bluuebunny/crossref_metadata_2025 huggingface dataset:
Jet timing
Authors: Chiu Wen Han , Liu Zhen , Low Matthew , Wang Lian-Tao
Published: January 2022

Abstract

The measurement of the arrival time of a particle, such as a lepton, a photon, or a pion, reaching the detector provides valuable information. A similar measurement for a hadronic final state, however, is much more challenging as one has to extract the relevant information from a collection of particles. In this paper, we explore various possibilities in defining the time of a jet through the measurable arrival times of the jet constituents. We find that a definition of jet time based on a transverse momentum weighted sum of the times of the constituents has the best performance. For prompt jets, the performance depends on the jet trajectory. For delayed jets, the performance depends on the trajectory of the jet, the trajectory of the mother particle, and the location of the displaced vertex. Compared to the next-best-performing jet time definition, the transverse momentum weighted sum has roughly a factor of ten times better jet time resolution. We give a detailed discussion of the relevant effects and characterize the full geometrical dependence of the performance. These results highlight the critical importance of using a proper definition of jet time with its corresponding detector-dependent calibration and the exciting possibility of deepening our understanding of jets in the time domain.
Baryogenesis from ultra-slow-roll inflation
Authors: Wu Yi-Peng , Pinetti Elena , Petraki Kalliopi , Silk Joseph
Published: January 2022

Abstract

The ultra-slow-roll (USR) inflation represents a class of single-field models with sharp deceleration of the rolling dynamics on small scales, leading to a significantly enhanced power spectrum of the curvature perturbations and primordial black hole (PBH) formation. Such a sharp transition of the inflationary background can trigger the coherent motion of scalar condensates with effective potentials governed by the rolling rate of the inflaton field. We show that a scalar condensate carrying (a combination of) baryon or lepton number can achieve successful baryogenesis through the Affleck-Dine mechanism from unconventional initial conditions excited by the USR transition. Viable parameter space for creating the correct baryon asymmetry of the Universe naturally incorporates the specific limit for PBHs to contribute significantly to dark matter, shedding light on the cosmic coincidence problem between the baryon and dark matter densities today.
Random matrix theory for complexity growth and black hole interiors
Authors: Kar Arjun , Lamprou Lampros , Rozali Moshe , Sully James
Published: January 2022

Abstract

We study a precise and computationally tractable notion of operator complexity in holographic quantum theories, including the ensemble dual of Jackiw-Teitelboim gravity and two-dimensional holographic conformal field theories. This is a refined, “microcanonical” version of K-complexity that applies to theories with infinite or continuous spectra (including quantum field theories), and in the holographic theories we study exhibits exponential growth for a scrambling time, followed by linear growth until saturation at a time exponential in the entropy — a behavior that is characteristic of chaos. We show that the linear growth regime implies a universal random matrix description of the operator dynamics after scrambling. Our main tool for establishing this connection is a “complexity renormalization group” framework we develop that allows us to study the effective operator dynamics for different timescales by “integrating out” large K-complexities. In the dual gravity setting, we comment on the empirical match between our version of K-complexity and the maximal volume proposal, and speculate on a connection between the universal random matrix theory dynamics of operator growth after scrambling and the spatial translation symmetry of smooth black hole interiors.
International Pesticide Operator Safety Meeting 2021: hand-held application scenarios in low- and middle-income countries
Authors: Röver Markus , Shaw Anugrah , Kuster Christian J.
Published: January 2022

An international web meeting on the topic of operator safety for pesticide operators was held on 20–21 September 2021. The meeting provided an opportunity for experts from regulatory agencies, pesticide industry, the Food and Agriculture Organization (FAO), and other organizations to discuss operator safety in low- and middle-income countries (LMIC). The meeting focused on risk assessment and risk mitigation, the first steps to address operator safety. The key message at the meeting was the need for an operator exposure model that includes common hand-held scenarios used in LMIC and consistent personal protective equipment communication. The experts supported a transparent collaborative process that will enable us to build on the past efforts.
Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells
Authors: Sanchez-Collado Jose , Lopez Jose J. , Jardin Isaac , Berna-Erro Alejandro , Camello Pedro J. , Cantonero Carlos , Smani Tarik , Salido Gines M. , Rosado Juan A.
Published: January 2022

The identification of two variants of the canonical pore-forming subunit of the Ca2+ release-activated Ca2+ (CRAC) channel Orai1, Orai1α and Orai1β, in mammalian cells arises the question whether they exhibit different functional characteristics. Orai1α and Orai1β differ in the N-terminal 63 amino acids, exclusive of Orai1α, and show different sensitivities to Ca2+-dependent inactivation, as well as distinct ability to form arachidonate-regulated channels. We have evaluated the role of both Orai1 variants in the activation of TRPC1 in HeLa cells. We found that Orai1α and Orai1β are required for the maintenance of regenerative Ca2+ oscillations, while TRPC1 plays a role in agonist-induced Ca2+ influx but is not essential for Ca2+ oscillations. Using APEX2 proximity labeling, co-immunoprecipitation and the fluorescence of G-GECO1.2 fused to Orai1α our results indicate that agonist stimulation and Ca2+ store depletion enhance Orai1α–TRPC1 interaction. Orai1α is essential for TRPC1 plasma membrane location and activation. Thus, TRPC1 function in HeLa cells depends on Ca2+ influx through Orai1α exclusively.
Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy
Authors: Mitrović Ana , Završnik Janja , Mikhaylov Georgy , Knez Damijan , Pečar Fonović Urša , Matjan Štefin Petra , Butinar Miha , Gobec Stanislav , Turk Boris , Kos Janko
Published: January 2022

New therapeutic targets that could improve current antitumor therapy and overcome cancer resistance are urgently needed. Promising candidates are lysosomal cysteine cathepsins, proteolytical enzymes involved in various critical steps during cancer progression. Among them, cathepsin X, which acts solely as a carboxypeptidase, has received much attention. Our results indicate that the triazole-based selective reversible inhibitor of cathepsin X named Z9 (1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-((4-isopropyl-4H-1,2,4-triazol-3-yl)thio)ethan-1-one) significantly reduces tumor progression, both in vitro in cell-based functional assays and in vivo in two independent tumor mouse models: the FVB/PyMT transgenic and MMTV-PyMT orthotopic breast cancer mouse models. One of the mechanisms by which cathepsin X contributes to cancer progression is the compensation of cathepsin-B activity loss. Our results confirm that cathepsin-B inhibition is compensated by an increase in cathepsin X activity and protein levels. Furthermore, the simultaneous inhibition of both cathepsins B and X with potent, selective, reversible inhibitors exerted a synergistic effect in impairing processes of tumor progression in in vitro cell-based assays of tumor cell migration and spheroid growth. Taken together, our data demonstrate that Z9 impairs tumor progression both in vitro and in vivo and can be used in combination with other peptidase inhibitors as an innovative approach to overcome resistance to antipeptidase therapy.
Warm sheet metal forming of energy-absorbing elements made 7075 aluminum alloy in the hardened state T6
Authors: Jaśkiewicz Karol , Skwarski Mateusz , Kaczyński Paweł , Gronostajski Zbigniew , Polak Sławomir , Trzpis Przemysław
Published: January 2022

The article covers experimental research on the forming of products made of 7075 aluminum alloy. This aluminum alloy grade is characterized by high strength, but due to its low formability in T6 temper, its use in the stamping processes of complex structural elements is limited. The authors have manufactured a U-shaped element at an elevated temperature and determined the optimal parameters of the process. Conventional heating of the sheet and shaping it at the temperature of 100 and 150 °C allowed to obtain a product of high strength similar to the T6 state, above 540 MPa. Due to the excessive springback of the sheet during forming, these products were characterized by a large deviation of the shape geometry, exceeding the allowable values of + / − 1 mm. Only the use of an alternative method of heating the sheet to temperatures of 200 and 240 °C (between plates at 350 °C, heating time 2 min, heating rate 1.8 °C/s) allowed to obtain a product that meets both the strength and geometric requirements. The determined optimal process’ parameters were later transferred to the stamping process of elements of a more complex shape (lower part of the B-pillar). The sheet was heated up and formed in the previously pre-heated tools. In the subsequent series of tests, the heating method and the blank’s temperature were being analyzed. In the case of the foot of the B-pillar, it was necessary to lower the initial blank temperature to 200 °C (heating in a furnace with a temperature of 340 °C, heating speed 0.5 °C/s). The appropriate combination of the process parameters resulted in the satisfactory shape deviation and reaching the product’s strength comparable to the strength of the material in as-delivered T6 temper. Using electron microscopy, it was verified that the structure of the finished product contained particles MgZn2 that strongly strengthen the alloy. The obtained results complement the data on the possibility of using 7075 aluminum alloy to produce energy-absorbing elements of motor vehicles.
Li–Yau inequalities for general non-local diffusion equations via reduction to the heat kernel
Authors: Weber Frederic , Zacher Rico
Published: January 2022

We establish a reduction principle to derive Li–Yau inequalities for non-local diffusion problems in a very general framework, which covers both the discrete and continuous setting. Our approach is not based on curvature-dimension inequalities but on heat kernel representations of the solutions and consists in reducing the problem to the heat kernel. As an important application we solve a long-standing open problem by obtaining a Li–Yau inequality for positive solutions u to the fractional (in space) heat equation of the form $$(-\Delta )^{\beta /2}(\log u)\le C/t$$

(
-
Δ
)

β
/
2

(
log
u
)

≤
C
/
t

, where $$\beta \in (0,2)$$

β
∈
(
0
,
2
)

. We also show that this Li–Yau inequality allows to derive a Harnack inequality. We further illustrate our general result with an example in the discrete setting by proving a sharp Li–Yau inequality for diffusion on a complete graph.
[68 Ga]Ga-FAPI uptake correlates with the state of chronic kidney disease
Authors: Conen Patrick , Pennetta Francesca , Dendl Katharina , Hertel Fabian , Vogg Andreas , Haberkorn Uwe , Giesel Frederik L. , Mottaghy Felix M.
Published: January 2022

Purpose

Kidney fibrosis leads to a progressive reduction in kidney function ultimately resulting in kidney failure. Diagnostic tools to detect kidney fibrosis are all invasive in nature requiring kidney biopsies with subsequent histological validation. In this retrospective study, the diagnostic value of three different radiotracers for the noninvasive prediction of kidney fibrosis was analyzed, taking into account the glomerular filtration rate (GFR) and the intra-renal parenchymal radiotracer uptake.

Methods

In 81 patients receiving either one of the following molecular imaging probes, [68 Ga]Ga-FAPI, [68 Ga]Ga-PSMA, or [68 Ga]Ga-DOTATOC, kidney function parameters were correlated with SUVmax and SUVmean of the renal parenchyma and background activity measured in lung parenchyma, myocardium, gluteal muscle, and the abdominal aorta. Patients were clustered according to their grade of chronic kidney disease (CKD), and a regression analysis and one-way ANOVA were conducted in this retrospective analysis.

Results

We found a negative correlation between GFR and [68 Ga]Ga-FAPI uptake for both SUVmax and SUVmean values, whereas background activity showed no correlation with GFR. [68 Ga]Ga-DOTATOC and [68 Ga]Ga-PSMA did not correlate between CKD stage and intra-renal parenchymal radiotracer uptake. Only [68 Ga]Ga-PSMA background activity exhibited a positive correlation with GFR suggesting an unspecific binding/retention potentially due to longer circulation times.

Conclusion

There is a significant negative correlation between renal parenchymal [68 Ga]Ga-FAPI uptake and GFR, which was not the case for [68 Ga]Ga-DOTATOC and [68 Ga]Ga-PSMA. This correlation suggests a specific binding of FAPI rather than a potential unspecific retention in the renal parenchyma, underlining the potential value of [68 Ga]Ga-FAPI for the noninvasive quantitative evaluation of kidney fibrosis.
The tale of microencapsulated rifampicin: is it useful for the treatment of periprosthetic joint infection?
Authors: López-Torres Irene Isabel , Vaquero-Martín Javier , Torres-Suárez Ana-Isabel , Navarro-García Federico , Fraguas-Sánchez Ana-Isabel , León-Román Víctor Estuardo , Sanz-Ruíz Pablo
Published: January 2022

Purpose

Microencapsulation techniques have allowed the addition of rifampicin to bone cement, but its in vivo efficacy has not been proven. The aim of our study is to determine the superiority of cement containing gentamicin and rifampicin microcapsules in the treatment of PJI versus cement exclusively containing gentamicin.

Methods

An S. aureus PJI was induced in 15 NZW rabbits. A week after inoculation, the first stage of replacement was carried out, and the animals were divided into two groups: group R received a spacer containing gentamicin and rifampicin microcapsules, and group C received a spacer containing gentamicin. Intra-articular release curve of rifampicin and infection and toxicity markers were monitored for four weeks post-operatively, when microbiological analysis was performed.

Results

The microbiological cultures showed a significantly lower growth of S. aureus in soft tissue (2.3·104 vs 0; p = 0.01) and bone (5.7·102 vs 0; p = 0.03) in the group with rifampicin microcapsules. No differences were found in systemic toxicity markers. Rifampicin release from the cement spacer showed higher concentrations than the staphylococcal MIC throughout the analysis.

Conclusion

The in vivo analyses demonstrated the superiority of cement containing gentamicin and rifampicin microcapsules versus the isolated use of gentamicin in the treatment of PJI in the rabbit model without serious side effects due to the systemic absorption of rifampicin. Given the increasing incidence of staphylococci-related PJI, the development of new strategies for intra-articular administration of rifampicin for its treatment has a high clinical impact.
High-power single-mode 894 nm VCSELs operating at high temperature (> 2 mW @ 365 K)
Authors: Ii Xue , Zhou Yinli , Zhang Xing , Zhang Jianwei , Zeng Yugang , Ning Yongqiang , Wang Lijun
Published: January 2022

In this study, we realize the high-power output of a single-mode 894 nm vertical-cavity surface-emitting laser (VCSEL) at high temperature. The effects of the dimensional parameters of oxide aperture and surface relief on the transverse mode and threshold gain of VCSEL were analyzed. Through collaborative optimization of the oxide aperture and relief, the VCSEL with 8 µm oxide aperture diameter and 5 µm surface relief inner diameter can operate at high temperature of 365 K with single-mode output power of 2.02 mW and side-mode suppression of 29.2 dB.
The effect of coffee/caffeine on postoperative ileus following elective colorectal surgery: a meta-analysis of randomized controlled trials
Authors: Yang Tzu-Wei , Wang Chi-Chih , Sung Wen-Wei , Ting Wen-Chien , Lin Chun-Che , Tsai Ming-Chang
Published: January 2022

Purpose

Postoperative ileus (POI) is the most common complication of elective colon resection. Coffee or caffeine has been reported to be useful in improving gastrointestinal function after abdominal surgery. This study aimed to investigate the effect of coffee/caffeine on POI in patients undergoing elective colorectal surgery.

Methods

We searched Cochrane library, Embase, PubMed, and ClinicalTrials.gov (until July 2021) to identify randomized controlled trials (RCTs) evaluating the effect of coffee or caffeine on bowel movements and POI in patients undergoing elective colorectal surgery. The mean difference (MD) for continuous outcomes and risk ratio (RR) for dichotomous outcomes were calculated and are presented with 95% confidence intervals (CIs). A random effects model was used in all meta-analyses.

Results

A total of four RCTs including 312 subjects met the inclusion criteria and were included in the meta-analysis. Postoperative coffee or caffeine consumption decreased the time to first bowel movement (MD, − 10.36 h; 95% CI, − 14.61 to − 6.11), shortened the length of hospital stay (MD, − 0.95 days; 95% CI, − 1.57 to − 0.34), and was associated with a decreased risk of the use of any laxatives after the procedure (RR, 0.64; 95% CI, 0.44 to 0.92). The time to first flatus, time to tolerance of solid food, risk of any postoperative complication, postoperative reinsertion of a nasogastric (NG) tube, and anastomotic leakage showed no statistical differences between groups.

Conclusion

Postoperative coffee or caffeine consumption improved bowel movement and decreased the duration of hospital stay in patients undergoing elective colorectal surgery. This method is safe and can prevent or treat POI.
Digital embryos: a novel technical approach to investigate perceptual categorization in pigeons (Columba livia) using machine learning
Authors: Pusch Roland , Packheiser Julian , Koenen Charlotte , Iovine Fabrizio , Güntürkün Onur
Published: January 2022

Pigeons are classic model animals to study perceptual category learning. To achieve a deeper understanding of the cognitive mechanisms of categorization, a careful consideration of the employed stimulus material and a thorough analysis of the choice behavior is mandatory. In the present study, we combined the use of “virtual phylogenesis”, an evolutionary algorithm to generate artificial yet naturalistic stimuli termed digital embryos and a machine learning approach on the pigeons’ pecking responses to gain insight into the underlying categorization strategies of the animals. In a forced-choice procedure, pigeons learned to categorize these stimuli and transferred their knowledge successfully to novel exemplars. We used peck tracking to identify where on the stimulus the animals pecked and further investigated whether this behavior was indicative of the pigeon’s choice. Going beyond the classical analysis of the binary choice, we were able to predict the presented stimulus class based on pecking location using a k-nearest neighbor classifier, indicating that pecks are related to features of interest. By analyzing error trials with this approach, we further identified potential strategies of the pigeons to discriminate between stimulus classes. These strategies remained stable during category transfer, but differed between individuals indicating that categorization learning is not limited to a single learning strategy.
Sourcing decision under interconnected risks: an application of mean–variance preferences approach
Authors: Mukherjee Soumyatanu , Padhi Sidhartha S.
Published: January 2022

Supply chains are customarily associated with multiple interconnected risks originated from supply side, demand side, or from the unanticipated background uncertainties faced by a firm. Also, effective functioning of supply chain hinges on sourcing decisions of inputs (raw materials). Therefore, there is a striking need to analyse the risk preference of the decision maker while going for optimal sourcing decision under varying degree of interconnected supply chain risks. This study addresses this issue by analysing the comparative static effects under interconnected supply chain risks for a risk averse decision-maker, manufacturing and selling products in a regulated market under perfect competition. The decision-maker faces not only supply-side risk (due to random input material prices) but also interconnected risks arising out of background risk (setup costs risk) and demand-side risk (output prices risk). With preferences defined over the mean and standard deviation of the uncertain final profit, this study illustrates the effects of the changes in the pairwise correlations between the three above mentioned risks on the optimum input choice of the manufacturer. To contextualise this study, an India-based generic drug manufacturer cum seller has been considered as a case in the parametric example of our model. Adaptation of the mean–variance framework helps obtaining all the results in terms of the relative trade-off between risk and return, with simple yet intuitive interpretations.
Factors Influencing Attendees’ Engagement with Group Psychoeducation: A Multi-stakeholder Perspective
Authors: Higgins Agnes , Downes Carmel , Murphy Rebecca , Barry Jennifer , Monahan Mark , Doyle Louise , Gibbons Patrick
Published: January 2022

Few studies have explored the problem of engagement in relation to group psychoeducation from a multi-site and multi-stakeholder perspective. The aim of the study was to explore the factors influencing service user and family engagement with group psychoeducation programmes. The study design was qualitative descriptive. Data were collected through individual and focus group interviews with key stakeholders (n = 75) involved with the programme within 14 mental health sites in the Republic of Ireland. Enablers and barriers to engagement were identified at participant, provider, programme and organization level. Motivated participants and engaged clinicians, peer co-facilitation and support, and skilled and responsive facilitators were some of the factors which enhanced engagement. Barriers to engagement included readiness among participants, concerns related to stigma and confidentiality, desire to distance oneself from mental health services, a lack of support for programme participation within families, group discomfort, the time and length of the programme, issues with transport, visibility of the programme, and structural supports for clinicians. Findings from the study illustrate the multifaceted nature of engagement as well as provide a greater understanding of the multifactorial influences on engagement. Strategies to enhance engagement should therefore reflect a multipronged approach. At the outset of programme implementation, organizations should address their readiness to engage, conduct local needs assessments to anticipate individuals’ needs and plan accordingly in order to maximize engagement, and bolster facilitators’ engagement skills through the provision of training and mentoring opportunities.
Public Perceptions of Child Pornography and Child Pornography Consumers
Authors: Steel Chad M. S. , Newman Emily , O’Rourke Suzanne , Quayle Ethel
Published: January 2022

Understanding the public’s perceptions of child pornography helps identify gaps in awareness and knowledge, impacts legislative decision making, quantifies stigmatization, and provides a baseline for identifying differences between lay and offender populations for clinical purposes. This research provides a comprehensive public survey assessing these issues. An Internet-based sample of 524 adults (mean age = 47 years, 51% female) within the USA were asked about their understanding and beliefs related to child pornography and individuals who view child pornography. The questions covered three topic areas—general perceptions of child pornography, endorsement of child pornography beliefs, and opinions related to the legality of various forms of child pornography as well as the decision making related to sentencing and sex offender registration for child pornography consumers. The research found that the public viewed these offenses as more severe than most other crimes and that there was an overestimation by the public of risks related to recidivism and contact offending. Additionally, the research found that there was support for most of the current sentencing guidelines in the USA, including sex offender registration, and that there was limited support for treatment over incarceration.
Long-term association of pregnancy and maternal brain structure: the Rotterdam Study
Authors: Aleknaviciute Jurate , Evans Tavia E. , Aribas Elif , de Vries Merel W. , Steegers Eric A. P. , Ikram Mohammad Arfan , Tiemeier Henning , Kavousi Maryam , Vernooij Meike W. , Kushner Steven A.
Published: January 2022

The peripartum period is the highest risk interval for the onset or exacerbation of psychiatric illness in women’s lives. Notably, pregnancy and childbirth have been associated with short-term structural and functional changes in the maternal human brain. Yet the long-term effects of pregnancy on maternal brain structure remain unknown. We investigated a large population-based cohort to examine the association between parity and brain structure. In total, 2,835 women (mean age 65.2 years; all free from dementia, stroke, and cortical brain infarcts) from the Rotterdam Study underwent magnetic resonance imaging (1.5 T) between 2005 and 2015. Associations of parity with global and lobar brain tissue volumes, white matter microstructure, and markers of vascular brain disease were examined using regression models. We found that parity was associated with a larger global gray matter volume (β = 0.14, 95% CI = 0.09–0.19), a finding that persisted following adjustment for sociodemographic factors. A non-significant dose-dependent relationship was observed between a higher number of childbirths and larger gray matter volume. The gray matter volume association with parity was globally proportional across lobes. No associations were found regarding white matter volume or integrity, nor with markers of cerebral small vessel disease. The current findings suggest that pregnancy and childbirth are associated with robust long-term changes in brain structure involving a larger global gray matter volume that persists for decades. Future studies are warranted to further investigate the mechanism and physiological relevance of these differences in brain morphology.
Identification of candidate type 3 effectors that determine host specificity associated with emerging Ralstonia pseudosolanacearum strains
Authors: Bocsanczy Ana M. , Bonants Peter , van der Wolf Jan , Bergsma-Vlami Maria , Norman David J.
Published: January 2022

Ralstonia pseudosolanacearum (Rps), previously known as R. solanacearum phylotypes I and III is one of the causal agents of bacterial wilt, a devastating disease that affects more than 250 plant species. Emerging Rps strains were identified infecting new hosts. P824 Rps strain was isolated from blueberry in Florida. Rps strains including PD7123 were isolated from hybrid tea roses in several countries through Europe. P781 is a representative strain of Rps commonly found on mandevilla in Florida. UW757 is a strain isolated from osteospermum plants originating in Guatemala. These strains are phylogenetically closely related and of economic importance on their respective hosts. The objective of this study is to associate the Type 3 Effectors (T3Es) repertoire of these four strains with host specificity. Candidate T3E associated with host specificity to blueberry, tea rose, osteospermum, and mandevilla were identified by sequence homology. Pathogenicity assays on 8 hosts including, blueberry, mandevilla, osteospermum and tea rose with the 4 strains showed that both P824 and PD7123 are pathogenic to blueberry and tea rose. P781 is the only strain pathogenic to mandevilla and P824 is the only strain non-pathogenic to osteospermum. Hypotheses based on correlation of T3E presence/absence and pathogenicity profiles identified 3 candidate virulence and 3 avirulence T3E for host specificity to blueberry and tea rose. Two candidate avirulence T3E were identified for mandevilla, and one candidate virulence for osteospermum. The strategy applied here can be used to reduce the number of host specificity candidate genes in closely related strains with different hosts.
Rapid Variations of Earth’s Core Magnetic Field
Authors: Lesur V. , Gillet N. , Hammer M. D. , Mandea M.
Published: January 2022

Evidence of fast variations in the Earth’s core field are seen both in magnetic observatory and satellite records. We present here how they have been identified at the Earth’s surface from ground-based observatory records and how their spatio-temporal structure is now characterised by satellite data. It is shown how their properties at the core mantle boundary are extracted through localised and global modelling processes, paying particular attention to their time scales. Finally are listed possible types of waves in the liquid outer core, together with their main properties, that may give rise to these observed fast variations.
Antiviral T-Cell Frequencies in a Healthy Population: Reference Values for Evaluating Antiviral Immune Cell Profiles in Immunocompromised Patients
Authors: Schulze Lammers Friederike C. , Bonifacius Agnes , Tischer-Zimmermann Sabine , Goudeva Lilia , Martens Jörg , Lepenies Bernd , von Karpowitz Maria , Einecke Gunilla , Beutel Gernot , Skripuletz Thomas , Blasczyk Rainer , Beier Rita , Maecker-Kolhoff Britta , Eiz-Vesper Britta
Published: January 2022

Viral infections and reactivations are major causes of morbidity and mortality after hematopoietic stem cell (HSCT) and solid organ transplantation (SOT) as well as in patients with immunodeficiencies. Latent herpesviruses (e.g., cytomegalovirus, Epstein-Barr virus, and human herpesvirus 6), lytic viruses (e.g., adenovirus), and polyomaviruses (e.g., BK virus, JC virus) can cause severe complications. Antiviral drugs form the mainstay of treatment for viral infections and reactivations after transplantation, but they have side effects and cannot achieve complete viral clearance without prior reconstitution of functional antiviral T-cell immunity. The aim of this study was to establish normal ranges for virus-specific T-cell (VST) frequencies in healthy donors. Such data are needed for better interpretation of VST frequencies observed in immunocompromised patients. Therefore, we measured the frequencies of VSTs against 23 viral protein-derived peptide pools from 11 clinically relevant human viruses in blood from healthy donors (n = 151). Specifically, we determined the VST frequencies by interferon-gamma enzyme-linked immunospot assay and classified their distribution according to age and gender to allow for a more specific evaluation and prediction of antiviral immune responses. The reference values established here provide an invaluable tool for immune response evaluation, intensity of therapeutic drugs and treatment decision-making in immunosuppressed patients. This data should make an important contribution to improving the assessment of immune responses in immunocompromised patients.
Learning from EMG: semi-automated grading of facial nerve function
Authors: Holze Magdalena , Rensch Leonhard , Prell Julian , Scheller Christian , Simmermacher Sebastian , Scheer Maximilian , Strauss Christian , Rampp Stefan
Published: January 2022

The current grading of facial nerve function is based on subjective impression with the established assessment scale of House and Brackmann (HB). Especially for research a more objective method is needed to lower the interobserver variability to a minimum. We developed a semi-automated grading system based on (facial) surface EMG-data measuring the facial nerve function of 28 patients with vestibular schwannoma surgery. The sEMG was recorded preoperatively, postoperatively and after 3–12 months. In addition, the HB grade was determined. After manual selection and preprocessing, the data were subjected to machine learning classificators (Logistic regression, SVM and KNN). Lateralization indices were calculated and multivariant machine learning analysis was performed according to three scenarios [differentiation of normal (1) and slight (2) vs. impaired facial nerve function and classification of HB 1-3 (3)]. The calculated AUC for each scenario showed overall good differentiation capability with a median AUC of 0.72 for scenario 1, 0.91 for scenario 2 and multiclass AUC of 0.74 for scenario 3. This study approach using sEMG and machine learning shows feasibility regarding facial nerve grading in perioperative VS-surgery setting. sEMG may be a viable alternative to House Brackmann regarding objective evaluation of facial function especially for research purposes.
Efficient 2D multiple attenuation using SRME with curvelet-domain subtraction
Authors: Lai Szu-Ying , Lin Yunung Nina , Hsu Ho-Han
Published: January 2022

Surface Related Multiple Elimination (SRME) usually suffers the issue of either over-attenuation that damages the primaries or under-attenuation that leaves strong residual multiples. This dilemma happens commonly when SRME is combined with least-squares subtraction. Here we introduce a more sophisticated subtraction approach that facilitates better separation of multiples from primaries. Curvelet-domain subtraction transforms both the data and the multiple model into the curvelet domain, where different frequency bands (scales) and event directions (orientations) are represented by a finite number of curvelet coefficients. When combined with adaptive subtraction in the time–space domain, this method can handle model prediction errors to achieve effective subtraction. We demonstrate this method on two 2D surveys from the TAiwan Integrated GEodynamics Research (TAIGER) project. With a careful parameter determination flow, our result shows curvelet-domain subtraction outperforms least-squares subtraction in all geological settings. We also present one failed case where specific geological condition hinders proper multiple subtraction. We further demonstrate that even for data acquired with short cables, curvelet-domain subtraction can still provide better results than least-squares subtraction. We recommend this method as the standard processing flow for multi-channel seismic data.
Ethnicity and Gender in Museum Representations of Human Evolution
Authors: Piqueras Jesús , Achiam Marianne , Edvall Susanna , Ek Charlotte
Published: January 2022

Scientific representations of human evolution often embrace stereotypes of ethnicity and gender that are more aligned with socio-cultural discourses and norms than empirical facts. The present study has two connected aims: to understand how ethnicity and gender are represented in an exhibition about human evolution, and to understand how that representation influences learners’ meaning making. First, we analysed an exhibition with realistic reconstructions of early hominids in a museum of natural history, to identify dualisms related to the representation of gender and ethnicity that have been recognised in research. Then, we studied the processes of meaning making in the exhibition during an out-of-school educational activity, in which groups of teenaged students explore and discuss the hominid reconstructions. Our results show that the exhibition displays human evolution in the form of a linear sequence from a primitive African prehistory to a more advanced European present. Behind this depiction of human evolution lies stereotypic notions of ethnicity and gender: notions that were incorporated into the students’ meaning making during the educational activity. When students noticed aspects of ethnicity, their meaning making did not dispute the messages represented in the exhibition; these were accepted as scientific facts. Conversely, when the students noticed aspects related to gender, they often adopted a more critical stance and challenged the representations from different perspectives. We discuss the implications of our findings for exhibit design and evolution education more generally. In doing so, we offer our perspectives on the design of learning environments to salvage inherently sexist, racist, imperial science.
Social factors of procrastination: group work can reduce procrastination among students
Authors: Koppenborg Markus , Klingsieck Katrin B.
Published: January 2022

Research on procrastination covers a variety of individual factors (e.g., conscientiousness) and this focus is reflected in interventions against procrastination. Less emphasis is put on situational and social factors that may help students reduce procrastination, such as social interdependence. Therefore, this study investigates the relationship between interdependence with academic procrastination and affective variables. Two vignette studies with student samples (N1 = 320,N2 = 193) were conducted and data was analyzed with regression analyses and analyses of covariance. Results of both studies show lower state procrastination in group work with interdependence compared to individual work, especially in participants with high trait procrastination. This difference is more pronounced when interdependence is accompanied by an active commitment to finish the task on time. Further, interdependent group work is related to increased positive affect and decreased negative affect. The results demonstrate the relevance of situational and social factors for academic procrastination, and point toward new approaches for intervention.
Phenomenological Model of Nonlinear Dynamics and Deterministic Chaotic Gas Migration in Bentonite: Experimental Evidence and Diagnostic Parameters
Authors: Faybishenko Boris , Wang Yifeng , Harrington Jon , Tamayo-Mas Elena , Birkholzer Jens , Jové-Colón Carlos
Published: January 2022

Understanding gas migration in compacted clay materials, e.g., bentonite and claystone, is important for the design and performance assessment of an engineered barrier system of a radioactive waste repository system, as well as many practical applications. Existing field and laboratory data on gas migration processes in low-permeability clay materials demonstrate the complexity of flow and transport processes, including various types of instabilities, caused by nonlinear dynamics of coupled processes of liquid–gas exchange, dilation, fracturing, fracture healing, etc., which cannot be described by classical models of fluid dynamics in porous media. We here show that the complexity of gas migration processes can be explained using a phenomenological concept of nonlinear dynamics and deterministic chaos theory. To do so, we analyzed gas pressure and gas influx (i.e., input) and outflux (i.e., output), recorded during the gas injection experiment in the compact Mx80-D bentonite sample, and calculated a set of the diagnostic parameters of nonlinear dynamics and chaos, such a global embedding dimension, a correlation dimension, an information dimension, and a spectrum of Lyapunov exponents, as well as plotted 2D and 3D pseudo-phase-space strange attractors, based on the univariate influx and outflux time series data. These results indicate the presence of phenomena of low-dimensional deterministic chaotic behavior of gas migration in bentonite. In particular, during the onset of gas influx in the bentonite core, before the breakthrough, the development of gas flow pathways is characterized by the process of chaotic gas diffusion. After the breakthrough, with inlet-to-outlet movement of gas, the prevailing process is chaotic advection. During the final phase of the experiment, with no influx to the sample, the relaxation pattern of gas outflux is resumed back to a process of chaotic diffusion. The types of data analysis and a proposed phenomenological model can be used to establish the basic principles of experimental data-gathering, modeling predictions, and a research design.
DExIE - An IoT-Class Hardware Monitor for Real-Time Fine-Grained Control-Flow Integrity
Authors: Spang Christoph , Lavan Yannick , Hartmann Marco , Meisel Florian , Koch Andreas
Published: January 2022

The Dynamic Execution Integrity Engine (DExIE) is a lightweight hardware monitor that can be flexibly attached to many IoT-class processor pipelines. It is guaranteed to catch both inter- and intra-function illegal control flows in time to prevent any illegal instructions from touching memory. The performance impact of attaching DExIE to a core depends on the concrete pipeline structure. In some especially suitable cases, extending a processor with DExIE will have no performance penalty. DExIE is real-time capable, as it causes no or only up to 10.4 % additional and then predictable pipeline stalls. Depending on the monitored processor’s size and structure, DExIE is faster than software-based monitoring and often smaller than a separate guard processor. We present not just the hardware architecture, but also the automated programming flow, and discuss compact adaptable storage formats to hold fine-grained control flow information.
Evaluating the aerobic xylene-degrading potential of the intrinsic microbial community of a legacy BTEX-contaminated aquifer by enrichment culturing coupled with multi-omics analysis: uncovering the role of Hydrogenophaga strains in xylene degradation
Authors: Banerjee Sinchan , Bedics Anna , Harkai Péter , Kriszt Balázs , Alpula Nagaraju , Táncsics András
Published: January 2022

To develop effective bioremediation strategies, it is always important to explore autochthonous microbial community diversity using substrate-specific enrichment. The primary objective of this present study was to reveal the diversity of aerobic xylene-degrading bacteria at a legacy BTEX-contaminated site where xylene is the predominant contaminant, as well as to identify potential indigenous strains that could effectively degrade xylenes, in order to better understand the underlying facts about xylene degradation using a multi-omics approach. Henceforward, parallel aerobic microcosms were set up using different xylene isomers as the sole carbon source to investigate evolved bacterial communities using both culture-dependent and independent methods. Research outcome showed that the autochthonous community of this legacy BTEX-contaminated site has the capability to remove all of the xylene isomers from the environment aerobically employing different bacterial groups for different xylene isomers. Interestingly, polyphasic analysis of the enrichments disclose that the community composition of the o-xylene-degrading enrichment community was utterly distinct from that of the m- and p-xylene-degrading enrichments. Although in each of the enrichments Pseudomonas and Acidovorax were the dominant genera, in the case of o-xylene-degrading enrichment Rhodococcus was the main player. Among the isolates, two Hydogenophaga strains, belonging to the same genomic species, were obtained from p-xylene-degrading enrichment, substantially able to degrade aromatic hydrocarbons including xylene isomers aerobically. Comparative whole-genome analysis of the strains revealed different genomic adaptations to aromatic hydrocarbon degradation, providing an explanation on their different xylene isomer-degrading abilities.
Sources of airborne particulate matter-bound metals and spatial-seasonal variability of health risk potentials in four large cities, South Korea
Authors: Choi Eunhwa , Yi Seung-Muk , Lee Young Su , Jo Hyeri , Baek Sung-Ok , Heo Jong-Bae
Published: January 2022

Fifteen airborne particulate matter-bound metals were analyzed at 14 sites in four large cities (Seoul, Incheon, Busan, Daegu) in South Korea, between August 2013 and June 2017. Among the seven sources resolved by positive matrix factorization, soil dust and marine aerosol accounted for the largest and second largest portions in the three cities; however, in Seoul, soil dust and traffic occupied the largest and the second largest, respectively. Non-carcinogenic risk assessed by inhalation of eight metals (Cd, Co, Ni, Pb, As, Al, Mn, and V) was greater than the hazard index (HI) of 1 at four sites located at or near the industrial complexes. Cumulative incremental lifetime cancer risk (ILCR) due to exposure to five metals (Cd, Co, Ni, Pb, and As) exceeded the 10−6 cancer benchmark at 14 sites and 10−5 at six sites, which includes four sites with HI greater than 1. The largest contributor to ILCR was coal combustion in Seoul, Incheon, and Daegu, and industry sources in Busan. Moreover, industry sources were the largest contributors to non-carcinogenic risk in Seoul, Busan, and Daegu, and soil dust was in Incheon. Incheon had the highest HI in spring because of the higher contribution of soil dust sources than in other seasons. The higher ILCR in Incheon in spring and winter and higher ILCR and HI in Daegu in autumn were mainly due to the influence of industry or coal combustion sources. Statistically significant differences in the ILCR and HI values among the sampling sites in Busan and Daegu resulted from the higher contribution of industry sources at a certain site in the respective city.
Patient Perspectives on Improving Patient-Provider Relationships and Provider Communication During Opioid Tapering
Authors: Kosakowski Sarah , Benintendi Allyn , Lagisetty Pooja , Larochelle Marc R. , Bohnert Amy S. B. , Bazzi Angela R.
Published: January 2022

Background

Efforts to reduce opioid overdose fatalities have resulted in tapering (i.e., reducing or discontinuing) opioid prescriptions despite a limited understanding of patients’ experiences.

Objective

To explore patients’ perspectives on opioid taper experiences to ultimately improve taper processes and outcomes.

Design

Qualitative study.

Participants

Patients on long-term opioid therapy for chronic pain who had undergone a reduction of opioid daily prescribed dosage of ≥50% in the past 2 years in two distinct medical systems and regions.

Approach

From 2019 to 2020, we conducted semi-structured interviews that were audio-recorded, transcribed, systematically coded, and analyzed to summarize the content and identify key themes regarding taper experiences overall and with particular attention to patient-provider relationships and provider communication during tapers.

Key Results

Participants (n=41) had lived with chronic pain for an average of 17.4 years (range, 3–36 years) and described generally adverse experiences with opioid tapers, the initiation of which was not always adequately justified or explained to them. Consequences of tapers ranged from minor to substantial and included withdrawal, mobility issues, emotional distress, exacerbated mental health symptoms, and feelings of social stigmatization for which adequate supports were typically unavailable. Narratives highlighted the consequential role of patient-provider relationships throughout taper experiences, with most participants describing significant interpersonal challenges including poor provider communication and limited patient engagement in decision making. A few participants identified qualities of providers, relationships, and communication that fostered more positive taper experiences and outcomes.

Conclusions

From patients’ perspectives, opioid tapers can produce significant physical, emotional, and social consequences, sometimes reducing trust and engagement in healthcare. Patient-provider relationships and communication influence patients’ perceptions of the quality and outcomes of opioid tapers. To improve patients’ experiences of opioid tapers, tapering plans should be based on individualized risk-benefit assessments and involve patient-centered approaches and improved provider communication.