bluuebunny/crossref_metadata_2025 huggingface dataset:
Scientific views of R.O. Jacobson in the paradigm of text-linguistics
Authors: Ye Lin , Liu Yitong
Published: November 2023

The semiotic concept of R.O. Jacobson has been studied, the ideas of which are associated with structuralism as a method of cognition, semiotics as the science of sign systems and poetics as the general semiotics of the text. We analyzed the main components of the R.O. Jacobson concept, which based on the linguocultural aspect of textual criticism. His complex and dialogical view of semiotics and the unique features of his research paradigm are summarized. When considering the category “complexity”, attention is drawn to the modeling of the “meaning – text” model in the aspect of bringing the science of language closer to the sciences of the anthropocentric cycle. Consideration of the similarity and contiguity of metaphor and metonymy allowed R.O. Jacobson should consider that any metonymy is endowed with a slight metaphorical shadow, and any metaphor has a metonymic coloring, and highlight a formal method of research, which represents the merging and transformation of two different processes of thinking – humanistic and scientific. The scientist considered linguistic consciousness to be in some way derivative of ethnocultural consciousness. since it clearly reflects the ideas of Eastern and Western people about the world within a separate national-cultural tradition, building its own scientific view, defining the features of the organization of discourse. The category of “dialogicity,” which manifests itself in the process of an individual’s speech-mental activity, realizes the dialectical unity of language and thinking, and therefore, bearing in mind the thought processes occurring in the human mind, it is more correct to speak of dialogicity as a text-generating speech-thinking process.
About the process of lexical dearhaization
Authors: Kharchenko Maria M.
Published: November 2023

The process of lexical dearhaization in the modern Russian language is considered, as a result of which words “return” to the active vocabulary from the passive stock of the language and take on a new life. Throughout the history and development of a language, the process of archaization is inevitable. Nowadays, this process has become especially relevant. It has been proven that the development of the process of dearhaization, as well as the previous lexical archaization, is facilitated by extra-linguistic factors, primarily ideological, social, as well as historical events that occurred at the turn of the 20th and 21st centuries. Changes in the political system, social system, economic and cultural life, the emergence of new ideas and activities have entailed both qualitative and quantitative changes in the modern lexical fund of the Russian language, as a result of which dearchaized words have become a vivid reflection of changes in public consciousness. It has been established that dearchaisms can be rethought and their meanings can be modified. The returned words reflect a certain layer of the spiritual cultural tradition and consciousness of the Russian people and are neutral lexical units in the modern linguistic communicative space.
Types of formal variants of words in the lexical system of Don patois of the Volgograd region
Authors: Filatova Irina M.
Published: November 2023

Don patois – with all the originality of linguistic features - are an organic part of the Russian dialect space. The studied patois are socially isolated, which determines such an inherent linguocultural phenomenon as prestige, therefore the Don patois retains the most important features of the traditional system. Studying the problem of variability allows us to trace the formation of the linguocultural space that forms the vocabulary of the Don patois, and to assess the current state of the lexical system of the studied dialects. Based on the material of Don Cossack patois, the question of the functioning of formal variants of a word in the dialect lexical system is considered. The formal intra-system dialect variation, covering variants of the word-formation level, has been analyzed. A brief overview of currently available points of view regarding the understanding of variability in the domestic linguistic tradition is presented. Criteria have been identified for distinguishing synonyms and variants in the lexical system of the Don patois. The collected material made it possible to trace the peculiarity of the dialect lexical system, which consists in the development of a large number of word variants. The study showed that word variants in Don patois are an integral part of the dialect lexical system, contributing to its preservation. The study of formal variability allows us to show the state of the lexical system of Russian patois at the present stage.
The role of numerals in the formation and functioning of the toponymic system: complex approach
Authors: Urazmetova Alexandra V.
Published: November 2023

The aim of the research is to conduct a comprehensive analysis of numerative toponyms on the material of the USA toponymic system. The material of the research was toponyms containing numerals from 1 to 10 in the amount of 20709 units, obtained by the method of continuous sampling from the USa toponymic database. The numerals transition process into the category of toponymic lexicon is investigated. The structural models of toponyms with numerals, the most frequent forms of writing numerals, as well as the most productive numerals on the map of the USA are revealed. The main numerals functions in the toponyms composition are determined. The percentage ratio of the studied units depending on the type of the designated object is revealed, which shows the preferable occurrence of numerals in the natural objects names composition, mainly hydronyms. The states of the USA with the largest and the smallest numeralized toponyms were identified. The prevalence of numerative toponyms on the territory of the USA is analyzed and the results are presented on the map. The numerative toponyms share in the USA toponymic lexicon is determined. The research makes a significant contribution to the toponym creation process knowledge, the role that numerals play in this process, and the peculiarities of their semantics and functioning. The research can be a starting point and a tool for further research in the field of toponymic naming, helping better understand and explain the place name formation cognitive mechanisms.
Folkloric characters in toponyms of Scotland: linguocognitive aspect
Authors: Pentsova Maria M.
Published: November 2023

The article is devoted to the study of Scottish toponyms with names of folklore characters. The purpose of the research is to establish what knowledge about folklore characters is reflected in Scottish toponymy, and what nomination mechanisms are involved in their development. The article deals with Scottish toponyms containing the names of geographical objects, and names of folklore characters. The source of empirical material is Scottish toponymic dictionaries, works of foreign researchers and Internet resources. The methods of searching for particular toponymic units, cognitive matrix, lexico-semantic and etymological analysis, as well as cultural analysis are used to accomplish the purpose. in the course of the research we considered toponyms, the internal form of which contains the names of giants Saxa and Herman and the names of mythical creatures – faeries, boggles and brownies. In the cognitive bases of the considered toponyms there is cognitive context folklore characters and characteristics of the concept of place: inhabitant, quality and event. The place-names are formed through metaphorical and metonymic transfers. the cognitive bases of the considered toponyms reflect such knowledge about folklore characters as their habitat, abilities of folklore characters and related actions and events occurring at the place. Metaphorical and metonymic transfers are based on the comparison of knowledge about the external properties of the character and the geographical object and knowledge about feelings caused by what happens at the object, as well as on the correlation of the name of the folklore character, the quality of the object acquired due to the folklore character, and the name of the object.
Compositional and graphic model of the literary and artistic magazine “Don”
Authors: Klemenova Elena N. , Mukha Angela V.
Published: November 2023

The study examined changes in the compositional and graphic model of the Don magazine. Various definitions of the term “compositional-graphic model” were also analyzed, on the basis of which the authors determined that this is a publication model, a kind of regulatory system that reflects the essential characteristics of the appearance of a periodical. The work identifies criteria for analyzing the compositional and graphic model of a literary and artistic magazine: 1) brand and logo; 2) cover design model; 3) original design of materials on the strips; 4) font design of headings, headings and texts; 5) additional means of selection; 6) color scheme of the publication. Based on the selected characteristics, an analysis was carried out of the design model of the magazine “Don” in the period from 1945 to 2022. The transformation of the compositional and graphic model of the literary and art magazine “Don” was analyzed. To achieve this goal, compositional and graphic models of the publication were considered in different periods of the existence of the Don magazine: 1945–1949, 1950–1952, 1953–1957, 1958–1963, 1963–1976, 1977–1979, 1980–1989, 1990–1993, 1994–2000, 2001–2022 At the final stage of the study, the modern compositional and graphic model of the publication was considered, which, according to the researchers, does not contribute to the recognition of the Don brand. During the study, the authors came to the conclusion that modern issues of the magazine lack an original design concept that could attract a new audience.
Methods of manipulating public opinion when covering political events by Russian and German’s radio stations
Authors: Bakanov Roman P. , Nurutdinova Kamilla A.
Published: November 2023

The research is devoted to the identification and study of methods of manipulating public opinion when covering political events by radio stations in Russia and Germany. Obtaining accurate and verified information about the events of reality is the constitutional right of every person, and the formation of an objective picture of the world and the explanation of the phenomena occurring is the most important function of the editorial office of each media. However, at present, the priority of the media is the formation (often imposition) of a certain public opinion that can distort the real situation both in the local and international context. 842 broadcasts of radio stations of different forms of ownership of Russia and Germany (three from each country) for the period from 17.01.2021 to 01.11.2022 were studied. On the example of four widely publicized Russian media events of a political nature, using the methods of content, plot-composition, lexico-stylistic and comparative analysis of radio broadcasts revealed the use of certain (even identical) manipulative techniques on both Russian and German radio stations. The leader in the regularity of the use of manipulative techniques was the state radio station “Vesti FM” (Russia) and “Deutschlandradio” (Germany), while correspondents of other radio stations studied by us presented information about events of interest to us on the air, as a rule, briefly, discreetly and only in a news format. The practice of regular use of manipulative techniques does not allow us to speak about the objective presentation of selected political media events by correspondents of some Russian and German radio stations. It seems that the current situation could contribute to the creation of an incomplete picture of the world among the audience of these radio stations. A conclusion has been reached that it is possible to minimize such cases only by continuing the activity of forming and developing a person’s critical thinking.
Screen communication in the context of the video essay genre
Authors: Mashaev Malaik S.-M. , Bazanova Anna E.
Published: November 2023

We studied the meaning of the screen as an intermediary between the author of a visual essay and his audience in the modern online space. The origins and features of the genre, which originated from the printed essay, are analyzed. We consider the types of videos, as well as the verbal and non-verbal methods used in them to convey information to the viewer. It has been established that the widespread use of the global network and multimedia technologies opens up opportunities for content creators to increase the user base and increase its involvement. New ways of designing broadcast information messages are emerging. The advent of electronic devices is facilitating the discovery of new ways of presenting information and interacting with audiences that were not previously possible in the traditional printed genres of film criticism. Modern software and technologies allow a wide range of authors to use editing as an effective method for explaining the thesis chosen for their work. Visual images have acquired a dominant role in presenting material. Social networks and comment sections on popular video hosting sites allow you to receive feedback from viewers, and also create a previously impossible connection between a film critic and his audience. The results of the study can be used by scientists in the field of mass communication, journalism and film criticism.
“Soft power” of the Russian language: cultural aspect
Authors: Pronina Lyudmila A. , Shcherbak Antonina S.
Published: November 2023

The concept of “soft power” of the Russian language is considered within the framework of the ethnocultural approach, it is proved that the language is aimed at expressing precisely national cultural affiliation, the specific unique environment of the culture, and the cultural dominants of the ethnic group. It is substantiated that the approach to the Russian language as the “soft power” of the state contributes to the development of “cultural” diplomacy. Five functions have been established that the Russian language performs in relation to culture, which allows us to consider the Russian language as the “soft power” of the state (communicative, integration, socializing, translational and cognitive functions). From different points of view, the concept of “Russian World” was analyzed and its basic constructs were identified – the Russian language and the Russian culture based on it (speech forms of explication of recognition of mentality, values, traditions, customs, etc.). Defining the basis of the soft power of the Russian language is attractiveness, the purpose of which is to unite (integrate) citizens of the Russian Federation, compatriots abroad and all those who feel mental and spiritual closeness with Russians. The inadequacy of using the potential of library institutions and the library community to promote the Russian language and expand the space for its use has been proven. Approaches to solving problems of state cultural policy in the sphere of the Russian language are described and proposed.
Multiparametric ultrasound in thyroid nodules evaluation: risk-stratification (review of literature)
Authors: Solovov V. A. , Ablekova O. N.
Published: November 2023

Ultrasound (US) is the first imaging modality for thyroid parenchyma evaluation. In the last decades, the role of ultrasound has been improved with the introduction of new US software, such as contrast-enhanced ultrasound and US-elastography. US-elastography is nowadays recognized as an essential part of the multiparametric ultrasound examination. More controversial is the role of contrast-enhanced ultrasound in thyroid evaluation, due to its high variability in sensitivity and specificity. We have therefore drawn up an updated representation of the current evidence in the literature for thyroid nodule multiparametric ultrasound evaluation with particular regard to US-elastography and contrast-enhanced ultrasound.
The Piety and Aspirations of Education Muslim Middle Class in Yogyakarta
Authors: Alam Lukis
Published: November 2023

Elite Islamic schools have recently become the alternative of the urban Muslim middle class. Its presence has raised alternative educational options in addition to madrassa and pesantren. As a student city and a fertile ground for investment, Yogyakarta is an excellent place for private schools to establish to accommodate the middle ups’, including Muslim families, needs. Using a qualitative approach, the study obtains data from both literature and field work and was held in Yogyakarta from March 2017 to December 2018. This research shows that the idea of elite Islamic schools in Yogyakarta was backgrounded by the eagerness to provide qualified Islamic education without neglecting the government’s policy on it. Characterized as a non-partisan Islamic school in Yogyakarta, Al-Azhar is a modern Islamic school that vocalizes moderate Islamic belief with no specific ideological affiliation. Budi Mulia Dua presents Islamic education emphasizing egalitarianism, inclusivity, and introduces Islamic values substantively without ignoring person-to-person relationships.
Inclusive Learning for Digital Natives in Sunan Kalijaga State Islamic University Yogyakarta
Authors: Nofiaturrahmah Fifi , Rahmawati Ulfah
Published: November 2023

Since inclusive education is required to develop learning innovations for students with disabilities and special education, it is driven by the equal rights of individuals to pursue higher education. This study thus aims to analyze implemented inclusive learning of students with disabilities at UIN Sunan Kalijaga Yogyakarta. The study of this theme was carried out using a qualitative approach. Data were collected by observation, interviews, and document analysis. All data were then analyzed in stages: reducing the data, presenting the data, and concluding the research results. Through triangulation (multiple sources and methods), the data validity was checked. The study results uncovered that 1) lecturers must design a curriculum that accommodates and suits all students, including students with disabilities. 2) Lecturers must support PLD (Center for Disability Service) by digitizing teaching materials, being actively involved in mid-semester FGDs, collaborating with PLD volunteers to achieve learning goals, and preparing adaptive learning evaluations according to the type of disability.
+ or –. A Process-Oriented Guided Inquiry Learning (POGIL) in Design Education Using Semiotics as a Tool
Authors: Nambissan Aditya
Published: November 2023

This article takes its name from a semester 6 architectural design studio developed using semiotics as an approach to develop a design methodology / design thinking process. This involves exploring different interpretations of the symbols + and −, and their various applications to the field of architecture and design. We try to analyse, trace the course of problems/issues, and interpret ideas of subtractive processes (inf luenced by economic, cultural, and technological changes) involved in extracting resources from mother earth; and thereafter, the impacts of additive processes in the act of building and constructing. With the design project situated in the rich timber industrial heritage of the North Malabar region of Calicut, Kerala (India), this material is a crucial element associated with memories. The absorption of the relational aspects of timber in this region’s cultural semiotics has led to interesting shifting in the built and unbuilt environments over the years. This has become the core inquiry of students’ engagement in decoding signs and symbols through the mediums of photography, diagramming, and hybrid representation. These in turn inform them how to intervene using design and create an architectural project based on these findings.
Stone Pipe and Metal Container: Design Semiotic Analysis of Sacral Objects
Authors: Újvári Edit
Published: November 2023

Design or the designer’s activity is not only designing an object, but also a complex mode of socialcultural relations and environmental situations. This paper focuses on the semiotic analysis of two historical examples where László Moholy-Nagy’s views ([1946] 1971)—which I interpret as “form adjusting itself to society”—are perfectly applicable. One object included in the design semiotic analysis is a Lakota ceremonial pipe, and the other is a sacral object of European Medieval culture, the Sainte-Foy reliquary of Conques. In both cases, the analysis is centred around formal and functional elements and materials that are impregnated with meaning. I intend to explain how, as sign vehicles (signifiers), the shape, ornamental elements, and materials of sacral objects, represent meanings and content. How is the form of these objects related to their function?
Ágnes Kapitány and Gábor Kapitány: A szimbolizáció. Hogyan cselekszünk szimbólumokkal?
Authors: Bodó Julianna , Biró A. Zoltán
Published: November 2023

Ágnes Kapitány and Gábor Kapitány: A szimbolizáció. Hogyan cselekszünk szimbólumokkal? Budapest: Ventus Commerce, 2021, 508 pages. ISBN-13: 978-6-155-82823-2
Klaus Krippendorff (1932–2022)
Authors: Bock Mary Angela
Published: November 2023

On October 10, 2022, my mentor and friend, Klaus Krippendorff died at the age of ninety. Dr. Krippendorff was the Gregory Bateson Professor Emeritus of Communication. He spent fifty-eight years on the faculty of the University of Pennsylvania’s Annenberg School for Communication, the longest-tenured faculty member in the history of the school.
Designing the Dream Ballet: From Oklahoma!’s Third Auteur to Fish’s Revival and Beyond
Authors: Park Maressa
Published: November 2023

Rodgers and Hammerstein’s epoch-defining, twice-Pulitzer Prize-winning Oklahoma! is wellknown for its integrated non-musical elements, which seamlessly create multimedia cohesion. The most iconic element of this integrated musical is Agnes de Mille’s “Dream Ballet”, a showstopping choreography and “microcosm” of the show’s plot and the paragon of its namesake genre. The Dream Ballet has undergone a striking evolution in the 2019 Oklahoma! revival at the Circle in the Square Theatre, noted for its subversion of the genre’s expectations. Although choreographer John Heginbotham and director Daniel Fish changed several aspects—including choreography, staging choices, audience immersion, and musical alterations—their refashioning of the Dream Ballet ushered in a new perspective and effect that is vital to the revival’s meaning and success at large. This paper examines the ways in which the two Dream Ballets design themselves around and challenge their respective political environments. Whereas de Mille removes and confine’s Oklahoma!’ s unmistakable original horror material, Heginbotham’s Dream Ballet capitalises on the immersion of the audience in a staging of communal sacrifice that plays upon its juxtaposition of community and belonging with community and culpability. Finally, this paper will examine the possibility of using virtual reality to emulate the specific affordances of the 2019 staging.
"Fabrica" and "Ratiocinatio". Introductory Notes on Design and Semiotics
Authors: Szentpéteri Márton
Published: November 2023

Although Vitruvius’ De architectura libri decem is generally regarded as the most ancient remaining piece of some sort of architectural theory, it is better to think of it as a book devoted to ancient design culture mutatis mutandis. We can do this retrofitting or intended retrospective anachronism with good conscience since a book on architectura written more than two thousand years ago can hardly be described as an example of the theory of architecture, since the concept did not exist at the time. A quick look at Vitruvius’ masterpiece brings to attention, for example, that its tenth book is on architectura organica, which has naturally nothing to do with the mod-ern style and phenomena of organic architecture, but with the design and building of machines, tools, and instruments (that is, organa). Etymologically speaking, architectus (or its Greek equivalent, architektōn) means someone who designs and creates the principal structures of any designed environment. In order to do so, one applies fabrica and ratiocinatio at the very same time. On the one hand, therefore, the architectus is well versed in craf ting basic structures, but he is equally capable of inventing, imagining, or designing these environments, objects, tools, and instruments, as well as clearly explaining and instructively interpreting their structure and executing process. Hence, according to Vitruvius, a designer who strives only to manual prac-tice without written culture (sine litteris) cannot be successful at all.
Semiosic Processes and Design Processes. Inventiveness, Dialogue, Narrativity, Translation
Authors: Zingale Salvatore
Published: November 2023

Design semiotics could lead to two lines of research: the study of design products and the study of design processes. As much as the analysis of artifacts has significance, the survey about semiosic processes inside design processes is the one that defines the unique nature of semiotics in the design context. This investigation follows “the pragmatist route” to design semiotics, for two reasons: (1) because it understands design as an activity that leverages the concept of inventive abduction and can provide answers to cognitive challenges; (2) because the work of design is never to be conceived as concluded in the final result, but embedded in a f low of unlimited semiosis. I will focus on the concept of semiosis according to Peirce’s semiotics, understood as a process of production of sense. In this way, I will deal with the following four processes: Inventiveness, whose logical model refers to abduction, the process that enables exploration of the ways to possible meanings. Based on Bakhtin’s literary theory and Bohm’s epistemology, dialogicity, which will be considered as the social interaction model underpinning every social idea of design. Narrativity, understood as the general scheme that is implemented in a project, understood as a series of actions leading to the achievement of a goal, and as a process of transformation. Translation, considered not only as an interpretation process that takes place between different forms of expression, but especially as a transition from a problem or desire to an “interpretant artifact.”
Isotopic evidence for nickel limitation of biological productivity in the ocean
Authors: Wang Tzu-Hao , Zhang Qiong , Hsieh Tu-Te , Henderson Gideon , Rickaby Rosalind
Published: November 2023

Nickel (Ni) is an essential element for many important enzyme systems1,2. Two puzzling aspects of Ni biogeochemical cycling in the modern ocean have emerged. First, unlike a number of bio-essential elements, Ni is never fully depleted in the surface ocean3-13. Second, a heavy Ni isotopic composition in the surface ocean, indicative of removal of light isotopes likely by productivity, is not observed globally6-13. Active debate persists regarding the isotopic fractionation of Ni associated with biological uptake and the bioavailability of Ni in the ocean7,9,11-13. Here we show that, in contrast to biological isotopic fractionation for most other elements, three cosmopolitan phytoplankton species preferentially take up isotopically heavy Ni from the culture media, with species-dependent magnitudes of fractionation, under varying Ni availability. This fractionation towards heavy Ni isotopes can be explained, in our experiments, by the characteristic strong Ni-binding of cellular metal acquisition systems, relative to weaker binding by ligands in the culture media, with a secondary influence of cellular relocation and/or efflux. In the open ocean, an inferred stronger binding of Ni to ligands present in seawater, relative to that of the phytoplankton, yields the inverse fractionation (towards light isotopes in the biomass) and limits the bioavailability of metals in the surface ocean. Reconciling seawater Ni concentration and isotope data, results from incubation experiments, and marine gene biogeography, we demonstrate that Ni is limited for marine phytoplankton in the mid-latitude surface ocean with low Ni concentration and heavy Ni isotope composition, with implications for the significance of Ni bioavailability on both ocean productivity and carbon cycling.
Developing innovative Filtration Membranes based on SiO2/TiO2/Cdot(N) for wastewater treatment.
Authors: Name Luccas L , Tiba Daniel Y , Canevari thiago C
Published: November 2023

This work describes a new, cost-effective modified filtration membrane for wastewater treatment containing different substances. The filtration membrane comprises a nylon substrate modified by SiO2/TiO2/Cdot(N) nanostructures in situ. SiO2/TiO2/Cdot(N) nanostructures have been prepared using nitrogen-doped carbon quantum dots (Cdot(N)), electrochemically synthesized by oleylamine, which was also applied as reaction catalysts between titanium isopropoxide and silica source. FTIR, Raman spectroscopy, SEM, EDS, and HR-TEM characterized SiO2/TiO2/Cdot(N) nanostructures. The membrane operated as a rapid filtration tool and presented good sorbent capacity, 10 mg of methylene blue, 4.2 mg of methyl orange, and 17.3 mg of bisphenol A per gram of sorbent obtained by standard addition method. The waste removal capacities were calculated using UV spectroscopy at 275, 464, and 664 nm wavelengths. The filtration membrane composed of a nylon membrane substrate modified by SiO2/TiO2/Cdot(N) nanostructures presents an excellent performance in retaining this substance in a real water sample.
The prognostic value of tumor-stroma ratio and a newly developed computer-aided quantitative analysis of routine H&E slides in high-grade serous ovarian cancer
Authors: wagensveld lilian van , Walker Cedric , Hahn Kerstin , Sanders Joyce , Kruitwagen Roy , Aa Maaike van der , Sonke Gabe , Rottenberg Sven , de Vijver Koen Van , Janowczyk Andrew , Horlings Hugo
Published: November 2023

Introduction: Tumor-stroma ratio (TSR) is prognostic in multiple cancers, while its role in high-grade serous ovarian cancer (HGSOC) remains unclear. Despite the prognostic insight gained from genetic profiles and tumor-infiltrating lymphocytes (TILs), the prognostic use of histology slides remains limited, while it enables the identification of tumor characteristics via computational pathology reducing scoring time and costs. To address this, this study aimed to assess TSR's prognostic role in HGSOC and its association with TILs. We additionally developed an algorithm, Ovarian-TSR (OTSR), using deep learning for TSR scoring, comparing it to manual scoring. Methods: 340 patients with advanced-stage who underwent primary debulking surgery (PDS) or neo-adjuvant chemotherapy (NACT) with interval debulking (IDS). TSR was assessed in both the most invasive (MI) and whole tumor (WT) regions through manual scoring by pathologists and quantification using OTSR. Patients were categorized as stroma-rich (≥ 50% stroma) or stroma-poor (< 50%). TILs were evaluated via immunohistochemical staining. Results: In PDS, stroma-rich tumors were significantly associated with a more frequent papillary growth pattern (60% vs 34%), while In NACT stroma-rich tumors had a lower Tumor Regression Grading (TRG 4&5, 21% vs 57%) and increased pleural metastasis (25% vs 16%). Stroma-rich patients had significantly shorter overall and progression-free survival compared to stroma-poor (31 versus 45 months; P < 0.0001, and 15 versus 17 months; P = 0.0008, respectively). Combining stromal percentage and TILs led to three distinct survival groups with good (stroma-poor, high TIL), medium (stroma-rich, high TIL, or; stroma-poor, Low TIL), and poor(stroma-rich, low TIL) survival. These survival groups remained significant in CD8 and CD103 in multivariable analysis (Hazard ratio (HR) = 1.42, 95% Confidence-interval (CI) = 1.02–1.99; HR = 1.49, 95% CI = 1.01–2.18, and HR = 1.48, 95% CI = 1.05–2.08; HR = 2.24, 95% CI = 1.55–3.23, respectively). OTSR was able to recapitulate these results and demonstrated high concordance with expert pathologists (correlation = 0.83). Conclusions: TSR is an independent prognostic factor for survival assessment in HGSOC. Stroma-rich tumors have a worse prognosis and, in the case of NACT, a higher likelihood of pleural metastasis. OTSR provides a cost and time-efficient way of determining TSR with high reproducibility and reduced inter-observer variability.
Management of Knee OsteoArthritis(KOA) is improving:A scoping review and quality appraisal of Clinical Practice Guidelines for KOA using the AGREE II and RIGHT
Authors: Liu Luping , Wang Xiyou , An Yi , Zhang Lingyun , Gao Yixuan , Yu Changhe
Published: November 2023

Background : Clinical practice guidelines (CPGs) are essential in healthcare, but their quality varies. This study aims to analyze 18 high-quality CPGs for knee osteoarthritis (KOA), identify areas for improvement, and establish common recommendations from contemporary CPGs for effective KOA management.Methods: We systematically searched guideline websites and databases until June 30, 2023, for KOA-related guidelines. Two independent reviewers assessed these using AGREE II and RIGHT checklists. The intra-class correlation coefficient (ICC) evaluated reviewer agreement, and recommendations and evidence levels were summarized.Results: We analyzed 18 Clinical Practice Guidelines (CPGs) from 1,411 records. Most were from China and the USA, published from 2016 to 2022, with 44.44% updates. Methodological quality was reliable, with 14 CPGs "recommended," but three had low "editorial independence" scores. Reporting quality ranged from 41.43–95.71%, with 66.66% scoring ≥ 80%. Recommendations included conservative measures, Tai Chi, Yoga, cane use, and various complementary and alternative medicines. Topical NSAIDs, oral NSAIDs, and intra-articular glucocorticoids were favored. Foreign guidelines stressed shared decision-making and patient preferences in KOA management.Conclusions: Over half of KOA CPGs are of good quality. However, there's substantial methodological variation and reporting quality gaps. Future efforts should enhance both. Our research supports a core set of interventions, including education, exercise, weight management, and personalized NSAID use, for evidence-based KOA practice and guideline development
Tumor necrosis factor- α Inhibition analysis by chemotherapy agent through QM/MM studies
Authors: S Mohammed zaidh , Navabshan IRFAN , M Salman
Published: November 2023

TNF (Tumor Necrosis Factor) is a multifunctional cytokine with a strong pro-inflammatory action and it is a proven therapeutic target receptor for a variety of autoimmune and inflammation-related illnesses. The current investigation is looking for a new chemotherapy small lead molecule that can directly bind to TNF receptors and modify the conformation. The TNF-α fold was docked with the 56 AI-designed molecules by a three-step algorithm in the Schrodinger Maestro interface. The interaction analysis results revealed that the best-hit molecule with a binding capacity score of -6.987 Kcal/mol and the MMGBSA value was found to be -52.42 Kcal/mol with the TNF receptor. Interaction map illustrates that 29 active amino acid of TNF receptor networked through 3 hydrogen bond, hydrophobic, 2 Salt bridges and negative charges type interactions with ring system such as piperazine and azetidine od the best hit molecule. Further, the environment solvent stability was confirmed using MD simulation in Desmund interface and analyzed the trajectory at 100 ns scale level, and it concludes that the formed bonds are 40–99% strong enough to modify the secondary structure of the TNF-α. Which leads target specific inhibition and safe chemotherapy agent for Tumor necrosis factor (TNF-α)
Caregivers’ Treatment-Seeking Time for Diarrhea in Under-Five Children in Uganda: A Multilevel Proportional Hazards Analysis
Authors: Tumusiime Sula , Asimwe John Bosco , Atuhaire Leonard , Wasswa Ronald , Nsimbe Dick , Brian Kayera
Published: November 2023

Background
Diarrhea is considered to be one of the major public health concern in developing countries. It is attributed to one of the highest mortality rates among children both globally and in Sub-Sahara Africa with 2 in 10 children in Uganda under the age of 5 dying. The objective of this study was to investigate the factors associated with time to seeking treatment among children under the age of five years suffering from diarrhea in Uganda.
Method
DOVE dataset of 746 caretakers in a prospective cohort study using multi stage sampling design was used in the assessment. The analysis was done using a time-to-event approach using life tables and multilevel proportional hazards model.
Results
The median time to seeking treatment by the time of the study (N = 746) was 2 days (range, 1–30 days) from the onset of diarrhea. The estimated frailty variance is 0.128, indicating heterogeneity across regions. Significant factors found to influence time to diarrhea treatment seeking include male children (HR = 0.821; 95% CI = 0.707–0.954, p = 0.010), those from richest wealth quintile (HR = 1.372; 95% CI = 1.051–1.791, p = 0.020), those living 5–10 KM from health facility (HR = 0.613; 95% CI = 0.411–0.912, p = 0.016), and those living more than 15 KM from health facility (HR = 0.695; 95% CI = 0.553–0.875, p = 0.002).
Conclusions
The findings are informative to policy on the behavior of seeking treatment. The results are also important in formulation of program strategies and interventions by different stakeholders that are geared towards reducing child morbidity and mortality due to diarrhea in relation to seeking treatment. The study also recommends other researchers to consider mixed methods analysis involving both qualitative and quantitative approach may provide a better understanding about the treatment seeking behaviors.
Inpatient outcome of upper cervical fractures in the elderly: a retrospective analysis of 268 cases.
Authors: Hoeh Nicolas Heinz von der , Keuchel Jonathan , Pieroh Phillip , Spiegl Ulrich Josef Albert , Osterhoff Georg , Heyde Christoph-Eckhard
Published: November 2023

Background
The incidence of upper cervical fractures in elderly individuals is increasing, necessitating enhanced treatment approaches.
Method
A retrospective study of 268 elderly patients with upper cervical fractures was conducted to assess inpatient outcomes aged 75 and older with atlas and/or axis fractures. Patient risk was evaluated using the ASA score and Charlson comorbidity index (CCI). In-hospital mortality and functional outcomes were assessed, with fracture treatment strategies following AO principles.
Results
Patients with C1, C2 or combined fractures did not differ in age, CCI, Barthel score or length of hospital stay (p > 0.05). C2 fractures were predominant, and the majority of patients suffered at least from a severe general disease (ASA ≥ 3). Comparing operatively and conservatively treated patients, regardless of fracture localization, revealed no significant differences in mortality, both overall and time-related. Surgical patients experienced a higher frequency of general complications, notably dyspnea. The overall mortality rate was 14.9%, with 15.7% in the nonoperative group and 14.4% in the surgical group (p = 0.8628). The overall rate of general complications was 51.4% (n = 51) in the nonoperative group and 71.9% (n = 110) in the operatively treated group.
Conclusion
The in-hospital mortality and morbidity of elderly patients with upper cervical fractures are high but do not significantly differ between operatively and nonoperatively treated patients. The complexity of the geriatric patient population highlights the need for peri- and postinpatient geriatric complex treatment, emphasizing the importance of establishing geriatric-specialized care structures.
Ontogenetic shifts in sex ratios support multiple adaptive explanations for temperature-dependent sex determination
Authors: Terebiznik Mariel , Farrell Maxwell , Rollinson Njal
Published: November 2023

Temperature-dependent sex determination (TSD) is found in all reptile groups, but its adaptive significance is a mystery. This is because most TSD reptiles feature extreme longevity, so assessing lifetime fitness is incredibly difficult. Here we combine classical sex ratio theory with a dataset of stage-specific sex ratios from a diversity of wild reptile populations to infer patterns of sex-specific mortality (fitness) across ontogeny. We disentangle whether there is a single or multiple adaptive explanations for TSD, provide insight into what those explanations are, and align the adaptive explanations with major reptile clades. We find that TSD evolved in turtles and crocodilians so that males develop in high-quality patches, supporting an extension of the Trivers-Willard hypothesis where the fitness of males under sexual selection is more sensitive to body condition than female fitness. We further find that stage-specific patterns of mortality are different in squamates, where TSD may have evolved to match females with high-quality patches that facilitate early maturation and high fecundity. We suggest if TSD evolved in long-lived reptiles because incubation temperature is a pervasive agent that influences stress, then it may be embryonic stress in general, not just thermal stress, that is the fundamental driver of TSD evolution.
Quality Improvement Project to Transition Psychosocial Oncology Clinical Care to a Telehealth Workflow during the COVID-19 Pandemic: a Quasi-Experimental Study
Authors: Sethi Rickinder , Lyver Brendan , Gorla Jaswanth , Forbes Robin , Sheehan Kathleen A , Schulz-Quach Christian
Published: November 2023

Introduction.
The COVID-19 pandemic created an urgent need for an innovative method of care delivery for psychosocial oncology. The psychosocial oncology services at the University Health Network in Toronto, Canada transitioned expeditiously to digital technologies that were readily available and accessible for patients and clinicians, facilitating care provision while reducing the transmission of COVID-19. This study aims to provide a validated framework for transitioning to digital delivery methods of care.
Methods.
A quality improvement team was established and tasked with successfully transitioning services from primarily in-person to digital delivery methods of care quickly and seamlessly. This included analyzing the psychosocial oncology workflow, planning and implementing a digital transition, and collecting data and feedback on the impact of this digital workflow through the use of surveys.
Results.
The average response rate of the surveys was 69.1%. Feedback and data collection demonstrated that more than 90% of psychosocial oncology processes were completed with digital tools following the transition with limited impact on clinical delivery. The clinicians reported feeling confident and satisfied providing care using digital workflow tools.
Conclusion.
The psychosocial oncology quality improvement team at the University Health Network provides a validated framework for transitioning to new methods of delivering care. As technology continues to develop, guidance on transitioning clinics and departments to new digital tools will be crucial for healthcare institutions. The framework provided in this study can be utilized to ensure the successful implementation of new technologies.
Do we over- or underestimate the overall cost burden of infectious diseases in ageing adults?
Authors: Standaert Baudouin , De Cock Anne-Marie
Published: November 2023

Background
arithmetic average values about disease burden across ageing adults are often used, which assumes homogeneity in group characteristics such as age, sex, disease frequency (incidence rates), and cost distributions. The question arises about how much outcome results such as overall cost obtained under this homogeneity assumption deviate from real-world population data that may manifest non-homogeneous distributions.
Methods
the method explores the amount of deviation measured between homogeneity versus non-homogeneity for overall infection costs in ageing adults as the outcome measure to assess. Population modelling is used with an extended sensitivity analysis plan (ESAP) that simulates non-homogeneous, age-specific distributional spread for demography, infectious disease, and its severity in people aged > 65 years old over a 1-year period in univariant and multivariant assessments. Costs are adjusted for 3 severity levels with increased difference between them using multiplication factors.
Results
the assumed full homogenous dataset systematically overestimates up to 10% the overall cost in ageing adults when compared with a group simulated with non-homogeneous distributions for age, infection, severity, and cost, mainly due to the demographic age-composition. Overall cost of a proposed homogeneous condition tends to underestimate the spending of non-homogeneous conditions when the reference case has a partial homogeneous set-up or when the demographic change in the non-homogeneous condition evolves towards age-demographic homogeneity (same number of people with increasing age), a likely evolution in the coming 10 to 20 years.
Conclusion
assessing the current cost burden of infectious diseases in ageing adults must consider exact age-composition of demography, infection spread with severity levels and their cost differences to avoid unrealistic cost estimates when assuming homogeneous group conditions.
Professional roles in transmission through sharing rituals: A critical ethnographic study of Norwegian recovery colleges
Authors: Sjursaether Therese Ersvaer , Øye Christine , Eriksen Kristin Ådnøy
Published: November 2023

Recovery colleges (RCs) represent innovation in mental health services. People with lived experience are brought together with professionals to design and deliver all aspects of the RC. This paper examines the transmission of roles when co-creating new mental health services. We conducted a critical ethnographic study and collected data from participatory observations in RCs at two locations and interviews with leaders with professional backgrounds and lived experiences. The analysis based on perspectives of communitas by Turner and social ties drawing on Barnes shows that co-creation practices imply the interplay between structure and anti-structure. In RCs, traditional service roles and normative structures in existing mental health services are dissolved or redefined. Some elements in this interplay are initiating sharing rituals, leaders' continuous assessments of what they share, and inviting participants to take on new roles and positions. Course leaders facilitate the co-creation of knowledge sharing and course content by initiating sharing rituals that promote equality and communitas. We can understand this dissolution of the normative social structure as a liminal state in which leaders gradually transmit into a new position with a less prominent professional façade. However, significant differences in social status and the daily lives of leaders and participants challenge communitas, indicating that the dissolution of roles can be temporary. We need more in-depth studies to discover the sustainability of roles in transmission in mental health services.