bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategies and tools to aid the transition between paediatric and adult health services for young adults with neurodevelopmental disorders: a scoping review protocol
Authors: Thanalingam Yattheesh , Langridge Fiona , Gordon Iris , Russell Jin , Muir Colette , Hamm Lisa Marie
Published: November 2022

Introduction

The transition from paediatric to adult healthcare comes with risk and vulnerability for young adults with neurodevelopmental disorders and their carers. Deficits in health, social and disability systems and the fragmentation of services exacerbate problems during the transition period, leaving young people and their carers feeling disconnected with existing services. With advances in healthcare, the number of young adults with neurodevelopmental disorders requiring transition services is increasing. This scoping review aims to summarise the strategies and tools that help ease the transition to adult services for young adults with neurodevelopmental disorders.

Methods and analysis

Systematic searches of MEDLINE, EMBASE and PsychInfo on the OVID platform were performed on 28/05/2022. Studies that describe tools or strategies designed to ease the transition from child-centred to adult-orientated healthcare for young adults with neurodevelopmental disorders will be included. Two authors will independently review titles, abstracts and full-text articles against the inclusion criteria to determine eligibility. Data will be extracted and synthesised using descriptive stats and thematic analysis. The Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews guidelines will be followed.

Conclusion

This scoping review will synthesise the published literature describing strategies and tools to improve the transition of young adults with neurodevelopmental disorders to adult services. The findings of the review may inform areas of future research to improve care for all involved in the transition process.

Ethics and dissemination

This review will include published data; as such, ethics approval is not required. We will publish our findings in an open-access, peer-reviewed journal and summarise the results for dissemination to the wider community of clinicians, allied healthcare professionals, teaching professionals, policymakers, non-governmental organisations, impacted youth and parents.
Study protocol for Video Images about Decisions to Improve Ethical Outcomes with Palliative Care Educators (VIDEO-PCE): a pragmatic stepped wedge cluster randomised trial of older patients admitted to the hospital
Authors: Lakin Joshua R , Zupanc Sophia N , Lindvall Charlotta , Moseley Edward T , Das Sophiya , Sciacca Kate , Cabral Howard J , Burns Edith A , Carney Maria T , Itty Jennifer , Lopez Santiago , Emmert Kaitlin , Martin Narda J , Lambert Sherene , Polo Jennifer , Sanghani Shreya , Dugas Julianne N , Gomez Michele , Winter Michael R , Wang Na , Gabry-Kalikow Shira , Dobie Alexandra , Amshoff Meredith , Cucinotta Traci , Joel Milton , Caruso Lisa B , Ramirez Ana Maria , Salerno Kathleen , Ogunneye Qausarat , Henault Lori , Davis Aretha Delight , Volandes Angelo , Paasche-Orlow Michael K
Published: November 2022

Introduction

Despite the known benefit to patients and families, discussions about goals, values and preferences for medical care in advancing serious illness often do not occur. Many system and clinician factors, such as patient and clinician reticence and shortage of specialty palliative care teams, contribute to this lack of communication. To address this gap, we designed an intervention to promote goals-of-care conversations and palliative care referrals in the hospital setting by using trained palliative care educators and video decision aids. This paper presents the rationale, design and methods for a trial aimed at addressing barriers to goals-of-care conversations for hospitalised adults aged 65 and older and those with Alzheimer’s disease and related Dementias, regardless of age.

Methods and analysis

The Video Image about Decisions to Improve Ethical Outcomes with Palliative Care Educators is a pragmatic stepped wedge, cluster randomised controlled trial, which aims to improve and extend goals-of-care conversations in the hospital setting with palliative care educators trained in serious illness communication and video decision aids. The primary outcome is the proportion of patients with goals-of-care documentation in the electronic health record. We estimate that over 9000 patients will be included.

Ethics and dissemination

The Institutional Review Board (IRB) at Boston Medical Center will serve as the single IRB of record for all regulatory and ethical aspects of this trial. BMC Protocol Number: H-41482. Findings will be presented at national meetings and in publications. This trial is registered at ClinicalTrials.gov.

Trial registration number

NCT04857060
; ClinicalTrials.gov
Pain predict genetics: protocol for a prospective observational study of clinical and genetic factors to predict the development of postoperative pain
Authors: Li Song , van Boekel Regina L M , van den Heuvel Sandra A S , Coenen Marieke J H , Vissers Kris C P
Published: November 2022

Introduction

Postoperative pain remains a challenging medical condition impacting the quality of life of every patient. Although several predictive factors for postoperative pain have been identified, an adequate prediction of postoperative pain in patients at risk has not been achieved yet.

The primary objective of this study is to identify specific genetic risk factors for the development of acute and chronic postoperative pain to construct a prediction model facilitating a more personalised postoperative pain management for each individual. The secondary objectives are to build a databank enabling researchers to identify other risk factors for postoperative pain, for instance, demographic and clinical outcome indicators; provide insight into (genetic) factors that predict pharmacological pain relief; investigate the relationship between acute and chronic postoperative pain.

Methods and analysis

In this prospective, observational study, patients who undergo elective surgery will be recruited to a sample size of approximately 10 000 patients. Postoperative acute and chronic pain outcomes will be collected through questionnaires at different time points after surgery in the follow-up of 6 months. Potential genetic, demographic and clinical risk factors for prediction model construction will be collected through blood, questionnaires and electronic health records, respectively.

Genetic factors associated with acute and/or chronic postoperative pain will be identified using a genome-wide association analysis. Clinical risk factors as stated in the secondary objectives will be assessed by multivariable regression. A clinical easy-to-use prediction model will be created for postoperative pain to allow clinical use for the stratification of patients.

Ethics and dissemination

The Institutional Review Board of the Radboud university medical centre approved the study (authorisation number: 2012/117). The results of this study will be made available through peer-reviewed scientific journals and presentations at relevant conferences, which will finally contribute to personalised postoperative pain management.

Trial registration number

NCT02383342.
Protocol for a collaborative randomised effectiveness trial of lay-delivered versus clinician-delivered behavioural activation in senior centres
Authors: Raue Patrick J , Sirey Jo Anne , Gum Amber , Hawrilenko Matt , Fisher Dylan M
Published: November 2022

Introduction

Depression is common among community-dwelling older adults who make use of senior centre services yet remains undertreated due to a lack of acceptable and available treatments. Emerging evidence suggests that lay health providers can offer psychosocial interventions for mental health disorders experienced by older adults. We developed a streamlined Behavioural Activation intervention (called ‘Do More, Feel Better’; DMFB) to be delivered by older adult volunteers and propose to compare its effectiveness to that of clinician-delivered behavioural activation (BA).

Methods and analysis

This study is a type I collaborative randomised effectiveness trial testing the effect of DMFB in comparison to BA among 288 senior centre clients (aged 60+). Participant clients will be recruited from 6 Seattle, 6 New York City and 6 Tampa area senior centres serving economically and ethnically diverse communities. Primary outcomes will be increased activity level (target) and decreased depressive symptoms. Secondary outcomes will be functioning and client satisfaction, and an exploratory outcome will be treatment fidelity.

Ethics and dissemination

The study received ethics approval from the University of Washington Institutional Review Board (STUDY00011434). Client, volunteer and clinician participants will all provide informed consent for study procedures through in-person or remote contact with investigators. Results of this study will be presented in peer-reviewed journals and at professional conferences.

Trial registration number

NCT04621877; ClinicalTrials.gov.
Prevalence and risk factors of work-related contact dermatitis symptoms among healthcare cleaners during the COVID-19 pandemic in Northwest Ethiopia: a multicentre cross-sectional survey
Authors: Tesfaye Amensisa Hailu , Engdaw Garedew Tadege , Aragaw Fantu Mamo , Kabito Gebisa Guyasa
Published: November 2022

Objective

This study was aimed to explore the prevalence and risk factors of work-related contact dermatitis (WRCD) symptoms among cleaners working in healthcare institutions in Gondar city, Northwest Ethiopia, during the COVID-19 pandemic.

Design

A multicentre cross-sectional study was conducted from September to October 2021. An interviewer-administered standardised Nordic Occupational Skin Questionnaire, V.2002 (NOSQ-2002) was used to assess WRCD. The collected data were entered into EpiData V.4.6 and analysed using Stata V.14 software. The association between dependent and independent variables was computed with a binary logistic regression. The association was determined using an adjusted OR (AOR) with a 95% CI at a p value of <0.05.

Setting

The study was conducted in Gondar city healthcare institutions, Northwestern Ethiopia.

Participants

A total of 409 cleaners participated in this study.

Outcome measures

The primary outcome is the prevalence of WRCD symptoms, which was measured using the NOSQ-2002.

Results

The response rate was 95.6%. The majority, 302 (73.8%), of the study participants were female. The mean age (±SD) was 31 (±7.87) years old. The overall prevalence of self-reported WRCD during the last 12 months was 213 (52.1%) (95% CI (47.1% to 57.0%)). The highest symptoms reported were skin redness, 51.6% (n=110), and the most affected skin body sites were hands (hand dermatitis), 74.2% (n=158). Hand washing frequency more than 20 times per day (AOR=1.73, 95% CI (1.03 to 2.92)), personal history of eczema (AOR=1.46, 95% CI (1.01 to 2.42)) and lack of training on skin hazards (AOR=2.06, 95% CI (1.16 to 3.63)) were factors influencing the occurrence of WRCD.

Conclusions

This study revealed the prevalence of WRCD is common during the COVID-19 pandemic. Adjusting hand washing frequency per day, educating people with atopy about the avoidance of exposure to skin irritants and providing training on skin hazards were recommended to minimise the condition.
The Fusion-by-Diffusion model as a tool to calculate cross sections for the production of superheavy nuclei
Authors: Cap T. , Kowal M. , Siwek-Wilczyńska K.
Published: November 2022

This article summarizes recent progress in our understanding of the reaction mechanisms leading to the formation of superheavy nuclei in cold and hot fusion reactions. Calculations are done within the Fusion-by-Diffusion (FBD) model using the new nuclear data tables by Jachimowicz et al. (At Data Nucl Data Tables 138, 101393, 2021). The synthesis reaction is treated in a standard way as a three-step process (i.e., capture, fusion, and survival). Each reaction step is analysed separately. Model calculations are compared with selected experimental data on capture, fissionlike and fusion cross sections, fusion probabilities, and evaporation residue excitation functions. The role of the angular momentum in the fusion step is discussed in detail. A set of fusion excitation functions with corresponding fusion probabilities is provided for cold and hot synthesis reactions.
Population transfer under local dephasing
Authors: Huang Wei , Zhang Wentao , Du Xinwei , Guo Chu
Published: November 2022

Stimulated Raman adiabatic passage is a well-known technique for quantum population transfer due to its robustness again various sources of noises. Here we consider quantum population transfer from one spin to another via an intermediate spin which is under dephasing noise. We obtain an analytic expression for the transfer efficiency under a specific driving protocol, showing that dephasing could reduce the transfer efficiency, but the effect of dephasing could also be suppressed with a stronger laser coupling or a longer laser duration. We also consider another commonly used driving protocol, which shows that this analytic picture is still qualitatively correct.
Quantum algorithm for calculating risk contributions in a credit portfolio
Authors: Miyamoto Koichi
Published: November 2022

Finance is one of the promising field for industrial application of quantum computing. In particular, quantum algorithms for calculation of risk measures such as the value at risk and the conditional value at risk of a credit portfolio have been proposed. In this paper, we focus on another problem in credit risk management, calculation of risk contributions, which quantify the concentration of the risk on subgroups in the portfolio. Based on the recent quantum algorithm for simultaneous estimation of multiple expected values, we propose the method for credit risk contribution calculation. We also evaluate the query complexity of the proposed method and see that it scales as$\widetilde{O} (\sqrt{N_{\mathrm{gr}}}/\epsilon )$O˜(Ngr/ϵ)on the subgroup number$N_{\mathrm{gr}}$Ngrand the accuracyϵ, in contrast with the classical method with$\widetilde{O} (\log(N_{\mathrm{gr}})/\epsilon^{2} )$O˜(log(Ngr)/ϵ2)complexity. This means that, for calculation of risk contributions of finely divided subgroups, the advantage of the quantum method is reduced compared with risk measure calculation for the entire portfolio. Nevertheless, the quantum method can be advantageous in high-accuracy calculation, and in fact yield less complexity than the classical method in some practically plausible setting.
The expanded Maxwell’s equations for a mechano-driven media system that moves with acceleration
Authors: Wang Zhong Lin
Published: November 2022

In classical electrodynamics, by motion for either the observer or the media, it is always naturally assumed that the relative moving velocity is a constant along a straight line (e.g., in inertia reference frame), so that the electromagnetic behavior of charged particles in vacuum space can be easily described using special relativity. However, for engineering applications, the media have shapes and sizes and may move with acceleration, and recent experimental progresses in triboelectric nanogenerators have revealed evidences for expanding Maxwell’s equations to include media motion that could be time and even space dependent. Therefore, we have developed the expanded Maxwell’s equations for a mechano-driven media system (MEs-f-MDMS) by neglecting relativistic effect. This paper first presents the updated progresses made in the field. Second, we extensively investigated Faraday’s law of electromagnetic induction for a media system that moves with an acceleration. We concluded that the newly developed MEs-f-MDMS are required for describing the electrodynamics inside a media that has a finite size and volume and move with and even without acceleration. The classical Maxwell’s equations are to describe the electrodynamics in vacuum space when the media in the nearby move.
Big data approaches to knot theory: Understanding the structure of the Jones polynomial
Authors: Levitt Jesse S. F. , Hajij Mustafa , Sazdanovic Radmila
Published: November 2022

In this paper, we examine the properties of the Jones polynomial using dimensionality reduction learning techniques combined with ideas from topological data analysis. Our data set consists of more than 10 million knots up to 17 crossings and two other special families up to 2001 crossings. We introduce and describe a method for using filtrations to analyze infinite data sets where representative sampling is impossible or impractical, an essential requirement for working with knots and the data from knot invariants. In particular, this method provides a new approach for analyzing knot invariants using Principal Component Analysis. Using this approach on the Jones polynomial data, we find that it can be viewed as an approximately three-dimensional subspace, that this description is surprisingly stable with respect to the filtration by the crossing number, and that the results suggest further structures to be examined and understood.
Evidence, or not, for the late Tonian break-up of Rodinia? The Dalradian Supergroup, Scotland
Authors: Prave A. R. , Fallick A. E. , Kirsimäe K.
Published: November 2022

The Tonian–Cambrian Dalradian Supergroup in Scotland is a siliciclastic–carbonate succession that can be up to 10 km thick. The consensus view is that its lower part, the mid- to late Tonian Grampian and Appin groups, formed in rift basins: the deep marine turbidites of the Grampian Group infilled rift depocentres, whereas the shallow marine strata of the Appin Group mark basin-bounding palaeohighs. This scenario is used as a key line of evidence to infer the onset of the break-up of Rodinia between Laurentia and Baltica. However, deformation during the mid-Ordovician Caledonian Orogeny obscured the original depositional frameworks. Reconstructing these frameworks (and hypothesized rift basins) has relied on the trace and major element log-ratio geochemistry of minor carbonate rocks to assign the units to either the Grampian or Appin group – that is, to rift depocentres or basin-bounding palaeohighs, respectively. We report new carbon and oxygen isotope and geochemical data and use these to create a revised stratigraphic framework for the Grampian and Appin groups. Our findings show that the previous geochemical-based correlations are unreliable and that there is no evidence for palaeohighs or rift basins. Instead, the Grampian–Appin groups are a deeper marine flysch to a shallower marine molasse succession formed in response to the mid-Tonian Knoydartian Orogeny. From a Scottish perspective, evidence for the break-up of Rodinia is recorded higher in the Dalradian succession during the deposition of the early Cryogenian Argyll Group.

Supplementary material:
Geochemical analysis of samples is available at
https://doi.org/10.6084/m9.figshare.c.6317830

Thematic collection:
This article is part of the Caledonian Wilson cycle collection available at:
https://www.lyellcollection.org/topic/collections/the-caledonian-wilson-cycle
ACTION: Adaptive Cache Block Migration in Distributed Cache Architectures
Authors: Mummidi Chandra Sekhar , Kundu Sandip
Published: November 2022

Chip multiprocessors (CMP)
with more cores have more traffic to the
last-level cache (LLC)
. Without a corresponding increase in LLC bandwidth, such traffic cannot be sustained, resulting in performance degradation. Previous research focused on data placement techniques to improve access latency in
Non-Uniform Cache Architectures (NUCA)
. Placing data closer to the referring core reduces traffic in cache interconnect. However, earlier data placement work did not account for the frequency with which specific memory references are accessed. The difficulty of tracking access frequency for all memory references is one of the main reasons why it was not considered in NUCA data placement.

In this research, we present a hardware-assisted solution called

ACTION (
A
daptive
C
ache Block Migra
tion
)

to track the access frequency of individual memory references and prioritize placement of frequently referred data closer to the affine core. ACTION mechanism implements cache block migration when there is a detectable change in access frequencies due to a shift in the program phase. ACTION counts access references in the LLC stream using a simple and approximate method and uses a straightforward placement and migration solution to keep the hardware overhead low. We evaluate ACTION on a 4-core CMP with a 5x5 mesh LLC network implementing a partitioned D-NUCA against workloads exhibiting distinct asymmetry in cache block access frequency. Our simulation results indicate that ACTION can improve CMP performance by up to 7.5% over
state-of-the-art (SOTA)
D-NUCA solutions.
Development of a Novel Nomogram Incorporating Red Blood Cell Distribution Width-Albumin Ratio for the Prediction of 30-day Mortality in Acute Pancreatitis Patients
Authors: Pan Li-na , Pan Shen-ao , Lei Bu-huai , Hong Guang-liang , Chen Kun-wei
Published: November 2022

Purpose. The available nomograms used to predict acute pancreatitis (AP) are not comprehensive. We sought to investigate the effect of red blood cell distribution width (RDW)-albumin ratio (RA) on prognosis of patients with AP and develop a new nomogram to identify AP patients at high risk for mortality. Methods. We used data from the Medical Information Mart for Intensive Care IV version 2.0 (MIMIC-IV v2.0). A total of 487 patients with acute pancreatitis were included. Patients enrolled in the study were randomly assigned to the training set and validation set at a 7 : 3 ratio. According to the 30-day mortality rate, the data were divided into a survival group and a death group. Multivariate logistic regression was used to establish a prognostic nomogram for predicting the 30-day mortality in AP patients. The area under the receiver operating characteristic curve (AUC), calibration curve, the net reclassification improvement (NRI), the integrated discrimination improvement (IDI), and a decision curve analysis (DCA) are used to verify the overall performance of the model. Results. Among 487 patients, 54 patients died (11.1%). 338 patients were assigned to the training cohort and 149 were assigned to the validation cohort. The multivariate analysis results showed that RA, age, heart rate, temperature, AST/ALT, BUN, hemoglobin, potassium, and bilirubin were independent risk factors. The prediction performance of the newly established nomogram was better than those of other common scoring systems (including SOFA, OASIS, and APSIII). The nomogram suggests that RA (OR = 1.706, 95% CI: 1.367–2.185) is the most significant laboratory test indicator influencing prognosis. Conclusion. The new nomogram incorporating RA performed well in predicting AP short-term mortality. A prospective study with a larger sample is needed to validate our findings.
A Qualitative Study to Explore the Determinants of Risky Sexual Behaviors and Pregnancy among Female Adolescents in Sabah, Malaysia
Authors: Idris Idayu Badilla , Bin Sulaiman Shameer Khan , Hod Rozita , Khazaei Hamed , Abdullah Nik Nairan
Published: November 2022

This investigation was performed in Kota Kinabalu, Sabah state, where the highest number of pregnancies is recorded. The purpose of this study was to determine variables associated with hazardous sexual activity and adolescent pregnancy in Sabah, Malaysia. The findings indicate that familial variables, peer interactions, self-esteem, psychiatric concerns, economic considerations, and sex knowledge all play a significant role in hazardous sexual conduct and adolescent pregnancy in Sabah, Malaysia. Information obtained from this study will help the Malaysian government and other officials to design and establish proper interventions that will help alleviate the challenge of high prevalence of teenage pregnancy. It is suggested that sex education be included in the high school curriculum, along with physical and health education in Sabah, Malaysia.
Production and Evaluation of Quality Characteristics of Edible Fish Powder from Tilapia (Oreochromis mossambicus) and Silver Carp (Hypophthalmichthys molitrix)
Authors: Kabir Md. Iftekhar , Ove Towkir Ahmed , Kamal Md. Murtuza , Karim Safayetul , Hasan S. M. Kamrul , Haque Md. Raihanul , Akhter Most. Jesmin
Published: November 2022

Fish is recognised as the most nutritious animal protein source, but because of its high deterioration nature, a huge number of fish are being wasted and susceptible to nutritional losses, resulting in a significant hurdle for expanding fish production. This research aimed to lessen these losses through the use of fish powder and to enhance the nutrients in people’s diets. In order to prepare fine fish powder, a dried fish paste was milled and sieved. Proximate analysis, mineral content, and physical and microbiological qualities were determined using standard analytical procedures. The protein content of Tilapia and Silver Carp fish powder was 63.63 g/100 g and 73.58 g/100 g, respectively. An appreciable amount of potassium, calcium, magnesium, phosphorus, iron, and zinc was also found in Tilapia and Silver Carp fish powder. The powder also holds an angle of repose of 29.4° and 26.7°, which assures a good flow property. Both Tilapia and Silver Carp fish powder have shown a near neutral pH value (6.40 and 6.32). The hedonic rating scale was used to assess the acceptability of fish powder-fortified cakes. The results showed that the cake fortified with Silver Carp fish powder outperforms the control and Tilapia fish powder sample in terms of taste, flavour, colour, texture, and overall acceptance, while the panellists also preferred the Tilapia fish powder sample. As a result of this research, a high-quality nutritious fish powder from Tilapia and Silver Carp can be prepared and adopted as a food fortifier.
A Data-Driven Fault Prediction Method for Nuclear Power Systems Based on End-to-End Deep Learning Framework
Authors: Chao Lu , Wang Chunbing , Chen Shuai , Duan Qizhi , Xie Hongyun
Published: November 2022

With the increase in system complexity and operational performance requirements, nuclear energy systems are developing in the direction of intelligence and unmanned, which also requires a higher demand for its safety so that intelligent fault diagnosis and prediction have become a technology that nuclear power plants need to develop at present. At the same time, due to the rapid development of deep learning technology, it has become a meaningful development direction to predict the fault state of nuclear power plants within the framework of supervised deep learning. Usually, the network structure model used in fault diagnosis and prediction requires professional design, which may cost a lot of time and make it difficult to achieve optimal results. For this purpose, we present an end-to-end deep network for nuclear power system prediction (EDN-NPSP), which can automatically mine the transient features of various detection data in the NPS at the current moment through heterogeneous convolution kernels that can increase the receptive field and then predict the feature evolution results of the NPS in the future through a special deep CNN. The results provide an assessment of the future state of NPS. Based on EDN-NPSP presented in this work, we can avoid complicated manual feature extraction and provide the predicted state directly and rapidly. It will provide operators with useful prediction information and enhance the nuclear energy system fault prediction capabilities.
Upregulation of Glutaminyl Cyclase Contributes to ERS‐Induced Apoptosis in PC12 Cells
Authors: Shang Qi , Yu Xi , Ouyang Na , Xu Pan , Chen Xiaojie , Wang Yinan , Li Chenyang , Wang Xiaojuan , Lu Xifeng , Xu Chenshu , Wu Haiqiang
Published: November 2022

Glutaminyl cyclase (QC) is responsible for converting the N‐terminal glutaminyl and glutamyl of the proteins into pyroglutamate (pE) through cyclization. It has been confirmed that QC catalyzes the formation of neurotoxic pE‐modified Aβ in the brain of AD patients. But the effects of upregulated QC in diverse diseases have not been much clear until recently. Here, RNA sequencing was applied to identify differentially expressed genes (DEGs) in PC12 cells with QC overexpressing or knockdown. A total of 697 DEGs were identified in QC overexpressing cells while only 77 in QC knockdown cells. Multiple bioinformatic approaches revealed that the DEGs in QC overexpressing group were enriched in endoplasmic reticulum stress (ERS) related signaling pathways. The gene expression patterns of 23 DEGs were confirmed by RT‐qPCR, in which the genes related to ERS showed the highest consistency. We also revealed the protein levels of GRP78, PERK, CHOP, and PARP‐1, and caspase family was significantly upregulated by overexpressing QC. Moreover, overexpressing QC significantly increased apoptosis of PC12 cells in a time dependent manner. However, no significant alteration was observed in QC knockdown cells. Therefore, our study indicated that upregulated QC could induce ERS and apoptosis, which consequently trigger diseases by catalyzing the generation of pE‐modified mediators.
Optimal Coordination of TCSC and PSS2B Controllers in Electric Power Systems Using MOPSO Multiobjective Algorithm
Authors: Ahmadi Kamarposhti Mehrdad , Shokouhandeh Hassan , Gholami Omali Yahya , Colak Ilhami , Thounthong Phatiphat , Holderbaum William
Published: November 2022

Oscillations are an intrinsic phenomenon in interconnected power systems, leading to steady-state stability, safety decline, transmission power limitation, and electric power systems’ ineffective exploitation by developing power systems, particularly by connecting these systems to low-load lines. In addition, they affect the economic performance of the systems. In this study, PSS2B power system stabilizers and TCSC compensators are used to improve the stability margin of power systems. In order to coordinate TCSC compensators, the MOPSO multiobjective algorithm with integral of the time-weighted absolute error (ITAE) and figure of demerit (FD) objective functions was used. The MOPSO algorithm optimization results are compared with nondominated sorting genetic algorithm (NSGAII) and multiobjective differential evolution (MODE) algorithms. The optimization results indicated a better performance of the proposed MOPSO algorithm than NSGAII and MODE. The simulations were iterated in two scenarios by creating different loading conditions in generators. The results indicated that the proposed control system, where the coordination between PSS2B power system stabilizers and TCSC compensators using the MOPSO algorithm, is better than power systems in which PSS2B Stabilizers or TCSC compensators are utilized solely. All criteria, e.g., ITAE, FD, maximum deviation range, and the required time for power oscillation damping in hybrid control systems, have been obtained. This means more stability and accurate and proper performance.
Dexamethasone Coanalgesic Administration in Steroid Naïve and Steroid Non-Naïve Patients for the Prevention of Pain Flares after Palliative Radiotherapy for Bone Metastases
Authors: Tonev Dimitar G. , Lalova Silvia A. , Petkova-Lungova Elena P. , Timenov Nikolay V. , Radeva Gabriela M. , Kundurzhiev Todor G.
Published: November 2022

Objective. Dexamethasone could be an effective prophylactic agent for the prevention of pain flares after palliative radiotherapy (RT) for uncomplicated bone metastases. To date, there are no data on its prophylactic coanalgesic (opioid-sparing) effect after RT in patients with complicated bone metastases compared to uncomplicated ones, which is the aim of our study. Methods. Twenty-nine American Society of Anaesthesiologists (ASA) III-IV patients, aged ≥18, treated with single-fraction 8 Gy/1 or multi-fraction 20 Gy/5 RT for painful uncomplicated bone metastases (steroid naïve patients, n = 14) or complicated ones (steroid non-naïve patients, n = 15), were examined retrospectively. All patients received parenteral dexamethasone (4 mg or 8 mg daily, 1 hour before RT, followed by the same dose for the next 4 days) along with their background and breakthrough pain opioid intake (morphine equivalents) during their 5-day in-hospital stay. Pain severity (numeric rating scale) and analgesic consumption were recorded at admission, daily during the hospital stay, and for 10 days following treatment. Binary logistic regression was used to determine predictive factors for pain flare occurrence. Results. A higher ASA score is the only determinant positively influencing opioid consumption (

P

 = 0.018) and pain flare as well (OR = 15.00; 95% CI: 2, 24–100, 48;

P

 = 0.005). Lower dose 4 mg dexamethasone was revealed as a moderate analgesic agent in steroid naïve patients with no side effects, whereas in steroid non-naïve patients the predominantly higher dose 8 mg dexamethasone had minimal impact on pain flares prevention at the expense of more pronounced immunosuppression (

P

 = 0.039). Conclusions. Irrespective of the supporting evidence of dexamethasone potential for prevention of RT-induced pain flare, our data failed to reveal its efficacy in the real practice world (a case mix of uncomplicated and complicated bone metastases). Further dose-effect bigger studies are needed, identifying optimal doses of dexamethasone intake and its optimal duration in high-risk patients.
RBM10 Is a Biomarker Associated with Pan-Cancer Prognosis and Immune Infiltration: System Analysis Combined with In Vitro and Vivo Experiments
Authors: Cao Yingyue , Pang Luyi , Jin Shi
Published: November 2022

RNA binding motif protein 10 (RBM10) is a splicing factor that has been reported to be involved in the occurrence and progression of multiple malignancies. However, the RBM10 involvement in pan-cancer immunotherapy is not clear. In here, we provide the first comprehensive assessment of the prognostic value and immunological function of RBM10 in human pan-cancer utilizing multiple public databases. Data reveal the aberrant RBM10 expression in most tumors, and its expression is positively or negatively linked with the clinical prognosis of various cancers, depending on the different types and subtypes of cancers. In most tumors, RBM10 mutations are frequently occurred, which is closely related to tumor progression. Moreover, our results also show that RBM10 is considerably linked with most of the immune checkpoint genes, tumor immune cell infiltration, tumor mutation burden, and microsatellite instability. Additionally, RBM10 is significantly positively correlated with the sensitivity of trametinib, 17-AAG, PD-0325901, RDEA119, cetuximab, and afatinib, indicating potential antagonism between RBM10 inhibitors and these antitumor drugs, and more likely to develop drug resistance. We also verify that downregulation of RBM10 enhances the malignant phenotype of lung adenocarcinoma cells using in vitro cell experiments, and in vivo animal experiments show that the overexpression of RBM10 reduces the growth of tumors. Furthermore, upregulating RBM10 greatly reduces the PD-L1 protein levels, while silencing RBM10 considerably enhances PD-L1 protein levels. Moreover, the overexpression of RBM10 decreases the protein stability of PD-L1. To sum up, our pan-cancer analysis indicates that RBM10 is a promising biomarker for prognosis and immunotherapy, which provides a new insight for cancer immunotherapy.
Prevalence of Bovine Schistosomiasis and Associated Risk Factors in Tis Abay District, Northwest Ethiopia
Authors: Kifle Temesgen , Bayile Tirumengist , Fesseha Haben , Mathewos Mesfin
Published: November 2022

Background. Schistosomiasis is a parasitic disease of cattle that is caused by trematode worms and results in morbidity, mortality, reduced fertility, and productivity. Methods. A cross-sectional study was conducted to determine the prevalence and associated risk factors for bovine schistosomiasis in Tis Abay district, Amhara, Ethiopia. Fecal samples were collected from 384 randomly selected cattle and examined using the sedimentation technique. Results. Of the total examined fecal samples, 13.02% (50/384) of the samples were positive for Schistosoma bovis eggs. The prevalence of schistosomiasis was highly reported in Dasra (22.4%), which was statistically significant (

p
≤
0.001

). The prevalence of bovine schistosomiasis was higher in females (16.9%), crossbred cattle (17.1%), poorly conditioned cattle (37.1%), extensively managed cattle (17.9%), and cattle greater than 5 years old (23.1%). The multivariate analysis of factors revealed that study area, age, breed, body condition, and management system have a significant role (

p
<
0.05

) in the prevalence of bovine schistosomiasis. Conclusion. Schistosoma infection is a problem for cattle in the study region. Therefore, farmers should be aware of the transmission of the disease, prevention, and control of snails.
LZTR1Mutation Mediates Oncogenesis through Stabilization of EGFR and AXL
Authors: Ko Aram , Hasanain Mohammad , Oh Young Taek , D'Angelo Fulvio , Sommer Danika , Frangaj Brulinda , Tran Suzanne , Bielle Franck , Pollo Bianca , Paterra Rosina , Mokhtari Karima , Soni Rajesh Kumar , Peyre Matthieu , Eoli Marica , Papi Laura , Kalamarides Michel , Sanson Marc , Iavarone Antonio , Lasorella Anna
Published: November 2022

LZTR1 is the substrate-specific adaptor of a CUL3-dependent ubiquitin ligase frequently mutated in sporadic and syndromic cancer. We combined biochemical and genetic studies to identify LZTR1 substrates and interrogated their tumor-driving function in the context of LZTR1 loss-of-function mutations. Unbiased screens converged on EGFR and AXL receptor tyrosine kinases as LZTR1 interactors targeted for ubiquitin-dependent degradation in the lysosome. Pathogenic cancer-associated mutations of LZTR1 failed to promote EGFR and AXL degradation, resulting in dysregulated growth factor signaling. Conditional inactivation of Lztr1 and Cdkn2a in the mouse nervous system caused tumors in the peripheral nervous system including schwannoma-like tumors, thus recapitulating aspects of schwannomatosis, the prototype tumor predisposition syndrome sustained by LZTR1 germline mutations. Lztr1– and Cdkn2a-deleted tumors aberrantly accumulated EGFR and AXL and exhibited specific vulnerability to EGFR and AXL coinhibition. These findings explain tumorigenesis by LZTR1 inactivation and offer therapeutic opportunities to patients with LZTR1-mutant cancer.

Significance:

EGFR and AXL are substrates of LZTR1-CUL3 ubiquitin ligase. The frequent somatic and germline mutations of LZTR1 in human cancer cause EGFR and AXL accumulation and deregulated signaling. LZTR1-mutant tumors show vulnerability to concurrent inhibition of EGFR and AXL, thus providing precision targeting to patients affected by LZTR1-mutant cancer.

This article is highlighted in the In This Issue feature, p. 517
Cetuximab-Induced Aseptic Meningitis in a Patient with Colorectal Cancer: A Case Report and Review of Literature
Authors: Jäger Jakob , Sprügel Maximilian , Brunner Tamara , Uhl Martin , Schwab Stefan , Vitali Francesco , Wein Axel , Volbers Bastian
Published: November 2022

Cetuximab is a chimeric IgG1 monoclonal antibody against epidermal growth factor receptor. It is approved by the European medical agency for the treatment of RAS wild-type metastatic colorectal cancer and metastatic squamous cell cancer of the head and neck. Few cases of aseptic meningitis, primarily associated with the first administration of cetuximab in patients with squamous cell cancer, have been reported. So far, there was only 1 case in a patient with metastatic colorectal cancer. We report on a 50-year-old Caucasian patient with metastatic rectum carcinoma who suffered from headache, fever, and neck stiffness 3 h after the first administration of cetuximab (400 mg/m2). CSF examination revealed an excessive pleocytosis with a white blood cell count of 2,433/µL. He was diagnosed with cetuximab-induced aseptic meningitis since clinical symptoms and CSF pleocytosis resolved within days, and further diagnostic workup revealed no infectious cause. Cetuximab-induced aseptic meningitis is a rare and severe drug reaction with predominance in treating squamous cell cancer of the head and neck. Clinical presentation and CSF findings suggest acute meningoencephalitis. In all reported cases, the course of the disease was benign and self-limited. Empiric antimicrobial and antiviral therapy are suggested until infectious causes can be ruled out. A lower dosage of cetuximab and a premedication including antihistamines and glucocorticosteroids may lower the risk of a re-occurrence if cetuximab therapy is continued.
A Case of Full Recovery from Prolonged Cardiac Arrest after Infusion with Paclitaxel and Pembrolizumab
Authors: Sh Ahmed Omar , Mahadevia Himil , Manochakian Rami , Zhao Yujie , Salinas Manisha , Khoor Andras , LeGout Jordan , Lou Yanyan
Published: November 2022

Lung cancer is one of the most common cancers and has the highest risk of mortality in both genders. This devastating cancer is also a significant financial and emotional burden to patients and the healthcare system. Chemotherapy and immunotherapy have become the cornerstone for the treatment of lung cancer. However, treatment may come with severe and sometimes fatal side effects. In this report, we present the case of a 52-year-old Caucasian male who suffered two episodes of prolonged cardiac arrest after the infusion of paclitaxel and pembrolizumab.
A Simple Grading Scale for Predicting Symptomatic Intracranial Hemorrhage after Mechanical Thrombectomy
Authors: Lei Chunyan , Li Yongyu , Zhou Xianlian , Lin Shihan , Zhu Xiaoyan , Yang Xinglong , Chen Chun
Published: November 2022

Introduction: Hemorrhagic transformation, especially symptomatic intracranial hemorrhage (sICH), is a common complication after mechanical embolectomy. This study explored a grading scale based on clinical and radiological parameters to predict sICH after mechanical embolectomy. Methods: Demographic and clinical data were retrospectively collected from patients with acute ischemic stroke treated with mechanical embolectomy at West China Hospital. Clinical and radiological factors associated with sICH were identified and used to develop the “STBA” grading scale. This score was then validated using data from an independent sample at the First Affiliated Hospital of Kunming Medical University. Results: We analyzed 268 patients with acute ischemic stroke who were treated with mechanical embolectomy at West China Hospital, of whom 30 (11.2%) had sICH. Patients were rated on an “STBA” score ranging from 0 to 6 based on whether systolic blood pressure was ≥145 mm Hg at admission (yes = 2 points; no = 0 points), time from acute ischemic stroke until groin puncture was ≥300 min (yes = 1; no = 0), blood glucose was ≥8.8 mmol/L (yes = 1; no = 0), and the Alberta Stroke Program Early Computed Tomography score at admission was 0–5 (2 points), 6–7 (1 point), or 8–10 (0 points). The STBA score showed good discrimination in the derivation sample (area under the receiver operating characteristic curve = 0.858) and in the validation sample (area = 0.814). Conclusions: The STBA score may be a reliable clinical scoring system to predict sICH in acute ischemic stroke patients treated with mechanical embolectomy.
Central Serous Chorioretinopathy Associated with Tadalafil
Authors: Alsarhani Abdulaziz , Alarfaj Motazz , Alhoutan Khalid , Alsubaie Hamad
Published: November 2022

We report a case of central serous chorioretinopathy (CSCR) associated with tadalafil, a phosphodiesterase 5 inhibitor medication. In this report, we describe a case of a 59-year-old male who presented with blurred vision in the right eye. On examination, he was noted to have serous macular, pigment epithelial detachments, and increased choroidal thickness. The diagnosis of CSCR was made, and the patient was asked to stop the offending agent. Three months after stopping tadalafil, the patient’s visual symptoms and subretinal fluid resolved. In conclusion, prescribing physicians should be aware of tadalafil’s ability to decrease vision and cause CSCR. The addition of CSCR to the list of tadalafil’s side effects should also be considered.
Total Fluid Administration and Weight Loss during the First 2 Weeks in Infants Randomized to Early Enteral Feeding after Extremely Preterm Birth
Authors: Durham Leandra , Gunawan Emily , Nguyen Kelly , Reeves Audrey , Shukla Vivek , Salas Ariel A.
Published: November 2022

Background: Randomized trials have not reported the effects of the early progression of feeding volumes on fluid balance and neurodevelopment among infants born extremely preterm (≤28 weeks). Method: Fluid, electrolyte, and neurodevelopment data of 60 extremely preterm infants randomly assigned to receive either 1 (early feeding group) or 4 days (late feeding group) of trophic feeding volumes at 20–24 mL/kg/day were analyzed. Results: Infants randomized to the early feeding group received less parenteral fluids, generated lower urine volumes, and had less excessive weight loss during the first 14 days after birth. The 7-point difference in cognitive scores and the 0.5 difference in weight-for-age z-scores favoring the early feeding group did not reach statistical significance. Conclusions: In extremely preterm infants, early enteral feeding is associated with less total fluid administration and with less excessive weight loss during the first 2 weeks after birth. These short-term effects could have long-lasting benefits.
Needs and Demands for e-Mental Health Interventions in Individuals with Overweight and Obesity: User-Centred Design Approach
Authors: Geiger Sheila , Steinbach Jasmin , Skoda Eva-Maria , Jahre Lisa , Rentrop Vanessa , Kocol Dilara , Jansen Christoph , Schüren Lynik , Niedergethmann Marco , Teufel Martin , Bäuerle Alexander
Published: November 2022

Introduction: Several studies indicate an association between mental disorders and overweight or obesity. E-Mental health interventions offer an effective way to overcome barriers to health care access for individuals with overweight and obesity. The objective of this study was to examine the needs and demands for e-mental health interventions among individuals with overweight and obesity. Methods: A cross-sectional study was conducted from 2020 to 2021 in Germany. A total of 643 participants were recruited through specialized social media platforms and the Alfried-Krupp hospital in Essen, Germany. Sociodemographic and medical data were analysed, as well as data on depressive symptoms and on the needs and demands for e-mental health interventions. Results: Contact with and recommendation by experts appear to be key aspects in the acceptance and use of e-mental health interventions. In summary, most participants preferred a 20–30-min weekly session via smartphone over a 4-month period. The highest preference in terms of features included practicing coping skills and being provided with information; in regard to desired topics, nutrition consultation, quality of life, and adapting to new life situations were considered most important. Discussion: e-Mental health interventions can be highly beneficial for individuals, especially when developed through a user-centred design approach. The results of the study indicate which content and design are preferred and, thereby, provide valuable information for consideration when developing a tailored e-mental health intervention.