bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Validation of MRI Radiomics Model for Predicting Perineural Invasion in Rectal Cancer
Authors: Cao Zhengyu , Yang Tiejun , Gong Wanfeng , Wang Jiahui , Fu Weiqi , Yang Dengfa , Guo Yuwen
Published: January 2025

Background
This study aims to explore the application of multiparametric MRI (mp-MRI) based radiomics in evaluating the perineural invasion (PNI) status of rectal cancer.
Methods
A retrospective analysis was conducted on clinical and MRI data from 423 rectal cancer patients confirmed by surgical pathology across two centers. A total of 343 patients from Center 1 were split into a training set and an internal validation (in-vad) set in an 8:2 ratio, while 80 patients from Center 2 served as an independent external validation (ex-vad) set. Univariate and multivariate analyses were performed on clinical features to construct a clinical model. Radiomic features were extracted using Pyradiomics software, and features were selected and reduced using mRMR and LASSO methods to construct the radiomics model. A combined model integrating clinical and radiomics features was subsequently built, and a nomogram was developed.
Results
Among all patients, 131 cases (31.0%) were PNI-positive. Multivariate analysis identified mrT (OR = 1.038, P < 0.001) and mrN (OR = 1.038, P < 0.001) as independent predictors of PNI, forming the clinical model. After radiomic feature selection, 30 features were used to build the radiomics model. The area under the curve (AUC) values for the clinical model in the training, in-vad, and ex-vad sets were 0.719, 0.631, and 0.760, respectively. The AUC values for the radiomics model were 0.841, 0.815, and 0.916, while those for the combined model were 0.899, 0.826, and 0.914. The Delong test demonstrated that both the radiomics and combined models outperformed the clinical model across all datasets, with no statistically significant difference between the radiomics and combined models.
Conclusions
The mp-MRI based radiomics model effectively predicts PNI status in rectal cancer, providing a non-invasive and accurate method for preoperative evaluation.
Neuroendoscopic Management for Right Epileptogenic Hypothalamic Hamartoma
Authors: Cavalheiro Sergio , Quiróz José Antonio Rangel , Dastoli Patricia Alessandra , Kim Isaque Hyung Tong , Suzuki Fernando Seiji , Costa Marcos Devanir Silva da
Published: January 2025

Hypothalamic hamartomas are congenital hypothalamus lesions that usually cause refractory seizures, endocrinological disturbances, cognitive decline, and psychiatric symptoms.
Magnetic resonance imaging of the brain with and without contrast agent is the gold standard for diagnosis.
Surgery is generally indicated when medication-refractory seizures occur.
We present the case of a 4-year-old boy with epilepsy refractory to anticonvulsant medications where magnetic resonance imaging revealed a lesion at the level of the right mammillary body.
We present endoscopic resection of the right hamartoma, which improved the patient’s seizures (Engel I) without neurological complications in his postoperative images and without complications in his postoperative images.
Differential Impact of Maternal and Paternal Metabolic Syndrome on Offspring’s Cardiometabolic Risk Factors
Authors: Park Jun-Hong , Cho Min Hyung , Shim Young Suk , Lee Hae Sang
Published: January 2025

This study compared the sex-specific influence of maternal and paternal metabolic syndrome on offspring using the 2007–2020 Korean National Health and Nutritional Examination Survey database. As a result, male offspring of fathers with metabolic syndrome presented increased blood glucose levels and unfavorable lipid profiles, whereas female offspring presented increased blood pressure, increased triglyceride levels, and decreased HDL cholesterol levels. Maternal metabolic syndrome was associated with adverse lipid profiles in offspring of both sexes, along with increased blood pressure in males and increased waist circumference and systolic blood pressure in females. When both parents had metabolic syndrome, the adjusted odds ratios for metabolic syndrome and most of its components were significantly elevated for male offspring. Conversely, female offspring exhibited relatively less elevated odds ratios of the metabolic syndrome. The disparate transgenerational impact on metabolic health by sexes emphasizes the need for sex-specific screening and management strategies for families with metabolic syndrome.
Construction of a Small-Scale Vacuum Generation System and Using It as an Educational Device to Demonstrate Features of the Vacuum
Authors: Marzouk Osama A. , Jul Walid Ali Marjan Haje Rhaim , Jabri Amjad Masoud Khalfan Al , Al-ghaithi Hamed Aamir Mohammed Aamir
Published: January 2025

We developed a vacuum generation system composed of a reciprocating compressor (3 tons of refrigeration) with an inverted-function that is ready to be hooked flexibly to a gas-tight container to create an evacuated enclosed atmosphere, without strict limitation of the size of that container. The evacuated container (or vacuum chamber) can serve in different purposes such as educational demonstration of the vacuum properties, extraction of perfumes from herbal resources, and preserving food. We tested the device and found it can reach a vacuum level of 26 inches of mercury in an environment with an atmospheric pressure of 28.5 inches of mercury. We compared the performance of our vacuum device to a rotary-vane vacuum pump of ¼ horsepowers and found that the vacuum pump reaches a set test vacuum level of 25 inches of mercury before the compressor. We then demonstrated experimentally some features of the vacuum using the inverted compressor or the vane vacuum pump. These experiments serve some topics in physics for school students as well as two core subjects of mechanical engineering, namely fluid mechanics and thermodynamics.
Shaking table test on compacted soil to reduce liquefaction potential
Authors: Rachman Asmar Muhammad Fhathur , Harimurti Harimurti , Zaika Yulvi
Published: January 2025

Liquefaction is a granular soil material from a solid state to a liquid an increase in pore water pressure and a decrease in its effective stress. Liquefaction can cause loss of soil bearing capacity, damaging the construction above it. A simple shaking Table using a one-way vibrating Table is the tool used in this study. The earthquake accelerations used in this study are 0,3 g and 0,5 g earthquake accelerations repair method carried out in the form of compaction. Before the shaking Table test is carried out, laboratory tests are first carried out to determine the soil classification. the soil classification used in this study is SM. The purpose of this research is to determine the time of liquefaction on variations in grain size gradation and density on sand soil liquefaction with different earthquake acceleration. Based on the test results, poorly graded soil is the fastest to deformed. In 0,3 g earthquake acceleration performed total settlement of 10 mm at 100 seconds and a groundwater level in 7 mm at 15 seconds. An acceleration of 0,5 g performed total settlement of 12 mm at 10 seconds and a groundwater level in 7 mm at 15 seconds. The poorly graded soil is improved by compaction. The compacted soil in density of 17,838 kN/m3 performed settlement of 8 mm at 105 seconds and a groundwater level in 6 mm at 40 seconds in 0,3 g earthquake acceleration. The compacted soil in density of 17,995 kN/m3 performed 8 mm at 100 seconds and groundwater level in 7 mm at 20 seconds in 0,5 g earthquake acceleration. The compacted soil in density of 18,563 kN/m3 performed settlement 6 mm at the 100th second and a groundwater level 6 mm at the 25th second in 0,5 g earthquake acceleration. Based on the research results, compaction can reduce liquefaction potential
Combustion characteristics of Biosolar B20 fuel enhanced with clove oil (syzygium aromaticum) bioadditives
Authors: Subagyo Rachmat , Tamjidillah Mastiadi , Nugraha Andy , Anggono Atma Cahyo , Sukoco Krisna Enos , Permana Arya Fatia , Andriati Maria
Published: January 2025

This study focuses on improving the combustion characteristics of Biodiesel B20 fuel by adding clove oil (Syzygium aromaticum) as a bioadditive. The main issues addressed are improving combustion efficiency and reducing emissions, which are crucial for advancing sustainable biodiesel solutions. This study investigated the effects of varying concentrations of clove oil (1–5 ml) on key combustion parameters such as ignition delay, combustion duration, peak temperature, and emissions.
The experimental results showed that adding clove oil to Biodiesel B20 significantly reduced the ignition delay and combustion duration, indicating improved combustion efficiency. In addition, the peak temperature was higher for the fuel blend with clove oil, indicating improved thermal performance. Emission analysis revealed a decrease in harmful emissions, supporting the environmental benefits of clove oil bioadditive.
These findings are explained by the high eugenol content in clove oil, which facilitates better combustion due to its oxygenated compounds. The reduction in ignition delay and combustion duration, along with the increase in peak temperature, indicates more efficient and complete combustion.
The results showed that clove oil bioadditive can improve the performance of Biodiesel B20 by increasing combustion efficiency and reducing emissions. These features make clove oil a viable bioadditive for developing more efficient and environmentally friendly biodiesel blends. The practical use of these findings is relevant for biodiesel producers and environmental policy makers aiming to promote sustainable energy solutions. The results contribute to the optimization of biodiesel formulations, supporting the global transition to renewable energy sources
Aspectos determinantes de la inteligencia artificial en la investigación educativa
Authors: Molina Isaza Liliana Esther
Published: January 2025

Actualmente, la Inteligencia Artificial (IA) incide en los procesos educativos; por ello, es objeto de estudio de la investigación educativa (IE). Desde esta perspectiva, se realizó un análisis documental, mediante la técnica de revisión de contenido: tesis de maestrías o doctorales, artículos de revistas y libros pertenecientes a distintas bases de datos, como Latindex, Redalcy, Scielo, Dialnet y buscadores como Consensus y Google Académico, con el fin de estudiar los aspectos determinantes de la IA en la investigación educativa, propiciando la construcción de nuevos conocimientos, que estructurarán teóricamente a futuras investigaciones siendo relevante para la comunidad científica. Entre sus resultados se destaca que el concepto de IA, que es complejo y ha evolucionado con el tiempo, la IA aporta tanto a la educación como al proceso metodológico investigativo, planteando desafíos a la investigación educativa, los cuales se direccionan de acuerdo con los siguientes criterios: 1. Importancia de la IA para la educación y cumplimiento del cuarto objetivo de desarrollo sostenible (ODS); 2. Limitantes en la formación del docente investigador en IA; 3. Consideraciones éticas por el uso de IA en la escritura y otras actividades científicas; 4. Problemas emergentes por la utilización de IA en educación.
Memories of the collective action of teachers' networks and collectives in Latin America
Authors: Díaz Becerra Lizeth Marcela
Published: January 2025

Teachers' networks and collectives have been consolidated as spaces for self-management of contextualized pedagogical practices with a view to building hopeful projects for the country based on other ways of being a teacher and doing school. From this perspective, it was proposed to analyze the emerging notions of teachers' networks and collectives and the pillars of the micropolitics of collective action. Methodologically, a documentary review of theoretical and conceptual references on teachers' networks and collectives in Latin America, being these, the collective subject of study. It was found that the dialogue of knowledge, the critical analysis of educational policies, the self- reflection of practice and contexts, generate other pedagogical practices that reflect the changes at epistemic, pedagogical, axiological, social, political and educational levels that teachers in networks have. The above, within the development of the theoretical framework of the doctoral research Emancipatory Pedagogical Practices of networks and collectives of teachers in Latin America, advised by Dr. Maria Cristina Martinez of the research group Education and Political Culture of the emphasis of Education, Culture and Society of the Interinstitutional Doctorate in Education of the National Pedagogical University of Colombia.
Podstawy obecności duchownych w mediach. Aspekt teologiczny i kanoniczny
Authors: Kołodziej Marcin
Published: January 2025

Kościół realizuje Chrystusowy nakaz głoszenia Ewangelii także poprzez środki społecznego przekazu. Zwrócił na to uwagę w czasach najnowszych Sobór Watykański II, który w dekrecie Inter mirifica, postulował korzystanie z tych narzędzi. W obecnym czasie ważną przestrzenią przepowiadania słowa Bożego stał się również internet. Obecność duchownych w mediach społecznościowych wydaje się być konieczna. Ma ona oczywiście swoje blaski i cienie. Dlatego w refleksji teologicznej i ustawodawstwie posoborowym Kościoła nie brakuje wskazań, które posługę duchownych w mediach mają uporządkować w taki sposób, aby stała się ona nowoczesną amboną i służyła skutecznemu przepowiadaniu słowa Bożego.
Recent Advancements in Drug Targeting for Ferroptosis as an Antitumor Therapy: Development of Novel therapeutics
Authors: Negi Reena Rawat , Singh Sanju , Gupta Neeta , Upadhyay Manish , Shrivastava Shilpi , Jain Bhawana
Published: January 2025

Objectives:

The primary objective of this review is to provide updated mechanisms that regulate ferroptosis sensitivity in cancer cells and recent advancements in drug targeting for ferroptosis as an antitumor therapy.

Methods:

To achieve these objectives, a comprehensive literature review was conducted, ana-lyzing recent studies on ferroptosis, including its cellular, molecular, and gene-level character-istics. The review involved an evaluation of advancements in ferroptosis drug research across various medical domains, with particular attention to novel therapeutic approaches in nano-medicine, TCM, and Western medicine. The review also included an assessment of how fer-roptosis influences cancer treatment, including its role in tumor drug resistance and immuno-therapy, and provided a detailed analysis of pharmacological activators of ferroptosis.

Results:

The review highlights several key findings, like primary mechanisms that regulate cancer cell sensitivity to ferroptosis, and provides an overview of the latest advancements in ferroptosis drug research. The review reveals that ferroptosis has both beneficial and detri-mental effects on human cancer, reflecting its complex role in cancer progression and treat-ment. The review also emphasizes the dual nature of ferroptosis, noting its potential as both a tumor suppressor and an oncogenic factor. Additionally, it provides a comprehensive exami-nation of various pharmacological agents that activate ferroptosis and their potential therapeu-tic applications.

Conclusion:

In conclusion, ferroptosis represents a promising target for cancer therapy, given its distinctive characteristics and significant role in tumor biology. The review underscores the need for further research to clarify the complex roles of ferroptosis in carcinogenesis and to optimize the development of novel therapeutics targeting this form of cell death. It also high-lights current challenges and opportunities in the field, including the potential for overcoming cancer metastasis through ferroptosis modulation and the need for continued exploration of pharmacological activators to advance therapeutic strategies.
Rhabdomyolysis Following Trimethoprim-Sulfamethoxazole Therapy: A Case Report and Review of the Literature
Authors: Salem Mahjoubi Yasmine , Fatma Zgolli , Israa Dahmani , Widd Kaabi , Sarrah Kastalli , Imen Aouinti , Sihem El Aidli
Published: January 2025

Background:

Trimethoprim-Sulfamethoxazole (TMP-SMX) is a commonly used antibiotic
for the treatment of several infections, such as urinary tract infections, respiratory infections,
and in certain cases, septic arthritis. Rhabdomyolysis (RM) is very rare and less than 20
cases have been reported, so far, in the literature, in particular in immunocompromised patients.
Here, we report a case of TMP-SMX-induced RM in an immunocompetent patient, adding to the
limited data on this association.

Case Presentation:

A 53-year-old male patient with no prior medical history presented with septic
arthritis and was initiated on TMP-SMX therapy. Within days, he developed muscle pain and
weakness with laboratory tests revealing markedly elevated Creatine Kinase (CK) levels, consistent
with rhabdomyolysis. Following the discontinuation of TMP-SMX, the patient’s CK levels
gradually decreased, and his symptoms resolved without further intervention.

Conclusion:

To our knowledge, this is the sixth reported case of TMP-SMX-associated rhabdomyolysis
in an immunocompetent patient. This case highlights the need for clinicians to consider
the potential for rhabdomyolysis in patients receiving TMP-SMX, regardless of their immune
status, and to recognize that prompt withdrawal of the drug is critical for patient recovery.
Sustainable Heterogeneous Catalyst Exert for Synthesis of Bio-active
Pyrano[2,3-c]pyrazole Scaffolds as an Anticancer and Antimicrobial Drug
Agents
Authors: Karmakar Rajiv , Rana Soumitra , Mukhopadhyay Chhanda
Published: January 2025

Heterocyclic chemistry is an essential area of study in organic chemistry, especially due
to the biological and pharmacological importance of heterocyclic compounds. Developing sustainable, heterogeneous catalysts for the efficient, eco-friendly synthesis of pyrano[2,3-c]pyrazole scaffolds is a key objective in modern synthesis. These N/O-containing fused five-six membered rings
have unique structures and bioactivities that make them promising candidates for use in antimicrobial and anticancer drug development. This review explores the role of heterogeneous catalysis in synthesizing bio-active pyrano[2,3-c]pyrazoles through one-pot, cyclocondensation, and multicomponent reactions, emphasizing their significance in drug development.
The Hemostatic Effects of a Novel Gelatin Sponge Containing Aloe Vera Nanoparticles in Rat Animal Model
Authors: Panahi Paniz , Ghavimi Mohammad Ali , Zandesh Amir , Nasiri Islam , Javaheripour Ailar , Dizaj Solmaz Maleki , Sharifi Simin
Published: January 2025

Introduction:

Biodegradable hemostat sponges are new materials in dentistry that are
used to quickly stop blood after tooth extraction. The purpose of this study was to investigate the
hemostatic effects of a new gelatin sponge containing aloe vera nanoparticles in a rat animal model.

Methods:

For this purpose, twenty-seven adult Wistar rats were purchased. The animals were divided
into three groups test, negative control, and positive control (n=9). Rats were anesthetized
with ketamine and xylazine. A small incision was made on the femoral artery and 100 mg of the
tested hemostat was pressed on it and the coagulation time was recorded with a stopwatch. A commercial
gelatin sponge without aloe vera nanoparticles was considered as a positive control group.
In the negative control group, no substance was used and the normal coagulation time was recorded.
The comparison of the mean values between the studied groups was done with the Kruskal-
Wallis test. SPSS Statistics 25.0 software was used for data analysis with a p-value less than a predetermined
significance level (0.05).

Results:

The new hemostat sponge had a faster blood clotting time than both positive and negative
control groups (P=0.04). Blood clotting time was 17.6 ± 1.0 s for the test group, 210 ± 0.86 s for
the negative control group, and 20 ± 1.2 s for the positive control group.

Conclusion:

The new gelatin sponge containing aloe vera nanoparticles can be used to control
bleeding during surgery or tooth extraction.
Setting the Readiness of Law to Implement Central Bank Digital Currency in Indonesia
Authors: Suwardiyati Rumi , Ahmad Azlin Alisa , Dewantara Reka , Satria Dwi Benny , Ganindha Ranitya
Published: January 2025

The shift in behaviour from conventional to technology-based patterns has led to technological transformation, giving rise to an emerging digital currency: crypto. Crypto assets have great potential to develop financial system inclusion and efficiency while it can pose various risks affecting economic, monetary and financial system stability. The Indonesian government's strategic step to curb the use of cryptocurrencies is to issue Central Bank Digital Currency (CBDC). To date, 109 countries have begun to adopt the use of CBDC. The adoption of CBDC in Indonesia has not yet reached the implementation stage, but is still at the research stage. In line with this, this research aims to examine the readiness of Indonesian law to welcome the enactment of CBDC and to prepare an ideal legal construction in regulating CBDC in Indonesia. This paper employs a normative juridical research method with statutory and comparative approaches. The statutory approach involves examining the norms relating to CBDC, while the comparative approach aims to compare the norms applicable in China and the Bahamas regarding the use of CBDC. The results of this study reveal that the Indonesian government's legal readiness to implement CBDC will begin to enter the experimental stage after the P2SK Law recognises CBDC as a legal payment instrument and BI as the authority authorised to manage CBDC in Indonesia. The results of the comparison with China and the Bahamas show that the determination of the CBDC distribution model and the technology used is an important aspect that needs to be considered in preparing the ideal legal construction because it relates to the technological access capabilities of the community to use CBDC.
Distinguishing Common Parameters for Monitoring and Predicting Depression via Digital Tools. A Scoping Review (Preprint)
Authors: Busshart Lisa , Petrovic Milica , Amin Rebeka , Hegerl Ulrich
Published: January 2025

BACKGROUND

Digital health interventions based on self-management strategies aim to empower users’ self-reliance by utilizing self-monitoring, self-assessment and sensor-based output. The existing variety of digital devices utilizes a wide range of data sources and sensors to collect and monitor users’ output while little comparative data on parameter reliability and utility is available.

OBJECTIVE

This review aims to address the existing methodological and knowledge gap in understanding the efficient common parameters used among digital health interventions for depression that allow precise monitoring and prediction of the course of depression across different modes of digital intervention delivery.

METHODS

Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews digital databases including PubMed, Embase, Cochrane Library and Web of Science Core Collection were scoped for literature ranging from 2021 to 2024. A five-stage framework by Arksey and O’Malley (2005) was implemented to ensure systematic scoping of the literature. The quality of the retrieved studies was assessed using the Downs and Black Instrument and the Mixed Methods Appraisal Tool.

RESULTS

The overall five interdependent categories were defined including 1) Physical activity and Location, 2) Behavioural patterns, 3) Physiological data, 4) Sleep, and 5) Sociability and Self-reported assessments to best describe common assessment parameters across the literature. Eleven common clinical measures and self-report assessments were distinguished across defined categories as assessment combined with digital phenotyping methodology.

CONCLUSIONS

Synthesis of result sections of the included studies indicated that predicting depressive symptoms by combining clinical assessment and digital phenotyping is a promising approach for further improvement of digital interventions. The overall strongest associations were found in combined approaches using parameters across categories combining sensor data and self-report assessment.
The Effectiveness of a Question-Embedded Movie Clips Learning Program in Nursing Students: A Quasi-Experimental Pretest–Posttest Study (Preprint)
Authors: Choenarom Chanokruthai
Published: January 2025

BACKGROUND

Technological innovations make significant impacts on nursing education. New teaching strategies are constantly emerging, offering students a dynamic and interactive educational experience. The Question-Embedded Movie Clips Learning program used in the current study was developed based on the drill and practice learning principle, aiming to facilitate nursing student’s skills and build their confidence before entering real clinical settings.

OBJECTIVE

To investigate comparative effect between the newly developed Question-Embedded Movie Clips Learning program and the current practice of mind mapping exercises on students’ learning outcomes and study satisfaction.

METHODS

This study adopted a pretest-posttest non-equivalent groups quasi-experimental design. The study sample consisted of 132 third-year nursing students who enrolled in one of two class sections of the psychiatric nursing course in a university in Thailand. By flipping a coin, the first study section (N = 62) was assigned to the intervention and the second section (N = 70) was assigned for the control group. During the 2-hour class sessions, students received identical learning structure and sequence, except for group exercise of either the Question-Embedded Movie Clips Learning program or the mind mapping. The data were collected through the pretest-posttest questionnaire, the perceived satisfaction with the learning experience scale and the open-ended reflective questions.

RESULTS

A statistically significant increase was observed in the learning outcome scores of both the intervention group (t = -30.48, 95% CI -10.59 to -9.28, P < .001) and the control group (t = -27.04, 95% CI -8.19 to -7.07, P < .001). There was, however, a statistically significant difference in the outcome scores between the two groups. Even after controlling for pretest scores, students in the experimental group had a significantly higher adjusted mean score than those in the control group (F = 67.67, P < .001).

CONCLUSIONS

The study has provided empirical evidence that using Question-Embedded Movie Clips Learning program along with traditional instruction in teaching therapeutic relationship and communication significantly improves learning outcomes.

CLINICALTRIAL

not applicable
Real-Time Network Topology Optimization Using Dynamic Machine Learning Adaptation
Authors: Garg Riddhima , Budhiraja Ritika , Gupta Akshita , Sharma Hardik , Thangalazhi Suryagayatri
Published: January 2025

Abstract: The environmental complexities of evolving network infrastructures require adaptively efficient and smart optimization
of topologies in network environments. At present, the changing requirements of various networks within applications with realtime dynamic inputs fail to adapt in such circumstances that involve changes to data traffic, user demands, and environmental
factors. Traditionally, static topologies fail to cope with the same. This paper establishes a new framework called Dynamic
Network Topology Optimization (DNTO), which is powered by advanced machine learning algorithms, to optimize network
configurations autonomously. The proposed framework integrates reinforcement learning to enable dynamic topology
adjustments through learning from evolving traffic patterns to improve adaptability and resilience in network infrastructures. It
optimizes multiple KPIs concerning latency, throughput, and energy efficiency and minimizes intervention and downtime. This
efficacy of the proposed framework is further presented with effectively improved performance and adaptability over the static
topology optimization methods, through experiments run on simulated and actual network scenarios. Scalable and intelligent
solution for evolving networks constitutes this work and lays down an important foundation for real-time autonomous
management of networks in areas of IoT, 5G, and cyber-physical systems.
Uso de tecnologias digitais avançadas para o monitoramento da saúde mental de idosos em tempo real: um estudo sobre IA e aplicativos móveis
Authors: Breviário Álaze Gabriel do , Rosa Denise Oliveira da , Mendes Willians Ribeiro , Dias Sônia Maria , Asensi Felipe Dutra , Martins Islane Cristina
Published: January 2025

Introdução: esta pesquisa explora o impacto das Tecnologias Digitais de Informação e Comunicação (TDICs), como Inteligência Artificial (IA) e Realidade Virtual (RV), no monitoramento e promoção da saúde mental de idosos. Contextualiza-se na crescente importância de tecnologias para o cuidado com a população idosa, considerando o aumento da expectativa de vida e a prevalência de transtornos mentais nessa faixa etária. A problemática está na falta de compreensão sobre a eficácia dessas tecnologias para a saúde mental, especialmente em promover autonomia e bem-estar emocional. Objetivo: compreender e analisar como as TDICs contribuem para a prevenção e a promoção da saúde mental de idoso, em tempo real, facilitando o acompanhamento contínuo e intervenções personalizadas. Metodologia: adotou-se o paradigma neoperspectivista giftedeano e o método hipotético-dedutivo, apoiando-se nas teorias do Envelhecimento Ativo, da Autonomia Idosa e da Adesão Tecnológica. Conduziu-se uma Revisão Bibliográfica e Documental Narrativa nas bases Scopus, PubMed e Web of Science, resultando em 68 estudos analisados. Resultados: os achados indicam que a IA e a RV podem melhorar o bem-estar dos idosos, especialmente com suporte familiar e interfaces amigáveis, embora barreiras econômicas e psicossociais ainda limitem o acesso e a aceitação das tecnologias. As principais limitações incluem a dependência de dados secundários e a falta de estudos longitudinais. Conclusões: a pesquisa contribui para a compreensão teórica e prática das TDICs na geriatria, com valor agregado para a inclusão digital, promoção de políticas públicas e bem-estar na terceira idade.
ESTUDIO DE CASO: INNOVANDO EL APRENDIZAJE DEL IDIOMA INGLÉS EN UNA CARRERA DE SALUD EN CHILE.
Authors: Ibarra Pérez Andrés , Calvo-Irrazabal Manuel
Published: January 2025

Objetivo: el objetivo de este estudio fue analizar el impacto de la aplicación de la metodología Aprendizaje Basado en Proyectos (ABPr) como una forma de innovación en la enseñanza de los contenidos programáticos de la asignatura de inglés en estudiantes de Tecnología Médica (TM).
Material y método: para desarrollar este estudio se diseñaron variados recursos educativos entre TM y Educación Parvularia (EPA), en los que se aplicó ABPr. Asimismo, a través de un análisis de una encuesta de percepción estudiantil, se identificaron otros productos esperados de esta aplicación.
Resultados: la evaluación objetiva de los trabajos desarrollados evidenció un impacto positivo en el proceso de aprendizaje de los contenidos programáticos de la asignatura de inglés I en el estudiantado de TM. Además, se detectaron otros efectos de la aplicación del ABPr tales como creatividad, trabajo cooperativo entre estudiantes de TM, autoeficacia y trabajo colaborativo e interdisciplinar con estudiantes de EPA.
Conclusiones: el análisis de los resultados refleja que la aplicación del ABPr contribuye a la innovación en la enseñanza del inglés en la educación superior y, además, reafirma la utilidad de esta herramienta como un instrumento útil en procesos de innovación curricular.
DIÁSTASIS DE LOS MÚSCULOS RECTOS ABDOMINALES Y LA SEXUALIDAD EN LAS MUJERES EN EL POSPARTO.
Authors: ESTRADA GALDAMES JUSSELIT , T. OCHAR JUDITH , A. SALAS CATALINA , B. GUZMÁN CAMILA , I. RUBILAR FABIOLA , M. COFRÉ DANIELA
Published: January 2025

Introducción: Durante la gestación se separan los músculos rectos del abdomen, denominado diástasis abdominal.
Objetivo: Relacionar la diástasis de rectos abdominales (DRA) junto con el funcionamiento sexual femenino en el posparto.
Material y Método: Estudio correlacional de corte transversal, en una muestra de 99 mujeres en control en la provincia de Arauco. Se diseñó un cuestionario para la recolección de los datos demográficos y obstétricos, se realizó la técnica de palpación de los músculos rectos abdominales de la usuaria. Por último, se aplicó la encuesta IFSF.
Resultados: La medición de la diástasis supraumbilical y umbilical fueron de 1,9 cm y la de nivel infraumbilical de 1,63 cm. Con respecto al funcionamiento sexual destaca el dominio satisfacción con un 5,3 y le sigue lubricación con 4,9. El puntaje del IFSF fue 27,5. Al relacionar la diástasis abdominal con el funcionamiento sexual femenino se encontró una relación estadísticamente significativa entre el dolor y la medición de la diástasis y la satisfacción sexual.
Conclusiones: Durante el posparto, la detección de DRA a través de la palpación es una excelente modalidad de bajo costo que se puede implementar, además de evaluar el funcionamiento sexual durante estos controles permitirá educar precozmente a las usuarias.
Soviet Icons and Semiotic ideologies: What Guides People When They Guide Icons
Authors: Antonov D. I. , Zavialova A. I.
Published: January 2025

The paper focuses on the semiotic ideologies that define the ways of designating old things and the practice of interacting with them in the post‑Soviet countries. Soviet icons, the most common religious artifacts of the Communist era, also passed into the category of “old things” after the collapse of the USSR. Their functions, loci of existence and symbolic status changed when the Soviet state ceased to exist. The assessments and practices of handling icons of the Soviet years are influenced by five semiotic ideologies that the authors identify and which are generally characteristic of modern Russian society: historical, antique, family, modernizing and the ideology of the “dangerous thing”. They all acquire another dimension when complemented by the idea of virtue, typical for the religious field. Each of these attitudes has developed in its own socio‑cultural environment and under the influence of various historical processes. In modern society, they are in constant interaction, sometimes entering into confrontation: they compete in the minds of “moderaters” (icon owners, prists, etc.), “shine through” each other, change depending on the communicative situation. The one that will prevail over the others will ultimately determine whether the moderator chooses the practice of preserving Soviet icons or will dispose of them. In the final part of the article, the authors analyze the influence that researchers (historians, anthropologists) can have on “moderators”, communicating with them during expeditions and voluntarily or involuntarily provoking them to changing/switching between semiotic ideolgies.
The Processional Cross and the Transient Icon: Replicas of Liturgical Practices in the Catholic-Orthodox Borderland and Their Dynamics in Late Soviet and Post-Soviet Times
Authors: Moroz A. B.
Published: January 2025

The article describes two religious ritual practices widespread in the Catholic‑ Orthodox borderland and formed under the influence of (para)liturgical practices as a kind of “replica” of them. The use by the rural community of a cross similar to the cross carried during processions and funerals probably began during the Soviet period, when church funeral processions were banned and then the churches were closed. These crosses, made by locals, are kept in the homes of those revered as religious leaders and belong to the entire village community. When someone dies in the village, this cross is taken to the house of the deceased and then it is carried with the coffin to the cemetery. Another rite called the Rite of the Candle is the veneration of an icon or a special candle belonging to whole village community. On a certain Christian holiday, the “Candle” is carried from the house where it has been located during the year to another where it will be located through the next year. The rite was apparently formed at the time of the spread of the Union of Brest and on the territory where it was in force. In Soviet times, this rite, which retained its main features, has been considered by local residents as a substitute of church services. The rite reflects liturgical and paraliturgical practices that are widespread: the proskomidia, the consecration of bread, wine and oil, the collection and use of material evidence of piety, and the passing under the shrine. The very moment of carrying the “Candle” from house to house resembles a procession. At the same time, in the attitude to the place of the Candle’s stay we can see the construction of a sacred space replacing inaccessible temples: as long as the “Candle” is in the house, this house is open to any visitor at any time. Any person, even those who do not know the owners, can come there, pray, light a candle, ask for help. Both the cross and the icon or candle are regarded as common property, not belonging to anyone in particular, but representing an undoubted sacred object with which the rural community associates itself. At present, rituals are being reborn and adapted to new conditions.
The Icon as a “Nest”. The History of Complex Shrines: From the Church Icons to the Soviet Icons
Authors: Antonov D. I.
Published: January 2025

The article examines the peculiarities of the creation and existence of icons in the Middle Ages and Modern Times. The author shows that revered prayer images, both in the church and at home, most often functioned as part of integrated objects that consisted of metal vestments, fabrics, votive gifts, cases and other elements. Icons were built as symbiotic and later as hybrid objects, all parts of which were perceived as an “expanded body” of the shrine. The changes came at the beginning of the 20th century, when, as a result of scientific restoration, many ancient icons were disintegrated, cleared and presented at exhibitions. Soon after, the confiscation of church valuables, organized by the Bolsheviks, led to the destruction of almost all integrated icons in the country. The museumification of the cleared icons, and their replication in print media has reconfigured the optics of both specialists and the mass audience. Icons began to be understood, perceived and described as “pure images”, works of pictorial art. This optics became common to Soviet citizens who visited the museum and saw publications on Russian iconography, as well as to foreigners who are familiar with the phenomenon primarily through albums and books. However, the author of the article shows that this “museum” logic had clear social boundaries. The perception of icons has not changed among residents of the Soviet province. The craftsmen who worked in the villages made Soviet icons as integrated objects. They called the prayer image a picture and considered it only one of the elements of the icon. Their creations turned out to be the direct heirs of integrated icons of the Middle Ages and Modern Times. Both the craftsmen and the owners of Soviet icons shared the same optics and the same logic of interaction with prayer images that have was typical for Christian culture for centuries.
Impact of Newly Planned Detectors on the Standard Model Analysis of pp → W+Z at the HL-LHC
Authors: ALYASIRI Muhanad , Gaber FAISEL
Published: January 2025

The High-Luminosity Large Hadron Collider (HL-LHC) promises unprecedented sensitivityto Standard Model (SM) processes and new physics scenarios. This study focuseson the production of pp → W+Z, with subsequent decays W+ → ℓ+ νe and Z → ℓ+ ℓ−.We explore the impact of planned detector upgrades on precision measurements andsensitivity to Beyond Standard Model (BSM) phenomena. Using insights from simulations,this paper highlights the role of advanced detectors in improving reconstruction,reducing uncertainties, and extending the discovery reach in vector boson interactions.
In Silico Study of Bioactive Compounds of Putat Leaf Extract (Planchonia valida) as Anti-Cancer Against the VEGFR2 Receptor
Authors: Bela Anisa , Dewi Tribuana Tungga , Prabawa Satria , Khatib Alfi , Yusnaidar Yusnaidar , Latief Madyawati , Tarigan Indra Lasmana
Published: January 2025

Cancer is the process of forming new tissue that is abnormal and malignant. Efforts to discover anti-cancer drug compounds continue to be made to minimize the toxic effects of chemotherapy, so it is necessary to look for other alternatives to treat cancer. This research aims to determine the anti-cancer activity of putat plant bioactive compounds through identification of receptor targets and interaction studies using the molecular docking method against the VEGFR2 (Vascular endothelial growth factor receptor-2) receptor.
The results showed that in the test of eight putat plant bioactive compounds the best results were obtained for the compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with a binding free energy value of -9.86 kcal-mol-1 with an inhibition constant value of 1.47 Micromolar. The best docking result has an inhibition constant value that is higher than the native ligand and has a binding free energy that is almost close to the binding free energy of the native ligand with an inhibition constant value of 42.38 Micromolar and a binding free energy value of 10.06 kcal-mol-1. Therefore, the results of the docking of the bioactive compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with the VEGFR-2 receptor are considered capable of being an alternative as a candidate for anti-cancer drugs.
The impact of gold mining on the small rivers of the Zeisky district in 2023
Authors:   Far Eastern State Agrarian University, Litvintseva Natalia S. , Pakusina Antonina P. ,   Far Eastern State Agrarian University
Published: January 2025

In 2023, the hydrochemical parameters of the small Makcha, Pikan
and Umlekan rivers were monitored, where gold mining was carried out by diligent
artels. Small rivers are characterized by high turbidity. High values of lead, copper
and zinc were found in the summer. It is necessary to oblige gold mining enterprises
to carry out reclamation after the end of production.
John I Tzimiskes and Basil II: Two approaches to the Byzantine policy in the Balkans
Authors: Cvetkovic Milos
Published: January 2025

The text analyzes different methods and principles implemented by emperors
John I Tzimiskes and Basil II during the pacification and integration of the
Balkans into the Byzantine political and legal framework. Modern historians
agree that Basil?s approach proved more effective in dismantling the
Bulgarian state and reoccupying the Balkans, but the contemporary
intellectual elite seems to have had a different view of the strategies
those two emperors pursued in the Balkans. Hence, the paper also assesses
their success through the lens of the contemporaneous Byzantine political
mindset.
An illustration of the heavenly ladder of John Climacus in Psellos’ funeral eulogy dedicated to Nikolaos of the monastery of the beautiful source
Authors: Moniou Dimitra
Published: January 2025

The present study is based on a passage in Michael Psellos? funeral eulogy
dedicated to Nikolaos, the founder and abbot of the monastery of the
Beautiful Source (??? ?????? ?????) on Mount Olympus in Bithynia. The writer
describes one of the monastery?s illustrations depicting the Heavenly Ladder
of John Climacus. The monks of this monastery were uneducated, and this was
likely the reason Nikolaos chose to depict ascetics? figures and scenes in
the entry of the church as personifications of basic virtues. Psellos?
description is significant not only because it is a precious testimony of a
monastery that no longer exists but also because it is an early sample of
Byzantine art about the Climax, given that the principal Climax cycles come
from the 11th c.
Screening for Metabolic Dysfunction–Associated Steatotic Liver Disease–Related Advanced Fibrosis in Diabetology: A Prospective Multicenter Study
Authors: Caussy Cyrielle , Vergès Bruno , Leleu Damien , Duvillard Laurence , Subtil Fabien , Abichou-Klich Amna , Hervieu Valérie , Milot Laurent , Ségrestin Bérénice , Bin Sylvie , Rouland Alexia , Delaunay Dominique , Morcel Pierre , Hadjadj Samy , Primot Claire , Petit Jean-Michel , Charrière Sybil , Moulin Philippe , Levrero Massimo , Cariou Bertrand , Disse Emmanuel
Published: January 2025

OBJECTIVE

Screening for advanced fibrosis (AF) resulting from metabolic dysfunction–associated steatotic liver disease (MASLD) is recommended in diabetology. This study aimed to compare the performance of noninvasive tests (NITs) with that of two-step algorithms for detecting patients at high risk of AF requiring referral to hepatologists.

RESEARCH DESIGN AND METHODS

We conducted a planned interim analysis of a prospective multicenter study including participants with type 2 diabetes and/or obesity and MASLD with comprehensive liver assessment comprising blood-based NITs, vibration-controlled transient elastography (VCTE), and two-dimensional shear-wave elastography (2D-SWE). AF risk stratification was determined by a composite criterion of liver biopsy, magnetic resonance elastography, or VCTE ≥12 kPa depending on availability.

RESULTS

Of 654 patients (87% with type 2 diabetes, 56% male, 74% with obesity), 17.6% had an intermediate/high risk of AF, and 9.3% had a high risk of AF. The area under the empirical receiver operating characteristic curves of NITs for detection of high risk of AF were as follows: Fibrosis-4 (FIB-4) score, 0.78 (95% CI 0.72–0.84); FibroMeter, 0.74 (0.66–0.83); Fibrotest, 0.78 (0.72–0.85); Enhanced Liver Fibrosis (ELF) test, 0.82 (0.76–0.87); and SWE, 0.84 (0.78–0.89). Algorithms with FIB-4 score/VCTE showed good diagnostic performance for referral of patients at intermediate/high risk of AF to specialized care in hepatology. An alternative FIB-4 score/ELF test strategy showed a high negative predictive value (NPV; 88–89%) and a lower positive predictive value (PPV; 39–46%) at a threshold of 9.8. The FIB-4 score/2D-SWE strategy had an NPV of 91% and a PPV of 58–62%. The age-adapted FIB-4 score threshold resulted in lower NPVs and PPVs in all algorithms.

CONCLUSIONS

The FIB-4 score/VCTE algorithm showed excellent diagnostic performance, demonstrating its applicability for routine screening in diabetology. The ELF test using an adapted low threshold at 9.8 may be used as an alternative to VCTE.
Impacto de las relaciones sociales en la calidad de vida de los cuidadores informales de personas con enfermedad de Alzheimer: una revisión sistemática
Authors:   Universitario en Gerontología y Atención Centrada en la Persona, Cañar, Ecuador., Padilla Pino Katy Elizabeth
Published: January 2025

El estudio buscó describir las relaciones sociales y su impacto en la calidad de vida de los cuidadores informales de personas con enfermedad de Alzheimer. Se realizó una revisión sistemática de la literatura en Medline (Pubmed), LILACS, Scielo, Cochrane Library y Web of Science, con investigaciones cualitativas y cuantitativas que analizaron la afectación de las relaciones sociales en los cuidadores informales de adultos o ancianos con enfermedad de Alzheimer. Se encontraron 516 referencias, de los cuales 10 fueron finalmente seleccionadas. La mitad de los estudios concluyeron que las relaciones sociales de los cuidadores informales se vieron afectadas. La carga de los cuidadores informales puede perjudicar sus relaciones sociales, por lo cual, se deben considerar intervenciones gerontológicas desde la prevención primaria hasta su manejo oportuno y eficaz.