bluuebunny/crossref_metadata_2025 huggingface dataset:
Harmonic analysis and statistics of the first Galois cohomology group
Authors: Alberts Brandon , O’Dorney Evan
Published: August 2021

We utilize harmonic analytic tools to count the number of elements of the Galois cohomology group $$f\in H^1(K,T)$$

f
∈

H
1

(
K
,
T
)

with discriminant-like invariant $$\text {inv}(f)\le X$$

inv
(
f
)
≤
X

as $$X\rightarrow \infty $$

X
→
∞

. Specifically, Poisson summation produces a canonical decomposition for the corresponding generating series as a sum of Euler products for a very general counting problem. This type of decomposition is exactly what is needed to compute asymptotic growth rates using a Tauberian theorem. These new techniques allow for the removal of certain obstructions to known results and answer some outstanding questions on the generalized version of Malle’s conjecture for the first Galois cohomology group.
Neutrosophic ratio-type estimators for estimating the population mean
Authors: Tahir Zaigham , Khan Hina , Aslam Muhammad , Shabbir Javid , Mahmood Yasar , Smarandache Florentin
Published: August 2021

All researches, under classical statistics, are based on determinate, crisp data to estimate the mean of the population when auxiliary information is available. Such estimates often are biased. The goal is to find the best estimates for the unknown value of the population mean with minimum mean square error (MSE). The neutrosophic statistics, generalization of classical statistics tackles vague, indeterminate, uncertain information. Thus, for the first time under neutrosophic statistics, to overcome the issues of estimation of the population mean of neutrosophic data, we have developed the neutrosophic ratio-type estimators for estimating the mean of the finite population utilizing auxiliary information. The neutrosophic observation is of the form $${Z}_{N}={Z}_{L}+{Z}_{U}{I}_{N}\, {\rm where}\, {I}_{N}\in \left[{I}_{L}, {I}_{U}\right], {Z}_{N}\in [{Z}_{l}, {Z}_{u}]$$

Z
N

=

Z
L

+

Z
U

I
N

where

I
N

∈

I
L

,

I
U

,

Z
N

∈

[

Z
l

,

Z
u

]

. The proposed estimators are very helpful to compute results when dealing with ambiguous, vague, and neutrosophic-type data. The results of these estimators are not single-valued but provide an interval form in which our population parameter may have more chance to lie. It increases the efficiency of the estimators, since we have an estimated interval that contains the unknown value of the population mean provided a minimum MSE. The efficiency of the proposed neutrosophic ratio-type estimators is also discussed using neutrosophic data of temperature and also by using simulation. A comparison is also conducted to illustrate the usefulness of Neutrosophic Ratio-type estimators over the classical estimators.
Projecting the global impact of fossil fuel production from the Former Soviet Union
Authors: Mohr Steve , Wang Jianliang , Ward James , Giurco Damien
Published: August 2021

Detailed projections of the Former Soviet Union (FSU) fossil fuel production has been created. Russian production has been modelled at the region (oblast) level where possible. The projections were made using the Geologic Resource Supply-Demand Model (GeRS-DeMo). Low, Best Guess and High scenarios were created. FSU fossil fuels are projected to peak between 2027 and 2087 with the range due to spread of Ultimately Recoverable Resources (URR) values used. The Best Guess (BG) scenario anticipates FSU will peak in 2087 with production over 170 EJ per year. The FSU projections were combined with rest of the world projections (Mohr et al. 2015b), the emissions from the High scenario for the world are similar to the IPCC A1 AIM scenario.
High-Defect-Density Graphite for Superior-Performance Aluminum-Ion Batteries with Ultra-Fast Charging and Stable Long Life
Authors: Kim Jisu , Raj Michael Ruby , Lee Gibaek
Published: August 2021

Rechargeable aluminum-ion batteries (AIBs) are a new generation of low-cost and large-scale electrical energy storage systems. However, AIBs suffer from a lack of reliable cathode materials with insufficient intercalation sites, poor ion-conducting channels, and poor diffusion dynamics of large chloroaluminate anions (AlCl4− and Al2Cl7−). To address these issues, surface-modified graphitic carbon materials [i.e., acid-treated expanded graphite (AEG) and base-etched graphite (BEG)] are developed as novel cathode materials for ultra-fast chargeable AIBs. AEG has more turbostratically ordered structure covered with abundant micro- to nano-sized pores on the surface structure and expanded interlayer distance (d002 = 0.3371 nm) realized by surface treatment of pristine graphite with acidic media, which can be accelerated the diffusion dynamics and efficient AlCl4− ions (de)-intercalation kinetics. The AIB system employing AEG exhibits a specific capacity of 88.6 mAh g−1 (4 A g−1) and ~ 80 mAh g−1 at an ultra-high current rate of 10 A g−1 (~ 99.1% over 10,000 cycles). BEG treated with KOH solution possesses the turbostratically disordered structure with high density of defective sites and largely expanded d-spacing (d002 = 0.3384 nm) for attracting and uptaking more AlCl4− ions with relatively shorter penetration depth. Impressively, the AIB system based on the BEG cathode delivers a high specific capacity of 110 mAh g−1 (4 A g−1) and ~ 91 mAh g−1 (~ 99.9% over 10,000 cycles at 10 A g−1). Moreover, the BEG cell has high energy and power densities of 247 Wh kg−1 and 44.5 kW kg−1. This performance is one of the best among the AIB graphitic carbon materials reported for chloroaluminate anions storage performance. This finding provides great significance for the further development of rechargeable AIBs with high energy, high power density, and exceptionally long life.
Comparative Study of Hybrid Artificial Intelligence Approaches for Predicting Peak Shear Strength Along Soil-Geocomposite Drainage Layer Interfaces
Authors: Chao Zhiming , Fowmes Gary , Dassanayake S. M.
Published: August 2021

Peak shear strength of soil-Geocomposite Drain Layer (GDL) interfaces is an important parameter in the designing and operating related engineering structures. In this paper, a database compiled from 316 large direct shear tests on soil-GDL interfaces has been established. Based on this database, five different machine learning models: Back Propagation Artificial Neural Network (BPANN) and Support Vector Machine (SVM), with hyperparameters optimised by Particle Swarm Optimisation Algorithm (PSO) and Genetic Algorithm (GA), respectively, and Extreme Learning Machine (ELM) optimised by Exhaustive Method, were adopt to assess the peak shear strength of soil-GDL interfaces. Then, a comprehensive investigation and comparison of the predictive performance for the models was conducted. Also, based on the selected optimal machine learning model, sensitivity analysis was conducted, and an empirical equation developed based on it. The research indicated that GA and PSO could significantly increase forecasting precision in a small number of iterations. The BPANN model optimised by PSO has the highest forecasting precision based on the statistics criteria: Root-Mean-Square Error, Correlation Coefficient, Coefficient of Determination, Wilmot’s Index of Agreement, and Mean Absolute Percentage Error. The normal stress has the biggest impact on the peak shear strength, followed by drainage core type, moisture saturation of the soil layer, shearing surface, soil type, consolidation condition, geotextile specification, soil density and drainage core thickness, and the ranking is affected partly by the data distribution of input parameters in the database based on mechanism analysis. An empirical equation developed from the optimal model was proposed to estimate the peak shear strength, which provides convenience for geotechnical engineering personnel with limited knowledge of machine learning technique.
Evaluation of Stability of Embankment Constructed on Soft Consolidating Soil with Lime–CFG Composite Column System
Authors: Prakash K. G. , Krishnamoorthy A.
Published: August 2021

Effectiveness of providing lime and CFG composite column system on the safety factor of embankment constructed on consolidating soil is studied at different time intervals during consolidation of foundation soil. The effectiveness of providing composite column system is compared with the effectiveness of providing only lime or CFG columns. In addition, the effectiveness of composite column system on settlement of foundation soil and consolidation process is also investigated. Embankment, foundation soil and columns are modeled using finite element method. Numbers of trial surfaces with different center and radius are generated at each time interval and the critical surface is selected to calculate the safety factor using the effective stresses obtained by finite element analysis. From the study, it is concluded that provision of lime or CFG columns, either individually or in combination, reduces the settlement and improves the safety factor. However, the most effective type of columns and their arrangement to reduce the settlement may not be the most effective to enhance the safety factor and hence, the type of columns and their arrangements has considerable influence on the purpose for which columns are provided.
Effect of Ibrutinib on Hmphocytic Leukemia
Authors: Hassan Hamza , Ud Din Mohammad Ammad , Jamshed Saad , Bress Jonathan , Mustafa S Shahzad
Published: August 2021

Objective/Background:

In the era of novel agents, Bruton tyrosine kinase (BTK) inhibitors have changed the dynamics of treating chronic lymphocytic leukemia. However, small studies have shown conflicting results regarding the additive humoral dysfunction with their use.

Methods:

We prospectively compared vaccine responses in patients on ibrutinib (n = 10) with matched controls (n = 16) and analyzed whether a protein-based (tetanus-diphtheria toxoid) or a carbohydrate (Pneumovax) moiety will result in an improved immunological response.

Results:

An appropriate serological response in IgG titers for diphtheria was seen in 40% of patients on ibrutinib and 31% of patients in the control group. About 30% of patients on ibrutinib and 44% of patients in the control group had an adequate response to tetanus toxoid. None of the patients on ibrutinib mounted an adequate response to Pneumovax, while 31% of patients in the control arm responded appropriately. These differences in the results were considered insignificant as all p values were greater than the cut-off of 0.05.

Conclusion:

Our study did not show significant detrimental vaccine responses with ibrutinib and calls for larger multicenter studies to elucidate long-term effects, especially in patients with prior exposure to anti-CD20 monoclonal antibodies.
Developing and evaluating a team development intervention to support interdisciplinary teams
Authors: Morgan Susan E. , Mosser Alexandra , Ahn Soyeon , Harrison Tyler R. , Wang Jue , Huang Qian , Reynolds Ashley , Mao Bingjing , Bixby John L.
Published: August 2021

Introduction:

Incentivizing the development of interdisciplinary scientific teams to address significant societal challenges usually takes the form of pilot funding. However, while pilot funding is likely necessary, it is not sufficient for successful collaborations. Interdisciplinary collaborations are enhanced when team members acquire competencies that support team success.

Methods:

We evaluated the impact of a multifaceted team development intervention that included an eight-session workshop spanning two half-days. The workshop employed multiple methods for team development, including lectures on empirically supported best practices, skills-based modules, role plays, hands-on planning sessions, and social interaction within and across teams. We evaluated the impact of the intervention by (1) asking participants to assess each of the workshop sessions and (2) by completing a pre/postquestionnaire that included variables such as readiness to collaborate, goal clarity, process clarity, role ambiguity, and behavioral trust.

Results:

The content of the team development intervention was very well received, particularly the workshop session focused on psychological safety. Comparison of survey scores before and after the team development intervention indicated that scores on readiness to collaborate and behavioral trust were significantly higher among participants who attended the workshop. Goal clarity, process clarity, and role ambiguity did not differ among those who attended versus those who did not.

Conclusions:

Multicomponent team development interventions that focus on key competencies required for interdisciplinary teams can support attitudes and cognitions that the literature on the science of team science indicate are predictive of success. We offer recommendations for the design of future interventions.
Evaluation of Factors Related to the Survival of Hospitalized Patients With COVID-19: Survival Analysis With Frailty Approach
Authors: Sarbakhsh Parvin , Ghaffary Saba , Shaseb Elnaz
Published: August 2021

Objective:

Considering that coronavirus disease 2019 (COVID-19) is an emerging disease and results in very different outcomes, from complete recovery to death, it is important to determine the factors affecting the survival of patients. Given the lack of knowledge about effective factors and the existence of differences in the outcome of individuals with similar values of the observed covariates, this study aimed to investigate the factors affecting the survival of patients with COVID-19 by the parametric survival model with the frailty approach.

Methods:

The data of 139 patients with COVID-19 hospitalized in Imam Reza Hospital in Tabriz were analyzed by the Gompertz survival model with gamma frailty effect. At first, variables with P < 0.1 in univariable analysis were included in the multivariable analysis, and then the stepwise method was used for variable selection.

Results:

Diabetes mellitus was significantly related to the survival of hospitalized patients (P = 0.021). The rest of the investigated variables were not significant. The frailty effect was significant (P = 0.019).

Conclusions:

In the investigated sample of patients with COVID-19, diabetes was an important variable related to patient survival. Also, the significant frailty effect indicates the existence of unobserved heterogeneity that causes individuals with a similar value of the observed covariates to have different survival distributions.
Geodesic stretch, pressure metric and marked length spectrum rigidity
Authors: GUILLARMOU COLIN , KNIEPER GERHARD , LEFEUVRE THIBAULT
Published: August 2021

We refine the recent local rigidity result for the marked length spectrum obtained by the first and third author in [GL19] and give an alternative proof using the geodesic stretch between two Anosov flows and some uniform estimate on the variance appearing in the central limit theorem for Anosov geodesic flows. In turn, we also introduce a new pressure metric on the space of isometry classes, which reduces to the Weil–Petersson metric in the case of Teichmüller space and is related to the works [BCLS15, MM08].
Mental health needs of the COVID-19 patients and staff in the Fangcang shelter hospital: a qualitative research in Wuhan, China
Authors: Lu Jing , Zhao Min , Wu Qianying , Ma Chenyi , Du Xiangdong , Lu Xinchuan , Jia Qiufang , Li Chuanwei
Published: August 2021

Background

During the coronavirus disease 2019 (COVID-19) pandemic, Fangcang shelter hospitals were opened in Wuhan, China, to isolate and care for patients with mild or moderate symptoms. The patients and staff in the hospitals faced mental health challenges. This paper reports the experiences and mental health needs from them.

Method

Following the qualitative design, semi-structured interviews were conducted in the EastWest Lake Fangcang Shelter Hospital, Wuhan on March 2020. Data collection and analysis was based on grounded theory. Open coding was adapted and a structured codebook was developed through coding seminars. The themes and subthemes were then confirmed through thematic analysis. The findings were further explained and integrated in a theoretical framework.

Results

A total of 10 COVID-19 patients and 13 staff, including doctors, nurses, psychiatrists, and policemen participated in the interviews. They have common needs, as well as their own needs. The perspectives from the staff also did complement for needs of the patients. The mental health needs were generalized into four themes, that is, basic needs, information and communication, emotional needs, and social support, each with several subthemes. In addition, there were some external factors that regulated the internal needs, which were summarized in a theoretical framework.

Conclusions

The study indicates the directions on hospital management, mental health services, policy making, and social work to meet the mental health needs of the inpatients and staff from temporary shelter hospitals like Fangcang in Wuhan during the COVID-19 pandemic.
Hegel's Later Theory of Cognition: An Additive or Transformative Model?
Authors: Corti Luca
Published: August 2021

This article investigates Hegel's later theory of perception and cognition, identifying and analysing its general assumptions about the relation among the mind's activities. These often unremarked upon assumptions, I claim, continue to underwrite recent interpretive controversies. I demonstrate how a correct understanding of such assumptions points us toward an alternative interpretation of Hegel's model of the mind. I argue that this new model changes how we understand (a) Hegel's later notion of ‘non-conceptual content’ and (b) his distinction between human and animal minds—two areas that constitute the fault line dividing interpretations of late Hegel. To isolate the relevant assumptions, I use Matthew Boyle's influential conceptual distinction between ‘additive’ and ‘transformative’ models of rationality. I demonstrate that Hegel himself addresses the basic issues characterizing this distinction and clarify how approaching his work in these terms presents considerable interpretative and conceptual advantages, including allowing us to defend the position that Hegel adopts a ‘transformative’ framework of mind. To support this argument, this paper closely analyses Hegel's treatment of sensation (Empfindung), which has not yet been systematically addressed by scholars. I show how sensation can be best understood as part of Hegel's later ‘transformative’ framework for cognition. I also show how this framework can be extended to other parts of Hegel's theory.
Surface ablation and its drivers along a west–east transect of the Southern Patagonia Icefield
Authors: Bravo Claudio , Ross Andrew N. , Quincey Duncan J. , Cisternas Sebastián , Rivera Andrés
Published: August 2021

Glaciers in the Southern Patagonia Icefield (SPI) have been shrinking in recent decades, but due to a lack of field observations, understanding of the drivers of ablation is limited. We present a distributed surface energy balance model, forced with meteorological observations from a west–east transect located in the north of the SPI. Between October 2015 and June 2016, humid and warm on-glacier conditions prevailed on the western side compared to dry and cold conditions on the eastern side. Controls of ablation differ along the transect, although at glacier-wide scale sensible heat (mean of 72 W m−2 to the west and 51 W m−2 to the east) and net shortwave radiation (mean of 54 W m−2 to the west and 52 W m−2 to the east) provided the main energy sources. Net longwave radiation was an energy sink, while latent heat was the most spatially variable flux, being an energy sink in the east (−4 W m−2) and a source in the west (20 W m−2). Ablation was high, but at comparable elevations, it was greater to the west. These results provide new insights into the spatial variability of energy-balance fluxes and their control over the ablation of Patagonian glaciers.
A late Cisuralian (early Permian) brachiopod fauna from the Taungnyo Group in the Zwekabin Range, eastern Myanmar and its biostratigraphic, paleobiogeographic, and tectonic implications
Authors: Xu Hai-peng , Aung Kyi Pyar , Zhang Yi-chun , Shi G.R. , Cai Fu-long , Zaw Than , Ding Lin , Sein Kyaing , Shen Shu-zhong
Published: August 2021

The tectonic evolution of the Sibumasu Block during the Permian remains controversial, and Permian faunas and their paleobiogeographic affinities provide some insight into its paleogeographic and tectonic evolutionary histories. In this paper, a new brachiopod fauna dominated bySpinomartinia prolificaWaterhouse, 1981 is described from the uppermost part of the Taungnyo Group in the Zwekabin Range, eastern Myanmar. This brachiopod fauna includes 23 species and its age is well constrained as late Kungurian by the associated conodonts, i.e.,Vjalovognathus nicolliYuan et al., 2016 andMesogondolella idahoensis(Youngquist, Hawley, and Miller, 1951), contrary to the late Sakmarian age given to the same brachiopod faunas previously reported from southern Thailand and Malaysia. Based on comprehensive comparisons of the Cisuralian brachiopod faunas and other data in different parts of the Sibumasu Block, we consider that they are better subdivided into two independent stratigraphic assemblages, i.e., the lower (earlier)Bandoproductus monticulus-Spirelytha petaliformisAssemblage of a Sakmarian to probably early Artinskian age, and the upper (younger)Spinomartinia prolifica-Retimarginifera alataAssemblage of a late Kungurian age. The former assemblage is a typical cold-water fauna, mainly composed of Gondwanan-type genera, e.g.,BandoproductusJin and Sun, 1981,SpirelythaFredericks, 1924, andSulciplicaWaterhouse, 1968. The latter assemblage is strongly characterized by an admixture of both Cathaysian and Gondwanan elements, as well as some genera restricted to the Cimmerian continents. Notably, the spatial distribution pattern of these two separate brachiopod assemblages varies distinctly. The Sakmarian cold-water brachiopod faunas have been found in association with glacial-marine diamictites throughout the Sibumasu Block including both the Irrawaddy and Sibuma blocks. In contrast, the Kungurian biogeographically mixed brachiopod faunas are only recorded in the Irrawaddy Block, unlike the Sibuma Block that contains a contemporaneous paleotropical Tethyan fusuline fauna. Thus, it appears likely that by the end of Cisuralian (early Permian), the Sibumasu Block comprised the Irrawaddy Block in the south with cool climatic conditions, and the Sibuma Block in the north with a temperate to warm-water environment, separated by the incipient Thai-Myanmar Mesotethys.
The PSYchiatric clinical outcome prediction (PSYCOP) cohort: leveraging the potential of electronic health records in the treatment of mental disorders
Authors: Hansen Lasse , Enevoldsen Kenneth C. , Bernstorff Martin , Nielbo Kristoffer L. , Danielsen Andreas A. , Østergaard Søren D.
Published: August 2021

Background:

The quality of life and lifespan are greatly reduced among individuals with mental illness. To improve prognosis, the nascent field of precision psychiatry aims to provide personalised predictions for the course of illness and response to treatment. Unfortunately, the results of precision psychiatry studies are rarely externally validated, almost never implemented in clinical practice, and tend to focus on a few selected outcomes. To overcome these challenges, we have established the PSYchiatric Clinical Outcome Prediction (PSYCOP) cohort, which will form the basis for extensive studies in the upcoming years.

Methods:

PSYCOP is a retrospective cohort study that includes all patients with at least one contact with the psychiatric services of the Central Denmark Region in the period from January 1, 2011, to October 28, 2020 (n= 119 291). All data from the electronic health records (EHR) are included, spanning diagnoses, information on treatments, clinical notes, discharge summaries, laboratory tests, etc. Based on these data, machine learning methods will be used to make prediction models for a range of clinical outcomes, such as diagnostic shifts, treatment response, medical comorbidity, and premature mortality, with an explicit focus on clinical feasibility and implementation.

Discussions:

We expect that studies based on the PSYCOP cohort will advance the field of precision psychiatry through the use of state-of-the-art machine learning methods on a large and representative data set. Implementation of prediction models in clinical psychiatry will likely improve treatment and, hopefully, increase the quality of life and lifespan of those with mental illness.
The Post-Soviet City as a Communal Apartment: Spatialized Belonging in Ulan-Ude
Authors: Jonutytė Kristina
Published: August 2021

This article explores diversity, belonging and representation in the city of Ulan-Ude, Buryatia (Russian Federation). In particular, it looks at their discourses and practices as they take spatial forms in the fast-changing post-Soviet urban environment. Through case studies of two central locations in the city – a statue of Lenin and a Buddhist prayer wheel – the article reveals recent tendencies of “indigenization” (Szmyt 2014) in Ulan-Ude’s material and discoursive space, exploring them as instances that would suggest an image of a “contested city” (Low 1996). However, this article aims at complicating the latter concept, demonstrating that seeming contestations should be read in their particular context, taking into consideration local ideas and practices of accommodating diversity.
Global motion planning and redundancy resolution for large objects manipulation by dual redundant robots with closed kinematics
Authors: Wu Yongxiang , Fu Yili , Wang Shuguo
Published: August 2021

The multi-arm robotic systems consisting of redundant robots are able to conduct more complex and coordinated tasks, such as manipulating large or heavy objects. The challenges of the motion planning and control for such systems mainly arise from the closed-chain constraint and redundancy resolution problem. The closed-chain constraint reduces the configuration space to lower-dimensional subsets, making it difficult for sampling feasible configurations and planning path connecting them. A global motion planner is proposed in this paper for the closed-chain systems, and motions in different disconnected manifolds are efficiently bridged by two type regrasping moves. The regrasping moves are automatically chosen by the planner based on cost-saving principle, which greatly improve the success rate and efficiency. Furthermore, to obtain the optional inverse kinematic solutions satisfying joint physical limits (e.g., joint position, velocity, acceleration limits) in the planning, the redundancy resolution problem for dual redundant robots is converted into a unified quadratic programming problem based on the combination of two diff erent-level optimizing criteria, i.e. the minimization velocity norm (MVN) and infinity norm torque-minimization (INTM). The Dual-MVN-INTM scheme guarantees smooth velocity, acceleration profiles, and zero final velocity at the end of motion. Finally, the planning results of three complex closed-chain manipulation task using two Franka Emika Panda robots and two Kinova Jaco2 robots in both simulation and experiment demonstrate the effectiveness and efficiency of the proposed method.
Design of a variable stiffness index finger exoskeleton
Authors: Attal Abhishek , Dutta Ashish
Published: August 2021

This paper presents the design and experimentation of a variable stiffness index finger exoskeleton consisting of four-bar mechanisms actuated by a linear actuator. The lengths of the four-bar mechanism were optimized so that it can follow a recorded index fingertip trajectory. The mechanism has a fixed compliance at the coupler of the four-bar link and a variable compliance at the linear actuator that moves the four-bar. The skeletal shape of the coupler of the finger link has been optimized using FEM. The exoskeleton can apply a constant fingertip force irrespective of the position of the fingers.
Variation in quality of maternal input and development of coda stops in English-speaking children in Singapore
Authors: SIM Jasper Hong , POST Brechtje
Published: August 2021

This study examines the effects of input quality on early phonological acquisition by investigating whether interadult variation in specific phonetic properties in the input is reflected in the production of their children. We analysed the English coda stop release patterns in the spontaneous speech of fourteen mothers and compared them with the spontaneous production of their preschool children. The analysis revealed a very strong positive input–production relationship; mothers who released coda stops to a lesser degree also had children who tended to not release their stops, and the same was true for mothers who released their stops to a higher degree. The findings suggest that young children are sensitive to acoustic properties that are subphonemic, and these properties are also reflected in their production, showing the importance of considering input quality when investigating child production.
Current perspectives on global sugar consumption: definitions, recommendations, population intakes, challenges and future direction
Authors: Walton Janette , Bell Haley , Re Roberta , Nugent Anne P
Published: August 2021

Currently, there is considerable emphasis on the relationship between dietary sugar consumption and various health outcomes, with some countries and regions implementing national sugar reduction campaigns. This has resulted in significant efforts to quantify dietary sugar intakes, to agree on terms to describe dietary sugars and to establish associated recommendations. However, this information is infrequently collated on a global basis and in a regularised manner. The present review provides context regarding sugar definitions and recommendations. It provides a global review of the available data regarding dietary sugar intake, considering forms such as total, free and added sugars. A comprehensive breakdown of intakes is provided by age group, country and sugar form. This analysis shows that free sugar intakes as a percentage of total energy (%E) are the highest for children and adolescents (12–14%E) and the lowest for older adults (8%E). This trend across lifecycle stages has also been observed for added sugars. The available data also suggest that, while some reductions in sugar intake are observed in a few individual studies, overall intakes of free/added sugars remain above recommendations. However, any wider conclusions are hampered by a lack of detailed high-quality data on sugar intake, especially in developing countries. Furthermore, there is a need for harmonisation of terms describing sugars (ideally driven by public health objectives) and for collaborative efforts to ensure that the most up-to-date food composition data are used to underpin recommendations and any estimates of intake or modelling scenarios.
Adolescents’ neural reactivity to acute psychosocial stress: dysfunctional regulation habits are linked to temporal gyrus response
Authors: Golde Sabrina , Gleich Tobias , Romund Lydia , Stippl Anna , Pelz Patricia , Raufelder Diana , Lorenz Robert C. , Beck Anne
Published: August 2021

Mid-adolescence is a critical time for the development of stress-related disorders and it is associated with significant social vulnerability. However, little is known about normative neural processes accompanying psychosocial stress at this time. Previous research found that emotion regulation strategies critically influence the relationship between stress and the development of psychiatric symptoms during adolescence. Using functional magnetic resonance imaging (fMRI), we examined neural responses to acute stress and analyzed whether the tendency to use adaptive or maladaptive emotion regulation strategies is related to neural and autonomic stress responses. Results show large linear activation increases from low to medium to high stress levels mainly in medial prefrontal, insulae and temporal areas. Caudate and subgenual anterior cingulate cortex, neural areas related to reward and affective valuations, showed linearly decreasing activation. In line with our hypothesis, the current adolescent neural stress profile resembled social rejection and was characterized by pronounced activation in insula, angular and temporal cortices. Moreover, results point to an intriguing role of the anterior temporal gyrus. Stress-related activity in the anterior temporal gyrus was positively related to maladaptive regulation strategies and stress-induced autonomic activity. Maladaptive coping might increase the social threat and reappraisal load of a stressor, relating to higher stress sensitivity of anterior temporal cortices.
Compositional matrix-space models of language: Definitions, properties, and learning methods
Authors: Asaadi Shima , Giesbrecht Eugenie , Rudolph Sebastian
Published: August 2021

We give an in-depth account of compositional matrix-space models (CMSMs), a type of generic models for natural language, wherein compositionality is realized via matrix multiplication. We argue for the structural plausibility of this model and show that it is able to cover and combine various common compositional natural language processing approaches. Then, we consider efficient task-specific learning methods for training CMSMs and evaluate their performance in compositionality prediction and sentiment analysis.
Health behaviours as predictors of the Mediterranean diet adherence: a decision tree approach
Authors: Bôto Joana Margarida , Marreiros Ana , Diogo Patrícia , Pinto Ezequiel , Mateus Maria Palma
Published: August 2021

Objective:

This study aimed to identify health behaviours that determine adolescent’s adherence to the Mediterranean diet (MD) through a decision tree statistical approach.

Design:

Cross-sectional study, with data collected through a self-fulfilment questionnaire with five sections: (1) eating habits; (2) adherence to the MD (KIDMED index); (3) physical activity; (4) health habits and (5) socio-demographic characteristics. Anthropometric and blood pressure data were collected by a trained research team. The Automatic Chi-square Interaction Detection (CHAID) method was used to identify health behaviours that contribute to a better adherence to the MD.

Setting:

Eight public secondary schools, in Algarve, Portugal.

Participants:

Adolescents with ages between 15 and 19 years (n325).

Results:

According to the KIDMED index, we found a low adherence to MD in 9·0 % of the participants, an intermediate adherence in 45·5 % and a high adherence in 45·5 %. Participants that regularly have breakfast, eat vegetable soup, have a second piece of fruit/d, eat fresh or cooked vegetables 1 or more times a day, eat oleaginous fruits at least 2 to 3 times a week, and practice sports and leisure physical activities outside school show higher adherence to the MD (P< 0·001).

Conclusions:

The daily intake of two pieces of fruit and vegetables proved to be a determinant health behaviour for high adherence to MD. Strategies to promote the intake of these foods among adolescents must be developed and implemented.
Effects of Transition to Water‐Efficient Solutions on Existing Centralized Sewer Systems—An Integrated Biophysical Modeling Approach
Authors: Penn Roni , Maurer Max
Published: August 2021

Technical alternatives offering high water efficiency are being developed to complement existing centralized water and wastewater conveyance and treatment systems. Understanding of the negative effects wide‐spread implementation of such alternative systems may have on existing systems is still limited, despite the importance of this inevitable transition. In this study, we present a novel approach to systematically identify these negative impacts. A comprehensive model integrating transport and transformation processes in sewer pipes was set up and simulated for various transition scenarios. A significant finding of this research is that reduced flows and increased chemical oxygen demand (COD) concentrations result in the accumulation of sediments and sulphides in sewer pipes. For the examined sewer system, when reducing the total daily flow by 50%, 30% of the pipes were found to accumulate sediments, and 30% of the pipes experienced effects due to the presence of sulphides in different states depending on the wastewater temperature. It was found that an optimal spatial distribution of these water‐efficient solutions will most likely require compromises between sediment and sulphide accumulation. The product of two design parameters, diameter and bed slope, was found to be a suitable predictor of the potential of a pipe to accumulate sediments. This research provides novel approaches to assessing the feasibility of transition to solutions offering higher water efficiency. The results indicate where the most affected points in the systems are expected to occur and might help in preparing an experimental approach to assess such negative effects, increasing urban water management efficiency.
Projected Changes to Hydroclimate Seasonality in the Continental United States
Authors: Marvel Kate , Cook Benjamin I. , Bonfils Céline , Smerdon Jason E. , Williams A. Park , Liu Haibo
Published: August 2021

Future changes to the hydrological cycle are projected in a warming world, and any shifts in drought risk may prove extremely consequential for natural and human systems. In addition to long‐term moistening, drying, or warming trends, perturbations to the annual cycle of regional hydroclimate variables may also have substantial impacts. We analyze projected changes in several hydroclimate variables across the continental United States, along with shifts in the amplitude and phase of their annual cycles. We find that even in regions where no robust change in the annual mean is expected, coherent changes to the annual cycle are projected. In particular, we identify robust regional phase shifts toward earlier arrival of peak evaporation in the northern regions, and peak runoff and total soil moisture in the western regions. Changes in the amplitude of the annual cycle of total and surface soil moisture are also projected, and reflect changes to the annual cycle in surface water supply and demand. Whether changes become detectable above the background noise of internal variability depends strongly on the future scenario considered, and significant changes to the annual cycle are largely avoided in the lowest‐forcing scenario.
An Arctic Strait of Two Halves: The Changing Dynamics of Nutrient Uptake and Limitation Across the Fram Strait
Authors: Tuerena Robyn E. , Hopkins Jo , Buchanan Pearse J. , Ganeshram Raja S. , Norman Louisa , von Appen Wilken‐Jon , Tagliabue Alessandro , Doncila Antonia , Graeve Martin , Ludwichowski Kai U. , Dodd Paul A. , de la Vega Camille , Salter Ian , Mahaffey Claire
Published: August 2021

The hydrography of the Arctic Seas is being altered by ongoing climate change, with knock‐on effects to nutrient dynamics and primary production. As the major pathway of exchange between the Arctic and the Atlantic, the Fram Strait hosts two distinct water masses in the upper water column, northward flowing warm and saline Atlantic Waters in the east, and southward flowing cold and fresh Polar Surface Water in the west. Here, we assess how physical processes control nutrient dynamics in the Fram Strait using nitrogen isotope data collected during 2016 and 2018. In Atlantic Waters, a weakly stratified water column and a shallow nitracline reduce nitrogen limitation. To the west, in Polar Surface Water, nitrogen limitation is greater because stronger stratification inhibits nutrient resupply from deeper water and lateral nitrate supply from central Arctic waters is low. A historical hindcast simulation of ocean biogeochemistry from 1970 to 2019 corroborates these findings and highlights a strong link between nitrate supply to Atlantic Waters and the depth of winter mixing, which shoaled during the simulation in response to a local reduction in sea‐ice formation. Overall, we find that while the eastern Fram Strait currently experiences seasonal nutrient replenishment and high primary production, the loss of winter sea ice and continued atmospheric warming has the potential to inhibit deep winter mixing and limit primary production in the future.
Advancing the Evidence for Yoga as a Promising Quality of Life Intervention in Pediatric Populations With Chronic Illness: A Call to Action
Authors: Schaefer Megan R. , Frye William S.
Published: August 2021

Objective: Treatment plans for youth with chronic illness are often solely focused on illness symptomatology, resulting in missed opportunities to address other components of the chronic illness experience. Because yoga incorporates physical activity and meditation, this practice has the potential to improve physical and psychosocial health while improving overall quality of life. Thus, this topical review (a) briefly summarizes preliminary evidence for the impact of yoga on quality of life in pediatric populations with chronic medical conditions, (b) evaluates the current feasibility and acceptability of yoga interventions, (c) describes limitations of current research, and (d) provides an agenda for future research and clinical directions. Method: Topical review. Results: The current literature on yoga interventions in pediatric populations with chronic medical conditions is limited by methodological issues, impacting the interpretability of findings. While more rigorous methodology is needed, preliminary findings suggest promise for the feasibility and acceptability of yoga interventions. Further, the current data indicates practicing yoga may positively impact quality of life outcomes in pediatric populations with chronic illness. Conclusion: Yoga interventions may have the potential to improve quality of life in youth with chronic medical conditions. However, further research is warranted to advance the literature and determine whether yoga is an efficacious and effective treatment for pediatric populations with chronic illness.

Implications for Impact Statement

Beyond addressing illness symptoms, yoga may have the potential to improve overall quality of life in youth with chronic illness, highlighting the importance of integrative medicine. Currently, methodological rigor is limited in this area; thus, future studies involving randomized controlled trials (RCTs) and standardized yoga intervention protocols are needed to advance this line of research.
FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity
Authors: Mysore Vijayashree , Cullere Xavier , Mears Joseph , Rosetti Florencia , Okubo Koshu , Liew Pei X. , Zhang Fan , Madera-Salcedo Iris , Rosenbauer Frank , Stone Richard M. , Aster Jon C. , von Andrian Ulrich H. , Lichtman Andrew H. , Raychaudhuri Soumya , Mayadas Tanya N.
Published: August 2021

Classical dendritic cells (cDC) are professional antigen-presenting cells (APC) that regulate immunity and tolerance. Neutrophil-derived cells with properties of DCs (nAPC) are observed in human diseases and after culture of neutrophils with cytokines. Here we show that FcγR-mediated endocytosis of antibody-antigen complexes or an anti-FcγRIIIB-antigen conjugate converts neutrophils into nAPCs that, in contrast to those generated with cytokines alone, activate T cells to levels observed with cDCs and elicit CD8+ T cell-dependent anti-tumor immunity in mice. Single cell transcript analyses and validation studies implicate the transcription factor PU.1 in neutrophil to nAPC conversion. In humans, blood nAPC frequency in lupus patients correlates with disease. Moreover, anti-FcγRIIIB-antigen conjugate treatment induces nAPCs that can activate autologous T cells when using neutrophils from individuals with myeloid neoplasms that harbor neoantigens or those vaccinated against bacterial toxins. Thus, anti-FcγRIIIB-antigen conjugate-induced conversion of neutrophils to immunogenic nAPCs may represent a possible immunotherapy for cancer and infectious diseases.
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Authors: Vichas Athea , Riley Amanda K. , Nkinsi Naomi T. , Kamlapurkar Shriya , Parrish Phoebe C. R. , Lo April , Duke Fujiko , Chen Jennifer , Fung Iris , Watson Jacqueline , Rees Matthew , Gabel Austin M. , Thomas James D. , Bradley Robert K. , Lee John K. , Hatch Emily M. , Baine Marina K. , Rekhtman Natasha , Ladanyi Marc , Piccioni Federica , Berger Alice H.
Published: August 2021

CRISPR-based cancer dependency maps are accelerating advances in cancer precision medicine, but adequate functional maps are limited to the most common oncogenes. To identify opportunities for therapeutic intervention in other rarer subsets of cancer, we investigate the oncogene-specific dependencies conferred by the lung cancer oncogene, RIT1. Here, genome-wide CRISPR screening in KRAS, EGFR, and RIT1-mutant isogenic lung cancer cells identifies shared and unique vulnerabilities of each oncogene. Combining this genetic data with small-molecule sensitivity profiling, we identify a unique vulnerability of RIT1-mutant cells to loss of spindle assembly checkpoint regulators. Oncogenic RIT1M90I weakens the spindle assembly checkpoint and perturbs mitotic timing, resulting in sensitivity to Aurora A inhibition. In addition, we observe synergy between mutant RIT1 and activation of YAP1 in multiple models and frequent nuclear overexpression of YAP1 in human primary RIT1-mutant lung tumors. These results provide a genome-wide atlas of oncogenic RIT1 functional interactions and identify components of the RAS pathway, spindle assembly checkpoint, and Hippo/YAP1 network as candidate therapeutic targets in RIT1-mutant lung cancer.
An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism
Authors: Ptacin Jerod L. , Caffaro Carolina E. , Ma Lina , San Jose Gall Kristine M. , Aerni Hans R. , Acuff Nicole V. , Herman Rob W. , Pavlova Yelena , Pena Michael J. , Chen David B. , Koriazova Lilia K. , Shawver Laura K. , Joseph Ingrid B. , Milla Marcos E.
Published: August 2021

The implementation of applied engineering principles to create synthetic biological systems promises to revolutionize medicine, but application of fundamentally redesigned organisms has thus far not impacted practical drug development. Here we utilize an engineered microbial organism with a six-letter semi-synthetic DNA code to generate a library of site-specific, click chemistry compatible amino acid substitutions in the human cytokine IL-2. Targeted covalent modification of IL-2 variants with PEG polymers and screening identifies compounds with distinct IL-2 receptor specificities and improved pharmacological properties. One variant, termed THOR-707, selectively engages the IL-2 receptor beta/gamma complex without engagement of the IL-2 receptor alpha. In mice, administration of THOR-707 results in large-scale activation and amplification of CD8+T cells and NK cells, without Treg expansion characteristic of IL-2. In syngeneic B16-F10 tumor-bearing mice, THOR-707 enhances drug accumulation in the tumor tissue, stimulates tumor-infiltrating CD8+T and NK cells, and leads to a dose-dependent reduction of tumor growth. These results support further characterization of the immune modulatory, anti-tumor properties of THOR-707 and represent a fundamental advance in the application of synthetic biology to medicine, leveraging engineered semi-synthetic organisms as cellular factories to facilitate discovery and production of differentiated classes of chemically modified biologics.