bluuebunny/crossref_metadata_2025 huggingface dataset:
Definition and measurement of post-COVID-19 conditions in real-world practice: a global systematic literature review
Authors: Yang Jingyan , Markus Kristen , Andersen Kathleen Michelle , Rudolph Abby E , McGrath Leah J , Nguyen Jennifer L , Kyaw Moe H , Whittle Isabelle , Blazos Vasileios , Heron Louise , Spinardi Julia Regazzini
Published: January 2024

Post-COVID-19 conditions (PCC) is an umbrella term that encompasses a range of signs, symptoms and conditions present weeks after the acute phase of a SARS-CoV-2 infection. This systematic literature review summarises the heterogeneous methodology used to measure PCC across real-world studies and highlights trends by region, age group, PCC follow-up period and data source.

Methods

Medline, EMBASE and the Cochrane Library were searched and supplemented with conference and grey literature searches. Eligible studies included individuals with (1) PCC or (2) a positive SARS-CoV-2 test or COVID-19 diagnosis who were followed over time. Included studies were published in English between 1 January 2020 and 14 November 2022.

Findings

Of 291 publications included, 175 (60%) followed individuals with confirmed COVID-19 over time for PCC and 116 (40%) used a prespecified PCC definition. There was substantial heterogeneity in study design, geography, age group, PCC conditions/symptoms assessed and their classification and duration of follow-up. Among studies using a prespecified PCC definition, author-defined criteria (51%) were more common than criteria recommended by major public health organisations (19%). Measurement periods for PCC outcomes from date of acute COVID-19 test were primarily 3 to <6 months (39.2%), followed by 6 to <12 months (27.5%) and <3 months (22.9%). When classified by organ/system, constitutional-related PCC were the most frequently assessed in adult (86%) and paediatric (87%) populations. Within constitutional symptoms, fatigue was most frequently assessed in adult (91.6%) and paediatric (95.0%) populations, followed by fever/chills (37.9% and 55%, respectively).

Conclusions

PCC definitions are heterogenous across real-world studies, which limits reliable comparisons between studies. However, some similarities were observed in terms of the most frequently measured PCC-associated symptoms/conditions, which may aid clinical management of patients with PCC.

CRD42022376111.
Predictors of adverse outcomes in elders hospitalised for isolated orthopaedic trauma: a multicentre cohort study
Authors: Isaac Chartelin Jean , Moore Lynne , Bérubé Mélanie , Belzile Étienne , Malo Christian , Giroux Marianne , Belcaid Amina , Abiala Godwill , Trépanier David , Émond Marcel , Dionne Clermont E
Published: January 2024

Background

Patients >64 years of age now represent more than 51% of injury hospitalisations in Canada. The tools used to identify older patients who could benefit the most from an interdisciplinary approach include complex parameters difficult to collect in the ED, which suggests that better tools with higher accuracy and using items that can be derived from routinely collected data are needed. We aimed to identify variables that are associated with adverse outcomes in older patients admitted to a trauma centre for an isolated orthopaedic injury.

Methods

We conducted a multicentre retrospective cohort study between 1 April 2013 and 31 March 2019 on older patients hospitalised with a primary diagnosis of isolated orthopaedic injury (n=19 928). Data were extracted from the provincial trauma registry (Registre des traumatismes du Québec). We used multilevel logistic regression to estimate the associations between potential predictors and adverse outcomes (extended length of stay, mortality, complications, unplanned readmission and adverse discharge destination).

Results

Increasing age, male sex, specific comorbidities, type of orthopaedic injuries, increasing number of comorbidities, severe orthopaedic injury, head injuries and admission in the year before the injury were all significant predictors of adverse outcomes.

Conclusion

We identified eight predictors of adverse outcomes in patients >64 years of age admitted to a trauma centre for orthopaedic injury. These variables could eventually be used to develop a clinical decision rule to identify elders who may benefit the most from interdisciplinary care.
Using an artificial intelligence software improves emergency medicine physician intracranial haemorrhage detection to radiologist levels
Authors: Warman Pranav , Warman Anmol , Warman Roshan , Degnan Andrew , Blickman Johan , Smith David , McHale Paul , Coburn Zachary , McCormick Sean , Chowdhary Varun , Dash Dev , Sangal Rohit , Vadhan Jason , Bueso Tulio , Windisch Thomas , Neves Gabriel
Published: January 2024

Background

Tools to increase the turnaround speed and accuracy of imaging reports could positively influence ED logistics. The Caire ICH is an artificial intelligence (AI) software developed for ED physicians to recognise intracranial haemorrhages (ICHs) on non-contrast enhanced cranial CT scans to manage the clinical care of these patients in a timelier fashion.

Methods

A dataset of 532 non-contrast cranial CT scans was reviewed by five board-certified emergency physicians (EPs) with an average of 14.8 years of practice experience. The scans were labelled in random order for the presence or absence of an ICH. If an ICH was detected, the reader further labelled all subtypes present (ie, epidural, subdural, subarachnoid, intraparenchymal and/or intraventricular haemorrhage). After a washout period, the five EPs reviewed again the scans individually with the assistance of Caire ICH. The mean accuracy of the EP readings with AI assistance was compared with the mean accuracy of three general radiologists reading the films individually. The final diagnosis (ie, ground truth) was adjudicated by a consensus of the radiologists after their individual readings.

Results

Mean EP reader accuracy significantly increased by 6.20% (95% CI for the difference 5.10%–7.29%; p=0.0092) when using Caire ICH to detect an ICH. Mean accuracy of the EP cohort in detecting an ICH using Caire ICH was found to be more accurate than the radiologist cohort prior to discussion; this difference, however, was not statistically significant.

Conclusion

The Caire ICH software significantly improved the accuracy and sensitivity of detecting an ICH by the EP to a level comparable to general radiologists. Further prospective research with larger numbers will be needed to understand the impact of Caire ICH on ED logistics and patient outcomes.
Epidemiology of work-related fall injuries resulting in hospitalisation: individual and work risk factors and severity
Authors: Wah Win , Berecki-Gisolf Janneke , Walker-Bone Karen
Published: January 2024

Objectives

Injuries at work are common and costly for individuals and employers. A common mechanism of workplace injury is through falls, but there have been few epidemiological studies of risk factors. This study aimed to identify patient, work and injury factors associated with injuries causing hospitalisation after falling at work in Victoria, Australia.

Methods

Data came from work-related hospitalised injury admissions, identified by International Classification of Diseases and Related Health Problems, Tenth Revision Australian Modification codes and compensation status, from Victorian Admitted Episodes Dataset between 1 July 2017 and 30 June 2022. Multivariate logistic regression analyses were conducted to identify factors associated with same-level falls and falls from height.

Results

This study included 42 176 work-related injury admissions: 8669 (20.6%) fall injuries and 33 507 (79.4%) other injuries. Rates of high falls were more common in males than females (0.44 (95% CI: 0.43, 0.46) vs 0.08 (0.08, 0.09) admissions per 1000 employed), while same-level falls were more common in females than males (0.21 (0.20, 0.22) vs 0.18 (0.17, 0.18)). Patients with same-level fall injuries, relative to all other work injuries, were more likely to be older women, and have at least one chronic condition; falls from height were associated with male sex and construction work and more likely to result in intracranial, internal organ injuries and fractures and longer hospital stay than non-fall injuries.

Conclusion

Work-related falls were common and relatively severe. Same-level falls are relatively likely to occur in older women, the fastest-growing workplace demographic, and therefore the incidence is expected to increase. Comorbidities are an important fall risk factor. Employers could consider industry-relevant high and same-level fall prevention strategies for reducing the workplace injury burden.
Diurnal production of cortisol and prediction of treatment response in rheumatoid arthritis: a 6-month, real-life prospective cohort study
Authors: Yavropoulou Maria P , Filippa Maria G , Vlachogiannis Nikolaos I , Fragoulis George E , Laskari Katerina , Mantzou Aimilia , Panopoulos Stylianos , Fanouriakis Antonis , Bournia Vasiliki-Kalliopi , Evangelatos Gerasimos , Papapanagiotou Aggeliki , Tektonidou Maria G , Chrousos George P , Sfikakis Petros P
Published: January 2024

Objectives

A reduced adrenal reserve-associated cortisol production relative to the enhanced needs of chronic inflammation (disproportion principle) has been observed in rheumatoid arthritis (RA). We examined the possible clinical value of diurnal cortisol measurements in active RA on treatment response prediction.

Methods

Diurnal cortisol production (measured at: 08–12:00/18:00–22:00) was assessed by electrochemiluminescence immunoassay in 28 consecutive patients with moderately/highly active RA, as well as 3 and 6 months after treatment initiation or/escalation. Twenty-eight COVID-19 patients and 28 age-matched healthy individuals (HC) served as controls.

Results

Saliva diurnal cortisol production in patients with RA was similar to that of HC, despite 12-fold higher serum C reactive protein (CRP) levels, and lower than COVID-19 patients (area under the curve: RA: 87.0±37.6 vs COVID-19: 146.7±14.3, p<0.001), having similarly high CRP. Moreover, a disturbed circadian cortisol rhythm at baseline was evident in 15 of 28 of patients with RA vs 4 of 28 and 20 of 28 of HC and COVID-19 patients, respectively. Treatment-induced minimal disease activity (MDA) at 6 months was achieved by 16 of 28 patients. Despite comparable demographics and clinical characteristics at baseline, non-MDA patients had lower baseline morning cortisol and higher adrenocorticotropic hormone (ACTH) levels compared with patients on MDA (cortisol: 10.9±4.0 vs 18.4±8.2 nmol/L, respectively, p=0.005 and ACTH: 4.8±3.3 vs 2.4±0.4 pmol/L, respectively, p=0.047). Baseline morning cortisol <13.9 nmol/L predicted non-MDA at 6 months (75% sensitivity, 92% specificity, p=0.006). Prospective measurements revealed that individualised diurnal cortisol production remained largely unchanged from baseline to 3 and 6 months.

Conclusions

An impaired adrenal reserve is present in patients with RA. Further studies to confirm that assessment of diurnal cortisol production may be useful in guiding treatment decisions and/or predicting treatment response in RA are warranted.

Trial registration number

NCT05671627.
A new state-dependent constitutive model for cyclic thermo-mechanical behaviour of unsaturated vegetated soil
Authors: Ng C.W.W. , Zhang Q. , Zhang S. , Lau S.Y. , Guo H. , Li Z.
Published: January 2024

Climate change has resulted in increasing attention being paid to the effects of temperature and humidity on vegetated soil. However, existing constitutive models rarely investigate the thermo-mechanical behaviour, such as the accumulation of plastic strain under non-isothermal conditions, of unsaturated vegetated soil. To address this issue, this study developed a comprehensive constitutive model by adopting state-dependent dilatancy in conjugation with loading, memory, and bounding surfaces. Moreover, root-induced hardening due to pore occupancy and internal bonding is modelled with dependence on the root volume ratio. The performance of this newly developed constitutive model is then evaluated using previous laboratory element tests. Comparisons between the computed and measured results reveal that the model is capable of capturing variations in soil state at a range of temperatures, suctions, and root volume ratios. The shearing behaviour of vegetated soil, especially its volumetric response, is well predicted by the model, as confirmed by comparing it with triaxial compression test results. Moreover, the model predicts that the accumulated volumetric strain of unsaturated vegetated soil (0.2%) is significantly less than saturated bare soil (1.1%) after four thermal cycles. These computed results imply that vegetation can mitigate the effects of climate change on soil through both transpiration-induced suction and mechanical reinforcement.
A bounding-surface-based cyclic “p–y+M–θ” model for unified description of laterally loaded piles with different failure modes in clay
Authors: Hong Yi , Chen Xuanyu , Wang Lizhong , Wang Lilin , He Ben
Published: January 2024

The increasing turbine sizes have necessitated monopiles in soft clay to have larger diameter and rigidity, from early design of flexible piles to recent semi-rigid piles, with future anticipating rigid piles. Existing few cyclic soil–pile interaction models are developed for flexible pile associated with full-flow failure (above the rotation point, RP), with little attention paid to semi-rigid and rigid piles involving rotational-shear failure (below RP). This study aims to unify the description of piles with varying rigidity by proposing a cyclic two-spring model, where lateral resistances above and below RP are described with cyclic p–y and M– θ springs, respectively. It naturally recovers to a cyclic p–y model for flexible piles. The cyclic p–y and M– θ formulations are developed within the bounding-surface plasticity framework, based on numerical results of cyclic soil–pile interaction concerning full-flow and rotational-shear mechanisms, respectively. These numerical analyses are performed using a cyclic plasticity clay model developed and implemented numerically in this study. The cyclic “ p–y+M– θ” model quantitatively reproduces experimental results of cyclic shakedown and ratcheting for flexible, semi-rigid, and rigid piles. Ignorance of the M–θ spring could underestimate cyclic resistance of rigid piles by 25%, suggesting the model’s merit in reducing conservatism for monopiles in feature designs.
A new mathematical model for the estimation of shear modulus for unsaturated compacted soils
Authors: Zhai Qian , Zhang Ruize , Rahardjo Harianto , Satyanaga Alfrendo , Dai Guoliang , Gong Weimin , Zhao Xueliang , Chua Yuan Shen
Published: January 2024

Small-strain shear modulus ( G) is an essential parameter for many geotechnical analyses. Most of shallow foundations are constructed in an unsaturated soil and the shear modulus of the unsaturated soil fluctuates because of the precipitation, evaporation, and rising of ground water table. In this paper, a new mathematical model is proposed for the estimation of the shear modulus function, Gunsat, which defines the relationship between small-strain modulus of unsaturated soil and matric suction. In the proposed model, the soil-water characteristic curve in the form of the degree of saturation is used as the input information. There are additional two parameters named n and C, which can be calibrated with the experimental data, are adopted in the proposed model. The estimated results show good agreement with the experimental data from literature. The proposed method can be used to track the tendency of Gunsat and minimize the data points from the laboratory tests.
Evaluation of human-induced vibration in floors of modular hospitals
Authors: Saini Rahul , Sadeghian Vahid , Erochko Jeffrey , Lau David
Published: January 2024

Construction of modular hospitals has gained significant attention since the global pandemic. One important design requirement for hospitals that is critical for their safe operation is to control floor vibration. Floors in modular buildings are often more prone to vibration because they are lightweight and less restrained. This study first presents a standardized design layout for modular hospitals developed based on Canadian code requirements. Then, the human-induced vibration of various floor systems designed for this sample modular hospital is investigated using different analysis methods including a new method developed by the authors. It is found that conventional floor designs may not be suitable for modular hospitals considering the strict vibration limits for hospitals and the need for lightweight construction. Using detailed finite element analysis, it is shown that the proposed method can accurately predict the vibration response of various floors including those that have frequencies well beyond the application range of existing design methods.
QUANTIFYING THE COVID-19 SHOCK IN CRYPTOCURRENCIES
Authors: FERNANDES LEONARDO H. S. , SILVA JOSÉ W. L. , ARAUJO FERNANDO H. A. , BARIVIERA AURELIO F.
Published: January 2024

This paper sheds light on the changes suffered in cryptocurrencies due to the COVID-19 shock through a nonlinear cross-correlations and similarity perspective. We have collected daily price and volume data for the seven largest cryptocurrencies considering trade volume and market capitalization. For both attributes (price and volume), we calculate their volatility and compute the Multifractal Detrended Cross-Correlations (MF-DCCA) to estimate the complexity parameters that describe the degree of multifractality of the underlying process. We detect (before and during COVID-19) a standard multifractal behavior for these volatility time series pairs and an overall persistent long-term correlation. However, multifractality for price volatility time series pairs displays more persistent behavior than the volume volatility time series pairs. From a financial perspective, it reveals that the volatility time series pairs for the price are marked by an increase in the nonlinear cross-correlations excluding the pair Bitcoin versus Dogecoin [Formula: see text]. At the same time, all volatility time series pairs considering the volume attribute are marked by a decrease in the nonlinear cross-correlations. The K-means technique indicates that these volatility time series for the price attribute were resilient to the shock of COVID-19. While for these volatility time series for the volume attribute, we find that the COVID-19 shock drove changes in cryptocurrency groups.
A time-space SIR model for disease spread across two regions: Analysis and numerical simulations
Authors: Elamraoui O. , Essoufi E. H. , Rahnaoui H. , Zafrar A.
Published: January 2024

This paper handles with a time-space SIR model in two regions which have a common interface. The model is defined as coupled reaction–diffusion system with a robin boundary in interface to predict the immigration between the two regions. As known, the immigration has an influence on the spread of disease, this is caused by immigrants who could carry the disease from their areas to other places. For this reason, this paper deals with the existence of solutions to SIR model with disease spread between different regions by the Fadeo–Galerkin method and validate this result by the numerical simulations.
Electronic and Optical Properties of Mn-Doped HgSe Topological Insulator for Spintronic Devices
Authors: Habibes Nour El Houda , Boukortt Abdelkader , Meskine Said , Benbedra Abdesamed , Mamouni Yousra , Bennacer Hamza
Published: January 2024

HgSe is a Mercury chalcogenide material of the HgX family (where X = S, Se, Te) which crystallises in the zincblende crystal phase. The electronic band structure of HgSe is indicative of a new state of matter in the condensed phase that is of great interest for fundamental physics and possibly new applications. This paper reports ab-initio calculations of the structural, electronic, magnetic, and optical properties of zincblende Mercury selenide (HgSe) doped with manganese (Mn) in the inter sites HgMnxSe, with x = 0, 0.058, and 0.117, using the framework of spin-polarized density functional theory (SP-DFT). The aim of our investigation is to discuss the different properties of this doped material in order to improve the promising new domain of spintronics with topological systems. Both the GGA + U + mBJ approach and spin–orbit coupling (SOC) are used for band structure calculations and density of states. The results show a nontrivial topological semimetal order for HgSe and a ferromagnetic topological and metallic behaviour for HgMnxSe. The frequency response of optical properties shows interesting characteristics. Furthermore, the variation with concentration x of the critical point for each of the optical parameters is similar to that of the inverted band gap.
Investigation on Germanium Transistors with HfOx-Based Gate Stacks for CMOS Operations
Authors: Hong Tzu-Chieh , Su Chun-Jung , Lee Yao-Jen , Li Yiming , Samukawa Seiji , Chao Tien-Sheng
Published: January 2024

Germanium (Ge) FinFETs with HfOx-based gate stacks are fabricated to study the CMOS applications. To evaluate the logic circuit operation, the associated CMOS inverters are characterized. Compared to the HfO2, the Hf0.5Zr0.5Ox (HZO) gate stack provides higher drive currents and more symmetric Vth behaviors, which should be associated with the polarization effect. Through cyclic voltage transfer characteristic (VTC) operation and systematical analysis, it is found that both polarization and charge trapping in the gate stack impact the device characteristics. The HZO devices show a negative VTC shift with cycling, while the HfO2 devices reveal a positive shift. This opposite VTC behavior for both gate stack schemes indicates that the interaction of interface states and dipoles significantly influences the device operation. The results revealed in this work present a comprehensive understanding of HfOx-based device optimization.
An AlGaN-GaN HEMT with p-GaN Extended Gate for Improvements on Current Dispersion and Breakdown Characteristics
Authors: Sriramadasu Krishna Sai , Hsin Yue-Ming
Published: January 2024

This study introduces a novel p-GaN/AlGaN/GaN heterostructure wafer, implementing a unique p-type GaN gate AlGaN/GaN HEMT configuration. In this design, the p-GaN region extends toward the drain, eliminating the need for a gate electrode. This innovation significantly enhances the HEMT’s performance, with a 45.2% increase in breakdown voltage (BV) and a 17% higher threshold voltage (VTH) compared to conventional p-GaN gate HEMTs. The extended gate design redistributes the electric field, acting as a field plate to elevate the breakdown voltage. Furthermore, the proposed device, by reducing 17.4% of the saturation current without increasing the on-resistance, possibly offers improved short-circuit capability.
Evaluation of Heart Substructures as a Function of Dose and Radiation-Induced Toxicities in Left-Sided Breast Cancer Radiotherapy
Authors: Costin Ioana-Claudia , Marcu Loredana G.
Published: January 2024

Background. A group of cardiopathies (ischemic, arrhythmic, and pericardial cardiac events) were shown to be associated with doses received by heart substructures following radiotherapy, alerting about the importance of dosimetric evaluation of cardiac structures besides the heart. The aim of this study was to assess the dosimetry of heart and heart substructures of left-sided breast cancer radiotherapy to evaluate possible radiation-induced complications. Methods and Materials. The study enrolled 20 patients treated with 3D-conformal radiotherapy (3DCRT), while intensity-modulated (IMRT) and volumetric-modulated arc radiotherapy (VMAT) plans were simulated for comparative purposes. The organs at risk (OARs) of interest were the heart, ascending aorta, descending aorta, left ventricle, left atrium, right ventricle, right atrium, superior vena cava, inferior vena cava, and pulmonary artery. Results. The percentage of left ventricle included in the radiation field was >5% for all plans (8.92% 3DCRT, 8.30% IMRT, and 6.84% VMAT). A strong correlation between mean heart dose and the percentage of left ventricle overlapping with the radiation fields was observed in 3DCRT (r = 0.784) and IMRT (r = 0.755) plans, and a moderate correlation was shown between tumor volume and the percentage of left ventricle included in the radiation field for all plans. A moderate correlation was observed between body mass index and cardiac structures for the mean dose to the right ventricle (r = 0.640) in conformal plans and V5 of heart (r = 0.528) and left ventricle (r = 0.669) in volumetric-modulated plans. Additionally, moderate to strong correlations were found between maximum heart distance and heart dose in both conformal and modulated plans. Conclusions. Considering possible occurrences of cardiac events during or postradiotherapy, monitoring the heart and its substructures and setting dosimetric thresholds for healthy tissues must be a priority to achieve a personalized and effective treatment.
Investigation of the Potential Targets and Mechanism Actions of Berberine in the Treatment of Pulpitis Based on Bioinformatics Analysis
Authors: Xin Bingchang , Song Jia , Zhou Juan , Li Ran , Sun Ke , Zhang Jin , Wang Jiaying
Published: January 2024

Berberine, an active compound extracted from the Chinese herb, was reported to have an antibacterial effect and an anti‐inflammatory effect and promote osteogenic differentiation of human dental pulp stem cells. However, the underlying therapeutic mechanism of berberine in pulpitis is still unknown. Here, bioinformatics analysis was performed to investigate the potential mechanism of berberine against pulpitis. First, we identified the collective targets of berberine and pulpitis from several databases using a Venny online tool. The pattern of interaction between berberine and the targeted protein was visualized by molecular docking. Moreover, we performed GSEA, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses to obtain potential pathways. Cell experiments were performed to validate the bioinformatics analysis results. Prostaglandin‐endoperoxide synthase 2 (PTGS2) was identified as the crucial antipulpitis target of berberine via the CytoHubba plugin. Docking analysis indicated that berberine could fit in the binding pocket of the PTGS2 protein. Additionally, berberine exerted its therapeutic effects against pulpitis via multiple pathways. Overall, berberine possessed therapeutic effects against pulpitis through the inactivation of toll‐like receptor and NOD‐like receptor signaling pathways. The present research proposes a novel approach to explore the therapeutic mechanism of natural products.
The Y-Index of Some Complement Graph Structures and Their Applications of Nanotubes and Nanotorus
Authors: Alsharafi Mohammed , Alameri Abdu , Zeren Yusuf , Shubatah Mahioub , Alwardi Anwar
Published: January 2024

Topological descriptors play a significant role in chemical nanostructures. These topological measures have explicit chemical uses in chemistry, medicine, biology, and computer sciences. This study calculates the Y-index of some graphs and complements graph operations such as join, tensor and Cartesian and strong products, composition, disjunction, and symmetric difference between two simple graphs. Moreover, the Y-polynomial of titania nanotubes and the formulae for the Y-index, Y-polynomial, F-index, F-polynomial, and Y-coindex of the HAC5C7q,p and HAC5C6C7q,p nanotubes and their molecular complement graphs have been investigated.
Dry Sliding Wear Behavior of Copper Matrix Composites Enhanced with TiO2 and MoS2 Hybrids
Authors: Subbian V. , Sandeep H. , Jayasheel Kumar K. A. , Suthan R. , Vemula Ananda Mohan , Kalangi Chaithanya , Janaki Ramulu Perumalla , Tefera Dereje H. Georgis
Published: January 2024

The paper deals with the properties of copper-based composites. Copper is contributing to the field of automobiles and aerospace industries. The tribological properties of copper are not found to be satisfactory, which may be attributed to the support of producing copper matrix composites with extensive investigations into their properties. Coper-based hybrid composites were fabricated by reinforcing titanium dioxide (TiO2) and molybdenum disulphide (MoS2) to enhance the wear and mechanical properties of copper composites. Three specimens were prepared by powder metallurgy process with the designations of Cu + 5wt.%TiO2, Cu + 5wt.%TiO2 + 2wt.% MoS2, and Cu + 5wt.% TiO2 + 4wt.% MoS2. The metallurgical analysis was done on the specimens using X-ray diffraction (XRD) analysis which confirms the presence and distribution of Cu, TiO2, and MoS2 particles in the specimens. The wear rate was studied on the specimens concerning the sliding velocity, load, and MoS2 content. The statistical analysis and Taguchi analysis highlight the influencing parameters on the wear rate of the material. Linear regression equations were developed to predict the wear rate using DoE. Through this analysis, the sliding velocity of 3 m/s, a load of 30 N, and a 4% addition of MoS2 were identified as the optimum parameters for the minimal wear rate. The wear mechanism was analyzed using scanning electron microscopy techniques to reveal the adhesion, delamination, and oxidation.
A Blockchain‐Enabled Trading Framework for Distributed Photovoltaic Power Using Federated Learning
Authors: Piao Xuefeng , Ding Hao , Song Huihui , Liu Meng , Gao Song
Published: January 2024

As the integration of distributed energy into the power grid continues to rise, the significance of electricity transactions in promoting renewable energy consumption grows substantially. This necessitates the establishment of a robust electricity trading framework to facilitate reliable and trustworthy transactions for prosumers. This paper introduces an innovative blockchain‐based electricity trading framework. Within this framework, we present a decentralized collaborative model training approach aimed at predicting the power generation of distributed photovoltaic power stations. Simultaneously, we propose a graph‐based algorithm for efficiently matching producers and consumers. Our experiments, conducted on the Hyperledger Fabric blockchain platform using real‐world datasets, demonstrate enhanced prediction accuracy compared to existing models. The framework effectively handles transactions within one second, sustaining a sending rate of up to 200 transactions per second. The outcomes of this study not only surpass the performance of existing prediction models but also provide valuable insights for the development of trading frameworks in actual production environments. The proposed framework stands as a reference point for constructing reliable trading infrastructures, thereby contributing to the acceleration of green electricity trading.
Deep Neural Network-Based Cloth Collision Detection Algorithm
Authors: Jin Yanxia , Shi Zhiru , Yang Jing , Liu Yabian , Qiao Xingyu , Zhang Ling
Published: January 2024

The quality of collision detection algorithm directly affects the performance of the whole simulation system. To address the low efficiency and low accuracy in detecting the collisions of flexible cloths in virtual environments, this paper proposes an oriented bounding box (OBB) algorithm with a simplified model, tree structure for a root-node double bounding box, and continuous collision detection algorithm incorporating an OpenNN-based neural network optimization. First, for objects interacting with the cloths with more complex modeling, the model is simplified with a surface simplification algorithm based on the quadric error metrics, and the simplified model is used to construct an OBB. Second, a bounding box technique commonly used for collision detection is improved, and a root-node double bounding box algorithm is proposed to reduce the construction time for the bounding box. Finally, neural networks are used to optimize the continuous collision detection algorithm, as neural networks can efficiently process large amounts of data and remove disjoint collision pairs. An experiment shows that the construction of an OBB using the simplified model is almost identical to that of the original model, but the taken to construct the OBB is reduced by a factor of approximately 2.7. For the same cloth, it takes 5.51%–11.32% less time to run the root-node double bounding box algorithm than the traditional-hybrid bounding box algorithm. With an average removal rate nearly identical to that of the traditional filtering method, the elapsed time is reduced by 7%–11% by using the continuous collision detection algorithm based on an OpenNN neural network optimization. The simulation results are realistic and in line with the requirements for real-time cloth simulations.
Bilateral Subinternal Limiting Membrane Crystalline Deposits Secondary to Terson Syndrome
Authors: Ayalon Anfisa , Greenbaum Eran , Smolar Lily Okrent , Rubowitz Alexander
Published: January 2024

Background. We report the case of bilateral, subinternal limiting membrane crystalline deposits in a patient with Terson syndrome, describe the possible pathogenesis, and highlight management. Case Presentation. A 24-year-old male with a history of traumatic massive parenchymal and subdural frontal hemorrhage presented to our clinic seven months after a motor vehicle accident, prolonged hospitalization, and rehabilitation, complaining of decreased vision in both eyes. The Snellen visual acuity was 1/60 in the right eye, and 6/60 in the left eye. Fundus examination showed an organized white vitreous hemorrhage in both eyes with almost no view of the retina. The anterior segments were normal. He underwent a 25-gauge pars plana vitrectomy in both eyes. During the surgery, golden crescent-shaped sediment consisting of small crystals was observed under the internal limiting membrane in both eyes: anterior to the inferior temporal vascular arcade in the right eye and posterior to it in the left eye. Internal limiting membrane (ILM) peeling after staining with ILM-blue dye was performed in the left eye, where the finding involved the macula. One year after the surgery, visual acuity significantly improved to 6/8.5 on the right and 6/6 on the left. Epiretinal membrane formation was observed in the right eye, where ILM peeling was not performed. Conclusion. Subinternal limiting membrane crystalline deposit finding is a rare condition. Consider performing internal limiting membrane peeling and sediment removal in cases with macular involvement. In cases where crystals are concentrated outside of the macula, follow-up may be considered.
Alleviation of Rheumatoid Arthritis by Inducing IDO Expression with Trichinella spiralis Recombinant Protein 43
Authors: Ma Xiao , Liu Dongming , Yu Wenhao , Han Caixia
Published: January 2024

Rheumatoid arthritis (RA) represents the autoimmune disorder that shows aggressive arthritis as the main symptom. It is difficult to treat and can lead to joint deformation and function loss. At present, Trichinella spiralis (T. spiralis) antigen has attracted much attention because it plays a role in host immune regulatory mechanisms. Therefore, we selected T. spiralis recombinant protein 43 (Tsp43) to treat the bovine collagen type II (BCII)‐induced mice RA model and explored its therapeutic mechanisms. This work first verified that Tsp43 could promote the expression of indoleamine 2, 3‐dioxygenase (IDO) in dendritic cells (DCs) in vitro. Then, we randomized BALB/c mice (8 weeks old) into six groups, including control, phosphate buffer saline (PBS), BCII, BCII + heat inactivated Tsp43 (HiTsp43), BCII + Tsp43, and BCII + Tsp43 + 1‐methyl‐troptophan (1‐MT) groups. To determine the therapeutic effect of Tsp43 on the BCII‐induced mice RA model, relevant cytokines in each group and pathological changes in ankle joints were detected. To explore the mechanisms of Tsp43 on the BCII‐induced mice RA model, we checked the expression of IDO in each group, CD4+T cell proliferation, and apoptosis. Collectively, Tsp43 decreased tumor necrosis factor‐α (TNF‐α) and interleukin‐1β (IL‐1β) expression in BCII‐induced mice RA model and recovered the ankle injury to a certain extent. Tsp43 promoted high expression of IDO, caused expression of related apoptotic proteins in CD4+T cells, and caused apoptosis in CD4+T cells. In addition, Tsp43 reduced the proliferation of CD4+T cells. However, these effects can be inhibited by 1‐MT (IDO inhibitor). These results suggested that Tsp43 played an important role in the treatment of arthritis by inhibiting the proliferation of CD4+T cells and inducing CD4+T cells apoptosis through the high expression of IDO. The purpose of this experiment was to provide a new idea for the treatment of RA and lay a foundation for the development of parasite‐derived drugs for the treatment of RA.
An Optimum Design of a Subsonic Aircraft Wing due to the Aerodynamic Loading
Authors: Ismeal Ibtisam J. , Bakirci Mehmet , Jweeg Muhsin J.
Published: January 2024

Aircraft designers are mainly interested in finding the level of pressure, stresses, and deformations of the parts of the aircraft wing. In many aviation accidents, the failure of the wing is the main cause of disasters, as it is considered the main surface that generates the necessary lift for the aircraft in addition to its other functions in controlling the transverse stability. In this work, a numerical study was performed to obtain the optimum wing structural design parameters for high strength and minimum weight for the L-39 A/C wing. The wing was modeled as a honeycomb with different thicknesses using the software SOLIDWORKS 2020. The pressure distribution was predicted using the FLUENT 2022 R1 package. Having obtained the aerodynamic pressure, the deformations and stresses were obtained using the ANSYS program. The results were compared with other researchers using other models, such as using ribs and stringers in the interior structure of the wing. The current results were found to be reliable and acceptable from the design point of view of the high stiffness-to-weight ratio.
Risk of Gastric Adenocarcinoma in a Multiethnic Population Undergoing Routine Care: An Electronic Health Records Cohort Study
Authors: Huang Robert J. , Huang Edward S. , Mudiganti Satish , Chen Tony , Martinez Meghan C. , Ramrakhiani Sanjay , Han Summer S. , Hwang Joo Ha , Palaniappan Latha P. , Liang Su-Ying
Published: January 2024

Background:

Gastric adenocarcinoma (GAC) is often diagnosed at advanced stages and portends a poor prognosis. We hypothesized that electronic health records (EHR) could be leveraged to identify individuals at highest risk for GAC from the population seeking routine care.

Methods:

This was a retrospective cohort study, with endpoint of GAC incidence as ascertained through linkage to an institutional tumor registry. We utilized 2010 to 2020 data from the Palo Alto Medical Foundation, a large multispecialty practice serving Northern California. The analytic cohort comprised individuals ages 40–75 receiving regular ambulatory care. Variables collected included demographic, medical, pharmaceutical, social, and familial data. Electronic phenotyping was based on rule-based methods.

Results:

The cohort comprised 316,044 individuals and approximately 2 million person-years (p-y) of observation. 157 incident GACs occurred (incidence 7.9 per 100,000 p-y), of which 102 were non-cardia GACs (incidence 5.1 per 100,000 p-y). In multivariable analysis, male sex [HR: 2.2, 95% confidence interval (CI): 1.6–3.1], older age, Asian race (HR: 2.5, 95% CI: 1.7–3.7), Hispanic ethnicity (HR: 1.9, 95% CI: 1.1–3.3), atrophic gastritis (HR: 4.6, 95% CI: 2.2–9.3), and anemia (HR: 1.9, 95% CI: 1.3–2.6) were associated with GAC risk; use of NSAID was inversely associated (HR: 0.3, 95% CI: 0.2–0.5). Older age, Asian race, Hispanic ethnicity, atrophic gastritis, and anemia were associated with non-cardia GAC.

Conclusions:

Routine EHR data can stratify the general population for GAC risk.

Impact:

Such methods may help triage populations for targeted screening efforts, such as upper endoscopy.
Supplementary Table S1 from ERK1/2 Phosphorylation Predicts Survival in Recurrent Glioblastoma Following Intracerebral and Adjuvant PD-1/CTLA-4 Immunotherapy: A REMARK-guided Analysis
Authors: Arrieta Víctor A. , Duerinck Johnny , Burdett Kirsten B. , Habashy Karl J. , Geens Wietse , Gould Andrew , Schwarze Julia K. , Dmello Crismita , Kim Kwang-Soo , Saganty Ruth , Chen Li , Moscona Alberto , McCord Matthew , Lee-Chang Catalina , Horbinski Craig M. , Zhang Hui , Stupp Roger , Neyns Bart , Sonabend Adam M.
Published: January 2024

Supplementary Table 1. Clinical characteristics and p-ERK quantification of our GBM cohort treated with anti-PD-1 therapy
Supplementary Table S1 from SAR-096: Phase II Clinical Trial of Ribociclib in Combination with Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)
Authors: Movva Sujana , Matloob Sahar , Handorf Elizabeth A. , Choy Edwin , Merriam Priscilla , Flieder Douglas B. , Cai Kathy Q. , Zhou Yan , Tetzlaff Eric D. , Pagan Cheyenne , Barker Emma , Veggeberg Rosanna , Zumpano Delia , Rink Lori , von Mehren Margaret , George Suzanne
Published: January 2024

Supplementary Table S1: Representativeness of study participants
Supplementary Figure S2 from SAR-096: Phase II Clinical Trial of Ribociclib in Combination with Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)
Authors: Movva Sujana , Matloob Sahar , Handorf Elizabeth A. , Choy Edwin , Merriam Priscilla , Flieder Douglas B. , Cai Kathy Q. , Zhou Yan , Tetzlaff Eric D. , Pagan Cheyenne , Barker Emma , Veggeberg Rosanna , Zumpano Delia , Rink Lori , von Mehren Margaret , George Suzanne
Published: January 2024

Supplementary Figure S2:
Heatmap and hierarchical clustering of significantly expressed genes between responders and non-responders in archival LMS samples. Heatmap and hierarchical clustering is based on the expression levels of the 96 genes which are differentially expressed. The cutoffs used are false discovery rate (FDR) <5% and fold change >=2. Each column represents a sample and each row represents a gene. The log2 relative gene expression scale is depicted on the right.
Supplementary Table S3 from Pilot Study of High-Dose Pemetrexed in Patients with Progressive Chordoma
Authors: Kesari Santosh , Wagle Naveed , Carrillo Jose A. , Sharma Akanksha , Nguyen Minhdan , Truong Judy , Gill Jaya M. , Nersesian Raffi , Nomura Natsuko , Rahbarlayegh Elnaz , Barkhoudarian Garni , Sivakumar Walavan , Kelly Daniel F. , Krauss Howard , Bustos Matias A. , Hoon Dave S.B. , Anker Lars , Singh Arun S. , Sankhala Kamalesh K. , Juarez Tiffany M.
Published: January 2024

Table S3. Plasma and tissue samples from clinical trial participants used for miR WTA.
Supplementary Table S1 from Negative Hyperselection of Patients with HER2+ and RAS Wild-Type Metastatic Colorectal Cancer Receiving Dual HER2 Blockade: the PRESSING-HER2 Study
Authors: Randon Giovanni , Nakamura Yoshiaki , Yaeger Rona , Lonardi Sara , Cremolini Chiara , Elez Elena , Nichetti Federico , Ghelardi Filippo , Nasca Vincenzo , Bergamo Francesca , Conca Veronica , Ros Javier , Bando Hideaki , Maddalena Giulia , Oldani Simone , Prisciandaro Michele , Raimondi Alessandra , Schrock Alexa B. , Agnelli Luca , Walch Henry , Yoshino Takayuki , Pietrantonio Filippo
Published: January 2024

This table summarizes the different screening sources and the corresponding NGS assays.
Supplementary Table S1 from Pilot Study of High-Dose Pemetrexed in Patients with Progressive Chordoma
Authors: Kesari Santosh , Wagle Naveed , Carrillo Jose A. , Sharma Akanksha , Nguyen Minhdan , Truong Judy , Gill Jaya M. , Nersesian Raffi , Nomura Natsuko , Rahbarlayegh Elnaz , Barkhoudarian Garni , Sivakumar Walavan , Kelly Daniel F. , Krauss Howard , Bustos Matias A. , Hoon Dave S.B. , Anker Lars , Singh Arun S. , Sankhala Kamalesh K. , Juarez Tiffany M.
Published: January 2024

Table S1. Individual listing of clinical trial participants.
Supplementary Figure S5 from Pilot Study of High-Dose Pemetrexed in Patients with Progressive Chordoma
Authors: Kesari Santosh , Wagle Naveed , Carrillo Jose A. , Sharma Akanksha , Nguyen Minhdan , Truong Judy , Gill Jaya M. , Nersesian Raffi , Nomura Natsuko , Rahbarlayegh Elnaz , Barkhoudarian Garni , Sivakumar Walavan , Kelly Daniel F. , Krauss Howard , Bustos Matias A. , Hoon Dave S.B. , Anker Lars , Singh Arun S. , Sankhala Kamalesh K. , Juarez Tiffany M.
Published: January 2024

Supplementary Figure S5. Example of top 10 cfmiRs in plasma of clinical trial patients over the course of treatment. A-J: Graphs show changes in individual levels of cfmiRs in patients during course of treatment according to response. No statistically significant changes correlated to response in this small data set.
Supplementary Figure S1 from Negative Hyperselection of Patients with HER2+ and RAS Wild-Type Metastatic Colorectal Cancer Receiving Dual HER2 Blockade: the PRESSING-HER2 Study
Authors: Randon Giovanni , Nakamura Yoshiaki , Yaeger Rona , Lonardi Sara , Cremolini Chiara , Elez Elena , Nichetti Federico , Ghelardi Filippo , Nasca Vincenzo , Bergamo Francesca , Conca Veronica , Ros Javier , Bando Hideaki , Maddalena Giulia , Oldani Simone , Prisciandaro Michele , Raimondi Alessandra , Schrock Alexa B. , Agnelli Luca , Walch Henry , Yoshino Takayuki , Pietrantonio Filippo
Published: January 2024

Study flow-chart.
Supplementary Information on Materials and Methods 1 from Biomarkers of Pathologic Complete Response to Neoadjuvant Immunotherapy in Mismatch Repair–Deficient Colorectal Cancer
Authors: Li Jianxia , Hu Huabin , Qin Ge , Bai Fan , Wu Xianrui , Ke Haoxian , Zhang Jianwei , Xie Yuqian , Wu Zehua , Fu Yang , Zheng Hongbo , Gong Longlong , Xie Zhi , Deng Yanhong
Published: January 2024

Supplementary Information on Materials and Methods-Clean Version
Supplementary Table S4 from Detection of Recurrence through microRNA-371a-3p Serum Levels in a Follow-up of Stage I Testicular Germ Cell Tumors in the DRKS-00019223 Study
Authors: Belge Gazanfer , Dumlupinar Cansu , Nestler Tim , Klemke Markus , Törzsök Peter , Trenti Emanuela , Pichler Renate , Loidl Wolfgang , Che Yue , Hiester Andreas , Matthies Cord , Pichler Martin , Paffenholz Pia , Kluth Luis , Wenzel Mike , Sommer Jörg , Heinzelbecker Julia , Schriefer Philipp , Winter Alexander , Zengerling Friedemann , Kramer Mario Wolfgang , Lengert Marie , Frey Jana , Heidenreich Axel , Wülfing Christian , Radtke Arlo , Dieckmann Klaus-Peter
Published: January 2024

Supplementary Table S4. Time of recurrences detection (months) with standard diagnostics and with M371 test
Supplementary Table S4 from PDGFRβ Signaling Cooperates with β-Catenin to Modulate c-Abl and Biologic Behavior of Desmoid-Type Fibromatosis
Authors: Hu Jia , Hameed Meera R. , Agaram Narasimhan P. , Whiting Karissa A. , Qin Li-Xuan , Villano Anthony M. , O'Connor Rachael B. , Rozenberg Julian M. , Cohen Sonia , Prendergast Katherine , Kryeziu Sara , White Richard L. , Posner Mitchell C. , Socci Nicholas D. , Gounder Mrinal M. , Singer Samuel , Crago Aimee M.
Published: January 2024

CTNNB1 mutations detected in pre- and post-treatment biopsies from patients on ALLIANCE A091105.
Supplementary Table S3 from Detection of Recurrence through microRNA-371a-3p Serum Levels in a Follow-up of Stage I Testicular Germ Cell Tumors in the DRKS-00019223 Study
Authors: Belge Gazanfer , Dumlupinar Cansu , Nestler Tim , Klemke Markus , Törzsök Peter , Trenti Emanuela , Pichler Renate , Loidl Wolfgang , Che Yue , Hiester Andreas , Matthies Cord , Pichler Martin , Paffenholz Pia , Kluth Luis , Wenzel Mike , Sommer Jörg , Heinzelbecker Julia , Schriefer Philipp , Winter Alexander , Zengerling Friedemann , Kramer Mario Wolfgang , Lengert Marie , Frey Jana , Heidenreich Axel , Wülfing Christian , Radtke Arlo , Dieckmann Klaus-Peter
Published: January 2024

Supplementary Table S3. Clinical details and relative expression values of 261 CS1 follow-up patients