bluuebunny/crossref_metadata_2025 huggingface dataset:
THE RESPONSE OF BULLS ORGANISM TO NON-SPECIFIC STIMULATORS OF RESISTANCE AND THE FORMATION OF IMMUNE-BIOLOGICAL REACTIVITY
Authors: Velichko V. O.
Published: December 2024

The intense man-made load on agro-ecosystems causes a negative impact on the physiological, clinical, productive state of animals and has a negative effect as a stress factor on the body's immune system. The conducted studies confirm that man-made loads on the animal body, as well as the use of non-specific stimulants of resistance, exacerbate the problem of regulating disorders of the immune system. The factors causing a decrease in the immune status, as well as the resistance of the animal body, include: industrial technology of animal breeding, chemicalization in crop production, man-made pressure, imbalance of the diet in terms of nutrients and biologically active substances. The very mechanism of the development of the body's reaction to non-specific factors of resistance formation, i.e. immuno-biological reactivity, is closely related to the activity of POL (lipid peroxidation) and the depression of the antioxidant potential. Under these conditions, the ability of the body to mobilize protective and adaptive capabilities in response to the action of both negative factors in general and nonspecific stimulators of resistance acquires special importance (Chumachenko & Pavlenko, 2004; Velychko, 2008, 2011).
Under the conditions of the impact of man-made load and non-specific stimulators of resistance on the animal body, effective and already confirmed practice is the use of effective, proven methods of regulating the activity of the enzymatic system of antioxidant protection with the use of biologically active substances, in particular trace elements and vitamins. The results of the conducted research confirm that this has a positive effect on the formation of the immunobiological reactivity of the animal body and significantly reduces the influence of non-specific stimulants of resistance. And this is an opportunity to directly (aggressively) influence the formation of productive and adaptive properties of animals, which is important for the quality and safety of products of animal origin.
Therefore, knowledge of the laws of the formation of the body's resistance, correspondingly its immune-biological reactivity, is important in the development of methods for the correction of the immunodeficiency state, antioxidant protection.
BIOCHEMICAL AND MORPHOLOGICAL BLOOD PARAMETERS OF LIMOUSIN BREED COWS OF DIFFERENT SELECTIONS
Authors: Zelinka M. P. , Fedorovych Ye. I. , Mazur N. P. , Orikhivsky T. V.
Published: December 2024

Improving breeds to increase the productivity and breeding qualities of animals is impossible without a comprehensive study of the physiological and biochemical processes occurring in a living organism. Blood plays an important role in maintaining the body's vital functions. The level of metabolism depends on the quantitative and qualitative indicators of blood, and this serves as the main criterion for assessing the physiological state of animals.
 In view of the above, the aim of this study was to examine the morphological and biochemical blood parameters of cows imported from Poland and Hungary, as well as those of domestic breeding. The research was conducted at Lvivske LLC, Lviv region, on cows of the Limousin breed of Hungarian, Polish and Ukrainian selection.
 It was found that the biochemical and morphological blood parameters of Limousin cows varied to some extent according to country of origin. In particular, cows of Ukrainian breeding showed a higher concentration of hemoglobin, total protein, globulins and their fractions, red blood cells, and lymphocytes compared to animals of Polish and Hungarian breeding. The highest levels of leukocytes, monocytes, and granulocytes were observed in Polish-bred animals. Regarding albumin content, no significant difference was observed between animals of Polish and Ukrainian breeding; however, Hungarian-bred cows exhibited slightly lower albumin levels compared to their counterparts in the other two groups, though they had a relatively higher content of albumin and globulins. The lowest levels of globulin fractions were observed in Polish-bred cows, which may indicate both unique individual characteristics and a reduced level of adaptation to new environmental conditions. The highest albumin-globulin ratio observed in Hungarian-bred cows indicates an increased albumin content relative to globulins, often seen in cases of inadequate immune response or decreased globulin (antibody) synthesis, potentially signaling reduced immune protection and adaptability to stress factors.
Among imported Limousin cows, ALT and AST activities were higher compared to those of domestic breeding. This may be attributed to stress due to changes in housing conditions, transportation, or feeding practices. Elevated enzyme activity generally indicates increased protein metabolism, reflecting the body’s response to meet heightened energy and resource demands required for stress adaptation.
RESEARCH OF THE ACTIVITY OF DISINFECTANTS TO MICROORGANISMS ISOLATED FROM PATHOLOGICAL POULTRY MATERIAL
Authors: Kushnir I. М. , Berbeka U. Z. , Gufriy D. F. , Kolodiy H. V. , Murska S. D. , Semen I. S. , Kushnir V. I.
Published: December 2024

Disinfectants should have low toxicity and allergenicity, have good solubility in water or easily form suspensions, emulsions in it, act quickly and in small concentrations, be sufficiently stable during storage and environmentally safe.
An important characteristic of each disinfectant should also be a wide spectrum of antimicrobial action on microorganisms. Therefore, the sensitivity of strains of microorganisms isolated from pathological poultry material to disinfectants was studied. During the identification of cultures isolated from the pathological material of poultry, six isolates of Essherichia coli and three isolates of Salmonella enteritidis were isolated.
Four disinfectants were used for the study, which included alkyldimethylbenzylammonium chloride and glutaraldehyde (sample №1), didecyldimethylammonium bromide (sample №2), polyhexamethylenebiguanidine hydrochloride (sample №3), and peracetic acid (sample № 4).
It was established that out of six isolates E. coli isolated from the pathological material, one was resistant to the disinfectant based on polyhexamethylenebiguanidine hydrochloride, which was 16,7 % and out of three S. enteritidis isolates, two isolates were 66,7 %.
Three out of six E. coli isolates were resistant to the disinfectant based on peracetic acid, which was 50 %, and one isolate was resistant out of three S. enteritidis isolates, which was 33,3 %.
VETERINARY HOMEOPATHY AS AN ADDITIONAL TOOL IN THE TREATMENT OF PETS
Authors: Lisova N. , Pyatnychko O. , Shkodyak N. , Sobodosh O. , Maksymovych O.
Published: December 2024

The use of homeopathy for the treatment of diseases and maintenance of animal health is a promising, but not yet sufficiently elucidated method of therapy. The advantage of homeopathic medicines is their safety, the absence of side effects and the danger of drug overdose. However, according to the beliefs of most veterinary specialists, they should be used in combination with traditional medicine methods and responsibly, since treatment with homeopathic medicines involves an individual approach to the animal. According to this statement, homeopathy is primarily suitable for treatment of pets, as it involves a detailed examination and questioning of the owner about symptoms and previous experiences. That is why studies on the use of known or newly created homeopathic preparations continues and enriches theoretical and practical veterinary medicine with new scientific data.
This article provides examples of the use of the homeopathic remedy Berberis-Homacord (solution for injection) in the complex therapy of diseases in cats accompanied by signs of damage to the genitourinary and digestive body’s systems. Changes in the animal’s condition during the experiment were assessed by a veterinarian based on the clinical indicators of the sick animals – behavior, reaction to the environment, body temperature, appetite, condition of the mucous membranes, frequency and rhythm of respiratory movements, and heartbeat. The safety of the drug was assessed by analyzing the results of laboratory tests - determining the blood morphological parameters and biochemical parameters of the blood serum before using the drug in comparison with the data obtained after its use. The results of cats’s hematological and biochemical blood tests after treatment with the drug Berberis-Homacord as part of complex therapy indicated a gradual return of the animals' parameters to the limits of the reference interval.
According to changes of the general clinical indicators of the animal's body, obtained data from laboratory tests and observations of veterinary medicine specialists, the use of the drug Berberis-Homacord as part of complex therapy for cats in the treatment of diseases contributes to the faster normalization of the body's condition indicators.
SIMULTANEOUS DETERMINATION OF COCCIDIOSTATICS IN FEEDS AND PREMIXES USING HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY
Authors: Melikyan S. , Mysko G. , Biront N. , Yanovych D.
Published: December 2024

Coccidiostats – ionophore polyester antibiotics (monensin sodium, lasalocid sodium, salinomycin sodium, narazin, maduramycin ammonium and others) have a wide spectrum of action. Coccidiostats are used for the treatment and prevention of eimeriosis in target animals. They are added to the feed in the appropriate dosage. They are used to increase the efficiency of growth and development of farm animals and poultry also. Production of such feeds and premixes requires strict control of possible processes of cross-contamination with other coccidiostats, safety and quality.
Salinomycin sodium, monensin sodium, narazin and maduramycin ammonium in feed and premix samples were determined by high-performance thin-layer chromatography (HPTLC). The separation is carried out due to the dissolution of the investigated substances in the mobile phase and is based on adsorption, distribution, ion exchange and the combination of these processes in the stationary phase. This technique proved to be a sufficiently specific and economically advantageous express method for the determination of coccidiostats. In addition, analyzed substances are determined simultaneously by the method of high-performance thin-layer chromatography, up to 17 samples can be analyzed on one plate under the same conditions. This is important for optimizing working time in the laboratory and efficient use of consumables. Two-dimensional separation mixture standard samples of coccidiostats was carried out to check the stability of the analytes in the stationary phase on the plate. The limit of detection of the studied analytes by the HPTLC method was 3.0 mg/kg.
Were analyzed 199 feed samples and 266 premix samples of monensin sodium, salinomycin sodium, narasin and maduramycin ammonium content from 2015 to 2024 years. The samples were sent to National Reference Laboratory of Veterinary Drug Residues Control for the State Registration of Veterinary Drug, Feed Additives and for Contractual Subjects.
Therefore, the coccidiostats detection and determination of their content in feed and premixes for the control of processes cross-contamination with other coccidiostats, for safety and for quality remains relevant in the future and will continue.
STUDY OF ACUTE AND SUB-ACUTE TOXICITY OF A PREPARATION BASED ON SULFADIMIDINE AND TRIMETHOPRIM
Authors: Patereha I. , Kushnir V. , Pyatnychko O. , Vynarchuk-Paterega V. , Yurynec T. , Chudyak M. , Martynyk S.
Published: December 2024

In Ukraine, the market of veterinary drugs is saturated with a large number of preparations of various purposes, a significant share of which is occupied by sulfonamides. The combination of sulfanilamide (sulfadimidine) and trimethoprim provides an opportunity to manifest the drug to exhibit a bactericidal effect. At the same time, the appearance of strains of microorganisms resistant to the action of the drug is insignificant. At the same time, the use of medicinal products with several active substances in veterinary practice requires careful study of the toxicity of complex preparations.
The parameters of the acute toxicity of the preparation "Riketron N" were studied on white rats, 2-3 months old, weighing 180-200 g. The preparation was administered intramuscularly, once. To determine the toxicity of the preparation "Riketron N" for white rats, doses of 1000, 2500 and 5000 mg/kg of the animal's body weight were taken. Six laboratory animals were used for each dose.
Subacute toxicity was studied on 18 white rats weighing 180-200 g. For this purpose, according to the principle of analogues, a control and two experimental groups of animals, 6 rats in each, were formed. The preparation was administered intramuscularly. Animals of the control group were injected with water for injections. The animals of the 1st experimental group were administered the preparation "Riketron N" in a therapeutic dose of 0,03 ml per animal; the animals of the 2nd experimental group received the preparation in a 5-fold therapeutic dose of 0,15 ml per animal. In a subacute experiment, the preparation "Riketron N" was administered to rats for 10 days.
Under the conditions of intramuscular administration of the preparation "Riketron N", the DL50 for white rats is 1583 mg/kg of body weight. The use of the drug "Riketron N" in therapeutic and 5-fold therapeutic doses for 10 days leads to liver and kidney damage in all experimental animals.
STUDY OF THE MINIMUM BACTERICIDAL CONCENTRATION OF POLYHEXAMETHYLENEGUANIDINE, SILVER PREPARATIONS AND DIMEXIDE ON TEST-CULTURES OF MICROORGANISMS
Authors: Romazan I. V.
Published: December 2024

Modern, highly efficient animal husbandry technologies provide for their significant accumulation in a limited area. In addition, this increases the requirements for choosing high-quality, environmentally friendly means for disinfection. In this regard, highly effective and safe drugs are polyhexamethyleneguanidine, silver drugs and dimexide, the composition of which can be an effective disinfectant in the future. That is why the work aimed to establish the minimum bactericidal concentration of polyhexamethyleneguanidine, colloidal silver, silver nanoaquachelates and dimexide on test cultures of microorganisms S. aureus, E. coli, B. subtilis, C. albicans. Microbiological studies on the determination of the minimal bactericidal effect of the test substances were carried out in two stages: by well and suspension methods following the methodological recommendations "Study of the specific activity of antimicrobial drugs" (Volyansky et al., 2004) and "Determination of the bactericidal activity and control of the absence of bacteriostatic effect of disinfectants" (Kovalenko, 2019). At the first stage of the study, it was established that a 0.1 % solution of silver nanoaquachelate has a higher bactericidal effect on test cultures of S. aureus, E. coli, B. subtilis, compared to a 10 % solution of colloidal silver. The results of the second stage of research showed that polyhexamethyleneguanidine and silver nanoaquachelates have bactericidal activity on test cultures of microorganisms S. aureus, E. coli, C. albicans in very low concentrations, namely: no growth of S. aureus was observed even at a concentration of polyhexamethyleneguanidine of 0, 00625 % for 20 min and 0.003125 % during 40 min, E. coli at concentrations of 0.003125 % and 0.001562%, respectively, and C. albicans regardless of the time regime at concentrations of 0.00625 %. The bactericidal effect of silver nanoaquachelates against S. aureus was manifested at a concentration of 0.005 % for 20 minutes. and 0.0025 % for 40 min, E. coli at concentrations of 0.0025 % and 0.00125 %, respectively, and C. albicans regardless of exposure time at concentrations of 0.0025 %. The effectiveness of dimexide concerning the specified test cultures of the studied microorganisms was observed at a much higher concentration at 0.4 % concerning S. aureus regardless of the time of action, E. coli at a concentration of 0.3 % for 20 minutes, respectively. action and 0.2 % within 40 min actions, and C. albicans regardless of exposure time at a concentration of 0.3 %.
CHANGES IN PHYSIOLOGICAL INDICATORS IN DOGS WITH GASTROENTERITIS
Authors: Slyusar N. V.
Published: December 2024

The work is devoted to the study of the local and general influence of inflammatory processes in the gastrointestinal tract on the general condition and functionality of physiological processes in dogs of different age, gender and breed groups. The negative role of pathogenic and other factors causing inflammation of the stomach and intestine in dogs is highlighted. Among the diseases of non-infectious etiology in carnivores, and in particular in dogs, lesions of the digestive system are still, unfortunately, often found.
Symptoms characterizing existing inflammatory processes of the digestive system can have both non-infectious and infectious etiology.
However, in some cases, there is an increased reactivity of the body to these stimuli of the receptor apparatus of the mucous membrane of the canal, in others - a slight violation of the course of physiological processes is registered only with the help of laboratory studies of biological material and, in particular, primarily blood, urine, gastric juice, feces. Almost 50 percent of diseases of non-infectious etiology are gastritis, enteritis, colitis and gastroenterocolitis.
There are many works on this topic in the scientific literature, but mainly research is conducted on the effectiveness of pharmacotherapy with drugs of one or another pharmacological group. During the study of this problem, it turned out that inflammation of the gastrointestinal tract in dogs is caused, quite often, by violations of the feeding regime, drinking, traumatizing the mucous membrane with traumatic objects such as fish bones, chickens, as well as exercise disorders.
All these factors can in different ways disturb the general physiological state of the animal and cause pathological symptoms.
During the research period, when working with animals, attention was paid to keeping, breeding and using animals in accordance with their physiological needs in accordance with the Law of Ukraine "On the Protection of Animals from Cruelty".
APPLICATION OF ELISA AND HPLC-MS/MS METHODS IN CLINICAL TRIALS OF VETERINARY DRUGS FOR THE DETERMINATON OF IVERMECTIN CONTENT
Authors: Yanovych D. , Zasadna Z. , Rydchuk M. , Plotytsia S. , Kislova S. , Pazderska O. , Korol N. , Trach Y.
Published: December 2024

The article presents the results of the development and validation of screening method and chromatographic mass spectrometric method for the determining of ivermectin residual amounts in muscles and parenchymal tissues of pigs and calves, as well as in blood plasma, for clinical trials (for withdrawal period establishing and bioequivalence study of drugs based on ivermectin).
EuroProxima Ivermectin test kits (Netherlands) were used to determine ivermectin residues in animal tissues. When carrying out the validation at the levels of ½ MRL, which is 15 and 30 μg/kg for muscle and parenchymal tissues, the LOD for the analyte was established at the levels of 2.7 and 4.1 μg/kg, respectively. To establish the percent of analyte’s recovery from the spiked samples, selected blank samples and samples, spiked with ivermectin solution at ½ MRL and MRL levels, were prepared and analyzed according to the technique provided by the test kit manufacturer. The percentage of analyte’s recovery for muscle tissues spiked at the level of 15.0, 30.0, 100.0 μg/kg was: 100.2, 100.4, 99.9, respectively. For liver tissues, spiked at the level of 50.0, 100.0, 500.0 μg/kg, it was 100.0, 99.95, 99.5, respectively.
To establish the bioequivalence of veterinary drugs based on ivermectin, we have developed and validated high-performance liquid chromatography with tandem mass spectrometric detection (HPLC-MS/MS) method. The suggested method of sample preparation includes the liquid-liquid extraction of the analyte with ethyl acetate from an acidic medium and concentration by drying. Analysis of the prepared samples was performed by HPLC-MS/MS (analyte’s retention time 2.64 min, mass scanning parameters: precursor ion 892.8 m/z, product ions 307.2 and 569.4 m/z). Various key parameters were used to validate the chromatographic technique: limit of detection, limit of quantification, working and linear concentration ranges, accuracy, and precision. The results of the performed validation are presented in the article in tables and chromatograms, and conclusions about the fitness-for-purpose of the method are also made.
Realidade e perspectivas do mercado de trabalho em educação física para o século XXI
Authors: Nascimento Juarez Vieira do
Published: December 2024

O presente estudo analisa as realidades e perspectivas do mercado de trabalho em Educação Física no século XXI. O objetivo é explorar a diversidade de áreas de atuação, as características do mercado e as projeções futuras para os profissionais da área. Observou-se que a atuação vai além do ensino formal, abrangendo setores como lazer, saúde, turismo e administração esportiva. Entre os resultados, destacam-se a crescente demanda por profissionais em novos mercados e a necessidade de atualização contínua para acompanhar as mudanças econômicas e sociais. Conclui-se que o sucesso dos profissionais dependerá de sua capacidade de adaptação, inovação e gerenciamento de suas carreiras em um cenário marcado pela competição e pela diversificação.
Obesidade: uma alteração física indesejada
Authors: Aguiar Iolanda Emília de
Published: December 2024

O objetivo deste artigo, é realizar uma reflexão junto aos leitores quanto aos hábitos alimentares inadequados e principalmente a falta de desenvolver atividade física regularmente. A obesidade é atualmente um dos males da sociedade desenvolvida e este, inicia-se na infância, onde herdamos uma formação errônea da nossa alimentação e, consequentemente, com o abandono do movimento no desenvolvimento das atividades do nosso dia-a-dia, tendo em vista a tecnologia do momento, acabamos sendo vítimas deste mal.
Propostas para o ensino da educação física
Authors: Brandl Neto Inácio
Published: December 2024

Neste texto procuro mostrar propostas de ensino/aprendizagem para a Educação Física. Vários autores apresentam suas idéias devidamente embasadas. Neste estudo, reporto-me a cinco propostas, com determinadas características que as diferenciam. Algumas são aplicadas na prática, porém, boa parte só existe "no papel" ou são pouco utilizadas. Neste trabalho apresento as seguintes propostas: a Tradicional, a Desenvolvimentista, a Construtivista, a Crítico-Superadora e a Crítico-Emancipadora. A Educação Motora é outra proposta atual. Escreverei a respeito dela em outro texto.
Musculação relacionada à performance competitiva do judoca paranaense
Authors: Hobold Edilson , Moreira Vitor Cesar
Published: December 2024

Este estudo teve como objetivo avaliar a relação entre o treinamento com pesos e o desempenho competitivo de judocas do sexo masculino do Paraná. A amostra foi composta por 40 atletas, divididos em dois grupos: 20 praticantes de musculação e 20 não praticantes. Os dados foram coletados durante os Campeonatos Paranaenses e os Jogos Abertos do Paraná entre 1994 e 1997. Foram aplicados questionários e analisados os resultados das competições oficiais. O estudo revelou que os judocas que praticavam musculação obtiveram melhores resultados competitivos em comparação com os não praticantes. Os resultados sugerem que o treinamento com pesos influencia positivamente o desempenho atlético, particularmente quando equilibrado com sessões de treinamento específicas para judô.
"Educa-Ação" física: uma abordagem curricular na formação de profissionais
Authors: Peres Luís Sérgio
Published: December 2024

Este estudo teve como objetivo refletir sobre a formação e estruturação dos currículos dos cursos de Educação Física no Brasil, destacando a necessidade de uma abordagem que vá além da técnica e do esporte como fins exclusivos, considerando aspectos sociais, culturais e humanos. O trabalho aborda a crise na educação brasileira, caracterizada por desafios como a desvalorização dos professores, a baixa qualidade do ensino e a fragmentação do currículo. Destaca-se a necessidade de repensar a docência, aproximando-a de uma perspectiva crítica e transformadora. Discute-se a importância de um currículo que integre teoria e prática, além de enfatizar o desenvolvimento de competências investigativas, críticas e sociais nos futuros profissionais de Educação Física. O estudo também alerta para os problemas de uma formação tecnicista e propõe a inclusão de práticas pedagógicas comprometidas com a realidade social e cultural. A Educação Física no Brasil necessita de uma reformulação curricular que contemple a formação integral dos profissionais, promovendo uma educação voltada para a transformação social, o bem-estar e a qualidade de vida. O texto reforça a urgência de mudanças estruturais que alinhem o curso às demandas contemporâneas e incentivem a reflexão sobre a prática docente.
Analisis Penyebab APU Auto Shutdown pada Pesawat Airbus A 320
Authors: Ginti Firdaus Angga
Published: December 2024

berlokasi di area unpressurized pada tail cone pesawat. Fungsi dari APU (Auxiliary Power Unit) adalah agar pesawat mendapatkan electrical system serta pneumatic system saat pengoperasian pesawat di darat maupun di udara dengan batasan pengoperasian tertentu sesuai jenis atau tipe APU tersebut. APU Auto Shutdown adalah kondisi dimana APU mengalami malfunction pada saat beroperasi ataupun pada saat starting, yang menyebabkan APU menjadi berhenti beroperasi secara otomatis untuk mencegah kerusakan pada sistem yang lain. Berdasarkan hasil dari PFR (Post Flight Report) dan dari bite test APU Auto Shutdown Report di CFDS, ada beberapa message yang berbeda-beda yang menyebabkan APU Auto Shutdown dan cara mengatasi masalah tersebut. Beberapa metode yang digunakan seperti studi literature melalui AMM (Aircraft Maintenance Manual), observasi di lapangan, dan konsultasi ke Engineer Specialist Engine dan APU, untuk menganalisa masalah APU Auto Shutdown dengan menggunakan diagram Fish Bone. Berdasarkan hasil analisis mengenai penyebab APU Auto Shutdown pada pesawat Airbus A320, dapat disimpulkan bahwa masalah penyebab APU Auto Shutdown dengan Fault Message FCU (8022KM) / APU FUEL SUPPLY / STARTER MOTOR (8KA) banyak diakibatkan karena adanya kerusakan pada Starter Motor yang terjadi karena akibat dari banyaknya pengoperasian APU. Berdasarkan cara perbaikan masalah APU Auto Shutdown dengan Fault Message FCU (8022KM) / APU FUEL SUPPLY / STARTER MOTOR (8KA) yang terjadi pada APU, yaitu dengan mengganti APU STARTER MOTOR (8KA). Setelah itu melakukan operational test pada APU, untuk memastikan APU beroperasi dengan normal dan tidak terjadi lagi auto shutdown.
Kajian Proses Pembuatan Suku Cadang Molding Pada Industri Elektronik
Authors: Irawan Benny Haddli , Hakim Rahman , Laili Nurul , Saputra Ihsan , Baharudin Budi , Maskarai Abulija
Published: December 2024

Penelitian ini dilakukan berdasarkan hasil survei dan investigasi pada industri elektronik yang berlokasi di Bintan. Perusahaan tersebut bergerak pada bidang Design and Manufacture of Precision Engineering Plastic Components and Electronic Connectors. Dari hasil konsolidasi diperoleh bahwa salah satu aktivitas yang dilakukan yaitu melakukan proses maintenance dengan cara melakukan penggantian suku cadang Molding yang digunakan untuk menghasilkan komponen plastik maupun elektronik. Pada aktivitas produksi, suku cadang Molding tersebut secara prosedur pasti dilakukan pergantian setiap jumlah produksi tertentu atau bisa diperkirakan setiap bulannya terjadi pergantian suku cadang. Oleh karenanya menjaga kesediaan suku cadang menjadi hal yang urgen demi terlaksananya proses produksi dan terpenuhi target perusahaan. Suku cadang yang dimaksud selama ini dipesan dan dibuat dari negara Singapura sehingga perputaran, proses transfer maupun kajian teknologi tidak termanfaatkan oleh industri di Indonesia. Padahal nilai suku cadang yang diganti setiap bulannya sangat besar dengan perkiraan secara kasar memiliki nilai total milyaran rupiah. Berdasarkan hal tersebut diperlukan kajian yang berfokus untuk mendalami proses pembuatan suku cadang dari Molding sehingga industri tidak perlu mengimpor suku cadang dari negara luar.
Synthesis and characterization of methyl methacrylate - glycerol hydrogels by polymerization in acid medium
Authors: Trujillo-Vargas Laura
Published: December 2024

Hydrogels were prepared from methyl methacrylate, glycerol, and sulfuric or citric acid. A novel route for the synthesis of crosslinked materials using unconventional initiators was evaluated using a 23 factorial experimental design. Effects of independent variables (polymerization time, type, and acid concentration) were statistically analyzed through ANOVA. The synthesis route includes condensation, free-radical and transesterification reactions with modifications of the polymer chemical properties such as the formation of a crosslinking polyester with polymethylmethacrylate (PMMA) and improvement of the mechanical and thermal properties of the hydrogel. A polymerization time of 4-hour produced the highest amount of material when 1.37 g sulfuric acid was used and 3.46 g when citric acid was added. The polymer synthesized with citric acid has a swelling rate up to 214.6%, compared with the materials produced with sulfuric acid that reach up to 31.3% of water absorption.
Experimental Study of a Brackish Water Desalination Plant
Authors: Asif Ifrah , Hammad Baig Mirza , Hasnain Sohail , Ahmed Sadia
Published: December 2024

Water desalination is crucial for addressing global water scarcity affecting over 2 billion people. By 2050, water demand could rise by 20-30% due to population growth and urbanization. Currently, over 40% of the global population lacks access to clean water due to overexploitation of conventional sources like rivers and groundwater. This report focuses on experimental analysis of brackish water desalination, primarily using reverse osmosis (RO). Desalination plays a vital role in converting seawater or brackish water into drinkable water, especially in coastal areas. The study explores various desalination methods such as ion exchange, membrane distillation, and vapor compression distillation. Technological advancements, particularly in RO distillation process has enhanced efficiency and sustainability. In this report, pre-treatment processes, including filtration, chemical dosing, antiscalant injection, water softening, are also employed to remove contaminants before desalination. The performance of RO is evaluated based on factors like pressure drop, feed flow rate, and recovery ratio, analyzing water flux, salt rejection rate, energy consumption, and system efficiency. The results provide insights into optimizing brackish water desalination and the discussions are carried out for improvement of the ways such as post treatment, membrane cleaning and advancement in membrane materials for sustainable freshwater production.
NSTEMI and Ischemic Mitral Regurgitation: Incidence and Long-Term Clinical Outcomes with Respect to Management Strategy
Authors: Vyas Pooja , Dake Radhakishan , Kanabar Kewal , Patel Iva , Mishra Ashish , Sharma Vishal , Nathwani Tirth , Parwani Kunal , Rathod Mital
Published: December 2024

Abstract Background The optimal treatment for ischemic mitral regurgitation (IMR) in patients of non-ST elevation myocardial infarction (NSTEMI) is a debated topic. Objective To evaluate the long term outcome on patients with NSTEMI and IMR, particularly emphasizing the comparison of treatments in those with moderate to severe MR. Methods We enrolled patients with NSTEMI and classified non/trivial to mild regurgitation as insignificant IMR and moderate to severe regurgitation as significant IMR. Furthermore, patients with substantial IMR were assessed for long-term clinical outcomes with respect to different management strategies. A test was considered statistically significant based on the probability value p<0.05. Results From a total of 4,189 patients of NSTEMI, significant IMR was found in 7.21% of patients. A significantly higher number of patients with death (1.21% vs. 13.24%, p<0.0001), cardiogenic shock (0.46% vs. 13.24%, p<0.0001) and heart failure (1.03% vs. 11.59%, p<0.0001) were found during hospitalization in patients with significant IMR. At a 2-year follow-up, a higher event rate was observed in the significant IMR group. Patients with significant IMR re-vascularized either by percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), or CABG+ mitral valve (MV) surgery showed substantial improvement in MR grade ( 32.65% vs. 6% vs. 16.98%, p<0.0001) and LVEF (27.55% vs. 1% vs. 1.89%, p<0.0001) at 1 year follow up and significantly improved outcomes were identified compared to refused revascularization and medical management group with (-5.10% vs. 15% vs. 13.21%, p=0.04) mortality, (-33.67% vs. 61% vs. 73.58%, p<0.0001) readmission, and (-15.31% vs. 27% vs. 33.96%, p=0.01) heart failure at 2 years follow up. Conclusion Higher mortality and admission rates were observed in patients with significant IMR compared to those with in-significant IMR. Notably, significant IMR patients who underwent PCI, CABG, or CABG+MV surgery showed improved outcomes compared to non-revascularized counterparts.
Atividade Anti-Inflamatória In Vivo do D-Limoneno em um Modelo de Hipertensão Pulmonar Induzida por Monocrotalina em Ratos: Implicações à Função Cardíaca
Authors: Teixeira-Fonseca Jorge Lucas , Orts Diego Jose Belato y , Silva Polyana Leal da , Conceição Michael Ramon de Lima , Hermes Hernan , Prudencio Carlos R. , Roman-Campos Danilo
Published: December 2024

Resumo Fundamento O D-Limoneno (D-L) é o principal monoterpeno monocíclico com propriedades anti-inflamatórias encontrado em plantas citrus. A Hipertensão pulmonar (HP) pode causar disfunção cardíaca direita e aumentar o risco de morte, em parte devido à resposta inflamatória no coração. Objetivo Avaliar o possível efeito protetor do D-L sobre a função cardíaca em um modelo de HP induzida por Monocrotalina (MCT) (HP-MCT) em ratos. Métodos Monitoramento eletrocardiográfico in vivo. A técnica de coloração tricromo de Masson foi empregada para verificar fibrose no coração. A função de contratilidade do tecido atrial foi estudada usando o banho de órgãos isolados. O PCR quantitativo em tempo real foi aplicado para quantificar inflamação no ventrículo direito. Resultados O grupo HP-MCT mostrou remodelamento estrutural e elétrico do coração, com a presença de fibrose no tecido cardíaco e alterações eletrocardiográficas in vivo. O tratamento com D-L preveniu em parte o desenvolvimento de fibrose tecidual e o aumento na duração da onda P no grupo HP-MCT. As velocidades de contração e de relaxamento do átrio direito e do átrio esquerdo isolado foram aceleradas nos animais CTR e HP-MCT tratados com D-L. Finalmente, o D-L foi capaz de prevenir a expressão anormal das citocinas inflamatórias chave, interleucina 1-β, interleucina 6 e fator de necrose tumoral α, no ventrículo direito dos animais do modelo HP-MCT. D-L foi capaz de aumentar a produção da citocina anti-inflamatória interleucina-10. Conclusão Nossos resultados mostraram que a administração in vivo de D-L preveniu em parte o remodelamento molecular, estrutural e funcional do coração no modelo HP-MCT com atenuação da reposta inflamatória no coração.
O Papel do Treinamento Físico na Melhoria da Qualidade de Vida para Cardiopatia Congênita Adulta: Revisão Sistemática
Authors: Siyah Tugba , Yagli Naciye Vardar , Ertugrul Ilker , Aykan Hayrettin Hakan , Saglam Melda
Published: December 2024

Resumo Fundamento As diretrizes atuais orientam a prática de exercícios para a maioria dos pacientes com cardiopatia congênita (CPC). No entanto, a atividade física continua baixa em indivíduos com CPC, com pesquisas limitadas sobre os efeitos dos exercícios em adultos. Objetivos O objetivo deste estudo é avaliar a segurança e a eficácia do treinamento físico sobre a capacidade de realização do exercício e a qualidade de vida para pacientes com cardiopatia congênita adulta (CPCA). Métodos Pesquisamos as bases de dado da PubMed/Medline, Cochrane Library, Web of Science e Scopus até dezembro de 2022 em busca de estudos clínicos randomizados que avaliassem os efeitos do treinamento aeróbico e de resistência sobre a capacidade de realização de exercícios e a qualidade de vida na CPCA. Das 3.517 citações obtidas, dez artigos elegíveis foram incluídos. Resultados A metanálise dos estudos clínicos randomizados incluídos (286 participantes) não revelou mudanças significativas no consumo de máximo de oxigênio ou na qualidade de vida na CPCA com treinamento com exercícios (diferença média combinada = 0,33 ml/kg/min [IC de 95%, -0,88 a 1,54 ml/kg/min]; p = 0,60; I2 = 3%). No entanto, o aumento na carga de trabalho máxima foi significativo (diferença média combinada = 8,86 watts [IC de 95%, 0,78 a 16,93], p = 0,03, I2 = 0%). Conclusões Nossa revisão confirma que o treinamento com exercícios aumenta a carga de trabalho máxima em pacientes com CPCA. No entanto, a falta de um protocolo padronizado entre as intervenções de exercícios nessa população pode ter contribuído para a ausência de uma mudança significativa no pico de VO2 e na qualidade de vida observada nos estudos conduzidos. Além disso, a heterogeneidade dos programas de exercícios pode ser um fator contribuinte para a inconsistência dos resultados. Neste contexto, a implementação de protocolos de exercícios padronizados em pesquisas futuras, particularmente com tamanhos de amostra maiores, é fundamental para melhorar a comparabilidade dos resultados. Estudos clínicos randomizados bem projetados, que avaliem o treinamento com exercícios estruturados em pacientes com CPCA, fornecerão dados mais claros.
The Role of Ethics in the Professional Activity of a Higher School Teacher
Authors:   Central Russian Institute of Management – Branch of RANEPA, Turkova E. V.
Published: December 2024

The article examines the role of professional ethics of a higher school teacher, stipu-lated by to the priority of the principle of modern education humanization. The basic teach-ers’ behavior requirements are highlighted. The necessity to form a worthy personal brand of a teacher in a digital environment is noted.
Mediatization as an Attempt to Individualize Learning Process
Authors:   Oryol State Agrarian University, Bondareva N. A. , Zamurueva N. A. ,   Central Russian Institute of Management – Branch of RANEPA
Published: December 2024

Changes connected with mass media have far-reaching social consequences for people's social relations, for the formation of identity and world view, as well as for econom-ic reproduction. This development, including its social and cultural consequences, is now called "mediatization". The authors of the article try to describe the action fields and social worlds in which social actions and cultural development of the sense are inextricably linked with the media. This refers to all levels of social development. Mediatization can be analyti-cally understood as a metaprocess of social changs, since, strictly speaking, it has neither a beginning nor a direction. In this regard, the focus of the analysis is on changes as such and the phenomena related to them.
Tactical and Technical Training of Basketball Players of 15-16 years old
Authors:   Central Russian Institute of Management – Branch of RANEPA, Grinin A.V. , Soroka V.V. ,   Central Russian Institute of Management – Branch of RANEPA
Published: December 2024

Sports games are an important part of physical education and development of ado-lescents. They contribute to formation of collective spirit, development of physical and men-tal abilities, as well as improvement of overall physical fitness. Basketball is one of the most popular team games among teenagers.
Análise das ações de vigilância epidemiológica da COVID-19 no Brasil: um estudo de revisão
Authors: Nayara Paiva Dantas Marianny , Araújo Rocha Mayara , Porto Alves Jairo , Simone Galvão Pinto Erika , Lima de Souza Nilba , Assis Neves Dantas Rodrigo , Maria de Medeiros Soraya , Sami Albuquerque de Oliveira Jonas
Published: December 2024

Introdução: Os serviços de Vigilância Epidemiológica foram fundamentais no enfrentamento da COVID-19, entretanto, diversos fatores estiveram como entraves na atuação deste seguimento da saúde pública no Brasil. Deste modo, este estudo busca evidenciar as lições aprendidas. Objetivo: analisar ações dos serviços de vigilância epidemiológica durante a pandemia da COVID-19 no Brasil.
Objetivo:  Analisar ações dos serviços vigilância epidemiológica para o enfrentamento da pandemia da COVID-19 no Brasil, representadas pelo uso das ferramentas SWOT e 5W2H.
Método: Revisão integrativa realizada em cinco etapas, com coleta de dados em dezembro de 2021, mediante a busca de publicações elegíveis em bases de dados. Os dados foram tabulados e analisados de forma descritiva, através das ferramentas (SW2H) What (o que deve ser feito?), Why (por que deve ser feito?), Where (onde deve ser feito?), When (quando deve ser feito?), Who (por quem deve ser feito?), How (como deve ser feito?), How much (quanto irá custar?) e a matriz (SWOT) Strengths (Forças), Weaknesses (Fraquezas), Opportunities (Oportunidades) e Threats (Ameaças).
Resultados: As ações descritas nos estudos são provenientes das vigilâncias municipais, estaduais, Ministério da Saúde e núcleo de vigilância epidemiológica de serviços de saúde, os quais, articulados a órgãos da saúde e de outras áreas buscaram o enfrentamento da pandemia e redução de seus efeitos à saúde pública. Houve fragilidades na articulação com as demais vigilâncias em saúde e atenção primária a saúde. Utilizou-se recursos para melhoria de processos e estrutura do Sistema Único de Saúde.
Conclusão: As ações de enfrentamento da pandemia pelas vigilâncias epidemiológicas envolveram diversos setores da sociedade, tiveram impacto individual e coletivo. Fragilidades e ameaças inerentes as entidades envolvidas e à crise sanitária, apresentaram-se como desafios à vigilância epidemiológica, porém, destaca-se sua relevância para a redução do impacto da COVID-19 no cenário brasileiro.
DILEMMAS AND RELIEF STRATEGIES FOR RURAL TEACHERS' PROFESSIONAL DEVELOPMENT
Authors: Duan Ran
Published: December 2024

This paper examines the professional development dilemmas faced by rural teachers in the context of high-quality rural education development and proposes solutions. It analyzes the challenges rural teachers face in professional identity, professional competence, and local knowledge, while suggesting solutions including enhancing professional identity, building professional learning communities, strengthening internal motivation, and implementing targeted training programs. These aims to promote rural teachers' professional growth and advance high-quality development of rural education.
KEYWORDS: Rural teacher professional development; Dilemmas; Relief strategies
THE IMPACT OF CORPORATE ESG INFORMATION QUALITY ON AUDIT QUALITY: AN EMPIRICAL STUDY
Authors: Xie Weiyu  , Wu Hongman  , Lin Qijia
Published: December 2024

This study empirically examines the relationship between ESG information quality and audit quality using data from A-share listed companies in China from 2013 to 2023. The findings indicate that companies with higher ESG ratings tend to exhibit lower levels of earnings manipulation and higher audit quality. In terms of control variables, higher debt levels, corporate loss status, and a greater proportion of independent directors negatively impact audit quality. To ensure the robustness and stability of the results, this study employs fixed-effects models, lagged treatment, and instrumental variable methods (2SLS), with consistent conclusions. Therefore, strengthening ESG disclosure standards can not only enhance a company's market image and social responsibility but also indirectly improve external audit quality, promoting the healthy development of capital markets.
KEYWORDS: ESG, Information Quality, Audit Quality
ANALYSIS OF THE CURRENT STATE OF LIFE INSURANCE IN UZBEKISTAN AND DEVELOPMENT PROSPECTS
Authors: Hamroyeva Dilso‘z Yahyoyevna
Published: December 2024

This article is aimed at an in-depth analysis of the current state of life insurance in Uzbekistan, focusing on the main tasks facing the industry and studying future development prospects based on recent reforms and market trends. Also, the opportunities of Uzbekistan and foreign countries in terms of life insurance have been comparatively analyzed.
KEYWORDS: Life insurance, Uzbekistan insurance market, financial reforms, insurance penetration, cultural barriers, economic constraints, regulatory challenges, public awareness, digital insurance platforms, insurance product development.
ASSESSMENT OF POTENTIAL GNP IN UZBEKISTAN USING TIME SERIES METHODS
Authors: Djabbarov Rahimjon Abdullaevich
Published: December 2024

The article discusses the importance of potential GDP in macroeconomic analysis and forecasting, as well as its unique role. In particular, the estimation of potential GDP by time series methods will determine the pattern of change of potential GDP over time. Potential GDP estimated based on time series methods can be used mainly to obtain general information about the trend of potential GDP or to compare it with potential GDP based on another approach. The frequency and time interval will partly depend on the purpose of using the potential GDP. At the same time, an econometric analysis of potential GDP was carried out.
KEYWORDS. potential GDP, time series, function, econometric model, model parameters, forecast
STATISTICAL RESEARCH OF THE ACTIVITY OF AGRICULTURAL ENTERPRISES
Authors: Aysachev Abdulfotix Abdulfaizovich
Published: December 2024

This article examines statistical measures of agricultural enterprise performance, including production trends, financial performance, and challenges faced by these enterprises in a rapidly changing environment.
KEYWORDS: Agricultural Business Statistics, Global Agricultural Market Analysis, Agricultural Employment, Agricultural Production Trends, Agricultural Business Financials, Agricultural Business Issues.