bluuebunny/crossref_metadata_2025 huggingface dataset:
INTENSITY OF OXIDATIVE STRESS DEVELOPMENT IN RAT MAJOR CEREBRAL HEMISPHERES UNDER COMBINED CONDITIONS OF SYSTEMIC INFLAMMATORY RESPONSE, CHANGES IN THE NORMAL LIGHT-DARK CYCLE, AND FLUOXETINE ADMINISTRATION
Authors: Volkova O.A. , Kostenko V.O.
Published: September 2024

At present, the relevance of examining changes to the normal light-dark cycle is increasing, and the connection between the development of the systemic inflammatory response (SIR) and circadian rhythm disorders has been confirmed. The effects of antidepressants on the human body are also actively studied. The aim of this study was to investigate the effect of fluoxetine on oxidative stress in the rat cerebral hemispheres under conditions of acute desynchronosis (AD), systemic inflammatory response (SIR), and fluoxetine administration. Material and methods. The study was conducted on 44 white Wistar rats weighing 150-200 kg of various articles, divided into 3 groups: control (15), a combination of AD and SIR (14), and a combination of AD, SIR, and fluoxetine (15). To simulate AD, a normal "light-dark" cycle (12 hours of light, 12 hours of darkness) was formed for 3 weeks, and the next 3 days the "light-dark" phases were shifted back by 6 hours. SIR was reproduced via intraperitoneal injection of Salmonella typhi lipopolysaccharide in the first week of 0.4 μg/kg 3 times a week, and in the following seven weeks – once a week. Fluoxetine was administered intragastrically for 21 days at a dose of 10 mg/kg and dissolved in 0.5 ml of distilled water at room temperature. In 10% of the homogenate of the large hemispheres of the brain, the rate of production of superoxide anion radical (SAR), the content of products that react with thiobarbituric acid (TBA-reactants), their increase, and the activity of catalase and superoxide dismutase (SOD) were determined. Results. The administration of fluoxetine in combination with AD and SIR reduced the rate of basic SAR production by 35.4%, NADPH-induced production by 34%, increased NADH-induced production by 65%, decreased the concentration of TBA-reactants by 23.7% and their augmentation by 54.3%, increased the activity of SOD by 85.7% and catalase by 12.4% compared to the group of combination of SIR and AD. Conclusions. When fluoxetine is administered alongside AD and SIR, it results in reduced baseline and NADPH-induced SAR production, increased NADH-induced production, decreased accumulation of TBA-reactants, and enhanced antioxidant activity in the rat cerebral hemispheres.
COLLABORATIVE ONLINE INTERNATIONAL LEARNING: SUGGESTIONS FOR UKRAINIAN MEDICAL EDUCATION AND INTERDISCIPLINARY COOPERATION
Authors: Lysanets Yu.V. , Ward J. , Zhang C. , Downing T. , Bieliaieva O.M.
Published: September 2024

This paper examines the experience of implementing Collaborative Online International Learning (COIL) projects at Coventry University and explores their potential application in the context of Ukrainian higher medical education. The aim of this paper is to demonstrate the feasibility of applying Coventry University's experience in organizing and implementing COIL exchanges in the academic setting of medical and ecological education in Ukraine, thereby fostering enriching opportunities for students and staff to collaborate at the intersection of healthcare, sustainability, business, and law. Materials and methods. The authors outlined the benefits of COIL initiatives between partners, as well as possible challenges in their implementation relying on the corpus of research papers published within the last 5 years available online in PubMed, Google Scholar and other databases, applying the methods of analysis and synthesis, systematization, generalization, comparative and contrastive methods. Results. Given the current conditions of the Russian invasion and martial law in Ukraine, COIL seems to be particularly relevant, providing a vital avenue for global collaboration in education when physical travel abroad may be difficult or impossible. The emphasis on cultural immersion, global perspectives, and the adaptability of the projects make COIL a promising direction for enriching both students and staff within the Ukrainian higher education framework. Highlighting the transformative potential of COIL, the paper proposes potential topics for interdisciplinary COIL projects between healthcare, ecology, business & law professionals. Conclusions. In the context of Ukrainian higher education, the paper suggests that adopting COIL exchanges could enhance collaboration between institutions, empowering students and providing flexible tools for achieving educational objectives. COIL exchanges offer a pathway to enhance educational outcomes while nurturing vital skills and perspectives essential for students and staff to thrive in an increasingly interconnected world.
The role of Biermann battery mechanism in appearance of magnetic fields in accretion discs
Authors: Andreasyan R. R. , Marchevsky I. K. , Mikhailov E. A.
Published: September 2024

At present, there is little doubt that accretion discs surrounding compact astrophysical objects such as black holes, white dwarfs and neutron stars may have magnetic field structures. Thus, they explain the transfer of angular momentum between different parts of the disc and some other processes. There are various ways to explain the occurrence of these magnetic fields. In this paper we study the possibility of generation of magnetic fields due to the Biermann battery mechanism. It is associated with radial flows of protons and electrons. Due to their different masses, they interact differently with the rotating medium, producing circular currents that generate magnetic fields. Previously, a similar process was studied for galactic discs and it was shown that the battery mechanism can generate initial magnetic fields in such objects. Here we discuss the action of the Biermann battery for accretion disks. This requires solving an integral equation of the second kind, which arises if we take into account the self-interaction of the magnetic field. It is shown that corresponding fields are quite significant and can play an important role in the evolution of magnetic fields in discs.
Is the young star association ε Cha double?
Authors: Bobylev V. V. , Bajkova A. T.
Published: September 2024

The kinematics of the ε Cha young stellar association close to the Sun has been studied based on a list of candidate stars from the Dickson-Vandervelde work. The working sample consists of 26 stars with parallaxes, proper motions from the Gaia DR3 catalog and radial velocities taken from literary sources. The orbits of the stars back to the past were constructed, and the moment when the association had a minimum spatial size was determined, as well as an analysis of the dependencies of the velocities U, V, W on the coordinates x, y, z was carried out. It is shown that the initial sample is divided into two parts with different kinematic properties. The first sample included 9 stars. Based on the construction of the orbits of these 9 stars, an age estimate of t = 4.9 ± 0.8 million years was obtained. An expansion coefficient in the xz plane with the value Kxz = 135±19 km/s/kpc was also found for them, on the basis of which another age estimate t = 7.2 ± 1.0 million years was obtained. The second sample included 17 stars. The construction of their orbits gave an estimate of age t = 0.2 ± 0.3 million years, and based on the gradient dW/dz = 707 ± 248 km/s/kpc, a second estimate of their age t = 1.4 ± 0.5 million years was obtained. This suggests that the ε Cha association either consists of two groupings of different ages, or a younger one arose as a result of a recent outbreak of star formation within a common star system. The question of the gravitational connection of the groupings has not been considered in the framework of this work.
CRISPR/Cas System Photocontrolled at the Guide RNA Level
Authors: Sakovina L. V , Gorlenko E. S , Novopashina D. S
Published: September 2024

Improving the efficiency and precision of gene editing systems is of utmost importance for modern molecular biology and genetic engineering. Of particular interest is the design of controlled CRISPR/Cas9 systems, the activity of which could be regulated using different physico-chemical stimuli such as light irradiation, pH change, temperature, change of molecule concentration and so forth. A promising direction in this area is the development of approaches to control activity at the level of guide RNA through photosensitive modifications to the structure and sequence of guide RNA, and additional oligonucleotides. This review is devoted to the analysis of publications on design of photosensitive guide RNAs and their applications in genome editing systems using CRISPR.
Azobenzene-Based Voltage-Gated Sodium Channel Blockers with Light-Controlled Local Anesthetic and Antiarrhythmic Activity
Authors: Noev A. N , Kovalenko S. G , Gataulina E. D , Turchaninova E. A , Dzhabrailov V. D , Aitova A. A , Likhobabina D. A , Sutemieva J. A , Frolova S. R , Ruppel L. E , Minakov D. A , Suvorov N. V , Ostroverkhov P. V , Vasil’ev Yu. L , Nikolaev M. V , Tsvelaya V. A , Agladze K. I , Grin M. A
Published: September 2024

The work is devoted to the synthesis of new light-controlled voltage-gated sodium (Nav) channel blockers based on azobenzene and the study of their local anesthetic and antiarrhythmic properties. The effect of ethercaine and two of its new derivatives on native Nav channels was studied in vitro using the patch-clamp method on isolated excitable cells (neurons and cardiomyocytes) of a rat, and local anesthetic activity of the compounds was evaluated on rabbit’s eye cornea. Studies of the effect of the obtained compounds on the conductivity of excitation waves in cardiomyocyte cultures using the optical mapping method were performed. The effective light-dependent biological activity of ethercaine and its derivatives allows us to consider the resulting compounds as potential tools for light-controlled local anesthesia, as well as for non-invasive ablation of arrhythmia in the heart in cardiology.
The Influence of a Combination of Local Moderate Heating and Lighting on the Indicators of Water Metabolism of Intact Parts of Wheat Based on Thermal Imaging
Authors: Popova A. Yu , Zolin Yu. A , Sukhov V. S , Sukhova E. M , Yudina L. M
Published: September 2024

Natural stress factors can lead to yield loss, but when they act locally, stress signals spread, modifying the physiological state and enhancing stress resistance in plants. The purpose of the work is to study the influence of a combination of local factors on indicators of water exchange during irrigation and drought. Wheat was grown in a grow room; drought stress was induced by stopping watering. The modified index of stomatal conductance measured by a thermal camera, leaf water conductivity, and relative leaf water content were used to assess water exchange. It was shown that the conductance index decreased under drought and had strong correlation with plant water status parameters (R > 0.7, p < 0.05). When the plants were watered using a combination of local factors, this led to a decline in the conductance index value versus the one obtained without a stimulus; the response became weaker with increasing distance from the stimulation zone. Soil drought stress reduced the amplitude of index changes. Exposure to local heating or lighting separately did not cause changes in the index of stomatal conductance. The results show that a combination of local heating and lighting stimulates stress signals that reduce water metabolism in wheat. Potentially, such signals may take the form of the electrical signals; however, the lack of changes in the index of stomatal conductance during drought using only local heating does not support this hypothesis.
Paraptosis and Other Types of Non-Apoptotic Regulated Cell Death
Authors: Solovieva M. E , Shatalin Yu. V , Akatov V. S
Published: September 2024

The review is devoted to modern ideas about paraptosis, as one of the types of regulated cell death, in comparison with other types of cell death. Paraptosis is a form of cell death caused by endoplasmic reticulum stress, accompanied by an accumulation of damaged or misfolded proteins, extensive non-autophagic vacuolation of cisterns of endoplasmic reticulum and, in some cases, mitochondria, with subsequent damage to mitochondria, the cytoskeleton, and cell death. The knowledge regarding the molecular mechanisms of paraptosis is of interest for the treatment of cancers resistant to apoptosis-inducing agents.
The Role of Biophysics in Modern Life Sciences
Authors: Ivanitskii G. R
Published: September 2024

This paper provides a list of reviews written by the author and brief overviews of those reviews. In these works, it was shown how biophysics has an effect on the development of life sciences. Biophysics, as systems science, widely uses mathematical modeling methods. The modeling results are important both for the theoretical development of biology and the development of applied sciences such as biomedicine, gerontology, biosafety and robotics.
First record of Zoantharia in the Black Sea: Isozoanthus cf. sulcatus reared from planulae
Authors: Simakova Ulyana V. , Prudkovsky Andrey A. , Lebedeva Tatiana S. , Smorygo Alexandra E. , Moskalenko Viktoria N. , Molodtsova Tina N.
Published: September 2024

The first record of a species from the order Zoantharia in the Black Sea is given. Zoantharians were successfully reared from planktonic larvae collected in a single planktonic net haul conducted in shallow coastal waters of the Golubaya Bay, Gelendzhik area, Caucasus. The larvae were subsequently settled in a small glass container and resulting colonies were maintained in an aquarium with a salinity level of 18 psu for approximately nine months, but in June 2018 all colonies died due to uncontrolled bloom of filamentous algae. The presence of symbiotic algae of the family Symbiodiniacea in tissues of colonies is shown. Phylogenetic analysis using mitochondrial (COI) markers revealed a high degree of similarity between the Black Sea zoantharian and Isozoanthus sulcatus (Gosse 1860) from European seas.
PEMBELAJARAN MENULIS CERITA PENDEK BERORIENTASI PADA PENGEMBANGAN KREATIVITAS PESERTA DIDIK DENGAN MENGGUNAKAN MODEL RADEC (READ, ANSWER, DISCUSS, EXPLAIN, CREATE) DI KELAS XI SMKN 3 BANDUNG TAHUN PELAJARAN 2022/2023
Authors: Wardani Adriansyah Kusuma , Nurhayatin Titin , Puspita Yeni Cania
Published: September 2024

Penelitian ini bertujuan untuk meningkatkan hasil pembelajaran menulis cerita pendek dan kreativitas peserta didik kelas XI SMKN 3 Bandung pada materi pembelajaran menulis cerpen dengan memerhatikan unusr-unsur pembangun. Penelitian ini mendeskripsikan perbedaan kemampuan peserta didik dalam menulis cerita pendek dengan memerhatikan unsur-unsur pembangun antara kelas eksperimen yang menggunakan model RADEC (Read, Answer, Discuss, Explain, Create) dan kelas kontrol yang menggunakan model pembelajaran diskusi serta menguji efektivitas model RADEC (Read, Answer, Discuss, Explain, Create) dalam pembelajaran menulis cerita pendek berorientasi pada pengembangan kreativitas peserta didik. Metode yang digunakan dalam penelitian ini adalah metode eksperimen kuasi dengan bentuk nonequivalent control group design. Teknik pengumpulan data menggunakan teknik studi pustaka, uji coba, observasi dan tes. Data yang dikumpulkan adalah hasil pretest, posttest dan penilaian kreativtias dari kelas eksperimen dan kelas kontrol. Hasil yang diperoleh berdasarkan uji wilcoxon adalah nilai Asymp. Sig. (2-tailed) menunjukkan 0,000 < 0,05 artinya dapat disimpulkan, bahwa terdapat perbedaan kemampuan menulis cerpen yang signifikan antara kelas eksperimen yang menggunakan model RADEC (Read, Answer, Discuss, Explain, Create) dengan kelas kontrol yang menggunakan model diskusi. Adapun hasil dari uji mann whitney adalah Asymp. Sig. (2-tailed) menunjukkan 0,000 < 0,05 artinya model RADEC efektif digunakan dalam pembelajaran menulis cerita pendek.
ANALISIS GAYA BAHASA PADA LIRIK LAGU ROSSA DALAM ALBUM ANOTHER JOURNEY: THE BEGINNING DAN PEMANFAATANNYA SEBAGAI BAHAN AJAR DI SMA
Authors: Aida Nada Nur , Nurhasanah Een , Suntoko Suntoko
Published: September 2024

Hingga saat ini kita dapat dengan mudah mendengarkan lagu melalui aplikasi seperti Youtube Music, JOOX, Spotify, Apple Music, dan lain sebagainya. Pada sebuah lirik lagu terdapat gaya bahasa yang digunakan oleh penyanyi berupa kata-kata kiasan yang membuat lirik lagu tersebut dapat dimaknai dengan indah. Penelitian ini bertujuan untuk mendeskripsikan (1) bentuk gaya bahasa pada lirik lagu Rossa dalam album Another Journey: The Beginning; (2) Hasil penelitian dijadikan sebagai bahan ajar di SMA kelas X. Metode yang digunakan dalam penelitian ini adalah deskriptif analisis. Subjek dalam penelitian ini adalah lirik lagu yang terdapat pada album Another Journey: The Beginning. Teknik pengumpulan data yang digunakan adalah dengan teknik simak catat dan studi pustaka. Penelitian ini menggunakan tiga tahap proses analisis data, yaitu reduksi data, penyajian data dan kesimpulan. Hasil penelitian ini yaitu terdapat 80 gaya bahasa pada lirik lagu Rossa dalam album Another Journey: The Beginning dan gaya bahasa yang paling dominan yaitu gaya bahasa pertentangan anastrof.
KEKERABATAN BAHASA TERINGIN DAN BAHASA KAMPUNG BARU KABUPATEN KOTAWARINGIN BARAT: KAJIAN LINGUISTIK HISTORIS KOMPARATIF
Authors: Fadhila Alfi , Saddhono Kundharu , Suwandi Sarwiji
Published: September 2024

Kajian linguistik komparatif memberikan landasan yang kokoh untuk memahami perubahan dan evolusi dalam bahasa. Tujuan dari kajian linguistik historis komparatif adalah untuk mengetahui fakta dan derajat kekerabatan antarbahasa yang berkaitan erat dengan pengelompokan bahasa-bahasa yang berkerabat dalam kelompok bahasa yang sama. Hubungan kekerabatan sebuah bahasa dapat didefinisikan kata-kata secara statistik kemudian menetapkan pengelompokan bahasa itu berdasarkan persentase Metode penelitian yang digunakan dalam penelitian ini yaitu deskriptif kualitatif dan kuantitatif. Metode kualitatif deskriptif yang dilakukan adalah menentukan pasangan kosakata yang berkerabat identik, pasangan kosakata fonemis, dan pasangan kosakata fonetik. Penelitian ini juga menggunakan metode kuantitatif, yaitu leksikostatistik untuk menghitung presentasi hubungan kekerabatan (cognate). Teknik yang digunakan dalam penelitian ini adalah teknik simak dan catat. Hasil 75% dari perhitungan tersebut menunjukkan bahwa kedua bahasa yaitu Bahasa Teringin dan Bahasa Kampung Baru memiliki hubungan family language (keluarga bahasa). Hal ini menunjukkan bahwa hubungan kekerabatan kedua Bahasa sangat dekat, banyak kosa kata yang sama. Perbedaan lebih terletak pada dialeknya saja. Dari 36 kosakata dasar, didapatkan hasil 27 kata yang memiliki pasangan kerabat (cognate). Di antara 27 kosakata, kata yang berkerabat dengan kategori identik 16 pasang, memiliki korespondensi fonemis 5 pasang, kemiripan secara fonetik 4 pasang, dan tidak berkerabat 9 pasangan.
PENERAPAN STRATEGI METAKOGNISI DAN BERPIKIR KREATIF DALAM MENINGKATKAN KEMAMPUAN MENULIS EKSPOSISI
Authors: Hakim M. Nur , Basri Merri Silvia
Published: September 2024

Penelitian ini bertujuan untuk meningkatkan kemampuan menulis eksposisi melalui penerapan strategi metakognisi dan berpikir kreatif. Penerapan strategi metakognisi dapat melatih kemampuan mahasiswa dalam mengembangkan sebuah tulisan eksposisi dengan memanfaatkan kemampuan berpikir kreatif melalui empat tahapan, yaitu perencanaan, monitoring, pemecahan masalah, dan evaluasi. Jenis penelitian ini menggunakan metode penelitian tindakan. Hasil penelitian terdapat peningkatan pada aktivitas mahasiswa dalam merumuskan ide tulisan, mulai dari perencanaan tulisan, penyusunan draf, pengembangan draf, menghasilkan tulisan yang utuh, hingga publikasi tulisan. Adapun peningkatan juga terdapat pada nilai rata-rata tes awal ialah 59.95, siklus 1 sebesar 71,40, dan meningkat pada siklus 2 sebesar 78.85. dengan demikian dapat disimpulkan bahwa starategi metakognisi dan berpikir kreatif dapat meningkatkan kemampuan menulis eksposisi.
The Role of Nutritional Status in Improving Physical Endurance in Athletes: A Literature Review
Authors: Sandi Samrian , Syahara Sayuti , Firdaus Kamal , Donie Donie , Rahman Dally , Zarya Fiky
Published: September 2024

In the context of modern sports science, understanding the profound impact of nutritional status on athletic performance has become increasingly crucial. This study aims to review the existing literature regarding the role of nutritional status in increasing the physical endurance of athletes. Optimal nutritional status plays an important role in supporting athletic performance through mechanisms involving nutrient intake, energy metabolism, and post-workout recovery. Various studies show that malnutrition can result in decreased physical ability, increased risk of injury, and slow recovery. Conversely, adequate nutrition can improve muscle strength, cardiovascular endurance, and metabolic efficiency. This article summarizes the key findings from various studies that highlight the importance of macro and micro nutrition, hydration, and proper diet planning in supporting athletes' physical endurance. The conclusion of this review underscores that nutritional strategies tailored to the individual needs of athletes are essential to achieve optimal performance and minimize the risk of injury. More research is needed to explore the complex interactions between various nutritional factors and physical fitness components.
Powrót synów marnotrawnych Pułkownik Idzi Kalinowski i jego żołnierze w latach 1623–1624
Authors: Kalinowski Emil
Published: September 2024

The article is a supplement to two parts of the biography of Lisowczycy’s colonel Idzi Kalinowski (? – ca. 1627) published a few years ago. Based on a wide source base, it was possible to establish a number of facts and correct some of the claims of earlier literature. The content of the text discusses the life of this commander against the background of the history of his formation in the years 1623–1624. It covers the period from the enlistment of Kalinowski’s regiment by Emperor Ferdinand II (December 1623) to its return to the Polish-Lithuanian Commonwealth (September 1624).
Bytomskie Państwo Stanowe wobec II wojny północnej
Authors: Baczkowski Aleksander
Published: September 2024

The Bytom State participated indirectly in the Second Northern War as a border country, an area through which the Habsburg armies marched, and a supply base. Based on archival sources, the work presents the situation of the Bytom state between 1655–1660. The described lands experienced war destruction and conflicts between the civilian population and soldiers. These events led to a deepening crisis resulting from the Thirty Years’ War.
„Zielone Diabły” na gruzach Festung Breslau. Niemieccy spadochroniarze w walkach o Wrocław w 1945 roku
Authors: Cielecki Jacek
Published: September 2024

The article discusses the use of German parachute units in the battle for Breslau (modern day Wrocław) in 1945, which has not been widely studied to date. The research was based on available and lesser-known German, Russian and Polish archives. The study also presents the memories of German paratroopers and staff documents.
„Trudno jest teraz pracować regularnie, gdyż bez przerwy są naloty” Obraz kryzysu sueskiego z 1956 r. z perspektywy Attachatu Wojskowego przy Ambasadzie Polskiej Rzeczpospolitej Ludowej w Kairze
Authors: Benken Przemysław , Centek Jarosław
Published: September 2024

This article analyzes the information sent by the military attaché at the Embassy of the Polish People’s Republic in Cairo during the Suez Crisis of 1956. The documents in question, which are now stored in the Archive of the Institute of National Remembrance in Warsaw, were initially sent to the appropriate cells of the operational department of the 2nd Directorate of the General Staff of the Polish army. The information provided by the attaché constituted one of the most important sources of knowledge for the decision-makers in Warsaw regarding the course of events in the Middle East.
Distinct and Overlapping Metabolites Associated with Visual Impairment and Cognitive Impairment
Authors: Hu Wenyi , Chu Tiancheng , Liao Huan , Wang Wei , Ha Jason , Kiburg Katerina , Zhang Xiayin , Shang Xianwen , Huang Yu , Zhang Xueli , Tang Shulin , Hu Yijun , Yu Honghua , Yang Xiaohong , He Mingguang , Zhu Zhuoting
Published: September 2024

Background:

Previous studies found that visual impairment (VI) is associated with higher risk of cognitive impairment, but the molecular basis of these conditions is unknown.

Objective:

We aim to compare the metabolite associations of VI and cognitive impairment.

Methods:

The study population with comprehensive measurements was derived from the UK Biobank study. Visual acuity worse than 0.3 logMAR units were defined as VI. Failure in one or more of the four cognitive tests was defined as cognitive impairment. A panel of 249 metabolites was measured using a nuclear magnetic resonance metabolites profiling platform. Logistic regression models were applied to compare metabolite associations with VI and cognitive impairment.

Results:

23,775 participants with complete data on visual acuity, cognitive tests and metabolomics, and without a history of neurological disorders at baseline were included. After adjusting for confounding factors, VI was significantly associated with cognitive impairment (odds ratio[OR] = 1.49, 95% confidence interval [CI]: 1.27–1.74, p < 0.001). After multiple testing correction ( p < 9×10–4), five metabolites including the ratio of omega-6 to omega-3 fatty acids (FAs) (OR = 1.18[1.10–1.27]), ratio of omega-3 to total FAs (OR = 0.84[0.77–0.91]), ratio of docosahexaenoic acid (DHA) to total FAs (OR = 0.86[0.80–0.94]), DHA (OR = 0.85[0.78–0.92]), and omega-3 FAs (OR = 0.84[0.77–0.91]) were uniquely associated with VI. Glycoprotein acetyls (OR = 1.06[1.03–1.10]) and alanine (OR = 0.95[0.92–0.98]) were exclusively associated with cognitive impairment. Albumin was identified as the common metabolite shared by the two phenotypes (OR = 0.90[0.85–0.95] for VI, and 0.95[0.92–0.98]) for cognitive impairment).

Conclusions:

We identified distinct and overlapping metabolites associated with VI and cognitive impairment, unveiling their distinct metabolic profiles and potential common pathophysiology.
Combining Biomarkers with Genetics In Prodromal/Earliest Phase Parkinson’s Disease
Authors: Seibler Philip , Streubel-Gallasch Linn , Klein Christine
Published: September 2024

Family studies have linked several rare genetic variants to hereditary forms of Parkinson’s disease (PD). In addition to these monogenic forms, many PD cases are associated with genetic risk factors. Asymptomatic individuals carrying pathogenic variants linked to PD are at risk of developing the disease later in life, thereby providing a unique opportunity for the detection of the earliest pathophysiological and later clinical changes and, importantly, also of protective and compensatory features and mechanisms. However, the rarity of monogenic PD-causing variants is a major challenge of this approach. In this review, we discuss recent advances in the search for biomarkers in the prodromal/earliest phase of genetically linked PD.
THE IMPACT OF STRESS MANAGEMENT FOR URBAN MUSLIMS: INCREASING THE RESILIENCE OF SURVIVORS OF THE KANJURUHAN TRAGEDY
Authors: Mahmudah Siti , Astutik Fuji , Khoirot Umdatul , Safitri Rini
Published: September 2024

One of the impacts of a disaster or tragedy is the presence of trauma after the event or a mental state that is shaken so that it is unable to survive with a healthy mentality. This research aims to help Muslim urban communities who are victims of the Kanjuruhan tragedy through the provision of the Impact of stress management to increase resilience. In this study, the researcher used a quantitative approach with the quasi-experimental method of one group pretest post-test to test the effect of treatment before and after treatment. The participants were 19 (3 victims were directly affected, and 16 were indirectly affected). Data were collected through questionnaires before and after the administration of treatment, as well as long-term monitoring. The results showed a significant difference in participants’ resilience levels before and after being given the Impact of stress management. The effect size caused by these activities is relatively large when viewed from the average resilience ratio before and after activities. Likewise, the significance test that shows a significant impact is shown by a significance number of 0.000, which is < out of 0.05. This study concludes that the Impact of stress management is practical and has a significant effect on increasing the resilience of the participant.
Reunification of Germany and Perceptions of its History
Authors: Houžvička Václav
Published: September 2024

Richard J. Evans: Rereading German History /1800-1996 From Unification to Reunification/. Routledge, London/New York 1997, 256 stran, ISBN 0-415-15900-8.
FAKTOR PENGHAMBAT PENYIDIKAN KORUPSI ANGGARAN DESA DI DESA BATU API KECAMATAN BATU PUTIH KABUPATEN KOLAKA UTARA
Authors: Irabiah Irabiah , Utomo Puji Prio , Ahmad Rosman
Published: September 2024

Kasus korupsi dalam pengelolaan Anggaran Pendapatan dan Belanja Desa (APBDesa)  di Desa Batu Api, Kecamatan Batu Putih, Kabupaten Kolaka Utara, Sulawesi Tenggara, terjadi pada Tahun Anggaran 2015 dan 2016 dengan pelaku utama pejabat sementara kepala desa dibantu bendahara desa.  Penelitian ini bertujuan mengetahui faktor-faktor penghambat penyidikan korupsi pada pengelolaan APBDesa di Desa Batu Api. Penelitian hukum empiris ini dilaksanakan di Mapolres Kolaka Utara dengan informan penyidik Sat Reskrim Polres Kolaka Utara dan pejabat Pemerintah Kabupaten Kolaka Utara yang terkait dengan kajian masalah. Penulis juga melakukan studi dokumentasi melalui data-data penyidik Polres Kolaka Utara, dilengkapi studi kepustakaan dari artikel ilmiah, media online, buku serta peraturan berlaku.  Kesimpulan, kendala teknis penyidikan adalah tersangka tidak kooperatif, waktu kejadian berselang lama, serta kesulitan pencarian dokumen barang bukti dan pelacakan uang hasil korupsi. Adapun kendala nonteknis adalah  kondisi geografis Desa Batu Api yang terpencil, kondisi masyarakat yang kurang membantu penyidik, serta terbatasnya ahli di wilayah Kabupaten Kolaka Utara.
PERTIMBANGAN HAKIM TENTANG PERBUATAN MELAWAN HUKUM PERJANJIAN BAKU ANTARA KONSUMEN DENGAN PT. BCA FINANCE CABANG BANDAR LAMPUNG
Authors: Fadel Wildinata Muhammad Ilham , B Erlina , Nurina Intan
Published: September 2024

Tulisan ini menganalisis faktor penyebab terjadinya perbuatan melawan hukum dalam isi klausula baku oleh PT. BCA Finance Cabang Bandar Lampung, berdasarkan Putusan Nomor: 51/Pdt.G/2023/PN TJK. Metode penelitian Hukum dalam hal ini merupakan suatu ilmu tentang cara melakukan penelitian hukum dengan teratur (sistematis). Hubungan hukum antara Tergugat dan Penggugat terkait fasilitas pembiayaan pembelian kendaraan bermotor menjadi fokus penelitian. Setelah analisis kelayakan, Tergugat menyetujui dan merealisasikan permohonan pembiayaan, yang diatur dalam Perjanjian Pembiayaan Konsumen. Meski sah menurut hukum, Penggugat wanprestasi dengan tidak membayar angsuran sejak Februari 2023, memicu penilaian hakim berdasarkan Pasal 10 tentang Kejadian Kelalaian dan Akibatnya. Penelitian juga mempertimbangkan dasar pertimbangan hakim dalam memutus perkara perbuatan melawan hukum isi klausula perjanjian baku antara PT. BCA Finance Cabang Bandar Lampung dengan konsumen, berdasarkan Putusan Nomor: 51/Pdt.G/2023/PN TJK. Hakim, sebagai pelaku utama fungsi pengadilan, memiliki tanggung jawab untuk menegakkan hukum dan keadilan.
KARTU IDENTITAS ANAK: PELAKSANAANNYA PADA DINAS KEPENDUDUKAN DAN CATATAN SIPIL KABUPATEN BANGGAI KEPULAUAN
Authors: Shahib Pitriasari , Marzuki Abdul Ukas , Mina Risno , Labatjo Ridwan , Hipan Nasrun
Published: September 2024

Penelitian ini bertujuan untuk mengetahui pelaksanaan penerbitan Kartu Identitas Anak pada Dinas Kependudukan dan Catatan Sipil Kabupaten Banggai Kepulauan dan upaya yang dilakukan. Dalam penelitian ini metode penelitian yang digunakan yaitu Jenis penelitian yuridis empiris, yang merupakan jenis penelitian hukum sosiologis. Pelaksanaan Penerbitan Kartu Identitas Anak pada Dinas Kependudukan dan Catatan Sipil Kabupaten Banggai Kepulauan dilakukan melalui pendaftaran oelh orang tua melibatkan pengumpulan dokumen-dokumen seperti akta kelahiran anak, Kartu Keluarga (KK), dan dokumen identifikasi orang tua atau wali. Apabila berkas persyaratan sudah lengkanp dilakukan proses penerbitan dan penandatanganan Kartu Identitas Anak (KIA). Selanjutnya KIA diberikan kepada orang tua langsung atau melalui pemerintah kecamatan atau desa. Adapun Upaya yang dilakukan oleh Dinas Kependudukan dan Catatan Sipil Kabupaten Banggai Kepulauan untuk meningkatkan penerbitan Kartu Identitas Anak, meliputi sosialisasi dan edukasi, Peningkatan Aksesibitas atau Akses, penyederhanaan prosedur, dan kerjasama dengan instansi terkait.
A vasúti határforgalom-ellenőrzés története 1875-től 1919-ig
Authors: Bartus Gábor
Published: September 2024

A rendőrség határrendészeti szolgálati ágának tevékenysége rendkívül szerteágazó és sokrétű, amelyek között kiemelkedő szerepet játszik a határforgalom-ellenőrzés és ennek egy speciális formája, a vasúti határforgalom-ellenőrzés. A rendészettudomány területén kevés tanulmány foglalkozik a határforgalom-ellenőrzés kialakulásával, jelen tanulmány az első határállomások kialakításának körülményeit tárja fel, eredményei hozzájárulnak a hagyományok ápolásához. A tanulmányban koherens, logikus felépítés mentén tárom fel a vasúti határforgalom-ellenőrzés gyökereit és hagyományait, amelyek a határrendészeti feladatok szerves részét képezik, így a rendészettörténetnek és a rendészettudománynak is. Az összefüggések vizsgálata során kiemelt figyelmet kapnak az interdiszciplináris kapcsolódási pontok a rendészettudomány és közlekedéstudomány oldaláról. A közlekedési infrastruktúra fejlődése az államhatár elérésével ok-okozati összefüggésként maga után vonta a vasúti pályarendszer kiépítésének olyan rendészeti tevékenységét, amely eltért a korábban jellemző, hagyományosan értelmezett határőrizettől. Leíró jellegű kutatást végeztem az elsődleges és másodlagos források kutatásával és elemzésével, az ismert tudományos eredmények és információk összehasonlításával. A vasúti határforgalom-ellenőrzés kialakulását alapvetően determinálták az általam elemzett korszakban végbemenő változások. A vasúti közlekedési infrastruktúra fejlődése és az államhatár elérése, az államhatárok pontos megállapítása és kijelölése, az államhatáron átmenő vasúti összeköttetés helyeinek pontos meghatározása és nemzetközi egyezményben ratifikálása, a feladatokat ellátó szervezeti keretek mind-mind olyan fontos és nélkülözhetetlen elemek, amelyek időbeni és térbeni együtt állása nélkül nem beszélhetünk vasúti határforgalom-ellenőrzésről.
Exploring Teaching Assistants’ Potential to Facilitate Multicultural Group Work in a Multicultural Undergraduate Classroom in Japan
Authors: Kimura Rikio
Published: September 2024

Despite the needs for the facilitation for multicultural group work (MCGW) in classrooms in internationalized higher education, research on teaching assistants’ (TAs) potential to facilitate MCGW has been lacked. This mixed-method study examined how a course design for activating MCGW, which strategically engaged TAs, influenced the social dynamics of MCGW and students’ learning outcomes in an English-taught undergraduate course at a standalone international university in Japan. The results revealed that both Japanese and international students made group work inclusive and international students demonstrated altruistic attitudes for Japanese students with foundational English skills. Students expressed their views in their groups and increasingly bore responsibility for group tasks, but not to the extent that everyone in the group equally expressed their views and bore an equal share of the responsibility. Meanwhile, the percentage of students receiving lower grades decreased. Therefore, the course design positively affected the group dynamics and students’ learning outcomes.
The Ethics of Research and Teaching in an Age of Big Data
Authors: Lundie David
Published: September 2024

Big Data, understood as high-volume, high-velocity and/or high-variety information assets that enable insight, decision-making, and process automation (Gartner, 2015), offers both opportunities and challenges in all aspects of human life. As Higher Education serves as preparation not only for economic but also for health, welfare, social and civic participation, these changes are imbricated in many aspects of academic endeavor.
In relation to research ethics, this change represents a normative difference in degree rather than a difference in kind. Data is more messy, more rapid, more difficult to predict and more difficult to identify owners, but the principles of informed consent, confidentiality and prevention of harm apply equally to digital as to traditional research data. Central to applying these principles, however, is the recognition that technologies are not inherently value neutral, and that data collection, aggregation, and its use in decision making can both create and intensify inequities and harms. A data justice approach to research ethics extends concern with voice and authenticity into the digital domain.
The transparency and ethics of our research processes have wider significance, as they determine the creation of new knowledge, and the processes by which this is disseminated to students. Universities provide an important role as gatekeepers to professional accreditation in a number of fields, including software engineering, and the relation between academic freedom of enquiry, state and corporate interests in the Big Data age raises important questions about power and control in the academy, which in turn have implications for the norms of research governance.
Digitalization of Higher Education in Ethiopia
Authors: Adamu Abebaw Yirga
Published: September 2024

This paper examines the digitalization of higher education in Ethiopia. It mainly focuses on better understanding the policies, practices, and challenges of digitalization of higher education in the country. The necessary data were mainly generated from continental, national, and institutional policy and strategy documents. Publicly available transnational and national reports and other documents and the author’s views and lived experiences were also used to substantiate data generated through policy review. The data were analyzed using deductive thematic analysis. The themes were mainly developed based on prior research and existing literature. The findings indicate that there are sufficient and feasible policies and strategies to promote and ensure the digitalization of higher education in Ethiopia. The findings also reveal that there are initiatives that promote the practice of digitalization of higher education. However, poor internet connection, lack of adequate ICT infrastructure, lack of skilled human resources, and staff resistance to change were found to be the major barriers to enhancing the digitalization of higher education in Ethiopian higher education. The results imply that having feasible policies and strategies is a necessary but insufficient condition to ensure effective implementation of digitalization of higher education. It necessitates the government’s commitment as well as a shift in focus from the expansion of HEIs, which was the case in the last two decades, to ensuring the quality and relevance of HEIs through digital transformation.
Achieving Access and Equity in Education: An Analysis of Higher Education Reforms in Pakistan
Authors: Rind Gul , Malin Joel R.
Published: September 2024

In the past two decades, the Government of Pakistan has significantly invested in higher education (HE) to bring structural reforms in funding, governance, and quality assurance mechanisms. Their overarching mission has been to fuel national socioeconomic development by ensuring equal access to HE. Given this, the present study aimed to address the following research question: To what extent have current HE reforms in Pakistan enabled equitable access to HE? To address this question, this study drew from a social justice-centered framework to track trends in HE access that is, broadly and based on socio-economic status, gender, urbanicity/rurality, and region/province. Using secondary data from diverse sources including the HEC, Academy of Education Planning and Management, and the Pakistan Poverty Alleviation Fund, we conducted descriptive longitudinal analyses. Findings underscore that the system has failed to provide equal access to HE in several ways and discuss some possibilities for policymakers in equalizing the opportunities.
Effect of processing and storage on the quality of the purees made from different sweet
potato cultivars
Authors: Lončarić Ante , Zec Zrinušić Sanja , Kovač Tihomir , Bilić Rajs Blanka , Lončarić Melita , Jozinović Antun , Babić Jurislav
Published: September 2024

This study aimed to elucidate the effects of processing and storage on the nutritional and antioxidant properties of three sweet potato cultivars from Croatia. The sweet potato purees (SPP) were analyzed for proximate composition and properties, antiradical activity (AA), total phenolic content (TPC), starch content, free sugars (FS), β-carotene, total anthocyanins (TA), and color. The highest TPC (2.55 µg GAE/mg) and starch content (596.9 g/kg DW) are in the purple cultivar, while the highest AA (21.76 mol TE/g) and total and reducing sugars (50.7 and 30.9 g/kg, respectively) were in the white cultivar. During processing, the sucrose, glucose, and fructose content decreased, leading to an increase in maltose content. The AA, TPC, and FS were higher in baked and steamed SPP, while the starch, β-carotene, and TA contents were lower. These results suggest that processing can enhance some of the properties (TPC, AA, and reducing sugars) of sweet potatoes making a processed sweet potato a desirable food ingredient with physio-chemical and nutritional attributes that has a future beyond home usage for the production of safe processed functional foods. Storage resulted in a decrease in AA, β-carotene, and TA, while TPC, starch, and soluble solids were stable during 6 months of storage.
Utjecaj vremena skladištenja na aromatični profil djevičanskih maslinovih ulja
Authors: Šarolić Mladenka , Pitarević Anita , Marijanović Zvonimir , Knezović Zlatka
Published: September 2024

Djevičansko maslinovo ulje se za razliku od većine biljnih ulja dobiva pomoću niza mehaničkih tehnoloških operacija kojima je svrha izdvojiti nastale kapljice ulja u stanicama pulpe ploda maslina. Dobiveno ulje je prirodno stvorena masnoća u plodu masline i odlikuje se jedinstvenim kemijskim sastavom i specifičnom ugodnom aromom. Zato se može konzumirati izravno bez ikakvog daljnjeg rafinacijskog tretmana. Cilj ovog rada bio je utvrditi kako vrijeme skladištenja utječe na aromatični profil djevičanskog maslinovog ulja. Istraživanje je provedeno na tri uzorka ekstra djevičanskog maslinovog ulja, nakon prerade te svaka tri mjeseca u periodu od godine dana čuvanja u zatvorenoj tamnoj staklenoj boci, na suhom i tamnom mjestu pri sobnoj temperaturi. U ovom radu izolacija hlapljivih spojeva ulja provedena je mikroekstrakcijom vršnih para na krutoj fazi (HS-SPME) korištenjem sivog vlakna s DVB/CAR/PDMS ovojnicom. Analiza izoliranih hlapljivih spojeva provedena je spregnutom tehnikom plinske kromatografije-masene spektrometrije (GC-MS). Identificirani hlapljivi spojevi pripadaju sljedećim kemijskim skupinama: aldehidi, alkoholi, ketoni, kiseline, alifatski ugljikovodici i terpeni. Među hlapljivim spojevima dominantni su bili aldehidi, a najzastupljeniji spoj u svim uzorcima bio je (E)-heks-2-enal koji je okarakteriziran mirisom na zelenu i svježe pokošenu travu. Dobiveni rezultati ukazali su na promjene u aromatičnom profilu djevičanskih maslinovih ulja tijekom vremena skladištenja. Uglavnom su se odnosile na smanjenje udjela C-6 aldehida (E)-heks-2-enala te rast udjela C-6 alkohola (heksanola) odgovornih za „zelene“ i svježe note.
Fizikalno-kemijske značajke ploda trešnje sorte Isabella i Prima Giant uzgajanih na različitim tlima
Authors: Šupljeglav Jukić Aleksandra , Aliman Jasmina , Hasanbegović Sejfić Jasna
Published: September 2024

U razdoblju dvije godine (2019, 2020) proučavane su fizikalne i kemijske osobine ploda dvije sorte trešnje (Isabella i Prima Giant) cijepljene na podlozi Saint Lucie 64 u agroekološkim uvjetima submediteranske Hercegovine na tri različita tipa tla na lokalitetima: Blagaj, Konjusi i Aladinići. Istraživanja su obuhvaćala analizu mase ploda i koštice, dužinu peteljke, dimenzije ploda, sadržaj ukupnih kiselina i ukupnih šećera. Rezultati su pokazali da je sorta Prima Giant u 2020. godini imala najveću prosječnu vrijednost za sve promatrane fizikalne parametre ploda (masu ploda i koštice, dužinu peteljke, širinu ploda). Sorta Isabella je u 2019. godini imala najveću prosječnu masu koštice i dužinu peteljke, dok su plodovi sorte Prima Giant imali najveću prosječnu masu, dužinu, širinu i debljinu ploda. Na osnovu dobivenih vrijednosti, sorta Prima Giant je pokazala bolje rezultate fizikalnih osobina ploda u odnosu na sortu Isabella. Sorta Isabella je imala najveću prosječnu vrijednost ukupnih šećera i kiselina.
New data on the distribution of Adiantum capillus-veneris L. in Bosnia and Herzegovina
Authors: Maslo Semir , Šarić Šemso , Milanović Đorđije
Published: September 2024

This paper is a survey of distribution of Adiantum capillus-veneris L. in Bosnia and Herzegovina based on a revision of herbarium material from SARA and ZA collections, literature data and field observations. In addition, a brief morphological description, distribution map and photographs of the species are presented. The aim of the paper is to describe the current distribution of the species in the territory of Bosnia and Herzegovina based on new field research conducted in the last 20 years. It was established that the species is present in nineteen UTM quadrants in Bosnia and Herzegovina, three of which are reported for the first time for the area. On the other hand, the presence of the species was confirmed at the locality of Vranduk in central Bosnia, where it was previously stated that it had disappeared. In the territory of Bosnia and Herzegovina this species is relatively common in the Mediterranean part of the country, especially in the Neretva valley, while in the continental part of the country it is recorded only in four localities, mostly near thermal springs.
МЕТОДИЧНІ ЗАСАДИ МАРКЕТИНГОВИХ ДОСЛІДЖЕНЬ
Authors: Корнійчук Тимофій , Луцій Іван
Published: September 2024

У статті розглянуто та обґрунтовано важливість маркетингових досліджень у стратегічному плануванні та при здійсненні ринкової діяльності підприємств. Дослідження проведено на тлі сучасних теоретичних підходів у сфері маркетингу та дослідницьких практик, що стосуються збору та аналізу даних. Завдяки комплексному підходу та практичній спрямованості, стаття є корисним джерелом інформації для фахівців з маркетингу та менеджменту, а також для студентів, які проводять дослідження на цієї дисципліни. Стаття спрямована на формування розуміння у читачів важливості маркетингових досліджень для прийняття обґрунтованих стратегічних рішень, зокрема у розробці продуктів, ціноутворенні, рекламі та дистрибуції. Різноманітні підходи до визначення суті маркетингових досліджень висувають широкий спектр методів, від кабінетних до польових пошуків інформації, а також новітні інформаційні технології, такі як аналітика даних соціальних мереж і VR.