bluuebunny/crossref_metadata_2025 huggingface dataset:
Methamphetamine Use in HIV-infected Individuals Affects T-cell Function and Viral Outcome during Suppressive Antiretroviral Therapy
Authors: Massanella Marta , Gianella Sara , Schrier Rachel , Dan Jennifer M. , Pérez-Santiago Josué , Oliveira Michelli F. , Richman Douglas D. , Little Susan J. , Benson Constance A. , Daar Eric S. , Dube Michael P. , Haubrich Richard H. , Smith Davey M. , Morris Sheldon R.
Published: August 2015

We investigated the associations between methamphetamine (meth) use, immune function and the dynamics of HIV and cytomegalovirus [CMV] in the blood and genital tract of HIV-infected ART-suppressed subjects. Self-reported meth use was associated with increased CD4+ and CD8+ T-cell proliferation (Ki67+, p < 0.005), CD4+ T-cell activation (CD45RA–CD38+, p = 0.005) and exhaustion (PD-1+, p = 0.0004) in blood, compared to non-meth users. Meth use was also associated with a trend towards higher blood HIV DNA levels (p = 0.09) and more frequent shedding of CMV in seminal plasma (p = 0.002). To explore possible mechanisms, we compared ex vivo spontaneous and antigen-specific proliferation in PBMC collected from subjects with and without positive meth detection in urine (Utox+ vs. Utox-). Despite higher levels of spontaneous proliferation, lymphocytes from Utox+ meth users had a significantly lower proliferative capacity after stimulation with a number of pathogens (CMV, candida, mycobacterium, toxoplasma, HIV, p < 0.04 in all cases), compared to Utox- participants. Our findings suggest that meth users have greater proliferation and exhaustion of the immune system. Meth use is also associated with a loss of control of CMV replication, which could be related to loss of immune response to pathogens. Future studies should consider meth use as a potential modulator of T-cell responses.
Investigation of Inhibition Mechanism of Chemokine Receptor CCR5 by Micro-second Molecular Dynamics Simulations
Authors: Salmas Ramin Ekhteiari , Yurtsever Mine , Durdagi Serdar
Published: August 2015

Chemokine receptor 5 (CCR5) belongs to G protein coupled receptors (GPCRs) and plays an important role in treatment of human immunodeficiency virus (HIV) infection since HIV uses CCR5 protein as a co-receptor. Recently, the crystal structure of CCR5-bound complex with an approved anti-retroviral drug (maroviroc) was resolved. During the crystallization procedure, amino acid residues (i.e., Cys224, Arg225, Asn226 and Glu227) at the third intra-cellular loop were replaced by the rubredoxin for stability reasons. In the current study, we aimed to understand the impact of the incorporated rubredoxin on the conformations of TM domains of the target protein. For this reason, rubredoxin was deleted from the crystal structure and the missing amino acids were engineered. The resultant structure was subjected to long (μs) molecular dynamics (MD) simulations to shed light into the inhibitory mechanism. The derived model structure displayed a significant deviation in the cytoplasmic domain of TM5 and IC3 in the absence of rubredoxin. The principal component analyses (PCA) and MD trajectory analyses revealed important structural and dynamical differences at apo and holo forms of the CCR5.
Efficient Optical Energy Harvesting in Self-Accelerating Beams
Authors: Bongiovanni Domenico , Hu Yi , Wetzel Benjamin , Robles Raul A. , Mendoza González Gregorio , Marti-Panameño Erwin A. , Chen Zhigang , Morandotti Roberto
Published: August 2015

We report the experimental observation of energetically confined self-accelerating optical beams propagating along various convex trajectories. We show that, under an appropriate transverse compression of their spatial spectra, these self-accelerating beams can exhibit a dramatic enhancement of their peak intensity and a significant decrease of their transverse expansion, yet retaining both the expected acceleration profile and the intrinsic self-healing properties. We found our experimental results to be in excellent agreement with the numerical simulations. We expect further applications in such contexts where power budget and optimal spatial confinement can be important limiting factors.
Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability
Authors: Ottosson Nina E , Wu Xiongyu , Nolting Andreas , Karlsson Urban , Lund Per-Eric , Ruda Katinka , Svensson Stefan , Konradsson Peter , Elinder Fredrik
Published: August 2015

Voltage-gated ion channels generate cellular excitability, cause diseases when mutated and act as drug targets in hyperexcitability diseases, such as epilepsy, cardiac arrhythmia and pain. Unfortunately, many patients do not satisfactorily respond to the present-day drugs. We found that the naturally occurring resin acid dehydroabietic acid (DHAA) is a potent opener of a voltage-gated K channel and thereby a potential suppressor of cellular excitability. DHAA acts via a non-traditional mechanism, by electrostatically activating the voltage-sensor domain, rather than directly targeting the ion-conducting pore domain. By systematic iterative modifications of DHAA we synthesized 71 derivatives and found 32 compounds more potent than DHAA. The most potent compound, Compound 77, is 240 times more efficient than DHAA in opening a K channel. This and other potent compounds reduced excitability in dorsal root ganglion neurons, suggesting that resin-acid derivatives can become the first members of a new family of drugs with the potential for treatment of hyperexcitability diseases.
Understanding Solidification of Polythiophene Thin Films during Spin-Coating: Effects of Spin-Coating Time and Processing Additives
Authors: Na Jin Yeong , Kang Boseok , Sin Dong Hun , Cho Kilwon , Park Yeong Don
Published: August 2015

Spin-coating has been used extensively in the fabrication of electronic devices; however, the effects of the processing parameters have not been fully explored. Here, we systematically characterize the effects of the spin-coating time on the microstructure evolution during semiconducting polymer solidification in an effort to establish the relationship between this parameter and the performances of the resulting polymer field-effect transistors (FETs). We found that a short spin-coating time of a few seconds dramatically improve the morphology and molecular order in a conjugated polymer thin film because the π-π stacking structures formed by the polymer molecules grow slowly and with a greater degree of order due to the residual solvent present in the wet film. The improved ordering is correlated with improved charge carrier transport in the FETs prepared from these films. We also demonstrated the effects of various processing additives on the resulting FET characteristics as well as on the film drying behavior during spin-coating. The physical properties of the additives are found to affect the film drying process and the resulting device performance.
Fabrication of Microfluidic Valves Using a Hydrogel Molding Method
Authors: Sugiura Yusuke , Hirama Hirotada , Torii Toru
Published: August 2015

In this paper, a method for fabricating a microfluidic valve made of polydimethylsiloxane (PDMS) using a rapid prototyping method for microchannels through hydrogel cast molding is discussed. Currently, the valves in microchannels play an important role in various microfluidic devices. The technology to prototype microfluidic valves rapidly is actively being developed. For the rapid prototyping of PDMS microchannels, a method that uses a hydrogel as the casting mold has been recently developed. This technique can be used to prepare a three-dimensional structure through simple and uncomplicated methods. In this study, we were able to fabricate microfluidic valves easily using this rapid prototyping method that utilizes hydrogel cast molding. In addition, we confirmed that the valve displacement could be predicted within a range of constant pressures. Moreover, because microfluidic valves fabricated using this method can be directly observed from a cross-sectional direction, we anticipate that this technology will significantly contribute to clarifying fluid behavior and other phenomena in microchannels and microfluidic valves with complex structures.
Social, spatial and temporal organization in a complex insect society
Authors: Quevillon Lauren E. , Hanks Ephraim M. , Bansal Shweta , Hughes David P.
Published: August 2015

High-density living is often associated with high disease risk due to density-dependent epidemic spread. Despite being paragons of high-density living, the social insects have largely decoupled the association with density-dependent epidemics. It is hypothesized that this is accomplished through prophylactic and inducible defenses termed ‘collective immunity’. Here we characterise segregation of carpenter ants that would be most likely to encounter infectious agents (i.e. foragers) using integrated social, spatial and temporal analyses. Importantly, we do this in the absence of disease to establish baseline colony organization. Behavioural and social network analyses show that active foragers engage in more trophallaxis interactions than their nest worker and queen counterparts and occupy greater area within the nest. When the temporal ordering of social interactions is taken into account, active foragers and inactive foragers are not observed to interact with the queen in ways that could lead to the meaningful transfer of disease. Furthermore, theoretical resource spread analyses show that such temporal segregation does not appear to impact the colony-wide flow of food. This study provides an understanding of a complex society’s organization in the absence of disease that will serve as a null model for future studies in which disease is explicitly introduced.
Parity and Cardiovascular Disease Mortality: a Dose-Response Meta-Analysis of Cohort Studies
Authors: Lv Haichen , Wu Hongyi , Yin Jiasheng , Qian Juying , Ge Junbo
Published: August 2015

Parity has been shown to inversely associate with cardiovascular disease (CVD) mortality, but the evidence of epidemiological studies is still controversial. Therefore, we quantitatively assessed the relationship between parity and CVD mortality by summarizing the evidence from prospective studies. We searched MEDLINE (PubMed), EMBASE and ISI Web of Science databases for relevant prospective studies of parity and CVD mortality through the end of March 2015. Fixed- or random-effects models were used to estimate summary relative risks (RRs) and 95% confidence intervals (CIs). Heterogeneity among studies was assessed using the I2 statistics. All statistical tests were two-sided. Ten prospective studies were included with a total of 994,810 participants and 16,601 CVD events. A borderline significant inverse association was observed while comparing parity with nulliparous, with summarized RR = 0.79 (95% CI: 0.60–1.06; I2 = 90.9%, P < 0.001). In dose-response analysis, we observed a significant nonlinear association between parity number and CVD mortality. The greatest risk reduction appeared when the parity number reached four. The findings of this meta-analysis suggests that ever parity is inversely related to CVD mortality. Furthermore, there is a statistically significant nonlinear inverse association between parity number and CVD mortality.
Pathway-Based Genome-wide Association Studies Reveal That the Rac1 Pathway Is Associated with Plasma Adiponectin Levels
Authors: Li Wei-Dong , Jiao Hongxiao , Wang Kai , Yang Fuhua , Grant Struan F. A. , Hakonarson Hakon , Ahima Rexford , Arlen Price R.
Published: August 2015

Pathway-based analysis as an alternative and effective approach to identify disease-related genes or loci has been verified. To decipher the genetic background of plasma adiponectin levels, we performed genome wide pathway-based association studies in extremely obese individuals and normal-weight controls. The modified Gene Set Enrichment Algorithm (GSEA) was used to perform the pathway-based analyses (the GenGen Program) in 746 European American females, which were collected from our previous GWAS in extremely obese (BMI > 35 kg/m2) and never-overweight (BMI<25 kg/m2) controls. Rac1 cell motility signaling pathway was associated with plasma adiponectin after false-discovery rate (FDR) correction (empirical P < 0.001, FDR = 0.008, family-wise error rate = 0.008). Other several Rac1-centered pathways, such as cdc42racPathway (empirical P < 0.001), hsa00603 (empirical P = 0.003) were among the top associations. The RAC1 pathway association was replicated by the ICSNPathway method, yielded a FDR = 0.002. Quantitative pathway analyses yielded similar results (empirical P = 0.001) for the Rac1 pathway, although it failed to pass the multiple test correction (FDR = 0.11). We further replicated our pathway associations in the ADIPOGen Consortium data by the GSA-SNP method. Our results suggest that Rac1 and related cell motility pathways might be associated with plasma adiponectin levels and biological functions of adiponectin.
Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1
Authors: Hu An , Huang Jing-Juan , Li Rui-Lin , Lu Zhao-Yang , Duan Jun-Li , Xu Wei-Hua , Chen Xiao-Ping , Fan Jing-Ping
Published: August 2015

SIRT1 is one of seven mammalian homologs of Sir2 that catalyzes NAD+-dependent protein deacetylation. The aim of the present study is to explore the effect of SIRT1 small molecule activator on the anticancer activity and the underlying mechanism. We examined the anticancer activity of a novel oral agent, curcumin, which is the principal active ingredient of the traditional Chinese herb Curcuma Longa. Treatment of FaDu and Cal27 cells with curcumin inhibited growth and induced apoptosis. Mechanistic studies showed that anticancer activity of curcumin is associated with decrease in migration of HNSCC and associated angiogenesis through activating of intrinsic apoptotic pathway (caspase-9) and extrinsic apoptotic pathway (caspase-8). Our data demonstrating that anticancer activity of curcumin is linked to the activation of the ATM/CHK2 pathway and the inhibition of nuclear factor-κB. Finally, increasing SIRT1 through small molecule activator curcumin has shown beneficial effects in xenograft mouse model, indicating that SIRT1 may represent an attractive therapeutic target. Our studies provide the preclinical rationale for novel therapeutics targeting SIRT1 in HNSCC.
Non-immune immunoglobulins shield Schistosoma japonicum from host immunorecognition
Authors: Wu Chuang , Hou Nan , Piao Xianyu , Liu Shuai , Cai Pengfei , Xiao Yan , Chen Qijun
Published: August 2015

Schistosomiasis is a major human parasitic disease with a global impact. Schistosoma japonicum, the most difficult to control, can survive within host veins for decades. Mechanisms of immune evasion by the parasite, including antigenic variation and surface masking, have been implicated but not well defined. In this study, we defined the immunoglobulin-binding proteomes of S. japonicum using human IgG, IgM and IgE as the molecular bait for affinity purification, followed by protein identification by liquid chromatography with tandem mass spectrometry (LC-MS/MS). Several proteins situated at the tegument of S. japonicum were able to nonselectively bind to the Fc domain of host immunoglobulins, indicating a mechanism for the avoidance of host immune attachment and recognition. The profile of the immunoglobulin-binding proteomes provides further clues for immune evasion mechanisms adopted by S. japonicum.
Imaging real-time HIV-1 virion fusion with FRET-based biosensors
Authors: Jones Daniel M. , Padilla-Parra Sergi
Published: August 2015

We have produced a novel, simple and rapid method utilising genetically encodable FRET-based biosensors to permit the detection of HIV-1 virion fusion in living cells. These biosensors show high sensitivity both spatially and temporally and allow the real-time recovery of HIV-1 fusion kinetics in both single cells and cell populations simultaneously.
An in solution assay for interrogation of affinity and rational minimer design for small molecule-binding aptamers
Authors: Frost Nadine R. , McKeague Maureen , Falcioni Darren , DeRosa Maria C.
Published: August 2015

An adaptation of the DNase I footprinting assay allows for the screening of aptamer binding affinity for small molecule targets, and provides structural information for the rational design of minimers.
Multimodal chemical imaging of molecular messengers in emerging Pseudomonas aeruginosa bacterial communities
Authors: Baig Nameera F. , Dunham Sage J. B. , Morales-Soto Nydia , Shrout Joshua D. , Sweedler Jonathan V. , Bohn Paul W.
Published: August 2015

Raman and SIMS imaging elucidate the spatial and temporal organization of quinolones in P. aeruginosa colonies on agar, planktonic cells, and static biofilms.
Removable interpenetrating network enables highly-responsive 2-D photonic crystal hydrogel sensors
Authors: Coukouma Andrew E. , Smith Natasha L. , Asher Sanford A.
Published: August 2015

An interpenetrating poly(vinyl alcohol) cryogel enables the utilization of highly responsive but highly fragile hydrogel sensors.
Ion mobility-mass spectrometry of charge-reduced protein complexes reveals general trends in the collisional ejection of compact subunits
Authors: Bornschein Russell E. , Ruotolo Brandon T.
Published: August 2015

Multiprotein complexes have been shown to play critical roles across a wide range of cellular functions, but most probes of protein quaternary structure are limited in their ability to analyze complex mixtures and polydisperse structures using small amounts of total protein.
A simple paper-strip colorimetric method utilizing dehydrogenase enzymes for analysis of food components
Authors: Monošík Rastislav , Bezerra dos Santos Vagner , Angnes Lúcio
Published: August 2015

A simple chromatographic paper based colorimetric assay for the analysis of selected food compounds.
Hyaluronic acid-conjugated apoferritin nanocages for lung cancer targeted drug delivery
Authors: Luo Yanan , Wang Xuenv , Du Dan , Lin Yuehe
Published: August 2015

In this paper, we proposed a naturally derived protein cage based pH-responsive delivery system for intracellular prodrug controlled release.
A hexaphenylbenzene based AIEE active two photon probe for the detection of hydrogen sulfide with tunable self-assembly in aqueous media and application in live cell imaging
Authors: Pramanik Subhamay , Bhalla Vandana , Kim Hwan Myung , Singh Hardev , Lee Hyo Won , Kumar Manoj
Published: August 2015

AIEE active HPB based TPE probe exhibited modulation of self-assembled architecture in presence of H2S and was utilized for TPM imaging for detection of H2S in HeLa cells.
Reversible morphology transitions of supramolecular polymer self-assemblies for switch-controlled drug release
Authors: Zhang Haitao , Fan Xiaodong , Suo Rongtian , Li Hui , Yang Zhen , Zhang Wanbin , Bai Yang , Yao Hao , Tian Wei
Published: August 2015

A novel method for switch-controlled drug release was developed through reversible morphology transitions from vesicles to nanoparticles based on supramolecular branched copolymer self-assemblies.
Intermolecular C–H activation with an Ir-METAMORPhos piano-stool complex – multiple reaction steps at a reactive ligand
Authors: Oldenhof S. , Lutz M. , van der Vlugt J. I. , Reek J. N. H.
Published: August 2015

Reaction of phenylacetylene with an IrIII(METAMORPhos) complex generates a unique four-membered IrPNC metallacyclic species with an exocyclic CC fragment.
Continuous and convergent access to vicinyl amino alcohols
Authors: Nobuta Tomoya , Xiao Guozhi , Ghislieri Diego , Gilmore Kerry , Seeberger Peter H.
Published: August 2015

A four module convergent chemical assembly system delivers two classes of vicinyl amino alcohol and five APIs.
Luminogenic iridium azide complexes
Authors: Ohata Jun , Vohidov Farrukh , Aliyan Amirhossein , Huang Kewei , Martí Angel A. , Ball Zachary T.
Published: August 2015

We describe a modular synthesis of iridium complexes that exhibit luminogenic behavior in biorthogonal conjugation reactions for cellular imaging applications.
Quantitative SERS-based DNA detection assisted by magnetic microspheres
Authors: Zhang Jinnan , Joshi Padmanabh , Zhou Yan , Ding Rui , Zhang Peng
Published: August 2015

We report a quantitative SERS measurement scheme based on the magnetic microsphere–Ag nanoparticles to detect target DNA.
Core–shell hierarchical WO2/WO3 microspheres as an electrocatalyst support for methanol electrooxidation
Authors: Zhou Yang , Hu Xian-Chao , Liu Xi-Hui , Wen He-Rui
Published: August 2015

Core–shell WO2/WO3 microspheres were used to prepare a Pt–WO2/WO3 catalyst with a mass specific current of 694 mA mg−1 which is 1.4 and 3.0 times greater than those of commercial PtRu/C and Pt/WO3.
Developmental considerations for ethanolates with regard to stability and physicochemical characterization of efonidipine hydrochloride ethanolate
Authors: Otsuka M. , Maeno Y. , Fukami T. , Inoue M. , Tagami T. , Ozeki T.
Published: August 2015

Efonidipine hydrochloride ethanolate arranges the chloride ion within a basket-type conformation. This distinctive crystal structure would contribute to the improvement of the API's thermal stability.
Facile preparation of Chevreul's salt (Cu2SO3·CuSO3·2H2O) mesocrystalline microspheres and their high photocatalytic activity
Authors: Guan Mingyun , Jian Yan , Sun Jianhua , Shang Tongming , Liu Qi , Xu Zheng
Published: August 2015

Cu2SO3·CuSO3·2H2O mesocrystalline microspheres with excellent photocatalytic performance, composed of sub-microparticles in an oriented fashion, are synthesized by a facile method.
Synthetic strategies for new vanadium oxyfluorides containing novel building blocks: structures of V(iv) and V(v) containing Sr4V3O5F13, Pb7V4O8F18, Pb2VO2F5, and Pb2VOF6
Authors: Yeon Jeongho , Felder Justin B. , Smith Mark D. , Morrison Gregory , zur Loye Hans-Conrad
Published: August 2015

Four novel vanadium oxyfluorides (VOFs) featuring new crystallographic building blocks were crystallizedviaa mild hydrothermal route.
Towards an understanding of the singlet–triplet splittings in conjugated hydrocarbons: azulene investigated by anion photoelectron spectroscopy and theoretical calculations
Authors: Vosskötter Stefan , Konieczny Paul , Marian Christel M. , Weinkauf Rainer
Published: August 2015

Electron density overlaps are correlated with singlet triplet splittings: azulene as a test case.
Acetylene as an essential building block for prebiotic formation of pyrimidine bases on Titan
Authors: Jeilani Yassin A. , Fearce Chelesa , Nguyen Minh Tho
Published: August 2015

Prebiotic building blocks for the formation of biomolecules are important in understanding the abiotic origin of biomolecules.
Growth of Cu particles on a Cu2O truncated octahedron: tuning of the Cu content for efficient glucose sensing
Authors: Wang Gang , Sun Hong , Ding Lu , Zhou Gang , Wang Zhong-Sheng
Published: August 2015

A simple and versatile hydrothermal method is developed to synthesize Cu–Cu2O, in which Cu particles grow on the surface of a Cu2O truncated octahedron.
Lysozyme adsorption at a silica surface using simulation and experiment: effects of pH on protein layer structure
Authors: Kubiak-Ossowska Karina , Cwieka Monika , Kaczynska Agnieszka , Jachimska Barbara , Mulheran Paul A.
Published: August 2015

MD simulations and experiments (MP-SPR, contact angle and zeta potential measurements) give a comprehensive overview of HEWL adsorption on silica.
Interplay of electrostatics and lipid packing determines the binding of charged polymer coated nanoparticles to model membranes
Authors: Biswas Nupur , Bhattacharya Rupak , Saha Arindam , Jana Nikhil R. , Basu Jaydeep K.
Published: August 2015

Cationic nanoparticles show larger penetration within well-packed zwitterionic lipid bilayer.
Unwilling U–U bonding in U2@C80: cage-driven metal–metal bonds in di-uranium fullerenes
Authors: Foroutan-Nejad Cina , Vícha Jan , Marek Radek , Patzschke Michael , Straka Michal
Published: August 2015

Experimentally known U2@C80has a double ferromagnetic U–U bond. U–U bonding in diuranium fullerenes is fine-tuned by the cage.
In situ spectroscopic investigations of MoOx/Fe2O3 catalysts for the selective oxidation of methanol
Authors: Brookes Catherine , Bowker Michael , Gibson Emma K. , Gianolio Diego , Mohammed Khaled M. H. , Parry Stephen , Rogers Scott M. , Silverwood Ian P. , Wells Peter P.
Published: August 2015

Methoxy adsorbed on MoOx/Fe2O3 surfaces.
Bioactive compounds of Eriocaulon sieboldianum blocking proliferation and inducing apoptosis of HepG2 cells might be involved in Aurora kinase inhibition
Authors: Fan Yanhua , Lu Hongyuan , Ma Hongda , Feng Fan , Hu Xiaolong , Zhang Qiao , Wang Jian , Xu Yongnan , Zhao Qingchun
Published: August 2015

We found that the E. sieboldianum extract and its two active compounds, HPDL and QGGP, could effectively inhibit Aurora kinase and induce apoptosis via p53, MAPKs and mitochondrial apoptotic pathways.
CO2-switchable drying agents
Authors: Boniface Kyle J. , Dykeman Ryan R. , Cormier Alex , Wang Hong-Bo , Mercer Sean M. , Liu Guojun , Cunningham Michael. F. , Jessop Philip G.
Published: August 2015

CO2-switchable desiccants have been prepared and evaluated for the drying of isobutanol.
Oxidative conversion of lignin and lignin model compounds catalyzed by CeO2-supported Pd nanoparticles
Authors: Deng Weiping , Zhang Hongxi , Wu Xuejiao , Li Rongsheng , Zhang Qinghong , Wang Ye
Published: August 2015

Pd/CeO2 efficiently catalyzes the oxidative conversion of 2-phenoxy-1-phenylethanol, a lignin model compound with a β-O-4 linkage, in methanol, producing monomeric aromatics.
Molecular simulations reveal that the long range fluctuations of human DPP III change upon ligand binding
Authors: Tomić A. , Berynskyy M. , Wade R. C. , Tomić S.
Published: August 2015

A range of molecular dynamics simulation techniques were applied to investigate the DPP III conformational landscape and the influence of ligand binding on the protein structure and dynamics.
Convenient analysis of protein modification by chemical blotting with fluorogenic “click” reagents
Authors: Ohata Jun , Vohidov Farrukh , Ball Zachary T.
Published: August 2015

Direct visualization of bioorthogonal alkyne or azide handles using fluorogenic azide–alkyne cycloaddition conducted on the surface of a blot membrane.
HSA carbonylation with methylglyoxal and the binding/release of copper(ii) ions
Authors: Penezić Ana Z. , Jovanović Vesna B. , Pavićević Ivan D. , Aćimović Jelena M. , Mandić Ljuba M.
Published: August 2015

HSA carbonylationin vitro(with MG) andin vivo(diabetes) leads to copper(ii) binding affinity decrease and copper(ii) release from copper–HSA complexes depending mainly on the redox state of the Cys34-SH group.
A novel glutathione-stabilized silver–gold nano-alloy/Cu2+combination as a fluorescent switch probe forl-histidine
Authors: Huang Xiaopeng , Lin Yuejuan , Chen Jiayang , Chen Yaowen , Li Yuqin , Gao Wenhua
Published: August 2015

This paper reports the synthesis of glutathione-stabilized silver–gold nano-alloys and their use as a fluorescent switch probe for the detection ofl-histidine.
Novel hollow all-carbon structures
Authors: Sundholm Dage , Wirz Lukas N. , Schwerdtfeger Peter
Published: August 2015

A new family of cavernous all-carbon structures built from graphyne sheets could be the key to new promising materials.
Cu3Si@Si core–shell nanoparticles synthesized using a solid-state reaction and their performance as anode materials for lithium ion batteries
Authors: Zhou Jianbin , Lin Ning , Han Ying , Zhou Jie , Zhu Yongchun , Du Jin , Qian Yitai
Published: August 2015

Cu3Si@Si core–shell nanoparticles are synthesized by a solid-state reaction and exhibit high electrochemical performance.
Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules
Authors: Tomoshige Shusuke , Naito Mikihiko , Hashimoto Yuichi , Ishikawa Minoru
Published: August 2015

We successfully knocked down HaloTag-fused nuclear proteins in living cells by using protein knockdown technology.
Synthesis of covalent triazine-based frameworks with high CO2 adsorption and selectivity
Authors: Gu Chunyang , Liu Deyu , Huang Wei , Liu Jie , Yang Renqiang
Published: August 2015

PCTF-4 with benzothiadiazole exhibited the highest CO2 uptake (20.5 wt%) and CO2/N2 selectivity (56) among the reported covalent triazine-based frameworks.
Water-soluble and redox-responsive hyperbranched polyether copolymers based on ferrocenyl glycidyl ether
Authors: Alkan Arda , Klein Rebecca , Shylin Sergii I. , Kemmer-Jonas Ulrike , Frey Holger , Wurm Frederik R.
Published: August 2015

Hyperbranched polymers based on glycidol and ferrocenyl glycidyl ether are prepared, characterized, and their redox behavior in water is studied and quantified with Mößbauer spectroscopy.
Nanosheet-assembled MoSe2 and S-doped MoSe2−x nanostructures for superior lithium storage properties and hydrogen evolution reactions
Authors: Yang Yong , Wang Shitong , Zhang Jingchao , Li Haoyi , Tang Zilong , Wang Xun
Published: August 2015

The development of layered molybdenum chalcogenides with largely exposed active sites is receiving intense interest because of their potential applications in energy storage and catalysis.
The isotopic effects of13C-labeled large carbon cage (C70) fullerenes and their formation process
Authors: Wang Chenglong , Ruan Longfei , Chang Xue-Ling , Zhang Xiaoliang , Yang Sheng-Tao , Guo Xihong , Yuan Hui , Guo Cuibin , Shi Weiqun , Sun Baoyun , Zhao Yuliang
Published: August 2015

13C-enriched large carbon cage-based fullerenes were synthesized on a large scale by an arc discharge method.
Antibacterial properties of palladium nanostructures sputtered on polyethylene naphthalate
Authors: Polívková M. , Valová M. , Siegel J. , Rimpelová S. , Hubáček T. , Lyutakov O. , Švorčík V.
Published: August 2015

Scheme of pen processing resulting in “curtain” effect of Pd.
Pt–CeO2/reduced graphene oxide nanocomposite for the electrooxidation of formic acid and formaldehyde
Authors: Habibi Biuck , Delnavaz Nasrin
Published: August 2015

The Pt–CeO2/reduced graphene oxide nanocomposite on the carbon-ceramic electrode (Pt–CeO2/RGO/CCE) was prepared by a two-step electrodeposition process.
Probing the correlation between structure, carrier dynamics and defect states of epitaxial GaN film on (112̄0) sapphire grown by rf-molecular beam epitaxy
Authors: Shibin Krishna T. C. , Aggarwal Neha , Reddy G. Anurag , Dugar Palak , Mishra Monu , Goswami Lalit , Dilawar Nita , Kumar Mahesh , Maurya K. K. , Gupta Govind
Published: August 2015

A systematic study has been performed to correlate structural, optical and electrical properties with defect states in the GaN films grown on a-plane (112̄0) sapphire substrate via rf-plasma molecular beam epitaxy.
Uranium(vi) adsorption from aqueous solutions using poly(vinyl alcohol)/carbon nanotube composites
Authors: Abdeen Z. , Akl Z. F.
Published: August 2015

A series of PVA/MWCNTs hydrogels were synthesized and characterized. Incorruption of MWCNTs into PVA enhanced UO22+ ions removal efficiency compared to the PVA only. UO22+ adsorption process on PVA/MWCNTs hydrogels was exothermic and spontaneous.
Palladium nanoparticle functionalized graphene nanosheets for Li–O2batteries: enhanced performance by tailoring the morphology of the discharge product
Authors: Wang Liang Jun , Zhang Jian , Zhao Xiao , Xu Lei Lei , Lyu Zhi Yang , Lai Min , Chen Wei
Published: August 2015

The Li–O2battery with palladium functionalized graphene nanosheets cathode exhibits enhanced discharge capacity and improved ORR/OER performance through tailoring the morphology of discharge product.
Synthesis and characterization of hole-transporting star-shaped carbazolyl truxene derivatives
Authors: Raksasorn Danusorn , Namuangruk Supawadee , Prachumrak Narid , Sudyoadsuk Taweesak , Promarak Vinich , Sukwattanasinitt Mongkol , Rashatasakhon Paitoon
Published: August 2015

Two star-shaped carbazolyl truxene derivatives (1 and 2) are synthesized and characterized. The applications of both compounds as hole-transporting materials in OLED devices are demonstrated.
Ni(0)–Cu(i): a powerful combo catalyst for simultaneous coupling and cleavage of the C–N bond with cyclization to valuable amide-based pyrroles and 4-pyridones
Authors: Roy Dipanwita , Sarkar Satinath , Laha Radha M. , Pramanik Nabyendu , Maiti Dilip K.
Published: August 2015

We demonstrate unprecedented Ni(0)–Cu(i) combo catalysis for sequential bond activated domino N–C/C–C coupled annulation with N–C bond cleavage to afford valuable amide-based polysubstituted pyrroles and 4-pyridones selectively from β-ketoanilides.
AO-resistant shape memory polyimide/silica composites with excellent thermal stability and mechanical properties
Authors: Yang Zenghui , Wang Qihua , Bai Yongkang , Wang Tingmei
Published: August 2015

Shape memory polyimide/silica composite films show AO-resistant performance, good thermal stability and mechanical properties.
Synthesis and electrochemical performance of Li4Ti5O12/TiO2/C nanocrystallines for high-rate lithium ion batteries
Authors: Zhu Wenjun , Yang Hui , Zhang Wenkui , Huang Hui , Tao Xinyong , Xia Yang , Gan Yongping , Guo Xingzhong
Published: August 2015

A Li4Ti5O12/TiO2/carbon (Li4Ti5O12/TiO2/C) nanocrystalline composite has been successfully synthesized by a facile sol–gel method and subsequent calcination treatment.
A sandwich electrochemical immunoassay for Salmonella pullorum and Salmonella gallinarum based on a AuNPs/SiO2/Fe3O4adsorbing antibody and 4 channel screen printed carbon electrode electrodeposited gold nanoparticles
Authors: Fei Jianfeng , Dou Wenchao , Zhao Guangying
Published: August 2015

A: The synthesis of Fe3O4/SiO2–SH; B: AuNPs and the Ab1link with Fe3O4/SiO2–SH; C: functions of IMB for antigen enrichment and separation from the sample, and HRP-antibody for the immunoreaction; D: the principle of the electrochemical detection.
Electrochemical performances of cobalt oxide–carbon nanotubes electrodes via different methods as negative material for alkaline rechargeable batteries
Authors: Xu Yanan , Dong Yanyin , Wang Xiaofeng , Wang Yijing , Jiao Lifang , Yuan Huatang , Li Jing
Published: August 2015

Co3O4/CNTs samples are synthesized via different methods and investigated as negative materials for alkaline rechargeable batteries for the first time.
Study of the structure-activity relationship of flavonoids based on their interaction with human serum albumin
Authors: Tu Bao , Chen Zhi-Feng , Liu Zhi-Juan , Li Rong-Rong , Ouyang Yu , Hu Yan-Jun
Published: August 2015

The influence of functional groups on the interaction has been studied detailed here; fluorescence quenching degrees and the conformation change are considered through multiple methods; molecular docking has been introduced to verify related results.
Understanding the molecular mechanism in a regiospecific [3 + 2] cycloaddition reaction including C–O and C–S interactions: an ELF topological analysis
Authors: Emamian Saeedreza
Published: August 2015

Regiospecific 32CA reaction of nitrone 10 toward thioketone 11 takes place via a non-concerted one-step mechanism confirmed by ELF analysis.
Kinetic study of the OH and Cl-initiated oxidation, lifetimes and atmospheric acceptability indices of three halogenated ethenes
Authors: Barrera Javier A. , Dalmasso Pablo R. , Aranguren Abrate Juan P. , Taccone Raúl A. , Lane Silvia I.
Published: August 2015

First relative kinetic study for the OH/Cl reactions with three chloro-fluoro-ethenes at room-temperature and atmospheric pressure and environmental acceptability.
Manipulating carriers' spin polarization in the Heusler alloy Mn2CoAl
Authors: Zhou Jian , Sa Baisheng , Sun Zhimei , Si Chen , Ahuja Rajeev
Published: August 2015

We report that complete spin polarization and controllable spin polarization of carriers can be simultaneously realized in the Heusler alloy Mn2CoAl simply by applying external pressures based on first-principles studies.
In vivo biodistribution and toxicity of Gd2O3:Eu3+ nanotubes in mice after intraperitoneal injection
Authors: Liu Huifang , Jia Guang , Chen Shizhu , Ma Huanyun , Zhao Yanyan , Wang Jianguo , Zhang Cuimiao , Wang Shuxian , Zhang Jinchao
Published: August 2015

To better understand the potential impact of Gd2O3:Eu3+ nanotubes on human health, we investigated their biodistribution, subacute toxicity, and hepatic injury in mice under different dosages (4.0, 40.0, and 400.0 mg kg−1).
Synthesis of benzofulvenes through chemoselective Sonogashira and Barluenga couplings of ortho ethynyl-N-tosylhydrazones and cycloisomerization
Authors: Aziz Jessy , Brion Jean-Daniel , Alami Mouad , Hamze Abdallah
Published: August 2015

Chemoselective synthesis oforthoethynylhydrazones7derived from 2-iodoacetophenoneviaa Sonogashira coupling is reported for the first time.
Improving the electrochemical properties of polyamide 6/polyaniline electrospun nanofibers by surface modification with ZnO nanoparticles
Authors: Andre Rafaela S. , Pavinatto Adriana , Mercante Luiza A. , Paris Elaine C. , Mattoso Luiz H. C. , Correa Daniel S.
Published: August 2015

ZnO nanoparticles adsorbed onto electrospun nanofiber surfaces improve the electron transfer kinetics and increase the electrode electroactive area. The modified electrodes can be a potential platform for electrochemical applications.
Human hair-derived nitrogen and sulfur co-doped porous carbon materials for gas adsorption
Authors: Zhao Zhi-Qiang , Xiao Pei-Wen , Zhao Li , Liu Yuwen , Han Bao-Hang
Published: August 2015

Nitrogen and sulfur co-doped porous carbon materials derived from human hair exhibit good performance in gas adsorption.
Effects of terminal group and chain length on temperature-responsive chromatography utilizing poly(N-isopropylacrylamide) synthesized via RAFT polymerization
Authors: Hiruta Yuki , Nagumo Yuhei , Miki Atsushi , Okano Teruo , Kanazawa Hideko
Published: August 2015

Even using the same homo poly(N-isopropylacrylamide) immobilized silica beads as stationary phases, terminal functional group and chain length significantly affected temperature-dependent elution behavior of steroids.
A greener approach towards double heteroarylation of N, O and S nucleophiles: synthesis of bioactive polynuclear fused N-heteroarenes
Authors: Nikumbh Satish P. , Raghunadh Akula , Murthy V. Narayana , Jinkala Rajesh , Joseph Suju C. , Murthy Y. L. N. , Prasad Bagineni , Pal Manojit
Published: August 2015

We report first general and common strategy for double heteroarylation of N, O and S nucleophiles leading to polynuclear N-heteroarenes.
Dual-responsive polypseudorotaxanes based on block-selected inclusion between polyethylene-block-poly(ethylene glycol) diblock copolymers and 1,4-diethoxypillar[5]arene
Authors: Chen Jianzhuang , Li Nan , Gao Yongping , Sun Fugen , He Jianping , Li Yongsheng
Published: August 2015

Two novel dual-responsive polypseudorotaxanes are successfully constructedviathe selective recognition of the PE block of PE-b-PEG by 1,4-diethoxypillar[5]arene.
Oxygen reduction reaction induced pH-responsive chemo-mechanical hydrogel actuators
Authors: Yu Cunjiang , Yuan Peixi , Erickson Evan M. , Daly Christopher M. , Rogers John A. , Nuzzo Ralph G.
Published: August 2015

We describe and characterize elementary designs for electrochemical micro- and macro-scale chemomechanical hydrogel actuators.
Honeycomb-like porous iron fluoride hybrid nanostructures: excellent Li-storage properties and investigation of the multi-electron reversible conversion reaction mechanism
Authors: Song Huawei , Yang Gongzheng , Cui Hao , Wang Chengxin
Published: August 2015

Good specific energy/power performance and fast kinetic processes are simultaneously realized in a honeycomb-like porous iron fluoride hybrid nanostructure.
Co-MOF as a sacrificial template: manifesting a new Co3O4/TiO2 system with a p–n heterojunction for photocatalytic hydrogen evolution
Authors: Bala Sukhen , Mondal Indranil , Goswami Arijit , Pal Ujjwal , Mondal Raju
Published: August 2015

A MOF derived approach to synthesize a Co3O4/TiO2 heterostructure with p-type spinel-Co3O4 and n-type anatase TiO2 for enhanced photocatalytic H2 evolution by water splitting.
Novel dual-petal nanostructured WS2@MoS2 with enhanced photocatalytic performance and a comprehensive first-principles investigation
Authors: Li Honglin , Yu Ke , Li Chao , Guo Bangjun , Lei Xiang , Fu Hao , Zhu Ziqiang
Published: August 2015

A prominent enhanced photocatalytic activity of the WS2@MoS2 heterojunction was obtained. The first-principles calculation showed that a well-defined type-II staggered energy band was formed for the composite structure.
Eco-friendly one-pot synthesis of ultradispersed TiO2 nanocrystals/graphene nanocomposites with high photocatalytic activity for dye degradation
Authors: Shao Penghui , Tian Jiayu , Shi Wenxin , Gao Shanshan , Cui Fuyi
Published: August 2015

We report an eco-friendly one-pot hydrothermal synthesis of ultrafine TiO2 nanocrystals (∼4.01 nm) homogeneously dispersed on the entire surface of graphene.
Silk fibroin hydroxyapatite composite thermal stabilisation of carbonic anhydrase
Authors: Lopes J. H. , Guilhou M. , Marelli B. , Omenetto F. G. , Kaplan D. L. , Barralet J. E. , Merle G.
Published: August 2015

Hybrid organic–inorganic micro-particles have been prepared by a phosphate ultrasound treatment to immobilise carbonic anhydrase. These hierarchical structures show a noteworthy thermal stability in alkanolamine solvent used for CO2 sequestration and allow an easy separation and re-use.
Photo-assisted water splitting with bipolar membrane induced pH gradients for practical solar fuel devices
Authors: Vermaas David A. , Sassenburg Mark , Smith Wilson A.
Published: August 2015

A bipolar membrane maintains a pH gradient for solar driven water splitting with an acidic cathodic environment and neutral or alkaline anodic environment.
Ambient pressure dried graphene aerogels with superelasticity and multifunctionality
Authors: Yang Hongsheng , Zhang Tongping , Jiang Min , Duan Yongxin , Zhang Jianming
Published: August 2015

By an ice-template method, in this work we realized an ambient pressure dried graphene aerogel (ADGA) with superelasticity and multifunctionality by using ordinary instruments.
Injection-molded hydroxyapatite/polyethylene bone-analogue biocomposites via structure manipulation
Authors: Wang Ze-Pu , Huang Yan-Fei , Xu Jia-Zhuang , Niu Ben , Zhang Xiao-Liang , Zhong Gan-Ji , Xu Ling , Li Zhong-Ming
Published: August 2015

By means of an OSIM technique, anisotropic biomimetic, high-performance HA/HDPE biocomposites were obtained.
Inherently fluorescent and porous zirconia colloids: preparation, characterization and drug adsorption studies
Authors: Naszályi Nagy L. , Mihály J. , Polyak A. , Debreczeni B. , Császár B. , Szigyártó I. Cs. , Wacha A. , Czégény Zs. , Jakab E. , Klébert Sz. , Drotár E. , Dabasi G. , Bóta A. , Balogh L. , Kiss É.
Published: August 2015

Adsorption of drug molecules onto the zirconia surface.
Swim bladder collagen forms hydrogel with macroscopic superstructure by diffusion induced fast gelation
Authors: Mredha Md. Tariful Islam , Zhang Xi , Nonoyama Takayuki , Nakajima Tasuku , Kurokawa Takayuki , Takagi Yasuaki , Gong Jian Ping
Published: August 2015

Type I collagen extracted from the swim bladder of Bester sturgeon forms an oriented hydrogel with mechanical and thermal stability by diffusion induced fast gelation.
Hyaluronic acid and neural stem cells: implications for biomaterial design
Authors: Khaing Zin Z. , Seidlits Stephanie K.
Published: August 2015

While in the past hyaluronic acid (HA) was considered a passive structural component, research over the past few decades has revealed its diverse and complex biological functions resulting in a major ideological shift. This review describes recent advances in biological interactions of HA with neural stem cells, with a focus on leveraging these interactions to develop advanced biomaterials that aid regeneration of the central nervous system.
Programming the assembly of gold nanoparticles on graphene oxide sheets using DNA
Authors: Heuer-Jungemann Amelie , Kiessling Liam , Stratakis Emmanuel , Kymakis Emmanuel , El-Sagheer Afaf H. , Brown Tom , Kanaras Antonios G.
Published: August 2015

Programmed and covalent nanoparticle attachment onto graphene oxide using DNA click ligation chemistry.
Correction: Ternary donor–acceptor phosphine oxide hosts with peculiar high energy gap for efficient blue electroluminescence
Authors: Sun Mingzhi , Zhu Liping , Kan Wenjing , Wei Ying , Ma Dongge , Fan Xuefeng , Huang Wei , Xu Hui
Published: August 2015

Correction for ‘Ternary donor–acceptor phosphine oxide hosts with peculiar high energy gap for efficient blue electroluminescence’ by Mingzhi Sun et al., J. Mater. Chem. C, 2015, DOI: 10.1039/c5tc02029h.
Communication Programming Implications for Individuals With Genetic Causes of Severe Disability and Visual Impairment
Authors: Bruce Susan M. , Brum Chris , Nannemann Allison
Published: August 2015

This article discusses genetic syndromes that are etiologies of severe disabilities that include the characteristic of visual impairment. Information provided about refractive errors, field loss, cortical visual impairment, and ocular issues is intended to support the practitioner outside the field of visual impairment to collaborate with the teacher of students with visual impairments (TVI). This article provides an overview of the responsibilities of the TVI who can advise others about appropriate enlargement of materials, positioning for optimal use of functional vision, and adaptations to lessons such as the individualized daily schedule. Additionally, the TVI is familiar with instructional strategies to support the use of functional vision and to develop tactile skills. This article concludes with a discussion of the importance of interprofessional collaboration.
Interferometric RotoSAR
Authors: Pieraccini M. , Papi F. , Rocchio S.
Published: August 2015

A synthetic aperture radar (SAR) system (RotoSAR) is proposed based on a radar head fixed at a rotating arm with antennas aimed in the direction orthogonal to the plane of rotation. This system is able to provide SAR images and the three components of displacement vectors of the targets in the field of view.
Additive manufacturing of 3D substrate integrated waveguide components
Authors: Moscato S. , Bahr R. , Le T. , Pasian M. , Bozzi M. , Perregrini L. , Tentzeris M.M.
Published: August 2015

The implementation of fully three‐dimensional (3D) substrate integrated waveguide (SIW) components by using an additive manufacturing technique is demonstrated for the first time. In particular, a 3D printing process based on the t‐glase filament has been adopted. 3D printing allows for the manufacturing of very complex shapes in a few hours, thus leading to a one‐day prototyping time for microwave components. To characterise the electromagnetic properties of the 3D printed material, a microstrip lines technique has been adopted. To fully demonstrate the potential of the proposed fabrication process, a SIW cavity resonator and a 3D SIW interconnect with four E‐plane bends have been fabricated and tested.