bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative analysis of physiological variations and genetic architecture for cold stress response in soybean germplasm
Authors: Hussain Muhammad Azhar , Li Senquan , Gao Hongtao , Feng Chen , Sun Pengyu , Sui Xiangpeng , Jing Yan , Xu Keheng , Zhou Yonggang , Zhang Wenping , Li Haiyan
Published: January 2023

Soybean (Glycine max L.) is susceptible to low temperatures. Increasing lines of evidence indicate that abiotic stress-responsive genes are involved in plant low-temperature stress response. However, the involvement of photosynthesis, antioxidants and metabolites genes in low temperature response is largely unexplored in Soybean. In the current study, a genetic panel of diverse soybean varieties was analyzed for photosynthesis, chlorophyll fluorescence and leaf injury parameters under cold stress and control conditions. This helps us to identify cold tolerant (V100) and cold sensitive (V45) varieties. The V100 variety outperformed for antioxidant enzymes activities and relative expression of photosynthesis (Glyma.08G204800.1, Glyma.12G232000.1), GmSOD (GmSOD01, GmSOD08), GmPOD (GmPOD29, GmPOD47), trehalose (GmTPS01, GmTPS13) and cold marker genes (DREB1E, DREB1D, SCOF1) than V45 under cold stress. Upon cold stress, the V100 variety showed reduced accumulation of H2O2 and MDA levels and subsequently showed lower leaf injury compared to V45. Together, our results uncovered new avenues for identifying cold tolerant soybean varieties from a large panel. Additionally, we identified the role of antioxidants, osmo-protectants and their posttranscriptional regulators miRNAs such as miR319, miR394, miR397, and miR398 in Soybean cold stress tolerance.
Phytohormones regulate the abiotic stress: An overview of physiological, biochemical, and molecular responses in horticultural crops
Authors: Zheng Yi , Wang Xiaonan , Cui Xin , Wang Kefeng , Wang Yong , He Yuhui
Published: January 2023

Recent changing patterns of global climate have turned out to be a severe hazard to the horticulture crops production. A wide range of biotic and abiotic stresses often affect plants due to their sessile nature. Horticultural crop losses are mainly caused by abiotic factors such as drought, salt, heat, cold, floods, and ultraviolet radiation. For coping up with these adversities, well-developed mechanisms have been evolved in plants, which play a role in perceiving stress signals and enabling optimal growth responses. Interestingly, the use of phytohormones for suppressing the impact of abiotic stress has gained much attention in recent decades. For circumvention of stress at various levels, including physiological, molecular, as well as biochemical, a sophisticated mechanism is reported to be provided by the phytohormones, thus labeling these phytohormones a significant role in plant growth and development. Phytohormones can improves tolerance against abiotic stresses by increasing seed germination, seedling growth, leaf photosynthesis, root growth, and antioxidant enzymes and reducing the accumulation of reactive oxygen species, malonaldehyde, and electrolyte leakage. Recent discoveries highlight the significant role of a variety of phytohormones including melatonin (MEL), Gamma-aminobutyric acid (GABA), jasmonic acid (JA), salicylic acid (SA), brassinosteroids (BRs), and strigolactones (SLs) in abiotic stress tolerance enhancement of horticultural plants. Thus, current review is aimed to summarize the developmental concepts regarding role of phytohormones in abiotic-stress mitigation, mainly in horticultural crops, along with the description of recent studies which identified the role of different phytohormones in stressed environments. Hence, such a review will help in paving the path for sustainable agriculture growth via involvement of phytohormones in enhancement of abiotic stress tolerance of horticultural crops.
Application of chloroplast genome in the identification of Phyllanthus urinaria and its common adulterants
Authors: Fang Hui , Dai Guona , Liao Binbin , Zhou Ping , Liu Yinglin
Published: January 2023

Background

Phyllanthus urinaria L. is extensively used as ethnopharmacological material in China. In the local marketplace, this medicine can be accidentally contaminated, deliberately substituted, or mixed with other related species. The contaminants in herbal products are a threat to consumer safety. Due to the scarcity of genetic information on Phyllanthus plants, more molecular markers are needed to avoid misidentification.

Methods

In this study, the complete chloroplast genome of nine species of the genus Phyllanthus was de novo assembled and characterized.

Results

This study revealed that all of these species exhibited a conserved quadripartite structure, which includes a large single copy (LSC) region and small single copy (SSC) region, and two copies of inverted repeat regions (IRa and IRb), which separate the LSC and SSC regions. And the genome structure, codon usage, and repeat sequences were highly conserved and showed similarities among the nine species. Three highly variable regions (trnS-GCU-trnG-UCC, trnT-UGU-trnL-UAA, and petA-psbJ) might be helpful as potential molecular markers for identifying P. urinaria and its contaminants. In addition, the molecular clock analysis results showed that the divergence time of the genus Phyllanthus might occur at ~ 48.72 Ma.

Conclusion

This study provides valuable information for further species identification, evolution, and phylogenetic research of Phyllanthus.
Negative regulation of floral transition in Arabidopsis by HOS15-PWR-HDA9 complex
Authors: Lim Chae Jin , Park Ki Suk , Ali Akhtar , Park Junghoon , Ryou Seung Min , Shen Mingzhe , Khan Haris Ali , Bader Zein Eddin , Zareen Shah , Bae Min Jae , Choi Jong Hyoo , Xu Zheng-Yi , Pardo Jose M. , Yun Dae-Jin
Published: January 2023

Arabidopsis HOS15/PWR/HDA9 repressor complex, which is similar to the TBL1/NcoR1/HDAC complex in animals, plays a well-known role in epigenetic regulation. PWR and HDA9 have been reported to interact with each other and modulate the flowering time by repressing AGL19 expression, whereas HOS15 and HDA9, together with the photoperiodic evening complex, regulate flowering time through repression of GI transcription. However, the role of the HOS15/PWR/HDA9 core repressor complex as a functional unit in the regulation of flowering time is yet to be explored. In this study, we reported that the loss-of-function hos15-2/pwr/hda9 triple mutant accumulates higher transcript levels of AGL19 and exhibits an early flowering phenotype similar to those of hos15, pwr, and hda9 single mutants. Interestingly, the accumulation of HOS15 in the nucleus was drastically reduced in pwr and hda9 mutants. As a result, HOS15 could not perform its role in histone deacetylation or interaction with H3 in the nucleus. Furthermore, HOS15 is also associated with the same region of the AGL19 promoter known for PWR-HDA9 binding. The acetylation level of the AGL19 promoter was increased in the hos15-2 mutant, similar to the pwr and hda9 mutants. Therefore, our findings reveal that the HOS15/PWR/HDA9 repressor complex deacetylates the promoter region of AGL19, thereby negatively regulating AGL19 transcription, which leads to early flowering in Arabidopsis.
Music therapy effect on anxiety reduction among patients with cancer: A meta-analysis
Authors: Zang Lu , Cheng Chunliang , Zhou Yongxin , Liu Xuemei
Published: January 2023

Introduction

The study aimed to investigate the effect of music therapy on anxiety alleviation among cancer patients.

Methods

A comprehensive literature research was performed in four electronic databases (PubMed, Embase, Cochrane Library, and Web of Science). Fifteen randomized controlled trials (RCTs) were included. The risk of bias for the RCTs was evaluated by the Cochrane Risk of Bias tool. Anxiety levels were extracted to synthesize the combined effect by using meta-analysis. All analyses were performed using R version 4.0.4.

Results

In total, 15 RCTs met the inclusion criteria involving 1320 cancer patients (662 patients in the experimental group and 658 patients in the controlled group). The majority of interventions were performed with recorded music lasting for 15-60 minutes. Compared with standard care, music intervention had a moderate superiority of anxiety alleviation (SMD: –0.54, 95% CI: [–0.92, –0.16]).

Discussion

Music intervention could reduce cancer-related anxiety moderately. Nevertheless, the result should be interpreted with caution as high heterogeneity in this pooled study. Well-designed trials with higher quality were still warranted in the future.
The matching rule of Panum’s limiting case and its influencing factors
Authors: Shi Yuyu , He Ziyi , Deng Yuzhen , Li Huayun
Published: January 2023

Introduction

Panum’s limiting case is one of the typical configurations of monocular occlusion region. The matching rule of Panum’s limiting case is the key to understanding how monocular occlusion region produces stereopsis. There are currently two main views on the matching rule of Panum’s limiting case, namely double fusion and uniqueness constraint. This paper further discusses its matching mechanism on the basis of previous studies.

Methods

In this study, fold line Panum’s stimuli were used to study the matching rule of Panum’s limiting case. In Experiment 1, fixation position was adopted to present the stimulus in a short time to explore the matching rules in Panum’s limiting case. In Experiment 2, the effect of fixation position on Panum’s limiting case matching results was further investigated.

Results

The results of Experiment 1 show that when stimuli are presented in a short period of time, the reported result that a single feature in one eye may be matched alternately with two features in the other eye. This matching rule is called “fast alternative matching” in this article. The results of Experiment 2 results show that the position of the fixation could affect the matching result of participants.

Conclusion

In conclusion, the matching rule of Panum’s limiting case is fast alternative matching, and the matching result is related to the attention state of the participant. These results not only provide a new perspective for matching rules in Panum’s limiting case, but also show that depth perception results in stereopsis can be influenced by top-down cognitive processing. This study provides a theoretical basis for studying the formation of stereopsis in the monocular region to a certain extent. In summary, the matching rule of Panum’s limiting case is fast alternative matching. In previous studies, the perceived result of double fusion may be caused by fast alternative matching. Also, the matching results are related to the participant’s state of attention, which suggests that the depth perception results of stereopsis are influenced by top-down cognitive processing.
Cortisol reactivity to psychosocial stress in vulnerable and grandiose narcissists: An exploratory study
Authors: Borráz-León Javier I. , Spreitzer Alena , Scrivner Coltan , Landers Mitchell , Lee Royce , Maestripieri Dario
Published: January 2023

Introduction

Narcissistic personality manifests itself in at least two different forms: grandiose and vulnerable. In the present study, we compared cortisol and emotional responses to psychosocial stress between subjects high in vulnerable and grandiose narcissism scores, and examined possible associations between narcissism, other personality traits, and stress responses. We hypothesized that subjects with higher scores of vulnerable narcissism would show stronger emotional and physiological reactivity than those with high scores of grandiose narcissism.

Methods

A final sample of forty-seven participants underwent a Trier Social Stress Test (TSST), provided saliva samples to assess cortisol levels, and completed several personality questionnaires.

Results

Consistent with our hypothesis, subjects with higher scores of vulnerable narcissism had a stronger cortisol and emotional response than those with high scores of grandiose narcissism. Vulnerable narcissism was positively correlated with schizotypal traits, while grandiose narcissism was positively correlated with psychopathic traits. Participants with a mixed-type of narcissism were also discussed.

Discussion

This study provides the first evidence of differential physiological and emotional reactivity to social evaluation threat according to scores of vulnerable and grandiose narcissism. Since this is an exploratory study, the results must be interpreted with caution. However, the results will be informative for future confirmatory research with larger and more heterogeneous samples.
Needs and expectations of family caregivers of cancer patients in palliative care: A study protocol
Authors: Fernandes Júlio Belo , Domingos Josefa , Castro Cidália , Simões Aida , Fernandes Sónia , Almeida Ana Silva , Bernardes Catarina , Miranda Luís , Risso Sandra , Ferreira Rogério , Baixinho Cristina Lavareda , Silvestre Milene , Godinho Catarina
Published: January 2023

Cancer has an associated burden that continues to grow, affecting patients, family caregivers, and the individual’s community. The family caregivers’ unmet needs may harmfully jeopardize their well-being and the patient’s health outcomes. Therefore, it is essential to understand the needs and expectations of family caregivers of cancer patients to develop and improve care practices. The present study aims to explore the needs and expectations of family caregivers of cancer patients in palliative care. This qualitative, descriptive exploratory study will use purposive sampling to recruit family caregivers and healthcare professionals from the palliative care units of two hospital centers in Lisbon and Tagus Valley. First, the Focus group will be performed until data saturation occurs. Then, a conventional thematic analysis will be applied to analyze data with the help of the coding software QDA Miner Lite database. This study’s findings will help identify gaps in care and provide data that can support healthcare professionals in providing evidence-based centered care to family caregivers. It can also generate knowledge that may help stakeholders to develop a comprehensive support system for cancer survivors in palliative care and their family caregivers.
Smartphone addiction and phubbing behavior among university students: A moderated mediation model by fear of missing out, social comparison, and loneliness
Authors: Safdar Bajwa Ruqia , Abdullah Haslinda , Zaremohzzabieh Zeinab , Wan Jaafar Wan Munira , Abu Samah Asnarulkhadi
Published: January 2023

Introduction

This article examines mediators and moderators that may explain the link between smartphone addiction and phubbing behavior using a sample of 794 university students.

Methods

A mediation model was tested to test the hypothesis that social comparison orientation and fear of missing out would mediate the link between smartphone addiction and phubbing behavior. Additionally, a moderated mediation model was leveraged to examine loneliness as a moderator within the hypothesized model. The data collected were analyzed using SPSS.

Results and Discussion

The findings show a significant positive relationship between smartphone addiction and phubbing behavior. The findings confirm the hypothesized associations and reveal that smartphone addiction is positively linked to phubbing behavior. The link, on the other hand, is partially and sequentially mediated by the fear of missing out and social comparison orientation. As a result, both mediators might be regarded as proximal variables of phubbing behavior. Moreover, the associations between both smart addiction and phubbing behaviors as well as social comparison orientation and phubbing behaviors are moderated by loneliness. These two effects were stronger for university students with high loneliness than for those with low loneliness. This study addresses a major gap in the clinical psychology literature through the attempt to explore the relationship between smartphone addiction and increased phubbing behavior among university students.
The effect of chronic regulatory focus and social comparison on undergraduates’ intertemporal choices under gain-loss frame
Authors: Liu Dan , Zhang Yuan , Geng Xiaowei
Published: January 2023

Intertemporal choice refers to decisions involving tradeoffs among costs and benefits occurred at different times. To investigate whether college students’ intertemporal decision making under the gain and loss frames is affected by their chronic regulatory focus. Currently, experiment 1 investigated the influence of college students’ chronic regulatory focus on intertemporal decision making under the gain and loss frames, and experiment 2 further explored the moderating effect of social comparison (i.e., upward or downward social comparison) during this process. The results showed that intertemporal choices of participants with promotive focus was no significant difference between the gain frame and loss frame, while college students with preventive focus chose later and larger rewards more in loss frame than in gain frame. Social comparison moderated the effects of the chronic regulatory focus on college students’ intertemporal choice in gain and loss frames. The upward comparison enhanced the influence of regulatory focus on intertemporal choice in the gain and loss frames, while the downward comparison weakened it.
Stories of hope created together: A pilot, school-based workshop for sharing eco-emotions and creating an actively hopeful vision of the future
Authors: Marks Elizabeth , Atkins Ed , Garrett Joanne K. , Abrams Jesse F. , Shackleton David , Hennessy Lauren , Mayall Elouise E. , Bennett James , Leach Isabel
Published: January 2023

The climate and ecological crises challenge all communities across the world, with the greatest impact upon the most vulnerable and the youngest. There are multiple impacts on mental health, including the psychological burdens that arise with increasing awareness of the loss, threat and injustice caused by these crises. Large numbers of young people globally are understandably concerned and distressed about these crises, whilst simultaneously reporting that their concerns are regularly dismissed and ignored, particularly by those in power. This can increase feelings of isolation and distress, particularly if they have no recourse to effect change. This pilot project sought to explore how a schools-based, co-created workshop for school pupils aged 16 to 18 years could use a community-oriented space to explore their eco-emotions, address feelings of isolation and engender a sense of realistic, active hope, using storytelling and images of possible futures. A 3-h workshop for delivery in schools was co-designed with young people, researchers, educators and clinicians, using principles of Youth Participatory Action Research (YPAR). Six school pupils aged 16–18 years consented and four completed the workshop, which involved a range of group-based activities to explore their understanding of the climate and ecological crises, support emotional expression related to these and engage in storytelling about hopeful and realistic futures. A live illustrator in attendance created shared images of the participants’ fears and hopes. The workshop was recorded, transcribed and analysed using Thematic Analysis and sentiment analysis. Feedback was sought from participants at 1 and 4 weeks after completion and analysed using content analysis. Results indicated that participants reported a range of painful and positive emotions about the crises. They highly valued having space to express their experience alongside others. Storytelling and creativity appeared to help them articulate their feelings and hopes for the future, and gave them greater motivation and confidence in talking to others about these topics. This innovative pilot study suggests that a school-based youth participatory group could offer a novel way of helping young people to engage more with the climate and ecological crises in a way that supports their wellbeing. It provides strong support for future, larger-scale projects in this area.
How does interactive virtual reality enhance learning outcomes via emotional experiences? A structural equation modeling approach
Authors: Yang Hairu , Cai Minghan , Diao Yongfeng , Liu Rui , Liu Ling , Xiang Qianchen
Published: January 2023

Introduction

Interest in interactive virtual reality (IVR) is increasing due to its potential for embodied learning and group-led teaching. However, few studies have investigated the internal mechanism by which IVR technology features and learning experiences affect learning outcomes in terms of psychological and emotional value. Based on media technology models and the control value theory of achievement emotions (CVTAE), this study uses structural equation modeling (SEM) to investigate the correlations among the internal elements of IVR technology features, learning experiences, and learning outcomes. It also emphasizes the role played by emotional experience in this context.

Methods

The sample referenced by this study consisted of 480 college students (193 males) who were simultaneously engaged in guided inquiry and learning in an IVR-based COVID-19 pandemic science museum in groups of 10.

Results

The findings suggest that presence and perceived enjoyment have a key mediating effect on the relationship between virtual reality (VR) features and perceived learning outcomes in an IVR-based learning simulation. In addition, the results indicate that presence is more strongly correlated with perceived learning effects, while enjoyment is more strongly correlated with learning satisfaction.

Discussion

These findings provide intellectual support and theoretical backing for VR-based instructional design and environmental development. Moreover, this study has practical value with regard to the future large-scale application of IVR to experiential teaching, group-led teaching, and the promotion of the digital transformation and intelligence upgrading in education.
Psychological distress, emotion regulation, neuroticism, and sexual relationship on patients with temporary ejaculation failure in vitro fertilization-embryo transfer treatment
Authors: Zhang Xinting , Yang Lexia , Wang Wei , Yang Lejin
Published: January 2023

Objective

Temporary ejaculation failure on the oocyte retrieval day might leading interruption of the oocyte retrieval procedure. The present study aims to understand the psychosocial factor that affects men with temporary ejaculation failure (TEF)in Vitrofertilization-embryo transfer (IVF-ET) patients, and thus provide new ideas for optimal clinical treatment.

Study design

In a prospective study, the male patients during IVF treatment in a reproductive center of a tertiary hospital in Shandong were divided into two groups, 70 men with TEF and 79 normal controls. General population sociology and clinical disease were investigated, and the Kessler 10 scale, emotion regulation questionnaire, big five inventory questionnaire, and sex subscale of marriage quality were used to assess the psychological distress, emotion regulation, neuroticism, and satisfaction with sexual life.

Results

The scores of perceived distress and neuroticism of the TEF group were higher than the non-TEF group (p < 0.001), and cognitive reappraisal and sexual relationship were significantly lower than those in the non-TEF group (p < 0.001). Psychological distress (OR 1.130,p = 0.031) and neuroticism (OR 1.096,p = 0.050) were risk factors for TEF, while cognitive reappraisal (OR 0.883,p = 0.004) and sexual relationship (OR 0.712,p < 0.001) was protective factors.

Conclusion

The present study demonstrates that psychosocial factors influence TEF in IVF-ET patients, which provides the basis for the prevention of the occurrence of TEF in a male undergoing IVF-ET.
Measurement invariance of the empowering and disempowering motivational climate questionnaire-coach in youth sport
Authors: Appleton Paul R. , Viladrich Carme , Quested Eleanor , González-García Lorena , Papaioannou Athanasios , Hall Howard K. , Balaguer Isabel , Ramis Yago , Sarrazin Philippe , Heuzé Jean-Philippe , Ommundsen Yngvar , Wold Bente , Samdal Oddrun , Duda Joan L.
Published: January 2023

The purpose of this study was to test the measurement invariance (across five languages, two time points, and two experimental conditions) of the empowering and disempowering motivational climate questionnaire-coach (EDMCQ-C; Appleton et al., 2016) when completed by 9256 young sport participants (M age = 11.53 years, SD = 1.39 years; 13.5% female). Exploratory Structural Equation Modeling was used to test the validity of a 2-factor (empowering and disempowering) model running a multiple group analysis without any equality constraint (configural invariance) followed by measurement invariance of factor loadings and thresholds (scalar invariance). Findings provided support for partial invariance across languages and scalar invariance across time and experimental groups. The factors were interpretable across the analyses, and items loaded as intended by theory except for item 15. This study provides further evidence regarding the psychometric properties of the EDMCQ-C and suggests this scale (minus item 15) can be used to provide meaningful latent mean comparisons (Marsh et al., 2013) of empowering and disempowering coach-created climates across athletes speaking the five targeted languages, across time, and across experimental groups.
Physical activity levels associated with insomnia and depressive symptoms in middle-aged and elderly patients with chronic schizophrenia
Authors: Liu Zhiwei , Zhang Yulong , Sun Liang , Wang Juan , Xia Lei , Yang Yating , Sun Feng , Li Wenzheng , Yao Xianhu , Yang Rongchun , Liu Huanzhong
Published: January 2023

Background

Previous evidence suggested that physical activity had beneficial effects on psychopathological symptoms, insomnia, or depressive symptoms in people with schizophrenia. This study investigated the association between physical activity levels and insomnia and depressive symptoms in middle-aged and elderly hospitalized patients with chronic schizophrenia (CS).

Methods

179 participants were enrolled. We used the 30-item Positive and Negative Syndrome Scale (PANSS–30) to assess the psychopathological symptoms. We used the Insomnia Severity Index scale (ISI) and 17-item Hamilton Depression Scale (HAMD-17) to evaluate insomnia and depressive symptoms. Daily physical activity time less than 30 min, within 30–60 min, and more than 60 min were defined as physical inactivity, moderate physical activity, and vigorous physical activity, respectively. The Chi-square test, analysis of variance (ANOVA), and Mann–Whitney U-test were applied for categorical, continuous, and non-normal distribution variables, respectively. The Pearson or Spearman’s correlation analyses were utilized to examine the association between physical activity levels, ISI total scores, HAMD total scores, and socio-demographic and clinical variables. Finally, socio-demographic variables with a P-value < 0.05 in the comparison between insomnia/depressive group and non-insomnia/depressive group were considered for inclusion in binary logistic regression analysis to determine the relationship between physical activity levels and insomnia or depressive symptoms.

Results

The ISI total scores (r = –0.247, P = 0.001) and HAMD total scores (r = –0.312, P < 0.001) were negatively correlated with physical activity levels. Logistic regression analysis revealed that older age, higher depressive factor scores, and lower physical activity level were influential factors of insomnia symptoms in CS patients (P < 0.05). In addition, vigorous physical activity (compared with physical inactivity) and higher negative and depressive factor scores were independently associated with depressive symptoms in CS patients (P < 0.05).

Conclusion

Physical activity levels were influential factors in comorbid insomnia and depressive symptoms in CS patients. Given the benefits of physical activity, it should be strengthened as a routine adjunct to clinical treatment or psychiatric care so as to improve the physical and mental health of patients with psychiatric symptoms.
Developmental diversity: Putting the development back into research about developmental conditions
Authors: Hens Kristien , Van Goidsenhoven Leni
Published: January 2023

The dominant discourse surrounding neurodevelopmental conditions such as autism and ADHD emphasizes biological explanations. Neurodevelopmental conditions are conceived as different types of brains, the result of different types of genes. This way of thinking is present both in medical research and in clinical practice. Indeed, it is widely acknowledged that the idea of having a biological diagnosis helps people see beyond blame and guilt. It aids acceptance. However, simplistic approaches to biology risks neglecting the experiences and stories of autistic people in favor of finding etiological causes. At the same time, there is growing awareness that risks, functioning, and resilience are not solely defined by genes and brains but have a cultural and experiential component as well. Furthermore, atypical cognitive trajectories are not straightforwardly associated with poor outcomes. In this paper we describe the concept of developmental diversity as an alternative to more categorical approaches to neurodevelopmental conditions. We explore how dynamic models of life offer possibilities to look at neurodevelopmental conditions differently: rather than seeing autistic people as people with fundamental flaws in their genes or software faults in their brains that have to be explained, autism appears as a phenomenon that exists in interaction with the context, as a meaningful reaction to the environment. We explore what it would mean for research to go from a diagnosis-based approach to a developmental diversity approach that will define wellbeing and functioning in a more granular way across developmental trajectories. We argue that this would mean incorporating lived experiences into biological research and going beyond genes-environment dichotomies. Next to yielding a more complete picture on the phenomenon of autism, we describe how an approach that takes developmental diversity as a starting point offers a new way to look at existing challenges of autism research, such as how to deal with the significant overlap between diagnosis. Our hypothesis is that thinking with developmental diversity rather than categorical difference both represents an opportunity for a more inclusive society, and fundamentally can alter the way we perform research. As such, it is in line with requests of neurodiversity and disability movements.
Air pollution burden of disease over highly populated states in the Middle East
Authors: Isaifan Rima J.
Published: January 2023

Background

Recent epidemiological research has proven that air pollution triggers the risk of morbidity and mortality due to respiratory and cardiovascular-related diseases. More specifically, fine particulate matter with a diameter of <2.5 μm (PM2.5) can penetrate deeply into the lung and bloodstream, causing critical adverse effects on human health.

Objective

It is found that there is inadequate published research related to the health impact of ambient air pollution in the Middle East region. Some states are well studied, while others are not. This work aims to evaluate the health impact of long-term exposure to PM2.5 in the nine most populated countries in the Middle East region, with a total population of about 363 million (in 2012).

Methods

In this study, the human health impacts in terms of total mortality and the estimated attributable proportion (AP) due to long-term exposure to ambient PM2.5 were estimated using the World Health Organization method and software (AirQ+).

Results

In 2012, the annual median PM2.5 concentrations ranged from 34 μg/m3 in Turkey and Syria to 108 μg/m3 in Saudi Arabia. The total estimated mortalities in the nine most populated countries in the Middle East due to long-term exposure to fine particulate matter was about 152,925 (half of which were residents in Egypt). Moreover, the relative risk (RR) was the highest for Saudi Arabia at 1.8031 and the lowest for Turkey and Syria at a value of 1.1553. The highest AP (central value) was 44.5% in Saudi Arabia, while the lowest was 13.4% in Turkey and Syria.

Conclusions

The results indicate a significant impact of air pollution due to long-term exposure to fine particles resulting in early mortality. This urges the collaboration between the governments and different sectors to adopt stringent regulations to control the anthropogenic sources related to traffic and industrial emissions in the Middle East in order to reduce the health burden of air pollution.
Depression and anxiety in cervical degenerative disc disease: Who are susceptible?
Authors: Sang Dacheng , Xiao Bowei , Rong Tianhua , Wu Bingxuan , Cui Wei , Zhang Jianhao , Zhang Yue , Liu Baoge
Published: January 2023

Background

Pre-operative depression and anxiety are associated with poorer patient-reported outcomes following cervical spine surgery. Identification of and interventions for these disorders are key to preventing related negative effects. However, most spine surgeons do not routinely evaluate mental health disorders. Few studies have investigated which patients with cervical degenerative disc diseases (CDDD) are susceptible to depression and anxiety.

Objective

To determine the factors associated with depression and anxiety in patients with CDDD.

Methods

Three hundred twelve patients with CDDD were recruited in this cross-sectional case-control study. Patients underwent a structured interview to acquire demographic and clinical characteristic information, which included the Neck Disability Index (NDI), modified Japanese Orthopedic Association (mJOA), and Visual Analog Scale (VAS) for neck/arm pain. Depression and anxiety were evaluated using the Zung Self-Rating Depression and Anxiety Scales. Univariate and multivariate logistic regression analyses were used to identify factors associated with depression and anxiety.

Results

Of all patients, 102 (32.7%) had depression and 92 (29.5%) had anxiety. Two hundred six (66.0%) patients with neither depression nor anxiety were defined as the control group. Univariate analysis indicated that gender, educational level, occupation type, Charlson comorbidity index, symptom duration, symptomatology, surgery history, NDI, mJOA, VAS-neck, and VAS-arm scores were associated with depression and anxiety (except for symptom duration for anxiety). Multivariate logistic regression analysis indicated that females [odds ratio (OR) 1.81, 95% confidence interval (CI) 1.01–3.23], physical work (OR 2.06, 95% CI 1.16–3.65), poor mJOA score (ORmoderate 2.67, 95% CI 1.40–5.07; ORsevere 7.63, 95% CI 3.85–15.11), and high VAS-neck score (OR 1.24, 95% CI 1.11–1.39) were independent risk factors for depression. Physical work (OR 1.84, 95% CI 1.01–3.35), poor mJOA score (ORmoderate 2.66, 95% CI 1.33–5.33; ORsevere 9.26, 95% CI 4.52–18.99), and high VAS-neck score (OR 1.34, 95% CI 1.19–1.51) were independent risk factors for anxiety.

Conclusion

Approximately one-third of patients with CDDD had depression or anxiety. Patients who engaged in heavy work and had severe symptoms (poor mJOA and high VAS-neck scores) are susceptible to depression and anxiety. Additionally, female patients are susceptible to depression. Our findings may help identify CDDD patients with depression and anxiety in clinical practice.
Research on the sustainable development of agricultural product supply chain in three northeast provinces in China
Authors: Fan Xuemei , Zhang Yingdan , Ma Yuanhang , Zhao Cong , Liang Buxin , Chu Hao
Published: January 2023

Background

The sustainable development of the agricultural product supply chain (APSC) is the key to protecting public health.

Methods

This paper explores the sustainable development status of the APSC in three northeast provinces of China from 2007 to 2020 and the development trend in the next 5 years by using the entropy weight—matter-element extension model (MEEM) and autoregressive integrated moving average model (ARIMA), taking into account the background of relatively backward development and the high proportion of agricultural output in these three provinces.

Results

According to the research results, the sustainable development of the APSC in Jilin Province is relatively stable, Heilongjiang Province has made considerable progress in the sustainable development of the APSC in recent years, while Liaoning Province has shown a significant downward trend in recent years in the sustainable development of the APSC, despite a strong development momentum in previous years.

Conclusions

The findings of this paper can be applied to the governance of APSC in other rural areas with uneven development. The assessment also provides guidance on the quality and safety of agricultural products and public health, and raises the awareness of policymakers on the importance of the APSC.
Medical implementation practice and its medical performance evaluation of a giant makeshift hospital during the COVID-19 pandemic: An innovative model response to a public health emergency in Shanghai, China
Authors: Chen Minjie , Fan Yiling , Xu Qingrong , Huang Hua , Zheng Xinyi , Xiao Dongdong , Fang Weilin , Qin Jun , Zheng Junhua , Dong Enhong
Published: January 2023

Introduction

In confronting the sudden COVID-19 epidemic, China and other countries have been under great pressure to block virus transmission and reduce fatalities. Converting large-scale public venues into makeshift hospitals is a popular response. This addresses the outbreak and can maintain smooth operation of a country or region's healthcare system during a pandemic. However, large makeshift hospitals, such as the Shanghai New International Expo Center (SNIEC) makeshift hospital, which was one of the largest makeshift hospitals in the world, face two major problems: Effective and precise transfer of patients and heterogeneity of the medical care teams.

Methods

To solve these problems, this study presents the medical practices of the SNIEC makeshift hospital in Shanghai, China. The experiences include constructing two groups, developing a medical management protocol, implementing a multi-dimensional management mode to screen patients, transferring them effectively, and achieving homogeneous quality of medical care. To evaluate the medical practice performance of the SNIEC makeshift hospital, 41,941 infected patients were retrospectively reviewed from March 31 to May 23, 2022. Multivariate logistic regression method and a tree-augmented naive (TAN) Bayesian network mode were used.

Results

We identified that the three most important variables were chronic disease, age, and type of cabin, with importance values of 0.63, 0.15, and 0.11, respectively. The constructed TAN Bayesian network model had good predictive values; the overall correct rates of the model-training dataset partition and test dataset partition were 99.19 and 99.05%, respectively, and the respective values for the area under the receiver operating characteristic curve were 0.939 and 0.957.

Conclusion

The medical practice in the SNIEC makeshift hospital was implemented well, had good medical care performance, and could be copied worldwide as a practical intervention to fight the epidemic in China and other developing countries.
A novel Energy Resources Allocation Management model for air pollution reduction
Authors: Khorsandi Armita , Li Liping
Published: January 2023

Although air pollution has been reduced in various industrial and crowded cities during the COVID-19 pandemic, curbing the high concentration of the crisis of air pollution in the megacity of Tehran is still a challenging issue. Thus, identifying the major factors that play significant roles in increasing contaminant concentration is vital. This study aimed to propose a mathematical model to reduce air pollution in a way that does not require citizen participation, limitation on energy usage, alternative energies, any policies on fuel-burn style, extra cost, or time to ensure that consumers have access to energy adequately. In this study, we proposed a novel framework, denoted as the Energy Resources Allocation Management (ERAM) model, to reduce air pollution. The ERAM is designed to optimize the allocation of various energies to the recipients. To do so, the ERAM model is simulated based on the magnitude of fuel demand consumption, the rate of air pollution emission generated by each energy per unit per consumer, and the air pollution contribution produced by each user. To evaluate the reflectiveness and illustrate the feasibility of the model, a real-world case study, i.e., Tehran, was employed. The air pollution emission factors in Tehran territory were identified by considering both mobile sources, e.g., motorcycles, cars, and heavy-duty vehicles, and stationary sources, e.g., energy conversion stations, industries, and household and commercial sectors, which are the main contributors to particulate matter and nitrogen dioxide. An elaborate view of the results indicates that the ERAM model on fuel distribution could remarkably reduce Tehran's air pollution concentration by up to 14%.
Limits to lifespan growth
Authors: Gonçalves Marta , Weon Byung Mook
Published: January 2023

A long-standing human lifespan debate is revival, and the consensus is yet to come on whether the maximum human lifespan is reaching a limit or not. This study discusses how mathematical constraints inherent in survival curves indicate a limit on maximum lifespans, implying that humans would have inevitable limits to lifespan growth.
Dietary fiber intake and non-alcoholic fatty liver disease: The mediating role of obesity
Authors: Zhu Yu , Yang Hu , Zhang Yaozong , Rao Songxian , Mo Yufeng , Zhang Honghua , Liang Shaoxian , Zhang Zhuang , Yang Wanshui
Published: January 2023

Background and aims

Dietary pattern rich in fiber is negatively associated with the risk of non-alcoholic fatty liver disease (NAFLD). Meanwhile, obesity is a known predisposing factor for NAFLD. Nutrient-focused research can enhance the mechanistic understanding of dietary effects. We thus hypothesized that higher dietary fiber intake was associated with lower risk of NAFLD through the mediating role of obesity.

Methods

In this nationwide cross-sectional study, dietary fiber was surveyed using two 24-h recalls. NAFLD and clinically significant fibrosis (CSF) were determined by vibration-controlled transient elastography. Multivariable logistic and linear regression were applied to investigate the association of dietary fiber with NAFLD, CSF, and liver function parameters. We used counterfactual-based mediation analysis to estimate the direct and indirect effect of dietary fiber on NAFLD.

Results

Of the 3,974 participants, ~36.86% and 7.78% of participants were diagnosed with NAFLD and CSF. Compared with participants among the lowest tertile, the highest tertile of dietary fiber consumption was associated with lower odds of NAFLD (OR = 0.81; 95% CI: 0.66–0.98; Poverall = 0.019). Dietary fiber intake appeared to be linked with lower odds of CSF (ORTertile3vs.Tertile1 = 0.81; 95% CI: 0.58–1.14; Poverall = 0.107). Mediation analysis showed that obesity fully mediated the association of dietary fiber with NAFLD. Dietary fiber was associated with improved hepatic parameters.

Conclusions

The findings indicated that increasing dietary fiber intake could confer a greater benefit to protect against NAFLD. Translating these findings regarding dietary fiber into dietary advice might be an attractive strategy for NAFLD prevention.
Influence of academic stress and school bullying on self-harm behaviors among Chinese middle school students: The mediation effect of depression and anxiety
Authors: Chen Hui , Guo Huijuan , Chen Haiyan , Cao Xia , Liu Jiali , Chen Xianliang , Tian Yusheng , Tang Huajia , Wang Xiaoping , Zhou Jiansong
Published: January 2023

Objective

The purpose of this study was to explore the relationship between academic stress, school bullying and self-harm behaviors among Chinese middle school students and to further explore the impact of anxiety and depression on this relationship.

Methods

The students (aged 12–16 years) in a middle school in Changsha city were invited to respond to a questionnaire through an online platform. The Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) were used to assess the severity of anxiety and depressive symptoms, respectively. The experience of being bullied, academic stress, and self-harm behaviors were assessed using several questions on the basis of previous studies.

Results

A total of 1,313 middle school students completed the study, and 3.40% and 4.10% of them reported suicide attempts (SAs) and non-suicidal self-injury (NSSI), respectively. Univariate logistic regression analysis revealed that anxiety symptoms (OR = 1.23, 95% CI: 1.18–1.28; OR = 1.25, 95% CI: 1.19–1.31), depressive symptoms (OR = 1.20, 95% CI: 1.16–1.25; OR = 1.26, 95% CI: 1.20–1.31), school bullying (OR = 3.8, 95% CI: 2.11–6.89; OR = 2.76, 95% CI: 1.39–5.47), and academic stress (OR = 2.20, 95% CI: 1.27–3.80; OR = 3.80, 95% CI: 1.20–7.25) were common factors of NSSI and SAs. In addition, depressive symptoms showed a mediating effect on the association of school bullying and academic stress with SAs or NSSI, and anxiety symptoms showed a mediating effect on the association of school bullying and academic stress with NSSI only.

Conclusion

Appropriate strategies are needed to reduce academic pressure and prevent school bullying. Meanwhile, negative emotions such as depression and anxiety should be evaluated and intervened in to prevent self-harm behaviors among middle school students.