bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of (Pro)Renin Receptor in the Metabolic Syndrome
Authors: Yiannikouris Frederique , Nichols Kellea
Published: February 2022

The prorenin receptor (PRR) is a complex multi-functional single transmembrane protein re-ceptor that is ubiquitously expressed in organs and tissues throughout the body. PRR is involved in dif-ferent cellular mechanisms that comprise the generation of Angiotensin II, the activation of Wnt/β-catenin signaling, the stimulation of ERK 1/2 pathway, and the proper functioning of the vacuolar H+-ATPase. Evidence supports the role of PRR and its soluble form, sPRR, in the classical features of the metabolic syndrome, including obesity, hypertension, diabetes, and disruption of lipid homeostasis. This review summarizes our current knowledge and highlights new advances in the pathophysiological function of PRR and sPRR in adipogenesis, adipocyte differentiation, lipolysis, glucose and insulin resistance, lipid homeostasis, energy metabolism, and blood pressure regulation.
Hormone-Dependent Regulation of Renin and Effects on Prorenin
Receptor Signaling in the Collecting Duct
Authors: Prieto Minolfa C. , Lara Lucienne S. , Gonzalez Alexis A. , Hennrikus Matthew T.
Published: February 2022

The production of renin by the principal cells of the collecting duct has widened our understanding of the regulation of intrarenal angiotensin II (Ang II) generation and blood pressure. In the collecting duct, Ang II increases synthesis and secretion of renin by mechanisms involving the activation of Ang II type 1 receptors (AT1R) via stimulation of the PKCα, Ca2+ and cAMP/PKA/CREB pathways. Additionally, paracrine mediators, including vasopressin (AVP), prostaglandins, bradykinin (BK) and atrial natriuretic peptide (ANP) regulate renin in principal cells. During Ang II-dependent hypertension, despite plasma renin activity suppression, the renin and prorenin receptor (PRR) are upregulated in the collecting duct and promote de novo formation of intratubular Ang II. Furthermore, activation of PRR by its natural agonists, prorenin and renin, may contribute to the stimulation of profibrotic factors, independent of Ang II. Thus, the interactions of RAS components with paracrine hormones within the collecting duct enables tubular compartmentalization of the RAS to orchestrate complex mechanisms that increase intrarenal Ang II, Na+ reabsorption and blood pressure.
Recent Update on the Development of Leucine-Rich Repeat Kinase 2
(LRRK2) Inhibitors: A Promising Target for the Treatment of Parkinson’s
Disease
Authors: Patel Ashish , Patel Stuti , Mehta Meshwa , Patel Yug , Langaliya Dhruv , Bhalodiya Shyam , Bambharoliya Tushar
Published: February 2022

Parkinson’s disease is a relatively common neurological disorder with incidence increasing
with age. Since current medications only relieve the symptoms and do not change the course of
the disease, therefore, finding disease-modifying therapies is a critical unmet medical need. However,
significant progress in understanding how genetics underpins Parkinson's disease (PD) has opened
up new opportunities for understanding disease pathogenesis and identifying possible therapeutic
targets. One such target is leucine-rich repeat kinase 2 (LRRK2), an elusive enzyme implicated in
both familial and idiopathic PD risk. As a result, both academia and industry have promoted the development
of potent and selective inhibitors of LRRK2. In this review, we have summarized recent
progress in the discovery and development of LRKK2 inhibitors as well as the bioactivity of several
small-molecule LRRK2 inhibitors that have been used to inhibit LRRK2 kinase activity in vitro or in
vivo.
Dihydroartemisinin Induces ER Stress-Mediated Apoptosis in Human Tongue
Squamous Carcinoma by Regulating ROS Production
Authors: Zhou Qun , Ye Fangfei , Qiu Jiaxuan , Zhang Siying , Jiang Qingkun , Xue Danfeng , Li Jialun
Published: February 2022

Background:

Tongue squamous cell carcinoma is a fatal disease characterized by high invasion and early
metastasis. Dihydroartemisinin, an antimalarial drug with multiple biological activities, is reported to be a potential
anti-cancer agent.

Objective:

This study aimed to evaluate the antitumor effect of Dihydroartemisinin on tongue squamous cell carcinoma
cells, and to identify the underlying mechanisms of Dihydroartemisinin-induced cell apoptosis.

Methods:

Here, Cell Counting Kit 8 assay and colony formation assay were conducted to study cell proliferation. Annexin
V-FITC/propidium iodide staining and western blot analysis were performed to analyze cell apoptosis. DCFHDA
probe was used to measure the generation of cellular reactive oxygen species. Endoplasmic reticulum stress activation
was also determined via western blot analysis.

Results:

The results showed that Dihydroartemisinin substantially inhibited cell proliferation and induced cell apoptosis
in vivo. Moreover, reactive oxygen species production and endoplasmic reticulum stress activation were both observed
after stimulation with Dihydroartemisinin. However, the reactive oxygen species inhibitor N-acetylcysteine
significantly alleviated Dihydroartemisinin-induced endoplasmic reticulum stress and apoptosis.

Conclusion:

These results imply that Dihydroartemisinin induced cell apoptosis by triggering reactive oxygen speciesmediated
endoplasmic reticulum stress in CAL27 cells. In addition, Dihydroartemisinin might be an effective drug for
tongue squamous cell carcinoma therapy.
Phytochemical-rich Fractions from Foxtail Millet (Setaria italica (L.) P. Beauv) Seeds Exhibited Antioxidant Activity and Reduced the Viability of Breast Cancer Cells In Vitro by Inducing DNA Fragmentation and Promoting Cell Cycle Arrest
Authors: Kuruburu Mahadevaswamy G. , Bovilla Venugopal R. , Leihang Zonunsiami , Madhunapantula SubbaRao V.
Published: February 2022

Background:

The demand for millet-based diets has increased significantly in recent years due to their
beneficial effects on human health. Foxtail Millet (Setaria italica (L.) P.Beauv, previously known as Panicum italicum
L., referred as FTM in this manuscript) seeds have been not only used as astringent and diuretic agents, but they are
also used to treat dyspepsia and rheumatism. Recent studies have shown that solvent extracts from FTM seeds exhibited
antioxidant and antiinflammatory activities. However, the nature and antiproliferative potential of phytochemical
constituents of solvent extracts are not much explored.

Objectives:

Major objectives of this study are to generate and characterize the phytochemical-rich fractions from Foxtail
millet seeds, test the antioxidant activity, and antiproliferative potential against cell lines representing carcinomas
of the breast, and determine the mechanisms of cell growth inhibition.

Methods:

Phytochemical-rich fractions were generated by extracting the seeds using 70% ethanol (FTM-FP) and 10%
alkali (FTM-BP). Antioxidant potential was determined by ferric reducing antioxidant power (FRAP) assay and DPPH
radical scavenging activity assays. The antiproliferative potential was determined using sulforhodamine-B assay. The
impact on cell cycle and DNA fragmentation was analyzed by staining the cells with DAPI followed by analyzing the
stained cells using NC-3000.

Results:

Analysis of the results showed the presence of phenolics and flavonoids in the FTM-FP and FTM-BP fractions.
Both fractions exhibited antiproliferative potential against breast cancer cell lines. Mechanistically, both fractions
induced G2/M cell cycle arrest and increased the fragmentation of DNA, which lead to the accumulation of cells in the
Sub-G1 phase.

Conclusion:

In summary, results of this study demonstrated the potential of foxtail millet phytochemical fractions for
retarding the proliferative potential of breast cancer cells.
Monensin Inhibits Anaplastic Thyroid Cancer via Disrupting Mitochondrial Respiration
and AMPK/mTOR Signaling
Authors: Li Yanli , Sun Qianshu , Chen Sisi , Yu Xiongjie , Jing Hongxia
Published: February 2022

Objective:

The clinical management of anaplastic thyroid cancer (ATC) remains challenging, and novel
treatment methods are needed. Monensin is a carboxyl polyether ionophore that potently inhibits the growth of various
cancer types. Our current work investigates whether monensin has selective anti-ATC activity and systematically explores
its underlying mechanisms.

Methods:

Proliferation and apoptosis assays were performed using a panel of thyroid cancer cell lines. Mitochondrial
biogenesis profiles, ATP levels, oxidative stress, AMPK, and mTOR were examined in these cells after monensin
treatment.

Results:

Monensin is effective in inhibiting proliferation and inducing apoptosis in a number of thyroid cancer cell
lines. The results are consistent across cell lines of varying cellular origins and genetic mutations. Compared to other
thyroid cancer cell types, ATC cell lines are the most sensitive to monensin. Of note, monensin used at our experimental
concentration affects less of normal cells. Mechanistic studies reveal that monensin acts on ATC cells by disrupting
mitochondrial function, inducing oxidative stress and damage, and AMPK activation-induced mTOR inhibition.
We further show that mitochondrial respiration is a critical target for monensin in ATC cells.

Conclusions:

Our pre-clinical findings demonstrate the selective anti-ATC activities of monensin. This is supported by
increasing evidence that monensin can be repurposed as a potential anti-cancer drug.
Bismuth Lipophilic Nanoparticles (BisBAL NP) Inhibit the Growth of Tumor Cells in
a Mouse Melanoma Model
Authors: García-Cuellar Claudia María , Cabral-Romero Claudio , Hernández-Delgadillo Rene , Solis-Soto Juan Manuel , Meester Irene , Sánchez-Pérez Yesennia , Nakagoshi-Cepeda Sergio Eduardo , Pineda-Aguilar Nayely , Sánchez-Nájera Rosa Isela , Nakagoshi-Cepeda María Argelia Akemi , Chellam Shankararaman
Published: February 2022

Aim:

The objective of this study was to analyze the antitumor effect of BisBAL NP in a mouse melanoma
model.

Material and Methods:

The antitumor activity of BisBAL NP on murine B16-F10 melanoma cells was determined
both in vitro (PrestoBlue cell viability assay and Live/Dead fluorescence) and in vivo, in a mouse model, with the following
15-day treatments: BisBAL NP, negative control (PBS), and cell-death control (docetaxel; DTX). Mouse survival
and weight, as well as the tumor volume, were recorded daily during the in vivo study.

Results:

BisBAL NP were homogeneous in size (mean diameter, 14.7 nm) and bismuth content. In vitro, 0.1 mg/mL
BisBAL NP inhibited B16-F10 cell growth stronger (88%) than 0.1 mg/mL DTX (82%) (*p<0.0001). In vivo, tumors
in mice treated with BisBAL NP (50 mg/kg/day) or DTX (10 mg/kg/day) were 76% and 85% smaller than the tumors
of negative control mice (*p<0.0001). The average weight of mice was 18.1 g and no statistically significant difference
was detected among groups during the study. Alopecia was only observed in all DTX-treated mice. The survival
rate was 100% for the control and BisBAL NP groups, but one DTX- treated mouse died at the end of the treatment
period. The histopathological analysis revealed that exposure to BisBAL NP was cytotoxic for tumor tissue only, without
affecting the liver or kidney.

Conclusion:

BisBAL NP decreased the tumor growing in a mouse melanoma model without secondary effects, constituting
an innovative low-cost alternative to treat melanoma.
Effect of Pelargonium graveolens on Glucose Metabolism in Streptozotocin- Induced Diabetic Rats
Authors: Eddouks Mohamed , Fadwa El-Ouady , Amtaghri Smail , Akdad Mourad , EL-Haidani Ahmed
Published: February 2022

Aims:

The study aimed to assess the antihyperglycemic activity of Pelargonium graveolens.

Background:

Pelargonium graveolens (P. graveolens) (Geraniaceae) is a medicinal plant frequently used in traditional medicine in Morocco and Algeria as a remedy against a multitude of illnesses. Interestingly, it is also used in the Moroccan pharmacopeia for managing diabetes.

Objective:

The current study was carried out in order to assess the antihyperglycemic activity of P. graveolens in normal and streptozotocin(STZ)-induced diabetic rats, as well as to evaluate the acute toxicity of the aqueous extract of leaves of Pelargonium graveolens (PGLAE).

Methods:

The therapeutic effect of PGLAE at a dose of 40 mg/kg on blood glucose levels was investigated in normal and STZ-induced diabetic rats after a single oral (6h) and a repeated (15 days) oral administration. The acute toxicity of the PGLAE was examined in accordance with the OECD test guideline. Post-treatment, body weight, signs of toxicity, and/or mortality were observed for 14 days. Further assays, such as the oral glucose tolerance test, histopathological examination, and antioxidant activity, were also performed according to standard protocols.

Results:

Findings exhibited that both single and repeated oral doses of PGLAE (40 mg/kg) caused a significant reduction in blood glucose levels of normal and diabetic rats. All treated animals survived and no apparent adverse effects were observed during the duration of the acute toxicity study. Importantly, oral LD50 of PGLAE was greater than 2000 mg/kg BW. Furthermore, a remarkable influence on glucose tolerance was also noticed after PGLAE treatment. Moreover, PGLAE was able to improve the histopathological structure of the liver and possesses a potential antioxidant effect in vitro.

Conclusion:

In conclusion, this study reported the antidiabetic effects of PGLAE in rats, supporting its traditional use for the management of diabetes.
Intercultural learning in pandemic era
Authors: Eripuddin Eripuddin , Jufrizal Jufrizal , Agustina Agustina
Published: February 2022

This study investigated the students' intercultural learning in online classes during the pandemic era. The purpose of this study was to find out the reflection of intercultural learning in the EFL language of sixth-semester students of the English Study Program at Pasir Pengaraian University. This research was descriptive qualitative. The sample of this study was 30 students. The instruments of collecting data were questionnaires and interviews. This study shows that the students' intercultural learning was reasonable. In the teaching and learning process, there was no misunderstanding about the nature or actions of students from different cultural and language backgrounds in teaching and learning activities. Indeed, the process of teaching and teaching runs well. Each student could communicate well and make a good relationship with other people from different cultures. In short, students could develop a broader understanding of their language and cultural differences in the teaching and learning process during the pandemic era.
Germinación, crecimiento inicial y morfología de Castilla elastica (Moraceae) en Tabasco, México
Authors: Custodio-Rodríguez José P. , Vargas-Simón Georgina , Contreras-Sánchez Wilfrido M.
Published: February 2022

Antecedentes y Objetivos: Castilla elastica es una especie nativa de Mesoamérica asociada a diferentes culturas prehispánicas que utilizaban su látex para fines ceremoniales. Es un árbol emblemático, útil en sistemas agroforestales. Este trabajo tuvo por objetivo evaluar la germinación, crecimiento inicial y morfología de C. elastica.
Métodos: Se colectaron semillas de 30 árboles y se sembraron en bandejas de polietileno. El inicio de la germinación se determinó por la emergencia de los epicótilos. Se cuantificó el porcentaje de germinación y se establecieron tres periodos de evaluación del crecimiento cada 45 días. Se evaluaron la longitud de tallo (Lt) y el diámetro de tallo (Db). Se obtuvo la tasa absoluta de crecimiento (TAC) y la tasa relativa de crecimiento (TRC). Adicionalmente, se realizaron pruebas de regresión simple entre Lt y Db y se calculó una regresión asociando la TAC de la Lt con algunas variables climáticas. La evaluación del crecimiento tuvo una duración de 205 días.
Resultados clave: Se obtuvo 100% de germinación, el proceso inició a los 12 días. A los 205 días, las plantas alcanzaron una Lt y un Db promedio (±1 DE) de 36.5 cm (±5.27) y 8.2 mm (±0.55), respectivamente. Los tres períodos de evaluación mostraron diferencias estadísticas significativas. De acuerdo con los modelos de regresión, C. elastica crece 0.188 cm día-1 por cada milímetro de incremento en Db.
Conclusiones: La utilización de semillas recién cosechadas asegura 100% de la germinación. Se obtuvieron diferentes etapas de desarrollo de la plántula en función del tiempo (205 días). La TRC disminuyó después de la primera evaluación atribuible a la radiación solar. Este trabajo demostró la factibilidad de producir plantas de C. elastica y contar con el requisito mínimo como planta de calidad en cuanto a la Lt y Db promedio.
Teaching Students About Plagiarism Using a Serious Game (Plagi-Warfare): Design and Evaluation Study (Preprint)
Authors: Ade-Ibijola Abejide , Young Keagan , Sivparsad Nashik , Seforo Mpho , Ally Suhail , Olowolafe Adebola , Frahm-Arp Maria
Published: February 2022

BACKGROUND

Educational games have been proven to support the teaching of various concepts across disciplines. Plagiarism is a major problem among undergraduate and postgraduate students at universities.

OBJECTIVE

In this paper, we propose a game called Plagi-Warfare that attempts to teach students about plagiarism.

METHODS

To do this at a level that is beyond quizzes, we proposed a game storyline and mechanics that allow the player (or student) to play as a mafia member or a detective. This either demonstrated their knowledge by plagiarizing within the game as a mafia member or catching plagiarists within the game as a detective. The game plays out in a 3D environment representing the major libraries of the University of Johannesburg, South Africa. In total, 30 students were selected to evaluate the game.

RESULTS

Evaluation of the game mechanics and storyline showed that the student gamers enjoyed the game and learned about plagiarism.

CONCLUSIONS

In this paper, we presented a new educational game that teaches students about plagiarism by using a new crime story and an immersive 3D gaming environment representing the libraries of the University of Johannesburg.
eHealth in Norway Before and After the COVID-19 Pandemic (Preprint)
Authors: Schopf Thomas
Published: February 2022

BACKGROUND

Regular teledermatology services were implemented in Norway in the early 1990s. Based on the available technology at the time, live interactive video consultation systems were implemented to facilitate remote consultations between dermatologists and general practitioners. With the introduction of digital cameras some years later, store-and-forward systems were introduced, but the live video systems remained popular. In the 2000s and early 2010s, there were few changes in the volume of Norwegian teledermatology services. During the 2010s, private teledermatology companies emerged, which provided both store-and-forward and live interactive video consultations. While previous services involved specialists and general practitioners, the new services now offered to patients enable them to interact with dermatologists directly.

OBJECTIVE

This lecture aimed to provide a brief overview of the development of telemedicine in Norway before and during the COVID-19 pandemic with special focus on teledermatology.

METHODS

This lecture provides a brief history of telemedicine in Norway with special attention to the impact of the ongoing COVID-19 pandemic. The content is based on personal experiences and literature references.

RESULTS

The COVID-19 pandemic has had a profound impact on all parts of society. In Norway, it has also affected the way telemedicine is practiced. When the number of new infections increased substantially in early 2020, Norway was under lockdown. This had major consequences on the health care system. In response, the Norwegian government and health authorities strongly encouraged the use of telemedicine and implemented measures to support its use. Since then, there has been a large increase in the number of live video consultations both in specialist and community health care.

CONCLUSIONS

When the necessary technical infrastructure is in place, the remaining barriers to telemedicine use, such as reimbursement and integration of health care systems, can easily be overcome, which would result in high adoption rates of telemedicine.
Racial disparities in patient provider communication in telehealth versus face-to-face visits: a focus on Asian and Native Hawaiian and Other Pacific Islander cancer patients (Preprint)
Authors: Acoba Jared David , Yin Chelsea , Meno Michael , Abe Justin , Pagano Ian , Tamashiro Sharon , Fujinaga Kristy , Braun-Inglis Christa , Fukui Jami
Published: February 2022

BACKGROUND

Telehealth services are becoming increasingly more common in the care of oncology patients since the advent of the COVID-19 pandemic. However, it is not known if patient-physician communication via telehealth is equally effective among all racial groups.

OBJECTIVE

The objective of this study was to compare patient satisfaction with communication during telehealth versus face-to-face visits among oncology patients with a specific focus on Asian and Native Hawaiian and Other Pacific Islander (NHOPI) patients.

METHODS

We performed a cross-sectional study of a racially diverse group of cancer patients who had experienced a face-to-face or telehealth visit. Questions assessing satisfaction with patient-physician communication were adapted from a previously published study of a racially diverse population of cancer patients. Variables impacting communication included age, sex, household income, education level, and cancer type and stage were captured. Multivariable logistic models for patient satisfaction were created with adjustments for sociodemographic factors.

RESULTS

There were a total of 593 participants, 362 in the face-to-face group and 231 in the telehealth group. Racial distribution of the population was 24% White, 58% Asian, 13% NHOPI, and 5% other. Participants who attended a face-to-face visit reported higher levels of satisfaction in all communication measures than those who underwent a telehealth encounter. Lower levels of satisfaction during telehealth visits were demonstrated among Asian and NHOPI participants compared to Whites even after adjusting for sociodemographic factors. For example, degree of agreement with the statement, “Your physician listened carefully to you” was significantly lower among both Asians (OR 0.27, 95% CI 0.12 to 0.62) and NHOPI (OR 0.20, 95% CI 0.08 to 0.57) patients. Importantly, there were no significant racial differences in communication during face-to-face visits.

CONCLUSIONS

Asian and NHOPI patients were significantly less content with patient-physician communication during telehealth visits than White patients. This difference between racial groups was not seen in face-to-face visits. The observation that telehealth increases racial disparity in healthcare satisfaction should prompt further exploration.
La plateforme et le patrimoine : une enquête sur les valeurs des vidéos de concerts sur YouTube
Authors: Spanu Michaël
Published: February 2022

Background: With the evolution of digital technologies, concerts have become a form of mediated content whose value is still poorly understood. This article proposes to consider the case of concert videos on YouTube featuring popular music.

Analysis: For this purpose, we analyze a sample of concert videos filmed in Montreal, given the strong interconnection in this city between local musical scenes and the live performance industry alongside the image of creativity conveyed by large metropolitan centres.

Conclusion and implications: The results reveal a great diversity of participants, types of content and modes of reception that together allude to an ambivalent system of values, at the intersection on the one hand of a logic of flux, promotion and performance typical of the new platform economy and on the other of a documentary and archivistic logic, not to say a heritage-based one. These results are discussed in reference to that area of study that focuses on the legacy of different types of popular music.
Apoyo social y carga del cuidador del paciente con cáncer: revisión sistemática
Authors: Montalvo-Prieto Amparo Astrid , Sierra-Leguía Luis , Carmona-González Yolima
Published: February 2022

La presencia de una enfermedad crónica se constituye en una vulnerabilidad para la persona enferma, y para su cuidador sensación de descontrol e impacto emocional y físico, resultando en sobrecarga. Objetivo: Identificar los hallazgos relacionados con el apoyo social percibido y la carga de cuidado del cuidador familiar del paciente con cáncer en estudios publicados durante el período 2015 a 2021. Métodos: revisión sistemática de literatura, a través de la ecuación: (Social Support) AND (family caregivers) AND (burden of disease) OR (Caregiver Burden) AND (neoplasm), en español, inglés y portugués, en las bases de datos MedLine, Sciencedirect, Sage Journal y Academic Search Complete. Resultados: Se obtuvo un total de 29396 artículos, de los cuales se seleccionaron 23 artículos luego de aplicar los filtros y los criterios de elegibilidad establecidos por los investigadores. Conclusiones:  La angustia que percibe el cuidador refleja un moderado apoyo social y una mayor carga. El acompañamiento de los grupos de apoyo para el cuidador y sujeto de cuidado, les permiten compartir, sentirse aceptado, fortalecer la salud física, mental y disminuir la angustia y el desgaste emocional.
Subjetividade e enunciação em Benveniste: fundamentos de uma Semântica linguística (Subjectivity and enunciation in Benveniste: oundations of a linguistic Semantics)
Authors: Santos Jorge Viana
Published: February 2022

Neste artigo, a partir da releitura de textos fundamentais de Benveniste (1956/1966; 1958/1966; 1959/1966; 1965/1974; 1967/1974; 1969), buscamos detectar de que forma o autor, por formação um linguista histórico, e depois um expoente entre os estruturalistas, consegue, mesmo admitindo a noção de língua como sistema, trazer para a Linguística em meados do século XX a necessidade de se estudar um campo então novo e praticamente inexplorado, em vista do corte metodológico de Saussure (1916): a enunciação, e suas implicações. Postulamos que o pensamento benvenistiano articula, reinterpreta e por vezes desloca noções fundamentais de Breál (1897) e de Saussure (1916), no sentido de, com originalidade, conseguir abordar o sujeito na/da linguagem, no âmbito de uma Semântica linguística.
O papel do entrevistador na avaliação dos usuários de uma rede social (The role of the interviewer in evaluating users of a social network)
Authors: Pacheco Roberta Fernandes
Published: February 2022

Este artigo busca analisar a percepção do usuário do Facebook, demonstrada através de seus comentários em rede, sobre as atribuições discursivas do papel de atividade do entrevistador de um programa de entrevistas – Roda Viva –, transmitido ao vivo na página do Facebook do programa. A partir de uma abordagem qualitativa de análise, esse trabalho se baseia em: (a) Sarangi (2010) e Pacheco (2018, 2019) na discussão sobre o papel de atividade do entrevistador; (b) Ekström e Lundell (2009) e Lauerbach (2004) na abordagem das entrevistas de notícias e (c) Brandão (2017) e Fenelon et al. (2014) na discussão sobre o alcance das redes sociais. A análise permitiu observar que o internauta avalia negativamente a realização das atribuições discursivas do papel de atividade do entrevistador, evidenciando que a expectativa interacional do encontro não foi atendida, na avaliação da audiência.
CARVALHO, R. Ensinar a ler, aprender a avaliar: avaliação diagnóstica das habilidades de leitura. São Paulo: Parábola Editorial, 2018.
Authors: Figueiredo Camila Pilotto
Published: February 2022

O presente escrito visa fornecer um panorama da obra Ensinar a ler, aprender a avaliar: avaliação diagnóstica das habilidades de leitura, de Robson Carvalho, além de tecer comentários críticos acerca da mesma, como é esperado de uma resenha crítica.
Para começo de conversa: a variável linguística na interface sociofuncionalista (Starting the conversation: the linguistic variable in the sociofunctionalism interface)
Authors: Tavares Maria Alice , Pedro Fernando Laerty Ferreira da Silva , Albano Gabriela Fernandes
Published: February 2022

O primeiro passo de uma pesquisa variacionista é a circunscrição da variável linguística que será o objeto de estudo. Em uma perspectiva sociofuncionalista, nossos objetivos são: (i) mostrar como a convergência do conceito de variável linguística com o de macrodomínio funcional pode ser empregada como estratégia para a circunscrição da variável; (ii) aplicar essa estratégia a dois domínios funcionais, adversidade e a concessividade. As variantes de codificação desses domínios são multifuncionais: mas e só que, no caso da adversidade, e mesmo (que), apesar (de) que e nem que, no caso da concessividade. Concluímos o texto apontando vantagens da adoção da estratégia de delimitação de um macrodomínio como variável linguística.
A multifuncionalidade do verbo poner em língua espanhola: descrição e usos (The multifunctionality of the verb poner in Spanish: description and usage)
Authors: Rodrigues Roana
Published: February 2022

O comportamento sintático-semântico do verbo poner em língua espanhola é multifuncional, com padrões de uso diferenciado em construções locativas e de mudança de estado. Neste estudo, apresentamos a abordagem dada a este verbo em descrições sob diferentes perspectivas teórico-metodológicas e aplicamos os parâmetros de análise a um conjunto de dados em 150 frases construídas com poner retiradas do CORPES (Corpus del Español del Siglo XXI), a fim de observar a produtividade do uso. A classificação permitiu identificar os seguintes padrões de uso de poner como: (i) verbo-suporte (El señor nos pone a prueba); (ii) verbo pleno (Puso la botella en el suelo); (iii) construção gramatical (Se pusieron a cantar); (iv) verbo operador causativo (Aquel asunto la ponía nerviosa); e (v) constituinte de expressão cristalizada (Puso el grito en el cielo). Estes resultados permitem reflexões sobre a complexidade sintático-semântica de poner e evidenciam aspectos a serem considerados em programas de ensino de línguas para falantes de espanhol como língua estrangeira.
Multiscale analysis of monoglyceride oleogels during storage
Authors: Rondou Kato , Witte Fien De , Rimaux Tom , Dewinter Wim , Dewettinck Koen , Verwaeren Jan , Bockstaele Filip Van
Published: February 2022

Oleogelation offers the possibility to reduce the saturated fatty acid
(SAFA) content while maintaining the desired organoleptic properties.
Hereby, SAFA are replaced by other structurants which can create a
three-dimensional network that immobilizes the liquid oil. Depending on
the type of structurants, different structuring routes are identified.
The use of monoglycerides (MAGs) as structurants is a promising approach
thanks to their great self-assembling properties. However,
implementation into the food industry is still hampered due to
insufficient characterization. This research includes a multiscale
analysis of two dynamically produced MAG-based oleogels as a function of
the storage time (up to 8 weeks). Slight differences in the production
process resulted in differences in techno-functional properties between
the MAG-based oleogels MO1 and MO2. MO1 consisted of larger crystals,
which resulted in a lower rigidity, lower stability and lower oil
binding capacity compared to the other oleogel (MO2). On the nanoscale,
it was found that the crystal nanoplatelets (CNPs) of MO1 contained a
higher number of lamellae compared to the MO2. Additionally, the results
obtained with ultra-small angle X-ray scattering indicated a larger
equivalent diameter for the CNPs of MO1. As a function of the storage
time, both oleogels did not show major structural changes up to 8 weeks
of storage.
Implementation of the compliance system in the activities of agricultural enterprises in Ukraine: prerequisites and main aspects
Authors:   Mykolaiyv National Agrarian University, Dubinina Maryna , Ksonzhyk Iryna ,   Mykolaiyv National Agrarian University, Syrtseva Svitlana ,   Mykolaiyv National Agrarian University, Cheban Yuliia , Luhova Olha , Pisоchenkо Tetiana
Published: February 2022

The article defines the prerequisites and main aspects of implementation of the compliance system in activities of agricultural enterprises in Ukraine. It has been established that the compliance system for Ukrainian agricultural enterprises is completely new, and there are practically no procedures for its formation and functioning. Using SWOT analysis matrix, strengths and weaknesses, opportunities and threats of the compliance system for Ukrainian agricultural enterprises have been identified. It has been established that the agricultural business is able to ensure the implementation and operation of the compliance system, which is focused on international compliance values. An algorithm for introducing a compliance system into the activities of agricultural enterprises has been proposed. Its implementation and observance will allow agricultural enterprises to minimize compliance risks, ensure their financial stability and innovative development, increase trust of customers, partners and investors to be competitive both in the domestic market and external one. It has been determined that compliance risk management is a cyclical process, whose main goal should be to minimize the identified risks using the development and implementation of appropriate control procedures and measures. In order to minimize compliance risks arising in the process of relations between agricultural enterprises and counterparties, an organizational model of their management has been proposed. The application of the methodological approaches presented in the model will allow agricultural enterprises to establish working relationships with counterparties, including foreign ones, and in the future to attract foreign capital and investment in their activities.
The Effects of Firm Guidance on Auditors' Evaluations of Fair Value Estimates
Authors: Cohen Jeffrey R. , Gaynor Lisa Milici , Montague Norma R. , de Lima Salge Carolina Alves , Wayne Julie H.
Published: February 2022

Regulators are concerned that auditors are insufficiently skeptical in evaluating fair value estimates (PCAOB 2020). We employ Nolder and Kadous's (2018) professional skepticism model to examine how firm guidance impacts auditors' skeptical judgments and actions in the fair value context through their cognitive processing of confirming and conflicting evidence. We find that rewording firm guidance to include either a directional goal instructing them to oppose management's assertions or a bi-directional goal instructing them to support and oppose management's assertions lead auditors to gather more conflicting evidence than a directional goal instructing them to support management's assertions. However, gathering more conflicting evidence does not yield more skeptical actions unless auditors are instructed to support and oppose management's assertions. This is supported by theory suggesting that attending to both confirming and conflicting information forces individuals to reconcile the inconsistent information, enhancing the likelihood that it will be incorporated in their judgments.

JEL Classifications: C91; G18; M42.
Subsidiary Governance and Corporate Tax Planning: The Effect of Parent-Subsidiary Common Directors and Officers
Authors: Wang Xin , Xu Yongxin , Zhang Liandong , Zheng Gaoping
Published: February 2022

Top executives of the parent company often take positions as the directors and officers (D&Os) of subsidiaries. These parent-subsidiary common D&Os have better access to subsidiary information and can exert more influence over subsidiary operations. Therefore they can better identify tax-planning opportunities and coordinate tax arrangements. Using the mandatory disclosure of top executives' subsidiary positions for Chinese listed firms, we find that effective income tax rate is lower for firms with common D&Os. The tax-saving effect is stronger for firms with more intangible assets and with related-party transactions involving subsidiaries. The effect is also stronger when common D&Os have positions in economically significant subsidiaries and the subsidiaries entitled to preferential tax treatment and when common D&Os are involved in daily subsidiary operations. To our knowledge, this paper is the first to study the role of subsidiary governance in general and common D&Os in particular in corporate tax-planning.
Variation in Patient-Described Barriers to and Facilitators of Diabetes Management by Individual-Level Characteristics: A Cross-Sectional, Open-Ended Survey
Authors: Campbell David J.T. , Ghuttora Harleen , Mladenovic Ana , Smith Jordan , Leigh Ryan , Desveaux Laura , Ivers Noah , Manns Braden , Tonelli Marcello , Naugler Christopher , Hemmelgarn Brenda , McBrien Kerry A.
Published: February 2022

This study analyzed patient-described barriers and facilitators related to diabetes management, focusing on how these differ by glycemia and across individual characteristics. A cross-sectional telephone survey was conducted with adult patients with diabetes in Alberta, Canada, asking two open-ended questions to describe the most helpful and difficult components of their diabetes management. Responses were analyzed using directed content analysis using the Theoretical Domains Framework as a template. The most frequently cited facilitator was care context and information, and the most frequently cited barriers were cognitive challenges and structural barriers, with patient-perceived barriers and facilitators varying by individual-level factors.
Nye typer mat på alles fat. NRKs rolle som megler av nye tanker om mat
Authors: Brinch Sara
Published: February 2022

When televised, food, recipes and dishes are put into larger, meaningful contexts, relative to the type and agenda of a given television program. Food can represent a culinary culture, an expression of cuisine, a source of a healthy lifestyle, or even a dual societal problem: overproduction of food and food waste. Based on analysis of a selection of shows produced by the Norwegian public service broadcaster NRK, this chapter addresses the communicative strategies of television advocating for a more conscious consumer of foods and edible goods. Drawing on examples of the programs’ strategies of communication, the article describes three ways of acting as mediator: operating in a dialogic, action-based or relational mode, respectively.
Assessment of Watershed Carrying Capacity and Land Use Change on Flood Vulnerability Areas in Semarang City
Authors: Setyowati Dewi Liesnoor
Published: February 2022

Human behavior can cause watershed problems, in which the use and carrying capacity of the watershed do not correspond. The objectives of this research are to determine the land use conditions and carrying capacity of the watersheds, and to analyze this capacity based on changes in land use and flood vulnerability areas. The research was conducted in five watersheds flowing are in flood-prone areas of Semarang City, namely Babon, Banjir Kanal Timur, Garang, Silandak, and Beringin, with a research area of 48,994.62 Ha. A quantitative analysis approach was used to calculate the land-use change and watershed carrying capacity; the capacity variables included land conditions, water quality, population, water building, and watershed space utilization. The results show that 1) an average of 12.27% of land in each watershed unit has been converted into settlements, with the most extensive conversion being in the Banjir Kanal Timur watershed; 2) the carrying capacity of this watershed got 113 scores, which fell into the poor category; and 3) at the watershed level, the surge in land conversion into settlements correlates with the carrying capacity of the watershed. Conversion of land into settlements is one of the determinants of the carrying capacity of the watershed. If the land use arrangement in the watershed is made with consideration of flood-vulnerability areas, this will be able to reduce watershed damage and reduce the frequency of floods.
HARMONI BUDAYA DALAM RITUAL METHIKAN DI MASYARAKAT DESA PANGKAH TEGAL
Authors: Munfarida Elya
Published: February 2022

Methikan Ceremony, also called siametan gilingan, is one of the ceremonies held by the community of Pangkah and Sugar Factory of Pangkah as the organizer. The ceremony was held to mark the harvest and the beginning of milling sugar canes at the same time. The ceremony was preceded by harvesting (Java: methik) sugar canes on sugar plantations owned by farmers and factories to be treated as a pair of bride and bridegroom. The implementation of methikan ceremony was based on the religious system that can not be separated from the view of life (weltanchaung) and the Javanese world view on the achievement of certain spiritual values such as calmness, serenity and inner balance through the appreciation of society, nature and supernatural as an inseparable unity that must be actualized in appropriate actions.
evolución de la crisis del COVID en las portadas de la prensa española de referencia
Authors: López del Castillo Wilderbeek Francisco Leslie
Published: February 2022

Esta investigación ha analizado el tratamiento de la crisis del Covid en los titulares de los temas principales de portada de los tres diarios con mayor público en España. Mediante análisis de contenido y visualización de datos se ha buscado la existencia de correlaciones entre cobertura informativa y número de contagios, y si se producen cambios de tendencias informativas entre la primera y la segunda ola de la pandemia. Las conclusiones finales señalan que los diarios analizados muestran un desgaste potencial en el tratamiento informativo de la pandemia además de poner el foco en las normas que condicionan el estilo de vida.
libro Collage infinito
Authors: Vestfrid Pamela
Published: February 2022

Resumen
Se presentan las características principales del libro Collage infinito, editado en 2021 por Ediciones Hespérides. En el artículo su autora describe las ideas que dieron origen a la obra digital en el contexto de pandemia por Covid-19 donde la soledad, el silencio y la quietud fueron moneda corriente.
El libro de descarga gratuita, puede consultarse ingresando en bit.ly/3q4jgAf. Su autora combina la escritura creativa, el collage y la fotografía, como lenguajes artísticos indispensables para la creación. El lector puede recorrer y disfrutar 24 textos breves, que se encuentran acompañados por diversas imágenes, que buscan inspirar en un contexto signado por la complejidad.
En la presente reseña, la autora visibiliza las ideas que tiene sobre la escritura creativa, el collage y el autorretrato. Finaliza la misma sosteniendo que la vida es un collage, porque el collage recuerda que se puede crear a partir de fragmentos de procedencia diversa, que lo diferente se puede unir, para amalgamar un nuevo discurso, una nueva narrativa, que se vale de las potencialidades de cada retazo. Animarse ha sido la consigna de este tiempo, porque a pesar del mutismo, la soledad y la quietud, siempre hay espacio para la expresividad.
Prácticas Mestizas
Authors: Porta Paula Inés , Ferrarelli Mariana
Published: February 2022

Las prácticas mestizas, se podrían pensar como un modo de hacer que se sostiene desde diversas miradas, voces o disciplinas que allí se mezclan. Pensar la propia práctica como una convergencia de diversidades. En lo aúlico uno puede mezclar disciplinas, maneras de hacer, formatos; incluye lo sincrónico y lo asincrónico, lo digital y lo analógico pero no exclusivamente. También apuesta por los diálogos, por la apertura hacia múltiples mediaciones: la tecnológica, culturales, económicas, ideológicas, políticas e incluso mediaciones éticas. Prácticas Mestizas: apertura hacia cruces varios, y esta idea de cruce nos permite pensar el aula como zona de frontera bilingüe.Es una idea de Baricco en “The Game” que se articula con Freire: el docente como cruzador de fronteras, Jesús Martín Barbero, la interacción de Bajtin, hay mucha cosa del sentido de lo poscolonial de los estudios culturales que nutren la comunicación que ahora se activaron. Pensar el aula como una zona de frontera donde estamos como en el medio en donde convergen diferentes tiempos/espacios sujetos, lenguas y formatos me parece la mejor definición para este momento.
giro mediatizado de los museos
Authors: Panozzo Zenere Alejandra
Published: February 2022

La pandemia que afecta al mundo, desde el 2020, aceleró la posibilidad de convertir al museo en un facilitador de interacciones con y desde los públicos/destinatarios. En este sentido, la comunicación mediatizada se convierte en una posibilidad viable para comprender este cambio de paradigma al que aspiran este tipo de institución cultural.

Se apela, de este modo, a un enfoque interdisciplinar que atiende a una articulación entre el estudio de los museos y del marketing digital, bajo la mirada general de la comunicación mediatizada. Puntualmente, aquí, no abocaremos a analizar cuatro tipos de contenidos digitales presentes en las plataformas de los museos, con el propósito de delimitar sus rasgos en el presente y el tipo de relación que establecen con los públicos/destinatarios al proyectarse desde las tecnologías digitales.
De la ciudad real a la estabilización de una imagen ideal
Authors: Rojas Chediac Juan Ignacio
Published: February 2022

En el presente artículo, se indaga en las transformaciones que se dieron a raíz de la conformación y el crecimiento urbano de la ciudad de La Plata. Al ser un caso atípico, por su proyección y planificación previa a la construcción, existe un supuesto sobre un pasaje de una ciudad ideal - el cuadrado fundacional - que, por diversas cuestiones, se fue modificando y desarticulando hasta concretarse una ciudad real.

La hipótesis en la que se basa este artículo es que no hay mayores indicios de haya existido una ciudad ideal, salvo en su proyección, y que la transformación que se dio fue desde una ciudad real, que siempre superó al cuadrado fundacional, a la normalización de la imagen de una ciudad utópica. Fundada en un territorio que hasta el momento no estaba poblado, insertándose en un sistema productivo, cultural, social y político determinado, en donde la planificación de la ciudad es sólo un aspecto de su composición.

Se hará un análisis de la conformación y crecimiento de la ciudad de La Plata, desde su fundación hasta la actualidad, para ver cómo ha ido mutando la ciudad a lo largo de su historia, buscando observar dos cuestiones. Por un lado, cómo fue la relación entre el casco fundacional y sus periferias y, por el otro, cómo se fueron construyendo símbolos en torno al espacio urbano desde diversas instituciones públicas.
Narrar ESI en pandemia
Authors: Felli María Susana
Published: February 2022

Resumen

El presente trabajo establece un aporte para la proyección de la Educación Sexual Integral en el sistema educativo. “Narrar la ESI en pandemia: cuando el relato se transforma en acción” tiene como objetivo, entre otros, la propuesta de reflexionar sobre las mujeres y las conquistas de derechos. La invitación es trabajar en la deconstrucción de las ideas hegemónicas.  En este sentido, toman importancia algunas experiencias vinculadas con las políticas públicas, las articulaciones con los espacios de práctica docente y los programas socioeducativos.

 Además, es fundamental hacer notar que el contexto en el que se sitúa el artículo, trabaja en particular con los protagonistas del sistema educativo formal que, a la luz del ASPO, se configuran en sujetos que actúan para moldear sus propias prácticas.

En primera instancia, el trabajo contiene las argumentaciones necesarias para dejar en claro cuáles son aquellas epistemologías feministas que nos fundamentan como mujeres de pensamiento, debate y construcción de sentido. 

En segunda instancia, se trabajará la perspectiva de investigación narrativa en relación con la experiencia. De este modo, se presentan relatos de experiencias que  dan lugar a saberes que de otro modo se encuentran invisibilizados en lo institucional y en el discurso hegemónico social.