bluuebunny/crossref_metadata_2025 huggingface dataset:
Photobiomodulation Therapy Attenuates Anxious-Depressive-Like Behavior in the TgF344 Rat Model
Authors: Yang Luodan , Wu Chongyun , Tucker Lorelei , Dong Yan , Li Yong , Xu Peisheng , Zhang Quanguang
Published: July 2021

Background: Anxious-depressive-like behavior has been recognized as an early endophenotype in Alzheimer’s disease (AD). Recent studies support early treatment of anxious-depressive-like behavior as a potential target to alleviate memory loss and reduce the risk of developing dementia. We hypothesize that photobiomodulation (PBM) could be an effective method to alleviate depression and anxiety at the early stage of AD pathogenesis. Objective: To analyze the effect of PBM treatment on anxious-depressive-like behavior at the early stage of AD. Methods: Using a novel transgenic AD rat model, animals were divided into wild-type, AD+sham PBM, and AD+PBM groups. Two-minute daily PBM (irradiance: 25 mW/cm2 and fluence: 3 J/cm2 at the cortical level) was applied transcranially to the brain of AD animals from 2 months of age to 10 months of age. After completing PBM treatment at 10 months of age, behavioral tests were performed to measure learning, memory, and anxious-depressive-like behavior. Neuronal apoptosis, neuronal degeneration, neuronal damage, mitochondrial function, neuroinflammation, and oxidative stress were measured to test the effects of PBM on AD animals. Results: Behavioral tests showed that: 1) no spatial memory deficits were detected in TgF344 rats at 10 months of age; 2) PBM alleviated anxious-depressive-like behavior in TgF344 rats; 3) PBM attenuated neuronal damage, degeneration, and apoptosis; and 4) PBM suppresses neuroinflammation and oxidative stress. Conclusion: Our findings support our hypothesis that PBM could be an effective method to alleviate depression and anxiety during the early stage of AD development. The mechanism underlying these beneficial effects may be due to the improvement of mitochondria function and integrity and the inhibition of neuroinflammation and oxidative stress.
Latent Profile Analysis of Cognition in a Non-Demented Diverse Cohort: A Focus on Modifiable Cardiovascular and Lifestyle Factors
Authors: Lamar Melissa , Drabick Deborah , Boots Elizabeth A. , Agarwal Puja , Emrani Sheina , Delano-Wood Lisa , Bondi Mark W. , Barnes Lisa L. , Libon David J.
Published: July 2021

Background: Cognitively-defined subgroups are well-documented within neurodegeneration. Objective: We examined such profiles in diverse non-demented older adults and considered how resulting subgroups relate to modifiable factors associated with neurodegeneration. Methods: 121 non-demented (MMSE = 28.62) diverse (46%non-Latino Black, 40%non-Latino White, 15%Latino) community-dwelling adults (age = 67.7 years) completed cognitive, cardiovascular, physical activity, and diet evaluations. Latent profile analyses (LPA) employed six cognitive scores (letter fluency, letter-number sequencing, confrontational naming, ‘animal’ fluency, list-learning delayed recall, and recognition discriminability) to characterize cognitively-defined subgroups. Differences between resulting subgroups on cardiovascular (composite scores of overall health; specific health components including fasting blood levels) and lifestyle (sedentary behavior; moderate-to-vigorous physical activity; Mediterranean diet consumption) factors were examined using ANCOVAs adjusting for relevant confounders. Results: Based on sample means across cognitive scores, LPA resulted in the following cognitive subgroups: 1) high-average cognition, 55%non-Latino White and 64%female participants; 2) average cognition, 58%non-Latino Black and 68%male participants; 3) lower memory, 58%non-Latino Black participants; and 4) lower executive functioning, 70%Latinos. The high-average subgroup reported significantly higher Mediterranean diet consumption than the average subgroup (p = 0.001). The lower executive functioning group had higher fasting glucose and hemoglobin A1c than all other subgroups (p-values<0.001). Conclusion: LPA revealed two average subgroups reflecting level differences in cognition previously reported between non-Latino White and Black adults, and two lower cognition subgroups in domains similar to those documented in neurodegeneration. These subgroups, and their differences, suggest the importance of considering social determinants of health in cognitive aging and modifiable risk.
Supporting and Protecting People with Dementia in the COVID-19 Pandemic
Authors: Remoli Giulia , Canevelli Marco , Robertazzo Umberto Maria , Nuti Filippo , Bacigalupo Ilaria , Salvi Emanuela , Valletta Martina , Toccaceli Blasi Marco , Cesari Matteo , Vanacore Nicola , Bruno Giuseppe
Published: July 2021

We aimed to explore the awareness and preparedness of dementia caregivers and people with mild cognitive deficits on how to prevent COVID-19 infection and cope with the indirect consequences of the pandemic. A total of 139 patient-caregiver dyads received a telephone survey and 109 completed the survey. The majority of respondents reported having a moderate-to-good knowledge of the typical manifestations of COVID-19. Conversely, only few of them were informed of the atypical presentations and on how to recognize emergency warning signs. Filling the knowledge gaps on COVID-19 in the most vulnerable people may represent a significant resource to tackle the pandemic.
Quantitative Assessment of Cortical Excitability in Alzheimer’s Dementia and Its Association with Clinical Symptoms: A Systematic Review and Meta-Analyses
Authors: Joseph Shaylyn , Patterson Rachel , Wang Wei , Blumberger Daniel M. , Rajji Tarek K. , Kumar Sanjeev
Published: July 2021

Background: Alzheimer’s disease (AD) is characterized by cognitive and neuropsychiatric symptoms (NPS) due to underlying neurodegenerative pathology. Some studies using electroencephalography (EEG) have shown increased epileptiform and epileptic activity in AD. Objective: This review and meta-analyses aims to synthesize the existing evidence for quantitative abnormalities of cortical excitability in AD and their relationship with clinical symptoms. Methods: We systematically searched and reviewed publications that quantitatively assessed cortical excitability, using transcranial magnetic stimulation (TMS) resting motor threshold (rMT), active motor threshold (aMT), motor evoked potential (MEP) or directly from the cortex using TMS-EEG via TMS-evoked potential (TEP). We meta-analyzed studies that assessed rMT and aMT using random effects model. Results: We identified 895 publications out of which 37 were included in the qualitative review and 30 studies using rMT or aMT were included in the meta-analyses. The AD group had reduced rMT (Hedges’ g = –0.99, 95% CI [–1.29, –0.68], p < 0.00001) and aMT (Hedges’ g = –0.87, 95% CI [–1.50, –0.24], p < 0.00001) as compared with control groups, indicative of higher cortical excitability. Qualitative review found some evidence of increased MEP amplitude, whereas findings related to TEP were inconsistent. There was some evidence supporting an inverse association between cortical excitability and global cognition. No publications reported on the relationship between cortical excitability and NPS. Conclusion: There is strong evidence of increased motor cortex excitability in AD and some evidence of an inverse association between excitability and cognition. Future studies should assess cortical excitability from non-motor areas using TMS-EEG and examine its relationship with cognition and NPS.
A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer’s Disease Transgenic Mice
Authors: Kuwar Ram , Rolfe Andrew , Di Long , Blevins Hallie , Xu Yiming , Sun Xuehan , Bloom George S. , Zhang Shijun , Sun Dong
Published: July 2021

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and the most common type of dementia. A growing body of evidence has implicated neuroinflammation as an essential player in the etiology of AD. Inflammasomes are intracellular multiprotein complexes and essential components of innate immunity in response to pathogen- and danger-associated molecular patterns. Among the known inflammasomes, the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome plays a critical role in the pathogenesis of AD. Objective: We recently developed a novel class of small molecule inhibitors that selectively target the NLRP3 inflammasome. One of the lead compounds, JC124, has shown therapeutic efficacy in a transgenic animal model of AD. In this study we tested the preventative efficacy of JC124 in another strain of transgenic AD mice. Methods: In this study, 5-month-old female APP/PS1 and matched wild type mice were treated orally with JC124 for 3 months. After completion of treatment, cognitive functions and AD pathologies, as well as protein expression levels of synaptic proteins, were assessed. Results: We found that inhibition of NLRP3 inflammasome with JC124 significantly decreased multiple AD pathologies in APP/PS1 mice, including amyloid-β (Aβ) load, neuroinflammation, and neuronal cell cycle re-entry, accompanied by preserved synaptic plasticity with higher expression of pre- and post-synaptic proteins, increased hippocampal neurogenesis, and improved cognitive functions. Conclusion: Our study demonstrates the importance of the NLRP3 inflammasome in AD pathological development, and pharmacological inhibition of NLRP3 inflammasome with small molecule inhibitors represents a potential therapy for AD.
Convergent and Discriminant Validity of Default Mode Network and Limbic Network Perfusion in Amnestic Mild Cognitive Impairment Patients
Authors: Quattrini Giulia ,   on behalf of the PharmaCog Consortium, Marizzoni Moira , Pizzini Francesca B. , Galazzo Ilaria Boscolo , Aiello Marco , Didic Mira , Soricelli Andrea , Albani Diego , Romano Melissa , Blin Olivier , Forloni Gianluigi , Golay Xavier , Jovicich Jorge , Nathan Pradeep J. , Richardson Jill C. , Salvatore Marco , Frisoni Giovanni B. , Pievani Michela
Published: July 2021

Background: Previous studies reported default mode network (DMN) and limbic network (LIN) brain perfusion deficits in patients with amnestic mild cognitive impairment (aMCI), frequently a prodromal stage of Alzheimer’s disease (AD). However, the validity of these measures as AD markers has not yet been tested using MRI arterial spin labeling (ASL). Objective: To investigate the convergent and discriminant validity of DMN and LIN perfusion in aMCI. Methods: We collected core AD markers (amyloid-β 42 [Aβ42], phosphorylated tau 181 levels in cerebrospinal fluid [CSF]), neurodegenerative (hippocampal volumes and CSF total tau), vascular (white matter hyperintensities), genetic (apolipoprotein E [APOE] status), and cognitive features (memory functioning on Paired Associate Learning test [PAL]) in 14 aMCI patients. Cerebral blood flow (CBF) was extracted from DMN and LIN using ASL and correlated with AD features to assess convergent validity. Discriminant validity was assessed carrying out the same analysis with AD-unrelated features, i.e., somatomotor and visual networks’ perfusion, cerebellar volume, and processing speed. Results: Perfusion was reduced in the DMN (F = 5.486, p = 0.039) and LIN (F = 12.678, p = 0.004) in APOE ɛ4 carriers compared to non-carriers. LIN perfusion correlated with CSF Aβ42 levels (r = 0.678, p = 0.022) and memory impairment (PAL, number of errors, r = –0.779, p = 0.002). No significant correlation was detected with tau, neurodegeneration, and vascular features, nor with AD-unrelated features. Conclusion: Our results support the validity of DMN and LIN ASL perfusion as AD markers in aMCI, indicating a significant correlation between CBF and amyloidosis, APOE ɛ4, and memory impairment.
Pre-Loss Grief in Caregivers of Older Adults with Dementia with Lewy Bodies
Authors: Park Juyoung , Galvin James E.
Published: July 2021

Background: Pre-loss grief increases as dementia advances. Caregivers who experience pre-loss grief face risks to their own physical and psychological health. Objective: The study examined factors associated with pre-loss grief in caregivers of older adults with dementia with Lewy bodies (DLB) to determine whether overall caregiver experiences differ based on the stages of DLB in care recipients. The study also compared pre-loss grief in caregivers of DLB patients with that in caregivers of patients with Alzheimer’s disease (AD) and other dementias. Method: Using a cross-sectional design, 714 caregivers of older adults with dementia (488 DLB, 81 AD, 145 other dementias) completed an online survey on pre-loss grief. Multivariate linear regression identified risk factors associated with pre-loss grief and analysis of variance examined whether pre-loss grief in caregivers differed significantly based on type of dementia or stage of DLB. Results: Being the caregiver of a spouse, lower level of caregiver well-being, lower psychological well-being of the caregiver, and higher level of burden were associated (p < 0.005) with increased pre-loss grief in caregivers of older adults with DLB. There was no significant difference in caregiver burden, well-being, or depression according to the various stages of DLB (mild, moderate, severe, deceased) in the care recipients. There was no significant difference in pre-loss grief in caregivers of DLB care recipients compared to caregivers of patients with other dementias. Conclusion: Assessment of DLB caregivers and appropriate interventions should be conducted to reduce their burden and emotional distress to decrease the incidence of pre-loss grief.
Modified PID like fuzzy servo control applied to smart actuator based miniature Parallel Robot
Authors: Ranjith Pillai R. , Murali Ganesan
Published: July 2021

Miniature flexible parallel robots, popularly used for micro positioning application demands the use of non conventional actuators. Shape memory alloys (SMA) are popular smart actuators because of its light weight, integration compatibility, ease of actuation and high power density. Inclusion of shape memory alloy actuators to the parallel robot brings in control challenges due to its nonlinearity, coupling effects and cocontraction of antagonistic pair of actuators in the mechanism in order to achieve bi directional motion. In this paper, a PID like fuzzy controller is designed and applied to a nonlinear SMA spring actuator connected to a symmetric 2 DOF miniature parallel robot. The fuzzy rules are designed from the general response plot and modified to be applied to a parallel mechanism which involves cocontraction of antagonistic actuators. The paper has also presented the control and electrical circuit design used in the experimental set up. The fuzzy control is implemented in the hardware controller with model based position feedback and tested for the trajectory tracking characteristics of the end effector with disturbances. Experimental results are presented with quantitative analysis to show the effectiveness of the proposed controller in handling nonlinearities and disturbances compared to the conventional PID control and nonlinear Sliding mode control (NSMC). The test results has demonstrated the superior nature of proposed control over other controllers in the trajectory tracking with disturbances and also linearizing the hysteresis of controlled system.
TREC-COVID: Building a Pandemic Retrieval Test Collection
Authors: Voorhees Ellen , Kanoulas Evangelos
Published: July 2021

Assessing how good is a search engine has been an active area of development for more than three decades. During the COVID-19 pandemic however the rate of change in what people are interested in, and the availableinformation online has introduced further challenges for search. TREC-COVID introduces a benchmark collectionto evaluate search engines and provide the means to improve them under the special circumstances of a pandemic.
Nonrelativistic Open String Model – Magnetic Monopole Mass and Lifetime Values
Authors: Bevelacqua Joseph
Published: July 2021

Candidate magnetic monopole string parameters are investigated using a nonrelativistic open string model with fixed endpoints. String parameters and lifetime values are derived as a function of the magnetic monopole mass. A wide variation in string parameter and lifetime values is predicted for the various monopole mass values utilized in this paper. The monopole mass lifetime values exceed 1022 y for the 10 to 1018 MeV/c2 mass range considered in this paper.
Determination of receiver consumption characteristics using computer simulation
Authors:   Institute of Technical Mechanics NASU and SSAU, Vasyliv S.S. , Zhdanov V.S. ,   Institute of Technical Mechanics NASU and SSAU, Yevseyenko M.V. ,   Institute of Technical Mechanics NASU and SSAU
Published: July 2021

The problem of implementing the detonation mode of fuel combustion in thermal propulsion systems has been widely studied last decade. There are many works on fundamental and applied research on pulsating detonation. Solid propellant detonation engines can develop significant forces for a short time at low structural masses, and therefore they are ideal for auxiliary systems for the removal of separated rocket parts. In addition, detonation processes can be used to create control forces for correcting the trajectory of aircraft. All these facts determine the relevance of the area of work. For studying detonation installations, it is necessary to create test stands, but the design of test installations is an urgent and complex optimization problem. It is advisable to solve this problem with the help of computer simulation. In the existing experimental methods, for designing, it is necessary to determine in advance the geometric parameters of receivers and pipelines that provide the necessary gas consumption for firing tests of detonation rocket engines. The work is devoted to the development of a method for determining the flow characteristics of a receiver with a pipeline of complex configuration based on the constructed model of the stand. Based on the initial data, a computer simulation of the air leakage process from the receiver was carried out, for which the Solid Works software package was used. The places of pressure drop, maximum flow rate, and air mass flow are determined. The low value of the flow rate factor is due to the complex configuration of the pipeline with numerous bends and two bellows. Comparison of calculation results with experimental data was held. The difference between the experimental and calculated values does not exceed 3.6%. The obtained information is used to select the required value of the oxidizer excess coefficient during firing tests of detonation rocket engine models. Keywords: flow rate, gas leakage, receiver, model.
Mathematical modeling of chilling process of polymer tube billets
Authors:   Ukrainian State University of Chemical Technology, Kuzyayev I. , Mitrokhin O. ,   Ukrainian State University of Chemical Technology, Kazimirov I. ,   Ukrainian State University of Chemical Technology
Published: July 2021

There are many works about producing of polymer tubes. But less attention is paid to the process of chilling of polymer products. The chilling of polymer tube billets, as most polymer processing processes, is a non-isothermal process. This means that it is necessary to solve the heat problem. Accurate calculation of the heat balance is one of the main components for the final result of the extrusion process. The mathematical model had been created for process of chilling of polymer tube billets after extrusion in this work. Several mathematical models of heating process for heat and power equipment have been created. Different calculation schemes, methods and equations for its solution are suggested. The mathematical model for process of chilling of polymer tube billets after it extrusion can be considered an expansion of research. The mathematical model is based on cylindrical coordinate system with assumption of axisymmetric along angular coordinate. The initial problem statement considered non-stationary process. A transition was made to the differential equation in partial derivatives along two linear coordinates. Solution of this equation was found using the operation method (Laplace integral transform method). The final solution of the problem (after direct and reverse Laplace transform) was obtained from the Bessel function. It was calculated in MathCAD with the help of built-in functions and computing modules. The mathematical model was created for modeling and optimization of process of chilling of polymer tube billets. The results of calculation were presented as graphs that make it possible to characterize the adequacy of the materials. Keywords: mathematical model, balance equation, Laplace transform, program block.
Modeling of acetylene synthesis process in ChemCAD and features of SCADA connection using OPC technology
Authors:   Ukrainian State University of Chemical Technology, Levchuk І. , Mysov O. ,   Ukrainian State University of Chemical Technology, Fesenko К. ,   Ukrainian State University of Chemical Technology
Published: July 2021

The article examines the features of constructing mathematical models in modern universal modeling programs and their further use using OPC technology in control systems for processes of chemical technology based on SCADA systems. The objective is to study the features of information exchange using OPC technology between the universal ChemCAD simulator and the modern SCADA system TRACE-MODE 6 using the example of a mathematical model of a kinetic reactor for the synthesis of acetylene. To achieve this goal, a mathematical model of a kinetic reactor for the synthesis of acetylene based on a model of a continuous stirring reactor has been developed in the ChemCAD simulation software environment. The reactor was tuned and the parameters of material flows were experimentally selected. A study of the process of synthesis of acetylene was carried out according to a mathematical model, a graphical dependence of the yield of acetylene on temperature was obtained and its analysis was carried out, according to the results of which the temperature providing the maximum yield of acetylene was established. With the help of OPC technology, information exchange between the model and the control system of the acetylene synthesis process is carried out, which is based on the modern SCADA system TRACE-MODE 6. A graphical dependence is obtained describing the transient process of the system through the acetylene output channel when using a PID controller and perturbing with a change in the task. The analysis of the transient process revealed the absence of transport lag, which is explained by the calculated nature of the control object and is impossible for a real technological process. To solve the problem, an experiment was carried out, according to the results of which a method for emulating transport lag using the functionality of the information channels of the SCADA system was proposed. The graph of the transient process of the system through the acetylene outlet channel was obtained, which confirms the effectiveness of the proposed method of emulation of transport delay when using external calculation models in SCADA systems. Keywords: mathematical modeling, universal modeling programs, OPC, control systems, SCADA-based control, TRACE-MODE, ChemCAD.
Applied use of the Arduino NANO as Wi-Fi of the guided movable device
Authors:   Ukrainian State University of Chemical Technology, Lisenko V. , Vaskovets A. ,   Ukrainian State University of Chemical Technology, Dubovick T. ,   Ukrainian State University of Chemical Technology
Published: July 2021

The development of a Wi-Fi-controlled video machine using Arduino NANO is described. The connection diagram of Arduino NANO and additional modules is presented. The relevance of the topic under development is emphasized by the increasing demand for the use of remotely controlled video devices. A Wi-Fi-controlled video device (machine) was developed, which is powered by a battery that is connected to the charge controller module with microUSB. Possible battery life is 5-6 hours without recharging. In the process of developing a Wi-Fi-controlled video machine, a large amount of work was carried out, including adding the necessary libraries for the correct writing of programs and determining the necessary conditions for the functioning of the device. Program (sketch) for controlling the engines of the machine is also developed; the main components for creating the device are identified. For the mobile camera application to work, it is necessary to download the JoyLite application from the AppStore or PlayMarket; after which the smartphone “connects” to the Wi-Fi network and the SANNCE HD 720p camera. In the software part of the development of a Wi-Ficontrolled video machine using Arduino NANO in the Arduino IDE software environment, the program (sketch) was developed for the SANNCE HD 720p “JoyLite” mobile application. This program configures the signals from the stepper motors of the camera to asynchronous motors of the machine, as well as adjusting the speed of the wheels. During the tests of the device, it turned out that the Wi-Fi-controlled video machine has a sensitivity to speed impacts, namely, the speed should exceed 255 r./s. The developed Wi-Ficontrolled video machine can be used in various fields. For example, the device can be used in systems such as «Smart Home» or in security systems, or be implemented as a training project in the course of robotics. Keywords: Wi-Fi, microcontroller, Arduino NANO, video device, remotely controlled device.
DIPLOMASI BUDAYA PEMERINTAH PROVINSI KALIMANTAN SELATAN DALAM FESTIVAL BANJAR 2018-2019
Authors: Akil Salsabila Andi , Kusumawardhana Indra
Published: July 2021

Indonesia conduct cultural diplomacy activities not only by central government but also regional government, including Provincial Government of South Kalimantan. The purpose of this research is to understand how Provincial Government of South Kalimantan conducted cultural diplomacy in Festival Banjar 2018-2019. The concepts used in this research are Cultural Diplomacy by Gienow-Hecht and Donfried and Paradiplomacy by Duchacek. This research uses constructivist paradigm and qualitative research method with qualitative data analysis techniques by Miles, Huberman and Saldana. The results of this research reveal that Festival Banjar 2018-2019 is a form of cultural diplomacy carried out by sub-national actor, in this case Provincial Government of South Kalimantan. Festival Banjar 2018-2019 is a cultural diplomacy agent practice belongs to mixed model; agenda to promote South Kalimantan culture and tourism; vehicle through South Kalimantan art and floating market simulation; target audience are the diplomatic corps and foreign societies. Provincial Government of South Kalimantan as a sub-national actor also related to paradiplomacy where the implementation involves two main types of paradiplomatic activities, such as lobbying through interactive talk shows with the target audiences; and media exposure during the event.
POSTKOMODIFIKASI PORTAL BERITA DI KOMPAS.COM PADA PEMBERITAAN VAKSIN COVID-19
Authors: Bayquni Bayquni , Santoso Prasetya Yoga
Published: July 2021

The coverage of the Covid 19 vaccine on Kompas.com is the object of this research. The purpose of this study is to find out, analyze, and reveal how the political discourse in the news of the Covid 19 Vaccine and how post-commodification of information occurs through the news of the Covid 19 vaccine on Kompas.com. The technique used is documentation. This research is an interpretive qualitative research with a critical paradigm with Norman Fairclough's Critical Discourse Analysis. Discourse analysis in this theory is carried out at three levels, namely text, discursive practice, and sociocultural practice. The results showed that the political discourse that developed in the news of the Covid 19 vaccine on Kompas.com was in the practice of media commodification. Political discourse in the news of the Covid-19 vaccine is represented as an identity battle between related parties, especially in government circles. The news on the Covid 19 vaccine, narrated by Kompas.com, is very political to gain recognition, support, and representation of media ideology by turning news into a millennial industry, ammunition for political competition and political partisan identity within the government.
KONSTRUKSI REALITAS PEMBUBARAN FRONT PEMBELA ISLAM DAN DEMOKRASI
Authors: Sovianti Rina
Published: July 2021

This study aims to know the direction of democracy and know the framing of news in Republika.com and Kompas.com, as well as the implications of the dissolution of FPI to development communication. The uniqueness of this research, FPI is a mass organization with a large number of masses but does not have an organizational license. This study uses the paradigm of constructionism, which considers the reality of social life is not a natural reality. Using the Robert N. Entman method to frame news stories coming from Republika.com and Kompas.com. The difference in framing in Kompas.com media and Republika.com is the news source. Republika.com choose a news source from an Islamic background, while Kompas.com choose a news source who is competent in his field is not based on his religion. In the first framing analysis, the level of problem identification and causal interpretation, the two online media have similarities. However, in terms of moral evaluation and treatment recommendation both media have differences. In Republika.com researchers analyzed treatment recommendations is the rejection of FPI activities. FPI has no legal standing. Kompas.com, his treatment recommendation consideration of the dissolution of FPI is to maintain the existence of ideology and basic consensus of the state of Pancasila, the 1945 Constitution, the integrity of the Republic of Indonesia, and Bhinneka Tunggal Ika. Basically, the right to organize is a constitutional right. If there is no fundamental reason, the dissolution of a community organization should not exist. However, FPI is an organization that offers intolerance in the religious field.
ANALISIS RUANG PUBLIK INSTAGRAM BEMP ILMU KOMUNIKASI UNIVERSITAS NEGERI JAKARTA SEBAGAI TRANSFORMASI INFORMASI
Authors: Nabilla Febrizka , Arviani Kiki Dwi , Herlina Rizka , Safitri Dini
Published: July 2021

One of the important factors in delivering information transformation is the intensity of the followers. With the intensity of the followers that causes the information reported by an information submitted by the Instagram account of BEMP Communication Science, State University of Jakarta. The purpose of this study is to see the information transformation process that occurs on the BEMP Instagram account of the Jakarta State University for communication.  This research uses qualitative research methods with interview and observation data techniques. The results of this study indicate that Instagram of BEMP Communication Science, State University of Jakarta is a place for public spaces in statements of attitudes and arguments. In addition, the information transformation that occurs includes criticism and suggestions from his followers, this can happen because the information conveyed can influence the various opinions and responses of his followers, then what the followers think. The occurrence of this transformation made his followers more generous in visiting the Instagram account of BEMP Communication Science, State University of Jakarta, because they wanted information for themselves that could be obtained by visiting the Instagram account of BEMP Communication Science, State University of Jakarta.
ANALYSIS OF QTC PROLONGATION DUE TO BEDAQUILINE IN TUBERCULOSIS PATIENTS – A RETROSPECTIVE STUDY.
Authors: Modi Saurin , Singh Anil , Karelia Bharti
Published: July 2021

Introduction: Bedaquiline should is administered under direct observation along with standard MDR-TB regimen. Recommended dose is 400 mg once daily for 2 weeks followed by 200 mg thrice weekly for 22 weeks. After 24 weeks of Bedaquiline therapy, MDR-TB regimen should be continued as per national TB treatment guidelines. The observed prolongation of the QT interval and potentially fatal cardiac arrhythmia may or may not be related to interference with membrane associated cation transports.

Aims and objective: To analyze  QTc Prolongation in patients who received Bedaquiline in District tuberculosis center at Rajkot.

Material and method: All the patient who received and actively followed and developed QTc prolongation as Adverse Drug Reaction were included in the study. Demographic parameter and detailed information about ECG changes due to QTc Prolongation was noted from patient treatment sheet. Interim analysis was done in this study. Adverse drug reactions data was collected in Adverse Drug Reaction(ADR) form (version 1.3) by Indian Pharmacopoeia Commission. The ADR related data can be accessed through - https://vigiflow-in.who-umc.org.

Result: Total 30 patient who received Tablet Bedaquiline were included in the study. Out of which 18 (60%) were males and 12 (40%) were females, Mean age of patient was 28.3 (years) ± 11.6 SD, Mean weight of patient was 48.2 (kg) ± 5.6 SD and 2 patient  died due to cardiac arrest.

Statistical analysis: Descriptive analysis like mean, standard deviation and percentage was done using excel office version 2016.

Conclusion: Long QTc prolongation was noted more among male patients weighing 41 to 50 kg. Among all the participant, majority were having QTc prolongation and two death were observed during treatment of Bedaquiline. The patients will be further followed up for outcome analysis.

Keywords: Bedaquiline, QTc interval, adverse effect.
REVIEW ON HERBAL LOZENGES PREPARED FOR COLD AND FLU.
Authors: N Darwhekar G. , Kajal Mudgal , S Koko Sweta.
Published: July 2021

Traditional medicine and herbal formulation have been used by mankind for the care and treatment of various diseases and disorder. Throat infections are most common diseases in today’s world. However it is not taken too seriously by people long term throat infection can lead to severe throat problems pharyngitis and also cancer. The polyherbal lozenges are solid preparation that contains one or more medicaments usually during a flavored, sweetened base that are intended to dissolve or disintegrate slowly within the mouth. The benefits of they medicated lozenges is that they increase a retention time of the dosage form in mouth which increases bioavailability, reduces gastric irritation and bypasses first pass metabolism. 

Keywords: polyherbal lozenges, pharyngitis
THE SITUATION OF THE MODERN INGUSH WOMAN
Authors: Evloeva Liana M.
Published: July 2021

To date, there are no separate studies of the status of a modern Ingush woman, her position in society, etc. At the same time, there are paragraphs, fragments in the works of Ingush researchers, as well as a small number of articles published by Ingush scientists in Russian scientific journals and republican newspapers.

This article attempts to partially fill this gap - to describe the place and role of women in modern Ingush society, which have undergone significant transformations due to objective reasons (the collapse of the USSR, the Ossetian-Ingush conflict, the formation of the Ingush Republic , the strengthening of religious sentiments of the population, globalization processes, etc.)

In this work, we examined such topical issues as psychological and physical violence in the family, the reasons for this phenomenon in Ingush families; introduced new ethnographic information obtained by us during the research in 2018-2020.

We concluded that the topic of violence is relevant not only for the Ingush region, but also for the country as a whole. The lowering of the status of the Ingush was not influenced by Islam, as many authors wrote about, but, rather, by an incorrect interpretation of the norms of religion. Today, women in Ingushetia are becoming more and more independent, as they have become economically independent. Despite this, traditional attitudes continue to play an important role in the life of the Ingush. This is evidenced by the fact that women prefer to marry as a second wife to an Ingush, rather than the first to a person of a different nationality.
Integrasi Servqual Dan Ahp Untuk Evaluasi Kualitas Layanan Dekranasda
Authors: Mahmudi A Aviv
Published: July 2021

Achieving superior service quality is the main concern of all service providers, so that service providers are urged to provide high quality customer-oriented services. The purpose of this study was to analyze the quality of customer service at Dekranasda Rembang, using the Servqual and Analitycal Hierarchy Process (AHP) methods. Servqual is used to see customer perceptions and expectations on the five dimensions of servqual including Physical Evidence (Tangibles), guarantee (Reliability), Responsiveness (Responsiveness), Assurance (Assurance) and Empathy (Emphaty). While AHP is used to weight each dimension and criteria. The results showed that there were 10 service criteria that had to be improved immediately by Dekranasda, so as to improve customer quality.
MEASUREMENT AND ANALIZE REFLECTION COEFFICIENT OF THINGS AT FREQUENCY 1260 MHz
Authors: Sulistyowati Dyah , Eristiana Erwin
Published: July 2021

px; "> <Reflection wave by objects (things) that affected phases changing from wave and influenced thepower of wave signal. The difference kind of things will give different reflection coefficient. Wavesignal that’s happen is depends on the kind of the thing. There are three nature of the object that’scontinuing, absorb and reflecting the wave signal. Reflected coefficient with negative value that’smeans the object could reflecting the signal and the positive value means the object could absorb orcontinuing the wave signal.Reflection coefficient data could be saved in a database that its data from kinds of thing in tableform could be access anytime its needed, so we can easily to find out the value of reflection coefficient.Process of data relation in database system used SQL as programming language. Keywords: Reflection coefficient, kinds of object, database system, SQL.
DESIGN OF ARTIFICIAL NEURAL NETWORK SOFTWARE FOR PREDICTING THE HEALTH GRADE IN A TELEPHONE EXCHANGE
Authors: Yuwono Wiratmoko , Herlambang Yodik Iwan , Purnomo Mauridhi Hery , Kristalina Prima
Published: July 2021

Application of artificial neural network software ( ANN ) has been implemented forpredicting many thing and replace the conventional ways of predicting method using linearregression. Back Propagation algorithm can be used to reach the result of the program thatcan predict the telephone exchange health grade according to the data that has beenrecorded before. By predicting each parameter that has correlation to the telephoneexchange health grade, we can predict the telephone exchange health grade in the nextperiod.Kata kunci : jaringan syaraf tiruan, propagasi balik, nilai kesehatan sentral.
RANCANG BANGUN SISTEM KONTROLTEMPERATUR BERBASIS LOGIKA FUZZY
Authors: Susilo Ardiyanto Happy , Purwati Ninik , Astawa I.G. Puja , Fariza Arna
Published: July 2021

Kontroler fuzzy merupakan salah satu metode sistem kontrol yang menyatakan hokum operasional dari suatu sistem dengan ungkapan bahasa, bukan dengan persamaan matematis. Pada proyek akhir ini, kontroler fuzzy digunanakan sebagai kontrol temperatur yang diharapkan mampu mengontrol temperatur sesuai dengan setting point yang diinginkan. Prinsip kerjanya yaitu sinyal masukan dari plant yang berupa sinyal error dan diferensial error diolah oleh sistem logika fuzzy melalui tiga proses ; fuzzyfikasi, rule base dan defuzzyfikasi, menjadi sinyal kontrol yang mampu menentukan sudut pengapian dari SCR dalam menyalakan heater sebagai pemanas . Proses looping berlangsung terus menerus sampai didapatkan nilai temperatur yang sesuai atau mendekati dengan setting point yang dimasukkan.Keyword : Fuzzy, SCR, Kontroller
ANALISIS TARGET & REALISASI TERHADAP BEBERAPA JENIS PAJAK DI KABUPATEN PATI JAWA TENGAH
Authors: Arifin Muhyiddin Zainul
Published: July 2021

Untuk meningkatkan kemandirian pertumbuhan ekonomi Daerah. Maka PemerintahDaerah Pati harus berupaya secara optimal bagaimana meningkatkan pertumbuhan ekonomiuntuk meningkatkan PAD melalui komponen penerimaan pajak daerah berWilayah konsumsiyang berhubungan dengan pertumbuhan ekonomi.Penelitian ini dilakukan pada bagian pengelolaan PBB sektor perdesaan danperkotaan di Kabupaten Pati serta beberapa instansi terkait. Melihat demikian luasnyapermasalahan yang ada, maka sasaran pengamatan dalam penelitian ini akan difokuskan padapengelola PBB dan para pejabat di Kantor Dispenda Kabupaten Pati.Data yang diperoleh dalam penelitian ini akan dianalisis dengan menggunakananalisis regresi sederhana dengan bantuan program eviews, elastis pajak daerah, analisis MRPmelalui dua pendekatan yaitu rasio pertumbuhan wilayah referensi (RPR) dan rasiopertumbuhan wilayah studi (RPS), analisis location quotient (LQ), dan analisis overlay.Hasil penelitian menunjukkan bahwa tingkat pertumbuhan penerimaan PBB sektorperdesaan dan perkotaan di Kabupaten Pati selama periode 2000/2001-2004/2005berfluktuatif. Terlihat bahwa pada periode 2000-2004 mengalami penurunan dari tahunsebelumnya sebesar Rp491.594.820, atau turun sebesar 10,73%, kemudian periode 2000/2001mengalami kenaikan dari tahun sebelumnya sebesar Rp366.735.698 atau naik sebesar 8,96%,pada periode 2004/2005 terjadi penurunan sebesar Rp146.491.658 atau berkurang 3,30%,selanjutnya pada periode 2001/2002 terjadi kenaikan sebesar Rp258.142.522 atau naik 5,6%sehingga rata-rata pertumbuhan sel9ma periode pengamatan sebesar 1,78%. Demikian pulahalnya dengan wajib pajak yang juga mengalami fluktuatif dengan rata-rata pertumbuhan0,50%.Kata kunci : analisis MRP, analisis Location quotient, analisis overlay.
HUBUNGAN ANTARA PEMANFAATAN INTERNET SEBAGAI SUMBER BELAJAR DENGAN PRESTASI BELAJAR MAHASISWA SEMESTER III PRODI DIII KEBIDANAN SUTOMO SURABAYA
Authors: Artati Yuni , - Tumirah , - Suparmo
Published: July 2021

Seiring dengan perubahan paradigma pembelajaran, maka keberhasilan kegiatan belajar mengajar di perguruan tinggi tidak hanya ditentukan oleh faktor pengajar/dosen, melainkan sangat dipengaruhi oleh keaktifan mahasiswa. Belajar sebagai bagian dari aktifitas mahasiswa merupakan perubahan yang relative permanen dalam perilaku atau potensi perilaku sebagai hasil dari pengalaman atau latihan yang diperkuat.             Internet sebagai salah satu sumber belajar dari adanya perkembangan teknologi informasi menjadi sangat berperan untuk meningkatkan prestasi belajar mahasiswa. Secara umum masih banyak mahasiswa yang belum menggunakan internet sebagai sumber belajar. Walaupun ada masih terbatas pemanfaatannya hanya untuk komunikasi dan hiburan. Sedangkan faktor-faktor yang mempengaruhi prestasi belajar seorang mahasiswa baik internal maupun eksternal seperti: kecerdasan emosional, minat dan bakat, metode pembelajaran, sarana dan prasarana(Internet), motivasai, cara belajar, dan kecerdasan intelektual. Untuk itu perlu dilakukan penelitian apakah ada hubungannya pemanfaatan internet terhadap prestasi mahasiswa.           Penelitian ini menggunakan pendekatan analitik, karena bertujuan untuk menganalisis, menjelaskan suatu hubungan, menguji berdasarkan teori yang ada  dipakai untuk tujuan eksplorasi. Penelitian ini bertujuan melakukan pengukuran variabel independent dan dependent yang sesuai dari obyek yang diteliti. Analisis Statistik yang digunakan adalah uji Korelasi Pearson Product moment dengan taraf signifikansi 0,05.Hasil analisis korelasi terlihat bahwa nilai korelasi antara pemanfaatan internet sebagai sumber belajar dan nilai indeks prestasi mahasiswa semester III Prodi DIII Kebidanan Sutomo Surabaya sebesar 0,026,  yang memiliki hubungan korelasi sangat lemah.  Hal ini berarti terdapat hubungan yang sangat lemah antara pemanfaatan sumber belajar internet dengan nilai indeks prestasi mahaisiswa sehingga pemanfaatan internet sebagai sumber belajar tidak memberikan  pengaruh sangat nyata (signifikan) terhadap indeks prestasi mahasiswa semester III Prodi DIII Kebidanan Sutomo Surabaya. Kata Kunci : Sumber belajar Internet, Korelasi Pearson Product Moment, Indeks Prestasi
JARINGAN AKTIF : MASA DEPAN JARINGAN KOMPUTER DAN KOMUNIKASI
Authors: Sufaidah Siti
Published: July 2021

Penelitian ini membahas tentang paradigma baru dalam jaringan komputer dan komunikasi yang disebut dengan Jaringan Aktif (Active Networks). Pembahasan mengenai inisiasi ide tentang Jaringan Aktif ini lima tahun yang lalu, hingga ke perluasan, diterimanya ide tersebut untuk dikembangkan oleh masyarakat komputasi jaringan komputer, dan perkembangannya dibahas dalam penelitian ini. Tujuan dari penulisan penelitian ini adalah membahas fakta bahwa perkembangan teknologi komputer dan komunikasi berjalan sangat cepat dan mempunyai karakteristik kemajuan yang sangat berbeda dengan ilmu-ilmu yang sudah memiliki metodologi penelitian yang mapan seperti Teknik Sipil, llmu Bahan, Kedokteran, Ilmu-ilmu Sosial Ekonomi, dan ilmu lainnya. Karakteristik perkembangan ilmu pengetahuan di bidang yang telah membawa revolusi besar bagi peradaban umat manusia ini, yang menjadikan Internet sebagai tulang punggung perkembangan ekonomi, perlu di evaluasi, untuk menjadi pertimbangan bagi kebijakan Riset dan Teknologi di Indonesia. Dari penelitian ini dapat disimpuikan bahwa karakteristik dari perkembangan suatu bidang penelitian dalam bidang komputasi sangat berbeda dengan karakteristik sejarah perkembangan ilmu pengetahuan bidang-bidang lainnya.Kata Kunci : Jaringan aktif, Komunikasi & Komputer
Pengaruh Kombinasi Pemberian Tablet Fe dan Jus Jambu Biji terhadap Kenaikan Kadar Hemoglobin Mahasiswi Jurusan Kebidanan
Authors: Saudia Baiq Eka Putri , Putri Winda Astria
Published: July 2021

Menurut data hasil Riskesdas tahun 2018 presentasi ibu hamil anemia banyak pada usia 15-24 tahun sebesar 84,6%,usia 25-34 tahun sebesar 33,7%, usia 35-44 tahun sebesar 33,6%, dan usia 45-54 tahun sebesar 24%. Dari data tersebut umur tertinggi ibu hamil yang menderita anemia adalah ibu hamil yang berusia remaja yaitu 15-24 tahun. Penelitian ini bertujuan untuk mengidentifikasi pengaruh pemberian tablet Fe dan jus jambu biji terhadap kadar hemoglobin mahasiswi Jurusan Kebidanan Poltekkes Kemenkes Mataram. Rancangan penelitian yang digunakan adalah Quasi Eksperiment dengan menggunakan Pre Post Test control Grup Design. Metode pengambilan sampel dalam penelitian ini menggunakan purposive sampling dengan total sampel 30 mahasiwi. Sampel dibagi menjadi 15 orang pada kelompok kontrol diberikan tablet Fe dan 15 orang pada kelompok intervensi diberikan tablet Fe dan jus jambu biji. Data hemoglobin responden dikumpulkan sebelum dan sesudah pemberian intervensi menggunakan Easy Touch Blood Hemoglobin. Analisa data menggunakan uji paired t-test dan independent t-test. Hasil menunjukkan rata-rata kadar hemoglobin mahasiswi yang hanya mendapatkan tablet Fe sebesar 0,20 gr/dL. Rata-rata kadar hemoglobin mahasiswi yang mendapatkan tablet Fe dan jus jambu biji sebesar 0,76 gr/dL. Hasil uji statistik menggunakan independent t test diperoleh p value yaitu 0,000. Dapat disimpulkan bahwa pemberian Fe kombinasi jambu biji lebih efektif untuk meningkatkan kadar hemoglobin daripada pemberian Fe saja.