bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPARATIVE ANALYSIS OF THE REINDUSTRIALIZATION OF NATIONAL ECONOMIESIN THE CONTEXT OF THE RESTORATION AND DEVELOPMENT OF THEIR INDUSTRIAL POTENTIAL
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Grazhevska Nadiya , Osetskyi Valeriy ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Khodzhaian Alina ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Kulish Viktoriia ,   Taras Shevchenko national University of Kyiv
Published: September 2023

The article, the purpose of which is a comparative analysis of the reindustrialization of national economies, analyzes the main approaches to understanding the concept of "reindustrialization", identifies the main features of the economic policy of reindustrialization in the context of the restoration and development of the industrial potential of the countries of the world. The main characteristics of reindustrialization are the restoration of production capacities, orientation towards high-tech production, innovative and technological modernization of production, and the development of collaboration between science and production. Based on the results of a hierarchical cluster analysis of the distribution of countries of the world according to the level of reindustrialization of national economies, five main groups of countries have been formed. The group of leading countries focusing on high-tech industries includes China, Germany, Great Britain, the United States, France, Switzerland, Japan, and others. Ukraine, according to the results of cluster analysis, is included in the block of countries with a low level of reindustrialization of the economy. The share of medium- and high-tech production for this group is almost two times less than that of highly reindustrialized ones. Based on the results of the study, the necessity is substantiated and the main mechanisms for enhancing the reindustrial renewal of the domestic economy are determined. A comparison of the results of economic development in the orientation to the agricultural sector and the application of the reindustrial concept of socio-economic development is carried out. It is shown that with the implementation of the economic policy of reindustrialization, orientation to the high-tech sector, digitalization, and digitalization, Ukraine can achieve economic growth by 5 times by 2045.
FINANCIAL SUSTAINABILITY OF THE AGRICULTURAL SECTOR OF UKRAINE UNDER MARITAL LAW
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Liudmyla Demydenko , Nakonechna Yuliya ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: September 2023

The article focuses on the military aggression's impacts on the financial sustainability of the agricultural sector in Ukraine as well as the priority measures required to ensure the food and economic security of Ukraine under martial law. Ukraine has to solve problems of unprecedented complexity: ensuring food security on the domestic market and selling agricultural products on the world market under the difficult conditions of war. The performance of agricultural enterprises is analyzed as the stability of their functioning is strategically important not only for the domestic economy, but also for the overall world food market. At the same time, the authors emphasize factors and processes which contribute to the higher financial sustainability of agricultural production, as well as those, which inhibit the development of agrarian business in Ukraine. The authors define the financial sustainability of the Ukrainian agricultural sector under martial law as the ability to provide sufficient financial resources for the process of expanded reproduction of agricultural production, considering the range of financial measures and tools (preferential taxation, loans, donor aid) as well as and non-financial ones (military, diplomatic, logistic). The agricultural sector of Ukraine remains one of the key sectors of both domestic and global economies, as it carries out a highly important mission of providing food to the citizens of our state, as well as to about 100 million citizens outside the country, and its role will be growing further. Based on this issue, the authors consider Ukraine's victory as a vital task not only for the citizens of Ukraine but also for all developed and developing countries. Key features of the state policy aimed at supporting exporters of agricultural products to ensure the financial sustainability of the agricultural sector of Ukraine are defined.
Extended orthogonal feedback precoding for spatial multiplexing systems
Authors:   Moscow Technical University of Communications and Informatics, Bakulin Mikhail G. , Kreyndelin Vitaly B. ,   Moscow Technical University of Communications and Informatics, Reznev Andrey A. ,   Scientific-Technical Center "Atlas"
Published: September 2023

Various methods of generating of space-time codes and algebraic structures for increasing noise immunity of MIMO communication systems with a large number of transmitting and receiving antennas are considered. The possibility of generation of an orthogonal precoding matrix in MIMO systems depending on changing reception conditions in a radio channel using feedback from a transmitter to a receiver is shown. It is obtained that to transmit such a precoding matrix in MIMO systems with 4×4, 8×8, 16×16 antenna configurations, feedback is required with the ability to transmit only 2 bits on the reverse link at an energy gain of 1.5 dB ... 2.5 dB compared to an open loop system. The precoding matrices obtained in the article and their formation algorithms can be used in the development of new MIMO mobile communication systems.
70 years of Kotelnikov Institute of Radioengineering and Electronics of RAS
Authors:   Kotelnikov Institute of Radioengineering and Electronics of RAS, Grachev Vladimir I.
Published: September 2023

Information is presented on the organization and activities of Kotelnikov Institute of Radioengineering and Electronics of Russian Academy of Sciences. Its scientific directions are covered, the main results of fundamental scientific, exploratory and applied research are noted, as well as the training of highly qualified personnel (candidates and doctors of science) and the presence of close international scientific ties.
Method for selecting the damping characteristics of the pneumohydraulic suspension system of a wheeled vehicle
Authors: Sarach Evgeny B. , Krokhin Maxim E. , Lychagov Alexander A. , Smirnov Ilya A. , Kositsyn Boris B.
Published: September 2023

BACKGROUND: In the process of developing suspension systems for modern high-speed wheeled and tracked vehicles, having the selected optimal elastic characteristic curve of the suspension system, its unsatisfactory damping characteristic curve can have a significant negative impact on the overall operation of the suspension unit. Therefore, the search for a method for obtaining the optimal damping characteristic curve is a relevant task.
AIMS: Description the method for selecting the damping characteristic curve of a single-level pneumohydraulic spring for a wheeled vehicle considering the motion along tracks with a harmonic profile and a rough cobblestone road.
METHODS: The damping characteristic curve of the spring is selected using simulation mathematical modeling in the MATLAB/Simulink software, which makes it possible to take into account the nonlinearity of the suspension characteristics. In the process of building the characteristic curve, the limit values of the forces at the front wheels tires are fixed for the sections of the characteristic curve that operate with the valves of the pneumohydraulic spring turned off. Accelerations at the driver's seat and the pressure in the spring chamber are fixed for the sections of the characteristic curve that operate with the valves are turned on.
RESULTS: The results of the selection of an optimized damping characteristic curve showed an improved contact of the wheels with the surface and an increase in the stability of the vehicle, a decrease in vibration accelerations at low disturbance frequencies.
CONCLUSIONS: The practical value of the study lies in the possibility of using this method to develop suspension systems for new wheeled and tracked vehicles.
Relationship between obsessional dissociation and family adjustment and anxiety sensitivity in individuals with obsessive-compulsive disorder
Authors: POLAT Hatice , KARTAL Fatma , UĞUR Kerim
Published: September 2023

Purpose: The aim of this study was to determine the relationship between obsessional dissociation, family accommodation, and anxiety sensitivity in individuals with obsessive-compulsive disorder (OCD).

Materials and Methods: The participants of this descriptive and relationship-seeking study were 62 individuals with OCD and 43 healthy controls. We collected data using a sociodemographic data form, the Yale-Brown Obsessive Compulsive Scale (YBOCS), the Family Accommodation Scale-Patient Version (FAS-PV), the Anxiety Sensitivity Index-3 (ASI-3), and the Van Obsessional Dissociation Questionnaire (VOD-Q).

Results: Both the ASI-3 and VOD-Q subscale and global scores of the patients participating in the study were higher than those of the healthy controls, and there was a statistically significant difference between the two groups. Sixty-two percent of the total score of VOD-Q was explained by the ASI-3 total and subscale scores, 16% by the YBOCS total and subscale scores, and 11% by the FAS-PV total and subscale scores (F:38.622; F:6.797; and F:2.941, respectively).

Conclusion: In our study, individuals diagnosed with OCD had higher levels of obsessional dissociation than healthy individuals and anxiety sensitivity, obsessive-compulsive symptoms, and family accommodation are effective in the development of obsessional dissociation in individuals diagnosed with OCD.
Concurrent medulloblastoma and Chiari Type-I deformity in a pediatric case
Authors: SÜRÜCÜ KARA İlknur , ÇAKIR Tayfun
Published: September 2023

Concurrence of medulloblastoma and Chiari deformity (type-1) in a pediatric patient is extremely rarely seen. 10 years old girl. She had first complained of nausea, abdominal pain, and vomiting. She had a mild headache for three days. Computed tomography was taken. There were sequelae related to her previous illness and noticed the appearance of the left cerebellar tonsils down to the foramen magnum level and mild prominence in the third ventricle. Cranial imaging was performed with magnetic resonance imaging. There was a lesion as a solid mass, about 60 mm sized in the level right cerebellar, a cerebellar tonsil hernia (11 mm), and ventricular dilatation in magnetic resonance imaging. Histologically, the lesion was a classic type of medulloblastoma. The coexistence of two diseases may occur in the same patient. Magnetic resonance imaging, which indicates the craniovertebral junction can be used singly.Because MRG is the first method to be selected for diagnosis.
EZH2 expression in the skin of developing human fetuses and adults: a comparative study
Authors: ZORLU Özge , KARABAĞ Sevil , ERDOGAN Kivilcim , KUŞSEVER Evin , ÖZER ASLAN İlke
Published: September 2023

Purpose: In animals, the appropriate levels of Enhancer of zeste homolog 2 (EZH2), a well-established epigenetic regulator, are essential for the embryonic development of skin and appendages. We aimed to explore the EZH2 expression patterns in the skin of human fetuses and compare them with adults.

Materials and Methods: We performed EZH2 immunohistochemical staining in skin samples from the scalp region of 67 fetuses and from the farthest surgical margin of the lip wedge resection, where no lesions were found, of 23 adults. EZH2 scores were evaluated according to the literature.

Results: Epidermal (r = − 0.528), dermal (rs = − 0.509), and hair follicle (r = − 0.576) EZH2 scores were inversely correlated with gestational age. Epidermal and hair follicle EZH2 scores were significantly higher in adults compared to fetuses. There were significant and positive correlations between epidermal, dermal, and hair follicle EZH2 scores among fetuses and adults.

Conclusion: Lower levels of EZH2 may be necessary for final cutaneous differentiation and maturation before birth. Our findings may have a therapeutic impact on cutaneous disorders with differentiation defects, chronic wounds, and alopecias.
Evaluation of drug-drug interactions in critically ill pediatric patients
Authors: SURMELİOGLU Nursel , SOYSAL Hatice Yağmur , TÜRKER İkbal , EKİNCİ Faruk , OZGUR HOROZ Ozden , YILDIZDAŞ Dinçer
Published: September 2023

Purpose: The aim of this study was to determine the drug-drug interactions that are frequently encountered in critically ill patients and the factors that predict these interactions.

Materials and Methods: All patients who were admitted to the pediatric intensive care unit (13 bed) of a university hospital and used more than one drug in their treatment were included in this prospective and cross-sectional study. Patients' demographics, laboratory findings, and medications included in their treatment were evaluated daily by a clinical pharmacist. The UpToDate® database was used to detect potential drug interactions.

Results: During the study, 797 potential drug-drug interactions were detected in 55 (83.33%) of 66 patients followed. All these interactions were evaluated by the clinical pharmacist and 114 recommendations were made to the physicians following the treatment regarding these potential interactions. Eighty-five (74.56%) of these recommendations were accepted by physicians. Within the scope of the study, each patient was followed up for a median of 9 (2-63) days, and the median value of potential drug interactions detected during this period was calculated as 7 (1-89).

Conclusion: The existence of pDDIs was significantly associated with the number of prescribed medications. Exposure to pDDIs is frequent in critically ill pediatric patients and related to the number of medications. Daily and close cooperation between clinicians and clinical pharmacists is recommended to prevent harmful outcomes of DDIs. In order to minimize this risk, it is recommended to avoid polypharmacy as much as possible and to offer alternatives to inducer and inhibitor drugs in treatment.
Analyzing the Temporal Variation in Macroseismic Intensity Rating Values and Predicting Macroseismic Intensity on the Tibetan Plateau
Authors: Liu Zhenbiao , Yu Yanxiang , Xiao Liang
Published: September 2023

China has relatively rich macroseismic isoseismal maps, which play an important role in seismic hazard analysis and the development of reliable earthquake loss models. The macroseismic intensity is assessed based on the Chinese Seismic Intensity Scale, which is constantly being revised as research progresses and the seismic defense capability is enhanced. To investigate whether intensity rating values show consistency across time in statistical significance, this study collected 543 isoseismal lines for 216 earthquakes on the Tibetan Plateau from 1960 to 2020. Taking intensity prediction equations (IPEs) as a reference, statistical tests of the residuals indicate that there is temporal variation in intensity rating values, which is inconsistent with the default assumption that intensity rating values are consistent for different time periods when developing IPEs. Therefore, we analyze the characteristics of intensity rating values by statistical tests and investigate the mechanism by which the temporal variation in intensity rating values affects IPEs by residual decomposition. The results show that despite the temporal variation in intensity rating values, they can still be used to develop IPEs, and that temporal variability can be reduced by adjustment. Finally, we obtain the regression process of IPEs based on the partially nonergodic assumption considering the temporal variation in intensity rating values, and perform a case study, using the Tibetan Plateau as an example.
Time-Varying Moment-Tensor Analysis with Application to Buried Chemical Explosions
Authors: Kintner Jonas A. , Michael Cleveland Kenneth , Eric Pippin James , Thomas Modrak Ryan , Delbridge Brent
Published: September 2023

The Source Physics Experiment (SPE) Phase I consisted of a series of over-buried, horizontally colocated chemical explosions at the Nevada National Security Site. Seismic waveforms from these explosions recorded at near-source accelerometers, local geophone arrays, and regional seismic stations provided a rich suite of observations suitable for resolving fine source details. To investigate the time-varying source history of the explosions, we used the frequency-domain moment-tensor inversion method described in Yang et al. (2018) with added regularization and reconstruction to suppress the nonuniqueness evident in unconstrained inversion results. The inverted moment-rate spectra are accurate within the response band of the local geophones and, in all cases, display predominately isotropic characteristics. For SPE-4Prime, SPE-5, and SPE-6, we resolve predominately isotropic moment release followed by double couple and compensated linear vector dipole (CLVD) release later in the time-varying source history. We interpret these results both in terms of absolute depth and scaled depth of burial. The apparent non-isotropic release from SPE-4Prime and SPE-5 may simply reflect increased resolving power related to improved Earth model accuracy at greater absolute depths, whereas the non-isotropic release from SPE-6 likely reflects the larger damage associated with an event at a shallower scaled depth. These results provide insight into the time-varying source characteristics of shallow explosions and motivation to study shear-wave generation by inverting for fracture, spallation, induced slip, and other temporally delayed source processes through time-varying methods.
Farm Crime and Security: Evaluating Smart Tag Technology for Preventing, Tracking and Recovering Stolen Livestock
Authors: Mulrooney Kyle , Harkness Alistair
Published: September 2023

This research study evaluates the efficacy of Ceres Tag, a livestock information platform that utilises a unique smart tag, in improving farm security by preventing, interrupting, and reducing livestock theft – a prevalent issue among farmers and landholders in countries like Australia. The Ceres Tag is equipped with an accelerometer and global navigation satellite system (GNSS) technology to collect data on animal health, welfare, movement, and traceability. It was hypothesised that the Ceres Tag could combat livestock theft by enabling interventions at three key stages: rapid prevention, tracking of stolen livestock, and recovery of stolen livestock. To assess this, a mock theft of livestock was staged, accompanied by a coordinated law enforcement response. Key findings include: (1) the Ceres Tag issued a ‘high activity alert’ to farmers, indicating significant livestock agitation, within 12 minutes of the mock theft initiation; (2) utilising the data, the New South Wales (NSW) Police were able to track and interrupt the livestock theft within 25 minutes; (3) the data enabled the NSW Police to repeatedly track and interrupt the theft on three separate occasions over a 110 kilometre distance and 90-minute period; and (4) following the thieves' arrival at their destination, the NSW Police, aided by the data, recovered the stolen livestock within 20 minutes. The Ceres Tag system increases the risk of criminal behaviour in often riskless rural settings, effectively ‘hardening’ livestock as targets through technological innovation. Furthermore, the platform provides farmers with tangible evidence of a crime, substantially expediting the crime reporting process. This timely reporting, coupled with the data provided by Ceres Tag, positions police for rapid and effective intervention, thereby enhancing their capacity to investigate and resolve incidents of livestock theft. Overall, the results suggest that the Ceres Tag offers a promising technological tool for farmers and law enforcement officers alike, aimed at fortifying farm security and minimizing livestock theft.
Girişimcilikte Dijitalleşme: Kadın Girişimciler Üzerinde Nitel Bir Araştırma
Authors: TURHAN Melike
Published: September 2023

Ekonomik büyüme ve kalkınmanın temel kaynağı olarak görülen girişimcilik faaliyetleri, günümüz teknolojik gelişmeler ışığında hızla değişime ayak uydurma çabası içerisindedir. Ülkelerin girişimcilik ekosisteminde girişimci firma sayılarının arttırılmasında, kadın girişimci rolünün de etkisi gerek araştırmacılar gerekse politika yapıcıları tarafından vurgulanmaktadır. Bu çalışmanın amacını, kadın girişimcilerin girişimcilikte dijitalleşmeyle ilgili bakış açılarını ve dijitalleşmeyi nasıl uygulamaya koyduklarının belirlenmesi oluşturmaktadır. Araştırma nitel araştırma yöntemlerinden fenomenolojik araştırma deseni kullanılarak yürütülmüştür. Araştırma verileri, Amasya ilinde faaliyet gösteren 18 kadın girişimciler ile yarı yapılandırılmış görüşme formu aracılığıyla yüz yüze görüşülerek elde edilmiştir. Verilerin analizinde nitel araştırmalarda kullanılan Maxqda 2022 nitel analiz programı kullanılmıştır. Analiz sonuçlarında “Girişimcilikte Dijitalleşme” ana temasında; “Demografik Özellikler”, “Firma Yapısı”, “Girişimcilik Algısı”, “Kadın Girişimci Olmak” ve “Dijitalleşme Algısı” alt temalar elde edilerek; alt temalar ve kodlamalar arasındaki örüntü katılımcı alıntılarıyla incelenmiştir.
Analysis of the Effects of Magnetic Field on the Haemogram Profile and Protein Content of Eri Silkworm, Philosamia ricini
Authors: Kalita Shibani , Das Bidisha Rani , Bardoloi Sunayan , Sarmah Smritimala , Saharia Sanghamitra , Ojah Anjumani
Published: September 2023

The geomagnetic field is a naturally occurring physical force that operates to sustain life on earth. However, recent advances in technology, rapid urbanization and electromagnetic pollution have led to interferences in strength of the magnetic field, which has resulted in various health hazards in several life forms. This study was carried out to understand the effect of magnetic fields that are greater than the strength of the natural geomagnetic field in Philosamia ricini, commonly known as Eri silkworm. Qualitative and quantitative analysis of the haemogram profile as well as the total protein content, were considered for analysis. The 5th instar silkworm larvae were exposed to two magnetic fields of different strengths, namely 0.4493G and 0.8345G, and changes were recorded and compared with a control group. The results revealed decrease in the number of haemocytes and disruption of haemocytes that increased with increase in strength of magnetic field along. The total protein content of haemolymph also underwent changes with changes in the strength of the magnetic field. Such studies and future in-depth analysis of different biological parameters in organisms due to the changing geomagnetic field might be beneficial in understanding and maneuvering the effects of magnetic field on organisms.
Characterization and Preclinical Toxicity Assessment of Intranasal Administration of Standardized Extract of Centella asiatica (L.) Urban Leaves (INDCA-NS) in Laboratory Rats
Authors: Thakurdesai Prasad , Nimse Savita , Deshpande Pallavi
Published: September 2023

The objective of the present work was to characterize and assess the intranasal toxicity of a solution of total triterpenoids - based standardized extract of Centella asiatica (L.) Urban leaves (INDCA-NS). The acute and 28-day repeated-dose toxicity of intranasal administrated INDCA-NS in Wistar rats was evaluated. For the acute intranasal toxicity study, a single dose of 100 μg/rat/day was administered to five male and female rats and observed for mortality and signs of toxicity for 14 days. In the subacute toxicity study, the INDCA-NS (10, 30, and 100 μg/rat/day) were intranasally administered to a separate group of five male and female rats for 28 days, followed by a 14-day reversal period for behavioral, biochemical, and histological parameters. The effect of subacute administration of INDCA-NS on the ability to smell in rats was evaluated by a buried food test. Treatment with INDCA-NS did not result in mortality or treatment-related adverse signs during single or 28-day repeated-dose administration. In addition, intranasal INDCA-NS did not affect the sense of smell, as observed in the buried food test. Intranasal NDCA-NS was found safe in rats with a Maximum Tolerated Dose (MTD) of more than 100 μg/rat/day and No-Observed Adverse Effect Level (NOAEL) of more than 100 μg/rat/day in male and female rats during acute and subacute intranasal toxicity study respectively.
Cadmium-Induced Perturbation of Spleen Redox Status: Therapeutic Role of Pumpkin Seed Protein Isolate
Authors: Singh Siddhartha , Banerjee Oly , Saha Ishita , Kundu Sudipta , Syamal Alak Kumar , Maji Bithin Kumar , Mukherjee Sandip
Published: September 2023

One of the major threats to humanity is from the exposure of heavy metals irrespective of its source. Cadmium is one of such heavy metals to which humans are exposed in their daily lives via food or environment. Regardless of this, there is no established or efficient way of recycling Cadmium. On the other hand, Pumpkin seeds have innumerable health aiding properties. The present study aims to understand the antioxidative and anti-inflammatory properties of Pumpkin Seeds Protein Isolate (PSPI) against Cadmium mediated oxidative stress in spleen. Twenty male albino rats were divided into four groups; Control, Cadmium treated, Cadmium treated and PSPI 1 supplemented, Cadmium treated and PSPI 2 supplemented. After completion of treatment period (21 days), oxidative stress parameters, ROS generation levels and proinflammatory cytokines were measured along with histopathological evaluations. PSPI supplementation was observed to have significant free radical scavenging activities as evidenced by decreased lipid peroxidation and nitric oxide generation simultaneously with increased glutathione level, activities of superoxide dismutase and catalase. Cadmium also caused an elevation in tumor necrosis factor and interleukin-6 as well as ROS generation levels which were substantially reduced upon supplementation with PSPI. Furthermore, cadmium-induced micro architectural changes in the spleen were also countered upon PSPI supplementation. In summary, both lower and higher doses of PSPI supplementation curtail the cadmium induced oxidative stress, ROS levels, proinflammatory cytokines and damage in the splenic tissue. The Results of this study necessitates further mechanistic study to establish key role of PSPI in amelioration of cadmium toxicity.
Reverse Docking Approach Reveals the Negative Effect of Caffeine Toxicity on Glutamate GluR2 Receptor
Authors: Ansari Hasan , Garg Prekshi , Rastogi Radhika , Sharma Rekha , Srivastava Prachi
Published: September 2023

In the past decade, the consumption of caffeine has increased exponentially throughout the world. Caffeine is now not only limits to coffee but is present in several desserts and other beverages as well. Caffeine is a psychostimulant that helps in improving your performance but its excessive consumption can also affect the cognitive functions of the Central Nervous System (CNS) negatively. The present research is an attempt to understand the mechanism of caffeine action in blocking central nervous system receptors thereby affecting brain function adversely. The reverse docking approach of computational biology has been implied to visualize the interaction of several neurotransmitter receptors with caffeine. Reverse molecular docking is an approach for determining the effect of a ligand on a range of receptors. The binding energy of the receptors with caffeine is considered for determining the best receptor-ligand complex. A list of 7 different neurotransmitters was identified through a literature study and taken into consideration in the current research. The molecular interaction of the human neuro-receptors was seen with caffeine using AutoDock4.0 to study the impact of caffeine on several biological processes of the human brain. The molecular docking approach identifies glutamate gluR2 receptor to be adversely affected by caffeine toxicity thereby affecting the neurotransmission process in the human nervous system.
Development and Application of a Validated HPLC Method for the Determination of Alpelisib and its Process-Related Impurities in Pure Drug and Pharmaceutical Formulations
Authors: Harish Jammu , Kumar Bodasingi Sai , Babu Uppu Naga , Rao Gattupalli Subhakara , Anna Venkateswara Rao
Published: September 2023

Impurity analysis plays a significant role in the manufacture of a safe pharmaceutical product that ensures the safety of consumers. Keeping this in consideration, the present study was intended to develop a simple and sensitive HPLC method for the resolution and quantification of 4 process-related impurities namely impurities 1, 2, 3 and 4 in alpelisib pure drug and formulations. The method consumes greener solvents as a mobile phase that resolves the analytes on ProntoSIL ODS-C18 (250×4.6 mm; 5 μ id) column at room temperature as stationary phase, ethanol and 0.1% aqueous acetic acid in 65:35 (V/V) at pH 4.5 as mobile phase at 0.8 mL/min flow rate, UV detection at 246 nm. The method can detect the analytes at retention times of 7.05, 4.52, 6.09, 2.88 and 8.14 min respectively for alpelisib, impurity 1, 2, 3 and 4. The analysis was completed with a run time of 15 min that consume less solvent and the same analysis time. The linearity of the proposed method was perceived in the range of 12.5 to 100 μg/mL for alpelisib and 0.0125 to 0.10 μg/mL for impurities. The method can effectively resolve the unknown stress degradation products generated during the stress exposure of alpelisib along with its known impurities in the study. The outcomes of other validation studies were likewise satisfactory and proven adequate for regular analysis of alpelisib and its process-related impurities in bulk drug and pharmaceutical tablet doses.
Impact of Amritikarana Procedure on Safety Aspect of Somanathi Tamra Bhasma
Authors: Dalvi Atul , Nariya Mukesh , Chaudhari Swapnil , Patgiri B. J.
Published: September 2023

Somanathi Tamra Bhasma is a unique method of preparation of Tamra Bhasma. In the classics, it is mentioned that if Tamra Bhasma has been used without Amritikarana in therapeutics, it produces ill effects. Hence it should be recommended after Amritikarana process only. Actual impact of this procedure in the preparation of Somanathi Tamra Bhasma has not evaluated till date. This is the first attempt towards preparing Somanathi Tamra Bhasma with Amritikarana (STBA) and evaluate its safety. Three batches of STBA were prepared as per the classical guidelines. In acute toxicity, STBA was administered at a maximal dose of 2000 mg/kg to overnight fasted rats and observed closely for behavioural changes, signs of toxicity and mortality if any, continuously for the first six hours and thereafter periodically up to 14 days. In the repeated dose 90-days oral toxicity evaluation, the test drug was administered daily at the doses of 67.5, 337.5 and 675 mg/kg along with Pippali Churna and honey as an adjuvant to rats for 90 days in divided dose followed by a 30-day recovery period. Animals were sacrificed on the 91st day and haematological, serum biochemical parameters and histopathology of organs were studied. In acute toxicity, STBA at the dose of 2000 mg/kg did not produce any observable toxic effects or mortality. STBA did not produce any significant changes in haematological, biochemical and histopathological parameters at TED and TED x 5 dose levels but mild fatty and inflammatory changes were observed in liver at TED x 10 dose level. These changes were returned to normal at recovery groups. Based on these observations, it can be concluded that STBA is safe at therapeutic dose levels when used judiciously along with specified adjuvants.
Pengaruh Nanovaksin Berbasis Nanopartikel Hybrid Chitosan Terhadap Sel Darah Ikan Kerapu Cantang Yang Diinfeksi VNN
Authors: Hartawan Gian Suryanatha , Yanuhar Uun , Musa Muhammad , Suryanto Heru , Mahasri Gunanti , Supii Apri , Caesar Nico Rahman
Published: September 2023

Cantang grouper (Epinephelus sp.) is a fish with a high economic value and has been widely cultivated. VNN disase, caused by Betanodavirus infection, can lead to mass mortality of cantang grouper. Precautions considered effective in preventing Viral nervous necrosis (VNN) disease include vaccination. This study aimed to determine the effect of administering recombinant Chlorella vulgaris protein nanovaccine based on chitosan hybrid nanoparticles in increasing the immune response of cantang grouper infected with VNN. The study consisted of five treatments: K+ (cantang grouper infected with VNN), K- (healthy cantang grouper), T1 (healthy cantang grouper given 33 µl of nanovaccine and then challenged with VNN), T2 (healthy cantang grouper given 66 µl of nanovaccine and then tested with a VNN challenge), and T3 (healthy cantang grouper given 112 µl of nanovaccine and then tested with a VNN challenge). The parameters observed were haematology, nanovaccine Relative percent survival (RPS), and Survival rate (SR) levels. The study results showed that administering the nanovaccine increased the immune response of the fish, as indicated by an increase in haematology response, RPS, and SR in cantang grouper compared to the treatment without nanovaccine administration. The best dose of nanovaccine in this study is 33 µl.   Keywords: fish disease, nanovaccines, virus, C. vulgaris, grouper
Career Counseling in the Metaverse and the Islamic Perspective: Can it Solve Career Problems for Future Youth?
Authors: Mawarni Anisa , Faızal Faizal , . Abdul Suyukur , Suherman Uman , Supriatna Mamat , Budiamin Amin
Published: September 2023

The problems that teenagers experience are more complex with rapid changes in the current digital era. This is a main constraint as teenagers in this study undergo education and work not through expected interest. Also at the same time this could be useful as many teenagers interact with digital life. The purpose of studying this is to know how useful the counseling process could be. Is there also a possibility of implementing a counseling career in the current metaverse world as this is alleged to be the main digital mode in the future? Can a counseling career in the metaverse become a solution to resolve problems? How would this be according to religious (Islamic) views on this metaverse? This study uses literature with various source references. The results of this study were divided into two research questions, with each answer having several indicators to be used as a reference when dealing with adolescents in the future.
Keywords: Career counseling, Metaverse, Islamic Perspektive and Future Youth
The Perceptions of Nepotism and Political Participation in Students
Authors: Fitriani Annisa , Dwi Cahya Izzati Indah , Natalia Angga , Putri Cahyani Nadya
Published: September 2023

Society participation is the main system of support for a democratic political system. As elections are the main instrument of democracy they require high and quality participation for the realization of substantive democracy. The population in this study were students of the Economic Law Study Program, and faculty of Sharia UIN Raden Intan Lampung, class of 2019. The total was 223 students, and with a cluster random sampling technique a sample of 84 students were used. The measuring instrument in this study used a data collection method in the form of a Likert scale consisting of two scales, namely the Political Participation Scale, and the Nepotism Perception Scale. The data were analyzed using the product moment correlation technique assisted by the JASP 0.16.1.0 for the Windows program. The results showed a correlation value of r = 0.611 with a significant level of p = 0.000 (p <0.01) which means the hypothesis is accepted and there is a significant relationship between the Perception of Nepotism and Political Participation with R2 = 0.373. This states that the independent variable makes an effective contribution of 37.3%.
Keywords: Political Participation, Perceptions of Nepotism and Students.
Interreligious Education as an Approach to End Racism and Discrimination
Authors: Mohd Khambali Khadijah , Zaidi Daud Mohd , Thahir Andi
Published: September 2023

This study aims to explain that interreligious education can be used as an approach in dealing with diversity to end discrimination and racism in a multiethnic society. Interfaith education can increase students’ fears about changing religions or losing their own beliefs, as well as foster an understanding of other religions beyond history and culture, while allowing individuals to maintain their own beliefs. In addition, interreligious education must emphasize universal values or principles, such as peace and tolerance. It is a type of qualitative research with a library research model. Research data comes from related books and articles on interfaith education as an approach to ending discrimination and racism. Collection techniques were carried out through reading literature or written sources such as books, previous research, journals, and articles related to the research title. Data analysis with the content analyst. The results of this study state that interfaith education lays the foundation for education as an approach to fighting racism and discrimination. Thus, there is a need to consider religion and education in everyday life to promote more holistic interfaith education and build harmonious coexistence.
Keywords: interreligious education, racism, discrimination, common principals, harmonious co- existence, multiethnic society.
The Journey of Islamic Education in Universities in the Southern Frontier Provinces of Thailand and Their Response to the Global Crisis
Authors: Day Ma Chiraphan , Narongraksakhet Ibrahim
Published: September 2023

This study aims to describe the journey of Islamic education in universities in the border province of southern Thailand and how they respond to the global crisis. Is research with a qualitative approach to ethnographic methods of Realist ethnography, which is an objective view of information learned in the field and usually uses a third-person point of view. Data sources were obtained through interviews, field observations, and sociocultural phenomena. Based on the study of researchers, the results of the study concluded that the journey of Islamic education in ASEAN countries including the Southern Border Province of Thailand both Muslim majority and minority can be divided into four phases sequentially. First phase is the introduction phase. Second phase is when Islamic education faces external and global challenges. The third phase is when Islamic education is strong enough to face challenges and be able to solve problems. Fourth phase, Islamic education will provide all the solutions for the global crisis. By looking at the phases of the Journey of Islamic Education in Higher Education in the Southern Border Province of Thailand, will be able to provide all solutions for the global crisis.
Keywords: muslim, islamic education, global crisis
The Role and Challenges of Religion on Global Humanitarian Issues: An Islamic Perspective
Authors: Raden Aji Haqqi Abdurrahman
Published: September 2023

This research aims to describe the roles and challenges of religion in global humanitarian issues from an Islamic perspective. This research is a qualitative type of literature. Data sources were obtained from several scientific articles on this topic, which were accessed from e-journals. Meanwhile, data analysis was done using content analysis. The diversity of texts that motivate human work has led to proliferation of actions in a variety of areas: food aid, expansion of education and healthcare systems, water supplies, and slaves. zakat and waqf Those involved in work derive their human strength from the fact that financing for these structures is guaranteed, which also guarantees professionalism and efficiency, as it is well known that voluntary work has its limits.
Keywords: religious, islamic and human challenges
Work Ethos and Economic Welfare of the Fisherman Community of Way Tataan Sub-district Teluk Betung Timur
Authors: Badi'ah Siti , Dwi Anjani Dinda
Published: September 2023

The life of fishing communities is still far from the level of prosperity seen from the slum environment, low education, and minimum social sensitivity. This profession has been carried out for generations by their parents, there is no other job because of the limited skills and expertise they have. This study aims to describe the quality of work in creating prosperity. The method used in this paper is a descriptive qualitative method because it will describe a natural situation in obtaining data. The data in this manuscript were obtained through in-depth interviews. Based on the results of the research, it can be seen that the fishing community in the Way Tataan Village interprets the work ethic as being hardworking, diligent, and responsible. The condition of economic welfare is still quite minimal and not yet prosperous. Factors hindering the economic welfare of the fishing community in Way Tataan Village are low-human resources, limited capital, consumptive lifestyle, low catches, and detrimental to labor.
Keywords: economic welfare, fishermen, work ethics
Mediation of Social Skills on The Relationship between Tasawuf Values and Coping Strategy
Authors: . Suhandi , Wahyuni Citra , Diana Shella
Published: September 2023

Coping strategy define as how individuals respond to the problems as well manage the emotion and behavior when face the problems. Based on literature review, coping strategy is affected by religious aspect, which one of that is tasawuf values. There are still less research which showed how tasawuf values (illahiyyah, insaniyyah, and ‘alamiyyah) contribute to coping strategy. The purpose of this research is to find out mediation effect of social skills on the relationship between tasawuf values and coping strategy. This research use convenience technique sampling which sample has been collected is 148 students who has studied tasawuf course in the university. Data analysis which used in this study is conditional effect analysis with simple mediation model. Results showed that social skills partially mediated the relationship between tasawuf values and coping strategy with c’1 = 0.3000, p = 0.000. This findings emphasized the urgency of understanding tasawuf value for students in order to enhance social skills which eventually affect coping strategy.
Keywords: Tasawuf Value, Social Skills, Coping Strategy
Can Lexicographic Goal Programming, Artificial Neural Networks, and Value-at-risk Methods be Effective in Analysis of 50 Highest Trade Frequency Issuers Optimum Portfolio
Authors: Anwar L Nata Andrian , Riani Novi , Harris Allan , Anggraeni Erike
Published: September 2023

This study aims to describe the optimal stock portfolio as a series of processes for selecting a stock portfolio that suits the needs and desires of investors. The variable used is the daily closing price of the stock exchanges listed on the Indonesia Stock Exchange for the period September 1, 2016 to September 1, 2022 for 50 stocks with the highest trading frequency in the first quarter of 2022 using the value at risk, lexicographic goal method, programming, neural networks, and artificial neural networks. It is known that the value-at-risk method in generating shortfalls is carried out using a valuable approach that exceeds the threshold where the assumption of a 5% tail minimum return is generalized with the Pareto distribution. The input of the neural network in producing the output obtained through the PACF and ACF plots is t1. Issuer price forecasts are obtained using the neural network method and the backpropagation algorithm for each issuer, an SSMS of Rp. 1808.3, ICBP of Rp. 12,717, ASII Rp. 6832.1, BBNI of Rp. 6234.6, INCO of Rp. 2781.8, CPIN of Rp. 12,763, TLKM worth 2630.1, SCMA Rp. 2885.5, and WSKT worth Rp. 1575.7. The issuers obtained have a small MAPE value, which is below 10%. Programming the lexicographical objectives resulted in the nine selected issuers having a minimum standard of risk with maximum returns. Of the nine stocks selected, CPIN, SSMS, BBNI, ICBP, TLKM, ASII, INCO, SCMA and WSKT.
Keywords: return, value at risk, lexicographic goal programming, backpropagation
Improvement of the Community's Economy Through Waste Bank
Authors: Riani Novi , Harris Allan , Yuli Astut Sri , Handayani Agustia
Published: September 2023

The research aims to improve the community’s economy through waste banks. The research method is the method implemented by a researcher to collect, clarify data, and analyze the facts in place of research by using measurements and knowledge. The approach used by the authors in this study is sociological. Sociology is the scientific study of human social life. A narrative design is used in this research. Narratives aim to explore the lives of individuals and ask one or more individuals to provide stories about their lives. The results of this study indicate that the creation of a waste bank can be a solution for the community in handling waste so that it has a positive impact on the socio-economic life of the community. In addition, the existence of a waste bank has changed the mindset of the community regarding concerns in waste selection and collaboration between members to strengthen friendship so that the waste that previously had no value becomes something of economic value. While the problem with the waste bank occurs is the process, the amount of waste faced and the fleet that transports it makes the waste processing process hampered for the fleet and waste processing officers, the government’s lack of attention to the waste bank, the limited land to accomodate the collected waste, the price waste is unstable and often experiences a decline, reducing the enthusiasm of bank customers to save in the waste bank.
Keywords: economy, waste bank, improve the community’s economy through
Strengthening Local Culture as a Communication Strategy to Build Social Harmonization in Lampung Province
Authors: Yanti Fitri , Anggrainy Septy , Amaliah Eni , Nur Istiani Ade
Published: September 2023

This study aims to determine the strengthening of local culture and appropriate communication strategies to create social harmony and develop community social organizations where conflicts may occur. This study uses a qualitative method with a descriptive approach in Lampung province, which is famous for its diverse cultural wealth. Lampung province, especially in South Lampung and Central Lampung, is identified as having a high potential for conflict, where various tribes compete to maintain their cultural identity. From this study it was found that strengthening local culture through social interaction both with personal, cultural, and structural strategies as well as increasing community’s social organizations such as LKMD, PKK, and youth groups along with the active involvement of traditional and community leaders, is very necessary to minimize and resolve existing conflicts.
Keywords: local cultural, strategy of communication, social harmony