bluuebunny/crossref_metadata_2025 huggingface dataset:
CURRENT ASPECTS OF ETIOTROPIC COVID-19 THERAPY
Authors: Zemskov D. N. , Balykova L. A. , Radaeva O. A. , Zaslavskaya K. Ya. , Bely P. A. , Semenova E. V. , Shirmankina M. V. , Koryanova K. N.
Published: December 2022

Since the beginning of the pandemic, repeated attempts have been made to develop etiotropic therapy for a novel coronavirus infection. Hydroxychloroquine, lopinavir/ritonavir, etc. derivatives were used as antiviral agents, however, they demonstrated a low efficiency and an insufficient safety. In this connection, other groups of drugs with a more effective and safe pharmacological profile are currently being actively used.

The aimof the study was to analyze the literature references on the efficacy and safety of antiviral drugs for the COVID-19 treatment.

Materials and methods.When searching for the materials for the review article writing, such abstract databases as PubMed, Google Scholar, e-Library were used. The search was carried out on publications for the period from January 2020 to september 2022. The key queries were: COVID-19, etiotropic therapy; immunological drugs; antiviral drugs; interferons.

Results.Currently, there are various degrees of effective etiotropic drugs for the treatment of COVID-19 patients. The review has considered a few groups of drugs that are of interest from the point of view of etiotropic therapy: immunological drugs (anticovid plasma, the drugs based on antiviral antibodies, the drugs of recombinant interferons-α2 and -β1, as well as interferon inducers, i.e., the drugs based on double-stranded RNA sodium salt, and others); drugs that block the penetration of the virus into the cell (umifenovir); the drugs that disrupt the process of the viral replication (favipiravir, remdesivir, molnupiravir, nirmatrelvir/ritonavir).

Conclusion.Synthetic antivirals, in particular favipiravir, molnupiravir, remdesivir, and nirmatrelvir/ritonavir, have the largest evidence base for their efficacy and safety. The search for new effective and safe etiotropic drugs for the treatment of COVID-19, as well as the collection and analysis of post-registration data on the drugs already used in clinical practice, continues.
CHARACTERISTICS OF OLOKIZUMAB PHARMACOKINETICS IN PATIENTS WITH NOVEL CORONAVIRUS INFECTION COVID-19
Authors: Tavlueva E. V. , Zernova E. V. , Kutepova M. P. , Kostina N. E. , Lesina V. S. , Mould D. R. , Ito K. , Zinchenko A. V. , Dolgorukova A. N. , Nikolskaya M. V. , Lemak M. S. , Filon O. V. , Samsonov M. Yu.
Published: December 2022

The aim of the article is to study pharmacokinetic characteristics of intravenous olokizumab in patients with moderate COVID-19 to relieve a hyperinflammation syndrome.

Materials and methods. The pharmacokinetic study was conducted as a part of a phase III clinical study (RESET, NCT05187793) on the efficacy and safety of a new olokizumab regimen (intravenous, at the doses of 128 mg or 256 mg) in COVID-19 patients. Plasma concentrations of olokizumab were determined by the enzyme immunoassay. The population analysis was performed using a previously developed pharmacokinetic model based on a linear two compartment.

Results. The pharmacokinetic analysis included the data from 8 moderate COVID-19 patients who had been administrated with olokizumab intravenously at the dose of 128 mg. According to the analysis results in this population, there was an increase in the drug clearance, compared with the data obtained in healthy volunteers and the patients with rheumatoid arthritis: 0.435, 0.178 and 0.147 l/day, respectively. The parameters analysis within the framework of a population pharmacokinetic model showed that the main factors for the increased olokizumab clearance are a high body mass index. In addition, the presence of COVID-19 itself is an independent factor in increasing the drug clearance.

Conclusion. After the intravenous olokizumab administration, an increase in the drug clearance is observed in moderate COVID-19 patients against the background of the disease course. The main contribution to the increased clearance is made by the characteristics of the population of COVID-19 patients associated with the risk of a severe disease and inflammation. When administered intravenously at the dose of 128 mg, a therapeutically significant olokizumab level was maintained throughout the acute disease phase for 28 days.
Una reconstrucción histórica de la implementación de un modelo bilingüe en las escuelas de sordos de venezuela entre 1985 y 1996
Authors: Oviedo Alejandro
Published: December 2022

En 1985 inició el Ministerio de Educación en Venezuela el Modelo de Atención Integral al Niño Sordo, un cambio de la práctica oralista a un modelo bilingüe en las escuelas de sordos. Eso implicaba eliminar la enseñanza del español hablado como objetivo principal e introducir la Lengua de Señas Venezolana (LSV) a las escuelas. Se desencadenó así un intenso período de cambios que marcó indeleblemente a la comunidad sorda. Aquí se aborda el Modelo desde la perspectiva de la planeación lingüística, describiendo sus objetivos y sus efectos sobre la adquisición, la estructura (el corpus) y el estatus de la LSV: La LSV y el español señado fueron reubicados en la diglosia existente hasta entonces; surgió una variante académica de la LSV y aumentó el número de usuarios de la LSV. El estudio se basó en el análisis cualitativo de entrevistas realizadas a cinco testigos de aquel proceso.
Homeschooling
Authors: Matos Sandro Conceição de
Published: December 2022

O debate sobre a implementação do homeschooling no Brasil emerge com bastante efervescência no atual cenário político do país, marcado predominantemente pela extrema direita. Este artigo tem como objetivo fulcral apresentar uma crítica contemporânea à educação domiciliar enquanto modalidade educativa formal e informal que se opõe à educação escolar, oposição essa que remete à metáfora lacaniana sobre muro de linguagem. A pesquisa realiza uma abordagem qualitativa do tipo bibliográfico privilegiando leituras e fichamentos do dossiê Homeschooling e o Direito à Educação da Revista Pro-Posições (2017) e, também, de autores que abordam a problemática em torno da metáfora do muro de linguagem, em especial Jacques Lacan (2011). Os resultados sugerem a forte influência da educação informal no homeschooling, cuja propulsão na contemporaneidade é viabilizada pela política neoliberal, a qual enquadra a educação domiciliar como um elemento de interposição que separa os sujeitos a partir da classe social. Nessa lógica, os mais privilegiados conseguem acessar a educação domiciliar tornando-se indiferentes aos demais que acessam a escola, revelando, portanto, um comportamento narcisista entre os adeptos da educação domiciliar.
FROM COVID-19 TO PATIENT SAFETY: PRACTICE IN INDONESIA
Authors: Idris Haerawati
Published: December 2022

The December 2022 edition of the Indonesian health administration journal has been published. This time raised several topics about health system. Generally, the manuscripts submitted raise topics related to the issue of Covid-19. Other topics include access to health services, management programs, health insurance, and patient safety. Another topic of this edition also raises the issue of access to health services. Ainy (2022) The issue of Covid-19 is still a concern for researchers at this time. Covid-19 inspection services are still a necessity at this time. However, not all districts can prepare for this need. Imaniar (2022) reports that the availability of RT-PCR in Covid-19 tests is still limited at the district level. Since Covid-19, the use of online-based systems has increased. Murima reported (2022) that the use of telemedicine in health facilities during a pandemic greatly helped health service providers, but there were obstacles such as not being multidisciplinary and lack of knowledge in using technology.
A LITERATURE REVIEW OF TELEMEDICINE IN INDONESIA: PAST, PRESENT, AND FUTURE PROSPECTIVE
Authors: Wijaya Jeremiah Hilkiah , Octavius Gilbert Sterling , Hwei Lie Rebecca Yen
Published: December 2022

Background: Indonesia has a great potential in the development of digital health technologies. However, several challenges might also arise in hand with the development of telemedicine.
Aims: We aimed to conduct a literature review of the use of telemedicine in Indonesia in order to know how the start is, the development, and future considerations of its usage.
Methods: From the digital databases of PubMed, Google Scholar, and Neliti (Indonesia's Research Repository), each author completed literature searches of telemedicine in Indonesia from 1985 to 2021.
Results: A total of 8 studies were included in current literature review. In 1985-1987, Indonesia undertook the first satellite-based telemedicine. During the early twenty-first century, rapid improvements in information technology have expanded to other industries, including health care through telemedicine. Covid-19 dilemma compels physicians to adopt. Through telemedicine, many is experienced the benefit during the pandemic. However, in developing telemedicine system for the future, the use of telemedicine has several challenges, namely related to human resources, infrastructure and ethical regulations.
Conclusion: When telehealth is successfully implemented in Indonesia, it will benefit both the developer and the consumer. Despite the benefits, the challenge of implementing and developing a comprehensive eHealth environment in Indonesia might be seen as tremendous, given that the country is currently developing its infrastructure.
FROM HOSPITAL READINESS TO PATIENT SAFETY: BUILDING LEADERSHIP CAPACITY FOR PATIENT SAFETY IN INDONESIA
Authors: Engineer Cyrus Y , Dhamanti Inge
Published: December 2022

The COVID-19 pandemic has had an influence on patient safety and quality of care. A research undertaken in numerous countries found a deterioration in the quality of care during the pandemic. Leaders can improve patient safety in any circumstances, pandemic or not, by building a safety culture, reacting to patient and staff concerns, supporting safety activities, and tracking progress. Good leadership is essential to the success of patient safety programs and improving patient safety. Leaders must first establish strategic priorities and plans for culture and infrastructure that will aid in increasing patient safety. They must also actively inquire about patient safety situations and regularly examine patient safety data. Leaders must also collect data in order to foster a culture of patient safety. It is also critical to ensure that adequate infrastructure is available to support safety activities. Leaders have an important role in establishing the optimal methods for enhancing patient safety. Measures and improvement actions are rarely carried out in many nations; thus, leaders must ensure and encourage quality and safety development. Leadership commitment is the foundation for both pandemic and non-pandemic safety and quality improvement. Patient safety recommendations frameworks can help leaders improve patient safety in their organizations.
Terrorism and Weapons of Mass Destruction – A Dangerous Symbiosis
Authors: Oznobishchev S.
Published: December 2022

Against the backdrop of a sharp aggravation of the international situation, the growth of fundamental contradictions between Russia and Western countries, and the growing disunity of the international community, the terrorist threat is increasing. Its most dangerous manifestations are the attempts already made by terrorists to use elements of weapons of mass destruction (WMD), as well as to seize dangerous infrastructure facilities, including nuclear cycle facilities, the damage or destruction of which could lead to mass casualties. Recently, the threat of terrorist acts against high-risk civilian infrastructure has increased dramatically. Military operations in Ukraine and the concomitant violation of the working rhythm of the nuclear power plant, the weakening of the security system actually open the “gates” to both provocative forceful actions and the intrigues of terrorists or groups interested in escalating the armed conflict. Computer technology and Internet resources provide new opportunities for illegal access to WMD components, which opens up new options, for instance, to the manufacture of the so-called “dirty bomb” and “bomb in the garage”. The growth of international tension not only complicates the coordinated solution of socio-economic problems in the poorest countries of the world, but also contributes to their aggravation, thereby creating conditions for a significant increase in migration flows to the most developed countries. As a result, in these countries and in the world as a whole, prerequisites are created for replenishing the ranks of terrorists. Сoordination of actions of states and international institutions, enhancing the effectiveness of the NPT regimes, of already cooperatively developed and promising measures to combat terrorism can significantly reduce this threat. Without scaling down the level of confrontation between Russia and the West, the possibility of effective collective action in this direction is now significantly hampered. Historical experience, however, shows that deep crises can create the preconditions for a return to dialogue and increased cooperation on security issues.
Concrete and Culture: a material history
Authors: Moreno Moreno Julio César
Published: December 2022

Concrete and Culture: a material history
El concepto de edificio híbrido. Caracterización topológica como recurso de proyecto = The hybrid building concept. Topological characterisation as a project resource
Authors: Haddadi Salvador
Published: December 2022

ResumenEl concepto de híbrido se ha empleado desde finales del siglo XX para describir diversas arquitecturas con múltiples usos interrelacionados. La simplicidad de la actual definición ha generado confusión entre los híbridos y otras tipologías como los condensadores sociales, las megaestructuras arquitectónicas y los rascacielos. A esta controversia cabe sumar teorías contemporáneas que niegan la caracterización multifuncional de la arquitectura híbrida. Mediante un análisis comparativo de carácter funcional (uso), tipológico (forma), topológico (sistema) y semántico (definición verbal), se pretende esclarecer las diferencias entre los edificios híbridos contemporáneos y las otras tipologías o clasificaciones arquitectónicas. Esto permitirá obtener una definición actualizada del concepto de edificio híbrido, así como corroborar la hipótesis de la caracterización topológica de los edificios híbridos contemporáneos. Más allá de obtener una definición categórica, se pretende evidenciar un método de diseño y exponer la hibridación arquitectónica como estrategia o herramienta de proyecto.AbstractThe hybrid building concept has been used since the end of the 20th century to describe architectures with multiple interrelated uses. The simplicity of the current definition has led to confusion among the hybrid and other typologies, such as social condensers, architectural megastructures and skyscrapers. In addition to this controversy, we must take note the contemporary theories that reject the multifunctional characterisation of hybrid architecture. Through a comparative analysis of functional character (use), typology (shape), topology (system) and semantics (verbal definition), the intention is to clarify differences between contemporary hybrid buildings and other typologies and architectural classifications. It will provide an updated definition of the hybrid building concept and will verify the topological characterisation of contemporary hybrid buildings. Beyond achieving a categorical definition, the idea is to evince a design method and present architectural hybridisation as a strategy or project tool.
Achieving employee environmental performance through perceived organizational support towards the environment: a mediated-moderation analysis
Authors: Setyaningrum Retno Purwani
Published: December 2022

Purpose – This study aims to examine the effect of perceived organizational support for the environment (POSE) on environmental performance, by considering the mediating role of organizational citizenship behavior for the environment (OCBE) and the moderating role of individual green values.
Design/methodology/approach – This study used a quantitative approach with a sample of 215 respondents from manufacturing company employees and used purposive sampling technique. The data obtained were analyzed using conditional process analysis and SPSS-Process.
Findings – The results of this study indicated that POSE had a positive effect on environmental performance and proved that this influence can be found through the mediating role of OBCE. Then, the individual green value moderated the effect of POSE on OCBE, and the indirect effect of POSE on environmental performance through OCBE.
Research limitations/implications – The data in this study were only taken from one city in Indonesia in a cross-sectional manner; thus, it required research with longitudinal data to explore causality between variables.
Practical implications – The findings of this study can be a consideration for managers in manufacturing companies to understand the importance of improving environmental performance in companies and what factors influence it.
Originality/value – Research that uses POSE and OCBE as factors that determine environmental performance in manufacturing companies, especially in Indonesia, is still limited. In addition, this study also considers the moderating role of individual green values and contributes to provide an understanding of the importance of environmental aspects for companies.
Mujeres Libres: anarcofeminismo e subjetividade na Revolução Espanhola
Authors: Rago Margareth
Published: December 2022

Partindo das questões levantadas pelas teóricas feministas Rosi Braidotti e Elizabeth Grosz, procuro pensar a experiência das militantes anarquistas ligadas ao Grupo Mujeres Libres, durante a Revolução Espanhola, entre 1936-39. Radical em sua contestação do poder de classe e de gênero, o Grupo reuniu mais de quarenta mil afiliadas por toda a Espanha, criou cursos de capacitação das trabalhadoras, creches, postos de saúde para as mulheres e “liberatórios de la prostitución”, e publicou uma revista feminista. Considerando essa ampla experiência política, documentada nos  jornais libertários espanhóis, nos treze números da revista Mujeres Libres e em relatos autobiográficos, pergunto se e como o anarcofeminismo praticado por elas criou um modo específico de existência, mais integrado e humanizado; se e como pode operar no sentido de reatualizar o imaginário político e cultural de nossa época. Os operadores conceituais e as problematizações de Michel Foucault sobre a produção da subjetividade são referências fundamentais nessa abordagem.
Stoljeće švedske demokracije
Authors: Havel Boris
Published: December 2022

Cilj je ovoga članka kroz povijesni pregled prikazati politički sustav Kraljevine Švedske, koji se ubraja među najstabilnije na svijetu. Švedska je politika tijekom većeg dijela demokratske povijesti bila obilježena nadmetanjem dvaju blokova: lijevim kojega su predvodili socijaldemokrati i desnim ili građanskim kojega je predvodila Stranka umjerenih. Ta je tradicionalna podjela na dva bloka prekinuta 2010. kad je stranka Švedskih demokrata, koja je nastala iz ekstremističkih desničarskih pokreta, prvi put ušla u Riksdag. Njihovo prerastanje u parlamentarnu stranku te susljedni rast do treće, a 2022. do druge najveće parlamentarne stranke može se smatrati najvećim potresom suvremene švedske politike. Ovo je istraživanje usredotočeno na nastanak i uspon Švedskih demokrata, te način na koji su na neko vrijeme poremetili tradicionalni dvoblokovski sustav. Na temelju njihova stranačkog programa, političkog postupanja, reakcija čelnika drugih stranaka, te društvenih previranja koja su dovela do tako snažnog porasta, razmotreno je može li se smatrati da su se Švedski demokrati preobrazili u srednjostrujašku konzervativnu stranku, te može li se pretpostaviti da se švedska parlamentarna politička pozornica ponovno vratila u okvire dvoblokovskog nadmetanja.
Poduzetnici ili križari javnih politika?
Authors: Mikašinović-Komšo Matej
Published: December 2022

Rad analizira i kritički razmatra političko-ekstremističke zajednice na primjeru /pol/ (Politically Incorrect) zajednice s internetskog foruma 4chan, smještajući je unutar teorijskog modela višestrukih tokova te ispitujući njezinu potencijalnu prirodu kao poduzetnika javnih politika. Primjenjuje se eksploratorna kvalitativna analiza političkih ciljeva, motivacije te metoda djelovanja /pol/ zajednice u /pol/ objavama, s ciljem utvrđivanja njezine uloge unutar toka problema, toka javnih politika i političkog toka. Iako analiza ukazuje na sličnost /pol/ zajednice s poduzetnicima javnih politika, u pogledu istaknute predanosti i reputacije, te sposobnosti mijenjanja političke svijesti i percepcije javnosti unutar tokova problema i politike, /pol/ zajednica se pokazala akterom nemoćnim kultivirati veze s formalnim akterima i predlagati ideje unutar toka javnih politika, zbog čega ih se ne može smatrati poduzetnicima javnih politika. Međutim, specifična politička motivacija koja teži razaranju liberalno-demokratskog političkog sustava čini /pol/ zajednicu drugačijim oblikom aktera unutar modela višestrukih tokova – križarom javnih politika, a u širem idejnom kontekstu modela, trovačem primordijalne juhe javnih politika. Takav akter ne pristaje na kompromise, agresivno širi svoje viđenje problema te nameće svoje vrijednosti javnosti, što ga čini potencijalno opasnim za stabilnost političkog sustava.
Insajderi ili autsajderi građanstva?
Authors: Baričević Vedrana
Published: December 2022

U radu se analiziraju politike državljanstva i imigracije u Hrvatskoj, s posebnim osvrtom na etnifikaciju i marketizaciju građanstva koja se odvija u posljednja tri desetljeća. Studija polazi od koncepta građanstva kao "diferenciranog članstva" koji pretpostavlja da su beneficije članstva nejednako raspoređene među različitim subjektima građanstva neovisno o njihovom formalnom državljanskom statusu i često u suprotnosti s dominantnim nacionalnim mitologijama. Po modelu Rogersa Brubakera i njegovog koncepta "socijalnog zatvaranja", studije državljanstva u Hrvatskoj dosad su se bavile problematikom etniciteta i formalnog članstva. Pri tome, etnicitet se poima kao ključna kategorija koja pretpostavlja stjecanje državljanstva i građanskih prava. Nasuprot tome, slijedeći pristup Brigdet Anderson, u ovom radu na etničko državljanstvo gledam kao političku strategiju kojom se održava mit da sudjelovanje u naciji nosi jasne simboličke i materijalne koristi članstva. Ovaj rad nastojat će pokazati da procesi komodifikacije djeluju protiv logike etnonacionalizma pa se građanska prava rastaču u korist tržišta, a na štetu ciljanih socioekonomskih skupina unutar (etno)nacionalne većine i manjina. Socijalno građanstvo koje Brubaker i literatura "socijalnog zatvaranja" zanemaruju kritično je za razumijevanje građanstva kao koncepta i društvene prakse.
Spin-Orbital Coupling and Conservation Laws in Electromagnetic Waves Propagating through Chiral Media
Authors: Lee Hyoung-In
Published: December 2022

We examine here characteristics of electromagnetic waves that propagate through an unbounded space filled with a homogeneous isotropic chiral medium. Resulting characters are compared to those of the electromagnetic waves propagating through an achiral free space. To this goal, we form energy conservation laws for key bilinear parameters in a chiral case. Due to a nonzero medium chirality, conservation laws turn out to contain extra terms that are linked to the spin-orbit coupling, which is absent for an achiral case. As an example, we take a plane wave for achiral case to evaluate those bilinear parameters. Resultantly, the conservation laws for a chiral case are found to reveal inconsistencies among several bilinear parameters that constitute the con-servation laws , thereby prompting us to establish partial remedies for formulating proper wave-propagation problems.
Using Machine Learning to Improve Performance of a Low-Cost Real-Time Stormwater Control Measure
Authors: Khosravi Marzieh , Baghalian Sara , Burns Michael , Welker Andrea L. , Golub Michael
Published: December 2022

The alteration of natural land cover to impervious surfaces during development increases stormwater runoff. Stormwater Control Measures (SCMs) are used to manage water quantity and enhance water quality by restoring the hydrologic cycle altered by development. Often, SCMs have an outflow pipe to handle overflows or to manage the release of water detained when infiltration is not possible. Traditionally, these are static controls (e.g. a small orifice is used to restrict the volume of outflow), however, these systems can be improved by instituting real-time controls (RTC). RTC improve the functionality of SCMs by dynamically controlling outflows to adjust to environmental conditions. A major impediment to the widespread implementation of RTC is the high cost of installation and operation. This study utilized machine learning methods to develop a forecasting approach for the implementation of low-cost RTC that were implemented on a programmable gate of the outlet structure of a multi-stage basin in southeastern Pennsylvania. The goals were to decrease the peak flow exiting the basin during rain events, increase the volume of water detained, decrease the number of overtopping events, maintain healthy vegetation in the basin, and protect the downstream vegetation from erosion. Multiple popular data science algorithms were evaluated including multiple linear regression and long short-term memory. These algorithms were used with a dataset, which consisted of four years of historical sensor data, collected in 5-minute intervals, to train models to predict water levels to optimize operations. The accuracy of 30 models with three different methods of handling missing values were compared. A long short-term memory model configured with a 30-minute lead time produced the best results. Having an approximate same lag time of 30 minutes for the contributing drainage area of the SCM provided a sufficient RTC functioning period to improve the performance of the outlet structure.
Antioxidant Enzyme and Cytochrome P450 activities are involved in horseweed (Conyza sumatrensis) Resistance to Glyphosate
Authors: Kubis Gabrielly Cristina , Marques Raizza Zorman , Kitamura Rafael Shinji Akiyama , Barroso Arthur Arrobas Martins , Juneau Philippe , Gomes Marcelo Pedrosa
Published: December 2022

The intensive global use of glyphosate has led to the evolution of glyphosate resistant (GR) weed species, including the economically damaging horseweed (Conyza sumatrensis). We evaluated the glyphosate resistance mechanisms of C. sumatrensis. While 5-enolpyruvylshikimate-3-phosphate synthase activity was similar between the glyphosate resistant (GR) and nonresistant biotypes, plants from the GR population accumulated lower shikimate levels than susceptible ones, suggesting the absence of target-site resistance mechanisms. Decreases over time in glyphosate concentrations in GR leaves were not accompanied by increases in glyphosate concentrations in their stem and roots, indicating lower glyphosate distribution rates in GR plants. The early appearance of aminomethylphosphonic acid (the main glyphosate metabolite) in leaves, as well as its presence only in the stems and roots of GR plants, suggests faster glyphosate metabolism in GR plants than in susceptible ones. GR plants treated with glyphosate also showed greater antioxidant (ascorbate peroxidase [APX] and catalase [CAT]) and cytochrome P450-enzyme activities, indicating their great capacity to avoid glyphosate-induced oxidative stress. Three non-target mechanisms (reduced glyphosate translocation, increased metabolism, and increased antioxidant activity) therefore confer glyphosate resistance in C. sumatrensis plants. This is the first time that APX, CAT and P450 enzyme activities are related to GR in C. sumatrensis.
Meta-Analysis of Aquaporin Gene Family in Triticum turgidum and Its Expression Profile in Response to Salt Stress
Authors: Yaghobi Mahnaz , Heidari Parviz
Published: December 2022

During the response of plants to adverse stresses, aquaporin (AQP) plays a prominent role in membrane water transport based on received upstream signals. In addition, they have various physical parts for dealing with environmental stresses. Due to the importance of the AQP gene family, studies have been conducted investigating the function and regulatory system of these genes. However, many of their molecular aspects are still unknown. This study aims to carry out a genomic-wide investigation of the AQP gene family in durum wheat using bioinformatics tools and to investigate the expression patterns of some members in response to salt stress. Our results showed that there are 80 TtAQP genes in durum wheat, which are classified into four main groups based on phylogenetic analysis. Many duplications were observed between the members of the TtAQP gene family, and high diversity in response to post-translational modifications was observed between TtAQP family members. The expression pattern of TtAQP genes disclosed that these genes are primarily upregulated in response to salt stress. Besides, qPCR data revealed that TtAQPs are more induced in delayed responses to salinity stress. Overall, our findings illustrate that TtAQP members are diverse in terms of their structure, regulatory systems and expression levels.
Impact of Ecological Momentary Interventions on Regulatory Strategies of Perceived Stress at Work: Example With the Application "MY SHERPA” in an Ecological Context
Authors: Perreau Emilie , Belouahchi Sarah , Castel Davy , Loup-Escande Emilie
Published: December 2022

Based on ICT, specifically smartphones and their mobile apps, this exploratory study questions the impact of EMIs on employees’ perceived stress during work days. A sample of 15 workers, working at least 3 days a week - divided into one control groups (n=5) and one experimental group (n=10) - have used an EMI application “Mon Sherpa” for one-week length. Participants responded to two questionnaires at the beginning of the study: a sociodemographic questionnaire and the PSM-9 (Psychological Stress Measure). They completed the PSM-9 once again in the middle and at the end of the experiment, to compare the score’s evolution depending on the formed groups. Additionally, semi-structured interviews have been conducted with participants of the experimental group (n=9) to identify their application’s perception. Statistics results indicate no effects of the EMIs. However, interviews indicated somatic, behavioral, and cognitive evolutions throughout the experiment in the field of stress, anxiety, and invasive thoughts. These conflicting results might be explained by an immediate but not lasting effect of EMI’s on work-related stress. It may also be partly explained by some limitations of the study. More cross-disciplinary and larger research is required.
Interplay of Hydropathy and Heterogeneous Diffusion in the Molecular Transport Within Lamellar Lipid Mesophases
Authors: Bosch Antonio M. , Assenza Salvatore
Published: December 2022

Lipid mesophases are being intensively studied as potential candidates for drug-delivery purposes. Extensive experimental characterization has unveiled a wide palette of release features depending on the nature of the host lipids and of the guest molecule, as well as on the environmental conditions. However, only few simulation works have addressed the matter, which hampers a solid rationalization of the richness of outcomes observed in experiments. Particularly, to date there are no theoretical works addressing the impact of hydropathy on the transport of a molecule within lipid mesophases, despite the significant fraction of hydrophobic molecules among currently-available drugs. Similarly, the high heterogeneity of water mobility in the nanoscopic channels within lipid mesophases has also been neglected. To fill this gap, we introduce here a minimal model to account for these features in a lamellar geometry, and systematically study the role played by hydropathy and water-mobility heterogeneity by Brownian-dynamics simulations. We unveil a fine interplay between the presence of free-energy barriers, the affinity of the drug for the lipids, and the reduced mobility of water in determining the net molecular transport. More in general, our work is an instance of how multiscale simulations can be fruitfully employed to assist experiments in release systems based on lipid mesophases.
A Novel Technique for Ultrathin Inhomogeneous Dielectric Powder Layer Sensing Using a W-Band Metasurface
Authors: Kurland Zachary Austin , Goyette Thomas , Gatesman Andy
Published: December 2022

A novel technique using a W-band metasurface for the purpose of transmissive fine powder layer sensing is presented. The proposed technique may allow for the detection, identification, and characterization of inhomogeneous ultrafine powder layers which are effectively hundreds of times thinner than the incident wavelengths used to sense them. Such a technique may be useful during personnel screening processes (i.e., at an airport) and in industrial manufacturing environments where early detection and quantization of harmful airborne particulates can be a matter of security or safety. To our knowledge, the requisite science involved in such a novel W-band metasurface sensing technique has not been fully explored.
Insights of Endocytosis Signaling in Health and Disease
Authors: Pathak Chandramani , Vaidya Foram U. , Waghela Bhargav N. , Jaiswara Pradeep Kumar , Gupta Vishal Kumar , Kumar Ajay , Rajendran Barani Kumar , Ranjan Kishu
Published: December 2022

Endocytosis in mammalian cells is a fundamental cellular machinery that regulates vital physiological processes, such as the absorption of metabolites, release of neurotransmitters, hormonal secretion, cellular defense, and delivery of biomolecules across the plasma membrane. A remarkable characteristic of the endocytic machinery is the sequential assembly of the complex proteins at the plasma membrane followed by transportation of various cargo molecules to different cellular compartments. In all eukaryotic cells, functional characterization of endocytic pathways is based on dynamics of the protein complex modules. To coordinate the assembly and functions of the numerous parts of the endocytic machinery, the endocytic proteins interact significantly within and between the modules. Clathrin dependent and independent endocytosis, caveolar pathway and receptor mediated endocytosis have been attributed in a greater variety of physiological and pathophysiological roles such as, autophagy, metabolism, cell division, apoptosis, cellular defense, and intestinal permeabilization. Notably, any defect or alteration in the endocytic machinery results in the development of pathological consequences associated with human diseases such as cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases. In this review, an in-depth endeavor has made to illustrate the process of endocytosis, and associated mechanisms describing pathological manifestation associated with dysregulated endocytosis machinery.
Carbon Ink Characterization from Banana and Cassava Peels by Carbonization Method
Authors: Fatimah Siti , Mustika Nimas , Pratiwi Suci
Published: December 2022

Banana and cassava plants are the most growing plants in the world. The use of both plant's peel is usually for animal feed. This research is intended to utilize banana and cassava peel as a raw material of whiteboard ink markers by varying concentration of the carbons to see its effect on the characteristics of the ink.  The carbon concentration variations are 25 g, 30 g, 35 g, 40 g, and 45 g, which is dissolved in 100 ml of the solution. The steps of this research include the carbonization of banana or cassava peel, and then its carbon powder is sifted by 200 mesh. The powder will be dissolved in 50 ml of Arabic gum 10%, 15 ml of PEG-7, and 35 ml of alcohol 70%, then the solution stirred until homogeneous. The result showed that the addition of the Banana or cassava peels carbon concentration effect on the value of density, viscosity, pH, and pigment ink. The characteristic whiteboard ink markers from the banana peel that accordance with the commercial ink. It is consists of 30% Banana peel carbon concentration with a density value of 1.0077 g/cm3, viscosity value of 6.2049 cP, pH value of 10.55, and the ink pigment are close enough with the commercial refill ink. While the characteristic from cassava consists of 35% cassava peel carbon concentration with a density value of 1.0893 g/cm3, viscosity value of 15,2427 cP, pH value of 8,75, and the ink pigment are close enough with the commercial ink
Implementation of Scaffolding in Project Based Learning Model to Improve Skills of Science Process in Buffer Solution Material
Authors: Haryati Tri , Gusti Diah Riski , Hasibuan Muhammad Haris Effendi , Rusdi Muhammad
Published: December 2022

Dynamic assessment, which is supported by scaffolding, consists of questioning, prompting, cueing, and explaining. Scaffolding is considered as an effort to overcome learning problems which present in the concept of buffer solution as well as in the Project-based Learning, which aims to improve students' science process skills. This study aims to investigate the implementation of scaffolding to improve students' science process skills about the concept of buffer solution. Data were collected using in-depth interviews and analyzed using the Delphi technique. Based on the results of the analysis, it can be seen that the ideal scaffolding widely used was the questioning and the prompting. This was because the students only needed to be guided to solve the problems using the most appropriate assistance to overcome the issues. Therefore, it can be concluded that the implementation of the scaffolding was able to help the students to overcome the problems that occur during the learning process. The implementation was also able to improve the students' understanding and skills of the science process about the concept of buffer solution.
Implementation of The Video Project with Distance Learning on The Basic Chemistry Course
Authors: Setiowati Hanifah , Harahap Lenni Khotimah , Mardhiya Julia
Published: December 2022

Education in the 4.0 era encourages the use of digital technology in a sustainable learning process. This article tries to analyze student responses to implementing a video project in a basic chemistry course. This research is qualitative research with a survey method. The participants were 74 students of the Chemistry Education Study Program and Mathematics Study Program consisting of 8 male students and 66 female students. Data collection techniques using online questionnaires by google form application. The steps in this study are  Search for instrument literature to be compiled on the google form, compile a google form student response to the implementation of the video project, distribute the google form questionnaire link to students, and analyze the data obtained. The results showed that students positively responded to the implementation of the video project in terms of autonomy, teamwork, and technology used. The implementation of video projects improves learning skills, collaboration, and digital literacy independently, although students experience problems in video editing because they are not used to using these.
Development of Authentic Assessment Based on Creative Thinking Skills in A Carbohydrates Qualitative Analysis Project-Based using Local Material
Authors: Sari Diah Kartika , Sufiana Jejem Mujamil , Wancik K. Anom , Haryani Maefa Eka
Published: December 2022

Laboratory activities can improve creative thinking skills. This study aims to develop an authentic assessment based on creative thinking skills. This research is development research with the Rowntree development model. The research stages consist of the planning stage, the development stage and the evaluation stage. Data were analyzed using CVR and test description. This study was conducted with 33 participants. This research has produced an authentic assessment instrument consisting of learning indicators, written tests, test rubrics, product rubrics and psychomotor assessment rubrics. An authentic assessment developed in the qualitative analysis of carbohydrates with a CVR value obtained is +0.70, which can be considered valid for all validated components. The authentic assessment reliability test resulted in an average score of 56.56, a standard deviation of 25.06, and test reliability of 0.82. from the analysis, it was determined that the authentic assessment based on creative thinking skills of qualitative analysis of carbohydrates with local material developed had met the valid and reliable criteria.

 
Synthesis of Na-CMC Modified Cellulose Membrane From Water Hyacinth (Eichhornia Crassipes) Rods Against Cr (VI) Metal Adsorption
Authors: Nafi'ah Rohmatun , Rosyidah Siti
Published: December 2022

Metal ion Cr (VI) is a type of heavy metal waste that is dangerous, so we need a method to reduce the level of pollution. The separation method using a cellulose membrane is an effective method to reduce the level of Cr (VI) metal pollution, by utilizing natural materials such as water hyacinth plants which are known to contain high enough cellulose. The purpose of this study was to determine the effect of concentration variations with time variations on the adsorption capacity of Cr (VI) metal ions from Na-CMC modified cellulose membranes from water hyacinth (Eichhornia crassipes) stems. This research uses experimental research methods, the steps that have been carried out are sample treatment, extraction, bleaching, hydrolysis, Na-CMC modified cellulose membranes. Data analysis was performed by sample characterization test using the FTIR Spectroscopy method and for metal content analysis using the Atomic Absorption Spectrophotometer (AAS) method. The results showed that there was an effect of concentration variations and time variations on the adsorption capacity of Cr (VI) metal ions. At the concentration variation with the largest adsorption capacity of 1.24 mg/gram occurred at a concentration of 30 mg/L and at the time variation the largest adsorption capacity of 0.917 mg/gram occurred at 30 minutes. The results respectively of FTIR showed functional groups O-H, C-H, and C-O in non-modified cellulose and there was no significant effect after the addition of Na-CMC, as evidenced by the similar FTIR spectrum without any shift or new peaks appearing. 
BAGAIMANA LOYALITAS KARYAWAN BERDASARKAN GAYA KEPEMIMPINAN PADA HOTEL X?
Authors: Milasari Desita , Doriza Shinta , Mashabi Nurlaila A
Published: December 2022

Gaya kepemimpinan merupakan salah satu faktor yang membuat karyawan berkeinginan untuk melakukan perpindahan atau resign. Ketidak nyamanan dalam bekerja, ketidak cocokan dengan pemimpin, ataupun  tekanan yang diberikan oleh pemimpin yang  kemudian akan menghambat kinerja karyawan. Dengan demikian, operasional hotel juga ikut terganggu. Sebaliknya pemimpin yang dapat menjalin hubungan baik dengan karyawan dalam urusan pekerjaan maupun di luar pekerjaan akan membuat karyawan merasa adanya kecocokan serta timbul rasa nyaman, dan besar kemungkinan karyawan memiliki rasa loyalitas terhadap pemimpinnya yang membuat karyawan terdorong untuk ikut berperan secara maksimal memberikan yang terbaik bagi tempatnya bekerja bersama pemimpinnya. Hal ini dikarenakan timbulnya rasa tidak ingin mengecewakan orang yang telah memberinya tempat nyaman dalam bekerja. Penelitian dilakukan untuk menganalisis loyalitas karyawan yang ditinjau dari gaya kepemimpinan di Hotel X. Metode penelitian ini adalah penelitian deskriptif kualitatif. Teknik pengumpulan data menggunakan wawancara mendalam melalui perspektif dari pemimpin dan karyawan pada tiga departemen yang berbeda, perspektif yang dipilih bertujuan untuk menemukan temuan yang lebih menarik yang dilihat dari dua sisi. Pemilihan responden dengan purposive sampling. Analisis data menggunakan interactive model. Data penelitian mengacu pada sembilan karakteristik ideal dari (Putra & Cho, 2019), hasil dari penelitian ini menunjukkan bahwa ada beberapa karakteristik ideal yang belum dipenuhi oleh salah satu responden pemimpin, sedangkan responden pemimpin lainnya menunjukkan hasil hampir dan sudah memenuhi sembilan karakteristik sebagai pemimpin ideal. Belum terpenuhinya kesembilan karakteristik ideal ini berdampak pada kurangnya rasa loyalitas karyawan pada perusahaan dilihat dari tingkat perpindahan karyawan yang tinggi pada departemen sehingga mengakibatkan banyak kerugian bagi perusahaan.
EFEKTIVITAS PENGGUNAAN SCHOOLOGY DAN ZOOM CLOUD MEETING SEBAGAI MEDIA PEMBELAJARAN JARAK JAUH PADA MATA KULIAH DEKORASI & PENATAAN (AMERICAN SERVICE)
Authors: Siti Triyaningsih
Published: December 2022

Penelitian ini bertujuan untuk mengetahui efektivitas dari penggunaan media Schoology dan Zoom Cloud Meeting terhadap pembelajaran jarak jauh pada mata kuliah Dekorasi dan Penataan (American Service). Populasi dalam penelitian ini seluruh mahasiswa pendidikan kesejahteraan keluarga angkatan 2020 yang terdiri 93 mahasiswa. Sampel penelitian ini yaitu mahasiswa pendidikan kesejahteraan keluarga angkatan 2020 yang dipilih dua kelas masing-masing terdiri dari 30 mahasiswa. Metode yang digunakan dalam penelitian ini Quasi Experiment dengan desain penelitian Pretest dan Pos test Control Group Design. Teknik pengambilan data menggunakan tes yaitu pretest dan post-test. Teknik analisis data yang digunakan yaitu uji normalitas Kolmogorov-Smirnov dengan taraf signifikan 0,05 maka dtabel= 0,242. Hasil penelitian dengan uji t dan N-Gain, pertama terdapat pengaruh dari media Zoom Cloud Meeting dan Schoology terhadap hasil belajar mahasiswa. Nilai sig pada kelas eksperimen menunjukkan thitungttabel (9>1,679) maka H0 ditolak dan Hi diterima. Pada taraf signifikansi = 0,05 pada dk= (n1+n2)-2= 60-2= 58 pada dua pihak, diperoleh nilai ttabel= 1,671 yang menyatakan bahwa terdapat perbedaan rerata hasil sehingga menunjukkan bahwa Schoology lebih efektif dibandingkan dengan Zoom Cloud Meeting. Hasil penelitian menunjukkan penggunaan media Schoology dapat diterapkan pada mata kuliah praktikum yang ada di Program Studi Pendidikaan Kesejahteraan Keluarga.

Kata Kunci: Media Pembelajaran, Schoology, Zoom
PERILAKU KONSUMSI KOPI SEBAGAI BUDAYA MASYARAKAT DI KEDAI KOPI STARBUCKS MAL ARTHA GADING
Authors: Tania Catherine , Hurdawaty Ramon
Published: December 2022

Pada awalnya mengkonsumsi kopi merupakan kegiatan orang dewasa untuk mengisi waktu luang atau untuk memberi tenaga sebelum bekerja. Namun kini telah berubah menjadi kebiasaan anak remaja, mereka mengikuti budaya asing dan menjadikan gaya hidup modern. Gaya hidup disini adalah aktivitas konsumsi kopi. Aktivitas minum kopi telah menjadi gaya hidup, tidak hanya sebagai tempat untuk bertemunya anak-anak muda, tetapi juga terletak pada varian menu kopi yang lebih mahal dari kedai kopi biasanya, dan disebut perilaku konsumtif. Di Jakarta, kedai kopi mudah ditemukan diberbagai tempat, seperti di supermarket, di mall, bandara, dan stasiun. Seperti Starbucks, Starbucks Coffee merupakan salah satu kedai kopi yang memiliki arti prestise yang tinggi bagi konsumen karena harganya yang cukup mahal. Metode penelitian yang digunakan dalam penelitian ini adalah deskriptif kualitatif melalui observasi, wawancara, dan dokumentasi. Penelitian ini menggunakan teknik purposive sampling. Pengambilan sampel ditentukan dengan pelanggan yang datang ke Starbucks dan memesan kopi. Berdasarkan hasil penelitian menunjukkan bahwa budaya masyarakat telah berkembang, Fenomena yang terjadi menunjukkan bahwa kedai kopi merupakan salah satu gaya hidup zaman sekarang. Dimana kedai kopi merupakan tempat yang memfasilitasi banyak orang untuk terlibat dalam kegiatan, minat, dan pendapat seseorang untuk menciptakan gaya hidup anak muda saat ini.