bluuebunny/crossref_metadata_2025 huggingface dataset:
Innovation Process and Industrial System of US Food and Drug Administration–Approved Software as a Medical Device: Review and Content Analysis (Preprint)
Authors: Yu Jiakan , Zhang Jiajie , Sengoku Shintaro
Published: March 2023

BACKGROUND

There has been a surge in academic and business interest in software as a medical device (SaMD). SaMD enables medical professionals to streamline existing medical practices and make innovative medical processes such as digital therapeutics a reality. Furthermore, SaMD is a billion-dollar market. However, SaMD is not clearly understood as a technological change and emerging industry.

OBJECTIVE

This study aims to review the landscape of SaMD in response to increasing interest in SaMD within health systems and regulation. The objectives of the study are to (1) clarify the innovation process of SaMD, (2) identify the prevailing typology of such innovation, and (3) elucidate the underlying mechanisms driving the SaMD innovation process.

METHODS

We collected product information on 581 US Food and Drug Administration–approved SaMDs from the OpenFDA website and 268 company profiles of the corresponding manufacturers from Crunchbase, Bloomberg, PichBook.com, and other company websites. In addition to assessing the metadata of SaMD, we used correspondence and business process analysis to assess the distribution of intended use and how SaMDs interact with other devices in the medical process.

RESULTS

The current SaMD industry is highly concentrated in medical image processing and radiological analysis. Incumbents in the medical device industry currently lead the market and focus on incremental innovation, whereas new entrants, particularly startups, produce more disruptive innovation. We found that hardware medical device functions as a complementary asset for SaMD, whereas how SaMD interacts with the complementary asset differs according to its intended use. Based on these findings, we propose a regime map that illustrates the SaMD innovation process.

CONCLUSIONS

SaMD, as an industry, is nascent and dominated by incremental innovation. The innovation process of the present SaMD industry is shaped by data accessibility, which is key to building disruptive innovation.
Measuring the Potential Effects of Mirror Therapy Added to the Gold Standard Facial Neuromuscular Retraining in Patients With Chronic Peripheral Facial Palsy: Protocol for a Randomized Controlled Trial (Preprint)
Authors: Dagenais Frédéric , Neville Catriona , Desmet Liesbet , Martineau Sarah
Published: March 2023

BACKGROUND

Facial neuromuscular retraining (fNMR) is a noninvasive physical therapy widely used to treat peripheral facial palsies. It consists of different intervention methods that aim to reduce the debilitating sequelae of the disease. Recently, the use of mirror therapy in the acute facial palsy and postsurgical rehabilitation contexts has shown promising results, suggesting its use as an adjunct to fNMR in treating patients with later stages of paralysis, such as the paretic, early, or chronic synkinetic.

OBJECTIVE

The main aim of this study is to compare the efficacy of an added mirror therapy component with fNMR in patients with peripheral facial palsy (PFP) sequelae in 3 different stages. The specific objectives of this study are to measure the effects of combined therapy compared to fNMR alone on (1) participants’ facial symmetry and synkinesis, (2) quality of life and psychological aspects of the participants, (3) motivation and treatment adherence, and (4) different stages of facial palsies.

METHODS

This study is a randomized controlled trial that compares the effect of fNMR combined with mirror therapy (experimental group: n=45) with fNMR alone (control group: n=45) in 90 patients with peripheral facial palsy presenting with sequelae 3-12 months after onset. Both groups will receive 6 months of rehabilitation training. Facial symmetry and synkinesis; participants’ quality of life; and their psychological factors, motivation, and compliance will be assessed at baseline (T0), 3 months (T1), 6 months (T2), and 12 months (T3) postintervention. Outcome measures are (1) changes in facial symmetry and synkinesis assessed with facial grading tools, (2) quality of life changes with patient questionnaires, and (3) therapy motivation with a standardized scale, as well as adherence to treatment with metadata. Changes in facial symmetry and synkinesis will be judged by 3 assessors blinded to group assignment. Mixed models and Kruskal-Wallis, chi-square, and multilevel analyses will be conducted according to the appropriate variable type.

RESULTS

Inclusion will start in 2024 and is anticipated to be completed in 2027. The 12-month follow-up will be completed with the last patient in 2028. We expect patients included in this study to experience improvement in facial symmetry, synkinesis, and quality of life, regardless of group assignments. A potential benefit of mirror therapy for facial symmetry and synkinesis could be noted for patients in the paretic phase. We hypothesize better motivation and adherence to treatment for the mirror therapy group.

CONCLUSIONS

The results of this trial may provide new guidelines for PFP rehabilitation with patients dealing with long-term sequelae. It also fills the need for robust evidence-based data in behavioral facial rehabilitation.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/47709
PLANO NACIONAL DO LIVRO E LEITURA: diretrizes para uma educação emancipatória
Authors: Da Silva Neto José Augusto , Moreira Marina , Eggert Steindel Gisela
Published: March 2023

O presente artigo tem como foco discutir o campo da educação a partir do Plano Nacional do Livro e Leitura - PNLL, como uma política emancipatória de incentivo à leitura. A discussão apresentada neste estudo crítico-reflexivo busca apresentar o plano como uma ferramenta capaz de tornar o Brasil uma sociedade leitora, na qual o exercício da prática de leitura forme sujeitos críticos e emancipados. Para auxiliar no diálogo documental e bibliográfico, contamos com as lentes teóricas de Roger Chartier (1999), Viñao Frago (2002) e Paulo Freire (1989). O texto busca instigar sobre a importância do ato de ler e o impacto das políticas públicas para o fomento à leitura. Argumentamos, ao longo do artigo que, tanto a educação quanto a cultura devem ser prioridades nas políticas de governos que prezam pela formação integral do sujeito. Concluímos que, mesmo o plano possuindo a potencialidade de se tornar uma política para a educação emancipatória, ela vem sofrendo reiterados ataques pelo atual governo ocasionando o desmantelamento da cultura e retrocessos na educação do país.
A TRAJETÓRIA DOS PROGRAMAS DE ATIVIDADES COMPLEMENTARES EM CONTRATURNO ESCOLAR NO ESTADO DO PARANÁ: (DES)CONTINUIDADES DE POLÍTICAS
Authors: Basei Andréia Paula
Published: March 2023

Este trabalho tem como objetivo compreender a trajetória dos Programas de ampliação de jornada escolar por meio de atividades complementares curriculares em contraturno escolar no estado do Paraná com foco nas políticas públicas e processos de gestão. Parte do levantamento dos programas e projetos surgidos no estado nas últimas duas décadas. A pesquisa utiliza abordagem qualitativa pelos procedimentos de pesquisa documental. Os resultados do estudo apontam que os programas e projetos de ampliação da jornada escolar não são contínuos nas suas propostas e práticas em razão de um conjunto de fatores, dentre eles: a descontinuidade de políticas públicas, a insuficiência de verbas direcionadas para a Educação e a precariedade das instalações e recursos materiais, o que contribuiu significativamente para as reconfigurações e, por vezes, interrupção dessas experiências/ações no estado. Conclui-se que o percurso traçado até então demonstra a fragilidade destas políticas educacionais e a necessidade de um planejamento em longo prazo pautado em um processo de gestão que considere e fortaleça todas as etapas do ciclo destas políticas públicas.
¿Es útil el concepto de injusticia epistémica para los procedimientos penales?
Authors: Coloma Correa Rodrigo , Rimoldi Florencia
Published: March 2023

Este texto aborda la pregunta de si el concepto de injusticia epistémica es útil para evaluar el diseño de los procedimientos penales. La irrupción de este concepto cobra especial sentido en un escenario en que juristas muestran creciente interés por la epistemología. El ejercicio de traslación de esta última hacia lo jurídico, sin embargo, ha sido incompleto, pues se ha descuidado su dimensión social y ética. Recientes precisiones de los contornos de la injusticia epistémica llevan a prestar atención a cuestiones de índole estructural. El concepto exhibe así su potencial para repensar los procedimientos penales, tanto desde su dimensión metodológica como simbólica, sobre todo si se presta atención a la noción de agencia epistémica.
On “epistemic injustice” and victimization in prisons
Authors: Stippel Jörg Alfred , Pérez Paula , Barrìa Marcelo
Published: March 2023

The article looks for reasons that explain the different results of criminal investigations conducted inside and outside prisons. We ask if and how the concept of epistemic injustice, as developed by Miranda Fricker, helps to understand those variations. The underlying hypothesis is that epistemic injustice is a symptom of a wider problem. The authors assume that the treatment of victims of violent crime inside prison has structural rather than interpersonal explanations. In a qualitative approach the study uses data from a series of semi-structured interviews with prisoners and prison officers (40 interviews in total). It explores the dynamics of the decision to report crime committed inside prisons and the role of different institutions involved in the investigation of these crimes from the perspective and experience of prisoners and prison officers. As result it is argued, that Fricker’s concept of epistemic injustice is not very helpful when it comes to understand epistemic injustice suffered by victims of violent crime inside prison. It can be better understood in the terms of epistemic oppression used by Dotson. Thus, it is not about assigning blame but how to change the underlying social relations and institutions that subordinate prisoners on epistemic grounds.
Hellenic Theology of the Epoch of High Classics
Authors: Naidysh Viacheslav M.
Published: March 2023

The conceptual basis of Hellenic theology was theoretical reflection on the essence of myth, the philosophy of mythology. Several stages can be distinguished in the history of Hellenic theology. The subject of this article is the Hellenic theology of the epoch of the high classics (Vt. half of the V century BC). The cultural roots of the High Classics go back to the ancient Enlightenment, which formed the rational attitude of the ancient consciousness to the world. The main event of the era of High Classics is the Peloponnesian War, which accelerated the crisis of the polis system, its way of life, and cultural ideals. The war led to the rupture of social ties, accelerated the individualization of the consciousness of the individual, forced to seek new social and spiritual supports. Serious shifts have taken place in the existential foundations of Hellenic religion, the understanding of man's dependence on the will of the Olympian gods and the measure of human influence on them has changed. If at the beginning of the epoch of the High Classics there was a semantic harmony of the relations between the human and the divine, then by the end of the epoch it was replaced by the confrontation and alienation of the sacred and profane. Ideas about the dependence of man on the world of the gods and the possible influence on the sacred have "blurred", have become extremely uncertain. This tendency manifested itself in various forms - in the strengthening of the influence of sophistry with its skepticism, the opposition of Chthonic and Olympic mythologies, the actualization of the motive of the birth of new gods (while the old ones do not die at all), stories about the deification of bright personalities, etc. Including in the theology of the Hellenic religion, concentrated expressed by the plots and images of the ancient drama (Sophocles, Euripides). The juxtaposition of the sacred and the profane made Hellenic religion meaningless, led it to self-denial. Under these conditions, Hellenic theology was faced with the need to transform the image of the sacred world. Firstly, by giving the otherworldly reality an abstract-conceptual transcendence. Secondly, through the ultimate generalization of mythological images of the gods, up to monotheism. These tasks were solved by the next epoch - the late classics.
Constitutional and Legal Foundations of Experimental Legal Regimes
Authors:   National Research University Higher School of Economics, Sushilnikov Ilya S.
Published: March 2023

The relevance of the study is due to the importance of the question of the legal nature of such a young institution as an experimental legal regime. The author presents theoretical developments in the ﬁeld of studying the constitutionality of experimental legal regimes, their relationship with the norms of the Constitution of Russia, dedicated to regulating the principles of a legal, democratic, federal state, support for competition, free use of one’s abilities and property for entrepreneurial and other economic activities not prohibited by law, the unity of economic space on the territory of the Russian Federation, the inadmissibility of restricting constitutional rights and citizens’ freedoms, legality and equality of all before the law. The article analyzes the relationship between the experimental legal regime and the partnership of entrepreneurs and authorities. An attempt is made to analyze the correlation between the experimental legal regime and the delegation of public powers to private individuals. The author, appealing to the judicial practice of the Constitutional Court of the Russian Federation, concludes that the experimental legal regime is based on the articles 1, 3, 8, 19, 29, 34, 55 and 75.1 of the Constitution of Russia.
On Some Problems of Applying the Principle of Farness in the Internal Activities of Business Corporations
Authors:   National Research University Higher School of Economics, Tsepov Georgy V.
Published: March 2023

Achieving farness in the internal activities of business corporation requires a combination of both organizational and contractual mechanisms, which is due to the dualistic (statutory and contractual) nature of the business corporation. Effectively applied for asset allocation the principle of proportionality cannot fully guarantee fairness in the implementation of management activities, since consolidation of corporate power is required for managerial decision-making. The exercise of power functions by majority shareholders may lead to infringement of the investment interests of minority ones. The solution to the problem is the redemption of the share by the business corporation at the request of the stockholder upon the occurrence (non-occurrence) of certain circumstances, which can be considered as the redemption of an unspeciﬁed rent in advance. Despite the existence of special rules in corporate legislation governing the repurchase of shares at the request of a shareholder in order to achieve fairness it is advisable to ﬁx the general rule on the right of a shareholder of a business corporation, taking into account the conditions provided for by law and the charter, to demand the repurchase by a business corporation of his shares in case of violation by the corporation of his reasonable investment expectations.
The Notion of Justice as a Philosophical-Legal Mythologem
Authors:   North-Western Institute of Management of the Russian Academy of National Economy and Public Administration under the President of the Russian Federation, Furman Felix P.
Published: March 2023

In the article the problematics of formation of legal values, formed in different historical stages and in different states, but having both general regularities and the features conditioned by the level of socio-political, economic, spiritualcultural, moral development, development of democratic institutions of power, civil society and the rule of law are considered. The complex understanding of the process of formation of legal life and legal ﬁeld in society and state is generalized and formulated. We analyze the existing approaches to the understanding of the process of legal regulation and their evaluation in the general system of legal values through the prism of such philosophical and legal phenomenon as justice.
Proyecto educativo para la nueva ruralidad: proyecto educativo de la escuela de ciencias agrícolas pecuarias y del medio ambiente - UNAD
Authors: Santacoloma Varón Luz Elena
Published: March 2023

El presente documento consta de varios capítulos. El primero de ellos hace una contextualización institucional en la que se destaca el marco normativo más relevante y se presenta una breve descripción de su historicidad, en la que se aprecia el avance en cuanto a la presencia de la universidad en todas las regiones del país a través del tiempo. Así mismo, expone los "momentos" que han marcado hitos en el devenir de la Escuela de Ciencias Agrícolas, Pecuarias y del Medio Ambiente, ECAPMA, y sus desarrollos en cuanto a la oferta y la diversificación de programas académicos. Ofrece además un detallado análisis acerca de los referentes en materia de política para los programas de la ECAPMA. El segundo capítulo expone los fundamentos conceptuales y epistemológicos que sustentan los desarrollos de las ciencias agrarias y ambientales en la construcción de conocimiento. Hace evidente la alta complejidad y la necesidad de establecer diálogos permanentes entre diferentes disciplinas, tanto exactas como naturales y (o) sociales, y hace hincapié en la necesidad de procurar enfoques interdisciplinares para el abordaje de las problemáticas agroalimentarias y ambientales. También presenta un recorrido por las principales escuelas de pensamiento en torno a la producción de alimentos, para culminar con la presentación de un panorama sobre las perspectivas de la nueva ruralidad como enfoque para alcanzar un desarrollo rural integral. El tercer capítulo se concentra en aspectos curriculares y pedagógicos, y en él se hace énfasis en la estructuración curricular por categorías de problemas o núcleos problémicos. Del mismo modo, se indican y describen las estrategias pedagógicas y didácticas más utilizadas en los programas de grado y posgrado, notables por el nivel de innovación y el uso de medios y mediaciones. En el cuarto capítulo se presenta una reseña de cada uno de los programas que integran las cadenas de formación y la estructura organizacional como elemento que hace posible el desarrollo y el avance de la ECAPMA. El documento se propone como guía importante para los estudiantes de la Escuela, ya que recoge el conjunto de normas, principios y conceptos que definen el modelo educativo, así como las acciones y los instrumentos que lo hacen operativo.
Is Smoke the Signal for Surgery? : Should the Moyamoya Syndrome “Puff of Smoke” trigger cerebral revascularization surgery in children with sickle cell disease?
Authors: Hsu Lewis
Published: March 2023

Stroke in Sickle Cell Revascularization Surgery Retrospective Study
(SiSCRS) in this issue reports retrospective data from 15 medical
centers to examine the benefit of cerebral revascularization surgery
(CRS) in children with sickle cell disease (SCD) who also have Moyamoya
Syndrome (SCD-MMS). The American Society of Hematology guidelines
“suggests evaluation for revascularization surgery in addition to
regular blood transfusion” for treating SCD-MMS combined with a history
of stroke or transient ischemic attack but categorizes this as a
“conditional recommendation based on very low certainty in the evidence
about effects”. The research presented in this article is aimed at
reducing the uncertainty surrounding revascularization surgery as a
treatment using retrospective data from 15 medical centers with
expertise in CRS for SCD-MMS. Even with the 78 children with CRS
(Surgery group) and 63 children in the non-surgery (Conservative group),
the differences between the two groups had mixed statistical
significance in multivariate analyses. SiSCRS is an important
retrospective analysis but must be interpreted with caution. The benefit
of CRS attains statistical significance only in some of the comparisons.
The rate of stroke in pediatric SCD decreases with age, creating a bias
in favor of the older group (i.e., the Surgery Group) to have fewer
CVEs, The additional role of aspirin and the bias of patient selection
for surgery also weaken the ability to make definitive statements. The
SiSCRS results suggest a likely retrospective benefit of CRS, but the
benefit must be demonstrated with more rigorous studies in the future.
Streptococcus suis causes bacterial meningitis with hearing loss in patients without direct exposure to pigs in a regional pork industry territory
Authors: Kim Joong-Goo , Seong Gil Myeong , Kim Young Ree , Heo Sang Taek , Yoo Jeong Rae
Published: March 2023

Streptococcus suis (S. suis) is an emerging zoonotic pathogen that causes bacterial meningitis in humans. S. suis is an encapsulated gram-positive facultative anaerobic bacterium and is an important pathogen in pigs. This infectious disease usually manifests in humans as meningitis, endocarditis, septicemia, and arthritis. Most cases originate in Southeast Asia, and human S. suis infections are often reported in countries with a high density of pigs. Meningitis is a common clinical manifestation of S. suis infection. Moreover, hearing loss is a common complication that can be bilateral, profound, and/or permanent. This report presents two cases of bacterial meningitis and hearing loss caused by S. suis in patients without a history of direct exposure to pigs in an intensive pork industry region.
Are interventions outside the workplace to reduce sedentary behavior in adults effective? - A Cochrane Review summary with commentary
Authors: Levack William
Published: March 2023

This summary is based on a Cochrane Review previously published in the Cochrane Database of Systematic Reviews 2020, Issue 7, Art. No.: CD012554, DOI: 10.1002/14651858.CD012554.pub2 (see www.cochranelibrary.com for information). Cochrane Reviews are regularly updated as new evidence emerges and in response to feedback, and Cochrane Database of Systematic Reviews should be consulted for the most recent version of the review.
* The views expressed in the summary with commentary are those of the Cochrane Corner author (different than the original Cochrane Review authors) and do not represent the Cochrane Library or Journal of Rehabilitation Medicine.
Isolation and Characterization of Dermatophytes from Students Bathing Places
Authors: ME Ebere
Published: March 2023

Background: Dermatophyte comprises of a vast range of filamentous pathogenic fungi that infect keratinous tissues of skin (the stratum corneum layer), hair, and nail in humans and animals via their keratinase enzymes which are capable of causing superficial infections. Aim: This study aimed to isolate and characterized dermatophytes isolated from students bathing places. Methodology: Four sampling sites were chosen from both male and female students bathing places; the floor, walls, sinks and door handles. Three hundred samples were collected and cultured on sterile plates containing Potato dextrose agar using spread plate method. The plates were incubated at 350C for 72 hours. Results: Out of three hundred samples collected from the various sampling sites, a total of four hundred and ten fungi were isolated, 286 (70%) were dermatophytes belonging to three genera (Trichophyton, Microsporum and Epidermorphyton) while124 (30%) were non dermatophytes. The female bathing places yielded 167(58%) and 48(39%) dermatophytes and Candida species respectively higher than male counterparts which yielded 119 (42%) dermatophytes without any species of Candida. There was no significant difference between the isolates from female and male bathrooms P ≥ 0.05. Conclusion: Hence the students bathing places were found to be rich in pathogenic and potentially pathogenic fungi and need thorough disinfectants to avoid dermatophytes infections’ like Tinea pedis, Tinea corporis Tinea capitis and Tinea cruris.
The Genues Trichoderma: Ecologicological Diversity, Taxonomic Classification and Its Agricultural, Human Health, Industrial and Environmental Applications
Authors: T Abena
Published: March 2023

The genus Trichoderma is a diverse group of free-living fungi in the family Hypocreaceae (class Ascomycetes), that are living at different ecosystems in a wide range of climatic zones and that can be found all over the globe. The common ecological nich of the genus Trichoderma includes Natural soils, Decaying wood, Agricultural Habitats, Endophytes and mushroom related substrates. Trichoderma classified base on their morphological and cultural characteristics, conidiophore structure as well as the size of conidia. Now adays, molecularmethods including DNA fingerprinting and sequence analysis of multiple genes (ITS1- 5.8 rDNA-ITS2 and genes encoding translation-elongation factor 1-alpha (tef1) as well as some specific molecular databases have been used for taxonomic classification of this fungi. Trichodermahave been used agriculture biological control of plant diseases and as plant growth promoter, in industry as sources of cellulolytic and hemicellulolytic enzymes used in different industries, in human health producer of secondary metabolites that have clinical importance and in enviromt they are as a potential biodegrader of toxic compounds and soil bioremediation.Therefore, this review article presented the ecological diversiy, taxonomic classification and application of genus Trichoderma.
The Effect of Math Anxiety on Boarding School Students' Mathematics Learning Outcomes during Online Learning
Authors: Omika Hefri Asra
Published: March 2023

Currently, students face a lack of references to math anxiety in the context of boarding school education and online learning during the COVID-19 pandemic. This study aims to analyzes the effect of math anxiety on mathematics learning outcomes in boarding school students during online learning during the COVID-19 pandemic. The sample of this research consisted of 182 class XII students in boarding schools. Sample selection uses a simple random sampling technique. The instrument used was a math anxiety questionnaire from Cooke et al. and a mathematics learning outcome document. The results of the instrument reliability test with a Cronbach alpha value of 0.968. Data analysis used descriptive analysis, linear regression test, and independent-sample t-test. The results of this study indicate that (1) the level of math anxiety in boarding schools is in a low category, (2) math anxiety has a significant effect on student learning outcomes based on a linear regression significance value of 0.02 which is a smaller than 0.05, and (3) there is a significant difference between the math anxiety levels of male and female students, where female students have higher math anxiety levels.
Ecolinguistic-Based English for Computer Learning Tools to Develop Students’ Creative Thinking Ability
Authors: Afrianti Indah , Supriyaddin  , Nurhasanah Enung , Asmedy  , Wahyuni Nur
Published: March 2023

Learning English is one of the important fundamental aspects that students must master from the lexicon/vocabulary learning process. Currently, lecturers only focus on giving assignments on test questions in general English books. This results in students not being confident in speaking English because they do not have a large collection of vocabulary. This study aims to produce an Ecolinguistic-based English for Computer learning tool. This research method is research development using the ADDIE model which consists of several steps, namely analysis, design, development, implementation, and evaluation. The subjects in this study consisted of 3 expert validation and 30 students in the information technology study program STKIP Yapis Dompu. The research instruments used in this research are Learning Device Validation Sheet, Learning Implementation Plan, Worksheet, Response Questionnaire, and Learning Outcome Test. The data analysis techniques in this study were expert validation analysis, test data analysis, and test analysis of learning outcomes. The result of this study shows learning tools of the material are presented well, the language used is easy to understand, and the questions given can be done by students. Textbooks are also effective in increasing the achievement of student learning outcomes because they are actively involved in finding material, finding relationships between materials, and being able to apply their knowledge so that students will be able to construct knowledge gained from their experiences. The resulting product is in the form of English course textbooks for students in the Information Technology Education Study Program.
Dynamical behavior of predator–prey model with non-smooth prey harvesting
Authors:   Applied Mathematics Laboratory, Faculty of Exact Sciences, University of Bejaia, Algeria, Meziani T. , Mohdeb N. ,   Applied Mathematics Laboratory, Faculty of Exact Sciences, University of Bejaia, Algeria
Published: March 2023

The objective of the current paper is to investigate the dynamics of a new predator–prey model, where the prey species obeys the law of logistic growth and is subjected to a non-smooth switched harvest: when the density of the prey is below a switched value, the harvest has a linear rate. Otherwise, the harvesting rate is constant. The equilibria of the proposed system are described, and the boundedness of its solutions is examined. We discuss the existence of periodic solutions; we show the appearance of two limit cycles, an unstable inner limit cycle and a stable outer one. As the values of the model parameters vary, several kinds of bifurcation for the model are detected, such as transcritical, saddle–node, and Hopf bifurcations. Finally, some numerical examples of the model are performed to confirm the theoretical results obtained.
Fractional derivative model for tumor cells and immune system competition
Authors:   Laboratory of Mathematics, Computer science and Applications, Faculty of Sciences and Techniques Mohammedia, University Hassan-II Casablanca, Mohammedia, Morocco, Elkaf M. , Allali K. ,   Laboratory of Mathematics, Computer science and Applications, Faculty of Sciences and Techniques Mohammedia, University Hassan-II Casablanca, Mohammedia, Morocco
Published: March 2023

Modeling a dynamics of complex biologic disease such as cancer still present a complex dealing. So, we try in our case to study it by considering the system of normal cells, tumor cells and immune response as mathematical variables structured in fractional-order derivatives equations which express the dynamics of cancer's evolution under immunity of the body. We will analyze the stability of the formulated system at different equilibrium points. Numerical simulations are carried out to get more helpful and specific outcome about the variations of the cancer's dynamics.
The cultural content and intercultural communicative competence in the global and local textbooks used in Indonesian EFL classes
Authors: Agustina Noni , Kencana Nila
Published: March 2023

A number of studies on the cultural content represented in local or global textbooks have increasingly been investigated. However, it is scanty research comparing local and global textbooks. This study aims to examine two textbooks determined by the Indonesian Ministry of Education and Culture, a global textbook entitled English in Mind for schools implementing a new curriculum called Merdeka curriculum and a local textbook, When English Rings a Bell, for schools that have not applied it. The study employed content analysis as a research design. The results show that the global textbook provides more on target culture, but the local textbook highly emphasizes source culture and neglects international cultures. In addition, the global textbook concerns social and environmental themes, while the local textbook focuses more on religion/humanities/art and personal theme. Further, the global textbook does not accommodate adequate intercultural communicative competence, which was absent in the local textbook. The imbalanced cultural representations in those textbooks affect students’ intercultural competence. The study suggests the practical implications of providing students with sufficient references to the target, source, and international cultures to promote their intercultural competence.
PERBANDINGAN KINERJA METODE AVERAGE LINKAGE DAN WARD DALAM PENGELOMPOKAN TINGKAT KESEJAHTERAAN MASYARAKAT PROVINSI SUMATERA BARAT MENURUT KABUPATEN/KOTA TAHUN 2021
Authors: Ramadani Riska , Salma Admi
Published: March 2023

Welfare in West Sumatra Province is still an important problem that is being faced by the government and also the whole community in 2021. The government is still trying to improve performance the welfare of the community from all aspects. It is necessary to grouping the level of community welfare in the Province of West Sumatra by Regency/City using the average linkage and ward methods. The results of the cluster analysis obtained by both methods show that the clusters formed are the same. Consists of 3 clusters, namely cluster 1 with a low level of welfare, cluster 2 with a medium level of welfare and cluster 3 with a high level of welfare. Of the two methods, the average linkage method is better in grouping the levels of welfare based on validity because it has a large Dunn Index value and a small Connectivity value compared to the ward method.
Analisis Pengendalian Persedaa Kayu dengan Metode Economic Order Quantity (EOQ) di PT. Sumber Tata Citra Mandiri (STCM)
Authors: Nurhalizah Mega , Helma Helma
Published: March 2023

Inventory control of raw materials is one of the main factors that must be carried out by a company. The main goal of a company is to get a high profit by minimizing the cost of the production process. To obtain high profits, a company will plan and control raw materials. PT. Sumber Tata Citra Mandiri is a manufacturing company that processes wood into plywood. To overcome the problem of raw material supply, the purpose of this research is to optimize the control of wood control by using the Economic Order Quantity (EOQ) method.This research is an applied research. The variables in this study are the use of raw materials, forecasting of raw material inventory, raw material inventory and EOQ consisting of storage costs, ordering costs, reorder points, safety stock. The data to be calculated is the inventory data of the main raw material, namely wood. The data analysis method used is Economic Order Quantity, Safety Stock, Reorder Point and Total Inventory Cost.Based on the results of the study, , it was found that the inventory each  month has increased and decreased. The optimal supply of wood in 2021 using the EOQ method is 3401.34 m3 with a frequency of ordering wood 7 times in one period (1 year), safety stock of 865.70 m3, and the company must place a reorder point at an inventory level of 1708 ,83 m3. According to the company's policy, the total cost of  timber supplies is higher, which is Rp. 789,593,600.00 while with the EOQ method of Rp. 544,214,614.00 so that it can be done as much as Rp. 245,378,986.00 of the cost of timber supplies according to PT.Sumber Tata Citra Mandiri
Analisis Cluster Hierarki Metode Single Linkage Pada Kabupaten/Kota di Provinsi Sumatera Barat Berdasarkan Indikator Kesehatan
Authors: Thamrin Diah Rahmahadi , Murni Dewi
Published: March 2023

Health indicators are variables that are needed as a benchmark to determine conditions and changes in the health sector. Health indicators are needed by the government to plan development in the health sector in order to achieve optimal results in accordance with the conditions of each region. The purpose of this study is to group districts/cities in West Sumatra Province based on health indicators in 2020 and interpret the characteristics of each cluster that has been formed by using single linkage method hierarchical cluster analysis. The results of the grouping are divided into 2 clusters, cluster 1 consists of one district, namely the Mentawai Islands Regency, including areas with high health levels. Cluster 2 consists of 18 regencies/cities namely Pesisir Selatan Regency, Agam Regency, Solok Regency, Tanah Datar Regency, Bukittinggi City, Payakumbuh City, Sijunjung Regency, Fifty Cities Regency, Padang City, Sawahlunto City, Dharmasraya Regency, Pariaman City, Regency South Solok, Padang Pariaman Regency, West Pasaman Regency, Solok City, Pasaman Regency, and Padang Panjang City are areas with low health levels.
Preferensi Mahasiswa UNP Terhadap Tempat Kos di kec. Padang Utara pada Masa Pandemi (Covid-19) dengan Menggunakan Analisis Konjoin
Authors: Bartasari Lidia , Arnellis Arnellis
Published: March 2023

Indekos merupakan kebutuhan primer oleh mahasiswa yang merantau. Setiap mahasiswa memiliki preferensi yang berbeda dalam menenentukan tempat tinggal atau indekos. Penelitian ini bertujuan untuk menentukan kombinasi level fungsional dari level preferensi mahasiswa UNP dalam memilih indekos di Kecamatan Padang Utara. Atribut yang dipakai dalam penelitian ini yaitu jarak indekos, harga sewa, dan fasilitas indekos. Pengambilan sampel dalam jurnal ini menggunakan metode purpose-driven sampling. Teknikanalisis data yang digunakan dalam penelitian ini adalah analisis konjoin. Dari hasil penelitian diperoleh kombinasi level atribut .paling disukai mahasiswa UNP..dalam memilih indekos adalah jarak kos <1 km, harga sewa kos Rp.200.000-Rp.350.000, dan fasilitas kos yang mengutamakan Wi-Fi. Sedangkan kombinasi level atribut yang tidak disukai  mahasiswa UNP dalam memilih indekos adalah jarak kos >3 Km, harga sewa kos >Rp.500.000, dan fasilitas kos tidak ada fasilitas. Atribut pa1ing penting bagi mahasiswa UNP dalam pemilihan sebuah indekos adalah atribut fasilitas kos karna memiliki nilai utility tertinggi yaitu.sebesar 39,4%.
Cadangan Premi Asuransi Jiwa Berjangka dan Asuransi Jiwa Dwiguna Menggunakan Metode Premium Sufficiency
Authors: Widuri Gusvira , Sari Devni Prima
Published: March 2023

Asuransi jiwa adalah pembayaran uang yang diberikan atas kematian tertanggung terhadap ahli waris sesuai ketentuan polis. Jenis asuransi jiwa ada empat, diantaranya asuransi jiwa seumur hidup, asuransi jiwa berjangka, asuransi jiwa dwiguna murni, dan asuransi jiwa dwiguna. Sejumlah santunan yang didapatkan tergantung besarnya premi yang dibayarkan. Manfaat dari pembayaran premi digunakan untuk persiapan pembayaran uang pertanggungan. Cadangan premi ialah dana cadangan yang harus disiapkan perusahaan agar dapat menutupi klaim peserta asuransi yang terjadi kapanpun. Terdapat beberapa cara dalam memperhitungkan cadangan premi salah satu yang dapat digunakan yaitu metode premium sufficiency. Cadangan premium sufficiency menyertakan biaya awal dan biaya pemeliharaan setelah masa asuransi dalam prhitungannya. Perhitungan cadangan metode premium sufficiency menggunakan premi kotor dapat memberikan secara rinci seluruh biaya yang diperlukan beserta besarnya cadangan yang harus disediakan perusahaan asuransi.
Model Matematika Dinamika Kemiskinan Dengan Pengaruh Konsumsi Alkohol
Authors: Miati Isra , Subhan Muhammad
Published: March 2023

Masalah kemiskinan merupakan tantangan utama pembangunan di tingkat global. Banyak strategi yang dilakukan untuk mengatasi permasalahan kemiskinan ini. Namun, dalam mengatasi permasalahan ini muncul suatu persoalan yang umum di kalangan keluarga miskin yaitu terkait dengan pengonsumsi alkohol. Akibat dari mengonsumsi alkohol secara berlebihan akan membuat individu  menjadi ketergantungan alkohol dan pecandu alkohol. Tujuan dalam penelitian adalah untuk dapat melihat suatu model matematika dan analisis yang diperoleh. Untuk metode yang dilakukan di dalam penelitian adalah dengan menggunakan metode deskriptif. Berdasarkan analisis yang telah dilakukan diperoleh satu titik tetap bebas. Selanjutnya akan ditentukan kestabilan dari titik tetap, yang mana menunjukkan bahwa titik tetap bebasnya bersifat stabil jika γδ+γμ+μσ+μ^2+μ_1 σ+μ_1 δ+μ_1 μ>βσ+βδ+βμ. Hasil simulasi untuk titik tetap bebas menunjukkan bahwa pada waktu tertentu masalah akan menghilang jika laju individu dari kelompok miskin yang tidak kecanduan alkohol menjadi miskin kecanduan alkohol (β) diperkecil dan laju individu kelompok miskin kecanduan alkohol yang di rehabilitasi (γ) diperbesar.
Prediksi Jumlah Pengunjung Perpustakaan Daerah Kabupaten Batang dengan Menggunakan Metode Fuzzy Time Series Chen-Hsu
Authors: Rahmawati Rahmawati , Putra M. Rafly Ramaesa , Muttakin Fitriani
Published: March 2023

Perpustakaan kabupaten batang merupakan salah satu tempat yang sering di kunjungi oleh masyarakat sekitar. Analisis pola kunjungan perpustakaan dan prediksi jumlah pengunjung sangat penting untuk dilakukan, karena hal ini merupakan dasar dalam perencanaan kebijakan yang efektif bagi para pemangku kepentingan untuk memberikan rasa nyaman bagi para pustakawan. Tujuan penelitian ini adalah untuk meramalkan jumlah pengunjung Perpustakaan Daerah Kabupaten Batang pada tahun 2023. Metode Fuzzy Time Series Chen-Hsu digunakan dalam penelitian ini karena memberikan nilai MAPE yang dapat memberikan bukti keakuratan yang lebih mudah dibandingkan dengan metode lainnya. Hasil penelitian menunjukkan bahwa pengunjung perpustakaan daerah Kabupaten Batang dari tahun 2018-2022, terjadi penurunan pada tahun 2021  hingga 2022, dan menurut hasil peramalan menggunakan metode Fuzzy Time Series Chen-Hsu pengunjung perpustakaan Daerah Kabupaten Batang tidak mengalami perubahan dari tahun sebelumnya dan memiliki rata-rata MAPE 15,56%, sehingga tingkat akurasinya adalah baik.
Reflection on the Social Construction of Technology in the Philosophy of Technology
Authors:   The Korean Association of Practical Arts Education, Lee Choon-Sig
Published: March 2023

Technological determinism initially emerged in the relationship between technology and society. In the environment surrounding technology and society, technology determinism and social construction of technology (SCOT) have a tense relationship. This study aims to reveal the characteristics of SCOT by exploring and reflecting on the substantive debates and criticisms surrounding the social constructionism of technology, which is opposed to technological determinism in terms of the philosophy of technology. It is intended to substitute for the conclusion of the study by suggesting the implications obtained through reflection on SCOT. First, driving technological development in SCOT is achieved through consensus between social groups and technology developers. In the process of technological development, conflicts arise among social groups due to different problems and solutions with respect to technology, and the form of the technological artifact that has reached an agreement is finally selected. Second, technological flexibility or interpretative flexibility can solve a problem in various technical ways in SCOT. This variety of flexibility appears as a difference of interpretation and conflict between the social groups surrounding technology. Third, in SCOT, the technology frame greatly affects the artifacts. The function of the description frame differentiates it from most other concepts and is intended to be applied to the interaction of various actors. Fourth, for a specific technology to develop from the SCOT perspective, it has momentum through the consolidation of the technology system. A technological system is composed of physical artifacts, organizations, science bases, legal devices, and natural resources, with each element contributing to the overall goal of the system by interacting with other elements.Fifth, in SCOT. Finally, the main criticism of SCOT is that researchers’ methodologies are formal, they focus on the early stage of the emergence of technology, there is indifference to the influence of technology, and the social structures and power relations accompanying technological change are ignored.
Congenital renal hypoplasia and contralateral kidney failure in a giant otter (Pteronura brasiliensis) ex situ in Southeastern Brazil
Authors:   Instituto Biopesca, Ribeiro Vanessa , Kokubun Hanna ,   Faculdade de Educação e Arte, Universidade do Vale do Paraíba, Riva Henrique ,   Fundación Botánica y Zoológica de Barranquilla, Nemer Viviane ,   Universidade Federal do Rio Grande do Sul, Bianchi Matheus ,   Universidade Federal do Rio Grande do Sul, da Costa André ,   Parque Zoológico Municipal “Quinzinho de Barros”, Teixeira Rodrigo ,   Parque Zoológico Municipal “Quinzinho de Barros”
Published: March 2023

Renal hypoplasia is incomplete development of the kidneys, in which fewer than normal numbers of nephrons are present at birth. This report is the first of these conditions in mustelids. A female adult giant otter (Pteronura brasiliensis), ex situ, presented clinically an unusual behavior with prostration, anorexia, hiding in the shelter, ataxia, paraparesis, and death in a clinical course of one day. At the postmortem exam, the left kidney was markedly enlarged and pale and the right kidney was severely reduced and had mild to moderate capsular thickening. Histologically, the left kidney had mineralization, proliferation of fibrous connective tissue and a mild neutrophilic infiltrate. The right kidney presented a reduced number of glomeruli, tubular atrophy and an increase in fibrous connective tissue, which were findings compatible with congenital kidney hypoplasia. Due the clinical condition of the animal, gross and microscopic findings, the cause of death was established as kidney failure induced by renal hypoplasia.
Vitamin A deficiency in peafowl with secondary visceral urate deposition
Authors:   1Texas A&M Veterinary Medical Diagnostic Laboratory (TVMDL),, Edwards Erin , Rice Laura ,   1Texas A&M Veterinary Medical Diagnostic Laboratory (TVMDL),
Published: March 2023

Clinical History: In a flock of approximately 180 peafowl, several were showing signs of a possible upper respiratory infection and had mouth gaping per the owner. They were also reported to be lethargic, to have excessive phlegm or mucus in the mouths, had trouble swallowing, and were losing weight. They were being treated with Baytril and Metronidazole with no improvement. Approximately eight had died. Five peafowl were submitted for necropsy and diagnostic work-up, including three peahens and two peacocks. Gross Findings: In all five peafowl, the oral cavity contained excess mucus. The oral, crop, and esophageal mucosa had disseminated, smooth, raised, round nodules with a central pore. The proximal esophagus was the most severely affected site. The nodules measured on average ~2 mm in diameter. Upon squeezing some of these nodules, pale tan, caseous material could be expressed. In all five peafowl, the heart was diffusely coated by abundant white, chalky, urate material. Similar though lesser amounts of urates partially coated the surface of the liver and other coelomic membranes. In one peahen, the ureters were multifocally distended and contained consolidated accumulations of tan to pale yellow, caseous material. The kidneys in this bird were pale.