bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Staffing dan Beban Kerja Terhadap Prestasi Kerja Karyawan di Pabrik Gula Djombang Baru
Authors: Amany Ahsana Nadiyya
Published: June 2022

The purpose of this analyze the effect of staffing and workload toward employee work performance at Sugar Factory of Djombang Baru. This type of research is associative description and sample collection techniques are purposive side techniques with a total sample of 122 employees of Sugar Factory in Djombang Baru. Data collection techniques using observation, interviews, questionnaires and documentation. Data analysis techniques using multiple linier regression. The results of this study indicate that, 1) Staffing has a partially significant effect on the work performance  Djombang Baru Sugar Factory employees, 2) Workload has partially significant effect on the work performance Djombang Baru Sugar Factory employees and, 3) Staffing and workload simultaneously affects work performance of Djombang Baru Sugar Factory employees.
Pengaruh Lingkungan Kerja dan Stres Kerja Tehadap Kepuasan Kerja Karyawan di Pabrik Gula Meritjan Kediri
Authors: Ansori Achmad Rosidi
Published: June 2022

This study aims to determine the influence of the work environment and work stress on employee job satisfaction at the Meritjan Kediri Sugar Factory.  In this study using quantitative data analysis techniques and using observation data collection techniques and using primary data obtained from questionnaires.  The sample in this study was 95 employees.  The sample is taken by using the Random Sampling technique, which is taking the sample members from the population randomly without paying attention to the strata in the population.  Data analysis techniques using Multiple Linear Regression. The results showed that: (1) The work of environment partially influences employee job satisfaction at the Meritjan Kediri Sugar Factory. (2) Job stress partially influences the job satisfaction of employees at Meritjan Kediri Sugar Factory. (3) Work environment and work stress simultaneously affect the job satisfaction of employees at Meritjan Kediri Sugar Factory.
Pengaruh Kesehatan Keselamatan Kerja (K3) dan Motivasi Kerja Terhadap Kinerja Karyawan (Studi Pada Karyawan Pg. Djombang Baru)
Authors: Hidayati Roudhotul
Published: June 2022

The research purpose of this is to find whether there is or not the influence of work safety health and work motivation toward employees’ performance. This is an associative descriptive research using purposive sampling as the sampling technique with 123 employees. Meanwhile, the techniques of data collection used are observation, interview, questionnair and documentation.  The research results show that, (1) Work safety health influences performance employees positive-partially. (2) Work motivation influences employees’ performance positive-partially. (3) Work safety health and work motivation influence employees’ performance simultaneously.
Pengaruh Kompetensi Terhadap Kinerja Karyawan Melalui Kepuasan Kerja : Studi Literatur
Authors: Rijal Achmad Farid Nur
Published: June 2022

Article investigate the influence of competence on performance, competence on job satisfaction, job satisfaction on performace, and competence on performance through job satisfaction. The literature study were based on empirical studies from any national and international journals. Data collected by using a search engine methods. The results suggest that competence has positive significant effect on performance, competence has positive significant effect on job satisfaction,job satisfaction has positive significant effect on performace, and competence has positive significant effect on job satisfaction through job satisfaction.
Pengaruh Dimensi Experiential Marketing Terhadap Kepuasan Pelanggan di Mulyo Redjo Jombang
Authors: Aziz Farid Isnan , Sudarwanto Tri
Published: June 2022

The purpose of this research is to examine the presence or absence of influence between sense, feel, think, act, and relate to customer satisfaction at Mulyo Redjo Jombang. The method used in this study is a quantitative research method and uses a causal or causal approach. With a sample size of 100 respondents is using non probability sampling techniques through the Purposive Sampling method. The results of the study show that: (1) Sense partially influences customer satisfaction at Warung Lesehan Mulyo Redjo Jombang, (2) Feel has no partial effect on customer satisfaction at Warung Lesehan Mulyo Redjo Jombang, (3) Think partially influences customer satisfaction at Warung Lesehan Mulyo Redjo Jombang, (4) Act partially influences customer satisfaction at Warung Lesehan Mulyo Redjo Jombang, (5) Relate does not have a partial effect on customer satisfaction at Warung Lesehan Mulyo Redjo Jombang, (6) Sense, feel, think, act, and relate simultaneously affect customer satisfaction at Warung Lesehan Mulyo Redjo Jombang.
Pengaruh Penyajian dan Aksesibilitas Laporan Realisasi Dana Desa Terhadap Akuntabilitas Pengelolaan Dana Desa (Studi Kasus Desa Pulosari, Kecamatan Bareng, Kabupaten Jombang)
Authors: Mureni Siti
Published: June 2022

This type of research is quantitative research. Data collection technique used is questionnaires. The purpose of the study was to determine the effect of the presentation and accessibility of the report on the realization of village funds on the accountability of village fund management in Pulosari, Bareng , Jombang. The data analysis technique used is multiple linear regression analysis. The results of this study indicate a positive and significant influence from the presentation and accessibility of the realization report on the accountability of village fund management. This shows that if the Pulosari government presents a report on the realization of village funds well and the accessibility of reports is easy to obtain, it will increase the accountability of the Pulosari government. The Accountability is needed as an illustration that the organization of the organization is going well.
Pengaruh Rasio Likuiditas, Solvabilitas dan Profitabilitas Terhadap Kinerja Keuangan pada Sub Sektor Perbankan Konvensional yang Terdaftar di Bursa Efek Indonesia Periode 2013-2017
Authors: Harianto Fuji , Zutiasari Ika
Published: June 2022

This research has purpose to test the influence of liquidity ratio with formula Loan to Deposit Ratio (LDR), solvency ratio with formula Capital Adequacy Ratio (CAR) and profitability ratio with operating expense operating income (BOPO) toward financial performance with formula Return on Asset (ROA). This research using time series data from financial report and annual reports banking firms wich listed on BEI. After passed the purposive sampling phase, then the sample that are worth using are 32 banking companies firms wich listed on BEI. The analysis technique used is multiple regression analysis. From the F test shows that of liquidity, solvency and profitability variable simultaneously affect significantly to financial performance Return On Asset (ROA). The result of t test shows that liquidity ratio (LDR) and solvency (CAR) variables has not significant effect to the financial performance (ROA). Profitability (BOPO) variable has a negative and significant effect to the financial performance (ROA).
Peran Program BISA (Bunda Mandiri Sejahtera) Dalam Meningkatkan Pemberdayaan Ekonomi Masyarakat (Studi Kasus di Yatim Mandiri Jombang)
Authors: Kafiludin M.
Published: June 2022

This study aims to (1) find out how the model of community economic empowerment program through the BISA (Bunda Mandiri Sejahtera) program in Yatim Mandiri Jombang (2) determine the effect of the economic empowerment model through the BISA (Bunda Mandiri Sejahtera) program on improving the economy of the community. This study uses a qualitative approach with field research, library research and interviews. Because this research is a research which is sourced from field date and literature, the analysis that the researcher uses is descriptive analysis by describing the facts in the field so that it is easy to understand, then by deductive and descriptive methods to study and describe the situation in detail. The results of this study (1) the Bunda Mandiri Sejahtera (BISA) program increased the empowerment of Bunda yatim. Six of the eight indicators fulfilled consist of worship, neighboring, eating and drinking, housing, recreation, social activities. Two indicators were not met from economic empowerment, namely vehicles and education. (2) Bunda Mandiri Sejahtera (BISA) program model has been able to be implemented properly so that orphans who participate in the BISA program are able to benefit from BISA program activities (3) Sejahtera (BISA) runs an empowerment program based on 3 social aspects, Economics and Human Resources.
Analisis Penerapan Prinsip Syari’ah Terhadap Aplikasi Hasanah Card di BNI Syari’ah Kantor Cabang Surabaya
Authors: Savitri Marisa Amalia , Sudarwanto Tri , Hidayati Athi’
Published: June 2022

The purpose of this study was to find out whether the Hasanah Card had actually implemented the Sharia Card Principles described in Fatwa DSN-MUI No. 54.The research method used is a descriptive approach by combining types of qualitative research. Data collection was conducted by interviewing the Hasanah Card Marketing Division, employees and Hasanah Card customers, direct participatory observation, and documentation. Data validity techniques use credibility techniques (internal validity), transferability (external validity), dependability (reliability), and confirmability (objectivity). Data analysis techniques use inductive, deductive, and comparative methods. The results of this study are the application of sharia principles on hasanah cards conducted by BNI Syariah KC Surabaya still not in accordance with Fatwa DSN-MUI No. 54. This can be seen from the DSN-MUI fatwa No.54 Based on the fatwa stipulated by the Sharia card, it cannot be used for transactions that are not in accordance with sharia. However, there is a difference between the DSN-MUI fatwa on sharia cards and the practices that occur in Islamic banks where credit card customers do not apply the use of Islamic credit cards in accordance with the provisions
Pengaruh CAR, FDR, NPF, BOPO dan BI Rate Terhadap Profitabilitas (Studi pada PT.Bank Syariah Bukopin)
Authors: Sumarmi Sumarmi , Sopingi Imam , Sudarwanto Tri
Published: June 2022

This study aims to examine the effect of CAR, FDR, NPF, BOPO, and BI Rate variables on ROA in Bukopin Sharia Bank for the period of 2009-2018. The data used in this study were obtained from Bukopin Sharia Bank Quarterly Publication Financial Reports for the period 2009-2018 and BI. The number of samples used in this study were 40 data. The results showed that, CAR had a positive and significant effect on ROA, FDR had no effect on ROA, NPF had no effect on ROA, BOPO had a significant negative effect on ROA, and the BI Rate variable had no effect on ROA. The predictive ability of the five variables at ROA is 98.9%, and 1.1% is influenced by other factors outside the research model. The results of this study are expected to be able to become a guideline for the management of Bukopin Sharia Bank in managing the bank.
Analisis Penyelesaian Tindakan Side Streaming pada Pembiayaan Murabahah dalam Perspektif Fikih Muamalah di BRISyariah KC Jombang
Authors: Azmil Futihatul Rizqiyah
Published: June 2022

This research aims to analize the completion of side streaming actions on murabahah financing at BRISyariah KC Jombang and its review of fiqh muamalat. The method of this research used fiqheconomic approach with  descriptive normative data analysis. Data field finding about the completion of side streaming were analyzed with refers to fiqh muamalat law. The results showed  that the completion of side streaming actions on murabaha financing at BRISyariah was carried out in a persuasive way with administrative control. In the fiqh muamalat study, side streaming made a contract into fasakh. The solution of fasakh contract due to the side streaming is by changing the contract or re-contract. Practically, the completion of side streaming at BRISyariah KC Jombang has not fully accordance with fiqh muamalat because there is still not achieving the purpuso of the contract.
Faktor – Faktor Yang Berdampak Terhadap Pendapatan Margin Murabahah Pada Bank BRI Syariah Periode 2012 - 2019
Authors: Ahmad Fatkhur Rizqi  , Dardiri Masyhudan
Published: June 2022

This study objective to  examine factor the impact income margin Murabahah in islamic banking Indonesia. Multiple   linier  regreson  analysis, coefficient of  determination, hypotesis testing and the classical   assumption  is the analyctic tool in this research. The islam bank in indonesia are the populaton in this study,   while . The sampling of this resarch is the bank BRI syariah in Indonesia by using saturated sampling method. The result show that, (1) the Murabahah Financing has a partial impact on the Murabahah margin income (2) the third party funds have a partial impact on the Murabahah margin income in BRI syariah, (3) the BI Rate has a partial impact on the Murabahah margin income in BRI syariah, and (4) the operational cost have a partial impact on Murabahah margin income in BRI syariah, while Variabel Murabahah Financing, Third Party Funds, BI Rate, and Operational Cost have a simultaneous impact on Murabahah margin income. The result of the coefficient of determination on the ajusted R Square value is 0.834, which means that the variable Murabahah Financing, Third Party Funds, BI Rate and Operational Cost impact Murabahah margin income by 83.4%
Keywords : Murabahah margin, third party funds, BI Rate, biaya opearsional
Analisis Strategi Program Investor Gathering Terhadap Peningkatan Transaksi Saham Di Pasar Modal
Authors: Nizamudin Aulia Athif , Ashlihah
Published: June 2022

Penelitian ini bertujuan untuk memperoleh bukti empiris mengenai “Analisis Strategi Program Investor Gathering Terhadap Peningkatan Transaksi Saham di Pasar Modal”. Penelitian ini diharapkan dijadikan bahan pertimbangan perusahaan dalam menetapkan kebijakan-kebijakan yang ada dalam perusahaan, dan hasil penelitian ini dapat menambah kepustakaan dan dapat dijadikan bahan referensi untuk penelitian selanjutnya.Metode penelitian yang digunakan adalah analisis deskriptif kualitatif. Pengumpulan data yang digunakan adalah wawancara, observasi dan dokumentasi. Pengumpulan data di lapangan dilaksanakan pada tahun 2019. Hasil penelitian menunjukkan bahwa peningkatan transaksi saham di pasar modal sangat di pengaruhi oleh program investor gathering yang dilaksanakan oleh perusahaan.

Kata kunci: Investor Gathering, Transaksi Saham, Pasar Modal
Hakikat Peran Intermediasi Bank Syariah Bagi Masyarakat Pada PT BPRS Lantabur Tebuireng Jombang
Authors: Afifah Nur , Haryanti Peni
Published: June 2022

Penelitian ini bertujuan untuk mengetahui hakikat peran intermediasi bank syariah bagi masyarakat pada PT BPRS Lantabur Tebuireng Jombang, apakah sudah berjalan sebagaimana hakikatnya (intermediasi keuangan dan sosial) serta yang menjadi faktor pendukung dan penghambat dalam penerapannya. Penelitian ini menggunakan pendekatan fenomenologi dengan jenis penelitian field research dan menekankan pada uji triangulasi data. Hasil penelitian menunjukkan bahwa (1) peran intermediasi BPRS Lantabur Tebuireng Jombang sudah berjalan sebagaimana hakikatnya yaitu menerapkan peran intermediasi keuangan dan intermediasi sosial. Dalam menjalankan perannya sebagai intermediasi keuangan telah diterapkan dengan baik, namun perannya sebagai intermediasi sosial kurang berjalan dengan baik. Adapun (2) faktor pendukung peran intermediasi BPRS Lantabur Tebuireng Jombang yaitu adanya hukum positif, hukum Al-Qur’an, motto dan visi misi BPRS Lantabur Tebuireng Jombang, serta bekerja sama dengan Lembaga Sosial Pesantren Tebuireng (LSPT). Sedangkan faktor penghambat yaitu kurangnya dana sosial, kurangnya penyandang dana untuk produk qardhul hasan, dan tidak menjalankan fungsi maal yaitu menerima dana zakat, infak, sedekah (ZIS).
Kata kunci: Peran; Intermediasi; Bank Syariah; Masyarakat; BPRS
Pengaruh Financial Screening Terhadap Nilai Perusahaan Sektor Pertanian Di Bursa Efek Indonesia
Authors: Islami Intan Rulisa , Aji Tony Seno
Published: June 2022

Nilai perusahaan sektor pertanian yang terdaftar di Bursa Efek Indonesia pada periode 2015-2018 mengalami tren penurunan. Tren penurunan ini sejalan dengan turunnya jumlah saham sektor pertanian yang terdaftar sebagai saham syariah pada periode yang sama. Penelitian ini bertujuan untuk mengetahui pengaruh financial screening yang merupakan indikator penentu saham syariah terhadap nilai perusahaan sektor pertanian yang terdaftar di Bursa Efek Indonesia periode 2015-2018. Penelitian ini mengukur financial screening dengan melihat apakah perusahaan terdaftar atau tidak terdaftar dalam Indeks Saham Syariah Indonesia (ISSI) dan nilai perusahaan dengan rasio PBV. Metode penelitian yang diguanakan adalah regresi data panel dengan pendekatan random effect model. Hasil penelitian menunjukkan bahwa financial screening tidak memiliki pengaruh terhadap nilai perusahaaan.
Kata kunci: Financial Screening; Saham Syariah; Nilai Perusahaan
Pengaruh Produk Pembiayaan Dan Dana Pihak Ketiga Terhadap Profitabilitas Bank Umum Syariah Di Indonesia (Studi Masa Pandemi Covid-19)
Authors: Fahma Diana Fada
Published: June 2022

Penelitian ini dimaksudkan agar dapat mengetahui dan juga melaksanakan penganalisisan mengenai pengaruh dari variabel produk pembiayaan dan dana pihak ketiga (DPK) pada variabel profitabilitas dari Bank Umum Syariah yang ada di negara Indonesia untuk masa pandemi seperti sekarang ini. Untuk penelitian ini, teknik pengumpulan data penelitian yang dilaksanakan ialah berupa studi dokumentasi, yakni laporan keuangan setiap bank umum syariah dan juga studi pustaka. Untuk penelitian ini, data penelitian yang dipergunakan ialah berupa data sekunder, yang didapatkan dari website resmi Bank Umum Syariah periode bulan april 2020 sampai bulan maret 2021. Untuk analisis statistik yang dimanfaatkan ialah berupa analisis regresi berganda dengan berbantuan SPSS 25. Hasil uji hipotesis penelitian yang dihasilkan memperlihatkan bahwa variabel produk pembiayaan memberi sumbangsih pengaruh senilai (5.517> 1.977) pada variabel profitabilitas bank umum syariah, untuk dana pihak ketiga sebesar (3.137>1.977) yang menggambarkan adanya signifikansi terhadap profitabilitas Bank Umum Syariah, sedangkan secara simultan produk pembiayaan dan dana pihak ketiga berpegaruh secara signifikan terhadap profitabilitas. Sehingga diperoleh kesimpulan bahwa produk dan dana pihak ketiga berpengaruh terhadap profitabilitas bank umum syariah pada masa pandemi covid-19
Kata kunci: Produk Pembiayaan, Dana Pihak Ketiga, Profitabilitas Bank Umum Syariah, Covid-19
Interactions Between a Marine Heatwave and Tropical Cyclone Amphan in the Bay of Bengal in 2020
Authors: Rathore Saurabh , Goyal Rishav , Jangir Babita , Ummenhofer Caroline C. , Feng Ming , Mishra Mayank
Published: June 2022

Interactions are diagnosed between a marine heatwave (MHW) event and tropical super cyclone Amphan in the Bay of Bengal. In May 2020, an MHW developed in the Bay of Bengal driven by coupled ocean-atmosphere processes which included shoaling of the mixed layer depth due to reduced wind speed, increased net surface shortwave radiation flux into the ocean, increased upper ocean stratification, and increased sub-surface warming. Ocean temperature, rather than salinity, dominated the stratification that contributed to the MHW development and the subsurface ocean warming that also increased tropical cyclone heat potential. The presence of this strong MHW with sea surface temperature anomalies >2.5°C in the western Bay of Bengal coincided with the cyclone track and facilitated the rapid intensification of tropical cyclone Amphan to a super cyclone in just 24 h. This rapid intensification of a short-lived tropical cyclone, with a lifespan of 5 days over the ocean, is unprecedented in the Bay of Bengal during the pre-monsoon period (March-May). As the cyclone approached landfall in northern India, the wind-induced mixing deepened the mixed layer, cooled the ocean's surface, and reduced sub-surface warming in the bay, resulting in the demise of the MHW. This study provides new perspectives on the interactions between MHWs and tropical cyclones that could aid in improving the current understanding of compound extreme events that have severe socio-economic consequences in affected countries.
Copper-Nanocoated Ultra-Small Cells in Grain Boundaries Inside an Extinct Vent Chimney
Authors: Takamiya Hinako , Kouduka Mariko , Furutani Hitoshi , Mukai Hiroki , Nakagawa Kaoru , Yamamoto Takushi , Kato Shingo , Kodama Yu , Tomioka Naotaka , Ito Motoo , Suzuki Yohey
Published: June 2022

Chemosynthetic organisms flourish around deep-sea hydrothermal vents where energy-rich fluids are emitted from metal sulfide chimneys. However, microbial life hosted in mineral assemblages in extinct chimneys lacking fluid venting remains largely unknown. The interior of extinct chimneys remains anoxic where the percolation of oxygenated seawater is limited within tightly packed metal sulfide grains. Given the scarcity of photosynthetic organics in deep seawater, anaerobic microbes might inhabit the grain boundaries energetically depending on substrates derived from rock-water interactions. In this study, we reported ultra-small cells directly visualized in grain boundaries of CuFeS2 inside an extinct metal sulfide chimney from the southern Mariana Trough. Nanoscale solid analyses reveal that ultra-small cells are coated with Cu2O nanocrystals in grain boundaries enriched with C, N, and P. In situ spectroscopic and spectrometric characterizations demonstrate the distribution of organics with amide groups and a large molecular organic compound in the grain boundaries. We inferred that the ultra-small cells are anaerobes because of the fast dissolution of Cu2O nanocrystals in oxygenated solution. This Cu2O property also excludes the possibility of microbial contamination from ambient seawater during sampling. It is shown by 16S rRNA gene sequence analysis that the chimney interior is dominated by Pacearchaeota known to have anaerobic metabolisms and ultra-small cells. Our results support the potential existence of photosynthesis-independent microbial ecosystems in grain boundaries in submarine metal sulfides deposits on the early Earth.
Greenland Ice Sheet Surfaces Colonized by Microbial Communities Emit Volatile Organic Compounds
Authors: Doting Eva L. , Davie-Martin Cleo L. , Johansen Anders , Benning Liane G. , Tranter Martyn , Rinnan Riikka , Anesio Alexandre M.
Published: June 2022

Volatile organic compounds (VOCs) are emitted by organisms for a range of physiological and ecological reasons. They play an important role in biosphere–atmosphere interactions and contribute to the formation of atmospheric secondary aerosols. The Greenland ice sheet is home to a variety of microbial communities, including highly abundant glacier ice algae, yet nothing is known about the VOCs emitted by glacial communities. For the first time, we present VOC emissions from supraglacial habitats colonized by active microbial communities on the southern Greenland ice sheet during July 2020. Emissions of C5–C30 compounds from bare ice, cryoconite holes, and red snow were collected using a push–pull chamber active sampling system. A total of 92 compounds were detected, yielding mean total VOC emission rates of 3.97 ± 0.70 μg m–2 h–1 from bare ice surfaces (n = 31), 1.63 ± 0.13 μg m–2 h–1 from cryoconite holes (n = 4), and 0.92 ± 0.08 μg m–2 h–1 from red snow (n = 2). No correlations were found between VOC emissions and ice surface algal counts, but a weak positive correlation (r = 0.43, p = 0.015, n = 31) between VOC emission rates from bare ice surfaces and incoming shortwave radiation was found. We propose that this may be due to the stress that high solar irradiance causes in bare ice microbial communities. Acetophenone, benzaldehyde, and phenylmaleic anhydride, all of which have reported antifungal activity, accounted for 51.1 ± 11.7% of emissions from bare ice surfaces, indicating a potential defense strategy against fungal infections. Greenland ice sheet microbial habitats are, hence, potential sources of VOCs that may play a role in supraglacial microbial interactions, as well as local atmospheric chemistry, and merit future research efforts.
Insights Into the Effect of Rice Stripe Virus P2 on Rice Defense by Comparative Proteomic Analysis
Authors: Yang Zihang , Zhang Hehong , Tan Xiaoxiang , Wei Zhongyan , Wen Caiyi , Sun Zongtao , Sun Bingjian , Chen Jianping
Published: June 2022

Rice stripe virus (RSV) has a serious effect on rice production. Our previous research had shown that RSV P2 plays important roles in RSV infection, so in order to further understand the effect of P2 on rice, we used Tandem Mass Tag (TMT) quantitative proteomics experimental system to analyze the changes of protein in transgenic rice expressing P2 for the first time. The results of proteomics showed that a total of 4,767 proteins were identified, including 198 up-regulated proteins and 120 down-regulated proteins. Functional classification results showed that differentially expressed proteins (DEPs) were mainly localized in chloroplasts and mainly involved in the metabolic pathways. Functional enrichment results showed that DEPs are mainly involved in RNA processing and splicing. We also verified the expression of several DEPs at the mRNA level and the interaction of a transcription factor (B7EPB8) with RSV P2. This research is the first time to use proteomics technology to explore the mechanism of RSV infection in rice with the RSV P2 as breakthrough point. Our findings provide valuable information for the study of RSV P2 and RSV infection mechanism.
Isolation, Molecular Characterization, and Antimicrobial Resistance of Selected Culturable Bacteria From Crayfish (Procambarus clarkii)
Authors: Huang Zixian , Li Yuanyuan , Cai Chang , Dong Ning
Published: June 2022

Red swamp crayfish (Procambarus clarkii) have become one of the favorite aquatic products in China. The modern farming mode which uses antibiotics to prevent diseases could impact the bacteria in crayfish intestines. Here, we determined the distribution and antimicrobial resistance phenotypes of the selected culturable bacteria in crayfish intestines and characterized an isolate with last-line antibiotic resistance determinant. Totally, 257 strains were isolated from 115 crayfish. These strains were highly diverse, with Citrobacter sp. (n = 94, 36.6%) and Aeromonas sp. (n = 88, 34.2%) being dominant. Other isolates belonged to genera Pseudomonas, Myroides, Morganella, Klebsiella, Acinetobacter, Proteus, Enterobacter, Kluyvera, and Escherichia. Most strains from crayfish were susceptible to all tested antibiotics. None of the isolates carried last-line antibiotic resistance genes except one Escherichia coli isolate with blaNDM-5 was detected, which is the first report of blaNDM-5-positive E. coli isolate from red swamp crayfish. Whole-genome sequencing suggested it belonged to ST48 and carried several resistance genes. blaNDM-5 was located within an Tn3000-like transposon linked to an external 5 bp sequence (ACTAT) on both sides on a IncHI1B/HI1A/FIA multi-replicon plasmid. This transposon was considered to be acquired by replicative transposition mediated by IS3000. The emergence of bacteria with last-line antibiotic resistance genes in crayfish poses serious threat to public health since crayfish could act as a reservoir for the transfer of resistance to humans.
Plasma Levels of Tissue-Type Plasminogen Activator (tPA) in Normal Aging and Alzheimer's Disease: Links With Cognition, Brain Structure, Brain Function and Amyloid Burden
Authors: Tomadesso Clémence , de Lizarrondo Sara Martinez , Ali Carine , Landeau Brigitte , Mézenge Florence , Perrotin Audrey , de La Sayette Vincent , Vivien Denis , Chételat Gaël
Published: June 2022

Tissue-type plasminogen activator (tPA) is a protease known for its fibrinolytic action but is also involved in physiological and pathophysiological aging processes; including amyloid elimination and synaptic plasticity. The aim of the study was to investigate the role of tPA in cognitive and brain aging. Therefore, we assessed the links between tPA plasma concentration and cognition, structural MRI, FDG-PET and Flobetapir-PET neuroimaging in 155 cognitively unimpaired adults (CUA, aged 20-85 years old) and 32 patients with Alzheimer's disease (ALZ). A positive correlation was found between tPA and age in CUA (p < 0.001), with males showing higher tPA than females (p = 0.05). No significant difference was found between ALZ patients and cognitively unimpaired elders (CUE). Plasma tPA in CUA negatively correlated with global brain volume. No correlation was found with brain FDG metabolism or amyloid deposition. Age-related tPA changes were associated to changes in blood pressure, glycemia and body mass index. Within the ALZ patients, tPA didn't correlate with any cognitive or neuroimaging measures, but only with physiological measures. Altogether our study suggests that increased tPA plasma concentration with age is related to neuronal alterations and cardiovascular risk factors.
Social Network Plasticity of Mice Parental Behavior
Authors: Orikasa Chitose
Published: June 2022

Neural plasticity occurs during developmental stages and is essential for sexual differentiation of the brain and the ensuing sex-dependent behavioral changes in adults. Maternal behavior is primarily affected by sex-related differences in the brain; however, chronic social isolation even in mature male mice can induce maternal retrieving and crouching behavior when they are first exposed to pups. Social milieus influence the inherent behavior of adults and alter the molecular architecture in the brain, thereby allowing higher levels of associated gene expression and molecular activity. This review explores the possibility that although the development of neural circuits is closely associated with maternal behavior, the brain can still retain its neuroplasticity in adults from a neuromolecular perspective. In addition, neuronal machinery such as neurotransmitters and neuropeptides might influence sociobehavioral changes. This review also discusses that the neural circuits regulating behaviors such as parenting and infanticide (including neglect behavior), might be controlled by neural relay on melanin concentrating hormone (MCH)–oxytocin in the hypothalamus during the positive and negative mode of action in maternal behavior. Furthermore, MCH–oxytocin neural relay might contribute to the anxiolytic effect on maternal behavior, which is involved with reward circuits.
Rodent Modeling of Alzheimer's Disease in Down Syndrome: In vivo and ex vivo Approaches
Authors: Farrell Clíona , Mumford Paige , Wiseman Frances K.
Published: June 2022

There are an estimated 6 million people with Down syndrome (DS) worldwide. In developed countries, the vast majority of these individuals will develop Alzheimer's disease neuropathology characterized by the accumulation of amyloid-β (Aβ) plaques and tau neurofibrillary tangles within the brain, which leads to the early onset of dementia (AD-DS) and reduced life-expectancy. The mean age of onset of clinical dementia is ~55 years and by the age of 80, approaching 100% of individuals with DS will have a dementia diagnosis. DS is caused by trisomy of chromosome 21 (Hsa21) thus an additional copy of a gene(s) on the chromosome must cause the development of AD neuropathology and dementia. Indeed, triplication of the gene APP which encodes the amyloid precursor protein is sufficient and necessary for early onset AD (EOAD), both in people who have and do not have DS. However, triplication of other genes on Hsa21 leads to profound differences in neurodevelopment resulting in intellectual disability, elevated incidence of epilepsy and perturbations to the immune system. This different biology may impact on how AD neuropathology and dementia develops in people who have DS. Indeed, genes on Hsa21 other than APP when in three-copies can modulate AD-pathogenesis in mouse preclinical models. Understanding this biology better is critical to inform drug selection for AD prevention and therapy trials for people who have DS. Here we will review rodent preclinical models of AD-DS and how these can be used for both in vivo and ex vivo (cultured cells and organotypic slice cultures) studies to understand the mechanisms that contribute to the early development of AD in people who have DS and test the utility of treatments to prevent or delay the development of disease.
Associations Between Physical Activity and Alcohol Consumption in Rural Cancer Survivors
Authors: Mama Scherezade K. , Heredia Natalia I. , Johnston Hannah , Conroy David E.
Published: June 2022

Purpose

Rural adults and cancer survivors are more likely to be physically inactive and exceed recommendations for alcohol use. Physical activity and alcohol use are positively associated in adults and cancer survivors but associations between physical activity and alcohol use in rural cancer survivors is unknown. This cross-sectional study explored associations between physical activity, sitting time, and alcohol use in rural cancer survivors.

Methods

Cancer survivors residing in central Pennsylvania were recruited to the Partnering to Prevent and Control Cancer (PPCC) study and completed mailed questionnaires assessing physical activity (low, moderate, high), sitting time (<6 or ≥6 hours/day), and alcohol use (0 or ≥1 drinks/week). Binary logistic regression models tested associations between physical activity, sitting time, and alcohol use, adjusting for age, gender, and education.

Results

Participants (N=219) were in their mid-60s (M age=64.5 ± 12.2 years, 60.7% female), overweight (M BMI=29.6 ± 6.9 kg/m2), and 50.5% were college graduates. Nearly half of participants were breast (22.8%) or prostate (20.5%) cancer survivors and 90.4% were >12 weeks but <5 years post-treatment. Participants self-reported meeting physical activity recommendations (79.5%), sitting <6 hours/day (53.3%), and consuming ≥1 alcoholic drinks/week (54.1%). Participants who reported being moderately (OR=5.0, 95% CI: 1.9-12.9) or highly (OR=4.5, 95% CI: 1.9-10.9) active had higher odds of reporting alcohol use, after adjusting for covariates.

Conclusion

Results mirror positive associations seen in adults and other subgroups (e.g., racial/ethnic minority adults). Cancer control efforts should stress being physically active while emphasizing messaging to curtail increases in alcohol use among rural cancer survivors.
Chidamide Maintenance Therapy Following Induction Therapy in Patients With Peripheral T-Cell Lymphoma Who Are Ineligible for Autologous Stem Cell Transplantation: Case Series From China
Authors: Guo Wei , Wang Xingtong , Li Jia , Yin Xianying , Zhao Yangzhi , Tang Yang , Wang Anna , Bai Ou
Published: June 2022

Objective

To assess the potential benefit of chidamide maintenance therapy after induction treatment in peripheral T-cell lymphoma (PTCL).

Materials and Methods

The clinical data of 48 transplantation-ineligible patients with different PTCL subtypes who received continuous chidamide treatment after first-line therapy were collected. Progression-free survival (PFS), overall survival (OS), and safety were analyzed.

Results

In total, 68.8% of patients were male (33/48), the median age was 59.5 years (22~80). The pathological subtypes were angioimmunoblastic T-cell lymphoma (AITL, 43.8%), anaplastic large cell lymphoma (ALCL, 16.6%), PTCL-not otherwise specified (NOS, 25%), NK/T-cell lymphoma (NKT, 14.6%). 35.4% (7/48) patients had intermediate or high risk (IPI=3~5). 20 patients (41.7%) received chidamide as a maintenance treatment after achieving a complete response (CR). 57.1% (16/28) exhibited a better response after chidamide (9 cases partial response [PR] to CR, 7 from stable disease [SD] to PR). The CR and overall response rate (ORR) were 60.4% and 93.8%, respectively. In addition, 21/21 AITL, 10/12 PTCL-NOS, and 8/8 ALCL, 6/7 NK/T exhibited CR/PR as the best response during the follow-up period. Meanwhile, the CR and ORR did not differ by age (<60 vs ≥60: 50.0% vs 70.8%, P = 0.091; and 91.7% vs 95.8%, P = 0.551). The median follow-up period was 12.8 months (3.0–66.6), 14 patients developed PD (29.2%), 10 of them died of lymphoma (20.8%). Totally, the 40 cases achieved CR/PR from 1st line regimen got better PFS as well as OS than the rest 8 cases (the 1-year PFS was 80.8% vs 46.9% and the 2-year PFS was 71.9% vs 46.9%, P=0.012. the 1-year OS was 89.9% vs 72.6% and the 2-year OS was 85.9% vs 48.6%, P=0.032). No patients discontinued treatment because of adverse events. The most common toxicities were neutropenia (75.0%), anemia (79.2%), thrombocytopenia (58.3%), and anorexia (45.8%), and fatigue (43.8%).

Conclusion

Chidamide maintenance therapy led to improvements of PFS and OS with a manageable safety profile in patients with PTCL. Further randomized studies are required to examine the role of chidamide maintenance therapy in PTCL.
Imaging and Clinicopathological Features of Acinar Cell Carcinoma
Authors: Qu Qianqian , Xin Yinghui , Xu Yifan , Yuan Yao , Deng Kai
Published: June 2022

Background

Acinar cell carcinoma (ACC) is a rare pancreatic epithelial malignancy that poses a significant threat. However, there are few related clinical studies. The present study aimed to analyze the imaging and pathological features of ACC to provide a reference for better diagnosis and treatment planning.

Methods

Thirty-nine with ACC, referred to Qianfoshan Hospital, Qilu Hospital and Provincial Hospital in Shandong Province from December 2012 to December 2020, were enrolled. Their imaging and clinicopathological features were analyzed. They were followed up for 1 year, and Cox regression was used to analyze the factors affecting patient prognosis.

Results

ACC was more common in the middle-aged and elderly and peaked at approximately 60 years. The clinical manifestations of the patients were mostly flatulence and upper abdomen pain. The tumor was located in the head of the pancreas in 19 cases, with an average size of 5.8 cm. We found nerve invasion and liver metastasis in one case each. 8 patients showed irregular amorphous tumor calcification on plain computed tomography and 5 showed high and low signals on T1- and T2-weighted images, respectively. Immunohistochemistry revealed 100.0% positive rates for CK, β-catenin, and Ki-67. Thirty-three patients underwent surgical resection, and the 2-year overall mortality rate was 25.6%. Cox analysis revealed that smoking was an independent risk factor affecting patient prognosis.

Conclusion

An in-depth understanding of the imaging and clinicopathological features of ACC is conducive to better diagnosis and treatment planning for ACC and subsequent improvement in patient prognosis.
The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification
Authors: Cheng Tiffany W. , Ahern Madeline C. , Giubellino Alessio
Published: June 2022

Spitz tumors represent a distinct subtype of melanocytic lesions with characteristic histopathologic features, some of which are overlapping with melanoma. More common in the pediatric and younger population, they can be clinically suspected by recognizing specific patterns on dermatoscopic examination, and several subtypes have been described. We now classify these lesions into benign Spitz nevi, intermediate lesions identified as “atypical Spitz tumors” (or Spitz melanocytoma) and malignant Spitz melanoma. More recently a large body of work has uncovered the molecular underpinning of Spitz tumors, including mutations in the HRAS gene and several gene fusions involving several protein kinases. Here we present an overarching view of our current knowledge and understanding of Spitz tumors, detailing clinical, histopathological and molecular features characteristic of these lesions.
Development, Validation, and Comparison of Image-Based, Clinical Feature-Based and Fusion Artificial Intelligence Diagnostic Models in Differentiating Benign and Malignant Pulmonary Ground-Glass Nodules
Authors: Wang Xiang , Gao Man , Xie Jicai , Deng Yanfang , Tu Wenting , Yang Hua , Liang Shuang , Xu Panlong , Zhang Mingzi , Lu Yang , Fu ChiCheng , Li Qiong , Fan Li , Liu Shiyuan
Published: June 2022

Objective

This study aimed to develop effective artificial intelligence (AI) diagnostic models based on CT images of pulmonary nodules only, on descriptional and quantitative clinical or image features, or on a combination of both to differentiate benign and malignant ground-glass nodules (GGNs) to assist in the determination of surgical intervention.

Methods

Our study included a total of 867 nodules (benign nodules: 112; malignant nodules: 755) with postoperative pathological diagnoses from two centers. For the diagnostic models to discriminate between benign and malignant GGNs, we adopted three different artificial intelligence (AI) approaches: a) an image-based deep learning approach to build a deep neural network (DNN); b) a clinical feature-based machine learning approach based on the clinical and image features of nodules; c) a fusion diagnostic model integrating the original images and the clinical and image features. The performance of the models was evaluated on an internal test dataset (the “Changzheng Dataset”) and an independent test dataset collected from an external institute (the “Longyan Dataset”). In addition, the performance of automatic diagnostic models was compared with that of manual evaluations by two radiologists on the ‘Longyan dataset’.

Results

The image-based deep learning model achieved an appealing diagnostic performance, yielding AUC values of 0.75 (95% confidence interval [CI]: 0.62, 0.89) and 0.76 (95% CI: 0.61, 0.90), respectively, on both the Changzheng and Longyan datasets. The clinical feature-based machine learning model performed well on the Changzheng dataset (AUC, 0.80 [95% CI: 0.64, 0.96]), whereas it performed poorly on the Longyan dataset (AUC, 0.62 [95% CI: 0.42, 0.83]). The fusion diagnostic model achieved the best performance on both the Changzheng dataset (AUC, 0.82 [95% CI: 0.71-0.93]) and the Longyan dataset (AUC, 0.83 [95% CI: 0.70-0.96]), and it achieved a better specificity (0.69) than the radiologists (0.33-0.44) on the Longyan dataset.

Conclusion

The deep learning models, including both the image-based deep learning model and the fusion model, have the ability to assist radiologists in differentiating between benign and malignant nodules for the precise management of patients with GGNs.
Longitudinal Correlations Between Intravoxel Incoherent Motion (IVIM) and Dynamic Contrast-Enhanced (DCE) MRI During Radiotherapy in Prostate Cancer Patients
Authors: Kooreman Ernst S. , van Pelt Vivian , Nowee Marlies E. , Pos Floris , van der Heide Uulke A. , van Houdt Petra J.
Published: June 2022

Purpose

Intravoxel incoherent motion (IVIM) is a promising technique that can acquire perfusion information without the use of contrast agent, contrary to the more established dynamic contrast-enhanced (DCE) technique. This is of interest for treatment response monitoring, where patients can be imaged on each treatment fraction. In this study, longitudinal correlations between IVIM- and DCE parameters were assessed in prostate cancer patients receiving radiation treatment.

Materials and Methods

20 prostate cancer patients were treated on a 1.5 T MR-linac with 20 x 3 or 3.1 Gy. Weekly IVIM and DCE scans were acquired. Tumors, the peripheral zone (PZ), and the transition zone (TZ) were delineated on a T2-weighted scan acquired on the first fraction. IVIM and DCE scans were registered to this scan and the delineations were propagated. Median values from these delineations were used for further analysis. The IVIM parameters D, f, D* and the product fD* were calculated. The Tofts model was used to calculate the DCE parameters Ktrans, kep and ve. Pearson correlations were calculated for the IVIM and DCE parameters on values from the first fraction for each region of interest (ROI). For longitudinal analysis, the repeated measures correlation coefficient was used to determine correlations between IVIM and DCE parameters in each ROI.

Results

When averaging over patients, an increase during treatment in all IVIM and DCE parameters was observed in all ROIs, except for D in the PZ and TZ. No significant Pearson correlations were found between any pair of IVIM and DCE parameters measured on the first fraction. Significant but low longitudinal correlations were found for some combinations of IVIM and DCE parameters in the PZ and TZ, while no significant longitudinal correlations were found in the tumor. Notably in the TZ, for both f and fD*, significant longitudinal correlations with all DCE parameters were found.

Conclusions

The increase in IVIM- and DCE parameters when averaging over patients indicates a measurable response to radiation treatment with both techniques. Although low, significant longitudinal correlations were found which suggests that IVIM could potentially be used as an alternative to DCE for treatment response monitoring.
Epigenetic Regulation in Gastroenteropancreatic Neuroendocrine Tumors
Authors: Crabtree Judy S.
Published: June 2022

Gastroenteropancreatic neuroendocrine neoplasms are a rare, diverse group of neuroendocrine tumors that form in the pancreatic and gastrointestinal tract, and often present with side effects due to hormone hypersecretion. The pathogenesis of these tumors is known to be linked to several genetic disorders, but sporadic tumors occur due to dysregulation of additional genes that regulate proliferation and metastasis, but also the epigenome. Epigenetic regulation in these tumors includes DNA methylation, chromatin remodeling and regulation by noncoding RNAs. Several large studies demonstrate the identification of epigenetic signatures that may serve as biomarkers, and others identify innovative, epigenetics-based targets that utilize both pharmacological and theranostic approaches towards the development of new treatment approaches.
Mortality Rate of Lymphoma in China, 2013–2020
Authors: Liu Weiping , Qi Jinlei , Liu Jiangmei , Song Yuqin , Wang Lijun , Zhou Maigeng , Ma Jun , Zhu Jun
Published: June 2022

Lymphoma is a malignant disease that threatens human health and imposes a significant burden on the society burden; however, there are limited accurate mortality data on lymphoma in China. The present study aimed to analyse lymphoma-associated mortality at the national and provincial levels in mainland China. Mortality data of lymphoma was extracted from the disease surveillance system of the Chinese Center for Disease Control and Prevention. Mortality was represented by the number of deaths, crude mortality rate, and age-standardized mortality rate. Temporal trends in mortality rates were examined using the fitting joinpoint models. Lymphoma accounted for 31,225 deaths in 2020, of which 1,838 and 29,387 were due to Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL), respectively. The age-standardized mortality rate per 100,000 population was 1.76 for lymphoma, 0.10 for HL, and 1.66 for NHL. The mortality rate increased with age, reaching a peak in the age group of 80–84 years for HL and over 85 years for NHL. Moreover, the death risk due to lymphoma was approximately 1.5–2 times greater in males than in females in all age groups. The mortality rate was higher in eastern China than in central and western China, indicating a heterogeneous distribution at the provincial level. During 2013–2020, the mortality rate of lymphoma decreased by 1.85% (−22.94% for HL and −0.14% for NHL). In conclusion, the mortality of lymphoma varied by sex, age, and regions, which highlighted the need of establish differentiated strategy for disease control and prevention.