bluuebunny/crossref_metadata_2025 huggingface dataset:
Coronavirus Disease 2019 and Hypertension: How Anti-hypertensive Drugs Affect COVID-19 Medications and Vice Versa
Authors: Roozbeh Jamshid , Doostkam Aida , Hosseinpour Alireza , Iravani Kamyar , Malekmakan Leila , Haghpanah Abdolreza , Masjedi Fatemeh , Karimi Zeinab , Rouzbeh Hossein
Published: April 2022

Background:

As a medical problem, hypertension is one of the most common disorders in cardiovascular disease. High blood pressure has been identified as one of the most familiar risk factors for the ongoing COVID-19 pandemic. We planned to explore the possible interactions between anti-hypertensive agents and drugs targeting SARS-CoV-2 with broad investigations of these medications' mechanism of action and adverse effects.

Method:

Two co-authors searched the electronic databases (PubMed, Scopus, and Google Scholar) to collect papers relevant to the subject. The keywords searched were angiotensin-converting enzyme inhibitors (ACEI), angiotensin-II receptor blockers (ARBs), sympatholytic drugs (alpha-1 blockers, beta-blockers), vasodilators (calcium channel blockers, nitrates, and hydralazine), diuretics, chloroquine, hydroxychloroquine, lopinavir/ritonavir, remdesivir, favipiravir, interferons, azithromycin, anti-cytokine agents, glucocorticoids, anticoagulant agents, nitric oxide, and epoprostenol.

Results:

QT prolongation, arrhythmia, hypokalemia, hypertriglyceridemia are the most dangerous adverse effects in the patients on COVID-19 medications and anti-hypertensive drugs.

Conclusion:

This review emphasized the importance of the potential interaction between drugs used against COVID-19 and anti-hypertensive agents. Therefore, caution must be exercised when these medications are being used simultaneously.
iProm70: A Convolutional Neural Network-based Tool for σ70 Promoter
Classification
Authors: Shujaat Muhammad , Tayara Hilal , Chong Kil To
Published: April 2022

Background: A promoter is a DNA regulatory region typically found upstream of a gene that
plays a significant role in gene transcription regulation. Due to their function in transcription initiation,
sigma (σ) promoter sequences in bacterial genomes are important. σ70 is among the most notable sigma
factors. Therefore, the precise recognition of the σ70 promoter is essential in bioinformatics.

Objective: Several methods for predicting σ70 promoters have been developed. However, the performance
of these approaches needs to be enhanced. This study proposes a convolutional neural network
(CNN) based model iProm70 to predict σ70 promoter sequences from a bacterial genome.

Methods: This CNN-based method employs a one-hot encoding scheme to identify promoters. The
CNN model comprises three convolution layers, followed by max-pooling and a dropout layer. The architecture
tool was trained and tested on a benchmark and an independent dataset. We used four assessment
measures to determine the prediction performance.

Results: It achieved 96.10% accuracy, and the area under the receiver operating characteristic curve was
0.99.

Conclusion: According to the comparative results, iProm70 outperforms the current approaches for defining
σ70 promoter. A publicly accessible online web server is created, and it is accessible at the website:
http://nsclbio.jbnu.ac.kr/tools/Prom70-CNN/.
Trauma & Disordered Eating in Adolescents: A Review
Authors: Tocco Maria A. , Mohiuddin Sarah S.
Published: April 2022

Purpose of Review:

Trauma exposure is common, with more than half of
children and adolescents experiencing at least one traumatic event prior to
adulthood. Although diagnoses of eating disorders are less prevalent, the majority
of adolescents report engaging in disordered eating behaviors. The association
between childhood trauma exposure and disordered eating behaviors has been well
documented in adults, however, less is known about this association in adolescents.
This review summarizes the literature that exists on the adolescent population.

Recent Findings:

Multiple large-scale studies have demonstrated that adolescents
who have been exposed to trauma are more likely to engage in disordered eating
behaviors. This association was shown to exist in both sexes, although there
appears to be a higher prevalence reported in girls. There do not appear to be
significant racial or cultural factors that contribute to this association. The
experience of sexual trauma, increased trauma severity, and repeat victimization
confer an increased risk of engaging in disordered eating behaviors. There are
multiple mediators that play a role in the development of disordered eating
following a traumatic experience.
Synthesis of Oxadiazole, Imidazole, Benzimidazole, Cyclohexano
Analogues of 1, 5-benzodiazepines Through Phenoxyl/Phenylamino Linkage
Authors: Mir Mohd Amin
Published: April 2022

Aim:

To synthesize Oxadiazole, Imidazole, Benzimidazole, and Cyclohexano Analogues of 1, 5-benzodiazepines through phenoxyl/phenylamino linkage

Background:

It is worthwhile to mention that Imidazoles, benzimidazoles, oxadiazoles, are analysed extensively mainly as per their ready availability, broad chemical reactivity, and wide spectrum of biochemical activities, like antimicrobial, anti-inflammatory, antitumor, anticonvulsant drugs, anti-tubercular medicines, and having anti-HIV effect etc.

Objective:

The Oxadiazole, Imidazole, Benzimidazole derivatives were synthesized via Cyclohexano Analogues of 1, 5-benzodiazepines through phenoxyl/phenylamino linkage.

Method:

The characteristic drift of our interest towards these molecules prompted us to think about the structural modification of [1, 5]-benzodiazepine compound by incorporating on its 2-position imidazole, benzimidazole, oxadiazole, nuclei through an aminophenyl or phenoxyl bridge to synthesize these novel heterocyclic analogues of 1, 5-benzodiazepines.

Results:

These derivatives have been analysed by various spectrophometric techniques like UV, IR, NMR, and MS. The synthesis of these compounds via the mentioned methods are unique as Cyclohexano Analogues of 1, 5-benzodiazepines through phenoxyl/phenylamino is a totally new way of synthesis. The derivatives can be analysed for various properties in chemistry and pharmacology, as their parent compounds has many pharmacological properties.

Conclusion:

The synthesis of these types of compounds does provide a new hope to medicinal and pharmaceutical industries. Therefore further efforts should be taken into consideration for their synthesis and analysis of their medicinal properties.
A Review of Nanoparticles Characterization Techniques
Authors: Wadhwa Pankaj , Sharma Supriya , Sahu Sanjeev , Sharma Ajit , Kumar Deepak
Published: April 2022

Nanoparticles (NPs) are small materials of sizes 1 to 100 nm and can be divided into different
categories according to their properties, shapes, or sizes. They can be classified as metal nanoparticles,
carbon-based nanoparticles, semiconductor nanoparticles, ceramics nanoparticles, polymeric
nanoparticles, and lipid-based nanoparticles. The basic characteristics used while characterizing the
nanoparticles are morphology, size, surface charge, and optical properties. SEM, environmental SEM
(ESEM), tip-enhanced Raman spectroscopy (TERS), scanning tunneling microscopy (STM), and
TEM are used to study the topography and morphology of nanoparticles. Spectral analysis is employed
to check optical properties, while X-ray crystallography (XRD), energy-dispersive X-ray
(EDX) spectroscopy, Fourier transform infrared spectroscopy (FTIR), and fluorescence correlation
spectroscopy (FCS) are used for learning the fundamental properties of nanoparticles (NPs). This review
will focus on the utilization of these techniques in the characterization of nanoparticles.
Concussions in High School Sports in the Eastern Panhandle of West Virginia 2008-2017
Authors: Niemann Michael , Sprouse, MD, CAQSM Ryan , Harris, MD, MS, CAQSM George D. , Fiore Nathan
Published: April 2022

The incidence and prevalence of sport-related concussion has increased over the past decade as a result of an increase in athletic participation, improved diagnostic methods, and an overall increased awareness of the symptoms and signs of concussions. This is a retrospective study identifying high school athletes in the Eastern Panhandle of West Virginia who participated in baseline and post-concussion neurocognitive ImPACT testing from 2008-2017. A total of p40 unique first post injury tests were performed, and a total of 9,850 unique baseline tests were perlormed. The athletes were baseline tested at the beginning of their freshman and junior years. New students and any student who had had a concussion in the previous year were tested prior to starting, their respective sport season. The number of post-concussion tests was compared to the number of baseline tests and stratified each year by age, sex, and sport. Comparing our findings with the incidence by sport reported in the medical literature demonstrated that the same sports identified as being the highest and lowest risk were generally congruent with the sports reported to be the highest and lowest risk in two large literature reviews » B. The notable exception was cheerleading; our study found it to be among the sports with a higher incidence of concussion. A review of the literature demonstrated that cheerleaders, like participants in other contact sports, are at significant risk for concussion. Previously concussion rates in cheerleading bad been reported to be relatively low (4- 6% of cheerleading injuries) compared to other injuries and compared to concussion rates in other sports. However, concussions were noted to be the most common cheerleading injury, accounting for 31.1% of injuries. " and also reported that the number and rate of cheerleading related concussions had increased by 290% from 2001 to 2012.
A Social Media–Based Diabetes Intervention for Low-Income Mandarin-Speaking Chinese Immigrants in the United States: Feasibility Study
Authors: Hu Lu , Islam Nadia , Trinh-Shevrin Chau , Wu Bei , Feldman Naumi , Tamura Kosuke , Jiang Nan , Lim Sahnah , Wang Chan , Bubu Omonigho M , Schoenthaler Antoinette , Ogedegbe Gbenga , Sevick Mary Ann
Published: April 2022

Background

Chinese immigrants bear a high diabetes burden and face significant barriers to accessing diabetes self-management education (DSME) and counseling programs.

Objective

The goal of this study was to examine the feasibility and acceptability and to pilot test the potential efficacy of a social media–based DSME intervention among low-income Chinese immigrants with type 2 diabetes (T2D) in New York City.

Methods

This was a single group pretest and posttest study in 30 Chinese immigrants with T2D. The intervention included 24 culturally and linguistically tailored DSME videos, focusing on diabetes education and behavioral counseling techniques. Over 12 weeks, participants received 2 brief videos each week via WeChat, a free social media app popular among Chinese immigrants. Primary outcomes included the feasibility and acceptability of the intervention. Feasibility was evaluated by recruitment processes, retention rates, and the video watch rate. Acceptability was assessed via a satisfaction survey at 3 months. Secondary outcomes, that is, hemoglobin A1c (HbA1c), self-efficacy, dietary intake, and physical activity, were measured at baseline, 3 months, and 6 months. Descriptive statistics and paired 2-sided t tests were used to summarize the baseline characteristics and changes before and after the intervention.

Results

The sample population (N=30) consisted of mostly females (21/30, 70%) who were married (19/30, 63%), with limited English proficiency (30/30, 100%), and the mean age was 61 (SD 7) years. Most reported an annual household income of <US $25,000 (24/30, 80%) and a high school education or less (19/30, 63%). Thirty participants were recruited within 2 months (January and February 2020), and 97% (29/30) of the participants were retained at 6 months. A video watch rate of 92% (28/30) was achieved. The mean baseline HbA1c level was 7.3% (SD 1.3%), and this level declined by 0.5% (95% CI –0.8% to –0.2%; P=.003) at 6 months. The mean satisfaction score was 9.9 (SD 0.6) out of 10, indicating a high level of satisfaction with the program. All strongly agreed or agreed that they preferred this video-based DSME over face-to-face visits. Compared to baseline, there were significant improvements in self-efficacy, dietary, and physical activity behaviors at 6 months.

Conclusions

This pilot study demonstrated that a social media–based DSME intervention is feasible, acceptable, and potentially efficacious in a low-income Chinese immigrant population with T2D. Future studies need to examine the efficacy in an adequately powered clinical trial.
Sleeping in an Inclined Position to Reduce Snoring and Improve Sleep: In-home Product Intervention Study (Preprint)
Authors: Danoff-Burg Sharon , Rus Holly M , Weaver Morgan A , Raymann Roy J E M
Published: April 2022

BACKGROUND

Accurately and unobtrusively testing the effects of snoring and sleep interventions at home has become possible with recent advances in digital measurement technologies.

OBJECTIVE

The aim of this study was to examine the effectiveness of using an adjustable bed base to sleep with the upper body in an inclined position to reduce snoring and improve sleep, measured at home using commercially available trackers.

METHODS

Self-reported snorers (N=25) monitored their snoring and sleep nightly and completed questionnaires daily for 8 weeks. They slept flat for the first 4 weeks, then used an adjustable bed base to sleep with the upper body at a 12-degree incline for the next 4 weeks.

RESULTS

Over 1000 nights of data were analyzed. Objective snoring data showed a 7% relative reduction in snoring duration (P=.001) in the inclined position. Objective sleep data showed 4% fewer awakenings (P=.04) and a 5% increase in the proportion of time spent in deep sleep (P=.02) in the inclined position. Consistent with these objective findings, snoring and sleep measured by self-report improved.

CONCLUSIONS

New measurement technologies allow intervention studies to be conducted in the comfort of research participants’ own bedrooms. This study showed that sleeping at an incline has potential as a nonobtrusive means of reducing snoring and improving sleep in a nonclinical snoring population.
Peer Review of “The Association of Shared Care Networks With 30-Day Heart Failure Excessive Hospital Readmissions: Longitudinal Observational Study” (Preprint)
Authors: Nomali Mahin
Published: April 2022

UNSTRUCTURED

This is a peer review report related to MS ID#30777
RAZLOZI PRESTANKA DOMINACIJE SRPSKE RADIKALNE STRANKE NA DESNOJ STRANI POLITIČKE SCENE U SRBIJI
Authors: Todorovic Vladica
Published: April 2022

U radu smo istražili razloge zbog kojih je prestala dominacija Srpske radikalne stranke (SRS) na desnoj strani političke scene u Srbiji, iako je od uvođenja višepartijskog sistema 1990. najduže od svih stranaka desne orijentacije, poput Srpskog pokreta obnove (SPO) i Demokratske stranke Srbije (DSS) bila dominantna na desnoj strani političke scene. Ali nakon ukupno 17. godina dominacije na desnoj strani političke scene (od 1992. do 2000. i od 2003. do 2012.), SRS na parlamentarnim izborima 2012. prvi put nije prešla cenzus za ulazak u parlament. Pretpostavljamo da je osnovni razlog prestanka dominacije SRS na desnici prestanak kohezije elite stranke između Vojislava Šešelja, Tomislava Nikolića i Aleksandra Vučića, tri najznačajnija lidera SRS, nakon koje je došlo do podele u stranci i formiranja 2008. godine, nove stranke, Srpske napredne stranke, koja je od SRS preuzela članstvo i biračko telo. To je po nama samo bio kraj jednog procesa, tako da smo istražili i druge razloge koji su doprineli prestanku dominacije SRS na desnici u Srbiji. U radu smo koristili metodu analize sadržaja i komparativnu metodu.
A Pseudo 3D seismic refraction tomography for exploring archaeological structures
Authors: Cárdenas Soto Martín , Gámez Lindoro José Antonio , Peña Gaspar Valeria , Aguirre Díaz Juan Pablo , García Serrano Alejandro
Published: April 2022

In the seismic refraction method, refracted waves provide the velocity and irregularity of the substratum. In this study, we took advantage of this method to construct 3D images of the refractor subsurface for two rectangular arrays of sources and receivers. The procedure consists of fitting a straight line to the refracted arrival times that pass through each of the cells that discretize the study surface. The slope inverse is the P-wave velocity, and the intercept time allows us to estimate the substratum depth. We applied this method to two archaeological zones where it was necessary to know the structure of the subsoil velocity and the possible presence of anomalies associated with buried constructions. Although the technique does not allow detecting irregularities of surface layers close to the surface, the results show good agreement with the results of the 2D seismic sections. The velocity distribution shows anomalies related to buried structures and lateral discontinuities due to changes in the composition of the materials.
Air Doodle: A Realtime Virtual Drawing Tool
Authors: Pardeshi Soham , Apar Madhuvanti , Khot Chaitanya , Deshmukh Atharv
Published: April 2022

Abstract: The most fascinating and challenging research area in the field of image processing and pattern recognition in upcoming years is hype for drawing characters or visualizing characters in real-time. A few projects in the respective field have been constructed but the focus over time is to increase the accuracy and resolution with reduced tension on the timing of producing the resulting image by the system. Air doodle is another project in the respective field where the user can draw characters in real-time with the help of a pre-defined object by feeding it to the system about the object to track in order to let the user draw characters in real-time. The project proposes to reduce the usage of papers, reduce the discomfort of marking an important part in a presentation, and much more. We will be using computer vision in the open cv to build the project. The required language for this project is python, which has exhaustive libraries that would help us attain the desired result. Keywords: Machine learning, OpenCV, Morphing Techniques, Human-Computer Interactions, Air Drawing, Tkinter, Object detection, Colour detection
Stabilization of the Gravels Material for Road Sub-Base: Flexible Pavement
Authors: Barve Abhinav , Sugandhi Dr. Sunil
Published: April 2022

Abstract: In many parts of India, high-quality aggregates that match the standards are becoming increasingly scarce and expensive. High-quality aggregates are required in both the base and sub-base course according to traditional flexible pavement requirements. In many circumstances, locally available aggregates do not fit the standards, and the aggregates that do must be transported over vast distances. This act greatly raises the cost of their construction, as well as their ongoing maintenance and restoration. Thus, in a big country like India, using locally available marginal materials in flexible pavement building is one of the viable solutions to high pavement construction costs and a lack of quality aggregates sources. A broad definition of a marginal aggregate is "any aggregate that does not fully conform to the specifications used in a country for normal road aggregates but can be successfully used in special conditions, made possible by climatic characteristics or recent advances in road techniques, or after being subjected to special treatment." So, if the usage of local resources can be permitted through appropriate material or structural design modifications, construction can be hastened and significant monetary savings can be realised. The study's major goal is to add cement and bitumen emulsion to locally accessible gravel soil/marginal aggregate (Moorum) to improve its qualities. An attempt has been made to use cement for increasing the strength of the gravel and emulsion for increasing the water resisting capacity. The whole work involves increasing strength of gravel soil (Moorum) and expressed in terms of CBR and UCS value.
Campus Design of Universities: An Overview
Authors: Agrawal Preethi , Yadav Madhura
Published: April 2022

This paper reviews literature to understand the field of Campus Design and the factors impacting campus design in universities. Literature Review shows that most literature in the field of Campus Design has been authored by practising professionals and the attempt at academic research is relatively new in the field. This leads to a few often-quoted literature sources both in the global and the Indian scenario. Research into the aspect of physical planning of a campus and the quality of space as attributes to achieving effective teaching-learning and university objectives is only recently being considered. Most literature available is case-study based. Campus design parameters that help achieve university objectives need to be identified at the master plan level. Most researches, study campuses with a microscopic view of learning spaces, space comfort etc. Gross design issues which impact teaching-learning-research in Universities and provide a wholesome experience to largest user group, the student community, needs research. The new challenges faced by Indian university campuses, like the incumbent New Education Policy 2020 and situations like a global pandemic, which may affect campus design have been identified as parameters to study and consider when proposing campus design guidelines.
Citizens’ right to seek judicial review of administrative acts and its impact on governance reforms
Authors: Batalli Mirlinda , Pepaj Islam
Published: April 2022

This article analyses the right to judicial review of administrative acts and its impact on governance reforms as a result of the procedure conducted by a respective court. The article also evaluates and finds that examination of administrative acts by competent court strengths the rule of law and governance efficiency as a mechanism to guarantee the application of the principle of legality that requires that public authorities should act within a legal boundary and reasonable time to respect the citizen’s rights. Data analysis assumes on descriptive approach, an examination of the current legal framework governing the system, reports on the functioning of the oversight mechanism, empirical analyses of the topic, processed cases of administrative justice, and other published work. Administrative justice is not limited to the guarantee of citizens’ rights. Its justification also lies in the necessity to defend the public interest and to guarantee a balance between individual rights and the general interest (Woehrling, 2006). This study is of great significance and aims to contribute to the perceptive of judicial review proceedings as a narrow approach for the promotion of good administration and furthermore effective reforms. This study concludes that the administrative judiciary is one of the basic mechanisms that correct the illegal actions of the administrative bodies, prevents arbitrariness, and impact the governance reforms towards increasing efficiency, accountability, and transparency
Ablation Index-guided high-power ablation for superior vena cava isolation
Authors: cui luqian , dong shujuan , Li Jingchao , Yu Haijia , Song Huihui , han yongmei , chu yingjie
Published: April 2022

Objectives: The ablation index (AI)-guided high-power ablation
for pulmonary vein isolation (PVI) apears to be a novel strategy in
treating atrial fibrillation (AF). This study aimed to evaluate the
feasibility and safety of superior vena cava isolation (SVCI) by using
AI-guided high-power ablation strategy among patients with AF after PVI.
Methods: Data from 53 patients with AF were collected. Mapping
and ablation of SVC was performed after PVI. The ablation power was set
to 45 W and the ablation procedure was guided by AI. The SVC was divided
into six segments in a cranial view. Applications and locations of
radiofrenquency (RF) was recorded. The RF applications and AI value in
different SVC walls were compared and analyzed. Results: SVCI
was performed in 46 patients and electrical SVCIs were successfully
achieved in all patients with a mean of 7.6 ± 2.9 RF applications. The
mean time of SVCI procedure was 9.5±4.5 min. RF applications at
anteroseptal wall was 38 (10.8%) points in 20 (43.5%) patients,
posteroseptal wall was 74 (21.0%) points in 38 (82.6%) patients,
posteral wall was 81 (22.9%%) points in 40 (87.0%%) patients,
anteroseptal wall was 72 (20.4%) points in 37 (80.4%%) patients,
anterolateral wall was 45 (12.7%) points in 27 (58.7%) patients,
anteroseptal wall was 43 (12.2%) points in 23 (50.0%) patients. The
mean AI value in septal, posterior and anterior walls was higher than
that of lateral wall. There was no complication in any cases.
Conclusion: AI-guided high-power ablation is feasible and safe
strategy in performing SVCI. The RF applications and AI value in
different SVC walls varied.
Zinc Finger Protein 384 (ZNF384) Impact on Childhood Mixed Phenotype Acute Leukemia and B-Cell Precursor Acute Lymphoblastic Leukemia
Authors: Sudutan Tugce , Erbilgin Yucel , Ng Ozden Hatirnaz , Karakas Zeynep , Karaman Serap , Kucukcankurt Fulya , Ozdemir Gul Nihal , Celkan Tiraje , Cetin Timur , Gelen Sema Aylan , Hacısalihoğlu Şadan , SAYİTOĞLU MÜGE
Published: April 2022

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a
heterogeneous malignancy and consists of several genetic abnormalities.
Some of these abnormalities are used in clinic for risk calculation and
treatment decision. ZNF384 rearrangements are one of the new oncogenic
subtypes that have been identified in BCP-ALL by recent studies. Also
patients with ZNF384 fusions have been reported in with mixed phenotypic
acute leukemia (MPAL). In this study, we screened 133 pediatric patients
with ALL for the most common ZNF384 fusions; ZNF384-TCF3, ZNF384-EP300
and ZNF384-TAF15 by using qPCR. The total frequency of ZNF384 gene
rearrangements was 8.2% in the cohort. We identified ZNF384 fusions in
9.5% of mixed phenotypic leukemia and 7.6% of BCP-ALL groups.
Moreover, a novel breakpoint was identified in ZNF384-TCF3 fusion.
Patients with MPAL showed significantly higher ZNF384 expression than
BCP-ALL and controls. Patients with ZNF384 rearrangements had
intermediate survival rates based on other subtypes.
FIRST DESCRIPTION OF SEROLOGICAL EVIDENCE FOR SARS-CoV-2 IN CATTLE
Authors: Fiorito Filomena , Iovane Valentina , Pagnini Ugo , Cerracchio Claudia , Brandi Sergio , Levante Martina , Marati Luisa , Ferrara Gianmarco , Tammaro Virginio , Carlo Esterina De , Iovane Giuseppe , Fusco Giovanna
Published: April 2022

Following the coronavirus disease 2019 (COVID-19) epidemic peak in
Ariano Irpino, Campania region (Italy), we tested cattle for the
presence of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)
on a cattle farm at which, prior to the investigation, 13 of the 20
farmworkers showed COVID-19-like symptoms, and one of them died.
Twenty-four cows were sampled to detect SARS-CoV-2. All nasal and rectal
swabs and milk samples were negative for SARS-CoV-2 RNA. Of the 24
collected serum samples, 11 were positive for SARS-CoV-2 nucleocapsid
protein, 14 were positive for SARS-CoV-2 spike protein, and 13 were
positive for SARS-COV-2-neutralising antibodies; all samples were
negative for Bovine Coronavirus (BCoV), another betacoronavirus. To our
knowledge, this is the first report of natural serological evidence of
SARS-CoV-2 infection in cattle. We hypothesise that this may be a case
of reverse zoonosis. However, the role of cattle in SARS-CoV-2 infection
and transmission seems to be negligible.
Optimized medial unicompartmental knee arthroplasty outcome: learning from 20 years of propensity score matched registry data
Authors: Mikkelsen Mette , Price Andrew , Pedersen Alma Becic , Gromov Kirill , Troelsen Anders
Published: April 2022

Background and purpose: Unicompartmental knee arthroplasty (UKA) has increased in use. We investigated changes to UKA revision risk over the last 20 years compared with total knee arthroplasty (TKA), examined external and patient factors for correlation to UKA revision risk, and described the survival probability for current UKA and TKA practice.
Patients and methods: All knee arthroplasties reported to the Danish Knee Arthroplasty Register from 1997 to 2017 were linked to the National Patient Register and the Civil Registration System for comorbidity, emigration, and mortality information. All primary UKA and TKA patients with primary osteoarthritis were included and propensity score matched 4 TKAs to 1 UKA. Revision and mortality were analyzed using competing risk cox regression with a shared gamma frailty component.
Results: The matched cohort included 48,195 primary knee arthroplasties (9,639 UKAs). From 1997–2001 to 2012–2017 the 3-year hazard ratio decreased from 5.5 (95% CI 2.7–11) to 1.5 (CI 1.2–1.8) due to increased UKA survival. Cementless fixation, a high percentage usage of UKA, and increased surgical volume decreased UKA revision risk, and increased in occurrence parallel to the decreasing revision risks. Current UKA practice using cementless fixation at a high usage unit has a 3-year implant survival of 96% (CI97–95), 1.1% lower than current TKA practice.
Interpretation: UKA revision risk has decreased over the last 20 years, nearing that of TKA surgery. High usage rates, surgical volume, and the use of cementless fixation have increased during the study and were associated with decreased UKA revision risks.
Do changes in outcomes following primary and revision hip replacement differ and relate to markers of socioeconomic status? A 1-year population-based cohort study
Authors: Stisen Martin B , Klenø André N , Jacobsen Julie S , O’Connell Matthew D L , Ayis Salma , Sackley Catherine , Pedersen Alma B , Mechlenburg Inger
Published: April 2022

Background and purpose: There is little evidence on improvement after revision total hip replacement (THR). Moreover, improvements may be associated with socioeconomic status (SES). We investigated whether changes in Harris Hip Score (HHS) differ among patients undergoing primary and revision THR, and their association with markers of SES.
Patients and methods: We conducted a populationbased cohort study on 16,932 patients undergoing primary and/or revision THR from 1995 to 2018 due to hip osteoarthritis. The patients were identified in the Danish Hip Arthroplasty Registry. Outcome was defined as mean change in HHS (0–100) from baseline to 1-year follow-up, and its association with SES markers (education, cohabiting, andwealth) was analyzed using multiple linear regression adjusting for sex, age, comorbidities, and baseline HHS.
Results: At 1-year follow-up, HHS improved clinically relevant for patients undergoing both primary THR: mean 43 (95% CI 43–43) and revision THR: mean 31 (CI 29–33); however, the increase was 12 points (CI 10–14) higher for primary THR. For primary THR, improvements were 0.9 points (CI 0.4–1.5) higher for patients with high educational level compared with low educational level, 0.4 points (CI 0.0–0.8) higher for patients cohabiting compared with living alone, and 2.6 points higher (CI 2.1–3.0) for patients with high wealth compared with low wealth.
Interpretation: Patients undergoing primary THR achieve higher improvements on HHS than patients undergoing revision THR, and the improvements are negatively related to markers of low SES. Health professionals should be aware of these characteristics and be able to identify patients who may benefit from extra rehabilitation to improve outcomes after THR to ensure equality in health.
Predicting survival for hepatic arterial infusion chemotherapy of unresectable colorectal liver metastases: Radiomics analysis of pretreatment computed tomography
Authors: Liu Peng , Zhu Haitao , Zhu Haibin , Zhang Xiaoyan , Feng Aiwei , Zhu Xu , Sun Yingshi
Published: April 2022

Objective

Hepatic arterial infusion chemotherapy (HAIC) is an effective treatment for advanced unresectable colorectal cancer liver metastases (CRLM). This study was conducted to predict the efficacy of HAIC in patients with unresectable CRLM by radiomics methods based on pretreatment computed tomography (CT) examinations and clinical data.

Materials and Methods

A total of 63 patients were included in this study (41 in the training group and 22 in the validation group). All these patients underwent CT examination before HAIC. During the follow-up period, CT scans and laboratory examinations were performed regularly. Eighty-five radiological features were extracted from the regions of interest (ROIs) of CT images using the PyRadiomics program. The t-test and correlation were applied to select features. These features were analyzed using LASSO-Cox regression, and a linear model was developed to predict overall survival (OS).

Results

After reducing features by t-test and correlation test, seven features remained. After LASSO-Cox cross-validation, four features remained at λ = 0.232. They were gray level co-occurrence matrix (GLCM), gray level run length matrix (GLRLM), neighborhood gray tone difference matrix (NGTDM), and the location of the primary tumor. The C-index was 0.758 in the training group and 0.743 in the test group. Nomograms predicting 1-, 2-, and 3-year survival were established.

Conclusion

Our study demonstrates that a radiomics approach based on pretreatment CT texture analysis has the ability to predict early the outcome of HAIC in patients with advanced unresectable colorectal cancer with a high degree of accuracy and feasibility.
The concept of "Indo-Pacifica" in the context of international region building
Authors: Kuznetsov Denis Andreevich , Grachevskii Grigorii Andreevich
Published: April 2022

The article examines the concept of Indo-Pacifica as a functional international political region in the process of formation. Based on the concept of regional construction by I. Neumann, an attempt is made to identify the main actors interested in its creation, the ratio of their interests. States continue to put forward their own interpretations and visions of what Indo-Pacifica should include both in terms of geographical boundaries and in terms of its "ideological" content, norms and rules of conduct within its prospective boundaries. The purpose of the article is to determine the correlation of interests, motivation of the actors involved and to identify groups of approaches, as well as prospects for their implementation. With the help of a discourse analysis of the approaches of different countries, their characteristic features are highlighted, on the basis of which the approaches are divided into two groups - exclusive and inclusive. The evolution of the discourse around Indo-Pacifica is shown, which is connected with the evolution of the concept itself. A change in the position of some of the actors from a neutral/negative attitude to a willingness to support a new concept was revealed. The correlation of cooperation and competition in the "under construction" region is assessed. Internal and external factors of Indo-Pacifica formation are determined. The role of identity is assessed. Politically motivated confrontation and competition of projects is an integral part of regional construction in the Indo-Pacific region. Currently, within its potential borders, there is a struggle between the approaches of various States, which are thus trying to reorient the region to achieve their goals. The practical content, i.e. the nature of the international political processes taking place in the region, will also depend on which vision will eventually become dominant. The world-political significance of the ITR concept for Russia is assessed, as well as its prospects in general.
Hetero-Supramolecular Modification of Nanocrystalline TiO₂-Film Electrodes: Photoassisted Electrocatalysis at B₁₂-on-TiO₂
Authors: Mayor Marcel , Hagfeldt Anders , Grätzel Michael , Walder Lorenz
Published: April 2022

Nanocrystalline TiO2-film electrodes exhibit a unique set of intrinsic properties (transparency for visible light, electric conductivity in the doped state, semiconductor properties, large surface area, surface affinity towards organic anchoring groups). These can be combined with those of TiO2-surface-anchored molecular subunits such as light emitters or absorbers, redoxactive–possibly electrochromic–compounds, and electroactive molecular hosts or catalysts. The number of macroscopic devices resulting from such a hetero-supramolecular architecture includes photovoltaic cells, erasable photochromic devices, electrochromic displays and filters, and electrocatalytically active surfaces. The principals behind these applications are reviewed with special emphasis on a new type of photo assisted electrocatalysis using vitamin B12-modified TiO2.
Overview on Photocatalytic and Electrocatalytic Pretreatment of Industrial Non-Biodegradable Pollutants and Pesticides
Authors: Pulgarin Cesar , Kiwi John
Published: April 2022

Electrochemical and photochemical catalytic pretreatments were studied on diverse non-biodegradable industrial or toxic pollutants using different catalysts. This approach turned out also to be useful to degrade recalcitrant industrial waste waters markedly enhancing the biodegradability and biocompatibility of the treated effluents. In the case of p-toluenesulfonate, a completely non-biodegradable material from the dye industry, the TiO2 photocatalytic material applied for two hours affected total dearomatization allowing efficient subsequent biological degradation. A photochemical-biological flow reactor has been built to attain full mineralization of large volumes of diluted solutions of this xenobiotics as found in polluted water reservoirs. Fenton and photo-Fenton systems have been extensively studied in the abatement of the highly soluble Orange azo-dyes. They induce rapid destructive and low cost degradation of these textile dyes comparable to flocculation/coagulation techniques.
Homogeneous Transition-Metal Catalysis in Asymmetric C–C-Bond Formation. Back to Coordination Polymerization
Authors: Consiglio Giambattista
Published: April 2022

An account is given of the development of the author's research in the field of homogeneous catalysis by transition-metal complexes at the Laboratorium für Technische Chemie of the ETH, Zürich. The main goal is to explore the potentiality of asymmetric transition-metal catalysis
for new reactions in which C–C bonds are formed, leading to enantiomerically enriched (pure) products. Increasing attention is given to new carbonylation reactions, in particular to their exploitation for the synthesis of new stereoregular optically active polymers.
Curriculum Construction and Teacher Empowerment
Authors: Chant Richard H. , Moes Rachelle , Ross Melissa
Published: April 2022

This case study demonstrates how the Osborne-Parnes Creative Problem-solving Model (CPS) can be used to enhance teacher creativity through the collaborative and inviting processes found within Invitational Education, which counter the individualistic and product-oriented enterprises often associated with creative endeavors. Conclusions indicate that the model’s three stages guided, via sequenced divergent and convergent thinking strategies, teacher curricular decision-making and, ultimately, the learning opportunities provided to students. The CPS framework encouraged participants to engage in and experience optimism, trust, respect, care, and intentionality, which are the five value-based assumptions of Invitational Education.
Meeting Student Needs in the Freedom Writers Movie
Authors: Tanase Madalina
Published: April 2022

The study described in this paper explored the understanding pre-service teachers’ have of PK-12 student needs (i.e.Belonging, Mastery, Independence, and Generosity) and the importance of meeting these needs in a climate of InvitationalEducation. 71 undergraduate teacher education candidates enrolled in a Classroom Management course at a mid-sizedSoutheastern university in the U.S, learned about the Circle of Courage. This included viewing the movie Freedom Writers tofocus of on how this philosophy was incorporated in the movie. Following the viewing, the participants wrote an essay aboutthe significance of meeting these student needs. This activity enabled the participants to link theory to practice, as it promptedthem to take a reflective stance, identify some of the strategies they witnessed in the movie, and evaluate how these mightbenefit their future students.
Critical Imagination for Invitational Theory, Research and Practice
Authors: Novak John M.
Published: April 2022

The idea of "inviting school success" began and developed through critical and imaginative acts. Dissatisfaction with conceptualizations of school practices that negated the heart of the educative process, led to the development of an alternative framework that was more sensitive to the perceptual realities and ethical responsibilities of participants in the educative process. Imaginative invitational thinkers asked such questions as: What if we used a metaphor of "doing with" rather than "doing to" as a framework for looking at the teacher- student relationship? What if we focused on the invitational qualities of the messages intended, extended, received, and acted upon in school settings? What if we tried to make schools "the most inviting place in town?" What if we formed a network of educators who were sympathetic to these ideas? With this imaginative inception, texts have been written (Novak, 1992; Purkey, 1978; Purkey & Novak, 1984; Purkey & Strahan, 1986; Purkey & Schmidt, 1987; Purkey & Novak, 1988; Purkey & Stanley, 1991; Wilson, 1986), an International Alliance for Invitational Education has been formed, and a conceptual model (Purkey and Schmidt, 1987) has been developed. Thus, educators seeking to promote inviting practices have ample resources.
Relationship Between Pupil Control Ideology and the Quality of School Life
Authors: Schmidt Linda J.
Published: April 2022

The public school is considered a special type of service organization with respect to selectivity in the client-organization relationship. What Carlson (1964) noted almost three decades ago remains true today. That is, public schools have little choice in the selection of the clients (students) and, conversely, students have little choice in their participation in the organization of the school. The mandatory nature of the pupils' participation suggests that schools are of necessity dealing with some students who have little or no desire to take advantage of the services delivered by the school. It seems reasonable that the control of pupils would be a major concern, as well as the students' perception of the method of control upon their relationship with the school as an institution.
LGBT Health Care Access: Considering the Contributions of an Invitational Approach
Authors: MacDonnell Judith A.
Published: April 2022

Lesbian, gay, bisexual and transgender (LGBT) people have historically, and continue today to encounterbarriers to accessing health services. This has been attributed to the well-documented heterosexism,homophobia, biphobia, and transphobia that shape all health and social institutions. In this paper,invitational theory offers insight into the challenges faced by a childbearing lesbian couple to accesssupportive health care, and sheds light on inequities faced by LGBT people when accessing health care inCanada. The author draws on critical feminist research and invitational concepts to build an understandingof four dimensions of this couple’s access to supportive care. The invitational approach is combined withan explicitly critical stance to highlight gender and other relations of power, and to provide a theoreticalrationale for incorporating invitational concepts into equity-related research, including a currentapplication focused on improving LGBT home care access in the Canadian context. Given the deeplyembedded structural inequities that hinder the creation of intentionally inviting environments for diversegroups, this research has implications both for shedding light on areas in need of health care accessresearch, as well as for integrating invitational approaches that align with critical pedagogies into healthcare education.
By Their Pupils They’ll Be Taught: Using Critical Incident Questionnaire as Feedback
Authors: Jacobs Mary Ann
Published: April 2022

Can students teach their professors? The purpose of this study was to determine if students provided more immediate feedback to the professor on what engaged them and what distanced them in their learning and if the professor made changes to course delivery based on that feedback, would students become more engaged in their learning. In this action research study, a cohort of thirteen teacher education students responded bi-weekly using Critical Incident Questionnaires identifying what engaged them and what distanced them in the course. The sooner, rather than later, feedback to their professor allowed the professor to make changes to course delivery throughout the semester and thus helped students become more engaged in their own learning. The study found that the use of Critical Incident Questionnaires helped the professor assess her own teaching, make adjustments to class delivery based on student feedback to engender greater student engagement, and encourage future teachers to engage in the process of self-reflection.
Editorial
Authors: Schmidt John J.
Published: April 2022

The theory proposed and promoted in this journal was first named and is commonly referred to as invitational education. This designation was created when William Purkey and Betty Siegel, founders of this movement, first focused attention on schools, the teaching process, and student learning. Primarily, their aim was to encourage educators to establish relationships that valued students and viewed all students as capable of learning. Invitational education was a natural description for this mission. In the years following the early workshops arranged and led by Drs. Purkey and Siegel, many people from varied professions and around the world attended invitational conferences. As the audience expanded, a broader perspective developed for applying the invitational approach in a variety of institutions and organizations beyond the school setting. Professions such as nursing, business, counseling, and others are now represented among the Alliance membership, and in the process people have expanded the vision for invitational theory and practice.
Book Review: Invitational Teaching, Learning and Living
Authors: Foster Elizabeth S.
Published: April 2022

Purkey and Stanley embrace the encircling issues of school reform by beginning Invitational Teaching, Learning and Living with a warning that the mind is but one part of the whole person. They remind us that the heart cannot be forgotten in the process of change, nor can the classroom be overlooked as the essential environment that supports positive learning experiences.
Enhancement of the School Climate by Reducing Teacher Burnou
Authors: Trent Lynette M Y
Published: April 2022

Teacher burnout involves the feelings of failure andexhaustion resulting from excessive demands on a person'senergy with insufficient reward for the effort. Teacher burnouthas serious consequences for the individual, the school andstudents. For the individual, this can involve physical,psychological and/or behavioural symptoms, loss of motivation,decreased self-esteem and ultimately loss to the teachingprofession. This article outlines the objectives and the rationaleof a pilot intervention program which was implemented in aschool in the Sydney urban area (N.S.W., Australia) to respond toteacher burnout. The purpose of this intervention program was toaddress the causes of burnout and implement strategies to assistin the reduction and ultimate prevention of burnout usinginvitational theory as a foundation to create a better schoolclimate.