bluuebunny/crossref_metadata_2025 huggingface dataset:
Documentales, memorias y políticas (1985-2015): representaciones audiovisuales de juicios por violacion a los derechos humanos durante la última dictadura cívico-militar en Argentina
Authors: Nicola Mariné
Published: June 2024

En el presente trabajo nos proponemos analizar la producción fílmica documental argentina contemporánea que aborda los procesos de enjuiciamiento a responsables por violación a los derechos humanos durante la última dictadura cívico-militar en el país (1976-1983). Estudiamos estos documentales en su contexto de producción para analizarlos en el complejo entramado entre política y memoria, indagando sobre el rol de diversos agentes institucionales y actores sociales que interactúan en contextos socio-históricos donde las políticas en torno a la historia reciente van configurando diversas formas de revisitar el pasado y participan en las disputas por el sentido del pasado en el presente. Prestamos especial atención al rol del Estado como actor que interviene, promueve u obstruye el desarrollo y aplicación de políticas culturales destinadas al campo audiovisual, que resultan relevantes para la producción, difusión y circulación de estas representaciones audiovisuales documentales que realizan una relectura del pasado y el presente, interviniendo en el complejo proceso de rescatar voces y memorias. Al mismo tiempo, abordamos el análisis de las representaciones documentales en tanto prueba, evidencia y legibilidad de la historia reciente. Para ello focalizamos en la incorporación de testimonios e imágenes fotográficas en las narrativas audiovisuales, cómo se incorporan estos recursos en la representación documental.
Métodos de identificação humana em odontologia forense: uma revisão de literatura
Authors:   , Matos Ana Julia Bueno , Oliveira Lucas Eduardo , Moreira Moacir José , Benett Sarah Priscila Barisson
Published: June 2024

: A Odontologia Forense é um ramo da Odontologia que utiliza evidências dentárias como meio para identificar um indivíduo, comparando restos mortais ou indicativos dentários encontrados em uma cena de crime, com registros anteriores feitos pelo cirurgião-dentista. O profissional odontolegista desempenha um papel importante na identificação através de seus métodos que comumente são aplicados em casos de desastres em massa, acidentes de avião ou crimes violentos devido à grande capacidade de resistência e durabilidade dos dentes e de seus componentes, além do custo reduzido e rapidez que as técnicas agregam no momento da identificação. O presente estudo tem como objetivo apresentar os principais métodos de identificação, bem como apontar suas vantagens e desvantagens, ainda, demonstrar a importância do cirurgião-dentista dentro dos Instituto Médico Legal. Foram realizadas buscas nas bases de dados do PubMed, Scielo e Google acadêmico. Entre 2017 a 2023. Sendo assim, pode-se concluir que os métodos de identificação são de extrema importância quando aplicados com excelência pelo profissional habilitado da área.
Boletín informativo Número dieciséis: ¿Cómo mantener seguros sus dispositivos móviles?
Authors: Zambrano Hernández Fernando , Peña Hidalgo Hernando José , Nuñez Álvarez Yenny Stella , Cárdenas Corral Néstor Raúl
Published: June 2024

En la actualidad, los dispositivos se han convertido en un apoyo tecnológico para el desarrollo de nuestras actividades diarias. En estos, se almacena gran cantidad de información personal que pasa de datos de contacto hasta contraseñas y datos de orden financiero y de salud. Mantener seguros estos dispositivos que cada día están más presentes en nuestra vida cotidiana es una prioridad. Por consiguiente, es necesario conocer un poco sobre los riesgos a los que nos enfrentarnos y cómo hacer uso de herramientas que protejan nuestra privacidad y que prevenga posibles ciberataques.

El presente boletín muestra recomendaciones que contribuyen en optimizar la seguridad de nuestros dispositivos móviles
Characterization of anti-nuclear autoantibodies in Sudanese Patients with Human Immunodeficiency Virus after HAART receiving: a cross-sectional study
Authors: Hajhamed Nooh , Mohammed Salahdeen , Bakheit Abdullah , Mohamed Nouh , Ahmed Abdallah , Abdalla Abualgasim , Abdelbagi Abubakar , Allah Hassan Babieker Said Khalf , A Hussein. , Ali Mahjoob Mahjoob , Azhary Ayman , Hamida Mohammed Elfatih
Published: June 2024

Abstract Background: HIV infection triggers chronic inflammation and
disrupts B and T lymphocyte function. It causes widespread B cell
activation and molecular mimicry of viral proteins. Surprisingly, high
antiretroviral therapy (HAART) leads to immune reconstitution
inflammatory syndrome (IRIS), autoantibody production, and potentially
autoimmune diseases. This study aimed to investigate the proportion of
antinuclear autoantibodies (ANA) in HIV-infected patients and their
clinical significance Method: One hundred and sixteen (116) serum
samples from HIV-infected patients were subsequently admitted to a
military hospital. Voluntary Testing and Counseling (VTC) A clinical
center in the Sudanese state of Khartoum was tested for ANA screening,
clinically significant autoantibodies were defined as ANA titers. ≥1/80.
Result: 116 confirmed HIV patients, all receiving Highly Active
Anti-Retroviral Therapy, were screened for ANA autoantibodies using hep2
cell indirect immunofluorescent technique, using titer 1 80 as the
cutoff point for autoantibodies detection out of 116 HIV-infected
patients 85/116 (73.3%) showed positivity for ANA. Without a doubt, the
proportion of ANA positivity among the female group tends to be higher
than the male group 36/45 (80%) and 49/71 (69%), respectively, but
there are no significant statistical differences (p = 0.206).
Interestingly, a high proportion of positivity for ANA was found in the
older subject group (>60 years) 5/5 (100%) and all the
older groups were positive for ANA. Furthermore, the study also showed
that the predominant ANA patterns were fine speckled nuclear (56.5%)
and cytoplasmic fine granules (21.2%). Conclusion: This study suggests
that HIV-induced chronic inflammation may trigger the production of pf
autoantibodies with variable specificities, this may be due to molecular
mimicry or polyclonal activation, and HAART treatment may contribute to
these long-term effects, particularly during IRIS.
CHAINS OF TIME DEPENDENT 3D MATRICES AND APPLICATIONS TO CRYPTOGRAPHY
Authors: NARKUZIEV B.A. , VELASCO M. VICTORIA
Published: June 2024

This paper deals with chains of time-dependent 3D matrices and their
applications. We introduce the 3D rotation-chain 2×2×2 and describe the
properties of each 3D matrix in this chain after identifying it with the
non-associative algebra that it defines. To this end, we characterize
when the algebra associated with a 3D matrix of dimension 2×2×2 is
associative, commutative, has a unit (or a one-sided unit), or is a
division algebra, respectively. Based on the properties of the 3D
rotation-chain 2×2×2 we develop algorithms for encryption and decryption
processes.
Low energy expenditure at the edge of a seabird's winter range suggests energy underpins the Abundant Centre Hypothesis
Authors: Léandri-Breton Don-Jean , Elliott Kyle , Tarroux Arnaud , Legagneux Pierre , Jouanneau William , Amélineau Françoise , Angelier Frédéric , Blévin Pierre , Bråthen Vegard , Fauchald Per , Gabrielsen Geir , Goutte Aurélie , Tartu Sabrina , Moe B. , Chastel Olivier
Published: June 2024

Understanding how geographic range limits are shaped is a central and
challenging question in ecology that has become particularly critical in
the context of global environmental changes. While such limits are often
studied for resident or breeding species, range limits are equally
important for migratory species in winter when population regulation may
occur due to limited resources in the non-breeding season. A central
hypothesis in several theories for range limitations is that the
density, fitness and performance of individuals decrease towards the
edge of the range as organisms become maladapted when approaching the
limit of their environmental tolerance (‘Abundant-centre Hypothesis’).
Energy is a critical resource, especially in winter when environmental
conditions deteriorate, and this hypothesis predicts that high energy
expenditure (low performance) at the range limit would lead to rapidly
dwindling body mass and reduced fitness. We investigated this hypothesis
in an Arctic-breeding seabird wintering in the North-Atlantic, the
black-legged kittiwake (Rissa tridactyla). From 2008 to 2019, we tracked
117 adult kittiwakes (n=176 tracks) with geolocation devices and
saltwater immersion sensors to estimate the migratory strategies,
time-activity budget and energy expenditure of individuals during
winter, and estimated their reproductive success after their return to
the colony during summer. Population density was indeed higher towards
the center of the range. However, contrary to the predictions, the
energy expenditure of individuals was higher at the centre of the range
and decreased towards the edge. In contrast, there were no spatial
differences in the reproductive success of individuals wintering at the
centre versus at the edge of their range. We conclude that performance
and fitness did not increase towards the centre of the wintering range,
implying that although resource acquisition was likely higher at the
abundant centre, energy expenditure was also higher, so that individual
fitness was constant across the winter range.
Abstracts from the 7th IFPA Conference World Psoriasis & Psoriatic Arthritis Conference
Authors: Listed No authors
Published: June 2024

Abstracts from the 7th IFPA Conference World Psoriasis & Psoriatic Arthritis Conference
Measurement of lithium response in patients with bipolar disorder using the Retrospective Assessment of Response to Lithium Scale (Alda scale)
Authors: Lee Dong Eun , Baek Ji Hyun
Published: June 2024

Lithium is the first-line medication for the treatment of bipolar disorder (BD), but its exact biological mechanisms have not been identified. One of the major obstacles in lithium-related research is the difficulty in precisely and reliably measuring the response to lithium. The Alda scale was developed to retrospectively measure lithium response in a standardized way. However, several aspects should be considered in understanding previous studies that used the Alda scale. In this narrative review, we aim to review previous studies and present the limitations of prior findings. Additionally, we suggest future strategies for applying the Alda scale in measuring lithium response. Initial studies using the Alda scale mainly included patients who were on lithium monotherapy for a long-term period. However, lithium monotherapy is relatively rare in clinical practice. More importantly, in clinical practice, if patients do not respond well to lithium, clinicians do not prescribe it for a long-term period. Thus, a modified approach to include diverse patients is necessary to identify true poor responders. Most previous studies also mainly included European populations, and ancestrally diverse populations should be included in the research. Furthermore, applying the same scale to explore the effects of other medications would also enhance our understanding of the neurobiological mechanisms of psychiatric medications in BD. Applying electronic health record data in evaluating lithium response would soon facilitate large-scale studies. Future studies that include diverse clinical populations reflecting the clinical practice are necessary to advance precision psychiatry.
Transient urine leakage following cryoablation: case report
Authors: Park Byung Kwan
Published: June 2024

Urinary complications are uncommon after percutaneous cryoablation for the treatment of small cell carcinoma. This minimally invasive treatment results in less urothelial damage than other thermal ablation techniques. However, urine leakage can occur from the cryoablation track on which the applicator is placed during the procedure. However, only a small number of studies have investigated the clinical outcomes of post-cryoablation urinary complications. Recently, we encountered a case of urine leakage following computed tomography-guided cryoablation. The purpose of this case report is to describe the causes, findings, and management of post-cryoablation urine leakage.
Vi skal lege os til bedre kulturaktiviteter for børn – med play probes som børnecentreret designmetode
Authors: Feder Karen , Jespersen Emilie , Christiansen Line
Published: June 2024

Igennem et kvalitativt studie af en børnecentreret designproces i kulturskoleregi undersøger artiklen, hvordan brugen af den legende designmetode ’play probes’ kan være med til at afdække viden om børn og børns hverdagsliv, med henblik på at udvikle mere relevante og børnecentrerede kulturskoletilbud for børn og børnefamilier. Det er en generel udfordring, at de eksisterende kulturtilbud ofte kun når en smal gruppe af børn, og at mange børn slet ikke har mulighed for at deltage i børnekulturaktiviteterne. Kortlægningen og analysen af en børnecentreret udviklingsproces i kulturskoleprojektet ’Rammer der rummer’ viser, at brugen af play probes kan sikre, at tilbuddene bliver mere relevante ved at afspejle brugerne. Kulturtilbud, der er udviklet med inspiration fra børn, giver bedre mening for børnene, og samtidig sikres det, at det ikke kun er børnene, der skal tilpasse sig de voksnes opfattelse af børnekultur, men at de voksne også tilpasser sig børnenes kultur.
English abstract
We Have to Play to Make Better Cultural Activities for Children – With the Use of Play Probes as a Child-Centered Design Method
Through a qualitative study of a child-centered design process in a cultural school setting, this article examines how the use of the playful design method “play probes” can help uncover knowledge about children and children’s everyday life, the aim being to develop more relevant and child-centered culture school activities for children and families. Generally, it is a challenge that existing activities often only reach a narrow group of children, and that many children cannot participate in the activities at all. The mapping and analysis of a child-centered development process in the project “Rammer der rummer” [“Frames that Contain“] shows how the use of play probes can make the activities more relevant when they reflect the users. When developed with respect for and inspiration from children, they make more sense to the children. Also, it is ensures that children do not just have to adapt to the adult understanding of children’s culture, but that the adults also adapt to it.
Barnets rätt att tillhöra och vara med i samhället och kulturen
Authors: Granö Päivi Maaria
Published: June 2024

Med en viss generalisering kan sägas att artiklarna i detta nummer handlar i stort sett om demokrati och dess praktiker i en nordisk barndomskontext. Inkludering, rätten att bli sedd och hörd samt rätten att delta är de centrala aspekterna i artiklarna. Jag vill särskilt lyfta fram artiklarnas metodologi som ett viktigt bidrag till detta nummer. Inom barndomsforskningen kan man inte nog betona att metodologin är sammanflätad med forskningsämnet. Forskningsmaterialet i det här numret har samlats genom intervjuer med vuxna och genom videoinspelningar och observationer av autentiska situationer med barn. Artikeln om design är särskilt intressant med hänsyn till dess data, konkreta produkter av barnen. Att samla in data förutsätter en hög nivå av forskningsetik. Men en tolkningsprocess är lika sårbar. Artiklarna visar på forskarnas sensitiva förmåga att läsa forskningsmaterialet om barn och barndomen. Trots allt är vi produkter av vår kultur och vi agerar som medlemmar av vår kultur på ett sådant sätt att redan våra observationer om omgivningen är tolkningar. Det skulle därför vara viktigt att öppna upp sina egna utgångspunkter och göra kontexten synligare. Som ny redaktör för Barn fångade den här frågan min uppmärksamhet. I Norden lever vi i en viss etnocentrisk kultur. Pernille Juhl påpekar till exempel detta i sin artikel. Jag vill uppmana forskare att bli ännu mer kritiska i sin självreflektion över kulturen. Därför, låt mig börja med ett litet minne från min barndom.
English abstract
The Child's Right to Belong and Take Part in Society and Culture
Generalizing to a certain degree, it can be said that the articles in this issue are largely about democracy and its practices in a Nordic childhood context. Inclusion, the right to be seen and heard, and the right to participate are the central aspects of the articles. I would particularly like to emphasize the methodology of the articles as an important contribution to this issue. In childhood research, it cannot be emphasized strongly enough that methodology is intertwined with the research topic. The research material in this issue has been gathered through interviews with adults, video recordings, and observation of authentic situations with children. The article on design is fascinating for its data: the artefacts produced by children. Collecting data requires a high level of research ethics. However, the process of interpretation is equally vulnerable. The articles show researchers’ sensitivity to interpreting children and childhood. Nevertheless, we are products of our culture, and we act as members of our culture in such a way that our observations about the environment are already interpretations. It is, therefore, important for researchers to be open about their own starting points and contexts. As the new editor of Barn, this issue caught my attention. In the Nordic countries, we live in a particular ethnocentric culture. Pernille Juhl, for example, points this out in her article. I would urge researchers to be even more critical in their self-reflection on culture.
Case Report of Acute Necrotizing Encephalopathy of Childhood Challenge of Diagnostic and Treatment
Authors: EL KHETTAB Fatima zahra , Nde-Ngala M. , El Khayla F. , Berramou I. , Azzouzi B. El , Merbouh M. , Serhraoui H. , Mouaffak Y. , Jalal H. , Younouss S.
Published: June 2024

Acute Necrotizing Encephalopathy of Childhood (ANEC) is a rare disease with a higher prevalence in East Asia. It is characterized by symmetrical and multifocal involvement of areas including the thalamus, brainstem, cerebellum, and white matter. ANEC is associated with death as well as long-term neurological disabilities (sequelae) in individuals who survive. In this report, we describe a case of a child with acute neurological symptoms resulting from a possible infection and explain his brain MRI, and paraclinical symptoms.
Introduction: Acute necrotizing encephalopathy of childhood (ANEC) is a progressive encephalopathy. The aim of this study was to report a rare case of ANEC in an eleven-year-old child with bilateral thalamic necrosis. Case Presentation: An 11-year-old child presented four days before admission with an infectious episode characterized by fever (not quantified) and flu-like symptoms. This was further complicated by functional impotence of both lower limbs. MRI showed multiple cerebral lesions above and below the tentorial level, involving the brainstem, cerebellum, thalamus, and bilateral white matter. The patient received intravenous methylprednisolone 30 mg/kg/day and 2 mg/kg for 6 weeks. Discussion: Acute necrotizing encephalopathy of childhood (ANEC) is a rapidly progressing encephalopathy characterized by fever and a depressed level of consciousness. Diagnosis depends on clinical presentation and characteristic neuroimaging findings of abnormal signal flair T2 of the thalami and supratentorial region, followed by treatment with steroids and immunoglobulin, as well as supportive care. Patients with ANEC have a variable prognosis, but mortality is very high. Conclusion: ANEC is a rare neurological entity in children, and its treatment is challenging. Early interventions, including emergency intravenous methylprednisolone or immunoglobulin, or plasma exchange, or a combination of these treatments, are crucial. However, further studies are needed to establish consensus guidelines.
Penerapan Android Berbasis Teknologi Internet of Things (IoT) untuk Pengendali Smart Room
Authors: Ashshaff Ahmad Marzuky , Yusman Machudor , Kurniawan Didik
Published: June 2024

The increasing prevalence of theft and the diminishing availability of energy resources underscore the importance of prioritizing security and efficient resource utilization. The concept of a Smart Room, controlled seamlessly via Android-based Internet of Things (IoT) technology, addresses these concerns by enabling users to interact with and manage information within their living spaces. This study seeks to develop such a system to empower users in controlling electronic devices and room conditions more effectively. The development process entails establishing a prototype room outfitted with lighting, a fan, and a secure door, all controllable through a dedicated Android application. The system is organized into two primary modules to simplify operation and monitoring. The successful deployment of this system, validated through black box testing, underscores its efficacy in enhancing security and resource management, thereby promoting safety and sustainability in domestic settings
eWaste App: Aplikasi Mobile Berbasis Android sebagai Upaya Pengelolaan Limbah Buah-Buahan dan Sayuran
Authors: Alfrian Enggal , Kurniawan Didik , Irawati Anie Rose , Ardiansyah Ardiansyah
Published: June 2024

Advances in science and technology have rapidly progressed, playing a crucial role in addressing environmental issues. Among these, the problem of organic waste remains a significant concern that demands focused attention. One common method to reduce the volume of organic waste is incineration, but this approach is often ineffective as it can cause air pollution and, if not properly managed, can negatively impact human health. The lack of a digital system to manage organic waste has contributed to its persistent unresolved state. This research aims to develop an Android-based application, eWaste, for managing fruit and vegetable waste in Bandar Lampung city. The primary goal of this application is to address environmental problems, particularly organic waste. Using this application, waste is collected, sorted by type, and processed into useful products with economic value. The system was developed using the Waterfall method and programmed in the Java language. The application's functionality was evaluated through black box testing using the equivalence partitioning method. The outcome of this research is an application that facilitates the community, producers, and couriers in conducting transactions and arranging household waste pickups, thus contributing to better waste management.
Sistem Otomatisasi Pengairan Tanaman Hidroponik Berbasis NodeMCU ESP 8266
Authors: Soliata Ferdiansyah Aditya , Suryono Ryan Randy
Published: June 2024

Land conversion has a significant impact on the limited land area and water availability, particularly affecting agriculture. Water demand and quality are crucial for the growth and productivity of crops. One effective method for watering plants is aquaponics. In hydroponic systems, the timing of water distribution greatly influences the quality and quantity of fish and plants produced. The maximum turbidity level for hydroponics should not exceed 25 NTU. The purpose of developing this automated irrigation system is to assist aquaponic farmers and reduce losses. This research employs the prototype method, utilizing a turbidity sensor and an ultrasonic sensor, along with a water pump to regulate water flow to aquaponic plants. The system operates by sending sensor measurements to the NodeMCU ESP 8266 module, which then determines whether the water pump should be activated based on the sensor readings. This tool is designed to relieve farmers from the burden of manually monitoring their aquaponic systems, as it will automatically adjust water levels according to sensor data.
Haversine Geo-Spasial Data Android Model Untuk Optimasi Rute Kebersihan Lingkungan Terdekat
Authors: Herwanto Riko , Susanto Ferry , Dwi Rosmala , Prayoga M. Husain , Marta Dinata Riadi , Wamiliana Wamiliana
Published: June 2024

The urgency of environmental sustainability necessitates innovative solutions to address growing waste management challenges. This research investigates the development of a mobile application that utilizes geospatial data and the Haversine formula to optimize waste disposal efficiency in Indonesia. The dramatic increase in national waste generation, from 65.8 million tons in 2017 to 75.2 million tons in 2018, highlights the critical need for such interventions. The application leverages geotagging to pinpoint the nearest and most suitable waste disposal locations, streamlining the waste collection process for environmental workers. To ensure accurate distance calculations, the Haversine formula is employed, achieving an 84% accuracy rate with an average deviation of 112.522 meters. Black-box testing methodologies evaluate the application's interface functionality, while data-source optimization is explored to enhance application speed and waste collection route planning. This research contributes to the growing body of knowledge concerning technology-driven solutions for sustainable waste management practices.
Dialogues on statistics in scientific publications
Authors: Khromov-Borisov N. N.
Published: June 2024

A critical analysis of the article by S. V. Mylnikov (Scientific Editor and Publisher. 2023;8(1 Suppl):S52–S61) in the form of a correspondence dialogue is conducted. Aspects such as frequentist and Bayesian point and interval estimation of the parameters of binomial and polynomial distributions, linear correlation coefficient (r), coefficient of determination (R2), linear regression parameters, difference (PD) and proportion ratio (RR), odds ratio (OR), estimation of minimum required sample sizes, advantages of statistical estimation based on bootstrap, random number generator, graphical methods of statistical analysis: décolleté and whisker boxes, probability plots, histograms, Gardner-Altman plots, rain clouds, corrections for multiple comparisons, complexities of correlation analysis, effect size, replication probabilities (prep, psrep and prerep), mid-p values, prediction intervals for p values, for effect sizes, and for combined effects in meta-analysis. A description of the programs recommended for solving the discussed statistical problems is presented.
ADULT LEARNERS’ LANGUAGE ACQUISITION: A CASE STUDY OF IN-HOUSE TRAINING OF COMPANY “X” JAKARTA
Authors: Datu Yerly Arnold
Published: June 2024

The acquisition of English proficiency among adult learners is essential in today's globalized world, where English serves as the lingua franca of international business and communication. The demand for English proficiency extends beyond external business interactions to internal organizational processes, where effective communication within multicultural teams is crucial for collaboration and productivity. To thrive in the interconnected global economy, Indonesian companies must invest in English language training initiatives to equip their workforce with the necessary skills to navigate diverse work environments successfully. This descriptive qualitative study employing a case study approach aims at describing language acquisition of participants attending an in-house training called Business English program, obstacles faced, strategies applied as well as results obtained. The study also provides an overview of two analyses concerning challenges and strategies in adult language acquisition. The findings summarize participants’ profiles, revealing a gender skew towards females and varying levels of confidence despite strong motivation levels. Notably, it highlights that 75% of participants displayed mediocre speaking ability, while 25% exhibited low proficiency. Additionally, 75% had low confidence levels, contrasting with one participant's high confidence. All participants demonstrated strong motivation. Furthermore, improvements in fluency and accuracy skills are evident across participants, with scores increasing by an average of 7.9%. This indicates the effectiveness of instructional strategies in enhancing language proficiency. The analysis underscores the complex interplay between participant characteristics, instructional approaches, and language learning outcomes, offering insights for educators to tailor pedagogical strategies and create supportive environments conducive to adult language acquisition.
Designing a Game To Introduce and Educate Computational Thinking
Authors: Dhita Millen , Nugroho Erdhi Widyarto , Chandrawati T. Brenda
Published: June 2024

To prepare for the industrial era 4.0, the education system in Indonesia needs to change, from only providing learning materials to learning that involves students' ability to think creatively. One way to change this learning system is to implement other learning techniques that hone one's ability to be able to think creatively in solving a problem. One of these learning techniques is Computational Thinking or commonly abbreviated as CT. In Indonesia, Computational Thinking techniques have not been widely used in the teaching and learning process, therefore this research is intended to introduce Computational Thinking learning techniques through game media."Take Me Home" is the name of the game developed to support this research, "Take Me Home" is a serious game created to hone and introduce players to Computational Thinking learning techniques, the game "Take Me Home" is made attractive as possible so that players want to play it continuously by using a procedurally generated map players will always get a different form of game level every time they play the game "Take Me Home", having an Endless level also makes players feel challenged to keep playing.With "Take Me Home" it is hoped that players will learn how to solve problems using creative thinking and also get to know Computational Thinking techniques by designing games that are easy, interesting and educational researchers can also see whether the game "Take Me Home" will continue to be useful and players want to play “Take Me Home” in the future.
Replication kinetics and infectivity of SARS-CoV-2 Omicron variant sublineages recovered in the Republic of Korea
Authors: Kim Jeong-Min , Kim Dongju , Rhee Jee Eun , Yoo Cheon Kwon , Kim Eun-Jin
Published: June 2024

Objectives: We analyzed the correlation between the infectivity and transmissibility of the severe acute respiratory syndrome coronavirus 2 Omicron sublineages BA.1, BA. 2, BA.4, and BA.5.Methods: We assessed viral replication kinetics and infectivity at the cellular level. Nasopharyngeal and oropharyngeal specimens were obtained from patients with coronavirus disease 2019, confirmed using whole-genome sequencing to be caused by the Omicron sublineages BA.1, BA.2, BA.4, or BA.5. These specimens were used to infect Vero E6 cells, derived from monkey kidneys, for the purpose of viral isolation. Viral stocks were then passaged in Vero E6 cells at a multiplicity of infection of 0.01, and culture supernatants were harvested at 12-hour intervals for 72 hours. To evaluate viral replication kinetics, we determined the cycle threshold values of the supernatants using real-time reverse transcription polymerase chain reaction and converted these values to genome copy numbers.Results: The viral load was comparable between BA.2, BA.4, and BA.5, whereas BA.1 exhibited a lower value. The peak infectious load of BA.4 was approximately 3 times lower than that of BA.2 and BA.5, while the peak load of BA.2 and BA.5 was about 7 times higher than that of BA.1. Notably, BA.1 demonstrated the lowest infectivity over the entire study period.Conclusion: Our results suggest that the global BA.5 wave may have been amplified by the higher viral replication and infectivity of BA.5 compared to other Omicron sublineages. These analyses could support the rapid assessment of the impact of novel variants on case incidence.
Periodontitis and non-communicable diseases in a Brazilian population, a cross-sectional study, Vila Velha-ES, Brazil
Authors: de Mendonça Gustavo Vital , Junior Crispim Cerutti , Feitosa Alfredo Carlos Rodrigues , de Mendonça Brígida Franco Sampaio , Pimassoni Lucia Helena Sagrillo
Published: June 2024

Objectives: The objective of this study was to examine the hypothesis that periodontal disease is associated with chronic non-communicable diseases.Methods: In this cross-sectional study, we evaluated the periodontal health condition of the population, based on the community periodontal index, as well as the number of missing teeth and the presence of systemic health conditions. We quantified the association between oral health and the presence of chronic diseases using simple logistic regression, adjusting for confounding factors including age, smoking, and overweight.Results: The study population consisted of 334 volunteers, aged between 19 and 81 years. In patients over 45 years old, periodontal disease was found to be significantly associated with hypertension and diabetes. Furthermore, in female patients, periodontal disease was significantly associated with hypertension, diabetes, and cancer.Conclusion: Our findings indicate that periodontal disease is positively and significantly associated with both arterial hypertension and diabetes, independent of potential confounding factors.
Solute Carrier Transporters in Synovial Membrane and Hoffa’s Pad of Patients with Rheumatoid Arthritis
Authors: Malinowski Damian , Piotrowska Katarzyna , Droździk Marek , Pawlik Andrzej
Published: June 2024

Rheumatoid arthritis (RA) is a complex autoimmune disease that leads to joint destruction. A number of immune cells that affect joint tissues are involved in the pathogenesis of this disease. This leads to the synthesis of many pro-inflammatory mediators. The transport of drugs, as well as many cytokines involved in the development of inflammation in RA patients, is mediated by membrane transporters. Membrane transporters are proteins that mediate the transfer of substrates across biological membranes. But to date there are no studies examining the expression of solute carrier (SLC) transporters in joint tissues. The aim of the study was to evaluate the expression of individual SLC family transporters in the synovial membranes (SMs) and infrapatellar fat pad (Hoffa’s pad) of RA patients. The study included 20 patients with rheumatoid arthritis and 20 with osteoarthritis as the control group who were undergoing joint replacement surgery as a normal part of clinical care. In the SM and Hoffa’s pad of RA patients the following 17 membrane transporters were defined at relevant expression levels for SLC transporter superfamily: SLC15A2, SLC16A3, SLC19A1, SLC2A9, SLC22A1, SLC22A3, SLC22A4, SLC22A5, SLC22A18, SLC33A1, SLC47A1, SLC51A, SLC7A5, SLC7A6, SLC01C1, SLC02B1, SLC04A1. The confirmed expression of these transporters in the SMs as well as Hoffa’s pad of patients with RA and OA, and the differences in their expression between these groups, suggests the involvement of SLC transporters in both the maintenance of homeostasis under physiological conditions in the tissues of the joints, as well as in the inflammatory process in RA.
Securing Decentralized Storage in Blockchain: A Hybrid Cryptographic Framework
Authors: Swati Jadhav , Nitin Pise
Published: June 2024

The evolution of decentralized storage, propelled by blockchain advancements, has revolutionized data management. This paper focuses on content security in the InterPlanetary File System (IPFS), a leading decentralized storage network lacking inherent content encryption. To address this vulnerability, we propose a novel hybrid cryptographic algorithm, merging AES 128-bit encryption with Elliptic Curve Cryptography (ECC) key generation. The algorithm includes ECC key pairs, random IV generation, and content/AES key encryption using ECC public keys. Benchmarking against standard AES 256-bit methods shows a significant 20% acceleration in encryption speed and a 16% increase in decryption efficiency, affirming practicality for enhancing IPFS content security. This research contributes to securing decentralized storage and provides a performance-driven solution. The promising results highlight the viability of the proposed approach, advancing understanding and mitigating security concerns in IPFS and similar systems.
An Improved Parallel Biobjective Hybrid Real-Coded Genetic Algorithm with Clustering-Based Selection
Authors: Akopov Andranik S.
Published: June 2024

This work presents an improved parallel biobjective hybrid real-coded genetic algorithm (MORCGA-MOPSO-II). The approach is based on the combined use of the parallel Multi-Objective Real-Coded Genetic Algorithm (MORCGA) and the Multi-Objective Particle Swarm Optimization (MOPSO). At the same time, clustering-based selection techniques are used to form subpopulations of parent individuals. Using well-known clustering algorithms (e.g., k-Means, hierarchical clustering, c-means, and DBSCAN) in combination with the proposed clustering-based mutation (the CL-mutation) directed toward the obtained cluster centers allows for improving the quality of the Pareto fronts’ approximations. The results of the MORCGA-MOPSO-II were compared with other well-known multi-objective evolutionary algorithms (e.g., SPEA2, NSGA-II, FCGA, MOSPO, etc.). Moreover, the MORCGA-MOPSO-II was integrated with the previously developed agent-based model of a goods exchange through the objective functions. As a result, the Pareto fronts have been obtained for the agent-based model of a goods exchange in different configurations of the initial distribution of agents.
A Novel Deep Transfer Learning-Based Approach for Face Pose Estimation
Authors: Rusia Mayank Kumar , Singh Dushyant Kumar , Aquib Ansari Mohd.
Published: June 2024

An efficient face recognition system is essential for security and authentication-based applications. However, real-time face recognition systems have a few significant concerns, including face pose orientations. In the last decade, numerous solutions have been introduced to estimate distinct face pose orientations. Nevertheless, these solutions must be adequately addressed for the three main face pose orientations: Yaw, Pitch, and Roll. This paper proposed a novel deep transfer learning-based multitasking approach for solving three integrated tasks, i.e., face detection, landmarks detection, and face pose estimation. The face pose variation vulnerability has been intensely investigated here underlying three modules: image preprocessing, feature extraction module through deep transfer learning, and regression module for estimating the face poses. The experiments are performed on the well-known benchmark dataset Annotated Faces in the Wild (AFW). We evaluate the outcomes of the experiments to reveal that our proposed approach is superior to other recently available solutions.
Chrome-Free Sheep Leathers with Antimicrobiological Protection for Medical and Therapeutic Applications
Authors: Falkiewicz-Dulik Michalina
Published: June 2024

The paper presents the results of tests, and an evaluation of sheep leather quality, tanned according to the new chrome-free tanning technology. The leathers were tested for physico-chemical parameters and antimicrobial activity. The tests were performed in accordance with Polish standards. Sheep leathers tanned according to the technology developed were characterized by high durability, health and hygiene parameters. Sheep leather samples protected with a zinc pyrithione formulation, showed effective action against all pathogenic bacteria and fungi used in the study. Anti-decubitus sheets, made of sheep leathers with fleece were tested during use by immobilized people lying for a long time. The sheets were rated as comfortable for the sick in the prevention of bedsores and the formation of other skin lesions.
Pregnancy-Related Changes of the Blood Biochemical Profile in Ouled Djellal Ewe’s Breed Under Semi-Arid Conditions (Algeria)
Authors: Lamraoui Ramzi , Gherissi Djellal Eddine , Afri-Bouzebda Farida , Bouzebda Zoubir , Chacha Fayçal
Published: June 2024

In mammals, the pregnant female carries many physiological and anatomical changes. Biochemical profiles are very important tools for monitoring gestation progress. This study was designed to investigate pregnancy-related changes of blood metabolites in Ouled Djellal ewes under semi-arid conditions. Blood samples were collected from ten non pregnant multiparous ewes 4 weeks before conception and 4, 12 and 18 weeks of pregnancy age. The pattern of changes of some biochemical parameters were studied. Cholesterol level showed no significant changes during pregnancy, while triglyceride, AST and Ca decreased up to the 12th week of pregnancy, whereas the total protein, albumin, and creatinine increased toward the 12th week of pregnancy. Urea reached maximum levels at the end of the pregnancy, contrary to ALT that was significantly decreased. Glucose concentration showed a continual decrease varying from 2.08 ± 0.78 g.l−1 at the first month of pregnancy to 0.35 ± 0.36 g.l−1 at the 18th week of pregnancy. On the other hand, pregnancy establishment increased significantly the glucose, triglyceride, albumin, and urea, but it decreased significantly the cholesterol and creatinine levels. No differences were observed between pregnant and non-pregnant ewe for the rest of the parameters. These results demonstrated a clear evidence of pregnancy-related distribution of blood biochemical indices of Ouled Djellal ewe under semi-arid conditions. Some substrates and enzymes were mainly higher during the first half of pregnancy (triglyceride, AST and Ca), and some others increased from the mild pregnancy period (total protein, albumin and creatinine), while urea and ALT changes were observed at late pregnancy. The energetic demand increased with advancing pregnancy.
The Influence of the Combinative Continuous and Pulse Application of Lacto-Immuno-Vital Synbioticum on the Mucus Production Dynamics in Poultry Small Intestine
Authors: Szabóová Renáta , Herich Robert , Levkut Martin , Karaffová Viera , Revajová Viera , Ševčíková Zuzana , Gočová Andrea , Seman Vladimír , Faixová Zita
Published: June 2024

A great interest is placed on the influence of probiotic, prebiotic and synbiotic preparations on animals in accordance with the principle of One health. The small intestine mucosa represents a complex ecosystem ensuring the homeostasis of the animal organism. The effect of Lacto-Immuno-Vital synbiotic preparation on the quantity of mucin produced in the broiler chicken small intestine was studied. The chickens (7 days old Hybrid ROSS 308) were divided into 3 equal size (n = 16) groups, housed in separate halls: control group (CG), and two experimental groups that received syn-biotic preparation Lacto-Immuno-Vital, – one with continuous synbiotic administration (EGC), and another with pulsed synbiotic administration (EGP). The preparation was administered to EGC group from the experimental day 1 to day 7 continuously every day (500 g per 1000 l of drinking water.day−1), and to EGP group from experimental day 8 to day 22 in a pulsed manner (every third day) at a dose of 300 g per 1000 l of drinking water. The experiment lasted 22 days. A significant effect on mucus production quantity was found in the duodenum (P < 0.001), in EG after both types of synbiotic supplementation compared to CG. The comparison of continuous and pulsed supplementation was as follows: a significant effect (P < 0.001) was observed after continuous supplementation of the synbiotic preparation, compared to pulsed supplementation in EG.
Fenye by the Numbers: A Quantitative Analysis of Astrological Contents in Chinese Local Gazetteers
Authors: Chen Shih-Pei
Published: June 2024

Fenye (分野, lit., “field allocation”), is a traditional Chinese astrological system that associated celestial phenomena with regions on earth since ancient times. During middle and late imperial China, many literati writings criticized this system as illogical. Yet in the local gazetteers that were compiled in late imperial China to document local data within each administrative region, compilers continued to use fenye as the canonical way to identify their regions within the vast empire. The Jesuit introduction of Western sciences to China, in particular the technology that could precisely locate any place or region with latitude and longitude, appeared to render fenye obsolete, which fueled even more literati criticism. Modern scholars consider the public criticism from the Qianlong emperor and the resulting removal of fenye from the 1781 Rehe Gazetteer the end of fenye in imperial orthodoxy. However, by quantitatively analyzing a collection of 4,410 titles of local gazetteers and their section headings, this paper reveals many examples of local literati who resisted removing fenye entirely from their local history, well into the late Republican period.
An Encounter of Incommensurables: European Cosmological Knowledge in the Fenye Chapters of Chinese Local Gazetteers (1660-1820)
Authors: Wu Huiyi
Published: June 2024

It has often been argued that the introduction of early modern European cosmology at the turn of the seventeenth century by Jesuit missionaries—subsumed under the generic term “Western learning” (xixue 西學)—signalled the demise of traditional fenye (分野, or “field allocation”) theory, as the concept of Earth’s sphericity and the widened sense of world geography are fundamentally at odds with the Sinocentric worldview underpinning fenye. However, the fenye chapters in Qing dynasty local gazetteers tell a different story: in comparison with earlier Ming gazetteers their proportion increased. These chapters rarely take a stance against Western learning. Rather, they invoke Western learning as part and parcel of the imperially sanctioned astronomy to be reckoned with, or even suggest it as a remedy for flaws in traditional fenye techniques, leading to a plurality of discourses in which Sino-Western relationships become entangled with tension between the imperial and the local. This phenomenon is particularly visible in the peripheral regions of the empire, such as Guangxi, as these were traditionally marginalised in the Sinocentric cosmology of the fenye system. This paper explores cosmological discourses to answer the following questions: What were the agendas that Western learning was made to serve in these gazetteers? How did local endeavours relate to court-sponsored imperial projects? What were their sources of knowledge on matters of Western learning, and how can we map out the geography of Western learning based on these local sources?
From Fenye to Fengshui: Applying Correlative Cosmography in Late Imperial China
Authors: Brown Tristan G.
Published: June 2024

This paper documents the resilience of fenye (分野, lit., “field allocation”) and its applications through the nineteenth century in China. Despite literati (and eventually imperial) criticisms that the fenye system of correlative cosmography was outdated and unworthy of belief, fenye retained a sizeable audience through the close of the Qing period. At the top, the Qing imperial state continued to reference fenye correlations in its official communications late into the dynasty. In local society, literati looked to newly issued dynastic sources of astrological knowledge to update local gazetteers; in the nineteenth century, these trends were pronounced along frontier areas lacking longstanding gazetteer records. Finally, people engaged in the practice of fengshui looked to fenye knowledge to update the values and layout of the compass, the historical origins of which related to geomantic practices. In the Qing period, the compass was both theoretically and physically altered under the influence of Jesuit-introduced “Western Learning” (Xixue 西學). The paper contends that the status of fenye in pre-twentieth century China was seldom an allor-nothing proposition between a celebrated component of imperial orthodoxy and an outdated relic in inexorable decline: people critiqued fenye, used fenye, and updated fenye.