bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the Structural Diversity of Novel 3-Substituted Coumarins as Potent Inhibitors of Tumor-Associated Carbonic Anhydrases: Expanding the Pharmacological Space for Anticancer Drug Discovery
Authors: Matar Islam , Al-Hussain Sami , Muhammad Zeinab , Zaki Magdi , Gomha Sobhi , El-khouly Ahmed
Published: July 2023

Innovations in cancer chemotherapy continue to occupy the priority list of demands to ensure our health security. The vast chemical space provides a plethora of anticancer discovery opportunities, however, limited by the boundaries of synthetic feasibility. This study aims at expanding the established pharmacological space of tumor-associated carbonic anhydrases by exploring the synthetically feasible chemical space of 3-substituted coumarins. A series of 52 novel 3-substituted coumarins were randomly sketched by our team of synthetic chemists with priority given to synthetic feasibility. The pharmacological potentials of the novel coumarin series were computationally estimated using a machine-learning approach exploiting both chemical and statistical inference. 17 members of the novel series were predicted to possess cytotoxic activity against HeLa cells by interfering with the tumor-associated carbonic anhydrases IX and XII. Those 17 compounds were synthesized and biologically tested against HeLa cells, subsequently; the 3 most potent compounds were assayed against carbonic anhydrases I, II, IX, and XII employing Acetazolamide as a reference. The molecular binding mechanism of those 3 chosen compounds with the four enzyme isoforms was studied using molecular docking simulation. Most of the compounds exhibited competent inhibitory activity against HeLa cells. The carbonic anhydrase inhibition results unveiled the powerful but non-selective nature of those suicide inhibitors. In conclusion, Novel 3-substituted coumarins have been dispatched to join the pharmacological space of tumor-associated carbonic anhydrases’ suicide inhibitors.
Exploring reproducible non-aqueous scanning droplet cell electrochemistry in model battery chemistries
Authors: Sanin Alexey , Stein Helge Sören
Published: July 2023

The discovery and optimization of new materials for energy storage is essential for a sustainable future. High-throughput experimentation (HTE) using a scanning droplet cell (SDC) is suitable for the rapid screening of prospective material candidates and effective variation of investigated parameters over a millimeter-scale area. Herein, we explore the transition and challenges for SDC electrochemistry from aqueous towards aprotic electrolytes and address pitfalls related to reproducibility in such high-throughput systems. Specifically, we explore whether comparable reproducibilities are achievable on the millimeter half-cell level than for full cells. To study reproducibility in half-cells as a first screening step this study explores the selection of appropriate cell components, such as reference electrodes (REs) and the use of masking techniques for working electrodes (WEs) to achieve consistent wetted areas. Experimental results on a Li-Au model anode system show that SDC, coupled with a masking approach and subsequent optical microscopy, can mitigate issues related to electrolyte leakage and yields good reproducibility. The proposed methodologies and insights contribute to the advancement of high-throughput battery research, enabling the discovery and optimization of future battery materials with improved efficiency and efficacy.
Voice onset time of plosive consonants in initial position in badidni dialect
Authors: Kamel Warhel , Salih Salwa
Published: July 2023

Phoneticians have presented several ways and theories for knowing the features and characteristics of plosive consonants. Acoustic ways are ones that languages’ plosive consonants are determined by them. In the last 60 years VOT was widely used as an acoustic parameter by phoneticians for comparing voicing contrast and determining the categories and features of plosive consonants as an acceptable way. Until now it’s not known that plosive consonants are determined in badini dialect according to the VOT parameter. This study is an attempt to what extent we can benefit from the mentioned parameter for specifying voicing contrast distinction, voicing categories and their properties and features. For this purpose the two plosive consonants /b, p/ are used as a stimulus of this investigation in the initial 6 monosyllabic words in the environment of the two vowels /ɑ æ,/. The collected data are taken from (20) badini dialect speakers. It’s assumed that voicing contrast, VOT values and the categories of plosive (voiced and voiceless) consonants are different in baddini dialect. Depending on procedures and statistical analysis tests it concludes that; VOT is formed in three ways and three separate values. This study consists of five sections; the first section is the introduction, the second one is theoretical framework, in the third section the procedures of doing this study are shown, statistical results and discussing them are mentioned in the fourth section and the conclusions of the study are shown in the fifth section.
THE IDEAL IMAGE OF A MAN FROM A MILITARY-ARISTOCRATIC ENVIRONMENT IN THE REFLECTION OF THE RUS FRONTIER PRINCIPALITIES’ CHRONICLES IN XI – XIV CENTURIES: ORIGINS, PARALLELS, ANALOGIES
Authors: Новиков А.С.
Published: July 2023

В статье поднимается проблема происхождения и развития предлагаемого русскими летописями и представленного преимущественно князьями образа мужчины из военно-аристократической среды. Военная аристократия в Средние века является своего рода отражением эпохи, поэтому анализ образа русского князя позволит рассмотреть некоторые внутренние особенности мировоззрения средневекового мужчины. Констатируется, что на исследуемом этапе своего развития мужской образ является универсальным, выходя за географические границы Руси и находя аналогии в иностранных свидетельствах, в частности, на территории Скандинавии и на Востоке, и демонстрирует живущего войной и тесно связанного с дружиной правителя-воина.

The article raises the problem of the origin and development of the image of the ideal man from the military-aristocratic environment, proposed by the Rus’ chronicles and presented mainly by the dukes. The military aristocracy in the Middle Ages is a kind of mirror of the era, so the analysis of the ideal image of the Rus’ duke will allow us to consider some of the internal features of the worldview of a medieval personality. It is stated that at the researched stage of its development, the ideal male image is universal, going beyond the geographical boundaries of Rus’ and finding analogies in foreign testimonies, in particular, in Scandinavia and the East, and demonstrates a leader-warrior living in war and closely connected with the retinue.
PHÁT HIỆN MỘT SỐ THUỐC HẠ GLUCOSE MÁU TRỘN LẪN TRONG CHẾ PHẨM DƯỢC LIỆU BẰNG PHƯƠNG PHÁP SẮC KÝ LỎNG HIỆU NĂNG CAO (HPLC)
Authors: Lê Thị Bảo Trâm , Tạ Nguyễn Khánh Hà , Hoàng Thị Minh Nguyệt , Phạm Thị Thanh Hà , Nguyễn Thị Kiều Anh , Nguyễn Hải Phong , Huỳnh Văn Chung , Đào Thị Cẩm Minh
Published: July 2023

Thông tư số 10/2021/TT-BYT quy định một số thuốc hạ glucose máu, như metformin hydroclorid, là các chất cấm trộn lẫn trong chế phẩm có nguồn gốc từ dược liệu. Do đó, mục tiêu nghiên cứu này là xây dựng quy trình phát hiện năm loại hoạt chất hạ glucose máu, gồm metformin hydroclorid, glibenclamid, gliclazid, glimepirid và glipizid, trộn lẫn trong chế phẩm có nguồn gốc dược liệu bằng phương pháp sắc ký lỏng hiệu năng cao (HPLC). Chúng tôi đã xây dựng được chương trình sắc ký gồm hệ pha động methanol:đệm phosphat pH 3 với tỷ lệ 30/70 (v/v), cột sắc ký C18 (250 × 4,6 mm, 5 μm), và thời gian phân tích 25 phút. Phương pháp thẩm định có tính đặc hiệu cao, độ đúng, độ lặp lại và độ tái lặp cao, đạt yêu cầu theo AOAC. Chúng tôi đã phát hiện bảy mẫu chế phẩm dược liệu dương tính trong đó sáu mẫu dương tính với glibenclamid và một mẫu dương tính đồng thời với metformin và glibenclamid.
KỸ THUẬT CHUẨN BỊ MẪU QuEChERS KẾT HỢP VỚI GC-MS ĐỂ PHÂN TÍCH ĐỒNG THỜI HOÁ CHẤT BẢO VỆ THỰC VẬT TRONG RAU, CỦ, QUẢ
Authors: Huỳnh Thị Túy Ngọc , Châu Nguyễn Đăng Giáng
Published: July 2023

Tồn dư hoá chất bảo vệ thực vật trong nông sản là thước đo quan trọng để đánh giá mức độ an toàn thực phẩm. Nghiên cứu này phát triển và thẩm định một phương pháp phân tích có hiệu quả rất tốt để xác định đồng thời dư lượng của chín loại hoá chất bảo vệ thực vật thế hệ mới trong rau, củ, quả. Trong phương pháp này, chúng tôi áp dụng kỹ thuật chuẩn bị mẫu QuEChERS, sử dụng MgSO4 và natriacetate trihydrate cho bước làm sạch ban đầu; sau đó, chiết phân tán bằng chất hấp phụ PSA và GCB để loại bỏ toàn bộ tạp chất có trong nền mẫu và kết hợp với GC-MS để định tính và định lượng. Phương pháp đánh giá có giới hạn phát hiện thấp đối với các chất phân tích (3–8 µg·kg–1), độ thu hồi tốt (70–120%), độ lặp lại tốt và độ tuyến tính cao. Khi áp dụng thực tế để phân tích các mẫu rau, củ, quả thu thập tại các chợ trên địa bàn tỉnh Thừa Thiên Huế, chúng tôi đã phát hiện thấy tồn dư của một số HCBVTV ở mức cao.
Analysis of Approaches to Determining the Atmosphere Pollution Level of Settlements
Authors:   Irkutsk State University, Akhtimankina A. V. , Eroshkin V. M. ,   Irkutsk State University
Published: July 2023

The aim of the work is to analyze the methodology for calculating indices are used both in the Russian Federation and in a number of foreign countries, that allow us to draw a conclusion about the level of atmospheric pollution. The article considers approaches to the calculation of such indices as IZA, KIZA (Russia), AQI (USA, Australia), DAQI (Great Britain), CAQI, YACAQI (European Union), AQHI (Canada, Hong Kong), PSI (Singapore). The main calculation formulas of the indices, the parameters on the basis of which they are calculated and how the results can be interpreted are described. The conclusion about the applicability of these methods on the territory of Russia is made. The calculation part was made on the basis of data on the concentrations of pollutants obtained at automatic atmospheric air monitoring stations in Irkutsk for 2019. In addition, the absolute and relative frequency of occurrence of various index values was calculated. It was found that despite the apparent similarity of the results, the analysis should be carried out at the level of sub-indices or pollution indices for each individual substance. In addition, the calculation of the absolute and relative frequencies of the occurrence of indices corresponding to different levels of pollution showed that averaging the results hides the occurrence of dangerous levels of pollution that may be critical for sensitive population groups (people with chronic diseases, children, the elderly).
Asian Century Dream and Power Politics: A Study of India China Rivalry of 21st Century
Authors: N.P. Shahid
Published: July 2023

The concept of ‘Asian Century’ has yet to be widely embraced among the scholars and practitioners of International Relations. If the Asian Century has indeed become ‘a defining feature of the 21st century’, it matters to discuss the rivalry between two super powers of Asia and its relationships with the outside the region. The current century has been signalled as the age of Asia that is marching forward, beginning of the current century has witnessed the degree of economic progress of emerging powers like China and India. It has significantly surpassing that of the United States and the European Union. The regional economic growth is likely to determine the potential of the current century as ‘Asian Century’. India and China are the two most populous nations globally; geographical neighbours seek global and regional influence through economic progress and a mixed option of ‘soft’ and ‘hard’ power. Limits to India’s traditional influence in South Asian regional politics have been exacerbated by China’s recent expansion of trade, military, diplomatic and developmental ties with countries of South Asian, which challenge the India’s hegemonic traditional influence in the South Asian region. In response, India is developing a new, proactive security policy that seeks to counter Chinese political narratives and infrastructure projects in South Asia. The rivalry between India and China has entered its sixth decade. Although the territorial disputes began in the 1950s, it has become a deep-rooted, enduring rivalry since the 1962 border warfare between the two states. Sino-Indian tensions and suspicions have remained over their disputed border, called LAC (the Line of Actual Control). This study examines the idea of ‘Asian Century dream’ in the context of India-China strategic rivalry. The article is structured into three main parts. The first part outlines the concept of the ‘Asian century dream’, while the second part analyzes the current power politics in Asia. Finally, the third part investigates how the competition between the two major Asian powers affects the realization of the Asian century dream.
Taiwan’s Critical Position in Indo-Pacific: India’s Response to China’s Reactions
Authors: Kaustav Padmapati
Published: July 2023

“China Factor,” has always been a crucial element that shapes India’s attitude towards Taiwan. According to number of China experts, the journey of India- Taiwan relations have happened under the shadow of China only. Taiwan never featured prominently within India’s Act East Policy as always been overshadowed by much bigger Sino-Indian ties. In the last few years, the concept of Indo-Pacific region has received immense political, economic and strategic attention. Undoubtedly, India is among the politically and strategically major players in the region along with China, Japan, Australia, South Korea, the United States and countries of Southeast Asia. Taiwan constitutes a vital component of Indo-Pacific due to its crucial geographical position in the region. To a significant extent, it is also due to the island nation’s critical position in relation to Sino-US relations. Taiwan’s strategic location links the Indian Ocean to the South China Sea and the Sea of Japan. Most importantly, they are used as critical sea routes for exporting and importing of goods worth $ 5.5 trillion annually, according to Center for Strategic and International Studies (CSIS). These routes are extremely important for the import of energy resources to three East Asian countries – China, Japan and South Korea. Since the Indo-Pacific has turned into the center of global dynamism and trade agreements, undisruptive sea lines of communication are crucial for region’s growth and prosperity. However, China’s assertive policies and actions make Taiwan restless and worried. India looks at the Indo-Pacific as an open, libertarian and democratic zone. In the face of assertive China, assessing India’s reaction is crucial as it advocates rules -based, open, balanced liberal order and stable trading environment in the Indo-Pacific region. Being the largest democracy and among the fastest growing economies of the world, it is important for India to acknowledge Taiwan’s democratic position and economic capability. In fact, power dynamics in the Indo-Pacific have recently altered, and it’s the appropriate time for New Delhi to engage more politically and economically with Taiwan.
Analysis and analytical methods in the planning system of health care institutions
Authors: Sysiuk Svitlana , Kyryk Vasyl , Timchev Marko
Published: July 2023

In the article, a critical assessment of the planning system in the field of health care in modern conditions was carried out, a list of plans and their relationship with the management of the activities of a medical institution were identified. It is proposed to strengthen the adaptability of plans to the requirements of the management system; the principles of improvement of the plans were formed (in terms of their standardization and content content). On the basis of the method of generalization and critical analysis, the main problem areas in planning have been identified, for which the application of analysis and its methods will be a reasonable solution. Attention is focused on areas of improvement and the planning algorithm in accordance with the developed author's approach. The development of such an approach is based on an assessment and analysis for the purpose of identifying problems in planning. Thanks to these methods, a study of the indicators of financial provision of health care was also carried out, directions for solving management tasks were formed in terms of improving planning and analytical work. Synthesis, grouping, generalization, comparison was used to identify directions and improve the planning methodology algorithm, including by applying analytical methods in its implementation.

Due to this, using tabular and graphic methods, formalization, an approach to conducting a comprehensive assessment of the current state of activity and resources of the health care entity was formed, and its main stages were described and the necessary comparative indicators were determined. Implementation of the proposed approach makes it possible to improve planning in health care and contributes to the development of real and objective plans for the activities of medical institutions.
Ludotecas para personas mayores: espacios propicios para el fomento del cuidado de enfermería en salud mental
Authors: Farfán Castillo Diego Alexander , Buitrago Gutiérrez Ivonne , Ramírez Gordillo Erika
Published: July 2023

Este artículo busca profundizar en los tipos de ludotecas que existen y cómo podrían convertirse en espacios para la valoración de Enfermería para las personas mayores, donde además se promuevan, mantengan o estimulen sus relaciones interpersonales y consigo mismas (autoconocimiento), en el contexto de las también llamadas jubilotecas, concepto que aún es experimental y sigue en estudio. Lo anterior, basado en la experiencia de las prácticas formativas propias de la Enfermería profesional, la Ruta Integral de Atención para la Promoción y Mantenimiento de la Salud y la Ruta Integral de Atención en Salud de Grupos de Riesgo, normadas en la Resolución 3280 de 2018 y en las cuales se incluyen los aspectos relacionados con la población de interés.
Desnutrición crónica infantil y sus efectos en el crecimiento y desarrollo
Authors: Cortez Figueroa Dorcas Katherine , Pérez Ruiz Marcos Elpidio
Published: July 2023

La desnutrición crónica infantil es un estado patológico ocasionado por Ingesta de alimentos y exigencias nutricionales inadecuados, que se manifiestan en muchos signos clínicos como menor estatura para la edad, menor peso para la estatura Objetivo: Determinar como la desnutrición crónica infantil afecta el crecimiento y desarrollo. Metodología: Se realizo una investigación documental mediante una revisión sistemática de artículos científicos indexados en bases de datos y con una vigencia de 5 años. Resultados: los infantes con desnutrición crónica son de mayor impacto a nivel socioeconómico y sociocultural que afecta la alimentación y el desarrollo de niños y niñas en sus 2 años primeros años de vida. Conclusiones: Se concluyó que el estado de desnutrición del niño menor de 2 años está influenciado por muchos factores de riesgo inherentes al paciente, a la madre y al entorno sociocultural en el que se desenvuelve el niño menor de 2 años y que afectan de manera significativa su crecimiento y desarrollo.
Sosialisasi Sinyal Wasit Berbasis Adobe Flash Dalam Mengedukasi Tim Futsal SMPN 1 Polewali
Authors: Akkase Arfandi , Juhanis Juhanis , Badaru Benny , Latuheru Ricardo Valentino , Sadzali Muhammad , Hamid Muflih Wahid
Published: July 2023

ABSTRACTThe purpose of this service activity is to provide an understanding to the SMPN 1 Polewali futsal team regarding the adobe flash-based referee signals. The method used is by means of training and outreach by holding adobe flash-based referee signal socialization, Participants can receive material with great enthusiasm and willingness so that the material can be absorbed by all participants properly so that this also has an impact on increasing the capacity of SMPN 1 Polewali students in a futsal match.ABSTRAKTujuan kegiatan pengabdian ini yaitu untuk memberikan pemahaman kepada tim futsal SMPN 1 Polewali mengenai sinyal wasit berbasis adobe flash. Metode yang digunakan yaitu dengan cara pelatihan dan sosialisasi dengan mengadakan sosialisasi sinyal wasit berbasis adobe flash, Peserta dapat menerima materi dengan bersemangat dan kemauan yang besar sehingga materi dapat diserap oleh seluruh peserta dengan baik sehingga Hal ini juga   memberikan   dampak   pada peningkatan kapasistas siswa SMPN 1 Polewali dalam pertandingan futsal.
Analisis Kesalahan Morfologis pada Teks Ceramah Karangan Peserta Didik Kelas XI SMA Negeri 1 Losari Brebes Tahun Pelajaran 2020/2021
Authors: Ros Amalia Tian Tifani , Wismanto Agus , Mukhlis Mukhlis
Published: July 2023

The aims of this research was to describe form morphological error in the text a lecture written by students in grade XI of SMA Negeri 1 Losari Brebes for the 2020/2021 school year. The approach in this study uses descriptive qualitative data and data in word form. The data source for this study was  lecture texts from XI SMA Negeri 1 Losari Brebes students for the 2020/2021 school year. The memo method was used to collect data in this study. The obtained data was analyzed using an error analysis technique, and the data analysis results were presented in an informal format. After classification, we obtained data on 61 linguistic errors at  morphological levels consisting of misuses (di prefix, man prefix, ber prefix, ke prefix, kan suffix, suffix and error).ABSTRAKTujuannya penemitian ini adalah mendeskripsikan bentuk kesalahan morfologis pada teks ceramah yang ditulis siswa kelas XI SMA Negeri 1 Losari Brebes tahun pelajaran 2020/2021.  Pendekatan dalam penelitian ini menggunakan data deskriptif kualitatif dan menggunakan data berupa kata-kata. Sumber data dalam penelitian ini adalah teks ceramah siswa kelas XI SMA Negeri 1 Losari Brebes Tahun Pelajaran 2020/2021. Teknik mencatat digunakan untuk pengumpulan data dalam penelitian ini. Data yang diperoleh dianalisis dengan teknik analisis kesalahan, kemudian hasil analisis data disajikan dengan menggunakan metode informal. Setelah dilakukan klasifikasi, diperoleh data 61 kesalahan kebahasaan pada tingkat morfologi, yang terdiri dari kesalahan penggunaan (kesalahan awalan di, awalan men, awalan ber, awalan ke, akhiran kan, akhiran dan kesalahan).
Unsur Intrinsik pada Teenlit The Boy I Knew from Youtube dan A Sky Full of Star sebagai Alternatif Bahan Pembelajaran Apresiasi Sastra di SMA
Authors: Amin Achmad Al , Suciati Sri , Andrian Setia Naka
Published: July 2023

This study aims to describe the intrinsic elements in the teenlit The Boy I Knew From Youtube and A Sky Full of Stars as an alternative material for learning literary appreciation in high school. Data collection in this study is a listening technique and a note-taking technique. The listening technique is used to obtain the data contained in the object of research (teenlit discourse experience). The data obtained were taken from data sources by reading teenlit novels. The results of this study are that both Teenlit The Boy I Knew From Youtube and A Sky of Stars can be used as teaching materials for literary appreciation in high school because the intrinsic elements have special features and story schemes that support and in terms of language, psychology, and socio-cultural backgrounds in these two research studies are very close to the lives of today's youth and raise problems in the youth world with a very communicative style of storytelling.ABSTRAKPenelitian ini bertujuan untuk mendiskripsikan unsur intrinsik pada teenlit The Boy I Knew From Youtubedan A Sky Full of Stars sebagai alternatif bahan pembelajaran apresiasi sastra di SMA. pengumpulan data pada penelitian ini adalah teknik simak dan teknik catat. Teknik simak dipergunakan untuk memperoleh data-data yang terdapat dalam objek penelitian (pengalan wacana teenlit). Data-data yang diperoleh diambil dari sumber data dengan membaca novel teenlit. Hasil penelitian ini adalah kedua Teenlit The Boy I Knew From Youtube dan A Sky of Stars dapat digunakan sebagai bahan ajar apresiasi sastra di SMA karena pada unsur-unsur intrinsiknya memiliki keistimewaan serta skema cerita yang mendukung serta dari segi bahasa, psikologi, dan latar sosial budaya pada kedua teenlit ini sangat dekat dengan kehidupan remaja masa kini dan mengangkat permasalahan di dunia remaja dengan gaya penceritaaan yang sangat komunikatif.
Analisis Gaya Bahasa dalam Antologi Puisi Gus Punk
Authors: Ifriza Falikhatul , Harjito Harjito , Muhajir Muhajir
Published: July 2023

The purpose of this research was to identify the style of language contained in the Gus Punk Poetry Anthology Book. The method used in this study is a qualitative descriptive method with data in the form of phrases, clauses, and sentences in poetry that contain elements of language style. The source of the research data is the Gus Punk Poetry Anthology Book. Data collection techniques in this study are reading and note-taking techniques. While the research instrument, in the form of a human instrument using a sample collection technique from Arikunto. The results of this study were found 16 language styles including euphemism, antonymous style, asindentonian style, personification style, alliteration style, parallelism style, assonance style, eroticism style, correction style, metaphor language style, Erotic language style, asindenton style, apofascist style, repetition style, synecdoche style, and simile style.ABSTRAKTujuan penelitian ini adalah mengidentifikasi gaya bahasa apa saja yang terdapat dalam Buku Antologi Puisi Gus Punk. Metode yang digunakan dalam penelitian ini ialah metode deskriptif kualitatif dengan data berupa frasa, klausa, dan kalimat pada puisi yang mengandung unsur gaya bahasa. Sumber data penelitian berupa Buku Antologi Puisi Gus Punk. Teknik pengumpulan data pada penelitian ini ialah teknik membaca dan catat. Sedangkan instrumen penelitian, berupa human instrument dengan menggunakan teknik pengumpulan sampel dari Arikunto. Hasil penelitian ini ialah ditemukan 16 gaya bahasa diantaranya adalah gaya bahasa eufemisme, gaya bahasa antonomasia, gaya bahasa asindenton, gaya bahasa personifikasi, gaya bahasa aliterasi, gaya bahasa pararelisme, gaya bahasa asonansi, gaya bahasa erotesis, gaya bahasa koreksio, gaya bahasa metafora, gaya bahasa erotesis, gaya bahasa asindenton, gaya bahasa apofasis, gaya bahasa repetisi, gaya bahasa sinekdok, dan gaya bahasa simile.
Nilai Moral dalam Kumpulan Cerpen Yang Bertahan dan Binasa Perlahan Karya Okky Madasari: Kajian Sosiologi Sastra
Authors: Fadhilah Lailatul , Fatimah Siti , Murywantobroto Murywantobroto
Published: July 2023

This study aims to describe how the moral values in a collection of short stories Yang Bertahan dan Binasa Perlahan by Okky Madasari are the study of the sociology of literature. In this study using a qualitative descriptive method. Descriptive qualitative namely research by providing an overview of moral values in the collection of short stories Yang Bertahan dan Binasa Perlahan. The source of the data in this study namely the source obtained from the collection of stories Yang Bertahan dan Binasa Perlahan by Okky Madasari published by Gramedia Pustaka Utama Jakarta consisting of 196 pages and published in 2017, while the data in this study are in the form of words, paragraphs, sentences, and quotes that describe moral values. Data collection techniques using listening and note-taking techniques. Data analysis techniques in this study used content analysis techniques. Based on the research of the short story collection Yang Bertahan dan Binasa Perlahan there are 3 moral value namely the moral value of human relations with oneself, the moral value of human relations with other humans, and the moral value of human relations with God.ABSTRAKPenelitian ini bertujuan untuk mendeskripsikan bagaimana nilai moral dalam kumpulan cerpen “Yang Bertahan dan Binasa Perlahan” karya Okky Madasari: kajian sosiologi sastra. Pada penelitian ini menggunakan metode deskriptif kualitatif. Deskriptif kualitatif yaitu penelitian dengan memberikan gambaran terkait nilai moral dalam kumpulan cerpen Yang Bertahan dan Binasa Perlahan karya Okky Madasari. Sumber data pada penelitian ini yaitu sumber diperoleh dari kumpulan cerpen Yang Bertahan dan Binasa Perlahan karya Okky Madasari yang diterbitkan oleh Gramedia Pustaka Utama Jakarta terdiri dari 196 halaman dan terbit tahun 2017, sedangkan data pada penelitian ini berupa kata, paragraf, kalimat, dan kutipan yang menggambarkan nilai moral. Teknik pengumpulan data menggunakan teknik simak dan teknik catat. Teknik analisis data pada penelitian ini menggunakan teknik analisis isi. Berdasarkan hasil penelitian kumpulan cerpen Yang Bertahan dan Binasa Perlahan terdapat 3 nilai moral yaitu nilai moral hubungan manusia dengan diri sendiri, nilai moral hubungan manusia dengan manusia lain, dan nilai moral hubungan manusia dengan Tuhan.
Senyapan dan Kilir Lidah Guru Bahasa Indonesia dan Dampaknya terhadap Pemahaman Materi Cerita Pendek pada Peserta Didik Kelas XI SMA N 1 Singorojo Kabupaten Kendal Tahun Ajaran 2021/2022
Authors: Setyawati Arum , Suyoto Suyoto , Mualafina Rawinda Fitrotul
Published: July 2023

This study aims to describe the forms of silence and tongue slips of Indonesian language teachers and their impact on understanding short story material in class XI students of SMA N 1 Singorojo, Kendal Regency for the 2021/2022 academic year. The type of research used is a combination of research methods or mixed methods. Based on the research, it was found that there were 29 silences and 5 tongues slips in the Indonesian teacher's learning video for short story material. The existence of the silence and tongues slips did not affect the value of the students, but based on the results of the description test, it was found that there were still students who had not been able to re-explain and describe in their own words the material that had been studied. During the process of understanding the material, the presence of silence and tongues slips disturbs students because students need more time to understand the material because they need to concentrate highly and repeat learning videos.ABSTRAKPenelitian ini bertujuan untuk mendeskripsikan bentuk senyapan dan kilir lidah guru Bahasa Indonesia dan dampaknya terhadap pemahaman materi Cerita Pendek pada peserta didik kelas XI SMA N 1 Singorojo, Kabupaten Kendal tahun ajaran 2021/2022. Jenis penelitian yang digunakan ialah jenis metode penelitian kombinasi atau mixed methods. Berdasarkan penelitian, diperoleh hasil bahwa terdapat 29 senyapan dan 5 kilir lidah dalam video pembelajaran guru Bahasa Indonesia materi cerita pendek. Keberadaan senyapan dan kilir lidah tersebut tidak memengaruhi nilai peserta didik  namun berdasarkan hasil tes uraian, diketahui bahwa masih ada peserta didik yang belum dapat menjelaskan kembali serta menguraikan dengan kata-kata sendiri materi yang telah dipelajari. Selama proses memahami materi, keberadaan senyapan dan kilir lidah menganggu peserta didik sebab peserta didik memerlukan waktu yang lebih lama dalam memahami materi karena perlu berkonsentrasi tinggi dan mengulang video pembelajaran.
ВЛИЯНИЕ ГИДРАТАЦИИ И РАЗМЕРА МАКРОЦИКЛА НАТИВНЫХ ЦИКЛОДЕКСТРИНОВ НА ТВЕРДОФАЗНУЮ ИНКАПСУЛЯЦИЮ РИТОНАВИРА
Authors: Гатиатулин А.К. , Осельская В.Ю. , Климовицкий А.Е. , Зиганшин М.А. , Горбачук В.В.
Published: July 2023

В работе изучено влияние размера макроцикла нативных циклодекстринов и их гидратации на инкапсуляцию ритонавира в условиях механического перемалывания. Разработан способ оценки степени включения ритонавира циклодекстринами, используя кристаллизацию несвязанного «гостя» в продуктах перемалывания при обработке парами воды. Установлено, что ритонавир практически полностью связывается безводными α-, β- и γ-циклодекстринами с образованием соединений включения. Для гидратов циклодекстринов соотношение структура-свойство для связывания ритонавира в зависимости от размера макроцикла «хозяина» является нелинейным. Ритонавир полностью связывается насыщенным гидратом β-циклодекстрина и промежуточными гидратом γ-циклодекстрина. Степень включения ритонавира насыщенными гидратами α-циклодекстрина и особенно γ-циклодекстрина невелика, что обусловлено конкуренцией этого гостя с водой.
SARS-CoV-2 in lions, gorillas and zookeepers in the Rotterdam Zoo, the Netherlands, a One Health investigation, November 2021
Authors: Dusseldorp Florien , Bruins-van-Sonsbeek Linda G.R. , Buskermolen Maaike , Niphuis Henk , Dirven Mariëlle , Whelan Jane , Oude Munnink Bas B. , Koopmans Marion , Fanoy Ewout B. , Sikkema Reina S. , Tjon-A-Tsien Aimée
Published: July 2023

In November 2021, seven western lowland gorillas and four Asiatic lions were diagnosed with COVID-19 at Rotterdam Zoo. An outbreak investigation was undertaken to determine the source and extent of the outbreak and to identify possible transmission routes. Interviews were conducted with staff to identify human and animal contacts and cases, compliance with personal protective equipment (PPE) and potential transmission routes. Human and animal contacts and other animal species suspected to be susceptible to SARS-CoV-2 were tested for SARS-CoV-2 RNA. Positive samples were subjected to sequencing. All the gorillas and lions that could be tested (3/7 and 2/4, respectively) were RT-PCR positive between 12 November and 10 December 2021. No other animal species were SARS-CoV-2 RNA positive. Forty direct and indirect human contacts were identified. Two direct contacts tested RT-PCR positive 10 days after the first COVID-19 symptoms in animals. The zookeepers’ viral genome sequences clustered with those of gorillas and lions. Personal protective equipment compliance was suboptimal at instances. Findings confirm transmission of SARS-CoV-2 among animals and between humans and animals but source and directionality could not be established. Zookeepers were the most likely source and should have periodic PPE training. Sick animals should promptly be tested and isolated/quarantined.
Secret Archives in the Periphery in the 1920s–60s: A Case-Study of the State Archive of the Sverdlovsk Region
Authors:   First President of Russia B. N. Yeltsin Ural Federal University, Sverdlovsk Region, Russian Federation, Ogurenko Egor V.
Published: July 2023

This article discusses the problem of information culture in the Soviet society on the example of development of classified documents storage in state archives from late 1930s to mid-1960s. After sociopolitical transformations of 1917–20, archival documents became a political (informational) resource due to “mobilization” atmosphere in society and government circles. It was the political police authorities who were most interested in unrestricted access to the documents of the Unified State Archive Fond (GAF). The system of secret archives evolved in 1924 as a form of monopolization of information sphere. The activity of regional secret archives was aimed at preservation, registration, and use of restricted access documents. Materials containing data on personal composition and activities of pre-revolutionary and some Soviet state institutions were classified. Using the activities of the secret fonds department of the State Archive of the Sverdlovsk Region (GASO) as example, the author analyzes the entire spectrum of work of regional secret archives: organization, material and technical support, areas of work, and staffing. An important aspect of the secret archives’ activities were “operational and Chekist activities”: preparation of reference and information documents for the regional bodies of the Joint State Political Directorate (OGPU) and, later, the People’s Commissariat for Internal Affairs (NKVD). Operative and security work of massive proportions began in 1938, when all state archives became part of the NKVD, reaching its peak during the Great Patriotic War (1941–45). During the same period, an attempt was made to request more complex information documents from regional archival bodies. In the post-war period, work with secret documents continued until 1956, when the process of declassification of the GAF documents was officially initiated. Secret fonds departments of state archives continued to inform the special services until their abolition in 1965. The secret storage in the Sverdlovsk Region existed until 1988, when the last secret fonds were declassified. The author concludes that longevity of this specific form of work with such a small part of retrospective documentation was dictated by the peculiarities of the Soviet society development. This research is based on materials from the State Archives of Sverdlovsk Region.
“…To Be among the Builders of Socialism.” Revisiting the Political Biography of the Former Member of the Executive Committee of the “Narodnaya Volya” M. F. Frolenko (1935)
Authors:   Institute of History, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation, Morozova Tatiana I.
Published: July 2023

The article presents unique documents newly discovered in the Russian State Archive of Contemporary History (RGANI) and draws on them to reconstruct the circumstances of M. F. Frolenko (1848–1938), one of the oldest Russian revolutionaries, former member of the “Narodnaya Volya” and pensioner of republican level, joining the All-Union Communist Party (Bolsheviks). It focuses on M. F. Frolenko’s letter of application addressed to the General Secretary of the Central Committee of the AUCP (B) J. V. Stalin, recommendation letter of the secretary of the party collegium of the Party Control Commission under the Central Committee of the AUCP (B) E. M. Yaroslavskii, and extract from minutes of meetings of the Bureau of the Party Control Commission under the Central Committee of the AUCP (B) dated November-December 1935. The introduction argues the relevance of topic and characterizes broad historical context, necessary for understanding the essence and significance of the published materials. It shows that M. F. Frolenko was not only organizer and participant of several assassination attempts on Emperor Alexander II, but one of the few members of the Executive Committee of the “Narodnaya Volya,” who, despite his arrests and katorga, lived long enough to see the collapse of the Russian monarchy. For 18 years following the establishment of Soviet power, participation of M. F. Frolenko in the socio-political life of the country was limited to public speaking to working youth and students and his membership in the All-Union Society of Political Prisoners and Exiles. Low-profile political activity of M. F. Frolenko may be explained by his advanced age, poor health, and Bolsheviks’ distrust of members of other parties. In the first years after their coming to power, Bolsheviks willingly received former socialists, if they joined the party; however, starting from the mid-1920s, the top party leadership had raised the requirements for this category at least twice. As a result, by the mid-1930s the AUCP (B) almost completely barred members of other political parties from joining it. The more surprising was decision of 87-year-old M. F. Frolenko, who remained nonparty all this time, to become the member of the AUCP (B) in November 1935. The hypothesis suggests itself, that it was initiated by the party leadership. Higher ranks of Bolsheviks wanted M. F. Frolenko to recognize the successes of socialist construction and correctness of the general line of the AUCP (B) publicly. Soon, in 1936, it laid foundations for the concept of “complete ideological defeat of narodnichestvo” formulated by E. M. Yaroslavsky.
The Tikhvin Old Believer Almshouse in the Second Half of the 18th – First Half of the 19th Century
Authors:   National Museum Complex in Veliky Novgorod, Veliky Novgorod, Russian Federation, Melnikov Ilya A.
Published: July 2023

The article highlights the history of establishing and functioning of the Old Believer almshouse of the Pomorian congregation, operating in the city of Tikhvin since 1764. In some sources, it is called “monastery” and “skete,” as nuns lived there. The main sources used in the article are documents stored in the Russian State Archive of Ancient Acts and in the Russian State Historical Archive; most are being thus introduced into scientific use. Among the identified documents are decrees and petitions related to the monastery establishing and its property acquisition in the 18th – early 19th century. The sources demonstrate the role of the Tikhvin Old Believer almshouse in maintaining ties with Old Believer spiritual centers in the Olonets gubernia, St. Petersburg, and Moscow. The skete housed locally revered relics: miraculous icons, relics of saints (some from Novgorod). Old Believers from other regions came to worship them, especially during the Tikhvin spring fair. There were active contacts between Tikhvin and Vygovskaya Old Believer community. The skete also promoted consolidation of the uezd inhabitants, gathering in Tikhvin to worship local shrines, to perform repentance, to make a prayer (nachala) for non-observance of the Old Believer rules, which was important for the priestless communities: thus, they returned to the community by the decision of the skete council of spiritual mentors. The article focuses on tragic closing of the prayer house and almshouse and its rearrangement into edinovertsy church. It happened during government repressions against the Old Believers in 1854. The Tikhvin Edinovertzy Church, founded by the Ministry of Internal Affairs official Yu. K. Arseniev, was the first in the Novgorod eparchy, antedating similar developments in the region. The success of this Ministry project sprang from readiness of the officials to forcibly take control of relics and locations sacred to the Old Believers (monastery’s revered icons, including those with relics, its cemetery with its prayer house, where the ancestors of the Tikhvin Old Believers were buried).
Prosopographic Portrait of Senior Officials of the RSFSR People’s Commissariat for Justice in the Days of the Great Patriotic War of 1941?45: Documents from the RGASPI and the GARF
Authors:   Higher School of Economics, Moscow, Russian Federation, Rybakov Vladislav A.
Published: July 2023

In reference and research publications there is almost no information on most heads of the republican justice administration body, the RSFSR People’s Commissariat for Justice (PCJ RSFSR), of 1941?45. This is largely due to limitations of the source base and secondariness of republican bodies in the USSR. Meanwhile, during the war, the republican justice administration bodies were endowed with great powers. Not only they monitored the activities of the courts and correctness of their application of legislation, but also issued secret instructions of illegal nature. In this regard, the identity of their heads, who held such powers and had such impact on court practice, is of great importance. The article draws on party nomenclature accounting records from the Russian State Archive of Socio-Political History (RGASPI) to reconstruct official biographies of two people’s commissars for justice of the RSFSR and four their deputies. The prosopographic method has permitted to create a collective portrait of senior officials of the republican administrative justice bodies in the period between two personnel purges of the Soviet justice system – prewar one and postwar one. According to the documents, the nominees who took senior positions in the PCJ RSFSR on the eve of the war were relatively young and from “correct” social background. In the nomenclature system their lack of professional education and experience was compensated by their Bolshevik affiliation, following the main trend of the Stalinist personnel revolution. The official biographies of nomenclature establishment, as well as presence of odious figures and persons with dubious reputations among the PCJ RSFSR senior officials allow the author to conclude that appointment of nomenclature personnel to the republican People’s Commissariat for Justice by residual principle eroded its authority. Their lack of professionalism and practical experience had a direct impact on the activities of the PCJ RSFSR under the extreme war conditions. In the purge of the justice system in 1947?52, the establishment of the republican People’s Commissariat for Justice lost their posts. Thus, senior officials of the PCJ RSFSR repeated the fate of their prewar predecessors, but unlike the latter, they were not repressed.
Water Quality Analysis at Goiana-PE Basin
Authors: Bessone de Almeida Alicya Izabelle Melo , Fernandes Emanuel Félix , De Melo Guilherme Henrique Santos , Da Silva Victor Júlio Alexandre , Galvíncio Josiclêda Domiciano
Published: July 2023

Os recursos hídricos são utilizados em diversos setores da sociedade como a indústria, gerando impactos nos sistemas naturais e nos processos biológicos. Este artigo busca analisar a qualidade da água na Bacia do Rio Goiana - Pernambuco, considerando variáveis como a temperatura e a concentração de elementos como Nitrato e Fósforo, além da análise climatológica. Foi utilizado o Sistema de Unidade de Resposta Hidrológica de Pernambuco-SUPer. Os resultados mostraram que há um aumento considerável da poluição na bacia devido à ação antrópica.Water Quality Analysis at Goiana-PE BasinAbstractWater resources are used in various sectors of society such as industry, generating impacts on natural systems and biological processes. This article seeks to analyze the water quality in the Goiana River Basin - Pernambuco, considering variables such as temperature and the concentration of elements such as Nitrate and Phosphorus, in addition to the climatological analysis. The Hydrological Response Unit System for Pernambuco-SUPer was used. The results showed that there is a considerable increase in pollution in the basin due to anthropic action.Keywords: Water quality, Water resources, Pollution.