bluuebunny/crossref_metadata_2025 huggingface dataset:
Initial Intraoperative Experience with Robotic-Assisted Pedicle Screw Placement with Cirq® Robotic Alignment: An Evaluation of the First 70 Screws
Authors: Pojskić Mirza , Bopp Miriam , Nimsky Christopher , Carl Barbara , Saβ Benjamin
Published: December 2021

Background: Robot-guided spine surgery is based on a preoperatively planned trajectory that is reproduced in the operating room by the robotic device. This study presents our initial experience with thoracolumbar pedicle screw placement using Brainlab’s Cirq® surgeon-controlled robotic arm (BrainLab, Munich, Germany). Methods: All patients who underwent robotic-assisted implantation of pedicle screws in the thoracolumbar spine were included in the study. Our workflow, consisting of preoperative imagining, screw planning, intraoperative imaging with automatic registration, fusion of the preoperative and intraoperative imaging with a review of the preplanned screw trajectories, robotic-assisted insertion of K-wires, followed by a fluoroscopy-assisted insertion of pedicle screws and control iCT scan, is described. Results: A total of 12 patients (5 male and 7 females, mean age 67.4 years) underwent 13 surgeries using the Cirq® Robotic Alignment Module for thoracolumbar pedicle screw implantation. Spondylodiscitis, metastases, osteoporotic fracture, and spinal canal stenosis were detected. A total of 70 screws were implanted. The mean time per screw was 08:27 ± 06:54 min. The mean time per screw for the first 7 surgeries (first 36 screws) was 16:03 ± 09:32 min and for the latter 6 surgeries (34 screws) the mean time per screw was 04:35 ± 02:11 min (p < 0.05). Mean entry point deviation was 1.9 ± 1.23 mm, mean deviation from the tip of the screw was 2.61 ± 1.6 mm and mean angular deviation was 3.5° ± 2°. For screw-placement accuracy we used the CT-based Gertzbein and Robbins System (GRS). Of the total screws, 65 screws were GRS A screws (92.85%), one screw was a GRS B screw, and two further screws were grade C. Two screws were D screws (2.85%) and underwent intraoperative revision. There were no perioperative deficits. Conclusion: Brainlab’s Cirq® Robotic Alignment surgeon-controlled robotic arm is a safe and beneficial method for accurate thoracolumbar pedicle screw placement with high accuracy.
The Effectiveness of Computer-Assisted Cognitive Rehabilitation and the Degree of Recovery in Patients with Traumatic Brain Injury and Stroke
Authors: Jung Hyunwoo , Jeong Jae-Gyeong , Cheong Youn-Soo , Nam Tae-Woo , Kim Ju-Hyun , Park Chan-Hee , Park Eunhee , Jung Tae-Du
Published: December 2021

Objectives: To determine the effectiveness of computer-assisted cognitive rehabilitation and compare the patterns of cognitive function recovery occurring in both traumatic brain injury (TBI) and stroke. Methods: A total of 62 patients were finally enrolled, consisting of 30 with TBI and 32 with stroke. The patients received 30 sessions of computer-assisted cognitive rehabilitation (Comcog) five times per week. Each session lasted for 30 min. Before and immediately after cognitive rehabilitation, all patients were evaluated by computerized neuropsychological test (CNT), Mini-Mental State Examination (MMSE), and modified Barthel index (MBI). Results: We analyzed the differences between pre- and post-cognitive rehabilitation in each TBI and stroke group. Significant differences were observed in MMSE, MBI, and some CNT contents, including digit span forward, verbal learning, verbal learning delayed recall, visual span forward, visual span backward, visual learning, trail making test A and B, and intelligence quotient (IQ) in the TBI group (p < 0.05). In the stroke group, in addition to significant differences that appeared in the TBI group, additional significant differences in the digit span backward, visual learning delayed recall, auditory continuous performance test (CPT), visual CPT, and card sorting test. We compared the difference values at pre- and post-cognitive rehabilitation for cognitive recovery between the TBI and stroke groups. All contents, except the digital span forward, visual learning, word-color test, and MMSE, had greater mean values in the stroke group; and thus, statistically significant higher values were observed in the visual span forward and card sorting test (p < 0.05). Conclusion: Most evaluation results showed improvement and the evaluation between the TBI and stroke groups also showed significant differences in cognitive functions in addition to more CNT contents, which significantly change in the stroke group. The stroke group showed a high difference value in most CNT contents. Therefore, those with stroke in the focal brain region tend to have better cognitive function recovery after a computer-assisted cognitive rehabilitation than those with TBI, which could cause diffuse brain damage and post-injury inflammation.
Proteomic Analysis of Aqueous Humor Proteins in Association with Cataract Risks: Diabetes and Smoking
Authors: Chang Wei-Cheng , Lee Cho-Hao , Chiou Shih-Hwa , Liao Chen-Chung , Cheng Chao-Wen
Published: December 2021

Cataracts are one of the most common eye diseases that can cause blindness. Discovering susceptibility factors in the proteome that contribute to cataract development would be helpful in gaining new insights in the molecular mechanisms of the cataract process. We used label-free nanoflow ultra-high-performance liquid chromatography–tandem mass spectrometry to compare aqueous humor protein expressions in cataract patients with different cataract risk factors such as diabetes mellitus (DM) and smoking and in controls (with cataract) without risk exposure. Eight patients with diabetes and who smoked (with double risk factors), five patients with diabetes and five patients who smoked (both with a single risk factor), and nine aged-matched cataract controls patients (non-risk exposure) were enrolled. In total, 136 aqueous humor proteins were identified, of which only alpha-2-Heremans–Schmid (HS)-glycoprotein was considered to be significantly risk-associated because it was differentially expressed in these three groups and exhibited increased expression with increasing risk factors. Significant changes in the aqueous humor level of alpha-2-HS-glycoprotein between DM and control samples and between smoking and control samples were confirmed using ELISA. The alpha-2-HS-glycoprotein, called fetuin-a, could be a potential aqueous biomarker associated with DM and smoking, which were cataract risk factors.
Preterm Birth and Small-for-Gestational Age Neonates among Prepregnancy Underweight Women: A Case-Controlled Study
Authors: Lefizelier Emelyne , Misbert Emilie , Brooks Marion , Le Thuaut Aurélie , Winer Norbert , Ducarme Guillaume
Published: December 2021

The aim of our study was to investigate whether prepregnancy underweight body mass index (BMI) is associated with preterm birth (PTB) and small-for-gestational age (SGA). This retrospective case-control study included 814 women with live singleton fetuses in vertex presentation that gave birth between January 2016 and November 2016 in two tertiary care hospitals. The study group (n = 407) comprised all women whose prepregnancy BMI was underweight (<18.5 kg/m2) and who delivered during the study period. A control group (n = 407) was established with women whose prepregnancy BMI was normal (18.5–24.9 kg/m2) by matching age and parity. Univariate and multivariate analyses were performed to compare PTB and SGA associated with prepregnancy underweight BMI. Compared with the control group, the study group had higher rates of overall PTB (10.1% vs. 5.7%, p = 0.02), iatrogenic PTB (4.2% vs. 1.5%, p = 0.02), and SGA (22.1% vs. 11.1%, p < 0.001). In a multivariable analysis, prepregnancy underweight BMI was associated with PTB (aOR 2.32, 95% CI 1.12–4.81) and with SGA (aOR 2.38, 95% CI 1.58–3.58). In singleton pregnancies, women’s prepregnancy underweight compared with normal BMI was associated with an increase in PTB and in SGA neonates. Identifying this specific high-risk group is pragmatic and practical for all physicians, and they should be aware about perinatal outcome among underweight women.
A Review of Sensing Technologies for Non-Destructive Evaluation of Structural Composite Materials
Authors: Gupta Ranjeetkumar , Mitchell Daniel , Blanche Jamie , Harper Sam , Tang Wenshuo , Pancholi Ketan , Baines Lee , Bucknall David G. , Flynn David
Published: December 2021

The growing demand and diversity in the application of industrial composites and the current inability of present non-destructive evaluation (NDE) methods to perform detailed inspection of these composites has motivated this comprehensive review of sensing technologies. NDE has the potential to be a versatile tool for maintaining composite structures deployed in hazardous and inaccessible areas, such as offshore wind farms and nuclear power plants. Therefore, the future composite solutions need to take into consideration the niche requirements of these high-value/critical applications. Composite materials are intrinsically complex due to their anisotropic and non-homogeneous characteristics. This presents a significant challenge for evaluation and the associated data analysis for NDEs. For example, the quality assurance, certification of composite structures, and early detection of the failure is complex due to the variability and tolerances involved in the composite manufacturing. Adapting existing NDE methods to detect and locate the defects at multiple length scales in the complex materials represents a significant challenge, resulting in a delayed and incorrect diagnosis of the structural health. This paper presents a comprehensive review of the NDE techniques, that includes a detailed discussion of their working principles, setup, advantages, limitations, and usage level for the structural composites. A comparison between these techniques is also presented, providing an insight into the future trends for composites’ prognostic and health management (PHM). Current research trends show the emergence of the non-contact-type NDE (including digital image correlation, infrared tomography, as well as disruptive frequency-modulated continuous wave techniques) for structural composites, and the reasons for their choice over the most popular contact-type (ultrasonic, acoustic, and piezoelectric testing) NDE methods is also discussed. The analysis of this new sensing modality for composites’ is presented within the context of the state-of-the-art and projected future requirements.
Gold Nanoparticles: Biosynthesis and Potential of Biomedical Application
Authors: Mikhailova Ekaterina O.
Published: December 2021

Gold nanoparticles (AuNPs) are extremely promising objects for solving a wide range of biomedical problems. The gold nanoparticles production by biological method (“green synthesis”) is eco-friendly and allows minimization of the amount of harmful chemical and toxic byproducts. This review is devoted to the AuNPs biosynthesis peculiarities using various living organisms (bacteria, fungi, algae, and plants). The participation of various biomolecules in the AuNPs synthesis and the influence of size, shapes, and capping agents on the functionalities are described. The proposed action mechanisms on target cells are highlighted. The biological activities of “green” AuNPs (antimicrobial, anticancer, antiviral, etc.) and the possibilities of their further biomedical application are also discussed.
Supervised Versus Unsupervised Pulmonary Rehabilitation in Patients with Pulmonary Embolism: A Valuable Alternative in COVID Era
Authors: Stavrou Vasileios T. , Griziotis Michalis , Vavougios George D. , Raptis Dimitrios G. , Bardaka Fotini , Karetsi Eleni , Kyritsis Athanasios , Daniil Zoe , Tsarouhas Konstantinos , Triposkiadis Filippos , Gourgoulianis Konstantinos I. , Malli Foteini
Published: December 2021

The aim of our study was to assess the effect of 8 weeks of pulmonary rehabilitation (PR) in patients with pulmonary embolism (PE) during unsupervised PR (unSPRgroup) versus supervised PR (SPRgroup) on cardiopulmonary exercise testing (CPET) parameters, sleep quality, quality of life and cardiac biomarkers (NT-pro-BNP). Fourteen patients with PE (unSPRgroup, n = 7, vs. SPRgroup, n = 7) were included in our study (age, 50.7 ± 15.1 years; BMI, 30.0 ± 3.3 kg/m2). We recorded anthropometric characteristics and questionnaires (Quality of life (SF-36) and Pittsburg sleep quality index (PSQI)), we performed blood sampling for NT-pro-BNP measurement and underwent CPET until exhausting before and after the PR program. All patients were subjected to transthoracic echocardiography prior to PR. The SPRgroup differed in mean arterial pressure at rest before and after the PR program (87.6 ± 3.3 vs. 95.0 ± 5.5, respectively, p = 0.010). Patients showed increased levels of leg fatigue (rated after CPET) before and after PR (p = 0.043 for SPRgroup, p = 0.047 for unSPRgroup) while the two groups differed between each other (p = 0.006 for post PR score). Both groups showed increased levels in SF-36 scores (general health; p = 0.032 for SPRgroup, p = 0.010 for unSPRgroup; physical health; p = 0.009 for SPRgroup, p = 0.022 for unSPRgroup) and reduced levels in PSQI (cannot get to sleep within 30-min; p = 0.046 for SPRgroup, p = 0.007 for unSPRgroup; keep up enough enthusiasm to get things done; p = 0.005 for SPRgroup, p = 0.010 for unSPRgroup) following the PR program. The ΝT-pro-BNP was not significantly different before and after PR or between groups. PR may present a safe intervention in patients with PE. The PR results are similar in SPRgroup and unSPRgroup.
Flow-Particle Coupling in a Channel Flow Laden with Elongated Particles: The Role of Aspect Ratio
Authors: Capone Alessandro , Di Felice Fabio , Alves Pereira Francisco
Published: December 2021

A turbulent channel flow laden with elongated, fiber-like particles is investigated experimentally by optical techniques. The flow-particle inter-coupling is analyzed in the case of particles with an aspect ratio of 40 and 80, at two volume fractions, 10−5 and 10−4. An image processing technique is presented, which is employed to simultaneously obtain carrier flow velocimetry data and distribution and orientation data of dispersed particles. Turbulence enhancement is reported in the near-wall region, with a higher level of increase associated with higher aspect ratio particles. Comparison to fiber data suggests that this mechanism of turbulence modulation stems from a particles orientational behavior. The preferential particle distribution is reported to be dependent on the aspect ratio in the region close to the wall. The probability density function of the fibers’ orientation angle appears to be independent of the particle aspect ratio once it is conditioned to the fibers’ characteristic size.
Impacts of the Wave-Dependent Sea Spray Parameterizations on Air–Sea–Wave Coupled Modeling under an Idealized Tropical Cyclone
Authors: Xu Xingkun , Voermans Joey J. , Liu Qingxiang , Moon Il-Ju , Guan Changlong , Babanin Alexander V.
Published: December 2021

While sea spray can significantly impact air–sea heat fluxes, the effect of spray produced by the interaction of wind and waves is not explicitly addressed in current operational numerical models. In the present work, the thermal effects of the sea spray were investigated for an idealized tropical cyclone (TC) through the implementation of different sea spray models into a coupled air–sea–wave numerical system. Wave-Reynolds-dependent and wave-steepness-dependent sea spray models were applied to test the sensitivity of local wind, wave, and ocean fields of this TC system. Results show that while the sensible heat fluxes decreased by up to 231 W m−2 (364%) and 159 W m−2 (251%), the latent heat fluxes increased by up to 359 W m−2 (89%) and 263 W m−2 (76%) in the simulation period, respectively. This results in an increase of the total heat fluxes by up to 135 W m−2 (32%) and 123 W m−2 (30%), respectively. Based on different sea spray models, sea spray decreases the minimum sea level pressure by up to 7 hPa (0.7%) and 8 hPa (0.8%), the maximum wind speed increases by up to 6.1 m s−1 (20%) and 5.7 m s−1 (19%), the maximum significant wave height increases by up to 1.1 m (17%) and 1.6 m (25%), and the minimum sea surface temperature decreases by up to 0.2 °C (0.8%) and 0.15 °C (0.6%), respectively. As the spray has such significant impacts on atmospheric and oceanic environments, it needs to be included in TC forecasting models.
Prediction of Maneuverability in Shallow Water of Fishing Trawler by Using Empirical Formula
Authors: Kim Su-Hyung , Lee Chun-Ki , Chae Yang-Bum
Published: December 2021

The length between perpendiculars (LBP) of most fishing vessels is less than 100 m. Thus, they are not subject to the International Maritime Organization (IMO) maneuverability standards, affecting research on maneuverability. However, upon referencing the statistics of marine accidents related to vessel maneuvering, the number of marine accidents caused by fishing vessels is 3 to 5 times higher than that of merchant ships. Therefore, systematic and consistent research on the maneuverability characteristics of fishing vessels is surely required. In particular, a fishing vessel frequently enters and departs from the same port and often sails at high speed due to familiarity with the characteristics of the situation, which may cause maneuvering-related accidents. In this study, the maneuverability of a fishing vessel in shallow water was predicted using an empirical formula. The results of this study are expected to not only be of great help in conducting simulations when analyzing marine accidents involving fishing vessels, but will also provide unique parameters of fishing vessels that lead to developing autonomous vessels.
The Sizes, Growth and Reproduction of Arrow Worms (Chaetognatha) in Light of the Gill-Oxygen Limitation Theory (GOLT)
Authors: Pauly Daniel , Liang Cui , Xian Weiwei , Chu Elaine , Bailly Nicolas
Published: December 2021

The Chaetognatha are a marine invertebrate phylum including 132 extant, carnivorous species in nine families and two orders, but with unclear protostomian affinities in the animal kingdom. We document the gradual recognition of the distinctiveness of chaetognaths by early taxonomists, with some emphasis on the often-overlooked studies by Chinese marine biologists. The carnivorous arrow worms are understudied relative to their importance in the marine zooplankton, where they rank second in abundance after the herbivorous copepods. Although arrow worms lack gills or other dedicated respiratory organs, we show that the Gill-Oxygen Limitation Theory (GOLT) can be used to explain how temperature and respiration affect their growth and related life-history traits. Notably, we present a reappraisal of evidence for size–temperature relationships between and within chaetognath species, and for the relationship between their temperature-mediated oxygen demand and their growth patterns. Von Bertalanffy weight growth curves of Ferosagitta hispida (family: Sagittidae) based on earlier aquarium experiments by various authors are presented, which suggest (a) a good fit and (b) that the life span of chaetognaths is much lower than suggested by the authors of several published growth curves drawn onto length–frequency samples from the wild. In addition, we show that chaetognaths attain first maturity at a fraction of the maximum length they can attain that is similar to the corresponding fraction in fishes. Overall, we suggest that the manner in which the oxygen they require enters the body of small marine invertebrates, although often neglected, is a crucial aspect of their biology. In addition, based on our result that arrow worms conform to the GOLT, we suggest that this theory may provide the theoretical framework for the study of growth in the other water-breathing ectotherms lacking gills.
Fungal Laccases: The Forefront of Enzymes for Sustainability
Authors: Loi Martina , Glazunova Olga , Fedorova Tatyana , Logrieco Antonio F. , Mulè Giuseppina
Published: December 2021

Enzymatic catalysis is one of the main pillars of sustainability for industrial production. Enzyme application allows minimization of the use of toxic solvents and to valorize the agro-industrial residues through reuse. In addition, they are safe and energy efficient. Nonetheless, their use in biotechnological processes is still hindered by the cost, stability, and low rate of recycling and reuse. Among the many industrial enzymes, fungal laccases (LCs) are perfect candidates to serve as a biotechnological tool as they are outstanding, versatile catalytic oxidants, only requiring molecular oxygen to function. LCs are able to degrade phenolic components of lignin, allowing them to efficiently reuse the lignocellulosic biomass for the production of enzymes, bioactive compounds, or clean energy, while minimizing the use of chemicals. Therefore, this review aims to give an overview of fungal LC, a promising green and sustainable enzyme, its mechanism of action, advantages, disadvantages, and solutions for its use as a tool to reduce the environmental and economic impact of industrial processes with a particular insight on the reuse of agro-wastes.
Huntingtin Ubiquitination Mechanisms and Novel Possible Therapies to Decrease the Toxic Effects of Mutated Huntingtin
Authors: Fiorillo Annarita , Morea Veronica , Colotti Gianni , Ilari Andrea
Published: December 2021

Huntington Disease (HD) is a dominant, lethal neurodegenerative disorder caused by the abnormal expansion (>35 copies) of a CAG triplet located in exon 1 of the HTT gene encoding the huntingtin protein (Htt). Mutated Htt (mHtt) easily aggregates, thereby inducing ER stress that in turn leads to neuronal injury and apoptosis. Therefore, both the inhibition of mHtt aggregate formation and the acceleration of mHtt degradation represent attractive strategies to delay HD progression, and even for HD treatment. Here, we describe the mechanism underlying mHtt degradation by the ubiquitin–proteasome system (UPS), which has been shown to play a more important role than the autophagy–lysosomal pathway. In particular, we focus on E3 ligase proteins involved in the UPS and detail their structure–function relationships. In this framework, we discuss the possible exploitation of PROteolysis TArgeting Chimeras (PROTACs) for HD therapy. PROTACs are heterobifunctional small molecules that comprise two different ligands joined by an appropriate linker; one of the ligands is specific for a selected E3 ubiquitin ligase, the other ligand is able to recruit a target protein of interest, in this case mHtt. As a consequence of PROTAC binding, mHtt and the E3 ubiquitin ligase can be brought to a relative position that allows mHtt to be ubiquitinated and, ultimately, allows a reduction in the amount of mHtt in the cell.
Bone and Joint Infections: The Role of Imaging in Tailoring Diagnosis to Improve Patients’ Care
Authors: Sambri Andrea , Spinnato Paolo , Tedeschi Sara , Zamparini Eleonora , Fiore Michele , Zucchini Riccardo , Giannini Claudio , Caldari Emilia , Crombé Amandine , Viale Pierluigi , De Paolis Massimiliano
Published: December 2021

Imaging is needed for the diagnosis of bone and joint infections, determining the severity and extent of disease, planning biopsy, and monitoring the response to treatment. Some radiological features are pathognomonic of bone and joint infections for each modality used. However, imaging diagnosis of these infections is challenging because of several overlaps with non-infectious etiologies. Interventional radiology is generally needed to verify the diagnosis and to identify the microorganism involved in the infectious process through imaging-guided biopsy. This narrative review aims to summarize the radiological features of the commonest orthopedic infections, the indications and the limits of different modalities in the diagnostic strategy as well as to outline recent findings that may facilitate diagnosis.
Psychoneurobiology Research and Personalized Treatment of Schizophrenia
Authors: Sumiyoshi Tomiki
Published: December 2021

Psychoneurobiological approaches have been used to develop effective treatments for unmet needs in schizophrenia, e [...]
Dysregulated Notch Signaling in the Airway Epithelium of Children with Wheeze
Authors: Iosifidis Thomas , Sutanto Erika N. , Montgomery Samuel T. , Agudelo-Romero Patricia , Looi Kevin , Ling Kak-Ming , Shaw Nicole C. , Garratt Luke W. , Hillas Jessica , Martinovich Kelly M. , Kicic-Starcevich Elizabeth , Vijayasekaran Shyan , Lannigan Francis J. , Rigby Paul J. , Knight Darryl A. , Stick Stephen M. , Kicic Anthony
Published: December 2021

The airway epithelium of children with wheeze is characterized by defective repair that contributes to disease pathobiology. Dysregulation of developmental processes controlled by Notch has been identified in chronic asthma. However, its role in airway epithelial cells of young children with wheeze, particularly during repair, is yet to be determined. We hypothesized that Notch is dysregulated in primary airway epithelial cells (pAEC) of children with wheeze contributing to defective repair. This study investigated transcriptional and protein expression and function of Notch in pAEC isolated from children with and without wheeze. Primary AEC of children with and without wheeze were found to express all known Notch receptors and ligands, although pAEC from children with wheeze expressed significantly lower NOTCH2 (10-fold, p = 0.004) and higher JAG1 (3.5-fold, p = 0.002) mRNA levels. These dysregulations were maintained in vitro and cultures from children with wheeze displayed altered kinetics of both NOTCH2 and JAG1 expression during repair. Following Notch signaling inhibition, pAEC from children without wheeze failed to repair (wound closure rate of 76.9 ± 3.2%). Overexpression of NOTCH2 in pAEC from children with wheeze failed to rescue epithelial repair following wounding. This study illustrates the involvement of the Notch pathway in airway epithelial wound repair in health and disease, where its dysregulation may contribute to asthma development.
Tumor Inflammation, Obesity, and Proliferative Status as Biomarkers in Gastroesophageal Adenocarcinoma
Authors: Mukherjee Sarbajit , Seager R. J. , Lee Yong Hee , Conroy Jeffrey M. , Kalinski Pawel , Pabla Sarabjot
Published: December 2021

Recent epidemiological studies have shown that obesity, typically measured by increased body mass index (BMI), is associated with an increased risk of gastroesophageal adenocarcinoma (GEAC), but the contributing molecular and immune mechanisms remain unknown. Since obesity is known to promote chronic inflammation, we hypothesized that obesity leads to inflammation-related immune dysfunction, which can be reversed by immune-modulating therapy. To test our hypothesis, we examined the clinical and molecular data from advanced GEAC patients. To this end, 46 GEAC tumors were evaluated for biomarkers representing tumor inflammation, cell proliferation, and PD-L1 expression. A CoxPH regression model with potential co-variates, followed by pairwise post hoc analysis, revealed that inflammation in the GEAC tumor microenvironment is associated with improved overall survival, regardless of BMI. We also observed a significant association between cell proliferation and progression-free survival in overweight individuals who received immune-modulating therapy. In conclusion, our data confirm the role of the immune system in the natural course of GEAC and its responses to immunotherapies, but do not support the role of BMI as an independent clinically relevant biomarker in this group of patients.
COVID-19: An Economic or Social Disease? Implications for Disadvantaged Populations
Authors: Nasir Hijrah , Navel Valentin , Baker Julien S , Supriya Rashmi , Cole Alistair , Gao Yang , Dutheil Frederic
Published: December 2021

The world is still struggling against the coronavirus (COVID-19) pandemic [...]
Lifestyle Properties, Ecosystem Services, and Biodiversity Protection in Peri-Urban Aotearoa–New Zealand: A Case Study from Peri-Urban Palmerston North
Authors: Pearson Diane
Published: December 2021

Intensive agriculture and urbanization are putting pressure on natural capital in Aotearoa–New Zealand (NZ), with native ecosystems and water quality suffering degradation. As the population has increased, so development has pushed into the rural–urban fringe. Over the last 30 years, the number of lifestyle properties in NZ has increased dramatically. Many of these properties have been developed on some of NZ’s most productive soils, meaning a loss of provisioning services from this land. However, given their location, these developments present new opportunities for the enhancement and protection of other ecosystem services. This paper presents the findings of an exploratory study conducted on lifestyle block residents in peri-urban Palmerston North. The results showed that these residents have a good sense of environmental stewardship and a desire to plant native species, improve connectivity, and protect their land from the invasion of pests and weeds. These residents are also quite community-focused and protective of their special place. This creates an excellent basis from which to encourage greater collaborative action towards protecting and enhancing biodiversity and to put in place land management strategies that can enhance natural capital and assist in other ecosystem service protection serving to improve the landscape ecology of peri-urban environments.
Spatial Interactions in Business and Housing Location Models
Authors: Kopczewska Katarzyna , Kopyt Mateusz , Ćwiakowski Piotr
Published: December 2021

The paper combines theoretical models of housing and business locations and shows that they have the same determinants. It evidences that classical, behavioural, new economic geography, evolutionary and co-evolutionary frameworks apply simultaneously, and one should consider them jointly when explaining urban structure. We use quantitative tools in a theory-guided factors induction approach to show the complexity of location models. The paper discusses and measures spatial phenomena as distance-decaying gradients, spatial discontinuities, densities, spillovers, spatial interactions, agglomerations, and as multimodal processes. We illustrate the theoretical discussion with an empirical case of interacting point-patterns for business, housing, and population. The analysis reveals strong links between housing valuation and business location and profitability, accompanied by the related spatial phenomena. It also shows that assumptions concerning unimodal spatial urban structure, the existence of rational maximisers, distance-decaying externalities, and a single pattern of behaviour, do not hold. Instead, the reality entails consideration of multimodality, a mixture of maximisers and satisfiers, incomplete information, appearance of spatial interactions, feed-back loops, as well as the existence of persistence of behaviour, with slow and costly adjustments of location.
Effects of Spatial Elements of Urban Landscape Forests on the Restoration Potential and Preference of Adolescents
Authors: Wu Linjia , Dong Qidi , Luo Shixian , Jiang Wenyuan , Hao Ming , Chen Qibing
Published: December 2021

City green space can promote people’s health and aesthetic satisfaction; however, most extant research focuses on suburban forests and urban parks. Urban landscape forests have important ecological and aesthetic value for urban environments. This study conducted a visual stimulation to examine the impact of four common spatial element combinations in urban landscape forests on teenagers’ recovery potential and preference. The results indicate that urban landscape forests had positive physiological and psychological effects on adolescents, including decreased blood pressure, improved heart rate, reduced anxiety, and improved recovery ability. Diastolic blood pressure relief performance was better among males than females. In addition, a stepwise linear regression analysis was performed to explore the quantitative relationship between spatial elements and recovery and preference values. The results demonstrate that water elements were a significant predictor in the quantitative relationship between spatial elements in landscape forests and restoration and preference values. Terrain, flower, and shrub elements did not have a significant effect on overall restoration and preference values. This study highlights the intervention value of urban landscape forests in promoting the health and well-being of adolescents, with implications for future planning and design of urban landscape forests.
Heritage Tagalog Phonology and a Variationist Framework of Language Contact
Authors: Umbal Pocholo , Nagy Naomi
Published: December 2021

Heritage language variation and change provides an opportunity to examine the interplay of contact-induced and language-internal effects while extending the variationist framework beyond monolingual speakers and majority languages. Using data from the Heritage Language Variation and Change in Toronto Project, we illustrate this with a case study of Tagalog (r), which varies between tap, trill, and approximant variants. Nearly 3000 tokens of (r)-containing words were extracted from a corpus of spontaneous speech of 23 heritage speakers in Toronto and 9 homeland speakers in Manila. Intergenerational and intergroup analyses were conducted using mixed-effects modeling. Results showed greater use of the approximant among second-generation (GEN2) heritage speakers and those that self-report using English more. In addition, the distributional patterns remain robust and the approximant appears in more contexts. We argue that these patterns reflect an interplay between internal and external processes of change. We situate these findings within a framework for distinguishing sources of variation in heritage languages: internal change, identity marking and transfer from the dominant language.
Microplastics in the Food Chain
Authors: Cverenkárová Klára , Valachovičová Martina , Mackuľak Tomáš , Žemlička Lukáš , Bírošová Lucia
Published: December 2021

Currently, microplastics represent a widespread contamination found in almost every part of the environment. The plastic industry has generated waste since the 1950s, which unfortunately now counts in the millions. The largest share of plastic consumption is used to produce packaging materials, including those applied in the food industry. The versatility of plastic materials is mainly due to their lightness, flexibility, strength, and persistence. Although plastic materials are widely used due to their beneficial properties, contamination of the environment with microplastics and nanoplastics is an emerging problem worldwide. This type of contamination is endangering animal life and thus also the food chain and public health. This review summarizes the knowledge about microplastics in the food chain. The effect of microplastics on the food chain has been particularly studied in marine organisms, and research deals less with other food commodities. Therefore, based on the studied literature, we can conclude that the issue is still not sufficiently examined, and should be paid more attention to maintain the health of the population.
Mitochondria and Their Relationship with Common Genetic Abnormalities in Hematologic Malignancies
Authors: Czegle Ibolya , Gray Austin L. , Wang Minjing , Liu Yan , Wang Jun , Wappler-Guzzetta Edina A.
Published: December 2021

Hematologic malignancies are known to be associated with numerous cytogenetic and molecular genetic changes. In addition to morphology, immunophenotype, cytochemistry and clinical characteristics, these genetic alterations are typically required to diagnose myeloid, lymphoid, and plasma cell neoplasms. According to the current World Health Organization (WHO) Classification of Tumors of Hematopoietic and Lymphoid Tissues, numerous genetic changes are highlighted, often defining a distinct subtype of a disease, or providing prognostic information. This review highlights how these molecular changes can alter mitochondrial bioenergetics, cell death pathways, mitochondrial dynamics and potentially be related to mitochondrial genetic changes. A better understanding of these processes emphasizes potential novel therapies.
Credibility of the Neutrophil-to-Lymphocyte Count Ratio in Severe Traumatic Brain Injury
Authors: Siwicka-Gieroba Dorota , Dabrowski Wojciech
Published: December 2021

Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality worldwide. The consequences of a TBI generate the activation and accumulation of inflammatory cells. The peak number of neutrophils entering into an injured brain is observed after 24 h; however, cells infiltrate within 5 min of closed brain injury. Neutrophils release toxic molecules including free radicals, proinflammatory cytokines, and proteases that advance secondary damage. Regulatory T cells impair T cell infiltration into the central nervous system and elevate reactive astrogliosis and interferon-γ gene expression, probably inducing the process of healing. Therefore, the neutrophil-to-lymphocyte ratio (NLR) may be a low-cost, objective, and available predictor of inflammation as well as a marker of secondary injury associated with neutrophil activation. Recent studies have documented that an NLR value on admission might be effective for predicting outcome and mortality in severe brain injury patients.
Dynamometric Investigation on Airborne Particulate Matter (PM) from Friction Materials for Automobile: Impact of Abrasive and Lubricant on PM Emission Factor
Authors: Kim Sung-Hun , Jeong Mu Hyeok , Kim Jaegyeom , Shim Wooyoung , Kwon Sung-Uk , Lee Jung-Ju , Huh Seung Hun , Pee Jae-Hwan , Kim Jong-Young
Published: December 2021

Reduction of non-exhaust airborne particulate matter (PM), leading to adverse effects in respiratory system, is an urgent task. In this work, we evaluated the impact of raw materials in friction materials on PM emission due to brake wear for passenger vehicle. Time- and temperature-dependent measurements using dynamometer were made for low-steel friction materials with varied abrasives and lubricant(graphite). The brake emission factor (BEF) for graphite of varied sizes ranged from 6.48 to 7.23 mg/km/vehicle. The number concentration indicates that smaller graphite (10 μm) produces more nano-sized particles than larger size (700 μm) by >50%. Depending on abrasives, BEF was found to be varied as large as by three-times, ranging from 4.37 to 14.41 mg/km/vehicle. As hardness of abrasive increases (SiC > Al2O3 > ZrSiO4), higher BEF was obtained, suggesting that abrasive wear directly contributes to emissions, evidenced by surface topology. Temperature-dependent data imply that particle emission for SiC abrasive is initiated at lower speed in WLTC cycle, where disc temperature (Tdisc) is ~100 °C, than that for ZrSiO4 (Tdisc >120 °C). Analysis of wear debris suggests that larger micron-sized particles include fragmented Fe lumps from disc, whereas smaller particles are, in part, formed by combination of oxidation and aggregation of nano-sized particles into small lumps.
An Efficient Synthesis of Novel 3-[(Heteroaryl-2-ylimino)-methyl]-4-hydroxy-chromen-2-ones and Analogue of Tetrazole Derivatives and Their Antibacterial Activity
Authors: Hoti Ramiz , Ismaili Hamit , Thaçi Veprim , Mulliqi-Osmani Gjyle , Pllana-Zeqiri Malësore , Bytyqi Agon
Published: December 2021

Synthesis of a series of the substituted [(pyridinyl and pyrimidin-2-ylimino)-ethyl]-4-hydroxy-chromen-2-ones and their tetrazole derivates is presented in this study. By catalytic condensation of 4-hydroxy-3-acetylcoumarine 2 and 2-aminopyridines 3(a-d), 3-[(pyridin-2-ylimino)-ethyl]-4-hydroxy-chromen-2-ones 4(a-d) are synthesized in high yield. During the condensation reaction of 2 and 4-amino-2,6-dihydroxypyrimidine 3e, 3-[1-(2,6-Dihydroxy-pyrimidin-4-ylimino)-ethyl]-4-hydroxy-chromen-2-one 4e as condensation products is synthesized. In following series, by cyclization reactions of compounds 4 (a-e) with sodium azide, analogue 3-substituted pyridin-2-yl and pyrimidin-2-yl-5-methyl-2,5-dihydro-1H-tetrazol-5-yl]-4-hydroxy-chromen-2-one 5(a-e) are synthesized the products. Structural characterization of the synthesized products is done on the basis of spectrometric data. Antibacterial activity of the compounds 4(a-e) and 5(a-e) against S. aureus, E. coli and Klebsiella was examined by measuring the inhibition zones around the disks marked with the corresponding products solution. The impact of substitutions in antimicrobial is also explored. Compounds with polar groups have shown significant antibacterial activity against these microorganisms.
Progress and Current Limitations of Materials for Artificial Bile Duct Engineering
Authors: Sun Qiqi , Shen Zefeng , Liang Xiao , He Yingxu , Kong Deling , Midgley Adam C. , Wang Kai
Published: December 2021

Bile duct injury (BDI) and bile tract diseases are regarded as prominent challenges in hepatobiliary surgery due to the risk of severe complications. Hepatobiliary, pancreatic, and gastrointestinal surgery can inadvertently cause iatrogenic BDI. The commonly utilized clinical treatment of BDI is biliary-enteric anastomosis. However, removal of the Oddi sphincter, which serves as a valve control over the unidirectional flow of bile to the intestine, can result in complications such as reflux cholangitis, restenosis of the bile duct, and cholangiocarcinoma. Tissue engineering and biomaterials offer alternative approaches for BDI treatment. Reconstruction of mechanically functional and biomimetic structures to replace bile ducts aims to promote the ingrowth of bile duct cells and realize tissue regeneration of bile ducts. Current research on artificial bile ducts has remained within preclinical animal model experiments. As more research shows artificial bile duct replacements achieving effective mechanical and functional prevention of biliary peritonitis caused by bile leakage or obstructive jaundice after bile duct reconstruction, clinical translation of tissue-engineered bile ducts has become a theoretical possibility. This literature review provides a comprehensive collection of published works in relation to three tissue engineering approaches for biomimetic bile duct construction: mechanical support from scaffold materials, cell seeding methods, and the incorporation of biologically active factors to identify the advancements and current limitations of materials and methods for the development of effective artificial bile ducts that promote tissue regeneration.
Effect of Gd2O3 Addition on the Microstructure and Properties of Gd2O3-Yb2O3-Y2O3-ZrO2 (GYYZO) Ceramics
Authors: Gao Pei-Hu , Zeng Sheng-Cong , Jin Can , Zhang Bo , Chen Bai-Yang , Yang Zhong , Guo Yong-Chun , Liang Min-Xian , Li Jian-Ping , Li Quan-Ping , Lu Yong-Qing , Jia Lu , Zhao Dan
Published: December 2021

Gd and Yb elements have high chemical stability, which can stabilize the solid solution in ZrO2. Gd2O3 and Yb2O3 have high melting points, and good oxidation resistance in extreme environments, stable chemical properties. Therefore, Gd2O3 and Yb2O3 were added to ZrO2 to stabilize oxides, improve the high temperature stability, and effectively decrease the thermal conductivity at high temperature. In this work, 5 wt% Yb2O3 and 5 wt%, 10 wt%, 15 wt% Gd2O3 were doped into 8 wt% Y2O3 stabilized ZrO2 (8YSZ) powders as thermal barrier coating materials, and sintered at 1650 °C for 6 h, 12 h, 24 h. The effects of Gd2O3 addition on the microstructure, density, thermal conductivity, hardness, and fracture toughness of Gd2O3-Yb2O3-Y2O3-ZrO2 (GYYZO) bulk composite ceramics were investigated. It was found that the densification of the 8YSZ bulk and GYYZO bulk with 15 wt% Gd2O3 reached 96.89% and 96.22% sintered at 1650 °C for 24 h. With the increase of Gd2O3 addition, the hardness, elastic modulus and fracture toughness of the GYYZO bulk increased and the thermal conductivity and thermal expansion coefficient of the GYYZO bulk decreased. GYYZO bulk with 15 wt% Gd2O3 sintered at 1650 °C for 24h had the highest hardness, elastic modulus and fracture toughness of 15.61 GPa, 306.88 GPa, 7.822 MPa·m0.5, and the lowest thermal conductivity and thermal expansion coefficient of 1.04 W/(m·k) and 7.89 × 10−6/°C at 1100 °C, respectively. The addition of Gd2O3 into YSZ could not only effectively reduce the thermal conductivity but also improve the mechanical properties, which would improve the thermal barrier coatings’ performances further.
Effect of Cooling Rate during Glazing on the Mechanical and Optical Properties of Monolithic Zirconia with 3 mol% Yttria Content
Authors: Cho Mi-Hyang , Seol Hyo-Joung
Published: December 2021

Glazing is the final heat treatment process in the manufacturing of a monolithic zirconia prosthesis. Herein, the effect of cooling rate during zirconia glazing was investigated. A 3 mol% yttria-stabilized tetragonal zirconia polycrystal was glazed at the general cooling rate suggested by the manufacturer, as well as at higher and lower cooling rates, and the differences in flexural strength, hardness, optical properties, and crystal structure were evaluated. A higher cooling rate did not affect the flexural strength, hardness, grain size, optical properties, or crystal structure; however, the Weibull modulus decreased by 1.3. A lower cooling rate did not affect the flexural strength, optical properties, or crystal structure; however, the Weibull characteristic strength increased by 26.7 MPa and the Weibull modulus increased by 0.9. The decrease in hardness and the increase in grain size were statistically significant; however, the numerical differences were negligible. This study revealed that a lower cooling rate provides more reliable flexural strength. Therefore, glazing can proceed at a general cooling rate, which takes 3–4 min; however, glazing at a lower cooling rate will provide a more consistent flexural strength if desired, despite being time-consuming.
Analysis and Optimization of Dimensional Accuracy and Porosity of High Impact Polystyrene Material Printed by FDM Process: PSO, JAYA, Rao, and Bald Eagle Search Algorithms
Authors: Chandrashekarappa Manjunath Patel Gowdru , Chate Ganesh Ravi , Parashivamurthy Vineeth , Kumar Balakrishnamurthy Sachin , Bandukwala Mohd Amaan Najeeb , Kaisar Annan , Giasin Khaled , Pimenov Danil Yurievich , Wojciechowski Szymon
Published: December 2021

High impact polystyrene (HIPS) material is widely used for low-strength structural applications. To ensure proper function, dimensional accuracy and porosity are at the forefront of industrial relevance. The dimensional accuracy cylindricity error (CE) and porosity of printed parts are influenced mainly by the control variables (layer thickness, shell thickness, infill density, print speed of the fused deposition modeling (FDM) process). In this study, a central composite design (CCD) matrix was used to perform experiments and analyze the complete insight information of the process (control variables influence on CE and porosity of FDM parts). Shell thickness for CE and infill density for porosity were identified as the most significant factors. Layer thickness interaction with shell thickness, infill density (except for CE), and print speed were found to be significant for both outputs. The interaction factors, i.e., shell thickness and infill density, were insignificant (negligible effect) for both outputs. The models developed produced a better fit for regression with an R2 equal to 94.56% for CE, and 99.10% for porosity, respectively. Four algorithms (bald eagle search optimization (BES), particle swarm optimization (PSO), RAO-3, and JAYA) were applied to determine optimal FDM conditions while examining six case studies (sets of weights assigned for porosity and CE) focused on minimizing both CE and porosity. BES and RAO-3 algorithms determined optimal conditions (layer thickness: 0.22 mm; shell thickness: 2 mm; infill density: 100%; print speed: 30 mm/s) at a reduced computation time equal to 0.007 s, differing from JAYA and PSO, which resulted in an experimental CE of 0.1215 mm and 2.5% of porosity in printed parts. Consequently, BES and RAO-3 algorithms are efficient tools for the optimization of FDM parts.