bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunohistochemical Approach to Genetic Subtyping of Anaplastic Large Cell Lymphoma
Authors: Feldman Andrew L. , Oishi Naoki , Ketterling Rhett P. , Ansell Stephen M. , Shi Min , Dasari Surendra
Published: August 2022

Anaplastic large cell lymphoma (ALCL) can be classified genetically based on rearrangements (R) of the ALK, TP63, and/or DUSP22 genes. ALK-R defines a specific entity, ALK-positive ALCL, while DUSP22-R and TP63-R define subgroups of ALK-negative ALCLs with distinct clinicopathologic features. ALK-R and TP63-R produce oncogenic fusion proteins that can be detected by immunohistochemistry. ALK immunohistochemistry is an excellent surrogate for ALK-R and screening with p63 immunohistochemistry excludes TP63-R in two third of ALCLs. In contrast, DUSP22-R does not produce a fusion protein and its identification requires fluorescence in situ hybridization. However, DUSP22-R ALCL has a characteristic phenotype including negativity for cytotoxic markers and phospho-STAT3Y705. Recently, we also identified overexpression of the LEF1 transcription factor in DUSP22-R ALCL. Here, we sought to validate this finding and examine models for predicting DUSP22-R using immunohistochemistry for LEF1 and TIA1 or phospho-STAT3Y705. We evaluated these 3 markers in our original discovery cohort (n=45) and in an independent validation cohort (n=46) of ALCLs. The correlation between DUSP22-R and LEF1 expression replicated strongly in the validation cohort (P<0.0001). In addition, we identified and validated a strategy using LEF1 and TIA1 immunohistochemistry that predicted DUSP22-R with positive and negative predictive values of 100% after exclusion of indeterminate cases and would eliminate the need for fluorescence in situ hybridization in 65% of ALK-negative ALCLs. This approach had similar results in identifying DUSP22-R in the related condition, lymphomatoid papulosis. Together with previous data, these findings support a 4-marker immunohistochemistry algorithm using ALK, LEF1, TIA1, and p63 for genetic subtyping of ALCL.
Re-evaluation of Mirror Visual Feedback Therapy for a Systematic Evaluation/Meta-analysis of Physical Function Re-education After Stroke
Authors: Tan Xuefeng , Ding Zhimin , Guo Chenggen , Sun Pu
Published: August 2022

Objective

To re-evaluate the methodological quality and quality of evidence for a systematic evaluation/meta-analysis of the effect of mirror visual feedback therapy on physical function re-education after stroke.

Methods

Systematic evaluations/meta-analyses of mirror visual feedback therapy on physical function re-education after stroke were searched in the China Knowledge Network database, Wanfang database, Vipers database, China Biomedical Literature database, PubMed, Web of Science, and Embase using a computer, and the search time frame was up to January 2022. Methodological quality and quality of evidence ratings of the included studies were determined using the AMSTAR2 scale and GRADE classification by 2 authors.

Results

Seventeen publications were included. The evaluation with the AMSTAR2 scale showed that 1 study had an intermediate quality rating, 5 had a low-quality rating, and the remaining 11 were all very low quality. The GRADE scale showed 93 outcome indicators, of which 6 were intermediate, 23 were low grades, and the rest were very low grades, with low overall quality.

Conclusions

Mirror visual feedback therapy is efficacious for physical function re-education after stroke and promotes recovery from physical dysfunction, but the methodological quality and quality of evidence from the related systematic evaluations/meta-analyses are low.
Task-specific fear rather than general kinesiophobia assessment is associated with kinematic differences in chronic low back pain during lumbar flexion: a preliminary investigation
Authors: Imai Ryota , Imaoka Masakazu , Nakao Hidetoshi , Hida Mitsumasa , Fujii Ren , Shiba Takehiro , Nishigami Tomohiko
Published: August 2022

Introduction:

Kinematic data obtained during a movement task by individuals with chronic low back pain seem to be related to pain-related fear. General kinesiophobia assessments, such as Tampa Scale for Kinesiophobia, are often used to assess pain-related fear. However, these questionnaires could suffer from a lack of sensitivity and do not measure the fear of specific movements.

Objectives:

The purpose of this study was to investigate whether the task-specific assessment of pain-related fear exhibits a closer association with trunk kinematics during lumbar flexion compared with the general kinesiophobia in individuals with chronic low back pain.

Methods:

We assessed pain-related factors, task-specific fear, and Tampa Scale for Kinesiophobia-11 scores of 51 company employees. The lumbar angle during a lumbar flexion task was recorded by 2 wireless Axivity Ax3 accelerometers attached to the subject's spinous process (L3) and sacral spine (S2). Only task-specific fear was evaluated after the lumbar flexion task. We calculated the maximum lumbar flexion angle (°) and the peak angular velocity of lumbar flexion/return from flexion (°/s2). We conducted a hierarchical multiple linear regression analysis to determine variance explained in lumbar flexion task performance by task-specific fear after controlling for demographic, pain, and general kinesiophobia.

Results:

The results showed that task-specific fear was associated with the peak angular velocity of lumbar return from flexion (R
2 adj. = 0.36, P < 0.01) and lumbar flexion (R
2 adj. = 0.3, P = 0.01).

Discussion:

Our results suggest that clinicians should consider the potential added value of task-specific fear assessment over the sole use of conventional kinesiophobia assessment.
Follow-up blood culture in Gram-negative bacilli bacteraemia: for whom is follow-up blood culture useful?
Authors: Giannella Maddalena , Pascale Renato , Viale Pierluigi
Published: August 2022

Purpose of review

The aim of this narrative review is to examine available evidence about the diagnostic yielding of the follow-up blood cultures (FU-BCs) in patients with Gram-negative bloodstream infection (GN-BSI), the predictors of persistent GN-BSI, and the impact of the performance of FU-BCs on patient management and clinical outcome.

Recent findings

The rate of persistent GN-BSI varies from 2.6% to 38.5%, with higher percentages in studies where FU-BCs were obtained from selected patients. Risk factors for persistent GN-BSI were analysed and prediction tools were proposed to guide physicians in the selection of patients. The impact of FU-BCs on patient management is still controversial as several authors have shown that this practice was associated with prolonged treatment duration and longer hospital stay. However, when adjusted for indication and survival bias, the performance of FU-BCs was a strong predictor of survival in large cohorts of hospitalized patients with GN-BSI. Favourable outcome seemed to be associated with higher rate of source control in GN-BSI patients managed with FU-BCs.

The practice of FU-BCs in patients with GN-BSI should be individualised balancing cost/benefit ratio. The use of risk scores could be useful in selecting patients for whom FU-BCs are appropriate.
Re-Aiming Equity Evaluation in Clinical Decision Support
Authors: Ingraham Nicholas E. , Jones Emma K. , King Samantha , Dries James , Phillips Michael , Loftus Tyler , Evans Heather L. , Melton Genevieve B. , Tignanelli Christopher J.
Published: August 2022

Objective:

We critically evaluated the surgical literature to explore the prevalence and describe how equity assessments occur when using clinical decision support systems.

Background:

Clinical decision support (CDS) systems are increasingly used to facilitate surgical care delivery. Despite formal recommendations to do so, equity evaluations are not routinely performed on CDS systems and underrepresented populations are at risk of harm and further health disparities. We explored surgical literature to determine frequency and rigor of CDS equity assessments and offer recommendations to improve CDS equity by appending existing frameworks.

Methods:

We performed a scoping review up to Augus 25, 2021 using PubMed and Google Scholar for the following search terms: clinical decision support, implementation, RE-AIM, Proctor, Proctor’s framework, equity, trauma, surgery, surgical. We identified 1415 citations and 229 abstracts met criteria for review. A total of 84 underwent full review after 145 were excluded if they did not assess outcomes of an electronic CDS tool or have a surgical use case.

Results:

Only 6% (5/84) of surgical CDS systems reported equity analyses, suggesting that current methods for optimizing equity in surgical CDS are inadequate. We propose revising the RE-AIM framework to include an Equity element (RE2-AIM) specifying that CDS foundational analyses and algorithms are performed or trained on balanced datasets with sociodemographic characteristics that accurately represent the CDS target population and are assessed by sensitivity analyses focused on vulnerable subpopulations.

Conclusion:

Current surgical CDS literature reports little with respect to equity. Revising the RE-AIM framework to include an Equity element (RE2-AIM) promotes the development and implementation of CDS systems that, at minimum, do not worsen healthcare disparities and possibly improve their generalizability.
Update on dermatomyositis
Authors: Tanboon Jantima , Nishino Ichizo
Published: August 2022

Purpose of review

This review summarizes and comments on current knowledge in dermatomyositis.

Recent findings

The 2018 European Neuromuscular Centre classification of dermatomyositis has been challenging by the discovery of clinicopathological features associated with dermatomyositis-specific antibody (DMSA) that were not incorporated in the original criteria. These features include but may not be limited to the presence of perifascicular necrosis in anti-Mi-2 dermatomyositis; presence of diffuse nonperifascicular sarcoplasmic myxovirus resistance protein A expression in anti-MDA5 dermatomyositis; and dermatomyositis sine dermatitis in anti-NXP-2 dermatomyositis. Variations and subclassifications within the same DMSA subtypes are observed: anti-MDA5 dermatomyositis is clinically subcategorized into good, intermediate, and poor prognostic subgroups; concurrent anti-CCAR1 and anti-TIF1-γ positivity identify anti-TIF1-γ-positive patient with a lower risk for cancer-associated myositis. Owing to distinct IFN1-signaling pathway activation in dermatomyositis, JAK-STAT inhibitor – the pathway-targeted therapy, have been studied with promising results in refractory dermatomyositis and some new-onset dermatomyositis. In addition, the potential serum biomarkers for IFN1 pathway activation are being investigated for their performance in monitoring the disease activity and the efficacy of the treatment.

DMSA, evidence of prominent IFN1 pathway activation, and risk/severity-associated biomarkers would likely play major roles in future dermatomyositis classification, disease monitoring, and treatment decision.
Clinical studies in amyotrophic lateral sclerosis
Authors: Dorst Johannes , Genge Angela
Published: August 2022

Purpose of review

The purpose of this review is to discuss the most important recent clinical studies in amyotrophic lateral sclerosis (ALS), including their impact on clinical practice, their methodology, and open questions to be addressed in the future.

Recent findings

This article focuses on studies, which provided either a positive primary endpoint or positive post hoc analysis, including edaravone, sodium phenylbutyrate–taurursodiol, rasagiline, tofersen, and high-caloric, fat-rich nutrition. It also covers recent developments in the design of clinical ALS studies with regard to inclusion criteria, stratification factors, and outcome parameters.

Recent clinical studies have indicated various substances to be considered for treatment of ALS. Edaravone has been approved by the US Food and Drug Association (FDA) but not by the European Medicines Agency (EMA), and further studies testing oral formulations are currently conducted. A follow-up study with sodium phenylbutyrate–taurursodiol is ongoing, while follow-up studies for rasagiline and high-caloric, fat-rich nutrition are planned. A phase III study with tofersen was negative but nevertheless yielded promising results. Important developments regarding the design of clinical ALS studies include the implementation of neurofilament light chain (NfL) levels as a standard outcome parameter and the consideration of progression rate for therapeutic response and stratification.
Crystal structure, Hirshfeld surface analysis and DFT calculations of 7-bromo-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Authors: Tojiboev Akmaljon , Elmuradov Burkhon , Kattaev Nuritdin , Abdurazakov Asqar , Nasrullayev Azizbek , Tashkhodjaev Bakhodir
Published: August 2022

The molecular structure of the title compound, C11H9BrN2O, is almost planar. The benzene and pyrimidine rings are essentially coplanar, with r.m.s. deviations of 0.0130 Å, and the largest displacement is for the flap atom of the dihydropyrrole moiety [0.154 (7) Å]. Hirshfeld surface analyses revealed that the crystal packing is dominated by H...H, Br...H/H...Br and O...H/H...O interactions, and Br...Br interactions in the crystal structure are also observed. Theoretical calculations using density functional theory (DFT) with the B3LYP functional basis set gave numerical parameters for the frontier molecular orbitals.
When to choose ranked area integrals versus integrated gradient for explainable artificial intelligence – a comparison of algorithms
Authors: Singh Vinay , Konovalova Iuliia , Kar Arpan Kumar
Published: August 2022

Purpose

Explainable artificial intelligence (XAI) has importance in several industrial applications. The study aims to provide a comparison of two important methods used for explainable AI algorithms.

Design/methodology/approach

In this study multiple criteria has been used to compare between explainable Ranked Area Integrals (xRAI) and integrated gradient (IG) methods for the explainability of AI algorithms, based on a multimethod phase-wise analysis research design.

Findings

The theoretical part includes the comparison of frameworks of two methods. In contrast, the methods have been compared across five dimensions like functional, operational, usability, safety and validation, from a practical point of view.

Research limitations/implications

A comparison has been made by combining criteria from theoretical and practical points of view, which demonstrates tradeoffs in terms of choices for the user.

Originality/value

Our results show that the xRAI method performs better from a theoretical point of view. However, the IG method shows a good result with both model accuracy and prediction quality.
Sarvaay Solutions – creating value innovation for farmers
Authors: Ghura Amarpreet Singh , Damani Bharat
Published: August 2022

Learning outcomes

The case demonstrates the use of strategic management tools such as pros and cons analysis, SWOT analysis, strategy canvas, the four-action framework and the eliminate–reduce–raise–create grid to create a Blue Ocean.Through a discussion of the case, students will be able to:▪ conduct pros and cons analysis to objectively understand a situation;▪ conduct SWOT analysis to understand the internal and external ecosystem;▪ understand non-customers and paths to reach them;▪ demonstrate the role of strategy canvas and the four-action framework in designing a new offering; and▪ explain how to create a Blue Ocean market space, by implementing the concept of value innovation.

Case overview/synopsis

This case describes a situation in which Dr Vishal Sardeshpande (Sardeshpande), a first-generation entrepreneur in the agro and food processing industry, started Sarvaay Solutions to provide technological solutions for the sector, especially for the small/medium-sized farmer. Such farmers did not have access to technology and the markets to create value addition on their farm produce, and hence were at the mercy of the middlemen or the large farmers. After years of experimentation from 2006 till 2018, Sardeshpande made a resource-efficient jaggery manufacturing process (REJMP) in Pune to enable and empower the farmer to produce quality jaggery using their own sugarcane, which otherwise was sold to the middlemen. Sardeshpande knew the industry and was aware of the challenges faced by the farmers, traditional jaggery producers and cooperative farming bodies. In June 2022, while sitting in his house, Sardeshpande was struck with an idea that the key to success of REJMP is to empower farmers or traditional jaggery producers or cooperative farming bodies to create value from agriculture produce and wondered the way forward. The purpose of this case is to provide an opportunity for the participants to use management tools such as strategy canvas, four-action framework, Pros and Cons analysis and SWOT analysis to understand noncustomers and paths to reach them and understand new industry creation. Participants need to take into consideration the data given in the case and make realistic assumptions to understand how new industries are created.

Complexity academic level

The case engages the participants in deciding a suitable course of action for Sardeshpande to decide the Blue Ocean strategy. It helps them to delineate the challenges faced by an entrepreneur to select a route for the new market space.The case is ideal for undergraduate, postgraduate or executive education students and can be used in the following courses of a business management, agri business management or entrepreneurship programs:▪ creating new industries;▪ Blue Ocean strategy; and▪ strategic management.

Supplementary material

Teaching notes are available for educators only.

Subject code

CSS 3: Entrepreneurship.
The political game of innovation: evidence from the ride-hailing service industry
Authors: Cheah Chee Wei , Koay Kian Yeik
Published: August 2022

Purpose

Underpinned by the legitimacy perspective, this study explores how ride-hailing services are legitimized through resource exchange among the industry players. The authors explore the types of legitimacy involved in the legitimation process. The authors also examine the political games being played by the actors to attain legitimacy.

Design/methodology/approach

This qualitative study involves thirty-one stakeholders/interviewees from emerging Asia. The interview data are supported by online documents and observations.

Findings

Thematic analysis shows that the industry players collaborate to achieve political, market, alliance, social, and investment legitimacy. The collaborations also legitimize industry players' existence through an eclectic mix of the numerous stakeholders' actions. This study shows how Dacin's proposed four types of legitimacy are coexisting and interconnected. It also highlights the neglected political legitimacy.

Originality/value

The findings guide the policymakers and ride-hailing operators experiencing competing requests to legitimize sustainable ride-hailing service development in urban cities.
Assessment of digital library design guidelines to support blind and visually impaired users: a study of key stakeholders’ perspectives
Authors: Xie Iris , Babu Rakesh , Wang Shengang , Lee Hyun Seung , Lee Tae Hee
Published: August 2022

Purpose

This study aims to investigate the perceptional differences of key stakeholders in assessing the Digital Library Accessibility and Usability Guidelines (DLAUG), in which design information is created and organized by types of help-seeking situations, to support blind and visually impaired (BVI) users. The stakeholders consist of BVI users, digital library (DL) developers and scholars/experts. The focus is on the identification of types of situations in which BVI users and developers show significant perception differences of DLAUG’s relevance, clarity and usefulness than the other two groups, respectively, and the associated reasons.

Design/methodology/approach

An in-depth survey was conducted to examine the perceptions of 150 participants representing three groups of key DL stakeholders: BVI users, DL developers and scholars/experts. Both qualitative and quantitative analyses were applied.

Findings

The results show that BVI users and developers had significant perception differences of the relevance, clarity and usefulness of the DLAUG than the other two groups held on five situations, mainly because they played distinct roles in the development of DLs with differing goals and expectations for the DL design guidelines.

Originality/value

This is the first study that considers different DL stakeholders to assess DL guidelines to support BVI users.
The development of teachers' knowledge in a lesson study
Authors: Da Ponte João Pedro , Quaresma Marisa , Mata-Pereira Joana
Published: August 2022

Purpose

This paper seeks to understand how teachers' mathematical knowledge for teaching (MKT) is developed during a lesson study regarded as a professional development process that places particular emphasis on teachers' knowledge of tasks, representations and students' learning.

Design/methodology/approach

This study is based on the networking of two theories, namely the Interconnected Model of Teacher Professional Growth (IMTPG) and MKT. The methodology is qualitative and interpretative. The participants are three primary school teachers and team members involved in a lesson study. Data collection was conducted by means of participant observation, with audio recordings of the sessions and a final individual interview.

Findings

The participant teachers developed their knowledge of tasks and representations, which are essential elements of content and teaching knowledge, as well as knowledge of the curriculum, content and students. Additionally, they developed specialized knowledge of mathematics, the meaning of fraction as a measure and its representation on the number line. This development arose from activities conducted in the Domain of Practice, in many cases prompted by the External Domain, and was particularly important when these activities gave rise to unforeseen consequences. Connections among the various domains were established through enactment and reflection processes.

Originality/value

The study shows how the networking of two different theories, in this case the IMTPG and MKT, may enhance further understanding of educational phenomena. This networking involved the coordination of these two theories, which were superimposed in the Group Domain.
Topics and changing characteristics of knowledge organization research in the 21st century: a content analysis
Authors: Si Li , He Yi , Liu Li
Published: August 2022

Purpose

Knowledge organization (KO) has been advancing at a progressively rapid pace under the influence of information technology. This study aims to explore the topics, characteristics, and trends of KO research in the 21st century.

Design/methodology/approach

The full text of 4,360 KO-related articles published from 2000 to 2021 is collected. Through content analysis, this study identifies the topics, research methods, and application areas of each article, and the statistics are presented through a series of visualizations.

Findings

In total, 13 main topics, 105 sub-topics, 16 research methods, and 57 application areas are identified. Notably, classification has always been an important topic, while linked data, automated techniques, and ontology have become popular topics recently. Significant changing features have also occurred. The versatile use of research methods has increased, with empirical research becoming the mainstream. Application areas show a trend of refinement from subject areas to specific scenarios. Construction techniques present a combination of automated techniques, crowdsourcing, and experts.

Originality/value

KO has evolved and diversified due to technological developments. This study is the first to focus on the continuous changing features over an extended, 21-year period, as opposed to sampling a few years. It also provides clues and insights for researchers and practitioners interested in KO to understand how it has changed in the Semantic Web and big data context.
Entrepreneurship and institutional uncertainty
Authors: D’Andrea Fernando Antonio Monteiro Christoph
Published: August 2022

Purpose

The study aims to demonstrate how different arrangements and characteristics of institutions can generate or mitigate uncertainty thereby facilitating or hampering the possibilities of entrepreneurial action.

Design/methodology/approach

This is a conceptual paper that advances the theoretical understanding of the relationship between entrepreneurial uncertainty and the different institutional levels, their characteristics and their interplay.

Findings

Entrepreneurial uncertainty also comes from the institutional environment and this has direct impact on the propensity to take action. The characteristics of the different institutional levels, in specific, their quality, stability, alignment and the burden imposed by L2 impact in the emergence of entrepreneurial uncertainty.

Research limitations/implications

This is a conceptual paper that makes a number of theoretical suggestions which need to be further analyzed by empirical work.

Practical implications

The findings suggest that different institutional levels need to be dealt with differently by research studies and institutional agents, including policy makers. Among others, the findings also suggest that stability is key to entrepreneurship and that the benefits of high quality regulation can be undermined by its excessive burden, reducing entrepreneurial action and harming development.

Social implications

Institutional actors should provide stability and allow for the improvement of the environment overall. Specifically, policy makers should aim at good quality regulation that is valid across the board, that provides stability and gives room for improvement of the institutions. Policy makers should refrain from trying to foster specific industries; they should instead provide a leveled playing field without trying to direct the entrepreneurial efforts towards an industry or geographic region and without being overly demeaning.

Originality/value

This research breaks new ground. It unites ideas from entrepreneurship and institutions suggesting a novel, much more nuanced approach to their interplay. The results can be used by scholars in the fields of entrepreneurship, institutions and economic development. They also have the potential to help to educate policy makers in their quest to improve the context for entrepreneurs.
Transforming healthcare service environments: a sensory-based approach
Authors: Yap Sheau Fen (Crystal) , Phillips Megan , Hwang Euejung , Xu Yingzi
Published: August 2022

Purpose

Healthcare service is a process that comprises a series of touchpoints underlying the key facets of service delivery, collectively shaping the users' (i.e. patients, hospital staff, and visitors) experiences. Departing from most sensory studies dedicated to understanding the retail environment and hedonic service, this study focuses on how sensory knowledge can contribute to understanding the sensory-based experiences of hospital users and their interactions with healthcare services at multiple touchpoints.

Design/methodology/approach

This study employs a multi-method approach comprising two studies involving semi-structured interviews and a qualitative online survey of past patients.

Findings

Drawing upon the user-centered theory, the authors (1) consulted healthcare experts on hospital service touchpoints and standards around medical protocol; (2) explored users' needs, experiences, expectations, and evaluations of healthcare services; and (3) identified the issues and challenges faced by healthcare service users at various service touchpoints. Based on these insights, the authors proposed sensory tactics across healthcare service touchpoints that promote the well-being of major hospital users.

Research limitations/implications

The proposed sensory tactics require follow-up empirical evidence. Future research could adopt robust methodological designs on healthcare environmental interventions and progress with a transdisciplinary approach to advance this research area.

Practical implications

The authors' experience-based framework forms the basis of a valuable toolkit for healthcare service management.

Originality/value

This study advances services literature by integrating sense-based marketing knowledge with healthcare service research to understand the dynamic and interactive relationship between hospital users and the environment.
Leader humility and inter-firm collaboration: the moderating role of firm status and environmental uncertainty
Authors: Zhou Jieyu , Bu Mengmeng , Jia Liangding
Published: August 2022

Purpose

The purpose of this paper is to investigate how CEO humility influences inter-firm collaboration (IFC) and the moderating roles of firm status (a firm's relative position in a social order) and environmental uncertainty on such an effect.

Design/methodology/approach

As the firms were nested in township clusters, the theoretical model was tested using hierarchical linear modeling to analyze a multisource and multilevel onsite survey from 254 firms in Chinese township clusters. CEO humility was measured using an 18-item scale reported by both the human resource managers and the financial managers. Besides using CEO self-reported ratings as the measurement of IFC, this study employed additional measurements to further validate the findings, including the IFC reported by the administrative managers and two alternative measures for IFC reported by both CEO and the administrative managers of each firm.

Findings

This study found that CEO humility is positively related to IFC (H1), and that this association is marginally more salient when firms have high status (H2) but less salient when firms face a high level of environmental uncertainty (H3).

Practical implications

Findings suggest that firms with humble CEOs may benefit from better inter-firm collaborative relationships, especially when firms have high status (i.e. possess many well-known trademarks), but not when they are in an uncertain environment.

Originality/value

Previous humility studies focused on the influence of leader humility on individual and team outcomes, but little attention has been paid to organizational outcomes. This research extends the implications of leader humility to inter-firm relationships. Moreover, this paper explores the boundary conditions of the influence of CEO humility, thus advancing the contextual understanding of leader humility.
Sustainable development through sustainable entrepreneurship and innovation: a single-case approach
Authors: Vig Shinu
Published: August 2022

Purpose

This paper aims to understand how a sustainable entrepreneur through his/her sustainable innovation can implement the three pillars of sustainable development, i.e. economic, social and environmental pillars, and how an entrepreneurial opportunity can be sought in environmental problems to develop a new product.

Design/methodology/approach

A qualitative research approach using a single-case study design has been adopted. It discusses the case of an Indian sustainable entrepreneur working for the cause of reducing plastic pollution in India and providing employment to rural women from economically weaker backgrounds. Data was primarily collected through semi-structured interviews, which were analyzed through thematic analysis.

Findings

The paper shows how an entrepreneur through entrepreneurial opportunity discovery and sustainable innovation contributes toward sustainable development.

Practical implications

This study highlights the need for institutional support by governments for a wide spectrum of sustainable enterprises as they can help the governments in achieving sustainable development goals at local levels. It will also act as a representative example for the entrepreneurs about how one can covert an environmental problem into an opportunity, through sustainable innovation.

Originality/value

The originality of the study lies in the presentation of an innovative idea developed by the entrepreneur for addressing the problem of plastic waste. The case used here demonstrates that sustainable entrepreneurship, through sustainable innovation, can deal with multiple economic, social and environmental issues.
The impact of Covid-19 on organisational commitment with mediating role of satisfaction among the Iraqi auditors
Authors: Lari Dashtbayaz Mahmoud , Salehi Mahdi , Mozan Sadeq
Published: August 2022

Purpose

The study seeks to examine the effect of the Covid-19 on organisational commitment with the mediating role of job satisfaction of Iraqi auditors to determine the impact the Corona has on the organisational commitment of Iraqi auditors with the mediating role of job satisfaction.

Design/methodology/approach

The study's statistical population consists of those auditors working in the auditing organisations and private sector auditing institutions in Iraq. The number of respondents was 1,500 and 305 questionnaires were collected and analysed using Cochran's formula. Data were collected using the Covid1-19 questionnaire developed by the researcher, Minnesota Life Satisfaction Questionnaire (1967) and Allen and Meyer (1990) Organisational Commitment Questionnaire. In this study, the components of individual fear, collective fear and the transition from a feeling of security to insecurity with 29 questions for the impact of Covid-19 and job satisfaction components derived from the Minnesota Model, which includes six components (payment system, nature of job, progress opportunities, organisational atmosphere, leadership style and physical condition) is based on 19 questions. The components of organisational commitment are based on three types of emotional commitment, continuance commitment and normative commitment with 24 questions. Structural equation modelling using Smart-PLS software was used to analyse the data.

Findings

The results showed that the Covid-19 effect variable was not significant on organisational commitment but was significant considering the mediating role of job satisfaction.

Originality/value

The paper has covered a very interesting topic nowadays and the results may give great insight to auditors in a challenging condition due to COVID 19.
Use of strontium isotope ratios in geolocation of Guatemalan population: Potential role in identification of remains
Authors: Austin Ryan , Fowler Gillian , Cooper Jonathan J. , Perez Tanchez Marco , Croxton Ruth , Evans Jane , Thompson David F.
Published: August 2022

Within post‐conflict communities, attempts to identify and repatriate unidentified and missing individuals poses a difficult task. As current forensic strategies commonly lack the capacity to provide region of origin assessments, forensic anthropologists/investigators are often unable to identify sources of DNA for kinship analysis. Using Thermal Ionization Mass Spectrometry (TIMS), hair samples from 10 volunteers were used to assess the variation in strontium isotope ratios (87Sr/86Sr) between extant people in Guatemala City and Coban; with a leach (external) and digest (dietary) signal analyzed for each sample. A two‐way anova demonstrated that the difference between 87Sr/86Sr of Guatemala City and Coban was statistically significant (F [1, 16] = 259.839, p < 0.05), with no statistically significant differences observed between leach and digest 87Sr/86Sr (F [1,16] = 4.319, p = 0.054). Overall, individuals from Coban demonstrate 87Sr/86Sr comparable to previously recorded baseline values, demonstrating a minimal change in diet which is reflected in associated surveys. Volunteers from Guatemala City, however, show a marked shift in 87Sr/86Sr away from predicted values highlighting the potential influence of imported goods. The results here highlight the applicability of 87Sr/86Sr in hair to serve as a potential tool to support the identification of unknown individuals in Guatemala in a forensic context.
“Forest medicines,” Kinship Alliances, and Equivocations in the Contemporary Dialogues between Santo Daime and the Yawanawá
Authors: Platero Lígia Duque , de Rose Isabel Santana
Published: August 2022

In this paper, we describe the spiritual and kinship alliances between heads of an urban Santo Daime church from Rio de Janeiro and some leaders of the Yawanawá people from the Amazonian region. We suggest that these alliances involve exchanges and dialogical relationships that hold different meanings for the diverse social actors that take part in them. Further, we argue that equivocation and functional misunderstandings have an important role in these multidirectional dialogues. Based on this case study, we approach the Yawanawá strategies for capturing otherness, and the insertion of the daimistas in the indigenous sociality networks. We focus especially on the Yawanawá mode of producing kin by capturing non‐indigenous people and their participation in exchange networks that encompass multiple regimes of value. From the daimista point of view, we describe these relationships using the native category of “eclecticism.” We suggest that the daimistas attempt to translate the Yawanawá shamanic knowledge and the consumption of the “forest medicines,” experiencing the performance of “becoming indigenous.”
The relationship between habitual water intake and dry eye disease
Authors: Nguyen Long , Magno Morten Schjerven , Utheim Tor P. , Jansonius Nomdo M. , Hammond Christopher J. , Vehof Jelle
Published: August 2022

Purpose

The purpose of this study is to test the hypothesis that greater habitual water intake is associated with lower risk of dry eye disease (DED).

Methods

We included 51 551 participants from the population‐based Lifelines cohort (mean age = 51.2 years) in this cross‐sectional association study. DED was assessed using the Women's Health Study (WHS) dry eye questionnaire. Water intake was calculated from food frequency questionnaires. Logistic regressions were used to analyse the relationship between DED and water intake or 24‐h urine volume, corrected for age, sex, body mass index, physical activity, smoking status, education, income, 48 comorbidities, and 15 medication groups.

The main outcome measure was WHS‐defined DED. Highly symptomatic dry eye and clinical diagnosis of DED were secondary outcomes.

Results

In total, 9.1% of the population had WHS‐defined DED. Higher water intake was associated with increased prevalence of WHS‐defined DED (OR: 1.011 per 100 ml/day, 95% CI: 1.004–1.017, p = 0.003). After excluding those with a clinical diagnosis, greater water intake was still tied to increased risk of having DED symptoms (OR: 1.010 per 100 ml/day, 95% CI: 1.006–1.015, p < 0.001). Higher 24‐h urine volumes were also associated with higher risk of WHS‐defined DED (OR: 1.010 per 100 ml/day, 95% CI: 1.005–1.015, p < 0.001).

Conclusions

In this large, population‐based study, higher water intake was not tied to reduced risk of DED. Rather, it was associated with a modest increased risk of DED. Interventional studies are needed to fully understand the effect of water intake on DED, but this study found no evidence that greater water intake is beneficial for DED.
Effect of calcitriol treatment on arterial stiffness in people with type 2 diabetes and stage 3 chronic kidney disease
Authors: Karalliedde Janaka , Fountoulakis Nikolaos , Corcillo Antonella , Maltese Giuseppe , Flaquer Maria , Stathi Dimitra , Mangelis Anastasios , Panagiotou Angeliki , Ayis Salma , Thomas Stephen , Gnudi Luigi
Published: August 2022

Aims

Active vitamin D deficiency is associated with increased aortic‐pulse wave velocity (Ao‐PWV) in people with type 2 diabetes (T2DM) and chronic kidney disease (CKD). There are no randomised controlled trials investigating the effect of active vitamin D treatment on Ao‐PWV in people with T2DM and CKD.

Methods

A 48‐week duration single‐centre randomised double‐blind parallel‐group trial examined the impact of oral 1,25 dihydroxyvitamin D (calcitriol 0.25 mcg OD) as compared to placebo on a primary endpoint of Ao‐PWV. People with T2DM and stable stage 3 CKD with intact parathyroid hormone (iPTH) level >30 pg/mL were eligible.

Results

In total, 127 (70% male) people were randomised (calcitriol n = 64 or placebo n = 63). There was no change in Ao‐PWV observed, mean ± standard deviation (SD), in the calcitriol group of 11.79 (±2.5) to 12.08 (3.0) m/s as compared to 10.90 (±2.4) to 11.39 (±2.6) m/s with placebo. The between‐treatment group adjusted mean (95% confidence interval [(CI]] change was 0.23 (−0.58 to 1.05) m/s, P = .57. No effect of calcitriol was observed on central arterial pressures, albuminuria, serum calcium or phosphate levels. However, iPTH fell with calcitriol treatment (mean [95% CI] between‐group difference of −27.8 (−42.3 to −13.2) pg/mL, P < .001.

Conclusion

In T2DM and stage 3 CKD, calcitriol as compared to placebo does not improve Ao‐PWV or other markers of arterial stiffness. Our study does not provide evidence for the use of active vitamin D for improving arterial stiffness in T2DM with stage 3 CKD.
A comprehensive pharmacogenomic study indicates roles for SLCO1B1, ABCG2 and SLCO2B1 in rosuvastatin pharmacokinetics
Authors: Lehtisalo Minna , Taskinen Suvi , Tarkiainen E. Katriina , Neuvonen Mikko , Viinamäki Jenni , Paile‐Hyvärinen Maria , Lilius Tuomas O. , Tapaninen Tuija , Backman Janne T. , Tornio Aleksi , Niemi Mikko
Published: August 2022

Aims

The aim was to comprehensively investigate the effects of genetic variability on the pharmacokinetics of rosuvastatin.

Methods

We conducted a genome‐wide association study and candidate gene analyses of single dose rosuvastatin pharmacokinetics in a prospective study (n = 159) and a cohort of previously published studies (n = 88).

Results

In a genome‐wide association meta‐analysis of the prospective study and the cohort of previously published studies, the SLCO1B1 c.521 T > C (rs4149056) single nucleotide variation (SNV) associated with increased area under the plasma concentration–time curve (AUC) and peak plasma concentration of rosuvastatin (P = 1.8 × 10−12 and P = 3.2 × 10−15). The candidate gene analysis suggested that the ABCG2 c.421C > A (rs2231142) SNV associates with increased rosuvastatin AUC (P = .0079), while the SLCO1B1 c.388A > G (rs2306283) and SLCO2B1 c.1457C > T (rs2306168) SNVs associate with decreased rosuvastatin AUC (P = .0041 and P = .0076). Based on SLCO1B1 genotypes, we stratified the participants into poor, decreased, normal, increased and highly increased organic anion transporting polypeptide (OATP) 1B1 function groups. The OATP1B1 poor function phenotype associated with 2.1‐fold (90% confidence interval 1.6–2.8, P = 4.69 × 10−5) increased AUC of rosuvastatin, whereas the OATP1B1 highly increased function phenotype associated with a 44% (16–62%; P = .019) decreased rosuvastatin AUC. The ABCG2 c.421A/A genotype associated with 2.2‐fold (1.5–3.0; P = 2.6 × 10−4) increased AUC of rosuvastatin. The SLCO2B1 c.1457C/T genotype associated with 28% decreased rosuvastatin AUC (11–42%; P = .01).

Conclusion

These data suggest roles for SLCO1B1, ABCG2 and SLCO2B1 in rosuvastatin pharmacokinetics. Poor SLCO1B1 or ABCG2 function genotypes may increase the risk of rosuvastatin‐induced myotoxicity. Reduced doses of rosuvastatin are advisable for patients with these genotypes.
Reducing patient delay in acute coronary syndrome: Randomized controlled trial testing effect of behaviour change intervention on intentions to seek help
Authors: Farquharson Barbara , Johnston Marie , Williams Brian , Smith Karen , Dombrowski Stephan , Jones Claire , Treweek Shaun , Dougall Nadine , Grindle Mark , Savinc Jan , Abyhankar Purva
Published: August 2022

Objectives

The aim of this study was to evaluate the efficacy of a behaviour change intervention to reduce patient delay with symptoms of acute coronary syndrome.

Design

A 3‐arm web‐based, parallel randomized controlled trial.

Methods

The intervention comprised 12 behaviour change techniques (BCTs) embedded in a text‐only or text+visual narrative (the techniques were systematically identified through systematic review and a consensus exercise). Between February and November 2017, n = 145 people who had recently experienced acute coronary syndrome were randomly allocated to intervention (‘text+visual’ or ‘text‐only’) or control. Intentions to phone an ambulance immediately for acute coronary syndrome symptoms were assessed before and after the intervention using symptom scenarios, and the change in intention was compared across the three groups.

Results

Significant increases in intention to phone an ambulance immediately for ACS symptoms were seen following the ‘text+visual’ intervention but not following ‘text‐only’ or control. However, the study was underpowered to detect any significant changes in intention between the 3 groups. There were no unintended effects on intentions for non‐urgent symptoms.

Conclusions

A ‘text+visual’ BCT‐based intervention may significantly increase intention to phone an ambulance with symptoms of ACS. Further testing of the effect of the intervention on actual behaviour is required.
Preoperative MRI presentations of Herlyn–Werner–Wunderlich syndrome
Authors: Zhang Heng , Zheng Ying , Ning Gang , Fu Chuan , Bao Li
Published: August 2022

Herlyn–Werner–Wunderlich (HWW) syndrome is a rare complex female urogenital anomaly, with diverse anatomical presentations. Due to obstruction, most patients with HWW syndrome need to be addressed surgically. The treatment strategy should be tailored to the different anatomical variants of each patient. Therefore, a detailed and comprehensive preoperative evaluation is needed. In this review, we describe the embryology and clinical manifestations of HWW syndrome and discuss and illustrate its diverse preoperative magnetic resonance imaging presentations to guide clinical treatment.
Prescribed burning has limited effects on the population dynamics of rare plants
Authors: Novak Logan , Scholl Joshua P. , Kiefer Gretel , Iler Amy M.
Published: August 2022

Rare species serve important ecosystem functions, including community resilience to global change. Yet rare species are disappearing globally because of anthropogenic activities such as fire suppression. Prescribed burning is a widespread management approach that can reduce invasive plant presence, recycle nutrients, and restore species diversity. However, the effects of prescribed burning on rare plants are not well understood. We analyzed the population dynamics of 67 rare, native plant species in response to prescribed burning using the Chicago botanic garden's Plants of Concern dataset. This dataset includes rare plant populations concentrated in the northeast part of Illinois, and a few populations in Indiana and Wisconsin, United States. We evaluated the effects of burning by comparing the percent change in population size in the short‐term (1–2 years) and long‐term (3–4 years) after prescribed burning, to the percent change in population size not following burns. In a global model with all species, we did not detect the effects of burning on percent change in population size. In species‐level analyses, we detected burn effects for most species for which we had the statistical power to detect possible burn responses, although the direction of their responses was mixed. Five species responded consistently between short‐ and long‐term datasets, and four species had mixed responses, with most responding positively over the short‐term and negatively over the long‐term. We complemented this analysis with a literature review of fire responses for available species. Our literature review revealed more responses to burning than what we found from our analyses; however, most of this evidence does not compare burned and unburned populations directly and should be treated cautiously. Through community science monitoring efforts, we were able to compile one of the largest studies of burn effects on rare plants to date, but continued monitoring is necessary to fully evaluate how prescribed burning impacts rare plant species.