bluuebunny/crossref_metadata_2025 huggingface dataset:
Determining Front-Line Therapeutic Strategy for Metastatic Clear Cell Renal Cell Carcinoma
Authors: Zarrabi Kevin K. , Lanade Oladimeji , Geynisman Daniel M.
Published: September 2022

The therapeutic landscape for metastatic renal cell carcinoma has rapidly evolved over the years, and we are now in an era of combination therapy strategies employing immune checkpoint blockade and anti-angiogenesis targeted therapy. Since 2018, we have gained regulatory approval for four distinct combination therapies, all with survival benefits, and with guideline recommendation for use in the front-line setting. As such, treatment selection has become increasingly complex with a myriad of treatment choices but little high-level head-to-head data to guide treatment selection. Heterogeneity in tumor biology further complicates treatment selection as tumors vary in behavior and treatment responsiveness. Ongoing development of biomarkers will certainly assist in this setting, and validation of predictive markers represents an unmet need. In their absence, we highlight features of disease and nuances to datasets from landmark prospective clinical trials to help inform treatment selection. There is growing evidence to support deferring upfront systemic therapy in some patients, with opportunities for active surveillance or metastasis-directed therapy. In others, upfront systemic therapy is warranted and necessitates thoughtful consideration of multiple clinicopathologic parameters to inform optimal patient-centered decision making.
Effectiveness of Resective Surgery in Complex Ameloblastoma of the Jaws: A Retrospective Multicenter Observational Study
Authors: Sozzi Davide , Cassoni Andrea , De Ponti Elena , Moretti Mattia , Pucci Resi , Spadoni Davide , Canzi Gabriele , Novelli Giorgio , Valentini Valentino
Published: September 2022

Ameloblastoma is a rare, benign, odontogenic tumor of epithelial origin, characterized by locally aggressive, expansive growth. Treatment is controversial due to the risk of relapse. The aim of this multicenter retrospective study was to evaluate the effectiveness of complete resection in cases of complex ameloblastoma, which is considered at a higher risk of recurrence. Patients who met at least one of these criteria were included: recurrence, soft-tissue involvement, complete erosion of internal/external cortical walls with involvement of the inferior margin of the mandible, and invasion of the maxillary sinus or nasal cavity. Demographic data, tumor site, type of surgery, histological features, and follow-up information were collected for each patient. The cohort included 55 patients with a mean follow-up of 108 ± 66 months. A multivariate logistic model was used to evaluate variables independently associated with relapse. There were six soft-tissue or maxillary sinus relapses, with a recurrence rate of 10.9%. Most of them arose in patients previously treated. The statistical analysis identified the maxillary location as a fundamental relapse risk factor. En bloc resection with large surgical safety margins seemed to be effective in preventing the relapses. However, complete resection was less effective in preventing recurrences in the soft tissues or maxillary sinus.
Adrenal Insufficiency with Anticancer Tyrosine Kinase Inhibitors Targeting Vascular Endothelial Growth Factor Receptor: Analysis of the FDA Adverse Event Reporting System
Authors: Raschi Emanuel , Fusaroli Michele , Giunchi Valentina , Repaci Andrea , Pelusi Carla , Mollica Veronica , Massari Francesco , Ardizzoni Andrea , Poluzzi Elisabetta , Pagotto Uberto , Di Dalmazi Guido
Published: September 2022

Background: We described clinical features of adrenal insufficiency (AI) reported with tyrosine kinase inhibitors (TKIs) targeting vascular endothelial growth factor receptor (VEGFR) in the Food and Drug Administration Adverse Event Reporting System (FAERS). Methods: Reports of AI recorded in FAERS (January 2004–March 2022) were identified through the high-level term “adrenal cortical hypofunctions”. Demographic and clinical features were inspected, and disproportionality signals were detected through the Reporting Odds Ratio (ROR) and Information Component (IC) with relevant 95% confidence/credibility interval (CI), using different comparators and adjusting the ROR for co-reported corticosteroids and immune checkpoint inhibitors (ICIs). Results: Out of 147,153 reports with VEGFR-TKIs, 314 cases of AI were retained, mostly of which were serious (97.1%; hospitalization recorded in 44.9%). In a combination regimen with ICIs (43% of cases), VEGFR-TKIs were discontinued in 52.2% of the cases (26% as monotherapy). The median time to onset was 72 days (IQR = 14–201; calculated for 189 cases). A robust disproportionality signal emerged, also in comparison with other anticancer drugs (ROR = 2.71, 95%CI = 2.42–3.04; IC = 0.25, 95%CI = 0.07–0.39). Cabozantinib, sunitinib and axitinib generated robust disproportionality even after ROR adjustment. Conclusions: We call pharmacologists, internists, oncologists and endocrinologists to raise awareness of serious AI with VEGFR-TKIs, and to develop dedicated guidelines, especially for combination regimens with immunotherapy.
Role of Sirtuins in the Pathobiology of Onco-Hematological Diseases: A PROSPERO-Registered Study and In Silico Analysis
Authors: Goes João Vitor Caetano , Carvalho Luiz Gustavo , de Oliveira Roberta Taiane Germano , Melo Mayara Magna de Lima , Novaes Lázaro Antônio Campanha , Moreno Daniel Antunes , Gonçalves Paola Gyuliane , Montefusco-Pereira Carlos Victor , Pinheiro Ronald Feitosa , Ribeiro Junior Howard Lopes
Published: September 2022

The sirtuins (SIRT) gene family (SIRT1 to SIRT7) contains the targets implicated in cellular and organismal aging. The role of SIRTs expression in the pathogenesis and overall survival of patients diagnosed with solid tumors has been widely discussed. However, studies that seek to explain the role of these pathways in the hematopoietic aging process and the consequences of their instability in the pathogenesis of different onco-hematological diseases are still scarce. Therefore, we performed a systematic review (registered in PROSPERO database #CRD42022310079) and in silico analysis (based on GEPIA database) to discuss the role of SIRTs in the advancement of pathogenesis and/or prognosis for different hematological cancer types. In summary, given recent available scientific evidence and in silico gene expression analysis that supports the role of SIRTs in pathobiology of hematological malignances, such as leukemias, lymphomas and myeloma, it is clear the need for further high-quality research and clinical trials that expands the SIRT inhibition knowledge and its effect on controlling clonal progression caused by genomic instability characteristics of these diseases. Finally, SIRTs represent potential molecular targets in the control of the effects caused by aging on the failures of the hematopoietic system that can lead to the involvement of hematological neoplasms.
A Calix[8]arene-Based Catalyst for Suzuki–Miyaura Couplings with Reduced Pd_Leaching
Authors: Adhel Erika , Labattut Axel , Naret Timothée , Dragoe Diana , Huc Vincent
Published: September 2022

Pd-catalysed reactions are amongst the most important in current chemistry. Consequently, very reactive catalysts were developed during the last decades, allowing very high conversions at low catalytic rates. However, decreasing Pd leaching in final products without decreasing catalyst efficiency remains an unsolved issue, especially in the pharma industry. We recently showed that using calixarenes as platforms for Pd-based catalysts constitutes an efficient answer to this concern. In the present work, we show that using these calixarenic platforms in combination with suitably engineered ligands allows for an even more strongly decreased Pd leaching. It thus opens up interesting perspectives for the synthesis of new families of catalysts combining a very high reactivity and a very low Pd leaching in final products.
The Complex Relation between Atrial Cardiomyopathy and Thrombogenesis
Authors: D’Alessandro Elisa , Winters Joris , van Nieuwenhoven Frans A. , Schotten Ulrich , Verheule Sander
Published: September 2022

Heart disease, as well as systemic metabolic alterations, can leave a ‘fingerprint’ of structural and functional changes in the atrial myocardium, leading to the onset of atrial cardiomyopathy. As demonstrated in various animal models, some of these changes, such as fibrosis, cardiomyocyte hypertrophy and fatty infiltration, can increase vulnerability to atrial fibrillation (AF), the most relevant manifestation of atrial cardiomyopathy in clinical practice. Atrial cardiomyopathy accompanying AF is associated with thromboembolic events, such as stroke. The interaction between AF and stroke appears to be far more complicated than initially believed. AF and stroke share many risk factors whose underlying pathological processes can reinforce the development and progression of both cardiovascular conditions. In this review, we summarize the main mechanisms by which atrial cardiomyopathy, preceding AF, supports thrombogenic events within the atrial cavity and myocardial interstitial space. Moreover, we report the pleiotropic effects of activated coagulation factors on atrial remodeling, which may aggravate atrial cardiomyopathy. Finally, we address the complex association between AF and stroke, which can be explained by a multidirectional causal relation between atrial cardiomyopathy and hypercoagulability.
Comparison of Alliin Recovery from Allium sativum L. Using Soxhlet Extraction and Subcritical Water Extraction
Authors: Zaini Ahmad Syahmi , Putra Nicky Rahmana , Idham Zuhaili , Mohd Faizal Azrul Nurfaiz , Che Yunus Mohd Azizi , Mamat Hasmadi , Abdul Aziz Ahmad Hazim
Published: September 2022

Garlic (Allium sativum L.) is an herbaceous plant and is recognised for its numerous medicinal and culinary properties, and it is used in diverse food preparations for its characteristic flavour and aroma. High alliin content increases the formation of allicin, a bioactive compound of garlic. Therefore, this research aimed to compare different extraction methods for garlic (Allium sativum L.) between subcritical water extraction (SWE) and Soxhlet extraction to obtain a high extraction yield and alliin content. The SWE conditions were 120 °C and 180 °C temperatures and 2 mL/min and 6 mL/min flow rates at a constant pressure of 15 MPa for a 10 min extraction time, respectively. In the meanwhile, the extraction time for Soxhlet extraction with various solvents, namely, distilled water, ethanol–water (1:1), and 100% ethanol, was two hours. High-performance liquid chromatography (HPLC) was used to analyse alliin. Soxhlet extraction had the best yield (1.96 g) using ethanol–water (1:1) as the solvent in comparison to SWE extraction (1.28 g) at 180 °C and 6 mL/min. In contrast, SWE yielded a greater concentration of alliin (136.82 mg/g) at 120 °C and 2 mL/min than the Soxhlet method when using distilled water as the solvent (65.18 mg/g). Therefore, SWE may replace Soxhlet extraction as the conventional method for extracting alliin from garlic at a high concentration, and SWE has advantages that favour garlic extracts.
Sensory Processing Impairments in Children with Developmental Coordination Disorder
Authors: Tran Huynh-Truc , Li Yao-Chuen , Lin Hung-Yu , Lee Shin-Da , Wang Pei-Jung
Published: September 2022

The two objectives of this systematic review were to examine the following: (1) the difference in sensory processing areas (auditory, visual, vestibular, touch, proprioceptive, and multi-sensory) between children with and without developmental coordination disorder (DCD), and (2) the relationship between sensory processing and motor coordination in DCD. The following databases were comprehensively searched for relevant articles: PubMed, Science Direct, Web of Science, and Cochrane library. There were 1107 articles (published year = 2010 to 2021) found in the initial search. Full-text articles of all possibly relevant citations were obtained and inspected for suitability by two authors. The outcome measures were sensory processing impairments and their relationship with motor coordination. A total of 10 articles met the inclusion criteria. Children with DCD showed significant impairments in visual integration, tactile integration, proprioceptive integration, auditory integration, vestibular integration, and oral integration processes when compared with typically developing children. Evidence also supported that sensory processing impairments were associated with poor motor coordination in DCD. Preliminary support indicated that DCD have sensory processing impairments in visual, tactile, proprioceptive, auditory, and vestibular areas, which might contribute to participation restriction in motor activities. It is important to apply sensory integration therapy in rehabilitation programs for DCD in order to facilitate participation in daily activities.
Successful Pulmonary Endarterectomy after Acute Pulmonary Embolism and Reversal of Acute Cor Pulmonale in an 11-Year-Old Boy with Nephrotic Syndrome
Authors: Osakwe Onyekachukwue , B. Das Bibhuti
Published: September 2022

Patients with nephrotic syndrome (NS) are at an increased risk for thromboembolic events, such as deep venous and arterial thrombosis and pulmonary embolism (PE). In general, PE in children differs from adults in incidence, predisposition, pathophysiology, presenting symptoms, and management strategies. There is a lack of treatment guidelines for PE in children, and the management strategies are mostly extrapolated from adult data. This case report highlights the presentation of acute cor pulmonale due to massive PE associated with NS and a successful pulmonary endarterectomy that reversed the child’s pulmonary hypertension and normalized right ventricular function.
Novel 3D Printed Resin Crowns for Primary Molars: In Vitro Study of Fracture Resistance, Biaxial Flexural Strength, and Dynamic Mechanical Analysis
Authors: Kim Nayoung , Kim Hoon , Kim Ik-Hwan , Lee Jiho , Lee Ko Eun , Lee Hyo-Seol , Kim Jee-Hwan , Song Je Seon , Shin Yooseok
Published: September 2022

This study evaluated the fracture resistance, biaxial flexural strength (BFS), and dynamic mechanical analysis (DMA) of three-dimensional (3D) printing resins for the esthetic restoration of primary molars. Two 3D printing resins, Graphy (GP) and NextDent (NXT), and a prefabricated zirconia crown, NuSmile (NS), were tested. GP and NXT samples were 3D printed using the workflow recommended by each manufacturer. Data were collected and statistically analyzed. As a result of the fracture resistance test of 0.7-mm-thick 3D printed resin crowns with a thickness similar to that of the NS crown, there was no statistically significant difference among GP (1491.6 ± 394.6 N), NXT (1634.4 ± 289.3 N), and NS (1622.8 ± 323.9 N). The BFS of GP was higher for all thicknesses than that of NXT. Both resins showed high survival probabilities (more than 90%) when subjected to 50 and 150 MPa. Through DMA, the glass transition temperatures of GP and NXT were above 120 °C and the rheological behavior of GP and NXT according to temperature and frequency were analyzed. In conclusion, GP and NXT showed optimum strength to withstand bite forces in children, and 3D printed resin crowns could be an acceptable option for fixed prostheses of primary teeth.
Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy
Authors: Moliner-Calderón Elisenda , Verd Sergio , Leiva Alfonso , Ponce-Taylor Jaume , Ginovart Gemma , Moll-McCarthy Pia , Gelabert Catian , Figueras-Aloy Josep
Published: September 2022

Background. It has been well established that human milk feeding contributes to limiting lung diseases in vulnerable neonates. The primary aim of this study was to compare the need for mechanical ventilation between human milk-fed neonates with sepsis and formula-fed neonates with sepsis. Methods. All late preterm and full-term infants from a single center with sepsis findings from 2002 to 2017 were identified. Data on infant feeding during hospital admission were also recorded. Multivariate logistic regression analyses were performed to assess the impact of feeding type on ventilation support and main neonatal morbidities. Results. The total number of participants was 322 (human milk group = 260; exclusive formula group = 62). In the bivariate analysis, 72% of human milk-fed neonates did not require oxygen therapy or respiratory support versus 55% of their formula-fed counterparts (p < 0.0001). Accordingly, invasive mechanical ventilation was required in 9.2% of any human milk-fed infants versus 32% of their exclusively formula-fed counterparts (p = 0.0085). These results held true in multivariate analysis; indeed, any human milk-fed neonates were more likely to require less respiratory support (OR = 0.44; 95% CI:0.22, 0.89) than those who were exclusively formula-fed. Conclusion. Human milk feeding may minimize exposure to mechanical ventilation.
Clinical and Instrumental Follow-Up of Childhood Absence Epilepsy (CAE): Exploration of Prognostic Factors
Authors: Amianto Federico , Davico Chiara , Bertino Federica , Bartolini Luca , Vittorini Roberta , Vacchetti Martina , Vitiello Benedetto
Published: September 2022

Background: Idiopathic generalized epilepsies (IGEs) represent 15–20% of all cases of epilepsy in children. This study explores predictors of long-term outcome in a sample of children with childhood absence epilepsy (CAE). Methods: The medical records of patients with CAE treated at a university paediatric hospital between 1995 and 2022 were systematically reviewed. Demographics and relevant clinical data, including electroencephalogram, brain imaging, and treatment outcome were extracted. Outcomes of interest included success in seizure control and seizure freedom after anti-seizure medication (ASM) discontinuation. An analysis of covariance using the diagnostic group as a confounder was performed on putative predictors. Results: We included 106 children (age 16.5 ± 6.63 years) with CAE with a mean follow-up of 5 years. Seizure control was achieved in 98.1% (in 56.6% with one ASM). Headache and generalized tonic-clonic seizures (GTCS) were more frequent in children requiring more than one ASM (p < 0.001 and p < 0.002, respectively). Of 65 who discontinued ASM, 54 (83%) remained seizure-free, while 11 (17%) relapsed (mean relapse time 9 months, range 0–18 months). Relapse was associated with GTCS (p < 0.001) and number of ASM (p < 0.002). Conclusions: A history of headache or of GTCS, along with the cumulative number of ASMs utilized, predicted seizure recurrence upon ASM discontinuation. Withdrawing ASM in patients with these characteristics requires special attention.
Evaluation of the Regenerative Potential of Platelet-Lysate and Platelet-Poor Plasma Derived from the Cord Blood Units in Corneal Wound Healing Applications: An In Vitro Comparative Study on Corneal Epithelial Cells
Authors: Mallis Panagiotis , Michalopoulos Efstathios , Sarri Eirini Faidra , Papadopoulou Elena , Theodoropoulou Vasiliki , Katsimpoulas Michalis , Stavropoulos-Giokas Catherine
Published: September 2022

Background: Cord blood platelet lysate (CB-PL) and cord blood platelet poor plasma (CB-PPP) have been applied with success in wound healing applications. Pathologies such as Sjogrens’s Syndrome (SS) and chronic graft versus host disease (cGVHD) can lead to severe ophthalmology issues. The application of CB-PL and CB-PPP may be strongly considered for damaged cornea healing. This study aimed to the evaluation of the beneficial properties of CB-PL and CB-PPP in corneal wound healing applications. Methods: Initially, the CB-PL and CB-PPP were produced from donated cord blood units (CBUs), followed by biochemical analysis. Corneal epithelial cells (CECs) were isolated from wistar rats and then cultured with medium containing 20% v/v either of CB-PL or CB-PPP. To define the impact of CB-PL and CB-PPP, biochemical, morphological analysis, scratch-wound assays, and immunoassays in CECs were performed. Results: CB-PL and CB-PPP were characterized by good biochemical parameters, regarding their quality characteristics and biomolecule content. CECs’ morphological features did not change after their cultivation with CB-PL or CB-PPP. A scratch wound assay and molecular analysis of CECs expanded with CB-PL indicated higher migratory capacity compared to those cultured with CB-PPP. Conclusion: CB-PL and CB-PPP exhibited good properties with respect to cell migration and proliferation, and could be considered an alternative source for eye drop production, to possibly be used in cornea wound healing applications.
Decision-Making Capacity to Refuse Treatment at the End of Life: The Need for Recognizing Real-World Practices
Authors: Akabayashi Akira , Nakazawa Eisuke , Ino Hiroyasu
Published: September 2022

End-of-life decision making is a troublesome ethical dilemma. These decisions should be made in trustful patient–doctor relationships. We aimed to propose a balanced approach when discussing this complex issue. We categorized the research into four approaches and suggest that a multidisciplinary approach may be appropriate. We also analyzed the pitfalls of the multidisciplinary approach. Our conclusion is two-fold. First, discussions in this field should be based on real-world practice. If this is not the case, the proposal may be armchair theory, which is not effective in a clinical setting. Second, interdisciplinary researchers should not stick to their position too firmly and should listen to others. Otherwise, proposals made will be paternalistic or philosophically biased. Therefore, when philosophical collaboration is applied to the topic of clinical bioethics, it is necessary to thoroughly examine different positions and carry out careful discussions with consideration for medical care settings. Researchers must also understand what is needed for a trustful patient–doctor relationship. By making such efforts, clinical bioethics will contribute to the wellbeing of patients.
Influence of the Addition of Sialon and Aluminum Nitride Fillers on the Photocuring Process of Polymer Coatings
Authors: Robakowska Mariola , Gierz Łukasz , Mayer Paulina , Szcześniak Katarzyna , Marcinkowska Agnieszka , Lewandowska Aneta , Gajewski Piotr
Published: September 2022

This article presents the results of a study on polymer coatings containing poly ethoxylated bisphenol A diacrylate (Bis-AEA10) with aluminum silicon nitride oxide (Sialon) and aluminum nitride (AlN). The polymer coatings were obtained by the photopolymerization technique. Investigations were carried out to determine the effect of the AlN and Sialon content on the UV-curing kinetics, as well as on the mechanical (hardness), thermal (Tg, thermal stability), physicochemical (water contact angle), and structural properties of the polymer coatings. Polymerization rates were characterized as functions of double-bond conversion using the photo-Differential Scanning Calorymetry technique (photo-DSC). The results obtained showed that a small addition of sialon filler (3–5 wt.%) to Bis-AEA10 increases the photopolymerization rate of the varnish, while the addition of more Sialon decreases the rate of photopolymerization. However, for the systems containing AlN filler, the maximum polymerization rate was observed for samples containing 10 wt.% filler. In the case of a varnish composition containing AlN, the maximum polymerization rate is characterized by the system containing 10 wt.% of AlN. This shows that the AlN filler has a good influence on the polymerization process. In either case, the final double bond conversion was high (80%–95%). Mechanical tests have shown that introducing the filler into the polymer matrix increases its hardness. The content of Sialon and AlN in the coatings causes an increase (up to 4–5 wt.%) and a decrease (>4–5 wt.%) in the glass transition temperature. The effect of the addition of fillers on the physicochemical properties of the coating surface has also been investigated and characterized by the water contact angle method. The addition of 20 wt.% Sialon and AlN increased the contact angle of the samples by approximately 40% and 31%, respectively, resulting in coatings with hydrophobic surface properties.
A Prognostic Nomogram Based on Log Odds of Positive Lymph Nodes to Predict Overall Survival for Non-Metastatic Bladder Cancer Patients after Radical Cystectomy
Authors: Yang Jingtian , Huang Huasheng , Li Wenshuang , Ran Shengming , Hu Jintao , Zhang Yishan , Li Wenjie , Chen Changhao , He Wang
Published: September 2022

(1) Purpose: The purpose of this study was to evaluate the prognostic capacity of the pathological N status (pN), lymph node ratio (LNR), and the log odds of positive lymph nodes (LODDS), and to build a prognostic nomogram to predict overall survival (OS) for bladder cancer patients treated by radical cystectomy. (2) Methods: The clinical and pathological characteristics of 10,938 patients with bladder cancer were identified from the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2017. The predictive capacity was assessed by univariate and multivariate Cox regression analyses, the area under the receiver operating characteristic curve (AUC), and C-index. Calibration curves, decision curve analysis (DCA), and risk-grouping were utilized to evaluate the predictive accuracy and discriminative ability of the nomogram. (3) Results: LODDS was an independent risk factor for bladder cancer (all p < 0.001) and demonstrated the highest values of C-index and AUC. The values of AUCs in the training cohort were 0.747, 0.743, and 0.735 for predicting 1-, 3-, and 5-year OS, respectively. Calibration curves and DCA curves suggested the excellent clinical application value of our nomogram. (4) Conclusions: LODDS is a better predictive indicator for bladder cancer patients compared to pN and LNR. The LODDS-incorporated nomogram has excellent accuracy and promising clinical application value for non-metastatic bladder cancer after radical cystectomy.
Crosstalk between Immune Checkpoint Modulators, Metabolic Reprogramming and Cellular Plasticity in Triple-Negative Breast Cancer
Authors: Poddar Arpita , Rao Sushma R. , Prithviraj Prashanth , Kannourakis George , Jayachandran Aparna
Published: September 2022

Breast cancer is one of the major causes of mortality in women worldwide. Accounting for 15–20% of all breast cancer diagnoses, the triple-negative breast cancer (TNBC) subtype presents with an aggressive clinical course, heightened metastatic potential and the poorest short-term prognosis. TNBC does not respond to hormonal therapy, only partially responds to radio- and chemotherapy, and has limited targeted therapy options, thus underlining the critical need for better therapeutic treatments. Although immunotherapy based on immune checkpoint inhibition is emerging as a promising treatment option for TNBC patients, activation of cellular plasticity programs such as metabolic reprogramming (MR) and epithelial-to-mesenchymal transition (EMT) causes immunotherapy to fail. In this report, we review the role of MR and EMT in immune checkpoint dysregulation in TNBCs and specifically shed light on development of novel combination treatment modalities for this challenging disease. We highlight the clinical relevance of crosstalk between MR, EMT, and immune checkpoints in TNBCs.
Diversity and Variation of Epiphytic Diatoms on Ruppia maritima L., Related to Anthropogenic Impact in an Estuary in Southern Brazil
Authors: da Rosa Vanessa Corrêa , Copertino Margareth
Published: September 2022

Knowledge about the diversity and spatiotemporal variability of epiphytic diatom communities in estuarine meadows has great relevance for coastal ecology and, thus, contributes to understanding the impact of natural and anthropogenic changes on seagrass meadows. The community of epiphytic diatoms in Ruppia maritima L. meadows was investigated in two environments with different levels of anthropogenic impact and nutrient loads. Both impacted and non-impacted meadows had similar conditions in terms of water depth, temperature and transparency but distinct nutrient loads and salinity ranges. A total of 159 diatom taxa were found on Ruppia maritima leaves during the monitoring period, including freshwater (30.8%), marine (25.1%), brackish (9.4%) and cosmopolitan (8.8%) taxa. The most abundant species were C. placentula, T. tabulata, M. pumila and T. fasciculata, in addition to A. tenuissimus, C. adhaerens and M. moniliformis. Although present in both sites, C. placentula and T. tabulata were the dominant species in the impacted site. We found that 32% of the taxa were exclusive to the non-impacted site, 23% to the impacted site and 45% were common to both sites. The study sites showed marked differences in community attributes; i.e., higher richness, diversity and equitability and lower dominance were found in the non-impacted site, which is distant from anthropogenic sources of domestic and industrial sewage and has low concentrations of dissolved N and P in water and low values of sediment organic matter. Nutrient concentration and salinity were the main factors behind the spatial and temporal variability in the structure of the epiphytic community when all other environmental variables were similar (water depth, temperature, transparency and host plant). The influence of temperature and salinity on community structure was site-dependent. This study revealed the high richness and diversity of epiphytic diatoms in the meadows of the Patos Lagoon estuary (PLE) and the high spatial and temporal heterogeneity of the communities, and it shows the potential of epiphytic community studies for the assessment of environmental quality in seagrass meadow habitats.
Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy
Authors: Hwang Jae Pil , Choi Joon Young , Choi Joon Ho , Cho Young Seok , Hur Sung Mo , Kim Zisun , Lim Cheol Wan , Seo Seongho , Moon Ji Eun , Woo Sang-Keun , Park Jung Mi
Published: September 2022

Background: This study investigated the prognostic value of axillary lymph node (ALN) heterogeneity texture features through 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with locally advanced breast cancer (LABC). Methods: We retrospectively analyzed 158 LABC patients with FDG-avid, pathology-proven, metastatic ALN who underwent neoadjuvant chemotherapy (NAC) and curative surgery. Tumor and ALN texture parameters were extracted from pretreatment 18F-FDG PET/CT using Chang-Gung Image Texture Analysis software. The least absolute shrinkage and selection operator regression was performed to select the most significant predictive texture parameters. The predictive impact of texture parameters was evaluated for both progression-free survival and pathologic NAC response. Results: The median follow-up period of 36.8 months and progression of disease (PD) was observed in 36 patients. In the univariate analysis, ALN textures (minimum standardized uptake value (SUV) (p = 0.026), SUV skewness (p = 0.038), SUV bias-corrected Kurtosis (p = 0.034), total lesion glycolysis (p = 0.011)), tumor textures (low-intensity size zone emphasis (p = 0.045), minimum SUV (p = 0.047), and homogeneity (p = 0.041)) were significant texture predictors. On the Cox regression analysis, ALN SUV skewness was an independent texture predictor of PD (p = 0.016, hazard ratio 2.3, 95% confidence interval 1.16–4.58). Conclusions: ALN texture feature from pretreatment 18F-FDG PET/CT is useful for the prediction of LABC progression.
Atypical Sites of the Lipoma on the Hand and Fingers: Clinical and Imaging Features and Surgical Outcomes
Authors: Pertea Mihaela , Lunca Sorinel , Filip Alexandru , Moraru Dan Cristian , Carp Claudiu , Pinzaru Roxana , Poroch Vladimir , Veliceasa Bogdan
Published: September 2022

Background: Lipomas are the most frequent benign soft tissue tumor that are rarely found in the hand and are exceptionally rare on the fingers. The aim of this study was to investigate lipomas of atypical locations, so that they can be taken into account when making a differential diagnosis of a tumor of the hand or fingers. Methods: We studied a group of 27 patients diagnosed with lipoma of the wrist, palm, and fingers. The diagnosis was made by clinical and imaging examinations. Surgical treatment was established based on symptoms of pain, paresthesias, functional impairment, or aesthetic concerns. Treatment outcomes were assessed clinically at 1.5 years post-intervention. Results: Sizes over 5 cm were recorded in five cases, with the largest lipoma being 8 by 5 by 3.5 cm in size and weighing 125 g, located in the palm. There was one case of spontaneous tendon rupture and one case of carpal tunnel syndrome. There was no recurrence recorded at 1.5-year follow-up. Conclusions: Lipomas in the palm and fingers are rare entities (with more men affected), and surgical treatment consists of complete removal of the tumor and providing definitive healing. Despite their rarity, clinicians should consider lipomas when making differential diagnoses of soft tissue tumors of the hand.
Ultrasound Methods for the Assessment of Liver Steatosis: A Critical Appraisal
Authors: Bozic Dorotea , Podrug Kristian , Mikolasevic Ivana , Grgurevic Ivica
Published: September 2022

The prevalence of the non-alcoholic fatty liver disease has reached major proportions, being estimated to affect one-quarter of the global population. The reference techniques, which include liver biopsy and the magnetic resonance imaging proton density fat fraction, have objective practical and financial limitations to their routine use in the detection and quantification of liver steatosis. Therefore, there has been a rising necessity for the development of new inexpensive, widely applicable and reliable non-invasive diagnostic tools. The controlled attenuation parameter has been considered the point-of-care technique for the assessment of liver steatosis for a long period of time. Recently, many ultrasound (US) system manufacturers have developed proprietary software solutions for the quantification of liver steatosis. Some of these methods have already been extensively tested with very good performance results reported, while others are still under evaluation. This manuscript reviews the currently available US-based methods for diagnosing and grading liver steatosis, including their classification and performance results, with an appraisal of the importance of this armamentarium in daily clinical practice.
Evaluation of Smiles for Life: A Caregiver Focused Oral Health Education Programme
Authors: Wilson Nathan J. , Patterson-Norrie Tiffany , Bedford Cheryl , Bergstedt Natalie , Mendoza Lia Marri , Villarosa Amy R. , George Ajesh , Karve Avanti
Published: September 2022

Background: People with an intellectual and/or developmental disability are at increased risk of adverse oral health outcomes and often require support from caregivers to assist in maintaining or seeking treatment for their oral health needs. However, caregivers and support workers are often family members with limited formal oral health training. Hence, the aim of this pilot study was to review the outcomes of the ‘Smiles for Life’ oral health education workshop with reference to their knowledge, attitudes, and practices of caregivers of people with an intellectual or developmental disability. Methods: A single group pre-test post-test intervention design was used to explore the preliminary effectiveness and appropriateness of the Smiles for Life oral health education workshop. Results: A total of 244 participants completed both the pre and post knowledge test. Oral health literacy scores decreased following the post test. Those with higher levels of education achieved higher post-training knowledge scores. Overall, caregivers reported satisfaction on the material presented however, it could be improved with more practical demonstrations. Conclusion: Providing an oral health education tool that caters to the diverse caregiver audience presents a unique set of challenges, despite oral health education in this professional group being vital. Future studies may benefit from reviewing the efficacy of a more tailored educational intervention.
Deep Learning and Artificial Neural Networks for Spacecraft Dynamics, Navigation and Control
Authors: Silvestrini Stefano , Lavagna Michèle
Published: September 2022

The growing interest in Artificial Intelligence is pervading several domains of technology and robotics research. Only recently has the space community started to investigate deep learning methods and artificial neural networks for space systems. This paper aims at introducing the most relevant characteristics of these topics for spacecraft dynamics control, guidance and navigation. The most common artificial neural network architectures and the associated training methods are examined, trying to highlight the advantages and disadvantages of their employment for specific problems. In particular, the applications of artificial neural networks to system identification, control synthesis and optical navigation are reviewed and compared using quantitative and qualitative metrics. This overview presents the end-to-end deep learning frameworks for spacecraft guidance, navigation and control together with the hybrid methods in which the neural techniques are coupled with traditional algorithms to enhance their performance levels.
Natural Fractals as Irreversible Disorder: Entropy Approach from Cracks in the Semi Brittle-Ductile Lithosphere and Generalization
Authors: Venegas-Aravena Patricio , Cordaro Enrique G. , Laroze David
Published: September 2022

The seismo-electromagnetic theory describes the growth of fractally distributed cracks within the lithosphere that generate the emission of magnetic anomalies prior to large earthquakes. One of the main physical properties of this theory is their consistency regarding the second law of thermodynamics. That is, the crack generation of the lithosphere corresponds to the manifestation of an irreversible process evolving from one steady state to another. Nevertheless, there is still not a proper thermodynamic description of lithospheric crack generation. That is why this work presents the derivation of the entropy changes generated by the lithospheric cracking. It is found that the growth of the fractal cracks increases the entropy prior impending earthquakes. As fractality is observed across different topics, our results are generalized by using the Onsager’s coefficient for any system characterized by fractal volumes. It is found that the growth of fractality in nature corresponds to an irreversible process.
Foreign Direct Investment and Exports Stimulate Economic Growth? Evidence of Equilibrium Relationship in Peru
Authors: Bazán Navarro Ciro Eduardo , Álvarez-Quiroz Víctor Josué
Published: September 2022

The purpose of this research is to estimate the dynamic impacts of foreign direct investments (FDI) and exports on economic growth in Peru (1970–2020) using annual series. Starting with the theoretical Mundell–Fleming static model with assumptions, we find that the change in exports does not affect GDP, and the effect of FDI on GDP can be positive or negative depending on the comparison between the slopes of the IS and LM curves. The variables are foreign direct investment net flow (% of GDP), exports of goods and services (% of GDP), and GDP growth rate (%). FDI and exports constitute first-order integrated processes; meanwhile, the GDP growth rate is a stationary process. The Granger causality evidences feedback between GDP and exports and the FDI-led growth hypothesis. Considering the dependent variable GDP growth rate, the autoregressive distributed lag cointegration bound test shows the findings regarding the cointegration consist of positive long-term equilibrium impacts from exports and FDI on GDP. Estimating an error correction model, in the short-term, the FDI explains to GDP and the exports have an insignificant impact on economic growth in Peru. Finally, we conclude that Peru’s economic policy path should continue to attract foreign capital to increase FDI.
Providing Institutional Support for Academic Engagement in Online and Blended Learning Programs
Authors: Tuiloma Sara , Graham Charles R. , Arias Adriana María Martinez , Caicedo Diana Maria Parra
Published: September 2022

In this paper, we examine how universities can evaluate the level of support they provide to help their students with affective, behavioral, and cognitive engagement in their online and blended learning experiences. Additionally, it identifies what types of supports help students engage academically and what barriers hinder their online engagement. Using a survey instrument sent to university students (n = 1295), we conducted a mixed-methods analysis to understand better how students feel the institution supports their online engagement and what barriers they experience. To accomplish this, we addressed the following research questions: (1) How do students feel the institution supports their academic engagement for online and blended learning (including affective, behavioral, and cognitive dimensions)? and (2) What are the barriers to student academic engagement for online and blended learning at the institutional level? We used the Academic Communities of Engagement (ACE) framework as a lens for understanding the types of support institutions should provide in online and blended learning programs. While our descriptive statistics revealed that students might not distinguish the types of support they receive, the qualitative findings suggested they need more behavioral support. Our results also showed that 31% of students reported they experienced three or more barriers to their learning, which should be addressed when considering institutional support elements.
Broadening the Definition of ‘Research Skills’ to Enhance Students’ Competence across Undergraduate and Master’s Programs
Authors: Vieno Kayla , Rogers Kem A. , Campbell Nicole
Published: September 2022

Undergraduate and master’s programs—thesis- or non-thesis-based—provide students with opportunities to develop research skills that vary depending on their degree requirements. However, there is a lack of clarity and consistency regarding the definition of a research skill and the components that are taught, practiced, and assessed. In response to this ambiguity, an environmental scan and a literature search were conducted to inform the creation of a comprehensive list of research skills that can be applied across programs and disciplines. Although published studies directly comparing research skills in thesis and non-thesis programs were limited, the specific skills reported in each program type were similar. This viewpoint article identifies the following seven research skills that were most frequently reported across both thesis and non-thesis programs: critical appraisal, information synthesis, decision making, problem solving, data collection, data analysis, and communication. When contextualized appropriately, these skills can be useful for a student during their academic program and are transferable across a range of future career pathways. Broadening the definition of “research skills” can inform curricular updates and program development, independent of their program type, to ensure that students are presented with explicit opportunities to develop the skills needed to succeed in their educational and occupational endeavours.
Modeling and Simulation of Magnetic Balance Current Sensor Based on Magnetic Scalar Potential Volume Integral
Authors: Ni Dacheng , Luo Derong , Huang Shoudao , Lv Yang
Published: September 2022

In this paper, a field–circuit combined simulation method, based on the magnetic scalar potential volume integral equation (MSP-VIE) and its fast algorithms, are proposed for the transient simulation and nonlinear distortion analysis of the magnetic balance current sensor. The magnetic part of the sensor is modeled and simulated by MSP-VIE with the field matrices extracted by the method of moments. By directly implementing the magnetic field equation in the circuit, these field matrices can be regarded as equivalent circuit parameters of the magnetic part, to construct the corresponding SPICE model. Finally, the field–circuit combined model of the entire sensor is unified in a circuit, so with the SPICE solver, the transient simulation is accomplished in the time domain. Moreover, aiming at the time-consuming problem, this paper presents a corresponding fast method to accelerate the simulation. The comparison of measurement and simulation demonstrates that the proposed method not only realizes the transient simulation of the whole sensor, but also simulates some hidden performance details; thus, it can be applied to practical engineering, to guide and test the early design of the product.
Development of an Android Mobile Application for Reducing Sitting Time and Increasing Walking Time in People with Type 2 Diabetes
Authors: Daryabeygi-Khotbehsara Reza , Shariful Islam Sheikh Mohammed , Dunstan David W. , Abdelrazek Mohamed , Markides Brittany , Pham Thien , Maddison Ralph
Published: September 2022

Breaking up prolonged sitting with short bouts of light physical activity including standing and walking has been shown to be beneficial for people with type 2 diabetes (T2D). This paper presents the development of an android mobile app to deliver a just-in-time adaptive intervention (JITAI) to reduce sedentary time in people with T2D. A total of six design workshops were conducted with seven experts to identify design requirements, a behavioural framework, and required contextual adaptations for the development of a bespoke mobile app (iMOVE). Moreover, a focus group was conducted among people with T2D as potential end-users (N = 10) to ascertain their perceptions of the app. Feedback from the focus group was used in subsequent iterations of the iMOVE app. Data were analysed using an inductive qualitative thematic analysis. Based on workshops, key features of iMOVE were developed, including simplicity (e.g., navigation, login), colours and font sizes, push notifications, messaging algorithms, and a triggering system for breaking up sitting time and moving more. Based on the user testing results, a goal-setting tab was added, font sizes were made larger, the brightness of colours was reduced, and a colour indicator was used to indicate device connectivity with an activity tracker. A user-centric app was developed to support people with T2D to transition from sedentary to active lifestyles.
Heterogeneous and Monolithic 3D Integration Technology for Mixed-Signal ICs
Authors: Jeong Jaeyong , Geum Dae-Myeong , Kim SangHyeon
Published: September 2022

For next-generation system-on-chips (SoCs) in diverse applications (RF, sensor, display, etc.) which require high-performance, small form factors, and low power consumption, heterogeneous and monolithic 3D (M3D) integration employing advanced Si CMOS technology has been intriguing. To realize the M3D-based systems, it is important to take into account the relationship between the top and bottom devices in terms of thermal budget, electrical coupling, and operability when using different materials and various processes during integration and sequential fabrication. In this paper, from this perspective, we present our recent progress of III-V devices on Si bottom devices/circuits for providing informative guidelines in RF and imaging devices. Successful fabrication of the high-performance InGaAs high electron mobility transistors (HEMTs) on the bottom ICs, with a high unity current gain cutoff frequency (fT) and unity power gain cutoff frequency (fMAX) was accomplished without substrate noise. Furthermore, the insertion of an intermediate metal plate between the top and bottom devices reduced the thermal interaction. Furthermore, the InGaAs photodetectors (PDs) were monolithically integrated on Si bottom devices without thermal damage due to low process temperature. Based on the integrated devices, we successfully evaluated the device scalability using sequential fabrication and basic readout functions of integrated circuits.