bluuebunny/crossref_metadata_2025 huggingface dataset:
EFFECTIVENESS OF CHIN TUCK AGAINST RESISTANCE (CTAR) IN POST STROKE OROPHARYNGEAL DYSPHAGIA: A META-ANALYSIS STUDY
Authors: Junaeni  , Najma Alythea
Published: July 2023

This study aims to examine the effectiveness of the chin tuck against resistance (CTAR) approach in reducing aspiration and increasing oral intake in individuals with post-stroke swallowing disorders. This study was a systematic review and meta-analytical design. Electronic database in the form of PubMed is used to search related data. Three experimental articles with a randomized controlled trial (RCT) design were included in this study. Based on related results, it is known that CTAR has an effect on reducing aspiration rate (SMD = -1.03; 95% CI -1.72 – -0.35) and it is known that CTAR has an effect on increasing oral intake (SMD = 0.82; 95% CI 0.03 – 1.61) .
Makna ‘’Didiklah Orang Muda’’ menurut Amsal 22:6 dan Relevansinya bagi Gereja
Authors: Deru Immanuela
Published: July 2023

Education is very vital to improve the quality of human resource. Therefore moral and spiritual education is very important for men in order to change the mindset, character, and increasing intelligence. Jesus startyed his ministry educating or teaching (Matthew 4:23). Every one who heard his teaching and believed him always experiences a change of attitude from bad to good (the apostles, Zaccheus, Samaritan woman). The Lord Jesus understood very well that education consists of very important teachings for one’s life. Teaching the Word of God contributed to the growth of the faith of the early church. It even contributed to the growth in quantity (Acts 2:41-42). The first and major Education agent here is the family. Parents are the main teacher for their children. Not only family, but then there is the church for the believers. As one of the assignments of the church is teaching (didache). The church has to teach or educate the people according to the Bible. Christian education needs to have the basic understanding that God is the source of knowledge or the Truth.3 The most important purpose of a Christian education is helping the students to know God through Jesus Christ, through His Word. To be able to achieve this, we need to have educators who deeply know God, through Jesus Christ and have experienced spiritual renewal.

Abstrak

Pendidikan sangat diperlukan untuk meningkatkan mutu dan kualitas sumber daya manusia. Oleh sebab itu pendidikan baik secara moral maupun keagamaan sangat penting bagi seseorang, agar dapat mengubah pola pikir, karakter, dan meningkatkan kecerdasan. Tuhan Yesus memulai pelayanan-Nya di dunia dengan mendidik atau mengajar (Matius 4:23). Setiap orang yang mendengar pengajaran-Nya dan mempercayai-Nya senantiasa mengalami suatu perubahan sikap, yaitu dari yang tidak baik menjadi baik (Para Rasul, Zakheus, Perempuan Samaria). Tuhan Yesus sangat memahami bahwa pendidikan berupa pengajaran sangat penting bagi kehidupan seseorang. Pertumbuhan jemaat mula-mula juga tidak lepas dari peranan pengajaran akan Firman Tuhan, sehingga jemaat mengalami pertumbuhan baik secara kualitas (iman) maupun kuantitas (jumlah) dengan pesat (Kis 2:41-42). Agen pendidikan yang terutama adalah keluarga. Orang tua adalah guru utama bagi para anak-anaknya. Tidak hanya keluarga, agen pendidikan lainnya bagi orang percaya adalah gereja. Salah satu tugas gereja adalah pengajaran (didache). Gereja harus memberikan pengajaran atau didikan yang benar secara Alkitabiah. Pendidikan atau pengajaran kristiani mempunyai pemahaman bahwa Allah adalah sumber pengetahuan dan kebenaran sejati.3 Maka tujuan tertinggi dari pendidikan atu pengajaran kristeaniadalah membantu peserta didik untuk belajar mengenal Allah di dalam Yesus Kristus melalui firman-Nya. Untuk mencapai tujuan itu, tentunya diperlukan pendidik yang sungguh-sungguh mengenal Allah di dalam Yesus Kristus dan mengalami pembaharuan secara spritual.
Peran Malaikat Berdasarkan Kisah Para Rasul 12:5-12
Authors: Elkana Samuel
Published: July 2023

All human beings must have experienced times of darkness and gloom, wilderness, sadness, fear or disappointment. Especially in our day that is filled with worldwide suffering. Likewise these days, the phenomenon of the spirit world is increasingly widespread and has become the attention of quite a number of Christians in this end of time. Like some people with horoscopes, palm readers, and all kinds of new age teaching. Christian faith must remain firm to believe that to this day angels are still actively sent by God to help believers. The author uses qualitative research methods in the form of exegesis and literature studies to explain that the example of the role of angels according to Acts 12:5-12 is very important for the life of a believer.  AbstrakSemua manusia pasti pernah mengalami saat-saat yang gelap dan suram, padang belantara, keadaan sedih, takut atau kecewa. Terutama sekali di zaman kita sekarang ini dipenuhi dengan penderitaan yang mendunia. Demikian juga hari-hari ini, fenomena dunia roh semakin marak dan menjadi perhatian cukup banyak orang Kristen di akhir zaman ini.  Seperti halnya beberapa orang yang dengan horoskop, pembaca telapak tangan, dan segala macam pengajaran zaman baru. Iman Kristen harus tetap teguh untuk percaya bahwa sampai hari ini para malaikat masih aktif diutus oleh Tuhan untuk membantu orang percaya. Penulis menggunakan metode penelitian kualitatif berupa eksegesa dan studi literatur untuk menjelaskan bahwa contoh peran malaikat menurut Kisah 12:5-12 sangat penting bagi kehidupan orang percaya.
Providensia Allah dalam Kitab Ayub
Authors: Subekti Tri
Published: July 2023

control of every human life, history, existence and order of the universe. God's extraordinary involvement in human life, especially in the book of Job, is in the form of providence or God's care and provision for Job. The book of Job discusses how Job experienced God's extraordinary providence in his life and family. The author uses the literature study method to describe the form of God's providence in the book of Job. Through literature studies by reading books, the author can formulate a useful view of the existence of God in the book of Job. AbstrakAllah menguji iman seseorang melalui masalah yang datang bertubi-tubi dalam kehidupan. Allah berdaulat dan memegang kendali atas kehidupan setiap manusia, sejarah, keberadaan dan tatanan alam semesta. Keterlibatan Allah yang luar biasa dalam kehidupan manusia khususnya dalam kitab Ayub yaitu berupa providensia atau pemeliharaan dan penyediaan Allah terhadap Ayub. Kitab Ayub membahas bagaimana Ayub mengalami providensia Allah yang luar biasa dalam hidup dan keluarganya. Penulis menggunakan metode studi literatur untuk mendiskripsikan bentuk providensia Allah dalam kitab Ayub. Melalui kajian Pustaka dengan membaca buku-buku maka penulis dapat merumuskan suatu pandangan yang bermanfaat tentang proidensia Allah dalam kitab Ayub.
Mandat Ilahi dalam Hukum Kasih Menurut Matius 22:39
Authors: Elkana Samuel
Published: July 2023

God's command to obtain eternal life is by doing the law of love. The mandate to love God and neighbor was given to mankind. Sometimes humans fail to carry out the divine mandate regarding the law of love because of a lack of understanding of the law of love. This research explains comprehensively and theologically by using qualitative methods, namely literature studies.AbstrakPerintah Tuhan untuk memperoleh hidup yang kekal yaitu dengan melakukan hukum kasih. Mandat mengasihi Allah dan sesasma diberikan kepada umat manusia. Terkadang manusia gagal dalam melakukan mandat ilahi tentang hukum kasih karena kurangnya pemahaman tentang hukum kasih. Dalam penelitian ini menjelaskan secara konprehensif dan teologis dengan menggunakan metode kualitatif yaitu studi Pustaka atau literatur.
Mechanics of Linguistic Mobility in COVID-19 Pandemic: Lexical innovation and richness
Authors: Sami Al-Heeh  , Ameer Salameh  , Saif Abu-Srour
Published: July 2023

This small-scale study investigates ‘Mechanics of Linguistic Mobility in COVID-19 Pandemic: Lexical innovation and richness’. Thus, it generally studies the language native speakers of English have innovated and developed during the ongoing global crisis. In particular, it aims to quantify these terms, identify the morphological processes that facilitate the derivation of these phrases, and explain the reasons lying behind their selection and uses. Methodologically, the study fits into the qualitative research. For data collection, the study benefits from corpus linguistics, i.e. studies of large bodies of texts. Therefore, a concordance of key words in context (KWIC) has been carried out on the British National Corpora (BNC) and other lexicographic sites to build a corpus of corona language. Analytically, the study builds on critical discourse analysis (CDA) at the semantic, morphological and schematic, i.e. discourse level of words and phrases used during the crisis. It has been found that the terms and expressions used during the crisis are either coined to convey new senses or altered to satisfy certain meanings related to the pandemic. The morphological processes vary considerably between compounding, clipping, inflection and coining. The social domains in which the invented terms are used include family, education, health, psychology, sociology, business, politics, and religion.
Israel's International Legal Responsibility for Human Rights Violations in the Occupied Palestinian Territory In accordance with the provisions of international law
Authors: Najah Duqmaq
Published: July 2023

The West Bank, Gaza Strip, and the city of Jerusalem are occupied territories occupied by Israel following hostilities in the 1967 war. Israel was a State party to the Fourth Geneva Convention of 1949, which refused to apply it to the occupied territories since the common article I of the four Geneva Conventions showed respect for and universal adherence to the principles contained therein. However, Israel has not complied with this but has committed serious violations of the rights of Palestinian citizens, criminalized under the Rome Statute of the International Criminal Court. The research aims to hold Israel internationally responsible for its illegal actions in the occupied Palestinian territories for violating the provisions of international law and resolutions of international legitimacy. The importance of the search for international criminal and civil accountability of Israel for its human rights violations in the Occupied Palestinian Territories is important, as Palestine's accession to the International Criminal Court comes as an important step in terms of ending the impunity of Israeli war criminals in addition to prosecuting them wherever they are regardless of their nationality and the place where the crime was committed in accordance with universal jurisdiction. The problem of the research revolves around: How long will Israel remain without international accountability for its violations of the rights of citizens in the Occupied Palestinian Territory? The researcher followed the descriptive and analytical approach and reached a set of conclusions and recommendations, the most prominent of which are: holding Israel internationally responsible for its internationally wrongful actions in the occupied Palestinian territories represented by the violation of international obligations. Among the most prominent recommendations are the implementation of the recommendations of Amnesty International's report regarding the call of the International Criminal Court to consider the crime of apartheid as part of its investigations into the Palestinian situation before it and that all States exercise universal jurisdiction to bring the perpetrators of apartheid crimes to justice.
Palestinian Legislation Governing the Rights of Persons with Disabilities In light of International Conventions "Legislative Alignments"
Authors: Saeed Abu Fara  , Mohammed Z. Jaradat
Published: July 2023

The principle of equality is fundamental in the democratic state and the rule of Law. According to this principle, the state takes care of all categories of human society, especially persons with disabilities. As a result, the national Legislation regulates the rights of persons with disabilities in parallel with international Legislation; the state will get a prominent position in the international community. The International Convention on the Rights of Persons with Disabilities of 2006 was the first comprehensive and general regulation of the rights of persons with disabilities. This is the center of our research through reading it with the relevant Palestinian national Legislation, especially the Persons with Disabilities Law of 1999. The importance of this study is that it examines the extent of the shortcomings of national Legislation for an important group of Palestinian society which is persons with disabilities, in order to provide advice to specialists to move towards a law that provides a better life for persons with disabilities. This study followed the descriptive, analytical, and comparative approach by being exposed to the Palestinian Legislation and comparing it with the texts of international conventions. The study concluded with a set of results. The most notable is that the right to equality and non-discrimination is one of the most important rights dealt with in international conventions and national Legislation. Besides, one of the most important recommendations was the necessity of establishing a separate chapter for people with disabilities related to rights and freedoms, whether in the current basic Palestinian Law or in the future constitution.
Assessment of Unjustified Brain Ct Requests in The Emergency Room of The Public Health Care System in Palestine Case Study: Hebron Governmental Hospital
Authors: Khaled Sabarna  , Mysara Rumman  , Aroub Salah Aldin  , Suhaib Tamim  , Batoul Alayan
Published: July 2023

Computed tomography (CT), which gives doctors a precise cross-sectional image that clearly shows the features of the organs, is one of the most crucial pieces of medical imaging equipment. In contrast to other equipment, the CT scan may expose the patient to a very high dose of radiation. As a result of the hazards associated with imaging patients, the use of CT images must be restricted, especially when imaging the head. The aim of the study is to the evaluation of the percentage of unjustified brain CT requests at the emergency rooms of the governmental health sector in Palestine. The 1957-built Hebron Governmental Hospital (HGH) was chosen as a research study case with a clinical capacity of 237 beds and 596 staff members; it is one of the key Palestinian government hospitals currently operating in the Hebron Governorate of the West Bank-Palestine. Samples were taken from the hospital's emergency room between the first of the year and the end of the year in 2021. 6152 or so brain CT images were gathered. Following that, 500 instances were picked for the investigation. Radiologists were asked to assess 100 of these 500 cases to determine whether the patient needed a scan or not. According to the study, 78% of brain tomography images were for unjustifiable reasons. Additionally, it was revealed by the study's results that unnecessary head CT scans were more common than those from retrospective investigations. In particular, non-specialized doctors who request cross-sectional brain imaging for no apparent reason are to blame for this because of their lack of knowledge.
The role of the death penalty in preventing murder in Palestinian society according to the theories of deterrence and rational choice
Authors: Esam Al-Atras
Published: July 2023

This study aimed to identify the role of the death penalty in preventing murders in Palestinian society according to the theories of deterrence and rational choice. Furthermore, there is an international trend to abolish the death penalty as a result of the development and globalization of human rights concepts. The death penalty also contributes to achieving special deterrence for the perpetrators of murder by ending the life of the criminal, which prevents his ability to commit another murder. The death penalty also contributes. To achieve special deterrence for all people with regard to murder crimes by the availability of the elements of the effectiveness of punishment, namely its severity, clarity, and certainty of its application. During the trial of those accused of committing murder, the study also recommended the need for the Palestinian legislator to reconsider the abolition of the death penalty in the draft Palestinian Penal Code and to maintain it due to its role in achieving public deterrence.
Desarrollo y validación de un Framework para el análisis del trabajo colaborativo virtual
Authors: Temporelli Walter
Published: July 2023

La inclusión de aspectos colaborativos, la mediación por tecnologías y la educación a distancia ha problematizado la noción del aprendizaje y, a su vez, ha generado nuevos interrogantes acerca de cómo estudiar este proceso. Debido a eso, nuestro trabajo desarrolla y valida un marco de referencia que colabore con el análisis de cuáles son las mejores variables que intervengan en el trabajo colaborativo a través de una computadora. El ámbito del Computer-Supported Collaborative Learning (aprendizaje colaborativo soportado por computadora) tiene una historia de debate acerca de sus teorías, sus métodos y su definición. A partir del marco teórico, desarrollamos una primera versión de nuestro framework, luego, lo sometimos al análisis de un jurado para armar una segunda versión y aplicarla a nuestro campo de estudio. Concluimos que las dimensiones que mejor visibilizan las acciones que facilitan o obstaculizan la colaboración en redes virtuales educativas son la agentividad, el conocimiento metacognitivo y el proceso de regulación de los aprendizajes.
Influencia del paso del tiempo en las herramientas digitales educativas: obsolescencia percibida
Authors: Vergara Rodríguez Diego , Fernández-Arias Pablo , Extremera Nedjar Jamil , Rubio Cavero Manuel Pablo
Published: July 2023

Las tecnologías educativas están sometidas a un rápido proceso de obsolescencia y, aunque a nivel didáctico pudieran seguir siendo igual de eficaces que como lo fueron desde el día de su creación, a nivel de motivación pueden generar un rechazo por parte del alumnado al encontrarlas obsoletas. Este artículo presenta cómo la experiencia del usuario (user experience, UX) en una plataforma virtual interactiva (PVI) basada en la realidad virtual puede afectar al proceso de enseñanza-aprendizaje para el que inicialmente fue diseñada. Los resultados revelan un decaimiento progresivo en la valoración del alumnado tanto en el grado de motivación como en la valoración de la interactividad con la PVI, es decir, evidencian un claro proceso de obsolescencia. Además, este artículo demuestra cómo la actualización de esta PVI con un diseño actual favorece la UX recuperando en los estudiantes el nivel alcanzado antes de iniciarse el proceso de obsolescencia.
El taller fotográfico como dinamizador de la consciencia del mirar
Authors: Zapata Ramírez John Alexander
Published: July 2023

El presente artículo da a conocer la experiencia de un taller fotográfico, realizado con estudiantes de grado quinto en la Unidad Educativa San Marcos de Envigado-Colombia, en el marco de la asignatura Lengua castellana. Este espacio se presenta como una aproximación a la recepción estética de la imagen y al reconocimiento del otro y del entorno que nos rodea, mediados por la imagen fotográfica como dinamizadora de la consciencia del mirar. Es, a su vez, una reflexión de la lectura de otros sistemas simbólicos y la producción de la imagen fotográfica como un acto estético dentro de la educación primaria.

Palabras clave: mirada, fotografía, estética, imagen, lenguaje.
Penerapan Pembiasaan Kegiatan Keagamaan dalam Membentuk Karakter Disiplin Siswa di SMPN 17 Pekanbaru
Authors: Aisy Funny Radiatul , Sukmawati  , Syafi'i Muhammad
Published: July 2023

Instilling character education, especially discipline, is an important thing to instill in students from a young age. The purpose of this study was to determine the objective conditions of the habituation of religious activities, to know the discipline and religious character of students, and to know the influence of the habituation of religious activities on the character of student discipline at SMPN 17 Pekanbaru. This research is a qualitative descriptive study using observation and documentation data collection techniques. The results showed that the habituation of religious activities at SMPN 17 Pekanbaru had a significant effect on student discipline.
Validitas dan Reliabilitas Butir Soal Berbasis Kemampuan Berpikir Kritis Pada Materi Listrik Dinamis
Authors: Ika Ningtiyas Retno , Sahal Muhammad , Gusmeri Yeni
Published: July 2023

The purpose of this research is to develop questions based on critical thinking on dynamic electricity material and to determine the feasibility of the questions developed in terms of validity and reliability aspects. This type of research is development work according to the R&K (Research and Development) model. The research sample consisted of 24 students. From the test results it is known that the questions developed are declared valid and reliable. The aspect of validity consists of internal validity and external validity, where internal validity is carried out by a validator whose level of validity is in the good category and is suitable for use subject to previous controls. At the same time, external validity was carried out by testing a number of students. The result is 16 out of 24 questions declared valid. Next is the reliability factor with a score of 0.81. This value is greater than 0.8 so that it is declared reliable and is in the very high category.
Pemanfaatan Media Pembelajaran Aplikasi Quizizz dalam Meningkatkan Motivasi dan Hasil Belajar Siswa SMK Migas Bumi Melayu Riau
Authors: Ramadhani  , Suryani Putri Esti , Syafi'i Muhammad
Published: July 2023

Education is one aspect that is very influential in the quality of human resources in a country. Improving the quality of education will improve the quality of human resources in the country. Success in carrying out learning activities can be seen from the results achieved by students. One of the efforts made to see the success of learning activities is to use learning methods that can attract the attention of students. Learning methods that utilize current technological developments can be used to increase student motivation and learning outcomes, one of the methods that can be used is by using the Quizizz application as a learning medium that can attract students' attention. Quizizz is an application that can be used as a medium for learning activities. This application combines education, games and technology. The purpose of this study is to describe how the use of the Quizizz application affects student motivation and learning outcomes. This study uses observation and descriptive methods. The approach used is a qualitative approach with descriptive data. Descriptive data, namely data collected from research results using words. The results of research using Quizizz are very effective in the process of learning activities at SMK MIGAS Bumi Melayu Riau.
Babur ve Bayram Han Dîvânlarındaki Deyimler
Authors: KARATAŞ Ahmet
Published: July 2023

Deyimler, bir duyguyu ya da düşünceyi daha etkili ve özlü bir biçimde ifade etmeye yarayan kalıplaşmış söz öbekleridir. Deyimlerin oluşumunda en az iki sözcük yer almalı ve bu sözcüklerden en az birinin gerçek anlamının dışında bir anlama sahip olması gerekmektedir. Bu şekilde oluşmuş deyimler, kalabalık söz kadrosuyla anlatılacak ifadeyi, daha kısa ve etkili bir yolla ifade etmekte ve konu üzerinde derinlemesine düşünmeyi sağlamaktadır.

Türkçe, deyimlerin varlığı bakımından son derece zengin bir dildir. Türkçenin ilk yazılı metinlerini oluşturan Orhun Yazıtlarından itibaren, günümüze değin oluşturulmuş hemen hemen her eserin söz varlığında deyimlerin varsıllığı dikkati çekmektedir.

Babur ve Bayram Han, Hindistan’da gelişen Türk edebiyatının öncü isimleri olmakla birlikte, aynı zamanda Babur Türk-Hint İmparatorluğu’nun saray erkanına bağlı önemli simalarıdır. Bu çalışmada, Babur ve Bayram Han’ın dîvânlarındaki, Türkçe’nin inceliklerini gösteren söz öbeklerinden olan deyimler tespit edilmiştir. Çalışmada, deyim ile ilgili birtakım bilgiler verildikten sonra eserlerde geçen deyimlerin yapı bakımından tasnifi yapılmıştır. Deyimlerin yapı yönünden incelenmesinde Zeynep Korkmaz’ın “Türkiye Türkçesi Grameri Şekil Bilgisi” adlı eserinde yaptığı sınıflandırma örnek alınmıştır. Daha sonra bu deyimler, kökenleri bakımından ayrı bir sınıflandırmaya daha tabi tutulmuştur. Çalışmanın ekinde ise deyimler, alfabe sıralamasına göre sırasıyla dizilmiş ve deyimlerin anlamları verilmiştir. Ayrıca tespiti yapılan deyimlerin, eserde geçtikleri yerler numaralandırılarak kullanım sıklığı belirtilmiştir.
L’anecdote curieuse au service de la propagande politique française dans les « Relations de Canada » (1705-1713)
Authors: Gladu Kim , De Montigny Jacinthe
Published: July 2023

Entre 1705 et 1713, en pleine guerre de Succession d’Espagne, le Mercure galant publie une série de 11 « Relations de Canada » où prédomine le discours anecdotique, ce qui les distingue des autres relations de voyage publiées dans le même périodique durant la précédente décennie. L’anecdote vient modifier le genre même de la relation de voyage en misant sur la curiosité comme moteur de production et en proposant une histoire du temps présent où l’actualité coloniale occupe la meilleure place. Par ailleurs, le récit anecdotique fait l’objet d’une récupération politique et inscrit la relation de voyage dans le champ de la propagande. Les diverses figures que mettent en scène les « Relations de Canada » contribuent ainsi à faire valoir les entreprises louis-quatorziennes en Amérique, en montrant la supériorité des Français sur les Britanniques.
« Entrez bien, Monsieur, dans le style, vous allez devenir sauvage en lisant ceci »
Authors: Bernier Marc André
Published: July 2023

En février 1706, un numéro du Mercure galant propose à ses lecteurs le récit d’un « Accommodement fait entre les Iroquois et les Outaouais en 1705 ». À l’occasion de cette négociation, les propos sont rédigés, comme l’écrit le rédacteur du Mercure galant, en « style sauvage ». La manière dont ce style est caractérisé et la fonction qu’il occupe dans ce récit invitent à s’interroger sur l’imaginaire colonial de la presse d’actualité. Cet article analyse ainsi le rôle essentiel que joue le temps historique court de la mode et du moment présent dans la construction de la figure de l’Autre.
Bâtir une GRH inclusive en PME au travers des relations de don/contre-don entre dirigeant et salariés
Authors: Adla Ludivine , Gallego-Roquelaure Virginie
Published: July 2023

Évoluant dans des contextes économique et géopolitique turbulents, des questions sociales s’ajoutent aux difficultés quotidiennes des PME. Certains dirigeants sont donc amenés à concilier leurs différentes préoccupations, tout en replaçant les salariés au coeur de l’organisation. Autrement dit, il s’agit de mieux prendre en compte leurs attentes et de les faire participer aux décisions relatives à la gestion des ressources humaines. Dans cette optique, l’émergence d’une GRH inclusive, favorisant l’épanouissement professionnel et la reconnaissance de chaque salarié, s’invite en PME.

Ainsi, notre étude exploratoire apporte des éléments de réponse à sa construction, tout en remettant en question certaines croyances établies. En effet, à travers la logique du don, nous montrons que cette GRH repose principalement sur des relations d’échange, qui ne sont pas exemptes de difficultés.

Résumé

Cet article vise à comprendre l’émergence et le développement d’une gestion des ressources humaines (GRH) inclusive en PME. Le concept d’inclusion renvoie à l’épanouissement professionnel et à la reconnaissance des salariés (Bonneveux et al., 2020). Cette forme de GRH comporte une visée intégrative dans la mesure où elle offre la possibilité d’améliorer la collaboration notamment entre le dirigeant et ses salariés. Dans cette optique, nous avons mobilisé de façon originale la logique du don de Mauss, couplée à la littérature sur la GRH en PME afin de proposer une nouvelle grille de lecture. À partir du cas emblématique d’une PME, une étude qualitative longitudinale a été menée sur une période de 8 ans.

Les résultats soulignent le décalage entre les contre-dons attendus et ceux réellement réalisés par le dirigeant, qui conditionnent in fine l’adonnement des salariés. Ce déséquilibre dans la relation amène à la construction d’une GRH inclusive.
Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons
Authors: Petroccione Maurice A , D'Brant Lianna Y , Affinnih Nurat , Wehrle Patrick H , Todd Gabrielle C , Zahid Shergil , Chesbro Haley E , Tschang Ian L , Scimemi Annalisa
Published: July 2023

Understanding the function of glutamate transporters has broad implications for explaining how neurons integrate information and relay it through complex neuronal circuits. Most of what is currently known about glutamate transporters, specifically their ability to maintain glutamate homeostasis and limit glutamate diffusion away from the synaptic cleft, is based on studies of glial glutamate transporters. By contrast, little is known about the functional implications of neuronal glutamate transporters. The neuronal glutamate transporter EAAC1 is widely expressed throughout the brain, particularly in the striatum, the primary input nucleus of the basal ganglia, a region implicated with movement execution and reward. Here, we show that EAAC1 limits synaptic excitation onto a population of striatal medium spiny neurons identified for their expression of D1 dopamine receptors (D1-MSNs). In these cells, EAAC1 also contributes to strengthen lateral inhibition from other D1-MSNs. Together, these effects contribute to reduce the gain of the input-output relationship and increase the offset at increasing levels of synaptic inhibition in D1-MSNs. By reducing the sensitivity and dynamic range of action potential firing in D1-MSNs, EAAC1 limits the propensity of mice to rapidly switch between behaviors associated with different reward probabilities. Together, these findings shed light on some important molecular and cellular mechanisms implicated with behavior flexibility in mice.
Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor
Authors: Ciampa Erin J. , Flahardy Padraich , Srinivasan Harini , Jacobs Christopher , Tsai Linus , Karumanchi S. Ananth , Parikh Samir M.
Published: July 2023

Most cases of preterm labor have unknown cause, and the burden of preterm birth is immense. Placental aging has been proposed to promote labor onset, but specific mechanisms remain elusive. We report findings stemming from unbiased transcriptomic analysis of mouse placenta, which revealed that hypoxia-inducible factor 1 (HIF-1) stabilization is a hallmark of advanced gestational timepoints, accompanied by mitochondrial dysregulation and cellular senescence; we detected similar effects in aging human placenta. In parallel in primary mouse trophoblasts and human choriocarcinoma cells, we modeled HIF-1 induction and demonstrated resultant mitochondrial dysfunction and cellular senescence. Transcriptomic analysis revealed that HIF-1 stabilization recapitulated gene signatures observed in aged placenta. Further, conditioned media from trophoblasts following HIF-1 induction promoted contractility in immortalized uterine myocytes, suggesting a mechanism by which the aging placenta may drive the transition from uterine quiescence to contractility at the onset of labor. Finally, pharmacological induction of HIF-1 via intraperitoneal administration of dimethyloxalyl glycine (DMOG) to pregnant mice caused preterm labor. These results provide clear evidence for placental aging in normal pregnancy, and demonstrate how HIF-1 signaling in late gestation may be a causal determinant of the mitochondrial dysfunction and senescence observed within the trophoblast as well as a trigger for uterine contraction.
Differential increase of hippocampal subfield volume after socio-affective mental training relates to reductions in diurnal cortisol
Authors: Valk Sofie Louise , Engert Veronika , Puhlmann Lara , Linz Roman , Caldairou Benoit , Bernasconi Andrea , Bernasconi Neda , Bernhardt Boris C , Singer Tania
Published: July 2023

The hippocampus is a central modulator of the HPA-axis, impacting the regulation of stress on brain structure, function, and behavior. The current study assessed whether three different types of 3 months mental Training Modules geared towards nurturing (a) attention-based mindfulness, (b) socio-affective, or (c) socio-cognitive skills may impact hippocampal organization by reducing stress. We evaluated mental training-induced changes in hippocampal subfield volume and intrinsic functional connectivity, by combining longitudinal structural and resting-state fMRI connectivity analysis in 332 healthy adults. We related these changes to changes in diurnal and chronic cortisol levels. We observed increases in bilateral cornu ammonis volume (CA1-3) following the 3 months compassion-based module targeting socio-affective skills (Affect module), as compared to socio-cognitive skills (Perspective module) or a waitlist cohort with no training intervention. Structural changes were paralleled by relative increases in functional connectivity of CA1-3 when fostering socio-affective as compared to socio-cognitive skills. Furthermore, training-induced changes in CA1-3 structure and function consistently correlated with reductions in cortisol output. Notably, using a multivariate approach, we found that other subfields that did not show group-level changes also contributed to changes in cortisol levels. Overall, we provide a link between a socio-emotional behavioural intervention, changes in hippocampal subfield structure and function, and reductions in cortisol in healthy adults.
Hippocampal subfield CA1-3 shows differential structural and functional network plasticity after stress-reducing socio-affective mental training
Authors: Valk Sofie L. , Engert Veronika , Puhlmann Lara , Linz Roman , Caldairou Benoit , Bernasconi Andrea , Bernasconi Neda , Bernhardt Boris C. , Singer Tania
Published: July 2023

The hippocampus forms a central modulator of the HPA-axis, impacting the regulation of stress on brain structure, function, and behavior. The current study assessed whether three different types of 3-months mental training modules geared towards nurturing a) attention-based mindfulness, b) socio-affective skills, or c) socio-cognitive abilities may impact hippocampal integrity by reducing stress. We evaluated mental training-induced changes in hippocampal subfield volume and intrinsic functional connectivity, based on resting-state fMRI connectivity analysis in a group of healthy adults (N=332). We then related these changes to changes in diurnal and chronic cortisol levels. We observed increases in bilateral cornu ammonis volume (CA1-3) following the 3-months compassion-based module targeting socio-affective skills (Affect module), as compared to socio-cognitive skills (Perspective module) or a waitlist cohort that did not undergo an intervention. Structural changes were paralleled by increases in functional connectivity of CA1-3 when fostering socio-affective as compared to socio-cognitive skills. Moreover, training-related changes in CA1-3 structure and function consistently correlated with reduction in cortisol output. In sum, we provide a link between socio-emotional behavioral intervention, CA1-3 structure and function, and cortisol reductions in healthy adults.
DYRK1A Interacts with the Tuberous Sclerosis Complex and Promotes mTORC1 Activity
Authors: Wang Pinhua , Sarkar Sunayana , Huan Zhang Meng , Zhang Zhe , Balasubramanian Deepa , Jayaram Nandan , Datta Sayantan , He Ruyu , Wu Ping , Chao Peng , Zhang Ying , Washburn Michael P. , Florens Laurence , Nagarkar-Jaiswal Sonal , Jaiswal Manish , Mohan Man
Published: July 2023

DYRK1A, a ubiquitously expressed kinase, is linked to the dominant intellectual developmental disorder, microcephaly and Down syndrome in humans. It regulates numerous cellular processes such cell cycle, vesicle trafficking and microtubule assembly. DYRK1A is a critical regulator of organ growth, however, how it regulates organ growth is not fully understood. Here we show that knockdown of
DYRK1A
results in reduced cell size, which is dependent on mTORC1. Using proteomic approaches, we found that DYRK1A interacts with the Tuberous sclerosis complex (TSC) proteins, namely TSC1 and TSC2, which negatively regulate mTORC1 activation. Further, we show that DYRK1A phosphorylates TSC2 at T1462, a modification that is known to inhibit TSC activity and promote mTORC1 activity. We also found that the reduced cell growth upon knockdown of DYRK1A can be rescued by overexpression of RHEB, an activator of mTORC1. Our findings suggest that DYRK1A inhibits TSC complex activity through an inhibitory phosphorylation on TSC2 and thereby promotes mTORC1 activity. Further, using
Drosophila
neuromuscular junction as model, we show that the
mnb
, the fly homologues of
DYRK1A
, is rescued by RHEB overexpression suggesting a conserved role of
DYRK1A
in TORC1 regulation.
C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy
Authors: Zhang Hui , Li Chan , Liu Qingyang , Li Jingmei , Wu Hao , Xu Rui , Sun Yidan , Cheng Ming , Zhao Xiaoe , Pan Menghao , Wei Qiang , Ma Baohua
Published: July 2023

The overall oocyte quality declines with aging, and this effect is strongly associated with a higher reactive oxygen species (ROS) level and the resultant oxidative damage. C-type natriuretic peptide (CNP) is a well-characterized physiological meiotic inhibitor that has been successfully used to improve immature oocyte quality during in vitro maturation. However, the underlying roles of CNP in maternally aged oocytes have not been reported. Here, we found that the age-related reduction in the serum CNP concentration was highly correlated with decreased oocyte quality. Treatment with exogenous CNP promoted follicle growth and ovulation in aged mice and enhanced meiotic competency and fertilization ability. Interestingly, the cytoplasmic maturation of aged oocytes was thoroughly improved by CNP treatment, as assessed by spindle/chromosome morphology and redistribution of organelles (mitochondria, the endoplasmic reticulum, cortical granules, and the Golgi apparatus). CNP treatment also ameliorated DNA damage and apoptosis caused by ROS accumulation in aged oocytes. Importantly, oocyte RNA-seq revealed that the beneficial effect of CNP on aged oocytes was mediated by restoration of mitochondrial oxidative phosphorylation, eliminating excessive mitophagy. CNP reversed the defective phenotypes in aged oocytes by alleviating oxidative damage and suppressing excessive PINK1/Parkin-mediated mitophagy. Mechanistically, CNP functioned as a cAMP/PKA pathway modulator to decrease PINK1 stability and inhibit Parkin recruitment. In summary, our results demonstrated that CNP supplementation constitutes an alternative therapeutic approach for advanced maternal age-related oocyte deterioration and may improve the overall success rates of clinically assisted reproduction in older women.
Trends in self-citation rates in Neuroscience literature
Authors: Rosenblatt Matthew , Mehta Saloni , Peterson Hannah , Dadashkarimi Javid , Rodriguez Raimundo X. , Foster Maya L. , Adkinson Brendan D. , Liang Qinghao , Kimble Violet M. , Ye Jean , McCusker Marie C. , Farruggia Michael C. , Rolison Max , Westwater Margaret L. , Jiang Rongtao , Noble Stephanie , Scheinost Dustin
Published: July 2023

Citation metrics influence academic reputation and career trajectories. Recent works have highlighted flaws in citation practices in the Neurosciences, such as the under-citation of women. However, self-citation rates—or how much authors cite themselves—have not yet been comprehensively investigated in the Neurosciences. This work characterizes self-citation rates in basic, translational, and clinical Neuroscience literature by collating 157,001 articles from 63 journals between the years 2000-2020. In analyzing over eight million citations, we demonstrate four key findings: 1) since 2000, self-citation rates of Last Authors are increasing relative to those of First Authors, 2) the odds of “highly self-citing” articles from authors in the Americas are 2.65, 2.17, 1.35, and 1.43 times those of authors affiliated with Africa, Asia, Europe, and Oceania, 3) men tend to cite themselves more than women early in their careers but less later in their careers, and 4) self-citation rates vary across three major fields (Neurology, Neuroscience, Psychiatry) and 13 subfields. Our characterization of self-citation provides insight into citation practices that shape the perceived influence of authors in the Neurosciences, which in turn may impact what type of scientific research is done and who gets the opportunity to do it.
SNAP25 disease mutations change the energy landscape for synaptic exocytosis due to aberrant SNARE interactions
Authors: Kádková Anna , Murach Jacqueline , Østergaard Maiken , Malsam Andrea , Malsam Jörg , Lolicato Fabio , Nickel Walter , Söllner Thomas H , Sørensen Jakob Balslev
Published: July 2023

SNAP25 is one of three neuronal SNAREs driving synaptic vesicle exocytosis. We studied three mutations in SNAP25 that cause epileptic encephalopathy: V48F, and D166Y in the synaptotagmin-1 (Syt1)-binding interface, and I67N, which destabilizes the SNARE complex. All three mutations reduced Syt1-dependent vesicle docking to SNARE-carrying liposomes and Ca2+-stimulated membrane fusion in vitro and when expressed in mouse hippocampal neurons. The V48F and D166Y mutants (with potency D166Y > V48F) led to reduced readily releasable pool (RRP) size, due to increased spontaneous (miniature Excitatory Postsynaptic Current, mEPSC) release and decreased priming rates. These mutations lowered the energy barrier for fusion and increased the release probability, which are gain-of-function features not found in Syt1 knockout (KO) neurons; normalized mEPSC release rates were higher (potency D166Y > V48F) than in the Syt1 KO. These mutations (potency D166Y > V48F) increased spontaneous association to partner SNAREs, resulting in unregulated membrane fusion. In contrast, the I67N mutant decreased mEPSC frequency and evoked EPSC amplitudes due to an increase in the height of the energy barrier for fusion, whereas the RRP size was unaffected. This could be partly compensated by positive charges lowering the energy barrier. Overall, pathogenic mutations in SNAP25 cause complex changes in the energy landscape for priming and fusion.
SNAP25 disease mutations change the energy landscape for synaptic exocytosis due to aberrant SNARE interactions
Authors: Kádková Anna , Murach Jacqueline , Pedersen Maiken Ø. , Malsam Andrea , Malsam Jörg , Söllner Thomas H. , Sørensen Jakob B.
Published: July 2023

SNAP25 is one of three neuronal SNAREs driving synaptic vesicle exocytosis. We studied three mutations in SNAP25 that cause epileptic encephalopathy: V48F, and D166Y in the Synaptotagmin-1 (Syt1) binding interface, and I67N, which destabilizes the SNARE-complex. All three mutations reduced Syt1-dependent vesicle docking to SNARE-carrying liposomes and Ca
2+
-stimulated membrane fusion
in vitro
and in neurons. The V48F and D166Y mutants (with potency D166Y > V48F) led to reduced Readily Releasable Pool (RRP) size, due to increased spontaneous (mEPSC) release and decreased priming rates. These mutations lowered the energy barrier for fusion and increased the release probability, which are gain-of-function features not found in
Syt1
knockout (KO) neurons; normalized mEPSC release rates were higher (potency D166Y>V48F) than in the
Syt1
KO. These mutations (potency D166Y > V48F) increased spontaneous association to partner SNAREs, resulting in unregulated membrane fusion. In contrast, the I67N mutant decreased mEPSC frequency and EPSC amplitudes due to an increase in the apparent height of the energy barrier for fusion, whereas the RRP size was unaffected. This could be partly compensated by positive charges lowering the energy barrier. Overall, pathogenic mutations in SNAP25 cause complex changes in the energy landscape for priming and fusion.
Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues
Authors: Zhou Mingqi , Tamburini Ian , Van Cassandra , Molendijk Jeffrey , Nguyen Christy M , Chang Ivan Yao-Yi , Johnson Casey , Velez Leandro M , Cheon Youngseo , Yeo Reichelle , Bae Hosung , Le Johnny , Larson Natalie , Pulido Ron , Nascimento-Filho Carlos HV , Jang Cholsoon , Marazzi Ivan , Justice Jamie , Pannunzio Nicholas , Hevener Andrea L , Sparks Lauren , Kershaw Erin E , Nicholas Dequina , Parker Benjamin L , Masri Selma , Seldin Marcus M
Published: July 2023

Inter-organ communication is a vital process to maintain physiologic homeostasis, and its dysregulation contributes to many human diseases. Given that circulating bioactive factors are stable in serum, occur naturally, and are easily assayed from blood, they present obvious focal molecules for therapeutic intervention and biomarker development. Recently, studies have shown that secreted proteins mediating inter-tissue signaling could be identified by ‘brute force’ surveys of all genes within RNA-sequencing measures across tissues within a population. Expanding on this intuition, we reasoned that parallel strategies could be used to understand how individual genes mediate signaling across metabolic tissues through correlative analyses of gene variation between individuals. Thus, comparison of quantitative levels of gene expression relationships between organs in a population could aid in understanding cross-organ signaling. Here, we surveyed gene-gene correlation structure across 18 metabolic tissues in 310 human individuals and 7 tissues in 103 diverse strains of mice fed a normal chow or high-fat/high-sucrose (HFHS) diet. Variation of genes such as FGF21, ADIPOQ, GCG, and IL6 showed enrichments which recapitulate experimental observations. Further, similar analyses were applied to explore both within-tissue signaling mechanisms (liver PCSK9) and genes encoding enzymes producing metabolites (adipose PNPLA2), where inter-individual correlation structure aligned with known roles for these critical metabolic pathways. Examination of sex hormone receptor correlations in mice highlighted the difference of tissue-specific variation in relationships with metabolic traits. We refer to this resource as gene-derived correlations across tissues (GD-CAT) where all tools and data are built into a web portal enabling users to perform these analyses without a single line of code (gdcat.org). This resource enables querying of any gene in any tissue to find correlated patterns of genes, cell types, pathways, and network architectures across metabolic organs.