bluuebunny/crossref_metadata_2025 huggingface dataset:
Cuestión de formas: Notas a la relación documental cubana entre archivo y disidencias.
Authors: Florencia Santucci Silvana
Published: January 2025

El artículo explora la relación entre “archivo” y “disidencia” en dos cortometrajes
cubanos: P.M (1961) de Orlando Jiménez Leal y Alberto «Sabá» Cabrera Infante y
Gente en la playa (1960) Néstor Almendros. Ambos interrogan la forma en que se
estetiza lo documentable y disputan el régimen representativo de la Revolución. Por
otro lado, se explora cómo estos cortos refuerzan la tesis de la desestabilización de
los archivos ante las narrativas oficiales.
La crisis migratoria en Bielorrusia (2021) contada por Euronews y Sputnik: análisis comparativo de framing basado en citas de fuentes políticas.
Authors: Azpíroz Manero María Luisa
Published: January 2025

Se analiza de forma comparativa la cobertura de Euronews y Sputnik de la crisis
migratoria en la frontera polaca-bielorrusia en noviembre de 2021, realizando un
análisis de contenido y de framing con base en las fuentes citadas. Los resultados
demuestran sesgos hacia la parte europea o bielorrusa del conflicto, pero ambos
medios también dan voz a las posturas enfrentadas. Se ofrece un sistema de
análisis de framing sencillo y replicable.
Subcoalition Cluster Analysis: A New Method for Modeling Conflict in Organizations
Authors: Ganz Scott C. , Schiff Daniel S.
Published: January 2025

The renewed interest among managers and management researchers in stakeholder governance has also underscored the shortage of quantitative methods available for studying business firms as political systems. A critical problem for researchers applying coalition-based theories of organizational politics to observational data is that the units of analysis, coined “subcoalitions,” are often unobservable. This paper introduces subcoalition cluster analysis (SCA) as a new computational framework for analyzing intrafirm conflict that permits researchers to model groups of heterogeneous actors in terms of a smaller set of representative subcoalitions. The SCA approach to identifying latent fault-lines among groups of actors is based on widely held ideas in management research about the structure of intrafirm coalition politics, is computationally practicable in settings with many alternatives or actors, and can be straightforwardly applied to observational settings with incomplete data on actor preferences. We then apply SCA to two cases in which an organization characterized by multiple, partially inconsistent goals and stakeholders with heterogeneous preferences face a politically contested decision. In both cases, we first analyze preference data using SCA to identify the subcoalition structure that best characterizes the set of actors in the organization. We then use the SCA output as a dependent variable in an analysis of the predictors of subcoalition membership in the first case and as an independent variable in an analysis of the changing patterns of social influence in the second.

This paper was accepted by Lamar Pierce, organizations.

Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2020.00013 .
Qualitative methods: the missing link in orthopaedic research
Authors: Jones Samantha , Tyson Sarah
Published: January 2025

Cite this article: Bone Joint Res 2025;14(1):16–19.
Random sparse sampling and compressive sensing based reconstruction for computational optical scanning holography
Authors: Yoneda Naru , Sugimoto Masamitsu , Saita Yusuke , Matoba Osamu , Nomura Takanori
Published: January 2025

Optical scanning holography (OSH) is one of the single-pixel imaging (SPI) techniques. Although OSH can obtain an incoherent hologram using a single-pixel detector, OSH needs a complicated optical setup to generate Fresnel zone patterns (FZPs). Computational OSH (COSH) has been proposed to overcome the complexity of OSH by using a spatial light modulator (SLM). However, the measurement time of COSH is restricted by the refresh rate of an SLM for changing FZPs. While the number of measurements can be reduced by applying compressive sensing in conventional OSH, the scanning trajectory of FZPs is limited to the spiral manner because of the requirement of sequential scanning using galvo mirrors. The spiral scanning trajectory induces undesired artifacts in reconstructed images under sparse sampling conditions. If holograms can be randomly subsampled, these undesired artifacts can be reduced. In this paper, under COSH’s configuration, random sparse sampling of a hologram is proposed to overcome the problem of the limited trajectory of FZPs by discretely displaying FZPs on an SLM. In addition, compressive sensing is applied to reconstruct an object image from a randomly sampled hologram. The feasibility of the proposed method is confirmed numerically and experimentally. The experimental results indicate that the proposed method can identify the object even when the hologram is randomly subsampled with a sampling rate of 5%.
High-fidelity image reconstruction in multimode fiber imaging through the MITM-Unet framework
Authors: Feng Zefeng , Yue Zengqi , Zhou Wei , Xu Baoteng , Liu Jialin , Sun Jiawei , Xiong Daxi , Yang Xibin
Published: January 2025

Using a single multimode fiber for both illumination and imaging offers notable advantages in developing ultra-thin imaging probes. However, uneven speckle illumination introduces additional noise, complicating high-precision reconstruction of complex grayscale images, which remains challenging for traditional methods. In this study, we first optimize the image reconstruction framework by combining the inverse transmission matrix approach with deep neural networks, enhancing interpretability and delivering exceptional performance in reconstructing complex images. To address the noise introduced by uneven speckle illumination, we increase the target exposure and effectively integrate information from multiple illumination conditions. Results show that our proposed Multi-speckle Illumination type Inverse Transmission Matrix-Unet (MITM-Unet) method significantly outperforms the Single-speckle illumination type (SITM-Unet). Specifically, images reconstructed with MITM-Unet achieve a structural similarity index of 0.59 and a Pearson correlation coefficient of 0.91, compared to SITM-Unet’s 0.38 and 0.77. These findings underscore the effectiveness of the MITM-Unet method in achieving high-quality imaging of complex grayscale targets, providing valuable insights into the imaging capabilities of single multimode fiber systems. This work holds promise for advancing simpler, more compact wide-field endomicroscopic imaging using multimode fibers.
Natural language processing to evaluate texting conversations between patients and healthcare providers during COVID-19 Home-Based Care in Rwanda at scale
Authors: Lester Richard T. , Manson Matthew , Semakula Muhammed , Jang Hyeju , Mugabo Hassan , Magzari Ali , Blackmer Junhong Ma , Fattah Fanan , Niyonsenga Simon Pierre , Rwagasore Edson , Ruranga Charles , Remera Eric , Ngabonziza Jean Claude S. , Carenini Giuseppe , Nsanzimana Sabin
Published: January 2025

Community isolation of patients with communicable infectious diseases limits spread of pathogens but our understanding of isolated patients’ needs and challenges is incomplete. Rwanda deployed a digital health service nationally to assist public health clinicians to remotely monitor and support SARS-CoV-2 cases via their mobile phones using daily interactive short message service (SMS) check-ins. We aimed to assess the texting patterns and communicated topics to better understand patient experiences. We extracted data on all COVID-19 cases and exposed contacts who were enrolled in the WelTel text messaging program between March 18, 2020, and March 31, 2022, and linked demographic and clinical data from the national COVID-19 registry. A sample of the text conversation corpus was English-translated and labeled with topics of interest defined by medical experts. Multiple natural language processing (NLP) topic classification models were trained and compared using F1 scores. Best performing models were applied to classify unlabeled conversations. Total 33,081 isolated patients (mean age 33·9, range 0–100), 44% female, including 30,398 cases and 2,683 contacts) were registered in WelTel. Registered patients generated 12,119 interactive text conversations in Kinyarwanda (n = 8,183, 67%), English (n = 3,069, 25%) and other languages. Sufficiently trained large language models (LLMs) were unavailable for Kinyarwanda. Traditional machine learning (ML) models outperformed fine-tuned transformer architecture language models on the native untranslated language corpus, however, the reverse was observed of models trained on English-only data. The most frequently identified topics discussed included symptoms (69%), diagnostics (38%), social issues (19%), prevention (18%), healthcare logistics (16%), and treatment (8·5%). Education, advice, and triage on these topics were provided to patients. Interactive text messaging can be used to remotely support isolated patients in pandemics at scale. NLP can help evaluate the medical and social factors that affect isolated patients which could ultimately inform precision public health responses to future pandemics.
Ultrasound renal denervation in hypertensive patients: A systematic review and meta-analysis
Authors: Ramadhan Roy Novri , Rampengan Derren David Christian Homenta , Gunawan Felicia Angelica , Nathania  , Willyanto Sebastian Emmanuel , Yamada Hiroyuki , Thaha Mochammad , Suryantoro Satriyo Dwi , Empitu Maulana Antiyan
Published: January 2025

Introduction

Hypertension is the leading noncommunicable disease case affecting 1.28 billion individuals worldwide, with most cases located in low- and middle-income countries. While there are numerous techniques for treating mild to moderate hypertension, properly controlling severe or resistant hypertension poses substantial challenges. Ultrasound-based renal denervation (uRDN) has emerged as a promising non-pharmacological approach. This study aims to investigate the safety and efficacy of uRDN in hypertensive patients.

Methods

The literature search across PubMed, ScienceDirect, BMJ Journals, ProQuest, and Springer databases yielded 419 articles. A total of 395 articles were filtered, leading to 24 articles assessed for eligibility and overall analysis, which resulted in eight included studies for quantitative synthesis. Quality appraisal used RoB 2.0, while meta-analysis used RevMan 5.4.

Results

Our analysis results indicated significant improvements in 24-hour, daytime, and home ambulatory blood pressure measurements, favoring the uRDN over control. The mean difference (MD) for 24-hour measurements was -0.84 mmHg [95% CI -1.14, -0.55; p < 0.00001], for daytime measurements -1.27 mmHg [95% CI -1.59, -0.95; p < 0.00001], and for home measurements -1.98 mmHg [95% CI -2.32, -1.64; p < 0.00001], with moderate heterogeneity observed. Office ambulatory measurements also favored the uRDN with a significant MD of -1.51 mmHg [95% CI -1.91; -1.10; p < 0.00001]. Funnel plots revealed some outliers, indicating true heterogeneity among the studies.

Conclusion

uRDN was associated with a significant reduction (-2.32 to -0.10 mmHg) in blood pressure of hypertensive patients.
Improving early prediction of crop yield in Spanish olive groves using satellite imagery and machine learning
Authors: Ramos M. Isabel , Cubillas Juan J. , Córdoba Ruth M. , Ortega Lidia M.
Published: January 2025

In the production sector, the usefulness of predictive systems as a tool for management and decision-making is well known. In the agricultural sector, a correct economic balance of the farm depends on making the right decisions. For this purpose, having information in advance on crop yields is an extraordinary help. Numerous predictive models infer accurate crop yield data from aerobiological variables and pollen analysis; this is around spring, in the middle stage of the crop year, when planning and investments are already done. The aim of this study is to anticipate accurate crop yield data at an early stage of the cropping season. In the case of olive groves in Spain, this period is in February. This work is developed for an entire province, Jaen, belonging to the region of Andalusia, in Southern Spain. The methodology uses Machine Learning algorithms together with an exhaustive analysis of predictor variables. Temporal data come from public web services, such as spatial data infrastructures of some state agencies. The processing of the satellite imagery is carried out by the geospatial processing service Google Earth Engine. The result is the early prediction of kilograms of both olive crop and olive oil, eight months prior to the beginning of the first harvesting campaigns of the year, with an average absolute error of prediction better than 26%. The relevance of this work is the early availability of predicted crop yield data together with the multi-scale applicability of the predictive models. This makes this model a useful tool for all the agents involved in olive grove management. From farmers, to agricultural technicians, researchers and scientists dedicated to the study of the olive tree, to governmental institutions and agricultural associations that provide technical support, advice and regulation to ensure responsible practices and the long-term viability of the olive industry.
Trait and plasticity evolution under competition and mutualism in evolving pairwise yeast communities
Authors: Wang ShengPei , Agarwal Renuka , Segraves Kari A. , Althoff David M.
Published: January 2025

Although we have a good understanding of how phenotypic plasticity evolves in response to abiotic environments, we know comparatively less about responses to biotic interactions. We experimentally tested how competition and mutualism affected trait and plasticity evolution of pairwise communities of genetically modified brewer’s yeast. We quantified evolutionary changes in growth rate, resource use efficiency (RUE), and their plasticity in strains evolving alone, with a competitor, and with a mutualist. Compared to their ancestors, strains evolving alone had lower RUE and RUE plasticity. There was also an evolutionary tradeoff between changes in growth rate and RUE in strains evolving alone, suggesting selection for increased growth rate at the cost of efficiency. Strains evolving with a competitive partner had higher growth rates, slightly lower RUE, and a stronger tradeoff between growth rate and efficiency. In contrast, mutualism had opposite effects on trait evolution. Strains evolving with a mutualist had slightly lower growth rates, higher RUE, and a weak evolutionary tradeoff between growth rate and RUE. Despite their different effects on trait evolution, competition and mutualism had little effect on plasticity evolution for either trait, suggesting that abiotic factors could be more important than biotic factors in generating selection for plasticity.
State of the art modelling for the Black Sea ecosystem to support European policies
Authors: Serpetti Natalia , Piroddi Chiara , Akoglu Ekin , Garcia-Gorriz Elisa , Miladinova Svetla , Macias Diego
Published: January 2025

The Black Sea is affected by numerous anthropogenic pressures, such as eutrophication and pollution through coastal and river discharges, fisheries overexploitation, species invasions, and the impacts of climate change. Growing concerns regarding the cumulative effects of these pressures have necessitated the need for an ecosystem approach to assessing the state of this basin. In recent years, the European Commission-JRC has developed a scientific and modelling tool, the Blue2 Modelling Framework with the aim of exploring the consequences of EU management and policy options on marine ecosystems. This framework has been designed to provide information on specific ecological indicators set out in EU legislation. Here, we present the Blue2 framework for the Black Sea ecosystem. The model represented the mid-1990s’ conditions in the Black Sea ecosystem including trophic levels from primary producers to marine mammals and sea birds. The model simulations covered a period from 1995–2021. The results showed that gulls & cormorant seabirds, sprat, horse mackerel and mugilidae had structuring role in the food web. Fishing fleets had indirect negative impacts on marine mammals in addition to commercially exploited species. Analysis of the ecosystem indicators confirmed the overall temporal degradation of the Black Sea when comparing results with other Black Sea models, whilst the comparison with the Mediterranean Sea allowed us to identify comparable indicators between similar model structures. The spatial/temporal model successfully simulated the overall ongoing declining dynamics of the Black Sea ecosystem as the biomasses of the majority of the functional groups had significant observed decreasing trends during the simulation period. This model is the first attempt to represent the historical and current state of the Black Sea ecosystem spatially and temporally, serving as a reference baseline for evaluating policy scenarios and assisting policy makers in the evaluation of potential environmental impacts of management options.
Phytochemical analysis and biological activities of solvent extracts and silver nanoparticles obtained from Woodwardia unigemmata (Makino) Nakai
Authors: Shah Syed Ahsan , Gul Alia , Shah Ghulam Mujtaba , Wizrah Maha Saeed Ibrahim , Khalid Awais , Munir Mamoona , Maqbool Zainab , Aftab Arusa , Alrahili Mazen R. , Siddiqua Ayesha , Begum M. Yasmin
Published: January 2025

Multidrug resistant bacteria are causing health problems and economic burden worldwide; alternative treatment options such as natural products and nanoparticles have attained great attention recently. Therefore, we aimed to determine the phytochemicals, antibacterial potential, and anticancer activity of W. unigemmata. Extracts in different organic and inorganic solvents were prepared, silver nanoparticles were prepared using the green synthesis method. Phytochemicals and antioxidant activity was determined spectrophotometry, anticancer potential was determined against gastric cancer and normal gastric epithelial cells using CCK8 and colony formation assays W. unigemmata was found to have a significant enrichment of various phytochemicals including flavonoids, terpenoids, alkaloids, carotenoids, tannins, saponins, quinines, carbohydrates, phenols, coumarins and phlobatanins. Among them phenolics (5289.89 ± 112.67) had high enrichment followed by reducing sugar (851.53 ± 120.15), flavonoids (408.28 ± 20.26) and ascorbic acid (347.64 ± 16.32), respectively. The extracts prepared in organic solvents showed strong antibacterial activity against P. aeruginosa (chloroform, 13.66±0.88, ethyl acetate, 8.66±4.33, methyl alcohol, 13.33±1.66, N-hexane, 12.33±0.88) and S. aureus (chloroform, 15±0.57, ethyl acetate, 16.33±0.33, methyl alcohol, 17.66±0.33 and N-hexane, 16.33±0.33). Aqueously prepared AgNPs showed remarkable activity against P. aeruginosa follwed by E. coli, 17.66 ± 1.85, S. aureus, 16.00 ± 1.73, K. pneumoniae, 14.33 ± 1.20, respectively. The ethanolic extracts (500 μg, 1000 μg, 2000 μg) of the W. unigemmata were found to have cytotoxicity against both gastric cancer (AGS and SGC7901) and normal cell lines (GES-1); a significant cellular proliferation arrest was observed.

These results suggest that W. Unigemmata contains numerous bioactive phytochemicals and can be useful as a drug against MDR bacterial strains. These biomolecules covering AgNPs may enhance their biological activities, which can be employed in the treatment of various microbial infections.
Altered microbiome and metabolome profiling in fearful companion dogs: An exploratory study
Authors: Sacchettino Luigi , Costanzo Michele , Veneruso Iolanda , D’Argenio Valeria , Mayer Maria , Napolitano Francesco , d’Angelo Danila
Published: January 2025

Behavioral dysfunctions in dogs represent one of the main social concerns, since they can endanger animals and human-dog relationship. Together with the trigger stimulus (human, animal, place, scent, auditory stimuli, objects), dogs can experience stressful conditions, either in multiple settings or unique situations, more often turning into generalized fear. Such a dysfunctional behavior can be associated with genetic susceptibility, environmental factors, traumatic experiences, and medical conditions. The available therapy, based on behavior approaches, environmental management, and neurochemical manipulation, through nutrition, supplements, medicines, and pheromones, represent the mainstays of the treatments currently accessible. Growing evidence in humans and animals highlight the importance of the gut-brain axis in the modulation of the brain physiology and behavior as well. Here, taking advantage of the next generation sequencing approach, we sought to investigate the potential connection between gut microbiota and microbiome in dogs suffering from generalized fear (n = 8), when compared to healthy subjects (n = 8), who all lived in different families. Faecal microbiota evaluation showed a differential abundance of taxa related to Proteobacteria and Firmicutes Phyla, between case and control dogs. Moreover, serum metabolomics documented significant alterations of molecules associated to GABA and glutamate neurotransmission in the patients, as well as bile acids metabolism. Overall, our preliminary and integrated investigations highlighted an intriguing role for the microbiome-metabolome network, allowing to further unveil the potential pathophysiology of relational issues in companion animals and paving the way for more effective therapeutical approaches.
Assessing changing baleen whale distributions and reported incidents relative to vessel activity in the Northwest Atlantic
Authors: Solway Hannah , Worm Boris , Wimmer Tonya , Tittensor Derek P.
Published: January 2025

Baleen whales are among the largest marine megafauna, and while mostly well-protected from direct exploitation, they are increasingly affected by vessel traffic, interactions with fisheries, and climate change. Adverse interactions, notably vessel strikes and fishing gear entanglement, often result in distress, injury, or death for these animals. In Atlantic Canadian waters, such negative interactions or ‘incidents’ are consistently reported to marine animal response organizations but have not yet been analyzed relative to the spatial distribution of whales and vessels. Using a database of 483,003 whale sightings, 1,110 incident reports, and 82 million hours of maritime vessel activity, we conducted a spatiotemporal vulnerability analysis for all six baleen whale species occurring in the Northwest Atlantic Ocean by developing an ensemble of habitat-suitability models. The relative spatial risk of vessel-induced incidents was assessed for present (1985–2015) and projected near-future (2035–2055) distributions of baleen whales. Areas of high habitat suitability for multiple baleen whale species were intrinsically linked to sea surface temperature and salinity, with multispecies hotspots identified in the Bay of Fundy, Scotian Shelf, Laurentian Channel, Flemish Cap, and Gulf of St. Lawrence. Present-day model projections were independently evaluated using a separate database of acoustic detections and found to align well. Regions of high relative incident risk were projected close to densely inhabited regions, principal maritime routes, and major fishing grounds, in general coinciding with reported incident hotspots. While some high-risk regions already benefit from mitigation strategies aimed at protecting North Atlantic Right Whales, our analysis highlights the importance of considering risks to multiple species, both in the present day and under continued environmental change.
3D fluorescence staining and confocal imaging of low amount of intestinal organoids (enteroids): Protocol accessible to all
Authors: Toulehohoun Ami Gloria , Bouzin Caroline , Daumerie Aurélie , Maccioni Luca , Stärkel Peter
Published: January 2025

The emerging field of 3D organ modeling encounters several imaging issues in particular related to antigen retrieval and sample loss during staining processes. Due to their compact shape, several antibodies fail to penetrate intact organoids or spheroids. Histology of organoids can be approached by paraffin inclusion and sectioning at 5 μm as performed for biopsies. However, to fully understand organoid behavior, including cellular organization, extracellular matrix structure, and their response to treatments, 3D imaging is essential. Here we propose an easy workflow allowing (1) immunostaining with a HIER step, (2) preservation of the intact shape of the organoids, (3) sample immobilization in a focal plane reachable for high resolution/short working distance lenses, and (4) minimizing the risk of loss of precious material.
Do higher educated people feel happier?—Evidence of Han and minority nationalities from China
Authors: Wang Yuanyuan , Hu Zhenyi , Yuan Jiameng , Zhang Kun
Published: January 2025

Based on the data of China General Social Survey (CGSS), this study adopts empirical analysis method to explore the impact of education on residents’ subjective well-being and its differentiated mechanism in different ethnic groups. The results show that, first of all, education significantly improves residents’ subjective well-being, and the conclusion is still robust after controlling for endogenous problems. Secondly, compared with Han nationality, education has a more significant effect on the subjective well-being of ethnic minority residents. Finally, by comparing the internal mechanism of education on the subjective well-being of Han and ethnic minority residents, the research finds that education mainly improves subjective well-being by improving residents’ relative income level and enhancing their social class identification, in which the intermediary effect of income is particularly prominent. However, in the Han population, education may weaken the sense of fairness, and thus reduce happiness to some extent; This phenomenon has not been verified in ethnic minority groups. This study not only expands the literature on the relationship between education and subjective well-being, but also has important policy implications, providing a strong empirical basis for formulating more accurate education policies, improving the happiness of ethnic minority residents, and enhancing national cohesion.
Nasal microbiota predictors for methicillin resistant Staphylococcus colonization in critically ill children
Authors: Zani Kathleen , Hobeika Joseph , Sun Yilun , Kohler Christina , Cherian Anju , Fields Trinity , Jia Qidong , Tang Li , Hysmith Nicholas D. , Margolis Elisa B.
Published: January 2025

Background

Surveillance cultures to identify patients colonized with methicillin-resistant Staphylococcus aureus (MRSA) is recommended at pediatric intensive care unit (PICU) admission but doesn’t capture other methicillin-resistant Staphylococcus and is resource intensive. We determined the prevalence and identified nasal microbiome predictors for methicillin-resistant Staphylococcus colonization at the time of PICU admission.

Study design

A prospective cohort study was performed in a 20-bed pediatric intensive care unit (PICU) between 2020–2021. Anterior nares nasal swabs processed for MRSA culture, nasal microbiome and mecA+ qPCR were obtained within first five days after PICU admission. Predictive values of methicillin-resistant Staphylococcus carriage on symptoms of infection and for nasal microbiome attributes were calculated.

Results

A total of 5 (8.0%) of 62 patients had a nares culture positive for MRSA and 22 (35.5%) of 63 patients had methicillin-resistant Staphylococcus (MRSA or methicillin-resistant coagulase-negative Staphylococci). In univariate analysis, carriage with MRSA or MRCoNS was associated with having a fever during PICU stay. Colonization with a distinct set of microbes (including Haemophilus, Streptococcus, Prevotella and Corynebacterium sp.) was predictive of having methicillin-resistant Staphylococcus colonization.

Conclusions

Carriage with methicillin-resistant Staphylococcus may lead to transmission in critically ill pediatric patients. Carriage of particular nasal microbes appears to facilitate colonization with methicillin-resistant Staphylococcus.
Gene expression analysis reveals mir-29 as a linker regulatory molecule among rheumatoid arthritis, inflammatory bowel disease, and dementia: Insights from systems biology approach
Authors: S. Devi Soorya Narayana , Sundararajan Vino
Published: January 2025

Background

Rheumatoid arthritis (RA) is a degenerative autoimmune disease, often managed through symptomatic treatment. The co-occurrence of the reported extra-articular comorbidities such as inflammatory bowel disease (IBD), and dementia may complicate the pathology of the disease as well as the treatment strategies. Therefore, in our study, we aim to elucidate the key genes, and regulatory elements implicated in the progression and association of these diseases, thereby highlighting the linked potential therapeutic targets.

Methodology

Ten microarray datasets each for RA, and IBD, and nine datasets for dementia were obtained from Gene Expression Omnibus. We identified common differentially expressed genes (DEGs) and constructed a gene-gene interaction network. Subsequently, topology analysis for hub gene identification, cluster and functional enrichment, and regulatory network analysis were performed. The hub genes were then validated using independent microarray datasets from Gene Expression Omnibus.

Results

A total of 198 common DEGs were identified from which CD44, FN1, IGF1, COL1A2, and POSTN were identified as the hub genes in our study. These hub genes were mostly enriched in significant processes and pathways like tissue development, collagen binding, cell adhesion, regulation of ERK1/2 cascade, PI3K-AKT signaling, and cell surface receptor signaling. Key transcription factors TWIST2, CEBPA, EP300, HDAC1, HDAC2, NFKB1, RELA, TWIST1, and YY1 along with the miRNA hsa-miR-29 were found to regulate the expression of the hub genes significantly. Among these regulatory molecules, miR-29 emerged as a significant linker molecule, bridging the molecular mechanisms of RA, IBD, and dementia. Validation of our hub genes demonstrated a similar expression trend in the independent datasets used for our study.

Conclusion

Our study underscores the significant role of miR-29 in modulating the expression of hub genes and the associated transcription factors, which are crucial in the comorbidity status of RA, dementia, and IBD. This regulatory mechanism highlights miR-29 as a key player in the pathogenesis of these comorbid diseases.
Integrating life cycle assessment into supply chain optimization
Authors: Hülagü Selin , Dullaert Wout , Eruguz A. Sena , Heijungs Reinout , Inghels Dirk
Published: January 2025

Integrating Supply Chain Optimization (SCO) with Life Cycle Assessment (LCA) is essential for creating supply chains that are both economically efficient and environmentally sustainable. While SCO focuses on optimizing network structures and decisions related to product and service delivery, LCA systematically assesses the environmental impacts across the entire supply chain. The existing literature treats SCO and LCA as separate, sequential steps, often leading to inconsistencies in scope and challenges in data transfer and rescaling. Our research presents a novel Supply Chain Life Cycle Optimization (SCLCO) model that integrates SCO and LCA. Our SCLCO model is based on LCA data structures, incorporates multi-time period, closed-loop SCO decisions (e.g. reverse chain management, inventory control, network design), and is capable of considering the three pillars of sustainability: environmental, economic, and social. It includes harmonizing principles, terminology, and notation, thereby bridging the gap between the SCO and LCA communities through a generalized formulation. Computational experiments on a selected SCO model from Operations Research literature validate the SCLCO and demonstrate its effectiveness in providing valuable insights to both SCO and LCA practitioners and researchers. The results emphasize that the simultaneous execution of SCO and LCA in SCLCO minimizes the risk of overlooking decision impacts and facilitates data transfer from existing LCA databases.
Impact of hysterectomy on opioid use in patients with adenomyosis: A nationwide register study
Authors: Brunes Malin , Jonsdottir Gudny , Ek Marion , Kallner Helena Kopp , Hasselrot Klara
Published: January 2025

Introduction

Dysmenorrhea and heavy menstrual bleeding are the most common symptoms in adenomyosis, in addition to infertility and chronic pelvic pain. Hysterectomy is a common treatment for adenomyosis symptoms with curative effect on heavy menstrual bleeding but with less studied effects on pain reduction.

Material and methods

This is a nationwide retrospective register-based cohort study including all hysterectomized patients with pathology-verified adenomyosis between 1 January 2012 and 31 December 2015 with a long-term follow-up three years pre- and three years postoperatively. Two national registers were linked in order to describe the primary outcome of proportion with use of opioids among hysterectomized patients with and without adenomyosis pre- and postoperatively. Logistic and multinomial regression models were used.

Results

A total of 2,228 (15%) patients had pathology-verified adenomyosis. Overall opioid use was 18.6% and 21.1% three years before and three years after surgery, respectively. Results showed a significantly increased risk of opioid use three years after hysterectomy in patients with preoperative use of opioids and antidepressants (adjusted Odds Ratio (aOR) 5.7, 95% Confidence Interval (CI) 4.5–7.2 and aOR 1.4, 95% CI 1.1–1.8). The risk of needing long-term opioids was higher among patients with smaller uteri (<300g, aOR 2.8, 95% CI 1.7–4.7) compared to women with uterine sizes ≥600g.

Conclusions

Hysterectomy does not reduce opioid use among adenomyosis patients in long-term follow-up, although the subjective reduction of pain was not investigated in this study. Women with preoperative use of opioids/antidepressants and uterine size <300g are at increased risk for chronic opioid use.
Spatiotemporal evolution of hedging effects in Asia-Pacific countries amid Sino-US competition: Insights from massive event data
Authors: Hu Qiyue , Yuan Lihua , Liu Bin
Published: January 2025

Facing the pressure of Sino-US strategic competition, countries in the Asia-Pacific region often adopt hedging strategies to minimize risk and protect their interests. If implemented, these strategies could impact relationships between countries and lead to political instability. Owing to a lack of theoretical evaluation frameworks and methods, few studies have examined the implementation effects of hedging strategies adopted by Asia-Pacific countries amid Sino-US competition. This study proposes a novel four-quadrant evaluation theoretical framework, and constructs a Geopolitical Relation Index and a Comparative Relation Index based on the Global Database of Events, Language, and Tone massive event data. Since 2000, the effects of hedging strategies in 19 Asia-Pacific countries against China and the US have been dynamically quantified. The research reveals that Asia-Pacific countries’ dynamic performances over 24 years can be categorized into three groups: significantly closer to China, significantly closer to the US, and swinging. Since implementing the Belt and Road Initiative, countries close to China have deepened their ties, while those aligned with the US have strengthened their ties. Asia-Pacific countries have demonstrated similar characteristics from Obama’s presidency to Biden’s presidency. The results contribute to the dynamic assessment and ongoing monitoring of the execution effects of Asia-Pacific countries’ diplomatic strategies towards China and the US, offering valuable insights for timely refinement of their foreign policies.
New oscillation criteria for third order nonlinear
functional differential equations
Authors: Graef John , Grace Said , Chhatria Gokula
Published: January 2025

The authors consider the general third order functional
differential equation

(

a

2

(

ν

)

[

(

a

1

(

ν

)

(

x
′

(

ν

)

)

α

1

)

′

]

α

2

)

′

+
q
(

ν

)

x

β

(

τ

(

ν

)
)
=
0
,

ν

≥

ν

0

,

and obtain sufficient conditions for the oscillation of all
solutions.
It is important to note that

α

i

for

i
=
1
,
2

, and

β

are somewhat independent of each other. The results obtained are
illustrated with examples.
Normalized solutions for a fractional coupled critical
Hartree system
Authors: Deng Shengbing , Luo Wenshan
Published: January 2025

We consider the existence of normalized solutions for a
fractional
coupled Hartree system, with the upper critical
exponent in the
sense of the Hardy-Littelwood-Sobolev inequality.
Particularly, in
an

L
2

-subcritical regime or an

L
2

-supercritical regime, we establish the existence of positive
normalized solutions for the two cases, respectively. Furthermore,
we prove the nonexistence of positive normalized solutions, under
the nonlinearities satisfying the Sobolev critical growth.
Effect of UV-radiation on IR, BR, and SBR elastomers FT-IR spectra
Authors: Ondrušová Darina , Pajtášová Mariana , Ďurišová Silvia , Tomasz Klepka Tomasz Klepka , Labaj Ivan , Šanobová Mária , Lokšíková Simona
Published: January 2025

The effect of UV radiation on infrared spectra (FT-IR) and mass change of elastomers (IR, BR, SBR) was studied. It was found that with the extension of the UV radiation time the intensity of bands originating from hydroxyl and carbonyl groups increased. Carbonyl groups were identified in SBR after 30 h of exposure, while in IR and BR after 18 h. It was shown that SBR was characterized by the highest resistance to UV radiation.
Return to a standard diet after a high-calorie diet improves metabolic indexes and reactivity of the rat aorta
Authors: Pankova M. N.
Published: January 2025

BACKGROUND: Solution to the important problem of reducing cardiovascular diseases and the risk of death associated with metabolic syndrome (MS) depends on our understanding of mechanisms of different influences preventing its development and change of our lifestyle in accordance to this knowledge. However, the question remains as to how reversible the disorders resulting from the development of MS, in particular, those induced by a high-calorie diet, are. There is a lot of research work of functional disturbance during a diet, but information about what happens after diet is extremely scarce. The possibility of restoring impaired functions is not only of theoretical, but also of great practical interest.AIM: To evaluate changes in the metabolic state and reactivity of the rat aorta to the vasoconstrictor agent phenylephrine (PhE) when fed a high-calorie diet (CAF) for 6 weeks and after normalization of nutrition.MATERIALS AND METHODS: This study was performed on mature male Wistar rats, which were divided into a control group fed a standard diet (SD) and an experimental group fed a cafeteria diet (CAF). CAF and recovery period (Post-CAF) lasted 6 weeks each. At the end of each period, metabolic indexes were appreciated. The study of aortic reactivity was carried out on isolated vessels using wire myography. Statistical data processing was carried out using the GraphPad Prizm 8.0.1 program.RESULTS: The study showed that the use of CAF led to an increase in body weight and the amount of visceral fat (2 times) in experimental animals compared to controls. They had higher fasting blood levels of triglycerides 1.77±0.42 mM vs 0.70±0.16 mM and glucose 7.6±0.9 mM vs 4.7±0.73 mM , respectively, and the indicators obtained when performing a glucose tolerance test. During the Post-CAF period, a decrease in weight gain was observed in rats, especially at its beginning, and the indicators recorded at the end of the recovery period were not statistically different from those in the SD group. As a result of a study of aortic reactivity, data were obtained on an increase of vasoconstrictor responses to the action of PhE in the CAF group due to a decrease in the anticontractile effect of NO and the participation in this process of potassium channels blocked by TEA. After Post-CAF, restoration of the influence of NO and the contribution of voltage-gated and/ or Ca2+- activated K+ channels of smooth muscles was recorded, which ultimately leads to a return of aortic reactivity to the values same as in the SD group.CONCLUSION: The obtained data indicate that after normalization of nutrition the reversibility of metabolic disorders of carbohydrate and lipid metabolism and increased vasoconstriction of the aorta, recorded with the use of a cafeteria diet, occurs
Mineral disorders in patients with chronic liver disease. Part 1: epidemiology and pathophysiology
Authors: Gorbacheva A. M. , Bibik E. E. , Lavreniuk A. A. , Eremkina A. K. , Tikhonov I. N. , Mokrysheva N. G.
Published: January 2025

Chronic liver disease is a significant public health problem worldwide, and its consequences lead to the development of various mineral disorders, which occur in 75% of patients. Osteoporosis (up to 30% of patients) has the greatest clinical significance among the mineral disorders that develop in chronic liver disease. Fractures occur, according to different data, in 7-35% of patients. There are number of mechanisms influencing the state of mineral metabolism in chronic liver diseases: from the disturbance of vitamin D metabolism to the synthesis of pro-inflammatory cytokines and the function of intestinal microbiota. To date, these processes remain insufficiently studied: for example, aspects concerning the functioning of parathyroid glands in chronic liver diseases are not completely clear; there is no clear idea about the predominant processes in bone tissue (anti- or proresorptive). This determines the imperfection of prophylactic and therapeutic approaches in mineral disorders due to chronic liver diseases and the need for further research in this direction. The first part of this review focuses on the epidemiology and pathophysiology of mineral metabolism disorders in these conditions; the second part of the review will focus on current therapeutic approaches
Seasonal dynamics of 25-OH vitamin D and biogenic amines in the blood of apparently healthy men living in the city of Arkhangelsk
Authors: Alikina V. A. , Elfimova A. E. , Molodovskaya I. N. , Tipisova E. V. , Zyabisheva V. N.
Published: January 2025

BACKGROUND: The Arctic zone territories of the Russian Federation have the risk of developing 25-OH vitamin D deficiency, which is aggravated by low levels of insolation and nutrition low in vitamins and minerals. Along with low levels of insolation and reduced vitamin D concentrations during periods of minimal daylight hours, manifestations of seasonal affective disorder may occur, which is characterized by circadian dysregulation and monoaminergic functions of neurotransmitters (serotonin, dopamine, noradrenaline). The scientific challenge lies in estimating 25-OH vitamin D and biogenic amines sufficiency and detecting associative changes in 25-OH vitamin D and biogenic amines levels during various photoperiods of the year in the population of Arkhangelsk, as well as in further identification of typological variations in the intra-individual dynamics of the studied indicators depending on gender and daylight hours.

AIM. The purpose is to assess the seasonal sufficiency of vitamin D and biogenic amines for apparently healthy men of working age living in the city of Arkhangelsk.

METHODS. An analytical prospective uncontrolled study was conducted with the participation of 20 clinically healthy men from the city of Arkhangelsk (64°32’24.4’’N). Blood samples were collected every season (March, June, September, December) during the year with subsequent determination of the concentrations of vitamin D, serotonin, dopamine, adrenaline and noradrenaline in the blood. Statistical analysis of endocrine parameters was performed using the Wilcoxon rank test with the Bonferroni correction.

RESULT: According to the revealed annual dynamics, the concentration of 25-OH vitamin D in the blood of men who live in the city of Arkhangelsk reached a minimum level during an increase in daylight hours (March), followed by an increase in vitamin concentration in summer (June) and a maximum concentration level during a decrease in daylight hours (September). The largest percentage of people (45%) with insufficient (below 30 ng /ml) vitamin D concentration in the blood is noted during the period of increasing daylight (March), while in summer and autumn this percentage decreases to 10, and in winter no insufficient concentrations of vitamin D are detected.

CONCLUSION: In terms of vitamin D concentration in the blood of men, the period of increase in daylight hours (March) is the most critical season, whereas the period of decrease in daylight hours (September) is a more favourable one. Seasonal dynamics of serotonin concentrations were associated with changes in vitamin D levels during the year. Seasonal variations of dopamine, adrenaline and noradrenaline concentrations were similar to each other and different from the annual dynamics of vitamin D concentration in the blood.
Common fixed-point theorems on complex partial b- metric space
Authors: Kumar Dwivedi Dr. Pradeep
Published: January 2025

In this paper, we establish some unique common fixed-point theorems for two pairs of weakly compatible mappings in complex partial b-metric space which generalize and improves several well- known common fixed point results in partial b-metric space.
Telaah Hermeneutika Kritis terhadap Femisida dalam Perspektif Al-Qur'an serta Relevansinya terhadapa Pendidikan Agama Islam
Authors: Abror Indal , Al-Faiz Muhammad Rabbany Tarman  , Tri Wulandari
Published: January 2025

Gender injustice that seems to be legitimized by normative texts is seriously challenged by problems of interpretation. This research is a library research and qualitative. The author focuses on Femicide in the Perspective of the Qur'an: A Critical Hermeneutic Analysis and its Relevance to Islamic Religious Education. Femicide is a criminal act of sadistic murder based on hatred of women committed by men. In the Qur'anic perspective, it is substantially described in four verses, namely QS. al-An'am 6: 137, QS. At-Takwir 81: 8, QS. An-Nahl 16: 59 and QS. This is a historical fact as documented in several Prophetic traditions. Femicide behavior in pre-Islamic times should be reinterpreted according to the times. The word can be understood to mean sadistic behavior such as being mutilated, abused, burned, crushed, and so on. Femicide is relevant to discuss because PAI plays an important role in shaping human values and attitudes. PAI has the potential to be an effective tool in instilling aspects of humanity, justice, and respect for human rights, including women's rights.
Uczniowie z doświadczeniem migracji w polskich szkołach oczyma przyszłych polonistów – od wyzwań do szukania nowych rozwiązań
Authors: Wrześniewska-Pietrzak Marta
Published: January 2025

Artykuł przedstawia problem kształcenia nauczycieli polonistów, którzy w swojej pracy zawodowej nauczają uczniów z doświadczeniem migracyjnym. Autorka przedstawia dane dotyczące zwiększającej się liczby uczniów z takim doświadczeniem w polskich szkołach, które były podstawą badań ankietowych prowadzonych wśród studentów polonistyki. Otrzymane wyniki jednoznacznie wskazują, że ważnym współcześnie zadaniem jest rozwinięcie u przyszłych polonistów (a także nauczycieli innych przedmiotów szkolnych) kompetencji, które będą mogli wykorzystać w pracy lekcyjnej z właśnie uczniami z doświadczeniem migracyjnym. Autorka stara się na te potrzeby odpowiedzieć, prezentując w dalszej części artykułu propozycje warsztatów i działań, które pozwalają studentom filologii polskiej i zarazem członkom Koła Naukowego Polonistów Co-lektor poznać i zrozumieć nową dla nich sytuację pracy z uczniem obcokrajowcem. Przedstawione warsztaty stanowią jedną z propozycji uzupełniającą kształcenie przyszłych nauczycieli polonistów (i nie tylko).