bluuebunny/crossref_metadata_2025 huggingface dataset:
Remote Access to Documents of the Pre-Revolutionary Period of the State Archive of the Irkutsk Region: the Demand and the Prospect of Using the Service
Authors: Mikhaylova Olesya
Published: October 2019

The article deals with the primary legal framework laid down by Emperor Peter I, which determined the order of conducting and streamlining the archival business in tsarist Russia and in Siberia. The author provides the first documentary mentions of the Irkutsk provincial archive as a repository of documents are indicated. Besides it, the legal acts defining the legal basis of the state archival business in Russia and changes in the status of archival bodies and the state archive of the Irkutsk region to the present time are investigated in the article. Moreover, the main indicators of the Department of use of documents and work with citizens and organizations of the state archive of the Irkutsk region were studied, the demand for documents in state storage in the state archive of the Irkutsk region was analyzed, and dysfunctions in the provision of retrospective information by the archive were revealed for the period from 2013 to 2017. The conclusion is made about the need to use remote access services to view documents of the state archive of the Irkutsk region of the pre-revolutionary period. The prospect of introduction of remote access services on a paid basis for users of the information of the state archive of the Irkutsk region is considered and the necessary material and technical conditions for the provision of services at the appropriate level to meet the needs of the information society of the Russian Federation are determined.
Psycho-Semantic Analysis of Students Perceptions of Library Services
Authors: Turganova Gulnara
Published: October 2019

The article is devoted to the problem of studying students ' perceptions of the «library service» using the psychosemantic method. The subject of the study is the semantics of students' perceptions of the university library services. As part of the study, the investigation develops a specialized semantic differential which becomes the basis for the respondents evaluation of the concept "library service". The author carries out a qualitative analysis of the results gained and develops a number of recommendations for introduction to the university library activity. The data obtained during the investigation can be used in organizational activity of the university library in correcting existing services and products in regard to client-biased work in order to increase the students demand for this type of service. In his context, there arises an affect of the level of the users consumption and loyalty through the shaping perception of the library itself in the process of development and introduction of new library services on the basis of the higher educational institution.
Kamuda Geleneksel İntranetten Dijital Çalışma Ortamına Geçiş: TÜİK İntranet Başarı Hikâyesi
Authors: METİN Furkan
Published: October 2019

Bilgi, kamu örgütleri açısından stratejik bir öneme sahip midir? Kamu yöneticilerinin tamamına yakını bu soruya evet yanıtını verecektir. Lakin etkin ve verimli bir biçimde kullanılan yazılı kurumsal hafızaya sahip bir kamu kurumu görebilmek neredeyse imkânsız. Yazılı hale getirilemeyen veya yazılı hale getirilse dahi kişisel bilgisayarlarda hapsolan bilgi notu, sunum, tutanak veya rapor gibi "değerli" bilgiler, çalışanların kurumlardan ayrılması ile birlikte adeta buharlaşıp gitmektedir. Bu vaka çalışmasında süratle dijitalleşmekte olan çalışma ortamlarında, bireyler ve birimler arası etkin ve verimli bir örgütsel e-işbirliği için yeni nesil sosyal İntranet sistemlerine duyulan yüksek gereksinime değinilecektir. Bu kapsamda iş hayatında e-dönüşüm zaruretinin en erken farkına varan kamu kurumlarından biri olan Türkiye İstatistik Kurumu'nda 2012-2017 yılları arasında gerçekleşen İntranet devrimi detaylı bir biçimde incelenecektir. Dijital İntranet sistemleri ile birlikte (a) çalışanların zaman ve mekândan bağımsız olarak e-işbirliği yapabilmesi, (b) iletişim maliyetlerinin düşürülmesi, (c) kurumsal bilişim sistemlerinin İntranet ile entegre edilmesi ve (d) yazılı kurumsal hafıza oluşumunun tohumlarının atılması, gibi süreçlerin nasıl tesis edildiği açıklanmaya çalışılacaktır. Bu çalışma niteliksel bir araştırma olup, veriler gözlem, görüşme ve belge toplama tekniği ile toplanmıştır. Bu çalışma örgütsel e-işbirliği ve sanal uygulama topluluğu yaklaşımlarının Türk Kamu sektöründe hayata geçirilmiş ilk uygulama numunelerinden birini teşkil etmektedir.
Avrupa Komşuluk Politikası’nda Demokrasi Teşviki: Ermenistan Örneği ve İç Dinamiklerin Değerlendirilmesi
Authors: AKGÜL DURAKÇAY Fulya , BOZKAYA Özge
Published: October 2019

Soğuk Savaş’ın sona ermesi ile birlikte uluslararası ilişkilerin güvenlik gündeminin değişmesi ile Avrupa Birliği (AB) 1990’ların sonundan itibaren demokrasiyi teşvik eden uluslararası bir aktör olarak evrilmiştir. AB, Avrupa Komşuluk Politikası’nda demokrasi teşvikini; Birlik normlarının, değerlerinin ve standartlarının komşu ülkelere aktarılması yoluyla güvenlik stratejisi temelinde ele almaktadır. AB’nin demokratikleşme süreçlerinin ülke içi dinamikler ile iç içe olduğunu kabul ettiği demokrasi teşviki politikalarının başarısı, üçüncü ülkelerin istek, irade ve yetkinliklerine bağımlı kalmaktadır. Bu çalışmada, AB’nin demokrasi anlayışı ve demokrasi teşviki politikası Komşuluk Politikası ve Ermenistan örneği üzerinden incelenmektedir. AB’nin Ermenistan ile kurumsal ilişkileri demokrasi teşviki bağlamında tarihsel olarak incelenmekte ve AB’nin koşulluluk ve sosyalleşme mekânizmalarına ne ölçüde başvurduğu analiz edilmektedir. Ermenistan’ın kurumsal yapısı, geleneksel yönetim anlayışı, sivil toplumun gelişmesinin önündeki engeller ve ülkedeki siyasi, iktisadi, sosyal ve askeri Rusya nüfuzu Ermenistan’da demokrasi teşviki sürecindeki AB etkisini belirleyici unsurlar olarak ele alınmaktadır.
Terörizmle Mücadelede Yeni Bir Trend Olarak Terör Örgütleriyle Görüşme Tekniği: PKK/KCK Örneği
Authors: GÜNEŞ Emin
Published: October 2019

Günümüz dünyasında, terör örgütleriyle mücadelede ön plana çıkan müzakere teknikleri ile birlikte müzakere süreçleri, uzun yıllar devam eden öğrenme süreçleri olarak kabul edilmektedirler. Her örgüt kendi içerisinde ayrı karakteristik özellikler taşımakla birlikte, özellikle etnik/bölücü terör örgütleriyle gerçekleştirilen müzakerelerden çıkarılacak sonuçlar atılacak yeni adımlar açısından yol gösterici niteliktedirler. Bu çalışmada müzakere teknikleri SWOT (Strenghts-güçlü yönleri, Weaknesses-zayıf yönleri, Oppurtunities-fırsatlar, Threats-tehditler) analizi çerçevesinde incelenmiş ve neden müzakere tekniklerine müracaat edilmelidir sorusunun cevabı SWOT tablosu ile verilmiştir. Araştırma yöntemi, Türkiye’de gerçekleşen çözüm süreçlerinin mukayeseli analizine ve özellikle IRA ve ETA örnekleriyle karşılaştırmalı analizine dayanmaktadır. Kiminle, ne zaman, nasıl müzakere edilmeli, sorularının yanıtları karşılaştırmalı analize dayalı olarak verilmiştir. Çalışmanın sonuçları, güçlü bir devlet adamı öncülüğündeki müzakerenin; aktörlerinin farklılaştırılması, toplumsal alt yapının sağlanması ve toplumun fikrî olarak bu düşünceye hazırlanması, muhalefetin desteğinin sağlanması halinde başarıya ulaşma ihtimalinin daha yüksek olduğunu göstermektedir. Bu çalışma, doğru ve yanlışlarıyla var olan bir sürecin akademik anlamda incelenerek, daha sonra atılacak adımların daha sağlam atılmasına yol gösterdiği için önem arz etmektedir.
Moustache for All: Do you have? Can you have? A Study of Roles, Stereotype, Crisis of Masculinity and Identity
Authors: Kumar Amit
Published: October 2019

Most people believe in a statement that ‘All men are same’, even most men have taken this thing for granted that at the end they are going to be entitled to the same statement. So most of them hardly try to question the basis of the same. A few men engaged in humanities or social sciences are aware of things otherwise most of the men merely step in this tangled zone of masculinity-femininity or the bigger picture as gender. It has been taken for granted that gender studies mean women studies, homosexuality is not even landed yet, there are no such concepts like masculinity/femininity/gender-inequality etc. Without questioning or inquiring the system, blindly believing later following whatever one has been asking to perform is the current state of role-performance of the society. Forget about gender equality. Still, men are not aware of how their deeds disadvantage their female counterparts. The paper investigates the ways in which sex-roles were assigned/imposed, implied and performed and these sex-roles/stereotypes lead to identity assertion, conflict, violence etc. that results into disadvantaging women from their fundamental rights.
Homofobia y Orientación Sexual en Deportistas Federados en Cataluña: Inmersos en el Legado de la Heteronormatividad
Authors: García-Orriols Jordi , Flix Xavier Torrebadella
Published: October 2019

Nowadays, breaking with sexual diversity discrimination is a social requirement that is increasing. Thus, new theoretical frameworks have been appearing and being discussed but, scarcely, aren’t known by society. Consequently, the heteronormative concept still remains on social contexts, from schools to sport stadiums. In this way, this study is focused on the homophobia grade analysis in different federated sports in Catalonia by the adapted version of Actitudes hacia la Diversidad en el Deporte scale (Piedra, 2016). Moreover, other personal factors (sex, age, sexual orientation) have been considered for the comprehension of this heterosexual masculinity pressure in society, in order to develop future socio-educative proposals to change this scenario.
Caracterização biométrica de frutos, diásporos e sementes de Syagrus coronata (Mart.) Becc
Authors: Moura Sueli da Silva Santos , Gonçalves Edilma Pereira , Moura Mácio Farias de , Viana Jeandson Silva , Lima Amanda de Araújo , Melo Luan Danilo Ferreira de Andrade
Published: October 2019

A espécie S.coronata, mais conhecida como licuri, é uma palmeira ornamental, nativa do Brasil, de grande importância econômica, pois fornece matéria prima para confecção de alimentos, folhas e caules para construção de casas, da amêndoa se extrai um óleo de boa qualidade com potencial para síntese de biodiesel. A caracterização biométrica de frutos e sementes é relevante para o estudo na área de melhoramento genético de populações, para produção de mudas entre outros. Objetivou-se estudar a diversidade genética de frutos, diásporos e sementes de S. coronata por meio da biometria. O trabalho foi realizado no Laboratório de Análise de Sementes - (LAS) da Universidade Federal Rural de Pernambuco/Unidade Acadêmica de Garanhuns-PE, com frutos de licuri coletados na zona rural de Caetés-PE. As avaliações realizadas foram: número de frutos por cacho e por ráquilas, número de ráquilas por cacho, peso média de 100 de frutos e diásporos, peso médio de frutos e diásporos e biometria de frutos, diásporos e sementes. 50% dos cachos de S. coronata analisados possuíam um número de frutos entre 304 a 417 e tendência para uma distribuição normal. Para o número de ráquilas por cacho constatou-se que grande parte das ráquilas foram agrupadas em duas classes com os seguintes intervalos: 35,5-40,40 e 40,5-45,5 mm correspondendo a 40 e 30% das amostras avaliadas, respectivamente. Com relação ao peso médio de 100 frutos e diásporos constatou-se valores médios de 1.056,25g (frutos) e 472,5g (diásporos). As características avaliadas mostraram grande variabilidade genética dentro da população de licuri estudada.
Plant biostimulant on the production of biomass and yield grain of soybean
Authors: Viana Jeandson Silva , Melo João Paulo Ramos de , Silva Júlio César de Almeida , Gonçalves Edilma Pereira , Lima Juliana Joice Pereira , Telino Júnior Wallace Rodrigues
Published: October 2019

Com o crescente interesse na busca de recursos alimentícios que possam substituir parcialmente o uso de concentrados na alimentação animal, o cultivo da soja para a produção de biomassa e grãos responde como uma alternativa para o setor pecuário. Sendo assim, o objetivo desta pesquisa foi testar doses de fitoestimulante e períodos de corte para avaliar o ganho de fitomassa e a produção de grãos de soja na região do Agreste Meridional do estado de Pernambuco, Brasil. O experimento foi realizado em condições de campo, no município de Garanhuns, avaliando-se quatro doses do fitoestimulante (F1= 0,00; F2 = 3,75; F3 = 7,50 e F4 = 11,25 mL kg-1 de sementes) e quatro períodos de corte (C1= sem corte; C2 = 30 DAE; C3 = 35 DAE e C4 = 40 DAE).  A massa seca das plantas foi aumentada com o corte mais tardiamente, o incremento nesse período foi verificado com a aplicação das maiores doses de fitoestimulante, contribuindo na elevação na altura, número de nós e biomassa verde. A dose de fitoestimulante de 7,5 mL kg-1 de semente e o período de corte de 40 dias após a emergência (DAE) são os mais indicados para forragem, por proporcionar maior ganho de biomassa. O corte realizado aos 30 dias associado a dose do fitoestimulante de 4,36 mL kg-1 de sementes proporciona uma maior produção de grãos de rebrota.
Terra Indígena Xukuru-Kariri: avanços e recuos
Authors: Viegas Maria Ester Ferreira da Silva
Published: October 2019

RESUMO: Neste artigo tentaremos abordar como os atores sociais (no caso os Xukuru-Kariri) de Palmeira dos Índios/AL ficaram excluídos do chamado “grande pacto político das elites brasileiras” e como se organizam enquanto grupo para assim fazerem frente aos senhores de terra que, tendo o Estado como garantidor de seu poder econômico, impedem que o campesinato seja ele indígena ou não, perturbe os esquemas da lógica férrea do economicismo desenvolvimentista. A discussão sobre o esfacelamento das terras indígenas no Brasil está no centro das preocupações daqueles que estudam sobre a questão agrária. O debate mais atual demonstra a intensidade e a centralidade da questão agrária no pensamento social e político no Brasil. É certo também que esta discussão reflete muito da conjuntura histórica e econômica do momento em que se contextualiza o discurso e também como se analisam os atores sociais envolvidos dentro do processo agrário brasileiro. O texto ora apresentado discute um momento de construção da emergência de mais uma aldeia do povo Xukuru-Kariri a partir de um movimento de (re) ocupação de terras, liderados então pelo índio Chiquinho Xukuru (índio desaldeado que até então vivia nas periferias da cidade de Palmeira dos Índios) desencadeia um processo de reforço e reformulação de sua identidade étnica, tendo em vista a ampliação de seu espaço político.

PALAVRAS-CHAVES: terra indígena, territorio, demarcação, xukuru-kariri
A utilização do método Pilates no tratamento de escoliose idiopática com pequenos graus de curvatura: uma revisão literária
Authors: Vasconcelos Fabricia Shirley de Oliveira Rodrigues
Published: October 2019

O Método Pilates que foi idealizado pelo alemão Joseph Hubertus Pilates (1880-1967) durante a Primeira Guerra Mundial, inicialmente denominado “Contrologia”, base-se em princípios relacionados às noções de concentração, equilíbrio, percepção, controle corporal, flexibilidade, força e tônus muscular; utilizado hoje para ajudar a amezinhar Escoliose Idiopática. O objetivo deste trabalho é analisar, através de revisões de artigos, se o Método Pilates pode ajudar a amezinhar escolioses idiopáticas com pequenos graus de curvaturas. As pesquisas de caráter de revisões bibliográficas, e estudos de casos e consultas de materiais já publicados por autores que estudaram temas direcionados.  Embora seja evidente a realização de novas pesquisas na área e, com maior quantidade de amostras, o Método Pilates é uma ferramenta comprovadamente útil na reabilitação, melhora na função e na dor causada pela escoliose.

Palavras-chave: Coluna Vertebral; Escoliose; Exercícios Físicos; Método Pilates.
PARASITOSES INTESTINAIS EM PACIENTES ATENDIDOS NO HOSPITAL DAS CLÍNICAS DA FACULDADE DE MEDICINA DE MARÍLIA-SP
Authors: Martins Paulo Sá Filizzola , Castanho Roberto Esteves Pires , Chagas Eduardo Federighi Baisi , Martins Luciamare Perinetti Alves
Published: October 2019

O objetivo desta pesquisa foi verificar a prevalência de enteroparasitoses em pacientes atendidos no Hospital das Clínicas da Faculdade de Medicina de Marília-SP. Desta forma foi realizado um estudo descritivo e analítico, do tipo transversal retrospectivo, com coleta dos dados no Sistema Hospitalar Informatizado do Laboratório de Parasitologia da Faculdade de Medicina de Marília. Entre janeiro de 2012 a dezembro de 2017 foram analisadas 14.343 amostras. Os dados de prevalência foram representados por razão de prevalência e seus respectivos Intervalos de Confiança de 95%. Diferenças significativas entre anos ou faixa etárias foram determinadas pela não intersecção dos limites inferiores e superiores de seus IC95%. Observaram-se 2.149 amostras positivas para parasitas, predominando Blastocystis hominis (10,13%), Giardia lamblia (3,35%) e Strongyloides stercoralis (1,16%). Pode-se inferir que a redução da prevalência das parasitoses é o resultado de políticas públicas pelo uso de medicamentos profiláticos no intuito de interromper a transmissão fecal-oral e não somente pela melhora da infraestrutura sanitária.
AUDITORIA DE UM SERVIÇO DE ATENDIMENTO DE GESTANTES PORTADORAS DE DIABETES MELLITUS GESTACIONAL
Authors: Oliveira Larissa Cano de , Bertoli João Pedro de Paula , Ribeiro e Silva Rodrigo , Ribeiro e Silva Thiago , Souza Matheus Leite Ramos de , Silva Jean Carl
Published: October 2019

Avaliar o tratamento utilizado e a classificação de peso de recém-nascidos (RN) de gestantes portadoras de Diabetes Mellitus Gestacional (DMG). Foi realizado um estudo transversal descritivo com gestantes portadoras de DMG, em gestação única, no período de abril de 2011 a fevereiro de 2016. Os dados avaliados foram o tipo de tratamento utilizado e a classificação de peso do RN. Foram avaliadas 893 gestantes. A dieta e a atividade física como única terapêutica foram utilizadas por 306 (34,3%), 366 (41%) necessitaram metformina, a associação de metformina e insulina foi necessária em 109 (12,2%) e utilizaram somente insulinoterapia 112 (12,5%) gestantes. Houve 27 (3,0%) RN pequenos para a idade gestacional (PIG), 687 (76,9%) RN adequados para a idade gestacional (AIG) e 179 (20,0%) RN grandes para a idade gestacional (GIG). A metformina foi a terapêutica mais utilizada e a maioria dos recém-nascidos foram AIG.
ESTRESSE PERCEBIDO E O USO DE ÁLCOOL, TABACO E OUTRAS DROGAS ENTRE UNIVERSITÁRIOS
Authors: Marquezi Ferro Luiz Roberto , Trigo Alvaro Augusto , Oliveira Aislan José , Ramos de Almeida Marco Aurelio , Fujiko Tagava Regina , Meneses-Gaya Carolina , Rezende Manuel Morgado
Published: October 2019

Avaliar a consumo de drogas em uma população de universitários e verificar as associações com estresse percebido foi o objetivo desta pesquisa. A metodologia utilizada foi de pesquisa descritiva com uma população de 373 universitários. A coleta dos dados se deu de forma online; os participantes responderam ao TCLE, o questionário sociodemográfico, o instrumento para mensurar estresse (escala de Estresse Percebido - EP-10) e consumo abusivo de droga (ASSIST). Para verificar a associação entre o uso abusivo de drogas e a variável estudada foi utilizado o modelo de regressão logística com a significância de p
ASSOCIAÇÃO ENTRE MAUS-TRATOS NA INFÂNCIA E DECLÍNIO COGNITIVO NO IDOSO: UMA REVISÃO INTEGRATIVA
Authors: Pascoal Jr Francisco , Nogueira Guilherme Marcos , Guidolin Bruno Luiz , Cataldo Neto Alfredo
Published: October 2019

A violência contra a criança representa um importante problema de saúde pública, assim como o declínio cognitivo. A ligação entre essas variáveis vem sendo analisada cada vez mais, porque o estresse experimentado nos primeiros anos de vida pode estar relacionado a mudanças estruturais, funcionais e epigenéticas nas regiões cerebrais envolvidas na cognição. O objetivo deste estudo foi analisar essa associação, por meio de uma revisão integrativa da literatura, pelo meio da pesquisa bibliográfica das seguintes bases de dados: SciELO, LILACS, PUBMED e PsycINFO. O período de seleção dos artigos compreendeu os últimos cinco anos. No total, foram 33 artigos, dos quais dez eram artigos originais que focaram na relação entre maus-tratos na infância e declínio cognitivo em idosos. A presença de maus-tratos na infância possui associação com o declínio da função cognitiva no idoso, agravando-o sobremaneira e inclusive podendo colocar os indivíduos em risco de declínio cognitivo acentuado. Uma das limitações deste estudo foi a percepção de que a temática ainda carece de mais e melhores estudos que abordem esta relação na prática, por meio de estudos longitudinais.
Creating a Sense of Community in Distance Education
Authors: STEPHENSON Simon
Published: October 2019

This
study used a qualitative analysis approach to review and organize thematically
the findings of 29 studies related to sense of community in online learning.
The purpose of this paper was to identify what the main themes were in the
literature and to develop some practical applications as a result of the study
as well as suggest some areas for future research. The main themes identified
were the importance of early establishment of behaviours and activities that
facilitate community, the role that the instructor should play, the importance
of developing social presence and social cohesion amongst learners.
Etik Tüketici Davranışı: Marka Odaklı Karar Verme Tarzı ve Demografik Değişkenlere Göre İncelenmesi Üzerine Bir Araştırma
Authors: ÖZDEN Aybike Tuba
Published: October 2019

Tüketici karar verme tarzının faktörlerinden biri olan marka odaklılığı ve etik tüketici davranışı arasındaki ilişki, markaların hedef kitlelerini tanımaları açısından önem taşımaktadır. Nitekim markalar, sadece ürün etiketi olma durumundan uzaklaşarak tüketicilerle ilişki kuran bir kavrama dönüşmektedirler. Etik dışı tüketici davranışı, işletmelerin kârlılığını olumsuz etkilemektedir. Fakat tüketicilerin etik dışı davranmaları, sadece işletmeler için önemli değildir. Tüketicilerin etik davranmaları, toplumsal ahlak açısından da çok mühimdir. Bu nedenle tüketicilerin etik davranışlarının analiz edilmesi ve bu davranışlarına etki eden faktörlerin tespit edilmesi gerekmektedir. Dolayısıyla bu çalışmada, etik tüketici davranışı ve marka odaklı tüketici karar verme tarzı arasındaki ilişkinin araştırılması, işletmelere ve uygulayıcılara öneriler sunarak ilgili literatüre katkı sağlanması amaçlanmaktadır. Bu amaçla, 18 yaş üstü olan toplam 402 tüketiciye anket uygulanmıştır. Elde edilen bulgulara göre, etik tüketici davranışı ile marka odaklı tüketici karar verme tarzı arasında anlamlı ve negatif yönde ilişki olduğu tespit edilmiştir. Araştırmada ayrıca, tüketicilerin etik davranışlarının ve marka odaklı karar verme tarzlarının demografik özelliklerine göre farklılaştığı görülmüştür.
Antimicrobial and antioxidant property of Curcuma longa Linn.
Authors: Muhamed Intan Athirah , Wan Ahmad Wan Amir Nizam , Ramli Nurul Syahida , Ghafar Noraini A.
Published: October 2019

Background: Curcuma longa Linn. (Zingiberaceae family) plant or turmeric is known to possess pharmacological properties at relatively nontoxic doses. The study was carried out with the aim to evaluate the antimicrobial and antioxidant activities of C. longa L.Methods: Ethanolic rhizome extract was applied against Staphylococcus aureus and Salmonella typhi using disc and well diffusion methods. Antioxidant of C. longa L. was determined by measuring 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity.Results: The ethanolic extract of rhizomes showed inhibitory activity against Gram-positive S. aureus bacteria, whereas the Gram-negative S. typhi bacteria were resistant toward the ethanol extract. Zone of inhibitions against S. aureus were 7 mm and 11 mm by disc and well method, respectively. For antioxidant activity, DPPH radical scavenging activity of ethanolic extract of C. longa L. was set against butylated hydroxytoluene (BHT). It was shown that the value of half maximal inhibitory concentration (IC50) of rhizome extract was higher than standard control. The dose response curve was utilized to determine the half maximal IC50 value for each sample. The IC50 of rhizome extract is 21.25 µg/ml, while the value IC50 for BHT is 12.42 µg/ml.Conclusions: The finding suggested turmeric rhizome-extract as a good candidate in the search for a natural antimicrobial and antioxidant agent.
Comparison of efficacy and safety of ketoprofen patch versus diclofenac patch as post-operative analgesic in hysterectomy patients
Authors: Rani Seema , Savant Meenakshi , Mahendru Rajiv , Bansal Pranav
Published: October 2019

Background: The objective of the study was to compare the efficacy and safety of ketoprofen patch versus diclofenac patch as post-operative analgesic in hysterectomy patients.Methods: The study was a prospective, single blind, randomized, comparative interventional clinical study conducted in a tertiary care hospital. Sixty female patients were randomly allocated to receive either ketoprofen or diclofenac patch 1 hour prior to the hysterectomy. Pain was assessed postoperatively after an interval of every four hours for 24 hours using visual analogue scale (VAS) and verbal rating scale (VRS).Results: In ketoprofen group, mean VAS was (2.92±0.11) significantly low as compared to diclofenac group (3.25±0.14). The mean VRS score in group ketoprofen (1.62±0.22) was low as compared to group diclofenac (1.83±0.16). Safety analysis revealed no apparent serious adverse events. Inj. Paracetamol 1 gm i.v was given as rescue analgesic to the patients in whom VRS >2 and VAS >5 was noted. Data were analysed using unpaired student’s t-test.Conclusions: Transdermal patches are very convenient to use and causes less discomfort as compared to traditional routes of drug delivery. Ketoprofen patch was found better in providing analgesia after hysterectomy as compared to diclofenac patch with lesser side effects.
Evaluation of losartan plus hydrochlorothiazide combination therapy against amlodipine monotherapy in patients of hypertension
Authors: Sawant Swati D. , Chawre Sanjeevani M. , Dudhal Kalpana S. , Bansode Amit A.
Published: October 2019

Background: Microalbuminuria has been shown to predict cardiovascular disease (CVD) in patients with hypertension. Recently the FDC of losartan and hydrochlorothiazide (HCTZ) has been reported to be effective for achieving a target BP level and also improvement in cardiovascular prognosis. The present study was conducted to compare effect of losartan plus hydrochlorothiazide combination therapy and high dose amlodipine monotherapy on blood pressure and microalbuminuria.Methods: Total 184 patients with hypertension were randomly allocated to two groups. The patients in group 1 received Amlodipine 5 mg orally for first 4 weeks. The  patients  from  group  2  received  losartan  50  mg  orally  for  first  4  weeks. Patients  in  group  1  were  titrated  to  amlodipine  10  mg  orally  for next 4 weeks. The patients in group 2 were titrated to FDC of losartan (50 mg) plus HCTZ (12.5 mg) for next 4 weeks. Follow–up visits were scheduled at 4 weeks and 8 weeks. Pulse rate, sSBP and sDBP were estimated at each follow–up. Microalbuminuria was estimated at 8 weeks.Results: There was no significant difference in mean change in sSBP, sDBP and pulse rate between two treatment groups (p>0.05). There was greater reduction in microalbuminuria in group 2 patients (p<0.0001). The adverse effects such as flushing and lower extremity oedema were significantly more in amlodipine group (p<0.05).Conclusions: Losartan plus HCTZ has similar effect on BP, better safety profile and superior effect on microalbuminuria level  reduction.
Prescription analysis of hypolipidaemic agents in the department of cardiology in a tertiary care hospital
Authors: Gari Manju , Bansal Megha
Published: October 2019

ABSTRACTBackground: The objective of the present study was to evaluate the prescribing pattern of hypolipidaemic drugs in the outpatient department of cardiology in a tertiary care hospital.Methods: A cross-sectional study was conducted in the department of cardiology for the period of 3 months. A total of 526 prescriptions were analyzed for variants such as the disease patterns, the type of hypolipidaemic drugs which are prescribed for those diseases, the prescribing daily dose of the hypolipidaemic drugs and the prescribing daily dose/daily defined dose ratio of the drugs.Results: On evaluation of the prescriptions, it was conferred that both the patients of normal lipid profile (34.77%) and abnormal lipid profile (65.18%) were prescribed hypolipidaemic drug. Diabetes with hypertension (35.74%) was the most common disease for which hypolipidaemic drugs were prescribed. Atorvastatin (30.98%) was the most common drug which was prescribed as monotherapy, whereas atorvastatin with aspirin and clopidogrel (17.49%) was the most common drug prescribed in combination.Conclusions: Use of statin has become very prevalent with increasing trends of use in both normal and abnormal lipid profile patients, suggesting consideration of rational use of statins to follow good prescribing pattern so that morbidity and mortality can be prevented.
A prospective randomized controlled trial showing efficacy of luteal phase low molecular weight heparin in fresh non-donor IVF/ICSI cycles in women with previous implantation failures
Authors: Singh Neeta , Cheluvaraju Rohitha , Jain Sunesh Kumar
Published: October 2019

Background: Implantation failure is a major challenge in in-vitro fertilization (IVF) cycles. The present study was undertaken to determine the immunomodulatory effects of heparin in patients with previous implantation failures undergoing assisted reproductive techniques (ART).Methods: This was a prospective randomized controlled trial with sample size of 100 patients who had history of at least one previously failed IVF/ICSI. Study group of 50 patients received heparin and 50 patients in control group received routine luteal phase support.Results: Primary outcome of the study was implantation rate (IR) which was 11.03% in the study group was and 5.48% in the control group (p=0.08). Biochemical pregnancy rate and clinical pregnancy rate in the study group was 18% and 12% in the control group (p=0.401). Calculated live birth was 5.15% and 3.42% in the study and control groups respectively (p=0.562). 11 babies were taken home from the study group and 6 from the control group (p=0.18).Conclusions: The result of this pilot study showed relative increase in implantation rates (IR) suggesting beneficial effects of heparin in patients with repeated implantation failures. Although these changes are not statistically significant, the presence of an increasing trend in all the outcome parameters signify the possible benefits of heparin proving for the present study hypothesis.
The role of oral mifepristone in pre-induction cervical ripening at term
Authors: Chourasia Uma H. , Jain Mudita Kamlesh , Fidvi Juzar I.
Published: October 2019

Background: Planned induction of labor is an established part of modern obstetrics and is used as a definite form of treatment where continuation of pregnancy would be detrimental to the health of mother or fetus. The objective of this study was to evaluate the effect of mifepristone in pre-induction cervical ripening and labor induction.Methods: A total of 200 pregnant women at term with Bishop Score 4 or less were selected for this prospective randomized placebo-controlled study. The sample was equally divided into study group to receive 200 mg of mifepristone and control group to receive placebo orally for 2 days. Bishop score was assessed at every 24 hours interval till patient entered in spontaneous labor or 72 hours after 1st dose. Women who did not enter labor spontaneously, labor induction was planned with per vaginal insertion of prostaglandin (PG) E2 analogue, Dinoprostone gel 2.5 mg or PGE1 analogue Tab. Misoprostol 25 µg.Results: Ninety-six subjects in the study group and eighty-one in the control achieved successful ripening of cervix and the difference was statistically significant. Sixty-eight of study group and thirty-nine of placebo group entered in spontaneous active labor within 72 hours. Requirement of oxytocin as adjuvant treatment was significantly lower in the study group. Nineteen women of study group and fifteen of control group delivered within 24 hours, and eighty-one of study group and sixty-two of placebo delivered in 48 hours. The mean induction delivery interval was 35.53±13.67 hours in the study group, whereas it was significantly prolonged in the placebo group 50.49±20.92 hours. Eighty-two subjects of study group and seventy-eight of the control group delivered vaginally, the differences were statistically not significant.Conclusions: Mifepristone was found to be an effective agent for cervical priming prior to labor induction in women at term and significantly reduces the induction delivery interval compared with placebo.
A study to find the correlation between 24-hour urinary protein and spot urinary albumin to creatinine ratio and to determine the accuracy of spot urinary albumin to creatinine ratio as an indicator to detect proteinuria and its use as a rapid alternative test over 24-hour urinary protein in preeclamptic women
Authors: Mahesh Sowmya , Borgohain Deepa
Published: October 2019

Background: Preeclampsia is a multisystem endothelial disease leading to glomeruloendotheliosis with endothelial leak causing significant proteinuria. It is associated with high maternal and fetal risks and fetomaternal morbidity and mortality. Spot urinary albumin to creatinine ratio (ACR) leads to earlier detection of glomerular damage leading to prompt management of preeclamptic patients. To determine the accuracy of Spot Urinary ACR as an indicator to detect proteinuria and its use as a rapid alternative test over 24-hour urinary protein in women with Preeclampsia and to find the correlation between the two.Methods: Spot urinary ACR was measured in 70 consecutive patients with preeclampsia in Assam Medical College, Dibrugarh. The best cut-off value to differentiate between significant and insignificant proteinuria was calculated. The mean, standard deviation and range of various parameters were computed and various statistical tests were used. The Area under the curve and ROC curve were plotted.Results: The best cut-off value to differentiate significant and insignificant proteinuria was calculated as 291.9 mg/g beyond which adverse fetomaternal outcomes and complications were seen. The correlation coefficient between 24-hour urinary protein and spot urinary albumin to creatinine ratio was 0.922 highly significant. The area under the curve was found to be 0.98 with a standard error of 0.0155 which implied that the discriminant ability of spot urinary ACR to differentiate significant proteinuria from insignificant proteinuria in patients with preeclampsia was found to be 98%. Similar studies mentioned in the table below showed a good correlation between 24-hour urinary protein estimation and spot urinary ACR.Conclusions: Compared with 24-hour urinary protein excretion, spot urinary ACR is a simple and accurate indicator of significant proteinuria and helps to detect fetomaternal outcomes in preeclamptic women which may lead to prompt management to reduce fetomaternal complications.
Clinico epidemiological profile of abnormal uterine bleeding in reproductive womens: a cross sectional study
Authors: Singh Neetu , Faruqi Mariyam , Pradeep Yashodhara
Published: October 2019

Background: Abnormal uterine bleeding (AUB) is a common reason for women of all ages to consult their gynecologist and is one of the most common debilitating menstrual problems ending up in hysterectomy in developing countries. This study was done with the aim to observe the clinical and demographic profile of the patients and the pattern of AUB.Methods: It is an observational study, conducted in department of obstetrics and gynaecology, DR Rammanohar Lohia institute of medical sciences, Lucknow, Uttar Pradesh from August 2018 to July 2019. All patients in the reproductive age group with symptoms of abnormal uterine bleeding were included in the study.Results: Majority (37.50%) of the women were in the age group of 30-40 years. 71.66% were multiparous and maximum women (60%) were in normal BMI. 69.17% were belonging to middle class. Commonest presentation was menorrhagia (48.3%) followed by oligomenorrhoea (18.1%) followed by polymenorrhoea (17.27%).Conclusions: Excessive menstrual blood loss is a common reason for women to seek medical help and leads to large demands in health resources According to our study majority of the women with AUB were in the age group of 30-40 years, were multiparous with normal BMI belonging to middle class. Commonest presentation was menorrhagia. Following study highlights the clinical and epidemiological pattern of abnormal uterine bleeding of reproductive age group, which is crucial factor in management for these patients. In order to predict causal association, further more studies with larger sample size of higher level of evidence should be conduct to draw causal evidence.
Analysis of success of vaginal birth after cesarean in relation to indication of primary caesarean section: a tertiary care experience
Authors: Gupta Neha , De Arpita , Gupta Nidhi
Published: October 2019

Background: Apprehensions related to vaginal birth after caesarean (VBAC) has reduced rates of successful vaginal trials over last decade. The objective of this study was to identify the indications of first caesarean section that can lead to a successful trial of labour in subsequent pregnancy.Methods: Retrospective cohort study was done between November 2014 and October 2017. Data from the case records was analysed.Results: Study over 3 years from 2014 to 2017 revealed fetal distress (82.7%),  breech (72.2%), transverse lie (66.7%), antepartum haemorrhage (56.2%) and twins with first non-cephalic (57.9%) have successful outcome of VBAC whereas obstructed labour (19.2%) and failed induction (18.4%) in previous pregnancy have poor outcome for VBAC.Conclusions: Attempts to allow trial of labour after one previous caesarean section with fetal distress, malpresentation and twins as indications of caesarean in previous pregnancy are safe and should be encouraged.
A rare case of conjoined twins presenting as dicephalus parapagus: a case report
Authors: Subburaj Lakshmi , K. Rajkumar
Published: October 2019

Conjoined twinning is a congenital abnormality resulting in various presentations of the fetuses in utero. It is a rare embryological developmental disorder occurring in one in 100,000 births. We present a case of conjoined twinning, which is characterized by the presence of two heads, single vertebral column and single symphysis pubis, with single genitor-urinary tract and single gastro intestinal tract. The present condition, referred to as dicephalus parapagus, is a rare entity among the conjoined twinning and has seldom positive outcomes. The mechanism of occurrence of conjoined twinning has been proposed either through fusion or fission of the embryos. In either case, surgical separation of the conjoined twins is often unsuccessful and results in increased morbidity and mortality. However, it is essential to screen for the presence of such congenital anomalies early during pregnancy, in order to terminate and provide parental counselling.
Study of blood groups and throat swab culture in chronic tonsillitis among pediatric age group
Authors: M. S. Sudhakar Rao , P. Apoorva , K. Keerthi
Published: October 2019

Background: Chronic tonsillitis is a disease of childhood with a peak incidence at 5-6 years of age and the commonest organism being Group A beta hemolytic streptococcus (GABHS). Accurate diagnosis of strep­tococcal infection is essential to limit transmission, reduce the complications and period of communicability. To study the association between blood groups and culture findings of throat swab in chronic tonsillitis among pediatric age group is the aim of our study.

Methods: 60 pediatric patients of clinically diagnosed chronic tonsillitis of both genders who attended outpatient department of otorhinolaryngology and head and neck surgery VIMS, Ballari, Karnataka, India were included in this study on simple random basis. Throat swabs obtained from them were subjected for culture test along with blood grouping and Rh typing.  

Results: In our study, among 60 patients, who presented with recurrent episodes of throat pain for duration of <1 year were 31 (51.7%), of 1-3 years were 15 (25%) and of >3 years were 14 (23.3%). 42 patients (70%) had grade 3 tonsillar enlargement, 14 (23.3%) had grade 2 and 4 (6.7%) had grade 4 tonsillar enlargement. 22 were of B positive blood group (36.7%), 19 of O positive (31.7%), 12 of A positive (20%) and 7 patients of AB positive blood group (11.7%).

Conclusions: Statistically significant association is found among school going age group of both genders infected by the Streptococcal species (p<0.05). Patients of O positive blood group were infected more followed by B positive blood group. 
The effect of iodine in patients using povidone-iodine mouth wash on thyroid function
Authors: Murugesan Gowri Shankar , Venkat Manju Priya
Published: October 2019

Background: Thyroid gland is a key part of endocrine system and it performs its functions via two most important thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroid gland is mainly regulated by thyroid-stimulating hormone (TSH). Povidone-iodine (polyvinylpyrrolidone-iodine, PVP-I) mouthwash is commonly used to treat infections of the oral cavity and oropharynx and iodine released from PVP-I can interfere with thyroid function. In this study the effect of brief treatment with povidone-iodine mouth wash on thyroid function was assessed. The aim of the present study was to assess whether iodine is absorbed through oral transmucosal route and interfere with TSH in serum.

Methods: Fifty one patients with acute and chronic pharyngitis and tonsillitis were recruited and out of which forty-seven patients were treated with 20 ml of PVP-I mouthwash twice daily for 3 weeks and blood was collected from the respective patients before and after treatment with PVP-I. Serum thyroid stimulating hormone concentration was measured from the collected blood samples of the patients.

Results: In the present study there was a small increase in serum TSH concentration during the therapy with PVP-I but the concentration determined was within the normal range.

Conclusions: Based on the results of this study we conclude that the use of PVP-I for a brief period transiently increase TSH value and prolonged use should be avoided in people with an increased risk of thyroid dysfunction and other autoimmune disorders.
Intra-spinal epidural leakage of bone cement during vertebroplasty of an osteoporotic vertebral fracture: case report and review of literature
Authors: Rathod Tushar N. , Shah Kunal A. , Shende Chetan
Published: October 2019

Vertebral fractures are one of the most common complications of osteoporosis. Prolonged and intractable pain leads to immobilization and significant morbidity. Vertebroplasty is designed primarily to relieve pain, and the procedure is considered when osteoporotic vertebral fracture does not respond to a reasonable period of conservative care. Vertebroplasty has a low complication rate with most common complication being adjacent vertebral body fracture and rare complication due to extra-vertebral cement leakage causing nerve root compression or pulmonary embolism. We report a case of 55 year old lady with osteoporotic D12 wedge compression fracture subjected to vertebroplasty resulting in intraspinal cement leakage noticed intra-operatively. Patient underwent immediate decompression, cement extraction and posterior instrumentation. Postoperative course was uneventful.
Kanoniczna ścieżka sygnałowa Wnt
Authors: Kleszcz Robert
Published: October 2019

Kanoniczna ścieżka sygnałowa Wnt fizjologicznie związana jest z regulacją proce­sów embriogenezy, różnicowania komórek i ich proliferacji. W transdukcji sygnału uczestniczy wiele białek, z których najważniejszym mediatorem jest β-katenina. W sta­nie braku pobudzenia ścieżki β-katenina podlega procesowi degradacji proteasomalnej, podczas gdy aktywacja szlaku wiąże się ze wzrostem jej cytoplazmatycznego stężenia i nasileniem translokacji do jądra komórkowego. W wyniku oddziaływania β-kateniny z czynnikami transkrypcyjnymi TCF/LEF dochodzi do zwiększenia ekspresji ponad stu ge­nów docelowych ścieżki Wnt. Nasilenie aktywności kanonicznej ścieżki Wnt obserwuje się w przypadku wielu komórek rakowych, w tym płaskonabłonkowych nowotworów głowy i szyi. Znajomość funkcjonalnej struktury tej ścieżki pozwala z kolei na poszuki­wanie terapeutycznych punktów uchwytu w celu zahamowania aktywności transkryp­cyjnej β-kateniny w komórkach nowotworowych.
Zaćma posteroidowa â polekowe uszkodzenie narządu wzroku, na które warto zwrócić uwagę w terapii nieswoistych chorób zapalnych jelit
Authors: Caban Miłosz
Published: October 2019

Inflammatory bowel diseases (IBD) are a group of diseases which concern an increasing number of patients and are more and more often recognized at a young age. Because of unknown etiology, IBD treatment involves mainly non-specific suppression of inflammatory condition and is based among others on steroids. Glucocorticosteroids display anti-inflammatory action by affecting the course of immune responses, but they also possess several side effects which manifest predominantly during a long-term therapy. These concern, among others the eye and manifest by impaired vision; if left untreated, can lead to blindness. The glucocorticosteroid induced cataract is one of the most common complications of treatment with glucocorticosteroids. In the absence of pharmacological options which have a protective effect, the glucocorÂ­ticosteroid induced cataract is a major problem not only for patients but also clinicians and needs immediate solutions.
The Authority of Honorary Committee of Notary in Obtaining the Copy of Original Deed Owned by Yasmine Citra Maulania
Authors: Maulania Yasmine Citra , Husin Sukanda , Benni Beatrix
Published: October 2019

Honorary Committee of Notary is an institution chosen by the Minister of Justice and Human Rights as the supervisor of Notary position working based on Law Number 2 of 2016 regarding Amendment on Law Number 30 of 2004 regarding Notary Position. In Article 66 of Law of Notary Position, Honorary Committee of Notary basically has authority to give approval on the request of original deed copy. The implementation of this authority is set in the Regulation of Justice and Human Rights Minister Number 7 of 2016 regarding Honorary Committee of Notary.  The validity of this Honorary Committee of Notary automatically gets rejection from some parties if related to judicature. Therefore, the researcher makes research question on how the role of Honorary Committee of Notary in obtaining original deed copy and how the effect of Honorary Committee of Notary consideration towards obtaining copy of original deed. The research method used is judicial normative in which it is an approach done based on primary law material by reviewing theories, concepts, law principles, and regulations regarding to this research. When the copy obtaining is requested to the Honorary Committee of Notary, the members of committee will conduct a meeting. In the meeting, the Public Notary must show his original deed and the members of Honorary Committee of Notary will assess whether it has been in line with the notary protocol or not. If it has been in line with it, the Honorary Committee of Notary deserves to refuse the proposal. This refusal will not be an issue in the assembly because the judicature can run by being supported by other proofs.