bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of the p3-VvAGL11 Marker for Stenospermocarpic Seedlessness in Euvitis × Muscadinia Grape Hybrid Progenies
Authors: Conner Patrick J. , Gunawan Gunawati , Clark John R.
Published: July 2018

Stenospermocarpic seedlessness from Vitis vinifera L. is being introgressed into muscadine grape (Vitis rotundifolia Michx.) germplasm through the use of a cross-fertile hybrid of the two species. Recently, a sequence-tagged site (STS) molecular marker, p3_VvAGL11, has been developed which enables detection of the dominant allele controlling stenospermocarpic seedlessness in V. vinifera. This marker was evaluated in six Euvitis Planch. × Muscadinia Planch. hybrid progenies to determine its association with seedlessness in this material. The presence of the 214-bp seedlessness-associated p3_VvAGL11 allele in seedling vines resulted in a nearly 3-fold reduction in mean seed fresh weight (MSFW) and significantly reduced mean seed weight per berry (MSWB), percent berry weight composed of seed (BWCS), and mean berry weight (MBW). When the lack of lignified seed was used as the determinant of seedlessness, the p3_VvAGL11 marker was able to correctly judge seedlessness in ≈85% of the progeny. Analysis of seedlessness in the progenies was hampered by poor vigor and fruiting ability of the hybrid seedlings. The p3_VvAGL11 marker shows potential to speed the introduction of the stenospermocarpic seedlessness into Muscadinia germplasm by identifying seedless progeny at the seedling stage.
KOKU DUYUSUNUN DİĞER DUYULARDAN FARKI VE FARKLILIĞIN EVRİMSEL PERSPEKTİFLE DEĞERLENDİRİLMESİ
Authors: ÜNVER FİDAN Reyhan
Published: July 2018

Düşük enerjiyle
verimli bilgi edinme işlemi bilginin bilinç gerektirmeyen kanallardan elde
edilmesine işaret etmektedir. Bilinç bilgi işlemede hem verimlilik elde etme
hem de problem çözme becerisi için her zaman üstün bir araç değildir. Verimli
bilgi edinme işlemi bilginin bilinç gerektirmeden hızla anlam bulmasını
kolaylaştırmaktadır. Özellikle hayatta kalmaya yardımcı olacak kritik bilgileri
seçerek belleğe daha güçlü şekilde kaydetmekte ve organizma hayati önem taşıyan
bilgiye hızla cevap verebilmektedir. Diğer duyularla karşılaştırıldığında koku
sistemi üst bilişle doğrudan bağlantıları sayesinde çevre hakkında bilgi
toplamak için daha ekonomik bir olanak sunmaktadır. Bu bağlamda koku alma
sürecine aracılık eden nöral yollar ve mekanizmalar diğer duyu sistemlerinin
anatomik organizasyonundan oldukça farklılık göstermektedir. Yapılan
araştırmalar koku, duygu ve hafıza arasındaki bağlantıyı ortaya koyan
davranışsal bulgular ile koku duyusunu diğer duyulardan ayrıştıran sinirsel
bağlantılarını gösteren nöro-görüntülerin örtüştüğünü göstermektedir. Bu
çalışma koku duyusunun özelleşmiş anatomik yapısı ile insan davranışları
üzerindeki etkisini ve işlevini evrimsel perspektifle değerlendirmek amacıyla
hazırlanmıştır.
Evaluation and management of forest water conservation services – taking Zhalantun City in Inner Mongolia, China as an example
Authors: Zhang Ying , Zhang Yining
Published: July 2018

Forests play a key role in water conservation. Based on official statistics and field surveys, this paper uses the indirect market evaluation method (IMEM), and especially the water balance method (WBM), to assess the quantity and value of forest water conservation in 2016 in Zhalantun City in Inner Mongolia, China. The results indicate that the value of forest water conservation in Zhalantun is RMB 15.085 billion yuan (RMB is an abbreviated form of ‘Renminbi’, which stands for currency of People's Republic of China. It's primary unit is the yuan), which accounts for 80% of gross domestic product (GDP), and which is 3.74 times the added value of the primary industry, and 1.56 and 2.96 times the added value of the secondary and tertiary industries, respectively, in the same year. The paper also discusses some related issues and points out that the negative effects should also be considered and calculated when using the WBM to evaluate forest water conservation services, and forest water conservation services management and environmental statistics should be established in advance to better serve management planning and policy making.
Sorption of Ni(II) on surface of bed grains used in iron and manganese removal filters
Authors: Tytkowska Marta , Michel Magdalena M. , Reczek Lidia , Siwiec Tadeusz
Published: July 2018

This paper reports the results of determinations of crystalline phase type, specific surface area, point of zero charge pH (pHpzc), and Ni(II) sorption capacities of beds for groundwater treatment. Bed materials from iron and manganese removal filters (FeRF, MnRF) as well as a catalytic bed (G1) were investigated. The reference material was MnO2-coated quartz sand (MnQS). The efficiency of Ni(II) sorption was investigated as a function of pH. It was found that the naturally formed coating on FeRF was characterised by the highest sorption efficiency (80–88%) in the wide pH range (4–9) of the solution. Sorption on MnRF was weaker (35–45%). G1 and MnQS, which contained only manganese oxides, were characterised by a very low sorption efficiency of 0–6% and 3–8%, respectively. A lower Ni(II) removal efficiency was observed at an initial pH close to the pHpzc values. During Ni(II) sorption, the pH of the solution was not constant and tended towards the value of pHpzc for all tested materials. The slightly pH-dependent sorption of Ni(II) indicates that its removal depends more on the chemical composition and the specific surface area of the oxide coatings covering the bed materials.
Oral evaluation of children and adolescents in intensive care unit
Authors: Schunemann Fernanda Haverroth , Canani Soraia Hopfner , Marín Constanza
Published: July 2018

Introduction: Hospitalized children can present some complications if they do not present a correct oral care during hospitalization. Objective: This study aimed to perform an oral evaluation of children and adolescents hospitalized in an intensive care unit of a children’s hospital at southern Brazil. Material and methods: 49 subjects were examined, aged from 0 to 17 years old, using themodified Oral Assessment Guide (OAGm). The lips, corner of the mouth, gums, oral mucosa, saliva, tongue, and teeth were examined. Each category was classified in a numeric scale from 1 to 3, where 1 means the better condition and 3 the worse. Results: The results showed alterations in the lips, tongue, oral biofilm, and saliva in most of the subjects. The OAGm value indicated a worse oral condition in older children. The OAGm values for children with teeth were higher than that for edentulous children, this difference was statistically significant (p<0.05). Conclusion: It could be concluded that children hospitalized in an intensive care unit show deficiency in oral health when assessed through OAGm.
Evaluation of anthropometric facial landmarks in woman with Blepharophimosis, Ptosis, and Epicanthus Inversus Syndrome (BPES)
Authors: Dering Lorena Maria , Saade Marina , Ferreira Juliana De Cassia Pinto , Pereira Vivian Monteiro , Rechia Bruna Cristina do Nascimento , Veronez Djanira Aparecida da Luz , Torres Maria Fernanda Pioli , Fregoneze Andréa Paula , Brancher João Armando
Published: July 2018

Introduction: Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) is a syndrome easily recognized by facial appearance. In this sense, the facial anthropometry is a simple and non-invasive way to evaluate the morphology of the facial surface of individuals, thus, defining the craniofacial dimensions. Objective: To evaluate the facial anthropometric measurements of a Caucasian female, aged 20 years, diagnosed with BPES and to compare these measures with the values described in the literature for non-syndromic woman.Material and methods: This research is an observational study of a Caucasian female, aged 20 years, who was diagnosed with BPES. Frontal photographs were taken, and the images analyzed by nine researchers calibrated in Image J® software. The facial measurements evaluated were head, face, orbits, nose, and labio-oral region and were compared with non-syndromic woman. Results: All vertical and horizontal face measurements were higher than that of otherfemales from Caucasian groups. BPES woman also presented bilateral ptosis and the main differences appear in the region of the orbits. Conclusion: The anthropometric facial analysis of BPES woman showed a significant change in the facial landmarks.
Comparative analysis of reflection photoelasticity in mandible’s segment with or without base
Authors: Filho Humberto Gennari , Mazaro José Vitor Quineli , Goiato Marcelo Coelho , Turcio Karina Helga Leal , Amoroso Andressa Paschoal , Antenucci Rosse Mary Falcón
Published: July 2018

Introduction and Objective: To analyze if axial loads of 50 N and 100 N, applied on an implant of 3.75 X 10 mm (Conexão-Jaú, SP, Brazil) fixed on the central portion of a prototype of the mandible with and without support base, generate isochromatic fringes of different intensity and ways. Material and methods: The sample was a segment of the mandible with 115 mm in length, 30 mm height,and 12 mm in thickness, from a block of #7 rose wax. This matrix was adapted to a modified articulator in such way that its base could or not keep contact with the lower arm of the articulator, simply by modifying the support axis. An implant was put perpendicular to the segment of the mandible’s body and then the photoelastic model obtained. The healing abutment was screwed to the implant to receive loads from 50 N to 100 N, with the model with or withoutcontact of its base with the inferior arm of the articulator. Results: Alterations in the reflections of the colors was observed when the implants had been submitted to loads of 50 N and 100 N with or without supported base. Conclusion: Based on the results, it can be concluded that during the photoelasticity analyses alterations in the color standards occurred depending on the support of the sample and the applied load.
Prevalence of dental caries in 5 and 12-years-old schoolchildren from two Brazilian capitals
Authors: Moura Claudia Roberta de Mello , Pizzatto Eduardo , Brancher João Armando , Koch Luiza Foltran de Azevedo , Zortéa Cristiano , Gabardo Marilisa Carneiro Leão , Bruzamolin Carolina Dea
Published: July 2018

Introduction: Tooth decay is still a highly prevalent disease in populations. Because of this, epidemiological studies are carried out frequently and allow the monitoring of the experience of the disease. Objective: To estimate the prevalence of dental caries of 5 and 12-years-old schoolchildren in the cities of Florianópolis, Santa Catarina, and Porto Velho, Rondônia, as well as to searchhypotheses of association with social/economic determinants and access to dental services. Material and methods: Secondary data were used from the Brazilian Oral Health Survey of 2010, as follows: household income by city and dmft/DMFT index for ages by city and region of Brazil. Results: It was observed in the city of Florianópolis a 5-years-old dmft of 1.56, and 12-years-oldDMFT of 0.55. In Porto Velho the means were 2.89 and 4.15 to the respective age. It was found that in Porto Velho 89.5% of surveyed had family income up to R$2,500.00, while in Florianópolis 81.9% had R$501.00 to R$9,500.00. Conclusion: The city of Florianópolis had the best caries indices and socioeconomic conditions, suggesting an association between these variables, in detriment to the regions in the opposite situation.
Critical analysis of methodologies for valuation of esthetic damage and the forensic application in Brazil
Authors: Vetter Flávia , Pereira Rodrigo Torres , Block Lilian Lígia , Zaitter Wellington Menyrval , Oliveira Rogério Nogueira de , Fernandes Mário Marques
Published: July 2018

Introduction: The esthetic damage is any pejorative modification in static or dynamic expression, perceived by any sense, affecting the image of the person. The esthetic damage repair has legal support in Brazilian legislation. Objective: to systematize the different existing methods for valuation of esthetic damages, critically analyze their characteristics, advantages and disadvantages; and evaluate whether these methods would have been validated in any population inside or outside of Brazil. Literature review: The adoption of the use of tables, formulas and coefficients was insufficient to overcome the limitations of each method, such as those supported by the measurement of a single scar or by the teeth. Conclusion: All available subjective methods, except for AIEL method did not havescientific evidence, lacking validation in any country, and requiring proof of methodology.
Epidemiological survey in oral health of the residents of the Teixeira Island, Paraná, Brazil
Authors: Suizani Tiago Rodrigues , Mello Bruna Leal de , Koch Luiza Foltran De Azevedo , Bruzamolin Carolina Dea , Gabardo Marilisa Carneiro Leão
Published: July 2018

Introduction: The epidemiological surveys aim to evaluate the distribution and state determinants or events in health in given populations. Objective: To conduct an epidemiological survey on the socioeconomic condition, use of dental services, referred oral morbidity, self-perception, and oral health of inhabitants of the Teixeira Island, Paraná, Brazil. Material and methods: The studyfollowed the statements of the World Health Organization and the Brazilian National Epidemiological Survey (SB Brazil 2010). Questionnaires were applied, and in the clinical examination the following data were collected: dental trauma, edentulism, fluorosis, caries in deciduous teeth (dmft), caries in permanent teeth (DMFT), Community Periodontal Index (CPI) and Loss of Periodontal Insertion Index (LPII). The data were analyzed with Statistical Package for Social Sciences software, version 21.0, and expresses in frequency tables. Results: Of the 108 inhabitants, 90 participated in the study. The socioeconomics conditions unfavorable were: low income and low schooling. The water supplying was not fluoridated. The perception of oral problems was reported by 82.2%; 48.9% declared to have had toothache in last the six months; the reason of search for care was predominantly for curative treatments. Almost 30% of the participants declared to be unsatisfied with their oral health. The  values of DMFT and dmtf indexes were 13.9 and 1.2, respectively. The greater demand for maxillary prosthesis occurred in 39.7% of the sample, while 34.2% needed mandibular prosthesis. Conclusion: The oral diseases illnesses and need of treatment were evidenced in the sample, as well as risk factors that deserve attention of the public power.
Focal Adhesion Kinase in Ovarian Cancer: A Potential Therapeutic Target for Platinum and Taxane-Resistant Tumors
Authors: Levy Arkene , Alhazzani Khalid , Dondapati Priya , Alaseem Ali , Cheema Khadijah , Thallapureddy Keerthi , Kaur Paramjot , Alobid Saad , Rathinavelu Appu
Published: July 2018

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase, which is an essential player in regulating cell migration, invasion, adhesion, proliferation, and survival. Its overexpression and activation have been identified in sixty-eight percent of epithelial ovarian cancer patients and this is significantly associated with higher tumor stage, metastasis, and shorter overall survival of these patients. Most recently, a new role has emerged for FAK in promoting resistance to taxane and platinum-based therapy in ovarian and other cancers. The development of resistance is a complex network of molecular processes that make the identification of a targetable biomarker in platinum and taxane-resistant ovarian cancer a major challenge. FAK overexpression upregulates ALDH and XIAP activity in platinum-resistant and increases CD44, YB1, and MDR-1 activity in taxaneresistant tumors. FAK is therefore now emerging as a prognostically significant candidate in this regard, with mounting evidence from recent successes in preclinical and clinical trials using small molecule FAK inhibitors. This review will summarize the significance and function of FAK in ovarian cancer, and its emerging role in chemotherapeutic resistance. We will discuss the current status of FAK inhibitors in ovarian cancers, their therapeutic competencies and limitations, and further propose that the combination of FAK inhibitors with platinum and taxane-based therapies could be an efficacious approach in chemotherapeutic resistant disease.
Role of C1858T Polymorphism of Lymphoid Tyrosine Phosphatase in Egyptian Children and Adolescents with Type 1 Diabetes
Authors: El Fotoh Wafaa Moustafa M. Abo , El Razek Midan Dina Abd , El Shalakany Abeer Hamdy
Published: July 2018

Background:

Type 1 Diabetes Mellitus (T1DM) is a multifactorial autoimmune disease. The
Protein Tyrosine Phosphatase Non-receptor 22 (PTPN22) gene is an important negative regulator of
signal transduction through the T-cell Receptors (TCR). A PTPN22 polymorphism, C1858T, has been
found to be a risk determinant for several autoimmune diseases, including T1DM, in different populations.

Objective:

The present study was aimed to analyze a possible association between the C1858T polymorphism
in Egyptian children with T1DM.

Methods:

This case-control study included 240 children divided evenly between T1DM patients and
controls. The PTPN22 C1858T polymorphism was genotyped using polymerase chain reaction with
Restriction Fragment Length Polymorphism (RFLP).

Results:

Both the 1858CΤ and 1858ΤΤ genotypes and the 1858T allele were found more frequently in
patients (32.5% and 18.7%, respectively) than in controls (10% and 5.0%, respectively), P=0.013 and
P=0.007, respectively. Among females, the 1858T allele was more common in patients (18%) than in
controls (2.6%), P=0.014.

Conclusion:

These findings suggest that the PTPN22 1858T allele could be a T1DM susceptibility factor
in the Egyptian population and that it might play a different role in susceptibility to T1DM according
to gender in T1DM patients.
Patient Judgments About Hypertension Control: The Role of Variability, Trends, and Outliers in Visualized Blood Pressure Data (Preprint)
Authors: Shaffer Victoria Anne , Wegier Pete , Valentine KD , Belden Jeffery L , Canfield Shannon M , Patil Sonal J , Popescu Mihail , Steege Linsey M , Jain Akshay , Koopman Richelle J
Published: July 2018

BACKGROUND

Uncontrolled hypertension is a significant health problem in the United States, even though multiple drugs exist to effectively treat this chronic disease.

OBJECTIVE

As part of a larger project developing data visualizations to support shared decision making about hypertension treatment, we conducted a series of studies to understand how perceptions of hypertension control were impacted by data variations inherent in the visualization of blood pressure (BP) data.

METHODS

In 3 Web studies, participants (internet sample of patients with hypertension) reviewed a series of vignettes depicting patients with hypertension; each vignette included a graph of a patient’s BP. We examined how data visualizations that varied by BP mean and SD (Study 1), the pattern of change over time (Study 2), and the presence of extreme values (Study 3) affected patients’ judgments about hypertension control and the need for a medication change.

RESULTS

Participants’ judgments about hypertension control were significantly influenced by BP mean and SD (Study 1), data trends (whether BP was increasing or decreasing over time—Study 2), and extreme values (ie, outliers—Study 3).

CONCLUSIONS

Patients’ judgment about hypertension control is influenced both by factors that are important predictors of hypertension related-health outcomes (eg, BP mean) and factors that are not (eg, variability and outliers). This study highlights the importance of developing data visualizations that direct attention toward clinically meaningful information.
Measuring Free-Living Physical Activity With Three Commercially Available Activity Monitors for Telemonitoring Purposes: Validation Study (Preprint)
Authors: Breteler Martine JM , Janssen Joris H , Spiering Wilko , Kalkman Cor J , van Solinge Wouter W , Dohmen Daan AJ
Published: July 2018

BACKGROUND

Remote monitoring of physical activity in patients with chronic conditions could be useful to offer care professionals real-time assessment of their patient’s daily activity pattern to adjust appropriate treatment. However, the validity of commercially available activity trackers that can be used for telemonitoring purposes is limited.

OBJECTIVE

The purpose of this study was to test usability and determine the validity of 3 consumer-level activity trackers as a measure of free-living activity.

METHODS

A usability evaluation (study 1) and validation study (study 2) were conducted. In study 1, 10 individuals wore one activity tracker for a period of 30 days and filled in a questionnaire on ease of use and wearability. In study 2, we validated three selected activity trackers (Apple Watch, Misfit Shine, and iHealth Edge) and a fourth pedometer (Yamax Digiwalker) against the reference standard (Actigraph GT3X) in 30 healthy participants for 72 hours. Outcome measures were 95% limits of agreement (LoA) and bias (Bland-Altman analysis). Furthermore, median absolute differences (MAD) were calculated. Correction for bias was estimated and validated using leave-one-out cross validation.

RESULTS

Usability evaluation of study 1 showed that iHealth Edge and Apple Watch were more comfortable to wear as compared with the Misfit Flash. Therefore, the Misfit Flash was replaced by Misfit Shine in study 2. During study 2, the total number of steps of the reference standard was 21,527 (interquartile range, IQR 17,475-24,809). Bias and LoA for number of steps from the Apple Watch and iHealth Edge were 968 (IQR −5478 to 7414) and 2021 (IQR −4994 to 9036) steps. For Misfit Shine and Yamax Digiwalker, bias was −1874 and 2004, both with wide LoA of (13,869 to 10,121) and (−10,932 to 14,940) steps, respectively. The Apple Watch noted the smallest MAD of 7.7% with the Actigraph, whereas the Yamax Digiwalker noted the highest MAD (20.3%). After leave-one-out cross validation, accuracy estimates of MAD of the iHealth Edge and Misfit Shine were within acceptable limits with 10.7% and 11.3%, respectively.

CONCLUSIONS

Overall, the Apple Watch and iHealth Edge were positively evaluated after wearing. Validity varied widely between devices, with the Apple Watch being the most accurate and Yamax Digiwalker the least accurate for step count in free-living conditions. The iHealth Edge underestimates number of steps but can be considered reliable for activity monitoring after correction for bias. Misfit Shine overestimated number of steps and cannot be considered suitable for step count because of the low agreement. Future studies should focus on the added value of remotely monitoring activity patterns over time in chronic patients.
The mHealth App Usability Questionnaire (MAUQ): Development and Validation Study (Preprint)
Authors: Zhou Leming , Bao Jie , Setiawan I Made Agus , Saptono Andi , Parmanto Bambang
Published: July 2018

BACKGROUND

After a mobile health (mHealth) app is created, an important step is to evaluate the usability of the app before it is released to the public. There are multiple ways of conducting a usability study, one of which is collecting target users’ feedback with a usability questionnaire. Different groups have used different questionnaires for mHealth app usability evaluation: The commonly used questionnaires are the System Usability Scale (SUS) and Post-Study System Usability Questionnaire (PSSUQ). However, the SUS and PSSUQ were not designed to evaluate the usability of mHealth apps. Self-written questionnaires are also commonly used for evaluation of mHealth app usability but they have not been validated.

OBJECTIVE

The goal of this project was to develop and validate a new mHealth app usability questionnaire.

METHODS

An mHealth app usability questionnaire (MAUQ) was designed by the research team based on a number of existing questionnaires used in previous mobile app usability studies, especially the well-validated questionnaires. MAUQ, SUS, and PSSUQ were then used to evaluate the usability of two mHealth apps: an interactive mHealth app and a standalone mHealth app. The reliability and validity of the new questionnaire were evaluated. The correlation coefficients among MAUQ, SUS, and PSSUQ were calculated.

RESULTS

In this study, 128 study participants provided responses to the questionnaire statements. Psychometric analysis indicated that the MAUQ has three subscales and their internal consistency reliability is high. The relevant subscales correlated well with the subscales of the PSSUQ. The overall scale also strongly correlated with the PSSUQ and SUS. Four versions of the MAUQ were created in relation to the type of app (interactive or standalone) and target user of the app (patient or provider). A website has been created to make it convenient for mHealth app developers to use this new questionnaire in order to assess the usability of their mHealth apps.

CONCLUSIONS

The newly created mHealth app usability questionnaire—MAUQ—has the reliability and validity required to assess mHealth app usability.
Novel Approach to Inpatient Fall Risk Prediction and Its Cross-Site Validation Using Time-Variant Data (Preprint)
Authors: Cho Insook , Boo Eun-Hee , Chung Eunja , Bates David W. , Dykes Patricia
Published: July 2018

BACKGROUND

Electronic medical records (EMRs) contain a considerable amount of information about patients. The rapid adoption of EMRs and the integration of nursing data into clinical repositories have made large quantities of clinical data available for both clinical practice and research.

OBJECTIVE

In this study, we aimed to investigate whether readily available longitudinal EMR data including nursing records could be utilized to compute the risk of inpatient falls and to assess their accuracy compared with existing fall risk assessment tools.

METHODS

We used 2 study cohorts from 2 tertiary hospitals, located near Seoul, South Korea, with different EMR systems. The modeling cohort included 14,307 admissions (122,179 hospital days), and the validation cohort comprised 21,172 admissions (175,592 hospital days) from each of 6 nursing units. A probabilistic Bayesian network model was used, and patient data were divided into windows with a length of 24 hours. In addition, data on existing fall risk assessment tools, nursing processes, Korean Patient Classification System groups, and medications and administration data were used as model parameters. Model evaluation metrics were averaged using 10-fold cross-validation.

RESULTS

The initial model showed an error rate of 11.7% and a spherical payoff of 0.91 with a c-statistic of 0.96, which represent far superior performance compared with that for the existing fall risk assessment tool (c-statistic=0.69). The cross-site validation revealed an error rate of 4.87% and a spherical payoff of 0.96 with a c-statistic of 0.99 compared with a c-statistic of 0.65 for the existing fall risk assessment tool. The calibration curves for the model displayed more reliable results than those for the fall risk assessment tools alone. In addition, nursing intervention data showed potential contributions to reducing the variance in the fall rate as did the risk factors of individual patients.

CONCLUSIONS

A risk prediction model that considers longitudinal EMR data including nursing interventions can improve the ability to identify individual patients likely to fall.
The Association Between the Use of Antenatal Care Smartphone Apps in Pregnant Women and Antenatal Depression: Cross-Sectional Study (Preprint)
Authors: Mo Yushi , Gong Wenjie , Wang Joyce , Sheng Xiaoqi , Xu Dong R
Published: July 2018

BACKGROUND

Antenatal care smartphone apps are increasingly used by pregnant women, but studies on their use and impact are scarce.

OBJECTIVE

This study investigates the use of antenatal care apps in pregnant women and explores the association between the use of these apps and antenatal depression.

METHODS

This study used a convenient sample of pregnant women recruited from Hunan Provincial Maternal and Child Health Hospital in November 2015. The participants were surveyed for their demographic characteristics, use of antenatal care apps, and antenatal depression. Factors that influenced antenatal pregnancy were analyzed using logistic regression.

RESULTS

Of the 1304 pregnant women, 71.31% (930/1304) used antenatal care apps. Higher usage of apps was associated with urban residency, nonmigrant status, first pregnancy, planned pregnancy, having no previous children, and opportunity to communicate with peer pregnant women. The cutoff score of the Edinburgh Postnatal Depression Scale was 10, and 46.11% (601/1304) of the pregnant women had depression. Logistic regression showed that depression was associated with the availability of disease-screening functions in the apps (odds ratio (OR) 1.78, 95% CI 1.03-3.06) and spending 30 minutes or more using the app (OR 2.05, 95% CI 1.19-3.52). Using apps with social media features was a protective factor for antenatal depression (OR 0.33, 95% CI 0.12-0.89).

CONCLUSIONS

The prevalence of the use of prenatal care apps in pregnant women is high. The functions and time spent on these apps are associated with the incidence of antenatal depression.
Chemistry education student response toward general biology course: A descriptive study
Authors: Marneli Diyyan , Husni Lailatul
Published: July 2018

Chemistry and biology are interrelated branches of science, but students majoring in Chemistry Education are often considered as less ability to understand several biological concepts. The aim of this study was to obtain the information about the response of Chemistry Education students on General Biology course. The research was a descriptive study conducted in August to December 2017 in which the subjects were twenty-four first-semester students of Chemistry Education who take General Biology course at Faculty of Tarbiyah and Teaching Sciences, State Islamic Institute Batusangkar, West Sumatera. The instrument used was the questionnaire of student responses on General Biology course. The analysis used was descriptive statistical analysis by using percentage.  The best response of students on General Biology course is on assessment transparency aspect, while the lowest response is on lecture attractiveness aspect. The conclusion, the response of Chemistry Education student who has taken General Biology course in State Islamic Institute Batusangkar on the criteria good. Although from Chemistry Education Program, most students give positive responses to General Biology course. Information obtained from this study can be used as a basis for improving the quality of General Biology course, especially in Chemistry Education Program.
Research methods and data analysis techniques in education articles published by Indonesian biology educational journals
Authors: Fauzi Ahmad , Pradipta Ika Wahyu
Published: July 2018

The essential of studies which focus on research methods in biology educational field is providing recommendations for the next researchers the proper methods they need to use. Unfortunately, this kind of research is still hard to find in Indonesia. The aim of this study was to access the diversity of research approaches, designs, variables, data collection and analysis techniques, as well as research subjects in the articles published in Indonesian biology educational journals throughout 2017. Content analysis was used as the research design in this study in which as many as 122 articles were analyzed. The results revealed that the most type, design, variable, data collection and analysis techniques, as well as the subject which frequently used were R&D, Quasi-experimental, media/learning sources, questionnaire, frequency and percentage, and senior high school respectively. There were variety of approaches, designs, data collection and analysis techniques, as considerable as research subjects which have been used in educational research. Moreover, there also findings that some several studies with the same research design applied different data collection and data analysis techniques. Thus, it is suggested to the next researchers to choose the most proper methods in conducting their researches.
Estadificación del cáncer colorrectal mediante resonancia magnética
Authors: Jaramillo Felipe Aluja , Upegui Jiménez Daniel
Published: July 2018

El cáncer colorrectal es la cuarta causa de muerte a nivel mundial y la quinta causa de muerte por cáncer en Colombia. La resonancia magnética es la modalidad ideal para la valoración del cáncer colorrectal, ya que permite la estadificación mediante la determinación de la invasión más allá de la muscular propia, la extensión hacia órganos adyacentes, la identificación de pacientes candidatos a quimioterapia o radioterapia prequirúrgica y la planeación del procedimiento quirúrgico. El punto clave se basa en la diferenciación entre los estadios T2 y T3 mediante el uso de secuencias con información T2 de alta resolución. Además de esto, permite la valoración del tamaño y la morfología de los ganglios linfáticos, y aumenta considerablemente la especificidad para la detección de compromiso ganglionar. La resonancia magnética es una técnica con una alta especificidad y una alta reproducibilidad.
Tumor del estroma gastrointestinal (TEGI): terapia adyuvante ¿Cuánto tiempo?
Authors: Oliveros Wilches Ricardo , Bonilla Castañeda Ana , Facundo Navia Helena , Sánchez Pedraza Ricardo
Published: July 2018

La cirugía es el tratamiento establecido para pacientes con tumor del estroma gastrointestinal (TEGI) primario completamente resecable. Luego de la cirugía, se pueden presentar recurrencias hasta en 50% de los casos en los 2 primeros años, especialmente en pacientes con alto riesgo. Esto justifica la terapia adyuvante con imatinib (IMB). Debido a la evidencia clínica, se sabe que 3 años de tratamiento es el tiempo establecido para pacientes con alto riesgo de recurrencia; sin embargo, también se conoce por los mismos estudios clínicos, que las recurrencias comienzan a detectarse de nuevo 6 a 9 meses después de suspender el medicamento. Se presentaron 3 pacientes llevados a cirugía con resección completa de la lesión, quienes recibieron imatinib por 3 años. Meses después de suspender el medicamento, presentaron recurrencia, lo que obligó nuevamente su administración. La duración óptima del tratamiento adyuvante con IMB no está establecida, y no es claro si el IMB realmente cura la enfermedad. Por este motivo, se plantea la necesidad de revisar por cuánto tiempo se debe administrar la terapia adyuvante con IMB y el efecto que el IMB realmente tiene sobre la enfermedad. En conclusión, por la evidencia actual se sabe que la recomendación es de 3 años de tratamiento con IMB como terapia adyuvante, pero con base en la experiencia diaria y con las recomenda- ciones de expertos, existen pacientes que probablemente necesiten continuar con imatinib por mucho más tiempo mientras se informan los resultados de los estudios clínicos de 5 años de tratamiento con IMB.
Falla hepática aguda sobre crónica
Authors: Pérez Guerra Verónica , Ramírez Cardona Laura , Yepes Grajales Oscar , Vélez Rivera Juan David , Marín Zuluaga Juan Ignacio
Published: July 2018

La falla hepática aguda sobre crónica (ACLF, del inglés Acuteon Chronic Liver Failure) comprende el deterioro agudo de la función hepática en un paciente que tiene de base una enfermedad hepática crónica de novo o conocida y desencadenada por diferentes factores precipitantes que pueden ser hepáticos o extrahepáticos. Dentro de las manifestaciones clínicas se encuentran: disfunción renal, encefalopatía hepática y falla orgá- nica multisistémica, que de no ser tratadas oportunamente se traducen en mal pronóstico. Se han utilizado varias puntuaciones para valorar la función hepática y el pronóstico de los pacientes. A pesar de que la falla orgánica multisistémica es una contraindicación para el trasplante hepático, este sigue siendo la mejor opción de tratamiento para estos pacientes.
Considering Tyler’s Curriculum Model in Health and Physical Education
Authors: Cruickshank Vaughan
Published: July 2018

Tyler’s objectives curriculum model has been a strong influence in the field of curriculum development since its publication in 1949. The influence of this model remains strong despite its age, demonstrating the importance of the questions Tyler based his model around. This discussion paper examines Tyler’s (1949) objectives curriculum model; particularly its advantages and disadvantages and its current relevance. This analysis will occur with the context of health and physical education subject area.
International Mindedness and Intercultural Competence: Perceptions of Pakistani Higher Education Faculty
Authors: Habib Zehra
Published: July 2018

This qualitative study endeavored to examine higher education faculty members’ understanding of international mindedness and intercultural competence and sought their views on professional development programs competency in evolving an internationally minded stance. The focus of this study was on international mindedness because in the current era of globalization, it has become imperative to inculcate world mindedness in students and to prepare them for global citizenship. Data were collected through in-depth individual interviews held with eight faculty members teaching at two higher education institutions in Karachi, Pakistan. Dominant findings demonstrated that most participants had limited insight regarding the concepts and that these were applied minimally in their current teaching practices. Although, lauding an international minded approach, most participants considered understanding of local cultures more relevant before moving on to international visions. Participating faculty also reflected that there was lack of professional development and that for understanding local and international dynamics, specialized education programs were an important factor. The study concluded with implications for professional growth platforms to foster global mindedness in educators in order for them to promote international mindedness in students.

 
Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets
Authors: Veluthakal Rajakrishnan , Chepurny Oleg G. , Leech Colin A. , Schwede Frank , Holz George G. , Thurmond Debbie C.
Published: July 2018

Glucose metabolism stimulates cell division control protein 42 homolog (Cdc42)-p21-activated kinase (Pak1) activity and initiates filamentous actin (F-actin) cytoskeleton remodeling in pancreatic β-cells so that cytoplasmic secretory granules can translocate to the plasma membrane where insulin exocytosis occurs. Since glucose metabolism also generates cAMP in β-cells, the cross talk of cAMP signaling with Cdc42-Pak1 activation might be of fundamental importance to glucose-stimulated insulin secretion (GSIS). Previously, the type-2 isoform of cAMP-regulated guanine nucleotide exchange factor 2 (Epac2) was established to mediate a potentiation of GSIS by cAMP-elevating agents. Here we report that nondiabetic human islets and INS-1 832/13 β-cells treated with the selective Epac activator 8-pCPT-2′-O-Me-cAMP-AM exhibited Cdc42-Pak1 activation at 1 mmol/L glucose and that the magnitude of this effect was equivalent to that which was measured during stimulation with 20 mmol/L glucose in the absence of 8-pCPT-2′-O-Me-cAMP-AM. Conversely, the cAMP antagonist Rp-8-Br-cAMPS-pAB prevented glucose-stimulated Cdc42-Pak1 activation, thereby blocking GSIS while also increasing cellular F-actin content. Although islets from donors with type 2 diabetes had profound defects in glucose-stimulated Cdc42-Pak1 activation and insulin secretion, these defects were rescued by the Epac activator so that GSIS was restored. Collectively, these findings indicate an unexpected role for cAMP as a permissive or direct metabolic coupling factor in support of GSIS that is Epac2 and Cdc42-Pak1 regulated.
Significance of early diagnosis and early intervention in early childhood hearing loss
Authors: Şahlı Ayşe Sanem
Published: July 2018

Hearing loss is an important problem interfering with the propagation of acoustic signal starting from the external ear to the primary auditory center of the brain. The congenital hearing loss is an important and common disorder that can lead to many consecutive negative conditions when it is not diagnosed and treated within the first few months of life. Early Hearing Diagnosis and Intervention programs becoming more increasingly popular in recent years aim to avoid the negative effects of hearing loss. The main goal of these programs is to maximize the linguistic proficiency and literacy development of children with hearing loss. Children who are not given the appropriate opportunities for learning language fall behind their peers with normal hearing in communication, reading, cognitive and socio-emotional development. Delays occurring in these fields manifest as a lower educational status and vocational employment problem in adulthood. Therefore, diagnosing and treating hearing loss as early as possible is extremely important.
The pillars of the polish economy’s internationally competitive position in the post-accession period
Authors: Molendowski Edward
Published: July 2018

The article presents the results of an analysis which attempts to identify the most important factors determining changes in the Polish economy’s internationally competitive position compared to the other new member states of the European Union (EU-10) in the years 2004-2017. The hypothesis that, among the EU-10 states, Poland belongs to those where varied effects of membership have clearly occurred has been put forward. This has greatly influenced the formation of the internationally competitive position of the economy.  In the research, analysis of the secondary data concerning the pillars of the economy’s competitiveness specified in the Global Competitiveness Report has been applied. This has been compiled by the World Economic Forum. The article ends with a summary of the most important conclusions drawn from the presented analysis.
THE LIVED BODY AS PRE-REFLECTIVE CONSCIOUSNESS: MERLEAU-PONTY ON THE COGITO
Authors: DE SOUSA Luís Aguiar
Published: July 2018

In this paper, I sketch out Merleau-Ponty’s theory of subjectivity as it is presented in the Phenomenology of Perception. I will start by showing that Merleau-Ponty’s theory presupposes Sartre’s notion of consciousness as anonymous and pre-reflective. Merleau-Ponty takes up these features and embeds them in the lived body. The result is Merleau-Ponty’s notion of the tacit cogito as pre-reflective subjectivity, always presupposed in our everyday embodied engagement with the world and in every explicit reflexive grasp of ourselves as such. Further, I show that the outcome of reflection, the spoken cogito, presupposes linguistic ability and thus the expressive power of the body. In the end I argue that, contrary to Sartre, who viewed pre-reflective consciousness as a nothing, for Merleau-Ponty the lived body or tacit cogito is always something in and of the world.
PHENOMENOLOGY AND IMAGINATION IN HEIDEGGER’S INTERPRETATION OF KANT
Authors: LENGYEL Zsuzsanna Mariann
Published: July 2018

The purpose of our contribution in this paper is to provide an overview of development of Heidegger’s account of imagination with a special focus to the affinity between phenomenology and psychology. (I.) Firstly, we reconstruct how – by his reading Husserl and Aristotle – the early Heidegger got to know the function of imagination as it can open the realm of the things themselves. (II.) Secondly, we investigate that in his Kant-book, Heidegger gave up his plan to further think the viewpoints envisioned by Husserl and the Neo-Kantians, and he entirely transformed his previous concept of imagination by the chapter on Schematism. Ourcore thesis is that Heidegger’s account of imagination is concerned with the emergence of schemes of our thinking, that is to say, Heidegger went beyond the psychological Kant-interpretation, and at the same time he turned to discover the field of phenomenological unconscious.
Contribuciones a la flora vascular de la provincia de Málaga (Andalucía, España)
Authors: Casimiro-Soriguer Solanas Federico , Cabezudo Artero Baltasar
Published: July 2018

Contribuciones a la flora vascular de la provincia de Málaga (Andalucía, España)
CYCLONES OVER THE PACIFIC OCEAN AND FAR-EASTERN SEAS IN COLD AND WARM SEASONS AND THEIR INFLUENCE ON WIND AND THERMAL REGIME IN THE LAST TWO DECADE PERIOD
Authors: Glebova S. Yu.
Published: July 2018

Cyclonic activity in the Asia-Pacific region is largely determined by state of the seasonal centers of atmosphere action. In turn, cyclones themselves influence on conditions in certain «key» areas. Recently the Aleutian Low activity declines in fall-winter and this center is shifted westward, but activity of the Hawaiian High increases in warm season. As the result, heightened air pressure prevails over the Ocean (positive anomalies of the sea level pressure) and lowered pressure (negative anomalies) — over the Far Eastern Seas. In this anomalous situation, the number of cyclones over the Ocean has increased but they become weaker that causes SST increasing in the North Pacific both in winter and summer. Over the Bering Sea, the cyclones become weaker, as well, but this regime causes the ice cover increasing, so SST decreasing in spring. On the contrary, over the Okhotsk Sea and Kuril Islands area, the number of cyclones has decreased gradually but they become stronger in both seasons that causes the ice cover reducing and spring SST rising. In the Japan Sea, cyclonic activity has intensified, too, but this tendency causes cooling in winter and warming in summer.
SEASONAL CHANGES OF VERTICAL PROFILES OF CHLOROPHYLL A IN THE AMUR BAY (JAPAN SEA)
Authors: Zharova A. D. , Zuenko Yu. I.
Published: July 2018

Seasonal changes of chlorophyll a profiles are traced over the Amur Bay (Peter the Great Bay, Japan Sea) in May-October, 2017 by means of oceanographic sonde-profiler equipped with fluorometer. Two principally different types of the vertical profiles are revealed, which were formed by different mechanisms of productivity: i) Chl a concentration had the maximum at the sea surface and decreased with the depth in the internal part of the bay occupied by the estuarine waters, and ii) Chl a concentration had the maximum below the seasonal pycnocline in the external part of the bay connected with the open sea. The highest Chl a concentration was observed in July-August for the estuarine type because of summer monsoon flood on the rivers, but in September for the marine type because of the coastal upwelling induced by monsoon winds change. Comparing these results with estimations of Chl a concentration made with the satellite data, insufficient correspondence is concluded for the external part of the bay, outside the estuarine zone, because the satellite data don’t reflect well the chlorophyll a in the subsurface layer and its seasonal variations. Thus, underestimation of real productivity and feeding ability of marine areas is available with the satellite data on chlorophyll a.