bluuebunny/crossref_metadata_2025 huggingface dataset:
Cytotoxicity and Genotoxicity of Ceria Nanoparticles on Different Cell Lines in Vitro
Authors: De Marzi Laura , Monaco Antonina , De Lapuente Joaquin , Ramos David , Borras Miquel , Di Gioacchino Mario , Santucci Sandro , Poma Anna
Published: February 2013

Owing to their radical scavenging and UV-filtering properties, ceria nanoparticles (CeO2-NPs) are currently used for various applications, including as catalysts in diesel particulate filters. Because of their ability to filter UV light, CeO2-NPs have garnered significant interest in the medical field and, consequently, are poised for use in various applications. The aim of this work was to investigate the effects of short-term (24 h) and long-term (10 days) CeO2-NP exposure to A549, CaCo2 and HepG2 cell lines. Cytotoxicity assays tested CeO2-NPs over a concentration range of 0.5 μg/mL to 5000 μg/mL, whereas genotoxicity assays tested CeO2-NPs over a concentration range of 0.5 μg/mL to 5000 μg/mL. In vitro assays showed almost no short-term exposure toxicity on any of the tested cell lines. Conversely, long-term CeO2-NP exposure proved toxic for all tested cell lines. NP genotoxicity was detectable even at 24-h exposure. HepG2 was the most sensitive cell line overall; however, the A549 line was most sensitive to the lowest concentration tested. Moreover, the results confirmed the ceria nanoparticles’ capacity to protect cells when they are exposed to well-known oxidants such as H2O2. A Comet assay was performed in the presence of both H2O2 and CeO2-NPs. When hydrogen peroxide was maintained at 25 μM, NPs at 0.5 μg/mL, 50 μg/mL, and 500 μg/mL protected the cells from oxidative damage. Thus, the NPs prevented H2O2-induced genotoxic damage.
Amplification Target ADRM1: Role as an Oncogene and Therapeutic Target for Ovarian Cancer
Authors: Fejzo Marlena , Anderson Lee , Von Euw Erika , Kalous Ondrej , Avliyakulov Nuraly , Haykinson Michael , Konecny Gottfried , Finn Richard , Slamon Dennis
Published: February 2013

Approximately 25,000 ovarian cancers are diagnosed in the U.S. annually, and 75% are in the advanced stage and largely incurable. There is critical need for early detection tools and novel treatments. Proteasomal ubiquitin receptor ADRM1 is a protein that is encoded by the ADRM1 gene. Recently, we showed that among 20q13-amplified genes in ovarian cancer, ADRM1 overexpression was the most highly correlated with amplification and was significantly upregulated with respect to stage, recurrence, and metastasis. Its overexpression correlated significantly with shorter time to recurrence and overall survival. Array-CGH and microarray expression of ovarian cancer cell lines provided evidence consistent with primary tumor data that ADRM1 is a 20q13 amplification target. Herein, we confirm the ADRM1 amplicon in a second ovarian cancer cohort and define a minimally amplified region of 262 KB encompassing seven genes. Additionally, using RNAi knock-down of ADRM1 in naturally amplified cell line OAW42 and overexpression of ADRM1 via transfection in ES2, we show that (1) ADRM1 overexpression increases proliferation, migration, and growth in soft agar, and (2) knock-down of ADRM1 results in apoptosis. Proteomic analysis of cells with ADRM1 knock-down reveals dysregulation of proteins including CDK-activating kinase assembly factor MAT1. Taken together, the results indicate that amplified ADRM1 is involved in cell proliferation, migration and survival in ovarian cancer cells, supporting a role as an oncogene and novel therapeutic target for ovarian cancer.
Analysis of Expressed Sequence Tags from Chinese Bayberry Fruit (Myrica rubra Sieb. and Zucc.) at Different Ripening Stages and Their Association with Fruit Quality Development
Authors: Zhu Changqing , Feng Chao , Li Xian , Xu Changjie , Sun Chongde , Chen Kunsong
Published: February 2013

A total of 2000 EST sequences were produced from cDNA libraries generated from Chinese bayberry fruit (Myrica rubra Sieb. and Zucc. cv. “Biqi”) at four different ripening stages. After cluster and assembly analysis of the datasets by UniProt, 395 unigenes were identified, and their presumed functions were assigned to 14 putative cellular roles. Furthermore, a sequence BLAST was done for the top ten highly expressed genes in the ESTs, and genes associated with disease/defense and anthocyanin accumulation were analyzed. Gene-encoding elements associated with ethylene biosynthesis and signal transductions, in addition to other senescence-regulating proteins, as well as those associated with quality formation during fruit ripening, were also identified. Their possible roles were subsequently discussed.
Optimization of the Preparation of Fish Protein Anti-Obesity Hydrolysates Using Response Surface Methodology
Authors: Liu Liyuan , Wang Yanping , Peng Chen , Wang Jinju
Published: February 2013

The enzymatic condition for producing the anti-obesity hydrolysates from fish water-soluble protein was optimized with the aid of response surface methodology, which also derived a statistical model for experimental validation. Compared with neutral protease, papain and protamex, the porcine pancreas lipase inhibitory rate of hydrolysates from fish water-soluble protein was higher with alkaline protease. Results showed that the model terms were significant, the terms of lack of fit were not significant, and the optimal conditions for the hydrolysis by alkaline protease were initial pH 11, temperature 39 °C, enzyme dosage 122 U/mL and 10 h of hydrolysis time. Under these conditions, the porcine pancreas lipase and the α-amylase inhibitory rate could reach 53.04% ± 1.32% and 20.03 ± 0.89%, while predicted value were 54.63% ± 1.75%, 21.22% ± 0.70%, respectively. In addition, Lineweaver-Burk plots showed noncompetitive inhibition. The Ki value calculated was 84.13 mg/mL. These results demonstrated that fish water-soluble protein could be used for obtaining anti-obesity hydrolysates.
Silica-Supported Polyphosphoric Acid in the Synthesis of 4-Substituted Tetrahydroisoquinoline Derivatives
Authors: Manolov Stanimir , Nikolova Stoyanka , Ivanov Iliyan
Published: February 2013

We report herein an application of an α-amidoalkylation reaction, as an alternative efficient synthesis of 4-aryl- and 4-methyl-1,2,3,4-tetrahydroisoquinoline derivatives. The amides required for this purpose would result from reaction of aminoacetaldehyde dimethylacetal with different substituted benzenes in polyphosphoric acid, followed by acylation of the obtained amines with different acid chlorides or sulfochlorides. We compared the cyclisation step using conventional (milieu of acetic-trifluoracetic acid = 4:1) and solid supported reagents (SiO2/PPA), as recovered, regenerated and reused without loss of its activity catalyst. We found that in comparison to conventional methods, the yields of the reaction are greater and the reaction time is shorter.
A Pyrene- and Phosphonate-Containing Fluorescent Probe as Guest Molecule in a Host Polymer Matrix
Authors: Villemin Elise , Elias Benjamin , Devillers Michel , Marchand-Brynaert Jacqueline
Published: February 2013

New host-guest materials have been prepared by incorporation of a home-made organic probe displaying a pyrene motif and a phosphonate function into a regular amphiphilic copolymer. Using powder X-Ray diffraction, photoluminescence and FT-IR spectroscopy, we have been able to study the non-covalent interactions between the host matrix and the guest molecule in the solid state. Interestingly, we have shown that the matrix directs the guest spatial localization and alters its properties. Thanks to the comparison of pyrene vs. N-pyrenylmaleimide derivatives, the influence of the chemical nature of the guest molecules on the non-covalent interactions with the host have been studied. In addition, using polyethylene glycol as a reference host, we have been able to evidence a true matrix effect within our new insertion materials. The phosphonated guest molecule appears to be a novel probe targeting the hydrophilic domain of the host copolymer.
Design, Synthesis and Hepatoprotective Activity of Analogs of the Natural Product Goodyeroside A
Authors: Zhang Feng , Han Bei , Li Peng , Lin Ziyun , Yin Dali , Li Yan , Zhong Jialiang , Huang Haihong
Published: February 2013

Goodyeroside A, a natural product isolated from the Goodyera species, possesses significant hepatoprotective activity and has a novel skeleton not previously observed in other synthetic drugs used for the treatment of hepatitis. Herein, we report a highly stereoselective synthesis of goodyeroside A and related analogs with varying substituents at the α position of the carbonyl group to explore the structure-activity relationships of goodyeroside A. The absolute configuration of analog 5d was confirmed by single crystal X-ray analysis. The results from in vitro and in vivo studies indicate that 5a, the fully acetylated compound of goodyeroside A, is worthy of further investigation as a lead to identify novel hepatoprotective agents.
Euphorbia formosana Root Extract Induces Apoptosis by Caspase-Dependent Cell Death via Fas and Mitochondrial Pathway in THP-1 Human Leukemic Cells
Authors: Hsieh Yi-Jen , Chang Chih-Jui , Wan Chin-Feng , Chen Chin-Piao , Chiu Yi-Han , Leu Yann-Lii , Peng Kou-Cheng
Published: February 2013

Acute myeloid leukemia (AML), a very rare type of cancer, generally affects patients over 50 years old. While clinical drugs to treat advanced stages of AML exist, the disease becomes increasingly resistant to therapies. Euphorbia formosana Hayata (EF) is a native Taiwanese medicinal plant used to treat rheumatism, liver cirrhosis, herpes zoster, scabies, and photoaging, along with tumor suppression. However, the mechanisms by which it suppresses tumors have not been explored. Here, we provide molecular evidence that a hot-water extract of Euphorbia formosana (EFW) selectively inhibited the growth of human leukemic cancer cells more than other solid human cancer cell lines. Most importantly, the plant extract had limited toxicity toward healthy peripheral blood mononuclear cells (PBMCs). After THP-1 leukemic cells were treated with 50–100 µg/mL EFW for one day, the S phase DNA content of the cells increased, while treatment with 200–400 µg/mL caused the cells to accumulate in the G0/G1 phase. Notably, EFW did not affect A-549 lung cancer cells. The effectiveness of EFW against THP-1 cells may be through caspase-dependent apoptosis in leukemic cells, which is mediated through the Fas and mitochondrial pathways. The potent antileukemic activity of EFW in vitro warrants further investigation of this plant to treat leukemias and other malignancies.
3D LIDAR-Camera Extrinsic Calibration Using an Arbitrary Trihedron
Authors: Gong Xiaojin , Lin Ying , Liu Jilin
Published: February 2013

This paper presents a novel way to address the extrinsic calibration problem for a system composed of a 3D LIDAR and a camera. The relative transformation between the two sensors is calibrated via a nonlinear least squares (NLS) problem, which is formulated in terms of the geometric constraints associated with a trihedral object. Precise initial estimates of NLS are obtained by dividing it into two sub-problems that are solved individually. With the precise initializations, the calibration parameters are further refined by iteratively optimizing the NLS problem. The algorithm is validated on both simulated and real data, as well as a 3D reconstruction application. Moreover, since the trihedral target used for calibration can be either orthogonal or not, it is very often present in structured environments, making the calibration convenient.
The Regional Index of Sustainable Economic Welfare for Flanders, Belgium
Authors: Bleys Brent
Published: February 2013

In this paper, the regional Index of Sustainable Economic Welfare (ISEW) is compiled for Flanders for the period 1990–2009. The ISEW is a measure of economic welfare in that it measures the contribution of a country’s or region’s economy to the overall level of well-being of its citizens. It does so by comparing the benefits and the costs of economic activities rather than simply looking at the market value of all final goods and services produced in an economy (Gross Domestic Product-GDP). The ISEW for Flanders shows that the per capita level of sustainable economic welfare in the region decreased between 1990 and 2009. The drop in the ISEW/capita is caused by a deterioration of the net international investment position of Belgium (which is divided over the different regions in the country on a per capita basis) and by an increase in the income inequalities in Flanders. To a lesser extent, the increase of the environmental costs (climate change and the use of non-renewable energy resources) also contributed to the decrease in the ISEW per capita. In the last four years of the study period, the level of sustainable economic welfare in the Flemish region started to rise again, even in 2008 and 2009 during the economic recession.
An Integrated Model Based on a Hierarchical Indices System for Monitoring and Evaluating Urban Sustainability
Authors: Shen Li , Kyllo Jared , Guo Xulin
Published: February 2013

Over 50% of world’s population presently resides in cities, and this number is expected to rise to ~70% by 2050. Increasing urbanization problems including population growth, urban sprawl, land use change, unemployment, and environmental degradation, have markedly impacted urban residents’ Quality of Life (QOL). Therefore, urban sustainability and its measurement have gained increasing attention from administrators, urban planners, and scientific communities throughout the world with respect to improving urban development and human well-being. The widely accepted definition of urban sustainability emphasizes the balancing development of three primary domains (urban economy, society, and environment). This article attempts to improve the aforementioned definition of urban sustainability by incorporating a human well-being dimension. Major problems identified in existing urban sustainability indicator (USI) models include a weak integration of potential indicators, poor measurement and quantification, and insufficient spatial-temporal analysis. To tackle these challenges an integrated USI model based on a hierarchical indices system was established for monitoring and evaluating urban sustainability. This model can be performed by quantifying indicators using both traditional statistical approaches and advanced geomatic techniques based on satellite imagery and census data, which aims to provide a theoretical basis for a comprehensive assessment of urban sustainability from a spatial-temporal perspective.
Excess Female Siblings and Male Fetal Loss in Families with Systemic Lupus Erythematosus
Authors: Aggarwal Rachna , Sestak Andrea L. , Chakravarty Eliza F. , Harley John B. , Scofield R. Hal
Published: February 2013

Objective.

Systemic lupus erythematosus (SLE) occurs more frequently among women than men. We aimed to determine whether the male-female ratio in SLE families is different from what would be expected by chance, and whether excess male fetal loss is found.

Methods.

All patients with SLE met the revised American College of Rheumatology classification criteria, while unaffected subjects were shown not to satisfy these same criteria. Putative family relationships were confirmed by genetic testing. Pregnancy history was obtained from all subjects, including unrelated control women. Adjusted Wald binomial confidence intervals were calculated for ratio of boys to girls in families and compared to the expected ratio of 1.06.

Results.

There were 2579 subjects with SLE, with 6056 siblings. Considering all subjects, we found 3201 boys and 5434 girls (ratio 0.59, of 95% CI 0.576–0.602). Considering only the SLE-unaffected siblings, there were 2919 boys and 3137 girls (ratio 0.93, 95% CI 0.92–0.94). In both cases, the ratio of males to females was statistically different from the known birth rate. Among patients with SLE as well as among their sisters and mothers, there was an excess of male fetal loss compared to the controls.

Conclusion.

Siblings of patients with SLE are more likely than expected to be girls. This finding may be in part explained by excess male fetal loss, which is found among patients with SLE and their first-degree relatives.
La conception des instrumentations de gestion RH : l'apport du concept de rapport de prescription
Authors: Oiry Ewan
Published: February 2013

Résumé Les usages des instrumentations de gestion font l’objet d’une littérature de plus en plus riche. En revanche, leur processus de conception reste peu analysé. Des travaux très récents proposent toutefois l’idée que la conception d’une instrumentation de gestion correspondrait à un processus de construction d’une chaîne de traductions. Tout en reprenant cette idée, nous soulignons dans cet article l’apport du concept de rapport de prescription. Nous aboutissons ainsi à un cadre d’analyse du processus de construction d’une instrumentation de gestion. Nous montrons les potentialités de ce cadre d’analyse en l’appliquant au cas de la conception d’une instrumentation de gestion des compétences. Dans notre discussion, ces éléments conceptuels et ces résultats empiriques nous permettent d’identifier des perspectives de recherche.
Le conseiller en bilan de compétences du CIBC 33 : un tuteur de résilience pour les personnes en situation d'échec professionnel ?
Authors: Cusin Julien
Published: February 2013

Résumé Dans le contexte économique actuel, la carrière des individus est de plus en plus jalonnée de moments de rupture et de situations d’échecs. Pour autant, même si ces situations-là se banalisent, elles constituent toujours une épreuve sur le plan psychologique, dont l’intensité varie selon le degré de résilience des personnes. Certaines peuvent s’appuyer sur leurs ressorts internes pour surmonter le choc subi, là où d’autres auront besoin d’un soutien et d’un encouragement externes appropriés. En l’occurrence, dans cette recherche qualitative, nous nous demandons si les conseillers du Centre Interinstitutionnel de Bilans de Compétences de la Gironde (CIBC 33) peuvent faire office de tuteurs de résilience pour des personnes faisant face à une déconvenue dans leur parcours professionnel. Pour traiter cette question, nous adaptons la grille théorique de Bégin et Chabaud (2010), qui nous sert de canevas pour coder nos entretiens et structurer les données recueillies. Nous étudions ainsi le rôle joué par les consultants en matière d’absorption du choc, de reconstruction d’un plan de carrière et d’appropriation de l’expérience vécue. Nous arrivons notamment à la conclusion que le conseiller aide incontestablement le bénéficiaire à reprendre confiance en lui et à élaborer une feuille de route grâce au travail de formalisation des compétences. En revanche, il a plus de mal à favoriser un processus d’apprentissage par l’échec, en raison de sa posture de neutralité bienveillante et de non jugement. Du fait d’un environnement psychologiquement rassurant et valorisant, l’individu manque ainsi de réflexivité et sombre très souvent dans la victimisation et l’externalisation.
L'interprétation transculturelle des rêves: possibilité, utilité, méthode
Authors: Schurmans Dan
Published: February 2013

Résumé Deux questions sont abordées: d’abord la place du culturel dans l’élaboration du rêve; ensuite, la nature de l’acte d’interpréter et la position de l’interprétateur. Que le rêve soit une production de l’Inconscient, ou qu’il soit un message de l’au-delà, il émane d’une instance extérieure à soi. La conception qui fait du rêve un voyage initiatique est particulièrement intéressante, en ce qu’elle met en scène le Soi du rêveur face à une altérité qu’il découvre et qui l’enseigne. Dans chacun de ces cas, le rêve n’échappe pas à une mise en forme culturelle. (Si l’Inconscient est le discours de l’Autre, la culture en est la langue). Les psychanalystes, qui ont toujours admis cela, font du contenu du rêve une élaboration personnelle: cet aspect n’est pas nié par les savoirs traditionnels. La principale différence réside dans la direction donnée à l’acte d’interprétation, qui va, dans un cas, du culturel vers l’individuel conçu comme spécifique et déterminant, dans l’autre cas de l’individuel anecdotique au culturel significatif. L’auteur affirme que le rêve lui-même est un processus intentionnel informé par la culture, et que l’interprétation, pour être thérapeutique, doit en tenir compte. Une vignette clinique illustre cette thèse.
Sentir et dire la force vitale: le rêve et l'oracle médiumnique en milieu yaka
Authors: Devisch René
Published: February 2013

Résumé Au regard de la culture Yaka à Kinshasa et au Congo du Sud-Ouest, la force vitale d’un membre vivant ou décédé de la famille peut se manifester à d’autres membres dans le rêve et au devin médiumnique dans l’oracle divinatoire. La force vitale constitue une fonction liminale entre les passions et la réflexion, l’individu et les siens (les ascendants et les descendants), le somato-psychique et le socioculturel, l’être humain en tant que microcosme et les virtualités du macrocosme, la quête des « origines » (des objets originaires) et les métaphores politiques, sociales, professionnelles, religieuses fondatrices du milieu relationnel, de la profession, de l’investissement défensif, ou du traumatisme. La mort (l’existence dans l’outre-tombe), le sommeil, le rêve et l’oracle divinatoire sont apparentés comme des manifestations, sous des modalités humorales, de la force vitale au niveau du cœur et du foie. Tout comme la force vitale relie vivants et morts, les Yaka perçoivent le rêve et ses thèmes comme un mode bien réel et commun de communication et de gestion de l’insertion de l’individu dans le monde ainsi que le groupe et son histoire.
Dieu qu'elle devait être seule! Histoire d'une brève rencontre entre deux mondes
Authors: Pierre Danièle
Published: February 2013

Résumé L’auteur expose le cas clinique d’une jeune femme congolaise immigrée en Belgique. Envisagées comme autant d’élaborations secondaires des motifs inconscients, les accusations de sorcellerie permettent d’accéder – notamment dans les rêves – au cœur-même de la problématique œdipienne.
Les processus de guérison chez l'enfant et l'adolescent: étude pluridisciplinaire. Objectifs et méthode
Authors: Pradère Jérôme , Taïeb Olivier
Published: February 2013

Résumé Cet article décrit les objectifs et la méthodologie d’une recherche pluridisciplinaire sur les processus de guérison actuellement en cours de réalisation. La drépanocytose est une maladie hématologique chronique, héréditaire, caractérisée par un début précoce dans l’enfance, par ses aspects transgénérationnels et transculturels. La greffe de moelle osseuse est actuellement le seul traitement potentiellement curateur: le taux de « guérison » est de 85%. La greffe de moelle osseuse dans la drépanocytose fournit donc un modèle exemplaire d’étude des processus de guérison, dans leur dimension individuelle, familiale, sociale et culturelle.
Le sujet amoureux
Authors: Lauru Didier
Published: February 2013

Résumé Sentiment méconnu et chanté par les poètes, l’expérience amoureuse est ineffable douloureuse et merveilleuse, unique et pourtant répétant l’ombre de nous-mêmes dans notre quête de l’autre toujours à jamais perdu. C’est au travers de cette recherche de l’autre à jamais perdu que le procès de la subjectivation avance. Nous le retrouvons dans le transfert sous un jour particulier. Les adultes renouent avec leur adolescence par le biais d’expériences amoureuses, qui peuvent saisir le sujet à tout âge !
Sur les traces d'un objet insaisissable
Authors: Journet-Diallo Odile
Published: February 2013

Résumé Si l’ethnologue ne peut rien dire de l’affect éprouvé par l’« autre », il peut toutefois tenter d’en saisir les traces dans les matériaux (dispositifs institutionnels, littérature orale, témoignages, formes de jalousie) dont il dispose. C’est ce que tente cet article en examinant quelques cas de figure situés dans le contexte de deux types de sociétés africaines, les unes marquées par un fort taux de polygynie et la prévalence des tractations familiales sur les sentiments éprouvés par les intéressés, une autre par la prise en compte initiale de ces sentiments, mais leur dénigrement lorsqu’ils ne sont plus congruents avec les objectifs du mariage. Le détour par une autre catégorie de sentiment – ceux qu’une mère peut éprouver pour son enfant – et la façon dont il est traité, permet de mettre en relief le statut du sentiment amoureux là même où il semblerait pris en compte par les institutions. Dans tous les cas évoqués, « aimer dans son cœur » est l’ultime trésor qui résiste aux contraintes sociales.
Initiation sentimentale et sexuelle chez les Touaregs du Mali
Authors: Figueiredo-Biton Cristina
Published: February 2013

Résumé Cet article présente les enseignements sur le corps et les émotions donnés aux jeunes Touaregs au moment de leur puberté. Les filles, avant leur menstruation, sont préparées à comprendre le fonctionnement du corps féminin et à savoir que, dès les premières pertes de sang, elles devront se soumettre à une autodiscipline qui les protègera de toute perturbation affective pour ne pas perturber leur cycle biologique. Dès lors, elles se rendront à plusieurs reprises chez des femmes savantes afin de recevoir plusieurs degrés d’enseignements. Les garçons, pour qui il est plus difficile de déterminer le début précis de la puberté, reçoivent une éducation sexuelle moins formelle. Pour les deux sexes, l’acquisition d’un certain savoir est honorée par l’attribution d’un voile de tête qui permet aux filles comme aux garçons de devenir l’objet d’un nouveau regard.
Épreuves d'amour en Mauritanie
Authors: Fortier Corinne
Published: February 2013

Résumé Les hommes nobles de la société maure de Mauritanie, société de pasteurs nomades, connaissaient jusqu’à peu un code de galanterie inspiré de la chevalerie arabe qui se manifestait en particulier dans le rapport aux femmes, et surtout à l’occasion de relations amoureuses. L’homme faisait don de soi à sa belle par l’entremise de poèmes inspirés par sa muse, de visites nocturnes semées de mille périls, et de divers cadeaux somptueux. La rivalité qui l’opposait à d’autres jeunes hommes dans la conquête d’une femme, ainsi que le courage, la ténacité et la générosité dont il devait faire montre constituaient autant d’épreuves initiatiques à surmonter. La voie de l’amour est aussi celle de la masculinisation, et les preuves d’amour, des épreuves de virilité. La femme pouvait répondre ou non, et cela de différentes façons, à cette dépense amoureuse où les cadeaux jouaient une place centrale. Elle était de toute façon toujours au départ objet du désir de l’homme, désir que celui-ci apprenait à discipliner à travers cette cour même. L’activité féminine se bornait à aiguiser le désir masculin par sa beauté, son discours relevé, ses mimiques sensuelles et ses refus mesurés, s’attachant ainsi à défendre son image de femme pudique.
Les enfants et les jeunes face à la pauvreté urbaine en Afrique
Authors: Djakaridja Koné
Published: February 2013

Résumé Dans les rues des villes africaines, face à la pauvreté de nombreux enfants et jeunes, inventent quotidiennement, au détriment des activités éducatives fondamentales, des solutions originales pour survivre, dans l’indifférence générale et parfois l’exploitation organisée. Si la plupart de ces jeunes de la rue restent encore en lien avec leurs familles et continuent d’en être influencés, un nombre de plus en plus important, en rupture, échappent à tout contrôle adulte et vivent dans la rue. Ces situations confèrent à ces jeunes un rôle moteur dans les changements accélérés de l’espace urbain et la construction de nouvelles cultures urbaines « métissées » à la place des cultures « ethniques » villageoises en voie de disparition. Cela a rendu caduques les modes classiques d’encadrement et a invité les intervenants socio-éducatifs en milieu urbain à changer leurs regards et leurs approches.
A propos de L'Éducation sentimentale de Flaubert, écriture et réminiscence
Authors: Pynson Pascale
Published: February 2013

Résumé L’éducation sentimentale, occupe une place centrale dans l’œuvre de Flaubert. Le texte est traversé par des réminiscences que Flaubert prête à son héros, Frédéric Moreau, et qui sont autant de retours du souvenir de sa première rencontre amoureuse. L’apparition-disparition dans leur évidence visuelle sont une des caractéristiques dans le roman d’un mode de progression dans l’apprentissage de Frédéric de sa vie d’adulte, tempéré par la certitude pour Flaubert que l’expérience originaire de l’amour ne pourrait que se répéter au travers de figures féminines dont on perçoit la dimension maternelle. Trois textes de jeunesse constituent la matrice du roman. A la lueur des études de Freud sur la vie sexuelle et les « constructions dans l’analyse », une relecture nous éclaire sur le travail du souvenir et d’une écriture qui se révèle comme une auto-analyse.
La “casa oval” del Areópago y los Medóntidas en el origen de la polis de Atenas
Authors: Valdés Guía Miriam
Published: February 2013

El edificio elíptico encontrado al norte del Areópago de época geométrica, reconvertido en depósito votivo en el siglo VII, sirve para reflexionar sobre el proceso de formación de la polis y el tránsito de la basileia a otras formas de gobierno aristocráticas y colegiadas en los orígenes de Atenas, en relación con determinados cultos que se convierten en referentes de toda la comunidad.
Wein, Weib und Gesang. A propósito de tres apliques de bronce arcaicos entre la Península Ibérica y Baleares
Authors: Bardelli Giacomo , Graells i Fabregat Raimon
Published: February 2013

El nuevo estudio de tres figuras de bronce de tipo etrusco e itálico permite reconsiderar el dossier de la vajilla metálica importada en el Mediterráneo occidental. En primer lugar, una completa descripción de cada figura autoriza consideraciones acerca de la procedencia así como su correcta función original.
En segundo lugar, se ofrece una revisión de la vajilla metálica etrusca e itálica recuperada en la Península en la que se incluyen nuevos hallazgos. Este catálogo organiza los distintos tipos de importaciones de manera exhaustiva.
Finalmente, se contextualizan los tres fragmentos examinados en la primera parte, destacándose respecto a las importaciones estándar. Como resultado, para dos de las tres piezas, la procedencia de contextos arqueológicos del mediterráneo occidental es difícil de aceptar.
El Castellet de Banyoles (Tivissa): Una ciudad ibérica en el curso inferior del río Ebro
Authors: Sanmartí Joan , Asensio David , Teresa Miró M.ª , Jornet Rafael
Published: February 2013

Aunque es un yacimiento recurrentemente mencionado en la bibliografía especializada, hasta hace pocos años el Castellet de Banyoles sólo era realmente conocido por los hallazgos monetarios y de elementos suntuarios de carácter ritual, a parte de las torres pentagonales de tipo helenístico que flanquean su puerta. Los trabajos realizados desde 1998 han permitido precisar la datación del primer asentamiento entre el último tercio del siglo III a.C. y principios del II a.C., y han mostrado la existencia en ese momento de una muralla de compartimentos de tipo púnico. También han traído a luz un extenso sector de hábitat —que probablemente corresponde a un grupo gentilicio—, con casas de distintos tipos y tamaños, y un posible santuario. Con una superficie de 4,5 ha, se trata de una pequeña ciudad que agrupaba toda la población de la hoya de Móra, siguiendo un modelo mononuclear inédito en el mundo ibérico septentrional, y que tal vez se explique por razones estratégicas en un contexto histórico convulso a causa de la expansión bárquida y la segunda guerra púnica.
Sobre cerámicas Helenísticas en Iberia / Hispania. Significado y funcionalidad
Authors: Pérez Ballester José
Published: February 2013

En este trabajo haremos un recorrido cronológico y tipológico estudiando la iconografía que aparece en las cerámicas helenísticas importadas del Mediterráneo Central y Oriental entre los siglos III y II a.C. en la Hispania Citerior, en especial de Cartagena. Analizaremos su funcionalidad en los lugares de origen, y con ayuda de los contextos hispanos concluiremos si su presencia aquí es consecuencia de una dinámica comercial determinada, o responde a una preferencia decorativa, de gusto o moda; o bien si las imágenes son significantes ligados a usos rituales o conviviales concretos, públicos o privados, por parte del habitante local que los adquiere y utiliza.
Las imágenes como un modo de acción: las estatuas de guerreros castreños
Authors: Rodríguez-Corral Javier
Published: February 2013

La identidad social es siempre experimentada y representada en contextos específicos. Al tener un carácter procesual, se necesitan puntos materiales específicos de referencia en la forma de paisajes, lugares, artefactos y personas. Centrándose en las estatuas de guerreros castreños, este artículo reflexiona sobre el papel de estas imágenes y examina la importancia de estas formas materiales como un medio crucial a través del cual la identidad y sociabilidad son creadas, contestadas y resueltas.
La Tumba del Elefante de la Necrópolis Romana de Carmona. Una revisión necesaria desde la Arqueología de la Arquitectura y la Arqueoastronomía
Authors: Jiménez Hernández Alejandro , Carrasco Gómez Inmaculada
Published: February 2013

Presentamos una revisión de la Tumba del Elefante en la Necrópolis Romana de Carmona (Sevilla) realizada bajo principios metodológicos de la Arqueología de la Arquitectura y la Arqueoastronomía. Los resultados obtenidos muestran que el edificio tuvo varias fases de uso y que fue construido para albergar un mitreo como indican su forma y la simbología derivada del análisis arqueoastronómico de la orientación solar de la ventana.
Análisis arqueomorfológico y dinámica territorial en el Vallés Oriental (Barcelona) de la Protohistoria s. VI-V a.C.) a la alta Edad Media (s. IX-X)
Authors: Flórez Santasusana Marta , Palet Martínez Josep M.
Published: February 2013

La investigación sobre el paisaje en zonas urbanas o periurbanas implica importantes limitaciones metodológicas. En el presente estudio, el trabajo se centra en un llano pre-litoral próximo a la ciudad de Barcelona, el Vallès Oriental, profundamente urbanizado en las últimas dos décadas, hecho que condiciona la recuperación de nuevos datos arqueológicos y la implementación de programas de prospección arqueológica. Asimismo, la particular topografía que presenta el llano, caracterizado por unos relieves suaves, ha obligado a adaptar la metodología del análisis arqueomorfológico a este contexto geográfico.
El artículo presenta los resultados del análisis arqueomorfológico realizado, que han sido cruzados con la documentación histórica y arqueológica para caracterizar —desde una perspectiva diacrónica— la red viaria, la estructuración territorial y la evolución del poblamiento de esta área y, finalmente, determinar las dinámicas del paisaje en época romana. La investigación sobre la morfología del territorio se ha llevado a cabo a partir de un intenso trabajo de fotointerpretación y análisis de la cartografía histórica en entorno SIG, especialmente útil en un paisaje marcado por las importantes trasformaciones del medio rural. Igualmente, los datos generados en los últimos años por la investigación arqueológica han sido revisados de forma detallada, a fin de contribuir a la planificación de las prospecciones arqueológicas y arqueomorfológicas desarrolladas.
Los sellos in planta pedis de las ánforas olearias béticas Dressel 23 (primera mitad siglo V d.C.)
Authors: Berni Millet Piero , Moros Díaz Juan
Published: February 2013

Mucho se ha escrito sobre la producción y consumo de aceite bético en el marco histórico del Alto Imperio romano, pero muy poco se sabe sobre la pervivencia de las ánforas olearias béticas durante el Bajo Imperio. Presentamos el estudio epigráfico y económico de una producción particular de ánforas Dressel 23, bien datada y contextualizada en la primera mitad del siglo V d.C. Se trata de una fuente documental de gran valor para la investigación, porque gracias a ella podemos afirmar, con datos objetivos, que este comercio continuó ejerciendo un liderazgo significativo en una época de gran vitalidad comercial bajo la esfera política y religiosa del cristianismo primitivo.
El uso de la cueva de Arlanpe (Bizkaia) en época tardorromana
Authors: Gutiérrez Cuenca Enrique , Hierro Gárate José Ángel , Ríos Garaizar Joseba , Gárate Maidagan Diego , Gómez Olivencia Asier , Arceredillo Alonso Diego
Published: February 2013

En este trabajo se presentan los materiales arqueológicos tardorromanos (siglo IV d.C.) de la cueva de Arlanpe (Lemoa, Bizkaia). Se trata de fragmentos de terra sigillata y de cerámica común romana, vidrios, objetos metálicos, restos de fauna, etc., que fueron encontrados en el interior de dos fosas excavadas en el suelo de la cavidad. Ambas estructuras son interpretadas como “fosas de ofrendas” y se relacionan con algún tipo de ritual mágico-religioso de origen pagano.
Nuevo miliario de Augusto procedente de Fuenteguinaldo (Salamanca)
Authors: Salinas de Frías Manuel , Palao Vicente Juan José
Published: February 2013

Damos a conocer un nuevo miliario del emperador Augusto hallado en el término municipal de Fuenteguinaldo, en el suroeste de la provincia de Salamanca.
Una inscripción latina relativa a la fundación de Olite (Navarra)
Authors: Velaza Javier
Published: February 2013

Editamos en este trabajo una nueva inscripción latina hallada en Sansomain (NA), que hace referencia a la fundación de Ologite por parte del rey godo Suintila.
Los documentos de idoneidad técnica como potenciales incentivadores de la industrialización de la construcción
Authors: Salas J. , Blázquez A. , Oteiza I. , Monjo J. , Vega L. , Camps I. P.
Published: February 2013

En la primera parte de este trabajo1 se desglosa la incidencia de los elementos funcionales en la edificación, como paso previo para el estudio de dos edificios de viviendas, en los que se ha simulado la aplicación intensiva de sistemas, productos y/o componentes acreditados con DIT, DIT Plus o DITE.

El trabajo concluye destacando que hay una relación directa entre el número de ‘documentos’ (DIT, DIT Plus o DITE) otorgados y la disponibilidad de productos industrializados para la construcción (fachadas, cerramientos interiores, cubiertas…), estimado en un 70% del valor los elementos funcionales de los edificios de viviendas. Así, la relativamente escasa utilización de elementos industrializados (entendido en este caso –a efectos únicamente de este trabajo- como los que cuentan con los ‘documentos’ aludidos) en la construcción de viviendas en España, no puede imputarse a una carencia de elementos, componentes o subsistemas industrializados de mercado.
The argument of Explaining the Normative
Authors: Turner Stephen
Published: February 2013

No disponible
Social science and ‘normative facts’. What's the big deal?
Authors: Noguera José A.
Published: February 2013

No disponible
A Tree-Based Approach for Detecting Redundant Business Rules in Very Large Financial Datasets
Authors: Le-Khac Nhien-An , Markos Sammer , Kechadi Tahar
Published: February 2013

Net Asset Value (NAV) calculation and validation is the principle task of a fund administrator. If the NAV of a fund is calculated incorrectly then there is huge impact on the fund administrator; such as monetary compensation, reputational loss, or loss of business. In general, these companies use the same methodology to calculate the NAV of a fund; however the type of fund in question dictates the set of business rules used to validate this. Today, most Fund Administrators depend heavily on human resources due to the lack of an automated standardized solutions, however due to economic climate and the need for efficiency and costs reduction many banks are now looking for an automated solution with minimal human interaction; i.e., straight through processing (STP). Within the scope of a collaboration project that focuses on building an optimal solution for NAV validation, the authors will present a new approach for detecting correlated business rules and show how they evaluate this approach using real-world financial data.
Closing the Gap between Data Mining and Business Users of Business Intelligence Systems
Authors: Azevedo Ana , Santos Manuel Filipe
Published: February 2013

Since Lunh first used the term Business Intelligence (BI) in 1958, major transformations happened in the field of information systems and technologies, especially in the area of decision support systems. BI systems are widely used in organizations and their importance is recognized. These systems present themselves as essential parts of a complete knowledge of business and an irreplaceable tool in the support to decision making. The dissemination of data mining (DM) tools is increasing in the BI field, as well as the acknowledgment of the relevance of its usage in enterprise BI systems. BI tools are friendly, iterative, and interactive, allowing business users an easy access. The user can manipulate directly data, having the ability to extract all the value contained into that business data. Problems noted in the use of DM in the field of BI is related to the fact that DM models are complex in order to be directly manipulated by business users, not including BI tools. The nonexistence of BI tools allowing business users the direct manipulation of DM models was identified as the problem. More of these issues, possible solutions and conclusions are presented in this article.
Voices of Family Members and Significant Others in the Tele–Intensive Care Unit
Authors: Jahrsdoerfer Mary , Goran Susan
Published: February 2013

Background

Research suggests that tele–intensive care units (tele-ICUs) are associated with decreases in mortality rates, length of stay, and health care costs. However, little is known about the awareness and perceptions of the tele-ICU among patients’ significant others.

Objectives

To assess whether patients’ significant others were informed about the tele-ICU, what their preferences are regarding source and type of information about the tele-ICU, and what their perceptions are of the impact of the tele-ICU on patient care.

Methods

A survey was conducted with a nonprobability, convenience sample of patients’ significant others at 3 health systems.

Results

Two-thirds of patients’ significant others reported that they were uninformed about the tele-ICU and identified staff as the preferred source for this information. The 3 most important topics of information were patients’ physical privacy, impact on patient care, and the technology. Most expressed favorable perceptions of the tele-ICU.

Conclusions

This pilot study demonstrated significant gaps in communication about the tele-ICU between staff and patients’ significant others and revealed a preference to be informed about the tele-ICU by staff. Study findings will help define goals, objectives, and methods for further research to improve communication with patients’ significant others about the tele-ICU.
Family Presence in the Adult Burn Intensive Care Unit During Dressing Changes
Authors: Bishop Sarah M. , Walker Mandi D. , Spivak I. Mark
Published: February 2013

Objectives

To improve communication, discharge readiness, and satisfaction of burn patients and their families.

Methods

In March 2009, the burn intensive care unit at University of Louisville Hospital, Louisville, Kentucky, incorporated family presence during dressing changes. Adverse family events during observation, measures of patient- and family-centered care according to a standardized patient satisfaction survey, infection rates, and staff members’ response to the intervention were tracked.

Results

Through December 2011, no adverse family events occurred, patients’ satisfaction scores increased, and infection rates did not increase. Staff members responded positively to the project.

Conclusions

Allowing family presence during dressing changes provides an opportunity to educate and include patients’ family members in care delivery.
Contrast-Induced Nephropathy: Pathophysiology and Preventive Strategies
Authors: Jorgensen Ann L.
Published: February 2013

Contrast-induced nephropathy is the third most common cause of hospital-acquired renal failure, after decreased renal perfusion and nephrotoxic medications. Identification of patients at risk and implementation of preventive strategies can decrease the incidence of this nephropathy. Prevention strategies focus on counteracting vasoconstriction, enhancing blood flow through the nephron, and providing protection against injury by oxygen free radicals. Knowledge of the adverse effects associated with infusion of contrast media, identification of patients at risk for contrast-induced nephropathy, and application of evidence-based prevention strategies allow nurses to assist in the prevention of contrast-induced nephropathy.
The terrestrial invertebrate fauna of the Svalbard archipelago in a changing world: history of research and challenges
Authors: Coulson Stephen James
Published: February 2013

The High Arctic represents a unique environment, an environment from where knowledge is limited and which is currently experiencing rapid change. The archipelago of Svalbard in the European High Arctic possesses a terrestrial and freshwater invertebrate fauna that is distinctive and diverse. However, the majority of studies concentrate on the fauna of the comparatively mild west coast. Very few investigations of the colder east coast exist. Furthermore, scientific investigations are relatively recent. Scientific records of the terrestrial invertebrate fauna begin in the mid-19th century with species inventories and community descriptions but experimental field-based studies and physiological investigations did not commence until the 1980s. Some 570 articles consider this fauna, 54% of which have appeared since 1990. There is hence a dramatic and rapid increase in our understanding, which is not only improving our comprehension of Arctic ecosystem functioning but also providing a baseline for environmental change studies. Due to a largely pristine environment, a political focus and relative ease of logistics, Svalbard is set to become a focus of such studies. This article considers the state of knowledge of the terrestrial and freshwater invertebrate fauna of Svalbard, current research, and discusses the threats to the distinctive communities.
Can the Availability of Unrestricted Financial Support Improve the Quality of Care of Thalassemics in a Center with Limited Resources? A Single Center Study from India
Authors: Chakrabarti Prantar , Bohara Vinay Kumar , Ray Sudeshna , Ray Siddhartha Sankar , Nath Uttam Kumar , Chaudhuri Utpal
Published: February 2013

Comprehensive management of thalassemia demands a multidisciplinary approach, sufficient financial resources, carefully developed expertise of the care givers, as well as significant compliance on the patients’ part. Studies exploring the utility of unrestricted financing within the existing infrastructure, for the management of thalassemia, particularly in the context of a developing country, are scarce. This study aimed to assess the impact of sponsored comprehensive care compared to the routine care of thalassemics provided at Institute of Haematology and Transfusion Medicine, Kolkata, India. Two hundred and twenty patients were selected for the study and distributed in two arms. Regular monthly follow up was done including a Health Related Quality of Life (HRQoL) assessment with SF 36 v2 (validated Bengali version). Patients receiving sponsored comprehensive care showed a significant improvement in the mean hemoglobin levels and decrease in mean ferritin. HRQoL assessment revealed a better score in the physical domain though the mental health domain score was not significantly better at nine months. Unrestricted financial support in the form of comprehensive care has a positive impact on the thalassemia patients in a developing country not only in terms of clinical parameters but also in health related quality of life.