bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploitation des contes dans lâ€™apprentissage des mathÃ©matiques au prÃ©scolaire
Authors: Nadifi Abdel Ilah , Hattaf Khalid , Karzazi Wafae
Published: March 2021

Dans cet article, nous nous intÃ©ressons Ã  lâ€™exploitation des contes dans lâ€™enseignement-apprentissage de certaines notions mathÃ©matiques au prÃ©scolaire. Pour ce faire, nous commenÃ§ons par la prÃ©sentation de lâ€™enseignement des mathÃ©matiques au prÃ©scolaire marocain. Les capacitÃ©s attendues dans cette phase dâ€™apprentissage sont aussi prÃ©sentÃ©es. Ensuite, nous proposons deux contes, lâ€™un pour introduire les trois aspects du nombre et lâ€™autre pour initier lâ€™enfant Ã  la triangulation de type Î”1 et Ã  la statistique. De plus, nous Ã©tudions lâ€™impact de ces deux contes sur le dÃ©veloppement psychomoteur de la petite enfance et lâ€™apprentissage des mathÃ©matiques au prÃ©scolaire. Cette Ã©tude montre comment les contes peuvent Ãªtre utilisÃ©s comme un excellent support didactique dans lâ€™introduction et lâ€™initiation de certaines notions mathÃ©matiques au prÃ©scolaire afin de faciliter et de donner sens Ã  lâ€™apprentissage et aussi d'amÃ©liorer les habiletÃ©s psychomotrices de lâ€™enfant dans un cadre ludique et agrÃ©able.
 
In this paper, we are interested in the use of tales in the teachinglearning of some mathematical concepts in preschool. To do this, we start with the presentation of mathematics education in Moroccan preschool. The expected skills in this learning phase are also presented. After, we propose two tales one to introduce the three aspects of the number and the other to initiate the child about the Î”1-type triangulation and statistics. Furthermore, we study the impact of these two tales on early childhood psychomotor development and mathematics learning in preschool. This study shows how tales can be used as excellent didactic support in the introduction and initiation of certain mathematical notions in preschool in order to facilitate and give meaning to learning as well as to improve the psychomotor skills of the child in a fun and pleasant setting.
Prediction of Student Performance Using Rough Set Theory And Backpropagation Neural Networks
Authors: Madeira Bruno Cristos , Tasci Tugrul , Celebi Numan
Published: March 2021

With the rise of web-based education systems and the increased use of information systems in education institutions, the amount of data recorded on student performance and behavior has increased exponentially. Thus, bringing about a large number of contributions to the field of educational research, which in itself contributed to the further evolution off the field in the last two decades alone, with terms such as Educational Data Mining (EDM), Learning Analytics, Data-driven Education, Teaching Analytics and others being added to the literature. In this paper, we evaluate the usefulness of a model using Rough Set Theory (RST) and Backpropagation Neural Network (BPNN) in effectively predicting the studentsâ€™ overall performance. The dataset used consists of 10 different attributes and one decision factor belonging to 53 students collected from a language course which administers in-person education with the aid of an online platform for assignments. RST was implemented in order to reduce the number of attributes used as input in the neural network and the BPNN made an accurate prediction using only 5 of the initial attributes. Thus outperforming a model based solely on BPNN used on the original dataset and reducing computational costs.
Les Facteurs AssociÃ©s Aux Calcifications Valvulaires Du CÅ“ur Et Ou Des Gros Troncs ArtÃ©riels Chez Les HÃ©modialysÃ©s
Authors: DiakitÃ© Fousseny , Sidy Seck Mohamed , Fary Ka El Hadji , Tall Ahmed , CissÃ© Mohamed Moustapha , Niang Abdou , Diouf Boucar , Moussa Kane , Momar Dioum , Kane Abdoul
Published: March 2021

Introduction: Le but de lâ€™Ã©tude Ã©tait de dÃ©terminer la prÃ©valence ainsi que les principaux facteurs de risque associÃ©s au dÃ©veloppement des calcifications valvulaires du cÅ“ur et/ou dâ€™au moins un gros tronc artÃ©riel chez les hÃ©modialysÃ©s. Patients et mÃ©thodes: Etaient inclus les patients qui avaient prÃ©sentÃ© Ã  lâ€™Ã©chodoppler cardiaque une calcification valvulaire du cÅ“ur et ou dâ€™au moins un gros tronc artÃ©riel. Les variables suivantes avaient Ã©tÃ© Ã©tudiÃ©es : Ã©pidÃ©miologiques, cliniques et paracliniques. RÃ©sultats: Sur 54 patients hÃ©modialysÃ©s, 51 avaient Ã©tÃ© explorÃ©s parmi lesquels 39 prÃ©sentaient des calcifications cardio-vasculaires. Les femmes Ã©taient les plus touchÃ©es 66.67 % avec un sex- ratio de Â½. Les calcifications valvulaires reprÃ©sentaient 64.1% et les calcifications vasculaires 76.9%. Les atteintes univalvulaires reprÃ©sentaient 68% suivies des atteintes bivalvulaires 24% et trivalvulaires 8%. Les calcifications des artÃ¨res fÃ©morales Ã©taient les plus frÃ©quemment rencontrÃ©es 63.3% suivies des artÃ¨res iliaques 53.3 %. Conclusion: Les calcifications cardiovasculaires sont frÃ©quentes chez les hÃ©modialysÃ©s. Les principaux facteurs de risque liÃ©s Ã  la survenue des calcifications Ã©taient : lâ€™hypocalcÃ©mie, lâ€™hypo et lâ€™hypercholestÃ©rolÃ©mie Ã  LDL, lâ€™hyper cholestÃ©rolÃ©mie totale et le taux sanguin de PTHi augmentÃ©. La correction de ces troubles pourrait prÃ©venir la survenue des calcifications.
 
Introduction: The purpose of the study was to determine the prevalence and key risk factors associated with the development of valve calcifications of the heart and/or at least one large arterial trunk in hemodialysis. Patients and methods: Patients who had presented with cardiac echodoppler a valve calcification of the heart and or at least one large arterial trunk were included. The following variables had been studied: epidemiological, clinical and paraclinical. Results: Of 54 hemodialysis patients, 51 were explored, 39 of whom had cardiovascular calcifications. Women were the most affected 66.67% with a sex ratio of Â½. Valvular calcifications represented 64.1% and vascular calcifications 76.9%. Univalvular involvement accounted for 68% followed by bivalvular involvement 24% and trivalvular involvement 8%. Calcifications of the femoral arteries were the most frequently encountered 63.3% followed by the iliac arteries 53.3%. Conclusion: Cardiovascular calcifications are common in hemodialysis patients. The main risk factors related to the onset of calcifications were: hypocalcemia, hypo and hyperlolesterolemia with LDL, hyper hyper cholesterolemia and increased blood PTHi levels. The correction of these disorders would be a way to prevent the occurrence of calcifications.
Efeitos da incidência do ICMS e IRPF na distribuição de renda na Paraíba
Authors: Damiane Cerqueira da Silva Laércio , Leite Duarte Francisco , Oliveira Bruno
Published: March 2021

O objetivo deste estudo é investigar o efeito final do Sistema Tributário Nacional na distribuição de renda e na pobreza no Estado da Paraíba, a partir de informações da Pesquisa de Orçamento Famíliar (POF) 2017/2018, sobre o consumo e renda das famílias. Verifica-se se o Imposto Sobre Operações Relativas à Circulação de Mercadorias e Sobre Prestações de Serviços de Transporte Interestadual e Intermunicipal e de Comunicação (ICMS) na Paraíba é regressivo, e se essa possível regressividade é compensada pelo Imposto sobre a Renda da Pessoa Física (IRPF). A metodologia parte da mensuração do consumo das famílias e da participação de faixas de renda no total dos rendimentos após suposição de um acréscimo na renda que permita a família sair de uma classe mais baixa para a subsequente, apurando-se a renda líquida após a dedução do ICMS e IRPF. Os resultados encontrados mostram que o ICMS é um imposto regressivo, e que essa regressividade é compensada pelo IRPF. Não obstante, o grau de progressividade é insuficiente para fins distributivos frente as diferenças de rendimentos entre a primeira e última classe de renda.
Visuospatial reasoning of eighth-grade students in solving geometry problems: A gender perspective
Authors: Nuriswaty Kartika Sulistiya , Pagiling Sadrack Luden , Nurhayati Nurhayati
Published: March 2021

[English]: Visuospatial reasoning is indispensable in solving mathematical problems, especially geometry. However, many students face difficulty in visuospatial reasoning. This qualitative study aims to describe eighth-grade students' visuospatial reasoning in solving geometry problems in terms of gender differences. One male and one female student with high mathematics ability were involved. A test and interview were utilized to collect data. The test was used to investigate students' visuospatial reasoning and the interview was administered to confirm students' reasoning. Students’ test and interview results were analyzed in three stages: data condensation, data presentation, and conclusion drawing and verification. This study found that both male and female students' visuospatial reasoning in solving the problems is at the synthesis level. However, at the synthesis level, when identifying the spatial relationships between objects, the male student expresses information from the overall view scheme, while the female student expresses part by part of the view scheme.

Keywords: Visuospatial reasoning, Geometry problems, Gender

[Bahasa]: Penalaran visuospasial sangat diperlukan dalam menyelesaikan masalah matematika terutama pada masalah geometri. Namun, banyak siswa yang mengalami kesulitan dalam melakukan penalaran visuospasial. Penelitian kualitatif ini bertujuan mendeskripsikan penalaran visuospasial siswa kelas VIII yang ditinjau dari perbedaan gender dalam menyelesaikan masalah geometri. Satu siswa laki-laki dan satu siswa perempuan dengan kemampuan matematika tinggi dipilih sebagai subjek. Tes dan wawancara digunakan untuk mengumpulkan data. Tes digunakan untuk menyelidiki penalaran visuospatial siswa dan wawancara bertujuan mengonfirmasi dan menggali lebih dalam penalaran siswa. Data hasil tes dan wawancara dianalisis dalam tiga tahap, yaitu reduksi data, penyajian data, dan penarikan dan verifikasi simpulan. Hasil penelitian menunjukkan bahwa penalaran visuospasial siswa laki-laki dan perempuan dalam menyelesaikan masalah geometri berada pada jenjang sintesis. Namun, terdapat perbedaan pada jenjang sintesis dalam mengidentifikasi keterkaitan spasial antar objek-objek. Siswa laki-laki mengutarakan informasi dari skema pandangan secara menyeluruh, sedangkan siswa perempuan mengutarakan bagian per bagian dari skema pandangan tersebut.

Kata kunci: Penalaran visuospasial, Masalah geometri, Gender
INSETICIDAS BOTÂNICOS NO CONTROLE DE FORMIGAS
Authors: Da Silva Jaqueline Pinheiro , De Souza Lilian Lemos , Neto Carlos de Melo e Silva , Barreira Sybelle
Published: March 2021

As formigas cortadeiras são insetos sociais que apresentam castas reprodutoras e não reprodutoras, vivendo em colônias permanentes. Elas causam grandes prejuízos para plantações desde hortas caseiras a plantios de reflorestamento. Para seu controle é necessário a utilização indiscriminada do controle químico nas o que acaba representando um grande questionamento sobre os impactos ambientais da utilização dos defensivos agrícolas e seu comportamento nos ecossistemas. Porém, existe a necessidade do controle dessas pragas. Dentre as novas perspectivas adotadas, os extratos botânicos são apresentados com grande potencial utilização. Algumas plantas presentes na natureza podem possuir características repelentes ou deterrentes ao inseto, devido à ação de metabólitos secundários. O controle alternativo de pragas como a utilização de plantas com caraterísticas inseticidas pode ser muito promissor. Algumas plantas da família Lamiaceae podem ser utilizadas para repelir insetos, como é o caso da hortelã-pimenta (Mentha piperita), que é de fácil germinação e brotação. Outra erva que pode ser utilizada no controle de insetos é a Arruda (Ruta graveolens). Em virtude deste grande potencial, neste sentido o presente estudo procurou avaliar a eficiência da hortelã-pimenta e do extrato de Arruda, de forma qualitativa e quantitativa, no controle de formigas cortadeiras em um experimento instalado no Cinturão Verde, na Escola de Agronomia da UFG. E apresentando resultados promissores, pois ambas as plantas de controle se mostraram eficientes no controle das formigas.
ABORDAGEM DA TEMÁTICA “IMPACTO DAS DROGAS NA SAÚDE BUCAL” EM SALAS DE ESPERA: EXPERIMENTAÇÕES POLÍTICO-PEDAGÓGICAS VIVENCIADAS POR ESTAGIÁRIOS
Authors: ALMEIDA LUIZ EDUARDO DE
Published: March 2021

Objetivo: analisar as significâncias político-pedagógicas de vivências experimentadas por estagiários de um curso de Odontologia em salas de espera. Metodologia: estudo qualitativo transversalmente estruturado sob estratégia narrativo-descritiva e moldado à técnica argumentativa. Resultados: o “Estágio de Clínica Integrada em Atenção Primária” foi didaticamente sistematizado em dois períodos, “Pré-intervenção” e “Intervenção”. Do primeiro, se desvendaram duas ações, a “Contextualização dos acadêmicos estagiários” e a “Estruturação, Ambientalização e Levantamento de necessidades do ambiente de trabalho”. Já o segundo foi guiado pela lógica pedagógica do instrumento “TPC” (Teorizar-Praticar-Criticar), onde todas as ações programadas seguiram a lógica ativa do planejamento estratégico, ou seja, contextualizadas às realidades do cenário de prática (salas de espera). Conclusão: das experimentações vivenciadas algumas inferências se destacaram: a efetividade do instrumento “TPC” no direcionamento dos acadêmicos estagiários no planejamento estratégico de atividades de educação em saúde; o reconhecimento dos ambientes de espera como território fértil para o desenvolvimento de ações de educação em saúde; a importância de se disseminar, em espaços científicos, os aprendizados advindos de experimentações práticas de estágios.
Analisis Total Volatile Base (TVB) dan Uji Organoleptik Nugget Ikan Dengan Penambahan Kitosan 2,5%
Authors:   Universitas Madako Tolitoli, Dalle Darmawati , Natsir Hasnah , Dali Seniwati
Published: March 2021

Penelitian ini bertujuan untuk mengetahui pengaruh penambahan kitosan 2,5% pada nugget ikan melalui analisis Total Volatile Base (TVB) dan uji organoleptik. Analisis TVB terdiri dari tahap ekstraksi, destilasi dan titrasi. Sedangkan uji organoleptik menggunakan beberapa parameter yaitu uji kenampakan, aroma, tekstur, dan cita rasa. Hasil yang diperoleh menunjukkan bahwa penambahan kitosan 2,5% dapat memberi daya tahan pada nugget ikan hingga jam ke-24 dengan nilai TVB 21,79 mg-N/100g pada penyimpana suhu 27 °C. Sedangkan penyimpanan pada suhu 5 °C dapat memberi daya tahan hingga jam ke-72 dengan nilai TVB 13,43 mg-N/100g. Hasil uji organoleptik menunjukkan nugget ikan masih sangat disukai. Oleh karena itu, nugget ikan yang melalui proses pengawetan dengan penambahan kitosan 2,5% masih memenuhi syarat untuk dikonsumsi.
Pembuatan dan Pengujian Pupuk Organik Cair dari Limbah Kulit Buah-buahan dengan Penambahan Bioaktivator EM4 dan Variasi Waktu Fermentasi
Authors:   Politeknik Negeri Bandung, Widyabudiningsih Dewi , Troskialina Lina , Fauziah Siti , Shalihatunnisa Shalihatunnisa , Riniati Riniati , Siti Djenar Nancy , Hulupi Mentik , Indrawati Lili , Fauzan Ahmad , Abdilah Fauzi
Published: March 2021

Produksi olahan pangan dari buah-buahan selalu menghasilkan limbah kulit dalam pengolahannya. Limbah tersebut hanya dibuang dan dibiarkan menumpuk begitu saja oleh mansyarakat. Apabila tidak ditangani secara cepat akan menghasilkan bau yang tidak sedap sehingga akan mencemari lingkungan. Salah satu alternatif yang dapat dilakukan yaitu dengan cara mengolah limbah tersebut menjadi pupuk organik cair dengan proses fermentasi. Penelitian ini dilakukan untuk mengetahui kandungan hara makro dan kualitas dari pupuk organik cair, mengetahui waktu fermentasi optimum, harga pokok produksi dan BEP dari proses pembuatan pupuk organik cair. Penelitian ini dilakukan dengan cara menambahkan EM4, ragi, dan air gula ke dalam reaktor yang berisi limbah kulit buah yaitu kulit pisang, mangga dan nanas. Proses fermentasi dilakukan selama 34 hari dan dilakukan pengambilan sampel pada hari ke-7, 14, 24 dan 34 untuk dianalisis kandungan hara makro yang terdiri dari C-Organik, P, dan K dengan metode spektrofotometri UV/VIS, SSA dan N dengan metode Kjeldahl. Pada penelitian ini dihasilkan pupuk organik cair yang terbaik yaitu campuran limbah kulit pisang, mangga dan nanas dengan waktu fermentasi 7-14 hari dan kandungan unsur C-Organik, N-total, K2O, dan P2O5 masing-masing sebesar 17,4; 6,05; 2,50 dan 0,15 %. Pupuk organik cair yang dihasilkan sudah memenuhi baku mutu dari Permentan Nomor 261 tahun 2019 kecuali kandungan P2O5, walaupun demikian pupuk organik cair yang diperoleh ini memiliki kualitas yang lebih baik dibanding beberapa pupuk yang sudah dijual secara komersial. Biaya pokok produksi dari pembuatan POC ini sebesar Rp 770.554 dengan Break Event Point (BEP) pada 10 liter.
Tautomerism of para-Aminobenzylidene-para-methoxyaniline
Authors: Aldabbagh Asmaa Baker
Published: March 2021

ABSTRACT: In the early seventies received wide attention when Patai [1] published his book tagged the chemistry of the azomethane group and the aforementioned group is very important in the fields of chemistry, life sciences, chemical and pharmaceutical industries and medicine. The chemistry of imines includes two main groups is Schiff bases and oximes. as well as   presence of double bonds in the imines facilitated the possibility of their presence in the form of two Geometrical Isomers. Curtin and Husser [2] are among the first to discover the presence of imines in two forms, syn and anti, and the inability to separate these two forms in the imines is attributed to the freedom to rotate around the double bonds between The carbon and nitrogen atoms, which reduce the occurrence of the polarization process in C=N and facilitate the rotation process [3]. Keywords: tautomerism, organic chemistry, azomethane group
PÉRDIDA DE PRESTIGIO DEL PERIODISMO EN ITALIA
Authors: Pira Francesco , Centorrino Marco
Published: March 2021

Este artículo quiere analizar las dificultades por las que está pasando, actualmente, el periodismo italiano. Adoptamos una perspectiva que podríamos definir como microsistémica. El reconocimiento social y el prestigio del periodismo nunca habían alcanzado niveles tan bajos, sin embargo hay momentos en los cuales, por lo menos algunos medios escritos y audiovisuales, vuelven a tener prestigio, autoridad, capacidades profesionales. Por lo tanto es posible, como demuestran estos casos virtuosos, otra forma de hacer periodismo, más relacionado con el periodismo de investigación y alejados de los intereses particulares, de las rutinas burocráticas e institucionales.  Tomaremos en consideración, de manera especial, dos casos, uno más local y otro más internacional. Todo esto desde una perspectiva sociológica, es decir, teniendo en cuenta los efectos del tratamiento mediático sobre el sistema social y sobre las organizaciones afectadas más directamente.
Transformación, fragmentación y continuidad del sistema de partidos de Castilla-La Mancha (2003-2015)
Authors: Ramírez Dueñas José María
Published: March 2021

La literatura académica española ha prestado poco interés por el sistema de partidos en Castilla-La Mancha, al contrario que los del resto de Comunidades Autónomas, especialmente de aquellas consideradas históricas. En el presente texto se pretende analizar la evolución del comportamiento electoral de los ciudadanos de la región para observar la transformación del sistema de partidos, desde la hegemonía electoral del PSOE (2003 y 2007) hasta la llegada de la alternancia política (2011) y la vuelta al poder de los socialistas (2015). En base a las encuestas poselectorales del Centro de Investigaciones Sociológicas (CIS) de las elecciones autonómicas, se ha trazado algunas de las explicaciones para entender los alineamientos partidistas de la región. Los resultados indican que el éxito del PSOE está relacionado tanto con una mayor abstención diferencial de los votantes del PP así como por su voto dual en las elecciones autonómicas debido a una buena valoración del candidato socialista. Este modelo se va debilitando hasta que en 2011 la gestión de la crisis económica acaba con el PSOE en la oposición. Además, la menor fragmentación electoral en la región en las elecciones de 2015 parece estar influido, más que por cuestiones ideológicas, por el rechazo de los liderazgos de los dos candidatos de los partidos sistémicos.
¿Es necesario regular la práctica de surf durante el verano?
Authors: Santos Diego , Moreno Carrillo José Miguel
Published: March 2021

El surf evoca un estilo de vida hedonista, errante y relajado. Unos valores que encajan perfectamente con la mentalidad millennial.

Desde una perspectiva turística, existen dos formas diferentes de consumir surf. Por un lado existen una serie de personas visitarán destinos principalmente por recorrer olas, es decir la presencia de olas es su motivación principal del viaje, mientras que existe otro colectivo, mucho mayor en números absolutos que quiere aprovechar su visita a la playa para practicar surf, es decir, es simplemente una actividad complementaria; una experiencia dentro del viaje.

Conocer las características de ambas tipologías es realmente útil para los organismos de promoción y gestión del turismo, principalmente para anticiparse a posibles problemas que puedan surgir en sus arenales y así poder garantizar una sostenibilidad económica y social en ellos antes de que los conflictos sean demasiado graves.
Reseña libro Sexual Citizens
Authors: Rosas Jiménez Carlos Alberto
Published: March 2021

Sexual Citizens es producto de una de las investigaciones más completas que existen hasta el momento sobre el abuso sexual en los campus de las universidades[1]. Tomando como punto de referencia la Universidad de Columbia de Nueva York, este estudio aporta abundante luz para esclarecer no solo la dinámica del proceso que conduce al abuso sexual, sino que lanza tres conceptos fundamentales para aproximarse a la prevención del abuso en los campus universitarios. Combinando la atención de los proyectos de vida sexual de los estudiantes con la promoción de la ciudadanía sexual y la transformación de las geografías sexuales se sugiere una ruta hacia un mundo donde el abuso sexual sea menos común. Sin embargo, como dicen los autores, este libro no ofrece una solución como tal al problema del abuso sexual, sino que presenta una nueva forma de pensar acerca de este problema, una forma que promueva un aumento en la variedad de estudios de intervención. El propósito del libro ha sido mirar cómo las instituciones y las estructuras sociales y no cómo las psyches individuales contribuyen al abuso sexual (p. 153).

 

[1] Las traducciones al español son hechas por el autor de la reseña.
¿Del movimiento orgánico al post-orgánico? Cultura del movimiento y cultura del consumo en la evolución de la agricultura orgánica en Italia
Authors: Spillare Stefano
Published: March 2021

Haciendo referencia al contexto italiano, este ensayo pretende investigar el movimiento en defensa de la agricultura orgánica, su evolución a lo largo del tiempo, su desarrollo y su entorno cultural. El objetivo es profundizar los cambios sociales y culturales que se están produciendo en la sociedad italiana, así como los que afectan a los ámbitos más específicos de la agricultura y de la alimentación.

El análisis se centra, en especial manera, en la evolución más reciente del sector que parece caracterizarse, entre otras cosas, por un giro “consumista” que se relaciona con la llamada “hipótesis de la convencionalización”, así como con el desarrollo de un movimiento que podríamos definir como “post-orgánico”.

A partir de la literatura consultada, se abordan ambas hipótesis, tratando de perfilar las posibles evoluciones del sector.

El análisis se concluye con algunas referencias a la economía solidaria y al consumo crítico: se trata, en síntesis, del contexto más prometedor para el desarrollo de un posible movimiento post-orgánico. Sin embargo, podemos decir que, por lo menos por el momento, estamos todavía en una fase embrionaria y que este movimiento se está perfilando más como una perspectiva analítica que como una identidad colectiva concreta.
EL AGUA COMO CLAVE DEL ECODESARROLLO URBANO: PAISAJE, PATRIMONIO, TERRITORIO Y SOCIEDAD
Authors: Zaragoza-Martí María Francisca
Published: March 2021

Actualmente, más del cincuenta por ciento de la población mundial vive en las urbes, configuradas éstas como lugar de reunión de una multiculturalidad moderna, innovadora y preocupada con su entorno, que no acepta seguir con el planeamiento urbanístico y de crecimiento de las últimas décadas. Surgen así los movimientos sociales actuales que claman por una nueva planificación urbana y paisajística donde se tengan en cuenta los recursos naturales, cambiando el clásico paradigma de la dominación por otro ecosostenible. En consecuencia, a través de una metodología eminentemente jurídica, se pretende exponer la necesaria relación entre el desarrollo paisajístico y el crecimiento urbano, a través del valor inmaterial que el agua posee en la creación de entornos sociales de calidad. A la vista de los resultados, queda patente el escaso valor de los espacios hidrológicos como configuradores del entorno y su nula inclusión como elementos de ordenación urbana y de calidad de vida en la ciudad.
La integración del inmigrante marroquí en el ámbito educativo: una propuesta desde la mediación cultural
Authors: HIRI Abdelhak
Published: March 2021

La incorporación de niños marroquíes a la escuela española, ha hecho posible que los centros educativos españoles se conviertan en arco iris cultural y lingüístico. Sin embargo, la presencia de esa diversidad con diferentes concepciones de la educación y con dificultades de comunicación fruto de la diversidad lingüística y cultural puede condicionar, en ocasiones, el entendimiento mutuo.  La necesidad de dar respuesta a esta realidad, nos ha inducido a enfatizar sobre la mediación cultural en los centros educativos, como respuesta a una educación que anda a la búsqueda de nuevas formas de enseñar y nuevos espacios de aprender, nuevas formas de convivir bajo la visión de la interculturalidad. Dicho de otro modo, resulta interesante para la integración del inmigrante marroquí, ya que, aunque hay otras experiencias en este sentido, no había un suficiente referente exclusivo para el colectivo marroquí en el ámbito educativo, por lo que esperamos que nuestro trabajo sirva para avanzar en la reflexión de la integración educativa del inmigrante marroquí.
Trends in burden of multidrug-resistant tuberculosis in countries, regions, and worldwide from 1990 to 2017: results from the Global Burden of Disease Study
Authors: Ou Zejin , Yu Danfeng , Liang Yuanhao , He Wenqiao , Li Yongzhi , Meng Yaxian , Xiong Husheng , Zhang Minyi , He Huan , Gao Yuhan , Wu Fei , Chen Qing
Published: March 2021

Background This study aimed to estimate the trends of multidrug-resistant tuberculosis (MDR-TB), which can be used to inform health strategies.Methods Data were collected from the Global Burden of Disease Study 2017. The estimated annual percentage change (EAPCs) were calculated to assess the trends of MDR-TB burden from 1990 to 2017.Results Globally, the ASR of MDR-TB burden including incidence, prevalence, death and disability-adjusted life years (DALYs) had pronounced increasing trends from 1990 to 1999, with the EAPCs were 17.63(95% confidence interval [CI]: 10.77 to 24.92), 17.57(95%CI: 11.51 to 23.95), 21.21(95%CI:15.96 to 26.69), and 21.90(95%CI: 16.55 to 27.50), respectively. Particularly, the largest increasing trends were seen in areas and countries of low and low-middle sociodemographic index (SDI). However, the trends in incidence, prevalence, death and DALYs of MDR-TB decreased globally from 2000 to 2017, with the respective EAPCs were −1.37(95%CI: −1.62 to −1.12), −1.32(95%CI: −1.38 to −1.26), −3.30(95%CI: −3.56 to −3.04) and −3.32(95%CI: −3.59 to −3.06). Decreasing trends of MDR-TB were observed in most regions and countries, particularly that of death and DALYs in Slovenia were −18.96(95%CI: −20.82 to −17.06) and −19.35 (95%CI: −21.10 to −17.55), respectively. Whereas the pronounced increasing trends of MDR-TB occurred in Papua New Guinea, Singapore, and Australia.Conclusions the ASR of incidence, prevalence, death and DALYs of MDR-TB showed decreasing trends from 2000 to 2017. However, the MDR-TB burden remains a substantial challenge to the TB control globally, and requires effective control strategies and healthcare.
Online Art Therapy in Elementary Schools During COVID-19: Results from A Randomized Cluster Trial and Impact on Mental Health.
Authors: Malboeuf-Hurtubise Catherine , Léger-Goodes Terra , Mageau Geneviève A. , Taylor Geneviève , Herba Catherine , Chadi Nicholas , Lefrançois David
Published: March 2021

Background: Emerging literature on the current COVID-19 crisis suggests that children may experience increased anxiety and depression as a result of the pandemic. To prevent such school and mental health-related problems, there is a timely need to develop preventive strategies and interventions to address potential negative impacts of COVID-19 on children’s mental health, especially in school settings. Results from previous child clinical research indicate that art-based therapies, including mindfulness-based art therapy, have shown promise increase children’s well-being and reduce psychological distress. Objective: The goal of the present pilot and feasibility study was to compare the impact of an emotion-based directed drawing intervention (experimental condition) and a mandala drawing intervention (active control condition), both group-based, delivered online and remotely, on mental health, in elementary school children (N=30), in the context of the COVID-19 pandemic. A randomized cluster trial was implemented to evaluate and compare the impact of both interventions on anxiety, depression, inattention and hyperactivity symptoms. Results: ANCOVAs revealed a significant effect of the type of drawing intervention on levels of inattention, after controlling for baseline levels. Participants in the emotion-based directed drawing group showed lower inattention scores at post-test, when compared to participants in the mandala group. Conclusion: Overall, results from this pilot and feasibility study showed that an emotion-based directed drawing intervention was more beneficial than a mandala drawing intervention on inattention symptoms of elementary school children, in the context of the current COVID-19 pandemic. From a feasibility standpoint, results indicate that the implementation of both interventions online and remotely, through a videoconference platform, is feasible and adequate in school-based settings. Further work incorporating larger sample sizes, longitudinal data and ensuring sufficient statistical power is warranted to evaluate the long-term impact of both interventions on children’s mental health.
EMBRYONAL TUMORS OF THE CENTRAL NERVOUS SYSTEM IN ADULTS: A REPORT OF THREE CASES. REVIEW OF THE LITERATURE
Authors: Matsko M. V. , Matsko D. E. , Imyanitov E. N. , Sklyar S. S. , Ulitin A. Yu. , Yakovenko I. V. , Ievleva A. G. , Ershov G. A. , Romanko A. A. , Nechaeva A. S.
Published: March 2021

Background. Еmbryonal tumors of the central nervous system are malignant neoplasms that mainly occur in pediatric patients with a peak incidence at the age of 4 years. These tumors usually have small round blue cell histology and low differentiation.

Method and case description. A report of three cases with embryonal CNS tumors of supratentorial localization has been presented. Immunohistochemical analysis classified these tumors as neuroblastoma (2 cases: Syn (+), NSE (+), CD (+) and Ki67 10/40 %; ages were 33 and 52 years) or ganglioneuroblastoma (1 case: Syn (+), NSE (+), CD 99 (+) and Ki67 40 %; age was 37 year). All patients underwent RT in a total dose of 60 Gy delivered to the area of the removed tumor and 6 cycles of adjuvant chemotherapy: patients with neuroblastoma received chemotherapy using EP regimen (cisplatin + etoposide), and patient with ganglioneuroblastoma received temozolomide.

Results. An objective response to therapy was achieved in all 3 patients. The relapse-free survival (RFS) in the first case of neuroblastoma was 51 months, the overall survival (OS ) was more than 105 months (8 years 9 months); in the second case of neuroblastoma, RFS was 25 months 2 weeks and OS was more than 26 months. Both neuroblastomas contained ID H1(R132H) mutation. In the patient with ganglioneuroblastoma, the RFS was 87 months, and the OS was over 93 months (7 years, 9 months, 3 weeks).

Conclusion.Supratentorial embryonal tumors of the central nervous system in adults are exceptionally rare and have a relatively favorable response to the standard treatment.
DRUG THERAPY FOR ANDROGEN-POSITIVE BREAST CANCER
Authors: Zikiryakhodjhaev A. D. , Fedenko A. A. , Starkova M. V. , Surkova V. S. , Sedova M. V.
Published: March 2021

There are some types of breast cancer (BC) that depend on their molecular characteristics. However, lately researchers provide date regarding the presence of additional receptors of triple negative breast cancer (TNBC). One of them is LA R-subtype that has androgen receptors (AR) on breast cancer cells. The role of AR in the development of this pathology is still controversial. According to some authors, stimulation of AR leads to the proliferation suppression, in the opinion of others – to the activation and potentiation of tumor invasion. There is also a version of the dichotomous effect of androgens that depends on the concentration of this hormone. The various effects of LA R-subtype therapy of BC are also explained by the presence of many other regulator proteins that interact with AR. The first attempts to treat BC with androgen have begun since the 40s of the last century, but in those years it did not have the desired effect and was not used until recently. Currently, the basic mechanisms of the effect of androgens on BC cells on the molecular level are known, and researches try to use androgen therapy, also in combination with aromatase inhibitors to increase the concentration of endogenous testosterone. The effects of selective androgen receptor modulators and anabolic steroids are being studied. However, in the last decade, the largest number of studies focused on the study of anti-androgen therapy. Patients receive AR antagonists, such as enzalutamide, bicalutamide, that are prescribed for prostate cancer. Enzalutamide blocks both androgen- and estrogen-mediated tumor growth, and therefore can be used regardless of the presence of estrogen receptors (ER), in contrast to bicalutamide. The results showed a significant increase in disease free survival up to 16.5 months in patients with hormone positive BC.
GENDER SPECIFICITY OF COLORECTAL CANCER IN THE REPUBLIC OF TATARSTAN
Authors: Gataullin B. I. , Khasanov R. Sh. , Savelyev A. A. , Gataullin I. G.
Published: March 2021

The purpose of the study: to develop an expert system based on the construction of a «decision tree» for predicting the 5-year survival rate of patients with colorectal cancer.

Material and Methods. T he study included 654 patients with colorectal cancer (CRC) who were treated from 2013 to 2015, including 434 men and 220 women. The average age of patients was 64,1 ± 10,2 years. All patients underwent genetic analysis for the presence of a mutation in the K-ras gene from the primary tumor.

Results. For the Republic of Tatarstan, there are regional features of mutation of the K-ras gene: the frequency of mutations in tumors in men was less frequent (20.3 %) than in women (37.7 %), in patients of Slavic nationality, mutations were slightly more frequent – 39 % than in Tatars – 21 %. The gender approach to assessing long-term treatment results showed that in men with colorectal cancer, the most favorable treatment results were observed in patients with tumors in stage T1–2N0M0, regardless of the differentiation of the tumor and its mutational status. Low-grade tumors with any T should be considered prognostically unfavorable in men, with the presence of regional metastases and mutation of the K-ras gene, even in the absence of distant metastases: no patient lived 5 years. Based on the construction of a «decision tree», the most favorable treatment results were observed in female patients with tumors in stage T1–2–3N0M0 at the age of 70 years (5-year survival rate of 90 %), with tumors T1–2N0M0 at the age of 70 years (5-year survival rate of 81.8 %), regardless of the tumor differentiation and its mutational status. Tumors of any differentiation are prognostically unfavorable for women of the T3–4N0 stage with the presence of distant metastases (6 % of patients lived 5 years) and lowdifferentiated stage T4N0M0 tumors (5-year survival rate of 8 %).

Conclusion. G ender- and age-associated features of the development and course of CRC are relevant for oncologists to choose effective diagnostic and therapeutic measures.
COMBINATION OF LENVATINIB AND PEMBROLISUMAB IN THE TREATMENT OF ADVANCED ENDOMETRIAL CANCER: A CASE REPORT
Authors: Churuksaeva O. N. , Kolomiets L. A. , Villert A. B.
Published: March 2021

Background. Endometrial cancer is the most common malignancy of the female reproductive system. Patients with metastatic endometrial cancer have the overall 5-year survival rate of less than 20 %. The efficacy of treatment of advanced endometrial cancer remains low; therefore, the search for novel approaches for treating endometrial cancer is of great importance.

Case description. We report a case of a 68-year-old female who presented with advanced endometrial cancer with metastatic lesions found in the axillary and lumbar lymph nodes, liver and lungs. The disease progressed after third-line chemotherapy, with no deficiency in the DNA repair system. The patient was successfully treated with lenvatinib and pembrolisumab. The treatment was characterized by controlled minimal toxicity and a satisfactory quality of life. At 5 months, the patient is alive with stable disease.

Conclusion. Despite the progress in treating endometrial cancer including chemotherapy and hormone therapy, the prognosis of patients with metastatic endometrial cancer is poor. The discovery of new molecular markers (MSI , PD -L1) made it possible to develop a clinical approach using a combination of pembrolizumab and lenvatinib for patients with no deficiency in the repair system, for whom, the standard chemotherapy is ineffective. The presented case gives hope for the treatment of this category of patients.
SAFETY AND EFFICACY OF THORACOSCOPIC LOBECTOMY IN PATIENTS WITH STAGE I NON-SMALL CELL LUNG CANCER
Authors: Ryabov A. B. , Pikin O. V. , Bagrov V. A. , Kolbanov K. I. , Glushko V. A. , Vursol D. A. , Amiraliev A. M. , Barmin V. V. , Aleksandrov O. A.
Published: March 2021

Aim: to analyze short-and long-term treatment outcomes of thoracoscopic lobectomy in patients with stageI NSCLC .

Material and Methods. A total of 479 NSCLC patients with clinical stage I NSCLC were treated at the Department of Thoracic Surgery of Hertzen Research Cancer Center from 2010 to 2019.

Results. Conversion to thoracotomy was required in 62 (12.9 %) of patients. Postoperative complications occurred in 19.9 % of patients in the thoracoscopic group and in 25.8 % of patients in the conversion group: the mortality rates were 0.4 % and 1.6 % respectively. The most common complication was prolonged air-leak (>5 days), which was diagnosed in 11.9 % and 8.0 % of patients respectively. In patients aged >70 years, the rate of complications was 35.8 % in the thoracoscopic group and 41.2 % in the conversion group. Thoracoscopic lobectomy had advantages over thoracotomy in terms of less postoperative pain syndrome and much less decrease in FEV1 during the first postoperative days and months. In patients with pT1-2aN0M0, stage I NSCLC , the overall and disease-free 5-year survival rates were respectively 92.2 % and 86.6 % after thoracoscopic lobectomy and 87.5 % и 81.2 % after conversion.

Conclusion. Thoracoscopic lobectomy is relatively safe procedure for patients with stage I NSCLC . To perform this type of surgery safely, the surgeon should pass the learning curve. Long-term outcomes were similar between patients undergoing thoracoscopic lobectomy and patients undergoing thoracotomy.
THE PROGNOSTIC SIGNIFICANCE OF MYXOID MATRIX IN RETROPERITONEAL WELL-DIFFERENTIATED LIPOSARCOMA
Authors: Volkov A. Yu. , Kozlov N. A. , Nered S. N. , Stilidi I. S. , Stroganova A. M. , Arkhiri P. P. , Antonova E. Yu. , Privezentsev S. A.
Published: March 2021

Objective: to assess the influence of the myxoid matrix in retroperitoneal well-differentiated liposarcoma(WDLPS ) on the long-term results of surgical treatment of patients.

Material and Methods. The study included 111 patients with primary retroperitoneal WDLPS who underwent radical surgical treatment in Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation. Histological slides of all surgical specimens were reviewed by experienced pathologist and reclassified according to criteria of WHO (2013) for histological subtypes of the WDLPS . Patients were divided into groups depending on presence or absence of the myxoid matrix in WDLPS and enrolled in intergroup analysis of overall (OS ) and recurrence-free (RFS) survival.

Results. OS was significantly worse in the group of patients with the myxoid matrix in the tumor (p=0.002; log-rank test). The median OS was 142 (95 % CI , 108, 176) months in the group without the myxoid matrix, and 84 (95 % CI , 29, 139) months in the group with the myxoid matrix. The 5-year survival rates were 79 % and 44 % in the groups without myxoid matrix and with myxoid matrix, respectively. RFS was also significantly worse in the group of patients with the myxoid matrix than in the group of patients without the myxoid matrix (p=0.006; log-rank test). The median RFS was 55 (95 % CI , 38, 72) months in the WDLPS group without the myxoid matrix, and 31 (95 % CI , 15, 47) months in the WDLPS group with the myxoid matrix. The 2-year RFS rates were 75 % and 44 % in the groups without the myxoid matrix and with the myxoid matrix, respectively.

Conclusion. The results of the study demonstrated that the presence of the myxoid matrix in WDLPS was associated with poor prognosis. We believe that the presence of the myxoid matrix in WDLPS can serve as an effective morphological marker of a less favorable prognosis for retroperitoneal WLPS .
EPIDEMIOLOGY AND CLINICO-DEMOGRAPHIC CHARACTERISTICS OF DLBCL IN THE NOVOSIBIRSK CITY
Authors: Voropaeva E. N. , Gurageva A. A. , Pospelova T. I. , Kolesnikova M. A. , Voevoda M. I. , Maksimov V. N. , Berezina O. V. , Khalzov K. V. , Churkina M. I. , Nechunaeva I. N. , Melnichenko E. V.
Published: March 2021

Background. The annual reporting forms for malignant neoplasms do not provide for the division of lymphomas into variants. In international publications and statistical reference books of the Russian Federation, variants of non-Hodgkin’s lymphomas (NHL) are also not separated. For these reasons, a detailed assessment of the epidemiology of NHL in Russia is difficult, and data for individual variants of the disease are not provided.

Purpose: to present the clinical and epidemiological characteristics of Diffuse Large B-cell Lymphoma (DL BCL ) in Novosibirsk according to the data of the City Hematology Center (CHC).

Material and Methods. A retrospective analysis of primary medical documentation (case histories,  outpatient charts, and immunohistochemical study reports) of 271 patients with DL BCL was performed in the period from January 1, 2013 to December 31, 2018.

Results. The calculated registered primary morbidity and mortality from DL BCL in Novosibirsk for the analyzed years fluctuated slightly. The average incidence and mortality rates were 2.85 and 1.98 per 100,000 population, respectively. When analyzing the dynamics of the prevalence of DL BCL in Novosibirsk, a positive trend of annual increase in the indicator was revealed: 1.87 times over the past 6 years. In men, the tumor developed 2.6 years earlier than in women. In General, the risk of getting DL BCL after 50 years was 3 times higher than at the age of 30 years. Among patients diagnosed with primary lymphoma who underwent treatment at the Hematology department of CHC, half of the patients had DL BCL .Evaluation of the clinical characteristics showed a pronounced severity of the analyzed cohort.

Conclusion. The updated quantitative and qualitative indicators of clinical and epidemiological characteristics of DL BCL in Novosibirsk for 2013–18 were obtained. These indicators can be used for further monitoring, development and implementation of measures for the prevention, diagnosis and treatment of this form of hemoblastosis.
RELATIONSHIP BETWEEN THE BLOOD LEVELS OF INFLAMMATORY CYTOKINES AND THE NUMBER OF CIRCULATING TUMOR CELLS WITH RESPONSE TO STANDARD CHEMOTHERAPY IN PATIENTS WITH OVARIAN CANCER
Authors: Gening S. O. , Rizvanov A. A. , Abakumova T. V. , Dolgova D. R. , Gafurbaeva D. U. , Rakhmatullina A. R. , Antoneeva I. I. , Gening T. P.
Published: March 2021

Introduction. Serum chemokines are inflammatory mediators, which role is shown in the occurrence and progression of a number of malignant tumors. Produced by white blood cells, stem cells, tumor and endothelial cells, chemokines control their movement and positioning. Chronic inflammation underlies the progression of ovarian cancer (OC ). This increases the likelihood of chemokines stimulating or blocking tumor progression.

The aim of the study was to evaluate the relationship between the blood levels of inflammatory cytokines in blood and the number of circulating tumor cells (CTC s) with the response to standard chemotherapy (CT ) in patients with cancer.

Material and Methods. In patients with primary OC before and after 2–4 courses of chemotherapy and in patients with benign ovarian tumors (as a control), serum levels of CCL 2, CCL 3, CCL 4, CXCL 8 and CX3CL 1 were evaluated by multiplex xMAP analysis. The amount of CTC s (population CD 45-/ Epcam+/CK+) was determined using a flow cytometer. Patients with ovarian cancer were divided into 3 groups according to the platinum sensitivity criterion of GC JG 4th, and progression-free interval (PFI) was determined.

Results. It was found that the levels of CCL 2, CCL 3, CCL 4, CXCL 8, and CX3CL 1 in case of OC did not significantly differ from that in the control, strongly negatively correlated with age (except for the CCL 2 level). CT significantly increased the level of CCL 2 in the group of refractory OC ; of CCL 3 – in the group of sensitive OC , of CCL 4 – in the groups of resistant and sensitive OC , and C XCL 8 level increased in the groups with resistant and sensitive OC and decreased in the group of refractory OC . The number of CTC s in patients with OC was significantly higher than in the control. After CT , a decrease in the amount of CTC s strongly and significantly correlated with a decrease in the level of CX3CL 1 in the groups of refractory andsensitive OC . The maximum PFI occurred with an increase in serum levels of CCL 3, CXCL 8, a decrease in CCL 4 and a constant level of CX3CL 1.

Conclusion. Thus, no significant differences in the levels of CCL 2, CCL 3, CCL 4, and IL -8 between patients with OC and control groups were found. The levels of chemokines studied and the amount of CTC s differed in the groups divided by the tumor sensitivity to CT . We observed significant correlations between the amount of CTC s and the level of CX3CL 1 in the group of platinumsensitive OC .