bluuebunny/crossref_metadata_2025 huggingface dataset:
Formulated algae-based food with low polyphenol content and its effect on the feeding preference of juvenile blue abalone Haliotis fulgens
Authors: Villa-Arce Miguel Ángel , Muñoz-Ochoa Mauricio , Hernández-Carmona Gustavo , Mendoza-Cruz Margarita , Godínez-Pérez Carlos Alonso , Vélez-Arellano Nurenskaya
Published: March 2023

The objective of this study was to evaluate the effect of polyphenol reduction in a food formulated with Eisenia arborea and its effect on the feeding preference of the abalone Haliotis fulgens through multiple selection tests. Two foods were formulated: one without polyphenol reduction (EA01) and one with polyphenol reduction (EA02). Rehydrated E. arborea (ER03) was used as the control food. The polyphenol content was quantified in EA01 and EA02, and the stability and hardness of all three foods were measured at 24 h. Food preference was evaluated through attraction and consumption tests on day 1, 6, and 12. The polyphenol concentration was reduced by 41% in EA02 (13.9 mg GAE/g) compared to that of EA01 (33.3 mg GAE/g). Both formulated foods showed 88% stability and hardness values > 680 g cm− 2, which were greater than those of the control (ER03, 66% and 285 g cm− 2, respectively). Abalone were more attracted to EA02 and ER03 on day 1, 6, and 12 than to ER03 on the same days. A similar trend was observed with consumption. EA02 and ER03 were the most consumed foods (> 6 g/day) throughout the experiment, and no significant differences in consumption were observed between these foods. On the other hand, juvenile H. fulgens showed a greater attraction to and consumption of EA02 (reduced polyphenol content) than EA01 (no reduction in polyphenol content). This allows us to conclude that EA02 can replace rehydrated algae as a suitable food source for juvenile H. fulgens.
Twin primes as a consequence of Goldbach's conjecture
Authors: Nunez Hector
Published: March 2023

The binary Goldbach conjecture asserts that every even integer greater than 2 can be expressed as the sum of two primes. In addition, the ternary Goldbach conjecture states that every odd integer greater than 5 is the sum of three primes. Both conjectures originated in an exchange of letters between Leonhard Euler and Christian Goldbach in 1742. We claim that both Goldbach problems are valid with multiple partitions for every integer greater than 12. We approached the binary Goldbach problem by the second principle of mathematical induction. Based on the inductive hypothesis, we found that every even integer within a finite interval can be expressed as the difference between two primes. This fact allowed us to tackle the inductive step advantageously. Once both Goldbach problems were proved, we were empowered to claim that every even integer can be written infinitely many ways, as the difference between two primes, where the twin-prime conjecture is a particular case.
MSC Classification: 11P32 , 11N05
Dissimilar Joint Welding Through Friction Stir Techniques: Mechanical and Microstructural Properties of AA2198-T8 & AA2024-T3
Authors: Samir Ahmed Anwar , Jalal Shawnim R , Mulapeer Mohammedtaher M
Published: March 2023

Friction stir welding is used to evaluate the metallurgical and material characteristics of AA2198-T8 and AA2024-T3 welds. One of the most often utilised high-strength aluminium alloys in the aerospace industry is AA2024-Tx. The latest generation of aluminium lithium alloys, AA2198-T8, just replaced AA2024-T3. Yet, sound weld methods with the highest mechanical qualities have yet to be adequately characterised. These two materials were selected and joined through two techniques. The first is a single side friction stir weld, while the second is a double side friction stir weld. This technique was used to create specimens by holding them side by side. After the stirring, the hybrid joint was created by taking spindle speeds of 580 RPM and travel speeds of 36, 76, 102, 146, and 216 mm/min into account. The tool angle and dwell duration evaluated in this study were 2o and 20 seconds, respectively. Fabricated samples were then sectioned in accordance with industry standards. Tests to determine factors like as tensile strength, impact load, and microstructures at various temperature zones. The results show that the maximum joint efficiency for a double-side friction stir welded connection at 102 mm/min was 96%.
Hybrid VMAT-3DCRT as Breast Cancer Treatment Improvement Tool
Authors: voyant cyril , pinpin morgane , leschi delphine , prapant séverine , savigny francoise , acquaviva marie-aimée
Published: March 2023

Radiation therapy is an important tool in the treatment of breast cancer and can play a crucial role in improving patient outcomes. For breast cancer, if the technique has been for a long time the use of 3DCRT, clinicians have seen the management evolve greatly in recent years. Field-in-field and IMRT approaches and more recently dynamic arctherapy are increasingly present. All of these approaches are constantly trying to improve tumour coverage and to preserve organs at risk by minimising the doses delivered to them. If arctherapy allows a considerable reduction of high doses received by healthy tissues, no one can deny that it also leads to an increase of low doses in tissues that would not have received any with other techniques. We propose a hybrid approach combining the robustness of the 3DCRT approach and the high technicality and efficiency of rctherapy. Statistical tests (ANOVA, Wilcoxon, determination coefficient, ROC, etc.) allow us to draw conclusions about the possibility of using the hybrid approach in certain cases (right breast, BMI > 23, age > 48, target volume > 350cc, etc.). Depending on the breast laterality and patients morphological characteristics, hybridization may prove to be a therapeutic tool of choice in the management of breast cancer in radiotherapy.
The impact of a patient-centered care pathway for patients treated with oral anticancer drugs: a multicenter pre-post-test study in Flanders
Authors: Kenis Ilyse , Hecke Ann , Foulon Veerle
Published: March 2023

Purpose
In the Collaborative Network To Take Responsibility for Oral Anticancer Therapy (CONTACT) project, an evidence-based and patient-centered care pathway was implemented in 12 oncology departments in Flanders. The care pathway was developed in co-creation by an interdisciplinary project team, and tailored to the local hospital context. In this study, the impact of the care pathways on quality of patient-centered care (PCC) and other patient outcomes was investigated.
Methods
A pre-post-test study was performed in nine of the participating oncology departments. The primary outcome was quality of PCC. Furthermore, level of patient self-management, medication adherence, satisfaction with information about the OACD, and quality of life were measured as secondary outcomes. Linear mixed models were used to investigate differences in outcomes between the pre- and post-test group.
Results
Quality of PCC, as well as all secondary outcomes improved after implementation of the care pathway. However, the changes in pre- and post-test scores were not significant. The overall quality of PCC increased from 3.72 to 3.88, measured on a five-point Likert scale (p = 0.124).
Conclusion
This study showed small, however not significant, improvements in the quality of PCC and other patient outcomes. The lack of significant changes can be attributed to the complexity of the care pathway development, poor or unstable implementation of the care pathway, and limited changes in follow-up care. More insight in the actual implementation of the care pathway and potential contextual factors influencing its effect is needed to help understand the outcomes of this pre-post-test study.
Application of machine learning algorithm in prediction of lymph node metastasis in patients with intermediate and high-risk prostate cancer
Authors: wang xiangrong , zhang xiangxiang , li hengping , zhang mao , liu yang , li xuanpeng
Published: March 2023

Purpose
This study aims to establish the best prediction model of lymph node metastasis (LNM) in patients with intermediate and high-risk prostate cancer (PCa) through machine learning (ML), and provide the guideline of accurate clinical diagnosis and precise treatment for clinicals.
Methods
A total of 24,470 patients with intermediate and high-risk PCa were included in this study. Multivariate logistic regression model was used to screen the independent risk factors of LNM. At the same time, six algorithms, namely, random forest (RF), naive bayesian classifier (NBC), xgboost (XGB), gradient boosting machine (GBM), logistic regression (LR) and decision tree (DT) are used to establish risk prediction models. Based on the best prediction performance of ML algorithm, a prediction model is established, and the performance of the model is evaluated from three aspects: area under curve (AUC), sensitivity and specificity.
Results
In multivariate logistic regression analysis, T stage, PSA, Gleason score and bone metastasis were independent predictors of LNM in patients with intermediate and high-risk PCa. By comprehensively comparing the prediction model performance of training set and test set, GBM model has the best prediction performance (F1 score = 0.838, AUROC = 0.804). Finally, we developed a preliminary calculator model that can quickly and accurately calculate the regional LNM in patients with intermediate and high-risk PCa.
Conclusion
T stage, PSA, Gleason and bone metastasis were independent risk factors for predicting LNM in patients with intermediate and high-risk PCa. The prediction model established in this study performs well, however, the GBM model is the best one.
System management of irrigation under climate change conditions for determining the crop water demand and solutions for the water-saving
Authors: Kovalchuk Volodymyr , Yatsiuk Mykhailo , Kovalchuk Pavlo , Balykhina Hanna , Demchuk Olena , Voitovych Oleksandr
Published: March 2023

When droughts occur and temperatures rise, water demand increases when growing crops. For these conditions, system management of irrigation is proposed as a system approach, which ensures the efficient use of water resources and their savings. A method for estimating the increase in water resources under climate change is proposed. The method is based on a comparison of water balance deficits, ranked by estimated moisture supply of the year, at two time intervals: in recent 30 years and in past decades before (1960–1990 and 1991–2021). System management of irrigation combines instrumental and calculative methods. Instrumental methods using an automated tensiometer and Watermark provide feedback on the daily soil moisture status in the field. According to the calculative methods, irrigation forecasting is carried out using Internet weather services and optimal control is carried out on a sliding interval. An algorithm of the instrumental-calculative method is proposed within system irrigation management. When the algorithm is combined with biologically optimal irrigation regimes, the effective use of available water is achieved. When using the parameters of water-saving irrigation regimes, water resources are saved up to 30%, which is important in a changing climate.
A ring laser interferometer observation of global mass transport phenomena
Authors: Schreiber Karl , Kodet Jan , Hugentobler Urs , Kluegel Thomas , Wells Jon-Paul
Published: March 2023

An exact knowledge of the instantaneous Earth rotation rate is indispensable for accurate navigation and point positioning. Fluctuations in the `Length of sidereal Day' (LoD) are caused by a momentum exchange between the fluids of the Earth, namely the atmosphere, hydrosphere and cryosphere and the solid Earth. Since a multitude of very different globally distributed and independent mass transport phenomena are involved, the resultant effect on the Earth rotation is not predictable and has to be measured continuously. Here we report successful observations of the minute variations in the rotation rate of the Earth ΔΩe at the level of 5 ppb, by an inertial self-contained measurement technique. Our active optical ring laser interferometer `G' is operated in the Sagnac configuration and is rigidly strapped down to the Earth's crust. This large scale gyroscope integrates over one hour for each data point, increasing the data rate of LoD estimates by more than one order of magnitude, thus enlarging the measurement bandwidth. It is emphasized that a single local sensor, namely a large ring laser interferometer, is now able to measure effects which previously required entire global networks of GNSS receivers and VLBI interferometers, which themselves then provide a single measurement per day.
Inhibition of discoidin domain receptor (DDR)-1 with nilotinib induces autophagy and reduces inflammation and vascular fibrosis in Alzheimer’s disease
Authors: Stevenson Max , Varghese Rency , Hebron Michaeline , Liu Xiaoguang , Ratliff Nick , Smith Amelia , Turner R. Scott , Moussa Charbel
Published: March 2023

Discoidin Domain Receptor (DDR)-1 is activated by collagen. Nilotinib is a tyrosine kinase inhibitor that is FDA-approved for leukemia and potently inhibits DDR-1. Individuals diagnosed with mild-moderate Alzheimer’s disease (AD) treated with nilotinib (versus placebo) for 12 months showed reduction of amyloid plaque and cerebrospinal fluid (CSF) amyloid, and attenuation of dopamine catabolism and hippocampal volume loss. Unbiased next generation whole genome miRNA sequencing from CSF of AD patients was performed and miRNAs were matched with their corresponding mRNAs using gene ontology. Changes in CSF miRNAs were confirmed via measurement of CSF DDR1 activity, plasma levels of AD biomarkers, and breeding DDR1 knockout mice with a transgenic model of CNS vascular amyloidosis. Approximately 1050 miRNAs are detected in the CSF but only 17 miRNAs are specifically altered between baseline and 12-months treatment with nilotinib versus placebo. Treatment with nilotinib significantly reduces collagen and DDR1 gene expression (upregulated in AD brain), in association with inhibition of CSF DDR1. Pro-inflammatory cytokines, including interleukins and chemokines are reduced along with caspase-3 gene expression. Specific changes in vesicular transport, including the neurotransmitters dopamine and acetylcholine, and autophagy genes, including ATGs, indicate facilitation of autophagic flux and cellular trafficking. Specific genes that indicate vascular fibrosis, e.g. collagen and TGFs and vascular integrity (TIMPs) are altered by DDR1 inhibition with nilotinib. DDR1 knockout mice crossed with a model of vascular amyloidosis show similar reductions of collagen 4 levels and blood vessel thickness. Inhibition of DDR1 with nilotinib may be safe and effective adjunctive treatment strategy involving an oral drug that enters the CNS and adequately engages its target. DDR1 inhibition with nilotinib exhibits multi-modal effects not only on amyloid and tau clearance and dopamine neurotransmission but also on anti-inflammatory markers that may reduce cerebrovascular fibrosis.
Dynamic Carpooling and Repositioning for Ridehailing Services with Mixed
Authors: Ngo Huan Hoang , Mishra Sabyasachee
Published: March 2023

In recent years, ridesharing has been an important part of the urban transportation system with the advancement of Transportation Network Companies such as Uber and Lyft since they can leverage technology and connectivity to enhance system performance. However, the system is still hindered by the imbalance between supply and demand in spatial and temporal dimensions. One plausible solution is the introduction of autonomous electric taxi (AET) and the central controller can preemptively and optimally reposition taxis to high demand area. In addition, the controller needs to simultaneously consider the need of human driven taxi (HV) because the near future adoption of AET is likely to include both types. This paper develops a framework namely RL-AET for dispatching single and carpooling taxi trips, repositioning, and recharging a fleet of autonomous electric taxi with a multi-objective of minimizing customer and system-oriented costs. The framework makes use of optimization models and minimum weight perfect matching for dispatching single and carpooling trips for both AET and HV and a reinforcement learning model for repositioning AET between zones and recharging. An asynchronous solving algorithm is used to ensure the framework is computationally capable of real-world network applications. Our RL-AET framework’s capability is demonstrated on the Chicago Road network with 7,393 links and 2,514 nodes and compared with the Baseline Model strategy from traditional practices. The carpooling trip model helps reducing the number of taxis needed by 58% with an average capacity of 2.3 demands per trip. The repositioning model increases the number of matchings by three-fold compared to the Baseline. Ultimately, the proposed framework is able to reduce the total weekly wait time and number of cancelled trips by 75% and 72% respectively. This study can benefit ridesharing providers’ in decreasing their operational cost and the travelers’ interest in decreasing their waiting and pickup time.
Impact of Number and Position of Tooth Loss in Quality of Life: The Chilean National Health Survey 2016- 2017
Authors: Buratovic Juan Pablo Vargas , Tagle Elizabeth Lopez , Martinez Cynthia Cantarutti , Mococain Claudio Carrasco , Ferrer Francisco Moreno , Paiva Claudia Veliz , Maira Paula Margozzini , Torres Beatriz Mellado , Borroto Duniel Ortuno
Published: March 2023

Purpose
Considering that oral conditions can affect Health-Related Quality of Life (HRQoL), this study aimed to evaluate the impact of tooth loss on HRQoL and Oral Health-Related Quality of Life (OHRQoL) in Chilean adults who participated in the 2016–2017 National Health Survey (ENS 2016–2017).
Methods
This study included 5473 individuals. The EQ-5D questionnaire was used to measure HRQoL. OHRQoL was evaluated through one general question (GQ/ENS) and five specific questions (SQ/ENS). One-way ANOVA was performed to identify differences in the number of teeth. Multinomial logistic regressions were used to examine the odds ratio (OR) with their respective confidence intervals of 95% for anterior tooth loss.
Results
In the EQ-5D "self-care" question, the number of teeth decreased from 20.18 teeth (se 0.13) in G1 to 6.43 (se 1.38) in G3 individuals. In GQ/ENS, in individuals with upper anterior tooth loss, the OR for "Poor" was 2.26 (CI 95% 1.04–4.94) and increased to 2.97 (CI 95% 0.85–10.32) for "Very poor" OHRQoL. In SQ/ENS, upper anterior tooth loss represented an OR of 2.57 (CI 95% 1.30–5.05) for "always" being interfered by teeth or prostheses in their social relationships.
Conclusions
A lower number of remaining teeth was associated with lower HRQoL scores in all EQ-5D dimensions and poor OHRQoL according to GQ/ENS and SQ/ENS questionnaires. The anterior tooth loss was less associated with lower HRQoL, but this condition highly impacted the OHRQoL.
Use of Survival-SVM combined with Random-Survival-Forest to predict the survival of nasopharyngeal carcinoma patients
Authors: Xiao Zhiwei , Song Qiong , Wei Yuekun , Fu Yong , Huang Daizheng , Huang chao
Published: March 2023

Background:
The Cox regression model is not sufficiently accurate to predict the survival prognosis of nasopharyngeal carcinoma (NPC) patients. It is impossible to calculate and rank the importance of impact factors due to the low predictive accuracy of the Cox regression model. So, we developed a system. Using the SEER database data on NPC patients, we proposed the use of RSF and SSVM in machine learning methods to develop a survival prediction system specifically for NPC patients. This approach aimed to make up for the insufficiency of the Cox regression model. We also used the COX regression model to validate the development of the nomogram and compared it with machine learning methods.
Methods:
A total of 1683 NPC patients were extracted from the SEER database from January 2010 to December 2015. We used R language for modeling work, established the nomogram of survival prognosis of NPC patients by COX regression model, ranked the correlation of influencing factors by Random-Survival-Forest model VIMP method, developed a survival prognosis system for NPC patients based on Survival-SVM, and used C-index for model evaluation and performance comparison.
Results:
Although the Cox regression models can be developed to predict the prognosis of NPC patients, their accuracy is lower than that of machine learning methods. When we substituted the data for the Cox model, the C-index for the training set was only 0.740, and the C-index for the test set was 0.721. In contrast, the C index of the Survival-SVM model was 0.785. The C-index of the Random-Survival-Forest model was 0.729. The importance ranking of each variable could be obtained according to the VIMP method.
Conclusion:
The prediction results from the COX model are not as good as those of the Random-Survival-Forest method and Survival-SVM based on the machine learning method. For the survival prognosis of NPC patients, the machine learning method can be considered for clinical application.
Sarcomatoid hepatocellular carcinoma in a chronic hepatitis B infection patient without previous antitumor therapy: a case report and literature review
Authors: Chen Xiaorong , Luo Fang , Zhou Hang
Published: March 2023

Background
Sarcomatoid hepatocellular carcinoma (SHC) is rare. As a subtype of hepatocellular carcinoma (HCC), the clinical manifestations of SHC are similar to those of traditional HCC. Surgical resection is the main treatment, and postoperative adjuvant therapy can prolong the life of patients. However, the prognosis of sarcomatoid hepatocellular carcinoma is worse than that traditional HCC.
Case presentation:
we report a 69-year-old male patient with sarcomatoid hepatocellular carcinoma who was admitted to the hospital because of liver enlargement. Abdominal computed tomography revealed a mass in the right lobe of the liver (6.8 cm*4.8 cm). After middle hepatectomy, sarcomatous hepatocellular carcinoma was confirmed by histopathology and immunohistochemistry, and the patient was treated with transcatheter arterial chemoembolization(TACE) and targeted drugs after surgery. The patient died 26 months after surgery. Furthermore, we summarized the clinical, pathological, imaging and treatment of this type of tumor to further understand this solid tumor.
Conclusion
Sarcomatoid hepatocellular carcinoma is a rare subtype of hepatocellular carcinoma, Immunohistopathology is the main way to confirm the diagnosis. Due to the high malignancy and recurrence and metastasis rates of SHC, definite pathological diagnosis, suitable postoperative adjuvant therapy and strict follow-up management are helpful to improve the progression-free survival and survival rate of patients with SHC.
Bounded Solutions for Anisotropic Degenerate Parabolic Problems with Singular Term
Authors: Zaater Wahiba , Khelifi Hichem
Published: March 2023

Note: Please see pdf for full abstract with equations.
In this paper, we study the existence result of bounded solutions to a nonlinear anisotropic parabolic equations with degenerate coercivity, and the singular term in the right hand side. The model problem is \begin{equation*} \left\{\begin{array}{ll} \frac{\partial u}{\partial t}-\sum_{i=1}^{N}D_{i} \left(\frac{u^{p_{i}-1}(1+D u)^{-1}D u+\vert D u\vert^{p_{i}-2}D u}{(1+\vert u\vert)^{\theta}}\right)=\frac{f}{u^{\gamma}} & \hbox{in}\;\;Q, \\ u(x,0)=0 & \hbox{on}\;\; \Omega,\\ u =0 & \hbox{on}\;\; \Gamma, \end{array} \right. \end{equation*} where $\Omega$ is a bounded open subset of $\mathbb{R}^{N}$ $N\geq2$, $T>0$, $2\leq p_{i}
\frac{N}{\overline{p}}+1$ ($\overline{p}$ defined in \eqref{0001}) and $Q=\Omega\times(0,T)$. The main idea in the proof is based on a Stampacchia's lemma with a good choice of test function that enables us to obtain a priori estimates.
Mathematics Subject Classification (2010). 35K65; 35K55; 35B45; 35B65.
Sternal closure with sandwiched three-piece bioresorbable mesh reduces postoperative hemorrhage: a retrospective study
Authors: Yokoyama Yasutaka , Yamamoto Taira , Oyama Tetsuma , Lee Jiyoung , Machida Yoichiro , Endo Daisuke , Sato Yuichiro , Dohi Shizuyuki , Amano Atsushi , Tabata Minoru
Published: March 2023

Background: Median sternotomy is the most performed procedure in cardiac surgery; however, sternal bleeding remains a problem. This study aimed to investigate whether sternal reconstruction using a sandwiched three-piece bioresorbable mesh plate can prevent postoperative bleeding more than a bioresorbable pin.
Methods: Patients (n = 218) who underwent median sternotomy were classified according to whether a sandwiched three-piece bioresorbable mesh plate and wire cerclage (group M, n = 109) or a bioresorbable pin and wire cerclage (group P, n = 109) was used during sternal reconstruction. The causes of postoperative bleeding and computed tomography data were analyzed and compared between the groups.
Results: The preoperative patient characteristics did not significantly differ between the groups. However, the amount of bleeding at 6 h postoperatively was lower in group M than in group P (235 ± 147 vs. 284 ± 175 mL, p = 0.0275). Chest reopening, intubation time, and length of intensive care unit and hospital stays did not differ between the groups. Evaluation for sternal and substernal hematoma on postoperative day 5 using computed tomography showed sternal displacement in 4 (4%) and 22 (20%) patients, and substernal hematoma in 9 (8%) and 22 (20%) patients in groups M and P, respectively; the difference was significant. The four-grade evaluation of substernal hematoma based on computed tomography yielded a significantly lower grade for group M than for group P, revealing that the mesh plate was an independent predictor of substernal hematoma prevention.
Conclusion: Sternal fixation with a three-piece bioresorbable mesh plate could prevent postoperative bleeding and substernal hematoma more than sternal fixation with a pin.
Prevalence of pulmonary artery dilation in non-cystic fibrosis bronchiectasis: A CT analysis from a cohort of the US Bronchiectasis and Nontuberculous Mycobacteria Research Registry
Authors: Karamooz Elham , Brixey Anupama G. , Rydzak Chara E. , Primack Steven L. , Markwardt Sheila , Barker Alan F.
Published: March 2023

Although pulmonary artery (PA) dilation is independently associated with significant morbidity and mortality in patients with pulmonary diseases irrespective of diagnosed pulmonary hypertension, its relationship to nontuberculous mycobacteria (NTM) is unknown. To determine the prevalence of PA dilation in patients with NTM-predominant non-CF bronchiectasis, we evaluated the chest computed tomography (CT) scans from 321 patient in the United States based Bronchiectasis and NTM Research Registry. The majority of our cohort had NTM infection. We measured the severity of bronchiectasis using modified Reiff criteria and measured the diameters of the PA and aorta (Ao), with PA dilation defined as a PA:Ao ratio > 0.9. Forty-two patients (13%) were found to have PA dilation. PA dilation was positively associated with the use of supplemental oxygen (p < 0.001), but there was no association between PA dilation and NTM infection.
A Survey on E-Commerce Learning to Rank
Authors: Kabir Md Ahsanul , Hasan Mohammad Al , Mandal Aritra , Tunkelang Daniel , Wu Zhe
Published: March 2023

In e-commerce, ranking the search results based on users’ preference is the most important task. Commercial e-commerce platforms, such as, Amazon, Alibaba, eBay, Walmart, etc. perform extensive and relentless research to perfect their search result ranking algorithms because the quality of ranking drives a user’s decision to purchase or not to purchase a product, directly affecting the profitability of the e-commerce platform. In such a commercial platforms, for optimizing search result ranking numerous features are considered, which emerge from relevance, personalization, seller’s reputation and paid promotion. To maintain their competitive advantage in the market, the platforms do no publish their core ranking algorithms, so it is difficult to know which of the algorithms or which of the features are the most effective for finding the most optimal search result ranking in e-commerce. No extensive surveys of learning to rank (LTR) in the e-commerce domain as such is not yet published. In this work, we survey the existing e-commerce learning to rank algorithms. Besides, we also compare these algorithms based on query relevance criterion on a large real-life e-commerce dataset and provide a quantitative comparison. To the best of our knowledge this is the first such survey which include an experimental comparison among various learning to rank algorithms.
The program of the public broadcaster «Election District» as a way of informing about the candidates
Authors: Mostipan Tetiana
Published: March 2023

Introduction. Ukrainian society suffers from aggressive information influences. Information attacks traditionally increase before elections in Ukraine, when citizens receive and consume masses of information. Presentation of information about the candidate ensures the voter’s right to objective, comprehensive and impartial information, defined by the Election Code.
Relevance of the study. The relevance of the study is determined by the need for a detailed analysis of aspects of informing voters about political candidates at the regional level.
Methodology. The main research method was content analysis, during which 9 programs were studied. The method of description made it possible to outline all the aspects of each of the program releases obtained as a result of the content analysis. Differences in formats and thematic direction of programs were determined by the method of comparison. The method of systematization made it possible to organize the results obtained during the research, the method of generalization – to draw meaningful conclusions of scientific intelligence.
Results. In order to present to the electorate the candidates for the post of mayors of Uzhgorod, Sumy and Chernivtsi, the regional branches of Public broadcaster prepared and aired 12 programs: 9 issues of the project «Electoral district. Local» and 3 – «Electoral district. Debate».The content analysis showed that the programs of all branches contained the following structural components: a videocard of the candidate, self-presentation, questions from the editors of the public, questions from community residents. The programs of the Zakarpattia branch received the fewest views on YouTube video hosting, from 173 to 1090 views. The most are the information products of the Bukovyna broadcaster: one of the releases was viewed by more than 12,000 users.
Conclusions. «Electoral district. Local» and «Electoral district. Debates» became the first projects of regional television, which systematically and in detail provided viewers with information about the candidates, their programs and created a platform for discussion between politicians. We consider the study of discussion programs and other formats implemented by regional branches of the public broadcaster of Ukraine to be promising.
Oxidative stress induced by fluorine in Xanthoria parietina (L.) Th. Fr.
Authors: BENHAMADA Ouahiba , BENHAMADA Nabila , LEGHOUCHİ Essaid
Published: March 2023

In our work we were interested in the toxicity of fluorine on the various parameters of stress: chlorophyll, proteins, and antioxidant system in the lichen Xanthoria parietina (L.) Th. Fr., and for this purpose, lichen thalli were treated by sodium fluoride (NaF) at concentrations of 0, 0.5, 1.0, 5.0 and 10.0 mM, for time scale 0, 24, 48 and 96 h. The analysis results obtained revealed that all the parameters evaluated showed significant variations compared to those of the controls. From the analysis results obtained, it was noted that chlorophyll a (Ca), chlorophyll b (Cb) and total chlorophyll (Ca+b) decreased correlating with exposure times to NaF (r = -0.785, p < 0.001; r = -0.955, p < 0.001; r = -0.899, p < 0.001, respectively), with a significant increase of Ca/b ratio (p = 0.00572**) showing that Cb was more affected than Ca. However, hydrogen peroxide (H2O2) increased (r = 0.949, p < 0.001). In correlation with NaF concentrations, Glutathione (GSH) increased (r = 0.969, p < 0.001), while proteins decreased (r = -0.872, p < 0.001). Furthermore, results showed that catalase activity (CAT) increased correlating with increasing exposure time of X. parietina to increasing concentrations of NaF. Long-term exposure (48 h -96 h) caused a significant decrease in GSH content (p = 0.02*) followed by total destruction at time 96 h.
Zašto je tako malo žena u filozofiji?
Authors: Boršić Luka
Published: March 2023

Nema jednog i jasnog odgovora na pitanje zašto na većini sveučilišta ima više zaposlenih filozofa nego filozofkinja. U prvom dijelu rada analizira se problem povijesne podobrazovanosti žena – što može biti jednostavno objašnjenje za nedostatak žena u povijesti filozofije. Međutim, danas je situacija ipak drukčija, u humanističkim područjima, uključujući i filozofiju, često ima više studentica nego studenata, no to svejedno ne dovodi do značajnog brojčanog izjednačenja muškaraca i žena na višim akademskim pozicijama. Stoga se u prvom dijelu rada govori i o petnaest hipoteza o uzrocima toga stanja, od kojih su neke odbačene, neke vrlo vjerojatne, dok je za potvrđivanje ili odbacivanje nekih potrebno daljnje istraživanje. U drugom dijelu rada ulazi se u problem ideje da tradicionalna filozofija treba »ono žensko« kao »ono drugo« koje je negativno definira. Potonju se poziciju može osporiti sličnim argumentima s pomoću kojih se može odbaciti i esencijalizam.
Uzrokovanje i negativne činjenice
Authors: Prašević Nedžib M.
Published: March 2023

Pitanje odgovornosti u izravnoj je vezi s pojmom uzrokovanja, s obzirom na to da izricanje pravnih i moralnih kvalifikativa u velikoj mjeri ovisi o pojmu uzrokovanja. Problem nastaje kada se u istraživanje uzrokovanja uvedu tzv. »negativne činjenice« koje sudjeluju u artikulaciji iskaza o »propustu«, »nedjelovanju« i »prevenciji«. Zato i jest pitanje mogu li negativne činjenice predstavljati uzrok i/ili posljedicu od izuzetnog značaja. Premda se negativnim činjenicama nerijetko pogrešno i neopravdano pristupa u analogiji s pozitivnim činjenicama, te ih se sukladno tome svrstava pod tzv. »izvorno uzrokovanje«, negativne su činjenice kauzalno inertne. Ovakav odgovor odražava se nepovoljno na praksu formiranja singulamih iskaza o kauzalnim vezama s negativnim činjenicama. Premda, iako je to tako, time se ne obesmišljava uobičajena praksa formulisanja legitimnog uzročnog objašnjenja na kojem se zasnivaju iskazi o propuštanju, nečinjenju i prevenciji.
ULUSLARARASI HUKUKTA DEVLET EGEMENLİĞİNİN HAVA SAHASINA UZANMASININ MEŞRULUĞU
Authors: ÖZDAN Selman
Published: March 2023

Egemenlik kavramı uluslararası hava hukukunda merkezi bir role sahiptir. 1919 Paris ve onun yerine geçen 1944 Chicago Sözleşmelerinin birinci maddelerinde belirtildiği gibi taraf devletlerin kendi ülkeleri üzerindeki hava sahalarında tam ve münhasır egemenliğe sahip olmasına dair yapılan vurgu bu merkezi rolü açıklar niteliktedir. Literatürde karşımıza, hem bu egemenliğin savunulduğu bir hava sahası rejim sistemi çıkmakta hem de bu anlayışın kısmen karşısında olacak şekilde hava sahasında serbestliği savunan bir rejim sistemi çıkmaktadır. Dolayısıyla bu noktada, hangi sistemin çağdaş uluslararası hukukta uygulanması gerektiği değerlendirilmelidir. Bu değerlendirme için hem egemenlik kavramının hem de hava sahasının uluslararası hukuk açısından incelenmeleri elzemdir. Bu makalede öncelikle egemenlik kavramı uluslararası hukuk çerçevesinde izah edilecektir. Akabinde, hava sahasının hukuki statüsü değerlendirilip serbest hava sahası ve ulusal egemenliğe dayalı hava sahası yaklaşımları detaylı olarak incelenecektir. Nihayetinde, uluslararası anlaşmalar nezdinde hava sahasında uygulanması öngörülen rejim tartışmalarına yer vererek devletin kendi ülkesi üzerinde devam eden egemenlik haklarının meşruluğu ve sınırları incelenecektir. Bu bağlamda, çalışmanın temel amacı, uluslararası hukuk açısından devletin ülkesi üzerindeki hava sahasında devam eden egemenliğinin meşruluğunu inceleyip izah etmektir.
Future water security under climate change: a perspective of the Grand River Watershed
Authors: Kaur Baljeet , Shrestha Narayan Kumar , Ghimire Uttam , Paul Pranesh Kumar , Rudra Ramesh , Goel Pradeep , Daggupati Prasad
Published: March 2023

Climate change poses a threat to the water security of the Grand River Watershed (GRW) by altering the precipitation patterns and other weather variables, which affect streamflow and freshwater availability. Therefore, in this study, a Soil and Water Assessment Tool (SWAT) model for the GRW, Ontario, Canada, was used to assess the blue and green water scarcity for future periods for future sustainable management of freshwater resources in the region. The ensemble results predicted a warmer and wetter future for the GRW. The ensemble model result, when considering both emission scenarios and future periods, showed that blue water (BW) is projected to increase by 23–40% while green water storage (GWS) is projected to experience an overall decrease (2–8%). The results suggested that BW may become more scarce compared to green water in the future. The scarcity of BW is primarily due to the projected increase in population growth and water demand in the watershed. Green water scarcity in some regions indicated that changes in irrigation might be needed in the future in some parts of the watershed. The results indicate that the careful planning is essential for future water management in GRW.
O recreio no ensino primário e a educação dos corpos na infância (PARÁ, 1890-1918)
Authors: Pinheiro Welington da Costa , Da Silva Matos Lucília , Do Socorro da Silva Matos Fernandes Roseane
Published: March 2023

O artigo objetiva investigar o recreio e a educação do corpo infantil no ensino primário do estado do Pará, no período de 1890 a 1918, identificando o tempo, os espaços e as atividades presentes na legislação educacional paraense. O estudo se caracteriza como histórico e documental. As fontes centrais utilizadas foram os regulamentos do ensino primário dos anos de 1890, 1903, 1910, 1918 e o regimento interno dos grupos escolares e das escolas isoladas de 1904. Essa documentação foi analisada em diálogo com impressos educacionais do período em tela e autores do campo da história da educação e da infância. A partir da análise das fontes, foi possível identificar que o tempo, o espaço e as atividades do recreio buscavam educar o corpo infantil, a partir da disciplina e formação do físico com a intenção de formar o futuro cidadão republicano, que deveria ser disciplinado, forte e saudável.
Ganaxolone: First FDA-approved Medicine for the Treatment of
Seizures Associated with Cyclin-dependent Kinase-like 5 Deficiency
Disorder
Authors: De Surya K.
Published: March 2023

The neurosteroids progesterone and allopregnanolone control numerous neuroprotective
functions in neural tissues, including inhibition of epileptic seizures and cell
death. Ganaxolone (3α-hydroxy-3β-methyl-5α-pregnan-20-one) (GNX) is the 3β-
methylated synthetic analog of allopregnanolone and an allosteric GABAA positive modulator.
Ganaxolone reduces the frequency of CDD-associated seizures.
WITHDRAWN: Design and Discovery of Lophine Derivatives as Multitargeting Agents by Molecular Docking, ADMET, MD Simulation and Pharmacophore Analysis: A Computational Approach
Authors: Kumar Biswas Shyamal , Sasmal Pujan , Koley Akash , Jana Rimpa , Biswas Jagrity
Published: March 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn from the journal "Combinatorial Chemistry & High Throughput Screening".

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

BENTHAM SCIENCE DISCLAIMER:

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of their article is transferred to the publishers if and when the article is accepted for publication.
Effectiveness and Safety of Traditional Chinese Medicine in Treatment of
Primary Sjögren’s Syndrome Patients: A Meta-analysis
Authors: Liu Hui , Wang Xiaoxin , Liu Weiran , He Guannan , Liang Xiaodong , Bian Yuejuan
Published: March 2023

Backgroud:

Primary Sjögren’s Syndrome (pSS) is an autoimmune disease. It can damage
the salivary and lacrimal glands and is characterized by dry mouth and eye symptoms, which
seriously affects people’s normal life. Both modern medicine and Traditional Chinese medicine
(TCM) have certain effects in treating SS. However, there are different theories about which treatment
is more appropriate.

Objective:

The aim of this research was to compare the efficacy and safety of TCM to Western
Medicine in the treatment of pSS.

Methods:

We collected randomized controlled trials (RCTs) of TCM, integrating traditional Chinese
and Western medicine for the treatment of pSS in Chinese and foreign databases.

Results:

A total of 13 articles were eventually included with 780 cases. The final results were expressed
in odds ratio (OR), mean difference (MD), 95% confidence interval (CI), and overall effect
(z). The effective rate was 86.03% in the TCM group and 67.75% in the western medicine group.
Results of the effective rate were OR = 3.57; 95% CI = 2.44-5.23; z = 6.56; p＜0.00001, ESR were
MD = -6.90; 95% CI = -10.76--3.05; z = 3.51; p = 0.0005＜0.05, Schirmer’s test were MD = 3.39; 95%
CI = 1.92-4.86; z = 4.5; p＜0.00001, salivary flow were MD = 0.62; 95% CI = 0.16-1.07; z = 2.63; p =
0.009＜0.05, and adverse reactions were OR = 0.35; 95% CI = 0.17-0.72; z = 2.84; p = 0.004.

Conclusion:

TCM has a remarkable effect on the treatment of pSS. Among them Yiguanjian decoction
and Liuwei Dihuang decoction were effective prescriptions with the highest frequency of
application. Rehmanniae Radix (Rehmannia glutinosa Libosch.) and Ophiopogonis Radix (Ophiopogon
japonicus (L. f.) Ker-Gawl.) were the most frequently used TCM.
Erythrocyte-based Drug Delivery: How Far from Clinical Application?
Authors: Jiang Yuan , Yuan Yi , Peng Feng , Deng Yi , Ren Chao , Liu Chongzhi , Dong Hai , Tu Tao
Published: March 2023

Erythrocytes are responsible for delivering oxygen throughout the body. They have become suitable drug carriers due to outstanding advantages, such as a long lifespan in circulation, high biosafety, and low immunogenicity. Although erythrocyte-based drug delivery has good application prospects and has become a research hotspot in related fields, the application of erythrocyte-based drug delivery systems is rare in the clinic now. In this review, we discuss the characteristics of erythrocytes, diverse drug-loading approaches, and research progress of erythrocyte-based drug delivery systems. Finally, we explore the challenges of erythrocyte-based drug delivery in clinical application.
Measuring Brain Temperature in Youth Bipolar Disorder Using a Novel
Magnetic Resonance Imaging Approach: A Proof-of-concept Study
Authors: Zou Yi , Heyn Chinthaka , Grigorian Anahit , Tam Fred , Andreazza Ana Cristina , Graham Simon J. , Maclntosh Bradley J. , Goldstein Benjamin I.
Published: March 2023

Background:

There is evidence of alterations in mitochondrial energy metabolism and cerebral
blood flow (CBF) in adults and youth with bipolar disorder (BD). Brain thermoregulation is
based on the balance of heat-producing metabolism and heat-dissipating mechanisms, including CBF.

Objective:

To examine brain temperature, and its relation to CBF, in relation to BD and mood symptom
severity in youth.

Methods:

This study included 25 youth participants (age 17.4 ± 1.7 years; 13 BD, 12 control group
(CG)). Magnetic resonance spectroscopy data were acquired to obtain brain temperature in the left anterior
cingulate cortex (ACC) and the left precuneus. Regional estimates of CBF were provided by arterial
spin labeling imaging. Analyses used general linear regression models, covarying for age, sex,
and psychiatric medications.

Results:

Brain temperature was significantly higher in BD compared to CG in the precuneus. A higher
ratio of brain temperature to CBF was significantly associated with greater depression symptom severity
in both the ACC and precuneus within BD. Analyses examining the relationship of brain temperature or
CBF with depression severity score did not reveal any significant finding in the ACC or the precuneus.

Conclusion:

The current study provides preliminary evidence of increased brain temperature in youth
with BD, in whom reduced thermoregulatory capacity is putatively associated with depression symptom
severity. Evaluation of brain temperature and CBF in conjunction may provide valuable insight
beyond what can be gleaned by either metric alone. Larger prospective studies are warranted to further
evaluate brain temperature and its association with CBF concerning BD.
Association of a Genetic Variant in Chromosome 9p21 with Increased Risk
of Developing Cervical Cancer
Authors: Atabati Mojde , Saber Razieh , Malakuti Parnian , Pourali Ghazaleh , Heydari-Majd Motahareh , Safavi Pegah , Dashti Mohammad , Moghadam Azam Rastgar , Rahmani Farzad , Farazestanian Marjaneh , Behboodi Negin , Mehramiz Mehrane , Nassiri Mohammadreza , Rajabian-Noghondar Majid , Rahbarian Raheleh , Ramshini Hassan , Jafarian Amirhosein , Ferns Gordon , Avan Amir , Hasanzadeh Malihe
Published: March 2023

Background:

Cervical cancer is one of the most prevalent gynecologic cancers associated
with high morbidity and mortality worldwide. There is mounting evidence indicating an association
between the 9p21 locus genetic variants with susceptibility to various human malignancies. In this current
study, we aimed to evaluate the potential relationship between the rs1333049 genetic variant in
chromosome 9p21 and the risk of cervical carcinogenesis.

Methods:

The possible correlation between rs1333049 polymorphism and susceptibility to cervical
cancer was investigated in 221 patients with or without cancer. DNAs were isolated and genotyped using
a TaqMan-based real-time RT-PCR method.

Results:

The rs1333049 genetic variant was found to be correlated with an elevated risk of cervical neoplasia
using recessive and additive genetic models (p < 0.001).

Conclusion:

Our findings indicated that the CDKN2A/B genetic variant (rs1333049) was significantly
associated with an elevated risk of cancer, suggesting its potential as a novel predictive marker for cervical
carcinogenesis.
Rarer Components of a Rare Disease: Accessory Hemidiaphragm and
Horseshoe Lung with Scimitar Syndrome: Two Case Reports
Authors: Koska Ozgur I. , Alper Hüdaver
Published: March 2023

Introduction:

Scimitar syndrome is a rare developmental anomaly with an incidence of 2/100.000 births. Major components of this disease are partial anomalous
pulmonary venous drainage, pulmonary hypoplasia, systemic arterialization of the right basal lung, and dextroposition of the heart. Horseshoe lung
and accessory hemidiaphragm are two rarer components of this disease.

Case Presentation:

In this paper, horseshoe lung and accessory diaphragm associated with Scimitar syndrome have been reported in two cases.

Conclusion:

In conclusion, being aware of rare manifestations of rare diseases is important to fully describe the pathologic spectrum of the disease. This will
assist in better management and decision-making process.