bluuebunny/crossref_metadata_2025 huggingface dataset:
STUDY OF THE CHEMICAL COMPOSITION OF STACHYS PALUSTRIS L. ESSENTIAL OIL PRODUCING IN THE ASTRAKHAN REGION
Authors: Velikorodov Anatoliy Valeriyevich , Laktionov Aleksey Pavlovich , Nosachev Svyatoslav Borisovich , Morozova Lyudmila Viktorovna , Nosacheva Tat'yana Aleksandrovna
Published: May 2023

Samples of essential oil from the ground part of Stachys palustris L., which grows wild in the Astrakhan region, were obtained by hydrodistillation, and the dependence of its yield on the growing season of the plant was studied. The duration of the hydrodistillation process was set experimentally to study the dynamics of changes in the results of essential oil over time. The yield of essential oil is observed in % when converted to the weight of absolutely dry raw materials. The highest yield of essential oil was obtained from plants in the flowering phase (0.19–0.20%). Quantitative analysis of the main components of Stachys palustris L. essential oil was carried out by GC-MS method. The quantitative content of essential oil components was calculated from the areas of gas chromatographic peaks without using correction factors. It was found that the composition of the essential oil of Stachys palustris L. was very specific. 47 compounds belonging to various classes have been identified. It has been established that the composition of the essential oil of the Stachys palustris L. is very specific. 47 compounds corresponding to the class were identified. Compound classes include fatty acids and acid esters (36.23%), carbonyl compounds (14.25%) and oxygenated basic sesquiterpenes (12.90%), phenols (5.85%). Among the sesquiterpenoids, the predominant component of the essential oil is hexahydrofarnesylacetone (7.5%). The oil also contains (Z)-phytol (6.78%), thymol (4.2%), β-ionone (3.36%) and β-caryophyllene (2.87%). Nonspecific components of the essential oil of the taxon Stachys palustris growing in the Astrakhan region are coumarin (10.27%) and coumaran (0.36%).
BIOCONVERSION OF SEA BUCKTHORN MEAL INTO PHYSIOLOGICALLY ACTIVE INGREDIENTS
Authors: Averyanova Elena Vitalievna , Shkolnikova Marina Nikolayevna , Rozhnov Evgeny Dmitrievich , Batashov Evgeny Sergeevich
Published: May 2023

This article shows the main directions of industrial processing of sea buckthorn fruits: obtaining oil and oil extracts, juice and its concentrates, dry and thick extracts. The article presents information about sea buckthorn, which grows throughout the Siberian region and is an insurance raw material for the region's economy. A description of the properties of this shrub depending on the geographical location and soil and climatic conditions is given, which served as the basis for compiling the characteristics of intensive varieties of Siberian sea buckthorn and considering the directions of processing depending on the composition. It has been established that a large-tonnage waste - defatted meal containing a significant amount of biologically active substances, is not subjected to deep processing, having a good industrial potential. The chemical composition of the sea buckthorn meal of the Altai selection, the extractive substances of which contain organic acids, sugars, vitamins, phenolic, pectin and mineral substances, has been studied. The role of bioflavonoids as the largest group of natural phenolic substances for maintaining human health is noted in view of their high and multidirectional biological activity. The aim of the work was to find an effective way to utilize defatted sea buckthorn meal into a complex of phenolic substances with the possibility of implementation in the conditions of industrial production in Siberia. It has been established in the experiment that the intensification of the technological process for obtaining a complex of bioflavonoids using enzymatic lysis of raw materials and ultrasonic treatment at the stage of extraction of fermented sea buckthorn meal makes it possible to reduce the extraction time from 1.5 h to 15 min with an increase in the yield of the target product by 27%. The possibility of industrial application of the developed technology is determined, the cost price of the complex of bioflavonoids is predicted. Directions for the use of individual flavonoids, which are part of the complex, as physiologically active ingredients have been established. It is shown that the application of the developed technology is possible not only in Siberia, but also in those regions of the Russian Federation where there are industrial plantations and natural thickets of sea buckthorn bushes.
USING TANGERINE PEEL AS A SORPTION MATERIALS TO REMOVING POLLUTANTS FROM WATER ENVI-RONMENTS
Authors: Shaikhiev Il'dar Gilmanovich , Sverguzova Svetlana Vasil'yevna , Shaikhieva Karina Il'darovna , Cisse Khadim , Voronina Yuliya Sergeyevna
Published: May 2023

The literature data on the use of agricultural waste, mandarin peel (Citrus reticulata) as a sorption material for the removal of various pollutants, mainly metal and metalloid ions and dyes from aqueous media, are summarized. The review, based on the analysis of various literary sources, provides information on the volume of waste generation from the processing of citrus fruits, including tangerines. Information is given on the content of various chemical compounds in the composition of tangerine peel. Ways of using mandarin peel in various branches of industrial production are shown. Information on the values ​​of the maximum sorption capacity of the peel of tangerines for pollutants is given. It has been determined that adsorption isotherms of various pollutants by tangerine peel are in most cases described by the Langmuir model, and the kinetics of the process in most cases corresponds to a pseudo-second order model. The possibility of obtaining carbonizates and activated carbons from the peel of Citrus reticulate and the use of the latter as sorbents of heavy metal ions and dyes from aqueous media is shown. It is shown that it is possible to increase the sorption parameters of tangerine peel powder and carbonizates for various pollutants by chemical modification with various reagents.
Role of Phytochemicals in Neurological Disease Management
Authors: Chauhan Shalu , Gupta Dr Girish , Srivastava Dr. Vivek , Garg Mr Suresh
Published: May 2023

Neuro degeneration is the umbrella term for the progressive loss of structure and function of neurons, including death of neurons. Many neurodegenerative diseases including Parkinson‘s, Alzheimer‘s, and Huntington‘s occur as a result of neurodegenerative processes. As research progresses, many similarities appear which relate these diseases to one another on a sub-cellular level

The greatest risk factor for neurodegenerative diseases is aging. Mitochondrial DNA mutations as well as oxidative stress both contribute to aging. Protein degradation offers therapeutic options both in preventing the synthesis and degradation of irregular proteins.

Currently, there is no cure for Alzheimer's. But drug and non-drug treatments may help with both cognitive and behavioural symptoms. Researchers are looking for new treatments to alter the course of the disease and improve the quality of life for people with dementia.

The developed drug product is a unique formulation derived from botanical source, globally patent protected formulation, safety profile evaluated on patient, efficacy profile evaluated on patient, efficacy evaluated against Donazapril and tacrine. Based on clinical data the drug product is recommended for the prevention and management of neurodegenerative disorder.

Botanical products are finished, labeled products that contain vegetable matter as ingredients. The drug product Neuro-BDH tablets contain drug substance derived from botanical sources. The drug substance is standardized extract of herbs. Using commonly used excipients drug product was formulated as immediate release oral tablet. This pharmaceutical development report describes the details of development studies.
Diabetes mellitus and long-time outcomes of autovenous femoro-popliteal bypass
Authors: Artemova A. S. , Chernyavskiy M. A.
Published: May 2023

BACKGROUND: the effect of diabetes mellitus on the long-term patency of autovenous femoro-popliteal bypass has not been definitively determined AIM: to determine the effect of diabetes mellitus on the long-term outcomes of autovenous femoral-popliteal bypass.

MATERIALS AND METHODS: the results of treatment of 648 patients who underwent autovenous femoral-popliteal bypass were analyzed. The patients were divided into 2 clinical groups: the first group included 367 patients with diabetes mellitus, the second — 281 patients without the named disease. The groups did not differ significantly in the incidence of concomitant pathology.

RESULTS: occlusion of the autovenous conduit within a 5-year period after surgical treatment was observed in 218 patients of the first group (59.4%) and 72 patients of the second group (25.6%) (p <0.01, χ2 = 39.05, RR = 1.78; CI = 1.53–2.12). The average service life of the autovenous femoral-popliteal bypass was 63.49 months in patients of the first group, and 107.46 months in the second. The decompensated course of diabetes mellitus was observed in 203 patients (55.2%). Among patients with decompensated diabetes mellitus, occlusion of the autovenous femoral-popliteal bypass was observed in 95 patients (46.8%), in 104 patients the autovenous conduit was passable (51.2%; p = 0.449, χ2 = 0.57). Decompensated course of diabetes mellitus may contribute to a decrease in the service life of autovenous femoro-popliteal bypass.

CONCLUSION: the presence of diabetes mellitus, and especially its decompensated course, can negatively affect the patency of autovenous femoro-popliteal bypass in the long term.
Association of carotid atherosclerosis and peripheral artery disease in patients with type 2 diabetes: risk factors and biomarkers
Authors: Koroleva E. A. , Khapaev R. S. , Lykov A. P. , Korbut A. I. , Klimontov V. V.
Published: May 2023

BACKGROUND: Carotid atherosclerosis (CA) and lower extremity peripheral artery disease (PAD) is a common and potentially life-threatening comorbidity in diabetes.

AIM: to determine risk factors and biomarkers of the association of CA and PAD in patients with type 2 diabetes.

MATERIALS AND METHODS: A single-center cross-sectional comparative study was carried out. Three hundred ninety one patients with type 2 diabetes were included. Duplex ultrasound of carotid and low limb arteries, screening/monitoring of diabetic complications and associated diseases, and assessment of glycemic control, biochemical and coagulation parameters were performed. Factors involved in vascular wall remodeling, including calponin-1, relaxin, L-citrulline, matrix metalloproteinase-2 and -3, were measured in blood serum by ELISA.

RESULTS: The signs of CA and PAD were observed in 330 and 187 patients respectively. In 178 patients, both CA and PAD were revealed. The risk of combined involvement of carotid and lower extremity arteries was higher in patients with diabetic retinopathy (OR=2.57, p<0.001), chronic kidney disease (OR=4.48, p<0.001), history of myocardial infarction (OR=5.09, p<0.001), coronary revascularization (OR=4.31, p<0.001) or cerebrovascular accident (OR=3.07, p<0.001). In ROC-analysis, age ≥65.5 years (OR=3.43, p<0.001), waist-to-hip ratio ≥0.967 (OR=3.01, p=0.001), diabetes duration ≥12.5 years (OR=3.7, p<0.001), duration of insulin therapy ≥4.5 years (OR=3.05, p<0.001), duration of arterial hypertension ≥16.5 years (OR=1.98, p=0.002), serum L-citrulline ≥68 µmol/l (OR=3.82, p=0.003), and mean amplitude of glucose excursions ≥3.72 mmol/l (OR=1.79, p=0.006) were the risk factors for atherosclerosis of two vascular beds. In multivariate logistic regression analysis, age, diabetes duration and waist-to-hip ratio were independent risk factors for association of CA and PAD (p=0.005, p=0.0003, and p=0.004 respectively).

CONCLUSION: In subjects with type 2 diabetes, carotid and lower extremity atherosclerotic disease is associated with age, diabetes duration, abdominal obesity, microvascular and macrovascular complications, glucose variability, and high serum levels of L-citrulline.
On the 100th anniversary of the Nobel Prize «For the Discovery of Insulin»
Authors: Magerramova S. T. , Odarchenko A. S. , El-Taravi Y. A. , Erikenova D. K. , Shestakova M. V.
Published: May 2023

The condition known today as diabetes mellitus was described as early as 1550 B.C. in the papyrus of Ebers, when Ayurvedic physicians noted the sweet taste of urine in patients with polyuria. This fact allows diabetes to be considered as one of the most well-known antiquity diseases. During all these thousands of years scientists have been trying to «unravel» this «mysterious» condition, and to find the cause and ways to cure the disease. Therefore, the long history of the diabetes existence is rich in discoveries, which often had a tremendous impact on all medicine. Insulin discover and investigation has become a key moment in diabetes history. A lot of scientists who have worked on the study of the insulin structure and developed new methods have been honored with the Nobel Prize. In our opinion, this review highlights the most important works of the 20th century, which played a key role in the discovery of a drug for the treatment of diabetes mellitus patients.
Reduction in cardiovascular disease events in patients with type 2 diabetes mellitus treated with a sodium–glucose cotransporter 2 inhibitor versus a dipeptidyl peptidase-4 inhibitor: A real-world retrospective administrative database analysis in Japan
Authors: Kashiwagi A. , Shoji S. , Onozawa S. , Kosakai Y. , Waratani M. , Ito Yu.
Published: May 2023

AIMS/INTRODUCTION: To evaluate the benefit of sodium–glucose cotransporter 2 inhibitors (SGLT2i) versus dipeptidyl peptidase-4 inhibitors (DPP4i) in reducing cardiovascular disease (CVD) events in patients with type 2 diabetes mellitus with and without a CVD history.

MATERIALS AND METHODS: This retrospective cohort study used Japanese hospital administrative data from the Medical Data Vision database (January 2015 to April 2020). Patients with type 2 diabetes mellitus (n=625,739) who were new users of an SGLT2i (n=57,070; 9.1%) or DPP4i (n=568,669; 90.9%) were included. Outcomes included hospitalization for heart failure (hHF), all-cause death (ACD) and the composite of hHF or ACD. Hazard ratios (HR) were calculated using the inverse probability weighting Cox proportional hazards model to compare CVD event risks between treatment groups.

RESULTS: Compared with DPP4i, SGLT2i was associated with a significant reduction in hHF risk among patients without a CVD history (HR 0.507, 95% confidence interval 0.283–0.907), but not in the full cohort or those with a CVD history. SGLT2i was associated with a significant risk reduction of ACD (HR 0.592, 95% confidence interval 0.481–0.729) and the composite of hHF or ACD (HR 0.712, 95% confidence interval 0.613–0.826), compared with DPP4i in the full cohort; similar results were observed among patients with and without a CVD history.

CONCLUSION: In this real-world study, SGLT2i versus DPP4i was associated with a significant reduction in hHF, ACD and hHF or ACD events in patients with type 2 diabetes mellitus without a CVD history.
The advisory board resolution on the use of sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists in type 2 diabetes
Authors: Antsiferov M. B. , Galstyan G. R. , Demidova T. Yu. , Zilov A. V. , Markova T. N. , Mkrtumyan А. M. , Petunina N. A. , Khalimov I. S. , Shamkhalova M. S. , Shestakova M. V.
Published: May 2023

Type 2 diabetes is characterized by increasing incidence and prevalence all-over the world. Current therapeutic management of type 2 diabetes is complex and is based not only on glycemic control, but also on cardiovascular and renal risks reduction. In previous years the use of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1 RA) increased in Russian Federation. Some manufacturers of the most widely used GLP-1 RA reported the supply decline in several countries. On Advisory board with participation of the Russian Endocrinology Association members the topics of SGLT2i and GLP-1 RA use in type 2 diabetes were discussed. The experts made conclusion that the decrease in access to GLP-1 RA does not pose serious risk for treatment of type 2 diabetes patients. SGLT2i show benefits in risk reduction of HF and CKD progression compering to GLP-1 RA, and in general show comparable efficacy in risk reduction of ACVD outcomes.  SGLT2i show less glycemic efficacy in comparison with GLP-1 RA, and their replacement may need adding antidiabetic agents from other groups.
Diabetes mellitus in the Russian Federation: dynamics of epidemiological indicators according to the Federal Register of Diabetes Mellitus for the period 2010–2022
Authors: Dedov I. I. , Shestakova M. V. , Vikulova O. K. , Zheleznyakova A. V. , Isakov M. A. , Sazonova D. V. , Mokrysheva N. G.
Published: May 2023

BACKGROUND. The clinical and epidemiological characteristics of diabetes mellitus (DM) and the quality of its therapy are the key prognostic dominant that determines the organizational aspects of the diabetic service. The continuous dynamic   monitoring of DM has been carried out in the Russian Federation (RF) since 1996 through the activities of the Federal Register of Diabetes Mellitus (FDR).

AIMS. The aim of our study was to analyze the epidemiological characteristics of DM in the RF (prevalence, morbidity, mortality), the prevalence diabetic of complications, the state of carbohydrate metabolism (level of HbA1c) and the dynamics of the structure of glucose-lowering therapy (GLT) according to the FDR.

MATERIALS AND METHODS. The database of FRD (https://www.diaregistry.ru/), 85 regions of the RF. The data are presented as of 01.01.2023 and in dynamics for the period 2010–2022.

RESULTS. The total number of DM patients in the RF as of 01.01.2023 was 4 962 762 (3.31% of the population), including: Type 1 (T1) — 5.58% (277.1 ths), T2 — 92.33% (4.58 million), other DM types —2.08% (103 ths). The dynamics of prevalence over the 13-year period (2010→2022) was 146.0→191.0/100 ths people with T1, and 2036.2→3158.8/100 ths people with T2; morbidity in T1 12.3→8.2/100 ths population, in T2 260.1→191.4/100 ths population; мortality: T1 2.1→2.4/100 ths population, T2 41.2→86.1/100 ths of the population. The main cause of death was cardiovascular: in T1 38.6% cases, in T2 — 50.9%. Life expectancy (average age of death of patients): T1 was 52.7 years, the dynamics in males 50.9 → 50.7 years, females 62.1→56.0 years; in T2 — 74.2 years, males 69.5→70.4 years, females 74.2→76.1 years. The dynamic of DM duration from onset to the death: in T1 15.4→19.9 years; in T2 11→11.4 10.2→11.8 years. The proportion of patients with laboratory-measured HbA1c <7% in the dynamics of 2010–2022: with DM1 24.4%→29%, with DM2 41.5%→42.2%, with HbA1c ≥9.0%: with DM1 29, 4% → 20.4%, with DM2 13.8 → 9.0%.The incidence of diabetic complications as of 01.01.2023 in T1 and T2 patients: neuropathy 41.3% and 23.7%, nephropathy (CKD) 22.8% and 19.1%, retinopathy 28.9% and 12.3%, respectively. The structure GLT in T2 patients as of 01.01.2023: monotherapy — 41.6%; combination of 2 GLM — 30.0%, 3 GLM — 5.8%, insulin therapy in 18.3%.

CONCLUSIONS. The information-analytical system FDR is a key tool for systematizing the most important epidemiological and clinical characteristics of DM based on data from real clinical practice, which allows optimizing the algorithm of patient management and improving the quality of care for diabetes.
''DISSEMINATION OF KNOWLEDGE PROMOTES ADVANCES IN NURSING AND STRENGTHENS PROFESSIONAL ORGANISATION'': A BIBLIOMETRIC ANALYSIS OF THE SLOVENIAN NURSING REVIEW (2015-2020)
Authors: Prosen Mirko , Lorber Mateja ,   University of Maribor, Faculty of Health Sciences, Kocbek Gajšt Martina ,   Charles University, The Institute of the History of Charles University and Archive of Charles University, Ličen Sabina
Published: May 2023

Introduction: The Slovenian Nursing review is the main Slovenian scientific journal in the field of nursing and midwifery. Over the years, it has made a significant contribution to the dissemination of knowledge in this field and has had a significant impact on the professionalization of both professions. The journal has established international standards in the field of publishing and has been included in several international databases over the years. The aim of this study, which is part of a large-scale study, was to examine the characteristics of the journal in the period 2015-2020. Methods: A bibliometric analysis of the journal's publications between 2015-2020 was performed. Data were collected partly manually and partly obtained from the Open Journal Systems platform used by the journal. The analysis was done using SPSS version 26 and VOSviewer. Results: The study showed a steady trend in the number of papers, with the lowest number in 2018 (n = 24). Of the 157 papers, 99 were original scientific papers. The thematic analysis showed that the topics corresponded to the basic objectives of the journal, but the most frequent topic was related to nursing education. The most frequent keywords were 'nursing', 'health', 'care' and 'education'. Of all the authors, most were from Slovenia (n = 146) and the first author was most often female (n = 123). Discussion and conclusion: Research in nursing and midwifery is crucial for the development of evidence-based practice. At the same time, it is of paramount importance that scientific evidence is accessible in the mother tongue. The Slovenian Nursing Review provides nurses and midwives with high quality evidence that is generated in their own cultural context and contributes to more informed decision-making and guides nursing and midwifery practice.
MANAGING THE QUALITY OF NURSING AND SOCIAL CARE IN SENECURA GROUP HOMES FOR THE OLDER ADULTS
Authors:   SeneCura Kliniken und Heimebetriebsgesellschaft m.b.H, Vienna, Austria, Halbwachs Helena Kristina
Published: May 2023

Effective quality management is a key element in ensuring the safety of residents and the high quality of nursing and social care services in long-term care facilities. It requires a systematic and holistic approach, as quality management consists of many interdependent and interrelated elements. This paper presents case strudy - the quality management of nursing and social care in the SeneCura group of nursing homes. Quality management is carried out with support of the parent headquarters, by professional quality managers closely liaising with the management of the nursing homes. Comprehensive quality management consists of risk management, monitoring feedback, surveying residents and staff, monitoring training activities, monitoring a wide range of quality indicators, providing guidelines, standards and policies, and monitoring compliance and adherence to these documents through internal controls and other methods. An important activity of the central quality function and of the management as a whole is to create and maintain a culture of safety, where there is no fear of reprisals for failures Unfortunately, it is not possible to compare the indicators and the effectiveness of quality management in long-term care in the Slovenian context, as there is no consensus at the moment to make the data comparable and transparent. This makes the exchange of experience and good practice all the more important
AN INNOVATIVE APPROACH TO THE PROMOTION OF THE HEALTH CARE ASSISTANT PROFESSION
Authors:   Murska Sobota General hospital, Kreft Nataša , Jerebic Bojana ,   Murska Sobota General hospital
Published: May 2023

Healthcare organisations worldwide have faced lack of nursing personnel in recent years. Health care assistant as profession has been primarily promoted by educational institutions, however they no longer suffice present demand. Therefore, healthcare workers encourage the young, primarily to choose the career of health care assistant and possible continuation of education at the undergraduate nursing program. At General Hospital Murska Sobota we produced a short film as an innovative approach to promote the profession in order to acquaint the young, who are still uncertain of their career, with everyday work of health care assistant at various hospital departments. We invited students at Secondary School of Nursing Murska Sobota to partake in the film, which resulted in their active involvement. The film is displayed at information days at previously mentioned school and at the “job market” organised by primary schools at Pomurje region. The film is very well accepted and aids the young who have not yet chosen their career path. Our vision is to approach the promotion of the career of health care assistant ourselves since determination of career is one of the most significant decisions in a lifetime and to encourage the youth to choose the career of future nursing profession.
Pengaruh perendaman ekstrak daun pepaya (Carica papaya L.) terhadap daya tetas telur ikan bandeng (Chanos chanos)
Authors: Mahendra Rais , Susilowati Titik , Prayitno Slamet Budi
Published: May 2023

Ikan bandeng termasuk komoditas penting karena memiliki nilai ekonomis cukup tinggi, rasa yang enak, harga terjangkau dan dapat dibudidayakan secara polikultur sehingga banyak yang melakukan budidaya ikan bandeng. Penetasan telur pada produksi nener penting dilakukan karena untuk menunjang ketersediaan benih ikan bandeng. Pemberian ekstrak daun pepaya pada telur ikan bandeng dapat mencegah timbulnya jamur, bakteri dan penyakit yang menempel pada telur ikan bandeng sehingga daya tetas telur ikan bandeng dapat meningkat, selain itu penggunaan daun pepaya juga tidak mengakibatkan residu terhadap lingkungan. Penelitian ini bertujuan untuk mengetahui dosis terbaik ekstrak daun pepaya terhadap daya tetas telur dan tingkat kelulushidupan larva ikan bandeng.Penelitian ini dilaksanakan pada tanggal 22 Maret – 13 April 2021 di Hatchery Balai Besar Perikanan Budidaya Air Payau, Jepara, Jawa Tengah. Bahan uji yang digunakan adalah daun pepaya, etanol dan telur ikan bandeng yang berasal dari Balai Besar Perikanan Budidaya Air Payau (BBPBAP) Jepara. Metode yang digunakan adalah eksperimen dengan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan masing-masing 3 ulangan dengan dosis perendaman ekstrak daun pepaya yang berbeda. Perlakuan A (tanpa pemberian ekstrak daun pepaya), B (perendaman telur dengan konsentrasi 2 ml), C (perendaman telur dengan konsentrasi 4 ml) dan D (perendaman telur dengan konsentrasi 6 ml). Waktu perendaman adalah 5 menit Hasil penelitian menunjukkan bahwa pengaruh perendaman telur dengan ekstrak daun pepaya terhadap daya tetas telur dan kelulushidupan larva ikan bandeng berpegaruh nyata (P<0,05) terhadap HR dan SR. Dosis terbaik perendaman telur dengan ekstrak daun pepaya terhadap daya tetas telur dan kelulushidupan larva ikan bandeng adalah 4 ml (perlakuan C) yang menghasilkan HR (84.88±1.03) % dan SR (82.86±2.34) %.Kata kunci : ekstrak daun pepaya; daya tetas; kelulushidupan; Chanos chanos
PENGARUH LAMA PERENDAMAN LARUTAN EKSTRAK DAUN BELIMBING WULUH (Averrhoa bilimbi) terhadap DAYA TETAS TELUR IKAN MAS (Cyprinus carpio).
Authors: Amalia Yolanda Rizki , Yuniarti Tristiana , Basuki Fajar
Published: May 2023

Salah satu kendala yang sering dihadapi oleh pembudidaya ikan mas dalam usaha pembenihannya adalah derajat penetasan telur masih rendah yaitu 32,67% (Setyono, 2009). Hal ini disebabkan karena telur ikan mas yang bersifat adhesif telur saling menempel dengan lendir yang lengket dan menutupi seluruh permukaan telur. Gumpalan telur dan lendir dapat menghambat masuknya oksigen sehingga, perkembangan telur terhambat yang mengakibatkan daya tetas telur ikan mas rendah. Salah satu solusi untuk mengatasi hal tersebut adalah dengan merendam telur menggunakan larutan daun belimbing yang mempunyai kandungan zat tanin berperan dapat mengurangi lendir yang menghambat proses respirasi dan dapat mempercepat proses penetasan telur ikan mas.Penelitian ini dilaksanakan pada bulan Mei-Juni 2021 di Balai Benih Ikan (BBI) Mijen, Semarang, Jawa Tengah. Telur uji yang digunakan untuk penelitian berasal dari pemijahan buatan. Metode penelitian yang digunakan adalah metode ekperimental denga Rancangan Acak Lengkap (RAL) yang terdiri dari 4 Perlakuan dan 3 ulangan. Perlakuan yang dilakukan yaitu perendaman dengan larutan ekstrak daun belimbing wuluh 4ml/L  selama A (0 menit), B (5 menit), C (10 menit) dan D (15 menit). Data yang dikumpulkan meliputi daya tetas telur, survival rate dan kualitas air. Hasil dari penelitian lama perendaman dengan menggunaka larutan ekstrak daun belimbing wuluh berpengaruh nyata (P<0,05) terhadap daya tetas telur ikan mas. Perlakuan C dan D memberikan hasil yang sama pada daya tetas telur dan survival rate. Daya tetas telur pada perlakuan C (10 menit) yaitu 76,67±2,31% dan perlakuan D (15 menit) yaitu 79,33±2,31%. Survival rate perlakuan C yaitu 71,24±3,85% dan D yaitu 73,11±3,85%. Nilai kualitas air masih dalam kisaran layak yaitu DO pada kisaran 5,0-6,2 mg/L. Suhu pada kisaran 26,0oC - 28,6oC dan pH yaitu 8.
Estrutura da comunidade de plantas daninhas nativas e exóticas invasoras em áreas de plantio de mandioca
Authors: De Andrade Mendonça Diego , Targino de Araújo Kelianne Carolina , Santos Cruz Anny Bianca , Santos Almeida Thieres , Fabricante Juliano Ricardo
Published: May 2023

As plantas daninhas são responsáveis por diminuir a produtividade de diferentes culturas agrícolas. Em razão da importância do tema, o objetivo da presente pesquisa foi avaliar como a comunidade de plantas daninhas nativas e exóticas invasoras está estruturada em áreas de plantio de mandioca em propriedades rurais na região de Itabaiana, SE. Para tanto, foram selecionadas cinco áreas e amostradas 10 parcelas de 1 m² em cada área. Nas unidades amostrais foram contabilizados todos os indivíduos de cada espécie presente e para a avaliação da cobertura das espécies, as parcelas foram divididas em 100 subparcelas de 10 cm x 10 cm. Foram computados o número de subparcelas preenchidas por cada espécie. Foram calculados os parâmetros fitossiciológicos usuais e foram realizadas as demais análises (diversidade, equabilidade, similaridade, dissimilaridade, ANOSIM e NMDS). No total foram amostrados 8157 indivíduos, distribuídos em 58 espécies. Destas, 46 eram nativas e 12 eram exóticas invasoras. A espécie nativa com maior valor de importância (VI = 50,65) foi Urtica dioica e a exótica invasora (VI = 18,91) foi Dactyloctenium aegyptium. As espécies exóticas invasoras representaram 9,12% da densidade observada nas parcelas. Nas análises de similaridade, dissimilaridade e NMDS observou-se diferenças na composição de espécies entre as áreas estudadas. Os resultados indicaram uma alta riqueza de plantas daninhas nativas e exóticas invasoras, as quais representam grande impacto econômico para os agricultores da região, assim como para os ecossistemas naturais.
Tailoring a symmetry for material properties of tellurite glasses through tungsten(vi) oxide addition: Mechanical properties and gamma-ray transmissions properties
Authors: ALMisned Ghada , Khattari Ziad Y. , Rabaa Elaf , Rammah Yasser S. , Sen Baykal Duygu , Kilic Gokhan , Zakaly Hesham M. H. , Ene Antoaneta , Tekin Huseyin Ozan
Published: May 2023

We report a correlation outcome for mechanical and gamma-ray transmission properties of tellurite glasses by increasing tungsten(vi) oxide concentration in glass structure. The mechanical properties as well as Poisson’s ratio (σ) of the studied glasses are estimated by applying Makishima–Mackenzie model. Gamma-ray attenuation properties using various fundamental parameters are determined in 0.015–15 MeV energy range. Poisson’s ratio (σ) decreased from 0.43017 to 0.42711, while all elastic moduli increased linearly with the molar increment of either [WO3] or [TeO2] in the molecular structure of the glass network. Moreover, gamma-ray attenuation properties are enhanced as a function of increasing WO3substitution amount from 30 to 50% mol in the glass structure. Half-value layer values at 15 MeV are found to be between 2.648 and 2.8614 cm. I4 samples with a composition of 20TeO2–50WO3–30GdF3and density of 6.0530 g/cm3was found to have superior material properties in terms of elastic and gamma-ray attenuation properties. It can be concluded that maximized WO3contribution into the tellurite glasses may be considered as a critical tool in terms of establishing a symmetry between mechanical and gamma-ray attenuation properties for high-density tellurite glasses for their potential utilization in nuclear waste management, radiation shielding, and radioactive source transportation purposes.
Difficult to think about but easy to treat: scurvy
Authors: Küçükçongar Yavaş Aynur , Engin Erdal Ayşenur , Çıtak Kurt Ayşegül Neşe , Kurt Tuba , Cankurt İlknur , Ünal Uzun Özlem
Published: May 2023

Objectives

Severe vitamin C deficiency, or scurvy, presents as a syndrome of multisystem abnormalities associated with defective collagen synthesis and antioxidative functions. The many clinical features of scurvy lead to frequent misdiagnoses, as they can often point to other diseases, such as vasculitis, venous thrombosis and musculoskeletal disorders. As such, an extensive workup is recommended in cases in which scurvy is suspected.

Case presentation

A 21-month-old male patient and a 36-month-old female patient presented with difficulty in walking, painful joint movements, irritability, gingival hypertrophy and bleeding. After exhaustive investigations and risky invasive procedures, vitamin C deficiency was diagnosed in both cases, and the symptoms improved dramatically with vitamin C treatment.

Conclusions

The importance of taking a dietary history in pediatric patients is highly recommended. In cases where scurvy is considered, serum ascorbic acid levels should be checked to confirm the diagnosis prior to conducting invasive tests.
Hebrew copulative perception verbs
Authors: Fishman Alon
Published: May 2023

Copulative perception verbs such as English sound have received scant attention relative to other perception verbs, especially in non-European languages. In Hebrew, these verbs can take both adjectival and adverbial complements, a fact which sets Hebrew apart from previously studied languages, and which has heretofore been overlooked. This article investigates the usage of Hebrew copulative perception verbs with adverbial complements, with adjectival complements, and in impersonal constructions. A large-scale corpus study and a preference experiment reveal that each of these three constructions has a different interpretation. With adverbial complements, the verbs have an “attributary” meaning, attributing properties to perceptual impressions of objects. The complement slot in these cases is restricted to subjective multidimensional properties, which previous accounts of the attributary meaning fail to predict, motivating a novel analysis in terms of dimension selection. With adjectival complements, as well as in impersonal constructions, the verbs have a parenthetical meaning, taking and modifying a proposition argument. The two constructions are not equivalent, however. With adjectival complements, the verbs encode evidential but not epistemic information, and vice versa in impersonal constructions, reinforcing the need to maintain a distinction between the classes of evidentials and epistemic modals.
The poor performance of cardiovascular risk scores in identifying patients with idiopathic inflammatory myopathies at high cardiovascular risk
Authors: Qin Li , Luo Qiang , Hu Yinlan , Yan Shuangshuang , Yang Xiaoqian , Zhang Yiwen , Xiong Feng , Wang Han
Published: May 2023

Framingham risk score (FRS), systematic coronary risk evaluation (SCORE), the 10-year atherosclerotic cardiovascular disease risk algorithm (ASCVD), and their modified risk scores are the most common cardiovascular risk scores. The aim of this case–control study was to evaluate the performance of cardiovascular risk scores in detecting carotid subclinical atherosclerosis (SCA) in patients with idiopathic inflammatory myopathies (IIMs). A total of 123 IIMs patients (71.5% female, mean age 50 ± 14 years) and 123 age- and gender-matched healthy controls were included in this study. Carotid SCA was more prevalent in IIMs patients compared with controls (77.2 vs 50.4%, P < 0.001). Moreover, patients with carotid SCA+ had older age, and all risk scores were significantly higher in IIMs patients with SCA+ compared to subjects with SCA− (all P < 0.001). According to FRS, SCORE, and ASCVD risk scores, 77.9, 96.8, and 66.7% patients with SCA+ were classified as low risk category, respectively. The modified scores also demonstrated a modest improvement in sensitivity. Notably, by adopting the optimal cutoff values, these risk scores had good discrimination on patients with SCA+, with area under curves of 0.802–0.893. In conclusion, all cardiovascular risk scores had a poor performance in identifying IIMs patients at high cardiovascular risk.
DNA origami-designed 3D phononic crystals
Authors: Park Sung Hun , Park Haedong , Nam Jwa-Min , Ke Yonggang , Liedl Tim , Tian Ye , Lee Seungwoo
Published: May 2023

Moulding the flow of phononic waves in three-dimensional (3D) space plays a critical role in controlling the sound and thermal properties of matter. To this end, 3D phononic crystals (PnCs) have been considered the gold standard because their complete phononic bandgap (PnBG) enables omnidirectional inhibition of phononic wave propagation. Nevertheless, achieving a complete PnBG in the high-frequency regime is still challenging, as attaining the correspondingly demanded mesoscale 3D crystals consisting of continuous frame networks with conventional fabrications is difficult. Here, we report that a DNA origami-designed-3D crystal can serve as a hypersonic 3D PnC exhibiting the widest complete PnBG. DNA origami crystallization can unprecedentedly provide 3D crystals such that continuous frame 3D crystals at the mesoscale are realizable. Furthermore, their lattice symmetry can be molecularly programmed to be at the highest level in a hierarchy of symmetry groups and numbers, which can facilitate the widening of the PnBG. More importantly, conformal silicification can render DNA origami-3D crystals rigid. Overall, we predict that the widest hypersonic PnBG can be achieved with DNA origami-designed 3D crystals with optimal lattice geometry and silica fraction; our work can provide a blueprint for the design and fabrication of mesoscale 3D PnCs with a champion PnBG.
Multifunctional charge transfer plasmon resonance sensors
Authors: Koya Alemayehu Nana , Li Wei
Published: May 2023

Charge transfer plasmon (CTP) modes arise when metallic nanoparticle dimers are connected by a conductive junction. This offers a unique opportunity to explore electron transport at optical frequencies as well as to attain narrow plasmon resonances that can be broadly modulated from visible to IR regimes, implying their potentials for applications in single-molecule electronics and sensing. This article showcases recent developments in theory and applications of charge transfer plasmon resonances (CTPRs) in various configurations of conductively linked plasmonic nanodimers. In particular, we give a due attention to exploiting ultratunable spectral features of charge transfer plasmon resonances for developing multifunctional plasmonic sensors for bulk, surface, gas and molecular sensing applications. We also discuss the implications of the charge and energy transfer between two plasmonic nanoparticles linked by sub-nanometer thick self-assembled monolayers for single-molecule conductance sensing and molecular electronics. In addition to the well-established plasmonic sensing schemes based on propagating and localized surface plasmon resonances, charge transfer plasmon resonance sensors may open up a new route in efforts to develop multifunctional sensing technologies.
The crystal structure of dimethyl 2,2ʹ-((adamantane-1,3-diylbis(4,1-phenylene)) bis(oxy))diacetate, C28H32O6
Authors: Chen Xiao-Ming , Zeng Fei
Published: May 2023

C28H32O6, orthorhombic, Pnma (no. 62), a = 7.752(2) Å, b = 29.959(8) Å, c = 10.176(3) Å, V = 2363.5(11) Å3, Z = 4, R
gt(F) = 0.1145, wR
ref(F
2) = 0.1076, T = 296(2) K.
Conservators’ Professional Visibility in Public Cultural Institutions in Jakarta: A Case Study
Authors: Sunarno Windri , Rachman Yeni Budi
Published: May 2023

This paper provides a discussion about the conservation profession in the Jakarta area of Indonesia. The study, which uses descriptive and qualitative research, was conducted among three public, cultural institutions: a museum, a conservation center, and a library. These institutions were chosen because of their collection of ancient manuscripts and their employment of professional conservators. The study’s findings show that conservators are concerned about the visibility of their profession in terms of lack of appreciation from the government as well as the status of their profession and that they believe they need professional associations and more comprehensive legal instruments to strengthen their profession’s visibility and the public’s opinion of them. This paper contributes to the discussion of the conservation profession, especially in the Indonesian context.
Hidden Players: Small Paper Nails—Manufacture and Application of Paper Nails in Chinese Double-Leaved Books
Authors: Yu Rong , Shen Zhewei , Liu Peng
Published: May 2023

Paper nails constitute a unique and important structure in Chinese double-leaved books. This technique may have existed as early as the Southern Song Dynasty (A.D.1127–1279) when wrapped-back bindings developed. Creating and applying paper nails is a basic skill for conservators in China. Although paper nails have always been used, there is not much literature discussing their manufacture and application. This article details the use of single and double-ended nails in China, including how to make, attach, and remove them, and provides illustrative examples of the role of paper nails in thread binding, rough binding, wrapped-back binding, and “Jade Set in Gold” (“jinxiangyu”, 金镶玉) binding. This work will be a reference for the conservation of Chinese double-leaved books and other documents.
Fabrication of monodisperse droplets and microcapsules using microfluidic chips: a review of methodologies and applications
Authors: Su Weiguang , Han Bing , Yeboah Siegfried , Du Dengfeng , Wang Li
Published: May 2023

Microfluidics has been applied in the preparation of monodisperse droplets and microcapsules due to its high encapsulation efficiency, its ability to create uniform particle sizes, and its capacity to control core–shell ratio and structure. To bring to the fore methodologies for the fabrication and application of monodisperse microcapsules using microfluidics, we present a review of the design, structure, materials, and surface modification techniques of various microfluidic chips. The review also covers fabrication methods, operating parameters and regulation methods of single and multiple monodisperse emulsion droplets fabricated from various microfluidic devices. Our findings show that particle size of monodisperse droplets depend mainly on microchannel characteristic size and flow rate, with particle size increasing with larger microchannel but decreasing with higher continuous phase flow rate. We additionally reviewed and compared various fabrication methods for monodisperse microcapsules, such as interfacial polymerization, free-radical polymerization, ionic cross-linking, and solvent evaporation. We further reviewed and examined the application of monodisperse microcapsules in biology applications, food engineering, composite materials development, and pharmaceutical industry. We found that high-throughput microfluidics for scale-up monodisperse microcapsule preparation towards uniform degradation and targeted release properties of monodisperse microcapsules would be key innovative direction for future applications.
Effects of man-made electromagnetic fields on heart rate variability parameters of general public: a systematic review and meta-analysis of experimental studies
Authors: Mansourian Mahsa , Marateb Hamidreza , Nouri Rasool , Mansourian Marjan
Published: May 2023

Objectives

The effects of man-made electromagnetic fields (EMFs) on the cardiovascular system have been investigated in many studies. In this regard, the cardiac autonomic nervous system (ANS) activity due to EMFs exposure, assessed by heart rate variability (HRV), was targeted in some studies. The studies investigating the relationship between EMFs and HRV have yielded conflicting results. We performed a systematic review and meta-analysis to assess the data’s consistency and identify the association between EMFs and HRV measures.

Content

Published literature from four electronic databases, including Web of Science, PubMed, Scopus, Embase, and Cochrane, were retrieved and screened. Initially, 1601 articles were retrieved. After the screening, 15 original studies were eligible to be included in the meta-analysis. The studies evaluated the association between EMFs and SDNN (standard deviation of NN intervals), SDANN (Standard deviation of the average NN intervals for each 5 min segment of a 24 h HRV recording), and PNN50 (percentage of successive RR intervals that differ by more than 50 ms).

There was a decrease in SDNN (ES=−0.227 [−0.389, −0.065], p=0.006), SDANN (ES=−0.526 [−1.001, −0.05], p=0.03) and PNN50 (ES=−0.287 [−0.549, −0.024]). However, there was no significant difference in LF (ES=0.061 (−0.267, 0.39), p=0.714) and HF (ES=−0.134 (0.581, 0.312), p=0.556). In addition, a significant difference was not observed in LF/HF (ES=0.079 (−0.191, 0.348), p=0.566).

Outlook

Our meta-analysis suggests that exposure to the environmental artificial EMFs could significantly correlate with SDNN, SDANN, and PNN50 indices. Therefore, lifestyle modification is essential in using the devices that emit EMs, such as cell phones, to decrease some signs and symptoms due to EMFs’ effect on HRV.
Synthetic data generation of vibration signals at different speed and load conditions of transmissions utilizing generative adversarial networks
Authors: König Timo , Wagner Fabian , Bäßler Robin , Kley Markus , Liebschner Marcus
Published: May 2023

Condition monitoring of machines and powertrain components is an essential part of ensuring reliability and product safety in many industries. The monitored machines and components are often divided into different condition classes as well as classified using machine learning methods. In order to enable classification with machine learning algorithms, the acquisition of a sufficient amount of data from each condition class is essential. In reality, the collection of data for faulty system states turns out to be much more difficult, therefore in many use cases balanced data sets are not available. However, when classifying faulty states, an identical number of data per class is of great importance. This problem can be counteracted with synthetic data generation. Generative Adversarial Networks (GAN) are a suitable approach to generate synthetic data based on real measured data. In most cases of synthetic data generation, different damage cases, e.g. from a transmission, are simulated, but a generation of synthetic data is not performed at different operating conditions. However, different speeds and torques are a reality when monitoring, as the drive systems operate under changing operating conditions. Therefore, in the context of this paper, synthetic data generation at different operating states is investigated in order to implement a condition monitoring system for good and bad system conditions which includes different operating states. So, vibration data is acquired at different operating conditions of a transmission on a drive test rig and relevant features are highlighted using a suitable signal pre-processing method. The features, caused by different operating conditions, can also be generated synthetically by GAN. Therefore, it is possible to achieve a similar classification accuracy by integrating synthetically generated data as with real data, which makes the synthetic data generation a viable solution for extending existing data sets.