bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Transcriptome Analysis Suggests Key Roles for 5-Hydroxytryptamlne Receptors in Control of Goose Egg Production
Authors: Ouyang Qingyuan , Hu Shenqiang , Wang Guosong , Hu Jiwei , Zhang Jiaman , Li Liang , Hu Bo , He Hua , Liu Hehe , Xia Lu , Wang Jiwen
Published: April 2020

To date, research on poultry egg production performance has only been conducted within inter or intra-breed groups, while those combining both inter- and intra-breed groups are lacking. Egg production performance is known to differ markedly between Sichuan white goose (Anser cygnoides) and Landes goose (Anser anser). In order to understand the mechanism of egg production performance in geese, we undertook this study. Here, 18 ovarian stromal samples from both Sichuan white goose and Landes goose at the age of 145 days (3 individuals before egg production initiation for each breed) and 730 days (3 high- and low egg production individuals during non-laying periods for each breed) were collected to reveal the genome-wide expression profiles of ovarian mRNAs and lncRNAs between these two geese breeds at different physiological stages. Briefly, 58, 347, 797, 777, and 881 differentially expressed genes (DEGs) and 56, 24, 154, 105, and 224 differentially expressed long non-coding RNAs (DElncRNAs) were found in LLD vs. HLD (low egg production Landes goose vs. high egg production Landes goose), LSC vs. HSC (low egg production Sichuan White goose vs. high egg production Sichuan white goose), YLD vs. YSC (young Landes goose vs. young Sichuan white goose), HLD vs. HSC (high egg production Landes goose vs. high egg production Sichuan white goose), and LLD vs. LSC (low egg production Landes goose vs. low egg production Sichuan white goose) groups, respectively. Functional enrichment analysis of these DEGs and DElncRNAs suggest that the “neuroactive ligand–receptor interaction pathway” is crucial for egg production, and particularly, members of the 5-hydroxytryptamine receptor (HTR) family affect egg production by regulating ovarian metabolic function. Furthermore, the big differences in the secondary structures among HTR1F and HTR1B, HTR2B, and HTR7 may lead to their different expression patterns in goose ovaries of both inter- and intra-breed groups. These results provide novel insights into the mechanisms regulating poultry egg production performance.
Gastroparesis in the Pediatric Patient: Children Are Not Little Adults
Authors: Lu Peter L. , Di Lorenzo Carlo
Published: April 2020

Although the definition of gastroparesis in children is the same as in adults, there are key differences between gastroparesis in these two populations in presentation, diagnosis, treatment and outcomes. Infants and younger children with gastroparesis tend to be male, present with vomiting as their primary symptom and are more likely to experience the resolution of their symptoms over time. Adolescents with gastroparesis tend to be female, present with abdominal pain as their primary symptom and have a less favorable short- and medium-term outcome, sharing some similarities with adults with gastroparesis. Despite the fact that validated diagnostic criteria for gastroparesis are lacking in infants and younger children, these age groups make up nearly half of children with gastroparesis in some studies. The diagnosis and treatment of children with gastroparesis has thus far relied heavily on research studies performed in adults, but it is becoming increasingly clear that gastroparesis in children is a distinct entity and there are limitations to the applicability of data obtained from adults to the care of children.
Impact of Self-Reported Sitting Time and Transtheoretical Model Based on Exercise Behavior Change on Glycemic and Weight Control in Japanese Adults with Type 1 Diabetes: A Cross-Sectional Study
Authors: Honda Hiroto , Igaki Makoto , Tanaka Shin-ichiro , Ono Kumiko , Hirota Yushi
Published: April 2020

This cross-sectional study aimed to examine the associations among self-reported sitting time (ST), transtheoretical model (TTM) based on exercise behavior change, and glycemic and weight control in Japanese adults with type 1 diabetes (T1D). Forty-two adults (age, 44.0 (33.3–56.8) years) with uncomplicated T1D answered questions regarding their lifestyles, including ST per day, and TTM using self-administered questionnaires. The glycated hemoglobin (HbA1c) level correlated with age and ST (p < 0.05, p < 0.01, respectively), whereas body mass index correlated with duration of T1D and TTM (p < 0.05, p < 0.01, respectively). Logistic regression analysis showed that poor glycemic control (HbA1c, >7%) was associated with ST (odds ratio, 3.53 (95% confidence interval, 1.54–8.11), p < 0.01). In addition, the cut-off points for quartiles of ST were 4.6, 6.0, and 8.0 h/day, and the HbA1c level in the lowest quartile was 15% lower than that in the highest quartile (p < 0.01). Although further studies with larger samples are needed, these results implied that expanded self-reported ST might be related to poor glycemic control in Japanese T1D adults, most of whom were lean, young and middle-aged, regardless of TTM based on exercise behavior change.
The Experience of Using Video Support in Ambulance Care: An Interview Study with Physicians in the Role of Regional Medical Support
Authors: Vicente Veronica , Johansson Anders , Ivarsson Bodil , Todorova Lizbet , Möller Sebastian
Published: April 2020

Background: In order to facilitate more effective patient assessment and diagnostic support by improving the flow of information between ambulance nurses (AN) and physicians in the role of regional medical support (RMS), an application was developed for transmitting real-time video images. Objective: The objective of this study was to elucidate the physicians’ experiences using a video application to support the assessment and triage procedure in ambulance care, when patients are deemed to not have an urgent need for emergency care. Design: The design for this research was a qualitative interview study. Ten physicians, working as RMS in ambulance care, were purposively selected to participate. The telemedicine concept studied consisted of a real-time video image application, in addition to the currently used mobile phone. When a patient was deemed eligible for inclusion in the study, the ambulance nurse (AN) contacted the RMS via telephone to initiate a video consultation. To elucidate the RMS experience of using the application, a conventional content analysis was performed. Results: The main theme “a feeling of being satisfied through a sense of increased patient safety” emerged from the following two categories: adds value in diagnosing situations (three subcategories, i.e., support in diagnosing, usability, and technical weakness) and increase communication opportunities (four subcategories, i.e., assessing the level of care, patient dialogue, professional communication, and team learning). Conclusions: Physicians in the role of RMS experienced a positive impact using video image transmission in addition to the currently used mobile phone. This evaluation was derived from a sense of increased patient safety in the assessment situation when patients were considered to be triaged to self-care.
Noise Exposure and Hearing Loss among Brewery Workers in Lagos, Nigeria
Authors: Wouters Nino L. , Kaanen Charlotte I. , den Ouden Petronella J. , Schilthuis Herbert , Böhringer Stefan , Sorgdrager Bas , Ajayi Richard , de Laat Jan A. P. M.
Published: April 2020

The health risks of exposure to loud noises are a well-established fact and are widely addressed in modern industries. Yet, in less developed countries, it is thought these hazards receive less attention, both in the workplace and in private life. (1) Background: The aim of this study is to assess the occupational noise exposure in a developing country and identify possible risk groups for whom intervention is needed. (2) Methods: A cross-sectional study was performed among brewery employees in Lagos, Nigeria. Pure-tone audiometry (PTA) was performed, paired with a self-report questionnaire. Personal noise dosimetry (PND) was also performed with an additional group of participants. (3) Results: A total of 458 employees were submitted to PTA. The Packaging and Utilities department reported the largest shifts in hearing thresholds (18 dB [sd = 15] and 16 dB [sd = 15] @4kHz, respectively). No significant effect of department type on auditory health could be found. PND results were obtained from 39 employees. Packaging and Sales were identified as the most exposed departments. (4) Conclusions: A healthy hearing profile was found for a large proportion of the brewery employees (91.7%). However, NIHL (noise-induced hearing loss) proportions specifically among Bottling and Sales employees were elevated.
The Effects of Cyanobacterial Bloom Extracts on the Biomass, Chl-a, MC and Other Oligopeptides Contents in a Natural Planktothrix agardhii Population
Authors: Toporowska Magdalena , Mazur-Marzec Hanna , Pawlik-Skowrońska Barbara
Published: April 2020

Blooms of the cyanobacterium Planktothrix agardhii are common in shallow, eutrophic freshwaters. P. agardhii may produce hepatotoxic microcystins (MCs) and many other bioactive secondary metabolites belonging mostly to non-ribosomal oligopeptides. The aim of this work was to study the effects of two extracts (Pa-A and Pa-B) of P. agardhii-predominated bloom samples with different oligopeptide profiles and high concentration of biogenic compounds on another natural P. agardhii population. We hypothesised that the P. agardhii biomass and content of oligopeptides in P. agardhii is shaped in a different manner by diverse mixtures of metabolites of different P. agardhii-dominated cyanobacterial assemblages. For this purpose, the biomass, chlorophyll a and oligopeptides content in the treated P. agardhii were measured. Seven-day microcosm experiments with four concentrations of the extracts Pa-A and Pa-B were carried out. Generally, aeruginosins (AERs), cyanopeptolins (CPs) and anabaenopeptins (APs) were the most numerous peptides; however, only 16% of them were common for both extracts. The addition of the extracts resulted in similar effects on P. agardhii: an increase in biomass, Chl-a and MC content in the exposed P. agardhii as well as changes in its oligopeptide profile were observed. MCs present in the extracts did not inhibit accumulation of P. agardhii biomass, and did not have any negative effect on MC and Chl-a content. No evidence for bioaccumulation of dissolved peptides in the P. agardhii exposed was found. As the two tested extracts differed considerably in oligopeptide composition, but contained similar high concentrations of nutrients, it seems that biogenic compounds, not oligopeptides themselves, positively influenced the mixed natural P. agardhii population.
Validity and Reliability of a New Inertial Device for Monitoring Range of Motion at the Pelvis during Sexual Intercourse
Authors: Oliva-Lozano José M. , Martín-Fuentes Isabel , Muyor José M.
Published: April 2020

To understand the physical demands of sexual intercourse, it is necessary to monitor the kinematic parameters of this activity using relatively non-invasive technology. The aims of this study are to analyze the validity and reliability of an inertial device for monitoring the range of motion at the pelvis during simulated intercourse and compare the range of motion (ROM). Twenty-six adults were monitored during intercourse using an inertial device (WIMU) and a motion capture system (gold standard) in a test that consisted of 4 sets of 20 simulated in–out cycles (IOC) in missionary and cowgirl positions. Men and women were tested separately in a laboratory setting for simulated intercourse aims. There were no differences between the WIMU and the gold standard system at fast pace (p > 0.05), whereas there were differences at slow pace (~2.04°; p ≤ 0.05; d = 0.17). Intraclass correlation coefficients (ICCs) for the relationship between systems was very close to 1 at both paces (slow: 0.981; fast: 0.998). The test–retest reliability analysis did not show any difference between sets of measurements. In conclusion, WIMU could be considered as a valid and reliable device for IOC range of motion monitoring during sexual intercourse in missionary and cowgirl positions.
Organizational Health Literacy in Facilities for People with Disabilities: First Results of an Explorative Qualitative and Quantitative Study
Authors: Rathmann Katharina , Vockert Theres , Wetzel Lorena Denise , Lutz Judith , Dadaczynski Kevin
Published: April 2020

To date, studies on individual and organizational health literacy (OHL) in facilities for people with disabilities are scarce. Thus, the aims of this study are (1) to adapt an existing instrument for measuring organizational health literacy (OHL), namely, the “Health literate health care organization scale” (HLHO-10), to the context of facilities for people with disabilities, (2) to quantitatively examine characteristics of OHL, and (3) to qualitatively assess the definition and role of OHL by interviewing managers and skilled staff. An online study in Germany with N = 130 managers and skilled staff in facilities for people with disabilities was conducted, using the adapted HLHO-10 questionnaire. Univariate analyses were applied. Qualitative content analysis was used to investigate interview data from N = 8 managers and skilled staff from N = 8 facilities for people with disabilities in Hesse, Germany. Quantitative results revealed that respondents reported a below-average level in HLHO-10, with the lowest level found in the attribute of participative development of health information. The qualitative findings showed a clear need for improved navigation to and in facilities. The quantitative and qualitative findings are mainly consistent. Future research and measures should focus on facilities for people with disabilities in order to strengthen the development of and access to target-group-specific health information, as well as to establish a health-literate working and living environment.
Heavy Metal Uptake of Lettuce and Ryegrass from Urban Waste Composts
Authors: Paradelo Remigio , Villada Antía , Barral María Teresa
Published: April 2020

Interest in using urban waste composts as amendments in urban agriculture is growing nowadays. However, concerns about the potential transference of pollutants present in urban waste to the food chain are very relevant when they are recycled for food or animal feed production. Thus, for the safe use of urban waste composts, it has to be assured that no risk of metal transference to plants from compost exists. In this work, the transference of heavy metals from urban waste composts to plants has been studied in an experiment with lettuce and Italian ryegrass, grown in substrates based on five metal-rich composts and a manure vermicompost (included for comparison). A two-month pot experiment was performed under controlled light and temperature conditions, and plant growth and uptake of Cu, Pb, Cd and Zn were analyzed. For both species, the concentration of metals in plant tissue followed the sequence Zn > Cu >> Pb ≈ Cd, the same as the metal concentrations in four out of the five composts. Plant concentrations of Zn, Cu and Cd increased with their concentrations in compost, whereas this relation was not observed for Pb. The ratio between element concentration in plant and compost were much higher for Zn, Cd and Cu than for Pb, showing the lower bioavailability of Pb with respect to other metals.
The Spatial Distribution Characteristics of Soil Organic Carbon and Its Effects on Topsoil under Different Karst Landforms
Authors: Wang Xingfu , Huang Xianfei , Hu Jiwei , Zhang Zhenming
Published: April 2020

Karst landforms are widely distributed in Guizhou Province, and the karst terrain is complex. To investigate the spatial distribution characteristics of soil organic carbon (SOC) in topsoil in different karst landforms, a total of 920 samples were taken from different karst landforms. The study areas, Puding, Xingyi, Guanling, Libo and Yinjiang in Guizhou Province, represent the karst plateau (KP), karst peak-cluster depression (KPCD), karst canyon (KC), karst virgin forest (KVF) and karst trough valley (KTV) landforms, respectively. The characteristics of the SOC contents in areas with different vegetation, land use and soil types under different karst landforms were analyzed. The dimensionality of the factors was reduced via principal component analysis, the relationships among SOC content and different factors were subjected to redundancy analysis, and the effects of the main impact factors on SOC were discussed. The results showed that there was a large discrepancy in the SOC contents in the topsoil layers among different types of karst landforms, the changes in the SOC content in the topsoil layer were highly variable, and the discrepancy in the upper soil layer was higher than that in the lower soil layer. The SOC contents in the 0–50 cm topsoil layers in different karst landforms were between 7.76 and 38.29 g·kg−1, the SOC content gradually decreased with increasing soil depth, and the descending order of the SOC contents in different karst landforms was KTV > KVF > KC > KPCD > KP.
Breath Alcohol Concentration and Perception of Drunkenness: A Comparison between Adolescents and Young Adults Drinking Alcohol in Public Settings
Authors: Gervilla Elena , Jiménez Rafael , Anupol Joella , Duch Mariàngels , Sesé Albert
Published: April 2020

Alcohol use is a persisting social and health problem in Spain that often takes place within the recreational context. This study aims to analyze objective and self-reported measures of alcohol use and to assess the potential role of social factors on alcohol intake in open-air public settings. A total of 1475 participants (47.4% women), including 27.8% adolescents organized into 355 natural groups of friends, were interviewed while they were socializing at night in the streets of Palma (Spain). Breath alcohol concentration (BrAC), self-reported measures of alcohol use, and social variables were assessed. Men showed statistically higher scores in BrAC than women. However, adolescents’ Alcohol Use Disorders Identification Test (AUDIT) scores were not statistically different by gender. Correlation between objective and self-reported measures was low. Interestingly, BrAC of drinkers was lower when some friends in the group were sober. Moreover, especially in young adults, variables related to the social environment were statistically significant factors to predict BrAC. In conclusion, we found a high prevalence of alcohol intake in young people in open-air public settings, low relationship of objective and self-reported measures, and social factors linked to alcohol use, although differences by age and gender must be considered.
Connectivity of Real-Time Video Counselling Versus Telephone Counselling for Smoking Cessation in Rural and Remote Areas: An Exploratory Study
Authors: Byaruhanga Judith , Paul Christine L. , Wiggers John , Byrnes Emma , Mitchell Aimee , Lecathelinais Christophe , Tzelepis Flora
Published: April 2020

This study compared the connectivity of video sessions to telephone sessions delivered to smokers in rural areas and whether remoteness and video app (video only) were associated with the connectivity of video or telephone sessions. Participants were recruited into a randomised trial where two arms offered smoking cessation counselling via: (a) real-time video communication software (201 participants) or (b) telephone (229 participants). Participants were offered up to six video or telephone sessions and the connectivity of each session was recorded. A total of 456 video sessions and 606 telephone sessions were completed. There was adequate connectivity of the video intervention in terms of no echoing noise (97.8%), no loss of internet connection during the session (88.6%), no difficulty hearing the participant (88.4%) and no difficulty seeing the participant (87.5%). In more than 94% of telephone sessions, there was no echoing noise, no difficulty hearing the participant and no loss of telephone line connection. Video sessions had significantly greater odds of experiencing connectivity difficulties than telephone sessions in relation to connecting to the participant at the start (odds ratio, OR = 5.13, 95% confidence interval, CI 1.88–14.00), loss of connection during the session (OR = 11.84, 95% CI 4.80–29.22) and hearing the participant (OR = 2.53, 95% CI 1.41–4.55). There were no significant associations between remoteness and video app and connectivity difficulties in the video or telephone sessions. Real-time video sessions are a feasible option for smoking cessation providers to provide support in rural areas.
Predictors of Health Insurance Enrollment among HIV Positive Pregnant Women in Kenya: Potential for Adverse Selection and Implications for HIV Treatment and Prevention
Authors: Were Lawrence P.O. , Hogan Joseph W , Galárraga Omar , Wamai Richard
Published: April 2020

Background: The global push to achieve the 90-90-90 targets designed to end the HIV epidemic has called for the removing of policy barriers to prevention and treatment, and ensuring financial sustainability of HIV programs. Universal health insurance is one tool that can be used to this end. In sub-Saharan Africa, where HIV prevalence and incidence remain high, the use of health insurance to provide comprehensive HIV care is limited. This study looked at the factors that best predict social health insurance enrollment among HIV positive pregnant women using data from the Academic Model Providing Access to Healthcare (AMPATH) in western Kenya. Methods: Cross-sectional clinical encounter data were extracted from the electronic medical records (EMR) at AMPATH. We used univariate and multivariate logistic regressions to estimate the predictors of health insurance enrollment among HIV positive pregnant women. The analysis was further stratified by HIV disease severity (based on CD4 cell count <350 and 350>) to test the possibility of differential enrollment given HIV disease state. Results: Approximately 7% of HIV infected women delivering at a healthcare facility had health insurance. HIV positive pregnant women who deliver at a health facility had twice the odds of enrolling in insurance [2.46 Adjusted Odds Ratio (AOR), Confidence Interval (CI) 1.24–4.87]. They were 10 times more likely to have insurance if they were lost to follow-up to HIV care during pregnancy [9.90 AOR; CI 3.42–28.67], and three times more likely to enroll if they sought care at an urban clinic [2.50 AOR; 95% CI 1.53–4.12]. Being on HIV treatment was negatively associated with health insurance enrollment [0.22 AOR; CI 0.10–0.49]. Stratifying the analysis by HIV disease severity while statistically significant did not change these results. Conclusions: The findings indicated that health insurance enrollment among HIV positive pregnant women was low mirroring national levels. Additionally, structural factors, such as access to institutional delivery and location of healthcare facilities, increased the likelihood of health insurance enrollment within this population. However, behavioral aspects, such as being lost to follow-up to HIV care during pregnancy and being on HIV treatment, had an ambiguous effect on insurance enrollment. This may potentially be because of adverse selection and information asymmetries. Further understanding of the relationship between insurance and HIV is needed if health insurance is to be utilized for HIV treatment and prevention in limited resource settings.
Evidence Supports PA Prescription for Parkinson’s Disease: Motor Symptoms and Non-Motor Features: A Scoping Review
Authors: Cheng Yi-Chen , Su Chun-Hsien
Published: April 2020

Parkinson’s disease (PD) is a prevalent neurodegenerative disorder, which relates to not only motor symptoms, but also cognitive, autonomic, and mood impairments. The literature suggests that pharmacological or surgical treatment has a limited effect on providing relief of the symptoms and also restricting its progression. Recently, research on non-pharmacological interventions for people living with PD (pwPD) that alleviate their motor and non-motor features has shown a new aspect in treating this complex disease. Numerous studies are supporting exercise intervention as being effective in both motor and non-motor facets of PD, such as physical functioning, strength, balance, gait speed, and cognitive impairment. Via the lens of the physical profession, this paper strives to provide another perspective for PD treatment by presenting exercise modes categorized by motor and non-motor PD symptoms, along with its effects and mechanisms. Acknowledging that there is no “one size fits all” exercise prescription for such a variable and progressive disease, this review is to outline tailored physical activities as a credible approach in treating pwPD, conceivably enhancing overall physical capacity, ameliorating the symptoms, reducing the risk of falls and injuries, and, eventually, elevating the quality of life. It also provides references and practical prescription applications for the clinician.
Ladder Safety: A Taxonomy of Limb-Movement Patterns for Three Points of Control
Authors: Jensen Roger C. , Holland Charles J.
Published: April 2020

Traditional guidance on ladder safety emphasizes training workers on the use of three points of contact. More recent guidance is to train workers to use three points of control. What is lacking is empirical information about what limb-movement patterns effectively support the use of three points of control. This project was conducted to establish a taxonomy of possible limb-movement patterns and a means for comparing relative safety. Prior to the experiment, a taxonomy of six possible limb-movement patterns was established. A sample of 20 undergraduate students performed four tasks each without any instructions on limb-movement pattern. The tasks were ascending and descending a straight ladder and a portable ladder, once each, while being videotaped. Out of 80 observed tasks, 59 of the subjects were using rungs rather than rails. Analysis of rung users identified the use of all six patterns. An innovative measure of safe performance was developed and used to compare the patterns. Statistical analysis did not find significant differences in the patterns based on the safety performance measure.
Associations of Genetic Variation in Glyceraldehyde 3-Phosphate Dehydrogenase Gene with Noise-Induced Hearing Loss in a Chinese Population: A Case-Control Study
Authors: Wan Liu , Wang Boshen , Zhang Juan , Zhu Baoli , Pu Yuepu
Published: April 2020

Objective: The purpose of this paper was to clarify the association between genetic variation in the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) gene and the risk of noise-induced hearing loss (NIHL). Methods: A case-control study (633 cases and 625 controls) was conducted in this study. Logistic regression was used to analyze the relationships between environmental and individual factors and NIHL. Gene expression levels were compared among each GAPDH rs6489721 genotype and between the case and control groups based on real-time fluorescence quantitative Polymerase Chain Reaction (PCR). Results: The T allele of GADPH rs6489721 was significantly associated with NIHL (odds ratio (OR) = 1.262, 95% confidence interval (CI) (1.066, 1.493), p = 0.006) and showed strong associations in the codominant and dominant models (TT vs. CC: OR = 1.586, 95% CI (1.131, 2.225), p = 0.008; TT vs. TC/CC: OR = 1.391, 95% CI (1.073, 1.804), p = 0.013). The expression level of the TT genotype was significantly higher than that of the CC genotype (p = 0.012), and the expression of the case group was also higher than that of the control group (p = 0.013). Conclusions: The homozygous risk allele (TT) of rs6489721 was associated with an enhanced GAPDH expression, resulting in the development of NIHL in a Chinese population.
Effects of Vitamin D Receptor, Metallothionein 1A, and 2A Gene Polymorphisms on Toxicity of the Peripheral Nervous System in Chronically Lead-Exposed Workers
Authors: Liu Hsin-Liang , Chuang Hung-Yi , Hsu Chien-Ning , Lee Su-Shin , Yang Chen-Cheng , Liu Kuan-Ting
Published: April 2020

Chronic exposure to lead is neurotoxic to the human peripheral sensory system. Variant vitamin D receptor (VDR) genes and polymorphisms of metallothioneins (MTs) are associated with different outcomes following lead toxicity. However, no evidence of a relationship between lead neurotoxicity and polymorphisms has previously been presented. In this study, we investigated the relationship between the polymorphisms of VDR, MT1A, and MT2A genes and lead toxicity following chronic occupational lead exposure. We measured vibration perception thresholds (VPT) and current perception thresholds (CPT) in 181 workers annually for five years. The outcome variables were correlated to the subject’s index of long-term lead exposure. Polymorphisms of VDR, MT1A, and MT2A were defined. The potential confounders, including age, sex, height, smoking, alcohol consumption, and working life span, were also collected and analyzed using linear regression. The regression coefficients of some gene polymorphisms were at least 20 times larger than regression coefficients of time-weighted index of cumulative blood lead (TWICL) measures. All regression coefficients of TWICL increased slightly. MT1A rs11640851 (AA/CC) was associated with a statistically significant difference in all neurological outcomes except hand and foot VPT. MT1A rs8052394 was associated with statistically significant differences in hand and foot CPT 2000 Hz. In MT2A rs10636, those with the C allele showed a greater effect on hand CPT than those with the G allele. Among the VDR gene polymorphisms, the Apa rs7975232 (CC/AA) single nucleotide polymorphism was associated with the greatest difference in hand CPT. MT2A rs28366003 appeared to have a neural protective effect, whereas Apa (rs7975232) of VDR and MT2A rs10636 increased the neurotoxicity as measured by CPT in the hands. MT1A rs8052394 had a protective effect on large myelinated nerves. MT1A rs11640851 was associated with susceptibility to neurotoxicity.
Impact of an Individualized Cognitive Training Intervention in Preschoolers from Poor Homes
Authors: Giovannetti Federico , Pietto Marcos Luis , Segretín María Soledad , Lipina Sebastián Javier
Published: April 2020

Over the last few decades, different interventions were shown to be effective in changing cognitive performance in preschoolers from poor homes undertaking tasks with executive demands. However, this evidence also showed that not all children included in the intervention groups equally increased their performance levels, which could be related to individual and contextual variability. The present study aimed to explore the impact of a computerized cognitive training intervention with lab-based tasks in preschoolers from Unsatisfied Basic Needs (UBN) homes under the consideration of their baseline performance. In the context of a randomized controlled trial design, different interventions were administered to children according to their baseline performance in a variety of cognitive tasks (i.e., executive attention, inhibitory control, working memory, and planning demands). The results showed different patterns of impact on performance depending on the experimental group, supporting the importance of considering individual and contextual differences in the design of interventions aimed at optimizing executive functions in poverty-impacted sample populations in early stages of development.
Continuity of Care Is Associated with Medical Costs and Inpatient Days in Children with Cerebral Palsy
Authors: Yang Kuang-Tsu , Yin Chun-Hao , Hung Yao-Min , Huang Shih-Ju , Lee Ching-Chih , Kuo Tsu-Jen
Published: April 2020

Background: Children with cerebral palsy (CP) place a considerable burden on medical costs and add to an increased number of inpatient days in Taiwan. Continuity of care (COC) has not been investigated in this population thus far. Materials and Methods: We designed a retrospective population-based cohort study using Taiwan’s National Health Insurance Research Database. Patients aged 0 to 18 years with CP catastrophic illness certificates were enrolled. We investigated the association of COC index (COCI) with medical costs and inpatient days. We also investigated the possible clinical characteristics affecting the outcome. Results: Over five years, children with CP with low COCI levels had higher medical costs and more inpatient days than did those with high COCI levels. Younger age at CP diagnosis, more inpatient visits one year before obtaining a catastrophic illness certificate, pneumonia, and nasogastric tube use increased medical expenses and length of hospital stay. Conclusions: Improving COC reduces medical costs and the number of inpatient days in children with CP. Certain characteristics also influence these outcomes.
Incidences of Fatalities on Austrian Ski Slopes: A 10-Year Analysis
Authors: Posch Markus , Schranz Alois , Lener Manfred , Burtscher Martin , Ruedl Gerhard
Published: April 2020

The study evaluated incidences and potential differences of traumatic and nontraumatic fatalities among recreational skiers and snowboarders on Austrian ski slopes within a 10-year analysis. Within this retrospective study, data were collected by the Federal Ministry of the Interior. Data comprised all traumatic and nontraumatic deaths on Austrian ski slopes which occurred between the 2008/09 and 2017/18 winter seasons. Age, sex, nationality, gear used, altitude, slope difficulty, accident cause, primary cause of death and helmet use were collected at the death scene. Incidence of fatalities was calculated based on number of skier days. In total, 369 fatalities, with an average of 36.9 ± 7.9 fatalities per year, were registered. The yearly incidence of traumatic and nontraumatic deaths decreased by 25.8% and 40.1% during the 10-year time period, leading to an evaluated mean incidence of 0.70 deaths per million skier days, with an incidence of 0.36 traumatic deaths and 0.34 nontraumatic deaths per million skier days. Incidences of both traumatic and nontraumatic deaths decreased during the 10-year analysis, representing death as a rare event on Austrian ski slopes. However, adequate prevention measures to reduce potential risk factors to further reduce the mortality risk on ski slopes are needed.
Economic Problems and Loneliness as Factors Related to Subjective Unmet Health Needs in People with Chronic Diseases and Dependency
Authors: López-Entrambasaguas Olga María , Martínez-Linares José Manuel , Sola-García Miguel , García-Redecillas Carmen , Díaz-Meco-Niño Ana María
Published: April 2020

Background: The continuous increase of people with chronic diseases is one of the greatest challenges for healthcare systems worldwide. Population growth and life expectancy means that an increasing number of people with chronic diseases and dependency need some kind of assistance to meet their needs. Determining these subjective unmet needs helps to understand the situation of these people. The aim of this study was to explore the perceptions of chronic patients over 65 years of age from the day-care center toward subjective health needs that are not being met by the socio-health system. Methods: Qualitative exploratory-descriptive study. Through convenience sampling, we selected people with chronic diseases and dependency who used day-care centers and met the inclusion criteria. Focus groups were performed. The data were transcribed and a thematic analysis was carried out using Atlas.ti software. Results: The topics resulting from the analysis were classified into dissatisfaction of biological/physiological needs, psychological needs, social needs, and other issues that arose in both groups of participants which referred to the types of needs previously indicated. The issues related to social and psycho-social needs stood out. Conclusions: People with chronic diseases and dependency have their physiological needs covered with the help they receive, but their situation of dependency generates additional costs that worsen their economic situation. However, their greatest need is due to the loneliness they feel and the feeling they have of “being a burden” on their families.
Indoor Air Pollution, Related Human Diseases, and Recent Trends in the Control and Improvement of Indoor Air Quality
Authors: Tran Vinh Van , Park Duckshin , Lee Young-Chul
Published: April 2020

Indoor air pollution (IAP) is a serious threat to human health, causing millions of deaths each year. A plethora of pollutants can result in IAP; therefore, it is very important to identify their main sources and concentrations and to devise strategies for the control and enhancement of indoor air quality (IAQ). Herein, we provide a critical review and evaluation of the major sources of major pollutant emissions, their health effects, and issues related to IAP-based illnesses, including sick building syndrome (SBS) and building-related illness (BRI). In addition, the strategies and approaches for control and reduction of pollutant concentrations are pointed out, and the recent trends in efforts to resolve and improve IAQ, with their respective advantages and potentials, are summarized. It is predicted that the development of novel materials for sensors, IAQ-monitoring systems, and smart homes is a promising strategy for control and enhancement of IAQ in the future.
Depressive Symptoms, Suicidal Ideation, and Mental Health Service Use of Industrial Workers: Evidence from Vietnam
Authors: Do Ha Ngoc , Nguyen Anh Tuan , Nguyen Hoa Quynh Thi , Bui Thanh Phuong , Nguyen Quy Van , Tran Ngan Thu Thi , Nguyen Long Hoang , Pham Hai Quang , Ha Giang Hai , Hoang Chi Linh , Tran Bach Xuan , Latkin Carl A. , Ho Roger C. M. , Ho Cyrus S. H.
Published: April 2020

Background: Depressive symptoms and suicidal ideation substantially reduce industrial workers’ productivity and performance. This study was performed to examine the prevalence of depressive symptoms and suicidal ideation and identify associated factors among industrial workers in different provinces of Vietnam. Materials and Methods: We performed a cross-sectional study in industrial zones of four provinces of Vietnam. The Patient Health Questionnaire (PHQ-9) was employed to screen depressive symptoms and suicidal ideation. Multivariate logistic regression was performed to determine factors related to depressive symptoms and suicidal ideation. Results: Of 1200 industrial workers, 30.5% and 33.6% industrial workers had positive depressive symptoms and suicidal ideation in the last two weeks, respectively. There were 38.3% ever using mental health services in the last 12 months. High school education (OR = 0.64, 95% CI = 0.44–0.95); living in dormitory (OR = 3.07, 95% CI = 1.51–6.24), living with siblings (OR = 2.98; 95% CI = 1.32–6.75), having two children or more (OR = 1.45, 95% CI = 1.03–2.03), high years of experience (OR = 0.94; 95% CI = 0.89–0.98), suffering from burnout, alcohol use disorder (OR = 2.38; 95% CI = 1.72–3.28), and smoking status (OR = 0.38, 95% CI = 0.23–0.61) were associated with positive depressive symptoms. Living with children, working in mechanical/metallurgy/electronics factories, completely exhausted and often thinking of quitting, and alcohol use disorder were positively related to suicidal ideation. Conclusions: This study found a high prevalence of depressive symptoms and suicidal ideation among industrial workers in Vietnam. Regular screening and detecting high-risk groups, along with interventions to reduce health risk behaviors, burnout and on-site medical service quality improvement, are recommended to alleviate the burden of depression in industrial workers.
Combined Black Rice Germ, Bran Supplement and Exercise Intervention Modulate Aging Biomarkers and Improve Physical Performance and Lower-Body Muscle Strength Parameters in Aging Population
Authors: Seesen Mathuramat , Semmarath Warathit , Yodkeeree Supachai , Sapbamrer Ratana , Ayood Pisittawoot , Malasao Rungnapa , Ongprasert Krongporn , Chittrakul Jiraporn , Siviroj Penprapa , Limtrakul (Dejkriengkraikul) Pornngarm
Published: April 2020

Aging is a time-dependent functional decline in muscle mass and strength, which is reflected in poor physical performances, hormonal imbalance, and development of chronic low-grade inflammation. This study aimed to assess the effectiveness of black rice germ, bran supplement, and exercise program either alone or in combination for 24 weeks on the aging biomarkers (C-reactive protein, Interleukin-6, Insulin-like growth factor-1, and CD4:CD8 T cell ratio) physical performance, muscle strength parameters (walking speed, sit-to-stand time, grip strength) among Thai aging population. A total of 120 healthy volunteers aged 65–74 years were assigned to the exercise group (EX), black rice germ, and bran supplement (BR) group or the combination of BR and EX group (BR + EX). Over the course of the 24-week intervention, compared with baseline data (T0), the combined BR + EX intervention significantly decreased the inflammatory biomarkers (C-reactive protein and interleukin-6 levels, both p < 0.05 vs. T0) and significantly increased the insulin-like growth factor-1 levels (p < 0.001 vs. T0). Significant improvement in physical performance and muscle strength were also observed in the combined BR + EX group (decrease in sit-to-stand time and gait speed over the 24-week intervention, both p < 0.05 vs. T0, and trend toward grip strength improvement at p = 0.088 vs. T0). Overall, our results indicated a synergistic effect towards the combined intervention with the sustainable improvement in physical performances, lower-body muscle strength, and the modulation of both inflammatory and endocrine biomarkers. This study could encourage older adults to change their lifestyles to improve healthy aging and longevity.
Use of Personal Listening Devices and Knowledge/Attitude for Greater Hearing Conservation in College Students: Data Analysis and Regression Model Based on 1009 Respondents
Authors: You Sunghwa , Kwak Chanbeom , Han Woojae
Published: April 2020

Given the concern regarding increased hearing loss in young people who use personal listening devices (PLDs), the present study analyzes the experience of PLDs among college students to identify their knowledge of and attitude toward hearing conservation. It also explains their relationship between knowledge of hearing loss and attitude-related hearing conservation as a questionnaire response using a regression model. A total of 1009 Korean college students responded to an online questionnaire. As a survey tool, the Personal Listening Device and Hearing Questionnaire was adapted as a Korean version with 78 modified items under 9 categories. Using principal component analysis, specific factors were extracted, and their relationships and paths were confirmed using multiple regression analysis. The results of the knowledge category of the questionnaire indicate that most respondents knew how to maintain healthy hearing and understood the signs of hearing loss. Regardless, many college students habitually use PLDs at high levels in noisy environments; they do not recognize how to prevent hearing loss. Even though they continue their current use pattern for PLDs, they also had a positive attitude toward receiving more information about hearing conservation. According to the regression model, the students’ self-reported hearing deficits were due to the volume rather than the frequent use. Interestingly, knowledge about hearing loss may encourage students to develop a positive attitude toward reasonable restriction of PLD use. When PLD users have detailed knowledge about the hearing loss provided by professionals, we believe that most will avoid serious hearing problems and its risks and maintain a judicious attitude toward their own conservation.
Identification and Extraction of Geomorphological Features of Landslides Using Slope Units for Landslide Analysis
Authors: Wang Kai , Xu Hui , Zhang Shaojie , Wei Fangqiang , Xie Wanli
Published: April 2020

A slope unit is commonly used as calculation unit for regional landslide analysis. However, the capacity of the slope unit to reflect the geomorphological features of actual landslides still needs to be verified. This is because such accurate representation is critical to ensure the physical meaning of results from subsequent landslide stability analysis. This paper presents work conducted on landslides and slope extraction in two areas in China: The Jiangjia Gully area (Yunnan Province) and Fengjie County (Chongqing Municipality). Ground-based light detection and ranging (LiDAR) data are combined with field landslide terrace measurements to allow for the comparison of slope unit extraction methods (conventional vs. MIA-HSU) in terms of their ability to reflect the geomorphological features of shallow and deep-seated landslides. The results indicate that slope unit boundaries extracted by the conventional method do not match the geomorphological variations of actual landslides, and the method is therefore deficient in meaningfully extracting slope units for further landslide analysis. By contrast, slope units obtained using the MIA-HSU method accurately reflects the geomorphological features of both shallow and deep-seated landslides, and thus provides clearer geomorphological meaning and more reasonable calculation units for regional landslide assessment and prediction.
Beneficial Effects of Melatonin on Apolipoprotein-E Knockout Mice by Morphological and 18F-FDG PET/CT Assessments
Authors: Nardo Lorenzo , Rezzani Rita , Facchetti Luca , Favero Gaia , Franco Caterina , Abdelhafez Yasser Gaber , Badawi Ramsey Derek , Guindani Michele , Seo Youngho , Pampaloni Miguel
Published: April 2020

Atherosclerosis represents one of the main risk factors for the development of cardiovascular diseases. Their etiologies have been studied in recent years in order to better define therapeutic targets for intervention and to identify diagnostic methods. Two different subtypes of macrophages, M1 and M2, have been described in physiological conditions. They can also be found in the atherosclerotic process, where they both have opposite roles in disease progression. Perivascular brown adipose tissue is also involved in inflammation and endothelial damage. In this work, we provide insights into the protective role of melatonin in the atherosclerotic process by morphological and 18F-FDG-PET/CT analyses. In particular, we examined the effects of melatonin on pathways that are linked to atherosclerosis development. We showed that melatonin, by suppressing M1 activity, reduced inflammation and directed macrophage polarization toward the M2 macrophage subtype. Moreover, melatonin preserved the activity of perivascular brown adipose tissue. In addition, 18F-FDG uptake is very high in mice treated with melatonin, confirming that other factors may alter 18F-FDG distribution. In conclusion, we showed that melatonin affects inflammatory pathways that have been linked to atherosclerosis, assessed the relationships of the 18F-FDG PET/CT parameters with macrophage markers and the production of their cytokines, which that have been defined by morphological evaluations.