bluuebunny/crossref_metadata_2025 huggingface dataset:
A Simplified Prediction Model for End-stage Kidney Disease in Patients With Diabetes
Authors: Inoguchi Toyoshi , Okui Tasuku , Nojiri Chinatsu , Eto Erina , Hasuzawa Nao , Inoguchi Yukihiro , Ochi Kentaro , Takashi Yuichi , Hiyama Fujiyo , Nishida Daisuke , Umeda Fumio , Yamauchi Teruaki , Kawanami Daiji , Kobayashi Kunihisa , Nomura Masatoshi , Nakashima Naoki
Published: March 2022

This study aimed to develop a simplified model for predicting end-stage kidney disease (ESKD) in patients with diabetes. The cohort included 2,549 individuals who were followed up at Kyushu University Hospital (Japan) between January 1, 2008 and December 31, 2018. The outcome was a composite of ESKD, defined as an eGFR < 15 mL min− 1 [1.73 m]−2, dialysis, or renal transplantation. The mean follow-up was 5.6 \(\pm\) 3.7 years, and ESKD occurred in 176 (6.2 ) individuals. Both a machine learning random forest model and a Cox proportional hazard model selected eGFR, proteinuria, hemoglobin A1c, serum albumin levels, and serum bilirubin levels in a descending order as the most important predictors among 20 baseline variables. A model using eGFR, proteinuria and hemoglobin A1c showed a relatively good performance in discrimination (C-statistic: 0.842) and calibration (Nam and D’Agostino \(\chi\)2 statistic: 22.4). Adding serum albumin and bilirubin levels to the model further improved it, and a model using 5 variables showed the best performance in the predictive ability (C-statistic: 0.895, \(\chi\)2 statistic: 7.7). The accuracy of this model was validated in an external cohort (n = 5,153). This novel simplified prediction model may be clinically useful for predicting ESKD in patients with diabetes.
Novel nannofossils extraction methodology from paintings coupled with GC-MS for provenance determination and binder analysis
Authors: Jaques Victory Armida Janine , Trubač Jakub , Rathousky Jiři , Cajthaml Tomáš , Holcová Katarina
Published: March 2022

Calcareous nannofossils for provenance analysis is a new-old topic for cultural heritage. Several studies already mentioned it for ceramic but less for paintings. Preparatory layers of the paintings are often made with chalk which is composed of microfossils. In order to extract the calcareous nannofossils assemblage from these layers, we need to disaggregate it. Actually, the method is to plunge the micro-samples into the water and heat it if the water alone does not work. The resulting disaggregation takes long and is not efficient in terms of quantitative results or time. In this work, we aimed to develop a disaggregation method that will extract the most nannofossils from the preparatory layer with the least destruction. As these samples are unique and we should make the most of them, we observe if gas chromatography-mass spectrometer analysis could be done on the disaggregated sample in order to determine the binders after the nannofossils retrieval. The method we are presenting is relatively easy to use, can be applied for most paintings and have a low impact on binders for their determination.
The Clinical Frailty Scale As Useful Tool In Patients With Brain Metastases
Authors: Kerschbaumer Johannes , Krigers Aleksandrs , Demetz Matthias , Pinggera Daniel , Klingenschmid Julia , Pichler Nadine , Thomé Claudius , Freyschlag Christian F.
Published: March 2022

Purpose: The Clinical Frailty Scale (CFS) evaluates patients’ level of frailty on a scale from 1 to 9 and is commonly used in geriatric medicine, intensive care and orthopedics. The aim of our study was to reveal whether the CFS allows a reliable prediction of overall survival (OS) in patients after surgical treatment of brain metastases (BM) compared to the Karnofsky Performance Score (KPS).Methods: Patients operated for BM were included. CFS and KPS were retrospectively assessed pre- and postoperatively and at follow-up 3-6 months after resection.Results: 205 patients with a follow-up of 22.8 months (CI95%, 18.4-27.1) were evaluated. CFS showed a median of 3 (“managing well”; IqR 2-4) at all 3 assessment-points. Median KPS was 80 preoperatively (IqR 80-90) and 90 postoperatively (IqR 80-100) as well as at follow-up after 3-6 months. CFS correlated with KPS both preoperatively (r=-0.92; p<0.001), postoperatively (r=-0.85; p<0.001) and at follow-up (r= -0.93; p<0.001). The CFS predicted the expected reduction of OS more reliably than the KPS at all 3 assessments. A one-point increase (worsening) of the preoperative CFS translated into a 30% additional hazard to decease (HR=1.30, CI95% 1.15-1.46; p<0.001). A one-point increase in postoperative and at follow-up CFS represents a 39% (HR=1.39, CI95% 1.25-1.54; p<0.001) and of 42% risk (HR= 1.42, CI95% 1.27-1.59; p<0.001).Conclusion: The CFS is a feasible, simple and reliable scoring system in patients undergoing resection of brain metastasis. The CFS 3-6 months after surgery specifies the expected OS more accurately than the KPS.
Health-related Quality of life of non-obese women with polycystic ovary syndrome treated with D-Chiro-Inositol: The case series study
Authors: Turnic Tamara Nikolic , Simic Dusan , Reshetnikov Vladimir , Mikerova Maria , Ekkert Natalia , Jakovljevic Biljana , Bolevich Stefani , Vesic Zoran , Bicanin-Ilic Marija , Dimitrijevic Aleksandra , Djuric Dusan , Jakovljevic Vladimir
Published: March 2022

Background: Myo- or D-chiro-inositol (DCI) therapy can be used in PCOS as monotherapy or as a combination with other treatment modalities. Interestingly, since the treatment with DCI or similar could be effective in unknown level, often usage of inositol could be connected with psychological consequences, especially regarding the quality of life. We hypothesized that quality of life is changed in women with PCOS, and the DCI treatment could affect some aspects of life, even as a placebo. The main aim of this qualitative research designed as case series was to explore health‐related quality of life (HRQoL) among non-obese women with polycystic ovary syndrome (PCOS) before and after DCI treatment Results: In our study, item’s score related to menstrual problems and emotions differed the most, so we can observe that the use of DCI had the greatest impact on the intensity of menstrual problems. Also, the feelings related to changes in body weight of the participants also differed after a three-month period, which does not have to be a consequence of the applied supplementation, because we know that there was no change in body weight. Namely, a statistically significant difference was observed in the occurrence of menstrual problems before and after three months of treatment with DCI, while there were no changes in other domains of HRQoL. Interestingly, supplementation led to the alleviation of menstrual problems in most subjects which could not be a placebo effect of DCI. Conclusion: Overall, PCOS has a negative impact on the HRQoL of women in reproductive period. Weight, hirsutism, infertility and menstrual problems appeared to be most affected rather than areas of physical functioning. Definitely, all HRQoL measurements taken before DCI treatment were worse in comparison with the status after treatment in the same group of women with PCOS.
Correlation of Tumor-Infiltrating Neutrophils and Tumor-Infiltrating Lymphocytes with Early Recurrence in Patients with Non-Muscle Invasive Bladder Urothelial Carcinoma (Short-Term Prospective Cohort Study)
Authors: Shalaby Essam , Salem Omar , Nashar Ahmed El , El-Tobgy Ahmed
Published: March 2022

Background
Tumor-infiltrating neutrophils (TINs) and lymphocytes (TILs) play essential roles in promoting or combating various neoplasms, the prognostic value of TILs, TINs and neutrophil to lymphocyte ratio (NLR) in bladder cancer (BC) is still unconcluded.
Aim
To investigate the association between TINs and CD8 + T-lymphocytes, as well as NLR with progressive non-muscle invasive urothelial bladder carcinoma (NMIBC).
Methods
Patients with newly diagnosed NMIBC underwent transurethral resection of bladder tumor (TURBT) followed by a standard BCG regimen, follow-up cystoscopy was performed every 3-months for the first 2-years. Tumor characteristics and histopathological examination were documented. As regards immunohistochemical evaluation, the tumors categorized into two main groups: high or low, according to their TINs, and CD8 + T-lymphocytes immunohistochemically expression and NLR. Kaplan-Meier estimates were used to compare the recurrence-free survival.
Results
104 patients with NMIBC were included; Ta and T1 represented 23.1% and 76.9% of patients respectively. High-grade (HG) and low-grade (LG) were 53.8% and 46.2%, respectively. Tumor recurrence and progression were correlated to a higher stage and grade (p = 0.05). Regardless stage and grade; recurrence was more likely to occur in high TINs and TILs groups, while progression was more likely in high TILs and NLR (p < 0.05). In Ta LG tumours, the higher TINs and NLR were associated with higher recurrence rate. In T1 (LG) tumour; low TINs, high TILs, and low NLR were associated lower recurrence and progression rate, In T1 HG tumours; high TINs and NLR were associated clinical and statistically lower recurrence rate. Kaplan-Meier survival analysis showed that TINs and TILs were significantly related to the short recurrence free survival (RFS) (p = 0.03, p = 0.001).
Conclusion
TINs, CD8 + lymphocytes and NLR are important prognostic predictors in patients with NMIBC. Recurrence was more likely to occur in the high TINs and TILs groups, while higher TILs and NLR were correlated to tumour progression.
Theaflavin 3-gallate inhibits the main protease (Mpro) of SARS-CoV-2 and reduces its count in vitro
Authors: Chauhan Mahima , Bhardwaj Vijay Kumar , Kumar Asheesh , Kumar Vinod , Kumar Pawan , Enayathullah M. Ghalib , Thomas Jessie , George Joel , Kumar Bokara Kiran , Purohit Rituraj , Kumar Arun , Kumar Sanjay
Published: March 2022

Main protease (Mpro) of SARS-CoV-2 is crucial for its replication/infection and has been recognized as an attractive drug target. In this study, we identified theaflavin 3-gallate as an inhibitor of Mpro protein of SARS-CoV-2 with IC50 value of 18.48 ± 1.29 µM. Compared to theaflavin, theaflavin 3-gallate exhibited superior antiviral activity and at a concentration of 200 µM reduced the viral count by 75% (viral particles reduced from 106.7 to 106.1). Time-dependent analyses of conventional and steered MD-simulations revealed stronger interactions of theaflavin 3-gallate with the active site residues of Mpro than the standard molecule GC373 and theaflavin. Taken together, our findings suggest that theaflavin 3-gallate can be developed into a potential lead molecule against SARS-CoV-2.
Primary Intraocular Lymphoma Masquerading as Unilateral Hypopyonic Anterior Uveitis: A Case Report
Authors: Zamani Ghodsieh , Hajipour Atefeh , Ganjeifar Babak , Ebrahimiadib Nazanin , Hosseini Seyedeh Maryam
Published: March 2022

Purpose: To report an unusual case of unilateral anterior segment large B-cell intraocular lymphoma (IOL) presenting as a recurrent hypopyonic anterior uveitisCase Presentation: A 55-year-old female was referred because of recurrent unilateral anterior hypopyonic uveitis with partial response to topical corticosteroid. All of the laboratory tests, review of systems and ocular sampling results were unremarkable. Finally, with probability of masquerading syndromes cytological specimens were obtained 3 times and the last sample showed large B cell lymphoma. However, posterior segment of the eyes has never involved during 18 months’ follow-up. First, it appeared confined to the eye and initially responded favorably to local chemotherapy (methotrexate and rituximab) but later went on to develop systemic involvement. CNS lymphoma was detected in the third brain MRI 6 months following ocular involvement. At this time, systemic chemotherapy was started. In the last 18 months’ follow-up, visual acuity was 20/30 in the right eye without posterior segment or fellow eye involvement. Conclusion: Unusual presentation of PIOL as a unilateral isolated anterior hypopyonic uveitis should be kept in mind. This report emphasizes the importance of precise work-ups and multiple ocular biopsies to confirm the diagnosis of intraocular lymphoma.
New formulas for the trigonometry of isosceles triangles
Authors: King Noah
Published: March 2022

This paper discusses a new formula to solve for the angle of isosceles triangles given proportion of differentiated unequivalent edge length versus the always-equivalent edges. The equation is equal to the arcsine of (X/2) multiplied by two. This formula is to be called ‘isn^-1(x)’, short for inverse isosceles sine equivalent. Also discussed is the non-inverse ‘isn(x)’ which is the cyclic function which is determined to correspond as the equivalent of the classic sine formula to isosceles triangles. The formula set is clearly superior and powerful at calculating the angle and measure of any given obtuse or acute triangle of an unclassified type, as well as unifying a simplest-fit formula across all types of triangle.
Prognostic Factors in Preterm Infants with Neonatal Gastrointestinal Perforation: A Retrospective Cohort Study
Authors: Yuan Peng , Huang Yao , Wang Yi
Published: March 2022

Background
Gastrointestinal perforation (GIP) among neonates is a major clinical emergency associated with high mortality, which is severe and life-threatening, especially in preterm infants. This study aimed to describe the clinical features of preterm neonatal gastrointestinal perforation and evaluate the potential prognostic factors.
Methods
A total of 191 preterm neonates with gastrointestinal perforation were included in this retrospective cohort study and assigned to survival and non-survival groups. Information containing clinical and demographic data, laboratory and imaging features, and outcomes were collected and recorded by retrospective medical records review. The independent factors associated with death risk were determined by univariate and multivariate logistic regression analyses.
Results
The overall mortality in the study cohort was 25.1%. The median age of onset of gastric perforation was 3 days (range: 1–11 days), while the median age of onset of intestinal perforation was 7.5 days (range: 1–30 days). Abdominal distension (184 [96.3%] patients) was the most common symptom, followed by absent bowel sounds (157 [82.2%] patients), lethargy (148 [77.5%] patients), and shortness of breath (60 [59.4%] patients). Finally, three independent mortality risk factors were identified: severe acidosis (OR,7.604; 95% CI, 1.424‒51.910; p = 0.025), shock (5.131; 2.419‒11.266; p < 0.001) and coagulopathy (3.269; 1.511–7.431; p = 0.003).
Conclusions
Severe acidosis, shock, and coagulopathy are independently and significantly associated with an increased risk of death in preterm infants with neonatal gastrointestinal perforation. The identification of novel risk factors will facilitate the development of therapeutic strategies for preterm neonates with gastrointestinal perforation.
Effect of paramagnetic impurities on superconductivity in polyhydrides: s-wave order parameter in Nd-doped LaH10
Authors: Semenok Dmitrii V. , Troyan Ivan A. , Sadakov Andrey V. , Zhou Di , Galasso Michele , Kvashnin Alexander G. , Kruglov Ivan A. , Bykov Alexey A. , Terent’ev Konstantin Y. , Cherepahin Alexander V. , Sobolevskiy Oleg A. , Pervakov Kirill S. , Seregin Alexey Yu. , Helm Toni , Förster Tobias , Grockowiak Audrey D. , Tozer Stanley W. , Nakamoto Yuki , Shimizu Katsuya , Pudalov Vladimir M. , Lyubutin Igor S. , Oganov Artem R.
Published: March 2022

Polyhydrides are a novel class of superconducting materials with extremely high critical parameters, which is very promising for applications. On the other hand, complete experimental study of the magnetic phase diagram for the best so far known superconductor, lanthanum decahydride LaH10, encounters a serious complication because of the large upper critical magnetic field HC2(0), exceeding 120–160 T. Partial replacement of La atoms by magnetic Nd atoms results in a decrease of the upper critical field, which makes it attainable for existing pulse magnets. We found that addition of neodymium leads to significant suppression of superconductivity in LaH10: each atomic % of Nd causes decrease in TC by 10–11 K. Using strong pulsed magnetic fields up to 68 T, we constructed the magnetic phase diagram of the ternary (La,Nd)H10 superhydride, which appears to be surprisingly linear with HC2 ∝ |T – TC|. The pronounced suppression of superconductivity in LaH10 by magnetic Nd atoms and the robustness of TC with respect to nonmagnetic impurities (e.g., Y, Al, C) under Anderson’s theorem indicate the isotropic (s‑wave) character of conventional electron-phonon pairing in the synthesized superhydrides.
FDP Fluctuation in Severe COVID-19 is Associated With the Development of Thrombotic or Bleeding Complications and Systemic Coagulopathy
Authors: Matsumoto Hironori , Kikuchi Satoshi , Murata Satoru , Ohshita Muneaki , Harima Yutaka , Annen Suguru , Mukai Naoki , Nakabayashi Yuki , Konishi Saki , Ogawa Shirou , Okita Mitsuo , Takeba Jun , Sato Norio
Published: March 2022

Purpose COVID-19 is sometimes associated with coagulation disorders. In such cases, patients developed elevated D‐dimer and fibrin degradation products (FDP) levels, both of which are associated with high risks of thromboembolic complications and poor prognosis. To date, time course changes of FDP values in COVID-19 patients has not been well evaluated. The aim of this study is to evaluate whether FDP fluctuation in COVID-19 patients are associated with systemic coagulopathy.Methods We retrospectively analyzed the changes in coagulofibrinolytic markers including FDP in 42 COVID-19-ARDS patients. FDP elevation as the fluctuation was defined as follows: 1) FDP>10μg/mL for the first time after admission and 2) 10μg/mL or more elevation after the improvement of the first or subsequent FDP elevations. Results FDP elevation was observed a total of 30 times in 21 patients (50%). Marked intravascular coagulofibrinolytic activation occurred at the same time as the FDP elevation (soluble fibrin: SF, 27.0 [14.9–80.0] μg/mL; thrombin-antithrombin complex: TAT, 7.5 [2.9–17.8] μg/L; plasmin-α2-plasmin inhibitor complex: PIC, 2.4 [1.4–4.2] μg/mL). FDP was elevated in all patients who met sepsis-induced coagulopathy (SIC) or disseminated intravascular coagulation (DIC) diagnosis criteria. Thrombotic or bleeding complications developed in 12 patients (28.6%) and were significantly correlated with FDP elevation (OR [odds ratio] 4.50, 95% CI [confidence interval] 1.01–20.11, p = 0.049). However, there were no significant differences in coagulofibrinolytic activities between the patients with and without SIC or DIC. Conclusions Coagulation activation which can lead to the development of systemic coagulopathy such as DIC occurred with FDP fluctuation in severe COVID-19 patients. However, there is a limit of the application of existing DIC and SIC diagnosis criteria to COVID-19.
Full-state time-varying asymmetric constraint control for non-strict feedback nonlinear systems based on dynamic surface method
Authors: yang zhongjun , dong chuyan , zhang xinyu , wang guogang
Published: March 2022

We investigate the tracking control problem for the class of the non-strict feedback nonlinear system with external disturbance and time-varying asymmetric full state constraints. Firstly, the unknown nonlinear term with external disturbance in the system are estimated by fuzzy logic system. The backstepping method is applied to the design of adaptive fuzzy controller. However, to prevent that the constraints are overstepped. By introducing novel tan-type time-varying asymmetric barrier Lyapunov function (TABLF) in each step of backstepping design. Secondly, the dynamic surface control (DSC) is introduced in the algorithm design to solve the complex problem of controller caused by the derivative of virtual control value. The proposed control scheme can speed up the tracking speed of the system. Compared with the previous work, it is verifified that the combination of DSC and TABLF can obtain good performance within the constraint range, and can ensure fast and stable tracking convergence under external disturbance. Finally, two simulation examples verify the performance of the adaptive controller.
Antibacterial Activity of Garlic (Allium Sativum) on Salmonella, Shigella, and E. Coli
Authors: Bekele Damtew , Gebisa Guta
Published: March 2022

Background
This experiment was conducted to see if garlic would inhibit the growth of Salmonella, Shigella and E. coli. This helps to understand the effectiveness of home remedies such as natural herbs includes garlic for medicinal purpose.
Methods
This study focuses on significant antibacterial activity of garlic (Allium sativum) extract against gram negative bacteria like Salmonella, Shigella and E. coli. The plant parts are known to have antimicrobial activity on bacteria which are known to be pathogenic to animals in general and to human in particular. The plant extracts were inoculated on prepared media of microbial culture contains Salmonella, Shigella and E. coli species.
Results
The result obtained indicates garlic has strong effective on Salmonella by reducing number of colonies that survive due to exposure of the anti-microbial agent is approximately similar to that of Salmonella but E. coli species showed some percent of resistance in comparison to Salmonella and Shigella.
Conclusions
The result obtained from this study could serve as an evident that Ethiopian traditional medicinal plants have a great effectiveness on different pathogenic organism.
Diabetic foot infection caused by Burkholderia cepacia complex: Report of an unusual case with a scoping literature review
Authors: Leme Rodrigo Cuiabano Paes , Chaves Jéssica Reis Esteves , Gonçalves Luiz Carlos Soares , Alvim Leonardo César , de Almeida João Roberto Chaves , Renó Leonardo da Cruz
Published: March 2022

According to previous publications, Burkholderia cepacia complex (BCC) species are widely described pathogens in cystic fibrosis (CF) patients but not in individuals with diabetes mellitus (DM). We report a diabetic foot infection caused by BCC in a 42-year-old male patient who responded clinically after surgical debridement and meropenem monotherapy. In addition, a scoping review was constructed to map BCC infections in patients with DM.
Mathematical Modeling and Analysis of Alcoholism Epidemics: A Case Study in Ethiopia
Authors: Satana Tesfaye Sama , Kassaye Masreshaw Temere
Published: March 2022

In this paper, we developed deterministic mathematical model of alcoholism epidemics. First, the existence and uniqueness of the formulated model will be studied to show the well-possedness of the model. Second, the major qualitative analysis like alcoholic free equilibrium point (E0), endemic equilibrium point (E*), basic reproduction number (R0), were computed. From the stability analysis, we found that an alcoholic free equilibrium point is locally asymptotically stable if R0 < 1. The global asymptotic stability of alcoholic free equilibrium point is established using LaSalle's invariance principle of Lyapunov functions. The sensitivity of model parameters is done using normalized forward sensitivity index. At the end, numerical simulations on the study were conducted using the ODE 45 to confirm our analytic results. It is pointed out that, minimizing the contact rate between the non-drinkers and heavy drinkers, maximizing the number of drinkers that go into treatment can be useful in combating the alcoholism epidemic.
Overweight Effects on Metabolic Rate, Chronic Diseases, Time Perception, Aging, and Lifespan: a Systematic Review
Authors: Oshakbayev Kuat , Bedelbayeva Gulnara , Gazaliyeva Meruyert , Dukenbayeva Bibazhar , Tordai Attila
Published: March 2022

Background: The hypothesis that metabolic rate is inversely correlated with lifespan has long been debating. Another area of controversy is an evidence of a relationship between metabolic rate (MR) and time-flow perception (TFP), and aging. Aim: to study the impact of overweight and food intake on MR, TFP, chronic diseases, aging, lifespan; difficulties in weight loss.Methods. Design: a systematic review. Settings: Web of Science, Scopus, Science Direct, Kopernio, PubMed, Mendeley were searched for articles published from January 1979 until February 2022. The study bases on a viewpoint supported by a systematic literature review of 3612 articles published worldwide.Results: In total, 107 full-text articles were assessed for eligibility. From them, 22 articles were excluded with reasons. Overweight and overeating accelerate MR, leading to hyper-metabolic mode of the body. MR and lifespan are inversely correlated. TFP depends on MR; accelerated MR leads to deceleration of TFP. Every person has an individual ability to gain weight up to 'maximum bodyweight', which indicates the individual potential energy to weight gain. Overweight excessively consumes the body ‘vital energy’, is a soil to grow diseases; devours body potential energy. Weightloss creates ‘body power to weight gain’ that increases physical/mental activity, recovering from diseases, or weight regain. The body needs less calorie intake due to the decrease in MR by age. For weight loss should use very-low-calorie diets and manage metabolic intoxication.Conclusions: Our findings support that overweight and overeating increase metabolic rate, which delays time-flow perception, accelerates aging, limits lifespan. For weight loss should manage very-low-calorie diets.
Metal Artefact Reduction Sequences (MARS) in Magnetic Resonance Imaging (MRI) After Total Hip Arthroplasty (THA). A Non-Invasive Approach for Preoperative Differentiation Between Periprosthetic Joint Infection (PJI) and Aseptic Complications?
Authors: Busch André , Jäger Marcus , Beck Sascha , Wegner Alexander , Portegys Erik , Wassenaar Dennis , Theysohn Jens M , Haubold Johannes
Published: March 2022

Background:In the past, radiographic imaging was of minor relevance in the diagnosis of periprosthetic joint infections (PJI). Since metal artefact reduction sequences (MARS) are available, magnetic resonance imaging (MRI) has become a promising diagnostic tool for the evaluation of hip arthroplasty implants. The purpose of the present study was to evaluate the efficacy of MARS MRI in comparison to established diagnostic tools to distinguish between aseptic failure and PJI.Methods:Between July 2018 to September 2019, MARS-MRI was conducted using the optimized parameters at 1.5 T in a coronal and axial STIR (short-tau-inversion recovery), a non-fat-saturated T2 in coronal view and a non-fat-saturated T1 in transverse view in 45 patients with painful hip after THA.Results:Synovial layering and muscle edema were significant features of periprosthetic joint infection, with sensitivities of 100% and specifities of 63.0 - 75.0%. The combined specifity and sensitivity levels of synovial layering and muscular edema was 88.0% and 90.0%. Granulomatous synovitis was a significant feature for aseptic failure, with 90.0% sensitivity and 57.0% specifity.Conclusion:MARS-MRI is as suitable as standard diagnostic tools to distinguish between aseptic failure and PJI in patients with a total hip arthroplasty (TJA). Further studies with larger patient numbers have to prove whether MARS-MRI could be integral part of PJI diagnostic.
Integrative Analysis of LncRNAs and miRNAs, Revealing Key Biomarkers of Condyloma Acuminata
Authors: Zhong Yixiu , Song Weicheng , Wang Qi , Liang Keyi , Zeng Kang
Published: March 2022

Condyloma acuminata (CA), genital wart, is caused by HPV infections and transmitted by sexual contact. Bioinformatics analyses contributes to the discovery of hub genes and non-protein-coding RNAs of novel therapeutic relevance in CA. We screened out dysregulated miRNAs and LncRNAs in gene expression matrix of our own dataset and datasets from Arrayexpress database, GEO database and. Subsequently, miRNA- gene network and LncRNAs-miRNA interaction pair were constructed. Hub genes were identified from PPI network of target genes. It was predicted RP11-1081L13.4 and MIR31HG commonly interacted with miR-31a-5p, which is up regulated in CA. Functional enrichment analyses of GO and KEGG revealed the potential role of MAPK pathways in CA. RT-qPCR results showed that miR-31-5p was over-expressed in CA tissues. Downregulated miR-31-5p increased apoptosis and reduced proliferation and migration ability of Hela cell lines in vitro via downregulating MAPK pathway. These findings suggested that MIR31HG, RP11-1081L13.4, especially miR-31-5p and hub genes were promising biomarkers, contributing to CA pathogenesis.
Politeness in Human-Robot Interaction: A Multi-Experiment Study with Non-Humanoid Robots
Authors: kumar shikhar , Itzhak Eliran , Edan Yael , Nimrod Galit , Sarne-Fleischmann Vardit , Tractinsky Noam
Published: March 2022

We studied politeness in human-robot interaction based on Lakoff’s politeness theory. In a series of eight studies, we manipulated three different levels of politeness of non-humanoid robots and evaluated their effects. A table-setting task was developed for two different types of robots (a robotic manipulator and a mobile robot). The studies included two different populations (old and young adults) and were conducted in two conditions (video and live). Results revealed that polite robot behavior positively affected users' perceptions of the interaction with the robots and that participants were able to differentiate between the designed politeness levels. Participants reported higher levels of enjoyment, satisfaction, and trust when they interacted with the politest behavior of the robot. A smaller number of young adults preferred the politest behavior of the robot compared to old adults. Enjoyment and trust of the interaction with the robot were higher when study participants were subjected to the live condition compared to video and when they interacted with a mobile robot compared to a manipulator respectively.
Tuberculosis Immunodiagnosis System: Analysis of Potential Losses of Patients for Registration
Authors: Sterlikov S. A. , Kаzykinа T. N.
Published: March 2022

The objective: to develop proposals to improve the effectiveness of the tuberculosis immunodiagnosis system in children by analyzing potential losses of patients for registration.

Materials: data from primary medical records of 605 children in 5 regions of Russia, results of the survey in 513 legal guardians and 27 experts.

Results. 13.9% of the children subject for screening were not examined, tests were administered in 1.1% of children who had contraindications to them, errors in the test administration were expected in 1.5% of children, and in 6.2% of children, antihistamine medications were used leading to errors in the detection of tuberculosis infection. In 3.7% of children, results of the test were not assessed, 3.1% of eligible children were not referred to the phthisiologist, and 6.5% were lost to follow-up by the phthisiologist.

Conclusions. The cumulative loss during immunodiagnosis of tuberculosis made 68.7%. The main reasons for the losses are medical exceptions and refusals to have immunodiagnosis of tuberculosis by legal guardians, incomplete follow-up by the phthisiologist, and the use of antihistamines.

To reduce these losses, it is advisable to consider the following: organizing consultation with the phthisiologist at children's polyclinics and large children's groups; legal guardians should be able to have a paid sick leave on the days when the child has an appointment with the phthisiologist; specifying indications for desensitizing therapy and prohibiting it outside the indications; organizing internal and external quality control system for immunodiagnostics.
A Clinical Case of Pulmonary Lymphangioleiomyomatosis
Authors: Kazakova S. S. , Аftaeva E. V. , Zinovieva Z. V.
Published: March 2022

The article describes a clinical case of pulmonary lymphangioleiomyomatosis (LAM) in a 44-year-old female Patient N., who has been suffering from this disease for a long time. It depicts characteristic classic signs of LAM – a progressive course, thin-walled air cavities in the lungs, retroperitoneal lymphadenopathy, and recurrent pneumothoraxes.
Family support, psychological capital, and start-up formation
Authors: Ononye Uzoma , Ofili Peter , Ndudi Francis , Chukwujioke Agbim Kenneth
Published: March 2022

The influence of family support and psychological capital (PsyCap) is a topical discourse in entrepreneurship studies due to the unsupportive and turbulent environments most entrepreneurs operate in. However, studies concluding on the nature and direction of family support and PsyCap effects on start-up formation appear scant. This study aims to empirically examine family support effects on start-up formation with psychological capital (PsyCap) as a mediation factor. Specific emphasis was given to extended family support. The study utilized the partial least square (PLS) method for hypotheses testing with cross-sectional data collected from 261 randomly sampled trainees in an entrepreneurship training program organized by the Delta State Ministry of Youth Development. The PLS analysis showed that family support (β = 0.317, p = 0.000) and PsyCap (β = 0.202, p = 0.000) have a significant positive effect on start-up formation. The results proved that family support and PsyCap are valuable antecedent factors for positioning entrepreneurs to engage and thrive productively in the start-up formation process. Furthermore, PsyCap did not mediate the significant positive effect of family support on start-up formation (β = 0.235, p = 0.000; β = 0.103, p = 0.052). This result demonstrates that family support may not be enough for PsyCap to transmit its significant positive effect on start-up formation. Hence, there is a need to procure other alternate support from formal or informal settings.
The efficacy and safety study of the combined use of platelet-rich plasma and fractional radiofrequency ablation in the treatment of post-acne scars
Authors: Blyumina V. A. , Ostretsova M. N. , Jardali N. A.
Published: March 2022

Introduction.So far, a large number of skin scars treating methods have been proposed and tested. The use of platelet-rich plasma (PRP) is currently being considered as one of the most promising approaches to skin scar treatment.

Aim.Clinical efficacy and safety evaluation of complex treatment of post-acne scars using PRP.

Materials and methods.An open, randomized, prospective study was conducted in parallel groups. The study included 78 patients with post-acne scars, then randomized into 2 groups. Group 1: 36 patients receiving platelet-rich plasma (PRP); group 2: 42 patients receiving complex treatment with PRP and fractional radiofrequency ablation (PRP + FRF). PRP procedures using the micro-papular technique in group 1 were carried out 5 times with an interval of 2 weeks. The combination of PRP + FRF in group 2 was performed according to the following: the first procedure – FRF, two weeks later – PRP using the micro-papular technique. Then after 2 weeks FRF was performed again, and so on. The total number of procedures of both techniques was 10.

Results and discussion.As a result of the treatment, in all patients with post-acne, the clinical indicators of the severity of skin scarring changes decreased significantly, while the most noticeable dynamics were common for patients in group 2. The scars assessment using the Vancouver scale showed that 6 and 12 months after treatment, the severity of objective components and the severity of subjective sensations decreased in most patients. The severity of their own attitude to persistent defects also decreased. Analysis of the frequency of adverse reactions during treatment and in the early period showed that there were no significant intergroup differences in individual adverse reactions. The overall frequency of adverse events in the long-term period also did not significantly differ.

Conclusion.The results of the study indicate that the use of PRP in the complex treatment of scarring is a clinically effective and safe method of treatment and allows you to expand the range of therapeutic approaches for scarring skin deformities.
Nail psoriasis: dynamics of the clinical course during anti-IL-17 therapy
Authors: Zhukova O. V. , Artemyeva S. I. , Al-Hawatmi A.A.-H.M.
Published: March 2022

Psoriasis is a chronic immune-mediated inflammatory disease in which the pathological process quite often involves the nail apparatus. Psoriatic onychodystrophy is considered a serious psychological and social problem, as nail lesions are not only a cosmetic defect, they can also complicate daily activities, including employment, ability to work and generally impair the quality of life of patients. In addition, numerous studies and clinical practice show that nail lesions in psoriasis are also associated with a more severe course of the skin process, and are rather torpid to therapy. Moreover, psoriatic onychodystrophy is considered as a form of enthesitis, which is in fact an important predictor of the development of psoriatic arthritis. Various topical, systemic and physiotherapeutic options have been recommended in the therapy of psoriasis with nail plate damage, but the effectiveness of these therapeutic methods is in most cases insufficient and the search for highly effective treatment is of great clinical importance at present. Taking into consideration the critical importance of interleukin (IL)-17 in the pathogenesis of psoriasis, its inhibitors allow to achieve a stable remission of cutaneous and joint processes, thus, it is promising in the therapy of psoriatic onychodystrophy. The article presents the literature data on epidemiology, clinical picture of nail changes in psoriasis, the review of effective pathogenetic methods of psoriatic onychodystrophy therapy and personal clinical observations of patients with severe psoriasis with nail plate damage treated with Russian interleukin 17A inhibitor – Netakimab. These observations allow to draw a conclusion about high efficacy of netakimab in the therapy of patients with psoriasis including the presence of such hardtop-treat localizations as nail lesions.
Violation of the skin barrier in patients with allergic dermatoses: causes, consequences, possibilities of correction
Authors: Tlish M. M. , Naatyzh Z. Yu. , Kuznetsova T. G.
Published: March 2022

The article considers the topical dermatological issue concerning the breach of the integrity of the skin’s barrier in patients with allergic dermatosis. The horny layer of the skin in such patients can be broken as a result of numerous external causes: excoriations, injuries, allergens, irritants, etc. These factors, in turn, contribute to the activation of endogenous dermal proteases and decrease in the synthesis of epidermal lipids, which leads to reduced elasticity of corneocytes, increased intercellular spaces, and facilitates access for antigenic stimulants that promote the development of inflammation. The decrease in the skin’s barrier is accompanied by the development of immune inflammation, production of pro-inflammatory cytokines that inhibit the generation of antimicrobial factors, induce hyperplasia and apoptosis of keratinocytes. The integral approach plays a leading role in the treatment of the disease due to the specifics of the pathogenesis and course of allergic dermatoses. In the practice of a dermatologist, topical glucocorticosteroids occupy an important place. With their help, it is possible to quickly cope with the symptoms of inflammation in many dermatoses.

The introduction presents current literature data on the role of skin ceramides in the restoration of the epidermal barrier. It is indicated that the epidermis of patients suffering from various dermatoses is characterized by a decrease in the production and dysfunction of physiological lipids, and, therefore, is prone to an increase in the incidence of pathological skin changes. Therefore, in allergic dermatoses, it is preferable to use products containing ceramides in their composition, which reduce transepidermal moisture loss, strengthen the structures of the epidermal barrier, and allow further elimination of relapses of the disease and improve the quality of life of patients.
CONTRASTIVE ANALYSIS OF THE VOCABULARY OF POPULAR AND ACADEMIC SCIENTIFIC PAPERS IN THE FIELD OF THEOLOGY IN THE SERBIAN LANGUAGE
Authors:   University of Belgrade Faculty of Orthodox Teology, A. Knežević Ivana
Published: March 2022

The specific traits of the methodology of theology as well as the peculiarities of its scientific knowledge inevitably inﬂuence the extralinguistic and intralinguistic features of theological scientific works, which is especially reﬂected in the lexical layer. Tis paper deals with the analysis of the vocabulary of popular scientific theological works of eminent authors in the Serbian language in relation to academic papers as basic representatives of the scientific style of theology. The results obtained by statistical analysis of the vocabulary of the works of the two mentioned substyles enabled their contrastive analysis. In addition, atypical elements were pointed out – the expressive and emotional markers and stylistic figures of popular science theological works.
THE LEXICAL MEANS FOR THE DESCRIPTION OF THE 1999 NATO BOMBING OF YUGOSLAVIA IN THE GERMAN AND SERBIAN PRESS
Authors:   University of Kragujevac Faculty of Philology and Arts Department of German Language and Literature, T. Vujošević Anđela
Published: March 2022

This paper analyses lexical means for the NATO bombing of Yugoslavia in the German and Serbian press in 1999. The theoretical part describes the model of the three-dimensional meaning of Fritz Hermanns, according to which the functions of the linguistic sign can be realised on three levels: cognitive, emotional and deontic. The lexical means for the NATO bombing are first analysed in the empirical part, which were found in 68 thematically relevant articles in the Serbian weekly magazine NIN and in 39 articles in the German magazine SPIGEL during the NATO aggression on FRY from March to June 1999. The results have been also shown quantitatively. An important part of the work is the socio-political context of the selected event, which contributes to the semantic analysis of the found lexical means that have certain semantic meaning within the given discourse. As a starting point of the paper we used Humboldt's thesis, that linguistic diversity actually makes a diﬀerence in the world view, so the paper tries to answer the question of how language and selected lexicon form the opinion of an individual or a social group about an event, and how the conﬂict between political and military forces is presented in two diﬀerent languages and so reﬂected in the languages further inﬂuences the speakers of these languages.
RITRATTO DI UN GENIO POLIEDRICO: GIOSUE CARDUCCI VISTO DA MARKO CAR
Authors:   Università di Banja Luka Facoltà di Filologia, Ž. Kovačević Zorana
Published: March 2022

Lo scopo di questo lavoro è presentare lo studio di Marko Car Giosuè Carducci. Italijanski pjesnik. Biografčno-kritična crtica (Giosuè Carducci. Poeta italiano. Schizzo biografco-critico, 1884), pensato come un omaggio al poeta italiano, ma soprattutto come tentativo di suscitare nei suoi connazionali l’interesse per la vita e l’opera di Carducci. Dopo alcune considerazioni preliminari riguardanti la notevole presenza dell’Italia nella vita e nell’opera di Marko Car, si cercherà di illustrare in che modo Car restituisce ai suoi lettori l’immagine di Carducci, prestando attenzione alle fonti critiche che conﬂuiscono nella stesura del testo, nonché alle afnità che Car riconosce tra se stesso e Carducci.
THE COMMUNITY OF FOXES
Authors:   Nanjing University, Xu Xingwu
Published: March 2022

Liao Zhai zhi yi (Strange Stories from a Lonely Studio) and Yue Wei Cao Tang Bi Ji (The Notes of Yuewei Cottage), two renown Classical Chinese novels of the Qing Dynasty, contain many stories about foxes. The former contains more than 70 such stories and the latter contains more than 130. Foxes in these stories vary greatly in terms of their types. More importantly, a noticeable phenomenon in these stories is that, just like human beings, foxes’ dwellings can be identified as rural and urban, domestic and wild. In other words, foxes from different communities bear overt differences concerning their characters and behaviors. For example, Liao Zhai zhi yi is skilled in delineating rural foxes with pastoral temperament, who frequently escalate their emotion and lust. On the other hand, Yue Wei Cao Tang Bi Ji is adept in rendering urban foxes with intellectual men, who often show their nurturing and wisdom. And this phenomenon reveals the differing life experience, social statuses and cultural visions of the two authors. Concomitantly, it also betrays the different folklore sources utilized by the two authors.
COMPARATIVE STUDY OF THE ILLUSTRATIONS OF THE NOVEL INVESTITURE OF THE GODS BASED ON WOODBLOCK EDITIONS AND POPULAR PRINTS NIANHUA
Authors:   Institute of Oriental Studies of the RAS, Zavidovskaia Ekaterina ,   Bryansk State University, Maiatskii Dmitrii ,   St. Petersburg State University
Published: March 2022

The authors of this paper discuss visual material based on the plot of the Ming dynasty novel Investiture of the Gods (Fengshen yanyi, 封神演義), formed on the basis of large corpus of written historical works and Song-Yuan vernacular literature. Various illustrated woodblock and lithographic editions of the novel (published before 1911) are discussed in chronological order with focus on the special features and artistic level of their illustrations, whose content and technique are compared. Popular woodblock prints nianhua from Russian collections are examined in order to trace whether connections with book illustrations exist and what episodes of the novel became more popular and for what reason. The paper refers to materials stored in prominent libraries, museums and research centers of Russia, Europe, US and Asia.
CURRENT PROBLEMS IN THE STUDY OF CONFUCIAN CLASSICS (BASED ON THE TEXT OF LI JI)
Authors:   Amur State University, Keidun Irina
Published: March 2022

The article attempts to analyze the canonical Confucian treatise Li Ji from the philosophical and religious studies’ perspective. Utilizing the information contained in the text, this article reconstructs the content of the ancient Chinese rituals of the life cycle — initiation, marriage, funeral and mourning, all of which served to trace and formalize changes in a person’s social status, securing his transition to a new position. Structure, functions and symbolism of ancient Chinese transitional ceremonies generally correspond with the theory of rituals of passage developed by the French researcher A. van Gennep. The results of this work demonstrate that the treatise may in the future become the object of close attention of researchers from various scientific branches, analyzing the panhuman universals of spiritual development.
CATEGORY OF 混 (HÙN, “PRIMORDIAL CHAOS”) IN FOUR GREAT CLASSICAL NOVELS
Authors:   Belarusian State University, Klimovich Victoria
Published: March 2022

混 (hùn, “primordial chaos”) is one of the most complex and multi-aspect concepts in Chinese philosophy. This category was fully developed in the Taoist texts, dating back to the 4th–3th centuries BC. Taoist philosophers interpreted the concept not just as the core of cosmogony, but also as the basis of all ethical and socio-political concepts. In Taoist texts all the meanings are distinctly positive and opposed to the concept of 乱 (luàn, “disorder”), which means destruction of the original chaotic (i. e., holistic) nature of the universe. To determine how this concept transpire in traditional Chinese culture and to what extent it is still considered to be positive, the author analyzed the usage of the word in the four great classical novels: Water Margin, Romance of the Three Kingdoms, Journey to the West and Dream of the Red Chamber.