bluuebunny/crossref_metadata_2025 huggingface dataset:
A Mixed Model Approach for Estimating the Optimal Food Fortification of Vitamin D: Experiment Based on Mashhad Cohort Study in Iran
Authors: Pourmohamadkhan Marjan , Khorasanchi Zahra , Ghazizadeh Hamideh , Sedighnia Atefeh , Kiani Behzad , salemi Omid , Ferns Gordon , Rostam Niakan Kalhori Sharareh , Ghayour-Mobarhan Majid
Published: January 2024

Background: Vitamin D deficiency is a prevalent problem in worldwide healthcare related to several system disorders. Food fortification as a solution is associated with several challenges including insufficient coverage of the entire population, required degree of fortification, the vehicles used for fortification and potential toxicity. This study aimed to determine the optimal amount of vitamin D for fortification without surpassing the upper intake level (UL) of intake at the 95th percentile of the Iranian population and compare two methods of food fortification. Methods: This study is aimed to develop a model of two different fortifying approaches related to an available dataset called MASHAD cohort study. The dataset comprised demographic and nutritional data of 9704 Iranian individuals living in the Greater Mashhad region. The first approach was a computational method necessary to implement a range of eight foods and calculate the optimal approach. In the second case, we used the European formula method called ILSI. Results: To find the appropriate value for fortification, we calculated the consumption of 400 IU and 1000 IU supplements of vitamin D. Three micrograms per 100 g in each food was the optimal output. We also used Flynn and Rasmussen’s formula on our data. Using these methods, we found that 2.1 micrograms per 100 kcal provides the best result. Hence, using the two different approaches, the results appear to be consistent and promising. Conclusion: One interesting finding was that supplement consumption did not greatly affect the impact of fortification. This observation may support the hypothesis to determine the amount of fortification, and we can ignore the study population’s supplement consumption.
Translation, Cultural Adaptation, Validation and Reliability of Persian Left Ventricular Dysfunction–36 Questionnaire
Authors: Vakhshoori Mehrbod , Bondariyan Niloofar , Emami Sayed Ali , Sadeghpour Niyousha , Khanizadeh Farbod , Emami Mahmood , Shafie Davood
Published: January 2024

Background: The left ventricular dysfunction 36 (LVD-36) questionnaire is considered to be a tool to assess the impact of left ventricle impairment on patients’ daily life. This methodological study was aimed to translate and assess the validity and reliability of the Persian draft of the LVD-36 questionnaire among Iranian heart failure (HF) patients. Methods: We recruited stable HF patients who referred to an outpatient heart clinic in Isfahan, Iran. The LVD-36 questionnaire was translated using the forward-backward method. Twenty HF patients were recruited for content validity assessment and were asked to express their opinions about the comprehensibility and meaningfulness of each item. We invited 14 experts to assess validity through content validity index (CVI) and content validity ratio (CVR). Reliability was assessed by Cronbach’s alpha and intraclass correlation coefficient (ICC), with the latter evaluated after invitation of the participants to complete the questionnaire for the second time. Results: The translation process was performed uneventfully without any significant alterations. A total of 150 HF patients were recruited to assess the reliability of the questionnaire in this study (age: 64.6±16 years, males: 58.6%). All items had acceptable CVI and CVR, ranging 0.85–1.00 and 0.57–1.00, respectively. Cronbach’s alpha was 0.971. All participants completed the questionnaire for the second time with no missing data. Test-retest reliability revealed an excellent ICC value of 0.981 (95% CI: 0.977–0.985). Conclusion: The Persian version of the LVD-36 questionnaire is a simple, valid and reliable tool for evaluating the impact of left ventricle impairment on the well-being of Iranian HF patients.
14-3-3η Proteins as a Diagnostic Marker, Disease Activation Indicator, and Lymphoma Predictor in Patients with Primary Sjögren Syndrome
Authors: Kor Ahmet , Yalçın Merve , Erten Şükran , Maraş Yüksel , Oğuz Esra Fırat , Doğan İsmail , Atalar Ebru , Başer Salih , Erel Özcan
Published: January 2024

Background: Primary Sjögren syndrome (PSS) is a chronic, autoimmune, and lymphoproliferative disease of the connective tissue. In patients with PSS, the risk of developing B-cell non-Hodgkin lymphoma (NHL) increases dramatically, with a prevalence of approximately 5%. The 14-3-3 protein isoforms are phospho-serin/phospho-threonine binding proteins associated with many malignant diseases. This study aimed to evaluate the relationship between disease activity parameters and markers predicting lymphoma development in patients with PSS and 14-3-3η proteins. Methods: This study was designed as an analytical case-control study. A total of 57 PSS patients and 54 healthy volunteers were included in the study. The European League Against Rheumatism (EULAR) Sjögren syndrome disease activity index (ESSDAI) was used to assess systemic disease activity in PSS. Receiver operating characteristic (ROC) analysis was used to test the diagnostic accuracy measures of the analytical results. Multivariable linear regression analysis was used to evaluate the effects of independent variables on the 14-3-3η protein. Results: The 14-3-3η protein serum levels were found to be significantly higher in PSS (2.72 [2.04-4.07]) than healthy controls (1.73 [1.41-2.43]) (P<0.0001). A significant relationship was found between 14-3-3η protein levels and ESSDAI group (β=0.385, 95%CI=0.318-1.651, P=0.005), hypocomplementemia (C3 or C4) (β=0.223, 95% CI=0.09-1.983, P=0.048) and purpura (β=0.252, 95% CI=0.335-4.903, P=0.022), which are accepted as lymphoma predictors. A significant correlation was found between PSS disease activity score ESSDAI and 14-33η protein (β=0.496, 95% CI=0.079-0.244, P=0.0002). Conclusion: 14-3-3η proteins are potential candidates for diagnostic marker, marker of disease activity, and predictor of lymphoma in PSS patients.
Insights into Organochlorine Pesticides Exposure in the Development of Cardiovascular Diseases: A Systematic Review
Authors: Mohammadkhani Mohammad Ali , Shahrzad Soraya , Haghighi Mehrdad , Ghanbari Reza , Mohamadkhani Ashraf
Published: January 2024

Many human diseases such as cancer, neurological diseases, autism and diabetes are associated with exposure to pesticides, especially organochlorine pesticides. However, pesticide exposure is also associated with cardiovascular disease (CVD) as the leading cause of death worldwide. In this systematic review, results on the link between organochlorine pesticide pollution and CVD were collected from databases (Medline (PubMed), Scopus and Science Direct) in May 2022 from studies published between 2010 and 2022. A total of 24 articles were selected for this systematic review. Sixteen articles were extracted by reviewers using a standardized form that included cross-sectional, cohort, and ecological studies that reported exposure to organochlorine pesticides in association with increased CVD risk. In addition, eight articles covering molecular mechanisms organochlorine pesticides and polychlorinated biphenyls (PCBs) on cardiovascular effects were retrieved for detailed evaluation. Based on the findings of the study, it seems elevated circulating levels of organochlorine pesticides and PCBs increase the risk of coronary heart disease, especially in early life exposure to these pesticides and especially in men. Changes in the regulatory function of peroxisome proliferator-activated γ receptor (PPARγ), reduction of paroxonase activity (PON1), epigenetic changes of histone through induction of reactive oxygen species, vascular endothelial inflammation with miR-expression 126 and miR-31, increased collagen synthesis enzymes in the extracellular matrix and left ventricular hypertrophy (LVH) and fibrosis are mechanisms by which PCBs increase the risk of CVD. According to this systematic review, organochlorine pesticide exposure is associated with increased risk of CVD and CVD mortality through the atherogenic and inflammatory molecular mechanism involving fatty acid and glucose metabolism.
Prevalence of Subdural and Epidural Hematoma in Head Trauma Patients: A Cross-sectional Study
Authors: Morovatshoar Reza , Tabibzadeh Dezfouli Seyed Ashkan , Hosseini Teshnizi Saeed , Sheybani-Arani MohammadHosein , Khajavi-Mayvan Fatemeh , Salimi Asl Ali , Sahafibandary Maryam , Yazdani Reza
Published: January 2024

Background: Epidural hematoma (EDH) and subdural hematoma (SDH) are common complications after traumatic brain injury. Intracranial hematomas can be without complications or associated with life-threatening conditions, including midline shift, cerebral edema, intracerebral ischemia, and increased intracranial pressure. This study aimed to investigate the prevalence of EDH and SDH in patients with head trauma attending the emergency department. Materials and Methods: This descriptive cross-sectional study included 146 patients with head trauma referred to the Emergency Department of Shahid Mohammadi Hospital, Bandar Abbas, in 2021. Patients’ data, including age, gender, Glasgow Coma Scale (GCS) on admission, mechanism of trauma, type of hematoma, length of intensive care unit (ICU) stay, outcome (recovery/death), and neurosurgery requirements were extracted from their medical files. Results: The mean age of the participants was 20.97±15.05 years, of whom 114 (78.1%) were male. EDH and SDH were observed in 7.5% and 11% of patients, respectively. The most common mechanism of trauma was traffic accidents (39%), followed by falls (28.1%) and assaults (13%). Moreover, 11% of the patients needed neurosurgical intervention. Most patients recovered (95.9%), and 4.1% died. The mean GCS on admission was 13.47±2.34. Furthermore, SDH was significantly higher in the patients who died (P=0.001) and those aged≥18 years (P=0.028). Conclusion: The results of the current study showed a higher prevalence of SDH compared to that of EDH. Both hematoma types appeared to correlate with the mechanism of trauma, ICU admission, GCS on admission, and neurosurgery requirement, while SDH was associated with age and death.
Metabolic Syndrome in Postmenopausal Women and Its Early Detection
Authors: Aich Shritama , Saha Avijit , Ghosh Sandip , Mukherjee Kheya , Sur Tapas Kumar
Published: January 2024

Menopause is the end of the menstrual cycle in a woman’s life. At menopause, a series of physiological changes occur in women’s bodies and hormonal changes are the main cause of these changes. Several metabolic changes occur in the body at that particular period, and the constellation of these changes is referred to as metabolic syndrome. Postmenopausal women have higher chances of developing these metabolic syndromes such as cardiovascular diseases (CVDs), hypertension, diabetes, and changes in the lipid profile mostly due to changes in the level of estrogen. Thus, having an overview of common metabolic disorders, their detection, and their management can improve the overall quality of life and decrease the mortality rate in the postmenopausal group. This review has discussed the commonly occurring metabolic disorders at menopause and how these disorders can be managed and treated.
Treatment adherence and its relationship with health literacy in patients with mood disorders in hospitals affiliated with Isfahan University of Medical Sciences in 2022: A cross-sectional study
Authors: Mousavi Sayed Reza , Fereidooni Moghadam Malek , Jamalinasab Aliasghar , Farahani Elaheh , Yousefi Bahareh , Hassanvand Pegah
Published: January 2024

Background and aims: Mood disorders include major depression and bipolar disorder. Treatment adherence and health literacy are very important in these patients because they may affect their quality of life, performance, and recovery. Therefore, this study aims to determine the level of treatment adherence and its relationship to health literacy in patients with mood disorders. Methods: This cross-sectional-correlation study was conducted on 120 patients with mood disorders in 2021-2022. Data were collected using the treatment adherence questionnaire of Ziaee et al and the Health Literacy of Iranian Adults (HELIA) questionnaire. Finally, the collected data were analyzed in SPSS-16 software. Results: Findings showed that patients with mood disorders had moderate treatment adherence (51.53±8.31) and insufficient health literacy (61.31±15.91). The results indicated that treatment adherence had a significant relationship with health literacy in patients with mood disorders (P<0.05, r: 0.298). Conclusion: Inadequate health literacy in patients with mood disorders shows that health literacy should be considered in improving mental health. Therefore, it is recommended that by promoting the health literacy of these patients and identifying its challenges, treatment adherence in patients with mood disorders be improved.
Psychological and psychiatric issues in patients diagnosed with cancer: A review study
Authors: Vaziri Harami Roya , Ghorbani Anna , Ghaffariyan Shahrzad , Asgari Navid , Akbari Mohammad , Ranjbaran Farideh , Karimi Aliabadi Hakimeh , Jamali Nima
Published: January 2024

Getting diagnosed with cancer can be a tremendous stressor; it can even be recognized as an emotional trauma that can lead to several mental health problems and dysfunction in many aspects of one’s life. Recent studies demonstrated that mental health issues can affect the quality of life, compliance with cancer treatment, medication efficacy, mortality rate costs of health services, and economic loss of cancer patients. In this review study, we gathered the literature by searching the databases, including Web of Science, Scopus, and PubMed. Google Scholar search engine was also used to make an extensive search strategy. We chose articles based on reporting the prevalence rate of mental health problems and the psychological and psychiatric problems that can influence the treatment of patients with cancer. The literature review showed that one-third of all cancer patients suffer from psychiatric disorders and psychological dysfunctions, and the most common mental disorders that can be comorbid with cancer are depression spectrum and anxiety disorders.
Scripting Imagination: The AI Revolution in Creative Writing
Authors: Mannarsamy N.
Published: January 2024

Creative writing has always been an art form deeply rooted in human imagination and expression. However, with the advent of Artificial Intelligence (AI), creative writing is experiencing a major transformation. This essay explores the multidimensional relationship between AI and creative writing, examining the applications, advantages, limitations, and ethical considerations that accompany this technological shift. As AI becomes an increasingly integrated part of our literary landscape, it challenges the traditional boundaries of storytelling and writing.
Metamorphosis as the Crux of the Character Vandiya Devan in Kalki’s Ponniyin Selvan
Authors: Kamalakkannan K.M
Published: January 2024

Human life is inherently compared. Man compares his life to other people’s lives. He has the intrinsic moral ability to balance the evil and good thoughts that bubble up from the depths of his mind. This is how literature and art have developed throughout all cultures. They have all been created in a comparative way. Literature has been a tool for teaching people about life and how it should and should not be. Images, symbols, and recurring themes from everyday life are used to illustrate the concepts. We refer to them as archetypes. They are the archaic pictures from global mythology that predominate in everyone’s minds. The journey of the hero is one such motif that has been predominating in the literary genre. This style totally maintains the hero’s quest as its foundation. They are fiercely patriotic toward their respective national identities. The great heroes of any nation are represented by their characters. Characters from the film “Ponniyin Selvan” such Aditya Karikalan, Arulmozhi Varman, and Vanthiyathevan are well-known for their quests, adventures, feuds, fights, and wars. Their quest and triumph serve as ideal illustrations of the hero archetype’s journey. In Kalki’s Ponniyin Selvan, the transformation of the character Vanthiya Devan is extra ordinary. Thus, the present paper explores Vanthiya Devan’s transformation and achievements in the novel and film.
Byte-Sized Evolution: Navigating the Linguistic and Cultural Dynamics of Social Media
Authors: Raghavan Lakshmi K , Lourdhu Mary D.
Published: January 2024

In the ethereal realm of social media, where the digital and the tangible collide, a linguistic and cultural metamorphosis unfolds, redefining the essence of human communication and societal dynamics. This abstract encapsulates the intricate ballet between language and culture in the vast expanse of online platforms, exploring the transformative power, paradoxes and challenges embedded in this digital world. At the linguistic crossroads, social media acts as both provocateur and preservationist. The brevity demanded by character limits births a new lexicon, where abbreviations and emojis transcend the informal to entwine with the formal. Linguistic evolution becomes a pulsating force, challenging traditional norms while offering a canvas for conciseness in an interconnected world. The influencer phenomenon adds an avant-garde layer, as online personas shape linguistic trends, creating digital subcultures that infiltrate mainstream discourse.Cultural narratives unfold through the alchemy of hashtags, becoming tools of expression and catalysts for societal change. The paradox of globalization surfaces, with social media as both a bridge and a potential bulldozer of linguistic diversity. The dominance of English and Western cultural influence raises concerns, but online communities emerge as bastions for the preservation and revitalization of endangered languages. Yet, the digital landscape is not without its pitfalls. Misinformation, like a shadow, looms large, challenging the integrity of language and the trust in societal narratives. The influencer’s power becomes a double-edged sword, fostering digital subcultures while also igniting ethical debates on cultural commodification and misinformation spread. As societal fault lines are exposed, the echo chamber effect emerges, testing social media’s potential to either unite disparate cultures or deepen existing divides. The journey through this digital linguistic and cultural landscape demands a nuanced approach—embracing innovation while safeguarding against oversimplification, misinformation and cultural appropriation.
SERMAYE YAPISININ FİNANSAL PERFORMANSA OLAN ETKİSİNİN İNCELENMESİ: BİST TAŞ, TOPRAK (XTAST) ENDEKSİ ÜZERİNE BİR UYGULAMA
Authors: Düzakın Hatice , Yılmaz Özekenci Süreyya
Published: January 2024

Çalışmanın amacı, BİST Taş, Toprak endeksinde yer alan işletmelerin varlıklarının finansmanında kullandığı kaynakların bileşimini ifade eden sermaye yapısının finansal performansa olan etkisini ortaya koymaktır. Bu kapsamda çalışmada 2013-2022 dönemine ait yıllık finansal veriler panel regresyon yöntemi kullanılarak analiz edilmiştir. Çalışmada öz sermaye karlılığı, aktif karlılık ve piyasa değeri/defter değeri oranları bağımlı değişken olarak belirlenmiş ve 3 farklı model oluşturulmuştur. Sermaye yapısı ile ilgili gösterge olarak modellerde finansal kaldıraç oranı, uzun ve kısa dönemli borç oranları kullanılmıştır. Ayrıca modellere maddi duran varlık oranı ve işletme büyüklüğü kontrol değişken olarak eklenmiştir. Panel veri analizi kullanılarak yapılan yönteminin sonuçlara göre; (1) Öz sermaye karlılığının bağımlı değişken olduğu Model 1 için sermaye yapısı ile finansal performans arasında istatistiksel olarak anlamlı ve pozitif yönlü bir ilişki vardır, (2) Aktif karlılığın bağımlı değişken olduğu Model 2 için sermaye yapısı ile finansal performans arasında istatistiksel olarak anlamlı ve pozitif yönlü bir ilişki vardır, (3) Piyasa değeri/defter değerinin bağımlı değişken olduğu Model 3 için sermaye yapısı ile finansal performans arasında istatistiksel olarak anlamlı bir ilişki tespit edilememiştir.
Remote work in the Finnish Defence Forces: Employees’ experiences of changes in organisational culture
Authors: Kähkönen Tiina
Published: January 2024

This paper investigated what changes took place in the organisational culture of the Finnish Defence Forces during the COVID-19 pandemic, and also afterwards when remote work has remained permanently available to staff. A total of 468 employees of the Finnish Defence Forces participated in the study by reporting their experiences of changes in organisational culture. In the analysis of qualitative data, the Gioia methodology, which classifies the data into categories and themes, was used. Remote work creates challenges for leadership, and more equality, changed management competence, and remote work management skills were expected from management. However, it would seem that the organisational culture in the Finnish Defence Forces has developed in such a way that trust within the organisation is even stronger than before. Remote work has developed the personnel’s skills in managing digital tools as well as the employer image of the Finnish Defence Forces in the eyes of their personnel. This is the first study to map employees’ experiences of remote work from the perspective of changes in organisational culture in the Finnish Defence Forces. The research provides novel information that can be utilised in developing the operations and management of organisations. The Finnish Defence Forces have taken significant steps towards a modern work community. There are still some challenges to be solved in terms of how to improve leadership of remote work. A particularly important resource in resilience to change is the trust that is manifested in the organisational culture of the Finnish Defence Forces.
Analisis Penerapan PSAK No 24 Mengenai Imbalan Kerja Pada CV Aneka Ritelindo Manado
Authors: Awal Indahsari Berlianie , Elim Inggriani , Weku Priscilia
Published: January 2024

Abstrak: Pemberian imbalan kerja tidak hanya akan mempengaruhi pekerja yang akan berdampak pada produktivitas perusahaan tetapi juga akan berdampak secara finansial jika tidak disikapi dengan bijak oleh perusahaan. Karena pengaruhnya yang besar terhadap perusahaan, maka perlu dilakukan pengungkapan yang benar sesuai dengan standar akuntansi keuangan yang berlaku umum. Penelitian ini bertujuan untuk mengetahui bagaimana penerapan psak no 24 mengenai imbalan kerja pada CV Aneka ritelindo manado. Peneliti mengambil objek penelitian pada CV Aneka ritelindo manado. Metode analisis data yang digunakan dalam penelitian ini adalah analisis deskriptif kualitatif. data penelitian ini diperoleh dari data primer dan sekunder. teknik pengumpulan data berupa penelitian kepustakaan dan penelitian lapangan yaitu wawancara langsung dengan pihak perusahaan CV Aneka ritelindo manado yaitu direktur utama. Hasil penelitian pada CV Aneka ritelindo manado dapat disimpulkan bahwa imbalan kerja pada CV Aneka ritelindo manado dapat dikategorikan ke dalam empat kategori berdasarkan PSAK No. 24 yaitu imbalan kerja jangka pendek, imbalan pascakerja, imbalan jangka panjang lainnya dan pesangon. dari keempat imbalan kerja tersebut hanya imbalan kerja jangka pendek dan pesangon yang diterapkan dan dilaporkan sesuai dengan PSAK No. 24. Sedangkan kedua imbalan kerja lainnya belum diterapkan dan dilaporkan sesuai dengan PSAK No. 24. Kedua imbalan kerja lainnya belum diterapkan sehingga tidak perlu disesuaikan dengan PSAK No. 24.
PENGARUH INFLUENCER LOKAL SEBAGAI CELEBRITY ENDORSEMENT TERHADAP NIAT KONSUMEN MELAKUKAN PEMBELIAN ONLINE
Authors: Mansyur Vindy Ratna
Published: January 2024

Tujuan penelitian ini adalah untuk mengetahui pengaruh attractiveness terhadap niat konsumen, untuk mengetahui trustworthiness, terhadap niat konsumen, untuk mengetahui pengaruh expertise terhadap niat konsumen, untuk mengetahui pengaruh Pengaruh influencer lokal sebagai celebrity endorsment terhadap niat konsumen melakukan pembelian online. Penelitian ini menggunakan pendekatan kuantitatif, dimana jumlah sampel sebanyak 100 responden. Hasil penelitian menunjukan dari hasil uji secara simultan di peroleh bahwa attractiveness, trustworthiness, dan expertise terhadap niat konsumen melakukan pembelian online. Dan hasil uji parsial di peroleh bahwa variabel attractiveness berpengaruh secara positif dan signifikan terhadap niat konsumen terhadap pembelian online, sedangkan variabel trustworthiness berpengaruh secara positif dan signifikan terhadap niat konsumen terhadap pembelian online. Dan expertise berpengaruh secara positif dan signifikan terhadap niat konsumen terhadap pembelian online
Kata Kunci: attractiveness, trustworthiness, expertise.
PENERAPAN MARKETING MIX 7P PADA CV.INDOCIPTA KARYA GEMILANG LEILEM
Authors: Oroh Gilbert J. , Nelwan Olivia , Lumintang Genita
Published: January 2024

Salah satu bentuk penerapan bauran pemasaran yang mampu mendukung dalam memasarkan produk untuk menciptakan kepuasan pelanggan yaitu penggunaan bauran pemasaran 7P, meliputi produk, harga, promosi, dan tempat/distribusi, orang, proses, dan bukti fisik. Dengan melakukan penerapan bauran pemasaran yang akurat melalui pemanfaatan peluang dalam meningkatkan penjualan, maka posisi atau kedudukan perusahaan di pasar dapat ditingkatkan atau dipertahankan. Penelitian ini bertujuan untuk mengetahui penerapan bauran pemasaran yang dilakukan oleh CV. Indocipta Karya Gemilang Leilem. Metode penelitian yang digunakan adalah penelitian kualitatif deskriptif, pengambilan data menggunakan teknik wawancara observasi dengan sampel pemilik, karyawan dan pelanggan pada CV. Indocipta Karya Gemilang Leilem. Hasil penelitian ini menunjukkan bahwa penerapan bauran pemasaran yang dilakukan CV. Indocipta Karya Gemilang Leilem untuk meningkatkan penjualan yaitu melakukan kegiatan pemasarannya secara sehat dengan melakukan strategi produk, harga, promosi, tempat/distribusi, proses, orang, dan bukti fisik. Penerapan bauran pemasaran yang digunakan oleh CV. Indocipta Karya Gemilang Leilem menggunakan strategi 7P sudah baik.

 

 

Kata Kunci: Penerapan Bauran Pemasaran
THE INFLUENCE OF GREEN MARKETING MIX AND GREEN BRAND AWARENESS TOWARDS CONSUMER PURCHASE INTENTION AT STARBUCKS COFFEE MANADO
Authors: Siwu Gabriela , Tumbuan Willem J. F. A. , Rumokoy Lawren J.
Published: January 2024

This research aims to determine the influence of green marketing mix and green brand awareness towards consumer purchase intention at Starbucks Coffee Manado. This study uses quantitative methods and multiple linear regression to assess the impact of product quality and price on customer satisfaction. The sample for this study was 100 respondents. The sampling technique is the purposive sampling method, and the data collection method is a questionnaire run through Google Form. Testing and data analysis in this study using SPSS 26 software. This study shows that the Green Marketing Mix (X1) has an effect on consumers' purchase intentions, but Green Brand Awareness (X2) has no effect on increasing consumers' purchase intentions. This implies that Starbucks coffee shops in Manado must continue to maintain and improve their green marketing mix and increase the green brand awareness of their brand for consumers, so that a competitive advantage will be achieved.
 
Keywords: green marketing mix, green brand awareness, consumer purchase intention
Analisis Penerapan Tax Planning Pajak Penghasilan Pada PT Bank SulutGo Cabang Utama
Authors: Sinaga Juliana Mega Eriana Br. , Warongan Jessy D.L. , Latjandu Lady D.
Published: January 2024

Perencanaan pajak (tax planning) sangat dibutuhkan perusahaan agar perusahaan membayar pajak dengan efisien melalui tax saving. Penelitian ini bertujuan untuk mengetahui tentang penerapan perencanaan pajak penghasilan badan pada PT. Bank SulutGo Cabang Utama. Metode analisis yang digunakan dalam penelitian skripsi ini adalah penelitian kualitatif. Dari hasil wawancara dengan PT. Bank SulutGo diketahui bahwa pemilihan lokasi perusahaan dan juga bentuk perusahaan sebagai Perseroan Terbatas (PT) tidak mempengaruhi beban pajak serta perusahaan sendiri pada periode 2021 tidak memberikan tunjangan PPh 21 pada karyawan yang membuat tidak adanya pengurangan beban pajak perusahaan namun PT. Bank SulutGo melakukan sumbangan zakat sebesar sembilan miliar delapan puluh enam juta empat ratus tujuh puluh lima ribu delapan ratus dua puluh rupiah dan juga sebagian beban CSR perusahaan bernilai dua miliar enam ratus sembilan puluh delapan juta lima ratus ribu rupiah yang dimana kedua hal ini bebas dari pajak membuat beban pajak perusahaan turun. Total kedua nilai tersebut digunakan dalam tax planning untuk menyesuaikan nilai dari koreksi positif sehingga membuat perbedaan koreksi fiskal sebelum tax planning dan sesudah tax planning menjadi sebesar sebelas miliar tujuh ratus delapan puluh empat juta sembilan ratus tujuh puluh lima ribu delapan ratus sembilan belas rupiah yang dimana hal ini membuat beban pajak perusahaan turun dan menghemat pajak perusahaan sebesar dua miliar lima ratus sembilan puluh dua juta tiga ratus tiga belas ribu dua ratus empat puluh rupiah, peneliti menyarankan beban yang dihematkan bisa digunakan untuk meningkatkan SDM perusahaan agar kualitas operasional perusahaan juga meningkat.
Kata kunci: Perencanaan Pajak, Koreksi Fiskal, Tax planning Bank
PENGARUH KEBERSIHAN, TAMPILAN PRODUK, DAN FASILITAS TERHADAP KEPUTUSAN PEMBELIAN PADA RUMAH MAKAN MIDAL TANTA ROSYE DI WOLOAN TOMOHON
Authors: Mentu Marcela Deryl
Published: January 2024

Penelitian ini bertujuan untuk menganalisa pengaruh Kebersihan, Tampilan Produk, Dan Fasilitas Terhadap Keputusan Pembelian Pada Rumah Makan Midal Tanta Rosye Di Woloan Tomohon. Diukur dari tujuan dan hasil yang ingin dicapai, penelitian ini termasuk penelitian deskriptif dengan metode kuantitatif Kebersihan yang diterapkan di Rumah Makan Midal Tanta Rosye di Woloan Tomohon, baik dalam penyajian makanan maupun lingkungan sekitarnya, dapat menciptakan rasa kenyamanan bagi konsumen. Tampilan produk yang menarik di Rumah Makan Midal Tanta Rosye di Woloan Tomohon berdampak positif pada preferensi dan keputusan konsumen untuk membeli makanan. Fasilitas memiliki pengaruh yang positif dan signifikan terhadap Keputusan Pembelian. Secara simultan diketahui bahwa Kebersihan, Tampilan Produk, dan Fasiltas bersama-sama memiliki pengaruh positif yang signifikan terhadap Keputusan Pembelian pada Rumah Makan Midal Tanta Rosye di Woloan Tomohon.
 
Kata Kunci: kebersihan, tampilan produk, fasilitas, dan keputusan pembelian
ANALISIS DAMPAK IMPLEMENTASI PERATURAN MENTERI KEUANGAN NOMOR 20/PMK.010/2021 TENTANG PPnBM 0% PADA PT. HASJRAT ABADI TOYOTA
Authors: Wuisan Octria Christania Alena , Runtu Treesje , Latjandu Lady D.
Published: January 2024

Pandemi Covid-19 yang terjadi saat ini berdampak buruk pada berbagai bidang, salah satunya adalah bidang perekonomian yang mengalami penurunan. Melemahnya sistem perekonomian ini menyebabkan pendapatan negara dari sektor perpajakan juga mengalami penurunan. Oleh karena itu, pemerintah Indonesia terus berupaya melakukan berbagai cara untuk meningkatkan penerimaan Negara dari sektor perpajakan, diantaranya dengan memberikan insentif pajak PPnBM 0% bagi wajib pajak. Penelitian ini bertujuan untuk mengetahui Dampak Implementasi PMK-20/PMK.010/2021 tentang PPnBM 0% terhadap tingkat penjualan PT. Hasjrat Abadi Toyota. Jenis penelitian ini adalah penelitian kualitatif deskriptif. Hasil penelitian menunjukan bahwa PT. Hasjrat Abadi Toyota telah menerapkan dengan baik segala peraturan yang berlaku didalam PMK-20/PMK.010/2021. Penerapan PMK-20/PMK.010/2021 pada PT. Hasjrat Abadi Toyota memberikan dampak terhadap tingkat penjualan, dimana untuk penjualan mobil jenis Avanza pada bulan April dan Mei mengalami kenaikan yang signifikan yaitu sebesar 38.46% dan 30.79% dari total penjualan selama 5 bulan. Sedangkan untuk penjualan jenis mobil Rush pada bulan Maret, April, dan Mei pada tahun 2021 atau setelah diterapkannya insentif pajak PPnBM 0% mengalami peningkatan yang signifikan yaitu sebesar 34.72%, 29.18%, dan 19,44% dari total penjualan kendaraan jenis Rush selama lima bulan. Hal ini juga menunjukan bahwa tujuan pemerintah untuk meningkatkan daya beli masyarakat disektor industri kendaraan bermotor guna mendorong pertumbuhan ekonomi nasional dimasa pandemi tercapai.
Kata Kunci: PMK 20/PMK.010/2021, PPnBM, Insentif Pajak
A STUDY OF SIMPLE PREDICTORS IN IDENTIFYING BACTERIAL PNEUMONIA IN CHILDREN AGED 6 MONTHS TO 60 MONTHS
Authors: Patwardhan Ajay , Zaveri Sneha Valay , Kumar Brajendra
Published: January 2024

Acute Respiratory Infections (ARI) have quite a high morbidity and mortality in children in developing countries. Our study concluded that hyperreactive airway disease can be differentiated from pneumonia, to a reasonable extent on the basis of clinical features like fever, RR, and simple
investigation like leukocyte count. This may help in rational management with antibiotics, bronchodilators and steroids in these children. This
study offers possibility of redening the current algorithm by incorporating simple predictors that have potential application to the para-medical
personnel. In this context, the feasibility of simplied delivery of aerosolized bronchodilator therapy through a metered dose inhaler and nebulizer
merits exploration. Prevention of over-use of antibiotics and the obvious economic advantage are the major advantages of the rened / re-dened
algorithm used.
A STUDY OF THE ROLE OF DIAZEPAM AND PIRACETAM IN THE MANAGEMENT OF BREATH-HOLDING SPELLS IN CHILDREN
Authors: Patwardhan Ajay , Valay Zaveri Sneha , Kumar Brajendra
Published: January 2024

Breath holding spells are dramatic, involuntary episodes that occur in otherwise healthy children. The role of diazepam or piracetam in the sub
group of children with severe breath holding spells has to be studied. There was a signicant reduction in the frequency of spells in each group
following treatment, but the there was no statistically signicant difference between the groups. The cure rate following treatment was also
comparable among the three groups.Neither diazepam nor piracetam was found to produce a statistically signicant maximum spell-free interval
more than the control group.The mean haemoglobin levels, pre- and post- treatment were comparable in all three groups.From this study, we
conclude that the role of diazepam and piracetam was not found to be signicant as compared to the control group, though there are reports to the
contrary.
A systematic literature review on the rural-urban well-being gap in Europe
Authors: Meloni Cesare , Rocchi Benedetto , Severini Simone
Published: January 2024

A large amount of policy support is spent to foster the development of rural areas in Europe. However, empirical evidence on the well-being differential between rural and urban areas in Europe is scant and incomplete. The present study develops a systematic literature review on this topic, bridging a gap in research as a systematic analysis on the subject has not been developed as far as we know. It uses the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method. The review focuses on definitions of rural-urban most used in the literature, main dimensions of well-being that are analyzed, nature of the data and, finally, evidence that emerged regarding the differences in the various dimensions of well-being between rural and urban populations. The analysis confirms that available evidence is controversial and provides advice on how to develop new and better empirical analyses on this topic.
The impact of COVID-19 on household income and participation in the agri-food value chain: Evidence from Ethiopia
Authors: Squarcina Margherita , Romano Donato
Published: January 2024

The effects of COVID-19 have been highly heterogeneous, crucially depending on household livelihoods. In the context of households reliant on agri-food systems, the extent of these effects significantly depends on their position within the value chain. An assessment of the COVID-19 effects along the agri-food value chain and the identification of pivotal factors influencing these outcomes are key for designing appropriate responses and targeting the population most in need should a crisis akin to COVID-19 emerge in the future. Using a longitudinal dataset from Ethiopia, composed of a pre-COVID baseline and six follow-up phone-based surveys, this paper estimates the COVID-19-induced change in household income and job participation, tracing its evolution throughout seven months after the pandemic onset. Applying both longitudinal and cross-sectional econometric models, we show that the COVID-19 shock reduced both employment and income, with increasingly negative impacts over time. Despite initial resilience in the face of restrictive measures, farming eventually emerged as the most affected segment within the agri-food value chain over the medium term. Access to formal institutions such as insurance and credit services, formal contractual arrangements, and secured land ownership title played a key role in mitigating the likelihood of income loss.
forest-based bioeconomy in Latvia: economic and environmental importance
Authors: Tetere Vineta , Peerlings Jack , Dries Liesbeth
Published: January 2024

The bioeconomy is considered a means to achieving a climate-neutral economy as aimed for in the EU Green Deal. For Latvia, the forest-based bioeconomy has the potential to contribute to this aim. An operational definition of the forest-based bioeconomy is needed to calculate its size. This research aims to provide such a definition and to determine the contribution of the forest-based bioeconomy to GDP, employment, and greenhouse gas emissions. The direct and indirect contribution of the forest-based bioeconomy to economic indicators and climate change is identified using an input-output model. The results of the model show that the forest-based bioeconomy contributes 6.4% to GDP and 6.6% to total employment in Latvia. The contribution to greenhouse gas emissions is 4.9%. Furthermore, if CO2 sequestration is included, the forest-based bioeconomy becomes climate neutral.
Modeling conversion to organic agriculture with an EU-wide farm model
Authors: Kremmydas Dimitrios , Ciaian Pavel , Baldoni Edoardo
Published: January 2024

This paper analyses the impacts of the Farm to Fork strategy (F2F) target of 25% organic farmland by 2030 in the EU using a farm level model. Two approaches are deployed to model conversion to organic agriculture. The first one, the endogenous approach, operates under the assumption that farm conversions to organic production result from assessing the utility difference between organic and conventional production systems. The exogenous approach relies on econometric estimation of the likelihood of farms to convert to organic driven by a combination of monetary and non-monetary drivers. The simulated impacts of the F2F target at the EU level vary depending on the chosen methodology. Gross income changes range from +3.8% under the endogenous approach to -1.3% under the exogenous approach. Both approaches forecast decreased production (-0.5% to -15%) for most crops and animal products upon achieving the organic target.
Bioeconomy and resilience to economic shocks: insights from the COVID-19 pandemic in 2020
Authors: Lasarte-López Jesús , Grassano Nicola , M'barek Robert , Ronzon Tévécia
Published: January 2024

Using the latest release of employment and value added numbers in the bioeconomy sectors, we conducted an analysis on the performance of the EU bioeconomy during the COVID-19 pandemic in 2020. Our findings point to a possibly higher level of resilience of the bioeconomy sectors compared to the overall economy. While employment in the bioeconomy registered a similar (but slightly sharper) decrease to the total EU average (-1.7% vs. -1.4%), the value added fell substantially below average (-0.4% vs. -4.0%). The more contemporary biomass-processing sectors (chemicals and pharmaceuticals, as well as bioelectricity) performed better than the more traditional sectors (such as food or textiles). At the Member State level, we observe a high degree of heterogeneity in sectoral performance. By discussing these estimates alongside previous qualitative insights from the related literature, we emphasize the relevance of the bioeconomy not only for environmental sustainability but also for socioeconomic resilience.
Evaluation of some biomarkers of osteoporosis in women with breast cancer in Al-Najaf Governorate
Authors: AL-Thabhawee Sarah Mohammed Hussein
Published: January 2024

Introduction: Osteoporosis is a systemic disease that affects the mineral density of bones and their structure, which leads to an increase in the softness of the bones. One in three women after the age of fifty worldwide is affected. Both breast cancer and osteoporosis are common diseases in women.  Breast cancer is the most common type of cancer in women, with one in eight women developing breast cancer in their lifetime.Aim of the study       Evaluation of some biomarkers of osteoporosis in women with breast cancer represented by cathepsin K, parathyroid hormone, calcium and vitamin D.

methods: The current study was conducted at the National Cancer Center in Al-Najaf province for the period from 8/15/2022 to 1/20/2023. The study included 60 women with breast cancer and 30 healthy women free of diseases, and it was considered a control group. The ages of patients and healthy people ranged between (30-68) years old, vitamin D, calcium, parathyroid hormone, and cathepsin K were evaluated.

Results: For the indicators of vitamin D and parathyroid hormone (PTH), the results of the statistical analysis did not record any significant difference (p>0.05) between the two groups under study. The results of the statistical analysis showed a significant increase (p<0.0001) in the levels of calcium (Ca) and cathepsin K in infected women compared with healthy women.  Likelihood (p < 0.005) and calcium with a probability level (p < 0.0001).

Conclusion

   Depending on the results reached through the current study, we conclude that there is a high rate of osteoporosis in women with breast cancer. prevalent. Also, an increase in the level of calcium in women with breast cancer, with no difference in parathyroid hormone, which is the most important biomarker for breast cancer diagnosis. An increase in the level of cathepsin K and its negative effect on the level of calcium in women with breast cancer.
Determination of Some Heavy Metals in Tissues of Binni Mesopotamichthys sharpeyi and Water in Al-Dalmaj Marsh/Iraq
Authors: Al-Obeidi Laith , Abbas Al-hamadawi Hussein
Published: January 2024

The study was conducted in Al-Dalmaj marsh, considered one of the most important wetlands at the national and regional level and represents the most critical environment to form a good stock of Binni Mesopotamichthys sharpeyi in Iraq. The study assessed heavy metals in water and M. sharpeyi by detecting accumulation of (Nickel, Cadmium and Lead) in the tissues of gills, liver, and small intestines during the summer and winter seasons 2022-2023.
The study results showed a high concentration of heavy metals in the water during summer compared to winter. Nickel levels ranged (0.19 ±0.627, 0.20 ±0.531) in water for both stations. The highest concentration was (1.339 mg/L) in suspended phase during summer, and ND in dissolved phase in winter, while Cadmium rates were (0.25±0.948, 0.17±0.478) in both stations respectively, the highest concentration was (1.827 mg/L) in suspended phase of station 1 during summer. Both stations ' lead rates were (0.39±1.455, 0.09±1.117). (3.176 mg/L) was the highest concentration in the suspended phase of station 1 during summer, while (0.121 mg/L) was the lowest in the suspended phase in winter.
The results showed a sequence of concentrations of heavy metals in M. sharpeyi organs: Gills > Liver ≥ Small Intestines. The highest concentration rate of Nickel (4.109 & 3.692 mg/g) was recorded in small intestines and liver, respectively, during winter, the lowest rate (3.057 mg/g) was recorded in the gills during summer, the total of sedimentation rate of Ni in the liver and intestines was (3.726 mg/g), whereas (3.114 mg/g) in gills. Cadmium recorded an equal value of (0.957 mg/g) representing the highest percentage in the small intestines for both seasons. The highest concentrations (0.906 mg/g) in liver during summer. The total sedimentation rate of Cd in liver and small intestines was (0.852 mg/g), while (0.738 mg/g) was in gills. Lead recorded a high significant rate reaching to (8.501 mg/g) in gills during summer, followed by (6.115 mg/g) and (5.891 mg/g) in the liver and small intestines, respectively. Generally, lead reached the highest value for all elements assessed in fish at (8.501 mg/g) in the gills during summer, while (5.027 mg/g) was the highest rate in the liver during winter, and (3.709 mg/g) was the lowest rate in small intestines during winter. The total sedimentation rate of Pb in liver and small intestines was (5.185 mg/g), and (6.41 mg/g) was in the gills. Cadmium was recorded above the permissible (0.05 mg/g) limit by FAO [25] in the small intestine and liver, whereas lead exceeded the allowable limits (5 mg/g) by FAO/WHO [26]. Accordingly, the intake of these organs is unsafe for humans, and the registration of these high values poses a risk to the survival of this species as it can cause the death of fish in their environment under certain conditions.
Unraveling the Impact of Short-Chain Fatty Acids on Virulence Genes in Salmonella Typhi: A Gene Expression Profiling Study under SCF-Induced Stress
Authors: M. Abdulridha Fadak , Kudhair Bassam
Published: January 2024

Abstract: Salmonella Typhi is a highly pathogenic bacterium that causes typhoid fever, a serious systematic infectious disease with significant global health implications. Short-chain fatty acids (SCFAs) influence gene expression in other Salmonella strains but their impact on Salmonella Typhi is unclear. This study investigates the impact of specific SCFAs (Sodium Butyrate and Sodium Propionate) on the expression of T3SS-1 virulence-associated genes (hilC, hilD, sipC) and a regulatory gene (ropE) in Salmonella Typhi. Sub-inhibitory concentrations of SCFAs were determined (50mg/ml), allowing analysis of their effects on bacterial behavior without inhibiting growth. Gene expression analysis using RT-qPCR revealed that both Sodium Butyrate and Sodium Propionate significantly downregulated hilC, hilD, and sipC genes, essential for activating virulence factors. However, the ropE gene remained unaffected. These findings suggest that SCFAs play a role in regulating virulence in Salmonella Typhi, consistent with previous research on other Salmonella strains. Understanding SCFAs' influence on Salmonella Typhi virulence could lead to targeted interventions for combatting Salmonella infections and improving public health.