bluuebunny/crossref_metadata_2025 huggingface dataset:
A Chromosome-Scale Genome of Trametes versicolor and Transcriptome-Based Screening for Light-Induced Genes That Promote Triterpene Biosynthesis
Authors: Yang Yang , Hu Xuebo
Published: January 2025

Trametes versicolor is an important fungus with medicinal properties and a significant role in lignocellulose degradation. In this study, we constructed a high-quality chromosome-level genome of T. versicolor using Illumina, PacBio HiFi, and Hi-C sequencing technologies. The assembled genome is 47.42 Mb in size and contains 13,307 protein-coding genes. BUSCO analysis revealed genome and gene completeness results of 95.80% and 95.90%, respectively. Phylogenetic analysis showed that T. versicolor is most closely related to T. pubescens, followed by T. cinnabarina and T. coccinea. Comparative genomic analysis identified 266 syntenic blocks between T. versicolor and Wolfiporia cocos, indicating a conserved evolutionary pattern between the two species. Gene family analysis highlighted the expansion and contraction of genes in functional categories related to the biosynthesis of secondary metabolites, including several T. versicolor-specific genes. Key genes involved in lignocellulose degradation and triterpene production were identified within the CAZyme and CYP450 gene families. Transcriptomic analysis under dark and light conditions revealed significant changes in the expression of genes related to secondary metabolism, suggesting that light signals regulate metabolic pathways. A total of 2577 transporter proteins and 2582 membrane proteins were identified and mapped in the T. versicolor genome, and 33 secondary metabolite gene clusters were identified, including two light-sensitive triterpene biosynthesis clusters. This study offers a comprehensive genomic resource for further investigation into the functional genomics, metabolic regulation, and triterpene biosynthesis of T. versicolor, providing valuable insights into fungal evolution and biotechnological applications.
Spatial Reconstruction and Determinants of Industrial Land in China’s Urban Expansion: A Theoretical Framework
Authors: Zhao Dan , Liu Kewei , Li Jianwei , Zhai Jiagang
Published: January 2025

The evolution of industrial land layout is a significant feature of changes in urban land use types during rapid urbanization. However, the theoretical studies investigating the evolution mechanism behind industrial land are scarce. This study developed a dynamic theoretical framework examining the relationship between government and market forces. Furthermore, this study examined the determinants of industrial land evolution in Xi’an from 1994 to 2019 by using a logistic regression model. The results showed that industrial land area increased from 55.02 km2 to 126.63 km2 from 1994 to 2013 but later rapidly reduced to 106.61 km2 in 2019. The spatial distribution of industrial land exhibited significant deindustrialization and suburbanization during park-orientated agglomeration and showed a shift from large-area small-patch to multi-center large-patch agglomeration. Factors such as development zone policies, land prices, agglomeration benefits, land supply, and transportation infrastructure are key determinants of suburbanization, while land prices and agglomeration benefits are key determinants of deindustrialization. This study reveals the mechanisms driving industrial land evolution and offers guidance in improving the rationality of urban land layout and achieving industry–city integration.
Inherited Hypertrabeculation? Genetic and Clinical Insights in Blood Relatives of Genetically Affected Left Ventricular Excessive Trabeculation Patients
Authors: Mester Balázs , Lipták Zoltán , Farkas-Sütő Kristóf Attila , Grebur Kinga , Gyulánczi Flóra Klára , Fábián Alexandra , Fekete Bálint András , György Tamás Attila , Bödör Csaba , Kovács Attila , Merkely Béla , Szűcs Andrea
Published: January 2025

Genetically determined left ventricular excessive trabeculation (LVET) has a wide clinical spectrum ranging from asymptomatic subjects to severe heart failure with arrhythmias and thromboembolic events. Unlike other cardiomyopathies, the relatives of LVET patients never reach the spotlight of guidelines and clinical practice, although these family members can be often affected by these conditions. Thus, we aimed to investigate the relatives of LVET by multidimensional analysis, such as genetic testing, ECG and cardiac ultrasound (ECHO). We included 55 blood relatives from the family of 18 LVET patients (male = 27, age = 44 ± 20.8y), who underwent anamnesis registration. With Sanger sequencing, the relatives were classified into genetically positive (GEN-pos) and unaffected (GEN-neg) subgroups. In addition to regular ECG parameters, Sokolow-Lyon Index (SLI) values were calculated. 2D ECHO images were analysed with TomTec Arena, evaluating LV volumetric, functional (EF) and strain parameters. Individuals were categorized into JENNI-pos and JENNI-neg morphological subgroups according to the Jenni LVET ECHO criteria. Family history showed frequent involvement (arrhythmia 61%, stroke 56%, syncope 39%, sudden cardiac death 28%, implanted device 28%), as well as personal anamnesis (subjective symptoms 75%, arrhythmias 44%). ECG and ECHO parameters were within the normal range. In terms of genetics, 78% of families and 38% of relatives carried the index mutation. LV_SLI and QT duration were lower in the GEN-pos group; ECHO parameters were comparable in the subgroups. Morphologically, 33% of the relatives met Jenni-LVET criteria were genetically affected and showed lower LV_EF values. The frequently found genetic, morphological and clinical involvement may indicate the importance of screening and, if necessary, regular follow-up of relatives in the genetically affected LVET population.
Application of a Mixture of Fly Ash and Solid Waste from Gas Treatment from Municipal Solid Waste Incineration in Cement Mortar
Authors: Pietrzak Alina , Ulewicz Malgorzata , Kozień Ewa , Pietraszek Jacek
Published: January 2025

This paper analyzes the effective use of a mixture of fly ash (MSWI-FA) and solid waste from flue gas treatment (MSWI-SW), which are by-products of the municipal waste incineration process. MSWI-FA (19 01 13*) and MSWI-SW (19 01 07*) are classified as hazardous waste due to their toxic metal content and leaching potential, and currently lack practical applications, unlike slag and bottom ash (19 01 12). This study tested these wastes as partial substitutes for natural sand within a range of 0–20% of cement mass. Statistical analysis of the experimental results allowed the creation of good quality models predicting the effect of substitution additives on compressive strength and flexural strength (correlation 0.91 and 0.93, respectively). The mixture with the highest share of substitution additives (40% = 20% + 20%) was characterized by a decrease in compressive strength by 1.3% and flexural strength by 25.8%. Cement mortars synthesized with the waste mixture (up to 20% of each component) showed slightly lower consistency and water absorption than the control mortars. After the frost resistance tests (25 cycles), the flexural and compressive strength showed ambiguous behavior, showing both increases and decreases, indicating that the percentage of waste components alone is an insufficient set of factors for predicting these strength properties. The concentration of metal ions, i.e., Zn, Cu, Pb, Ni, Cu, and Cr, in the eluate after the leaching tests did not exceed the legal levels of pollutants introduced into waters, with the exception of barium. However, its content did not exceed the permissible levels required for waste intended for landfill. Using the mixing plant for this waste in the amount of 20% each, we save about EUR 10 in the cost of purchasing sand (which is 13% of the production costs of 1 m3) and EUR 8 in the cost of environmental fees when producing 1 m3 of mortar. The proposed technology is compatible with the objectives of a sustainable economy.
Bond Performance of GFRP Bars in Glass and Basalt Fiber-Reinforced Geopolymer Concrete Under Hinged Beam Tests
Authors: Ertürkmen Duygu , Ürünveren Hüsamettin , Beycioğlu Ahmet , Ibadov Nabi , Aruntaş Hüseyin Yılmaz , Garbacz Andrzej
Published: January 2025

In recent years, researchers have focused on the usability of fiber-reinforced polymer (FRP) bars due to their lightweight, corrosion-resistant, and eco-friendly characteristics. Geopolymers, as low-carbon alternatives to traditional binders, aim to reduce CO2 emissions in concrete production. The bond strength between FRP bars and concrete is critical for the load-bearing capacity and deformation characteristics of reinforced elements. The objectives of this work are to investigate the bond performance of GFRP bars in chopped glass and basalt fiber-added geopolymer concrete using hinged beam tests. Since the hinged beam test accurately represents the behavior of real bending elements, this test method was selected as a main bonding test. Initially, three geopolymer mixtures with Ms modulus values of 1.2, 1.3, and 1.4 were prepared and tested. The mixture with a modulus of 1.2 Ms, achieving a compressive strength of 56.53 MPa, a flexural strength of 3.54 MPa, and a flow diameter of 57 cm, was chosen for beam production due to its optimal workability and strength. After mechanical and workability tests, SEM analysis was performed to evaluate its internal structure. For evaluating the bond performance of GFRP bars, 12 geopolymer beam specimens were prepared, incorporating varying fiber types (chopped glass fiber or basalt fiber) and embedment lengths (5 Ø or 20 Ø). Hinged beam tests revealed that the bond strengths of glass and basalt fiber-added mixtures were up to 49% and 37% higher than that of the control geopolymer concrete, respectively. It was concluded that incorporating fibers positively influenced the bond between geopolymer concrete and GFRP bars, with glass fibers proving more effective than basalt fibers. These findings enhance the understanding of bond mechanisms between GFRP bars and geopolymer concrete, emphasizing their potential for sustainable and durable construction in both industrial and scientific applications.
A Note on Mutation Equivalence
Authors: Liu Siyang , Pan Jie
Published: January 2025

We focus on the necessary conditions for two totally sign-skew-symmetric matrices B and B′ to be mutation equivalent, obtaining two specific conditions: the equality of their column greatest common divisor vectors and the equality of |B| and |B′|, up to a relabeling of indices, when both matrices are acyclic. As a byproduct, the former condition confirms a conjecture on cluster automorphisms for totally sign-skew-symmetric cluster algebras.
Management of High Urogenital Sinus in Adults: A Scoping Review
Authors: Hammad Muhammed A. Moukhtar , Samaan Nardeen Magdy , Ghoniem Gamal
Published: January 2025

Background and Objectives: Persistent urogenital sinus (PUGS) is a rare congenital anomaly resulting from disruptions in urogenital development during embryogenesis. Characterized by the confluence of the vaginal canal and urethra into a single channel, it poses diagnostic and management challenges, particularly in adult patients. Surgical correction remains the primary treatment at an early age, yet there are no universally accepted guidelines regarding treatment at later stages in life. We explored current evidence on the management of high urogenital sinus (HUGS) in adults, focusing on surgical techniques, outcomes, perioperative care, and follow-up. Materials and Methods: A scoping review was conducted using PubMed, Scopus, and Google Scholar, including studies published up to August 2024. Search terms included “high urogenital sinus”, “adult patients”, and related conditions. Articles were included if they addressed clinical, diagnostic, or therapeutic data on HUGS in adult populations. Data extraction was performed independently by two reviewers, and a PRISMA-ScR flow diagram was used to outline the study selection process. Results: Nine studies met inclusion criteria, with data on surgical techniques, perioperative care, and long-term outcomes extracted for analysis. The included studies highlighted diverse surgical approaches, such as feminizing genitoplasty, buccal mucosa vaginoplasty, posterior prone techniques, and robotic-assisted urogenital sinus mobilization. Complications like vaginal stenosis, urethrovaginal fistula, and urinary incontinence were reported. Long-term outcomes were under-reported, with limited data on sexual function and patient satisfaction. Hormonal therapies, including glucocorticoids, played critical roles in managing cases associated with congenital adrenal hyperplasia (CAH). Conclusions: The management of HUGS requires a multidisciplinary approach integrating advanced surgical techniques and individualized perioperative care. While short-term outcomes are generally favorable, long-term data on sexual function and quality of life remain scarce. Future research should prioritize longitudinal studies to address these gaps, aiming to optimize surgical outcomes, patient satisfaction, and psychosocial well-being.
Effects of Selected Food Additives on the Gut Microbiome and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Authors: Jarmakiewicz-Czaja Sara , Sokal-Dembowska Aneta , Filip Rafał
Published: January 2025

The purpose of this article is to present selected food additives as disruptors of normal intestinal homeostasis with a potential impact on the development of metabolic dysfunction-associated steatotic liver disease (MASLD). A comprehensive literature search was conducted in three major electronic databases: PubMed, ScienceDirect, and Google Scholar. MASLD is a prevalent liver condition that is closely related to the global rise in obesity. Its pathogenesis is multifactorial, with genetic, environmental, and metabolic factors playing a key role. The “multiple-hit” hypothesis suggests that a Western-style diet, rich in ultra-processed foods, saturated fats, and food additives, combined with low physical activity, contributes to obesity, which promotes lipid accumulation in the liver. Recent studies underscore the role of impaired intestinal homeostasis in the development of MASLD. Food additives, including preservatives, emulsifiers, and sweeteners, affect gut health and liver function. Selected preservatives inhibit pathogenic microorganisms but disrupt the intestinal microbiota, leading to changes in intestinal permeability and liver dysfunction. Some emulsifiers and thickeners can cause inflammation and alter the gut microbiome, contributing to liver steatosis. Furthermore, the use of sweeteners such as sucralose and aspartame has been linked to changes in liver metabolism and intestinal microbial composition, which in turn promotes metabolic disorders.
Study of the Intrinsic Factors Determining the Near-Threshold Fatigue Crack Propagation Behavior of a High-Strength Titanium Alloy
Authors: Wang Huan , Zhao Yongqing , Guo Ping , Qiang Fei , Zhang Lei , Qiao Zhongli , Xin Shewei
Published: January 2025

The resistance to near-threshold fatigue crack growth and its correlation with the microstructure of the Ti-5Al-3Mo-3V-2Zr-2Cr-1Nb-1Fe alloy were investigated. K-decreasing fatigue crack propagation rate tests were conducted on compact tension samples (ASTM standard) with a stress ratio R of 0.1 and a frequency of 15 HZ in a laboratory atmosphere. At a similar strength level of 1200 MPa, the sample with a fine basket-weave microstructure (F-BW) displayed the slowest near-threshold fatigue crack propagation rate compared with the samples with equiaxed (EM) and basket-weave (BW) microstructures. The fatigue threshold value (ΔKth) was 4.4 MPa·m1/2 for F-BW, 3.6 for BW, and 3.2 for EM. The fracture surfaces and crack profiles were observed by scanning electron microscopy (SEM) and electron backscatter diffraction (EBSD) to elucidate the mechanism of fatigue crack propagation in the near-threshold regime. The results revealed that the near-threshold crack growth in the three samples was primarily transgranular. The crack always propagated parallel to the crystal plane, with a high Schmid factor. In addition, the near-threshold fatigue crack growth behavior was synergistically affected by the crack tip plastic zone and crack bifurcation. The increased fatigue crack propagation resistance in F-BW was attributed to the better stress/strain compatibility and greater number of interface obstacles in the crack tip plastic zone.
Effect of Trace Rare Earth Elements (Ce) on the Corrosion Resistance of High-Strength Weathering Bridge Steels
Authors: Chen Jiquan , Dong Ruifeng , Lei Yuansu , Zhou Peiying , Yang Xiong , Fan Lifeng
Published: January 2025

In this study, Q370qENH high-strength weathering bridge steel was used as the base material. The corrosion experiment in a marine atmosphere was simulated by the salt spray test, and the outdoor atmospheric exposure corrosion experiment and electrochemical method test were carried out. The corrosion behavior of Q370qENH high-strength weathering bridge steel in a marine atmosphere was studied using electron probe microanalysis (EPMA), field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), and other surface testing techniques. The results show that the corrosion rate of the steel gradually decreases with the increase in the content of trace rare earth elements. Ce played a role in the modification of inclusions so that MnS was modified into rare earth composite inclusions, which slowed down the occurrence of corrosion. The enrichment of Cu alloy elements in the inner rust layer of the rare earth experimental steel improves the compactness of the rust layer, and the thickness of the inner rust layer is increased by 42%, which enhances the stability of the rust layer. With the increase in cerium, the protection coefficient α/γ* of the rust layer of experimental steel increases, indicating that the corrosion resistance of the material is improved. In addition, the electrochemical results show that the addition of rare earth elements in Q370qENH steel will lead to a positive shift in the electrochemical self-corrosion potential, a larger impedance radius of the steel rust layer, and a stronger protective effect. Due to the addition of trace cerium, the seawater corrosion resistance of the test steel is improved.
Effect of Roundness and Surface Roughness of Foundry Sand on the Temperature Change of Sand Cores for Aluminum Casting
Authors: Ha Taekyu , Kim Jongmin , Lee Youngki , Kang Byungil , Kim Youngjig
Published: January 2025

Organic binder in sand cores, such as phenol-formaldehyde binder, rapidly decomposes above 550 K, releasing gases including volatile organic compounds (VOCs) and hydrocarbon gases. A rapid temperature rise in the core increases gas evolution during the casting process. The roundness and surface roughness of foundry sand particles influence temperature changes in sand cores. This study investigates how these factors affect temperature change in packed sand beds and cores and the gas porosity at the interface between the core and the A356 Al castings. Temperature changes were measured using three types of sand: angular artificial sand (AAS), natural sand (NS) with different roundness and surface roughness, and polished AAS with a smooth surface. Additionally, the temperature rise in cores was measured with varying proportions of AAS. Packed sand beds and cores with low roundness and rough surface morphology form macro and micro-gaps due to high porosity and surface roughness. These gaps, filled with interstitial gas of low thermal conductivity, hinder heat conduction. Delaying the temperature rise of the core could reduce weight loss from binder decomposition, thereby decreasing gas porosity at the interface between the A356 Al castings and the core. These findings on the effects of roundness and surface roughness on temperature changes in packed sand beds and cores provide methods for reducing gas emission during the casting process.
Investigation of the Heat Treatment Regimes on the Structure and Microhardness of Laser Direct Energy Deposition Aluminum Alloy AlSi10Mg
Authors: Volosevich Darya , Shabunina Zhanna , Yurchenko Nikita , Mendagaliev Ruslan , Slatenko Edem , Klimov Georgii , Klimova-Korsmik Olga , Eremeev Aleksey
Published: January 2025

This study investigates the influence of various heat treatment regimes on the structure and microhardness of the aluminum alloy AlSi10Mg processed by the L-DED method. The study considers heat treatment regimes for solid solution in the temperature range of 500−540 °C with holding times of 30–120 min, as well as artificial aging regimes in the temperature range of 160−190 °C with holding times of 4–8 h. As a result of studying the structure and mechanical properties of the heat-treated samples, it became clear that the optimal regime can be considered the regime of 500 °C for 30 min followed by 190 °C for 6 h. This regime leads to the formation of a uniform structure with the breakage of the eutectic network into separate spherical silicon inclusions. The microhardness in this case is 90 HV, which is 55% higher than the initial state. Using TEM, it was established that the reason for the increase in hardness is the formation of nanoscale inclusions β″ (Mg5Si6).
Shortwave Infrared Spectroscopy and Geochemical Characteristics of White Mica-Group Minerals in the Sinongduo Low-Sulfide Epithermal Deposit, Tibet, China
Authors: Li Xuerui , Guo Na , Li Chunhao , Deng Siyuan , Zhou Weirui
Published: January 2025

Sinongduo is the first low-sulfidation epithermal deposit to be found in the Gangdese metallogenic belt, Xizang, China. Through the integration of Shortwave Infrared (SWIR) spectroscopy, an electron probe microanalysis (EPMA), X-ray diffraction (XRD), and three-dimensional modeling, the following findings were obtained: (1) The alteration minerals in the belt predominantly belong to the white mica group, with mineral assemblages of muscovite → muscovite + illite → muscovite + illite + montmorillonite → muscovite + paragonite + montmorillonite → muscovite + paragonite + illite + montmorillonite from the outer edges to the ore zones. (2) On the basis of the number of interlayer cations, the white mica-group minerals were classified into three distinct types. (3) The SWIR spectral exploration model indicates the spatial distribution of the mineral combinations and their spectral characteristics in the low-sulfidation epithermal deposit. On the basis of these results, we predict that Woruo, an area located north of Sinongduo, has immense potential for future mineral exploration.
Biopesticide Compounds from an Endolichenic Fungus Xylaria sp. Isolated from the Lichen Hypogymnia tubulosa
Authors: Lyssaios Fotios A. , González-Coloma Azucena , Andrés María Fe , Díaz Carmen E.
Published: January 2025

Endolichenic fungi represent an important ecological group of microorganisms that form associations with photobionts in the lichen thallus. These endofungi that live in and coevolve with lichens are known for synthesizing secondary metabolites with novel structures and diverse chemical skeletons making them an unexplored microbial community of great interest. As part of our search for new phytoprotectants, in this work, we studied the endolichenic fungus Xylaria sp. isolated from the lichen Hypogymnia tubulosa, which grows as an epiphyte on the bark of the endemic Canarian tree Pinus canariensis. From the extract of the liquid fermentation, we isolated two unreported piliformic derivatives, (+)-9-hydroxypiliformic acid (1) and (+)-8-hydroxypiliformic acid (2), along with four previously reported compounds, (+)-piliformic acid (3), hexylaconitic acid A anhydride (4), 2-hydroxyphenylacetic acid (5), and 4-hydroxyphenylacetic acid (6). Their structures were elucidated based on NMR and HRESIMS data. The extract and the isolated compounds were tested for their insect antifeedant (Myzus persicae, Rhopalosiphum padi, and Spodoptera littoralis), antifungal (Alternaria alternata, Botrytis cinerea, and Fusarium oxysporum), nematicidal (Meloidogyne javanica), and phytotoxic effects on mono- and dicotyledonous plant models (Lolium perenne and Lactuca sativa). Compounds 4, 5, and 6 were effective antifeedants against M. persicae and 4 was also active against R. padi. Moreover, 3 and 4 showed antifungal activity against B. cinerea and 4 was the only nematicidal. The extract had a strong phytotoxic effect on L. sativa and L. perenne growth, with compounds 3, 4, and 5 identified as the phytotoxic agents, while at low concentrations compounds 3 and 4 stimulated L. sativa root growth.
Imidazolium-Functionalized Ionic Porous Organic Polymer for Efficient Removal of Oxo-Anions Pollutants from Water
Authors: Huang Wei , Zhong Hong , Lin Junyue , Li Xiaodan , Mao Jie , Dai Hongliang , Li Yuntong , Xiang Shengchang
Published: January 2025

The development of highly efficacious materials for the removal of toxic heavy metal-based oxo-anions is of utmost importance. Herein, an ionic porous organic polymer (designated as HB-IPOP) was synthesized through a quaternization reaction between hexa(imidazole-1-yl)benzene and 5,5′-Bis(bromomethyl)-2,2′-bipyridine. HB-IPOP exhibited high saturation uptake capacities, specifically 292 mg·g−1 for Cr2O72− and 531 mg·g−1 for ReO4−, and demonstrated exceptional selectivity for both Cr2O72− and ReO4−. Additionally, HB-IPOP demonstrates high recyclability, allowing its reuse over at least five cycles. DFT calculations confirmed that the superior interaction sites and binding energies of HB-IPOP with Cr2O72− and ReO4− outperform the affinities of other competing anions. This theoretical validation aligns with the experimentally observed high capacity and selectivity of HB-IPOP for these oxo-anions. Hence, HB-IPOP emerges as a promising candidate to replace current adsorbent materials in the effective removal of Cr2O72− and TcO4− anions from water.
A Density Functional Valence Bond Study on the Excited States
Authors: Wu Xun , Zheng Peikun , Chen Tingzhen , Zhou Chen , Su Peifeng , Wu Wei
Published: January 2025

The accurate description of excited states is crucial for the development of electronic structure theory. In addition to determining excitation energies, strong state interactions arise when electronic states with the same symmetry are degenerate or nearly degenerate, often requiring a multi-state treatment. These strong correlation effects and state interactions can be effectively handled by the Hamiltonian matrix correction-based density functional valence bond (hc-DFVB) method, a multi-reference density functional theory capable of accurately describing electronic state interactions. In this paper, we explore the low-lying excited states of four isoelectronic systems (C2H, CN, CO+, BO) using valence bond methods, including the valence bond self-consistent field (VBSCF) and hc-DFVB methods. Our results show that the hc-DFVB method provides significantly better excitation energies compared to VBSCF. Furthermore, hc-DFVB can reliably predict the correct ordering of excited states, whereas VBSCF shows some ordering inconsistencies. By categorizing the VB structures into groups based on point group symmetry, we can extract the key structural contributions and bonding pictures of each state from the weight distribution of these groups. Additionally, we study the potential energy curves for lithium fluoride (LiF) and a mixed-valence spiro cation, demonstrating the superior performance of hc-DFVB when applied to the study of near-degenerate excited states in the avoided crossing region.
Improved Selectivity of CeMnOx/Pt@SnO2 Laminated MOS Sensor for Hydrogen Cyanide Under Temperature Dynamic Modulation
Authors: Liu Yadong , Qi Yelin , Yang Wen , Ma Tengbo , Zhang Shunping , Liang Ting
Published: January 2025

Poor selectivity is one of the main bottlenecks restricting the development of metal oxide semiconductor (MOS) sensors. In this paper, using hydrogen cyanide (HCN) as the target gas, CeMnOx as the catalytic layer material and Pt@SnO2 as the gas-sensitive layer material, we have proposed a scheme to improve the selectivity of a catalytic layer/gas-sensitive layer-laminated MOS sensor under dynamic temperature modulation. We tested HCN and 12 kinds of battlefield environment simulation gases, and the results showed that the CeMnOx/Pt@SnO2 sensor, under the condition of temperature dynamic modulation (a constant temperature of 400 °C for the gas-sensitive layer and a variable temperature of room temperature to 400 °C for the catalytic layer; the heating and cooling rates were 200 °C/s, the highest temperature was maintained for 2 s, and the lowest temperature was maintained for 2 s), distinct characteristic peaks appeared on the G-T curves of the resistance response to HCN only. The quantification of the characteristic peaks was performed by peak heights, and the peak height of 5 mg/m3 HCN was obtained up to 0.104, while the peak heights of the other gases at the same concentration were up to 0.034. The peak height of HCN was significantly higher than that of other gases, which verified the high selectivity of the sensor for HCN. Meanwhile, the sensor also showed good sensitivity, response/recovery time, stability and anti-interference for HCN under the above temperature dynamic modulation. This work provides an important reference for the selectivity improvement of MOS sensors for HCN.
Improving Electrochemical Performance of Ultrahigh-Loading Cathodes via the Addition of Multi-Walled Carbon Nanotubes
Authors: Choi Chan Ju , Kim Tae Heon , Kim Hyun Woo , Jeon Do Man , Han Jinhyup
Published: January 2025

Achieving high energy densities in lithium-ion batteries requires advancements in electrode materials and design. This study investigated the incorporation of multi-walled carbon nanotubes (MWCNTs) with high commercial viability as conductive additives into two types of high-nickel cathode materials, LiNi0.8Co0.1Mn0.1O2 and LiNi0.92Co0.07Mn0.01O2. To ensure a uniform distribution within the electrodes, MWCNTs were uniformly dispersed in the solvent using ultrasonication, the most effective and straightforward dispersion method. This enhancement improved both electronic and ionic conductivity, facilitating the formation of an efficient electron transfer network. Unlike the cells using only carbon black, the electrodes with MWCNTs exhibited lower internal resistances, facilitating higher lithium-ion diffusion. The cells with MWCNTs exhibited a capacity retention of 89.5% over their cycle life, and the cells with 2 wt% MWCNTs exhibited a superior rate capability at a high current density of 1 C. This study highlights that incorporating well-dispersed MWCNTs effectively enhances the electrochemical performance of ultrahigh-loading cathodes in lithium-ion batteries (LIBs), providing valuable insights into electrode design.
Perceptions and Utilization of Registered Dietitian Nutritionists in Multiple Sclerosis Care: A Pilot Survey of Multidisciplinary Providers
Authors: Wills Olivia , Bradford Alaina , Bostick Mona , Probst Yasmine , Titcomb Tyler J.
Published: January 2025

Background/Objectives: Registered dietitian nutritionists (RDNs) are allied healthcare professionals who can help people with multiple sclerosis (MS) incorporate healthy eating, but little is known about their involvement in MS care. Thus, the objective of this survey was to investigate the perceptions and utilization of RDNs in MS care among multidisciplinary MS providers in the United States and Canada. Methods: An online survey was disseminated via the Consortium of MS Centers email listserv and MS-specific scientific conferences. The survey queried practitioner type, RDN referrals, the perceived benefits of RDNs in MS care, and the proportion of their patients who follow ‘MS diets’ or have nutrition-related issues. Reasons for or against RDN referral and beneficial resources were also queried. Results: Of the 60 completed surveys, respondents were primarily neurologists (n = 27, 45.0%). Most (n = 43, 71.7%) indicated that half or more of their patients inquire about diet, but n = 32 (53.3%) indicated that very few follow an ‘MS diet’ and n = 47 (78.3%) indicated that very few decline disease-modifying therapies to follow an ‘MS diet’. Most (n = 45, 77.6%) respondents indicated referring their patients to a RDN with lack of nutrition knowledge/general healthy eating advice (n = 34, 73.9%) and overweight/obesity (n = 31, 67.4%) as being the most common reasons for referral. RDNs were reported as being helpful or extremely helpful by n = 38 (84.4%) of respondents who reported referring to RDNs. Most (n = 46, 79.3%) indicated that their patients would benefit from having an RDN with MS-specialized training as a member of staff. Conclusions: MS care providers support the need for RDNs with specialized training in MS care.
Illuminating the Connection: Cutaneous Vitamin D3 Synthesis and Its Role in Skin Cancer Prevention
Authors: Uçar Nazlı , Holick Michael F.
Published: January 2025

Sunlight exposure plays an important role in human health, impacting processes such as mood, blood pressure regulation, and vitamin D3 production. Solar ultraviolet B radiation initiates vitamin D3 synthesis in the skin, which is subsequently metabolized into its biologically active form. UVB exposure plays a key role in enabling vitamin D3 synthesis, but it can also contribute to skin carcinogenesis, creating a complex interplay between its beneficial and harmful effects. Vitamin D deficiency, affecting over half the global population, is linked to a range of chronic diseases, including cancers, cardiovascular conditions, and autoimmune disorders. Simultaneously, excessive solar UVB exposure increases the risk of non-melanoma and melanoma skin cancers through mechanisms involving DNA damage and oxidative stress. This review examines the dual role of UVB radiation in health and disease, focusing on the mechanisms of cutaneous vitamin D3 synthesis, the epidemiology of skin cancer, and the protective roles of vitamin D3’s photoproducts and its active metabolite, 1,25-dihydroxyvitamin D3. Understanding these interconnections is critical for developing strategies that balance adequate sun-induced vitamin D3 production with skin cancer prevention.
The Impact of Maternal Chronic Inflammatory Conditions on Breast Milk Composition: Possible Influence on Offspring Metabolic Programming
Authors: Arenas Gabriela , Barrera María José , Contreras-Duarte Susana
Published: January 2025

Breastfeeding is the best way to provide newborns with crucial nutrients and produce a unique bond between mother and child. Breast milk is rich in nutritious and non-nutritive bioactive components, such as immune cells, cytokines, chemokines, immunoglobulins, hormones, fatty acids, and other constituents. Maternal effects during gestation and lactation can alter these components, influencing offspring outcomes. Chronic inflammatory maternal conditions, such as obesity, diabetes, and hypertension, impact breast milk composition. Breast milk from obese mothers exhibits changes in fat content, cytokine levels, and hormonal concentrations, potentially affecting infant growth and health. Similarly, diabetes alters the composition of breast milk, impacting immune factors and metabolic markers. Other pro-inflammatory conditions, such as dyslipidemia and metabolic syndrome, have been barely studied. Thus, maternal obesity, diabetes, and altered tension parameters have been described as modifying the composition of breast milk in its macronutrients and other important biomolecules, likely affecting the offspring’s weight. This review emphasizes the impact of chronic inflammatory conditions on breast milk composition and its potential implications for offspring development through the revision of full-access original articles.
Use of Ozone for Disinfection of PHARMODUCT® Automatic System for Antineoplastic Compounding
Authors: Lovino Vito , Riglietti Antonio , Tolomeo Anna , Capasso Giuseppe , Di Vittorio Miriana , Brattoli Stefano , Tesse Giuseppe , Dimiccoli Vincenzo , Spartà Marco , Perioli Luana
Published: January 2025

Background: The purpose of this work was to demonstrate the ozone efficacy for disinfection of the PHARMODUCT® automatic dispensing system for antineoplastic preparation, as a guarantee of a higher grade of cleanliness. While the use of ozone gas disinfection is almost consolidated in food and water treatment, there is a lack of scientific data in the pharmaceutical field. The scope of this study was to demonstrate the ozone efficacy for disinfection of the PHARMODUCT® automatic dispensing system, before starting the antineoplastic preparation, in order to ensure a high degree of cleanliness and, at the same time, to define a biodecontamination procedure that could also be translatable to other automated compounding systems on the market. Methods: Ozone efficacy was determined by calculating the difference (pre-exposure–post-exposure) in CFU counts on the plate. A group of four different ATCC-selected microbial strains were tested using two distinct cycles. The first one was evaluated with an ozone gas concentration of 40 ppm for 40 min; the second cycle increased the concentration to 60 ppm for the same duration. Results: Results showed that exposure to 40 ppm ozone gas led to a 4-log reduction of all tested ATCC strains. In contrast, exposure to 60 ppm ensured a 6-log reduction. Conclusions: The ozone disinfection process, applied to the PHARMODUCT® system, provides a superior grade of cleanliness compared to the manual disinfection procedure, thus offering insight beyond the current anti-inflammatory and analgesic application of ozone therapy in the medical field.
Laser Radar System Based on Lightweight Diffractive Lens Receiver System
Authors: Yin Jiajia , Hou Mengxia , Fan Bin , Bian Jiang , Du Junfeng
Published: January 2025

Diffractive lens has advantages over traditional reflective lens, such as light weight, high folding compression ratio, high tolerance for surface figure error and low manufacturing costs. It provides a new technical approach for a lightweight LiDAR ranging system. In this work, a laser radar system based on a diffractive lens receiver system has been designed. The receiver system is a hybrid structure consisting of an eight-level diffractive lens, a collimation set and a convergence set. Combined with the single photodetector, the designed laser radar system can simultaneously achieve measurements at near-field distances of 6.0 m, 9.9 m, and 16.1 m and far-field distances of 851.2 m.
Content Analysis of Digital Archives Contributes to the Historical Distribution and Folk Knowledge of the Highly Toxic Cicuta virosa L. in Hungary
Authors: Kis Szabolcs , Molnár V. Attila
Published: January 2025

The northern water hemlock is an endangered species that has been severely diminished in Hungary due to water regulation and river control in the 18th and 19th centuries. We collected data on this highly toxic plant from Hungary using archival sources, including digitized databases of daily and weekly newspapers and books. By exploring historical digital archives, we identified 88 locatable occurrence records spanning 65 flora mapping grids, 52 of which represent new additions to its known distribution. Between 1721 and 1943, a total of 103 records were found relating to its vernacular names. The most widespread names were csomorika (predominantly used in the Berettyó-Sárrét and Hortobágy regions), mételytorzsa (Rétköz, Taktaköz, Ecsedi-láp), and Kónyi gyökér (Fertő-Hanság region). Human poisonings caused by this species were primarily due to confusion with parsley, celery, and, less frequently, parsnips or carrots, occasionally resulting in the deaths of entire families. Children, in particular, were at risk when they accidentally consumed it raw as a snack. There have also been instances of intentional homicidal use and unintentional fatalities associated with its ethnomedicinal application. The plant was primarily used to treat scrofula (a form of tuberculosis-induced lymphoma) and for abortion.
Determination of Compressive Stress Limits for Tightened Plastic Components up to 3 mm in Bolted Joints Applicable in the Automotive Industry
Authors: Murčinková Zuzana , Holíček Rudolf , Baron Petr , Onufer Martin
Published: January 2025

This paper addresses the analysis of compressive stress limit values of plastic components with a thickness of no more than 3 mm used in bolted joints, especially in the automotive industry. The results of the compression tests show that the compressive stress limit values often exceed the tensile stress limit values specified in the material data sheets, which has a significant impact on the way in which reliable bolted joints are designed without the risk of plastic deformation. In addition to compression tests, stress tests involving axial force and torque (combined load typical for bolted joints) were also performed. Th results of both types of tests were compared in the final table, involving a comparison of yield strength under compression and yield strength under a combined load with yield strength and/or stress at break from material data sheets, estimated using tensile stress tests. Various plastic materials were tested, including Acrylonitrile Butadiene Styrene (ABS), Polyamide (PA), Polyoxymethylene (POM), Polypropylen (PP) and the glass fiber-reinforced materials. The tests showed that it is possible to exceed the tensile stress limit in material data sheets by 5 to 10% without plastic deformation and by approximately 50%, in some cases by 280%, when loading by pure compression. Considering the combined load, the compressive stress limit values are within the range of 95 to 224% of tensile stress limits. The results of the study contribute to the optimization of the plastic tightened components design and reduce the need for excessive testing in automotive production.
Off-Site Emergency Response Plans at Chemical Accidents in South Korea
Authors: Nam Minseo , Choi Youngjoo , Kim Chongmin , Yoo Byungtae
Published: January 2025

The Chemical Substances Control Act emphasizes the importance of proactive planning for chemical accident prevention and response, requiring facilities handling hazardous chemicals to develop and submit comprehensive plans in compliance with regulatory standards. Among these measures, the designation of chemical accident evacuation sites is considered a critical step to protect local residents and mitigate the impact of accidents. Despite the significance of evacuation site planning, existing research has primarily focused on the general conditions and locations of evacuation sites, with limited attention to their selection process and safety evaluation. This study aims to bridge this gap by evaluating the suitability of evacuation site locations through detailed risk assessments. Using tools such as KORA and ALOHA, the study analyzes the impact range under seasonal meteorological conditions. The limitations of current evacuation sites were assessed, and additional sites were proposed, considering the number of evacuees able to travel on foot during emergencies. The study highlights the importance of selecting evacuation sites based on seasonal weather conditions and provides actionable recommendations to improve public safety and minimize risks during chemical accidents. The findings of this study are expected to contribute to the advancement of emergency response systems, promoting a safer and more resilient environment for both local communities and industrial facilities.
What Was the “Devil’s” Body Size? Reflections on the Body Mass and Stature of the Foresta Hominin Trackmakers (Roccamonfina Volcano, Italy)
Authors: Palombo Maria Rita , Panarello Adolfo
Published: January 2025

The challenging task of correctly estimating the body size of prehistoric hominins from footprint dimensions has been a matter of long debate, but researchers are still divided about the best methodological approach for obtaining compelling estimates. This research attempts to infer the body size of the trackmakers, who impressed their footprints on the uneven ground slope of a Roccamonfina volcano’s ignimbrite (≈350 ka) at the Foresta/“Devil’s Trails” ichnosite. We used the equations selected among the most adequate for the footprints of this peculiar ichnosite with an exploratory purpose and from a critical estimation point of view. The values of the body size derived from the different equations are highly variable; the minimum and maximum values can differ by up to 50%. The variation range is similarly large when applying the same equations to the footprints from some North African and European Lower Paleolithic ichnosites. The variability of the results mainly depends on the technique of footprint measurements, the environmental context (substrate, surface slope, trackmaker gait, etc.), the equation used, and, to a minor extent, the dimensional slight differences between a fleshy foot and a footprint. This makes comparisons among the sites challenging. All things considered, we could say that the average body mass (about 60 kg) and stature (about 166 cm) of Foresta trackmakers, who may be individuals of different sexes, fall in the range of the Middle Pleistocene Homo heidelbergensis s.l.
Jewish Law-Observance in Paul
Authors: Sloan Paul T.
Published: January 2025

Several statements in Paul’s letters have led scholars to conclude that Paul was not Law-observant and that he was at best indifferent, if not antagonistic, to Jewish Law-observance. This article challenges these views by situating supposedly “negative” statements on the Law within Paul’s discourse on justification (Gal 2) and freedom from the Law of sin and death (Rom 7), and argues that aspects of 1 Cor 7, Gal 2–3, and Rom 3–4 imply Paul expected even believing Jews to remain Law-observant.
Navigating Civic Agency and Civic Space Amid Authoritarian Realities in Myanmar: Dietrich Bonhoeffer’s Concept of Divine Mandate as Public Theology
Authors: Kung Lap Yan
Published: January 2025

In recent years, civic space has been deteriorating in many countries in Southeast Asia, and there is an urgent need for a more proactive and mindful civic agency to foster a humane society. Drawing inspiration from Dietrich Bonhoeffer’s concept of divine mandate, this paper proposes a public theology within an authoritarian regime, namely Myanmar. It explores divine mandates as essential for protecting civic space, advocates for Christian discipleship as a means of civic agency, and sparks moments of possibility by recognizing the hidden God in times of suffering. This paper highlights that an ethic of responsibility towards others lies at the core of divine mandate. It encompasses being an agent of direction, memory, linguistic self-consciousness and transformation.