bluuebunny/crossref_metadata_2025 huggingface dataset:
Angiomyofibroblastoma férfiban – egy ritka paratesticularis eltérés és irodalmi áttekintés
Authors: Kakuja Flóra , Palásti Péter , Oroszi Márton , Kuthi Levente , Király István Előd , Kincses Zsigmond Tamás , Palkó András , Fejes Zsuzsanna
Published: August 2021

Összefoglaló. A scrotum képalkotó vizsgálóeljárásai közül elsőnek
választandó az ultrahang, mivel könnyen hozzáférhető, szenzitivitása és
specificitása magas. Szerepe kiemelendő mind az intratesticularis eltérések
differenciáldiagnózisában, mind pedig a kevésbé ismert paratesticularis
eltérések esetében. Az urológiai ambulancián egy 56 éves férfi jelentkezett
kivizsgálásra tapintható terime miatt. Ultrahangvizsgálattal paratesticularis
elváltozás látszódott, mely a vizsgálat során az inguinalis csatorna irányába
többször elmozdult. A laesio dignitása nem volt meghatározható, ezért műtéti
eltávolításra került sor. A szövettani vizsgálat a férfiak körében ritkán
előforduló angiomyofibroblastoma diagnózisát véleményezte. A paratesticularis
elváltozások ugyan ritkán fordulnak elő, de a gyakoribb entitások és azok
ultrahangos sajátosságainak ismerete elengedhetetlen a terápia tervezése
szempontjából. Orv Hetil. 2021; 162(34): 1376–1382.

Summary. Ultrasonography is the basic imaging technique for the
evaluation of testicular structures because it is easily accessible and has high
sensitivity and specificity. It plays a significant role in the differential
diagnosis of intratesticular changes, in addition, its role should be emphasised
in rare paratesticular abnormalities. A 56-year-old male presented in the
urology department complaining of a palpable inguinal mass and was referred to
ultrasonography for further evaluation. A scrotal ultrasound was performed, and
it described a mobile paratesticular mass without any specific
characterizations. Therefore the lesion was removed, and the histological
analysis established the diagnosis of angiomyofibroblastoma. Paratesticular
lesions are rare, but it is essential to know the frequent abnormalities and the
corresponding ultrasound findings for planning of treatment. Orv Hetil. 2021;
162(34): 1376–1382.
Dializált betegek életviteli nehézségeinek megismerése kvantitatív vizsgálómódszerekkel
Authors: Mátyás Eszter , Hargitai Rita , Haris Ágnes
Published: August 2021

Összefoglaló.
Bevezetés: A krónikus vesebetegség tünetei, a kezelés
sajátosságai nagymértékben korlátozzák a páciensek mindennapi életvitelét,
hatással vannak testi és lelki egészségükre, és nehezítik társas kapcsolataikat.
Célkitűzések: A jelen kutatás célja a magyar dializált
betegpopuláció egészségműveltségének, életminőségének és betegségterhének
megismerése, továbbá a kezelési típusok hatását kívántuk felmérni a fent
említett pszichológiai tényezők mentén. Módszer: A vizsgálatban
42 krónikus dializált személy vett részt: 31 hemodializált és 11 hasi dialízist
végző vesebeteg. Átlagéletkoruk 63,33 ± 12,92 év. A minta életkor, nemi eloszlás
és családi állapot alapján reprezentatív. Kérdőíves technikával mértük a betegek
életminőségét, egészségműveltségét és betegségterhét.
Eredmények: Eredményeink szerint a peritonealis dialízist
végző betegek szignifikánsan magasabb egészségműveltséggel rendelkeznek, mint
hemodializált betegtársaik. Ez a jelentős különbség az életminőségük több
területén is kimutatható volt. Következtetés: Eredményeink a
betegedukáció és a kezelőszemélyzettől kapott támogatás (bátorítás)
jelentőségére hívják fel a figyelmet. A betegoktatás a hemodializált
betegcsoport esetében is kiemelten fontos. A klinikai szempontból hasznos
intervenciós javaslatokat fogalmaztunk meg, melyek célzottan az
egészségműveltség fejlesztésére irányulnak. Orv Hetil. 2021; 162(30):
1208–1215.

Summary.
Introduction: The symptoms of chronic kidney disease, the
peculiarities of the treatment greatly limit the patients’ daily life, affect
their physical and mental health and make their social relationships more
difficult. Objective: The purpose of this research is to
explore the health literacy, the health-related quality of life and illness
intrusiveness of Hungarian dialysis patients. Furthermore, we wanted to assess
the effect of treatment types along the psychological factors mentioned above.
Method: The sample consisted of 42 patients with chronic
kidney disease, 31 of whom have hemodialysis and 11 have peritoneal dialysis
treatment. Their mean age was 63.33 ±12.92 years. The sample is representative
by age, gender, and marital status. We measured the health-related quality of
life, the health literacy and illness intrusiveness of the patients using
special questionnaire techniques. Results: The peritoneal
dialysis patients have significantly higher health literacy than their
hemodialysis counterparts. This significant difference was seen in several areas
of their quality of life as well. Conclusion: Our results draw
attention to the importance of patient education and the special support by the
treatment staff. The patient education for the haemodialysis group is of
paramount importance for the hemodialysis group, too. We have formulated
clinically useful intervention proposals aimed at improving health literacy. Orv
Hetil. 2021; 162(30): 1208–1215.
Hol van a normális és a kóros vérnyomás közötti határ, és mi a terápiás cél a cardiovascularis és a renalis betegségekben?
Authors: Kékes Ede , Nagy Judit , Vályi Péter
Published: August 2021

Összefoglaló. Az irodalmi adatok arra utalnak, hogy a systolés
vérnyomás értékének emelkedése már 110–115 Hgmm-től együtt jár az
atherosclerosissal összefüggő elváltozások kialakulásával is és ezzel együtt a
cardiovascularis és a renalis funkció romlásával. Az összefüggés exponenciális,
de mértékét az életkor jelentősen befolyásolja. A kezelés során az elérendő
vérnyomás célértéke a jelenlegi adatok alapján 120–130 Hgmm között helyezkedik
el a 18–65 év közötti populációban; idősebb korban – különösen 80 év felett –
ennél magasabb, a 130 Hgmm alatti érték elérése nem reális, de talán nem is
szükséges. A leghelyesebb az egyéni vérnyomásprofil meghatározása, és számos
befolyásoló tényezőt is figyelembe kell venni a páciens legmegfelelőbb
kezeléséhez. A populáció egészségének javításához és megőrzéséhez az egyik
legfontosabb és leggyakoribb cardiovascularis kockázati tényezőt, a magas
vérnyomást időben fel kell fedezni, amihez a vérnyomást rendszeresen szükséges
ellenőrizni, és ezzel párhuzamosan kell végezni a prevenciót célzó
tevékenységeket (nevelés, oktatás, szűrés, egészségtudatos életmód) is. Orv
Hetil. 2021; 162(34): 1351–1361.

Summary. The data in the literature suggest that the increase in the
value of systolic blood pressure from 110–115 mmHg leads to the development of
atherosclerotic process and to the deterioration of cardiovascular and renal
function. The correlation is initially linear, then above 140–150 mmHg it is
already exponential, but it is also related to the progression of the age. The
systolic target for therapy is between 120–130 mmHg in the population aged
18–65; in older ages – especially over 80 years – it is higher and reaching the
value below 130 mmHg is unrealistic, and may even be not necessary. It is the
best to determine the individual treatment, taking into account the individual
blood pressure profile and the factors influencing the patient. In order to
improve and maintain the health of the population – in addition to unknown
hypertension – it is necessary to regularly monitor blood pressure and apply the
known preventive methods (education, training, screening, etc). Orv Hetil. 2021;
162(34): 1351–1361.
A tüdő immunfiziológiája – útjelzők a terra incognita felé
Authors: Balogh Péter
Published: August 2021

Összefoglaló. A tüdő a benne lévő légutak és a légzőhám felületének
kiterjedtsége, valamint a folyamatos napi gázcsere mennyisége miatt az
emlősszervezetnek a környezeti antigének számára legnagyobb mértékben kitett
közvetlen behatolási kapuja. A különböző antigénekkel szemben számos
fizikai-mechanikai tisztulási folyamat, valamint helyi és szisztémás
immunológiai védelmi mechanizmus együttesen biztosítja a légutak átjárhatóságát
és a megfelelő gázcseréhez a légzőhám és a tüdő interstitialis összetevőinek
szöveti integritását. A tüdő – veleszületett és adaptív immunológiai – védelmét
ellátó molekuláris és sejtes résztvevőkre, ezáltal a légutak alapvető
életfontosságú működésének biztosítására vonatkozó ismereteink az utóbbi időben
számos új megfigyeléssel bővültek, melyek felvetik a tüdő immunológiai
szerveződésének egyedi szerkezeti és funkcionális specializációját. A jelen
összefoglaló célja ezeknek az új eredményeknek a bemutatása, ezen keresztül a
tüdőben zajló sokrétű immunológiai folyamatok főbb jellemzőinek és a bennük
részt vevő sejtes és molekuláris összetevőknek az áttekintése. Ezek részletesebb
megismerése elősegítheti a légúti (köztük a SARS-CoV-2 általi) fertőzések után
fellépő, helyi és szisztémás immunpatológiai események pontosabb megértését és a
lehetséges terápiás eljárások kritikai értelmezését. Orv Hetil. 2021; 162(29):
1147–1155.

Summary. Due to the size of the surface area of airways and
respiratory epithelium combined with the daily amount of continuous gas
exchange, in mammalians the lung represents the most exposed organ serving as
immediate entry port for airborne antigens. Together with several
physicochemical clearance processes, both local and systemic immunological
defense mechanisms ensure the passage of airways and the tissue integrity of
respiratory epithelium and pulmonary interstitium necessary for the maintenance
of gas exchange. Several recent observations concerning the molecular and
cellular constituents of the pulmonary immunological defense have substantially
broadened our knowledge of the maintenance of the vital functionality of
airways, raising the unique specialization of the organization of pulmonary
immune compartment. The purpose of the present review is to highlight the main
findings on the complexity of pulmonary immunity, including the overview of the
main characteristics of its cellular and molecular participants. Unrevealing
these mechanisms may promote our understanding the local and systemic
immunopathological processes occurring after airway infections (including
SARS-CoV-2) and the critical assessment of potential therapeutic interventions.
Orv Hetil. 2021; 162(29): 1147–1155.
Posztakut COVID–19 szindróma
Authors: Szekanecz Zoltán , Vályi-Nagy István
Published: August 2021

Összefoglaló. A posztakut COVID–19 szindróma (PACS) az akut
betegséget követő 4–12 hét szubakut, tünetes szakasznak, valamint az ezt követő
krónikus poszt-COVID-időszaknak az együttesét jelenti. A PACS különböző
általános tünetekkel és szervi (pulmonalis, cardiovascularis,
neuropszichiátriai, endokrin, mozgásszervi, bőrgyógyászati, renalis)
manifesztációkkal jár. Ebben az összefoglalóban áttekintjük a PACS
kialakulásához vezető patogenetikai és rizikótényezőket. Bemutatjuk a klinikumot
és a diagnosztikát. A PACS ellátása alapvetően háziorvosi feladat, mely a szervi
tünetek gyógyszeres és nem gyógyszeres kezeléséből, multidiszciplináris
rehabilitációból és gondozásból áll. Kitérünk a háziorvos feladataira, a
szakellátásba történő beutalás indokaira és a poszt-COVID-hálózat létrehozásának
és működtetésének szükségességére is. Orv Hetil. 2021; 162(27): 1067–1078.

Summary. Post-acute COVID-19 syndrome (PACS) includes the subacute,
symptomatic phase 4–12 weeks after acute COVID-19 as well as the subsequent
chronic post-COVID-19 period. PACS is associated with various general symptoms
and organ (pulmonary, cardiovascular, neuropsychiatric, endocrine,
musculoskeletal, dermatological, renal) manifestations. In this summary, we
review the pathogenetic and risk factors leading to the development of PACS. We
present the clinical picture and diagnostics. PACS should usually be managed by
the general practitioner. The management of PACS includes pharmacological and
non-pharmacological treatment, multidisciplinary rehabilitation and regular
follow-ups. Here we also discuss the tasks of the general practitioner, the
reasons for referral to specialists and the need to set up and operate a
post-COVID-19 network. Orv Hetil. 2021; 162(27): 1067–1078.
Presentation of the Dossier - The royalty in the ancient Eastern world: Textual and image narratives
Authors: Santos João Batista Ribeiro , Pozzer Katia Maria Paim
Published: August 2021

The idea of organizing a dossier on Eastern Antiquity has haunted us for some years. As scholars of Eastern history and archeology, it is our duty to provoke debate and reflection on the ancient Near East in its various temporalities and regions. Thus emerged the thematic proposal on royalty in the ancient oriental world.
Presentación del dossier - La realeza en el antiguo mundo oriental: narrativas textuales y de imágenes
Authors: Santos João Batista Ribeiro , Pozzer Katia Maria Paim
Published: August 2021

La idea de organizar un dossier sobre la Antigüedad Oriental nos persigue desde hace algunos años. Como estudiosos de la historia y la arqueología orientales, es nuestro deber provocar el debate y la reflexión sobre el antiguo Cercano Oriente en sus diversas temporalidades y regiones. Así surgió la propuesta temática sobre la realeza en el antiguo mundo oriental.
A new extension of von Mises-Fisher distribution
Authors: MOGHİMBEYGİ Meisam , GOLALİZADEH Mousa
Published: August 2021

Spherical distributions, including the von Mises-Fisher density, have received a great attention in the literature because of their usefulness to model circular data lying on the unit sphere. However, there is a paucity of research on proposing spherical densities possing multimode tuned with a single parameter. To fill in this gap, we extend von Mises-Fisher distribution to construct a new density. Moreover, some of the important statistical properties of the proposed distribution including the estimation of parameters are highlighted. To evaluate the performance of the proposed distribution, some simulation studies and analyzing three real-life examples are presented.
Basic Concepts of Structural Design for Architecture Students
Authors:   Portland State University, Khodadadi Anahita
Published: August 2021

This book aims to narrate fundamental concepts of structural design to architecture students such that they have minimum involvement with math problem-solving. Within this book, students learn about different types of loads, forces and vector addition, the concept of equilibrium, internal forces, geometrical and material properties of structural elements, and rules of thumb for estimating the proportion of some structural systems such as catenary cables and arches, trusses, and frame structures.
Effect of different double-sided plastic films on chemical and fermentation characteristics of corn silage
Authors: Cristo Fernando Braga , Neumann Mikael , Sidor Fernando de Souza , Seller Maria Eduarda Cozechen , Plodoviski Daniel Corrêa , Carneiro Everton Luiz , Cesar Paulo Victor Pinheiro , Savoldi Leticia Santos , Costa Luísa da
Published: August 2021

Abstract The objective of this study was to evaluate the efficiency of different double-sided plastic films on chemical and fermentation characteristics, dry matter digestibility, aerobic stability, physical and dry matter losses in corn silages stored in bunker silos. This was a completely randomized experimental design consisting of three treatments: DF110µm - double-sided polyethylene with 110 µm thickness; DF200µm - double-sided polyethylene with 200 µm thickness; and DFBO - oxygen-impermeable film consisted of double-sided polyethylene with 80 µm thickness overlaid with a translucent vacuum polyamide film with 20 µm thickness. The use of DF200µm film increased the ruminal dry matter digestibility by 4.58% and reduced the silage temperature by 3.1 °C, as well as the physical losses of the corn silage were reduced by 118.9 g kg-1 DM using DFBO and 95 g kg-1 DM with DF200µm; DFBO resulted in the highest aerobic stability (127 hours) of corn silage. The use of DF200µm and DFBO is recommended for preserving corn silage in bunker silos.
Establishment of paiaguas palisadegrass in monoculture or in an integration system with other crops
Authors: Santos Filho José Ricardo dos , Sousa Bráulio Maia de Lana , Fagundes Jailson Lara , Backes Alfredo Acosta , Silva José William Teles , Andrade Gabriela Santos , Santos Anna Luiza Hora dos , Florêncio Rafaela Stefanny Rodrigues , Silva Vinícius Conceição da
Published: August 2021

Abstract The objective of this study was to evaluate the productive and structural characteristics of Paiaguas palisadegrass established in monoculture and intercropped with agricultural crops in 2018 and 2019. The evaluated treatments were: Paiaguas palisadegrass (PP) in monoculture, PP intercropped with maize, PP intercropped with sorghum, and PP intercropped with soybean. The experimental design used was a randomized block, with 4 replications (plots of 160 m²). Sward height, tiller density, dry mass production, and bulk density of total dry matter, of leaves, of stems, and of dead material were evaluated. The data were analyzed using the Tukey test at 5% probability. The total dry mass was higher in intercropping than in monoculture. Paiaguas palisadegrass intercropped with maize showed lower productions of total dry mass, leaf blade, and stems. The percentage of leaf blades was higher in Paiaguas palisadegrass intercropped in 2018 and in monoculture and intercropped with maize and soybean in 2019. Higher percentages of stems were registered in Paiaguas palisadegrass in monoculture in 2018 and in intercropping with sorghum in 2018 and 2019. In general, higher heights were found in Paiaguas palisadegrass in monoculture and smaller when intercropped with maize. The highest tiller densities were observed in Paiaguas palisadegrass in monoculture and the lowest in Paiaguas palisadegrass intercropped with maize and sorghum. Intercropping with agricultural crops reduces the production of Paiaguas palisadegrass. The accompanying agricultural crops alter the composition of the forage produced by the Paiaguas palisadegrass.
Elucidating tumor immunosurveillance and immunoediting: a comprehensive review
Authors: Silva Estela Vieira de Souza , Nascente Eduardo de Paula , Miguel Marina Pacheco , Alves Carlos Eduardo Fonseca , Moura Veridiana Maria Brianezi Dignani de
Published: August 2021

Abstract The action of the immune system against neoplastic diseases has become one of the main sources of research. The biological pathways of this system are known to contribute in limiting the progression and elimination of the tumor, and are delineated by concepts and mechanisms of immunosurveillance and immunoediting. Immunosurveillance is considered the process by which the immune system recognizes and inhibits the neoplastic process. The concept of immunoediting arises in the sense that immune system is able to shape the antigenic profile of the tumor due to selective pressure, based on the stages of tumor elimination, balance and evasion. The immune response occurs against tumor antigens and changes in the tumor microenvironment, involving different components of the innate immune system, such as T cells, natural Killer cells, B lymphocytes and macrophages. In this sense, knowing these concepts and understanding their respective mechanisms becomes essential in the investigation of new strategies for cancer prevention and cure. Thus, this review presents historical aspects and definitions of immunosurveillance and tumor immunoediting, with emphasis on its importance and applicability, such as on the different methods used in immunotherapy.
Consideration of the permanent deformation of soils used in flexible pavement design
Authors: Cabral Wendel Silva , de Araújo Barroso Suelly Helena , de Almeida Torquato e Silva Samuel
Published: August 2021

The decreasing supply of soils with geotechnical parameters suitable for pavement designs is a problem. To establish more efficient designs and adequate construction criteria, it is essential to understand the performance of materials. In this work, the permanent deformation (PD) of soils used in pavement layers was studied using prediction models of PD and modulus of resilience in addition to the design of pavement structures using mechanistic–empirical and empirical methods. The multistage repeated load triaxial test was used along with numerical analyses of stresses and displacements using the CAP3D program. The results showed that both the test procedure and the prediction models satisfactorily obtained the PD behaviour. Moreover, designs using the methods adopted resulted in distinct structures (i.e. different thicknesses of granular pavement layers). From the results of this study, it was concluded that both the model and the test procedure show significant potential for characterising and modelling the PD of granular materials.
Particle-scale observation of seepage flow in granular soils using PIV and CFD
Authors: Sanvitale N. , Zhao B. D. , Bowman E. T. , O'Sullivan C.
Published: August 2021

Seepage-induced instabilities pose a challenge in many geotechnical applications. Particle-scale mechanisms govern the initiation of instability. However, current understanding is based on a macro-scale perspective that draws on continuum mechanics. Recent developments in imaging and numerical analysis can provide the particle-scale fundamental perspective needed to develop a comprehensive insight. This contribution demonstrates the value of combining particle-scale experimental and numerical studies. The experiments consider transparent soil samples created using refractive image matching and monitored by particle image velocimetry (PIV). Three-dimensional pore topology is extracted from a series of two-dimensional images and imported into computational fluid dynamics (CFD) simulations. Permeability is estimated by three distinct approaches: using flow rate, PIV- and CFD-generated data. The flow fields obtained from PIV and CFD are in good agreement considering both flow rate contour plots and flow rate distributions; this demonstrates the successful reconstruction of three-dimensional pore structure and flow-field analysis. The comparison also reveals that the side boundary effects in CFD simulations are constrained within a limited region. The multi-plane results characterise the variance of flow velocity with the three-dimensional pore topology. Finally, the fluid–particle interactions obtained from CFD results show a larger variance in the angular particle packings.
Use of the EN 12390-10 outside protected test as a tool for determining carbonation resistance
Authors: Harrison Thomas Alexander , Jones Rod , Kandasami Sivakumar , Newlands Moray
Published: August 2021

From first principles, criteria for the EN 12390-10 outside protected test have been developed and compared with existing practice. These criteria align well with the UK recommendations but are more conservative than the current French and Spanish requirements. The EN 12390-10 outside protected test is unsuitable for classification as this would require anybody using the procedure with identical concrete to get the same result. Unfortunately, current tests that are suitable for classification, whilst safe, do not reflect the real performance of slowly reacting cements. Improving the test for classification purposes will take time and meantime the use of the EN 12390-10 outside protected test and the criteria given in this paper provides a procedure by which both sustainability and durability may be achieved. The downside of this test is its slowness and, therefore, it is only suitable for type testing or the determination of limiting values and other criteria to be used in specifications or production.
Study on dynamic multiaxial tension–compression properties of different types of concrete
Authors: Shang Huai-Shuai , Zhou Jun-Hao , Xie Zong-Long
Published: August 2021

The mechanical properties of four types of concrete, tested under multiaxial (biaxial tension–compression, triaxial tension–compression–compression) dynamic (strain rates of 10−5, 10−4, 10−3 and 10−2 s−1) complex stress states with different stress ratios, were compared and analysed. The same test apparatus was used in order to avoid test errors caused by differences of the triaxial testing machine. The aim of this work was mainly to determine the dynamic multiaxial (DM) strengths of the four concrete types. It was found that the mechanical behaviour of the four concretes was similar to a certain extent. The DM strengths of the concretes increased with an increase in strain rate and their DM strengths in any direction were lower than the concrete static strength under uniaxial tension and compression. The influence of strain rate and stress ratio on the DM strengths of the concretes were compared and analysed. A unified failure criterion was developed, expressed by the octahedral stress space criterion, of the various concrete types under DM tension and compression. This investigation provides a theoretical foundation for the design and checking of structures subjected to DM load conditions.
Inhibiting Focal Adhesion Kinase Ameliorates Cyst Development in Polycystin-1–Deficient Polycystic Kidney Disease in Animal Model
Authors: He Jinzhao , Zhang Shun , Qiu Zhiwei , Li Xiaowei , Huang Huihui , Jin William , Xu Yue , Shao Guangying , Wang Liang , Meng Jia , Wang Shuyuan , Geng Xiaoqiang , Jia Yingli , Li Min , Yang Baoxue , Jenny Lu Hua A. , Zhou Hong
Published: August 2021

Significance Statement

Focal adhesion kinase (FAK) has been widely studied and shown to have a crucial effect on tumor progression. Although autosomal dominant polycystic kidney disease (ADPKD) shares numerous commonalities with tumors, it is undetermined whether FAK is involved in cyst development. Our study demonstrates that inhibiting FAK activity using small molecule FAK inhibitor VS-4718 ameliorates ADPKD progression and improves renal function. Inhibiting FAK and its downstream Src signaling suppresses cAMP-mediated aberrant proliferation of cystic epithelial cells in ADPKD animals. This study highlights the therapeutic potential of small molecule FAK inhibitors in treating patients with ADPKD.

Background

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by numerous cysts originating from renal tubules and is associated with significant tubular epithelial cell proliferation. Focal adhesion kinase (FAK) promotes tumor growth by regulating multiple proliferative pathways.

Methods

We established the forskolin (FSK)-induced three-dimensional (3D) Madin–Darby Canine Kidney cystogenesis model and 8-bromoadenosine-3`,5`-cyclic monophosphate–stimulated cyst formation in ex vivo embryonic kidney culture. Cultured human renal cyst–lining cells (OX-161) and normal tubular epithelial cells were treated with FAK inhibitors or transfected with green fluorescent protein–tagged FAK mutant plasmids for proliferation study. Furthermore, we examined the role of FAK in two transgenic ADPKD animal models, the kidney-specific Pkd1 knockout and the collecting duct–specific Pkd1 knockout mouse models.

Results

FAK activity was significantly elevated in OX-161 cells and in two ADPKD mouse models. Inhibiting FAK activity reduced cell proliferation in OX-161 cells and prevented cyst growth in ex vivo and 3D cyst models. In tissue-specific Pkd1 knockout mouse models, FAK inhibitors retarded cyst development and mitigated renal function decline. Mechanically, FSK stimulated FAK activation in tubular epithelial cells, which was blocked by a protein kinase A (PKA) inhibitor. Inhibition of FAK activation by inhibitors or transfected cells with mutant FAK constructs interrupted FSK-mediated Src activation and upregulation of ERK and mTOR pathways.

Conclusions

Our study demonstrates the critical involvement of FAK in renal cyst development, suggests that FAK is a potential therapeutic target in treating patients with ADPKD, and highlights the role of FAK in cAMP-PKA–regulated proliferation.
SLAV CULTURAL MEMORY, NOSTALGIA AND HUMOURIN THE OEUVRE OF DANILA VASSILIEFF (1897-1958), RUSSIAN ÉMIGRÉ ARTIST IN AUSTRALIA
Authors:   Institute for Literature and Arts, Bojić Zoja
Published: August 2021

Danila Vassilieff(1897–1958) was a Russian émigré artist who lived and worked in Australia. By far the largest and most significant part of his painterly and sculptural oeuvre Vassilieff executed on Australian soil, in the states of New South Wales and Victoria.This article explores Vassilieff’s visual arts ideas and idiom created within the parameters of his Russian and Slav cultural memory and characterised by his émigré experience. It argues that Vassilieff’s art was fully formed only after the artist’s experiencing anexistence of a permanentémigré in Australia and that both his ideas andhis idiom flourished in opposition to the cultural traditions of his new environment.Vassilieff’s relationship with his Russian and Slav cultural heritage was traced in the monograph Imaginary homelands, the art of Danila Vassilieff(Bojic2007). This essaycomplements the extant research by examiningVassilieff’s relationship with his Australian environment as reflected in his work. Vassilieff’s experience of a permanent émigré formed his visual arts idiom and provided for the large pool of themes and topics in his work. Much of his oeuvrebridgedthe varied cultural traditions of his Russian homeland and the hardshiphe experienced living in a barren Australian land. There weretwo reasonsfor this. One was the artist’s positionof being an émigré; the other was that of being an artist. His initial alone-ness in a new Australian environment allowed for his one-ness and thus contributed to the uniqueness of his expression and his oeuvre, recognised as such later on by his Australian peers. Thechronic trauma of being a permanentémigré was a continualfeature of Vassilieff’slife and of his work. Hisdeep feelings ofnostalgiawerean essential quality of his existence in exile.The artist himself would attempt to counterbalance 19this with his all-pervasive energetic good will and his refined sense of humour and sweet ironyon occasions leading into a sarcasm, evident in many of his works.
(AUTO) EROTICISM OF MOURNING. THE INVENTION OF BORISAV STANKOVIĆ'S NARRATIVE PROCESS IN THE STORY THE DECEASED'S WIFE
Authors:   University of Zagreb, Bogutovac Dubravka
Published: August 2021

The article analyzes the story of Borisav Stanković Decedent's Wifein the context of his novelist opus and opus in its entirety. Particular attention is paid to the narrative treatment of the subject of eroticism in relation to the context of the theme of death, characteristic of the entire Stanković's work. The narrator's position is considered, which has variable focalization, which tells the elements of modernity. The modernity of the story is expressed in its formal and content plan: the formal, readable fluency of the narrative voice, and the content, the opening of topics that have the status of the obscure.
THE ROLE OFMACEDONIAN COMPOSER AND ETNHNOMUSICOLOGIST ŽIVKO FIRFOV IN CONTEMPORARY MACEDONIAN MUSIC CULTURE
Authors:   Institute of National History University of Ss. “Cyril and Methodius”, Didenko Nataša
Published: August 2021

This paper presentsthe life and activities of Živko Firfov, who is observedas one of the important artists of Contemporary Music Culture in the History of Macedonian music. Firfov is significant in Macedonian music because he has made a great contribution todiscovering, writing, acquainting and affirming Macedonian folk music both domestically and abroad.
GENDER-MARKED CONCEPTUAL METAPHOR WOMAN IS A BIRD (USING EXAMPLES FROM BULGARIAN AND CROATIAN LANGUAGES)
Authors:   University in  Zagreb, Vasung Ana
Published: August 2021

The subject of the paper is the gender marked conceptual metaphor WOMAN IS A BIRDin two closely related languages − Bulgarian and Croatian languages. The corpus of analyzed ornithonyms, which are metaphorically used for a female referent, was collected from general monolingual and phraseological dictionaries, as well as online and slang dictionaries. Some meanings were illustrated by examples from the online corpora hrWac and Bulgarian web 2012 through the use of the Sketch engine tool. Even though domestic and wild birds are evenly represented in the analyzed corpus, the domestic birds are semantically and metaphorically more productive. The contrastive analysis established that the majority of metaphors are based on anthropomorphism, and that pejorative terms, which serve to semantically derogate women, dominate over terms with positive connotations. We have found pejorative connotations and hints of sexism even in the case of terms of endearment, which are supposed to express a special intimacy and congeniality. Interlingual differences, in the sense of the existence of more specific meanings, are realized within the framework of age and sexual connotation. The interlingual and intralingual variations (Kövecses, 2005, 2015) are the result of the dependency of metaphorical meaning on context and participants in the communication process.
FRATRICIDE OR PATRICIDE –THE CRISIS OF PATRIARCHY IN THE NOVELS ĐUKA BEGOVIĆBY IVAN KOZARAC AND ZEMJABY ELIN PELIN
Authors:   University in  Zagreb, Bijelić Marijana
Published: August 2021

Sincethe plots of the novels Đuka Begovićand Zemja(Land) by Elin Pelin are constructed around the ancient mythical murder motifs of patricide and fratricide, this analysis relies on mimetic theory by Rene Girard that is also constructed as a theoretical explanation of the afore mentioned mythical murders. Although Girard denies libidinal and object-directed causation of desire, in his polemics with the Freudian model of the libidinal desire Girard implies that there is a privileged object of desire in the patriarchal order –i.e. women because the father is the natural model for the son, and men’s desire for women is interindividually directed and intensified. Money and some other types of property are the privileged objects in a capitalist society –since thedesires of all members of the society are concentrated around them. The crisis of patriarchal order in Đuka Begovićcauses the loss of degree and the elevation of the structural positions of the father and the son, which then becomes the motive for Đuka’spatricide. On the other hand, the idealization and the persevered authority of the older brother causes Enjo’s repentance and the semi-establishing of the patriarchal order in the novel Zemja. The idealized older brother in the Pelin’s novel preserves thefunction of the paternal authority, and the father in Kozarac’s novel loses his authority and degree so he functions as the rival brother within the framework of the Girardian mimetic theory.
PERCEPTION OF THE IMAGE OF STAKHANOVKA: FAN LETTERS TO DUSYA VINOGRADOVA, 1935–1936
Authors:   European University at St. Petersburg, Navolotskaya D. I.
Published: August 2021

The main question of the article is why Soviet citizens of different professions and ages wrote letters to Stakhanovka, who was the first Soviet celebrity. To answer it, the author relies on "celebrity studies", a new direction in the social sciences and humanities, in which historians turn to the study of "celebrity culture". In the article, a celebrity is seen not as a status assigned to an individual and providing prestige and other social dividends, but as an analytical tool for analyzing the culture of society. Therefore, to study the mechanisms of the emergence and spread of celebrities, it is important to shift the research focus from studying the personality of a public figure to fame in general. In other words, it is important to pay attention to the cultural practices of consuming the image of a public figure, as well as to the political and social mechanisms by which these practices were constructed. Referring to "celebrity culture" as a tool for analysis, the author demonstrates that in the 1930s, the Soviet Union was not an anomaly in comparison to the Western societies. The Soviet culture of celebrity was the basis of the planned economy and the authoritarian regime, but this did not exclude the presence of non-repressive, democratic phenomena among the audience of the central Soviet press.
AN “ALIMONY HUNTER” OR A “VICTIM”: SINGLE MOTHER AS A CATEGORY IN THE 1950s AND 1960s SOVIET EVERYDAY LIFE
Authors:   Institute of Russian History, Russian Academy of Sciences, Voronova E. A.
Published: August 2021

The article shows that in Soviet society single motherhood existed in a variety of forms. The author claims that Soviet single mothers were contradictory figures, as the 1944 Family Law stated that non-marital childbearing women were officially supported by the pro-natal state. Contemporaries usually did not make any difference between war widows with children, unmarried women with children from cohabitation with men, and «real» single mothers. According to the author, between the 1950s and 1960s, the image of single motherhood in USSR fluctuated from the positive model of a woman, trying her best in single child-rearing to a predatory woman, the «gold digger» who was engaged in adultery with married men and ruined «normal» Soviet families. On the basis of letters to the authorities, the author shows how the term «single motherhood» was associated with the positive and negative sides of Soviet motherhood. Mothers usually refused to identify themselves as «single mothers» because of social stigma, so they chose different strategies in self-representation. Finally, the unstable and contradictory position of Soviet single mothers in people’s minds demonstrates both the issues of gender order and social and cultural shifts in the post-war USSR.
ALEXANDER CHAYANOV’S THEORY OF PEASANT FARMING AND PERSONAL SUBSIDIARY FARMS IN THE SOVIET VILLAGE (MID-1930s – 1980s)
Authors:   Ural Federal University, Gorbachev O. V.
Published: August 2021

The paper analyzes the possibility of applying the theory of peasant farming by Alexander Chayanov to personal subsidiary farms (LPH) of collective farmers and state farm workers. It is noted that the significant factors affecting their functioning were rural urbanization and the demographic evolution of the rural family, as well as the policy of severe administrative restrictions on individual households. Despite the unfavorable conditions for development, personal part-time farms have demonstrated stability over time. The relations between family size and farm size noted by Chayanov were distorted by a system of repressive taxation, active off-farm employment of farm members, and natural processes of family deformation under the influence of urbanization. The author characterizes why LPH have lost their function of the main source of livelihood. It is concluded that ideological restrictions led to an artificial archaization of production within part-time farms and limited their evolution along the farm route, i.e. the labor-consumer balance in the budget of a rural family was achieved at an extremely low level. On the other hand, it is the spread of non-mechanized manual labor in personal part-time farms that allows the author to largely apply the provisions of Chayanov’s theory of peasant farming.
Simulation of Hall field elements based on nanoscale silicon-on-insulator heterostructures
Authors: Mordkovich V. N. , Abgaryan K. K. , Reviznikov D. L. , Leonov A. V.
Published: August 2021

The article is devoted to the issues of numerical simulation of field Hall sensors based on the "silicon on insulator" structure with two control gates. To solve the problem, a two-level local-one-dimensional computational model is used. At the first level, a series of one-dimensional Schrödinger—Poisson equations are solved, which describe the distribution of the electron density across the heterostructure in different sections. The obtained information is transmitted to the second level, where the current characteristics of the element are calculated. The numerical simulation results are compared with the experimental data obtained for field Hall sensors. Comparative analysis shows good agreement between calculated and experimental data. The developed computer model makes it possible to carry out a multivariate analysis of various heterostructures, which creates the basis for optimizing devices of the class under consideration.
Choice of HPC cluster performance indicators for the example of the "Informatika" Center for Collective Use of the FRC CSC RAS
Authors: Zatsarinny A. A. , Volovich K. I. , Denisov S. A. , Ionenkov Yu. S. , Kondrashev V. A.
Published: August 2021

This article discusses a methodology for assessing the effectiveness of a high-performance research platform. The assessment is carried out for the example of the "Informatika" Center for Collective Use (CCU) established at the Federal Research Center of the Institute of Management of the Russian Academy of Sciences, for solving new materials synthesis problems. The main objective of the "Informatika" Center for Collective Use is to conduct research using the software and hardware of the data center of the FRC IU RAS, including for the benefit of third-party organizations and research teams. The general characteristics of the "Informatika" Center for Collective Use are presented, including the main characteristics of its scientific equipment, work organization and capabilities. The hybrid high-performance computing cluster of the FRC CSC RAS (HHPCC) is part of the data center of the FRC IU RAS and also part of the “Informatika” Center for Collective Use. HHPCC provides computing resources in the form of cloud services as software (SaaS) and platform (PaaS) services. With the aid of special technologies, scientific services are delivered to researchers in the form of subject-oriented applications. Based on the analysis of the structure and operation principles of the Informatika Center, key performance indicators of the Center have been developed taking into account its specific tasks in order to characterize its various activity aspects (development, activities and performance). CCU efficiency evaluation implies calculation, on the basis of the developed indicators, of overall (generalized) indicators that characterize the CCU operation efficiency in various areas. An integral indicator is also calculated showing the overall CCU efficiency. To develop the overall performance indicators and the integral performance indicator, it is suggested to use the methods of weighted average and analysis of hierarchies. The procedure of determining partial performance indicators has been considered. Specific features of the choice of CCU performance indicators for solving new materials synthesis problems have been identified that characterize computing complex capabilities in the creation of a virtualization environment (peak performance of a computing system, real performance of a computing system on specialized tests, equipment loading with applied tasks and program code efficiency).
EVALUATION OF THE ØREBLUE® METHOD IN THE TREATMENT OF TINNITUS AND HYPERACUSIS: RESULTS OF A MONOCENTRIC OBSERVATIONAL EFFECTIVENESS STUDY IN 74 PATIENTS
Authors: CHETRITT-BONNEYRAT Natacha , BIANCO Erkki
Published: August 2021

Background

Øreblue® is a new treatment method for tinnitus and hyperacusis combining auditive rehabilitation and psychological therapy. The present monocentric observational retrospective study was to assess patient’s judgements of its effectiveness.

Material and methods

From January 2011 to June 2015, 74 consecutive healthy patients (male/female, 51/23; median age, 51.5 years) with chronic tinnitus (without hyperacusis, 32) or hyperacusis (with tinnitus, 42) were treated according to priority at the Hearing Institute of Resources (La Rochelle, France). They were asked to rank their discomfort, quality of life, and sleep quality before and 1 month after treatment using 10-point scales ranging from 0 (no discomfort, poor quality of life, or poor sleep quality) to 10 (unbearable discomfort, best quality of life, or best sleep quality) and their global impression of change on a 10-point scale ranging from 0% (not improved) to 100% (fully improved). These data which were reported in patient medical files were retrospectively analysed in 2018.

Results

Discomfort, which was severe at inclusion (8.9±0.8), drastically decreased after treatment (change: 8.5±1.3). Quality of life and sleep improved (from 2.2±1.4 and 2.0±1.9 to 8.3±1.4 and 4.9±2.1, respectively). 81.3% of the patients with tinnitus and 100% of patients with hyperacusis claimed to be fully improved. No adverse events were reported during the study.

Conclusions

The Øreblue® method was effective on discomfort related to tinnitus or hyperacusis; it greatly improved quality of life and sleep. Further studies, especially multicentric or randomised, possibly with imaging and long-term follow-up, should be performed to strengthen these encouraging findings.
Assessing enrichment of proteins in the mitochondrial fraction in HEK cells v1
Authors: HARDING OLIVIA
Published: August 2021

This is a method for measuring protein enrichment on mitochondria in various conditions. In the resulting Western blot, one can assess the level of contamination of other organelles in the enrichment prep.
[RETRACTED] GrownMD CBD Gummies Reviews - For Healthy Sleep & Quit Smoking! Safe Or Fake? v1
Authors: not provided health
Published: August 2021

[RETRACTED]

As already stated, GrownMD CBD Gummies is a THC-free dietary supplement that helps with anxiety, depression, and other health problems. GrownMD CBD Gummies are scientifically-tested supplements packed with various organic ingredients that help improve overall health.
Alcohol Consumption Practices Among Nepali Migrant Workers in Shah Alam, Selangor
Authors:   College of Nursing, Al-Bayan University, Baghdad, Ghazi Hasanain Faisal , Abdalqader Mohammed , Baobaid Mohammed Faez ,   International Medical School, Management & Science University, Selangor, Malaysia, Ariffin Indang Ariati ,   International Medical School, Management & Science University, Selangor, Malaysia, Fatima Mariam-Aisha ,   Research Management Centre, Management & Science University, Malaysia, Mohd Azhar Afrisya Adlina ,   International Medical School, Management & Science University, Selangor, Malaysia., Ma’arof Muhammad Mukhlis ,   International Medical School, Management & Science University, Selangor, Malaysia, Hassan Mohd Rohaizat ,   Department of community health, UKM Medical Centre, Kuala Lumpur, Malaysia.
Published: August 2021

Malaysia has been considered an industrialized country and there is a demand for manpower in low-skilled jobs which usually filled by migrant workers. Therefore, this study focused to identify the level of alcohol consumption and its associated factors particularly among Nepali migrant workers in Shah Alam, Selangor. A cross-sectional study using a convenient sampling method was conducted among 233 Nepali migrant workers in Shah Alam, Selangor using a self-administered questionnaire. A validated scoring system by DASS 21 and The Alcohol Use Disorder Identification Test was employed. The results show that 60.09% of Nepali workers consumed alcohol with most of them are in low (31.43%) and medium (29.28%) risk level for alcohol consumption. The empirical findings reveal a significant association between income, education level, and peer pressure (p value<.001 respectively) with alcohol consumption. However, the study found no association between age, marital status, years of working, and body mass index (p value= 0.44, 0.19, 0.42, 0.40 respectively) with alcohol consumption. In a conclusion, most Nepali migrant workers consume alcohol but in low and medium risk severity for alcohol consumption. The results highlight sociodemographic factors such as income and education as well as peer pressure among important factors affecting alcohol consumption.