bluuebunny/crossref_metadata_2025 huggingface dataset:
Monitoring vegetation dynamics using multi-temporal Normalized Difference Vegetation Index (NDVI) and Enhanced Vegetation Index (EVI) images of Tamil Nadu
Authors: Priya M V , Kalpana R , Pazhanivelan S , Kumaraperumal R , Ragunath K P , Vanitha G. , Nihar Ashmitha , Prajesh P J , V Vasumathi
Published: September 2023

Vegetation indices serve as an essential tool in monitoring variations in vegetation. The vegetation indices used often, viz., normalized difference vegetation index (NDVI) and enhanced vegetation index (EVI) were computed from MODIS vegetation index products. The present study aimed to monitor vegetation's seasonal dynamics by using time series NDVI and EVI indices in Tamil Nadu from 2011 to 2021. Two products characterize the global range of vegetation states and processes more effectively. The data sources were processed and the values of NDVI and EVI were extracted using ArcGIS software. There was a significant difference in vegetation intensity and status of vegetation over time, with NDVI having a larger value than EVI, indicating that biomass intensity varies over time in Tamil Nadu. Among the land cover classes, the deciduous forest showed the highest mean values for NDVI (0.83) and EVI (0.38), followed by cropland mean values of NDVI (0.71) and EVI (0.31) and the lowest NDVI (0.68) and EVI (0.29) was recorded in the scrubland. The study demonstrated that vegetation indices extracted from MODIS offered valuable information on vegetation status and condition at a short temporal time period.
Photocatalytic degradation and removal of type II pyrethroid pesticide (lambda-cyhalothrin) residue from wastewater using nanoceria for agricultural runoff application
Authors: Danjuma Sani Mahadi , Abbaraju V.D.N. Kumar , Venugopal N.V.S.
Published: September 2023

Synthetic chemical pesticides' nature, mode of action, and persistence have brought about debates regarding whether the end justifies the means. Lambda-cyhalothrin is an important insecticide for farmers and households, with great accessibility and excellent action against pests and disease-carrying insects. Like other pyrethroid pesticides, Lambda-cyhalothrin targets the nervous system of insects or pests. However, its fate in the environment, especially in water and living systems, has made it crucial to explore methods of treating or degrading its residues in the environment. The present study aimed to develop a suitable method for the photocatalytic degradation and removal of Lambda-cyhalothrin (LCY) from wastewater and agricultural runoff. The nanoceria were used under natural solar irradiation without applying any scavenger chemical or buffer. This was synthesized using a simple co-precipitation method using cerium nitrate hexahydrate as a precursor. The synthesized nanoceria were characterized using X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDS), Fourier Transform Infrared spectroscopy (FTIR) and particle size analysis. The average size of the particle was 27 nm. The photocatalytic degradation was conducted in batches with various pesticide concentrations exposed to different amounts of nanoceria. The initial and final concentrations of the LCY at each level were determined using Shimadzu UV spectroscopy. At optimum conditions, nanoceria was found to degrade and remove more than 63% of the initial pesticide concentration. This method can be suitable for degrading and removing pesticide residue from agricultural runoff (at source) and industrial effluents from synthetic pesticide industries.
Acinetobacter baumannii producing ESBLs and carbapenemases in the Intensive Care Units developing fosfomycin and colistin resistance
Authors: Abdulateef Sura A. , Al-Salmani Mustafa S. , Owaif Hasan A. Aal
Published: September 2023

Acinetobacter baumannii is responsible for causing difficult-to-treat healthcare-associated infections globally, owing to its resistance to antibiotics. The intensive care unit (ICU) settings mediate spread of multidrug resistance (MDR) strains. This research aimed to evaluate non-susceptible colistin and fosfomycin A. baumannii, harboring extended-spectrum beta-lactamases (ESBLs) and carbapenemases in ICU setting. During the period of 2019-2021, this study obtained 200 A. baumanni isolates out of 1410 burns samples from an ICU setting. The antibiotic sensitivity, ESBLs and carbapenemase production were determined using clinical and laboratory standards institute (CLSI) 2020. The colistin (mcr-1 and mcr-2) and fosfomycin (fosA3) resistance genes was amplified. The highest resistance was to ceftazidime (98%), cefepime (86%), tetracycline (84%), levofloxacin (78%) and piperacillin-tazobactam (76%), while the highest sensitivity was to meropenem (63%) and tigecycline (62%). ESBL production was determined in 94% and carbapenemases were observed in 54% of A. baumannii. Four isolates (2%) were found to carry the mcr-1 gene, and three isolates (1.5%) were found to carry the mcr-2 gene. Moreover, the fosA3 was not detected in the isolates. This study showed that MDR A. baumannii was high in ICU settings. The spread of antibiotics considered the last line of defense against infections is a concern that necessitates surveillance and control measures.
Influence of rice husk ash-derived silica nanoparticles on sweetcorn (Zea mays L. sachharata) seed germination
Authors: Kumar S. Pradeep , Yassin M. Mohamed , Marimuthu S. , Kalarani M.K. , Thiyageshwari S. , Meenakshi Guru
Published: September 2023

In agriculture, the utilization of nanomaterials has garnered significant global attention. This research adopts a pioneering approach to investigate the influence of nanosilica on the germination dynamics of sweetcorn seeds. The present study aimed to synthesize and analyze an amorphous nano-silica material using rice husk ash (RHA) and its impact on the germination of sweetcorn seeds (Zea mays L. sachharata). The extracted nano-silica particles dispersed into six rates of suspensions (0, 100, 200, 300, 400 and 500 ppm) were used to study their effects on seed germination. The synthesized amorphous nano-silica was  determined for size, shape, and elemental content. The amorphous nature of the silica sample was confirmed by transmission electron microscopy-selected area electron diffraction (ED) patterns and X-ray diffraction (XRD), whereas siloxane and silanol groups were mainly detected by Fourier-transform infrared (FT-IR) spectroscopy. Image obtained using scanning electron microscopy (SEM) revealed the presence of original nanoparticles alongside secondary microparticles, probably due to agglomeration. Particles in the extracted amorphous silica had an average diameter of 35 nm. Nano-silica powder was amorphous, according to XRD. As per the EDS analysis, the extracted silica sample is 96.87 % pure. The amorphous nano-silica significantly boosted germination metrics such as germination percentage, germination index, vigour index, and mean germination time of sweetcorn. With the addition of 300 ppm nano-silica, the germination percentage increased by 40.1%, the germination index by 96%, and the vigor index by 120% over control seeds. The improvement of seed germination by amorphous nano-silica in sweetcorn implies a potential application of nano-silica in seed germination.
EFFECTS OF FINE AEROSOLS ON THE RESPIRATORY SYSTEM OF INDUSTRIAL WORKERS: A SYSTEMATIC REVIEW
Authors:   FSBEI HE «Kazan State Medical Institute» of the Ministry of Health of Russia, Volkova M.A. , Rakhimzyanov A.R. , Fayzova Yu.M. ,   LLC Clinic-sanatorium «Naberezhnye Chelny»
Published: September 2023

Workers in various industries are at increased risk of respiratory disease as a result of exposure to high levels of airborne particles in the air of the work area during the work shift. Although a clear link has been established between exposure to particulate matter and the development of occupational lung disease, the mechanisms are still poorly understood. A better understanding is required of how exposure to various industrial aerosols encountered in the workplace affects pathophysiological processes in the airways and lungs and leads to various forms of occupational lung disease. Such information is needed to inform safe exposure limits and guidelines for monitoring different types of particulate matter, as well as to develop biomarkers for early disease detection. Results: A total of 5 781 PubMed publications were identified. In total, 283 publications were selected and reviewed with data abstraction. After elimination, 192 publications were considered eligible. 34 publications described the impact of occupational exposure to dust of various compositions, and provided quantitative data on dust and lung function measurements. These studies were used for the review. Conclusion: Our understanding of the mechanism of action of fine and ultrafine aerosols is far from ideal, which emphasizes the importance of further research on both the composition of aerosols in the air of the working area and their effect on the body of industrial workers.
MEDICAL EVACUATION AS CONSEQUENCE OF PROBLEMS IN MARITIME MEDICINE
Authors:   FSBSI «Scientific-Research Institute of Industrial and Marine Medicine of the Federal Medical-Biological Agency», Voronkova S.V. , Levkina Y.V. , Abakumov A.A. ,   Federal Medical Biological Agency, Moscow, Russia
Published: September 2023

The article presents the results of a study carried out by systematization and analysis of data on medical evacuation of ship crews in the marine basins of the Russian Federation in the period 2009‑2019. Structured data on marine basins regarding the causes of evacuation, including those with a fatal outcome during its conduct. The authors come to the conclusion that it is necessary to improve the quality of medical examinations of seafarers, as well as medical support for sea and river vessels, including by determining the requirements for the presence of shipboard medical workers on board and (or) legislative consolidation of alternative types of medical care, taking into account international requirements.
BALANCE OF INTERESTS IN THE FIELD OF OCCUPATIONAL MEDICINE
Authors:   SAHI КO «Kuzbass Regional Hospital named after S.V. Belyaeva», Gavrylyshena K.V. , Semenikhin V.A. ,   FSBEI HE «Kemerovo State Medical University» of the Ministry of Health of Russia, Chasovskih E.V.
Published: September 2023

Kuzbass, being the leading coal-mining region of the Russian Federation, has been a leader for many years in terms of the number of people employed in production with harmful labor factors, as well as the number of occupational diseases detected. A significant number of established occupational diseases gives rise to the problem of emotional and socio-economic interest of employees in connection with their existing diseases with professional activities. Ensuring and protecting the rights and legitimate interests of citizens in the system of relations in the field of healthcare is one of the main tasks of the modern social rule of law state. The aim of the research. To consider the issue of differentiation and balance of interests in the field of occupational medicine. Research methods. Dialectical method of cognition, general scientific, analysis and synthesis. Conclusion. Over the past few years, we have seen an active development of the legal framework in the field of occupational medicine. It is important to structure and regulate legislation in the field of occupational pathology. Сonclusions. The diagnosis of occupational disease or poisoning should be absolutely objective. The development and implementation of new regulatory documents will allow us to maintain such a necessary balance of interests.
THE EFFICACY OF HEALTH PROMOTION PROGRAMMES
Authors:   FSFEI HE «St. Petersburg State University», Grigoreva T.V. , Grigorev N.S. ,   FSFEI HE «St. Petersburg State Pediatric Medical University» of the Ministry of Health of Russian Federation
Published: September 2023

Maintaining and strengthening the health of workers is the most important task for medicine in the modern world. The development of health promotion programmes based on information about their health status seems to be more effective than general health measures. The main purpose of the paper is to evaluate the efficacy of health promotion programmes for employees («Healthy Back») employed in unhealthy working conditions at the car factory in St. Petersburg. The research included an analysis of the results of preventive medical examinations, an analysis of the structure of morbidity of workers in the whole factory and in certain departments (bodywork, assembly, painting, technical service department) in 2019 and 2021. As the activities of the program are mainly aimed at the prevention of neurological pathology. It has been found that in 2021 there was a significant decrease in the frequency of occurrence of neurological pathology in the bodywork, assembly, painting departments. It’s suggested that the use of employee wellness programs has a positive effect on the employees’ health, reduces their morbidity.
FEATURES OF HEART RATE VARIABILITY IN DIABETES MELLITUS IN PATIENTS TRAINED IN THE CONDITIONS OF INDUSTRIAL VIBRATION
Authors:   FSBEI HE «South Ural State Medical University» of the Ministry of Health of Russia, Davydova E.V. , Nuzhdina E.V. , Oleinik V.S.
Published: September 2023

Industrial vibration is one of the most common factors of the labor process. In recent years, similar to the structure of morbidity in the Russian Federation as a whole, an increase in the incidence of type 2 diabetes mellitus has been noted among workers of harmful industries. In this connection, the issues of actual admission to work in contact with the production vibration in the case of diagnosed diabetes mellitus are inevitable. This problem is aggravated by the fact that in chronic hyperglycemia and vibration disease, the pathogenesis processes are unidirectional with respect to changes in the structure of the vascular wall, which in turn is fraught with fatal cardiovascular complications. A study of the health status of patients with diabetes mellitus who had long-term professional contact with industrial vibration was conducted. Using the method of high-resolution rhythmocardiography, peripheral autonomic dysregulations of pacemaker activity of the sinoatrial node of the heart were revealed, causing a change in the wave variability of the heart rate. The degree of dysregulation detected was in direct correlation with the comorbid background corresponding to a single cardiorenal continuum in hyperglycemia. The revealed changes in the heart rate wave variability were regarded as early markers of cardiovascular complications in diabetes mellitus and could be useful in solving the issues of examination of admission to the profession.
WORKING CONDITIONS IN THE PRODUCTION OF LEAD FROM SECONDARY RAW MATERIALS
Authors:   FBSI «Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers» of Rospotrebnadzor, Ivaschenko M.A. , Fedoruk A.A. , Martin S.V.
Published: September 2023

The raw material used in the production of secondary lead determines the working conditions, and, in particular, the chemical and dispersed composition of industrial aerosol — one of the leading risk factors. The purpose of the study was to assess the factors of the production environment in the production of lead from secondary raw materials (based on copper smelter waste). It is shown that the main harmful factors at the workplaces of smelters are industrial aerosol, heavy physical labor, unfavorable microclimate, noise and local vibration, the final assessment of working conditions corresponds to a harmful class of 3 degrees and is characterized by a high (unbearable) occupational health risk. The leading occupational risk factor is an aerosol of complex chemical composition, the main component of which is lead. The formation of the dispersed composition of the aerosol occurs mainly due to fine fractions (PM2.5 and PM1), which indicates its potential toxicity. The obtained materials justify the need for an in-depth study of the dispersed composition of the industrial aerosol of the production under study, the chemical composition of its dispersed fractions in order to subsequently determine the limiting indicators that determine the toxicity of the aerosol and develop preventive measures.
THE CLASSIFICATION TREES METHOD IN ASSESSING THE CONTRIBUTION OF RISK FACTORS TO THE DEVELOPMENT OF CHRONIC PATHOLOGY IN METALLURGICAL ENTERPRISE WORKERS
Authors:   Institute of Industrial Ecology of Ural Branch of the Russian Academy of Sciences, Konstantinova E.D. , Bazarova E.L. ,   Private Healthcare Unit «Tirus»,   FSFEIHE «Ural State MedicalUniversity of the Russian Ministry of Health», Ogorodnikova S.Y.
Published: September 2023

The working conditions of blacksmiths working in the production of titanium alloys are characterized by a high risk of developing an occupationally conditioned pathology of the musculoskeletal system (MSS). The identification of factors that increase and modify the prevalence of chronic pathology, as well as the estimate of their contribution to the prevalence, are relevant and socially significant. The purpose of the study was to assess the contribution of risk factors for the development of chronic pathology of MSS in workers in the production of titanium alloys using the Classification Tree method (CT). Objects and Methods. We used retrospective data from 330 male titanium workers who underwent a routine medical examination in 2020. Data were collected on age, length of service, BMI, and behavioral and occupational hazards (OH). Occupational risk factors at workplaces were: titanium aerosol in the air of the working area, heating microclimate, general and local vibration and the severity of the labor process. The CT method was used to assess the contribution of behavioral and HMF to the development of chronic CMS pathology in blacksmiths. Results. In the structure of chronic pathology among blacksmiths of the studied enterprise, MMS diseases occupied the second place (31,2%). As the experience of blacksmiths increased by 10 years, the number of patients with MSS increased by 8,3% — 18,3%. When the concentration of titanium in the air of the working area is above the MPC (10 mg/m3), a statistically significantly higher prevalence of chronic pathology of the MSS was established in comparison with the group of workers in acceptable working conditions. For workers with overweight and obesity (further — overweight), a tendency to an increase in the prevalence of chronic MSS pathology was found under the influence of general vibration, the severity of the labor process, and smoking. Examples of constructing visual, intuitive decision rules when using CT in a multivariate analysis of the formation of chronic pathology are demonstrated. Conclusions. Significant risk factors for the development of MSS pathology for blacksmiths working in the production of titanium alloys were: experience of more than 11 years, the presence of professional contact with titanium, exposure to general vibration, heavy physical load, overweight, smoking (RR=3,02; 95% CI=2,15‑4,24).
WORKING ENVIRONMENT AND ADAPTIVE RESERVES OF WORKERS BY ORES MINING BODY
Authors:   FBSI «Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers» of Rospotrebnadzor, Kudryashov I.N. , Belomestnova O.V. , Drugova O.G.
Published: September 2023

Prolonged exposure to harmful working conditions can lead to depletion of adaptation mechanisms and the development of work-related diseases, among which diseases of the cardiovascular system (CVD) are of high socio-economic importance. The purpose of the study was to assess the working conditions and the state of the adaptive reserves of the body working in the extraction of ores. The working conditions, lifestyle factors, the adaptive potential of the CCC (AP) in workers of the main professions in underground and above-ground working conditions performing manual and mechanized operations were studied. Working conditions were characterized as harmful 1‑3 degrees. More unfavorable working conditions have been established for underground mining (Class 3.3) compared to surface labor (Class 3.1‑3.2). There is a reliable connection between AP and the nature of work, mechanization of labor, sports. Ground and manual labor, lack of sports activities cause greater stress on the mechanisms, increasing the risk of adaptation disorders.
HEALTH DISORDERS RISK ASSESSMENT OF COAL MINERS, PROBLEMS AND SOLUTIONS
Authors:   FSBSI «Izmerov Research Institute of Occupational Health», Kuzmina L.P. , Golovkova N.P , Varakuta I.S.
Published: September 2023

The coal industry is an essential component of the mining industry. Coal mine workers are exposed by complex and combined harmful and dangerous factors of occupational environment and labor process. Occupational morbidity in coal industry enterprises is higher than all-Russian indicators. The results of epidemiological studies indicate significantly increased standardized relative risk of death from diseases of cardio-vascular system, increased risk of developing malignant neoplasms, respiratory organs especially. Obtained data indicate the need to develop and implement measures to reduce mortality, predict and assess occupational risk, strengthen medical and preventive measures for coal industry workers aimed at increasing the duration of labor longevity.
Năng lượng tái tạo Australia chạm đỉnh mới, bài toán bền vững vẫn còn phải giải tiếp
Authors: Concerné Observateur
Published: September 2023

Trưa ngày 20-9-2023, thị trường điện lực quốc gia Australia đã ghi nhận kỷ lục công suất phát từ các nguồn năng lượng tái tạo, bao gồm điện mặt trời áp mái, các nhà máy phát điện mặt trời quy mô lớn và điện gió, đạt mức 70,6%, cao nhất trong lịch sử.
PHF20 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: September 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5( to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that PHD finger protein 20, encoded by PHF20, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. PHF20 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of PHF20 in primary tumors was correlated with recurrence-free survival. Modulation of PHF20 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Văn hóa kinh doanh và tác động tiêu cực đến môi trường có thể cản trở việc niêm yết cổ phiếu của doanh nghiệp
Authors: Hoàng Nguyễn Minh
Published: September 2023

Một đại gia hàng đầu thế giới trong ngành kinh doanh giết mổ gia súc, chế biến thịt có xuất xứ Brazil là JBS SA đang chịu áp lực lớn từ các nhóm hoạt động môi trường toàn cầu. JBS đang làm hồ sơ niêm yết cổ phiếu tại Sở giao dịch chứng khoán New York (NYSE), với hy vọng sẽ có thể bắt đầu niêm yết vào cuối năm 2023. Tuy vậy, họ bị tố cáo đã gây tác động tiêu cực qua việc phá rừng, thúc đẩy tiêu cực biến đổi khí hậu và hàng loạt các vấn đề liên quan.
Contradictory findings on Taurine and IBD
Authors: Damavandi Pardis Tabaee
Published: September 2023

A short perspective
Collaborative Solutions in Crisis: Documenting Open-Source Initiatives During the COVID-19 Pandemic
Authors: Keogh Colin
Published: September 2023

The COVID-19 pandemic is an unparalleled global crisis that has led to a surge in innovative responses. Central to this innovation landscape was the emergence of open-source projects that offered rapid, collaborative solutions, complementing scientifically led endeavors. This paper undertakes a comprehensive exploration of open-source innovations during the pandemic, chronicling their instigation, impact, and broader implications for research and development (R&D) paradigms. Utilizing a meticulously curated database of open-source COVID-19 innovations, we compared these projects with scientifically led initiatives and derived insights into their respective strengths, challenges, and contributions. Our findings underscore the transformative potential of collaborative research models, emphasizing the synergies between open source and scientific approaches. Furthermore, we delineate the broader implications of these findings for future R&D landscapes, highlighting the pivotal roles of community engagement, adaptability, and interdisciplinary collaboration. This study offers a holistic understanding of innovation dynamics during global crises, serving as a guide for future research endeavors and policy formulations.
GPR158 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: September 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that G protein-coupled receptor 158, encoded by GPR158, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. GPR158 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of GPR158 in primary tumors, however, was not correlated with patient survival outcomes. Modulation of GPR158 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
CP is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: September 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that ceruloplasmin, encoded by CP, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. CP mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of CP in primary tumors was correlated with overall, distant metastasis-free and recurrence-free survival. Modulation of CP expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
GSK3B is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: September 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that glycogen synthase kinase 3 beta, encoded by GSK3B, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. GSK3B mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of GSK3B in primary tumors was correlated with overall, distant metastasis-free and recurrence-free survival. Modulation of GSK3B expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Chuyển động, khoảng lặng và sự xuất hiện của ý thức: tác động qua lại với môi trường
Authors: Nguyen Minh-Hoang
Published: September 2023

Trong một số mới xuất bản của PNAS (Viện hàn lâm khoa học Hoa Kỳ), các nhà nghiên cứu thuộc Florida Atlantic University đã công bố một nghiên cứu công phu, phát hiện thời điểm trỗi dậy của “cái biết có ý thức” (conscious awareness), một ý niệm rất quan trọng đối với quá trình nhận thức và phát triển ý thức của con người. Một ý nghĩa rất sâu sắc của kết quả nghiên cứu này có liên quan tới thế giới tự nhiên, đa dạng sinh thái, và thời gian con người có thể trở nên khỏe mạnh tinh thần khi sống giữa thiên nhiên, tới mức tác giả Weir viết trên Monitor on Psychology [6]: “Thậm chí chỉ âm thanh của tự nhiên cũng có tính chất phục hồi sinh lực”. Như thế, những nỗ lực của con người bảo tồn không gian thiên nhiên, môi sinh và sự đa dạng sinh học, kiểu hình sự sống, cũng chính là bảo tồn nguồn gốc nhận thức, trí khôn, tiếp cận xử lý thông tin, mà những bạn trẻ 3 tháng tuổi trong nghiên cứu đã giúp chúng ta dần hiểu ra. Khi những thông tin từ môi trường được tiếp nhận, xây dựng, lưu trữ, và mở rộng thành các phạm vi ảnh hưởng chủ quan (subjective sphere of influence) trong tâm trí, nó sẽ giúp ta thực hiện các suy nghĩ và hành động có nhận thức rõ ràng, chuẩn xác, và hiệu quả hơn. Đây có lẽ cũng là cách chúng ta học hỏi và xây dựng hệ văn hóa, cũng như tiếp nhận tri thức và tạo ra sự đổi mới sáng tạo trong các khía cạnh của cuộc sống, cụ thể là khoa học công nghệ. Cho nên giá trị thật của không gian thiên nhiên, môi sinh và sự đa dạng sinh học, kiểu hình sự sống rõ ràng không thể nào chỉ tương đương với các món “khoái khẩu” hoặc là doanh số bán vé, thu dịch vụ khách tham quan tại các khu vực bảo tồn được.
MAGOH is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: September 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that mago homolog, exon junction complex subunit, encoded by MAGOH, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. MAGOH mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of MAGOH in primary tumors was correlated with patient recurrence-free survival. Modulation of MAGOH expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Expert Perspectives on the Use, Development, and Integration of Open Source Solutions During Times of Crisis: An Online Survey Study
Authors: Keogh Colin
Published: September 2023

The COVID-19 pandemic highlighted the power of open-source solutions in responding to global health emergencies. However, the integration of such initiatives into established health systems presented a range of challenges. This study seeks to investigate expert perspectives on the use, development, and integration of open-source solutions during emergencies based on the Covid-19 pandemic. Using a comprehensive online survey tool, this study solicited insights from a broad range of stakeholders, thereby gathering crucial perspectives on the challenges, opportunities, and future of open-source initiatives in emergency response.
Pandangan Dasar ekonomi islam
Authors: zahra Camila jiana
Published: September 2023

Ekonomi islam memandang bahwa kelangkaan( scarity) bukanlah problem yang asasi dari ekonomi manusia,dikatakan juga pada saat belajar pengantar manajemen bahwa masalah ekonomi adalah kelangkaan, dimana jumlah permintaan jauh lebih tinggi dibanding penawaran,tetapi dalam islam kelangkaan bukan menjadi masalah bagi manusia,jika membicarakan soal kelangkaan pasti solusinya dengan cara produksi,karena islam tidak memandang kelangkaan sebagai masalah, maka persoalannya bukan produksi,baik apa,bagaimana,dan untuk siapa komoditas nya itu bukan prioritas pembahasan ekonomi islam
Reliability and Validity of an App-assisted Tissue Compliance Meter in measuring Tissue Stiffness on a Phantom Model
Authors: Brandl Andreas , Acikalin Eda , Bartsch Katja , Wilke Jan , Schleip Robert
Published: September 2023

Background. Most methods for soft tissue stiffness assessment require high financial resources, significant technical effort, or extensive therapist training. The PACT Sense device was developed to be used in a wide range of applications and user groups. However, to date, there are no data on its validity and reliability. The aim of this study was to investigate the validity and reliability of the PACT device.Methods. A polyurethane phantom tissue model (PTM) mimicking the mechanical properties of the fascia profunda and the erector spinae muscle was used. Stiffness measurements with PACT were conducted by two independent investigators. For construct validity, correlations were calculated between the known stiffness of the PTM and values obtained with PACT. For concurrent validity, we determined the association between the PACT values and additional measurements with the established MyotonPRO device. To estimate interrater and intrarater (two measurements with an interval of 7 days) reliability, we used the intraclass correlation coefficient (ICC).Results. Correlation analysis (PTM/PACT) revealed very high concurrent validity (r = 0.99; p < .001), construct validity (PACT/MyotonPRO) was 0.87, p < .001. Both, interrater reliability (ICC = 0.85; p = .036) and intrarater reliability were good (ICC = 0.89; p < .001).Conclusions. The PACT provides valid and reliable stiffness measurements in tissue phantoms. Further studies in humans are needed to confirm its psychometric properties under in vivo conditions.
Adverse childhood experience chronicity and timing: a study of UK Black and minority ethnic parents
Authors: Ogundiyun Itunu , Katus Laura
Published: September 2023

Adverse Childhood Experiences (ACEs) are a range of traumatic events, primarily including personal abuse, neglect, and household dysfunction, which frequently are associated with maladaptive consequences into adulthood. As such, ACEs also have the potential to adversely affect an individual’s response to their own children once they become a parent. While members of minority ethnic groups are at a higher risk of experiencing ACEs, research on how this affects parenting outcomes is limited. This study examines ACE exposure in a cohort of N=64 Black and minority ethnic parents in the UK. We found that ACEs were positively associated with parents self-reported harsh parenting, and negatively associated with nurturing parenting. Examining ACE timing, exposure during middle childhood, but not early or late childhood or adolescence, was predictive of both harsh and nurturing parenting. Examining the differential impact of ACE chronicity (i.e., prolonged exposure) and ACE frequency (i.e., number of ACEs), harsh parenting was significantly predicted by ACE chronicity, whereas nurturing parenting was predicted by ACE frequency. Mediation analyses showed a partial mediation of parental education for the link between ACE frequency and harsh and nurturing parenting outcomes. Our results contribute to a growing body of research highlighting the intricate interplay between early life adversity and parenting behaviours within minority ethnic communities. Findings underscore the need for targeted interventions and support systems aimed at breaking the cycle of ACEs, promoting healthier parenting practices, and ultimately fostering improved outcomes for both parents and their children in these communities. Future research should delve deeper into the specific mechanisms through which ACEs influence parenting behaviours and explore culturally sensitive approaches to mitigate their impact on minority ethnic parents.
Reciprocal Relationships between Narcissism and Agentic versus Communal Work Activities across the First Six Years of the Career
Authors: Wille Bart , Heyde Fien , Hofmans Joeri , Vergauwe Jasmine , De Fruyt Filip
Published: September 2023

The vast majority of studies on trait narcissism have adopted a static unidirectional approach, documenting the mainly detrimental effects of this trait on a variety of work outcomes. The current study contributes to this literature by adopting a novel bidirectional perspective, investigating how trait narcissism shapes and is shaped by our experiences at work. Specifically, this study examines how trait narcissism develops during the first six years after the transition from college to work, and how agentic versus communal work demands may either enhance or diminish the development of this trait. Reciprocal relationships between narcissism and subjective and objective work activities are examined in a sample of 1,513 college alumni who were assessed four times across a time period of six years. Both selection (i.e., narcissism shapes work activities) and socialization effects (i.e., narcissism is shaped by work activities) were examined using bivariate latent change score models. Results showed that trait narcissism prior to the college-to-work transition positively predicted the selection of agentic work activities at the beginning of the career, but not future changes in these activities. Importantly, the results regarding socialization effects indicated that engagement in communal activities, particularly those that require relating with others at work (e.g., to help them), diminished trait narcissism over time.
Top-down Attention Does not Modulate Pain Sensitization: Insights from an Experimental Analysis
Authors: Della Porta Delia , Scheirman Eléonore , Legrain Valéry
Published: September 2023

We found no evidence for an effect of high working memory load on the development of secondary hypersensitivity - a proxy of central sensitization.
A reflection on non-epistemic values in environmental psychology research
Authors: Cologna Viktoria
Published: September 2023

In this commentary, I want to raise awareness of the presence of non-epistemic values in environmental psychology, their societal impacts, and how a greater inclusion of non-dominant views can increase the field’s impact and objectivity.
J.J.R. Macleod: Misunderstood, Misinterpreted, and Maligned
Authors: Wright James R.
Published: September 2023

Abstract.

After the discovery of insulin at the University of Toronto in 1921–22, Frederick Banting and Charles Best downplayed the contributions of physiology professor John James Rickard Macleod, the director of the laboratory where the discovery was made. Banting and Best, their allies, and to a lesser extent the university promoted a “fairy tale” version in which the two young investigators made the discovery on their own, creating the so-called “Banting and Best myth.” Over the next 60 years, the myth prevailed and Macleod's reputation became increasingly tarnished, with both Banting and Best actively maligning their former mentor. While the publication of Michael Bliss’ The Discovery of Insulin in 1982 placed Macleod's reputation on the road to recovery, there are still many lingering issues that have been raised, and Macleod remains misunderstood, misinterpreted, and maligned. This paper, using primary and secondary historical sources, addresses topics that have been repetitively raised by Macleod's detractors over the past century.
Problem’S in Crohn’S Disease
Authors: Palmer Walter L.
Published: September 2023

Nearly 40 years have passed since Burrill Crohn of New York City first described a disease he termed terminal ileitis, and later renamed regional enteritis as it became clear that portions of the small bowel other than the terminal ileum were often involved. When the coexistence of disease of the ileum and cecum was recognizd, the designation ileo-colitis became popular. Later, the recognition of granulomatous disease limited to the colon led to the term granulomatous colitis. At the present time there is no clear method, other than the anatomic, of differentiating these various types of non-specific intestinal disease. Basil Morson of St. Mark’s Hospital in London has suggested that the eponym Crohn’s Disease is preferable. The clinical distinction between granulomatous colitis and chronic ulcerative colitis may be very difficult.
The Patterson Laboratories — Newest Addition
Authors: Staley Jayne
Published: September 2023

Named in honor of the late Carl V. S. Patterson, Towanda, Pa., scientist and industrialist, the building houses new laboratories, pharmacy, medical records and nursing administration offices. Long a devoted worker for the Hospital, Mr. Patterson developed an artificial compound suitable for use in making x-ray intensifying screens that brought him national and international recognition.
Effect of different combinations of neuroprotectors on neurological deficit, motor and orientation-research activity, cognitive functions during experimental ischemic stroke
Authors: Karimulin R. F. , Semenenko A. I.
Published: September 2023

Annotation. Today, the maximum efforts of scientists are aimed at preserving the functional capacity and restoring neurons in the ischemic penumbra zone by developing new methods of neuroprotection, one of such approaches could be the combination of different neuroprotectors according to the mechanism of action. The purpose of the study is to study the effect of different combinations of neuroprotectors on neurological deficits, motor and orientation-research activity, and cognitive functions during experimental ischemic stroke. The study was conducted in the modelling of acute stroke according to the ischemic type on non-linear male rats by bilateral ligation of the internal carotid arteries. The four most effective combinations of neuroprotective complexes were selected as neuroprotective complexes (NPC) under investigation: cerebrolysin + mexidol; cerebrolysin + citicoline; cerebrolysin + edaravone; cerebrolysin + choline alfoscerate, which were previously discovered after screening the therapeutic effectiveness of various neuroprotectors and their combinations. Evaluation of the therapeutic effect of NPC was carried out on the 4th and 7th day of therapy. Neurological deficits were assessed using the McGraw Stroke Index. Locomotor and orientation-research activity was determined in the “open field” test. Cognitive functions were investigated in the extrapolation release test. The study of the cerebroprotective properties of four different combinations of neuroprotectors on an experimental model of an ischemic impression of the brain based on indicators of neurological deficit, locomotor and orientation-research activity, and cognitive functions made it possible to identify the most effective combinations and arrange them in order of decreasing effectiveness: NPC № 2 ≥ NPC №1 > NPC №4 ≥ NPC №3.
The state of health and adaptation of children with the identified abnormally attached chords of the left ventricle
Authors: Kuleshov O. V. , Kurets O. O. , Laiko L. I. , Medrazhevska Y. A. , Oliynyk V. S.
Published: September 2023

Annotation. In recent years, there has been a growing focus among medical professionals and researchers on examining and understanding the various manifestations of connective tissue dysplasia syndrome (CTD). A common anatomical defect of the heart is the presence of abnormally attached chords (AAC) within its chambers. The aim of the work is to conduct a clinical examination of children with AAC in the left ventricle to identify symptoms that will allow predicting of possible diseases and preventing their occurrence. A clinical examination of 92 children aged 13 to 17 was carried out. The main group consisted of 62 children with confirmed additional AAC, identified through Doppler echocardiography. The AAC had a transverse orientation in the left ventricle of the heart. The control group consisted of 30 practically healthy children. The examination included a thorough collection of medical history (compulsory communication with parents) and the assessment of autonomic regulation (AR) using the tilt table test (TTT). To assess the research findings, we utilized both absolute and relative statistical indicators using the Microsoft Excel program on an IBM PC/AT computer. Differences between the results of the two samples, which followed a normal distribution, were evaluated using the parametric Student's t-test. Analysis of the obtained anamnesis data showed that mothers of children with AAC had various extragenital pathologies before and during pregnancy. The reported data primarily consisted of information regarding the presence of cardiovascular diseases, as well as conditions such as pyelonephritis, chronic gastritis, and allergic diseases. Additionally, multiple types of hereditary connective tissue disorders were confirmed among the family members of the children being examined. The antenatal anamnesis was mainly aggravated by early toxicosis of pregnancy and the occurrence of intrauterine hypoxia. Among the most common complaints in children with AAC were: increased fatigue, weakness, reduced work capacity, lack of endurance during physical exertion, periodic cardiac pain, increased heartbeat, headache, dizziness, and intermittent abdominal pain. In the examined individuals, the excessive AR was mainly determined in the form of a hyperadrenergic variant. Insufficient involvement of the sympathoadrenal system was manifested mostly in the form of an asympaticotonic variant. Mixed variants (sympathicoasthenic and asthenosympathetic) occurred rarely. So, the state of vegetative homeostasis in this group of children requires more detailed study to further correct and prevent the occurrence of cardiovascular diseases.
Levels of leptin and adiponectin in patients with SLE, relationship with features of the course of the disease
Authors: Shkilna O. O.
Published: September 2023

Annotation. The aim of the work was to establish possible differences between the levels of leptin and adiponectin in patients with systemic lupus erythematosus (SLE) and practically healthy people, as well as to identify probable patterns of changes in the levels of adipokines depending on the features of the course of the disease. We examined 79 patients with SLE and 30 practically healthy individuals of the control group. The content of leptin and adiponectin in blood serum was determined by the immunoenzymatic method according to the instructions of the manufacturer “Leptin ELISA (CAN-L-4260)” (DBC, Canada) and “Adiponectin ELISA Kit” (DBC, Canada). The SELENA-SLEDAI index was used to assess activity. Metabolic syndrome was established according to the IDF (2005) criteria. Statistical processing of the obtained results was carried out on a personal computer using the methods of parametric and non-parametric statistics using the program Statistica 12.5 (StatSoft Inc., USA) and Microsoft Excel 2016. During the study, it was found that the level of leptin was reliably 45.1% higher in patients with SLE than in the control group, which correlated with the age of the patients, the duration of the disease, the closest relationship was found with the activity of the inflammatory process according to the SLEDAI index (r=0.78) and ESR (r=0.54). SLE patients with metabolic syndrome had 60.5% higher average leptin values. According to the level of adiponectin, it is 17.8% lower in patients with SLE than in practically healthy people. With increasing age and duration of the disease, a significant decrease in the level of adiponectin was found in patients with SLE. All this determines the prospects for further research of these indicators and establishing their role in the progression of SLE.