bluuebunny/crossref_metadata_2025 huggingface dataset:
Siddha management of alcohol withdrawal syndrome
Authors:   Department of Nanju Maruthuvam, National Institute of Siddha, Chennai - 47, Tamil Nadu, India, Selvasankari E
Published: January 2023

Addictive use of Alcohol has been a considerable health problem, not only having impact on individual and families, but creates a lasting social burden on the society. One third of the Indian population is using alcohol in an unhealthy manner, the complications are wide and varied among which, the Alcohol withdrawal syndrome (AWS) is the dominant factor. AWS is a set of symptoms that can occur when a heavy drinker suddenly stops or significantly reduces their alcohol intake. The presentation varies from mild sleep loss or anxiety to the life threatening situation like delirium (confusion). The excessive intake of unwholesome alcohol leads to Mathathiyam (Kudiveri Noi in the Siddha – Indian Tamil language) and it degrades knowledge and health according to Siddha medicine and practise. Manifestation occur as per the aggravated/ vitiated three biological forces (Vali, Azhal, Iyyam – Indian Tamil language) leads to cause impair the quality or efficiency of life, and which may even leads to death. Hence, there is a need for AWS management at an early stage. The aim is to minimize the withdrawal symptoms which prevents complications and reduces the intense use for alcohol using the siddha system of medicines. The efficacy of Inji rasayanam (Rejuvenator), Brahmi nei (Medicated ghee), and Ammukkara chooranam (Medicated powder) for AWS is well known. Therefore, it is of interest to describe the case of a 35 years old male patient presented with AWS and treated with Siddha drugs for 48 days. The condition was assessed before and after treatment using the clinical institute withdrawal assessment for alcohol scale revised (CIWA-Ar). Data shows effective management of AWS using the Siddha medicines.
A short review on guided implant surgery and its efficiency
Authors:   Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical & Technical Sciences, Chennai- 600077, Tamilnadu, India, Rajasekar Arvina
Published: January 2023

Ideal implant placement may reduce surgical complications, such as nerve injury and lingual cortical plate perforation, and minimize the likelihood of functional and prosthetic compromises. Guided implant surgery [GIS] has been used as the means to achieve ideal implant placement. GIS refers to the process of digital planning, custom-guide fabrication, and implant placement using the custom guide and an implant system–specific guided surgery kit. GIS includes numerous additional steps beyond the initial prosthetic diagnosis, treatment planning, and fabrication of surgical guides. Substantial errors can occur at each of these individual steps and can accumulate, significantly impacting the final accuracy of the process with potentially disastrous deviations from proper implant placement. Pertinent overall strategies to reduce or eliminate these risks can be summarized as follows: complete understanding of the possible risks is fundamental; knowledge of the systems and tools used is essential; consistent verification of both diagnostic and surgical procedures after each step is crucial; proper training and surgical experience are critical. This review article summarizes information on the accuracy and efficacy of GIS, provides insight on the potential risks and problems associated with each procedural step, and offers clinically relevant recommendations to minimize or eliminate these risks.
Structural characterization and active site prediction of keratinase from Bacillus flexus
Authors:   Department of Biotechnology, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies [VISTAS], Pallavaram, Chennai, Tamil Nadu, India, Prakash Balu
Published: January 2023

Sixteen keratinolytic bacteria were isolated from poultry farm soil samples. The highest keratinlytic enzyme producers of Bacillus flexus was confirmed with 16S rRNA sequence analysis. It is of interest to understand the binding efficiency of the modelled keratinase from Bacillus flexus with different substrates using molecular docking studies. Data provides insights for the identification of substrate recognition patterns, and the development of suitable enzymes to improve their use in keratin degradation.
Effect of outdoor games among school children in Northern Gujarat, India
Authors:   Department of  Psychiatric  Nursing, Nootan College of Nursing, Sankalchand Patel University, Visnagar, Gujarat - 384315, India, Sivasubramanian N
Published: January 2023

Outdoor play works as an important tool for the children education. Providing a natural learning environment for children helps them to have an active and fulfilling life. Also, higher levels of attention and well-being are promoted when children play in green outdoor spaces. The importance of play for children's healthy development is grounded in a strong body of research. The study used an experimental research methodology, and data was obtained from 60 school-aged children using a purposive sample strategy and a checklist. The mean, standard deviation, and chi square test were used to analyze the data. After giving act out method, majority (85%) of the school age children had adequate knowledge, 15% of the school children had moderate knowledge regarding outdoor games and its importance. In data analysis the mean of pretest score was6.43 and mean of post test score was 15.88. The mean difference was 9.45. Post test mean was more than pretest mean, which indicate the effectiveness of actout method on deficiency of outdoor game among school children. The standard deviation of pretest knowledge score was 3.9; the post test knowledge score was 2.47. The computed’t’ value was 16.1, the DF was 59, and the P value was 1.67, all of which are significant. Religion, monthly income, and the age of the children all had an impact on the calculated chi square value. According to the findings of this study, the act out method was successful in boosting understanding about the lack of outdoor games among school-aged children.
Antimicrobial and antioxidant activities of fennel oil
Authors:   Department of Biotechnology, Jamia Millia Islamia, New Delhi – 110025, India, Naaz Sheeba
Published: January 2023

It is of interest to estimate the effects of foliar spray (ISA) on essential oil yield, chemical constituents, antioxidant, and antimicrobial activities of fennel (Foeniculum vulgare Mill).Fennel was treated with ISA solutions at 40 and 80 mg L-1 doses. Application of ISA significantly augmented antioxidant and antimicrobial activities in addition to essential oil yield and its principal elements in fennel. 80 mg L−1 dose of ISA was found to be pre-eminent. Antioxidant properties of EOs were determined through DPPH assays, metal chelators and lipid peroxidation. While antimicrobial activities were evaluated using agar well diffusion and microdilution techniques of broth. Gram positive and Gram negative bacteria were used to gauge the oil's antibacterial effectiveness. Data shows that antioxidant and antimicrobial activities of fennel oil were found to be the highest. According to GC analysis, trans-anethole (78.38-86.08%), methyl chavicol (2.32-2.54%), and fenchone (6.65-8.95%) were the three main constituents of fennel essential oil.
Changes in diabetic and renal profile of people exposed to fluoride in south India
Authors:   Sri Devaraj Urs Medical College, Kolar – 563103, Shashidhar, Kurpad Nagaraj
Published: January 2023

Type 2 Diabetes Mellitus is leading cause of Diabetic microvascular complications. India stands second across the globe in prevalence of diabetes mellitus. Due to deficit rain fall, the water table is exposed to more of salts and minerals from the rocks underground. One of the minerals is the Fluoride. Fluoride in negligible amount is good for dental health, chronic exposure to higher range of fluoride causes various metabolic disturbances. Aim: To study the effect of chronic fluoride exposure on diabetes mellitus. A total of 288 study subjects were recruited. The blood samples and urine samples were collected from all the study subjects. Study groups; Group1: Healthy Controls, Group2: Type 2 Diabetes Mellitus and Group3: Diabetic Nephropathy. The serum (0.313± 0.154) and urine (0.3±0.6) fluoride values of diabetic nephropathy group were significantly decreased in comparison between groups. The primary objective of the fluoride with insulin (-0.06) levels are inversely correlating and fluoride with microalbumin (0.083) levels are directly correlating. Results of the study gave a clear picture of effect of fluoride on insulin action and renal damage. In conclusion, though there is no significant effect of fluoride on FBS, PPBS and HbA1c, insulin is the determining factor for glucose homeostasis which is decreased. Microalbumin is yet another marker for renal clearance which is increased. Therefore, fluoride shall be considered as a parameter in prognosis of metabolic disorder especially Diabetes mellitus in fluoride endemic areas.
Knowledge and awareness on pneumoconiosis among dental technicians and senior dental technology students in Saudi Arabia
Authors:   Department of Prosthodontics, Dental Lab Technology, College of Applied Medical Sciences, Riyadh Elm University, Riyadh- Kingdom of Saudi Arabia, Kausher Hina
Published: January 2023

Dental technicians' pneumoconiosis is a condition that causes interstitial inflammation and fibrosis as a result of complex drug exposure. Therefore, it is of interest to assess and evaluate the knowledge and awareness about pneumoconiosis and other respiratory disorders among dental technicians and dental technology students in Saudi Arabia. A cross sectional survey was conducted on convenient sample of 300 senior dental technician students and dental technicians from Saudi Arabia and informed consent was obtained. The participants were approached through online questionnaire using Google forms. Questions were related to the socio-demographic data, knowledge and awareness of the students and the practicing dental technicians and their willingness to learn about pneumoconiosis. Final year undergraduate, interns and Dental technicians were included, undergraduate students without practical knowledge and experience and participants with history of respiratory disease were excluded from the study. Questions were assessed by face validity. The data was analyzed using Statistical Package for Social Sciences software. Descriptive statistics was calculated. 34.8% of the study group were not aware of the term and don’t know about the etiology of pneumoconiosis. Pearson correlation was significant in terms of awareness difference between males and females and females had less awareness compared to males.
Comparative docking analysis of tyrosine kinase inhibitors with HER2 and HER4 receptors
Authors:   Department of Pharmaceutics, Progressive Education Society’s, Modern College of Pharmacy, Nigdi, Pune, M.S, India, Sonar Priyanka
Published: January 2023

Tyrosine kinase receptors promote the growth and differentiation of normal breast and malignant human breast cancer cells, known as ERBB receptors. Various ERBB receptors are EGFR/ErbB1 and ErbB2/neu, which get over expressed in different solid tumors that activate upon binding of ligand to the extra cellular domain of these receptors. Of note, the epidermal growth factor receptor (EGFR) is a prime contributor to cancer through the involvement of four receptor tyrosine kinases (RTKs), namely, HER1, HER2, HER3, and HER4. Among them, HER2 and HER4 are majorly associated with breast cancer. Non-peptide quinazoline compounds homologous of the adenosine triphosphate (ATP) are competitively inhibited to RTKs to prevent cancer growth and metastasis. Various small drug molecule that targets the RTKs having the same scaffold, includes Lapatinib, Tivozanib, Erlotinib, Gefitinib, Crizotinib, and Ceritinib. The present study aims to investigate the comparative potential of structurally similar TKIs against HER2 and HER4 receptor receptors-silico molecular docking using FlexX software (LeadIT 2.3.2). Each docked complex's interaction profile was performed using BIOVIA Discovery Studio Visualizer 4.0. Molecular docking analysis was performed in order to get deeper insights into the interaction and binding pattern of the ligands with HER2 and HER4 receptors. The docking results revealed the Lapatinib compound acquired the relatively highest binding score of -32.36 kcal/mol and -35.76 kcal/mol with HER2 and HER4 proteins, respectively, concerning other compounds. Lapatinib is identified as a potential inhibitor for both the RTKs. Our study thus suggests the probable direction that could be further explored in inhibiting EGFR protein harbouring breast cancer.
Dental restoration selection by students at southern Saudi Arabian universities
Authors:   Faculty of Dentistry, Najran University, KSA, Asiri Waleed
Published: January 2023

Dental caries is a serious oral health concern and restoration of teeth is the main solution to this issue. Various restorative materials having different properties are used for posterior restoration. The aim of this study was to find that which factors can affect the choice of selection of material for posterior restoration among dental graduate students. For this purpose, a questionnaire was shared electronically among students of three different universities (King Khalid University, Jazan University, and Najran University). After collection, data were subjected to a chi-square test to check the significance. It has been observed that almost 50% of participants choose composite resin for posterior restoration. Results showed that according to most (more than 50%) of the dental students in Southern Saudi Arabia, different patient and tooth condition related factors can affect the choice for selection of restorative material.
Linking inflammatory mediators and indicators of insulin resistance in anthropometry specified type 2 diabetic males
Authors:   Department of Biochemistry, Apollo Institute of Medical Sciences and Research (AIMSR), Chittor campus, Murukambattu, Chittoor 517127 Andhra Pradesh, India, Bonam Venkata Ramesh
Published: January 2023

Inflammation associated with insulin resistance is a risk factor in the development of complications in Type 2 diabetes mellitus (T2DM). The study was conducted to assess the relationship between inflammatory mediators and insulin resistance, independent of lipid profile in anthropometry specified male Type 2 diabetics. 180 males having T2DM for more than 5yrs and on diabetic medication were chosen for the study and categorized into obese and overweight. Patients with thyroid or other endocrine disorders, kidney, muscle, liver, systemic, and inflammatory diseases were excluded from the study. Blood glucose, glycated hemoglobin, plasma insulin, and the inflammatory biomarkers namely hs-CRP, ferritin, haptoglobin, and adiponectin were evaluated. HOMA-IR and QUICKI were computed to assess insulin resistance. The study demonstrated significant changes in adiponectin and hsCRP in obese and overweight T2DM. However, Ferritin and Haptoglobin were insignificant. The entire biochemical study was carried out to demonstrate lipid profile independent associations. The significant insulin resistance associated with a substantial increase in hs-CRP levels and a pronounced decrease in the adiponectin levels suggests impending diabetic complications in anthropometry specified male T2DM. This could promote the use of personalised medicine to regulate levels of hs-CRP or to improve the secretion of adiponectin thereby countering insulin resistance in T2DM, independent of the lipid profile which is the novelty of our study.
Predicting Consumers’ Intention to Shop Online in an Emerging Market: A COVID-19 Perspective
Authors:   Department of Business Administration, Metropolitan University, Sylhet, Islam Afsarul , Anjum Nishath ,   Department of Business Administration, Metropolitan University, Sylhet, Ahmed Imran ,   Department of Business Administration, Global University Bangladesh
Published: January 2023

As an emerging economy, Bangladesh has witnessed a remarkable development in adopting information and communication technologies over the last decade. Hence, the fi eld of e-commerce is expanding rapidly and consumers are now using the internet as an alternative channel for buying. The fundamental purpose of this study is to predict consumers’ intention to purchase online during the COVID-19 pandemic in Bangladesh. Based on the Theory of Planned Behavior (TPB), this study attempts to explore certain factors (attitude towards online shopping, subjective norms, perceived behavioral control) aff ecting consumers’ online buying intention. A structured questionnaire has been used to collect the primary data through the CAWI survey method. A total of 157 respondents have participated in this study from diff erent universities in Sylhet city, Bangladesh. This study employed multiple regression analysis to test the proposed research model. The fi ndings indicate that all the predictors have a signifi cant impact on consumers’ behavioral intention to do online shopping during the COVID-19 pandemic. However, any developing country like Bangladesh has a genuine need for more research works on the e-commerce fi eld. This study provides some valuable insights into the adoption of the online shopping system in an emerging economy which helps the e-commerce industry to understand online consumers’ behavior to develop various marketing strategies accordingly. The study also contributes to the body of knowledge both at the academic and practical levels.
Factors Influencing Young Consumers’ Impulse Intentions Toward Visiting Pop-Up Stores in South Africa
Authors:   Department of Marketing, Supply Chain and Sport Management, Tshwane University of Technology/ Department of Consumer and Food Sciences, University of Pretoria, South Africa, Retief Miriam-Miri , Jacobs Bertha ,   Department of Consumer and Food Sciences, University of Pretoria, South Africa, Fiore Ann-Marie ,   Department of Apparel, Events, and Hospitality Management, Iowa State University, USA
Published: January 2023

Consumers are constantly seeking out new and memorable experiences. This study empirically examines how external factors, such as the characteristics of innovation (relative advantage, trialability, observability, low complexity, compatibility) and exterior store design, and internal factors (positive mood, hedonic motivations, consumer innovativeness) aff ect young consumers’ impulse intention toward visiting pop-up stores in the South African context. Survey data was collected from a convenient sample of 461 students from two universities in South Africa via a self-administered questionnaire. Multiple regression analysis revealed that (a) external factors related to the characteristics of innovation (i.e., compatibility and low complexity), (b) exterior store design, and (c) the internal factor, consumer innovativeness, had a signifi cant influence on consumers’ impulse intentions to visit pop-up shops. The study examined pop-up retail through the lens of impulse behaviour in an emerging market. The study contributes to the understanding of factors influencing the success of pop-up stores in emerging markets. In particular, the understanding of the factors that lead to impulse intentions towards pop-up retail, which has been overlooked in research.
Tres àmfores completes d'època mig-imperial procedents de la vil·la romana de la Boella (La Canonja, Tarragona)
Authors: Colom Mendoza Enric , López Vilar Jordi , Járrega Domínguez Ramon
Published: January 2023

Presentem, l’estudi i contextualització de tres àmfores completes trobades a la vil·la romana de La Boella (La Canonja, Tarragona). Destaquem especialment que es tracta de tipus poc presents al Camp de Tarragona: dues àmfores mig-imperials itàliques Dressel 2 i una àmfora tarraconense Dressel 2 evolucionada, ambdues pròpies de cronologies de finals de s. II i principis del III dC.
La cova del Colmenar de Domenyo 90 anys després del seu descobriment: un exemple de cova-santuari iberica en la comarca valenciana de la Serranía
Authors: Burriel Alberich Josep Maria , Ruiz López Juan José
Published: January 2023

Prompte es cumpliran cent anys del descobriment de la cova del Colmenar de Domenyo pel Laboratori d'Arqueologia de la Universitat de València. Si bé la cova s'ajusta a les característiques que els especialistes determinen que ha de complir una cova-santuari ibèrica, durant quasi 100 anys, curiosament, la cova ha estat "desapareguda" per al món científic. Afortunadament la prospecció del poblament ibèric de la comarca valenciana de la Serrania, va permetre la seua localització, la incorporació al PGOU de Domenyo i a l'inventari de jaciments de la Conselleria d'Educació, Cultura i Esports de la Generalitat valenciana.
Entre El Argar, el Bronce valenciano y el Bronce de la Mancha: las aportaciones del asentamientos de Gorgociles del Escabezado II (Jumilla, Murcia)
Authors: Jover Maestre Francisco Javier , Hernández Carrión Emiliano , Pastor Quiles María , Basso Rial Ricardo , López Padilla Juan Antonio
Published: January 2023

Gorgociles del Escabezado II (Jumilla) es un pequeño asentamiento de inicios del II milenio cal BC, localizado en el altiplano murciano. Este territorio ha sido escasamente explorado e investigado, habiendo sido adscrito a lo largo del tiempo a las tres grandes áreas culturales definidas para la Edad del Bronce en el cuadrante suroriental de la península ibérica: El Argar, Bronce Valenciano y Bronce de La Mancha. A partir de las características de este enclave se puede comenzar no solo a descartar su adscripción al área argárica, sino también comenzar a reflexionar y cuestionar la existencia tanto del Bronce Valenciano como del Bronce de La Mancha.
Reseña. Resiliencia en espacios desindustrializados
Authors: Cuello Llobell Francesc
Published: January 2023

Resumen: En esta obra se presenta el reto que supone la gestión de los espacios que fueron industrializados y que en la actualidad sufren un proceso de desindustrialización como consecuencia de las crisis del capitalismo y de la deslocalización de los procesos productivos. A parte de los efectos directos de este proceso, como son el aumento del paro y la aparición de espacios sin una función (aún) definida, aparecen también otras consecuencias relacionadas con las sociedades que han vivido estos espacios en fases anteriores al declive y cierre de las diferentes actividades analizadas en el texto. Así, los diferentes casos estudiados a lo largo de la obra muestran las diferentes respuestas en diferentes localizaciones a este proceso de desindustrialización, así como un mayor o menor grado de éxito a la hora de crear espacios resilientes con el patrimonio industrial heredado desde la Revolución Industrial, o incluso desde las sociedades proto-industriales tanto en España como en América Latina.
 
Palabras clave: desindustrialización, patrimonio industrial, resiliencia, reconversión, reutilización.
Experiencias docentes en el Diplomado en Evaluación de Políticas en Materia de Seguridad: construyendo conocimientos en derechos humanos, desarrollo territorial y seguridad pública
Authors: Uribe Cortez Jaime
Published: January 2023

Resumen: El documento que aquí se presenta es una oportunidad para dar cuenta de la experiencia que quien suscribe posee en relación con la enseñanza de las políticas públicas y las nociones de derechos humanos y seguridad pública para el desarrollo comunitario. El problema principal radica en que para conocer a fondo las estructuras del mundo es menester adentrarse en la arquitectura de la ciencia y las maneras especializadas en que se vinculan desde una mirada breve hacía la Ley de Educación Estatal del Estado de Quintana Roo, en particular del año 2022 y algunas reflexiones. El principal aporte radica en dar cuenta de la importancia de la experiencia en la construcción articulada de conceptos y categorías en el abordaje de ambas temáticas en el marco de su inclusión en el campo municipal y territorial de las políticas. 
       
Palabras clave: conceptos, estructuras, vínculos, teoría-praxis, Quintana Roo (México).
El porqué de la cooperación al desarrollo. Aproximación a los factores determinantes a partir de la técnica “Iceberg”
Authors: Quint Sascha Gunter
Published: January 2023

Resumen: La literatura pertinente sobre los factores que determinan la cooperación humana ha cubierto una amplia cadena de áreas: aspectos culturales y religiosos, normas sociales y leyes, la orientación hacia el futuro, la naturaleza humana, los genes del ser humano, la moral y cómo las sociedades se estructuran y organizan. Por otro lado, existen factores condicionantes de la cooperación entre estados como el prestigio y/o la buena reputación, la moral y la ética, las normas existentes y las estructuras organizacionales. Este artículo proporciona al lector, en un primer paso, una aproximación a los factores influyentes en la cooperación entre seres humanos y entre estados en la cooperación interestatal. En un segundo paso, se realiza una comparación sistemática de los factores para ambas formas de la cooperación mediante la aplicación del modelo “Iceberg”. Se concluye que conocimientos más profundos sobre los factores determinantes y sus interrelaciones, mediante futuros estudios e investigaciones podrían resultar fundamentales para la mejora de los resultados de la cooperación al nivel regional, nacional e internacional entre individuos, comunidades, organismos internacionales y países.
 
Palabras clave: Cooperación Humana, Cooperación Internacional entre Estados, Factores Determinantes, Ser Humano, Estado, Modelo Iceberg.
 
Abstract: Relevant literature on the factors that determine human cooperation has covered a wide range of areas such as cultural and religious aspects, social norms and laws, future orientation, human nature, human genes, morality, and how societies are structured and organized. On the other hand, there are conditioning factors of cooperation between states such as prestige/good reputation, morals/ethics, existing norms and organizational structures. This article provides the reader in a first step with an approach to the influencing factors of cooperation between human beings and of interstate cooperation. In a second step, a systematic comparison of the factors for both forms of cooperation are made through the application of the Iceberg model. It is concluded that deeper knowledge about the determinants and their interrelationships through future studies and research could be fundamental for the improvement of cooperative action at the regional, national, and international levels between individuals, communities, international institutions, and countries.
 
Key words: Human Cooperation, International Cooperation among States, Determining Factors, Human Being, State, Iceberg Model.
Hacer que cada persona cuente: el censo colaborativo y participativo de personas sin hogar en la ciudad de València
Authors: Botija Yagüe Mercedes , Galán-Sanantonio Alba , Gallén-Granell Eva
Published: January 2023

Resumen: El sinhogarismo se caracteriza por la ausencia o limitación del acceso a una vivienda digna. Es un fenómeno producido por diversas causas en diferentes áreas de la vida de un individuo. Las personas sin hogar constituyen un grupo poblacional difícil de definir y cuantificar, sin embargo su estudio es necesario para poder elaborar políticas públicas para mejorar su bienestar. Debido al aumento de la precariedad y la vulnerabilidad, cada vez hay más gente en riesgo de exclusión residencial. Es por ello por lo que en la ciudad de València se ha ido gestando un proyecto para poder acercarse a esta realidad, lo cual se acabó materializando en el “Diagnóstico relativo al recuento de las personas sin hogar en la ciudad de València”. Los resultados muestran  la detección de 831 y 754 personas sin hogar en los dos diferentes años en los que se realizó este estudio, tanto en situación de calle como en albergue. De la misma forma, ha posibilitado la creación de una red de sinergias entre las distintas administraciones en  materia de sinhogarismo para la mejora de la intervención. Así, también ha incidido en la movilización y participación activa de la ciudadanía de València, y en las propias personas sin hogar, las cuales han podido formar parte de su propio cambio. Todo esto ha asentado las bases para futuros estudios en la propia ciudad y su expansión a diferentes municipios.
 
Palabras clave: exclusión residencial, sinhogarismo, personas sin hogar, València, censo.
Reseña. De la especulación al derecho a la vivienda. Más allá de las contradicciones del modelo inmobiliario español
Authors: Fernández-Serrano Andreu Blai
Published: January 2023

Resumen: En el presente libro, Raquel Rodríguez Alonso y Mario Espinoza Pino desarrollan las principales transformaciones políticas en materia de vivienda a partir de la crisis de 2008. Para ello, es necesario comprender el modelo inmobiliario español en su evolución histórica moderna, que arranca con el franquismo. Frente a la crisis habitacional que se cierne sobre la población española, la urgencia de un alquiler social y la falta e insuficiencia de las medidas políticas, los autores plantean un abanico amplio de medidas que podrían implementarse en el corto, medio y largo alcance con el objetivo de garantizar el derecho a la vivienda y el derecho a la ciudad.
 
Palabras clave: vivienda, urbanismo, alquiler, derechos sociales, derecho a la ciudad.
“Volver al pueblo”: el trabajo en red de COCEDER para abordar todas las aristas de la problemática de la despoblación
Authors: Duran Santacatalina Paula
Published: January 2023

Resumen: El Centro de Desarrollo Rural La Safor es una Organización No Gubernmental (ONG) sin ánimo de lucro, con sede en las localidades de Beniarjó y Rafelcofer (Safor – València) e integrada en la Confederación de Centros de Desarrollo Rural (COCEDER), una ONG de Acción Social de ámbito estatal. Desde hace diecisiete años trabajamos con y por las personas del mundo rural, dando respuesta a las demandas de esta población a través de iniciativas sociales, educativas y culturales, como acciones de solidaridad o voluntariado, que buscan, como objetivo principal, intervenir y mejorar la calidad de vida de la población rural, así como la salud del territorio, ya que también realizamos investigaciones medioambientales sobre la comarca. La función de nuestro centro se dirige a toda la población rural, pero sobre todo a los colectivos más vulnerables, desprotegidos o en situaciones de riesgo de exclusión social. Es por ello que desde nuestro centro se trabaja la inclusión social de la sociedad rural desde un servicio integral, destacando en nuestra intervención el acompañamiento centrado en cada caso. Es aquí donde ejecutamos el programa “Volver al Pueblo”, en el que trabajamos para evitar el abandono de la población rural, para atraer nuevas familias o personas pobladoras y para promover la economía rural.
 
Palabras clave: despoblación, asociacionismo, participación, repoblación, rural, calidad de vida, inclusión social, economía rural, solidaridad, acción social, territorio, medioambiente, población rural, intervención integral, volver al pueblo, Safor.
Los Centros CEDES como espacios de innovación social: acceso a los recursos de formación y empleo en entornos rurales
Authors: Arzo Cabrera Ana Belén , Sales Jordi Montse , Fuster Roig Purificación , Membrado Aparici Lucía , Pérez Sádaba Alberto
Published: January 2023

Resumen: El Centro de Desarrollo Rural La Safor es una Organización No Gubernmental (ONG) sin ánimo de lucro, con sede en las localidades de Beniarjó y Rafelcofer (Safor – València) e integrada en la Confederación de Centros de Desarrollo Rural (COCEDER), una ONG de Acción Social de ámbito estatal. Desde hace diecisiete años trabajamos con y por las personas del mundo rural, dando respuesta a las demandas de esta población a través de iniciativas sociales, educativas y culturales, como acciones de solidaridad o voluntariado, que buscan, como objetivo principal, intervenir y mejorar la calidad de vida de la población rural, así como la salud del territorio, ya que también realizamos investigaciones medioambientales sobre la comarca. La función de nuestro centro se dirige a toda la población rural, pero sobre todo a los colectivos más vulnerables, desprotegidos o en situaciones de riesgo de exclusión social. Es por ello que desde nuestro centro se trabaja la inclusión social de la sociedad rural desde un servicio integral, destacando en nuestra intervención el acompañamiento centrado en cada caso. Es aquí donde ejecutamos el programa “Volver al Pueblo”, en el que trabajamos para evitar el abandono de la población rural, para atraer nuevas familias o personas pobladoras y para promover la economía rural.
 
Palabras clave: despoblación, asociacionismo, participación, repoblación, rural, calidad de vida.
Targeted sensors for glutamatergic neurotransmission
Authors: Hao Yuchen , Toulmé Estelle , König Benjamin , Rosenmund Christian , Plested Andrew JR
Published: January 2023

Optical report of neurotransmitter release allows visualisation of excitatory synaptic transmission. Sensitive genetically-encoded fluorescent glutamate reporters operating with a range of affinities and emission wavelengths are available. However, without targeting to synapses, the specificity of the fluorescent signal is uncertain, compared to sensors directed at vesicles or other synaptic markers. We fused the state-of-the-art reporter iGluSnFR to glutamate receptor auxiliary proteins in order to target it to postsynaptic sites. Chimeras of Stargazin and gamma-8 that we named SnFR-γ2 and SnFR-γ8, were enriched at synapses, retained function and reported spontaneous glutamate release in rat hippocampal cells, with apparently diffraction-limited spatial precision. In autaptic mouse neurons cultured on astrocytic microislands, evoked neurotransmitter release could be quantitatively detected at tens of synapses in a field of view whilst evoked currents were recorded simultaneously. These experiments revealed a specific postsynaptic deficit from Stargazin overexpression, resulting in synapses with normal neurotransmitter release but without postsynaptic responses. This defect was reverted by delaying overexpression. By working at different calcium concentrations, we determined that SnFR-γ2 is a linear reporter of the global quantal parameters and short-term synaptic plasticity, whereas iGluSnFR is not. On average, half of iGluSnFR regions of interest (ROIs) showing evoked fluorescence changes had intense rundown, whereas less than 5% of SnFR-γ2 ROIs did. We provide an open-source analysis suite for extracting quantal parameters including release probability from fluorescence time series of individual and grouped synaptic responses. Taken together, postsynaptic targeting improves several properties of iGluSnFR and further demonstrates the importance of subcellular targeting for optogenetic actuators and reporters.
How students perceive the teacher’s use of humour and how it enhances learning in the classroom
Authors: Bakar Farhana , Mallan Vijay
Published: January 2023

Recently, scholarship on humour in teaching and learning has focused on the use of instructional humour. Past studies have reported that instructional humour is best used as a pedagogical tool for teaching and learning purposes. Nevertheless, how students perceive instructional humour and how humour enhances learning in the classroom is still not clear. This exploratory study aims to gain further understanding of students’ interpretation of teachers’ use of humour in relation to teaching and learning in a higher education context. In particular, it aims to explore the perspectives of students as to how the use of humour in the classroom enhances their learning. Data were collected from one-to-one in-depth interviews with 10 undergraduate students who were learning with award-winning teachers at a research-intensive university in New Zealand. Students explained a variety of ways in which humour enabled their process of learning. These included helping them to concentrate, remember and understand learning content by connecting humour to content. Additionally, a sense of rapport and positive attitude towards learning and the teacher were indicated as contributing to the learning environment. Our findings indicate that students considered instructional humour a tool that enhanced their learning cognitively and emotionally.
Jokes in Italian as a foreign language: comprehension, funniness, and sharing
Authors: Platas-García Alejandra , Reyes-Meza Verónica , Castro-Manzano J.-Martín
Published: January 2023

This paper analyses whether the comprehension of a joke in Italian as a foreign language is influenced by personal or task elements, whether comprehension influences the perception of funniness, and whether perceived funniness affects intention to share the jokes. A quantitative cross-sectional study was performed. Participants were all native Spanish speakers from Mexico who also read Italian as a foreign language. There were 61 participants, aged 19-64 years (Mage = 26.3; SD = 9.4), comprising 42 females and 19 males. Comprehension was measured using a multiple-choice test. Funniness was measured by a perception scale and sharing was measured by determining intention to share. The objectives were fourfold: to identify whether factors related to the test-taker (gender, occupation, and age) influenced comprehension; to investigate whether factors related to the test task (level of language, reading support, and prior knowledge) influenced comprehension; to explore if comprehension influenced the perception of funniness; and to determine whether funniness influenced the intention to share. To statistically evaluate these question, four generalized linear models were constructed (one corresponding to each objective). The results indicated that: (i) the test-taker’s occupation affects comprehension (p = 0.0499); (ii) the interaction of all of the test-task factors influences comprehension (p = 0.03087); (iii) comprehension affects funniness (p <0.001); and (iv) perceived funniness influences sharing (p <0.001). Finally, a discussion of these results is presented.
Assessing factors influencing students’ perceptions towards animal species conservation
Authors: Mota Pereira Heliene , Braga-Pereira Franciany , Azeredo Luane Maria Melo , Lopez Luiz Carlos Serramo , Romeu Nóbrega Alves Rômulo
Published: January 2023

Background

The way humans perceive and interact with non-human animals is particular to each person, from antipathetic interactions evidenced by fear, aversion or repulsion, to empathy evidenced by feelings of affection, enchantment and interest in the animal. In this sense, herein we investigated the perception of university students about species belonging to different classes of wild vertebrates and the influence of social and educational factors on that.

Methods

Data were obtained through online forms answered by 700 university students from nine Brazilian states, 328 females and 372 males, aged between 18 and 65 years. The form had eight sentences to be answered in relation to 17 species of wild vertebrates. The agreement level for each of these sentences was to be indicated using a five-point Likert scale. The sentences were designed to assess aesthetic, risk, utilitarian, and preservation perceptions attributed to each species by students.

Results

We found that species perceived as useful by the students are generally also perceived as beautiful and as those that should be preserved. On the other hand, we found similarity between the species perceived as ugly and those that should not be preserved; and between the species perceived as harmful and those considered dangerous. Female and lower-income students more often agree that animals are harmful. We found that perceptions of danger in relation to animals were predominantly associated with younger respondents. However, this did not lead to less support for conservation among these students, as students of all age groups agree that species should be preserved. Our results show that students’ knowledge area was an important predictor associated with empathetic and antipathetic perceptions. Environmental area students showed greater empathy in all analyzed categories (beauty, usefulness, harmlessness, and preservation) than non-environmental areas students. On the other hand, students from the area of the exact sciences showed greater dislike in all analyzed categories than students from other areas. We found a strong relationship between the areas “Environmental” and “Humanities, Languages and Arts” for the attitudinal factors associated with utility and preservation, suggesting a similar empathetic worldview for students in these areas.

Conclusions

We found that the perception directed towards wild vertebrates varies according to the gender, age, income and study area of the students, in addition to the taxon considered. Finally, our results indicate that negative perceptions should be taken into account in environmental education efforts, educational policies and in planning fauna conservation plans which should incorporate the most diverse audiences, and not only encompass charismatic species but extend to animals that arouse great aversion from the part of people.
Eight single nucleotide polymorphisms and their association with food habit domestication traits and growth traits in largemouth bass fry (Micropterus salmoides) based on PCR-RFLP method
Authors: Cui Jiao , Jiang Zhou , Wang Zerui , Shao Jiaqi , Dong Chuanju , Wang Lei , Li Xuejun , Du Jinxing , Li Shengjie , Qiao Zhigang , Zhang Meng
Published: January 2023

Background

The largemouth bass (Micropterus salmoides), an economically important freshwater fish species widely farmed in China, is traditionally cultured using a diet of forage fish. However, given the global decline in forage fish fisheries and increasing rates of waterbody pollution and disease outbreaks during traditional culturing, there is a growing trend of replacing forage fish with formulated feed in the largemouth bass breeding industry. The specific molecular mechanisms associated with such dietary transition in this fish are, nevertheless, poorly understood.

Methods

To identify single nucleotide polymorphisms (SNPs) related to food habit domestication traits and growth traits in largemouth bass fry, we initially genotyped fry using eight candidate SNPs based on polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, with genetic parameters being determined using Popgen32 and Cervus 3.0. Subsequently, we assessed the associations between food habit domestication traits of largemouth bass fry and these SNPs using the Chi-square test or Fisher’s exact test. Furthermore, we used a general linear model to assess the relationships between the growth traits of largemouth bass fry and these SNPs. The Pearson correlation coefficient between growth traits and the SNPs was also determined using bivariate correlation analysis in IBM SPSS Statistics 22. Finally, the phenotypic variation explained (PVE) by the SNPs was calculated by regression analysis in Microsoft Excel.

Results

The genotyping results obtained based on PCR-RFLP analysis were consistent with those of direct sequencing. Five SNPs (SNP01, SNP02, SNP04, SNP05, and SNP06) were found to be significantly correlated with the food habit domestication traits of fry (P < 0.05); SNP01 (P = 0.0011) and SNP04 (P = 0.0055) particularly, had showed highly significant associations. With respect to growth traits, we detected significant correlations with the two SNPs (SNP01 and SNP07) (P < 0.05), with SNP01 being significantly correlated with body length, and height (P < 0.05), and SNP07 being significantly correlated with body height only (P < 0.05).

Conclusions

Our findings indicated that the PCR-RFLP can be used as a low-cost genotyping method to identify SNPs related to food habit domestication and growth traits in largemouth bass, and that these trait-related SNPs might provide a molecular basis for the future breeding of new varieties of largemouth bass.
Novel ethyl p-methoxy cinnamate rich Kaempferia galanga (L.) essential oil and its pharmacological applications: special emphasis on anticholinesterase, anti-tyrosinase, α-amylase inhibitory, and genotoxic efficiencies
Authors: Begum Twahira , Gogoi Roktim , Sarma Neelav , Pandey Sudin Kumar , Lal Mohan
Published: January 2023

Background

Kaempferia galanga (L.) is one of the prospective therapeutic plants with an aromatic rhizome, and belongs to the Zingiberaceae family. This herb is commonly used by local practitioners in traditional Asian medicine.

Methods

In the present investigation, the novel Kaempferia galanga rhizome essential oil rich in ethyl p-methoxy cinnamate (EMCKG) was evaluated using GC/MS for chemical composition analysis. EMCKG was analyzed for its possible antimicrobial, neurodegenerative inhibitory, acetylcholinesterase, anti-inflammatory, and antioxidant activities as well as for the genotoxic effects using the standard methodologies. ANOVA and post hoc was performed to test the statistical significance of the study.

Results

GC/MS analysis identified ethyl p-methoxy cinnamate as the major component of EMCKG essential oil with an area percentage of 66.39%. The EMCKG exhibited moderate (DPPH assay IC50 = 15.64 ± 0.263 µg/mL; ABTS assay IC50 = 16.93 ± 0.228 µg/mL) antioxidant activity than standard ascorbic acid (DPPH assay IC50 = 21.24 ± 0.413 µg/mL; ABTS assay IC50 = 21.156 ± 0.345 µg/mL). Similarly, EMCKG showed comparable activity in albumin denaturation (IC50 = 2.93 ± 0.59 µg/mL) and protease inhibitor assay (IC50 = 17.143 ± 0.506 µg/mL) to that of standard sodium diclofenac (IC50 = 23.87 ± 0.729 µg/mL and IC50 = 19.18 ± 0.271 µg/mL, respectively). The EMCKG exhibited a dose-dependent antimicrobial activity pattern with the highest inhibitory activity at 500 µg/mL against Staphylococcus aureus and considerable anticholinesterase activities (IC50 = 21.94 ± 0.109 µg/mL) compared to the standard galanthamine (IC50 = 27.18 ± 0.511 µg/mL). EMCKG also showed strong anti-diabetic activity (IC50 = 18.503 ± 0.480 µg/mL) and anti-tyrosinase activity (IC50 = 14.756 ± 0.325 µg/mL) as compared to the standards used (acarbose IC50 = 20.39 ± 0.231 µg/mL and kojic acid IC50 = 17.73 ± 0.192 µg/mL) in the study. Genotoxicity analysis of EMCKG revealed that at 1 µg/mL concentration has no toxic effects in mitosis of Allium cepa roots (Mitotic Index MI = 13.56% and chromosomal aberration CA = 07.60%). The ANOVA confirmed that except for the anticholinesterase activity, there is insignificant difference for essential oil and standards used for all the other bioactivities thus confirming their interchangeable applicability.

Conclusions

Current research provides the basis for the fact that besides being a rich source of ethyl p-methoxycinnamate, EMCKG has the potential for future formulation and development of an inexpensive skin-care agent and for the preparation of anti-diabetic drugs.
Pluralismo en la TV local, regional y comunitaria chilena. Voces tras las cámaras
Authors:   Universidad de Chile, Sáez Baeza Chiara , Fuente-Alba Fernando ,   Universidad Católica de la Santísima Concepción (Chile), Avilés Jorge ,   Investigador independiente
Published: January 2023

El artículo presenta los resultados de un estudio cualitativo en torno al pluralismo mediático a través de entrevistas semiestructuradas a trabajadores/as y directivos/as de 28 canales chilenos de televisión regional, local y comunitaria. Las principales áreas de indagación fueron autopercepción, sostenibilidad financiera, digitalización, sostenibilidad social e institucionalidad. Entre los resultados, destaca una comprensión del pluralismo centrada en el pluralismo político y el de género, y como un concepto que se sobreentiende antes que se problematiza. Se considera la falta de recursos económicos como el principal obstáculo que impide el pluralismo y se observa un bajo nivel de conocimiento sobre las obligaciones legales relativas a este. Se concluye respecto de la necesidad de fortalecer el sector desde las políticas públicas, incluyendo promover mecanismos que permitan a estos canales participar de manera equitativa en los mercados relevantes de la industria televisiva.