bluuebunny/crossref_metadata_2025 huggingface dataset:
The use of social media inside and outside the classroom to enhance students’ engagement in EFL contexts
Authors: Wang Hui , Wang Minqi , Li Guang
Published: September 2022

It could be claimed that without any doubt the Internet has revolutionized the educational system to a great extent. Even though some are still interested in traditional ways of teaching and learning and also face-to-face classes, technological advances, in particular, social media have changed the English as a foreign language (EFL) contexts in a way that they will not be compatible with any other methods that have long been utilized before. Despite the fact that some studies have been conducted in different learning contexts, to the researcher’s best knowledge, attention has not been focused on the importance of social media inside and outside the classroom on EFL students’ indulgence. Therefore, the aim of this review is to synthesize the findings of the previous studies to highlight the role of social media in EFL students’ engagement throughout class and outside the class in both face-to-face and online classes. To reach this goal, this review first discusses the impact of social media on engagement, and then engagement and its classifications are dealt with. Next, the relationship between using social media and students’ engagement is discussed. And finally, some implications are proposed.
Spatial cognition and the avian hippocampus: Research in domestic chicks
Authors: Morandi-Raikova Anastasia , Mayer Uwe
Published: September 2022

In this review, we discuss the functional equivalence of the avian and mammalian hippocampus, based mostly on our own research in domestic chicks, which provide an important developmental model (most research on spatial cognition in other birds relies on adult animals). In birds, like in mammals, the hippocampus plays a central role in processing spatial information. However, the structure of this homolog area shows remarkable differences between birds and mammals. To understand the evolutionary origin of the neural mechanisms for spatial navigation, it is important to test how far theories developed for the mammalian hippocampus can also be applied to the avian hippocampal formation. To address this issue, we present a brief overview of studies carried out in domestic chicks, investigating the direct involvement of chicks’ hippocampus homolog in spatial navigation.
Satisfaction with life in workers: A chained mediation model investigating the roles of resilience, career adaptability, self-efficacy, and years of education
Authors: Topino Eleonora , Svicher Andrea , Di Fabio Annamaria , Gori Alessio
Published: September 2022

Satisfaction with life is a core dimension of well-being that can be of great importance in the workplace, in light of the close link between worker health and organizational success highlighted by the perspective of healthy organizations. This study aimed at analyzing the factors associated with satisfaction with life, focusing on the role of resilience, career adaptability, self-efficacy, and years of education. A sample of 315 workers (67% women; Mage = 34.84 years, SD = 12.39) filled out the Satisfaction with Life Scale, General Self-Efficacy Scale, Career Adapt-Abilities Scale, the 10-item Connor-Davidson Resilience Scale, and a demographic questionnaire. Data were analyzed by implementing a chained mediation model. Results showed a significant and positive relationship between resilience and satisfaction with life, partially moderated by the chained effect of career adaptability and self-efficacy, controlling for education. When inserted as a covariate, education showed a significant and negative association with satisfaction with life. Such findings contribute to enriching the field of research on the factors that contribute to the well-being of workers and may have important practical implications for interventions in organizations.
To see or not to see (again): Dealbreakers and dealmakers in relation to social inclusion
Authors: Jonason Peter K. , White Kaitlyn P. , Lowder Abigail H. , Al-Shawaf Laith
Published: September 2022

In this study, we replicated what is known about the relative importance of dealbreakers (i.e., traits avoided) and dealmakers (i.e., traits sought) in romantic and sexual relationships and extended it to an examination of self-reports of mate value, self-esteem, and loneliness. In two experiments (N = 306; N = 304) we manipulated the information people were told about potential partners and asked them about their intentions to have sex again with or go on a second date with opposite sex targets. People were less interested in partners after learning dealbreakers, effects which operated more strongly in the long-term than short-term context, but similarly in men and women. People who reported less self-esteem or more loneliness were more receptive to people with dealbreakers. People who thought they had more mate value, more self-esteem, or less loneliness were more receptive to dealmakers. Results are discussed using sociometer, prospect, and sexual strategies theories.
The relation between rhythm processing and cognitive abilities during child development: The role of prediction
Authors: Frischen Ulrike , Degé Franziska , Schwarzer Gudrun
Published: September 2022

Rhythm and meter are central elements of music. From the very beginning, children are responsive to rhythms and acquire increasingly complex rhythmic skills over the course of development. Previous research has shown that the processing of musical rhythm is not only related to children’s music-specific responses but also to their cognitive abilities outside the domain of music. However, despite a lot of research on that topic, the connections and underlying mechanisms involved in such relation are still unclear in some respects. In this article, we aim at analyzing the relation between rhythmic and cognitive-motor abilities during childhood and at providing a new hypothesis about this relation. We consider whether predictive processing may be involved in the relation between rhythmic and various cognitive abilities and hypothesize that prediction as a cross-domain process is a central mechanism building a bridge between rhythm processing and cognitive-motor abilities. Further empirical studies focusing on rhythm processing and cognitive-motor abilities are needed to precisely investigate the links between rhythmic, predictive, and cognitive processes.
Protocol for randomized control trial of a digital-assisted parenting intervention for promoting Malaysian children’s mental health
Authors: Zulkefly Nor Sheereen , Schaff Anis Raihan Dzeidee , Zaini Nur Arfah , Mukhtar Firdaus , Norowi Noris Mohd , Dahlan Rahima , Said Salmiah Md.
Published: September 2022

Background

Mental illness among Malaysian children is gradually reaching a fundamentally alarming point as it persistently shows increasing trend. The existing literature on the etiologies of children’s mental illness, highlights the most common cause to be ineffective or impaired parenting. Thus, efforts to combat mental illness in children should focus on improving the quality of parenting. Documented interventional studies focusing on this issue, particularly in Malaysia, are scarce and commonly report poor treatment outcomes stemming from inconvenient face-to-face instructions. Consequently, proposing an accessible online and digital-assisted parenting program is expected to reach a larger number of parents, as it can overcome substantial barriers. Hence, this study aims to develop a universal digital-assisted preventive parenting intervention called DaPI, that aims to enhance mental health of children in Malaysia.

Methods

A total of 200 parents of children aged 10–14 years will be recruited and randomized into two groups either intervention or waitlist-control based on a 1:1 ratio for a duration of 8 weeks. Those in the intervention group will receive eight sessions of the DaPI program that focus mainly on parenting and children’s mental health. The primary outcome of this study will essentially focus on the changes in parent-reported parenting behavior and parental self-efficacy. The secondary outcome will be changes in children’s mental health (i.e., behavioral problems and emotional maladjustment). Assessments will be arranged pre- and post-intervention as well as at the 1-month follow-up. Analyses will be conducted using a paired t-test and multivariate analysis of covariance.

Discussion

The expected outcome will be the establishment of DaPI in promoting children’s mental health by targeting changes in parenting behavior and parental self-efficacy in Malaysia. Findings from this study will be beneficial for policymakers to invest in parenting programs that could provide support to parents in enhancing their child’s overall development.

Clinical trial registration

[www.irct.ir], identifier [IRCT20211129053207N1].
A double-edged sword: The effects of R&D intensity and capitalization on institutional investment in entrepreneurial firms
Authors: Feng Yuan , Ma Chenyang , Wang Yushi , Ma Jiangshui
Published: September 2022

Studies show that research and development (R&D) may not always benefit entrepreneurial firms. This paper focuses on the double-edged effect of R&D activities on attracting institutional investment in entrepreneurial firms. Based on a panel dataset of 700 listed entrepreneurial firms in ChiNext, we document: (1) an inverted-U relationship between R&D intensity and future institutional investment, which we argue is evidence that institutional investors are concerned about R&D overinvestment; (2) an inverted-U relationship between R&D capitalization and future institutional investment, which we argue shows suspicion of the institutional investors towards high R&D capitalization. Furthermore, by splitting institutional investors into venture capitals (VCs) and non-venture capitals (non-VCs), we confirm that VCs have higher acceptance of both R&D intensity and capitalization as VCs have more expertise to alleviate a certain level of risks.
Preliminary evidence for the factor structure, concurrent validity, and construct validity of the Roommate Relationship Scale in a college sample
Authors: Willis Mairéad A. , Lane Sean P.
Published: September 2022

Roommate relationships are fundamental to the social environment of many emerging adults. However, no validated, widely used, measure of roommate relationship quality exists for examining the impact of these relationships on individual functioning and health. In this report, we present preliminary evidence of the factor structure, concurrent validity, and construct validity of the Roommate Relationship Scale (RRS) as a measure of roommate relationship quality using a sample of U.S. college students who participated in a multi-wave study. An exploratory factor analysis at the first wave, and confirmatory factor analyses (CFAs) with independent samples of new participants at each of two subsequent waves showed stable factor loadings and adequate fit. Moreover, the scale demonstrated good fit and reliability in a longitudinal multilevel CFA framework. The RRS significantly positively correlated with relationship length, self-esteem, extraversion, agreeableness, and conscientiousness, and negatively correlated with symptoms of anxiety and avoidant attachment style, indicating concurrent validity of the scale with respect to these constructs. Consistent with findings from other relationship types, self-reported RRS scores decrease longitudinally, both across and between semesters of academic life, indicating construct validity of the scale. We conclude that the RRS is useful for evaluating roommate relationship quality among U.S. college students, and hopefully beyond. Further research should validate the scale’s utility in other, more diverse, populations and refine its underlying generating psychological process.
What is effective classroom dialog? A comparative study of classroom dialog in Chinese expert and novice mathematics teachers’ classrooms
Authors: Zhao Wenjun , Ma Jing , Cao Yiming
Published: September 2022

Conducting effective classroom dialog is an important foundation for high-quality classrooms. This study investigates the characteristics of effective classroom dialog from the perspective of Chinese mathematics classrooms. Classroom videotapes from 40 expert and 33 novice teachers were selected from a national project and analyzed through a developed coding framework. Results showed that the dominant types of dialog in expert teachers’ classrooms were related to Basic Knowledge, Construction, Analysis, and Personal Information. Compared to novice teachers, expert teachers’ classrooms have a significantly lower proportion of dialog on Basic Knowledge and significantly higher proportions of dialog on Personal Information and Speculation. Based on expert teachers’ classrooms, the characteristics of effective classroom dialog in the Chinese context were discussed. The analytical framework for classroom dialog developed in this study could be a powerful tool for subsequent research. Suggestions are provided on increasing the effectiveness of classroom dialog.
Entrepreneurship education on entrepreneurial intention: The moderating role of the personality and family economic status
Authors: Liu Yiran , Li Min , Li Xin , Zeng Jingyi
Published: September 2022

This study investigates the impact of entrepreneurship education on college students’ entrepreneurial intentions, as well as the moderating effects of personality and family economic status on the relationship between entrepreneurship education and entrepreneurial intention, respectively. We tested our hypotheses using a sample of college students in Tianjin, China, and analyzed the data of 326 questionnaires containing validated measures. The results show that entrepreneurship education has a positive impact on college students’ entrepreneurial intentions; proactive personality negatively moderates this relationship; and family economic status positively moderates it. However, the moderating effect of narcissistic personality has not been verified. This study is unique and innovative as it brings new insights to this stream of literature by introducing the roles of the personality and family economic status in the relationship between entrepreneurship education and entrepreneurial intention. Our analysis provides important empirical evidence about the negative moderating effect of proactive personality and the positive moderating effect of family economic status on the relationship between entrepreneurship education and entrepreneurial intention, introducing insights into the heterogeneity of the effect of entrepreneurship education.
Exploring the impact of the COVID-19 pandemic in Euroleague Basketball
Authors: Paulauskas Rûtenis , Stumbras Mykolas , Coutinho Diogo , Figueira Bruno
Published: September 2022

The aim of this study was to understand how training and playing conditions during the COVID-19 pandemic affected the performance of Euroleague Basketball players. Using a non-participant observation analysis, the study compared the seasons before the lockdown (2018–2019 and 2019–2020; pre-pandemic) with the season after restart (2020–2021; pandemic). Paired t-tests and Wilcoxon tests were applied for variables with normal and non-normal distributions, respectively. The results revealed significant changes (p < 0.05) in several offensive and defensive performance-related variables during pandemic times (without attendance): free throw attempts, free throw percentage, turnovers, three-point attempt rate, fouls (small effect sizes, ESs), points, and possessions (trivial ES). The pre-pandemic HA (70%) significantly decreased after the lockdown, with games played with no crowd (∼51%; p = 0.018, large ES). The one-sample t-test showed that the HA after the COVID-19 interruption was not significantly greater than 50%, indicating that the HA did not endure during the pandemic condition. Although significant differences between home and away teams were found for most performance-related variables (excepting turnovers) in both pre-pandemic and pandemic conditions, variations of the relative HA were only significant for free throw attempts (large ES), points (medium ES), and turnovers (medium ES). The results of this study showed that performance variables were affected by the COVID-19 lockdown. Thus, these findings may help coaches, players, and referees to counteract unwanted competitive events and improve their overall performance, regardless of the contextual/situational circumstances encountered.
Care in the time of COVID: An interpretative phenomenological analysis of the impact of COVID-19 control measures on post-partum mothers’ experiences of pregnancy, birth and the health system
Authors: von Rieben Mikhayl A. , Boyd Leanne , Sheen Jade
Published: September 2022

Background

Findings suggest pandemic control measures have modified maternal health practices, compromising the quality of care provided to new and expectant mothers and interfering with their birthing experiences. For this reason, this study explored the lived experiences of post-partum Victorian mothers during the pandemic as well as the potential influence of control measures over their perceptions regarding the health system.

Methods

This study used a qualitative approach. Recruitment was conducted between May and June 2021, using both the Australian Breastfeeding Association’s social media pages and snowball recruitment. Interviews were semi-structured using open-ended questions relating to key themes. Seven Victorian post-partum mothers were identified and their transcripts analysed using Interpretative Phenomenological Analysis.

Results

Mothers described how unexpected changes to maternal care exacerbated feelings of uncertainty regarding pregnancy and birth. Mothers also differentiated between impacts by the health system and the role healthcare professionals played in moderating these effects. Whilst visitor restrictions provided some benefit, restrictions to familial and social support left many of the mothers feeling alone during their pregnancy and interfered with their immediate post-partum experience.

Conclusion

This study illustrates the importance of evidence-based practice in maternal care and provides insights for both health professionals and policy analysts in developing new or modifying existing guidelines that better balance the needs of expectant and post-partum mothers with pandemic control measures.
Economic analysis on the causes of mental health stress of enterprise employees based on emotional feature clustering
Authors: Li Benqing , Qiao Yajie
Published: September 2022

Emotional labor generally exists in organization members. Emotional labor will not only affect employees’ interpersonal relationships, but also affect employees’ mental health. Affected by many factors such as the economic environment, they often need to bear multiple pressures. The degree of stress is positively correlated with the depth of the development of the times and people’s education. As mental health research has become the frontier and hot spot in the field of psychology, the role of mental health in the process of employee creativity has been paid more and more attention. Therefore, this paper proposes a study on the causes of employees’ psychological stress based on emotional feature clustering. Based on the clustering of emotional characteristics, this paper analyzes the causes of employees’ mental health stress from an economic perspective. For teams with low level of team openness, with the improvement of team heterogeneity, team task performance shows a slight upward trend. It is clear from the experiment that when the number of experiments reaches 100, the task performance of high atmosphere level is 12.14, while the task performance of low atmosphere level is only 9.89. Therefore, the atmosphere of team employees is very important to team task performance. Through the cluster analysis of employees’ mental health characteristics, it not only increases employees’ spare time life, but also reduces employees’ daily contradictions. It eases the work pressure of employees, and becomes a platform for employees to improve their awareness and a promoter of harmonious employee relations.
How different advertising appeals (green vs. non-green) impact consumers' willingness to pay a premium for green agricultural products
Authors: Zheng Manhua , Tang Decong , Chen Jianhong , Zheng Qiujin , Xu Anxin
Published: September 2022

Green food has exceptional impacts in addressing food safety and environmental challenges. However, consumers' perception of green food is not substantial, which results in a decline in consumption intention. Since advertising appeals can play a bridging role in resolving information asymmetry. This study is based on self-construal theory, chooses green agricultural products images and text as experimental stimuli, and analyzes the interaction and influence mechanism between advertising appeals and consumers' willingness to pay a premium for green agricultural products through three sets of experimental studies. The findings demonstrate that self-construal and green agricultural product advertising appeals interact to influence consumers' willingness to pay a premium for green agricultural products. Green perceived value is more strongly influenced by matching dependent self-construal and green advertising appeals than non-green advertising appeals. Green perceived value plays a full mediating role in this interactive effect. Green agricultural products companies should adopt different advertising strategies according to the various categories of consumers to enhance consumers' green perceived value and increase the willingness to pay a premium.
Correlation research of susceptibility single nucleotide polymorphisms and the severity of clinical symptoms in attention deficit hyperactivity disorder
Authors: Xu Yunyu , Lin Shuangxiang , Tao Jiejie , Liu Xinmiao , Zhou Ronghui , Chen Shuangli , Vyas Punit , Yang Chuang , Chen Bicheng , Qian Andan , Wang Meihao
Published: September 2022

Objective

To analyze the correlation between susceptibility single nucleotide polymorphisms (SNPs) and the severity of clinical symptoms in children with attention deficit hyperactivity disorder (ADHD), so as to supplement the clinical significance of gene polymorphism and increase our understanding of the association between genetic mutations and ADHD phenotypes.

Methods

193 children with ADHD were included in our study from February 2017 to February 2020 in the Children’s ADHD Clinic of the author’s medical institution. 23 ADHD susceptibility SNPs were selected based on the literature, and multiple polymerase chain reaction (PCR) targeted capture sequencing technology was used for gene analysis. A series of ADHD-related questionnaires were used to reflect the severity of the disease, and the correlation between the SNPs of specific sites and the severity of clinical symptoms was evaluated. R software was used to search for independent risk factors by multivariate logistic regression and the “corplot” package was used for correlation analysis.

Results

Among the 23 SNP loci of ADHD children, no mutation was detected in 6 loci, and 2 loci did not conform to Hardy-Weinberg equilibrium. Of the remaining 15 loci, there were 9 SNPs, rs2652511 (SLC6A3 locus), rs1410739 (OBI1-AS1 locus), rs3768046 (TIE1 locus), rs223508 (MANBA locus), rs2906457 (ST3GAL3 locus), rs4916723 (LINC00461 locus), rs9677504 (SPAG16 locus), rs1427829 (intron) and rs11210892 (intron), correlated with the severity of clinical symptoms of ADHD. Specifically, rs1410739 (OBI1-AS1 locus) was found to simultaneously affect conduct problems, control ability and abstract thinking ability of children with ADHD.

Conclusion

There were 9 SNPs significantly correlated with the severity of clinical symptoms in children with ADHD, and the rs1410739 (OBI1-AS1 locus) may provide a new direction for ADHD research. Our study builds on previous susceptibility research and further investigates the impact of a single SNP on the severity of clinical symptoms of ADHD. This can help improve the diagnosis, prognosis and treatment of ADHD.
Fast identification and quantification of c-Fos protein using you-only-look-once-v5
Authors: Pang Na , Liu Zihao , Lin Zhengrong , Chen Xiaoyan , Liu Xiufang , Pan Min , Shi Keke , Xiao Yang , Xu Lisheng
Published: September 2022

In neuroscience, protein activity characterizes neuronal excitability in response to a diverse array of external stimuli and represents the cell state throughout the development of brain diseases. Importantly, it is necessary to characterize the proteins involved in disease progression, nuclear function determination, stimulation method effect, and other aspects. Therefore, the quantification of protein activity is indispensable in neuroscience. Currently, ImageJ software and manual counting are two of the most commonly used methods to quantify proteins. To improve the efficiency of quantitative protein statistics, the you-only-look-once-v5 (YOLOv5) model was proposed. In this study, c-Fos immunofluorescence images data set as an example to verify the efficacy of the system using protein quantitative statistics. The results indicate that YOLOv5 was less time-consuming or obtained higher accuracy than other methods (time: ImageJ software: 80.12 ± 1.67 s, manual counting: 3.41 ± 0.25 s, YOLOv5: 0.0251 ± 0.0003 s, p < 0.0001, n = 83; simple linear regression equation: ImageJ software: Y = 1.013 × X + 0.776, R2 = 0.837; manual counting: Y = 1.0*X + 0, R2 = 1; YOLOv5: Y = 0.9730*X + 0.3821, R2 = 0.933, n = 130). The findings suggest that the YOLOv5 algorithm provides feasible methods for quantitative statistical analysis of proteins and has good potential for application in detecting target proteins in neuroscience.
Higher brain structural heterogeneity in schizophrenia
Authors: Fang Keke , Wen Baohong , Niu Lianjie , Wan Bo , Zhang Wenzhou
Published: September 2022

As a highly heterogeneous disorder, schizophrenia shows notable interindividual variation in clinical manifestations. On that account, an increasing number of studies begin to examine the interindividual variability in neuroimaging characterization in schizophrenia. However, whether schizophrenia demonstrates higher interindividual morphological variability than health controls (HCs) remains unknown. T1-weighted anatomical images were obtained from patients with schizophrenia (n = 61) and matched HCs (n = 73). For each subject, voxel-wise gray matter volume was obtained using voxel-based morphometry analysis. We first inquired whether patients with schizophrenia showed higher interindividual structural variation than HCs using the person based similarity index (PBSI). Then, we examined differences of voxel-wise morphological coefficient of variation (CV) between schizophrenia and HCs. To further associate identified regions showing higher variability in schizophrenia with cognitive/functional processes, functional annotation was performed. Patients with schizophrenia exhibited lower PBSIs than matched HCs, suggesting higher interindividual morphological variability in schizophrenia. The following results showed that patients with schizophrenia exhibited higher CVs than HCs in distributed brain regions including the striatum, hippocampus, thalamus, parahippocampa gyrus, frontal gyrus, and amygdala. Brain regions showing higher CVs in schizophrenia were significantly implicated in affective, incentive and reward related terms. These results provide a new insight into the high clinical heterogeneity and facilitate personalized diagnose and treatment in schizophrenia.
Assessment of Canadian perinatal mental health services from the provider perspective: Where can we improve?
Authors: Hicks Laurel M. , Ou Christine , Charlebois Jaime , Tarasoff Lesley , Pawluski Jodi , Roos Leslie E. , Hooykaas Amanda , Fairbrother Nichole , Carter Michelle , Tomfohr-Madsen Lianne
Published: September 2022

Purpose

Perinatal mental health disorders are common, and rates have increased during the COVID-19 pandemic. It is unclear where providers may improve perinatal mental health care, particularly in countries lacking national guidelines, such as Canada.

Methods

A cross-sectional survey of perinatal health providers was conducted to describe the landscape of perinatal mental health knowledge, screening, and treatment practices across Canada. Providers were recruited through listservs, social media, and snowball sampling. Participants completed an online survey that assessed their perinatal mental health training, service provision types, their patient wait times, and treatment barriers, and COVID-19 pandemic-related impacts.

Results

A total of 435 providers completed the survey, including physicians, midwives, psychologists, social workers, nurses, and allied non-mental health professionals. Most (87.0%) did not have workplace mandated screening for perinatal mental illness but a third (66%) use a validated screening tool. Many (42%) providers stated their patients needed to wait more than 2 months for services. More than half (57.3%) reported they did not receive or were unsure if they received specialized training in perinatal mental health. Most (87.0%) indicated there were cultural, linguistic, and financial barriers to accessing services. Over two-thirds (69.0%) reported the COVID-19 pandemic reduced access to services.

Conclusion

Survey findings reveal significant gaps in training, screening tool use, and timely and culturally safe treatment of perinatal mental health concerns. There is critical need for coordinated and nationally mandated perinatal mental health services in Canada to improve care for pregnant and postpartum people.
Storytelling and training to advance individual recovery skills (STAIRS). A feasibility study of a blended program to support personal recovery among patients with a major depressive disorder in remission
Authors: Wedema David , Siero Joanieke , Korevaar Eliza L. , Wardenaar Klaas J. , Alma Manna A. , Schoevers Robert A.
Published: September 2022

Because major depressive disorder (MDD) has a strong negative impact on patients' lives, well–designed treatment programs are needed that address the lasting effects of MDD. Previous work has shown that such programs should not only focus on symptomatic recovery, but also on the subsequent personal recovery process. Currently, few programs with this specific focus exist. Therefore, this study aimed to assess the feasibility of a newly developed blended program to support the personal recovery process of MDD patients: Storytelling and Training to Advance Individual Recovery Skills (STAIRS). STAIRS is a program using peer support and guidance by experts by experience and clinicians, which can be added to regular depression treatment when symptomatic recovery is almost reached. Topics addressed in this program are: (1) effects of depression and treatment; (2) structure; (3) (self) stigma; (4) self-image; (5) meaning of life; (6) connection to others; (7) physical health; (8) relaxation; and (9) preventing relapse. Experiences with the STAIRS program were collected from five participating patients with questionnaires and a focus-group interview, as well as from four trainers using semi-structured interviews. Participants valued the topics addressed in STAIRS, the used working methods, the presence of an expert by experience and the ability to share experiences with peers. The use of an online platform and the involvement of others is seen as potentially supportive but turned out to be more challenging. Perceived effects of STAIRS include positive changes in participants' daily lives and their contacts with others. Overall, the results indicate that when implemented accessibly, STAIRS is a promising and feasible program to foster personal recovery among patients recovering from MDD.
The impact of cannabis legalization for recreational purposes on youth: A narrative review of the Canadian experience
Authors: Rubin-Kahana Dafna Sara , Crépault Jean-François , Matheson Justin , Le Foll Bernard
Published: September 2022

Cannabis legalization for non-medical purposes (subsequently referred to as “cannabis legalization” or “legalization”) took place in Canada in October 2018. One of the federal government's stated goals with cannabis legalization was to protect Canadian youth from cannabis-related harms. The main objective of this narrative review is to describe the impact of cannabis legalization on Canadian youth. To that end, we discuss the regulation of the Canadian cannabis market, outline changes in the epidemiology and parameters of cannabis use (modes of use, potency of cannabis) among youth, and discuss prevention and education initiatives related to cannabis. The Canadian model differs from other jurisdictions that legalized recreational cannabis use, especially with regard to a higher degree of government regulation of the cannabis market. Another difference is the development and endorsement of lower-risk cannabis use guidelines to educate the public and health professionals. The results available for this review cover only 3 years post-legalization. Cannabis legalization in Canada brought an apparent increase in use among Canadian older than 25. However, results for youth are mixed, with the majority of studies showing no pronounced increase. Notably, the trend of a decrease in adolescents' cannabis use seen pre-legalization may have reversed. Emerging evidence also suggests that cannabis-related hospitalizations and emergency department visits among Canadian youth may have increased due to cannabis legalization. Data about changes in the age of initiation, the influence of legalization on sex and gender, and race/ethnicity are limited, with evidence suggesting that the age of initiation slightly increased. So far, there is limited data about the impact of cannabis legalization on Canadian youth. Further long-term monitoring and research to assess the effects of cannabis legalization on Canadian youth.
Resilience mediates the influence of hope, optimism, social support, and stress on anxiety severity among Chinese patients with cervical spondylosis
Authors: Chu Yuying , Zhang Yuqiang , Wang Suyan , Dai Hongliang
Published: September 2022

Objective

Cervical spondylosis (CS) is a potential stressor threatening mental health among affected individuals. This study was to analyze resilience level and associated factors among cervical spondylosis (CS) patients, and to explore the underlying mechanism of anxiety based on resilience-focused psychological variables.

Methods

Resilience Scale-14 (RS-14), Zung Self-Rating Anxiety Scale (SAS), Herth Hope Index (HHI), Revised Life Orientation Test (LOT-R), Multidimensional Scale of Perceived Social Support (MSPSS), Perceived Stress Scale-10 (PSS-10) were used in this cross-sectional investigation among 250 CS patients.

Results

The score of resilience was 65.58 ± 16.14. Hierarchical linear regression analysis revealed that hope, optimism, perceived social support, perceived stress, and whether having comorbid chronic diseases were the independent associates of resilience among CS patients, which explained 63.9% of the total variance. The structural equation model showed that hope, optimism, perceived social support and perceived stress affected anxiety via resilience, and hope and optimism also had direct effects on anxiety.

Conclusion

Chinese patients with CS had moderate level of mental resilience, which was independently related to hope, optimism, perceived social support, perceived stress, and whether having comorbid chronic diseases. Resilience played a mediating role between various psychological variables and anxiety. Improving the level of resilience, hope, optimism and perceived social support and reducing the level of perceived stress are important strategies to reduce anxiety level. Relevant healthcare professionals should put more focus on the mental problems of Chinese CS patients and help maintain good psychological status by improving their resilience and associated psychological variables thereof.
Pilot study of peripheral blood chemokines as biomarkers for atrial fibrillation-related thromboembolism and bleeding in elderly patients
Authors: Tai Meihui , Shi Haiyan , Wang Hao , Ma Xiao , Gao Meng , Chang Qing , Li Fang , Zeng Qiang , Shi Yang , Guo Yutao
Published: September 2022

Background

The scoring systems currently used to identify the potential for thrombosis and bleeding events in high-risk atrial fibrillation patients have certain limitations. The aim of this pilot study was to identify inflammatory chemokines with potential utility as sensitive biomarkers for the risk of thrombosis and bleeding in elderly patients with non-valvular atrial fibrillation.

Methods

From January 1, 2014, to December 31, 2017, 200 consecutive elderly patients with atrial fibrillation (average age: 87.6 ± 7.7 years) were enrolled and followed up for 2 years to observe thromboembolic (arterial and venous) and bleeding events. Serum was collected upon enrollment, and the baseline levels of 27 chemokines were analyzed. During the 2-year follow-up, 12 patients were lost to follow-up. Among the 188 patients, there were 32 cases (17.0%) of AF-related thrombosis, 36 cases (19.1%) of arterial thrombosis, and 35 cases (18.6%) of major bleeding events.

Results

Among 188 patients, 30 patients without clinical events (control group), 23 with arterial thrombosis, 15 with atrial fibrillation-related venous thromboembolism, and 12 with major bleeding were selected and randomly matched to compare chemokine levels. The baseline levels of interleukin-6, interleukin-10, vascular cell adhesion molecule-1, chemokine C-C-motif ligand, B-lymphocyte chemoattractant 1, interleukin-4, E-selectin, fractalkine, C-X-C motif chemokine 12, and granulocyte chemotactic protein 2 were found to differ statistically among the four groups (p < 0.05). Compared with that in the control group, the level of interleukin-4 in patients with atrial fibrillation-related thrombosis, arterial thrombosis, or major bleeding increased by 53-fold (0.53 vs. 0.01 pg/ml), 17-fold (0.17 vs. 0.01 pg/ml), and 19-fold (0.19 vs. 0.01 pg/ml), respectively. Compared with that in the control group, the level of interleukin-6 in patients with arterial thrombosis increased by six-fold (39.78 vs. 4.98 pg/ml).

Conclusions

Among elderly patients with atrial fibrillation at high risk of thromboembolism and bleeding, the baseline levels of interleukin-6, interleukin-4, and E-selectin were significantly increased in those that experienced thrombosis and bleeding events during the 2-year follow-up, indicating that these chemokines may serve as potential biomarkers for an increased risk of thrombosis and bleeding in this population.

Clinical trial registration number

ChiCTR-OCH-13003479.
A Time-Series Study for Effects of Ozone on Respiratory Mortality and Cardiovascular Mortality in Nanchang, Jiangxi Province, China
Authors: Wu Hao , Lu Keke , Fu Junjie
Published: September 2022

Objective

Most evidence comes from studies show that ambient ozone(O3) pollution has become a big issue in China. Few studies have investigated the impact of ozone spatiotemporal patterns on respiratory mortality and cardiovascular mortality in Nanchang city. Thus, this study aimed to explore the health effect of ozone exposure on respiratory mortality and cardiovascular mortality in Nanchang, Jiangxi Province.

Methods

Using the daily mortality data, atmospheric routine monitoring data and meteorological data in Nanchang from 2014 to 2020, we performed a generalized additive model (GAM) based on the poisson distribution in which time-series analysis to calculate the risk correlation between respiratory mortality and cardiovascular mortality and ozone exposure level (8h average ozone concentration, O3-8h). Besides, analyses were also stratified by season, age and sex.

Results

In the single-pollutant model, for every 10 μg/m3 increase in ozone, respiratory mortality increased 1.04% with 95% confidence interval (CI) between 0.04 and 1.68%, and cardiovascular mortality increased 1.26% (95%CI: 0.68 ~ 1.83%). In the multi-day moving average lag model, the mortality of respiratory diseases and cardiovascular diseases reached a relative risk peak on the cumulative lag5 (1.77%,95%CI: 0.99 ~ 2.57%) and the cumulative lag3 (1.68%,95%CI: 0.93 ~ 2.45%), respectively. The differences were statistically significant (P < 0.05). Results of the stratified analyses showed the effect value of respiratory mortality in people aged ≥65 years was higher than aged <65 years, whereas the greatest effect of cardiovascular mortality in people aged <65 years than aged ≥65 years. Ozone had a more profound impact on females than males in respiratory diseases and cardiovascular diseases. In winter and spring, ozone had a obvious impact on respiratory mortality, and effects of ozone pollution on cardiovascular mortality were stronger in summer and winter. There was a statistically significant difference of respiratory mortality in winter and spring and of cardiovascular mortality in summer and winter (P < 0.05).

Conclusions

In the long run, the more extreme the pollution of ozone exposure, the higher the health risk of residents' respiratory mortality and cardiovascular mortality. Therefore, the government should play an important role in the prevention and control ways of decreasing and eliminating the ozone pollution to protect the resident's health. The findings provide valuable data for further scientific research and improving environmental policies in Nanchang city.
Felt Stigma and Its Underlying Contributors in Epilepsy Patients
Authors: Mao Lingyan , Wang Keying , Zhang Qianqian , Wang Jing , Zhao Yanan , Peng Weifeng , Ding Jing
Published: September 2022

Objective

To explore the correlated clinical and psychological factors of stigmatization and investigate the relationship between stigma and white matter abnormalities in epilepsy patients.

Methods

Stigmatization was obtained by a three-item stigma scale in 256 epilepsy patients with genetic or unknown etiology. Personality and quality of life (QOL) were assessed by Eysenck Personality Questionnaire (EPQ) and QOL-31 questionnaire respectively. One hundred and fourteen of them were performed Hamilton Depression Scale-17 (HAMD) and scanned with diffusion tensor imaging in 3T MRI. Fractional anisotropy (FA) values of frontotemporal contact fibers were calculated.

Results

There were about 39.8% patients felt stigma, with the highest score (Score 3) in 8.2% (21/256). Stigma scores were significantly negatively correlated with education (P < 0.01), age of onset (P < 0.05), extraversion score of EPQ (P < 0.01), total and all the subscale QOL scores (P < 0.001), and positively correlated with duration (P < 0.01), HAMD score (P < 0.001), neuroticism score of EPQ (P < 0.001). We found negative correlation between stigma scores and FA values of right superior longitudinal fasciculus and left cingulum (P < 0.05). Logistic regression results showed that FA value of left cingulum (P = 0.011; OR = 0.000), social function (P = 0.000; OR = 0.935) of QOL, and neuroticism score of EPQ (P = 0.033; OR = 1.123) independently correlated to felt stigma.

Conclusion

Felt stigma in epilepsy patients was found to be correlated with neuroticism, depression, and deficient social function of QOL, which might be predisposed by the impairment of the left cingulum. Our results provide preliminary evidence for the underlying neural circuits in stigmatization.
Gender differences in medical errors among older patients and inequalities in medical compensation compared with younger adults
Authors: Liu Paicheng , Yang Yuxuan , Cheng Jianxin
Published: September 2022

Background

Despite growing evidence focusing on health inequalities in older adults, inequalities in medical compensation compared with younger adults and gender disparities of medical errors among older patients have received little attention. This study aimed to disclose the aforementioned inequalities and examine the disparities in medical errors among older patients.

Methods

First, available litigation documents were searched on “China Judgment Online” using keywords including medical errors. Second, we compiled a database with 5,072 disputes. After using systematic random sampling to retain half of the data, we removed 549 unrelated cases. According to the age, we identified 424 and 1,563 cases related to older and younger patients, respectively. Then, we hired two frontline physicians to review the documents and independently judge the medical errors and specialties involved. A third physician further considered the divergent results. Finally, we compared the medical compensation between older and younger groups and medical errors and specialties among older patients.

Results

Older patients experienced different medical errors in divergent specialties. The medical error rate of male older patients was over 4% higher than that of females in the departments of general surgery and emergency. Female older patients were prone to adverse events in respiratory medicine departments and primary care institutes. The incidence of insufficient implementation of consent obligation among male older patients was 5.18% higher than that of females. However, females were more likely to suffer adverse events at the stages of diagnosis, therapy, and surgical operation. The total amount of medical compensation obtained by younger patients was 41.47% higher than that of older patients.

Conclusions

Except for the common medical errors and departments involved, additional attention should be paid to older patients of different genders according to the incidence of medical errors. Setting up the department of geriatrics or specialist hospitals is also an important alternative to improve patient safety for older people. Furthermore, there may be inequality in medical compensation in older patients due to the tort liability law of China.
Multimorbidity resilience and health behaviors among older adults: A longitudinal study using the Canadian Longitudinal Study on Aging
Authors: Wister Andrew , Li Lun , Whitmore Carly , Ferris Jennifer , Klasa Katarzyna , Linkov Igor
Published: September 2022

Objective

There has been a growing interest in examining why some individuals adapt and bounce back from multimorbidity (resilience) better than others. This paper investigates the positive role of protective health behaviors on multimorbidity resilience (MR) among older adults focusing on older persons with two or more concurrent chronic conditions, and separately for three multimorbidity chronic illness clusters.

Methods

Using Baseline and Follow-up One data from the Comprehensive Cohort of the Canadian Longitudinal Study on Aging, we studied 10,628 participants aged 65 years and older who reported two or more of 27 chronic conditions, and three multimorbidity clusters: Cardiovascular/metabolic, Musculoskeletal, and Mental health. Associations between health behaviors and MR were evaluated using Linear Mixed Models, adjusting for socio-demographic, social/environmental, and illness context social determinants of health.

Results

Among older adults with two or more illnesses, smoking, satisfaction with sleep, appetite, and skipping meals were associated with MR in the expected direction. Also, obesity (compared to normal weight) and skipping meals showed longitudinal interaction effects with survey wave. Most of the results were replicated for the physical multimorbidity clusters (Cardiovascular/metabolic and Musculoskeletal) compared to the full 2+ multimorbidity analyses; however, for the Mental health cluster, only satisfaction with sleep was supported as a lifestyle predictor of MR.

Discussion

Several modifiable health behaviors identified in the broader health and aging literature are important in affecting levels of multimorbidity resilience in older age. These factors are important strength-based areas to target. Additionally, several social determinants of health are also supported and parallel research on multimorbidity risk. The effects of lifestyle factors for resilience among older adults is dependent on the type of multimorbidity measured. We conclude that the results have significant public health, program intervention, and clinical implications for healthy aging among persons coping with multimorbidity.