bluuebunny/crossref_metadata_2025 huggingface dataset:
Woolly beech aphid infestation reduces soil organic carbon availability and alters phyllosphere and rhizosphere bacterial microbiomes
Authors: Potthast Karin , Tischer Alexander , Herrmann Martina , Weinhold Alexander , Küsel Kirsten , van Dam Nicole M. , Michalzik Beate
Published: February 2022

Purpose

The woolly beech aphid thrives on European beech leaves, which has complex direct and indirect impacts on above- and belowground processes. A mechanistic understanding of insect-mediated changes in organic carbon (OC) availability for microbial life and its implications for element cycling is still lacking. This study aims at disentangling aphid-induced effects on phyllosphere and rhizosphere bacterial communities, as well as investigating feedbacks to OC transfer from the canopy to the mineral soil.

Methods

Following 2.5 months of infestation, we tracked the fate of OC (13CO2 pulse-labelling) in several compartments of beech sapling – soil mesocosms over 5 days. In ecosystem solutions, water extracts and soil/plant compartments we determined OC and N and solid δ13C. Bacterial community structure (16S rRNA gene targeted amplicon sequencing and quantitative PCR) and metabolite profiles (LC-qTOF-MS) were analysed.

Results

We found significantly higher aphid-mediated inputs of OC within throughfall. Honeydew-derived C on infested leaves was inconsequential for total phyllosphere bacterial abundances, but verifiably affected the community structure. In all soil compartments, cold-water extractable OC pools declined significantly by frequent inputs of readily available OC. This pattern might relate to reductions in rhizodepositions and altered microbial processing by accelerated soil C-mineralization. As a result, the abundance of metabolites changed significantly in different ecosystem solutions.

Conclusions

Our findings attest that insect infestations induce distinct direct and indirect effects on plant-insect-microbiome interactions leading to marked alterations in C dynamics. This integrated approach improves our understanding on microbial dynamics and biogeochemistry and evaluates the role of insects for ecosystem processes.
P2X7Rs: new therapeutic targets for osteoporosis
Authors: Huang Haoyun , He Yu-Mei , Lin Miao-Miao , Wang Yanchao , Zhang Xiaomei , Liang Li , He Xueling
Published: February 2022

Increasing evidence suggests that both the occurrence and progression of osteoporosis are associated with inflammation, especially in primary osteoporosis. The maintenance of skeletal homeostasis is dependent on the complex regulation of bone metabolism. Numerous evidence suggested that purinoceptor networks are essential for bone homeostasis. In this review, the relationship between inflammation and the development of osteoporosis and the role of P2X7 receptor (P2X7R) in regulating the dynamic regulation of bone reconstruction were covered. We also discussed how P2X7R regulates the balance between resorption and bone formation by osteoblasts and reviewed the relevance of P2X7R polymorphisms in skeletal physiology. Finally, we analyzed potential targets of P2X7R for osteoporosis.
MicroRNA: Crucial modulator in purinergic signalling involved diseases
Authors: Guo Jing , Yang Peng , Li Yi-Fan , Tang Jin-Fan , He Zhao-Xuan , Yu Shu-Guang , Yin Hai-Yan
Published: February 2022

Both microRNAs (miRNAs) and purinergic signalling are widely and respectively expressed in various tissues of different organisms and play vital roles in a variety of physiological and pathological processes. Here, we reviewed the current publications contributed to the relationship of miRNAs and purinergic signalling in cardiovascular diseases, gastrointestinal diseases, neurological diseases, and ophthalmic diseases. We tried to decode the miRNAs-purinergic signalling network of purinergic signalling involved diseases. The evidence indicated that more than 30 miRNAs (miR-22, miR-30, miR-146, miR-150, miR-155, miR-187, etc.) directly or indirectly modulate P1 receptors (A1, A2A, A2B, A3), P2 receptors (P2X1, P2X3, P2X4, P2X7, P2Y2, P2Y6, P2Y12), and ecto-enzymes (CD39, CD73, ADA2); P2X7 and CD73 could be modulated by multiple miRNAs (P2X7: miR-21, miR-22, miR-30, miR-135a, miR-150, miR-186, miR-187, miR-216b; CD73: miR-141, miR-101, miR-193b, miR-340, miR-187, miR-30, miR-422a); miR-187 would be the common miRNA to modulate P2X7 and CD73.
Adherence to Mediterranean diet in athletes: a narrative review
Authors: Calella Patrizia , Gallè Francesca , Di Onofrio Valeria , Cerullo Giuseppe , Liguori Giorgio , Valerio Giuliana
Published: February 2022

Athletes’ diet should be adequate both in quality and quantity, to avoid deficiencies and limit fatigue. In recent years, several nutritional recommendations have been published and a multitude of diets based on empirical approaches have been employed in the sport setting. In the last decades, the Mediterranean diet (MD) has been extensively studied for its beneficial effects on health but its adoption in athletes has never been critically analyzed. This review was aimed to assess the current literature about the athletes’ adherence to the MD pattern, also in comparison with the general population. The majority of the studies show that athletes reach a mean level of MD adherence, higher than that of the general population. However, the current evidence is still limited and based on studies using different methods. Further research is needed to better characterize this habit among athletes.
Synergetic adsorption–photocatalysis process for water treatment using TiO2 supported on waste stainless steel slag
Authors: Jimenez-Relinque Eva , Lee Siaw Foon , Plaza Lorenzo , Castellote Marta
Published: February 2022

This study presents an economical and efficient method to decolourise dye wastewater using industrial waste stainless steel slag (SSS). Titanium dioxide was immobilised on SSS by a precipitation–calcination method. Samples with different TiO2 loadings (prepared using either titanium isopropoxide precursor or commercial TiO2 nanoparticles) were used to decolourise an organic contaminant (methylene blue) under dark and UV conditions in aqueous solution, and their adsorption and photocatalytic performances were compared. Samples with 15 and 25 TiO2 wt% prepared by the precursor method had normalised photocatalytic efficiencies per gram close to that of bare TiO2; using an adsorption–photocatalysis process led to efficiencies 4.4 and 1.6 times higher than that of pure TiO2. The improvement in catalytic performance (greater for samples with less than 50% TiO2 content) may be due to better UV absorption ability (related to with the improvement of TiO2 particle dispersion) and the close TiO2 support interaction, which can eventually cause a photocatalysis-enhancing shift towards more negative oxidation potentials. The SSS also acted as an efficient adsorption trap for organic compounds. The pollutant was thus transferred to the TiO2 surface and photodegraded more rapidly and efficiently. The outstanding synergetic adsorption–photocatalysis capacities of TiO2 waste stainless steel slag composites for dye water treatment made the proposed conversion approach have great potential in practical applications.

Graphical abstract
Clinical Predictors of Engagement in Teleintegrated Care and Telereferral Care for Complex Psychiatric Disorders in Primary Care: a Randomized Trial
Authors: Severe Jennifer , Pfeiffer Paul N. , Palm-Cruz Katherine , Hoeft Theresa , Sripada Rebecca , Hawrilenko Matthew , Chen Shiyu , Fortney John
Published: February 2022

Background

Telepsychiatry Collaborative Care (TCC) and Telepsychiatry/Telepsychology Enhanced Referral (TER) expand the reach of specialty mental health services to underserved populations.

Objective

Assess clinical predictors of treatment engagement for complex psychiatric conditions in TCC—in which remote specialists consult with primary care teams via an onsite care manager who also provides brief psychotherapy—and TER, in which remote specialists provide direct telehealth treatment.

Design

A randomized pragmatic trial from twenty-four primary care clinics without onsite psychiatrists or psychologists.

Participants

A total of 1,004 adult patients screened positive for posttraumatic stress disorder (PTSD)and/or bipolar disorder were randomized to receive TCC or TER for 1 year.

Main Measures

Psychotherapy engagement was measured by the number of sessions completed, and pharmacotherapy engagement by the medication adherence item from the Schizophrenia Care and Assessment Program Health Questionnaire (SCAP-HQ).

Key Results

Engagement in TCC psychotherapy visits was greater compared to TER. There was no association between the PTSD symptom severity and treatment engagement. The internal state scale (ISS) activation subscale, an indicator of mania, was associated with reduced odds of initiating psychotherapy (odds ratio [OR] = 0.70; 95% CI, 0.59 to 0.84) but not the number of sessions attended once psychotherapy started. The Drug Abuse Screening Test-10(DAST-10) score was associated with receipt of fewer psychotherapy sessions (incidence ratio rate [IRR] = 0.88; 95% CI, 0.81 to 0.95). The number of physical health comorbidities was associated with greater engagement in psychotherapy (IRR = 1.11, 95% CI, 1.03 to 1.19) and pharmacotherapy (OR = 1.54; 95% CI, 1.27 to 1.87). None of the findings varied by intervention group.

Conclusions

Both teleintegrated and telereferral care offer an opportunity to treat patients with complex psychiatric conditions. While there was no difference in clinical characteristics predicting engagement, onsite care managers engaged patients in more psychotherapy sessions than remote therapists.

Trial Registration

ClinicalTrials.govIdentifier: NCT02738944
Advances and safe use of energy devices in lung cancer surgery
Authors: Homma Takahiro
Published: February 2022

Objectives

A clear understanding of energy devices would help achieve high effectiveness and safety and guide the selection of devices. The present review aimed to elucidate the efficacy and adverse events of energy devices in lung cancer to guide the selection of appropriate devices depending on the situation.

Methods

Four major databases were searched electronically for relevant articles published until 16 April 2021. The reference lists of the identified papers were examined. We excluded (1) irrelevant studies, (2) manuscripts published in languages other than English and Japanese, (3) duplicates, and (4) studies for which the full text was not available in the databases. The results and key information obtained were summarized by means of a narrative approach.

Results

A total of 78 papers were included in the review and these were categorized according to the main topic of investigation as follows: (1) electrosurgery-related injuries, (2) fundamentals of electrosurgery, (3) monopolar devices, (4) bipolar electrosurgical devices, (5) ultrasonic energy devices, (6) energy devices in lung cancer surgery, (7) operating room fire risks, and (8) basic principles of surgery.

Conclusions

Understanding energy devices could help us use them in a more effective and safer manner. Knowledge of their selection criteria (suitability), merits, risks, and safety precautions relevant to each process of lung cancer surgery could guide appropriate selection.
Informing the delivery of cancer survivorship care in rural primary care practice
Authors: Klemp J. R. , Knight C. J. , Lowry B. , Long T. , Bush C. , Alsman K. , Krebill H. , Peereboom D. , Overholser L. , Greiner K. A.
Published: February 2022

Purpose

The cancer survivor population is projected to increase to 22.2 million by 2030, requiring improved collaboration between oncology and primary care practices (PCP). PCPs may feel ill-equipped to provide cancer survivorship care to patients without input from cancer specialists. Compared with nonrural cancer survivors, rural cancer survivors report experiencing worse treatment-related symptoms. The goal of this study was to gain a better understanding of the perspectives of PCP teams towards survivorship care and to develop and test an interdisciplinary training program to improve cancer survivorship care in rural practice.

Methods

This study was conducted in two phases. First, focus groups were conducted with rural PCP teams to gather information regarding beliefs, practices, and barriers related to cancer survivorship care delivery. A thematic analysis was completed using an iterative process of reviewing transcripts. Results from phase 1 were used to inform the development of a pilot intervention tested within seven rural PCPs (phase 2). Pre- and post-intervention knowledge changes were compared, and post-session interviews assessed planned or sustained practice changes.

Results

Seven PCPs participated in focus groups (phase 1). Cross-cutting themes identified included (1) organizational barriers affecting the delivery of cancer survivorship care, (2) challenges of role delineation with specialists and patients, (3) difficulty accessing survivorship care and resources, and (4) providers’ lack of knowledge of cancer survivorship care. For phase 2, seven practices participated in four case-based educational sessions. Within and between practice changes were identified.

Conclusion

This project explored cancer survivorship perspectives among PCP teams. Lack of familiarity with evidence-based guidelines and the inability to identify cancer survivors was apparent during discussions and led to the implementation of the phase 2 intervention, iSurvive. As a result, PCPs either changed or planned changes to improve the identification and evidence-based care of cancer survivors.

Implications for Cancer Survivors

Address barriers to access cancer survivorship care in rural primary care practices.
Priority recommendations for the implementation of patient-reported outcomes in clinical cancer care: a Delphi study
Authors: Mazariego C. , Jefford M. , Chan R. J. , Roberts N. , Millar L. , Anazodo A. , Hayes S. , Brown B. , Saunders C. , Webber K. , Vardy J. , Girgis A. , Koczwara B. ,   on behalf of the COSA PRO Working Group
Published: February 2022

Purpose

The aim of this study was to develop priority recommendations for the service level implementation of patient-reported outcomes (PROs) into clinical cancer care.

Methods

Development of draft guidance statements was informed by a literature review, the Knowledge to Action (KTA) implementation framework, and discussion with PRO experts and cancer survivors. A two-round modified Delphi survey with key stakeholders including cancer survivors, clinical and research experts, and Information Technology specialists was undertaken. Round 1 rated the importance of the statements and round 2 ranked statements in order of priority.

Results

Round 1 was completed by 70 participants with round 2 completed by 45 participants. Forty-seven statements were rated in round 2. In round 1, the highest agreement items (>90% agreement) included those that focused on the formation of strong stakeholder partnerships, ensuring ongoing communication within these partnerships, and the use of PROs for improvement and guidance in clinical care. Items ranked as the highest priorities in round 2 included assessment of current staff capabilities and service requirements, mapping of workflows and processes to enable collection, and using collected PROs to guide improved health outcomes.

Conclusions

This stakeholder consultation process has identified key priorities in PRO implementation into clinical cancer care that include clinical relevance, stakeholder engagement, communication, and integration within the existing processes and capabilities.

Implication for Cancer Survivors

Routine adoption of PRO collection by clinical cancer services requires multiple implementation steps; of highest priority is strong engagement and communication with key stakeholders including cancer survivors.
MRI-Guided Cardiac Catheterization in Congenital Heart Disease: How to Get Started
Authors: Amin Elena K. , Campbell-Washburn Adrienne , Ratnayaka Kanishka
Published: February 2022

Purpose of Review

Cardiac magnetic resonance imaging provides radiation-free, 3-dimensional soft tissue visualization with adjunct hemodynamic data, making it a promising candidate for image-guided transcatheter interventions. This review focuses on the benefits and background of real-time magnetic resonance imaging (MRI)-guided cardiac catheterization, guidance on starting a clinical program, and recent research developments.

Recent Findings

Interventional cardiac magnetic resonance (iCMR) has an established track record with the first entirely MRI-guided cardiac catheterization for congenital heart disease reported nearly 20 years ago. Since then, many centers have embarked upon clinical iCMR programs primarily performing diagnostic MRI-guided cardiac catheterization. There have also been limited reports of successful real-time MRI-guided transcatheter interventions. Growing experience in performing cardiac catheterization in the magnetic resonance environment has facilitated practical workflows appropriate for efficiency-focused cardiac catheterization laboratories. Most exciting developments in imaging technology, MRI-compatible equipment and MRI-guided novel transcatheter interventions have been limited to preclinical research. Many of these research developments are ready for clinical translation.

With increasing iCMR clinical experience and translation of preclinical research innovations, the time to make the leap to radiation-free procedures is now.
Central Nervous System Impact of Perinatally Acquired HIV in Adolescents and Adults: an Update
Authors: Nichols Sharon L.
Published: February 2022

Purpose of Review

Perinatally acquired HIV infection (PHIV) can confer neurodevelopmental risk. As children with PHIV increasingly survive through adolescence and into adulthood, understanding its long-term central nervous system (CNS) impacts is critical for maximizing adult outcomes and quality of life.

Recent Findings

Recently published neurocognitive and neuroimaging findings show impacts on the CNS associated with early HIV disease progression that endure into adolescence and young adulthood. Although developmental trajectories in adolescence largely appear stable, further research on maturational processes is indicated.

Although early antiretroviral therapy in infancy appears to be protective, it is not universally available and current youth largely developed without its benefit. The neurocognitive effects of HIV and the multiple other risks to neurodevelopment experienced by youth with PHIV call for further longitudinal research and a multifaceted approach to prevention and intervention.
A Simple Whole-Plasmid PCR Method to Construct High-Diversity Synthetic Phage Display Libraries
Authors: Tsoumpeli Maria T. , Gray Alison , Parsons Aimee L. , Spiliotopoulos Anastasios , Owen Jonathan P. , Bishop Keith , Maddison Ben C. , Gough Kevin C.
Published: February 2022

Phage display technology utilises peptide and antibody libraries with very high diversities to select ligands with specific binding properties. The production of such libraries can be labour intensive and technically challenging and whilst there are commercial sources of libraries, the exploitation of the resulting binders is constrained by ownership of the libraries. Here, a peptide library of ~ 1 × 109 variants for display on gene VIII was produced alongside three VHH antibody libraries with similar diversity, where 12mer, 16mer or 21mer CDR3s were introduced into the highly stable cAbBCII10 scaffold displayed on gene III. The cloning strategy used a simple whole-plasmid PCR method and type IIS restriction enzyme assembly that facilitate the seamless insertion of diversity into any suitable phage coat protein or antibody scaffold. This method reproducibly produced 1 × 109 variants from just 10 transformations and the four libraries had relatively low bias with 82 to 86% of all sequences present as single copies. The functionality of both peptide and antibody libraries were demonstrated by selection of ligands with specific binding properties by biopanning. The peptide library was used to epitope map a monoclonal antibody. The VHH libraries were pooled and used to select an antibody to recombinant human collagen type 1.
Psoas muscle size, possible sarcopenia and frailty, and long-term survival in elderly patients after isolated surgical aortic valve replacement for aortic stenosis
Authors: Kondo Yasuo , Suzuki Tomoaki , Enomoto Masahide , Takashima Noriyuki , Kinoshita Takeshi
Published: February 2022

Purpose

This study investigated the use of psoas muscle area index (PAI) as an indicator of mortality risk in relation to survival in elderly patients after isolated surgical aortic valve replacement (SAVR) for aortic valve stenosis (AS).

Methods

Between January 2005 and March 2015, 140 patients with AS, aged ≥ 70 years, and with preoperative abdominal computed tomography scans, underwent elective, primary, isolated SAVR. PAI showed the ratio of the psoas muscle cross-sectional area at the fourth lumbar vertebral level to body surface area, and PAI less than the gender-specific lowest 20th percentile we called “low PAI” for the purposes of this study. Patients were classified as low PAI (n = 29) or normal PAI (n = 111).

Results

The mean age in the low-PAI group was significantly older than in the normal-PAI group (81.0 vs. 77.3 years; p = 0.001). The mean follow-up was 4.25 years. The low-PAI group had a lower survival rate than the normal-PAI group at 1 year (89.7 ± 5.7% vs. 96.3 ± 1.8%), at 3 years (71.6 ± 9.3% vs. 91.5 ± 2.7%), and overall (53.0 ± 13.4% vs. 76.0 ± 5.6%; p = 0.039). The prognostic factors of mortality included low PAI (hazard ratio 2.95; 95% confidence interval 1.084–8.079; p = 0.034).

Conclusions

PAI was associated with reduced overall survival after isolated SAVR in elderly people. PAI measurement may help to predict patient risks.
STAT1/IFIT2 signaling pathway is involved in PD-L1-mediated epithelial-to-mesenchymal transition in human esophageal cancer
Authors: Chen J. , Liu Y. , Zhu Y. , Chen Y. , Feng J. , Jiang T. , Zheng X. , Chen L. , Jiang J.
Published: February 2022

Background

We have previously reported significant change of epithelial to mesenchymal transition (EMT) phenotype of Eca-109 cells upon PD-L1 operation, and the cytoplasmic domain of PD-L1 played an essential role in promoting EMT of esophageal cancer cells. However, the underlying mechanism of how PD-L1 regulated EMT in esophageal cancer remained unclear.

Methods

The overexpression and knockdown expression models of PD-L1 and IFIT2 were established by using lenti-virus transfection and RNAi method. Western blotting, qRT-PCR, CCK8 assay, transwell assay and wound healing assay were chosen to investigate their impact on the cells. The expression levels of IFIT2 and EMT markers in esophageal cancer tissues were examined by immunohistochemical staining. The rescue experiments were further applied to investigate the role of STAT1/IFIT2 signal pathway in the PD-L1-mediated EMT. Luciferase reporter assays were performed to examine the IFIT2 promoter activities upon knockdown expression of PD-L1 to identify the putative targeted region of IFIT2 promoter.

Results

The STAT1/IFIT2 signal pathway was activated when PD-L1 was knockdown in human esophageal cancer cells. Decreased IFIT2 expression significantly increased the cellular abilities of viability, invasion and migration by using RNAi method in human esophageal cancer cells. Decreased IFIT2 expression in esophageal cancer tissues significantly correlated with EMT status, and could be used as an independent prognostic predictor for the patients. Rescue experiments in PD-L1 knockdown cells further confirmed that STAT1/IFIT2 pathway was involved in the PD-L1 mediated EMT of esophageal cancer cells. Moreover, the luciferase reporter assay also confirmed that in esophageal cancer cells, the promoter region of IFIT2 (-3K~-1K) remains more active in PD-L1 knockdown expression cells compared with controls.

Conclusion

Our present work reveals a novel mechanism of how PD-L1 regulates EMT of cancer cells, namely STAT1/IFIT2 signal pathway is required in PD-L1 mediated EMT in human esophageal cancer.
Numerical analysis of subgrain formation during metal cutting and rolling based on the crystal plasticity theory
Authors: Nagashima Fumihisa , Nakagawa Yuki , Yoshino Masahiko
Published: February 2022

The grain refinement technology is important in improving the metallic material properties without the requirement of additional alloy elements. Previously, we developed an efficient method for producing ultrafine-grained steel strips using a combination of cutting and heat treatment. However, the effect of cutting on recrystallization was not apparent. The objective of this study is to investigate the effects of metal cutting on static recrystallization and outline its advantages in grain refinement using numerical simulations based on the crystal plasticity theory. Simulation results show that shear deformation in metal cutting activates more slip systems than plane strain compression via rolling, even when considering the same equivalent plastic strain. The geometrically necessary dislocations are assumed to accumulate in the crystal because many slip systems are activated in shear deformation and improve grain refinement via static recrystallization in the subsequent heat treatment. This result indicates that the deformation type plays an important role in the recrystallization process. Thus, cutting is more efficient than rolling for the production of ultrafine-grained steel.
Design of robust control for uncertain fuzzy quadruple-tank systems with time-varying delays
Authors: Naami Ghali , Ouahi Mohamed , Rabhi Abdelhamid , Tadeo Fernando , Tuan Viet Long Bui
Published: February 2022

The robust$$H_\infty$$H∞observer-based control design is addressed here for non-linear Takagi-Sugeno (T-S) fuzzy systems with time-varying delays, subject to uncertainties and external disturbances. This is motivated by the quadruple-tank with time delay control problem. The observer design methodology is based on constructing an appropriate Lyapunov–Krasovskii functional (LKF) for an augmented system formed from the original and the delayed states. The bilinear terms are transferred to the linear matrix inequalities, thanks to a change of variables which can be solved in one step. Furthermore, by employing the$$\mathcal {L}_2$$L2performance index, the adverse effects of persistent bounded disturbances is largely avoided. The proposed method has the advantage of relating the controller and Lyapunov function to both the original and delayed states. Then, the controller and observer gains are obtained simultaneously by solving these inequalities with off-the-shelf software (Yalmip/MATLAB toolbox). Finally, an application to a simulated quadruple-tank system with time delay is carried out to demonstrate the benefits of the proposed technique, showing a compromise between controller simplicity and robustness that outperforms previous approaches.
Meta-analysis of Supply Chain Disruption Research
Authors: Novoszel Lydia , Wakolbinger Tina
Published: February 2022

The purpose of this chapter is to provide insights into literature on supply chain disruption research with a specific focus on future research opportunities. A structured meta-literature review approach covering 93 literature reviews was chosen. Quantitative and qualitative content analysis and bibliographic network analysis are applied to highlight trends and research gaps. The meta-analysis shows the current and past academic discourse on supply chain disruptions. Furthermore, this research establishes a research framework and highlights future research opportunities. The research points to research topics that should be addressed in the future. The paper provides a holistic understanding of literature on supply chain disruptions in the commercial and humanitarian context.
The role of religion in female labor supply: evidence from two Muslim denominations
Authors: Akyol Pelin , Ökten Çağla
Published: February 2022

This paper investigates the association between religion and female labor market outcomes using new micro-level data on two distinct Muslim denominations in Turkey: Sunni and Alevi Muslims. We find a positive and significant association between being an Alevi Muslim and female labor force participation and employment, whereas there are no significant differences in male labor market outcomes between the two denominations. We provide evidence that Alevi Muslims have more gender-equal views regarding the role of women in the labor market and consider themselves as more modern. Both Sunnis and Alevis consider themselves as believers in religion (Islam). However, Sunnis are more likely to abide by the rules of religion. We argue that differences in views on gender roles and self-identity regarding modernity between the two denominations drive the results on female labor market outcomes.
They, the people. Italian Fascism and the ambivalences of corporative populism
Authors: Cerasi Laura
Published: February 2022

This paper argues that, in terms of their view of the ‘people’, leaderistic plebiscitarism and corporative organicism are two sides of the same coin, which resulted in aspirational fascist totalitarian democracy. The binary – and intrinsically ambiguous – view of the ‘people’ is examined first in the passive and indeterminate qualities attributed to the Italian population, then in the institutional device designed to lead it. The resulting twofold paradigm of corporative populism is reviewed with reference to the model put together and popularised by Giuseppe Bottai, which is presented in three different forms.
The Assault on Civil Society: Explaining State Crackdown on NGOs
Authors: Chaudhry Suparna
Published: February 2022

Nongovernmental organizations are central to contemporary global governance, and their numbers and influence have grown dramatically since the middle of the twentieth century. However, in the last three decades more than 130 states have repressed these groups, suggesting that a broad range of states perceive them as costly. When they choose to repress NGOs, under what conditions do states use violent strategies versus administrative means? The choice depends on two main factors: the nature of the threat posed by these groups, and the consequences of cracking down on them. Violent crackdown is useful in the face of immediate domestic threats, such as protests. However, violence may increase the state's criminal liability, reduce its legitimacy, violate human rights treaties, and further intensify mobilization against the regime. Therefore, states are more likely to use administrative crackdown, especially in dealing with long-term threats, such as when NGOs influence electoral politics. I test this theory using an original data set of administrative crackdowns on NGOs, as well as violent crackdown on NGO activists, across all countries from 1990 to 2013. To shed light on the strategic decision between violent or administrative crackdown, and how states may perceive threats from domestic and international NGOs differently, I provide a case study from India. I conclude by discussing the implications of this crackdown for the use of civil society actors by the international community, as well as donors and citizens in the global South.
Three new species of Duplicibothrium (Cestoda: ‘Tetraphyllidea’) from cownose rays in Senegal with a phylogenetic analysis of the genus
Authors: Stephan Douglas , Caira Janine N.
Published: February 2022

Three new species of ‘tetraphyllideans’ in the family Serendipeidae are described from cownose rays off Senegal. Duplicibothrium jeannettae n. sp. and Duplicibothrium collosum n. sp. parasitize both Rhinoptera marginata and Rhinoptera peli. Duplicibothrium jillae n. sp. parasitizes R. marginata. Duplicibothrium jeannettae n. sp. and D. jillae n. sp. differ from one another and their described congeners in size, number of proglottids, and locular configuration. The generic assignment of D. collosum n. sp. was initially unclear because its scolex more closely resembles that of Serendip than Duplicibothrium. To help inform generic placement, sequence data were generated for the 28S rDNA gene (D1–D3 region) for the three new species as well as for Duplicibothrium minutum and Duplicibothrium n. sp. 2 from Rhinoptera bonasus off North Carolina, Duplicibothrium n. sp. 3 from Rhinoptera brasiliensis off Belize, Duplicibothrium n. sp. 4 and Duplicibothrium n. sp. 5 from Rhinoptera jayakari off Mozambique, and Duplicibothrium n. sp. 6 from Rhinoptera neglecta off Australia. Comparable data were obtained from GenBank for adults and larvae of Duplicibothrium collected from the Gulf of Mexico. The tree resulting from a maximum likelihood analysis (MLA) placed D. collosum n. sp. robustly within Duplicibothrium; the generic diagnosis is emended accordingly. This raises a question regarding the independence, and thus also validity, of the three genera of the Serendipeidae – a question that must await a molecular analysis that includes Serendip and Glyphobothrium. These results extend the hosts of Duplicibothrium to include R. brasiliensis, R. jayakari, R. marginata, R. neglecta and R. peli, and the distribution to include the western Pacific Ocean, eastern Atlantic Ocean, and western Indian Ocean (Zoobank Registration: 97BB5020-BFFF-4FEA-AE07-B4711D1110FC).
Effects of primary Sjögren's syndrome on hearing and vestibular systems
Authors: Ulusoy B , Limon M , Yılmaz S , Çolpan B , Aygün A A , Körez M K , Erdur Ö
Published: February 2022

Objective

This study aimed to evaluate primary Sjögren's syndrome patients in terms of hearing and vestibular functions.

Methods

The patient group consisted of 35 individuals diagnosed with primary Sjögren's syndrome and a control group of 35 healthy individuals similar in terms of age and gender.

Results

The rate of hearing loss in the patient group was significantly higher than in the control group (p = 0.021). The N1 latency value for the ocular vestibular-evoked myogenic potentials test was significantly longer in the patient group than in the control group (p = 0.037). Additionally, the posterior semicircular canal and lateral semicircular canal vestibulo-ocular reflex gain values were significantly lower than in the control group (p = 0.022 and p < 0.001, respectively).

Conclusion

These results indicate subclinical vestibular involvement and hearing loss in primary Sjögren's syndrome patients. Vestibular-evoked myogenic potentials and video head impulse tests can be used to detect vestibular involvement in primary Sjögren's syndrome patients.
Good, Actually: Aristotelian Metaphysics and the ‘Guise of the Good’
Authors: Willows Adam M.
Published: February 2022

In this paper I argue that both defence and criticism of the claim that humans act ‘under the guise of the good’ neglects the metaphysical roots of the theory. I begin with an overview of the theory and its modern commentators, with critics noting the apparent possibility of acting against the good, and supporters claiming that such actions are instances of error.

These debates reduce the ‘guise of the good’ to a claim about intention and moral action, and in so doing have become divorced from the theory's roots in classical and medieval philosophy. Aristotle and Aquinas’ ‘guise of the good’ is primarily a metaphysical claim resting on the equivalence between actuality and goodness, from which conclusions about moral action are derived. I show the reasoning behind their theory and how it forms the basis for the claims about intention and action at the centre of the modern debate. Finally, I argue that the absence of its original foundation is apparent in recent attacks on the ‘guise of the good’. It is unsurprising that modern action theory and ethics have not always been able to comfortably accommodate the ‘guise of the good’; they are only telling half of the story.
The Literary Artistry of Terentianus Maurus
Authors: Keeline Tom
Published: February 2022

Terentianus Maurus, a North African writing probably in the third centurya.d., bequeathed to posterity a preface and three polymetric poems:De litteris, De syllabisandDe metris. The poems’ titles reflect their content, the first two covering the pronunciation of letters and syllables and the third discussing the details of a bewildering array of metres. Unpromising subject matter for poetry? On the contrary. Terentianus Maurus uses this raw material to display his extraordinary poetic skill, while also conveying useful technical information. This paper first examines the programmatic preface to his poems, which is studded with intertextual gems and shines with every kind of literary polish. It then turns to look at passages from the rest of Terentianus’ poetry to see how he puts the ideals of his preface into poetic practice. The paper aims to show that Terentianus Maurus is not, or not just, a grammarian, but rather a consummate literary artist in the tradition of learned didactic verse.
Vocalization and physiological hyperarousal in infant–caregiver dyads where the caregiver has elevated anxiety
Authors: Smith Celia G. , Jones Emily J. H. , Charman Tony , Clackson Kaili , Mirza Farhan U. , Wass Sam V.
Published: February 2022

Co-regulation of physiological arousal within the caregiver–child dyad precedes later self-regulation within the individual. Despite the importance of unimpaired self-regulatory development for later adjustment outcomes, little is understood about how early co-regulatory processes can become dysregulated during early life. Aspects of caregiver behavior, such as patterns of anxious speech, may be one factor influencing infant arousal dysregulation. To address this, we made day-long, naturalistic biobehavioral recordings in home settings in caregiver–infant dyads using wearable autonomic devices and miniature microphones. We examined the association between arousal, vocalization intensity, and caregiver anxiety. We found that moments of high physiological arousal in infants were more likely to be accompanied by high caregiver arousal when caregivers had high self-reported trait anxiety. Anxious caregivers were also more likely to vocalize intensely at states of high arousal and produce intense vocalizations that occurred in clusters. High-intensity vocalizations were associated with more sustained increases in autonomic arousal for both anxious caregivers and their infants. Findings indicate that caregiver vocal behavior differs in anxious parents, cooccurs with dyadic arousal dysregulation, and could contribute to physiological arousal transmission. Implications for caregiver vocalization as an intervention target are discussed.
Width of the temperature range for seed germination of herbaceous plant species in temperate eastern North America: life cycles, seasons and temperature variation and implication for climate warming
Authors: Baskin Carol C. , Baskin Jerry M. , Hu Xiao Wen , Zhang Chun Hui
Published: February 2022

To persist (without immigration) in habitats with unpredictable environmental conditions, annuals must produce seeds each year or have a seed bank. Thus, we predicted that compared to perennials, annuals have a wider germination temperature range (GTR, the difference in temperature between the week with the highest and the week with the lowest germination during the natural germination season). We determined the GTR via germination phenology data for 350 herbaceous species in 59 families from the eastern USA: summer annuals (SA), 63; winter annuals (WA), 83; monocarpic perennials (MP), 28; and polycarpic perennials (PP), 176. There was no significant phylogenetic signal for the GTR. The width of the GTR during the first spring germination season was 9.6, 8.7 and 8.8°C for MP, PP and SA, respectively, and during the first autumn germination season 12.8, 11.8 and 12.4°C for MP, PP and WA, respectively. Annuals did not have a wider GTR than perennials in either the spring or the autumn germination season. Our data suggest that selection for early germination in either spring or autumn has resulted in only small differences in the GTR. We predict that global warming will have little or no effect on reshaping the germination phenology of herbaceous species of temperate eastern North America.
Constrictive pericarditis: rare but reversible cause of protein losing enteropathy
Authors: Shah Nishant C. , Kiraly Laszlo , El Badaoui Hazem
Published: February 2022

Constrictive pericarditis is uncommon in children. It results from scarring and consequent loss of the normal elasticity of the pericardial sac and is most commonly seen as a late sequelae of idiopathic or viral pericarditis. Here, we report a case of protein losing enteropathy as a complication of constrictive pericarditis in a 2-year-old child. Pericardial thickening was demonstrated by cardiac MRI and subsequent pericardiectomy led to remarkable improvement and resolution of protein losing enteropathy.
Christian Formation and Education in Episcopal Boarding Schools: Historical Origins, Contemporary Context, and a Proposal for Reform
Authors: McDonald Emma
Published: February 2022

This article will consider James K.A. Smith’s proposal for Christian educational reform by examining the historical animating principles and the contemporary embodied practices of Episcopal boarding schools in the United States. Drawing on historical accounts of the early years of Episcopal boarding schools, this paper will surface resonances between Smith’s vision for Christian education and the hopes of the first rectors of Episcopal boarding schools. Moving from the founding of these schools to their contemporary configurations, this paper will draw on ethnographic accounts of Episcopal boarding schools to complicate Smith’s vision of the formative Christian school. Ethnographic accounts of Episcopal schools offer further support for Smith’s cultural liturgies paradigm; at the same time, the concrete realities of Episcopal boarding schools will call into question Smith’s convictions regarding the potential for Christian schools to operate counter-liturgically. A consideration of the Episcopal Church’s ecclesial mission will demonstrate how it departs from Smith’s post-liberal ecclesiology to suggest realistic ways forward in the negotiation of Christian identity and practice in the context of Episcopal boarding schools.
CME: Light Therapy: Why, What, for Whom, How, and When (And a Postscript about Darkness)
Authors: Wirz-Justice Anna , Terman Michael
Published: February 2022

Abstract. Light therapy has become established as an evidence-based treatment for Seasonal Affective Disorder. Light impacts the timing and stability of circadian rhythms as expressed in sleep, mood, alertness, and cognition. Forty years of clinical trials and open treatment have led to guidelines for patient selection, using light alone or in combination with antidepressants (or lithium for bipolar depression). Mood and sleep disturbances can also respond to adjunct light therapy in a broader set of psychiatric, neurologic and medical illnesses. We specify criteria for choice of treatment devices: optimum dose (10,000 lux), spectrum (white light), exposure duration (30–60 minutes) and timing (early morning). Protocol adjustment requires continual monitoring with attention to rate of improvement and management of potential side effects.
Agent‐Based Model to Manage Household Water Use Through Social‐Environmental Strategies of Encouragement and Peer Pressure
Authors: James R. , Rosenberg D. E.
Published: February 2022

Water conservation has long been an effective component of sustainable water management. However, inelastic price responses, demand hardening, and poor public awareness reduce the effectiveness of strategies. Here, we identify and quantify the effects of psychological and social factors such as attitudes, peer support, opportunities to conserve, and encouragement on household water use. We link household survey, municipal billing, aerial imagery, weather, and appliance flow and duration data. We use the data to develop, populate, and partially validate an agent‐based model for 270 households in Logan, Utah. Simulated indoor water use matched observed use better than outdoor use and improved over prior studies that only conceptually validated model results. Households with stronger conservation attitudes, peer support, and more opportunities saved the most water. Peer pressure saved more water than water manager encouragement because small, diverse social networks could better regulate the behavior of outlier households within the network. Combining peer pressure and encouragement saved the most water. Results suggest managers should provide platforms for households to share their water use stories and information with each other. Managers should target conservation actions to the small fraction of households who use the most water and have large potential to save water. Mangers can use the psychological and social factors to increase household adoption of water conservation actions.
Large Soil Carbon Storage in Terrestrial Ecosystems of Canada
Authors: Sothe Camile , Gonsamo Alemu , Arabian Joyce , Kurz Werner A. , Finkelstein Sarah A. , Snider James
Published: February 2022

Terrestrial ecosystems of Canada store a large amount of organic carbon (C) in soils, peats and plant materials, yet little is known about the C stock size and distributions, both spatially and in various C pools. As temperature rises, C is becoming available for disturbance, decomposition and eventual release into the atmosphere, which makes the quantification of C stocks in terrestrial ecosystems of Canada of high interest for the assessment of climate change impacts and conservation efforts. We used a large number of field measurements, multisource satellite, climate and topographic data and a machine learning algorithm to produce the first wall‐to‐wall estimates of C stocks and uncertainties in plants and soils of Canada at 250 m spatial resolution. Our findings show that above and belowground live biomass and detritus store a total of 21.1 Pg of carbon (Pg C). Whereas the Canadian soils store 306 (±147, 90% confidence interval) Pg organic C in the top 1 m, 98 Pg C of which are stored in peatlands, confirming that the soil organic C dominates terrestrial carbon stocks in Canada. We also find previously under‐reported large soil organic C stocks in forested peatlands on the boreal shields of Canada. Given that Canada is warming twice the global average rate and Canadian soils store approximately 20.4% of world soil C stocks in top 1 m, initiatives to understand their vulnerabilities to climate change and disturbance are indispensable not only for Canada but also for the global C cycle.
Solar Wind Velocities at Comets C/2011 L4 Pan‐STARRS and C/2013 R1 Lovejoy Derived Using a New Image Analysis Technique
Authors: Ramanjooloo Yudish , Jones Geraint H.
Published: February 2022

The ion tails of bright comets have long been considered as a natural tracers of the solar wind (SW) near these objects. Studies of comets and their ion tails allow inexpensive monitoring of key SW structures in the inner heliosphere, much of which is otherwise only accessible by in situ SW spacecraft measurements. Here, we present a novel technique to mine the rich archive of amateur, professional and spacecraft observations of cometary ion tails. To demonstrate this, we focus on Near‐Sun comet C/2011 L4 (Pan‐STARRS) during Carrington Rotations (CR) 2134 and 2135 and comet C/2013 R1 (Lovejoy) during CR 2118. We outline the technique’s shortcomings, including its geometric limitations, and present a catalog of radial SW velocities derived in the near‐comet environment and information on the heliospheric conditions inferred from the measured SW. Complementary measurements, derived from folding ion rays and a velocity profile map built from consecutive images, are provided as an alternative means of quantifying the SW ‐cometary ionosphere interaction. We find that comets are generally good indicators of SW structure, but the quality of the results is strongly dependent on the observing geometry.