bluuebunny/crossref_metadata_2025 huggingface dataset:
Mental health literacy among Arab university students in Israel: A qualitative study
Authors: Khatib Anwar , Abo-Rass Fareeda
Published: August 2021

Background:

There has been a noticeable increase in the number of studies concerned with mental health literacy (MHL), specifically among students. Still, very few studies have examined MHL among students of non-Western minority groups.

Aims:

This study examined MHL among Arab students in Israel based on Jorm’s conceptual framework.

Methods:

Twenty-eight Arab students in Israel took part in semi-structured, in-depth interviews. Most were single and Muslim, in their second year of studies, and most reported low socioeconomic status. The data were analyzed thematically, guided by the Jorm’s six MHL dimensions.

Results:

Different levels of literacy were found in the various MHL dimensions. The participants identified severe mental disorders more easily than mood disorders; reported a variety of possible causes of mental disorders; were well aware of available professional help (apart for rehabilitative services); identified significant barriers to mental health help seeking, as Arabs; and reported the internet as a major source of information about mental health problems and their treatment

Conclusions:

The participants’ MHL appeared to be associated with their unique sociocultural characteristics. This study stresses the need to raise MHL among Arab students in Israel, and in particular to promote positive attitudes to seeking professional help. It also highlights the need to develop culturally adapted mental health interventions for the Arab population in Israel.
Is Ethnonationalism Growing in Ethiopia and Will it Lead to the Dissolution of the Country? Evidence from the World Value Survey 2007–2020
Authors: Ishiyama John
Published: August 2021

In this paper, I examine whether ethnopolitical identities have grown in Ethiopia since the introduction of Prime Minister Abiy Ahmed’s reforms in 2018, using the most recent Ethiopian survey data from the World Values Survey (wave 5, from 2007 and wave 7, from 2020). I find that although there remains a general popular commitment to a national (Ethiopian) identity, among younger people (especially males) there is a growing sense of an “ethnic” identity and a growing intolerance of other ethnic groups. Further, I find that those who express ethnonational identities are significantly more likely to engage in protest and demonstrations. In conclusion, I suggest that this may not portend well for the future of Ethiopian unity. I also suggest that whether this happens also depends on the institutional transformation of the Prosperity Party (the successor the Ethiopian People’s Revolutionary Democratic Front (EPRDF)) and the level of external support the regime receives from its foreign benefactors.
Gender and the politics of war historiography in Buchi Emecheta’s Destination Biafra
Authors: Jilani Sarah
Published: August 2021

Buchi Emecheta’s novel about the Nigerian Civil War, Destination Biafra (1982), challenges war historiography in ways that scholarship designating it a “female perspective” on the conflict can sometimes overlook. This article focuses on how Emecheta deploys a dual narrative approach that weaves an omniscient narrator with diverse Nigerian women’s points of view in order to position their lived experiences and subjective knowledges as collectively amounting to the definitive history of the Civil War. This draws the reader’s attention to the gendered effects of the civil war as the lens whereby which all facets of the war can be understood - even and especially its macro causes in neocolonialism and petrocapitalism. By writing women who know the economic imperatives behind the conflict; exercise agency under dangerous circumstances; and employ methods of survival that safeguard others, Emecheta reveals the gendered politics of war historiography, and tests these politics by collapsing distinctions between what is habitually conceived of as the war front (and therefore to be narrated by active combatants), and everywhere else (to be narrated by witnesses, refugees, or survivors). Destination can therefore be understood as an attempt to intervene directly in historiographical method, as it rejects the designation of women’s war experiences as mere addenda and questions gendered expectations of where to look for and find historical truths.
Degradable RGD-Functionalized 3D-Printed Scaffold Promotes Osteogenesis
Authors: Chang P.-C. , Lin Z.-J. , Luo H.-T. , Tu C.-C. , Tai W.-C. , Chang C.-H. , Chang Y.-C.
Published: August 2021

To establish an ideal microenvironment for regenerating maxillofacial defects, recent research interests have concentrated on developing scaffolds with intricate configurations and manipulating the stiffness of extracellular matrix toward osteogenesis. Herein, we propose to infuse a degradable RGD-functionalized alginate matrix (RAM) with osteoid-like stiffness, as an artificial extracellular matrix, to a rigid 3D-printed hydroxyapatite scaffold for maxillofacial regeneration. The 3D-printed hydroxyapatite scaffold was produced by microextrusion technology and showed good dimensional stability with consistent microporous detail. RAM was crosslinked by calcium sulfate to manipulate the stiffness, and its degradation was accelerated by partial oxidation using sodium periodate. The results revealed that viability of bone marrow stem cells was significantly improved on the RAM and was promoted on the oxidized RAM. In addition, the migration and osteogenic differentiation of bone marrow stem cells were promoted on the RAM with osteoid-like stiffness, specifically on the oxidized RAM. The in vivo evidence revealed that nonoxidized RAM with osteoid-like stiffness upregulated osteogenic genes but prevented ingrowth of newly formed bone, leading to limited regeneration. Oxidized RAM with osteoid-like stiffness facilitated collagen synthesis, angiogenesis, and osteogenesis and induced robust bone formation, thereby significantly promoting maxillofacial regeneration. Overall, this study supported that in the stabilized microenvironment, oxidized RAM with osteoid-like stiffness offered requisite mechanical cues for osteogenesis and an appropriate degradation profile to facilitate bone formation. Combining the 3D-printed hydroxyapatite scaffold and oxidized RAM with osteoid-like stiffness may be an advantageous approach for maxillofacial regeneration.
Dental Mitigation Strategies to Reduce Aerosolization of SARS-CoV-2
Authors: Vernon J.J. , Black E.V.I. , Dennis T. , Devine D.A. , Fletcher L. , Wood D.J. , Nattress B.R.
Published: August 2021

Limiting infection transmission is central to the safety of all in dentistry, particularly during the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Aerosol-generating procedures (AGPs) are crucial to the practice of dentistry; it is imperative to understand the inherent risks of viral dispersion associated with AGPs and the efficacy of available mitigation strategies. In a dental surgery setting, crown preparation and root canal access procedures were performed with an air turbine or high-speed contra-angle handpiece (HSCAH), with mitigation via rubber dam or high-volume aspiration and a no-mitigation control. A phantom head was used with a 1.5-mL min−1 flow of artificial saliva infected with Φ6-bacteriophage (a surrogate virus for SARS-CoV-2) at ~108 plaque-forming units mL−1, reflecting the upper limits of reported salivary SARS-CoV-2 levels. Bioaerosol dispersal was measured using agar settle plates lawned with the Φ6-bacteriophage host, Pseudomonas syringae. Viral air concentrations were assessed using MicroBio MB2 air sampling and particle quantities using Kanomax 3889 GEOα counters. Compared to an air turbine, the HSCAH reduced settled bioaerosols by 99.72%, 100.00%, and 100.00% for no mitigation, aspiration, and rubber dam, respectively. Bacteriophage concentrations in the air were reduced by 99.98%, 100.00%, and 100.00% with the same mitigations. Use of the HSCAH with high-volume aspiration resulted in no detectable bacteriophage, both on nonsplatter settle plates and in air samples taken 6 to 10 min postprocedure. To our knowledge, this study is the first to report the aerosolization in a dental clinic of active virus as a marker for risk determination. While this model represents a worst-case scenario for possible SARS-CoV-2 dispersal, these data showed that the use of HSCAHs can vastly reduce the risk of viral aerosolization and therefore remove the need for clinic fallow time. Furthermore, our findings indicate that the use of particle analysis alone cannot provide sufficient insight to understand bioaerosol infection risk.
Health-Related and Motor Performance-Related Fitness and Physical Activity Among Youth With Cystic Fibrosis
Authors: Gruber Wolfgang , Welsner Matthias , Dillenhöfer Stefanie , Olivier Margarete , Koerner-Rettberg Cordula , Sutharsan Sivagurunathan , Taube Christian , Mellies Uwe , Stehling Florian
Published: August 2021

Little is known about motor competence and the longitudinal development of motor performance among youth with cystic fibrosis (CF). In this study, we assessed aspects of motor performance in different age groups of young patients with CF and compared them with a healthy reference group of same aged children. We also examined the development of motor performance among different age groups of these children with CF, using The Deutscher Motorik Test (DMT) to assess attributes of health-related and motor performance-related fitness. We used an incremental ergometer cycle test to determine maximal exercise capacity (expressed as peak workload). We evaluated and recorded habitual physical activity (PA) as measured by the number of steps per day and the time spent in different PA intensities (expressed in metabolic equivalents). In total, 31 children and adolescents with CF agreed to participate (13 girls,18 boys) aged 6–17 years ( M = 11.3, SD =3.3 years); they had a mean one second forced expiratory volume (expressed as a percentage of predicted value [% pred]) of 87.2% ( SD = 22.3%). We found their values of health-related and motor performance-related fitness to be significantly lower ( p < 0.05) than those of their healthy peer participants. In contrast to the reference group, participants with CF up to 14 years of age showed a linear improvement in these values and in their PA, followed by a plateau or even a nonsignificant decrease after age 14. These findings have important implications for the development and prescription of exercise programs for children with CF. Besides aerobic and strength exercises, we recommend that neuromuscular training be integrated into exercise programs to improve the coordinative abilities of youth with CF. More attention should be paid to vulnerable older adolescents to ensure their long-term motivation to maintain exercise participation.
Psychometric Assessment of the Persian Translated Version of the Romantic Perfectionism Scale Among Couples
Authors: Abdollahi Abbas , Allen Kelly A.
Published: August 2021

Romantic perfectionismi can be disruptive to relationships, yet no validated measure for assessing romantic perfectionism in Iranian couples has been developed. Therefore, the purpose of this study was to translate and validate the Romantic Perfectionism Scale (RPS) among Iranian couples. Participants in the study were 200 married men and 320 married women from Tehran, Iran, who completed the translated RPS, the Almost Perfect Scale-Revised, and the Depression Anxiety Stress Scale-21 online. Item impact scores were used to calculate face validity. Impact score values for all items were greater than 1.5, signaling appropriate face validity.. The Content Validity Index (CVI) and the Content Validity Ratio (CVR) were used to measure content validity. Values of the CVI were above the cut-off score of 0.7, implying satisfactory content validity of the items. The CVR values were greater than the Lawshe table (0.78) cut-off score, demonstrating that all items were essential. Confirmatory Factor Analysis (CFA) using AMOS software was used to evaluate the construct validity. The results of the goodness of fit indices confirmed the RPS with two subscales (i.e., self-oriented romantic perfectionism and other-oriented romantic perfectionism) as per the original scale. All items remained in the scale as all factor loading values were greater than 0.45. The findings showed that the two subscales, and the scale as a whole, had acceptable internal consistency, as the construct reliability values for self-oriented romantic perfectionism (0.81), other-oriented romantic perfectionism (0.72), and the whole scale (0.74) were greater than 0.7. The results support the psychometric properties of the Iranian version of the RPS, which could be used by future researchers and clinicians to assess romantic perfectionism in Iranian couples.
Displaying family at a women’s refuge
Authors: Henze-Pedersen Sofie , Järvinen Margaretha
Published: August 2021

This article explores the family relationships of mothers and children living at a women’s refuge because of intimate partner violence. Theoretically, the article contributes to the sociological literature analysing family relationships in terms of ‘doing’ and ‘displaying’ rather than ‘being’ a family. Empirically, it is based on ethnographic fieldwork and semi-structured interviews with children living at a refuge in Denmark. The article shows that family display at the refuge is conducted by both mothers and children and sometimes in conflicting ways, not least when it comes to the question of how to define the position of the father (who has committed the violence) in the family’s future life. This highlights how display – as an evaluative practice – can be done in different ways in order to protect or reject family relationships, both internally and when addressing external audiences. Furthermore, the article analyses family relationships in a semi-public setting (the refuge) where powerful audiences are active interpreters of the family display enacted, and participants in decisions concerning the families’ futures.
Seeking Just Us: A Mixed Methods Investigation of Racism-Specific Support Among Black College Students
Authors: Marshburn Christopher K. , Campos Belinda
Published: August 2021

Social support is theorized to protect health against the negative effects of stress. However, findings are mixed regarding whether social support protects Black people’s psychological well-being against racism. The current mixed methods study examined racism-specific support (RSS)—social support in response to racism—in same- (Black/Black) and cross-race (Black/non-Black) friendships. We investigated whether 31 Black college students ( M age = 19.7, SD = 1.70; 74% women) had (1) racial preferences (same-vs. cross-race) for whom they sought RSS, and (2) whether perceptions of RSS’s helpfulness differed when provided by cross-race friends. Participants completed measures of emotional closeness to same- and cross-race friends and participated in focus group interviews discussing racism and RSS. Results found participants reported more emotional closeness to Black friends and non-Black friends of color relative to White friends. As predicted, 65% of participants preferred RSS from Black (vs. non-Black) friends. Participants’ qualitative responses ( n = 21–24) revealed Black (vs. non-Black) friends were perceived to better understand racism. These findings suggest RSS from Black friends, specifically, might benefit Black college students’ psychological well-being.
Traumatic past in the present: COVID-19 and Holocaust memory in Israeli media, digital media, and social media
Authors: Steir-Livny Liat
Published: August 2021

The COVID-19 pandemic began in 2019, spread to the rest of the world in 2020 and still holds nations in its grip in 2021. There is scant research on the way it has affected Holocaust awareness. Based on scholarly work on Holocaust awareness in Israel, the top-down memory of the Holocaust in the media and the vernacular Holocaust memory on social media, this article analyzes the ways the Holocaust became a frame of reference in Israel for the interpretation of the COVID-19 pandemic and the newest link in a long chain of using the Holocaust as a prism for other topics in Israeli society. The article centers on the evolution of the COVID-19 – Holocaust references and the role of media and social media in it. It shows that the initial panic created a wave of comparisons between the Holocaust and the pandemic in the media and social media. In the second half of the year, as the restrictions and two more lockdowns became part of life, references to the Holocaust changed – negative reactions to COVID-19 government regulations and law enforcement were compared on social media to Nazi acts. The Israeli media did not create these comparisons but reported them widely and contributed to their circulation.
Gender differences in inhibitory control as assessed on simple delay tasks in early childhood: A meta-analysis
Authors: Silverman Irwin W.
Published: August 2021

Bjorklund and Kipp (1996) hypothesized that due to selection processes operative during human evolution, females have an inborn advantage over males in the ability to suppress inappropriate responses on tasks in the behavioral and social domains. To test this hypothesis, a meta-analysis was conducted on gender differences on simple delay tasks in which the participant is required to wait for a “go” signal before making an approach response to an enticing stimulus. The meta-analysis was performed on 113 effect sizes derived from 102 studies of 21,378 children who ranged in age from 1 year to 9 years and who lived in at least 15 countries. As hypothesized, girls exceeded boys in delay ability, with the gender differences being small in magnitude (Hedges’ g = .25–.26). The female advantage in delay ability held for both U.S. and non-U.S. samples of children. Further analyses found that girls outperformed boys on each of four simple delay tasks. Although the magnitude of the gender difference on the individual simple delay tasks did not differ as a function of age, the age ranges covered were narrow. Discussion focuses on two issues: (a) whether gender differences in delay ability can be explained by a factor other than inhibitory control and (b) whether parental socialization processes can explain the gender differences in delay ability. The evidence reviewed does not provide substantial support for either of these possibilities.
The Impact of Functional and Structural Maturation of the Kidney on Susceptibility to Drug and Chemical Toxicity in Neonatal Rodents
Authors: Frazier Kendall S.
Published: August 2021

Drug responses are often unpredictable in juvenile animal toxicity studies; hence, optimizing dosages is challenging. Renal functional differences based on age of development will often result in vastly different toxicologic responses. Developmental changes in renal function can alter plasma clearance of compounds with extensive renal elimination. Absorption, distribution, metabolism, and excretion of drugs vary depending on animal age and kidney maturation. Toxicity can result in malformations or renal degeneration. Although renal morphologic development in humans generally occurs in utero, maximal levels of tubular secretion, acid–base equilibrium, concentrating ability, or glomerular filtration rate (GFR) are reached postnatally in humans and animals and subject to drug effects. Maturation of renal metabolism and transporters occurs postnatally and plays a critical role in detoxification and excretion. Maturation times must be considered when designing juvenile toxicity studies and may require cohorts of animals of specific ages to achieve optimal dosing schemes and toxicokinetics. In recent years, critical end points and windows of susceptibility have been established comparatively between species to better model pharmacokinetics and understand pediatric nephrotoxicity. There are examples of agents where toxicity is enhanced in neonates, others where it is diminished, and others where rat nephrotoxicity is expressed as juvenile toxicity, but in humans as gestational toxicity.
Diversity in cardiothoracic surgery: The time has come
Authors: Moon Marc R
Published: August 2021

Historically, cardiothoracic surgery has been one of the least diverse specialties in medicine. There has been progress during the last 20 years, but we are far from equality in regard to gender or racial and ethnic makeup of the cardiothoracic surgical workforce. This phenomenon is not isolated to America, but exists throughout the globe. Diversity has been shown to improve productivity and profits in manufacturing and other fields. In addition, diversity has been shown to improve outcomes in select patient populations with a wide range of chronic and acute medical conditions. So, what can we do about it? This article summarizes the current situation in regard to equality and equity in cardiothoracic surgery and proposes solutions to bring about lasting change. Diversity in cardiothoracic surgery will not occur passively. It will require a concerted effort and a commitment to change.
Transformation of a Sacred Landscape: Veneration of Amun-Re in Graffiti in the Valley of the Kings
Authors: Ragab Muhammad R.
Published: August 2021

More than 4000 graffiti are scattered throughout the Theban necropolis. Among them, around 2500 graffiti can be dated to Nineteenth, Twentieth, and Twenty-First Dynasties. These New Kingdom graffiti were made by members of the community of workmen from Deir el-Medina. Only a small group of no more than 120 graffiti consist of depictions of deities and veneration scenes. The interpretation of graffiti with depictions of Amun-Re on rock surfaces in the Valley of the Kings reveals valuable information regarding their locations. This study thus attempts to identify particular locations in the valley where the workmen of Deir el-Medina venerated Amun-Re in different forms. These spots may have been considered to be of religious significance to the workmen of Deir el-Medina.
The relationship between historical redlining and Census Bureau Community Resilience Estimates in Columbus, Ohio
Authors: Asher Lila
Published: August 2021

Redlining refers to the officially sanctioned practice of denying mortgage loans in some areas in order to racially discriminate against Black people and other people of colour. Recent studies have shown the persistent impacts of redlining on health risks in effected neighbourhoods. This study contributes to that growing body of work by analysing the relationship between the category that neighbourhoods were assigned on redlining maps and the percentage of the population with 3+ risk factors as defined by the Census Bureau's Community Resilience Estimates. The areas given the lowest redlining grade of D are significantly different than those given the grades of A or B and the areas not graded at the time. This result supports the argument that historical governance and planning decisions do not stay in the past and planners must work to rectify equity issues lest we be complicit in this pattern of racial discrimination.
Are Wearable Sensors Valid and Reliable for Studying the Baseball Pitching Motion? An Independent Comparison With Marker-Based Motion Capture
Authors: Camp Christopher L. , Loushin Stacy , Nezlek Stuart , Fiegen Anthony P. , Christoffer Dan , Kaufman Kenton
Published: August 2021

Background:

In recent years, the prevalence of medial ulnar collateral ligament injuries has increased in throwers of all ages and skill levels. The motusBASEBALL sensor possesses an inertial measurement unit (IMU) that has been developed and applied to the throwing arm to allow for measurements of several objective parameters, which may prove beneficial for monitoring, rehabilitation, and injury prevention in the throwing athlete. However, the reliability, consistency, and validity of the IMU have not been independently assessed.

Purpose:

To evaluate the reliability, consistency, and validity of the motusBASEBALL sensor compared with the historic gold standard of marker-based motion capture.

Study Design:

Controlled laboratory study.

Methods:

A total of 10 healthy male baseball athletes with varsity-level high school experience volunteered to participate in this study. Participants were fitted with 37 retroreflective markers for motion capture and the motusBASEBALL IMU sensor. Participants threw 5 fastballs at maximum effort, with measurements recorded simultaneously by motion capture and the IMU. Arm slot, arm speed, arm stress, and shoulder rotation were measured and compared.

Results:

Of the 4 metrics generated by the IMU, significant differences were found for 3 of the throwing metrics compared with motion capture including arm slot (5.0°± 6.1°; P = .037), elbow varus torque (9.4 ± 12.0 N·m; P = .037), and shoulder rotation (6.3°± 6.1°; P = .014). Arm speed did not demonstrate a statistically significant difference (29.2 ± 96.8 rpm; P = .375). The IMU consistently underreported pitching performance values. Shoulder rotation exhibited excellent reliability with <5° of error, and arm slot demonstrated good reliability with <10° of error. Arm stress and arm speed were less reliable.

Conclusion:

The IMU was not accurate or valid for arm slot, arm stress, and shoulder rotation compared with marker-based motion capture. It was relatively accurate for arm speed. Despite its lack of validity, it was consistent and reliable for arm speed and shoulder rotation and relatively reliable for arm slot and arm stress. Caution should be used when comparing values provided by this IMU to the gold standard of marker-based motion capture.

Clinical Relevance:

IMU technology has potential to be used in monitoring, rehabilitation, and injury prevention in throwing athletes if valid. This study demonstrates that the values provided by the IMU should not be considered equivalent to those generated by the gold standard of marker-based motion capture; however, there may still be a role for this technology when relying on its internal consistency for intrathrower comparisons and tracking.
Belt width optimization for tire durability enhancement
Authors: Hongling Li , Yude Dong , Lei Qiu , Juxin Sun
Published: August 2021

Tire burst is one of the hot issues in automobile market. Based on the tire burst problem of all-steel radial tire, the shear strain and strain energy density at the end of the belt layer are analyzed to extend the tire durability. A multi-objective optimization model was established by finite element analysis, and the function constraints conditions were set. The optimization scheme was determined using differential evolution (DE) method. The finite element simulation and the durability test of tire specimen show that tire performance has greatly improved after the optimization. The results show that the combination of the finite element analysis technique and the multi-objective optimization method can effectively reduce a lot of labor, material, and financial resources in the structural optimization of mechanical products.
Framework of Challenges Affecting Adoption of People Analytics in India Using ISM and MICMAC Analysis
Authors: Hota Jyotiranjan
Published: August 2021

People analytics has brought a paradigm shift in the processes, technologies and systems of organizations. Success is driven here through data-driven methodologies. The primary objective of this research is to identify, rank and interrelate challenges affecting the adoption of people analytics in India. The interpretative structural modelling (ISM) approach is applied to rank and interrelate these challenges in the Indian context. MICMAC analysis is conducted to reveal the driving power and dependence of these challenges of people analytics. The MICMAC analysis also indicates the relative importance and interdependence between these challenges in the Indian context. During the first phase of the research, 12 challenges are identified from the literature, and these people analytics challenges are validated based on expert opinions. During the second phase, ISM identifies ‘Leveraging existing enterprise resources’ as the most important challenge in the Indian context among the 11 validated challenges. MICMAC analysis identifies all 11 challenges as ‘linkage challenges’ with high dependence and driving power. For researchers, this methodology facilitates further carrying out exploratory studies and focusing their interactions through hierarchical structures. The study investigates the core issue among many issues faced by people analytics professionals. Second, it has methodological novelty in the context. Finally, it points to multidimensional implications for various stakeholders in people analytics in the Indian context.
A picture of regret: An empirical investigation of post-Brexit referendum survey data
Authors: Collins Alan , Cox Adam , Torrisi Gianpiero
Published: August 2021

Whilst the properties of decision regret have been widely explored in experimental and game theoretic studies, the empirical features of regret from large-scale ‘binary decision’ national events in practice have garnered less scrutiny. This study is an empirical investigation of novel survey data reporting ‘Brexit’ voting choices and expressions of a desire to change voting choices post-referendum. We investigate if Leave voters are more or less likely to express a change to their binary referendum vote choice than those who voted Remain or abstained and then identify the particular characteristics of those who regret their vote choice. A large-scale pan-European survey is used to capture citizens’ perceptions of the European Union containing 17,147 interviews of adults from 15 EU member states. Using responses from UK citizens ( n = 1500), focus is directed to the vote choice for the ‘Brexit’ referendum and the corresponding choice if the referendum were held ‘today’. Probit regression estimation identifies the key differences in the characteristics of those who expressed regret by indicating a desire to change voting choices. Results show that knowledge of EU funding policies, permanence of residential location, population size of the local area, educational attainment, employment status and income are key drivers for regretting the referendum voting decision.
Primary Prostatic Carcinoma With De Novo Diffuse Neuroendocrine Differentiation
Authors: Galea Laurence A. , Mow Christopher , Fine Samson W. , Manohar Paul
Published: August 2021

The 2016 World Health Organization classification of prostate cancer with neuroendocrine (NE) differentiation includes NE cells in usual prostate cancer, adenocarcinoma with Paneth cell-like NE differentiation, well-differentiated NE tumor (carcinoid), small cell NE carcinoma, and large cell NE carcinoma. In this article, we report a rare case of primary prostatic carcinoma with de novo diffuse NE differentiation presenting with bilateral hydronephrosis in a 79-year-old man. This case did not fit into any of the existing classifications. The clinical, radiological, morphological, and immunohistochemical findings and response to androgen deprivation therapy (ADT) are presented. The proposed pathogenesis of NE differentiation via transdifferentiation from conventional prostatic adenocarcinoma whereby genomic alterations, coupled with ADT can induce lineage plasticity resulting in NE differentiation is described.
Adapting, modifying and applying cinematography and editing concepts and techniques to cinematic virtual reality film production
Authors: Zhang Yu , Weber Ian
Published: August 2021

Virtual reality (VR) filmmaking presents a unique cinematic experience requiring new and innovative ways to conceptualise and practice specific aspects of the production process. This article integrates a range of adapted and modified filmmaking thinking, approaches and components into the cinematic virtual reality (CVR) language and grammar in the two critical areas of cinematography and editing. This focus provides a range of possible strategies and tools for would-be VR film directors to engage more efficiently and effectively in VR film production. The article utilises an extended case study of the VR feature film Calling to present the director/editor’s observations and experiences using transmedia journaling and three-dimensional (3D) CVR previsualisation as a simulation tool to create this dynamic, interactive CVR film.
An international hierarchy of science: conquest, cooperation, and the 1959 Antarctic Treaty System
Authors: Yao Joanne
Published: August 2021

The Antarctic Treaty System (ATS), created in 1959 to govern the southern continent, is often lauded as an illustration of science’s potential to inspire peaceful and rational International Relations. This article critically examines this optimistic view of science’s role in international politics by focusing on how science as a global hierarchical structure operated as a gatekeeper to an exclusive Antarctic club. I argue that in the early 20th century, the conduct of science in Antarctica was entwined with global and imperial hierarchies. As what Mattern and Zarakol call a broad hierarchy, science worked both as a civilized marker of international status as well as a social performance that legitimated actors’ imperial interests in Antarctica. The 1959 ATS relied on science as an existing broad hierarchy to enable competing states to achieve a functional bargain and ‘freeze’ sovereignty claims, whilst at the same time institutionalizing and reinforcing the legitimacy of science in maintaining international inequalities. In making this argument, I stress the role of formal international institutions in bridging our analysis of broad and functional hierarchies while also highlighting the importance of scientific hierarchies in constituting the current international order.
Leader group prototypicality and reactions to leader transgressions
Authors: Chang Jin Wook
Published: August 2021

Leader group prototypicality—the extent to which a leader embodies and represents the group—is a characteristic that typically engenders favorable attitudes toward the leader. The present research examines how leader group prototypicality shapes group member reactions to leaders who commit wrongful acts, that is, transgressions. In three studies, I propose and demonstrate that outsiders’ knowledge of leader transgressions moderates how leader group prototypicality influences group member reactions to transgressing leaders. Specifically, when leaders commit transgressions that are known to outsiders, leader group prototypicality leads to more punitive reactions by eliciting an acute threat to the group image. Furthermore, punitive responses against transgressing leaders driven by group image threat are more pronounced among highly identified group members. The current research shows when and why the oft-observed advantage of leader group prototypicality might be reversed.
In search of ‘extra data’: Making tissues flow from personal to personalised medicine
Authors: Pinel Clémence , Svendsen Mette N
Published: August 2021

One of the key features of the contemporary data economy is the widespread circulation of data and its interoperability. Critical data scholars have analysed data repurposing practices and other factors facilitating the travelling of data. While this approach focused on flows provides great potential, in this article we argue that it tends to overlook questions of attachment and belonging. Drawing upon ethnographic fieldwork within a Danish data-linkage infrastructure, and building upon insights from archival science, we discuss the work of data practitioners enabling the repurposing of pathology samples extracted from patients for the conduct of ‘personal medicine’ – our term to discuss the so-called old-fashioned treatment of patients – towards personalised medicine. This first involves ‘getting to know’ the tissues and unpacking their previous uses and meanings, then detaching them from their original source to extract data from such tissues and making them flow towards a new container where they can be worked on and connected with other data. As data practitioners make these tissues travel, transforming them into research data, they organise the attachments of data to new agendas, persons and places. Crucially, in our case, we observe the prominence of national attachments, whereby managing tissues and data in and out of containers involves tying them to the nation to serve its interests. We thus expose how the building of data linkage infrastructures entails more than the accumulation and curation of data, but also involves crafting meanings, futures and belonging to specific communities and territories.
Performance of externally bonded fiber-reinforced polymer retrofits in the 2018 Cook Inlet Earthquake in Anchorage, Alaska
Authors: Tatar Jovan , Sattar Siamak , Goodwin David , Milev Sandra , Ahmed Shafique , Dukes Jazalyn , Segura Christopher
Published: August 2021

As part of the effort to improve the seismic performance of buildings in Alaska (AK), many of the deficient structures in Anchorage, AK, were retrofitted—some with externally bonded fiber-reinforced polymer (EBFRP) composite systems. The 2018 magnitude 7.1 Cook Inlet earthquake that impacted the same region offered an opportunity to evaluate the performance of EBFRP retrofits in a relatively high-intensity earthquake. This study summarizes the following findings of this field investigation: (1) the performance of EBFRP-retrofitted structures in the Cook Inlet earthquake and (2) the observations concerning the condition of FRP retrofits from over a decade of exposure in a subarctic environment. A deployment team from the National Institute of Standards and Technology (NIST) in collaboration with the University of Delaware (UD) Center for Composite Materials conducted post-earthquake inspections of EBFRP retrofits in multiple buildings to assess their performance during the earthquake and condition with respect to weathering. EBFRP debonding was documented with infrared thermography and acoustic sounding and the bond quality between EBFRP and concrete was assessed using pull-off tests. Visual inspections showed no major signs of earthquake damage in the EBFRP-retrofitted components. However, evaluation of debonding and pull-off test results suggested that outdoor conditions may have led to bond deterioration between EBFRP and concrete from installation defects that grew over time, freeze–thaw expansion from moisture present at the FRP/concrete interface, differences in thermal expansion of the materials, or a combination thereof. The carbon fiber–reinforced polymer (CFRP) bond to concrete was found to be more vulnerable to outdoor exposure than the glass fiber–reinforced polymer (GFRP) bond. Earthquake effects on FRP/concrete bond could not be assessed due to the lack of baseline data.
Use of Ophthalmic Sonography to Evaluate for Intraocular Foreign Body in Both Outpatient and Emergency Department/Urgent Care Patients
Authors: Fish Patrick J.
Published: August 2021

Intraocular foreign bodies (IOFB) present differently depending on the type of material (wood, glass, metal) for the IOFB, extent of the injury, and location of the injury. IOFB and the injury can cause a perforation or penetration of the globe which can require more extensive treatment including surgery. Proper evaluation of the IOFB and injury can help to determine extent of the injury, the prognosis of the vision, and health of the eye before and after treatment but may be difficult for the physician depending on the view of the posterior chamber being compromised by media or simply by patient sensitivity. The extent of the injury may also prevent proper evaluation due to swelling, lacerations on the lids, or pain. Proper ophthalmic sonography can provide a quick evaluation of the globe for any IOFB in both the outpatient setting as well as emergency department setting. Evaluation via sonography may allow the physician to accurately diagnose and properly treat the patient to help restore and prevent further loss of vision.
Oberwolfachite, SrFe3+3(AsO4)(SO4)(OH)6, a new alunite-supergroup mineral from the Clara mine, Schwarzwald, Germany and Monterniers mine, Rhône, France
Authors: Chukanov Nikita V. , Möhn Gerhard , Dal Bo Fabrice , Zubkova Natalia V. , Varlamov Dmitry A. , Pekov Igor V. , Jouffret Laurent , Henot Jean-Marc , Chollet Pascal , Vessely Yannick , Friis Henrik , Ksenofontov Dmitry A. , Agakhanov Atali A. , Britvin Sergey N. , Desor Joy , Koshlyakova Natalia N. , Pushcharovsky Dmitry Yu.
Published: August 2021

The new beudantite-group mineral oberwolfachite, ideally SrFe3+3(AsO4)(SO4)(OH)6, was discovered in two localities: Clara mine, Oberwolfach, Schwarzwald, Baden-Württemberg, Germany (holotype) and Monterniers mine, Lantignié, Rhône, Auvergne-Rhône-Alpes, France (cotype). The associated minerals are quartz, baryte, hematite, illite, goethite, beudantite and dussertite (Clara) and arsenogoyazite, jarosite, graulichite-(Ce), goethite and hematite (Monterniers). Oberwolfachite forms yellow to brown platy crystals up to 1 mm across or thick outer zones of mixed (oberwolfachite–beudantite) crystals up to 3 mm across. The lustre is adamantine and the streak is yellow. A distinct cleavage on {0001} is observed. Calculated density is 3.874 g⋅cm–3. The infrared spectra are given. The chemical composition of the holotype/cotype samples are (wt.%, b.d.l. = below detection limit): K2O 1.25/1.86, SrO 6.41/11.15, BaO 8.13/0.45, PbO 2.18/b.d.l., Al2O3 0.16/0.23, Fe2O3 38.99/39.98, La2O3 1.68/not determined, Ce2O3 1.28/2.06, P2O5 0.12/b.d.l., As2O5 17.55/16.55, SO3 12.86/14.99, H2O (calculated) 8.72/9.05, total 99.33/96.62. The empirical formula of the holotype sample is (Sr0.38Ba0.33K0.16Pb0.06La0.06Ce0.05)Σ1.04(Fe3+3.03Al0.02)Σ3.05[(SO4)1.00(AsO4)0.95(PO4)0.01](O6.16H6.00). The crystal structures of both samples were determined using single-crystal X-ray diffraction data and refined to R = 3.13% (holotype, 293 K) and 2.65% (cotype, 170 K). Oberwolfachite is trigonal, R${\bar 3}$m, with a = 7.3270(3) Å, c = 17.0931(9) Å and V = 794.70(8) Å3 (holotype), and a = 7.298(2) Å, c = 16.908(3) Å and V = 779.8(4) Å3 (cotype); Z = 3. The strongest lines of the powder X-ray diffraction pattern of holotype [d, Å (I, %)(hkl)] are: 5.95 (56)(101), 3.664 (37)(110), 3.117 (16)(021), 3.082 (100)(113), 2.548 (15)(024), 2.280 (22)(107), 1.983 (26)(303) and 1.832 (19)(220).
Stage- and sex-specific transcriptome analyses reveal distinctive sensory gene expression patterns in a butterfly
Authors: Ernst David A. , Westerman Erica L.
Published: August 2021

Background

Animal behavior is largely driven by the information that animals are able to extract and process from their environment. However, the function and organization of sensory systems often change throughout ontogeny, particularly in animals that undergo indirect development. As an initial step toward investigating these ontogenetic changes at the molecular level, we characterized the sensory gene repertoire and examined the expression profiles of genes linked to vision and chemosensation in two life stages of an insect that goes through metamorphosis, the butterfly Bicyclus anynana.

Results

Using RNA-seq, we compared gene expression in the heads of late fifth instar larvae and newly eclosed adults that were reared under identical conditions. Over 50 % of all expressed genes were differentially expressed between the two developmental stages, with 4,036 genes upregulated in larval heads and 4,348 genes upregulated in adult heads. In larvae, upregulated vision-related genes were biased toward those involved with eye development, while phototransduction genes dominated the vision genes that were upregulated in adults. Moreover, the majority of the chemosensory genes we identified in the B. anynana genome were differentially expressed between larvae and adults, several of which share homology with genes linked to pheromone detection, host plant recognition, and foraging in other species of Lepidoptera.

Conclusions

These results revealed promising candidates for furthering our understanding of sensory processing and behavior in the disparate developmental stages of butterflies and other animals that undergo metamorphosis.
Economic and disease burden of RSV-associated hospitalizations in young children in France, from 2010 through 2018
Authors: Demont C. , Petrica N. , Bardoulat I. , Duret S. , Watier L. , Chosidow A. , Lorrot M. , Kieffer A. , Lemaitre M.
Published: August 2021

Background

Respiratory syncytial virus (RSV) is the main cause of infant and child hospitalizations. The study objective is to estimate the RSV-associated hospitalizations and economic burden in young children in France to inform future preventive strategies.

Methods

We conducted a retrospective analysis of RSV-associated hospitalizations data from the French Hospital database (PMSI-MCO) which covers the entire French population. All children aged < 5 years hospitalized with RSV ICD-10 codes (J210, J219, J45, J121, J205, R062) from 2010 to 2018, were included. Descriptive analyses were conducted by RSV seasons (Oct to March), by respiratory years (July to June) and per age groups.

Results

On average 50,878 RSV-associated hospitalizations (range: 43,715 – 54,616) per season was reported in France, 69% among children < 1 year old. This represents 28% of all-cause hospitalizations that occurred among children < 1 year old, and less than 10% of all-cause hospitalizations in older children. Number of RSV-associated hospitalizations were similar for infants born during (Oct-March) or outside (April–September) their first RSV season. The highest risk being reported for infants born from September through November. The associated hospitalization cost increased between 2010 - 11 and 2017–18, from €93.2 million to €124.1 million, respectively, and infants < 1 year old represented 80% of the economic burden.

Conclusion

RSV is an important cause of child hospitalization in France. The burden on healthcare system is mainly driven by < 1 year olds, and preventive strategies should be implemented before the first RSV season.
Distinct employment interference profiles in patients with breast cancer prior to and for 12 months following surgery
Authors: Chan Raymond Javan , Cooper Bruce , Gordon Louisa , Hart Nicolas , Tan Chia Jie , Koczwara Bogda , Kober Kord M. , Chan Alexandre , Conley Yvette P. , Paul Steven M. , Miaskowski Christine
Published: August 2021

Purpose

To identify subgroups of female breast cancer patients with distinct self-reported employment interference (EI) profiles and determine which demographic, clinical, and symptom characteristics, and quality of life outcomes were associated with subgroup membership.

Methods

Women with breast cancer (n = 385) were assessed for changes in EI over ten times, from prior to, through 12 months after breast cancer surgery. Latent profile analysis (LPA) was used to identify subgroups of patients with distinct EI profiles.

Results

Three distinct EI profiles (i.e., None – 26.2% (n = 101), Low – 42.6% (n = 164), High – 31.2% (n = 120)) were identified. Compared to the None and Low groups, patients in the High group were more likely to be younger. Higher proportions in the High group were non-White, pre-menopausal prior to surgery, had more advanced stage disease, had received an axillary lymph node dissection, had received neoadjuvant chemotherapy, had received adjuvant chemotherapy, and had a re-excision or mastectomy on the affected breast within 6 months after surgery. In addition, these patients had lower quality of life scores. Compared to the None group, the High group had higher levels of trait and state anxiety, depressive symptoms, fatigue and sleep disturbance and lower levels of cognitive function.

Conclusions

This study provides new knowledge regarding EI profiles among women in the year following breast cancer surgery. The non-modifiable risk factors (e.g., younger age, being non-White, having more advanced stage disease) can inform current screening procedures. The potentially modifiable risk factors can be used to develop interventions to improve employment outcomes of breast cancer patients.