bluuebunny/crossref_metadata_2025 huggingface dataset:
Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells
Authors: Cao Wei , Liu Ying , Zhang Ran , Zhang Bo , Wang Teng , Zhu Xianbing , Mei Lin , Chen Hongbo , Zhang Hongling , Ming Pinghong , Huang Laiqiang
Published: July 2015

Tyrosine kinase inhibitors (TKIs) are mostly used in non-small cell lung cancer (NSCLC) treatment. Unfortunately, treatment with Gefitinib for a period of time will result in drug resistance and cause treatment failure in clinic. Therefore, exploring novel compounds to overcome this resistance is urgently required. Here we investigated the antitumor effect of homoharringtonine (HHT), a natural compound extracted from Cephalotaxus harringtonia, on Gefitinib-resistant NSCLC cell lines in vitro and in vivo. NCI-H1975 cells with EGFR T790M mutation are more sensitive to HHT treatment compared with that of A549 cells with wild type EGFR. HHT inhibited cells growth, cell viability and colony formation, as well as induced cell apoptosis through mitochondria pathway. Furthermore, we explored the mechanism of HHT inhibition on NSCLC cells. Higher level of interleukin-6 (IL-6) existed in lung cancer patients and mutant EGFR and TGFβ signal requires the upregulation of IL-6 through the gp130/JAK pathway to overactive STAT3, an oncogenic protein which has been considered as a potential target for cancer therapy. HHT reversiblely inhibited IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression. Gefitinib-resistant NSCLC xenograft tests also confirmed the antitumor effect of HHT in vivo. Consequently, HHT has the potential in Gefitinib-resistant NSCLC treatment.
Spinal mechanisms underlying potentiation of hindpaw responses observed after transient hindpaw ischemia in mice
Authors: Watanabe Tatsunori , Sasaki Mika , Komagata Seiji , Tsukano Hiroaki , Hishida Ryuichi , Kohno Tatsuro , Baba Hiroshi , Shibuki Katsuei
Published: July 2015

Transient ischemia produces postischemic tingling sensation. Ischemia also produces nerve conduction block that may modulate spinal neural circuits. In the present study, reduced mechanical thresholds for hindpaw-withdrawal reflex were found in mice after transient hindpaw ischemia, which was produced by a high pressure applied around the hindpaw for 30 min. The reduction in the threshold was blocked by spinal application of LY354740, a specific agonist of group II metabotropic glutamate receptors. Neural activities in the spinal cord and the primary somatosensory cortex (S1) were investigated using activity-dependent changes in endogenous fluorescence derived from mitochondrial flavoproteins. Ischemic treatment induced potentiation of the ipsilateral spinal and contralateral S1 responses to hindpaw stimulation. Both types of potentiation were blocked by spinal application of LY354740. The contralateral S1 responses, abolished by lesioning the ipsilateral dorsal column, reappeared after ischemic treatment, indicating that postischemic tingling sensation reflects a sensory modality shift from tactile sensation to nociception in the spinal cord. Changes in neural responses were investigated during ischemic treatment in the contralateral spinal cord and the ipsilateral S1. Potentiation already appeared during ischemic treatment for 30 min. The present findings suggest that the postischemic potentiation shares spinal mechanisms, at least in part, with neuropathic pain.
OsRDR6 plays role in host defense against double-stranded RNA virus, Rice Dwarf Phytoreovirus
Authors: Hong Wei , Qian Dan , Sun Runhong , Jiang Lin , Wang Yu , Wei Chunhong , Zhang Zhongkai , Li Yi
Published: July 2015

RNAi is a major antiviral defense response in plant and animal model systems. RNA-dependent RNA polymerase 6 (RDR6) is an essential component of RNAi, which plays an important role in the resistance against viruses in the model plants. We found previously that rice RDR6 (OsRDR6) functioned in the defense against Rice stripe virus (RSV) and Rice Dwarf Phytoreovirus (RDV) infection resulted in down-regulation of expression of RDR6. Here we report our new findings on the function of OsRDR6 against RDV. Our result showed that down-regulation of OsRDR6 through the antisense (OsRDR6AS) strategy increased rice susceptibility to RDV infection while over-expression of OsRDR6 had no effect on RDV infection. The accumulation of RDV vsiRNAs was reduced in the OsRDR6AS plants. In the OsRDR6 over-expressed plants, the levels of OsRDR6 RNA transcript and protein were much higher than that in the control plants. Interestingly, the accumulation level of OsRDR6 protein became undetectable after RDV infection. This finding indicated that the translation and/or stability of OsRDR6 protein were negatively impacted upon RDV infection. This new finding provides a new light on the function of RDR6 in plant defense response and the cross-talking between factors encoded by host plant and double-stranded RNA viruses.
Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation
Authors: Sun Yuefeng , Sun Jianwei , Lungchukiet Panida , Quarni Waise , Yang Shengyu , Zhang Xiaohong , Bai Wenlong
Published: July 2015

Fe65 is a brain-enriched adaptor protein known for its role in the action of the Aβ amyloid precursor protein in neuronal cells and Alzheimer’s disease, but little is known about its functions in cancer cells. The present study documents for the first time a role of Fe65 in suppressing breast cancer cell migration and invasion. Mechanistic studies suggest that the suppression is mediated through its phosphotyrosine binding domain 1 that mediates the recruitment of Tip60 to cortactin to stimulate its acetylation. The studies identify the Tip60 acetyltransferase as a cytoplasmic drug target for the therapeutic intervention of metastatic breast cancers.
Comparative Meta-Analysis of Tenofovir Disoproxil Fumarate versus Emtricitabine and Tenofovir Disoproxil Fumarate as Treatments for Patients with Chronic Hepatitis B
Authors: Cui Guangying , Xu Xuejun , Diao Hongyan
Published: July 2015

Tenofovir disoproxil fumarate (TDF) monotherapy has proven superior antiviral efficacy in chronic hepatitis B (CHB) patients; however, whether the combination of TDF and emtricitabine (FTC) exerts a significant advantage remains controversial. A meta-analysis was performed to comprehensively compare the therapeutic effects of FTC/TDF combination with TDF alone in CHB patients. Five studies involving 614 patients were identified and subgroup analysis was performed based on the nucleos(t)ide treatment history. Our results revealed that in patients with nucleos(t)ide-naïve treatment, there were no significant differences between the treatment groups with TDF alone and FTC/TDF combination after 12 and 24 weeks; however, the FTC/TDF combination showed better viral suppression efficacy versus TDF alone after 48 (OR = 2.16, 95% CI = 1.06–4.41, P = 0.03), 96 (OR = 2.76, 95% CI = 1.29–5.92, P = 0.009) and 192 weeks (OR = 2.60, 95% CI = 1.21–5.56, P = 0.01). In patients with nucleos(t)ide treatment history, no differences were noted between the two treatment groups after 12, 24, 48 and 96 weeks. Our results indicated that FTC/TDF combination showed better viral suppression efficacy versus TDF alone in CHB patients with nucleos(t)ide-naïve treatment, while both treatments provided similar viral suppression efficacy in CHB patients with nucleos(t)ide treatment history.
Identification of common horsetail (Equisetum arvense L.; Equisetaceae) using Thin Layer Chromatography versus DNA barcoding
Authors: Saslis-Lagoudakis C. Haris , Bruun-Lund Sam , Iwanycki Natalie E. , Seberg Ole , Petersen Gitte , Jäger Anna K. , Rønsted Nina
Published: July 2015

The global herbal products market has grown in recent years, making regulation of these products paramount for public healthcare. For instance, the common horsetail (Equisetum arvense L.) is used in numerous herbal products, but it can be adulterated with closely related species, especially E. palustre L. that can produce toxic alkaloids. As morphology-based identification is often difficult or impossible, the identification of processed material can be aided by molecular techniques. In this study, we explore two molecular identification techniques as methods of testing the purity of these products: a Thin Layer Chromatography approach (TLC-test) included in the European Pharmacopoeia and a DNA barcoding approach, used in recent years to identify material in herbal products. We test the potential of these methods for distinguishing and identifying these species using material from herbarium collections and commercial herbal products. We find that both methods can discriminate between the two species and positively identify E. arvense. The TLC-test is more cost- and time-efficient, but DNA barcoding is more powerful in determining the identity of adulterant species. Our study shows that, although DNA barcoding presents certain advantages, other established laboratory methods can perform as well or even better in confirming species’ identity in herbal products.
Resolving single membrane fusion events on planar pore-spanning membranes
Authors: Schwenen Lando L. G. , Hubrich Raphael , Milovanovic Dragomir , Geil Burkhard , Yang Jian , Kros Alexander , Jahn Reinhard , Steinem Claudia
Published: July 2015

Even though a number of different in vitro fusion assays have been developed to analyze protein mediated fusion, they still only partially capture the essential features of the in vivo situation. Here we established an in vitro fusion assay that mimics the fluidity and planar geometry of the cellular plasma membrane to be able to monitor fusion of single protein-containing vesicles. As a proof of concept, planar pore-spanning membranes harboring SNARE-proteins were generated on highly ordered functionalized 1.2 μm-sized pore arrays in Si3N4. Full mobility of the membrane components was demonstrated by fluorescence correlation spectroscopy. Fusion was analyzed by two color confocal laser scanning fluorescence microscopy in a time resolved manner allowing to readily distinguish between vesicle docking, intermediate states such as hemifusion and full fusion. The importance of the membrane geometry on the fusion process was highlighted by comparing SNARE-mediated fusion with that of a minimal SNARE fusion mimetic.
400 mW narrow-linewidth Tm-doped silica fiber laser output near 1750nm with volume Bragg grating
Authors: Quan Zhao , Gao Cunxiao , Guo Haitao , Wang Ning , Cui Xiaoxia , Xu Yantao , Peng Bo , Wei Wei
Published: July 2015

A type of Tm-doped silica fiber laser with narrow-linewidth and output wavelength near 1750 nm was firstly presented, by using a 1550 nm Er-doped fiber laser pump source and a volume Bragg grating (VBG). By means of a 15 cm Tm-doped fiber, a 400 mW continuous wave (cw) at ~1750 nm with FWHW of ~54 pm was generated, corresponding to an average slope efficiency up to 23.5% with respect to absorbed pump power. The influence of gain fiber length on the spectrum wavelength has been investigated in detail. All experimental results demonstrate that this fiber laser will be an effective and promising pump source for mid-IR laser output.
Rapid intraoperative visualization of breast lesions with γ-glutamyl hydroxymethyl rhodamine green
Authors: Ueo Hiroki , Shinden Yoshiaki , Tobo Taro , Gamachi Ayako , Udo Mitsuaki , Komatsu Hisateru , Nambara Sho , Saito Tomoko , Ueda Masami , Hirata Hidenari , Sakimura Shotaro , Takano Yuki , Uchi Ryutaro , Kurashige Junji , Akiyoshi Sayuri , Iguchi Tomohiro , Eguchi Hidetoshi , Sugimachi Keishi , Kubota Yoko , Kai Yuichiro , Shibuta Kenji , Kijima Yuko , Yoshinaka Heiji , Natsugoe Shoji , Mori Masaki , Maehara Yoshihiko , Sakabe Masayo , Kamiya Mako , Kakareka John W. , Pohida Thomas J. , Choyke Peter L. , Kobayashi Hisataka , Ueo Hiroaki , Urano Yasuteru , Mimori Koshi
Published: July 2015

We previously developed γ-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) as a tool to detect viable cancer cells, based on the fact that the enzyme γ-glutamyltranspeptidase (GGT) is overexpressed on membranes of various cancer cells, but is not expressed in normal tissue. Cleavage of the probe by GGT generates green fluorescence. Here, we examined the feasibility of clinical application of gGlu-HMRG during breast-conserving surgery. We found that fluorescence derived from cleavage of gGlu-HMRG allowed easy discrimination of breast tumors, even those smaller than 1 mm in size, from normal mammary gland tissues, with 92% sensitivity and 94% specificity, within only 5 min after application. We believe this rapid, low-cost method represents a breakthrough in intraoperative margin assessment during breast-conserving surgery.
Hypoxia inducible factor-1 mediates expression of miR-322: potential role in proliferation and migration of pulmonary arterial smooth muscle cells
Authors: Zeng Yan , Liu Hongtao , Kang Kang , Wang Zhiwei , Hui Gang , Zhang Xiaoying , Zhong Jiasheng , Peng Wenda , Ramchandran Ramaswamy , Usha Raj J. , Gou Deming
Published: July 2015

There is growing evidence that microRNAs play important roles in cellular responses to hypoxia and in pulmonary hypertensive vascular remodeling, but the exact molecular mechanisms involved are not fully elucidated. In this study, we identified miR-322 as one of the microRNAs induced in lungs of chronically hypoxic mice and rats. The expression of miR-322 was also upregulated in primary cultured rat pulmonary arterial smooth muscle cells (PASMC) in response to hypoxia. We demonstrated that HIF-1α, but not HIF-2α, transcriptionally upregulates the expression of miR-322 in hypoxia. Furthermore, miR-322 facilitated the accumulation of HIF-1α in the nucleus and promoted hypoxia-induced cell proliferation and migration. Direct targeting BMPR1a and smad5 by miR-322 was demonstrated in PASMCs suggesting that downregulation of BMP-Smad signaling pathway may be mediating the hypoxia-induced PASMC proliferation and migration. Our study implicates miR-322 in the hypoxic proliferative response of PASMCs suggesting that it may be playing a role in pulmonary vascular remodeling associated with pulmonary hypertension.
Bombyx E75 isoforms display stage- and tissue-specific responses to 20-hydroxyecdysone
Authors: Li Kang , Guo Enen , Hossain Muktadir S. , Li Qingrong , Cao Yang , Tian Ling , Deng Xiaojuan , Li Sheng
Published: July 2015

Resulted from alternative splicing of the 5′ exons, the nuclear receptor gene E75 in the silkworm, Bombyx mori, processes three mRNA isoforms, BmE75A, BmE75B and BmE75C. From the early 5th larval instar to the prepupal stages, BmE75A mRNA and protein levels in the prothoracic glands display developmental profiles similar to ecdysteroid titer. In the fat body, mRNA levels but not protein levels of all three BmE75 isoforms correlate with ecdysteroid titer; moreover, proteins of all three BmE75 isoforms disappear at the prepupal stages and a modified BmE75 protein with smaller molecular weight and cytoplasm localization occurs. At the early 5th larval instar stage, treatment of the prothoracic glands and fat body with 20-hydroxyecdysone (20E) and/or cycloheximide (CHX) revealed that BmE75A is 20E primary-responsive at both mRNA and protein levels, while BmE75B and BmE75C exhibit various responses to 20E. At the early wandering stage, RNAi-mediated reduction of gene expression of the 20E nuclear receptor complex, EcR-USP, significantly decreased mRNA and protein levels of all three BmE75 isoforms in both tissues. In conclusion, BmE75 isoforms display stage- and tissue-specific responses to 20E at both mRNA and protein levels; moreover, they are regulated by other unknown factors at the protein level.
DNA-Based Metallosupramolecular Materials
Authors: Rahbani Janane , Metera Kimberly , Sleiman Hanadi F.
Published: July 2015

This chapter reviews the current methods for site-specific incorporation of transition metals into DNA, and the applications of the resulting metal–DNA nanostructures. DNA has recently emerged as a powerful template for the programmable positioning of molecules and materials on the nanometre scale. Under specific conditions, DNA has also been shown to mediate long-range charge transport. The introduction of metals into DNA can impart this molecule with important properties, such as increased stability, redox activity, photochemical, catalytic as well as magnetic properties. In turn, the use of DNA can result in the organization of transition metal complexes into any deliberately designed structure, be it symmetrical or aperiodic. This is currently difficult to achieve using conventional supramolecular chemistry. This programmed organization of transition metals could lead to the applications of these molecules in nanoelectronics, nanooptics, data storage, light harvesting and catalysis. This review describes the synthetic approaches that achieve site-specific incorporation of metals into DNA, and the resulting synergistic ability of metals and DNA to enhance each other's properties and applications.
Constitutionally Dynamic Metallosupramolecular Systems
Authors: Barboiu Mihail
Published: July 2015

Constitutional dynamic chemistry (CDC) expressing the adaptive dynamic behaviors of both molecular and supramolecular systems potentially facilitates their self-evolution toward a selection of discrete systems from mixtures of objects reversibly exchanging and continuously reorganizing at the nano- or macroscopic levels. This chapter focuses on the implementation of constitutional dynamic chemistry principles to build dynamic constitutional metallosupramolecular systems. The basic working principles of emerging metallosupramolecular architectures are provided to better understand the requirements in system structural self-selection for the generation of functional systems. Single or double level dynamic metallosupramolecular libraries (DMLs) can be generated via metal–ligand and reversible covalent ligand bond exchanges. The metal ion coordination process may position ligands in close proximity to one another. Such proximity potentially facilitates synergistic reversible molecular exchanges and supramolecular non-covalent interactions, thereby leading to the rearrangements of the coordinating ligands within a restricted interactional space defined by the coordination geometry around the metal centers. Actual and potential applications of such systems are presented.
Recent Advances in Immobilized Ferrocene-Containing Polymers
Authors: Gallei Markus , Elbert Johannes
Published: July 2015

The interesting properties of redox-responsive ferrocene-containing polymers attached or confined on (non-)functional flat substrates, nanoparticles, in pores, in gels or at the surface of electrodes have led to manifold interesting applications utilizing their stimuli-responsive nature. Synthetic aspects for different immobilization strategies will be covered briefly, as will addressing the polarity of such materials (electro)chemically (e.g. for switching surface properties, permeability and for controlled release), host–guest complexation of ferrocene with cyclodextrins (e.g. for creating self-healing materials); novel sensing applications, as ceramic precursors and optical applications. The concepts presented herein show that confined and immobilized metallopolymers are promising candidates for the preparation of a variety of next generation high-tech materials.
Anchoring Metallosupramolecular Materials on Solid Substrates: Specific Surface–Molecule Interactions and Self-Assembly
Authors: Pace Giuseppina , Stefankiewicz Artur R.
Published: July 2015

Metallosupramolecular complexes are technologically appealing as they make new electronic, spin and optical states accessible. The proper design of the ligand and metal ion center can enable a wide variety of functionalities. However, for all of these properties to be efficiently exploited in functional devices, it is necessary to incorporate these systems into solid state structures. New challenges concerning the adsorption and assembly of metallosupramolecular complexes on solid surfaces have to be overcome before their integration into operational molecular electronic devices can be foreseen. Further chemical design of proper functional groups can address the issue of adsorption and assembly on a solid substrate. Towards this aim, covalent, van der Waals, and π–π interactions can be exploited to drive the desired binding and assembly. In this chapter, we will discuss the main strategies employed so far to confine metallosupramolecular complexes on surfaces giving particular attention to their specific interaction with the substrate. Examples of operational devices will also be presented to show the added value brought by a supramolecular approach into molecular optoelectronics and sensing.
Metallosupramolecular Materials for Magnetic Applications: Spin-Crossover
Authors: Neville Suzanne
Published: July 2015

Metallosupramolecular materials incorporating spin-crossover (SCO) properties are a rapidly expanding field of advanced materials research. Discrete species are a target for their fundamental interest as prototypes of infinite polymeric materials and for their unique SCO properties. At this time, a heptanuclear material is the highest nuclearity discrete SCO species reported. Greater nuclearities are sought for their “nano-sized” dimensions representative of the “bottom-up” approach to nano-complexes. Polymeric species are important for their cooperative SCO properties and advanced multi-functional features.
Synthesis, characterization, photophysical properties, and catalytic activity of an SCS bis(N-heterocyclic thione) (SCS-NHT) Pd pincer complex
Authors: Tyson Ginger E. , Tokmic Kenan , Oian Casey S. , Rabinovich Daniel , Valle Henry U. , Hollis T. Keith , Kelly John T. , Cuellar Kristina A. , McNamara Louis E. , Hammer Nathan I. , Webster Charles Edwin , Oliver Allen G. , Zhang Min
Published: July 2015

The first SCS-NHT pincer ligand and its Pd complex.
An ionic liquid-based microextraction method for the determination of Cu and Ni in high-salinity produced water from offshore petroleum exploration by GF AAS
Authors: Cruz Graziela F. B. , Cassella Ricardo J.
Published: July 2015

This work reports the development of a novel method for the ionic-liquid microextraction and determination of Cu and Ni in high-salinity produced water by Graphite Furnace Atomic Absorption Spectrometry (GF AAS).
SERS enhancement of silver nanoparticles prepared by a template-directed triazole ligand strategy
Authors: Kashmery Heba A. , Thompson David G. , Dondi Ruggero , Mabbott Samuel , Graham Duncan , Clark Alasdair W. , Burley Glenn A.
Published: July 2015

A one-pot method to prepare silver nanoparticle (AgNP) nanotags using the Tollens' reagent is described.
Multielectron oxidation in a ferromagnetically coupled dinickel(ii) triple mesocate
Authors: Ferrando-Soria Jesús , Fabelo Oscar , Castellano María , Cano Joan , Fordham Stephen , Zhou Hong-Cai
Published: July 2015

A first prototype of a metallamesocate-based molecular magnetic capacitor is reported featuring up to four stepwise and reversible 1 e− oxidation reactions of the two ferromagnetically coupled NiII ions to afford the stable mixed-valent Ni2II,III or Ni2III,IV and high-valent Ni2III or Ni2IV species.
Pressure-induced oligomerization of alanine at 25 °C
Authors: Fujimoto Chikako , Shinozaki Ayako , Mimura Koichi , Nishida Tamihito , Gotou Hirotada , Komatsu Kazuki , Kagi Hiroyuki
Published: July 2015

Pressure-induced oligomerization of alanine was found from high-pressure experiments.
Synthetic, structural, and luminescence study of uranyl coordination polymers containing chelating terpyridine and trispyridyltriazine ligands
Authors: Thangavelu Sonia G. , Pope Simon J. A. , Cahill Christopher L.
Published: July 2015

A series of uranyl complexes containing various O-donor aromatic dicarboxylates and N-donor chelating ligands TPY and TPTZ has been synthesized and characterized.
Unravelling the mechanism of lithium insertion into and extraction from trirutile-type LiNiFeF6 cathode material for Li-ion batteries
Authors: de Biasi L. , Lieser G. , Rana J. , Indris S. , Dräger C. , Glatthaar S. , Mönig R. , Ehrenberg H. , Schumacher G. , Binder J. R. , Geßwein H.
Published: July 2015

For possible future application as cathode material in lithium ion batteries, the lithium insertion mechanism of trirutile-type LiNiFeF6 was investigated.
Light-induced water splitting by titanium-tetrahydroxide: a computational study
Authors: Kazaryan Andranik , van Santen Rutger , Baerends Evert Jan
Published: July 2015

Light induced water splitting by Ti(OH)4 following the hydroxyl radical generation mechanism. Subsequent reactions lead to O2 and H2 production.
Surface-modified CAU-10 MOF materials as humidity sensors: impedance spectroscopic study on water uptake
Authors: Weiss Alexander , Reimer Nele , Stock Norbert , Tiemann Michael , Wagner Thorsten
Published: July 2015

Variation of the surface polarity of metal–organic frameworks caused by functional groups influences complex impedance: polar groups cause variations in water uptake, leading to measurable shifts in impedance signal.
Strong electric fields at a prototypical oxide/water interface probed by ab initio molecular dynamics: MgO(001)
Authors: Laporte Sara , Finocchi Fabio , Paulatto Lorenzo , Blanchard Marc , Balan Etienne , Guyot François , Saitta Antonino Marco
Published: July 2015

We report a density-functional theory (DFT)-based study of the interface of bulk water with a prototypical oxide surface, MgO(001), and focus our study on the often-overlooked surface electric field.
A fast self-cleaning SERS-active substrate based on an inorganic–organic hybrid nanobelt film
Authors: Hao Rui , Lin Jie , Wang Hua , Li Bo , Li Fengshi , Guo Lin
Published: July 2015

Ag@Ag(DMSO)xCl nanobelts can achieve fast self-cleaning by the photodegradation of probe molecules during the in situ SERS detection process.
Substrate effects on Li+ electrodeposition in Li secondary batteries with a competitive kinetics model
Authors: Xu Qian , Yang Yifu , Shao Huixia
Published: July 2015

The possibility of using Li22Sn5 alloy as the substrate of the metallic Li anode in Li rechargeable batteries is investigated, and a novel mechanistic model for Li+ deposition—“the competitive kinetics model” is proposed.
Facile hydrothermal synthesis of NiMoO4@CoMoO4hierarchical nanospheres for supercapacitor applications
Authors: Zhang Zhen , Liu Yundan , Huang Zongyu , Ren Long , Qi Xiang , Wei Xiaolin , Zhong Jianxin
Published: July 2015

Schematic illustration of the basis for the excellent electrochemical performance of the NiMoO4@CoMoO4nanospheres measured in an alkaline electrolyte.
Deformation twinning and the role of amino acids and magnesium in calcite hardness from molecular simulation
Authors: Côté A. S. , Darkins R. , Duffy D. M.
Published: July 2015

We employ classical molecular dynamics to calculate elastic properties and to model the nucleation and propagation of deformation twins in calcite, both as a pure crystal and with magnesium and aspartate inclusions.
Response surface methodology approach for optimization of simultaneous dye and metal ion ultrasound-assisted adsorption onto Mn doped Fe3O4-NPs loaded on AC: kinetic and isothermal studies
Authors: Asfaram Arash , Ghaedi Mehrorang , Goudarzi Alireza , Rajabi Maryam
Published: July 2015

Ultrasonic power was investigated as a dispersion and mixing tool to accelerate the adsorption of SO, MB, Pb2+ ions and Cr3+ ions onto the novel Fe3O4-NPs-AC composite.
Covalent bridging of surface functionalized Fe3O4 and YPO4:Eu nanostructures for simultaneous imaging and therapy
Authors: Barick K. C. , Sharma Anusha , Shetake Neena G. , Ningthoujam R. S. , Vatsa R. K. , Babu P. D. , Pandey B. N. , Hassan P. A.
Published: July 2015

Development of Fe3O4 decorated YPO4:Eu magnetic luminescent hybrid nanostructures (MLHN) for hyperthermia therapy and cellular imaging.
Blue-emitting heteroleptic Ir(iii) phosphors with functional 2,3′-bipyridine or 2-(pyrimidin-5-yl)pyridine cyclometalates
Authors: Duan Tainan , Chang Ting-Kuang , Chi Yun , Wang Jin-Yun , Chen Zhong-Ning , Hung Wen-Yi , Chen Chang-Hsuan , Lee Gene-Hsiang
Published: July 2015

Ir(iii) complexes with functional 2-(pyrimidin-5-yl)pyridine cyclometalates display blue electroluminescence with CIEx,ycoordinates occurring at (0.16, 0.17) at 100 cd m−2.
Ag3PO4 nanoparticles loaded on 3D flower-like spherical MoS2: a highly efficient hierarchical heterojunction photocatalyst
Authors: Wang Li , Chai Yuanyuan , Ren Jia , Ding Jing , Liu Qianqian , Dai Wei-Lin
Published: July 2015

Novel 3D hierarchical Ag3PO4/MoS2 composites were successfully prepared through a facile and reproducible hydrothermal-in situ precipitation method.
Iron nanotube-silica composite (ZVI-S-PCAT modified silica composite) preparation, characterization and application as a recyclable catalytic system for 5-membered ring organic transformations
Authors: Kour Gurpreet , Gupta Monika , Vishwanathan B. , Thirunavukkarasu K.
Published: July 2015

The ZVI-S-PCAT modified silica composite is a successful catalytic framework for synthesizing 5-membered heterocylic rings and a future sensor material.
An effective combination of electrodeposition and layer-by-layer assembly to construct composite films with luminescence switching behavior
Authors: Gao Wenmei , Ma Hongwei , Zheng Daming , Dong Zhaojun , Wu Lixin , Bi Lihua
Published: July 2015

A novel fabrication strategy for a functional composite film was explored, and the fluorescence performance was studied.
Ferrocene–isocoumarin conjugated molecules: synthesis, structural characterization, electronic properties, and DFT–TDDFT computational study
Authors: Peng Ye-Dong , Zhou Lin-Sen , Chen Li-Li , Ma Lu , Zhao Yue , Zhang Wen-Wei , Zuo Jing-Lin
Published: July 2015

Two ferrocene–isocoumarin conjugated molecules, Fc-Icm and BFc-PIcm, have been synthesized through the acid-prompted regioselective oxidative cyclization. Their redox and electronic properties are in good agreement with the DFT and TDDFT calculations.
Diverse coordination modes in tin analogues of a cyclopentadienyl anion depending on the substituents on the tin atom
Authors: Kuwabara T. , Nakada M. , Guo J. D. , Nagase S. , Saito M.
Published: July 2015

The coordination mode of stannole monoanion ligands is highly dependent on the types of substituents on the tin atom.
Metabolic suppression during mesodermal differentiation of embryonic stem cells identified by single-cell comprehensive gene expression analysis
Authors: Zhou Yuanshu , Fujisawa Ikuma , Ino Kosuke , Matsue Tomokazu , Shiku Hitoshi
Published: July 2015

Metabolic suppression has been revealed during mesodermal differentiation by using single-cell gene expression analysis.
A simple strategy for signal amplification based on DNA hybridization chain reaction for thrombin detection
Authors: Liu XiaoYing , Shen GuangYu
Published: July 2015

Multiple enzymes were introduced onto the surface of electrode, which resulted in significant signal amplification.
Enhanced ultraviolet-visible light responses of phototransistors based on single and a few ZrS3 nanobelts
Authors: Tao You-Rong , Wu Jia-Jing , Wu Xing-Cai
Published: July 2015

Phototransistors based on single and three ZrS3 nanobelts were fabricated on SiO2/Si wafers by photolithography and the lift-off technique, respectively, and the devices demonstrate an enhanced photoresponse from ultraviolet to near infrared.
Aziridine electrophiles in the functionalisation of peptide chains with amine nucleophiles
Authors: Spork Anatol P. , Donohoe Timothy J.
Published: July 2015

We describe herein the synthesis of aziridine-containing amino acids embedded within tripeptide structures.
Structural evolution of (Au2S)n (n = 1–8) clusters from first principles global optimization
Authors: Feng Yiqun , Cheng Longjiu
Published: July 2015

First principles global optimization reveals the structural evolution and novel geometries of (Au2S)n nanoclusters at n = 1–8.
Enhancement of foamability and foam stability induced by interactions between a hyperbranched exopolysaccharide and a zwitterionic surfactant dodecyl sulfobetaine
Authors: Deng Quanhua , Li Haiping , Li Chunxiu , Lv Weiqin , Li Ying
Published: July 2015

Weak hydrogen bonding and electrostatic interactions between a zwitterionic surfactant dodecyl sulfobetaine (DSB) and a hyperbranched exopolysaccharide (EPS) enhanced considerably the stability and foamability of EPS/DSB foam.
Poly(2-aminothiazole) as a unique precursor for nitrogen and sulfur co-doped porous carbon: immobilization of very small gold nanoparticles and its catalytic application
Authors: Bide Yasamin , Nabid Mohammad Reza , Dastar Fateme
Published: July 2015

We report the synthesis of poly(2-aminothiaozle) with a plate structure containing nanoparticles, and the one-step synthesis of nitrogen and sulfur co-doped porous carbon materials using P2AT as the source of both N and S.
Preparation, characterization, and in vitro release of carboxymethyl starch/β-cyclodextrin microgel–ascorbic acid inclusion complexes
Authors: Zhang Bao , Li Hongyan , Li Xiaoxiao , Cheng Chen , Jin Zhengyu , Xu Xueming , Tian Yaoqi
Published: July 2015

CMS/β-CD microgels prevented the early release of ascorbic acid in the stomach and target delivery of them to the intestine due to the ionization of carboxylic groups.
Carbastannatranes: a powerful coupling mediators in Stille coupling
Authors: Srivastav Neha , Singh Raghubir , Kaur Varinder
Published: July 2015

Carbastannatranes are better coupling mediators in Stille coupling due to easy transfer of axial Sn-bound hydrocarbyl substituent during transmetallation step.
Two reversible ferroelectric phase transitions in diisopropylammonium perchlorate
Authors: Gao Kaige , Cui Zepeng , Liu Chuang , Zhu Jiansheng , Cai Hong-Ling , Wu Xiaoshan
Published: July 2015

Two reversible first-order phase transitions were found in an improper ferroelectric, diisopropylammonium perchlorate, as the crystal symmetry transforms from P21/c to P1 at 296 K, and subsequently to P21/c at 338 K in the heating process.
Origin of order in bionanostructures
Authors: Sergeev Anton , Timchenko Alexander A. , Kryuchkov Mikhail , Blagodatski Artem , Enin Gennadiy A. , Katanaev Vladimir L.
Published: July 2015

Analysis of corneal nanocoatings across insect species provides clues to the origin of order in the bionanoworld.
A novel approach for spectrophotometric determination of succinylcholine in pharmaceutical formulation via host–guest complexation with water-soluble p-sulfonatocalixarene
Authors: Abd El-Rahman Mohamed K. , Mahmoud Amr M.
Published: July 2015

Host–guest complexation between SUC withp-sulfonatocalix[4]arene. Supramolecular complex characterization by UV & NMR spectroscopy. First spectrophotometric method for SUC determination.
Green extraction methods and environmental applications of carotenoids-a review
Authors: Singh Aarti , Ahmad Sayeed , Ahmad Anees
Published: July 2015

This review covers and discusses various aspects of carotenoids including their chemistry, classification, biosynthesis, extraction methods (conventional and non-conventional), analytical techniques and biological roles in living beings.
Microfluidic generation of uniform quantum dot-encoded microbeads by gelation of alginate
Authors: Liu Huan , Li Guohua , Sun Xiangyu , He Yonghong , Sun Shuqing , Ma Hui
Published: July 2015

A facile method was reported to generate monodispersed QD encoded alginate microbeads by employing a simple microfluidic device using an internal gelation approach. The application of the as-prepared microbeads for a suspension assay was demonstrated.
Simultaneous chemical reduction and surface functionalization of graphene oxide for efficient lubrication of steel–steel contact
Authors: Samanta Suprakash , Singh Santosh , Sahoo Rashmi. R.
Published: July 2015

A facile approach for modulating the friction and wear by functionalized graphene oxide nanolubricants for metallic sliding contact is discussed.
Fabrication of gold nanoparticles on biotin-di-tryptophan scaffold for plausible biomedical applications
Authors: Mishra Narendra Kumar , Kumar Vikas , Joshi Khashti Ballabh
Published: July 2015

AuNPs were synthesized and encapsulated by spherical scaffold of biotinylated di-tryptophan and such devices can be used for plausible biomedical applications.
Highly dispersible graphene oxide reinforced polypyrrole/polyvinyl alcohol blend nanocomposites with high dielectric constant and low dielectric loss
Authors: Deshmukh Kalim , Ahamed M. Basheer , Pasha S. K. Khadheer , Deshmukh Rajendra R. , Bhagat Pundlik R.
Published: July 2015

In the present study, we report the fabrication and characterizations of flexible dielectric nanocomposites consisting of water soluble polypyrrole (WPPy)/polyvinyl alcohol (PVA)/graphene oxide (GO) at different GO loadings (0.5–3 wt%).
Dental lessons from past to present: ultrastructure and composition of teeth from plesiosaurs, dinosaurs, extinct and recent sharks
Authors: Lübke A. , Enax J. , Loza K. , Prymak O. , Gaengler P. , Fabritius H.-O. , Raabe D. , Epple M.
Published: July 2015

Sharks and dinosaurs used fluoroapatite in their teeth, unlike their contemporary relatives, as shown by a comprehensive analysis of the composition and structure of their fossilized teeth.
Single and bicomponent anionic dyes adsorption equilibrium studies on magnolia-leaf-based porous carbons
Authors: Yu Huijing , Wang Tingting , Dai Wei , Li Xianxing , Hu Xin , Ma Na
Published: July 2015

A new type of porous carbon derived from magnolia leaf plays an important role in the adsorption of anionic dyes.
Racemic and conglomerate 1-(4-haloaryl)ethylammonium tetrachlorocobaltate salts: formation of helical structures
Authors: Mande H. M. , Ghalsasi P. S. , Arulsamy N.
Published: July 2015

Whereas rac-1-(4-fluorophenyl)ethylamine (rac-fpea) reacts with CoCl2 and HCl forming rac-[(R)-fpeaH]2[CoCl4], the chloro analogue rac-1-(4-chlorophenyl)ethylamine (rac-cpea) yields a conglomerate of [(R)-cpeaH]3[CoCl4]Cl and [(S)-cpeaH]3[CoCl4]Cl.
Magnetic chemiluminescent immunoassay for human C-reactive protein on the centrifugal microfluidics platform
Authors: Czilwik G. , Vashist S. K. , Klein V. , Buderer A. , Roth G. , von Stetten F. , Zengerle R. , Mark D.
Published: July 2015

Schematic of the LabDisk-based hCRP MCIA. The antibody-coated dynabeads are sequentially transported through the immunoassay buffers by magnetic actuation. Finally the chemiluminescence signal is acquired from a detection cavity.
Bridged bicyclic peptides as potential drug scaffolds: synthesis, structure, protein binding and stability
Authors: Bartoloni Marco , Jin Xian , Marcaida Maria José , Banha João , Dibonaventura Ivan , Bongoni Swathi , Bartho Kathrin , Gräbner Olivia , Sefkow Michael , Darbre Tamis , Reymond Jean-Louis
Published: July 2015

Diastereomeric norbornapeptides represent globular scaffolds with geometries determined by the chirality of amino acid residues and sharing structural features of β-turns and α-helices.
A pH-activatable and aniline-substituted photosensitizer for near-infrared cancer theranostics
Authors: Tian Jiangwei , Zhou Jinfeng , Shen Zhen , Ding Lin , Yu Jun-Sheng , Ju Huangxian
Published: July 2015

A trifunctional photosensitizer was designed to achieve highly selective near-infrared tumor imaging, efficient photodynamic therapy and therapeutic self-monitoring.
Taming the beast: fluoromesityl groups induce a dramatic stability enhancement in boroles
Authors: Zhang Zuolun , Edkins Robert M. , Haehnel Martin , Wehner Marius , Eichhorn Antonius , Mailänder Lisa , Meier Michael , Brand Johannes , Brede Franziska , Müller-Buschbaum Klaus , Braunschweig Holger , Marder Todd B.
Published: July 2015

Boroles with a fluoromesityl group on the B atom have greatly improved air stability compared to their mesityl analogues.
Molten salt electrochemical synthesis of sodium titanates as high performance anode materials for sodium ion batteries
Authors: Li Haomiao , Wang Kangli , Li Wei , Cheng Shijie , Jiang Kai
Published: July 2015

Sodium titanates are synthesized via a facile molten salt based electrochemical route and exhibit high performance for Na+ storage.
Vertically ordered SnO2 nanobamboos for substantially improved detection of volatile reducing gases
Authors: Jeon Jong-Myeong , Shim Young-Seok , Han Su Deok , Kim Do Hong , Kim Yeon Hoo , Kang Chong-Yun , Kim Jin-Sang , Kim Miyoung , Jang Ho Won
Published: July 2015

We report a novel method to utilize metal nanoparticles on the whole surface of vertically ordered 1D nanostructures using multiple deposition steps based on a glancing-angle deposition technique for the first time.
Improved rate capability of the conducting functionalized FTO-coated Li-[Li0.2Mn0.54Ni0.13Co0.13]O2 cathode material for Li-ion batteries
Authors: Zhu Xiaoming , Wang Yanxia , Shang Kehui , He Wei , Ai Xinping , Yang Hanxi , Cao Yuliang
Published: July 2015

FTO-LRMO nanoparticles were synthesized by a simple polymer-pyrolysis method and then coated with FTO to form a conductive protection layer. The FTO-LRMO electrode exhibits enhanced rate capability and cycling stability.
Binary transition metal nitrides with enhanced activity and durability for the oxygen reduction reaction
Authors: Tian Xinlong , Luo Junming , Nan Haoxiong , Fu Zhiyong , Zeng Jianhuang , Liao Shijun
Published: July 2015

Binary transition metal nitrides demonstrate high activity and stability/durability for the oxygen reduction reaction in both acid and alkaline media.
Photocatalytic reduction of CO2 with water promoted by Ag clusters in Ag/Ga2O3 photocatalysts
Authors: Yamamoto Muneaki , Yoshida Tomoko , Yamamoto Naoto , Nomoto Toyokazu , Yamamoto Yuta , Yagi Shinya , Yoshida Hisao
Published: July 2015

The structure and function of the Ag cocatalyst in Ag loaded Ga2O3 photocatalysts for photocatalytic CO2 reduction with water were investigated. It was found that around 1 nm sized Ag clusters had strong interactions with the Ga2O3 surface and promoted the formation of bidentate formate species as the reaction intermediate for the CO production.
A multi-responsive intrinsically disordered protein (IDP)-directed green synthesis of fluorescent gold nanoclusters
Authors: Balu Rajkamal , Bourgeois Laure , Elvin Christopher M. , Hill Anita J. , Choudhury Namita R. , Dutta Naba K.
Published: July 2015

Herein we demonstrate the green synthesis of fluorescent gold nanoclusters (AuNCs) using a multi-responsive intrinsically disordered protein (IDP) polymer, Rec1-resilin, as a multi-functional template.
Rewritable magnetic fluorescence-encoded microspheres: preparation, characterization, and recycling
Authors: Li Yan , Wu Youshen , Luo Cheng , Wang Bo , Wu Daocheng
Published: July 2015

Rewritable magnetic fluorescence-encoded microspheres were prepared by coating magnetic microspheres with a fluorescence-encoded shell which could be erased by calcination.
Atomic layer deposition of transparent semiconducting oxide CuCrO2 thin films
Authors: Tripathi T. S. , Niemelä Janne-Petteri , Karppinen Maarit
Published: July 2015

Atomic layer deposition (ALD) is a vital gas-phase technique for atomic-level thickness-controlled deposition of high-quality thin films of CuCrO2 on various substrate morphologies owing to its self-limiting gas-surface reaction mechanism.
Zr5Sb3−xRux, a new superconductor in the W5Si3 structure type
Authors: Xie Weiwei , Luo Huixia , Phelan Brendan F. , Cava Robert J.
Published: July 2015

W5Si3-type Zr5Sb3−xRux and Tl5Te3 structure types both supporting superconductivity, are derived from the parent Al2Cu type structure.
2.5 Gbit/s burst‐mode receiver with rapid response and high tolerance to CIDs for PON systems
Authors: Mita D. , Yoshima S. , Noda M.
Published: July 2015

A 2.5 Gbit/s burst‐mode receiver for passive optical network (PON) systems with both a fast receiver settling time of 24.1 ns and a high tolerance to consecutive identical digits (CIDs) of 629 bits, by using a preamplifier with a unique peak‐detecting automatic gain control function is developed. It is broadly applicable to the time‐ and wavelength‐division multiplexed‐PON systems of NG‐PON2, which need a wide dynamic range suitable for a 64‐way split and a transmission distance exceeding 40 km.
Surface plasmon resonant splitting and merging due to infrared incidence through thermal imaging lens
Authors: Hwang Jehwan , Jeon Jiyeon , Yoon Sujin , Kang Byung Soo , Kim Deok‐Kee , Kim Ha Sul , Kang Sang‐Woo , Kim Jun Oh , Jang Woo‐Yong , Urbas Augustine , Ku Zahyun , Lee Sang Jun
Published: July 2015

In previous work, the present authors discovered the resonant splitting phenomenon of a plasmonic perforated gold film (PGF), as the incident light comes in the polar angle. However, in reality, the light through the imaging lens could be incident on the PGF not only in the polar angle but also in the azimuth angle. The transmission of a PGF against the incident light is analysed in both polar and azimuth angles in spherical coordinates. To mimic the incidence through the lens, a PGF sample is rotated by simultaneously varying both types of angles as normal incidence arrives. For the measurement, the sample has been fabricated with a PGF on a semi‐insulating gallium arsenide (GaAs) substrate. The measured transmission spectra show both resonant splitting and merging under TM and TE polarisations as the azimuth angle is increased. Results drawn from this work will pave the way to fully understanding the interaction between the imaging lens and the plasmonic structure (PGF).
Compact broadband balun‐based UWB‐BPF with minimum insertion loss and sharp selectivity
Authors: Ghazali A.N. , Sazid M. , Pal S.
Published: July 2015

A novel and compact ultra‐wideband (UWB) bandpass filter (BPF) based on the broadband balun mechanism is proposed. The proposed structure is made up of two back‐to‐back open circuited meandered microstrip lines on the top plane coupled in a broadside fashion with a short circuited co‐planar waveguide in the ground. This configuration gives rise to a smooth UWB passband with an insertion loss of <0.19 dB in simulation and two transmission zeros at the lower and upper passband edges which provide sharp selectivity. To confirm the theory a prototype is fabricated and its measured response is found to be in close agreement with the simulated response. The proposed structure is very small in size measuring only 14.6 × 7.3 mm2.
Note: Improved line strengths of rovibrational and rotational transitions within the X3Σ− ground state of NH
Authors: Brooke James S. A. , Bernath Peter F. , Western Colin M.
Published: July 2015

Recently, a line list including positions and transition strengths was published for the NH X3Σ− rovibrational and rotational transitions. The calculation of the transition strengths requires a conversion of transition matrix elements from Hund’s case (b) to (a). The method of this conversion has recently been improved during other work on the OH X2Π rovibrational transitions, by removing an approximation that was present previously. The adjusted method has been applied to the NH line list, resulting in more accurate transition strengths. An updated line list is presented that contains all possible transitions with v′ and v″ up to 6, and J up to between 25 and 44, depending on the band.
Determining energy relaxation length scales in two-dimensional electron gases
Authors: Billiald Jordan , Backes Dirk , König Jürgen , Farrer Ian , Ritchie David , Narayan Vijay
Published: July 2015

We present measurements of the energy relaxation length scale ℓ in two-dimensional electron gases (2DEGs). A temperature gradient is established in the 2DEG by means of a heating current, and then the elevated electron temperature Te is estimated by measuring the resultant thermovoltage signal across a pair of deferentially biased bar-gates. We adapt a model by Rojek and König [Phys. Rev. B 90, 115403 (2014)] to analyse the thermovoltage signal and as a result extract ℓ, Te, and the power-law exponent αi for inelastic scattering events in the 2DEG. We show that in high-mobility 2DEGs, ℓ can attain macroscopic values of several hundred microns, but decreases rapidly as the carrier density n is decreased. Our work demonstrates a versatile low-temperature thermometry scheme, and the results provide important insights into heat transport mechanisms in low-dimensional systems and nanostructures. These insights will be vital for practical design considerations of future nanoelectronic circuits.