bluuebunny/crossref_metadata_2025 huggingface dataset:
Optical hydrogen sensing with high-Q guided-mode resonance of Al2O3/WO3/Pd nanostructure
Authors: Kulikova Daria P. , Sgibnev Yevgeniy M. , Yankovskii Georgiy M. , Chubchev Eugeny D. , Lotkov Evgeniy S. , Ezenkova Daria A. , Dobronosova Alina A. , Baburin Aleksandr S. , Rodionov Ilya A. , Nechepurenko Igor A. , Baryshev Alexander V. , Dorofeenko Alexander V.
Published: January 2023

Nanostructure based on a dielectric grating (Al2O3), gasochromic oxide (WO3) and catalyst (Pd) is proposed as a hydrogen sensor working at the room temperature. In the fabricated structure, the Pd catalyst film was as thin as 1 nm that allowed a significant decrease in the optical absorption. A high-Q guided-mode resonance was observed in a transmission spectrum at normal incidence and was utilized for hydrogen detection. The spectra were measured at 0–0.12% of hydrogen in a synthetic air (≈ 80% $${\text{N}}_{2}$$

N
2

and 20% $${\text{O}}_{2}$$

O
2

). The detection limit below 100 ppm of hydrogen was demonstrated. Hydrogen was detected in the presence of oxygen, which provides the sensor recovery but suppresses the sensor response. Sensor response was treated by the principal component analysis (PCA), which effectively performs noise averaging. Influence of temperature and humidity was measured and processed by PCA, and elimination of the humidity and temperature effects was performed. Square root dependence of the sensor response on the hydrogen concentration (Sievert’s law) was observed. Sensor calibration curve was built, and the sensor resolution of 40 ppm was found. Long term stability of the sensor was investigated. Particularly, it was shown that the sensor retains its functionality after 6 months and dozens of acts of response to gas.
Blood leukocyte transcriptional modules and differentially expressed genes associated with disease severity and age in COVID-19 patients
Authors: Bando Silvia Y. , Bertonha Fernanda B. , Vieira Sandra E. , de Oliveira Danielle B. L. , Chalup Vanessa N. , Durigon Edison L. , Palmeira Patricia , Curi Ana Cristina P. , Faria Caroline S. , Antonangelo Leila , Lauterbach Gerhard da P. , Regalio Fabiane A. , Cesar Jr Roberto M. , Moreira-Filho Carlos A.
Published: January 2023

Since the molecular mechanisms determining COVID-19 severity are not yet well understood, there is a demand for biomarkers derived from comparative transcriptome analyses of mild and severe cases, combined with patients’ clinico-demographic and laboratory data. Here the transcriptomic response of human leukocytes to SARS-CoV-2 infection was investigated by focusing on the differences between mild and severe cases and between age subgroups (younger and older adults). Three transcriptional modules correlated with these traits were functionally characterized, as well as 23 differentially expressed genes (DEGs) associated to disease severity. One module, correlated with severe cases and older patients, had an overrepresentation of genes involved in innate immune response and in neutrophil activation, whereas two other modules, correlated with disease severity and younger patients, harbored genes involved in the innate immune response to viral infections, and in the regulation of this response. This transcriptomic mechanism could be related to the better outcome observed in younger COVID-19 patients. The DEGs, all hyper-expressed in the group of severe cases, were mostly involved in neutrophil activation and in the p53 pathway, therefore related to inflammation and lymphopenia. These biomarkers may be useful for getting a better stratification of risk factors in COVID-19.
Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination
Authors: Hu Jianjian , Jiang Wenxue , Zuo Jiaqi , Shi Dujuan , Chen Xiaoqi , Yang Xiao , Zhang Wenhui , Ma Lixin , Liu Zhu , Xing Qiong
Published: January 2023

Tumor suppressor p53 prevents tumorigenesis by promoting cell cycle arrest and apoptosis through transcriptional regulation. Dysfunction of p53 occurs frequently in human cancers. Thus, p53 becomes one of the most promising targets for anticancer treatment. A bacterial effector protein azurin triggers tumor suppression by stabilizing p53 and elevating its basal level. However, the structural and mechanistic basis of azurin-mediated tumor suppression remains elusive. Here we report the atomic details of azurin-mediated p53 stabilization by combining X-ray crystallography with nuclear magnetic resonance. Structural and mutagenic analysis reveals that the p28 region of azurin, which corresponds to a therapeutic peptide, significantly contributes to p53 binding. This binding stabilizes p53 by disrupting COP1-mediated p53 ubiquitination and degradation. Using the structure-based design, we obtain several affinity-enhancing mutants that enable amplifying the effect of azurin-induced apoptosis. Our findings highlight how the structure of the azurin-p53 complex can be leveraged to design azurin derivatives for cancer therapy.
Superconducting single-photon detectors in the mid-infrared for physical chemistry and spectroscopy
Authors: Lau Jascha A. , Verma Varun B. , Schwarzer Dirk , Wodtke Alec M.
Published: January 2023

Superconductivity in a nanowire is destroyed by absorption of an infrared photon allowing single-photon detection in the mid-infrared. Superconducting nanowire single-photon detectors have enormous potential for spectroscopic applications in molecular science.
A ratiometric nanoprobe for the in vivo bioimaging of hypochlorous acid to detect drug-damaged liver and kidneys
Authors: Shangguan Lina , Qian Xiaoli , Wu Zhuoyang , Han Tingting , Sun Wanlu , Liu Li , Liu Yi
Published: January 2023

In this manuscript, we report a mitochondria-targeted near-infrared ratiometric nanoprobe NRH800-PEG for detecting HClO in the mitochondria of living cells and tissues of drug-damaged liver and kidneys.
Deep learning-assisted analysis of single molecule dynamics from liquid-phase electron microscopy
Authors: Cheng Bin , Ye Enze , Sun He , Wang Huan
Published: January 2023

Deep learning methods, U-Net, UNet++, were applied to the analysis of single molecule movies obtained from liquid-phase electron microscopy.
Tracking endoplasmic reticulum viscosity during ferroptosis and autophagy using a molecular rotor probe
Authors: Silswal Akshay , Koner Apurba Lal
Published: January 2023

We have designed and synthesized a viscosity-sensitive, far-red emissive, ER-selective, and molecular rotor probe JER to monitor the ER fate during ferroptosis and ER-phagy processes.
An ab initio approach to anisotropic alloying into the Si(001) surface
Authors: Prodan D. V. , Paradezhenko G. V. , Yudin D. , Pervishko A. A.
Published: January 2023

We address the initial stage of co-deposited indium and silver atom growth on a silicon surface from a theoretical perspective.
Observation of slow magnetic relaxation phenomena in spatially isolated π-radical ions
Authors: Koyama Shohei , Sato Kazunobu , Yamashita Masahiro , Sakamoto Ryota , Iguchi Hiroaki
Published: January 2023

AC susceptibility measurements in the crystalline state and pulsed ESR measurements in the solution state provide insight into the relaxation of π-conjugated radical ions.
Coupled MoO3−x@CoP heterostructure as a pH-universal electrode for hydrogen generation at a high current density
Authors: Chen Pengzuo , Li Kaixun , Ye Yutong , Wu Doufeng , Tong Yun
Published: January 2023

A self-supporting electrode with a coupled hierarchical heterostructure was created by simple methods. It comprised MoO3−x and CoP on nickel foam, and represented a highly active pH-universal electrocatalyst for the HER at a high current density.
Cadmium-containing windmill-like heteropolyoxoniobate macrocycle with high yield for catalyzing Knoevenagel condensation
Authors: Liu Zheng-Yi , Ye Jian-Ping , Li Yi-Lun , Sun Yan-Qiong , Li Xin-Xiong , Sun Cai , Zheng Shou-Tian
Published: January 2023

A rare cadmium-containing windmill-like heteropolyoxoniobate macrocycle has been successfully synthesized with stable 1-D cyclic cluster aggregates.
Low strength and COD/N wastewater treatment via controlled nitrification by a membrane aerated biofilm, partial denitrification by activated sludge, and anaerobic ammonia oxidation by granular sludge
Authors: Rong Hong-Wei , Jiang Yu-Duo , Luo Zhao-Qing , Wei Chun-Hai , Jiang Xing , Zhang Li-Qiu , Ngo Huu Hao
Published: January 2023

Simultaneous carbon and nitrogen removal capacity of 0.36 gCOD L−1 d−1 and 0.23 gN L−1 d−1 is achieved for a hybrid MAB–PD–ANAMMOX process treating synthetic wastewater (COD 175 mg L−1, NH4+–N 100 mg L−1).
Eriodictyol: a review of its pharmacological activities and molecular mechanisms related to ischemic stroke
Authors: Guo Sa , Xing Nan , Xiang Gelin , Zhang Yi , Wang Shaohui
Published: January 2023

Schematic illustration of the core points related in this review.
‘Chemistry at the speed of sound’: automated 1536-well nanoscale synthesis of 16 scaffolds in parallel
Authors: Gao Li , Shaabani Shabnam , Reyes Romero Atilio , Xu Ruixue , Ahmadianmoghaddam Maryam , Dömling Alexander
Published: January 2023

Sustainable synthesis of highly diverse screening libraries of small molecules.
The E factor at 30: a passion for pollution prevention
Authors: Sheldon Roger Arthur
Published: January 2023

Publication of the E Factor drew attention to the problem of waste in chemicals manufacture. Thirty yeas later it is abundantly clear that waste is the underlying cause of global environmental problems, from climate change to plastic pollution.
Broadband absorption and light-energy transfer in a phenyl-core thiophene dendrimer with multiple π-conjugations
Authors: Yamagishi Mizuho , Horike Shohei , Koshiba Yasuko , Mori Atsunori , Ishida Kenji
Published: January 2023

Broadband absorption and unique light-energy transfer in a phenyl-core thiophene dendrimer is characterized spectroscopy and quantum calculations.
One-pot carboxyl enrichment fosters water-dispersibility of reduced graphene oxide: a combined experimental and theoretical assessment
Authors: Amato Francesco , Motta Alessandro , Giaccari Leonardo , Di Pasquale Roberto , Scaramuzzo Francesca Anna , Zanoni Robertino , Marrani Andrea Giacomo
Published: January 2023

A new carboxylation of graphene oxide is possible using succinic anhydride, exploiting an unexampled reactivity of epoxide groups. The carboxyl-enriched GO can then be chemically reduced obtaining an unprecedented water-dispersible RGO material.
The order of loading affects photocatalytic nitrogen fixation activity of the ternary composites of PdO/Au–TiO2
Authors: Wang Xuejing , Liu Sifan , Ma Ruixiao , Yang Wenwen , Chen Yanmei , Xu Juan , Zhang Yanhui
Published: January 2023

We applied PdO/Au–TiO2 to photocatalytic nitrogen fixation and found that Au, as electron transport channel, is conducive to N2 fixation.
Photocontrolled DNA nanotubes as stiffness tunable matrices for controlling cellular behavior
Authors: Sethi Soumya , Emura Tomoko , Hidaka Kumi , Sugiyama Hiroshi , Endo Masayuki
Published: January 2023

Cell behavior is determined by a variety of properties of the extracellular environment like ligand spacing, nanotopography, and matrix stiffness.
The enhancement in the performance of ultra-small core–shell Au@AuPt nanoparticles toward HER and ORR by surface engineering
Authors: Yue Xinru , Zhang Xiang , Zhang Mengmeng , Du Wei , Xia Haibing
Published: January 2023

The performance of ultra-small core–shell Au–Pt nanoparticles towards HER and ORR is further improved by surface engineering.
Edge-oriented phosphatizing engineering of 2D Ni-MOFs with a tailored d-band center for boosting catalytic activity
Authors: Wang Chongchong , Kong Lulu , Chen Bingbing , Zhou Lin , Wang Wei , Wei Shaohua
Published: January 2023

Edge-oriented phosphatization of Ni-MOF was realized for the first time and its excellent catalytic hydrogenation was proved.
Nonlocal and cascaded effects in nonlinear graphene nanoplasmonics
Authors: Rasmussen Theis P. , Rodríguez Echarri A. , García de Abajo F. Javier , Cox Joel D.
Published: January 2023

Plasmon-assisted harmonic generation in highly-doped graphene nanoribbons is strongly enhanced by the nonlocal optical response associated with large electromagnetic field gradients in closely-spaced ribbons that have optimal size and position.
Quantitative analysis of steric effects on the regioselectivity of the Larock heteroannulation reaction
Authors: Thangsan Poomsith , Rukkijakan Thanya , Thanaussavadate Bongkotrat , Yiamsawat Kanyapat , Sirijaraensre Jakkapan , Gable Kevin P. , Chuawong Pitak
Published: January 2023

A comprehensive predictive model for regioselectivity in the Larock heteroannulation reaction was constructed. The model provides support for a general blueprint for understanding the steric influence on the reaction selectivity.
Atom-economical synthesis of 1,2-bis(phosphine oxide)ethanes from calcium carbide with straightforward access to deuterium- and13C-labeled bidentate phosphorus ligands and metal complexes
Authors: Lotsman Kristina A. , Rodygin Konstantin S. , Skvortsova Irina , Kutskaya Anastasia M. , Minyaev Mikhail E. , Ananikov Valentine P.
Published: January 2023

Straightforward access to bidentate phosphorus ligands and bis(phosphineoxide)ethanes is described based on atom-economic addition reaction. A practical approach was developed to incorporate2H and13C labels using easily available reagents.
High utilization efficiencies of alkylbenzokynones hybridized inside the pores of activated carbon for electrochemical capacitor electrodes
Authors: Itoi Hiroyuki , Matsuura Miku , Tanabe Yuichiro , Kondo Shoya , Usami Takanori , Ohzawa Yoshimi
Published: January 2023

Benzoquinone derivatives are hybridized inside the pores of activated carbon via gas-phase adsorption. Alkylbenzoquinones have strong interaction with the carbon pore surface while the intermolecular interaction is dominant for halobenzoquinones.
Rapid adsorption enthalpy surface sampling (RAESS) to characterize nanoporous materials
Authors: Ren Emmanuel , Coudert François-Xavier
Published: January 2023

To speed up the calculation of adsorption enthalpy, a new algorithm changes the 3D problem into 2D sampling. It reduces the computational cost of large-scale screening of nanoporous materials for applications like fluid separation and storage.
A cost-effective aptasensor capable of early diagnosis and monitoring of Alzheimer's disease with the rapid analysis of beta-amyloid peptide 1–40
Authors: Khang Ashley , Idegwu Nnebuefe , Lee Ji Hoon
Published: January 2023

A cost-effective biosensor with guanine chemiluminescence detection capable of sensing trace levels of beta-amyloid peptide 1–40 was developed for the early diagnosis and accurate monitoring of Alzheimer's disease (AD).
A high-energy hybrid lithium-ion capacitor enabled by a mixed capacitive-battery storage LiFePO4 – AC cathode and a SnP2O7 – rGO anode
Authors: Granados-Moreno Miguel , Moreno-Fernández Gelines , Mysyk Roman , Carriazo Daniel
Published: January 2023

In this work we present the development and optimization of a graphene-embedded Sn-based material and an activated carbon/lithium iron phosphate composite for a high-performing hybrid lithium-ion capacitor (LIC).
A polymer chain with dipolar active forces in connection to spatial organization of chromatin
Authors: Chaki Subhasish , Theeyancheri Ligesh , Chakrabarti Rajarshi
Published: January 2023

Enhanced (or reduced) subdiffusive dynamics and spatially coherent motion of model chromatin driven by extensile (or contractile) activity.
Diffusiophoresis of a spherical particle in porous media
Authors: Sambamoorthy Siddharth , Chu Henry C. W.
Published: January 2023

We develop a mathematical model that can predict the diffusiophoretic motion of a charged colloidal particle driven by a binary monovalent electrolyte concentration gradient in porous media.
Demonstrating the source of inherent instability in NiFe LDH-based OER electrocatalysts
Authors: Tyndall Daire , Craig Michael John , Gannon Lee , McGuinness Cormac , McEvoy Niall , Roy Ahin , García-Melchor Max , Browne Michelle P. , Nicolosi Valeria
Published: January 2023

During their lifetime, the electrocatalytically active NiFe LDH platelets show impressive, but unstable water-splitting capabilities due largely to compositional degradation.
Tailoring stability, catalytic activity and selectivity of covalent metal–organic frameworks via steric modification of metal nodes
Authors: Duan Haiyan , Chen Xu , Yang Yi-Nan , Zhao Jianping , Lin Xiao-Chun , Tang Wen-Jing , Gao Qiang , Ning Guo-Hong , Li Dan
Published: January 2023

A novel and efficient strategy was developed to enhance the stability, control the catalytic activity, and improve the selectivity of Cu(i) cyclic trinuclear unit (Cu-CTU)-based metal–organic frameworks by steric modification of copper nodes.
Polyiodide shuttle inhibition in ethylene glycol-added aqueous electrolytes for high energy and long-term cyclability of zinc–iodine batteries
Authors: Zhang Jing , Dou Qingyun , Yang Chao , Zang Limin , Yan Xingbin
Published: January 2023

High-density ordered porous graphene is used as the iodine host material and ethylene glycol is added to electrolyte to inhibit the polyiodide shuttle, so high volumetric energy and long cycling life are achieved for the Zn–I2 batteries.
Gold nanocluster decorated fibrous substrate for photo-modulated cellular growth
Authors: Li Bowen , Kang Yuetong , Wang Xiaoyu , Zhang Pengbo , Li Lidong
Published: January 2023

By programmable annealing, photothermal gold nanoclusters were integrated into filamentous aggregates of gellan gum to obtain a photofunctional fibrous substrate that enhanced cell adhesion and permitted light-triggered cell growth promotion.
Correction: Modulation of the kinetics of outer-sphere electron transfer at graphene by a metal substrate
Authors: Pavlov Sergey V. , Kozhevnikova Ekaterina O. , Kislenko Vitaliy A. , Kislenko Sergey A.
Published: January 2023

Correction for ‘Modulation of the kinetics of outer-sphere electron transfer at graphene by a metal substrate’ by Sergey V. Pavlov et al., Phys. Chem. Chem. Phys., 2022, 24, 25203–25213, https://doi.org/10.1039/D2CP03771H.
Correction: Manipulation of oxygen evolution reaction kinetics of a free-standing CoSe2–NiSe2 heterostructured electrode by interfacial engineering
Authors: Rauf Muhammad , Yang Ling , Wang Jingwen , Mi Hongwei , Zhang Qianling , Zhang Peixin , Ren Xiangzhong , Li Yongliang
Published: January 2023

Correction for ‘Manipulation of oxygen evolution reaction kinetics of a free-standing CoSe2–NiSe2 heterostructured electrode by interfacial engineering’ by Muhammad Rauf et al., Sustainable Energy Fuels, 2022, 6, 5392–5399, https://doi.org/10.1039/D2SE01259F.
Correction: Tuning and understanding the electronic effect of Co–Mo–O sites in bifunctional electrocatalysts for ultralong-lasting rechargeable zinc–air batteries
Authors: Guan Yi , Li Nan , He Jiao , Li Yongliang , Zhang Lei , Zhang Qianling , Ren Xiangzhong , He Chuanxin , Zheng LiRong , Sun Xueliang
Published: January 2023

Correction for ‘Tuning and understanding the electronic effect of Co–Mo–O sites in bifunctional electrocatalysts for ultralong-lasting rechargeable zinc–air batteries’ by Yi Guan et al., J. Mater. Chem. A, 2021, 9, 21716–21722, https://doi.org/10.1039/D1TA04408G.
Skin-specific mechanisms of body fluid regulation in hypertension
Authors: Chen Jun Yu , Chew Khai Syuen , Mary Sheon , Boder Philipp , Bagordo Domenico , Rossi Gian Paolo , Touyz Rhian M. , Delles Christian , Rossitto Giacomo
Published: January 2023

Increasing evidence suggests excess skin Na+ accumulation in hypertension; however, the role of skin-specific mechanisms of local Na+/water regulation remains unclear. We investigated the association between measures of sweat and trans-epidermal water loss (TEWL) with Na+ content in the skin ([Na+]skin) and clinical characteristics in consecutive hypertensive patients. We obtained an iontophoretic pilocarpine-induced sweat sample, a skin punch biopsy for chemical analysis, and measures of TEWL from the upper limbs. Serum vascular endothelial growth factor-c (VEGF-c) and a reflectance measure of haemoglobin skin content served as surrogates of skin microvasculature. In our cohort (n = 90; age 21–86 years; females = 49%), sweat composition was independent of sex and BMI. Sweat Na+ concentration ([Na+]sweat) inversely correlated with [K+]sweat and was higher in patients on ACEIs/ARBs (P < 0.05). A positive association was found between [Na+]sweat and [Na+]skin, independent of sex, BMI, estimated Na+ intake and use of ACEi/ARBs (Padjusted = 0.025); both closely correlated with age (P < 0.01). Office DBP, but not SBP, inversely correlated with [Na+]sweat independent of other confounders (Padjusted = 0.03). Total sweat volume and Na+ loss were lower in patients with uncontrolled office BP (Padjusted < 0.005 for both); sweat volume also positively correlated with serum VEGF-c and TEWL. Lower TEWL was paralleled by lower skin haemoglobin content, which increased less after vasodilatory pilocarpine stimulation when BMI was higher (P = 0.010). In conclusion, measures of Na+ and water handling/regulation in the skin were associated with relevant clinical characteristics, systemic Na+ status and blood pressure values, suggesting a potential role of the skin in body-fluid homeostasis and therapeutic targeting of hypertension.
Predicting recurrence in osteosarcoma via a quantitative histological image classifier derived from tumour nuclear morphological features
Authors: Wang Zhan , Lu Haoda , Wu Yan , Ren Shihong , Diaty Diarra mohamed , Fu Yanbiao , Zou Yi , Zhang Lingling , Wang Zenan , Wang Fangqian , Li Shu , Huo Xinmi , Yu Weimiao , Xu Jun , Ye Zhaoming
Published: January 2023

Recurrence is the key factor affecting the prognosis of osteosarcoma. Currently, there is a lack of clinically useful tools to predict osteosarcoma recurrence. The application of pathological images for artificial intelligence‐assisted accurate prediction of tumour outcomes is increasing. Thus, the present study constructed a quantitative histological image classifier with tumour nuclear features to predict osteosarcoma outcomes using haematoxylin and eosin (H&E)‐stained whole‐slide images (WSIs) from 150 osteosarcoma patients. We first segmented eight distinct tissues in osteosarcoma H&E‐stained WSIs, with an average accuracy of 90.63% on the testing set. The tumour areas were automatically and accurately acquired, facilitating the tumour cell nuclear feature extraction process. Based on six selected tumour nuclear features, we developed an osteosarcoma histological image classifier (OSHIC) to predict the recurrence and survival of osteosarcoma following standard treatment. The quantitative OSHIC derived from tumour nuclear features independently predicted the recurrence and survival of osteosarcoma patients, thereby contributing to precision oncology. Moreover, we developed a fully automated workflow to extract quantitative image features, evaluate the diagnostic values of feature sets and build classifiers to predict osteosarcoma outcomes. Thus, the present study provides a novel tool for predicting osteosarcoma outcomes, which has a broad application prospect in clinical practice.
A threshold‐based sorting algorithm for dense wireless sensor systems and communication networks
Authors: Shirvani Moghaddam Shahriar , Shirvani Moghaddam Kiaksar
Published: January 2023

Nowadays, time‐varying and high‐density data of wireless sensor systems and communication networks compel us to propose and realise low‐complexity and time‐efficient algorithms for searching, clustering, and sorting. A novel threshold‐based sorting algorithm applicable to dense and ultra‐dense networks is proposed in this study. Instead of sorting whole data in a large data set and selecting a certain number of them, the proposed algorithm sorts a specific number of elements that are larger or smaller than a threshold level or located between two threshold values. First, based on the mean value and standard deviation of the data, a theoretical analysis to find the exact and approximate thresholds, respectively for known (Gaussian, uniform, Rayleigh, and negative exponential) and unknown probability distributions is presented. Then, an algorithm to sort a predefined number of data is realised. Finally, the effectiveness of the proposed algorithm is shown in the view of the time complexity order, the running time, and the similarity measure. To do this, theoretical and numerical analyses are used to show the superiority of the proposed algorithm in known and unknown distributions to the well‐known conventional and gradual conventional versions of Merge, Quick, and K‐S mean‐based sorting algorithms.
GaiaData Release 3
Authors: Holl B. , Sozzetti A. , Sahlmann J. , Giacobbe P. , Ségransan D. , Unger N. , Delisle J.-B. , Barbato D. , Lattanzi M. G. , Morbidelli R. , Sosnowska D.
Published: January 2023

Context.The astrometric discovery of sub-stellar mass companions orbiting stars is exceedingly hard due to the required sub-milliarcsecond precision, limiting the application of this technique to only a few instruments on a target-per-target basis and to the global astrometry space missions HIPPARCOSandGaia. The thirdGaiadata release (GaiaDR3) includes the firstGaiaastrometric orbital solutions whose sensitivity in terms of estimated companion mass extends down to the planetary-mass regime.

Aims.We present the contribution of the exoplanet pipeline to theGaiaDR3 sample of astrometric orbital solutions by describing the methods used for fitting the orbits, the identification of significant solutions, and their validation. We then present an overview of the statistical properties of the solution parameters.

Methods.Using both a Markov chain Monte Carlo and a genetic algorithm, we fitted the 34 months ofGaiaDR3 astrometric time series with a single Keplerian astrometric-orbit model that had 12 free parameters and an additional jitter term, and retained the solutions with the lowestχ2. Verification and validation steps were taken using significance tests, internal consistency checks using theGaiaradial velocity measurements (when available), as well as literature radial velocity and astrometric data, leading to a subset of candidates that were labelled “validated”.

Results.We determined astrometric-orbit solutions for 1162 sources, and 198 solutions were assigned the “Validated” label. Precise companion-mass estimates require external information and are presented elsewhere. To broadly categorise the different mass regimes in this paper, we use the pseudo-companion massM̃cassuming a solar-mass host and define three solution groups: 17 (9 validated) solutions with companions in the planetary-mass regime (M̃c< 20MJ), 52 (29 validated) in the brown dwarf regime (20MJ≤M̃c≤ 120  MJ), and 1093 (160 validated) in the low-mass stellar companion regime (M̃c> 120MJ). From internal and external verification and validation, we estimate the level of spurious and incorrect solutions in our sample to be ∼5% and ∼10% in the ‘OrbitalAlternative’ and ‘OrbitalTargetedSearch’ candidate sample, respectively.

Conclusions.We demonstrate thatGaiais able to confirm and sometimes refine the orbits of known orbital companions and to identify new candidates, providing us with a positive outlook for the expected harvest from the full mission data in future data releases.
Filaments in the OMC-3 cloud and uncertainties in estimates of filament profiles
Authors: Juvela M. , Mannfors E.
Published: January 2023

Context.Filamentary structures are an important part of star-forming interstellar clouds. The properties of filaments hold clues to their formation mechanisms and their role in the star-formation process.

Aims.We compare the properties of filaments in the Orion Molecular Cloud 3 (OMC-3), as seen in mid-infrared (MIR) absorption and far-infrared (FIR) dust emission. We also wish to characterise some potential sources of systematic errors in filament studies.

Methods.We calculated optical depth maps of the OMC-3 filaments based on the MIR absorption seen inSpitzerdata and FIR dust emission observed withBerscheland the ArTéMiS instrument. We then compared the filament properties extracted from the data. Potential sources of error were investigated more generally with the help of radiative transfer models.

Results.The widths of the selected OMC-3 filament segments are in the range 0.03–0.1 pc, with similar average values seen in both MIR and FIR analyses. Compared to the widths, the individual parameters of the fitted Plummer functions are much more uncertain. The asymptotic power-law index has typically valuesp ~3 but with a large scatter. Modelling shows that the FIR observations can systematically overestimate the filament widths. The effect is potentially tens of per cent at column densities aboveN(H2) ~ 1022cm–2but is reduced in more intense radiation fields, such as the Orion region. Spatial variations in dust properties could cause errors of similar magnitude. In the MIR analysis, dust scattering should generally not be a significant factor, unless there are high-mass stars nearby or the dust MIR scattering efficiency is higher than in the tested dust models. Thermal MIR dust emission can be a more significant source of error, especially close to embedded sources.

Conclusions.The analysis of interstellar filaments can be affected by several sources of systematic error, but mainly at high column densities and, in the case of FIR observations, in weak radiation fields. The widths of the OMC-3 filaments were consistent between the MIR and FIR analyses and did not reveal any systematic dependence on the angular resolution of the observations.
Modeling continuum polarization levels of tidal disruption events based on the collision-induced outflow model
Authors: Charalampopoulos P. , Bulla M. , Bonnerot C. , Leloudas G.
Published: January 2023

Tidal disruption events (TDEs) have been observed in the optical and ultraviolet (UV) for more than a decade, but the underlying emission mechanism still remains a puzzle. It has been suggested that viewing angle effects could potentially explain their large photometric and spectroscopic diversity. Polarization is indeed sensitive to the viewing angle and the first polarimetry studies of TDEs are now available, calling for a theoretical interpretation. In this study, we model the continuum polarization levels of TDEs using the three-dimensional (3D) Monte Carlo radiative transfer code POSSIS and the collision-induced outflow (CIO) TDE emission scenario, where unbound shocked gas originating from a debris stream intersection point offset from the black hole (BH), reprocesses the hard emission from the accretion flow into UV and optical bands. We explore two different cases of peak mass fallback rates Ṁp (∼ 3 M⊙ yr−1 and ∼ 0.3 M⊙ yr−1) while varying the following geometrical parameters: the distance Rint from the BH to the intersection point where the stellar debris stream self intersects; the radius of the photosphere around the BH Rph, on the surface of which the optical and UV photons are generated; and the opening angle Δθ that defines the fraction of the surface of the photosphere on which the photons are generated (anisotropic emission). For the high mass fallback rate case, we find for every viewing angle polarization levels below one (P < 1%) and P < 0.5% for ten out of 12 simulations. The absolute value of polarization reaches its maximum (Pmax) for equatorial viewing angles. For the low mass fallback rate case, the model can produce a wide range of polarization levels for different viewing angles and configurations. The maximum value predicted is P ≈ 8.8% and Pmax is reached for intermediate viewing angles. We find that the polarization strongly depends on (i) the optical depths at the central regions (between the emitting photosphere and the intersection point) set by the different Ṁp values and (ii) the viewing angle. With time, there is a drop in densities and optical depths leading to a general increase in polarization values and Pmax, although the opposite trend can be observed for specific viewing angles. Increasing the distance Rint between the intersection point and the BH seems to generally favor higher polarization levels. Finally, by comparing our model predictions to polarization observations of a few TDEs, we attempt to constrain their observed viewing angles and we show that multi-epoch polarimetric observations can become a key factor in constraining the viewing angle of TDEs.
The SOUL view of IRAS 20126+4104
Authors: Massi F. , Caratti o Garatti A. , Cesaroni R. , Sridharan T. K. , Ghose E. , Pinna E. , Beltrán M. T. , Leurini S. , Moscadelli L. , Sanna A. , Agapito G. , Briguglio R. , Christou J. , Esposito S. , Mazzoni T. , Miller D. , Plantet C. , Power J. , Puglisi A. , Rossi F. , Rothberg B. , Taylor G. , Veillet C.
Published: January 2023

Context. We exploit the increased sensitivity of the recently installed adaptive optics SOUL at the LBT to obtain new high-spatial-resolution near-infrared images of the massive young stellar object IRAS20126+4104 and its outflow.

Aims. We aim to derive the jet proper motions and kinematics, as well as to study its photometric variability by combining the novel performances of SOUL together with previous near-infrared images.

Methods. We used both broad-band (Ks, K′) and narrow-band (Brγ, H2) observations from a number of near-infrared cameras (UKIRT/UFTI, SUBARU/CIAO, TNG/NICS, LBT/PISCES, and LBT/LUCI1) to derive maps of the continuum and the H2 emission in the 2.12 µm line. Three sets of images, obtained with adaptive optics (AO) systems (CIAO, in 2003; FLAO, in 2012; SOUL, in 2020), allowed us to derive the proper motions of a large number of H2 knots along the jet. Photometry from all images was used to study the jet variability.

Results. We derived knot proper motions in the range of 1.7–20.3 mas yr−1 (i.e. 13–158 km s−1 at 1.64 kpc), implying an average outflow tangential velocity of ~80 km s−1. The derived knot dynamical age spans a ~200–4000 yr interval. A ring-like H2 feature near the protostar location exhibits peculiar kinematics and may represent the outcome of a wide-angle wind impinging on the outflow cavity. Both H2 geometry and velocities agree with those inferred from proper motions of the H2O masers, located at a smaller distance from the protostar. Although the total H2 line emission from the knots does not exhibit time variations at a ⪞0.3 mag level, we have found a clear continuum flux variation (radiation scattered by the dust in the cavity opened by the jet) which is anti-correlated between the blue-shifted and red-shifted lobes and may be periodic (with a period of ~12–18 yr). We suggest that the continuum variability might be related to inner-disc oscillations which have also caused the jet precession.

Conclusions. Our analysis shows that multi-epoch high-spatial-resolution imaging in the near-infrared is a powerful tool to unveil the physical properties of highly embedded massive protostars.
Leaky dust traps: How fragmentation impacts dust filtering by planets
Authors: Stammler Sebastian Markus , Lichtenberg Tim , Drążkowska Joanna , Birnstiel Tilman
Published: January 2023

The nucleosynthetic isotope dichotomy between carbonaceous (CC) and non-carbonaceous (NC) meteorites has been interpreted as evidence for spatial separation and the coexistence of two distinct planet-forming reservoirs for several million years in the solar protoplanetary disk. The rapid formation of Jupiter’s core within one million years after the formation of calcium-aluminium-rich inclusions (CAIs) has been suggested as a potential mechanism for spatial and temporal separation. In this scenario, Jupiter’s core would open a gap in the disk and trap inward-drifting dust grains in the pressure bump at the outer edge of the gap, separating the inner and outer disk materials from each other. We performed simulations of dust particles in a protoplanetary disk with a gap opened by an early-formed Jupiter core, including dust growth and fragmentation as well as dust transport, using the dust evolution software DustPy. Our numerical experiments indicate that particles trapped in the outer edge of the gap rapidly fragment and are transported through the gap, contaminating the inner disk with outer disk material on a timescale that is inconsistent with the meteoritic record. This suggests that other processes must have initiated or at least contributed to the isotopic separation between the inner and outer Solar System.
Importance de Mycoplasma bovis dans les affections respiratoires en fonction des systèmes de production
Authors: Belbis Guillaume
Published: January 2023

Mycoplasma bovis est une bactérie fréquemment impliquée dans les troubles respiratoires des jeunes bovins. Si elle peut à elle seule conduire à des lésions pulmonaires, elle est souvent considérée comme un agent potentialisateur, favorisant le développement d’autres agents secondaires. Son impact diffère selon les systèmes de production : des études de séroprévalence montrent une importance modérée mais variable en système naisseur, alors que son impact est plus fort dans les ateliers d’engraissement de veaux de boucherie.
La thrombose de la veine cave caudale : une affection sporadique difficile à diagnostiquer chez les bovins
Authors: Ravary-Plumioën Bérangère , Pierrot Émilie , Plassard Vincent
Published: January 2023

Chez les bovins, la thrombose de la veine cave caudale (TVCC) voire de la veine cave crâniale est une affection sporadique, difficile à diagnostiquer du vivant de l’animal du fait d’une symptomatologie souvent fruste. Certains signes cliniques et résultats d’examens complémentaires (analyses sanguines, échographie) permettent cependant d’orienter le diagnostic face à cette affection sans possibilité de guérison. Au travers de 17 cas diagnostiqués à l’École Nationale Vétérinaire d’Alfort (EnvA), l’article relate les présentations cliniques et paracliniques de cette affection. La majorité des animaux atteints présentait des signes d’atteinte respiratoire chronique associés à une baisse de l’état général, et très rarement de l’épistaxis ou de l’hémoptysie secondaire aux hémorragies pulmonaires. L’échographie transcutanée de la région du foie effectuée chez 9 des 17 bovins a permis de mettre en évidence, du vivant des animaux, une dilatation de la veine cave caudale dans 100 % des cas (9 bovins), une congestion veineuse du foie dans 56 % des cas, un thrombus au sein de la lumière de la veine dans 44 % (4 bovins), une hépatomégalie dans 33 % et des abcès hépatiques dans 22 %. L’échographie reste toutefois l’examen de choix pour le diagnostic de la TVCC du vivant de l’animal. À défaut d’échographie, des examens sanguins permettent parfois de suspecter une TVCC ou d’exclure d’autres affections appartenant au diagnostic différentiel. Ainsi, s’il n’est pas aisé de poser un diagnostic de certitude de TVCC du vivant de l’animal, le diagnostic de l’affection est généralement post-mortem avec visualisation d’un volumineux thrombus septique au sein de la veine cave associée souvent à des lésions de pneumonie métastatique ou d’hémorragie pulmonaire. L’affection primaire à l’origine de la TVCC n’est pas toujours facile à identifier ; il peut s’agir d’abcès hépatiques (retrouvés ici dans 53 % des cas), de mammite, de réticulo-péritonite (RPT) ou encore d’infection de l’appareil locomoteur.
No dislocation and low complication rate for a modern dual mobility cup with pre-impacted femoral head in primary hip replacement: A consecutive series of 175 hips at minimum 5-year follow-up
Authors: Foissey Constant , Batailler Cécile , Rajput Vishal , Premkumar Aditya B.J. , Servien Elvire , Lustig Sébastien
Published: January 2023

Introduction:Despite its excellent results in preventing dislocation, the dual mobility cup (DMC) is still struggling to be adopted by some teams due to premature wear and loosening reported on first-generation implants. Therefore, this study aimed to assess the mid-term survivorship of a modern DMC with a pre-impacted head and the radio-clinical results at a minimum follow-up of 5 years.Methods: This was a retrospective single-centre study performed on patients who had a primary total hip replacement for osteoarthritis in 2016. The cup was a third-generation DMC with a pre-impacted femoral head. Clinical (harris hip score (HHS)) and radiological (cup abduction, anteversion, overhang, and radiolucent lines) results were recorded, as well as complications, particularly dislocations and survivorship. A minimum of five years of follow-ups was required.Results: One hundred and seventy-five hips (167 patients) met the inclusion criteria. Five hips (2.9%, 5/175) were lost to follow-up and excluded from the postoperative analysis. The mean follow-up period was 70 ± 2.9 months [63.6–76.5]. Three cups needed revision surgery (1.8%, 3/170): one for septic loosening, and two for chronic infection. At 77 months, the global survival probability was 98.2% ± 1, and the survival probability excluding septic aetiology was 100%. There was a significant improvement in the HHS from pre-operatively (48.3 ± 6.0 [14.0–70.0]) to post-operatively (96 ± 4.5 [50–100]) (p < 0.0001). There were no postoperative dislocations recorded, nor any iliopsoas-impingement or symptomatic cam-effect.Discussion: This study showed excellent survival and good radiological and clinical results of this dual mobility cup at a mid-term follow-up. None of the patients had dislocation or any specific complication feared with dual mobility cups.
Measurement of spinopelvic sagittal alignment in the relaxed seated position rather than in the straight seated position is suitable for assessing spinopelvic mobility in patients before total hip arthroplasty
Authors: Ohyama Yohei , Iwakiri Kentaro , Ohta Yoichi , Minoda Yukihide , Kobayashi Akio , Nakamura Hiroaki
Published: January 2023

Purpose: The relationship between spinopelvic mobility and dislocation in total hip arthroplasty (THA) has recently attracted attention. This study aimed to investigate the differences in sacral slope (SS) between two types of upright seated positions and to determine which seated position was appropriate for assessing spinopelvic mobility (change in SS from standing to sitting) before THA. Materials and methods: This prospective cohort study included 75 hips from 75 patients who had undergone primary THA. Each patient underwent preoperative lateral spinopelvic radiography in standing (st) and two seated positions: relaxed (rs) and straight (ss). The change in SS between each position (Δ) was measured. Results: Differences in all spinopelvic sagittal alignment parameters between the two seated positions were statistically significant (p < 0.001). The range, median, and mean values of ΔSSss-rs were −2.0° to 26.5°, 6.8°, and 8.3°, respectively. ΔSSss-rs was significantly correlated with SS, LLA, and PFA in the relaxed seated position (r = −0.52, −0.39, and 0.37; p < 0.001, p < 0.001, and p = 0.001, respectively), but was not correlated to these parameters in the straight seated position. Of the 52 patients with normal spinopelvic mobility in the relaxed seated position (ΔSSst-rs > 10°), 24 (46%) patients were misrepresented as having a stiff spine in the straight seated position (ΔSSst-ss < 10°). Conclusion: The change in SS from the straight to the relaxed seated position widely varied in patients before THA. The spinopelvic radiograph in the relaxed seated position is appropriate when evaluating spinopelvic mobility for preoperative planning.
Diagnostic Accuracy of a Bespoke Multiorgan Ultrasound Approach in
Suspected Pulmonary Embolism
Authors: Falster Casper , Egholm Gro , Wiig Rune , Poulsen Mikael Kjær , Møller Jacob Eifer , Posth Stefan , Brabrand Mikkel , Laursen Christian Borbjerg
Published: January 2023

Purpose The aims of this study were to prospectively assess the diagnostic
accuracy of a bespoke multiorgan point-of-care ultrasound approach for suspected
pulmonary embolism and evaluate if this model allows reduced referral to further
radiation diagnostics while maintaining safety standards.

Materials and Methods Patients with suspected pulmonary embolism referred
for CT pulmonary angiography or ventilation/perfusion scintigraphy were
included as a convenience sample. All patients were subject to blinded
ultrasound investigation with cardiac, lung, and deep venous ultrasound. The
sensitivity and specificity of applied ultrasound signs and the hypothetical
reduction in the need for further diagnostic workup were calculated.

Results 75 patients were prospectively enrolled. The Wells score was below
2 in 48 patients, between 2 and 6 in 24 patients, and above 6 in 3 patients. The
prevalence of pulmonary embolism was 28%. The most notable ultrasound
signs were presence of a deep venous thrombus, at least two hypoechoic
pleural-based lesions, the D-sign, the 60/60-sign, and a visible right
ventricular thrombus which all had a specificity of 100%. Additionally,
a multiorgan ultrasound investigation with no findings compatible with pulmonary
embolism yielded a sensitivity of 95.2% (95%CI:
76.2–99.9). CT or scintigraphy could be safely avoided in 70% of
cases (95%CI: 63.0–83.1%).

Conclusion The findings of our study suggest that implementation of a
multiorgan ultrasound assessment in patients with suspected pulmonary embolism
may safely reduce the need for CT or scintigraphy by confirming or dismissing
the suspicion.
Universal pre-mixing dry-film stickers capable of retrofitting existing microfluidics
Authors: Delgado P. , Oshinowo O. , Fay M. E. , Luna C. A. , Dissanayaka A. , Dorbala P. , Ravindran A. , Shen L. , Myers D. R.
Published: January 2023

Integrating microfluidic mixers into lab-on-a-chip devices remains challenging yet important for numerous applications including dilutions, extractions, addition of reagents or drugs, and particle synthesis. High-efficiency mixers utilize large or intricate geometries that are difficult to manufacture and co-implement with lab-on-a-chip processes, leading to cumbersome two-chip solutions. We present a universal dry-film microfluidic mixing sticker that can retrofit pre-existing microfluidics and maintain high mixing performance over a range of Reynolds numbers and input mixing ratios. To attach our pre-mixing sticker module, remove the backing material and press the sticker onto an existing microfluidic/substrate. Our innovation centers around the multilayer use of laser-cut commercially available silicone-adhesive-coated polymer sheets as microfluidic layers to create geometrically complex, easy to assemble designs that can be adhered to a variety of surfaces, namely, existing microfluidic devices. Our approach enabled us to assemble the traditional yet difficult to manufacture “F-mixer” in minutes and conceptually extend this design to create a novel space-saving spiral F-mixer. Computational fluid dynamic simulations and experimental results confirmed that both designs maintained high performance for 0.1 < Re < 10 and disparate input mixing ratios of 1:10. We tested the integration of our system by using the pre-mixer to fluorescently tag proteins encapsulated in an existing microfluidic. When integrated with another microfluidic, our pre-mixing sticker successfully combined primary and secondary antibodies to fluorescently tag micropatterned proteins with high spatial uniformity, unlike a traditional pre-mixing “T-mixer” sticker. Given the ease of this technology, we anticipate numerous applications for point-of-care devices, microphysiological-systems-on-a-chip, and microfluidic-based biomedical research.