bluuebunny/crossref_metadata_2025 huggingface dataset:
Stacking Multiple Genes Improves Resistance to Chilo suppressalis, Magnaporthe oryzae, and Nilaparvata lugens in Transgenic Rice
Authors: Li Bai , Chen Zhongkai , Chen Huizhen , Wang Chunlei , Song Liyan , Sun Yue , Cai Yicong , Zhou Dahu , Ouyang Linjuan , Zhu Changlan , He Haohua , Peng Xiaosong
Published: May 2023

The ability of various pests and diseases to adapt to a single plant resistance gene over time leads to loss of resistance in transgenic rice. Therefore, introduction of different pest and disease resistance genes is critical for successful cultivation of transgenic rice strains with broad-spectrum resistance to multiple pathogens. Here, we produced resistance rice lines with multiple, stacked resistance genes by stacking breeding and comprehensively evaluated their resistance to Chilo suppressalis (striped rice stemborer), Magnaporthe oryzae (rice blast), and Nilaparvata lugens (brown planthopper) in a pesticide-free environment. CRY1C and CRY2A are exogenous genes from Bacillus thuringiensis. Pib, Pikm, and Bph29 are natural genes in rice. CH121TJH was introduced into CRY 1C, Pib, Pikm, and Bph29. CH891TJH and R205XTJH were introduced into CRY 2A, Pib, Pikm, and Bph29. Compared with those observed in their recurrent parents, CH121TJH significantly increased the mortality of borers. The other two lines CH891TJH and R205XTJH are the same result. Three lines introduction of Pib and Pikm significantly reduced the area of rice blast lesions, and introduction of Bph29 significantly reduced seedling mortality from N. lugens. Introduction of the exogenous genes had relatively few effects on agronomic and yield traits of the original parents. These findings suggest that stacking of rice resistance genes through molecular marker-assisted backcross breeding can confer broad spectrum and multiple resistance in differently genetic backgrounds.
Analysis of the Effects of IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C Gene Polymorphisms; IL-6 Levels; and CRP Levels on Chronic Periodontitis in Coronary Artery Disease in Indonesia
Authors: Sitompul Sanggap Indra , Pikir Budi Susetyo , Aryati  , Kencono Wungu Citrawati Dyah , Supandi Shafira Kurnia , Sinta Monika Estherlita
Published: May 2023

Interleukin 6 (IL-6) and C-Reactive Protein (CRP) play an important role in chronic periodontitis with coronary artery disease (CAD). Genetic factors can affect a person’s risk of CAD, which affects one-third of the population. This study investigated the role of IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C gene polymorphisms. IL-6 and CRP levels on the severity of periodontitis in CAD in Indonesia were also evaluated. This case-control study was conducted with mild and moderate–severe chronic periodontitis groups. A path analysis test was conducted with Smart PLS with a 95% confidence interval to determine the significant variable for chronic periodontitis. Our study revealed that the effects of IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C gene polymorphisms on IL-6 levels and CRP levels were not significant. IL-6 and CRP levels were not significantly different between the two groups. We found that IL-6 levels had a significant effect on CRP levels in periodontitis patients with CAD (path coefficient 0.322, p = 0.003). IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C gene polymorphisms had no effect on the severity of chronic periodontitis in CAD patients in the Indonesian population. We also observed no apparent effects of the influence of gene polymorphisms in IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C genes. Although the IL-6 and CRP levels were not significantly different between the two groups, IL-6 levels affected CRP levels in periodontitis patients with CAD.
Investigation of Real-Time Diagnostic Ultrasound as a Means of Biofeedback Training in Transversus Abdominus Re-Education of Patients with Non-Specific Low Back Pain: A Prospective Randomized Controlled Pilot Study
Authors: Taxiarchopoulos Nikolaos , Drakonaki Elena , Gianniotis Maria , Matzaroglou Charalampos , Tsepis Elias , Billis Evdokia
Published: May 2023

Background: It is believed that ultrasound-guided imaging of activation/contraction of the deep abdominal muscles (such as transervsus abdominis) is useful for assisting deep muscle re-education, which is often dysfunctional in non-specific low back pain (NSLBP). Thus, this pilot study aimed to evaluate the use of real-time ultrasound (US) as a feedback device for transverse abdominis (TrA) activation/contraction during an exercise program in chronic NSLBP patients. Methods: Twenty-three chronic NSLBP patients were recruited and randomly assigned to a US-guided (n = 12, 8 women, 47.6 ± 2.55 years) or control group (n = 11, 9 women, 46.9 ± 4.29 years). The same motor control-based exercise program was applied to both groups. All patients received physiotherapy twice per week for seven weeks. Outcome measures, tested at baseline and post-intervention, included Numeric Pain Rating Scale, TrA activation level (measured through a pressure biofeedback unit-based developed protocol), seven established motor control tests, Roland-Morris Disability Questionnaire and Hospital Anxiety and Depression Scale. Results: For each group, all outcome variables yielded statistical differences post-intervention (p < 0.05), indicating significant improvements. However, there were no significant group x time interactions for any of the outcomes (p > 0.05), thus, indicating no superiority of the US-guided group over the control. Conclusions: The addition of US as a visual feedback device for TrA re-education during a motor control exercise program was not proven superior to traditional physiotherapy.
A Retrospective Study of Epidemiological Correlations of Food, Drug and Chemical Poisoning in Al-Baha, Western Saudi Arabia
Authors: Beigh Saba , Mahzari Ali , Alharbi Read A. , Al-Ghamdi Rahaf A. , Alyahyawi Hanan E. , Al-Zahrani Hind A. , Al-Jadani Saeedah
Published: May 2023

Poisoning is a common and severe problem worldwide. Due to significant growth in the agricultural, chemical, and pharmaceutical industries over the past few decades, poisoning risks have increased with the use of food, chemicals, and medicines everywhere in the world, especially in Saudi Arabia. Advanced information on acute poisoning patterns is critical for the effective management of poisoning events. This study aimed to examine the characteristics of patients with various patterns of acute poisoning, caused by food, drugs, and chemicals, that were reported to the Department of Toxicology and Poison Center at King Fahad Hospital and the Poison Center in Al-Baha Province, Saudi Arabia. The study also examined the relationship between demographic characteristics, including age, toxin type, and geographical distribution, and poisonings in Baha Province. This retrospective cross-sectional analysis included 622 poisoning cases. The data were collected from 2019 to 2022 and it was found that out of 622 instances, 159 had food poisoning, with more men than females sick (53.5% male and 46.5% female), 377 had drug poisoning (54.1% males and 45.9% females), and 86 had chemical poisoning (74.4% males and 25.6% females). This study found that the most prevalent agents implicated in acute poisoning were medicines, particularly analgesics and antipsychotic drugs. Food poisoning was the second most common acute poisoning, affecting largely males followed by female patients. Finally, chemical poisoning involved acute poisoning, with most cases involving methanol and household items including the strongest bleaches (chlorines) (Clorox®, Oakland, CA, USA). Insecticides and pesticides were also secondary sources of chemical poisoning. Additional research revealed that the incidence of food, chemical, and drug poisoning was highest in children aged 1–15 years (food poisoning, n = 105, 66%; drug poisoning, n = 120, 31.8%); patients aged 11–20 years had the highest incidence of chemical poisoning (n = 41, 47.7%). Most poisoning incidents among youngsters are caused by easy access to drugs at home. Implementing strategies to enhance public awareness and limit children’s access to drugs would contribute considerably to decreasing the community’s burden of this problem. The findings of this study suggest that Al-Baha should improve its education regarding the rational and safe use of drugs and chemicals.
Analysis of Medico-Legal Complaint Data: A Retrospective Study of Three Large Italian University Hospitals
Authors: Di Fazio Nicola , Scopetti Matteo , Delogu Giuseppe , La Russa Raffaele , Foti Federica , Grassi Vincenzo M. , Vetrugno Giuseppe , De Micco Francesco , De Benedictis Anna , Tambone Vittoradolfo , Rinaldi Raffaella , Frati Paola , Fineschi Vittorio
Published: May 2023

(1) Background: Identifying hospital-related critical, and excellent, areas represents the main goal of this paper, in both a national and local setting. Information was collected and organized for an internal company’s reports, regarding civil litigation that has been affecting the hospital, to relate the obtained results with the phenomenon of medical malpractice on a national scale. This is for the development of targeted improvement strategies, and for investing available resources in a proficient way. (2) Methods: In the present study, data from claims management in Umberto I General Hospital, Agostino Gemelli University Hospital Foundation and Campus Bio-Medico University Hospital Foundation, from 2013 to 2020 were collected. A total of 2098 files were examined, and a set of 13 outcome indicators in the assessment of “quality of care” was proposed. (3) Results: From the total number, only 779 records (37.1%) were attributable to the categories indexable for the present analysis. This data highlights how, following a correct and rigorous categorization of hospital events, it is possible to analyze these medico-legal aspects using a small number of indicators. Furthermore, it is important to consider how a consistent percentage of remaining events was difficult to index, and was also of poor scientific interest. (4) Conclusions: The proposed indicators do not require standards to be compared to, but provide a useful instrument for comparative purposes. In fact, in addition to comparative assessment between different business realities distributed throughout the territory, the use of outcome indicators allows for a longitudinal analysis evaluating the performance of an individual structure over time.
Temperature-Driven Selection of Predatory Mirid Bugs for Improving Aphid Control in Sweet Pepper Crops
Authors: Pérez-Hedo Meritxell , Pedroche Virginia , Urbaneja Alberto
Published: May 2023

Recent studies have suggested that predatory mirid bugs may be an effective alternative for controlling aphids in sweet pepper greenhouses. This study examined the effect of three constant temperatures (18, 24, and 30 °C) on the life history traits of predatory mirid species Nesidiocoris tenuis, Macrolophus pygmaeus, and Dicyphus bolivari, preying on the aphid Myzus persicae nicotianae in sweet pepper plants. As the temperature increased, the survival rate decreased for M. pygmaeus and D. bolivari, while for N. tenuis, it was the opposite, and their survival increased. When considering all the biological traits studied together, the estimated intrinsic rate of increase (rm) decreased as the temperature increased for M. pygmaeus and D. bolivari. In contrast, the rate increased as the temperature increased for N. tenuis. These results suggest that M. pygmaeus and D. bolivari are better adapted to lower temperatures than N. tenuis, which is more adapted to warm temperatures. The implications of these results for improving the biological control of aphids in sweet pepper greenhouses through the use of mirid bugs are discussed in relation to different temperature regimes.
Correction: Tytła, M. Assessment of Heavy Metal Pollution and Potential Ecological Risk in Sewage Sludge from Municipal Wastewater Treatment Plant Located in the Most Industrialized Region in Poland—Case Study. Int. J. Environ. Res. Public Health 2019, 16, 2430
Authors: Tytła Malwina
Published: May 2023

Missing Funding [...]
Identification of Metabolic Factors and Inflammatory Markers Predictive of Outcome after Total Knee Arthroplasty in Patients with Knee Osteoarthritis: A Systematic Review
Authors: Meert Lotte , Mertens Michel GCAM , Meeus Mira , Vervullens Sophie , Baert Isabel , Beckwée David , Verdonk Peter , Smeets Rob J. E. M.
Published: May 2023

Objective: To identify metabolic factors and inflammatory markers that are predictive of postoperative total knee arthroplasty (TKA) outcome. Method: A systematic search of the existing literature was performed using the electronic databases PubMed, Web of Science and Embase until the 1st of August 2022. Studies that evaluated the influence of metabolic or inflammatory markers (I) on postsurgical outcome (O) in end-stage knee osteoarthritis patients awaiting primary TKA (P) were included in this review. Results: In total, 49 studies were included. Risk of bias of the included studies was low for one study, moderate for 10 studies and high for the remaining 38 studies. Conflicting evidence was found for the influence of body mass index, diabetes, cytokine levels and dyslipidaemia on pain, function, satisfaction and quality of life at more than six months after TKA. Conclusions: Several limitations such as not taking into account known confounding factors, the use of many different outcome measures and a widely varying follow-up period made it challenging to draw firm conclusions and clinical implications. Therefore large-scaled longitudinal studies assessing the predictive value of metabolic and inflammatory factors pre-surgery in addition to the already evidenced risk factors with follow-up of one year after TKA are warranted.
Retrospective Analysis of the Outcome of Hospitalized COVID-19 Patients with Coexisting Metabolic Syndrome and HIV Using Multinomial Logistic Regression
Authors: Mphekgwana Peter M. , Sono-Setati Musa E. , Mokgophi Tania V. , Kifle Yehenew G. , Madiba Sphiwe , Modjadji Perpetua
Published: May 2023

Globally, the coexistence of metabolic syndrome (MetS) and HIV has become an important public health problem, putting coronavirus disease 19 (COVID-19) hospitalized patients at risk for severe manifestations and higher mortality. A retrospective cross-sectional analysis was conducted to identify factors and determine their relationships with hospitalization outcomes for COVID-19 patients using secondary data from the Department of Health in Limpopo Province, South Africa. The study included 15,151 patient clinical records of laboratory-confirmed COVID-19 cases. Data on MetS was extracted in the form of a cluster of metabolic factors. These included abdominal obesity, high blood pressure, and impaired fasting glucose captured on an information sheet. Spatial distribution of mortality among patients was observed; overall (21–33%), hypertension (32–43%), diabetes (34–47%), and HIV (31–45%). A multinomial logistic regression model was applied to identify factors and determine their relationships with hospitalization outcomes for COVID-19 patients. Mortality among COVID-19 patients was associated with being older (≥50+ years), male, and HIV positive. Having hypertension and diabetes reduced the duration from admission to death. Being transferred from a primary health facility (PHC) to a referral hospital among COVID-19 patients was associated with ventilation and less chance of being transferred to another health facility when having HIV plus MetS. Patients with MetS had a higher mortality rate within seven days of hospitalization, followed by those with obesity as an individual component. MetS and its components such as hypertension, diabetes, and obesity should be considered a composite predictor of COVID-19 fatal outcomes, mostly, increased risk of mortality. The study increases our understanding of the common contributing variables to severe manifestations and a greater mortality risk among COVID-19 hospitalized patients by investigating the influence of MetS, its components, and HIV coexistence. Prevention remains the mainstay for both communicable and non-communicable diseases. The findings underscore the need for improvement of critical care resources across South Africa.
COVID-19 Vaccine Hesitancy: A Global Public Health and Risk Modelling Framework Using an Environmental Deep Neural Network, Sentiment Classification with Text Mining and Emotional Reactions from COVID-19 Vaccination Tweets
Authors: Qorib Miftahul , Oladunni Timothy , Denis Max , Ososanya Esther , Cotae Paul
Published: May 2023

Popular social media platforms, such as Twitter, have become an excellent source of information with their swift information dissemination. Individuals with different backgrounds convey their opinions through social media platforms. Consequently, these platforms have become a profound instrument for collecting enormous datasets. We believe that compiling, organizing, exploring, and analyzing data from social media platforms, such as Twitter, can offer various perspectives to public health organizations and decision makers in identifying factors that contribute to vaccine hesitancy. In this study, public tweets were downloaded daily from Tweeter using the Tweeter API. Before performing computation, the tweets were preprocessed and labeled. Vocabulary normalization was based on stemming and lemmatization. The NRCLexicon technique was deployed to convert the tweets into ten classes: positive sentiment, negative sentiment, and eight basic emotions (joy, trust, fear, surprise, anticipation, anger, disgust, and sadness). t-test was used to check the statistical significance of the relationships among the basic emotions. Our analysis shows that the p-values of joy–sadness, trust–disgust, fear–anger, surprise–anticipation, and negative–positive relations are close to zero. Finally, neural network architectures, including 1DCNN, LSTM, Multiple-Layer Perceptron, and BERT, were trained and tested in a COVID-19 multi-classification of sentiments and emotions (positive, negative, joy, sadness, trust, disgust, fear, anger, surprise, and anticipation). Our experiment attained an accuracy of 88.6% for 1DCNN at 1744 s, 89.93% accuracy for LSTM at 27,597 s, while MLP achieved an accuracy of 84.78% at 203 s. The study results show that the BERT model performed the best, with an accuracy of 96.71% at 8429 s.
Intelligence Amplification-Based Smart Health Record Chain for Enterprise Management System
Authors: Velliangiri S. , Karthikeyan P. , Ravi Vinayakumar , Almeshari Meshari , Alzamil Yasser
Published: May 2023

Medical service providers generate many healthcare records containing sensitive and private information about a patient’s health. The patient can allow healthcare service providers to generate healthcare data, which can be stored with healthcare service providers. After some time, if the patient wants to share the healthcare records of one healthcare service provider with another, we can quickly exchange the healthcare record using our approaches. The challenges faced by healthcare service providers are healthcare record sharing, tampering, and insurance fraud. We have developed Health Record Chain for Sharing Medical Data using the modified SHA-512 algorithm. We have evaluated our methods, and our method outperforms in terms of storage cost and total time consumption for health record sharing. The proposed model takes 130 ms to share 100,000 records, 32 ms faster than traditional methods. It also resists various security attacks, as verified by an automated security protocol verification tool.
A Comprehensive Review of the Novel Weighting Methods for Multi-Criteria Decision-Making
Authors: Ayan Büşra , Abacıoğlu Seda , Basilio Marcio Pereira
Published: May 2023

In the realm of multi-criteria decision-making (MCDM) problems, the selection of a weighting method holds a critical role. Researchers from diverse fields have consistently employed MCDM techniques, utilizing both traditional and novel methods to enhance the discipline. Acknowledging the significance of staying abreast of such methodological developments, this study endeavors to contribute to the field through a comprehensive review of several novel weighting-based methods: CILOS, IDOCRIW, FUCOM, LBWA, SAPEVO-M, and MEREC. Each method is scrutinized in terms of its characteristics and steps while also drawing upon publications extracted from the Web of Science (WoS) and Scopus databases. Through bibliometric and content analyses, this study delves into the trend, research components (sources, authors, countries, and affiliations), application areas, fuzzy implementations, hybrid studies (use of other weighting and/or ranking methods), and application tools for these methods. The findings of this review offer an insightful portrayal of the applications of each novel weighting method, thereby contributing valuable knowledge for researchers and practitioners within the field of MCDM.
Engagement with Optional Formative Feedback in a Portfolio-Based Digital Design Module
Authors: Kalaitzopoulou Eirini , Matthews Paul , Mystakidis Stylianos , Christopoulos Athanasios
Published: May 2023

Design skills are considered important in software engineering, and formative feedback may facilitate the learning process and help students master those skills. However, little is known about student usage of and reaction to the feedback and its impact on learning and assessment outcomes. This study explores the effects of optional formative assessment feedback on learners’ performance and engagement by considering LMS interactions, student demographics, personality types, and motivation sources. Forty-five postgraduate students completed an enrolment questionnaire addressing the Big Five personality dimensions, the Situational Motivation Scale and background data. The main methods included monitoring LMS engagement over 10 weeks of teaching and analysing assessment marks to develop student profiles and assess the influence of formative feedback on engagement and performance. The main findings revealed that while formative feedback helped improve marks on portfolio tasks, it did not lead to higher performance overall compared to students who did not receive it. Students seeking feedback engaged more actively with the LMS assessments. Feedback-seeking behaviour was associated with gender, intrinsic motivation, conscientiousness, and extrinsic motivation, although not all associations were significant. The study’s main contributions are in highlighting the impact of formative feedback on performance in linked assessments and in starting to reveal the complex relationship between feedback-seeking behaviour and student characteristics.
Chalcogen Bonds, Halogen Bonds and Halogen···Halogen Contacts in Di- and Tri-iododiorganyltellurium(IV) Derivatives
Authors: Burguera Sergi , Gomila Rosa M. , Bauzá Antonio , Frontera Antonio
Published: May 2023

In this manuscript, we have examined the CSD (Cambridge Structural Database) to investigate the relative ability of Te and I (in practice, the heaviest chalcogen and halogen atoms) in di- and tri-iododiorganyltellurium(IV) derivatives to establish σ-hole interactions. The geometry around the Te(IV) in this type of compound is trigonal bipyramidal where the stereoactive lone pair at Te(IV) occupies one of the equatorial positions. In the solid state, Te(IV) tends to form pseudo-octahedral coordination by establishing strong noncovalent interactions opposite to the two covalent bonds of the equatorial plane. Such contacts can also be classified as chalcogen bonds following the recommendation of the International Union of Pure and Applied Chemistry (IUPAC). Such contacts have been analyzed energetically in this work using density functional theory (DFT) calculations, rationalized using molecular electrostatic potential (MEP) surface analysis and characterized using a combination of the quantum theory of atoms in molecules (QTAIM) and noncovalent interaction plot (NCIplot) computational tools. Finally, the observation of halogen bonds and type I halogen···halogen contacts is also emphasized and compared to the chalcogen bonds. Energy decomposition analysis has also been performed to compare the physical nature of chalcogen, halogen and type I interactions.
Factors Affecting Pollination and Pollinators in Oil Palm Plantations: A Review with an Emphasis on the Elaeidobius kamerunicus Weevil (Coleoptera: Curculionidae)
Authors: Gintoron Christharina S. , Mohammed Muhamad Azmi , Sazali Siti Nurlydia , Deka Elvy Quatrin , Ong Kian Huat , Shamsi Imran Haider , King Patricia Jie Hung
Published: May 2023

Pollination is crucial for oil palm yield, and its efficiency is influenced by multiple factors, including the effectiveness of Elaeidobius kamerunicus weevils as pollinators in Southeast Asia. Weevils transfer pollen between male and female flowers, leading to successful fertilization and fruit development, which contributes to higher oil palm yields and increased production of valuable oil. Understanding and conserving the weevil population is important for sustainable oil palm cultivation practices. The interaction between pollinators, including weevils, and environmental factors is complex, involving aspects such as pollinator behavior, abundance, diversity, and effectiveness, which are influenced by weather, landscape composition, and pesticide use. Understanding these interactions is critical for promoting sustainable pollination practices, including effective pest management and maintaining optimal pollinator populations. This review discusses various abiotic and biotic factors that affect pollination and pollinators in oil palm plantations, with a particular focus on weevils as primary pollinators. Factors such as rainfall, humidity, oil palm species, temperature, endogamy, parasitic nematodes, insecticides, predators, and proximity to natural forests can impact the weevil population. Further research is recommended to fill knowledge gaps and promote sustainable pollination practices in the oil palm industry.
The Genus Heterogynis Rambur, 1866 (Heterogynidae, Lepidoptera): Congruence of Molecular, Morphological and Morphometric Evidence Reveal New Species in Serbia
Authors: Stojanović Dejan V. , Galović Vladislava , Terzin Tomislav , Ačanski Jelena , Vidović Marija , Orlović Saša
Published: May 2023

The Heterogynidae are a small family of moths consisting of a single genus Heterogynis and sixteen described species distributed in the Mediterranean region. A species new to science, Heterogynis serbica sp. nov., is described from the locality of Srebrenac, Mt. Kopaonik, Republic of Serbia, Balkan Peninsula, by applying an integrative taxonomic approach using morpho-anatomical characteristics, wing morphometics and DNA barcoding. Male genitalia, scanning electron micrographs of adult male head anatomy, abdominal tergites/sternites, cocoons and habitats of the closely related species H. serbica sp. nov. and H. zikici are discussed and illustrated. Photographs of adult males and females, cocoons, plants in which the cocoons were found and habitats are shown. Importantly, marked differences in genital structure and other morphological characters were noted. These differences were confirmed with forewing morphometrics and COI-based DNA barcoding results. Additionally, DNA barcodes for H. serbica sp. nov. and H. zikici were compared against previously available data for the genus to evaluate the phylogenetic relationships. We conclude that deep, previously unknown and unexpected intrageneric morphological diversity exists in the genus Heterogynis.
Transplantation for Primary Sclerosing Cholangitis: Outcomes and Recurrence
Authors: Saner Fuat H. , Frey Alexandra , Stüben Björn-Ole , Hoyer Dieter P. , Willuweit Katharina , Daniel Martina , Rashidi-Alavieh Jassin , Treckmann Jurgen W. , Schmidt Hartmut H.
Published: May 2023

Primary sclerosing cholangitis (PSC) is characterized by inflammation of the whole bile duct system. Liver transplantation is only approved as a curative treatment when it comes to end-stage liver disease. The aim of our study was to assess morbidity, survival rates and PSC recurrence and the impact of donor characteristics in long-term follow-up. This was an IRB-approved retrospective study. A total of 82 patients were identified who were transplanted between January 2010 and December 2021 for PSC. Among these patients, 76 adult liver transplant PSC patients and their corresponding donors were analyzed. Three pediatric cases and three adult patients with a follow-up within <1 year were excluded from further analysis. Median (range) age was 47 years (18–70) with a median (range) lab-MELD of 16 (7–40). Median (range) ICU and hospital stays were 4.6 days (0–147) and 21 days (1–176), respectively. The majority of patients suffered from Crohn’s disease or ulcerative colitis as a concomitant comorbidity (65.8%). The ten-year survival rate was 74.6%. A significantly lower lab-MELD score was identified in patients surviving for > 10 years (15 vs. 22, p = 0.004). Most patients (65%) passed in the first year following transplantation, with primary non-function (PNF), sepsis and arterial thrombosis being the most common causes of death. Donor characteristics did not affect patient survival. Patients with PSC show excellent 10-year survival rates. While the lab-MELD score significantly affected long term outcomes, donor characteristics did not affect survival rates.
The Efficacy and Safety of Rituximab in Patients with Idiopathic Inflammatory Myopathy-Associated Interstitial Lung Disease: Case Series
Authors: Jang Youngeun , Yoon Hee-Young , Kim Hyun-Sook
Published: May 2023

Idiopathic inflammatory myopathy (IIM)-associated interstitial lung disease (ILD) is often rapidly progressive with a poor prognosis; however, no standard therapeutic regimen has been identified. This study aimed to investigate the efficacy and safety of rituximab in IIM-ILD patients. Five patients who had been administered rituximab for IIM-ILD at least once between August 2016 and November 2021 were included. Lung function decline was compared one year before and after rituximab. Disease progression, defined as a greater than 10% relative decline in forced vital capacity (FVC) compared to the baseline, was also compared before and after treatment. Adverse events were recorded for safety analysis. Five IIM-ILD patients received eight cycles. FVC-predicted values significantly decreased from 6 months before rituximab administration to those at the baseline (54.1% predicted (pre-6 months) vs. 48.5% predicted (baseline), p = 0.043); however, the FVC decline stabilized after rituximab. The rate of disease progression before rituximab showed a tendency to decrease after rituximab (75% (before) vs. 12.5% (6 months after, p = 0.059) vs. 14.3% (12 months after, p = 0.102)). Three adverse events developed, but none resulted in death. Rituximab can stabilize lung function decline with tolerable safety in Korean IIM patients with refractory ILD.
Vascular Inflammatory Markers as Predictors of Peripheral Arterial Disease Patients’ Quality-of-Life Changes after Endovascular Treatment
Authors: Wachsmann-Maga Agnieszka , Maga Mikołaj , Polczyk Romuald , Włodarczyk Aleksandra , Pasieka Patrycja , Terlecki Karol , Maga Paweł
Published: May 2023

The association between chronic inflammation and depression, anxiety, anhedonia, and quality of life (QoL) has been recently emphasized. However, the pathophysiology of this relationship remains unsolved. This study aims to assess the dependence between vascular inflammation represented by eicosanoid concentration and quality of life in patients with peripheral arterial disease (PAD). A total of 175 patients undergoing endovascular treatment due to lower limbs ischemia were covered with eight years of observation after the endovascular procedure, including ankle-brachial index (ABI), color Doppler ultrasound examination, urinary leukotriene E4 (LTE4), thromboxane B2 (TXB2) and 5-Hydroxyeicosatetraenoic acid (5-HETE) measurement and quality-of-life assessment with VascuQol-6. The baseline concentrations of LTE4 and TXB2 reversely correlated with preoperative VascuQol-6 and were predictive of the postoperative values of VascuQol-6 at each follow-up. At every follow-up timepoint, the results of VascuQol-6 reflected the LTE4 and TXB2 concentrations. Higher concentrations of LTE4 and TXB2 were correlated with lower life quality during the next follow-up meeting. Changes in VascuQol-6 at eight years vs. preoperative values were reversely related to the preoperative concentrations of LTE4 and TXB2. This is the first study to confirm that changes in life quality in PAD patients undergoing endovascular treatment are highly dependent on eicosanoid-based vascular inflammation.
Atopic Dermatitis in Latin America: Considerations on Epidemiology, Clinical and Laboratory Features, Ethnic/Racial Variations, and Therapeutic Management
Authors: Soares Georgia Biazus , Orfali Raquel Leao , Averbach Beatriz Lacerda , Yosipovitch Gil , Aoki Valeria
Published: May 2023

Latin America (LA) encompasses about 8.5% of the world’s population, exhibits ethnic/racial heterogeneity and social inequality. We hereby present a 20-year literature review (2004–2023) on epidemiology, diagnosis, clinical and laboratory features, quality of life and management of atopic dermatitis (AD) in LA. Highest AD prevalence for children aged 6–7 years was reported in Ecuador (22.5%) and Colombia (20.9%), for adolescents in Colombia (24.6%) and for all ages, in Brazil (20.1%). Regions with a predominantly Black population in LA varied significantly, ranging from 4.4% in Northern Brazil to 10.1% in Cuba, indicating genetic variation among African subgroups. Filaggrin loss-of-function mutations showed variants seen in Europeans in 9.3% of Chilean patients and studies in Brazil revealed impaired expression of filaggrin and claudin-1 in the skin but increased expression in conjunctival epithelia of AD patients. The most reported AD features included erythema, pruritus, and dry skin, with marked lichenification. Severe pruritus was reported by 54.4% of patients and a high impact on quality of life was detected in 50% of adults with AD. In Brazilian referral hospitals, 65.6% of patients were classified as having severe AD, and 56% had one or more hospitalizations during their lifetime, indicating a need for better disease control. Diagnosing AD is challenging due to broad clinical features, ethnoracial variations and lack of universal diagnostic criteria. Furthermore, lack of physician training, barriers to medication access, and socioeconomic inequalities hinder effective disease management in LA.
Pulmonary Arterial Hypertension Associated with Portal Hypertension and HIV Infection: Comparative Characteristics and Prognostic Predictors
Authors: Dardi Fabio , Guarino Daniele , Cennerazzo Francesco , Ballerini Alberto , Magnani Ilenia , Bertozzi Riccardo , Donato Federico , Martini Giulia , Manes Alessandra , Galiè Nazzareno , Palazzini Massimiliano
Published: May 2023

Background: Pulmonary arterial hypertension (PAH) may complicate both portal hypertension (Po-PAH) and HIV infection (HIV-PAH). These two conditions, however, frequently coexist in the same patient (HIV/Po-PAH). We evaluated clinical, functional, hemodynamic characteristics and prognostic parameters of these three groups of patients. Methods: We included patients with Po-PAH, HIV-PAH and HIV/Po-PAH referred to a single center. We compared clinical, functional and hemodynamic parameters, severity of liver disease [Child–Turcotte–Pugh (CTP) and Model for End-stage Liver Disease-Na (MELD-Na) scores], CD4 count and highly active antiretroviral therapy (HAART) administration. Prognostic variables were identified through Cox-regression analysis. Results: Patients with Po-PAH (n = 128) were the oldest, patients with HIV-PAH (n = 41) had the worst hemodynamic profile and patients with HIV/Po-PAH (n = 35) had the best exercise capacity. Independent predictors of mortality were age and CTP score for Po-PAH, HAART administration for HIV-PAH, MELD-Na score and hepatic venous-portal gradient for HIV/Po-PAH. Conclusions: Patients with HIV/Po-PAH are younger and have a better exercise capacity than patients with Po-PAH, have a better exercise capacity and hemodynamic profile compared to patients with HIV-PAH, and their prognosis seems to be related to the hepatic disease rather than to HIV infection. The prognosis of patients with Po-PAH and HIV-PAH seems to be related to the underlying disease.
Retrograde Autologous Talar Osteocancellous Bone Grafting for the Treatment of Osteochondral Lesions of the Talus: A Technical Note
Authors: Yokoe Takuji , Tajima Takuya , Yamaguchi Nami , Morita Yudai , Chosa Etsuo
Published: May 2023

Osteochondral lesions of the talus (OLT) are common injuries in young athletes. Various kinds of surgical procedures are available for orthopaedic surgeons, but which surgical technique is the best remains controversial. Many surgical procedures require malleolar osteotomy to obtain appropriate surgical exposure to the OLT because of the anatomic characteristics of the ankle joint. However, malleolar osteotomy is invasive and has a potential risk of complications, such as tibial chondral damage and pseudoarthrosis. This article aims to introduce a novel surgical procedure for the treatment of OLTs: retrograde autologous talar osteocancellous bone grafting without the need for osteotomy and harvesting a graft from anywhere other than the talus. First, an arthroscopic evaluation is performed to verify the location, size, and cartilage quality of the OLT as well as concomitant lesions. After confirming the position of the guide pin using a guide device arthroscopically, a talar osteocancellous bone plug is harvested using a coring reamer. The OLT of the harvested talar bone plug is removed, and under arthroscopy, the talar osteocancellous bone plug is retrogradely inserted into the talar bone tunnel. To stabilize the implanted bone plug, one or two bioabsorbable pins are inserted from the lateral wall of the talus while applying counterforce to the articular surface of the bone plug. The present surgical technique can minimally invasively address the OLT without the need for malleolar osteotomy and harvesting a graft from the knee joint or iliac bone.
Morpho-Functional Assessment of Retinal Ganglion Cells and Visual Pathways in Patients with Optic Disc Drusen: Superficial Drusen Visible Height as a Marker of Impairment
Authors: Antonelli Giulio , Ziccardi Lucia , Barbano Lucilla , Di Renzo Antonio , Parisi Vincenzo
Published: May 2023

The aim of this study was to assess the morpho-functional involvement of the retinal ganglion cells (RGCs) and of the visual pathways in patients with superficial (ODD-S) or deep (ODD-D) optic disc drusen. This study enrolled 17 patients with ODD (mean age of 59.10 ± 12.68 years) providing 19 eyes and 20 control subjects (mean age 58.62 ± 8.77 years) providing 20 eyes. We evaluated the following: best-corrected visual acuity, visual field mean deviation (MD), the amplitude (A) of Pattern Electroretinogram (PERG), the implicit time (IT) and A of Visual Evoked Potentials (VEPs), retinal nerve fiber layer thickness (RNFL-T) and ganglion cell thickness (GC-T). In ODD-S eyes, the drusen visible height was measured. ODD-D and ODD-S were detected in 26.3% and 73.7% of ODD eyes, respectively. Significantly (p < 0.01) reduced MD, PERG A, VEP amplitude, RNFL-T and GC-T values and significantly (p < 0.01) increased VEP IT values were found in the ODD Group as compared to the Control one. In the ODD Group, no significant correlation (p > 0.01) between PERG As and VEP ITs was found. In ODD-S, the visible height was significantly correlated (p < 0.01) with reduced MD, PERG As and RNFL-T and with increased PSD and VEP IT values. Our findings suggest that ODD might induce morpho-functional changes in RGCs and their fibers and an unrelated visual pathway dysfunction leading or not leading to visual field defects. The observed morpho-functional impairment should be ascribed to an alteration in retrograde (from the axons to the RGCs) and anterograde (from the RGCs up to the visual cortex) axoplasmic transport. In ODD-S eyes, a minimum visible height of 300 microns represented the threshold for the abnormalities, suggesting that “the higher the ODD, the worse the impairment”.
Clinical Implications of the Association between Respiratory and Gastrointestinal Disorders in Migraine and Non-Migraine Headache Patients
Authors: Kim Jong-Ho , Lee Yeonkyeong , Kwon Young-Suk , Sohn Jong-Hee
Published: May 2023

Headaches, particularly migraine, are associated with gastrointestinal (GI) disorders. In addition to the gut–brain axis, the lung–brain axis is suspected to be involved in the relationship between pulmonary microbes and brain disorders. Therefore, we investigated possible associations of migraine and non-migraine headaches (nMH) with respiratory and GI disorders using the clinical data warehouse over 11 years. We compared data regarding GI and respiratory disorders, including asthma, bronchitis, and COPD, among patients with migraine, patients with nMH, and controls. In total, 22,444 patients with migraine, 117,956 patients with nMH, and 289,785 controls were identified. After adjustment for covariates and propensity score matching, the odds ratios (ORs) for asthma (1.35), gastroesophageal reflux disorder (1.55), gastritis (1.90), functional GI disorder (1.35), and irritable bowel syndrome (1.76) were significantly higher in patients with migraine than in controls (p = 0.000). The ORs for asthma (1.16) and bronchitis (1.33) were also significantly higher in patients with nMH than in controls (p = 0.0002). When the migraine group was compared with the nMH group, only the OR for GI disorders was statistically significant. Our findings suggest that migraine and nMH are associated with increased risks of GI and respiratory disorders.
Recent Advances in Tissue-Engineered Cardiac Scaffolds—The Progress and Gap in Mimicking Native Myocardium Mechanical Behaviors
Authors: Baghersad Somayeh , Sathish Kumar Abinaya , Kipper Matt J. , Popat Ketul , Wang Zhijie
Published: May 2023

Heart failure is the leading cause of death in the US and worldwide. Despite modern therapy, challenges remain to rescue the damaged organ that contains cells with a very low proliferation rate after birth. Developments in tissue engineering and regeneration offer new tools to investigate the pathology of cardiac diseases and develop therapeutic strategies for heart failure patients. Tissue -engineered cardiac scaffolds should be designed to provide structural, biochemical, mechanical, and/or electrical properties similar to native myocardium tissues. This review primarily focuses on the mechanical behaviors of cardiac scaffolds and their significance in cardiac research. Specifically, we summarize the recent development of synthetic (including hydrogel) scaffolds that have achieved various types of mechanical behavior—nonlinear elasticity, anisotropy, and viscoelasticity—all of which are characteristic of the myocardium and heart valves. For each type of mechanical behavior, we review the current fabrication methods to enable the biomimetic mechanical behavior, the advantages and limitations of the existing scaffolds, and how the mechanical environment affects biological responses and/or treatment outcomes for cardiac diseases. Lastly, we discuss the remaining challenges in this field and suggestions for future directions to improve our understanding of mechanical control over cardiac function and inspire better regenerative therapies for myocardial restoration.
Evaluation of Polylactic Acid Polymer as a Substrate in Rectenna for Ambient Radiofrequency Energy Harvesting
Authors: Linge Pangsui Usifu , Gerges Tony , Bevilacqua Pascal , Duchamp Jean-Marc , Benech Philippe , Verdier Jacques , Lombard Philippe , Cabrera Michel , Tsafack Pierre , Mieyeville Fabien , Allard Bruno
Published: May 2023

This work details the design and experimental characterization of a 2D rectenna for scavenging radio frequency energy at 2.45 GHz (WiFi band), fabricated on polylactic acid polymer (PLA) using a plastronics approach. PLA is the RF substrate of both antenna and rectifier. The two transmission line (TTL) approach is used to characterize the substrate properties to be considered during design. A linearly polarized patch antenna with microstrip transmission feeding is connected to a single series diode rectifier through a T-matching network. The antenna has simulated and measured gain of 7.6 dB and 7.5 dB, respectively. The rectifier has a measured DC output power of 0.96 μW at an optimal load of 2 kΩ under RF input power of −20 dBm at 2.45 GHz. The power conversion efficiency is 9.6% in the latter conditions for a 54 × 36 mm patch antenna of a 1.5 mm thick PLA substrate obtained from additive manufacturing. The power conversion efficiency reaches a value of 28.75% when the input power is −10 dBm at 2.45 GHz. This corresponds to a peak DC power of 28.75 μW when the optimal load is 1.5 kΩ. The results compare significantly with the ones of a similar rectenna circuit manufactured on preferred RF substrate.
Modelling, Linearity Analysis and Optimization of an Inductive Angular Displacement Sensor Based on Magnetic Focusing in Ships
Authors: Li Zhipeng , Wang Bonan , Wang Xianbin , Zhang Chao , Meng Xu
Published: May 2023

A sensor for measuring the crankshaft angle of the main engine in ships is designed. Compared with the existing crankshaft angle encoder, this design’s advantage is that there is no need to add a gear system at the free end of the crankshaft, reducing machining complexity. The purpose of providing high angle resolution over a wide speed range is achieved. Inductive angular displacement sensors (IADSs) require an eddy current magnetic field as a medium to generate the induced voltage. The induced voltage also requires a complex linearization calculation to obtain a linear relationship between angle and voltage. Therefore, a model of the inductive angular displacement sensor based on magnetic focusing (IADSMF) is proposed. Magnetic focusing is introduced into the IADS to replace the eddy current magnetic field with a focusing magnetic field. The main disadvantage of traditional IADSs, which is that they cannot reduce the eddy current magnetic field, is mitigated. An approximate square−shaped focusing magnetic field (12.4 × 12.4 mm2) is formed using the magnetic field constraint of the magnetic conductor. When the receiving coil undergoes a position change relative to the square−shaped focusing magnetic field, the voltage generated via the receiving coil is measured using the electromagnetic induction principle to achieve angular displacement measurement. A mathematical model of the IADSMF is derived. Induced voltages at different frequencies and rotational speeds are simulated and analyzed via MATLAB. The results show that frequency is the main factor affecting the induced voltage amplitude. The sensitivity of the IADSMF is 0.2023 mV/°. The resolution and measurement of the IADSMF range from 0.06° and 0–360°. Compared with a conventional planar coil−based IADS, the eddy current loss is reduced from 2.1304 to 0.3625 W. Direct linearization of the angular displacement with the induced voltage is achieved through designing a square−shaped focusing field and receiving coil. After optimizing the sensor structure with the optimization algorithm, the linearity error is 0.6012%. Finally, this sensor provides a theoretical basis and research ideas for IADS development in ships and navigation.