. This research aims to analyze the condition of image destination, tourist motivation, satisfaction, and revisit intention to Wendit Waterpark and examine the relation among those four variables using Structural Equation Model (SEM). Data collection was conducted by using questionnaire with 100 respondents. We applied a descriptive quantitative to identify condition of image destination, tourist’s motivation and satisfaction, and their revisit intention to Wendit. Result shows that there is a significant and strong relation among image destination, motivation, satisfaction, and revisit intention. It means that it is needed some improvements to enhance the condition of image destination of Wendit Waterpark, then it will improve motivation and satisfaction, and also revisit intention to this tourism destination.
Expected Role of the Community in Decision-Making for the Development of Sanankerto Tourism Village, Turen Sub-District, Malang District
Authors: Kurnia Widhiani Sabilla , Dinanti Dian , Helda Leliana Defin , Fauzi Isnan , Bernard Rachman Cyril , Habunga Mostan
Published: August 2024

Sanankerto Tourism Village was recognized as one of the best tourism villages at the 2021 Anugerah Desa Wisata Indonesia award. However, the Covid-19 pandemic led to significant challenges, causing many tourism products and activities to falter. There is now a discourse on revitalizing Sanankerto Tourism Village, highlighting the need to assess the community's willingness to engage in decision-making processes regarding the village's development. Community involvement is crucial to ensure that grassroots ideas, which are vital for development, are incorporated. Engaging the community in the development process is expected to make Sanankerto Tourism Village more advanced, innovative, and creative, while also fostering a sense of ownership and responsibility among the residents. The level of community participation was evaluated using descriptive analysis, scoring, and weighting methods to determine its value. The analysis revealed a score of 1,213.10, placing the community in the Delegated Power category on Arnstein's Ladder of Participation. At this level, the government grants authority to the community for making planning decisions, giving them control over some or all of the programs to be implemented.
Technology transfer as a tool for managing the regional innovation economy
Authors: Belyaeva E. S. , Sotnikov A. A. , Tkacheva T. U.
Published: August 2024

Relevance. The Russian economy is moving to a new innovative level of development, and actively implemented projects in the field of digital transformation form the basis for creating a long-term and secure information and telecommunications infrastructure capable of providing high-speed transmission, processing and storage of large amounts of data, which will be available to a wide range of enterprises.

The purpose of the study is to identify the role of technology transfer in the management of the regional innovation economy and current trends.

Objectives: to study the indicators of Internet use by the population for ordering goods and services in urban and rural areas; to assess the dynamics of gross value added of the ICT sector and GDP; to assess the demand of economic and social sectors for digital technologies; to propose ways to solve these problems of digitalization of Russian enterprises.

Methodology. The methods of system analysis, deduction and induction, analysis and synthesis are used.

Results. Russian enterprises are experiencing significant difficulties in the process of technology transfer to the digital space due to the lack of deep readiness to accept and use open innovations, as well as due to restrictions on the free exchange of intellectual property results and insufficient level of asset sharing. These factors can slow down the pace of technology transfer of enterprises and create obstacles to their competitiveness in today's digital business environment. It is necessary to actively develop technology transfer mechanisms that promote the exchange of knowledge and resources in order to increase efficiency to the new challenges of the digital economy.

Conclusions. Economic measures of technology transfer, including bans on access to foreign digital products and services, have not only negative consequences. Currently, consumers in Russia who are accustomed to using digital solutions from foreign manufacturers are faced with the need to switch to domestic analogues of technology as a result of the restrictions imposed.
A study of the peculiarities of freelance activity of the Russian population on online labor market platforms
Authors: Alyokhina O. F. , Beilina A. F. , Trufanova S. A. , Bashlykov T. V.
Published: August 2024

Therelevanceofthestudyisdeterminedbythe emergence and consolidation of new trends in the implementation of labor activity of the population in the context of digitalization and new challenges, as well as the need for their comprehensive study.

Thepurposeofthe study is to study the peculiarities of freelance activity of the Russian population on online labor market platforms, as well as to identify a set of measures necessary to obtain benefits from the implementation of this type of activity in order to stabilize the labor market during a period of change and reduce social tension.

TheobjectivesofthestudyarerelatedtotheanalysisofsupplyanddemandfortheservicesofRussianfreelancersoninternationalonlinelabormarketplatforms,includingbycomparingitspositions with other countries; identifying measures to optimize the activities of online freelancers and stabilize the labor market during the period of change.

Methodology.Theresearchwasimplementedusingthe method of collecting information from open Internet sources, tabular and graphical methods, the method of economic analysis, analysis and synthesis, systematization, comparison, logical method and systematic approach.

Results.ItisdeterminedthatthefreelanceactivityoftheRussianpopulationintheonlineformathasgreatgrowthpotential.Theprerequisitesforthedevelopmentofonlinefreelancingarehighlighted,aswellasthemotivesforRussianspecialistsenteringthedigitalplatformsofthegloballabormarket.Theanalysisofthesupplyanddemandofonlinefreelancersonthelargestonlineemploymentplatformsintheperiod2017-2022wascarriedout.ThespecificsofRussiaarerevealedincomparisonwiththetrendstypicalforChina, India, Germany, Great Britain and the USA.

Conclusion.Theconclusionismadeaboutthe high activity of Russian freelancers on the online platforms of the global labor market, about the predominantly growing dynamics of this market segment, as well as about the existing restrictions in this area, which can be overcome by greater support from the state.
Voluntary initiatives of non-profit organizations in the formation of creative communities and creative spaces of the city: a philosophical view
Authors: Kasatkina S. S. , Aula E. R.
Published: August 2024

Relevance.Thisarticleexaminesthe topical issue of the role of the non-profit sector in urban development from a philosophical point of view. The authors cite key concepts that reveal the socio-legal aspects of the work of NGOs; define the socio-philosophical significance of the activities of non-profit organizations in Russian cities.

Thepurposeofthe study is to identify the impact of volunteer initiatives of the non-profit sector on the development of creative locations of cities, the dynamics of territorial development.

Objectives:todeterminingthe relationship of NGOs with the development of the creative potential of the city; socio-philosophical analysis of competitive materials of applications from non-profit organizations to civil society development funds; identification of directions for the formation of urban creative and innovative spaces created with the help of NGOs.

Methodology.Theworkusesa systematic method, an analytical review and synthesis of the information under study. The authors used materials from open data reports on the evaluation of the results of the projects of the winners of the competitions for grants from the President of the Russian Federation for the development of civil society in 2022.

Results.Theresultisanideaofthe socio-cultural modernization of the urban sphere. Initiative in the implementation of voluntary urban socially significant projects forms the sustainability of urban living conditions, the investment and image attractiveness of the city, and the positive migration issue. The interrelation between initiative projects of representatives of the non-profit sector and socio-cultural design of the environment, activation of the creative class, and improvement of the comfort level of urban areas is revealed. Modern active NGOs in Russian cities represent the avant-garde, implementing creative projects and broadcasting cultural trends, creative practices that define the conceptual meanings of the development of a particular city (region). Projects based on the voluntary aspirations of citizens and related to the assistance of specific social groups acquire a sustainable character of development and form the features of the city.

Conclusion.Theresultsofthe study showed that the work of the non-profit sector in Russian cities is transforming urban spaces by developing creative resources and creative industries.
Artificial intelligence in state and municipal management: challenges and prospects
Authors: Belyaeva O. V. , Sokolova A. Y.
Published: August 2024

Relevance. In the modern world, artificial intelligence (AI) is one of the fastest growing areas of information technology, which is increasingly penetrating into various spheres of human activity. In the context of public and municipal management, AI is a technology that is able to automate and optimize work processes, improve the quality of services provided to citizens, and increase the level of security and transparency of government work.

The purpose is to analyze the possibilities and risks of using artificial intelligence in state and municipal management, as well as to determine the prospects for its development in this area.

Objectives: to analyze the advantages of using artificial intelligence in state and municipal management; to study the risks and challenges associated with its implementation; to analyze trends in the development of artificial intelligence in this area, as well as to determine the prospects for its use.

Methodology. Empirical, theoretical, statistical and graphical representation methods were used in the course of scientific research.

Results. The study revealed the advantages of AI in public administration (improving efficiency, improving the quality of services, transparency, security); risks and challenges were studied (lack of infrastructure, risk of privacy violations, problems of transparency of algorithms, risk of discrimination); trends in the development of AI were analyzed (e-government, optimization of workflows, personalization of services, monitoring of social media, security); the prospects of using AI (smart cities, virtual assistants, hybrid systems, decision support, cooperation with business, international cooperation) have been identified.

Conclusions. Artificial intelligence can significantly improve the efficiency and quality of public and municipal administration. However, for the successful implementation of AI, it is necessary to solve problems such as the lack of infrastructure and qualified specialists, ensuring data security, transparency of algorithms and compliance with the regulatory framework. To do this, it is necessary to conduct further research, develop integrated approaches and take into account world experience. The prospects for using AI include the creation of smart cities, the use of virtual assistants, hybrid systems, decision support systems, business cooperation and international cooperation.
Dynamics of development of consumer preferences and behavioral patterns of generation Z in the digital economy
Authors: Lapidus L. V. , Gostilovich A. O. , Zhiburt P. E. , Karaseva M. O. , Samokhvalova E. I. , Kozlova E. D.
Published: August 2024

Relevance.In2023,representativesofGenerationZ entered into active competition in the labor market and began to increase their marketing potential, which made this segment of consumers attractive to companies from different fields. Marketers and business development managers continue to study the consumer preferences and behavioral patterns of Generation Z, born in the digital age.

Thepurposeofthe study is to study the dynamics of the development of consumer preferences and behavioral patterns of generation Z in the digital economy.

Objectives:tostudythe dynamics of consumer behavior in the field of e-commerce and methods of online and offline payment; to study the dynamics of consumer preferences of generation Z in the field of reading information from electronic devices.

Methodology.A questionnaire of 37 questions has been developed, divided into 4 groups. 300 respondents from Generation Z living in Moscow and the Moscow region took part. The answers were collected using the Google Forms online resource. The study was conducted at the Faculty of Economics of Lomonosov Moscow State University in the Laboratory of Applied Industry Analysis under the supervision of Professor L. V. Lapidus.

Results.Itwas revealed that from 2019 to 2022, the proportion of respondents who prefer non-cash payment methods increased significantly. The proportion of respondents who pay for purchases online has also increased. The proportion of Generation Z representatives is growing, who find it more convenient to pick up purchases from order pick-up points than to deliver via courier.

Conclusions.identificationoftrends in the development of consumer habits and behavioral patterns: the growth of consumption in online stores and marketplaces; minimization of communications in the "person-to-person" system when paying and receiving online purchases; multiscreen a combination of devices of different types to solve everyday tasks. Based on the results and conclusions of the study, recommendations were formulated for companies engaged in various types of interaction with representatives of Generation Z.
Exploring Cancer Incidence Trends by Age and Sex Among 14.14 Million Individuals in China From 2007 to 2021: Population-Based Study (Preprint)
Authors: Yuan Yingchao , Liu Chang , Guo Moning , Xin Zhong , Chen Guanjie , Yang Yue , Zheng Jianpeng , Zang Bai , Yang Jinkui
Published: August 2024

BACKGROUND

Sex is a crucial factor in the development, progression, and treatment of cancer, making it vital to examine cancer incidence trends by sex for effective prevention strategies.

OBJECTIVE

This study aimed to assess the incidence of cancer in China between 2007 and 2021, with a focus on sex-based trends.

METHODS

A population-based cancer registry comprising 14.14 million individuals was maintained between 2007 and 2021 by the Beijing Municipal Health Big Data and Policy Research Center. The age-standardized rates (ASRs) of cancers were calculated using the Segi population. The average annual percentage of change (AAPC) was evaluated using the joinpoint regression model, while the Bayesian age-period-cohort model was used to predict cancer incidence in the next 10 years.

RESULTS

From 2007 to 2021, the study included 651,342 incident patients with cancer, of whom 51.2% (n=333,577) were women. The incidence indicated by the ASR for all cancers combined was 200.8 per 100,000 for women and 184.4 per 100,000 for men. The increase in incidence indicated by AAPC for all malignancies combined significantly increased in women between 2007 and 2021 (AAPC=3.1%; P<.001), whereas it remained constant in men (AAPC=0.3%; P=.30). Although the overall incidence of all cancers indicated by AAPC increased in young men (AAPC=3.2%; P=.01), the greatest increase was observed among young women (AAPC=6.1%; P<.001). The incidence rate ratio for cancer in women increased among subsequent younger generations compared with patients born in the 1962-1966 cohort. The ASR in women will increase 1.6-fold over the next 10 years, with women having twice the incidence rate of men by 2031.

CONCLUSIONS

The rising incidence of cancer among women in China has become a growing concern, emphasizing the need for increased efforts in cancer prevention and early screening, especially among young women.
The Relevance of Phytate for the Treatment of Chronic Kidney Disease
Authors: Ekramzadeh Maryam , Kalantar-Zadeh Kamyar , Kopple Joel D.
Published: August 2024

Diets high in plant-based foods are commonly recommended for people with CKD. One putative advantage of these diets is reduced intestinal phosphate absorption. This effect has been ascribed to phytic acid (myoinositol hexaphosphoric acid) and its anion, phytate, that are present in many plant foods, particularly in the seeds, nuts, grains, and fruits of plants. This article reviews the structure and many actions of phytate with particular reference to its potential effects on people with CKD. Phytate binds avidly to and can reduce gastrointestinal absorption of the phosphate anion and many macrominerals and trace elements including iron, zinc, calcium, and magnesium. This has led some opinion leaders to label phytate as an anti-nutrient. The human intestine lacks phytase; hence, phytate is essentially not degraded in the small intestine. A small amount of phytate is absorbed from the small intestine, although phytate bound to phosphate is poorly absorbed. Clinical trials in maintenance hemodialysis patients indicate that intravenously administered phytate may decrease hydroxyapatite formation, vascular calcification, and calciphylaxis. Orally administered phytate or in vitro studies indicate that phytate may also reduce osteoporosis, urinary calcium calculi formation, and dental plaque formation. Phytate seems to have anti-inflammatory and antioxidant effects, at least partly because of its ability to chelate iron. Other potential therapeutic roles for phytate, not definitively established, include suppression of cancer formation, reduction in cognitive decline that occurs with aging, and amelioration of certain neurodegenerative diseases and several gastrointestinal and metabolic disorders. These latter potential benefits of phytate are supported by cell or animal research or observational studies in humans. Many of the above disorders are particularly common in patients with CKD. Definitive clinical trials to identify potential therapeutic benefits of phytate in patients with CKD are clearly warranted.
Using Evaluation to Boost the Moral Development of Junior High School Students: Exploration of the Moral Evaluation Mechanism Based on the English Subject
Authors: Deng Yingchuan , You Jiawen
Published: August 2024

Due to the transitional, closed, social, and turbulent characteristics of their psychological development, the evaluation of the moral development of junior high school students should focus on the dynamic evaluation of their daily performance and growth. This exploration of the moral evaluation mechanism for junior high school students precisely starts from this criterion, based on the characteristics of the English subject, takes “all-round education” as the cornerstone of the evaluation, uses the three dimensions of core competencies as the basis for evaluation, and adopts multiple evaluation and progressive implementation methods as the guide to conduct a diverse and objective assessment of the morality of junior high school students. With the expectation of achieving the ultimate goal of developing students’ individual specialties and promoting the comprehensive development.
A Comparative Study on the Use of Evaluative That Patterns in Abstracts by Expert and Novice Writers
Authors: Feng Linhao
Published: August 2024

This study investigates the differences in how expert and novice writers use evaluative that-complement clauses in abstracts. The research analyzed 150 research article abstracts and 100 master’s thesis abstracts in the social sciences, applying the model of “evaluative that patterns” with the assistance of the MAXQDA annotation tool and ChatGPT retrieval mode. The analysis reveals that both groups often use this pattern to present their findings, typically attributing evaluations to abstract sources. They primarily express epistemic stances through verbal predicates. However, experts demonstrate significantly greater use of every element (entity, source, stance, and expression) of this feature. Experts are more inclined to use human resources and discourse act verbs and prefer to evaluate prior studies and methods, expressing more tentative stances to foster a dialogic space. These findings suggest that expertise influences rhetorical strategies for evaluating research materials. The study highlights pedagogical implications, offering valuable insights for novice writers in the social sciences to help them understand how to effectively use linguistic resources to convey evaluative claims and establish authoritative authorial stances.
A Study about Linguistic Landscape in Shaping City Image under the CIS Strategy of Internationally Important Ramsar Sites in Yunnan Province
Authors: Deng Yingchuan
Published: August 2024

This study, guided by the City Identity System (CIS) strategic model, investigates the linguistic landscape (such as signage and public notices) of four international important wetlands (Ramsar Sites) in Yunnan Province (Lashihai, Dashanbao, Bitahai, Napahai). Taking Yunnan Province’s Ramsar Sites as examples, the current status of linguistic landscapes in ecological wetland areas is surveyed, and the role of ecological linguistic landscapes in enhancing the urban ecological image is explored. This paper also focuses on the phenomenon of multilingual linguistic landscape use. After identifying the problems in the linguistic landscapes of the aforementioned four wetlands, corresponding strategies and suggestions are proposed. This study seeks to promoting the standardized, multilingual, and multi-modal nature of linguistic landscapes in ecological areas, providing theoretical basis and practical evidences for the construction of Green and Beautiful Yunnan Strategy, and in a hope to better global understandings of China’s ecological civilization.
The Dilemma and Choice of “Nora’s Departure” of Sexual Transversion —Taking “the Second Half of Shen Congwen’s Life” as an Example
Authors: Kemei Wang
Published: August 2024

Throughout Shen Congwen’s life, the great leap of identity has added legendary color to him. The starting point of all changes can be traced back to the period of Xiangxi. At the age of 14, he joined the army, tasted the warmth of human feelings in the army, and finally promoted to the scholar’s document with his own efforts. However, his yearning for freedom made him finally give up his well-paid stable work and go to Beijing alone with his dream to seek another form of independence. The classic female character Nora created in the “Doll’s House” seems to operate a happy life in the eyes of outsiders, and her heart has a demand for freedom and independence beyond the context of the times. Shen Congwen’s life trajectory in reality may provide a male interpretation for Nora’s text. This article is based on the book “the second half of Shen Congwen’s life”. The book uses a large number of direct quotes, detailed letters and various types of literature. It is of great significance to understand Shen Congwen and understand the ups and downs of individuals in the torrent of the times.
Impact of Technological Progress on Consumer Trust and Adoption of E-Banking
Authors: Yadav Mamta
Published: August 2024

Abstract: In this research paper, I have thoroughly described the topic “Impact of Technological Progress on Consumer Trust and Adoption of E-Banking”. The financial services sector has seen a transformation due to the advent of technology improvements, especially with the increasing use of electronic banking, or e-banking. Traditional banking methods have been transformed by the advancement of digital technology, which has made it easier to create complex financial systems and services that are available via a variety of electronic devices. But even as these developments provide potential, a serious worry emerges about the complex relationship that exists between e-banking adoption, customer trust, and technical improvement. Building effective banking relationships requires a lot of trust, particularly in the digital sphere where fraud, privacy, and data security are major problems. The increasing dependence of customers on e-banking for financial operations necessitates a high degree of trust between the technology and the organizations providing these services. However, customer opinions of security, dependability, usability, and overall value are just as important in determining whether or not e-banking is adopted as a banking option as technical developments. To create an environment that is favorable for digital financial services, financial institutions and regulators need to understand the subtleties of customer trust and how it affects the adoption of e-banking in the context of technical improvements. In order to shed light on the opportunities, problems, and consequences in the rapidly changing field of digital finance, this paper will examine the complex relationship that exists between technological advancement, consumer confidence, and acceptance of e-banking. The abstract emphasizes the symbiotic link between trust and adoption, indicating that as trust in e-banking services grows, so does the adoption rate, underscoring the importance of technology innovation in reshaping the banking landscape.
IONIC LIQUIDS AS POTENTIAL CO-CATALYST FOR CO2 ELECTROCHEMICAL REDUCTION
Authors: Mohammed Sulafa Abdalmageed Saadaldeen , Yahya Wan Zaireen Nisa , Bustam Mohamad Azmi , A.Hassan Muzamil , Masri Asiah Nusaibah , Kibria Md Golam
Published: August 2024

Carbon dioxide electrochemical reduction (CO2ER) presents numerous advantages in mitigating greenhouse gas emissions by converting CO2 into value-added chemicals and can be integrated with renewable energy sources such as solar and wind. Nevertheless, establishing an electrochemically stable catalytic system that can effectively decrease the overpotential while maintaining high current density and faradaic efficiency is challenging. The precise mechanisms causing the reactions and the specific functions of the electrode with electrolytes are still not fully understood. Hence, a significant increase in attention has been paid to using ionic liquids (ILs) as electrolytes for CO2ER. This phenomenon is attributed to the unique capabilities of ILs to reduce overpotential, increase current density, and improve electrochemical stability. Therefore, this study evaluated the effect of incorporating ILs into electrolytes to comprehend the cation and anion influences on CO2ER reactions. Linear sweep voltammetry (LSV) and chronoamperometry (CA) were employed to examine the reduction peaks and current density values for different electrolytes, respectively. Consequently, a 0.1 M NBu4PF6 acetonitrile solution containing 1-ethyl-3-methylimidazolium tetrafluoroborate [EMIM][BF4] demonstrated a significantly lower onset potential of the reduction by 320 mV. A reduced CO2ER efficiency involving ILs with long alkyl chains was also observed. Meanwhile, a novel hypothesis concerning molecular orbitals for the CO2ER reaction mechanism was discussed. Overall, various performance variables (reduction stability, applied potential, and current density) of CO2ER were improved using cations with short alkyl chains, anions with high highest occupied molecular orbital (HOMO) levels, and appropriate solvation media. These findings can serve as selection criteria to aid in choosing appropriate ionic liquids for CO2 electrochemical reduction (CO2ER).
ANDREY PLATONOV AND LITERARY INSTITUTIONS: ON THE ISSUE OF COMMENTING ON THE EPOCH LEXICON
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Moskovskaya Daria S.
Published: August 2024

The article summarizes the results and prospects designated by the scientific publication of Platonov’s “Works” and describes the political, historical, and literary contexts of the writer’s reconstruction period works, presented in vol. 4. The work on the comments revealed the topical issue of Platonov’s attitude to writers’ unions. His avoidance of personal involvement in any organization is a known fact. Nevertheless, the need for self-realization as a writer and the financial difficulties associated with it led to his entrance into several literary associations. The 1930s became a turning point in Platonov’s creative destiny, which is striking when commenting on his works. His lexicon exposes new semantic overtones of commonly used words and reflects the writer’s dialogue with the authorities, which are embodied, among other things, by writers’ associations, revealing the institutional (social) semantics of everyday objects and phenomena.