bluuebunny/crossref_metadata_2025 huggingface dataset:
Proposta de diretriz para o cuidado farmacêutico nas urticárias
Authors: Gabriela Maicá Rodrigues  , Rafael Santos Santana  , Ana Paula de Oliveira Barbosa
Published: November 2023

Introdução: Frente a necessidade de mudança na atuação do farmacêutico, lidando de forma direta com os pacientes e suas necessidades, onde efetua o manejo dos problemas de saúde autolimitados, observou-se a necessidade de um direcionamento da prática clínica no manejo destes problemas como a Urticária, doença dermatológica que acomete cerca de 1% da população, com isso foi elaborado esse documento, baseado em evidências, orientando terapias farmacológicas ou não farmacológicas e sinais de alerta para encaminhamento. Objetivos: Com o objetivo de guiar o farmacêutico na atuação clínica foi elaborada a diretriz clínica para o cuidado farmacêutico nas urticárias. Material e Método: Para elaboração da diretriz foi utilizado o método ADAPTE, composto de 3 fases, configuração, adaptação e finalização. A pesquisa foi realizada através do uso dos descritores Decs/Mesh (urticária) e operadores booleanos AND guideline OR management, em sites de síntese de evidências sobre o tema, (DYNAMED, BMJ, BEST PRATICE, MEDSCAPE, UPTODATE), com filtros de MetaAnalysis, Systematic Review. Os artigos de evidência foram selecionados pela classificação GRADE. Resultados: A urticária é uma doença dermatológica que possui grande influência na qualidade de vida dos indivíduos já que seus sintomas, pruridos e eritemas, interferem nas atividades rotineiras, causando incômodos, estresse e desconforto frente à sociedade. Essa doença se classifica em aguda ou crônica, porém em ambos os casos a terapia medicamentosa se baseia em anti-histamínicos H1 de segunda geração. A terapia medicamentosa pode ser feita em dose padrão para ambos os casos e pode ser feita elevação de dose, em até 4 vezes a dose mínima, para casos crônicos (Quadro 1). As terapias não medicamentosas variam de acordo com o grau de evidência. Discussão e Conclusões: Com a pesquisa sobre evidências que embasassem a melhor alternativa de tratamentos farmacológicos ou não para o controle das urticárias elaborou-se um guia referenciado para o manejo clínico das urticárias pelo farmacêutico, com indicação dos medicamentos de maior evidência assim como a alternativa não medicamentosa de melhor evidência.
Unitarização de medicamentos em um hospital de grande porte do Distrito Federal: uma análise farmacoeconômica
Authors: Isabela Beatriz Cosma de Souza  , Ana Vitória Neves de Oliveira  , Camila Alves Areda  , Rinaldo Eduardo Machado de Oliveira  , Antônio Leonardo de Freitas Garcia
Published: November 2023

Introdução: A unitarização de doses de medicamentos é o processo realizado sob responsabilidade de um farmacêutico ou sob sua orientação, que visa a subdivisão de forma farmacêutica ou transformação destas em doses unitárias estáveis, préestabelecidas, preservando sua qualidade e rastreabilidade¹. Objetivos: Objetivou-se analisar a unitarização de medicamentos em um hospital de grande porte do Distrito Federal na perspectiva farmacoeconômica. Material e Método: Trata-se de um estudo observacional, retrospectivo e descritivo. Foi realizada uma pesquisa bibliográfica e levantamento de dados do laboratório de farmacotécnica local, entre janeiro de 2020 e agosto de 2022. Os processos e etapas percorridos pelos medicamentos desde a entrada no hospital até a distribuição, foram averiguados e registrados por meio de um fluxograma criado com a ferramenta BizAgi Process Modeler. Resultados: Verificou-se que a implementação da unitarização foi simples e de baixo custo para o hospital. Também houve uma redução de custos no caso da alteplase, além de redução no desperdício de soro fisiológico, e demais medicamentos, bem como controle e diminuição do desabastecimento quando avaliado a metilprednisolona. Constatou-se que os registros dos processos de unitarização e dispensação adotados ainda não são capazes de garantir toda a rastreabilidade dos medicamentos. Entretanto, a unitarização é financeiramente viável, podendo chegar a uma economia de até US$36,673.00 com apenas um medicamento, no período avaliado. Discussão e Conclusões: Uma limitação importante foi a ausência do registro sistemático de dados sobre os processos e resultados da unitarização, em especial das informações relacionadas à distribuição, dispensação e descarte de medicamentos, que impossibilitaram a realização de cálculos com maior acurácia acerca do valor efetivamente economizado aos cofres públicos. Entretanto, apesar desta limitação, o impacto farmacoeconômico mostrou-se positivo e a unitarização conduziu aos resultados superiores à utilização dos medicamentos em suas apresentações comerciais por reduzir eventuais desperdícios e melhoria na segurança do paciente, ampliação do acesso, bem como, redução da possibilidade de desabastecimento. Este resultado vai de encontro a outros estudos disponíveis na literatura sobre o tema.
«Vaki og viljesterk»: Funksjonshemming som forestilling, identitet, politikkfelt og sosial arena ca. 1925–1960 belyst gjennom Sørlandske krets av Norges Vanførelag1
Authors: Hagen Thomas V. H.
Published: November 2023

For decades prior to the foundation of the Norwegian Association of the Disabled in 1931, a wide range of predominantly local institutions and associations dedicated to the improvement of education, healthcare and living conditions for the disabled had arisen. One such was the Association of the Disabled in Southern Norway, which quickly after its foundation in the mid-1920s gained a foothold throughout the counties Agder and Telemark. This article explores three main areas. First, who were the members this association, and which issues were they concerned with? Did it develop into an association of the disabled as intended, or for those who wanted to help? Second, which views of disability manifested themselves within the disability movement until the 1960s, and how should these be understood? Six facets are identified: philanthropic charity, economic self-reliance, compassion, preaching, solidarity practices, and interest politics. Although these concepts suggest a historicization, the article argues that the way in which these different ideas co-exist is a characteristic feature. Third, the article discusses the extent to which this case study may bring new insights into the ways society at large produces and grapples with concepts of variations of the physical body.
Why do we Modify Ovarian Stimulation Protocols when Repeating a Cycle?” Is it a Scientific Issue, An act of Faith, or a Lack of Trust?
Authors: G Barrenetxea
Published: November 2023

Ovarian Stimulation (OS) is a cornerstone and indispensable step in reproductive medicine. The aim of OS is to induce the growth and maturation of multiple follicles to collect an adequate number of oocytes. The availability of a sufficient number of mature oocytes suitable for in vitro fertilization (IVF) significantly enhances the likelihood of successful fertilization, the development of high-quality euploid embryos, and ultimately, the achievement of a successful pregnancy. Frequently, it becomes necessary to repeat an ovarian stimulation procedure in a patient. In some instances, when faced with a poor ovarian response, the strategy of oocyte accumulation is employed to increase the chances of having a euploid blastocyst available for transfer. Moreover, even among good responders, there are occasions where it becomes necessary to repeat a cycle due to a prior unsuccessful attempt. The present study shows that there is a great variability in ovarian response in successive ovarian stimulation procedures, even administering the same protocol, both in terms of doses and medications. Thus, repeating an ovarian stimulation procedure does not necessarily entail the need to modify the stimulation protocol. There is variability in ovarian response even when the same gonadotropins are administered, as shown in the present study. Hence, in consecutive stimulations, variations in the response are physiological, even though the same protocol and medication are employed. Selecting one protocol over another should prioritize the comfort and convenience of the patient rather than a hypothetical improved response with different medications.
A Case of Multinodular Goiter Treated with Iodum 200 C
Authors: GG Tejasvikas
Published: November 2023

Hyperthyroidism is a pathological disorder in which excess thyroid hormones are secreted by the thyroid gland. Hyperthyroidism increases with age and is more frequent in women. Hyperthyroidism develops in most of the cases of Multinodular Goiter after frequent intake of iodine. Multinodular Goiter (MNG) is the most common disorder of the thyroid gland result of the genetic heterogeneity of follicular cells and apparent acquisition of new inheritable cellular qualities. It is most often detected as a simple mass in the neck but sometimes an enlarging gland produces pressure symptoms. This article describes a case of a 39-year-old female patient who presented with swelling in neck associated with pain in left eye and blurred vision since 2 years. The case was diagnosed as Multinodular Goiter and treated in the OPD of our hospital. Thorough case taking was done and the totality of symptoms was constructed. Based on the totality, Iodum 200 C / 5 doses once in 3 days were prescribed for 2 weeks. The case got remarkably improved within a period of 4 months with the thyroid hormones ranging within normal limits. Thus it is evident that Multinodular Goiter with hyperthyroidism can be treated efficiently with well selected specific homoeopathic medicines.
Can ESG Performance Moderate The Effect of Tax Avoidance on Corporate Risk?
Authors: Carolina Verani , Gunawan Yuliana , Tedya Ranesa
Published: November 2023

Very few companies in Indonesia implement environmental, social, and governance (ESG), but nowadays investors are interested in investing in companies that have good ESG profiles. This study aims to find the moderating effect of ESG performance on the effect of tax avoidance on corporate risk. The ESG score was obtained through the Thomson Reuters Eikon (Refinitiv), while tax avoidance was measured using the Effective Tax Rate and Cash Effective Tax Rate. This study used a sample of companies with ESG scores in the 2012-2021 period. The data was analyzed using panel data moderation regression with eviews 12. The best regression model obtained is the Fixed Effect Model (FEM). The results showed that ESG performance can moderate the effect of tax avoidance on corporate risk.Keywords: Environmental, Social, and Governance (ESG), tax avoidance, corporate risk.
The Role of Intellectual Capital in the Relationship between Good Corporate Governance, Financial Performance and Financial Distress
Authors: Jati Ahmad Waluya , Kholmi Masiyah , Jannah Wardatul
Published: November 2023

This study examines the effect of good corporate governance and financial performance on financial distress, with intellectual capital as a moderating variable. Good Corporate Governance, Financial Performance and Intellectual Capital are important tools that assure investors of the health of a business, thereby attracting interest to invest in companies that affect the capital to be obtained so as to increase company profits. Companies that are continuously able to make profits will avoid financial distress. This is due to the good management of the company, thereby increasing the value of the company. The sample in this study consisted of 150 observations from 75 manufacturing sector companies listed on the Indonesia Stock Exchange from 2020-2021. Manufacturing companies are the leading industry with the highest GDP contribution compared to other sectors. The Research result are derived from the multiple regression and MRA methods used in this study.  Research results show that good corporate governance and financial performance have a positive effect on financial distress. Meanwhile, intellectual capital can strengthen the link between good corporate governance and financial distress. This research can support signal theory which can provide a good framework for understanding the impact of good corporate governance and financial performance on financial distress. This theory explains that companies, as senders of information (information owner), want to make the information relevant to the use of the information by the recipients or users most concerned.
Bibliometric Waqf Management in Indonesia
Authors: Heppy Purbasari  , Bawono Andy Dwi Bayu , Rangga Handika  , Triyono
Published: November 2023

A significant quantity of abandoned waqf lands in Indonesia is evidence that the optimal management of waqf has yet to be achieved. The primary objective of this study is to identify and analyze the existing research lacunae in prior studies, hence facilitating the delineation of future research directions. The employed research methodology utilizes a quantitative approach, wherein publications are quantified using the publish or perish tool and analyzed using the Vosviewer software afterward. This study employs the terms "waqf management" OR "waqf management" AND Indonesia to search for papers inside the Scopus database, focusing on the research period from 2015 to 2022. The study yielded a total of 14 papers about the management of waqf. These articles were categorized into four distinct research areas, namely: (1) the enhancement of productive waqf, (2) the administration of the waqf system, (3) the legal aspects of waqf, and (4) crowdfunding through Sukuk. Based on the four themes above, it is evident that the advancement of productive waqf has been implemented throughout many waqf institutions in Indonesia, yielding favorable outcomes in enhancing the socio-economic conditions of impoverished individuals.
4% Articaine Buccal Infiltration Versus 2% Lignocaine Inferior Alveolar Nerve Block for Pulpal Anaesthesia in Mandibular First Molars
Authors: Ali Md. Ashraf , Akter Khaleda , Molla Md. Tarik Immam Hossain , Kabir Rezaul
Published: November 2023

The aim of the quasi-experimental study was to assess and compare anaesthetic efficiency of 4% articaine buccal infiltration (BI) and 2% lignocaine inferior alveolar block (IANB) for pulpal anaesthesia in mandibular first molars. Thirty-nine participants with healthy 1st molar teeth on both sides of the mandible who came for root canal treatment of adjacent teeth were recruited for the trial. All participants received 2% lignocaine IANB on 1st visit and 4% articaine BI on 2nd visit and the appointment was given at least 1 week apart. Pulpal anaesthesia onset and duration were checked by an electric pulp tester. The result showed that 4% of articaine BI secured 53.8% successful pulpal anaesthesia in mandibular first molar teeth while 2% of lignocaine IANB did 61.5%, and this difference was not statistically significant. The onset time of pulpal anaesthesia showed no significant difference between these two methods. But, the duration of pulpal anaesthesia was significantly shorter in articaine BI than in lignocaine IANB. It can be concluded that 4% articaine BI is a safe and effective method for pulpal anaesthesia in mandibular first molar teeth. But it should be used considering its shorter duration.
SCN5A mutation is associated with a higher Shanghai Score in patients with type 1 Brugada ECG pattern
Authors: Tonelli Laura , Balla Cristina , Farnè Marianna , Margutti Alice , Maniscalchi Eugenia Tiziana , De Feo Gaetano , Di Domenico Assunta , De Raffele Martina , Percesepe Antonio , Uliana Vera , Barili Valeria , Serra Walter , Sassone Biagio , Virzì Santo , De Maria Elia , Parmeggiani Giulia , Assenza Gabriele Egidy , Biagini Elena , Parisi Vanda , Biffi Mauro , Carinci Valeria , Perugini Enrica , Imbrici Paola , Ferlini Alessandra , Bertini Matteo , Selvatici Rita , Gualandi Francesca
Published: November 2023

Aims

Brugada syndrome (BrS) is an inherited arrhythmic disease characterized by a coved ST-segment elevation in the right precordial electrocardiogram leads (type 1 ECG pattern) and is associated with a risk of malignant ventricular arrhythmias and sudden cardiac death. In order to assess the predictive value of the Shanghai Score System for the presence of a SCN5A mutation in clinical practice, we studied a cohort of 125 patients with spontaneous or fever/drug-induced BrS type 1 ECG pattern, variably associated with symptoms and a positive family history.

Methods

The Shanghai Score System items were collected for each patient and PR and QRS complex intervals were measured. Patients were genotyped through a next-generation sequencing (NGS) custom panel for the presence of SCN5A mutations and the common SCN5A polymorphism (H558R).

Results

The total Shanghai Score was higher in SCN5A+ patients than in SCN5A– patients. The 81% of SCN5A+ patients and the 100% of patients with a SCN5A truncating variant exhibit a spontaneous type 1 ECG pattern. A significant increase in PR (P = 0.006) and QRS (P = 0.02) was detected in the SCN5A+ group. The presence of the common H558R polymorphism did not significantly correlate with any of the items of the Shanghai Score, nor with the total score of the system.

Conclusion

Data from our study suggest the usefulness of Shanghai Score collection in clinical practice in order to maximize genetic test appropriateness. Our data further highlight SCN5A mutations as a cause of conduction impairment in BrS patients.
Timing, positioning and ancillary therapies: the triad for successful Impella RP
Authors: Bertolin Stephanie , Maj Giulia , Secco Gioel Gabrio , Pullara Alberto , Gherli Riccardo , Cardinale Astrid , D’Ettore Nicoletta , Cavozza Corrado , Audo Andrea , Pappalardo Federico
Published: November 2023

Clear clinical guidelines for the assessment and treatment of right ventricular failure (RVF) remain an unmet need. Although high complexity patients are common in this setting, the ideal management remains uncertain, resulting in high mortality rates despite presumably optimal medical therapy. Timely treatment with Impella RP may offer benefits by supplying circulatory support during the acute RVF phase and providing the time and unloading necessary for native right heart recovery. As such, mastering the technicalities and ancillary therapies is crucial to best utilize this salvage opportunity, particularly in these high complexity patients. Here, we report three different clinical scenarios of medically refractory RVF supported with Impella RP to provide examples and discuss the contribution of mechanical RV support to patient outcomes.
Nonpharmacological interventions for ‘no-option’ refractory angina patients
Authors: Paz Yoav , Levy Yair , Grosman-Rimon Liza , Shinfeld Amihay
Published: November 2023

Refractory angina pectoris (RAP) defined as chronic anginal chest pain because of coronary artery disease (CAD) is a major problem. The increase in the number of patients with RAP in recent years is because of the increasing aging population and improved survival rates among patients with CAD. Management of patients with RAP is often extremely challenging. In this review, we present several interventional approaches for RAP, including device therapies, lifestyle intervention, and cell therapies. Some of these treatments are currently used in the management of RAP, whereas other treatments are under investigation.
Improving Business Sustainability by Connecting Business Continuity Management and Risk Management
Authors: Mošková Erika , Buganová Katarína
Published: November 2023

Business continuity management is a tool that provides a structured framework for building business sustainability with the ability to respond effectively, protecting the interests of key stakeholders as well as other key activities that create value for the business. It is the disruption of the enterprise’s key activities that can cause problems that enterprises may not be able to handle without proper help and can lead to bankruptcy. The action of various factors from the external as well as the internal environment can change the overall development of the enterprise depending on its reaction to the given change, at the same time, in connection with its initial readiness, ensured prevention of the enterprise. Maintaining business continuity is closely related to ensuring the smoothness of business processes. Business continuity management is a management process that identifies potential threats and their impact on the enterprise’s business operations. Therefore, the article aims to highlight the benefits of the implementation of business continuity management in enterprises, which would ensure the course and smoothness of business operations. At the same time, in combination with risk management, it is possible to reach a better understanding of the enterprise and its activities that ensure the running of the enterprise. The importance of business continuity management and risk management lies primarily in the enterprise’s readiness to face unexpected situations, while the appropriate selection of methods, techniques, and procedures can help to activate and create a sustainable enterprise system. By implementing business continuity management and risk management, it would be possible to achieve an improvement in the enterprise’s response to adverse situations but also in the overall course of the executed processes concerning the operation of the enterprise. Interruption of business operations can be caused by various factors, which have an impact mainly on the ability of the business to function even in difficult, unpredictable situations. Therefore, in this context, the main emphasis is placed on prevention, preparedness, and the ability of the enterprise to respond promptly to changes in the environment and the ability to transform its activities in its entire structure.
Vad mammor beskriver att de gör för att stödja sina barn i årskurs 1, med ett särskilt fokus på läs- och skrivutveckling
Authors: Axelsson Annika
Published: November 2023

The purpose of the study is to contribute with knowledge about what mothers describe doing to support their children in grade 1. The research questions are as follows: What do the mothers do to support their children’s education on a general level? What do the mothers do to specifically support their children’s reading and writing development? Eleven parents (all mothers) participated. Interviews were analysed thematically, whereby six themes addressing their support were identified: 1) Talk with children about school; 2) Handle school-related problems; 3) Have a positive attitude towards school; 4) Guide children’s reading and writing; 5) Coach specific training; and 6) Collaborate with school staff about children’s reading homework. The bioecological model for human development constitutes a theoretical frame and an understanding of what influences children’s development, for example, parents’ support to children’s reading and writing development. It provided useful concepts (e.g., microsystem, proximal processes, mesosystem, and chronosystem) for a discussion of the themes. The study is relevant for prospective and professional teachers in early grades, special needs teachers, other school staff, principals, policymakers, and parents.
Factors associated with patients bypassing primary healthcare centers in Riyadh, Saudi Arabia
Authors: Shalhoub Fahad , Alharbi Majed , Alshammari Shahad , Rakhis Raghad , Saif Asayel , Alateeq Fahad
Published: November 2023

Objective:
This study aimed to investigate the reasons for bypassing primary healthcare centers in Riyadh city, Saudi Arabia.
Methodology:
This study used a descriptive, questionnaire-based, and cross-sectional design with a non-probability convenience sampling. The data collection tool was a self-administered questionnaire, which included questions on sociodemographic data, satisfaction with services, knowledge of services, and reasons for bypassing primary healthcare centers.
Results:
The study included 588 participants, of which 264 (44.9%) were males, and 64.1% were aged between 18 and 24 years. Majority of the participants visited a PHC center at least once (94.9%), but also experienced a failed treatment (42.8%) or a lack of medications or diagnostic services in PHC (61.1%). The most common reason for bypassing PHC was the unavailability of diagnostic measures (38%), followed by the need for more experienced staff (33%). The study also found significant associations between gender, employment status, age and the reasons for bypassing PHC.
Conclusion:
Although there is considerable reported utilization of PHC center services, there was a high rate of bypassing PHC facilities for various reasons. The main factors influencing bypassing behavior were the availability of diagnostic measures, drugs, and experienced staff. Therefore, improving the quality and accessibility of PHC services is essential to reduce the bypassing rate and enhance the utilization of PHC in the study area.
A case of acute aortic dissection in emergency department: lessons learned
Authors: Zaabi Ibraheem , Jaber Mohamed , AlSuwaidi Ahmed
Published: November 2023

Background: Early diagnosis of Acute Aortic Dissection (AAD) can be a challenge for emergency physicians given its unspecific and variable presentation. For this reason, it is frequently referred to as \"the great imitator,\" as it can mimic so many other conditions, including acute coronary syndrome and stroke.
Case Presentation: We report a middle-aged male who presented to the Emergency Department (ED) with complaints of dizziness. His vitals showed differences in blood pressure (BP) between both arms and an absent pulse in the right arm. a computerized tomographic (CT) angiography of the aorta, which showed a Stanford type A aortic dissection. The patient was in stable condition until he was transferred to another health care facility for further care and intervention. AAD is a challenging diagnosis to make in the ED and has a high mortality rate, especially if there is a delay in diagnosis and definitive management.
Conclusion: So far, there are no blood tests available that accurately rule in or rule out AAD. While bedside transthoracic echocardiography can be used as an adjunct test in unstable patients, computerized tomographic (CT) angiography remains a pragmatic reference standard for the diagnosis of AAD.
HUBUNGAN ANTARA GAYA HUMOR DENGAN PERILAKU AGRESI PADA REMAJA PENGGEMAR K-POP
Authors: Tanadi Anastasia Chrisella , Wijaya Erik
Published: November 2023

Tujuan dari penelitian ini untuk menguji hubungan antara gaya humor dengan perilaku agresi pada penggemar K-Pop di Indonesia. Setiap individu memiliki gaya humor dan persepsi terhadap humor yang berbeda. Gaya humor adalah salah satu kepribadian yang menetap pada individu dan tiap individu memiliki selera humor yang berbeda. Dalam dunia K-Pop, penggemar menggunakan humor sebagai salah satu sarana berkomunikasi dengan antar penggemar. Akibatnya, hubungan antar penggemar dapat semakin meningkat. Namun, agresi (seperti fan war) dapat muncul jika antar penggemar memiliki persepsi yang berbeda dan tidak paham dengan humor tersebut. Agresi adalah perilaku menyakiti seseorang secara fisik dan/atau psikologis. Jika perilaku agresi terjadi akan memberikan dampak buruk bagi korban maupun pelaku. Jenis penelitian yang dilakukan adalah metode penelitian kuantitatif cross-sectional dan pengambilan data menggunakan convenience sampling dan snowball sampling. Pengumpulan data dilakukan pada 13-25 Februari 2022 dan menghasilkan 416 responden, yang terdiri dari 404 perempuan dan 12 laki-laki. Alat ukur yang digunakan adalah Humor Style Questionnaire (HSQ) oleh Martin et al. (2003) dan Buss and Perry Aggression Questionnaire oleh Buss dan Perry (1992). Analisis data partisipan menggunakan SPSS dengan teknik korelasi Spearman antara affiliative humor, self-enhancing humor, aggressive humor, self-defeating humor, dengan perilaku agresi. Hasilnya, penggunaan gaya humor affiliative dapat menurunkan perilaku agresi (p = 0.000 <0.05), sedangkan penggunaan self-enhancing humor (p = 0.000 < 0.05), aggressive humor (p = 0.000 < 0.05), dan self-defeating humor (p = 0.000 < 0.05) dapat meningkatkan perilaku agresi.
APAKAH PSYCHOLOGICAL CAPITAL DAN WORK ENGAGEMENT MEMBENTUK JOB PERFORMANCE KARYAWAN DI ERA SOCIETY 5.0?
Authors: Gregorio Keanen , Jap Tji Beng , Tiatri Sri
Published: November 2023

Globalisasi menjadikan tenaga kerja sebagai sebuah komoditas, artinya semua aspek dalam tenaga kerja, baik kemampuan, kognitif, otak, dan otot dapat diperjualbelikan. Pengalaman konsumen menjadi fokus yang utama pada era Society 5.0. Oleh sebab itu, seorang karyawan perlu meningkatkan kinerja pekerjaannya agar dapat memberikan pengalaman konsumen yang terbaik. Demi mempersiapkan karyawan dalam menghadapi era Society 5.0, diperlukan suatu sumber daya pribadi yang baik. Salah satu sumber daya pribadi tersebut adalah psychological capital atau modal psikologis. Tujuan penelitian ini adalah mengetahui bagaimana modal psikologis dan keterikatan kerja membentuk kinerja pekerjaan karyawan di Era Society 5.0. Dengan mengetahui bagaimana modal psikologis dan kinerja pekerjaan dalam pembentukan kinerja pekerjaan, perusahaan dapat menciptakan program-program yang dapat meningkatkan modal psikologis dan keterikatan kerja sehingga kinerja pekerjaan karyawan dapat ditingkatkan. Metode pendekatan kuantitatif digunakan dalam penelitian untuk mengukur variabel modal psikologis, kinerja pekerjaan, dan keterikatan kerja. Ketiga variabel tersebut diukur melalui kuesioner daring yang dibagikan oleh Peneliti. Penelitian ini dilakukan pada karyawan sales di perusahaan yang bersifat for-profit sehingga dapat memberikan perspektif yang berbeda mengenai variabel modal psikologis, kinerja pekerjaan, dan keterikatan kerja pada karyawan. Dalam penelitian ini juga ditambahkan Key Performance Indicator (KPI) agar kinerja pekerjaan yang diukur menjadi lebih objektif. Hasil penelitian menunjukkan bahwa adanya hubungan positif antara modal psikologis dan keterikatan kerja, begitu juga antara keterikatan kerja dan kinerja pekerjaan.
La representación deportiva y su papel en la seguridad multidimensional desde la diplomacia de defensa
Authors: Cortes-Fernández Santiago
Published: November 2023

La seguridad multidimensional de la nación debe considerar todos los aspectos con los cuales puede posicionarse dentro del sistema internacional y a la valoración de las capacidades militares convencionales (hardpower) se le debería aportar la valoración de las capacidades culturales, los valores políticos y la política exterior. En el marco de la expresión de las capacidades culturales, el deporte es un factor que proyecta la capacidad estratégica de las naciones e incluso según lo expresan el Comité Olímpico Internacional «la práctica del deporte es un derecho humano» y el Comité Paralímpico Internacional «la accesibilidad es un derecho humano básico y un pilar fundamental de justicia social»; debe considerarse entonces, que el posicionamiento de las naciones en las competiciones deportivas, refuerza el concepto de legitimidad, agrega valor en términos de la identidad nacional y mejora la ubicación del país en el marco del “ranking” de las naciones, dentro del Sistema Internacional.
Feasibility study on formulation of cutting fluid from waste palm oil
Authors: Yoosuf Shabna , Maneesh T. , Sasidharan Baiju , Rani S. , Ajmal N. , Mohanan Visakh
Published: November 2023

From an industrial, environmental, and scientific standpoint, the creation of renewable and sustainable products to replace fossil fuels is an important concern in this decade. Due to the growing use of different lubricant types, the majority of which are mineral-based, there is an unavoidable flow of mineral-based lubricants into the environment. Another issue is using cooking oil that pollutes the environment when discarded. Both of these issues can be resolved by creating bio-based lubricants from discarded cooking oil. This article discusses formulating a green cutting fluid made from used cooking oil. This enables the use of waste oil as a cutting fluid while retaining its tribological and environmental characteristics. In order to compete in the market, biodegradable cutting fluid might gain from decreased costs for used natural oils. The many components and trends that make up this topic are briefly covered in this article, along with waste cooking oils’ potential application as a bio-based lubricant.
Production, Purification, Characterization and Anti biofilm activity of natural antibiotic by Actinokineospora cibodasensis from marine water
Authors: Sreelakshmi K.S. , Usha R.
Published: November 2023

Health sector faces a distress globally because of the scarcity of newer antibiotics against drug resistant pathogens. Innovations in developing new antibiotics is the solution to combat the drug resistant pathogens. This alarming situation requires advanced, potential and effective antibiotics. Secondary metabolite products from microbes remain as the main origin for many of the antibiotics in the market today and are also found to be promising till date. Out of the microbes, the major share of antibiotic production is reported by Actinomycetes, which are Gram positive, anaerobic, filamentous bacteria. They are currently being exploited through new approaches to improve the efficiency of commercially valuable antibiotics. Since natural environment stands a potential source of innovative and novel antimicrobials, this investigation was performed to test the potential of selected marine actinomycetes. Of the screened ones, Actinokineospora is potential enough to cease the growth of biofilm formation. This strain was identified by molecular characterization as Actinokineospora cibodasensis. It was selected to extract secondary metabolites by submerged fermentation and made to undergo further purification and structural analyses for the search of bioactive components. Presence of streptomycin like compound by Gas Chromatography Mass Spectrometry led to a breakthrough in the study which had been confined by High Performance Thin Layer Chromatography and Fourier Transform Infra-Red Spectroscopy techniques by comparing with standards. Gene expression studies showed that the selected strain can down regulate the genes in the formation of biofilm by the test organism Pseudomonas aeruginosa. The bioactive compound from Actinokineospora is an ecofriendly product along with a biofilm mitigating activity on medical devices. Rare actinomycetal isolate was able to produce the antibiotic which could apply on medical device to reduce the infections during the treatment. This antibiotic coating on life saving devices will provide the ultimate protection for patients.
In silico and in vitro investigation of the role of Asparagus racemosus lead compound Shatavarin IV and associated silver nanoparticles
Authors: Das Vishnu , Kingsley Danie
Published: November 2023

Antibiotic-resistant microbes are a global threat, necessitating the need for new antibacterials. Bioactive compounds obtained from Asparagus racemosus and silver nanoparticles synthesized from it were tested for antibacterial activity. The nanoparticles exhibited a UV absorbance peak at 415nm. SEM image revealed elliptical nanoparticles from 32.6 nm to 78.6 nm while the FTIR study of aromatic amine N-H and C-O stretching indicates the stability of the silver nanoparticle. Zeta potential and XRD tests confirmed the presence of silver nanoparticles in the root extract under stable conditions. Methanolic root extract and silver nanoparticles were found to be very effective against Bacillus subtilis (20mm), Salmonella typhimurium (20mm), Escherichia coli (20mm), Klebsiella pneumoniae (18mm), Staphylococcus aureus (17mm) and Pseudomonas aeruginosa (15mm) in comparison to ampicillin. AutoDock Tools 1.5.7 was used to perform molecular docking of Shatavarin IV against target proteins involved in breast cancer (PDB ID: 3O96), bacterial infections (PDB ID: 2ZCO), viral infections angiotensin (PDB ID: 4APH) and inflammation (PDB ID: 7PHS). The respective best docking scores are -18.66, -18.07 -14.57 and -15.84 Kcal/Mol respectively. Sarsasapogenin and Kaempferol also showed favorable docking scores with specific target proteins. Shatavarin IV is found to target amino acid(s) and the standard drugs of each category such as Remdesivir for viral, Diclofenac for inflammation, Tamoxifen for cancer and Plazomicin for bacterial infections. This study reveals that Asparagus racemosus bioactive compound Shatavarin IV is a suitable lead compound for the treatment of cancer, viral, bacterial infections and inflammatory conditions.
Non-motile Ciliopathies of the Kidney
Authors: Karikalan Barani , Chakravarthi Srikumar , Kalerammana Prarthana Gopalakrishna
Published: November 2023

Most cells of our body have primary cilia, which are specialised sensory organelles that are present on the apical surface. They have been proven to perform critical roles in tissue formation and signal transmission. Mutations of the genes involved in development and functioning of the cilia result in a group of diseases called as ciliopathies which are defined by organ failure caused by ciliary dysfunction. Numerous mutations result in renal ciliopathies that result in severe kidney diseases caused by ciliary dysfunction. The main emphasis of this review to set of overlapping and genetically heterogeneous disorders called ciliopathies with special emphasis on the renal involvement of these diseases. Renal involvement in these diseases ranges from a simple insignificant renal cyst to severe debilitating renal dysfunction resulting in renal failure in the early stage of the disease.
The productivity and nutritional value of the monoculture and grass mixtures with eastern goat’s rue on drained soil
Authors: Капсамун А.Д. , Павлючик Е.Н. , Иванова Н.Н.
Published: November 2023

Исследования по изучению продуктивности, химического состава и питательной ценности травостоев козлятника восточного сорта Гале (Galega orientalis Lam.) в одновидовых посевах и в смеси со злаковыми травами тимофеевкой луговой ВИК 9 (Phleum pratense) и овсяницей луговой Сахаровская (Festuca pratensis) на выводных полях, рассчитанные на получение 6–8 тыс. корм. ед. с 1 га, проводились в 2019–2021 годах на опытном полигоне Губино ВНИИМЗ в Тверской области. Почва опытного участка осушаемая дерново-подзолистая. Междренное расстояние регулирующей сети — 18–40 м, глубина закладки дрен колебалась от 0,8 до 1,1 м. Учёт продуктивности козлятника восточного в год пользования (2021 год) показал, что наивысшую урожайность зелёной массы в среднем за два укоса обеспечили одновидовые посевы козлятника восточного без внесения минеральных удобрений на глубокооглееной почве — 29,07 т/га; на глеевой почве при внесении минеральных удобрений — 34,24 т/га; на глееватой дерново-подзолистой почве эти показатели возросли и составили 30,43 и 36,77 т/га соответственно. Ещё выше продуктивность козлятника получена на глеевой почве — 30,54 и 41,38 т/га соответственно. Энергетическая ценность 1 кг сухого вещества, полученного в 1-м укосе трав в период бутонизации – начала цветения, была высокой: в одновидовых посевах козлятника восточного она составила 0,96–1,03 корм. ед. и 10,3–10,8 МДж обменной энергии, в смешанных посевах — 0,95–1,03 корм. ед. и 9,05–9,84 МДж обменной энергии. Максимальная обеспеченность 1 корм. ед. переваримым протеином (243 г) была достигнута в одновидовых посевах козлятника восточного

This investigation took place at the All-Russian Research Institute of Meliorated Lands in the Tver region in 2019–2021. The aim was to test the productivity, chemical composition and nutritional value of eastern goat’s rue, Gale (Galega orientalis Lam.) seeded as monoculture or mixed with such gramineous as common timothy, VIK 9 (Phleum pratense) and meadow fescue, Sakharovskaya (Festuca pratensis) on the emergency fields with the planned productivity of 6–8 thousand feed units from 1 ha. The soil of the trial field was drained sod-podzolic. The distance between the drains of the regulatory network — 18–40 m. The drain laying depth ranged from 0.8 to 1.1 m. In 2021 the monoculture provided the highest yield of green mass for 2 cuts on unfertilized gley soil — 29.07 t ha-1; under the application of mineral fertilizers — 34.24 t ha-1; on gley sod-podzolic soil — 30.43 and 36.77 t ha-1, respectively. Eastern goat’s rue had the highest productivity on gley soil — 30.54 and 41.38 t ha-1, respectively. The energy value of 1 kg of DM obtained in the first cut (budding – early flowering) was high: the monoculture provided 0.96–1.03 feed units and 10.3–10.8 MJ of exchange energy, the mixtures — 0.95–1.03 feed units and 9.05–9.84 MJ of exchange energy, respectively. The monoculture of eastern goat’s rue provided the highest yield of digestible protein — 243 g per 1 feed unit.
Efficient algorithms for solving inverse gravimetry and magnetometry problem on graphics processors
Authors: Акимова Е.Н. , Мисилов В.Е. , Третьяков А.И.
Published: November 2023

Работа посвящена алгоритмам решения обратной задачи гравиметрии о восстановлении поверхности раздела сред по гравитационным данным и задачи магнитометрии для случая произвольно направленной намагниченности по магнитным данным и их реализации на графических процессорах. Построены экономичные модифицированные алгоритмы решения обратных задач гравиметрии и магнитометрии на основе метода сопряженных градиентов с использованием теплицево-блочно-теплицевой структуры матрицы производных интегрального оператора. Построен новый покомпонентный метод для решения обратной задачи магнитометрии в случае произвольно направленного вектора намагниченности. Проведены численные эксперименты на GPU для исследования применимости и производительности разработанных алгоритмов.

The work is devoted to algorithms for solving the inverse gravimetry problem of finding an interface between media from gravity data and the magnetometry problem for the case of an arbitrarily directed magnetization from magnetic data and their implementation on graphics processors. Based on the conjugate gradient method using the Toeplitz-block-Toeplitz structure of the matrix of integral operator derivatives, we construct the efficient modified algorithms for solving inverse gravimetry and magnetometry problems. A new componentwise method is elaborated for solving the inverse magnetometry problem for the case of an arbitrarily directed magnetization vector. Numerical experiments are carried out on the GPU to study the applicability and performance of the developed algorithms.
Kinetic Modelling of Cobalt-Catalyzed Propene Hydroformylation: A Combined Ab Initio and Experimental Fitting Protocol
Authors: Guo Luxuan , Harvey Jeremy
Published: November 2023

Kinetic modelling of catalytic reaction systems can yield detailed insight into mechanisms, enabling in particular the identification of rate- and turnover-limiting steps. Empirical models fitted to observed kinetics do not always unambiguously resolve the microscopic nature of the mechanism, while ab initio models with rate constants derived from statistical rate theories and quantum chemistry invariably lead to mismatches between predicted and observed rates, sometimes even to the extent that the dependence of the rate on key variables such as temperature or concentration is incorrect. We have shown previously that when using accurate quantum chemical methods, agreement with experiment of ab initio kinetic models can be good, and can be further improved by performing limited fitting of the ab initio values. Here we show that a detailed assessment of the remaining mismatches with experiment combined with a careful fitting protocol and with additional quantum chemical calculations can yield much improved accuracy and improved microscopic understanding of the reaction mechanism, for the important test case of propene hydroformylation by Co2(CO)8.
ISMER: A Novel Frequency Attenuated Mechanical Metamaterial for High-Magnitude Earthquake Dampening at a Cost-Effective Approach
Authors: Reddy Suraj
Published: November 2023

Materials with special geometrically designed microstructures, referred to as metamaterials, have gained significant attention in the world due to their unique properties of toughness and failure-resistance. The ability to simply alter the internal geometry of almost any material to exponentially increase strength is incredibly enticing due to the feasibility and possibilities of billions of designs that can change the entire scope of how a material behaves. However, mechanical metamaterials have yet to be majorly implemented at a large scale to solve our crucial problems. A major problem the world faces today is producing stronger construction materials to prevent events such as Earthquake collapses, while still maintaining scalability and cost-effectiveness for earthquake prone regions such as Syria and Turkey. This is where ISMER (Internal Structural Modification for Earthquake Resistance), a novel metamaterial design, finds its place in the world of lost-cost earthquake resistance. Convergent Finite Element Analysis methods were used to design and simulate the behavior of a special class of mechanical metamaterials under randomized-seismic loading and 3D printing techniques to fabricate the physical specimens. Afterwards, scaled models and nanoscale mechanics were explored with Scanning Electron Microscopy (SEM), ISMER was improved in terms of magnitude resistance. Within the methods of this study, 8 modular varieties, 2 to 16 units, are considered, as the structure transitions from an hourglass to honeycomb structure as distance increases, with 8 units being a perfectly vertical support and the control. These designs and measurements are proportional to the specimen itself, so ISMER can be implemented into any Newtonian solid. The study resulted in a rich understanding of how to manipulate any material’s strength by manipulating the microscale, in which a mathematical model was postulated, and prototype models were fabricated and tested. It was found that the 16 units case (honeycomb) was the most optimal for a variety of tests such as Frequency Attenuation and Richter Scale Simulations and has major potential to be feasibly implemented into manufacturing of housing materials as it showcased resistance to earthquakes of magnitude 6.
Analisis Kebutuhan Penerima Manfaat Penyuluhan Sastra di Kabupaten Jayapura, Provinsi Papua
Authors: Lestari Ummu Fatimah Ria
Published: November 2023

One of the UPT Badan Bahasa in Papua, Balai Bahasa Provinsi Papua has also conducted literature counseling in various forms so far. The diversity in the implementation of literature counseling by Balai Bahasa Provinsi Papua in Papua is the background to this research. Based on the background previously stated, this research will focus on the needs of beneficiaries of literature counseling in Jayapura Regency. This study aims to formulate the design and construction of literary extension so that it can be carried out in a structured and well-planned manner. In particular, this study aims to analyze the needs of beneficiaries of literary counseling. This research was conducted using a quantitative description approach. In addition to the results of a questionnaire, the data in the study were also supplemented by observations, document scrutiny, and unstructured interviews. Respondents in this study totaled thirty people consisting of students, teachers, university students, and the general public in Jayapura Regency, Papua Province. The needs of the beneficiaries of literary counseling in Jayapura Regency are related to services and literary counseling, the activities of participants in literary counseling, and the environment for literary counseling.