bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury
Authors: Welsbie Derek S. , Ziogas Nikolaos K. , Xu Leyan , Kim Byung-Jin , Ge Yusong , Patel Amit K. , Ryu Jiwon , Lehar Mohamed , Alexandris Athanasios S. , Stewart Nicholas , Zack Donald J. , Koliatsos Vassilis E.
Published: November 2019

Background

Traumatic brain injury (TBI) is a major cause of CNS neurodegeneration and has no disease-altering therapies. It is commonly associated with a specific type of biomechanical disruption of the axon called traumatic axonal injury (TAI), which often leads to axonal and sometimes perikaryal degeneration of CNS neurons. We have previously used genome-scale, arrayed RNA interference-based screens in primary mouse retinal ganglion cells (RGCs) to identify a pair of related kinases, dual leucine zipper kinase (DLK) and leucine zipper kinase (LZK) that are key mediators of cell death in response to simple axotomy. Moreover, we showed that DLK and LZK are the major upstream triggers for JUN N-terminal kinase (JNK) signaling following total axonal transection. However, the degree to which DLK/LZK are involved in TAI/TBI is unknown.

Methods

Here we used the impact acceleration (IA) model of diffuse TBI, which produces TAI in the visual system, and complementary genetic and pharmacologic approaches to disrupt DLK and LZK, and explored whether DLK and LZK play a role in RGC perikaryal and axonal degeneration in response to TAI.

Results

Our findings show that the IA model activates DLK/JNK/JUN signaling but, in contrast to axotomy, many RGCs are able to recover from the injury and terminate the activation of the pathway. Moreover, while DLK disruption is sufficient to suppress JUN phosphorylation, combined DLK and LZK inhibition is required to prevent RGC cell death. Finally, we show that the FDA-approved protein kinase inhibitor, sunitinib, which has activity against DLK and LZK, is able to produce similar increases in RGC survival.

Conclusion

The mitogen-activated kinase kinase kinases (MAP3Ks), DLK and LZK, participate in cell death signaling of CNS neurons in response to TBI. Moreover, sustained pharmacologic inhibition of DLK is neuroprotective, an effect creating an opportunity to potentially translate these findings to patients with TBI.
A forgotten group during humanitarian crises: a systematic review of sexual and reproductive health interventions for young people including adolescents in humanitarian settings
Authors: Jennings Lauren , George Asha S. , Jacobs Tanya , Blanchet Karl , Singh Neha S.
Published: November 2019

Background

Young people including adolescents face barriers to healthcare and increased risk of poor sexual and reproductive health (SRH), which are exacerbated in humanitarian settings. Our systematic review assessed the evidence on SRH interventions for young people including adolescents in humanitarian settings, strategies to increase their utilisation and their effects on health outcomes.

Methods

We searched peer-reviewed and grey literature published between 1980 and 2018 using search terms for adolescents, young people, humanitarian crises in low- and middle- income countries and SRH in four databases and relevant websites. We analysed literature matching pre-defined inclusion criteria using narrative synthesis methodology, and appraised for study quality.

Findings

We found nine peer-reviewed and five grey literature articles, the majority published post-2012 and mostly high- or medium-quality, focusing on prevention of unintended pregnancies, HIV/STIs, maternal and newborn health, and prevention of sexual and gender-based violence. We found no studies on prevention of mother-to-child transmission (PMTCT), safe abortion, post-abortion care, urogenital fistulae or female genital mutilation (FGM). Thirteen studies reported positive effects on outcomes (majority were positive changes in knowledge and attitudes), seven studies reported no effects in some SRH outcomes measured, and one study reported a decrease in number of new and repeat FP clients. Strategies to increase intervention utilisation by young people include adolescent-friendly spaces, peer workers, school-based activities, and involving young people.

Discussion

Young people, including adolescents, continue to be a neglected group in humanitarian settings. While we found evidence that some SRH interventions for young people are being implemented, there are insufficient details of specific intervention components and outcome measurements to adequately map these interventions. Efforts to address this key population’s SRH needs and evaluate effective implementation modalities require urgent attention. Specifically, greater quantity and quality of evidence on programmatic implementation of these interventions are needed, especially for comprehensive abortion care, PMTCT, urogenital fistulae, FGM, and for LGBTQI populations and persons with disabilities. If embedded within a broader SRH programme, implementers and/or researchers should include young people-specific strategies, targeted at both girls/women and boys/men where appropriate, and collect age- and sex-disaggregated data to help ascertain if this population’s diverse needs are being addressed.
Interaction between ELMO1 gene polymorphisms and environment factors on susceptibility to diabetic nephropathy in Chinese Han population
Authors: Hou Yi , Gao Yong , Zhang Yan , Lin Si-Tong , Yu Yue , Yang Liu
Published: November 2019

Background

The association of diabetic nephropathy (DN) risk with single nucleotide polymorphisms (SNPs) within Engulfment and Cell Motility 1 (ELMO1) gene and gene–environment synergistic effect have not been extensively examined in, therefore, the purpose of this study is to explore the association between multiple SNPs in ELMO1 gene, and the relationship between gene–environment synergy effect and the risk of DN.

Methods

Genotyping for 4 SNPs was performed with polymerase chain reaction (PCR) and following restriction fragment length polymorphism (RFLP) methods. Hardy–Weinberg balance of the control group was tested by SNPstats (online software: http://bioinfo.iconologia.net/snpstats). The best combination of four SNPs of ELMO1 gene and environmental factors was screened by GMDR model. Logistic regression was used to calculating the OR values between different genotypes of ELMO1 gene and DN.

Results

The rs741301-G allele and the rs10255208-GG genotype were associated with an increased risk of DN risk, adjusted ORs (95% CI) were 1.75 (1.19–2.28) and 1.41 (1.06–1.92), respectively, both p-values were < 0.001. We also found that the others SNPs-rs1345365 and rs7782979 were not significantly associated with susceptibility to DN. GMDR model found a significant gene–alcohol drinking interaction combination (p = 0.0107), but no significant gene–hypertension interaction combinations. Alcohol drinkers with rs741301-AG/GG genotype also have the highest DN risk, compared to never drinkers with rs741301-AA genotype, OR (95% CI) 3.52 (1.93–4.98).

Conclusions

The rs741301-G allele and the rs10255208-GG genotype, gene–environment interaction between rs741301 and alcohol drinking were all associated with increased DN risk.
Fasting triglycerides and glucose index: a useful screening test for assessing insulin resistance in patients diagnosed with rheumatoid arthritis and systemic lupus erythematosus
Authors: Contreras-Haro Betsabe , Hernandez-Gonzalez Sandra Ofelia , Gonzalez-Lopez Laura , Espinel-Bermudez Maria Claudia , Garcia-Benavides Leonel , Perez-Guerrero Edsaul , Vazquez-Villegas Maria Luisa , Robles-Cervantes Jose Antonio , Salazar-Paramo Mario , Hernandez-Corona Diana Mercedes , Nava-Zavala Arnulfo Hernan , Gamez-Nava Jorge I.
Published: November 2019

Background

Insulin resistance (IR) is frequently observed in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). In clinical practice, IR assessment is limited to a low proportion of patients due to cost and equipment and technical expertise requirements. The surrogate index of triglycerides and glucose (TyG index) has been validated in non-rheumatic populations, showing adequate sensitivity and specificity for IR, although this index has not yet been used in connective tissue disorders. The aim of this study was to evaluate the frequency of insulin resistance (IR) using the validated surrogate index of triglycerides and glucose (TyG index) and to explore factors associated with IR in Mexican women with RA or SLE.

Methods

Ninety-five female RA and 57 SLE patients were included in a cross-sectional study. Clinical and epidemiological variables were evaluated. IR was assessed using the TyG index with a cutoff value of > 4.68. Logistic regression analysis was performed to identify factors associated with IR excluding confounders.

Results

IR frequency in the entire sample was 50%, higher than the 10% observed in non-rheumatic controls (p < 0.001). The frequency of IR was similar in SLE (49.1%) and RA (50.5%, p = 0.8) patients. IR was associated with a longer duration of hypertension and higher total cholesterol and low density lipoprotein cholesterol levels. Based on multivariate analysis, the duration of hypertension (OR: 1.06; 95% CI 1.002–1.12, p = 0.04), waist circumference (OR: 1.04; 95% CI 1.01–1.08, p = 0.007), uric acid levels (OR: 1.46; 95% CI 1.08–1.97, p = 0.01), RA (OR: 4.87; 95% CI 1.31–18.78, p = 0.01) and SLE (OR: 4.22; 95% CI 1.06–16.74, p = 0.04) were the main risk factors for IR.

Conclusions

This study shows that the TyG index is a useful screening test for IR in RA and SLE patients. Future longitudinal studies should be performed with the aim of identifying the predictive value of TyG index results for identifying complications linked to IR.
Adult-onset linear discoid lupus erythematosus on the forehead mimicking en coup de sabre: a case report
Authors: Sindhusen Sasipaka , Chanprapaph Kumutnart , Rutnin Suthinee
Published: November 2019

Background

Linear cutaneous lupus erythematosus (LE) is an unusual form of LE-specific cutaneous condition, occurring in children and young adults. Due to its rarity, the diagnosis of linear cutaneous LE can be difficult and facial lesions can resemble linear morphea or en coup de sabre. Differential diagnosis of similar conditions along the lines of Blaschko must be differentiated from linear LE.

Case presentation

We report a case of linear discoid LE on the forehead of an adult female Thai patient mimicking en coup de sabre. The dermatoscopy, histopathology and direct immunofluorescence findings were consistent with chronic cutaneous LE.

Conclusions

As this patient demonstrated classic dermatoscopic features of LE, we emphasized that the diagnosis of linear cutaneous LE can be made by dermatoscopy. This is particularly beneficial for young self-conscious patients with facial lesions that are reluctant to perform skin biopsy.
PAPR reduction in LTE network using both peak windowing and clipping techniques
Authors: Musabe Richard , Lionel Mafrebo B. , Mugongo Ushindi Victoire , Atupenda Mugisha , Ntaganda James , Bajpai Gaurav
Published: November 2019

Multicarrier technique orthogonal frequency division multiplexing (OFDM) modulation is a solution to provide high-speed and secured data transmission requirement in 4G technologies. Peak-to-average power ratio (PAPR) is one major drawback in OFDM system. Researches described several PAPR reduction techniques, notably peak windowing and clipping. The aim of this paper is to use these techniques to reduce PAPR. The research work describes clipping and windowing techniques such as quadratic amplitude modulation (QAM) and additive white Gaussian noise (AWGN) as channel condition. The simulation results show that in those techniques with clipping threshold level of 0.7, there is a reduction of PAPR of 8 dB, and the reduction of PAPR for the peak windowing when considering Kaiser window is about 11 dB.
Perinatal mental health around the world: priorities for research and service development in Italy
Authors: Grussu Pietro , Lega Ilaria , Quatraro Rosa Maria , Donati Serena
Published: November 2019

In Italy, most studies on perinatal mental health and initiatives aimed at improving the early detection and management of perinatal mental disorders have been carried out at the local level. National population-based studies are lacking. A study of pregnant women, recruited and diagnosed by a university hospital, found a 12.4% prevalence of minor and major depression during pregnancy, and a prevalence of 9.6% in the postpartum period. In a population-based surveillance system, covering 77% of national births, suicide was identified to be one of the main causes of maternal death within the first year after birth, yet half of those who were known to have a high suicide risk during the postpartum period had not been referred to a mental health service. The value of recognising depressive or anxiety symptoms early, during pregnancy, has been emphasised by recent research and should be linked to multi-professional psychosocial interventions. Since 2017, the Italian public primary care services that are dedicated to pregnancy assistance (Family Care Centres) have been tasked to provide free psychological assessment to pregnant and postpartum women. Action is now needed in order to improve access to Italian Family Care Centres for pregnant women and to develop an integrated care model involving obstetric and mental health services.
Cluster Randomized Trial to Facilitate Breast Cancer Early Diagnosis in a Rural District of Rwanda
Authors: Pace Lydia E. , Dusengimana Jean Marie Vianney , Shulman Lawrence N. , Schleimer Lauren E. , Shyirambere Cyprien , Rusangwa Christian , Muvugabigwi Gaspard , Park Paul H. , Huang ChuanChin , Bigirimana Jean Bosco , Hategekimana Vedaste , Rugema Vestine , Umwizerwa Aline , Keating Nancy L. , Mpunga Tharcisse
Published: November 2019

PURPOSE

Feasible and effective strategies are needed to facilitate earlier diagnosis of breast cancer in low-income countries. The goal of this study was to examine the impact of health worker breast health training on health care utilization, patient diagnoses, and cancer stage in a rural Rwandan district.

METHODS

We conducted a cluster randomized trial of a training intervention at 12 of the 19 health centers (HCs) in Burera District, Rwanda, in 2 phases. We evaluated the trainings’ impact on the volume of patient visits for breast concerns using difference-in-difference models. We used generalized estimating equations to evaluate incidence of HC and hospital visits for breast concerns, biopsies, benign breast diagnoses, breast cancer, and early-stage disease in catchment areas served by intervention versus control HCs.

RESULTS

From April 2015 to April 2017, 1,484 patients visited intervention HCs, and 308 visited control HCs for breast concerns. The intervention led to an increase of 4.7 visits/month for phase 1 HCs ( P = .001) and 7.9 visits/month for phase 2 HCs ( P = .007) compared with control HCs. The population served by intervention HCs had more hospital visits (115.1 v 20.5/100,000 person-years, P < .001) and biopsies (36.6 v 8.9/100,000 person-years, P < .001) and higher breast cancer incidence (6.9 v 3.3/100,000 person-years; P = .28). The incidence of early-stage breast cancer was 3.3 per 100,000 in intervention areas and 0.7 per 100,000 in control areas ( P = .048).

CONCLUSION

In this cluster randomized trial in rural Rwanda, the training of health workers and establishment of regular breast clinics were associated with increased numbers of patients who presented with breast concerns at health facilities, more breast biopsies, and a higher incidence of benign breast diagnoses and early-stage breast cancers.
A Meta-Analysis of Pregnancy Outcomes With Levothyroxine Treatment in Euthyroid Women With Thyroid Autoimmunity
Authors: Sun Xiaodong , Hou Ningning , Wang Hongsheng , Ma Lin , Sun Jinhong , Liu Yongping
Published: November 2019

Context

Thyroid autoimmunity (TAI), the most common cause of (sub)clinical hypothyroidism, is associated with adverse pregnancy outcomes. The benefits of levothyroxine (LT4) intervention in women with TAI remain controversial.

Objective

The purpose of this analysis is to determine the effect of LT4 on pregnancy outcomes in euthyroid women with TAI.

Data sources

Databases were searched up to May 2019.

Study selection

Randomized controlled trails (RCTs) and retrospective studies that reported effects of LT4 administration on pregnancy outcomes in euthyroid women with TAI were screened.

Data extraction

Quality assessment and data extraction were conducted independently by 2 researchers. Conflicts were settled by a third researcher.

Data synthesis

Six trials comprising 2249 women were included. Overall, no beneficial effect on pregnancy outcomes was observed with LT4 supplementation. For women with individualized initial LT4 dosages, the risk of miscarriage decreased (relative risk [RR] 0.62, 95% CI: 0.41-0.93, I2 = 28%); there was no difference among women with fixed LT4 dosages (RR 0.96, 95% CI: 0.74-1.24, I2 = 0%). Women who initiated LT4 treatment in early pregnancy had a significantly lower preterm birth rate (RR 0.54, 95% CI: 0.31-0.92, I2 = 0%) than those who received no treatment or placebo. No improvement was observed among women who initiated treatment before conception (RR 1.14, 95% CI: 0.71-1.84, I2 = 0%).

Conclusion

No definitive evidence showed improvement of pregnancy outcomes with LT4 supplementation in euthyroid women with TAI. However, therapeutic strategies, especially dosages and initial times of intervention, may be of great importance. Additional large RCTs are needed in the future.
Impact of Race on the Association of Mineral Metabolism With Heart Failure: the Multi-Ethnic Study of Atherosclerosis
Authors: Robinson-Cohen Cassianne , Shlipak Michael , Sarnak Mark , Katz Ronit , Peralta Carmen , Young Bessie , Hoofnagle Andrew N , Szklo Moyses , Ix Joachim H , Psaty Bruce M , de Boer Ian H , Kestenbaum Bryan , Bansal Nisha
Published: November 2019

Background

Alterations in mineral metabolism, such as high phosphorus, high parathyroid hormone (PTH), and high fibroblast growth factor-23 (FGF-23) have been identified as potential risk factors for heart failure (HF). Important differences in the prevalence of mineral metabolism abnormalities and in the risk of HF have been reported across race and/or ethnic groups. In this study, we evaluated whether the associations of mineral metabolism markers with HF differed by race and/or ethnicity.

Methods

We included participants free of cardiovascular disease from the Multi-Ethnic Study of Atherosclerosis to quantify rates of HF overall and across race and/or ethnic groups. Using Cox models, we tested associations of baseline higher phosphorus (>4 mg/dL), PTH greater than 65 pg/mL, and FGF-23 greater than 46.5 pg/mL with incident HF, and for interactions by race and/or ethnicity, adjusting for sociodemographic and cardiovascular risk factors.

Results

Among the 6413 participants, median follow-up time was 14.9 years. The incidence rate for HF was highest for African Americans and lowest for Chinese (4.71 and 2.42 per 1000 person-years, respectively). The prevalence of elevated PTH (18.8% vs 7.4%) but not FGF-23 (23.1% vs 28.8%) was higher in African Americans vs Whites. In multivariable models, the associations of elevated PTH (hazard ratio [HR] 1.50, 95% CI: 1.13-1.99) and FGF-23 (HR 1.37, 95% CI: 1.07-1.75) with incident HF were statistically significant. However, the interactions by race and/or ethnicity were not statistically significant.

Conclusions

In a multiethnic population, higher PTH and FGF-23 were associated with risk of HF in African American and Hispanic individuals. There is no evidence that race and/or ethnicity modifies the association of altered mineral metabolism with risk of HF.
Clearing the Fog: The Predictive Power of Weather for Employment Reports and Their Asset Price Responses
Authors: Wilson Daniel J.
Published: November 2019

This paper exploits vast granular data—with over one million county-month observations—to estimate a dynamic panel data model of weather’s local employment effects. The fitted county model is then aggregated and used to generate in-sample and rolling out-of-sample (nowcast) estimates of the weather effect on national monthly employment. These nowcasts, which use only employment and weather data available prior to a given employment report, are significantly predictive not only of the surprise component of employment reports but also of stock and bond market returns on the days of employment reports. (JEL C53, G12, G17, H63, Q54, R23)
Discriminating against Captive Customers
Authors: Armstrong Mark , Vickers John
Published: November 2019

We analyze a market where some consumers only consider buying from a specific seller while other consumers choose the best deal from several sellers. When sellers are able to discriminate against their captive customers, we show that discrimination harms consumers in aggregate relative to the situation with uniform pricing when sellers are approximately symmetric, while the practice tends to benefit consumers in sufficiently asymmetric markets. We also show how the asymmetry of markets may be affected by the information that firms have on consumer captivity. (JEL D11, D43, D83, L13)
Clozapine-induced myocarditis during co-administration of valproate: A case report
Authors: Jahołkowski Piotr , Niewiadomska Julita , Wciórka Jacek , Kowalski Mirosław , Świtaj Piotr
Published: November 2019

Klozapina, atypowy lek przeciwpsychotyczny, znajduje powszechne zastosowanie w terapii osób chorujących na schizofrenię, u których dotychczasowe leczenie było nieskuteczne lub źle tolerowane. Zapalenia mięśnia sercowego indukowane klozapiną (clozapine-induced myocarditis – CIM) jest relatywnie rzadkim, ale potencjalnie zagrażającym życiu powikłaniem leczenia klozapiną, którego patomechanizm pozostaje nieznany. Czynnikami predysponującymi do rozwoju CIM jest gwałtowne zwiększanie dawki leku, równoległe leczenie walproinianem sodu oraz zaawansowany wiek. Prezentujemy przypadek 22-letniego mężczyzny z rozpoznaniem schizofrenii lekoopornej, u którego w przebiegu leczenia niewielką dawką klozapiny, pochodnymi kwasu walproinowego oraz risperidonem stwierdzono wystąpienie CIM. Na podstawie opisywanej sytuacji klinicznej oraz analizy dostępnej literatury wskazujemy, że w pierwszych tygodniach od wdrożenia klozapiny, pacjenci powinni być codziennie aktywnie oceniani pod kątem obecności objawów sugerujących rozwój CIM. Niewielka dawka przyjmowanej klozapiny oraz jednoczesne stosowanie walproinianów stanowią unikalne aspekty opisywanego przypadku, wpisując się w dyskusję na temat bezpieczeństwa jednoczesnego stosowania klozapiny oraz walproinianów. Ocena udziału walproinianów oraz risperidonu w patogenezie CIM wymaga dalszych badań.
Editorial
Authors: Dudek Dominika , Sobański Jerzy , Klasa Katarzyna
Published: November 2019

bez streszczenia
The evaluation of effect of selected metal ions on the efficiency of passive and active transport of imipramine
Authors: Opoka Włodzimierz , Kryczyk Agata , Krakowska Agata , Piotrowska Joanna , Gdula-Argasińska Joanna , Kała Katarzyna , Linek Marlena , Muszyńska Bożena
Published: November 2019

Cel pracy

Celem pracy była ocena wpływu jonów cynku, magnezu lub miedzi na skuteczność transportu biernego chlorowodorku imipraminy w modelu in vitro. Na podstawie wyników uzyskanych z eksperymentu dotyczącego transportu biernego, kolejnym celem badań było sprawdzenie skuteczności transportu aktywnego chlorowodorku imipraminy w obecności lub braku jonów cynku.

Metoda

Badanie transportu biernego przeprowadzono w specjalnie skonstruowanych na potrzeby eksperymentu kapsułach, natomiast do oceny transportu aktywnego wykorzystano linię ludzkich komórek CaCo-2. Zawartość cynku, magnezu i miedzi oznaczono metodą F-AAS. W analizie chlorowodorku imipraminy zastosowano metodę HPLC.

Wyniki

Średnie stężenia jonów cynku, magnezu i miedzi uzyskane w tym doświadczeniu wynosiły odpowiednio: 2,98, 1,34 i 3,52 mg/L. Wydajność transportu aktywnego chlorowodorku imipraminy w obecności jonów cynku zwiększyła się o 39%. Ponadto transport jonów cynku w obecności chlorowodorku imipraminy był o 27% większy niż w przypadku roztworów zawierających cynk bez chlorowodorku imipraminy. Wydłużenie czasu eksperymentu z 30 do 60 minut spowodowało wzrost efektywności transportu o ponad 10% w obu przypadkach.

Wnioski

Stwierdzono, że na wydajność transportu biernego i aktywnego chlorowodorku imipraminy wpływa obecność jonów Mg, Zn i Cu. W obecności jonów miedzi i cynku transport bierny chlorowodorku imipraminy po 90 minutach doświadczenia był najefektywniejszy. Dalsze badania prowadzone na linii komórkowej CaCo-2 wykazały wyraźną pozytywną interakcję imipramina - cynk.
Adaptation of the Body Image Self-Consciousness Scale (BISC-PL) in Polish females
Authors: Szymańska-Pytlińska Marta
Published: November 2019

Cel pracy

Artykuł prezentuje polską wersję skali Body Image Self-Consciousness (BISC-PL) autorstwa Wiedermana.

Metoda

Własności psychometryczne BISC-PL zweryfikowano w próbie 169 heteroseksualnych, młodych kobiet w wieku 18-35 lat (M=22,24, SD=3,61). Dla zbadania trafności teoretycznej polskiej wersji skali dokonano również pomiaru samooceny seksualnej, zadowolenia z ciała, doświadczeń heteroseksualnych, obserwacyjnej samokontroli i innych zmiennych.

Wyniki

Konfirmacyjna analiza czynnikowa (z funkcją dopasowania WLSMV) potwierdziła jednoczynnikową strukturę BISC-PL. Współczynniki dobroci dopasowania modelu wyniosły CFI=,91, TLI=,90, RMSEA=,06, SRMR=,05. W większości przypadków analizy z użyciem wspomnianych wyżej zmiennych potwierdziły trafność teoretyczną adaptowanego narzędzia. Wyniki BISC-PL pozwalały przewidywać poziom samooceny seksualnej i ocenę siebie w roli partnera seksualnego badanych kobiet, wykraczając poza efekty wynikające z ich zadowolenia z ciała i oceny atrakcyjności własnego ciała. Narzędzie okazało się rzetelnym (α=,96) i trafnym wskaźnikiem samoświadomości obrazu ciała podczas fizycznej intymności z partnerem w badanej grupie kobiet.

Wnioski

Polską wersję narzędzia można uznać za porównywalną do wersji oryginalnej. BISC-PL może być rekomendowany jako użyteczne narzędzie uzupełniające polskie badania i praktykę. Wyniki przeprowadzonych analiz omówiono pod kątem ich ograniczeń i wskazano na przyszłe kierunki badań.
Creutzfeldt-Jakob disease mimicking Lewy body dementia – a case report
Authors: Nesteruk Marta , Nesteruk Tomasz , Ułamek-Kozioł Marzena , Holak-Puczyńska Anna , Dorobek Małgorzata
Published: November 2019

Otępienie z ciałami Lewy'ego jak również choroba Creutzfeldta- Jakoba rozpoznawane są na podstawie określonych kryteriów diagnostycznych. Jednakże wspólne objawy dla obu chorób takie jak : zespół otępienny, zespół pozapiramidowy, zaburzenia psychotyczne mogą sprawiać trudności diagnostyczne zwłaszcza w początkowej fazie choroby. Każda z tych chorób może mieć nietypowy początek, a dopiero dalszy jej przebieg i pojawienie się kolejnych objawów wskazuje właściwe rozpoznanie. Pomocne w diagnostyce różnicowej są badania dodatkowe, przede wszystkim elektroencefalogram, badanie płynu mózgowo-rdzeniowego pod kątem białka 14-3-3.
Przedstawiamy przypadek 66-letniej pacjentki, u której początkowo podejrzewaliśmy otępienie z ciałami Lewy'ego. Przy przyjęciu w badaniu neurologicznym stwierdzono spowolnienie psychoruchowe, dyzartrię, niewielką dysmetrię kończyn górnych, wzmożone pozapiramidowo napięcie w kończynach górnych , ataksję kończyn dolnych, powolny chód, chwiejną próbę Romberga. W skali przesiewowej MMSE 24 punkty, w badaniu neuropsychologicznym: początkowe stadium otępienia, objawy lękowo-depresyjne z okresowymi elementami wytwórczymi wzrokowo-słuchowymi. Po niespełna 3 tygodniach nastąpiło pogorszenie stanu neurologicznego: stwierdzono większe spowolnienie psychoruchowe, nasilenie dyzartrii, wystąpienie ataksji tułowia oraz nasilenie ataksji kończyn dolnych. Stwierdzono również znaczną progresję zaburzeń poznawczych, pełne badanie neuropsychologiczne było niemożliwe do wykonania, spadek w MMSE z 24 do 12 punktów.
Przebieg choroby u naszej pacjentki oraz wyniki badań dodatkowych potwierdziły obecność sporadycznej postaci choroby Creutzfeldta- Jakoba.
Innovation and New Product Development: Reflections and Insights from the Research Published in the First 20 Years of Manufacturing & Service Operations Management
Authors: Kavadias Stylianos , Ulrich Karl T.
Published: November 2019

In this short essay, we reflect on the innovation-related studies that have appeared in Manufacturing & Service Operations Management (M&SOM) in its first 20 years of publication and consider the future work that M&SOM could publish in this domain. Innovation management can be defined broadly enough to encompass the efforts of organizations to effectively design and develop novel solutions to existing or new needs. Several different approaches and thematic lenses have emerged in the academic community to address diverse questions in innovation management; however, the work published in M&SOM has a narrow focus. This gap reveals an opportunity for the M&SOM community, which may be addressed in part by improvements in the review process of the journal. We also suggest some specific innovation topics that the researchers in the community might tackle.
A razão negra e o projeto romântico: dupla face do romance Úrsula (1859), de Maria Firmina dos Reis
Authors: Oliveira Luiz Henrique Silva de
Published: November 2019

Este estudo pretende analisar o romance Úrsula (1859), de Maria Firmina dos Reis, a partir do conceito de “razão negra”, formulado por Achille Mbembe (2014), em contraste com a estética romântica que também ampara o livro da autora brasileira. E, além disso, objetiva-se discutir como este conceito de Mbembe ajuda a compreender a representação do negro realizada pelo texto firminiano. Para Mbembe, a “razão negra” liga-se à fabricação das imagens do saber e do sujeito afrodescendente. A hipótese deste ensaio é que a “razão negra” opera como dispositivo responsável por potencializar a compreensão de imagens de afrodescendentes no romance Úrsula, tais como exemplificadas por meio das trajetórias de Túlio, Mãe Susana e Antero. Se, por um lado, o livro em questão opta por seguir as linhas gerais do romantismo brasileiro, ao discutir a configuração da nação e a escravidão, por outro lado ele o faz a partir dos paradigmas identitários pautados pela “razão negra”, ou seja, o negro como sujeito das ações e do discurso.
Seroprevalence and risk factors of bovine respiratory syncytial virus in cattle in the Nineveh Governorate, Iraq
Authors: Hussain Khder Jassiem , Al-Farwachi Maab Ibrahim , Hassan Sadam Dhahir
Published: November 2019

Background and Aim: Bovine respiratory syncytial virus (BRSV) is one of the main causes of severe pneumonia, interstitial edema, and emphysema in cattle. The current study investigated the prevalence and risk factors of BRSV in cattle in the Nineveh Province, Iraq.

Materials and Methods: Between September 2017 and September 2018, 450 serum samples were collected from non-vaccinated cattle of different ages and breeds for BRSV testing. The epidemiological information of the animals was recorded. The prevalence of the disease was determined using an indirect enzyme-linked immunosorbent assay kit.

Results: The prevalence of BRSV was 83.11%, and it was significantly (p<0.05) higher in cattle aged greater than 7 months-1.5 years than in older animals; in imported cattle than in Native animals; and in animals originating from large herds (100 animals) than in those from smaller herds (40 animals). There was no significant difference between BRSV prevalence in male and female animals. When samples from different regions of the Nineveh Governorate were compared, the northern region was associated with the highest prevalence of the disease. Samples harvested in the winter displayed the highest BRSV titer, compared to those collected during the other seasons.

Conclusion: BRSV is prevalent in cattle from the Nineveh Governorate. Risk factors such as animal age, origin, herd size, and the herd's geographical location are associated with an increased prevalence of the disease in this region. Routine vaccination programs should be adopted to reduce the prevalence of BRSV.
Apendicectomía laparoscópica vs. abierta en pediatría, análisis de complicaciones
Authors: Angelo Loochkartt , Bravo Katherine
Published: November 2019

Introducción: El papel de la laparoscopia en el manejo de la apendicitis aguda ya tiene un papel establecido, con los beneficios tanto clínicos como de costos hospitalarios, sin embargo en nuestro medio se requieren estudios que evalúen los resultados de la laparoscopia para el manejo de apendicitis aguda en niños.Objetivo: Hacer una comparación de los resultados clínicos entre la apendicectomía laparoscópica vs abierta en el Hospital Infantil San Vicente Fundación, y analizar las complicaciones de estas dos técnicas quirúrgicasMetodología: Es un estudio retrospectivo que incluye a todos los pacientes entre los 6 meses a los 14 años de edad con diagnóstico de apendicitis aguda que se les realizó una apendicectomía laparoscópica o abierta desde Mayo de 2014-Mayo de 2016. Se recolectaron los diferentes datos y se analizaron usando modelos para variables continuas; se estableció un valor de alfa < 0.05 para una significancia estadística.Resultados: Se realizaron 517 apendicectomías (con una media de 4,9 apendicectomías por semana, 1,4 laparoscópicas y 3,51 abiertas). El 29 % (n=151) de las apendicectomías se realizaron por vía laparoscópica (LA) y el 71 % (n=366) fueron apendicectomías abiertas (AA). Las complicaciones en LA corresponden al 9,93 % (n=15), la infección de sitio operatorio superficial corresponde al 3,31 % (n=5). La infección de sitio operatorio profunda al 3,31 % (n=5). La dehiscencia de muñón apendicular 1,98 % (n=3) Las complicaciones en AA corresponden al 18,30 % (n=67).La infección de sitio operatorio superficial corresponde al 10,68 % (n=39). La infección de sitio operatorio profunda al 4,64 % (n=17). Se presentaron 2 casos de dehiscencia de muñón apendicular. La estancia hospitalaria para los pacientes intervenidos por laparoscopia tiene una media de 3,7 días, y en la apendicectomía abierta una media de 4,11 días.Conclusiones: La apendicectomía por laparoscopia ofrece ventajas significativas en el tratamiento de la apendicitis aguda, frente a la apendicectomía abierta. Quienes más se benefician son los pacientes con apendicitis complicada; se observan menos comorbilidades, un inicio temprano de la vía oral, menos complicaciones postquirúrgicas como el desarrollo de colecciones y menor número de reintervenciones por obstrucción intestinal , lo que se traduce directamente en una reducción de la estancia hospitalaria y de los costos para el sistema de salud.
Forthcoming events
Authors: Papier Joy
Published: November 2019

1) CONFERENCE: POSTGRADUATE STUDENTS IN TVET STUDIES: 20–22 November 2019

The Editor-in-Chief of JOVACET and NRF Chair: TVET Studies, Prof. Joy Papier, is hosting a conference for Master’s and Doctoral students in TVET-focused studies, to be held at UWC, from 20–22 November 2019. Venue: School of Public Health

2) ‘WRITING FOR PUBLICATION’ SEMINAR: 22 November 2019

Prof. Simon McGrath (Nottingham University), author of a number of TVET-focused books and articles, a member of the JOVACET Editorial Committee and Extraordinary Professor to the IPSS, will facilitate a ‘writing for publication’ seminar for prospective JOVACET authors, on 22 November 2019 from 09:00 to 12:00, as part of the conference programme mentioned above.

3) NEXT JOURNAL WRITING WORKSHOP: 15 December 2019

A writing workshop for prospective JOVACET authors, who have papers already in draft, will be held in February/March 2020. Details to be advised in due course.
Call for papers, Vol 3, Issue 1, 2020
Authors: Robertson Catherine
Published: November 2019

You are invited to submit an abstract for JOVACET Volume 3, Issue 1, 2020, which will be a Special Edition with a specific focus on teacher education in technical and vocational education and training, to be published in September 2020.

Deadline for abstract submissions: Friday, 14 February 2020.
Contributor biographies
Authors: Papier Joy
Published: November 2019

Antje Barabasch, Dominic Caldart and Anna Keller

Aasief Gaffoor and André van der Bijl

Zelda Groener and Priscilla Andrews

André Kraak

Seamus Needham

Martin J Mulcahy
Acknowledgements
Authors: Papier Joy
Published: November 2019

We once again acknowledge our reviewers for the insight and developmental critique which they so unstintingly offered. Each journal article is anonymised and subjected to ‘blind’ peer review by two reviewers and, in this process, it is inevitable that variations of interpretation and evaluation occurred, at times resulting in a third reviewer being consulted. We are grateful for the grace with which reviewers engaged and attempted to resolve any sticking points on such occasions. This has served to enhance the quality of our articles and strengthen our authors going forward.

Thanks to all the authors who made submissions to JOVACET and subjected their work to scrutiny. We trust that you will continue to contribute to this important vehicle for research in vocational, adult and continuing education and training.

Finally, the publication of this third issue of JOVACET was made possible by the Teaching and Learning Development Capacity Improvement Programme (TLDCIP) which is being implemented through a partnership between the Department of Higher Education and Training and the European Union. We are grateful for this support to the third issue of the journal, Volume 2, Issue 2.

We look forward to the ongoing support of our Editorial Committee and Advisory Board members who are advocates for JOVACET in the various spheres of their lives, and thank you all most sincerely.
Fundaciones privadas en la educación media pública de Uruguay
Authors: Pereda Cecilia
Published: November 2019

Las fundaciones son uno de los actores que actualmente participan junto al Estado en la educación pública de diferentes países. En este artículo se estudia la participación de tres fundaciones en la educación media pública de Uruguay, un país con alta presencia estatal en la educación formal. Se propone un marco conceptual que articula aproximaciones a las privatizaciones educativas (Ball & Junemann, 2012; Ball & Youdell, 2007; Bellei & Orellana, 2014; Verger & Bonal, 2012) y a los regímenes de bienestar (Adelantado, 1999; Esping Andersen, 1998; Razavi, 2007) del que se desprenden tres dimensiones analíticas: estratégica, espacial y relacional. A partir de entrevistas a sus directores, de la lectura de diversos documentos y de algunas observaciones participantes se examinan las principales características de estas fundaciones y de su trabajo en la educación secundaria del país, las relaciones que establecen con las empresas, con las organizaciones sociales y con el Estado y el tipo de vínculo que  promueven con los estudiantes y los docentes, así como las consecuencias de todo lo anterior para el sentido de lo público en la educación. Los resultados muestran diversidad en la dependencia empresarial así como en su integración a la educación pública de Uruguay. Advierten también sobre algunas tensiones que el Estado debe resolver para que la participación de las fundaciones amplíe y no obstaculice la construcción de los valores asociados a lo común y lo colectivo en la integración de todos los estudiantes a la educación media.
Estudos sobre formação inicial de professores em Moçambique e sua relação com as políticas de formação de professores (2012-2017)
Authors: Julião Mugime Santa Mónica , Mahalambe Feliciano Mapezuane , Cossa José , Leite Carlinda
Published: November 2019

O artigo dá conta de um estudo que teve como objetivo fazer o estado da arte da investigação produzida em Moçambique sobre a formação inicial de professores (FIP) na sua relação com as políticas de educação. Para isso, foi feito um mapeamento de estudos sobre “Formação inicial de professores em Moçambique”, na forma de artigos científicos e de teses de doutoramento de autoria de moçambicanos, no período compreendido entre 2012 e 2017. Foram identificados, pela internet, 20 artigos, dos quais 7 foram excluídos por não terem sido publicados em revistas ou periódicos. Relativamente às teses de doutoramento, foram identificadas 4. Para a identificação dos artigos e teses recorreu-se ao uso das palavras-chave: formação inicial; professores; Moçambique. A análise das teses e dos artigos permitiu constatar uma diversidade de abordagens sobre a FIP, com ênfase na crítica à diversidade dos modelos de formação de professores, em questões da inclusão escolar e de educação inclusiva, nomeadamente por as intenções dos discursos veiculados nas políticas educativas não estarem a ser correspondidas nos currículos de FIP e na profissionalização da formação de professores.
Uji Stabilitas pH dari Daun Mangga Hasil Ekstraksi Dengan Menggunakan Metode Spektrofotometer
Authors: Elliana Kartika Dian , Broto R.T.D. Wisnu
Published: November 2019

Ekstraksi merupakan proses pemisahan dan isolasi zat dari suatu zat dengan penambahan pelarut tertentu untuk mengeluarkan komponen campuran dari zat padat atau zat cair. Pada penelitian ini dilakukan ekstraksi klorofilid dari daun mangga untuk mengetahui stabilitas reduksi klorofil hasil ekstraksi berupa ekstrak dan rafinat. Ekstraksi klorofilid dilakukan dengan alat ekstraktor berpengaduk yaitu dengan memotong daun mangga 1 cm kemudian di ekstraksi dengan pelarut Aquadest 25%:75% Isopropil Alkohol.  Pemilihan pelarut merupakan faktor yang menentukan dalam proses ekstraksi. Hal-hal yang perlu diperhatikan dalam pemilihan pelarut adalah selektivitas, sifat pelarut, kemampuan untuk mengekstraksi, tidak bersifat racun, mudah diuapkan dan harganya relatif murah. Karakteristik ekstrak klorofilid menggunakan spektrofotometer untuk mengetahui absorbansi klorofil optimum dalam suatu variabel ekstrak dan rafinat serta uji pH untuk mengetahui stabilitas pH yang baik untuk mereduksi klorofil daun mangga. Hasil absorbansi klorofil optimum pada suhu 60OC dan waktu 70 menit pada ekstrak dan hasil stabilitas pH untuk mereduksi klorofil didapatkan pada pH 9 asam serta pH 2 basa.Extraction is the process of separating and isolating substances from a substance by adding a particular solvent to remove a mixed component of a solid or a liquid. In this study, extraction of chlorophyllid from mango leaves to determine the stability of chlorophyll reduction in the extract and raffinate. Extraction of chlorophyllid was done by stirring extractor that is by cutting mango leaves 1 cm then in extraction with Aquadest solvent 25%: 75% Isopropyl Alcohol. Selection of solvents is a decisive factor in the extraction process. Things to note in the selection of solvents are the selectivity, the properties of the solvent, the ability to extract, not toxic, easily evaporated and the price is relatively cheap. Characteristics of chlorophyll extract using spectrophotometer to determine the absorbance of optimum chlorophyll in an extract and raffinate variables and pH test to find out good pH stability to reduce mango leaf chlorophyll. The optimum chlorophyll absorbance results at 60OC and 70 minutes on the extract and the pH stability result to reduce chlorophyll was found at pH 9 acid and pH 2 base.
DIAMONT: a bilingual Android-based application to assist parents in the home-based management of childhood diarrhea – a concept
Authors: Fatimah Vita Arfiana Nurul , Mustafidah Hindayati , Fitri Ardhista Shabrina
Published: November 2019

Diarrhea, defined as passing watery stool for three times or more per 24 h, may affect children’s growth and development and possesses a high mortality rate, particularly among children under 5 years old. Those poor outcomes result from water and electrolyte imbalance and poor nutrition status in children suffering from diarrhea. Management of childhood diarrhea, aiming to prevent dehydration and malnutrition, encompasses those covered in LINTAS DIARE (“Lima Langkah Tuntaskan Diare”) – guidance from the Ministry of Health of Indonesia to overcome childhood diarrhea in five steps. A concept of an Android-based application is designed in both English and Bahasa versions to guide parents as users in a home-based approach to recognize the dehydration status and danger signs of children with diarrhea. The application may also allow users to monitor water balance as well as management adequacy during the diarrhea period. Data such as child’s birth date, weight, and height; stool’s characteristics and frequency; and dehydration and warning signs are required to be input by users to allow the program to classify the dehydration status and suggest recommendation of actions. The advice provided is based on the LINTAS DIARE principles.
Chronillogicalities
: Déjà vus and hallucinations in the digital semiosphere
Authors: Leone Massimo
Published: November 2019

The semiotics of phenomena like déjà vus and hallucinations constitute a limit-field of a theory of the sign, but one that offers opportunities to question the fundamental principles of the discipline while at the same time offering the opportunity to address their underlying cognitive processes. The article describes the cognitive nature of déjà vus and hallucinations, briefly reviews the literature about them, and reads them as cognitive perturbations in the light of a semiotics of mental simulacra related to perception, apperception, awareness, memory, and imagination. The article then uses such cognitive and semiotic modeling in order to develop a critique of present-day digital culture, in which the uncritical adoption of a mnemonic ideal based on digital memory jeopardizes one of the key features of embodied memory: imperfection and, as a consequence, the possibility to access aesthetic and temporal singularity. A collective memory prone to déjà vus and hallucinations ensues.
For a new semiotics in Construction Grammar: A statistical analysis of the relationship between transitive syntax and semantics
Authors: Lepesqueur Marcus , Tenuta Adriana Maria
Published: November 2019

By extending the notion of constructions beyond “irregular” structures, Goldberg (1995.Constructions: A construction grammar approach to argument structure. Chicago: University of Chicago Press) made possible the analysis of clause units as a global pattern associating syntax to principles for semantic interpretation. Despite this theoretical advance, Construction Grammar’s pairing of syntactic structure and conceptual form reflects Saussure’s signifier/signified semiotic model, which poses some issues. Problems arise when a single formal structure expresses distinct semantic patterns or, conversely, when semantics persists notwithstanding formal variation. In order to approach this unstable syntax/semantics interface, this work proposes a statistical methodology to capture the correlation between syntax and Hopper and Thompson's (1980. Transitivity in grammar and discourse.Language56(2). 251–299) parameters of transitivity. In a corpus of 7,939 clauses from 23 oral interviews, 690 randomly sampled clause units were analyzed using Generalized Estimating Equation. The data suggests that, in Brazilian Portuguese, most of those parameters are not particularly related to the prototypical transitive syntax and might be specified outside the scope of this clausal structure. Nonetheless, Affectedness is a syntax/semantic interface point that is, first, largely independent of lexical items and, second, capable of distinguishing transitive syntax from other clausal patterns. Based on this analysis, we conceive the Transitive Construction as a superordinate rule that acts upon the formal organization of a language, establishing clausal patterns both synchronically and diachronically.
An abstract formulation of a theorem of Sierpiński on the nonmeasurable sum of two measure zero sets
Authors: Basu Sanjib , Sen Debasish
Published: November 2019

Here we give an abstract formulation (in uncountable commutative groups) of a classical theorem of Sierpiński on the nonmeasurability of the algebraic sum of measure zero sets.