bluuebunny/crossref_metadata_2025 huggingface dataset:
MiRNA-30d and miR-770-5p as potential clinical risk predictors of Vasoplegic Syndrome in Patients undergoing on-pump coronary artery bypass grafting
Authors: Vilca Mejia Omar Asdrúbal , de Souza Renato Cesar , S. Santos Aritania , Meneghini Bianca , Carvalho Silva Ana Carolina , Visconde Brasil Guilherme , Oliveira Carvalho Rigaud Vagner , Palma Dallan Luís Roberto , Pinho Moreira Luiz Felipe , Ferreira Lisboa Luiz Augusto , Oliveira Dallan Luís Alberto , Kalil Jorge , Cunha-Neto Edecio , Rodrigues Pinto Ferreira Ludmila , Biscegli Jatene Fábio
Published: February 2023

The aims of this study were to perform pre-surgery miRNA profiling of patients who develop Vasoplegic syndrome (VS) after coronary artery bypass grafting (CABG) and identify those miRNAs that could be used as VS prognostic tools and biomarkers. The levels of 754 microRNAs (miRNAs) were measured in whole blood samples from a cohort of patients collected right before the coronary artery bypass grafting (CABG) surgery. We compared the miRNA levels of those who developed VS (VASO group) with those who did not (NONVASO group) after surgery. Six miRNAs (hsa-miR-548c-3p, -199b-5p, -383-5p -571 -183-3p, -30d-5p) were increased and two (hsa-1236-3p, and hsa-miR770-5p) were decreased in blood of VASO compared to NONVASO groups. Receiver Operating Characteristic (ROC) curve analysis revealed that a combination of the miRNAs, hsa-miR-30d-5p and hsa-miR-770-5p can be used as VS predictors (AUC = 0.9615, p < 0.0001). The computational and functional analyses were performed to gain insights into the potential role of these dysregulated miRNAs in VS and have identified the “Apelin Liver Signaling Pathway” as the canonical pathway containing the most target genes regulated by these miRNAs. The expression of the combined miRNAs hsa-miR-30d and hsa-miR-770-5p allowed the ability to distinguish between patients who could and could not develop VS, representing a potential predictive biomarker of VS.
Tumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer
Authors: Kitakaze Masatoshi , Fujino Shiki , Miyoshi Norikatsu , Sekido Yuki , Hata Tsuyoshi , Ogino Takayuki , Takahashi Hidekazu , Uemura Mamoru , Mizushima Tsunekazu , Doki Yuichiro , Eguchi Hidetoshi
Published: February 2023

Approximately 10% of patients with colorectal cancer with submucosal invasion have lymph node metastasis. Pathological risk factors for lymph node metastasis have varying sensitivities and specificities. To predict the risk of lymph node metastasis, the identification of new risk factors is vital. Tumor-infiltrating T cells have been reported to improve the prognosis of many solid tumors. Therefore, the purpose of this study was to examine the relationship between lymph node metastasis and tumor-infiltrating T cells in patients with colorectal cancer with submucosal invasion. We examined CD8+ tumor-infiltrating T cells level as a risk factor for lymph node metastasis in patients with colorectal cancer with submucosal invasion. Using immunohistochemical staining, we identified CD8 + T cells in surgically resected specimens from 98 patients with SM-CRC. We showed that low CD8+ tumor-infiltrating T cells levels are positively correlated with lymph node metastasis. Furthermore, by combining the number of CD8+ tumor-infiltrating T cell and the number of CD103+ tumor-infiltrating T cells, the results showed a high positive predictive value for lymph node metastasis in cases with low numbers of both types of tumor-infiltrating T cells and a high negative predictive value in cases with high numbers of both types of tumor-infiltrating T cells.
Composition and taste of beef, pork, and duck meat and bioregulatory functions of imidazole dipeptides in meat
Authors: Kajiya Katsuko , Arino Madoka , Koshio Akari , Minami Yuji
Published: February 2023

This study quantified the nutritional components and imidazole dipeptide levels of commercially available meats (beef, pork, and duck), and their effects on taste were quantified via taste recognition devices. Although meat and its products are considered high-risk diets, meat components, such as imidazole dipeptides, exert bioregulatory functions. Further, considering their bioregulatory function, commercial meats’ antioxidant activity and vascular endothelial function were examined. Characteristic variations in nutritional components were observed depending on the type and part of meat analyzed. These components affected the taste and texture of meat. The main imidazole dipeptides detected were anserine (duck meat) and carnosine (beef and pork). Meat with larger quantities of total imidazole dipeptide demonstrated better sensory test results. Therefore, anserine and carnosine effects on taste were determined using a taste recognition device; carnosine alone produced a noticeably bitter taste, whereas adding anserine reduced bitterness and enhanced umami taste. In a few cases, cooking enhanced the quantity of carnosine and/or anserine and their antioxidant activities. We demonstrated the ability of imidazole dipeptides, particularly anserine, to improve nitric oxide production in vascular endothelial cells. This study provides essential information for health-conscious consumers to develop high-quality, functional meat products.
Calibration of spectra in presence of non-stationary background using unsupervised physics-informed deep learning
Authors: Puleio Alessandro , Rossi Riccardo , Gaudio Pasqualino
Published: February 2023

Calibration is a key part of the development of a diagnostic. Standard approaches require the setting up of dedicated experiments under controlled conditions in order to find the calibration function that allows one to evaluate the desired information from the raw measurements. Sometimes, such controlled experiments are not possible to perform, and alternative approaches are required. Most of them aim at extracting information by looking at the theoretical expectations, requiring a lot of dedicated work and usually involving that the outputs are extremely dependent on some external factors, such as the scientist experience. This work presents a possible methodology to calibrate data or, more generally, to extract the information from the raw measurements by using a new unsupervised physics-informed deep learning methodology. The algorithm allows to automatically process the data and evaluate the searched information without the need for a supervised training by looking at the theoretical expectations. The method is examined in synthetic cases with increasing difficulties to test its potentialities, and it has been found that such an approach can also be used in very complex behaviours, where human-drive results may have huge uncertainties. Moreover, also an experimental test has been performed to validate its capabilities, but also highlight the limits of this method, which, of course, requires particular attention and a good knowledge of the analysed phenomena. The results are extremely interesting, and this methodology is believed to be applied to several cases where classic calibration and supervised approaches are not accessible.
ADAR1 is a promising risk stratification biomarker of remnant liver recurrence after hepatic metastasectomy for colorectal cancer
Authors: Hata Nanako , Shigeyasu Kunitoshi , Umeda Yuzo , Yano Shuya , Takeda Sho , Yoshida Kazuhiro , Fuji Tomokazu , Yoshida Ryuichi , Yasui Kazuya , Umeda Hibiki , Takahashi Toshiaki , Kondo Yoshitaka , Kishimoto Hiroyuki , Mori Yoshiko , Teraishi Fuminori , Yamamoto Hideki , Michiue Hiroyuki , Nakamura Keiichiro , Tazawa Hiroshi , Fujiwara Toshiyoshi
Published: February 2023

Adenosine-to-inosine RNA editing is a process mediated by adenosine deaminases that act on the RNA (ADAR) gene family. It has been discovered recently as an epigenetic modification dysregulated in human cancers. However, the clinical significance of RNA editing in patients with liver metastasis from colorectal cancer (CRC) remains unclear. The current study aimed to systematically and comprehensively investigate the significance of adenosine deaminase acting on RNA 1 (ADAR1) expression status in 83 liver metastatic tissue samples collected from 36 patients with CRC. The ADAR1 expression level was significantly elevated in liver metastatic tissue samples obtained from patients with right-sided, synchronous, or RAS mutant-type CRC. ADAR1-high liver metastasis was significantly correlated with remnant liver recurrence after hepatic metastasectomy. A high ADAR1 expression was a predictive factor of remnant liver recurrence (area under the curve = 0.72). Results showed that the ADAR1 expression level could be a clinically relevant predictive indicator of remnant liver recurrence. Patients with liver metastases who have a high ADAR1 expression requires adjuvant chemotherapy after hepatic metastasectomy.
A potential platform of combining sialic acid derivative-modified paclitaxel cationic liposomes with antibody–drug conjugates inspires robust tumor-specific immunological memory in solid tumors
Authors: Sun Wenliang , Li Yantong , Sui Dezhi , Qi Zhaowei , Zhao Xinran , Zhou Wei , Hu Huiguo , Liu Xinrong , Song Yanzhi , Deng Yihui
Published: February 2023

The combined application of SA-modified cationic liposomes with ADCs induces complete tumor regression and inspires robust tumor-specific immunological memory.
Cost-effective preparation of layered tantalum oxynitrides for visible light-driven photocatalysis
Authors: Chen Wenqian , Wang Zihan , Wang Peng , Li Jinkun , Wang Jiajun , Tang Liang
Published: February 2023

Layered oxynitrides are promising materials for visible light photocatalysis.
Graphene oxide modulated dual S-scheme ultrathin heterojunctions with iron phthalocyanine and phase-mixed bismuth molybdate as wide visible-light catalysts
Authors: Hu Donghui , Song Tao , Zada Amir , Yan Rui , Li Zhijun , Zhang Ziqing , Bian Ji , Qu Yang , Jing Liqiang
Published: February 2023

Graphene oxide modulated dual S-scheme ultrathin heterojunctions with iron phthalocyanine and phase-mixed bismuth molybdate as wide visible-light catalysts for tetracycline degradation.
Association of egg consumption with colorectal polyp prevalence: findings from the Lanxi Pre-Colorectal Cancer Cohort (LP3C) in China
Authors: Shen Jia , Li Yin , Xu Meihui , Wu Fei , Jiang Yanjie , Liu Xiaohui , Ao Yang , Lin Qianru , Zhuang Pan , Jiao Jingjing , Zheng Weifang , Zhang Yu
Published: February 2023

Higher egg consumption is correlated with a higher polyp prevalence among the Chinese population, which was ascribed to the high dietary cholesterol in eggs.
A systematic study of high resolution multielemental quantitative bioimaging of animal tissue using LA-ICP-TOFMS
Authors: Strekopytov Stanislav , Billimoria Kharmen , Goenaga-Infante Heidi
Published: February 2023

A systematic approach towards high resolution quantitative multi-element imaging of biological tissue by ICP-TOFMS.
Full-colour Jabuticaba-like nanostructures via the multiplex and orthogonal self-assembly of protein-conjugated quantum dots with engineered biofilms
Authors: Deng Zhengtao , Chen Allen Y. , Zakeri Bijan , Zhong Chao , Lu Timothy K.
Published: February 2023

Genetically engineered Escherichia coli biofilms can achieve the large-scale organization of protein-conjugated fluorescent RGB QDs into full-color Jabuticaba-like nanostructures with high complexity and specificity.
Orientation–polarization dependence of pressure-induced Raman anomalies in anisotropic 2D ReS2
Authors: Wen Ting , Zhang Maodi , Li Jing , Jiao Chenyin , Pei Shenghai , Wang Zenghui , Xia Juan
Published: February 2023

In this work, we identify the effect of pressure on different components of the full 3 × 3 Raman tensor in anisotropic ReS2via measuring and analyzing the pressure-induced Raman responses under four specific orientation–polarization configurations.
Self-assembly of Co-doped MnO2 nanorod networks with abundant oxygen vacancy-modified separators for high-performance Li–S batteries
Authors: Cai Chuyue , Wu Liping , Cai Zhiwei , Yu Fang , Zhang Liu , Wang Liya , Mei Tao , Lin Liangyou , Wang Xianbao
Published: February 2023

A novel separator of Co-doped MnO2 with abundant oxygen vacancies exhibits a high reversible capacity of 902.0 mA h g−1 at 0.5 C after 200 cycles for Li–S batteries.
Synthesis of 5H-chromeno[3,4-c]pyridine derivatives through ruthenium-catalyzed [2 + 2 + 2] cycloaddition
Authors: Parisot William , Huvelle Steve , Haddad Mansour , Lefèvre Guillaume , Phansavath Phannarath , Ratovelomanana-Vidal Virginie
Published: February 2023

Efficient access to 5H-chromeno[3,4-c]pyridines using Ru-catalyzed [2 + 2 + 2] cycloaddition of α,ω-diynes with cyanamides was developed, providing valuable tricyclic pyridine building blocks and enabling access to a biologically relevant intermediate.
Electrochemical dehydrogenative cyclization/aromatization of aniline-tethered alkylidenecyclopropanes: facile access to benzo[c]carbazoles
Authors: Huang Zhi-Jia , Qin Jin-Hao , Huang Miao-Lian , Sun Qing , Xie Hai-Yang , Li Yang , Li Jin-Heng
Published: February 2023

A novel electrochemical dehydrogenative cyclization/aromatization of aniline-tethered alkylidenecyclopropanes enabled by N–H/C–H functionalization is described.
Quantum modeling of dimethoxyl-indaceno dithiophene based acceptors for the development of semiconducting acceptors with outstanding photovoltaic potential
Authors: Rashid Ehsan Ullah , Hadia N. M. A. , Shawky Ahmed M. , Ijaz Nashra , Essid Manel , Iqbal Javed , Alatawi Naifa S. , Ans Muhammad , Khera Rasheed Ahmad
Published: February 2023

Seven new small acceptor molecules (ID1–ID7) have been computationally developed to enhance the efficiency of organic solar cells. Different photovoltaic aspects of these newly proposed molecules are estimated and compared with reference molecules.
Steering self-organisation through confinement
Authors: Araújo Nuno A. M. , Janssen Liesbeth M. C. , Barois Thomas , Boffetta Guido , Cohen Itai , Corbetta Alessandro , Dauchot Olivier , Dijkstra Marjolein , Durham William M. , Dussutour Audrey , Garnier Simon , Gelderblom Hanneke , Golestanian Ramin , Isa Lucio , Koenderink Gijsje H. , Löwen Hartmut , Metzler Ralf , Polin Marco , Royall C. Patrick , Šarić Anđela , Sengupta Anupam , Sykes Cécile , Trianni Vito , Tuval Idan , Vogel Nicolas , Yeomans Julia M. , Zuriguel Iker , Marin Alvaro , Volpe Giorgio
Published: February 2023

In this perspective article, we discuss how soft matter can spearhead efforts to harness confinement as a tool to steer self-organisation across different scales and disciplines.
The design and synthesis of new advanced energetic materials based on pyrazole–triazole backbones
Authors: Tang Jie , Xiong Hualin , Tang Yongxing , Yang Hongwei , Cheng Guangbin
Published: February 2023

This study presents an empirical method to design and synthesis of a series of pyrazole-triazole derivatives, which emerges and provides efficient guidelines for the design of new HEDMs in the future.
The coordination chemistry of 2,4,6-oxy functionalised 1,3,5-triphosphinines
Authors: Abels Anne Sofie , Eiler Frederik , Le Corre Grégoire , Jurt Pascal , Wörle Michael , Verel René , Benkő Zoltan , Grützmacher Hansjörg
Published: February 2023

A comparison of nine stable 2,4,6-oxy functionalised 1,3,5-triphosphinine complexes [M{P3C3(OX)3}(CO)3] with M = Cr(0), Mo(0), W(0) and X = H, SitBuPh2, B(ipc)2] allows to investigate the binding properties of these heterocycles with a C3P3 core in more detail.
Frequency-dependent electrical properties of microscale self-enclosed ionic liquid enhanced soft composites
Authors: Fan Yucheng , Hang Ziyan , Liu Huanxun , Feng Chuang , Yang Jie , Su Yu , Weng George J.
Published: February 2023

The incorporation of room temperature ionic liquids (ILs) into dielectric elastomer composites is currently generating great interest due to their potential applications in soft actuators and optical-related devices.
Rheology and structure of elastic capsule suspensions within rectangular channels
Authors: Millett Paul C.
Published: February 2023

The rheology of elastic capsule suspensions in planar and rectangular Poiseuille flow conditions is highly dependent on inertia, membrane deformability, and channel crosssectional dimensions.
Time‐sensitive coverage control for non‐holonomic and heterogeneous robots: An extremum seeking framework and application
Authors: Zhang Liang , Deng Jinghui , Zhou Kun , Yu Tao , Song Jun , He Shuping
Published: February 2023

This work addresses a time‐sensitive coverage control problem for multiple non‐holonomic mobile robots. The coverage objective is evaluated by the total arrivial time of robots reaching their dominant clients with the predefined constant but heterogeneous velocities. An extremum‐seeking control framework is proposed, including a numerical optimizer that iteratively produces the optimal waypoints of robots minimizing the total arriving time and a state regulator that drives the robot's positions to the optimal locations under both constraints non‐holonomic kinematic model and the constant‐velocity. An improved K‐means algorithm is first designed to produce the waypoint sequence. A theoretical analysis of the convergence of coverage objectives is provided. Then a fixed‐time state regulator for the robot's angular velocity is derived from regulating robot positions to the desired waypoints within each time step that varies with the heterogeneous traversing velocity and the distance between waypoints. Finally, the results are validated by a virtual robotic simulation platform and the experiment on real robots, showing that the proposed methods can efficiently deploy multiple heterogeneous robots for time‐sensitive services to clients with a discrete distribution. The simulation and experimental code are open‐sourced at https://gitee.com/ahu‐icip/simulation.git.
Comparison between peak values of induction motor currents’ waveforms during nearby three‐phase short‐circuits and results from standardized calculations
Authors: Sorrentino Elmer , Vera Andres
Published: February 2023

This article shows a comparison of peak values of measured and computed waveforms of induction motor currents during nearby three‐phase short circuits with the results from the standardized calculations of those currents. The methods for computing short‐circuit currents according to IEC and ANSI standards are based on phasors at grid frequency, and the correspondent transient result is approximated to a simple sine wave plus a decaying DC component. However, the measured and simulated waveforms are far away from those simple waveforms. Thus, the peak values computed by standardized methods must be obviously different than the peak values of measured and simulated waveforms. It is herein shown that these differences are larger in smaller motors, and it is also shown that standardized methods to compute these motor currents are accurate enough although they are simply based on phasors at grid frequency. On the other hand, the maximum value of the first peak of motor contribution does not necessarily occur at the same time of the maximum first peak of grid contribution. This fact had been rarely mentioned, and an analysis about its influence was not found in the literature. Herein, it is shown that the influence of this point is not very important in the analyzed cases.
A novel robust Volt/Var optimization method based on worst‐case scenarios for distribution network operation
Authors: Ahmadi Mahdi , Salami Abolfazl , Alavi Mohammadhasan
Published: February 2023

The Volt/Var optimization (VVO) problem is used for scheduling the voltage regulation and reactive power compensation equipment in distribution networks to minimize power loss and voltage violation. In order to solve the VVO problem for a forthcoming time horizon, it is necessary to predict some parameters such as load demand and renewable energy production. The prediction of these parameters is always accompanied by uncertainty that robust optimization can be used to solve this concern. This paper presents a scenario‐based robust Volt/Var optimization (RVO) method that significantly reduces the number of scenarios required for the worst‐case approach. Solving the VVO problem with the worst‐case scenarios reduces the computational burden and maintains the voltage security of the distribution network against the severe events. The proposed RVO is formulated based on a mixed‐integer second‐order cone programming (MISOCP) model in which Volt/Var control (VVC) equipment is scheduled over a two‐stage strategy. The proposed method is validated using modified 33‐bus and 69‐bus IEEE test systems. The results demonstrate that the proposed RVO method maintains the network's voltage profile within the acceptable range against uncertainties.
Modelling and simulation of (connected) autonomous vehicles longitudinal driving behavior: A state‐of‐the‐art
Authors: Sadid Hashmatullah , Antoniou Constantinos
Published: February 2023

Microscopic traffic models (MTMs) are widely used for assessing the impacts of (connected) autonomous vehicles ((C)AVs). These models utilize car‐following (CF) and lane‐changing models to replicate the (C)AVs driving behaviors. Numerous studies are being lately published regarding the approximation of the driving behaviors of (C)AVs (especially CF behavior) with many state‐of‐the‐art modelling methods. Still, there is no established CF model to mimic the accurate behavior of (C)AVs. Researchers often utilize existing mathematical CF models as well as limited data‐driven models for (C)AVs modelling. Meanwhile, several studies conduct simulation‐based impact assessments with various key performance indicators (KPIs). Identification of these KPIs is a crucial step for future studies. Hence, this paper presents a comprehensive outlook on different CF models with their adopted parameters for (C)AVs modelling and investigates how and in which aspects might the CF behaviors of (C)AVs are different from human‐driven vehicles. In addition, the recent publications in data‐driven CF models including their methodologies are explicitly discussed. This work also reviews simulation‐based studies with the reported impacts and used KPIs. Finally, in light of the findings of this paper, several future research needs are highlighted.
An improved simplified composite right‐/left‐handed zeroth‐order resonator and its application to design a compact microstrip bandpass filter with enhanced upper stopband
Authors: Yu Yongchang , Ding Mingling , Gong Jianqiang , Li Xin , Zeng Xiangui
Published: February 2023

An improved simplified composite right‐/left‐handed (SCRLH) zeroth‐order resonator (ISZOR) is introduced, comprising two lateral parallel capacitors and a centred T‐type inductor circuit. Starting from the lumped circuit of the ISZOR, its miniature microstrip layout can be generated with on more than three times full‐wave simulations by virtue of the implicit space mapping technique. Multi‐solutions of the microstrip ISZOR with identical fundamental mode are obtained by sweeping key physical and electrical parameters, uncovering the relationship among physical sizes, resonant modes, unloaded quality factors and circuit elements. A three‐pole microstrip Chebyshev bandpass filter (BPF) with ultra‐wide upper stopband is further designed. By choosing the constituent ISZORs with identical base frequency but different higher resonant frequencies and applying the over‐coupled I/O terminals, wideband spurious response suppression in the upper stopband is achieved. The target BPF centers at 3.1 GHz with a relatively bandwidth of 5%, which is optimised through a customised aggressive space mapping iterative process. The optimal BPF layout dimensions are automatically obtained with just a few time‐consuming full‐wave simulations. A prototype measurement shows the BPF features good bandpass selectivity in a simple and easy‐to‐fabricate structure, with a transversal size reduction of more than 65% compared to a former counterpart and a rejection level better than 15 dB over 40.0 GHz.
Success Factors of Digital Platform Design
Authors: Steffen Barbara , Möller Frederik , Stachon Maleen
Published: February 2023

Digital platforms disrupt today’s industries with novel offers and business models. Despite their revolutionizing impact, over 80% of platforms fail. To better understand what differentiates failing from successful platforms, we identified 30 platform success factors. These range from corporate value integration, where the platform strategy gets defined and the platform’s value definition, to the platform architecture covering all essential IT considerations and best practices making, e.g., innovation and personalization possible. To make these success factors usable in practice, we integrated all 30 success factors into the wellestablished Business Model Canvas (BMC) widely adopted for business model design. This method was chosen to test the applicability and usefulness of the platform success factors in a widely used vehicle and thus ease our workshop study. The success factors are promising, as demonstrated in our workshop study.
Ocytocine : une nouvelle cible de neuroprotection ?
Authors: Baud Olivier , Knoop Marit , Jacquens Alice , Possovre Marie-Laure
Published: February 2023

Chaque année, dans le monde, 30 millions de nouveau-nés naissent après un retard de croissance intra-utérin (RCIU) et 15 millions naissent prématurément. Ces deux conditions sont les principales causes de stress anté-/périnatal et de lésions cérébrales responsables de troubles neurocognitifs et comportementaux chez plus de 9 millions d’enfants chaque année. La plupart des stratégies pharmacologiques visant à prévenir les lésions cérébrales périnatales n’ont pas réussi à démontrer des bénéfices cliniques substantiels. En revanche, l’enrichissement de l’environnement basé sur les soins de développement, le contact peau à peau et l’exposition vocale/musicale semblent avoir des effets positifs sur la structure et la fonctionnalité du cerveau. Toutefois, les mécanismes qui sous-tendent ces effets restent inconnus. De nombreuses évidences montrent qu’un environnement défavorable pendant la grossesse et la période néonatale peut influencer les réponses hormonales du nouveau-né et avoir des conséquences neurocomportementales durables pendant la petite enfance et à l’âge adulte. L’ocytocine (OT), un neuropeptide libéré par l’hypothalamus, joue un rôle pendant la période périnatale dans l’attachement parents-enfant et dans le comportement social. En outre, des études précliniques suggèrent que l’OT est capable de réguler la réponse inflammatoire centrale aux lésions dans le cerveau adulte. Ces données font de l’OT un candidat prometteur pour la neuroprotection néonatale par la régulation de la neuro-inflammation.
De la neuroendocrinologie à la biologie cellulaire : Andrée Tixier-Vidal (1923–2021)
Authors: Calas André
Published: February 2023

Cet article relate la vie, la carrière et l’œuvre scientifique de Mme Andrée Tixier-Vidal, disparue en décembre 2021. Il montre comment, après avoir développé une approche histophysiologique originale de la neuroendocrinologie et tout particulièrement de l’axe hypophyso-thyroïdien, elle a réalisé des travaux pionniers qui ont complètement renouvelé les connaissances sur les neurones hypothalamiques à thyréolibérine (TRH) qui interviennent dans la régulation des cellules à thyréostimuline (TSH), mais également de celles à prolactine (PRL). Le fil conducteur de ses recherches a été la biologie cellulaire de la sécrétion abordée par les techniques morphologiques et cytochimiques sur des modèles originaux de cultures organotypiques d’hypophyse mais aussi de cellules tumorales GH3 et enfin de neurones hypothalamiques. Le rayonnement scientifique de Mme Tixier-Vidal et de son équipe se prolonge encore à travers les multiples générations de chercheurs qui ont eu le privilège de profiter de son dynamisme intellectuel et de son enthousiasme pour la recherche en biologie.
Response of oil producing camelina (Camelina sativa L.) crop to different agroecology and rate of NP fertilization
Authors: Sido Mekiso Yohannes , Chernet Mulatu , Ayele Wondimu , Sinore Tamirat , Tagesse Bereket
Published: February 2023

Camelina (Camelina sativa L.) is an industrial crop, which has been cultivated for centuries as an oilseed crop for human food, however, the production and its importance were not well known in Ethiopia. The current research was conducted to identify potential agroecology and rate of NP (nitrogen and phosphorous) fertilizer for the high yield production of camelina crop. Two major agroecological zones, namely highland (moist dega) and midland (moist weyna-dega) agroecologies, were tested. The experiments in both agroecology were conducted in RCBD design with similar treatments. The treatments were (T1 = 0 kg N ha−1, 0 kg P ha−1), (T2 = 30 kg N ha−1, 10 kg P ha−1), (T3 = 60 kg N ha−1, 20 kg P ha−1), (T4 = 90 kg N ha−1, 30 kg P ha−1), (T5 = 120 kg N ha−1, 40 kg P ha−1) and (T6 = 150 kg N ha−1, 50 kg P ha−1). Significant (P < 0.05) differences were observed among the fertilizer treatments. Accordingly, in highland, the highest seed weight (8.37 g plant−1) and grain yield (1814.54 kg ha−1) were recorded from T5, while in midland, the highest seed weight (3.89 g plant−1) and grain yield (843.97 kg ha−1) were recorded from T6. The highest aboveground biomass (32.08, 18.49 g plant−1) and plant height (102.34, 86.33 cm) were recorded from T6 in highland and midland agroecology, respectively. According to the Pearson’s correlation analysis, significant (P < 0.001) positive correlation was observed between the plant height, seed weight, aboveground biomass and grain yield. In general, highland agroecology showed 115%, 18.53%, 114.95% and 73.53% increase in grain yield, plant height, seed weight, and aboveground biomass, respectively as compared to midland agroecology.
Personalrecruitment in der Universitätsklinik
Authors: van den Hooven Thomas
Published: February 2023

Für die Umsetzung eines nachhaltigen Personal-Recruitments in der universitären Krankenversorgung sollten die aktuellen Entwicklungen und zugrunde liegenden Dynamiken berücksichtigt werden.
Ein besonderer Fokus wird dabei auf die Auswirkungen der Akquise von internationalen Fachkräften und den Einsatz von Beschäftigten der Arbeitnehmerüberlassung gelegt. Exemplarisch werden
verschiedene nachhaltige Strategien mit dem Schwerpunkt auf Auszubildende, Praxisanleitung und Akademisierung vorgestellt. Außerdem werden diese Einzelprojekte mit dem Magnet Recognition
Program verknüpft. Denn die deutsche Krankenhauslandschaft benötigt dringend einen grundlegenden interprofessionellen Kulturwandel, der die Weichen für eine nachhaltige Verbesserung der
Rahmenbedingungen für Pflegende in Deutschland darstellt.
Role of 68Ga-FAPI-04 PET/CT in the Initial Staging of Esophageal Cancer
Authors: Liu Huipan , Yang Xiao , You Zhouxiang , Hu Zhi , Chen Yue
Published: February 2023

Aim To investigate the clinical value of 68Ga-FAPI-04 PET/CT for initial staging of esophageal cancer.

Methods A total of 44 newly diagnosed patients with esophageal cancer were included in the analysis on the basis of postoperative pathology or clinical and radiologic follow-up.

Results All primary lesions showed increased 68Ga-FAPI-04 uptake, with an SUVmax of 14.92 ± 6.91. A total of 561 lymph nodes were verified by surgery (507) or clinical and radiologic follow-up (54), of which 92 lymph nodes were diagnosed as showing metastases. Seventy-five lymph nodes with metastases showed positive findings on 68Ga-FAPI-04, with a diameter of about 1.06 ± 0.53 cm and SUVmax of 8.10±4.71. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for lymph node metastasis detection were 81.5%, 99.3%, 96.6%, 96.2%, and 96.5%, respectively.

Conclusion 68Ga-FAPI-04 PET/CT showed good diagnostic performance in detecting lymph node metastases of esophageal cancer.
Arbeits- und Lernaufgaben zur gemeinsamen Gestaltung der Pflegeausbildung nutzen
Authors: Rohde Katrin S.
Published: February 2023

Beginnend mit dem pädiatrischen Pflichteinsatz geht es darum, die pädiatriebezogene Kompetenzentwicklung der Lernenden zu fördern 1. Hilfreich dafür sind Arbeits- und Lernaufgaben. Diese strukturieren die praktischen Einsätze orientiert an settingspezifischen Themen, sie tragen zum Transfer praktischer Erfahrungen aus anderen Einsatzbereichen bei und bringen theoretisches Vorwissen in Anwendung. Ziele und Vorgehensweisen auf dem Weg zu einer Arbeits- und Lernaufgabe werden nachfolgend beschrieben.
Exemplarische Umsetzung einer Arbeits- und Lernsituation im Kontext der Still- und Laktationsberatung
Authors: Weber Jenny
Published: February 2023

Das Pflegeberufegesetz sowie die aktualisierte Ausbildungs- und Prüfungsverordnung verlangen geplante zielführende Anleitungen durch qualifizierte Praxisanleitende an den praktischen Einsatzorten. Die Einrichtung muss die Praxisanleitungszeit im Umfang von mindestens zehn Prozent pro Einsatz der Auszubildenden in Form von gezielter Praxisanleitung nachweislich sicherstellen. Nachfolgend wird die Umsetzung am St. Joseph Krankenhaus Berlin-Tempelhof mit dem Schwerpunkt „Arbeits- und Lernaufgaben“ vorgestellt. Die Autorin ist dort die zentrale Praxisanleiterin für den Bereich der Kinder- und Jugendmedizin.
Patterns of Neck Nodal Metastasis from Oral Cavity Carcinoma
Authors: Khunteta Nitin , Makkar Ayush , Badwal Jaspreet Singh , Katta Prakhar , Choudhary Dinesh , Viswanath Mohinder , Malhotra Hemant
Published: February 2023

Objectives The aim is to study the patterns of lymph node metastasis from various sites in oral cavity cancer and determine the risk factors for metastasis.

Materials and Methods It is a prospective observational study. The inclusion criteria were—245 patients of carcinoma buccal mucosa, anterior two-thirds of tongue, hard palate, oral surface of soft palate, floor of mouth, vestibule, and alveolus. The exclusion criteria were—patients who had received preoperative chemotherapy or radiotherapy and patients with recurrent disease.

Statistical Methods All data were analyzed using SPSS 18.0 and Graphpad prism 7 software for statistical analysis. Count data have been expressed as percentages (%). The χ 2 test was used for univariate analysis of the risk factors of cervical lymph node metastasis. The odds ratio value (with 95% confidence interval) was used to express the risk of cervical lymph node metastasis. p-Value of <0.05 was considered as the difference with statistical significance.

Results The most common site involved was buccal mucosa. Patterned lymph node metastasis was seen in 93.5% cases. Skip metastasis was seen in 4.31% cases. Level I b was the most common site of nodal involvement for all primary subsites of oral cavity cancer. The incidence of positive nodes on histopathological analysis was highest in cases of lower alveolus (63.15%), followed by tongue.

Conclusion In our study, patterns of lymph node metastasis for oral cavity cancer were comparable to other studies with large number of subjects. The incidence of skip metastasis or aberrant status was low. On multivariate analysis, depth of invasion of tumor, pathologic grade, pathologic T stage, and morphologic type of growth were found to be independent predictors of risk for metastasis.
Surgical Anatomy of Temporalis Muscle Transfer with Fascia Lata Augmentation for the Reanimation of the Paralyzed Face: A Cadaveric Study
Authors: Zhang Yi , Steinbacher Johannes , Weninger Wolfgang J. , Heber Ulrike M. , Reissig Lukas , Yildiz Erdem , Tzou Chieh-Han J.
Published: February 2023

Background The temporalis muscle flap transfer with fascia lata augmentation (FLA) is a promising method for smile reconstruction after facial palsy. International literature lacks a detailed anatomical analysis of the temporalis muscle (TPM) combined with fascia lata (FL) augmentation. This study aims to describe the muscle's properties and calculate the length of FL needed to perform the temporalis muscle flap transfer with FLA.

Methods Twenty nonembalmed male (m) and female (f) hemifacial cadavers were dissected to investigate the temporalis muscle's anatomy.

Results The calculated minimum length of FL needed is 7.03cm (f) and 5.99cm (m). The length of the harvested tendon is 3.16cm/± 1.32cm (f) and 3.18/± 0.73cm (m). The length of the anterior part of the temporalis muscle (aTPM) is 4.16/± 0.80cm (f) and 5.30/± 0.85cm (m). The length of the posterior part (pTPM) is 5.24/± 1.51cm (f) and 6.62/± 1.03cm (m). The length from the most anterior to the most posterior point (aTPMpTPM) is 8.60/± 0.98cm (f) and 10.18/± 0.79cm (m). The length from the most cranial point to the distal tendon (cTPMdT) is 7.90/± 0.43cm (f) and 9.79/± 1.11cm (m).

Conclusions This study gives basic information about the temporalis muscle and its anatomy to support existing and future surgical procedures in their performance. The recommended minimum length of FL to perform a temporalis muscle transfer with FLA is 7.03cm for female and 5.99cm for male, and minimum width of 3 cm. We recommend harvesting some extra centimeters to allow adjusting afterward.
Reversible Cerebral Vasoconstriction Syndrome with Intracerebral Hemorrhage in a Thalassemic Child—An Extremely Rare Complication
Authors: Das Suman , Biswas Atanu , Roy Uma Sinha , Ray Biman Kanti
Published: February 2023

A 6-year-old known thalassemic boy presented with a posttransfusional thunderclap headache. A computed tomography scan showed left occipital lobar bleed and magnetic resonance angiography showed diffuse cerebral vasoconstriction, which resolved after 3 months, suggesting reversible cerebral vasoconstriction syndrome. He was treated with oral nimodipine for 3 months and had an excellent recovery without sequelae. To the best of the authors' knowledge, the index case is the first reported case of reversible cerebral vasoconstriction syndrome in a thalassemic child.
Harvesting wind energy to power microelectronic sensors
Authors: Thompson Avery
Published: February 2023

Aeroelastic system employs two degrees of freedom to draw power at both high and low wind speeds.
Neural network flow optimization using an oscillating cylinder
Authors: Zhang Meihua , Zheng Zhongquan Charlie , Liu Yangliu , Jiang Xiaoyu
Published: February 2023

Flow behaviors of a downstream object can be affected significantly by an upstream object in close proximity. Combined with the neural network algorithms, this concept is used for flow control in this study to optimize the aerodynamic performance of a downstream object. Flow with an oscillating cylinder placed upstream is systematically studied because there are multiple control parameters that influence the flow dynamics around the downstream object. These control parameters are used as the input factors of a back-propagation neural network, and then a revised genetic algorithm is applied to find the optimal set of control parameters. In the current study, we use an airfoil in a low-Reynolds-number flow as an example to investigate the proposed neural network flow optimization concept. The datasets used to train the neural network are from the computational simulation with a previously validated immerse-boundary method to accommodate the motion of the cylinder. The results show that by optimally placing an upstream moving cylinder, it is possible to enhance the aerodynamic performance of the downstream object. Compared to the reference case, the optimized lift/drag ratio of the downstream airfoil can be achieved 2.4 times of its reference value, while maintaining a relatively high lift coefficient.
Computational modeling and temperature measurements using emission spectroscopy on a non-transferred plasma torch
Authors: Siddanathi S. L. , Westerberg L. G. , Åkerstedt H. O. , Wiinikka H. , Sepman A.
Published: February 2023

A non-transferred plasma torch is a device used to generate a steady thermal plasma jet. Plasma torches have the potential to replace fossil fuel burners used as heat sources in the process industry. Today, however, the available plasma torches are of small scale compared to the power used in the burners in the process industry. In order to understand the effects of large scales on the plasma flow dynamics, it is essential to understand the operation of the plasma torch under different operating conditions and for different geometries. In this study, the analysis of a non-transferred plasma torch has been carried out using both computational and experimental methods. Computationally, the magnetohydrodynamic (MHD) equations are solved using a single-fluid model on a 2D axisymmetric torch geometry. The experiments are performed using emission spectroscopy to measure the plasma jet temperature at the outlet. This paper explains the changes in the arc formation, temperature, and velocity for different working gases and power inputs. Furthermore, the possibilities and disadvantages of the MHD approach, considering a local thermal equilibrium, are discussed. It was found that in general, the computational temperature obtained is supported by the experimental and equilibrium data. The computational temperatures agree by within 10% with the experimental ones at the center of the plasma torch. The paper concludes by explaining the significant impact of input properties like working gas and power input on the output properties like velocity and temperature of plasma jet.
Assessment of surface recombination in mid-wave infrared InAsSb nBn detectors using transient microwave reflectance
Authors: Arquitola A. M. , Jung H. , Lee S. , Ronningen T. J. , Krishna S.
Published: February 2023

Investigation of surface recombination is an important area for infrared detectors as the demand for smaller pixels increases. In this study, we use transient microwave reflectance to characterize the minority carrier lifetime of InAsSb nBn structures under three conditions: As-Grown, blanket Barrier-Etched, and SU-8 Passivated blanket barrier-etched. A qualitative comparison of these three samples shows that the minority carrier lifetime decreases for the Barrier-Etched sample compared to the As-Grown sample, indicating that the minority carrier lifetime is sensitive to changes in the sample surface, specifically the introduction of surface states. We compare these samples quantitatively using a polynomial fit (A−1 + Bn + Cn2). We find for the As-Grown sample A = 1.22 ± 0.45 µs, B = 2.5 ± 0.2 × 10−12 cm3/s, and C = 5.004 ± 4.996 × 10−31 cm6/s, for the Barrier-Etched sample A = 1.17 ± 0.40 µs, B = 9.9 ± 0.2 × 10−12 cm3/s, and C = 9.502 ± 9.498 × 10−30 cm6/s, and for the Passivated sample A = 1.34 ± 0.45 µs, B = 5.3 ± 0.5 × 10−12 cm3/s, and C = 5.500 ± 4.500 × 10−33 cm6/s.
Dynamic electrical compact model of GMR sensors for neuromorphically inspired applications
Authors: Reig Càndid , Cubells-Beltrán María-Dolores , Pardo Fernando , Vegara Francisco , Boluda José A. , Abrunhosa Sofia , Cardoso Susana
Published: February 2023

Neuromorphism is a state-of-the-art paradigm driving the design of many novel devices, including sensors. The development of such systems, usually involving the implementation of complex mixed CMOS/sensors chips, is constrained by the lack of compact electrical models compatible with the most utilized design tools. This paper proposes a dynamic compact electrical model specifically conceived for bio-inspired applications of giant magnetoresistance (GMR) based magnetic scanning sensors. The model includes blocks for static analysis, frequency sweeps, and transient simulations. The model, written in Verilog-A high-level language, can be directly used in most of the standard CMOS design platforms, such as Cadence.
Analysis and measurements of influences of current harmonics on the vibration responses of high-speed motors with rare-earth permanent magnets
Authors: Woo Jong-Hyeon , Lee Hoon-Ki , Kim Su-Min , Lee Jeong-In , Kim Kwan-Ho , Choi Jang-Young
Published: February 2023

This study investigates and quantifies the electromagnetic effects of vibration and noise in high-speed, permanent magnet motors. In particular, the effects of carrier harmonics generated in the electromagnetic excitation source by the pulse width modulation method are derived based on dynamic simulations. Noise, vibration, and harshness responses are then analyzed and compared to assess their induced effects on motors during actual operations.
On the magnetic and magnetocaloric properties of rare earth intermetallic compound Tb0.33Ho0.33Er0.33Ni
Authors: Mohapatra Abhaya Prasada , Arout Chelvane J. , Morozkin A. V. , Ramaprabhu S. , Nirmala R.
Published: February 2023

Polycrystalline rare earth intermetallic compound Tb0.33Ho0.33Er0.33Ni has been synthesized by arc melting under argon atmosphere. Powder X-ray diffraction data suggest that the compound Tb0.33Ho0.33Er0.33Ni crystallizes in orthorhombic structure at 300 K (FeB-type, space group Pnma). Temperature variation of magnetization reveals paramagnetic to ferromagnetic cross-over around 59 K (TC). The TC is close to the average value of the ferromagnetic transition temperatures of TbNi, HoNi and ErNi compounds. Isothermal magnetization has been measured as a function of magnetic field up to 70 kOe and the magnetocaloric effect around TC has been calculated.
Weak itinerant magnetic behaviour in Al substituted Ni
92
Cr
8 alloys
Authors: Patra Debashish , Vishvakarma Sonu , Babu P. D. , Veeturi Srinivas
Published: February 2023

In the present work we report low temperature magnetic properties of Ni92−xAlxCr8 alloys. It is found that the Curie temperature and spontaneous magnetization (MSP) get suppressed around xC ≈ 7. From the analysis of the temperature and field dependent magnetization data we have obtained high value of Rhodes–Wohlfarth ratio, which indicates the weak itinerant ferromagnetic behavior for samples below xC. This is further supported by analysing the temperature variation of MSP in the framework of spin fluctuations, SCR theory. Furthermore, the Ginzburg-Landau formalism-based on spin fluctuation theory revealed that the contribution of spin fluctuations at low temperature increases as we approach xC.
Investigation of soft magnetic material cores in transcranial magnetic stimulation coils and the effect of changing core shapes on the induced electric field in small animals
Authors: Tashli Mohannad , Weistroffer George , Mhaskar Aryan , Kumbhare Deepak , Baron Mark S. , Hadimani Ravi L.
Published: February 2023

Transcranial magnetic stimulation (TMS) is a safe, effective and non-invasive treatment for several psychiatric and neurological disorders. Lately, there has been a surge in research utilizing this novel technology in treating other neurological and psychiatric ailments. The application of TMS on several neurological disorders requires the induced electric and magnetic fields to be focused and targeted to a small region in the brain. TMS of a focal cortical territory will ensure modulation of specific brain circuitry without affecting unwanted surrounding regions. This can be achieved by altering the properties of the magnetic core material used for the TMS system. In this study, soft ferromagnetic materials having high permeability, high saturation magnetization and low coercivity have been investigated as TMS coil cores in finite element simulations. Also, magnetic field measurements have been carried out using different cores in the TMS coil. Finite element analysis of the rat head model is carried out using Sim4life software while investigating variations associated with changing the ferromagnetic core material and shape in the coil. Materials proposed for the analysis in this study include Iron Cobalt Vanadium alloy (Fe-Co-V) also known as Permendur, Carbon Steel (AISI 1010) and Manganese Zinc ferrites (MnZn ferrites). Simulation results indicated significant magnetic field distribution variation when introducing a ferromagnetic core in TMS coil, concentrating the magnetic field to the targeted region in the rat head model without stimulating adjacent regions. It was observed that the v-tip sharpened core attained the highest magnetic field and best focality among other cores in simulations and experimentally.