bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between Nutritional Status, Diet, and Calorie Adequacy on Work Fatigue of Female Pottery Crafters in Karanganyar Village, Borobudur, Magelang
Authors: Aprilia Shela , Paskarini Indriati , Martiana Tri , Widarjanto Widarjanto , Budi Santi Wirastri Hayuhaning
Published: November 2023

Background: Work Fatigue is a common condition often experienced by workers characterized by decreased work performance. Work fatigue can be caused by poor nutritional status, diet and calorie intake received by workers.
Objectives: This study purpose is to analyze the relationship between nutritional status, diet, calorie intake and work fatigue experienced by female pottery craftsmen in Karanganya Village, Central Java.
Methods: This research is a quantitative analytic research with cross-sectional study design. The study population was 70 female pottery artisans in Karanganyar Village, Borobudur District, Magelang Regency, Central Java. The number of samples taken was 43 people determined using simple random sampling. The variables studied were nutritional status, diet, calorie adequacy and physical labor fatigue. The instruments used were digital weight scales and staturemeter, Food Frequency Questionnaire, 24-hour food recall form and reaction timer. Data analysis techniques using SPSS with Chi-square test and logistic regression.
Results: 48,84% of pottery crafters have abnormal nutritional. 65.12% of pottery crafters have a good diet although 69.77% of the calorie adequacy of pottery crafters is not met. 34.88% of pottery craftsmen experienced physical fatigue in the moderate category and 4.65% experienced physical fatigue in the severe category. Based on the results of bivariate analysis, there is a relationship between diet (p=0.010), calorie adequacy (p=0.044) with physical work fatigue. There is no relationship between nutritional status (p=0.098) with physical fatigue.
Conclusions: Work fatigue experienced by female pottery crafters in Karanganyar Village is caused by diet and calorie adequacy deficits.
Pengaruh Edukasi Gizi Melalui Bampi App Terhadap Pengetahuan, Sikap, dan Keterampilan Ibu Bayi Dalam Pemberian MP-ASI di Desa Tumbang Samba Kecamatan Katingan Tengah
Authors: Sugiyanto Sugiyanto , Tsabitha Cindra Ainie , Normila Normila
Published: November 2023

Latar belakang: Saat bayi berusia 6 bulan, ASI tidak akan mampu memenuhi kebutuhan nutrisinya selama fase pertumbuhan sehingga makanan pendamping ASI perlu diperkenalkan. Upaya yang perlu dilakukan antara lain dengan melakukan kegiatan pendidikan kesehatan yang mempromosikan perilaku hidup sehat, salah satunya adalah edukasi gizi dengan menggunakan Bampi App. Penelitian ini menganalisis pengaruh edukasi gizi menggunakan Bampi App terhadap pengetahuan, sikap, dan keterampilan terkait penyiapan MP-ASI di Desa Tumbang Samba, Kecamatan Katingan Tengah.
Metode: Desain penelitian yang digunakan dalam penelitian ini adalah quasi-experiment dengan rancangan one-group pretest-posttest design. Sampel dalam penelitian ini terdiri dari 33 ibu yang memiliki bayi berusia 6-10 bulan, yang dipilih dengan metode purposive sampling. Data dianalisis dengan menggunakan uji McNemar.
Hasil: Hasil penelitian menunjukkan adanya peningkatan yang signifikan pada pengetahuan, sikap, dan keterampilan dalam memberikan MP-ASI pada bayi setelah intervensi (p-value = 0,000).
Kesimpulan: Penelitian ini menyimpulkan bahwa Bampi App dapat menjadi media alternatif bagi instansi dan tenaga kesehatan dalam memberikan edukasi untuk meningkatkan pengetahuan, sikap, dan keterampilan ibu dalam pemberian MP-ASI.
Literature Review: The Relationship between Eating Habits and Dyspepsia in Adolescents
Authors: Hidayat Rahmat , Susanto Agung , Lestari Anik
Published: November 2023

Background: All over the world the prevalence of dyspepsia is quite high. Various literature sources in western countries show that the prevalence of dyspepsia Various literature sources in western countries show that the prevalence of dyspepsia is in the range of 7-41% in 2009, but unfortunately only about 10-20% of patients seek treatment or medical help. The increasing condition of dyspepsia can cause various health problems such as decreasing quality of life and functional activity. Dyspepsia usually affects those of productive age.
Objectives: This article was produced with the intention of examining the association between eating behaviors and the prevalence of dyspepsia in adolescents.
Methods: This is a qualitative article written using a literature study through searches on Google, Google Scholar and Research Gate with the keywords “Eating Patterns and Dyspepsia”, “Types and Frequency of Eating and Dyspepsia”, and “Risk Factors for Dyspepsia”. The resulting articles were selected using the PRISMA flowchart.
Results: There are still many teenagers who do not take care of their own health. Teenagers who still live with their parents sometimes still don't care about their health. Adolescents' eating habits, such as eating irregularly or experimenting with an unbalanced diet that is not recommended by health professionals, can lead to unfulfilled nutritional needs.
Conclusions: Today's lifestyle of teenagers influences their eating habits. Teenagers who are preoccupied with schoolwork and other activities often delay eating or apply the wrong diet, which if left unchecked can trigger dyspepsia. There is a need for repeated education about the importance of fulfilling nutritional intake through regular eating habits to reduce dyspeptic symptoms.
Reliability-based design optimization for seismic structures considering randomness associated with ground motions
Authors: Shrestha Subik , Peng Yongbo
Published: November 2023

When addressing the dynamic reliability analysis of structures, it becomes necessary to account for multiple limit state functions or their combinations. In scenarios where structures are subjected to random excitation, this can lead to intricate inter-dependencies among different limit states, and the computational workload can pose a substantial challenge in ensuring sufficient precision. Code-based design primarily ensures safety at the member level, while deterministic optimization fails to accommodate the inherent uncertainties associated with external excitation or the system as a whole. Therefore, in such cases, to address both the uncertainties in excitations and the presence of multiple limit states while mitigating computational challenges, equivalent extreme-value criteria are employed within the framework of the probability density evolution method to calculate the global reliability of the structure subjected to stochastic ground motions generated from the physically motivated stochastic ground motion model. Numerical optimization is subsequently conducted using genetic algorithms, aiming to minimize the cost of the superstructure while adhering to the design performance criteria related to the inter-story drift ratio and considering global reliability. Additionally, multi-objective optimization is carried out using NSGA-II, permitting the generation of multiple solutions, from which one can select the most suitable solution as needed. The numerical results illustrate the effectiveness of this technique in achieving an optimal balance between the cost of the structure and the consideration of global reliability, providing a comprehensive solution for dynamic reliability analysis and design optimization of structures under random excitations.
Event-triggered consensus control method with communication faults for multi-UAV
Authors: Guo Zilong , Wei Chen , Shen Yankai , Yuan Wanmai
Published: November 2023

This paper investigates the event-triggered consensus for a group of unmanned aerial vehicles (UAVs) with communication faults under the assumption that the position sensors of some individuals are damaged. The objective is to make the UAV group reach consensus in urgent tasks such as obstacle avoidance or evasion. Using the Lyapunov stability theory, sufficient conditions to achieve system consensus are given based on different velocity and position interaction topologies. Considering the limited capabilities of sensors and processors, an event-triggered consensus protocol is adopted to reduce the sampling frequency. Finally, simulation results illustrate the effectiveness of our approach.
TÜRKİYE’DEKİ PSİKOBİYOGRAFİ ÇALIŞMALARI: SİSTEMATİK DERLEME
Authors: KARSLI Feyza
Published: November 2023

Psikobiyografi uzun yıllardan beri var olan ve son yıllarda dünyada artan ilgiye sahip bir konu haline gelmiştir. Psikobiyografilere artan ilgi, bu çalışmaların nasıl yürütüleceği sorusunu gündeme getirmiş, metodolojik açıklamalara öncü olduğu görülmüştür. Özünde psikobiyografi çalışmaları tarihsel öneme sahip olan kişilerin hayatlarının psikoloji kuramları çerçevesinde ele almasını içermektedir. Bu çalışmanın amacı, tarihsel öneme sahip kişinin hayatını psikolojik açıdan sosyo-kültürel bağlamda ele alan Türkiye’deki psikobiyografi çalışmalarını sistematik olarak incelemektir. Ülkemizdeki çalışmalar incelendiğinde, Google Akademik, TR Dizini, Dergipark veri tabanları taranmış, yapılan alanyazın taraması sonucunda 170 çalışmaya ulaşılmış ancak çalışmanın amacına uygun 9 çalışma tespit edilmiştir. İncelenen bu çalışmalar çeşitli yönleriyle ele alınmıştır. Sonuç olarak, ülkemizde psikobiyografi çalışmalarının sınırlı olduğu, yürütülen çalışmaların psikobiyografi metodolojisi açısından sınırlılıklar içerdiği, psikobiyografi alanında daha fazla çalışmaya ihtiyacın olduğu görülmüştür. Ayrıca gelecek çalışmalara ortak metodolojik bir dil sağlamaları için psikobiyografi metot kılavuzlarını kullanmalarının ve ele alınacak kuramsal çerçevenin zenginleştirilmesinin alanyazına önemli bir katkı sağlayacağı da düşünülmüştür.
DEĞİŞTİRİLEBİLİR ALANSAL BİRİM PROBLEMİ VE EKONOMİK FAALİYETLERİN MEKÂNSAL YOĞUNLAŞMASI ÜZERİNE BİR DEĞERLENDİRME
Authors: ÖZEL Emrah , DEMİRGİL Hakan
Published: November 2023

Ekonomik birimlerin mekânsal yoğunlaşması, firmaların birbirine yakın konumlanmasıyla elde edilen faydalar, ölçek ekonomilerinden, teknik işgücü havuzundan, düşük nakliye ve iletişim maliyetlerinden ve teknoloji transferlerinden kaynaklanabilir. Ancak, bu yoğunlaşmanın etkili bir şekilde değerlendirilebilmesi ve bölgesel politikaların ekonomik büyüme ve kalkınmaya yönelik etkili bir şekilde geliştirilebilmesi için mekânsal yoğunlaşma ölçümlerinin tutarlı olması gerekmektedir. Bu noktada, mekânsal analizde karşılaşılan bir problem olan değiştirilebilir alansal birim problemine (MAUP) dikkat çekilmektedir. MAUP, toplu verilerin ve idari sınırların kullanılmasından kaynaklanan ve mekânsal analiz sonuçlarını etkileyebilen bir durumu ifade etmektedir. Bu çalışma, literatürde MAUP olarak bilinen bu sorunu ana hatlarıyla ortaya koymakta, önerilen çözüm yollarına vurgu yapmakta ve ekonomik faaliyetlerin yoğunlaşma ölçümlerinde MAUP etkilerini değerlendirmektedir. Genel bir değerlendirme yapıldığında, MAUP etkilerini azaltmak için sınırlandırılmamış bir mekânsal yapı ve bireyselleştirilmiş mekânsal verilerin kullanımının önemli olduğu sonucuna varılabilir. Ayrıca, ekonomik faaliyetlerin mekânsal yoğunlaşması ile ilgili çalışmalarda, kümelenmeye dayalı göstergeleri kullanan yaklaşımların MAUP'u dikkate almadığı, mesafeye dayalı yaklaşımların ise çeşitli açılardan MAUP etkilerini minimize ettiği belirtilmektedir.
Gender Equality in the Agricultural Sector: Lessons Learned from the Baduy Indigenous Community in Indonesia
Authors: Mirajiani
Published: November 2023

The Baduy people are one of the indigenous communities living in Indonesia at present. The community upholds traditional ways of life based on a customary construction whose application is preserved to date. The study aims to analyse the gender system in the Baduy indigenous community through a qualitative approach, especially in the agricultural field. The research results indicate a division of responsibilities in relation to scope, roles, work, access, control of kinship relationships, marriage patterns, and inheritance patterns between women and men in the community from both productive and domestic perspectives. These differences, however, were not observed to lead to inequality since the system’s value derives from the Baduy community’s cultural construction that guarantees, maintains, and protects gender equality. Moreover, the present study shows us that traditionality is not a factor of gender inequality; traditional cultural constructions have their own mechanisms to create gender equality.
Human Trafficking: A Call for Action Research
Authors: Bhattacharyya Rituparna
Published: November 2023

Since the year 2000, 25 November has been observed as International Day for the Elimination of Violence against Women to make the public aware of violence against women and girls (VAWG). Human Trafficking is one of the most brutal forms of VAWG. This brief communication in the form of an editorial discusses the despicable issues linked to human trafficking, calling for action research.
Educar es cuestión de actitud
Authors: Jacobo Loya Karla Yesenia
Published: November 2023

No se puede educar sin una buena actitud que permita que el instante que se produce en el encuentro del sujeto-objeto, docente-estudiante en el proceso enseñanza-aprendizaje, sea fructífero. Si lo que hoy es el resultado de algo que no funciona del todo, se debe reformular la estrategia y un buen punto de partida es revisar “cómo” está la actitud en estos dos actores. Es momento de reflexionar no solo en lo académico, sino también en el camino de lo emocional, ya que este mismo configura nuestro yo, nuestra personalidad, latente en toda relación social, considerando la educativa.
Competencias esperadas en el joven maestro mexicano. Práctica docente e identidad
Authors: Sandoval Gutiérrez Fernando
Published: November 2023

El texto enlista cuatro categorías que desde El paradigma de la educación para la calidad de vida deben ser fomentadas en los programas de formación de docentes de pregrado, y en los maestros recién llegados al servicio profesional: competencias actitudinales, competencias relacionadas con el manejo de las relaciones interpersonales, competencias para la interacción con el niño y el manejo de los grupos escolares, y finalmente competencias para la higiene mental. Se plantean estas dimensiones formacionales como antecedentes de las competencias para enseñar, inherentes a la práctica docente cotidiana.
Carta del Editor
Authors: Islas Salinas Patricia
Published: November 2023

En la actualidad, en un mundo globalizado de fenómenos pospándemicos, se hace necesario el análisis de la práctica docente para enfrentar la evolución de los procesos de enseñanza y aprendizaje en las comunidades académicas. Las nuevas tendencias indican que ya no es suficiente abordar el currículo de una manera literal, sino que las y los maestros deberán de formarse y capacitarse para atender asuntos de educación socioemocional, aprendizaje activo y estilos de aprendizaje, para proporcionar a los estudiantes nuevas guías de aprendizaje y apoyarlos en la resolución de problemas inherentes a su andar cotidiano en las diferentes esferas que conforman su vida.
BIOMOLECULAR ACTIVITY OF CRYPTOCOCCUS DURING CRYPTOCOCCOSIS: FOCUS ON REVIEW OF MOLECULAR INTERACTION CRYPTOCOCCUS WITH HUMAN IMMUNE SYSTEM AND BLOOD-BRAIN BARRIER
Authors: Julian Julian , Adawiyah Robiatul , Wahdini Sri
Published: November 2023

Global mycosis is still a problem. One of these is the cryptococcal disease. A systemic mycosis brought on by Cryptococcus is called cryptococcosis. Host immunological conditions influence infection with Cryptococcosis. When environmental spores are inhaled by the host, the spores get to the lungs, an infection is created. Alveolar macrophages and other immune cells recognize Cryptococcus in the lung. The initial line of defense against pathogens in the phagolysosome is provided by alveolar macrophages found in the lungs. When the immune system is weak, Cryptococcus uses the evasion system as a molecular interaction with the immune system and persists in the lungs without causing any symptoms such as Factor Transcription, Cell masking, N-glycan structure, Extracellular molecule, and Antioxidant system. The evasion mechanism protects and makes Cryptococcus disseminate throughout the other organs, especially CNS. If Cryptococcus escapes against the host immune system, it will disseminate to other organs, especially Cerebrospinal System by Three mechanisms. There are Trojan Horse, Paracellular, and Transcellular interactions with Blood-Brain Barrier. Disease severity is determined by the Interaction between the host’s immune system and the fungus
Research on the Network Construction Technology of Scientific Knowledge Graph Based on Unequal Weight and Preference Link
Authors: lou Hongli , chen Jianwen
Published: November 2023

Software tools for scientific knowledge graph analysis such as CiteSpace and VOSviewer are widely used by scholars for collaboration analysis, co-occurrence analysis, citation analysis, coupling analysis, and co-citation analysis of research topics. However, these traditional software tools tend to focus on the visual effects of network graphs, and the algorithms used for node relationship weighting and network dynamic structure are too rough, resulting in significant deviations in timeliness and accuracy of calculation results. In this paper, we redesign the edge weight calculation method using proportional counting and Euclidean distance, and study the growth of networks based on the idea of preferential links. Besides, we further optimize new methods for obtaining hot topics and frontiers trends in the current software. Empirical results show that our method has significant advantages in terms of calculation accuracy and can be used as a solution for personalized programming research of knowledge graphs by using Python and other programming languages.
Influence of structural torsional degree of freedom on nose landing gear shimmy
Authors: Ding Jianbin , Feng Guang , Liu Panglun , Yuan Li , Jiang Yiyao , Jiang Bingyan
Published: November 2023

The structural characteristic of combining a maneuvering mechanism and a shimmy damper into a single component is present in the nose landing gear of large civil aircraft. Establishing a more accurate shimmy model based on this property is crucial. The three torsional degrees of freedom shimmy of the nose landing gear was mathematically and physically modeled. The time domain curve, spectrum diagram, and bifurcation diagram were used to compare the three torsional degrees of freedom shimmy model and the single torsional degrees of freedom shimmy model. The three-torsional freedom model predicts a greater amplitude and a longer convergence time in comparison to the findings of the single-torsional freedom model. The sliding tube's torsional vibration frequency falls from 10.9Hz to 8.1Hz in the three-torsional degree-of-freedom model, while the structure's lateral vibration frequency stays the same. The three-torsional freedom model predicts a decrease in the region of stable and torsional shimmy and an increase in the area of lateral and quasi-periodic shimmy. The amplitudes of all degrees of freedom in the three torsional degrees of freedom model, regardless of whether it is torsional or lateral, are greater than those in the single torsional degrees of freedom model when the vertical load is fixed. By increasing the torsional degrees of freedom of the shimmy damper and the main fitting, the inertia, stiffness, and damping in the torsional direction are redistributed in the three-torsional shimmy vibration model, which reduces the stability of the system.
Steroid hormone-induced wingless ligands tune female intestinal size in Drosophila
Authors: Zipper Lisa , Murtra Bernat Corominas , Reiff Tobias
Published: November 2023

Female reproduction comes at great expense to energy metabolism compensated by extensive organ adaptations including intestinal size. Upon mating, Drosophila ovaries release the steroid hormone Ecdysone that stimulates a 30% net increase of absorptive epithelium by intestinal stem cell (ISC) divisions. Here, we uncover the transcription factor crooked legs (crol) as intraepithelial coordinator of Ecdysone-induced ISC mitosis by establishing Rapport, the first spatiotemporally-controlled dual expression and tracing system for the analysis of paracrine effects on ISC behaviour. Rapport tracing revealed that Ecdysone-induced Crol controls mitogenic Wnt/wg-ligand release from epithelial enterocytes towards ISC, which is counterbalanced by Crol-repression of string/CDC25 and Cyclin-B directly in ISC. Rapport-based ISC tumours confirm paracrine stimulation through the Ecdysone-Crol-Wg axis on mitotic behaviour. Finally, mathematical modelling corroborates increasing enterocyte numbers and Wnt/wg-degradation to set a stable post-mating intestinal size. Together, our findings provide insights into complex endocrine growth control mechanisms during mating-induced adaptations and gastrointestinal cancer.
Coupled Natural and Institutional Systems: A Twenty Year Study of the Changing Institutional Complexity of Wildfire
Authors: Nowell Branda , Jones Kate , McGovern Shannon
Published: November 2023

Wildfires are one of the signature threats of climate change and scientists have devoted considerable attention to documenting the biophysical linkages between climate and wildfire. However, we know far less about the linkage between the changing environment and its implication for the human institutions with responsibility to respond to these changes. Institutional complexity is an important concept for advancing climate science as it creates the conceptual linkage between a changing biophysical environment and associated changing institutional task environment. Despite its importance for understanding needs for institutional adaptation, our knowledge of the institutional dimensions of wildfire and its interactions with the changing environment remains relatively nascent. In particular, we know little about where pressures for institutional adaptation are most acute. Effective institutional adaptation is understood as readiness to meet the demands of the new task environment. However, during times of change, institutions may struggle to re-align logics to reflect the demands of the new task environment, particularly if those changes are not well understood. In this paper, we developed and present findings from a novel dataset compiled to understand the evolution of wildfire in the United States from 1999- 2020 in terms of patterns of change in the institutional complexity of wildfire response. Findings reveal national trends of increasing institutional complexity of wildfire in indicators associated with wildfire governance, logistics, management, resource scarcity, and network coordination. However, findings also reveal substantial variation across regions.
What Works in Implementing Shared Medical Appointments for Patients with Diabetes in Primary Care: A Qualitative Comparative Analysis from the Invested in Diabetes Study
Authors: Holtrop Jodi Summers , Gurfinkel Dennis , Nederveld Andrea , Reedy Julia , Rubinson Claude , Kwan Bethany Matthews
Published: November 2023

Background
Diabetes is a serious public health problem affecting 37.3 million Americans. Diabetes shared medical appointments (SMAs) are an effective strategy for providing diabetes self-management support and education in primary care. However, practices delivering SMAs experience implementation challenges. This analysis examined conditions associated with successful practice implementation of diabetes SMAs in the context of participation in a pragmatic trial.
Methods
Mixed methods study using qualitative and quantitative data collected from interviews, observations, surveys, and practice-reported data, guided by the practical, robust implementation and sustainability model (PRISM). Data were analyzed using qualitative comparative analysis (QCA). Successful implementation was defined as meeting patient recruitment targets (Reach) during the study period. Participants were clinicians and staff members from 22 primary care practices in Colorado and Missouri, USA.
Results
The first necessary condition identified from the QCA was the presence of additional resources for patients with diabetes in the practice. Within practices that had these additional resources, we found that a sufficiency condition was the presence of an effective key person to make things happen with the SMAs. A second QCA was conducted to determine conditions underlying the presence of the effective key person (often performing functions of an implementation champion), which revealed factors including low or managed employee turnover, a strong baseline practice culture, and previous experience delivering SMAs.
Conclusions
Identification of key factors necessary and sufficient for implementation of new care processes is important to enhance patient access to evidence-based interventions. This study suggests that practice features and resources have important implications for implementation of diabetes SMAs. There may be opportunities to support practices with SMA implementation by enabling the presence of skilled implementation champions.
Trial registration
Registered at clinicaltrials.gov under trial ID NCT03590041, registered on July 18, 2018
Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19
Authors: Jie Sun , Narasimhan Harish , Cheon In Su , Qian Wei , Hu Shengen , Parimon Tanyalak , Li Chaofan , Goplen Nicholas , Wu Yue , Wei Xiaoqin , Son Young Min , Fink Elizabeth , Santos Gislane , Tang Jinyi , Yao Changfu , Muehling Lyndsey , Canderan Glenda , Kadl Alexandra , Cannon Abigail , Young Samuel , Hannan Riley , Bingham Grace , Arish Mohammad , Chaudhari Arka Sen , Sturek Jeffrey , Pramoonjago Patcharin , Shim Yun , Woodfolk Judith , Zang Chongzhi , Chen Peter
Published: November 2023

The long-term physiological consequences of SARS-CoV-2, termed Post-Acute Sequelae of COVID-19 (PASC), are rapidly evolving into a major public health concern. The underlying cellular and molecular etiology remain poorly defined but growing evidence links PASC to abnormal immune responses and/or poor organ recovery post-infection. Yet, the precise mechanisms driving non-resolving inflammation and impaired tissue repair in the context of PASC remain unclear. With insights from three independent clinical cohorts of PASC patients with abnormal lung function and/or viral infection-mediated pulmonary fibrosis, we established a clinically relevant mouse model of post-viral lung sequelae to investigate the pathophysiology of respiratory PASC. By employing a combination of spatial transcriptomics and imaging, we identified dysregulated proximal interactions between immune cells and epithelial progenitors unique to the fibroproliferation in respiratory PASC but not acute COVID-19 or idiopathic pulmonary fibrosis (IPF). Specifically, we found a central role for lung-resident CD8+ T cell macrophage interactions in maintaining Krt8hi transitional and ectopic Krt5+ basal cell progenitors, thus impairing alveolar regeneration and driving fibrotic sequelae after acute viral pneumonia. Mechanistically, CD8+ T cell derived IFN-γ and TNF stimulated lung macrophages to chronically release IL-1β, resulting in the abnormal accumulation of dysplastic epithelial progenitors and fibrosis. Notably, therapeutic neutralization of IFN-γ and TNF, or IL-1β after the resolution of acute infection resulted in markedly improved alveolar regeneration and restoration of pulmonary function. Together, our findings implicate a dysregulated immune-epithelial progenitor niche in driving respiratory PASC. Moreover, in contrast to other approaches requiring early intervention, we highlight therapeutic strategies to rescue fibrotic disease in the aftermath of respiratory viral infections, addressing the current unmet need in the clinical management of PASC and post-viral disease.
Diversity in Lacrimal Pathway Morphology among Japanese Patients with Congenital Nasolacrimal Duct Obstruction
Authors: Nakamura Jutaro , Ohno Tomoko , Asano Mizuki , Takeuchi Masaki , Mizuki Nobuhisa , Matsumura Nozomi
Published: November 2023

Objective:
This prospective observational study aimed to explore the diversity in lacrimal pathway morphology among patients with congenital nasolacrimal duct obstruction (CNLDO) by examining dacryocystography (DCG) images.
Methods:
The study included 64 patients who underwent DCG before undergoing general anesthesia probing for unilateral CNLDO. Several parameters were measured from the sagittal section DCG images: (1) the angle between the lacrimal sac (LS) and the nasolacrimal duct (NLD), (2) the angle between the superior orbital rim, the center of the LS, and the NLD, and (3) the length of the LS, (4) the length of the bony NLD. Additionally, the following parameters were measured from coronal section images: (5) the angle formed by the LS and the NLD and (6) the angle formed by the LS concerning the midline.
Results:
The average age of the patients was 34.3 months (range: 14–84 months). The mean ± standard deviation of the measurements of the above parameters was (1) -1.2° ± 16.5° (range: -44.6°–46.6°), (2) -5.0° ± 10.3° (range: -24.0°–19.0°), (3) 10.2 ± 2.4 mm (range: 6.5–16.0 mm), (4) 8.0 ± 2.5 mm (range: 3.1–14.8 mm), and (5) 15.6 ± 11.2° (range: -16.8°–41.0°), (5) 15.1 ± 5.2° (range: 3.3°–29.8°). All parameters, except for parameter (3), conformed to a normal distribution.
Conclusions:
This study provides valuable anthropometric data derived from DCG images, and the results highlight the substantial variability in lacrimal pathway morphology among patients with CNLDO. These findings have the potential to influence both diagnostic and treatment strategies.
What is already known on this topic?
Comprehending the morphology of the lacrimal pathway is crucial for the success of probing in patients with CNLDO. However, studies that delve into the detailed analysis of the lacrimal pathway in pediatric CNLDO are limited.
What this study adds
This study reports the first attempt to measure anthropometric parameters of the lacrimal drainage system in patients with CNLDO using DCG images. Moreover, probing with straight probes was considered anatomically infeasible in 25.0% of cases in the included patients in this study.
How this study might affect research, practice, or policy
The results underscore significant variations in the morphology of the lacrimal drainage system among patients with CNLDO, potentially influencing both diagnostic approaches and treatment strategies. This includes considerations such as conducting an anatomical evaluation of the lacrimal pathway and making informed decisions in selecting probe forms before undertaking procedures.
Company performance under multiple ownership classes.
Authors: Alanazi Ahmed S.
Published: November 2023

We develop a new method of ownership classification and examine the impact of various owners on firm performance. Prior research focuses mainly on managerial ownership and/or a few general classifications (block-holders vs. non-block-holders, institutional vs. non-institutional). No prior studies attempt to model all corporate owners together in one model. This study fills this gap. Our classification divides listed corporations into government, institutional, public, managerial, family, and foreign owners. Analyzing and comparing these companies yields several important findings. First, government and institutional firms perform the best, while public and managerial firms perform the worst. Second, the OLS and simultaneous system 2SLS estimates suggest that government and institutional ownership contribute positively to firm performance, while public ownership has a negative effect. Incorporating the potential endogeneity issue into the system suggests that the relationship is bidirectional, where the causality runs from ownership to performance and vice versa.
JEL: G14, G32, D23, L14
Anesthetic management of patient with large Atrial Septal defect for caesarean delivery in resource limited setting
Authors: Baboker Petros , Demissie Haile
Published: November 2023

Background: Atrial septal defect (ASD) is one of the common cardiac problems in adults most commonly in females. It complicates the management by increasing load on right heart chamber and pulmonary vasculatures. This leads to hypoxemia, hypercarbia, arrhythmias and congestive heart failure.
Case presentation: Here we report successful management of a 27-year- old prim gravida woman at 38 weeks of gestation diagnosed with large ASD with the defect of 16.2mm on Echocardiogram undergoes elective caesarean section. The procedure was done with low dose spinal anesthesia.
Conclusion: No complications were encountered during perioperative period. Spinal anesthesia is safe for patients with atrial septal defect undergoing caesarean delivery.
Predicting sepsis within 24 hours at triage stage in emergency department using machine learning
Authors: Xie Jingyuan , Zhang Ting , Gao Jiandong , Liu Yecheng , Chen Yutong , Yang Mutian , Liu Zetong , Mei Qimin , Li Zhimao , Zhu Huadong , Wu Ji
Published: November 2023

Background
Sepsis is one of the main causes of mortality in intensive care units. To reduce its damage, prediction should be made the earlier the better. As around 36% of sepsis onset took place within 24 hours after ED admission in MIMIC-IV (v2.2), a prediction system at ED triage stage would certainly be of help. Previous methods, such as qSOFA, are more suitable for screening instead of prediction in ED. And we aimed to find a light-weight, convenient prediction method through machine learning.
Methods
We utilized the open medical database MIMIC-IV (v2.2), to obtain sepsis patients’ corresponding data in the emergency department. We built our dataset with demographic data, vital signs and synthesized features. We used XGBoost as the classifier, to predict if the patient would develop sepsis within 24 hours after ED admission, and used SHAP to interpret the model’s outcome.
Results
For 10 fold cross validation on the 14,957 samples, we reached an accuracy of 84.1 ± 0.3%, and an area under the ROC curve of 0.92 ± 0.02. The model achieved similar performance on the testing set of 1,662 patients. SHAP values showed that the five most important features were acuity, arrival transportation, age, shock index, and respiratory rate.
Conclusions
Machine learning models like XGBoost can be used for sepsis forecast, using just a small amount of data conveniently collected in the ED triage stage. This can help reduce the workload in the ED, and warn medical workers against the risk of sepsis in advance.
Causal associations between human gut microbiota and osteomyelitis: a mendelian randomization study
Authors: Zeng WenXing , Wu YuHang , Cun DeJun , Ma Luyao , Zhang JingTao , Hang Feng , Jiang Ziwei
Published: November 2023

Background: Recent studies have illuminated the potential association between gut microflora and osteomyelitis. Despite these advancements, the underlying causal relationship remains elusive.
Methods: In this research, we utilized the largest genome-wide association study (GWAS) meta-analysis available from the MiBioGen consortium to date (n=13,266) and employed a two-sample Mendelian randomization study (TSMR) framework. We conducted a detailed investigation into the causal relationship between gut flora and osteomyelitis using inverse variance weighting, MR-Egger, weighted median, and weighted modeling approaches. Additionally, Cochran's Q statistic was applied to measure the heterogeneity of the instrumental variable (IV).
Results：Our study demonstrated that an increased abundance of Bacilli, Bacteroidia, Bacteroidales, Butyricimonas, Coprococcus3, and Tyzzerella3 was positively associated with the risk of osteomyelitis, while Lachnospira was negatively associated. Sensitivity analyses revealed no evidence of heterogeneity or pleiotropy.
Conclusion：This study marks the first to provide suggestive evidence of beneficial or detrimental causal effects of gut microbiota on the risk of osteomyelitis through the application of MR methods. These insights may offer critical information regarding the pathogenesis of gut flora-mediated osteomyelitis and inform strategies for its prevention and treatment.
The burdens of low-value care in hysterectomy attributable to hospital ownership in China
Authors: Pan Jay , Luo Huijia , Lan Tianjiao , Coyte Peter , Ju Ke
Published: November 2023

Scholarly attention has been dedicated to the identification of low-value care (care that is not expected to provide a net benefit). Despite a consensus on the importance of hospital characteristics in explaining the use of low-value care, the precise influence of hospital ownership, herein the distinction between public and private ownership, remains unclear. This study included 38,865 hospital discharge records with hysterectomy procedures in China from 2016 to 2020 to describe the effect of public and private hospital ownership on the provision of low-value care and estimate the attributable risk ratio and corresponding attributable burden. Private hospitals were more likely to provide low-value hysterectomies, with the average incremental effect of 33.7% (95% CI, 23.5–42.5%). Potential interventions in private hospitals could reduce this a maximum of 9.7% (95% eCI, 8.7–10.4%) of low-value hysterectomy cases, corresponding to 48,375 (95% eCI, 43,254, to 51,706) annual cases and 1.82 (95% eCI, 1.63 to 1.94) billion USD costs nationally. For the first time, we identified the potential intervention target and estimated the maximum effectiveness of interventions to eliminate excessive risk of low-value care.
Motor and Perceptual Tests of the Preferred Period Hypothesis: A Cross-Sectional Study
Authors: Rioux Pier-Alexandre , Grondin Simon
Published: November 2023

The preferred period hypothesis posits a slowing down of motor and perceptual rhythmic preferences with age, both reflecting an increase in the common internal oscillation period. This study further investigates the preferred period hypothesis by enhancing the measurement of perceptual rhythmic preferences. Two tasks were used to measure perceptual rhythmic preferences, in addition to extending the latter to the visual modality. The study was conducted with three groups of children (5–6, 8–9, and 11–12 years old), and a group of young adults (21 to 30 years old) during the same time of the day. Correlational analyses show that the relationship between motor and perceptual rhythmic preferences strengthens between childhood and adulthood. Multilevel analyses reveal a general slowing down of motor and perceptual rhythmic preferences, contingent on the task and modality, with distinct trajectories for males and females. Our study indicate that the range of preferred rhythms narrows with age, becoming less variable in young adulthood, at the expense of a single and consistent, default rhythm. In brief, the preferred period appears only in young adults, with no support for the idea of a slowing down of an internal oscillation that would be reflected by both motor and perceptual rhythmic preferences.
MiRNA-29b modulates neuroinflammation by targeting T-bet in Experimental Autoimmune Encephalomyelitis mice treated with vitamins A and D
Authors: Mohammadi-Kordkhayli Marziyeh , Mansouri Fatemeh , Saboor-Yaraghi Ali Akbar , Noorbakhsh Farshid
Published: November 2023

Objective: Vitamins A and D are modulators of inflammatory responses, and their deficiency is associated with autoimmune diseases including multiple sclerosis (MS). we investigated the correlation between treatment with vitamins A/D, differentiation of Th1 cells in EAE mice and the role of miR-29a/b.
Methods: EAE was induced in C57BL/6 mice. Animals were treated with vitamin A, D and A+D. We measured the expression of miRNAs and their target genes in the CNS and lymphocytes of treated mice by RT-PCR. Th1 cell Percentages was measured in splenocytes utilizing intracellular staining and flow cytometry. To examine the role of miRNAs in leukocyte differentiation and function, miR-29b mimic sequences were transfected into cultured purified CD4+ T cells which analyzed by flow cytometry.
Results: The expression levels of T-bet reduced and increased levels of miR-29a/b-3p in the spinal cords and splenocytes of vitamin A and D treated EAE mice compared with EAE mice. The percentage of Th1 cells decreased in splenocyte from mice treated with vitamins A and D. miR-29b mimic sequences suppressed Th1 production in CD4+ T cells.
Conclusion: A and D diminish neuroinflammation in EAE by increasing the expression of miR-29b-3p, which acts as an inhibitor of CD4+ T cell differentiation to IFN-γ-producing Th1 cells.
Unveiling antibiotic resistance, clonal diversity, and biofilm formation in E. coli for safer pork production
Authors: Silva Vanessa , Dapkevicius Maria de Lurdes Enes , Azevedo Mónica , Cordeiro Rui , Valentão Patricia , Falco Virgilio , Igrejas Gilberto , Caniça Manuela , Poeta Patricia
Published: November 2023

Escherichia coli, a commensal microorganism found in the gastrointestinal tract of human and animal hosts, plays a central role in agriculture and public health. Global demand for animal products has promoted an increase in pig farming, leading to growing concerns about the prevalence of antibiotic-resistant E. coli strains in swine populations. It should be noted that a significant portion of antibiotics deployed in swine management belong to the critically important antibiotics (CIA) class, which should be reserved for human therapeutic applications. This study aimed at characterizing the prevalence of antibiotic resistance, genetic diversity, and virulence characteristics of E. coli strains isolated in different pig farms in Portugal. Our study revealed high levels of antibiotic resistance, with resistance to tetracycline, ampicillin, tobramycin, and trimethoprim-sulfamethoxazole. Multidrug resistance is widespread, with some strains showing resistance to seven different antibiotics. The ampC gene, responsible for broad-spectrum resistance to cephalosporins and ampicillin, was widespread, as were genes associated with resistance to sulfonamide and beta-lactam antibiotics. The presence of high-risk clones, such as ST10, ST101 and ST48 are a concern due to their increased virulence and multidrug resistance. Regarding biofilm formation, it was observed that biofilm-forming capacity varied significantly across different compartments within pig farming environments. In conclusion, our study highlights the urgent need for surveillance and implementation of antibiotic management measures in the swine sector. These measures are essential to protect public health, ensure animal welfare and support the swine industry in the face of the growing global demand for animal products.
Fractional abstract Boussinesq equations and applications
Authors: Shakhmurov Veli , Shahmurov Rishad
Published: November 2023

In this paper the existence, uniqueness and regularity properties to solution of the Cauchy problem for the fractional abstract Boussinesq equation is obtained. First, we consider the linear Boussinesq equation and prove the existence, uniqueness and the regularity properties of solutions. It can be used to obtain the existence and uniqueness of the regular solution of corresponding nonlinear Boussinesq equation. By applying this result, the Cauchy problem for finite or infinite systems of Boussinesq equations is studied.
Association between muscle-fat ratio and sarcopenia in older adults with hypothyroidism
Authors: yang ruixia , pan youzhuo , lei haoyue , guo wenhui , wen ziying , yang fan , zhang qi
Published: November 2023

Objectives To test the body composition To investigate the associationbetween body fat (BF%)，muscle-fat ratio and sarcopenia in older adults with hypothyroid。
Methods A total of 543 older adults with hypothyroidism were included in this cross-sectional study. Appendicular skeletal muscle (ASM), handhandgrip strength and gait speed were measured to diagnose sarcopenia according to the updated Asian Working Group for Sarcopenia (AWGS) 2019 criteria. Body composition data were tested using a bioresistive antibody composition analyzer (model: Tsinghua Tongfang BCA-2A).Levels of serum Lipids and thyroid hormone were also determined.
Results The prevalence of sarcopeniain all participants was 25.51%, of which 18.58% were male and 31.54% females. The Pearson’s correlation analysis revealed that BF% was positively correlated with ASMI in both male and female patients (R=0.530, P=0.001; R=0.649, P=0.001), and positively correlated with handhandgrip strength in males and gait speed in females (R=0.230, P=0.014; R=0.242, P=0.005). Muscle-fat ratio was negatively correlated with ASMI in both sexes (R=-0.496, P=0.001; R=-0.291, P=0.001) and with handhandgrip strength in male patients (R=-0.327, P=0.001).After adjusting for all potential confounders, sarcopenia was positive associated with BF% (male, OR: 0.805, 95% CI: 0.726-0.894, P< 0.001; female, OR: 0.876, 95% CI: 0.811-0.946, P=0.004), and positive associated with body mass index (BMI) (male, OR: 0.678, 95% CI: 0.570-0.807, P<0.001; female, OR: 0.618, 95% CI: 0.484-0.790, P<0.001).But decreased muscle-fat ratio was a risk factor for sarcopenia(male, OR: 1.975, 95% CI: 1.412-2.763, P<0.001; female, OR: 2.330, 95% CI: 1.280-4.242, P=0.006).No significant differences were found in Lipids, thyroid hormone between older adults with hypothyroidism with and without sarcopenia.
Conclusion older adults with hypothyroidism have a higher risk of sarcopenia,lower BF% and BMI were linked to an increased risk of sarcopenia in older adults with hypothyroidism.suggesting the importance of assessing muscle fat ratio and BF% rather than BMI alone to manage sarcopenia.older adults with hypothyroidism should maintain BMI and BF%, timely detection of body composition and control of muscle fat ratio are important measures for the prevention and treatment of sarcopenia.
Cost-effectiveness of glass ionomer cements in Atraumatic Restorative Treatment
Authors: Silva Rênnis Oliveira da , de Araújo Elza Cristina Farias , Freire Luciana Leônia Soares , Braga Mariana Minatel , Cavalcanti Yuri Wanderley , de Lucena Edson Hilan Gomes
Published: November 2023

Background
High-viscosity glass ionomer cements are the preferred materials for conducting restorations using Atraumatic Restorative Treatment (ART). However, there are more affordable alternatives available in the market that do not possess high viscosity. The objective of this study was to evaluate the cost-effectiveness of Glass Ionomer Cement (GIC) for Atraumatic Restorative Treatment (ART) in deciduous teeth.
Methods
The study conducted an economic analysis of the cost-effectiveness type. The cost of ART was determined using micro-costing techniques, and the survival rates after 1 year (effectiveness) were obtained from existing literature studies. Decision trees were constructed to compare the materials used in ART for both simple and composite cavities, considering the perspective of the local health manager. To estimate the cost-effectiveness of treating 1000 primary teeth, a Monte Carlo microsimulation was performed. The incremental cost-effectiveness ratio (ICER) was used to indicate the additional cost required to increase effectiveness after 1 year. The analyses were conducted using TreeAge Pro software.
Results
Regarding ART in single cavities, Maxxion R (FGM) was found to have a lower cost (BRL 22,945.23), while Ketac Molar (3M ESPE) exhibited greater effectiveness (891.3 teeth). The alternatives FUJI IX (GC America, ICER = 3.12) and Ketac Molar (ICER = 5.27) were considered more cost-effective. For composite cavities, Ketac Molar (ICER = 3.65) was identified as the most cost-effective option.
Conclusion
The study revealed variations in both cost and effectiveness among different materials used in ART. Lower cost may indicate lower effectiveness.