bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep brain stimulation for treatment resistant obsessive compulsive disorder; an observational study with ten patients under real-life conditions
Authors: Abdelnaim Mohamed A. , Lang-Hambauer Verena , Hebel Tobias , Schoisswohl Stefan , Schecklmann Martin , Deuter Daniel , Schlaier Juergen , Langguth Berthold
Published: September 2023

Introduction

Obsessive-compulsive disorder (OCD) affects 2–3% of the global population, causing distress in many functioning levels. Standard treatments only lead to a partial recovery, and about 10% of the patients remain treatment-resistant. Deep brain stimulation offers a treatment option for severe, therapy-refractory OCD, with a reported response of about 60%. We report a comprehensive clinical, demographic, and treatment data for patients who were treated with DBS in our institution.

Methods

We offered DBS to patients with severe chronic treatment resistant OCD. Severity was defined as marked impairment in functioning and treatment resistance was defined as non-response to adequate trials of medications and psychotherapy. Between 2020 and 2022, 11 patients were implanted bilaterally in the bed nucleus of stria terminalis (BNST). Patients were evaluated with YBOCS, MADRS, GAF, CGI, and WHOQOL-BREF. We performed the ratings at baseline (before surgery), after implantation before the start of the stimulation, after reaching satisfactory stimulation parameters, and at follow-up visits 3, 6, 9, and 12 months after optimized stimulation.

Results

One patient has retracted his consent to publish the results of his treatment, thus we are reporting the results of 10 patients (5 males, 5 females, mean age: 37 years). Out of our 10 patients, 6 have shown a clear response indicated by a YBOCS-reduction between 42 and 100 percent at last follow-up. One further patient experienced a subjectively dramatic effect on OCD symptoms, but opted afterwards to stop the stimulation. The other 3 patients showed a slight, non-significant improvement of YBOCS between 8.8 and 21.9%. The overall mean YBOCS decreased from 28.3 at baseline to 13.3 (53% reduction) at the last follow-up. The improvement of the OCD symptoms was also accompanied by an improvement of depressive symptoms, global functioning, and quality of life.

Conclusion

Our results suggest that BNST-DBS can be effective for treatment-resistant OCD patients, as indicated by a reduction in symptoms and an overall improvement in functioning. Despite the need for additional research to define the patients’ selection criteria, the most appropriate anatomical target, and the most effective stimulation parameters, improved patient access for this therapy should be established.
Correlations between schizophrenia and lichen planus: a two-sample bidirectional Mendelian randomization study
Authors: Chen Guan-Yu , Fu Ling-ling , Ye Bin , Ao Man , Yan Ming , Feng Hong-Chao
Published: September 2023

Background

Several existing studies have shown a correlation between schizophrenia and lichen planus (LP). However, the causality of this relationship remains uncertain. Thus, this study aimed to examine the causal association between schizophrenia and LP.

Methods

A two-sample Mendelian randomization (MR) study was carried out to investigate whether schizophrenia is causally related to LP and vice versa, and genetic variants in this study were taken from previous genome-wide association studies. We used the inverse variance weighted (IVW) method as the main analysis. Furthermore, several sensitivity analyses were performed to assess heterogeneity, horizontal pleiotropy, and stability.

Results

Our results show that schizophrenia has a protective effect on LP (OR = 0.881, 95%CI = 0.795–0.975, p = 0.015). Conversely, we observed no significant relationship between LP and schizophrenia in reverse MR analysis (OR = 0.934, 95%CI = 0.851–1.026, p = 0.156).

Conclusion

Our two-sample Mendelian randomization study supports a significant causal relationship between LP and schizophrenia and finds that schizophrenia can reduce the incidence of LP. This is in contrast to previous findings and provides new insights into the relationship between LP and schizophrenia, but the exact mechanism needs further investigation.
Major depression associated with a levonorgestrel-releasing intrauterine system mimicking frontotemporal dementia: a case report
Authors: Valencia-Cifuentes Valeria , Cañas Carlos A. , Rivas Juan Carlos
Published: September 2023

This case illustrates the adverse cognitive and affective effects associated with the use of an intrauterine hormonal contraceptive, which could be confused with symptoms of early onset dementia. We present a case of a 42-year-old woman diagnosed with seronegative spondyloarthropathy who subsequently developed anxiety and depressive symptoms after the implantation of a Levonorgestrel-Releasing Intrauterine System (LNG-IUS). Three years later, she began to experience memory and attentional failures, refractory pain, and severe depression. The progression of psychiatric symptoms led to a diagnosis of bipolar affective disorder and treatment with antidepressants and anxiolytics. Due to cognitive and psychiatric symptoms, autoimmune encephalitis was considered, but no improvement was shown with treatment. Early onset dementia was suspected, and a brain PET scan revealed frontal lobe hypometabolism. An adverse effect of LNG-IUS was considered; after its removal, mood and cognitive function improvements were observed. This case report emphasizes the importance of considering organic causes of unexplained psychiatric manifestations and highlights the potential impact of hormonal interventions on mental health.
A qualitative analysis of public health officials' experience in California during COVID-19: priorities and recommendations
Authors: Burke Rita V. , Distler Anna S. , McCall Timothy C. , Hunter Emma , Dhapodkar Shruti , Chiari-Keith Larissa , Alford Aaron A.
Published: September 2023

Objectives

The aim of this study was to collect qualitative data regarding the violence faced by public health officials during the COVID-19 pandemic and create a guideline of recommendations to protect this population moving forward.

Methods

Two focus groups were conducted virtually from April 2022 to May 2022. All nine participants were public health officials from across California. A grounded theory approach was used to analyze the data from these focus groups.

Results

The main recurrent experiences among public health officials were harassment, psychological impact, systemic backlash, and burnout. Several recommendations for supporting public health officials were highlighted, including security and protection, mental health support, public awareness, and political/institutional support.

Conclusion

Our study captures the violent experiences that health officials have faced during the COVID-19 pandemic. To maintain the integrity of the public health system, timely changes must be made to support and protect health officials. Our guideline of recommendations provides a multi-faceted approach to the urgent threats that officials continue to face. By implementing these solutions, we can strengthen our public health system and improve our response to future national emergencies.
Exploring spatiotemporal trends and impacts of health resources and services on under-5 mortality in West African countries, 2010–2019: a spatial data analysis
Authors: Zeng Meng , Niu Lu
Published: September 2023

Background

West African countries experienced the highest under-5 mortality rate (U5MR), the lowest life expectancy, and the poorest economic development. This study aimed to explore the spatiotemporal trend of U5MR and spatial spillover effects of health resources and services to provide a basis for establishing health policies and international cooperative mechanisms in West Africa.

Methods

We retrieved data from the World Health Organization’s Global Health Observatory, the United Nations Human Development Report, and the Global Burden of Disease Study 2019. Joinpoint regression analysis and Moran’s I method were used to examine the temporal trend and spatial dependence of U5MR, respectively. Spatial regression analysis was used to examine the spatial spillover effects.

Results

The long-term downward trends in U5MR were divided into multiple segments by two or three change points in 2013, 2014, or 2015, and the annual percentage change after 2015 was higher than before 2015. Global Moran’s I was positive, significantly indicating positive spatial autocorrelation, which increased from 0.2850 (p = 0.0210) to 0.3597 (p = 0.0080). Based on spatial regression analysis, human development index (HDI), physicians density, nurses and midwives density, health center density, percentage of infants lacking immunization for diphtheria and measles, and coverage rate of at least one antenatal visit had negative spatial spillover effects on U5MR. HDI had the strongest negative correlation (β = −0.0187 to −0.1054, p < 0.0001). Current health expenditure (CHE) per capita had positive spatial spillover effects on U5MR.

Conclusion

This study revealed the spatiotemporal trend of U5MR in West African countries and spatial spillover effects of health resources and services. Promoting economic development, increasing health human resources, health expenditure, vaccination rate, antenatal care coverage, and the proportion of health professionals attending births not only reduced the local U5MR but also exerted spatial spillover effects on adjacent countries. The West African Health Organization may consider regional spillover mechanisms to develop regional health policy and intervention cooperation mechanisms, which will contribute to achieving the sustainable development goal on U5MR, Africa Agenda 2063, and universal health coverage.
Early breast cancer detection and differentiation tool based on tissue impedance characteristics and machine learning
Authors: Salem Soumaya Ben , Ali Samar Zahra , Leo Anyik John , Lachiri Zied , Mkandawire Martin
Published: September 2023

During Basic screening, it is challenging, if not impossible to detect breast cancer especially in the earliest stage of tumor development. However, measuring the electrical impedance of biological tissue can detect abnormalities even before being palpable. Thus, we used impedance characteristics data of various breast tissue to develop a breast cancer screening tool guided and augmented by a deep learning (DL). A DL algorithm was trained to ideally classify six classes of breast cancer based on electrical impedance characteristics data of the breast tissue. The tool correctly predicted breast cancer in data of patients whose breast tissue impedance was reported to have been measured when other methods detected no anomaly in the tissue. Furthermore, a DL-based approach using Long Short-Term Memory (LSTM) effectively classified breast tissue with an accuracy of 96.67%. Thus, the DL algorithm and method we developed accurately augmented breast tissue classification using electrical impedance and enhanced the ability to detect and differentiate cancerous tissue in very early stages. However, more data and pre-clinical is required to improve the accuracy of this early breast cancer detection and differentiation tool.
“When you get the HPV vaccine, it will prevent cervical cancer; it will act as a shield”: adolescent girls’ knowledge and perceptions regarding the human papillomavirus vaccine in Zambia
Authors: Lubeya Mwansa Ketty , Chibwesha Carla J. , Mwanahamuntu Mulindi , Mukosha Moses , Frank Simone , Kawonga Mary
Published: September 2023

Introduction

The human papillomavirus (HPV) vaccination is an important preventive measure for HPV-related conditions such as cervical cancer. In 2019, Zambia introduced a free national HPV vaccination program for 14-year-old girls. However, the adolescents’ knowledge and perceptions regarding the HPV vaccine are not well understood. Therefore, this study aimed to understand adolescent girls’ knowledge and perceptions regarding the HPV vaccine and discuss its acceptability and uptake implications.

Methods

We conducted a qualitative study in the Lusaka district between June 2021 and November 2021 using semi-structured interviews with adolescent girls aged 15–18 years regardless of their HPV vaccination status. Interviews were transcribed verbatim, and NVIVO 12 was used for data management and analysis. We coded transcripts deductively and inductively based on emerging themes. Perceptions were coded using the health belief model constructs.

Results

We interviewed 30 adolescent girls to reach saturation. Seventeen girls reported having received at least one dose of the HPV vaccine. Participants expressed variable knowledge and awareness about HPV and the HPV vaccine. Participants exhibited positive attitudes towards the HPV vaccine and perceived it as beneficial. However, there were multiple perceived barriers to vaccination, such as the need for parental consent, not being in school, concerns about vaccine side effects, and belief in myths and misinformation

Conclusion

The adolescent girls in this study showed variable knowledge and positive attitudes toward the HPV vaccine despite the many perceived barriers. To support increased HPV vaccine acceptability and uptake among adolescent girls in Zambia, it is critical to actively engage stakeholders involved in HPV vaccination, such as adolescents and their parents, and debunk myths and misconceptions about HPV vaccination. Health education in schools and communities should be implemented to increase knowledge about HPV and HPV vaccination among adolescents and their parents.
Urbanization gradient, diet, and gut microbiota in Sub-Saharan Africa: a systematic review
Authors: Paulo Linda Simon , Msema Bwire George , Klipstein-Grobusch K. , Kamuhabwa Appolinary , Kwesigabo Gideon , Chillo Pilly , Asselbergs Folkert W. , Lenters Virissa C.
Published: September 2023

Introduction

As Sub-Saharan Africa (SSA) undergoes rapid urbanization changes in diet and lifestyle have contributed to a rise in non-communicable diseases (NCDs) across the region. Changes in gut microbiota which play an important role in human health may be an underlying driving factor. While evidence suggests that the gut microbiota differs between the extreme levels of economic development (least vs highly developed), it is not well-established which factors along the urbanization gradient are most influential, especially for SSA. This systematic review analyzed published articles from SSA countries that examined the differences in the composition and diversity of gut microbiota along the urbanization gradient. The findings of this review have important implications for understanding the impact of urbanization on human health in the SSA.

Methods

Peer-reviewed articles that examined the link between the urbanization gradient, dietary patterns, and gut microbiota using culture-independent techniques were included in the review.

Results

A total of 3,265 studies were identified and screened. Eighty-nine (89) studies underwent full-text review, and 23 studies were extracted and included for final analysis. Among these studies, it was observed that hunter-gatherers had high alpha diversity (within-person variation) and beta diversity (between-person variation) in their gut microbiota compared to rural and urban residents in SSA. However, there were inconsistent differences between rural and urban at the individual taxa levels, potentially due to limited statistical power and large variability in the study techniques and designs. Similarly, there were no clear differences in the relative abundance of genera across the urbanization gradient. Additionally, both diet and intestinal parasites were associated with the composition and diversity of the gut microbiota.

Conclusion

The review revealed there are variations in both alpha and beta diversity of the gut microbiota across the urbanization gradient with a higher diversity observed in rural areas. However, we did not observe significant differences in the relative abundance at phyla or genus levels consistently across the urbanization gradient. Moreover, our findings suggest that the mode of subsistence, diet, and intestinal parasites play a role in shaping the composition and diversity of the gut microbiota in SSA.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021251006, identifier CRD42021251006.
Vocal pain expression augmentation for a robopatient
Authors: Protpagorn Namnueng , Lalitharatne Thilina Dulantha , Costi Leone , Iida Fumiya
Published: September 2023

Abdominal palpation is one of the basic but important physical examination methods used by physicians. Visual, auditory, and haptic feedback from the patients are known to be the main sources of feedback they use in the diagnosis. However, learning to interpret this feedback and making accurate diagnosis require several years of training. Many abdominal palpation training simulators have been proposed to date, but very limited attempts have been reported in integrating vocal pain expressions into physical abdominal palpation simulators. Here, we present a vocal pain expression augmentation for a robopatient. The proposed robopatient is capable of providing real-time facial and vocal pain expressions based on the exerted palpation force and position on the abdominal phantom of the robopatient. A pilot study is conducted to test the proposed system, and we show the potential of integrating vocal pain expressions to the robopatient. The platform has also been tested by two clinical experts with prior experience in abdominal palpation. Their evaluations on functionality and suggestions for improvements are presented. We highlight the advantages of the proposed robopatient with real-time vocal and facial pain expressions as a controllable simulator platform for abdominal palpation training studies. Finally, we discuss the limitations of the proposed approach and suggest several future directions for improvements.
Prevalence of female genital mutilation and associated factors among daughters aged 0–14 years in sub-Saharan Africa: a multilevel analysis of recent demographic health surveys
Authors: Ayenew Asteray Assmie , Mol Ben W. , Bradford Billie , Abeje Gedefaw
Published: September 2023

Background

Female genital mutilation (FGM) is a harmful traditional practice involving the partial or total removal of external genitalia for non-medical reasons. Despite efforts to eliminate it, more than 200 million women and girls have undergone FGM, and 3 million more undergo this practice annually. Tracking the prevalence of FGM and identifying associated factors are crucial to eliminating the practice. This study aimed to determine the prevalence of FGM and associated factors among daughters aged 0–14 years.

Methods

The most recent Demographic Health Survey Data (DHS) datasets from sub-Saharan African countries were used for analysis. A multilevel modified Poisson regression analysis model was applied to identify factors associated with FGM. Data management and analysis were performed using STATA-17 software, and the pooled prevalence and adjusted odds ratio (AOR) with a 95% confidence interval (CI) were reported. Statistical significance was set at p ≤ 0.05.

Results

The study included a weighted sample of 123,362 participants. The pooled prevalence of FGM among daughters aged 0–14 years in sub-Saharan Africa was found to be 22.9% (95% CI: 16.2–29.6). The daughter's place of birth (AOR = 0.54, 95% CI: 0.48–0.62), mother's age (AOR = 1.72, 95% CI: 1.4–2.11), father's education (AOR = 0.92, 95% CI: 0.87–0.98), mother's perception about FGM (AOR = 0.42, 95% CI: 0.35–0.48), FGM as a religious requirement (AOR = 1.23, 95% CI: 1.12–1.35), mother's age at circumcision (AOR = 1.11, 95% CI: 1.01–1.23), residing in rural areas (AOR = 1.12, 95% CI: 1.05–1.19), and community literacy level (AOR = 0.90, 95% CI: 0.83–0.98) were factors associated with FGM.

Conclusion

The high prevalence of FGM among daughters aged 0–14 years in sub-Saharan Africa indicates the need for intensified efforts to curb this practice. Addressing the associated factors identified in this study through targeted interventions and policy implementation is crucial to eradicate FGM and protect the rights and well-being of girls.
Virtual reality public speaking training: effectiveness and user technology acceptance
Authors: Bachmann Manuel , Subramaniam Abimanju , Born Jonas , Weibel David
Published: September 2023

Public speaking is a fundamental task in many professional or personal situations. At the same time, there is widespread fear of it, and it takes practice to present well. Previous studies suggest that Virtual Reality Public Speaking Training (VRPST) offers a promising opportunity for this. However, studies evaluating objective and subjective indicators are lacking so far, and valid control conditions are missing in previous studies. We aimed to overcome these drawbacks. In our experiment, participants (N = 42) had the task of presenting a card game to a four-person audience using five provided PowerPoint slides within a time limit of 5 minutes. They prepared either using VRPST or using common self-directed preparation (control condition), being randomly assigned to a condition. Both groups were instructed to prepare for the task at home and given 30 min to learn the rules of the game and present them using the slides. The control group was given an additional 30 min to prepare individually for the presentation task at home. The experimental group received an additional 30-min VRPST session. This training session was done without specific feedback and the presentation was repeated three times. The quality of the rule explanation, the audience-assessed presentation quality, and the subjects’ self-assessed presentation quality were measured. Our results indicate that the VRPST is effective. Subjects who completed the VRPST did a better job of explaining the rules and were better rated by the audience. In addition, the experimental subjects also tended to rate their presentation better in the VRPST condition. Further analyses of those participants who completed the VRPST show high technology acceptance. Our results show the VR training had a significant performance-enhancing effect and that participants would use the VRPST if it were available to them. It seems that practicing a presentation in VR is useful and even better than a conventional preparation.
How Tycho Brahe’s recordings in 1572 support SN 1572 as a type I(a) supernova
Authors: Hinse Tobias C. , Dorch Bertil F. , Occhionero Lars V. T. , Holck Jakob P.
Published: September 2023

The 450th anniversary of the discovery of the SN 1572 supernova event was celebrated in 2022. A closer look at the historical development of the field of supernova astronomy reveals the scientific importance of Tycho Brahe’s 1572 observations of this “new star.” In their quest to learn more about the new type of stellar explosion and subsequent evolution, the initial protagonists in this field (Baader and Zwicky among others) gradually turned their attention to the final remnant state of these supernova events. Since the remnant object thought to be associated with the extragalactic supernova event was found to be very dim, the focus quickly shifted toward nearby galactic events. It is at this point where Tycho Brahe’s observations played an important and often overlooked role in the context of the development of stellar evolution as a scientific field. Tycho Brahe’s meticulous and detailed recordings of the change in brightness of the new star not only allowed modern astronomers to classify SN 1572 as a supernova event but also helped them pinpoint the exact astrometric location of SN 1572. These findings helped to empirically link extragalactic supernova events to nearby past supernova remnants in the Milky Way. This enabled subsequent observations allowing further characterization. Transforming the historical recordings to a standardized photometric system also allowed the classification of SN 1572 as a type I supernova event.
Mungbean and pumpkin protein isolates as novel ingredients for the development of meat analogs using heat-induced gelation technique
Authors: Baig Mohammad Affan , Ajayi Feyisola Fisayo , Mostafa Hussein , Sivapragasam Nilushni , Maqsood Sajid
Published: September 2023

Mungbean and pumpkin are rich source of proteins and nutrients which could be utilized in novel food formulations. This study involves formulation of meat analog using mungbean protein isolate (MBPI) and pumpkin protein isolates (PPI) through optimization process using Box–Behnken Design (BBD) of response surface methodology (RSM). MBPI and PPI were used as base ingredients for the development of meat alternatives using an innovative heat-induced gelation process. Methylcellulose (MC) and gum Arabic were used as supporting matrices for obtaining desired texture of the meat analog. The emulsifying activity, water-holding capacity, and oil-holding capacity of MBPI and PPI were analyzed. The set of physicochemical response factors used in RSM was moisture content, protein content, color, and textural properties of the formulated meat analogs. The selected independent variables were set at three levels (−1, 0, 1) with protein ratio (20:10, 15:15, and 10:20 of MBPI-PPI), Water (32, 37, and 42%), and MC (5, 6, and 7%). RSM results showed that the model effectively described the correlation between the independent variables (protein ratio, water percentage, and MC percentage) and the response factors. The microstructure of the analog showed porous and fibrous structures. It was observed that the degree of cross-linking between protein molecules could have impacted the textural properties that were associated with viscoelastic characteristics as reflected in the rheological analysis. Overall, the study shows that the mungbean and pumpkin seed proteins could be utilized as a potential ingredient to improve the textural properties of the meat analog, while it is also recommended to explore such proteins with other mechanical processing techniques like extrusion.
Alternative to antibiotic growth promoters: beneficial effects of Saccharomyces cerevisiae and/or Lactobacillus acidophilus supplementation on the growth performance and sustainability of broilers’ production
Authors: Attia Youssef A. , Basiouni Shereen , Abdulsalam Nisreen M. , Bovera Fulvia , Aboshok Afaf A. , Shehata Awad A. , Hafez Hafez M.
Published: September 2023

Although antibiotics growth promoters (AGPs), including zinc-bacitracin (ZnB), can threaten human health due to developing antimicrobial resistance, as well as drug residue in animal and poultry products, ZnB is still widely used, particularly in developing countries, for the sustainability of poultry farming. The present investigation aims to assess the use of Saccharomyces cerevisiae and Lactobacillus acidophilus, with or without a prebiotic (mannooligosaccharide, MOS), as alternatives to ZnB. For this reason, 150 one-day-old chicks were grouped into six groups, designated negative control, LA, SC, ZnB, SA + MOS, and LA + MOS (5 replicates of 5 chicks for each group). Chicks kept in the control group were fed the basal diet. Chickens kept in LA and SC groups received L. acidophilus, S. cerevisiae at a 1 g/kg diet and 2 g/Kg, respectively. Chickens kept in ZnB received ZnB at 0.5 g/kg. Chicks kept in the SC + MOS and LA + MOS were fed a basal diet containing 2 g S. cerevisiae + 1 g MOS/kg or 1 g L. acidophilus + 1 g MOS /kg, respectively. The efficacy was assessed based on the growth performance, carcass traits, meat quality, nutrient digestibility, and blood biochemistry composition during the entire trial 1–36 days of age. Results showed that chicks kept in the SC group had greater BW than the control (p < 0.05). Chicks kept in the SC, LA, SC + MOS, and LA + MOS consumed less feed than the control and Zn-B groups (p < 0.05). Supplementation with S. cerevisiae resulted in a better (p < 0.05) feed conversion rate (FCR) than the control group. Supplementation with L. acidophilus + MOS significantly increased (p < 0.05) the relative liver weight compared to those supplemented with ZnB, S. cerevisiae, and L. acidophilus. In addition, supplementation with ZnB-induced spleen hypertrophy compared to S. cerevisiae and L. acidophilus-supplemented groups (p < 0.05). Plasma, meat, and liver cholesterol, as well as the cholesterol-to-lipid ratio of meat and liver, were significantly decreased (p < 0.05) in both SC and LA groups compared to the control group. Our research indicates that adding 2 g/kg of S. cerevisiae to broiler feed can effectively replace ZnB and enhance productive performance and economic profits, making it a viable and sustainable option for broiler farming.
Automation of Winglet Wings Geometry Generation for Its Application in TORNADO
Authors: Rodríguez-Sevillano Ángel Antonio , Bardera-Mora Rafael , López-Cuervo-Alcaraz Alejandra , Anguita-Mazón Daniel , Matías-García Juan Carlos , Barroso-Barderas Estela , Fernández-Antón Jaime
Published: September 2023

The paper outlines an algorithm for the rapid aerodynamic evaluation of winglet geometries using the TORNADO Vortex Lattice Method. It is a very useful tool to obtain a first approximation of the aerodynamic properties and for performing an optimization of the geometry design. The TORNADO tool is used to systematically calculate the aerodynamic characteristics of various wings with wingtip devices. The fast response of the aerodynamic models allows obtaining a set of results in a remarkably short time. Therefore, the development of an algorithm to generate wing geometries with great ease and complex shapes is of vital importance for the mentioned optimization process. The basic outline of the algorithm, the equations defining the wing geometries, and the results for unconventional wingtip devices, such as blended winglets and spiroid winglets, are presented. Finally, this algorithm allows designing a procedure to study the improvement of aerodynamic properties (lift, induced drag, and moment). Some examples are included to illustrate the capabilities of the algorithm.
Adjoint and Direct Characteristic Equations for Two-Dimensional Compressible Euler Flows
Authors: Ancourt Kevin , Peter Jacques , Atinault Olivier
Published: September 2023

The method of characteristics is a classical method for gaining understanding in the solution of a partial differential equation. It has recently been applied to the adjoint equations of the 2D steady-state Euler equations and the first goal of this paper is to present a linear algebra analysis that greatly simplifies the discussion of the number of independent characteristic equations satisfied along a family of characteristic curves. This method may be applied for both the direct and the adjoint problem. Our second goal is to directly derive in conservative variables the characteristic equations of 2D compressible inviscid flows. Finally, the theoretical results are assessed for a nozzle flow with a classical scheme and its dual consistent discrete adjoint.
Analysis of Brain Stress in Response to Temperature Changes under Agricultural Work Using Electroencephalogram Measurement
Authors: Hwang Seok-Joon , Nam Ju-Seok
Published: September 2023

Agricultural workers suffer from various physical problems and mental stress, including depression and insomnia. Various factors affect brain stress, including harsh agricultural working conditions. Further brain stress may also be due to changes in working conditions such as temperature, noise, and vibration. This study aimed to determine the brain stress in response to ambient temperature changes under agricultural work using agricultural machinery. The electroencephalograms (EEGs) of 17 agricultural workers who work using various agricultural machines was measured and analyzed. The EEG was measured for 3 min at the inactive and active state of agricultural work, respectively, at 24 °C, 28 °C, and 32 °C. The EEG was analyzed using the stress indices such as spectral edge frequency 95% (SEF95%), relative gamma power (RGP), and EEG-based working index (EWI). The EEG analysis indicated that brain stress was generated when the subjects performed the agricultural work after an inactive state. Additionally, as the temperature increased to ≥24 °C, the brain regions where SEF95%, RGP, and EWI exhibited an increase were identified. The findings of this study can be used as basic data in determining the working stress in agricultural workers during work as the ambient temperature changes from 24 °C to 32 °C.
Analysis of Spatial and Temporal Variability and Coupling Relationship of Soil Water and Salt in Cultivated and Wasteland at Branch Canal Scale in the Hetao Irrigation District
Authors: Zhao Yi , Shi Haibin , Miao Qingfeng , Yang Shuya , Hu Zhiyuan , Hou Cong , Yu Cuicui , Yan Yan
Published: September 2023

The Hetao Irrigation District is a typical salinized irrigation district in China, and soil salinization restricts agricultural development. To explore the spatial and temporal variability of soil water and salt and the coupling relationship in the Hetao Irrigation District, a field experiment was carried out at the scale of the Yichang Irrigation District branch canal in the downstream of the Hetao Irrigation District. Fifty-three soil sampling points were established to analyze the spatial and temporal variability of soil water content and total salt content and the coupling relationship using geostatistics and the coupling degree model. The results showed that soil water content in the study area belonged to medium variability and weak variability, and soil total salt content belonged to strong variability and medium variability. The theoretical models of soil water content and total salt content semi-variance function in the study area following the Gaussian model, with the block-base ratio less than 25%, with strong spatial autocorrelation, and the spatial correlation gradually increased with the increase of soil depth. The total salt content of the soil in the study area was interpolated with higher accuracy using radial basis functions as compared to ordinary kriging interpolation. In terms of temporal changes in salinity, the average salt accumulation rate of the 0–100 cm soil layer in the study area was 20.17% when salinity increased from May to June; the average desalination rate was 16.37% when salinity decreased from June to August. The main factors affecting soil salinity in cultivated land during the growing period were irrigation, precipitation, and planting crops, and the main factors affecting soil salinity in wasteland were precipitation and topography. The average coupling degree of soil water and salt in wasteland in the study area was lower than that of cultivated land, ranging from 65.15% to 86.59% of that of cultivated land. The level of coordination is marginal coordination for cultivated land and marginal disorder for wasteland. The study provides a theoretical basis for the prevention and control of soil salinization in arid areas.
Corn (Zea mays L.) Production in Living Mulch Systems Using White Clover (Trifolium repens L.) under Different Nitrogen Fertilization Rates
Authors: Quinby Marcia Pereira , Nave Renata La Guardia , Sykes Virginia , Bates Gary , Sams Carl , de Almeida Otávio Goulart
Published: September 2023

The use of living mulch (LM) in corn (Zea mays L.) production must be evaluated under different N fertilization levels. The objective of this study was to determine the optimum amount of N fertilization in white clover (Trifolium repens L. (WC)) LM in corn. The study was conducted in Spring Hill, TN, from 2020 to 2021. The treatments were [C-0] no LM + no N, [C-135] no LM + 135 kg/ha N, [CLM-0] LM + no N, [CLM-45] LM + 45 kg/ha N, [CLM-90] LM + 90 kg/ha N, and [CLM-135] LM + 135 kg/ha N. We evaluated the LM mass and corn production (silage and grain). In general, the LM mass was higher with CLM-45, CLM-90, and CLM-135 during both years. Corn silage production was higher in 2020 compared with 2021 (6.8 and 2.8 Ton/ha, respectively), and showed differences among treatments. The production of corn grain showed the same response pattern with a higher value in 2020 than in 2021 (1.8 and 0.1 Ton/ha, respectively). Thus, the use of LM did not increase corn silage or grain production, even receiving a high N rate as in conventional systems.
Mechanical Properties of Al–Mg–Si Alloys (6xxx Series): A DFT-Based Study
Authors: Pius Kipkorir Kirui , Ongwen Nicholas O. , Mageto Maxwell , Odari Victor , Gaitho Francis Magiri
Published: September 2023

Al–Mg–Si alloys are used in aircraft, train, and car manufacturing industries due to their advantages, which include non-corrosivity, low density, relatively low cost, high thermal and electrical conductivity, formability, and weldability. This study investigates the bulk mechanical properties of Al–Mg–Si alloys and the influence of the Si/Mg ratio on these properties. The Al cell was used as the starting structure, and then nine structures were modeled with varying percentages of aluminium, magnesium, and silicon. Elastic constant calculations were conducted using the stress–strain method as implemented in the quantum espresso code. This study found that the optimum properties obtained were a density of 2.762 g/cm3, a bulk modulus of 83.3 GPa, a shear modulus of 34.4 GPa, a Vickers hardness of 2.79 GPa, a Poisson’s ratio of 0.413, a Pugh’s ratio of 5.42, and a yield strength of 8.38 GPa. The optimum Si/Mg ratio was found to be 4.5 for most of the mechanical properties. The study successfully established that the Si/Mg ratio is a critical factor when dealing with the mechanical properties of the Al–Mg–Si alloys. The alloys with the optimum Si/Mg ratio can be used for industrial applications such as plane skins and mining equipment where these properties are required.
The Association between Charolais Cows’ Age at First Calving, Parity, Breeding Seasonality, and Calf Growing Performance
Authors: Šlyžienė Birutė , Mečionytė Indrė , Žilaitis Vytuolis , Butkienė Eglė , Anskienė Lina , Šlyžius Evaldas , Palubinskas Giedrius
Published: September 2023

The objective of this study was to evaluate the impact of cows’ calving ages and newborn calf body weight on the pre-weaning growth rates of calves under the farming conditions of a northeastern European country. The females were purebred Charolais cows that calved between 2019 and 2022. A total of 130 calves (bulls = 76; heifers = 54) were observed during the evaluation. The investigation showed that, based on gender, bulls had a 4.28% higher birth weight than heifers (p < 0.05). The gender of the calves affected their weight, indicating that newborns bulls were significantly heavier. Calf gender affected calf growing performance. Male calves’ weight gain was higher than that of females in the time before weaning (210 days). The highest gain of bulls was observed from 211 days to 365 days after birth. The average daily weight of male calves during this period was 6.16% (p < 0.001) higher compared to the period up to 210 days after birth. Heifers had a higher daily weight in the period up to 210 days after birth, and the daily weight gain was 12.9% (p < 0.001) higher in this period compared to the period from 211 to 365 days after birth. We observed a higher weight gain in calves from mothers with a higher number of calvings. Being born from cows with four or more calvings had a significant effect on the weight gain of calves in the period up to 210 days (p < 0.05). In the period up to 210 days, the weight gain of calves born from cows with two calvings was the lowest and was 9.79% lower compared to calves born from cows with four and more calvings (p < 0.05). The best weights were obtained from calves born in the spring and autumn seasons. Calves born in spring, summer, and autumn differed in weight by 0.37 kg. The calves of cows that were inseminated in the autumn season had the highest gain in the period up to 210 days and also from 210 to 365 days (p < 0.05). In our study, significantly higher average birth weight of calves was detected in autumn compared to summer and winter (p < 0.05). Also, the highest gain was found from 211 to 365 days after birth in the summer season, but the difference was only 1.47% (p < 0.05).
Xylazine Infusion during Equine Colic Anesthesia with Isoflurane and Lidocaine: A Retrospective Study
Authors: Ruíz-López Patricia , Cuypers Charlotte , Schauvliege Stijn
Published: September 2023

This retrospective study investigated the effect of a xylazine infusion on heart rate; mean arterial pressure; blood gases; anesthetic and dobutamine requirements; recovery quality and duration; percentage of death/survival; and days to die/discharge in horses after colic surgery under partial intravenous anesthesia with isoflurane and lidocaine infusion. Anesthetic records of equine colic surgery were reviewed from similar periods in 2020–2021 and 2021–2022. In both groups, after sedation with xylazine 0.7 mg/kg intravenously (IV) and induction with ketamine 2.2 mg/kg and midazolam 0.06 mg/kg IV, anesthesia was maintained with isoflurane and lidocaine (bolus 1.5 mg/kg IV, infusion 2 mg/kg/h). Group L (2020–2021, n = 45) received xylazine 0.2 mg/kg IV before recovery, group XL (2021–2022, n = 44) received xylazine 0.5 mg/kg/h IV intraoperatively. In group XL, minimal (p = 0.04) and average (p = 0.04) heart rate, intraoperative hematocrit (p = 0.001), minimal (p = 0.002) and maximal (p = 0.04) dobutamine administration rate, animals requiring ketamine top-ups (p = 0.04), and the number of days to discharge (p = 0.02), were significantly lower compared to group L. During recovery in group XL, the time to sternal recumbency (p = 0.03) and time to first attempt (p = 0.04) were significantly longer. This retrospective study suggests that a xylazine infusion may have beneficial effects on horses undergoing colic surgery. Further prospective studies are necessary.
Fenofibrate Decreases Ethanol-Induced Neuroinflammation and Oxidative Stress and Reduces Alcohol Relapse in Rats by a PPAR-α-Dependent Mechanism
Authors: Ibáñez Cristina , Acuña Tirso , Quintanilla María Elena , Pérez-Reytor Diliana , Morales Paola , Karahanian Eduardo
Published: September 2023

High ethanol consumption triggers neuroinflammation, implicated in sustaining chronic alcohol use. This inflammation boosts glutamate, prompting dopamine release in reward centers, driving prolonged drinking and relapse. Fibrate drugs, activating peroxisome proliferator-activated receptor alpha (PPAR-α), counteract neuroinflammation in other contexts, prompting investigation into their impact on ethanol-induced inflammation. Here, we studied, in UChB drinker rats, whether the administration of fenofibrate in the withdrawal stage after chronic ethanol consumption reduces voluntary intake when alcohol is offered again to the animals (relapse-type drinking). Furthermore, we determined if fenofibrate was able to decrease ethanol-induced neuroinflammation and oxidative stress in the brain. Animals treated with fenofibrate decreased alcohol consumption by 80% during post-abstinence relapse. Furthermore, fenofibrate decreased the expression of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukins IL-1β and IL-6, and of an oxidative stress-induced gene (heme oxygenase-1), in the hippocampus, nucleus accumbens, and prefrontal cortex. Animals treated with fenofibrate showed an increase M2-type microglia (with anti-inflammatory proprieties) and a decrease in phagocytic microglia in the hippocampus. A PPAR-α antagonist (GW6471) abrogated the effects of fenofibrate, indicating that they are dependent on PPAR-α activation. These findings highlight the potential of fenofibrate, an FDA-approved dyslipidemia medication, as a supplementary approach to alleviating relapse severity in individuals with alcohol use disorder (AUD) during withdrawal.
Evaluation of Antioxidant and Antifungal Activity of Chamaecyparis obtuse Extract for Use in Oral Herbal Medicine
Authors: Kim Yu-Rin , Kim Gyoo-Cheon , Nam Seoul-Hee
Published: September 2023

The aim of this study was to investigate the antifungal and antioxidant activities of Chamaecyparis obtusa (C. obtusa) extract (COE) against Candida albicans (C. albicans). Methods: The antioxidant activity was determined using three methods based on 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) scavenging, total polyphenol measurement, and total flavonoid measurement. In addition, the survival rate of human keratinocytes (HaCaT) was checked to confirm their stability. A one-way ANOVA also confirmed the antifungal activity of COE against C. albicans and its proliferative effect on HaCaT cells. In addition, to confirm the difference between each group, the Tukey HSD test was performed as a post hoc analysis, and the significance level was set at 0.05 as a two-tailed test. Results: COE was found to contain 424.150 mg GAE/g of polyphenols, 127.566 mg CE/g of flavonoids, and 83.594% of radical scavenging activity. Furthermore, 30 mg/mL of this extract exhibited complete antifungal activity. In addition, a noticeable killing effect on C. albicans was observed as the concentration of the extract increased. For instance, at a 2.5 mg/mL dosage of COE, HaCaT cells were safe, but C. albicans showed a distinct antifungal effect. Conclusions: COE has antioxidant and antifungal activity, so it has a high potential as an effective natural antifungal agent. Therefore, oral gargle containing COE is expected to be a safe and effective treatment in oral candidiasis in clinical practice.
Novel Frequency-Reconfigurable Antennas with Ring Resonators and RF Switches: Enhancing Versatility and Adaptability in Wireless Communication Systems
Authors: Gençoğlan Duygu Nazan , Palandöken Merih , Çolak Şule
Published: September 2023

This study introduces innovative designs for frequency-reconfigurable antennas that utilize ring resonators combined with either PIN diodes or RF switches. These designs enhance the versatility, adaptability, and overall performance of the antennas in wireless communication systems. By controlling the switches and ring resonator, the antenna’s resonant frequencies and bandwidths can be adjusted, allowing for compatibility with various communication standards and frequency ranges. The proposed antenna exhibits four distinct operational states, each characterized by different resonance frequencies and operating frequency bands. Return loss, radiation pattern, radiation efficiency, and surface current distribution are analyzed for each state. State-1 (ON-ON) and State-2 (OFF-ON), which are characterized by resonance frequencies of 2.4 GHz and 3.33 GHz respectively, offer ranges suitable for Wi-Fi, Bluetooth, ISM, and IoT applications. State-3 (ON-OFF), with a resonance frequency of 3.0 GHz and bandwidth spanning from 2.59 GHz to 3.643 GHz, complies with Wi-Fi, Wi-Fi 6, and IoT requirements. State-4 (OFF-OFF) covers the band centered around 3.45 GHz. It is compatible with many applications such as 5G mid-band, Wi-Fi 6E, IoT, and cellular systems. The proposed antenna designs are versatile and compact since the overall antenna dimensions are 25 × 18 × 1.6 mm3. The radiation efficiency of the antenna configuration varies depending on operational states. By utilizing the advantages of both ring resonators and RF switches, the proposed antenna configurations offer new solutions that enhance their performance in wireless communication systems. This study compares the effects of using PIN diodes and SPDT switches on the performance of antennas and also examines the DC biasing effect on antenna characteristics. The simulation results are validated by the experimental analysis. The proposed antenna designs offer a new approach for wireless communication systems by using both ring resonators and RF switches.