bluuebunny/crossref_metadata_2025 huggingface dataset:
Penerapan Pentingnya Perilaku Hidup Bersih dan Sehat Di SDN 1 Sucopangepok dan SDN 2 Sucopangepok
Authors: Siswanto Edhi , Setiadi Ahmad Widarta
Published: April 2022

Perilaku hidup bersih dan sehat (PHBS) adalah semua perilaku kesehatan yang dilakukan atas kesadaran, sehingga anggota keluarga dapat menolong dirinya  sendiri di bidang kesehatan dan berperan aktif dalam kegiatan – kegiatan kesehatan di masyarakat. PHBS yang di lakukan mahasiswa KKN Universitas Muhammadiyah Jember yaitu sosialisasi tentang tata cara mencuci tangan yang baik dan benar dengan tujuan memberikan pemahaman tentang bagaimana pola hidup sehat di mulai dari usia dini. Setiap anak di anjurkan untuk melaksanakan semua perilaku kesehatan, dengan begitu resiko terjadinya penyakit bias di minimalisir. PHBS di sekolah adalah upaya untuk memberdayakan peserta didik, guru, dan masyarakat lingkungan sekolah agar tau dan mampu mempraktikan PHBS dan berperan aktif dalam mewujudkan sekolah sehat. Perilaku hidup bersih dan sehat juga merupakan sekumpulan perilaku yang di praktikan oleh peserta didik, guru, dan masyarakat lingkungan sekolah atas dasar kesadaran sebagai hasil pembelajaran, sehingga secara mandiri mampu mencegah penyakit, meningkatkan kesehatan, serta berperan aktif dalam mewujudkan lingkungan sehat
Connecting Title I Schools and the Pre-Brown Era: Do Contemporary School Principals Espouse Pre-Brown Educational Beliefs?
Authors: Croft Sheryl , Buckman David
Published: April 2022

The purpose of this study was to determine what school and principal characteristics influence the alignment of contemporary leaders’ beliefs with African American principals’ beliefs working during the pre-Brown v. Board era. Using OLS multiple regression on a sample of Georgia school principals, the study found a statistically significant relationship (b=.252, p ≤ 0.05) supporting that principals who worked in Title I schools encompassed higher levels of pre-Brown beliefs than principals of non-Title I schools. This finding indicates that leaders of Title I schools, much like the leaders who led the segregated schools for people of color during the pre-Brown era, instill a set of values that among other attributes are student-centered, optimistic, and dedicated which impacts school culture and potentially positive student outcomes.
The Strategy of English to Chinese Translation of Advertisements from the Perspective of Nida's Functional Equivalence Theory
Authors: Cai Lili
Published: April 2022

With the rapid development of economic globalization, advertising has become one of the most significant ways in transnational marketing. The quality of advertisement translation will directly affect the sale of products. On the basis of a review of advertisements, this thesis intends to explore the methods of English to Chinese advertisement translation under the guidance of Nida's functional equivalence theory.
Competencias del docente actual
Authors: Peña Chamorro Libardo
Published: April 2022

En el libro que Ud. Tiene en sus manos con el nombre de COMPETECIAS DEL DOCENTE ACTUAL, aportan filósofos como Protágoras, Platón, Aristóteles y luego se realiza una aproximación al concepto de competencias para definir el fundamento pedagógico y sociológico de las competencias generales. Además se estudian los aportes que hace el currículo y la didáctica; luego de lo cual se analizan algunas diferenciaciones entre competencias, habilidades y destrezas, para describir las competencias fundamentales del docente, su formación y sus retos. Enseguida encontrará amable lector las conceptualizaciones y el significado de tensión entre técnica y práctica, entre lo objetivo y subjetivo, entre lo que se piensa y lo que se hace, para describir el significado de las competencias instrumentales, cognitivas, sociales, axiológicas, epistemológicas, comunicativas, productivas, socio-políticas, hermenéuticas, científico, tecnológicas, critico-sociales, vocacionales, valorativas, para pasar al tema de la capacitación docente y sus ámbitos, programas de competencias y sus ambientes, se describe la formación por competencias, el plan de formación para finalizar haciendo un resumen del capítulo. Una vez finalizado lo anterior se describe el análisis de los saberes que debe manejar un docente en la actualidad: el saber ser, el saber conocer y el saber hacer. El saber ser se relaciona con la sinergia que debe establecer el maestro consigo mismo en franca armonía con los valores, luego se pasa a describir las competencias emocionales que debe manejar un docente actual y se continua analizando los procesos como la atención, la adquisición, personalización, recuperación, cooperación, transferencia, actuación, evaluación y sus tres formas: autovaloración, hetereovaloración y covaloración.
Asambleas productivas y soluciones estructurales para la crisis en Ecuador
Authors: Paguay Chávez Félix Wilmer , Viveros Almeida Luis Homero , Montenegro Obando Blanca Liliana , Realpe Cabrera Iván Alírio , Terán Rosero Gustavo Javier , León Ibarra Rubén Darío , De la Torre Fernando , Pazmiño Vásquez Carlos Eduardo
Published: April 2022

La presente obra constituye el resultado de un conjunto de acciones desarrolladas a nivel nacional sobre la base de las asambleas populares productivas promovidas por la Superintendencia de Control del Poder del Mercado (SCPM), las cuales han surgido como mecanismo para fortalecer la participación mediante la promoción de espacios de inclusión económica de nuevos actores en el mercado, identificando las barreras de entrada generadas por el mercado y las instituciones públicas y así sentar las bases para alcanzar un mercado transparente, justo y equitativo. Los objetivos que se plantea la publicación del libro “Asambleas productivas y soluciones estructurales para la crisis en el Ecuador” se enmarcan en la posibilidad de compartir los resultados de los espacios de diálogo y socialización creados por la SCPM con miras a preparar a los actores económicos.
Klasifikasi Hewan Mamalia Berdasarkan Bentuk Wajah Menggunakan Fitur Histogram of Oriented dan Metode Support Vector Machine
Authors: Al Rivan Muhammad Ezar , Arman Molavi , Irsyad Hafiz , Prameswara Reynald Dwika
Published: April 2022

Mammals have several characteristics that can be distinguished, such as footprints, voice, and face shape. Mammals can be recognized. To classify the face shape of mammals, the Histogram of Oriented Gradients (HOG) and Support Vector Machine (SVM) methods can be used. This study uses the LHI-Animal-Faces dataset which is taken as many as 15 species of mammals, where each type of mammal is selected 60 images and resized to 150x150 pixels. The image is converted into a grayscale image for the HOG feature extraction process. Furthermore, the classification process uses SVM. The kernels used are Linear, Polynomial, and Gaussian kernels. The testing process uses K-Fold Cross Validation. The folds used are 3-fold, 4-fold, 5-fold, 6-fold, and 10-fold. The performance of the HOG feature and the SVM method that gives the best results is the Linear kernel using 10-fold with an accuracy value of 96.55%, precision of 77.92%, and recall of 74.11%. The sequence of kernels that give the best results in this test is the Linear kernel, Polynomial kernel, and Gaussian kernel.
Implementasi Intrusion Prevention System (IPS) OSSEC dan Honeypot Cowrie
Authors: Susanti Risa Eri , Muhammad Arif Wirawan , Prabowo Wahyu Adi
Published: April 2022

Perkembangan teknologi yang semakin canggih ini banyak digunakan sebagai tindak kejahatan, seperti pencurian data, pemalsuan data hingga merusak sistem maupun jaringan. Dengan adanya permasalahan tersebut, dibutuhkan sistem pengamanan berlapis untuk menjaga integritas data maupun sistem agar tetap utuh. Pengamanan sistem OSSEC yang diintegrasikan dengan honeypot cowrie ini bertujuan untuk menekan waktu penyerangan, dimana pada sistem ini saling bekerja sama untuk memberikan log untuk melakukan tindakan terhadap penyerang. OSSEC bekerja layaknya firewall yang dapat melakukan allow maupun block. Sedangkan honeypot cowrie ini bekerja layaknya server asli untuk menjebak penyerang seolah-olah berhasil melakukan penyerangan. Dalam penelitian ini, sistem yang telah dirancang agar dapat menangani adanya serangan seperti Port Scanning, SSH brute force, Man in The Middle (MITM) attack, dan Distributed Denial of Service (DDoS). Dari hasil perbandingan serangan dengan confusion matrix ini OSSEC yang diintegrasikan dengan honeypot cowrie memiliki tingkat akurasi yang besar terhadap serangan DDoS, Berdasarkan log, akurasi deteksi dapat mencapai persentase 100%.
Prisoner and Goods Control System Design Evidence Using MVC and UAT Models at the Provincial National Narcotics Agency
Authors: Rizan Okkita , Hamidah Hamidah , Wahyuningsih Delpiah , Sarwindah Sarwindah
Published: April 2022

In Indonesia, there is a special agency tasked with dealing with the misuse of prohibited goods, namely the National Narcotics Agency, abbreviated as BNN. Apart from being at the center, BNN is also at the provincial level. At the National Narcotics Agency, there is a section or section that has a special function to manage the supervision of prisoners and evidence in the form of narcotics. The problem is, the administrative process is still irregular, archives are difficult to find, and several other important things, which are certainly very influential for the next process and follow-up. This study aims to help design a system that can manage the process of monitoring prisoners and evidence. For the research method, the author uses a prototype model, Model View Controller (MVC), and User Acceptance Test (UAT). The results showed that the system can work well in assisting the process of monitoring prisoners and evidence with a percentage of 54.29% strongly agree and 64.00% agree with the developed system model.
Seleksi Peserta Didik Baru Dengan Metode Additive Ratio Assessment (ARAS)
Authors: Wahyuningsih Delpiah , Hamidah Hamidah , Anisah Anisah , Irawan Devi , Rizan Okkita , Kirana Chandra
Published: April 2022

Penerimaan peserta didik baru merupakan kegiatan penerimaan calon siswa baru di sekolah pada awal semester yang sering disingkat dengan PPDB. PPDB pada sekolah tingkat pratama dimana kriteria masuk SMP Negeri menyesuaikan kriteria yang ada di dinas pendidikan. Kriteria yang digunakan yaitu nilai matematika, bahasa indonesia, IPA, sertifikat akademik maupun non akademik mulai dari sertifikat tingkat Kabupaten/kota, sertifikat Provinsi, sertifikat Regional, sertifikat Nasional dan Juara Umum pada sekolah dasar. Penyeleksian menggunakan metode additive ratio assessment (ARAS) untuk menghindari kecurangan dalam PPDB. Hasil uji coba pada penelitian ini menggunakan 10 data dengan perankingan tertinggi yaitu A1 dengan nilai tertinggi 0,790 bernama Sandri Pratama.
External Audit Process Failures: Unethical Practices and Business Demise
Authors: Nnah Ugoani John Nkeobuna , Iyi Ibeenwo Grace
Published: April 2022

The primary aim of external auditing is for the independent auditor to comply with authoritative ethical standards in checking and verifying the authenticity of already recorded transactions and thereafter expressing an opinion as to whether the published financial statements and reports were made in all material aspects in accordance with ethical and relevant accounting and financial reporting standards and regulations. By reporting and expressing an opinion the independent auditor helps to establish public confidence and credibility over the financial statements and reports, even though such must not be interpreted as assurance regarding the future sustainability of the enterprise or with regard to the economy, efficiency, or effectiveness of management. The external audit specifically relates to the independent examination of the financial statements of an enterprise by an external auditor appointed by the shareholders. Even though the external auditor may perform the same audit procedures as in the case of the internal auditor, unlike the internal auditor, the external auditor does not report to the board and management but to the shareholders. The external audit is, therefore, important for strengthening transparency and accountability to key external stakeholders in the management of all organizations. External audit as a recognized watchdog mechanism is expected to have probing eyes on the financial statements and reports of the company as a measure of promoting corporate governance and enterprise sustainability. All forms of fraud-sheltering and accounts manipulation by external auditors in collusion with top management of individual companies are unethical and undermine the concept of audit independence; and an invitation to business demise. 230 respondents participated in this study conducted through the exploratory research design, and the result showed a strong relationship between audit process failures and business demise. A recommendation of this report is that the board and management should always ensure to implement credible external auditors’ recommendations as to measures of reducing cases of inefficiency, fraud, and business demise.
Institutions and Credit Ratings
Authors: Elidrissi Anas Moussaid
Published: April 2022

This experiment investigates the relationship between these two traits in order to broaden the view and depict the influence of institutions on not just economic development as conventionally defined but also on country credit ratings. In this work, I demonstrate how we can determine the link between a country's credit ratings and the performance of its institutions. I utilized a data collection of nations and indicators of their performance on institutional indicators, including property rights, judicial efficacy, and so on, in my analysis. Finally, I come to the conclusion that there is a substantial link between an effective institution and a better rating in credit reports conducted by prominent corporations in this field. In terms of trustworthiness, I also note the experiment's limitations.
Is J.S. Mill's Account of Free Speech Sustainable in the Age of Social Media?
Authors: Chellappah Nevin
Published: April 2022

In this paper, I examine whether John Stuart Mill’s account of free speech can survive three main challenges posed by social media. First, I consider the problem of social media failing to distinguish between emotive and factual language. Second, I look at the problem of algorithms creating moralism. I then turn to a potential objection to my first two challenges. The objection elucidates the benefits of social media’s emotional and algorithmic character, amplifying arguments and increasing public engagement. However, I take issue with this objection on consequentialist terms. I finally return to the third challenge, where I focus on how anonymity removes the consequences to our words; I contend that this final failure is the ultimate reason why Mill’s account cannot persist in the modern age. In conclusion, I argue that Mill’s account cannot withstand the problems posed by social media.
Thinking and Speaking
Authors: Gaddam Vaibhav
Published: April 2022

Based on Eli Alshanetsky’s work Articulating a Thought, in this paper, I present a reconstructed puzzle involving complex thoughts and a method for how to tackle articulating them. Then, I reconstruct and provide objections to Alshanetsky’s favored view with rationality. I expound on an initially overlooked deflationary view that is arguably much more viable, while also adding a layer of nuance and granularity to the view that affirms its place in solving the puzzle. I reach the conclusion that if articulation is simply a medium for us to express our complex unfinished thoughts, then perhaps it isn’t necessary for us to clarify the thought.
Putnam's Problem of the Robot and Extended Minds
Authors: Berk Jacob
Published: April 2022

In this paper, I consider Hilary Putnam’s argument for the prima facie acceptance of robotic consciousness as deserving the status of mind. I argue that such an extension of consciousness renders the category fun- damentally unintelligible, and we should instead understand robots as integral products of an extended human conscious- ness. To this end, I propose a test from con- ceptual object permanence, which can be applied not just to robots, but to the in- numerable artifacts of consciousness that texture our existences.
Implementasi Metode Visekriterijumsko Kompromisno Rangiranje (VIKOR) Pada Seleksi Program Keluarga Harapan Komponen Pendidikan Berbasis Web
Authors: Ulhaq Muhammad Dhiya Ulhaq , Irawati
Published: April 2022

Program Keluarga Harapan adalah program pemberian bantuan sosial kepada keluarga miskin yang ditetapkan sebagai penerima. Dalam penelitian ini, sistem pendukung keputusan digunakan untuk mendapatkan hasil keputusan terbaik dengan menggunakan Metode Vikor Multi-Criteria Optimization and Compromise Solution yang merupakan salah satu dari sekian banyak teknik MCDM dalam menentukan hasil keputusan terbaik. Tahap dalam penelitian ini meliputi penentuan Alternatif dan Kriteria selanjutnya dibentuk kedalam matriks yang akan di normalisasi. Tahap berikutnya matriks hasil normalisasi akan dikalikan dengan bobot kriteria yang telah ditentukan sehingga dalam proses selanjutnya dapat dihitung nilai Utility Measure (S) dan Regret Measure (R). Tahap terakhir menghitung indeks Vikor untuk mendapatkan nilai indeks setiap Alternatif, lalu nilai tersebut akan di ranking berdasarkan indeks terbaik. Semakin kecil nilai indeks maka semakin baik hasil keputusan. Berdasarkan hasil pengujian yang telah dilakukan menggunakan teknik Blackbox Testing diperoleh hasil perancangan sistem telah berjalan sesuai perencanaan serta dapat menentukan solusi terbaik pada setiap alternatif.
Simulare e scherzare con la morte: il caso di Inferiorità e dell’Avventura di Maria di Italo Svevo
Authors: Valentini Andrea
Published: April 2022

Il contributo si propone di analizzare due commedie di Italo Svevo, Inferiorità e l’Avventura di Maria, per fornire una nuova chiave di lettura per il teatro dell’autore triestino. La funzione comica di queste opere, il cui clima oscilla costantemente tra quello della pochade e quello del dramma, è data, infatti, da un particolare tipo di umorismo che scherza e gioca con la tematica della morte. I protagonisti, ingabbiati nel salotto-prigione in cui si trovano, saranno latori di un cinico e perturbante humour nero che permetterà loro di segnare una parziale vittoria nei confronti dell’imperturbabile mondo borghese.
La “cadente luna” tra antico e moderno. Sulle trame ossianiche e classiche nell’Ultimo canto di Saffo
Authors: Trovato Lorenzo
Published: April 2022

Il presente articolo raccoglie una serie di osservazioni organiche inerenti alle fonti dell’Ultimo canto di Saffo, canzone che riveste un’importanza cruciale tanto nei Canti quanto in tutta l’esperienza intellettuale di Giacomo Leopardi di cui, in un certo senso, enuclea l’intera parabola. Lo scopo, in particolare, è di far reagire le riprese testuali e contestuali ossianiche con quelle classiche, al fine di coglierne la ratio strutturale e giungere conseguentemente alla formulazione di una proposta ermeneutica.
Akran Zorbalığına Müdahalede Okul Psikolojik Danışmanlarının Yaratıcı Drama Tutumlarının İncelenmesi: TÜBİTAK 4005 Projesi Örneği
Authors: KARTOL Aslı , BULUT Sefa
Published: April 2022

Bu çalışma ile TÜBİTAK 4005 Bilim ve Toplum Yenilikçi Eğitim Uygulamaları tarafından desteklenen 119B118 numaralı “İçindeki Sen Zorbalığı Yen” adlı projenin, okul psikolojik danışmanları üzerinde akran zorbalığına müdahalede yaratıcı drama, psikodrama ve sanat terapisi uygulamalarını içeren eğitim programının yaratıcı drama tutumuna etkisinin belirlenmesi amaçlanmıştır. Çalışma grubunu Türkiye’nin 21 farklı ilinden Milli Eğitime bağlı okullarda görev yapmakta olan 30 okul psikolojik danışmanı oluşturmuştur. Proje akran zorbalığına müdahalede teorik ve uygulamalı etkinlikler ile tek eğitim dönemi olarak 07-11 Ekim 2020 tarihleri arasında yürütülmüştür. Projede katılımcılardan veri toplamak amacı ile Okvuran (2000) tarafından geliştirilen “Yaratıcı Drama Tutum Ölçeği” ile kapalı ve açık uçlu sorulardan oluşan “Görüşme Formu” kullanılmıştır. Proje çalışmasında uygulanan tutum ölçeğinden elde edilen öntest-sontest sonuçlarına göre, projeye katılan okul psikolojik danışmanlarının yaratıcı drama tutumları proje sonrasında anlamlı bir şekilde artış göstermiştir. Görüşme formundan elde edilen bilgilere göre ise katılımcıların büyük çoğunluğunun daha önce yaratıcı drama ile ilgili bir eğitim almadıkları ve projede aldıkları eğitim sonrasında öğrenmiş oldukları yöntem, teknik ve uygulamaları okullarında karşılaşacakları akran zorbalığı problemlerinde etkin olarak kullanacakları bilgisi elde edilmiştir. Verilen cevaplar nicel bulguyu desteklemiştir.
Engelliler Konusunda Ergenlere Verilen Eğitimin Engellilere Yönelik Tutumlarına Etkisi
Authors: ÖZAKAR AKÇA Selen , ÜNAL Zehra , GÖVER Tuğçe , SÖNGÜT Semra
Published: April 2022

Ortaöğretim kurumlarındaki öğrencilerin ergen oldukları ve bu dönemde engellilikle ilgili verilecek eğitimin onlarda oluşabilecek engellilikle ilgili olumsuz tutumlarını engellemesi düşünüldüğünde; bu çalışma ile ergenlerin engellilikle ilgili tutumlarının belirlenmesi ve bu konu ile ilgili verilen eğitimin engellilere yönelik tutumlarına etkisini saptamak amaçlanmıştır. Tek gruplu ön test-son test yarı deneysel desende yapılan bu araştırmanın evrenini, 2016-2017 eğitim-öğretim yılında İç Anadolu Bölgesinde bir il merkezinde bulunan ortaöğretim kurumlarında öğrenim gören 15-18 yaş arası 14,167 ergen oluşturmuştur. Araştırmanın örneklemini ise, tabakalı rastgele örnekleme yöntemi ile seçilen 3,863 ergen oluşturmuştur. Araştırma verileri; Sosyodemografik Anket Formu, Yetersizlikten Etkilenmiş Kişilere Yönelik Tutum Ölçeği (YEKYTÖ) kullanılarak toplanmıştır. Araştırmada verilerin analizinde parametrik testlerden bağımsız iki grup karşılaştırılmasında öğrenci t-testi, ikiden fazla grup karşılaştırmasında ANOVA kullanılmıştır. p<.05 düzeyinde olanlar anlamlı olarak kabul edilmiştir. Araştırmada yer alan ergenlerin %70,2’si 15-16 yaş grubundadır. Ergenlerin %84,9’unun yakınları, %89,0’ının arkadaşları arasında engelli birey bulunmadığı saptanmıştır. Araştırmadaki ergenlerin YEKYTÖ eğitim sonrası puan ortalaması (75,96±14,95) eğitim öncesine (66,69±21,98) göre artmış olup, bu fark istatistiksel olarak anlamlıdır (p<.001). Araştırmadaki ergenlerin ve ailelerinin tanıtıcı özelliklerine, okul bölgelerinin bulunduğu yer ve engelliler ile karşılaşma durumlarına göre eğitim sonrası puan ortalamaları eğitim öncesine göre artmış olup, bu artışın anlamlı olduğu belirlenmiştir (p<.01). Ergenlere verilen engellilere yönelik bilinçlendirme eğitimi, ergenlerin engellilere yönelik tutumlarını olumlu yönde değiştirmektedir.
Pandemi Sürecinde Öğrencilerin “Uzaktan Eğitim” ve “Uzaktan Muhasebe Eğitimi”ne Yönelik Bakış Açıları
Authors: ASLAN ÇETİN Filiz , ÖZTÜRK Seyhan , AKARSU Osman Nuri
Published: April 2022

Bu çalışmanın amacı COVID 19 pandemisinde sosyal bilimlerde öğrenim gören öğrencilerin uzaktan eğitim sistemine ve muhasebe dersi özelinde uzaktan muhasebe eğitimine ilişkin görüşlerini değerlendirmektir. Araştırmanın kapsamına Kafkas Üniversitesi İktisadi ve İdari Bilimler Fakültesi İşletme bölümünde öğrenimini sürdüren 141 kişi girmektedir. Söz konusu araştırma 1 ila 30 Ekim 2020 tarihleri arasında uygulanmıştır. Uygulanan anketlere eksiksiz bir şekilde dönüş yapan 129 kişi ile hedef kitlenin %91’ine ulaşmak mümkün olmuştur. Hazırlanan anket formu, yalnızca işletme bölümünde okuyan ve en az bir muhasebe dersi almış öğrenciler üzerine yapılmıştır. Araştırmaya katılanların yoğunlukla 21-25 yaş aralığında, 4.sınıfta öğrenim gören, büyükşehirlerde yaşayan ve 2.00’den az not ortalamasına sahip erkek öğrenciler olduğu görülmüştür. Katılımcıların en çok akıllı cep telefonları ile günlük olarak uzaktan eğitim sistemini takip ettikleri gözlemlenmiştir. Özellikle öğrencilerin okula gelmeden dersleri takip etme niyeti “çalışıyorum” ifadesiyle dile getirilmiş ve okula gelmeden muhasebe derslerinin takip edilmesinin en büyük dezavantajını “internete ulaşamama” olarak gösterilmiştir. Ayrıca uzaktan eğitim sisteminde ders kayıt sürelerinin 25 dakika üzerinde olması ve ders kayıt videoları yanında PDF, PPT, Word gibi materyallerle de dersin desteklenmesi gerektiğini belirtmişlerdir. Uzaktan eğitim sürecindeki derslerin işlenme tarzını “ilgi çekici” bulmalarına rağmen pandemi bittikten sonra muhasebe derslerinin yüz yüze yapılmasını istemeleri de sonuçlar içerisinde dikkat çekmektedir.
The mutational landscape in chronic myelomonocytic leukemia and its impact on allogeneic hematopoietic cell transplantation outcomes: a Center for Blood and Marrow Transplantation Research (CIBMTR) analysis
Authors: Mei Matthew , Pillai Raju , Kim Soyoung , Estrada-Merly Noel , Afkhami Michelle , Yang Lixin , Meng Zhuo , Abid Muhammad Bilal , Aljurf Mahmoud , Bacher Ulrike , Beitinjaneh Amer , Bredeson Christopher , Cahn Jean-Yves , Cerny Jan , Copelan Edward , Cutler Corey , DeFilipp Zachariah , Diaz Perez Miguel Angel , Farhadfar Nosha , Freytes César O. , Gadalla Shahinaz M. , Ganguly Siddhartha , Gale Robert Peter , Gergis Usama , Grunwald Michael R. , Hamilton Betty K. , Hashmi Shahrukh , Hildebrandt Gerhard C. , Lazarus Hillard M. , Litzow Mark , Munker Reinhold , Murthy Hemant S. , Nathan Sunita , Nishihori Taiga , Patel Sagar S. , Rizzieri David , Seo Sachiko , Shah Mithun Vinod , Solh Melhem , Verdonck Leo F. , Vij Ravi , Sobecks Ronald M. , Oran Betul , Scott Bart L. , Saber Wael , Nakamura Ryotaro
Published: April 2022

Somatic mutations are recognized as an important prognostic factor in chronic myelomonocytic leukemia (CMML). However, limited data are available regarding their impact on outcomes after allogeneic hematopoietic cell transplantation (HCT). In this registry analysis conducted in collaboration with the Center for International Blood and Marrow Transplantation Registry database/sample repository, we identified 313 adult patients with CMML (median age: 64 years, range, 28- 77) who underwent allogeneic HCT during 2001-2017 and had an available biospecimen in the form of a peripheral blood sample obtained prior to the start of conditioning. In multivariate analysis, a CMML-specific prognostic scoring system (CPSS) score of intermediate-2 (HR=1.46, P=0.049) or high (HR=3.22, P=0.0004) correlated significantly with overall survival. When the molecularly informed CPSS-Mol prognostic model was applied, a high CPSS-Mol score (HR=2 P=0.0079) correlated significantly with overall survival. The most common somatic mutations were in ASXL1 (62%), TET2 (35%), KRAS/NRAS (33% combined), and SRSF2 (31%). DNMT3A and TP53 mutations were associated with decreased overall survival (HR=1.70 [95% CI: 1.11-2.60], P=0.0147 and HR=2.72 [95% CI: 1.37-5.39], P=0.0042, respectively) while DNMT3A, JAK2, and TP53 mutations were associated with decreased disease-free survival (HR=1.66 [95% CI: 1.11-2.49], P=0.0138, HR=1.79 [95% CI: 1.06-3.03], P=0.0293, and HR=2.94 [95% CI: 1.50-5.79], P=0.0018, respectively). The only mutation associated with increased relapse was TP53 (HR=2.94, P=0.0201). Nonetheless, the impact of TP53 mutations specifically should be interpreted cautiously given their rarity in CMML. We calculated the goodness of fit measured by Harrell’s C-index for both the CPSS and CPSS-Mol, which were very similar. In summary, via registry data we have determined the mutational landscape in patients with CMML who underwent allogeneic HCT, and demonstrated an association between CPSS-Mol and transplant outcomes although without major improvement in the risk prediction beyond that provided by the CPSS.
Economic Criteria for Optimizing the Assigned Service Life of Machinery and Equipment
Authors: Smolyak Sergey A.
Published: April 2022

The machine is used in a continuous production process in the enterprise that is a market participant. During its use, it can be subject to random failure after which losses occur due to interruption of the process. After failure, the machine is decommissioned and disposed of. Over time, the failure rate increases. Under these conditions, it turns out to be beneficial for the enterprise to set an assigned service life for the machine, after which (if no failure has occurred) it must be disposed of. We solve the problem of optimizing the assigned service life. Usually, to solve this problem, various optimality criteria are used, for example, average costs per unit of time (including the time to eliminate the consequences of a failure), reliability indicators, or other indicators that do not fully reflect the commercial interests of the enterprise owning the machine. Using the principles and methods of asset valuation, we build a mathematical model that allows us to calculate the optimal assigned life of the machine and at the same time assess the market value of the work performed by it. At the same time, in this problem, the optimality criterion is the ratio of the expected discounted costs to the expected discounted volume of work performed by the machine (in units of operating time). Using this criterion, the market value of the enterprise owning the machine will be the highest. The proposed model allows us to estimate the market value of the serviceable machine knowing its age. We compare the proposed and alternative optimality criteria. We give an example in which machine failures have a Rayleigh distribution. The proposed general approach can be used both in solving other optimization problems of reliability theory and for practical valuation of some types of machinery and equipment.
Money Is a Sign
Authors: Egorov Dmitry G.
Published: April 2022

The work is devoted to the problem of defining the category of «money». To correctly define the concept of «money», one should: 1) conduct a logical analysis of the main forms and types of money for what unites them all, while 2) take into account that money does not exist outside time and space, but in the economic system. A sign is an object that replaces another object in someone's mind (which is the meaning of a sign). Еconomic relations in many cases are fixed in symbolic form. What is included in the symbolic subsystem of the economy? – ​signs of property rights; debt signs; and finally, money. Is money a sigh? Money is a legitimate sign of value. Money, in accordance with our definition (and with the real state of affairs), is an object that denotes a particular measure of value. At the same time, what kind of object is the bearer of the sign is a question that has nothing to do with the essence of money. Money can be classified according to what is the substrate of the sign: metal, paper (banknotes), credit (records on bank accounts), electronic. The differences in the substrates of money are the basis for the advancement of various genetic theories of the origin of money. all of them, in essence, can be reduced to the commodity-metal concept and the concept of state-legal (nominalist, contractual, debt). The presence of these two genetic concepts is associated with two fundamentally different types of legitimization of banknotes: 1) direct, when the substrate of the sign has a value that it symbolizes (coins made of gold or silver); 2) mediated (fiat money). The solution to this problem of the external duality of money is in the understanding that money is essentially a sign. This is what unites everyone. The difference between the forms of money is in the form of legitimization (directly commodity, or legal).
‘IS THE PICTURE WORTH A THOUSAND WORDS?’: THE INTERPERSONAL MEANINGS OF A DIALOGUE IN AN EFL TEXTBOOK
Authors: Sugianto Ahmad , Prasetyo Ilham Agung , Asti Widy
Published: April 2022

This study was aimed at scrutinising a multimodal text embedded in a dialogue of an EFL textbook. To this end, Systemic Functional Multimodal Discourse Analysis (SF-MDA) focused on interpersonal meanings consulting grammar of visual design and intersemiotic complementarity drawing on systemic functional linguistics were employed to analyse the artefact, a dialogue within a part named 'communication' taken from an EFL textbook for a primary school level. The findings revealed that declarative clause and modalisation (epistemic modality) of probability was found to be the most common system used in the verbal text. Meanwhile, high modality and validity were found in the visual image indicated by the realisations and representations of detailed abstraction and full-colour saturation. Finally, the study draws a conclusion that there is a cohesive interaction to a certain extent between the verbal text and the visual image represented in the multimodal dialogue.
ACTIVE LEARNING: MONOPOLY AS A MEDIA IN TEACHING GRAMMAR FOR EIGHT GRADER STUDENTS
Authors: Lestari Ananda Dewi , Ningrum Ary Setya Budhi
Published: April 2022

The diversity in English performance is quite prominent when viewed from students' grammatical competence. For this reason, grammar learning innovation is needed so that student mastery improves. This study aims to investigate the effectiveness of using board game Engpoly (English Monopoly) in learning grammar for eight-grader students. It also provides reflection on student learning strategies in studying grammar. The design used a quasi-experimental design. For collecting the data, the researchers applied post-test and pre-test as research instruments. It involved two classes as a control group and an experimental group. The ANCOVA test results showed the significance of using Engpoly media in learning grammar. The finding also demonstrated that the use of fun media in the form of games can increase students' interest in learning grammar which was initially considered a very boring lesson by most students. It also encouraged student's active learning. This media has been proven to relate between the characteristics of eighth-grade students at junior high school with the appropriate grammar learning strategies they need. Since the use of Engpoly in grammar learning has a significant contribution, this study recommends that English teachers can develop Engpoly media for teaching grammar not only to eighth-graders but also to several other levels of english proficiency.
EXPLORING STUDENTS’ EXPERIENCES OF TASK-BASED LANGUAGE TEACHING (TBLT) IN VOCABULARY LEARNING: A NARRATIVE INQUIRY
Authors: Putri Windi Melia
Published: April 2022

Task-based language teaching (TBLT) is a learning method that is considered more comprehensive compared to the communicative method which has been considered far more useful in language teaching. TBLT proposes the use of tasks as a main component in language classroom because it provides better context for learners to activate their acquisition process and promote second language learning. The current research compares the growth of students vocabulary knowledge in English. The purpose of this study is to know the students’ experiences of TBLT in vocabulary learning. The qualitative research method used in this study is a narrative inquiry. Data was collected through interviews specially semi structure interview based on interview guideline and data analysis by involving students in the online learning process. The findings provide information about the learning process as well as the advantages of TBLT in vocabulary learning. The interview results show that students in general have a positive attitude toward learning vocabulary through TBLT method. Keywords: Students’ Experiences; Task Bask Language Teaching, Vocabulary Learning
CHALLENGES ENCOUNTERED BY THE TEACHERS HANDLING ORAL SPEECH COMMUNICATION COURSES IN THE ERA OF COVID-19 PANDEMIC
Authors: Gula Louie Petere
Published: April 2022

The fundamental reason for this survey is to point out the challenges encountered by the teachers, students, schools, and parents in facing and handling the oral communication subject during the pandemic. Given that, most of the medium of instruction we are using now is distance learning, it poses issues and concerns on how our respondents dealt with the situation. A descriptive- survey research design was being utilized to document the behavior, demographics, and experiences of the respondents correlated to the questions provided. The questionnaire includes questions that seek to gather information on their basic profile, current experiences, and behavior towards the problem. Therefore, I have narrowed down the different problems encountered by the teachers, students, school, and parents based on the responses I have collected. Some respondents answered the same problem encountered that leads to the validity of the issue. Most of the teachers encountered the problem of the students with lack of motivation which is indeed a very complicated problem because it deals with emotional readiness and stability. The students’ side of encountering a problem is the difficulty in comprehending the topics of the module because lessons are not explained personally by the teachers.
THE EFFECTS OF VOCABULARY MASTERY ON ENGLISH-SPEAKING ABILITY: A META-ANALYSIS STUDY
Authors: Br Bangun Helli Kristiana , Simanjuntak Debora Chaterin
Published: April 2022

The purpose of this meta-analysis is to analyse the effects of vocabulary mastery on English-speaking ability, which has been a extensively focused on English language teaching. A descriptive qualitative technique was utilized in this study. The data of this study consisted of 820 samples from 21 studies that focused on the correlation between students' sufficient academic vocabulary and English-speaking ability. The meta-analysis involves the studies conducted in Indonesia to draw deeper characteristics of the phenomena. The r and n were found in the data. n is the number of respondents, and r is the coefficient value. The researchers utilized five procedures to acquire the data: collecting studies or meta-analysis materials; calculating the effect size of each study; estimating the summary effect or mean effect size; analyzing the standard error; and evaluating publication bias. The data was analyzed with the help of JASP program. Because K = 21, 5K+10 Equals 115. The obtained fail-safe N value is 4727.000, with a significant target of 0.05 and p < 0.001. Because N > 5K+10 is a safe value, it is assumed that no publication bias exists in the Meta-Analysis study. In addition, the study's findings demonstrate that having an adequate academic vocabulary has a positive impact on English-speaking skills.
Pandemic Election: The Interactive Effects of COVID-19 and Age Across States and Counties in the 2020 Presidential Election
Authors: Scheller Daniel
Published: April 2022

The 2020 Presidential General Election represented the first modern presidential election to occur during a pandemic. The highly contagious coronavirus presented added risk for in-person voting, especially among the 60+ population. What effect did the Covid-19 pandemic have on in-person voting across states and counties? This paper builds off of previous research conducted by the author that found an interactive effect between county Covid-19 rates and voter age during the Florida 2020 Presidential Preference Primary in March 2020. Older voters in counties with a high Covid-19 rate were less likely to turnout than younger voters in low Covid-19 counties. Does this pattern remain nearly 8 months later in Florida and other states? Using individual voter data from Arizona and Florida, I study the interactive effects of a voter's age with the level of Covid-19 prevalence in their respective county on their likelihood of voting in person on Election Day.
Generalized Kibria-Lukman Estimator: Method, Simulation, and Application
Authors: Dawoud Issam , Abonazel Mohamed R. , Awwad Fuad A.
Published: April 2022

In the linear regression model, the multicollinearity effects on the ordinary least squares (OLS) estimator performance make it inefficient. To solve this, several estimators are given. The Kibria-Lukman (KL) estimator is a recent estimator that has been proposed to solve the multicollinearity problem. In this paper, a generalized version of the KL estimator is proposed, along with the optimal biasing parameter of our proposed estimator derived by minimizing the scalar mean squared error. Theoretically, the performance of the proposed estimator is compared with the OLS, the generalized ridge, the generalized Liu, and the KL estimators by the matrix mean squared error. Furthermore, a simulation study and the numerical example were performed for comparing the performance of the proposed estimator with the OLS and the KL estimators. The results indicate that the proposed estimator is better than other estimators, especially in cases where the standard deviation of the errors was large and when the correlation between the explanatory variables is very high.
N-Tools-Browser: Web-Based Visualization of Electrocorticography Data for Epilepsy Surgery
Authors: Burkhardt Jay , Sharma Aaryaman , Tan Jack , Franke Loraine , Leburu Jahnavi , Jeschke Jay , Devore Sasha , Friedman Daniel , Chen Jingyun , Haehn Daniel
Published: April 2022

Epilepsy affects more than three million people in the United States. In approximately one-third of this population, anti-seizure medications do not control seizures. Many patients pursue surgical treatment that can include a procedure involving the implantation of electrodes for intracranial monitoring of seizure activity. For these cases, accurate mapping of the implanted electrodes on a patient’s brain is crucial in planning the ultimate surgical treatment. Traditionally, electrode mapping results are presented in static figures that do not allow for dynamic interactions and visualizations. In collaboration with a clinical research team at a Level 4 Epilepsy Center, we developed N-Tools-Browser, a web-based software using WebGL and the X-Toolkit (XTK), to help clinicians interactively visualize the location and functional properties of implanted intracranial electrodes in 3D. Our software allows the user to visualize the seizure focus location accurately and simultaneously display functional characteristics (e.g., results from electrical stimulation mapping). Different visualization modes enable the analysis of multiple electrode groups or individual anatomical locations. We deployed a prototype of N-Tools-Browser for our collaborators at the New York University Grossman School of Medicine Comprehensive Epilepsy Center. Then, we evaluated its usefulness with domain experts on clinical cases.
Microneedle-Based Device for Biological Analysis
Authors: Lu Huiting , Zada Shah , Yang Lingzhi , Dong Haifeng
Published: April 2022

The collection and analysis of biological samples are an effective means of disease diagnosis and treatment. Blood sampling is a traditional approach in biological analysis. However, the blood sampling approach inevitably relies on invasive techniques and is usually performed by a professional. The microneedle (MN)-based devices have gained increasing attention due to their noninvasive manner compared to the traditional blood-based analysis method. In the present review, we introduce the materials for fabrication of MNs. We categorize MN-based devices based on four classes: MNs for transdermal sampling, biomarker capture, detecting or monitoring analytes, and bio-signal recording. Their design strategies and corresponding application are highlighted and discussed in detail. Finally, future perspectives of MN-based devices are discussed.
Differential Expression of E2F Transcription Factors and Their Functional and Prognostic Roles in Human Prostate Cancer
Authors: Han Zhaodong , Mo Rujun , Cai Shanghua , Feng Yuanfa , Tang Zhenfeng , Ye Jianheng , Liu Ren , Cai Zhiduan , Zhu Xuejin , Deng Yulin , Zou Zhihao , Wu Yongding , Cai Zhouda , Liang Yuxiang , Zhong Weide
Published: April 2022

Given the tumor heterogeneity, most of the current prognostic indicators cannot accurately evaluate the prognosis of patients with prostate cancer, and thus, the best opportunity to intervene in the progression of this disease is missed. E2F transcription factors (E2Fs) have been reported to be involved in the growth of various cancers. Accumulating studies indicate that prostate cancer (PCa) carcinogenesis is attributed to aberrant E2F expression or E2F alteration. However, the expression patterns and prognostic value of the eight E2Fs in prostate cancer have yet to be explored. In this study, The Cancer Genome Atlas (TCGA), Kaplan–Meier Plotter, Metascape, the Kyoto Encyclopedia of Genes and Genomes (KEGG), CIBERSORT, and cBioPortal and bioinformatic analysis were used to investigate E2Fs in patients with PCa. Our results showed that the expression of E2F1–3, E2F5, and E2F6 was higher in prostate cancer tissues than in benign tissues. Furthermore, elevated E2F1–3 and E2F5 expression levels were associated with a higher Gleason score (GS), advanced tumor stage, and metastasis. Survival analysis suggested that high transcription levels of E2F1–3, E2F5, E2F6, and E2F8 were associated with a higher risk of biochemical recurrence. In addition, we developed a prognostic model combining E2F1, E2F6, Gleason score, and the clinical stage that may accurately predict a biochemical recurrence-free survival. Functional enrichment analysis revealed that the E2F family members and their neighboring genes were mainly enriched in cell cycle-related pathways. Somatic mutations in different subgroups were also investigated, and immune components were predicted. Further experiments are warranted to clarify the biological associations between Pca-related E2F family genes, which may influence prognosis via the cell cycle pathway.
Condensed Mitochondria Assemble Into the Acrosomal Matrix During Spermiogenesis
Authors: Ren Mindong , Xu Yang , Phoon Colin K. L. , Erdjument-Bromage Hediye , Neubert Thomas A. , Rajan Sujith , Hussain M. Mahmood , Schlame Michael
Published: April 2022

Mammalian spermatogenesis is associated with the transient appearance of condensed mitochondria, a singularity of germ cells with unknown function. Using proteomic analysis, respirometry, and electron microscopy with tomography, we studied the development of condensed mitochondria. Condensed mitochondria arose from orthodox mitochondria during meiosis by progressive contraction of the matrix space, which was accompanied by an initial expansion and a subsequent reduction of the surface area of the inner membrane. Compared to orthodox mitochondria, condensed mitochondria respired more actively, had a higher concentration of respiratory enzymes and supercomplexes, and contained more proteins involved in protein import and expression. After the completion of meiosis, the abundance of condensed mitochondria declined, which coincided with the onset of the biogenesis of acrosomes. Immuno-electron microscopy and the analysis of sub-cellular fractions suggested that condensed mitochondria or their fragments were translocated into the lumen of the acrosome. Thus, it seems condensed mitochondria are formed from orthodox mitochondria by extensive transformations in order to support the formation of the acrosomal matrix.
Urinary Tract Infections Caused by K. pneumoniae in Kidney Transplant Recipients – Epidemiology, Virulence and Antibiotic Resistance
Authors: Krawczyk Beata , Wysocka Magdalena , Michalik Michał , Gołębiewska Justyna
Published: April 2022

Urinary tract infections are the most common complication in kidney transplant recipients, possibly resulting in the deterioration of a long-term kidney allograft function and an increased risk of recipient’s death. K. pneumoniae has emerged as one of the most prevalent etiologic agents in the context of recurrent urinary tract infections, especially with multidrug resistant strains. This paper discusses the epidemiology and risk factors associated with urinary tract infections in kidney transplant recipients, multi-drug resistance of K. pneumoniae (ESBL, KPC, NDM), treatment and pathogenesis of K. pneumoniae infections, and possible causes of recurrent UTIs. It also addresses the issue of colonization/becoming a carrier of K. pneumoniae in the gastrointestinal tract and asymptomatic bacteriuria in relation to a symptomatic UTI development and epidemiology.