bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictive factors for CPAP failure in obstructive sleep apnea patients
Authors: Goyal Abhishek , Joshi Ankur , Mitra Arun , Khurana Alkesh , Chaudhary Poonam
Published: October 2021

Objectives:

Some patients with obstructive sleep apnea (OSA) do not respond to Continuous Positive Airway Pressure (CPAP) and for these patients, Bi-level PAP is the next level modality. This study by a theory driven hierarchical approach, tries to identify the predictors for CPAP failure among OSA patients.

Methodology:

The potential predictors for the model were identified from a theoretical framework rooted in clinical examination, laboratory parameters, and polysomnographic variables pertaining to OSA patients. All patients of OSA who underwent manual titration with CPAP or Bi-level PAP (in case of CPAP Failure) between June 2015 and October 2017 were included in model building. This study compared five competitive models blocks deliberated by increasing order of diagnostic complexity and availability of resources. The fitting of the model was determined by both internal and external validation.

Results:

Among the five competitive models, the selected model has the significant deviance reduction (−2LL = 121.99, X
2 = 25.55, P < 0.0001) from the baseline model (−2LL = 217.356). This logistic regression model consists of the following binary predictors – Age >60 years (odds ratio [OR] = 3.23 [1.27–8.23]), body mass index >35 Kg/m2 (OR = 4.25 [1.78–10.13]), forced expiratory volume <60% (OR = 7.33 [2.83–18.72]), apnea-hypopnea index >75 (OR = 4.31 [1.61–11.56]) and T90 > 30% (OR = 6.67 [2.57–17.36]).

Conclusion:

These five factors (acronym as BIPAP) may aid to the clinical decision-making by predicting failure of CPAP and therefore may assist in more vigilant clinical care.
Delirium and its Pharmacological Causes in Older People, Part Two
Authors: DeMaagd George A. , DeMaagd Daneen R. , Philip Ashok
Published: October 2021

Delirium is a syndrome that can arise from many causes or underlying conditions, and though it has been reported in younger patients, it is more prevalent in older people, though it can occur in other age groups as well. Identifying delirium is challenging in older people because of the coexistence of underlying dementia or depression, which may further complicate the presentation. Drug-induced delirium is one of the major causes of delirium, and evaluation of this potential cause or contribution is an important component of the evaluation process, since it can lead to poor patient outcomes. Part one of this three part series reviewed the epidemiology, pathophysiology, evaluation, diagnostic process, and causes of delirium in older people, with a focus on the pharmacological causes. Part two of this series continues to review drugs and drug classes that can cause or contribute to delirium in older people.
The Use of Continuous Glucose Monitoring in Older People With Type 2 Diabetes
Authors: Rao Hindu , Fakourfar Neeloufar , Sun Caroline , Lewis Jelena
Published: October 2021

Objective To review current guidelines and literature regarding continuous glucose monitoring (CGM) use in the management of type 2 diabetes mellitus (T2DM) in older people. Data Sources A PubMed search of articles published through August 2020 using a
combination of the following: older people, T2DM, continuous glucose monitoring, hypoglycemia, and hyperglycemia. Study Selection/Data Extraction Relevant randomized control trials, meta-analyses, and guidelines were assessed for the use of CGM in older patients with T2DM.
Articles were included based on relevance to the topic, detailed methods, and complete results. Data Synthesis CGM use in T2DM management in older people is not well defined. CGM may be a valuable technology in older people who face unique challenges, such as hypoglycemia,
decline in cognitive function, and variable glucose levels. This article provides a review of recommendations for glucose monitoring in T2DM and discusses the role of specific CGM products. Conclusion CGM is a viable option for older people with T2DM to help improve overall
diabetes control. Pharmacists can play an important role in educating patients about this technology.
Динамика пространственно-распределенных в двумерной области
цепочек связанных систем уравнений
Authors: Кащенко Сергей Александрович , Kaschenko Sergey Aleksandrovich
Published: October 2021

В двумерной области изучается локальная динамика связанных одинаковых нелинейных
систем дифференциальных уравнений второго порядка. Основное предположение состоит
в том, что количество таких уравнений является достаточно большим. Это дает
возможность перейти к системе с двумя непрерывными пространственными переменными.
Выделены критические случаи в задаче об устойчивости состояния равновесия. Все
они имеют бесконечную размерность, т.е. бесконечно много корней
характеристического уравнения для линеаризованной задачи стремятся к мнимой
оси при стремлении к нулю естественного малого параметра. Построены специальные
нелинейные уравнения в частных производных, нелокальная динамика которых описывает
поведение исходной системы в окрестности состояния равновесия, которое играет роль
нормальной формы.
Особо отметим, что построенные системы в частных производных содержат четыре
пространственные переменные с краевыми условиями по каждой из них.
Библиография: 24 названия.
Africa’s COVID-19 third wave: A coupled behavior-disease system in a mutual feedback loop
Authors:   Center for International Health, University of Munich (LMU), Germany, Kangbai Jia Bainga , Sheku Mahmoud ,   Institute for Global Health, University of Siena, Italy, Koroma Braima ,   Sierra Leone Urban Research Center, Sierra Leone, Macathy Joseph Mustapha ,   Department of Geography, Njala University, Kaitibi Daniel ,   Njala University, Sierra Leone, Sahr Foday ,   The National COVID Emergency Response Centre (NACOVERC), Sierra Leone, George Angella Magdalene ,   Department of Nursing, Njala University, Sierra Leone, Gegbe Fatmata ,   Department of Nursing, Njala University, Sierra Leone, Cummings-Wray Daphne ,   Department of Nursing, Njala University, Sierra Leone, Babawo Lawrence Sao ,   Department of Nursing, Njala University, Sierra Leone
Published: October 2021

A year after COVID-19 was declared a pandemic much of the Africa continent started experiencing spikes in the number of COVID-19 cases and related deaths in what was referred to as the third wave of the pandemic. These spikes came right behind the heels of a second wave of the pandemic that barely went unnoticed in Africa. As of July 2021, Morocco, South Africa, Tunisia, Egypt, Nigeria, Libya, Kenya, Algeria, Zambia and Ethiopia accounted for approximately 86% of the reported increase in COVID-19; these countries were aptly described as being at the forefront of the continent’s third wave of the COVID-19 pandemic. Unlike those countries in Asia and Latin America that experienced what may generally being described as autochthonous COVID-19 third wave, Africa’s third wave COVID-19 cases are widely believed to have been triggered by imported cases. Africa like the rest of the world relaxed its COVID-19 restrictions almost at the same time; hence the continent’s spikes of COVID-19 cases and related deaths during the third wave of the pandemic have raised some questions.
Ideology in Polish Translations of Anglo-American Literature
Authors: Marcinkiewicz Paweł
Published: October 2021

Ideology has always influenced translation, yet this fact became a topic of scholarly research only in the 1990s. The working of ideology in literary translations most often manifests itself as a conflict of value systems. From vast reservoir of foreign sources, the native axiology absorbs values that it needs to sustain its culture. It is not a coincidence that Anglo-American literature, propagating ideas of democracy and individual freedom, became popular in Poland in the first half of the nineteenth-century when Poland did not exist as a state. Only a century later, American literature was the most popular of all foreign literatures in pre-1939 Poland. World War II changed this situation, and the Soviet-controlled apparatchiks favored translations that were “politically correct.” Yet, because of their connections with earlier revolutionary movements, avant-garde Anglo-American writers were often published during the communist regime, for example Virginia Woolf, whose novels were standardized to appeal to the tastes of popular readers. After Poland regained independence in 1989, the national book market was privatized and commercialized, and avant-garde literature needed advertising to get noticed. Cormack McCarthy’s novels were translated into Polish on the wave of popularity of the Coen brothers movie based on No Country for Old Men. The two Polish translations of McCarthy’s novel try to sound like a typical hard-boiled realistic fiction. This is where the ideology of consumerism meets the ideology of communism: literature is a means to sustain – and control – a cultural monolith, where all differences are perceived as possible threats to social order.
Methodology for the Evaluation of Machine Translation Quality
Authors: Ananyan Ani , Avagyan Roza
Published: October 2021

Along with the development and widespread dissemination of translation by artificial intelligence, it is becoming increasingly important to continuously evaluate and improve its quality and to use it as a tool for the modern translator. In our research, we compared five sentences translated from Armenian into Russian and English by Google Translator, Yandex Translator and two models of the translation system of the Armenian company Avromic to find out how effective these translation systems are when working in Armenian. It was necessary to find out how effective it would be to use them as a translation tool and in the learning process by further editing the translation.

As there is currently no comprehensive and successful method of human metrics for machine translation, we have developed our own evaluation method and criteria by studying the world's most well-known methods of evaluation for automatic translation. We have used the post-editorial distance evaluation criterion as well. In the example of one sentence in the article, we have presented in detail the evaluation process according to the selected and developed criteria. At the end we have presented the results of the research and made appropriate conclusions.
Alexander Pushkin's Winter Evening in Armenian and English Translation
Authors: Ghazaryan Ruzanna , Dadyan Ishkhan
Published: October 2021

This research dwells upon prominent Russian writer Alexander Pushkin’s poetry in light of translation. More specifically, one of Pushkin’s most famous poems – “Winter Evening” has been selected to be analyzed with regard to its translation in Armenian and English. This study aims to reveal the major challenges that the translators have faced while rendering the poem from Russian into Armenian and English as well as to disclose the discrepancies that exist between the original and the translated texts. Also, an attempt will be made to identify the major lexical, grammatical, stylistic and syntactic shifts that have occurred in the translation process in order to assess the degree of translation accuracy and pinpoint whether or not the translated texts impact the target-language readers to the same extent as the original.
Comparative Investigation of English and Armenian Compound Patterns
Authors: Karapetyan Sirarpi
Published: October 2021

The novel “The Great Gatsby” by F. Scott Fitzgerald published in 1925 is one of the timeless classics of world literature which was investigated from different linguistic perspectives. Its vocabulary is abundant in compound words with a variety of morphological, syntactic, semantic peculiarities. In this paper, we aim at studying compound words in “The Great Gatsby” to illustrate their patterns in English and Armenian. We have investigated the compounds from the morphological-categorial point of view, from the perspective of the syntactic relations between their constituent parts. We have also briefly touched upon some of their semantic features. At the same time, a close attention was paid to the different ways in which compound patterns were translated into Armenian. The study of the main target of the paper is based on Sona Seferyan's translation of the novel “The Great Gatsby” into Armenian. A lot of examples of both synthetic (closed) and analytical (juxtaposed) compounds have been picked out. In Armenian within synthetic compounds we differentiate between those with a linking element, e. g. “աշխարհամարտ” (where “ա” is the linking element) and the ones without а linking element, e. g. “արևելք”. We assume that the peculiarities of compounds revealed in this paper will have significance not only for the description of their characteristic features but also for the general typological characterization of the languages under study.
On an Armenian Translation of Seumas Macmanus’s ‘The Old Hag’s Long Leather Bag’
Authors: Jivanyan Alvard
Published: October 2021

MacManus’s The Old Hag’s Long Leather Bag is a unique text in terms of style in the first place. The study of its translation into Armenian is of interest since it is the very first Irish folk tale translated into Armenian. As many renderings of folktales of the time it is an indirect translation mediated by the Russian version. The translation of each particular folktale is of interest, however a number of features of the text, which are held to be resulting from the translator’s individual style are in fact conditioned by the nature of the translated text as a distinct text type.
A Pragmatic-Based Approach to Translation: Mi Dai?/Dammi! And Дай! In the Parallel Russian-Italian Corpus
Authors: Artoni Daniele
Published: October 2021

This essay focusses on how the knowledge of cross-cultural pragmatics can provide a theoretical background for the translation practice, especially in the search for equivalent functions. This study concentrates on the Russian and the Italian languages and on the speech act of requesting, in that not only is request amongst the most frequent speech acts, but also it is realised in different ways in the two target languages. In particular, whereas imperative is a common strategy used in Russian requests, its presence is restricted to informal bilateral requests in the Italian-speaking contexts. In order to investigate how the imperative is distributed in requests translated from Russian into Italian and vice versa, and whether such translations are appropriate from a pragmatic perspective, in our study we have analysed the occurrences of the imperative request “give (me)!” in Russian (дай!) and Italian (dammi!) in the parallel Russian-Italian corpus of the National Corpus of the Russian Language.
Abbreviations in English Shipbuilding Terminology and Their Translation into Romanian
Authors: Popescu Floriana
Published: October 2021

Abbreviations represent a substantial element in the English and Romanian word stock as well as in their shipbuilding terminologies. This paper is an analysis of the English abbreviations and their Romanian versions in an attempt to assess the availability of the latter language to shipbuilding Anglicisms. The research mainly consisted in the creation of a data bank to comprise the abbreviations that occur in English shipbuilding glossaries, dictionaries and lexicons and whose versions were included in similar Romanian lexicographic works. A first step in this project was the determination of the meanings assigned to the notion of abbreviation, which has been described to convey rather controversial meanings in English lexicology. The translational perspective of this approach was constructed on the concepts of foreignization and domestication, advanced by Venuti in the mid 1990’s. Our analysis was designed to highlight the English touch on the vocabulary of the Romanian shipbuilding terminology, at the same time disregarding both the quantitative and qualitative aspects of this influence. These aspects were waived because terminologies, like any other compartment of languages, are vivid organisms in a continual strive to develop, enrich and expand.
Foreign Direct Investment Led Growth Hypothesis and Economic Development in Nigeria
Authors: Effiong Ubong Edem , Inyang Nora Francis
Published: November 2021

This study was an inquiry into the nexus of the foreign-direct investment (FDI) led growth hypothesis, and how it translates into the development of the Nigerian economy as of 1970 – 2018. The study utilized secondary data from the ‘World Development Indicators’ which were analysed using the Bounds test for cointegration and the ‘autoregressive distributed lag (ARDL) approach to divulge both the short-term cum the long-term influence of foreign direct investment net inflow on ‘economic development’ of Nigeria. The Bounds test was conducted after the unit root test revealed that the variables were stationary at mixed order of level and first difference. The outcome of the ARDL Bounds test supported confirmation of long-term association among the variables. The ARDL short-run error correction showed that 14.62% of the instability in the model was corrected yearly. In the short-term, it was discovered that FDI wielded a deleterious and substantial weight on ‘economic development of Nigeria. Meanwhile, the long-term estimates indicated that FDI influenced economic development positively, though not in a significant manner. The Granger causality test supported the fact that FDI causes ‘economic development’ in Nigeria. Given this potential of FDI exerting a positive effect on ‘economic development’, the paper recommended that bottlenecks inherent in FDI influxes in the country should be removed so as to reap the fullest benefits of such inflows in Nigeria.
Type-2 DM and Its Complication and Relationship among the Patients at Rajshahi Diabetes Association General Hospital: Socio-demographic Characteristics
Authors: Shanta Farzana Ferdousi , Biswas Deepa
Published: November 2021

The aim of this cross-sectional study of Type-2 diabetes mellitus and its complication among the patients admitted in Rajshahi Diabetes Association General Hospital and its relationship with their socio-demographic characteristics. Total fifty (50) respondents were selected for the study. Complication of Type-2 diabetes mellitus were mainly investigated. The instrument developed by the researcher was divided into 2 sections including, 1) Demographic questionnaire. 2) Question regarding complications of type-2 diabetes mellitus patients. The main findings of this thesis are that the proportion of complication of type-2 diabetes mellitus patients. The age of the respondents which 14% were between 31-40 years of age about 30% between 41-50 years, about 40% between 51-64 years, 16% between 65-90 years. Type of family 46 (92%) were the members of nuclear family 4 (8%) were the member of joint family. This study would like to examine the respondents’ ratings of different religions who were married or divorced. Socio-economic status 74% were poor, 26& respondents were middle. For this purpose, this study would like to investigate the complication of type 2 diabetes mellitus patients; the ratings of nephropathy, hypertension, the loss of sensation, heart problem, homeopathy, and Kobiraji treatment.
C-Reactive Protein Levels and its Association with Acute and Chronic Inflammatory Diseases- An Observational Study
Authors:   Research Associate, Viral Research and Diagnostic Laboratory, Govt. Medical College, Amritsar, Punjab, India, Bharti Aashish
Published: October 2021

Background: C-reactive protein is a nonspecific, acute-phase, inflammatory protein, whose expression is increased in response to tissue injury, inflammation and infection. The highest concentrations of CRP are found in an individual having some bacterial infections where CRP level increase up to 1,000-fold. The present study was undertaken to determine the C-reactive protein levels in clinically suspected OPD and IPD patient by Latex agglutination test (LAT). Material and Methods: Blood samples were collected from clinically suspected OPD and IPD patients with signs of inflammation in plain vacutainer tubes and received in Serology laboratory of Microbiology Department for CRP testing. All blood samples were screened by Qualitative CRP assay by using commercially available kit. Blood samples that were positive were further tested for CRP titre by semi-quantitative test using same kit (Beacon Diagnostics Pvt Ltd ). Results: A total of 450 serum samples were received for CRP testing during a period of six months. Higher CRP levels were obtained in patients with chronic inflammatory diseases (76%) and as compared to patients with acute inflammatory diseases (24%). Conclusion: CRP is an inexpensive and easily available serological test helpful in correlating severity and mortality of any disease. Early CRP testing can be a very helpful tool to improve the clinical outcomes of patients and decreased mortality.
AMEFRICANIDADES: MEMÓRIAS E ESCRITAS DE MULHERES NEGRAS
Authors: Silva Júlia Dias da
Published: October 2021

Esta escrita pretende articular memória e história, destacar a produção literária de mulheres afrodiaspóricas e ressaltar a figura da mulher negra que, enquanto sujeito e protagonista de sua trajetória, reconstrói e subverte discursos branco-hegemônicos. Trata-se de relacionar narrativas de passado e de presente, a partir da leitura de Um defeito de cor, de Ana Maria Gonçalves, e Jonatás y Manuela, de Luz Argentina Chiriboga. Cab ressaltar que as personagens destas obras podem ser lidas como personificações da encruzilhada de vivências e dos trânsitos que são causa e consequência de ser mulher negra nas Américas.
UMA ANÁLISE DE RÚTILO NADA SOB A PERSPECTIVA QUEER
Authors: Gomes Rita de Kássia de Aquino , Araújo Rosanne Bezerra de
Published: October 2021

O objetivo deste trabalho é investigar a condição relacional dos personagens Lucius e Lucas, em Rútilo Nada (1993), a partir da teoria queer. Apoiando-nos em autores como Judith Butler (2003), Eve Sedgwick (2007) e Richard Miskolci (2012), o estudo refletirá sobre importantes questões, como o regime de heteronormatividade, heterossexismo e heterossexualidade compulsória no qual os personagens de Hilda Hilst estão inseridos, analisando ainda a trajetória da relação em questão, bem como o seu desfecho, sob o viés dos estudos queer.
POÉTICA DAS SEXUALIDADES DISSIDENTES EM ARARIPE COUTINHO
Authors: Santana Neto Jaime , Garcia Paulo César Souza
Published: October 2021

Subestimado em Sergipe, o poeta Araripe Coutinho tornou-se um sujeito fora-de-centro ao produzir obras estranhadas de sentidos e potencializadas de subjetividades que transgridem a heteronormatividade e o patriarcado. Este trabalho visa apontar significados referentes às sexualidades dissidentes na literatura de Coutinho, considerando o primeiro livro “Amor Sem Rosto”, publicado em 1989. A pesquisa se debruça nos textos do autor que busca criar a si, usando linguagens do cotidiano que movem as relações afetivas e se constituem em signos que operam a poética queer do poeta.
O ENSINO DA LITERATURA MODERNISTA POR MEIO DE CANÇÕES
Authors: Araujo Ruan Carlos Teles de
Published: October 2021

Este trabalho apresenta uma proposta de unidade didática para o Ensino de Literatura (COSSON, 2006) destinado ao público do Ensino Médio. Tal proposta faz parte dos estudos desenvolvidos durante o Seminário ministrado pela Prof.ª Dr.ª Ana Maria Machado, em 2020, no contexto do Doutoramento em Literatura de Língua Portuguesa, pela Universidade de Coimbra. Objetiva-se destacar a atual importância das canções, como gêneros subliterários (CANDIDO, 1989; FISCHER, 2019), para um maior alcance na compreensão dos aspectos das poesias e Literatura Modernista no Brasil e em Portugal.
LITERATURA SURDA: UMA ANÁLISE CRÍTICA
Authors: Rocha Helen Cristine Alves
Published: October 2021

Atualmente, nota-se uma carência de estudos na área de literatura criada/destinada ao surdo, e contribuir com a proposta de preenchê-la é uma das tarefas deste artigo. Por isso, a pesquisa que engendramos para este trabalho tem como objetivo problematizar o que se nomeia de Literatura Surda e sugerir um novo termo (“Sinalitura”) para as criações de/para surdos. Para tal fim, sobre Literatura Surda elegemos as pesquisas de Lodenir Karnopp (2006, 2008, 2010), Cláudio Mourão (2011, 2016), Fabiano Rosa (2011) e Luiz Carvalho (2019); acerca de literatura e estética selecionamos Roland Barthes (2007), Antonio Candido (2011), Edmir Perrotti (1986) e Marta Morgado (2011); concernente à performance elencamos a obra de Paul Zunthor (2007). Entendemos que a literatura de/para surdo deve ser visualmente entendível para que ele a frua de forma autônoma.
New possibilities of pharmacotherapy for systemic lupus erythematosus: Prospects for the use of anifrolumab (monoclonal antibodies to type I interferon receptor)
Authors: Nasonov E. L. , Avdeeva A. S. , Popkova T. V.
Published: October 2021

Systemic lupus erythematosus (SLE) is a systemic autoimmune rheumatic disease of unknown etiology, characterized by overproduction of organ-specific autoantibodies to various components of the cell nucleus and the development of immune-inflammatory damage to internal organs. According to modern concepts, one of the key mechanisms of SLE immunopathogenesis is associated with dysregulation of type I interferon (IFN) synthesis The complex of data obtained in the process of fundamental and clinical research served as the basis for the development of a new approach to the pharmacotherapy of SLE, associated with the use of monoclonal antibodies (mAbs) that block the activity of IFN type I or its receptors. Among these drugs, anifrolumab (AFM) occupies a special place, which is a human IgG1 mAbs that bind to cellular receptors for IFN-α. The article discusses the materials of the main studies concerning the efficacy and safety of AFM in SLE, and the prospects for the use of this drug in the treatment of this disease.
Lyme disease: Modern approaches to prevention, diagnosis and treatment
Authors: Belov B. S. , Ananyeva L. P.
Published: October 2021

Lyme disease (LD) or tick-borne borreliosis affects thousands of people every year in different regions of the world, primarily the United States and Europe. In endemic areas, early LD is a common disease that requires high medical vigilance. Considering the extreme relevance of this problem for public health, in November 2020, the committee of experts of three American scientific societies published an updated version of the clinical guidelines for the prevention, diagnosis and treatment of LD, the main provisions of which are presented in this article. It is emphasized that in the absence of vaccines, the risk of LD and other diseases transmitted by ticks can be reduced by using personal protective equipment and repellents. Antibiotic prophylaxis is carried out by a single oral administration of doxycycline. In the laboratory diagnosis of LD, the determination of antibodies to B. burgdorfery in the blood serum is a first-line study. At the second stage, serum samples are examined using an immunoblot for IgM and IgG. The basis of treatment of LD is rational antibiotic therapy. The choice of an antibiotic depends on a number of factors, including the presence of extracutaneous manifestations of LD (neuroborreliosis, carditis, arthritis). The most commonly used are doxycycline, amoxicillin, cefuroxime-axetil and ceftriaxone.
Upper respiratory tract manifestations in patients with ANCA-associated vasculitides and their association with the presence and type of ANCA
Authors: Smirnova I. G. , Bulanov N. M. , Novikov P. I. , Osipova I. A. , Moiseev S. V.
Published: October 2021

Aim of the work – to compare the frequency of upper respiratory tract (URT) involvement in patients with ANCAassociated vasculitides (AAV), to reveal its main clinical and radiological patterns and to estimate their association with the serological profile (ANCA presence and type).Material and methods. This retrospective study evaluated 369 patients with granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA). The enrolled patients were diagnosed with AAV according to the ACR criteria, CHCC classification (2012) and EMA algorithm. Patients with URT manifestations underwent standard ENT assessment and X-ray/CT. Serum ANCA levels were measured by ELISA.Results. URT involvement was diagnosed in 280 (75.9%) patients with AAV. It was significantly more common amongthe patients with GPA (86.4%) and EGPA (85.5%) compared with the MPA group (29.2%) (p<0.001).URT manifestations mainly appeared as sinusitis (77.2% – GPA; 33.3% – MPA; 70.8% – EGPA) and rhinitis with crusting (87.8%, 72.2% and 16.9% respectively).Proteinase 3 ANCA positive patients had a significantly higher incidence of bone destructive URT lesions, including sinuses wall destruction (p<0.001) and saddle nose deformity (p=0.016), compared with myeloperoxidase-ANCA-positive patients. Similar results were obtained in the GPA group separately.Localized disease with isolated URT involvement was observed in 41.3% cases of ANCA negative GPA (p<0.001).Conclusion. The frequency and patterns of upper respiratory tract manifestations depend both on the nosologic form of AAV and type of ANCA. Localized forms of URT involvement can be observed in patients with GPA and are closely associated with absence of ANCA, which determines the need for especially high suspicion level.
Segmented analysis of official statistical indicators dynamic series for osteoarthritis in 1994–2018 in Russia, the North-Western Federal district and the Arkhangelsk region
Authors: Makarova M. V. , Valkov M. Yu.
Published: October 2021

To improve the rheumatology service in the Russian Federation, it is necessary to determine the true extent of primary and general incidence of osteoarthritis (OA).The aim of the study is a detailed assessment of trends in the dynamics of OA incidence in the Russian Federation, the North-Western Federal district (NWFD) and the Arkhangelsk region (AR).Materials and methods. We evaluated trends in the dynamics of both incidence and prevalence of OA in the Russian Federation (RF), NWFD and AR in the period 1994–2018 based on data from the annual statistical reports of the Ministry of health of the Russian Federation (form 12). Data on the population of AR were obtained in the regional Bureau of statistics – Archangelskstat, for the northwestern Federal district and the Russian Federation from freely available statistical collections of Rosstat. We analyzed the indicators of the adult population (over 18 years old). To evaluate time trends, we used segmented analysis using the Joinpoint Regression Program (National Cancer Institute, USA) to analyze linear trends, evaluate their statistical significance, and identify time points of their change (joinpoints).Results. In the period from 2004 to 2012 in Russia was a decline in the number of annually detected cases of OA, the prevalence of OA increased steadily in the 2016 year recorded a decline in the number of cases of OA in NWFD and AR. The analysis showed a discrepancy in the trends of incidence of OA in the Russian Federation, the northwestern Federal district and AR, which was nonlinear and chaotic. In all territories, the prevalence was increasing. In the Russian Federation, the period from 2004 to 2008, when the primary incidence of OA fell sharply, was marked by a stable increase in the prevalence from 2041.6 to 3383.3 per 100 thousand population.

Conclusion. Analysis of official statistical information on the both incidence and prevalence of OA shows a significant variation in indicators, their fluctuations are not related to changes in the practice of diagnosis and treatment of this disease and, most likely, are associated with gaps in its accounting. Improving the epidemiological assessment of OA is possible with the introduction of a system of personalized patient registration-the osteoarthritis registry.
Type 2 diabetes mellitus and gout
Authors: Zhelyabina O. V. , Eliseev M. S.
Published: October 2021

Gout is the most common inflammatory arthritis in adults and has continued to increase in prevalence over the past decades. Gout is characterized by hyperuricemia with the obligatory crystallization of urates and an associated inflammatory reaction, as well as metabolic effects caused, among other things, by these processes. In particular, the diagnosis of gout is identified with a high risk of carbohydrate metabolism disorders, which is 2 times higher than the population risk: according to various sources, from 21 to 26% of patients with gout have type 2 diabetes mellitus (DM 2). However, the role of uric acid and urate-lowering drugs in its development in patients with gout remains controversial. The possibility of influencing the risk of developing diabetes mellitus type 2 of chronic inflammation, the activity of interleukin-1β and other pro-inflammatory cytokines, hyperuricemia, xanthioxidase and other factors associated with gout is discussed. It is possible that the level of uric acid is associated with diabetes and other metabolic diseases, causing pathophysiological changes not only through inflammation, but also oxidative stress, damage to the vascular endothelium. It is also suggested that gout and DM 2 may share genetic markers. The interrelation of violations of purine and carbohydrate metabolism prompts the search for drugs that have a simultaneous positive effect on purine and carbohydrate metabolism. However, it is not clear what the level of uric acid should be considered as a risk factor, there are conflicting data on the possibility of reducing the risk of developing diabetes with various anti-gout therapies.
Microscopic polyangiitis: Modern concepts and treatment options
Authors: Murkamilov I. T. , Aitbaev K. A. , Fomin V. V. , Kudaibergenova I. O. , Yusupov F. A. , Murkamilova Zh. A. , Beketova T. V.
Published: October 2021

The article summarizes the modern concepts of microscopic polyangiitis (MPA), a primary ANCA-associated systemic necrotizing vasculitis without immune globulin deposition (pauci-immune) that affects mainly small vessels, while granulomatous inflammation is absent. Necrotizing glomerulonephritis is very common and pulmonary capillaritis often occurs. MPA can cause rapidly progressive damage to organ systems. The modern possibilities of MPA treatment, primarily anti-B cell therapy with rituximab, are discussed.
Combination of rheumatoid arthritis and sarcoidosis, which had occurred during rituximab therapy, complicated secondary immunodeficiency and intolerance to the main basic drugs: Case repost and literature review
Authors: Golovina O. A. , Demidova N. V. , Alekseeva A. V.
Published: October 2021

Sarcoidosis is a rare multisystem disease which may accompany various autoimmune diseases in 17,6% cases. Despite of the fact that T-cell immunity impairments play a key role in these two conditions, their combination is extremely rare. It is difficult to choose therapy for patients with coexisted diseases, and it is even harder in case of comorbid pathology. In this article we considered a complicated case of treatment patient with a coexistence of rheumatoid arthritis and sarcoidosis, which had occurred during rituximab therapy. In addition to the combination of two autoimmune diseases, the selection of therapy for this patient was complicated by secondary immunodeficiency and intolerance to the main basic drugs.
Determinant of The Bitcoin Prices as Alternative Invesment in Indonesia
Authors: Andrean Gery
Published: November 2021

The aims of this study to know the determinant that affect bitcoin prices and how bitcoin prices response to the shock from GDP (Gross Domestic Product), inflation, exchange rate, JCI (Jakarta Composite Index. The method that was used in this research was quantitative analysis, with data analysis tools Vector Error Correction Model (VECM). Data used in this research was secondary data taken from Bank Indonesia, Bitcoincharts, and Yahoo Finance. The results of this study showed that (1) inflation in short term and in long term has negative significant effect on bitcoin prices, exchange rate in long term has positive significant effect on bitcoin price. In short term and in the long term GDP and JCI do not have significant effect on bitcoin prices (2) The results of IRF shows bitcoin prices respond negatively shock from GDP and exchange rate, while shock from inflation and JCI responded posifively by bitcoin prices.
Village Funds Utilization Strategy to Improve Food Security in Kuwu Village, Dempet Sub-District, Demak Regency
Authors: Yuliana Intan
Published: November 2021

The aim of this study was to analyze food security improvement strategy in line with the potency and problems, so that the utilization of village funds is more optimal and on target in order to support the financing of food security in Kuwu village, Dempet Sub-district, Demak Regency. The type of this research is quantitative research by using SWOT analysis. This research used primary and secondary data. The results of analysis showed that the utilization of Kuwu Village Fund was more concerned with physical development as well as transportation facilities and infrastructure. The results of SWOT analysis showed that the appropriate strategy to improve food security through the use of Village Funds in Kuwu Village is to support aggressive growth policy by maximizing the strengths and opportunities such as increasing food production capacity by intensification and diversification, human resource development, and improving the road infrastructure of farmer business.
Analisis Efisiensi Teknis Usaha Tani Sayur Organik (Studi Kasus di Kecamatan Getasan)
Authors: Sumastuti Efriyani , Sutanto Himawan Arif
Published: November 2021

Tujuan penelitian adaah untuk menganalisis tingkat efisiensi teknik usahatani sayuran organik di Kecamatan Getasan Kabupaten Semarang. Sebanyak 56 pelaku usahatani sayuran organik diambil sebagai sampel dengan purposive sampling. Stochastic frontier production function telah digunakan untuk menganalisis data dengan bantuan software frontier 4.1. Hasil penelitian ini menunjukkan bahwa tingkat Efisiensi produksi usahatani sayuran organik di Kecamatan Getasan Kabupaten Semarang belum efisien. Tingkat efisiensi teknis sebesar 0,98 sehingga masih ada peluang untuk mningkatkan efisiensi produksi sayuran organik di daerah penelitian. Benih, pupuk organik dan pestisida organik berpengaruh positif dan signifikan terhadap produksi sayuran organik. Luas lahan dan jumlah tenaga kerja tidak berpengaruh signifikan terhadap produksi sayuran organik. Hal ini menunjukkan sebagian lahan yang digunakan petani mengalami penurunan produktivitas. Disamping itu, sebagian petani menggunakan tenaga kerja keluarga dalam jumlah yang berlebihan. Untuk meningkatkan efisiensi dan produksi sayuran organik di daerah penelitian perlu adanya usaha peningkatan kesuburan lahan dan pembatasan penggunaan input, khususnya tenaga kerja keluarga.
Analisis Hubungan Pariwisata dan Pertumbuhan Ekonomi terhadap Emisi CO2 di Indonesia
Authors: Putri Mela Dipa Sekar , Oktayanti Rida , Amalia Suci , Amalia Hilda
Published: November 2021

The purpose of this study is to empirically examine how the relationship of tourism's influence and

economic growth on CO2 emissions. In this case the data used by researchers is the researchers took

some data on the number of foreign tourists coming to Indonesia and the economic growth that exists in

Indonesia to CO2 emissions in Indonesia. This study also examines the Environmental Kuznets Curve

(EKC) hypothesis between tourism income and CO2 emissions. To achieve this goal, researchers used

econometric regression techniques. The method used is using the OLS (Ordinary Least Square) method

and data using annual data (time series). In the results obtained get 2 results namely the level of economic

growth (x1) has a positive and significant effect on the level of CO2 emissions in Indonesia and the number

of foreign tourism (X2) has a positive and significant effect on the level of CO2 emissions in Indonesia.
QUALITY DEVELOPMENT MANAGEMENT IN IMPROVING THE COMPETITIVE ADVANTAGE OF PRIVATE VOCATIONAL SCHOOLS IN JAMBI PROVINCE
Authors: Triani Lidya , Hasibuan Lias , Imron Rosyadi Kemas
Published: October 2021

This study aims to find a profile of Quality Management Implementation in three Private Vocational High Schools with a detailed aim of finding an implementation model to provide information to all other private vocational high schools that have not achieved “A” accreditation so that they can achieve “ A “ accreditation. This research is a qualitative research, where the reseach is conducted in three private vocational high schools in Jambi city which are accredited “A” represented in Yadika, PGRI 2, Pelita Raya schools. Data collection techniques using observation, interview and documentation, data Analysis using the Cresweel model and data valiidity techniques using data triangulation. The results of the research on Implementation of Quality Development Management at private vocational high schools in the form of innovative ideas that are applied in the field, cover a number of aspects that are quite broad because the customers of a Bujan scholl are only students but also administrative staff, teachers, and stakeholders or the community. The Conclusion of this study is that the Quality development management in Increasing the Competitive Advantage of Private vocational high schools in Jambi Provinces is the existence of a solid and responsible team commitment and cooperation in order to get special attention from the community and become an option for the community, the success factor of the Implementation of Quality development management, what can increase competitive advantage in private vocational schools in Jambi Province is organized management, supported by reliable human resources, good relations with the enviroment and the world of work, mature leadership policies, support from foundations and a solid work plan.
EDUCATION SUPERVISION IN THE CREDIBILITY COMPETENCY OF PROFESSIONAL TEACHER
Authors: Arif Syamsul
Published: October 2021

Every activity of the school organization must be supervised by the principal. This is important because without supervision, all school program activities will not be successful. In this case, if there are deviations, it cannot be detected early and in detail. The role of the principal in this case is very important, in other words that success in carrying out supervision is largely determined by the skills of the supervisor. Supervision comes from the words super and vision which means to see and review from above or view and judge from above what is done by superiors on activities, creativity, and bottom performance.
Value Addition, Packaging and Storage of Aonla in India
Authors: SHUKLA ADITYA , Ramchandra Ramchandra
Published: October 2021

The product Aonla (Emblica officinalis Geartn), the king of arid fruits, popularly known as “Indian gooseberry”, is a small-sized minor subtropical fruit grown widely in North India. India ranks first in the world in aonla area and production volume. It is considered to be a “wonder fruit for health” because of its unique properties. Uses. Aonla fruit is very useful in treating many diseases such as diabetes, cough, asthma, bronchitis, headache, dyspepsia, colic, flatulence, skin diseases, leprosy, jaundice, scurvy, diarrhoea and cancer. Packaging. Different packaging materials such as nylon net, perforated polyethylene bags, ventilated corrugated fibre boxes, gunny bags, wooden crates, etc., can be used for prolonging the storage life of fruit. Storage. Refrigerated storage helps in enhancing the storage life of fruit. Value addition. There are numerous products such as aonla squash, candy, jam, chutney, etc., which are pre- pared from aonla fruit. Inclusion of these products in the diet definitely helps in improving the nutritional value of Indian meals. Discussion. The low cost of the products as well as good sensory, nutritional and shelf life qualities mean that processed aonla products are appropriate for commercialization. In order to obtain a good income from aonla, it must be sold immediately in the market; if not, to make profit, proper storage facilities should be available.
Macro-level study on Climate Change effects on agriculture and human health in Western Himalayas: A Review
Authors: Mohanty Ashutosh
Published: October 2021

The current study reveals that the western Himalayas has a fragile ecosystem, highly susceptible to rapid changes in land morphology due to the consequences of climate change. Land-use and climatic change in this region has negative impacts on agriculture and human health. Increasing temperature, erratic precipitation, and rising CO2 concentrations are the main drivers which show adverse effects on agriculture and human health. The impacts trends in this region can be categorised into exacerbated pathogenicity are pathogens, and hence disease outbreaks, changes in the traditional agriculture techniques, and people’s migration that directly changes in ecological and leading to social inequalities. In the last few decades, there have been changes in vector species distribution in agriculture and increases of forest pest species attacks by climate change in agriculture and forest pest increases, and parasites are emerging during periods of these last few decades. Enhancement of seasonal transmission and distribution of pests pushes food insecurity and vector-borne infections deteriorate human health. This review article tries to analyse different literature on the effects of climate change on agriculture and human health in the Western Himalayas and suggest agroforestry and agroecology is some of the strategies to overcome climate change impact.
Development of Soil Moisture Index for Planning Water Management in the State of Sikkim (India)
Authors: Kusre B C , Bora P K , Rai Deependra
Published: October 2021

Soil moisture and soil temperature are two important parameters that have a wider implication on crop production. The drop of soil moisture and temperature has an impact involving climate, vegetation and drought. The presence of soil moisture does not ensure its availability to a crop but the force by which water is held by soil particle is important. The amount of work done to extract soil moisture is generally expressed as stress. It is necessary to understand the extent of stress for proper water resources management. The soil moisture index (SMI) is a criterion that denotes the extent of stress experienced by a crop. The temperature also has an impact on germination and production. In the present study, we developed a SMI for different locations in Sikkim. The index ranges from +5 to -5. The negative index indicates extreme stress. The study indicated during winter the index goes beyond-3. Considering wilting point stress as 500 and 700 kPa. The soil temperature was also observed to fall below 15 C. Further, it was observed that soil temperature and moisture are strongly correlated to each other. The SMI can play an important role in adopting suitable water management practices for improved crop production.
Common GP queries in infancy and childhood
Authors: Ireland Sue , Placzek Monica
Published: November 2021

CARDIAC MURMUR, COLIC, CROUP, HAEMANGIOMA, HEARING, HIPS, HYDROCELE, INGUINAL HERNIA, JAUNDICE, LABIAL ADHESIONS, MMRVACCINE, 

SACROCOCCYGEAL PIT, UNDESCENDED TESTICLE, TONGUE TIE, UMBILICAL GRANULOMA, UMBILICAL HERNIA.