bluuebunny/crossref_metadata_2025 huggingface dataset:
Differential Pricing and Emission Reduction in Remanufacturing Supply Chains with Dual-Sale Channels under CCT-Mechanism
Authors: Yuan Kaifu , Wu Guangqiang , Dong Hui , He Bo , Wang Dafei
Published: October 2020

In order to make optimal decisions for pricing and emission reduction, a remanufacturing supply chain system with dual-sale channels is investigated. With regard to the preferences of consumers for different channels and carbon cap-and-trade mechanisms, profit-maximization models are developed on supply chain members and systems in decentralized and centralized cases. Based on a backward induction, the corresponding formulae for decision variables are obtained. Then the effect of the industry emission control coefficient is analyzed and the optimal decisions of two cases are compared. Finally, the coordination mechanism and numerical analysis are presented. The result indicates that: (1) As the free carbon allowances granted by the government to the manufacturer increases, the investment in carbon reduction from the manufacturer will increase. As the industry emission control coefficient increases, the carbon emissions per product and the prices of new and remanufactured products will decrease, while the demands of the new and remanufactured products and the profits of supply chain members and systems will increase. (2) As the direct sale channel preference coefficient increases, the profits of the manufacturer and the system will increase while the retailer’s profit will decrease. Correspondingly, the carbon emissions of unit product will decrease, and the sales of the direct sale channel will increase while the sales of the retail channel will decrease. (3) The decision in the coordinated case not only ensures emission reduction and system profit to reach the level of the centralized case, but also raises the profits of supply chain members in the decentralized case. Therefore, it is preferable to other decisions. (4) As the carbon trading price increases, the emission reduction investment from the manufacturer will increase while the profits of the supply chain and its members will increase.
Risk Analysis and Control Factors Based on Excavation of a Large Underground Subway Station under Construction
Authors: Zhang Zhien , Huang Mingli , Wu Baohua
Published: October 2020

Considering the convenience of pedestrian transfer, reasonable structural stress and beautiful shape design, most subway stations adopt symmetrical design. At present, the new subway station is developing in the direction of a multidimensional space, as well as a large scale, and complex structure. Tunnel construction also presents unpredictability, coupling amplification and high risks. For example, a subway extension project involves construction, which would affect the normal use of the subway or damage its structure. Based on excavation of the largest underground subway station under construction in China, the Erligou station extension project (line 16 of Beijing Metro), and using theoretical analysis, numerical simulation, monitoring data, and other research methods, this paper quantitatively analyzes the risk of a large space station’s construction process on the adjacent existing station structure and track, as well as highlights key, high-risk sub-projects, or construction steps, combined with specific engineering measures to ensure safety during construction of a new station. The general rules concerning large space subway station construction are further summarized to provide reference for similar projects.
Immunotherapy with Checkpoint Inhibitors for Hepatocellular Carcinoma: Where Are We Now?
Authors: Tovoli Francesco , De Lorenzo Stefania , Trevisani Franco
Published: October 2020

Immune checkpoint inhibitors (ICIs) are beginning to show promise in the clinical management of hepatocellular carcinoma (HCC). Most recently, the anti-programmed death protein-1 (PD-1) agent atezolizumab combined with bevacizumab demonstrated superiority to sorafenib in a Phase 3 randomised clinical trial in the frontline setting. Other ongoing trials of immunotherapy for HCC are exploring different drug combinations, such as a double checkpoint blockade with PD-1 and anti-Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) agents or with tyrosine kinase inhibitors. Moreover, ICIs are being tested in the adjuvant and neoadjuvant settings trying to resolve long-time unmet needs in HCC. The results of the ongoing trials will be critical to understanding the extent of the therapeutic role of ICIs in the complex and multifaceted clinical scenario of HCC. Still, there are some critical points which need further attention to clarify the best use of ICIs in HCC patients. For instance, the actual eligibility rate of patients in the real-life scenario, the prompt identification and correct management of immune-mediated adverse events, the identification of biomarkers predicting response or resistance, and strategies to prevent the tumour escape from ICI effect.
Evaluation of Regional Climate Models (RCMs) Performance in Simulating Seasonal Precipitation over Mountainous Central Pindus (Greece)
Authors: Stefanidis Stefanos , Dafis Stavros , Stathis Dimitrios
Published: October 2020

During the last few years, there is a growing concern about climate change and its negative effects on water availability. This study aims to evaluate the performance of regional climate models (RCMs) in simulating seasonal precipitation over the mountainous range of Central Pindus (Greece). To this end, observed precipitation data from ground-based rain gauge stations were compared with RCMs grid point’s simulations for the baseline period 1974–2000. Statistical indexes such as root mean square error (RMSE), mean absolute error (MAE), Pearson correlation coefficient, and standard deviation (SD) were used in order to evaluate the model’s performance. The results demonstrated that RCMs fail to represent the temporal variability of precipitation time series with exception of REMO. Although, concerning the model’s prediction accuracy, it was found that better performance was achieved by the RegCM3 model in the study area. In addition, regarding a future projection (2074–2100), it was highlighted that precipitation will significantly decrease by the end of the 21st century, especially in spring (−30%). Therefore, adaption of mountainous catchment management to climate change is crucial to avoid water scarcity.
Characteristics, Outcomes and 60-Day Hospital Mortality of ICU Patients with COVID-19 and Acute Kidney Injury
Authors: Thakkar Jyotsana , Chand Sudham , Aboodi Michael S. , Gone Anirudh R. , Alahiri Emad , Schecter David E. , Grand David , Sharma Deep , Abramowitz Matthew K. , Ross Michael J. , Dicpinigaitis Peter , Kapoor Sumit
Published: October 2020

Background

AKI has been reported in patients with COVID-19 pneumonia and it is associated with higher mortality. The aim of our study is to describe characteristics, outcomes, and 60-day hospital mortality of patients with COVID-19 pneumonia and AKI in the intensive care unit (ICU).

Methods

We conducted a retrospective study in which all adult patients with confirmed COVID-19 who were admitted to ICUs of Montefiore Medical Center and developing AKI were included. The study period ranged from March 10 to April 11, 2020. The 60-day follow-up data through June 11, 2020 were obtained.

Results

Of 300 adults admitted to the ICUs with COVID-19 pneumonia, 224 patients (75%) presented with AKI or developed AKI subsequent to admission. A total of 218 (97%) patients required invasive mechanical ventilation for moderate to severe acute respiratory distress syndrome (ARDS). A total of 113 (50%) patients had AKI on day 1 of ICU admission. The peak AKI stages observed were stage 1 in 49 (22%), stage 2 in 35 (16%), and stage 3 in 140 (63%) patients, respectively. Among patients with AKI, 114 patients (51%) required RRT. The mortality rate of patients requiring RRT was 70%. Of the 34 patients who were survivors, 25 (74%) were able to be weaned off RRT completely before hospital discharge. Nonsurvivors were older and had significantly higher admission and peak creatinine levels, admission hemoglobin, and peak phosphate levels compared with survivors. The 60-day hospital mortality was 67%.

Conclusions

COVID-19 requiring ICU admission is associated with high incidence of severe AKI, necessitating RRT in approximately half of such patients. The majority of patients with COVID-19 and AKI in ICU developed moderate to severe ARDS, requiring invasive mechanical ventilation. Timing or severity of AKI did not affect outcomes. The 60-day hospital mortality is high (67%). Patients with AKI requiring RRT have high mortality, but survivors have good rates of RRT recovery.

Podcast

This article contains a podcast at https://www.asn-online.org/media/podcast/K360/2020_12_31_KID0004282020.mp3
Nadir Karaciğer Metastaz Nedeni; Nöroendokrin Tümör (Bir olgu Nedeniyle)
Authors: BURAN Tahir , KASAP Elmas , GÖKSEL Gamze , ALMACAN Burcu
Published: October 2020

Nöroendokrin tümörler, nöroendokrin sistem hücrelerinden köken alan heterojen bir neoplazma grubundan oluşmaktadırlar. Bu olgu sunumunda diffüz karaciğer metastazı ile seyreden non-fonksiyone bir nöroendokrin tümör olgusu tartışılmıştır. Kliniğimize karın ağrısı ve karında şişlik şikayetleri ile başvuran 61 yaşındaki erkek hastanın yapılan radyolojik incelelemelerde karaciğerde diffüz metastazla uyumlu çok sayıda hipodens kitle lezyonları saptandı. Yapılan karaciğer biyopsisi, hepatik nöroendokrin tümör metastazı ile uyumlu bulundu. Diffüz karaciğer tutulumu birlikte hastanın yaşının ileri olması nedeni ile cerrahi rezeksiyon düşünülmedi. Hastaya uzun etkili somatostatin analoğu başlandı. Takiplerde hastanın semptomları geriledi

Sonuç olarak nadir görülen nöroendokrin tümörleri yavaş seyrinin aksine tümüyle yakın zaman kadar asemptomatik seyretmesine karşın, yaygın karaciğer metastazıyla birlikte afonksiyone olarak prezente olabileceği göz önünde bulundurulmalıdır.
LİDER-ÜYE ETKİLEŞİMİNİN ÖRGÜTSEL VATANDAŞLIK DAVRANIŞI ÜZERİNE ETKİSİNDE ALGILANAN ÖRGÜTSEL DESTEĞİN ARACILIK ROLÜ: BİR ZİNCİR PERAKENDE İŞLETMESİ ÜZERİNE ARAŞTIRMA
Authors: ATAKAY Özlem , YILMAZ Sefer
Published: October 2020

Rekabet koşullarının arttığı günümüzde örgütler
rakipleri tarafından taklit edilmesi güç olan
örgüt içi yapılarına yönelmişlerdir. Bu noktada, liderin çalışanları ile olan
etkileşimi,  örgüt içerisinde çalışanlar
tarafından algılanan örgütsel destek ve örgüt başarımına etki eden örgütsel
vatandaşlık davranışı gibi unsurlar oldukça önem arz etmektedir. Bu çalışmanın
amacı; lider - üye etkileşimi, algılanan örgütsel destek ile örgütsel
vatandaşlık davranışları arasındaki ilişkileri belirlemek ve lider - üye
etkileşiminin örgütsel vatandaşlık davranışı üzerine etkisinde algılanan
örgütsel desteğin aracılık etkisini ortaya koymaktır. Araştırma kapsamında
Adana ve Mersin illerinde mağazaları bulunan yerel bir zincir perakende
işletmesinde çalışan toplam 500 katılımcıya anketler dağıtılmıştır.
Araştırmadan elde edilen verilere göre; lider - üye etkileşimi ile örgütsel
vatandaşlık davranışı arasında pozitif anlamlı bir ilişki, lider - üye
etkileşimi ile algılanan örgütsel destek arasında pozitif anlamlı bir ilişki,
algılanan örgütsel destek ile örgütsel vatandaşlık davranışı arasında pozitif
anlamlı bir ilişki olduğu tespit edilmiştir. Ayrıca lider - üye etkileşiminin
örgütsel vatandaşlık davranışı üzerine etkisinde algılanan örgütsel desteğin
aracılık etkisinin olduğu ortaya konmuştur.
Condiciones laborales del sector turismo en Argentina: el rol de la educación y la especialización turística
Authors:   , García Carolina Inés
Published: October 2020

Esta tesis analiza el mercado laboral y los retornos a la educación del turismo en Argentina para el periodo 2007-2017. Se utilizan regresiones de Mincer con la corrección de Heckman y se añaden controles por características del individuo y del puesto de trabajo. Los datos utilizados corresponden a la Encuesta Permanente de Hogares del Instituto Nacional de Estadísticas y Censos de Argentina. Se encuentra que los retornos a la educación son mayores en el sector turismo comparado con el resto de los servicios y el resto de la economía, aun incluyendo controles regionales. En el turismo, las diferencias en los retornos entre géneros no resultan estadísticamente significativas. Incorporando la especialización turística, trabajar en regiones especializadas genera una prima salarial para las mujeres del sector turismo. La interacción entre esta especialización con los niveles educativos, sin embargo, implica un efecto de amortiguación en los retornos de estas trabajadoras.
Somaclonal variation of grape plants regenerated from colchicinated cells of suspension cultures
Authors: Зленко Валерий Анатольевич , Клименко Виктор Павлович , Павлова Ирина Александровна , Лущай Екатерина Александровна , Петухова Анастасия Викторовна , Абдурашитова Анифе Смаиловна , Лиховской Владимир Владимирович , Егорова Н.А.
Published: October 2020

Экспланты листьев, черешков листьев и междоузлий сортов винограда Бианка, Подарок Магарача, Interlaken seedless, Рута, Сфинкс и гибридной формы Е-342 были взяты из зеленых побегов, выросших на выведенной из состояния покоя вызревшей лозе, и высажены в культуру in vitro , в жидкую среду NN с добавкой 2,4-D и BАP (по 1 мг/л). Как для получения проэмбриогенных каллусов и клеточных суспензий, так и развития из них соматических эмбриоидов и регенерации растений, в зависимости от генотипической специфичности и этапов, использовали различные базовые среды (NN, MS и PG), регуляторы роста (2,4-D, BАP, IAA, NOA и GА) и биологически активные вещества (FА, PVP и гумат Na). Клеточные суспензии обрабатывали раствором 0,02% колхицина, 0,02 и 1% DMSO; 0,5 и 1мг/л BАP; 20 г/л сахарозы с добавкой или без среды NN (концентрации в общем растворе с суспензией клеток) в течение 1 и 2 сут. при +27-30°C. Адаптированные из in vitro к условиям in vivo и выросшие в условиях открытого грунта растения-сомаклоны сортов Сфинкс, Рута и гибридной формы Е-342 различаются (сомаклональная изменчивость) по приросту и вызреванию лозы в конце вегетации.

Explants of leaves, petioles and internodes of grape varieties ‘Bianca’, ‘Podarok Magaracha’, ‘Interlaken Seedless’, ‘Ruta’, ‘Sphinx’ and hybrid form E-342 were taken from green shoots grown on a ripened vine removed from dormancy and planted in vitro, in the liquid NN medium with 2,4-D and BAP (by 1 mg/l each) added. Various basic media (NN, MS and PG), growth regulators (2,4-D, BAP, IAA, NOA and GA3) and biologically active substances (FA, PVP and Na humate) were used to obtain proembryogenic calli and cell suspensions and to develop somatic embryoids and plant regeneration, depending on genotypic specificity and stages. Cell suspensions were treated with a solution of 0.02% colchicine, 0.02 and 1% DMSO, 0.5 and 1 mg/l BAP, 20 g/l sucrose with or without NN medium (concentration in a total solution with cell suspension) for 1 and 2 days at + 27-30 ° C. Adapted from in vitro to the in vivo conditions and grown in open ground, somaclone plants of ‘Sphinx’, ‘Ruta’ varieties and hybrid form E-342 differ (somaclonal variation) in increment and maturation of the vine at the end of the growing season.
Meningkatkan Keaktifan dan Hasil Belajar Siswa dalam Pembelajaran Matriks Menggunakan Biji Tasbih Gemerincing
Authors: Setiadi Iwan
Published: October 2020

Penelitian ini bertujuan untuk meningkatkan keaktifan dan hasil belajar siswa pada mata pelajaran Matematika, materi pokok Matriks melalui model pembelajaran kooperatif Biji Tasbih Gemerincing, siswa kelas XI MIA, MA Al Wathoniyah 43 Jakarta, semester ganjil tahun pelajaran 2019/2020. Subjek penelitian tindakan kelas ini adalah seluruh siswa kelas XI MIA, berjumlah 20 orang siswa. Penelitian ini dilaksanakan dalam dua siklus, setiap siklus terdiri dari tiga kali pertemuan.  Prosedur penelitian meliputi: perencanaan, pelaksanaan, observasi, dan refleksi.  Hasil penelitian menunjukkan bahwa terdapat peningkatan keaktifan belajar dan hasil belajar siswa pada mata pelajaran Matematika, materi pokok Matriks melalui model pembelajaran kooperatif Biji Tasbih Gemerincing, siswa kelas XI MIA, MA Al Wathoniyah 43 Jakarta, semester ganjil tahun pelajaran 2019/2020.
Outdoor Learning for Cadets of Maritime Higher Education Institute: The Students' Perspective
Authors: Batu Purnama Nancy Lumban , Wida Cahyaningrum
Published: October 2020

This paper aims to describe how motivation, attitude, input, and exposure affect learners anxiety in students uptake in acquiring English. The participants of this study are adult learners who have learned English averagely for more than ten years. Studies on SLA have illustrated that learners' anxiety could hinder them from acquiring a second or a foreign language. As an effort to reduce the tension and anxiety, a set of out-of-classroom learning activities was conducted. It was then observed how the students gradually loosened their anxiety and gained more confidence in expressing themselves in English throughout the activities
A Analisis Tingkat Kecemasan Matematika Siswa SMA/Sederajat Berdasarkan Gender
Authors: Mega Putri
Published: October 2020

Penelitian ini adalah penelitian deskriptif kuantitatif yang bertujuan untuk mendeskripsikan tingkat kecemasan matematika siswa SMA berdasarkan gender dan indikator terbaik kecemasan matematika dalam pembelajaran matematika. Responden dari penelitian ini adalah siswa SMA/Sederajat kelas 1, 2, dan 3 sebanyak 150 siswa perempuan dan 66 siswa laki-laki. Kuisioner dianalisis dengan menggunakan uji Mann Whitney. Hasil penelitian ini menunjukkan bahwa tingkat kecemasan siswa cenderung rendah, hanya 10% siswa yang memiliki tingkat kecemasan yang tinggi dimana 3% siswa laki-laki dan 7% siswa perempuan. Siswa perempuan memiliki tingkat kecemasan matematika yang lebih tinggi dari pada siswa laki-laki. Tetapi tidak ditemukan adanya perbedaan yang signifikan antara keduanya. Terdapat 3 indikator dengan kecemasan matematika tertinggi untuk siswa laki-laki maupun siswa perempuan yaitu ketika siswa menghadapi ujian dadakan dan indikator dengan kecemasan matematika terendah adalah saat belajar di tempat les. Hasil penelitian ini direkomendasikan sebagai salah satu bahan pertimbangan untuk merancang strategi pembelajaran pada siswa SMA/Sederajat.
Kinerja Wasit Bola Voli Indoor Ditinjau Dari Perbedaan Gender
Authors: Debi Krisna Irawan  , Chairul Umam Ramadhan  , Rafdlal Saeful Bakhri  , Moch. Latif
Published: October 2020

Kinerja seorang wasit pada sebuah pertandingan olahraga sangatlah penting karena unsur terselenggaranya sebuah pertandingan olahraga selain adanya kedua tim yang bertanding tentu harus ada pula seseorang yang menjadi penengah diantara kedua tim tersebut dan dianggap tidak memihak kepada salah satu tim. Selain itu, seiring dengan perkembangan masing-masing cabang olahraga juga harus dibarengi dengan perkembangan sumber daya manusia baik yang berperan sebagai atlet maupun yang berperan sebagai wasit. Aspek gender juga menjadi salah satu penentu, dimana sangat jarang ditemukan seorang wasit perempuan. Hal inilah yang menjadi ketertarikan penulis sekaligus sebagai tujuan awal dari penelitian ini yaitu mengetahui kinerja mana yang lebih baik antara wasit laki-laki bila dibandingkan dengan wasit perempuan saat memimpin pertandingan. Metode yang digunakan pada penelitian ini ialah metode deskriptif komparatif dimana data penelitian akan diambil dari sampel sejumlah 30 orang (20 orang wasit laki-laki, dan 10 orang wasit perempuan) yang berdomisili di Pengcab PBVSI Kabupaten Sukabumi. Hasil penelitian menunjukkan bahwa kinerja wasit laki-laki dinilai lebih baik daripada wasit perempuan yang dinyatakan dalam uji statistik menggunakan Independent Sample T-Test dengan nilai signifikansi sebesar 0,000 (lebih kecil dari 0,05). Atas dasar hasil penelitian tersebut maka dapat ditarik kesimpulan bahwa Terdapat perbedaan antara Kinerja Wasit Laki-Laki lebih dengan Wasit Perempuan saat memimpin sebuah pertandingan, dimana Kinerja Wasit Laki-Laki dinilai lebih baik disbanding dengan Wasit Perempuan saat memimpin pertandingan Bola Voli Indoor.
Spatio-temporal analysis of innovations diffusion in the agriculture
Authors: Teslenok Kirill , Teslenok Sergey
Published: October 2020

The article presents the results of the analysis of the spatio-temporal variability of the processes of diffusion of innovations in the agricultural sector of the Russian Federation by subjects.

The application of a group of traditional and mathematical methods in the research process is complemented by the widespread use of the capabilities of geoinformation technologies and, first of all, geoinformation-cartographic modeling.

In the process of conducting research, the corresponding specialized GIS databases “Innovations in the Subjects of the Russian Federation” were designed and practically implemented in various software versions. Based on them, the construction and analysis of a complex of geographic information-cartographic models, differing in the degree of complexity, reflecting the innovative processes occurring in agriculture of all regions of the Russian Federation, was performed.

Each of the series of obtained analytical base and resulting maps illustrates various aspects of the innovative development of agriculture and the diffusion of innovations at different time periods. The results of geographic information mapping and modeling were also presented in the form of animated maps and cartographic animations reflecting the features of the territorial distribution of innovations and the spatio-temporal dynamics of their diffusion.

Spatio-temporal geographic information-cartographic analysis of the diffusion of innovations made it possible to identify some objective laws of this process. First of all, there was a marked movement of innovations in the agriculture of the Russian Federation in the space-time continuum in the direction from innovative nuclei and sub-nuclei to innovative sub-periphery and periphery, and from donor regions of agricultural innovations to recipient regions.

Geographically, the diffusion of innovations in agriculture of the Russian Federation occurs mainly in the direction from the largest cities (at the same time being leading scientific and technical centers) and areas of intensive agriculture (primarily farming) to the regions of the east and north of the European part, Siberia and the Far East.

The wide use of the capabilities of geographical information systems and geographic information technologies at all stages of the study allowed the formation of cartographic and attributive databases of the GIS “Innovations in the Subjects of the Russian Federation” according to the main indicators of the innovative development of the agricultural industry at the territorial level of the constituent entities of the Russian Federation. On their basis, a significant number of maps and geoinformation-cartographic models of territorial innovative agricultural systems of regional level, the processes of diffusion of innovations occurring in them were constructed and analyzed, and their main spatio-temporal patterns were revealed.
Methodology to identify robots given the type of control designation
Authors: Arkhipenka S. A. , Shilin L. U. , Naurotsky A. A. , Kuznetsov A. P.
Published: October 2020

Currently, robot manufacturers usually use closed proprietary protocols, which significantly complicates the development and integration of new robots and complexes. We propose to use a standard sequence of requests and responses between the control server and the client (some steps may be skipped). The first and second steps are designed to check the availability of equipment when you first turn on the system or during connection setup. If the verification is successful, the сontrol server proceeds to the next step. The third and fourth steps stand for initial configuration and adjustment of remote control. In the fifth step, the digital control signal is transmitted from the control server to the robot. The signal transmits all the necessary information to control the robot device. The keys are string fields (up to 256 characters). At the sixth step, the control server receives a сontrol response - the structure of the data transmitted from the client (robot) to confirm data acceptance and return of additional parameters. To identify robots, we propose to classify them by type and designation and indicate available types of control. For a detailed description of the robot, the entire initialization scheme is used. The proposed methodology is intended to describe infrastructure and platform independent interaction, which allows it to be used in various types of robotic systems.
Аdaptive broadband low-noise RF amplifier
Authors: Malevich I. Yu. , Zayats P. V.
Published: October 2020

Adaptive broadband low-noise radio frequency amplifiers (ABLNRFA) are widely used in the construction of systems for protecting radio receiving paths from nonlinear damage in a non-stationary electromagnetic environment (EME). One of the promising focus areas on the creation of ABLNRFA is the development of devices in the class of circuits with switched networks. The creation of such devices has certain features, since, along with the need to ensure a low noise figure and digital control of the regulation characteristic, it is required to provide high linearity and a large dynamic range (DR) of the device. This paper presents the results of the logical-heuristic synthesis of ABLNRFA with an adaptively adjustable transducer gain, which changes due to switching of transformer feedback circuits. In order to check the functional and technical characteristics of the synthesized ABLNRFA and optimize its parameters, a model was developed and studied in the ADS environment. The proposed ABLNRFA technical solution provides a discrete (23, 14, 10 and 5 dB) wideband change in the transmission coefficient, while the DR for third-order intermodulation in terms of a 1 MHz band is 83, 92, 98 and 104 dB, respectively. A step change in the transducer gain in the circuit of the lossless feedback circuit developed by ABLNRFA avoids the accumulation of additional noise in the structure and provides a low-noise figure that does not exceed 1 dB. The technical characteristics of ABLNRFA allow one to adaptively increase the overload capacity of the radio receiving path with a proportional expansion of its DR in the conditions of non-stationary EME, and thus increase the efficiency of the level protection system against nonlinear damage to the receiving paths of radio communication, radar and radio navigation.
Justification of binder material selection for carbon particles incorporation into fibrous electromagnetic radiation absorber
Authors: Belousova E. S. , Dumchev B. I. , Al-Mahdawi M. S.Kh.
Published: October 2020

The paper presents justification of a binder material for incorporating carbon particles into the interfiber space of electromagnetic radiation absorber. A method for carbon particles incorporation into a fibrous material has been developed. It is based on applying a carbon-containing nanocomposite to the fibrous material’s surface. Previously, the research of carbon particles incorporation into a synthetic material by using an aqueous solution were carried out, which ensured a uniform distribution of carbon particles in the material structure. However, the properties of the material have changed significantly upon mechanical deformation. Therefore, the carbon particles incorporation process was investigated using various nanocomposites obtained on the basis of mixtures of vinyl acetate polymer, or epoxy polymer, or surface-active substance with carbon black. Based on the results of electron microscopic analysis and the reflection and transmission coefficients frequency dependences in the frequency range 0.7–17 GHz, the efficiency of using a nanocomposite based on a mixture of surface-active substance and carbon black to create electromagnetic radiation absorbers was justified. Such electromagnetic radiation absorbers have the transmission coefficient value about –18 dB and reflection coefficient value about –12 dB in the frequency range 7–13 GHz. Carbon-containing electromagnetic radiation absorbers based on fibrous material have thickness less than 3 mm, properties of flexibility and resistance to mechanical deformation. It can be used in various fields, in particular for hiding objects from radio frequency reconnaissance or protecting equipment from external interference.
INFILTRATIVE LUNG TUBERCULOSIS, PEPTIC ULCER DISEASE AND HIV INFECTION (COMORBIDITY AND MULTIMORBIDITY OF DISEASES)
Authors: Davydkin IL L , Osadchuk AM M , Borodulina EA A , Gritsenko TA A
Published: October 2020

Aim - to explore the features of comorbidity and multimorbidity of infiltrative pulmonary tuberculosis (IPT), peptic ulcer (PU), HIV infection in modern conditions. Materials and methods. The study involved 392 patients with IPT aged 20-44 years, HIV-positive with CD4 200500/pl, suffering from uncomplicated ulcer. Results. Peptic ulcer disease was diagnosed in 20.5% of patients with IPT and 19.5% patients with HIV infection in stage C2 and IPT, complaining of dyspepsia. The multimorbid combination of IPT, HIV infection and PU is characterized by: oligosymptomatic onset of tuberculosis; the clinical picture shows the dominance of asthenic syndrome, manifestations of gastric and intestinal dyspepsia, weight loss (2-4 times more frequently than in patients without HIV infection), less prominent destructive process in the lung tissue (2 times less than in patients without HIV infection). H.pylori is the aetiological factor of PU in 62.5% of patients with IPT and 58.7% patients with HIV infection in stage C2 and IPT. The combination of H.pylori-negative PU and IPT has significantly more unfavorable prognosis compared to comorbidity of H.pylori-positive peptic ulcer and IPT. Conclusion. Diagnosis of PU, HIV infection and H.pylori-status allows defining multiple categories of comorbidity (patients with IPT and dyspeptic syndrome, patients with IPT and H.pylori-associated peptic ulcer, patients with IPT and H.pylori-negative ulcer) and multimorbidity (HIV-infected patients with IPT and H.pylori-associated ulcer, HIV-infected patients with IPT and H.pylori-negative ulcer).
INNOVATION IN SSMU: INFRASTRUCTURE, TRAINING, DEVELOPMENT OF BREAKTHROUGH PROJECTS, TRANSFER OF TECHNOLOGIES INTO PRACTICE, PUBLIC PARTICIPATION IN RUSSIAN AND REGIONAL INNOVATION ECOSYSTEM
Authors: Kotelnikov GP P , Kolsanov AV V
Published: October 2020

The article focuses on the role of Samara State Medical University in the development of innovative capacity of the Samara region in the sphere of healthcare and medical education. Special attention is given to the multilevel innovative infrastructure of SSMU, which includes such unique departments as the Center for groundbreaking research “IT in medicine”, the scientific and production technology park, scientific-educational centers, small innovative enterprises and others. In particular, this infrastructure is an integrative platform not only for own innovation process at the university, but also for the development of current medical science prospects, for the formation of unique competences in interdisciplinary spheres, for the realization of science-based business, for the organization of innovative educational process (especially in the sphere of simulation technologies), for implementation into clinical practice, and also for successful incorporation into international cooperation.
COMPLEX TREATMENT OF PATIENTS WITH OSTEOARTHRITIS OF THE TEMPOROMANDIBULAR JOINT
Authors: Potapov VP P , Maltceva AV V , Potapov IV V , Ponomarev AV V , Kameneva LA A
Published: October 2020

This article describes the methods of treatment of patients with osteoarthritis of the temporomandibular joint (TMJ OA) on the example of the study of 63 patients. Aim - development of an algorithm for complex treatment of patients with OA of the TMJ. Materials and methods. All patients were examined by the scheme, which included a survey, inspection, making diagnostic models, checking occlusal contacts, recording mandibular movement, electromyographic study of masticatory muscles, and CT scan of the TMJ. Results. All patients were divided into 3 groups. The treatment of patients of the first subgroup included selective polishing of the teeth, the use of non-narcotic analgesics, nonsteroidal anti-inflammatory preparations and physiotherapy The patients of the second subgroup received medical-diagnostic mouthguards, and the third subgroup of patients was treated by successive disocclusion of the teeth in combination with massage, physiotherapy and myogymnastics. Conclusions. Treatment of OA of the TMJ should be comprehensive and include orthopedic treatment, the use of drugs, physical therapy, massage and myogymnastics.
DEVELOPMENT OF EYE-TRACKING BASED SYSTEMS FOR ALTERNATIVE AND AUGMENTATIVE COMMUNICATION
Authors: Balovnev D A , Znayko G G
Published: October 2020

Rehabilitation of people with communication impairments is a socially important issue in Russia. Currently, there are no high-tech alternative and augmentative communication devices on the Russian market. On creation of such devices, a need arises for a model which structures any occurring communication impairment. The article sets out the structure of an alternative model of speech production developed on the basis of Levelt’s model of speech production. Practical application of the developed model is shown in the course of designing a high-tech platform for alternative and augmentative communication.
IMPLEMENTATION OF TQM PRINCIPLES IN THE SYSTEM OF INTERNAL QUALITY AND SAFETY CONTROL OF MEDICAL PRACTICE ON THE EXAMPLE OF SAMARA REGIONAL CLINICAL ONCOLOGY DISPENSARY
Authors: Orlov A E , Pavlov V V , Proshina O A
Published: October 2020

Introduction. The article presents an example of implementation of the principles of total quality management (TMQ) in the system of internal quality and safety control of medical practice in a large medical organization. Results. The dispensary has established a unified quality service that unites all the structures of the clinic involved in the implementation of internal control and interaction with the subjects of external control, thus becoming a coordination center. Summary. The service functions include complex tasks, previously attributed to the functions of various divisions of the institution.
THE DEVELOPMENT OF THE COMBINED MEDICINAL HERBAL REMEDIES FOR STOMATOLOGICAL AND OTORHINOLARYNGOLOGICAL PRACTICE
Authors: Kurkin V A , Varina N R , Avdeeva E V , Klimova L D , Pervushkin S V , Ryazanova T K
Published: October 2020

Aim - to develop a series of combined medicinal herbal remedies «Dentos» for dental and otorhinolaryngological practice, in which complex effect on different elements of the infectious inflammatory process is achieved by the combination of several groups of biologically active compounds. Materials and methods. Basic phytocomposition is a medicinal preparation "Dentos", which is composite alcohol-water extract on 70% ethanol from the five types of medicinal plant raw materials: the leaves of Eucalyptus viminalis, the herb of Echinacea purpurea, the flowers of Calendula officinalis, the bark of Quercus robur and the oil of Caryophyllus aromaticus. Dosage forms based on it are the following: dental gel, medicinal lozenges, therapeutic and prophylactic toothpaste. The experimental research involved the methods of marketing analysis, various technological methods (extraction methods of developing medicinal preparations and instrumental definition of technological parameters), and modern methods of pharmaceutical analysis: chromatographic methods (TLC), UV-spectroscopy, HPLC, chemical methods (qualitative test-tube reaction). Results. The blend composition of the developed medicinal preparations was proposed (dental gel, medicinal lozenges, therapeutic and prophylactic toothpaste), the technology of their production was elaborated, the quality parameters were studied and the approaches to standardization of remedies were substantiated.
EXTERNAL RADIO-FREQUENCY DENERVATION OF RENAL ARTERIES
Authors: Petrov E S , Volobuev A N , Khokhlunov M S , Mazilov M M
Published: October 2020

Aim - study of renal arteries denervation for the surgical treatment of primary arterial hypertension. Materials and methods. Radio-frequency ablation from the side of artery adventitia was carried out on preparations of the renal arteries. Results. The study determined comprehensible regimes of radio-frequency ablation, not resulting in a large degradation of the renal arteries strength properties, but providing reliable denervation of these arteries. Micro-photos of the renal artery wall after carrying out radio-frequency ablation were obtained. Conclusion. It is shown that the most comprehensible way of the renal arteries denervation is radio-frequency ablation from the side of artery adventitia.
UNIVERSAL APPROACH TO THE PREVENTION OF THE SYNDROME OF PATHOLOGICAL PREGNANCY
Authors: Lipatov IS S , Tezikov YuV V , Martynova NV V , Mingalieva LK K , Gogel LYu Yu , Belokoneva TS S , Kalinkina OB B , Zhernakova EV V , Yusupova RR R
Published: October 2020

Aim - the purpose of the study is the development of a method for prevention of pathological pregnancy syndrome from the perspective of integral genesis, determined by morphological and functional abnormalities in the fetoplacental system, assessing the effectiveness of methodological standards of evidence-based medicine. Materials and methods. Prospective study of 435 women with high risk of decompensation of placental insufficiency was conducted. Depending on the method of prevention of gestational complications 4 groups were formed: 1st group included 145 pregnant women, who were prescribed dydrogesterone on the 6-20 weeks of gestation, and starting with the 21st week - highly-purified diosmin 600 mg as vasoprotective; in the 2nd group 118 women received a course of preventive treatment with low doses of acetylsalicylic acid; 3rd group included 102 patients who underwent a course of preventive monotherapy with magnesium; 4th group comprised 70 pregnant women who refused preventive treatment. A control group encompassed 30 healthy pregnant women. Dynamic survey included definition of markers of endothelial and hemostasiological dysfunction, vascular-platelet dysfunction elements, apoptosis, inflammatory response, total reactive capacity of the organism, magnesium and carbon dioxide concentrations; a hystostereometric study of placenta was conducted. Standards of evidence-based medicine were applied for the objectification of the effectiveness of the developed method. Results. Method of preventing great obstetric syndromes by successive appointment of progestogen dydrogesterone on the early stage of pregnancy followed by vasoprotective diosmin 600 mg in the 2nd half of pregnancy showed high efficiency (NNT 1.4 (95% CI 1.1 -1.7); OSH 5.3 (95% CI 4.7 -5.8), namely reducing pre-eclampsia by 93%, placental insufficiency with intrauterine growth restriction and/or chronic fetal hypoxia - 95%, preterm birth - 86%, and no premature abruption of normally situated placenta, severe forms of pre-eclampsia and placental insufficiency. Higher clinical effectiveness of the proposed method of prophylaxis of pathological pregnancy syndrome, compared to the use of low-dose acetylsalicylic acid and preparation of magnesium, can be explained by the normalizing effect of dydrogesterone and highly-purified diosmin 600 mg on the immune and biochemical homeostasis, apoptosis and angiogenesis, activation of endothelial and hemostasiological system, adaptive compensatory reactions in the placenta. Conclusion. The method of choice for the prevention of pathological pregnancy syndrome at high risk of fetoplacental system decompensation is the application of progestogen dydrogesterone and vasoprotective diosmin according to the developed method. The study revealed the potential of targeted selection of preventive methods depending on special needs of pregnant women.
REFRACTORY FORM OF GASTROESOPHAGEAL REFLUX DISEASE: EVOLUTION OF CONCEPTS
Authors: Davydkin IL L , Osadchuk AM M , Gritsenko TA A , Kurtov IV V
Published: October 2020

Aim of the review - to illuminate the problem of proton pump inhibitor(PPI)-refractory form of gastroesophageal reflux disease (RFGERD) at a modern scientific level. It is shown that PPI remain the standard and the most effective therapy for GERD. Patients, whose GERD symptoms are refractory to PPI, should be further examined to exclude other diseases. It is possible to use different treatment options: medication, endoscopic or surgical treatment. The response to IPP therapy can be complete (no symptoms), partial or absent. In patients with complete response to treatment with PPI no other therapy is provided. Currently, new methods of RFGERD treatment are being actively developed. Patients with partial response may require endoscopic or surgical intervention.
METHOD OF ESTIMATION OF PHYSIOLOGICAL ADAPTATION AND THE RATE OF AGING IN PATIENTS WITH A HISTORY OF EMOTIONAL STRESS IN COMBAT SITUATION
Authors: Bulgakova SV V , Treneva EV V , Zakharova NO O , Komarova MV V
Published: October 2020

Aim - to develop an automated program for the evaluation of physiological adaptation of the cardiovascular system for combat veterans. Materials and methods. The study included 60 male patients, average age 53.13 ± 2.9 years, who participated in combat operations in Afghanistan (1979 - 1989) and Chechnya (1994 - 2002). The study of adaptive homeostasis of the cardiovascular system is made on cellular, microvascular, cardiovascular and organ levels. Results. The veterans of combat operations are characterized by disturbances in the psychological, physiological and social adaptation, which leads to premature aging. The cardiovascular system is highly reactive and plays a major role in the adaptive changes of the functional state of the organism. Based on the model of canonical correlation with step-by-step inclusion and exclusion of predictors, parameters of the cardiovascular system, a computer system for assessment of the degree of adaptation was developed. Conclusion. The developed automated system can be used in treatment, prophylactic and rehabilitation institutions, as well as in research and education centers for the diagnosis and monitoring of the effectiveness of therapeutic and rehabilitation measures.
CYTOKINE PROFILE AND IMPORTANCE OF ITS ASSESSMENT IN FORECASTING THE COURSE OF DUST DISEASES OF THE LUNGS
Authors: Babanov SA A , Budash DS S
Published: October 2020

Aim - study of cellular immunity and cytokine profile in dust lung diseases caused by exposure to aerosols of various degrees of fibrogenity; assessment of the role of immunological changes in the pathogenesis of occupational lung diseases of dust aetiology. Materials and methods. 161 patients from the contact group with chronic dust bronchitis, silicosis and pneumoconiosis due to exposure to welding aerosols were examined. The control group included 60 people who did not have contact with occupational hazards at work and who were declared healthy according to complete physical examination. The diagnosis was made on the basis of professional anamnesis, sanitary-hygienic characteristics of working conditions (work in contact with aerosols of various degrees of fibrogenity), and a complete clinical and instrumental examination of patients. The levels of cytokines IL-1a, IL-ф, IL-4, IL-8, TNF-a, IFN-y and fibronectin in the blood serum were determined using enzyme-linked immunosorbent assay. Results. The specific features of the course of dust diseases of the lungs were revealed (identified features of the cytokine profile, hypercytokinaemia of a significant number of cytokines), which allows us to characterize the occurrence and the progression of dust diseases of the lungs. Conclusion. Determination of the cytokine profile allows us not only to improve the quality of early detection, but also to optimize the strategy of primary and secondary prophylaxis of this disease, to predict the course of the disease, and to reduce the number of disabling forms.
OPTIMIZATION OF INDICATIONS FOR THORACOSCOPY IN CHEST TRAUMA
Authors: Korymasov EA A , Benyan AS
Published: October 2020

Background. The terms for application of video-assisted endosurgical interventions appear rather often in the surgery of chest trauma. There is a certain need for clear selection and differentiation of indications and contraindications for performing thoracoscopy and other operations. Materials and methods. The 3-years’ experience of treatment of patients with blunt chest trauma and penetrating wounds is described in the article. There was prevalence of patients with isolated blunt chest trauma (35.1%) and penetrating thoracic wounds (29.0%). We have performed thoracoscopy for 107 patients. Emergency thoracoscopy had been done in 38 cases (35.5%), urgent thoracoscopy in 27 (25.2%) and delayed thoracoscopy - in 42 patients (39.3%). The rate of thoracotomy was 14.9%. Results and discussion. The indications for thoracoscopy at chest trauma were defined. The analysis of treatment results depending on the kind of traumatic lesion and operation method was carried out. The best results were obtained in patients with isolated blunt chest trauma and those who underwent thoracoscopy. The role of thoracoscopy in case of urgent and delayed indications for surgery was emphasized. We registered complications in 13.5% of patients with blunt chest trauma and 6.1% of patients with penetrating wounds. The general mortality was 3.8%. Conclusion. We can conclude that the results of treatment of patients with blunt chest trauma and penetrating wounds depend on the severity of the trauma, terms and quality of special medical management and wide application of thoracoscopy.
EPIDEMIOLOGICAL FEATURES OF HIV INFECTION IN MODERN CONDITIONS ON THE EXAMPLE OF THE SAMARA REGION)
Authors: Borisova OV V , Agafonova OV V , Eremenko EP P , Borodulina EV V
Published: October 2020

High spread of HIV infection (more than 0,5% among the population) was registered in 26 regions of the Russian : Federation, where 41,5% of the country's population live. Aim - to estimate the dynamics of the spread of HIV infection in the region that used to be among the regions most affected by HIV-infection in the Russian Federation; to determine the state of HIV infection among women and children. Materials and methods. The official reporting data ; of the State Regional Clinical Hospital "Samara Regional Center for the Prevention and Control of AIDS and : Infectious Diseases" were used. Results. As of 1 January 2017, Samara region is on the 13th place in terms of morbidity due to HIV (104.1 per 100 000 population). Increase in the birth rate of children born from HIV-infected mothers has been observed since 2002 (10,365 children were born in the Samara Region : since the beginning of the epidemic). The diagnosis of "HIV infection" was confirmed in 494 children. Conclusion. Characteristic features ofthe HIV epidemic in the Samara region are: the greatest prevalence of disease in the big cities of the region with further expansion into smaller towns and rural areas. There is the predominance of the sexual mode of transmission at present time. Evolution of the infection is manifested by an increase in the number of infected women, which account for about 40,0% of HIV cases. The rate of detectable HIV infection in pregnant women is growing at a consistently high level, and the proportion of births among HIV-infected pregnant women is increasing. The total cumulative percentage of perinatal HIV infection was 4,8% (0.8% - in 2016).