bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the role of the complement system, endothelial injury, and microRNAs in thrombotic microangiopathy after kidney transplantation
Authors: Aleš Rigler Andreja , Večerić-Haler Željka , Arnol Miha , Perše Martina , Boštjančič Emanuela , Pleško Jerica , Simčič Saša , Kojc Nika
Published: December 2020

Objective

We investigated whether the recipient’s complement system function, kidney graft endothelial ultrastructural injury, and microRNA (miRNA) expression before transplantation may be associated with the risk of posttransplant de novo thrombotic microangiopathy (TMA).

Methods

Complement system function assessment, histological and ultrastructural examination of preimplantation and kidney graft biopsies, and microRNA assessment were performed on kidney transplant recipients (KTRs) with de novo TMA.

Results

On the basis of the clinical course, histological findings, and miRNA patterns, the following two de novo TMA phenotypes were observed: a self-limiting disease that was localized to the kidney graft and a systemic disease that progressed to graft failure without timely treatment. Decreased alternative complement pathway activity and ultrastructural endothelial injury before transplantation were confirmed in all five KTRs and four of five KTRs, respectively, but they did not correlate with de novo TMA severity.

Conclusions

Alternative complement pathway abnormalities in KTRs and endothelial ultrastructural injury on preimplantation biopsy might be associated with de novo posttransplant TMA, although they did not predict posttransplant TMA severity (localized vs. systemic). The specific miRNA expression patterns in preimplantation kidney graft biopsies demonstrated a borderline statistically significant difference and might provide more accurate information on posttransplant TMA severity.
Mitotic Figures—Normal, Atypical, and Imposters: A Guide to Identification
Authors: Donovan Taryn A. , Moore Frances M. , Bertram Christof A. , Luong Richard , Bolfa Pompei , Klopfleisch Robert , Tvedten Harold , Salas Elisa N. , Whitley Derick B. , Aubreville Marc , Meuten Donald J.
Published: December 2020

Counting mitotic figures (MF) in hematoxylin and eosin–stained histologic sections is an integral part of the diagnostic pathologist’s tumor evaluation. The mitotic count (MC) is used alone or as part of a grading scheme for assessment of prognosis and clinical decisions. Determining MCs is subjective, somewhat laborious, and has interobserver variation. Proposals for standardizing this parameter in the veterinary field are limited to terminology (use of the term MC) and area (MC is counted in an area measuring 2.37 mm2). Digital imaging techniques are now commonplace and widely used among veterinary pathologists, and field of view area can be easily calculated with digital imaging software. In addition to standardizing the methods of counting MF, the morphologic characteristics of MF and distinguishing atypical mitotic figures (AMF) versus mitotic-like figures (MLF) need to be defined. This article provides morphologic criteria for MF identification and for distinguishing normal phases of MF from AMF and MLF. Pertinent features of digital microscopy and application of computational pathology (CPATH) methods are discussed. Correct identification of MF will improve MC consistency, reproducibility, and accuracy obtained from manual (glass slide or whole-slide imaging) and CPATH approaches.
Measures of anticoagulation and coagulopathy in pediatric cardiac extracorporeal membrane oxygenation patients
Authors: Yabrodi Mouhammad , Ciccotello Carrie , Bhatia Ajay K , Davis Joel , Maher Kevin O , Deshpande Shriprasad R
Published: December 2020

Introduction:

Pediatric cardiac Extracorporeal Membrane Oxygenation (ECMO) is effective, however, bleeding and clotting issues continue to cause significant morbidity and mortality. The objective of this study was to assess the correlation between measures of anticoagulation, the heparin dose in pediatric cardiac ECMO patients as well as to assess covert coagulopathy as measured by thromboelastography (TEG).

Methods:

Retrospective study of cardiac ECMO patients in a large, academic referral center using anticoagulation data during the ECMO support.

Results:

Five hundred and eighty-four sets of anticoagulation tests and 343 TEG from 100 patients with median age of 26 days were reviewed. ECMO was post-surgical for congenital heart disease in 94% with resuscitation (ECPR) in 38% of the cases. Mean duration of support was 6.3 days. Overall survival to discharge was 35%. There was low but statistically significant correlation between individual anticoagulation measures and low correlation between Anti-Xa levels and heparin dose. There was no correlation between PTT and heparin dose. 343 TEG with Heparinase were reviewed to assess covert coagulopathy which was present in 25% of these. The coagulopathy noted was pro-hemorrhagic in almost all of the cases with high values of reaction time and kinetics and low values for angle and maximum amplitude.

Conclusion:

Coagulation monitoring on ECMO may benefit from addition of Heparinase TEG to diagnose covert coagulopathy which can contribute to significant hemorrhagic complications. There is a need for a prospective, thromboelastography guided intervention trial to reduce coagulopathy related morbidity and mortality in ECMO.
Marital Quality and Salivary Telomere Length Among Older Men and Women in the United States
Authors: Yu Yan-Liang , Liu Hui
Published: December 2020

Objective: The link between marital quality and cellular aging remains underexplored. This study examined how both positive and negative marital quality were associated with salivary telomere length among partnered adults in the United States over the age of 50°years. Methods: Data were from the 2008 Health and Retirement Study ( N = 3203). Ordinary least squares regression was used to estimate the link between marital quality and telomere length. Results: While neither positive nor negative marital quality was significantly associated with telomere length among older women, positive and negative marital quality had an interacting effect on telomere length among men. Specifically, when negative marital quality was low, higher positive marital quality was associated with shorter telomere length, whereas when negative marital quality was high, higher positive marital quality was associated with longer telomere length. Discussion: The findings speak to the complex nature of intimate partnerships and the implications of these partnerships for cellular aging processes.
Epitheliotropic T-cell lymphoma in 2 half-sibling bontebok
Authors: Imanse Sierra M. , Monahan Colleen F. , Thompson Kimberly A. , Marrow Judilee C. , Corner Sarah M.
Published: December 2020

We diagnosed epitheliotropic T-cell lymphoma of the forestomachs in 2 aged, half-sibling, zoo-managed bontebok ( Damaliscus pygargus pygargus). One bontebok also had mesenteric lymph node and cutaneous involvement. Both animals had a history of chronic abdominal distension and diminished body condition that resulted in euthanasia. At autopsy, both animals had marked ruminal distension with diffusely blunted ruminal papillae and reticular crests. In case 1, there was an increased amount and particle length of the ruminoreticular fibrous material with scant fluid, and a 2-cm diameter focus of cutaneous crusting adjacent to a mammary teat. In case 2, the rumen and reticulum were fluid-distended with decreased fibrous material. Histologically in case 1, the rumen, reticulum, omasum, and skin had intraepithelial nests and sheets of neoplastic small lymphocytes; in case 2, the rumen and reticulum had a similar neoplastic cell population. Immunohistochemically, neoplastic lymphocytes were immunoreactive for CD3 and negative for CD20, confirming the diagnosis of epitheliotropic T-cell lymphoma.
International Differences in Crime Reporting: A Multilevel Exploration of Burglary Reporting in 35 Countries
Authors: Mendlein Alyssa K.
Published: December 2020

Our knowledge about crime, and the ability to help victims, is only as good as the information that is shared with us. However, crime reporting is known to be variable, and much research has been done to look at factors that influence the decision to report. Few studies, though, have looked at whether, and how, the country context impacts a victim’s decision to report crime. Using data from the International Crime Victims Survey and available data on corruption, income inequality, development, and democracy, this article explores that relationship for burglary reporting in 35 different countries through multilevel models. The results confirm that there is significant variation among countries in terms of burglary reporting. In addition, models that take into account both micro- and macro-level predictors show that country-level crime prevalence, democracy, corruption, and income inequality significantly predict burglary reporting and provide support for using Freda Adler’s conception of “synnomie” and anomie as a theoretical framework for understanding the crime reporting decision internationally. Future research should continue to examine crime reporting decisions cross-nationally, as this research has shown the importance of sample composition and crime type on findings, and test the influence of macro-level factors, especially relating to “synnomie,” over time.
How Other Minorities Gained Access: The War on Poverty and Asian American and Latino Community Organizing
Authors: Kim Jae Yeon
Published: December 2020

In the early twentieth century, Asian Americans and Latinos organized along national origin lines and focused on assimilation; By the 1960s and 1970s, community organizers from both groups began to form panethnic community service organizations (CSOs) that emphasized solidarity. I argue that focusing on the rise of panethnic CSOs reveals an underappreciated mechanism that has mobilized Asian Americans and Latinos—the welfare state. The War on Poverty programs incentivized non-black minority community organizers to form panethnic CSOs to gain access to state resources and serve the economically disadvantaged in their communities. Drawing on extensive archival research, I identify this mechanism and test it with my original dataset of 818 Asian American and Latino advocacy organizations and CSOs. Leveraging the Reagan budget cut, I show that dismantling the War on Poverty programs reduced the founding rate of panethnic CSOs. I further estimated that a 1 percent increase in federal funding was associated with the increase of the two panethnic CSOs during the War on Poverty. The findings demonstrate how access to state resources forces activists among non-primary beneficiary groups to build new political identities that fit the dominant image of the policy beneficiaries.
Evaluating the Instantiation of Narcissism Components in Contemporary Measures of Psychopathy
Authors: Weiss Brandon , Sleep Chelsea E. , Lynam Donald R. , Miller Joshua D.
Published: December 2020

Narcissistic traits figure prominently in classical conceptualizations of psychopathy and bear substantial empirical overlap with components of psychopathy. Yet the degree to which various widely used self-report measures of psychopathy include relevant narcissistic content has not been evaluated, especially in relation to new, multidimensional models of narcissism. Using a large undergraduate sample ( N = 432) and self- and informant-ratings of narcissism, the present study examined narcissism’s instantiation in several commonly used self-report psychopathy measures. A modern conceptualization of narcissism at three levels of hierarchical organization (i.e., Trifurcated Model of Narcissism) was applied to comprehensively evaluate narcissism’s instantiation in these psychopathy measures. Although narcissistic traits related to self-centered antagonism were well-instantiated across psychopathy self-report measures, narcissistic traits related to agentic extraversion were represented more modestly by most (i.e., Triarchic Psychopathy Measure, Self-Report Psychopathy Scale: Version III, Levenson Self-Report Psychopathy Scale), but not all (i.e., Elemental Psychopathy Assessment [EPA]) psychopathy measures. Only the EPA contained substantial representation of all narcissism components. Given the theoretical and empirical overlap between psychopathy and narcissism, it behooves researchers to be aware of the degree to which psychopathy measures capture narcissistic content.
Changes in Coagulation During Twin Pregnancies
Authors: Ren Ke , Wei Yuan , Qiao Rui , Shi Huifeng , Gong Xiaoli , Zhao Yangyu
Published: December 2020

To investigate changes in coagulation during twin pregnancies. Methods: A total of 108 women with twin pregnancies and 442 women with singleton pregnancies were recruited. Coagulation tests, including fibrinogen (Fib), activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT), were performed during the course of the pregnancy. The level of fibrinogen gradually increased during singleton pregnancies, while the APTT and PT levels showed a decreasing trend with increasing gestational weeks. In twin pregnancies, the changes in PT and TT were similar, but other parameters displayed a different trend. Fibrinogen showed no significant difference between the second and third trimesters, while APTT showed an increasing trend from the second trimester to the third trimester. Compared with singleton pregnancies, the level of fibrinogen was higher in women pregnant with twins. APTT was longer in women pregnant with twins than in women with singleton pregnancies in the third trimester. PT was shorter in women pregnant with twins than in women with singleton pregnancies in the first and third trimesters. TT was shorter in women pregnant with twins than in women with singleton pregnancies in the first and second trimesters. Through this retrospective longitudinal analysis, this study presents the main coagulation parameter changes in singleton and twin pregnancies and confirms that coagulation is more enhanced in twin pregnancies than in singleton pregnancies.
Robust control-based disturbance observer and optimal states feedback for T–S fuzzy systems
Authors: Giap Van-Nam , Huang Shyh-Chour , Nguyen Quang D , Su Te-Jen
Published: December 2020

This paper presents a robust control methodology based on a disturbance observer and an optimal states feedback for Takagi–Sugeno fuzzy system. Firstly, the nonlinear systems were solved by applying a sector nonlinearity method to get the inner linear subsystems and outer fuzzy membership functions, which guaranteed the conversion without any loss generality characteristics of the system. Secondly, an exponentially convergent disturbance observer was constructed to the system with an assumption that the system states are temporarily bounded. Thirdly, a states observer was built by poles placement of linear quadratic regulation optimization, which was used to place the system states error poles located on the stable region. Finally, simulation examples were given to figure out that the proposed controller is effective to control the Takagi–Sugeno fuzzy system. The obtained results are disturbance mostly rejected, state estimation errors are quite small, and the output signal precisely tracked input signal.
Interviewing the Interviewers: Perceptions of Interviewer–Respondent Familiarity on Survey Process and Error in Burkina Faso
Authors: Greenleaf Abigail R. , Turke Shani R. , Bazié Fiacre , Sawadogo Nathalie , Guiella Georges , Moreau Caroline
Published: December 2020

A growing body of literature in low- and middle-income countries is challenging the long-held assumption that the respondent and interviewer should be strangers. We conducted a qualitative study in Burkina Faso comprised of in-depth interviews and focus group discussions to explore interviewers’ experiences of collecting data on sexual and reproductive health indicators in their communities, and their perceptions of how familiarity with the respondents influences measurement error and nonresponse. We found that interviewers perceive familiarity to affect the process of collecting data but has minimal impact on responses obtained. Rather, interviewers perceived the personality of the respondent and her willingness to disclose personal information to be of greater influence. This study illustrates the complexities of interviewer–respondent exchange, provides context for the hiring practices of future surveys, and suggests specific variables to check when assessing data quality.
Electromagnetic wave shielding and mechanical properties of vapor-grown carbon nanofiber/polyvinylidene fluoride composite fibers
Authors: Yuksek Metin
Published: December 2020

The demand for multifunctional requirements in aerospace, military, automobile, sports, and energy applications has encouraged the investigation of new conductive composite fibers. This study focuses on the development of Vapor-grown carbon nanofibers (VGCNFs) filled Polyvinylidene Fluoride (PVDF) composite fibers. Polyvinylidene fluoride (PVDF) reinforced with (1, 3, 5, and 8 wt.%) carbon nanofibers were produced as a masterbatch. The production of PVDF and PVDF/CNF composite fibers have been done successfully by using melt spinning processing technique. Conductive woven fabrics were produced with composite fibers on handloom machines to measure electromagnetic interference (EMI) shielding efficiency. Tensile strength of fibers increased with increase in CNF loading up to 3%. The tensile strength displayed a decrease of 5% and 8% CNF loading. Electromagnetic shielding effectiveness (EMSE) of woven fabrics with composite fibers were tested by using the coaxial transmission line method for planar materials standard that is based on ASTM D 4935-10. The electromagnetic shielding effectiveness of woven fabric which is consist of conductive composite fibers were increased with increasing CNFs loading and amount of fabric layers. It can be seen that the woven fabrics displayed between 2–10 dB and 2–4 dB EMSE values in the 15–600 MHz and 600–3000 MHz-frequency range, respectively. Nevertheless, it was observed that conductive filler content, dispersion, and network formation within the composite fibers were highly influent on the electromagnetic shielding effectiveness performance of the structures.
Adherence to COREQ Reporting Guidelines for Qualitative Research: A Scientometric Study in Nursing Social Science
Authors: Walsh Sandra , Jones Martin , Bressington Dan , McKenna Lisa , Brown Ellie , Terhaag Sonia , Shrestha Monika , Al-Ghareeb Amal , Gray Richard
Published: December 2020

Qualitative research plays an important role in helping us describe, interpret and generate theories about complex phenomena in healthcare. Complete and transparent reporting of research informs readers about the significance and rigor of the work. The aim of this scientometric study was to determine the quality of reporting of qualitative research in nursing social science. Studies were identified by manually searching the table of contents for qualitative papers published in the June (or closest subsequent) 2018 issue of 115 nursing journals. Adherence with the 32-item Consolidated Criteria for REporting Qualitative (COREQ) research was determined for each study by two researchers. Additional information about the study (e.g., sample size, field of nursing) and the publishing journal (e.g., endorsement of COREQ) were also extracted. Using established criteria, COREQ compliance was coded either good (≥ 25 items), moderate (17 to 24), poor (9 to 16), very poor (≤ 8) based on the number of items addressed in each study. One hundred and ninety-seven manuscripts were included. The quality of reporting was generally rated as either moderate (57%) or poor (38%). Journal endorsement of qualitative reporting guidelines was associated with better reporting. The reporting of qualitative research in nursing social science journals is suboptimal. Researchers, authors, reviewers and journal editors need to ensure their papers comprehensively address the requirements of COREQ to ensure comprehensive and transparent reporting of their research.
Study on vertical motion reduction of a trimaran based on collaborative controlled appendages
Authors: Liu Zhilin , Zheng Linhe , Li Guosheng , Yuan Shouzheng , Yang Songbai
Published: December 2020

In recent years, the trimaran as a novel ship has been greatly developed. The subsequent large vertical motion needs to be studied and resolved. In this article, an experimental study for a trimaran vertical stabilization control is carried out. Three modes including the bare trimaran (the trimaran without appendages, the trimaran with fixed appendages, and the trimaran with controlled appendages) are performed through model tests in a towing tank. The model tests are performed in regular waves. The range of wave period is 2.0–4.0 s, and the speed of the carriage is 2.93 and 6.51 m/s. The results of the three modes show the fixed appendages and the actively controlled appendages are all effective for the vertical motion reduction of the trimaran. Moreover, the controlled appendages are more effective for the vertical stability performance of the trimaran.
Alkaloids and flavonoids from African phytochemicals as potential inhibitors of SARS-Cov-2 RNA-dependent RNA polymerase: anin silicoperspective
Authors: Ogunyemi Oludare M , Gyebi Gideon A , Elfiky Abdo A , Afolabi Saheed O , Ogunro Olalekan B , Adegunloye Adegbenro P , Ibrahim Ibrahim M
Published: December 2020

Corona Virus Disease 2019 (COVID-19) is a pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Exploiting the potentials of phytocompounds is an integral component of the international response to this pandemic. In this study, a virtual screening through molecular docking analysis was used to screen a total of 226 bioactive compounds from African herbs and medicinal plants for direct interactions with SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). From these, 36 phytocompounds with binding affinities higher than the approved reference drugs (remdesivir and sobosivir), were further docked targeting the active sites of SARS-CoV-2, as well as SARS-CoV and HCV RdRp. A hit list of 7 compounds alongside two positive controls (remdesivir and sofosbuvir) and two negative controls (cinnamaldehyde and Thymoquinone) were further docked into the active site of 8 different conformations of SARS-CoV-2 RdRp gotten from molecular dynamics simulation (MDS) system equilibration. The top docked compounds were further subjected to predictive druglikeness and ADME/tox filtering analyses. Drugable alkaloids (10’–hydroxyusambarensine, cryptospirolepine, strychnopentamine) and flavonoids (usararotenoid A, and 12α-epi-millettosin), were reported to exhibit strong affinity binding and interactions with key amino acid residues in the catalytic site, the divalent-cation–binding site, and the NTP entry channel in the active region of the RdRp enzyme as the positive controls. These phytochemicals, in addition to other promising antivirals such as remdesivir and sofosbuvir, may be exploited towards the development of a cocktail of anti-coronavirus treatments in COVID-19. Experimental studies are recommended to validate these study.
Strong-axis response of steel I-sections subjected to close-in detonations
Authors: Grisaro Hezi Y , Seica Michael V , Packer Jeffrey A , Li Wei
Published: December 2020

The analysis of structural members subjected to close-in detonations involves a complicated dynamic scenario. Since the charge is very close to the structural member, the reflected pressure distribution on the member surface is highly non-uniform. In addition, the level of damage to the structural member may be high because of the large magnitude of the load. Due to these phenomena, the response of a structural member to close-in detonation cannot be accurately modelled by relatively simple methods like single-degree of freedom models, and more complicated models are required. Such models need to include numerical simulation of the detonation process, which produces a non-uniform pressure environment, allowing the pressure to reflect and flow around the member section. The local damage and flow around the section are especially of interest in I-shaped, or wide-flange-section members. Herein, the response of such sections is modelled by numerical simulations using a novel technique, which overcomes the difficulty of computation time, and is validated through various calculations. The model is used to perform a parametric study to investigate the response of I-sections subjected to close-in detonations, in terms of local damage and global behaviour, with scaled distances of 0.15–0.29 m/kg1/3 and loading causing flexure about the strong axis. Various aspects that affect the performance are studied, such as: the effect of scaled distance, the addition of welded stiffening plates between the flanges and web, the effect of boundary conditions and the effect of charge shape. Resulting local damage and residual deformations are assessed for the cases studied.
Treatment of acne and acne-related scarring with fixed combination clindamycin phosphate and benzoyl peroxide gel (1.2%/3.75%) and tretinoin gel microsphere 0.06% in an Asian American transgender female
Authors: Kaminska Edidiong CN
Published: December 2020

Acne vulgaris is one of the most common skin diseases in the United States and can affect any gender or ethnic group. Post-inflammatory hyperpigmentation (PIH) and scarring from acne can have a negative psychosocial impact on patients. Skin of color patients are particularly prone to PIH, as the dark marks left from acne may take several months to resolve, far after the acne has cleared. Here, we report a case of moderate acne with associated scarring in a transgender, Asian American female who was successfully treated with fixed combination topical therapy with clindamycin phosphate and benzoyl peroxide gel 1.2%/3.75% and tretinoin gel microsphere 0.06%.
‘Cannabis’ ontologies I: Conceptual issues with Cannabis and cannabinoids terminology
Authors: Riboulet-Zemouli Kenzi
Published: December 2020

Objective

Identify a coherent nomenclature for Cannabis sativa L. derived products and their analogues.

Design

Research undertaken in parallel to the three-year assessment of Cannabis derivatives by the World Health Organisation. The scope is limited to Cannabis products intended for human incorporation (internal and topical consumption). Primarily embedded in pharmacognosy, the study incorporates a wide range of scholarly and grey literature, folk knowledge, archives, pharmacopœias, international law, field pharmacy, clinical and herbal medicine data, under a philosophical scrutiny. Generic and Cannabis-specific nomenclatural frames are compared to determine the extent to which they coincide or conflict.

Results

All lexica reviewed use weak, ambiguous, or inconsistent terms. There is insufficient scientific basis for terms and concepts related to Cannabis at all levels. No sound classification exists: current models conflict by adopting idiosyncratic, partial, outdated, or utilitarian schemes to arrange the extraordinarily numerous and diverse derivatives of the C. sativa plant. In law and policy, no clear or unequivocal boundary between herbal and non-herbal drugs, nor natural and synthetic cannabinoids was found; current nomenclatures need updates. In science, the botanical Cannabis lexicon overlooks parthenocarpy, and wide disagreement remains as to the taxonomy and systematics of the plant; chemical research should address differences in kinds between synthetic cannabinoids; pharmacopœias include little information related to Cannabis, and disagree on broader classes of herbal medicines, virtually failing to embrace many known Cannabis medicines. Since existing products and compounds fail to be categorised in an evidence-based manner, confusions will likely increase as novel cannabinoid compounds, genetic and biotechnological modifications surge.

Conclusions

The lack of clarity is comprehensive: for patients, physicians, and regulators. This study proposes an update of terms at several levels. It points at gaps in morphological descriptions in botany and pharmacognosy and a need for a metaphysical address of cannabinoids. Methods of obtention are identified as a common criterion to distinguish products; the way forward suggests a mutually exclusive nomenclatural pattern based on the smallest common denominator of obtention methods. In the context of a swelling number of Cannabis products being consumed (be it via medical prescription, adult-use, ‘hemp’ foodstuff and cosmetics, or other purposes), this study can assist research, contribute to transparent labelling of products, consumer safety and awareness, pharmacovigilance, medical standards of care, and an update of prevention and harm reduction approaches. It can also better inform regulatory policies surrounding C. sativa, its derivatives, and other cannabinoid-containing products.
Too Cool? Hip Fracture Care and Maintaining Body Temperature
Authors: Arkley James , Taher Suhib , Dixon Ján , Dietz-Collin Gemma , Wales Stacey , Wilson Faye , Eardley William
Published: December 2020

Introduction:

Patients with hip fractures can become cold during the perioperative period despite measures applied to maintain warmth. Poor temperature control is linked with increasing complications and poorer functional outcomes. There is generic evidence for the benefits of maintaining normothermia, however this is sparse where specifically concerning hip fracture. We provide the first comprehensive review in this population.

Significance:

Large studies have revealed dramatic impact on wound infection, transfusion rates, increased morbidity and mortality. With very few studies relating to hip fracture patients, this review aimed to capture an overview of available literature regarding hypothermia and its impact on outcomes.

Results:

Increased mortality, readmission rates and surgical site infections are all associated with poor temperature control. This is more profound, and more common, in older frail patients. Increasing age and lower BMI were recognized as demographic factors that increase risk of hypothermia, which was routinely identified within modern day practice despite the use of active warming.

Conclusion:

There is a gap in research related to fragility fractures and how hypothermia impacts outcomes. Inadvertent intraoperative hypothermia still occurs routinely, even when active warming and cotton blankets are applied. No studies documented temperature readings postoperatively once patients had been returned to the ward. This is a point in the timeline where patients could be hypothermic. More studies need to be performed relating to this area of surgery.
Trends in the Treatment of Biceps Pathology: An Analysis of the American Board of Orthopaedic Surgery Database
Authors: Belk John W. , Jones Steven D. , Thon Stephen G. , Frank Rachel M.
Published: December 2020

Background:

Long head of biceps tendon pathology is a well-described source of pain in the anterior adult shoulder. Shoulder arthroscopic surgeons face this condition on a frequent basis because of the increasing aging population. Trends in treatment for this condition have varied over recent decades. An understanding of these trends may help orthopaedic surgeons counsel these patients.

Purpose:

To evaluate trends in treatment selection, patient population, and complications in recent part II examinees of the American Board of Orthopaedic Surgery (ABOS) board examination.

Study Design:

Cross-sectional study.

Methods:

Using a database maintained by the ABOS, we accessed and analyzed examinee data from 2008 to 2019 to evaluate trends in the following categories: examination year/subspecialty, region, patient age/sex, International Classification of Diseases code, Current Procedural Terminology code, and complications. These data points were analyzed for all board-eligible candidates from 2008 to 2019.

Results:

The annual number of proximal biceps tendon (PBT) procedures performed increased significantly from 597 cases in 2008 to 2203 cases in 2019 ( P < .001). Incidence of biceps tendon tenotomy significantly decreased between the years 2007 and 2018 ( P < .001). Both open and arthroscopic biceps tenodesis significantly increased between 2007 and 2018 ( P < .001). Most PBT cases were performed simultaneously with other procedures (17,283/17,861; 96.8%). The most common PBT procedure performed overall was open tenodesis of long tendon of biceps (∼60.8%). Complication rates for PBT procedures reported each year did not significantly change between 2007 and 2018 (7.5% vs 9.7%; P = .103).

Conclusion:

PBT procedures are being increasingly performed among recently trained orthopaedic surgeons. Proximal biceps tenotomy has significantly declined, whereas proximal biceps tenodesis, open or arthroscopic, has significantly increased, demonstrating a possible shift in the standard of care among new surgeons.
Research on the Anterolateral Ligament of the Knee: An Evaluation of PubMed Articles From 2010 to 2019
Authors: Santoso Asep , Anwar Iwan Budiwan , Sibarani Tangkas , Soetjahjo Bintang , Utomo Dwikora Novembri , Mustamsir Edi , Budhiparama Nicolaas C.
Published: December 2020

Background:

The anterolateral ligament (ALL) of the knee remains a topic of interest. All aspects of the ligament, including its anatomy, biomechanics, imaging, and clinical importance, are areas for research among knee surgeons.

Purpose:

To evaluate the trends in research on the ALL of the knee, as indicated by studies indexed in PubMed from 2010 to 2019.

Study Design:

Cross-sectional study.

Methods:

We searched PubMed for article titles from January 1, 2010, to December 31, 2019, that included the term “anterolateral ligament.” The initial search was performed with the terms “anterolateral ligament AND knee” and “anterolateral ligament NOT knee.” Next, we performed a search using “anterolateral complex OR anterolateral reconstruction OR lateral extra-articular tenodesis” to avoid missing any studies. A bibliometric evaluation was performed for the search results, and we noted the characteristics of the most cited articles in PubMed.

Results:

Published studies on the ALL peaked in 2017, with 56 studies, and then declined from 2017 to 2019. The 3 leading journals with articles on the ALL were Arthroscopy; Knee Surgery, Sports Traumatology, Arthroscopy; and The American Journal of Sports Medicine. Cadaveric anatomic, cadaveric biomechanical, and clinical imaging studies of the ALL were the most common types of studies published from 2010 to 2019. Clinical studies on the ALL consisted of 18 articles, with the majority displaying a low level of evidence.

Conclusion:

Cadaveric anatomic/histological, cadaveric biomechanical, and clinical imaging studies of the ALL were the most commonly published studies from 2010 to 2019. More clinical outcome studies with a high level of evidence are needed to increase the supporting data for the future practice of ALL reconstruction.
Does Parental Report of Having a Medical Home Attenuate the Negative Association Between Unmet Basic Needs and Health for Low-Income Children?
Authors: Webb Rebecca , Whitham Anna , Tripodis Yorghos , Long Webb E. , Garg Arvin
Published: December 2020

Background. It is unknown whether the medical home reduces the impact of adverse social determinants on low-income child health. Objective. To examine whether the medical home attenuates the association between unmet basic needs and health for low-income children. Design/Methods. Secondary data analysis of the 2011-12 NSCH restricted to <200% FPL children (n = 26 974). Multivariable logistic regression modeled child health with unmet basic needs to examine the effect modification of the medical home. Results. Low-income children with unmet needs had lower odds of “excellent/very good” health compared to children without unmet needs, regardless of the medical home [aOR = 0.78 (0.61-0.99) vs aOR = 0.77 (0.63-0.94), P = .01), respectively]. The medical home did not modify the negative association between unmet basic needs and “excellent/very good” child health ( P = .97). Conclusion. Having a medical home per parental report did not attenuate the negative relationship between unmet basic needs and lowincome child health.
Providing Legal Education for Medical Students in Arab Gulf Cooperation Council Countries
Authors: Al-Azri Nasser Hammad
Published: December 2020

Law and medicine share an interest in the human body in terms of justice, well-being, and the preservation of physical integrity. Despite the long-lasting relationship between medicine and law, the tension between the two disciplines remains an unresolved issue; each requires the other, and almost all societies require them both. Therefore, there is a need to bring these two disciplines closer to render them more beneficial for society. This article addresses the need to introduce a medical law curriculum in medical schools, specifically in the Arab Gulf Cooperation Council (GCC) countries. This article first illustrates the relationship between law and medicine by defining the discipline of medical law. Thereafter, it makes a case for including a medical law curriculum in medical school and health care education programs in GCC countries, illustrating the benefits of doing so for society, individuals, and the development of the disciplines themselves. Subsequently, this article proposes an outline for a spiral and integrated medical law curriculum based on the needs and values of GCC countries. This outline is centered around the basic and advanced core topics and encourages engagement with law-medicine activities that further bridge the conceptual gap between medicine and law. This article reasserts the need to bring medicine and law closer together for the benefit of society and the development of the disciplines. One crucial way of doing so is providing formal and structured legal education for medical students.
Dynamic changes in murine erythropoiesis from birth to adulthood: implications for the study of murine models of anemia
Authors: Chen Lixiang , Wang Jie , Liu Jing , Wang Hua , Hillyer Christopher D. , Blanc Lionel , An Xiuli , Mohandas Narla
Published: December 2020

Liver, spleen, and bone marrow are 3 key erythropoietic tissues in mammals. In the mouse, the liver is the predominant site of erythropoiesis during fetal development, the spleen responds to stress erythropoiesis, and the bone marrow is involved in maintaining homeostatic erythropoiesis in adults. However, the dynamic changes and respective contributions of the erythropoietic activity of these tissues from birth to adulthood are incompletely defined. Using C57BL/6 mice, we systematically examined the age-dependent changes in liver, spleen, and bone marrow erythropoiesis following birth. In addition to bone marrow, the liver and spleen of newborn mice sustain an active erythropoietic activity that is gradually lost during first few weeks of life. While the erythropoietic activity of the liver is lost 1 week after birth, that of the spleen is maintained for 7 weeks until the erythropoietic activity of the bone marrow is sufficient to sustain steady-state adult erythropoiesis. Measurement of the red cell parameters demonstrates that these postnatal dynamic changes are reflected by varying indices of circulating red cells. While the red cell numbers, hemoglobin concentration, and hematocrit progressively increase after birth and reach steady-state levels by week 7, reticulocyte counts decrease during this time period. Mean cell volume and mean cell hemoglobin progressively decrease and reach steady state by week 3. Our findings provide comprehensive insights into developmental changes of murine erythropoiesis postnatally and have significant implications for the appropriate interpretation of findings from the variety of murine models used in the study of normal and disordered erythropoiesis.
Prognostic value and co-expression patterns of metabolic pathways in cancers
Authors: Zhang Dan , Guo Yan , Xie Ni
Published: December 2020

Background

Abnormal metabolic pathways have been considered as one of the hallmarks of cancer. While numerous metabolic pathways have been studied in various cancers, the direct link between metabolic pathway gene expression and cancer prognosis has not been established.

Results

Using two recently developed bioinformatics analysis methods, we evaluated the prognosis potential of metabolic pathway expression and tumor-vs-normal dysregulations for up to 29 metabolic pathways in 33 cancer types. Results show that increased metabolic gene expression within tumors corresponds to poor cancer prognosis. Meta differential co-expression analysis identified four metabolic pathways with significant global co-expression network disturbance between tumor and normal samples. Differential expression analysis of metabolic pathways also demonstrated strong gene expression disturbance between paired tumor and normal samples.

Conclusion

Taken together, these results strongly suggested that metabolic pathway gene expressions are disturbed after tumorigenesis. Within tumors, many metabolic pathways are upregulated for tumor cells to activate corresponding metabolisms to sustain the required energy for cell division.
Multivariate genome wide association and network analysis of subcortical imaging phenotypes in Alzheimer’s disease
Authors:   for the Alzheimer’s Disease Neuroimaging Initiative, Meng Xianglian , Li Jin , Zhang Qiushi , Chen Feng , Bian Chenyuan , Yao Xiaohui , Yan Jingwen , Xu Zhe , Risacher Shannon L. , Saykin Andrew J. , Liang Hong , Shen Li
Published: December 2020

Background

Genome-wide association studies (GWAS) have identified many individual genes associated with brain imaging quantitative traits (QTs) in Alzheimer’s disease (AD). However single marker level association discovery may not be able to address the underlying biological interactions with disease mechanism.

Results

In this paper, we used the MGAS (Multivariate Gene-based Association test by extended Simes procedure) tool to perform multivariate GWAS on eight AD-relevant subcortical imaging measures. We conducted multiple iPINBPA (integrative Protein-Interaction-Network-Based Pathway Analysis) network analyses on MGAS findings using protein-protein interaction (PPI) data, and identified five Consensus Modules (CMs) from the PPI network. Functional annotation and network analysis were performed on the identified CMs. The MGAS yielded significant hits within APOE, TOMM40 and APOC1 genes, which were known AD risk factors, as well as a few new genes such as LAMA1, XYLB, HSD17B7P2, and NPEPL1. The identified five CMs were enriched by biological processes related to disorders such as Alzheimer’s disease, Legionellosis, Pertussis, and Serotonergic synapse.

Conclusions

The statistical power of coupling MGAS with iPINBPA was higher than traditional GWAS method, and yielded new findings that were missed by GWAS. This study provides novel insights into the molecular mechanism of Alzheimer’s Disease and will be of value to novel gene discovery and functional genomic studies.
The situation of elderly with cognitive impairment living at home during lockdown in the Corona-pandemic in Germany
Authors: Thyrian Jochen René , Kracht Friederike , Nikelski Angela , Boekholt Melanie , Schumacher-Schönert Fanny , Rädke Anika , Michalowsky Bernhard , Vollmar Horst Christian , Hoffmann Wolfgang , Rodriguez Francisca S. , Kreisel Stefan H.
Published: December 2020

Background

The outbreak of the Corona virus is a challenge for health care systems worldwide. The aim of this study is to analyze a) knowledge about, and feelings related to the Corona-pandemic. Describe b) loneliness, depression and anxiety and, c) the perceived, immediate impact of the lockdown on frequency of social contacts and quality of health care provision of people with cognitive impairment during social distancing and lockdown in the primary care system and living at home in Germany.

Methods

This analysis is based on data of a telephone-based assessment in a convenience sample ofn = 141 people with known cognitive impairment in the primary care setting. Data on e.g. cognitive and psychological status prior to the pandemic was available. Attitudes, knowledge about and perceived personal impact of the pandemic, social support, loneliness, anxiety, depression, change in the frequency of social activities due to the pandemic and perceived impact of the pandemic on health care related services were assessed during the time of lockdown.

Results

The vast majority of participants are sufficiently informed about Corona (85%) and most think that the measures taken are appropriate (64%). A total of 11% shows one main symptom of a depression according to DSM-5. The frequency of depressive symptoms has not increased between the time before pandemic and lockdown in almost all participants. The sample shows minimal (65.0%) or low symptoms of anxiety (25%). The prevalence of loneliness is 10%. On average seven activities have decreased in frequency due to the pandemic. Social activities related to meeting people, dancing or visiting birthdays have decreased significantly. Talking with friends by phone and activities like gardening have increased. Utilization of health care services like day clinics, relief services and prescribed therapies have been reported to have worsened due to the pandemic. Visits to general practitioners decreased.

Conclusions

The study shows a small impact of the pandemic on psychological variables like depression, anxiety and loneliness in the short-term in Germany. There is a decrease in social activities as expected. The impact on health care provision is prominent. There is a need for qualitative, in-depth studies to further interpret the results.
The immune system view of the coronavirus SARS-CoV-2
Authors: Celardo Ivana , Pace Luigia , Cifaldi Loredana , Gaudio Carlo , Barnaba Vincenzo
Published: December 2020

Knowing the “point of view” of the immune system is essential to understand the characteristic of a pandemic, such as that generated by the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2, responsible for the Coronavirus Disease (COVID)-19. In this review, we will discuss the general host/pathogen interactions dictating protective immune response or immunopathology, addressing the role of immunity or immunopathology in influencing the clinical infection outcome, and debate the potential immunoprophylactic and immunotherapy strategies required to fight the virus infection.
Correction to affiliations
Authors:   Financial Innovation
Published: December 2020

An amendment to this paper has been published and can be accessed via the original article.