bluuebunny/crossref_metadata_2025 huggingface dataset:
Invisible Color Variations of Facial Erythema: A Novel Early Marker for Diabetic Complications?
Authors: Blanes-Vidal Victoria , Majtner Tomas , Avendaño-Valencia Luis David , Yderstraede Knud B. , Nadimi Esmaeil S.
Published: September 2019

Aim. (1) To quantify the invisible variations of facial erythema that occur as the blood flows in and out of the face of diabetic patients, during the blood pulse wave using an innovative image processing method, on videos recorded with a conventional digital camera and (2) to determine whether this “unveiled” facial red coloration and its periodic variations present specific characteristics in diabetic patients different from those in control subjects. Methods. We video recorded the faces of 20 diabetic patients with peripheral neuropathy, retinopathy, and/or nephropathy and 10 nondiabetic control subjects, using a Canon EOS camera, for 240 s. Only one participant presented visible facial erythema. We applied novel image processing methods to make the facial redness and its variations visible and automatically detected and extracted the redness intensity of eight facial patches, from each frame. We compared average and standard deviations of redness in the two groups using t-tests. Results. Facial redness varies, imperceptibly and periodically, between redder and paler, following the heart pulsation. This variation is consistently and significantly larger in diabetic patients compared to controls (p value < 0.001). Conclusions. Our study and its results (i.e., larger variations of facial redness with the heartbeats in diabetic patients) are unprecedented. One limitation is the sample size. Confirmation in a larger study would ground the development of a noninvasive cost-effective automatic tool for early detection of diabetic complications, based on measuring invisible redness variations, by image processing of facial videos captured at home with the patient’s smartphone.
Antibiotic Resistance Patterns of DiverseEscherichia coliPhylogenetic Groups Isolated from the Al-Hillah River in Babylon Province, Iraq
Authors: Alwash Mourouge Saadi , Al-Rafyai Hawraa Mohammed
Published: September 2019

Surface water contamination remains a major worldwide public health concern and may contribute to the dissemination of antibiotic-resistant bacteria. The Al-Hillah River in the city of Babylon Province, Iraq, diverts flows from the Euphrates River. Because of its importance in irrigation and population density, it faces several forced and unforced changes due to anthropogenic activities. To evaluate water quality, water samples were collected from three sites with different anthropogenic pressures along the Al-Hillah River. These samples were subjected to bacteriological analyses, i.e., total coliforms,Escherichia coli, and faecal enterococci. The phylogenetic groups of theE. coliisolates (n = 61) were typed by rapid PCR-based analyses. Representatives of each isolate were tested phenotypically for resistance to six classes of antibiotics and characterized according to their phylogenetic groups. The results demonstrated the highest resistance levels were toβ-lactam antibiotics, followed by fosfomycin and aminoglycosides.Escherichia coliisolates belonging to phylogenetic groups A and B2 were the most common and were characterized by a higher prevalence of antibiotic resistance. This study is important for understanding the current conditions of the Al-Hillah River, as the data reveal a high prevalence of multiresistance amongE. coliisolates circulating at the three sampling sites.
Emphysematous Pyelonephritis Presenting as Pneumaturia and the Use of Point-of-Care Ultrasound in the Emergency Department
Authors: Brown Natasha , Petersen Paul , Kinas David , Newberry Mark
Published: September 2019

Emphysematous pyelonephritis (EPN) is a rare form of pyelonephritis causing a severe infection of the renal system that includes gas in the renal parenchyma, collecting system and surrounding tissue often presenting with sepsis. We report the case of a 60-year-old male with poorly controlled insulin dependent diabetes mellitus who presented with abdominal pain, nausea, vomiting, and “peeing air.” CT scan revealed air extending from the left renal parenchyma, perinephric fat and into the bladder, consistent with emphysematous pyelonephritis. Bedside point-of-care ultrasound (POCUS) subsequently revealed dirty shadowing and reverberation artifacts in the left kidney and the bladder consistent with gas in the urinary collecting system. By understanding the identifying artifacts seen with EPN, reflective shadow and reverberation artifact, the emergency physician may be alerted to the diagnosis sooner. Often this illness presents similarly to simple, acute pyelonephritis or undifferentiated sepsis. Therefore, POCUS allows for real time consideration of this condition while in the emergency department and thus prompter time to treatment.
A Halpern-Type Iteration Method for Bregman Nonspreading Mapping and Monotone Operators in Reflexive Banach Spaces
Authors: Ogbuisi F. U. , Jolaoso L. O. , Isiogugu F. O.
Published: September 2019

In this paper, we introduce an iterative method for approximating a common solution of monotone inclusion problem and fixed point of Bregman nonspreading mappings in a reflexive Banach space. Using the Bregman distance function, we study the composition of the resolvent of a maximal monotone operator and the antiresolvent of a Bregman inverse strongly monotone operator and introduce a Halpern-type iteration for approximating a common zero of a maximal monotone operator and a Bregman inverse strongly monotone operator which is also a fixed point of a Bregman nonspreading mapping. We further state and prove a strong convergence result using the iterative algorithm introduced. This result extends many works on finding a common solution of the monotone inclusion problem and fixed-point problem for nonlinear mappings in a real Hilbert space to a reflexive Banach space.
Comparative Abilities of Body Mass Index, Waist Circumference, Abdominal Volume Index, Body Adiposity Index, and Conicity Index as Predictive Screening Tools for Metabolic Syndrome among Apparently Healthy Ghanaian Adults
Authors: Quaye Lawrence , Owiredu William Kwame Boakye Ansah , Amidu Nafiu , Dapare Peter Paul Mwinsanga , Adams Yussif
Published: September 2019

The prevalence of the metabolic syndrome (MetS) continues to increase. There is therefore the need for early detection to avert possible adverse outcomes. Several anthropometric methods have been suggested to predict MetS, but no consensus has been reached on which is best. The aim of the study was to explore the comparative abilities of conicity index, body adiposity index, abdominal volume index, body mass index, and waist circumference in predicting cardiometabolic risk among apparently healthy adults in the Tamale metropolis. This study was a cross sectional study conducted from September 2017 to January 2018, among one hundred sixty (160) apparently healthy normoglycemic normotensive adults. A self-designed questionnaire was administered to gather sociodemographic data. Anthropometric and haemodynamic measurements were also taken. Blood samples were collected for fasting blood glucose (FBG) and lipid profile. MetS was classified using the harmonised criteria as indicated by the joint interim statement (JIS). Of 160 participants, 42.5% were male and 57.5% were female. Body mass index (BMI) and waist circumference (WC) associated better with MetS and other cardiovascular risk factors. Generally, BMI and WC showed largest area under curves (AUCs) than abdominal volume index (AVI), body adiposity index (BAI), and conicity index (CI) in predicting MetS and its components. Upon gender stratification, AVI and CI had the larger AUCs in females whiles BMI remained the superior index in males. Whiles BMI and WC remained useful parameters, they were not useful in predicting MetS and its components in the female population in this study.
The Genetics of Racing Performance in Arabian Horses
Authors: Ropka-Molik K. , Stefaniuk-Szmukier M. , Musiał A. D. , Velie B. D.
Published: September 2019

Arabian horses are commonly believed to be one of the oldest and most influential horse breeds in the world. The high financial benefits obtained from races tend to search for genetic markers strongly correlated with the results achieved. To date, the modern approaches such as transcriptome, miRNAome, and metabolome analyses have been used to investigate the genetic background of racing performance as well as endurance capacity in Arabians. The analysis of polymorphisms at the genome level has also been applied to the detection of genetic variants associated with exercise phenotype in the Arabian breed. The presented review summarizes these findings, with a focus on the genetics underlying flat racing and endurance performance traits in different Arabian horse populations.
Twelve-Month Retention in and Impact of Enhance®Fitness on Older Adults in Hawai‘i
Authors: Tomioka Michiyo , Braun Kathryn L. , Wu Yan Yan , Holt Kay , Keele Paula , Tsuhako Lori , Yago Johnny
Published: September 2019

Introduction. Enhance®Fitness is a low-cost group exercise program designed specifically for older adults (60+ years) to improve physical performance. The Hawai‘i Healthy Aging Partnership, a statewide health promotion initiative, has continuously offered Enhance®Fitness to Hawai‘i’s multicultural population since 2007. This study examined 12-month participation in and impact of Enhance®Fitness on physical performance among older adults in Hawai‘i. Method. Linear mixed-effects models were applied to analyze the physical performance measures (chair-stands, arm curls, and the up-and-go test) collected at baseline (month 0) and at 4, 8, and 12 months. We also compared the characteristics of participants who participated in the program for 12 months with those who dropped out in order to gain insights on participant retention. Results. Of 1,202 older adults with baseline data, 427 (35.5%) were continuously enrolled in Enhance®Fitness for 12 months and participated in follow-up data collection. On average, participants attended 63.7% of thrice-weekly classes each month. Participants’ physical performance measures improved after 4 months, continued to improve until 8 months, and were maintained thereafter. Besides continuous attendance, performance-measure improvements were associated with younger age, male gender, living with others (vs. alone), and fewer chronic conditions. Compared to those who completed 12 months of the program, the 775 who left the program over the course of the year were more likely to be younger, to be Caucasian (vs. Asian or Pacific Islander), to self-report depression as a chronic condition, and to have lower levels of fitness at baseline. Common reasons for dropping out were illness, relocation, time conflicts, lost interest, and transportation issues. Conclusions. Long-term participants in Enhance®Fitness initially improved and then maintained physical performance. Future research is needed to identify strategies to maintain enrollment of older adults in the exercise programs over time.
Subcutaneous Magnesium Sulfate to Correct High-Output Ileostomy-Induced Hypomagnesemia
Authors: Makowsky Mark J. , Bell Peter , Gramlich Leah
Published: September 2019

Fluid and magnesium abnormalities are common in patients with high-output stomas. Subcutaneous magnesium administration may be more feasible for long-term management in ambulatory patients, but magnesium sulfate is approved only for intravenous or intramuscular injection. We describe the management of chronic hypomagnesemia and dehydration secondary to a high-output ileostomy following radiation and chemotherapy for anal squamous cell carcinoma with intermittent home-based subcutaneous magnesium infusions in a 61-year-old female with a history of Crohn’s disease and multiple bowel resections. Despite aggressive management with intravenous magnesium sulfate and oral magnesium glucoheptonate over 8 months, 49% of her magnesium concentrations were <0.60 mmol/L (mean 0.61 ± 0.09) necessitating 4 emergency, 1 hospital, and 4 infusion clinic visits. After initiation of subcutaneous magnesium sulfate, all magnesium concentrations were >0.60 mmol/L (mean 0.79 ± 0.08 mmol/L over 9 months). The patient tolerated the infusions well, only developing one minor episode of infusion-related cellulitis. A systematic review of the literature identified 14 reports where subcutaneous magnesium sulfatewas effective and treatment for adults or children with hypomagnesemia was safe. Home-based intermittent administration of subcutaneous magnesium may be a helpful and safe intervention to temporarily prevent and treat select patients with recurrent symptomatic hypomagnesemia.
Melanocytic Nevus of the Colon
Authors: Uesugi Noriyuki , Tateno Hiroo , Yokoyama Hiroshi , Abe Shu , Sugimoto Ryo , Sugai Tamotsu
Published: September 2019

Here, we report a very rare case of melanocytic nevus of the colon. A 54-year-old woman with an unremarkable medical history visited our hospital for screening colonoscopy. Colonoscopy revealed a pigmented flat lesion in the ascending colon. Histological evaluation of a biopsy specimen revealed proliferation of pigmented cells in the lamina muscularis propria. On immunohistochemical analysis, pigmented cells were positive for S-100 protein and Melan-A expression, and a diagnosis of colonic melanocytic nevus was made. Although the pathogenesis underlying colonic melanocytic nevi remains unclear, we speculate that colonic melanocytic nevi develop via abnormal migration or differentiation of neural crest cells during embryogenesis.
Krukenberg-Tumoren: Wichtige klinische Fragen sind bisher nicht beantwortet
Authors: Homayounfar Kia
Published: September 2019

Background: The treatment of metachronous Krukenberg tumor (mKT) from gastric cancer remains unexplored. We performed a literature review to evaluate whether or not surgical treatment improves survival. Methods: A systematic review according to PRISMA guidelines was performed. Studies reporting on patients who underwent surgical treatment for mKT from gastric cancer were selected. Metachronous disease was divided as follows: confined to the ovaries, confined to the pelvis, or beyond the pelvis. Outcomes evaluated included overall survival (OS), progression-free survival (PFS), resection rate (R0), and factors predicting survival. Results: 13 retrospective reports fulfilled the selection criteria (512 patients). Most of the patients presented at a premenopausal age. The median presentation interval from gastrectomy ranged from 16 to 21.4 months. Median OS ranged between 9 and 36 months. 1-year OS ranged between 52.5 and 59%, and 3-years OS between 9.8 and 36.5%. Resection margin, peritoneal seeding, and chemotherapy regimen and cycles influenced survival. Conclusion: Surgical treatment and adjuvant chemotherapy in patients with mKT from gastric cancer seems to be associated with improved survival and is justified especially in young patients. Disease location and R0 resection should be considered when selecting patients.
Ungewöhnlicher Fall von myeloproliferativer Neoplasie mit zwei seltenen klonalen Anomalien
Authors: Swaminathan Mahesh , Patel Keyur P. , Huynh-Lu Julie , Tang Guilin , Zuo Zhuang , Miranda Roberto , Verstovsek Srdan
Published: September 2019

Myeloproliferative Neoplasien (MPN) sind klonale Erkrankungen, die in Philadelphia (Ph)-Chromosom-positive chronische myeloische Leukämie (CML) oder Ph-Chromosom-negative MPN unterteilt werden. Das gleichzeitige Auftreten dieser Krankheitsentitäten ist sehr selten und geht typischerweise mit dem Vorliegen des häufigen BCR-ABL-Fusionstranskripts p190 oder p210 (verantwortlich für die CML) in Kombination mit einer JAK2V617F-Mutation (der häufigsten Driver-Mutation bei Ph-negativen MPN) einher. Da derartige Fälle äußerst selten auftreten, ist unklar, ob sich die Outcomes bei den betroffenen Patienten unterscheiden. Im vorliegenden Artikel berichten wir über den ungewöhnlichen Fall eines Patienten mit Polycythämia vera, ausgelöst durch eine seltene komplexe In-Frame-Deletions-Insertionsmutation im Exon 12 des JAK2-Gens, und CML, ausgelöst durch das seltene BCR-ABL-Fusionstranskript p210 e14a3 (b3a3). Wir beschreiben die klinischen und labordiagnostischen Merkmale, die Ergebnisse der histopathologischen Knochenmarkuntersuchung sowie die Behandlung und das Gesamt-Outcome.
Ansprechen auf Imatinib ist bei chronischer myeloischer Leukämie mit BCR-ABL1-Transkriptvariante e13a2 schlechter als bei Transkriptvariante e14a2
Authors: Greenfield Graeme , McMullan Ross , Robson Nuala , McGimpsey Julie , Catherwood Mark , McMullin Mary Frances
Published: September 2019

Hintergrund: Das BCR-ABL1-Fusionsgen, das der Pathogenese der CML zugrunde liegt, kann aus einer Reihe verschiedener Bruchstellen entstehen. Die häufigsten Varianten sind die Transkripte e13a2 und e14a2, die durch Bruchstellen im Bereich von Exon 13 bzw. Exon 14 des BCR-Gens entstehen. Methoden: In einer retrospektiven Analyse werteten wir lokale Labordatenbanken und elektronische Patientenakten von 69 CML-Patienten mit e13a2- oder e14a2-Transkriptvariante aus, die wir in unserer regionalen Population identifiziert hatten. Ergebnisse: Die e13a2-Gruppe war im Durchschnitt signifikant jünger (45,0 Jahre vs. 54,5 Jahre), ihre durchschnittliche Leukozytenzahl war höher (189,8 × 109/l vs. 92,40 × 109/l) und die Thrombozytenzahl niedriger (308 × 109/l vs. 644 × 109/l) als in der e14a2-Gruppe, was darauf hindeutet, dass es sich um unterschiedliche biologische Entitäten handelt. Über einen durchschnittlichen Nachbeobachtungszeitraum von 33,8 Monaten (e13a2) bzw. 27,2 Monaten (e14a2) beobachteten wir ein schlechteres molekulares Ansprechen auf Imatinib in der e13a2-Gruppe. Eine signifikant geringere Anzahl von Patienten im e13a2-Arm erfüllte die Kriterien des European Leukemia Net für ein optimales Ansprechen nach 12-monatiger Therapiedauer (17,64% vs. 50,0%), und es dauerte länger, bis sie ein umfassendes molekulares Ansprechen (MR4 oder MR4.5) erreichten. Schlussfolgerung: In den Populationen unserer Region zeigen Patienten mit einer e13a2-Transkriptvariante ein schlechteres molekulares Ansprechen auf Imatinib.
Nicht-kleinzelliges Lungenkarzinom: Welche Rolle microRNA in der Behandlung spielt
Authors: Reinmuth Niels
Published: September 2019

Background: The role of microRNA-133a (miR-133a) in non-small cell lung cancers (NSCLCs) is controversial. Thus, we conducted a comprehensive study based on meta-analysis and The Cancer Genome Atlas (TCGA) database. Methods: Publications were searched in both English and Chinese databases, and meta-analysis was performed using Stata 12.0. The clinical value of miR-133a in NSCLC was investigated by collecting and calculating data from the TCGA database, and the statistical analysis was performed in R 3.5.0. Results: 5 studies with 364 cases were included in this meta-analysis. The combined pooled result showed that high expression of miR-133a was associated with a favorable survival outcome in NSCLC patients (hazard ratio 0.561, 95% confidence interval 0.396-0.794, p = 0.001). Meanwhile, a total of 984 NSCLC patients were extracted from the TCGA database. Results showed an area under the ROC curve value for miR-133a-3p of 0.902, and the expression of miR-133a-3p was linked with clinicopathologic parameters of NSCLC (p < 0.05), including sex, age, social status, and lymph node metastasis. Conclusion: Our study indicated that miR-133a might act as a tumor suppressor and be a valuable independent prognostic and diagnostic biomarker for NSCLC, and NSCLC patients with high expression of miR-133 might have a better prognosis.
Disease-Related Malnutrition and Sarcopenia as Determinants of Clinical Outcome
Authors: Meyer Fatuma , Valentini Luzia
Published: September 2019

Background: Disease-related malnutrition (DRM) and sarcopenia are common complications in chronic or severe disease, with a prevalence in general patient population of 20–50% and 0.1–85.4%, respectively. In many patient populations, malnutrition and sarcopenia are present in parallel and often manifest clinically through a combination of decreased nutrient intake, inflammation, and decreased body weight, along with a decrease in muscle mass, strength, and/or physical function, resulting in a clinical condition termed malnutrition-sarcopenia syndrome. Summary: DRM and sarcopenia are associated with increases in all-cause mortality, morbidity, length of hospital stay, and functional impairments (including disabilities and fractures) that lead to a loss of independence and higher costs. Different mortality rates are reported in malnourished patients and well-nourished patients after hospitalization, and higher mortality is the most common complication in patients with sarcopenia. Sarcopenia is a predictor of cancer survival in patients with gastrointestinal, respiratory, and urothelial cancer, and is also related to worse outcomes in patients with liver failure, intestinal insufficiency, and intestinal failure. Length of hospital stay has been found to be longer in DRM and sarcopenic patients in several studies. Prolonged hospitalization due to higher complication rates is often accompanied by demographic changes, resulting in higher hospital and health insurance costs. There are more frequent readmissions by patients with sarcopenia than nonsarcopenic patients. In addition, postoperative complications, duration of hospital stay, and costs increase with advancing sarcopenia stage. A significantly higher complication rate is also reported for DRM, leading to delayed mobilization, lower values in health-related quality of life and more adverse events. DRM is independently associated with poorer clinical outcomes in intensive care unit patients. Muscle dysfunction, as reflected by a decreased handgrip strength, is a well-known consequence of DRM and a good marker of immediate postoperative complications. Most of these outcomes have potential direct or indirect effects on hospital and health care costs, both for the patient and the society at large. Key Messages: Consistent and robust data show DRM and sarcopenia are clinically relevant. They are an increasing problem with relevant medical consequences as well as socioeconomic implications.
MiR-421 Is Overexpressed and Promotes Cell Proliferation in Non-Small Cell Lung Cancer
Authors: Li Xing , Chen Shao-Hua , Zeng Jin-Wu
Published: September 2019

Background: Lung cancer is the main cause of cancer-­related deaths worldwide, and the overall 5-year survival rate of non-small cell lung cancer (NSCLC) remained low. ­MicroRNAs had been confirmed to be an important regulator in tumor progression, and they could serve as either tumor promoters or suppressors in NSCLC. Objectives: To identify the novel cancer-specific biomarkers for NSCLC patients, which may be useful to monitor tumor progression and improve NSCLC patients’ survival. Method: The expression profile of miR-421 was analyzed in NSCLC samples using public datasets, including The Cancer Genome Atlas and GSE102286. The expression level of miR-421 was detected by reverse transcription-polymerase chain reaction. Cell proliferation and cell cycle were detected by Cell Counting Kit assay, flow cytometry assay, respectively. Kyoto Encyclopedia of Genes and Genomes analysis were applied to determine the biological roles of miR-421, based on the online DAVID system. Statistical comparisons between groups of normalized data were performed using t test or Mann-Whitney U test according to the test condition. Results: In this study, we focused on exploring the roles of miR-421 in NSCLC prognosis and growth. The present study for the first time showed that miR-421 was overexpressed in NSCLC and associated with a shorter overall survival time of patients with NSCLC. Bioinformatics analysis revealed miR-421 was involved in transcription, cell cycle, and insulin signaling pathway regulation. Furthermore, a gain of function assay showed that overexpression of miR-421 could promote NSCLC cell proliferation and cell cycle progression. Conclusions: Our findings suggest that miR-421 might be a promising prognostic and therapeutic target for NSCLC.
Melioidosis of the Musculoskeletal System
Authors: Perumal Rajamani , Livingston Abel , Samuel Sumant , Govindaraju Santhosh Kumar
Published: September 2019

Objective: Recent studies indicate that India is an endemic region for Burkholderia pseudomallei infection. We aimed to describe the clinical presentation of B. pseudomallei infection of the musculoskeletal system and summarise the various treatment modalities used in our clinical practice. Subjects and Methods: Patients with confirmed microbiological diagnosis of B. pseudomallei infection involving the musculoskeletal system treated from January 2007 to December 2016 with a minimum follow-up of 1 year were included. A retrospective review of medical records was carried out and patients’ demographic data, co-morbidities, clinical presentation, and details of medical and surgical treatment were documented. Results: Of 342 patients diagnosed with B. pseudomallei infection, 37 (9.2%) had musculoskeletal involvement; 26 patients (23 males) followed up for at least a year were included in the study. Four patients (15%) had multisystem involvement and 10 (37%) had multiple musculoskeletal foci of infection; 15 patients (58%) had osteomyelitis, 10 (38%) had septic arthritis with or without osteomyelitis, and 1 patient (4%) presented with only soft tissue abscess. All patients required surgical intervention in addition to medical management. Surgical treatment varied from soft tissue abscess drainage, arthrotomy for septic arthritis, decompression and curettage for osteomyelitis, and/or use of antibiotic (meropenem or ceftazidime)-loaded polymethylmethacrylate bone cement for local drug delivery. At final follow-up (average: 37 months, range: 12–120), all patients were disease free. Conclusion: We found the rate of musculoskeletal involvement in B. pseudomallei infection to be 9.2%. Appropriate surgical treatment in addition to medical management resulted in resolution of disease in all our patients.
Editorial
Authors: Silveira Danilo
Published: September 2019

Editorial
Entrevista com Ana Longoni
Authors: Zamariola Paola Lopes , Longoni Ana
Published: September 2019

Entrevista realizada em 4 de abril de 2019, por Paola Zamariola.
À Mesa
Authors: Dias Kenia
Published: September 2019

Este artigo pretende analisar o objeto-sujeito Mesa do Grupo Galpão, de Minas Gerais como uma possível materialidade para o que podemos chamar de diário, agindo como uma espécie de canteiro documental do grupo, com informações espaciais, verbais, temporais e gráficas que, entre tantos desafios e (re)existências, luta contra o esquecimento de processos. Com um suporte de ferro e um tampo largo e quadrado de madeira gasta, a Mesa, aqui, será analisada como um código móvel em diálogo com as reflexões que compõem o diário Perto: um diário de montagem (ainda não publicado), escrito pelo ator e fundador do grupo, Eduardo Moreira, cuja escrita aconteceu durante o processo de criação da peça Nós, dirigida por Márcio Abreu. O diário também será analisado com o poema-escritura em processo A Mesa, de Francis Ponge, o livro A poética do espaço, de Bachelard, e a teoria de redes de criação de Cecilia Salles.
Memórias de mãe e filha
Authors: Nhur Andréia
Published: September 2019

Este texto-documento traz diferentes fases do Grupo Pró-Posição Dança em suas investigações artísticas no campo da historiografia e da memória. Arquivos, depoimentos, gestos citados e lembranças evocadas pelo movimento anunciam uma dança traçada pelos fluxos de memória entre mãe e filha artistas.
O Teatro de Arte de Moscou e seus arquivos
Authors: Viana Fausto
Published: September 2019

O Teatro de Arte de Moscou (TAM) foi fundado em 1898 por Konstantin Aleksiêiev (cujo nome artístico era Stanislavski) (1863-1938) e por Vladimir Niemiróvitch-Dântchenko (1858- 1943). Toda sua documentação, produzida ao longo de 121 anos de atividade, é rica fonte de informações para o pesquisador que pretende se aprofundar nas inúmeras possibilidades investigativas que uma companhia de teatro oferece, desde as técnicas de interpretação e direção até a documentação de administração e a correspondência pessoal entre os membros da companhia. Neste artigo, desejo abordar o que o TAM ofereceu à minha pesquisa sobre trajes de cena nas encenações de Stanislavski, sob as diferentes perspectivas documentais apresentadas por Johanna W. Smit e Viviane Tessitore para arquivos, bibliotecas e museus.
Arquivo e repertório na performance de Rolando Boldrin
Authors: Lucas Pedro Isaias
Published: September 2019

Este artigo analisa a prática performática do ator e contador de causos Rolando Boldrin e sua relação com a prática arquival, a partir do acompanhamento de uma gravação do programa de televisão Sr. Brasil da TV Cultura, colocando em perspectiva a observação de fatos relacionados à formação desse ator decano. O texto também sugere a influência da utilização de métodos da cartografia na observação da performance de Boldrin e na produção de dados realizada pelo autor.
A Comédia Cearense – O compromisso com a memória
Authors: Gotelip Paula
Published: September 2019

Este trabalho apresenta o compromisso do grupo Comédia Cearense com o seu acervo e a preocupação com a catalogação e com a publicação de seus trabalhos. A Comédia Cearense foi fundada em 1957 e desde então mantém suas atividades de forma ininterrupta, tanto no teatro adulto quanto no infantil. Ao compartilhar a história do grupo e seus arquivos, descrevem-se marcos do teatro cearense e brasileiro.
“A State of Conscious and Permanent Visibility”: Sight as an Instrument of Cure and Control at the Worcester State Hospital for the Insane, 1833–1900
Authors: Kearin Madeline Bourque
Published: September 2019

The nineteenth-century lunatic hospital was intended to function as a curative instrument, targeting the mind through the senses. This paper compares the way in which visibility was mobilized in the design of the asylum, drawing upon ideals of nature and domesticity, against its imperfect realization in practice, with a focus on the lived experiences of patients.
Systematic list, geographic distribution and ecological significance of lady beetles (Coleoptera: Coccinellidae) from the West Bank (Central Palestine)
Authors: NAJAJRAH MOHAMMAD H. , SWAILEH KHALID M. , QUMSIYEH MAZIN B.
Published: September 2019

We surveyed and identified species of lady beetles from the West Bank to document their geographic distribution and understand their ecological significance. This study documents the presence of 35 species of Coccinellidae in 19 genera belonging to 10 tribes and 6 subfamilies. Seven species (mostly very rare), out of the 35 documented, are recorded for the first time in the area studied. These are Nephus (Bipunctatus) bipunctatus, N. crucifer, Scymnus (Scymnus) interruptus, S. (Parapullus) abietis, S. (Neopullus) limbatus, S. nigropictus, and S. (Pullus) suturalis. Nephus peyerimhoffi, introduced to Palestine in 1986 and later considered extirpated, is recorded from three localities in this study. The distribution of many species generally correlates with local biogeographical zones. All species recorded during the study feed on agricultural pests such as aphids and scale insects. Previously published accounts have been very limited, and while more remains to be done, this study is currently the most comprehensive in the West Bank.
A taxonomic synopsis of Chrysomydas Wilcox, Papavero & Pimentel (Diptera: Mydidae: Mydinae), with first bionomic records for the genus and description of a new species from Brazil
Authors: CALHAU JULIA , LIMA SHEILA , RAFAEL JOSÉ ALBERTINO , LAMAS CARLOS JOSÉ EINICKER
Published: September 2019

Chrysomydas Wilcox, Papavero & Pimentel, 1989 (Diptera, Mydidae, Mydinae, Stratiomydina), is a poorly known monotypic genus, with the type-species, C. nitidulus (Olivier, 1811), recorded from Brazil, French Guiana, Guyana, and Suriname. The present work aims to provide an updated diagnosis for the genus and type-species, C. nitidulus, along with the description of C. phoenix Calhau & Lamas sp. nov. from the state of Rio de Janeiro, Brazil, based on a male imago and associated pupal exuviae. Additionally, the first bionomic data for the genus are reported, with the rearing of adult C. nitidulus in the laboratory from larvae collected under the decaying trunk of a coconut palm (Cocos nucifera L.) in the state of Amazonas, Brazil. The new species is easily distinguished from C. nitidulus by the predominantly black tergal and scutal setulae, which are golden in the type-species. They also differ by the male genitalia and shape of the proboscis.
Charinus rocamadre (Amblypygi, Charinidae): description of the female, ultrastructure of the male and female gonopods, and mitochondrial DNA sequences
Authors: TORRES RICHARD A. , ARROYO-PÉREZ WENDY , ALVAREZ-GARCIA DEIVYS M.
Published: September 2019

Charinus rocamadre is the only species described and recorded from Colombia. It is know from only one male specimen collected from a cave in the Colombian Caribbean region. Herein, we describe the female of C. rocamadre for the first time, based on several specimens collected from the type locality of this species. We also provide images and describe the ultrastructure of male and female gonopods, as well as provide partial sequences of two mitochondrial genes (COI and 16S rRNA).
Eternity in Time—Time in Eternity: Temporality and the Human Self in the Eschaton
Authors: Tóth Beáta
Published: September 2019

By interviewing four interlocutors (Karl Rahner, Hans Urs von Balthasar, Joseph Ratzinger, Jean-Luc Marion, and indirectly a fifth, Augustine of Hippo), this article attempts to open up the conceptual and imaginative space in which the issue of the temporality of the human self within the eschaton may be dealt with in a more consistent manner. The strengths and weaknesses of these accounts—which at several points may be seen as complementing one another—reveal the need for a complex treatment reconfiguring theological anthropological thought along the lines of this traditionally less developed and yet intriguing question.
The future is queer kids: Queering the homonormative temporalities of same-sex marriage
Authors: Stewart Callum
Published: September 2019

Same-sex marriage is emblematic of a crisis of vision in lesbian, gay, bisexual, trans and gender non-binary, intersex, and queer (LGBTIQ) politics, according to some queer theorists. Through the concept of homonormativity, Duggan insightfully criticizes same-sex marriage politics as spatially privatizing and depoliticizing queer difference. Brown argues, however, that Duggan herself reifies homonormativity. He calls for theorists to imagine the queer potential in non-fixed spatial relations. Given Duggan and Brown’s focus on spatiality, this article approaches queer imaginations beyond homonormativity from a temporal perspective: I ask what transformational potential same-sex marriage holds to queer heteronormative and homonormative temporalities. I argue that same-sex marriage may not only queer the public/private dichotomy, but also subvert the heteronormative temporality of straight time. Straight time produces identities, spaces, and times as fixed, pre-political, and timeless, and is constructed against queer time in which identities, spaces, and times are non-fixed, political, and sociohistorically constructed. By theorizing straight/queer time as politically produced through the reproductive relation between adulthood and Childhood, I repoliticize the temporalities of homonormative and queer imaginaries and recognize children as queer citizens of a queer future. Same-sex marriage may therefore produce two previously untheorized images of queer potential: the Child queered by their parents, and the Child queered by their sexuality.
Potential for limited reinforcing and abuse-related subjective effects of intranasal oxytocin
Authors: Dolan Sean B , Berry Meredith S , Johnson Patrick S , Johnson Matthew W
Published: September 2019

Background:

There has been growing interest in using oxytocin as a pharmacotherapy for psychiatric disorders, including substance use disorder. Limited data exist regarding oxytocin’s reinforcing efficacy, which is a necessary consideration for novel pharmacotherapies, especially in substance-using populations.

Aims:

This study aimed to determine the potential reinforcing effects of intranasally administered oxytocin by assessing behavioral economic demand and subjective effects.

Methods:

Healthy adults ( n = 23) participated in a double-blind, repeated-measures, laboratory study wherein they received intranasal oxytocin (40 IU) or placebo in a randomized order across two sessions. Participants completed drug purchasing tasks at the conclusion of both sessions. Throughout both sessions, subjective and physiological effects were assessed.

Results:

Demand-curve analysis of purchasing tasks revealed greater median purchasing for oxytocin relative to placebo. Physiological and subjective effects did not significantly differ between oxytocin and placebo. However, a nonsignificant trend was observed for moderately greater drug liking for oxytocin relative to placebo. There was a significant, positive correlation between the difference in drug liking (between oxytocin and placebo) and the difference in lowest-price purchasing (between oxytocin and placebo).

Conclusions:

These data suggest the potential for limited reinforcing and abuse-related subjective effects of intranasal oxytocin. Given the small sample, the greater drug liking of oxytocin compared to placebo, and the positive relation between demand and drug liking, it is possible that oxytocin may produce reinforcing effects in some participants. Therefore, additional studies of oxytocin reinforcement are warranted.
Capabilities for recovery-oriented practice in mental health occupational therapy: A thematic analysis of lived experience perspectives
Authors: Arblaster Karen , Mackenzie Lynette , Gill Katherine , Willis Karen , Matthews Lynda
Published: September 2019

Introduction

Recovery in mental health is both a policy imperative and a contested concept with individual and systemic elements. Occupational therapy research and pre-registration education have not engaged in a substantial way with these ideas, raising questions about how well graduates are equipped for real world practice. We aimed to address this gap by developing lived experience informed recovery-oriented capabilities to inform occupational therapy practice and pre-registration curricula.

Method

A participatory qualitative approach guided by a consumer reference group was adopted. In-depth interviews were conducted with 16 mental health consumers, wherever possible with a lived experience co-interviewer. Interviews were audio recorded, transcribed verbatim and analysed using thematic analysis.

Findings

Three core capabilities were developed: knowing, comprising five types of knowledge; doing, focused on three key areas of action in practice; and being/becoming, emphasising the lifelong learning journey of becoming a recovery-oriented practitioner who can ‘be’ in authentic partnerships with consumers to support recovery.

Conclusion

These lived experience-informed capabilities offer new areas of focus for pre-registration education, practice and research. A need to engage with systemic factors, build students’ capacity for critical thinking about power and structural inequality, and integration of knowledge frameworks through participatory research is suggested.
Complete kinematic calibration of a 6-RRRPRR parallel kinematic machine based on the optimal measurement configurations
Authors: Han Chunyang , Yu Yang , Xu Zhenbang , Wang Xiaoming , Yu Peng , Zhou Xiaoqin
Published: September 2019

This paper presents a kinematic calibration of a 6-RRRPRR parallel kinematic mechanism with offset RR-joints that would be applied in space positioning field. In order to ensure highly accurate and highly effective calibration process, the complete error model, which contains offset universal joint errors, is established by differentiating inverse kinematic model. A calibration simulation comparison with non-complete error model shows that offset universal joint errors are crucial to improve the calibration accuracy. Using the error model, an optimal calibration configuration selection algorithm is developed to determine the least number of measurement configurations as well as the optimal selection of these configurations from the feasible configuration set. To verify the effectiveness of kinematic calibration, a simulation and experiment were performed. The results show that the developed approach can effectively improve accuracy of a parallel kinematic mechanism with relatively low number of calibration configurations.
Book review: Sejal Vora, The Power of Data Storytelling
Authors: Aeron Prageet
Published: September 2019

Sejal Vora, The Power of Data Storytelling, 2019, New Delhi: SAGE Publications, 248 pp., ₹495 (paperback). ISBN: 9789353282905.
Impact of Environmental Decentralization on Regional Green Development
Authors: Zou Xuan , Lei Can , Gao Keying , Hu Chun
Published: September 2019

Having a reasonable environmental management system is key to achieve regional green development. This article integrates environmental decentralization into an environmental/economic analytical framework, introducing a fiscal decentralization indicator to explore the mechanism of environmental decentralization and regional green development, and then tests this concept using Chinese provincial penal data. The results show that the spillover effect of green development is significant: Improving regional green development will promote green development in neighboring regions. At the national level, different categories of environmental decentralization have different effects, and these can also affect green development through both direct and indirect paths. There is also a positive interaction mechanism between these two variables. Moreover, the interaction between environmental and fiscal decentralization has a negative effect on regional green development, with the impact varying across regions. These findings play an important role in green development, industrial transformation, and advancement, especially in China.
Complexity and mission computability of adaptive computing systems
Authors: Dasari Venkat R , Im Mee Seong , Geerhart Billy
Published: September 2019

There is a subset of computational problems that existing algorithms may not complete due to a lack of adequate computational resources on tactical edge computing platforms. Although this subset is computable in polynomial time, many polynomial problems are not computable in mission time. Here, we define a subclass of deterministic polynomial time complexity called mission class, wherein the computations must complete in mission time. By focusing on this subclass of languages in the context of successful military applications, we discuss their computational and network constraints. We investigate feasible (non)linear models that will minimize energy and maximize memory, efficiency, and computational power, and also provide an approximate solution obtained within a pre-determined length of computation time using limited resources so that an optimal solution to a language could be determined.
Autistic People Do Enhance Their Selves
Authors: Gernsbacher Morton Ann , Stevenson Jennifer L. , Dern Sebastian
Published: September 2019

We investigated whether autistic people are less prone to self-enhance (i.e., portray themselves in socially desirable ways). Autistic ( N = 130) and non-autistic ( N = 130) participants first responded to social desirability items using the standard instruction to endorse each item as true or false about themselves. Then, all participants read an explanation of what social desirability items measure before responding again to the social desirability items. Self-enhancement was operationalized as participants endorsing more social desirability items before learning the explanation than after. All participants endorsed significantly more social desirability items before learning the explanation than after, F subjects(1, 258) = 57.73, p < .001, [Formula: see text] = .183; F items(1, 34) = 43.04, p < .001, [Formula: see text] = .559). However, autistic and non-autistic participants did not significantly differ in how many items they endorsed, either before or after reading the explanation, indicating that autistic people are as susceptible to social desirability and self-enhancement as non-autistic people are. Our results challenge the claim that autistic people are immune to reputation management.
Electrocardiographic recognition of life-threatening hyperkalaemia: the hyperkalaemic Brugada sign
Authors: McNeill Holly , Isles Chris
Published: September 2019

Lesson

Consider life-threatening hyperkalaemia if the ECG shows high take-off with coved ST segment elevation and negative T wave in lead V1 superimposed on other ECG signs of hyperkalaemia and treat with calcium gluconate while waiting for blood chemistry results.
Structural brain characteristics in treatment-resistant depression: review of magnetic resonance imaging studies
Authors: Klok Margit Philomène C. , van Eijndhoven Philip. F. , Argyelan Miklos , Schene Aart H. , Tendolkar Indira
Published: September 2019

Background

Major depressive disorder (MDD) has been related to structural brain characteristics that are correlated with the severity of disease. However, the correlation of these structural changes is less well clarified in treatment-resistant depression (TRD).

Aims

To summarise the existing literature on structural brain characteristics in TRD to create an overview of known abnormalities of the brain in patients with MDD, to form hypotheses about the absence or existence of a common pathophysiology of MDD and TRD.

Method

A systematic search of PubMed and the Cochrane Library for studies published between 1998 and August of 2016 investigating structural brain changes in patients with TRD compared with healthy controls or patients with MDD.

Results

Fourteen articles are included in this review. Lower grey matter volume (GMV) in the anterior cingulate cortex, right cerebellum, caudate nucleus, superior/medial frontal gyrus and hippocampus does not seem to differentiate TRD from milder forms of MDD. However, lower GMV in the putamen, inferior frontal gyrus, precentral gyrus, angular- and post-central gyri together with specific mainly parietal white matter tract changes seem to be more specific structural characteristics of TRD.

Conclusions

The currently available data on structural brain changes in patients with TRD compared with milder forms of MDD and healthy controls cannot sufficiently distinguish between a ‘shared continuum hypothesis’ and a ‘different entity hypothesis’. Our review clearly suggests that although there is some overlap in affected brain regions between milder forms of MDD and TRD, TRD also comes with specific alterations in mainly the putamen and parietal white matter tracts.

Declaration of interest

None.
Spz/Toll-6 signal guides organotropic metastasis in Drosophila
Authors: Mishra-Gorur Ketu , Li Daming , Ma Xianjue , Yarman Yanki , Xue Lei , Xu Tian
Published: September 2019

Targeted cell migration plays important roles in developmental biology and disease processes, including in metastasis. Drosophila tumors exhibit traits characteristic of human cancers, providing a powerful model to study developmental and cancer biology. We now find that cells derived from Drosophila eye-disc tumors also display organ-specific metastasis, invading receptive organs but not wing disc. Toll receptors are known to affect innate immunity and the tumor inflammatory microenvironment by modulating the NF-κB pathway. Our RNA interference (RNAi) screen and genetic analyses show that Toll-6 is required for migration and invasion of the tumor cells. Further, receptive organs express Toll ligands [Spätzle (Spz) family molecules], and ectopic Spz expression renders the wing disc receptive to metastasis. Finally, Toll-6 promotes metastasis by activating JNK signaling, a key regulator of cell migration. Hence, we report Toll-6 and Spz as a new pair of guidance molecules mediating organ-specific metastatic behavior and highlight a novel signaling mechanism for Toll-family receptors.