bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis on the Current Situation and Teaching Strategies of Psychological Health Education for College Students
Authors: Shi Xin
Published: April 2023

In recent years, there have been frequent and increasing cases of college students harming themselves and others due to psychological problems and other reasons, which has sparked the increasing attention of the Party Central Committee and education departments at all levels to the mental health education of college students. Education experts have also included mental health education in the work of moral education in colleges and universities, and their expectations for mental health education in colleges and universities are constantly increasing. Currently, students' mental health issues have attracted great attention from all sectors of society, and universities have begun to reflect on the problems existing in the process of mental health education. Based on an in-depth analysis of the current situation of mental health education for college students, this article proposes effective solutions to promote the healthy development of mental health education in colleges and universities.
Research on the Ways to Improve the Service Quality of Tourism Enterprises in the Background of Digital Transformation
Authors: Ruhang Wang
Published: April 2023

In the context of the digital economy, with the continuous integration of digital resources and network organizations, it is an inevitable trend for enterprises to implement digital transformation of the network. The digital transformation of enterprise networks should be realized under the condition that each node enterprise is connected through resource sharing and complementary advantages. However, the connection of node enterprises under the background and characteristics of digital cooperation can generate various transformation methods, and it is necessary to explore the most effective transformation path through empirical research. In the field of value theory, the article attempts to apply "people-oriented" as an idea and a path to specific industries such as tourism. Aiming at the problems existing in tourism services, based on the concept of "tourism practitioners oriented", this paper proposes corresponding countermeasures to improve the quality of tourism services.
Research on Innovation of College Korean Teaching Methods from the Perspective of Intercultural Communication
Authors: Chunying Wang
Published: April 2023

Basic Korean language courses are both a process of language learning and a process of experiencing Korean culture for beginners of Korean language from a zero-starting point in universities. The introduction of culture into Korean language teaching is crucial for stimulating students' interest in learning, innovating learning methods, improving learning effectiveness, and cultivating students' cross-cultural communication skills. This article explores a new approach to the reform of Korean language teaching based on the introduction of culture into junior Korean language teaching in universities. The Korean song introduction method, task driven method, and speech lab Korean speech chat method have good innovative applications in Korean language teaching, which plays an important role in promoting the realization of Korean language teaching objectives in vocational colleges and achieving the optimization of Korean language teaching effects.
Practice of Intelligent Platform for Mental Health Education in Colleges Based on Automatic Identification and Retrieval Algorithm of Philosophical Texts
Authors: Shi Xin
Published: April 2023

Image retrieval based on semantic correlation analysis of philosophical texts and extended retrieval of similar images based on SIFT features. According to the analysis of natural language processing technology, the keywords and their semantic associations in the user's text requirements are obtained. The dynamic transmission and transformation of text value under the influence of multi-system factors outside the text is the premise and basic feature of system reconstruction. The author tries to use psychological sitcoms to explore a participatory, experiential, and situational mental health education method, and guide students to discover, analyze and solve psychological problems by themselves, so as to know themselves, understand others, gain self-growth, and promote health. For the development of body and mind, use genetic algorithm to design paragraph retrieval algorithm, use the search algorithm of philosophical text to query the feature extraction of mental health of college students, and then use the index algorithm to carry out text modeling and philosophical development.
Research on Synchronous Cooperation between Computer Information Technology and Network Security Application
Authors: Meng Chen
Published: April 2023

The development and application of computer information technology is based on the major premise of the network security environment. To achieve the sustainable development of computer information technology, it is necessary to establish a safe and stable network environment. The advancement and development of network security technology is driven by computers. Information technology is developed based on the problems presented in the development process. From this point of view, there is a complementary relationship between the development of computer information technology and network security. This article is a research on the synchronization and coordination between the development of computer information technology and network security, and aims to promote the development of computer information technology through the establishment of a network security environment.
Aplicação do PROMSORT para priorização de demandas do orçamento participativo: o caso da prefeitura de Campina Grande-PB
Authors: Cardoso Mayne Ramos Almeida
Published: April 2023

Atualmente, a gestão pública municipal possui problemas de tomada de decisão no direcionamento dos recursos públicos para as obras mais demandadas pela sociedade. No município de Campina Grande - PB, para que a gestão pública tome conhecimento das demandas da população, utiliza-se o instrumento mais atual de participação popular, o Orçamento Participativo (OP), para que através dele, a tomada de decisão seja conforme as demandas da população. Como essas decisões não afetam apenas os gestores públicos, mas também a sociedade civil, as decisões precisam ser realmente direcionadas para o que mais precisa a população. E no caso do município de Campina Grande, as demandas eleitas pelo Orçamento Participativo são direcionadas para os Secretários Municipais que atuam nesse processo como o único decisor, e como a execução de uma obra pública exige a análise de múltiplos critérios, o trabalho trata de um estudo de caso, no qual, a aplicação de um Modelo de Apoio a Decisão Multicritério oferece suporte à decisão para o gestor público da Secretaria de Saúde do Município de Campina Grande, de modo que classifique ordenadamente as demandas eleitas pelo Orçamento Participativo em classes de prioridades. Esse suporte é baseado no método criado por Araz & Ozkarahan no ano de 2005, chamado PROMSORT. Este método classificou as demandas do Orçamento Participativo no âmbito da Saúde em três classes de prioridades: alta; média; e baixa. O resultado que se obteve com a presente pesquisa, foi que há demandas inseridas nas classes de alta, média e baixa prioridade, e que algumas variam de classe conforme a concepção do decisor em ser otimista ou pessimista. Este trabalho demonstra a relevância da aplicação de um modelo multicritério para o processo decisório de execução das demandas do Orçamento Participativo em Campina Grande, estruturando os critérios necessários para uma decisão coesa, diferenciando completamente da atual metodologia que vem sendo utilizada há anos no município. Portanto, pode-se concluir que o método PROMSORT se fez adequado para a problemática em questão, pois como classifica as demandas em classes ordenadas de prioridades, dando auxílio ao gestor público a decidir por demandas com maior grau de prioridade e que mais satisfarão as necessidades da população.
Análise AS-IS do processo produtivo de uma pequena empresa: aplicações do mapa de fluxo de valor e indicadores de desempenho
Authors: Stocco Paula Vasconcelos , Kurumoto Juliana Sayuri
Published: April 2023

O objetivo desta pesquisa é apresentar uma análise AS-IS (situação atual) do processo produtivo de uma pequena empresa metalúrgica que produz autoclaves, uma vez que a empresa busca melhorar a qualidade dos seus processos, diminuir a quantidade de retrabalhos externos e internos, além de minimizar os atrasos de entrega. O objetivo desta análise é identificar os principais pontos críticos do processo. Para isso foi utilizado o mapa de fluxo de valor e os indicadores de desempenho como ferramentas. Os conceitos de mapa de fluxo de valor e indicadores de desempenho foram esclarecidos em uma inicial revisão bibliográfica, seguida pela construção do mapa de fluxo de valor e da apresentação dos indicadores de desempenho relevantes neste contexto. Como principais resultados da análise do processo produtivo explicitou-se a necessidade de melhoria do lead time, da redução dos estoques intermediários e do tempo de troca de ferramentas. Notou-se também a efetividade da utilização das duas ferramentas, que mostraram, a princípio, ser complementares entre si.
Ovarian Carcinoma Presenting as Meigs’ Section Syndrome- A Rare Case Report
Authors: Ankita Francis , Sahana K , Ravichandar Sabarinath , Jishna G
Published: April 2023

Presence of fluid and air within pleural space is known as hydropneumothorax. A large proportion of patients present with shortness of breath, dry cough and pricking type of pleuritic chest pain as a result of pleural involvement. However, fever and constitutional symptoms like loss of appetite and loss of weight is most likely associated with tuberculosis. Meigs’ syndrome is a triad of ascites, hydrothorax and benign ovarian tumours (ovarian fibromas and fibrothecomas). Pseudo-Meigs’ syndrome shows accumulation of ascites, pleural effusion and associated with a pelvic or abdominal tumours. Here, is a case report of a 62-year-old postmenopausal female, who presented with right pleuritic chest pain and breathlessness, since one week. Chest radiograph showed right-sided hydropneumothorax which required an intercostal drainage tube insertion. Upon further evaluation, the primary unknown cancer was found to be of ovarian origin.
Serum miRNA-30a-5p in Steroid Sensitive Idiopathic Nephrotic Syndrome in Indian Children: A Case-control Study
Authors: Sreekumar Abhishek , Safwan Gundyadka Moideen , Shetty Shilpa J , Kumari Suchetha , Shenoy Rathika D , Shenoy Vijaya
Published: April 2023

Introduction: Childhood Nephrotic Syndrome (NS) is a podocytopathy. Micro Ribonucleic Acid (miRNA), composed of 21-25 non coding nucleotides, regulates gene expression by inhibiting protein transcription by binding to complementary messenger RNA. The microRNA-30a is expressed in the human glomerular podocytes and collecting ducts. This microRNA protects the podocytes by targeting the Calcineurin-nuclear Factor of Activated T cells (NFATc) pathways. Serum microRNA30a-5p is a validated biomarker which is upregulated in NS. Aim: To determine the serum miRNA-30a-5p in steroid sensitive idiopathic NS in Indian children. Materials and Methods: This case-control study was conducted at the Department of Paediatrics, KS Hegde Medical Academy, Mangalore, Karnataka, India, from from January 2018 to June 2019. Thirty children with NS and age and gender matched controls were recruited. Relative expression of microRNA-30a5p was analysed by Real-Time quantitative Polymerase Chain Reaction (RT-qPCR). Estimations were done both in cases and controls at enrollment and also at four weeks when in remission in cases. The fold change was calculated as a power of cycle threshold. Statistical tests Kolmogorov-Smirnov test was used to establish the normality using Statistical Package for Social Sciences (SPSS) version 22.0. Results: There was upregulation of microRNA-30a-5p expression among children with NS with a significant fold change (~184) at enrollment. The levels declined, but remained above baseline (~6) after four weeks of treatment when compared to controls. The mean differences in delta threshold cycle and threshold cycle between the three groups were significant (p<0.001). There was no correlation with the biochemical parameters. Conclusion: The present study concludes that serum microRNA-30a-5p expression is upregulated in children with steroid sensitive NS in Indian children.
Role of Dermal Ridge Patterns in Prediction of Periodontal DiseaseA Cross-sectional Study
Authors: Kumar Tamil Selvan , Beulah Maria , James Johnson Raja , Raja SA Jacob , Raj JP Mohan , Rajkumar Gokulvathi , Fairlin P , Ahamed Faizal
Published: April 2023

Introduction: Periodontitis is a chronic inflammatory disease which affects the supporting tissues of the teeth and was initially thought to be environmental in origin. The difference in the disease prevalence among the population could not be attributed to environment alone. Limited studies have been done on diagnosing the future occurrence of periodontal diseases by recording the finger print patterns of the patients. Aim: To evaluate the relationship between finger prints patterns existing among patients with plaque induced gingivitis, chronic localised and generalised periodontitis. Materials and Methods: This was a cross-sectional observational study, carried out over a period of 6 months from January 2022 to July 2022) at Rajas Dental College and Hospital, Kavalkinaru. Subjects were equally divided into three groups including 100 patients under each group- Group-I as plaque induced gingivitis, group II as localised chronic periodontitis and group III as generalised chronic periodontitis based on 1999 classification system. The finger print patterns observed were loops, whorls and arches. The fingerprint patterns were compared within the group and also between the three groups. Boneferroni test and analysis of variance test were used for statistical analysis. Results: Total of 300 patients were included in this study, out of which 175 were males and 125 were females with the mean age 34.16±1.33 years. On comparison of the fingertip patterns within the groups, a significantly equal distribution of whorl and loop patterns with a value of 4.950±3.11 and 4.750±3.10 respectively were found among the Group-I subjects. A significantly increased prevalence of whorls with a value of 5.300±3.37 was found in Group-II subjects and significantly increased prevalence of loop pattern with a value of 5.800±2.72 was found among Group-III subjects. The arch pattern was more in Group-II and GroupIII when compared to Group-I with a value of 1.450±2.21 and 1.200±1.33, respectively. Conclusion: It was concluded that a strong association between fingerprint patterns and chronic periodontitis existed. The present study proved that dermatoglyphics can be used as a powerful tool for early prediction and better prevention of periodontitis.
Retrospective Analysis of Otorhinolaryngology Related Elective Surgeries Performed in a Tertiary Care Centre, North Kerala, India
Authors: Afsal E Muhammed , Suma R
Published: April 2023

Introduction: Due to a better understanding of the disease process, surgical workshops, conferences, and better patient awareness, the trend of Ear Nose Throat (ENT) related surgeries has changed significantly over the years. Aim: To analyse the profile of various ENT-related elective surgeries performed over three years in a tertiary care centre. Materials and Methods: This retrospective observational study was conducted in the Department of ENT, in a tertiary care centre, North Kerala, India. Patients of both sexes and of all age groups who underwent elective ENT surgeries in the Department from January 2017- December 2019 were included in the study. Data analysis was done from 1/12/2020 to 1/6/2021 period. Emergency surgeries were excluded from the study. Data was collected from hospital records and analysed using appropriate statistical methods. Results: A total of 2895 patients underwent various major and minor procedures in the period of January 2017 to December 2019 in the study institute. The majority of procedures were tympanomastoid surgeries (n=896, 30.94%), which were followed by sinonasal surgeries including advanced endoscopic surgeries (n=670, 23.14%), tonsilloadenoid surgeries (n=550, 18.98%) and excision of various solid and cystic lesions from head and neck region (n=310, 10.70%). The remaining number contributed by various other procedures like laryngeal surgeries (n=99, 3.4%) and other miscellaneous procedures (n=370, 12.78%) which include preauricular sinus excision, punch biopsies, tongue tie release, styloidectomy, excision of rhinosporidiosis from nose and nasopharynx, nasal bone fracture reduction and young’s operation. Conclusion: The most common elective procedures performed in the study period were tympanomastoid surgeries. In the present study, there was an increasing trend of all major and minor surgeries in the department in subsequent years.
Evaluation of Fine Needle Aspiration Cytology versus Culture for Laboratory Diagnosis of Subcutaneous Mycosis
Authors: Gouda Kalyani Prava , Panda Pritilata , Mohanty Indrani , Das Upasana
Published: April 2023

Introduction: Subcutaneous swellings are commonly seen in clinical practice having varied pathology from epidermal inclusion cyst to malignancy. Subcutaneous mycosis is a fungal infection of subcutaneous tissue and dermis which is more prevalent in workers of rural, tropical, and subtropical regions. The subcutaneous infection mostly occurs due to minor trauma which goes unnoticed. Fine Needle Aspiration Cytology (FNAC) followed by microbiological analysis is a cost-effective and simple procedure and can be considered as one of the main modalities for early diagnosis. Moreover, it gives an early presumptive identification of fungus, which helps the clinician in a timely therapeutic approach. Aim: To study the efficacy of FNAC in the diagnosis of subcutaneous mycosis in comparison with culture method. Materials and Methods: A cross-sectional study, including clinically diagnosed cases of subcutaneous mycosis was evaluated between the periods of March 2019 to February 2021 in a tertiary care hospital in Northern Odisha. FNAC samples from all the cases of subcutaneous mycosis were studied cytologically and microbiologically. Cases were analysed and further evaluated on the basis of their age, sex, detailed clinical history, and presentation. FNAC showed the presence of fungal elements in 20 cases. Microbiological evaluation of these samples was carried out. Results: Out of the total 50 cases of subcutaneous mycoses, male (16): female (4) ratio was 4:1 and the commonest age group affected was 20-60 years of age (75%). The most common site of involvement was the lower limb (60%) followed by upper limb (30%). Almost all the cases were from rural areas with a history of trauma present in 11 cases (55%). Out of 50 clinically diagnosed cases, cytological examination revealed fungal element in 20 (40%) cases. The most common cytological diagnosis was abscess with neutrophilic infiltration seen in 13 cases (65%) followed by granuloma in 7 cases (35%). All the 20 samples were further evaluated in conventional methods like KOH mount and culture. Fungal agents were isolated in 13 (65%) cases. Cladosporium spp. was the commonest isolate in 5 cases (25%). Conclusion: Subcutaneous mycosis is a rare disease. FNAC can be used as a rapid and cost-effective screening tool in the diagnosis of such cases as it is more sensitive. Though culture is the gold standard test, it is less specific.
COVID-19 Convalescent Plasma Collection: A Cross-Sectional Study From the Perspective of Transfusion Medicine
Authors: Rajan Archana , Narayanan Deepa
Published: April 2023

Introduction: Convalescent plasma from cured symptomatic COVID-19 patients was one of the many treatment options rolled out during the COVID-19 pandemic. The high levels of viral neutralizing antibodies in plasma of those who had contracted the disease, and clinical improvement in viral pneumonias like Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) treated with convalescent plasma was the consideration behind this. Aim: To study recruitment including demographic characteristics of plasma donors, and recording any adverse donor reactions. Materials and Methods: This prospective cross-sectional study was conducted at the Department of Transfusion Medicine, Govt. Medical College, Kozhikode, Kerala, India from July 2020 to March 2021. All plasma donors who met the inclusion criteria as per the Kerala Government order permitting compassionate use of convalescent plasma were included in the study. Plasma collection was done using the Hemonetics MCS+ (MultiComponent System) Apheresis system and semiquantitative in-vitro determination of human antibodies, immunoglobulin class IgG against S1 domain of spike protein of SARS-CoV-2 was performed using EUROIMMUN anti-SARS CoV -2 ELISA. Results: Among the124 convalescent plasma donors, more than 90% donors were males of the age group 18-40 years and with a prior history of blood donation (repeat donors). Ninety donors (73%) had symptomatic COVID-19, 34 (27%) were asymptomatic. COVID-19 antibody determination showed 82 (66%) positive cases, 32 (26%) negative cases and 10 (8%) cases with borderline values. COVID-19 antibody was positive in 65 (72.2%) of the donors who were symptomatic compared to 17 (50%) asymptomatic donors. Adverse reactions were noted in 40 cases (32.26%), of which the procedure was discontinued in two. Conclusion: Donors with prior donation history and in the age group 18-40 years are more likely to donate. This study also showed a significant antibody response in symptomatic COVID-19 donors versus the asymptomatic. Low rate of serious adverse reactions amounting to stopping the procedure confirms its safety.
Management of Medical Records at the Surgical Department of a Tertiary Hospital in Blackpool, UK: Results of an Internal Audit
Authors: Mwesigwa Nicolas Wamaani , Mroczek Thomas , Al-Hamid Zaid
Published: April 2023

Introduction: A medical record a fundamental component of a doctor’s roles and responsibilities in providing objective and evidence-based care to his/her patients. It ensures that everyone treating the patients clearly understands the patient’s needs. According to Good Medical Practice & Good Surgical Practice guidelines, medical records should be taken in real time and should be accurate, legible, comprehensive, honest, non-judgmental and up-to-date. In this study we audited medical records at the surgical department of our hospital in the UK to assess the practice of medical records taking at the hospital.

Materials and Methods: This was a follow-up audit to a baseline audit conducted in April 2021.  This study was conducted from 24th January 2022 to 30th January 2022 at the surgical admission unit of Blackpool Victoria Teaching Hospital. A total of 47 sets of records corresponding to 47 emergency surgical take patients were selected and assessed in details against pre-determined assessment criteria. Data was analyzed in Microsoft excel software and summarized inform of count and percentages and presented in bar graphs.

Results: A total of 47 sets of records were assessed for completeness based on the selected parameters. Overall, there was improvement in recording patient ID, recording of reviewing physician’s name, recording of examination findings, recording of patient management plan, and recording of final National early warning score (NEWS). Recording of reviewer name, date, and patient management plan had more than 80% improvement, while the rest were averagely recorded, ranging from 40 to 60%.

Conclusion: The result indicated that documentation in the surgical unit was still inadequate as only three parameters; reviewer name, date and plan were being well recorded. However, there is still a lot of room for improvement and discussions are underway to implement the electronic medical records system.
Genetic and Phenotypic Correlations between Characteristics in Local Guinea Fowl in Ghana
Authors: Duodu Addison
Published: April 2023

This study aimed at estimating genetic and phenotypic correlations among traits in local Guinea fowl in Ghana. Animal farm of Akenten Appiah-Menka University of Skills Training and Entrepreneurial Development Mampong-Ashanti campus was where the study took place, from 2015 to 2018. Data for the experiment was obtained from keets made up of 300 males and 300 females. Parents of the keets consisted of 110 dams and 22 sires. Arithmetic method and Pearson’s product moment correlation were used for the estimates. In male Guinea fowl, the values of genetic correlations among growth characteristics ranged from -0.63 to 0.93. Between growth and other characteristics, estimates of genetic correlation ranged from 0.29 to 0.97, -0.67 to 0.43, -0.62 and 0.94 respectively. Values of phenotypic correlations among growth parameters were between -0.32 and 0.49. Range of figures of phenotypic correlations recorded between growth characteristics and survival, docility, and dressing percentage were between -0.28 and 0.28, -0.46 and 0.18, and -0.41 and 0.36 correspondently. In female Guinea fowl on the other hand, range of genetic correlations among growth traits was between -0.80 and 0.95. Range of figures of genetic correlation between growth traits and survival, docility, dressing percentage and reproductive characteristics of were from -0.47 to 0.9, -0.52 to 0.58, -0.58 to 0.82 and -0.59 to 0.9 respectively. The values of phenotypic correlations among growth characteristics fell between -0.39 and 0.46.  Phenotypic correlations recorded between growth traits and survival, docility, dressing percentage and reproductive characteristics were from -0.26 to 0.47, -0.47 to 0.19, -0.35 to0.47 and -0.33 to 0.47 respectively. Values of genetic correlations higher than one (1) among some traits in male Guinea fowl were recorded. To conclude, discoveries of this study are in general agreement of what pertains to Guinea fowl and other farm livestock species.
Seed Yield Improvement in Vigna unguiculata (L.) (Fabaceae): Efficiency of Pollinators and Impact of Aqueous Leaf Extract of Three Plant Species in North Cameroon
Authors: Mohammadou M. , Adamou M. , Taïmanga  , Kosini D. , Kenne M.
Published: April 2023

Aims: Because of the problems in agroecosystems following the anarchic use of synthetic insecticides, studies propose an alternative, the use of botanical biopesticides against pests.

Study Design: The present study was conducted to evaluate (1) the potential of leaf extract of Calotropis procera (Gentianales: Apocynaceae), Eucalyptus camaldulensis (Myrtales: Myrtaceae) and Tithonia diversifolia (Asterales: Asteraceae) against insects and (2) impact of Apis mellifera (Hymenoptera: Apidae) on Vigna unguiculata (Fabales: Fabaceae) seed yield in North Cameroon.

Place and Duration of Study: A field study was set up in 2021 in North Cameroon, during the rainy season. Fourthy four plots of 4x3.5 m each were distributed according to a randomized complete block design model comprising four untreated, four treated using parastar (40EC 535/10/IN, 20 g/l imidaclopride and 20 g/l lamda-cyhalothrine), and 36 plots treated using 10%, 20%                                 and 30% aqueous leaf extracts separately sprayed against Aphis craccivora (Hemiptera: Aphididae).

Methodology: Four groups of flowers were randomly selected: (1) free, (2) protected from insects, (3) free exclusively to Ap. mellifera and (4) protected against insects.

Results: A total of 10,984 captured flower insects belonged to three orders (Hemiptera, Hymenoptera and Lepidoptera), three families (Aphididae, Apidae and Nymphalidae) and seven species [one (14.3%) sap-sucking Aphis craccivora (Hemiptera: Aphididae), four (57.1%) pollinators Hymenoptera Apidae [Amegilla calens, Amegilla sp., Apis mellifera and Xylocopa olivacea] and two (28.6%) Lepidoptera Nymphalidae [Danaus plexippus and Hypolimnas misippus]. A total of 7,425 insects associated with V. unguiculara corresponded to four orders [Hemiptera (56.7%), Coleoptera (41.5%), Heteroptera and Orthoptera with 0.9% respectively], nine families [Aphididae (45.3%), Chrysomelidae (38.7%), Pyrrhocoridae (4.8%), Coreidae (3.8%), Cicadellidae (2.8%), Coccinellidae (1.9%), Alydidae, Tenebrionidae and Tettigoniidae with 0.9% respectively], 11 genera and 11 species.

Conclusion: Apis mellifera was the major pollinator and Aphis crassivora the major pest. The seed yield was improved by 30% extract of plants without impact on pollinators.
Lactic Acid Inhibits the Cytotoxicity of NK-92 Cells via Activating the Lactate Receptor GPR81
Authors: Huang Yaobiao , Nie Wenjie , Ye Sudan , Chen Chun
Published: April 2023

Aims: Lactate acid functions as not only an energy source but a signaling molecule through the lactate receptor GPR81 under physiological conditions. However, the pathological role of lactic acid in the tumor microenvironment remains unclear, particularly for immune cells.

Methodology: NK-92 cells were treated with L-lactic acid solutions at final concentrations of 10, 20, 30, and 40 mM, and its cell viability and cytotoxicity on A549 cells and A375 cells were evaluated by CCK8 assay and crystal violet assay, respectively. Furthermore, qPCR was used to assess the expression of GPR81 and cytotoxicity-related genes in NK-92 cells treated with antagonist and agonist. And their relationship between lactate/GPR81 pathway and cytotoxicity-related genes were analyzed by Pearson’s correlation.

Results: The viability of NK-92 cells was inhibited by L-lactic acid with increasing concentration. Additionally, the cytotoxic activity against tumor cells of NK-92 cells treated with L-lactic acid decreased with increasing concentration. Moreover, qPCR results demonstrated that GPR81 can be activated by lactic acid or agonist (3,5-DHBA) and downregulate the expression cytotoxicity-related genes which included FASLG gene(Fas Ligand),TNF-α gene(Tumor necrosis factor-α), INFG gene (Interferon-γ), RPF1 gene (Perforin 1), GZMA gene (Granzyme A), GZMB gene (Granzyme B), GZMH gene (Granzyme H), GAMK gene (Granzyme K) and GZMM gene (Granzyme M). And the expression of GPR81 returned to near-control level when treated with L-lactic acid in the presence of antagonist (3-OBA), the expression of cytotoxicity-related genes did as well. Pearson’s correlation analysis of cytotoxicity-related genes with GPR81 revealed that their correlation coefficient seems negative.

Conclusion: Lactic acid can activate the GPR81 to downregulate the expression of cytotoxicity-related genes, subsequently lower the cytotoxicity of NK-92 cells.
Evaluation of Quality Characteristics and Storage Stability of Peanut Beverage Added Ginger, Moringa Leaf Powder and Lime
Authors: Ugbede Ohuoba Elizabeth , Basirat Kelani , Makinde Ayodamola Folake , Nwakaego Eugene Felicia , Ayobami Abolarin Jesuara , Chukwuebuka Igweagu Christian
Published: April 2023

Peanut seeds were roasted at 800C for 20 min milled and blended with ginger (GI),with moringa leaf powder (MP), with lime (LI) with moringa leaf powder and ginger (MG) with lime and moringa leaf powder (LM) with lime and ginger (LM) into paste. Heated water (at 800C) was added to the paste while stirring for 30 min. The mixture was further heated in a boiling bath and filtered with muslin cloth cooled to obtain a drink which was flavored with pineapple, banana and milk flavor and sucrose was also added.

The results showed  moisture content of GI ranged from 79.87 – 83.95 %, with sample LI having the highest value was not significantly different () from MO, MG, LM and LG but sample GI having the lowest value, which was significantly () difference form LI, MG and LG. The ash content ranged from 1.92 – 2.41 %, with sample GI having the highest value which was significantly () different from LI and MG but not significantly () different from other samples. The crude fat content ranged from 2.92 -3.07 %, of which sample GI having the highest value and sample LI having the lowest value which are not significantly () different from one another. The crude protein ranged from 4.01 – 4.74 % of which sample GI having the highest value and sample LG having the least value which are not significantly () different from one another. The carbohydrate contents ranged from 3.49 – 6.49 % with sample LI had the highest value which was not significantly () different from sample GI and MO and sample MG having the lowest value which was significantly () difference from other sample except LG. pH of beverages decreased from 7.90 MG week 1 to 3.21 in LM in week 3.Total titretable acidity  present in the beverages were GI in week 1; (0.13), MO(0.17), LI(0.18), MG(0.12), LM(0.19) and LG(0.16).At week 3, GI(0.18), MO(0.23), LI(O.24), MG(0.82), LM(0.24) and LG(0.24). The beverages contained low number of total plate counts (1.9 x 102 - 2.8 x 104) and fungi/yeasts counts (1.2 x 104- 4.2 X 106). Overall acceptability was high for all samples.
A Study on Mushroom Production in India and Odisha Vis a Vis Global Level
Authors: Rath Surya Sidhant , Mishra Sarba Narayan
Published: April 2023

In the 21st century, mushroom is seen as the favoured alternate source of food that would help compensate scarcity of nutritious food as mushroom is grown indoors using vertical space and more specifically address the issues of environment sustainability due to recycling of farm wastes. Mushrooms which were earlier found in the forest and forest areas have now been the most prolific and versatile agricultural and horticultural venture. The current study has been undertaken to study the comparative trends in mushroom growth in Odisha, India and world. China is the leading mushroom producer in the world with a lion share of ninety three per cent while India ranks at sixth position with a contribution of slightly more than half a per cent. Odisha, Bihar, Maharastra contribute nearly one third mushroom production in India. In Odisha four districts i.e., Puri, Ganjam, Khurda, Dhenkanal contribute sixty per cent of total mushroom production in the state. The study indicated that the (Compounded Annual Growth Rate) CAGR of world, India and Odisha in mushroom production from 2013-2022 is three, thirty six and sixteen per cent respectively Rajasthan is witnessing a new dawn in mushroom production as it contributed only one per cent with 1300 tons in 2018, is now contributing five per cent with 15000 tons in 2022 with a CAGR of sixty six per cent. Even if with the favourable climatic condition, production of mushroom in the north eastern states of India is negligible. The button mushroom which is the highest contributor in India with seventy three percent contributes only eleven per cent in the world level and one per cent in Odisha. Similarly paddy straw mushroom that contributes almost sixty six per cent in Odisha has a meagre contribution of only one per cent in the global level and seven per cent in India. Oyster mushroom has a uniform share of twenty six per cent in the world, sixteen per cent in India and thirty three per cent in Odisha. It may be estimated that if the current growth rate continues then in the next five years by 2027 the world mushroom production will be around fifty million tons, while the mushroom production in India and Odisha would stand at around six lakhs tons and sixty five thousand tons respectively.
Study of Productivity and Economics of Sunflower (Helianthus annuus L.) var. KBSH – 1 as Influenced by Nitrogen and Spacing
Authors: Sandhya Eslavath , Singh Rajesh
Published: April 2023

A field experiment was conducted to determine the influence of Nitrogen and Spacing levels on Sunflower (Helianthus annuus L.) var. during kharif season of 2022, with 10 treatments (1-9) with different treatment combination of nitrogen and spacing and T10 is control. (viz. Nitrogen at 50, 60, and 70 kg/ha with 45 X 20 cm , 55 X 20 cm , 65 X 20 cm respectively). The soil experimental plot was sandy loam in texture, nearly neutral in soil reaction (Ph 7.1), low in organic carbon (0.28%), available N (225kg/ha), available P (19.50kg/ha) and K (92kg/ha) at crop research farm of Department of Agronomy at Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj to study the effect of nitrogen and spacing on growth, yield and economics of Sunflower (Helianthus annuus L.) Var. KBSH - 1, The result revealed that application of 70 kg N/ha + 45 X 20 cm  recorded maximum Capitulum diameter (15.13 cm), seed yield (2102 kg/ha). Stover yield (4287.92 kg/ha), oil content (42.27%) gross return (126.120 X 103INR/ha) highest net return (88.737x 103 INR/ha) and benefit: cost ratio (2.37%).
Evaluation of Detrusor Contractility Parameters Help to Analyze Consequences of Steady Abdominal Pressure Changes during Voiding in Women
Authors: Valentini Françoise A. , Marti Brigitte G. , Robain Gilberte
Published: April 2023

Introduction: Urodynamic study interpretation leading to urodynamic diagnosis is mainly based on pressure recordings and the value of detrusor pressure at maximum flow (pdet.Qmax). Detrusor pressure is calculated by subtracting the abdominal pressure (pabd) from the vesical pressure (pves). Hence, there is a critical role for pabd in this process. The goal of our study was evaluate the contribution of detrusor contractility parameters (DCP) to confirm and to correct urodynamic misdiagnosis (UmD) due to steady abdominal pressure changes during voiding in women.

Materials and Methods: Urodynamic tracings of 271 non-neurologic women referred for investigation of various LUTS were retrospectively analyzed. UmD could be bladder outlet obstruction (BOO) and normal (N) for decreased pabd, normal (N) and detrusor underactivty (DU) for increased pabd. Detrusor contractility parameters were VBN parameter k and PIP1.

Results: Among the whole population 125 women had a significant change (≥5 cmH2O) of pabd during voiding (73 decrease, 52 increase).

In the “decrease” sub-group, only 3 N became DU with decreased DCP values; in the “increase” sub-group 1 N and 1 DU patients gained BOO diagnosis with increased DCP values.

In total, analysis of changes in abdominal pressure leads to 5/271 (1.8%) changes in urodynamic diagnosis; no correlation between previous surgery of incontinence or main complaint.

Conclusion: A high percentage of the non-neurologic female population has steady changes of abdominal pressure during voiding, that condition leads to few changes in urodynamic diagnosis; evaluation of detrusor contractility parameters values help to verify the new conclusions.
Hematological and Hypoglycemic Effects of Ethanolic Extract of Annona muricata Ripe Fruits Pulp on Streptozotocin-induced Diabetes in Rats: In vivo and In silico Studies
Authors: Akinlolu O. S. , Fatoki T. H. , Momodu D. U.
Published: April 2023

Diabetes mellitus has been a metabolic disorder characterized by interferences in the breakdown of carbohydrate, lipid, and protein as a result of insulin deficiency. Great efforts are ongoing in understanding and management of diabetes, and disease related complication. In this work, an attempt was made to study the hematological and hypoglycemic effects of Annona muricata ripe fruits pulp in Streptozotocin (STZ)-induced diabetic rats and validates its traditional claim.  The forty-eight (48) Albino rat were divided into six groups which include normal, tests and controls. The diabetes–induced rats were fed orally with A. muricata ripe fruits pulp extract in concentrations of 750 mg, 1000 mg, and 2000 mg respectively. The results showed that the extract caused fasting blood sugar glucose levels to remarkably reduced to near normal. Hematological studies revealed that there were improvements in the hematological indices tested groups when compare with diabetes normal group. The molecular docking results indicate that the phytochemicals in A. muricata ripe fruit pulp have more affinity for aldose reductase followed by alpha-amylase and then alpha-glucosidase, and that montecristin, epoxymurin-A, dicaffeoylquinic acid, and kaempferol 3-O-rutinoside show higher affinity to the three targets than acarbose. These results indicate that ripe fruits pulp of A. muricata possesses a strong hypoglycemic effect in STZ–induced diabetic rats, thus supporting its traditional use in the management of diabetes mellitus.
“The Art of the Craft,” From The Covenant of Water
Authors: Verghese Abraham
Published: April 2023

This Arts and Medicine feature excerpts a chapter from The Covenant of Water, the new novel from Abraham Verghese, which follows the lives of a family in South India over the 20th century who have a “condition” that consigns at least 1 member per generation to death by drowning.
Severe Maternal Morbidity and Mortality of Pregnant Patients With COVID-19 Infection During the Early Pandemic Period in the US
Authors: Matsuo Koji , Green Jessica M. , Herrman Sarah A. , Mandelbaum Rachel S. , Ouzounian Joseph G.
Published: April 2023

This cohort study examines the patient characteristics and maternal outcomes associated with COVID-19 infection among pregnant patients at delivery during the early pandemic period in the US.
Effect of Using CuO–Oil Nanofluid on Surface Roughness and Thermal Performance during Superfinishing Process
Authors: Naghizadeh Hasan , Nosouhi Reza , Badiezadegan Seyed Adel , Soleymani Milad , Azadi Amir Mohammad , Azimy Noushin , Azimy Hamidreza
Published: April 2023

This research aims to investigate the effect of adding copper oxide nanoparticles to the oil Gr‐6004 base fluid and its concentration changes from 0.1% to 0.4% on the surface roughness of gudgeon pin and the thermal conductivity of the nanofluids during the superfinishing process. The main novelty of this investigation is analyzing the impact of utilizing CuO/oil Gr‐6004 nanofluid on thermal conductivity of oil and surface quality of gudgeon pin during superfinishing process. Based on the results, adding nanoparticles to the oil Gr‐6004 has significantly reduced the surface roughness. In addition, by increasing the concentration of nanoparticles to 0.4%, the surface roughness has decreased by 57% compared to oil Gr‐6004. Also, by adding nanoparticles, the thermal conductivity of the nanofluids has increased to 19.5%. In addition, dispersing CuO nanoparticles into base fluid reduces oil temperature by 17.44%.
Multifaceted Roles of Copper Ions in Anticancer Nanomedicine
Authors: Yang Siyuan , Song Yingnan , Hu Yanling , Chen HongJin , Yang Dongliang , Song Xuejiao
Published: April 2023

The significantly increased copper level in tumor tissues and serum indicates the close association of copper ions with tumor development, making copper ions attractive targets in the development of novel tumor treatment methods. The advanced nanotechnology developed in the past decades provides great potential for tumor therapy, among which Cu‐based nanotherapeutic systems have received greater attention. Herein, the multifaceted roles of copper ions in cancer progression are summarized and the recent advances in the copper‐based nanostructures or nanomedicines for different kinds of tumor therapies including copper depletion therapy, copper‐based cytotoxins, copper‐ion‐based chemodynamic therapy and its combination with other treatments, and copper‐ion‐induced ferroptosis and cuproptosis activation are discussed. Furthermore, the perspectives for the further development of copper‐ion‐based nanomedicines for tumor therapy and clinic translation are presented by the authors.
Rapid and Scalable Transfer of Large‐Area Graphene Wafers
Authors: Hu Zhaoning , Li Fangfang , Wu Haotian , Liao Junhao , Wang Quan , Chen Ge , Shi Zhuofeng , Zhu Yaqi , Bu Saiyu , Zhao Yixuan , Shang Mingpeng , Lu Qi , Jia Kaicheng , Xie Qin , Wang Guorui , Zhang Xiaodong , Zhu Yinbo , Wu Hengan , Peng Hailin , Lin Li , Liu Zhongfan
Published: April 2023

Recently, scalable production of large‐area graphene films on metal foils with promising qualities is successfully achieved by eliminating grain boundaries, wrinkles, and adlayers. The transfer of graphene from growth metal substrates onto functional substrates remains one inescapable obstacle on the road to the real commercial applications of chemical vaport deposition (CVD) graphene films. Current transfer methods still require time‐consuming chemical reactions, which hinders its mass production, and produces cracks and contamination that strongly impede performance reproducibility. Therefore, graphene transfer techniques with fine intactness and cleanness of transferred graphene, and improved production efficiency would be ideal for the mass production of graphene films on destination substrates. Herein, through the engineering of interfacial forces enabled by sophisticated design of transfer medium, the crack‐free and clean transfer of 4‐inch‐sized graphene wafers onto silicon wafers within only 15 min is realized. The reported transfer method is an important leap over the long‐lasting obstacle of the batch‐scale graphene transfer without degrading the quality of graphene, bringing the graphene products close to the real applications.
A Highly Robust Amphibious Soft Robot with Imperceptibility Based on a Water‐Stable and Self‐Healing Ionic Conductor
Authors: Cheng Zhe , Feng Wenwen , Zhang Yucheng , Sun Lin , Liu Yuncong , Chen Lili , Wang Chao
Published: April 2023

Dielectric elastomer actuators (DEAs) are widely exploited for actuating soft machines and granting soft robots with capability to operate in both underwater and on‐land environments is important to make them adapt to more complex situations. Here, a DEA‐driven, highly robust, amphibious imperceptible soft robot (AISR) based on an all‐environment stable ionic conductive material is presented. A soft, self‐healable, all‐environment stable ionic conductor is developed by introducing cooperative ion–dipole interactions to provide underwater stability as well as efficient suppression of ion penetration. By tuning molecular structures of the material, a 50‐time device lifetime increase compared with unmodified [EMI][TFSI]‐based devices and excellent underwater actuating performance is achieved. With the synthesized ionic electrode, the DEA‐driven soft robot exhibits amphibious functionality to traverse hydro‐terrestrial regions. When encountering damage, the robot shows good resilience and can self‐heal underwater and it also exhibits imperceptibility to light, sound, and heat.
Achieving Practical High‐Energy‐Density Lithium‐Metal Batteries by a Dual‐Anion Regulated Electrolyte
Authors: Su Hai , Chen Zifeng , Li Mengjie , Bai Panxing , Li Yong , Ji Xiao , Liu Ziqiang , Sun Jie , Ding Jia , Yang Ming , Yao Xiayin , Mao Chong , Xu Yunhua
Published: April 2023

Lithium‐metal batteries (LMBs) using lithium‐metal anodes and high‐voltage cathodes have been deemed as one of the most promising high‐energy‐density battery technology. However, its practical application is largely hindered by the notorious dendrite growth of lithium‐metal anodes, the fast structure degradation of the cathode, and insufficient electrode–electrolyte interphase kinetics. Here, a dual‐anion regulated electrolyte is developed for LMBs using lithium bis(trifluoromethylsulfonyl)imide (LiTFSI) and lithium difluoro(bisoxalato)phosphate (LiDFBOP) as anion regulators. The incorporation of TFSI− in the solvation sheath reduces the desolvation energy of Li+, and DFBOP− promotes the formation of highly ion‐conductive and sustainable inorganic‐rich interphases on the electrodes. Significantly enhanced performance is demonstrated on Li||LiNi0.83Co0.11Mn0.06O2 pouch cells, with 84.6% capacity retention after 150 cycles in 6.0 Ah pouch cells and an ultrahigh rate capability up to 5 C in 2.0 Ah pouch cells. Furthermore, a pouch cell with an ultralarge capacity of 39.0 Ah is fabricated and achieves an ultrahigh energy density of 521.3 Wh kg−1. The findings provide a facile electrolyte design strategy for promoting the practical utilization of high‐energy‐density LMBs.