bluuebunny/crossref_metadata_2025 huggingface dataset:
Iron deficiency anemia in relation to pinch strength and hand dexterity in preschool children: a cross-sectional study
Authors: Amer Fatma Essam , Mamdouh Khaled Ahmed , Hassan Tamer Hasan Moustafa , Abd-El-Nabie Walaa A. , Eltalawy Hoda
Published: June 2024

Background

Iron deficiency anemia (IDA) constitutes a considerable nutritional problem in Egyptian preschool children. Moreover, IDA limits physical activity performance and interferes with children's development. Accordingly, we aim to investigate the correlation between IDA and hand dexterity and pinch grip strength in preschool children.

Results

This observational cross-sectional study encompassed the participation of 87 children, comprising both genders, with an age range of 5–6 years. The cohort was initially stratified into three distinct groups: Group A comprised 36 non-anemic children, group B included 25 children with mild iron-deficiency anemia (IDA), and group C consisted of 26 children with moderate IDA. After group delineation, comprehensive laboratory analyses were performed on all participants to assess for IDA, involving a thorough examination of their complete blood picture, hemoglobin (Hb) levels, serum iron levels, and serum ferritin levels. The evaluative metrics employed in this study encompassed the Bruininks-Oseretsky Test of Motor Proficiency-Second Edition (BOT-2) and the Baseline Mechanical Pinch Gauge. These instruments were utilized to assess manual dexterity and pinch strength, specifically tip-to-tip and tripod strength. This investigation revealed a positive correlation between Hb, serum iron, and serum ferritin levels with both manual dexterity and pinch strength across all three groups.

Conclusion

This study highlights that IDA negatively affects hand dexterity and pinch grip strength in preschool children. Managing IDA early is crucial for improving their physical performance and overall development.
Targeting glioma stem cells with thyroid hormone suppression: Phase 1/2 trial of methimazole in patients with progressive grade 4 gliomas.
Authors: Peereboom David M. , Ponti Andras , Yang Kailin , Silver Daniel , Hufsey Rachel , El Hage Lea , Li Hong , Cordova Christine , Dhawan Andrew , Lobbous Mina , Malkin Mark Gordon , Stevens Glen , Torres-Trejo Alejandro , Angelov Lilyana , Barnett Gene , Grabowski Matthew , Mohammadi Alireza , Soni Pranay , Lathia Justin , Hine Christopher
Published: June 2024

2044

Background: Gaseous hydrogen sulfide (H2S), a by-product of cysteine metabolism, inhibits the growth of glioblastoma (GBM) cells and impairs GBM progression in mice. Likewise, H2S generation and sulfhydration are decreased in human GBM specimens as compared to non-tumor controls. Thus, boosting H2S production is a novel strategy for GBM treatment. Suppression of thyroid hormone (TH) signaling increases endogenous production of H2S. We hypothesize that methimazole-induced hypothyroidism will enhance the efficacy of chemotherapy in WHO grade 4 gliomas by boosting H2S production capacity (HPC) within the tumor. The goal of this trial is to provide proof of concept that suppression of TH signaling, via methimazole and subsequent augmentation of H2S synthesis and signaling, is feasible in patients with WHO grade 4 gliomas (G4G). Methods: This modified phase 1/2 study evaluates the safety and efficacy of methimazole + chemotherapy with pharmacodynamic correlates in patients with progressive G4G. The main objective is a 10% increase in HPC and a 1.5-fold increase in peripheral blood sulfhydration signaling (SS). Patients who are planned for a clinically-indicated resection receive pre-op (5-7 days) and post-op methimazole with the addition of investigator’s choice of chemotherapy 1 month after starting post op methimazole. Patients receive methimazole + chemotherapy until progression. Resected tumor will be assayed for HPC and for proteins relevant to H2S production. Peripheral blood lead-acetate assays for HPC and SS are obtained at baseline, pre-op, intra-op, post-op, before the addition of chemotherapy, and before each cycle of methimazole + chemo. Key eligibility criteria: progressive G4G for whom a clinically-indicated resection is planned, and normal thyroid function with no history of thyroid disease. Patients may have had unlimited prior regimens including bevacizumab. Results: To date six patients (4 male) ages 49-59 years have enrolled. At all time points tested post-methimazole treatment relative to baseline age/sex matched no-methimazole control patients, there were significant increases in plasma H2S production capacity (table). Conclusions: In this early cohort, it appears methimazole treatment in recurrent GBM patients enhances HPC on a systemic level. Next steps will be to measure sulfide signaling and sulfhydration alterations in patient tumor samples. The protocol is being modified to allow earlier addition (2 weeks) of post-op chemotherapy. Clinical trial information: NCT05607407 . [Table: see text]
Promotion of cooperation by payoff-based view radii in different interaction modes
Authors: Gao Shun , Han Wenchen , Li Haihong , Dai Qionglin , Yang Junzhong
Published: June 2024

In this letter, we introduce the payoff-based view radii into evolutionary prisoner's dilemma games performed in a two-dimensional plane and study how the adaptive view radii affect cooperation. Two types of feedback are considered, positive feedback and negative one. In the case of positive feedback, high-payoff (low-payoff) agents have large (small) view radii. In the case of negative feedback, the things are opposite. Meanwhile, three different interaction modes are considered, one-way visual interaction, proactive visual interaction, and two-way visual interaction. Our results show that the payoff-based view radii could promote cooperation effectively in all cases. Especially, there exist optimal behaviors of cooperation for both positive feedback and negative feedback. When agents are allowed to move, we find that the cooperation level could be further improved by slow migration. Our results shed light on the promotion of cooperation by the adaptive view radii and suggest different ways to adjust view radii to achieve high cooperation levels in different interaction modes.
Selected Writings on Visual Arts and Culture
Authors: Hall Stuart
Published: June 2024

Stuart Hall’s work on culture, politics, race, and media is familiar to readers throughout the world. Equally important was his decades-long commitment to visual art. As the first collection to bring together Hall’s work on the visual, this volume assembles two dozen of Hall’s essays, lectures, reviews, catalog texts, and conversations on art, film, and photography. Providing rare insights into Hall’s engagement with the “radically different” intellectual and aesthetic space of the visual imaginary, these works articulate the importance of the visual as a site of contestation at the same time as it is a space in which Black artists and filmmakers reframe questions about diaspora, identity, and globalization. Selected Writings on Visual Arts and Culture demonstrates the breadth and range of Hall’s thinking on art, film, photography, archives, and museums. In so doing, it enables us to arrive at radical and innovative ways of understanding the world.
Unraveling the molecular mechanism of novel leukemia mutations on NTRK2 (A203T & R458G) and NTRK3 (E176D & L449F) genes using molecular dynamics simulations approach
Authors: M Al-Subaie Abeer , Kamaraj Balu , Ahmad Fazil , Alsamman Khaldoon
Published: June 2024

Background: NTRK1, NTRK2, and NTRK3 are members of the neurotrophic receptor tyrosine kinases (NTRK) family, which encode TrkA, TrkB, and TrkC receptors, respectively. Hematologic cancers are also linked to point mutations in the NTRK gene's kinase domain. Trk fusions are the most common genetic change associated with oncogenic activity in Trk-driven liquid tumors. Thus, point mutations in NTRK genes may also play a role in tumorigenesis. The structural and functional effect of mutations in Trk-B & Trk-C proteins remains unclear. Methods: In this research, Homology (threading-based approach) modeling and the all-atom molecular dynamics simulations approaches are applied to examine the structural and functional behavior of native and mutant Trk-B and Trk-C proteins at the molecular level. Results: The result of this study reveals how the mutations in Trk-B (A203T & R458G) and Trk-C (E176D & L449F) proteins lost their stability and native conformations. The Trk-B mutant A203T became more flexible than the native protein, whereas the R458G mutation became more rigid than the native conformation of the Trk-B protein. Also, the Trk-C mutations (E176D & L449F) become more rigid compared to the native structure. Conclusions: This structural transition may interrupt the function of Trk-B and Trk-C proteins. Observing the impact of NTRK-2/3 gene alterations at the atomic level could aid in discovering a viable treatment for Trk-related leukemias.
Health care workers hospitalized for COVID-19 in Liberia: who were they, and what were their outcomes?
Authors: Lehyen Darius B. , Ako-Egbe Louis , Dwalu Emmanuel , Vonhm Benjamin T. , Thekkur Pruthu , Zachariah Rony , Bawo Luke
Published: June 2024

Background Sustaining a ‘fit-for-purpose’ health workforce requires a better understanding of the health care worker cadres that are affected during pandemics and their outcomes. In hospitalized health care workers with confirmed COVID-19 between March 2020 and May 2023 in Liberia, we determined the hospitalization and case fatality rates, type of health care worker cadres affected, their demographic and clinical characteristics and hospital exit outcomes. Methods This was a cohort study using routine data extracted from hospitalization forms for health care workers in 24 designated COVID-19 treatment facilities in Liberia. Results Of the 424 health care workers with COVID-19, hospitalization rates progressively declined between 2020 and 2023, with the highest rates in 2020 (24/1,000 health care workers) and 2021 (14/1,000 health care workers). Case fatality was 2% in both 2020 and 2021 with no deaths thereafter. Among those hospitalized, the highest proportions were nursing cadres with 191(45%), physicians with 63 (15%) and laboratory technicians with 42 (10%). The most frequent reported site for COVID-19 infection was the health facility (326, 89%). COVID-19 vaccination coverage in health care workers was 20%. The majority (91%) of hospitalizations were for mild symptomatic infections. Even in referral centres (n-52), 18 (35%) were for mild infections. Of the 424 who were hospitalized, 412 (97%) recovered, 9 (2%) died and 3 (1%) either left against medical advice or absconded. Of the nine deaths, none were vaccinated, seven had moderate-to-severe disease but were not referred to specialized COVID-19 treatment centers. Conclusions The hospitalized health care workers for COVID-19 were predominantly clinical and laboratory personnel who were mostly unvaccinated, and health facilities were hot-spots for contracting infections. The triage and referral system was weak with unnecessary hospitalization of mild infections. This study provides useful insights for outbreak preparedness including priority vaccination and improving health care worker safety in Liberia.
Talent management of library and information science professionals: A review of research and future directions
Authors: Rautaray Bijayalaxmi , Swain Dillip K , Swain Chandrakant
Published: June 2024

Background This study aims to review the extant literature on talent management with the objective of influencing library and information management by addressing the key facets of talent management, such as talent management strategies, importance of career development, evaluation of talented employees, and organizational resilience. Methodology Literature on the development of talent and career management was retrieved from various scholarly papers indexed in Scopus and Web of Science to have a meticulous literature review serving as the platform of the present study. In light of the authors’ observations, two models were developed. The extant literature provides precise information that talent management plays a decisive role in promoting organizational excellence invariably in all kinds of organizations in general and libraries in particular. Results This study provides constructive recommendations for the implementation of effective talent management and retention policies for library and information professionals. Moreover, this study adds immense value to the corpus of existing literature to set a platform for the augmentation of library management in futuristic vision. Conclusion This study provides constructive recommendations to policy makers and library administrators to foster talented employees for excelling library and information services for the next several decades.
Altmetric coverage of health research in Ireland 2017-2023: a protocol for a cross-sectional analysis
Authors: Sharp Melissa K , Logullo Patricia , Murphy Pádraig , Baral Prativa , Burke Sara , Grimes David Robert , Ryan Máirín , Clyne Barbara
Published: June 2024

Background Scientific publications have been growing exponentially, contributing to an oversaturated information environment. Quantifying a research output’s impact and reach can cannot be solely measured by traditional metrics like citation counts as these have a lag time and are largely focused on an academic audience. There is increasing recognition to consider ‘alternative metrics’ or altmetrics to measure more immediate and broader impacts of research. Better understanding of altmetrics can help researchers better navigate evolving information environments and changing appetites for different types of research. Objectives Our study aims to: 1) analyse the amount and medium of Altmetric coverage of health research produced by Irish organisations (2017 – 2023), identifying changes over time and 2) investigate differences in the amount of coverage between clinical areas (e.g., nutrition vs. neurology) and, where possible, by study types (e.g., clinical trials vs. evidence syntheses). Methods Using Altmetric institutional access, we will gather data on research outputs published 1 January 2017 through 31 December 2023 from active Irish organisations with Research Organisation Registry (ROR) IDs. Outputs will be deduplicated and stratified by their Australian and New Zealand Standard Research Classification relating to ≥1 field of health research: Biological Sciences, Biomedical and Clinical Sciences, Chemical Sciences, Health Sciences, and Psychology. We will clean data using R and perform descriptive analyses, establishing counts and frequencies of coverage by clinical area and medium (e.g., traditional news, X, etc.); data will be plotted on a quarterly and yearly basis. We will use topic modelling using latent Dirichlet allocation to explore prevalent topics over time. Results and Conclusions Improved understanding of one’s information environment can help researchers better navigate their local landscapes and identify pathways for more effective communication to the public. All R code will be made available open-source, allowing researchers to adapt it to evaluate their local landscapes.
Democracy and free market? Doubtful conditionality of U.S. economic incentives toward sub-Saharan Africa (2018-2021)
Authors: Matera Paulina
Published: June 2024

Background This article examines the use of economic incentives by the United States to support its main foreign policy objectives in sub-Saharan African countries. It offers an empirical survey based on available data on US foreign aid and grants awarded by the U.S. International Development Finance Corporation and the Prosper Africa initiative. The research questions are as follows: 1) Can we observe the stated conditionality of applying economic incentives to countries making progress in the process of democratisation and increasing economic freedom? 2) Which U.S. foreign policy objective is most supported by the economic incentives offered to sub-Saharan African countries? Methods I examine whether countries that are the main recipients of US economic incentives show progress in terms of democracy and economic freedom. I did this based on the data of Freedom House and Heritage Foundation. I also assess whether the US is taking up competition with China in these countries, as well as their importance in US security policy. I did this based on the data from official websites. The starting point of the analysis is 2018, when then-President Donald Trump launched programs to increase economic cooperation with sub-Saharan African countries. The end date is 2021, which includes the last full data available on all US economic incentives under consideration. Results Security cooperation is a priority goal in U.S. policy towards Sub-Saharan Africa supported by economic incentives, and the conditionality associated with democratisation and economic reform is much less important. Conclusions The lack of consistency in declared conditionality and in the application of economic incentives is striking. U.S. policy towards Sub-Saharan African states lacks a coherent strategy and actions are taken ad hoc in times of crisis. Furthermore, the development programmes proposed by successive administrations are merely an attempt to improve existing ones.
Partial minimization over the Nehari set and applications to elliptic equations
Authors: Chavez Omar Cabrera
Published: June 2024

We present a general scheme to find variationally characterized critical points
of a functional $I\colon H \to \mathbb{R}$ on a Hilbert space $H$ with hypothesis
where the usual Nehari method is not directly applicable. These critical points arise
as minima of $I$ over a suitable subset of the associated Nehari set and are
obtained with the aid of fibering methods. Moreover, we derive a comparison
result with mountain pass critical values. The abstract results will be applied to classes of logarithmic Choquard and nonlinear Schrödinger equations.
A multiplicity result for critical elliptic problems involving differences of local and nonlocal operators
Authors: Perera Kanishka , Sportelli Caterina
Published: June 2024

We study some critical elliptic problems involving the difference of two nonlocal operators, or the difference of a local operator and a nonlocal operator.
The main result is the existence of two nontrivial weak solutions, one with negative energy and the other with positive energy, for all sufficiently small values
of a parameter.
The proof is based on an abstract result recently obtained in \cite{MR4293883}.
Los derechos colectivos de los consumidores: una mirada a su justificación y a su defensa mediante las acciones populares
Authors: Hernández-Zambrano David , López-Castro Yira
Published: June 2024

Este texto propone una mirada general a la historia y la justificación de los derechos de los consumidores como derechos colectivos y una presentación de su defensa a través de las acciones populares. El capítulo hace un recorrido por los inicios de la protección de los intereses de los individuos en cuanto consumidores, los cuales aparecen en Estados Unidos y Europa en la segunda mitad del siglo XX. Así, se muestra que el derecho del consumo aparece como una reacción al derecho privado liberal fundado en la igualdad formal. Respecto al panorama local, el capítulo presenta la regulación que precedió al reconocimiento constitucional de los derechos de los consumidores y las razones que llevaron al constituyente a categorizarlos como derechos colectivos. De esa forma, el texto analiza cómo la vulnerabilidad y la posición de inferioridad de los consumidores en las transacciones masivas que ocurren en el mercado son las características que hacen de los consumidores un colectivo con la legitimación para exigir una protección indivisible de sus derechos mediante la acción popular.
The Divergent Effect of Competition on Platforms: Deterring Recruits, Motivating Converts
Authors: Nagaraj Abhishek , Piezunka Henning
Published: June 2024

Knowledge platforms differ in how they source their knowledge; they can be categorized as traditional (e.g., Encyclopedia Britannica, Guide Michelin) or crowdsourced (e.g., Wikipedia, Yelp). Although research has compared and contrasted the two, we study how they compete with one another. In particular, we focus on how competition from traditional platforms affects volunteers’ contributions to crowdsourced platforms. We propose a divergent effect: competition increases individual contributions from volunteers who were already active before the entry of any competitor (pre-entry contributors). However, competition also hinders recruitment and therefore leads to a decrease in total contributions from the set of volunteers who are new to the platform in a given time period (newly recruited contributors). We suggest the first effect is driven by pre-entry contributors’ ideological attachment, whereas the second is driven by lower awareness of the platform postcompetitive entry. To test our theory, we leverage and examine how the phased entry of Google Maps in different countries affects contributions to OpenStreetMap, a crowdsourced mapping platform. We find the hypothesized divergent effects and provide suggestive evidence of the underlying mechanisms. We contribute to research on crowdsourcing, volunteers’ willingness to contribute, platform competition, and on the effect of competition on organizations more broadly.

Funding: The authors acknowledge the financial support of the INSEAD Alumni Fund.

Supplemental Material: The online appendices are available at https://doi.org/10.1287/stsc.2022.0125 .
Metastatic clear cell sarcoma of the pancreas: A sporadic cancer
Authors: Gebbia Vittorio , Carnaghi Carlo
Published: June 2024

Primary or secondary clear cell sarcoma of the pancreas is an exceedingly rare and aggressive disease. In addition to pathology, molecular analysis is pivotal in differential diagnosis, especially with malignant melanoma. A key aspect in identifying clear cell sarcoma is specific genetic alterations, notably the translocation of t(12;22) (q13;q13), a diagnostic hallmark of this sarcoma subtype, which is absent in malignant melanoma. Treatment of primary clear cell sarcoma of the pancreas is the same as that for adenocarcinoma.
Effect of cetuximab plus FOLFOX4 regimen on clinical outcomes in advanced gastric carcinoma patients receiving evidence-based care
Authors: Ying Hui , Huang Ren-Jun , Jing Xiao-Min , Li Yan , Tong Qun-Qiu
Published: June 2024

BACKGROUND

Although chemotherapy is effective for treating advanced gastric carcinoma (aGC), it may lead to an adverse prognosis. Establishing a highly effective and low-toxicity chemotherapy regimen is necessary for improving efficacy and outcomes in aGC patients.

AIM

To determine the efficacy and safety of cetuximab (CET) combined with the FOLFOX4 regimen (infusional fluorouracil, folinic acid, and oxaliplatin) as first-line therapy for patients with aGC, who received evidence-based care (EBC).

METHODS

A total of 117 aGC patients who received EBC from March 2019 to March 2022 were enrolled. Of these, 60 in the research group (RG) received CET + FOLFOX4 as first-line therapy, whereas 57 in the control group (CG) received FOLFOX4. The efficacy [clinical response rate (RR) and disease control rate (DCR)], safety (liver and kidney dysfunction, leukopenia, thrombocytopenia, rash, and diarrhea), serum tumor marker expression [STMs; carbohydrate antigen (CA) 19-9, CA72-4, and carcinoembryonic antigen (CEA)], inflammatory indicators [interleukin (IL)-2 and IL-10], and quality of life (QOL) of the two groups were compared.

RESULTS

A markedly higher RR and DCR were observed in the RG compared with the CG, with an equivalent safety profile between the two groups. RG exhibited notably reduced CA19-9, CA72-4, CEA, and IL-2 levels following treatment, which were lower than the pre-treatment levels and those in the CG. Post-treatment IL-10 was statistically increased in RG, higher than the pre-treatment level and the CG. Moreover, a significantly improved QOL was evident in the RG.

CONCLUSION

The CET + FOLFOX4 regimen is highly effective as first-line treatment for aGC patients receiving EBC. It facilitates the suppression of STMs, ameliorates the serum inflammatory microenvironment, and enhances QOL, without increased adverse drug effects.
Application of prostate resectoscope in the treatment of massive rectal bleeding after transrectal prostate puncture
Authors: Li Hong-Mei , Yang Fa-Ying , Tu Song , Yan Peng , Qian Jun , Yao Jia-Xi
Published: June 2024

BACKGROUND

Ultrasound-guided prostate biopsy is a reliable diagnostic procedure for prostate cancer diagnosis with minimal procedure-related trauma. However, complications, such as massive rectal bleeding may occur after the puncture. We hypothesized that using a transrectal resectoscope could help treat massive rectal bleeding after transrectal prostate punctures.

AIM

To identify a simple and effective treatment for massive rectal bleeding after transrectal prostate punctures.

METHODS

Patients requiring treatment for massive rectal bleeding after transrectal prostate punctures were included. A SIMAI resectoscope was inserted through the anus. Direct electrocoagulation was performed for superficial bleeding points. Part of the rectal mucosa or surface muscle layer was removed to expose deep bleeding points, followed by electrocoagulation. An electric cutting ring was used to compress and stop the bleeding for jet-like points before electrocoagulation. The fluid color in the drainage tube was monitored postoperatively for continuous bleeding.

RESULTS

Eight patients were included from 2012 to 2022. None of the patients with massive rectal bleeding after the transrectal prostate punctures improved with conventional conservative and blood transfusion treatments. Two patients had an inferior artery embolism, and digital subtraction angiography was ineffective. All patients received emergency transanal prostate resection, which immediately stopped the bleeding. Four days after the procedure, the patients had recovered and were discharged.

CONCLUSION

Using a transanal prostate resection instrument is a simple, safe, and effective method for treating massive rectal bleeding after transrectal prostate punctures.
Laryngeal leiomyoma: A case report and review of literature
Authors: Wu Yu , Li Jing-Man , Zhang Tian-Jiao , Wang Xin
Published: June 2024

BACKGROUND

Leiomyomas (LMs) are mesenchymal tumors that arise from smooth muscle cells. LMs most commonly arise in organs with an abundance of smooth muscle such as the uterus and gastrointestinal tract. Conversely, LMs are rarely detected in the head and neck region. In this study, we report a rare case of laryngeal LM (LLM) and summarized the clinical characteristics of reported LLMs to help clinicians better understand this rare disease and improve its diagnosis, treatment, and postoperative course.

CASE SUMMARY

A 49-year-old man was admitted to our ENT outpatient clinic with a chief complaint of pharynx discomfort for 2 months. Laryngoscopy performed under topical anesthesia revealed a solitary, pink mass at the tubercle of epiglottis. Surgery via laryngeal endoscopy was performed under general anesthesia, and the lesion was excised easily. Positive immunohistochemical staining for desmin and smooth-muscle actin indicated a smooth muscle origin and the diagnosis was laryngeal leiomyoma. After surgery, the patient’s condition was stable, and he was discharged 2 d after surgery. During the 1-year postoperative period, the patient’s condition remained stable without evidence of recurrence.

CONCLUSION

Surgical resection is the preferred treatment for LLMs, its early diagnosis and differential diagnosis have important clinical significance.
Complex heterozygous mutations in hereditary spherocytosis: A case report
Authors: He Miao , Lv Yan-Cheng , Wei Yu-Hong , Liu Lan-Qin , Guo Ling , Li Cheng
Published: June 2024

BACKGROUND

The aim of this study was to investigate the complex heterozygous mutations of ANK1 and SPTA1 in the same individual and improve our understanding of hereditary spherocytosis (HS) in children. We also hope to promote the application of gene detection technology in children with HS, with the goals of identifying more related gene mutations, supporting the acquisition of improved molecular genetic information to further reveal the pathogenesis of HS in children, and providing important guidance for the diagnosis, treatment, and prevention of HS in children.

CASE SUMMARY

A 1-year and 5-month-old patient presented jaundice during the neonatal period, mild anemia 8 months later, splenic enlargement at 1 year and 5 months, and brittle red blood cell permeability. Genetic testing was performed on the patient, their parents, and sister. Swiss Model software was used to predict the protein structure of complex heterozygous mutations in ANK1 and SPTA1 . Genetic testing revealed that the patient harbored a new mutation in the ANK1 gene from the father and a mutation in the SPTA1 gene from the mother. Combined with the clinical symptoms of the children, it is suggested that the newly discovered complex heterozygous mutations of ANK1 and SPTA1 may be the cause, providing important guidance for revealing the pathogenesis, diagnosis, treatment, and promotion of gene detection technology in children with HS.

CONCLUSION

This case involves an unreported complex heterozygous mutation of ANK1 and SPTA1 , which provides a reference for exploring HS.
Intensive care unit-acquired weakness and mechanical ventilation: A reciprocal relationship
Authors: Sinha Ranjeet Kumar , Sinha Sony , Nishant Prateek , Morya Arvind Kumar
Published: June 2024

Intensive care unit-acquired weakness (ICU-AW; ICD-10 Code: G72.81) is a syndrome of generalized weakness described as clinically detectable weakness in critically ill patients with no other credible cause. The risk factors for ICU-AW include hyperglycemia, parenteral nutrition, vasoactive drugs, neuromuscular blocking agents, corticosteroids, sedatives, some antibiotics, immobilization, the disease severity, septicemia and systemic inflammatory response syndrome, multiorgan failure, prolonged mechanical ventilation (MV), high lactate levels, older age, female sex, and pre-existing systemic morbidities. There is a definite association between the duration of ICU stay and MV with ICU-AW. However, the interpretation that these are modifiable risk factors influencing ICU-AW, appears to be flawed, because the relationship between longer ICU stays and MV with ICU-AW is reciprocal and cannot yield clinically meaningful strategies for the prevention of ICU-AW. Prevention strategies must be based on other risk factors. Large multicentric randomized controlled trials as well as meta-analysis of such studies can be a more useful approach towards determining the influence of these risk factors on the occurrence of ICU-AW in different populations.
Decomposition Analysis of CO2 Emissions in Greece from 1996 to 2020
Authors: Tsepi Eleni , Sebos Ioannis , Kyriakopoulos Grigorios L.
Published: June 2024

To meet Greece’s commitments under the Kyoto Protocol (KP) and the UN Framework Convention on Climate Change (UNFCCC), it’s crucial to dissect the primary influencers of its greenhouse gas emissions. This study utilized the logarithmic mean Divisia index method in its additive form to delve into the main drivers behind carbon dioxide emissions in Greece from 1996 to 2020. The analysis revealed that the primary catalyst for the rise in CO2 emissions was the growth in GDP. Conversely, advancements in energy efficiency, as indicated by a decrease in energy intensity, played a significant role in reducing CO2 emissions. While population growth contributed to an increase in emissions, a decline in emissions intensity showcased a reduction in emissions per unit of output or consumption. The period from 1996 to 2020 witnessed a 38% change in emissions, demonstrating the effectiveness of Greece’s environmental policies. These findings highlight the pressing need for a sustained focus on enhancing renewable energy sources (RES) penetration and ensuring comprehensive attention across all sectors to further reduce emissions.
Study on Zoning Effect of Shallow Geothermal Energy Suitability Based on Structural Matrix Method
Authors: Ge Yan , Sen Yunfei , Yang Zhen
Published: June 2024

Geothermal energy is a clean, renewable resource that can be harnessed to help China achieve its twofold carbon goal and advance its energy security policy. Shallow geothermal, middle-deep geothermal, and dry hot rock geothermal all belong to the clean energy. The thermal energy held in rock, soil, groundwater, and surface water up to a depth of 200 metres is referred to as the shallow geothermal variety, which is characterized by temperatures below 25∘C. Its use is mostly dependent on ground source heat pump technology. The ground source heat pump ground pipe heat exchange system, the ground source heat pump groundwater heat exchange system, and the ground source heat pump surface water heat exchange system are all included in the shallow geothermal heat exchange mechanism. The structural matrix approach is used in this study to determine if the groundwater heat exchange system for the shallow geothermal ground source heat pump in Sanmenxia’s urban setting is appropriate. The results showed that: the most influential factor was hydrogeological conditions, followed by hydrodynamic and water chemistry conditions. Aquifer recharge capacity and water capacity was the necessary condition of suitability partition. Studied hydrodynamic field and chemical field, analyzed aquifer thickness and groundwater flow under current conditions and determined the appropriate zoning, proposed groundwater aquifers and recharge horizon.
Modelling and Assessing the Advantages of Integrating Wind, Solar, and Coal Systems within an Annual Bilateral Trading Setting
Authors: Yiqun Meng , Guoliang Bian , Yi Gu , Chuang Liu , Bo Hu , Guiping Zhou , Huanhuan Luo , Yuanzhu Zhao , Yiming Chang , Zhonghui Wang
Published: June 2024

The integration and co-location of new energy sources and thermal power generation within the same grid connection point, under the management of a single market operator, provide noteworthy potential for exploration in the northern part of our nation. This method is based on the premise of allocating new energy resources primarily for generating contracted electricity, while using thermal power to offer ancillary services. This strategy aims to integrate and use the distinct benefits of both thermal power and new energy sources. The yearly bilateral trade market has significant potential for growth and development. In order to model and evaluate the income generated by the interconnected system’s involvement in the yearly bilateral trading market, this study first establishes the definition of the interconnected system and examines its research significance in engaging in annual bilateral trading. This study utilizes the theoretical framework of master-slave games to analyze the involvement of a coupled system in yearly bilateral trade. The specific case examined in this research is a wind-solar-thermal coupling system located in a particular location of Liaoning Province. This study examines the economic advantages of engaging in the electricity market by considering the marginal cost and LCOE (Levelized Cost of Electricity) perspectives. The findings suggest a notable enhancement in the advantages of the integrated system inside the yearly bilateral trade market, in contrast to conventional power sources present in the market, as well as instances when these sources function autonomously without integration.
Padronização das condições de amplificação de marcadores SSR em Physalis angulata L.
Authors: Francisco Gregório do Nascimento Neto  , Luiz Claudio Costa Silva
Published: June 2024

O gênero Physalis possui na América do Sul seu principal centro de diversidade e endemismo (SOUZA e LORENZI, 2012). O gênero é bastante distribuído em todas as regiões do Brasil, ocorrendo nos domínios fitogeográficos Amazonas, Caatinga, Cerrado, Mata Atlântica e Pantanal. A Physalis é pouco cultivada no Brasil, apesar de seu fruto ser rico em nutrientes muito importantes para a alimentação humana, como ferro, fósforo, vitamina A e C, e substâncias como carotenoides e flavonoides, que apresentam açãoantioxidante contra o envelhecimento, além de ter lugar de destaque pela presença de substâncias às quais possuem várias atividades farmacológicas, como os metabólitos polioxigenados e vitaesteroides (TOMASSINI et al., 2000).
CARACTERIZAÇÃO BIOQUÍMICA DE FRUTOS DE POPULAÇÃO F2 DE Physalis angulata L.
Authors: Ian de Oliveira Souza  , Luiz Claudio Costa Silva
Published: June 2024

O nome Physalis tem origem grega, e o termo “Physa” é dado em relação ao cálice permanente que envolve o fruto, significando “bolha” ou “bexiga”. A morfologia característica do gênero a torna facilmente reconhecida, de modo especial na frutificação, onde as espécies do mesmo apresentam um cálice inflado que reveste e protege o fruto por inteiro. Mesmo que boa parte destas espécies tenha potencial para alimentação, por ainda não ser popularmente prestigiada, não são cultivadas no Brasil (FARIAS, 2020).
Curva temperatura-tempo do candombá em chamas: o primeiro passo para avaliar se Vellozia pyrantha pode florescer sem fogo
Authors: Jamine Maia Rocha  , Abel Augusto Conceicao
Published: June 2024

Popularmente conhecida como “candombá”, Vellozia pyrantha A.A.Conc. (Velloziaceae) é uma planta utilizada localmente no entorno do Parque Nacional da Chapada Diamantina (PNDC) para acender fogões a lenha, devido à elevada flamabilidade da resina laranja presente nos seus ramos (Oliveira et al. 2015). A maior parte do pseudocaule é formada pela fusão de bainhas foliares da roseta apical, constituindo uma estrutura grossa que protege o caule contra as altas temperaturas do fogo (Conceição et al. 2017).
Flora da Bahia: Maprounea Aubl. (Euphorbiaceae)
Authors: Da Luz Silva Marilane , Daniela Santos Carneiro Torres
Published: June 2024

Maprounea pertence à família Euphorbiaceae, subfamília Euphorbioideae, tribo Hippomaneae (Webster 1994; 2014). Trata-se de um pequeno gênero que inclui hábitos arbustivos e arbóreos, com ocorrência nos Neotrópicos e na África (Esser 2014).
PROPAGAÇÃO E MANUTENÇÃO DO BANCO ATIVO DE GERMOPLASMA DE Lippia Origanoides E Eplingiella Fruticosa DA COLEÇÃO DE PLANTAS MEDICINAIS E AROMÁTICAS DO HORTO FLORESTAL DA UEFS
Authors: Milena dos Reis Santos de Queiroz  , Lenaldo Muniz de Oliveira
Published: June 2024

Conservar os recursos genéticos de plantas medicinais é algo essencial para a humanidade, dado ao grande uso popular e industrial dessas espécies.
Detecção e Clonagem da enzima lacase de espécies do gênero Ganoderma em células de E. coli
Authors: Rafaela dos Anjos Rocha  , Helio Mitoshi Kamida
Published: June 2024

A lignina é uma macromolécula presente na parede celular de plantas, que as confere rigidez. Sua degradação complexa dificulta o acesso aos polímeros de carboidrato lignocelulolíticos. Nesse sentido o fungo da espécie Ganoderma australe produz lignases,sendo capazes de realizar a síntese da lignina.
HORTAS URBANAS E SUA IMPORTÂNCIA NA MANUTENÇÃO DAS ABELHAS: UM ESTUDO DE CASO EM FEIRA DE SANTANA - BA
Authors: Ruama Mascarenhas Lopes  , Candida Maria Lima Aguiar de Mendonça
Published: June 2024

A urbanização causa impactos negativos no ambiente, afetando a biodiversidade, especialmente os insetos polinizadores. O declínio desses insetos é preocupante devido à sua importância na manutenção dos serviços ecossistêmicos (Imperatriz-Fonseca et al., 2007). O aumento do uso de pesticidas, as mudanças climáticas e a perda de habitat são fatores que contribuem para esse declínio, sendo a conversão de habitats naturais em áreas agrícolas o principal impulsionador desse problema, promovendo a redução na disponibilidade de locais adequados para a nidificação e a diversidade floral para várias espécies de abelhas (Kline et al., 2020).
OS PRINCÍPIOS DA BIOÉTICA NO ACOLHIMENTO AOS FAMILIARES DE INDIVÍDUOS HOSPITALIZADOS SOB A ÓTICA DOS ENFERMEIROS
Authors: Déborah de Oliveira Souza  , Elaine Guedes Fontoura
Published: June 2024

A bioética trata da ética da vida e tem como princípios norteadores a autonomia, beneficência, justiça e não maleficência (SANTOS, 2017) que são bases que favorecem o respeito à dignidade humana.
A INSERÇÃO DAS TECNOLOGIAS DA INFORMAÇÃO E COMUNICAÇÃO (TIC) NAS AULAS DE EDUCAÇÃO FÍSICA DAS ESCOLAS BAIANAS NOS TERRITÓRIOS DE IDENTIDADE PIEMONTE DA DIAMANTINA E PORTAL DO SERTÃO: DESAFIOS E POSSIBILIDADES
Authors: Erick Vinícios dos Santos Moreira  , Suzana Alves Nogueira Souza
Published: June 2024

A humanidade, em seu desenvolvimento contínuo, apresenta, a partir de seus avanços tecnológicos, novos dispositivos eletrônicos e, com eles, novas formas de interagir entre as pessoas e vivenciar o mundo, caracterizando “o surgimento de uma teia global de conexões – que se efetivam via dispositivos de hardware e interfaces – formando em sua totalidade um espaço-informação, ou o ciberespaço” (BARACHO; GRIPP; LIMA, 2012, p. 112, grifos dos autores).
O CUIDADO PROFISSIONAL À MULHER VÍTIMA DE VIOLÊNCIA DOMÉSTICA
Authors: Eunice Gabriela de Oliveira Araújo  , Rosana Oliveira de Melo
Published: June 2024

O termo cuidado pode ser definido como demonstração de atenção; aplicação e capricho ao realizar algo; zelo, esmero ou dever de arcar com seus próprios comportamentos ou com as ações de outrem (DICIO, 2022). Essas definições são muito superficiais quando relacionadas a ações de saúde, isso porque, nessa área, o cuidado é visto de forma mais ampla, observado como uma forma de ser, de expressão, e acontece com base nas relações que se estabelecem entre os sujeitos.
AVALIAÇÃO DA CONDIÇÃO DE SAÙDE BUCAL COM ENFOQUE A CÁRIE DE RADIAÇÂO EM PACIENTES SOB RADIOTERAPIA DE CABEÇA E PESCOÇO
Authors: Jéssica dos Santos Nunes  , Angela Guimaraes Martins
Published: June 2024

Dentre as inúmeras neoplasias malignas encontra-se o câncer de cabeça e pescoço (CCP), termo coletivo estabelecido por bases anatômico-topográficas que engloba a cavidade oral, laringe, faringe e cavidade nasal (INCA, 2020).
AVALIAÇÃO DOS NÍVEIS DE DOR EM PORTADORES DA SÍNDROME DA ARDÊNCIA BUCAL PRIMÁRIA E SECUNDÁRIA: UMA REVISÃO DE LITERATURA
Authors: Maryanne Lopes de Barros Lima  , Marcio Campos Oliveira
Published: June 2024

A síndrome de ardência bucal (SAB) é um distúrbio de dor crônica, de caráter multifatorial e caracterizada por uma sensação de queimação da mucosa oral (Feller, 2017; Oliveira, 2013).
ESTUDO IN SILICO DA INTERAÇÃO DE ALCALOIDES COM A ACETILCOLINESTERASE DE Rhipicephalus microplus
Authors: Da Cunha Santos Matheus , Mariana Borges Botura
Published: June 2024

O controle de doenças parasitárias em ruminantes é um importante fator para o incremento da produtividade da agropecuária no Brasil. As infestações pelo carrapato Rhipicephalus microplus são responsáveis por elevados prejuízos econômicos (JUNIOR, et al., 2019).
FATORES DE RISCO PARA OCORRÊNCIA DE LESÕES NO COMPLEXO MAMILO AREOLAR NO PUERPÉRIO
Authors: Nathália Yasmim dos Santos Assis  , Karine Emanuelle Peixoto de Souza
Published: June 2024

O aleitamento materno exclusivo (AME) é reconhecido pela Organização Mundial da Saúde (OMS) e Ministério da Saúde (MS) (BRASIL, 2019) como um exercício valioso para mãe e bebê, sendo recomendado pelo menos até os 6 primeiros meses, pois além dos aspectos nutricionais atua na diminuição da taxa de mortalidade e melhora a saúde do recém-nascido.
Papel da inflamação estimada pela Razão Neutrófilo-Linfócito (RNL) na noctúria em homens
Authors: Thifany Novais de Paula  , José de Bessa Junior
Published: June 2024

Noctúria é um sintoma do trato urinário inferior caracterizado pela necessidade de acordar para urinar durante o período principal de sono, com cada micção seguida de sono ou a intenção para dormir (HASHIM et al., 2019).
ACESSIBILIDADE DA PESSOA IDOSA NA ATENÇÃO PRIMÁRIA À SAÚDE EM TEMPOS DE PANDEMIA
Authors: Vanúzia Vitória de Carvalho Franco  , Silvania Sales de Oliveira
Published: June 2024

A pandemia da COVID-19 provocada pela disseminação e infecção em escala mundial do vírus SARS-COV-2 mudou os padrões de vida de toda a população e apresentou um efeito ainda mais marcante sobre a população idosa.
Projetos Pedagógicos dos Cursos de Graduação da Área da Saúde na Bahia: estudo comparado dos objetivos pedagógicos, conteúdos, competências e habilidades para a formação profissional na Atenção Primária à Saúde
Authors: Vinícius de Oliveira Silva  , Marcelo Torres Peixoto
Published: June 2024

Os modelos de atenção à saúde implementados pelos diferentes países sempre estiveram associados aos contextos histórico, político, econômico e social mundial e também às especificidades locais de cada sociedade. Na década de setenta do século XX, construiu-se um debate internacional em torno da melhoria da organização do setor saúde como um instrumento para diminuir as desigualdades sociais.
CIRCULANDO O ATLÂNTICO ESCRAVISTA EM LIBERDADE: UMA ANÁLISE DOS PASSAPORTES DE AFRICANOS LIBERTOS (BAHIA, 1824- 1850)
Authors: Ariadne Vitoria Silva Santos  , Carlos Francisco da Silva Junior
Published: June 2024

No período da ilegalidade do tráfico para o Brasil a circulação de pessoas nas travessias atlânticas direta ou indiretamente conectadas pelo tráfico de escravos foi brutalmente intensificada. Esse movimento concentrou-se principalmente em duasregiões: a África Ocidental (ou a Costa da Mina, atuais Togo, Benim e Nigéria) e a África Centro Ocidental (Angola).
MATERNAGEM NEGRA E AMOR NO PENSAMENTO DE BELL HOOKS: UM CAMINHO DE RECONHECIMENTO E RESISTÊNCIA PARA A CRIANÇA NEGRA
Authors: Júlia Terena de Souza Lima Dias  , Carlos Cesar Barros
Published: June 2024

A presente pesquisa, em consonância com os objetivos específicos e gerais traçados, buscou analisar, a partir das obras e teorias da filósofa norte-americana bell hooks, o papel da maternagem negra para a formação de resistência e reconhecimento na criança negra.
Índice de Anomalia de Chuva (IAC) para a análise das precipitações de Ilhéus-Ba entre os anos de 2000-2021
Authors: Lucas Bastos da Silva Cavalcante  , Jemison Mattos dos Santos
Published: June 2024

“As mudanças climáticas são transformações a longo prazo nos padrões de temperatura e clima. Essas mudanças podem ser naturais, como por meio de variações no ciclo solar. Mas, desde 1800, as atividades humanas têm sido o principal impulsionador das mudanças climáticas, principalmente devido à queima de combustíveis fósseis como carvão, petróleo e gás” (NACÕES UNIDAS BRASIL, 2023)
REVISITANDO O ATLAS “ESTADO DO BRASIL” (1631): ARISTOCRACIA, ERUDIÇÃO E POLÍTICA COLONIAL NA CARTOGRAFIA IBERO-AMERICANA SEISCENTISTA”
Authors: Luiz Antonio dos Santos Fonseca  , Caio Figueiredo Fernandes Adan
Published: June 2024

A pesquisa se dedicou a estudar o atlas ―Estado do Brasil‖ (1631), de autoria do cartógrafo português João Teixeira Albernaz I, o velho. O trabalho, em linhas gerais, se voltou para analisar tanto aspectos diretos relacionados à fonte, como a natureza do documento e o seu conteúdo, quanto aspectos contextuais, como o motivo da confecção do atlas, a dinâmica de sua circulação e a sua importância para a cartografia seiscentista. Portanto, a pesquisa dialogou com uma bibliografia diversificada, com aproximações com a história da cartografia, história política e história moderna.
Impactos da atividade física sobre a qualidade de vida autorreferida dos servidores no período pós-pandêmico
Authors: Kamila Barreto Silva  , Denize Pereira de Azevedo Freitas
Published: June 2024

A relação Atividade Física (AF) e Qualidade de Vida (QV) não é recente, há muito se busca compreender melhor de que maneira ambas podem promover melhores condições de vida e trabalho, já que há décadas as pessoas passaram a vivenciar a maior parte de suas vidas em seus locais de trabalho direcionando sua força e energia vital para manter a dinâmica laboral do capital.