bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of tension band wiring and other tibial tuberosity advancement techniques for cranial cruciate ligament repair: an experimental study
Authors: McCartney William , Ober Ciprian , Benito Maria , MacDonald Bryan
Published: October 2019

Background

Cranial cruciate ligament (CCL) rupture is one of the most common causes of limb lameness in dogs. Surgical techniques based on tibial osteotomies such as tibial plateau leveling osteotomy and tibial tuberosity advancement are used to eliminate dynamic thrust. Tibial tuberosity advancement (TTA) uses an osteotomy fixated by cage, plates, forks and screws to change the relationship of the patellar tendon and tibial plateau angle. Tension band wiring technique is one of the most common surgical methods used to treat a tension fracture and remains the gold standard for the treatment of tibial tuberosity fractures. In this study, we compared experimentally the biomechanical effect of application of tension band wiring compared to other techniques for the fixation of the TTA osteotomy. The techniques compared to are standard commercially available systems for TTA fixation.

Results

Tension band wiring (TBW) presented the higher resistance to failure compared to all the other surgical procedures, with the highest values found in the TBW group with 1.47 ± 0.07 N and the lowest in the TTA cage (0.82 ± 0.08) and TTA-2 (0.85 ± 0.06) groups with statistically significant differences in all cases (P < 0.001). TTA rapid and TTA plate groups exhibited a similar strength, and same happened between TTA-2 and TTA cage groups. All the other comparisons by pair were significantly different with P < 0.001.

Conclusions

Results suggest that fixating the osteotomy with tension band wiring increases the strength of the fixation and decrease the risk of implant failure. Further clinical studies are needed to demonstrate in vivo reliability and to test different variables such as size and weight of dogs. These results could have important clinical implications in the treatment of CCL ruptures.
Neglected tropical diseases in the People’s Republic of China: progress towards elimination
Authors: Qian Men-Bao , Chen Jin , Bergquist Robert , Li Zhong-Jie , Li Shi-Zhu , Xiao Ning , Utzinger Jürg , Zhou Xiao-Nong
Published: October 2019

Since the founding of the People’s Republic of China in 1949, considerable progress has been made in the control and elimination of the country’s initial set of 11 neglected tropical diseases. Indeed, elimination as a public health problem has been declared for lymphatic filariasis in 2007 and for trachoma in 2015. The remaining numbers of people affected by soil-transmitted helminth infection, clonorchiasis, taeniasis, and echinococcosis in 2015 were 29.1 million, 6.0 million, 366 200, and 166 100, respectively. In 2017, after more than 60 years of uninterrupted, multifaceted schistosomiasis control, has seen the number of cases dwindling from more than 10 million to 37 600. Meanwhile, about 6000 dengue cases are reported, while the incidence of leishmaniasis, leprosy, and rabies are down at 600 or fewer per year. Sustained social and economic development, going hand-in-hand with improvement of water, sanitation, and hygiene provide the foundation for continued progress, while rigorous surveillance and specific public health responses will consolidate achievements and shape the elimination agenda. Targets for poverty elimination and strategic plans and intervention packages post-2020 are important opportunities for further control and elimination, when remaining challenges call for sustainable efforts.
Binge eating symptoms prevalence and relationship with psychosocial factors among female undergraduate students at Palestine Polytechnic University: a cross-sectional study
Authors: Badrasawi Manal M. , Zidan Souzan J.
Published: October 2019

Background

Eating disorders pose a serious challenge to health services due to psychosocial and medical problems. Binge eating disorder (BED) is characterized as a pattern of overeating episodes followed by shame, distress and guilty feelings. Among eating disorders, BED has the highest prevalence, especially among females. The literature reported that BED is associated with nutritional status, socio-demographic factors, and psychological factors in different countries. This study aims to examine the prevalence of binge eating symptoms and its relationship with selected variables (i.e. socio-demographics, nutritional status and dietary habits).

Methods

One hundred fifty-four female undergraduate students, from three different faculties at Palestine Polytechnic University, participated in the study. All the students who consented to join the study were assessed in terms of weight status using body mass index, dietary habits and medical profile. The screening for presence of binge eating symptoms was done using BEDS-7. The psychosocial factors were assessed by validated Arabic version of DASS-21.

Results

Half of the participants (50%) had binge eating symptoms. No association between binge eating symptoms and socio-demographic variables was found. Similarly, binge eating symptoms was not related to body weight status, however, it was associated with eating between meals and number of snacks. A significantly higher score on depression, stress and anxiety was found among binge eaters than non-binge eaters.

Conclusion

It was concluded that binge eating symptoms have considerable prevalence among the study participants, and it was significantly correlated with psychosocial factors. Future studies are needed to examine other risk factors and correlations. Educational programs are also recommended to increase the awareness of eating disorders as well as to promote healthy eating patterns.
Review: corneal endothelial cell derivation methods from ES/iPS cells
Authors: Hatou Shin , Shimmura Shigeto
Published: October 2019

Globally, approximately 12.7 million people are awaiting a transplantation, while only 185,000 cases of corneal transplantation are performed in a year. Corneal endothelial dysfunction (bullous keratopathy) due to Fuchs’ corneal endothelial dystrophy, or insults associated with intraocular surgeries, shared half of all indications for corneal transplantation. Regenerative therapy for corneal endothelium independent of eye bank eyes has great importance to solve the large supply-demand mismatching in corneal transplantation and reduce the number of worldwide corneal blindness. If corneal endothelial cells could be derived from ES or iPS cells, these stem cells would be the ideal cell source for cell therapy treatment of bullous keratopathy. Four representative corneal endothelial cell derivation methods were reviewed. Components in earlier methods included lens epithelial cell-conditioned medium or fetal bovine serum, but the methods have been improved and materials have been chemically more defined over the years. Conditioned medium or serum is replaced to recombinant proteins and small molecule compounds. These improvements enabled to open the corneal endothelial developmental mechanisms, in which epithelial-mesenchymal and mesenchymal-endothelial transition by TGF beta, BMP, and Wnt signaling have important roles. The protocols are gradually approaching clinical application; however, proof of efficacy and safety of the cells by adequate animal models are the challenges for the future.
A practical workflow using quantitative interpretation of seismic amplitudes to derisk infill wells in deepwater Gulf of Mexico: The Auger example
Authors: Sang Liqin , Klein-Helmkamp Uwe , Cook Andrew , Jimenez Juan R.
Published: October 2019

Seismic direct hydrocarbon indicators (DHIs) are routinely used in the identification of hydrocarbon reservoirs and in the positioning of drilling targets. Understanding seismic amplitude reliability and character, including amplitude variation with offset (AVO), is key to correct interpretation of the DHI and to enable confident assessment of the commercial viability of the reservoir targets. In many cases, our interpretation is impeded by limited availability of data that are often less than perfect. Here, we present a seismic quantitative interpretation (QI) workflow that made the best out of imperfect data and managed to successfully derisk a multiwell drilling campaign in the Auger and Andros basins in the deepwater Gulf of Mexico. Data challenges included azimuthal illumination effects caused by the presence of the Auger salt dome, sand thickness below tuning, and long-term production effects that are hard to quantify without dedicated time-lapse seismic. In addition, seismic vintages with varying acquisition geometries led to different QI predictions that further complicated the interpretation story. Given these challenges, we implemented an amplitude derisking workflow that combined ray-based illumination assessments and prestack data observations to guide selection of the optimal seismic data set(s) for QI analysis. This was followed by forward modeling to quantify the fluid saturation and sand thickness effects on seismic amplitude. Combined with structural geology analysis of the well targets, this workflow succeeded in significantly reducing the risk of the proposed opportunities. The work also highlighted potential pitfalls in AVO interpretation, including AVO inversion for the characterization of reservoirs near salt, while providing a workflow for prestack amplitude quality control prior to inversion. The workflow is adaptable to specific target conditions and can be executed in a time-efficient manner. It has been applied to multiple infill well opportunities, but for simplicity reasons here, we demonstrate the application on a single well target.
Elastic reflectivity vectors and the geometry of intercept-gradient crossplots
Authors: Connolly Patrick
Published: October 2019

Reflectivities of elastic properties can be expressed as a sum of the reflectivities of P-wave velocity, S-wave velocity, and density, as can the amplitude-variation-with-offset (AVO) parameters, intercept, gradient, and curvature. This common format allows elastic property reflectivities to be expressed as a sum of AVO parameters. Most AVO studies are conducted using a two-term approximation, so it is helpful to reduce the three-term expressions for elastic reflectivities to two by assuming a relationship between P-wave velocity and density. Reduced to two AVO components, elastic property reflectivities can be represented as vectors on intercept-gradient crossplots. Normalizing the lengths of the vectors allows them to serve as basis vectors such that the position of any point in intercept-gradient space can be inferred directly from changes in elastic properties. This provides a direct link between properties commonly used in rock physics and attributes that can be measured from seismic data. The theory is best exploited by constructing new seismic data sets from combinations of intercept and gradient data at various projection angles. Elastic property reflectivity theory can be transferred to the impedance domain to aid in the analysis of well data to help inform the choice of projection angles. Because of the effects of gradient measurement errors, seismic projection angles are unlikely to be the same as theoretical angles or angles derived from well-log analysis, so seismic data will need to be scanned through a range of angles to find the optimum.
Edward Said’s Home, Martin Buber’s Mailbox
Authors: Abowd Thomas
Published: October 2019

This article examines the primary means by which Israeli settler colonialism has appropriated and reconfigured Jerusalem since 1948—discursively no less than physically. It analyzes how the Jewish state, building on the colonial suppositions and discourses of the pre-1948 Zionist movement, has sought to efface Palestinian attachments to and histories in this contested urban realm. This piece foregrounds the life and works of Jewish Israeli philosopher Martin Buber and the binationalist, antistatist politics he sought to build in Palestine with the indigenous Arab populations before the creation of Israel in 1948. However, it also offers a critique of the ways in which even Buber and other Zionist binationalists’ dovish political positions were implicated in settler colonialism and the displacement and erasure of the Palestinians. The article details some of the ways in which the mobilization of presence and absence has been crucial to Israel’s colonization of Jerusalem and how they have been utilized in the service of the state’s drive for exclusive control over this symbolically potent city. This is done, principally, through a reading of the Palestinian house in Jerusalem in which Buber resided during his first four years in the country: the family home of Palestinian scholar and activist Edward Said. This article explores the relationship between the exiled intellectual, Said, and this structure, commandeered by Zionist forces in 1948. This article also explores some of Said’s views on colonial landscapes and binationalist futures for Israelis and Palestinians.
Uso do CDS para Estimar os Componentes do Spread dos Títulos das Empresas do Setor de Óleo e Gás
Authors: Almeida Juliano Ribeiro de , Almeida Guilherme Ribeiro de
Published: October 2019

Neste trabalho, utilizamos informações do mercado de credit default swap para medir os principais componentes do spread das empresas do setor de óleo e gás. Utilizando cerca de 20 empresas da indústria de óleo e gás composta por companhias de diversos ratings e aproximadamente 80 bonds, os resultados mostraram que a maior parte do spread corporativo do setor decorre do risco de inadimplemento. Também encontramos que o componente do spread não relacionado ao default é fortemente associado a algumas medidas de liquidez do mercado de bonds, sugerindo que a liquidez tem um papel importante na avaliação de títulos de renda fixa. Por outro lado, não encontramos evidências da importância de fatores tributários na explicação do componente do spread não relacionado à inadimplência.
Retornos Anormais no Ibovespa Utilizando Modelos para Dados de Alta Frequência
Authors: Fonseca Nelson Ferreira , Lamounier Wagner Moura , Bressan Aureliano Angel
Published: October 2019

Este artigo tem como objetivo identificar estratégias de negociação lucrativas com base nos efeitos de liderança e na defasagem entre os mercados acionários à vista e futuro no Brasil, utilizando dados de alta frequência. Para alcançar esse objetivo e com base nos dados históricos do índice Bovespa e do índice Bovespa Futuro construíram-se quatro modelos econométricos de previsão: ARIMA, ARFIMA, VAR e VECM. As estratégias de negociação testadas foram: estratégia de negociação líquida, estratégia de compra e manutenção da posição e estratégia de filtro com a média. O período de análise desse artigo estende-se de 1 de agosto de 2006 a 16 de outubro de 2009. Neste trabalho, foi possível obter retornos anormais com a utilização de estratégias de negociação com o modelo VAR sobre os efeitos de liderança e defasagem entre o índice Bovespa e o índice Bovespa Futuro.
Mensuração do Risco de Sorteio em Títulos de Capitalização
Authors: Melo Eduardo Fraga Lima de , Franklin Jr. Sergio Luis , Neves César da Rocha
Published: October 2019

Neste artigo, apresentamos uma abordagem para mensuração do risco de sorteio presente em títulos de capitalização comercializados por sociedades de capitalização. O risco de sorteio é aquele relacionado à possibilidade de perdas advindas do compromisso de pagar premiação acima do valor esperado, associadas à eventual não venda da série completa de títulos e/ou com o sorteio de títulos cujo valor pago pelo subscritor tenha sido elevado. Os resultados obtidos fornecem uma fórmula de simples aplicação que pode ser facilmente utilizada na gestão de riscos em sociedades de capitalização.
Informação Endógena, Caracterização do Risco e Retornos de Ações Variantes no Tempo
Authors: Simlai Pradosh
Published: October 2019

Neste artigo, oferecemos um novo tipo de caracterização do risco da previsibilidade de dois conhecidos padrões anormais dos retornos médios das ações: momento e reversões. O objetivo é ilustrar a importância relativa dos fatores comuns de risco e da informação endógena para explicar a variabilidade no tempo dos retornos de momento e reversão. Nossos resultados demonstram que, mesmo na presença de carteiras de investimento nulo, os spreads dos retornos médios de momento e reversão correspondem aos spreads dos coeficientes angulares da informação endógena. Os resultados empíricos corroboram a perspectiva de que várias classes de empresas reagem de forma diferente ao risco de volatilidade e, tanto o tamanho quanto a relação valor patrimonial - valor de mercado da ação médios das empresas, contém, em conjunto, importantes fontes de risco potencial. Tomados em conjunto, nossos resultados sugerem que os retornos são influenciados pelo fluxo endógeno de informações aleatórias, que é assimétrico por natureza e que pode ser usado como fator de atribuição de desempenho. Quando não se incorporam as informações endógenas assimétricas existentes, escondidas no comportamento histórico, qualquer tentativa de explorar a previsibilidade da média do retorno das ações estará sujeita a um viés de especificação não quantificado.
Desenvolvimento de uma Medida de Desempenho Comportamental
Authors: Klotzle Marcelo Cabus , Gomes Leonardo Lima , Brandão Luiz Eduardo Teixeira , Figueiredo Pinto Antonio Carlos
Published: October 2019

Desde os anos cinquenta, diversas medidas têm sido desenvolvidas com o intuito de medir o desempenho seja de investimentos, seja de escolhas envolvendo resultados incertos. Boa parte destas medidas se baseia na Teoria da Utilidade Esperada, mas desde os anos noventa algumas medidas têm sido propostas com base na Teoria da Utilidade Não-Esperada. Dentre as Teorias da Utilidade Não-Esperada destaca-se a Teoria do Prospecto, que é o alicerce das Finanças Comportamentais. Baseada nesta Teoria este estudo propõe uma nova medida de desempenho na qual são incorporadas a aversão à perda junto com as distorções das probabilidades na escolha de alternativas. Um exemplo hipotético é apresentado em que diversas medidas de desempenho, incluindo a medida nova, são comparadas entre si. Os resultados mostraram que a ordenação dos ativos variou de acordo com a medida de desempenho adotada. De acordo com o esperado, a medida de desempenho nova conseguiu captar claramente a distorção das probabilidades e a aversão à perda do tomador de decisão, ou seja, aqueles ativos com maiores desvios negativos em relação à meta foram os que tiveram o pior desempenho.
Relatório Editorial de 2012 da Revista Brasileira de Finanças
Authors: Leal Ricardo Pereira Câmara
Published: October 2019

A RBFin é o principal veículo para publicação de artigos acadêmicos em finanças do Brasil. O conteúdo da Revista permaneceu on-line e aberto e também foi mantida a revista impressa, graças ao auxílio do CNPq/Capes. A revista emprega o sistema Open Journal System para gerenciar o processo editorial. O cronograma de publicação da RBFin encontra-se rigorosamente em dia. A revista é indexada no EconLit, Google Scholar, Ebsco e Gale e listada nos diretórios JEL, DOAJ, Latindex, OpenJGate e Cabell’s. A revista foi admitida ao RedALyC e Proquest. A RBFin foi enquadrada como B1 na área de Administração do Qualis/Capes. O Corpo Editorial Científico é parcialmente renovado a cada ano e é formado por 18 membros provenientes de quatro países, sendo nove de cinco diferentes estados do Brasil. A taxa de aceitação foi de 18% para os artigos enviados em 2011, o último ano em que todos os artigos já obtiveram decisão definitiva. A média de dias entre o recebimento e a aceitação para os artigos recebidos em 2012 foi de 215. O pior caso foi de 584 dias. A média de dias entre o recebimento e a publicação foi de 317. O pior caso foi de 760 dias. Sessenta e três indivíduos atuaram como avaliadores em 2012.
A probabilidade de negociação com informação privilegiada no mercado acionário brasileiro
Authors: Martins Orleans Silva , Paulo Edilson
Published: October 2019

Este artigo teve o objetivo de investigar a assimetria de informação existente na negociação de ações no mercado acionário brasileiro. Para isso, foi estimada a probabilidade de negociação com informação privilegiada (PIN) de 229 ações durante os anos de 2010 e 2011, por meio do modelo de Easley et al. (2002). Nos resultados, verificou-se que a PIN média dessas ações foi de 24,9%, o que sugere a existência de negociação informada nesse período. Considerando o segmento de governança corporativa, as ações listadas no Nível 2 apresentaram a menor PIN média (24,4%), enquanto as ações do Nível 1 a maior média (25,6%). Considerando as classes de ação, a PIN média das ON foi 24,2% e das PN foi 26,0%, indicando que ações com direito de voto apresentaram menor assimetria de informação. Ainda, verificou-se que a relação entre maior liquidez e menor PIN só foi confirmada para ações ON de alta liquidez.
Rating de Crédito e Estrutura de Capital: Evidências da América Latina
Authors: Rogers Dany , Mendes-da-Silva Wesley , Neder Henrique Dantas , Silva Pablo Rogers
Published: October 2019

O objetivo deste artigo é analisar o impacto das tendências de reclassificações no rating de crédito nas decisões de estrutura de capital de empresas não-financeiras listadas da América Latina. Para tanto foram empregados dados pertencentes a todas as empresas não-financeiras listadas da América Latina, possuidoras de ratings emitidos pelas três principais agências internacionais de rating (i.e. Standard & Poor´s, Moody´s e Fitch) em janeiro de 2010. Ao considerar dados relativos ao período 2001-2010, por meio de análise de dados em painel, os principais resultados obtidos sugerem que as reclassificações dos ratings parecem não possuir conteúdo informacional para as decisões de estrutura de capital das empresas. Porém, alguns resultados indicam que as empresas classificadas em níveis piores de risco, e que se encontrem na iminência de reclassificações do rating, tendem a usar mais dívidas do que as outras empresas, sugerindo existência de market timing.
Searching for the Reference Point
Authors: Baillon Aurélien , Bleichrodt Han , Spinu Vitalie
Published: October 2019

Although reference dependence plays a central role in explaining behavior, little is known about the way that reference points are selected. This paper identifies empirically which reference point people use in decision under risk. We assume a comprehensive reference-dependent model that nests the main reference-dependent theories, including prospect theory, and that allows for isolating the reference point rule from other behavioral parameters. Our experiment involved high stakes with payoffs up to a week’s salary. We used an optimal design to select the choices in the experiment and Bayesian hierarchical modeling for estimation. The most common reference points were the status quo and a security level (the maximum of the minimal outcomes of the prospects in a choice). We found little support for the use of expectations-based reference points.

This paper was accepted by David Simchi-Levi, decision analysis.
“AQUI É O LUGAR QUE A GENTE VIVE!” AS BRINCADEIRAS DAS CRIANÇAS DE UM QUILOMBO CATARINENSE
Authors: Paula Elaine De
Published: October 2019

Este texto contempla reflexões sobre as incursões que fiz em dois quilombos catarinenses como parte de minha pesquisa de doutorado em educação. A motivação central foi a de compreender e analisar, por meio de um estudo etnográfico, o lugar que as crianças quilombolas ocupam, como são suas práticas e experiências, e o que elas ‘expressam’ sobre as relações educativas que se estabelecem no espaço institucionalizado da educação infantil e no espaço da comunidade quilombola onde moram. A perspectiva teórica direcionou-se para uma interlocução entre os campos da Pedagogia, Sociologia da Infância e Antropologia. Embora a pesquisa ter se dado também na educação infantil, abarco, todavia, neste texto observações a partir dos lugares e dos tempos ocupados pelas crianças nos quilombos, em especial aludindo a seus diferentes jeitos de ser, de se expressar nos momentos de brincar. A pesquisa evidencia um alto grau de cumplicidade, autonomia e criação de brincadeiras entre as crianças nos quilombos e demostra que suas formas de expressão ou de sociabilidade podem suscitar outras maneiras de pensar a educação institucionalizada.
EDUCAÇÃO FÍSICA E LINGUAGEM: APROXIMAÇÕES COM A HERMENÊUTICA GADAMERIANA
Authors: Almeida Luciano , Fensterseifer Paulo Evaldo
Published: October 2019

O presente artigo tem por objetivo construir um aporte teórico capaz de nos dar indicativos para redimensionar o hiato existente entre o fazer (prático), o saber com esse fazer (teórico) e as dimensões estéticas (subjetivas) e éticas (intersubjetivas) na Educação Física (escolar). Para isso, este estudo de base bibliográfica busca, na obra de Hans-Georg Gadamer (em especial na obra Verdade e Método), e em seus comentadores, justificar nossa tarefa educativa, a partir da nossa relação com a cultura corporal de movimento para além de uma racionalidade científica-instrumental. O reconhecimento do se-movimentar como fenômeno da linguagem permite-nos lançar um olhar mais alargado para as dimensões do conhecimento em nosso campo de tematização; por outro lado, indica a necessidade de um diálogo mais aprofundado entre as noções de linguagem e experiência, uma vez que estas não podem ser vistas como dois polos opostos, mas como condição (complementar) de nossa compreensão de mundo.
Islambekov R. K. (on the occasion of his 75-th birthday)
Authors: Journal Staff Problems of Endocrinology
Published: October 2019

The article is devoted to the 75th anniversary of the famous endocrinologist, consultant of the Endocrinological research center of the RAMS, corresponding member of the Russian Academy of Medical Sciences, Lenin Prize Laureate, honored worker of science of the Republic of Uzbekistan, doctor of Medical Sciences, Professor Rajab Kaplanovich Islambekov.
Analysis of hypothalamo-hypophyseo-gonadal relationships in female rats with experimental diabetes
Authors: Babichev V N , Adamskaya Ye L , Peryshkova T A
Published: October 2019

Hypothalamo-hypophyseo-gonadal system functional activity was studied in rats with streptozotocin diabetes. In intact rats concentrations of sex hormones nuclear receptors were measured in the hypothalamic preopticoanterior, mediobasal segments and in the adenohypophysis, as were blood serum gonadotropins and sex hormones. Estradiol and progesterone were injected to ovariectomized females and LH-RH levels measured in preopticoanterior segment of the hypothalamus, arcuate nucleus, and median eminence, as well as LH and FSH concentrations in the blood in order to detect disorders in basal and cyclic gonadotropin secretion. Streptozotocin injection to cycling females disordered the estral cycle and was associated with reduction of LH, FSH, and sex hormones basal and cyclic secretion. Estradiol nuclear receptors concentrations reduced in the preopticoanterior hypothalamus and hypophysis, the count of nuclear testosterone-binding sites reduced only in the hypophysis. Gonadotropin wave stimulated with sex steroids in ovariectomized females was reduced in diabetes because of changed activity of LH-RH-producing system. We believe that changes in basal and cyclic secretion of gonadotropins in rat females with experimental diabetes is explained by reduced activity of LH-RH-producing system and receptor binding at the level of the hypothalamo-hypophyseal complex.
Energy expenditures of outpatients and inpatients with insulin-dependent diabetes: A computer analysis
Authors: Dreval A V , Anykina N V , Nefyodova G A , Tishin D P , Zubenko A D , Proshina I V
Published: October 2019

Original computer programs for assessment of energetic value of nutrition and daily energy expenditures of man based on physical activity protocols have been developed. The programs were tried in 16 patients with insulin-dependent diabetes, and essential individual differences from tentative table estimations of energy expenditures were detected. Correlations between treatment efficacy and individual energy expenditures of patients were observed; a moderate deficit of nutrition calories was found more detrimental for metabolic control than their moderate excess. The regularities detected even in such a nonrepresentative sample permit us evaluate high the potentialities and significance of the suggested method for assessment of energy expenditures.
Cardiodynamics in diabetes mellitus
Authors: Zhuplatov S. В. , Trusov V. V.
Published: October 2019

Ninety six patients with diabetes mellitus were examined, 37 of these were included in group 1, the rest ones in whom diabetes was combined with coronary disease were included in group 2. Echocardiography revealed appreciable deceleration of the relaxation of the posterior wall of the myocardium in both groups. All patients presented with a reduced index of myocardial viability — by 32 and 58.6%, respectively. Besides disturbed diastolic function, group 2 patients developed deterioration of the systolic function of the myocardium.
Fertility of women with insulin-dependent diabetes mellitus
Authors: Dedov I. I. , Melnichenko G. A. , Berdyklycheva A. A.
Published: October 2019

Fertility of women suffering from insulin-dependent diabetes mellitus (IDDM) and outcomes of pregnancy in them were analyzed on the basis of case histories of 279 women aged over 25 administered traditional nonintensified insulin therapy. No appreciable differences in the fertility of these women in comparison with that in the general population were revealed. The possibility of conception is increased if IDDM manifests after menarche and maturation of the sexual function. Fertility was the lowest in diabetic women in whom the disease manifested before the age of 10 years. Induced abortions were the most frequent outcomes of pregnancy in diabetic women. The incidence of spontaneous abortions in diabetic women was virtually the same as in the population at large. The incidence of stillbirths is evidently increased in comparison with that in the general population.
The hormonal function of human gonads and adrenals at various age
Authors: Goncharov N. P. , Katsiya G. V.
Published: October 2019

Results of radioimmunoassay of the adrenal and sex hormones and their precursors in the peripheral blood of men of different age groups are presented. The measurements were carried out in men of mature age of the two periods (22 to 35 years of age. I period, and 36 to 60. II period), elderly subjects aged 61 to 74, senile ones aged 75 to 90, and in long-livers aged 91 to 112. The content of the principal adaptive hormone, hydrocortisone, and its immediate precursor 11-deoxyhydrocortisone was found to be virtually the same in all age groups. At the same time, the levels of other precursors – pregnanediole, 17-hydroxypregnanediole and 17-hydroxyprogesterone progressively reduce with age. An inverse correlation can be traced between the level of the principal adrenal androgen, dehydroepiandrosterone, and the age of the examined men. In contrast to testosterone, the content of 5alfa-dehydrotestosterone is reliably reduced in elderly age and remains at this level in the subsequent years.
A modified radioimmunoassay of aldosterone
Authors: Goncharov N. P. , Katsiya G. V. , Butnev V. Yu. , Khagundokova L. B.
Published: October 2019

A method of radioimmunoassay of aldosterone in the blood of humans and monkeys has been developed. Antiserum was prepared on rabbits against aldosterone-3-(0-carboxymethyloxime) conjugate with bovine serum albumin. The specificity of antiserum was tested in cross-reactions with 32 related steroids. High specificity of the antiserum in this method helped measure aldosterone levels without preliminary chromatographic isolation and purification of this compound. The sensitivity of the new method is 12.5 pg per 0.1 ml. Reproducibility of the method between different series of measurements was no more than 15%, within the same series below 12%. The method was used to assess the mineralocorticoid function of the adrenal cortex of man and monkeys.
Mikhail Ivanovich Balabolkin (To his 60th birthday)
Authors: Problems of endocrinology Editorial team of
Published: October 2019

60 years have passed since the birth of the famous scientist endocrinologist, director of the Research Institute of Diabetes of the Endocrinological Research Center of the Russian Academy of Medical Sciences, doctor of medical sciences, professor Mikhail Ivanovich Balabolkin. A large place in the studies of M.I. Balabolkin is occupied by the issues of diagnosis and treatment of pituitary adenomas, autoimmune diseases of the thyroid gland, and more recently, the problem of the pathogenesis and treatment of diabetes mellitus and its late complications. M. I. Balabolkin published 350 scientific works, including 10 monographs. He is the author of a textbook on endocrinology for medical schools.
Clinical syndromes associated with the shox gene
Authors: Vitebskaya A. V.
Published: October 2019

Growth is a complex process, which is influenced by a huge number of factors at all stages of development starting from the prenatal. Up to 3% of the population suffers from stunting, caused by various reasons. When examining patients with growth retardation, differential diagnosis is usually carried out between pituitary dwarfism, hypothyroidism, systemic diseases, chromosomal disorders, various forms of chondrodysplasias, psychosocial disorders and idiopathic growth retardation, the frequency of which among all forms of short stature heights reaches 80%
Components of the hamkergic system and its function in the endocrine glands
Authors: Mishunina T. M.
Published: October 2019

In the first years after the discovery in the brain of vertebrates of gamma-aminobutyric acid (GABA), which was later recognized as the main inhibitory mediator of the central nervous system, it was believed that it was localized exclusively in the cells of the nervous system. An increase in the sensitivity of GABA determination methods allowed later to establish the presence of amino acids, enzymes of its metabolism, transport systems, as well as receptors in cells of other tissues and organs. The mechanism of action of GABA on the periphery is mediated by both membrane receptors (in the case of transmission of a nerve impulse or trophic effect), and without their participation (in the regulation of intracellular processes)
On the history of the study of goiter in the Far East
Authors: Zakharenko R. V. , Sirotin B. Z.
Published: October 2019

The problem of iodine deficiency and related diseases in Russia remains relevant and has not yet been resolved. The main manifestation of iodine deficiency, as a rule, is goiter, although the spectrum of diseases caused by insufficient intake of iodine is very wide and includes violations of human somatic, mental and reproductive health
Genetic markers of diffuse toxic goiter
Authors: Chistyakov D. A. , Savostyanov К. V.
Published: October 2019

The article is devoted to the review of genetic markers of diffuse toxic goiter (graves' disease).
Diagnosis, strategy, and surgical treatment of patients with multinodular euthyroid goiter
Authors: Voskoboinikov V. V. , Vanushko V. E. , Artemova A. M. , Soldatova T. V. , Kuznetsov N. S.
Published: October 2019

The article is devoted to the review of the Diagnosis, strategy, and surgical treatment of patients with multinodular euthyroid goiter.
Assessment of improving the quality of life of patients with metabolic syndrome
Authors: Antyuf"ev V. F. , Kodolova Yu. V.
Published: October 2019

The stationary technique for examining and treating patients with the metabolic syndrome who had vascular diseases of the heart and brain was tested in the regional rehabilitative center "Ozero Chusovskoye" (Chusovsk Lake), Yekaterinburg. The purpose of the study was to examine the pattern of metabolic and cardiovascular disorders in relation to the severity of obesity and to assess the results of their correction 6 months after the initiation of adequately chosen therapy. The results of 6-month multimodality treatment for the metabolic syndrome, which involved both drug and non-drug methods, such as reduction in body weight and its index by 8.5 and 19.86%, respectively, in the proportion offat in the body by 9%, a significant decrease in the blood level of sugar 2 hours after load, hepatic transaminases, uric acid are presented. A significant relationship was found between the degree of obesity and the severity of cardiovascular and metabolic disorders.
Obstructive sleep apnea syndrome and endocrine disorders
Authors: Yeroshina V. A. , Gasilin V. S. , Buzunov R. V.
Published: October 2019

The article is devoted to the peculiarities of the obstructive sleep apnea syndrome and endocrine disorders.
Urokinase and tissue plasminogen activators and their inhibitor for thyroid diseases
Authors: Kushlinskii N. E. , Kazantseva I. A. , Gershtein E. S. , Kharitidi T. Yu. , Lyakina L. T.
Published: October 2019

The results of a comparative study of the level of the components of the plasminogen activation system - и Pa, tPA, and PAI-1 in the tissues of cancer and benign masses of the thyroid are presented. Nineteen patients with nodal colloidal goiter (NCG) with adeno­matosis, 43 patients with NCG without adenomatosis, 9patients with diffuse toxic goiter (DTG) with adenomatosis, 13 patients without adenomatosis, 18 patients with thyroid adenoma (TA), and 44 patients with thyroid cancer (TC) were examined. The concentrations of the studied proteins were determined by enzyme immunoassay in tissue cytosols. The lowest levels of tPA and the highest values of и PA and PAI-1 were found in the tumors of patients with TC whereas the high values of tPA and the relatively low levels of и PA were typical of benign thyroid hyperplasias and TA. The lowest levels of PAI-1 were detected in patients both with and without DTG. The tissue level of the components of the plasminogen activation system in TC did not virtually depend on the histological features of a tumor, but it significantly correlated with the extent of a process.
Diagnosis of primary hyperaldosteronism
Authors: Pavlenko A. K. , Fadeev V. V. , Melnichenko G. A.
Published: October 2019

The article is devoted to the review of the peculiarities of primary hyperaldosteronism.
Comparative study of the effects of thyroxin and cytoplasmic thyroxin-binding protein on the synthesis of mitochondrial proteins of the liver and brain in rats of different age
Authors: Turakulov Ya. Kh. , Dalimova S. N. , Kamaliyeva I. R.
Published: October 2019

Study of the time course of protein synthesis by intact liver and brain mitochondria in rats of different age exposed to thyroxin in physiological concentrations (10-8 M) and cytoplasmic thyroxin-binding protein (modulator of thyroxin effect — MDT4) showed that thyroxin did not influence protein synthesis in liver and brain mitochondria. On the other hand, MDT4 stimulated protein synthesis, this stimulation correlating with the age of rats. In brain cells MDT4 enhanced labeled leucin incorporation in the embryonal and early postnatal periods. MDT4 is proposed to be involved in the mechanism of tissue-specific effect of thyroxin and in the formation of age-specific sensitivity to it.
Epidemiology of diabetes mellitus
Authors: Pankiv V. I.
Published: October 2019

Diabetes mellitus (DM) is one of the most common diseases, the frequency of which is steadily increasing every year. In industrialized countries, the prevalence of DM is 4-5%. Despite the large number of existing forms of diabetes associated with various syndromes and diseases, the main ones are two that are characterized as spontaneous: insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes (NIDDM). Statistical data on the prevalence of the disease are based on the registration of a medical diagnosis of diabetes and in general reflect mainly the prevalence of spontaneous forms of IDDM and NIDDM. In 1991, 1 826 758 patients with DM were registered in the Russian Federation, of which 295 333 (16.2%) suffered from IDDM. Compared with 1990, the number of patients with diabetes increased by 5.78%. However, the figures do not reflect the actual prevalence of diabetes. The conducted epidemiological studies on the frequency of diabetes show that the true number of patients with diabetes is 3-4 times higher compared to the registered one. These include people with a mild form of NIDDM who do not need medical treatment, as well as people with impaired glucose tolerance. In these groups, disorders of carbohydrate metabolism occur in a subclinical form, and the recorded prevalence of diabetes is largely determined by the quality of the medical examination. A more accurate picture of the prevalence of various types of diabetes can be obtained only with the State Register for diabetes, its development is necessary in the near future.
In memory to Ye. V. Naumenko
Authors: Problems of endocrinology Editorial team of
Published: October 2019

On November 13, 1994, science suffered a heavy loss - an outstanding Russian scientist, professor, doctor of medical sciences, the founder of a number of original directions in world neuroendocrinology Evgeny Vladimirovich Naumenko prematurely passed away. In the 60s, the scientific interests of E.V. Naumenko were focused on studying the role of biogenic brain amines in the neurochemical regulation of the hypothalamic-pituitary-adrenocortical system. In particular, he proved for the first time that one of the final hypothalamic neural pathways stimulating the synthesis and secretion of corticoliberin is serotonergic in nature. The results of these widely known studies at home and abroad brought well-deserved fame to a neuroendocrinologist from Siberia. In the last 20 years, the main work of E.V. Naumenko concerned the study of genetic evolutionary and ontogenetic aspects of stress, the role of neuroendocrine mechanisms in animal domestication processes, the role of neurochemical brain mechanisms in the dominant behavior of individuals in micropopulations, and the study of a new model of hereditary arterial hypertension. Professor E.V. Naumenko has published over 300 works, including more than a dozen major monographic publications published at home and abroad. These publications are widely known among specialists, they have made a significant contribution to the development of neuroendocrinology and brought well-deserved recognition to their author.
Tromethamol salt of thioctic (alpha-lipoic) acid in the treatment of diabetic neuropathy
Authors: Severina T. I. , Tarasov A. V. , Trelskaya N. Yu. , Shilova O. L. , Drometr D. A.
Published: October 2019

Thioctic acid tromethamol salt (thioctacide 600, ASTA Medica, Germany) was used in the treatment of 20 diabetics with type 1 disease with pronounced diabetic neuropathy (DN). The drug was injected intravenously by drip infusion in 200 ml 0.9% sodium chloride for 3 weeks (5 times a week with 2-day intervals), after which it was given orally, I tablet 30 min before breakfast for 4-8 weeks. After the course essential improvement was observed in all the patients. According to the questionnaires, pain decreased by 64%, and according to DN score 2.3 times. Elec-troneuromyographic parameters improved significantly, cardiac rhythm variability increased in 67% patients with stable heartbeat. In the placebo group 50% patients noted improvement, but it was far less expressed. Hence, the study demonstrated a high efficiency of thioctacide in the treatment of patients with DN.
Pathogenetic role of diabetic microangiopathy in development of the diabetic foot syndrome
Authors: Udovichenko О. V. , Antsiferov M. B. , Tokmakova A. Yu.
Published: October 2019

The article is devoted to the review of the pathogenetic role of diabetic microangiopathy in development of the diabetic foot syndrome.
O Programa Nacional Escola de Gestores:
Authors: Souza Raquel Aparecida , Moraes Raquel de Almeida
Published: October 2019

O estudo teve como objeto a formação de professores/gestores no âmbito do Programa Escola de Gestores a partir do curso de especialização em coordenação pedagógica. Buscou compreender se os objetivos propostos nos documentos oficiais a respeito da formação desenvolvida na modalidade da educação a distância foram alcançados. Foi realizada pesquisa bibliográfica e documental, complementada por questionários. As análises pautaram-se em uma lógica buscando um movimento a partir do materialismo histórico dialético. A comparação entre os sentidos explícitos e implícitos revelaram contradições, o que sinaliza a necessidade de fazer um caminho mais profundo em busca das explicações desse programa.
Das expectativas aos direitos de aprendizagem:
Authors: Destro Denise de Souza , Santos Geniana dos , Oliveira Ozerina Victor de
Published: October 2019

Este trabalho apresenta reflexões sobre a expressão “direitos de aprendizagens” orientadora de práticas discursivas no contexto das reformas curriculares contemporâneas. Objetiva problematizar o processo de articulação que provoca a flutuação de sentidos na trajetória de construção de tais direitos (2012 - 2017) a partir dos documentos: Definição das Expectativas de Aprendizagem; Elementos Conceituais e Metodológicos para Definição dos Direitos de Aprendizagem e Desenvolvimento do Ciclo de Alfabetização e a Resolução CNE/CP Nº 2, de 22 de Dezembro de 2017. Utilizamos a Teoria do Discurso de Ernesto Laclau e pela perspectiva discursiva proposta por Alice Lopes, como arcabouço teórico. Como resultados, salientamos o deslizamento de significação entre os anos de 2011 e 2017, iniciado com documento vinculado ao movimento Todos pela Educação e normatizado pela BNCC. As intenções formativas apresentadas inicialmente deslizaram de sentido para intenções educativas pautadas por habilidades e competências, ressignificando a função da escola e sua articulação com as demandas sociais.
Heterogeneous primaries in CR4BP
Authors: A. Ansari Abdullah , Ali Ashraf , Shalini Kumari , Alam Mehtab
Published: October 2019

This paper investigates the motion of the massless body moving under the influence of the gravitational forces of the three equal heterogeneous oblate spheroids placed at Lagrangian configuration. After determining the equations of motion and the Jacobian constant of the massless body, we have illustrated the numerical work (Stationary points, zero-velocity curves, regions of motion, Poincare surfaces of section and basins of attraction). And then we have checked the linear stability of the stationary points and found that all the stationary points are unstable.Â