bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on Astronomical Cycle Identification and Environmental Response Characteristics of Lacustrine Deep-Water Fine-Grained Sedimentary Rocks: A Case Study of the Lower Submember of Member 3 of Shahejie Formation in Well Fanye-1 of Dongying Sag, Bohai Bay Basin, China
Authors: Yu Ledan , Peng Jun , Xu Tianyu , Wang Yubin , Han Haodong
Published: June 2021

With the further exploration and development of shale oil and gas, cycle division of fine-grained sedimentary rock strata has been increasingly highly focused on by scholars. Owing to the application of the theory of classical sequence stratigraphy based on water depth changes and its technical methods being unsatisfactory in the isochronous division and correlation of deep-water fine-grained sedimentary strata, the cycle division of fine-grained sedimentary rock strata has always been a difficult point in the study of sequence stratigraphy. In this paper, the Milankovitch cycle recorded from the study interval and the environment response characteristics were studied, with the lacustrine shale in the lower third submember of the Paleogene Shahejie Formation (lower Es3 submember) in Well Fanye-1 of the Dongying sag, Bohai Bay Basin, as the object of study, by such technical means as thin section identification and X-ray whole rock diffraction, based on such data as logging data and geochemistry, combining the methods of spectral analysis, wavelet transform, and modulus extremum. The results showed that the stratigraphic cycle thicknesses caused by long eccentricity, short eccentricity, and obliquity periods were 38.95 m, 12.98 m, and 4.10 m, respectively, and a total of 16 short eccentricity periods and 4.5 long eccentricity periods were identified in the study interval. Thus, it was further calculated that the sedimentation time was approximately 1.905 Ma, and the average sedimentation rate was estimated to be 0.105 m/ka. Studies have shown that the sedimentary environment of lacustrine fine-grained sedimentary rocks is controlled by the astronomical period, based on which the climate as a whole changes from relatively dry and cold to warm and wet when the eccentricity increases. The identification of the Milankovitch cycle of the lacustrine fine-grained sedimentary strata will provide references for the study of high frequency sequence and the division of high-resolution sequence strata, which can effectively solve the scientifically difficult isochronous division and correlation of lacustrine shale strata.
A Damage Constitutive Model of Rock Subjected to Freeze‐Thaw Cycles Based on Lognormal Distribution
Authors: Lin Hang , Liang Linyuan , Chen Yifan , Cao Rihong
Published: June 2021

The constitutive model of rock is closely connected with the mechanical properties of rock. To achieve a more accurate quantitative analysis of the mechanical properties of rock after the action of freeze‐thaw cycles, it is necessary to establish the constitutive models of rock subjected to freeze‐thaw cycles from the view of rock damage. Based on the assumption of rock couple damage, this study established a statistical damage constitutive model of rock subjected to freeze‐thaw cycles by combining the lognormal distribution, which is commonly used in engineering reliability analysis, and the strain strength theory. Then, the coordinates and derivative at the peak of the stress‐strain curve of the rock after the action of freeze‐thaw cycles were obtained through experiments to solve the statistical distribution parameters με and S of the model, whereafter, the theoretical curves by the established model were compared with the experimental curves to verify the validity of it, which shows a great agreement. Finally, the sensitivity analysis of the statistical distribution parameters was implemented. The results indicate that με reflects the strength of the rock, which shows a positive relation, and S stands for the brittleness of the rock, which shows a negative relation.
Privacy‐Preserving Federated Learning Framework with General Aggregation and Multiparty Entity Matching
Authors: Zhou Zhou , Tian Youliang , Peng Changgen
Published: June 2021

The requirement for data sharing and privacy has brought increasing attention to federated learning. However, the existing aggregation models are too specialized and deal less with users’ withdrawal issue. Moreover, protocols for multiparty entity matching are rarely covered. Thus, there is no systematic framework to perform federated learning tasks. In this paper, we systematically propose a privacy‐preserving federated learning framework (PFLF) where we first construct a general secure aggregation model in federated learning scenarios by combining the Shamir secret sharing with homomorphic cryptography to ensure that the aggregated value can be decrypted correctly only when the number of participants is greater than t. Furthermore, we propose a multiparty entity matching protocol by employing secure multiparty computing to solve the entity alignment problems and a logistic regression algorithm to achieve privacy‐preserving model training and support the withdrawal of users in vertical federated learning (VFL) scenarios. Finally, the security analyses prove that PFLF preserves the data privacy in the honest‐but‐curious model, and the experimental evaluations show PFLF attains consistent accuracy with the original model and demonstrates the practical feasibility.
Study on Surrounding Rock Structure Evolution Characteristics and Roof Control Techniques of the Retained Roadway Formed by Roof Cutting in Inclined Coal Seams
Authors: Yu Guangyuan , Wang Jiong , Ren Jianjun , Hu Jinzhu , Pan Zhifu , Wang Delu , Ming Wei
Published: June 2021

To control the roof during gob‐side entry retaining by roof cutting in inclined coal seams, the retained gob‐side roadway is zoned based on the mechanical principle and technological process of no‐pillar mining with gob‐entry retention. A simplified mechanical model for surrounding rocks in different subzones was established by using theoretical analysis and numerical simulation to attain the demand for the support resistance and deformation of the roof in different subzones. According to load and deformation characteristics of the roof and mechanical characteristics of NPR cables, single props, and a sliding‐type gangue‐retaining structure formed by U‐shaped steel inserts, the supporting systems for roadways in different subzones and the constitutive model thereof were established. On this basis, the action of the supporting system was analysed and a field test was performed. The results show that the supporting system undergoes three stages of behaviour, i.e., pressure growth, yielding under constant pressure, and stabilisation during whole entry retention. It can guarantee the collaborative deformation of the supporting systems with the roof on the premise of constant support resistance, thus satisfying the requirement for roadway protection. The roadway 150 m back from the working face is stable, and the final convergence between the roof and floor of the retained entry is 257 mm, showing a favourable entry‐retention effect.
[Retracted] Combined GNSS/SLAM‐Based High Accuracy Indoor Dynamic Target Localization Method
Authors: Zhang Xiaona , Zhang Shufang , Li Qiaosong , Wang Xin , Sun Shujing
Published: June 2021

As the indoor dynamic target localization does not detect and repair the circumferential jump value in time, which leads to large position and attitude errors and low‐velocity stability, a combined Global Navigation Satellite System/Simultaneous Localization and Mapping‐ (GNSS/SLAM‐) based high‐precision indoor dynamic target localization method is proposed. The method uses Empirical Mode Decomposition (EMD) to decompose the noisy signal, obtains the noise energy as the dominant mode from the decomposed components, extracts the useful signal energy as the main dividing point, removes the high‐frequency signal, constructs the low‐frequency component to realize low‐pass filtering and denoising, selects a suitable threshold processing function to make the high‐frequency signal component retain the detailed signal effectively to realize high‐frequency component denoising, detects and fixes the circumferential jump of the observed data, and detects and fixes the circumferential jump of each frequency. The indoor dynamic target positioning method is established by combining GNSS/SLAM to achieve high accuracy target positioning. The experimental results show that the position and attitude errors are small, and the velocity is stable, which indicates that the position information is closer to the dynamic target, i.e., the target positioning is more accurate. To address the problems of scale drift and frequent initialization due to environmental factors in monocular vision SLAM, an Ultra Wideband (UWB)/vision fusion localization model that takes into account the scale factor is proposed, which can give full play to the complementary characteristics between UWB and vision; solve the problems of visual initialization, scale ambiguity, and absolute spatial reference; and improve UWB localization accuracy and localization frequency as well as reducing the number of base stations. The model can reliably achieve 0.2 m accuracy in indoor environments with sparse texture or frequent light changes.
A Review of the Research and Development of High‐Frequency Measurement Technologies Used for Nonlinear Dynamics of Drillstring
Authors: Li Lixin , Wang Jin , Yu Yingmei , Xing Yifei , Zhang Fengyan , Zhang Yi , Li Yanyan
Published: June 2021

High‐frequency measurements can provide much more new insights for drillstring dynamics compared to traditional instruments, leading to a new realm of understanding of drillstring behaviors in great detail than before. In this paper, data acquisition tools with high‐frequency sample rates and the data processing are introduced. Based on high‐frequency data, progress of drilling dynamics is summarized, including new understandings of low‐frequency drillstring dynamics, high‐frequency torsional oscillations (HFTOs), and high‐frequency axial oscillations (HFAOs) and new findings for the coupling of vibrations and motions, as well as models and simulation methods to deeply comprehend high‐frequency dynamics of drillstring. High‐frequency measurements have been used for enabling drillers to improve drill performance, especially for field decision making, BHA selection, and bit design, usually through the ways of minimizing vibrations to obtain high‐efficient drilling conditions, the high‐frequency response near bit can also be used for lithology identification during drilling. Though there still exists a gap between research perspective and drilling practice, the industry of high‐frequency measurements has gotten off a good start, which has huge potential to avoid nonproductive time thereupon reducing drilling cost in the future.
New Markers of Platelet Activation and Reactivity and Oxidative Stress Parameters in Patients Undergoing Coronary Artery Bypass Grafting
Authors: Vukicevic Petar , Klisic Aleksandra , Neskovic Vojislava , Babic Luka , Mikic Aleksandar , Bogavac-Stanojevic Natasa , Matkovic Milos , Putnik Svetozar , Aleksic Nemanja , Kotur-Stevuljevic Jelena
Published: June 2021

Objective. Recent studies have shown that the red cell distribution width‐ (RDW‐) to‐platelet (PLT) count ratio (i.e., RPR) and the mean platelet volume (MPV)/PLT ratio (i.e. MPR) are more sensitive markers of atherosclerosis‐connected risk than RDW and PLT alone. The present study is aimed at investigating the oxidative stress status and these two new markers of platelet activation in two different heart surgery modalities: cardiopulmonary bypass (CPB) and off‐pump coronary artery bypass (OPCAB). We also aimed to test the possible relationship between RPR and MPR, respectively, and the severity and complexity of atherosclerotic plaque, measured as Syntax Score. Patients and Methods. A total of 107 patients encompassed this prospective study (i.e., 60 patients in CPB group and 47 patients in OPCAB). Blood samples were drawn at several time intervals: before skin incision (t1), immediately after intervention (t2), 6 h (t3), 24 h (t4), 48 h (t5), and 96 h after cessation of the operation (t6). Results. The values of RPR and MPR were similar in CPB and OPCAB before surgery and started to rise in t2 (i.e., immediately after the intervention). This increase lasted to t5 (i.e., 48 hours after the intervention), when it became the highest. After that, both markers started to regress about the 96th hour after the beginning of surgery. Nominal values of both indices were higher in CPB than in OPCAB in all study points after the surgery. Furthermore, a significantly higher level of antioxidative parameters (i.e., total sulfhydryl groups and paraoxonase 1) in the OPCAB group compared to the CPB group was noted at t5 study point (i.e., 48 hours after the surgery), whereas no significant difference was noted in prooxidant levels (i.e., lipid hydroperoxides and advanced oxidation protein products) between these groups at this study point. MPR and RPR correlated positively with Syntax Score at several study points after the surgery completion. Syntax Score, MPR, and RPR showed good clinical accuracy in surgery‐related complication prediction ((AUC = 0.736), 95th CI (0.616‐0.856), P = 0.003)). Conclusion. When combined, MPV, RDW, and platelet count, such as MPR and RPR, could be good predictors of coronary artery disease status, regarding the aspect of joint inflammation, oxidative stress, and thrombosis.
Elite Adaptive Simulated Annealing Algorithm for Maximizing the Lifespan in LSWSNs
Authors: Zhou Jie , Jia Wenxian , Liu Menghan , Xu Mengying
Published: June 2021

Large‐scale wireless sensor networks (LSWSNs) are currently one of the most influential technologies and have been widely used in industry, medical, and environmental monitoring fields. The LSWSNs are composed of many tiny sensor nodes. These nodes are arbitrarily distributed in a certain area for data collection, and they have limited energy consumption, storage capabilities, and communication capabilities. Due to limited sensor resources, traditional network protocols cannot be directly applied to LSWSNs. Therefore, the issue of maximizing the LSWSNs’ lifetime by working with duty cycle design algorithm has been extensively studied in this paper. Encouraged by annealing algorithm, this work provides a new elite adaptive simulated annealing (EASA) algorithm to prolong LSWSNs’ lifetime. We then present a sensor duty cycle models, which can make sure the full coverage of the monitoring targets and prolong the network lifetime as much as possible. Simulation results indicate that the network lifetime of EASA algorithm is 21.95% longer than that of genetic algorithm (GA) and 28.33% longer than that of particle swarm algorithm (PSO).
A Mobility‐Aware and Sociality‐Associate Computation Offloading Strategy for IoT
Authors: Lu Yanfei , Chen Zengzi , Gao Qinghe , Jing Tao , Qian Jin
Published: June 2021

Mobile edge computing, a promising paradigm, brings services closer to a user by leveraging the available resources in an edge network. The crux of MEC is to reasonably allocate resources to satisfy the computing requirements of each node in the network. In this paper, we investigate the service migration problem of the offloading scheme in a power‐constrained network consisting of multiple mobile users and fixed edge servers. We propose an affinity propagation‐based clustering‐assisted offloading scheme by taking into account the users’ mobility prediction and sociality association between mobile users and edge servers. The clustering results provide the candidate edge servers, which greatly reduces the complexity of observing all edge servers and decreases the rate of service migration. Besides, the available resource of candidate edge servers and the channel conditions are considered to optimize the offloading scheme to guarantee the quality of service. Numerical simulation results demonstrate that our offloading strategy can enhance the data processing capability of power‐constrained networks and reach computing load balance.
Equivalent Continuum Coupling-Based Slope Stability Analysis of Zhouning Pumped Storage Power Station
Authors: Lin Jinhong , Zhu Yongsheng , Hou Jing , Pan Bing , Chu Weijiang , Huang Wenhong
Published: June 2021

A 3D equivalent continuum coupling analysis of the slope of the Zhouning pumped storage power station was proposed in this study. Firstly, the hydraulic properties of rock mass, groundwater, and deformation mechanism under high-frequency fluctuations of the water level are analyzed. Secondly, the three-dimensional Digital Terrain Model (DTM) with surface image information was established by digital photogrammetry technology for cataloging field fracture information. Third, stress-seepage coupling simulation using a hybrid grid approach and the FLAC3D equivalent continuum model was implemented. The results show that the permeability of rock mass is stress-dependent and anisotropic, and the direction of maximum principal permeability of both bank slopes is approximately parallel to the river. Slope deformations induced by impoundment during the operation period are the superposition results of two mechanisms, referred to as “mattress effect” and “swelling effect.” Attention should be paid to the tensile strength of the rock mass during operation.
Application of Deep Learning Algorithms in Determination of Trace Rare Earth Elements of Cerium Group in Rocks and Minerals
Authors: Ma Sumin , Huang Wenhui
Published: June 2021

Since the breakthrough of deep learning in object classification in 2012, extraordinary achievements have been made in the field of target detection, but the high time and space complexity of the target detection network based on deep learning has hindered the technology from application in actual product. To solve this problem, first of all, this paper uses the MobileNet classification network to optimize the Faster R‐CNN target detection network. The experimental results on the rare earth element detection data set show that the MobileNet classification network is not suitable for optimizing the Faster R‐CNN network. After that, this paper proposes a classification network that combines VGG16 and MobileNet, and uses the fusion network to optimize the Faster R‐CNN target detection network. The experimental results on the rare earth element detection data set show that the Faster R‐CNN target detection network optimized by the fusion classification network has the advantages of using VGG16 and MobileNet’s Faster R‐CNN target detection network to detect rare earth elements. The innovation of this article is that the results on 5 time series data sets show that CDA‐WR has better predictive performance than other ELM variant models. The effect of determining trace cerium elements in rocks and minerals is increased by more than 50%, based on deep learning. The algorithm studies the methods of target detection and recognition and integrates it into the intelligent robot used in this subject, giving the robot the ability to accurately detect the target object in real time.
Open Innovation Mode of Green Innovation System for Manufacturing Industry
Authors: Bo Shao , Kexin Bi
Published: June 2021

The open mode of the manufacturing innovation system under conventional conditions makes it difficult to realize the open operation of the green innovation system, which also lacks operational capability and has low analysis coverage. Therefore, an open model of the green innovation system in the manufacturing industry is put forward. The opening and functional elements of the model are determined. The mechanism of the environmental aspects is clarified. The adaptability of different levels of the innovation process is discussed, and its evolution theory is derived. Finally, the best open innovation model’s selection rules are chosen to realize the analysis of the open innovation model’s mechanism. Its established operational index and model mechanism are discovered for the manufacturing industry. The experimental data show that our proposed model of the green innovation system is more efficient than the conventional model as its operational ability is increased by 33.42%, and the coverage rate is enhanced by 54.32%.
Research on Vibration Law of Railway Tunnel Substructure under Different Axle Loads and Health Conditions
Authors: Ma Weibin , Chai Jinfei , Zhu Zifeng , Han Zili , Ma Chaofeng , Li Yuanjun , Zhu Zhenyu , Liu Ziyuan , Niu Yabin , Ma Zhanguo , Gu Mu , Zhang Guoqiang , Li Cheng , Zhang Sen
Published: June 2021

In this paper, 25‐ton and 27‐ton axle heavy trucks are used to carry out moving loading and dynamic real vehicle test on the cracked section, the intact section, and the repaired section of a railway tunnel foundation to test the dynamic performance of the tunnel basement structure with the change of axle loads and health conditions. By analyzing the influence law of dynamic response and fatigue life of heavy haul train under different basement conditions (intact, damaged, and repaired), the adaptability of railway tunnel equipment to freight trucks axle load is clarified. The results show that (1) the intact section of the tunnel can meet the normal operation of 25‐ton and 27‐ton axle load freight trains in good condition. (2) The normal operation of 25‐ton and 27‐ton axle load freight trucks is seriously affected by the cracked section of the tunnel. When the cracks in the tunnel basement are gradually hollowed out by groundwater, serious traffic accidents such as vehicle shaking and derailment are likely to occur. (3) The repaired section of the tunnel can meet the normal operation of 25‐ton and 27‐ton axle load freight trains after adopting the integrated comprehensive treatment of “Anchor‐Injection‐Drainage”. The research results will have reference significance for the condition assessment and disease treatment of the basement structure of the heavy haul railway tunnel.
Gastric Adenocarcinoma in the Setting of IPEX Syndrome
Authors: Steffin David , Bhar Saleh , Fishman Douglas S. , Rider Nicholas L. , Naik-Mathuria Bindi , Martinez Caridad , Venkatramani Rajkumar
Published: June 2021

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare X-linked disorder caused by a loss of function mutation in the FOXP3 gene. It manifests early in infancy with clinical symptoms including autoimmune enteropathy, type 1 diabetes mellitus, and eczema. While aberrant FOXP3 expression has been associated with several types of cancer, little is known regarding the risk of cancer in patients with IPEX harboring the characteristic FOXP3 mutation. Here, we present a unique case of a primary signet ring gastric adenocarcinoma in a pediatric patient with IPEX syndrome.
Effects of Full Inhalation of Sevoflurane and Total Intravenous Anesthesia on Hemodynamics, Serum Myocardial Enzymes, and Myocardial Markers in Elderly Patients Undergoing Hysterectomy
Authors: Lan Xing , Yang Dong , Xie Shengnan , Zhao Zhenghua
Published: June 2021

Objective. To compare the effects of sevoflurane inhalation and intravenous anesthesia on hemodynamics, serum myocardial enzymes, and myocardial markers in elderly patients undergoing hysterectomy. Methods. Group A and group B were established randomly regarding a total of 126 elderly patients who underwent an elective hysterectomy. Patients in group A were given full anesthesia with sevoflurane, and patients in group B were given anesthesia with intravenous anesthesia. The operation time, anesthesia time, and recovery time in Postanesthesia Care Unit (PACU) were compared; plasma cortisol concentration, hemodynamics, serum myocardial enzymes, and myocardial markers were detected and compared between the two groups of patients before anesthesia (T0), after anesthesia (T1), and after surgery (T2). Results. Group A observed a longer extubation time and recovery time in PACU than group B (P < 0.05). Results show a lower systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and plasma cortisol concentration of T1 by comparison with those of T0 (P < 0.05), but no significant difference remains in terms of intergroup SBP, DBP, and HR (P > 0.05), and there was no interaction effect of groups and time (P > 0.05). The two groups showed no great disparity in the levels of lactate dehydrogenase (LDH), aspartate transaminase (AST), creatine kinase (CK), and CK‐MB as a subtype of CK before surgery between the two groups of patients (P > 0.05). After surgery, LDH, AST, CK, and CK‐MB levels in both groups were witnessed a surge, in which group A obtained higher levels of LDH, AST, CK, and CK‐MB (all P < 0.05). Conclusion. Total intravenous anesthesia will not increase the hemodynamic fluctuation of elderly patients undergoing hysterectomy and can reduce the damage to the myocardium of patients with surgical trauma, which can protect the myocardium of elderly patients to a certain extent, so it can be adopted as the optimal anesthesia protocol for surgery.
Xanthoma of Tendoachilles: Management and Follow-Up
Authors: Sahu Nabin Kumar , Nanda Saurav Narayan , Tripathy Milan , Samant Saswat , Tripathy Sumanyu Kumar , Gachhayat Ashok Kumar
Published: June 2021

Xanthoma is a rare pseudotumor of connective tissue, consisting of histiocytes with lipid deposits. Usually, it manifests as encapsulated lobular yellowish mass, often associated with familial hypercholesterolemia (FH). We present a case of xanthoma of tendoachilles just proximal to its insertion site, secondary to FH. The patient was a 28-year-old female presenting with a 2-year history of difficulty ambulating and complaints of swelling over the posterior aspect of her left lower leg just proximal to her heel. She had a deranged lipid profile level and was started on a lipid lowering agent for 3 weeks followed by total excision of the lesion with flexor hallucis longus tendon graft augmentation. The patient was able to bear full weight at 6 weeks and could stand on her toes by 4 months. No recurrences were noted at 1 year follow-up.
Association of Anxiety and Depressive Symptoms with Memory Function following Traumatic Brain Injury
Authors: Li Gaoyi , Han Xi , Gao Liang , Tong Wusong , Xue Qiang , Gong Shun , Song Yu , Chen Songyu , Dong Yan
Published: June 2021

Introduction: Memory impairment and mood disorders are among the most troubling sequelae following traumatic brain injury (TBI). The relationships between comorbid psychiatric disorders and memory function have not been well illustrated. The aim of the study was to explore the relationships of comorbid anxiety and depressive symptoms with memory function following TBI. Methods: A total of 46 TBI participants across all levels of injury and 23 healthy controls were enrolled in this case-control study. Wechsler Memory Scale-Chinese Revision (WMS-CR) picture, recognition, associative learning, comprehension memory, and digit span were administered to evaluate several categories of memory capacity. The Hospital Anxiety and Depression Scale (HADS) was employed to evaluate the anxiety and depressive symptoms. Stepwise multiple linear regressions were conducted. Results: Compared to healthy controls, the participants with TBI reported more anxiety and depressive symptoms. In the meanwhile, they performed more poorly on memory tests, showing 1.84 SDs, 1.07 SDs, and 0.68 SDs below healthy participants on visuospatial memory, working memory, and verbal memory, respectively. A variety of variables, including HADS depression, HADS anxiety, age, GCS, and education were associated with posttraumatic memory function in the bivariate models. The stepwise multiple linear regressions demonstrated a negative association between HADS depression and posttraumatic memory function, especially performance on visuospatial and verbal memory and a positive association between education and posttraumatic memory function. Conclusion: More depressive symptoms rather than anxiety symptoms and less years of education are significant predictors for posttraumatic memory dysfunction.
Intestinal Epithelial Cell-Derived CD83 Contributes to Regulatory T-Cell Generation and Inhibition of Food Allergy
Authors: Yu Yong , Jin Qiao-Ruo , Mi Yang , Liu Jiang-Qi , Liu Zhi-Qiang , Wang Shuai , Liu Zhi-Gang , Yang Ping-Chang , Zheng Peng-Yuan
Published: June 2021

The mechanism of generation of antigen-specific regulatory T cells (Treg) is not fully understood yet. This study aimed to investigate the role of intestinal epithelial cell (IEC)-derived CD83 in the Treg generation in the intestine. In this study, the role of CD83 in the generation of Tregs was assessed in a cell-culture model and a food allergy (FA) mouse model. We found that mouse IECs expressed CD83; its levels were markedly lower in sensitized mice. Mice with CD83-deficient IECs failed to induce Tregs in the intestine. CD83 promoted the transforming growth factor-β-inducible early gene 1 (TIEG1) expression in CD4+ T cells. Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex mediated the effects of CD83 on the expression of TIEG1. Activation of the CD83/TLR4/MD-2/TIEG1 promoted the Treg generation. Concomitant administration of CD83 and specific antigens, but not either one alone, efficiently inhibited experimental FA via inducing the Treg generation in the intestine. In Conclusion, IEC expresses CD83 that is low in sensitized mice. Concomitant administration of CD83 and specific antigens efficiently inhibits FA in a murine model via inducing Tregs in the intestine. The data suggest that CD83 has translation potential in the treatment of FA.
Incidental Finding of MEGDEL Syndrome Based on Neuroimaging: Case Report
Authors: Alshammari Salma A. , Alghamdi Fouad A. , Alhazmi Rami , Aldossary Shaikhah
Published: June 2021

MEGDEL 3-methylglutaconic (MG) aciduria, deafness, encephalopathy, Leigh-like syndrome is an autosomal recessive disorder associated with infantile hypoglycemia, progressive psychomotor developmental delay, cerebellar atrophy with lesions in the basal ganglia, spasticity, dystonia, deafness, and transient liver problems, which typically occur in the first year of life. Other clinical presentations include failure to thrive, epilepsy, and optic nerve atrophy. The serine active site-containing 1 (SERAC1) mutation is localized at the mitochondria-associated membranes, which are responsible for encoding a phosphatidylglycerol remodeler essential for both mitochondrial function and intracellular cholesterol trafficking and is thus responsible for the disease. Diagnosis is confirmed by the elevation of and concentrations of 3-MG acid and 3-methylglutaric acid in the urine or by identification of bi-allelic SERAC1 pathogenic variants on molecular genetic testing. Different pathological variants of SERAC1 have been identified in MEGDEL syndrome to date. Here, we report a case of a child with MEGDEL syndrome due to SERAC1 mutation. The child presented with accidental finding by CT showing hypodensity on bilateral symmetric anterior putamen and caudate abnormal. Neurological examination was unremarkable. This report presents a new neuroimaging finding by CT of MEGDEL syndrome.
Maternal Depressive Risk in Prenatal versus Postnatal Surgical Closure of Myelomeningocele: Associations with Parenting Stress and Child Outcomes
Authors: Schreiber Jane E. , Cole Joanna C.M. , Houtrow Amy J. , Kallan Michael J. , Thom Elizabeth A. , Howell Lori J. , Adzick N. Scott
Published: June 2021

Introduction: Depressive risk is higher for mothers of infants with chronic medical conditions. The present study examined maternal depressive risk and associations with parent and child outcomes among mothers of young children who were randomized to either prenatal or postnatal surgical closure for myelomeningocele. Methods: Using the Management of Myelomeningocele Study database, maternal depressive risk was examined at 3 time points as follows: prior to birth, 12 months, and 30 months post birth. Separate multivariate analyses examined associations among change in depressive risk (between baseline and 30 months), parenting stress, and child outcomes at 30 months. Results: Mean scores were in the minimal depressive risk range at all the time points. Post birth depressive risk did not differ by prenatal versus postnatal surgery. Mean change scores reflected a decrease in depressive risk during the first 30 months. Only 1.1–4.5% of mothers reported depressive risk in the moderate to severe range across time points. Increased depressive risk during the first 30 months was associated with increased parenting stress scores and slightly lower child cognitive scores at 30 months. Conclusion: Most mothers reported minimal depressive risk that decreased over time, regardless of whether their infant underwent prenatal or postnatal surgery. Only a small percentage of mothers endorsed moderate to severe depressive risk, but an increase in depressive risk over time was associated with higher parental stress and slightly lower child cognitive development.
Evaluation of Renal Oxygenation and Hemodynamics in Patients with Chronic Kidney Disease by Blood Oxygenation Level-dependent Magnetic Resonance Imaging and Intrarenal Doppler Ultrasonography
Authors: Yang Jing , Yang Shuohui , Xu Yizeng , Lu Fang , You Lan , He Zheng , Zhan Songhua , Ye Chaoyang , Liu Mengxiao , Fu Caixia , Wang Chen
Published: June 2021

Introduction: The basic pathophysiologic derangement of chronic kidney disease (CKD) begins with the loss of nephrons, leading to renal hemodynamic changes, eventually causing a reduced nephron count and renal hypoxia. The purpose of this study was to observe the renal oxygenation and renal hemodynamics of patients with CKD using blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) and intrarenal Doppler ultrasonography (IDU). Methods: The study enrolled 39 patients with stage 1–4 CKD and 19 healthy volunteers (HVs). Based on their estimated glomerular filtration rate (eGFR), CKD patients were divided into 2 subgroups: a mild renal impairment (MI) group and a moderate to severe renal impairment (MSI) group. We monitored the participants’ mean cortical T2* (COT2*) and mean medullary T2* (MET2*) values on BOLD-MRI, and measured the peak systolic velocities (PSVs), end-diastolic velocities (EDVs), renal resistive index (RI), and kidney length by IDU. We also recorded clinical indicators such as age, sex, body mass index (BMI), 24-h urinary protein (24-h Upr), serum creatinine (sCr), blood urea nitrogen (BUN), and eGFR. BOLD-MRI, IDU measurements, and the clinical indicators were compared in CKD patients and HVs by the analysis of variance and Kruskal-Wallis H test. Spearman’s correlation was used to assess the relationship between data from BOLD-MRI and IDU and clinical indicators. Results: The COT2* values were significantly higher than the MET2* values in the HV, MI, and MSI groups. COT2*, MET2*, EDV, PSV, and kidney length gradually decreased in the HV, MI, and MSI groups (all p < 0.05), whereas RI and 24-h Upr gradually increased (both p < 0.05). Spearman correlation analysis showed that COT2* and MET2* were significantly positively correlated with eGFR, PSV, EDV, and kidney length but were significantly negatively correlated with sCr, BUN, and 24-h Upr (all p < 0.05). There was no correlation observed between the COT2* and MET2* and the RI and BMI values. Conclusions: Renal oxygenation and blood flow velocities were found declined as the CKD stage progressed. The BOLD-MRI and IDU techniques may have clinical value by measuring intrarenal oxygenation and renal blood perfusion to judge the severity of renal damage in patients with CKD.
Automated Detection and Diameter Estimation for Mouse Mesenteric Artery Using Semantic Segmentation
Authors: Higaki Akinori , Mahmoud Ahmad U.M. , Paradis Pierre , Schiffrin Ernesto L.
Published: June 2021

Background: Pressurized myography is useful for the assessment of small artery structures and function. However, this procedure requires technical expertise for sample preparation and effort to choose an appropriate sized artery. In this study, we developed an automatic artery/vein differentiation and a size measurement system utilizing machine learning algorithms. Methods and Results: We used 654 independent mouse mesenteric artery images for model training. The model yielded an Intersection-over-Union of 0.744 ± 0.031 and a Dice coefficient of 0.881 ± 0.016. The vessel size and lumen size calculated from the predicted vessel contours demonstrated a strong linear correlation with manually determined vessel sizes (R = 0.722 ± 0.048, p < 0.001 for vessel size and R = 0.908 ± 0.027, p < 0.001 for lumen size). Last, we assessed the relation between the vessel size before and after dissection using a pressurized myography system. We observed a strong positive correlation between the wall/lumen ratio before dissection and the lumen expansion ratio (R = 0.832, p < 0.01). Using multivariate binary logistic regression, 2 models estimating whether the vessel met the size criteria (lumen size of 160–240 μm) were generated with an area under the receiver operating characteristic curve of 0.761 for the upper limit and 0.747 for the lower limit. Conclusion: The U-Net-based image analysis method could streamline the experimental approach.
Role of Radiotherapy in Recurrent Intra-Abdominal Yolk Sac Tumor
Authors: Utama Marhendra Satria , Kurniadi Andi , Prahastiwi A.A. Citra Yunda , Adibrata Antony A.
Published: June 2021

Yolk sac tumor (YST) is a rare malignant germ cell tumor with no appropriate treatment strategy to date. However, patients are treated on a case-to-case basis as per various case reports that have been published. Here, we present a case of 27-year-old female patient who presented to us with chief complaints of severe abdominal pain associated with leucorrhea. She previously had a similar pain episode, which was then evaluated by a multidisciplinary team. She was diagnosed with YST. After that, she underwent 6 cycles of chemotherapy, but there was no improvement. Then the medical oncologist referred her to performed radiotherapy. Then, the radiation oncologist decided to give her curative radiotherapy of 3D-CRT. After completing her sessions, she felt better and clinically improving. After that, she was discharged and scheduled a follow-up visit for first evaluation. At her follow-up visit, she was feeling well, and we decided to have an abdominal MRI.
O papel da mediação da informação na biblioteca escolar
Authors: Correia Erica Mariza , Belchior Cleide Aparecida Freires , Fialho Janaina Ferreira
Published: June 2021

Esta pesquisa abordou o papel do bibliotecário no que tange a mediação da informação no ambiente da biblioteca escolar por meio de uma revisão narrativa de literatura. Parte da compreensão de que para que esse processo se desenvolva é necessário o apoio do profissional mediador da informação, assim como de espaços disponíveis para a ampliação e disseminação de saberes por meio da apropriação da informação. Para tanto, tem como objetivo geral avaliar o papel da mediação da informação na biblioteca escolar e abordar alguns temas como o papel da informação na sociedade da informação e do conhecimento; mediação e apropriação da informação no campo da Ciência da Informação e bibliotecas escolares como dispositivos informacionais. A metodologia utilizada foi a revisão narrativa de literatura, caracterizando-se como pesquisa bibliográfica, de natureza qualitativa. Observou-se que o papel da mediação da informação produz maior eficácia com o auxílio de um profissional da informação, além disso, o acesso à informação e ampliação do conhecimento nesses espaços de saberes proporcionam maiores habilidades e competências nos sujeitos, utilizando-se da teoria da competência informacional. Sendo assim, a mediação da informação ocorre com a interferência desse profissional, seja nas trocas de ideias, na interação social, no compartilhamento de informações, com a participação ativa de sujeitos protagonistas, ou no processo de busca por aprendizados contínuos. O profissional da informação poderá fazer a diferença ao interferir ampliando o acesso, facilitando a apropriação e situando a biblioteca escolar como espaço de construção de significados e compartilhamento de saberes que geram conhecimentos produtivos.
A biblioteca escolar como agente potencializador do processo ensino-aprendizagem
Authors: Lipinski Barbara , Cristovam Poliana Fragatti
Published: June 2021

A biblioteca escolar é de suma importância no contexto educacional, embora nem sempre, ao longo de sua história, tenha sido reconhecida como tal. Considerando que ela desempenha, hoje, um papel que vai muito além de um espaço para promoção de leitura, este artigo objetiva compreender a importância da biblioteca escolar como um instrumento no processo de ensino-aprendizagem, a fim de identificar a relevância do apoio da coordenação pedagógica e dos professores para esse processo, bem como empregar atividades facilitadoras que possam colaborar para tornar essa teoria uma possível realidade. Para tanto, realizou-se uma pesquisa de natureza qualititativa, revisão bibliográfica e relato de experiência em uma instituição particular do ensino básico, pertencente a uma rede educacional, localizada no norte do estado do Paraná. Os resultados apontaram que o trabalho interdisciplinar é imprescindível para uma melhor prestação de serviços para a comunidade escolar, bem como a participação ativa e cooperativa do bibliotecário, da coordenação e do corpo docente faz deles os principais agentes potencializadores do processo de ensino-aprendizagem, quebrando paradigmas e criando um conceito diferente de biblioteca escolar, tanto para o corpo discente quanto para o docente.
Bibliotecas universitárias: uso de estratégias comunicacionais de combate à desinformação no contexto da pandemia Covid-19
Authors: Vidarte Vanessa Cristiane Dornelles , Velasco Shana Catiusca Dornelles Vidarte
Published: June 2021

O advento da “sociedade informacional” (CASTELLS, 1999) surge dedicando espaço à informação. Embora tão relevante para essa sociedade, o extenso volume de informações veiculadas por meio das mídias sociais favorece a disseminação de informações falsas. Recentemente, a Organização Mundial da Saúde declarou que a pandemia Covid-19* gerou uma infodemia, fenômeno que agrava ainda mais a atual crise de saúde pública. Pensando nisso, este artigo objetiva analisar como as bibliotecas universitárias podem contribuir para controlar a desinformação, através do uso de estratégias comunicacionais. Para tanto, como procedimento metodológico realizou-se uma revisão bibliográfica relacionando os tópicos:  sociedade informacional e seus desafios como “pós-verdade” (DELFINO et al., 2019) e infodemia, desinformação e formação da opinião pública, bem como um mapeamento nos sites e mídias sociais de algumas bibliotecas universitárias, no período de paralisação das atividades presenciais. Como resultado, verificamos que a pós-verdade se tornou uma consequência de uma sociedade, dita ‘informacional’, mas que não sabe usar a informação apropriadamente. Além disso, compreendeu-se que a desinformação é uma estratégia de manipulação da opinião pública, visto que interfere na capacidade dos indivíduos de interpretar e avaliar a informação. Depreendeu-se que as bibliotecas estudadas têm utilizado eficazmente estratégias comunicacionais como a publicação de conteúdos informativos nas mídias sociais, que auxiliam os usuários na avaliação crítica das informações recebidas. Conclui-se que as bibliotecas universitárias, como mediadoras dos processos de interação e relacionamento do usuário com a informação, desempenham um importante papel no combate à desinformação.
Sobre o conceito de paisagem geográfica
Authors: Baldin Rafael
Published: June 2021

A noção de paisagem não é recente na História: ela é tão antiga quanto a própria sociedade. Vinculada até então como conceito estético, foi somente no século XIX que se concebeu Paisagem como conhecimento científico dentro da sistematização do saber geográfico, confundindo-se com o próprio surgimento da disciplina. Na década de 1970 vemos o despontar da Geografia Cultural e a noção de paisagem se acopla a de representação. No olhar de quem observa há valores que são apropriados, como palimpsesto, na vivência. A paisagem então é um processo sócio-histórico que se constrói e reconstrói, resultado de interações complexas. Paisagem também reflete relações de poder e dominação. Atualmente o termo goza de renovação teórico-metodológica e é um conceito-chave do arcabouço do saber geográfico.
ANXA7 Regulates Platelet Lipid Metabolism and Ca
2+
Release in Arterial Thrombosis
Authors: Manke Mailin-Christin , Geue Sascha , Coman Cristina , Peng Bing , Kollotzek Ferdinand , Münzer Patrick , Walker Britta , Huber Stephan M. , Rath Dominik , Sickmann Albert , Stegner David , Duerschmied Daniel , Lang Florian , Nieswandt Bernhard , Gawaz Meinrad , Ahrends Robert , Borst Oliver
Published: June 2021

Rationale:

Platelet activation after contact to subendothelial collagen leads to acute arterial thrombosis. ANXA7 (Annexin A7) is a phospholipid-binding protein participating in the regulation of intracellular Ca
2+
and exocytosis.

Objective:

The present study aimed to determine the role of ANXA7 in platelet Ca
2+
signaling and lipid metabolism during platelet activation in arterial thrombosis using the ANXA7 inhibitor 6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine (ABO) and gene-targeted mice lacking
Anxa7
(
Anxa7
−/−
).

Methods and Results:

ANXA7 is strongly expressed in platelets. Functionally, luminescence aggregometry revealed significantly abrogated aggregation and secretion of ABO-treated or
Anxa7
−/−
platelets when compared with untreated or
Anxa7
+/+
platelets after activation with collagen or the GPVI (glycoprotein VI)-specific agonist collagen-related peptide. Furthermore, while both thrombus formation on collagen-coated surfaces under high arterial shear rates in ABO-treated or
Anxa7
-deficient whole blood, and thrombotic vascular occlusion after FeCl
3
-induced injury in vivo in
Anxa7
−/−
bone marrow chimeric mice were significantly diminished, no prolongation of bleeding time was observed in ABO-treated or
Anxa7
−/−
mice. Fura-2-AM spectrofluorimetry unraveled a blunted [Ca
2+
]
i
increase in ABO-treated or
Anxa7
−/−
platelets after GPVI stimulation. Due to an abolished phospholipase Cγ2 phosphorylation,
Anxa7
−/−
platelets displayed abrogated intracellular Ca
2+
mobilization following collagen-related peptide-dependent platelet activation. Quantitative lipidomics analysis further revealed that ANXA7 critically affects platelet oxylipin metabolism following GPVI-dependent platelet activation.
Anxa7
−/−
platelets showed a significantly reduced generation of several bioactive metabolites, particularly thromboxane A
2
and 12(S)-hydroxy-eicosatetraenoic acid. Finally, defective phospholipase Cγ2 phosphorylation and blunted [Ca
2+
]
i
increase in
Anxa7
−/−
platelets could be rescued by exogenous addition of 12(S)-hydroxy-eicosatetraenoic acid, indicating that ANXA7 is a critical regulator of the platelet 12-lipoxygenase in GPVI-dependent platelet Ca
2+
signaling during arterial thrombosis.

Conclusions:

The present study unravels ANXA7 as a regulator of oxylipin metabolism and Ca
2+
-dependent platelet activation downstream of GPVI. ANXA7 plays an important role in platelet signaling during arterial thrombosis and thus may reflect a promising target for novel antiplatelet strategies.