bluuebunny/crossref_metadata_2025 huggingface dataset:
Time-Dependent Odorant Sensitivity Modulation in Insects
Authors: Guo Hao , Smith Dean P.
Published: April 2022

Insects use olfaction to detect ecologically relevant chemicals in their environment. To maintain useful responses over a variety of stimuli, olfactory receptor neurons are desensitized to prolonged or high concentrations of stimuli. Depending on the timescale, the desensitization is classified as short-term, which typically spans a few seconds; or long-term, which spans from minutes to hours. Compared with the well-studied mechanisms of desensitization in vertebrate olfactory neurons, the mechanisms underlying invertebrate olfactory sensitivity regulation remain poorly understood. Recently, using a large-scale functional screen, a conserved critical receptor phosphorylation site has been identified in the model insect Drosophila melanogaster, providing new insight into the molecular basis of desensitization in insects. Here, we summarize the progress in this area and provide perspectives on future directions to determine the molecular mechanisms that orchestrate the desensitization in insect olfaction.
The Potential Role of Regenerative Medicine on the Future Management of Hypoplastic Left Heart Syndrome
Authors: Kelly John M. , Anderson Cole , Breuer Christopher K.
Published: April 2022

The development and translation of regenerative medicine approaches for the treatment of hypoplastic left heart syndrome (HLHS) provides a promising alternative to the current standard of care. We review the strategies that have been pursued to date and those that hold the greatest promise in moving forward. Significant challenges remain. Continued scientific advances and technological breakthroughs will be required if we are to translate this technology to the clinic and move from palliative to curative treatment.
Comment on Zwierz et al. The Long-Term Effects of 12-Week Intranasal Steroid Therapy on Adenoid Size, Its Mucus Coverage and Otitis Media with Effusion: A Cohort Study in Preschool Children. J. Clin. Med. 2022, 11, 507
Authors: Kalfert David
Published: April 2022

I read with great interest the article entitled “The Long-Term Effects of 12-Week Intranasal Steroid Therapy on Adenoid Size, Its Mucus Coverage and Otitis Media with Effusion: A Cohort Study in Preschool Children” by Zwierz et al. [...]
Sleep Disorders in Adults with Prader–Willi Syndrome: Review of the Literature and Clinical Recommendations Based on the Experience of the French Reference Centre
Authors: Dodet Pauline , Sanapo Federica , Leu-Semenescu Smaranda , Coupaye Muriel , Bellicha Alice , Arnulf Isabelle , Poitou Christine , Redolfi Stefania
Published: April 2022

Prader–Willi syndrome (PWS) is a rare, genetic, multisymptomatic, neurodevelopmental disease commonly associated with sleep alterations, including sleep-disordered breathing and central disorders of hypersomnolence. Excessive daytime sleepiness represents the main manifestation that should be addressed by eliciting the detrimental effects on quality of life and neurocognitive function from the patients’ caregivers. Patients with PWS have impaired ventilatory control and altered pulmonary mechanics caused by hypotonia, respiratory muscle weakness, scoliosis and obesity. Consequently, respiratory abnormalities are frequent and, in most cases, severe, particularly during sleep. Adults with PWS frequently suffer from sleep apnoea syndrome, sleep hypoxemia and sleep hypoventilation. When excessive daytime sleepiness persists after adequate control of sleep-disordered breathing, a sleep study on ventilatory treatment, followed by an objective measurement of excessive daytime sleepiness, is recommended. These tests frequently identify central disorders of hypersomnolence, including narcolepsy, central hypersomnia or a borderline hypersomnolent phenotype. The use of wake-enhancing drugs (modafinil, pitolisant) is discussed in multidisciplinary expert centres for these kinds of cases to ensure the right balance between the benefits on quality of life and the risk of psychological and cardiovascular side effects.
Insomnia Symptoms, Sleep Hygiene, Mental Health, and Academic Performance in Spanish University Students: A Cross-Sectional Study
Authors: Carrión-Pantoja Sara , Prados Germán , Chouchou Florian , Holguín Martha , Mendoza-Vinces Ángela , Expósito-Ruiz Manuela , Fernández-Puerta Laura
Published: April 2022

Background: Insomnia has been associated with decreased academic performance and unhealthy behaviors in university students. Although many studies have analyzed sleep phenomenology among this population, only few have focused on insomnia and its related variables. In addition, such studies do not always include a clinical interview or a specific and validated instrument for measuring insomnia. This study aimed to explore the prevalence of insomnia symptoms and the relationship between insomnia and health habits, mental health, and academic performance in a large university student sample. Methods: Five hundred and eighty-two students were recruited from the University of Granada, Spain. Data were collected through an online survey with questions on sociodemographic and academic data and health habits as well as the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Sleep Hygiene Index, and Sleepiness, Depression, Anxiety, and Stress Scales. A multiple regression analysis explored the relationship between academic performance, health habits, mood state, and insomnia symptoms. Results: The prevalence of students with symptoms of insomnia was high (39.7%). A multiple logistic regression analysis revealed that depression, sleep hygiene, stress and anxiety were significant predictors of insomnia symptoms. Multivariate analyses revealed that subjective insomnia symptoms, sleep efficiency, and depression were significantly correlated with academic performance in a dependent way. Conclusions: In university students, anxiety, stress, and poor sleep hygiene are risk factors for insomnia, which plays an important role in academic performance. Promoting sleep and mental health could be a potentially effective way to improve their academic performance.
Impact of Operator Medical Specialty on Endotracheal Intubation Rates in Prehospital Emergency Medicine—A Retrospective Cohort Study
Authors: Fehlmann Christophe A. , Chan Michèle , Betend Romain , Novotny-Court Fiona , Suppan Mélanie , Savoldelli Georges L. , Suppan Laurent
Published: April 2022

Prehospital endotracheal intubation (ETI) can be challenging, and the risk of complications is higher than in the operating room. The goal of this study was to compare prehospital ETI rates between anaesthesiologists and non-anaesthesiologists. This retrospective cohort study compared prehospital interventions performed by either physicians from the anaesthesiology department (ADP) or physicians from another department (NADP, for non-anaesthesiology department physicians). The primary outcome was the prehospital ETI rate. Overall, 42,190 interventions were included in the analysis, of whom 68.5% were performed by NADP. Intubation was attempted on 2797 (6.6%) patients, without any difference between NADPs and ADPs (6.5 versus 6.7%, p = 0.555). However, ADPs were more likely to proceed to an intubation when patients were not in cardiac arrest (3.4 versus 3.0%, p = 0.026), whereas no difference was found regarding cardiac arrest patients (65.2 versus 67.7%, p = 0.243) (p for homogeneity = 0.005). In a prehospital physician-staffed emergency medical service, overall ETI rates did not depend on the frontline operator’s medical specialty background. ADPs were, however, more likely to proceed with ETI than NADPs when patients were not in cardiac arrest. Further studies should help to understand the reasons for this difference.
Effect of Sulodexide on Circulating Blood Cells in Patients with Mild COVID-19
Authors: Melkumyants Arthur , Buryachkovskaya Lyudmila , Lomakin Nikita , Antonova Olga , Docenko Julia , Ermishkin Vladimir , Serebruany Victor
Published: April 2022

Background. Despite the fact that COVID-19 usually manifests with severe pneumonia, there is a growing body of evidence that life-threatening multiorgan damage is caused by vascular and hemostatic abnormalities. Since there is no established therapy, assessing antithrombotics is indeed important. Sulodexide, a compound derived from porcine intestinal mucosa is a mixture of fast-moving heparin fraction (80%) and dermatan sulfate (20%), is approved in Europe and currently in trials for COVID-19 indication. Methods. This single-center, prospective, observational study included 28 patients with mild COVID-19 hospitalized in the Central Clinical Hospital of the Presidential Administration of the Russian Federation. Patients in the control group (n = 14) were treated using routine therapy according to current guidelines, while patients in the experimental group (n = 14) had the routine treatment supplemented with daily intravenous injections of sulodexide in 600-unit doses. Scanning electron microscopy was utilized to examine the blood specimens derived from the cubital vein at admission and at 10 days after hospitalization, which was approximately the average duration of patients’ treatment in the hospital (11.6 ± 0.4 days). Results. Sulodexide significantly (by 40%) diminished the score of circulating endothelial cells, potentially indicating its antiviral endothelium-protective properties. It also prevented the extra activation of the platelets and the formation of erythrocytic sludges. Among patients in the control group, the share of activated platelets rose from 37 ± 5% to 45 ± 6% (p = 0.04) over the course of the study period, whereas among patients in the experimental group, the share of activated platelets remained practically unchanged (43 ± 6% vs. 38 ± 4%, p = 0.22). The score of erythrocytic sludges in the control group remained practically the same (4.8 ± 1.1 at admission vs. 3.9 ± 0.9 after 10 days, p = 0.67), whereas in the experimental group, it significantly decreased (from 5.7 ± 1.7 to 2.4 ± 0.9, p = 0.03). Conclusions. Sulodexide is able to defend endothelium, normalize blood, and, seemingly, prevent thrombosis. Therefore, it may be considered as a promising and effective agent for the treatment of patients with mild COVID-19. Broader randomized trials are needed to assess whether the observed findings will transform into sustained long-term clinical benefit.
Implant-Supported Prosthesis Is a Viable Treatment Alternative for American Society of Anesthesiology Physical Status 3 Individuals—A Retrospective Cohort Study
Authors: Masri Daya , Masri-Iraqi Hiba , Naishlos Sarit , Weinberg Evgeny , Reiser Vadim , Chaushu Liat
Published: April 2022

Background: Within medicine, it is common to use risk prediction tools towards clinical decision making. One of the most widely accepted assessment tools is the American Society of Anesthesiologists Physical Status (ASA PS) classification. Oral and maxillofacial procedures performed in an ambulatory setting would be considered low risk for the procedure itself. However, little is known concerning the impact of ASA PS on surgical outcomes. The aim of the present research was to evaluate the effect of ASA PS classification on early implant failure (EIF). Methods: Retrospective cohort study based on dental records. All treatments were performed by experienced oral and maxillofacial surgeons and experienced prosthodontists. Inclusion criteria: ASA physical status 1,2,3, consecutive individuals. Variables included the following: age, gender, implant location, implant length, implant width, smoking, and early implant failure. Results: Univariate tests at the patient level showed no statistically difference between the different classifications of ASA PS (1,2,3). Multivariate model using logistic regression at individual level showed that two factors were found to be associated with an increased risk for EIF—augmented bone and implant brand. Conclusions: ASA PS 3 is not a contraindication for implant-supported prostheses. EIF in ASA PS 3 is not significantly different from ASA PS 1,2. In contrast, factors such as bone augmentation and implant brand might be significant risk factors for EIF, regardless of ASA PS.
Embolic Protection with the TriGuard 3 System in Nonagenarian Patients Undergoing Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis
Authors: Lind Alexander , Jánosi Rolf Alexander , Totzeck Matthias , Ruhparwar Arjang , Rassaf Tienush , Al-Rashid Fadi
Published: April 2022

Background: Transcatheter aortic valve replacement (TAVR) improves the survival and life quality of nonagenarian patients with aortic stenosis. Stroke remains one of the most worrisome complications following TAVR. Cerebral embolic protection devices (CEPDs) may reduce neurological complications after TAVR. This study evaluated the safety and efficacy of CEPDs during TAVR in nonagenarian patients. Methods: Between January 2018 and October 2021, 869 patients underwent transfemoral TAVR (TF-TAVR) at our center. Of these, 51 (5.9%) patients were older than ninety years. In 33 consecutive nonagenarian patients, TF-TAVR was implanted without CEPDs using balloon-expandable valves (BEVs) and self-expandable valves (SEVs). Eighteen consecutive nonagenarians underwent TF-TAVR using a CEPD (CP group). Follow up period was in-hospital or 30 days after the procedure, respectively. Results: Minor access site complications occurred in two patients (3.9%) and were not CEPD-associated. Postinterventional delirium occurred in nine patients (17.6%). Periprocedural minor non-disabling stroke and delirium occurred in ten patients (19.6%). Periprocedural major fatal stroke occurred in two patients in the BEV group (3.9%). Two patients in the BEV group died due to postinterventional pneumonia with sepsis. The mortality rate was 7.8%. The results did not differ between the groups. Conclusions: Age alone is no longer a contraindication for TAVR. CEPD using the Triguard 3 system in nonagenarian TAVR patients was feasible and safe and did not increase access site complications.
Patellar Tendinopathy—Does Injection Therapy Have a Role? A Systematic Review of Randomised Control Trials
Authors: Nuhmani Shibili , Ahsan Mohammad , Bari Mohd Arshad , Malhotra Deepak , Al Muslem Wafa Hashem , Alsaadi Saad Mohammed , Muaidi Qassim Ibrahim
Published: April 2022

Injection treatment is one of the most widely used methods for the conservative management of patellar tendinopathy. The objective of this systematic review was to synthesise data from randomised control trails on the effectiveness of various injections used in the management of patellar tendinopathy. An electronic search was conducted in the Web of Science, Scopus, PubMed, and SPORTDiscus databases. To be included in the current systematic review, the study had to be an RCT conducted on human participants that investigated the effect of at least one injection treatment on the management of patellar tendinopathy. Selected studies were required to report either patient-reported outcomes or biological and clinical markers of the tendon healing. The methodological quality of the studies was appraised using the revised Cochrane risk of bias tool for RCTs (RoB 2.0). Nine RCTs on seven types of injections were included in this review, with an overall positive outcome. Pain intensity was measured in all the studies. The VISA P score was the most used outcome measure (n = 8). A wide variety of interventions were compared with injection therapy, including eccentric training, extracorporeal shockwave, and arthroscopy. It can be concluded that the injection treatments can produce promising results in the management of patellar tendinopathy. However, because of the limited number of studies and the disparities in the study populations and protocols, it is not possible to make a firm conclusion on the efficacy of these injection methods, and these results should be inferred with care.
Machine Learning for Early Parkinson’s Disease Identification within SWEDD Group Using Clinical and DaTSCAN SPECT Imaging Features
Authors: Khachnaoui Hajer , Khlifa Nawres , Mabrouk Rostom
Published: April 2022

Early Parkinson’s Disease (PD) diagnosis is a critical challenge in the treatment process. Meeting this challenge allows appropriate planning for patients. However, Scan Without Evidence of Dopaminergic Deficit (SWEDD) is a heterogeneous group of PD patients and Healthy Controls (HC) in clinical and imaging features. The application of diagnostic tools based on Machine Learning (ML) comes into play here as they are capable of distinguishing between HC subjects and PD patients within an SWEDD group. In the present study, three ML algorithms were used to separate PD patients from HC within an SWEDD group. Data of 548 subjects were firstly analyzed by Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA) techniques. Using the best reduction technique result, we built the following clustering models: Density-Based Spatial (DBSCAN), K-means and Hierarchical Clustering. According to our findings, LDA performs better than PCA; therefore, LDA was used as input for the clustering models. The different models’ performances were assessed by comparing the clustering algorithms outcomes with the ground truth after a follow-up. Hierarchical Clustering surpassed DBSCAN and K-means algorithms by 64%, 78.13% and 38.89% in terms of accuracy, sensitivity and specificity. The proposed method demonstrated the suitability of ML models to distinguish PD patients from HC subjects within an SWEDD group.
A Comparative Review on Applications of Different Sensors for Sign Language Recognition
Authors: Amin Muhammad Saad , Rizvi Syed Tahir Hussain , Hossain Md. Murad
Published: April 2022

Sign language recognition is challenging due to the lack of communication between normal and affected people. Many social and physiological impacts are created due to speaking or hearing disability. A lot of different dimensional techniques have been proposed previously to overcome this gap. A sensor-based smart glove for sign language recognition (SLR) proved helpful to generate data based on various hand movements related to specific signs. A detailed comparative review of all types of available techniques and sensors used for sign language recognition was presented in this article. The focus of this paper was to explore emerging trends and strategies for sign language recognition and to point out deficiencies in existing systems. This paper will act as a guide for other researchers to understand all materials and techniques like flex resistive sensor-based, vision sensor-based, or hybrid system-based technologies used for sign language until now.
Prometastatic CXCR4 and Histone Methyltransferase EZH2 Are Upregulated in SMARCB1/INI1-Deficient and TP53-Mutated Poorly Differentiated Chordoma
Authors: Joldoshova Albina , Elzamly Shaimaa , Brown Robert , Buryanek Jamie
Published: April 2022

Background: Chordoma is a rare tumor most commonly arising in the sacrococcygeal region from notochord remnants. Usually, these tumors are locally invasive and recurrent, and they have a 5–43% ability to metastasize. A newly-described aggressive variant called poorly differentiated chordoma is different from conventional chordoma in that it does not have the well-differentiated histologic appearance of conventional chordoma and also exhibits the loss of SMARCB1/INI1. Herein, we describe a case of poorly differentiated chordoma with SMARCB1/INI1 loss, a concurrent TP53 mutation, and Rb1 loss. Methods: The patient is a middle-aged man with a history of previously resected sacrococcygeal chordoma, who was found to have new hepatic, lung, and adrenal lesions. Results: Biopsy of the liver lesion showed sheets of malignant epithelioid cells with vacuolated cytoplasm, areas of necrosis, and up to five mitoses in one high-power field. No physaliferous cytologic features or matrix material was seen. After reviewing an extensive panel of immunohistochemical markers, the origin of the metastatic tumor could not be determined; the tumor was only positive for Cam5.2, EMA, and CD56. Brachyury was performed due to the patient’s previous history and was positive. Genomic testing showed a SMARCB1 mutation, TP53 mutation, and RB1 loss. Additional markers were performed, and the tumor showed a Ki-67 proliferation index of approximately 80%, mutant p53 protein, loss of INI1, and strong expression of both the histone methyl transferase EZH2 and the chemokine receptor CXCR4. Conclusions: Poorly differentiated chordoma is a highly aggressive variant of chordoma with few cases reported. This case of SMARCB1/INI-deficient, poorly differentiated chordoma also showed a concurrent TP53 mutation and loss of RB1, which resulted in malignant transformation with upregulation of both prometastatic CXCR4 and the histone methyltransferase EZH2, causing aggressive behavior and metastasis.
Sustainable Cross-Linkers for the Synthesis of Cellulose-Based Aerogels: Research and Application
Authors: Paulauskiene Tatjana , Teresiute Audrone , Uebe Jochen , Tadzijevas Arturas
Published: April 2022

Cellulose aerogels with polyester resin as cross-linkers have attracted much attention. This study describes the route to produce a fully bio-based aerogel with high added value from waste paper and starch, cellulose acetate and starch–cellulose acetate mixture as cross-linkers for oil adsorption, instead of the environmentally harmful polyester resin. The manufacturing process is simple, sustainable and cost-efficient, without releasing harmful by-products into the environment. The effects of different cross-linkers on the oil adsorption, dynamic oil retention, reusability and morphology of the aerogels were studied in detail. Experimental results show that these environmentally friendly recycled aerogels have a very low density, i.e., —0.0110–0.0209 g cm−3, and highly porous structures, with a porosity of 96.74–99.18%. The synthesized hydrophobic aerogels showed contact angles of ∼124–129°. The compression moduli are lower than that of an aerogel with polyester as a cross-linker, but the compression modulus of the mixture of starch and cellulose acetate especially shows a higher value than expected. The sorption capacity of the aerogels with bio-based cross-linkers was significantly increased compared to the aerogels with polyester; it is now up to 56 times their own weight. The aerogels also have good oil-retention properties.
A Review of the Role of the Oceanic Rossby Waves in Climate Variability
Authors: Pinault Jean-Louis
Published: April 2022

In this paper, the role of oceanic Rossby waves in climate variability is reviewed, as well as their dynamics in tropical oceans and at mid-latitudes. For tropical oceans, both the interactions between equatorial Rossby and Kelvin waves, and off-equatorial Rossby waves are privileged. The difference in the size of the basins induces disparities both in the forcing modes and in the dynamics of the tropical waves, which form a single quasi-stationary wave system. For Rossby waves at mid-latitudes, a wide range of periods is considered, varying from a few days to several million years when very-long-period Rossby waves winding around the subtropical gyres are hypothesized. This review focuses on the resonant forcing of Rossby waves that seems ubiquitous: the quasi-geostrophic adjustment of the oceans favors natural periods close to the forcing period, while those far from it are damped because of friction. Prospective work concentrates on the resonant forcing of dynamical systems in subharmonic modes. According to this new concept, the development of ENSO depends on its date of occurrence. Opportunities arise to shed new light on open issues such as the Middle Pleistocene transition.
Controls of Submarine Canyons Connected to Shore during the LGM Sea-Level Rise: Examples from Taiwan
Authors: Chiang Cheng-Shing , Yu Ho-Shing
Published: April 2022

During the Last Glacial Maximum (LGM) (~20,000 years ago), the sea level was lower than that during the present day by 120 m and the heads of most submarine canyons were close or connected to the coastline or shore, with enhanced terrestrial sediment input due to direct connections with river mouths. This was followed by a relative sea-level rise of 120 m and the migration of coastlines landward. As a result, the heads of some paleo-submarine canyons were no longer near river mouths or connected to the shore. Such canyons became inactive due to the lack of terrestrial sediment input. Only 4% of the world’s submarine canyons reach the coastline and remain active today. Among 13 submarine canyons off the shore of Taiwan, we identified seven (n = 7, 54%) that remain connected to the shore and are active during the present-day highstand. The purpose of this study is to determine the key controls of canyon heads that remain connected to the shore with terrestrial sediment input during the Holocene sea-level rise. As a result of high uplift rates, narrow coastal range, steep gradients, frequent earthquakes, and typhoon development in the Taiwan mountain belt, Taiwan has the highest-yield river and sediment supply. This has led to the transportation of large volumes of sediment to the surrounding deep seas. Narrow steep shelves and large sediment volumes associated with small mountain rivers are the main controls involved in the development of shore-connected canyons on the active Taiwan margin. Shore-connected canyons are present in greater numbers in the major earthquake zone on the eastern Taiwan margin. Frequent earthquake events are another significant factor in the occurrence of shore-connected canyons in the Taiwan region.
Assessment of Yeasts as Potential Probiotics: A Review of Gastrointestinal Tract Conditions and Investigation Methods
Authors: Alkalbani Nadia S. , Osaili Tareq M. , Al-Nabulsi Anas A. , Olaimat Amin N. , Liu Shao-Quan , Shah Nagendra P. , Apostolopoulos Vasso , Ayyash Mutamed M.
Published: April 2022

Probiotics are microorganisms (including bacteria, yeasts and moulds) that confer various health benefits to the host, when consumed in sufficient amounts. Food products containing probiotics, called functional foods, have several health-promoting and therapeutic benefits. The significant role of yeasts in producing functional foods with promoted health benefits is well documented. Hence, there is considerable interest in isolating new yeasts as potential probiotics. Survival in the gastrointestinal tract (GIT), salt tolerance and adherence to epithelial cells are preconditions to classify such microorganisms as probiotics. Clear understanding of how yeasts can overcome GIT and salt stresses and the conditions that support yeasts to grow under such conditions is paramount for identifying, characterising and selecting probiotic yeast strains. This study elaborated the adaptations and mechanisms underlying the survival of probiotic yeasts under GIT and salt stresses. This study also discussed the capability of yeasts to adhere to epithelial cells (hydrophobicity and autoaggregation) and shed light on in vitro methods used to assess the probiotic characteristics of newly isolated yeasts.
Effect of Fungal Endophyte Epichloë bromicola Infection on Cd Tolerance in Wild Barley (Hordeum brevisubulatum)
Authors: Zhai Yurun , Chen Zhenjiang , Malik Kamran , Wei Xuekai , Li Chunjie
Published: April 2022

Hydroponic Hordeum brevisubulatum (wild barley) was used as material in the greenhouse to study the effects of endophyte infection on plant growth, Cd absorption and transport, subcellular distribution, and Cd chemical forms under CdCl2 stress. Endophytic fungi respond positively to chlorophyll content and photosynthetic efficiency under Cd stress. The order of Cd absorption in different parts of the plant was: roots > stems > leaves. Endophyte infection increased the plant’s absorption and transport of Cd while causing a significant difference in the stem, which was associated with the distribution density of endophyte hyphae. The proportion of organelle Cd in endophyte-infected wild barley was significantly higher, which facilitated more Cd transport to aboveground. Cd stress showed a slight effect on the chemical forms of Cd in leaves. The proportion of phosphate, oxalate, and residual Cd increased in the stem. Cd existed in the form of inorganic salt, organic acid, pectin, and protein in roots. Endophyte infection reduced the Cd content of the more toxic chemical forms to protect the normal progress of plant physiological functions. Therefore, the isolation of cell walls and vacuoles is a key mechanism for plant Cd tolerance and detoxification. As endophyte infections have more ability to absorb Cd in plants, H. brevisubulatum–Epichloë bromicola symbionts can improve heavy metal contaminated soil and water.
Trichoderma: An Eco-Friendly Source of Nanomaterials for Sustainable Agroecosystems
Authors: Alghuthaymi Mousa A. , Abd-Elsalam Kamel A. , AboDalam Hussien M. , Ahmed Farah K. , Ravichandran Mythili , Kalia Anu , Rai Mahendra
Published: April 2022

Traditional nanoparticle (NP) synthesis methods are expensive and generate hazardous products. It is essential to limit the risk of toxicity in the environment from the chemicals as high temperature and pressure is employed in chemical and physical procedures. One of the green strategies used for sustainable manufacturing is microbial nanoparticle synthesis, which connects microbiology with nanotechnology. Employing biocontrol agents Trichoderma and Hypocrea (Teleomorphs), an ecofriendly and rapid technique of nanoparticle biosynthesis has been reported in several studies which may potentially overcome the constraints of the chemical and physical methods of nanoparticle biosynthesis. The emphasis of this review is on the mycosynthesis of several metal nanoparticles from Trichoderma species for use in agri-food applications. The fungal-cell or cell-extract-derived NPs (mycogenic NPs) can be applied as nanofertilizers, nanofungicides, plant growth stimulators, nano-coatings, and so on. Further, Trichoderma-mediated NPs have also been utilized in environmental remediation approaches such as pollutant removal and the detection of pollutants, including heavy metals contaminants. The plausible benefits and pitfalls associated with the development of useful products and approaches to trichogenic NPs are also discussed.
Mycobacterium tuberculosis and Pulmonary Rehabilitation: From Novel Pharmacotherapeutic Approaches to Management of Post-Tuberculosis Sequelae
Authors: Meca Andreea-Daniela , Mititelu-Tarțău Liliana , Bogdan Maria , Dijmarescu Lorena Anda , Pelin Ana-Maria , Foia Liliana Georgeta
Published: April 2022

Tuberculosis (TB) is still a worldwide public health burden, as more than 1.3 million deaths are expected to be reported in 2021. Even though almost 20 million patients have completed specific anti-TB treatment and survived in 2020, little information is known regarding their pulmonary sequelae, quality of life, and their need to follow rehabilitation services as researchers shifted towards proper diagnosis and treatment rather than analyzing post-disease development. Understanding the underlying immunologic and pathogenic mechanisms during mycobacterial infection, which have been incompletely elucidated until now, and the development of novel anti-TB agents could lead to the proper application of rehabilitation care, as TB sequelae result from interaction between the host and Mycobacterium tuberculosis. This review addresses the importance of host immune responses in TB and novel potential anti-TB drugs’ mechanisms, as well as the assessment of risk factors for post-TB disease and usefulness of guidance and optimization of pulmonary rehabilitation. The use of rehabilitation programs for patients who successfully completed anti-tuberculotic treatment represents a potent multifaceted measure in preventing the increase of mortality rates, as researchers conclude that a patient with a TB diagnosis, even when properly completing pharmacotherapy, is threatened by a potential life loss of 4 years, in comparison to healthy individuals. Dissemination of pulmonary rehabilitation services and constant actualization of protocols could strengthen management of post-TB disease among under-resourced individuals.
The Use of Allogeneic Hematopoietic Stem Cell Transplantation in Primary Myelofibrosis
Authors: Wolfe Heather R. , Horwitz Mitchell E. , Rein Lindsay A. M.
Published: April 2022

Primary myelofibrosis (PMF) is a BCR-ABL1 negative myeloproliferative neoplasm characterized by clonal proliferation of myeloid cells. This leads to reactive bone marrow fibrosis, ultimately resulting in progressive marrow failure, hepatosplenomegaly, and extramedullary hematopoiesis. PMF is considered the most aggressive of the BCR-ABL1 negative myeloproliferative neoplasms with the least favorable prognosis. Constitutional symptoms are common, which can impact an individual’s quality of life and leukemic transformation remains an important cause of death in PMF patients. The development of the Janus kinase 2 (JAK2) inhibitors have provided a good option for management of PMF-related symptoms. Unfortunately, these agents have not been shown to improve overall survival or significantly alter the course of disease. Allogenic hematopoietic stem cell transplantation (allo-HSCT) remains the only curative treatment option in PMF. However, allo-HSCT is associated with significant treatment-related morbidity and mortality and has historically been reserved for younger, high-risk patients. This review examines patient, disease, and transplant-specific factors which may impact transplant-related outcomes in PMF. Through the vast improvements in donor selection, conditioning regimens, and post-transplant care, allo-HSCT may provide a safe and effective curative option for a broader range of PMF patients in the future.
Rhythm Control Better Prevents Dementia than Rate Control Strategies in Patients with Atrial Fibrillation—A Nationwide Cohort Study
Authors: Lin Jiunn-Cherng , Li Cheng-Hung , Chen Yun-Yu , Weng Chi-Jen , Chien Yu-Shan , Wu Shang-Ju , Lo Chu-Pin , Tien Hui-Chun , Lin Ching-Heng , Huang Jin-Long , Lin Yenn-Jiang , Hsieh Yu-Cheng , Chen Shih-Ann
Published: April 2022

Background: Atrial fibrillation (AF) increases the risk of dementia. Whether the pharmacological rhythm control of AF can reduce the risk of dementia compared to the rate control strategy remains unclear. We hypothesize that the rhythm control strategy is better than the rate control strategy in preventing dementia. Methods: AF patients aged ≥65 years were identified from the Taiwan National Health Insurance Database. Patients receiving anti-arrhythmic drugs at a cumulative defined daily dose (cDDD) of >30 within the first year of enrollment constituted the rhythm control group. Patients who used rate control medications for a cDDD of >30 constituted the rate control group. A multivariate Cox hazards regression model was used to determine the hazard ratio (HR) for dementia. Results: A total of 3382 AF patients (698 in the rhythm control group; 2684 in the rate control group) were analyzed. During a 4.86 ± 3.38 year follow-up period, 414 dementia events occurred. The rhythm control group had a lower rate of dementia than the rate control group (adjust HR: 0.75, p = 0.031). The rhythm control strategy reduced the risk of dementia particularly in those receiving aspirin (p = 0.03). Conclusions: In patients with AF, pharmacological rhythm control was associated with a lower risk of dementia than rate control over a long-term follow-up period, particularly in patients receiving aspirin treatment.
Point-of-Care Ultrasound (POCUS) for Dialysis Patients: A Step Forward
Authors: Tsangalis Georgios , Loizon Valerie
Published: April 2022

Point-of-care ultrasound (POCUS) refers to the use of portable ultrasound systems by clinicians at a patient’s bedside for diagnostic and therapeutic purposes. It is not a substitute but rather a complement to clinical examination, and contrary to the classic ultrasound examination performed by radiologists, POCUS is not a detailed morphologic examination but focuses on answering specific clinical questions in an effort to reduce time to diagnosis and treatment, improve patient safety and decrease complication rates. In this article, we present the POCUS in hemodialysis units for and beyond vascular-access purposes, arguing that its implementation will help the practicing nephrologist who is treating hemodialysis patients on a daily basis to rapidly and efficiently answer several clinical questions that are common to dialysis patients, such as vascular-access assessment and cannulation, and assessment of volume status. POCUS aims to answer specific clinical questions, so a question-answer format is used. This review is divided in two parts. In the first part we will answer specific clinical questions exclusively concerning vascular access. The second part is dedicated to the use of POCUS for the assessment of volume status and dry-weight determination.
Understanding the Impact of Land Supply Structure on Low Consumption: Empirical Evidence from China
Authors: Dai Yating , Cheng Jian , Zhu Daolin
Published: April 2022

In studies of low consumption in China, there is a lack of consideration of land policy, which may be an important factor contributing to the industrial structure, thus impacting consumption. This paper explores the relationship between local governments’ distorted land supply strategies and final consumption and its mechanism of action based on panel data for 31 provinces in China from 2002 to 2017, using a fixed-effects panel model and a mediating-effects model. The results show that (1) the ratio of industrial land supply area to the land supply area of commercial and residential significantly suppresses the final consumption rate, and the results remain significant after robustness tests; (2) the effect of land supply structure on final consumption is related to the development strategy adopted by local governments and the urban–rural inequity, thus showing heterogeneity, with regions with high economic growth and large urban–rural income gaps further contributing to the suppression of consumption rates; (3) the intermediation effect suggests that the structure of land supply affects consumption through the industrial structure. As land supply favors the development of industrial enterprises, it increases the ratio of gross capital formation to GDP and can have a crowding-out effect on the income of the household sector, thus reducing the rate of final consumption. Under the Chinese decentralization system, in order to achieve regional economic development, local governments intervene in the allocation of land resources among different industries through differentiated land supply strategies, resulting in an industrial structure dominated by the secondary industry, which has an important impact on consumption. Therefore, the reform of the land supply structure should be accelerated to restrain the excessive intervention of local governments in the land supply structure and promote the transformation of the economic development model to enhance consumption.
Limited Decentralization: Understand China’s Land System from the Perspective of Central-Local Relation
Authors: Lu Shenghua , Wang Hui
Published: April 2022

Central-local relation is a critical but overlooked perspective for understanding China’s land system. During the last decades, the central government has decentralized considerable autonomy of land development to local governments to encourage the latter to adopt their advantages in local information for economic growth. However, the local government pursues more development-oriented goals, leading land to be an endowment for jurisdiction competition, fiscal revenue maximization, and officials’ career advancement at the local level. The discretion of local government, however, is constrained by the central authority. Land quotas, land approval, and, perhaps most importantly, nomenklatura, all of which are controlled by the central government, undermine the credibility and irreversibility of decentralization. We call such a central-local relation limited decentralization, a framework that could be applied to explain a range of land issues such as farmland protection and real estate regulation. Although we believe the central government is the principal determinant of the degree of decentralization, we also acknowledge that the initiative of local governments is essential. The interactions between central and local governments result in rights definition, power distribution, and, consequently, land use policy change over time.
Analysis of the Forest Landscape and Its Transformations through Phytotoponyms: A Case Study in Calabria (Southern Italy)
Authors: Spampinato Giovanni , Crisarà Rita , Cameriere Piergiorgio , Cano-Ortiz Ana , Musarella Carmelo Maria
Published: April 2022

Place names, or toponyms, provide a useful geographical reference system; they can help analyse past landscapes, recover history and understand changes. Among place names, plant place names (phytotoponyms) can be used to analyse the current and past distribution of plants and plant communities and to highlight changes in land use due to human impacts and climate change. We assessed the feasibility of using place names related to species and forest ecosystems to evaluate changes that have affected the forest landscape. As a case study, we considered Calabria, a region in southern Italy rich in toponymic studies. We used the official topographic maps of Calabria, at scales of 1:25,000 and 1: 10,000, and literature data on Calabrian toponymy. To interpret toponyms related to plants and avoid errors, we performed a joint linguistic and naturalistic analysis. A total of 1609 phytotoponyms were identified relating to 45 forest species (28 trees and 17 shrubs) and 399 place names generically related to woods and forests. The most frequent plants associated with place names were Castanea sativa (8.3% of all plant place names), Quercus pubescens s.l. (7.2%), Salix sp. pl. (6.9%) and Quercus frainetto (5.6%). All the phytotoponyms were georeferenced and mapped in a GIS. Phytotoponym distribution maps were compared with current Calabrian forest vegetation, using digital orthophotos, land use maps and literature data. A close correspondence between phytotoponyms and forest vegetation for the mountain belt was identified. In contrast, in the basal belt, we found poor correspondence between phytotoponyms and current forest vegetation, especially for wet forests, that can be accounted for by the severe changes in the landscape due to the agricultural and urban transformations that have occurred. The spread of phytotoponyms concerning species linked to forest degradation, such as Spartium junceum, emphasises the ancient anthropic impacts on forests. Our study shows that phytotoponyms are an important tool for analysing changes in vegetation over time. They make it possible to reconstruct changes in the landscape and the intended use of the territory and provide useful information on the restoration of forest ecosystems.
A Systematic Review of EU-Funded Innovative Agri-Food Projects: Potential for Transfer between Territories
Authors: Ibáñez-Jiménez Álvaro , Jiménez-Olivencia Yolanda , Mesa-Pedrazas Ángela , Porcel-Rodríguez Laura , Zimmerer Karl
Published: April 2022

This article presents a systematic review of innovative projects funded by EU Rural Development Programs that were designed and implemented in rural areas of the European Union to facilitate the territorialized production of foodstuffs and their sale through alternative networks. On the basis of the results obtained in this review, we designed a model for the transfer of knowledge to the local community in the Alpujarra Granadina (Granada, Spain) within the framework of the LifeWatch project. This study uses two consecutive methodological approaches. We began by developing a protocol for the systematic search and analysis of successful rural development projects carried out in the European Union between 2007 and 2020. After that, we created a model for the transfer of results using a participative methodological approach. The results of our analysis of the group of projects selected for review show that the main innovations were made in different aspects of the product, process, sales and distribution. These innovative ideas were implemented by rural communities with a high degree of collective initiative and intelligence and could potentially be replicated in other areas. The sample analyzed contains a wide array of novel, alternative formulas, which are transversal to the projects, so provide significant contents that could be used to activate a space for participation and debate, which could itself become fertile ground for the creation of new projects. In conclusion, this study provides the stakeholders in rural areas, in particular farmers, with a wide, systematically organized knowledge base that proposes solutions to shared challenges.
Long-Chain Polyunsaturated Fatty Acid Status at Birth and Development of Childhood Allergy: A Systematic Review
Authors: Decsi Tamás , Marosvölgyi Tamás , Muszil Eszter , Bódy Blanka , Szabó Éva
Published: April 2022

The associations of fetal fatty acids status to immune-related health parameters later in life are unclear. Our aim is to collect all available information on the relationship between fatty acid status at birth and allergy in childhood. Systematic literature search was performed on Ovid MEDLINE, Cochrane Library, and Embase. The search retrieved 897 articles without duplicates; 14 articles remained after excluding those that did not fit into our inclusion criteria. When the dichotomous parameter of suffering or not from allergic condition in childhood was analyzed, cord blood eicosapentaenoic acid (EPA) values proved to be significantly lower in allergic than non-allergic children in four comparisons from three studies. When the linear parameters of odds ratios and relative risks for allergy were taken into consideration, high cord blood EPA, but also high docosahexaenoic acid (DHA) and high total n-3 long-chain polyunsaturated fatty acid values were associated to clinically relevant reduction (at least 38%) in eight comparisons from five studies. Within the cord blood samples, higher EPA, docosapentaenoic acid, and DHA values were significantly and negatively associated in eight correlation analyses from three studies with laboratory parameters considered to reflect allergic trait. The data reported here may provide information for defining optimal fatty acid intakes for pregnant women.