bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Komposisi Sampah dan Feeding Rate terhadap Proses Biokonversi Sampah Organik oleh Larva Black Soldier Fly (BSF)
Authors: Hartono Rini , Anggrainy Anita Dwi , Bagastyo Arseto Yekti
Published: March 2022

Biokonversi oleh larva Black Soldier Fly (BSF) menjadi metode pilihan untuk pengolahan sampah organik. Metode ini meliputi proses reduksi jumlah sampah yang dihasilkan masyarakat, pembentukan kompos dari residu sampah yang tidak terdegradasi oleh BSF, dan pertumbuhan larva BSF yang dapat digunakan untuk pakan hewan. Penelitian ini dilakukan untuk mengevaluasi seberapa besar pengaruh komposisi sampah dan feeding rate terhadap tingkat reduksi dan biokonversi sampah. Variabel penelitian berupa (i) komposisi sampah, yakni campuran 30% sampah sisa makanan (SM) dengan 70% sampah sayur (SY) atau sampah buah (B) atau sampah kebun (K), dan (ii) feeding rate (20, 35, dan 50 mg sampah organik/larva.hari). Penelitian ini dilakukan pada skala laboratorium selama 12 hari dengan menggunakan 300 ekor larva/bioreaktor. Hasil penelitian menunjukkan bahwa larva yang diberi campuran SM:SY dapat menghasilkan persentase reduksi sampah paling tinggi (81,98%), diikuti oleh campuran SM:B sebesar 81,23%, dan SM:K  sebesar 42,71%. Ditinjau dari berat akhir larva, tingkat biokonversi tertinggi didapat pada campuran SM:B dan feeding rate 35 mg sampah/larva.hari, sedangkan tingkat biokonversi terendah didapat dari campuran SM:K dan feeding rate 50 mg sampah/larva.hari. Analisis protein menunjukkan bahwa semua larva BSF dari tiap campuran sampah layak dimanfaatkan sebagai pakan hewan, karena memiliki kandungan protein antara 34– 59%.

 

Bioconversion method using Black Soldier Fly (BSF) larvae has become of great interest in organic waste treatment. This method comprises of the municipal waste reduction process, the compost production from undegraded waste, and the growth of BSF larvae that can be used further as animal feed. This study evalutes the effect of waste composition and feeding rate on the waste reduction and bioconversion level. The evaluations were done on some variables: (i) waste composition (30% food waste and 70% vegetables waste (SY) or fruit waste (B) or garden waste (K), (ii) feeding rate (20, 35, and 50 mg waste/larva.day).The experiments were conducted in a laboratory scale for 12 days using 300 larvae/bioreactor. The results show that the larvae that has been fed with SM:SY obtained the highest waste reduction (81.98%), followed by SM:B (81.23%) and SM:K (42.71%). Based on the final larvae weight, the highest bioconversion level was acquired on the SM:B composition and feeding rate of 35 mg waste/larva.day, whereas the lowest bioconversion was measured on the SM:K composition and feeding rate of 50 mg waste/larva.day. The protein analyses describes that all larvae are applicable for animal feed due to protein contents of 34–59%.
KOMUNIKASI BANK SYARIAH INDONESIA DALAM MENDORONG KARYAWAN UNTUK MENGIKUTI PROGRAM VAKSINASI
Authors: Wahyudi Nanang , Sahda Dewi , Tama Rifandi Adi Yudha
Published: March 2022

Abstrak. Penyebaran virus Covid-19 telah membuat pembatasan kegiatan yang terjadi di berbagai negara, termasuk Indonesia. Namun secara perhalan, virus mulai mereda seiring dengan kebijakan vaksinasi yang sudah diberlakukan. Vaksinasi telah menjadi syarat bagi perusahaan untuk beroperasi. Bank Syariah Indonesia (BSI) merupakan perusahaan perbankan yang menerapkan vaksinasi bagi karyawannya. Maka penelitian ini adalah kajian untuk membahas tentang upaya komunikasi yang dilakukan untuk mendorong karyawan BSI melakukan vaksinasi. Penelitian ini menggunakan metode mixed-method dengan desain sequential exploratory yaitu penelitian kualitatif terlebih dahulu dan diikuti dengan penelitian kuantitatif. Pengumpulan data kualitatif dilakukan dengan wawancara mendalam berformat open-ended question. Sementara pengumpulan data kuantitatif dilakukan dengan pengisian kuisioner yang dirancang dengan theory of planned behavior untuk mengukur minat karyawan dalam mengikuti vaksinasi. Hasil penelitian menyatakan bahwa BSI melakukan berbagai upaya komunikasi seperti melalui email, grup WhatsApp, hingga melakukan pendataan bagi karyawan yang sudah dan belum divaksin. BSI juga memantau aktivitas karyawan dengan pendataan aktivitas karyawan secara konsisten untuk mencegah penularan covid-19. Keberhasilan komunikasi BSI juga tidak lepas dari faktor-faktor eksternal seperti harus divaksinasi untuk pergi ke tempat umum, himbauan pemerintah dan saran para ulama untuk divaksinasi, serta aturan dari perusahaan BSI sendiri. Hal ini juga dibenarkan dalam analisis kuantitatif di mana faktor subjective norms merupakan faktor yang paling berpengaruh secara positif dan signifikan terhadap minat melakukan vaksinasi. Faktor attitude dan perceived behavioral control juga berpengaruh positif dan signifikan, meskipun tidak sebesar faktor subjective norms. Maka, di samping kesadaran karyawan akan manfaat vaksinasi, keberhasilan komunikasi BSI untuk menumbuhkan minat vaksinasi tidak lepas dari tekanan sosial yang mengharuskan karyawan bersedia untuk divaksin.
PENGARUH SOSIAL MEDIA TIKTOK TERHADAP GAYA HIDUP REMAJA
Authors: Khansa Shazrin Daniyah , Putri Kinkin Yuliaty Subarsa
Published: March 2022

Perkembangan internet semakin lama semakin maju hingga saat ini terutama dikalangan remaja. Internet berkembang pesat sehingga siapapun dapat menggunakannya, dimanapun dan kapanpun. Perkembangan internet juga memicu munculnya berbagai macam sosial media baru, termasuk TikTok. Kondisi pandemi covid-19 yang mengharuskan hampir seluruh dunia melakukan lockdown dan work from home guna mencegah penularan virus dan pengaruhnya sangat besar terhadap kehidupan masyarakat di Indonesia dan di seluruh dunia. TikTok merupakan aplikasi yang disukai dan popular dikalangan remaja, orang dewasa, bahkan anak kecil karena kemudahan dalam mengaksesnya untuk mendapatkan hiburan dan juga informasi. Namun, dari kemudahan akses tersebut tentunya tidak selalu menjadi hal yang baik. Dari pembahasan diatas, membuat peneliti memiliki keinginan untuk meneliti hal tersebut dengan judul “Pengaruh Sosial Media Tiktok Terhadap Gaya Hidup Remaja”. Pendekatan kuantitatif serta penggunaan metode survei digunakan pada penelitian ini. Populasi yang digunakan dalam penelitian adalah mahasiswa Ilmu Komunikasi angkatan 2019 Universitas Negeri Jakarta yang berjumlah 83 orang dengan jumlah sampel 69 orang. Dari penelitian yang dilakukan didapatkan hasil bahwa terdapat pengaruh antara sosial media TikTok dengan gaya hidup remaja.Kata kunci: Media sosial, Gaya hidup, Mahasiswa
TATA CARA PENDAFTARAN MEREK DALAM USAHA MIKRO KECIL DAN MENENGAH (UMKM) DI LINGKUNGAN KARANG TARUNA PADALARANG KABUPATEN BANDUNG BARAT
Authors: Wahyudi  , Amalia Ananda Putri Nur
Published: March 2022

This community service activity is organized by the Faculty of Law, Indonesian Computer University in collaboration with the Youth Organization Management, Padalarang District, West Bandung Regency. In the midst of the COVID-19 pandemic, the products of Micro, Small and Medium Enterprises (MSMEs) of the Padalarang District community continue to grow and become more diverse and almost every product has a brand, but the MSMEs brand owned has not been registered with the Directorate General of Intellectual Property. The method used is to conduct legal counseling through the media zoom meeting. The use of brands on MSMEs products can add higher selling value compared to unbranded products, MSMEs actors can be harmed if their products are used and even imitated in whole or in part by others because they sell well in the market. However, MSMEs actors cannot prevent and even sue because the mark has not been registered. Trademark registration is a must for MSME actors if they want to protect their rights to the mark. Trademarks to be registered are quite easy to use by utilizing online trademark registration, specifically for the registration of trademarks for MSMEs actors, the fees charged are lower than those of industrial marks. The legal protection of registered trademark rights is for 10 years and can be extended for the same time.

 

Kegiatan pengabdian kepada masyarakat ini diselenggarakan oleh Fakultas Hukum Universitas Komputer Indonesia bekerjasama dengan Pengurus Karang Taruna Kecamatan Padalarang Kabupaten Bandung Barat. Ditengah pandemi covid 19 produk Usaha Mikro Kecil dan Menengah (UMKM) masyarakat Kecamatan Padalarang terus berkembang dan semakin beragam serta hampir setiap produknya memiliki merek, akan tetapi merek UMKM yang dimiliki tersebut belum terdaftar pada Direktorat Jenderal Kekayaan Intelektual. Metode yang digunakan yaitu dengan melakukan penyuluhan hukum melalui media zoom meeting. Penggunaan merek pada produk UMKM dapat menambah nilai jual lebih tinggi dibandingkan dengan produk tanpa merek, pelaku UMKM dapat dirugikan jika produknya digunakan bahkan ditiru secara keseluruhan maupun sebagian oleh orang lain karena laku dipasaran. Akan tetapi pelaku UMKM tidak dapat mencegah bahkan menuntut dikarenakan merek tersebut belum didaftarkan. Pendaftaran merek menjadi suatu keharusan bagi pelaku UMKM jika ingin terlindungi hak atas merek tersebut. Merek yang akan didaftarkan cukup mudah dengan memanfaatkan pendaftaran merek secara online, khusus untuk pendaftaran merek pelaku UMKM biaya yang dikenakan lebih rendah dibanding dengan merek industri. Pelindungan hukum hak atas merek terdaftar selama 10 tahun dan dapat diperpanjang dengan waktu yang sama.
IMPLEMENTASI PENCEGAHAN KOMPLIKASI HIPERTENSI MELALUI THERAPEUTIC NAPE MASSAGE PADA LANSIA
Authors: Kurdi Fahruddin , Susumaningrum Latifa Aini , Rasni Hanny , Susanto Tantut
Published: March 2022

Hypertension or what is commonly called high blood pressure is an increase in systolic blood pressure above the normal limit of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg. The prevalence of hypertension in Jember Regency, the number of cases in 2014-2017 had the most cases, data on hypertension disease 22,185 cases in 2014 then increased to 29,683 in 2015. In 2017 the number of cases of hypertension occurred in women by 53,69% while men 46,31% of complications of hypertension that are left untreated will cause catastrophic disease. Hypertension is one of the diseases that often affects the elderly, but there are still many elderly people in Ledokombo District who pay less attention to their health so they don't check their blood pressure regularly. Headache is a problem that is often experienced by patients with hypertension. Halte Sehat Program is an effort made to control the health of hypertensive patients on a regular basis. Nape massage therapy is given to patients who have complaints of headache as a form of reduction in pharmacological therapy. As a result of giving therapy to 8 hypertension respondents, there were 6 respondents who experienced a decrease in pain scale and blood pressure. families are given education related to neck massage therapy so that the family can provide therapy to patients if they experience headache at any time.

Hipertensi atau yang biasa disebut tekanan darah tinggi adalah peningkatan tekanan darah sistolik di atas batas normal lebih dari 140 mmHg dan tekanan darah diastolik lebih dari 90 mmHg. Prevalensi hipertensi di Kabupaten Jember, jumlah kasus tahun 2014-2017 memiliki kasus terbanyak, data penyakit hipertensi 22.185 kasus pada tahun 2014 kemudian meningkat menjadi 29.683 pada tahun 2015. Pada tahun 2017 jumlah kasus hipertensi terjadi pada wanita sebesar 53,69% sedangkan laki-laki 46,31% komplikasi hipertensi yang tidak ditangani akan menyebabkan penyakit katastropik. Hipertensi merupakan salah satu penyakit yang sering menyerang lansia, namun masih banyak lansia di Kecamatan Ledokombo yang kurang memperhatikan kesehatannya sehingga tidak melakukan pemeriksaan tekanan darah secara rutin. Sakit kepala merupakan masalah yang sering dialami oleh penderita hipertensi. Program Halte Sehat merupakan upaya yang dilakukan untuk mengontrol kesehatan penderita hipertensi secara rutin. Terapi pijat tengkuk diberikan kepada pasien yang memiliki keluhan nyeri kepala sebagai bentuk pengurangan terapi farmakologis. Hasil dari pemberian terapi pada 8 responden hipertensi terdapat 6 responden yang mengalami penurunan skala nyeri dan tekanan darah. Keluarga diberikan edukasi terkait terapi pijat leher agar keluarga dapat memberikan terapi kepada pasien jika sewaktu-waktu mengalami sakit kepala.
PENGEMBANGAN MOTIF BATIK BERBASIS TINGGALAN ARKEOLOGI KELURAHAN LEGOK KOTA JAMBI TAHAP II
Authors: Nainunis Aulia Izza  , Ari Mukti Wardoyo Adi  , Nugrahadi Mahanani  , Wulan Resiyani  , Amor Seta Gilang Pratama
Published: March 2022

This program is a continuation of the activities in the previous year. The newest batik motifs were inspired by ornaments and archaeological remains from the Situs Candi Solok Sipin. In 2020, batik tulis, the Makara Ekikarana motif has been produced. In 2021, the team try to make batik cap inspired by the Yaksa figure on the Makara and Stupa from the Situs Candi Solok Sipin. The batik cap is related to the purpose of preparing products at affordable prices, it's hoping that the batik is marketed more broadly. In addition, this new motif can also enrich the batik repertoire at the Rumah Batik Kelurahan Legok. The method is held in stages; the first stage is the preparation. During the preparation stage, we make motif design and make coordination with the Kelurahan Legok dan Rumah Batik. After the batik cap motif is ready, the next step is to make a stamp. After the preparation stage was completed, the next step is to produce a batik cap in 3 (three) days. On the last day, we make a product launch, the products are ready to be marketed. The results achieved include the creation of the Yaksa Stupa motif which is applied to cloth and masks.
PELATIHAN DALAM PENGGUNAAN INFORMED CONSENT PADA FASILITAS PELAYANAN KESEHATAN
Authors: Setiyoargo Arief , Marbun Romaden
Published: March 2022

This Community Service activity aims to improve the quality of health services through understanding the use of informed consent. This activity begins with an initial assessment of the current state of the field in health care facilities through health workers/health cadres and residents. The initial assessment found that there was still a lack of public knowledge about medical treatment for patients and knowledge related to the use of informed consent in health facilities, especially during the current Covid-19 pandemic, the focus of health services is still centered on health protocols or physical distancing. The activity begins with preparing a plan and schedule of activities as well as the necessary equipment. The form of activities is packaged in the form of materials and videos that are shared via Google Drive online via WhatsApp groups. The activity ended with an evaluation using a google form. The results of community service activities there are as many as 57,69% of citizens' understanding in the good category, 26,92% sufficient and 15,38% less. Activities are going well and need further monitoring.

 

Kegiatan Pengabdian kepada Masyarakat ini bertujuan untuk meningkatkan kualitas pelayanan kesehatan melalui pemahaman penggunaan informed consent. Kegiatan ini diawali dengan penilaian awal kondisi terkini di lapangan di fasilitas pelayanan kesehatan melalui petugas kesehatan/kader kesehatan dan warga. Asesmen awal menemukan masih kurangnya pengetahuan masyarakat tentang penanganan medis bagi pasien dan pengetahuan terkait penggunaan informed consent di fasilitas kesehatan terutama pada masa pandemi Covid-19 saat ini, fokus pelayanan kesehatan masih berpusat pada kesehatan, protokol atau jarak fisik. Kegiatan diawali dengan penyusunan rencana dan jadwal kegiatan serta perlengkapan yang diperlukan. Bentuk kegiatan dikemas dalam bentuk materi dan video yang dibagikan melalui google drive secara online melalui grup WhatsApp. Kegiatan diakhiri dengan evaluasi menggunakan google form. Hasil kegiatan pengabdian masyarakat terdapat sebanyak 57,69% pemahaman warga dalam kategori baik, 26,92% cukup dan 15,38% kurang. Kegiatan berjalan dengan baik dan perlu pemantauan lebih lanjut.
PEMBERDAYAAN MASYARAKAT DALAM UPAYA PENCEGAHAN PENYEBARAN COVID-19 DENGAN PENERAPAN TEKNOLOGI TEPAT GUNA DI AREA BERMAIN BALITA LINGKUNGAN RW 014 KELURAHAN SERUA, CIPUTAT
Authors: Heriani Heriani , Prastati Trini , Purnama Rahmad , Silawati Tutisiana , Madya Faizal , Ni mah Alfiatun
Published: March 2022

Memasuki era Kebiasaan Baru (New normal) ini, aktivitas masyarakat perlahan kembali seperti sebelum pandemi dengan syarat protokol kesehatan harus selalu diperhatikan, dijalankan, dan ditaati. Para balita yang sudah mulai bosan bermain di dalam rumah, ingin bermain di luar rumah. Namun lingkungan pemukiman rumah belum mendukung dikarenaka tidak tersedia arena bermain yang dapat menjadi wahana bagi balita untuk bermain sambil belajar, belajar bergaul dengan kawan sebaya, belajar berinteraksi dengan kawan sebaya sambil menggunakan sarana/alat permainan, dan belajar mandiri dalam bermain sambil diawasi Ayah, Bunda, atau Pengasuh. Melalui Program Pengabdian Masyarakat ini, tim mencoba untuk membantu masyarakat mewujudkan kebutuhan akan ruang bermain anak yang dilengkapi dengan fasilitas penunjang protokol Kesehatan untuk mencegah Penyebaran Covid-19 yang ramah lingkungan dan ramah penyandang disabilitas berupa tempat cuci tangan otomatis (Touch less) bertenaga surya. Selain membantu dalam menyediakan alat teknologi  tepat guna tersebut, Pengabdian kepada Masyarakat ini juga akan melakukan sosialisasi mengenai protokol kesehatan dan pentingnya waktu bermain kepada anak-anak dan orang tua di lingkungan RW 014 Bukit Nusa Indah, Kelurahan Serua, Ciputat, Kota Tangerang Selatan.
PENATAAN MANAJEMEN KOPERASI SERBA USAHA, MASJID AL HUSNA, BUKIT INDAH, SERUA, CIPUTAT
Authors: Silawati Tutisiana , Toha Mohamad , Mardoni Yosi , Aslichati Lilik , Tampi Yoga Mohamad , Parashtiwi Ninggar
Published: March 2022

Al Husna Bukit Indah Mosque, Serua Village, since 2007, has 680 members. The business run is savings and loan and the sale of goods and services. To manage finances, activities are still done manually. The manager is retirees whose knowledge of the management of Sharia-based Multipurpose Cooperatives tends to be lacking. This community service activity intends to develop financial applications and manage management. The methods used are: 1) Identifying financial data that needs to be included in financial applications; 2) Developing financial applications; and 3) Training and assisting Al Husna Mosque administrators to use financial applications, and conducting counseling about business entities that comply with sharia principles. In this way, it is hoped that the Al Husna mosque will be able to manage its business and finances better and be able to provide better services to its members.

 

KSU-BMT Masjid Al Husna Bukit Indah, Kelurahan Serua, yang berfungsi untuk menyalurkan dana sosial dan juga sebagai koperasi sejak 2007, memiliki anggota sebanyak 680 orang. Usaha yang dijalankan berbentuk simpan pinjam dan penjualan barang dan jasa. Untuk mengelola keuangan kegiatan masih dilakukan dengan cara manual. Akibat dari aplikasi system keuangan yang pernah dimiliki rusak. Pengelola pun para pensiunan yang pengetahuan mereka tentang pengelolaan Koperasi Serba Usaha berbasis Syariah cenderung terbatas. Kegiatan pengabdian kepada masyarakat ini bermaksud melakukan pengembangan aplikasi keuangan dan penataan manajemen di Masjid ini. Metode yang dilakukan adalah: 1) Mengidentifikasi data keuangan yang perlu dimasukkan dalam aplikasi keuangan; 2) Mengembangkan aplikasi keuangan; dan 3) Melatih serta mendampingi pengurus Masjid Al Husna menggunakan aplikasi keuangan, dan melakukan penyuluhan tentang badan usaha yang memenuhi prinsip-prinsip syariah. Dengan cara demikian diharapkan nantinya masjid Al Husna mampu mengelola usaha dan keuangan secara lebih sistematis. Akhirnya akan  memberi pelayanan lebih baik kepada seluruh anggota.
PELATIHAN PENGGUNAAN APLIKASI UNTUK LAPORAN KEUANGAN BUMDES “OTABIU” DULAMAYO SELATAN, KABUPATEN GORONTALO
Authors: Irawan Windra , Pidu Yasir , Anita Andi Suci , Gerungan Raflen , Asiah Nur , Munajat Jajat
Published: March 2022

Pada Peraturan Pemerintah 11 tahun 2021 dan Permendes 3 tahun 2021 disebutkan bahwa Badan Usaha Milik Desa (BUMDes) merupakan badan hukum yang didirikan desa guna mengelola usaha, memanfaatkan aset, mengembangkan investasi dan produktivitas, menyediakan jasa pelayanan, dan/atau menyediakan jenis usaha lainnya untuk sebcsar-besarnya kesejahteraan masyarakat Desa. Dalam prosesnya pengelolaan tersebut BUMDes harus mengedepankan prinsip akuntabel dan transparan, salah satu dari cara untuk mencapainya dengan memiliki laporan keuangan dari setiap kegiatan usaha. BUMDes Otabiu Desa Dulamayo Selatan didirikan tahun 2017 yang memiliki dua unit usaha, yaitu unit usaha pembiayaan dan unit usaha penyewaan alat transportasi. Namun demikian, hingga tahun 2021 desa memberikan dana penyertaan modal dari dana desa baru satu kali, yaitu pada awal pendirian. Hal itu terjadi karena tidak adanya laporan keungan yang dapat dipertanggungjawabkan oleh pengurus BUMDes. Dengan adanya masalah ini, Universitas Terbuka–Gorontalo menyelenggarakan pelatihan pemberdayaan BUMDes salah satu diantaranya adalah penggunaan aplikasi untuk membuat laporan keuangan. Metode yang digunakan meliputi penyampaian dengan sistem ceramah meliputi pengenalan, penggunaan, diskusi dan tanya jawab mengenai masalah dalam pembuatan laporan keuangan, metode terakhir adalah praktek langsung dan solusi masalah penggunaan aplikasi. Aplikasi yang digunakan adalah “Aplikasi Sederhana Pencatatan dan Pelaporan Akuntansi Keuangan Badan Usaha Milik Desa (BUMDes)” yaitu berbasis Microsoft Excel. Aplikasi ini dipilih karena sederhana, tanpa instalasi aplikasi dan database, pengguna juga dapat dengan mudah menghapus dan memodifikasi atau menambahkan fungsi lain di dalam file untuk keperluan yang lebih khusus. Pelatihan diikuti oleh 27 peserta dari pengurus BUMDes termasuk pengawas, aparat desa, unsur masyarakat dari BPD, LPM Desa, serta pendamping lokal dan pendamping desa. Hasil yang diharapkan dari pelatihan adalah kemampuan pengurus BUMDes khususnya bendahara dalam membuat laporan keuangan melalui aplikasi serta berdampak terhadap keberhasilan memperoleh dana penyertaan desa untuk lebih memajukan usaha yang dimiliki BUMDes dalam mengelola potensi dan aset desa untuk kemajuan dan kesejahteraan masyarakat.
UPAYA MENINGKATKAN EKONOMI MELALUI BLOK KOMPOS DAN JAMUR TIRAM
Authors: Yusuf Yusuf , Prayoga Gigih Ibnu , Christianingrum Christianingrum , Yunita Anggraeni
Published: March 2022

Jamur Tiram merupakan peluang usaha yang belum digiatkan dengan baik padahal olahan produk ini diminati masyarakat dan hingga sekarang masih belum dapat memenuhi kebutuhan pasar sehingga harga jualnya menjadi mahal. Rumah Aspirasi Pemuda Bangka Belitung menggagas ide membudidayakan Jamur Tiram dan Blok kompos. Dipilih Jamur Tiram, karena bahan baku tersedia cukup banyak dan memiliki lahan yang baik. Sedangkan blok kompos adalah upaya diversifikasi atas olahan limbah sampah warga yang sudah dilakukan. Kelurahan Pangkalarang memiliki potensi yang baik untuk budidaya jamur tiram. Namun, warga belum mengetahui secara baik tentang jamur tiram, manfaat, maupun cara budidayanya. Unit pengelolaan limbah sampah mengolah hanya menjadi pupuk kompos, sehingga perlu pengenalan bahan pembuatan dan praktik blok kompos. Oleh karena itu, perlu dilakukan kegiatan Pengabdian Kepada Masyarakat (PkM) untuk mengatasinya. Kegiatan dilakukan dalam dua sub kegiatan. Pertama adalah membuat blok kompos dan kedua budidaya jamur tiram. Kedua sub kegiatan tersebut meliputi tahap survei, persiapan, sosialisasi, pelatihan, dan monitoring. Materi sosialisasi yang disampaikan adalah pemanfaatan dan pembuatan blok kompos serta pengenalan jamur tiram, manfaat, syarat tumbuh, dan cara budidaya jamur tiram. Disampaikan juga prospek peluang pasar. Produksi jamur tiram sudah 3 kali panen, yaitu bulan Agustus, September dan Oktober. Manfaat yang diperoleh adalah usaha baru yang dapat meningkatkan perekonomian masyarakat.
Application of the Aesthetic of Guqin (古琴) for Contemporary Music Composition
Authors: Wan Barry Yuk Bun
Published: March 2022

The purpose of this research is to discover the application of aesthetic approach, performing technique and playing style of Guqin for contemporary music composition. Mentioned in documents dating from two millennia, Guqin is one of the oldest Chinese solo instruments. Moreover, Guqin music often is based on senza misurato (散板, without tempo) and it focuses on changing the colours of several notes, occasionally even a single note. This is accomplished by using an open string note (散音), stopped string note (按 音), harmonic note (泛音) as well as four main ornaments (綽注吟猱) to achieve the poetic mood. This asthetic is in direct contrast to western homophonic structure. These characteristic effects offer an attractive potential for their application to new compositional techniques and approach to contemporary music writing. This research will provide valuable information regarding employment of the Guqin’s philosophy for music composition.
Sound feedback control model for live electronic performance in the Ecos Study
Authors: Thomasi Ricardo , R. A. Faria Regis
Published: March 2022

Through the Ecos Study we investigate possibilities for musical structuring based on theories of emergence, finding a fertile territory for experimentations within Agostino Di Scipio's paradigm of Audible Ecosystems. The inclusion of the acoustic environment as an active component of the musical system led us to rethink classical techniques of sound synthesis and modelling, some traditional models of electroacoustic performance, and to criticize the very role of interactions in a qualitative perspective. A positive feedback control model has been developed aiming at understanding the behaviour and the structure of the ecosystem supporting the implementation of the Spatial Instrument, a core element implemented through MAX/MSP patch and that offers a logical rationale for organizing speakers and microphones in the acoustic space. We introduce the underlying theoretical debate and present the feedback control mechanism as the basis from which the Spatial Instrument is developed.
A manipulação do Timbre a partir de estruturas da Afinação Justa
Authors: Neimog Charles , Castelões Luiz
Published: March 2022

Os processos apresentados visam estabelecer princípios para a organização de sistemas de Afinação Justa no meio eletrônico alterando parciais de timbres. Pretendemos fundir harmonia e timbre como no Espectralismo, mas partindo das teorias harmônicas de Partch (1974), Johnston (2006) e Wilson (NARUSHIMA, 2018), com o fim de modificar timbres. Focaremos particularmente na teoria na teoria Combination-Product Sets de Erv Wilson (NARUSHIMA, 2018).
Porous Se@SiO2 Nanoparticles Enhance Wound Healing by ROS-PI3K/Akt Pathway in Dermal Fibroblasts and Reduce Scar Formation
Authors: Yang Bo-Yu , Zhou Zhi-Yuan , Liu Shi-Yun , Shi Ming-Jun , Liu Xi-Jian , Cheng Tian-Ming , Deng Guo-Ying , Tian Ye , Song Jian , Li Xuan-Hao
Published: March 2022

Hypertrophic scarring, which is characterized by excessive extracellular matrix deposition and abnormal fibroblast homeostasis, is an undesirable outcome of dermal wound healing. Once formed, the scar will replace the normal function of local skin, and there are few noninvasive clinical treatments that can cure it. Se@SiO2 nanoparticles were synthesized to suppress oxidative stress, which induced the presence and activation of myofibroblasts during wound recovery. The characterization, antioxidant capacity and biological safety of Se@SiO2 NPs were evaluated. A full-thickness excisional wound model was established, and the wounds were divided into three groups. The re-epithelization and distribution of collagen fibers were assessed using hematoxylin and eosin staining and Masson’s trichome staining after specific treatments. Our results revealed that the Se@SiO2 NPs accelerated dermal wound healing and suppressed the formation of hypertrophic scars, accompanied by oxidative stress inhibition. Moreover, we found that Se@SiO2 NPs worked by activating the PI3K/Akt pathway and upregulating the phosphorylation of Akt. The findings of our study provide a new method to promote dermal scar-free wound healing by suppressing excessive oxidative stress and through PI3K/Akt pathway activation.
Multimodal EEG and Eye Tracking Feature Fusion Approaches for Attention Classification in Hybrid BCIs
Authors: Vortmann Lisa-Marie , Ceh Simon , Putze Felix
Published: March 2022

Often, various modalities capture distinct aspects of particular mental states or activities. While machine learning algorithms can reliably predict numerous aspects of human cognition and behavior using a single modality, they can benefit from the combination of multiple modalities. This is why hybrid BCIs are gaining popularity. However, it is not always straightforward to combine features from a multimodal dataset. Along with the method for generating the features, one must decide when the modalities should be combined during the classification process. We compare unimodal EEG and eye tracking classification of internally and externally directed attention to multimodal approaches for early, middle, and late fusion in this study. On a binary dataset with a chance level of 0.5, late fusion of the data achieves the highest classification accuracy of 0.609–0.675 (95%-confidence interval). In general, the results indicate that for these modalities, middle or late fusion approaches are better suited than early fusion approaches. Additional validation of the observed trend will require the use of additional datasets, alternative feature generation mechanisms, decision rules, and neural network designs. We conclude with a set of premises that need to be considered when deciding on a multimodal attentional state classification approach.
Spatial Spillover and Interaction Between High-Tech Industrial Agglomeration and Urban Ecological Efficiency
Authors: Wang Mengxin , Li Yanling , Liao Gaoke
Published: March 2022

The spatial relationship between high-tech industrial agglomeration and urban ecological efficiency has been a widespread concern. This study empirically analyzed the bidirectional influence relationship between high-tech industrial agglomeration and urban ecological efficiency and its spatial spillover effect by constructing a spatial simultaneous equation model, and based on the classification of urban resource endowment, this paper studies the heterogeneity of spatial spillover effects between high-tech industrial agglomeration and urban ecological efficiency based on the sample data of 285 cities in China from 2004 to 2017. The empirical results reveal the following: first, there is a two-way promoting effect between high-tech industrial agglomeration and urban ecological efficiency; second, there is a significant spatial spillover effect of urban ecological efficiency, that is, the urban ecological efficiency in this region is significantly positively correlated with the urban ecological efficiency in neighboring regions; third, there is a significant difference in the regional interaction between high-tech industry agglomeration and urban eco-efficiency, that is, the urban eco-efficiency in the neighboring areas has a significant negative impact on the regional high-tech industry agglomeration, while the high-tech industry agglomeration in the neighboring areas has a negative but not significant impact on the regional urban eco-efficiency; fourth, the spatial interaction spillover effects between high-tech industrial agglomeration and urban ecological efficiency are heterogeneous in terms of regional resources, and the results of regional interaction and spatial spillover effects are better in the sample study.
MultiGATAE: A Novel Cancer Subtype Identification Method Based on Multi-Omics and Attention Mechanism
Authors: Zhang Ge , Peng Zhen , Yan Chaokun , Wang Jianlin , Luo Junwei , Luo Huimin
Published: March 2022

Cancer is one of the leading causes of death worldwide, which brings an urgent need for its effective treatment. However, cancer is highly heterogeneous, meaning that one cancer can be divided into several subtypes with distinct pathogenesis and outcomes. This is considered as the main problem which limits the precision treatment of cancer. Thus, cancer subtypes identification is of great importance for cancer diagnosis and treatment. In this work, we propose a deep learning method which is based on multi-omics and attention mechanism to effectively identify cancer subtypes. We first used similarity network fusion to integrate multi-omics data to construct a similarity graph. Then, the similarity graph and the feature matrix of the patient are input into a graph autoencoder composed of a graph attention network and omics-level attention mechanism to learn embedding representation. The K-means clustering method is applied to the embedding representation to identify cancer subtypes. The experiment on eight TCGA datasets confirmed that our proposed method performs better for cancer subtypes identification when compared with the other state-of-the-art methods. The source codes of our method are available at https://github.com/kataomoi7/multiGATAE.
SGII: Systematic Identification of Essential lncRNAs in Mouse and Human Genome With lncRNA-Protein-Protein Heterogeneous Interaction Network
Authors: Xin Xiao-Hong , Zhang Ying-Ying , Gao Chu-Qiao , Min Hui , Wang Likun , Du Pu-Feng
Published: March 2022

Long noncoding RNAs (lncRNAs) play important roles in a variety of biological processes. Knocking out or knocking down some lncRNA genes can lead to death or infertility. These lncRNAs are called essential lncRNAs. Identifying the essential lncRNA is of importance for complex disease diagnosis and treatments. However, experimental methods for identifying essential lncRNAs are always costly and time consuming. Therefore, computational methods can be considered as an alternative approach. We propose a method to identify essential lncRNAs by combining network centrality measures and lncRNA sequence information. By constructing a lncRNA-protein-protein interaction network, we measure the essentiality of lncRNAs from their role in the network and their sequence together. We name our method as the systematic gene importance index (SGII). As far as we can tell, this is the first attempt to identify essential lncRNAs by combining sequence and network information together. The results of our method indicated that essential lncRNAs have similar roles in the LPPI network as the essential coding genes in the PPI network. Another encouraging observation is that the network information can significantly boost the predictive performance of sequence-based method. All source code and dataset of SGII have been deposited in a GitHub repository (https://github.com/ninglolo/SGII).
Body Mass Index, Interleukin-6 Signaling and Multiple Sclerosis: A Mendelian Randomization Study
Authors: Vandebergh Marijne , Becelaere Sara ,   CHARGE Inflammation Working Group, Dubois Bénédicte , Goris An
Published: March 2022

Objectives

We explored whether genetically predicted increased body mass index (BMI) modulates multiple sclerosis (MS) risk through interleukin-6 (IL-6) signaling.

Methods

We performed a two-sample Mendelian randomization (MR) study using multiple genome-wide association studies (GWAS) datasets for BMI, IL-6 signaling, IL-6 levels and c-reactive protein (CRP) levels as exposures and estimated their effects on risk of MS from GWAS data from the International Multiple Sclerosis Genetics Consortium (IMSGC) in 14,802 MS cases and 26,703 controls.

Results

In univariable MR analyses, genetically predicted increased BMI and IL-6 signaling were associated with higher risk of MS (BMI: odds ratio (OR) = 1.30, 95% confidence interval (CI) = 1.15-1.47,p= 3.76 × 10-5; IL-6 signaling: OR = 1.51, 95% CI = 1.11-2.04,p= 0.01). Furthermore, higher BMI was associated with increased IL-6 signaling (β = 0.37, 95% CI = 0.32,0.41,p= 1.58 × 10-65). In multivariable MR analyses, the effect of IL-6 signaling on MS risk remained after adjusting for BMI (OR = 1.36, 95% CI = 1.11-1.68,p= 0.003) and higher BMI remained associated with an increased risk for MS after adjustment for IL-6 signaling (OR = 1.16, 95% CI =1.00-1.34,p= 0.046). The proportion of the effect of BMI on MS mediated by IL-6 signaling corresponded to 43% (95% CI = 25%-54%). In contrast to IL-6 signaling, there was little evidence for an effect of serum IL-6 levels or CRP levels on risk of MS.

Conclusion

In this study, we identified IL-6 signaling as a major mediator of the association between BMI and risk of MS. Further explorations of pathways underlying the association between BMI and MS are required and will, together with our findings, improve the understanding of MS biology and potentially lead to improved opportunities for targeted prevention strategies.
The Influence of Foureye Butterflyfish (Chaetodon capistratus) and Symbiodiniaceae on the Transmission of Stony Coral Tissue Loss Disease
Authors: Titus Kara , O’Connell Lauren , Matthee Kristiaan , Childress Michael
Published: March 2022

Marine diseases have caused large scale decreases in coral cover across the Caribbean and are unfortunately projected to increase as sea surface temperatures rise. Identifying the main drivers of disease transmission is essential for our understanding and response to diseases in the future. This study investigates the effects of direct-contact, waterborne, Symbiodiniaceae composition, and butterflyfish foraging on the transmission rates of stony coral tissue loss disease (SCTLD) across Montastraea cavernosa (MCAV) coral fragments. M. cavernosa fragments were placed in direct contact with diseased Orbicella and Montastraea colonies with the purpose of creating disease MCAV fragments for experimental trials with butterflyfish. Three treatments were used to investigate waterborne transmission (control), mechanically injury to a healthy coral (limited), and direct contact feeding across a diseased and healthy coral (unlimited). After the experimental trials, the composition of Symbiodiniaceae was analyzed for every MCAV fragment. Direct contact transmission took on average 3.9 days in 2019 and 11.9 days in 2020 with significantly quicker rates of transmission between donor diseased Orbicella and Montastraea than Montastraea to Montastraea. The composition of Symbiodiniaceae differed significantly between the fragments used in 2019 (dominated by Durusdinium) than in 2020 (dominated by Cladocopium spp.). The limited treatment had the quickest time to transmission compared to the unlimited and control treatments. Symbiodiniaceae differences between 2019 and 2020 might explain differences in transmission rates and overall susceptibility between the years. The species of Symbiodiniaceae may play a role in the susceptibility of corals to the transmission of SCTLD. Additionally, we also have some suggestive evidence that butterflyfish do not directly increase infection rates, but instead might be increasing infection recovery.
Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma in situ: A Case Report
Authors: Rao Shijia , Wang Alun , Liu Wei , Yin Hongling , Li Ji , Tsang Lemuel Shui-Lun , Wu Yuhui , Shi Wei
Published: March 2022

Several cases of pigmented mammary Paget’s disease (PMPD) mimicking cutaneous malignant melanoma have been reported. In these cases, the tumor cells are colonized by melanocytes, particularly with the presence of a population of melanocytes staining for HMB-45 and S100. Here, we report a case of mammary Paget disease (MPD) which was misdiagnosed as melanoma in situ due to the interpretation of the staining of melanocytic markers S-100, Melan-A, and HMB-45. The tumor cells strongly expressed CK7 and GATA3, and a dual-labeling showed negative PHH3 labeling for the melanocytes. Pathologists need to be aware of the caveat of colonization of melanocytes in Paget disease.
Isolation of Klebsiella pneumoniae Phage vB_KpnS_MK54 and Pathological Assessment of Endolysin in the Treatment of Pneumonia Mice Model
Authors: Lu Biao , Yao Xueping , Han Guangli , Luo Zidan , Zhang Jieru , Yong Kang , Wang Yin , Luo Yan , Yang Zexiao , Ren Meishen , Cao Suizhong
Published: March 2022

With the improper use of antibiotics, an increasing number of multidrug-resistant bacteria have been reported worldwide, posing challenges for disease treatment. Klebsiella pneumoniae is an important zoonotic pathogen that colonises the respiratory tract. Endolysin therapy has emerged with the development of phages. In this study, a lytic phage vB_KpnS_MK54 was isolated from the drinking water of a forest musk deer (FMD) farm in Sichuan Province. It was the first reported phage obtained from FMD. The primary biological characteristics were determined, and whole-genome sequencing analysis was performed. The phage which belongs to the family Siphoviridae is highly specific for lytic host bacteria and is moderately adaptable to different environments. Whole-genome sequencing results showed that the phage genome size was 46,218 bp. There were 80 coding DNA sequences (CDSs) in total, 32 of which had known functions. The last CDS is the phage endolysin LysG24. A new peptide-modified endolysin (LysCA) was constituted by connecting the cecropin A peptide residues with LysG24 to investigate the antibacterial activities of both LysG24 and LysCA. The results showed that the lytic profile of LysG24 and LysCA was wider than that of phage MK54. For in vitro tests, both endolysins destroyed 99% of the host bacteria within 6 h. The lysing ability and environmental adaptability of LysCA were significantly stronger than those of LysG24. For in vivo tests, LysG24 and LysCA exhibited therapeutic effects in a mouse model of pneumonia wherewith the mice were infected with K. pneumoniae (LPKP), wherein both LysG24 and LysCA can effectively reduce the pulmonary inflammatory response. The LPKP bacterial load in the treatment group was significantly lower than that in the bacterial group, among which LysCA displayed a more obvious therapeutic effect. Furthermore, the safety test showed that the endolysins had no toxic effects on mice. In general, both LysG24 and LysCA showed excellent antibacterial activity in vivo and in vitro, with high safety and strong adaptability to the environment, manifesting their latent potential as new antimicrobial agents.
Nutrition Knowledge as a Driver of Adherence to the Mediterranean Diet in Italy
Authors: Aureli Vittoria , Rossi Laura
Published: March 2022

Background

An optimal Nutrition knowledge (NK) among the population could result in greater Adherence to the Mediterranean Diet (AMD), a recognized dietary pattern capable of preventing chronic food-related diseases. This study aimed to evaluate the association between NK and AMD in Italy.

Methods

A national representative sample of 2,869 adults took part in an assessment that was carried out through a self-administrated questionnaire including sections relating to NK and AMD. AMD was evaluated following the PREDIMED PLUS methodology. Descriptive statistics were provided, and ordinal measures of NK score and AMD were calculated based on quartiles of the quantitative scores. A contingency analysis was performed to check associations between variables.

Results

In Italy, the average NK score was 50 ± 13.3, equivalent to 56.8% of correct answers. The average value of AMD was 6.8, corresponding to 40% of the maximum score with 31.4% of the population demonstrating low AMD, 31.3% in the lower-middle range, 24% in the medium-high range, and only 13.3% reporting a high AMD. A significant association between NK and AMD was found; respondents who reported the lowest AMD corresponded to those with the lowest NK (36.7%; p < 0.05) and similarly, those with the highest level of adherence to MD also achieved the highest NK scores (41.7%; p < 0.05).

Conclusion

This study showed that AMD in Italy is generally low, and the strong association between NK and AMD demonstrated that there is a clear connection between a healthy dietary pattern and the nutrition literacy of the population. Those with the highest AMD corresponded to the highest NK and, conversely, those with the lowest AMD displayed the lowest NK. The study also highlighted that socioeconomic aspects were strong determinants of both AMD and NK.
Transcriptome Changes and Potential Immunotoxicity Analysis in RAW264.7 Macrophages Caused by Bisphenol F
Authors: Chen Huiling , Zhang Yanchao , Li Xing , Zhang Wei , He Haoqi , Du Bohai , Li Tianlan , Tang Huanwen , Liu Yungang , Li Li , Shi Ming
Published: March 2022

As a viable substitute for bisphenol A (BPA), BPF has been widely used in the plastic industry and daily consumer goods, resulting in its detection in humans at a comparable concentration. Evidence reveals that BPF and BPA may have similar toxic effects due to their similar structures. However, there is less information about BPF and its latent implications on the immune system, which is associated with many disorders. In this study, the in vitro toxicity of BPF on RAW264.7 macrophages was explored. The cells were treated with different concentrations of BPF (5, 10, 20, 50, 100, and 200 μM), the cell viability and apoptosis were detected, the gene expression profile was analyzed by whole-transcriptome sequencing, and the mRNA levels were detected by qRT-PCR. The results showed a high concentration of BPF could significantly reduce the survival rate of RAW264.7 macrophages. Although the medium concentration (20–50 μM) of BPF seemed to have no impact on the cell activity of macrophages, it caused the occurrence of apoptosis. The results of differential transcription showed that compared with the control group, 121 genes were upregulated and 82 genes were downregulated in the BPF group. The significantly changed gene functions were mainly concentrated in cell cycle, phagosome, lysosome, and antigen processing and presentation. These findings provide valuable information for correctly understanding the immunotoxicity risk of BPF and may help to improve the hazard identification of bisphenol compounds.