bluuebunny/crossref_metadata_2025 huggingface dataset:
Problematic of Using а Blended Learning in Teaching the Discipline "Hygiene and Ecology"
Authors:   Kharkiv State Medical University. 4 Nauky Avenue, Kharkiv, 61022, Ukraine, Zavgorodnii І. V. , Merkulova T. V. , Litovchenko O. L. , Lysak M. S.
Published: October 2021

Every year the rate of spread of new educational models in higher education is increasing. This leads to a change in the trajectory of the educational environment towards the active use of Internet technologies. At the present stage, in order to qualitatively update the content of education, a polyparadigmatic approach to the choice of pedagogical technologies with a combination of different teaching methods, flexible educational models and styles is needed. This is a "blended learning" – modern technology that has broad prospects for use and further development, attracts the student and allows you to study according to an individual educational trajectory. The article highlights the features of the introduction of elements of blended learning in mastering the discipline "Hygiene and Ecology" by the 6th-year students of the Medical University. The purpose of the study was to determine the features of the use and ways of further improving the blended learning model in teaching the discipline "Hygiene and Ecology". Materials and methods. The methodological basis of the research is the concept of student-centered learning, theory, principles and own experience of using information systems in the implementation of a blended learning model. Results and discussion. The study highlights the main positive benefits of blended learning compared to traditional classroom learning. As a result of the study, it was established that when studying the discipline "Hygiene and Ecology" it is advisable to use the "inverted class" technology, which has a positive effect on the level of learning the material. At the same time, teachers faced the need for a clear structuring and distribution of topics for self-study by students and mandatory mastering within the classroom work in the study of this discipline. The introduction of elements of blended learning in mastering the discipline led to an increase in the pedagogical load in terms of the teacher's performance of significant amounts of methodological work, the search for adequate and relevant sources of scientific and medical information, actualized the need to create a unified methodological system in the institution. Conclusion. Problems that require a gradual solution on the way to the effective use of blended learning opportunities at a medical university are the organization of continuous training for teachers to develop their digital competencies, active promotion of the use and creation of open information resources, the distribution of the percentage of students' independent work and the labor intensity of classroom work in the network
Assessment of the Mental Working Efficiency of Teachers of Different Categories and Specializations
Authors:   Sumy State Pedagogical University named after A. S. Makarenko. 87, Romenska Str., Sumy 40002, Ukraine, Latina H. O. , Kalynychenko D. O.
Published: October 2021

The relevance of the study is confirmed by the sustainable development goals of the United Nations General Assembly resolution "Transforming Our World: An Agenda for Sustainable Development until 2030". The third goal is “good health and wellbeing”. It aims to ensure healthy lifestyles and promote well-being for all at all ages. Therefore, caring for the professional well-being of teachers through the diagnosis of pathological conditions is the first task in the field of occupational health. The purpose of the study is to assess the weekly dynamics of the mental performance of teachers of different pedagogical categories and professional groups. Materials and methods. To study the mental performance of teachers, the method of dosed assignment according to the tables of V. Ya. Anfimov was used. 51 teachers of three age groups were examined: 31-40 years old (16 people), 41-50 years old (20 people), 51 and above (15 people) of institutions of general secondary education. Results and discussion. The dynamics of teachers' mental performance in terms of attention indicators is characterized by an increase in the level of performance at the end of the working week. Friday's job performance significantly outweighs Monday and Wednesday job performance. The performance curve in terms of the performance of teachers of different age groups corresponds to the general dynamics. A significant difference was established between the indicators of the coefficient of work productivity in all age groups at the end of the working week Age differences in the dynamics of mental performance are formed due to an increase in the number with a decrease in the quality of the work performed by teachers of the older age group at the end of the working week. Such dynamics corresponds to the age-related dynamics of the development of human working capacity and demonstrates the compensatory effect of professional experience on the age-related stabilization of the reliability of mental activity. Conclusion. The weekly dynamics of the mental performance of teachers depends on the level of the pedagogical category; in particular, the optimal weekly dynamics is inherent in teachers of the first category. The performance of teachers in different professional fields differs. An increase in the volume of attention by the end of the week (p <0.05) and a tendency to an increase in the accuracy indicator in the middle of the week among teachers of philological subjects, mathematics and primary grades were found. High work intensity at the end of the week, accuracy – at the beginning of the working week (p <0.05) for biology and chemistry teachers. Prospects for further research are in the analysis of indicators of mental performance of teachers, depending on the intensity of the labor process
Improving the Training of Qualified Athletes-Students by Modern Nutritiological Technologies
Authors:   Olympic Institute of National university of physical training and sport of Ukraine. 1, Fizkultury St., Kyiv 02000, Ukraine, Gunina L. M. , Milashius K. M. ,   Vytautas Magnus University. 58, K. Donelaičioб Kaunas 44248, Lietuva, Chernozub A. A. ,   Petro Mohyla Black Sea National University. 10, 68 Desantnykiv St., Mykolaiv 54003, Ukraine, Danylchenko S. I. ,   Petro Mohyla Black Sea National University. 10, 68 Desantnykiv St., Mykolaiv 54003, Ukraine, Voitenko V. L. ,   Medical Institute of Sumy State Univercity. 31, Sanatorna St., Sumy 40018, Ukraine
Published: October 2021

Currently, a significant part of highly qualified athletes are students of higher educational institutions at the same time, which manifests itself not only in an ultra-high level of physical activity, but also in significant psycho-emotional stress. Therefore, the search and introduction of modern technologies in the process of sports training, including pharmacological, hygienic, rehabilitation, etc. are continuing. An essential place among such technologies is occupied by a comprehensive methodology of nutrition-metabolic support of the training process, built on the principles of evidence-based medicine and using the latest achievements of laboratory and functional diagnostics, biochemistry and pharmacology. The purpose of the study is the formation of ideas about the necessity, validity and effectiveness of nutritive-metabolic support of the process of sports training of students of higher education institutions. Nutrition-metabolic support is part of a sporting nutritiology that possesses all the features of basic science – terms, definitions, and at the same time has great practical significance, helping to form relevant and well-grounded programs of nutrition-metabolic support of the training and competitive process of athletes, as well as to contribute to preservation the health and quality of life of athletes. This position is particularly important in student sports, where the body of an athlete is exposed to additional stressors due to the complexity of the need for a rational and effective combination of the educational and training process of highly qualified athletes. Conclusion. The applied nutritive-metabolic technologies such as methods of metabolic support of motor activity should take into account the specialization and qualifications of athletes, their gender-age characteristics and should be applied depending on the training period and the orientation of the loads. In connection with the improvement and tightening of doping control, it is extremely important that sports nutrition products and special nutritional supplements that are widely used to optimize the functional state of the athlete's body and maintain their health and quality of life do not contain substances related to the World Anti-Doping Agency Prohibited List, while ensuring a pronounced ergogenic effect
Increase of the Physical Condition of Female Students by Means of Health Swimming
Authors:   Zaporozhye National University. 110а, Soborny Avenue, Zaporozhye 69095, Ukraine, Ivanska O. V.
Published: October 2021

The purpose of the study was to substantiate the experimental program of sectional classes with the complex use of recreational swimming means for female students of higher education institutions, which is aimed at increasing their physical condition. Materials and methods. Female students of 18-19 years old of higher education institutions took part in the research. During the study such methods were used: theoretical analysis of scientific and methodological literature, summarizing scientific data from modern approaches to the organization of the system of physical education of students of higher education institutions, general physical fitness testing. To assess the level of physical performance, the PWC170 submaximal test and the Rufier-Dixon test were used. Results and discussion. A program of sectional lessons with the integrated use of health-improving swimming means for female students of 18-19 years old of higher education institutions is proposed, which provides for a rational distribution of physical education means and rationing of the volume and intensity of physical activity. It was proved that after the experiment, the examined girls showed a significant (p <0.05) increase in the level of physical performance by 9%, dynamometry of the right hand by 6.5%, strength of the abdominal muscles by 5% and results in agility and flexibility tests, respectively 0.65% and 7%. At the same time, changes in other indicators were not statistically significant. The data indicate the positive influence of health-improving swimming sectional classes on the physical condition of 18-19-year-old female students. Conclusion. The introduction of the developed program of sectional classes with the integrated use of recreational swimming into the system of physical education of 18-19-year-old girl students contributed to a significant improvement of their physical condition. So, at the time of the end of the annual sectional classes according to the author's program, girls in the experimental group were found to have significantly (p <0.05; p <0.01; p <0.001) higher values of their physical performance, physical fitness, functional state of the cardiorespiratory system, physical health. The results obtained in the course of the formative experiment testify to the high efficiency of the developed program of sectional lessons for female students of 18-19 years old with the integrated use of recreational swimming, which gives grounds to recommend it for practical implementation in the system of physical education of students of higher educational institutions
Trends in Russia’s GDP Growth under Environmental Constraints
Authors: Bragina Z. V. , Denisov A. R. , Masyuk N. N. , Steblyanskii N. V.
Published: October 2021

The paper illustrates an approach to GDP growth in the context of an ecological economy. The subject of the research is the establishment of the interdependence of the state of the ecology of the environment and the results of human activity. The aim of the study is to determine the presence or absence of a relationship between pollutants in each type of environmental pollutants and the level of economic development of the country, represented by GDP per capita indicators. The relevance of the study is due to the ecologically unbalanced growth of GDP, which is accompanied by an increase in disproportions between the volume of pollutants emitted by the extractive, processing, processing, agricultural and infrastructure sectors of the economy, and the conditions of human life due to the deterioration of the “ecological quality” of the environment, which limits the possibilities for further development of human capital. The scientific novelty of the research lies in the development of economic and mathematical models, methods, and numerical algorithms for assessing and analyzing the state of air, water, and environmental pollution under the influence of the country’s economic growth. Methods used: empirical and statistical analysis, building regression models, algorithmic and predictions, building time trends, etc. The authors based the methodology of substantiating the method for assessing the environmental constraints on GDP growth on an empirical study of the state of the environment and the state of the Russian economy in 2000–2018. Results: the authors have determined a set of indicators reflecting the state and trends of changes in environmental pollutants in Russia (carbon dioxide emissions, wastewater, production, and consumption waste) and their interdependence with economic development, which predetermine long-term social, environmental, and energy consequences. An algorithm has been developed to substantiate environmental restrictions on Russia’s GDP growth in the period 2000–2018. The algorithm is based on a modified Kaya equation, through which the relationship between each type of pollutant and indicators of GDP per capita, energy resources, and industrial production is checked. In accordance with GDP growth, the forecast of environmental restrictions was developed according to scenarios of 10–40% and showed the inevitability of implementing a plan to prevent environmental pollution in Russia. It is concluded that Russia must promote environmental and low-carbon policies, reduce emissions, waste, and energy consumption over the next few decades to achieve sustainable development. The country is faced with the task of moving away from a nature-destroying economy, thereby saving natural capital, minimizing the costs of eliminating the negative environmental consequences of technogenic economic development in the future.
Prospects for the Integration of Google Trends Data and Official statistics to Assess social Comfort and Predict the Financial situation of the Population
Authors: Shakleinaa M. V. , Volkova M. I. , Shaklein K. I. , Yakiro S. R.
Published: October 2021

This paper aims to develop a theory of statistical observation in terms of scientific and methodological approaches to processing big data and to determine the possibilities of integrating information resources of various types to measure complex latent categories (using the example of social comfort) and to apply this experience in practice through the use of the financial situation indicators in forecasting. The authors have built a social comfort model in which the choice of weights for its components is based on a modified principal component analysis. The assessment is based on Google Trends data and official statistics. Google Trends data analysis methods are based on the development of an integrated approach to the semantic search for information about the components of social comfort, which reduces the share of author’s subjectivity; methodology of primary processing, considering the principles of comparability, homogeneity, consistency, relevance, description of functions and models necessary for the selection and adjustment of search queries. The proposed algorithm for working with big data allowed to determine the components of social comfort (“Education and Training”, “Safety”, “Leisure and free time”), for which it is necessary to directly integrate big data in the system of primary statistical accounting with further data processing and obtaining composite indicators. The authors conclude that a stable significant correlation has been found for the “Financial Situation” component, which makes it possible to use it for further calculations and extrapolation of financial indicators. The scientific novelty lies in the development of principles and directions for the integration of two alternative data sources when assessing complex latent categories. The findings and the results of the integral assessment of social comfort can be used by state statistics authorities to form a new type of continuous statistical observation based on the use of big data, as well as by executive authorities at the federal, regional and municipal levels in terms of determining the priorities of socio-economic policy development.
The Venture Capital Market in a Pandemic: Realities of Time and Future Prospects
Authors: Ezangina I. A. , Malovichko A. E.
Published: October 2021

The subject of the research is the financial mechanism of the modern venture investment market under conditions of uncertainty and the requirements of accelerated innovative development. The study aims to analyze the impact of the pandemic on the sustainability of the institutional behavior of venture capital investment in the global and Russian markets. The authors apply such scientific methods as sampling, grouping, comparison, analogy, analysis, generalization, systemic-structural approach to assessing the development of the subject of research. The paper analyses the role of venture investment in the successful promotion of innovations using the example of the world’s leading companies in 2016–2021. Successful examples of venture investment are presented. The study investigates the impact of the pandemic and lockdown on the level of volatility, composition and dynamics of venture capital investments in 2020– 2021. The authors conclude that the pandemic has an impact on the sectoral redistribution of investments in favor of venture investments in medicine, biotechnology, the sector of information and communication technologies and solutions for business, education, healthcare, on market polarization (covid-negative, covid-positive, covid-neutral), on reducing the role of state funds and Russian accelerators, while increasing the interest and scale of participation of private institutions (foreign investors, business angels, syndicated angel investment), to increase of the volume of the Russian venture capital market by increasing the average ticket size despite the reduction in their number, to strengthen the practice reproduction of their own ecosystems by corporate institutions, to popularize venture capital investment deals in terms of mergers and acquisitions. Prospects for researching the venture capital market are associated with the constant attention to high-tech covid-positive projects, with the growth of transactions in the early stages, due to the increase in the number of professional communities, with the pinpoint development of specific tasks of an investor or corporation by accelerators, with venture investment of companies with the subsequent entry of the project into their own ecosystem, with the improvement of the state’s restrictive measures aimed at a clear institutionalization of professional activities and increasing the financial stability of participants in the investment and innovation markets, with the stimulation of mechanisms for regional innovative development to attract capital to high-risk projects in the regions.
The Combination of Dasatinib and PD L1 inhibitor prevents the progression of epithelial mesenchymal transition and dramatically blocks cell invasion of HER2 positive breast cancer cells
Authors: Kheraldine Hadeel , Gupta Ishita , Cyprian Farhan , Vranic Semir , Al Moustafa Ala-Eddin
Published: October 2021

Introduction: Both Dasatinib (DA), a tyrosine kinase inhibitor that is used for targeted cancer therapy, and programmed death-ligand 1 (PD-1/PD-L1) inhibitor that is an immune checkpoint therapy, play a vital role in the management of several types of solid tumors, including breast. Nevertheless, the combined outcome of DA and PD-1/PD-L1 inhibitors in human carcinomas has not been explored yet. Materials and methods: We herein compared the individual impact of DA and PD-1/PD-L1 inhibitors (BMS-202) with their combination on two human HER2-positive breast cancer cell lines, SKBR3 and ZR75. Results: Our data revealed that the combination of DA and BMS-202 significantly inhibits cell proliferation in both cell lines as compared to mono treatment and/or untreated cells. Moreover, we observed that combination treatment prevents the progression of “epithelial-mesenchymal transition” (EMT), which is a hallmark of cell invasion and cancer progression. Our data reveal that DA and BMS-202 together dramatically inhibit cell invasion of SKBR3 and ZR75 cells; this is accompanied by the up-regulation of E-cadherin and its restoration along with b-catenin on the cell membrane and its undercoat, respectively, in addition to the downregulation of vimentin, which are major markers of EMT. Additionally, we found that the synergistic treatment of DA and BMS-202 inhibits colony formation of both cell lines in comparison with their matched control. Conclusion: Our findings implicate that, in comparison to monotreatment, combination of DA and BMS-202 could have a significant impact on the management of HER2-positive breast cancer via HER2 inactivation and specifically b-catenin signaling pathways.
Habitual tea and coffee consumption and mean reaction time among Qatari adults
Authors: Heggy Alaa Jaber , Masoumi Aisha Ali , Alyafei Maryam saed , Al-Bader Fatima Ebraheem , Al-Abdi Tamara , Shi Zumin
Published: October 2021

Background: Tea and coffee consumption is associated with cognitive function in some studies. We aimed to identify tea and coffee drinking patterns and their association with mean reaction time among Qatari adults. Method: The study included 1000 adults aged 20 years and above attending the Qatar Biobank Study (QBB). Habitual tea and coffee consumption during the previous year was assessed by questionnaire. Tea and coffee drinking patterns were identified using factor analysis. In a computer-based self-administered touch screens test, mean reaction time (MRT) was used as an indicator of cognitive function. Results: The mean age of the participants was 35.8 (SD 10.3) years. Herbal tea and regular coffee consumption was inversely associated with MRT. In the multivariable model, compared with non-consumers, the regression coefficients for MRT were -34.34 (-65.36,-3.33) and -37.85 (-71.03,-4.67) for daily consumers of herbal tea and regular coffee, respectively. Of the two tea and coffee drinking patterns identified, pattern 1 (high consumption of tea, Arabic coffee, and herbal tea) was not associated with MRT but pattern 2 (high loadings of instant coffee, regular coffee and Karak) was inversely associated with MRT in the unadjusted model. There was a significant interaction between pattern 2 and LDL in relation to MRT. Pattern 2 was inversely associated with MRT among those with a low LDL.Conclusion: There was an inverse association between regular coffee and herbal tea consumption with mean reaction. There was an interaction between Western coffee pattern and LDL.
Comparison of Available Methods for Investigating The in vitro Activity of Colistin Against Different Gram-Negative Bacilli
Authors: Shams Noora , AlHiraky Hanin , Moulana Nabila , Riahihi Maissa , Alsowaidi Kaltham , Albukhati Khawlah , Zughair Susu , Eltai Nahla
Published: October 2021

Background: The surge in the prevalence of multidrug-resistant (MDR) Gram-negative bacterial infections with limited treatment options and the decrease in the development of new antibiotics are challenges that lead to the reuse of colistin to treat infections caused by MDR pathogens. This study aimed to determine economical, simple, and reliable colistin susceptibility testing methods as an alternative to the time and effort-consuming microdilution technique and identify the colistin resistance's genetic determinants to find if it affects the testing method. Material and Methods: Seven colistin susceptibility testing methods, namely, Disk diffusion, E-test, ComASPTM SensiTest, broth disk elution, colistin agar test, CHROMagarTM COL-APSE, and BD Phoenix ID/AST, were compared to the gold standard broth microdilution. Data of the 63 studied isolates were analyzed using very major error (VME), major error (ME), categorical agreement (CA), sensitivity, specificity, Kappa, positive and negative predictive values. Whole-genome sequencing was performed on all isolates to determine if the genetic resistant factors affect the accuracy of the specific colistin susceptibility testing method. Results: Our results revealed that disk diffusion is still an ineffective method for measuring colistin susceptibility with the highest ME (31.75%), the lowest Kappa 0 (0%), and CA (68.25%) values. In contrast, the highest sensitivity, specificity, CA, kappa value, positive and negative predictive values were reported on Phoenix, ComASPTM sensitest, and E-test methods compared with the microbroth dilution reference method. Our study did not ensure any relation between the type of colistin resistance genetic determinant (chromosomal/plasmid-mediated) and the performance of the specific colistin susceptibility test Conclusions: Phoenix, E-test, and CompASPT SensiTest methods have remained superior in reproducibility, sturdiness, simplicity of use with a performance similar to the current recommended BMD procedure. These methods can be an alternative to the current laborious, impractical broth microdilution technique, especially in microbiology laboratories with a large workload.
Reno-Protective Effects of Angiotensin Receptor Blockers in Hypertensive Rodent Models: A systematic review
Authors: Hamed Marwa Ibrahim , Al-Dakhakhny Salma , Rathore Hassaan , Ibrahim Mohamed Izham Mohamed
Published: October 2021

Background and objective: Essential hypertension is a leading risk factor for chronic kidney disease, yet there is no conclusive evidence that lowering blood pressure alone improves renal outcome measures. Angiotensin-II receptor blockers (ARBs) proposed to have renal-protective effects independent of their antihypertensive effect. This systematic review of animal studies aims to collect available information from the published literature about the ARBs' consequences in murine models and analyze it in a structured way to provide a pre-clinical baseline for future analysis of similar clinical investigations. Methods: Following the PRISMA checklist, we conducted a systematic review for quasi non-randomized controlled studies using PubMed, Embase, Science-Direct, SCOPUS, and Google Scholar to determine the effects of ARBs on kidney functions. Eligible articles report the ARBs' effect on proteinuria, albuminuria, and glomerular filtration rate in murine models of hypertension. Outcomes were present as Mean ± Standard Error of Mean (SEM) with 95% confidence intervals (CIs). Results: This preliminary analysis includes ten out of 56 total eligible articles after quality assessment, reporting twelve renal outcome measures. Two studies showed improvement in CrCl versus one study showing no difference. Four out of five studies showed a reduction in proteinuria compared to the control group. All three studies showed a significant reduction in albuminuria compared to control and other antihypertensives. A study Evaluating BUN showed no difference. Nine outcomes supported the reno-protective effect of ARBs on different hypertensive models with various ARBs and different follow-up durations. Low dose valsartan 10mg/kg was showing no significant effect across two different studies. Conclusion: Preliminary results are encouraging. ARBs contribute to improvement in renal biomarkers in different hypertensive models regardless of their BP-lowering effect.
Examination of Job Satisfaction, Achievements, and Employment Preparedness among College of Pharmacy Alumni: A Study From Qatar
Authors: Al-Hathal Turfa Awrans , Al-Ghazal Lolwa , Mukhalalati Banan , Awaisu Ahmed , El-Awaisi Alla , Mraiche Fatima , Diab Mohammad , Stewart Derek , Elshami Sara
Published: October 2021

Background: Job satisfaction in healthcare is of special interest as has a direct relation with the quality of care provided to patients. It is affected by several factors including the nature of the work, level of educational preparedness and achievements. Objectives: This study aims to explore College of Pharmacy - Qatar University (CPH-QU) alumni’s satisfaction with employment and the profession, level of educational preparedness and achievements in the practice. Methods: A sequential exploratory mixed-method designs was adopted. Seven Focus Group (FG) discussions were performed and a self-reported survey distributed to all alumni graduated between 2011-2020. Results: A total of 135 alumni answered the survey (response rate 63%). Majority of respondents were non-Qatari (97%) and 52% of them were recent graduates and obtained doctor of pharmacy (PharmD) as an additional degree (58%). The study findings suggest that CPH alumni are moderately satisfied with the practice and the profession, and Qatari alumni are more satisfied. However, majority of them (44.55%) are not satisfied with the available opportunities for professional development. The level of satisfaction about achievements was significantly high only in the field of research and presentation activities. A general agreement about the level of educational preparedness was dominant, especially in clinical knowledge and skills and experiential training they received. Conclusion: The overall satisfaction about workplace and the profession in CPH-QU alumni is moderate and higher among Qatari graduates. Alumni agreed that they were well prepared to meet the practice requirements and mostly satisfied in achieving research and presentation related activities.
Artificial Intelligence in Predicting Heart Failure
Authors: Al-Mannai Rashid Ebrahim , Almerekhi Mohammed Hamad , Al-Mannai Mohammed Abdulla , N Mishahira , Sadasivuni Kishor Kumar , Yalcin Huseyin Cagatay , Ouakad Hassen M. , Bahadur Issam , Al-Maadeed Somaya , Albusaidi Asiya
Published: October 2021

Heart Failure is a major chronic disease that is increasing day by day and a great health burden in health care systems world wide. Artificial intelligence (AI) techniques such as machine learning (ML), deep learning (DL), and cognitive computer can play a critical role in the early detection and diagnosis of Heart Failure Detection, as well as outcome prediction and prognosis evaluation. The availability of large datasets from difference sources can be leveraged to build machine learning models that can empower clinicians by providing early warnings and insightful information on the underlying conditions of the patients
Burnout and Resilience in Community Pharmacists in Qatar during the COVID-19 Pandemic: a Cross Sectional Study
Authors: Alkudsi Zeana Samir , Kamel Nadin Hany , El-Awaisi Alla , Shraim Mujahed M A , ElHajj Maguy
Published: October 2021

Objective: The main aim of this study is to illustrate the prevalence of burnout and resilience among community pharmacists in Qatar during the COVID-19 pandemic. Methods: This is a cross-sectional study design that included the collection and analysis of quantitative data from community pharmacists in Qatar using a cross-sectional survey. Results: Overall, participants had a moderate level of burnout as illustrated in the mean scores of the three dimensions; 22.11±13.053 for emotional exhaustion, 7.17±6.55 for depersonalization, and 35.94±11.47 for personal accomplishment. The findings demonstrated that 15.2%, 15.6%, and 5.4% of community pharmacists had moderate levels of depression, anxiety, and stress, respectively. Further, they showed high resilience (35.7±8.57). Mental health outcomes were statistically positively correlated with fear while age was negatively correlated with depersonalization. Conclusion: This study is the first study to report the prevalence of mental health outcomes among community pharmacists during COVID-19 in Qatar. The pharmacists experienced moderate burnout but high resilience which indicates their high potential to overcome difficulties. Future interventions at the personal, national and organizational levels are needed to improve mental health during this pandemic by preventing and managing stress, improving self-efficacy and resilience, and providing adequate social support.
Pyocyanin pigment from Pseudomonas aeruginosa modulates innate immune defenses in macrophages
Authors: Mahgoub Yasmine , Arif Rida , Zughaier Susu
Published: October 2021

Background: Pseudomonas aeruginosa is a well-known opportunistic pathogen. The gram-negative bacillus, commonly associated with hospital-acquired infections, utilizes the host’s impaired immune responses to establish infection. Of its many virulence factors, pyocyanin is essential for P. aeruginosa to establish its full infectivity. Macrophages act as sentinels of the innate immune system, as well as play other roles in homeostasis, tissue remodeling, and bridging between the innate and adaptive immune systems. Aim: This study aimed to investigate the effects of pyocyanin on macrophage innate immune defenses by assessing the function of macrophages treated with pyocyanin and TLR ligands. Phagocytosis of opsonized zymosan, LPS-induced nitric oxide release and cytokine release were used as measures of functional responses. Results: This study found that pyocyanin inhibited phagocytosis-induced ROS release in a dose-dependent manner and reduced nitric oxide release from macrophages induced with P. aeruginosa LPS. In addition, pyocyanin modulated cytokines and chemokines release from macrophages exposed to P. aeruginosa LPS in a dose-dependent manner. Pyocyanin significantly enhanced IL-1β release as well as several chemokines. Therefore, pyocyanin facilitates Pseudomonas aeruginosa to persevere in the immunocompromised host through modulating macrophage’s innate immune defenses. Conclusion: Pyocyanin inhibits macrophage functional defense responses to facilitate Pseudomonas aeruginosa infection.
Peningkatan Kemampuan Siswa dalam Mengembangkan Argumen Bernegosiasi melalui Pembuatan Dialog Film Pendek
Authors: Aminullah Ilhamuddin
Published: October 2021

Tujuan penelitian ini adalah untuk menguraikan upaya meningkatkan kemampuan siswa kelas X Mipa-2 SMAN 1 Mataram tahun pelajaran 2020/2021 dalam mengembangkan argumen teks negosiasi  melalui dialog film pendek.  Penelitian dilaksanakan dalam 2 siklus. Setiap siklus meliputi tahap (1) perencanaan, (2) tindakan, (3) observasi, dan (4) refleksi. Data dikumpulkan dengan metode observasi, tes, catatan lapangan, dan dokumenter. Data yang diperoleh melalui observasi dianalisis untuk melihat ketercapaian indikator tindakan, sedangkan data yang diperoleh melalui tes dianalisis untuk melihat ketercapaian indikator kompetensi mengembangkan argumen teks negosiasi. Analisis data dilakukan secara deskriptif. Hasil penelitian menunjukkan bahwa terjadi peningkatkan kemampuan mengembangkan argumen dalam teks negosiasi  siswa kelas X Mipa-2 SMAN 1 Mataram tahun pelajaran 2020/2021 melalui dialog film pendek. Hal terebut dibuktikan dengan adanya peningkatan nilai rata-rata siswa secara klasikal yaitu dari 75,05 pada prasiklus menjadi 78,86 (siklus I), dan 81,71 (siklus II), dan peningkatan ketuntasan belajar secara klasikal yaitu dari 57,14% pada prasiklus menjadi 74,29%  (siklus I), dan 88,57% (siklus II).
Influence of Sett Treatments on Biochemical, Weed, Physiological Parameters and Nutrient Uptake of Bajra Napier Hybrid Grass [CO (BN)5]
Authors:   Department of Agronomy, Tamil Nadu Agricultural University, Coimbatore-3, S V Varshini , C Jayanthi ,   Department of Agronomy, Tamil Nadu Agricultural University, Coimbatore-3
Published: October 2021

A field experiment was conducted at the Department of Agronomy, Tamil Nadu Agricultural University, Coimbatore, to study the influence of sett treatment on biochemical parameters, weed parameters, physiological parameters and nutrient uptake of bajra Napier hybrid grass. The results of the experiment indicated that on biochemical parameters, sett treatment with water (12 hours soaking fb 24 hours incubation) (S1) recorded higher reducing sugars (28.89 mg/g), total sugar (34.83 mg/g) and starch content (45.83 mg/g). Whereas the lower non reducing sugar content (5.94 mg/g) and total phenolics content (1.65 mg/g) were also observed with sett treatment with water (12 hours soaking fb 24 hours incubation) (S1). Similarly, on weed parameters, significantly lower weed density (9.90 No./m2) and weed dry weight (12.92 g/m2) was recorded with sett treatment with water (12 hours soaking fb 24 hours incubation) (S1). On physiological parameters, significantly higher leaf area index (28.98), relative water content (87.85 %) was registered with water (12 hours soaking fb24 hours incubation) (S1). Among sett treatments, water (12 hours soaking fb24 hours incubation) (S1) had registered higher nitrogen (192.8 kg ha-1), phosphorus (33.0 kg ha-1) and potassium (112.9 kg ha-1) uptake.
Antifeedant and Insecticidal Effect of Hexane Botanical Extracts on Diamondback moth (DBM), Plutella xylostella L.. (Lepidoptera: Plutellidae)
Authors:   Department of Agricultural Extension & Rural Sociology, Tamil Nadu Agricultural University, Coimbatore-641 003, S Susmitha , M Shanthi ,   Department of Agricultural Extension & Rural Sociology, Tamil Nadu Agricultural University, Coimbatore-641 003, M Murugan ,   Department of Agricultural Entomology, Tamil Nadu Agricultural University, Coimbatore 641003, Tamil Nadu, India, K Senthil ,   Department of Soils and Environment, Agricultural Entomology, Agricultural College & Research Institute, Tamil Nadu Agricultural University, Madurai 625104, Tamil Nadu, India, M L Mini ,   Department of Biotechnology, Centre of Innovation, Agricultural Entomology, Agricultural College & Research Institute, Tamil Nadu Agricultural University, Madurai 625104, Tamil Nadu, India
Published: October 2021

Diamondback moth (DBM), Plutella xylostella L. (Lepidoptera: Plutellidae) is one of the nefarious pests of cruciferous crops. Crude extracts from six botanicals obtained using hexane by continuous hot percolation process in Soxhlet apparatus were evaluated for their effect on larval mortality, antifeedant, growth and development of second instar larvae of DBM. The results revealed that the antifeedant index of Sesbania grandiflora 5% was 20.82% followed by Swietenia macrophylla 5%, which had 15.61%. The larval mortality and adult emergence exhibited by S. grandiflora was (66.67% and 33.33% respectively) after 72 h of feeding on treated leaf. It was statistically on par with S. macrophylla, which had 63.33% larval mortality and 36.67% adult emergence. With regard to the developmental period of life stages, no significant difference was observed among the treatments. However, all the treatments were significantly superior over untreated check in prolonging the developmental period of DBM. It was concluded that the S. grandiflora and S. macrophylla hexane leaf extract 5% are promising botanicals against P. xylostella, as they possess insecticidal, antifeedant and growth inhibitory activity. These results open up the scope for further isolation of bioactive compounds and validation under field conditions, which would lead to formulation development, ultimately it can be incorporated as ecofriendly component in the integrated pest management strategies.
Student Engagement and Factors Affecting Active Learning in English Language Teaching
Authors:   Universitas Ma Chung, Ginting Daniel
Published: October 2021

Learning is the process of how students take information and relate it to their prior knowledge into something meaningful. Learning promotes continuous growth and change in students. Student engagement is considered one of the significant predictors of successful learning. In general, student engagement refers to the active participation in a series of academic and co-curricular or school-related activities and commitment to pursuing learning goals. Does student engagement associated with successful learning occur in any settings, offline or online programs? This paper presents some theoretical frameworks about student engagement. This paper concludes with some pedagogical implications for English language teaching techniques.
STATE AND PROSPECTS OF THE DERIVATIVES WORLD MARKET DEVELOPMENT
Authors: Krasnova Marharyta
Published: October 2021

The purpose of the paper is to determine the current state of the global derivatives market in the context of structural and dynamic processes and to substantiate the prospects for its further development, given the existing global challenges. Methodology. The research is based on analysis and comparison of data from the Bank for International Settlements (BIS) for the period from 2000 to 2020. The paper uses methods of correlation analysis to establish the relationship between the state of the world economy and the size of the derivatives market. The method retrospective study of the dynamic series was applied to structure information of derivatives world market development. To reveal the features, the specifics of the usage of various mechanisms and tools for the distribution of derivatives, and established the differences between exchange and over-the-counter trading article applies elements of structural analysis. The results of the study showed the importance and scale of the global derivatives market for the global economy. They allowed us to reveal a close relationship between market size and world GDP and assess the structural features of the market. Accordingly, the derivatives market development has been periodized since 2000. Its structural features have been revealed in terms of the type of transactions, underlying asset, place, and currency of derivatives trading, their maturity, etc. Consequently, a significant predominance of OTC derivatives trading has been found, due to greater flexibility of instruments and less formalized control. The predominance of different types of derivative instruments in different segments of the market has been determined. Practical implications. The obtained conclusions are of interest in terms of monitoring the world derivatives market. They allow the correct assessment of the processes occurring in the market and respond to them rationally. The scientific confirmation of the connection between the size of the world economy and the market for derivative financial instruments is of particular practical importance. Systematization of market reform directions allows a better understanding of the ongoing processes in the over-the-counter derivatives market. Value/originality. The value of the article lies in the complexity of the analysis of the state and prospects of the derivatives world market development. It is provided through a detailed structural analysis, extrapolated to measures of market system transformation, as well as possible prospects for its further development.
AQUISIÇÃO DE LÍNGUA INGLESA E TECNOLOGIA: VANTAGENS E DESVANTAGENS DO USO DE INTERNET EM SALA DE AULA
Authors: Marschal Ramos Juliana , Gonçalves Werlang Luís André , Grégis Rosi Ana
Published: October 2021

A inclusão das novas tecnologias na aprendizagem de língua materna e de língua estrangeira tem sido apontada como uma ferramenta importante em sala de aula, seja como um auxílio para o professor ou como mediador na aprendizagem do aluno. Neste trabalho, o objetivo é entender se a internet exerce influência na aquisição de inglês como língua estrangeira. Com base em autores como Zhao (2005), percebe-se que os recursos tecnológicos permitem aos alunos um contato com a língua-alvo e seus aspectos culturais em situações reais. Para comprovar tais afirmações, a pesquisa foi aplicada com duas turmas de um projeto de extensão de uma universidade do Sul do Brasil, nas quais foram ministradas aulas com e sem recursos tecnológicos. Os dados coletados através de provas, uma inicial e outra final, foram corrigidos e sistematizados a fim de avaliar o aprendizado de inglês e comparar os resultados de ambas as turmas. Além disso, o andamento das aulas foi registrado em relatórios, para propor novas práticas, utilizando tecnologia, nas salas de aula de inglês. Através dos resultados, é possível depreender que, ao falarmos do uso de tecnologia, os fatores internos e externos podem influenciar nesse processo, e não apenas a internet. Motivação e o contexto social dos alunos fizeram diferença nos resultados da nossa pesquisa.
SABERES COMPARTILHADOS: A CONSTITUIÇÃO DE SUJEITOS NA CONSTRUÇÃO DE UM DICIONÁRIO DE LÍNGUA DE FRONTEIRA
Authors: Petri Verli , Alvares Jennifer
Published: October 2021

Resumo: Este artigo visa apresentar um gesto de leitura bem particular sobre os resultados obtidos no desenvolvimento de um projeto (que engendrou ensino/pesquisa/extensão) desenvolvido nas relações entre universidade e escola. Os resultados podem ser conferidos em uma obra publicada sob o título: Dicionário Compartilhado de Língua de Fronteira, que foi planejada e desenvolvida pela parceria feita entre o Programa de Educação Tutorial – Letras (PET) e o Programa de Escolas Interculturais de Fronteira (PEIF), financiados pelo MEC, sediados na Universidade Federal de Santa Maria, no período de 2014 e 2015, culminando com o lançamento das obras em 2016. O principal objetivo foi o de dar mais ou menos consciência aos sujeitos fronteiriços, na cidade de Itaqui – RS, sobre sua condição de falante que se realiza entre o português e o espanhol. O material produzido pelas crianças resultou em um dicionário que trata da língua compartilhada entre os sujeitos de fronteira de uma região sul-rio-grandense que faz divisa com a Argentina. A iniciativa deu-se com alunos do ensino fundamental das escolas de Itaqui-RS. Um trabalho feito por e para eles evidenciando essa “língua de fronteira” que muitas vezes é deixada às margens por uma parcela da população, bem como passa por invisível para a maioria das iniciativas governamentais.
O REFORÇO DA NEGAÇÃO NO FRANCÊS
Authors: DE SOUSA VICTOR HUGO RIBEIRO
Published: October 2021

Resumo: O presente trabalho é um estudo sincrônico e comparativo entre o francês e o português, que visa analisar de maneira empírica o comportamento da classe dos artigos na língua francesa e tem como foco as formas negativas dos artigos indefinidos e partitivos. Observando algumas sentenças negativas da língua francesa compostas por um marcador negativo e um quantificador negativo, percebeu-se que quando elas apresentam algum artigo indefinido ou partitivo, ocorre um outro tipo de reforço de negação: a negação duplicada, que se diferencia da dobrada[1]. Em razão disso, este trabalho se propõe analisar tal característica da língua francesa. Como essa característica já tinha sido percebida na língua portuguesa, a pesquisa se realiza através de algumas comparações entre duas línguas mencionadas.Palavras-chaves: negação do francês; dupla negação francesa; reforço de negação[1]     Termos próprios desta pesquisa utilizados para diferenciar dois tipos de estruturas negativas, que serão explicados no decorrer do trabalho.
“DELAÇÃO PREMIADA’’ - ENUNCIAÇÃO QUE ESTABILIZA O DIZER PUNITIVO NO BRASIL
Authors: Fátima Marly Ferreira de , Karim Taisir Mahmudo
Published: October 2021

Este trabalho tem por objetivo analisar o funcionamento da expressão delação premiada, que deslizam para colaboração premiada nos textos jornalísticos do jornal Folha de S. Paulo, publicações pela OAB nacional, fala publicada do juiz Sérgio Moro e decisões de ministro do STF, além de termos de acordos de delação premiada celebrados entre o Ministério Público Federal e o delator, consequentemente, gerando acordo da colaboração premiada, na investigação da Operação Lava Jato, assim, trabalharemos sob a ótica da perspectiva da semântica do acontecimento, em destaque a significação que a expressão delação premiada/colaboração premiada, estabelece no acontecimento que a faz funcionar.