bluuebunny/crossref_metadata_2025 huggingface dataset:
PENERAPAN APLIKASI SIPEDIS (SISTEM PENEGAKAN DISIPLIN) PADA KPPBC TMP B MAKASSAR
Authors: Saktiawan Iwan
Published: December 2021

Direktorat Jenderal Bea dan Cukai dalam hal ini  Kantor Pengawasan dan Pelayanan Bea dan Cukai Tipe Madya Pabean B Makassar telah mengatur mekanisme penegakan disiplin kepada para pejabat dan pegawai di seluruh satuan kerja yang mulai dimplementasikan. Telah disusun butir-butir yang mengatur pegawai agar disiplin dalam berpakaian dinas seragam dan pakaian olah raga (untuk senam Jumat pagi), disiplin dalam kehadiran dan jam kerja, serta disiplin dalam sikap dan perilaku. Permasalahan yang terjadi dalam implementasinya adalah proses pencatatan pelanggaran pegawai yang dilakukan oleh Tim Penegak Disiplin masih secara manual, belum paperless, serta diperlukan transparansi yang dapat diakses secara real time atas kontrol kedisiplinan seluruh pegawai. Tujuan dari penelitian ini adalah untuk membuat sebuah sistem aplikasi pencatatan pelanggaran dalam proses penegakan disiplin secara elektronik yang memudahkan Tim Penegak Disiplin dalam melakukan administrasi pelanggaran. Penelitian ini merupakan bentuk penelitian terapan yang dilakukan dengan pendekatan kualitatif. Metode pengumpulan data yang digunakan melalui observasi, wawancara, telaah dokumen, dan dokumentasi untuk mendapatkan informasi-informasi yang berhubungan dengan pengembangan pegawai dan informan dalam penelitian ini berjumlah 3 (tiga) orang. Penelitian ini menghasilkan sebuah aplikasi sebagai solusi memudahkan proses penegakan disiplin yang berbasis aplikasi, dapat diakses secara mobile, sehingga diharapkan dapat meningkatkan kedisiplinan pegawai, serta sarana monitoring pimpinan terhadap tingkat pelanggaran disiplin. Oleh karena itu, demi kelancaran proses penegakan disiplin pegawai di dalam organisasi, diperlukan pemanfaatan SIPEDIS (Sistem Penegakan Disiplin) sebagai sarana yang mampu memberikan kemudahan dalam implementasinya.
Antioxidative Effect of Dietary Flavonoid Isoquercitrin on Human Ovarian Granulosa Cells HGL5 In Vitro
Authors: KOLESAROVA A , MICHALCOVA K , ROYCHOUDHURY S , BALDOVSKA S , TVRDA E , VASICEK J , CHRENEK P , SANISLO L , KREN V
Published: December 2021

This study aimed to examine the effect of dietary flavonoid isoquercitrin on ovarian granulosa cells using the immortalized human cell line HGL5. Cell viability, survival, apoptosis, release of steroid hormones 17β-estradiol and progesterone, and human transforming growth factor-β2 (TGF-β2) and TGF-β2 receptor as well as intracellular reactive oxygen species (ROS) generation were investigated after isoquercitrin treatment at the concentration range of 5-100 μg.ml-1. It did not cause any significant change (p>0.05) in cell viability as studied by AlamarBlue assay in comparison to control. No significant change was observed (p>0.05) in the proportion of live, dead and apoptotic cells as revealed by apoptotic assay using flow cytometry. Similarly, the release of 17β-estradiol, progesterone, TGF-β2 and its receptor were not affected significantly (p>0.05) by isoquercitrin as detected by ELISA, in comparison to control. Except for the highest concentration of 100 μg.ml-1, which led to oxidative stress, isoquercitrin exhibited antioxidative activity at lower concentration used in the study (5, 10, 25, and 50 μg.ml-1) by hampering the production of intracellular ROS, in comparison to control, as detected by chemiluminescence assay (p<0.05). Findings of the present study indicate an existence of the antioxidative pathway that involves inhibition of intracellular ROS generation by isoquercitrin in human ovarian granulosa cells.
Introduction to DOK2 and its Potential Role in Cancer
Authors: SUN P , LI R , MENG Y , XI S , WANG Q , YANG X , PENG X , CAI J
Published: December 2021

Cancer is a complex, multifactorial disease that modern medicine ultimately aims to overcome. Downstream of tyrosine kinase 2 (DOK2) is a well-known tumor suppressor gene, and a member of the downstream protein DOK family of tyrosine kinases. Through a search of original literature indexed in PubMed and other databases, the present review aims to extricate the mechanisms by which DOK2 acts on cancer, thereby identifying more reliable and effective therapeutic targets to promote enhanced methods of cancer prevention and treatment. The review focuses on the role of DOK2 in multiple tumor types in the lungs, intestines, liver, and breast. Additionally, we discuss the potential mechanisms of action of DOK2 and the downstream consequences via the Ras/MPAK/ERK or PI3K/AKT/mTOR signaling pathways.
Diabetic Amyotrophy: From the Basics to the Bedside
Authors: Albers James W. , Jacobson Ryan D. , Smyth David L.
Published: December 2021

Diabetic amyotrophy is a rare complication of diabetes compared to distal symmetric polyneuropathy, but can occasionally be encountered in clinical practice, particularly as the incidence of diabetes increases. The distinctive history of unilateral neuropathic symptoms followed rapidly by atrophy and weakness is typical of the disorder. This complication most commonly occurs in cases of well-controlled Type 2 diabetes mellitus. While the underlying pathophysiology is known to be microvasculitic in nature, the diagnosis is often based on clinical and electrodiagnostic grounds and tissue biopsy is not typically performed. Attempts at corticosteroid administration during immunotherapy should be carefully considered on a patient-by-patient basis. Better recognition of this disorder is likely to result in more rapid diagnosis, counselling, and subspecialty referral.
Expanding the Role of CAR-T Cell Therapy to Systemic Lupus Erythematosus
Authors: Patel Shreya , Brassil Kelly , Jungsuwadee Paiboon
Published: December 2021

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disorder resulting from autoantibodies produced by B-cell derived plasma cells. Clinical presentation ranges from mild skin rash to multiorgan failure. Regardless of the clinical presentation or severity of the disease, patients with SLE often require life-long treatment. Current treatment recommendations for SLE include hydroxychloroquine, glucocorticoids, immunomodulatory agents, cyclophosphamide, and biologic agents. Despite availability of these agents, the condition of some patients with SLE progressively worsens. With limited treatment options, new and novel therapeutic approaches are needed. Given the active role of B cells in the pathophysiology of SLE, they present an attractive target for therapies evolving in the oncology field. Amongst these, immune effector cell therapies, including chimeric antigen receptor (CAR)-T cell therapy, have proven beneficial in targeting B cells. The eradication of B cells, along with the potential for T cell persistence, has resulted in prolonged remission or stable disease. This review provides an overview of the pathophysiology of SLE; current treatment options, including monoclonal antibodies targeting cluster of differentiation-20 (CD20), CD22, and B cell-activating factor (BAFF); and explores why and how immune effector cell therapies may prove a promising therapeutic option for this patient population, particularly for individuals with refractory disease. Clinical implications from currently approved U.S. Food and Drug Administration (FDA) agents for haematologic malignancies are discussed and provide insight into considerations for applying this therapy to the patient population with SLE in the context of clinical trials.
Glanzmann Thrombasthenia: A Case Report of a Rare Inherited Coagulation Disorder Presenting with Traumatic Head Injury
Authors: Chakati Vishal , Bukka Durga Prasad , Erigaisi Srinivas Rao , Anchuri Shyam Sunder
Published: December 2021

This case study deals with a 32-year-old Indian male patient who presented with a traumatic head injury in the hospital, experienced uncontrolled bleeding after conducting surgery, and was eventually diagnosed with Glanzmann thrombasthenia. Glanzmann thrombasthenia is a rare hereditary blood clotting disorder characterised by a lack of platelet aggregation due to the absence of platelet glycoprotein IIb/IIIa. This occurrence is generally triggered by consanguineous marriages and is apparent in approximately one in one million people. Education and raising awareness about consanguinity in communities may help to reduce challenging, unusual genetic diseases.
FATAL CARDIOVASCULAR COLLAPSE DURING TRANS-AORTIC TRANSCATHETER AORTIC VALVE REPLACEMENT FOLLOWING INTRA-PROCEDURAL RETROGRADE TRANSCATHETER HEART VALVE MIGRATION INTO THE LEFT VENTRICULAR OUTFLOW TRACT
Authors: Jariwala Pankaj , Pandurang Jadhav Kartik , Sridhar Kale Satya , Sepur Lakshmana
Published: December 2021

Transcatheter heart valve retrograde migration after transcatheter aortic valve implantation is unusual. It can occur during the implantation of the aortic transcatheter heart valve, i.e., intra-procedural, or in the first few days following the intervention. Transcatheter valve embolisation and migration soon after deployment typically results from the implantation of a prothesis that was undersized for the annulus, an unreasonably low implantation, or the expulsion of the device following deployment by an excessive ventricular contraction. The presented case highlights the importance of the timing of the complication that has taken place, in this case, intra-procedural, which has become relevant to the research.
A New Approach to Percutaneously Treat Chronic Coronary Total Occlusions: The ‘Minimalistic Hybrid Approach’ Algorithm
Authors: Maria Vescovo Giovanni , Zivelonghi Carlo , Scott Benjamin , Wilgenhof Adriaan , Willemen Yannick , Convens Carl , Verheye Stefan , Vermeersch Paul , Agostoni Pierfrancesco
Published: December 2021

Vascular access-related complications are one of the most frequent issues following percutaneous interventions of chronic total occlusions (CTO) because of the traditional use of large introducer sheaths for more back-up catheter support, and the need for multiple access sites, often including femoral access. In current practice, many operators still approach the revascularisation of CTO through femoral access despite the demonstrated advantage of radial procedures, mostly in terms of incidence of bleeding complications. Recently, an alternative strategy to deal with CTO, with the aim to minimise the number of access-related complications without affecting the successful revascularisation rate, has been proposed: the ‘minimalistic hybrid approach’ algorithm. This approach consists of the use of classic ‘hybrid algorithm’ techniques, but also aims to minimise the number of access sites, the size of the catheters used, and the adoption of the femoral access.
Cutaneous Mucormycosis of the Interscapular Region in an Immunocompetent Patient
Authors: Doshi Pankil , Sanghvi Yash , Doctor Jwal , Parsaniya Vaibhavi
Published: December 2021

Mucormycosis is an invasive fungal infection caused by opportunistic fungi of the phylum Glomeromycotan, subphylum Mucormycotina, mainly affecting individuals with immunosuppression. Cutaneous mucormycosis is the third most common clinical form of the disease preceded by pulmonary and rhinocerebral mucormycosis. The usual factors predisposing to this infection are individuals who are immunocompromised with conditions like HIV, haematological malignancies, and diabetes mellitus, but a significant proportion of patients are immunocompetent. The agents of mucormycosis are abundantly present in nature and are transmitted to the skin by direct inoculation. It may be due to needle sticks, stings, and bites by animals, motor-vehicle accidents, natural disasters, and burn injuries. The clinical presentation is non-specific, but an indurated plaque that rapidly evolves to necrosis (eschar) is a common finding. The infection can invade locally, and also penetrate into the adjacent fat, muscle, fascia, and bone, or become disseminated. It is difficult to diagnose because of the non-specific presentation of mucormycosis. Biopsy and culture should be performed. Treatment consists of multidisciplinary management, including surgical debridement, use of antifungal drugs (amphotericin B and posaconazole), and reversal of underlying risk factors, when possible. Mortality rates are significant, ranging from 4% to 10% in localised mucormycosis infection, but are lower than the other forms of the disease. The authors present a case here of a 38-year-old immunocompetent male with cutaneous mucormycosis at the interscapular region.
Sonohysterography: A Formidable Diagnostic Tool in the Evaluation of the Caesarean Scar Defect in Comparison to MRI
Authors: Amreen Saika , Saldanha Cimona L. , Choh Naseer A. , Yaseen Yawar , Gojwari Tariq A.
Published: December 2021

Introduction: The use of the caesarean section (C-section) in obstetric care has exponentially increased in the past few decades. The caesarean scar defect (CSD) is a potential complication of C-section and is associated with a wide range of problems. The purpose of this study was to compare the evaluation of the CSD in non-pregnant women by sonohysterography (SHG) and MRI.

Methods: This study was performed in patients having undergone a single C-section more than 6 months prior, presenting with abnormal uterine bleeding, dysmenorrhoea, or pelvic pain. Since ultrasonography and pelvic examination were inconclusive, these patients underwent MRI followed by saline infusion SHG. Measurements and characteristics of the ‘niche’ were acquired from both MRI and SHG and compared for analysis.

Results: Patients with a single C-section presenting with prolonged bleeding, spotting, and dysmenorrhoea were included in this prospective study. SHG and MRI were used to measure scar thickness, width, depth, and adjacent myometrial thickness, in which the findings concurred. The mean defect depth was greater in patients with postmenstrual bleeding.

Conclusion: SHG is noninferior to MRI, and SHG has the potential to assess the dynamic status of the CSD, with morphological clarity.
Uterine Incision at the Fundus,Transitory Devascularisation, and Myometrial Resection for Uterine Preservation in Anterior Accretism: A Case Report
Authors: Maciel Rayra Amana Macêdo , Leal Caio Ribeiro Vieira , D’Abreu Bárbara Flecha , Júnior Mário Dias Corrêa , Filho Admário Silva Santos
Published: December 2021

Placenta accreta spectrum is a serious obstetric condition related to abnormal adherence of placental tissue to the myometrium and high maternal and fetal morbidity. In order to achieve the best outcome, the management of this condition must be carried out by an experienced multidisciplinary team and the individual characteristics of the patient must be taken into consideration, such as comorbidities and desire for reproductive preservation. This case report presents the conservative surgical management of placenta accreta spectrum in a 23-year-old patient who underwent an elective caesarean section with uterine preservation because of anterior placenta increta. The authors performed a transverse uterine incision at the fundus with transitory uterine devascularisation of the lower uterine segment with partial myometrial removal. This technique was successful for controlling the haemorrhage and preserving the uterus, with no complications.
Pathogenesis and Treatment of Refractory Oedema in Nephrotic Syndrome
Authors: Jethwani Priyanka , Krishnan Namrata
Published: December 2021

Oedema is a hallmark feature of nephrotic syndrome (NS) and can cause significant patient morbidity. The pathogenesis of oedema formation is complex and results from abnormalities in sodium retention, inter-play of neurohormonal factors, and changes in capillary filtration barrier. Salt retention is often primary (‘overfill’ theory) because of increased sodium-potassium adenosine triphosphatase activity in the collecting duct cells, increased direct epithelial sodium channel activation (ENaC) by urinary proteases (independent of aldosterone), and an overall increased effective arterial blood volume. However, a subset of patients with NS, especially children, demonstrate decreased effective arterial blood volume (‘underfill’ theory) and secondary sodium retention as the primary mechanism of oedema formation. Increased capillary permeability and vascular inflammation contributes as well. Loop diuretics with or without salt-poor albumin are the mainstay of therapy in adults, although no large clinical trials exist to guide diuretic choice or dosage. Combination diuretic therapy is recommended to achieve multi-site nephron blockade and overcome diuretic resistance, which is a frequent challenge. Use of direct ENaC inhibitors (amiloride) in combination with loop diuretics may be especially beneficial given the primary role of ENaC in sodium retention. Aquaretics such as vasopressin receptor antagonists may have a role in treatment as well. Well-designed clinical trials are essential to guide therapy of refractory oedema in NS. In this review, the authors discuss the pathogenesis of oedema formation in patients with NS and propose a treatment algorithm for management of resistant oedema based on the limited available evidence.
Perbedaan Karakteristik Serta Tingkat Pelayanan Pejalan Kaki Pada Kawasan Pedestrian Di Kota Kendari (TPKPP)
Authors: Rahayu Sri Fera , Magribi Muh. , Harimudin Jamal , Fitriani Fitriani
Published: December 2021

Abstrak: Penelitian di kawasan perdagangan (Mall Mandonga) dan pendidikan (Universitas Halu Oleo) Penelitian ini telah dilaksanakan pada bulan Juli 2019 sampai Oktober 2019. Teknik pengumpulan data dilakukan dengan 1) survey melalui kuisioner dan wawancara terhadap responden 2) observasi pengamatan kegiatan fisik di lapangan 3) dokumentasi. Metode analisis data yang digunakan yaitu analisis karakteristik pejalan kaki, tingkat pelayanan jalan kaki dan tingkat kepuasan pejalan kaki kemudian dijelaskan secara deskriptif. Hasil penelitian menunjukkan bahwa tingkat pelayanan fasilitas pejalan kaki pada kawasan pendidikan di Universitas Halu Oleo adalah C dengan pejalan kaki memiliki arus stabil tetapi pejalan kaki dibatasi dalam memilih kecepatan dan sedikit ada konflik dengan tingkat pelayanan. Sedangkan tingkat pelayanan pejalan kaki pada kawasan perdagangan di Mall Mandonga adalah D dengan pejalan kaki memiliki arus mendekati tidak stabil sedangkan kecepatan masih bisa dikendalikan dan konflik yang terjadi di trotoar tersebut masih dapat ditolerir.. Kata Kunci : Karakteristik, Pejalan Kaki, Tingkat Pelayanan, Kawasan Pedestrian Abstrack: Research in the trade area (Mandonga Mall) and education (Halu Oleo University) This research was conducted in July 2019 to October 2019. Data collection techniques were carried out by 1) surveying through questionnaires and interviews with respondents 2) observing physical activity observations in the field 3) documentation. The data analysis method used is the analysis of pedestrian characteristics, the level of walking services and the level of pedestrian satisfaction then described descriptively. The results showed that the level of service of pedestrian facilities in the education area at Halu Oleo University is C with pedestrians having a steady flow but pedestrians are limited in choosing speed and there is little conflict with service levels. While the level of pedestrian services in the trade area at Mandonga Mall is D with pedestrians having an unstable approaching flow while speed can still be controlled and conflicts occurring on the sidewalk are still tolerable. Keywords: Characteristics, Pedestrians, Service Level, Pedestrian Region.
Analisis Pengembangan Kawasan Agropolitan Di Kecamatan Sinjai Barat
Authors: Hidayat Ahmad , Suratman Suratman , Hadmoko Danang Sri
Published: December 2021

Abstrak: Kecamatan Sinjai Barat adalah merupakan salah satu kecamatan yang ditetapkan sebagai kawasan agropolitan. Luas wilayah Kecamatan Sinjai Barat adalah 13,53 km2 atau 16,53% dari luas total wilayah Kabupaten Sinjai. Penelitian ini bertujuan : 1) mengidentifikasi jenis komoditas unggulan; 2) mengetahui kesesuaian lahan; 3) mengidentifikasi pola sebaran spasial pengembangan kawasan agropolitan. Metode penelitian adalah metode deskriptif berupa pengumpulan dan pengolahan data lapangan, metode pemetaan, metode Location Quotient (LQ), dan metode matching pada software atau program Land Classification and Landuse Planning (LCLP). Hasil penelitian ini menunjukkan bahwa : 1) hasil perhitungan LQ komoditas padi, ketimun, sawi, kentang, wortel, kubis, tomat, serta buncis merupakan komoditas unggulan. 2) kelas kesesuaian lahan, padi dengan kelas kesesuaian lahan S2 (cukup sesuai) 329,49 Ha, S3 (sesuai marginal) 2821,77 Ha, kentang, wortel, sawi, buncis, dan tomat memiliki kelas kesesuaian lahan S2 742,02 Ha dan untuk kelas kesesuaian lahan S3 2409,24 Ha. Komoditas lainnya yakni ketimun dan buncis memiliki kelas kesesuaian lahan S2 742,02 Ha, S3 2062,82 Ha serta kelas kesesuaian lahan N (tidak sesuai) 346,42 Ha. 3) adapun luas lahan yang dapat digunakan untuk pengembangan komoditas padi 329,49 Ha, kentang, wortel dan tomat 1276,59 Ha, ketimun dan sawi 412,53 Ha, buncis 519,47 Ha serta kubis 613,18 Ha. Kata Kunci : Agropolitan, Komoditas Unggulan, LCLP, Kesesuaian Lahan
Analisis Tingkat Kekumuhan Permukiman Pesisir Di Kecamatan Abeli
Authors: Asyfa Asyfa , Ido Irfan , Nurgiantoro Nurgiantoro
Published: December 2021

Abstrak: Penelitian  ini  bertujuan  untuk  menentukan  indeks  kekumuhan  permukiman  pesisir  dan menganalisis kondisi eksisting permukiman di Kecamatan Abeli Kota Kendari dengan menggunakan analisis deskriptif kuantitatif. Penelitian ini menggunakan metode overlay dengan memberikan penilaian pada setiap indikator kekumuhan yang telah ditetapkan oleh Dirjen Perumahan dan Permukiman seperti: kepadatan bangunan, kelayakan bangunan, aksesibilitas lingkungan, drainase lingkungan,  pelayanan  air  bersih,  pengelolaan  air  limbah  dan  pengelolaan  persampahan.  Hasil penelitian menunjukkan bahwa indeks kekumuhan permukiman pesisir di Kecamatan Abeli terdiri dari dua kelas yaitu kumuh sedang dan kumuh berat. Kelas kumuh sedang dengan indeks kekumuhan 2,5-3,4 terdapat di Kelurahan Pudai RT 02, Kelurahan Lapulu RT 01 dan 02, Kelurahan Poasia RT 03 dan 05, Kelurahan Talia RT 01. Kelas kumuh berat dengan indeks kekumuhan 3,5- 4,4 terdapat pada Kelurahan Pudai RT 01, Kelurahan Lapulu RT 03 dan Kelurahan Talia RT 02, 03 dan 04. kondisi eksisting untuk tingkat permukiman kumuh sedang memiliki kondisi lingkungan umumnya cenderung menengah, dimana terdapat beberapa aspek yang memiliki kesamaan dengan permukiman kumuh ringan. Kondisi kumuh berat kondidsi lingkungannya buruk, terdapat kecenderungan bahwa semakin buruk tingkat kekumuhan permukiman, maka semakin buruk pula kondisinya dengan memilki kondisi sarana dan prasarana yang tidak memadai dan kondisi lingkungan yang kurang terjaga. Kata Kunci:  permukiman kumuh, tingkat kekumuhan, overlay parameter Abstract: This study aims to determine the slum index of coastal settlements and analyze the existing conditions of settlements in Kendari City Abeli District using quantitative descriptive analysis. This study uses the overlay method by giving an assessment of each slum indicator set by the Director General of Housing and Settlements such as: building density, building feasibility, environmental accessibility, environmental drainage, clean water services, waste water management and waste management. The results showed that the slum index of coastal settlements in Abeli  Subdistrict consisted of two classes namely medium slums and heavy slums. Where moderate slum with 2.5-3.4 slum index found in Pudai Village RT 02, Lapulu Village RT 01 and 02, Poasia Village RT 03 and 05, Talia Village RT 01. For heavy slum classes with 3.5- slum index 4.4 is found in Pudai RT 01 Village, Lapulu Village RT 03 and Talia RT 02, 03 and 04 Village. With the existing conditions for slum settlements having moderate environmental conditions generally tend to be medium, where there are several aspects that have similarities with light slum settlements . While the condition of heavy slum conditions is poor, there is a tendency that the worse the slum level of settlements, the worse the condition is by having inadequate conditions of facilities and infrastructure and adverse environmental conditions. Keywords: slum settlement, slum level, parameter overlay
Pengaruh Pemberian Sari Kacang Hijau dan Tablet Tambah Darah terhadap Peningkatan Kadar Hemoglobin pada Remaja Putri
Authors: Usman Hastuti , Silfia Niluh Nita , Dewie Artika , Mariani Evi
Published: December 2021

Introduction: The incidence of anemia in women is 27.2% higher than men, 20.3%, mostly in the age group 15-24 years. The decrease in hemoglobin levels is caused by low intake of iron and other nutrients as well as the menstrual process. The coverage of giving blood tablets in Sigi Regency in 2019 was 81.25%. The purpose of this study was to determine the effect of giving green bean juice and blood-added tablets to increase hemoglobin levels in adolescent girls. Methods: Quasi-experimental research method with pretest-posttest control group design method. The population is young women aged 12 to 16 years with a total of 32 respondents. The research was conducted in the working area of ​​the Kinovaro Health Center. Results: The results of Hb levels in adolescent girls after being given the intervention of mung bean juice and added tablets are 2 g/dl with a p-value of 0.022, which means that there is a significant difference before and after giving green bean juice and blood-added tablets to the increase in hemoglobin levels of adolescent girls. Conclusion: Giving mung bean juice and blood-added tablets had a significant effect on increasing hemoglobin levels in adolescent girls. Suggestions are giving green beans and blood-added tablets once a week is very beneficial for young women in overcoming anemia.
Analisis Pelaksanaan Program Prolanis Di Puskesmas Rawat Inap Biha Kabupaten Pesisir Barat
Authors: Wedyarti Lena , Setiaji Bambang , Masra Ferizal
Published: December 2021

Hipertensi dan diabetes mellitus merupakan Penyakit Tidak Menular (PTM) yang paling banyak mendapat perhatian dunia. Hipertensi dan diabetes mellitus dijuluki sebagai silent killer karena sering muncul tanpa keluhan, akibatnya banyak penderita terlambat untuk mendapatkan penanganan yang memadai. Menurut Kemenkes RI tahun 2017 hanya 36,8% penderita hipertensi yang tercakup oleh tenaga kesehatan sementara penderita diabetes mellitus hanya 30,4%. (Kemenkes RI, 2017). Prolanis adalah suatu sistem pelayanan kesehatan dengan pendekatan proaktif yang dilaksanakan secara terintegrasi dengan melibatkan peserta, fasilitas kesehatan dan BPJS Kesehatan dalam rangka pemeliharaan kesehatan bagi peserta BPJS Kesehatan penderita penyakit kronis untuk meraih kualitas hidup yang optimal dengan biaya pelayanan kesehatan yang efektif dan efisien. Tujuan dalam penelitian untuk menganalisis pelaksanaan prolanis di Puskesmas Biha. Penelitian ini menggunakan metode kualitatif menggunakan metode pengumpulan data survey bersifat cross sectional dengan jenis rancangan deskriptif. Informan berjumlah 8 orang dan instrumen yaitu pedoman wawancara mendalam, daftar tilik observasi dan daftar tilik telaah dokumen. Hasil penelitian menunjukkan bahwa pelaksanaan prolanis masih belum maksimal, hal ini ditandai dengan pelaksanaan edukasi belum maksimal, masih banyak peserta yang kurang pengetahuan tentang penyakitnya. Saran kepada puskesmas agar petugas membuat jadwal pasti pelaksanaan edukasi tentang hipertensi dan dm serta membuat inovasi agar peserta dapat antusias mengikuti kegiatan tersebut.
Paparan Logam Plumbum (Pb) sebagai Pemicu Stunting pada Balita: Literature Review
Authors: Nurjazuli  , Darundiati Yusniar Hanani , Wardoyo Slamet
Published: December 2021

Stunting masih menjadi permasalahan kesehatan pada balita di seluruh dunia, terutama pada negar-negara berpenghasilan rendah. Faktor pemicu stunting di setiap negara masih terjadi kesengjanhan data dari factor gizi maupun factor sanitasi lingkungan. Namun ada kajian lanjut dari kontribusi paparan lingkungan beracun termasuk timbal dikaitkan dengan defisit nutria dan berujung stunting pada balita. Tinjauan literatur mengidentifikasi paparan logam berat terutama plumbum (Pb) sebagai factor stunting pada balita. Pencarian literatur dilakukan pada database elektronik PumMed, ProQuest, Google Scholar dengan kata kunci “(Stunt* or Growth), (Plumbum or Pb or Lead). Kriteria inklusi adalah Stunting or Growth and paparan Plumbum or Lead or Pb, Fulltext, diterbitkan 2016-2021, tipe artikel Randomized Controlled Trial and Clinical Trial. Kriteria eksklusi adalah Stunting yang disebabkan oleh asupan Gizi, artikel dalam bentuk Books and Documents, Meta-Analysis, Review dan Systematic Review.. Hasil kajian pustaka menunjukkan paparan logam berat berupa Pb pada balita yang bersumber dari lingkungan berdampak pada stunting pada balita karena sifat dari logam berat yang menghambat proses penyerapan nutrisi dari makanan dan berbanding lulus dengan penurunan skor Kognitif pada anak
The Healthy Indonesia Program and Family Role In Dealing with Covid-19 In Indonesia
Authors: Ismunandar Ismunandar , Hafid Fahmi , Taqwin Taqwin , Zainul Zainul , Junaidi Junaidi , Nasrul Nasrul
Published: December 2021

The Healthy Indonesia Program with a Family Approach (PIS-PK) aims to improve the quality of life of Indonesian citizens from the smallest unit of society, namely the family. This program is the family's main capital in dealing with the COVID-19 pandemic. The purpose of this study was to assess the potential of the Healthy Indonesia program and the role of families in dealing with Covid-19 in Indonesia. Literature review was conducted during 27 July 2021 to 07 August 2021, and literature search used Publish or Perish software for the time period of 2020-2021. Search keywords include: Coronavirus, Vaccines, Covid-19, Healthy Indonesia Program, Family Planning, delivery in health facilities, complete basic immunization, Exclusive Breastfeeding, growth monitoring, pulmonary tuberculosis, hypertension, mental disorders, smoking, National Health Insurance, access to clean water facilities and healthy latrines. Study findings showed that family planning services, delivery in health facilities, complete basic immunization, and growth monitoring could still be implemented by families in Indonesia. Likewise, the treatment of tuberculosis, hypertension, mental disorders is carried out on a limited basis. The behavior of exclusive breastfeeding, no smoking family members, families which have become members of the National Health Insurance and families which have access to clean water facilities are family capital in dealing with the covid-19 pandemic. In conclusion, the more complete the status of a healthy family based on 12 indicators, the more resilient each family will be in dealing the covid-19 pandemic.
Life Course Impact of Glucocorticoids During Pregnancy on Muscle Development and Function
Authors: Liu Yang , Ding Qiyue , Guo Wei
Published: December 2021

Maternal stress, such as maternal obesity, can induce severe gestational disease and hormonal disorder which may disrupt fetal organ maturation and further cause endangered early or future health in offspring. During fetal development, glucocorticoids are essential for the maturation of organ systems. For instance, in clinical applications, glucocorticoids are commonly utilized to pregnant women with the risk of preterm delivery to reduce mortality of the newborns. However, exposure of excessive glucocorticoids at embryonic and fetal developmental stages can cause diseases such as cardiovascular disease and muscle atrophy in adulthood. Effects of excessive glucocorticoids on human health are well-recognized and extensively studied. Nonetheless, effects of these hormones on farm animal growth and development, particularly on prenatal muscle development, and postnatal growth, did not attract much attention until the last decade. Here, we provided a short review of the recent progress relating to the effect of glucocorticoids on prenatal skeletal muscle development and postnatal muscle growth as well as heart muscle development and cardiovascular disease during life course.
Research Progress of Carrier-Free Antitumor Nanoparticles Based on Phytochemicals
Authors: Jiang Siliang , Fu Yu , Zhang Xinyang , Yu Tong , Lu Bowen , Du Juan
Published: December 2021

Cancer is a major worldwide public health issue, responsible for millions of deaths every year. Cancer cases and deaths are expected to increase rapidly with population growth, age, and lifestyle behaviors that increase cancer risk. Long-term chemotherapy results in acquired drug resistance. Traditional treatment methods have limitations and cannot effectively treat distal metastatic cancers. Application of nanocarriers in multi-chemotherapy must be promoted. With research progress, the shortcomings of traditional nanocarriers have gradually become evident. Carrier-free nanodrugs with desirable bioactivity have attracted considerable attention. In this review, we provide an overview of recent reports on several carrier-free nanodrug delivery systems based on phytochemicals. This review focuses on the advantages of carrier-free nanodrugs, and provides new insights for establishment of ideal cancer treatment nanosystems.
Upregulation of Fibrinogen-Like 1 Expression Contributes to Reducing the Progression of Preeclampsia
Authors: Cheng Tsung-Lin , Chen Chung-Hwan , Wu Meng-Hsing , Lai Chao-Han , Lee Ko-Hung , Lin Sheng-Hsiang , Shiau Ai-Li , Wu Chao-Liang , Kang Lin
Published: December 2021

Fibrinogen-like 1 (FGL1) is involved in liver injury and liver regeneration, but its role in placenta and preeclampsia (PE) remains unclear. We assessed FGL1 expression in serum and placenta from L-NAME-induced PE-like mouse and in women with (n = 38) and without (n = 42) PE. For the mouse study, pregnant C57Bl/6 mouse (n = 6/group) were subcutaneously administered L-NAME with or without FGL1 once daily starting on days 7–14 of pregnancy and were sacrificed on gestational day (GD) 20. Maternal body weight, blood pressure, and urinary protein were assessed during GDs 8–20. The weight and length of the placenta and fetus were assessed. The placental structure was evaluated using hematoxylin staining. In the human study, the sera of the pregnant women during the late trimester were assessed with enzyme-linked immunosorbent assays (ELISAs). FGL1 expression in human trophoblast cell lines under L-NAME stimulation was measured using Western blotting and immunofluorescence staining. The detected FGL1 protein levels in serum and placenta were both significantly upregulated in patients and mouse with PE compared with those in the non-PE groups. FGL1 treatment decreased maternal hypertension and proteinuria, decreased fetal weight in mouse with PE, downregulated proinflammatory cytokine (interleukin-1b and interleukin-6) levels, and maintained the balance between antiangiogenic (fms-like tyrosine kinase-1) and proangiogenic (placental growth factor) substances in the placenta. L-NAME-upregulated FGL1 expression was inhibited following overexpression of FoxO3a. In summary, FoxO3a reduction is a potential pathophysiological mechanism leading to upregulated placental FGL1 expression that may play a pivotal role in preventing PE progression.
Prognostic Nomograms Based on Ground Glass Opacity and Subtype of Lung Adenocarcinoma for Patients with Pathological Stage IA Lung Adenocarcinoma
Authors: Zhai Wenyu , Liang Dachuan , Duan Fangfang , Wong Wingshing , Yan Qihang , Gong Li , Lai Renchun , Dai Shuqin , Long Hao , Wang Junye
Published: December 2021

The value of lung adenocarcinoma (LUAD) subtypes and ground glass opacity (GGO) in pathological stage IA invasive adenocarcinoma (IAC) has been poorly understood, and reports of their association with each other have been limited. In the current study, we retrospectively reviewed 484 patients with pathological stage IA invasive adenocarcinoma (IAC) at Sun Yat-sen University Cancer Center from March 2011 to August 2018. Patients with at least 5% solid or micropapillary presence were categorized as high-risk subtypes. Independent indicators for disease-free survival (DFS) and overall survival (OS) were identified by multivariate Cox regression analysis. Based on these indicators, we developed prognostic nomograms of OS and DFS. The predictive performance of the two nomograms were assessed by calibration plots. A total of 412 patients were recognized as having the low-risk subtype, and 359 patients had a GGO. Patients with the low-risk subtype had a high rate of GGO nodules (p < 0.001). Multivariate Cox regression analysis showed that the high-risk subtype and GGO components were independent prognostic factors for OS (LUAD subtype: p = 0.002; HR 3.624; 95% CI 1.263–10.397; GGO component: p = 0.001; HR 3.186; 95% CI 1.155–8.792) and DFS (LUAD subtype: p = 0.001; HR 2.284; 95% CI 1.448–5.509; GGO component: p = 0.003; HR 1.877; 95% CI 1.013–3.476). The C-indices of the nomogram based on the LUAD subtype and GGO components to predict OS and DFS were 0.866 (95% CI 0.841–0.891) and 0.667 (95% CI 0.586–0.748), respectively. Therefore, the high-risk subtype and GGO components were potential prognostic biomarkers for patients with stage IA IAC, and prognostic models based on these indicators showed good predictive performance and satisfactory agreement between observational and predicted survival.
TiO2 Hollow Spheres With Flower-Like SnO2 Shell as Anodes for Lithium-Ion Batteries
Authors: Weng Ying , Zhang Ziying , Zhang Huizhen , Zhou Yangyang , Zhao Xiaona , Xu Xingran
Published: December 2021

SnO2 is a promising anode material for lithium-ion batteries due to its high theoretical specific capacity and low operation voltage. However, its poor cycling performance hinders its commercial application. In order to improve the cycling stability of SnO2 electrodes, novel flower-like SnO2/TiO2 hollow spheres were prepared by facile hydrothermal method using carbon spheres as templates. Their flower-like shell and mesoporous structure highlighted a large specific surface area and excellent ion migration performance. Their TiO2 hollow sphere matrix and 2D SnO2 nano-flakes ensured good cycle stability. The electrochemical measurements indicated that novel flower-like SnO2/TiO2 hollow spheres delivered a high specific capacity, low irreversible capacity loss and superior rate performance. After 1,000 cycles at current densities of 200 mA g−1, the capacity of the flower-like SnO2/TiO2 hollow spheres was still maintained at 720 mAh g−1. Their rate capacity reached 486 mAh g−1 when the current densities gradually increase to 2,000 mA g−1.
Mini Review: Quantum Confinement of Atomic and Molecular Clusters in Carbon Nanotubes
Authors: de Lara-Castells María Pilar , Mitrushchenkov Alexander O.
Published: December 2021

We overview our recent developments on a computational approach addressing quantum confinement of light atomic and molecular clusters (made of atomic helium and molecular hydrogen) in carbon nanotubes. We outline a multi-scale first-principles approach, based on density functional theory (DFT)-based symmetry-adapted perturbation theory, allowing an accurate characterization of the dispersion-dominated particle–nanotube interaction. Next, we describe a wave-function-based method, allowing rigorous fully coupled quantum calculations of the pseudo-nuclear bound states. The approach is illustrated by showing the transition from molecular aggregation to quasi-one-dimensional condensed matter systems of molecular deuterium and hydrogen as well as atomic 4He, as case studies. Finally, we present a perspective on future-oriented mixed approaches combining, e.g., orbital-free helium density functional theory (He-DFT), machine-learning parameterizations, with wave-function-based descriptions.
Plasmodium falciparum and Plasmodium vivax Adjust Investment in Transmission in Response to Change in Transmission Intensity: A Review of the Current State of Research
Authors: Oduma Colins O. , Koepfli Cristian
Published: December 2021

Malaria parasites can adjust the proportion of parasites that develop into gametocytes, and thus the probability for human-to-vector transmission, through changes in the gametocyte conversion rate. Understanding the factors that impact the commitment of malaria parasites to transmission is required to design better control interventions. Plasmodium spp. persist across countries with vast differences in transmission intensities, and in sites where transmission is highly seasonal. Mounting evidence shows that Plasmodium spp. adjusts the investment in transmission according to seasonality of vector abundance, and transmission intensity. Various techniques to determine the investment in transmission are available, i.e., short-term culture, where the conversion rate can be measured most directly, genome and transcriptome studies, quantification of mature gametocytes, and mosquito feeding assays. In sites with seasonal transmission, the proportion of gametocytes, their densities and infectivity are higher during the wet season, when vectors are plentiful. When countries with pronounced differences in transmission intensity were compared, the investment in transmission was higher when transmission was low, thus maximizing the parasite’s chances to be transmitted to mosquitoes. Increased transmissibility of residual infections after a successful reduction of malaria transmission levels need to be considered when designing intervention measures.
The Evidence Chamber: Playful Science Communication and Research Through Digital Storytelling
Authors: Doran Heather , Barnard Dan , McAlister Joe , Briscoe Rachel , Hackman Lucina , Nic Daeid Niamh
Published: December 2021

In a courtroom, it is essential that the scientific evidence is both understandable and understood, so that the strengths and limitations of that evidence, within the context of a legal case, can inform decision making. The Evidence Chamber brings together entertainment, public engagement with science and research into a public performance activity that is centred around digital storytelling and science communication. This experience engages public audiences with science and allows a better understanding of how people interpret scientific evidence. In this paper, we discuss how we created this experience as an in-person and fully virtual performance through successful collaboration between forensic science research, public audiences, public engagement professionals, the legal profession, and digital performance artists.
Circulating Interleukin-7 in Human Pulmonary Arterial Hypertension
Authors: Diekmann Franziska , Legchenko Ekaterina , Chouvarine Philippe , Lichtinghagen Ralf , Bertram Harald , Happel Christoph M. , Hansmann Georg
Published: December 2021

Objectives: Interleukin-7 (IL-7) secures B cell maturation, regulatory T and natural killer (NK) cell survival, and homeostasis, all of which are important for beneficial immunomodulation in pulmonary arterial hypertension (PAH). However, the role and potential impact of IL-7, VEGF-C and the vascular injury markers ICAM-1, and VCAM-1 on the pathobiology and severity of PAH is unknown.

Methods: EDTA blood was collected during cardiac catheterization from the superior vena cava (SVC), pulmonary artery (PA), and ascending aorta (AAO) in children with pulmonary hypertension (PH) [n = 10; 9.1 (3.9–18.5) years] and non-PH controls [n = 10; 10.5 (2.0–17.3) years]. Compartment-specific plasma concentrations of IL-7, VEGF-C, aldosterone, ICAM-1, and VCAM-1 were determined using Meso Scale Discovery's multi array technology and the LIAISON Aldosterone Assay.

Results: Children with PH had approximately 50% lower IL-7 (p < 0.01) and 59% lower VEGF-C plasma levels (p < 0.001) in the SVC, PA, and AAO versus non-PH controls. IL-7 and VEGF-C concentrations negatively correlated with the pulmonary vascular resistance (PVR)/systemic vascular resistance (SVR) ratio (rho = −0.51 and r = −0.62, respectively). Central-venous IL-7 strongly positively correlated with VEGF-C (r = 0.81). Most patients had a step down in ICAM-1 and VCAM-1 plasma concentrations across the pulmonary circulation and both ICAM-1 and VCAM-1 transpulmonary gradients negatively correlated with invasive hemodynamics.

Conclusion: This manuscript is the first report on decreased circulating IL-7 and VEGF-C plasma concentrations in human PAH and their inverse correlations with invasive surrogates of PAH severity. Additional and larger studies are needed to explore the role of the immune-modulatory IL-7 and VEGF-C in pediatric and adult PAH.
Research on a New Single-End Fault Location Method for Single-Phase Grounding Faults of Transmission Lines Through Transition Resistance
Authors: Li Botong , Shi Lin , Wen Weijie , Li Bin , Chen Xiaolong , Su Jiang
Published: December 2021

A single-end fault location method for single-phase nonmetallic grounding faults of transmission lines in a double terminal system is studied and proposed. First, the reason for the poor accuracy of the single-end fault location method in case of single-phase nonmetallic grounding faults is analyzed theoretically, and the necessary conditions for the single-end accurate fault location are put forward. Second, under the necessary conditions of the single-end accurate fault location, according to the topology of fault component networks, the calculation method of the single-end accurate fault location of transmission lines in a double terminal system is studied. Moreover, the influence of line capacitance is considered in this fault location method, and a simple expression for calculating the fault distance is obtained. Finally, the transmission line with a single-phase nonmetallic grounding fault is modeled in PSCAD; therefore, the correctness and the ability against transition resistance of the new single-end fault location method are verified by simulation.
How Does the Consumers’ Attention Affect the Sale Volumes of New Energy Vehicles: Evidence From China’s Market
Authors: Jiang Zhe , Long Yin , Zhang Lingling
Published: December 2021

The promotion of new energy vehicles is a grand plan across countries to achieve carbon neutrality and air purification. The sale volume of new energy vehicles is affected by many factors, yet it is the attitude of consumers themselves that has the final decisive role. We use four representative Baidu search indexes as the variables representing the attention of consumers and take variables of economic, population, and income as control variables for regression analysis from the national and sub-economic regional perspectives respectively. Results show that search indexes of “new energy vehiclek.” “new energy vehicles battery”, and ‘charging pile’ all have significant positive impacts on the sales of new energy vehicles to varying degrees while the index of ‘automobile spontaneous combustion’ has a significant negative impact on the sale volume. This study, therefore, verifies that the consumer attention represented by search indexes is an important yet uncovered factor affecting the sale volume of new energy vehicles. Besides, due to people’s prejudice against spontaneous combustion accidents of new energy vehicles, consumers have a cognitive bias about the spontaneous combustion rate of new energy vehicles especially in less developed areas of China.