bluuebunny/crossref_metadata_2025 huggingface dataset:
El Aprendizaje de las Teorías Económicas a Través del Avance en la Currícula del Estudiante de Nivel Superior: Un Análisis Matemático para el Caso de la UAZ

Authors: Hernández Ortiz Marlen , Moreno Mejía Juan Nicolas , Ortiz Medina Imelda , Plata Pérez Pedro
Published: January 2023

El objetivo de este trabajo es realizar un análisis matemático respecto al aprendizaje de las teorías económicas que adquieren los estudiantes de la Licenciatura en Economía de la Universidad Autónoma de Zacatecas. Se aplicaron dos encuestas a estudiantes de diferentes niveles. El modelo de regresión logística binomial corrobora el resultado exploratorio y ANOVA, presentando contradicciones en el dominio de las teorías económicas cada vez más marcadas en estudiantes de niveles avanzados. Por lo tanto, se concluye que la aplicación de este análisis matemático podría aportar al diagnóstico para reflexión en la enseñanza-aprendizaje a nivel superior de carreras en economía y prevenir problemáticas en el desarrollo económico basadas en tomas de decisiones de profesionistas en esta área.
Como deve ser feita a avaliação de competências na residência médica em psiquiatria? Análise de quatro modelos e perspectivas para o Brasil
Authors: Baldaçara Leonardo Rodrigo , Generoso Marcelo Bruno , Sanches Marsal , Fidalgo Thiago Marques , Passos Ives Cavalcante , Uchida Ricardo Riyoiti , Shiozawa Pedro , Pedreira Paulo Geovanny , Silva Antônio Geraldo
Published: January 2023

A nova matriz de competências para os programas de residência médica em psiquiatria no Brasil, publicada em 6 de julho de 2021, traz um aprofundamento maior das habilidades a serem atingidas e amplia o horizonte de possibilidades de processos de ensino e aprendizagem teórica e prática. Entretanto, essa nova matriz de competências para a Residência Médica em Psiquiatria e respectivas áreas de atuação deixou uma lacuna exposta na legislação: Qual a melhor forma de avaliar as competências nos futuros especialistas durante seu treinamento? Visto que ainda não há legislação, nem consenso sobre o assunto, propomos a discussão de modelos de quatro locais do mundo que passaram por processos semelhantes nas últimas décadas, e que obtiveram bons resultados. Assim, o objetivo deste artigo é analisar esses modelos de avaliação de competências em residências de psiquiatria e fazer futuras propostas para o Brasil.
Features of legal procedures in the consideration of disputes related to contractual relations
Authors: Абдулин Руслан Робертович
Published: January 2023

The subject of the study is the peculiarities of legal procedures in the consideration of disputes related to contractual relations. The author of the article, by analyzing and summarizing scientific materials, materials of judicial practice, comes to the conclusion that in recent years, in the consideration of disputes related to contractual relations, the search for alternative ways to resolve emerging conflicts has been actualized. The author notes that legal procedures in the implementation of reconciliation of the parties in pre-trial, judicial and other alternative methods of dispute settlement are contractual in nature, that is, contractual legal procedures are used to settle a dispute (conflict) at any stage of contractual relations, which is not typical for other types of civil relations. Meanwhile, from the standpoint of a functional approach, extrajudicial, judicial and other methods of protecting the rights of participants in contractual relations can act as an effective tool for resolving conflicts arising between the parties. In the work, the author creatively used general scientific and private scientific methods in cognitively significant unity and in a complex combination, including: analysis and synthesis, abstraction, system-structural, comparative legal, etc. The scientific novelty of the research consists in the fact that the article is a comprehensive study that examines the regulatory and security functions provided to the parties in contractual relations aimed at establishing (arising) a contractual legal relationship, changing the content and termination of contractual relations, changing the subject matter of the contract, recognizing and confirming the right, as well as eliminating disputability (conflict) in contractual relations. The key to this maxim is that the parties, as carriers of a subjective right or legal obligation, in the event of a dispute (conflict), have the opportunity to choose the method provided for by law or a reasonable model of behavior for its settlement, as well as the procedure for its implementation.
Legal basis of the Supreme Council of Magistracy of the Tunisian Republic and its evolution
Authors: Solovyev Andrey  Aleksandrovich
Published: January 2023

The subject of this work is the study of the legal foundations of the activities of the Supreme Council of Magistracy of the Tunisian Republic, which is the highest body of the judicial community of the country. The author dwells on the key normative legal acts regulating the foundations of the legal status of the Supreme Council of Magistracy as a constitutional body, examines its structure, composition and competence. Special attention is paid to the place of the Supreme Council of Magistracy in the political system and the evolution of this body in connection with the crisis of 2010-2011 (the jasmine revolution), reflecting the most difficult compromises between political elites, as well as emerging disputes about competence between different branches of government of the country. During the research, the author used various methods of scientific cognition, both general: analysis, synthesis, logical and structural-functional, and special legal: formal legal, legal modeling method and comparative legal. The novelty of the research lies in the fact that the author for the first time in domestic legal science conducted a comparative study of the legal foundations of the activities of the Supreme Council of Magistracy of the Tunisian Republics, and also considered the evolution of this body in the context of a political crisis. The author comes to the conclusion that the evolution of the legal status of the judicial community of Tunisia is directly related to changes in the political system of this country, is very difficult and is currently far from complete.
The Mechanism of Subordinate Individual Legal Regulation of Crime Prevention Activities
Authors: Zaitseva Olesya Viktorovna , Dekhtyar' Ivan Nikolaevich
Published: January 2023

The study is devoted to the scientific analysis of the elements of the mechanism of subordinate individual legal regulation of activities to ensure the criminological security, in order to determine the conceptual foundations of the scientific understanding of this mechanism. The work was carried out on the basis of an interregional empirical study, which includes: a case study of acts of exercising rights and obligations in the field of crime prevention, interviewing law enforcement officers, as well as a content analysis of court decisions on administrative claims on appealing actions (inaction) and decisions of crime prevention subjects. The relevance of the topic is evidenced by the presence of problems of law enforcement due to shortcomings of regulatory legal acts regulating the activities for the prevention of offenses. The paper contains proposals for improving legislation in the aspect of individual preventive legal regulation. For the first time in criminology, a systematic analysis of the structural elements of the mechanism of subordinate individual legal regulation of crime prevention activities was carried out. The authors came to the conclusion that these should include: the object and subject of individual legal regulation; legal fact; method of individual legal regulation; technologies of regulatory law enforcement; individual legal means. New data have been obtained on criminological law enforcement technologies, in particular, on the use of mediation technology in preventive activities. The paper contains proposals for improving legislation in the aspect of individual preventive legal regulation.
The Russian Orthodox Church and the School: View through the Century
Authors: Iskhakova Rezeda Rifovna , Kolcherin Aleksei Sergeevich
Published: January 2023

In the modern educational space, the task of forming a civic personality as a result of the educational process is invariably relevant. The study of the historical experience of the 19th century shows that during this period there was a model of the educational process, the purpose of which was the formation of personality, its further socialization in accordance with a given place in hierarchically and class-organized Russian society. Orthodoxy and the Church played a decisive role. The article analyzes the main stages of interaction and mutual influence of the Russian Orthodox Church and the Ministry of Public Education in the field of formation of primary public schools. Conclusions are drawn that the internal policy of the government and the social movement in the country had a significant impact on public education. The leading discipline of the elementary folk school was the Law of God, the article reveals its place in the educational process. In the first half of the 19th century. The ROC became an important factor in the formation of a mass primary school, during the period of liberal reforms, the ROC weakened its position under the influence of a number of factors, including as a result of the appearance of the zemstvo and city schools. In 1880, a network of CPSH was created, which is a notable phenomenon and has had a significant impact on the development of education in the country.
Civilizational Foundations of Socio-Humanitarian Criteria for Evaluating Technological Innovations
Authors: Malakhova Elena Vladimirovna
Published: January 2023

The paper states that the civilizational foundations of socio–humanitarian criteria for evaluating technological innovations are, first of all, the value-normative systems of each individual civilization, and their modification inevitably either leads to a civilizational crisis, or is its consequence. Such crises themselves are considered not so much from the standpoint of their assessment (positive or negative), but based on ideas about their systemic nature – as a kind of an error in the functioning of the system, occurring either from its insufficient ability to adequately respond to external challenges, or from inconsistency in the pace and direction of development of its individual parts. In this article, the civilizational foundations on which the criteria for evaluating scientific and technical innovations are based on the following considerations: 1) the idea that modern civilization belongs precisely to the technogenic type, based on the works of V. S. Stepin; 2) the methodology of studying civilization as an autopoietic recursive system. According to the conclusions of the article, the modern technogenic civilization does not have the fullness of the grounds necessary for the formation of a consistent holistic system of socio-humanitarian criteria for evaluating technological innovations, however, such grounds may arise provided that the current value and world outlook crisis is overcome by eliminating the contradiction between the heuristic and teleological parts of the existing worldview.
Рhenomenon of Fantasy as a Form of Human Consciousness
Authors: Volkova Vera , Kamin Andrey
Published: January 2023

The article deals with the problem of fantasy as a form of consciousness. Ideas about consciousness change along with ideas about human nature. One form of the existence of consciousness is fantasy. Fantasy becomes a part of an anthropological study project about human existence as a reality of dominance of integrative knowledge. The era of conceptualization forms a request for awareness of a priori grounds for figurative perception of information and its living as an object in a fantasy form of consciousness. A feature of fantasy is that in the imagination there is a translation from perception into a generalized transcendental representation by creating a chain of associations, a drawing, a narrative. Non-linear description of the feelings and thoughts of a person in the epoch of romanticism, feeling surpasses intelligence. The formation of fantasy states of consciousness is associated with overcoming mirror reflection and getting into the noumenal world in higher dimensions, similar to mathematics and physics. External situation turns out to be a surface hiding fantasy as a dimension of human creative potential. Modern discussions of the reality of fantasy oppose it as a special form of reality, equal in its properties to the mind. Fantasy is the source of human experience of his being, embodied conceptually in the process of imaging. Imaginative cognition conceptually connects the experience of previous generations preserved in images with experiences in one's own life and the lives of others. As a source of creativity, fantasy extends to scientific knowledge, creating syntheses of different sciences
O DIREITO À ISONOMIA RACIAL NAS ABORDAGENS POLICIAIS: ANÁLISE JURÍDICA DO VIÉS RACIAL NA LETALIDADE POLICIAL NO BRASIL, EM 2020
Authors: Santos Débora Freitas dos , Ferreira Kennedy Rangel , Ferreira Hugo Luís Pena
Published: January 2023

Homicídios cometidos por policiais que vitimaram pessoas negras como George Floyd nos EUA, em 2020, e Genivaldo Santos, no Brasil, em 2022, apontam para a relevância do tema do direito à isonomia racial nas abordagens policiais. O presente artigo objetiva analisar a isonomia racial em abordagens policiais durante o ano de 2020 no Brasil. Aplicando a metodologia proposta pela Análise Jurídica da Política Econômica (AJPE), consistente na Análise Posicional, busca-se, por meio de indicadores relativos à letalidade policial, estratificados segundo raça/cor, conferir expressão quantitativa ao grau de viés racial em referida letalidade, no recorte proposto para a pesquisa. Para essa finalidade, o texto, primeiramente, delineia as características gerais de referida Análise Posicional da AJPE e apresenta uma proposta de sua aplicação para a temática do viés racial nas abordagens policiais no Brasil em 2020. Em seguida, apresenta resultados e os discute mediante a centralidade da noção de racismo estrutural, tendo por principais referenciais teóricos as contribuições de Silvio de Almeida e Adilson Moreira. A principal constatação alcançada foi de que a distância entre a proporção de negros e brancos mortos em decorrência de abordagens policiais, de um lado, e a proporção de negros e brancos na população em geral, de outro, foi da ordem de 48% para o ano de 2020, de modo a apontar que a letalidade policial observada nos dados compreendidos no recorte da pesquisa apresentou acentuado viés racial em desfavor de negros no Brasil. Em contraste com o plano formal de afirmação de um direito à isonomia racial, o artigo propõe interpretar os resultados como consubstanciando, no plano empírico, uma caracterização de um direito da discriminação racial nas abordagens policiais.
JULGAMENTO DO TEMA REPETITIVO 1018 PELO SUPERIOR TRIBUNAL DE JUSTIÇA
Authors: Massaro Mabtum Matheus , Caloche Sinara Lacerda Andrade , Pereira Nadia Carolina Martins
Published: January 2023

O presente estudo tem por escopo analisar o entendimento proferido pelo Superior Tribunal de Justiça no julgamento do Tema Repetitivo 1018 e a sua compatibilidade com os direitos da personalidade dos contribuintes. A tese firmada preceitua que o segurado tem direito de opção pelo benefício mais vantajoso concedido administrativamente, no curso da ação judicial em que se reconheceu benefício menos vantajoso e, concomitantemente, à execução das parcelas do benefício reconhecido na via judicial. Por se tratar de um julgamento realizado em junho de 2022, o seu estudo é extremamente importante e relevante cientificamente, podendo, inclusive, facilitar o entendimento dos avanços ou retrocessos da matéria no futuro próximo. O trabalho será desenvolvido por meio do método hipotético dedutivo, que consiste na pesquisa de obras doutrinárias, de artigos científicos, de legislação nacional e internacional que sejam pertinentes, na análise da jurisprudência, de documentos eletrônicos e dos dados estatísticos, retirados das bases de dados EBSCO, SSRN e Google Acadêmico.
A PARTICIPAÇÃO DAS MULHERES EM POLÍTICAS HÍDRICAS NO MUNICÍPIO DE OURO PRETO/MG
Authors: Matilde Resende Rosa Alexsandra , Guarda Vera Lúcia de Miranda , Alves Kerley dos Santos
Published: January 2023

Embora haja um expressivo número de normas jurídicas com o objetivo de combater a desigualdade em razão de gênero em todos os setores, as desigualdades persistem, o que ocorre também na gestão da água. Para preencher essa lacuna, a participação das mulheres nos conselhos e nas tomadas de decisões em relação aos recursos hídricos é uma das principais formas de garantia de acesso à água de forma mais igualitária. A participação delas possibilita também o empoderamento, proporcionando-lhes maior possibilidade de exercer poder e cidadania no espaço público, bem como uma maior legitimidade das normas jurídicas e maior eficácia das políticas públicas. Nesse trabalho foi realizado uma pesquisa de campo com conselheiros/as e trabalhadores/as que atuam na gestão da água em Ouro Preto/MG. Os dados foram coletados por meio de entrevistas e analisados. As análises dos dados apontaram a necessidade do aumento da participação das mulheres nas organizações e conselhos, tanto em número, quanto também, na ocupação de postos responsáveis pelas tomadas de decisões. A luta pela superação das diferenças, não se trata de uma luta exclusiva das mulheres, mas também dos homens, coautores e construtores das transformações sociais.
Aplicações endodônticas e periodontais da ozonioterapia
Authors: Salustiano Kamila Christina Souza , Silva Amandha Bikila , Mourão Warlan Lúcio Conceição , Fonseca Tiago Silva da
Published: January 2023

Objetivo: Realizar uma revisão narrativa da literatura sobre as aplicações do ozônio na Odontologia, enfatizando suas utilizações em Endodontia e em Periodontia. Revisão bibliográfica: O ozônio é um gás que apresenta atividade anti-inflamatória e antimicrobiana. Está disponível para aplicação como água ozonizada, óleo ozonizado ou o próprio gás. No endodonto, o ozônio realiza desinfecção do sistema de canais radiculares e dos túbulos dentinários, promovendo mais altos índices de sucesso do tratamento endodôntico. No periodonto, o ozônio promove ação antimicrobiana, desinfetante, curativa e de modulação do processo inflamatório, permitindo melhor reparo tecidual. Considerações finais: A ozonioterapia é uma eficaz terapia complementar em Odontologia, promovendo bons índices de sucesso nos tratamentos endodônticos e periodontais, com maior efetividade do tratamento odontológico e subsequente promoção de qualidade de vida.
Air Quality Assessment in an Oil and Gas Field at Atrush Area With Particulare Reference to Sulfur Dioxide and Nitrogen Dioixde
Authors: Assaf Omar Musheer , Abdulla Siraj Mohammed
Published: January 2023

The effectiveness and usability of a diffusion tube for air quality sampling were assessed at 14 sites throughout an oil and gas production area in Atrush sub-district for measurement of Sulfur dioxide (SO2) and nitrogen dioxide (NO2) in ambient air by Palmes diffusion tubes in air during autumn and winter season of 2021-2022.  Using triethanolamine as a trapping agent, the passive sampler collects SO2 and NO2, which are then proven to be sulphate and nitrite using ion chromatography and visible spectrometry. Ion chromatography was used to determine the respective dissolved ionic forms of SO2. Additionally, Ultraviolet-Visible (UV-Vis) spectrophotometry used to analyse NO2 as nitrite. Sulfur dioxide (SO2) concentration was high in locations close to flare with high elevation, as well as in winter season were higher than that of autumn season, the highest average of CPF (Central Processing Facility) is (26.39 ppb), however the highest concentration recorded is below Iraqi standard limit 140 ppb for 24 hr and lowest average at ECP3(Entry Check Point 3) (4.37 ppb) respectively. Nitrogen dioxide (NO2) concentrations were high in locations where heavy equipment’s operated and in diesel consumption areas, highest average of NO2 concentration of E pad (East Pad) is (8.94 ppb), and lowest average was in ECP3 (3.09 ppb).
Forage quality variation when using different management techniques for perennial pasture ecosystems
Authors: Привалова К.Н.
Published: January 2023

Приведены результаты исследований по оценке качества пастбищного корма долголетних фитоценозов в среднем за 46 лет (1976–2021 годы) для обоснования выбора пастбищной технологии. Базовой основой для определения качества зелёного корма являлся многолетний стационарный полевой опыт закладки 1946 года, проводимый в Федеральном научном центре кормопроизводства и агроэкологии им. В. Р. Вильямса. Схема опыта включает пастбищные технологии с различным уровнем минеральных и органических удобрений (техногенная — без удобрений, интегрированная — на фоне Р45К90, техногенно-минеральная — на двух фонах удобрений (N120Р45К90 и N180Р45К90) и техногенно-органическая — навоз 10 и 20 т/га один раз в 4 года). Впервые даётся анализ экспериментальных данных по циклам использования травостоев за 2017–2021 годы в соответствии с требованиями ГОСТ 57482-2017 «Корм пастбищный». Дана экспериментальная оценка сезонных изменений качества корма при различных сочетаниях природных факторов (температуры и количества осадков). Выявлены случаи получения неклассного (ниже 3-го класса) зелёного корма по содержанию основных показателей качества — сырого и переваримого протеина и сырой клетчатки, дано научное обоснование факторов риска с целью снижения их негативного влияния. При соблюдении режима использования долголетних (30–75 лет) фитоценозов и применении научно обоснованных доз удобрений качество корма по концентрации сырого протеина и сырой клетчатки при всех изучаемых технологиях соответствовало требованиям 1-го и 2-го классов. Для гарантированного получения качественного корма в годы с неблагоприятными погодными условиями вегетационных периодов необходимо применять интенсивную техногенно-минеральную технологию с внесением удобрения N180P45K90.

This article deals with the results on the forage quality of perennial ecosystems cultivated in the period of 1976–2021 to select optimal fertilization technique. To test the quality of green fodder an experiment started in 1946 was used at the Federal Williams Research Center of Fodder Production and Agroecology. The experimental design included different fertilization practices: using no fertilizers, integrated farming (Р45К90), mineral fertilizers (N120Р45К90 or N180Р45К90), and organic fertilizers (10 and 20 t ha-1 of manure once in 4 years). For the first time the data from 2017–2021 was analyzed according to GOST 57482-2017 “Korm pastbishchnyy”. Feed quality was tested with regard to seasonal variations in temperature and precipitation rates. At times low-quality green forage was obtained with poor contents of crude and digestible protein as well as crude fiber. Stress-factors were reviewed to decrease their negative effect on the forage. Optimal cultivation conditions for 30–75-year-old plant ecosystems and adequate rates of fertilizers provided sufficient concentrations of crude protein and fiber in all the variants resulting in fodder of the 1st and 2nd grade. To ensure forage quality under unfavorable conditions application of N180P45K90 was recommended.
État de Droit, langage et textualité juridique
Authors: Moor Pierre
Published: January 2023

Après un bref rappel des principes essentiels de l’État de Droit, l’auteur analyse la logique de l’application du droit dans la perspective de la sémiotique. Il met en évidence l’importance des normes à faible densité et l’imprévisibilité consécutive de la mise en œuvre des règles juridiques : les signes qui composent le texte à appliquer ne trouvent alors pleinement sens qu’en rapport avec le concret des cas d’espèce qui sont, au stade de l’application, leurs référents. S’il en résulte un déficit dans la réalisation maximale de l’État de Droit, la procéduralisation croissante des décisions étatiques le compense partiellement. De plus, l’imprévisibilité est inévitable, tant au regard de l’accomplissement des tâches étatiques que de la prise en considération par le juge, notamment sous l’angle de l’équité et de la justice, des situations concrètes.
Le tribunal d’Internet : réseaux sociaux, culture de l’annulation et discours de haine
Authors: Lorusso Anna Maria
Published: January 2023

Cette contribution vise à réfléchir sur certaines spécificités des modes de sanction sur les réseaux sociaux, transformés dans le régime actuel de post-vérité en véritables tribunaux de justice sommaire. En particulier, quatre aspects seront pris en considération : i) l’absence de dimension institutionnelle ; ii) le caractère ponctuel et improvisé sur le plan temporel ; iii) l’absence de logique probatoire sur le plan argumentatif ; iv) la caractérisation fortement phatique. La réflexion sur le rôle actantiel de l’expéditeur et sur le recours à l’assomption d’une communauté communicative de destination sera particulièrement importante.
Sémiotique et procès médiatique : les médias et la formation de l’opinion publique en thèmes de justice
Authors: Bassano Giuditta
Published: January 2023

L’article vise à articuler sémiotiquement un certain nombre de problèmes liés à la couverture médiatique du procès pénal. Ainsi, dans la première partie, il se concentre sur la nature narrative du procès pénal en tant que discours, et sur la différence entre l’énoncé et l’énonciation ; dans les deuxième et troisième parties, il met en évidence une possible syntaxe des rôles actoriels, médiatiques et juridiques par rapport aux problèmes de sanction et d’opinion publique ; dans la quatrième partie, il discute le régime de « vraisemblance sociale » proposé par Eric Landowski (1988) dans son modèle de quatre régimes de véridiction par rapport aux preuves judiciaires.
Anthropocène, Sémiotique et Droit de l’Environnement. La remise en cause juridique des non-humains
Authors: Tassinari Carlo Andrea
Published: January 2023

L’Anthropocène n’est pas l’époque d’une crise de la nature, mais l’époque d’une crise épistémique qui stimule la sémiotique de la culture à reprendre le projet d’une archéologie du savoir. Dans cet article nous donnons quelques indications pour en faire état dans le discours du droit de l’environnement. Nous nous focaliserons sur le tournant des années ‘60 et ‘70, très significatif pour le développement de cette branche du droit. À partir d’un un corpus comprenant droit national français, droit international et régulations européennes, nous proposerons d’abord une généalogie sémiotique des espaces naturels ; ensuite, nous montrerons comment elle conduit à la reformulation des temporalités juridiques ; enfin, nous terminerons par évoquer ses retombées sur l’actorialisation des non-humains en tant que sujets de droit.
Trajectories of identity, difference, and alterity in the context of the Russian-Ukrainian war
Authors: Pezzini Isabella
Published: January 2023

In this article, I propose a reflection on the concepts of identity/alterity, cooperation/conflict, ally/enemy, starting from the exceptional case of media representation of Ukraine, its president, and the background of the current conflict, given by the production of a prescient sitcom, by Zelenski himself, titled like the party that brought him success, in total continuity between reality and imagination.
Improved Performance of Positive-ion mode Free Radical-Initiated Peptide Sequencing with para-TEMPO-Bz
Authors: Osho Kemi , Wasik Kimberly , Geary Laina , Borotto Nicholas
Published: January 2023

Free radical-initiated peptide sequencing (FRIPS) is a tandem mass spectrometry (MS/MS) technique that generates sequence informative ions via collisionally-initiated radical chemistry. Collision activation homolytically cleaves an installed radical precursor, initiates radical formation, extensive hydrogen atom transfer, and peptide backbone dissociation. While the FRIPS technique shows great promise, when applied to multiply charged derivatized peptide ions, a series of high abundance mass losses are observed which syphon ion abundance from radically generated sequence ions. This loss of ion abundance reduces the sequence coverage generated by FRIPS fragmentation. In this work, we hypothesized that these mass losses were assisted by the ortho-orientation of the radical precursor undergoing facile conversion into five- or six-membered intermediates or products and that when combined with the lower bond dissociation energy of the para-precursor, conjugated peptides would not undergo this chemistry. To test this assertion, we synthesized para-TEMPO-Bz, conjugated it to these peptides, and collisionally activated each. And indeed, we see dramatic attenuation of these undesired collisional processes and the significant increase in radical precursor ion abundance. The increase in ion abundance leads to a significant increase in the sequence coverage generated. These results demonstrate that p-TEMPO-Bz significantly improves the performance of positive-ion mode FRIPS and may be a compelling alternative to the currently utilized ortho-TEMPO-Bz-based FRIPS.
Chemoenzymatic oxidation of diols catalyzed by co-immobilized flavins and dehydrogenases
Authors: Castillo Pacheco Sergio Fernando , Moran Plata Maria Jesus , Santos José Ignacio , Salassa Luca , López-Gallego Fernando
Published: January 2023

Enzyme driven oxidations catalyzed by alcohol dehydrogenases rely on the in situ NAD(P)+ regeneration. A wide variety of chemoenzymatic and fully enzymatic methods have been reported over the last 30 years to integrate the cofactor regeneration in biocatalytic oxidations. However, the most examples are limited to homogeneous systems where the reuse of both enzymes and chemical catalysts are challenging. In this work, we co-immobilized an alcohol dehydrogenase from Bacillus stearothermophilus with a flavin derivative (FMN), which performs as an organocatalyst that oxidizes NADH back to NAD+. This latter oxidized cofactor is sequentially utilized by the dehydrogenase to oxidize 1,-diols. Remarkably, the immobilization chemistry of the FMN determines its efficiency to recycle the nicotinamide cofactor and, unlike in its free state, the immobilized FMN can oxidizes NADH in dark. This was possible because the support where both enzyme and FMN are immobilized also captures NADH, and makes the electron transfer from the substrates to the cofactors more efficient. This work illustrates how the co-immobilization and confinement of bio and chemical catalysts on solid materials (heterogeneous system) enable chemoenzymatic cascades that are precluded in solution (homogeneous system).
Cu(I)-BOX Catalyzed Asymmetric 3-Component Reaction for the Synthesis of Trifluoromethylated Propargylic Ethers and Anilines
Authors: Ramirez Nieves P. , Waser Jerome
Published: January 2023

An asymmetric 3-component reaction between EthynylBenziodoXoles (EBxs), 2,2,2-trifluorodiazoethane and nucleophiles catalyzed by a Cu(I)Box catalyst is described. This protocol gives access to chiral trifluoromethylated propargyl ethers and anilines, which are valuable building blocks in synthetic and medicinal chemistry. The reaction proceeds with high enantioselectivity and yield with different nucleophiles such as primary, secondary and tertiary alcohols, as well as both electron-rich and electron-poor anilines. Aryl-, Alkyl- and silyl-substituted alkynes can be successfully introduced as electrophiles. In case of chiral substrates, high catalyst control was observed, leading to good diastereoselectivity.
Phenyl-Substituted Cibalackrot Derivatives: Synthesis, Structure, and Solution Photophysics
Authors: Kaleta Jiří , Dudič Miroslav , Ludvíková Lucie , Liška Alan , Zaykov Alexandr , Rončevič Igor , Mašát Milan , Bednárová Lucie , Dron Paul , Teat Simon , MICHL JOSEF
Published: January 2023

Three symmetrically and three unsymmetrically substituted cibalackrot (7,14-diphenyldiindolo[3,2,1-de:3',2',1'-ij][1,5]naphthyridine-6,13-dione, 1) dyes carrying two derivatized phenyl rings have been synthesized as candidates for molecular electronics and especially for singlet fission, a process of interest for solar energy conversion. Solution measurements provided singlet and triplet excitation energies and fluorescence yields and lifetimes; conformational properties were analyzed computationally. The molecular properties are close to ideal for singlet fission. However, crystal structures, obtained by single-crystal X-ray diffraction, are rather similar to those of the polymorphs of solid 1, in which formation of a charge-separated state followed by intersystem crossing, complemented with excimer formation, outcompetes singlet fission. Results of calculations by the approximate SIMPLE method suggest which ones among the solid derivatives are the best candidates for singlet fission, but it appears difficult to change the crystal packing in a desirable direction. We also describe the preparation of three specifically deuteriated versions of 1, expected to help sort out the mechanism of fast intersystem crossing in its charge-separated state.
Solvent induced 1H NMR chemical shifts of annulenes
Authors: Goyary Swrangsi , Sarmah Manash Jyoti , Goswami Himangshu Prabal , Nath Nilamoni
Published: January 2023

We investigate the effect of solvent polarity on the 1H NMR chemical shifts of [n]annulenes (n = 12, 18, and 30) using density functional theory and corroborate the computational results with Onsager’s reaction field theory. We observe that there is a complete deshielding of the proton NMR chemical shifts for the outer protons and these shifts depend linearly on the dielectric function of the solvents reaction field for certain annulenes (n = 12 and 30). For the asymmetric C2 structure of [18]annulene, the inner protons are observed to vary nonlinearly with the function of solvent dielectrics due to the influence of the asymmetry parameter “C”, which generates an anisotropic environment inside the annulene ring cavity.
Direct synthesis of functionalized 3-pyrrolidines and 4-piperidines using the borrowing hydrogen methodology
Authors: Larduinat Malvina , François Jordan , Jacolot Maiwenn , Popowycz Florence
Published: January 2023

The Ir(III)-catalyzed synthesis of 3-pyrrolidinols and 4-piperidinols combining 1,2,4-butanetriol or 1,3,5-pentanetriol with primary amines was carried out. This borrowing hydrogen methodology (BH) was further extended to the sequential diamination of triols leading to aza-pyrrolidines and aza-piperidines
Pentaenolate Activation in the Organocatalytic Allylic Alkylation of Indene-2-carbaldehydes
Authors: Cieśliński Adam , Frankowski Sebastian , Albrecht Łukasz
Published: January 2023

In the manuscript, the application of pentaenolate chemistry for the allylic alkylation of indene-2-carbaldehydes with Morita-Baylis-Hillman (MBH) carbonates is described. The reaction has been realized in a highly enantio- and diastereoselective manner owing to the use of chiral tertiary amine acting as nucleophilic catalyst. Developed reactivity constitutes the first application of organocatalytic pentaenolate activation in asymmetric synthesis expanding the arsenal of catalytic methods. It leads to the formation of synthetically useful building blocks for target oriented synthesis as confirmed in selected transformations of the products.
Advancing the economic and environmental sustainability of the NEWgeneratorTM non-sewered sanitation system
Authors: Guest Jeremy , Watabe Shion , Lohman Hannah , Li Yalin , Morgan Victoria , Rowles Lewis , Stephen Tyler , Shyu Hsiang-Yang , Bair Robert , Castro Cynthia , Cusick Roland , Yeh Daniel
Published: January 2023

Achieving safely managed sanitation and resource recovery in areas that are rural, geographically challenged, or experiencing rapidly increasing population density may not be feasible with centralized facilities due to space requirements, site-specific concerns, and high costs of sewer installation. Non-sewered sanitation (NSS) systems have the potential to provide safely managed sanitation and achieve strict wastewater treatment standards. One such NSS treatment (backend) technology is the NEWgeneratorTM, which includes an anaerobic membrane bioreactor (AnMBR), nutrient recovery via ion exchange, and electrochlorination. Although the system has been shown to achieve robust treatment of real waste streams for over 100 users, the technology’s relative life cycle sustainability across deployment locations remains unclear. This study characterizes the financial viability and life cycle environmental impacts of the NEWgeneratorTM and prioritizes opportunities to advance system sustainability through targeted improvements and deployment. The costs and greenhouse gas (GHG) emissions of the NEWgeneratorTM (general case) leveraging grid electricity were 0.139 [0.113 – 0.168] USD·cap-1·d-1 and 79.7 [55.0 – 112.3] kg CO2-eq·cap-1·yr-1, respectively. A transition to photovoltaic-generated electricity would increase costs to 0.145 [0.118 – 0.181] USD·cap-1·d-1 but decrease GHG emissions to 56.1 [33.8 – 86.2] kg CO2eq·cap-1·yr-1. The deployment location analysis demonstrated reduced median costs (relative to the general case) for deployment in China (-38%), India (-53%), Senegal (-31%), South Africa (-31%), and Uganda (-35%), but at comparable or increased GHG emissions (-2% to +16%). Examining targeted improvements revealed the relative change in median cost and GHG emissions to be -21% and -3% if loading is doubled (i.e., doubled users per unit), -30% and -12% with additional sludge drying, and +9% and -25% with the addition of a membrane contactor, respectively, with limited benefits (0-5% reductions) from an alternative photovoltaic battery, low-cost housing, or improved frontend operation. This research demonstrates the NEWgeneratorTM is a low-cost, low-emission NSS backend technology with the potential for resource recovery to increase access to safe sanitation.
Direct time-frequency response of electronic coherences in assemblies of colloidal CdSe quantum dot dimers probed at room temperature by 2-dimensional electronic spectroscopy
Authors: Remacle Francoise , Levine Raphael , Collini Elisabetta , Hamilton James , Dibenedetto Carlo , Striccoli Marinella , Amarotti Edoardo
Published: January 2023

The advantages of the directly measured time-frequency maps are discussed as a useful representation of the coherent output in a 2 dimensional electronic spectroscopy (2DES). We demonstrate the theory by a detailed application to the fast femtosecond beatings of a wide variety of electronic coherences in dimers of size-dispersed (9%) 3nm quantum dots (QDs). The observed and computed results can be consistently characterized directly in the time-frequency domain by probing the polarization in a 2DES set-up. Experimental and computed time-frequency maps are found in very good agreement and several electronic coherences are characterized at room temperature in solution before extensive dephasing due to the size-dispersion kicks in. As compared to the frequency-frequency maps that are commonly used in 2DES, the time-frequency maps allow for exploiting electronic coherences without additional post processing and with fewer 2DES measurements of polarization. Towards quantum technology applications, we also report on the modeling of the time-frequency photocurrent response of these electronic coherences, which opens the way to integrating QD devices with classical architectures thereby enhancing the quantum advantage of such technologies for parallel information processing at room temperature.
Accelerated Chemical Reaction Optimization using Multi-Task Learning
Authors: Taylor Connor , Felton Kobi , Wigh Daniel , Jeraal Mohammed , Grainger Rachel , Chessari Gianni , Johnson Christopher , Lapkin Alexei
Published: January 2023

Functionalization of C–H bonds is a key challenge in medicinal chemistry, particularly for fragment-based drug discovery (FBDD) where such transformations need to be executed in the presence of polar functionality necessary for fragment-protein binding. New technologies such as high-throughput experimentation and self-optimization have the potential to revolutionize synthetic approaches to challenging target molecules in FBDD. Recent work has shown the effectiveness of Bayesian optimization (BO) for the self-optimization of chemical reactions, however, in all previous cases these algorithmic procedures have started with no prior information about the reaction of interest. In this work, we explore the use of multi-task Bayesian optimization (MTBO) in several in silico case studies by leveraging reaction data collected during related historical optimization campaigns to accelerate the optimization of new reactions - this was performed for Suzuki-Miyaura and C–N couplings. This methodology was then translated to real-world, medicinal chemistry applications in the yield optimization of several pharmaceutical intermediates using an autonomous flow-based reactor platform. The use of the MTBO algorithm was shown to be successful in determining optimal conditions (both continuous and categorical variables) of unseen experimental C–H activation reactions with differing substrates, demonstrating up to a 98 % cost reduction when compared to industry-standard process optimization techniques. Our findings highlight the effectiveness of the methodology as an enabling tool in medicinal chemistry workflows, where efficient utilization of precious starting materials is particularly important. This work represents a step-change in the utilization of previously obtained reaction data and machine learning with the ultimate goal of accelerated reaction optimization.
Understanding the Unique Optical and Vibrational Signatures of Sequential Infiltration Synthesis Derived Indium Oxyhydroxide Clusters for CO2 Absorption
Authors: Kunene Thabiso , Martinson Alex B.F.
Published: January 2023

Sequential infiltration synthesis (SIS) is a vapor phase synthesis technique with potential to exert precise control over metal oxyhydroxide incorporation into polymer scaffolds. We observe strong size-dependent properties of InOx(OH)y few-atom clusters deposited with variable SIS cycle numbers within a polymethylmethacrylate (PMMA) matrix. Infrared and ultraviolet absorption spectroscopy reveal that the metal atom coordination and optical properties of the clusters depend on the number of SIS cycles performed as well as the choice of processing parameters. The incorporation of indium oxyhydroxide in PMMA via SIS improves the gravimetric CO2 absorption capacity, demonstrating a novel platform with potential for CO2 activation.
How do Cyclopropane Fatty Acids Protect the Cell Membrane of Escherichia coli in Cold Shock?
Authors: Maiti Archita , Kumar Abhay , Daschakraborty Snehasis
Published: January 2023

The cyclopropanation of unsaturated lipid acyl chains of some bacterial cell membranes is an important survival strategy to protect the same against drastic cooling. To elucidate the role of cyclopropane ring containing lipids, we have simulated the lipid membrane of Escherichia coli (E. coli) and two modified membranes by replacing the cyclopropane rings with either single or double bonds at widely different temperatures. It has been observed that the cyclopropane rings provide more rigid kinks in the lipid acyl chain compared to the double bonds and therefore further reduce the packing density of the membrane and subsequently enhance the membrane fluidity at low temperatures. They also inhibit the close packing of other lipids and deleterious phase separation by strongly interacting with them. Therefore, this study has explained why E. coli bacterial strain, susceptible to freezing environment, relies on the cyclopropanation of an unsaturated chain.
TikTok y cambio climático: comunicar sin fuentes ni soluciones
Authors: Nieto-Sandoval Alejandra G. , Ferré-Pavia Carme
Published: January 2023

El presente artículo presenta un estudio exploratorio de la comunicación sobre el cambio climático (CC) en la red social TikTok durante la Cumbre Climática de 2021 (Glasgow, 1-12 noviembre 2021), considerada como la última oportunidad para frenar el avance del CC. Para ello, se han examinado mediante análisis de contenido los 100 vídeos con mayor número de visualizaciones durante esta celebración. Los resultados han mostrado un nuevo escenario comunicativo en el que los influencers son los actores que mayor número de vídeos publican sobre el CC. Los medios de comunicación continúan siendo un actor fundamental en la comunicación del CC y otorgan continuidad y relevancia al asunto. Otro resultado remarcable es una alarmante situación: la mayoría de los vídeos no citan ningún tipo de fuente de información. Los casos en los que se refieren fuentes son principalmente medios de comunicación que, a su vez, no informan del origen de los datos trasmitidos. Se puede concluir que la mayoría de los usuarios en TikTok de la muestra analizada aceptan el CC como un hecho verídico, sin embargo, no plantean situaciones de cambio, siendo meros sujetos pasivos.
Impact of Serratiopeptidase on Bleeding and Clotting Time at Therapeutic Dose
Authors: Jothieswari D  , Srihari M V  , Karthik R  , Praveen Kumar V  , Sumit Giri
Published: January 2023

Serratiopeptidase is a proteolytic enzyme that was being used for decades as an anti-inflammatory agent. It was initially synthesized from the larval form of the silk moth. It is ubiquitously prescribed in combination with NSAIDs to relieve pain and inflammation. In addition to desired pharmacological activity, it has some other effects. One among which is fibrinolytic activity. Fibrin is an activated form of fibrinogen formed as a result of injury to mitigate the loss of blood. Inactive plasminogen activates plasmin which is a proteolytic enzyme. As its chemical nature, it solubilizes the fibrin at a specific time to prevent embolism. Serralysin being proteolytic in nature interacts with the fibrin and degrades it into degradation particles which lead to uncontrollable bleeding. This improves the chance of deviation in BT and CT in subjects from initial readings. This analytical study was conducted on 20 participants who are admitted to a public hospital with other ailments and their variations in BT and CT were recorded, analyzed, and represented in the form of charts.
Leads for Scientific Writing in Ayurveda Literature
Authors: B R Ramakrishna Dr.
Published: January 2023

None
Review of implementation of animal model for diagnosis of past and present with special reference to Canis familiaris
Authors: D Shetty Deeksha , Kumar M Arun , N Mogasale Prasanna , S Nagaraj
Published: January 2023

Science has always given utmost value to diagnosis that is recognizing or verifying facts. But medicine has more to give in this field than any other. Throughout the ages a varied number of upgrades are gradually seen in the area of diagnosis. Acharya has explained a varied number of diagnostic tools to achieve the goal of identifying a disease by a spectrum of applications of sense organs.In the context of pratyaksha pareeksha that is direct observations Acharya has explained that the taste of different tissues of the patient is without a doubt an object of gustatory sense organs. He gave an example of raktapitta bleeding disorder wherein he explained how the purity of blood and blood vitiated by pitta can be observed in contrast by feeding the blood to a dog and crow. The most recent development in this concept of the use of animal models especially Canis familiaris dogs surfaced during the efflux of the COVID-19 pandemic. Hence an attempt to study and widen the concept of the application of animals in the area of medicine past and present.