bluuebunny/crossref_metadata_2025 huggingface dataset:
Future Changes of Extreme Precipitation and Related Atmospheric Conditions in East Asia under Global Warming Projected in Large Ensemble Climate Prediction Data
Authors: He Sicheng , Takemi Tetsuya
Published: July 2024

Extreme precipitation is expected to pose a more severe threat to human society in the future. This work assessed the historical performance and future changes in extreme precipitation and related atmospheric conditions in a large ensemble climate prediction dataset, the database for Policy Decision-making for Future climate change (d4PDF), over East Asia. Compared with the Tropical Rainfall Measuring Mission (TRMM) and fifth major global reanalysis produced by ECMWF (ERA5) datasets, the historical climate in d4PDF represents favorably the precipitation characteristics and the atmospheric conditions, although some differences are notable in the moisture, vertical motion, and cloud water fields. The future climate projection indicates that both the frequency and intensity of heavy precipitation events over East Asia increase compared with those in the present climate. However, when comparing the atmospheric conditions in the historical and future climates for the same precipitation intensity range, the future climate indicates smaller relative humidity, weaker ascent, less cloud water content, and smaller temperature lapse rate, which negatively affect generating extreme precipitation events. The comparison of the precipitation intensity at the same amount of precipitable water between the historical and future climates indicates that extreme precipitation is weaker in the future because of the more stabilized troposphere in the future. The general increase in extreme precipitation under future climate is primarily due to the enhanced increase in precipitable water in the higher temperature ranges, which counteracts the negative conditions of the stabilized troposphere.

Significance Statement

Extreme precipitation can have disastrous effects on human lives, economy, and ecosystems and is anticipated to significantly increase in both intensity and frequency under future climate. The purpose of this study is to investigate the mechanism for the future change of extreme precipitation. We examined the relationship between future changes in extreme precipitation and changes in the related atmospheric conditions. It is important for reducing uncertainties in future projections of extreme precipitation. Our results highlight that the future atmospheric condition is unfavorable for generating future extreme precipitation events in terms of stability and humidity changes. The increase in the column moisture content is the primary factor for the increase of extreme precipitation, which counteracts the negative conditions.
Examining Outer Band Supercell Environments in Landfalling Tropical Cyclones Using Ground-Based Radar Analyses
Authors: Alford A. Addison , Schenkel Benjamin , Hernandez Samuel , Zhang Jun A. , Biggerstaff Michael I. , Blumenauer Emily , Sandmæl Thea N. , Waugh Sean M.
Published: July 2024

Supercells in landfalling tropical cyclones (TCs) often produce tornadoes within 50 km of the coastline. The prevalence of TC tornadoes near the coast is not explained by the synoptic environments of the TC, suggesting a mesoscale influence is likely. Past case studies point to thermodynamic contrasts between ocean and land or convergence along the coast as a possible mechanism for enhancing supercell mesocyclones and storm intensity. This study augments past work by examining the changes in the hurricane boundary layer over land in the context of vertical wind shear. Using ground-based single- and dual-Doppler radar analyses, we show that the reduction in the boundary layer wind results in an increase in vertical wind shear/storm-relative helicity inland of the coast. We also show that convergence along the coast may be impactful to supercells as they cross the coastal boundary. Finally, we briefly document the changes in mesocyclone vertical vorticity to assess how the environmental changes may impact individual supercells.
Comparing autologous blood, corticosteroid, and a combined injection of both for treating lateral epicondylitis: a randomized clinical trial
Authors: Cakar Albert , Gozlu Ozgur Dogus
Published: July 2024

Background

Because lateral epicondylitis is a common musculoskeletal disorder that affects the forearm's extensor tendons, an effective therapeutic approach should reverse the degeneration and promote regeneration. This study aimed to compare the efficacies of autologous blood (AB) injection, corticosteroid (CS) injection, and a combined injection of both in treating lateral epicondylitis (LE), hypothesizing that the combined approach might offer immediate symptom resolution and a lower recurrence.

Materials and methods

A total of 120 patients diagnosed with lateral epicondylitis were systematically distributed among three distinct therapeutic injection groups. Those in the AB group were administered 1 ml of autologous venous blood mixed with 2 ml of 2% prilocaine HCl. Participants in the CS category were given 1 ml of 40 mg methylprednisolone acetate mixed with 2 ml of 2% prilocaine HCl. Meanwhile, patients in the combined group received a mixture containing 1 ml each of autologous venous blood and 40 mg methylprednisolone acetate along with 1 ml of 2% prilocaine HCl. Prior to receiving their respective injections, a comprehensive assessment of all participants was carried out. Follow-up assessments were subsequently conducted on days 15, 30, and 90 utilizing metrics of the patient-rated tennis elbow evaluation (PRTEE) and measurements of hand grip strength (HGS).

Results

One patient dropped out from the combined group, and 119 patients completed the trial. No complications were recorded during the course of follow-up. By day 15, all groups had demonstrated significant PRTEE improvement, with CS showing the most pronounced reduction (p = 0.001). However, the benefits of CS had deteriorated by day 30 and had deteriorated further by day 90. The AB and AB + CS groups demonstrated sustained improvement, with AB + CS revealing the most effective treatment, achieving a clinically significant improvement in 97.4% of the patients. The improved HGS parallelled the functional enhancements, as it was more substantial in the AB and AB + CS groups (p = 0.001), corroborating the sustained benefits of these treatments.

Conclusions

The study concluded that while AB and CS individually offer distinct benefits, a combined AB + CS approach optimizes therapeutic outcomes, providing swift and sustained functional improvement with a lower recurrence rate. These findings have substantial clinical implications, suggesting a balanced, multimodal treatment strategy for enhanced patient recovery in LE.

Level of evidence: Randomized clinical trial, level 1 evidence.

Trial registration: NCT06236178.
The association between systemic inflammation markers and paroxysmal atrial fibrillation
Authors: Zhao Xuechen , Huang Lei , Hu Jianan , Jin Nake , Hong Jun , Chen Xudong
Published: July 2024

Background

Systemic inflammation markers have recently been identified as being associated with cardiac disorders. However, limited research has been conducted to estimate the pre-diagnostic associations between these markers and paroxysmal atrial fibrillation (PAF). Our aim is to identify potential biomarkers for early detection of PAF.

Methods

91 participants in the PAF group and 97 participants in the non-PAF group were included in this study. We investigated the correlations between three systemic inflammation markers, namely the systemic immune inflammation index (SII), system inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI), and PAF.

Results

The proportion of patients with PAF gradually increased with increasing logSII, logSIRI, and logAISI tertiles. Compared to those in the lowest tertiles, the PAF risks in the highest logSII and logSIRI tertiles were 3.2-fold and 2.9-fold, respectively. Conversely, there was no significant correlation observed between logAISI and PAF risk within the highest tertile of logAISI. The restricted cubic splines (RCS) analysis revealed a non-linear relationship between the elevation of systemic inflammation markers and PAF risk. Specifically, the incidence of PAF is respectively increased by 56%, 95%, and 150% for each standard deviation increase in these variables. The ROC curve analysis of logSII, logSIRI and logAISI showed that they had AUC of 0.6, 0.7 and 0.6, respectively. It also demonstrated favorable sensitivity and specificity of these systemic inflammation markers in detecting the presence of PAF.

Conclusions

In conclusion, our study reveals significant positive correlations between SII, SIRI, and AISI with the incidence of PAF.
Mid-upper arm circumference predicts the risk of gestational diabetes in early pregnancy
Authors: Ma Ning , Bai Liwei , Niu Ziru , Lu Qiang
Published: July 2024

Background

The present work aimed to assess the value of mid-upper arm circumference (MUAC) at 8 to 12 weeks in predicting the occurrence of gestational diabetes mellitus (GDM).

Methods

According to eligibility criteria, 328 women with singleton pregnancies who underwent routine antenatal check-ups at Qinhuangdao Maternal and Child Health Hospital from September 2017 to September 2020 were included. The patients were divided into the gestational diabetes mellitus (GDM) and non-GDM groups according to oral glucose tolerance test (OGTT) data from gestation weeks 24 to 28. Clinical data were compared between the two groups. Logistic regression analysis was performed to determine factors independently predicting GDM. Receiver operating characteristic (ROC) curve analysis was employed to analyze the value of MUAC in predicting the occurrence of GDM. The optimal cut-off points were calculated.

Results

In logistic regression analysis, pre-pregnancy weight, waist circumference, MUAC, UA, TG, and HDL-C independently predicted the occurrence of GDM (P < 0.05). MUAC retained statistical significance upon adjustment for various confounders (OR = 8.851, 95%CI: 3.907–20.048; P < 0.001). ROC curve analysis revealed good diagnostic potential for MUAC in GDM (AUC = 0.742, 95%CI: 0.684–0.800, P < 0.001), with a cut-off of 28.5 cm, sensitivity and specificity were 61% and 77%, respectively.

Conclusion

Pregnant women with MUAC >28.5 cm are prone to develop GDM during pregnancy, indicating that MUAC as an important predictive factor of GDM in early pregnancy.
Applying the multiphase optimization strategy to evaluate the feasibility and effectiveness of an online road safety education intervention for children and parents: a pilot study
Authors: Pham Julia , Buttazzoni Adrian , Gilliland Jason
Published: July 2024

Background

Reports of children’s engagement in active transportation outline low participation rates in many countries despite many associated mental, physical, and social health benefits. One of the main contributors to this phenomenon is a cited lack of education and knowledge among children regarding active travel (AT), specifically road safety. To address this issue, the aim of this study was to evaluate the feasibility and effectiveness of an online road safety education intervention to promote AT among children and their parents.

Methods

Applying the Multiphase Optimization Strategy (MOST) for intervention development, implementation, and evaluation, we designed and assessed a four-module online road safety education intervention with a sample of 57 parent-child dyads using a 23 factorial design featuring both qualitative and quantitative analyses.

Results

Main intervention feasibility findings include positive and critical feedback on the program’s content and design, and moderate participant engagement as reflected by program retention and completion rates. With respect to the preliminary intervention effectiveness on children, a significant improvement in road safety knowledge scores was observed for groups that feature the “wheeling safety and skills” module. Slight improvements in AT knowledge scores across all the intervention groups were observed, but were not of significance. Preliminary intervention effectiveness on select parental AT practices and perceptions saw significant improvements in some groups. Groups that featured the ‘wheeling safety and skills’ module exhibited significantly higher guided choice scores upon completion of the program than those who did not receive this component.

Conclusion

The MOST framework allowed us to design and evaluate the feasibility and preliminary effectiveness of an online road safety education intervention. The developed intervention has demonstrated that it has the potential to improve children’s road safety knowledge and some areas of parental AT practices and perceptions, to which improvements may be attributed to the inclusion of the “wheeling safety and skills” module, suggesting that the targeted focus on cycling skills is a prioritized area. AT programming and practice implications are discussed. Future research is encouraged to refine modules to better reflect the priorities of children and parents and to test these refined components among larger samples.

Word count

9,391 (excludes abstract, tables, figures, abbreviations, and references).
Diagnostic and therapeutic delays in lung cancer during the COVID-19 pandemic: a single center experience at a German Cancer center
Authors: Tarawneh Thomas S. , Mack Elisabeth K. M. , Faoro Charis , Neubauer Andreas , Middeke Martin , Kirschbaum Andreas , Holland Angélique
Published: July 2024

Background

The COVID-19 pandemic has had negative drawbacks on the healthcare system worldwide and on individuals other than those directly affected by the virus. Delays in cancer therapy and diagnosis have been reported in the literature. We hypothesized similar effects on patients with lung cancer at our center.

Methods

We retrospectively analyzed data of patients referred to our center with newly diagnosed lung cancer from 2018 to 2022. We considered distribution of UICC Stages and time from case presentation in our multidisciplinary tumor board or from therapeutic indication from treating physician to therapy initiation (surgery, systemic therapies and radiation) to define delays in diagnosis and treatment.

Results

1020 patients with newly diagnosed lung cancer were referred to our center from 2018 to 2022, with a median of 206 cases yearly (range: 200–208). Cases with Stage IV in 2020–2022 were significantly higher than in 2018–2019 (57% vs. 46%, p = 0,001). 228 operative resections took place between 2018 and 2022, 100 from January 2018 to February 2020 and 128 from March 2020 to December 2022. Median time from presentation in our tumor board to resection was also significantly longer after the beginning of the pandemic than before (22 days vs. 15,5 days, p = 0,013). No significant delays were observed for administration of systemic treatment and initiation of radiation.

Conclusions

During the pandemic higher disease stages were reported for patients with lung cancer, yet there were no clinically relevant delays in treatment. In the context of the post-covid era new diagnostic strategies are necessary to facilitate early diagnosis of lung cancer. Despite the pandemic, for patients with suspicious symptoms prompt access to healthcare facilities is essential for early diagnosis.
Clinical students’ perception of educational environment in a Nigerian university: a mixed method study
Authors: Akinpelu Aderonke O. , Oyewole Olufemi O. , Odunaiya Nse , Odole Adesola C. , Olley Jesupelumi P.
Published: July 2024

Background

Learning environment (LE) research has been given priority in higher education institutions globally because of its influence on learning processes and outcomes. Although studies reporting the perceptions of health science students about LE in Nigeria are available, none have compared the perceptions of students from different health professions. Therefore, this study aimed to assess final-year clinical students’ perceptions of their LE from four programs (dentistry, medicine, nursing, and physiotherapy) and compared their LE perceptions.

Methods

This study adopted a cross-sectional study design using a mixed method approach. The quantitative survey involved all the final-year clinical students at the University of Ibadan, and they completed the Dundee Ready Education Environment Measure (DREEM) questionnaire. The qualitative aspect involved 24 consenting students in four focus group discussions.

Results

A total of 214 out of 223 copies of the DREEM questionnaire were duly completed and returned, yielding 96.0% response rate. The participants’ mean age was 24 ± 2.3 years (ranged between 22 and 25 years, p = 0.001). The mean DREEM scores of the students from the four programs ranged between 119.68 ± 18.02 and 147.65 ± 15.89 out of a maximum of 200, interpreted as more positive than negative perceptions of LE. Physiotherapy students’ DREEM score was significantly higher than those of medical, dental, and nursing students (p < 0.001). The DREEM scores of other students did not differ significantly (p > 0.05). Dental and medical students had similar positive perceptions. The qualitative aspect revealed that the students had positive perceptions of their teachers’ knowledge base and self-acquisition of knowledge but negative perceptions of their teachers’ communication skills, infrastructural facilities, lecturer-student relationships, and hostel accommodations.

Conclusion

Although the survey indicated that these clinical students had more positive than negative perceptions of their learning environment, the qualitative aspect of the study revealed many challenges that the students were confronted with. The clinical students’ perception of their learning environment could be improved if the university authorities would address these challenges.
First real-time imaging of bronchoscopic lung volume reduction by electrical impedance tomography
Authors: Torsani Vinicius , Cardoso Paulo Francisco Guerreiro , Borges João Batista , Gomes Susimeire , Moriya Henrique Takachi , Cruz Andrea Fonseca da , Santiago Roberta Ribeiro de Santis , Nagao Cristopher Kengo , Fitipaldi Mariana Fernandes , Beraldo Marcelo do Amaral , Junior Marcus Henrique Victor , Mlček Mikuláš , Pego-Fernandes Paulo Manuel , Amato Marcelo Britto Passos
Published: July 2024

Background

Bronchoscopic lung volume reduction (BLVR) with one-way endobronchial valves (EBV) has better outcomes when the target lobe has poor collateral ventilation, resulting in complete lobe atelectasis. High-inspired oxygen fraction (FIO2) promotes atelectasis through faster gas absorption after airway occlusion, but its application during BLVR with EBV has been poorly understood. We aimed to investigate the real-time effects of FIO2 on regional lung volumes and regional ventilation/perfusion by electrical impedance tomography (EIT) during BLVR with EBV.

Methods

Six piglets were submitted to left lower lobe occlusion by a balloon-catheter and EBV valves with FIO2 0.5 and 1.0. Regional end-expiratory lung impedances (EELI) and regional ventilation/perfusion were monitored. Local pocket pressure measurements were obtained (balloon occlusion method). One animal underwent simultaneous acquisitions of computed tomography (CT) and EIT. Regions-of-interest (ROIs) were right and left hemithoraces.

Results

Following balloon occlusion, a steep decrease in left ROI-EELI with FIO2 1.0 occurred, 3-fold greater than with 0.5 (p < 0.001). Higher FIO2 also enhanced the final volume reduction (ROI-EELI) achieved by each valve (p < 0.01). CT analysis confirmed the denser atelectasis and greater volume reduction achieved by higher FIO2 (1.0) during balloon occlusion or during valve placement. CT and pocket pressure data agreed well with EIT findings, indicating greater strain redistribution with higher FIO2.

Conclusions

EIT demonstrated in real-time a faster and more complete volume reduction in the occluded lung regions under high FIO2 (1.0), as compared to 0.5. Immediate changes in the ventilation and perfusion of ipsilateral non-target lung regions were also detected, providing better estimates of the full impact of each valve in place.

Trial registration

Not applicable.
Protein glycation products associate with progression of kidney disease and incident cardiovascular events in individuals with type 1 diabetes
Authors: Adeshara Krishna , Gordin Daniel , Antikainen Anni A. , Harjutsalo Valma , Sandholm Niina , Lehto Markku J. , Groop Per-Henrik ,   on behalf of the FinnDiane Study Group
Published: July 2024

Background

Despite improved glycemic treatment, the impact of glycation on pathological consequences may persist and contribute to adverse clinical outcomes in diabetes. In the present study we investigated the association between serum protein glycation products and progression of kidney disease as well as incident major adverse cardiovascular events (MACE) in type 1 diabetes.

Methods

Fructosamine, advanced glycation end products (AGEs), and methylglyoxal-modified hydro-imidazolone (MG-H1) were measured from baseline serum samples in the FinnDiane study (n = 575). Kidney disease progression was defined as steep eGFR decline (> 3 mL/min/1.73 m2/year) or progression of albuminuria (from lower to higher stage of albuminuria). MACE was defined as acute myocardial infarction, coronary revascularization, cerebrovascular event (stroke), and cardiovascular death.

Results

Fructosamine was independently associated with steep eGFR decline (OR 2.15 [95% CI 1.16–4.01], p = 0.016) in the fully adjusted model (age, sex, baseline eGFR). AGEs were associated with steep eGFR decline (OR 1.58 per 1 unit of SD [95% CI 1.07–2.32], p = 0.02), progression to end-stage kidney disease (ESKD) (HR 2.09 per 1 unit of SD [95% CI 1.43–3.05], p < 0.001), and pooled progression (to any stage of albuminuria) (HR 2.72 per 1 unit of SD [95% CI 2.04–3.62], p < 0.001). AGEs (HR 1.57 per 1 unit of SD [95% CI 1.23–2.00], p < 0.001) and MG-H1 (HR 4.99 [95% CI 0.98–25.55], p = 0.054) were associated with incident MACE. MG-H1 was also associated with pooled progression (HR 4.19 [95% CI 1.11–15.89], p = 0.035). Most AGEs and MG-H1 associations were no more significant after adjusting for baseline eGFR.

Conclusions

Overall, these findings suggest that protein glycation products are an important risk factor for target organ damage in type 1 diabetes. The data provide further support to investigate a potential causal role of serum protein glycation in the progression of diabetes complications.
Potent synergy and sustained bactericidal activity of polymyxins combined with Gram-positive only class of antibiotics versus four Gram-negative bacteria
Authors: Wang Yan , Feng Jianwen , Yu Jiameng , Wen Lirong , Chen Lidan , An Huijie , Xiao Weibin , Zhang Bing , Feng Huanhuan , Zhou Mou , Jiang Zhihui
Published: July 2024

Background

Gram-negative bacteria (GNB) are becoming increasingly resistant to a wide variety of antibiotics. There are currently limited treatments for GNB, and the combination of antibiotics with complementary mechanisms has been reported to be a feasible strategy for treating GNB infection. The inability to cross the GNB outer membrane (OM) is an important reason that a broad spectrum of Gram-positive only class of antibiotics (GPOAs) is lacking. Polymyxins may help GPOAs to permeate by disrupting OM of GNB.

Objective

To identify what kind of GPOAs can be aided to broaden their anti-GNB spectrum by polymyxins, we systematically investigated the synergy of eight GPOAs in combination with colistin (COL) and polymyxin B (PMB) against GNB in vitro.

Methods

The synergistic effect of COL or PMB and GPOAs combinations against GNB reference strains and clinical isolates were determined by checkerboard tests. The killing kinetics of the combinations were assessed using time-kill assays.

Results

In the checkerboard tests, polymyxins-GPOAs combinations exert synergistic effects characterized by species and strain specificity. The synergistic interactions on P. aeruginosa strains are significantly lower than those on strains of A. baumannii, K. pneumoniae and E. coli. Among all the combinations, COL has shown the best synergistic effect in combination with dalbavancin (DAL) or oritavancin (ORI) versus almost all of the strains tested, with FICIs from 0.16 to 0.50 and 0.13 to < 0.28, respectively. In addition, the time-kill assays demonstrated that COL/DAL and COL/ORI had sustained bactericidal activity.

Conclusions

Our results indicated that polymyxins could help GPOAs to permeate the OM of specific GNB, thus showed synergistic effects and bactericidal effects in the in vitro assays. In vivo combination studies should be further conducted to validate the results of this study.
The role of nurses in implementation of public policy on adolescent health in Colombia, Ecuador, and Peru
Authors: De Bortoli Cassiani Silvia Helena , Moreno Dias Bruna , Rivera Jairo , Deubel Andre Noel Roth , Pérez Taycia Ramírez , Malpica Dinora Rebolledo , Caffe Sonja
Published: July 2024

Background

In Latin America, interventions aimed at adolescents’ health suffer from a shortfall of investment and lack of sustainability. Nurses, as an integral part of health services and systems, can lead the implementation and development of public health policies to improve adolescent health.

Objective

To identify and analyze the role of nurses in the development and implementation of public policies and in the provision of health care to adolescents in Colombia, Ecuador, and Peru.

Methods

The research was carried out in three phases: a documentary analysis, an online survey, and semi-structured focus groups. A total of 48 documents were analyzed, 288 nurses participated in the survey, and 29 nurses participated in the focus groups.

Results

State policies aim to guarantee rights, with special protection for children and adolescents. It is an incremental process, with greater involvement of civil society and governments. Participants reported a lack of synergy between law and practice, as well as differences in regulatory compliance in rural areas and in populations of different ethnicities and cultures. Their perception was that the protection of adolescents is not specifically enshrined in the legal bases and regulatory structures of the countries, meaning that there are both protective factors and tensions in the regulatory framework. While nurses are highly committed to different actions aimed at adolescents, their participation in policy development and implementation is low, with barriers related to a lack of specialized training and working conditions.

Conclusions

Given nurses’ involvement in different actions aimed at adolescents, they could play a fundamental role in the development of policies for adolescents and ensure their effective implementation. Policymakers should consider revising the budget to make compliance viable, incorporating and using monitoring indicators, and increasing the involvement of educational institutions and the community.
Engaging primary care professionals in OECD’s international PaRIS survey: a documentary analysis
Authors: Kendir Candan , van den Berg Michael , Bloemeke-Cammin Janika , Groene Oliver , Guanais Frederico , Rochfort Andree , Valderas Jose M. , Klazinga Niek
Published: July 2024

Healthcare professionals have first-hand experience with patients in clinical practice and the dynamics in the healthcare system, which can be of great value in the design, implementation, data analysis and dissemination of research study results. Primary care professionals are particularly important as they provide first contact, accessible, coordinated, comprehensive and continuous people-focused care. However, in-depth examination of the engagement of health professionals in health system research and planning activities—how professionals are engaged and how this varies across national contexts- is limited, particularly in international initiatives. There is a need to identify gaps in the planning of engagement activities to inform the design and successful implementation of future international efforts to improve the responsiveness of health systems to the changing needs of patients and professionals. The aim of this study was to explore how primary care professionals were engaged in the design and implementation plans of an international health policy study led by the Organisation for Economic Co-operation and Development (OECD). The OECD’s international PaRIS survey measures and disseminates information on patient-reported outcome and experience measures (PROMs and PREMs) of people living with chronic conditions who are managed in primary care. A documentary analysis of 17 written national implementation plans (country roadmaps) was conducted between January and June 2023. Two reviewers independently performed the screening and data abstraction and resolved disagreements by discussion. We reported the intended target primary care professionals, phase of the study, channel of engagement, level of engagement, and purpose of engagement. All 17 countries aimed to engage primary care professionals in the execution plans for the international PaRIS survey. While organisations of primary care professionals, particularly of family doctors, were the most commonly targeted group, variation was found in the timing of engagement activities during the different phases of the study and in the level of engagement, ranging from co-development (half of the countries co-developed the survey together with primary care professionals) to one-off consultations with whom. International guidance facilitated the participation of primary care professionals. Continuous collaborative efforts at the international and national levels can foster a culture of engagement with primary care organisations and individual professionals and enhance meaningful engagement of primary care professionals.
The biological characteristics and infection dynamics of a novel H3N2 canine influenza virus genotype in beagles
Authors: Ge Fei-fei , Shen Hai-xiao , Yang De-quan , Yang Xian-chao , Li Xin , Wang Jian , Huang Shixin
Published: July 2024

Background

The canine influenza virus (CIV) outbreak has garnered considerable attention as it poses a significant threat to dog health. During the H3N2 CIV evolution in beagles, the virus formed a new clade after 2019 and gradually became more adaptable to other mammals. Therefore, successfully elucidating the biological characteristics and constructing a canine influenza infection model is required for CIV characterization.

Methods

We performed genetic analyses to examine the biological characteristics and infection dynamics of CIV.

Results

The genotype of our H3N2 CIV strain (from 2019 in Shanghai) belonged to the 5.1 clade, which is now prevalent in China. Using MDCK cells, we investigated viral cytopathic effects. Virus size and morphology were observed using transmission electron microscopy. Beagles were also infected with 104, 105, and 106 50% egg-infectious doses (EID50). When compared with the other groups, the 106 EID50 group showed the most obvious clinical symptoms, the highest virus titers, and typical lung pathological changes. Our results suggested that the other two treatments caused mild clinical manifestations and pathological changes. Subsequently, CIV distribution in the 106 EID50 group was detected by hematoxylin and eosin (H&E) and immunofluorescence (IF) staining, which indicated that CIV primarily infected the lungs.

Conclusions

The framework established in this study will guide further CIV prevention strategies.
Quality of life in patients with acromegaly: a scoping review
Authors: Wang Wei , Yang Ting , Huang Qinghua
Published: July 2024

Purpose

To evaluate the available evidence regarding the quality of life (QoL) in patients with acromegaly, by synthesizing the psychosocial factors of QoL, QoL measures, and complementary interventions targeting QoL.

Methods

A scoping review was conducted using the PRISMA-ScR guideline. We searched six English databases (PubMed, Embase, CINAHL, Scopus, Web of Science, and the Cochrane Library) from the inception to August 21, 2023. We included observational studies involving psychosocial factors and complementary interventions targeting QoL (concept) in patients with acromegaly (population) in any setting (context). The design characteristics, psychosocial factors, measures, details of interventions, and outcomes of included studies were described in detail.

Results

Twenty-one studies were identified, including sixteen cross-sectional studies and five interventional studies. Ten categories of psychosocial factors that are associated with QoL in acromegaly. Depression and anxiety were the most frequent psychosocial factors. Seven different validated QoL measures were used. AcroQoL was the most common measure. Two categories of complementary interventions targeting QoL were identified including psychological and exercise interventions.

Conclusions

Our scoping review provides a reasonably clear picture of the current research status of QoL in acromegaly. However, this review also highlights the need to deepen understanding of QoL and psychosocial factors in the future, as well as conduct longitudinal research and qualitative research to clarify the changing trends of psychosocial factors and specific experiences of patients. Further, more potential clinical complementary interventions are needed to improve QoL for patients with acromegaly.
Investigation, management and control of a maedi outbreak in Norway in 2019-2020
Authors: Rømo Grim , Åkerstedt Johan , Nordstoga Anne Bang , Borge Anniken Jerre , Wisløff Helene , Gjerset Britt , Klevar Siv , Valheim Mette , Mjømen Irene Skei , Schei-Berg Elisabeth , Vatn Synnøve , Kampen Annette Hegermann
Published: July 2024

Background

Visna-maedi is a notifiable disease in Norway, and eliminating the disease is a national goal. The import of sheep into Norway is very limited, and strict regulations apply to the movement of small ruminants between flocks and within defined geographical regions. Several outbreaks have occurred in the last 50 years, and the most recent before 2019 occurred in Trøndelag county in Central Norway in 2002. A national surveillance programme for small ruminant lentivirus infection exists since 2003.

Results

In 2019, the national surveillance programme detected seropositive animals for small ruminant lentivirus in a sheep flock in Trøndelag. Based on the result of polymerase chain reaction analysis and histopathological findings, the Norwegian Food Safety Authority concluded the diagnosis of maedi. Further investigations detected maedi in eight additional sheep flocks in the same county. The flocks were placed under restrictions, and the authorities also imposed restrictions on 82 contact flocks. Sequencing of partial gag genes indicated that the virus in the current outbreak was related to the small ruminant lentivirus detected in the same area between 2002 and 2005.

Conclusions

The outbreak investigation shows the need for sensitive and specific diagnostic methods, and an improved and more targeted surveillance strategy. It also demonstrates the risk of disease spreading between flocks through animal movements, and highlights the importance of biosecurity and structured livestock trade. In addition to allowing livestock trade only from flocks documented free from maedi, it may be necessary to monitor sheep flocks over many years, when aiming to eliminate maedi from the Norwegian sheep population.
Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials
Authors: Ziaei Somayeh , Hasani Motahareh , Malekahmadi Mahsa , Daneshzad Elnaz , Kadkhodazadeh Katayoun , Heshmati Javad
Published: July 2024

Background

To investigate whether melatonin supplementation can enhance cardiometabolic risk factors, reduce oxidative stress, and improve hormonal and pregnancy-related factors in patients with PCOS.

Methods

We conducted a systematic search of PubMed/Medline, Scopus, and the Cochrane Library for articles published in English from inception to March 2023. We included randomized controlled trials (RCTs) on the use of melatonin for patients with polycystic ovary syndrome (PCOS). We performed a meta-analysis using a random-effects model and calculated the standardized mean differences (SMDs) and 95% confidence intervals (CIs).

Results

Six studies met the inclusion criteria. The result of meta-analysis indicated that melatonin intake significantly increase TAC levels (SMD: 0.87, 95% CI: 0.46, 1.28, I2 = 00.00%) and has no effect on FBS, insulin, HOMA-IR, TC, TG, HDL, LDL, MDA, hs-CRP, mFG, SHBG, total testosterone, and pregnancy rate in patients with PCOS compare to controls. The included trials did not report any adverse events.

Conclusion

Melatonin is a potential antioxidant that may prevent damage from oxidative stress in patients with PCOS. However, the clear effect of melatonin supplementation on cardiometabolic risk factors, hormonal outcomes, and pregnancy-related outcomes needs to be evaluated further in large populations and long-term RCTs.
VirRep: a hybrid language representation learning framework for identifying viruses from human gut metagenomes
Authors: Dong Yanqi , Chen Wei-Hua , Zhao Xing-Ming
Published: July 2024

Identifying viruses from metagenomes is a common step to explore the virus composition in the human gut. Here, we introduce VirRep, a hybrid language representation learning framework, for identifying viruses from human gut metagenomes. VirRep combines a context-aware encoder and an evolution-aware encoder to improve sequence representation by incorporating k-mer patterns and sequence homologies. Benchmarking on both simulated and real datasets with varying viral proportions demonstrates that VirRep outperforms state-of-the-art methods. When applied to fecal metagenomes from a colorectal cancer cohort, VirRep identifies 39 high-quality viral species associated with the disease, many of which cannot be detected by existing methods.
Caregiver recruitment strategies for interventions designed to optimize transitions from hospital to home: lessons from a randomized trial
Authors: Gustavson Allison M. , Horstman Molly J. , Cogswell Jodie A. , Holland Diane E. , Vanderboom Catherine E. , Mandrekar Jay , Harmsen William S. , Kaufman Brystana G. , Ingram Cory , Griffin Joan M.
Published: July 2024

Challenges to recruitment of family caregivers exist and are amplified when consent must occur in the context of chaotic healthcare circumstances, such as the transition from hospital to home. The onset of the COVID-19 pandemic during our randomized controlled trial provided an opportunity for a natural experiment exploring and examining different consent processes for caregiver recruitment. The purpose of this publication is to describe different recruitment processes (in-person versus virtual) and compare diversity in recruitment rates in the context of a care recipient’s hospitalization. We found rates of family caregiver recruitment for in-person versus virtual were 28% and 23%, respectively (p = 0.01). Differences existed across groups with family caregivers recruited virtually being more likely to be younger, white, have greater than high school education, and not be a spouse or significant other to the care recipient, such as a child. Future work is still needed to identify the modality and timing of family caregiver recruitment to maximize rates and enhance the representativeness of the population for equitable impact.
Respective contribution of baseline clinical data, tumour metabolism and tumour blood-flow in predicting pCR after neoadjuvant chemotherapy in HER2 and Triple Negative breast cancer
Authors: Payan Neree , Presles Benoit , Coutant Charles , Desmoulins Isabelle , Ladoire Sylvain , Beltjens Françoise , Brunotte François , Vrigneaud Jean-Marc , Cochet Alexandre
Published: July 2024

Background:

The aim of this study is to investigate the added value of combining tumour blood flow (BF) and metabolism parameters, including texture features, with clinical parameters to predict, at baseline, the pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in patients with newly diagnosed breast cancer (BC).

Methods:

One hundred and twenty-eight BC patients underwent a 18F-FDG PET/CT before any treatment. Tumour BF and metabolism parameters were extracted from first-pass dynamic and delayed PET images, respectively. Standard and texture features were extracted from BF and metabolic images. Prediction of pCR was performed using logistic regression, random forest and support vector classification algorithms. Models were built using clinical (C), clinical and metabolic (C+M) and clinical, metabolic and tumour BF (C+M+BF) information combined. Algorithms were trained on 80% of the dataset and tested on the remaining 20%. Univariate and multivariate features selections were carried out on the training dataset. A total of 50 shuffle splits were performed. The analysis was carried out on the whole dataset (HER2 and Triple Negative (TN)), and separately in HER2 (N=76) and TN (N=52) tumours.

Results:

In the whole dataset, the highest classification performances were observed for C+M models, significantly (p-value<0.01) higher than C models and better than C+M+BF models (mean balanced accuracy of 0.66, 0.61, and 0.64 respectively). For HER2 tumours, equal performances were noted for C and C+M models, with performances higher than C+M+BF models (mean balanced accuracy of 0.64, and 0.61 respectively). Regarding TN tumours, the best classification results were reported for C+M models, with better performances than C and C+M+BF models but not significantly (mean balanced accuracy of 0.65, 0.63, and 0.62 respectively).

Conclusion:

Baseline clinical data combined with global and texture tumour metabolism parameters assessed by 18F-FDG PET/CT provide a better prediction of pCR after NAC in patients with BC compared to clinical parameters alone for TN, and HER2 and TN tumours together. In contrast, adding BF parameters to the models did not improve prediction, regardless of the tumour subgroup analysed.
Errorless robust JPEG steganography using steganographic polar codes
Authors: Zhang Jimin , He Xiaolei , Cao Yun
Published: July 2024

Recently, a robust steganographic algorithm that achieves errorless robustness against JPEG recompression has been proposed. The method employs a lattice embedding scheme and utilizes the syndrome-trellis code (STC) for practical embedding. However, we have noticed that errorless robust embedding with STC may encounter failures due to modifications on wet coefficients, especially when a high quality factor is used by the compression channel. To solve this problem, we have discovered that using steganographic polar code (SPC) for embedding has better performance in avoiding modifications on wet coefficients. In this paper, we conduct theoretical analysis to prove the better performance of SPC in wet paper embedding. We establish the condition of avoiding modifications on wet coefficients, followed by presenting a recursive calculation method for determining the distribution of columns in the generator matrix of SPC. The findings reveal that SPC can avoid modifications on wet coefficients under a larger number of wet coefficients compared with STC, and therefore we propose a better errorless robust embedding method employing SPC. The experimental results demonstrate that under close security performance, the proposed method achieves a higher success rate compared with embedding with STC. Specifically, when the quality factor of the compressor is 95 and the payload size is 0.4 bpnzac, our method achieves a success rate of 99.85%, surpassing the 91.95% success rate of the embedding with STC.
Identifying, restoring, and remastering of the Sarinah relief sculpture in Jakarta of Indonesia: the limitations of time, space, and technology
Authors: Ardhiati Yuke , Hasan Asikin
Published: July 2024

The Sarinah historic building transformation project in Jakarta, Indonesia (2020–2022) is an adaptive reuse of the original building formed through a scientific conservation process. Therefore, this research identified, restored, and remastered the Sarinah relief sculpture of alto-relievo (high relief) and mezzo-relievo (medium relief). The invasive demolition method was used to form an atrium space to show the reappearance of the artwork by dismantling two layers of building floors above where the relief was found. The non-invasive method was implemented (a) by identifying damaged mapping artifacts, (b) by restoring, cleaning, and repairing the broken artifacts, and (c) by remastering the 3D model. All activities were supported by digital applications such as the Cartesian diagram coordinates, AutoCAD, Adobe Photoshop, Zbrush software, and close-range photogrammetry. The case study's contribution to heritage science showed the process used to restore alto-relievo and mezzo-relief within time, space, and technology limitations.
Quantitative research of street interface morphology in urban historic districts: a case study of west street historic district, Quanzhou
Authors: Huang Kai , Kang Peiran , Zhao Yang
Published: July 2024

Historical urban districts are imbued with a multitude of elements, including historical heritage, cultural significance, social relationships, and daily activities, making them of significant research value. Through a review of previous literature, it is evident that research on the protection and renewal of historical urban districts has mostly focused on macro-level planning and development. Addressing the lack of spatial morphology quantification research at the meso-level, this paper proposes a method suitable for quantifying interface morphology in historical streets. Using the historical cultural street district of Xijie in Quanzhou, Fujian Province as a case study, this research employs parameters such as Distance-Height Ratio, Interface Density, Build-To-Line Rate, and Near-Line Rate to quantify and summarize the morphology of street interfaces. It then proposes transformation strategies to guide the protection and renewal of streets in the future. The study validates the feasibility of this quantification method and provides valuable insights for the protection and renewal of historical urban districts.
3D airway geometry analysis of factors in airway navigation failure for lung nodules
Authors: Cho Hwan-ho , Choe Junsu , Kim Jonghoon , Oh Yoo Jin , Park Hyunjin , Lee Kyungjong , Lee Ho Yun
Published: July 2024

Background

This study aimed to quantitatively reveal contributing factors to airway navigation failure during radial probe endobronchial ultrasound (R-EBUS) by using geometric analysis in a three-dimensional (3D) space and to investigate the clinical feasibility of prediction models for airway navigation failure.

Methods

We retrospectively reviewed patients who underwent R-EBUS between January 2017 and December 2018. Geometric quantification was analyzed using in-house software built with open-source python libraries including the Vascular Modeling Toolkit (http://www.vmtk.org), simple insight toolkit (https://sitk.org), and sci-kit image (https://scikit-image.org). We used a machine learning-based approach to explore the utility of these significant factors.

Results

Of the 491 patients who were eligible for analysis (mean age, 65 years +/- 11 [standard deviation]; 274 men), the target lesion was reached in 434 and was not reached in 57. Twenty-seven patients in the failure group were matched with 27 patients in the success group based on propensity scores. Bifurcation angle at the target branch, the least diameter of the last section, and the curvature of the last section are the most significant and stable factors for airway navigation failure. The support vector machine can predict airway navigation failure with an average area under the curve of 0.803.

Conclusions

Geometric analysis in 3D space revealed that a large bifurcation angle and a narrow and tortuous structure of the closest bronchus from the lesion are associated with airway navigation failure during R-EBUS. The models developed using quantitative computer tomography scan imaging show the potential to predict airway navigation failure.