bluuebunny/crossref_metadata_2025 huggingface dataset:
Germline Mutational Landscape in Chinese Patients With Advanced Breast Cancer
Authors: Zhang Jiayang , Wang Nan , Zheng Tiantian , Lu Tan , Zhang Ruyan , Ran Ran , Li Kun , Huang Yong , Xie Feng , Zhang Yue , Jia Shidong , Yu Jianjun , Li Huiping
Published: April 2022

Background

Genetic testing for breast cancer (BC) patients may shift the paradigm towards more personalized management and treatment strategies. While gene alterations may be ethnic-specific in breast cancer, our understanding of genetic epidemiology of BC remains mainly driven by data from Caucasian populations and further limited to selected handful of genes.

Methods

We collected whole blood samples from 356 BC patients at metastatic first line BC and primary stage IV disease at Beijing Cancer Hospital between Jan. 2013 to Dec. 2019. A comprehensive 600-gene cancer panel was used to detect germline variants in the covered genes with a median 300x sequencing depth. Variants were classified into pathogenic, likely pathogenic, variant of uncertain significance, likely benign and benign groups according to the ACMG/AMP Standards and Guidelines. Pathogenic and likely pathogenic variants were considered as deleterious mutations.

Results

The median age of 356 BC patients was 49 years (range, 21-87 years) at the first diagnosis of BC. Deleterious germline mutations across 48 cancer-related genes were identified in 21.6% (77/356) of the patients. The most prevalent mutations were BRCA1/2 mutations (7.0%), followed by ATM and RAD50 mutations (1.4% each). In addition, patients with family history were more likely to carry BRCA1 mutations (P=0.04). Moreover, patients with triple-negative breast cancer (TNBC) were more likely to harbor BRCA1 mutations than those with HR+ or HER2+ breast cancer (P=0.006). While there was no significant survival difference observed in BRCA1/2 carriers relative to non-carriers, patients with DNA damage repair (DDR) gene mutations (mostly frequently BRCA, ATM, RAD50) had worse disease-free survival (P=0.02).

Conclusions

The most prevalent germline mutations in a large cohort of Chinese patients with advanced BC were BRCA1/2 mutations, followed by ATM and RAD50 mutations. In total, approximately 16.0% (57/356) of patients carry deleterious mutations in DDR pathway. Patients with breast or ovarian cancer family history were more likely to carry BRCA1/2 mutations, and ones with DDR mutations had worse survival. These findings suggest that DDR mutations are prevalent in Chinese BC patients who may potentially benefit from treatment with Poly (ADP-ribose) polymerase inhibitors.
Fulvestrant May Falsely Increase 17β-Estradiol Levels in Immunoassays: A Case Report of a 57-Year-Old Postmenopausal Patient With Recurrent Estrogen Receptor-Positive Breast Cancer
Authors: Ding Jingxian , Cao Yali , Guo Yonghong
Published: April 2022

The prognosis for female patients with locoregionally recurrent breast cancer has improved with the concurrent local and systemic treatment under multiple disciplinary teams. Radiotherapy is a valuable local treatment measure for unresectable locoregional recurrent breast cancer; however, reirradiation in previously irradiated areas is still a matter of debate. Antihormonal therapy achieves an overall survival benefit for most of these patients with estrogen receptor-positive (ER+) breast cancer in both adjuvant and metastatic settings. Fulvestrant is an ER antagonist and selective ER downregulator widely used in antihormonal therapy, especially in recurrent postmenopausal ER+ breast cancers. However, fulvestrant closely resembles 17β-estradiol in its molecular structure which may result in false increases in serum 17β-estradiol levels in commercially available immunoassays leading to incorrect medical decisions. Herein, we report a case of a 57-year-old postmenopausal patient with recurrent ER+ breast cancer treated with concurrent fulvestrant and reirradiation. There was a good clinical response, and the combination treatment was well tolerable. During the quarterly follow-up, we monitored a gradual increase of the serum 17β-estradiol level in immunoassays, unexpectedly, because the patient underwent natural menopause 8 years ago. To rule out the suspected fulvestrant cross-reactivity with 17β-estradiol in immunoassay, the patient’s serum 17β-estradiol levels were subsequently tested with the more sensitive and specific liquid chromatography-mass spectrometry (LC-MS) method, which confirmed 17β-estradiol levels at the postmenopausal level. Concomitant fulvestrant with reirradiation seems to be a safe and effective therapy for locoregionally recurrent ER+ breast cancer. However, a falsely increased 17β-estradiol may result from cross-reactivity between 17β-estradiol and its molecular analog compounds, for example, fulvestrant. Therefore, it is important for the clinicians with the knowledge of this interaction to prevent unnecessary erroneous interpretation of results and avoid wrong medical decisions.
Racial/Ethnic Differences in Health-Related Quality of Life Among Gay and Bisexual Prostate Cancer Survivors
Authors: Bates Alex J. , Rosser B. R. Simon , Polter Elizabeth J. , Wheldon Christopher W. , Talley Kristine M. C. , Haggart Ryan , Wright Morgan , Mitteldorf Darryl , West William , Ross Michael W. , Konety Badrinath R. , Kohli Nidhi
Published: April 2022

Introduction

Prostate cancer treatment has established effects on the health-related quality of life (HRQOL) of patients. While racial/ethnic differences in HRQOL have been explored in heterosexual patients, this is the first study to examine racial/ethnic differences in a cohort of sexual minority prostate cancer survivors.

Methods

We used data from the Restore-1 study, an online cross-sectional survey of sexual and gender minority (SGM) prostate cancer survivors in North America, to explore the association between race/ethnicity and HRQOL. General mental and physical HRQOL was assessed using the Short-Form Health Survey version 2 (SF-12). The frequency and distress of prostate cancer specific symptoms was assessed using the Expanded Prostate Cancer Composite (EPIC) scale. Multivariable linear regression was used to estimate mean differences in HRQOL between sexual minority men of color and their white, non-Hispanic counterparts after adjustment for pertinent demographic and medical characteristics.

Results

Among 190 participants, 23 (12%) self-identified as non-white and/or Hispanic. In unadjusted analysis, sexual minority men of color compared to their white counterparts reported worse HRQOL scores in the EPIC hormonal summary (73.8 vs. 81.8) and hormonal function (70.9 vs 80.5) domains. Clinically important differences between men of color and their white counterparts were seen in the EPIC bowel function (mean difference (MD): -4.5, 95% CI: -9.9, 0.8), hormonal summary (MD: -8.0, 95% CI: -15.6, -0.4), hormonal function (MD: -9.6, 95% CI: -17.6, -1.6), and hormonal bother (MD: -6.7, 95% CI: -14.4, 1.1) domains. After adjustment for covariates, clinically important differences persisted between men of color and white, non-Hispanic men on the hormonal summary (74.4 vs. 81.7), hormonal function (71.3 vs. 80.3), and hormonal bother (77.0 vs. 82.7) domains.

Conclusions

This exploratory study provides the first evidence that sexual minority men of color may have worse HRQOL outcomes compared to white, non-Hispanic sexual minority men following prostate cancer treatment.
Risk Factors for Unfavorable Pathological Types of Intravesical Recurrence in Patients With Upper Urinary Tract Urothelial Carcinoma Following Radical Nephroureterectomy
Authors: Zhu Jun , Zhang Xiaoqing , Yu Wei , Li Xuesong , He Zhisong , Zhou Liqun , Zhang Zhongyuan , Xiong Gengyan
Published: April 2022

Background

Numerous studies have investigated the risk factors of intravesical recurrence (IVR) after radical nephroureterectomy (RNU) in patients with upper urinary tract urothelial carcinoma (UTUC). However, few studies explore the predictors for unfavorable pathological types of IVR following RNU.

Methods

We retrospectively reviewed 155 patients diagnosed with bladder cancer (BC) following RNU. Binary logistic regression was used for the univariable and multivariable analyses. Nomograms were developed based on the multivariable analysis. The concordance index (C-index) was used to assess the performance of the nomograms. We performed internal validation by generating calibration plots.

Results

Muscle-invasive BC (MIBC) was significantly correlated with operation interval (p = 0.004) and UTUC T-stage (p = 0.016). Operation interval (p = 0.002) and UTUC T-stage (p = 0.028) were also risk factors for BC > 3 cm. UTUC grade (p = 0.015), operation interval (p = 0.003), and hydronephrosis (p = 0.049) were independent predictors for high-grade BC (HGBC). MIBC (p = 0.018) and surgical approach (p = 0.003) were associated with multifocal IVR. Besides, MIBC and HGBC were associated with UTUC grade (p = 0.009), operation interval (p = 0.001), and hydronephrosis (p = 0.023). Moreover, only operation interval (p = 0.036) was a predictor for BC with at least one unfavorable pathological type. We developed nomograms for MIBC, HGBC, BC > 3 cm, and MIBC and/or HGBC. The calibration curves of the nomograms showed good agreement between the observation and prediction cases. The C-indexes of the nomograms were 0.820 (95% CI, 0.747–0.894), 0.728 (95% CI, 0.649–0.809), 0.770 (95% CI, 0.679–0.861), and 0.749 (95% CI, 0.671–0.827), respectively.

Conclusions

The current study found that operation interval, UTUC T-stage, UTUC grade, surgical approach, and hydronephrosis are independent predictors for unfavorable pathological types of IVR following RNU. Nomograms based on these predictors were developed and internally validated to assess the risk of developing unfavorable pathological types of IVR. Furthermore, patients at high risk of developing unfavorable pathological types BC may benefit from more active follow-up 1 year after RNU by early detection of IVR.
Outcomes and Risk Factors of Patients With COVID-19 and Cancer (ONCORONA): Findings from The Philippine CORONA Study
Authors: Espiritu Adrian I. , Larrazabal Ramon B. , Sy Marie Charmaine C. , Villanueva Emilio Q. , Anlacan Veeda Michelle M. , Jamora Roland Dominic G.
Published: April 2022

Background

A study conducted in China on patients with coronavirus disease 2019 (COVID-19) showed that cancer conferred a five times increased risk for needing intensive care admission and mortality; No data has yet been collected and published from the Philippines. Thus, the investigators conducted this substudy to determine the association of having a history of cancer with clinical outcomes among patients included in the Philippine CORONA Study.

Methodology

Multi-center, retrospective cohort design

Results

A total of 244 patients had a history of cancer, out of 10,881 COVID-19 hospital admissions. After adjusting for different confounding variables of interest, having cancer was significantly associated with a 75% increased odds of having severe/critical COVID-19 at nadir (CI 95% 1.32, 2.33; p < 0.001). After adjusting for different confounding variables of interest, having cancer was significantly associated with the following time-to-event outcomes: 72% increase in hazard of in-hospital mortality (CI 95% 1.37, 2.16; p < 0.001), 65% increase in hazard of respiratory failure (CI 95% 1.31, 2.08; p < 0.001), and 57% increase in hazard of being admitted to ICU (CI 95% 1.24, 1.97; p < 0.001).

Conclusion

A history of cancer conferred poorer clinical outcomes on adult, hospitalized COVID-19 patients.
Imaging Biomarkers in Prostate Stereotactic Body Radiotherapy: A Review and Clinical Trial Protocol
Authors: Liu Wei , Loblaw Andrew , Laidley David , Fakir Hatim , Mendez Lucas , Davidson Melanie , Kassam Zahra , Lee Ting-Yim , Ward Aaron , Thiessen Jonathan , Bayani Jane , Conyngham John , Bailey Laura , Andrews Joseph D. , Bauman Glenn
Published: April 2022

Advances in imaging have changed prostate radiotherapy through improved biochemical control from focal boost and improved detection of recurrence. These advances are reviewed in the context of prostate stereotactic body radiation therapy (SBRT) and the ARGOS/CLIMBER trial protocol. ARGOS/CLIMBER will evaluate 1) the safety and feasibility of SBRT with focal boost guided by multiparametric MRI (mpMRI) and 18F-PSMA-1007 PET and 2) imaging and laboratory biomarkers for response to SBRT. To date, response to prostate SBRT is most commonly evaluated using the Phoenix Criteria for biochemical failure. The drawbacks of this approach include lack of lesion identification, a high false-positive rate, and delay in identifying treatment failure. Patients in ARGOS/CLIMBER will receive dynamic 18F-PSMA-1007 PET and mpMRI prior to SBRT for treatment planning and at 6 and 24 months after SBRT to assess response. Imaging findings will be correlated with prostate-specific antigen (PSA) and biopsy results, with the goal of early, non-invasive, and accurate identification of treatment failure.
Glycosylated Cathepsin V Serves as a Prognostic Marker in Lung Cancer
Authors: Yang Lewei , Zeng Qi , Deng Yun , Qiu Yeqing , Yao Wei , Liao Yifeng
Published: April 2022

Dysregulation of cysteine cathepsin protease activity is pivotal in tumorigenic transformation. However, the role of cathepsin protease in lung cancer remains unknown. Here, we analyzed GEO database and found that lung cancer presented high expression of cathepsin V (CTSV). We then performed immunohistochemistry assay in 73 paired lung cancer tissues and normal lung tissues and confirmed that CTSV is overexpressed in lung cancer and correlates with poor prognosis. The mass spectrometry experiment showed that the N-glycosylation locus of CTSV are N221 and N292, glycosylated CTSV (band 43 kDa) was particularly expressed in lung cancer samples and correlated with lymph node metastasis. Mechanistic studies showed that only glycosylated CTSV (43-kDa band) are secreted to extracellular matrix (ECM) and promoted the metastasis of lung cancer. Importantly, the Elisa detection in serum of 12 lung cancer patients and 12 healthy donors showed that the level of CTSV in serum distinguished lung cancer patients from healthy donors. Together, our findings reveal the clinical relevance of CTSV glycosylation and CTSV drives the metastasis of lung cancer, suggesting that the glycosylated CTSV in serum is a promising biomarker for lung cancer.
Silencing circOMA1 Inhibits Osteosarcoma Progression by Sponging miR-1294 to Regulate c-Myc Expression
Authors: Shi Yubo , Tian Yunyun , Sun Xiangran , Qiu Yonglong , Zhao Yingchun
Published: April 2022

Background

Several studies have reported that circRNAs have a crucial function in the tumorigenesis of various cancers. However, the expression and function of circOMA1 in osteosarcoma is unknown.

Methods

circOMA1 was identified through bioinformatics analysis. qRT-PCR was used to assess the expressions of circOMA1, miR-1294, and c-Myc in osteosarcoma tissues. Further, we performed functional experiments to explore the biological function of circOMA1 in osteosarcoma. Moreover, a luciferase reporter assay, RNA immunoprecipitation (RIP), and fluorescence in situ hybridisation (FISH) assay were performed to demonstrate the association between circOMA1 and miR-1294.

Results

circOMA1 exhibited considerable upregulation in osteosarcoma tissues compared with adjacent normal tissues. Silencing circOMA1 suppressed osteosarcoma progression in vitro and in vivo. Mechanically, circOMA1 functioned as a sponge of miR-1294 to upregulate c-Myc expression.

Conclusion

circOMA1 played the role of an oncogene in osteosarcoma and promoted osteosarcoma progression by mediating the miR-1294/c-Myc pathway, which might be a new target for treating osteosarcoma.
Pediatric Intestinal Pseudo-Obstruction: Progress and Challenges
Authors: Turcotte Marie-Catherine , Faure Christophe
Published: April 2022

Background

Chronic intestinal pseudo-obstruction is a rare disorder and represents the most severe form of gastrointestinal dysmotility with significant morbidity and mortality. Emerging research shows considerable differences between the adult and pediatric population with intestinal pseudo-obstruction and the term Pediatric Intestinal Pseudo-Obstruction (PIPO) was recently proposed.

Purpose

The aim of this article is to provide pediatric gastroenterologists and pediatricians with an up to date review of the etiology and underlining pathophysiology, clinical features, diagnostic and management approaches currently available for PIPO and to discuss future perspectives for the diagnosis and management of this rare disease.
An Update on Childhood-Onset Takayasu Arteritis
Authors: Aeschlimann Florence A. , Yeung Rae S. M. , Laxer Ronald M.
Published: April 2022

Takayasu Arteritis (TAK) is a rare large vessel vasculitis affecting the aorta and its major branches. The heterogeneous and often severe clinical manifestations result from systemic and local inflammation as well as end-organ ischemia. Disease flares are common and contribute to accrued damage over time with significant morbidity and mortality. Newer understanding of the pathogenesis in TAK has paved the way for the use of pathway targeting agents such as tumor necrosis factor (TNF)α- or interleuking (IL)-6-inhibitors with improved disease control. Nevertheless, long-term data are lacking, particularly in children; prognosis often remains guarded and the disease burden high. This article aims at providing a comprehensive review of childhood-onset TAK with a focus on recent publications.
Thioredoxin-1 Activation by Pterostilbene Protects Against Doxorubicin-Induced Hepatotoxicity via Inhibiting the NLRP3 Inflammasome
Authors: Tan Shiqing , Bai Jie , Xu Mingxi , Zhang Longying , Wang Ying
Published: April 2022

Background: Doxorubicin (DOX) has been widely used in cancer treatment. However, DOX can cause a range of significant side effects, of which hepatotoxicity is a common one, and therefore limits its clinical use. Pterostilbene (PTS) has been shown to exhibit anti-oxidant and anti-inflammatory effects in the treatment of liver diseases but whether PTS could protect against hepatotoxicity in DOX-treated mice is unknown.

Methods: In our study, we use C57/BL6J mice and the HepG2 cell line. We divided the mice in 4 groups: the control, the PTS treatment, the DOX treatment, and the DOX + PTS treatment group. Liver histopathology was judged by performing hematoxylin–eosin and Masson staining. Immunohistochemistry was used to perform the expression of NLRP3. The levels of serum alanine transaminase (ALT) and aspartate transaminase (AST) were evaluated. Levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), and DCFH-DA staining were used to evaluate the oxidative injury. Western blot and real-time PCR were applied to evaluate the expressions of proteins and mRNA. MTT was used to evaluate DOX-induced cell injury and the protective effects of PTS. Recombinant Trx-1 was used to analyze the mechanism of PTS. A TUNEL assay was used to detect apoptosis in DOX-induced HepG2 cells and the protective effects of PTS.

Results: PTS ameliorated DOX-induced liver pathological changes and the levels of AST and ALT. PTS also decreased the level of MDA, increased the level of SOD, GSH, and the expression of Trx-1 in DOX-treated mice. PTS decreased the levels of NLRP3 and IL-1β mRNA and the expressions of their proteins in DOX-treated mice. In addition, PTS also decreased the expression of Cleaved Caspase-3 and BAX and increased the expression of BCL-2. In vitro, after treatment with recombinant Trx-1, ROS and NLRP3 inflammasome were both decreased. Treatment with PTS could rescue the downregulation of Trx-1, decreased the ROS level and the NLRP3 inflammasome, and protected HepG2 cells against DOX-induced apoptosis.

Conclusion: The results show that PTS exhibits protective effects against DOX-induced liver injuries via suppression of oxidative stress, fibrosis, NLRP3 inflammasome stimulation, and cell apoptosis which might lead to a new approach of preventing DOX-induced hepatotoxicity.
Multidimensional Discrete Chaotic Maps
Authors: Bucolo Maide , Buscarino Arturo , Fortuna Luigi , Gagliano Salvina
Published: April 2022

In this paper, the general concept of multidimensional discrete maps is presented. Moreover, new and fundamental results show the invariance of the bifurcation points from periodic to chaotic behavior. Numerical examples regarding the multidimensional cases of the logistic map, the complex-valued Ikeda map, and the multivariable Henon map are reported.
The Spillover Effect and Dynamic Correlation of the China-US Bean Futures Markets Based on Investor Sentiment
Authors: Wu Binghui , Wang Ting
Published: April 2022

This study analyzes the spillover effect and dynamic correlation of the China-US bean futures markets and discusses the relationship between the dynamic correlation of the bean futures price index and investor sentiment. First, the spillover effect of the China-US bean futures markets is analyzed through the BEKK-GARCH model. Then, the DCC-GARCH model is used for obtaining the dynamic correlation coefficients of the China-US bean futures markets. Next, the principal component analysis method is chosen to construct a comprehensive investor sentiment index. Lastly, the dynamic impacts between the change in investor sentiment and the correlation of the China-US bean futures price index are discussed through the ensemble empirical mode decomposition and impulse response analysis. The results show that the spillover effect of different degrees and directions exists between the China-US bean futures markets, and the dynamic correlation coefficients among different bean futures are also different. Besides, a certain degree of interactions exists between the high-frequency and low-frequency components of the comprehensive investor sentiment index and the dynamic correlations of bean futures price indexes.
Methods for the Cost-Effective Production of Bacteria-Derived Double-Stranded RNA for in vitro Knockdown Studies
Authors: Verdonckt Thomas-Wolf , Vanden Broeck Jozef
Published: April 2022

RNA interference (RNAi) is a highly conserved pathway for the post-transcriptional regulation of gene expression. It has become a crucial tool in life science research, with promising potential for pest-management applications. To induce an RNAi response, long double-stranded RNA (dsRNA) sequences specific to the target gene must be delivered to the cells. This dsRNA substrate is then processed to small RNA (sRNA) fragments that direct the silencing response. A major obstacle to applying this technique is the need to produce sufficiently large amounts of dsRNA in a very cost-effective manner. To overcome this issue, much attention has been given to the development and optimization of biological production systems. One such system is the E. coli HT115 strain transformed with the L4440 vector. While its effectiveness at inducing knockdowns in animals through feeding of the bacteria has been demonstrated, there is only limited knowledge on the applicability of bacteria-derived dsRNA for in vitro experiments. In this paper, we describe and compare methods for the economical (43.2 €/mg) and large-scale (mg range) production of high-quality dsRNA from the HT115 bacterial system. We transformed the bacteria with constructs targeting the Helicoverpa-specific gene Dicer2 and, as a non-endogenous control, the Green Fluorescent Protein gene (GFP). First, we compared the total RNA extraction yields of four cell-lysis treatments: heating, lysozyme digestion, sonication, and a control protocol. Second, we assessed the quality and purity of these extracted dsRNAs. Third, we compared methods for the further purification of dsRNAs from crude RNA extracts. Finally, we demonstrated the efficiency of the produced dsRNAs at inducing knockdowns in a lepidopteran cell line. The insights and results from this paper will empower researchers to conduct otherwise prohibitively expensive knockdown studies, and greatly reduce the production times of routinely or large-scale utilized dsRNA substrates.
Cardiac Autonomic Modulation and Response to Sub-Maximal Exercise in Chilean Hypertensive Miners
Authors: Lang Morin , Mendt Stefan , Paéz Valeria , Gunga Hanns-Christian, , Bilo Grzegorz , Merati Giampiero , Parati Gianfranco , Maggioni Martina Anna
Published: April 2022

Cardiac autonomic modulation in workers exposed to chronic intermittent hypoxia (CIH) has been poorly studied, especially considering hypertensive ones. Heart rate variability (HRV) has been proven as valuable tool to assess cardiac autonomic modulation under different conditions. The aim of this study is to investigate the cardiac autonomic response related to submaximal exercise (i.e., six-minute walk test, 6MWT) in hypertensive (HT, n = 9) and non-hypertensive (NT, n = 10) workers exposed for > 2 years to CIH. Participants worked on 7-on 7-off days shift between high altitude (HA: > 4.200 m asl) and sea level (SL: < 500 m asl). Data were recorded with electrocardiography (ECG) at morning upon awakening (10 min supine, baseline), then at rest before and after (5 min sitting, pre and post) the 6MWT, performed respectively on the first day of their work shift at HA, and after the second day of SL sojourn. Heart rate was higher at HA in both groups for each measurement (p < 0.01). Parasympathetic indices of HRV were lower in both groups at HA, either in time domain (RMSSD, p < 0.01) and in frequency domain (log HF, p < 0.01), independently from measurement’s time. HRV indices in non-linear domain supported the decrease of vagal tone at HA and showed a reduced signal’s complexity. ECG derived respiration frequency (EDR) was higher at HA in both groups (p < 0.01) with interaction group x altitude (p = 0.012), i.e., higher EDR in HT with respect to NT. No significant difference was found in 6MWT distance regarding altitude for both groups, whereas HT covered a shorter 6MWT distance compared to NT (p < 0.05), both at HA and SL. Besides, conventional arm-cuff blood pressure and oxygen blood saturation values (recorded before, at the end and after 5-min recovery from 6MWT), reported differences related to HA only. HA is the main factor affecting cardiac autonomic modulation, independently from hypertension. However, presence of hypertension was associated with a reduced physical performance independently from altitude, and with higher respiratory frequency at HA.
An Exploration of How Biophilic Attributes on Campuses Might Support Student Connectedness to Nature, Others, and Self
Authors: Alves Susana , Betrabet Gulwadi Gowri , Nilsson Pia
Published: April 2022

University Campuses remain important settings for nurturing and supporting student health and quality of life (QoL). Research shows the health benefits of nature experiences may be facilitated by campus spaces and activities that afford connectedness. Connectedness to nature, others, and self may allow students to cope with mental fatigue, stress, and a constant need for restoration. Despite recent encouraging trends, we still lack an integrative conceptual framework to describe the mechanisms involved in achieving connectedness for making recommendations for campus design. In this conceptual review, we examine students’ connectedness in campus settings in relation to biophilic elements and attributes. We aim to understand how both direct and indirect pursuits in nature and also place-based experiences on campus foster connectedness and consequently impact students’ health and QoL. Our analysis shows that connectedness seen through the lens of Kellert’s biophilic design principles and aided by Alexander’s pattern language provides a relational and long-term perspective on recommending strategies for connecting students to nature, to others, and to themselves in campus settings.
Comparing Students of Medical and Social Sciences in Terms of Self-Assessment of Perceived Stress, Quality of Life, and Personal Characteristics
Authors: Wielewska Magda K. , Godzwon Julia M. , Gargul Kacper , Nawrocka Emma , Konopka Kinga , Sobczak Krzysztof , Rudnik Agata , Zdun-Ryzewska Agata
Published: April 2022

The aim of this study was to compare medical and social sciences students’ outcomes in terms of self-perceived stress, quality of life, and personality traits. We put particular emphasis on external and internal differences in students of specific fields–medicine, nursing, psychology, and pedagogy. In a survey, 1,783 students from Medical University of Gdańsk and University of Gdańsk participated in our study, of whom 1,223 were included in the final statistical analysis. All of them were evaluated using valid and reliable questionnaires–TIPI-PL, PSS-10, and a one-item scale of quality of life. Stress turned out to have a negative effect on quality of life, regardless of the type of field of study. Moreover, students from different fields varied in terms of personality factors: conscientiousness, agreeableness, openness to experience, and emotional stability. In conclusion, many students regardless of their field suffer from high stress and report low quality of life, which potentially further affects their academic performance and social life.
Emotion Analysis of Cross-Media Writing Text in the Context of Big Data
Authors: Ren Rui
Published: April 2022

Since the beginning of the 21st century, sentiment analysis has been one of the most active research fields in natural language processing. Now sentiment analysis technology has not only achieved significant results in academia, but also has been widely used in practice. From business services to political campaigns, sentiment analysis is used in more and more fields. Sentiment analysis is essentially to dig out the user’s emotional attitude from the massive emotional natural language text data, and analyze the emotional dynamics of the text author through certain technical means. At present, there is almost no sentiment analysis in cross-media writing content, and it can rarely help cross-media writing vision to advance with the times and comprehensive improvement of writing ability to adapt to the current rapidly developing information society; the commonly used text media in the digital age are not. Then there is the only composition tool. Various new media appearing with the development of the ages continue to intervene in writing, and it is the general trend to cultivate media literacy in writing. The main content of this paper is the research on the emotional intensity of students’ Internet public Aiming at the shortcomings of the topic feature word selection in the sentiment tendency analysis of the students’ Internet public opinion, improvements have been made to facilitate the research on the sentiment intensity of the sentiment analysis of the students’ Internet public opinion. Sentiment analysis of students’ cross-media written text through an improved MapReduce combinator model.
Exploring the Modus Operandi of Coaches Who Perpetrated Sex Offenses in Canada
Authors: St-Pierre Elisabeth , Parent Sylvie , Deslauriers-Varin Nadine
Published: April 2022

This study investigated the modus operandi strategies employed by 120 coaches who committed sexual abuse toward 331 athletes under their authority. More than 2,000 Canadian court judgements and media reports were identified using online search databases. Using descriptive analysis, 51 strategies used in six modus operandi stages were identified. Results highlighted the most frequent strategies used by coaches for each stage of the crime commission process. Additionally, findings revealed the influence of the victims' gender, coaches' sport level and year of coaches' first offenses on modus operandi strategies used. Implications for crime prevention measures are discussed.
Changes in Prevalence and Severity of Domestic Violence During the COVID-19 Pandemic: A Systematic Review
Authors: Thiel Freya , Büechl Verena C. S. , Rehberg Franciska , Mojahed Amera , Daniels Judith K. , Schellong Julia , Garthus-Niegel Susan
Published: April 2022

Background

To contain the spread of COVID-19, governmental measures were implemented in many countries. Initial evidence suggests that women and men experience increased anger and aggression during COVID-19 lockdowns. Not surprisingly, media reports and initial empirical evidence highlight an increased risk for domestic violence (DV) during the pandemic. Nonetheless, a systematic review of studies utilizing participants' reports of potential changes in DV prevalence and severity during the pandemic as compared to pre-pandemic times is needed.

Objective

To examine empirical, peer-reviewed studies, pertaining to the potential change in prevalence and severity of different types of DV during the COVID-19 pandemic, as reported by study participants.

Data Sources

Electronic EMBASE, MEDLINE, PsycINFO, and CINAHL searches were conducted for the period between 2020 and January 5, 2022. References of eligible studies were integrated by using a snowballing technique.

Study Selection

A total of 22 primary, empirical, peer-reviewed studies published in English or German were included.

Results

Of the 22 studies, 19 were cross-sectional whereas 3 included both pre-pandemic and during pandemic assessments. Data synthesis indicates that severity of all types of DV as well as the prevalence of psychological/emotional and sexual DV increased for a significant number of victims in the general population during the pandemic. Evidence for changes in prevalence regarding economic/financial, physical, and overall DV remains inconclusive. There was considerable between-study variation in reported prevalence depending on region, sample size, assessment time, and measure.

Conclusions

Data synthesis partly supports the previously documented increase in DV. Governmental measures should consider the availability of easily accessible, anonymous resources. Awareness and knowledge regarding DV need to be distributed to improve resources and clinical interventions.
Causes of Missed Nursing Care During COVID-19 Pandemic: A Qualitative Study in Iran
Authors: Safdari Ali , Rassouli Maryam , Jafarizadeh Raana , Khademi Fatemeh , Barasteh Salman
Published: April 2022

Background

The unpredictable and variable nature of COVID-19 and the lack of healthcare resources has led to inadequate care for patients. This study aimed to explain the causes of missed nursing care during the COVID-19 pandemic from the perspective of Iranian nurses.

Method

This qualitative study was conducted using semi-structured interviews with 14 nurses caring for patients with COVID-19 in three hospitals in Iran. Sampling was performed by the purposive method. Data were analyzed using the conventional content analysis method. The interviews were first recorded and transcribed, and then the data were analyzed using the Elo and Kyngas method. Data management was done with MAXQDA software version 10. To achieve trustworthiness, the criteria presented by Lincoln and Guba were used.

Findings

A total of 14 nurses participated in the study. The mean age of participants was 31.85 ± 4.95 years, and the mean number of years of work experience was 7.71 ± 4.44. Eleven participants were women. Among all participants, nine had a bachelor's degree and five had a master's degree. Four nurses had fixed shifts, while ten nurses had rotating shifts. The causes of missed nursing care were categorized into 4 groups. The category “unfulfilled care” comprised the reasons for forgetting care, neglecting care, arbitrary elimination of care, and compulsory elimination of care. The category of “care at improper time” consisted of interference of the care in patients' daily activities and interference with other healthcare providers' activities. The “incomplete cares” category comprised failure to complete the care period in hospital, interruption in care, and discontinuance of care after patient discharge. The last category, “incorrect care,” consisted of providing care regardless of the nursing process, providing care by unqualified professionals, and providing trial-and-error care.

Conclusion

This study illustrates an understanding of the causes of missed nursing care during the COVID-19 pandemic from the perspective of nurses. The increasing demand for care caused by the pandemic and problems in the work environment has led to the failure of nurses to provide complete, correct care and sometimes miss parts of care to patients. Therefore, nursing policymakers and managers should develop and implement appropriate care protocols and instructions to minimize missed nursing care.
A Transfer Learning Method for Detecting Alzheimer's Disease Based on Speech and Natural Language Processing
Authors: Liu Ning , Luo Kexue , Yuan Zhenming , Chen Yan
Published: April 2022

Alzheimer's disease (AD) is a neurodegenerative disease that is difficult to be detected using convenient and reliable methods. The language change in patients with AD is an important signal of their cognitive status, which potentially helps in early diagnosis. In this study, we developed a transfer learning model based on speech and natural language processing (NLP) technology for the early diagnosis of AD. The lack of large datasets limits the use of complex neural network models without feature engineering, while transfer learning can effectively solve this problem. The transfer learning model is firstly pre-trained on large text datasets to get the pre-trained language model, and then, based on such a model, an AD classification model is performed on small training sets. Concretely, a distilled bidirectional encoder representation (distilBert) embedding, combined with a logistic regression classifier, is used to distinguish AD from normal controls. The model experiment was evaluated on Alzheimer's dementia recognition through spontaneous speech datasets in 2020, including the balanced 78 healthy controls (HC) and 78 patients with AD. The accuracy of the proposed model is 0.88, which is almost equivalent to the champion score in the challenge and a considerable improvement over the baseline of 75% established by organizers of the challenge. As a result, the transfer learning method in this study improves AD prediction, which does not only reduces the need for feature engineering but also addresses the lack of sufficiently large datasets.
Medical Device Product Innovation Choices in Asia: An Empirical Analysis Based on Product Space
Authors: Hu Feng , Qiu Liping , Zhou Haiyan
Published: April 2022

Due to the increasing demand for health care, identifying and evaluating the feasibility of local medical device innovation and production is an important guarantee for the long-term sustainable development of a national health system, especially for Asian countries/regions that are plagued by aging populations. This article analyzes the international trade data of 46 HS 6-digit medical device products exported from 49 countries from 1999 to 2019, and constructs a global medical device product space. Furthermore, the innovation potential and opportunities of potential medical device products in major Asian countries are evaluated by examining the dynamic relationship between the product distance and the acquisition of comparative advantages for medical device products based on an empirical model. The regression results suggest that a close product distance improves the feasibility of developing a new medical device product. The smaller the product distance is, the more likely it is to increase the diversity of the medical device products of a country by maintaining the existing comparative advantages and gaining potential comparative advantages. Furthermore, we follow the conclusions of the empirical model and analyze the product space evolution, and potential product distance and gains of major Asian medical device exporters. These conclusions may help entrepreneurs identify potential development directions and help government policy-makers formulate policies that are in line with national realities.
AI Technologies, Privacy, and Security
Authors: Elliott David , Soifer Eldon
Published: April 2022

Privacy remains one of the most recurrent concerns that people have about AI technologies. The meaning of the concept of “privacy” has proven to be fairly elusive. Accordingly, the concerns people have about privacy are often vague and ill-formed, which makes it correspondingly difficult to address these concerns, and to explain the ways in which AI technologies do or do not pose threats to people's interests. In this article, we draw attention to some important distinctions that are frequently overlooked, and spell out their implications for concerns about the threats that AI-related technology poses for privacy. We argue that, when people express concerns about privacy in relation to AI technologies, they are usually referring to security interests rather than interests in privacy per se. Nevertheless, we argue that focusing primarily on security interests misses the importance that interests in privacy per se have through their contribution to autonomy and the development of our identities. Improving insight about these issues can make it easier for the developers of AI technologies to provide explanations for users about what interests are and are not at stake through the use of AI systems.
Characterizing Competing Viewpoints in Stormwater Governance: An Urban Honolulu Case Study
Authors: Arik Aida D.
Published: April 2022

Stormwater management is a fundamental public service in urban areas that has wide-ranging implications on water supply, public safety, and ecosystem health. This paper examines stormwater management priorities expressed by community leaders and residents, educators, industry professionals, and water managers. It uses Q-methodology, a mixed-method approach, to understand prevalent narratives around stormwater management that comprise the public discourse. The purpose of this research is to elucidate points of agreement and disagreement in the context of a contentious flood risk management project. In total, 18 participants ranked an identical set of 25 idea statements relative to one another. Through principal component analysis, I identify four distinct narratives that prioritize different aspects of stormwater management objectives. The narrative analysis shows broad agreement that decentralized, soft infrastructure (e.g., green infrastructure) should be part of stormwater management solutions. However, there is widespread disagreement over funding mechanisms, the community's responsibilities, and the underlying planning approach to stormwater management. There was no discernable pattern in sector affiliation with any of the narratives. I summarize the dimensionality of stormwater governance and the potential spectrum of ideas about infrastructure, responsibilities, and planning approaches in a framework that characterizes competing viewpoints. The results of this study are useful in understanding underlying sources of conflict regarding stormwater management that may not be readily apparent in public discourse.
Empirical Remote Sensing Algorithms to Retrieve SPM and CDOM in Québec Coastal Waters
Authors: Mabit Raphaël , Araújo Carlos A. S. , Singh Rakesh Kumar , Bélanger Simon
Published: April 2022

In most coastal waters, riverine inputs of suspended particulate matter (SPM) and colored dissolved organic matter (CDOM) are the primary optically active constituents. Moderate- and high-resolution satellite optical sensors, such as the Operational Land Imager (OLI) on Landsat-8 and the MultiSpectral Instrument (MSI) on Sentinel-2, offer a synoptic view at high spatial resolution (10–30 m) with weekly revisits allowing the study of coastal dynamics (e.g., river plumes and sediment re-suspension events). Accurate estimations of CDOM and SPM from space require regionally tuned bio-optical algorithms. Using an in situ dataset of CDOM, SPM, and optical properties (both apparent and inherent) from various field campaigns carried out in the coastal waters of the estuary and Gulf of St. Lawrence (EGSL) and eastern James Bay (JB) (N = 347), we developed regional algorithms for OLI and MSI sensors. We found that CDOM absorption at 440 nm [ag (440)] can be retrieved using the red-to-green band ratio for both EGSL and JB. In contrast, the SPM algorithm required regional adjustments due to significant differences in mass-specific inherent optical properties. Finally, the application of regional algorithms to satellite images from OLI and MSI indicated that the atmospheric correction (AC) algorithm C2RCC gives the most accurate remote-sensing reflectance (Rrs) absolute values. However, the ACOLITE algorithm gives the best results for CDOM estimation (almost null bias; median symmetric accuracy of 45% and R2 of 0.78) as it preserved the Rrs spectral shape, while tending to yield positively bias SPM (88%). We conclude that the choice of the algorithm depends on the parameter of interest.
Design and Evaluation of an Exergaming System for Children With Autism Spectrum Disorder: The Children’s and Families’ Perspective
Authors: Graham T. C. Nicholas , King Nia , Coo Helen , Zabojnikova Pavla , Gurd Brendon J. , Samdup Dawa
Published: April 2022

Children with autism spectrum disorder (ASD) have lower levels of physical activity than their typically developing peers. Barriers to participation include deficits in motor function and in social interaction, both of which reduce opportunities to engage in leisure activities that incorporate physical exertion. Because children with ASD also have higher than average levels of media use, exergames—video games that require bodily interaction to play—are a promising form of exercise. While studies have examined exergaming interventions for children with ASD, to date there has been little research on exergames that have been specifically designed for children with neurodevelopmental disorders, or qualitative analysis of players’ and families’ experience with exergaming programs. In this paper we present Liberi, an exergaming system involving kinaesthetic interaction within a virtual world, and designed explicitly for children with neurodevelopmental disorders. We report the results of a 6-week study where Liberi was played from the home by five children with ASD. The paper describes those aspects of the design that were successful and unsuccessful; how children and parents viewed the exergames; how the games were incorporated into the children’s lives; and how parents envisaged exergames could be best deployed for children with ASD.