bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep Learning of Dark Energy Spectroscopic Instrument Mock Spectra to Find Damped Lyα Systems
Authors: Wang Ben , Zou Jiaqi , Cai Zheng , Prochaska J. Xavier , Sun Zechang , Ding Jiani , Font-Ribera Andreu , Gonzalez Alma , Herrera-Alcantar Hiram K. , Irsic Vid , Lin Xiaojing , Brooks David , Chabanier Soléne , Belsunce Roger de , Palanque-Delabrouille Nathalie , Tarle Gregory , Zhou Zhimin
Published: March 2022

We have updated and applied a convolutional neural network (CNN) machine-learning model to discover and characterize damped Lyα systems (DLAs) based on Dark Energy Spectroscopic Instrument (DESI) mock spectra. We have optimized the training process and constructed a CNN model that yields a DLA classification accuracy above 99% for spectra that have signal-to-noise ratios (S/N) above 5 per pixel. The classification accuracy is the rate of correct classifications. This accuracy remains above 97% for lower S/N ≈1 spectra. This CNN model provides estimations for redshift and H i column density with standard deviations of 0.002 and 0.17 dex for spectra with S/N above 3 pixel−1. Also, this DLA finder is able to identify overlapping DLAs and sub-DLAs. Further, the impact of different DLA catalogs on the measurement of baryon acoustic oscillations (BAO) is investigated. The cosmological fitting parameter result for BAO has less than 0.61% difference compared to analysis of the mock results with perfect knowledge of DLAs. This difference is lower than the statistical error for the first year estimated from the mock spectra: above 1.7%. We also compared the performances of the CNN and Gaussian Process (GP) models. Our improved CNN model has moderately 14% higher purity and 7% higher completeness than an older version of the GP code, for S/N > 3. Both codes provide good DLA redshift estimates, but the GP produces a better column density estimate by 24% less standard deviation. A credible DLA catalog for the DESI main survey can be provided by combining these two algorithms.
Chemotherapy Effect on Estradiol Levels in Patients with Triple-negative Breast Cancer: A Clinical Prospective Study from Indonesia
Authors: Septiani Rizka Vinkan , Soewoto Widyanti , Budhi Ida Bagus
Published: March 2022

Research Background: This study aimed to scrutinize the chemotherapy’s effect on estradiol levels in patients with triple-negative breast cancer (TNBC) at low-resource country. Methods: This prospective analytic observational cohort study involved patients with TNBC who had undergone surgery and had never received chemotherapy or hormonal therapy before. Patients were checked for estradiol levels before and after chemotherapy. This study was conducted at the Surgical Oncology Department of Regional Public Hospital Dr. Moewardi, Surakarta Indonesia, from April 2020 to March 2021. Descriptive data were presented in a frequency table based on age, menopausal status, parity status, breastfeeding status, hormonal contraception, hormonal contraception duration, family history, stage, and histological grade. Differences in estradiol changes before and after chemotherapy (mean+sd) were then reported.
Results: From a total of 23 patients, 21 patients (91.3%) experienced a decrease in estradiol levels, while two patients (8.7%) underwent an increase in serum estradiol levels after chemotherapy. The mean decrease was 11.57 pg/ml. The two samples that experienced an increase in estradiol levels had a mean increase of 16.5 pg/ml. There was a significant difference between estradiol levels before and after undergoing chemotherapy, with p-value=0.001.
Conclusions: In this research, chemotherapy reduced estradiol levels in TNBC patients. Statistically significant reductions in estradiol levels were based on the disease stage.
Utilization of Functional Instant Porridge Formulated from Taro and Purple Sweet Potato as Anti-diabetic
Authors: Mappiratu Kurniawati , Laga Amran , Sirajuddin Saifuddin
Published: March 2022

BACKGROUND: Functional instant porridge is a porridge that has undergone further processing so that when it is served, no further cooking is required.

AIM: The present study was conducted to determine the anti-diabetic, antioxidant, and anthocyanin contents of the formulation of Japanese taro flour and purple sweet potato flour.

METHODS: The materials used in this study were Japanese taro, purple sweet potato, tempeh, and celery leaves. The experimental design used was Completely Randomized Design with five treatments and two replications, and the ratio of Japanese taro flour and sweet potato flour in % (w/w) were A = 75:0, B = 50:25, C = 37.5:37.5, D = 25:50 and E = 0:75.

RESULTS: The results showed that the variations in those ratios were significantly different (p < 0.05) on the content of anti-diabetes, antioxidants, and anthocyanins. The best formulation chosen was a ratio of Japanese taro flour and purple sweet potato flour of 37.5:37.5% (w/w) (formulation C). This formulation resulted in anti-diabetic content (inhibitory of α-glucosidase enzyme of 6.149%) antioxidant IC50 of 112.86 ppm and anthocyanin content of 3.19 mg/100 g).

CONCLUSION: The most significant inhibitory activity of α-glycosidic enzyme was 43.16% in formulation E of the functional instant porridge. Moreover, the most significant antioxidant activity was 45.69% in formulation C of the functional instant porridge.
Effectiveness of Coleus Amboinicus Consumption Interventions in Increasing Breast Milk Production and Improving Maternal Health Status During COVID 19 Pandemic
Authors: Nasution Siti Saidah , Eliana Rika , Aizar Ellyta , Pramita Rianti
Published: March 2022

Insufficient milk production is a major problem for mothers who have just given birth and affects the health condition of postpartum mothers. One of the actions that can be taken to increase milk production and improve the health of postpartum mothers is to consume foods that can increase breast milk production, namely ingredients that contain galactagogue substances. Several types of herbal plants that are often consumed by postpartum mothers after giving birth to increase breast milk in North Sumatra, especially the city of Medan, are making vegetables from the bangun-bangun leaves. Bangun-bangun leaves contain the main ingredients, namely carvakrol, thymol, humulene, undecanal, terpinene, cymene, caryophyllene oxide, terpineol and salinene whose nutritional content and composition helps to stimulate breast milk production.during the Covid 19 pandemic. The intervention was carried out by giving 100 grams of bangun-bangun leaves and consumed 3 times a day starting from the time the mother gave birth until 7 days. Breast milk production was assessed from the time the first breast milk was released and the health condition of the postpartum mother was assessed by measuring vital signs and assessing health conditions while still adhering to health protocols. The study was conducted in Medan Johor, North Sumatra Province and the sample in this study consisted of 60 people consisting of 30 intervention groups and 30 control groups according to the inclusion criteria. Collecting data using a questionnaire consisting of demographic data, data on the first day of breastfeeding, and data on health conditions in postpartum mothers before and after the intervention. Data analysis was carried out using dependent and independent t-tests. The results of the study showed that there was an effect of intervention on consumption of bangun-bangun leaves on breast milk production using an independent t-test with a p value of 0.010 and an intervention for consumption of bangun-bangun leaves with postpartum mother's health condition with a p-value of 0.001. The results of this study are expected to be a solution and intervention in the care of postpartum mothers who have problems in spending milk production and are able to improve health conditions, especially during the Covid 19 pandemic.
Impact of Maternal and Neonatal Vitamin D Status on the Development of Congenital Anomalies in Egyptian Model
Authors: Mohamed Suzan Abd Razik , El Barbary Mohamed N. , Ahmed Wafaa Osman , El Maksoud Sahar S. Abd , Ibrahim Zakaria H. , Hashem Heba E. , Obaid Ahmad A. , Khalifa Mohamed , Selim Dalia
Published: March 2022

Background: Vitamin D (VD) is a remarkable problem during pregnancy. VD plays a crucial role in cellular growth and differentiation during embryogenesis. VD deficiency in pregnancy is associated with various maternal and neonatal comorbidities. 
Aim: In this study, we aimed to evaluate the potential association between maternal and neonatal vitamin D status and the subsequent development of congenital anomalies.
Patients and methods: A case-control study involving 30 mothers and their neonates born with gross structural congenital anomalies as cases and 30 mothers and their healthy neonates as controls recruited from Ain Shams University Children Hospital. Maternal and Neonatal blood samples were obtained to determine serum 25-hydroxyvitamin D.  The 25-hydroxyvitamin D concentration was stratified into a severe deficient<10ng/ml, deficient <20ng/ml, insufficient 20-29ng/ml and sufficient >30ng/ml. Status above 150ng/ml presents high risk of toxicity. 
Results: There were statistically significant differences between the two groups regarding maternal and neonatal vitamin D serum level within 29 days postpartum. Mean maternal vitamin D level in cases was 23.8ng/ml versus 42.13ng/ml in controls (P = 0,000). Mean neonatal vitamin D level in cases was 15.97ng/ml versus 28.9ng/ml in controls (P = 0,000).There was significant positive correlation between both maternal and neonatal vitamin D level with birth weight.
Conclusion: A compromised maternal vitamin D status is associated with an increased prevalence of congenital anomalies in offspring. Therefore, improvement of the periconceptional maternal vitamin D status is recommended.
CK19 and OV6 Expressions in the Liver of 2-AAF/CCl4 Rat Model
Authors: Arwinda Romy , Liem Isabella Kurnia , Fatril Ayu Eka , Oktorina Fanny , Husna Firda Asma'ul , Kodariah Ria , Wuyung Puspita Eka
Published: March 2022

BACKGROUND: Liver regeneration on a chronic liver injury with rat model research is urgent to study the pathology of human chronic diseases. 2-Acetylaminofluorene (2-AAF) and Carbon Tetrachloride (CCl4) can be applied to study about liver regeneration by liver stem cells, known as oval cells. The use of 2-AAF and CCl4 (2-AAF/CCl4) to induce chronic liver injury can lead severe hepatocyte damages and extensive fibrosis.
AIM: to observed the OV6 and CK19 expression in the liver of 2AAF/CCl4 rat model.
METHODS: In this research, a high dose of 2-AAF (10mg/kg) was applied and combined repeatedly with CCl4 (2ml/kg) for 12 weeks. An immunohistochemistry (IHC) procedure by using OV6 and CK19 antibodies was also applied to examine the regeneration of oval cells. Both antibodies expressions were then examined semi-quantitatively according to the expressions percentage of each sample based on the liver zone. We have observed the OV6 and CK19 expressions in every zone, including in portae hepatis area.  
RESULTS: The results showed that OV6 and CK19 with the highest expression in the zone I. A significant difference between OV6 and CK19 expressions was revealed in healthy (control group) and 2-AAF/CCl4 groups (both indicating p=0.045). Moreover, a ductular reaction was also found in Zone I and II of the 2-AAF/CCl4.
CONCLUSIONS: We conclude that 2-AAF/CCl4 induced chronic rat liver injury model, could be utilized to investigate the oval cells with OV6 and CK19 expression.
Current Sites of Infections and Types of Microorganisms in Patient with Febrile Neutropenia in Hematological Wards – Single Center Study
Authors: Naji Alaadin , SarKo Saman , Atta Sama
Published: March 2022

BACKGROUND: Febrile neutropenia occurs in more than 80% of patients with hematological malignances specially after chemotherapy cycles and an infectious source is identified in approximately 20–30%. Various bacterial, viral, and fungal pathogen contribute to the development of neutropenic fever and without prompt antibiotic therapy mortality rate can be as high as 70%.

AIM: The objective of the study was to document the current sites of infection in patients with febrile neutropenia in hematological ward in Baghdad Teaching Hospital, the microorganisms and antibiotic susceptibly in culture positive cases and mortality rate in 1 week and 4 weeks after episode of fever.

PATIENTS AND METHODS: One hundred cases of febrile neutropenia were evaluated in Hematological Ward of Baghdad Teaching Hospital from January 2019 to January 2020. Detailed history, physical examination, and laboratory investigations were conducted and statistical analysis of the results was done.

RESULTS: One hundred cases of febrile neutropenia, mean age of presentation was 41.56 ± 10.5 years. Acute myeloid leukemia (36%) and acute lymphocytic leukemia (26%) were the most common underlying hematological disorder, followed by Aplastic Anemia, Non-Hodgkin Lymphoma, and Hodgkin Lymphoma. Temperature ranged from 38°C to 39°C with mean temperature of 38.4°C and most of the patient presented with short duration of fever, 57% had absolute neutrophil count below 150 cells/μL with mean duration of neutropenia was 14.01 days. Respiratory tract was the most common site of infection (52%) followed by urinary tract (18%) and in 16% had no obvious focus of infection. Thirty percent of cases were culture Gram-positive and Gram-negative microorganism which were more common 62.9% which were generally sensitive to Aminoglycosides while Gram-positive microorganism constituted 29.6% of isolated bacteria and were generally sensitive to vancomycin. No mortality documented 1 and 4 weeks after fever.

CONCLUSION: We concluded that the most frequent sites of infection in patient with febrile neutropenia were respiratory tract followed by urinary tract infection, while 16% had undetermined source of infection. Thirty percent of patients had a positive blood culture with Escherichia coli being the most common infecting microorganism, Gram-negative microorganisms were more common than Gram-positive microorganism and fungal infection constituted about 6% of growth. Significant association was found between the fever and longer duration of neutropenia and the greater severity of neutropenia was observed. No mortality related to febrile neutropenia was documented.
Assessment of the Epidemiological Situation on the Dermatomycosis Incidence during Covid-19 Pandemic
Authors: Eraliyevna Amreyeva Kymbat , Meirkhankyzy Shaizadina Fatima , Meirkhanovna Zhankalova Zulfiya , Shaikhina Zhanat K. , Temiralikyzy Abuova Gaziza , Mendibay Saltanat Tanashkyzy , Maralovna Beisekova Mauza , Oryntaevna Alysheva Nessipkul , Utebayevna Shintayeva Nurzhamal , Zhienbekova Asem Zhakenovna
Published: March 2022

Абстрактный
Актуальность изучения грибковых заболеваний кожи обусловлена ​​их широкой распространенностью. Дерматомикоз поражает более 40% населения мира, в то время как онихомикоз (дерматофития ногтей), представляющая собой глобальную проблему здравоохранения, составляет около 18-40%.
Цель: Оценка эпидемиологической ситуации по заболеваемости дерматомикозами в период пандемии коронавирусной инфекции в Карагандинской области.
Материалы и методы исследования: В исследовании использовались статистические данные за период 2009-2020 гг.
Результаты: Анализ многолетней динамики заболеваемости дерматомикозами за период 2009-2020 гг. выявил неравномерность течения эпидемического процесса в Карагандинской области. Общее обилие грибов, вызывающих дерматомикозы, преобладает среди мужского населения. Анализ данных по возрасту показал, что чаще всего заболеваемость регистрировалась среди лиц до 35 лет. Дерматомикозы чаще выявляли у подростков и детей до 14 лет по сравнению со взрослыми. Анализ факторов риска развития дерматомикозов в популяции показал, что заболеваемость, связанная с грибковой инфекцией, в 59,2% случаев была обусловлена ​​контактом с животными.
Заключение . Распространенность тяжелых форм дерматомикозов среди городского населения была в 1,4 раза выше, чем среди жителей сельской местности. Мужчины болеют дерматомикозами в 1,64 раза чаще, чем женщины. Отмечены факторы, влияющие на распространение инфекционных дерматозов. Это климатические особенности центрального района республики, способствующие накоплению возбудителя в очагах инфекции, а также несвоевременное обращение за медицинской помощью, самолечение, низкая информированность о данной патологии, в частности профилактические мероприятия. .
Ключевые слова: дерматомикозы, заболеваемость, эпидемиология, распространенность, возрастные группы, население, Карагандинская область.
The Integration of Technology into Nursing Curricula: Supporting Faculty via the Technology Fellowship Program
Authors: Axley Lawrette
Published: March 2022

Computer technologies have opened the door to many new teaching approaches for nurse educators. However, the challenges facing faculty who did not ‘grow up’ in the computer age continue to be a focus of concern. The rapid expansion of electronic learning environments has increased the need to bridge the gap between the generational cohort of many educators and that of today’s learners. Teaching with technology is a learned skill, not an intuitive one; and it involves considerably more knowledge and skill than knowing how to use a computer. Programs are needed to enable faculty to incorporate technology into their repertoire of teaching strategies. The purpose of this article is to describe a Technology Fellowship Program (TFP) designed to assist faculty as they develop technological competencies to enhance their teaching skills. The article will describe one University’s initiation of a TFP, the School of Nursing’s faculty involvement in the Program, the implementation of a technology-learning project, and an evaluation that identified desirable qualities of a technology mentor, described the learning experience, and noted resources needed to increase the use of technology by faculty.
Colonialité environnementale ou internationalisme responsable ? Réflexions sur la transition écosociale depuis l’Amérique latine
Authors: Lang Miriam
Published: March 2022

L’Union européenne semble construire une nouvelle fois son Pacte vert sur le dos des pays du Sud. Sans poser la question de l’origine des ressources nécessaires au maintien et au verdissement de son économie, pas plus que celle des déchets qu’elle génère, l’Europe continue à projeter ses mirages de croissance et de technophilie au-delà de ses frontières. Plutôt qu’au maintien de ce rapport colonial aux territoires du Sud, c’est une véritable transformation de notre métabolisme social qu’il faudrait amorcer.
La crise écologique renforce la polarisation des paradigmes internationaux de l’alimentation
Authors: Cornilleau Lise , Gaudillière Jean-Paul
Published: March 2022

Avec la généralisation de l’agro-industrie, le droit à l’alimentation est devenu un enjeu de conflits majeurs au sein des institutions du système de l’ONU. Lise Cornilleau relate ici comment les organisations paysannes s’en sont saisies et ont opposé la souveraineté alimentaire et la production locale au paradigme de la sécurité alimentaire centré sur le rôle des marchés et l’expansion de l’agriculture d’exportation. Elle revient aussi sur les conséquences de la crise climatique et sur l’élargissement de ces luttes aux enjeux de la transition agro-écologique.
De la clinique des frontières au soin psychique à domicile
Authors: Blanquet Brigitte , Merucci Margherita
Published: March 2022

Les auteures, une psychanalyste et une thérapeute familiale d’orientation systémique, partent du constat que des sujets dits en situation de vulnérabilité n’accèdent pas, s’éloignent et/ou renoncent à la possibilité de bénéficier d’un accompagnement psychothérapique dans le cadre habituel des psychothérapies. Ces auteures proposent une réflexion sur les frontières, les aménagements du cadre, des dispositifs et des moyens d’intervention afin de favoriser la rencontre clinique de ces sujets et leur permettent ainsi un accès aux soins. À partir de leurs expériences cliniques au domicile de patients, c’est-à-dire auprès d’enfants, d’adolescents et de leurs familles, ces deux psychologues viennent interroger les frontières, les mouvements psychiques aux frontières que le changement de cadre rend possible. Elles placent la notion d’intimité du sujet, de son lieu de vie, de son lien à l’environnement au cœur du projet thérapeutique, tout en réalisant des ponts entre leurs deux approches épistémologiques pour penser au soin de ces patients à leur domicile 1 .
Rencontre avec un ange gardien et élaboration du deuil
Authors: Dollander Marianne
Published: March 2022

Dans cet article, l’auteure relate le suivi psychothérapique d’un patient endeuillé en proie à des idéations suicidaires, vivant en outre des expériences exceptionnelles (sous forme de dialogue avec son épouse décédée, identifiée à un ange gardien). Dans une partie théorique, elle décrit de quelle manière les conceptions sur le travail de deuil ont évolué, passant du paradigme dominant de la rupture de liens à un paradigme de la continuation des liens. Elle développe la question des sensations de présence (autrement appelées vécus subjectifs de contact avec des défunts, nécrophanies, etc.) et s’interroge sur la nature psychodynamique de l’objet « ange gardien ». Du point de vue de la prise en charge, elle démontre de quelle manière le cadre contenant de la thérapie a permis au patient de sortir de ses pulsions mortifères. Elle décrypte également les processus par lesquels le travail avec les nécrophanies de ce dernier a facilité l’élaboration de son deuil. Elle conclut sur des considérations traitant de la prise en charge des patients vivant des expériences exceptionnelles 1 .
L’invisible créativité des patients d’un centre d’accueil thérapeutique à temps partiel. La crise sanitaire entre empêchements et possibilités
Authors: Dehbi Souad
Published: March 2022

Cet article se propose, d’un point de vue psychanalytique, de rendre compte des effets de la crise du Covid-19 sur une pratique clinique au sein d’un CATTP prenant en charge principalement des patients psychotiques chroniques. Nous tenterons de montrer que la crise sanitaire a paradoxalement joué un rôle dynamisant sur le travail groupal en potentialisant la créativité des soignants et des soignés. Après avoir présenté le fonctionnement du CATTP et tenté de cerner les origines de la capacité créatrice, nous centrerons, plus spécifiquement, notre réflexion sur les fonctions thérapeutiques et la valeur testimoniale que peut avoir l’écriture dans le cadre d’un atelier d’écriture éphémère.
Construction de systèmes de croyances et controverses autour du Covid-19
Authors: Mondello Gérard
Published: March 2022

La pandémie de Covid-19 a vu émerger les opinions publiques dans la décision sanitaire publique qui l’on souvent fortement contestée. En s’appuyant à la fois sur les travaux de psychologie comportementale et de psycho-sociologie récents, ainsi que sur la théorie de l’ambiguïté, cette contribution tente d’analyser les raisons de ce doute. On distinguera deux types de patients, les « analytiques » et « intuitifs » pour expliquer les choix pour une action donnée. Cette distinction réalisée a priori n’est pas suffisante pour expliquer les choix d’un type donné car le degré d’aversion pour l’ambiguïté, l’attitude vis-à-vis de l’ambiguïté peuvent modifier ce dernier. C’est en fait la croyance dans la capacité d’un traitement de guérir par rapport à un autre qui se révèle fondamentale pour déterminer le choix pour l’un d’entre eux. JEL : I1, I18, I19, D81, L65
Le Pacte mondial sur les migrations : un pacte avec le diable ?
Authors: Labayle Henri
Published: March 2022

Le Pacte de Marrakech sur les migrations a été une source de polémiques dans le monde et l’Union européenne. Il est pourtant clair que cet instrument de « soft law » est dépourvu de force obligatoire et qu’il constitue pour l’essentiel un cadre de travail novateur.
L’armée taïwanaise au défi de l’asymétrie contre la Chine
Authors: Tierny Hugo
Published: March 2022

Les perspectives de conciliation demeurent extrêmement faibles entre la Chine et Taïwan, alors que l’écart de puissance militaire se creuse entre les deux camps. L’archipel démocratique s’adapte à la menace en déployant une stratégie asymétrique qui tire parti de ses avantages géographi­ques et de la survivabilité d’armements peu coûteux mais nombreux et effica­ces. Pour Formose, cette réforme doctrinale ferait d’une pierre trois coups en solidifiant sa posture de dissuasion conventionnelle, en rassurant les Taïwanais quant à leur capacité de se défendre et en augmentant les chances de voir les États-Unis intervenir en sa faveur en cas de conflit. Mais pour faire de ce changement une réalité, Taipei doit relever une série de défis politiques, stratégiques et opératifs.
L’audience criminelle, le masque et le corps du juge
Authors: Leclair Marie , Baffet-Lozano Virginie
Published: March 2022

En application de la loi n° 2020-856 du 9 juillet 2020 organisant la sortie de l’état d’urgence sanitaire, le port du masque a été rendu obligatoire dans tous les lieux clos 1 , en complément des gestes barrières. La mise en œuvre de cette obligation dans les salles d’audience pose d’importantes questions de métier abordées dans cet article à travers l’analyse d’une expérience de travail judiciaire sous l’angle de l’engagement du corps dans le travail vivant du juge.
Delay-induced instability and oscillations in a multiplex neural system with Fitzhugh-Nagumo networks
Authors: Ding Weijie , Mao Xiaochen , Qiao Lei , Guan Mingjie , Shao Minqiang
Published: March 2022

In this paper, we study the nonlinear dynamics of a multiplex system consisting of neuronal networks each with an arbitrary number of FitzHugh-Nagumo neurons and intra-connections and delayed couplings. The network contains an autaptic connection formed by the axon of a neuron on its own soma or dendrites. The stability and instability of the network are determined and the existence of bifurcation is discussed. Then, the study turns to validate the theoretical analysis through numerical simulations. Abundant dynamical phenomena of the network are explored, such as coexisting multi-period oscillations and chaotic responses.
Optimal strategy for a dose-escalation vaccination against COVID-19 in refugee camps
Authors: Zheng Qinyue ,   School of Management, Shandong Key Laboratory of Social Supernetwork Computation and Decision Simulation, Shandong University, Jinan, Shandong 250100, China, Wang Xinwei , Pan Qiuwei , Wang Lei ,   Department of Engineering Mechanics, Dalian University of Technology, Dalian, Liaoning 116024, China,   State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian University of Technology, Dalian, Liaoning 116024, China,   Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands,   Biomedical Research Center, Northwest Minzu University, Lanzhou, Gansu 730030, China,   School of Mathematical Science, Dalian University of Technology, Dalian, Liaoning 116024, China
Published: March 2022

An immunogenic and safe vaccine against COVID-19 for use in the healthy population will become available in the near future. In this paper, we aim to determine the optimal vaccine administration strategy in refugee camps considering maximum daily administration and limited total vaccine supply. For this purpose, extended SEAIRD compartmental models are established to describe the epidemic dynamics with both single-dose and double-dose vaccine administration. Taking the vaccination rates in different susceptible compartments as control variables, the optimal vaccine administration problems are then solved under the framework of nonlinear constrained optimal control problems. To the best of our knowledge, this is the first paper that addresses an optimal vaccine administration strategy considering practical constraints on limited medical care resources. Numerical simulations show that both the single-dose and double-dose strategies can successfully control COVID-19. By comparison, the double-dose vaccination strategy can achieve a better reduction in infection and death, while the single-dose vaccination strategy can postpone the infection peak more efficiently. Further studies of the influence of parameters indicate that increasing the number of medical care personnel and total vaccine supply can greatly contribute to the fight against COVID-19. The results of this study are instructive for potential forthcoming vaccine administration. Moreover, the work in this paper provides a general framework for developing epidemic control strategies in the presence of limited medical resources.
On function spaces related to some kinds of weakly sober spaces
Authors: Zhang Xiaoyuan ,   Department of Mathematics, Sichuan University, Chengdu 610064, China, Bao Meng , Xu Xiaoquan ,   School of Big Data Science, Hebei Finance University, Baoding 071051, China,   Department of Mathematics, Sichuan University, Chengdu 610064, China,   Fujian Key Laboratory of Granular Computing and Applications, Minnan Normal University, Zhangzhou 363000, China
Published: March 2022

In this paper, we mainly study function spaces related to some kinds of weakly sober spaces, such as bounded sober spaces, $ k $-bounded sober spaces and weakly sober spaces. For $ T_{0} $ spaces $ X $ and $ Y $, it is proved that $ Y $ is bounded sober iff the function space $ {\bf{Top}}(X, Y) $ of all continuous functions $ f : X\longrightarrow Y $ equipped with the pointwise convergence topology is bounded sober iff $ {\bf{Top}}(X, Y) $ equipped with the Isbell topology is bounded sober. But for a $ k $-bounded sober space $ X $, the function space $ {\bf{Top}}(X, Y) $ equipped with the pointwise convergence topology or the Isbell topology may not be $ k $-bounded sober. It is shown that if the function space $ {\bf{Top}}(X, Y) $ equipped with the pointwise convergence topology or the Isbell topology is weakly sober (resp., a cut space), then $ Y $ is weakly sober (resp., a cut space). Relationships among some kinds of (weakly) sober spaces are also investigated.
Growth of Bifidobacterium species is inhibited by free fatty acids and bile salts but not by glycerides
Authors: Perez-Burillo Sergio ,   Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, USA, Rajakaruna Sumudu , Paliy Oleg ,   Instituto de Nutrición y Tecnología de los Alimentos, Centro de Investigación Biomédica (CIBM), Granada, Universidad de Granada, Spain
Published: March 2022

High-fat diets have been associated with lower gut and fecal abundances of genus Bifidobacterium. Here, we investigated whether commonly consumed dietary free fatty acids have any detrimental effect on the growth of B. adolescentis, B. bifidum, and B. longum. We found that the presence of free fatty acids in the medium inhibits the growth of Bifidobacterium species to a varying degree, with capric (C10:0), oleic (C18:1), and linoleic (C18:2) acids displaying the largest effect. In comparison, free fatty acids did not affect the growth of Escherichia coli. When fats were added as a mixture of mono- and diacylglycerols, the inhibitory effect on Bifidobacterium growth was abolished.
Par volonté et par hasard
Authors: Beffa Karol
Published: March 2022

« En même temps que je commençais à m’imaginer en compositeur, je décidais de devenir musicologue. » Jamais je n’aurais pensé qu’il soit possible de dissocier composition et théorie musicale, recherche et création. Inversement, il m’était difficile d’imaginer devenir un compositeur qui ne soit pas aussi un praticien, c’est-à-dire un transmetteur : instrumentiste, mais aussi accompagnateur, improvisateur et, bien entendu, enseignant. Mon parcours ne s’est pas présenté à moi comme un effort pour affranchir, puis concilier des disciplines ou des domaines dont le cloisonnement m’étouffait. Je l’ai vécu intimement comme le déploiement naturel, logique et nécessaire d’une conception personnelle de la musique, élaborée dans un va-et-vient incessant et fécond entre la solitude du chercheur ou du compositeur et le partage avec les publics académiques ou mélomanes, ainsi qu’avec les autres arts, en particulier la littérature et le cinéma.
Ethnographie, pragmatique, histoire
Authors: Naepels Michel
Published: March 2022

Au-delà de la mise en discussion d’une certaine position théorique (pragmatique et historiciste) dans l’écriture des sciences sociales, et en particulier de l’anthropologie, le sens de cette publication ne saurait être que de marquer l’inscription du travail universitaire dans une étrange communauté, au sein de laquelle humanités et sciences sociales ne s’opposent pas, et que règlent la liberté des chemins de pensée et le goût de la transmission, par la parole et par les livres. Des lectures de Wittgenstein qu’a proposées Jean Bazin, j’ai retenu l’horizon d’une écriture déflationniste, et d’une visée déceptive relativement à nos capacités d’explication – il y a déjà tellement à faire en se donnant pour tâche de décrire notre monde de manière compréhensive. Mais c’est l’enquête ethnographique et les rencontres qu’elle m’a permis de faire qui constituent le noyau subjectif de ma réflexion épistémologique, dans la fidélité aux relations nouées avec mes amis kanaks.
MAdCAM-1 Costimulates T Cells through Integrin α4β7 to Cause Gene Expression Events Resembling Costimulation through CD28
Authors: DeBerg Hannah A , Konecny Andrew J , Shows Donna M , Lord James D
Published: March 2022

Successful treatment of inflammatory bowel disease (IBD) with the anti-integrin α4β7 mAb vedolizumab suggests that interaction of this integrin with addressin mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is central to IBD pathogenesis. Although this was presumed to be due to an inhibition of lymphocyte trafficking to the gut, as has been observed in animal models, we report no depletion of CD4 T cells from the colonic mucosa as a consequence of vedolizumab treatment in humans, regardless of efficacy. Likewise, no upregulation of alternative trafficking mechanisms was observed as a consequence of therapy to suggest that this homeostasis is maintained in patients by a mechanistic escape from inhibition. Instead, we explore a role for MAdCAM–integrin interaction as a gut-specific costimulatory signal, demonstrating that it can replace CD28 ligation to activate human T cells in vitro. This activation through integrin α4β7 is mediated through the gut-restricted molecule MAdCAM-1, and it cannot be replicated by matrix molecules or proteins that bind other integrins. A detailed analysis of mRNA expression by human T cell subsets following suboptimal TCR stimulation in the presence or absence of CD28 versus MAdCAM-1 costimulation reveals marked similarity in the effect that these two signals have upon T cells, with temporal or quantitative differences detected in the expression of cytokines associated with Th17 cells or pyogenic inflammation. Thus, we describe an alternative costimulatory pathway for T cells in the intestine, through ligation of integrin α4β7 by MAdCAM-1, which may explain the therapeutic efficacy of vedolizumab and have implications concerning the treatment of IBD.
Contribution of Protein Kinase D1 on Acute Pulmonary Inflammation and Hypersensitivity Pneumonitis Induced by Saccharopolyspora rectivirgula
Authors: Yoon Tae Won , Fitzpatrick Elizabeth A , Snyder John D , Lee Sangmin , Kim Young-In , Zacheaus Chidi , Yi Ae-Kyung
Published: March 2022

Protein kinase D1 (PKD1), a ubiquitously expressed serine/threonine kinase, regulates diverse cellular processes such as oxidative stress, gene expression, cell survival, vesicle trafficking, Ag receptor signaling, and pattern recognition receptor signaling. We found previously that exposure to hypersensitivity pneumonitis (HP) inciting Ag Saccharopolyspora rectivirgula leads to the activation of PKD1 in a MyD88-dependent manner in various types of murine cells in vitro and in the mouse lung in vivo. However, it is currently unknown whether PKD1 plays a role in the S. rectivirgula–induced HP. In this study, we investigated contributions of PKD1 on the S. rectivirgula–induced HP using conditional PKD1-insufficient mice. Compared to control PKD1-sufficient mice, PKD1-insufficient mice showed substantially suppressed activation of MAPKs and NF-κB, expression of cytokines and chemokines, and neutrophilic alveolitis after single intranasal exposure to S. rectivirgula. The significantly reduced levels of alveolitis, MHC class II surface expression on neutrophils and macrophages, and IL-17A and CXCL9 expression in lung tissue were observed in the PKD1-insufficient mice repeatedly exposed to S. rectivirgula for 5 wk. PKD1-insuficient mice exposed to S. rectivirgula for 5 wk also showed reduced granuloma formation. Our results demonstrate that PKD1 plays an essential role in the initial proinflammatory responses and neutrophil influx in the lung after exposure to S. rectivirgula and substantially contribute to the development of HP caused by repeated exposure to S. rectivirgula. Our findings suggest that PKD1 can be an attractive new molecular target for therapy of S. rectivirgula–induced HP.
Preliminary Report on the Train the Brain Project, Part I: Sensorimotor Neural Correlates of Anterior Cruciate Ligament Injury Risk Biomechanics
Authors: Grooms Dustin R. , Diekfuss Jed A. , Slutsky-Ganesh Alexis B. , Ellis Jonathan D. , Criss Cody R. , Thomas Staci M. , DiCesare Christopher A. , Wong Phil , Anand Manish , Lamplot Joseph , Simon Janet E. , Myer Gregory D.
Published: March 2022

Context

Anterior cruciate ligament injury commonly occurs via noncontact motor coordination errors that result in excessive multiplanar loading during athletic movements. Preventing motor coordination errors requires neural sensorimotor integration activity to support knee-joint neuromuscular control, but the underlying neural mechanisms driving injury-risk motor control are not well understood.

Objective

To evaluate brain activity differences for knee sensorimotor control between athletes with high or low injury-risk mechanics.

Design

Case-control study.

Setting

Research laboratory.

Patients or Other Participants

Of 38 female high school soccer players screened, 10 were selected for analysis based on magnetic resonance imaging compliance, injury-risk classification via 3-dimensional biomechanics during a drop vertical jump, and matching criteria to complete neuroimaging during knee motor tasks.

Main Outcome Measure(s)

Peak knee-abduction moment during landing was used for group allocation into the high (≥21.74 newton meters [Nm], n = 9) or low (≤10.6 Nm, n = 11) injury-risk classification (n = 11 uncategorized, n = 7 who were not compliant with magnetic resonance imaging). Ten participants (5 high risk, 5 low risk) with adequate data were matched and compared across 2 neuroimaging paradigms: unilateral knee-joint control and unilateral multijoint leg press against resistance.

Results

Athletes with high injury-risk biomechanics had less neural activity in 1 sensory-motor cluster for isolated knee-joint control (precuneus, peak Z score = 4.14, P ≤ .01, 788 voxels) and greater brain activity for the multijoint leg press in 2 cognitive-motor clusters: the frontal cortex (peak Z score = 4.71, P < .01, 1602 voxels) and posterior cingulate gyrus (peak Z score = 4.43, P < .01, 725 voxels) relative to the low injury-risk group.

Conclusions

The high injury-risk group's lower relative engagement of neural sensory resources controlling the knee joint may elevate demand on cognitive motor resources to control loaded multijoint action. The neural activity profile in the high injury-risk group may manifest as a breakdown in neuromuscular coordination, resulting in elevated knee-abduction moments during landing.
Automated static perimetry short-term learning effects in test-naive patients
Authors: Eissa Iman M.
Published: March 2022

Purpose

The aim of this study was to evaluate the intrasession learning effects in patients undergoing first-time automated perimetry.

Patients and methods

The study included 59 eyes of test-naive patients who were tested twice within a short time interval. Reliability indices, mean deviation values, visual-field index percentage, test time, scotoma size, and depth were recorded and compared between the two tests.

Results

The second test showed a statistically significant decrease in fixation losses, false-positive, and false-negative responses in about 56% of the eyes upon retesting. The mean false-positive errors were 5.4±8.7% in the first test (T1) and dropped to 1.9±2.4% in the second test (T2), a mean difference of 3.54% (P=0.002). Similarly, the mean false-negative errors dropped by 4.76% (P=0.002), and the mean fixation losses by 13.5% in T2 (P=0.000). The time taken to finish the test decreased. The scotoma size and depth improved, as well as the visual-field index and the mean deviation values.

Conclusion

Repeating a first-time test may give more reliable results even if repeated in the same session. This may be useful in the timely diagnosis and management of ophthalmic disorders in which the early therapy is an important factor as in glaucoma and neurological disorders.
Narrowband IoT: A Greener Solution for Large Scale Deployments
Authors: Routray Sudhir K. , Mohanty Sasmita
Published: March 2022

Internet of things (IoT) has become a pervasive technology with ubiquitous presence in the modern digital ecosystem. Several types of IoT are available in the recent years based on their features and applications. Narrowband IoT (NBIoT) is one of the 3GPP standardized solutions for massive machine type communications (mMTC). It is designed for the large scale mMTC to provide coverage over a large area. Therefore, NBIoT is one of the most attractive low power wide area (LPWA) technologies. It is preferred for the large scale deployments in the large projects such as smart farming, healthcare, smart cities and smart grids. However, it is also suitable for low power domestic applications such as smart home and pets’ tracking. The LPWA features of NBIoT make it the primary choice for several emerging applications such as healthcare, agriculture, utility management, tracking of objects, smart city monitoring, retail management, smart grid monitoring, and industry applications. In this article we provide the principles and applications of NBIoT for the large scale deployments.
Algorithmic Computation of the Conley Index for Multivalued Maps with No Continuous Selector in Cubical Spaces
Authors: Przybylski Mateusz
Published: March 2022

In this note we present theory which facilitates the use of Conley index algorithms for cubical multivalued maps constructed from maximal dimensional cubes in the setting when cubes of arbitrary dimension are permitted.
Rozliczenia majątkowe oraz reprezentacja jednopłciowych partnerów w związkach nieformalnych
Authors: Pytlewska Mirosława
Published: March 2022

Asset settlement and representation of same-sex partners in informal relationships The division of assets after the dissolution of a same-sex relationship generates an increasing number of problems in relation to the institutionalization of both same-sex and different-sex relationships in different EU countries. Polish law does not recognize civil partnerships or same-sex marriages. However, it has become more common for a same-sex partners from a marriage registered outside Poland to acquire rights under the rules of common marital property law in force in another country, which has legal consequences under Polish law. In practice, in day-to-day matters and in legal transactions, partners act on the basis of very specific powers of attorney, granting them a much wider range of rights than those to which spouses are authorized under the common marital property law.
TANTANGAN GURU DALAM MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH DALAM ADAPTASI PANDEMI COVID-19
Authors: Dra. Widanarti
Published: March 2022

Pandemi Covid-19 berdampak besar bagi dunia pendidikan. Perubahan sistem pembelajaran akan mempengaruhi proses pembelajaran. Pendidik di SDN PENELEH 1 SURABAYA merasakan kendala fasilitas penunjang pembelajaran online. Di masa pandemi COVID-19, keterbatasan internet dan alat komunikasi menjadi persoalan tersendiri dalam pendidikan anak negeri. Penelitian ini bertujuan untuk mengetahui strategi pengajaran, metode, hambatan dan solusi untuk memecahkan masalah selama pandemi covid19. Penelitian dilakukan melalui metode kualitatif dan melibatkan tiga guru sekolah dasar. Teknik pengumpulan data adalah observasi, wawancara dan pencatatan. Menggunakan triangulasi sumber untuk menguji keabsahan data Subyek penelitian adalah tiga orang pendidik dari SDN PENELEH 1 SURABAYA. Analisis data Miles & Huberman mencakup tiga aliran aktivitas simultan, yaitu: reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa keterbatasannya adalah kurangnya jangkauan jaringan smartphone, internet, TV dan radio, keterbatasan bahan ajar, jarak dari rumah siswa, disiplin siswa, keterbatasan dan keterbatasan waktu bagi orang tua untuk menemani anaknya belajar. Strategi pemecahan masalah guru meliputi penerapan blended learning, membuat kelompok belajar, mengunjungi siswa secara teratur, bekerja sama dengan orang tua, menyesuaikan rencana pembelajaran, mengoptimalkan media elektronik, dan menggunakan media kreatif. Oleh karena itu, kemampuan memecahkan masalah sangat penting bagi pendidik.
THỰC TRẠNG VÀ MỘT SỐ GIẢI PHÁP CƠ BẢN NHẰM NÂNG CAO HIỆU QUẢ GIẢNG DẠY CÁC MÔN LÝ LUẬN CHÍNH TRỊ TẠI TRƯỜNG ĐẠI HỌC CÔNG NGHIỆP THÀNH PHỐ HỒ CHÍ MINH
Authors: NGUYỄN TRUNG DŨNG
Published: March 2022

Trong nhiều năm qua, chất lượng giảng dạy các môn lý luận chính trị (LLCT) ở trường Đại học Công nghiệp Thành phố Hồ Chí Minh (ĐHCN TP.HCM) từng bước được cải thiện và nâng cao. Trình độ giảng viên không ngừng được nâng lên, phương pháp giảng dạy theo hướng tích cực luôn được quan tâm, đổi mới, đa số sinh viên hứng thú với các học phần LLCT, kết quả phản hồi của sinh viên về môn học đạt kết quả tốt. Tuy nhiên, bên cạnh đó, chất lượng, hiệu quả giảng dạy các môn LLCT tại trường ĐHCN TP.HCM chưa đạt kết quả như kỳ vọng, chưa tương xứng với nỗ lực và tâm huyết của giảng viên, tỷ lệ sinh viên tổng kết các môn LLCT đạt dưới trung bình còn cao, tỷ lệ sinh viên đạt kết quả khá, giỏi thấp, sinh viên thụ động trong việc học tập, hình thức kiểm tra, đánh giá lạc hậu, chưa phù hợp với yêu cầu đổi mới, dẫn đến xuất hiện tình trạng sinh viên học vẹt, học tủ, sử dụng tài liệu trong thi cử, đánh giá,… Bài viết nhằm đánh giá đúng thực trạng công tác tổ chức giảng dạy các môn LLCT tại trường ĐHCN TP.HCM, qua đó đề xuất các giải pháp nhằm nâng cao hiệu quả giảng dạy đối với các môn học này, đáp ứng tầm nhìn và sứ mạng của nhà trường đặt ra.
MỘT SỐ VẤN ĐỀ PHÁP LÝ VỀ CĂN HỘ KHÁCH SẠN TẠI VIỆT NAM HIỆN NAY – THỰC TRẠNG VÀ HƯỚNG HOÀN THIỆN
Authors: ĐẶNG CÔNG TRÁNG
Published: March 2022

Hơn ba mươi năm kể từ khi Việt Nam chính thức hội nhập vào nền kinh tế thế giới, một trong những hình ảnh thể hiện rõ nét sự hội nhập đó chính là sự hình thành và phát triển của thị trường bất động sản ở Việt Nam. Tuy mới hơn hai mươi năm chính thức hình thành nhưng thị trường bất động sản Việt Nam đã bắt kịp với thị trường bất động sản của thế giới từ các loại hàng hóa đến các loại hình dịch vụ của thị trường này. Bên cạnh những loại hàng hóa truyền thống của thị trường bất động sản như nhà ở, văn phòng làm việc, trung tâm thương mại, đất nền thì ở thị trường bất động sản Việt Nam đã xuất hiện những loại hàng hóa mới mà vốn dĩ là đã xuất hiện từ lâu trong thị trường bất động sản trên thế giới, đó là loại hàng hóa mang tên: căn hộ khách sạn (condotel) và căn hộ văn phòng (officetel). Sự xuất hiện những mặt hàng này theo kịp với thế giới nhưng lại đi trước sự điều tiết quản lý của nhà nước mà trong đó cụ thể là thiếu vắng hành lang pháp lý để quản lý đối với hai mặt hàng mới này trong thị trường bất động sản, đã gây ra nhiều khó khăn cho các chủ thể tham gia vào thị trường bất động sản dẫn đến những hệ lụy làm ảnh hưởng đến sự phát triển ổn định và bền vững của thị trường bất động sản Việt Nam. Vì vậy, phạm vi bài viết này muốn trình bày một số vấn đề pháp lý liên quan đến mặt hàng mới trong thị trường bất động sản Việt Nam là condotel, nhằm góp phần hoàn thiện khung pháp lý về kinh doanh bất động sản ở Việt Nam.