bluuebunny/crossref_metadata_2025 huggingface dataset:
Single Nucleotide Variants (SNVs) of Angiotensin-Converting Enzymes (ACE1 and ACE2): A Plausible Explanation for the Global Variation in COVID-19 Prevalence
Authors: Atiku Saad Mahjub , Kasozi Dennis , Campbell Katrina
Published: April 2023

Background. Although it is common knowledge that the coronavirus disease of 2019 (COVID-19) and other viral infections have an uneven impact globally, the reasons for this are still indistinct. The absence of equivalent capacities worldwide in screening, testing, and reporting of cases is one of the ideas put forward to explain this discrepancy. The molecular developments are noteworthy, particularly the role played by single nucleotide polymorphisms (SNPs) in ACEs (ACE1 and ACE2). The virus can enter the host cell thanks to the transmembrane protein ACE2, which is a homolog of ACE1. Objectives. With a focus on the I/D genotype of ACE1 and the rs2285666 SNV of ACE2, we elucidated the prevalence of SNPs in ACE1 and ACE2 in various geographic locations. We examined the relationship between these SNPs and the global patterns of COVID-19 prevalence. Methods. 66 of the 127 articles obtained using PubMed, Google Scholar, and Google directly conformed to the search terms; geographical distribution of viral infections, the prevalence of COVID-19, ACE1, ACE2, SNPs, and prevalence of the DD genotype, and rs2285666. Results. The DD genotype of ACE1 and the rs2285666 SNV of ACE2 are vital in their gene expression and contribute greatly to viral disease susceptibility, development, and severity. There was generally a high prevalence of the DD genotype in Europe and America, where COVID-19 had a more devastating effect than in Asia and Africa. The prevalence of the SNV rs2285666 varied in the following order: East Asia> South Asia >America>Europe >Africa. However, there were conflicting agreements in the association of rs2285666 with COVID-19 susceptibility and prevalence. Conclusion. The ACE1 DD genotype and COVID-19 prevalence have been positively linked in a number of studies. The ACE2 rs2285666 SNV, however, has yielded no definitive results. To determine the relationship between these SNVs and COVID-19 incidence, more research is required.
Supplementary Data from Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer
Authors: Evans Kurt W. , Yuca Erkan , Scott Stephen S. , Zhao Ming , Paez Arango Natalia , Cruz Pico Christian X. , Saridogan Turcin , Shariati Maryam , Class Caleb A. , Bristow Christopher A. , Vellano Christopher P. , Zheng Xiaofeng , Gonzalez-Angulo Ana Maria , Su Xiaoping , Tapia Coya , Chen Ken , Akcakanat Argun , Lim Bora , Tripathy Debu , Yap Timothy A. , Francesco Maria Emilia Di , Draetta Giulio F. , Jones Philip , Heffernan Timothy P. , Marszalek Joseph R. , Meric-Bernstam Funda
Published: April 2023

Table S1, Table S2, Table S3, Table S4, Figure S1 - S21, Supplementary Figure Legends
Supplementary Figures from The Mutational Signature Comprehensive Analysis Toolkit (musicatk) for the Discovery, Prediction, and Exploration of Mutational Signatures
Authors: Chevalier Aaron , Yang Shiyi , Khurshid Zainab , Sahelijo Nathan , Tong Tong , Huggins Jonathan H. , Yajima Masanao , Campbell Joshua D.
Published: April 2023

Supplementary Figures and Legends in the order cited in the manuscript
Supplementary Table S2 from Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma
Authors: Schoen Robert E. , Boardman Lisa A. , Cruz-Correa Marcia , Bansal Ajay , Kastenberg David , Hur Chin , Dzubinski Lynda , Kaufman Sharon F. , Rodriguez Luz M. , Richmond Ellen , Umar Asad , Szabo Eva , Salazar Andres , McKolanis John , Beatty Pamela , Pai Reetesh K. , Singhi Aatur D. , Jacqueline Camille M. , Bao Riuye , Diergaarde Brenda , McMurray Ryan P. , Strand Carrie , Foster Nathan R. , Zahrieh David M. , Limburg Paul J. , Finn Olivera J.
Published: April 2023

MDSC Values by Vaccine Immune Response vs. Non-Response
Supplementary Figure 4 from FcRL5 as a Target of Antibody–Drug Conjugates for the Treatment of Multiple Myeloma
Authors: Elkins Kristi , Zheng Bing , Go MaryAnn , Slaga Dionysos , Du Changchun , Scales Suzie J. , Yu Shang-Fan , McBride Jacqueline , de Tute Ruth , Rawstron Andy , Jack Andrew S. , Ebens Allen , Polson Andrew G.
Published: April 2023

PDF file - 48KB, In vivo efficacy of anti-FcRL5-MC-vc-PAB-MMAE in combination with lenalidomide
Supplementary Figure 1 from Honokiol in Combination with Radiation Targets Notch Signaling to Inhibit Colon Cancer Stem Cells
Authors: Ponnurangam Sivapriya , Mammen Joshua M.V. , Ramalingam Satish , He Zhiyun , Zhang Youcheng , Umar Shahid , Subramaniam Dharmalingam , Anant Shrikant
Published: April 2023

PDF file - 1.8MB
Supplementary Figure 1 from Predominance of mTORC1 over mTORC2 in the Regulation of Proliferation of Ovarian Cancer Cells: Therapeutic Implications
Authors: Montero Juan Carlos , Chen Xi , Ocaña Alberto , Pandiella Atanasio
Published: April 2023

PDF file, 51KB, This Figure includes data on the proliferation of the four different ovarian cancer cell lines used, as well as a statistical analysis of the potential relationship between their proliferation rates and the level of activation of mTORC1 and mTORC2.
Supplementary Figure 1 from Therapeutic Targeting the Loss of the Birt-Hogg-Dubé Suppressor Gene
Authors: Lu Xiaohong , Wei Wenbin , Fenton Janine , Nahorski Michael S. , Rabai Erzsebet , Reiman Anne , Seabra Laurence , Nagy Zsuzsanna , Latif Farida , Maher Eamonn R.
Published: April 2023

Supplementary Figure 1 from Therapeutic Targeting the Loss of the Birt-Hogg-Dubé Suppressor Gene
Supplementary Table 3 from A Molecular Screening Approach to Identify and Characterize Inhibitors of Glioblastoma Stem Cells
Authors: Visnyei Koppany , Onodera Hideyuki , Damoiseaux Robert , Saigusa Kuniyasu , Petrosyan Syuzanna , De Vries David , Ferrari Denise , Saxe Jonathan , Panosyan Eduard H. , Masterman-Smith Michael , Mottahedeh Jack , Bradley Kenneth A. , Huang Jing , Sabatti Chiara , Nakano Ichiro , Kornblum Harley I.
Published: April 2023

PDF File - (39K) - Limiting dilution transplantation of GBM157 cells treated with OLDA, 5256360 or 5560509 shows decreased tumor formation frequency
Supplementary Figure 2 from Human Monoclonal Antibodies Targeting Nonoverlapping Epitopes on Insulin-like Growth Factor II as a Novel Type of Candidate Cancer Therapeutics
Authors: Chen Weizao , Feng Yang , Zhao Qi , Zhu Zhongyu , Dimitrov Dimiter S.
Published: April 2023

PDF file, 330KB, Schematic representation and SDS-PAGE analysis of the IGF-II-specific antibodies.
Supplementary Figure 4 from A Molecular Screening Approach to Identify and Characterize Inhibitors of Glioblastoma Stem Cells
Authors: Visnyei Koppany , Onodera Hideyuki , Damoiseaux Robert , Saigusa Kuniyasu , Petrosyan Syuzanna , De Vries David , Ferrari Denise , Saxe Jonathan , Panosyan Eduard H. , Masterman-Smith Michael , Mottahedeh Jack , Bradley Kenneth A. , Huang Jing , Sabatti Chiara , Nakano Ichiro , Kornblum Harley I.
Published: April 2023

PDF File - (67K) - Effects of OLDA, PALDA and NADA are not mediated via cannabinoid, vanilloid or dopamine receptors A - Exposure of GSC -enriched GBM 157 cells to CB1, CB2, TRPV1 receptor agonists or their combination, does not reproduce the phenotype seen after exposure to OLDA, PALDA or NADA. Graph showing ATP level expressed as % of DMSO treated controls. B - Exposure of OLDA, PALDA or NADA-pretreated GSC -enriched GBM 157 cells (at IC50 concentration) to antagonists of CB, TRPV and D receptors does not rescue the phenotype caused by OLDA, PALDA or NADA (B, C and D, respectively). The graphs are showing ATP levels expressed as % of the DMSO treated controls (100%). SE shown.
Supplementary Figure 2 from Triggering Fbw7-Mediated Proteasomal Degradation of c-Myc by Oridonin Induces Cell Growth Inhibition and Apoptosis
Authors: Huang Hui-Lin , Weng Heng-You , Wang Lu-Qin , Yu Chun-Hong , Huang Qiao-Juan , Zhao Pan-Pan , Wen Jun-Zhi , Zhou Hui , Qu Liang-Hu
Published: April 2023

PDF file - 58K, Regulation of oridonin on c-Myc.
Supplementary Figures 1-6 from Bortezomib Sensitizes Malignant Human Glioma Cells to TRAIL, Mediated by Inhibition of the NF-κB Signaling Pathway
Authors: Jane Esther P. , Premkumar Daniel R. , Pollack Ian F.
Published: April 2023

Supplementary Figures 1-6 from Bortezomib Sensitizes Malignant Human Glioma Cells to TRAIL, Mediated by Inhibition of the NF-κB Signaling Pathway
Supplementary Figure Legends 1-2, Table 1 from Navitoclax (ABT-263) Reduces Bcl-xL–Mediated Chemoresistance in Ovarian Cancer Models
Authors: Wong Maureen , Tan Nguyen , Zha Jiping , Peale Franklin V. , Yue Peng , Fairbrother Wayne J. , Belmont Lisa D.
Published: April 2023

PDF file - 44K
Supplementary Material from A Robust High-Content Imaging Approach for Probing the Mechanism of Action and Phenotypic Outcomes of Cell-Cycle Modulators
Authors: Sutherland Jeffrey J. , Low Jonathan , Blosser Wayne , Dowless Michele , Engler Thomas A. , Stancato Louis F.
Published: April 2023

Supplementary Material from A Robust High-Content Imaging Approach for Probing the Mechanism of Action and Phenotypic Outcomes of Cell-Cycle Modulators
Supplementary Table 2 from An Integrated Chemical Biology Approach Identifies Specific Vulnerability of Ewing's Sarcoma to Combined Inhibition of Aurora Kinases A and B
Authors: Winter Georg E. , Rix Uwe , Lissat Andrej , Stukalov Alexey , Müllner Markus K. , Bennett Keiryn L. , Colinge Jacques , Nijman Sebastian M. , Kubicek Stefan , Kovar Heinrich , Kontny Udo , Superti-Furga Giulio
Published: April 2023

XLS file - 11K
Supplementary Figure 5 from An Integrated Chemical Biology Approach Identifies Specific Vulnerability of Ewing's Sarcoma to Combined Inhibition of Aurora Kinases A and B
Authors: Winter Georg E. , Rix Uwe , Lissat Andrej , Stukalov Alexey , Müllner Markus K. , Bennett Keiryn L. , Colinge Jacques , Nijman Sebastian M. , Kubicek Stefan , Kovar Heinrich , Kontny Udo , Superti-Furga Giulio
Published: April 2023

PDF file - 402K
Supplementary Figure 2 from An Integrated Chemical Biology Approach Identifies Specific Vulnerability of Ewing's Sarcoma to Combined Inhibition of Aurora Kinases A and B
Authors: Winter Georg E. , Rix Uwe , Lissat Andrej , Stukalov Alexey , Müllner Markus K. , Bennett Keiryn L. , Colinge Jacques , Nijman Sebastian M. , Kubicek Stefan , Kovar Heinrich , Kontny Udo , Superti-Furga Giulio
Published: April 2023

PDF file - 53K
Supplementary Figure 1 from Overexpression of Mitotic Centromere–Associated Kinesin Stimulates Microtubule Detachment and Confers Resistance to Paclitaxel
Authors: Ganguly Anutosh , Yang Hailing , Cabral Fernando
Published: April 2023

Supplementary Figure 1 from Overexpression of Mitotic Centromere–Associated Kinesin Stimulates Microtubule Detachment and Confers Resistance to Paclitaxel
Supplementary Figure 3 from Integrin α6high Cell Population Functions as an Initiator in Tumorigenesis and Relapse of Human Liposarcoma
Authors: Wang Lu , Wang Lingxian , Gu Yanhong , Shu Yongqian , Shen Yan , Xu Qiang
Published: April 2023

PDF file - 46K, Knocking down the expression of CD13 leads to apoptosis in multiple cancer cells lines.
Supplementary Figure 1 from High-Risk Endometrial Carcinoma Profiling Identifies TGF-β1 as a Key Factor in the Initiation of Tumor Invasion
Authors: Muinelo-Romay Laura , Colas Eva , Barbazan Jorge , Alonso-Alconada Lorena , Alonso-Nocelo Marta , Bouso Marta , Curiel Teresa , Cueva Juan , Anido Urbano , Forteza Jeronimo , Gil-Moreno Antonio , Reventos Jaume , Lopez-Lopez Rafael , Abal Miguel
Published: April 2023

Supplementary Figure 1 from High-Risk Endometrial Carcinoma Profiling Identifies TGF-β1 as a Key Factor in the Initiation of Tumor Invasion
Supplementary Figure 1 from Integrin α6high Cell Population Functions as an Initiator in Tumorigenesis and Relapse of Human Liposarcoma
Authors: Wang Lu , Wang Lingxian , Gu Yanhong , Shu Yongqian , Shen Yan , Xu Qiang
Published: April 2023

PDF file - 107K, Integrin a6-and CD13-double positive rate in multiple cancer cell lines.
Supplementary Figure Legends 1-3 from Targeting the Microtubular Network as a New Antimyeloma Strategy
Authors: Feng Rentian , Li Shirong , Lu Caisheng , Andreas Carrie , Stolz Donna B. , Mapara Markus Y. , Lentzsch Suzanne
Published: April 2023

PDF file - 87K
Supplementary Figures 1-2 from Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy
Authors: Shrivastava Ashutosh , Kuzontkoski Paula M. , Groopman Jerome E. , Prasad Anil
Published: April 2023

Supplementary Figures 1-2 from Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy
Supplementary Figure 1 from Restitution of Tumor Suppressor MicroRNAs Using a Systemic Nanovector Inhibits Pancreatic Cancer Growth in Mice
Authors: Pramanik Dipankar , Campbell Nathaniel R. , Karikari Collins , Chivukula Raghu , Kent Oliver A. , Mendell Joshua T. , Maitra Anirban
Published: April 2023

Supplementary Figure 1 from Restitution of Tumor Suppressor MicroRNAs Using a Systemic Nanovector Inhibits Pancreatic Cancer Growth in Mice
Supplementary Figure 5 from A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability
Authors: Takekoshi Tomonori , Ziarek Joshua J. , Volkman Brian F. , Hwang Sam T.
Published: April 2023

PDF file, 58K, IC50 of CXCL122 for 10 nM wtCXCL12-induced THP-1 migration.
Supplementary Figure 3 from A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability
Authors: Takekoshi Tomonori , Ziarek Joshua J. , Volkman Brian F. , Hwang Sam T.
Published: April 2023

PDF file, 137K, Full length blot of Figure 3A.
Supplementary Figure 1 from A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability
Authors: Takekoshi Tomonori , Ziarek Joshua J. , Volkman Brian F. , Hwang Sam T.
Published: April 2023

PDF file, 28K, CXCL122 inhibited CXCR4-positive B16-F1 lung metastasis but did not affect CXCR4 B16-F1lung metastasis.
Supplementary Video 10 from Determinants of Mitotic Catastrophe on Abrogation of the G2 DNA Damage Checkpoint by UCN-01
Authors: On Kin Fan , Chen Yue , Tang Ma Hoi , Chow Jeremy P.H. , Poon Randy Y.C.
Published: April 2023

Supplementary Video 10 from Determinants of Mitotic Catastrophe on Abrogation of the G2 DNA Damage Checkpoint by UCN-01
Supplementary Table 1 from sFLT01: A Novel Fusion Protein with Antiangiogenic Activity
Authors: Bagley Rebecca G. , Kurtzberg Leslie , Weber William , Nguyen Tri-Hung , Roth Stephanie , Krumbholz Roy , Yao Min , Richards Brenda , Zhang Mindy , Pechan Peter , Schmid Steve , Scaria Abraham , Kaplan Johanne , Teicher Beverly A.
Published: April 2023

Supplementary Table 1 from sFLT01: A Novel Fusion Protein with Antiangiogenic Activity
Supplementary Methods, Figures 1-3 from Synergistic Antitumor Activity of Gemcitabine and ABT-737 In Vitro and In Vivo through Disrupting the Interaction of USP9X and Mcl-1
Authors: Zhang Chong , Cai Tian-yu , Zhu Hong , Yang Liu-qing , Jiang Hai , Dong Xiao-wu , Hu Yong-zhou , Lin Neng-ming , He Qiao-jun , Yang Bo
Published: April 2023

Supplementary Methods, Figures 1-3 from Synergistic Antitumor Activity of Gemcitabine and ABT-737 In Vitro and In Vivo through Disrupting the Interaction of USP9X and Mcl-1
Supplementary Methods, Figures 1-2, Tables 1-2 from Pharmacodynamic Evaluation of the Target Efficacy of SB939, an Oral HDAC Inhibitor with Selectivity for Tumor Tissue
Authors: Novotny-Diermayr Veronica , Sausgruber Nina , Loh Yung Kiang , Pasha Mohammed Khalid , Jayaraman Ramesh , Hentze Hannes , Yong Wei-Peng , Goh Boon-Cher , Toh Han-Chong , Ethirajulu Kantharaj , Zhu Joy , Wood Jeanette Marjorie
Published: April 2023

Supplementary Methods, Figures 1-2, Tables 1-2 from Pharmacodynamic Evaluation of the Target Efficacy of SB939, an Oral HDAC Inhibitor with Selectivity for Tumor Tissue
Supplementary Table 1 from Targeting Tyrosine Phosphorylation of PCNA Inhibits Prostate Cancer Growth
Authors: Zhao Huajun , Lo Yuan-Hung , Ma Li , Waltz Susan E. , Gray Jerilyn K. , Hung Mien-Chie , Wang Shao-Chun
Published: April 2023

Supplementary Table 1 from Targeting Tyrosine Phosphorylation of PCNA Inhibits Prostate Cancer Growth
Supplementary Figure 3 from Targeting Tyrosine Phosphorylation of PCNA Inhibits Prostate Cancer Growth
Authors: Zhao Huajun , Lo Yuan-Hung , Ma Li , Waltz Susan E. , Gray Jerilyn K. , Hung Mien-Chie , Wang Shao-Chun
Published: April 2023

Supplementary Figure 3 from Targeting Tyrosine Phosphorylation of PCNA Inhibits Prostate Cancer Growth
Supplement 4 from Melanoma Prognosis: A REMARK-Based Systematic Review and Bioinformatic Analysis of Immunohistochemical and Gene Microarray Studies
Authors: Schramm Sarah-Jane , Mann Graham J.
Published: April 2023

Supplement 4 from Melanoma Prognosis: A REMARK-Based Systematic Review and Bioinformatic Analysis of Immunohistochemical and Gene Microarray Studies
Supplementary Figure 1 from Trabectedin and Its C Subunit Modified Analogue PM01183 Attenuate Nucleotide Excision Repair and Show Activity toward Platinum-Resistant Cells
Authors: Soares Daniele G. , Machado Miriana S. , Rocca Céline J. , Poindessous Virginie , Ouaret Djamila , Sarasin Alain , Galmarini Carlos M. , Henriques João A.P. , Escargueil Alexandre E. , Larsen Annette K.
Published: April 2023

Supplementary Figure 1 from Trabectedin and Its C Subunit Modified Analogue PM01183 Attenuate Nucleotide Excision Repair and Show Activity toward Platinum-Resistant Cells
Supplementary Figure 2 from A YKL-40–Neutralizing Antibody Blocks Tumor Angiogenesis and Progression: A Potential Therapeutic Agent in Cancers
Authors: Faibish Michael , Francescone Ralph , Bentley Brooke , Yan Wei , Shao Rong
Published: April 2023

Supplementary Figure 2 from A YKL-40–Neutralizing Antibody Blocks Tumor Angiogenesis and Progression: A Potential Therapeutic Agent in Cancers
Supplementary Table 1 from Exon 11 Skipping of E-Cadherin RNA Downregulates Its Expression in Head and Neck Cancer Cells
Authors: Sharma Sanjai , Liao Wei , Zhou Xiaofeng , Wong David T.W. , Lichtenstein Alan
Published: April 2023

XLS file - 13K, List of 100 top most downregulated genes in the array. Average of 5 cell H&N cell lines compared to Tert Kert cells
Supplementary Table 1 from Death Receptor Pathway Activation and Increase of ROS Production by the Triple Epigenetic Inhibitor UVI5008
Authors: Nebbioso Angela , Pereira Raquel , Khanwalkar Harshal , Matarese Filomena , García-Rodríguez José , Miceli Marco , Logie Colin , Kedinger Valerie , Ferrara Felicetto , Stunnenberg Hendrik G. , de Lera Angel R. , Gronemeyer Hinrich , Altucci Lucia
Published: April 2023

PDF file - 68K
Supplementary Tables 1-2,Characterization Data & References from A Simplified Synthesis of Novel Dictyostatin Analogues with In Vitro Activity against Epothilone B–Resistant Cells and Antiangiogenic Activity in Zebrafish Embryos
Authors: Vollmer Laura L. , Jiménez Maria , Camarco Daniel P. , Zhu Wei , Daghestani Hikmat N. , Balachandran Raghavan , Reese Celeste E. , Lazo John S. , Hukriede Neil A. , Curran Dennis P. , Day Billy W. , Vogt Andreas
Published: April 2023

Supplementary Tables 1-2,Characterization Data & References from A Simplified Synthesis of Novel Dictyostatin Analogues with In Vitro Activity against Epothilone B–Resistant Cells and Antiangiogenic Activity in Zebrafish Embryos
Supplementary Figure 3 from Death Receptor Pathway Activation and Increase of ROS Production by the Triple Epigenetic Inhibitor UVI5008
Authors: Nebbioso Angela , Pereira Raquel , Khanwalkar Harshal , Matarese Filomena , García-Rodríguez José , Miceli Marco , Logie Colin , Kedinger Valerie , Ferrara Felicetto , Stunnenberg Hendrik G. , de Lera Angel R. , Gronemeyer Hinrich , Altucci Lucia
Published: April 2023

PDF file - 46K
Supplementary Figure 2 from Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Authors: Bielen Aleksandra , Perryman Lara , Box Gary M. , Valenti Melanie , de Haven Brandon Alexis , Martins Vanessa , Jury Alexa , Popov Sergey , Gowan Sharon , Jeay Sebastien , Raynaud Florence I. , Hofmann Francesco , Hargrave Darren , Eccles Suzanne A. , Jones Chris
Published: April 2023

Supplementary Figure 2 from Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Supplementary Methods, Figures 1-3, Table 1 from Acquisition of Resistance toward HYD1 Correlates with a Reduction in Cleaved α4 Integrin Expression and a Compromised CAM-DR Phenotype
Authors: Emmons Michael F. , Gebhard Anthony W. , Nair Rajesh R. , Baz Rachid , McLaughlin Mark L. , Cress Anne E. , Hazlehurst Lori A.
Published: April 2023

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Supplementary Figure 3 from Phenotypic Reversion of Invasive Neurofibromin-Deficient Schwannoma by FTS: Ras Inhibition Reduces BMP4/Erk/Smad Signaling
Authors: Barkan Batya , Kloog Yoel , Ehrlich Marcelo
Published: April 2023

Supplementary Figure 3 from Phenotypic Reversion of Invasive Neurofibromin-Deficient Schwannoma by FTS: Ras Inhibition Reduces BMP4/Erk/Smad Signaling
Supplementary Figure 6 from MEK/ERK Inhibitor U0126 Increases the Radiosensitivity of Rhabdomyosarcoma Cells In vitro and In vivo by Downregulating Growth and DNA Repair Signals
Authors: Marampon Francesco , Gravina Giovanni Luca , Di Rocco Agnese , Bonfili Pierluigi , Di Staso Mario , Fardella Caterina , Polidoro Lorella , Ciccarelli Carmela , Festuccia Claudio , Popov Vladimir M. , Pestell Richard G. , Tombolini Vincenzo , Zani Bianca Maria
Published: April 2023

Supplementary Figure 6 from MEK/ERK Inhibitor U0126 Increases the Radiosensitivity of Rhabdomyosarcoma Cells In vitro and In vivo by Downregulating Growth and DNA Repair Signals
Supplementary Figure 4 from In Situ Vaccination with CD204 Gene-Silenced Dendritic Cell, not Unmodified Dendritic Cell, Enhances Radiation Therapy of Prostate Cancer
Authors: Guo Chunqing , Yi Huanfa , Yu Xiaofei , Zuo Daming , Qian Jie , Yang Gary , Foster Barbara A. , Subjeck John R. , Sun Xiaolei , Mikkelsen Ross B. , Fisher Paul B. , Wang Xiang-Yang
Published: April 2023

PDF file, 1187K, DC-SRA shRNA vaccination following RT upregulates Granzyme B expression in tumor-infiltrating CD8+ cells.
Supplementary Tables 1-4, Figures 1-4 from Peloruside- and Laulimalide-Resistant Human Ovarian Carcinoma Cells Have βI-Tubulin Mutations and Altered Expression of βII- and βIII-Tubulin Isotypes
Authors: Kanakkanthara Arun , Wilmes Anja , O'Brate Aurora , Escuin Daniel , Chan Ariane , Gjyrezi Ada , Crawford Janet , Rawson Pisana , Kivell Bronwyn , Northcote Peter T. , Hamel Ernest , Giannakakou Paraskevi , Miller John H.
Published: April 2023

Supplementary Tables 1-4, Figures 1-4 from Peloruside- and Laulimalide-Resistant Human Ovarian Carcinoma Cells Have βI-Tubulin Mutations and Altered Expression of βII- and βIII-Tubulin Isotypes
Supplementary Figure 1 from Caspase-3–Dependent Mitotic Checkpoint Inactivation by the Small-Molecule Inducers of Mitotic Slippage SU6656 and Geraldol
Authors: Riffell Jenna L. , Jänicke Reiner U. , Roberge Michel
Published: April 2023

Supplementary Figure 1 from Caspase-3–Dependent Mitotic Checkpoint Inactivation by the Small-Molecule Inducers of Mitotic Slippage SU6656 and Geraldol
Supplementary Figure 3 from Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer
Authors: Li Jing , Cao Bo , Liu Xichun , Fu Xueqi , Xiong Zhenggang , Chen Li , Sartor Oliver , Dong Yan , Zhang Haitao
Published: April 2023

Supplementary Figure 3 from Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer
Supplementary Figure 2 from Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines
Authors: Santer Frédéric R. , Höschele Philipp P.S. , Oh Su Jung , Erb Holger H.H. , Bouchal Jan , Cavarretta Ilaria T. , Parson Walther , Meyers David J. , Cole Philip A. , Culig Zoran
Published: April 2023

Supplementary Figure 2 from Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines
Supplementary Figure 3 from Selective Targeting of Interferon γ to Stromal Fibroblasts and Pericytes as a Novel Therapeutic Approach to Inhibit Angiogenesis and Tumor Growth
Authors: Bansal Ruchi , Tomar Tushar , Östman Arne , Poelstra Klaas , Prakash Jai
Published: April 2023

PDF file, 1238K, Effect of the pPB-HSA-IFNγ conjugate on the infiltration of inflammatory cells in tumors (CD68+, CD4+ and CD8+ cells) and livers (CD68+).
Supplementary Figure 1 from The NEDD8-Activating Enzyme Inhibitor, MLN4924, Cooperates with TRAIL to Augment Apoptosis through Facilitating c-FLIP Degradation in Head and Neck Cancer Cells
Authors: Zhao Liqun , Yue Ping , Lonial Sagar , Khuri Fadlo R. , Sun Shi-Yong
Published: April 2023

PDF file - 48K
Supplementary Figure 2 from The Bcl-2/Bcl-XL/Bcl-w Inhibitor, Navitoclax, Enhances the Activity of Chemotherapeutic Agents In Vitro and In Vivo
Authors: Chen Jun , Jin Sha , Abraham Vivek , Huang Xiaoli , Liu Bernard , Mitten Michael J. , Nimmer Paul , Lin Xiaoyu , Smith Morey , Shen Yu , Shoemaker Alexander R. , Tahir Stephen K. , Zhang Haichao , Ackler Scott L. , Rosenberg Saul H. , Maecker Heather , Sampath Deepak , Leverson Joel D. , Tse Chris , Elmore Steven W.
Published: April 2023

PDF file - 40K
Supplementary Table 1 from NF-κB Is Required for Smac Mimetic-Mediated Sensitization of Glioblastoma Cells for γ-Irradiation–Induced Apoptosis
Authors: Berger Rebecca , Jennewein Claudia , Marschall Viola , Karl Sabine , Cristofanon Silvia , Wagner Liane , Vellanki Sri HariKrishna , Hehlgans Stephanie , Rödel Franz , Debatin Klaus-Michael , Ludolph Albert C. , Fulda Simone
Published: April 2023

PDF file-54KB
Supplementary Figure 2 from SAR131675, a Potent and Selective VEGFR-3–TK Inhibitor with Antilymphangiogenic, Antitumoral, and Antimetastatic Activities
Authors: Alam Antoine , Blanc Isabelle , Gueguen-Dorbes Geneviève , Duclos Olivier , Bonnin Jacques , Barron Pauline , Laplace Marie-Claude , Morin Gaelle , Gaujarengues Florence , Dol Frédérique , Hérault Jean-Pascal , Schaeffer Paul , Savi Pierre , Bono Françoise
Published: April 2023

PDF file - 76K, This file shows the pharmacokinetic parameters of SAR131675 and its effect on blood pressure
Supplementary Figure 2 from A Human Single-Domain Antibody Elicits Potent Antitumor Activity by Targeting an Epitope in Mesothelin Close to the Cancer Cell Surface
Authors: Tang Zhewei , Feng Mingqian , Gao Wei , Phung Yen , Chen Weizao , Chaudhary Amit , Croix Brad St. , Qian Min , Dimitrov Dimiter S. , Ho Mitchell
Published: April 2023

PDF file - 782K, Binding of the SS1, HN1 or SD1 VH domain to mesothelin (MSLN).
Supplementary Table 1 from Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents
Authors: Sharma Sharad , Zeng Jun-Ying , Zhuang Chun-Mei , Zhou Yong-Qing , Yao Hang-Ping , Hu Xing , Zhang Ruiwen , Wang Ming-Hai
Published: April 2023

PDF file - 66K, Supplementary Table 1 Inductive Effect of BMS-777607 on Breast Cancer Polyploid Cells with Different Numbers of Chromosomes.
Supplementary Figure 1 from Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents
Authors: Sharma Sharad , Zeng Jun-Ying , Zhuang Chun-Mei , Zhou Yong-Qing , Yao Hang-Ping , Hu Xing , Zhang Ruiwen , Wang Ming-Hai
Published: April 2023

PDF file - 63K, Figure S1: Expression of RON and MET by breast cancer MCF-7, T-47D and ZR-75-1 cells.
Supplementary Table 3 from Axl Mediates Acquired Resistance of Head and Neck Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Erlotinib
Authors: Giles Keith M. , Kalinowski Felicity C. , Candy Patrick A. , Epis Michael R. , Zhang Priscilla M. , Redfern Andrew D. , Stuart Lisa M. , Goodall Gregory J. , Leedman Peter J.
Published: April 2023

PDF - 706KB, Supplementary Table S3. Functional pathways associated with acquired erlotinib resistance in HN5-ER cells.
Supplementary Figure 3 from Apigenin Induces Apoptosis in Human Leukemia Cells and Exhibits Anti-Leukemic Activity In Vivo
Authors: Budhraja Amit , Gao Ning , Zhang Zhuo , Son Young-Ok , Cheng Senping , Wang Xin , Ding Songze , Hitron Andrew , Chen Gang , Luo Jia , Shi Xianglin
Published: April 2023

PDF file - 3.3MB
Supplementary Table 2 from Tumor Suppressor MicroRNA-493 Decreases Cell Motility and Migration Ability in Human Bladder Cancer Cells by Downregulating RhoC and FZD4
Authors: Ueno Koji , Hirata Hiroshi , Majid Shahana , Yamamura Soichiro , Shahryari Varahram , Tabatabai Z. Laura , Hinoda Yuji , Dahiya Rajvir
Published: April 2023

PDF file - 53K
Supplementary Figure 2 from GX15-070 (Obatoclax) Induces Apoptosis and Inhibits Cathepsin D- and L–Mediated Autophagosomal Lysis in Antiestrogen-Resistant Breast Cancer Cells
Authors: Schwartz-Roberts Jessica L. , Shajahan Ayesha N. , Cook Katherine L. , Wärri Anni , Abu-Asab Mones , Clarke Robert
Published: April 2023

Supplementary Figure 2 PDF file - 56K, GX induces apoptosis in breast cancer cells
Supplementary Figure 6 from Tumor Suppressor MicroRNA-493 Decreases Cell Motility and Migration Ability in Human Bladder Cancer Cells by Downregulating RhoC and FZD4
Authors: Ueno Koji , Hirata Hiroshi , Majid Shahana , Yamamura Soichiro , Shahryari Varahram , Tabatabai Z. Laura , Hinoda Yuji , Dahiya Rajvir
Published: April 2023

PDF file - 6.7MB
Supplementary Figure 5 from Tumor Suppressor MicroRNA-493 Decreases Cell Motility and Migration Ability in Human Bladder Cancer Cells by Downregulating RhoC and FZD4
Authors: Ueno Koji , Hirata Hiroshi , Majid Shahana , Yamamura Soichiro , Shahryari Varahram , Tabatabai Z. Laura , Hinoda Yuji , Dahiya Rajvir
Published: April 2023

PDF file - 140K
Supplementary Figure 5 from Crizotinib, a c-Met Inhibitor, Prevents Metastasis in a Metastatic Uveal Melanoma Model
Authors: Surriga Oliver , Rajasekhar Vinagolu K. , Ambrosini Grazia , Dogan Yildrim , Huang Ruimin , Schwartz Gary K.
Published: April 2023

PDF file - 892K, Supplementary Figure 5: Progression of metastasis post-treatment.
Supplementary Data 3 from Inhibition of p38 MAPK-Dependent Excision Repair Cross-Complementing 1 Expression Decreases the DNA Repair Capacity to Sensitize Lung Cancer Cells to Etoposide
Authors: Tsai Min-Shao , Weng Shao-Hsing , Chen Huang-Jen , Chiu Yu-Fan , Huang Yu-Ching , Tseng Sheng-Chieh , Kuo Ya-Hsun , Lin Yun-Wei
Published: April 2023

PDF file - 569K, etoposide structure
Supplementary Data 1 from Inhibition of p38 MAPK-Dependent Excision Repair Cross-Complementing 1 Expression Decreases the DNA Repair Capacity to Sensitize Lung Cancer Cells to Etoposide
Authors: Tsai Min-Shao , Weng Shao-Hsing , Chen Huang-Jen , Chiu Yu-Fan , Huang Yu-Ching , Tseng Sheng-Chieh , Kuo Ya-Hsun , Lin Yun-Wei
Published: April 2023

PDF file - 145K, SB202190 structure.
Supplementary Table 2 from An Integrated Genomic Approach to Identify Predictive Biomarkers of Response to the Aurora Kinase Inhibitor PF-03814735
Authors: Hook Kenneth E. , Garza Scott J. , Lira Maruja E. , Ching Keith A. , Lee Nathan V. , Cao Joan , Yuan Jing , Ye Jingjing , Ozeck Mark , Shi Stephanie T. , Zheng Xianxian , Rejto Paul A. , Kan Julie L.C. , Christensen James G. , Pavlicek Adam
Published: April 2023

XLS file - 6.7MB
Supplementary Figure 3 from An Integrated Genomic Approach to Identify Predictive Biomarkers of Response to the Aurora Kinase Inhibitor PF-03814735
Authors: Hook Kenneth E. , Garza Scott J. , Lira Maruja E. , Ching Keith A. , Lee Nathan V. , Cao Joan , Yuan Jing , Ye Jingjing , Ozeck Mark , Shi Stephanie T. , Zheng Xianxian , Rejto Paul A. , Kan Julie L.C. , Christensen James G. , Pavlicek Adam
Published: April 2023

PDF file - 233K
Supplementary Figure 1 from An Integrated Genomic Approach to Identify Predictive Biomarkers of Response to the Aurora Kinase Inhibitor PF-03814735
Authors: Hook Kenneth E. , Garza Scott J. , Lira Maruja E. , Ching Keith A. , Lee Nathan V. , Cao Joan , Yuan Jing , Ye Jingjing , Ozeck Mark , Shi Stephanie T. , Zheng Xianxian , Rejto Paul A. , Kan Julie L.C. , Christensen James G. , Pavlicek Adam
Published: April 2023

PDF file - 205K
Supplementary Table 1 from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer
Authors: Bhola Neil E. , Freilino Maria L. , Joyce Sonali C. , Sen Malabika , Thomas Sufi M. , Sahu Anirban , Cassell Andre , Chen Ching-Shih , Grandis Jennifer R.
Published: April 2023

PDF file, 39KB, IC50 values for AR-12 in HNC and 1 normal cell line.
Supplementary Table 3 from EGFR Exon 20 Insertion Mutations in Lung Adenocarcinomas: Prevalence, Molecular Heterogeneity, and Clinicopathologic Characteristics
Authors: Arcila Maria E. , Nafa Khedoudja , Chaft Jamie E. , Rekhtman Natasha , Lau Christopher , Reva Boris A. , Zakowski Maureen F. , Kris Mark G. , Ladanyi Marc
Published: April 2023

PDF file - 61K, Summary of all cases tested for EGFR exon 20 insertions
Supplementary Figure 5 from YM155 Reverses Cisplatin Resistance in Head and Neck Cancer by Decreasing Cytoplasmic Survivin Levels
Authors: Kumar Bhavna , Yadav Arti , Lang James C. , Cipolla Michael J. , Schmitt Alessandra C. , Arradaza Nicole , Teknos Theodoros N. , Kumar Pawan
Published: April 2023

PDF file, 828KB, YM155 treatment does not significantly affect mice body weight. Mice weights were measured on days 9, 18, 27 and 36.
Supplementary Figure 1 from Glycolysis Inhibition Sensitizes Non–Small Cell Lung Cancer with T790M Mutation to Irreversible EGFR Inhibitors via Translational Suppression of Mcl-1 by AMPK Activation
Authors: Kim Sun Mi , Yun Mi Ran , Hong Yun Kyoung , Solca Flavio , Kim Joo-Hang , Kim Hyun-Jung , Cho Byoung Chul
Published: April 2023

PDF file, 605K, The combined treatment of 2DG and afatinib induces selective cytotoxicity for cancer cells.
Supplementary Figure Legend from Peptidomimetic Src/Pretubulin Inhibitor KX-01 Alone and in Combination with Paclitaxel Suppresses Growth, Metastasis in Human ER/PR/HER2-Negative Tumor Xenografts
Authors: Anbalagan Muralidharan , Ali Alaa , Jones Ryan K. , Marsden Carolyn G. , Sheng Mei , Carrier Latonya , Bu Yahao , Hangauer David , Rowan Brian G.
Published: April 2023

PDF file, 43K.
Supplementary Figure 1 from A New Nonestrogenic Steroidal Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type I Blocks the Estrogen-Dependent Breast Cancer Tumor Growth Induced by Estrone
Authors: Ayan Diana , Maltais René , Roy Jenny , Poirier Donald
Published: April 2023

PDF file, 68K, Effect of PBRM, an inhibitor of 17b-HSD 1, and estrone (E1) on the body (A), uterine (B) and vaginal (C) weight of ovariectomized nude mice after 32 days of treatment. CTR: control.
Supplementary Figure 1 from Peptidomimetic Src/Pretubulin Inhibitor KX-01 Alone and in Combination with Paclitaxel Suppresses Growth, Metastasis in Human ER/PR/HER2-Negative Tumor Xenografts
Authors: Anbalagan Muralidharan , Ali Alaa , Jones Ryan K. , Marsden Carolyn G. , Sheng Mei , Carrier Latonya , Bu Yahao , Hangauer David , Rowan Brian G.
Published: April 2023

PDF file, 19K, KX-01 induces dose dependent apoptosis in dasatinib resistant MDA-MB-468 ER/PR/HER2-negative breast cancer cells.
Supplementary Figure 4 from Combining PARP-1 Inhibition and Radiation in Ewing Sarcoma Results in Lethal DNA Damage
Authors: Lee Hae-June , Yoon Changhwan , Schmidt Benjamin , Park Do Joong , Zhang Alexia Y. , Erkizan Hayriye V. , Toretsky Jeffrey A. , Kirsch David G. , Yoon Sam S.
Published: April 2023

PDF - 198KB, Pictures of clonogenic survival assay for shA673-1C cells treated with olaparib and radiation.
Supplementary Figure 3 from Combining PARP-1 Inhibition and Radiation in Ewing Sarcoma Results in Lethal DNA Damage
Authors: Lee Hae-June , Yoon Changhwan , Schmidt Benjamin , Park Do Joong , Zhang Alexia Y. , Erkizan Hayriye V. , Toretsky Jeffrey A. , Kirsch David G. , Yoon Sam S.
Published: April 2023

PDF - 46KB, Growth of HT1080 flank tumors in athymic nude mice treated with 8 Gy of radiation and olaparib
Supplementary Figures 1-2 from Autophagy Inhibition Synergistically Enhances Anticancer Efficacy of RAMBA, VN/12-1 in SKBR-3 Cells, and Tumor Xenografts
Authors: Godbole Abhijit M. , Purushottamachar Puranik , Martin Marlena S. , Daskalakis Constantine , Njar Vincent C.O.
Published: April 2023

PDF file - 585K
Supplementary Table 1 from ErbB3 Inhibitory Surrobodies Inhibit Tumor Cell Proliferation In Vitro and In Vivo
Authors: Foreman Pamela K. , Gore Medini , Kobel Philip A. , Xu Li , Yee Helena , Hannum Charles , Ho Hoangdung , Wang Sandra M. , Tran Hieu V. , Horowitz Michael , Horowitz Lawrence , Bhatt Ramesh R.
Published: April 2023

PDF file, 54KB, Surrobody Affinities Table.
Supplementary Methods and Materials from A Novel Antiandrogen, Compound 30, Suppresses Castration-Resistant and MDV3100-Resistant Prostate Cancer Growth In Vitro and In Vivo
Authors: Kuruma Hidetoshi , Matsumoto Hiroaki , Shiota Masaki , Bishop Jennifer , Lamoureux Francois , Thomas Christian , Briere David , Los Gerrit , Gleave Martin , Fanjul Andrea , Zoubeidi Amina
Published: April 2023

PDF, 34K, qRT-PCR primer sequences for SyberGreen qRT-PCR are listed
Supplementary Figure 2 from A Novel Antiandrogen, Compound 30, Suppresses Castration-Resistant and MDV3100-Resistant Prostate Cancer Growth In Vitro and In Vivo
Authors: Kuruma Hidetoshi , Matsumoto Hiroaki , Shiota Masaki , Bishop Jennifer , Lamoureux Francois , Thomas Christian , Briere David , Los Gerrit , Gleave Martin , Fanjul Andrea , Zoubeidi Amina
Published: April 2023

PDF, 43K, MDV3100 resistant cell line 49F expresses AR and PSA
Supplementary Tables 1 - 8 from Induction of Endoplasmic Reticulum Stress by Sorafenib and Activation of NF-κB by Lestaurtinib as a Novel Resistance Mechanism in Hodgkin Lymphoma Cell Lines
Authors: Holz Meike Stefanie , Janning Angela , Renné Christoph , Gattenlöhner Stefan , Spieker Tilmann , Bräuninger Andreas
Published: April 2023

PDF file - Supplementary Table S1. Primary antibodies for Western blot analysis. Supplementary Table S2. Primer sequences for qRT-PCR. Supplementary Table S3. TKIs and conventional chemotherapeutics used in this study. Supplementary Table S4. Sensitivity of Hodgkin-Reed/Sternberg cell lines to tyrosine kinase inhibitors (TKIs) at concentrations achievable in patients. Supplementary Table S5. Amount of phosphorylated RTK in relation to total RTK amount. Supplementary Table S6. Genes with increased expression upon lestaurtinib treatment of KM-H2 as determined by GeneChip Human 1.0 ST Arrays. Supplementary Table S7. Genes with decreased expression upon lestaurtinib treatment of KM-H2 as determined by GeneChip Human 1.0 ST Arrays. Supplementary Table S8. Gene ontology annotation of differentially expressed genes in lestaurtinib treated KM-H2 cells.
Supplementary Figures from The Functionalized Human Serine Protease Granzyme B/VEGF121 Targets Tumor Vasculature and Ablates Tumor Growth
Authors: Mohamedali Khalid A. , Cao Yu , Cheung Lawrence H. , Hittelman Walter N. , Rosenblum Michael G.
Published: April 2023

Supplementary Figures - PDF file 791K, Supplementary Figure 1. Representative image showing selective detection of CD-31+ pixels using MetaMorph 7.7 imaging software. The original image is shown in Figure 6B. Supplementary Figure 2. Original whole gel images of data depicted in Figure 1B. Lanes shown in Figure 1B are depicted by an asterisk. Gel 1: elution profile of Granzyme B/VEGF121 from HEK-293T conditioned media. Purity greater than 95% was obtained. Gel 2: Asterisked SDS-PAGE lanes show GrB/VEGF121 under reducing and non-reducing conditions, and show that the majority of the purified protein is a natural homodimer. Supplementary Figure 3. Total VEGFR-2 expression assessed by Western blot analysis (top) and flow cytometry (bottom). Corresponding western blot lanes for VEGFR-2 and Actin are numerically indicated. VEGFR-2 expression in bEND.3 cells was tested using both methods, and has been previously reported as 2 x 105 receptors per cell1. Supplementary Figure 4. Internalization of GrB/VEGF121 into PAE/VEGFR-1 is much lower than into PAE/VEGFR-2 cells. Cells were treated with 20 nM GrB/VEGF121 for 24 h, followed by removal of cell surface-bound protein as described in Methods. Cells were treated with mouse anti-GrB monoclonal antibody followed by a goat anti-mouse AF488 antibody. 1. Veenendaal LM, Jin H, Ran S, Cheung L, Navone N, Marks JW, Waltenberger J, Thorpe P, Rosenblum MG. In vitro and in vivo studies of a VEGF121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors. Proc Natl Acad Sci U S A 2002;99:7866-71.
Supplementary Figure 1 from Evaluating the Therapeutic Potential of a Non-Natural Nucleotide That Inhibits Human Ribonucleotide Reductase
Authors: Ahmad Md. Faiz , Wan Qun , Jha Shalini , Motea Edward , Berdis Anthony , Dealwis Chris
Published: April 2023

PDF file - 68K, Induction of ROS, DSB breaks and apoptosis in cells treated with vorinostat
Supplementary Figure 1 from A 71-Gene Signature of TRAIL Sensitivity in Cancer Cells
Authors: Chen Jun-Jie , Knudsen Steen , Mazin Wiktor , Dahlgaard Jesper , Zhang Baolin
Published: April 2023

PDF file - 139K, Supplement III.
Supplementary Primary Sequences from A Monoclonal Antibody against Human Notch1 Ligand–Binding Domain Depletes Subpopulation of Putative Breast Cancer Stem–like Cells
Authors: Sharma Ankur , Paranjape Anurag N. , Rangarajan Annapoorni , Dighe Rajan R.
Published: April 2023

PDF file - 83K
Supplementary Methods, Tables 1 - 4, Figures 1 - 10 from Isolation of a Novel Thioflavin S–Derived Compound That Inhibits BAG-1–Mediated Protein Interactions and Targets BRAF Inhibitor–Resistant Cell Lines
Authors: Enthammer Marion , Papadakis Emmanouil S. , Salomé Gachet Maria , Deutsch Martin , Schwaiger Stefan , Koziel Katarzyna , Ashraf Muhammad Imtiaz , Khalid Sana , Wolber Gerhard , Packham Graham , Cutress Ramsey I. , Stuppner Hermann , Troppmair Jakob
Published: April 2023

PDF file - 1877K, Supplementary Methods; Supplementary Table 1: 1H and 13C NMR shifts of Thio-2; Supplementary Table 2: 1H and 13C NMR shifts of Thio-3; Supplementary Table 3: 1H and 13C NMR shifts of Thio-5; Supplementary Table 4: 1H and 13C NMR shifts of Thio-6; Supplementary Figure 1: Spectral data Thio-2; Supplementary Figure 2: Spectral data Thio-3; Supplementry Figure 3: Spectral data Thio-5; Supplementary Figure 4: Spectral data Thio-2; Supplementary Figure 5: Cancer cell growth inhibition by Thio-2; Supplementary Figure 6: Effect of Thio-2 on intracellular signaling; Supplementary Figure 7: Effect of Thio-2 on cell survival; Supplementary Figure 8: Effect of Thio-2 on cell proliferation; Supplementary Figure 9: Thio-2 and BRAF protein stability; Supplementary Figure 10: Effect of Thio-2 protein-protein interaction (PPI)
Supplementary Figure Legends 1-10 from A Monoclonal Antibody against Human Notch1 Ligand–Binding Domain Depletes Subpopulation of Putative Breast Cancer Stem–like Cells
Authors: Sharma Ankur , Paranjape Anurag N. , Rangarajan Annapoorni , Dighe Rajan R.
Published: April 2023

PDF file - 63K
Supplementary Figure Legends from Inhibition of HSP90 with AUY922 Induces Synergy in HER2-Amplified Trastuzumab-Resistant Breast and Gastric Cancer
Authors: Wainberg Zev A. , Anghel Adrian , Rogers Amy M. , Desai Amrita J. , Kalous Ondrej , Conklin Dylan , Ayala Raul , O'Brien Neil A. , Quadt Cornelia , Akimov Mikhail , Slamon Dennis J. , Finn Richard S.
Published: April 2023

Supplementary Legends PDF file - 78K, Supplementary Figure Legends
Supplementary Figure 3 from Inhibition of HSP90 with AUY922 Induces Synergy in HER2-Amplified Trastuzumab-Resistant Breast and Gastric Cancer
Authors: Wainberg Zev A. , Anghel Adrian , Rogers Amy M. , Desai Amrita J. , Kalous Ondrej , Conklin Dylan , Ayala Raul , O'Brien Neil A. , Quadt Cornelia , Akimov Mikhail , Slamon Dennis J. , Finn Richard S.
Published: April 2023

Supplementary Figure 3 PDF file - 58K, Activation of HSP70 in both N87-Parental and N87-TRC cell lines
Supplementary Figure 5 from A Monoclonal Antibody against Human Notch1 Ligand–Binding Domain Depletes Subpopulation of Putative Breast Cancer Stem–like Cells
Authors: Sharma Ankur , Paranjape Anurag N. , Rangarajan Annapoorni , Dighe Rajan R.
Published: April 2023

PDF file - 1.8MB
Supplementary Table 2 from The Gamma Secretase Inhibitor MRK-003 Attenuates Pancreatic Cancer Growth in Preclinical Models
Authors: Mizuma Masamichi , Rasheed Zeshaan A. , Yabuuchi Shinichi , Omura Noriyuki , Campbell Nathaniel R. , de Wilde Roeland F. , De Oliveira Elizabeth , Zhang Qing , Puig Oscar , Matsui William , Hidalgo Manuel , Maitra Anirban , Rajeshkumar N.V.
Published: April 2023

XLSX file, 138K, Gene expression analysis for predictive signatures of response to MRK-003 plus GEM.
Supplementary Table 1 from The Gamma Secretase Inhibitor MRK-003 Attenuates Pancreatic Cancer Growth in Preclinical Models
Authors: Mizuma Masamichi , Rasheed Zeshaan A. , Yabuuchi Shinichi , Omura Noriyuki , Campbell Nathaniel R. , de Wilde Roeland F. , De Oliveira Elizabeth , Zhang Qing , Puig Oscar , Matsui William , Hidalgo Manuel , Maitra Anirban , Rajeshkumar N.V.
Published: April 2023

XLSX file, 105K, Gene expression analysis for predictive signatures of response to MRK-003.
Supplementary Figure 10 from A Monoclonal Antibody against Human Notch1 Ligand–Binding Domain Depletes Subpopulation of Putative Breast Cancer Stem–like Cells
Authors: Sharma Ankur , Paranjape Anurag N. , Rangarajan Annapoorni , Dighe Rajan R.
Published: April 2023

PDF file - 77K
Supplementary Table 4 from Molecular Predictors of Sensitivity to the Insulin-like Growth Factor 1 Receptor Inhibitor Figitumumab (CP-751,871)
Authors: Pavlicek Adam , Lira Maruja E. , Lee Nathan V. , Ching Keith A. , Ye Jingjing , Cao Joan , Garza Scott J. , Hook Kenneth E. , Ozeck Mark , Shi Stephanie T. , Yuan Jing , Zheng Xianxian , Rejto Paul A. , Kan Julie L.C. , Christensen James G.
Published: April 2023

PDF file - 23K, Summary of figitumumab potency in selected cell lines in vitro and tumor growth inhibition for cell lines growth as subcutaneous tumor xenografts.
Supplementary Table 3 from Molecular Predictors of Sensitivity to the Insulin-like Growth Factor 1 Receptor Inhibitor Figitumumab (CP-751,871)
Authors: Pavlicek Adam , Lira Maruja E. , Lee Nathan V. , Ching Keith A. , Ye Jingjing , Cao Joan , Garza Scott J. , Hook Kenneth E. , Ozeck Mark , Shi Stephanie T. , Yuan Jing , Zheng Xianxian , Rejto Paul A. , Kan Julie L.C. , Christensen James G.
Published: April 2023

PDF file - 33K, Figitumumab sensitivity gene target correlates rank ordered by statistical significance and annotated with false discovery rates and chromosomal positions of gene locations.
Supplementary Material: DLDA classifiers IGF Pathway Score from Molecular Predictors of Sensitivity to the Insulin-like Growth Factor 1 Receptor Inhibitor Figitumumab (CP-751,871)
Authors: Pavlicek Adam , Lira Maruja E. , Lee Nathan V. , Ching Keith A. , Ye Jingjing , Cao Joan , Garza Scott J. , Hook Kenneth E. , Ozeck Mark , Shi Stephanie T. , Yuan Jing , Zheng Xianxian , Rejto Paul A. , Kan Julie L.C. , Christensen James G.
Published: April 2023

PDF file - 100K, Supplementary summary of performance of DLDA classifiers across cell lines including cell line classification and mean number of genes in classifier and including classifier compositions rank ordered by t value.
Supplementary Table 1 from Identification and Characterization of MEL-3, a Novel AR Antagonist That Suppresses Prostate Cancer Cell Growth
Authors: Helsen Christine , Marchand Arnaud , Chaltin Patrick , Munck Sebastian , Voet Arnout , Verstuyf Annemieke , Claessens Frank
Published: April 2023

PDF file, 46KB, The cell cycle distribution of LAPC4 cells is affected by MEL-3.
Supplementary Table 1 from A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo
Authors: Liu Yi , Cao Yanyan , Zhang Weihe , Bergmeier Stephen , Qian Yanrong , Akbar Huzoor , Colvin Robert , Ding Juan , Tong Lingying , Wu Shiyong , Hines Jennifer , Chen Xiaozhuo
Published: April 2023

PDF file, 122KB, Body composition of WZB117 treated tumor-bearing mice.