bluuebunny/crossref_metadata_2025 huggingface dataset:
DEFICIENCIA EN LOS OPERADORES DEL SISTEMA DE JUSTICIA PARA PREVENIR Y ERRADICAR EL DELITO DE FEMINICIDIO EN EL PODER JUDICIAL DE SAN IGNACIO, 2018
Authors: Saavedra Novoa Luis Yonel
Published: September 2023

El objeto de esta investigación es determinar las falencias de los operadores de justicia para prevenir y erradicar el delito de homicidio de mujeres en el sistema de justicia de San Ignacio; incluyendo la sanción sistemática en los procesos judiciales y en las acciones en torno a los casos de violencia contra las mujeres ya que la mayoría de estos casos no son efectivamente investigados, sancionados y reparados. Por otro lado, se diseñó una investigación básica de tipo cualitativa descriptiva simple con un diseño no empírico; De igual forma, para el análisis de datos se utilizó estadística descriptiva con una población de 32 jueces, fiscales y abogados, con una muestra de selección no fuego de 32 profesionales del derecho; Del mismo modo, se utilizó una herramienta de cuestionario de 20 ítems. Llegando a la conclusión que el delito de suicidio no protege la vida de las mujeres según la Tabla 1 y Figura 1, el 50% muy en desacuerdo, el 22% en desacuerdo, el 13% muy de acuerdo, el 9% en desacuerdo y por último el 6% muy de acuerdo.
Study on ecotourism development in Gilgit Baltistan, Pakistan
Authors: Ali Fahad
Published: September 2023

Gilgit Baltistan is representative of the correlation between eco-tourism and local economic development in Pakistan, but there is a lack of research on eco-tourism in this region. This paper aims to provide theoretical basis and strategic direction for the coordinated development of tourism development, ecological protection, economic development, social benefits, and ecological benefits in this region. This paper systematically analyzes the stage of transformation and upgrading of local ecotourism development, and deeply explores the problems and causes. The popularity of cultural tourism brings new opportunities for Gilgit Baltistan, but some practical problems and conflicts are constantly exposed in the process of tourism development. This study tried to address that how to develop the cultural ecology of Gilgit Baltistan in a protective way and realize the harmonious development of economic value and ecological society has thrown up a difficult problem for the construction of eco-tourism in Gilgit Baltistan. This paper uses SWOT analysis to extract and summarize the internal strengths and weaknesses, external opportunities and challenges of Gilgit Baltistan's eco-tourism, so as to provide appropriate strategies for the development of local eco-tourism and clarify development goals and priorities.
提高建筑工程施工质量控制的有效策略探究
Authors: 张 广华
Published: September 2023

目前，部分建筑企业逐渐意识到施工质量控制对施工项目的重要性，而在实际施工管理过程中仍局限于传统的管理模式和理念，且管施工管理方式的落后，也导致建筑工程中频繁出现问题，企业需根据自身实际发展情况出发，强化施工管理模式，提高施工质量控制水平，才能在市场中占据有利地位，促进企业的健康发展。文章对提高建筑工程施工质量控制的有效策略进行探究。
Pelatihan Desain Presentasi Dengan Canva Pada DKM Darul Hikmah Depok
Authors: Suryani Nining , Yusnaeni Wina , Basri Hasan
Published: September 2023

Tuntutan organisasi atau instansi bisa terus aktif pada kegiatan internal maupun eksternal. Menyikapi hal ini, sebuah yayasan sosial pun memerlukan upaya jitu agar yayasan dapat diterima dengan baik serta dapat memiliki brand image yang baik di mata masyarakat. Trend saat ini yayasan harus bergerak memanfaatkan teknologi, terutama dalam melakukan langkah manajemen dalam berupaya melakukan branding dan operasional. Dengan pengelolaan teknologi yang baik seperti pembuatan design pengumuman atau informasi yayasan dengan aplikasi, akan menciptakan iklim Teknologi Informasi yang stabil dan membangun kepercayaan terhadap masyarakat dalam mencapai visi misi organisasi dalam suatu yayasan. Permasalahan yang ada pada pengurus DKM Darul Hikmah ini antara lain kendala dalam pembuatan presentasi,  minim informasi komunikasi, kurang pengetahuan terhadap fitur yang responsive dan sebagainya. Dari temuan-temuan yang ada, perlu diadakan pelatihan desain presentasi menggunakan canva pada DKM Darul Hikmah, agar dapat menarik sebanyak mungkin para donatur dan publikasi informasi kepada masyarakat. Dengan hasil kuisoner sebelum pelatihan dilakukan,  95% dari peserta tidak paham bagaimana membuat presentasi menggunakan canva dan setelah diberikannya pelatihan 60% dari peserta paham bagaimana membuat presentasi menggunakan canva, pelatihan ini diharapkan dapat memberikan pengetahuan aplikasi canva sebagai media pembuatan desain presentasi mudah dan cantik serta media informasi komunikasi DKM Darul Hikmah yang dapat memberikan atensi, kepercayaan, knowledge kepada para audiens.
Pelatihan Manajemen Organisasi Untuk Mengoptimalkan Kinerja Pada Pengurus Yayasan Pendidikan Islam Arrohmah Kota Bogor
Authors: Vina Islami  , Rani Rani , Syahrir Syahrir
Published: September 2023

Yayasan Pendidikan Islam Arrohmah adalah yayasan yang bergerak dibidang pendidikan agama Islam melalui Madrasah Tsanawiyah Arrohmah yang ada di kota Bogor, dan pengurusnya adalah orang-orang yang menempati struktur dalam organisasi yayasan dan menjalankan fungsinya sesuai dengan jobdesk nya. Peningkatan kinerja pengurus sangat diperlukan untuk menunjang keberhasilan yayasan dalam mencapai tujuannya. Untuk itu perlu dilakukan pelatihan manajemen organisasi bagi pengurus yayasan. Dengan semakin baik keterampilan manajemen organisasi yang dimiliki oleh para pengurus maka akan meningkatkan kinerja mereka dan selanjutnya membuat yayasan dapat menyelenggarakan pendidikan yang semakin baik pula. Pelatihan ini dilaksanakan secara offline atau langsung kepada pengurus Yayasan  Pendidikan Islam Arrohman. Target luaran yang ingin dicapai adalah adanya peningkatan pengetahuan dan kemampuan pengurus Yayasan Pendidikan Islam Arrohman dalam membuat program kerja, peningkatan efektifitas kerja sehingga terjadi peningkatan kinerja secara keseluruhan
Penyuluhan Aplikasi Dan Peranan Teknologi Informasi dan Komunikasi Bagi Gerakan Pemuda (GP) Anshor PAC Ciledug
Authors: Kristiana Titin , Handayani Rani Irma , Haryanti Tuti , Frieyadie Frieyadie
Published: September 2023

Teknologi informasi sering disebut sebagai sebuah panduan antara komputer dan komunikasi yang dimana kekuatan dari suatu komponen pengelolaan data dan pada sistem telekomunikasi yang secara digital. Dari kemampuan teknologi ini bisa merubah suatu organisasi yang dimana pada desain nya telah ditentukan melalui batasan batasan horizontal maupun vertikal atau batasan dari luar yang diterapkan oleh struktur pada sebuah organisasi tersebut dengan ditentukan sebelumnya. Berdasarkan analisa lapangan dan wawancara dengan pengurus organisasi Gerakan Pemuda (GP) Ansor Ciledug dapat disimpulkan bahwa terdapat kurangnya pengetahuan akan pengguna teknologi informasi dan komunikasi yang disebabkan oleh faktor usia dan juga kurang dalam mengoperasikan teknologi informasi yang baru oleh karena itu diperlukan penyuluhan mengenai penggunaan teknlogi informasi yang terbaru. Hasil dan manfaat dari kegiatan pengabdian pada masyarakat telah diberikan pengetahuan tentang manfaat teknologi yang sedang berkembang di era Industri 4.0 yang sarat dengan kemajuan teknologi informasi dan komunikasi. Kegiatan ini telah membangkitkan semangat dan motivasi para peserta untuk terus belajar dengan pemanfaatan teknologi informasi dan komunikasi. Berdasarkan hasil evaluasi yang terukur pelaksanaan kegiatan pengabdian masyarakat ini sebanyak 86% peserta menyatakan telah memahami luaran kegiatan dan berpendapat bahwa kegiatan ini telah sesuai dengan harapan.
Pengaruh Budaya Organisasi dan Motivasi Kerja terhadap Kinerja Pegawai pada Sekretariat Daerah Kabupaten Way Kanan
Authors: Suyarti Sri , Parela Epi
Published: September 2023

Penelitian ini bertujuan untuk mengetahui pengaruh budaya organisasi dan motivasi kerjaterhadap kinerja pegawai pada Sekretariat Daerah Kabupaten Way Kanan.Adapun jenis Penelitian yang digunakan dalam penelitian ini adalah model penelitianExplanatory. Penelitian ini menggunakan 56 responden penelitian. Ada tiga variabel dalampenelitian ini yaitu: 2 (dua) Variabel bebas (X1 dan X2) dan 1 (satu) variabel terikat dimanabudaya organisasi (X1) dan motivasi kerja (X2) sebagai variabel bebas dan kinerja pegawai(Y) sebagai variabel terikat.Berdasarkan analisis data telah ditemukan jawaban hipotesis yakni sebagai berikut; Terdapatpengaruh budaya organisasi (X1) terhadap kinerja pegawai (Y), dengan tingkat pengaruhsebesar 50.6%. Terdapat pengaruh motivasi kerja (X2) terhadap kinerja pegawai (Y) dengantingkat pengaruh sebesar 47.3%. Terdapat pengaruh budaya organisasi (X1) dan motivasikerja (X2) secara bersama-sama terhadap kinerja pegawai (Y) dengan tingkat pengaruhsebesar 67.5%.
Analisis Kinerja Pegawai Ditinjau dari Indikator Disiplin dan Motivasi (Studi Kasus Pada Unit Pelaksana Teknis Dinas Penyuluhan Pertanian Kecamatan Negara Batin Kabupaten Way Kanan)
Authors: Pramono Arief , Suhendi Andreas
Published: September 2023

Penelitian ini bertujuan untuk menganalisis kinerja pegawai ditinjau dari disiplin kerja danmotivasi kerja di Unit Pelaksana Teknis Dinas Penyuluhan Pertanian Kecamatan NegaraBatin Kabupaten Way Kanan.Penelitian yang dilaksanakan adalah penelitian deskriptif kuantitatif. Jenis penelitian iniadalah penelitian yang bermaksud membuat pemaparan secara sistimatis, faktual, dan akuratmengenai fakta – fakta dan sifat – sifat populasi tertentu. Penelitian ini menggunakan 24responden penelitian. Ada tiga variabel dalam penelitian ini yaitu: 2 (dua) variabel bebas (X1dan X2) dan 1 (satu) variabel terikat, dimana disiplin kerja (X1) dan motivasi kerja (X2)sebagai variabel bebas dan kinerja pegawai (Y) sebagai variabel terikat.Berdasarkan hasil pengolahan data telah ditemukan jawaban hipotesis, yakni sebagai berikut;terdapat pengaruh disiplin kerja (X1) terhadap kinerja pegawai (Y) dengan tingkat pengaruh(R-square) sebesar 37,8%. Terdapat pengaruh motivasi kerja (X2) terhadap kinerja pegawai(Y) dengan tingkat pengaruh sebesar 31,1%. Terdapat pengaruh disiplin kerja (X1) danmotivasi kerja (X2) secara bersama-sama terhadap kinerja pegawai (Y) dengan tingkatpengaruh sebesar 48,8%.
FEMALE WRITER IN LATIN AMERICA: REFLECTION ON THE INFLUENCE OF FEMINISM AND ITS IMPORTANCE IN CONTEMPORARY LITERATURE
Authors: Costa Thayssa Duarte
Published: September 2023

The cultural, political, social, economic marginalization of women and the little intellectual authority granted to them negatively influenced the writing, publication and dissemination of female writers’ materials, but with the transcendental changes in Latin America, greatly influenced by the feminist movement, it made with a new configuration of social and cultural spaces, favoring the consolidation of feminist organizations and popular women's organizations. In addition, the increasing inclusion of women in the labor market reflected changes in the family and created a new collective imagination. With that in mind, this work aimed to evaluate and raise a reflection on the evolution of female writer literature in Latin America and the impacts generated in today's productions, the 21st century. Through research carried out through books and digital articles in a period from 2010 to 2022, it was found that women are gaining a little more space in the publishing market and becoming avid readers, however, even as the majority in the search for books, women still do not dominate the production of works in Latin American countries and still do not influence the favoritism of the male public.
Scarcity of Women in Interventional Radiology in SubSaharan Africa: Survey and Insights
Authors: Ukweh Ofonime , Omofoye Toma S. , Naif Azza , Rajab Latifa , Chan Shin Mei , Gichoya Judy , Gaupp Fabian Laage , Newsome Janice
Published: September 2023

Purpose: Globally, women are underrepresented in Interventional Radiology (IR) and calls have been made to increase gender equity. In sub-Saharan Africa specifically, IR is a rapidly emerging field. However, concerns have been raised about the lack of women in IR in the region. The purpose of this study was to assess the state of women in IR in sub-Saharan Africa, with attention to their training experiences, and perceived barriers, to identify opportunities to increase gender equity.
Methods: We distributed a survey to all identifiable female IR physicians and trainees in sub-Saharan Africa (SSA). The survey included questions on demographics, training experiences, barriers faced professionally, and suggestions for encouraging more women in Africa to pursue IR. 
Results: Eight women in IR in SSA were identified, six of whom responded to the survey (75% response rate). Commonly cited perceived barriers include lack of training opportunities, gender underrepresentation and societal expectations. Suggestions for increasing women's participation in IR can be increased by creating more training opportunities in Africa, including gender-specific opportunities, integrating IR into diagnostic radiology training programs, developing mentoring programs, and concerted efforts by professional societies to establish dedicated committees, scholarships and sponsorship of women. 
Conclusions: While interventional radiologists are few in SSA, gender disparities already exist. As increasing the number of IR physicians in low resource areas is essential to addressing health disparities, and women in IR frequently treat women's health conditions, including maternal mortality, building physician capacity in a gender-sensitive manner is essential.
Fat body-specific reduction of CTPS alleviates HFD-induced obesity
Authors: Liu Jingnan , Zhang Yuanbing , Wang Qiao-Qi , Zhou Youfang , Liu Ji-Long
Published: September 2023

Obesity induced by high-fat diet (HFD) is a multi-factorial disease including genetic, physiological, behavioral, and environmental components. Drosophila has emerged as an effective metabolic disease model. Cytidine 5'-triphosphate synthase (CTPS) is an important enzyme for the de novo synthesis of CTP, governing the cellular level of CTP and the rate of phospholipid synthesis. CTPS is known to form filamentous structures called cytoophidia, which are found in bacteria, archaea, and eukaryotes. Our study demonstrates that CTPS is crucial in regulating body weight and starvation resistance in Drosophila by functioning in the fat body. HFD-induced obesity leads to increased transcription of CTPS and elongates cytoophidia in larval adipocytes. Depleting CTPS in the fat body prevented HFD-induced obesity, including body weight gain, adipocyte expansion, and lipid accumulation, by inhibiting the PI3K-Akt-SREBP axis. Furthermore, a dominant-negative form of CTPS also prevented adipocyte expansion and downregulated lipogenic genes. These findings not only establish a functional link between CTPS and lipid homeostasis but also highlight the potential role of CTPS manipulation in the treatment of HFD-induced obesity.
Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons
Authors: Subkhangulova Aygul , Gonzalez-Lozano Miguel A , Groffen Alexander JA , van Weering Jan RT , Smit August B , Toonen Ruud F , Verhage Matthijs
Published: September 2023

Tomosyn is a large, non-canonical SNARE protein proposed to act as an inhibitor of SNARE complex formation in the exocytosis of secretory vesicles. In the brain, tomosyn inhibits the fusion of synaptic vesicles (SVs), whereas its role in the fusion of neuropeptide-containing dense core vesicles (DCVs) is unknown. Here, we addressed this question using a new mouse model with a conditional deletion of tomosyn (Stxbp5) and its paralogue tomosyn-2 (Stxbp5l). We monitored DCV exocytosis at single vesicle resolution in tomosyn-deficient primary neurons using a validated pHluorin-based assay. Surprisingly, loss of tomosyns did not affect the number of DCV fusion events but resulted in a strong reduction of intracellular levels of DCV cargos, such as neuropeptide Y (NPY) and brain-derived neurotrophic factor (BDNF). BDNF levels were largely restored by re-expression of tomosyn but not by inhibition of lysosomal proteolysis. Tomosyn’s SNARE domain was dispensable for the rescue. The size of the trans-Golgi network and DCVs was decreased, and the speed of DCV cargo flux through Golgi was increased in tomosyn-deficient neurons, suggesting a role for tomosyns in DCV biogenesis. Additionally, tomosyn-deficient neurons showed impaired mRNA expression of some DCV cargos, which was not restored by re-expression of tomosyn and was also observed in Cre-expressing wild-type neurons not carrying loxP sites, suggesting a direct effect of Cre recombinase on neuronal transcription. Taken together, our findings argue against an inhibitory role of tomosyns in neuronal DCV exocytosis and suggests an evolutionary conserved function of tomosyns in the packaging of secretory cargo at the Golgi.
Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation
Authors: Asai Rieko , Prakash Vivek N , Sinha Shubham , Prakash Manu , Mikawa Takashi
Published: September 2023

Large-scale cell flow characterizes gastrulation in animal development. In amniote gastrulation, particularly in avian gastrula, a bilateral vortex-like counter-rotating cell flow, called ‘polonaise movements’, appears along the midline. Here, through experimental manipulations, we addressed relationships between the polonaise movements and morphogenesis of the primitive streak, the earliest midline structure in amniotes. Suppression of the Wnt/planar cell polarity (PCP) signaling pathway maintains the polonaise movements along a deformed primitive streak. Mitotic arrest leads to diminished extension and development of the primitive streak and maintains the early phase of the polonaise movements. Ectopically induced Vg1, an axis-inducing morphogen, generates the polonaise movements, aligned to the induced midline, but disturbs the stereotypical cell flow pattern at the authentic midline. Despite the altered cell flow, induction and extension of the primitive streak are preserved along both authentic and induced midlines. Finally, we show that ectopic axis-inducing morphogen, Vg1, is capable of initiating the polonaise movements without concomitant PS extension under mitotic arrest conditions. These results are consistent with a model wherein primitive streak morphogenesis is required for the maintenance of the polonaise movements, but the polonaise movements are not necessarily responsible for primitive streak morphogenesis. Our data describe a previously undefined relationship between the large-scale cell flow and midline morphogenesis in gastrulation.
Taste shaped the use of botanical drugs
Authors: Leonti Marco , Baker Joanna , Staub Peter , Casu Laura , Hawkins Julie
Published: September 2023

The perception of taste (here defined as a combination of taste, odour and chemesthesis) enables animals to find high-value foods and avoid toxins. Humans have learned to use unpalatable and toxic substances as medicines, yet the importance of taste perception in this process is poorly understood. Here we generate tasting-panel data for botanical drugs and apply phylogenetic generalised linear mixed models to test whether taste intensity, complexity and particular tastes can predict ancient Graeco-Roman drug use. We found taste to be strongly predictive of therapeutic use: botanical drugs with high therapeutic versatility have simple yet intense tastes, and 21 of 22 tastes predicted at least one therapeutic use. In addition to the common notion of bitter tasting medicines, we also found starchy, musky, sweet, cooling, and soapy tasting drugs associated with versatility. In ancient Greece and Rome, illness was thought to arise from imbalance in bodily fluids or humours, yet our study suggests that uses of drugs were based on observed physiological effects that are often consistent with modern understanding of taste receptor pharmacology and medicine.
Human Lantern Ribozymes: Smallest Known Self-cleaving Ribozymes
Authors: Zhou Yaoqi , Zhang Zhe , Hong Xu , Xiong Peng , Wang Junfeng , Zhan Jian
Published: September 2023

Despite their importance in a wide range of living organisms, self-cleaving ribozymes in human genome are few and poorly studied. Here, we performed deep mutational scanning and covariance analysis of two previously proposed self-cleaving ribozymes (LINE-1 and OR4K15 ribozymes). We found that the functional regions for both ribozymes are made of two short segments, connected by a non-functional loop with a total of 46 and 47 contiguous nucleotides only. The discovery makes them the shortest known self-cleaving ribozymes. Moreover, the above functional regions of LINE-1 and OR4K15 ribozymes are circular permutated with two nearly identical catalytic internal loops, supported by two stems of different lengths. This new self-cleaving ribozyme family, named as lantern ribozyme for their shape, is similar to the catalytic core region of the twister sister ribozymes in term of sequence and secondary structure. However, the nucleotides at the cleavage sites have shown that mutational effects on lantern ribozymes are different from twister sister ribozymes. Lacking a stem loop for stabilizing the core active region and two mismatches in the internal loops may force lantern ribozymes to adopt a tertiary structure (and functional mechanisms) different from twister sister, requiring further studies. Nevertheless, the discovery of the lantern ribozymes reveals a new ribozyme family with the simplest and, perhaps, the most primitive structure needed for self-cleavage.
A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation
Authors: Ascenção Carolline , Sims Jennie R , Dziubek Alexis , Comstock William , Fogarty Elizabeth A , Badar Jumana , Freire Raimundo , Grimson Andrew , Weiss Robert S , Cohen Paula E , Smolka Marcus B
Published: September 2023

Meiotic sex chromosome inactivation (MSCI) is a critical feature of meiotic prophase I progression in males. While the ATR kinase and its activator TOPBP1 are key drivers of MSCI within the specialized sex body (SB) domain of the nucleus, how they promote silencing remains unclear given their multifaceted meiotic functions that also include DNA repair, chromosome synapsis, and SB formation. Here we report a novel mutant mouse harboring mutations in the TOPBP1-BRCT5 domain. Topbp1B5/B5 males are infertile, with impaired MSCI despite displaying grossly normal events of early prophase I, including synapsis and SB formation. Specific ATR-dependent events are disrupted, including phosphorylation and localization of the RNA:DNA helicase Senataxin. Topbp1B5/B5 spermatocytes initiate, but cannot maintain ongoing, MSCI. These findings reveal a non-canonical role for the ATR-TOPBP1 signaling axis in MSCI dynamics at advanced stages in pachynema and establish the first mouse mutant that separates ATR signaling and MSCI from SB formation.
Safflower (Carthamus tinctoriusL.) crop adaptation to residual moisture stress: conserved water use and canopy temperature modulation are better adaptive mechanisms
Authors: Manikanta Chennamsetti , Pasala Ratnakumar , Kaliamoorthy Sivasakthi , Basavaraj P. S. , Pandey Brij Bihari , Vadlamudi Dinesh Rahul , Nidamarty Mukta , Guhey Arti , Kadirvel Palchamy
Published: September 2023

Oilseeds with high productivity and tolerance to various environmental stresses are in high demand in the food and industrial sectors. Safflower, grown under residual moisture in the semi-arid tropics, is adapted to moisture stress at certain levels. However, a substantial reduction in soil moisture has a significant impact on its productivity. Therefore, assessing genetic variation for water use efficiency traits like transpiration efficiency (TE), water uptake, and canopy temperature depression (CTD) is essential for enhancing crop adaptation to drought. The response of safflower genotypes (n= 12) to progressive soil moisture depletion was studied in terms of water uptake, TE, and CTD under a series of pot and field experiments. The normalised transpiration rate (NTR) in relation to the fraction of transpirable soil water (FTSW) varied significantly among genotypes. The genotypes A-1, Bhima, GMU-2347, and CO-1 had higher NTR-FTSW threshold values of 0.79 (R2= 0.92), 0.74 (R2= 0.96), 0.71 (R2= 0.96), and 0.71 (R2= 0.91), respectively, whereas GMU-2644 had the lowest 0.38 (R2= 0.93). TE was high in genotype GMU-2347, indicating that it could produce maximum biomass per unit of water transpired. At both the vegetative and reproductive stages, significant positive relationships between TE, SPAD chlorophyll metre reading (SCMR) (p< 0.01) and CTD (p< 0.01) were observed under field conditions by linear regression. The genotypes with high FTSW-NTR thresholds, high SCMR, and low CTD may be useful clues in identifying a genotype’s ability to adapt to moisture stress. The findings showed that the safflower genotypes A-1, Bhima, GMU-2347, and CO-1 exhibited an early decline and regulated water uptake by conserving it for later growth stages under progressive soil water depletion.
The value of lymphocyte to monocyte ratio in the prognosis of head and neck squamous cell carcinoma: a meta-analysis
Authors: Wei Deyou , Liu Jiajia , Ma Jipeng
Published: September 2023

Objectives

Although lymphocyte-monocyte ratio (LMR) is a potential prognostic biomarker in many tumor indications, a doubt occurs around its association with head and neck squamous cell carcinoma (HNSCC). We aimed to evaluate the predictive value of LMR in patients with HNSCC.

Methods

We searched PubMed, Web of Science, EMBASE, and the Cochrane database from inception to May 8, 2023 for systematic review and meta-analysis on LMR and outcomes related to HNSCC development. STATA software was used to estimate the correlation between LMR and prognosis. The risk ratio (hazard ratio, HR) and 95% confidence interval l (CI) for overall survival (OS), disease-free survival (DFS), cancer-specific survival (CSS), and progression-free survival (PFS) were calculated, and the association between LMR and OS was further validated by subgroup analysis. The source of heterogeneity with the results of subgroup analysis was analyzed by meta-regression analysis. This meta-analysis was registered at PROSPERO (CRD42023418766).

Results

After a comprehensive exploration, the results of 16 selected articles containing 5,234 subjects were evaluated. A raised LMR was connected to improved OS (HR = 1.36% CI [1.14–1.62] P = 0.018), DFS (HR = 0.942, 95% CI [0.631–1.382], P = 0.02), and PFS (HR = 0.932, 95% CI [0.527–1.589], P < 0.022). Subgroup analysis indicated that patients with a low LMR level had a poor prognosis with a critical value of ≥4. The LMR was found to be prognostic for cases with an LMR of <4. The meta-regression analysis showed that the cut-off values and treatment methods were the primary sources of high heterogeneity in patients with HNSCC.

Conclusions

Our study suggested that an elevated LMR is a potential prognostic biomarker in patients with HNSCC and could be used to predict patient outcomes.
Caja de recuerdos. Tres miradas, en tres relatos a la participación de Chile en la Exposición universal de Londres 1851
Authors:   ,   Pontificia Universidad Católica de Chile. Facultad de Arquitectura, Diseño y Estudios Urbanos, Jara Farías Lya Raquel
Published: September 2023

Con las distintas participaciones en las exposiciones universales realizadas entre los siglos XIX y XXI, —aunque con asistencias interrumpidas—, Chile ha logrado construir una ‘mirada país’, que ha consolidado a lo largo de su historia, rescatando también con ello parte de una ‘mirada nacional’, propia de su realidad interna, y que en conjunto, guardan recuerdos de los hechos de nuestra historia nacional. Recordar relatos e historias de sus asistencias a estos eventos, nos lleva inevitablemente a buscar su participación en el primer evento, el más lejano, y el más desconocido, que tuvo lugar en la “Exposición universal de las industrias de todas las naciones”, realizada en Londres en 1851. A partir de los recuerdos encontrados, se analizará la verdadera participación de Chile en la Exposición, descubriendo las miradas y relatos que podrían desprenderse no sólo de este evento, sino que, además, podrían proyectar narraciones respecto al Chile de mediados del siglo XIX, —a su formación y a sus aspiraciones como país—, que reflejen su contexto y progreso. Su recopilación, le dará una nueva lectura y un relato a lo encontrado, junto con la narración de la primera participación de Chile en una exposición universal, entendida como la primera vez en que el país cruza sus fronteras, y comienza la construcción de su mirada país, con los distintos alcances que presentaba el año 1850 para nuestra nación.
Fortalecer la relación entre estudiantes y plan de lecturas domiciliarias a través de la mediación lectora y el vínculo emocional
Authors:   ,   Pontificia Universidad Católica de Chile. Facultad de Educación, Martin Pérez Melisa Alejandra
Published: September 2023

Este trabajo busca mejorar el vínculo con el texto literario leído en la escuela por parte de los y las estudiantes de una comunidad educativa de la Quinta Región. Se ha escogido para indagar al nivel de 2° Medio, a través de una evaluación al plan de lecturas domiciliarias del año 2022, cuyos resultados determinaron una relación negativa tanto con las obras como con el proceso de evaluación de las mismas. Frente a los resultados acogidos se presenta un plan de lecturas domiciliarias para el nivel de 3° Medio 2023, además de una secuencia didáctica que trabaja a partir de la mediación lectora desde la conexión emocional con el texto literario. Ambos insumos intentan responder a los requerimientos del estudiantado, presentados en la consulta preliminar. Posterior a la intervención, se han comparado las apreciaciones iniciales con las surgidas en la evaluación de las y los estudiantes de la implementación de la secuencia didáctica, presentándose una mejoría general en la relación texto-estudiante.
Risk premium structure of agricultural commodities
Authors:   ,   Pontificia Universidad Católica de Chile. Escuela de Ingeniería, Pérez Zañartu José Antonio
Published: September 2023

En esta tesis se desarrolla un modelo de precios dinámico, que utiliza tanto precios de contratos futuros como expectativas de precios entregadas por expertos para modelar el premio por riesgo del maíz, la soya y el trigo. La estructura de precios de los commodities agrícolas es determinada por sus ciclos de cosecha, existiendo similitudes y diferencias entre años de cosecha. Esto es considerado, dándole a cada año de cosecha independencia parcial con respecto a sus singularidades de respuesta a shocks de oferta y demanda, de tal manera de capturar los patrones estacionales variables en el tiempo, característicos de los commodities agrícolas. Se implementa la versión del modelo con cinco variables de estado estocásticas, donde dos de ellas se activan dependiendo de la cantidad de años de cosecha al vencimiento. Se obtienen estimaciones de los premios por riesgo, que dependen del horizonte y número de años de cosecha al vencimiento. El modelo muestra resultados diferentes para el maíz, la soya y el trigo de invierno.
Cultivation of Hybrids Mustard (Brassica juncea L.) in the Pedo- Climatic Conditions of paryagraj Sangam Region (U.P), India
Authors: Ranjan Shree Ram , Singh Vikram , Kumar Sujit
Published: September 2023

The field experiment was carried out at the Crop Research Farm, Department of Agronomy, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj during Rabi season 2021-22 on Mustard crop. The experiment was performed in randomized block design with ten treatments and three replication. The soil of experimental plot was sandy loam in texture, nearly neutral in soil reaction (pH 7.1), low in organic carbon (0.36%), available N (171.48 kg/ha), available P (15.2 kg/ha) and available K (232.5 kg/ha). The maximum plant height (171.76 cm), primary branches (6.5/plant), secondary branches (16.20/plant), plant dry weight (43.43 g/plant) at 100 DAS in hybrid ADV 4029 was recorded. Maximum Crop growth rate (CGR) recorded at 40-60DAS (20.32 g/m2 /day), number of siliqua/plant (457.27), number of seeds/siliqua (13.55), test weight (4.73 g) and seed yield (2.51 t/ha) were observed in hybrid ADV 4029. In terms of economics, highest gross returns (Rs 136660.90/ha), net returns (Rs 87347.93/ha) and B:C ratio (1.77) were observed in hybrid ADV 4029.
Nasopharyngeal Carcinoma Mimicking Sinonasal Undifferentiated Carcinoma
Authors: Yuszaini A. B.  , Musa Zalilah , Hidayah Nur
Published: September 2023

Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells that covers the surface and lining of the nasopharynx. It is divided into keratinizing squamous cell carcinoma, and non-keratinizing carcinoma, which can be further divided into differentiated and undifferentiated subtypes. Symptoms of NPC can be obscure due to its anatomic location. On the other hand, sinonasal undifferentiated carcinoma defined as a highly aggressive and clinicopathologically distinctive carcinoma of uncertain histogenesis that typically presents with locally extensive disease. The present report is a case of 66-year-old malay woman with underlying hypertension, hyperlipidemia and ischemic heart disease presented with swelling over the left upper palate for 5 months associated with the nasal symptoms. Cranial nerves were intact. Nasal endoscopy of the left nose revealed a mass occupying the left nasal cavity with histopathology of sinonasal undifferentiated carcinoma. However, CT scan result showed huge left nasopharyngeal carcinoma with local invasion and intracranial extension.
Current Status of RV Reducer Development in China and Abroad
Authors: Han Linshan , Zhang Yushuai , Wang Yingjia , Xu Weihao
Published: September 2023

RV reducer has a wide range of applications in China due to a series of advantages such as high precision (backlash less than 1 Angle minute), high rigidity, high durability, high output density (strong torque & compact), wide reduction ratio range and low vibration. Due to the large gap between domestic RV reducer and foreign brands, this is mainly reflected in the low level of research and low investment due to low profitability, the domestic RV reducer market relies heavily on imports at present. By reviewing the development status of RV reducer at home and abroad, this paper points out the restrictive factors in the development of domestic RV reducer, the number of patents filed as the main measure for assessing the level of research in China and abroad, and puts forward suggestions and directions for the development of domestic RV reducer, providing reference for the next development of domestic RV reducer.
Understanding the Effects of Three Carbohydrate Feeds on the Health of Apis mellifera by Transcriptome Analysis
Authors: Xiong Ting , Xie Daohao , Li Zhitao , Yang Zhiyue , Dong Kun , Yang Minghua , Li Yahui
Published: January 2025

At present, there is no clear consensus on the impact of carbohydrate feeds on bee colony health, and comprehensive research and evaluation in this context is lacking. To comprehensively and objectively examine the health status of honeybees after consuming those carbohydrates from multiple perspectives, experimental techniques, including high‐throughput sequencing of the transcriptome, proboscis extension reflex (PER), and measuring bee growth parameters were employed. This study showed that compared with honey, feeding high fructose syrup (HFS) resulted in a decrease in the survival rate and body weight of bees, while sucrose decreased the learning and memory ability of bees. After feeding on honey, the main antimicrobial peptides including abaecin, apidaecin1, hymenoptin, and defensin in bees, are all upregulated in expression. The 14 DEGs significantly enriched in the axonal regeneration pathway were all downregulated in the sucrose group and HFS group. This study demonstrated that the expression of multiple genes involved in oxidative phosphorylation was downregulated in bees fed with HFS, moreover, HFS also affected the biosynthesis of unsaturated fatty acids. These effects may lead to energy and metabolic disorders (including fatty acids), thereby inhibiting the growth and development of bees. Sucrose can decrease the learning and memory ability of bees, which may be due to the downregulation of genes related to learning and memory in the axonal regeneration pathway. Honey can upregulate antimicrobial peptides and other immune‐related proteins, activating the bee's immune system and boosting bees' immunity to pathogens.
Curcumin attenuates ulcerative colitis via regulation of Sphingosine kinases 1/NF‐κB signaling pathway
Authors: Zhang Xiuli , Zhang Hao , Wang Jingting , Chen Yangyi , Lin Jiumao , Wang Qingshui , Wu Cheng , Chen Hui , Lin Yao
Published: January 2025

Curcumin, a compound from Curcuma longa L., has significant anti‐inflammatory properties. However, the mechanisms underlying its anti‐inflammatory activity in dextran sodium sulfate (DSS)‐induced ulcerative colitis (UC) remain inadequately understood. This study aimed to further elucidate the molecular mechanisms of curcumin DSS‐induced UC mice. Our data showed that curcumin alleviated DSS‐induced colitis by reducing intestinal damage and inflammation, increasing goblet cells in colon tissues. Enzyme‐linked immunosorbent assay revealed that curcumin reduced the expression of inflammatory cytokines (tumor necrosis factor‐alpha, interleukin‐1β, and interleukin‐8) in serum and myeloperoxidase in colon tissues. A comprehensive analysis integrating network pharmacology and RNA sequencing (RNA‐seq) revealed significant enrichment of the nuclear factor kappa B (NF‐κB) signaling pathways. Notably, RNA‐seq analysis demonstrated that curcumin significantly downregulated the mRNA expression of sphingosine kinase 1 (SphK1). Furthermore, molecular docking analysis showed that curcumin can bind to SphK1 and NF‐κB. Additionally, curcumin was found to inhibit the activation of the SphK1/NF‐κB signaling pathway in DSS‐induced UC colon tissue. This study addresses pharmacologic and mechanistic perspectives of curcumin that ameliorates DSS‐induced UC and inflammatory response.
Uncovering the Catalysts of Sustainable Business Performance: Digital Orientation, Entrepreneurial Competency, and Strategic Change
Authors: Baawain Ali Mohsin , Laachach Abderrahim , Jaboob Ali Said , Kankaew Kannapat
Published: January 2025

This research investigates the complex relationships between digital orientation, entrepreneurial competency, and strategic change, and their impact on sustainable business performance. It also explores how sustainable competitive advantage and flexible resources moderate the link between strategic change and sustainable performance outcomes in dynamic business environments. The authors collected survey data from 349 small and medium‐sized enterprises (SMEs) to test the proposed model. They then used partial least squares structural equation modelling (PLS‐SEM) with SmartPLS 4 software to analyze the relationships between the variables. The findings reveal that digital orientation strongly drives strategic change, which in turn strongly enhances sustainable business performance. Digital orientation also directly leads to sustainable performance. Strategic change mediates the relationship between digital orientation and sustainable performance, while entrepreneurial competency partially mediates the effects of digital orientation. Competitive advantage and flexible resources moderately strengthen the link between strategic change and sustainable performance. This study provides novel insights into the complex interplay between digital orientation, entrepreneurial competency, and strategic change, and how these factors jointly contribute to sustainable business performance. The findings also uncover the moderating roles of competitive advantage and flexible resources, offering practical guidance for managers seeking to enhance long‐term organizational success in dynamic environments.
Perceived Influences of Mentoring on Mentors' Social Well‐Being: Social Self‐Efficacy and Civic Engagement as Mediators of Long‐Term Associations
Authors: Marino Claudia , Christens Brian D. , Lenzi Michela , Galeotti Tommaso , Gaboardi Marta , Tubertini Elena , Canale Natale , Vieno Alessio , Bonichini Sabrina , Bergamin Marisa , Cavell Timothy A. , Santinello Massimo
Published: January 2025

In literature, there is a paucity of research examining the outcomes of mentoring programs for mentors. The goal of this study was to enhance understanding of the long‐term impact of mentoring experiences on mentors' social well‐being by testing a model in which the perceived influence of mentoring on work choices, volunteer choices and level of active participation in the community are associated with social self‐efficacy, civic engagement (attitudes and behaviours), and, in turn, with social wellbeing. This study surveyed cohorts of former mentors (N = 203; 83% female) who took part in the mentoring and service‐learning program called Mentor UP in Italy. Results showed the mediating role of social self‐efficacy between the influence of mentoring on active participation in the community and social well‐being (β = 0.05, p = 0.042) and between the same perceived influence of mentoring and civic engagement behaviour (β = 0.08, p = 0.009). Moreover, the influence of mentoring and social well‐being was fully mediated by participants' current levels of civic engagement (attitudes and behaviours). These findings suggest that mentoring experiences can sustain college students' interpersonal effectiveness, civic responsibility and social well‐being in long‐lasting ways. Mentoring programs should therefore promote and measure these outcomes.
Elucidating the Biological Potential and DNA Protective Activities of Astragalus tokatensis Fisch: Gas Chromatography‐Mass Spectrometry and Liquid Chromatography‐High Resolution Mass Spectrometry‐Based Characterization and Molecular Docking Studies
Authors: Selvi Bedrettin , Zanbak Nahide Kübra
Published: January 2025

Astragalus tokatensis Fisch. is a local endemic species, and no studies have been conducted on this species. Hexane, dichloromethane, methanol, and water extracts were obtained from the roots, leaves, and flowers of A. tokatensis. The phytochemical analyses of hexane and methanol extracts were identified and characterized using gas chromatography‐mass spectrometry (GC‐MS) and liquid chromatography‐high resolution mass spectrometry (LC‐HRMS), respectively, for the first time. A total of 11 fatty acids and eight flavonoid derivatives were detected by GC‐MS and LC‐HRMS analyses, respectively. The total antioxidant level (TAL) and total oxidant level (TOL) of the extracts were investigated. TAL and TOL values were expressed as mM Trolox equiv/L and µM H2O2 equiv/L, respectively. İt was determined that all extracts showed high antioxidant activity according to reference value >2.0, and the highest antioxidant activity was found in the water extract of the leaf with 4.292 mM Trolox equiv/L. In addition, the α‐amylase enzyme activity of all the extracts was examined, and it was found that the extracts had no significant effect on α‐amylase activity. In addition, the DNA‐protective activities of the leaf and flower extracts were determined by gel electrophoresis, and it was observed that all flower extracts had high DNA‐protective activity. Moreover, Docking assays showed that the limited interactions of sinapinic acid and salicylic acid, the most abundant in the methanol extracts, with α‐amylase, supported the weak inhibitory effects observed experimentally in the methanol extracts.
Design and Room‐Temperature Synthesis of a Multipurpose and Sustainable Heterogeneous Catalyst Decorated with Lewis Acidic Metal Sites and Dangling Pyridyl Groups
Authors: Chanda Alokananda , Mandal Sanjay K.
Published: January 2025

In this work, we report a 2D metal‐organic framework with dangling pyridine groups, {[Cd2(4‐tpom)2(oxdz)2(H2O)2]·4H2O}n (1), has been synthesized using a flexible N‐donor linker, 4‐tpom (tetrakis(4‐pyridyloxymethylene)methane), and a bent dicarboxylate, oxdz2−(4,4′‐(1,3,4‐oxadiazole‐2,5‐diyl)‐dibenzoate), to demonstrate its multipurpose as a bifunctional heterogeneous catalyst. Its thermal (up to 332 °C) and chemical stability in water and methanol and at different pH levels (5, 7.4, 9) provides sustainability for any application. Its structural features and properties are well established by elemental analysis, powder X‐ray diffraction (PXRD), various spectroscopic/microscopic techniques, and geometry optimization. With unsaturated metal centers as the Lewis acidic sites and uncoordinated nitrogen/oxygen atoms as the Lewis/Bronsted basic sites, a very low catalyst loading (1.5 mol%) of activated 1 is found to be sufficient to catalyze two important C─C bond‐forming reactions at room temperature: a) the cyanosilylation reaction converting benzaldehyde to trimethyl silyl ether (100% in 5 h) under solvent‐free conditions, and b) the Knoevenagel‐intramolecular cyclization reaction for converting salicylaldehyde to coumarin‐3‐carboxylic acid in methanol (99% in 1 h). Notably, this is the first time the same catalyst has been utilized for these two reactions, demonstrating its multipurpose nature. Furthermore, the spent catalyst is recyclable for multiple cycles, maintaining its structural integrity established via FTIR spectroscopy and PXRD.
Measuring the size of oil droplets in a flow cytometer using Mie resonances: A possible size calibration ladder for 0.5–6 μm
Authors: Cavicchi Richard E. , Ripple Dean C. , Welsh Joshua A. , Izac Jerilyn R. , Peterson Alexander W. , Goldfain Aaron M. , Vreeland Wyatt N.
Published: January 2025

An emulsion of silicone oil droplets in aqueous buffer produces a distinctive series of peaks or resonances in the side scatter histogram in a flow cytometer. As many as 12 peaks are observed in the violet‐side scatter channel at 405 nm, with half that number observed in the blue side scatter channel at 488 nm. Using the index of refraction of the oil and buffer, the wavelength of light, and the collection angle and gain of the instrument, we assign the peaks to specific diameters at which Mie resonances occur. With the close match for the index of refraction of silicone oil (n = 1.417 at 405 nm) to biological materials, these resonances could form the basis of a finely spaced size calibration ladder in the range 0.5–6 μm for estimating the size of biological particles in a flow cytometer. Resonances were also observed using mineral oil (n = 1.483 at 405 nm) suggesting that investigating and modeling resonances for emulsion systems may be useful for understanding these systems.
Microsatellite and Mitochondrial COI Provide Novel Insights Into the Population Genetic Structure of White Prunicola Scale (Pseudaulacaspis prunicola) in China
Authors: Niu Minmin , Fu Dengen , Wang Haoyang , Liu Yun , Du Xuanxing , Zhao Qing , Wei Jiufeng
Published: January 2025

The white prunicola scale Pseudaulacaspis prunicola (Maskell) is an important pest of fruit and ornamental plants, characterised by its wide distribution, broad host range and distinct biological traits. In this study, a comprehensive population genetic analysis of P. prunicola in China was conducted, focusing on genetic diversity, genetic structure, relationships among geographical populations, and population dynamics. Microsatellite molecular and mitochondrial COI markers were used to examine the genetic diversity and structure of 19 P. prunicola populations across 10 provinces in China. The results revealed low genetic diversity and limited gene flow among populations. A clear geographic genetic structure was identified, with the 19 populations being, divided into four distinct groups, showing a pronounced north–south distribution pattern. Significant genetic differentiation was observed between these groups, with minimal gene exchange. COI‐based diversity analyses produced results similar to those obtained from the microsatellite markers. These findings provide valuable insights into the distribution and spread of P. prunicola in China and may help inform the development of effective and targeted pest control strategies.