bluuebunny/crossref_metadata_2025 huggingface dataset:
The Relationship between Mental and Physical Minor Health Complaints and the Intake of Dietary Nutrients
Authors: Kagami-Katsuyama Hiroyo , Sato-Ueshima Maremi , Satoh Kouji , Tousen Yuko , Takimoto Hidemi , Maeda-Yamamoto Mari , Nishihira Jun
Published: February 2023

Presenteeism is a problem that needs to be solved urgently, both for individual workers and for society overall. In this report, we propose the concept of MHC, which refers to mild mental and physical complaints subjectively perceived by individuals that are not caused by illness. We also planned to examine what kind of physical and mental disorder MHC is and whether food is effective as a method of self-care for MHC. First, we conducted “the comprehensive survey to establish an integrated database of food, gut microbiome, and health information” (the “Sukoyaka Health Survey”) and obtained data on psychosomatic disorders and intakes of dietary nutrients. As a result, through factor analysis and item response theory analysis, we found the following specific examples of MHC: lack of vigor, irritability, fatigue, and somatic complaints. In addition, analysis of the relationship between these four MHC levels and the intake dietary nutrients indicated that they are closely related and that MHC levels can be improved by consuming sufficient amounts of multiple nutrients.
Do Urban Hedgehogs (Erinaceus europaeus) Represent a Relevant Source of Zoonotic Diseases?
Authors: Jota Baptista Catarina , Oliveira Paula A. , Gonzalo-Orden José M. , Seixas Fernanda
Published: February 2023

Urban fauna is defined as animal species that can live in urban environments. Several species, including the western-European hedgehog (Erinaceus europaeus), have now been identified as part of this urban fauna, becoming permanent residents of parks and gardens in different cities across Europe. Due to the importance that this phenomenon represents for zoonotic disease surveillance, several authors have been conducting zoonotic agents’ surveys on hedgehog. The aim of this study is to compare zoonotic diseases’ prevalence in hedgehogs in urban environments with those from more rural areas. A systematic review with meta-analysis of twelve studied of zoonotic diseases’ (in urban and rural areas of Europe) was therefore conducted for this purpose. Fifteen different zoonoses have been assessed in urban environments and six in rural areas. Anaplasma phagocytophilum was the most prevalent zoonotic agent found in urban habitats (96%). Dermatophytosis shows statistically significant differences between locations (p-value < 0.001), with a higher prevalence in urban Poland (55%; n = 182). Our results suggest further research and a standardized monitoring of different hedgehog populations are essential to understanding the epidemiology of several zoonotic pathogens in different habitat types (urban, rural, natural, industrial, etc.) and preventing possible disease outbreaks.
Potential of Mesenchymal Stromal Cell-Derived Extracellular Vesicles as Natural Nanocarriers: Concise Review
Authors: Draguet Florian , Bouland Cyril , Dubois Nathan , Bron Dominique , Meuleman Nathalie , Stamatopoulos Basile , Lagneaux Laurence
Published: February 2023

Intercellular communication, through direct and indirect cell contact, is mandatory in multicellular organisms. These last years, the microenvironment, and in particular, transfer by extracellular vesicles (EVs), has emerged as a new communication mechanism. Different biological fluids and cell types are common sources of EVs. EVs play different roles, acting as signalosomes, biomarkers, and therapeutic agents. As therapeutic agents, MSC-derived EVs display numerous advantages: they are biocompatible, non-immunogenic, and stable in circulation, and they are able to cross biological barriers. Furthermore, EVs have a great potential for drug delivery. Different EV isolation protocols and loading methods have been tested and compared. Published and ongoing clinical trials, and numerous preclinical studies indicate that EVs are safe and well tolerated. Moreover, the latest studies suggest their applications as nanocarriers. The current review will describe the potential for MSC-derived EVs as drug delivery systems (DDS) in disease treatment, and their advantages. Thereafter, we will outline the different EV isolation methods and loading techniques, and analyze relevant preclinical studies. Finally, we will describe ongoing and published clinical studies. These elements will outline the benefits of MSC-derived EV DDS over several aspects.
Antimicrobial Preservatives for Protein and Peptide Formulations: An Overview
Authors: Stroppel Luisa , Schultz-Fademrecht Torsten , Cebulla Martin , Blech Michaela , Marhöfer Richard J. , Selzer Paul M. , Garidel Patrick
Published: February 2023

Biological drugs intended for multi-dose application require the presence of antimicrobial preservatives to avoid microbial growth. As the presence of certain preservatives has been reported to increase protein and peptide particle formation, it is essential to choose a preservative compatible with the active pharmaceutical ingredient in addition to its preservation function. Thus, this review describes the current status of the use of antimicrobial preservatives in biologic formulations considering (i) appropriate preservatives for protein and peptide formulations, (ii) their physico-chemical properties, (iii) their in-/compatibilities with other excipients or packaging material, and (iv) their interactions with the biological compound. Further, (v) we present an overview of licensed protein and peptide formulations.
Targeting Interleukin 13 for the Treatment of Atopic Dermatitis
Authors: Lytvyn Yuliya , Gooderham Melinda
Published: February 2023

Atopic dermatitis (AD) is a common chronic inflammatory skin condition that has a significant impact on a patient’s quality of life and requires ongoing management. Conventional topical and systemic therapies do not target specific components of AD pathogenesis and, therefore, have limited efficacy and may be associated with long-term toxicity. Thus, AD management is challenging, with a significant proportion of patients not achieving clear skin or a reduction in pruritus. There remains a large unmet need for effective therapeutic strategies with favorable safety profiles that can be used long-term in patients with refractory AD. The emergence of targeted biological and small molecule therapies has effectively broadened available treatment options for moderate-to-severe AD. Most recently, interleukin 13 (IL-13) inhibitors were shown to be efficacious and well-tolerated, with tralokinumab already approved for use in this patient population. It is important for dermatologists to be aware of the evidence behind this emerging class of biologic agents to guide treatment choices and improve outcomes in patients with AD. The main objective of this paper is to review the current literature regarding the efficacy and safety of current and emerging anti-IL-13 monoclonal antibodies, including tralokinumab, lebrikizumab, cendakimab, and eblasakimab, for the treatment of moderate-to-severe AD.
The Mitochondrion: A Promising Target for Kidney Disease
Authors: Tanriover Cem , Copur Sidar , Ucku Duygu , Cakir Ahmet B. , Hasbal Nuri B. , Soler Maria Jose , Kanbay Mehmet
Published: February 2023

Mitochondrial dysfunction is important in the pathogenesis of various kidney diseases and the mitochondria potentially serve as therapeutic targets necessitating further investigation. Alterations in mitochondrial biogenesis, imbalance between fusion and fission processes leading to mitochondrial fragmentation, oxidative stress, release of cytochrome c and mitochondrial DNA resulting in apoptosis, mitophagy, and defects in energy metabolism are the key pathophysiological mechanisms underlying the role of mitochondrial dysfunction in kidney diseases. Currently, various strategies target the mitochondria to improve kidney function and kidney treatment. The agents used in these strategies can be classified as biogenesis activators, fission inhibitors, antioxidants, mPTP inhibitors, and agents which enhance mitophagy and cardiolipin-protective drugs. Several glucose-lowering drugs, such as glucagon-like peptide-1 receptor agonists (GLP-1-RA) and sodium glucose co-transporter-2 (SGLT-2) inhibitors are also known to have influences on these mechanisms. In this review, we delineate the role of mitochondrial dysfunction in kidney disease, the current mitochondria-targeting treatment options affecting the kidneys and the future role of mitochondria in kidney pathology.
Cyclosporine A-Loaded Ternary Solid Dispersion Prepared with Fine Droplet Drying Process for Improvement of Storage Stability and Oral Bioavailability
Authors: Moritani Tatsuru , Usui Hayato , Morinaga Tadahiko , Sato Hideyuki , Onoue Satomi
Published: February 2023

This study aimed to develop a cyclosporine A (CsA)-loaded ternary solid dispersion (tSD/CsA) to improve the storage stability of a solid dispersion (SD) system and the oral absorbability of CsA. Hydroxypropyl cellulose (HPC) and hydroxypropyl methylcellulose acetate succinate (HPMCAS) were selected as carrier materials of tSD, and tSD/CsA was prepared with a fine droplet drying process, a powderization technology that employs an inkjet head. The physicochemical properties of tSD/CsA were evaluated in terms of morphology, storage stability, dissolution behavior, and mucoadhesive property. After the oral administration of CsA samples (10 mg-CsA/kg) to rats, the plasma concentration of CsA was monitored to estimate oral absorbability. tSD/CsA comprised uniform shriveled particles with a diameter of 3.4 mm and span factor of 0.4, which is a parameter to estimate the particle size distribution. Although HPC-based binary SD showed marked aggregation of the particles after storage under 40 °C/75% relative humidity, there were no significant aggregations of tSD/CsA, due to the relatively low hygroscopic property of HPMCAS. The pH-dependent release of CsA with improved dissolution was observed in tSD/CsA. In the in vitro mucoadhesive evaluation using a mucin disk, tSD/CsA exhibited a better mucoadhesive property than HPC-based SD, possibly leading to prolonged retention of tSD particles in the gastrointestinal tract after oral administration. Orally-dosed tSD/CsA in rats resulted in significantly improved oral absorption of CsA, as evidenced by a 27-fold higher bioavailability than amorphous CsA. tSD/CsA may be a promising dosage option to improve the storage stability of a SD system and the biopharmaceutical properties of CsA.
Overview of Addressed Fiber Bragg Structures’ Development
Authors: Agliullin Timur , Il’In German , Kuznetsov Artem , Misbakhov Rinat , Misbakhov Rustam , Morozov Gennady , Morozov Oleg , Nureev Ilnur , Sakhabutdinov Airat
Published: February 2023

An addressed fiber Bragg structure (AFBS) is a special type of fiber Bragg grating simultaneously performing the functions of a two-frequency radiation shaper and a sensitive element. An AFBS forms a two-frequency optical spectral response at its output, the difference frequency of which is invariant to measured physical fields and is referred to as the address frequency of the AFBS. Each of the AFBSs in the system has its own address frequency; therefore, a number of such structures can be interrogated simultaneously enabling the addressed multiplexing. In this article, we provide an overview of the theory and technology of AFBS, including the structures with three or more spectral components with various combinations of difference frequencies, both symmetrical and asymmetric. The subjects of interrogation of AFBSs, their fabrication and calibration are discussed as well. We also consider a wide range of applications in which AFBS can be used, covering such areas as oil and gas production, power engineering, transport, medicine, etc. In addition, the prospects for the further development of AFBS are proposed that mitigate the shortcomings of the current AFBSs’ state of the art and open up new possibilities of their application.
Digging Deeper through Biological Specimens Using Adaptive Optics-Based Optical Microscopy
Authors: Raju Gagan , Mazumder Nirmal
Published: February 2023

Optical microscopy is a vital tool for visualizing the cellular and sub-cellular structures of biological specimens. However, due to its limited penetration depth, its biological applicability has been hindered. The scattering and absorption of light by a wide array of biomolecules causes signal attenuation and restricted imaging depth in tissues. Researchers have put forth various approaches to address this, including designing novel probes for imaging applications and introducing adaptive optics (AO) technology. Various techniques, such as direct wavefront sensing to quickly detect and fix wavefront deformation and indirect wavefront sensing using modal and zonal methods to rectify complex aberrations, have been developed through AO paradigms. In addition, algorithmic post-processing without mechanical feedback has been utilized to correct the optical patterns using the matrix-based method. Hence, reliable optical imaging through thick biological tissue is made possible by sensorless AO. This review highlights the latest advancements in various AO-based optical microscopy techniques for depth-resolved imaging and briefly discusses their potential in various biomedical applications.
Liquid-Crystal Spin-VCSEL with Electro-Optically Controllable Birefringence
Authors: Panajotov Krassimir , Petrov Minko , Marinov Yordan
Published: February 2023

We suggest a new construction of spin-VCSEL with an embedded nematic liquid crystal (LC) in a second cavity. We design such a coupled-cavity LC-VCSEL and develop a procedure for calculating its LC-voltage dependent polarization resolved resonant longitudinal modes and their quantum-well confinement factors. Using these characteristics, we are able to slightly modify the spin-flip VCSEL model to include the voltage dependent birefringence and anisotropy. Then, we show that such an LC-VCSEL can reach small signal modulation response with a 3dB cut off frequency of several hundreds of GHz.
Morphological, Phylogenetic and Toxinological Characterization of Potentially Harmful Algal Species from the Marine Coastal Waters of Buenos Aires Province (Argentina)
Authors: Tardivo Kubis Jonás Adrián , Rodríguez Francisco , Rossignoli Araceli E. , Riobó Pilar , Sar Eugenia A. , Sunesen Inés
Published: February 2023

In the framework of a monitoring program of harmful microalgae from the marine coastal waters of the Buenos Aires Province, seven strains were isolated and characterized by morphological and molecular analysis (LSU rDNA partial sequencing, D1–D3 regions). Established strains belonged to Alexandrium catenella, Protoceratium reticulatum and Pseudo-nitzschia multiseries. The toxinological profile of the target strains were determined by UHPLC-FLD equipment for paralytic shellfish toxins (PSTs) and LC-MS/MS for lipophilic (LSTs) and amnesic toxins (ASTs). The toxin profile varied in the four strains of A. catenella, the predominant compounds were gonyautoxins (GTXs) GTX2,3 and GTX1,4 for strains LPCc001 and LPCc004, and N-sulfocarbamoyl toxins (Cs) C1,2 and GTX1,4 for strains LPCc002 and LPCc008. The obtained cellular toxicity values were moderate-to-high (12.38–46.40 pg saxitoxin equiv. cell−1). The toxin profile of P. reticulatum was dominated by yessotoxins (YTXs) (up to 94.40 pg cell−1) accompanied by homo-yessotoxin (Homo-YTX) traces. In P. multiseries, the toxin profiles were dominated by domoic acid (DA) (1.62 pg cell−1 and 1.09 pg cell−1) and secondarily by Isomer A (Iso-A), Epi-domoic acid (Epi-DA), Isomer-E (Iso-E) and Isomer-D (Iso-D). This study provides detailed information about representative HAB species in the area, useful for resource management, risk evaluation and related research on toxic dinoflagellates and diatoms.
Physical Mechanisms Underpinning the Vacuum Permittivity
Authors: Leuchs Gerd , Hawton Margaret , Sánchez-Soto Luis L.
Published: February 2023

The debate about the emptiness of space goes back to the prehistory of science and is epitomized by the Aristotelian ‘horror vacui’, which can be seen as the precursor of the ether, whose modern version is the dynamical quantum vacuum. In this paper, we suggest to change a common view to ‘gaudium vacui’ and discuss how the vacuum fluctuations fix the value of the permittivity, ε0, and permeability, μ0, by modelling their dynamical response by three-dimensional harmonic oscillators.
Effects of Soil Nutrients on Plant Nutrient Traits in Natural Pinus tabuliformis Forests
Authors: Gao Jie , Wang Jiangfeng , Li Yanhong
Published: February 2023

In light of global warming, the interaction between plant nutrient traits and soil nutrients is still unclear. Plant nutrient traits (e.g., N and P) and their stoichiometric relationships (N/P ratio) are essential for plant growth and reproduction. However, the specific role of soil nutrients in driving variation in plant nutrient traits remains poorly understood. Fifty natural Pinus tabuliformis forests were used as the research object to clarify the interaction between plant nutrient traits and soil nutrients. We show that: (1) The Nmass, Pmass and N/P ratios of leaves were significantly higher than those of roots. The N/P ratio of both leaves and roots was less than 14. (2) Leaf nutrient traits showed diverse relationship patterns with root nutrient traits throughout the growing period. Significant changes were found in root nutrient PC2 (the second principal component of root nutrient traits) and leaf nutrient PC1 (the first principal component of leaf traits), and non-significant changes were found in other relationships between leaf and root traits (p > 0.05). Root nutrient traits explained 36.4% of the variance in leaf nutrient traits. (3) With the increase in soil nutrient PC2 (related to N), leaf PC2 (related to N) showed a significant trend of first decreasing and then increasing (p < 0.05). Only the soil Nmass was significantly correlated with the leaf Nmass (p < 0.05), which demonstrated that the growth and survival of Pinus tabuliformis forests were mainly affected by N-limitation.
Exploiting Rye in Wheat Quality Breeding: The Case of Arabinoxylan Content
Authors: Piro Maria Chiara , Muylle Hilde , Haesaert Geert
Published: February 2023

Rye (Secale cereale subsp. cereale L.) has long been exploited as a valuable alternative genetic resource in wheat (Triticum aestivum L.) breeding. Indeed, the introgression of rye genetic material led to significant breakthroughs in the improvement of disease and pest resistance of wheat, as well as a few agronomic traits. While such traits remain a high priority in cereal breeding, nutritional aspects of grain crops are coming under the spotlight as consumers become more conscious about their dietary choices and the food industry strives to offer food options that meet their demands. To address this new challenge, wheat breeding can once again turn to rye to look for additional genetic variation. A nutritional aspect that can potentially greatly benefit from the introgression of rye genetic material is the dietary fibre content of flour. In fact, rye is richer in dietary fibre than wheat, especially in terms of arabinoxylan content. Arabinoxylan is a major dietary fibre component in wheat and rye endosperm flours, and it is associated with a variety of health benefits, including normalisation of glycaemic levels and promotion of the gut microbiota. Thus, it is a valuable addition to the human diet, and it can represent a novel target for wheat–rye introgression breeding.
Phytotoxic Effects of Polystyrene and Polymethyl Methacrylate Microplastics on Allium cepa Roots
Authors: Biba Renata , Cvjetko Petra , Jakopčić Mihaela , Komazec Bruno , Tkalec Mirta , Dimitrov Nino , Begović Tajana , Balen Biljana
Published: February 2023

Plastic contamination has become one of the most pressing environmental issues due to rapidly increasing production of disposable plastic products, their fragmentation into smaller pieces, and long persistence in the environment, which affects all living organisms, including plants. In this study, Allium cepa roots were exposed to 0.01, 0.1, and 1 g L−1 of commercial polystyrene (PS-MPs) and polymethyl methacrylate microparticles (PMMA-MPs) for 72 h. Dynamic light scattering (DLS) analyses showed high stability of both types of MPs in ultrapure water used for A. cepa treatment. Morphometric analysis revealed no significant change in root length compared to control. Pyrolysis hyphenated to gas chromatography and mass spectrometry (Py-GC-MS) has proven PS-MPs uptake by onion roots in all treatments, while PMMA-MPs were recorded only upon exposure to the highest concentration. Neither MPs induced any (cyto)toxic effect on root growth and PMMA-MPs even had a stimulating effect on root growth. ROS production as well as lipid and protein oxidation were somewhat higher in PS-MP treatments compared to the corresponding concentrations of PMMA-MP, while neither of the applied MPs induced significant damage to the DNA molecule assayed with a Comet test. Significantly elevated activity of H2O2 scavenging enzymes, catalase, and peroxidases was measured after exposure to both types of MPs. Obtained results suggest that onion roots take up PS-MPs more readily in comparison to PMMA-MPs, while both types of MPs induce a successful activation of antioxidant machinery in root cells that prevented the occurrence of toxic effects.
Customized Technological Designs to Improve the Traditional Use of Rosa canina Fruits in Foods and Ingredients
Authors: Teodorescu Adina Andreea , Milea Ștefania Adelina , Păcularu-Burada Bogdan , Nistor Oana Viorela , Andronoiu Doina Georgeta , Râpeanu Gabriela , Stănciuc Nicoleta
Published: February 2023

The rosehip fruits from Romanian spontaneous flora were valorized in three different customized variants, including jellified products, juices, and a nutraceutical. Prior to the technological design, the rosehip samples were characterized for individual polyphenolic content. The samples (non)-enzymatically treated showed epicatechin as the major compound, whereas the enzymatic treatment enhanced the extraction of quercetin (40.23 ± 0.48 mg/100 g DW extract), gallic acid (9.74 ± 0.24 mg/100 g DW extract), and kaempferol. Different ratios and types of sugars were added to obtain jellified products, leading to a significantly different bioactive profile. The sugar-free and steviol samples showed the highest content in carotenoids (89.36 ± 0.06 mg/g dry weight (DW) and 39.22 ± 1.16 mg/g DW, respectively), leading to the highest antioxidant activity (8.19 ± 0.80 mMol Trolox/g DW and 20.16 ± 0.31 mMol Trolox/g DW, respectively). The gelling capacity increased with the increase in sugar content. The enzymatically treated rosehip fruit pulp was mixed in various ratios with apple juice, followed by pasteurization. The polyphenolic content was approximately two times higher in the blended juices (20.75 ± 1.40 mg gallic acid equivalents (GAE)/100 mL). The overall impression highlighted the preferences of panelists for sugar-free products, whereas adding apple juice significantly influenced their preferences. The fresh pulp was enhanced with pectin, followed by inoculation with Lactobacillus acidophilus, and freeze-dried showed satisfactory cell viability (approximately 7 log CFU/g DW), whereas an antidiabetic, anti-tyrosinase and anti-obesity potential of the powder was suggested. Our results provide enough evidence for customized processing of rosehip fruits in foods and nutraceuticals as a response to consumers’ choices, highlighting the bioactive compounds and nutrient contents, whereas selected in vitro health-related evidence was suggested.
Is the Phytotoxic Effect of Digestive Fluid of Nepenthes x ventrata on Tomato Related to Reactive Oxygen Species?
Authors: Staszek Pawel , Piekarniak Maciej , Wal Agnieszka , Krasuska Urszula , Gniazdowska Agnieszka
Published: February 2023

The digestive fluid of pitcher plants is a rich source of enzymes and secondary metabolites, but its impact on higher plant growth and development remains unknown. The aim of the study was to determine the phytotoxicity of the digestive fluid of the pitcher plant (Nepenthes x ventrata) on the germination of tomato (Solanum lycopersicum L.) seeds, elongation growth and cell viability of roots of tomato seedlings. The digestive fluid was collected from pitchers before feeding and four days after feeding; the pH and electrical conductivity of the fluid were determined. Undiluted and 50% fluids were used in the study. An inhibition of germination of tomato seeds, by around 30% and 55%, was respectively observed in 50% and 100% digestive fluids collected before and after feeding. Digestive fluid did not affect the root growth of tomato seedlings; a slight (6%) inhibition was only observed after the application of 100% digestive fluid from an unfed trap. The roots of the tomato seedlings treated with undiluted fluid were characterized by reduced cell viability. Reactive oxygen species (H2O2 and O2•−) were mainly localized in the root apex regardless of the used phytotoxic cocktail, and did not differ in comparison to control plants.
Evaluation of Selenium Nanoparticles in Inducing Disease Resistance against Spot Blotch Disease and Promoting Growth in Wheat under Biotic Stress
Authors: Shahbaz Muhammad , Akram Abida , Mehak Asma , Haq Ehsan ul , Fatima Noor , Wareen Gull , Fitriatin Betty Natalie , Sayyed R. Z. , Ilyas Noshin , Sabullah Mohd Khalizan
Published: February 2023

In the present study, SeNPs were synthesized using Melia azedarach leaf extracts and investigated for growth promotion in wheat under the biotic stress of spot blotch disease. The phytosynthesized SeNPs were characterized using UV-visible spectroscopy, scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), and Fourier-transformed infrared spectroscopy (FTIR). The in vitro efficacy of different concentrations of phytosynthesized SeNPs (i.e., 100 μg/mL, 150 μg/mL, 200 μg/mL, 250 μg/mL, and 300 μg/mL) was evaluated using the well diffusion method, which reported that 300 μg/mL showed maximum fungus growth inhibition. For in vivo study, different concentrations (10, 20, 30, and 40 mg/L) of SeNPs were applied exogenously to evaluate the morphological, physiological, and biochemical parameters under control conditions and determine when infection was induced. Among all treatments, 30 mg/L of SeNPs performed well and increased the plant height by 2.34% compared to the control and 30.7% more than fungus-inoculated wheat. Similarly, fresh plant weight and dry weight increased by 17.35% and 13.43% over the control and 20.34% and 52.48% over the fungus-treated wheat, respectively. In leaf surface area and root length, our findings were 50.11% and 10.37% higher than the control and 40% and 71% higher than diseased wheat, respectively. Plant physiological parameters i.e., chlorophyll a, chlorophyll b, and total chlorophyll content, were increased 14, 133, and 16.1 times over the control and 157, 253, and 42 times over the pathogen-inoculated wheat, respectively. Our findings regarding carotenoid content, relative water content, and the membrane stability index were 29-, 49-, and 81-fold higher than the control and 187-, 63-, and 48-fold higher than the negative control, respectively. In the case of plant biochemical parameters, proline, sugar, flavonoids, and phenolic contents were recorded at 6, 287, 11, and 34 times higher than the control and 32, 107, 33, and 4 times more than fungus-inoculated wheat, respectively. This study is considered the first biocompatible approach to evaluate the potential of green-synthesized SeNPs as growth-promoting substances in wheat under the spot blotch stress and effective management strategy to inhibit fungal growth.
Design Rules of Bidirectional Smart Sensor Coating for Condition Monitoring of Bearings
Authors: Nguyen Van-Cuong , Le Minh-Quyen , Bernadet Sophie , Hebrard Yoann , Mogniotte Jean-François , Capsal Jean-Fabien , Cottinet Pierre-Jean
Published: February 2023

This paper reports a novel monitoring technique of bearings’ bidirectional load (axial and radial) based on a smart sensor coating, which is screen printed onto the surface of a cross-shaped steel substrate. To ensure the accuracy and stability of measurement as well as the durability of the printed coating, the developed prototype is built according to design rules commonly used in electronic circuits. The finite element model (FEM) is used to predict the mechanical property of the tested substrate under either unidirectional or bidirectional loads. Regarding the output voltage of the piezoelectric sensor, experimental results are revealed to be well-corelated to the numerical simulation. It is pointed out that the output signal generated from the sensor (electrode) could be particularly affected due to the capacitive parasite coming from the conductive tracks (CTs). Such a phenomenon might be reduced by printing them on the dielectric layer rather than on the piezocomposite layer. The study also investigates a highly anisotropic shape of electrodes (rectangular instead of circle), indicating that the orientation of such electrodes (axial or radial) does affect the output measurement. To sum up, the high performance of a sensor network coating depends not only on the ultimate characteristics of its own materials, but also on its structural design. Such an issue has been rarely reported on in the literature, but is nonetheless crucial to achieving reliable condition monitoring of bearings, especially for multidirectional loads—a key signature of early failure detection.
Assessing Mechanical Properties of Jute, Kenaf, and Pineapple Leaf Fiber-Reinforced Polypropylene Composites: Experiment and Modelling
Authors: Sayeed M. M. Alamgir , Sayem Abu Sadat Muhammad , Haider Julfikar , Akter Sharmin , Habib Md. Mahmudul , Rahman Habibur , Shahinur Sweety
Published: February 2023

The application of natural fibers is increasing rapidly in the polymer-based composites. This study investigates manufacturing and characterization of polypropylene (PP) based composites reinforced with three different natural fibers: jute, kenaf, and pineapple leaf fiber (PALF). In each case, the fiber weight percentages were varied by 30 wt.%, 35 wt.%, and 40 wt.%. Mechanical properties such as tensile, flexural, and impact strengths were determined by following the relevant standards. Fourier transform infrared (FTIR) spectroscopy was employed to identify the chemical interactions between the fiber and the PP matrix material. Tensile strength and Izod impact strength of the composites significantly increased for all the composites with different fiber contents when compared to the pure PP matrix. The tensile moduli of the composites were compared to the values obtained from two theoretical models based on the modified “rule of mixtures” method. Results from the modelling agreed well with the experimental results. Tensile strength (ranging from 43 to 58 MPa), flexural strength (ranging from 53 to 67 MPa), and impact strength (ranging from 25 to 46 kJ/m2) of the composites significantly increased for all the composites with different fiber contents when compared to the pure PP matrix having tensile strength of 36 MPa, flexural strength of 53 Mpa, and impact strength of 22 kJ/m2. Furthermore, an improvement in flexural strength but not highly significant was found for majority of the composites. Overall, PALF-PP displayed better mechanical properties among the composites due to the high tensile strength of PALF. In most of the cases, T98 (degradation temperature at 98% weight loss) of the composite samples was higher (532–544 °C) than that of 100% PP (500 °C) matrix. Fractured surfaces of the composites were observed in a scanning electron microscope (SEM) and analyses were made in terms of fiber matrix interaction. This comparison will help the researcher to select any of the natural fiber for fiber-based reinforced composites according to the requirement of the final product.
Influence of the Chemical Structure on the Mechanical Relaxation of Dendrimers
Authors: Sheveleva Nadezhda N. , Komolkin Andrei V. , Markelov Denis A.
Published: February 2023

The rheological properties of macromolecules represent one of the fundamental features of polymer systems which expand the possibilities of using and developing new materials based on them. In this work, we studied the shear-stress relaxation of the second generation PAMAM and PPI dendrimer melts by atomistic molecular dynamics simulation. The time dependences of relaxation modulus G(t) and the frequency dependences of the storage G′(ω) and loss G″(ω) moduli were obtained. The results were compared with the similar dependences for the polycarbosilane (PCS) dendrimer of the same generation. The chemical structure of the dendrimer segments has been found to strongly influence their mechanical relaxation. In particular, it has been shown that hydrogen bonding in PAMAM dendrimers leads to an entanglement of macromolecules and the region is observed where G′(ω) > G″(ω). This slows down the mechanical relaxation and rotational diffusion of macromolecules. We believe that our comprehensive research contributes to the systematization of knowledge about the rheological properties of dendrimers.
Recent Progress in Proteins-Based Micelles as Drug Delivery Carriers
Authors: Mustafai Aleena , Zubair Muhammad , Hussain Ajaz , Ullah Aman
Published: February 2023

Proteins-derived polymeric micelles have gained attention and revolutionized the biomedical field. Proteins are considered a favorable choice for developing micelles because of their biocompatibility, harmlessness, greater blood circulation and solubilization of poorly soluble drugs. They exhibit great potential in drug delivery systems as capable of controlled loading, distribution and function of loaded agents to the targeted sites within the body. Protein micelles successfully cross biological barriers and can be incorporated into various formulation designs employed in biomedical applications. This review emphasizes the recent advances of protein-based polymeric micelles for drug delivery to targeted sites of various diseases. Most studied protein-based micelles such as soy, gelatin, casein and collagen are discussed in detail, and their applications are highlighted. Finally, the future perspectives and forthcoming challenges for protein-based polymeric micelles have been reviewed with anticipated further advances.
Nanocellulose-Based Biomaterial Ink Hydrogel for Uptake/Release of Bovine Serum Albumin
Authors: Wan Jusoh Wan Nazihah Liyana , Mohan Denesh , Sajab Mohd Shaiful , Abdul Peer Mohamed , Kaco Hatika , Ding Gongtao , Baini Rubiyah
Published: February 2023

This study explores the potential of using nanocellulose extracted from oil palm empty fruit bunch (OPEFB) as a biomaterial ink for 3D printing. The research focuses on using nanocellulose hydrogels for the controlled uptake and release of proteins, with the specific protein solution being Bovine Serum Albumin (BSA). To provide a suitable material for the bioprinting process, the study examines the characteristics and properties of the printed hydrogels through various analyses, such as morphology, functional group, crystallinity, and compression test. Several parameters, such as initial concentration, temperature, and the presence of calcium chloride as an additional crosslinker, affect the protein uptake and release capabilities of the hydrogel. The study is important for biomedicine as it explores the behavior of protein uptake and release using nanocellulose and 3D printing and can serve as a preliminary study for using hydrogels in biological materials or living cells.
Development of Hybrid Materials Based on Chitosan, Poly(Ethylene Glycol) and Laponite® RD: Effect of Clay Concentration
Authors: Morariu Simona , Brunchi Cristina-Eliza , Honciuc Mirela , Iftime Manuela-Maria
Published: February 2023

In the context of increasing interest in biomaterials with applicability in cosmetics and medicine, this research aims to obtain and characterize some hybrid materials based on chitosan (CS) (antibacterial, biocompatible, and biodegradable), poly(ethylene glycol) (PEG) (non-toxic and prevents the adsorption of protein and cell) and Laponite® RD (Lap) (bioactive). The rheological properties of the starting dispersions were investigated and discussed related to the interactions developed between components. All samples exhibited gel-like properties, and the storage modulus of CS/PEG dispersion increased from 6.6 Pa to 657.7 Pa by adding 2.5% Lap. Structural and morphological characterization of the films, prepared by solution casting method, was performed by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), and polarized light microscopy (POM). These analyses proved the incorporation of Lap into CS/PEG films and revealed the morphological changes of the films by the addition of clay. Thereby, at the highest Lap concentration (43.8%), the “house of cards” structure formed by Lap platelets, which incorporate chitosan chains, as evidenced by SEM and POM. Two stages of degradation between 200 °C and 410 °C were evidenced for the films with Lap concentration higher than 38.5%, explained by the existence of a clay-rich phase (given by the clay network) and chitosan-rich one (due to the intercalation of chitosan in the clay network). CS/PEG film with 43.8% Lap showed the highest swelling degree of 240.7%. The analysis of the obtained results led to the conclusion that the addition of clay to the CS/PEG films increases their stability in water and gives them greater thermal stability.
Physicochemical, Rheological, and Microstructural Properties of Low-Fat Mayonnaise Manufactured with Hydrocolloids from Dioscorea rotundata as a Fat Substitute
Authors: Rojas-Martin Leonardo , Quintana Somaris E. , García-Zapateiro Luis A.
Published: February 2023

(1) Background: In this study, the potential use of Dioscorea rotundata hydrocolloids was evaluated to develop low-fat mayonnaise. (2) Methods: The effect of different concentrations of hydrocolloids on the physicochemical, microstructural, and rheological properties of mayonnaise was evaluated. (3) Results: Physicochemical analyses showed pH values that were stable over time but decreased with increasing hydrocolloid concentration. The color parameters showed a decrease in luminosity and an increase in the values of a* and b* over time, which can be translated into an increase in yellow and a decrease in white, with a greater accentuation in the control sample. The rheological study allowed us to obtain a non-Newtonian flow behavior of the shear-thinning type for all samples, and the flow curves were well-fitted by the Sisko model (R2 ≥ 0.99). The samples had an elastic rather than viscous behavior, typical of dressings and emulsions. This indicates that the storage modulus was greater than the loss modulus (G′ > G″) in the evaluated frequency range. (4) Conclusions: hydrocolloids from Dioscorea rotundata have potential as a fat substitute in emulsion-type products.
An Improved Gradient-Based Optimization Algorithm for Solving Complex Optimization Problems
Authors: Altbawi Saleh Masoud Abdallah , Khalid Saifulnizam Bin Abdul , Mokhtar Ahmad Safawi Bin , Shareef Hussain , Husain Nusrat , Yahya Ashraf , Haider Syed Aqeel , Moin Lubna , Alsisi Rayan Hamza
Published: February 2023

In this paper, an improved gradient-based optimizer (IGBO) is proposed with the target of improving the performance and accuracy of the algorithm for solving complex optimization and engineering problems. The proposed IGBO has the added features of adjusting the best solution by adding inertia weight, fast convergence rate with modified parameters, as well as avoiding the local optima using a novel functional operator (G). These features make it feasible for solving the majority of the nonlinear optimization problems which is quite hard to achieve with the original version of GBO. The effectiveness and scalability of IGBO are evaluated using well-known benchmark functions. Moreover, the performance of the proposed algorithm is statistically analyzed using ANOVA analysis, and Holm–Bonferroni test. In addition, IGBO was assessed by solving well-known real-world problems. The results of benchmark functions show that the IGBO is very competitive, and superior compared to its competitors in finding the optimal solutions with high convergence and coverage. The results of the studied real optimization problems prove the superiority of the proposed algorithm in solving real optimization problems with difficult and indefinite search domains.
The Use of a Vortex Generator for the Efficient Cooling of Lithium-Ion Batteries in Hybrid Electric Vehicles
Authors: Bisht Ankit Singh , Bisht Vijay Singh , Bhandari Prabhakar , Rawat Kamal Singh , Alam Tabish , Blecich Paolo
Published: February 2023

High heat flux dissipation from the Lithium-ion battery pack of hybrid electric vehicles is one of the major concerns in the automotive sector, since it directly affects the performance and it may also lead to permanent failure. Among various thermal management systems, forced air cooling is most favorable due to its light weight, compactness, lower cost, and design flexibility. In the present work, a battery thermal management system with the two types of vortex generator in the coolant passage has been used to enhance the performance. A numerical model has been developed in commercial code to investigate the performance of the delta winglet and circular protrusion type vortex generator. Apart from that, both types of vortex generator have been compared in terms of various parameters such as pressure drop, weight, and maximum temperature. From the results of the simulation, it has been observed that both vortex generators performed better at the attack angle of 30° in comparison to the attack angles of 45° and 60°. Furthermore, it has also been found that the cooling system with protrusion as the vortex generator has performed better in terms of thermos-hydraulic performance compared to the cooling system with the delta winglet vortex generator. In addition to that, the protruded system is lighter in weight compared to both the plain and delta winglet systems, and is recommended.
Simulating Tablet Dissolution Using Computational Fluid Dynamics and Experimental Modeling
Authors: Liu Xinying , Zhong Chao , Fletcher David F. , Langrish Timothy A. G.
Published: February 2023

The study of mass transfer is essential in the food digestion process, especially when gastric acid interacts with food and nutrients dissolve in the gastric system. In this study, a computational fluid dynamics (CFD) model was built based on an in vitro study, which investigated the mass transfer in a tablet dissolution process in a beaker and stirrer system. The predicted mass transfer coefficients from the simulation aligned well with the experimental values. The effect of the type and rotation speed of the stirrers was also investigated. Mass transfer from the tablet was found to be closely related to the tablet Reynolds number of the fluid (ranging from 0 to 938) and the shear stress (0 to 0.167 Pa) acting on the tablet. The relationship between the power number (0.0061 to 0.196) and the Reynolds number for the impeller (719 to 5715) was also derived for different stirrers.
Research Progress on the Typical Variants of Simulated Moving Bed: From the Established Processes to the Advanced Technologies
Authors: Zhang Xiaotong , Liu Juming , Ray Ajay K. , Li Yan
Published: February 2023

Simulated moving bed (SMB) chromatography is a highly efficient adsorption-based separation technology with various industrial applications. At present, its application has been successfully extended to the biochemical and pharmaceutical industrial sectors. SMB possesses the advantages of high product purity and yield, large feed treatment capacity, and simple process control due to the continuous operation mode and the efficient separation mechanism, particularly for difficult separation. Moreover, SMB performs well, particularly for multi-component separation or complicated systems’ purification processes in which each component exhibits similar properties and low resolution. With the development of the economy and technology, SMB technology needs to be improved and optimized to enhance its performance and deal with more complex separation tasks. This paper summarizes the typical variants or modifications of the SMB process through three aspects: zone variant, gradient variant, and feed or operation variant. The corresponding modification principles, operating modes, advantages, limitations, and practical application areas of each variant were comprehensively investigated. Finally, the application prospect and development direction were summarized, which could provide valuable recommendations and guidance for future research in the SMB area.
Analysis and Test of Internal Blowing Anti-Tangle Bag-Breaking Device for Domestic Waste
Authors: Guo Mengyu , Hu Bin , Luo Xin
Published: February 2023

The mechanized resource utilization of domestic waste is the development trend in the field of waste treatment. The difficulty of bag breaking and the easy entanglement of domestic waste are the factors restricting the mechanization of waste separation and recycling. In response to the above problems, an internal blowing anti-tangle bag-breaking device for domestic waste was developed by combining the arc-type cutter and the internal flow field of the rotary. In addition, the motion trajectory of the cutters and the support rods were theoretically analyzed, as well as the force during the bag-breaking process of domestic waste. A three-factor, five-level orthogonal test was carried out to complete the regression ANOVA, and a relationship model was constructed between the test factors such as the cutting–support speed ratio, the center distance, the inlet flow rate and the response indicators such as the bag film length–perimeter ratio and bag film winding specific gravity. The key parameters and their significant interactions with the bag-breaking efficiency were analyzed to obtain the optimal combination of parameters for the device. Under the same conditions, the errors between the physical test and model predictions for the two response indicators were 5.46% and 7.90%, respectively, indicating that the verification test results were basically consistent with the model prediction results.
Leakage Characteristics of Proportional Directional Valve
Authors: Ledvoň Marian , Hružík Lumír , Bureček Adam , Dýrr Filip , Polášek Tomáš
Published: February 2023

This paper deals with the analysis of leakage characteristics of the proportional directional valve. These characteristics distinguish a real directional valve from an ideal one. The ideal directional valve is characterized by zero leakage due to its perfect geometry. The investigated element is the three-position four-way proportional directional valve with zero spool lap and feedback from the spool position. The spool position is measured by the inductive position sensor and processed by external electronics. Internal leakage occurs due to axial and radial clearances between the spool and the sleeve. The magnitude of axial clearances that occur at throttle edges and their effect on the directional valve leakage is the subject of research. The blocked-line pressure sensitivity curve, the leakage flow curve and the center flow curve are determined by experiment. Individual characteristics are determined for different working fluid temperatures and different supply pressures. The flow through internal leaks in the center position of the valve spool is determined by analytical calculations. The flow through internal leaks is also simulated using the Ansys Fluent software. Subsequently, the geometry of the flow simulation model is modified to take into account manufacturing tolerances. From simulation results, the effect of the manufacturing tolerance magnitude on the internal leakage of the directional valve is evaluated. Finally, simulated dependencies are compared with experimentally determined characteristics.