bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Utility of a Reaction-Time Attention Task in the Evaluation of Cognitive Impairment in Elderly with High Educational Disparity
Authors: Schmidt Sergio L. , Boechat Yolanda Eliza Moreira , Schmidt Guilherme J. , Nicaretta Denise , van Duinkerken Eelco , Schmidt Juliana J.
Published: April 2021

Background: The Clinical Dementia Rating (CDR) scale is commonly used to stage cognitive impairment, despite having educational limitations. In elderly with low education, a previous study has shown that intraindividual variability of reaction time (CV) and commission errors (CE), measured using a culture-free Go/No-Go task, can reliably distinguish early Alzheimer’s disease (AD) from mild cognitive impairment (MCI) and healthy controls. Objective: We aimed to extend the clinical utility of this culture-free Go/No-Go task in a sample with high educational disparity. Methods: One hundred and ten participants with a wide range of years of formal education (0–14 years) were randomly selected from a geriatric unit and divided based on their CDR scores into cognitively unimpaired (CDR = 0), MCI (CDR = 0.5), and early AD (CDR = 1). All underwent a 90-s reaction-time test that measured the variables previously found to predict CDR in low educated elderly. Here we added years of formal education (educational level) to the model. Multivariate analyses compared differences in group means using educational level as confounding factor. A confirmatory discriminant analyses was performed, to assess if CDR scores could be predicted by the two Go/No-Go variables in a sample with high educational disparity. Results: Over all three groups, differences in both CE and CV reached statistical significance (p < 0.05). The discriminant analysis demonstrated that CV and CE discriminated cognitively impaired from cognitively normal elderly. These results remained similar when discriminating MCI from cognitively unimpaired elderly. Conclusion: The Go/No-Go task reliably discriminates elderly with MCI from elderly without cognitive impairment independent of educational disparity.
A quaternion-group knowledge graph embedding model
Authors: Chen Heng , Li Guanyu , Sun Yunhao , Jiang Wei
Published: April 2021

Capturing the composite embedding representation of a multi-hop relation path is an extremely vital task in knowledge graph completion. Recently, rotation-based relation embedding models have been widely studied to embed composite relations into complex vector space. However, these models make some over-simplified assumptions on the composite relations, resulting the relations to be commutative. To tackle this problem, this paper proposes a novel knowledge graph embedding model, named QuatGE, which can provide sufficient modeling capabilities for complex composite relations. In particular, our method models each relation as a rotation operator in quaternion group-based space. The advantages of our model are twofold: (1) Since the quaternion group is a non-commutative group (i.e., non-Abelian group), the corresponding rotation matrices of composite relations can be non-commutative; (2) The model has a more expressive setting with stronger modeling capabilities, which is flexible to model and infer the complete relation patterns, including: symmetry/anti-symmetry, inversion and commutative/non-commutative composition. Experimental results on four benchmark datasets show that the proposed method outperforms the existing state-of-the-art models for link prediction, especially on composite relations.
Oxaliplatin Neuropathy: Predictive Values of Skin Biopsy, QST and Nerve Conduction
Authors: Krøigård Thomas , Svendsen Toke K. , Wirenfeldt Martin , Schrøder Henrik D. , Qvortrup Camilla , Pfeiffer Per , Gaist David , Sindrup Søren H.
Published: April 2021

Background:

Oxaliplatin-induced peripheral neuropathy negatively affects the quality of life for patients with gastrointestinal cancers and may cause neuropathic pain. Measures of peripheral nerve structure or function, such as intraepidermal nerve fiber density (IENFD) during treatment could reduce neuropathy severity through individualized dose reduction.

Objective:

The aim was to evaluate the predictive values of IENFD, quantitative sensory testing (QST), and nerve conduction studies (NCS) for significant neuropathy and neuropathic pain.

Methods:

Fifty-five patients were examined prospectively before, during, and six months following treatment using skin biopsies, QST and NCS. Clinically significant neuropathy six months after treatment was defined as reduced Total Neuropathy Score of more than five and neuropathic pain was assessed according to International Association for the Study of Pain criteria.

Results:

Thirty patients had a clinically significant neuropathy, and 14 had neuropathic pain. Vibration detection threshold (VDT) before treatment was correlated with clinically significant neuropathy six months after treatment (OR 0.54, p = 0.01) and reductions in cold detection threshold (CDT) after 25% of treatment (OR 1.38, p = 0.04) and heat pain threshold (HPT) after 50% of treatment (OR 1.91, p = 0.03) with neuropathic pain. Cut off values of 5 for baseline VDT and changes of more than –0.05 °C and –0.85 °C in CDT and HPT were estimated. Sensitivity and specificity was low to moderate. There was no correlation between changes in IENFD or NCS and significant neuropathy or neuropathic pain.

Conclusions:

Vibration detection thresholds and thermal detection thresholds may be useful for prediction of clinically significant and painful neuropathy, respectively. However, low to moderate sensitivity and specificity may limit the predictive value in clinical practice.
Smartphones for Remote Symptom Monitoring of Parkinson’s Disease
Authors: Little Max A.
Published: April 2021

Parkinson’s disease is a complex and heterogeneous condition, and there are many gaps in the medical community’s scientific and practical understanding of the disease. Closing these gaps relies on objective data about symptoms and signs, collected over long durations. Smartphones contain sensor devices which can be used to remotely capture behavioral signals. From these signals, computational algorithms can distill metrics of symptom severity and progression. This brief review introduces the main concepts of the discipline, addressing the experimental, hardware and software logistics, and computational analysis. The article finishes with an exploration of future prospects for the technology.
Bringing Advanced Therapy Medicinal Products (ATMPs) for Parkinson’s Disease to the Clinic: The Investigator’s Perspective
Authors: Barker Roger A. , Cutting Emma V. , Daft Danielle M.
Published: April 2021

There is much excitement around the use of advanced therapy medicinal products (ATMPs), including cell and gene treatments, in Parkinson’s disease (PD). However, taking an ATMP to clinical trials in patients with PD is complex. As such it is important from an investigator’s perspective that they ask themselves two key questions before embarking on such work: firstly, why are you doing it, and, secondly, do you understand what is needed to conduct a clinical trial with that product. In this article, we briefly discuss these two questions.
Imaging pediatric acute head trauma using 100-kVp low dose CT with adaptive statistical iterative reconstruction (ASIR-V) in single rotation on a 16 cm wide-detector CT
Authors: Zhu Yanan , Pi Zhian , Zhou Heping , Li Zhengjun , Lei Faqing , Hui Jianjun , Zhang Ximeng , Xie Juanping , Liang Yukun
Published: April 2021

OBJECTIVE:

To demonstrate the ability of achieving low dose and high-quality head CT images for children with acute head trauma using 100 kVp and adaptive statistical iterative reconstruction (ASIR-V) algorithm in single rotation on a 16 cm wide-detector system.

MATERIALS AND METHODS:

We retrospectively analyzed the CT dose index (CTDI) and image quality of 104 children aged 0–6 years with acute head trauma (1 hour –3 days) in two groups: Group 1( n = 50) on a 256-row CT with single rotation at a reduced-dose of 100 kVp/240 mA and reconstructed using ASIR-V at 70%level; Group 2( n = 54) on a 64-row CT with multiple rotations at a standard dose of 120 kVp/ 180mA and reconstructed using a conventional filtered back-projection (FBP). Both groups used the 0.5 s/r axial scan mode. CT dose index (CTDI) and quantitative image quality measurements were compared using the Student t test; qualitative image quality comparison was carried out using Mann-Whitney rank test and the inter-reviewer agreement was evaluated using Kappa test.

RESULTS:

The exposure time was 0.5 s for Group 1 and 3.27±0.29 s for Group 2. The CTDI in Group 1 was 9.74±0.86mGy, 36.38%lower than the 15.31mGy in Group 2 ( p < 0.001). Group 1 and Group 2 had similar artifact index (2.06±1.06 vs. 2.37±1.18) in the cerebellar hemispheres, and similar contrast-to-noise ratio (2.32±0.83 vs. 1.69±0.68), (1.47±0.72 vs. 1.10±0.43) respectively for cerebellum and thalamus ( p > 0.05). Image quality was acceptable for diagnosis, and motion artifacts were reduced in Group 1 ( p < 0.001).

CONCLUSION:

Single rotation CT with 100 kVp and 70%ASIR-V on 16 cm wide-detector CT reduces radiation dose and motion artifacts for children with acute head trauma without compromising diagnostic quality as compared with standard dose protocol. Thus, it provides a novel imaging method in management of pediatric acute head trauma.
Spatial variability of SARS-CoV-2 infection in the Silesian voivodeship, Poland
Authors: Kowalska M , Hudzik G , Wodzisławska-Czapla D , Kaleta A , Zejda J E
Published: April 2021

ABSTRACT
INTRODUCTION. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) and related to infection COVID-19 (coronavirus disease 2019) remain a new and global challenge for public health. Due to the location, specifics of employment, and the high density of population in the Silesia voivodeship it is appropriate to study the available epidemiological data in a region with a potentially higher risk of infection.
MATERIALS AND METHODS. In the descriptive model of the study, data on the number of infected, hospitalized, and dead people due to SARS-CoV-2 infection were analyzed. The source of information was daily reports conducted by the Provincial Sanitary and Epidemiological Station in Katowice, in the period from March 5 to August 18, 2020.
RESULTS. Results of antigenic molecular tests for SARS-CoV-2 infection in the Silesian voivodeship indicate that in the first half of 2020, the infection rate was approximately 5% and the symptomatic form of the disease was approximately 20%.
CONCLUSIONS. The analysis of the frequency of infection and mortality in the poviats reveals a large variation in the occurrence of both phenomena, but the explanation of this difference is not possible due to the descriptive nature of the analysis and the secondary form of epidemiological data.

STRESZCZENIE
WSTĘP. Zakażenie wirusem SARS-CoV-2 i związana z nim choroba COVID-19 stanowią nowe, globalne wyzwanie dla zdrowia publicznego. Z uwagi na lokalizację i specyfikę zatrudnienia oraz duże zagęszczenie liczby mieszkańców w województwie śląskim, celowe jest badanie dostępnych danych epidemiologicznych w regionie o potencjalnie większym ryzyku zakażenia.
MATERIAŁ I METODY. W modelu badania opisowego przeanalizowano dane o liczbie zakażonych, liczbie zgonów i osób hospitalizowanych w związku z zakażeniem SARS-CoV-2. Źródłem informacji były dzienne raporty prowadzone przez Wojewódzką Stację Sanitarno-Epidemiologiczną w Katowicach, w okresie od 05 marca do 18 sierpnia 2020 roku.
WYNIKI. Wyniki antygenowych badań molekularnych w kierunku zakażenia wirusem SARS-CoV-2 w województwie śląskim wskazują, że w pierwszym półroczu 2020 roku częstość zakażeń kształtowała się na poziomie około 5%, a częstość objawowej postaci choroby na poziomie około 20%.
WNIOSKI. Analiza częstości zakażeń oraz śmiertelności w układzie terytorialnym województwa (powiaty) ujawnia duże zróżnicowanie występowania obu zjawisk, przy czym wyjaśnienie tego zróżnicowania nie jest możliwe ze względu na opisowy charakter analizy oraz tzw. wtórną postać danych epidemiologicznych.
Mitigasi Kegagalan Guna Mewujudkan Keberlanjutan E-Government
Authors: Puspitasari Dian Ayu , Kurniawan Teguh
Published: April 2021

This study will discuss the government's effort to mitigate the failure in realizing e-government sustainability. E-government sustainability is essential to be reviewed to ensure the system's long-term provision of benefits to the public. This study used qualitative research methods through literature studies. The result of this study showed that the e-government sustainability discusses the length of implementation and the outcomes of e-government to stakeholders. The failure of e-government is still a challenge in realizing e-government sustainability by the government. For this reason, the government needs to mitigate the risk of failure. Some actions that can be taken by the government to realize e-government sustainability include: 1. Ensure that e-government is future-oriented; 2. Analyze the factors that will support the success and sustainability of e-government from the beginning and incorporate them into planning; 3. Ensure the availability of resources and support from stakeholders; 4. Evaluate by looking at the reality that is currently happening; and 5. Develop e-government according to public needs.Studi ini akan menguraikan upaya pemerintah dalam memitigasi kegagalan guna mewujudkan keberlanjutan e-government. Keberlanjutan e-government merupakan suatu hal yang penting untuk dikaji guna memastikan pemberian manfaat oleh sistem dalam jangka waktu yang panjang kepada publik. Pendekatan yang digunakan dalam studi adalah kualitatif dengan metode pengumpulan data melalui kajian pustaka. Hasil studi menunjukkan bahwa keberlanjutan e-government tidak hanya membahas mengenai waktu implementasi saja, tetapi juga dampak dari e-government kepada stakeholder. Kegagalan e-government masih menjadi tantangan dalam mewujudkan keberlanjutan e-government oleh pemerintah. Untuk itu, pemerintah perlu untuk melakukan mitigasi munculnya risiko kegagalan. Beberapa upaya yang dapat dilakukan oleh pemerintah guna mewujudkan keberlanjutan e-government, antara lain: 1. Memastikan bahwa e-government berorientasi kedepan; 2. Menganalisis faktor-faktor yang akan mendukung kesuksesan dan keberlanjutan e-government sedari awal dan memasukkan hal-hal tersebut dalam perencanaan; 3. Memastikan adanya ketersediaan sumber daya dan dukungan dari stakeholder; 4. Melakukan evaluasi dengan melihat realitas yang saat ini sedang terjadi; serta 5. Mengembangkan e-government sesuai dengan kebutuhan publik.
Happy Elderly Through Elderly School: Collaboration in Empowering Elderly in Bandung City
Authors: Artisa Rike Anggun , Kirana Cintantya Andhita Dara
Published: April 2021

The development of a paradigm in which the government no longer the only actor in charge of public affairs opens greater opportunities for the elderly to get attention. The elderly become a group with vulnerable conditions, from physical, social, mental, and spiritual aspects. The elderly school was formed through collaboration as a form of caring for the elderly in Bandung City. The elderly school is intended to improve the knowledge and behavior of the elderly towards health, increase the index of happiness, improve the quality of life and productivity, and increase independence from physical, psychological, social, and spiritual aspects. The purpose of this study is to identify and analyze the factors that drive collaboration, the collaborative process, and the benefits of collaboration. The research method used is a qualitative research method with a descriptive approach. The results show that the collaboration in the elderly school program is driven by the same goals and interests related to empowering the elderly, having appropriate resources with their fields and functions, and getting benefits from their involvement. Then, the collaborative process begins with a dialogue to build trust among stakeholders to build commitment to this program. Collaboration in senior schools is not only beneficial for the elderly but also for the actors involved.
A case report: Early findings of distal vessel occlusion pre and post-thrombolysis using three-dimensional black blood vessel wall imaging in acute stroke.
Authors: Kamis Mohd Fandi Al Khafiz , Peck Kee Chia , Mohd Yaakob Mohd Naim , Abdul Rahim Ezamin , Muda Ahmad Sobri , Mohd Sabri Mohd Naqib , Abd Ghani Fatimatulzahra
Published: April 2021

Distal vessel occlusion of an eloquent area in acute stroke may lead to significant disability. Advances in magnetic resonance imaging enable direct visualization of thrombus within the small distal intracranial artery. The evolution of medical devices for mechanical thrombectomy has allowed the smaller distal vessels to be treated. It may change the approach to how we treat distal vessel occlusion in the future. This case highlights the value of three-dimensional black blood vessel wall imaging assessing distal vessel occlusion and respond towards reperfusion therapy.
Hypocrisy and Moral Justification: Do Consequences and Reasons Make a Difference?
Authors: Vijayasingam Vinoja , Hussain Zakia , Bramesfeld Kosha
Published: April 2021

In this experiment, we examined if an act of hypocrisy would be judged as more morally justified if it (a) led to a lenient consequence versus a harsh consequence for another person and (b) was done for an other-focused versus self-focused reason. The experiment was implemented via an online study that used a 3 x 3 between-groups factorial design that manipulated the consequences of, and reasons for, an act of hypocrisy. We found that hypocrisy that led to a harsh consequence for another person was viewed as less morally justified than the same harsh act that occurred in the absence of hypocrisy, p < 0.001, Cohen’s d = 0.56, or when hypocrisy led to a lenient consequence for another person, p < 0.001, Cohen’s d = -.87. The reason given for the hypocritical act did not impact perceptions of moral justification, p = .67, η2 < .01, nor was there an interaction between consequences and reason, p = .49, η2 = .03. These results support the hypothesis that hypocrisy was judged negatively because it led to harsh consequences for others; however, our research leaves open the question of whether hypocrisy can be explained away with a compelling reason or not.
Are you still watching?
Authors: Chandran Ilakkiah
Published: April 2021

Netflix and other streaming services have become extremely popular over the last few years. Although streaming through online services is often thought of as self-care and relaxation, binge-watching has become a common watching pattern. This opinion-editorial will report upon the ways binge-watching leads to daily challenges and long-term consequences when it comes to our mental and physical health, socialization and ability to reach goals. Furthermore, it will discuss important implementations that will reduce the negative effects associated with binge-watching to aid in the pursuit of self-control.
Estrategias de ordenamiento territorial sostenible para el cantón Gualaceo
Authors: Sarango Simbaña Sandra Marisol , Ávila Calle Marco Benigno , Castillo Ortega Yonimiler
Published: April 2021

En el Ecuador desde el año 2010 se ha venido dando experiencias planificadoras a través de los planes de desarrollo y ordenamiento territorial a cargo de los Gobiernos Autónomos Descentralizados en el caso del cantón Gualaceo ubicado en la parte oriental de la provincia del Azuay. Objetivo. fortalecer e implementar estrategias para un ordenamiento territorial que garantice su sostenibilidad. Metodologìa. Una vez revisado el marco teórico de la planificación y ordenamiento territorial es necesario reflexionar su cumplimiento con la evaluación del PDOT en un período determinado 2015-2019, en base a una revisión documental, encuestas y entrevistas de la percepción de sus autoridades y técnicos de planificación. Resultados. Del análisis de la investigación, evidenciando un bajo grado de cumplimiento en cada una de las estrategias planteadas en la fase de la propuesta referente al modelo territorial y el modelo de gestión, lo que permite establecer una propuesta de la estrategia ambiental y el fortalecimiento de las estrategias planteadas en sus planes. Conclusión. Para garantizar un ordenamiento territorial sostenible comprendiendo en la visión planteada del cantón con liderazgo gubernamental conscientes del conocimiento de los potenciales y debilidades de su territorio.
Modelo de optimización de la cadena de distribución de la agricultura familiar campesina en las parroquias Quingeo y Santa Ana del Cantón Cuenca
Authors: Piedra Rivas María Cecilia , Banegas Campoverde Christian Mauricio , Castillo Ortega Yonimiler
Published: April 2021

Introducción. La comercialización efectiva, así como la entrega directa de productos hacia el consumidor, por parte de familias de agricultores, requiere de un conocimiento eficaz de la dinámica de las cadenas de distribución. Tradicionalmente esto se obtiene mediante la mejora de las cadenas de valor y el acceso a los mercados, sin embargo, existen otros factores críticos que están involucrados en el proceso y que además pueden interactuar de manera distinta en cada comunidad.  Objetivo Establecer un modelo de optimización de la cadena de distribución de la agricultura familiar campesina de las parroquias Quingeo y Santa Ana. Metodología se basó en la elaboración de encuestas para diagnosticar los principales obstáculos a lo largo de las rutas de la agricultura familiar campesina.  Resultados Este estudio muestra que los problemas más graves que tienen los agricultores son la falta de mercado, transporte, precios injustos y difusión. En segundo lugar, aparecen también como problemas importantes el fortalecimiento organizativo y asistencia técnica.  Conclusión. Se concluyó que el estudio permitió definir un modelo de optimización de la cadena de distribución que visualiza la complejidad del proceso.
Síntesis del N-decil-4-((3-formil-4-hidroxifenoxi) metil) benzamida por reacción de ácido 4-bromometilbenzoico, decilamina y 2,5-dihidroxibenzaldehído.
Authors: Lozano Mera Bryan David , Carrera Almendáriz Luis Santiago , Flores Huilcapi Ana Gabriela
Published: April 2021

Introducción: Las vacunas actuales basadas en subunidades proteicas requieren de inmunoadyuvantes para llegar a una eficiencia óptima, para ello se han sintetizado compuestos que pueden lograr esta capacidad sin afectar al ser humano. Este tipo de vacunas ofrecen ventajas significativas frente a las vacunas tradicionales que emplean agentes patógenos completos. Objetivo: Desarrollar una ruta sintética para la obtención de un compuesto orgánico, que posea la capacidad inmunopotenciadora para el sistema humano. Metodología: La investigación es de tipo experimental en condiciones normales de laboratorio. Se diseña una ruta sintética en dos etapas, la primera tiene la finalidad de dotarle solubilidad en medio apolar a la molécula resultante, mediante la formación de una amida por parte de la reacción entre decilamina con ácido 4-bromometilbenzoico, permitiendo que la molécula atraviese la membrana celular, a diferencia de la segunda etapa que es obtener la estructura responsable de la capacidad inmunopotenciadora. Se emplean sistemas de aislamientos mediante cromatografía de capa fina para definir los sistemas de solventes que se utilizaron en la cromatografía líquida y guiadores de reacción para facilitar la formación de los grupos funcionales específicos Resultados: La primera etapa de la síntesis de N-decil-4-((3-formil-4-hidroxifenoxi) metil) benzamida alcanza un rendimiento de reacción del 78,66 % y en la segunda etapa 53,22%. Conclusión: Se sintetiza el compuesto N-decil-4-((3-formil-4-hidroxifenoxi) metil) benzamida según el espectro NMR caracterizado.
El Valor Agregado Bruto, la corrupción y la desigualdad en Ecuador. Un análisis descriptivo y correlacional.
Authors: Nievecela Lema Johanna Maricela , Covri Rivera Daniele , Castillo Ortega Yonimiler
Published: April 2021

Introducción. En el presente documento se analiza Valor Agregado Bruto (VAB) de los sectores económicos de la economía ecuatoriana para el periodo 2000-2019, para de esta manera determinar los sectores más influyentes de la misma; además de buscar una relación entre el crecimiento económico utilizando el Producto Interno Bruto (PIB) frente al Índice de Percepción de Corrupción (IPC) mismo que es el resultado de un fenómeno que se ve influenciado por muchos otros factores como lo es el económico; posteriormente se desarrollará  una relación entre la desigualdad expresada por el Coeficiente de Gini con el IPC. Los resultados obtenidos comparten concordancia con investigaciones en donde se evidencia que la corrupción actúa como freno para el incremento del PIB, y con ello la desigualdad. Esta investigación no busca dar conclusiones de como mejorar el IPC y la desigualdad, si no da puerta al debate sobre el problema de corrupción existente en el Ecuador.  Metodología. El diseño de investigación fue cuantitativa y cualitativa, el primero de carácter no experimental longitudinal que permitió el análisis de las variables estudiadas en el periodo de tiempo. Recopilando datos de fuentes oficiales. Resultados. Entre los resultados del análisis del Valor Agregado Bruto destaca el sector manufacturero con una participación del 11,875, seguido por el sector comercial con el 10,55% y el sector de petróleo y minas con el 10,42%, además el resultado de la correlación entre PIB e índice de Percepción de Corrupción de 0.837 indica una relación lineal directa; en tanto para la correlación de índice de percepción de Corrupción y Coeficiente de Gini existe una relación lineal inversa la ser el resultado de  -0.731 Conclusión. Se concluyó que el sector manufacturero es el más fuerte de economía ecuatoriana, sin embargo, los sectores de comercio y el petróleo y minas no se quedan muy atrás de la primera; además la corrupción y desigualdad han minado el crecimiento económico del Ecuador en el periodo analizado.
Estrategias financieras para la gestión de la cartera vencida en cooperativas de ahorro y crédito.
Authors: Masaquiza Sailema Katherine Janeth , Tite Cunalata Gabriel Marcelo , López Paredes María Alexandra , Mónica Patricia Mayorga Díaz
Published: April 2021

La presente investigación analiza la situación actual de la gestión de cartera en el período de enero – noviembre 2020 en Cooperativas de Ahorro y Crédito, la metodología exploratoria – descriptiva permitió recolectar datos, interpretar y correlacionar los resultados con investigaciones similares. Sus principales resultados son los siguientes: la pandemia del COVID-19 afectó de manera significativa al sector financiero a nivel mundial, es el caso particular del Ecuador el PIB bajó entre un 7,3% y un 9,6% o una contracción del 10.9%. Se determinó a través de análisis estadísticos de los Boletines Financieros del segmento 2, emitidos por la Superintendencia Economía Popular y Solidaria con corte hasta el mes de noviembre del 2020, en promedio se mantiene una cartera por vencer de $ 23.761.684,50 millones, lo que corresponde a un incremento del 5,5% en relación al año 2019; la cartera que no devenga interés representa un riesgo financiero menor, ya que durante el período 2020 (pandemia del COVID-19) se observa un incremento de $1.596.180,44 lo que representa el 5.2% en relación al año 2019, por lo que se diseñó un Cuadro de Mando Integral compuesto de ocho estrategias financieras que se respaldan en las normativas vigentes por parte de la Superintendencia de Economía Popular y Solidaria y la Junta de Política y Regulación Monetaria y Financiera con Resolución No. 568-2020-F orientado a las normas para la gestión del riesgo de crédito en las Cooperativas de Ahorro y Crédito.
NUTRITION IN FASTING AND NON-FASTING WOMEN DURING THE GREAT ORTHODOX LENT
Authors: Galchenko A. V. , Sherstneva A. A. , Lapik I. A. , Kulesh V. I. , Sukhno E. O. , Zarov A. Yu. , Revyakina V. A.
Published: April 2021

Aim: To compare nutrition of fasting and non-fasting women in Moscow. Methods: Daily intake of proteins, fats, carbohydrates and their fractions, water- and fat-soluble vitamins, macro-, micro- and ultra trace elements as well as the total caloric content of diet was estimated in 33 fasting and 32 non-fasting women during the Lent. Nutrition was assessed by frequency analysis using Nutrilogic software. Results: Fasting women had significantly higher intake of carbohydrates (412 g vs. 174 g) and fiber (42 g vs. 17 g), but lower intake of cholesterol (74 mg vs. 401 mg) and saturated fats (18 g vs. 30 g). Fasting women were less likely to consume insufficient amounts of vitamins B1 (12 % vs. 91 %), B3 (52 % vs. 91 %), B5 (52 % vs. 91 %), B6 (48 % vs. 88 %), B9 (42 % vs. 94 %) and E (24 % vs. 72 %), potassium (6 % vs. 41 %), magnesium (21 % vs. 91 %), iron (18 % vs. 81 %) and copper (3 % vs. 41 %). P < 0.001 for all comparisons. All women consumed insufficient amount of vitamin D with food. Conclusion: Diet of fasting women had more favourable macro- and micronutrient composition and was richer in vitamins except vitamin D. This dietary pattern may be associated with health benefits in fasting women.
INTELLIGENT DATA ANALYSIS IN BIOMEDICAL RESEARCH: CLASSIFICATION TREES
Authors: Narkevich A. N. , Vinogradov K. A. , Grjibovski A. M.
Published: April 2021

Modern analytical tasks in biomedical research require increasingly sophisticated methods of data analysis. In recent years, the term data analysis is not only related to classical statistical tests for hypothesis testing and correlation analysis for studying associations between variables. Classification tree or decision tree analysis is getting more and more frequently used in biomedical research. In this paper we present the use of classification trees in biomedical research and provide examples of their construction in the most commonly used statistical programs. The article is constructed as a problem solving exercise using classification trees with an example of a data set for creation of classification trees and description of how to build a classification tree model in IBM SPSS Statistics and StatSoft Statistica software. Moreover, we provide recommendations on how the results of this analysis should be presented in a scientific article. The use of the classification trees has a potential to contribute to better understanding of the factors behind the observed phenomena in medicine and biology.
Coinfecção Leishmaniose visceral e Vírus da Imunodeficiência Humana: perfil epidemiológico dos casos notificados em São Luís-Maranhão, Brasil
Authors: Costa Renata Kelly Espindola da , Holanda Elison Costa , Andrade Sâmia Moreira de , Nascimento Maria do Socorro Viana do , Soares Leonardo Ferreira , Oliveira Evaldo Hipólito de
Published: April 2021

A Leishmania visceral é a forma clínica das leishmanioses que está mais associada ao HIV/Aids A coinfecção Leishmania sp x HIV tem sido considerada como doença emergente em várias regiões do mundo em função da superposição geográfica das duas infecções, como consequência da urbanização das leishmanioses e da ruralização da infecção por HIV. O presente trabalho tem como objetivo de realizar estudo epidemiológico no período de 2010 a 2019 sobre infeção de leishmaniose visceral e vírus da imunodeficiência adquirida notificada na cidade de São Luís, no estado do Maranhão. Todos os dados foram coletados no mês de novembro de 2020 através do Sistema de Informações de Agravos de Notificação (SINAN) disponibilizados no site do Departamento de Informática do Sistema Único de Saúde (DATASUS). O Sistema de Informações de Agravos de Notificações (SINAN) entre os anos de 2010 é 2019 foram notificados 1994 casos de leishmaniose visceral em São Luis - Maranhão, dentre esses 321 possuíam confeição com HIV. Podemos observar que entre 2010 e 2019 uma porcentagem de 83,80% notificados são do gênero masculino, entre as faixas etária de 40-59 anos, especialmente indivíduos raça/cor preta com uma escolaridade baixa. Com base na análise podemos observar que população mais afetada são pessoas vulneráveis, com poucas instruções e os que torna mais suscetíveis, sendo necessário uma ação para conscientização dessas pessoas, uma política de saúde que abrange essa dada população. E com isso direcionar o controle da doença os esses grupos na tentativa de tornar o controle mais efetivo.
Epidemiology of leprosy indicators in the Municipality of Crato, Ceará
Authors: Costa Angélica Rodrigues de Souza , Fidelis Kleber Ribeiro , Oliveira Maraiza Gregorio de , Santos Luciano Temoteo dos , Santos Marcos Aurélio Figueiredo dos , Matos Yedda Maria Lobo Soares de , Cruz Neto João , Ribeiro Talina Guedes , Vieira Diane Sales , Braga Cicera Rejania da Silva , Silva Milena Roberta Freire da , Ferreira Renato Juciano , Oliveira Maria Aurea Soares de , Candido Antonio Silva , Arrais Francisco Matheus de Andrade , Silva Antonio Rafael da , Pereira Conceição Taís de Araújo , Sampaio Raimundo Samuel Leite , Silva Viviane Bezerra da , Nunes Bárbara Elvira Meneses de Brito , Pereira Francisco Diego , Almeida-Bezerra José Weverton
Published: April 2021

Leprosy is a comorbidity that affects numerous people all over the world, which is characterized by its affinity for the skin and peripheral nerves. The objective of this research was to carry out an analysis of the epidemiological aspects and temporal trends of leprosy indicators in the municipality of Crato. To achieve these objectives, a qualitative and quantitative research was carried out, based on data from the Notifiable Diseases Information System. Between 2007 and 2017, 477 new cases of leprosy were reported in the municipality of Crato, highlighting the year 2012 with the highest number of new cases of the disease, with emphasis on the incidence of cases in men (59.1%), while in women it was 40.8%. Of these, with a predominance of the age group between 50 to 59 years (20.7%), followed by 60 to 69 years (18.6%). According to the results proposed by this research, it can be observed that, in the last few years, there has been a significant reduction in the number of cases. To maintain this index, political commitment and quality health services for effect the service of secondary care in the municipality.
Obtenção e caracterização de farinhas de caroço de açaí (Euterper Oleracea) e de casca de bacaba (Oenocarpus Bacaba)
Authors: Barros Samara Kelly Amaral , Souza Adriana Régia Marques de , Damiani Clarissa , Pereira Andressa Sousa , Alves Denise Gomes , Clemente Rodolfo  Castilho , Costa Douglas Martins da
Published: April 2021

As frutas oriundas dos biomas Amazônia e Cerrado, como açaí (Euterper oleracea) e a bacaba (Oenocarpus bacaba), são apreciadas por seus sabores exóticos, potencial nutricional e funcional. À busca por alimentos saudáveis e a descoberta de nutrientes de cunho funcionais existentes nos resíduos frutícolas, fez com que aumentasse a relevância por subprodutos derivados das cascas e caroços ou sementes, levando para o crescimento da indústria alimentícia. Logo, o objetivo do estudo foi produzir farinha a partir do caroço de açaí e da casca da bacaba, bem como sua caracterização física, química e tecnológica. O caroço de açaí foi adquirido na cidade de Imperatriz (MA) e a bacaba foi obtida na Aldeia Pedra Branca Terra Indígena Krahô no estado do Tocantins. Os resíduos foram secos em estufa com circulação de ar, na temperatura de 50ºC. As farinhas oriundas do caroço de açaí e da casca da bacaba apresentaram valores consideráveis de nutrientes, sendo uma boa fonte de proteínas, lipídios e carboidratos, além de apresentar baixa umidade e pH ácido contribuindo como barreira contra o crescimento de microrganismos. Os valores de cinza obtidos em ambas as farinhas estão de acordo com a legislação brasileira. A farinha do caroço de açaí e da casca da bacaba apresentaram baixa luminosidade e os valores de chroma (C*) e ângulo de hue (h*) indicaram uma coloração avermelhada para todas as farinhas. Os resultados das análises tecnológicas, como índice de absorção e de solubilidade, mostram potencial para elaboração de novos alimentos.
O impacto das redes sociais na saúde dos jovens durante o período de isolamento: uma revisão integrativa
Authors: Rondon Maria Clara de Sales , Estrela Ana Cássia Gonzalez dos Santos , Sales Soenil Clarinda de , Costa Vilânia Vieira da , Santos Aldino Barbosa dos , Costa Bruna Ferreira da , Lima Natália César
Published: April 2021

Objetivo: Identificar por meio da literatura o impacto das redes sociais na saúde mental dos jovens durante o isolamento na pandemia da COVID-19 e descrever as maneiras encontradas para reduzir os riscos apresentados. Método: Trata-se de uma revisão integrativa da literatura, recorrendo-se as bases de dados: MEDLINE, IBECS, BDENF/Biblioteca Virtual de saúde, LILCAS, utilizando os descritores rede social, Saúde mental, COVID and jovens, publicados entre 2019 e 2021. Resultados: Foram encontrados doze artigos que responderam à pergunta de pesquisa. Da análise, resultaram três categorias: os efeitos nocivos à saúde mental dos jovens, a utilização e o impacto das redes sociais e formas de atenuar a problemática. Considerações finais: Os impactos oriundos do isolamento social e das redes sociais são perceptíveis e tem um longo prazo de duração, os jovens em sua grande maioria apresentam transtornos mentais graves e faz-se necessário no combate a essa problemática, o apoio dos pais e do sistema de saúde.
O uso do software IRAMUTEQ na análise de conteúdo - estudo comparativo entre os trabalhos de conclusão de curso do ProfEPT e os referenciais do programa
Authors: Klant Luciana Maria , Santos Vanderley Severino dos
Published: April 2021

O presente artigo objetiva evidenciar a usabilidade do software IRaMuTeq, analisando e comparando os resumos dos TCC, dos estudantes do Mestrado Profissional em Educação Profissional e Tecnológica – ProfEPT, disponíveis na Plataforma Sucupira em dezembro de 2019 com a bibliografia indicada nos exames de acesso ao Programa. O uso do software IRaMuTeq mostra-se como uma importante ferramenta de organização de dados para realização da análise de conteúdo, proposta por Bardin (1977), pois possibilita diversas organizações do conteúdo analisado, dentre elas as do tipo Lexográfica, Especificidades, Análise Fatorial de Correspondência (AFC), Método da Classificação Hierárquica Descendente (CHD), Análise de Similitude e Nuvem de Palavras. A aplicação do software IRaMuTeQ possibilitou realizar estas análises com mais agilidade e demonstrou que há consonância entre os termos usados pelos estudantes do ProfEPT em seus TCCs e as referências teóricas do programa. O software mostrou-se bastante útil, principalmente na fase dois da técnica de análise de conteúdo, proposta por Bardin (1977), porém, para se aplicar totalmente esta técnica é imprescindível o protagonismo do pesquisador na fase três, momento de discutir e interpretar os resultados demonstrados pelo software livre IRaMuTeq.
Aproximações com o chão da escola na vivência dos pibidianos de Educação Física
Authors: Ramalho Monique Carvalho , Caraçato Yedda Maria da Silva , Queiroz Leonardo Cordeiro de , Romero Francielli Ferreira da Rocha , Solera Bruna , Anversa Ana Luiza Barbosa , Flores Patric Paludett , Oliveira Amauri Aparecido Bassoli de , Souza Vania de Fátima Matias de
Published: April 2021

O objetivo do estudo foi investigar a representação do PIBID na formação inicial de professores de Educação Física. Participaram da pesquisa dez pibidianos, por meio do grupo focal. A interpretação das informações seguiu os encaminhamentos da análise de conteúdo. A partir dos resultados emergiram-se cinco categorias de análise: 1) O ingresso e a permanência no programa, 2) Conhecimentos sobre os objetivos do PIBID, 3) A universidade e o cotidiano escolar, 4) A aquisições de habilidades e competências docentes e 5) A influência do PIBID na Formação Inicial. Com base nos dados apresentados percebe-se a importância de uma formação teórico-prática, a necessidade de inserção dos pibidianos no cotidiano escolar, possibilitando experiências para a construção das competências para a prática pedagógica e propiciando conhecimentos da realidade escolar. Os resultados apontam que o PIBID representa uma elevação na qualidade da formação inicial.
Evolution of soil cover and dry shoot phytomass accumulation of autumn/winter cover crops and its effect on the agronomic performance of soybean grown in succession
Authors: Gimenez Guilherme Semião , Almeida Junior João Henrique Vieira de , Sambatti Vinicius Cesar , Nascimento Vagner do , Dalazen Giliardi
Published: April 2021

The cultivation of cover crops under no-tillage systems can promote positive improvements in soil attributes and promote increases in grain yield of successor crops, such as soybeans. The aim of this work was to evaluate the evolution of soil cover and accumulation of dry shoot phytomass of autumn/winter cover crops and their impact on the agronomic performance of soybean grown in succession. Black oats (Avena strigosa), rye (Secale cereale) and turnip (Raphanus sativus) were used as cover species in single crops, dual and triple intercropping, in addition to the fallow and weeded controls. The percentage of soil cover (%) and the accumulation of dry shoot phytomass were evaluated at 30, 45, 60, 75, 90 and 105 days after sowing (DAS). In soybean crop, plant height, number of productive nodes per plant, number of pods per plant, mass of a thousand grains and grain yield were evaluated. The cultivation of turnip single provided the fastest soil coverage, with 90.0% at 45 DAS. The intercropping between rye + turnip provided the largest accumulations of dry shoot phytomass, greater than 7.0 Mg ha-1 at 105 DAS. The highest soybean yields were obtained in succession to the cultivation of black oat and rye in single, yielding approximately 3,300 kg ha-1, 50% higher compared to fallow and weeded treatments.
Proposta de modernização sustentável do modelo produtivo do farelo do coco babaçu de uma reserva agroextrativista do Maranhão, Brasil
Authors: Santos Carlos Alberto Andrade Serra dos , Saldanha Ruan Carlos Gonçalves , Costa Welerson Silva , Ferreira Junior Diogenes Fontenele , Costa José de Ribamar Macedo , Costa Ivo Almeida , Nascimento Bruno Lucio Meneses , Façanha Filho Pedro de Freitas
Published: April 2021

Este trabalho tem por objetivo apresentar uma proposta de modernização sustentável do modelo produtivo do farelo do coco babaçu, como fonte de ampliação de renda para comunidade extrativista do Ciriaco - MA. Foram utilizadas observações da rotina de trabalho da comunidade extrativista do Ciriaco e entrevista com o coordenador da ATARECO para conhecer o processo de fabricação dos produtos derivados do babaçu. Os resultados demostraram que os trabalhadores extrativistas têm desperdiçado o potencial econômico do endocarpo por descartar no processo de extração da amêndoa babaçu. A cadeia atual de produção do local de estudo não possui estrutura para grandes demandas produtivas devido a maior parte desse processo ser realizado de forma manual. A produção de processamento diária na RESEX através do tradicional é em média 300 kg/dia do coco babaçu, já com a incorporação do maquinário a capacidade de processamento passa a ser 20.000 kg de coco in natura por dia. Desta forma, existe a necessidade de incorporar tecnologias nas atividades extrativistas com o intuito de impulsionar a fabricação e consequentemente a renda das famílias extrativistas. Sendo assim, esse trabalho possui relevância por levantar indicadores sobre a contribuição da fabricação mecanizada de farelo derivado do epicarpo, mesocarpo, e endocarpo do coco babaçu, para ampliação sustentável da renda das comunidades que tem o extrativismo do babaçu como meio de subsistência.
Avaliação das práticas de uso de plantas medicinais no Município de Caxias-MA
Authors: Silva Antônia Fernanda Lopes da , Barros Luciano André Assunção
Published: April 2021

O objetivo deste trabalho foi avaliar as práticas de uso de plantas medicinais e suas principais formas de preparação por moradores de um bairro no município de Caxias-MA. Trata-se de uma pesquisa descritiva, com abordagem quantitativa, realizada em um bairro do município de Caxias-Ma. Para a coleta dos dados foi utilizado um questionário semiestruturado contendo as variáveis socioeconômicas e questões abertas e fechadas sobre o uso de plantas medicinais. Para verificar a associação entre as variáveis foi utilizado o teste Exato de Fisher, sendo os dados analisados através do programa SPSS. Contabilizou-se 97 entrevistados, destes, apenas 89,7% referiram fazer o uso de plantas. Dentre estes, 86,2% eram do sexo feminino e 13,8% eram do sexo masculino. A variável renda apresentou significância estatística (p-0,034), onde 55,2% dos entrevistados afirmaram viver com menos de um salário-mínimo. Foi possivel identificar 22 plantas citadas pela população, sendo indicadas, principalmente, para má digestão, insônia, hipertensão, tosse, gripe e inflamação. Quando interrogados sobre com quem aprenderam sobre o uso de plantas, 66,0% relataram ter aprendido com ascendentes/familiares/avós/mães, enquanto nenhum dos entrevistados receberam informações oriundas de profissionais de saúde. Neste ponto, é importante que o profissional de saúde tenha conhecimento sobre as formas de uso e efeitos das plantas medicinais para que seja possível difundir mais informações sobre estas entre a população.
Use of organic waste biochar as an innovative alternative for increasing agricultural productivity in small rural communities
Authors: Gonzaga Maria Isidória Silva , Souza Danyelle Chaves Figueiredo de , Santos José Carlos de Jesus
Published: April 2021

Biochar, pyrolyzed organic waste for agronomic and environmental purposes, is a viable alternative to improve soil quality in small farm areas in the state of Sergipe, where there is a shortage of water and chemical inputs. This study evaluated the effect of single and simultaneous application of doses (t ha-1) of sewage sludge (SS) and dry coconut shell (CS) on some soil properties and sunflower growth and nutrition (Helianthus annuus L.), in São Cristóvão-SE. The experiment was carried out in a completely randomized scheme, with 6 treatments (1. SE60CS0; 2. SE30CS0; 3. SE20CS10; 4. SE10CS20; 5. SE0CS30; 6. Control (without biochar) and 5 repetitions. In the soil, pH, electrical conductivity, organic carbon, and P, K, and Na concentrations were determined. In the plant, biomass, height, chlorophyll content, and N, P, and K were evaluated. Alone, coconut biochar increased the soil pH but reduced plant N. The sludge biochar did not increase soil pH but improved the soil N and P levels, plant growth (25%), and inflorescence (33%), indicating greater benefits of joint application. In addition to improving productivity, biochar, both from sewage sludge and dry coconut shell, can improve the destination and management of these residues and, at the same time, promote the recycling of nutrients in soil.