bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated Double-Sided Random Microlens Array Used for Laser Beam Homogenization
Authors: Yuan Wei , Xu Cheng , Xue Li , Pang Hui , Cao Axiu , Fu Yongqi , Deng Qiling
Published: June 2021

Double microlens arrays (MLAs) in series can be used to divide and superpose laser beam so as to achieve a homogenized spot. However, for laser beam homogenization with high coherence, the periodic lattice distribution in the homogenized spot will be generated due to the periodicity of the traditional MLA, which greatly reduces the uniformity of the homogenized spot. To solve this problem, a monolithic and highly integrated double-sided random microlens array (D-rMLA) is proposed for the purpose of achieving laser beam homogenization. The periodicity of the MLA is disturbed by the closely arranged microlens structures with random apertures. And the random speckle field is achieved to improve the uniformity of the homogenized spot by the superposition of the divided sub-beams. In addition, the double-sided exposure technique is proposed to prepare the rMLA on both sides of the same substrate with high precision alignment to form an integrated D-rMLA structure, which avoids the strict alignment problem in the installation process of traditional discrete MLAs. Then the laser beam homogenization experiments have been carried out by using the prepared D-rMLA structure. The laser beam homogenized spots of different wavelengths have been tested, including the wavelengths of 650 nm (R), 532 nm (G), and 405 nm (B). The experimental results show that the uniformity of the RGB homogenized spots is about 91%, 89%, and 90%. And the energy utilization rate is about 89%, 87%, 86%, respectively. Hence, the prepared structure has high laser beam homogenization ability and energy utilization rate, which is suitable for wide wavelength regime.
On the History, Presence, and Future of Optics Manufacturing
Authors: Gerhard Christoph
Published: June 2021

In 1850, Austen Henry Layard discovered an approximately 3000-year-old, simple optical lens in Nimrud, Northern Iraq—the Nimrud lens, aka the Layard lens [...]
Transport of Aerosols in Underground Mine Workings in Terms of SARS-CoV-2 Virus Threat
Authors: Skubacz Krystian , Hildebrandt Robert , Zgórska Aleksandra , Dyduch Zdzisław , Samolej Krzysztof , Smolinski Adam
Published: June 2021

This paper presents a method of implementation and the results of aerosol dispersion tests in underground mine workings. Numerous tests were carried out to determine the potential risk of SARS-CoV-2 coronavirus infection in the underground environment of the mines. The influence of selected parameters of mine air on the possibility and method of aerosol transmission through ventilation routes was experimentally determined in real conditions. The concentration of additional aerosols in the class of ultrafine and fine aerosols increased with the distance from the generator, while the concentration of coarse particles decreased. Assuming the consumption of the solution with which aerosols were generated, even at a small level of 1 cm3/min., the number of additional aerosols was several hundred particles in one cubic centimeter of air at a distance of 50–70 m from the generator. The concentration of ultrafine particles in the range of 40–20,000 nm increased from 122 particles/cm3 to 209 particles/cm3 at air temperature of 12 °C and relative humidity of 95–96%, and from 90 particles/cm3 to 243 particles/cm3 at air temperature of 17 °C and relative humidity of 76–82%, with the increasing distance from the generator (10 m to 50 m).
Detection of Frozen–Thawed Duck Fatty Liver by MALDI-TOF Mass Spectrometry: A Chemometrics Study
Authors: Aubry Laurent , Sayd Thierry , Ferreira Claude , Chambon Christophe , Vénien Annie , Blinet Sylvie , Bourin Marie , Travel Angélique , Halgrain Maeva , Santé-Lhoutellier Véronique , Théron Laetitia
Published: June 2021

The marketing of poultry livers is only authorized as fresh, frozen, or deep-frozen. The higher consumer demand for these products for a short period of time may lead to the marketing of frozen–thawed poultry livers: this constitutes fraud. The aim of this study was to design a method for distinguishing frozen–thawed livers from fresh livers. For this, the spectral fingerprint of liver proteins was acquired using Matrix-Assisted Laser Dissociation Ionization-Time-Of-Flight mass spectrometry. The spectra were analyzed using the chemometrics approach. First, principal component analysis studied the expected variability of commercial conditions before and after freezing–thawing. Then, the discriminant power of spectral fingerprint of liver proteins was assessed using supervised model generation. The combined approach of mass spectrometry and chemometrics successfully described the evolution of protein profile during storage time, before and after freezing-thawing, and successfully discriminated the fresh and frozen–thawed livers. These results are promising in terms of fraud detection, providing an opportunity for implementation of a reference method for agencies to fight fraud.
The Two Faces of the Guanyl Radical: Molecular Context and Behavior
Authors: Chatgilialoglu Chryssostomos
Published: June 2021

The guanyl radical or neutral guanine radical G(-H)• results from the loss of a hydrogen atom (H•) or an electron/proton (e–/H+) couple from the guanine structures (G). The guanyl radical exists in two tautomeric forms. As the modes of formation of the two tautomers, their relationship and reactivity at the nucleoside level are subjects of intense research and are discussed in a holistic manner, including time-resolved spectroscopies, product studies, and relevant theoretical calculations. Particular attention is given to the one-electron oxidation of the GC pair and the complex mechanism of the deprotonation vs. hydration step of GC•+ pair. The role of the two G(-H)• tautomers in single- and double-stranded oligonucleotides and the G-quadruplex, the supramolecular arrangement that attracts interest for its biological consequences, are considered. The importance of biomarkers of guanine DNA damage is also addressed.
Moringa oleifera Lam. in Diabetes Mellitus: A Systematic Review and Meta-Analysis
Authors: Watanabe Shihori , Okoshi Hiyori , Yamabe Shizuko , Shimada Masako
Published: June 2021

Plant-derived phytochemicals have been interested in as nutraceuticals for preventing the onset and progress of diabetes mellitus and its serious complications in recent years. Moringa oleifera Lam. is used in vegetables and in herbal medicine for its health-promoting properties against various diseases including diabetes mellitus. This study aimed to examine an effect of Moringa oleifera on diabetic hyperglycemia and dyslipidemia by meta-analyzing the current evidence of diabetic rodent models. Peer-reviewed studies written in English from two databases, PubMed and Embase, were searched to 30 April 2021. Studies reporting blood glucose or lipid levels in diabetic rodents with and without receiving extracts of Moringa oleifera were included. Forty-four studies enrolling 349 diabetic rodents treated with extracts of Moringa oleifera and 350 diabetic controls reported blood glucose levels. The pooled effect size was −3.92 (95% CI: −4.65 to −3.19) with a substantial heterogeneity. This effect was likely to be, at least in part, modified by the type of diabetic models. Moreover, diabetic hypertriglyceridemia and hypercholesterolemia were also significantly improved in diabetic rodent models treated with Moringa oleifera.
Recyclable Catalysts for Alkyne Functionalization
Authors: Trigoura Leslie , Xing Yalan , Chauhan Bhanu P. S.
Published: June 2021

In this review, we present an assessment of recent advances in alkyne functionalization reactions, classified according to different classes of recyclable catalysts. In this work, we have incorporated and reviewed the activity and selectivity of recyclable catalytic systems such as polysiloxane-encapsulated novel metal nanoparticle-based catalysts, silica–copper-supported nanocatalysts, graphitic carbon-supported nanocatalysts, metal organic framework (MOF) catalysts, porous organic framework (POP) catalysts, bio-material-supported catalysts, and metal/solvent free recyclable catalysts. In addition, several alkyne functionalization reactions have been elucidated to demonstrate the success and efficiency of recyclable catalysts. In addition, this review also provides the fundamental knowledge required for utilization of green catalysts, which can combine the advantageous features of both homogeneous (catalyst modulation) and heterogeneous (catalyst recycling) catalysis.
A Multidisciplinary Approach to Coronavirus Disease (COVID-19)
Authors: Gediz Erturk Aliye , Sahin Arzu , Bati Ay Ebru , Pelit Emel , Bagdatli Emine , Kulu Irem , Gul Melek , Mesci Seda , Eryilmaz Serpil , Oba Ilter Sirin , Yildirim Tuba
Published: June 2021

Since December 2019, humanity has faced an important global threat. Many studies have been published on the origin, structure, and mechanism of action of the SARS-CoV-2 virus and the treatment of its disease. The priority of scientists all over the world has been to direct their time to research this subject. In this review, we highlight chemical studies and therapeutic approaches to overcome COVID-19 with seven different sections. These sections are the structure and mechanism of action of SARS-CoV-2, immunotherapy and vaccine, computer-aided drug design, repurposing therapeutics for COVID-19, synthesis of new molecular structures against COVID-19, food safety/security and functional food components, and potential natural products against COVID-19. In this work, we aimed to screen all the newly synthesized compounds, repurposing chemicals covering antiviral, anti-inflammatory, antibacterial, antiparasitic, anticancer, antipsychotic, and antihistamine compounds against COVID-19. We also highlight computer-aided approaches to develop an anti-COVID-19 molecule. We explain that some phytochemicals and dietary supplements have been identified as antiviral bioproducts, which have almost been successfully tested against COVID-19. In addition, we present immunotherapy types, targets, immunotherapy and inflammation/mutations of the virus, immune response, and vaccine issues.
Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals
Authors: Fouad Ali , Marzouk Adel A. , Shaykoon Montaser Sh. A. , Ibrahim Samy M. , El-Adl Sobhy M. , Ghanem Ashraf
Published: June 2021

Daptomycin, a macrocyclic antibiotic, is here used as a new chiral selector in preparation of chiral stationary phase (CSP) in a recently prepared polymer monolithic capillary. The latter is prepared using the copolymerization of the monomers glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in the presence of daptomycin in water. Under reversed phase conditions (RP), the prepared capillaries were tested for the enantioselective nanoliquid chromatographic separation of fifty of the racemic drugs of different pharmacological groups, such as adrenergic blockers, H1-blockers, NSAIDs, antifungal drugs, and others. Baseline separation was attained for many drugs under RP-HPLC. Daptomycin expands the horizon of chiral selectors in HPLC.
Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins
Authors: Rimpelová Silvie , Kolář Michal , Strnad Hynek , Ruml Tomáš , Vítek Libor , Gbelcová Helena
Published: June 2021

Statins have been widely used for the treatment of hypercholesterolemia due to their ability to inhibit HMG-CoA reductase, the rate-limiting enzyme of de novo cholesterol synthesis, via the so-called mevalonate pathway. However, their inhibitory action also causes depletion of downstream intermediates of the pathway, resulting in the pleiotropic effects of statins, including the beneficial impact in the treatment of cancer. In our study, we compared the effect of all eight existing statins on the expression of genes, the products of which are implicated in cancer inhibition and suggested the molecular mechanisms of their action in epigenetic and posttranslational regulation, and in cell-cycle arrest, death, migration, or invasion of the cancer cells.
Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177® (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction
Authors: Aliaga Joseph , Bonaventura Aldo , Mezzaroma Eleonora , Dhakal Yogesh , Mauro Adolfo Gabriele , Abbate Antonio , Toldo Stefano
Published: June 2021

Interleukin-1β (IL-1β), a product of the NLRP3 inflammasome, modulates cardiac contractility and diastolic function. We proposed that OLT1177® (dapansutrile), a novel NLRP3 inhibitor, could preserve contractile reserve and diastolic function after myocardial infarction (MI). We used an experimental murine model of severe ischemic cardiomyopathy through the ligation of the left coronary artery without reperfusion, and after 7 days randomly assigned mice showing large anterior MI (>4 akinetic segments), increased left ventricular (LV) dimensions ([LVEDD] > 4.4 mm), and reduced function (LV ejection fraction < 40%) to a diet that was enriched with OLT1177® admixed with the chow in the diet at 3.75 g/kg (Group 1 [n = 10]) or 7.5 g/kg (Group 2 [n = 9]), or a standard diet as the no-treatment control group (Group 3 [n = 10]) for 9 weeks. We measured the cardiac function and contractile reserve with an isoproterenol challenge, and the diastolic function with cardiac catheterization at 10 weeks following the MI surgery. When compared with the control (Group 3), the mice treated with OLT1177 (Group 1 and 2) showed significantly greater preservation of their contractile reserve (the percent increase in the left ventricular ejection fraction [LVEF] after the isoproterenol challenge was +33 ± 11% and +40 ± 6% vs. +9 ± 7% in the standard diet; p < 0.05 and p < 0.005 for Group 1 and 2, respectively) and of diastolic function measured as the lower left ventricular end-diastolic pressure (3.2 ± 0.5 mmHg or 4.5 ± 0.5 mmHg vs. 10.0 ± 1.6 mmHg; p < 0.005 and p < 0.009 respectively). No differences were noted between the resting LVEF of the MI groups. These effects were independent of the effects on the ventricular remodeling after MI. NLRP3 inflammasome inhibition with OLT1177® can preserve β-adrenergic responsiveness and prevent left ventricular diastolic dysfunction in a large non-reperfused anterior MI mouse model. OLT1177® could therefore be used to prevent the development of heart failure in patients with ischemic cardiomyopathy.
Comparison of Nitrogen Treatment by Four Onsite Wastewater Systems in Nutrient-Sensitive Watersheds of the North Carolina Coastal Plain
Authors: Humphrey Charles P. , O’Driscoll Michael , Iverson Guy
Published: June 2021

Wastewater may be a source of nitrogen (N) to groundwater and surface waters if not effectively treated. In North Carolina, onsite wastewater systems (OWSs) are used by 50% of the population for wastewater treatment, but most OWSs are not routinely monitored. There is a lack of information regarding the N contributions from OWSs to water resources. Four sites with OWSs were instrumented with groundwater wells near their drainfield trenches to compare N concentrations in groundwater to concentrations in wastewater and to determine the N treatment efficiency of the systems. Two OWSs (Site 200 and 300) were less than 1 year old, and two (Site 100 and 400) were more than 10 years old at the start of the study. Two OWSs (Site 100 and 200) used pressure dosing, while two OWSs (Site 300 and 400) used gravity distribution. The mean N treatment efficiency of the four OWSs was 77%. The new OWSs were more efficient (92%) relative to the older OWSs (62%) at reducing N concentrations. Similar N treatment efficiencies were observed when pooling data for the pressure dosed (77%) and gravity (79%) OWSs. Each OWS influenced groundwater by causing increases in N concentrations. It is important that new OWSs are installed at a shallow depth and with sufficient separation to groundwater to promote the aerobic treatment of wastewater. Remediation strategies including the installation of permeable reactive barriers or the use of media filters may be needed in some areas to reduce N transport from existing OWS.
Oxygen: A New Open Access Journal Focused on the Biology and Chemistry of This Essential Molecule
Authors: Hancock John T.
Published: June 2021

Oxygen (ISSN 2673-9801) is a new and exciting open access journal which will embrace research based on this essential molecule [...]
Feasibility Analysis of Bolted Joints with Composite Fibre-Reinforced Thermoplastics
Authors: Tobalina-Baldeon Daniel , Sanz-Adán Felix , Martinez-Calvo Marian , Gómez Carmelo , Sanz-Pena Inigo , Cavas Francisco
Published: June 2021

The use of composite materials has shown steady growth in recent years due to their excellent specific mechanical properties and the possibility to reduce the weight of vehicles without impairing their safety and comfort. Continuous fibre-reinforced thermoplastic composites (CFRTP) show dynamic, acoustic, and damping properties far superior to steel and can be recycled and repaired. Their excellent properties make CFRTP good candidates for anti-vibration and shock absorbing components, however, out-of-plane mechanical properties hinder the anchoring to the vehicle’s body by means of bolted connections. The results obtained in this study show how the maximum torque that can be applied without cracks or breakage phenomena is lower than in standard steel joints. Although the preload’s value is admissible, this one is reduced over time due to relaxation phenomena associated with the viscoelastic behaviour of thermoplastic matrix. The results obtained can be improved with the integration of metal inserts in connections’ areas. In this study, a case study of a gear mount replacing the steel core with CFRTP reinforced with inserts is carried out. The results show a reduction above 50% in weight, opening the possibility of lighter structures in the automotive sector.
Gum Rosin as a Size Control Agent of Poly(Butylene Adipate-Co-Terephthalate) (PBAT) Domains to Increase the Toughness of Packaging Formulations Based on Polylactic Acid (PLA)
Authors: Aldas Miguel , Ferri José Miguel , Motoc Dana Luca , Peponi Laura , Arrieta Marina Patricia , López-Martínez Juan
Published: June 2021

Gum rosin (GR) was used as a natural additive to improve the compatibility between polylactic acid, PLA, and poly(butylene adipate-co-terephthalate, PBAT, blended with 20 wt.% of PBAT (PLA/PBAT). The PBAT was used as a soft component to increase the ductility of PLA and its fracture toughness. The coalescence of the PBAT domains was possible due to the plasticization effect of the GR component. These domains contributed to increasing the toughness of the final material due to the variation and control of the PBAT domains’ size and consequently, reducing the stress concentration points. The GR was used in contents of 5, 10, 15, and 20 phr. Consequently, the flexural properties were improved and the impact resistance increased up to 80% in PLA/PBAT_15GR with respect to the PLA/PBAT formulation. Field emission scanning electron microscope (FESEM) images allowed observing that the size of PBAT domains of 2–3 µm was optimal to reduce the impact stress. Differential scanning calorimetry (DSC) analysis showed a reduction of up to 8 °C on the PLA melting temperature and up to 5.3 °C of the PLA glass transition temperature in the PLA/PBAT_20GR formulation, which indicates an improvement in the processability of PLA. Finally, transparent films with improved oxygen barrier performance and increased hydrophobicity were obtained suggesting the potential interest of these blends for the food packaging industry.
Scale-Up of Biosynthesis Process of Bacterial Nanocellulose
Authors: Shavyrkina Nadezhda A. , Budaeva Vera V. , Skiba Ekaterina A. , Mironova Galina F. , Bychin Nikolay V. , Gismatulina Yulia A. , Kashcheyeva Ekaterina I. , Sitnikova Anastasia E. , Shilov Aleksei I. , Kuznetsov Pavel S. , Sakovich Gennady V.
Published: June 2021

Bacterial nanocellulose (BNC) is a unique product of microbiological synthesis, having a lot of applications among which the most important is biomedicine. Objective complexities in scaling up the biosynthesis of BNC are associated with the nature of microbial producers for which BNC is not the target metabolite, therefore biosynthesis lasts long, with the BNC yield being small. Thus, the BNC scale-up problem has not yet been overcome. Here we performed biosynthesis of three scaled sheets of BNC (each having a surface area of 29,400 cm2, a container volume of 441 L, and a nutrient medium volume of 260 L and characterized them. The static biosynthesis of BNC in a semisynthetic nutrient medium was scaled up using the Medusomyces gisevii Sa-12 symbiotic culture. The experiment was run in duplicate. The BNC pellicle was removed once from the nutrient medium in the first experiment and twice in the second experiment, in which case the inoculum and glucose were not additionally added to the medium. The resultant BNC sheets were characterized by scanning electron microscopy, capillary viscosimetry, infrared spectroscopy, thermomechanical and thermogravimetric analyses. When the nutrient medium was scaled up from 0.1 to 260 L, the elastic modulus of BNC samples increased tenfold and the degree of polymerization 2.5-fold. Besides, we demonstrated that scaled BNC sheets could be removed at least twice from one volume of the nutrient medium, with the yield and quality of BNC remaining the same. Consequently, the world’s largest BNC sheets 210 cm long and 140 cm wide, having a surface area of 29,400 cm2 each (weighing 16.24 to 17.04 kg), have been obtained in which an adult with burns or vast wounds can easily be wrapped. The resultant sheets exhibit a typical architecture of cellulosic fibers that form a spatial 3D structure which refers to individual and extremely important characteristics of BNC. Here we thus demonstrated the scale-up of biosynthesis of BNC with improved properties, and this result was achieved by using the symbiotic culture.
Transfer Learning Based Semantic Segmentation for 3D Object Detection from Point Cloud
Authors: Imad Muhammad , Doukhi Oualid , Lee Deok-Jin
Published: June 2021

Three-dimensional object detection utilizing LiDAR point cloud data is an indispensable part of autonomous driving perception systems. Point cloud-based 3D object detection has been a better replacement for higher accuracy than cameras during nighttime. However, most LiDAR-based 3D object methods work in a supervised manner, which means their state-of-the-art performance relies heavily on a large-scale and well-labeled dataset, while these annotated datasets could be expensive to obtain and only accessible in the limited scenario. Transfer learning is a promising approach to reduce the large-scale training datasets requirement, but existing transfer learning object detectors are primarily for 2D object detection rather than 3D. In this work, we utilize the 3D point cloud data more effectively by representing the birds-eye-view (BEV) scene and propose a transfer learning based point cloud semantic segmentation for 3D object detection. The proposed model minimizes the need for large-scale training datasets and consequently reduces the training time. First, a preprocessing stage filters the raw point cloud data to a BEV map within a specific field of view. Second, the transfer learning stage uses knowledge from the previously learned classification task (with more data for training) and generalizes the semantic segmentation-based 2D object detection task. Finally, 2D detection results from the BEV image have been back-projected into 3D in the postprocessing stage. We verify results on two datasets: the KITTI 3D object detection dataset and the Ouster LiDAR-64 dataset, thus demonstrating that the proposed method is highly competitive in terms of mean average precision (mAP up to 70%) while still running at more than 30 frames per second (FPS).
Electrochemical Discrimination of Salbutamol from Its Excipients in VentolinTM at Nanoporous Gold Microdisc Arrays
Authors: Nagle Lorraine C. , Wahl Amelie , Ogourstov Vladimir , Seymour Ian , Barry Fiona , Rohan James F. , Mac Loughlin Ronan
Published: June 2021

The emergence of specific drug–device combination products in the inhalable pharmaceutical industry demands more sophistication of device functionality in the form of an embedded sensing platform to increase patient safety and extend patent coverage. Controlling the nebuliser function at a miniaturised, integrated electrochemical sensing platform with rapid response time and supporting novel algorithms could deliver such a technology offering. Development of a nanoporous gold (NPG) electrochemical sensor capable of creating a unique fingerprint signal generated by inhalable pharmaceuticals provided the impetus for our study of the electrooxidation of salbutamol, which is the active bronchodilatory ingredient in VentolinTM formulations. It was demonstrated that, at NPG-modified microdisc electrode arrays, salbutamol is distinguishable from the chloride excipient present at 0.0154 M using linear sweep voltammetry and can be detected amperometrically. In contrast, bare gold microdisc electrode arrays cannot afford such discrimination, as the potential for salbutamol oxidation and chloride adsorption reactions overlap. The discriminative power of NPG originates from the nanoconfinement effect for chloride in the internal pores of NPG, which selectively enhances the electron transfer kinetics of this more sluggish reaction relative to that of the faster, diffusion-controlled salbutamol oxidation. Sensing was performed at a fully integrated three-electrode cell-on-chip using Pt as a quasi-reference electrode.
Ocean-Bottom Seismographs Based on Broadband MET Sensors: Architecture and Deployment Case Study in the Arctic
Authors: Krylov Artem A. , Egorov Ivan V. , Kovachev Sergey A. , Ilinskiy Dmitry A. , Ganzha Oleg Yu. , Timashkevich Georgy K. , Roginskiy Konstantin A. , Kulikov Mikhail E. , Novikov Mikhail A. , Ivanov Vladimir N. , Radiuk Elena A. , Rukavishnikova Daria D. , Neeshpapa Alexander V. , Velichko Grigory O. , Lobkovsky Leopold I. , Medvedev Igor P. , Semiletov Igor P.
Published: June 2021

The Arctic seas are now of particular interest due to their prospects in terms of hydrocarbon extraction, development of marine transport routes, etc. Thus, various geohazards, including those related to seismicity, require detailed studies, especially by instrumental methods. This paper is devoted to the ocean-bottom seismographs (OBS) based on broadband molecular–electronic transfer (MET) sensors and a deployment case study in the Laptev Sea. The purpose of the study is to introduce the architecture of several modifications of OBS and to demonstrate their applicability in solving different tasks in the framework of seismic hazard assessment for the Arctic seas. To do this, we used the first results of several pilot deployments of the OBS developed by Shirshov Institute of Oceanology of the Russian Academy of Sciences (IO RAS) and IP Ilyinskiy A.D. in the Laptev Sea that took place in 2018–2020. We highlighted various seismological applications of OBS based on broadband MET sensors CME-4311 (60 s) and CME-4111 (120 s), including the analysis of ambient seismic noise, registering the signals of large remote earthquakes and weak local microearthquakes, and the instrumental approach of the site response assessment. The main characteristics of the broadband MET sensors and OBS architectures turned out to be suitable for obtaining high-quality OBS records under the Arctic conditions to solve seismological problems. In addition, the obtained case study results showed the prospects in a broader context, such as the possible influence of the seismotectonic factor on the bottom-up thawing of subsea permafrost and massive methane release, probably from decaying hydrates and deep geological sources. The described OBS will be actively used in further Arctic expeditions.
Embroidered Textile Antennas: Influence of Moisture in Communication and Sensor Applications
Authors: Bonefačić Davor , Bartolić Juraj
Published: June 2021

Moisture causes detuning and increased losses in textile antennas, and it affects resonant and wideband textile antennas differently. In this work, we studied the effect of moisture on a resonant textile planar inverted-F antenna (PIFA) and a wideband textile monopole antenna. Both antennas were manufactured by embroidering conductive yarn in denim textile. The input reflection coefficient, antenna gain, and gain patterns were measured on both antennas for different moisture contents. The results show that wideband antennas are less affected by moisture in comparison with resonant antennas. For communications applications, large moisture content in the textile antenna should be avoided; therefore a flexible, textile-based waterproofing antenna cover was proposed, manufactured, and tested. On the other hand, the effect of antenna detuning by moisture can be used for moisture-sensing application. This concept was demonstrated on the resonant textile PIFA in transmission and reflection setups, showing that the reflection setup gives better results.
Evaluating the Impact of IMU Sensor Location and Walking Task on Accuracy of Gait Event Detection Algorithms
Authors: Niswander Wesley , Kontson Kimberly
Published: June 2021

There are several algorithms that use the 3D acceleration and/or rotational velocity vectors from IMU sensors to identify gait events (i.e., toe-off and heel-strike). However, a clear understanding of how sensor location and the type of walking task effect the accuracy of gait event detection algorithms is lacking. To address this knowledge gap, seven participants were recruited (4M/3F; 26.0 ± 4.0 y/o) to complete a straight walking task and obstacle navigation task while data were collected from IMUs placed on the foot and shin. Five different commonly used algorithms to identify the toe-off and heel-strike gait events were applied to each sensor location on a given participant. Gait metrics were calculated for each sensor/algorithm combination using IMUs and a reference pressure sensing walkway. Results show algorithms using medial-lateral rotational velocity and anterior-posterior acceleration are fairly robust against different sensor locations and walking tasks. Certain algorithms applied to heel and lower lateral shank sensor locations will result in degraded algorithm performance when calculating gait metrics for curved walking compared to straight overground walking. Understanding how certain types of algorithms perform for given sensor locations and tasks can inform robust clinical protocol development using wearable technology to characterize gait in both laboratory and real-world settings.
Intersection Vehicle Turning Control for Fully Autonomous Driving Scenarios
Authors: Ding Zhizhong , Sun Chao , Zhou Momiao , Liu Zhengqiong , Wu Congzhong
Published: June 2021

Currently the research and development of autonomous driving vehicles (ADVs) mainly consider the situation whereby manual driving vehicles and ADVs run simultaneously on lanes. In order to acquire the information of the vehicle itself and the environment necessary for decision-making and controlling, the ADVs that are under development now are normally equipped with a lot of sensing units, for example, high precision global positioning systems, various types of radar, and video processing systems. Obviously, the current advanced driver assistance systems (ADAS) or ADVs still have some problems concerning high reliability of driving safety, as well as the vehicle’s cost and price. It is certain, however, that in the future there will be some roads, areas or cities where all the vehicles are ADVs, i.e., without any human driving vehicles in traffic. For such scenarios, the methods of environment sensing, traffic instruction indicating, and vehicle controlling should be different from that of the situation mentioned above if the reliability of driving safety and the production cost expectation is to be improved significantly. With the anticipation that a more sophisticated vehicle ad hoc network (VANET) should be an essential transportation infrastructure for future ADV scenarios, the problem of vehicle turning control based on vehicle to everything (V2X) communication at road intersections is studied. The turning control at intersections mainly deals with three basic issues, i.e., target lane selection, trajectory planning and calculation, and vehicle controlling and tracking. In this paper, control strategy, model and algorithms are proposed for the three basic problems. A model predictive control (MPC) paradigm is used as the vehicle upper layer controller. Simulation is conducted on the CarSim-Simulink platform with typical intersection scenes.
Transparency Policies in European Public Broadcasters: Sustainability, Digitalisation and Fact-Checking
Authors: Rivera Otero José Manuel , Lagares Díez Nieves , Pereira López María , López-López Paulo Carlos
Published: June 2021

Over the last few years, European public broadcasters have promoted the concept of public service media as one of their main values. To this end, transparency policies have been implemented as a mechanism of corporate projection by strengthening their role as an essential service. The objective of this article is to ascertain the existence of this type of policies among European public broadcasters. To this end, a nominal group was made with 24 experts who were surveyed, thus generating new indicators of transparency and accountability strategies around sustainability and digitalization. The contents of the websites of RTVE (Spain), RTP (Portugal), France TV (France), RAI (Italy), BBC (UK), RTÉ (Ireland), ZDF (Germany), VRT (Belgium), and SVT (Sweden) were also analyzed, paying attention to such indicators and strategies. The main results include the identification of differences on the basis of the ideal models described by Hallin and Mancini; a commitment to credibility (fact-checking) to the detriment of diversity of opinions; and a connection between the political system and the media system, which, preliminarily, determines the level of transparency of these public entities.
Component Modification of Basic Oxygen Furnace Slag with C4AF as Target Mineral and Application
Authors: Zhao Yanrong , Sun Pengliang , Chen Ping , Guan Xiaomin , Wang Yuanhao , Liu Rongjin , Wei Jincan
Published: June 2021

In this paper, a new method of basic oxygen furnace (BOF) slag component modification with a regulator was studied. The main mineral was designed as C4AF, C2S and C3S in modified BOF slag, and the batching method, mineral compositions, hydration rate, activation index and capability of resisting sulfate corrode also were studied. XRD, BEI and EDS were used to characterize the mineral formation, and SEM was used to study the morphology of hydration products. The results show that most inert phase in BOF slag can be converted into active minerals of C4AF and C2S through reasonable batching calculation and the amount of regulating agent. The formation of C4AF and C2S in modified BOF slag is better, and a small amount of MgO is embedded in the white intermediate phase, but C3S is not detected. With the increase in the CaO/SiO2 ratio in raw materials, the CaO/SiO2 ratio of calcium silicate minerals in modified BOF slag increases, the contents of f-CaO are less than 1.0%, and the activity index improves. Compared with the BOF slag, the activity index and exothermic rate of modified BOF slag improved obviously, and the activity index of 90 days is close to 100%. With the increase in modified BOF slag B cement, the flexural strength decrease; however, the capability of resisting sulfate corrode is improved due to the constant formation of a short rod-like shape ettringite in Na2SO4 solution and the improvement of the structure densification of the hydration products.
How Effective Are Existing Phosphorus Management Strategies in Mitigating Surface Water Quality Problems in the U.S.?
Authors: Haque Shama E.
Published: June 2021

Phosphorus is an essential component of modern agriculture. Long-term land application of phosphorous-enriched fertilizers and animal manure leads to phosphorus accumulation in soil that may become susceptible to mobilization via erosion, surface runoff and subsurface leaching. Globally, highly water-soluble phosphorus fertilizers used in agriculture have contributed to eutrophication and hypoxia in surface waters. This paper provides an overview of the literature relevant to the advances in phosphorous management strategies and surface water quality problems in the U.S. Over the past several decades, significant advances have been made to control phosphorus discharge into surface water bodies of the U.S. However, the current use of phosphorus remains inefficient at various stages of its life cycle, and phosphorus continues to remain a widespread problem in many water bodies, including the Gulf of Mexico and Lake Erie. In particular, the Midwestern Corn Belt region of the U.S. is a hotspot of phosphorous fertilization that has resulted in a net positive soil phosphorous balance. The runoff of phosphorous has resulted in dense blooms of toxic, odor-causing phytoplankton that deteriorate water quality. In the past, considerable attention was focused on improving the water quality of freshwater bodies and estuaries by reducing inputs of phosphorus alone. However, new research suggests that strategies controlling the two main nutrients, phosphorus and nitrogen, are more effective in the management of eutrophication. There is no specific solution to solving phosphorus pollution of water resources; however, sustainable management of phosphorus requires an integrated approach combining at least a reduction in consumption levels, source management, more specific regime-based nutrient criteria, routine soil fertility evaluation and recommendations, transport management, as well as the development of extensive phosphorus recovery and recycling programs.
Influence of Experiential Consumption and Social Environment of Local Tourists on the Intention to Revisit Tunisian Guesthouses: Mediating Role of Involvement in the Experience
Authors: Khazami Nesrine , Lakner Zoltan
Published: June 2021

This study aims to examine the relationships between the experiential consumption, the social environment, and intention to revisit. The mediating role of involvement in the experience between experiential consumption and the intention to revisit and between the social environment and the intention to revisit has been expressed and tested. The data for this research was collected from local tourists staying in guesthouses scattered all over Tunisia. The authors applied structural partial least squares equation modeling to analyze 259 questionnaires completed by participants and to test the hypotheses. The authors found a positive and direct effects of the social environment on involvement in the experience while experiential consumption did not. In addition, the results indicated positive and significant indirect effects for the social environment on the intention to revisit through involvement in the experience. The results do not support a mediating role of involvement in experience on the relationship of experiential consumption and intention to revisit. In addition, the results showed a strong and positive effect of involvement in the experience on intention to revisit. This research makes a distinctive theoretical contribution to the literature of perceived experiential value by analyzing the relationships between experiential consumption and the social environment on experience involvement and intention to revisit a guesthouse. In addition, this study explores several practical implications of these results.
The Evolution of Cancer Immunotherapy
Authors: Khan Meshaal , Maker Ajay V. , Jain Shikha
Published: June 2021

Immunotherapy has changed the environment of cancer treatment by providing new and efficacious therapy options for many solid and hematologic malignancies. Although not a new field of oncology, immunotherapy has quickly developed into one of the most flourishing fields in medicine. In this review article, we explore key discoveries which helped to shape our current understanding of the immune system’s role in neoplasms. Many landmark developments include the advancements in checkpoint inhibitors, monoclonal antibodies, CAR-T cells and anti-cancer vaccines. We also explore the drawbacks and efficacy of various categories of immunotherapy. Ongoing investigations within immunotherapy, such as the gut microbiome, combining checkpoint inhibitors and gene sequencing, continue to personalize treatments for cancer patients, providing exciting and endless possibilities for the future.
Type II NKT Cell Agonist, Sulfatide, Is an Effective Adjuvant for Oral Heat-Killed Cholera Vaccines
Authors: Albutti Aqel , Longet Stephanie , McEntee Craig P. , Quinn Shauna , Liddicoat Alex , Rîmniceanu Cristiana , Lycke Nils , Lynch Lydia , Cardell Susanna , Lavelle Ed C.
Published: June 2021

Oral vaccination has the potential to offer a safer and more efficacious approach for protection against enteric pathogens than injection-based approaches, especially in developing countries. One key advantage is the potential to induce intestinal immune responses in addition to systemic immunity. In general, antigen delivery via the oral route triggers weak immune responses or immunological tolerance. The effectiveness of oral vaccination can be improved by co-administering adjuvants. However, a major challenge is the absence of potent and safe oral adjuvants for clinical application. Here, the Type II NKT cell activator sulfatide is shown for the first time to be an effective oral adjuvant for Vibrio cholerae vaccine antigens in a mouse model. Specifically, administration of sulfatide with the oral cholera vaccine Dukoral® resulted in enhancement of intestinal antigen-specific IgA in addition to Th1 and Th17 immune responses. In summary, sulfatide is a promising adjuvant for inclusion in an oral cholera vaccine and our data further support the potential of adjuvants targeting NKT cells in new vaccine strategies.
Investigation of Post Vaccination Reactions of Two Live Attenuated Vaccines against Lumpy Skin Disease of Cattle
Authors: Bamouh Zahra , Hamdi Jihane , Fellahi Siham , Khayi Slimane , Jazouli Mohammed , Tadlaoui Khalid Omari , Fihri Ouafaa Fassi , Tuppurainen Eeva , Elharrak Mehdi
Published: June 2021

Lumpy skin disease virus (LSDV) causes an economically important disease in cattle. The only method for successful control is early diagnosis and efficient vaccination. Adverse effects of vaccination such as local inflammation at the injection site and localized or generalized skin lesions in some vaccinated animals have been reported with live vaccines. The aim of this work was to compare the safety of two lumpy skin disease (LSD) vaccine strains, Kenyan (Kn) Sheep and Goat Pox (KSGP O-240) and LSDV Neethling (Nt) strain, and to determine the etiology of the post-vaccination (pv) reactions observed in cattle. Experimental cattle were vaccinated under controlled conditions with Nt- and KSGP O-240-based vaccines, using two different doses, and animals were observed for 3 months for any adverse reactions. Three out of 45 cattle vaccinated with LSDV Nt strain (6.7%) and three out of 24 cattle vaccinated with Kn strain (12.5%) presented LSD-like skin nodules, providing evidence that the post-vaccination lesions may not be strain-dependent. Lesions appeared 1–3 weeks after vaccination and were localized in the neck or covering the whole body. Animals recovered after 3 weeks. There is a positive correlation between the vaccine dose and the appearance of skin lesions in vaccinated animals; at the 105 dose, 12% of the animals reacted versus 3.7% at the 104 dose. Both strains induced solid immunity when protection was measured by neutralizing antibody seroconversion.
Flavivirus NS1 and Its Potential in Vaccine Development
Authors: Carpio Kassandra L. , Barrett Alan D. T.
Published: June 2021

The Flavivirus genus contains many important human pathogens, including dengue, Japanese encephalitis (JE), tick-borne encephalitis (TBE), West Nile (WN), yellow fever (YF) and Zika (ZIK) viruses. While there are effective vaccines for a few flavivirus diseases (JE, TBE and YF), the majority do not have vaccines, including WN and ZIK. The flavivirus nonstructural 1 (NS1) protein has an unusual structure–function because it is glycosylated and forms different structures to facilitate different roles intracellularly and extracellularly, including roles in the replication complex, assisting in virus assembly, and complement antagonism. It also plays a role in protective immunity through antibody-mediated cellular cytotoxicity, and anti-NS1 antibodies elicit passive protection in animal models against a virus challenge. Historically, NS1 has been used as a diagnostic marker for the flavivirus infection due to its complement fixing properties and specificity. Its role in disease pathogenesis, and the strong humoral immune response resulting from infection, makes NS1 an excellent target for inclusion in candidate flavivirus vaccines.
Considerations for a Respiratory Syncytial Virus Vaccine Targeting an Elderly Population
Authors: Stephens Laura M. , Varga Steven M.
Published: June 2021

Respiratory syncytial virus (RSV) is most commonly associated with acute lower respiratory tract infections in infants and children. However, RSV also causes a high disease burden in the elderly that is often under recognized. Adults >65 years of age account for an estimated 80,000 RSV-associated hospitalizations and 14,000 deaths in the United States annually. RSV infection in aged individuals can result in more severe disease symptoms including pneumonia and bronchiolitis. Given the large disease burden caused by RSV in the aged, this population remains an important target for vaccine development. Aging results in lowered immune responsiveness characterized by impairments in both innate and adaptive immunity. This immune senescence poses a challenge when developing a vaccine targeting elderly individuals. An RSV vaccine tailored towards an elderly population will need to maximize the immune response elicited in order to overcome age-related defects in the immune system. In this article, we review the hurdles that must be overcome to successfully develop an RSV vaccine for use in the elderly, and discuss the vaccine candidates currently being tested in this highly susceptible population.
Knowledge, Vaccination Status, and Reasons for Avoiding Vaccinations against Hepatitis B in Developing Countries: A Systematic Review
Authors: Machmud Putri Bungsu , Glasauer Saskia , Gottschick Cornelia , Mikolajczyk Rafael
Published: June 2021

(1) Background: The coverage of hepatitis B vaccination remains low in developing countries to date. This systematic review thus analyzes the determinants of people’s knowledge and vaccination status as well as the reasons why people in developing countries chose not to receive the hepatitis B vaccination. (2) Methods: We searched four databases to identify all studies from developing countries published within the past 10 years. Both low-risk and high-risk populations aged older than 15 years old were eligible for the study. The quality of studies was assessed by the Newcastle–Ottawa Scale assessment. (3) Results: This study identified 2443 articles, 89 of which were included in the analysis. Monthly income, occupational status, and profession as a health-care worker were the strongest predictive factors for both knowledge of hepatitis B and vaccination status. In addition, strong predictor variables of hepatitis B knowledge were knowing an infected person and level of education, while health insurance, management’s protection at workplace, infection training, and experience of hepatitis B exposure were strong influencing factors for vaccine uptake. (4) Conclusions: Exposure to information, support from institutions, and financial support related to vaccination cost have a positive impact on the knowledge about hepatitis B infection and vaccination coverage.