bluuebunny/crossref_metadata_2025 huggingface dataset:
The evolution of political power legitimacy conceptions
Authors: Ignatjeva Olga A.
Published: June 2024

The concept of the power legitimacy as one of the problems in the field of public administration was first mentioned by the German jurist G. Jellinek of the late 19th - early 20th century, then it was deeply developed in the theory of political domination by M. Weber. Realizing the importance of this issue, scientists from different countries one way or another turned to it and refined its various aspects. This article provides a critical analysis of the basic concepts of the legitimacy of power, based on the contribution to the development of this issue by M. Weber, D. Easton, I. Cerovac, J. Rawls, D. Estlund and J. Habermas. Since the problem of the legitimacy of power is directly related to the maintenance of a democratic regime, the declared concepts are considered in the context of the varieties of democracies for which they were created. The purpose of this study is not only to analyze successive concepts of the legitimacy of political power, but also to identify their relationship with the prevailing ideas about democracy in science and society at the time the concept appeared. The study was carried out within the framework of a systematic approach using general theoretical methods of analysis and synthesis, systematization and classification, as well as the case study method for country analysis.
Fostering family values and norms among students as a prerequisite for preventing an axiological crisis in society
Authors: Strelets Ilya E. , Mukhortov Denis S. , Markova Yulia S.
Published: June 2024

The article presents the results of a series of focus groups with Perm University students (n=36) on «Searching in optimal practices for promoting family values and norms among students». Analysis showed, inter alia, that 1) growing distrust of students towards the state, as well as schools and universities as conductors of state policy, weakens the disciplinary function of these institutions, yet 2) it is from schools and universities that students expect effective help in terms of sex education, and from the state they expect the suppression of «digital uncared-for-ness», which gives rise to sexual promiscuity and lack of cultural norms; 3) adults as agents of socialization are required to increasingly engage the students in socially significant activities and events, which would ultimately boost the level of his/her responsibility for his/her nears and dears, including future children; 4) it is essential to use game-like approaches to helping students solve their psychological issues by involving graduates of drama schools and/or psychology departments, 5) all activities at school, including academic disciplines of the arts and humanities cycle, should influence the teenager’s consciousness in terms of adopting models of successful interpersonal, and intergender, relationships; 6) it is advisable to fully support the projects of bloggers who are student opinion leaders and actively engage bloggers in the development of government initiatives. The article contributes to the plans by axiologists and the government to elaborate effective methods for regulating family relationships among students and maintaining traditional values in society.
Politicians’ Communicative Behavioural Patterns: A Study into British Parliamentary Discourses of 2010-2022
Authors: Mukhortov Denis S. , Zhovner Elisaveta A.
Published: June 2024

In recent years, linguopragmaticians have sought to make predictions as to why and how politicians resort to certain communicative behaviours, hence the focus of linguistic research. Drawing upon parliamentary discourses of Conservative Prime Ministers David Cameron, Theresa May, Boris Johnson and Labor Party leaders Jeremy Corbyn and Keir Starmer, this article aims to develop a new approach to naming communicative behavioral patterns of modern British politicians. The commonality of domestic political tasks faced by the politicians, namely the UK’s exit from the European Union, environmental agenda, migration reform, healthcare system troubles, have predetermined the choice of certain types of ‘communicative personality’ and, consequently, a selection of lexical means used by the politicians during parliamentary debates. The algorithm for typologizing the communicative behavior of politicians includes creating a corpus of utterances and analyzing it through the content analysis program Sketch Engine. A comparison of the most frequent lexical units used by a politician in given communicative situations have made it possible to identify prevailing types of ‘communicative personality’ and key intentions realized in the course of political communication.
Archaization in "Child Christopher and Goldilind the Fair" by William Morris
Authors: Koltysheva Elena Y. , Shibaeva Anastasia A.
Published: June 2024

В статье исследуются средства архаизации художественного текста на фонетическом, морфологическом, лексическом и грамматическом (синтаксическом) уровнях языка. Архаизация, или историческая стилизация, как комплексное преобразование языка, не ограничивается уровнем лексики - архаизмами. В качестве материала исследования выбран фэнтези-роман Уильяма Морриса «Child Christopher and Goldilind the Fair» как пример кропотливой архаизации художественного текста. Авторы статьи приходят к выводу о том, что в романе У. Морриса язык - это, скорее, самоценный объект творчества, нежели средство создания сеттинга. Архаизация в «Child Christopher and Goldilind the Fair» весьма условна, поскольку роман в жанре фэнтези не имеет цели воссоздать какой-либо исторический период, а архаизация несет главным образом эстетическую функцию и переносит действие романа в «прекрасное абстрактное прошлое». В результате исследования выделены разнообразные средства архаизации художественного текста на английском языке. Фонетические особенности передаются с помощью архаичной орфографии; на морфологическом уровне применяются устаревшие принципы словообразования; архаизация на лексическом уровне представлена архаизмами (в том числе семантическими) и историзмами; на уровне грамматики это устаревшая глагольная парадигма, архаичные грамматические конструкции и особый синтаксис.
Competências Docentes para o Trabalho Híbrido e para a Educação a Distância em Tempos de Pandemia
Authors: Brant Rogério Santos , Costa Danilo , Medeiros Leonardo Guimarães
Published: July 2024

É notório o impacto da pandemia de COVID-19 na educação superior, com destaque para a transição para o ensino remoto e híbrido. A adoção de novas tecnologias educacionais e modelos de ensino e aprendizagem trouxe à tona a importância da flexibilidade e da tecnologia no ensino superior, assim como a necessidade de desenvolvimento de novas competências para professores que atuam na modalidade de Educação a Distância (EaD). Este estudo tem como objetivo analisar as competências essenciais dos professores na modalidade EaD, necessárias para atuação no curso de Administração, advindas do contexto do ensino remoto durante a pandemia. Possuindo uma abordagem qualitativa e descritiva, esta pesquisa se utilizou de pesquisa documental e aplicação de entrevistas semiestruturadas à professores de uma Instituição de Ensino Superior no norte do estado de Minas Gerais. Os resultados apontam, que as competências funcionais e comportamentais possuem os maiores destaques. Após o isolamento social, ficou ainda mais claro a percepção da competência comportamental. Transparece-se a necessidade constante do aprimoramento das competências dos professores para atuação na Educação à Distância.
TALES IN TECH
Authors: Tan Kim Hua , Ngoi Shirley , Yunos Nasruddin , Alias Jamsari , Mat Norazila
Published: July 2024

Integration of digital storytelling in education has transformed traditional teaching methods to foster active student participation in classroom settings. With the increasing use of digital storytelling, there is a necessity to delve deeper into its effective implementation, effects, and the changing learning environment. The lack of a comprehensive understanding has emphasized the need to fully leverage digital storytelling to enrich students’ learning experiences. Therefore, this scoping review aims to investigate the effectiveness of digital storytelling in different educational settings and explore the challenges related to digital literacy skills met by teachers and students, impacting the efficient implementation of digital storytelling. Using the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA), a total of 51 articles from 2019 to 2023 were selected from Scopus in order to illustrate the current state. The articles were analyzed based on their similarities, and the results were tabulated in the following tables. The findings concluded that digital storytelling is an excellent method for improving literacy abilities, enhancing computational thinking and developing digital knowledge and intelligence among students. The findings also implied that longitudinal studies should be conducted more in the future to figure out how digital storytelling affects students' academic and career growth over time.
Kitābu’t-Taḥrīş ve Kitābu’r-Rudūd: Kim Kimi Etkiledi?
Authors: Kır Bilal
Published: June 2024

Ḍırār b. ʿAmr ve ʿAbdullāh b. Yezīd el-Fezārī, dönemlerinin önde gelen kelâmcıları arası yer almışlardır. Onlara dair bilgilerimiz çok uzun bir süre sadece makâlât ve tarih kitaplarındaki anlatımlara dayanıyordu. Yakın tarihimizde bu eksikliği gideren gelişmeler oldu. Ḍırār’ın günümüze intikal eden ilk ve tek eseri olan Kitābu’t-Taḥrīş, 2014 yılında neşredildi. Bu eser, doğrudan kelâm alanıyla ilgili olmasa da mezheplerin dağılımı ve fikirleri hakkında bilgiler ihtiva eden en eski Muʿtezilî kaynaklar arasında yer almaktadır. Ḍırār bu kitabında farklı dinî grupların rivâyetleri birbirlerine karşı nasıl kullanıp suistimal ettiklerini konu edinmiştir. Eserin özelliği sadece ihtiva ettiği rivâyetlerde değil, meseleyi ele alış ve anlatım tarzında da bulunuyor. Ḍırār bu çalışmasıyla sonraki nesilleri birçok yönden etkilemiştir. ʿAbdullāh b. Yezīd el-Fezārī, eserlerinin günümüze ulaşması bakımından daha şanslıdır. Bir proje kapsamında 2014 yılından itibaren onun tam on bir eseri yayımlanmıştır. Bunlar arasında kelâm ilmine hasredilmiş birçok neşir yer almaktadır. Böylece çağdaş İslâm araştırmacıları ʿAbdullāh’ın fikirlerini az sayıdaki makâlât referanslarından bağımsız olarak doğrudan kendi kaleminden öğrenme imkanı elde etmiş oldular. Bunun ötesinde bu çalışmalar erken dönem kelâm ilminin en eski kaynakları arasına girmiştir. Bu yayımlar arasında özellikle Kitābu’r-Rudūd dikkat çekmektedir. Sebebi ise Kitābu’t-Taḥrīş ile olan benzerliğinden dolayıdır. Neredeyse her iki kitabın tamamı birbirinin aynısıdır ve karşılıklı atıflar içermemektedirler. Bu tür bir yazım faaliyeti günümüzde tereddütsüz intihal olarak adlandırılırdı. İki mütekellim arasında kronolojik farklar olmadığından kimin kimden etkilendiğini söylemek ilk aşamada zordur. Ḍırār ve ʿAbdullāh’ın birbirlerinden haberdar oldukları anlaşılıyor: İkisi de Kûfe’de yaşamış, Abbâsî halifesi Hārūn er-Reşīd döneminde (786-809) Bağdat’a geçmişler ve orada Hişām b. el-Ḥakem’le (ö. 179/795) imâmete dair Yaḥyā b. Ḫālid el-Bermekī’nin (ö. 190/805) rehberlik ettiği aynı münazara ortamında bulunmuşlardır. Eserlerin özgünlüğü ve etkisi hasebiyle bu çağdaş hemşehrilerden kimin kime kaynaklık etmiş olabileceği sorusu merak uyandırıyor. İkisinin de hem rivâyetleri merkeze alan bir eser vermek için hem bu tür bir telifin fikir babası olmasına delalet eden gerekçeleri var. Bu makalede, öncelikle ikisinin biyografik benzerlikleri takdim edilmiş, akabinde iki eser arasında mukayeselere yer verilmiştir. Kıyaslama, eserlerin hayat öyküleriyle uyumlulukları ve eserlerin tertip ve düzeni üzerinden yapılmıştır. Yöntem olarak aralarındaki paralelliklerden çok farklılıklara odaklanılmıştır. Son olarak ikisinin dayandığı ortak bir kaynağın varlığı sorgulanmıştır. Bu emârelerden hareketle kimin kime öncülük etmiş olabileceğine açıklık getirilmek amaçlanmıştır.
Hayâlî’nin Düşüncesinde Değerin Kaynağı ve Fiillerin Değeri
Authors: Aydın Mehmet
Published: June 2024

Makalede, Osmanlı bilgini Şemseddin Ahmed b. Musâ el-Ḫayâlî’nin düşüncesi bağlamında değerin imkânı ve fiillere değer yüklemenin kaynağı sorununun incelenmesi amaçlanmıştır. Mu‘tezile ve Eş‘arîler karşısında Hanefî-Mâtürîdî gelenekte değer konusuna yaklaşımın ne olduğu sorusu Hayâlî’nin görüşlerine referansla ele alınmıştır. Hayâlî, kendi düşüncesini, hocası Hızır Bey’in el-Ḳaṣîdetü’n-nûniyye adlı kasidesine yazdığı şerhte ortaya koymuştur. Özellikle bu kasidenin “iyilik ve kötülük şer‘îdir ama/ biz bunların akılla bilinebileceğini söylüyoruz” dizelerinin yorumunda hüsun ve kubuh meselesini incelemiştir. Onun düşüncelerinin analiz edilmesi ve yorumlanmasında Muhammed Ömer b. eş-Şeyh Abdi’l-Celîl b. eş-Şeyh Abdi’l-Cemîl el-Bağdâdî el-Hanefî’nin Ḥavâşî’l-Futûḥiyye li-Şerḥi’n-Nûniyye ve Mehmet Emin Üsküdârî’nin Ḥâşiye ʿalâ Şerḥi Hayâlî ‘ale’l-Ḳaṣîdeti’n-nûniyye adlı eserinden yararlanılmıştır. Eş‘arîler, insan için değer bilgisinin mümkün olmadığını iddia ederek, iyi ve kötü hakkındaki bilgimizin kaynağının din olduğunu kabul etmişlerdir. Mu‘tezilî düşünürler ise iyi ve kötüyü fiillerin zatına ya da fiillerin zatında bulunan sıfatlarla ilişkilendirmişlerdir. Cübbâîler gibi bazı Mu‘tezilî düşünürler, fiillerin yapıldığı bağlamın ve şartların da değer atfetmede önemli olduğunu ifade etmişlerdir. Değer konusunda, Buharalı Hanefî âlimler Eş‘arî değer anlayışına yakın dururken, Mâtürîdîler Mu‘tezilî fikirlere yakın durmuşlardır. Mâtürîdîler, dinin iyi ve kötü hakkında bilgi verdiğini kabul etmekle birlikte bazı şeylerin değerinin akılla bilinebileceğini iddia etmişlerdir. Çalışmamızda, Hayâlî’nin temel yaklaşımının Mâtürîdîlerin değer anlayışından yana olduğu gösterilmiştir. Fiillere yüklenen iyi ve kötünün anlamları konusunda Mu‘tezile ve Mâtürîdîler arasındaki benzerliklere dikkat çekilmiştir. İyi ve kötünün üç anlamının olduğu açıklanmıştır. İlk olarak iyilik, bir insanın fiilinin bu dünyada övülmesi ve ahirette ödüllendirilmesi anlamına gelir. Kötülük, bu dünyada yerilmeyi ve ahirette cezalandırılmayı ifade eder. İkinci olarak, iyi, amaca uygun olandır ve kötü ise amaca uygun olmayandır. Bu, aynı zamanda, iyinin yararlı olan ve kötünün de zararlı olan olduğu anlamına gelmektedir. Üçüncü olarak iyi, bir yetkinlik sıfatıdır ve kötü de bir eksiklik sıfatıdır. Örneğin bilgi, insanı yetkinleştirdiği için iyidir. Bilgisizlik, insanı eksik ve düşük bir durumda bıraktığı için kötüdür. Mu‘tezile’ye göre her şeyin iyilik ve kötülüğü akılla bilinirken, Mâtürîdîlere göre bazı şeylerin iyilik ve kötülüğü akılla idrak edilebilir. Bu bağlamda Mu‘tezilî ve Mâtürîdî düşünürler, sorumluluğu gerektiren değer bilgisinin kaynağının din olduğunu kabul eden Eş‘arîlerin argümanlarını eleştirmişlerdir. Makalede, ayrıca, tek bir cümlede doğruluk ve yanlışlığın birleşmesiyle ortaya çıkan yalancı paradoksu ile değerin kaynağı arasında kurulan ilişki ele alınmıştır. Yalancı paradoksunun bir çözümünün olduğuna inanan Hayâlî, bu çözüm üzerinden, Mâtürîdî değer anlayışının haklı gösterilebileceğini ifade etmiştir.
Fahreddin Râzî ve Sirâceddin Urmevî’nin Varlık Eksenli Rü’yetullah Tartışmaları
Authors: Turgut Hüsnü
Published: June 2024

Allah'ın görülebilirliğini ifade eden rü'yetullah kavramı, tarih boyunca farklı kelâm disiplinleri tarafından derinlemesine incelenmiş önemli bir konudur. Kelâm tarihinde, rü’yetullah’ı kabul edenler ve reddedenler olmak üzere bu konuda ana hatlarıyla iki temel bakış açısı bulunmaktadır. Ehl-i Sünnet, rü’yetullahı benimseyen grupların başında gelirken; Muʻtezile mezhebi ise rü’yetin cisimliği içermesi veya onunla ilişkili bazı konuları gerektirmesi nedeniyle onun ulûhiyet makamıyla uyumsuz olduğunu düşünerek kesin bir dille reddetmiştir. Rü’yeti kabul edenler aklî ve naklî birtakım temellendirmelere başvurmuşlardır. Ehl-i sünnet perspektifinden bakıldığında, erken dönemde rü’yetullahın “zâtıyla kıyâm” esasına dayalı olarak temellendirilirken; bilahare “varlık” esaslı temellendirildiği görülmektedir. Bu çalışmada Eşʻarî mezhebine mensup iki düşünür olan Fahreddin er-Râzî (ö. 606/1210) ve onun yakın takipçisi Sirâceddin el-Urmevî’nin (ö. 682/1283), varlık eksenli rü’yetullah konusundaki yaklaşımları ele alınacaktır. Râzî, birçok konuda birbirinden farklı görüş serdeden muhakkik bir âlimdir. Birden fazla görüş beyan ettiği mevzulardan biri, varlık merkezli rü’yetullahın temellendirilip temellendirilemeyeceğidir. O, varlık merkezli rü’yetullahın temellendirilmesi yöntemine dair kabul, ret ve tevakkuf olmak üzere üç farklı yaklaşım sergilemektedir. Onun başta rü’yetullah olmak üzere birçok metafizik ve teolojik konuda fikirlerini değiştirmesini, benimsediği yaklaşımları farklı açılardan temellendirmesi, bir taraftan onun felsefî ve kelâmî derinliğini ortaya koyarken, diğer taraftan ise onun tahkik yöntemiyle doğrudan ilişkilidir. Bu yüzden Şihâbüddîn el-Karâfî (ö. 684/1285) gibi düşünür şarihler, Râzî’nin düşüncesindeki bu değişimi, onun bilgisinin olgunluğuna, aklî yeteneklerinin üstünlüğüne ve dinî kavrayışının derinliğine bağlamışlardır. Nitekim bu değişim, Râzî'nin her daim hakikat arayışında olduğunu ve fikirlerini sürekli sorguladığını göstermektedir. Birçok eserinde “varlık” odaklı rü’yetullaha dair çeşitli eleştiriler yapan Râzî, Erʻbaîn adlı eserinde bu konuyu daha düzenli bir sistem içinde ve maddeler halinde açıklamaya gayret etmektedir. Mezkûr eserinde Râzî, varlık merkezli rü’yetin temellendirilemeyeceğine dair “ʻâdemin malûliyeti”, “her hükmün bir illete dayanmasının zorunlu olup olmadığı” ve “cevher ve arazların farklı illetlerle muallel olup olamayacağı” gibi birtakım felsefî ve kelâmî delilleri merkeze koyarak eleştirisini temellendirmeye çalışmaktadır. Râzî'nin bu eserini özetleyen ve eleştiren Urmevî, Lübâb’da, Râzî’nin tespitlerine itiraz edip sunduğu argümanlara karşı çıkarak, varlık merkezli rü’yetullahın temellendirilebileceği düşünmektedir. Her iki düşünürün rü’yet merkezli ortaya koydukları argümanlar, bir taraftan Tanrı tasavvurlarını ortaya koyarken; diğer taraftan ise felsefî ve teolojik duruşlarına da ışık tutmaktadır.
Instrumental support for constructing and using system-object three-dimensional classification
Authors: Gul Svetlana Vladimirovna ,   Belgorod State National Research University, Fedorenko Alexey Vitalevich , Matorin Sergey Igorevich ,   Belgorod State National Research University,   Belgorod State National Research University
Published: July 2024

The article discusses the problem of instrumental support for construction and use procedures using the system-object approach of three-dimensional classification (SO3K). The possibilities of forecasting and management support using CO3K are shown using specific examples. The results of a study of the existing tools for conceptual classification modeling (ontological engineering) are presented, showing that with its help it is impossible to ensure the construction and use of CO3K. In order to create instrumental software that supports the construction and use of CO3K, a set of functional requirements for it has been developed in the form of a UML diagram of use cases (precedents) and activity diagrams as event flows for them.
Development of a transcutaneous form of desloratadine
Authors: Ageev Valentin P. , Zaborovskiy Andrey V. , Yunina Dina V. , Tararina Larisa A. , Devkota Mikhail K. , Andreev Dmitry N. , Pyanzina Aleksandra E. , Shlyapkina Vasilisa I. , Buldygina Yulia A. , Kulikov Oleg A. , Pyataev Nikolay A.
Published: June 2024

Introduction: For people with allergies, it is not always possible to prevent allergens admission to the body. For this reason, it is essential to create a long-acting drug that can prevent an allergic reaction. The very promising option is a transdermal therapeutic system (TTS), with H1 blockers. The aim of the study: To create a technology for the production of desloratadine-based TTS, suitable for routine use with prolonged drug releasing.
Materials and Methods: Polyvinylpyrrolidone K30 (PVP) was used as the main matrix polymer for TTS, and the Kruofilm polymer membrane was used as the adhesive layer. The formation of the polymer membrane was carried out by drying a water-alcohol solution of the components at a temperature of 60ºC. Characterization of the obtained dosage forms was made by spectrophotometry. The resulting micelles size was measured by dynamic light scattering.
Results and Discussion: Round shaped TTS (patches) with water-dissolved DL and its micellar form were obtained. The size of micelles with DL was 22.8±5.2 nm. The spectrophotometric method for determining DL has been developed. The containing of DL in the patches ranged from 5 to 25 mg per patch, depending on the manufacturing technology.
Conclusion: We have developed TTSs containing DL by a solution and a micellar form. A top adhesive layer has been selected that has moisture resistance, strength and reliable fixation of the matrix with the active substance on the skin. A method for the spectrophotometric determination of DL in solutions and patches was developed and validated.
Global survival of pediatric patients with acute lymphoblastic leukemia from a Latin American Hospital
Authors: Altamirano-Molina Milagros , Seminario-Azula Esthefany , Díaz-Bardales Carol , Pacheco-Modesto Iván , Amado-Tineo José
Published: June 2024

Background: Acute lymphoblastic leukemia (ALL) is the most common neoplasm in pediatric and adolescent populations. Overall survival has improved in recent decades. This study aimed to assess the overall survival of patients with pediatric ALL in a Latin American hospital.
Materials and Methods: A longitudinal and retrospective analytical study was conducted on 31 patients less than 16 years of age diagnosed with ALL at the hematology department of a Peruvian hospital during the period 2015-2016. Overall survival at 5 years was determined using the Kaplan-Meier curve with parametric log-rank tests, and the Cox regression model was employed to ascertain the hazard ratios of significant variables.
Results: The average age was 6 years, and 21 (67.7%) were female. The 5-year overall survival rate was 35%, with a median survival of 33 months (95% CI = 34.078-66.861). Being 10 years or older was associated with lower survival (p = 0.002). No significant association with B-cell acute lymphoblastic leukemia was found (p = 0.057).
Conclusion: The overall survival rate obtained was similar to that reported in other local studies; however, several international studies have reported better survival rates compared to our findings. Age was identified as a significant factor affecting survival.
Evaluating the expression of LKB1, SHMT1, and GLDC genes in Acute Lymphoblastic Leukemia patients
Authors: Farajzadeh Pegah , Postdoc Flora Forouzesh , Nabigol Maryam , Farsani Mehdi Allahbakhshian
Published: June 2024

Background: Epigenetic changes in cancer cells have an immense effect on tumorigenesis. As a tumor suppressor and an epigenetic regulator, liver kinase B1 (LKB1) reduces gene methylation by downregulating metabolic pathways such as the serine-glycine pathway. This study seeks to examine the gene expression levels of serine hydroxymethyltransferase 1 (SHMT1) and glycine decarboxylase (GLDC), as two serine-glycine pathway regulatory genes, along with LKB1 in acute lymphoblastic leukemia (ALL) patients.
Materials and Methods: In this analytical study, qRT-PCR was used to evaluate the gene expression levels of LKB1, SHMT1, and GLDC in 50 ALL patients with an average age of 11.64 ± 10.6 years. The patients were compared to 10 healthy controls. Subsequently, the correlation between the gene expression levels and the patients’ demographic data was investigated.
Results: No significant difference was found between the ALL patients and the control individuals in terms of LKB1 and GLDC gene expressions, but SHMT1 was significantly overexpressed in the ALL patients (p = 0.003). Moreover, there was a significant association between GLDC and the other SHMT1 (p = 0.020) and LKB1 (p = 0.047). No significant connection was also found between the age (pL = 0.304, pS = 0.305, pG = 0.899), gender (pL = 0.475, pS = 0.299, pG = 0.388), and blast percentage (pL = 0.335, pS = 0.148, pG = 0.459) of the patients and the genes.
Conclusion: The increased expression of SHMT1 suggests the oncogenic role of this gene. Thus, the present study offers a novel diagnostic marker in ALL patients.
Pediatric Myelofibrosis: A Rare Entity Posing a Diagnostic Challenge
Authors: Puri Vandana , Sharma Kusha , Sharma Sunita , Shukla Shailaja , Parakh Nupur
Published: June 2024

Myeloproliferative neoplasms are clonal hematopoietic stem cell disorders showing proliferation of one or more myeloid lineages. These disorders are characterized by Janus Kinase 2 (JAK2 V617F), Myeloproliferative leukemia (MPL), and Calreticulin (CALR) gene mutations and are seen more commonly in the elderly. These pathognomonic mutations are often absent in children and hence pose a diagnostic challenge. The entire onus of correct diagnosis relies heavily on detailed clinical and laboratory investigations. In the present work, we discuss 4 cases of pediatric myelofibrosis, three of which were secondary to hematolymphoid malignancies, while the remaining one had primary myelofibrosis. Pediatric primary myelofibrosis is a rare entity in children and quite different from adult primary myelofibrosis. The cases in our study show transformation into acute myeloid leukemia, which is associated with an adverse prognosis. Given the rarity of myelofibrosis in children, early and correct diagnosis helps in timely initiation of treatment, which may favorably alter the prognosis.
Confirmation of the Spiritual Nature of Individual and Society in Yevhen Spektorskyi’s Works of the Emigrant Period
Authors: Krupyna Oksana
Published: July 2024

The article presents the main issues of the works by the famous philosopher, jurist and educator Yevhen Vasyliovych Spektorskyi (1875‒1951) written during the period of forced emigration (1920‒1951) and professional activity at the universities of Belgrade, Prague, Ljubljana and the St. Volodymyr Orthodox Theological Seminary in New-York. In the intellectual biography of the thinker, these prolific years are marked by the development of issues in social science, philosophy, moral theology, and Christian ethics. In numerous works in various foreign languages, some of which have been analyzed in this article for the first time, Spektorskyi substantiated the importance of moral — as opposed to physical and mental — dimension of the existence of both individuals and society, for which he regarded the Christian religion to be a reference point. The latter, in his opinion, can truly explore the essence of the individual and social with the help of Christian sociology. The history of social philosophy is essential for social science as well as philosophy itself. Positioned between science and religion, philosophy has the capacity for free thinking, which is crucial for achieving a genuine understanding of society. As it is revealed in the article, the philosopher developed ethical guidelines within the framework of moral theology, criticizing naturalistic and mechanistic approaches to understanding society and the individual. Spektorskyi regarded freedom, dignity, and a righteous life according to the Christian ideal, as well as cultural activity, as fundamental values. The author argues that Spektorskyi’s affirmation of absolute values and the study of the relationship between the individual and society on the basis of the Christian religion provide grounds for evaluating Spektorskyi as an exceptionally religious philosopher.
The Effect of Hypertension on the Risk of Premature Birth: Meta Analysis with Binary Data
Authors: Nur'aini Rizky , Ratnasari Andika Putri
Published: June 2024

Hypertension in pregnancy is a condition where systolic blood pressure increases to more than 140 mmHg and diastolic more than 90 mmHg. Apart from endangering the mother, hypertension is also dangerous for the fetus. We conducted a meta-analysis of articles on the risk of premature birth in pregnant women with hypertension. The research method was carried out by searching for scientific articles in the PubMed and ScienceDirect databases to see if they contained control cases/cohorts of the influence of hypertension on premature birth with N>200. From the search results, 8 eligible journals were selected, namely those containing the relevant independent variable hypertension. The results show that the risk of premature birth is influenced by pregnant women who experience hypertension = 3.971 (95% CI, 2.567; 6.144) with a random effect model because high heterogeneity was detected (I2 = 98.992%). This shows that hypertension experienced by pregnant women can increase the risk of premature birth by 4 times. Hopefully, these results can improve health policies that enable more appropriate treatment, and for pregnant women to carry out routine early examinations and maintain nutritional intake and a healthy lifestyle.
Digitalisation and income inequality in Central and Eastern European countries
Authors: Kuźmar Sławomir , Piątek Dawid
Published: June 2024

The COVID-19 pandemic has highlighted the importance of digital technologies in business and daily life. The paper aims to explore the theoretical and empirical aspects of the relation between digitalisation and income inequality in Central and Eastern European (CEE) countries between the years 2000-2020. It contributes to existing research on determinants of income inequality, focussing on the potential negative role of digitalisation as an unnoticeable driver of income inequality in CEE countries. To investigate the potential impact of digitalisation on income inequality, empirical analysis was performed for the sample of 10 CEE countries, namely Bulgaria, the Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Romania, the Slovak Republic and Slovenia. The results of canonical correlation analysis indicated that the sets of variables related to digitalisation and inequality as a group are significantly related to each other and a strong correlation exists between them. The relative contribution of each indicator to each standardised function showed that the highest values of significant standardised coefficients were observed for income inequality indicators such as the top 10% share, the Gini coefficient, and the top 1% share, while in digitalisation measures, the highest value was observed for Internet users and fixed and mobile broadband subscriptions.
NA Barcoding as a Method of Genetic Identifi cation of an Individual: Problems and Prospects
Authors: Belov Oleg A. ,   Associate Professor of the Department of Criminalistics of the Kutafi n Moscow State Law University (MSAL), PhD (Law), Associate Professor
Published: July 2024

The article analyzes opportunities of using the method of DNA identifi cation of an individual with the help of genetic barcoding within corruption combating activities. The author describes principles of digitizing genetic information to create a genetic barcode for further registration in the database. The paper also reviews problems of the development of a federal genome information database based on SNP analysis.
Visual Learning Analytics for Educational Interventions in Primary and Secondary Schools
Authors: Mohseni Zeynab , Masiello Italo , Martins Rafael M. , Nordmark Susanna
Published: June 2024

Visual Learning Analytics (VLA) uses analytics to monitor and assess educational data by combining visual and automated analysis to provide educational explanations. Such tools could aid teachers in primary and secondary schools in making pedagogical decisions, however, the evidence of their effectiveness and benefits is still limited. With this scoping review, we provide a comprehensive overview of related research on proposed VLA methods, as well as identifying any gaps in the literature that could assist in describing new and helpful directions to the field. This review searched all relevant articles in five accessible databases — Scopus, Web of Science, ERIC, ACM, and IEEE Xplore — using 40 keywords. These studies were mapped, categorized, and summarized based on their objectives, the collected data, the intervention approaches employed, and the results obtained. The results determined what affordances the VLA tools allowed, what kind of visualizations were used to inform teachers and students, and, more importantly, positive evidence of educational interventions. We conclude that there are moderate-to-clear learning improvements within the limit of the studies’ interventions to support the use of VLA tools. More systematic research is needed to determine whether any learning gains are translated into long-term improvements.
The Influence of Changes in Cosmetic Consumers’ Purchase Behavior on Cosmetic Sales Workers’ Organizational Commitment in Department Stores in the Post-Pandemic Era: Focusing on the Mediating Effects of Cognitive Flexibility
Authors: Park Su Mi , Jeong Jae-Hyung ,   The Korean Society of Beauty and Art
Published: July 2024

Since the onset of the pandemic, there have been noticeable shifts in consumers’ purchase behaviors. These changes have had a significant impact on sales workers, especially in the department store cosmetics sector. Amidst these circumstances, cosmetic sales workers have been encountering challenges stemming from the shifts in consumers' purchasing behaviors. In this context, this study aimed to investigate the impact of sales workers' perceptions of these changes in consumers' purchasing behaviors after the pandemic on organizational commitment among department store cosmetics sales workers. Additionally, it sought to uncover the relationships that could influence these effects through the mediating role of cognitive flexibility. To accomplish this, a questionnaire survey was administered to 555 department store cosmetics sales workers between June 20 and July 20, 2023. To ensure the validity of the study, a research model was tested, using SPSS WIN 25.0. This study investigated whether changes in consumers' buying behavior (independent variable) affected department store cosmetics sales workers' organizational commitment (dependent variable), and whether cognitive flexibility played a mediating role in this relationship.
The study found that shifts in consumers' purchase behavior had a statistically significant negative impact on organizational commitment. However, cognitive flexibility was identified as a mediator in the relationship between changes in consumers' purchase behavior and sales workers' organizational commitment. In other words, as sales workers become less aware of changes in consumers' purchase patterns and enhance their cognitive flexibility, their organizational commitment increases. These findings are expected to assist cosmetics businesses in swiftly adapting to new environments, while also enabling sales workers to enhance their organizational commitment by developing cognitive flexibility. Additionally, in the post-pandemic era, it is anticipated that cosmetics businesses will remain competitive and continue to grow by implementing customized strategies and leveraging the competence of their sales workers in response to rapidly changing business environments.
Prospective comparative analysis of the ambulatory blood pressure monitoring changes in patients with hypertension after COVID‑19 in the conditions of the Arctic watch
Authors: Vetoshkin A. S. , Shurkevich N. P. , Gapon L. I. , Kareva M. A.
Published: July 2024

Objective. To conduct a prospective (2-year) comparative analysis of the dynamics of 24-hour ambulatory blood pressure monitoring (ABPM) in patients with arterial hypertension (HTN) and previous COVID-19 infection working in the conditions of the Arctic watch.

Design and methods. In the Medical Unit of Gazprom Dobycha Yamburg LLC (GDY) in the polar shift settlement of Yamburg, 347 patients were examined: 222 men (M) and 125 women (W). All of them underwent ABPM according to the standard protocol in 2019 and 2022. Among them, 261 patients had confirmed COVID-19 between 2020 and 2021 and were treated in the Medical Unit of GDY. Among the examined M and W, according to medical history in 2019, 80 % of M (178 from 222 people) and 66 % of W (82 from 125 people) had elevated blood pressure (BP), p = 0,003. Among patients with HTN, 109 M (61,2 %) and 42 W (51,2 %) survived after COVID-19, p = 0,129. They formed observation group (n = 151). Comparison group included HTN patients without COVID-19 (n = 109).

Results. In patients with HTN who had COVID-19, ABPM showed an increase in average daily systolic BP (SBP) values after 2 years: from 134,5 (12,3) to 140,5 (11,8) mmHg (p < 0,0001) and diastolic BP (DBP): from 96,6 (14,0) to 105,1 (13,4) mmHg (p < 0,0001), hypertensive load time indices (TI): TI SBP24 (from 49,5 (29,3) to 61,6 (28,1) mmHg (p < 0,0001) and TI DBP24 from 69,3 (30,5) to 83,4 (21,9) mmHg (p < 0,0001), increase in daytime SBP variability (p = 0,048), decrease in daily SBP indices by 1,2 %: from 7,9 (4,6) to 6,7 (4,3) (p = 0,038) and DBP by 2,0 %: from 9,7 (4,8) to 7,7 (4,7) (p = 0,032). Desynchronization of SBP and DBP rhythms were found by chronobiological analysis.

Conclusions. A prospective comparative analysis of the dynamics of ABPM in patients with HTN after COVID-19 in the conditions of the Arctic watch showed an increase in the average daily values of SBP and DBP and their daily variability, deterioration in the daily BP profile with an increase in the “night peaker” phenotype. In patients with HTN who did not have COVID-19, a prospective analysis of ABPM showed a significant increase in DBP and average daily hypertensive load of DBP, which may contribute to further cardiovascular remodeling. In patients with HTN who have recovered from COVID-19, desynchronization processes of SBP and DBP rhythms intensify, which requires an in-depth analysis of the chronobiological structure of the rhythm BP.
Quality Function Deployment: Identification of Key Parameters in Grape Growing and Wine Making
Authors: Bhanu M. Thashneem Thaqseen , Kumar Prasanna
Published: July 2024

Background: The study conducted benchmarking research, assessed and identified suitable factors for the efficient benchmarking of Karnataka wines. As the Grape Processing Industry Board is being formed by the Wine Board of Karnataka (Wine Policy ‘2007’), which may have control of grape quality, standards formulation, label approval and market promotion, the study focused on recommending strategies for quality grape-growing, wine-making for label approvals. Methods: The study adopted the Quality Function Deployment (QFD) tool to build the House of Quality to benchmark Karnataka wines with the New World wines. Result: The findings demonstrate that the informative label was given high importance by customers during wine purchases. The wine industry to meet this requirement should focus more, on the factor-crushing method of grapes. Karnataka wineries are inferior to wine from other New World regions when it comes to other aspects such as flavour, colour, brand name, grape variety, meal pairings, alcohol content, wine label designand label information.
Practice of visionary leadership in secondary schools from the perspective of teachers
Authors: Atoum Yumna , Hussein Atoom
Published: June 2024

The current study aimed to identify the degree of practicing visionary leadership in secondary school leadership from the point of view of teachers in Jerash Province. To achieve the goals of the study and answer its questions, a descriptive survey approach was used to develop the questionnaire. The study sample consisted of 315 teachers who were chosen randomly. The questionnaire was used as a study tool consisting of 31 items consisting of three areas (vision, communication vision, enabling vision) after its validity and reliability had been confirmed. The results showed that the degree of practicing visionary leadership of the secondary school leadership from the point of view of teachers in Jerash Governorate was an average degree. The current study recommended the importance of developing the visionary leadership of secondary school principals in all areas by holding specialized training courses on school leadership. This study provides a different perspective on visionary leadership among leaders in schools, as it captures teachers' perspectives on leaders' practice of visionary leadership.
Keywords: Leadership; secondary school leadership; teachers; visionary leadership.
Acute Toxicity of 70% Ethanol Extract of Kenitu (Chrysophyllum cainito L.) Leaves of Wistar Rats (Rattus norvegicus)
Authors: Maulina Novia , Fawzia Rachma Izza , Firdausy Alif Firman , Quintão Roberto Doutel , Ma'arif Burhan
Published: June 2024

The postmenopausal phase, which results in a lack of estrogen levels and is one of the triggers of menopausal symptoms, contributes to the elderly's cognitive function decline. This condition can also cause joint and bone pain, bladder and urinary tract disorders, and sexual problems. Based on several studies, it is known that kenitu (Chrysophyllum cainito L.) contains phytoestrogen compounds with a structure similar to the hormone estrogen, so kenitu has the potential as an alternative treatment for disease conditions with risk factors for estrogen deficiency. The study was conducted to determine the estimated lethal dose 50 (LD50) value based on the Globally Harmonized System (GHS) classification as well as macroscopic (physical, behavioral, and average weight gain per day) and microscopic (liver and kidney histology) values in Wistar rats against the administration of 70% ethanol extract of kenitu leaves at a dose of 2000 mg/kg body weight (BW). The Up-and-Down Procedure (UDP) acute toxicity test method was used for this study. The maximum dose was 2000 mg/kg BW of ethanol extract from 70% kenitu leaves. The study found that the 70% ethanol extract of kenitu leaves had more than 2000 mg/kg BW LD50 value against Wistar rats. Based on the classification of the GHS, it can be concluded that 70% ethanol extract of kenitu leaves against Wistar rats is classified as low toxicity.
Optimization of Temperature and Time of Ultrasonic-Assisted Extraction Method on Flavonoid and Antioxidant Activity of Brown Rice from Demak, Indonesia
Authors: Susiloningrum Dwi , Karimah Nailatul , Handayani Yanulia , Ismah Kadar , Ruas Adilson Castro , Xavier Felipe
Published: June 2024

Brown rice contains a number of bioactive components, such as pigments and flavonoids, which act as antioxidant. Plants widely distribute polar flavonoid compounds, which actively function as antioxidant. Antioxidants are substances that can significantly inhibit or prevent the oxidation of the substrate. The body requires antioxidants to defend itself against attacks by free radicals. The goal of this study was to find the best temperature and time for the Ultrasonic-Assisted Extraction (UAE) method to measure the antioxidant activity and flavonoids in brown rice extract using UV-Visible spectrophotometry. The extract was prepared using the UAE method with 96% ethanol solvent at 45°C and 55°C for 20–30 minutes. Data obtained was statistically analyzed using the one-way ANOVA test. The study found that brown rice extracted with 96% ethanol at 45°C for 20 minutes produced 4.089 mg QE (Quercetin Equivalent)/g of total flavonoids. The antioxidant activity was the lowest, with an IC50 value of 381.102 ppm. The statistical analysis using the one-way ANOVA test revealed that there were no differences in temperature or time optimization that affected the levels of flavonoids and antioxidants. It can be concluded that the 96% ethanol extract of brown rice has the best flavonoid and antioxidant content. The best treatment was at 45°C and 20 minutes of extraction time.
E-training environment for developing Capstone teaching skills for STEM teachers in Egypt
Authors: Anbar Noha , Hegazy Tarek , El Naggar Mohamed
Published: June 2024

The research investigated the efficacy of utilizing an e-training environment to enhance capstone teaching skills among STEM educators. Conducted at Obour STEM School, Cairo, Egypt, the study employed a quasi-experimental design with 27 randomly selected participants. Three instruments were utilized: a list of Capstone teaching skills, a pre-post achievement test, and an observation card assessing skill acquisition in two main fields: EDP Field and Process Management Field. These fields encompassed eight main skills, subdivided into 64 subskills. The researchers conducted pre- and post-testing, initially administering a 70-question pre-test followed by a month-long online training via Microsoft Teams. The training content aimed to address identified needs based on pre-test results. After the training, participants completed a post-test, which was repeated after another month. Results indicated a statistically significant difference (p<=0.05) between pre-test and post-achievement test scores, favoring the latter, suggesting improvement in Capstone teaching skills. Similarly, there was a significant difference (p<=0.05) between pre-test and post-observation card scores, indicating enhanced skill development. Conclusively, the study demonstrated the effectiveness of e-training, particularly employing the SOLE technique, in enhancing capstone teaching skills among STEM educators. Consequently, the researchers recommended the integration of e-training environments in STEM teacher development programs in Egypt.
Balanced Scorecard : Optimisation de la Performance dans le Secteur Public Marocain
Authors: Amine Fraine , Rajae Sabhi , Noureddine Abdelbaki
Published: June 2024

L'article analyse l'introduction de la Nouvelle Gestion Publique (NGP) au Maroc, en mettant l'accent sur la mise en œuvre du Balanced Scorecard (BSC) pour relever les défis du secteur public. Malgré les critiques sur sa standardisation, le BSC a été adopté dans le but d'instaurer une culture de la performance ; l’étude montre que le BSC a permis d'améliorer la gestion performante des organisations publiques marocaines. Grâce à une évaluation globale liant indicateurs financiers et non financiers, le BSC a favorisé une prise de décision plus éclairée. Cependant, des défis persistent, notamment la résistance au changement de la part des acteurs publics et la difficulté à définir des indicateurs de performance pertinents, l'introduction du BSC a renforcé la transparence, la responsabilisation et l'orientation stratégique, mais nécessite une formation continue du personnel et des ressources dédiées pour sa mise en œuvre. Enfin, les résultats suggèrent d'étendre l'utilisation du BSC à d'autres entités du secteur public en adoptant une approche adaptative et personnalisée afin de maximiser les bénéfices à long terme.
 
The article analyzes the introduction of the New Public Management (NPM) in Morocco, focusing on the implementation of the Balanced Scorecard (BSC) to meet the challenges of the public sector. Despite criticism of its standardization, the BSC was adopted with the aim of establishing a performance culture; the study shows that the BSC has helped to improve the performance management of Moroccan public organizations. Thanks to a global assessment linking financial and non-financial indicators, the BSC has fostered more informed decision-making. However, challenges remain, notably resistance to change on the part of public players and the difficulty of defining relevant performance indicators. The introduction of the BSC has strengthened transparency, accountability, and strategic orientation, but requires ongoing staff training and dedicated resources for its implementation. Finally, the results suggest extending the use of BSC to other public sector entities, adopting an adaptive and customized approach to maximize long-term benefits.