bluuebunny/crossref_metadata_2025 huggingface dataset:
Design of a Dynamic Demand Response Model Through Intelligent Clustering Algorithm Based on Load Forecasting in Smart Grid
Authors: Lakshmanan Priya , B Venugopal Gomathi
Published: June 2022

The development of smart metering technology empowers power reforms, which allows effective implementation of demand response programs to effectively operate the power grid. The systematic analysis of smart meter data plays a vital role for both consumers and utilities to reduce their costs and improve the efficiency of power management. In this paper, a machine learning algorithm is proposed to recommend the appropriate Demand Response (DR) program for the consumer in a real-time environment, tailored with dynamic pricing. The systematic recommendation can be made by integrating time series forecasting, consumer clustering, and DR analysis. The smart meter data of the 28 consumers for 108 weeks are recorded and applied to the ARIMA time series forecast algorithm. The smart meter data and ARIMA time series forecast data are combined and fed to the Agglomerative Hierarchical clustering algorithm to cluster consumers based on their usage and demand pattern. Clusters are analysed to identify a suitable DR program for the consumer. The results show that the proposed machine learning method effectively clusters consumers and implements the DR program in the smart grid environment.
Multi-Criteria Optimization of Vehicle-to-Grid Service to Minimize Battery Degradation and Electricity Costs
Authors: Javor Dario , Raicevic Nebojsa , Klimenta Dardan , Janjic Aleksandar
Published: June 2022

Increased use of renewable energy sources in energy sector as well as improvements and electrification in transportation sector significantly contribute to reduction of green-house gasses emissions and mitigation of problems with fossil fuel dependency. Optimal integration of electric vehicles (EVs) into the grids and their charging/discharging schedules have to be realized in accordance with electricity demand, day-ahead electricity market prices and intermittency of photovoltaic and wind generators electricity production. A microgrid that includes non-deferrable loads, renewable energy sources, EV fleet and its charging station is analyzed in this paper. Its Vehicle-to-Grid (V2G) service is optimized with the aim of minimizing the operational costs and obtaining peak load shaving and valley filling of the load curve, which is especially effective in the case of EVs fleet with occupational time intervals known in advance.
Optimized schedule of EVs charging and discharging is obtained as a result of the procedure that uses multi-criteria optimization function. These criteria include minimization of microgrid electricity costs as the local aggregator’s benefit, maximization of the flattening of total microgrid demand curve as main grid operator’s benefit, and minimization of battery degradation (due to a number of charging/discharging cycles) as EVs owner’s benefit which is the novelty of this paper. Experimental analysis is performed on several scenarios and program Lingo is used to solve the optimization problem.
Costal vein chaetotaxy, a neglected character source in Fanniidae and Muscidae (Diptera: Calyptratae)
Authors: Michelsen Verner
Published: June 2022

The present study examines whether the chaetotaxy of the costal vein in the calyptrate families Fanniidae and Muscidae deserves more attention in phylogenetic and taxonomic contexts. An overview of the macrotrichia and their arrangement on wing vein C is given. Special attention is given to the presence/absence of ventral and dorsal setulae on the costal sectors CS1‒3. This is described as one variable character (A) with nine states (A0‒A8). Specimens of both sexes (when possible) of each species belonging to 4 of a total of 5 fanniid genera and 115 of a total of 179 muscid genus-group taxa were examined and scored for character A. It was found that the presumed ancestral state of character A differs between the two families. It is further shown that the main transformational trend in character A in Muscidae has been bi-directional, leading either to the loss of ventral setulae or the gain of dorsal setulae. The utility of character A in the Fanniidae and Muscidae is many-sided and involves taxa ranging from species to family. It is concluded that character A and other aspects of costal chaetotaxy deserve more attention in morphology-based studies of calyptrate flies.
Importancia de las competencias informacionales en educación superior. Comparativa España-México
Authors: Reche Urbano Eloísa , Quintero Ordóñez Belén , González López Ignacio , Maldonado Berea Guadalupe Aurora
Published: June 2022

La adquisición de las Competencias Informacionales por parte del alumnado universitario para el desarrollo de trabajos académicos se ha convertido en un elemento clave en su proceso formativo. El objetivo de este estudio ha consistido en identificar los elementos diferenciales en la importancia y los mecanismos motivacionales que se les otorga a dichas competencias en las titulaciones de Educación de la Universidad de Córdoba (España) y la Universidad Autónoma Benito Juárez de Oaxaca (México). Los resultados revelan que estas competencias son valiosas para su desarrollo académico, otorgándole mayor relevancia, en la mayoría de sus elementos, el alumnado mexicano frente al español.
Perspectiva inclusiva en el currículo de Educación Primaria desde el Diseño Universal para el Aprendizaje: un estudio comparado
Authors: Cortés Mario , Arias Ana Rosa , Ferreira Camino
Published: June 2022

Esta investigación tiene como objetivo explorar la presencia del Diseño Universal para el Aprendizaje (DUA) en el currículo español de Educación Primaria, tanto a nivel general como de Comunidad Autónoma. El estudio presenta un método basado en el diseño descriptivo de análisis mixto, utilizando el análisis documental como metodología de investigación. La fuente de análisis ha sido la normativa estatal y autonómica española que desarrolla el currículo en Educación Primaria. Para el análisis de datos se ha utilizado el software MAXQDA 2020. Los resultados evidencian que los fundamentos del DUA predominan en los currículos desarrollados por las Comunidades Autónomas, y se concluye que todavía queda mucho camino por recorrer en el ámbito de la educación inclusiva y el DUA. A modo de conclusiones y discusión, la elaboración de un currículo basado en el DUA supone una oportunidad clave para fortalecer la participación, sobre todo del alumnado y de las familias en el currículo. La flexibilidad para adecuar la diversidad al alumnado debe ser objeto de especial atención.
Abduktive bevægelser mellem ’Mysteries’ og ’My-Stories’
Authors: Møller Britta
Published: June 2022

Denne artikel retter blikket mod kvalitativ forskning som abduktive bevægelser af levede og levende erfaringer i interaktioner med konkrete situationer. Med afsæt i to centrale pragmatiske begreber, brud og kontinuitet, relateret til forståelsen af erfaringer, betegnes dette som bevægelser mellem ’mysteries’ (brud) og ’my-stories’ (kontinuitet). Artiklen trækker på forfatterens erfaringer, som er gjort i et  længerevarende eksperimentelt og kollaborativt studie af læring i ældreplejen og på en social- og sundhedsskole. Begreberne ’levende resonanskasse’ og ’levet database’ anvendes til at beskrive aspekter af forskerens mystory, som bringes i samspil med det, som sker i konkrete situationer. Artiklen reflekterer over, hvordan forskerens fortælling og identitet kommer i tilblivelse gennem forskningens tilblivelse, og hvordan dette bidrager til vidensudvikling. Dette er således, at forskerens my-stories tager form i takt med, at forskningen skaber viden om feltet. Artiklen bidrager dermed med et perspektiv på, hvordan forskeren kan gå kvalitativt til verden på en nytænkende måde, der kan bidrage til gensidig erfaringsdannelse og fælles vidensudvikling.
At udføre kvalitativ forskning med personer med kognitive funktionsnedsættelser
Authors: Thøgersen Cecilie Marie Schmidt , Glintborg Chalotte
Published: June 2022

I takt med et øget fokus på det psykosociale bidrag til rehabiliteringen efter erhvervet hjerneskade og andre sygdomme som leder til kognitive funktionsnedsættelser, er behovet for at kunne foretage kvalitativ forskning af høj kvalitet med denne gruppe steget. Derfor er formålet med denne artikel at belyse og diskutere nogle af de metodiske udfordringer samt styrker vi har mødt i det forskningsdrevne møde medpersoner med erhvervet hjerneskade (EH). Dermed bidrager denne artikel til en metodisk diskussion som i høj grad er anerkendt som vigtig, men kun i begrænset omfang diskuteres (Glintborg, 2019; Paterson & Scott-Findlay, 2002). Gennem artiklen diskuteres det, hvordan tilpasningen af metodiske tilgange til interviewet, kan lade sig inspirere af den allerede veldokumenterede viden om tilpasningen af terapeutiske samtaler med personer med EH (f.eks. Gallagher et al., 2019). Der arbejdes ud fra fem overordnede grupper af kognitive vanskeligheder og hvordan interviewet som metode bedst muligt tilpasses disse, samtidig med at berettigelse af de kvalitative metoder diskuteres indenfor forskningsområdet.
Impostor-fænomen blandt fremspirende voksne
Authors: Laursen Marie Gamborg , Sandberg Katja
Published: June 2022

Til trods for stigende opmærksomhed på impostor-fænomenet (herefter IF) de seneste år, er mængden af kvalitativ forskning inden for området særdeles sparsom. Formålet med denne artikel er derfor at udføre en kvalitativ undersøgelse for at få indsigt i følelser, tanker og adfærd associeret med oplevelsen af IF blandt unge voksne. Livsperioden, som unge voksne befinder sig i, anskues inden for en teoretisk rammeforståelse om fremspirende voksenliv (eng. emerging adulthood). Analysen udføres på baggrund af interviewdata fra ni unge voksne. Fundene indikerer, at unge voksne oplever og håndterer IF på særdeles komplekse måder, som ofte kompliceres af udviklingsmæssige udfordringer i deres uddannelses- og arbejdsmæssige kontekster. Baseret på analysens resultater og den efterfølgende diskussion, konkluderes det, at selvom eksisterende teori og fund om IF omfatter fællestræk ved oplevelsen af IF, kan dette ikke fyldestgørende indfange de unge voksnes nuancerede, personlige oplevelser. Dette studie illustrer således, hvordan den kvalitative tilgang kan berige forståelsen af IF.
Fællesskabets betydning i selvansvarliggørelsens tidsalder
Authors: Pedersen Sofie
Published: June 2022

Denne artikel tager udgangspunkt i recovery-tilgangens implicitte fordring om selvansvar ift. psykisk lidelse og problematiserer måden, hvorpå dette individualiseres som en del af arbejdet med recovery. Med afsæt i kulturhistorisk virksomhedsteori og økologisk psykologi søger artiklen at udforske og diskutere, hvordan det individuelle og kollektive ansvar er intimt forbundet, og hvad dette betyder i en socialpsykiatrisk praksissammenhæng. Det empiriske materiale udgøres af deltagerobservationer fra det japanske socialpsykiatriske tilbud, Bethel House, hvor man arbejder ud fra et motto om ”by myself, with others”. Her er arbejdet til dels centreret omkring ’tohjisha kenkyu’, en udforskende tilgang til psykiske vanskeligheder, og til dels et stærkt praksisfællesskab med fokus på fælles produktion af bl.a. jordbær og kombu. Artiklen påpeger nødvendigheden af en tydeligere prioritering af meningsfulde sociale fællesskaber i det socialpsykiatriske recovery-arbejde og et blik for betydningen af noget (meningsfuldt) at forpligte sig på – ellers risikerer fordringen om selv- ansvar at blive et tiltag, der fastlåser mennesker yderligere i deres tilværelser.
A computed tomography-based analysis of the structure of the mandible according to age and sex
Authors: Jung Soyeon , Yun Hyunjong , Chung Chul Hoon , Kim Kuylhee , Chang Yongjoon
Published: June 2022

Background: The primary objectives of mandibular surgery are to achieve optimal occlusion, low sensory disturbance, and adequate fixation with early movement. In-depth knowledge of the mandibular structure is required to achieve these goals. This study used computed tomography (CT) to evaluate the mandibular cortical thickness and cancellous space according to age and sex.Methods: We enrolled 230 consecutive patients, aged 20 to 50 years, who underwent CT scanning. The cortex and cancellous space centered around the inferior alveolar nerve (IAN) canal were measured at two specific locations: the lingula and second molar region. Statistical analysis of differences according to increasing age and sex was performed.Results: The t-test revealed that the cancellous space and cortical thickness differed significantly with respect to the threshold of 35 years of age. Both cortical thickness and cancellous space in the molar region were negatively correlated with age. Meanwhile, both cortical thickness and cancellous space in the lingula region showed a positive correlation with age. With respect to sex, significant differences in the cancellous space at the molar region and the cortical thickness at the lingula were observed. However, no further statistically significant differences were observed in other variables with respect to sex. The sum of each measurement on the mandibular body reflected the safe distance from the surface of the outer cortex to the IAN canal. The safe distances also showed statistically significant differences between those above and below 35 years of age.Conclusion: Knowledge of the anatomical structure of the mandible and of changes in bone structure is crucial to ensure optimal surgical outcomes and avoid damage to the IAN. CT examination is useful to identify changes in the bone structure, and these should be taken into account in the planning of surgery for older patients.
Do closed reduction and fracture patterns of the nasal bone affect nasal septum deviation?
Authors: Choi Jun Ho , Oh Hyun Myung , Hwang Jae Ha , Kim Kwang Seog , Lee Sam Yong
Published: June 2022

Background: Many severe nasal bone fractures present with septal fractures, causing postoperative septal deviation and negatively affecting the patients’ quality of life. However, when a septal fracture is absent, it is difficult to predict whether surgical correction can help minimize nasal septal deviation postoperatively. This study determined whether performing closed reduction on even mildly displaced nasal bone fracture could deter the outcome of septal deviation.Methods: We retrospectively reviewed the data of 116 patients aged 21–72 years who presented at the outpatient clinic and emergency room with fractures of nasal bones only without any involvement of the septum from January 2014 to December 2020. Patients were classified into three fracture type groups: A (unilateral), B (bilateral), and C (comminuted with depression). The degree of septal deviation was calculated by measuring the angle between the apex of the most prominent point and the crista galli in the coronal view on computed tomography images. The difference between the angles of the initial septal deviation and that of the follow-up was calculated and expressed as delta (Δ).Results: Closed reduction tended to decrease the postoperative septal deviation in all fracture types, but the values were significantly meaningful only in type A and B fractures. In the surgical group, with type A as the baseline, type B showed a significantly larger Δ value, but type C was not significantly different, although type C showed a smaller Δ value. In the conservative group, with type A as the baseline, the other fracture types presented significantly lower Δ values.Conclusion: For all fracture types, closed reduction significantly decreased the extent to which the nasal septum likely deviated. Therefore, when a patient is reluctant to undergo closed reduction, physicians should address the possible outcomes and prognosis of untreated nasal bone fractures.
Current strategies for aesthetic soft tissue refinement in nasal reconstruction
Authors: Kim Min Ji , Lim Hyoseob , Park Dong Ha
Published: June 2022

The challenges of successful nasal reconstruction, which are related to the anatomical complexity of the region, have been extensively studied. Revisional operations are often required to achieve proper nasal reconstruction, with results resembling the premorbid nasal status. This is necessary to ensure the quality of life of skin cancer patients. Fundamental nasal reconstruction requires both proper soft tissue coverage and proper function. However, earlier studies in the field primarily focused on the functional aspect of nose reconstruction, although the cosmetic aspect is also an important factor to consider. In response to this need, many recent studies on nose reconstruction have proposed various refinement strategies to improve aesthetic satisfaction. Most plastic surgeons accept the nasal aesthetic subunit principle as a standard for nasal reconstruction. This review outlines the commonly used surgical refinement options and management strategies for postoperative complications based on the subunit principle. In patients with nasal defects, a proper technical strategy might help minimize revision operations and optimize the long-term results.
Kitlesel İmalat Sistemlerinde Dijital İkiz Kullanılarak Gerçek Zamanlı Üretim Çizelgeleme ve Tekstil Sektöründe Bir Uygulama
Authors: BAL Alperen , GEVREK Hilal , DEMİR Sedefnur
Published: June 2022

Üretim ortamının dinamik yapısı planlanmayı güçleştirmektedir. Gelişen teknoloji ile birlikte dijital ikiz, üretim süreçlerine etkin çözümler sunabilmek amacıyla artan bir şekilde kullanılmaya başlanmıştır. Bu çalışmada, kitlesel imalat sistemlerinde üretimin planlanması amacıyla simülasyon temelli dijital ikiz ile bir çizelgeleme modeli önerilmiştir. Böylece çözümü zor olan üretim çizelgeleme problemlerine yenilikçi ve uygulanabilir bir yaklaşım önerilmesi amaçlanmıştır. Üretim hattının bir kopyası olan ve gerçek zamanlı veri ile entegre edilmiş model, hammadde stokları, üretim süreleri, hazırlık süreleri, vardiya değişimleri ve mola zamanları, bakım ve arıza kaynaklı duruşlar gibi birçok üretim parametresini dikkate almaktadır. Önerilen yaklaşımın gerçek hayat uygulamasını göstermek amacıyla, kumaş imalatı yapan bir tekstil işletmesinde üretim hattının dijital ikizi oluşturulmuş ve örgü makineleri için işlerin sıraları belirlenmiştir. Model ile her bir siparişin zamanında tamamlanma olasılığı belirlenerek risk analizi yapılabilmektedir. Böylece yüksek riske sahip siparişler yeniden çizelgelenerek olası gecikmelerden kaçınılabilmektedir.
Assessment of the Antibacterial Potency of Usnea sp. against Foodborne Pathogens
Authors: TOKSÖZ Orçun , TÜRKMENOĞLU İpek , BERBER Didem , SESAL Cenk
Published: June 2022

ABSTRACT

The increase in the incidence of foodborne diseases has been demonstrated by epidemiological studies, and the adverse impact on the socio-economic development of countries has been also reported by health authorities. The combat against foodborne pathogens through the use of natural biosources has become the focus of recent research. Lichens produce several secondary metabolites with various biological activities including antibacterial, antifungal, anti-cancer etc. due to competition with other living things in their surrounding environment. In this perspective, we aimed to investigate the antibacterial properties of Usnea sp. that collected from Kastamonu, Turkey against five foodborne pathogens in the present study. These tested bacteria included both Gram-positive and Gram-negative ones. Our data demonstrated that the acetone extracts of Usnea sp. had antibacterial efficiencies especially against Gram-positive bacteria tested (C. perfringens, S. aureus, and B. cereus) at varying percentages. This potential antibacterial activity of Usnea sp. suggests that it can be used in the food industry. Since it has already been reported to be used in dishes or ingredients of bread, it gives the idea that it may be used as a food additive (such as a preservative, extending shelf life). However, detailed studies for its toxicity or the dosages that do not be toxic should be done.
Açık Denizde Planktondan Hidrokarbon Enerji Kaynakları Aramacılığına
Authors: KALYONCU ERGÜLER Güzide
Published: June 2022

Hidrokarbon kaynakları, yenilenebilir enerji kaynakları kullanımı artsa da, gerek nüfüs gerek endüstrideki artış nedeniyle ihtiyaç katlanarak büyümektedir. Enerji ihtiyacını karşılamak için tükenen karasal ortamdaki enerji kaynaklarından açık deniz hidrokarbon yataklarının araştırılmasına doğru süreç ilerlemektedir. Açık denizlerde hidrokarbon enerji kaynağı aramak çok sayıda belirsizlik ve bu belirsizlerde yüksek maliyetlerin daha da artmasına neden olur. Hidrokarbon alanların tespitinde uzun soluklu çabalara ihtiyaç duyulmaktadır. Bu çalışmada öncelikli alan tespitinde, planktonların hareketi sediment çökelim ilişkisi araştırılmıştır. Planktonlar, hareket kabiliyeti olmayan canlılardır. Hareketlerini, akıntının doğasına göre belirlerler. Buzullarda dahi görülebilen bu canlılar, Doğu Karadeniz’de de ağırlıklı olarak görülür. Bu son derece küçük ölü organik maddeler deniz veya okyanus tabanına düşer ve zooplankton adı verilen hayvanlardan veya fitoplankton adı verilen bitkilerden oluşur ve zamanla deniz tabanına iner ve nehirler yoluyla denize giren inorganik maddelerle karışır ve böylece enerji kaynaklarını oluşturma potansiyeli taşır. Bu çalışma plankton varlığından yola çıkarak metorolojik verilerin incelenmesi ile belirlenen tarihlerde yaklaşık 20000 km2 açık deniz alanına ait uzaktan algılama bulanıklık ve sıcaklık haritaları ile incelenmiştir. Bulanıklık haritaları için secchi disk ölçümleri ile yerinde pH, Ec ve sıcaklık ölçümü alınmıştır. İyidere- Hopa arasında sekiz alan potansiyel mikro sediment çökelme alanı olarak belirlenmiştir.
Cutaneous B-cell lymphoma mimicking a keloid: Dermoscopy-assisted diagnosis
Authors: Dar Uzair Khursheed , Bhat Yasmeen Jabeen , Wani Rohi
Published: June 2022

Primary cutaneous lymphomas are lymphoproliferative disorders having multiple heterogenous subtypes with a primary cutaneous manifestation in the absence of systemic involvement of the lymph nodes, bone marrow, or visceral organs at the time of diagnosis. Herein, we report the case of a 75-year-old male who presented with a single plaque on the back mimicking a keloid. Clinical and dermoscopic examinations led to the suspicion of a cutaneous malignancy, while histopathology and IHC confirmed a primary cutaneous B-cell non-Hodgkin’s lymphoma. The lesion responded well to a R-CHOP chemotherapy regimen.
Pyoderma gangrenosum in a patient with metastatic breast cancer
Authors: Rubaian Nouf Bin , Al-Mulhim Amnah , Shaikh Lenah
Published: June 2022

Pyoderma gangrenosum is a cutaneous ulcer diagnosed by exclusion. The underlining causes of pyoderma gangrenosum are numerous. Malignancy is a well-known underlying cause. Nonetheless, breast cancer is an uncommon cause, with few reported cases in the literature. There is no specific treatment of paraneoplastic pyoderma gangrenosum, apart from treating the underlying malignancy. Herein, we report a case of pyoderma gangrenosum with underlying breast cancer, successfully treated by systemic steroids, although the patient showed no response to anticancer therapy and expired shortly after the resolution of the cutaneous lesion. Further studies are needed to conclude the benefit of systemic steroids in paraneoplastic pyoderma gangrenosum, yet we recommend a trial of systemic steroids in the case of generalized resistant paraneoplastic pyoderma gangrenosum.
Blue scales on an “iced” scalp
Authors: Gimeno-Castillo Javier , Martínez Aracil Adriano Pablo , Menéndez Parrón Aida
Published: June 2022

Although the diagnosis of actinic keratosis (AK) is mainly clinical, dermoscopy is a highly useful and accurate diagnostic technique. The dermoscopic features of AK include the strawberry pattern with white areas, keratotic, follicular openings, a pseudonetwork, and rosettes [1]. An 82-year-old male with a personal history of type 3 autoimmune polyglandular syndrome and hypertension was referred to the dermatology department due to the presence of scaly lesions located on the scalp and forehead. A physical examination revealed asymptomatic, keratotic lesions on the forehead and in the occipital region (Fig. 1a). The patient denied the application of any product except toning shampoo for white hair. Interestingly, the lesions had a blue, superficial scale, although they clinically resembled AK. Dermoscopy evidenced an erythematous background with multiple, arctic-blue, keratotic plugs (Fig. 1b). Moreover, a superficial excision of one of the lesions was performed, evidencing solar elastosis and a chronic dermal infiltrate, as well as basal keratinocytes with loss of polarity, presenting with irregular nuclei (Fig. 2). Thus, the clinical and pathological correlation confirmed the diagnosis of AK. The lesions were treated with cryotherapy leading to their resolution. Figure 1: (a) Clinical presentation of the cutaneous lesions: numerous bluish-gray, scaly lesions in the occipital area; the patient confirmed using toning shampoo for white hair containing Acid Violet 43. (b) Dermoscopy of one of the lesions: an erythematous background, as well as numerous arctic-blue, keratotic plugs; the blue scale compatible with the iceberg sign present in AK neglecta. Figure 2: Solar elastosis and a chronic dermal infiltrate, as well as basal keratinocytes with loss of polarity presenting with irregular nuclei; findings compatible with the clinical suspicion of AK; no basophilic amorphous material present in the stratum corneum (H&E, 20×). Blue AK has been termed AK neglecta while the dermoscopic blue coloration the iceberg sign [2,3]. The latter is described to be caused both by sunscreens containing titanium dioxide [3] or shampoos containing Acid Violet (present in the shampoo that the patient used) [2]. Moreover, this exogenous pigmentation may easily be removed with alcohol [3]. Histologically, a basophilic amorphous material on the stratum corneum is described to be present [2]. A lack of this finding in our case might have been explained due to the 10% formol used to preserve the biopsy, eliminating the pigment. Recognizing this presentation is essential due to the widespread use of toning shampoos and sunscreens among the elder population.
Ovoid nests in nevocellular nevus
Authors: Hamich Soumaya , Karrakchou Basma , Znati Kaoutar , Senouci Karima
Published: June 2022

We report the case of a 34-year-old female patient with no medical history presented herself with a lesion near the intergluteal cleft evolving for more than five years and gradually increasing in size. An examination revealed a painless nodule 1.5 × 2 cm in size, of soft consistency, and with a flesh-colored pedicle base with central hyperpigmentation and a depigmented peripheral area (Fig. 1). Dermoscopy revealed a hyperpigmented cerebriform structure in the center surmounted by several white scales and bordered by an irregular melanocytic network and multiple ovoid nests (Fig. 2).
A case of persistent psoriasis occurring after influenza vaccination
Authors: Takada Maki , Yamamoto Toshiyuki
Published: June 2022

Sir, A thirty-year-old male received influenza vaccination in the upper arm. Several days later, erythema appeared on the vaccinated site and spread to the trunk and extremities. He had no family history of psoriasis. He was treated with a topical corticosteroid for three months, which yielded no effects and, thus, he was referred to our hospital. A physical examination revealed numerous erythematous, scaly macules scattered on the trunk and upper extremities and erythema with thick scales scattered on the lower extremities (Figs. 1a and 1b). The psoriasis area and severity index (PASI) score was 9.7. We performed a skin biopsy from the left lower leg. Histopathology revealed a regularly elongated epidermis, an absent granular cell layer of the epidermis, parakeratosis in the corneal layer, and subcorneal neutrophil infiltration (Fig. 1c). Immunohistochemistry revealed that CD4- and CD8-positive T-cells infiltrated into the epidermis and upper dermis, and IL-17, CD123, and TNF-a were also detected in the inflammatory cells below the epidermis. He was diagnosed with psoriasis and was started on a treatment with topical betamethasone and calcipotriol formula (Dovobet) ointment and oral cyclosporine (300 mg/day). An improvement in the skin lesions other than those in the lower extremities was observed after two months. However, the scaly, erythematous lesions on the lower legs were resistant to therapy. The treatment was continued thereafter.
Leser–Trélat syndrome: What does it hide?
Authors: Ryme Dassouli , Douhi Zakia , Tahri Kenza , Baybay Hanane , Elloudi Sara , Mernissi Fatima Zahra
Published: June 2022

Sir, Seborrheic keratoses (SKs) are common, benign, non-melanocytic epidermal tumors [1]. Still, they may be suspicious of other, more serious underlying conditions. Leser–Trélat syndrome may be considered a paraneoplastic condition characterized by the sudden onset of multiple SKs [2]. Herein, we report two cases of malignancy revealed by eruptive KS. The first case, an 83-year-old male with no notable pathological history, presented for two years with rapidly evolving lesions of the trunk over a six-month period. The patient also noticed for three months melena with transit disorders, justifying a consultation in which the diagnosis of sigmoid tumor was reached and the patient was referred for surgery. A clinical examination revealed multiple, sessile, exophytic tumors of round or oval appearance, 1 to 3 cm in diameter, well-delimited. The surface of the lesions was verrucous, brownish-black, with numerous, black, keratotic plugs (Fig. 1a). A dermoscopic examination revealed a cerebral appearance with pseudocysts and pseudocomedones (Fig. 1b). The diagnosis of seborrheic keratosis was thus reached.
Vestibular papillomatosis: A differential diagnosis of vulvar condylomas
Authors: Abdelmouttalib Asmae , Sialiti Sanae , Meziane Mariame , Senouci Karima
Published: June 2022

Sir, For a considerable time, vestibular papillomatosis (VP) has been conceived of as a secondary pathology to HPV (human papilloma virus). Nowadays, several authors are reconsidering it as an anatomical variant of the vestibular mucosa. We report a case of VP initially mistaken for vulvar condyloma. A 25-year-old female without any particular medical history presented herself to the gynecologist for genital papules, without functional signs of genital discharge or dyspareunia. A cervicovaginal smear and viral serologies for HIV and hepatitis B and C were negative, and a diagnosis of vulvar condyloma was reached. The patient was referred to the dermatology department for eventual treatment. A clinical examination revealed filiform, flexible, flesh-colored papillae 1–2 mm in diameter located on both edges of the vulva (Fig. 1). A dermoscopic examination found linear, symmetrical papillae in the vulval vestibule with abundant vessels along them (Fig. 2). There was no whitening of the lesions under the acetic acid test. The diagnosis of vestibular papillomatosis was reached, the patient was reassured, and no treatment was prescribed.
Correlation between trichoscopic findings and disease severity in female-pattern hair loss
Authors: Snehal Muddennavar , Sandhaya Prasad , Raghavendra Narasappa
Published: June 2022

Background: Female-pattern hair loss (FPHL) is a common form of hair loss in women and is referred to as androgenetic alopecia. It is characterized by diffuse reduction in hair density on the crown and frontal scalp with retention of the frontal hairline. Objective: This study aimed to examine the trichoscopic findings of FPHL and to correlate their relationship with disease severity in our tertiary care hospital. Materials and Methods: This was a prospective, observational study in which a total of thirty female patients of the age group between 18 and 45 years were included at the outpatient dermatology department within six months. The diagnosis of FPHL was based on clinical grounds. Trichoscopic evaluation was performed under the dermatoscope. Statistical significance in the difference in the outcome variables between the stages was assessed by the Fisher’s exact test. The statistical test was considered statistically significant at P < 0.05. Results: A positive correlation between clinical and trichoscopic findings with respect to disease severity was seen. HSTH > 10% was seen in all grades of FPHL. BPPS and the multi-hair follicular unit were seen in early grades of FPHL (P < 0.01); WPPS, focal atrichia, and scalp honeycomb pigmentation were seen in later grades of FPHL (P < 0.01). Conclusion: Our study showed the significance of trichoscopy in patients with FPHL. As trichoscopy may reveal early changes in hair follicle diameter before hair loss becomes clinically visible. Regular clinical and trichoscopic follow-ups are highly important to monitor disease activity and treatment tolerance.
Children’s knowledge and behavior towards the sun and photo protection (Survey of 391 children in the region of Fez, Morocco)
Authors: Kassel Jihad , Elloudi Sara , Maiouak Moncef , Jroundi Chaymae , Douhi Zakia , Baybay Hanane , El Fakir Samira , Mernissi Fatima Zahra
Published: June 2022

Background: Currently, the sun-cancer relationship is well established and it is clearly demonstrated that sun exposure during childhood increases the risk of skin cancer in later life. The main objective of our study was to evaluate the behavior and knowledge of children towards the sun, its dangers, particularly skin cancer, and the different means of photo protection. Material and methods: We conducted a descriptive cross-sectional survey using a questionnaire among students (primary and secondary) in the region of Fez (urban and rural). Results: Three hundred and eightyone children delivered a completed and usable questionnaire. The average age was 13 years, the sex ratio M/F =1,16. 71,9% of the children were from public schools and 66% had moderately pigmented skin. Among the 97% of children who practice outdoor activities during the vacations, 30.5% like to tan, and almost half spend more than 30 minutes a day under the sun. 69.6% of the children declared that they take with them during the vacations at least one sun protection product (sun cream, hat, sunglasses…) Concerning the application of sunscreen,72.2% of children used sunscreen during their vacations, 27.7% reapply it every two hours and 82.4% apply it only in summer. At school, 72.6% of the students said they look for shade during recess and only 10% apply sun cream. 55, 8% of the children think that the sun can be dangerous, 44.2% know that there is a relationship between the sun and skin cancer, 52% think that the sun can cause burns and 37% skin aging. 71% said they have already been told by a parent that they should protect themselves from the sun,41.5% were advised by their teachers and only 31% by a doctor.43% of our children had heard of skin cancer and almost half of these children know that it can be caused by the sun. In general, the assessment of children's knowledge was average in about half of the cases, we noted that children are better protected during the summer vacations than at school. We also focused on the role of parents, schools, doctors and media in raising children's awareness, which was not sufficient.
Reactive infectious mucocutaneous eruption in a young-adult with COVID-19
Authors: Bainvoll Liat , Miller Melanie , Worswick Scott
Published: June 2022

In this case report, we detail the case of a young adult with a recurrent case of Reactive Infectious Mucocutaneous Eruption (RIME) in the setting of Sars-COV-2 infection, the second time this has been reported in the literature. We review the more common causes of RIME, including Chlamydophila pneumoniae, metapneumovirus, parainfluenza, rhinovirus, enterovirus, and influenza; and we discuss patient characteristics in other reported cases of RIME secondary to COVID-19 and the features of recurrent RIME seen in patients reported in the literature. Our patient had the characteristic severe mucosal involvement seen with RIME, and was treated with supportive care alone and experienced rapid improvement in symptoms.
Interpersonal conflicts motivated by jealousy or revenge as a condition for committing violent crimes
Authors: Sergeeva Anzhelika Anatol'evna
Published: June 2022

The subject of the study is violent interpersonal conflicts motivated by emotional states of jealousy and revenge or their combination. The research used a methodology based on the principles of dialectical cognition and including generally recognized scientific methods used in conflictology and jurisprudence. The author refers to moral norms in their relationship with the law, as well as in their perception by a person committing a violent crime motivated by jealousy or revenge. On this basis, recommendations have been developed that have scientific value for the further development of the theory of interpersonal conflicts and practical significance for use in the process of establishing the circumstances of the commission of violent crimes related to their subjective side. Author established the features of the intellectual element of the intent of a person committing a violent crime motivated by jealousy or revenge. Due to a distorted perception of moral norms, such a person has a tolerant attitude to violence, which in his mind is considered permissible out of jealousy, revenge or in the presence of a combination of these motives. The scope of application of the research results is practical conflictology and prevention of violent crimes. The scientific novelty of the study is due to the author's approach to establishing the peculiarities of the subject's perception of violent crime of moral norms, the distorted interpretation of which allows him to show aggression out of jealousy or revenge. It is substantiated that a subject who commits a crime out of jealousy or revenge violates generally recognized norms of morality, and his behavior in the event of an interpersonal conflict has an increased public danger equivalent to the public danger of hooligan motives. Taking into account these circumstances both in the development of methods for resolving interpersonal conflicts and in the prevention of violent crimes seems necessary.
Twenty Reasons Why Cross-Curricular Citizenship Education Might Struggle to Take Flight in Secondary Schools: An Autoethnographic Review
Authors: Brett Peter
Published: June 2022

The paper combines an autoethnographic approach with a literature review of general and discipline-specific research linked to the theme of cross-curricular citizenship education (“CE”) from the 1990s to the present. It identifies 20 reasons why cross-curricular CE struggles
to take flight in secondary schools. These reasons are organized into four categories: structural, epistemological, attitudinal and pedagogical. While the focus is mainly upon citizenship education in England (and, to a lesser extent, in Australia), the paper suggests that the barriers identified
exist in most nations.
Critical cases in neutral functional differential equations, arising from hydraulic engineering
Authors: R�svan Vladimir
Published: June 2022

This paper starts from several applications described by initial/boundary value problems for \(1D\) (time and one space variable) hyperbolic partial differential equations whose basic properties and stability of equilibria are studied throughout the same properties for certain associated neutral functional differential equations. It is a common fact that asymptotic stability for neutral functional differential equations is normally obtained under the assumption of asymptotic stability of the difference operator associated to the aforementioned neutral functional differential equations. However the physically meaningful applications presented in the paper have the associated difference operator(s) in critical cases (their stability is, generally speaking, non-asymptotic). Consequently the stability of the considered application models is either non-asymptotic or fragile (in a sense introduced in the paper). The models represent an overview gathered from various fields, processed here in order to emphasize the associated neutral functional differential equations which, consequently, are a challenge to the usual approaches. In the concluding part there are suggested possible ways to overcome these difficulties.
Northern Sparks
Authors: Century Michael
Published: June 2022

An “episode of light” in Canada sparked by Expo 67 when new art forms, innovative technologies, and novel institutional and policy frameworks emerged together.

Understanding how experimental art catalyzes technological innovation is often prized yet typically reduced to the magic formula of “creativity.” In Northern Sparks, Michael Century emphasizes the role of policy and institutions by showing how novel art forms and media technologies in Canada emerged during a period of political and social reinvention, starting in the 1960s with the energies unleashed by Expo 67. Debunking conventional wisdom, Century reclaims innovation from both its present-day devotees and detractors by revealing how experimental artists critically challenge as well as discover and extend the capacities of new technologies.

Century offers a series of detailed cross-media case studies that illustrate the cross-fertilization of art, technology, and policy. These cases span animation, music, sound art and acoustic ecology, cybernetic cinema, interactive installation art, virtual reality, telecommunications art, software applications, and the emergent metadiscipline of human-computer interaction. They include Norman McLaren's “proto-computational” film animations; projects in which the computer itself became an agent, as in computer-aided musical composition and choreography; an ill-fated government foray into interactive networking, the videotext system Telidon; and the beginnings of virtual reality at the Banff Centre. Century shows how Canadian artists approached new media technologies as malleable creative materials, while Canada undertook a political reinvention alongside its centennial celebrations. Northern Sparks offers a uniquely nuanced account of innovation in art and technology illuminated by critical policy analysis.
US women screen at low rates for both cervical and colorectal cancers than a single cancer: a cross-sectional population-based observational study
Authors: Harper Diane M , Plegue Melissa , Jimbo Masahito , Sheinfeld Gorin Sherri , Sen Ananda
Published: June 2022

Background:

Using screen counts, women 50–64 years old have lower cancer screening rates for cervical and colorectal cancers (CRC) than all other age ranges. This paper aims to present woman-centric cervical cancer and CRC screenings to determine the predictor of being up-to-date for both.

Methods:

We used the Behavioral Risk Factor Surveillance System (BRFSS), an annual survey to guide health policy in the United States, to explore the up-to-date status of dual cervical cancer and CRC screening for women 50–64 years old. We categorized women into four mutually exclusive categories: up-to-date for dual-screening, each single screen, or neither screen. We used multinomial multivariate regression modeling to evaluate the predictors of each category.

Results:

Among women ages 50–64 years old, dual-screening was reported for 58.2% (57.1–59.4), cervical cancer screening alone (27.1% (26.0–28.2)), CRC screening alone (5.4% (4.9–5.9)), and neither screen (9.3% (8.7–9.9)). Age, race, education, income, and chronic health conditions were significantly associated with dual-screening compared to neither screen. Hispanic women compared to non-Hispanic White women were more likely to be up-to-date with cervical cancer screening than dual-screening (adjusted odds ratio [aOR] = 1.39 (1.10, 1.77)). Compared to younger women, those 60–64 years are significantly more likely to be up-to-date with CRC screening than dual-screening (aOR = 1.75 (1.30, 2.35)).

Conclusions:

Screening received by each woman shows a much lower rate of dual-screening than prior single cancer screening rates. Addressing dual-screening strategies rather than single cancer screening programs for women 50–64 years may increase both cancer screening rates.

Funding:

This work was supported by NIH through the Michigan Institute for Clinical and61 Health Research UL1TR002240 and by NCI through The University of Michigan Rogel Cancer62 Center P30CA046592 grants.
Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes
Authors: Zhang Jingsong , Cunningham Jessica , Brown Joel , Gatenby Robert
Published: June 2022

Background:

Abiraterone acetate is an effective treatment for metastatic castrate-resistant prostate cancer (mCRPC), but evolution of resistance inevitably leads to progression. We present a pilot study in which abiraterone dosing is guided by evolution-informed mathematical models to delay onset of resistance.

Methods:

In the study cohort, abiraterone was stopped when PSA was <50% of pretreatment value and resumed when PSA returned to baseline. Results are compared to a contemporaneous cohort who had >50% PSA decline after initial abiraterone administration and met trial eligibility requirements but chose standard of care (SOC) dosing.

Results:

17 subjects were enrolled in the adaptive therapy group and 16 in the SOC group. All SOC subjects have progressed, but four patients in the study cohort remain stably cycling (range 53–70 months). The study cohort had significantly improved median time to progression (TTP; 33.5 months; p<0.001) and median overall survival (OS; 58.5 months; hazard ratio, 0.41, 95% confidence interval (CI), 0.20–0.83, p<0.001) compared to 14.3 and 31.3 months in the SOC cohort. On average, study subjects received no abiraterone during 46% of time on trial. Longitudinal trial data demonstrated the competition coefficient ratio (αRS/αSR) of sensitive and resistant populations, a critical factor in intratumoral evolution, was two- to threefold higher than pre-trial estimates. Computer simulations of intratumoral evolutionary dynamics in the four long-term survivors found that, due to the larger value for αRS/αSR, cycled therapy significantly decreased the resistant population. Simulations in subjects who progressed predicted further increases in OS could be achieved with prompt abiraterone withdrawal after achieving 50% PSA reduction.

Conclusions:

Incorporation of evolution-based mathematical models into abiraterone monotherapy for mCRPC significantly increases TTP and OS. Computer simulations with updated parameters from longitudinal trial data can estimate intratumoral evolutionary dynamics in each subject and identify strategies to improve outcomes.

Funding:

Moffitt internal grants and NIH/NCI U54CA143970-05 (Physical Science Oncology Network).