bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine Learning‐Based Psychology Evaluation of College Students for Building Innovative Health Service System
Authors: Zhang Xi
Published: September 2022

Leadership psychology among college students is a multidimensional concept that primarily encompasses practical ability, teamwork ability, political literacy, emotional intelligence, etc. At present, a common problem among the surveyed college students is their leadership ability is not strong. Reasons include the lack of leadership‐related knowledge and leadership awareness among college students as well as the fact that the public, particularly college educators, do not give leadership training a sufficient attention. Leadership psychology is a primary factor influencing the development of college students. It is necessary to strengthen college students’ leadership education. This work extracts the key factors that influence the leadership of college students by analyzing their big behavior data. The extracted factors include the theoretical knowledge of leadership, practical ability, leadership psychology, home education, and exercise. To evaluate the degrees of these factors influencing the students’ leadership, we develop an advanced multicriteria decision‐making framework based on the ENtropy theory and the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS), called EN‐TOPSIS. In EN‐TOPSIS, an entropy method is used to determine the criteria weights rather than using the subjective weighting method. Three groups of college students are surveyed and evaluated based on the five factors. Each group contains ten students. The evaluation results show that the leadership of the students is mainly influenced by their practical ability and leadership psychology. The students with the highest evaluation score are recognized as having high levels of leadership.
The Effects of Combuxil and Leizumab on Retinal Function and Serum Interleukin-17A in Premature Infants with Retinopathy
Authors: Ren Huixuan , Su Gang , Xu Shunian , Zhou Li , Cai Shanjun
Published: September 2022

Objective. To investigate the effects of Compaximab and raizumab on retinal function and serum interleukin-17A level in retinopathy of prematurity. Methods. Sixty cases of retinopathy of prematurity treated in our hospital from February 2019 to April 2021 were selected. The patients were randomly divided into control group (

n
=
30

) and research group (

n
=
30

). The control group was treated with Compaq and the research group was treated with razumab. The curative effect, retinal function, incidence of complications, intraocular pressure at different time, and the level of serum interleukin-17A were compared. Results. Compared with the two groups, the curative effect of the research group 93.33% (28/30) was greater than that of the control group 66.67% (20/30), and the difference was statistically significant (

P
<
0.05

). Compared with the incidence of complications, the incidence of corneal opacity, lens opacity, preretinal and vitreous hemorrhage, endophthalmitis, and traction retinal detachment in the research group was greatly lower, and the difference was statistically significant (

P
<
0.05

). Following the therapy, the IOP of the two groups decreased at different times. The IOP of 1 min, 10 min, and 30 min in the research group was obviously lower, and the difference was statistically significant (

P
<
0.05

). Following treatments, the levels of serum IL-17A were decreased. Compared with the control group, the level of serum IL-17A in the research group was greatly downregulated, and the difference was statistically significant (

P
<
0.05

). Conclusion. Intravitreal injection of razumab is an effective treatment for retinopathy of prematurity, which can effectively improve the retinal function of infants. The level of serum interleukin-17A can be reduced and intraocular pressure can be regulated, which is safe and effective.
Experimental Evaluation of Coffee Husk Ash as a Filler in Hot Mix Asphalt Concrete Productions
Authors: Tessema Amare Tilahun , Wolelaw Natnael Melsew , Alene Getachew Asefa
Published: September 2022

The use of coffee husk ash (CHA) as a mineral filler in hot mix asphalt was investigated in this study. Crushed stone dust (CSD) was used as the mineral filler in four distinct serial asphalt concrete samples (5.5%, 6.5%, 7.5%, and 8%) for this purpose. The samples’ ideal bitumen content and Marshall stability (MS) value were calculated. The 6.5% filler asphalt series, which has offered the most stability, was picked, and CHA was substituted for it at rates of 25%, 50%, 75%, and 100%. The produced samples were then subjected to an MS test, and the results were evaluated. The effects of mineral filler on the susceptibility of asphalt concrete to moisture were also examined in the present study along with the preparation and evaluation of Marshall stability mixtures with various CHA and bitumen levels. The maintained stability test also evaluates a bituminous mix’s capacity to be stripped. The findings indicated that for stability, flow, air voids, VFA, and bulk density, respectively, the optimum asphalt content (5.57%) and filling rate at 75% replacement of crushed stone dust with coffee husk ash had values of 16.820 kN, 4.983 mm, 4.435%, and 73.717%. CHA can be used as long as 75% of the CSD filler material complies with the minimum standards set by the Ethiopian Road Authority and global standards for the manufacturing of hot mix asphalt concrete. The retained stability (RS) test results showed that the retained stability values increased with an increase in bitumen content, indicating that the effect of moisture damage decreases with an increase in asphalt content because a high bitumen content will have a thicker content, which reduces the tendency for the water to percolate into the asphalt mix and cause moisture‐related problems.
In Vitro Evaluation of Extracellular Enzyme Activity and Its Biocontrol Efficacy of Bacterial Isolates from Pepper Plants for the Management of Phytophthora capsici
Authors: Admassie Mesele , Woldehawariat Yitbarek , Alemu Tesfaye
Published: September 2022

Phytophthora capsici is one of the most devastating fungal pathogens, causing severe diseases that lead to economic loss in the pepper industry. As a result of the infections, the chemical approach is becoming more popular. Biological control, on the other hand, is better suited to controlling fungal pathogens. The biological control approach significantly reduces the problems associated with chemical applications while restoring natural environmental balance. As a result, the overall findings indicate that certain bacterial isolates play a beneficial role in lytic enzyme production and biocontrol activities against P. capsici. Bacterial isolates obtained from the pepper plants were screened for lytic enzyme and anti‐oomycete activity against Phytophthora capsici in Ethiopia. Sixty bacterial isolates were isolated and tested against Phytophthora capsici. From these bacterial isolates, different inhibition zones and hydrolytic enzyme production were detected. Biochemical tests using an automated machine (MALDI‐TOF, VITEK 2 compact and 16S rRNA) revealed that three of them, AAUSR23, AAULE41, and AAULE51, showed a high inhibition zone and high production of hydrolytic enzymes and were identified as Enterobacter cloacae (AAUSR23), Pseudomonas fluorescens (AAULE41), and undetermined (AAULE51). The effects of diffusable metabolite isolate AAULE51 has a 66.7% inhibition zone against Phytophthora capsici, followed by AAULE41 and AAUSR23, which have 59.7% and 14.1% inhibition zones, respectively. These bacterial isolates showed high production of hydrolytic enzymes like protease, cellulase, chitinase, and lipase (5‐34 diameter of inhibition zone). As a result, the overall findings show that selected bacterial isolates play a beneficial role in lytic enzyme production and for their biocontrol activities against P. capsici.
Superlative Feature Selection Based Image Classification Using Deep Learning in Medical Imaging
Authors: Humayun Mamoona , Khalil Muhammad Ibrahim , Alwakid Ghadah , Jhanjhi N. Z.
Published: September 2022

Medical image recognition plays an essential role in the forecasting and early identification of serious diseases in the field of identification. Medical pictures are essential to a patient’s health record since they may be used to control, manage, and treat illnesses. On the other hand, image categorization is a difficult problem in diagnostics. This paper provides an enhanced classifier based on the outstanding Feature Selection oriented Clinical Classifier using the Deep Learning (DL) model, which incorporates preprocessing, extraction of features, and classifying. The paper aims to develop an optimum feature extraction model for successful medical imaging categorization. The proposed methodology is based on feature extraction with the pretrained EfficientNetB0 model. The optimum features enhanced the classifier performance and raised the precision, recall, F1 score, accuracy, and detection of medical pictures to improve the effectiveness of the DL classifier. The paper aims to develop an optimum feature extraction model for successful medical imaging categorization. The optimum features enhanced the classifier performance and raised the result parameters for detecting medical pictures to improve the effectiveness of the DL classifier. Experiment findings reveal that our presented approach outperforms and achieves 98% accuracy.
Algorithm Design of Port Cargo Throughput Forecast Based on the ES‐Markov Model
Authors: Yi Yan , Seyed Sadr Seyed Taha
Published: September 2022

At present, the existing prediction algorithm of a port cargo throughput neglects the correction of the initial value of the cargo series data model, which leads to a large error in a port cargo throughput prediction. Therefore, a prediction algorithm of a port cargo throughput based on the ES‐Markov model is designed. A decompose function is used to decompose the time series of a port cargo throughput, and the trend elements of a port cargo throughput are divided into long‐term trend, seasonal trend, fluctuation trend, and irregular trend. In this study, the ES‐Markov model is introduced, and the initial prediction is obtained by using the cubic exponential smoothing method, and the state transition matrix is obtained by the Markov principle. Based on the results of the time‐series analysis and the ES‐Markov model, the prediction algorithm of a port cargo throughput is designed. In the experimental design, the Elman neural network is used to construct an experimental sample data model. The monthly cargo throughput data of a certain port for eight months from May 2020 to December 2020 are collected and sorted according to the time series. The experimental results show that the prediction results of the proposed algorithm are closer to the actual value and the fluctuation of the prediction results is less than that of the reference.
A Decoupled Energy Stable Numerical Scheme for the Modified Cahn–Hilliard–Hele–Shaw System with Logarithmic Potential
Authors: Wang Xianxia
Published: September 2022

A decoupled unconditionally stable numerical scheme for the modified Cahn–Hilliard–Hele–Shaw system with logarithmic potential is proposed in this paper. Based on the convex-splitting of the associated energy functional, the temporal discretization of the scheme is given. The fractional step method is used to decouple the nonlinear modified Cahn–Hilliard equation from the pressure gradient. Then, at each time step, one only needs to solve Poisson’s equation which is obtained by using an incremental pressure-stabilization technique. In terms of logarithmic potential, using the regularization procedure can make the domain extended from

−
1,1

to

−
∞
,
∞

for

F

ϕ

. Finally, the proof of the energy stability and the calculation of the error estimate are presented. Numerical examples are recorded to illustrate the accuracy and performance for the proposed scheme.
Study on the Relationship between MMP-2, MMP-9 Gene Polymorphisms, and the Risk of Colorectal Cancer
Authors: Peng Su , Chen Maoliang , Wang Chunyun , Liu Changhua , Luo Kangning , Yang Lebin
Published: September 2022

Objective. The aim of the study is to explore the relationship between matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) gene polymorphisms and the risk of colorectal cancer. Methods. From January 2019 to December 2021, 308 patients with colorectal cancer in our hospital were selected to be included in the colorectal cancer group and 300 normal healthy people were included in the control group. We perform genotyping, compare the genotype frequencies between the colorectal cancer group and the control group, calculate the relationship between MMP-2 and MMP-9 gene polymorphisms and disease risk, and analyze the genotype distribution characteristics of colorectal cancer patients with different pathological stages and lymph node metastasis status. The expression levels of serum MMP-2 and MMP-9 in patients with different genotypes were compared. Results. The frequency of CC genotype and C gene at the MMP-2 gene−735 (C/T) locus in the colorectal cancer group was higher than that of the control group, and the frequency of TT genotype and T gene at MMP-9 gene−1562 (C/T) locus was a higher control group (

P
<
0.05

). The comparison of genotype and gene frequency distribution of MMP-2 gene−1306 (C/T), −790 (T/G), and MMP-9 gene R668Q and P574R between the colorectal cancer group and the control group (

P
>
0.05

); MMP-2 gene−735 (C/T) locus CC genotype and MMP-9 gene−1562 (C/T) locus TT genotype are dangerous genotypes for colorectal cancer. OR values were 1.490 (95% CI: 1.085–2.047), 1.519 (95% CI: 1.061–2.174); TNM stage III-IV, the proportion of CC genotype and TT genotype at MMP-9 gene−1562 (C/T) locus in patients with lymph node metastasis is higher than that without lymph node metastasis of TNM stage I-II patients (

P
<
0.05

); MMP-2 gene in colorectal cancer patients. Serum MMP-2 levels in patients with CC genotype at 735 (C/T) locus were higher than those with CT + TT genotype, and serum MMP-9 levels in patients with TT genotype at MMP-9 gene−1562 (C/T) locus were higher CT + CC genotype patients (

P
<
0.05

). Conclusion. The CC genotype at −735 (C/T) locus of the MMP-2 gene and the TT genotype at−1562 (C/T) locus of the MMP-9 gene are risk genotypes for the development of colorectal cancer.
MicroRNA‐34c‐5p exhibits anticancer properties in gastric cancer by targeting MAP2K1 to inhibit cell proliferation, migration, and invasion
Authors: Ma Qian , Zhao Yuan , Li Zhaojun , Gao Wenwei , Xu Yuanyi , Li Bing , Huang Yunning , Huo Zhenghao
Published: September 2022

Purpose. Gastric cancer(GC)is one of the deadliest digestive tract tumors worldwide，existing studies suggest that dysregulated expression of microRNAs (miRNAs) plays an important role in the pathogenesis and progression of GC. This study aimed to investigate the expression, biological function, and downstream mechanism of miR‐34c‐5p in GC, provide new targets for gastric cancer diagnosis and treatment. Methods. The expression of miR‐34c‐5p in GC tissues and cell lines was examined by RT‐qPCR. Cell wound healing, transwell and cell cloning assays were used to detect the effect of miR‐34c‐5p on the migration and invasion abilities, respectively, of GC cells. Western blot was performed to detect the expression of related proteins. Bioinformatics analysis was used to predict the binding of MAP2K1 to miR‐34c‐5p and the targeting relationship was confirmed by dual luciferase reporter assay. Results. The expression level of miR‐34c‐5p was significantly decreased in GC tissues and cell lines. miR‐34c‐5p overexpression inhibited migration, invasion, and colony formation of gastric cancer cells, the related protein E‐cadherin expression was significantly increased and N‐cadherin, vimentin, and PCNA expression were significantly decreased, while miR‐34c‐5p knockdown exerted the opposite effects. In addition, the targeting relationship between miR‐34c‐5p and MAP2K1 was predicted and confirmed, and further confirmed by rescue experiments that MAP2K1 alleviated the inhibitory effect of miR‐34c‐5p in GC. Conclusion. MiR‐34c‐5p is lowly expressed in GC, and it can target MAP2K1 to exert inhibitory effects on GC proliferation, invasion, and migration. These findings provide a promising biomarker and a potential therapeutic target for gastric cancer.
Forest Environmental Carrying Capacity Based on Deep Learning
Authors: Linshu Song , Hao Wang , Chao Yang , Weiming Song , Siyi Wang , Shen Wang
Published: September 2022

In this paper, we proposed an assessment system of forest environmental carrying capacity from many aspects and comprehensively evaluated and predicted the forest environmental carrying capacity of 40 cities in the Yangtze River Delta of China by using the proposed deep learning-based model. In addition, the proposed model is used to dynamically evaluate the comprehensive scores of forest environmental carrying capacity of 34 provinces and cities in China between 2015 and 2020. This paper also has the following contributions: (1) a deeply integrated unidirectional bidirectional LSTM considering the correlation of time series is proposed. The bidirectional LSTM network is used to deal with the backward dependence of input data to prevent the omission of some useful information, which is beneficial to the prediction results. (2) In terms of missing data processing, the Mask layer is added to subtly skip the processing of missing data, which will help to enhance the evaluation results.
Computational Analysis of Influencing Factors and Multiple Scoring Systems of Stone Clearance Rate after Flexible Ureteroscopic Lithotripsy
Authors: Xia Lei , Xuan Hanqing , Cao Yang , Du Zhebin , Zhong Hai , Chen Qi
Published: September 2022

Our research aims at the analysis of various stone scoring systems which are referred to as STONE scoring system (SSS) in this study. GUY’s scoring system and RUSS scoring system (RSS) are utilized to predict stone-free status (SFS) after surgery and problems after percutaneous nephrolithotomy (PCNL) for harder stones. The data of 68 patients with renal calculi who received FURL in Ren Ji Hospital from Jan 2020 to Mar 2021 are collected as the study subjects. There were 44 male and 24 female patients, with an average age of 55.6 ± 11.4 years. Reliability analysis of related influencing factors (IF) of stone clearance rate (SCR) and multiple scoring systems after flexible ureteroscopic lithotripsy (FURL) was performed. Relevant factors with statistical significance for postoperative SCR were selected for logistic regression analysis (RA). According to the SSS score, GSS classification, and RUSS score, the SCR after FURL was statistically analyzed. The results showed that the

P

values corresponding to stone position (lower caliceal), cumulative stone diameter (CSD), urinary tract infection, and external physical vibration lithecbole (EPVL) were less than 0.05. The area under the ROC curve of RUSS score, SSS score, and GSS grading was 0.932, 0.841, and 0.533, respectively. The main IF of SCR after FURL were stone location (lower caliceal), CSD, urinary tract infection, and EPVL. The RUSS score system was the best in the evaluation of SCR after FURL. In the previous research, the score systems such as CROES (CRS), SSS, S-ReS, C, and GSS for the prediction of SFS were compared. In our analysis, we have compared the RUSS scoring system which has proven to be giving better results as compared to SSS and GSS. We also performed the regression analysis and found that the stone location shows the strongest correlation of all the other factors for stone clearing rate.
[Retracted] Influence of Diversified Health Elements Based on Machine Learning Technology on Pop Vocal Singing in a Cultural Fusion Environment
Authors: Xia Han
Published: September 2022

The multicultural environment is affected by the ongoing advancement of science and technology, which results in more and more planned cultural fusions and collisions between various cultures. The emergence of distinct national cultures has emphasised cultural diversity. Music naturally takes the initiative and promotes diversity in social and cultural awareness as a cultural art form with distinctive charm. Cultural variables play a significant role in the development, appeal, and wide transmission of voice output. It is an authentic catharsis and a vivid record of spiritual activity among people. Because the diversity of art is also the source of the legacy and growth of creative innovation, the diversified integration of art will also promote the shared development of all nations. Vocal music and singing art must adapt to the circumstances, follow the trend of the times, and grow slowly and healthily in the direction of diversity in the context of multicultural development. Musical emotion is the key component of music. The periodic properties of sound should be studied since they have important implications for music study. In order to learn and predict the 8‐dimensional emotion vector of musical compositions, this study creates a dataset of 200 pieces of music, isolates music emotion detection as a regression issue, and applies machine learning techniques. According to experimental findings, when mid‐ and high‐level characteristics are used as input instead of low‐level features, accuracy can increase from 50.28% to 68.39%.
Application of Three-Dimensional (3D) Printing in Neurosurgery
Authors: Li Hao , Lu Linyun , Li Ning , Zi Liu , Wen Qian
Published: September 2022

Three-dimensional (3D) printing has been increasingly used in various fields of medicine, such as in auxiliary diagnosis and treatment, medical teaching, and regenerative medicine. Most operations performed by neurosurgeons and associated pathological examinations involve complex, microscopic anatomical structures that cannot be observed outside. 3D-printed models can reproduce anatomical structures, pathological tissues, and cells with high accuracy, enhancing our understanding of complex aspects of anatomy and pathology. They can also assist in preoperative planning and simulation, help in surgical or interventional surgery precision medicine, and improve the effectiveness of treatments. This review comprehensively summarizes and discusses its current application progress and problems, including treatments for common diseases (e.g., intracranial tumors, intracranial hemorrhage, intracranial aneurysms, skull repair, and neural prosthetics), clinical training, and preoperative plans. With its widespread applications, 3D printing as an innovative tool will provide new directions for developing imaging, strategies, and interventions in neurosurgical diseases.
New Criteria for Synchronization of Multilayer Neural Networks via Aperiodically Intermittent Control
Authors: Jing Taiyan , Zhang Daoyuan , Zhang Xiaohua
Published: September 2022

In this paper, the globally asymptotic synchronization of multi-layer neural networks is studied via aperiodically intermittent control. Due to the property of intermittent control, it is very hard to deal with the effect of time-varying delays and ascertain the control and rest widths for intermittent control. A new lemma with generalized Halanay-type inequalities are proposed first. Then, by constructing a new Lyapunov–Krasovskii functional and utilizing linear programming methods, several useful criteria are derived to ensure the multilayer neural networks achieve asymptotic synchronization. Moreover, an aperiodically intermittent control is designed, which has no direct relationship with control widths and rest widths and extends existing aperiodically intermittent control techniques, the control gains are designed by solving the linear programming. Finally, a numerical example is provided to confirm the effectiveness of the proposed theoretical results.
Detection and Correlation Analysis of Serum Uric Acid in Patients with Thyroid-Associated Ophthalmopathy
Authors: Zhou Jingbo , Yu Xu , Lou Yan , Bao Jinjing , Xia Yuequan , Zhu Lin
Published: September 2022

Purpose. To probe the property of serum uric acid in evaluating the activity of patients with thyroid-associated ophthalmopathy. Methods. A total of 443 patients with TAO admitted to our hospital from March 2016 to February 2021 were selected for the observation group. Simultaneously, 443 healthy subjects were selected for the control group. The observation group was divided into the active group (

n
=
254

) and the inactive group (

n
=
189

) according to the clinical activity score (CAS). Besides, the patients were divided into mild group (

n
=
201

), moderate severe group (

n
=
133

) and extremely severe group (

n
=
109

) based on the severity of TAO. Serum uric acid, free triiodothyronine (FT3), free thyroid hormone (FT4), thyrotropin stimulating hormone (TSH) and glycosylated hemoglobin (HbA1c) levels were detected and analyzed in each group. Results. Serum UA, FT3, FT4, TSH and HbA1c in the active group were significantly enhanced than those in the other two groups (

P
<
0.05

), and there was no significant difference between the inactive group and the control group (

P
>
0.05

). In different disease severity groups, the serum UA level of patients in the active group was significantly promoted than that in the inactive group and control group (

P
<
0.05

) and was decreased successively in extremely severe group, moderate severe group and mild group, with statistical significance (

P
<
0.05

). Pearson’s analysis showed that UA was positively correlated with FT3, FT4, and HbA1c (

r
=
0.652
,
P
=
0.031

;

r
=
0.571
,
P
=
0.042

;

r
=
0.737
,
P
=
0.024

), while was reversely correlated with TSH level (

r
=
−
0.137
,
P
=
0.262

). There was no correlation between UA and FT3, FT4, and HbA1c levels in the inactive group. UA detection showed the average sensitivity and specificity of TAO activity were 94.3% and 85.2%, respectively. There was no significant correlation between the severity of disease and serum UA in inactive patients (

P
=
0.135

). There was a positive correlation between the severity of disease and serum UA in active patients (

P
=
0.005

). Conclusion. UA may be used as a laboratory indicator for quantitative clinical diagnosis of thyroid-associated ophthalmopathy (TAO) and as a parameter for the presence of TAO activity.
SRSF3 Restriction Eases Cervical Cancer Cell Viability and Metastasis via Adjusting PI3K/AKT/mTOR Signaling Pathway
Authors: Zhang Lirong , Li Jing , Zhang Liping
Published: September 2022

Objective. To investigate the effect of SRSF3 on the viability and metastasis of cervical cancer (CC) SiHa and Hela cells. Methods. In vitro, HeLa cells and SiHa cells were cultured. In cervical cancer cells, RNA interference technology was utilized to lessen the SRSF3 level, and via RT‐PCR utilization, the SRSF3 level in every group of cells was revealed. By employing the CCK‐8 method, the OD value was revealed in every group at 24, 48, 72, and 96 h. On the migration of cervical cancer SiHa and HeLa cells via transwell utilizing, the consequence of SRSF3 was surveyed. Through western blotting utilizing, the PI3K/AKT/mTOR signaling pathway‐connected proteins levels was revealed. Results. In SiHa cells, contrasted to the NC‐SiHa group, the SRSF3 level, the number of invasive cells per unit area, the p‐PI3K/PI3K level, the p‐AKT/AKT level, and the p‐mTOR/mTOR level in the si‐SRSF3 group were substantially lessened. The OD value at 490 nm of the si‐SRSF3 group had no impressive divergence, contrasted to the NC‐SiHa group at 24 h. At 48 h, the OD value of the si‐SRSF3 group was impressively lessened than that of the NC‐SiHa group. This connection was time‐dependent. In HeLa cells, the SRSF3 level, the number of invasive cells per unit area, the level of p‐PI3K/PI3K, the level of p‐AKT/AKT, and the level of p‐mTOR/mTOR in the cells of the si‐SRSF3 group in the NC‐HeLa group were impressively lessened than those in the NC‐Hela group. Between the NC‐HeLa group and the si‐SRSF3 group at 24 h, there was no impressive divergence in the OD value at 490 nm. At 48 h, the OD value of the si‐SRSF3 group was impressively lessened than that of the NC‐SiHa group. This connection is time‐dependent. Conclusion. Reducing the SRSF3 level can restrain the viability and metastasis of cervical cancer cells via restraining the PI3K/AKT/mTOR signaling pathway.
[Retracted] Screening Tumor‐Related Genes of Gallbladder Cancer Based on AR‐Based Tumor Expression Profile Gene Chip
Authors: Guo Jia , Gong Tuotuo , Hui Beina , Zhao Xu , Li Jing
Published: September 2022

The rapid development of molecular biology and gene chip technology has produced a large amount of gene expression profile data. The main research in this article is to screen the tumor‐related genes of gallbladder cancer based on AR‐based tumor expression profile gene chip. First, convert the chip data into an expression matrix pattern that can be analyzed, and then standardize and normalize all the data. Run ReliefF, GA, and IReliefF‐GA on the data set, record the size of the feature subset, and use the tenfold cross‐validation method to obtain the classification accuracy, specificity, and sensitivity of each method on the classifier. The target genes used in the chip were amplified by PCR with the universal primers used in cDNA library construction, and the quality of PCR was monitored by agarose gel electrophoresis. The gene chip data of gallbladder cancer was processed with missing values, singular values, and so forth, and 22294 transcripts were obtained. After statistical testing, there were 9483 transcripts with statistically significant differences. The results show that as the number of clusters increases, the network can be better reconstructed through decomposition modeling.
Neutrophil to Lymphocyte Ratio and Spontaneous Bacterial Peritonitis among Cirrhotic Patients: A Systematic Review and Meta-analysis
Authors: Seyedi Seyed Arsalan , Nabipoorashrafi Seyed Ali , Hernandez Jairo , Nguyen Andrew , Lucke-Wold Brandon , Nourigheimasi Shima , Khanzadeh Shokoufeh
Published: September 2022

Background. The goal of this systematic review and meta-analysis was analyzing published studies on the role of neutrophil to lymphocyte ratio (NLR) in infection and spatially spontaneous bacterial peritonitis (SBP) among cirrhotic patients. Methods. PubMed, Web of Science, and Scopus were searched until May 24, 2022. The Newcastle–Ottawa scale was used for quality assessment. Results. Of 14 studies included in our study, six studies were on infection with 2786 hospitalized cirrhotic patients, of whom 934 developed an infection. Other studies were on SBP with 1573 cirrhotic patients with ascites, of whom 557 developed SBP. The pooled results showed that there was no difference in NLR levels between hospitalized cirrhotic patients who developed infection compared to those who did not (random-effects model: SMD = 0.63, 95% CI = −0.01–1.27,

p
=
0.054

). However, cirrhotic patients with ascites who developed SBP had elevated levels of NLR compared to those who did not (random-effects model: SMD = 1.05, 95% CI = 0.52–1.57,

p
<
0.001

). This difference remained significant in prospective studies (SMD = 0.94, 95% CI = 0.51–1.38,

p
<
0.001

) but not in retrospective studies (SMD = 1.37, 95% CI = −0.56–3.29,

p
=
0.165

), in the subgroup analysis according to the study design. The pooled sensitivity of NLR was 92.07% (95% CI = 74.85%–97.84%) and the pooled specificity was 72.58% (95% CI = 57.72%–83.69%). The pooled positive likelihood ratio, negative likelihood ratio, DOR of NLR were 3.35(95%CI = 2.06–5.46), 0.10 (95%CI = 0.03–0.38), and 30.78 (95%CI = 7.01–135.04), respectively. Conclusion. Our results support NLR to be a valid biomarker that can be readily integrated into clinical settings to help in the prevention and prediction of SBP among cirrhotic patients.
An Assessment of Accessibility and Usability of Saudi Online FinTech Services for People with Disabilities
Authors: Nour Redhwan
Published: September 2022

Innovations in financial services have given rise to Financial Technology (FinTech) as a disruptive technology which is now shaping the future of the financial sector through services like crowdfunding, peer-to-peer loans, and alternative underwriting platforms. Given the status of the web as a vital information resource, accessible and usable online FinTech services can aid people with disabilities in taking full advantage of the presented financial services to support them in basic needs like accessing high-quality care. This study set out to analyze the accessibility and usability of 32 Saudi FinTech websites by means of various automated tools and manual inspection. The results revealed the investigated websites to have a significant number of accessibility and usability problems that cause prejudice against disabled individuals and foster an overall poor user experience. Thus, more work is needed to disseminate knowledge about the importance of developing suitable FinTech websites and services to assist disabled people.
Pricing American Options by a Fourier Transform Multinomial Tree in a Conic Market
Authors: Wang Weiwei , Hu Xiaoping
Published: September 2022

Based on FFT, a high‐order multinomial tree is constructed, and the method to obtain the price of American style options in the Lévy conic market is studied. Firstly, the nature of the Lévy process and the pricing principle of European‐style options are introduced. Secondly, the method to construct a high‐order multinomial tree based on Fourier transform is presented. It can be proved by theoretical derivation that the multinomial tree can converge to the Lévy process. Thirdly, we introduce the conic market theory based on the concave distortion function and give the discretization method of the concave distortion expectation. Then, the American option pricing method based on reverse iteration is given. Finally, the CGMY process is used to demonstrate how to price the American put option in the Lévy conic market. We can draw conclusions that the Fourier transform multinomial tree can avoid the difficulty of parameter estimation when using traditional moment matching methods to construct multinomial trees. Because the Lévy process has the analytic form characteristic function, this method is a promising method to calculate the prices of options in the Lévy conic market.
Sex Differences in the Association of Sibship Size and Position in Sibship with Lipid Profile during Adolescence: A Cross-Sectional Study
Authors: Ziyab Ali H. , Almari Mohammad , Mohammad Anwar , Al-Taiar Abdullah , Karmaus Wilfried
Published: September 2022

Background. Epidemiologic studies have reported associations of sibship size and position of the child in the sibship with multiple health outcomes, including adiposity and diabetes. However, little is known about sibling effects on lipids. Hence, this study sought to evaluate associations of the number of total, older, and younger siblings with lipid profile among adolescents. Methods. In a cross-sectional study among high school students aged 14 to 19 years, lipid levels were measured in capillary blood. Parents reported the number of siblings (total, older, and younger). Geometric means of lipids were calculated, and linear regression was used to estimate the ratio of geometric means (RoGM) and 95% confidence intervals (CI). Analyses were sex stratified. Results. Of the total study sample (n = 1,584), 758 (47.9%) were boys and 826 (52.1%) were girls, with median age of 16.0 years. Total cholesterol (TC) was lower by 8% (adjusted-RoGM = 0.92, 95% CI: 0.88–0.96) among boys with ≥3 older siblings compared to those with no older siblings. Similarly, boys with ≥3 younger sibling compared to those with no younger siblings had reduced TC by 7% (adjusted-RoGM = 0.93, 0.87–0.99). Moreover, an increased number of total siblings (≥4 vs. 0/1: adjusted-RoGM = 0.80, 0.67–97) and older siblings (≥3 vs. 0: adjusted-RoGM = 0.90, 0.82–0.98) were associated with reduced low-density lipoprotein cholesterol (LDL-C) among boys. Similarly, lower levels of triglycerides (TG) were seen among boys with ≥3 older siblings compared to those with no older siblings (adjusted-RoGM = 0.87, 0.78–0.96). A higher number of younger siblings was associated with increased high-density lipoprotein cholesterol (HDL-C) among boys (≥3 vs. 0: adjusted-RoGM = 1.08, 1.01–1.17). Sibship characteristics were not associated with lipids among girls. Conclusions. Increased number of total, older, and younger siblings were associated with favorable lipid profiles among adolescent boys, but not girls. Mechanisms underlying these associations need further investigations.
In Vitro Bulbification of Five Lily Varieties: An Effective Method to Produce Quality Seeds and Flowers
Authors: Lapiz-Culqui Yoiner K. , Meléndez-Mori Jegnes Benjamín , Mállap-Detquizán Gerardo , Tejada-Alvarado José Jesús , Vilca-Valqui Nuri Carito , Huaman-Human Eyner , Oliva Manuel , Goñas Malluri
Published: September 2022

Lilies are one of the most important, beautiful, and economically valuable flowers in the world. Lilium is regarded as a popular floral trade cut flower, so viable protocols are needed to provide seed production, multiplication, and preservation. In vitro protocols allow for rapid large-scale production and rejuvenation of planting material, but to be a commercially viable multiplication method, the procedure must allow for rapid production of viable, true-to-type plants quickly. The objective was to evaluate the in vitro production of microbulbs of five lily varieties (Lilium “Champion Diamond,” Lilium “Yellow Diamond,” Lilium “Batavus,” Lilium “Hyde Park,” and Lilium sp.) using different concentrations of 6-benzylaminopurine (0, 0.5, 1.0, 1.5, 1.5, and 2.0 mg L−1 BAP) and to determine the commercial quality (flowering) of the plants grown from the seed obtained. Results from the micropropagation phase show Lilium “Batavus” and Lilium “Hyde Park” varieties had better in vitro responses, especially when grown with 1.0 and 1.5 mg L−1 BAP, respectively. Plants (of all varieties) grown from microbulbs showed positive growth and generally resulted in commercially viable flower production. Finally, the results of this study support the use of bulb scales as an alternative for obtaining vegetative seeds with high potential for lily cultivation.
Nasopharyngeal Wash with Normal Saline Decreases SARS-CoV-2 Viral Load: A Randomized Pilot Controlled Trial
Authors: Pantazopoulos I. , Chalkias A. , Mavrovounis G. , Dimeas I. , Sinis S. , Miziou A. , Rouka E. , Poulas K. , Gourgoulianis K.
Published: September 2022

Background. Although great progress has been made over the past 2 years in the scientific understanding of the biology, epidemiology, and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), case morbidity and fatality rates remain a great concern and continue to challenge the healthcare resources worldwide as novel variants emerge. There is therefore an urgent need for affordable and readily available strategies to reduce viral transmission. Previous studies in non-COVID-19 patients have demonstrated that administration of low-salt (isotonic but 0.0375% Na) and isotonic saline (0.9% Na) solutions has been associated with an immediate, significant reduction in the microbial antigens and a related decline of microbial burden. The aim of the present study was to determine the effect of nasal washes with normal saline 0.9% on nasopharyngeal viral load and outcome in hospitalized patients with COVID-19 pneumonia. Methods. We performed a prospective, randomized, pilot, controlled trial in 50 patients with confirmed COVID-19 disease. Patients were randomized into two groups, the normal saline group (received normal saline 0.9% solution for nasopharyngeal wash) and the control group (no treatment). In the normal saline group, nasopharyngeal wash was performed every 4 hours for a 16-hour period. Twenty-four hours after the baseline nasopharyngeal swab (and 8 hours after the last wash in the normal saline group), a second nasopharyngeal swab was collected for the semiquantitative estimation of the SARS-CoV-2 viral load as determined by cycle threshold (Ct) values. Results. In the normal saline group, mean N gene Ct values increased significantly 24 hours after the baseline measurement [ΔCtday2−day1 = 1.87 ± 3.11 cycles,

p
=
0.007

(95% CI: 0.55 to 3.18)], indicating a decline in SARS-CoV-2 nasopharyngeal viral load by 8.9%. A significant decrease in mean N gene Ct values was observed in the control group, indicating an increase in viral load [ΔCtday2-day1 = −2.12 ± 2.66,

p
<
0.001

(95% CI: −3.20 to −1.05)] by 9.7%. The difference between the two groups 24 hours after admission and nasopharyngeal wash was 3.09 cycles (

p
=
0.005

, 95% CI: 0.97 to 5.20). Conclusion. Nasal washes with normal saline effectively decreased the viral load during hospitalization and at follow-up.
Universal Minimal Model for Glucose-Insulin Relationship with the Influence of Food Dynamic
Authors: Kumnungkit Kanchana , Likasiri Chulin , Pongvuthithum Radom , Tantakitti Faifan
Published: September 2022

We propose a minimal model defining the relationship between glucose and insulin with the added influence of food intakes. The constructed model consists of a system of 3 nonlinear ordinary differential equations (ODEs). The solutions of our model for both normal and diabetic subjects are compared with a minimal model and a maximal model representing the same relationship. We found that the outputs of our model are similar to those from the minimal and maximal models for both normal and diabetic subjects; the

R

2

are 0.9997 and 0.9922, respectively, when compared with the minimal model, and are 0.9995 and 0.9940, respectively, when compared with the maximal model. Moreover, the relative errors between solutions are at most 0.9035% and as low as

1.488
×

10

−
2

%

on average when compared with the minimal model for normal subjects and at most 1.331% and as low as 0.1159% on average for diabetic subjects. The discrepancy between our model and the maximal model are at most 1.590% and 5.453% for normal and diabetic subjects, respectively, with a relative error averaging 0.2138% and 0.9002% for normal and diabetic subjects, respectively.
Research on Basic Wind Pressure Calculation Method for Lacking Long‐Term Wind Speed Data
Authors: Wang Bo , Shang Weining , Dong Lixin , Dong Yuanzheng
Published: September 2022

In engineering structural design, wind load is of particular importance, and the basic wind pressure is the basis for wind load calculation. Specifications of many countries fail to use the given method to calculate the basic wind pressure for areas or engineering projects with only short‐term wind speed data. At the same time, there are few studies on short‐term wind speed data fitting by using the extreme value Type III distribution as the distribution law. In this study, the extreme value Type III distribution with variable substitution method and least square method as parameter estimation method is used to fit and analyze the daily, weekly, and monthly maximum wind speed data of 13 major cities in China, when using the Kolmogorov–Smirnov test method to test the results of the fit, it finds that in the wind speed samples of most cities, only the monthly maximum wind speed data obeys the extreme value Type III distribution. By comparing the optimal criterion of estimation, it can be seen that the extreme value Type III distribution fits well with the monthly maximum wind speed data of each city, and the variable substitution method is the most optimal parameter estimation method. The above results show that in areas where long‐term wind speed data are insufficient, short‐term wind speed data is an available option. Taking the extreme value Type III distribution as the probability distribution, the method of calculating the basic wind pressure of different return periods based on short‐term wind speed data is summarized by comparing the specifications of various countries in the world.
Soft Relations Applied to the Substructures of Quantale Module and Their Approximation
Authors: Qurashi Saqib Mazher , Gilani Khushboo Zahra , Shabir Muhammad , Gulzar Muhammad , Alam Ashraful
Published: September 2022

This research article offers a study on a new relation of rough sets and soft sets with an algebraic structure quantale module by using soft reflexive and soft compatible relations. The lower approximation and upper approximation of subsets of quantale module are utilized by aftersets and foresets. As a sequel of this relation, different characterizations of rough soft substructures of quantale modules are obtained. To ensure the results, soft reflective and soft compatible relations are focused and these are interpreted by aftersets and foresets. Furthermore, the algebraic relations between upper (lower) approximation of substructures of quantale module and the upper (lower) approximations of their homomorphic images with the help of quantale module homomorphism are examined. In comparison with the different type of approximations in different type of algebraic structures, it is concluded that this new study is much better.
Component-Effect Relationship between HPLC Fingerprints and Lipid-Lowering Activity of Buyang Huanwu Decoction
Authors: Li Lijing , Zhou Kaixuan , Zhao Qiulu , Wang Yuejie , Liu Jia , Bao Huiwei
Published: September 2022

Buyang Huanwu Decoction (BHD) has lipid-lowering and antioxidant effects. In this study, HPLC was used to establish the fingerprint of extracts from different polar parts of BHD. Through the L02 cell lipid deposition model induced by oleic acid, extracts from different polar parts of BHD were administered for treatment. Oil red O staining, TG detection, and MDA detection were used to determine lipid deposition and antioxidant activity. The component-effect relationship is established by using grey relational analysis and PLSR analysis. The results showed that the extracts from different polar parts of BHD could reduce the levels of TG and MDA. The grey relational analysis showed that the peaks that contributed greatly to the reduction of TG and MDA were peaks 3, 16, 14, 10, 1, 15, 2, and 11, respectively. Peaks 1, 4, 9, 10, 14, 16, and 17 could reduce TG and MDA through PLSR analysis. According to the results of grey relational analysis and PLSR analysis, peaks 1, 10, 14, and 16 may have good lipid-lowering and antioxidant effects. This study provides a certain preliminary basis for follow-up research on lipid-lowering drugs.
[Retracted] Design and Implementation of Balance Ability Assessment Training System for Special Children Based on Education Cloud Integration
Authors: Lu Yan , Xing Mingming , Song Jian
Published: September 2022

Many children with special needs have body balance disorders, which will not only bring inconvenience to their daily lives but also have a certain impact on their spirits, making them insecure. It will lead to a decline in their social skills, which will also seriously affect their study and work as well as reduce their quality of life. The purpose of this paper is to design and discuss a system for evaluating and training the balance ability of children with special needs based on the integration of education cloud. The balance ability evaluation module of the system performs a series of calculations on the projection coordinates of the center of gravity of the human body in various postures, and the obtained parameter values are the basis of the evaluation. This paper analyzes the role of education cloud integration in the evaluation of balance ability of special children, evaluates and trains the balance ability of special children, and verifies the feasibility of the balance ability evaluation and training system for special children. This study found that in a feasibility trial evaluating the balance ability of children with special needs, the balance stability of the tested children was improved, and the overall balance ability improved by 60%. The balance ability evaluation training system developed in this paper can effectively improve the independent standing ability of young children. Children over the age of 4 do not have any difficulties in understanding and mastering movements, and training difficulties for children are also applicable. At the same time, the results of these exercises also showed that this kind of exercise can help children maintain their balance.