bluuebunny/crossref_metadata_2025 huggingface dataset:
Growth, Properties, and Theoretical Analysis of M2LiVO4 (M = Rb, Cs) Crystals: Two Potential Mid-Infrared Nonlinear Optical Materials
Authors: Han Guopeng , Wang Ying , Su Xin , Yang Zhihua , Pan Shilie
Published: May 2017

Mid-Infrared nonlinear optical (Mid-IR NLO) crystals with excellent performances play a particularly important role for applications in areas such as telecommunications, laser guidance, and explosives detection. However, the design and growth of high performance Mid-IR NLO crystals with large NLO efficiency and high laser-damage threshold (LDT) still face numerous fundamental challenge. In this study, two potential Mid-IR NLO materials, Rb2LiVO4 (RLVO) and Cs2LiVO4 (CLVO) with noncentrosymmetric structures (Orthorhombic, Cmc21) were synthesized by high-temperature solution method. Thermal analysis and powder X-ray diffraction demonstrate that RLVO and CLVO melt congruently. Centimeter sized crystals of CLVO have been grown by the top-seeded solution growth method. RLVO and CLVO exhibit strong second harmonic generation (SHG) effects (about 4 and 5 times that of KH2PO4, respectively) with a phase-matching behavior at 1.064 μm, and a wide transparency range (0.33–6.0 μm for CLVO). More importantly, RLVO and CLVO possess a high LDT value (~28 × AgGaS2). In addition, the density functional theory (DFT) and dipole moments studies indicate that the VO4 anionic groups have a dominant contribution to the SHG effects in RLVO and CLVO. These results suggest that the title compounds are promising NLO candidate crystals applied in the Mid-IR region.
Flexible Two-Photon Interference Fringes with Thermal Light
Authors: Cao De-Zhong , Ren Cheng , Ni Jin-Yang , Zhang Yan , Zhang Su-Heng , Wang Kaige
Published: May 2017

Flexible interference patterning is an important tool for adaptable measurement precisions. We report on experimental results of controllable two-photon interference fringes with thermal light in an incoherent rotational shearing interferometer. The two incoherent beams in the interferometer are orthogonally polarized, and their wavefront distributions differ only in an angle of rotation. The spacings and directions of the two-photon interference fringes vary with the rotation angle, as illustrated in three cases of two-photon correlation measurements in experiment.
The Fatty Acid β-Oxidation Pathway is Activated by Leucine Deprivation in HepG2 Cells: A Comparative Proteomics Study
Authors: Yan Guokai , Li Xiuzhi , Peng Ying , Long Baisheng , Fan Qiwen , Wang Zhichang , Shi Min , Xie Chunlin , Zhao Li , Yan Xianghua
Published: May 2017

Leucine (Leu) is a multifunctional essential amino acid that plays crucial role in various cellular processes. However, the integral effect of Leu on the hepatic proteome remains largely unknown. Here, we for the first time applied an isobaric tags for relative and absolute quantification (iTRAQ)-based comparative proteomics strategy to investigate the proteome alteration induced by Leu deprivation in human hepatocellular carcinoma (HepG2) cells. A total of 4,111 proteins were quantified; 43 proteins were further identified as differentially expressed proteins between the normal and Leu deprivation groups. Bioinformatics analysis showed that the differentially expressed proteins were involved in various metabolic processes, including amino acid and lipid metabolism, as well as degradation of ethanol. Interestingly, several proteins involved in the fatty acid β-oxidation pathway, including ACSL1, ACADS, and ACOX1, were up-regulated by Leu deprivation. In addition, Leu deprivation led to the reduction of cellular triglycerides in HepG2 cells. These results reveal that the fatty acid β-oxidation pathway is activated by Leu deprivation in HepG2 cells, and provide new insights into the regulatory function of Leu in multiple cellular processes, especially fatty acid metabolism.
Tunability of Band Gap and Photoluminescence in CH3NH3PbI3 Films by Anodized Aluminum Oxide Templates
Authors: Zhang Zhan , Wang Min , Ren Lixia , Jin Kexin
Published: May 2017

Hybrid organic-inorganic halide CH3NH3PbI3 perovskite films are deposited on anodized aluminum oxide templates with the different pore diameters via one-step spin coating method. The obvious 0.082 eV blue shift of optical band gap is observed in films with decreasing the diameters of pores from 400 to 30 nm. And numerical simulations based on finite element modeling are carried out to represent the absorption edge and consistent with the experiment results. It is interesting that the films show the intense photoluminescence with the excitation intensity of less than 1 μW. Moreover, the photoluminescence intensity is increased with increasing pore diameters, which is attributed to the radiative recombination rate of photogenerated electrons and holes. These results pave a way for the further understanding of tunable photophysical properties of perovskite films.
Combined Therapy with Shock Wave and Retrograde Bone Marrow-Derived Cell Transplantation for Osteochondral Lesions of the Talus
Authors: Gao Fuqiang , Chen Na , Sun Wei , Wang Bailiang , Shi Zhencai , Cheng Liming , Li Zirong , Guo Wanshou
Published: May 2017

Multiple treatment strategies have been developed for osteochondral lesions (OCLs) of the talus. The purpose of this retrospective study was to assess retrograde autologous bone marrow cell (BMC) transplantation via core drilling (CD) combined with focused extracorporeal shock wave treatment (ESWT) in undisplaced OCL of the talus. A total of 69 patients with unilateral osteochondral lesions of the talus (Hepple grade I–III) were divided into two groups: 41 patients received combined therapy of ESWT and BMC transplantation (group A), while 28 were administered BMC transplantation alone (group B). The patients were followed up clinically and radiographically for a minimum of 2 years. Mean follow-up was 4.1 ± 2.8 years. AOFAS scores increased more significantly while pain intensity levels decreased in group A after treatment, compared with group B values (P < 0.001). In MRI follow-up, a more remarkable improvement of OCLs of the talus was observed in group A compared with group B (P = 0.040). Therefore, the combined technique reported here is a highly effective therapeutic option in OCLs of the talus with intact cartilage. It promotes patient recovery with pain control, and improves clinical outcome for more than 2 years after surgery.
Erratum: T1-weighted in vivo human whole brain MRI dataset with an ultrahigh isotropic resolution of 250 μm
Authors: Lüsebrink Falk , Sciarra Alessandro , Mattern Hendrik , Yakupov Renat , Speck Oliver
Published: May 2017

Scientific Data 4:170032 doi: 10.1038/sdata.2017.32 (2017); Published 14 March 2017; Updated 9 May 2017 The original HTML version of this Data Descriptor incorrectly included Oliver Speck’s name in the Data Citations as ‘Speck, C.’ instead of ‘Speck, O.’ This has now been corrected in the HTML version.
A missense variant of the ABCC11 gene is associated with Axillary Osmidrosis susceptibility and clinical phenotypes in the Chinese Han Population
Authors: Ren Yunqing , Liu Wenting , Chen Jisu , Wang Jianyou , Wang Ke , Zhou Jiong , Cai Suiqing , Zheng Min , Liu Jianjun , Liu Lunfei , Xue Dan
Published: May 2017

Axillary osmidrosis (AO) is a common condition characterized by an offensive odor arising from apocrine gland secretions in the axillae that socially and psychologically impairs affected individuals. The exact aetiology of AO is still not fully understood, but genetic factors have been suggested to play an important role. Recently, a single nucleotide polymorphism (SNP) rs17822931 in the ABCC11 gene located on human chromosome 16q12.1 has been shown to be associated with AO. In this study, we genotyped rs17822931 in two independent samples of Chinese Hans including 93 AO individuals vs 95 controls and 81 AO individuals vs 106 controls by using SNaPshot Multiplex Kit. We confirmed the association for ABCC11 gene, showing that rs17822931-G was significantly associated with increased risk for AO (Pcombined = 1.42E-21, OR = 83.94, 95% CI = 83.03–84.85). We also found rs17822931 was associated with subphenotypes of AO. AO individuals carrying the risk allele G are more likely to show wet earwax (P = 2.40E-05), higher frequency of family history (P = 1.04E-02) and early age of onset (P = 3.81E-02). Our study concluded that the association of rs17822931 in the ABCC11 gene with AO was replicated in Chinese Han population.
Correction: Corrigendum: Crystal structures of highly simplified BPTIs provide insights into hydration-driven increase of unfolding enthalpy
Authors: Monirul Islam Mohammad , Yohda Masafumi , Kidokoro Shun-ichi , Kuroda Yutaka
Published: May 2017

Scientific Reports 7: Article number: 41205; published online: 07 March 2017; updated: 09 May 2017 This Article contains errors in the Data Availability section, “The coordinates and structure factors of BPTI-21A, BPTI-22Ab, BPTI-23A and BPTI-24A variants are deposited in the Protein Data Bank underthe PDB entry codes 4YPK, 4YPP, 4YR4 and 4YR5, respectively and we previously reported the structures of BPTI-19A (3AUB) and BPTI-20A (3CI7)”.
Erratum: Effects of bumetanide on neurobehavioral function in children and adolescents with autism spectrum disorders
Authors: Lemonnier E , Villeneuve N , Sonie S , Serret S , Rosier A , Roue M , Brosset P , Viellard M , Bernoux D , Rondeau S , Thummler S , Ravel D , Ben-Ari Y
Published: May 2017

Correction to: Translational Psychiatry (2017) 7, e1056; doi:10.1038/tp.2017.10; published online 14 March 2017 The ninth author’s affiliation was presented incorrectly in the published paper. Additionally, only the first affiliation should have included CHU Hôpital Le Cluzeau. The correct affiliations appear below:
Target-induced duplex–triplex transition for ratiometric detection of adenosine triphosphate
Authors: Yao Shujuan , Gao Yanhua , Wang Wen , Ni Donghua , Zhang Kaixian , Li Ling , Du Jianqiang , Cui Xiujuan
Published: May 2017

Target-induced duplex–triplex transition for ratiometric aptamer sensor.
A pencil drawn microelectrode on paper and its application in two-electrode electrochemical sensors
Authors: Jomma Ezzaldeen Younes , Bao Ning , Ding Shou-Nian
Published: May 2017

A pencil drawn microelectrode on paper and its application in two-electrode electrochemistry.
Relativistic effects in metallocorroles: comparison of molybdenum and tungsten biscorroles
Authors: Alemayehu Abraham B. , Vazquez-Lima Hugo , McCormick Laura J. , Ghosh Abhik
Published: May 2017

The homoleptic sandwich compounds – Mo and W biscorroles – showcase strong relativistic effects on redox potentials and optical spectra.
A dynamic kinetic asymmetric transfer hydrogenation–cyclization tandem reaction: an easy access to chiral 3,4-dihydro-2H-pyran-carbonitriles
Authors: Zheng Dongsong , Zhao Qiankun , Hu Xiaoying , Cheng Tanyu , Liu Guohua , Wang Wei
Published: May 2017

A catalytic enantioselective dynamic kinetic asymmetric transfer hydrogenation–cyclization tandem reaction is developed for 1,3-difunctionalized racemic ketones.
Rhodium-catalyzed synthesis of 1,2-dihydropyridine by a tandem reaction of 4-(1-acetoxyallyl)-1-sulfonyl-1,2,3-triazole
Authors: Dai Haican , Yu Sisi , Cheng Wanli , Xu Ze-Feng , Li Chuan-Ying
Published: May 2017

A tandem reaction of 4-(1-acetoxyallyl)-1-sulfonyl-1,2,3-triazole involving α-imino rhodium carbene was reported and 1,6-dihydropyridin-3-yl acetate was obtained.
Generating single metalloprotein crystals in well-defined redox states: electrochemical control combined with infrared imaging of a NiFe hydrogenase crystal
Authors: Ash P. A. , Carr S. B. , Reeve H. A. , Skorupskaitė A. , Rowbotham J. S. , Shutt R. , Frogley M. D. , Evans R. M. , Cinque G. , Armstrong F. A. , Vincent K. A.
Published: May 2017

We manipulate and verify the redox state of single metalloprotein crystals by combining electrochemical control with synchrotron infrared microspectroscopy.
Development of Ir and La-codoped BaTa2O6 photocatalysts using visible light up to 640 nm as an H2-evolving photocatalyst for Z-schematic water splitting
Authors: Iwase Akihide , Kudo Akihiko
Published: May 2017

A novel Z-scheme system was constructed using a newly developed Ir and La-codoped BaTa2O6 photocatalyst for H2 evolution.
Strong chiroptical activity from achiral gold nanorods assembled with proteins
Authors: Shinmori Hideyuki , Mochizuki Chihiro
Published: May 2017

The optical activity of side-by-side gold nanorod assembly induced by interaction with proteins has the highest anisotropy factor in colloidal solution.
Rapid synthesis of CuInTe2 ultrathin nanoplates with enhanced photoelectrochemical properties
Authors: Zhang Xiao , Yang Lei , Guo Zenglong , Su Ge , Gao Rongjie , Wang Wei , Dong Bohua , Cao Lixin
Published: May 2017

Ultrathin (2.1 ± 0.1 nm) single-crystal CuInTe2 two-dimensional (2D) nanoplates were synthesized via a rapid colloidal synthesis method.
Complex magnetic orders in small cobalt–benzene molecules
Authors: González J. W. , Alonso-Lanza T. , Delgado F. , Aguilera-Granja F. , Ayuela A.
Published: May 2017

Organometallic clusters based on transition metal atoms are interesting because of their possible applications in spintronics and quantum information processing.
The role of group III, IV elements in Nb4AC3MAX phases (A = Al, Si, Ga, Ge) and the unusual anisotropic behavior of the electronic and optical properties
Authors: Fu Yu-dong , Wang Baochang , Teng Yue , Zhu Xiao-shuo , Feng Xiao-xue , Yan Mu-fu , Korzhavyi Pavel , Sun Weiwei
Published: May 2017

The nesting Fermi surface of Nb4SiC3with an unconventional anisotropy.
Microstructure degradation of Ni/CGO anodes for solid oxide fuel cells after long operation time using 3D reconstructions by FIB tomography
Authors: Zekri Atef , Knipper Martin , Parisi Jürgen , Plaggenborg Thorsten
Published: May 2017

The 3D reconstructions of SOFC anode microstructure aged up to 20 000 h under realistic conditions was carried out with FIB/SEM tomography in order to calculate the microstructure key parameters.
Effects of temperature, concentration, and isomer on the hydration structure in monosaccharide solutions
Authors: Tomobe Katsufumi , Yamamoto Eiji , Yasui Masato , Yasuoka Kenji
Published: May 2017

In this study, we elucidated the effects of temperature, concentration, and isomer on the hydration structure in monosaccharide solutions using molecular dynamics simulations.
Sb102−and Sb22−found in [K(18-crown-6)]6[Sb10] [Sb4{Mo(CO)3}2]·2en: two missing family members
Authors: Ruan Huapeng , Wang Lulu , Li Zhenyu , Xu Li
Published: May 2017

Two missing family members of antimony polyanions, Sb102−and Sb22−found in [K(18-crown-6)]6[Sb10][Sb4{Mo(CO)3}2]·2en have been obtained from the reaction of KMnSb and C7H8Mo(CO)3. Sb22−provides the second example of naked, doubly bonded diatomic anions following Bi22−and the first example of such doubly bonded anions stabilized by metal carbonyl groups.
Structural and electronic elucidation of a N-heterocyclic silylene vanadocene adduct
Authors: Hänninen Mikko M. , Baldansuren Amgalanbaatar , Pugh Thomas
Published: May 2017

The formation mechanism and bonding in a rare vanadocene complex with N-heterocyclic silylene (1,3-bis(2,6-diisopropylphenyl)-1,3-diaza-2-silacyclopent-4-en-2-ylidene) is elucidated using a combination of experimental and theoretical techniques.
Modulation of the FeII spin crossover effect in the pentadecanuclear {Fe9[M(CN)8]6} (M = Re, W) clusters by facial coordination of tridentate polyamine ligands
Authors: Chorazy Szymon , Stanek Jan J. , Kobylarczyk Jedrzej , Ohkoshi Shin-ichi , Sieklucka Barbara , Podgajny Robert
Published: May 2017

N,N,N-tridentate ligands coordinated to {Fe9[M(CN)8]6} (M = Re, W) induce the spin crossover on the external Fe sites of the cluster.
Effects of the ether oxygen atom in alkyl side chains on the physical properties of piperidinium ionic liquids
Authors: Nokami T. , Yamashita T. , Komura T. , Handa N. , Shimizu M. , Yamaguchi K. , Domi Y. , Usui H. , Sakaguchi H. , Itoh T.
Published: May 2017

Various types of piperidinium ionic liquids equipped with an oxygen atom-containing alkyl side chain on the positively charged nitrogen atom were systematically synthesized and their physical properties investigated.
Molecular dynamics of dilute binary chromonic liquid crystal mixtures
Authors: Matus Rivas Oscar M. , Rey Alejandro D.
Published: May 2017

The spontaneous aggregation of binary mixtures of lyotropic chromonic liquid crystals (LCLCs) was investigated using atomistic molecular dynamics simulations.
Highly selective ratiometric fluorescent probe based on diketopyrrolopyrrole for Au3+: an experimental and theoretical study
Authors: Yang Xiaofeng , Li Yexin , Zhao Zongshi , Ding Yiming , Zhang Yan , Liu Xiaolei , Cui Yu , Sun Guoxin , Zhang Guangyou , Yan Mei
Published: May 2017

A diketopyrrolopyrrole-based fluorescent probe 1 was explored as a ratiometric probe for selective detection of Au3+, with the detection limit of 18 nM.
Native and engineered sensors for Ca2+ and Zn2+: lessons from calmodulin and MTF1
Authors: Carpenter Margaret C. , Palmer Amy E.
Published: May 2017

Ca2+ and Zn2+ dynamics have been identified as important drivers of physiological processes. In order for these dynamics to encode function, the cell must have sensors that transduce changes in metal concentration to specific downstream actions. Here we compare and contrast the native metal sensors: calmodulin (CaM), the quintessential Ca2+ sensor and metal-responsive transcription factor 1 (MTF1), a candidate Zn2+ sensor. While CaM recognizes and modulates the activity of hundreds of proteins through allosteric interactions, MTF1 recognizes a single DNA motif that is distributed throughout the genome regulating the transcription of many target genes. We examine how the different inorganic chemistries of these two metal ions may shape these different mechanisms transducing metal ion concentration into changing physiologic activity. In addition to native metal sensors, scientists have engineered sensors to spy on the dynamic changes of metals in cells. The inorganic chemistry of the metals shapes the possibilities in the design strategies of engineered sensors. We examine how different strategies to tune the affinities of engineered sensors mirror the strategies nature developed to sense both Ca2+ and Zn2+ in cells.
Metallochaperones and metalloregulation in bacteria
Authors: Capdevila Daiana A. , Edmonds Katherine A. , Giedroc David P.
Published: May 2017

Bacterial transition metal homoeostasis or simply ‘metallostasis’ describes the process by which cells control the intracellular availability of functionally required metal cofactors, from manganese (Mn) to zinc (Zn), avoiding both metal deprivation and toxicity. Metallostasis is an emerging aspect of the vertebrate host–pathogen interface that is defined by a ‘tug-of-war’ for biologically essential metals and provides the motivation for much recent work in this area. The host employs a number of strategies to starve the microbial pathogen of essential metals, while for others attempts to limit bacterial infections by leveraging highly competitive metals. Bacteria must be capable of adapting to these efforts to remodel the transition metal landscape and employ highly specialized metal sensing transcriptional regulators, termed metalloregulatory proteins,and metallochaperones, that allocate metals to specific destinations, to mediate this adaptive response. In this essay, we discuss recent progress in our understanding of the structural mechanisms and metal specificity of this adaptive response, focusing on energy-requiring metallochaperones that play roles in the metallocofactor active site assembly in metalloenzymes and metallosensors, which govern the systems-level response to metal limitation and intoxication.
Quantum chemical approaches to [NiFe] hydrogenase
Authors: Vaissier Valerie , Van Voorhis Troy
Published: May 2017

The mechanism by which [NiFe] hydrogenase catalyses the oxidation of molecular hydrogen is a significant yet challenging topic in bioinorganic chemistry. With far-reaching applications in renewable energy and carbon mitigation, significant effort has been invested in the study of these complexes. In particular, computational approaches offer a unique perspective on how this enzyme functions at an electronic and atomistic level. In this article, we discuss state-of-the art quantum chemical methods and how they have helped deepen our comprehension of [NiFe] hydrogenase. We outline the key strategies that can be used to compute the (i) geometry, (ii) electronic structure, (iii) thermodynamics and (iv) kinetic properties associated with the enzymatic activity of [NiFe] hydrogenase and other bioinorganic complexes.
Beam combination scheme for multi‐user massive MIMO systems
Authors: Zhang Fangchao , Sun Shaohui , Gao Qiubin
Published: May 2017

Channel state information (CSI) at the base station (BS) is crucial to fully exploit the advantages of massive multiple‐input multiple‐output (MIMO) systems. In frequency division duplexing systems, CSI is obtained through downlink channel estimation and uplink CSI feedback. The conventional CSI acquisition scheme, which has been designed based on the beam selection principle, suffers from severe multi‐user interference when same beamforming vector is selected for different user equipments (UEs), and the spatial richness of the channel cannot be captured by the selected beamforming vector for the rich scattering environment. To address such issues, a beam combination scheme is proposed by combining multiple selected beamforming vectors for each UE, where the beam combination process is divided into wideband beam group construction and subband combination coefficients acquisition. Simulation results demonstrate that the proposed scheme could achieve considerable increase in the system throughput while maintaining acceptable feedback overhead.
Fast tracking of hidden objects with single‐pixel detectors
Authors: Chan S. , Warburton R.E. , Gariepy G. , Altmann Y. , McLaughlin S. , Leach J. , Faccio D.
Published: May 2017

A fast tracking system is demonstrated that is based on single laser illumination and a few single‐pixel single photon avalanche diode (SPAD) detectors that improves on the previous tracking of non‐line‐of‐sight motion by a factor of 300 in laser power. With an average illumination power of only 2 mW, a 15 cm ×15 cm object located up to 2.5 m away is tracked whilst outside of the direct line‐of‐sight and moving at approximately 6 cm/s.
Dynamic interference‐limited relay sharing in cognitive radio networks by using hierarchical modulation
Authors: Khakzad Hamidreza , Taherpour Abbas , Shakeri Reza , Khattab Tamer
Published: May 2017

Sharing a relay in cognitive radio (CR) networks in order to enhance the secondary user's (SU's) performance in an interference‐limited scheme is investigated. It is assumed, by utilising hierarchical modulation, a shared relay is used simultaneously between both primary user (PU) and SU. The proposed scheme relies on both power adaptation and rate scheduling. Based on channel side information and tolerable interference limitation at the PU, the SU adapts its power and the transmission data rates are regulated by the PU's status and channels condition. Theoretical analyses and simulation results are provided to evaluate the performance of the proposed dynamic spectrum sharing scheme. It is shown that rate adaptation leads to significant improvement of the throughput of the SU, at the cost of negligible degradation in performance of the PU. The results also demonstrate that sharing CR relay with the PU can compensate the side effects of spectrum sharing and interference caused by the SU, which for instance is equivalent to ∼8 dB (low signal‐to‐noise ratio (low‐SNR) regime) and to 15 dB (high‐SNR regime) SNR improvement.
Toward self‐financed distribution automation development: time allocation of automatic switches installation in electricity distribution systems
Authors: Fereidunian Alireza , Hosseini Mohammad Mahdi , Abbasi Talabari Mohammad
Published: May 2017

It has been decades since automation was introduced to electrical networks, yet it has not found its right place in the distribution level. One of the main obstacles in the path of automating electricity distribution system is the amount of investments needed for its implementation. This study presents a novel idea for distribution automation (DA) implementation planning, in which the sequence and timings of installing automatic switches are optimised, to exploit periodical savings and to minimise the total externally financed investment. The planning optimisation problem is formulated and solved in a mixed‐integer non‐linear form. The monetary value of periodical savings depends on several factors including network size, type of the distribution system operator, local regulations etc. To include all these factors, a scenario‐based method is developed to test the proposed method. Finally, the method proposed is tested on parts of the network covered by Tehran Vicinity Electricity Distribution Company as well as bus number four of Roy Billinton test system. The results show that a considerable part of investments needed for DA can be financed through exploiting periodical savings of DA, in a reasonable time, thus a partial self‐sufficiency can be reached for DA project financing.
Networked distributed automatic generation control of power system with dynamic participation of wind turbines through uncertain delayed communication network
Authors: Bijami Ehsan , Farsangi Malihe M.
Published: May 2017

This study proposes a new distributed networked control (DNC) scheme and its stability analysis framework for automatic generation control in networked interconnected power systems with participation of wind turbine. It is assumed that the remote control signals are measured at locations away from the control site and exchanged among a non‐ideal communication network with both time‐varying delays and random packet dropouts. First, a model is proposed for large‐scale DNC system consisting of subsystems, in which the states of each subsystem have their own time‐varying delay and there are also delay and packet dropouts in their interconnection links. Then, a linear matrix inequality (LMI)‐based method is proposed to design the distributed controller for better system performance. For this, a new Lyapunov–Krasovskii function is developed to conclude some LMI‐based delay‐independent theorem for designing control law. To evaluate the proposed method, a multi‐area power system with participation of wind turbine is considered. Simulation results show the capability of the proposed approach to enhance the performance of networked power system in the presence of load perturbation among a non‐ideal communication network with both time‐varying delays and random packet dropouts.
Intramedullary Teratoma in an Adolescent Patient
Authors: Kumar Sushil , Garg Amit , Sinha Rohan , Desai Ashish
Published: May 2017

Spinal teratomas are rare spinal tumors. Most patients present with myelopathy, myeloradiculopathy, or radiculopathy. The authors describe the rare presentation of spinal teratoma with acute onset of backache followed by sudden paraplegia.
Synthesis of 1-Alkyl-3-(2-oxo-2-aryl/alkyl-ethyl)indolin-2-ones through Gold/Brønsted Acid Relay Actions: Observation of Selective C=C Bond Cleavage of Enaminones
Authors: Li Yanzhong , Zhao Yulei , Yuan Yang , Kong Lingkai , Zhang Fangfang
Published: May 2017

A novel gold(I)/Brønsted acid sequential catalyzed/promoted procedure to synthesize 1-alkyl-3-(2-oxo-2-aryl/alkyl-ethyl)indolin-2-ones under mild reaction conditions is developed. This methodology is realized by relay actions of gold and a Brønsted acid in a one-pot multistep manner. The gold(I)-catalyzed chemoselective C(sp2)-H functionalization of enaminones and Brønsted acid promoted cleavage of the C=C bond are integrated effectively. Based on the results of control experiments and ESI-MS analysis, a possible reaction mechanism is proposed.
Know-how gezielt einkaufen
Authors: Freye Carolin
Published: May 2017

Drei von vier Krankenhäuser engagieren für die unterschiedlichsten Bereiche Unternehmensberatungen. Heutzutage kommt es v.a. darauf an, Mitarbeiter zu halten – dabei können Personalberatungen helfen. Welches sind die größten Sünden im Umgang mit Mitarbeitern? Welche Angebote, welche Unternehmensgepflogenheiten machen bei Fachkräften tatsächlich Eindruck? kma hörte sich bei Personalberatungen mit dem Schwerpunkt Krankenhäuser um und informiert z.B. über eine aktuelle Studie zur Wechselmotivation in der Pflege aus dem Hause Solute recruiting. Auch bezüglich des Klinikmanagements haben wir interessante Beiträge für Sie zusammengestellt: Jochen Baierlein und Thomas Rudolf von Oberender & Partner beleuchten das Thema Geschäftsbesorgungsmandate. Wann ist es sinnvoll, das Ruder langfristig aus der Hand zu geben und: Wie gehen Klinikbetreiber damit um? Zudem finden Sie in diesem Heft einen Leitfaden von Hans-Peter Schlaudt, Geschäftsführer von Jomec, zum richtigen Umgang mit Beleg- und Honorarärzten.

Viele gute Anregungen für Ihre Arbeit wünscht Ihnen Carolin Freye, Programmplanerin kma
Tipps vom Praktiker: 10 Knackpunkte für eine bessere Organisation
Authors: Herbold Rüdiger
Published: May 2017

Eine schlechte Organisation der Patientenversorgung, die täglichen Ärgernisse über Doppelarbeit, die mangelnde Informationsweitergabe, die häufige Revision von Entscheidungen und schlicht unnötige Arbeit – das sorgt für Frust bei Klinikmitarbeitern. Doch es gibt viele Möglichkeiten, wie man die Situation teils mit einfachen Maßnahmen verbessern kann.
Arbeitsrecht: Kliniken bangen um DRK-Schwestern
Authors: Doelfs Guntram
Published: May 2017

Nach einem aktuellen Urteil des Bundesarbeitsgerichtes (BAG) haben die 25.000 Rotkreuz-Schwestern in Deutschland ihren bisherigen arbeitsrechtlichen Sonderstatus verloren. Wenn sie von den 33 Schwesternschaften in Kliniken außerhalb des DRK eingesetzt werden, gelten sie seit dem 1. April laut Urteil als Leiharbeiterinnen. Das sorgt für Verunsicherung in vielen Kliniken.
Der Arzt als Mini-Jobber?
Authors: Weimer Tobias
Published: May 2017

Statt freiberuflicher Honorarärzte arbeiten in Kliniken immer öfter festangestellte Mediziner auf 450-Euro-Basis. Staatsanwälte sehen das kritisch.
Klinik Unternehmen: Auf-/Absteiger des Monats
Authors: Schmidt Hartmut
Published: May 2017

Börsenexperte Hartmut Schmidt analysiert für kma die Jahresabschlüsse* ausgewählter Kliniken
Selbstverwaltungsstärkungsgesetz: Mix aus Nickligkeiten und Selbstverständlichem
Authors: Paquet Robert
Published: May 2017

Das Selbstverwaltungsstärkungsgesetz greift tief in die Selbstverwaltung ein. Hintergrund sind Unregelmäßigkeiten bei der KBV. Die verschärften Regelungen gelten jedoch auch für die anderen Körperschaften, die der Aufsicht durch das Gesundheitsministerium unterstehen. Die deutsche Krankenhausgesellschaft ist fein raus: Sie hat keinen Köperschaftsstatus, sondern ist als eingetragener Verein organisiert.
Digitalisierung: „Der Rückstand des Gesundheitswesens wächst täglich“
Authors: Mau Jens
Published: May 2017

Als der Industrieverband bvitg vor zehn Jahren die conhIT einführte, war Jens Naumann der Verbandschef und Mitinitiator. Der Geschäftsführer des Praxissoftwareherstellers Medatixx blickt zurück und erklärt, welche Schritte aus seiner Sicht nötig sind, um die sektorenübergreifende Versorgung anzuschieben.
KIS-Markt: Die sieben großen Player
Authors: Mau Jens
Published: May 2017

Fulminante Übernahmen sind in den vergangenen zwei Jahren zwar ausgeblieben – der KIS-Markt ist dennoch kräftig in Bewegung. Hier stellt kma die sieben großen Anbieter von Krankenhausinformationssystemen (KIS) vor.
Künstliche Intelligenz im Krankenhaus: „Krankenhäuser werden dadurch schneller und besser“
Authors: Doelfs Guntram
Published: May 2017

Künstliche Intelligenz revolutioniert derzeit die Diagnostik bei vielen Krankenheiten. KI-Pionier Michael Forsting vom Uniklinikum Essen spricht über unbegründete Ängste mancher Kollegen, wie Patienten davon profitieren werden – und wie KI das Krankenhaus der Zukunft prägen und grundlegend verändern wird.
Branche in Zahlen
Authors: Mewis Dirk
Published: May 2017

Dieser Artikel ist nur als PDF-Dokument verfügbar.
Bildgebende Verfahren: „Deutliche Reduzierung der OP-Zeiten“
Authors: Mewis Dirk
Published: May 2017

Torsten Lutkat, Leiter Produktmanagement Starre Endoskopie bei Olympus Deutschland Medical Systems über intraoperative Bildgebung, Hybrideingriffe und das Gewebemanagementsystem Thunderbeat.
Neckar-Odenwald-Kliniken: Gnadenlose Transparenz: Der Weg aus der Krise
Authors: Pfeiffer Reinhard
Published: May 2017

Die Neckar-Odenwald-Kliniken (NOK) sind wieder auf Kurs. Nachdem die gemeinnützige Klinikgruppe 2013 wirtschaftlich in Schieflage geraten war, stellte der neu eingesetzte Geschäftsführer, Norbert Mischer, die Betriebskosten seiner Häuser auf den Prüfstand. Die Grundlage für das Sanierungskonzept bietet ein neues Benchmarking-Tool zur Wirtschaftlichkeitsanalyse des Klinikbetriebs: Es liefert innerhalb von wenigen Tagen direkt anwendbare Handlungsempfehlungen zur langfristigen Existenzsicherung von Krankenhäusern.
Hygienische Trinkwasserversorgung: Kein Bestandsschutz für marode Anlagen
Authors: Thalmayr Maria
Published: May 2017

„Vieles spricht dafür, die Anzahl der vertikalen Leitungsstränge zu erhöhen, um verschiedene Nutzungseinheiten auf einem Geschoß zu versorgen. Weil das Wasser dann nicht mehr durch ellenlange horizontale Rohre fließen muss, vermeidet man so das Risiko der Stagnation.“
Fachkräftemangel in der Krankenhaustechnik: Denn sie wissen nicht, was sie tun
Authors: Thalmayr Maria
Published: May 2017

Das Durchschnittsalter der FKT liegt derzeit bei 55 Jahren. Ein Großteil der Technikverantwortlichen im Krankenhaus steuert demnach auf den Ruhestand zu und wird in fünf bis zehn Jahren mit viel Erfahrung im Umzugskarton von der Bühne des Gesundheitswesens abtreten. Der eigentlich vorhersehbare Run auf geeignete Nachfolger könnte viele Krankenhäuser eiskalt erwischen.
Spiegelbild der digitalen Transformation: Der WGKT-Innovationspreis 2017
Authors: Hohenberg Gregor
Published: May 2017

Viele technische Innovationen stehen in einem direkten Zusammenhang mit der Weiterentwicklung der Krankenhaustechnik. Dies ist allerdings häufig nur auf den zweiten Blick erkennbar, was sich besonders gut bei digitalen Technologien beobachten lässt – die Auswirkungen sind aber umso weitreichender. Auch studentische Abschlussarbeiten spiegeln dies wider, wie der WGKT-Innovationspreis zeigt.
Michael Arattukulam: Jeder bekommt die medizinische Hilfe, die er braucht
Authors: Sickinger Nina
Published: May 2017

AUSLÄNDISCHE MITARBEITER BERICHTEN AUS DEUTSCHEN KLINIKEN Michael Arattukulam (41) wurde in Deutschland geboren und zog mit 8 Jahren mit seinen Eltern nach Indien. Zum Studieren kam er 1995 nach Deutschland zurück und arbeitet inzwischen als Oberarzt in der Pneumologie. Er schätzt das deutsche Gesundheitssystem – ganz im Gegensatz zur deutschen Bürokratie.
Epithelioid Hemangioendothelioma of Cavernous Sinus
Authors: Chandran Raj , Nair Jyotsna , Balachandran Krishna , Rajmohan Bhanu
Published: May 2017

Epithelioid hemangioendothelioma is an uncommon vascular neoplasm. It is rare in the intracranial location. Its occurrence in the region of cavernous sinus is reported only once. Here, we report a case of 49-year-old man who presented with a headache, pain in the right eye, diplopia, and ptosis due to third and sixth cranial nerve involvement. Imaging showed an enhancing lesion in the region of cavernous sinus on the right side. Pterional craniotomy, combined extradural and intradural approach, and subtotal excision of the tumor was done. Histopathology and immunohistochemistry were suggestive of epithelioid hemangioendothelioma which is a rare tumor in this location. We report this case because of its rarity and uncommon location.
Denied Suicide Attempt: Penetrating Cranial Cerebral Injury with a Nail Gun
Authors: Krauss Joachim , Lang Josef
Published: May 2017

Penetrating craniocerebral injuries with a nail gun are uncommon. In this article, we describe a highly unusual delayed presentation of a 49-year-old man after an initially unnoticed penetrating head injury with an air-powered nail gun. The nail was successfully surgically removed, and the postoperative course was uneventful. Further evaluation revealed that the penetrating craniocerebral nail gun injury was a suicide attempt and not an accident. Possible reasons for the initial unrecognition of the injury and denial of the suicide attempt were discussed.
Meningioma in Lateral Cerebellomedullary Cistern without Dural Attachment
Authors: Varghese Prithvi , Kandathil Julio , Govindan Jayasree , R. Rashmi , Jalal Muhammed
Published: May 2017

Intracranial meningiomas without dural attachment are rare and posterior cranial fossa meningiomas without dural attachment are rarer. Such meningiomas are thought to arise from arachnoid cap cells in pial membrane, tela choroidea, or choroid plexus. MRI is the best imaging modality for the diagnosis of meningiomas and typically shows an enhancing, dural based, extra-axial soft tissue mass with a characteristic dural tail. Meningioma without dural attachment should be suspected if the MRI shows a space-occupying lesion having features of a meningioma but without a dural base and dural tail. We report a case of meningioma in the lateral cerebellomedullary cistern without dural attachment.
Die Kosten von MRSA in der stationären geriatrischen Versorgung von Patienten am Lebensende (End-of-Life Care)
Authors: Adelhardt Thomas , Hessemer Stefanie , Docter Katrin , Sieber Cornel , Ostgathe Christoph , Schöffski Oliver
Published: May 2017

Ziel Die vorliegende Studie beschäftigt sich mit der Frage, welche finanziellen Auswirkungen das Auftreten von MRSA in einer geriatrischen Abteilung eines deutschen Krankenhauses bei Patienten am Ende des Lebens hat. Dabei sollen die Hauptkostentreiber identifiziert sowie die Kosten beziffert werden.

Methodik Eine retrospektive Analyse in einem Zeitraum von einem Jahr wurde für eine geriatrische Abteilung in einem Krankenhaus der Schwerpunktversorgung durchgeführt. Hierbei wurden neben der Verweildauer und den Gesamtkosten des Falls auch einzelne Kostenkategorien wie Personal- und Sachkosten erfasst. Um einen Kostenvergleich von MRSA-positiven und -negativen Patienten zu ermöglichen, wurde ein Matching-Verfahren durchgeführt.

Ergebnisse Insgesamt wurden 107 Fälle betrachtet, wovon bei 27 Fällen ein positiver MRSA-Befund vorlag. Bei Patienten mit positivem Befund konnte eine höhere durchschnittliche Verweildauer (16,93 vs. 15,05 Tage) und höhere durchschnittliche Gesamtkosten (6 601,32 vs. 5 984,78 €) des Falls beobachtet werden. Die beobachteten Unterschiede bei der Verweildauer zwischen Patienten mit positivem und negativem MRSA-Befund waren dabei jedoch nicht statistisch signifikant. Bei MRSA-Patienten konnten signifikant höhere Personalkosten des Pflegedienstes pro Tag in der Fallgruppe der Patienten mit unterdurchschnittlich hohen Gesamtkosten gezeigt werden. Diese lagen bei den MRSA-Patienten bei 97,18 € bzw. bei Nicht-MRSA-Patienten bei 80,44 €. Gegenläufige Tendenzen zeigten sich für die Personalkosten des ärztlichen Dienstes, des medizinisch-technischen Dienstes und den Sach- und Personalkosten der nichtmedizinischen Infrastruktur.

Schlussfolgerung Obwohl wir zeigen konnten, dass MRSA-Patienten auf der geriatrischen Station eine längere Verweildauer sowie höhere Gesamtkosten aufweisen, ergaben sich keine statistisch signifikanten Unterschiede zwischen MRSA-positiven und -negativen Patienten. Als ein Hauptkostentreiber in der Versorgung von Patienten mit MRSA konnten die Personalkosten des Pflegedienstes pro Tag identifiziert werden. Daher kann ein Ansatzpunkt zur effektiveren und effizienteren Versorgung in einer Analyse der Prozesse in Hinblick auf die Pflege von MRSA-positiven Patienten liegen. Die Versorgung von MRSA-Patienten war auf der betrachteten geriatrischen Station nicht in jeder betrachteten Kostenkategorie zwingend mit höheren Kosten im Vergleich zu Nicht-MRSA Patienten verbunden.
Morbus Castleman – eine harmlose Differenzialdiagnose einer Lymphadenitis colli? – Eine Fallserie
Authors: Riepl Ricarda , Hoffmann Thomas , Greve Jens
Published: May 2017

Der sehr seltene Morbus Castleman kann als potentiell schwerwiegende lymphoproliferative Erkrankung in Form einer zervikalen Lymphadenopathie manifest werden. Dem HNO-Arzt kommt dann eine entscheidende Rolle in der Diagnostik und Therapie zu. Ziel dieser Arbeit ist es, anhand einer Fallserie die Symptomatik, den Krankheitsverlauf bis zur Diagnosestellung und Nachsorge vor dem Hintergrund bestehender Evidenz zu beleuchten.

Eingeschlossen wurden Patienten, bei denen in den Jahren 2011–2015 die Erstdiagnose eines Morbus Castleman in der HNO-Klinik der Universität Ulm gestellt wurde. Evaluiert wurden u. a. die Dauer der bestehenden Symptome sowie die diagnostischen und therapeutischen Maßnahmen.

Gefunden wurden 5 Patienten (3 männlich, 2 weiblich) im Alter zwischen 15 und 43 Jahren. Die Dauer der wenig ausgeprägten Symptome war inkongruent und lag zwischen 14 Tagen und 14 Jahren. Bei allen Patienten konnte nach diagnostischer Exstirpation der Nachweis der hyalin-vaskulären Variante eines Morbus Castleman erbracht werden. In einem der 5 Fälle lag ein multizentrischer Typ mit zusätzlichem axillärem Befall vor, die anderen Fälle waren monozentrisch. Die diagnostische Exstirpation war in allen Fällen immer zugleich auch suffiziente Therapie ohne zusätzliche medikamentöse Adjuvanz. Zum Zeitpunkt der Veröffentlichung befinden sich alle Patienten in Remission (medianes Follow up=27 Monate).

Dem HNO-Arzt begegnet der Morbus Castleman zumeist als therapieresistente und längerfristig bestehende zervikale Lymphadenopathie mit wenig ausgeprägter Begleitsymptomatik und meist fehlenden laborchemischen Auffälligkeiten. Aufgrund der potentiell ungünstigen Verläufe ist eine zügige diagnostische Lymphknotenexstirpation in Vollnarkose indiziert, welche in den meisten Fällen gleichzeitig die suffiziente Therapie darstellt.
Effects of Synchronous Whole Body Vibration Training on a Soft, Unstable Surface in Athletes with Chronic Ankle Instability
Authors: Sierra-Guzmán Rafael , Jiménez Jose , Ramírez Carlos , Esteban Paula , Abián-Vicén Javier
Published: May 2017

The aim of this study was to evaluate the effects of a 6-week WBV training program, performed on a soft, unstable surface, on peak torque, reaction time and the electrical activity of ankle muscles in recreational athletes with chronic ankle instability (CAI). 50 recreational athletes with self-reported unilateral CAI were randomly assigned to a vibration group (VIB), non-vibration group (N-VIB) or control group. The VIB and N-VIB groups performed unilateral balance training on the unstable ankle on a BOSU® Balance Trainer 3 times weekly for 6 weeks. The VIB group trained on a vibration platform, and the N-VIB group trained on the floor. Muscle reaction times and electrical activity of the peroneus brevis (PB), peroneus longus (PL) and tibialis anterior (TA) muscles were assessed in response to sudden inversion, isokinetic peak torque and isokinetic strength ratios of the ankle evertor muscles. After 6 weeks of training, a significant improvement was shown in reaction times of the PB (Pre=60.99±9.17 ms, Post1=54.90±6.99 ms, p=0.003), PL (Pre=61.20±10.72 ms, Post1=55.21±9.04 ms, p=0.007) and TA (Pre=65.31±11.78 ms, Post1=59.07±9.99 ms, p=0.007) muscles in the VIB group, whereas no significant changes were found in the N-VIB group or the control group. There were no significant changes in electrical activity, peak torque and eccentric-concentric ratio for any of the groups after training. In conclusion, a 6-week WBV training program on a soft, unstable surface improves the reaction times of the PB, PL and TA muscles in recreational athletes with CAI.

Trial registration: ClinicalTrials.gov NCT02794194
Ein multimediales Programm zum Trainieren der Schilddrüsensonografie für Medizinstudenten
Authors: Ritter Julia , Wolfram Maximilian , Schuler Stefan , Guntinas-Lichius Orlando
Published: May 2017

Ärzte in Ausbildung haben häufig bei Berufseintritt aufgrund mangelnder Trainingsangebote im Rahmen ihres Medizinstudiums kaum Erfahrung in der Anwendung und Beurteilung der Sonografie. Daher sollte ein multimediales Programm für das schrittweise Erlernen und das Training der Schilddrüsensonografie entwickelt werden.

Es wurde eine Software zur Gestaltung eines multimedialen Lernprogrammes für ein tragbares Ultraschallsystem genutzt. Die Software erlaubt die Darstellung von Texten und Bildmaterial parallel zur Untersuchung, um eigene Befunde mit Beispielen aus einer Datenbank vergleichen zu können. Das fertiggestellte Tutorial wurde durch 8 Studierende evaluiert und mit einem Tutor-geführten Training verglichen.

Es wurde eine strukturierte, stufenweise Anleitung zur Schilddrüsensonografie mit einer Vielzahl von Beispiel-Sonografien in verschiedenen Schnittbildebenen gestaltet, die der Nutzer parallel am Probanden mit dem Ultraschallgerät nachstellt. Der Informationsgehalt des Tutorials und die Nachvollziehbarkeit der Untersuchungsschritte wurden positiv eingeschätzt. Die Übersichtlichkeit, die Eignung für Anwender mit fehlender Erfahrung und somit auch der Lernerfolg wurden hingegen unterschiedlich bewertet.

Das Tutorial zum Erlernen und zum Training der Schilddrüsensonografie ist ein Instrument zum Selbstlernen und zur Verbesserung der praktischen Ausbildung. In der nächsten Version wird die Untersuchungsanleitung noch detaillierter aufgebaut sein.
Effect of boron doping on first-order Raman scattering in superconducting boron doped diamond films
Authors: Kumar Dinesh , Chandran Maneesh , Ramachandra Rao M. S.
Published: May 2017

Aggregation of impurity levels into an impurity band in heavily boron doped diamond results in a background continuum and discrete zone centre phonon interference during the inelastic light scattering process. In order to understand the Raman scattering effect in granular BDD films, systematically heavily doped samples in the semiconducting and superconducting regimes have been studied using the excitation wavelengths in the UV and visible regions. A comprehensive analysis of the Fano resonance effect as a function of the impurity concentrations and the excitation frequencies is presented. Various Raman modes available in BDD including signals from the grain boundaries are discussed.
Freestanding nanostructures via reactive ion beam angled etching
Authors: Atikian Haig A. , Latawiec Pawel , Burek Michael J. , Sohn Young-Ik , Meesala Srujan , Gravel Normand , Kouki Ammar B. , Lončar Marko
Published: May 2017

Freestanding nanostructures play an important role in optical and mechanical devices for classical and quantum applications. Here, we use reactive ion beam angled etching to fabricate optical resonators in bulk polycrystalline and single crystal diamond. Reported quality factors are approximately 30 000 and 286 000, respectively. The devices show uniformity across 25 mm samples, a significant improvement over comparable techniques yielding freestanding nanostructures.