bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of a novel “Split” ventilation system in bench and porcine modeling of acute respiratory distress syndrome
Authors: Geoghegan Pierce , Clarke Jennifer , Hogan Grace , Keogh Aoife , Marsh Hannah , Donnelly Karen , McEvoy Natalie , Doolan Aoife , Madden Stephen F. , Martin‐Loeches Ignacio , Power Michael , Laffey John G. , Curley Gerard F.
Published: September 2022

Split ventilation (using a single ventilator to ventilate multiple patients) is technically feasible. However, connecting two patients with acute respiratory distress syndrome (ARDS) and differing lung mechanics to a single ventilator is concerning. This study aimed to: (1) determine functionality of a split ventilation system in benchtop tests, (2) determine whether standard ventilation would be superior to split ventilation in a porcine model of ARDS and (3) assess usability of a split ventilation system with minimal specific training. The functionality of a split ventilation system was assessed using test lungs. The usability of the system was assessed in simulated clinical scenarios. The feasibility of the system to provide modified lung protective ventilation was assessed in a porcine model of ARDS (n = 30). In bench testing a split ventilation system independently ventilated two test lungs under conditions of varying compliance and resistance. In usability tests, a high proportion of naïve operators could assemble and use the system. In the porcine model, modified lung protective ventilation was feasible with split ventilation and produced similar respiratory mechanics, gas exchange and biomarkers of lung injury when compared to standard ventilation. Split ventilation can provide some elements of lung protective ventilation and is feasible in bench testing and an in vivo model of ARDS.
Fast inference methods for high-dimensional factor copulas
Authors: Verhoijsen Alex , Krupskiy Pavel
Published: September 2022

Gaussian factor models allow the statistician to capture multivariate dependence between variables. However, they are computationally cumbersome in high dimensions and are not able to capture multivariate skewness in the data. We propose a copula model that allows for arbitrary margins, and multivariate skewness in the data by including a non-Gaussian factor whose dependence structure is the result of a one-factor copula model. Estimation is carried out using a two-step procedure: margins are modelled separately and transformed to the normal scale, after which the dependence structure is estimated. We develop an estimation procedure that allows for fast estimation of the model parameters in a high-dimensional setting. We first prove the theoretical results of the model with up to three Gaussian factors. Then, simulation results confirm that the model works as the sample size and dimensionality grow larger. Finally, we apply the model to a selection of stocks of the S&P500, which demonstrates that our model is able to capture cross-sectional skewness in the stock market data.
Invertible matrices over some quotient rings: identification, generation, and analysis
Authors: Vysotskaya Viktoriya V. , Vysotsky Lev I.
Published: September 2022

We study matrices over quotient rings modulo univariate polynomials over a two-element field. Lower bounds for the fraction of the invertible matrices among all such matrices of a given size are obtained. An efficient algorithm for calculating the determinant of matrices over these quotient rings and an algorithm for generating random invertible matrices (with uniform distribution on the set of all invertible matrices) are proposed and analyzed. An effective version of the latter algorithm for quotient rings modulo polynomials of form x

r
− 1 is considered and analyzed. These methods may find practical applications for generating keys of cryptographic schemes based on quasi-cyclic codes such as LEDAcrypt.
Computation of distributions of statistics by means of Markov chains
Authors: Zubkov Andrei M. , Filina M. V.
Published: September 2022

An approach to the construction of efficient algorithms for the exact computation of distributions of statistics by means of the Markov chains is described. The Pearson statistic, the number of empty cells for random allocations of particles, and the Kolmogorov – Smirnov statistic are considered as examples. Possibilities of extending the approach are discussed, in particular to the computation of the joint distributions of statistics.
Energy-saving intelligent manufacturing optimization scheme for new energy vehicles
Authors: Zeng Xianjun , Sun Xiuqian , Zhao Fei
Published: September 2022

With the rapid development of the automobile industry in recent years, China has become a big country of automobile production and consumption. The development of China’s auto industry is currently at an important turning point, and accelerating the development of new energy vehicles has become a major national strategic measure. This research mainly discusses the energy-saving intelligent manufacturing optimization scheme of new energy vehicles. With the rapid growth of the global car ownership, from the perspective of sustainable development, the automobile industry must solve the four major automobile public hazards in the world: energy, pollution, safety and congestion. In view of this, the state regards energy-saving and new energy vehicles as the main strategic direction for the transformation and upgrading of China’s automobile industry. This paper uses industrial engineering theory and lean management concept, and through the application of new intelligent manufacturing mode, realizes the design and manufacture of energy-saving and new energy vehicle lightweight body, and creates a reliable, comprehensive and feasible manufacturing collaborative management MES platform. It solves the problem of integration and interconnection of enterprise information platforms, realizes the intelligence and flexibility of stamping and welding automated production lines, shortens the development cycle, and meets the diverse needs of products. The first is to organize research on lean production theory, analyze the scope of application of theoretical tools, summarize theoretical tools suitable for lightweight intelligent manufacturing of automobiles, and provide theoretical support for lean and intelligent manufacturing research and on-site improvement; the second is to integrate and optimize the production process and process design through quantitative analysis and qualitative analysis, integrating theories such as production takt management and pull production, and analyze and study future on-site improvements, and discuss the lean path of smart factories; the third is to plan and design technical routes such as stamping and welding according to the process flow optimized by digital simulation, propose an overall solution for lean intelligent factory, analyze the advanced and innovative nature of the solution, and compare the comprehensive indicators with the expected goals, to evaluate the research results. During the research process, the energy consumption of output value was reduced by 8% than expected. This research helps to provide new ideas for intelligent manufacturing optimization of new energy vehicles. In the design of the program route of the intelligent manufacturing factory, the concept of lean production is introduced in the whole process, in order to provide a useful reference for similar enterprises in the industry in the application practice of intelligent manufacturing + lean production.
High tone bumping in Runyankore
Authors: Hyman Larry M.
Published: September 2022

In this study I present the unusual properties of a rule of High Tone Bumping (HTB) which occurs in certain languages of the Rutara subgroup of Bantu. By this process, the final H tone of a word or clitic “bumps” a preceding H tone one syllable to the left, e.g. /kaawá=kí/ → kááwa=kí ‘what coffee?’ (as realized utterance-medially). The triggers consist of /H/ CV monosyllables as well as VCV words whose final syllable is /H/. Since these can interact with each other, frequently with V+V vowel coalescence, this produces H tone sequences of trigger-targets in which each H appears to be bumped one syllable to the left. I present the facts of HTB in some detail and offer two synchronic analyses, one involving a left-to-right iterative rule, the other recognizing H*-marked tone spans that can be globally accessed to apply HTB all at once. I conclude by considering possible historical origins of HTB.
Extending !Xun dialect comparisons with a Ju|’hoan variety spoken in |Xae|xae, Botswana: gender classes, plural markers and loanwords
Authors: de Voogt Alex
Published: September 2022

Dialect clusters in Africa and specifically those of Khoisan languages are relatively underdocumented. !Xun can be described as a complex or a cluster of lects and the Ju|’hoan speakers of |Xae|xae, Botswana, are part of the (eastern) E1 dialect cluster of the !Xun language. Their closest neighbors in Tsum!kwe, Namibia, also speakers of Ju|’hoan, have been the subject of extensive linguistic study. A comparison based on lexical items affiliates speakers from |Xae|xae mainly with those from Tsum!kwe but with several exceptions. Additional comparisons between the Tsum!kwe and |Xae|xae speakers based on morphological markers show differences in plural markers and gender classes as well as differences in influences from neighboring languages. This study adds a specific variety to the description of the E1 dialect cluster that should encourage further research on Ju|’hoan as spoken in Botswana.
A Model United Nations Experiment on Climate Negotiations
Authors: Hofmann Elisa , Kyriacou Lucas , Schmidt Klaus M.
Published: September 2022

Weitzman, M.L. (2014. Can negotiating a uniform carbon price help to internalize the global warming externality? J. Assoc. Environ. Resour. Econ. 1: 29–49) proposed that focusing international climate negotiations on a uniform common commitment (such as a uniform carbon price) is more effective than negotiations on individual commitments (as in the Paris agreement) in achieving ambitious climate action. We put this hypothesis to an experimental test by simulating international negotiations on climate change in collaboration with Model United Nations associations. This novel experimental format combines some of the advantages of lab and field experiments. Our results offer support for Weitzman’s hypothesis and indicate that negotiating a common commitment on a uniform carbon price may yield higher emission reductions in the long run and more participation than individual commitments à la Paris.
The Place of Judgments of Perception in Kant’s Transcendental Cognitive Theory
Authors: Lin Cheng-Hao
Published: September 2022

The distinction between judgments of perception and judgments of experience in Kant’s Prolegomena has long been a controversial issue in Kantian studies. On the one hand, this distinction challenges the close connection between the synthetic unity of self-consciousness and the categories. On the other hand, a distinction between the subjective and the objective is unavoidable in our cognitive life. I will show in this paper that the interpretive difficulties arise from the ambiguity of Kant’s use of the concept of perception and his misleading formulation of the judgments of perception. After clarifying these problems and adopting the regulative use of the concept of the I in Kant’s theory of perception, the place of judgments of perception in his transcendental cognitive theory can be clarified, and the consistency of his system can be observed.
Self-Legislating Machines: What can Kant Teach Us about Original Intentionality?
Authors: Evans Richard
Published: September 2022

In this paper, I attempt to address a fundamental challenge for machine intelligence: to understand whether and how a machine’s internal states and external outputs can exhibit original non-derivative intentionality. This question has three aspects. First, what does it take for a machine to exhibit original de dicto intentionality? Second, what does it take to exhibit original de re intentionality? Third, what is required for the machine to defer to the external objective world by respecting the word-to-world direction of fit? I attempt to answer the first challenge by providing a constitutive counts-as understanding of de dicto intentionality. This analysis involves repurposing Kant’s vision of a self-legislating agent as a specification of a machine that reprograms itself. I attempt to answer the second and third challenges by extending Kant’s synchronic model of de dicto intentionality with Brandom’s interpretation of Hegel’s diachronic model of de re intentionality, using Hegel’s notion of recollection to provide an understanding of what is involved in achieving deference to the external world.
Genre and gender at work: the antithesis of man from pictorial analysis in Portuguese advertisements
Authors: Pruekchaikul Korapat
Published: September 2022

This study presents a pictorial analysis of Portuguese advertisements from a visual semiotic perspective, particularly the symbolic attributive and suggestive processes. Aiming to elucidate the relationship between genre and gender, the study explored advertising genre, masculinity in advertisements, and the antithesis of man as primary theoretical concerns. The data consisted of five pictures from Portuguese advertisements. The analysis suggests that advertisements are a textual arena where not only genre but also gender is constructed and modified in collaboration. The image of the antithesis of man coexisting with the one of normative masculinity in the five Portuguese advertisements indicates that genre and gender are mutually and simultaneously fluid, with their boundary often blurred. That advertisements are often prone to changes in their function to attract customers implies new and evolving presentation forms of genre and gender. The combination of new and conventional images of masculinity, as shown in the analysis, impacts social and linguistic practices, particularly the fact that traditional norms of defining genre and gender, despite their resemblant quality, might be occasionally challenged or reconstructed in late-modern culture.
Ecosemiotics and biosemiotics: a comparative study
Authors: Tian Haiqing , Wang Yongxiang
Published: September 2022

Ecological semiotics belongs to the field of culture, and biological semiotics refers to biology. There are both similarities and differences between ecological semiotics (ecosemiotics) and biological semiotics (biosemiotics). “Co-existence and co-prosperity” are the highest true meaning of human beings and nature. Faced with the increasingly serious ecological crisis, human beings, as the only semiotic animal that can reflect on sign activities, are ultimately responsible for other species and the entire ecological community.
Synthesis and crystal structure of 2-(2-oxo-2-(thiophen-2-yl)ethyl)-4H-chromen-4-one, C15H10O3S
Authors: Chen Yang , Xiao Tao , Liu Feng , Yan Xiaolong
Published: September 2022

C15H10O3S, monoclinic, P21/c (no. 14), a = 12.391(5) Å, b = 21.034(8) Å, c = 10.777(4) Å, β = 113.589(7)°, V = 2574.1(16) Å3, Z = 8, R

gt
(F) = 0.0704, wR

ref
(F
2) = 0.1988, T = 296(2) K.
Erfassung von Indikationsqualität mithilfe von GKV-Routinedaten
Authors: Vogt Verena , Busse Reinhard , Dammertz Lotte , Ermann Hanna , Ihle Peter , Nothacker Monika , Pioch Carolina , Reichebner Christoph , Schneider Udo , Swart Enno
Published: September 2022

Erhalten Patient*innen Gesundheitsleistungen, die nicht indiziert sind, kann dies mit Fehldiagnosen und überflüssigen Folgeuntersuchungen einhergehen und sowohl die Patient*innen als auch das Gesundheitssystem unnötig belasten. Das Monitoring nicht indizierter Versorgung bzw. der Indikationsqualität kann Handlungsbedarfe identifizieren, um Verbesserungsinitiativen zu entwickeln. Dieser Beitrag stellt mögliche Ansätze zur Messung von Indikationsqualität mit GKV-Routinedaten vor und geht auf die mit der Messung verbundenen Chancen und Herausforderungen ein.
Migrationshintergrund und Inanspruchnahme medizinischer Leistungen
Authors: Grochtdreis Thomas , König Hans-Helmut , Dams Judith
Published: September 2022

Ein Migrationshintergrund kann als individueller prädisponierender Faktor für die Inanspruchnahme von medizinischen Leistungen betrachtet werden. Es gibt einen negativen Zusammenhang zwischen einem direkten Migrationshintergrund und der Inanspruchnahme von hausärztlicher und fachärztlicher Versorgung sowie der Hospitalisierung. Der Zugang zur Gesundheitsversorgung von Menschen mit direktem Migrationshintergrund sollte durch gesundheitspolitische Maßnahmen vermehrt adressiert werden.
Finanzierung von stationärer Langzeitpflege
Authors: Kalwitzki Thomas , Rothgang Heinz
Published: September 2022

Die Finanzierung von stationärer Langzeitpflege umfasst in Deutschland mehrere Entgeltbestandteile. Nur pflegebedingte Kosten werden bis zu einer pauschalen Höhe von der Pflegeversicherung getragen. Alle weiteren Kosten sind von den Pflegebedürftigen privat oder subsidiär durch die Sozialhilfe aufzubringen. Da Eigenanteile regelmäßig die Alterseinkünfte übersteigen, bietet die Pflegeversicherung aktuell keine ausreichende Absicherung gegen pflegebedingte Sozialhilfeabhängigkeit.
Betriebliche Gesundheitsförderung: Ein leeres Versprechen?
Authors: Auer Thorsten , Sennefelder Lisa , Meier Heiko
Published: September 2022

Unternehmen investieren zunehmend in Angebote Betrieblicher Gesundheitsförderung (BGF). Dabei stellt sich die Frage nach dem Kosten-Nutzen-Verhältnis jenseits des individuellen Nutzens durch die Förderung der Mitarbeitergesundheit. Deshalb wurden im Rahmen einer Sekundäranalyse Effekte der BGF auf den Unternehmenserfolg berechnet. Die Ergebnisse lassen vermuten, dass sich eine verhaltensorientierte BGF kaum positiv auf die Arbeitsproduktivität und Kommunikationsstruktur in Unternehmen auswirkt.
The effect of magnesium doping concentration on the structural and optical properties of zinc oxide nanoparticles
Authors:   Department of Physics Federal Urdu University of Arts, Science and technology Karach, Pakistan, Nazar M. S. , Mishal U. ,   Department of Physics, University of Karachi, Pakistan, Khalid M. ,   Department of Physics, University of Karachi, Pakistan, Fazil P. ,   Department of Chemistry, University of Karachi, Pakistan, Rahim M. ,   Department of Basic Sciences, DHA Suffa University, Karachi, Pakistan.
Published: September 2022

In this study, the optical and structural properties of Magnesium doped Zinc Oxide (Zn1-xMgxO) nanoparticles (x = 1%, 3%, and 5%) were examined. The synthesis was carried out at 300 oC by using a simple co-precipitation method. The structural samples were used to characterize the synthesized nanoparticles by using Scanning Electron Microscopy (SEM) and X-Ray Diffraction (XRD). Energy Dispersive X-Ray spectroscopy (EDX) was used to determine the chemical composition of the samples. Furthermore, UV-Vis spectroscopy was conducted to study our samples’ optical characteristics. As per XRD analysis, both pure and Mg doped ZnO samples possess wurtzite structure. The particle size was revealed to decrease significantly with Mg concentration, from 36 nm for pure sample to 23.87 nm with 5% Mg. In comparison to ZnO, the XRD pattern of Mg-doped ZnO shows a peak shift towards lower 2θ values. As a result of deformation of crystal structure caused by integrated Mg+2 ions onto Zn+2 sites. SEM images of synthesized samples reveal that the nanoparticles possess sheet, spherical and rod like morphologies for different values of x. The EDX analysis verifies the purity of samples within the detection limits. According to optical absorption spectra obtained from UV-Visible spectroscopy in the 200nm to 1000nm range affirmed that as Mg concentration increased, the band gap increased from 3.37 eV for pure sample to 3.74 eV with 5% Mg. The UV-Visible spectra of pure ZnO and Mg-doped ZnO samples also exhibit distinct peaks in the UV region at 335 nm, 311 nm, 310.6 nm, and 310 nm. Across the spectra of pure and Mg-doped ZnO samples, the UV peak is attributed to free exciton transitions, whereas, in the spectra of Mg-doped ZnO UV absorbance peak in the visible region is attributed to the radiative transitions of electrons captured at oxygen vacant sites with holes trapped at singly ionized oxygen vacancies.
Histopathological evaluation of the effects of thymoquinone and resveratrol on the liver in rats administered doxorubicin
Authors: Ates Mehmet Burak , Ozdemir Ozgur , Ozturk Ali Erdem , Bucak Mustafa Numan , Bulut Aysegul
Published: September 2022

Amaç: Ratlarda doksurubisin kaynaklı hepatotoksisite üzerine farklı dozlardaki timokinon ve resveratrolün (5 and 20 mg/kg) etkilerinin patolojik olarak değerlendirilmesi amaçlandı.
Gereç ve Yöntem: Çalışmada 80 erkek Wistar Albino rat kullanıldı. Hayvanlar, kontrol (C, Fizyolojik tuzlu su, PO); doksorubisin (Fizyolojik tuzlu su, PO ve 10. günde 15mg/kg Dox, IP); Timokinon-5 (TQ-5, 5 mg/kg TQ, PO); TQ-20 (20 mg/kg TQ, PO); Resveratrol-5 (5 mg/kg Res, PO, günaşırı); Res-20 (20 mg/kg Res, PO); Dox+TQ-5; Dox+TQ-20; Dox+Res-5 ve Dox+Res-20 olmak üzere 10 gruba ayrıldı. 21 günlük deneme sonunda gruplardan rastgele 6 denek seçildi. Vücut ağırlığı tartıldıktan sonra, ötenazi uygulanan ratların karaciğerleri diseke edildi ve tartıldı. Karaciğer örneklerine rutin doku işleme işlemleri uygulandı. Mikroskobik olarak, hepatositlerde dejenerasyon, nekroz/apoptoz, safra kanalı hiperplazisi, disosiasyon, konjesyon, karyomegali, mononükleer hücre infiltrasyonu, çift çekirdekli hepatosit ve mitoz yönünden incelenerek her bir vaka için karaciğer total lezyon skoru hesaplandı.
Bulgular: Dox uygulaması relatif karaciğer ağırlığını arttırırken, TQ ve Res gruplarında Dox kaynaklı artış önlendi (p<0.05). Dox ile artan karaciğer total lezyon skorunun TQ ve Res gruplarında daha düşük olduğu gösterildi (p<0.05). Ancak Dox+TQ-5, Dox+TQ-20 ve Dox+Res-20 grupları nekroz/apoptozda düzelme saptanmadı.
Öneri: TQ ve Res (5 ve 20 mg/kg), Dox tarafından indüklenen total karaciğer lezyon skorunu azalttı. TQ ve Res, dejenerasyon ve inflamasyonu azaltmasına rağmen, anahtar kriterlerden biri olan nekroz/apoptoz üzerindeki zayıf koruyucu etkileri, kontrolsüz kullanımları için sınırlayıcı bir neden olarak kabul edildi.
Evaluation of bacterial translocation in cats undergoing laparotomy
Authors: Parlak Kurtulus , Altan Semih , Yesilmen Alp Simten , Akyol Eyup Tolga , Uzunlu Elgin Orcum , Zamirbekova Nuriza , Alkan Fahrettin
Published: September 2022

Amaç: Kedilerde intraabdominal basıncı arttırdığı düşünülen ya da bağırsak duvarına basınç yapan patolojilere yönelik laparotomi uygulamalarında bakteriyel translokasyonun (BT) varlığının değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntem: Selçuk Üniversitesi Hayvan Hastanesine getirilen, klinik, laboratuar, ultrasonografi ve radyografi muayene sonucu laparotomi kararı alınan 25 kedi değerlendirildi. Operasyon esnasında abdominal bölgeye girildikten hemen sonra periton sıvısından ve uygun olan bir mezenteriyel lenf nodülünden (MLN) steril swap ile sürüntü örnekleri alındı. Bakteriyel suşların tanımlanması gerçekleştirildi ve oluşan bakteriyel spektrumlar analiz edildi. Bakteriyel suşların antibiyotik direnci Kirby-Bauer disk difüzyon metodu ile belirlendi.
Bulgular: 25 kedinin 4’ünde (%16) yabancı cisim nedeniyle bağırsak perfüzyonunun bozulmasına bağlı BT saptandı. BT’nin 2’si sadece MLN’den 2’si ise hem periton boşluğu hem de MLN’den alınan swab örneklerinden izole olduğu belirlendi. Peritonda üreyen bakterilerin %50’sini E. faecalis (n=2), %50’sini ise E. faecium (n=2) oluşturduğu belirlenirken lenf yumrusundan alınan örneklerde P. fluorescens ve E. faecalis bakterilerinin ürediği belirlendi.
Öneri: İntraabdominal basıncı ya da bağırsak duvarını etkileyen patolojilerin varlığında akla BT gelmelidir. Özellikle bağırsak duvarına doğrudan etki eden (yabancı cisim, konstipasyon, obstipasyon vb.) patolojilerde BT şüphesinin daha da artması gerektiği düşünülmektedir. Antibiyogram yapılarak spesifik antibiyotik kullanımının prognoz açısından daha olumlu olacağı düşünülmektedir.
Evaluation of relationships between dogs and owners: the Turkish translation, reliability and validity study of cat/dog owner relationship scale (C/DORS)
Authors: Kaya Ufuk , Ozen Dogukan , Yazlik Murat Onur , Kosem Selim , Gurcan Ismayil Safa
Published: September 2022

Amaç: Bu çalışmanın amacı, köpekler ve sahipleri arasındaki ilişkilerin kalitesini değerlendirmek için kullanılabilecek kedi/köpek sahibi ilişki ölçeğini (C/DORS) Türkçe'ye çevirmek ve Türkiye’de farklı demografik değişkenler arasında ilişki kalitesini değerlendirmektir.
Gereç ve Yöntem: Kedi/köpek sahibi ilişki ölçeği (C/DORS) uzman bir ekip tarafından orijinal dili İngilizce'den Türkçe'ye çevrildi. Çalışmaya katılmaya gönüllü olan köpek sahiplerinden ölçek aracılığıyla bilgi toplanmıştır. Köpek sahiplerinin cinsiyeti, eğitim durumu ve maddi durumu da toplandı. Ölçeğin geçerlik ve güvenirliği Cronbach's alpha ve faktör analizi kullanılarak değerlendirildi.
Bulgular: İlk istatistiksel analizler ölçekte faktör analizinin kullanılabileceğini (Bartlett küresellik testi, p<0,001) ve örneklem büyüklüğünün yeterli olduğunu (KMO testi=0,619) ortaya koydu. Algılanan duygusal yakınlık, evcil hayvan-sahibi etkileşimi ve algılanan maliyet olarak üç alt boyuta sahip olan ölçeğin toplam açıkladığı varyans %43,90 olarak bulundu. Ölçeğe ait Cronbach alfa katsayısı 0,844 olarak tespit edildi. Ölçek alt boyut skorlarının cinsiyet (p>0,05) ve gelir durumu (p>0,05) açısından istatistiksel olarak benzer seviyelerde olduğu görüldü. Algılanan maliyet skoru eğitim durumu açısından istatistiksel olarak anlamlı bulundu (p<0,05).
Öneri: Türkçe’ye uyarlanan ve geçerlik-güvenirliği belirlenmiş olan bu ölçeğin Türkiye’de köpek-sahibi ilişkilerini ölçebilen ilk ölçek olma niteliği taşıdığı düşünülmektedir. Ayrıca, bu çalışma ölçek geliştirme ve uyarlama çalışmaları aracılığıyla Türkiye’de pet hayvanı-insan ilişkilerinin incelenmesi hususunda faydalı olacaktır.
Histopathological investigation of the effect of coenzyme q10 on intestinal mucosa and tight junction proteins in experimental colitis model
Authors: Akarca Dizakar Saadet Ozen , Demirel Murside Ayse
Published: September 2022

Amaç: Bu çalışmanın amacı Koenzim Q10’ nun sıçanlarda asetik asitle indüklenmiş deneysel kolit modelinde mukoza, goblet hücre yoğunluğu ve sıkı bağlantı proteinleri üzerine olan etkisinin araştırılmasıdır.
Gereç ve Yöntem: Çalışmada 24 adet, 10 haftalık dişi Wistar albino sıçan kullanıldı ve Kontrol grubu (n=4), Kolit grubu (n=10) ve Kolit+Koenzim Q10 grubu (n=10) olarak üç gruba ayrıldı. Deneysel kolit modeli %4’ lük asetik asit ile oluşturuldu. Kolit indüksiyonundan bir gün sonra Kolit+Koenzim Q10 grubuna 10 gün boyunca gavaj yolu ile Koenzim Q10 (30 mg/kg/gün) uygulandı. Tedavi prosedürünün sonunda deney hayvanlarının sakrifikasyonu gerçekleştirildi. Kolon dokularına ait makroskobik değerlendirme yapıldı. Kolon kesitleri Masson’un üçlü boyası ve Alsian mavisi ile boyanarak mikroskobik skorlama ve goblet hücre yoğunluğu; Okludin, Zonula Okludens-1 ve Klaudin-1 immonohistokimyasal analizleri ile de sıkı bağlantı proteinleri değerlendirildi.
Bulgular: Kolit grubuna ait kolon dokularının makroskobik ve mikroskobik skorlamaları kontrol grubuna kıyasla istatistiksel olarak anlamlı şekilde artış gösterdi (p<0.05). Kolit+Koenzim Q10 grubunda ise makroskobik ve histopatolojik hasarın anlamlı şekilde azaldığı (p<0.05), benzer şekilde Koenzim Q10 uygulaması ile Alsian mavisi pozitif alan yüzdesinin kolit grubuna göre istatistiksel olarak artış gösterdiği (p<0.05) ve buna bağlı goblet hücre yoğunluğunun arttığı, mukozal bariyerin bütünlüğünde önemli olan sıkı bağlantı proteinlerinin de immunoreaktivitelerinde artışın olduğu dikkati çekti.
Öneri: Sonuç olarak, Koenzim Q10, asetik asit ile indüklenen kolit modelinde, kolon dokusu üzerinde histopatolojik değişimler ve sıkı bağlantı proteinleri üzerinde pozitif etki göstermiştir. Ancak Koenzim Q10'un ülseratif kolitli hastalara karşı koruyucu etkileri hakkında daha detaylı ve ileri moleküler tekniklerle desteklenmiş çeşitli deneysel ve klinik araştırmaların gerekli olduğu düşünülmektedir.
YILLIK PROGRAMLARIN EMREDİCİ HÜKÜMLERİNİN HUKUKİ ANALİZİNE İLİŞKİN ÖRNEK OLAY İNCELEMESİ
Authors: ARSLANTÜRK Yalçın
Published: September 2022

Ülkemizde ekonomik ve sosyal kalkınma, genel olarak beş yıllık hazırlanan kalkınma planlarıyla belirlenen hedefler doğrultusunda gerçekleştirilmeye çalışılmaktadır. Bu planların yıllık uygulamaları ise yıllık programlarla belirlenen daha somut hedef ve tedbirlerle gerçekleştirilmektedir. Dolayısıyla yıllık programlarda karara bağlanan hususların gereği gibi gerçekleştirilmesi kalkınma için önem arz etmektedir. Ancak yıllık programlarla kararlaştırılan tüm hususlar gereği gibi gerçekleştirilmemekte ve bunlar da sorgulanmamaktadır. Bu itibarla sorgulama yapabilmeyi sağlayacak bir program kararı ve buna yönelik yapılan faaliyet, çalışmada örnek olay olarak seçilmiştir. Böylece yıllık programla kararlaştırılan faaliyetin gerçekleşme durumu tespit edilerek sonuca ilişkin hukuki sorumluluk analiz edilmiştir. Çalışmada bu faaliyetin gereği gibi yerine getirilmemesi neticesinde uğranılan kamu zararı hesaplanarak yıllık programlarla konulan hedeflerin ve belirlenen faaliyetlerin gerçekleştirilmesinin ne derece önemli olduğu ortaya konulmaya çalışılmıştır. Konuya ilişkin başvurulabilecek idari ve cezai yaptırımlar da irdelenerek program hükmünün yerine getirilmeyişinin karşılığı tartışılmıştır. Böylece kamu kaynaklarının korunması hususunda hukuki bir katkı sağlanmaya çalışılmıştır.
Measurement and calibration of discrete element simulation parameters of crushed sugarcane tail leaves
Authors: Lei Junle , Wang Shuaiwei , Lei Dingyuan , Liu Zhaochong
Published: September 2022

Discrete element simulation parameters of the tail stem and tail leaves of crushed sugarcane tail leaves (STL) were calibrated by a combination of physical experiments and simulation optimization design. First, the values or ranges of the basic physical parameters and contact parameters of crushed STL were measured using physical tests, and the results were used as the basis for the selection of the simulation parameters. Plackett-Burman testing was applied for the significance screening of the initial parameters. Then, the error values and significant parameters of stacking angle for the second-order regression models were obtained using the steepest ascent experiment and the Box-Behnken optimization test. An analysis of variance (ANOVA) was also performed. Finally, using 37.52° stacking angle of physical test as the validation target, the optimal combination of parameters was obtained: coefficient of static friction (COSF) for tail stem-tail stem of 0.45, COSF for tail leaf-tail leaf of 0.38, coefficient of rolling friction (CORF) for tail stem-tail stem of 0.14, and CORF for tail stem-tail leaf of 0.12. The error of stacking angle obtained from the simulation and the physical tests was 0.976%, which verifies the reliability of the optimal parameters.
Experimental study on flexural behavior of box floors with orthogonal rib beams made of poplar laminated veneer lumber
Authors: Su Xiangyu , Chen Jing , Liu Yan , Sun Xufeng , Meng Gong , Wang Haida
Published: September 2022

This study examined the flexural behavior of the poplar laminated veneer lumber (LVL) box floor with orthogonal rib beams. Four 3.6 m × 4.8 m box floor samples made of poplar LVL orthogonal rib beams and oriented strand board (OSB) plates were tested under vertical uniform loading, from which the bearing capacity, stiffness, and failure characteristics were analyzed. There was no damage in all box floor samples at the normal service load of 2.5 kN/m2, and the maximum deflection was far less than the allowable value. When the maximum load was applied, the load-displacement curve of each floor sample exhibited a linear relationship without obvious failure. However, localized failure was manifested as the dislocation slip of the rib beams relative to the upper and lower floor slabs at the corner nodes and the joint expansion and staggered floors at the bottom plate, with obvious failure signs. The rib beam height had the most significant impact on the floor stiffness, followed by the spacing of short-side rib beams, whereas the OSB plate thickness had lest impact. The mid-span deflections of poplar LVL orthogonal ribbed box floor samples, which were calculated using the analog slab method, were in good agreement with the experimental results with an error being less than 10%.
Do Gender and Age Matter in Employment – Sectoral Growth Relationship Over the Recession and Expansion
Authors: Butkus Mindaugas , Dargenytė-Kacilevičienė Laura , Matuzevičiūtė Kristina , Ruplienė Dovilė , Šeputienė Janina
Published: September 2022

This paper examines age- and gender-specific employment sensitivity to growth across different economic sectors. By applying a non-linear panel specification of Okun’s first-difference equation on EU-28 countries for 1995-2019, we estimate age-, gender-, and sector-specific employment intensities to growth. Our study examines the ability of growth in different sectors to generate total employment opportunities. Results show that regardless of gender or age, the employment growth is mainly driven by the services sector growth. Still, if we consider the share of a sector in the economy, the construction sector is found to be the most employment-intensive. Our estimates show that the male and female employment intensities of growth in services are quite equal. Considering the employment opportunities by gender, the main differences were found in the construction sector. Expansion and recession were confirmed to have a significantly different effect on the employment rate only in the construction sector regardless of age and gender.
Theoretical fundamentals of political-economic analysis of public governance and administration
Authors:   Odessa National Economic University, Zveryakov Mykhailo , Hrymaliuk Andrii ,   Odessa National Economic University
Published: September 2022

The legal form of public administration is analyzed, its internal economic content related to material production relations and the objective economic laws immanent in them is investigated. The research methodology is based on the demarcation of the structure and dynamics of the political-economic system, which is consistently carried out by the Odesa School of Economic Theory. It is shown that the political and economic content of public management and administration always has a concrete-historical character. The modern standard of an effective political and economic system is the "mirror symmetry" of its structural and dynamic dependencies. Such "mirror" symmetry is achieved only when the "top-down" dynamic dependence includes all structural levels of the political-economic system in sequence: public management and administration – objective production relations – productive forces of society. If one of these three levels falls out of the "chain" of dynamic dependencies, the system ceases to meet the political and economic requirements of modern development and is unable to find adequate answers to historical challenges. In the modern state-capitalist model of managed development, dynamic dependence is able to cover all three structural levels in the process of consciously using the objective economic laws of capitalism for the development of productive forces, including public management and administration. The practical significance of the research results is related to the justification of the objective necessity for Ukraine of a state-capitalist model of managed development, in which public management and administration are aimed at the conscious use of objective economic laws for the development of productive forces.
Selumetinib for Refractory Pulmonary and Gastrointestinal Bleeding in Noonan Syndrome
Authors: Chakraborty Abhishek , Beasley Gary , Martinez Hugo , Jesudas Rohith , Anton-Martin Pilar , Christakopoulos Georgios , Kramer Jennifer
Published: September 2022

A 15-year-old-boy with Noonan syndrome and status post orthoptic heart transplant developed mixed mitral valve disease and underwent mechanical mitral valve replacement 6 months before presentation with acute respiratory distress. He developed massive pulmonary hemorrhage that required veno-venous extracorporeal membrane oxygenation (ECMO) support. He had a prolonged anticoagulation free ECMO course of 4 weeks, with ongoing recurrent pulmonary hemorrhage and underwent several rounds of coil embolization of aortopulmonary collaterals. ECMO course was complicated by significant nasopharyngeal bleeding that required embolization of the sphenopalatine artery. Shortly after decannulation, he developed massive gastrointestinal and peritoneal hemorrhage that was treated by embolization of the left gastric artery and a branch of the internal iliac artery. His bleeding was attributed to neo-angiogenesis. Initial treatment with propranolol was unsuccessful. Subsequent treatment with interferon α 2b demonstrated efficacy, but severe neutropenia required cessation of therapy. Because functional alterations of the rat sarcoma virus-mitogen activated protein kinase signaling pathway and protein tyrosine phosphatase nonreceptor type (PTPN11) mutations in Noonan syndrome are known to be associated with neo-angiogenesis, we used the mitogen-activated protein kinase inhibitor selumetinib as a gene-targeted therapy with the hope of controlling bleeding and inhibiting neo-angiogenesis. After initiation of selumetinib, bleeding stopped and allowed the patient to be discharged from the hospital on dipyridamole as antiplatelet prophylaxis for his mechanical mitral valve. He had no further bleeding episodes through 1 year after hospital discharge.
Escala de grises de imágenes radiográficas en la evaluación del contenido de humedad en semillas de soja
Authors: Trujillo Heiber Andres , Gomes Junior Francisco Guilhien , Rondinel Mendoza Natalie Verónika , Trujillo Carlos Humberto
Published: September 2022

El grado de humedad es uno de los factores más importantes en la elección de procedimientos para obtención de semillas de alta calidad. En la mayoría de los programas de control de calidad, el grado de humedad se determina mediante pruebas de laboratorio con base a la remoción máxima de agua cuando la semilla se somete a la aplicación de calor en condiciones controladas. Las radiografías se caracterizan por la generación de imágenes con diferentes niveles de gris luego de la interacción de los rayos X con los tejidos de la semilla. El objetivo de esta investigación fue determinar los valores de escala de grises de imágenes radiográficas de semillas de soja (Glycine max (L.)) en diferentes niveles de hidratación, buscando establecer relaciones con el método convencional de determinación de humedad. Se analizaron imágenes radiográficas de semillas de dos lotes con diferencias en el tamaño de semillas en diferentes períodos de hidratación. Con las imágenes se determinaron los valores de la escala de grises en diferentes regiones de la semilla y se compararon con la prueba de humedad por el método convencional. Los valores de la escala de gris presentaron variación entre 120 a 187 y 134 a 215/píxeles para semillas pequeñas y semillas grandes, respectivamente. El análisis de imágenes según valores de gris obtenidos en diferentes periodos de hidratación permitió verificar las diferencias en las tonalidades de las estructuras vitales de semillas de soja de diferentes tamaños.
Inhibition and stimulation of mycelial growth of Moniliophthora roreri by flutolanil in populations of Ecuador
Authors: Amaya Márquez Darlyn José , Espinoza-Lozano Fernando , Villavicencio-Vásquez Mirian Elizabeth , Sosa del Castillo Daynet , Pérez-Martínez Simón
Published: September 2022

Frosty pod rot (FPR) of cacao is caused by Moniliophthora roreri (MR). Effective management must include chemical or biological control, in addition to agronomic tactics. Flutolanil has been effective in controlling FPR. The objective of this research was to determine the response to flutolanil of MR isolates from the Amazon and Coast regions of Ecuador. Percentage of mycelial growth inhibition (PGI), and medium inhibitory concentration (IC50) against three concentrations of the fungicide were determined. One µg mL-1 of flutolanil in the culture medium inhibited completely the growth of the 76 MR isolates. At 0.1 μg mL-1, 74/76 were inhibited between 70-97 % compared to the control. Conversely, at the lower concentrations (0.01-0.001 μg mL-1) the results of inhibition were only of 22 % and 47 %, respectively. Four groups were identified: one included the most sensitive (66/76) to different degrees, and three groups representing 10 isolates that were stimulated at low concentrations of flutolanil. IC50 values were low, indicating very high sensitivity in the MR population. IC50max were 0.1342 and 0.1457 in two isolates from the Coast and the Amazon regions, respectively. Isolates from the Coast were significantly less sensitive to flutolanil than those from the Amazon (  IC50 = 0.046 ± 0.03 and  IC50 = 0.030 ± 0.02, respectively), however, the differences were minimal. There were no significant differences when comparing the provinces. The most stimulated isolates were found in the provinces of Orellana and Los Ríos. It is concluded that flutolanil seems effective against the causal agent of FPR in Ecuador, both Coast and Amazon regions.
Protocolo de propagación vegetativa de Hedeoma teyucuarensis especie medicinal endémica en peligro de extinción
Authors: Duarte Evelyn Raquel , Schamne Daniel Ricardo , Domínguez Juan , Niella Fernando Omar , Keller Héctor Alejandro , Rocha Sandra Patricia
Published: September 2022

Resumen Hedeoma teyucuarensis es una especie microendémica del único fragmento del bioma Cerrado de la Argentina desarrollado sobre areniscas. Se encuentra en peligro crítico dado que es utilizada en medicina popular para combatir los parásitos intestinales. El objetivo del presente estudio es evaluar la factibilidad de obtener plantas madre de H. teyucuarensis a partir de estacas, empleando diferentes concentraciones de ácido 1-naftalenacético (ANA) en arena, perlita y corteza de pino. Se cosecharon estacas de plantas ubicadas en su área de distribución natural (San Ignacio, Misiones, Argentina). Posteriormente, del material vegetal cosechado, se obtuvieron estacas apicales y subapicales de un largo de 7 cm. Las bases de estas son sumergidas en una solución de ANA en las dosis 0, 100 y 250 mg.kg-1, durante 30 minutos y luego en una solución fúngica por 20 minutos. Las estacas son colocadas en macetas de 200 cm3, que contienen como sustrato, arena, perlita y corteza de pino. El mayor porcentaje de enraizamiento se obtiene en las estacas del tratamiento testigo. La concentración de ANA no afecta el porcentaje de enraizamiento, pero si en el número de raíces. Este trabajo ha demostrado que el tipo de estaca como de sustrato utilizado afecta el enraizamiento y por ende la obtención de plantas. Este estudio aporta una metodología de propagación vegetativa para obtener plantas, el cual puede servir para conservar esta especie en peligro.
Respuesta de tres cultivares de Rubus spp. en sus etapas de crecimiento vegetativo y reproductivo bajo macrotúneles
Authors: Solís-Mera Julián A.
Published: September 2022

La tecnología de macrotúneles es una alternativa que permite disminuir el impacto ocasionado por las condiciones climáticas adversas y la incidencia de plagas y enfermedades, mejorando el rendimiento y la calidad. El trabajo tiene como objetivo evaluar la respuesta de los tres cultivares de Rubus spp. en sus etapas de crecimiento vegetativo y reproductivo bajo macrotúnel, así como la incidencia y severidad de plagas y enfermedades, con el fin de encontrar las características propias de cada cultivar que permitan diferenciarlos morfológica y fenológicamente. Mediante un análisis de varianza se determinó que los cvs. San Antonio y Castilla sin espinas presentan características morfológicas similares; mientras que el cv. Brazos se caracteriza por ser un cultivar rústico el cual presenta el mayor peso de fruto (10.60 g) y rendimiento (179.03 g/planta/ciclo-4), sin embargo, es el que menor sólidos solubles presenta (5.8°Brix) en comparación con ‘Castilla’ que alcanzo el mayor valor (10.88 °Brix). En cuanto al desarrollo fenológico, el más precoz es ‘Brazos’ (155 días de trasplante a cosecha) y el más tardío es ‘Castilla’ (169 días). Por otra parte, los resultados muestran que, en promedio, la temperatura al interior de los macrotúneles aumenta de 5 a 10 °C, siendo estas condiciones inadecuadas para el desarrollo del cultivo, favoreciendo la incidencia y proliferación de enfermedades como el mildeo polvoso y plagas como los áfidos. ‘Brazos’ se caracteriza por tener una alta capacidad de resistencia a plagas (1 %) y enfermedades (11 %); mientras que ‘Castilla’ es el cultivar más susceptible con una alta incidencia (76 %) y severidad (12 %).
Optimización de la metodología de diagnóstico patológico de las humedades, desarrollado en el estudio de edificaciones de la Ciudad Universitaria en Bogotá
Authors: Chica Segovia Angélica , Ramos Zapata Maria Camila
Published: September 2022

La patología de la construcción opera con metodologías universales con tres fases claramente diferenciadas hacia el diagnóstico que conduce a una intervención. Al definir los deterioros que se presentan en la edificación y recolectar la información correspondiente, la ruta del diagnóstico, desde el trabajo de campo hasta la formulación de la intervención, depende del criterio y de los procedimientos utilizados, lo cual muchas veces no permite llevar a cabo un diagnóstico integral que efectivamente se utilice en el proceso. Esto dificulta su integración a los proyectos y los aleja de entornos estructurados y sistemáticos como el BIM (building information modeling). A partir del desarrollo y optimización de una metodología de diagnóstico elaborada en los estudios patológicos de edificios de la Universidad Nacional de Colombia, se estructuró el proceso mediante la unidad mínima, que son los mecanismos de daño, recolectando y gestionando desde el principio la información y los insumos que permitirán llevar el proceso hasta las fases de proyecto más avanzadas. El método presentado, aplicado a las humedades de la edificación, cuya complejidad es conocida, permite orientar el diagnóstico en su ejecución o su enseñanza, y así mismo afrontar la necesidad de incorporarse de manera paramétrica a un entorno BIM.
Estilos de vida en adolescentes de la Provincia Sabana Centro departamento de Cundinamarca, Colombia (2017)
Authors: Aguilera–Rojas Sandra Elizabeth , Jiménez–Peña Oscar Mauricio , Ruiz–García Luz Amparo
Published: September 2022

Objetivo: caracterizar los estilos de vida de estudiantes de grado 11 en los colegios oficiales de la Provincia Sabana Centro, Cundinamarca, a partir de creencias y prácticas en torno a la actividad física, el manejo del tiempo libre, los hábitos alimentarios, el consumo de sustancias psicoactivas y el autocuidado. Métodos: se realizó un estudio cuantitativo, descriptivo transversal en una muestra de 281 estudiantes. Resultados: la población objeto del estudio presenta hábitos y conductas no favorables, especialmente en lo concerniente a prácticas alimentarias, actividad física, manejo del sueño, uso de sustancias psicoactivas y sexualidad. Conclusión: la población escolar adolescente evidencia estilos de vida, actitudes y prácticas poco saludables, principalmente en lo relacionado a actividad física, hábitos alimentarios, manejo del sueño, uso de sustancias psicoactivas y sexualidad. Estos aspectos constituyen factores de riesgo frente al padecimiento de enfermedades crónicas no transmisibles a edades tempranas. Es necesario diseñar programas de fomento y promoción de la salud y prevención de la enfermedad que involucren procesos psicosociales