bluuebunny/crossref_metadata_2025 huggingface dataset:
PBS lessen; de didactische benadering van gewenst gedrag
Authors: Wichers-Bots José , Boezen Wil , Harleman Harry , Hazenberg Dorothee , Luttje Sander , Ulenaers Yolande
Published: May 2024

In dit deel ‘PBS-lessen; de didactische benadering van gewenst gedrag’ wordt beschreven hoe op het Kandinsky College PBS-lessen zijn ontwikkeld en gegeven, lessen waarin verwacht gedrag wordt aangeleerd. Voorbeelden van ontwikkelde lessen zijn opgenomen. In het eerste hoofdstuk stellen we ons aan u voor, vertellen we kort onze PBS-historie en wat PBS onze school gebracht heeft. In het tweede hoofdstuk kunt u lezen waar, op basis van een theoretische onderbouwing, een goede PBS-les aan moet voldoen. In hoofdstuk drie gaan we in op onze beleidskeuzes, interventies en data ten behoeve van een schone aula. Waarom hebben we gekozen voor een aanpak van onze aula? Hoe zijn we te werk gegaan en wat betekent dit bijvoorbeeld voor onze pauzesurveillance? In hoofdstuk vier wordt beschreven hoe we de stap naar de bovenbouw hebben gemaakt, en hoe we op basis van data gekozen hebben voor de gedragsverwachting ‘Be ready’: klaar zijn voor de les. De data waarop besluiten zijn genomen, de ontwikkelde materialen en de filmpjes die wij in dit deel noemen zijn terug te vinden op de website www.swpbs.info In de dagelijkse praktijk op school spreken we niet over SWPBS, maar over PBS en dus ook in dit deel.
Unilateral Ocular Toxoplasmosis Revealed by Total White Cataract: A Case Report
Authors: Krichene M. A. , Hazil Z. , Hassina S. , Tebbay N. , Hasnaoui I. , Akannour Y. , Serghini L. , Abdellah E.
Published: May 2024

Ocular toxoplasmosis is a significant and often underestimated ophthalmological condition that can lead to severe visual impairment in immunocompetent individuals. This infection, caused by the protozoan Toxoplasma gondii, is the main cause of infectious posterior uveitis in this population. Although the typical form of the disease is focal posterior uveitis, a variety of clinical presentations can occur, complicating diagnosis and management. Here, we report a rare case of unilateral ocular toxoplasmosis revealed by a total white cataract in an immunocompetent patient, highlighting the diagnostic and therapeutic challenges clinicians may face.
Document Similarity Analysis and Template Matching in Health Insurance Using Python Flask
Authors: Revathy S. P. , Srimathi R. , Yuvapriya H.
Published: May 2024

In recent days, a primary challenge faced by healthcare insurance organizations is the reliance on a large number of files to process insurance claims and make coverage decisions. With the gradual increase in medical insurance in India, the number of people buying medical insurance plans is rising. Document processing plays a pivotal role in the efficient management of health insurance policies and claims. This proposed study presents an innovative approach to document template matching specifically tailored for the health insurance domain, implemented using the Python Flask web framework. Integration with Python Flask offers scalability, flexibility, and ease of deployment, making it suitable for a wide range of insurance applications. This solution represents a significant advancement in document processing technology, empowering health insurance professionals with a comprehensive tool to effectively manage and analyze documents.
An Ensemble Machine Learning Technique for Bitcoin Price Prediction
Authors: Saraswathi S. , J S Sridhala , Elavazhagan A. , Sabharwal Jasbir Singh , Mohammad Sajid Ibni
Published: May 2024

This research proposes an ensemble approach for Bitcoin price prediction, leveraging historical price data and sentiment analysis. The proposed ensemble approach combines the model with Gated Recurrent Unit (GRU) and Bidirectional Long Short-Term Memory (BiLSTM) to further improve the accuracy in prediction by considering dynamics in the market. The model also addresses the problem of generalization and overfitting, adaption to the changing, dynamic nature of the market. Historical price data and sentiment scores from the preprocessing of the text are combined to the ensemble framework. These data are then fed into GRU and BiLSTM models for training, as the data contain not only complex temporal patterns but also sentiment-driven trends. The ensemble strategy could be beneficial for the strengths of the models and for improving the performances of the predictors. Most importantly, features are engineered in terms of technical indicators, lagged variables, and external factors impacting the price of Bitcoin. Sentiment analysis with the news and on social media complements insight into market sentiment, which adds value to the prediction power of the model.
DOENÇAS ESTRUTURAIS DO SISTEMA CARDIOVASCULAR E SUAS INTERVENÇÕES
Authors: Cheyenne Maria Rodrigues Verçosa Amaral
Published: May 2024

O sistema cardiovascular, composto pelo coração, vasos sanguíneos e sangue, é a base da vida humana. Quando essa estrutura complexa apresenta alterações em sua anatomia ou funcionamento, surgem as doenças cardiovasculares (DCVs), que representam a principal causa de morte no mundo.O objetivo deste estudo foi descobrir fatores de risco como ansiedade, depressão, características de personalidade e qualidade do sono, bem como sua probabilidade de afetar a fonte da hipertensão arterial, alternativas de controle, tratamentos, exposição e adoecimento, e como eles alteram a dinâmica de risco e controle de saúde. O estudo mostrou que a resposta cardiovascular de um paciente com hipertensão em situações de tensão interpessoal depende do grau de estresse e das características de sua personalidade. Ansiedade, depressão, características de personalidade e qualidade do sono estão entre os fatores de risco para hipertensão arterial. Pesquisas mostram que o treino de controle de estresse (TCS) e a terapia cognitivo- comportamental são bons tratamentos para depressão e ansiedade, além de reduzir a reatividade.
HISTOLOGICAL FEATURES OF THE ELK’S DIGESTIVE TRACT ORGANS
Authors: Mechnikova Irina , Donkova Natalya
Published: May 2024

The purpose of research is to study the histological features of some organs of the digestive tract of elk. The work was carried out in 2023 at the Department of Anatomy, Pathological Anatomy and Surgery of the Krasnoyarsk State Agrarian University. The organs of the elk's digestive tract were subjected to histological examination: the esophagus, rumen, reticulum, booklet, abomasum and duodenum. Sections 5–7 μm thick were stained with hematoxylin and eosin using the Mallory method, Congo red, and viewed under a light microscope. It was revealed that the wall of the digestive tract of the elk as a whole has a histological structure typical of ruminants and is built from layers: mucous membrane with submucosa, muscular and outer membrane, represented by adventitia (in the esophagus) or serous (in other parts of the digestive tract). The mucous membrane is lined with epithelium, which changes along the course of the digestive tube from multi-layered (esophagus, rumen, reticulum, booklet) to single-layered (abomasum, intestine). The multilayered epithelium of the mucous membrane in the esophagus has signs of keratinization, and in the rumen, reticulum and booklet, keratinization is expressed only at the tops of the papillae. The smooth muscle plate is detected in the folds of the mucous membrane of the esophagus, rumen, abomasum, as well as in the leaflets of the booklet and the ridges of the reticulum, but it is absent in the papillae of the rumen, the papillae of the leaflets of the booklet and the papillae of the ridges of the reticulum. Distinctive features of the elk digestive tract are the presence of lipocytes in the muscular plate of the mucous membrane and in the submucosa of the abomasum, where adipose tissue almost completely replaces loose connective tissue. In addition, the muscular lining of the esophagus, along its entire length, is built exclusively from striated muscle tissue.
ANALISIS PENGARUH SISTEM TERMIN PROYEK TERHADAP PROFITABILITAS KONTRAKTOR
Authors: Mirayani Pradnyadari Ni Luh Made Ayu , Ngurah Sunatha I Gede , Emi Udayani Ni Made
Published: May 2024

Pengembangan proyek konstruksi merupakan sektor yang memiliki signifikansi besar dalam mendukung ekonomi suatu negara. Bagi para pelaku bisnis di industri konstruksi, mencapai tingkat profitabilitas yang maksimal menjadi hal yang sangat penting. Namun, terkadang dalam proyek-proyek pemerintah, kontraktor harus menyetujui perjanjian kerja yang telah disusun oleh lembaga pemerintah. Perjanjian tersebut mencakup rincian pembayaran, seperti pembayaran bulanan, termin, atau pembayaran akhir. Penelitian ini dilakukan pada proyek Pembangunan Gedung Lantai II SD N 2 Dangin Puri Denpasar, dengan menggunakan data Rencana Anggaran Biaya (RAB) dan Time Schedule yang diperoleh dari CV. Manggala, kontraktor yang terlibat. Penelitian ini mengkaji empat variasi uang muka dan empat variasi termin, yaitu dengan uang muka sebesar 0%, 10%, 20%, dan 30% serta termin I (30%,20%,25%, dan 25%), II (20%,25%,25%dan 30%), III (25%,30%,25%, dan 20%),dan IV (30%,40%,20%,dan 10%). Variasi ini kemudian dianalisis menjadi 16 alternatif. Hasil analisis menunjukkan bahwa vaiasi pembayaran dengan saldo kas akhir terbesar adalah alternatif XV (uang muka 30%, termin 25%, 30%, 25%, 20%) sejumlah Rp530.157, dengan pinjaman bank sebesar Rp400.000.000. Di sisi lain, variasi pembayaran dengan saldo kas akhir terendah adalah alternatif IV, dengan saldo kas akhir sebesar -Rp42.449.817 dan pinjaman sebesar Rp2.500.000.000. Profitabilitas tertinggi bagi kontraktor ditemukan pada variasi pembayaran alternatif XV (uang muka 30%, termin 25%, 30%, 25%, 20%) sebesar 0,01% dari nilai kontrak. Sementara itu, profitabilitas terendah tercatat pada variasi pembayaran alternatif IV (uang muka 0%, termin 30%, 40%, 20%, 10%) dengan angka -0,67%.
Infidelidad en estudiantes universitarias: estilos de comunicación en pareja y conducta sexual
Authors: Peña Peña Anibal Uriel , Mendoza González Brenda
Published: May 2024

El objetivo del estudio fue analizar la clasificación de estudiantes universitarias en función de su comportamiento infiel utilizando las categorías: estilos de comunicación en pareja y conducta sexual. Participaron 454 mujeres universitarias de 18 a 28 años (x̄ = 20.28; σ = 1.785). Se utilizaron instrumentos válidos y confiables. Se realizó un análisis multivariado con la variable infidelidad, identificándose tres grupos: “Deseo de vínculo romántico”, “Infieles” y “No infieles”. Se empleó un ANOVA para contrastar a los tres grupos, encontrándose diferencias de acuerdo con las variables comunicación de pareja y conducta sexual. Se concluye que el grupo “No infieles” es más receptivo socialmente y se comunica positiva y amablemente con sus parejas, demostrando menos conductas seductoras; el grupo “Deseo de vínculo romántico” muestra un estilo de comunicación negativo con sus parejas, y mayor conducta sexual; y el grupo “Infieles” manifiesta más conductas de seducción que los otros dos grupos.
Eudaimonia as a treatment goal in psychotherapy and psychosomatic medicine
Authors: Linden Michael
Published: May 2024

Psychotherapy encompasses a broad range of goals, ranging from the alleviation of symptoms and the prevention of recurrence to the enhancement of well-being. These goals are mostly cross-sectional and hedonic-oriented in the sense of wellness, happiness, and absence of pain. However, an alternative goal is eudaimonia, which involves mastery of life from a long-term perspective. This pursuit entails embracing and even seeking hardship and confrontation with adversities for the sake of higher goods and goals. Eudaimonia, both an attitude and a behavior, is essential for everybody, especially individuals facing challenging circumstances and burdensome life situations, such as familial burdens, job problems, and illness. Eudaimonia can be attained through wisdom, which is regarded in lifespan psychology as a multidimensional capacity for coping with complex challenges and dilemmas in life. Initial studies suggest that wisdom skills are trainable, opening additional avenues in psychotherapy and psychosomatic medicine. It is argued that eudaimonia deserves increased attention in psychotherapy and psychosomatic medicine.
PENINGKATAN KETERAMPILAN MENGOLAH PANGAN LOKAL MELALUI KEGIATAN BINA GIZI DI WILAYAH LOKUS STUNTING DESA SUKAJADI KECAMATAN CISAYONG KABUPATEN TASIKMALAYA
Authors: Sumarto  , Nuraeni Irma , Karimah Ima , Setiawati Dina , Hadiningsih Naning
Published: May 2024

Permasalahan stunting di wilayah lokus stunting di Desa Sukajadi, Kecamatan Cisayong, Kabupaten Tasikmalaya masih tinggi. Salah satu faktor langsung penyebab stunting pada balita adalah asupan gizi dan faktor tidak langsung adalah penghasilan atau ekonomi keluarga. Sehingga perlu upaya terpadu dengan salah satunya melalui pendidikan gizi untuk meningkatkan pengetahuan dan keterampilan para kader calon pengusaha dalam mengolah pangan lokal yang ada di sekitarnya. Tujuan kegiatan ini adalah untuk meningkatkan pengetahuan dan keterampilan sasaran dalam mengolah pangan lokal berbasis sayuran. Metode intervensi adalah dengan pendidikan gizi melalui ceramah dan demonstrasi. Perubahan pengetahuan diukur melalui pre-test dan post-test. Variabel keterampilan diukur melalui observasi.  Hasil pengabdian kepada masyarakat menunjukkan bahwa pengetahuan peserta tidak berubah dengan nilai yang baik yaitu 90. Peserta meningkatkan keterampilannya dalam mengolah sistik dari bahan baku sayur yaitu wortel, ubi ungu, dan bayam. Perlu dilakukan kegiatan lebih lanjut dalam pengembangan usaha melalui pendampingan perolehan izin edar dan survei pasar.
MORPHEMIC ANALYSIS AS AN EDUCATIONAL PARADOX
Authors:   Baikal State University, Kravchenko Alexander
Published: May 2024

The theoretically untenable and empirically inadequate code model of linguistic communication predetermines the paradoxical situation in education, when the Russian language, as a school subject, becomes one of the hardest in the school curriculum, while the didactic goal it aims to achieve is vague and indeterminate. The hypostatization of linguistic signs into autonomous container-like objects with meanings as their contents motivates the so-called morphemic analysis - the breaking down of words into their components (morphemes) that possess specific «quanta» of meaning, while the educational purpose of such an “analysis” is unclear, and its cognitive value is negligible, because morphemic analysis does not relate to the practice of living in language.
EMOTIVE ANALYSIS OF THE TEXT (BASED ON THE STORY OF CH. AYTMATOV “TO HAVE AND TO LOSE”)
Authors:   Kyrgyz National University named after Jusup Balasagyn, Shermatova Saadat Nurlanovna
Published: May 2024

The article defines the various functions of the use of emotive vocabulary in the story “To Have and to Lose” by Ch. T. Aitmatov. As the analysis showed, the story is dominated by positive emotions, the most touching feelings associated with love, care, and respect.
THE DEVELOPMENT OF DIGITAL COMPETENCE OF STUDENTS WITH THE USE OF THE RESOURCES OF THE TECHNOLOGY PARK OF UNIVERSAL PEDAGOGICAL COMPETENCIES
Authors:   Altai State Pedagogical University, Kustova Svetlana Victorovna
Published: May 2024

The article deals with the issues of training foreign language teachers to be able to teach foreign languages in the conditions of digitalization of modern education. It is concluded that it is necessary to develop digital competence in future foreign language teachers, that is, the ability to use digital technologies in education, skills in presenting information in different digital formats, in educational video films in particular. On the basis of the research and experience of training future teachers of foreign languages the author introduces the conditions for the development of digital competence of future foreign language teachers with the use of the resources of the technology park, and devises the methods for developing students’ digital competence while working on an educational product - a video film for schoolchildren.
METAPHOR AS AN ATTEMPT TO “LOOK INTO” THE ESSENCE OF THINGS
Authors:   Catholic University of Daegu, Zhgun Daria Aleksandrovna
Published: May 2024

The paper represents deep comprehension of metaphor taking into account the interdisciplinary nature of modern linguistic research, particularly the integration of knowledge from philosophy and psychology into it. The need for an integral approach to the study of the phenomenon of metaphor is determined by the shift of the focus of attention observed in recent decades to the trope towards logic and a deterministic understanding of the essence of consciousness overall, oftentimes leading to contradictions in theories of metaphor and numerous disputes about its nature. On this ground, the author of the article proposes to study metaphor both from the viewpoint of cognitive theories and within the framework of a holistic paradigm, in which the world is interpreted as a system, and the individual is able to perceive things in their interconnection and unity, thereby revealing more profound layers of meaning. During the analysis of the theory and examples from literature, the author comes to conclusion that metaphor is something more than the work of the brain, namely, it is an attempt to see the essence “through the mind.”
The Influence of Interactive Web Platforms on the Development of Future Specialists’ Communication Competences
Authors: Karlova Nadiia , Kotienieva Iryna , Kotienieva Juliia , Sievastianova Olena , Pavlenko Iryna
Published: May 2024

The article aims to find out the specific features of the use of interactive web platforms for developing components of communicative competence of future specialists in various fields. The study used testing, observation, and experimental procedures. The sample was from students majoring in Secondary Education, Philology, and Journalism. The study confirmed the hypothesis about the effectiveness of using web platforms to develop future specialists' communicative competence. The average indicators of communicative competence's cognitive and activity components prevail in the studied future specialists. At the same time, communication skills are not sufficiently developed. Significant positive changes have been recorded in the cognitive and activity components of communicative competence. The motivational component remained unchanged due to the formative impact – a decrease in the fear of rejection was found only in the group of future teachers. In general, the developed online program does not significantly depend on the specialty, as the developed exercises have already considered the specifics of a particular area of training. The obtained results can be used to optimize forming communicative competence in higher education. Thus, the conclusions about using web platforms to develop communicative knowledge and skills of future specialists are practically valuable. Further research could address prospects in expanding the range of specialties studied and clarifying the data obtained by comparing them with the results of the control groups.
Corundum in Sulfide Ore at the Thompson Mine, Manitoba, Canada: An Unusual Occurrence of Cr- and Ni-Bearing Corundum
Authors: Belley Philippe M. , Onodenalore Ofure C. , Bleeker Wouter
Published: May 2024

A novel type of corundum host environment is described from the Thompson Mine, northern Manitoba, where corundum occurs within a high-grade metamorphic reaction zone between boudinaged metaperidotite bodies, sulfide ore, and Al-rich pelitic schist of the Pipe Formation (Ospwagan Group). Zoned corundum porphyroblasts, up to 20 mm across, contain coevally formed sulfide inclusions, zircon, rutile, abundant exsolved rutile needles, and secondary sulfide inclusions formed within fractures. Retrograde alteration products of corundum include greenish muscovite (in contact with the schist) and diaspore (in contact with sulfides). The median concentrations of trace elements in Thompson corundum are as follows (in µg/g): 119 Mg, 1720 Ti, 69.9 V, 390 Cr, 8.2 Mn, 1924 Fe, 9.1 Ni, and 106 Ga. The geochemical signature of Thompson corundum (enrichment in Fe, Cr, and Ni) resembles that of ruby in other metamorphic and metasomatic mafic-ultramafic-hosted deposits, and the Cr concentration is comparable to the low range of rubies. Thompson corundum contains high Ni concentrations relative to most Cr-enriched corundum occurrences, a result of formation in an exceptionally Ni-rich environment. The high abundance of exsolved rutile inclusions imparts a dominantly brownish-gray color to the corundum, which precludes it from being of gem quality. Chromium-bearing corundum has been suggested as a possible indicator mineral for metamorphosed massive sulfide deposits, however, it is an indirect indicator that risks yielding false positives. Further investigation into Ni concentrations in corundum, a potential indicator of formation in a Ni-rich environment, is recommended.
Türk Gazetelerindeki “Televizyon” ve “Televizyon Yayıncılığı” Temalı Haberlerin Analizi (1929-1952)
Authors: Çakır Ali
Published: May 2024

Bu çalışmada, Türk gazetelerinin 1929-1952 yılları arasındaki nüshaları “televizyon” ve “televizyon yayıncılığı” temaları üzerinden taranmıştır. Çalışmanın sınırı olarak Türkiye’nin kuruluşu ile Türkiye’de ilk televizyon yayını denemesi arası seçilmiştir. Verilerin toplanmasında, internet ortamında bulunan gazete arşivlerinden yararlanılmıştır. Veriler, doküman inceleme ve tarihi araştırma yöntemleri kullanılarak analiz edilmiştir. Araştırmada kullanılan gazeteler ve gazetelerdeki haber sayıları, tablo yapılarak değerlendirilmiştir. Elde edilen veriler doğrultusunda, Türkiye’deki televizyon yayıncılığının ilk dönemi incelenmiştir. Yapılan incelemede dört alt başlık belirlenmiştir. Bunlar sırasıyla: “Televizyonun Keşfini Konu Edinen Haberler: Tarihçe, İlk Gelişmeler ve Televizyonun Farklı Alanlarda Kullanılması”, “Televizyon Yayınlarını Konu Edinen Haberler”, “Televizyonun Yaygınlaşmasını Konu Edinen Haberler: Halkın Televizyon Edinimi ve Televizyon-Sinema İlişkisi” ve “Türkiye’de Televizyonun Gelişimini Konu Edinen Haberler: İlk Denemeler, Uygulamalar, Yurt Dışı Gelişmeleri ve Tahayyüller” şeklindedir. Türkiye’nin ilk yıllarında yapmış olduğu modernleşme hamlelerinin kapsadığı alanlardan biri de yayıncılık olup bunun televizyon yayıncılığı özelinde kitle iletişim araçlarına ne şekilde yansıdığı, çalışmanın ana problemini oluşturmaktadır. İlaveten dünyadaki gelişmelerin takip edilip edilmediği ve anılan gelişmelere ne surette intibak edilmeye çalışıldığı diğer bir problem olarak belirlenmiştir. Çalışmanın sınırları dâhilinde televizyon yayıncılığı Türkiye’de başlamadığı için “yeni bir buluş”a karşı ilk tepkileri ölçmek amaçlanmıştır. Elde edilen verilerin analizi sonucunda, Türkiye’de televizyon yayıncılığı sürecinin Batılı devletlerden geç başladığı görülmüştür. Bununla birlikte dünyada yaşanan gelişmelerin takip edildiği de gazetelerden anlaşılmaktadır. II. Dünya Savaşı’nda sonra yayınlanan gazetelerde, televizyon yayıncılığıyla ilgili ajans haberlerinin yanında gazetelerin kendi haberlerini ürettikleri görülmüştür. Bu durumu, halkın konuya ilgisinin arttığı şeklinde görmek mümkündür. Ayrıca televizyon yayıncılığı sürecinin, II. Dünya Savaşı ile birlikte tüm dünyada kesintiye uğradığı görülmüştür.
Units of fibrinolytic system in mice with urokinase gene knockout in presence of growing B16/F10 melanoma
Authors: Frantsiyants E. M. , Bandovkina V. A. , Surikova E. I. , Kaplieva I. V. , Pogorelova Yu. A. , Neskubina I. V. , Trepitaki L. K. , Cheryarina N. D. , Ushakova N. D. , Ishonina O. G. , Gusareva M. A. , Udalenkova I. A.
Published: May 2024

Purpose of the study. Was to reveal the effect of urokinase gene knockout in male and female mice with transplanted  B16/F10 melanoma on the functions of the fibrinolytic system units.

Materials and methods. Male and female mice were used: main group with genetically modified mice C57BL/6-Plautm1. 1Bug – ThisPlauGFDhu/GFDhu (uPA-/-); control group with С57Bl/6 (uPA+/+) mice. B16/F10 melanoma was transplanted by the standard methods to the animals, and levels of plasminogen (PG), plasmin (PAP), urokinase receptor uPAR, content (AG) and activity (act) of uPA, t-P A and PAI-I were measured with ELISA (Cussabio, China) in 10 % tumor homogenates and peritumoral area after 3 weeks of tumor growth.

Results. The activity and levels of urokinase in intact uPA-/- animals were significantly (by 100–860 times) inhibited, compared to uPA+/+, but uPAR levels were unchanged in females and were 1.9 times lower in males. PAP levels in uPA-/- mice were 2.1–4.2 times higher than in uPA+/+ animals. The growth of B16/F10 melanoma in uPA-/- mice was slower and metastasizing was suppressed, but their survival was not improved. The dynamics of changes in components of the fibrinolytic system in presence of melanoma growth differed in uPA-/- mice, compared to uPA+/+ animals: PAP levels in tumor samples decreased by over 2 times, uPA levels and activity were not increased, PAI was practically unchanged, but activity of t-P A elevated by 3.8–8.2 times, as well as in uPA+/+ mice.

Conclusion. Despite the suppression of the growth and metastasis of the primary tumor nodes in uPA-/- mice, their average survival was not improved, which indicates that the mechanisms of tumor are complex and there are alternative biological pathways supporting melanoma to survive in conditions of the urokinase gene knockout.
Hypoxia effect on proliferative activity of cells in orthotopic xenograft of hepatocellular carcinoma of the liver in the experiment
Authors: Kecheryukova T. M. , Trifanov V. S. , Shulg A. A. , Goncharova A. S. , Gurova S. V. , Ulyanova E. P. , Maksimov A. Yu.
Published: May 2024

Purpose of the study. The purpose of this research was to investigate the effect of in vivo hypoxic conditions on the proliferative potential of HepG2 liver cancer cells.

Materials and methods. Human liver cancer cells of the HepG2 line have been cultured. The HepG2 cell suspension was injected subcutaneously into mice in an amount of 5 × 106 to obtain a xenograft. Tumor nodes that had reached the required size were divided into fragments and transplanted into the orthotopic site. Balb/c nude mice with implanted HepG2 liver cancer xenograft were used in this experiment. The mice with tumor implanted in the liver were divided into two groups, intact and hypoxic. Mice from the second group underwent liver blood flow reduction by occlusion of the portal triad for 20 minutes. Tumor nodes were extracted for histological and immunohistochemical staining for proliferation marker Ki-67 on the 4th day after the procedures. The proportion of positively stained cells was calculated, and the results were statistically analyzed using the Statistica 10.0 software.

Results. Orthotopic models of liver cancer in Balb/c Nude mice were obtained. Histological and immunohistochemical studies were carried out. Histological analysis showed that hepatocellular carcinoma is characterized by an average degree of differentiation. In the tissues of these xenografts, by using immunohistochemical analysis for the proliferation marker Ki-67, it was possible to identify statistically significant differences between the two groups, i.e. intact and the one with reduction of blood flow. The proportion of immunopositive cells was 65 [65–70] % and 19 [15–25] %, respectively.

Conclusion. A tendency to decreased proliferative activity of tumor cells after hepatic blood flow reduction, i.e. hypoxia exposure, was demonstrated. Our data indicate that the proliferative activity of tumor cells is directly related to the microenvironment, and to the hypoxic environment in particular. Further study of the effect of hypoxia on the processes of growth and development of malignant tumors may contribute to a deeper understanding of the biological features of tumors and their treatment.
Dynamics of saliva cytokine levels during intraoperative photodynamic therapy in patients with locally advanced oral cancer
Authors: Komarova E. Yu. , Zlatnik E. Yu. , Komarova E. F. , Novikova I. A. , Dzhenkova E. A. , Engibaryan M. A. , Sagakyants A. B. , Pozdnyakova V. V. , Rozenko L. Ya.
Published: May 2024

Purpose of the study. Assessment of the level of certain cytokines in the saliva of patients with primary locally advanced cancer of the oral mucosa in addition to surgical treatment with intraoperative PDT (IPDT).

Patients and methods. Patients with primary locally advanced cancer of the oral mucosa T3-4aN0-2M0 were divided into 2 groups: the main group (30 patients) underwent radical tumor removal supplemented with IPDT and the control group (30 patients) without addition. IPDT was performed using Latus-T (farah) and a chlorin E6 photosensitizer. Cytokine levels were determined in unstimulated whole saliva the day before, on the 3rd and on the 7th day after the operation by the ELISA multiplex analysis method.

Results. A similar dynamic of the cytokine profile of patients of both groups was shown: on the 3rd day after surgery, the levels of G-CSF, IL-6, MIP-1β increased, and GM-CSF and IFN-γ decreased compared with baseline values. On the 7th day, the dynamics of G-CSF, GM-CSF, IL-6 persisted, while IL-8, IL-10, IL-12 changed to the opposite.

Intergroup differences were revealed in the level of IL-1β - on day 3, an increase in the main group and a decrease in the control group. The level of IL-7 on day 7 decreased sharply in the control group and increased statistically significantly in patients receiving IPDT. The main group showed a 4.8-fold increase in IL-8 on day 3 and its 3.6-fold drop on day 7 with the opposite dynamics in the control group. The TNF-α level increased only in the main group on day 7, and in the control group it decreased by 3 and recovered on day 7. On day 3, the MCP-1 level increased in the main group and decreased in the control group. The level of IL-17 in the main group increased on the 3rd day with a further decrease below the baseline, and in the control group it decreased on the 3rd day, followed by a recovery on the 7th. An increase in IL-5 and IL-13 levels on day 3 was noted only in the control group, however, the level of IL-5 in both study periods in the main group was lower than in the control group.

Conclusion. IPDT in patients with primary locally advanced oral cancer causes changes in the cytokine composition of saliva during the first week after surgery, some of which can be associated with an elongation of the relapse-free period in such patients.
PENINGKATAN KOMPETENSI WISATA KEARIFAN LOKAL DALAM MENDUKUNG PENGEMBANGAN WILAYAH KELURAHAN TANJUNG PIAYU KECAMATAN SEI BEDUK
Authors: Andhika Pradita F  , Syafrijal  , Yuanita FD Sidabutar
Published: May 2024

This research was conducted with the aim of increasing the competence of local wisdom tourism and supporting regional development in Tanjung Piayu Village, Sei Beduk District. Participatory methods are used to involve local residents and tourism actors in decision making and program implementation. Community participation in tourism development is increasing and contributions to economic and environmental sustainability in the region are increasingly visible. The research results show that increasing community participation in tourism development can make a significant contribution to economic and environmental sustainability in the region. The SWOT analysis method used in this research helps involve local residents and tourism actors in decision making and program implementation more effectively. In the training programs and workshops held, it can be seen that the knowledge and skills of local residents in managing local wisdom tourism are increasing. Increasing the competence of local wisdom tourism can play an important role in regional development. Training and outreach programs have also proven effective in increasing community participation in tourism development.
PENGEMBANGAN POTENSI KEARIFAN LOKAL YANG MENDUKUNG PARIWISATA DI KAMPUNG TUA PATAM LESTARI KELURAHAN PATAM LESTARI KECAMATAN SEKUPANG KOTA BATAM
Authors: Fairuzzabadi  , Herman Suranta Ginting  , Yuanita FD Sidabutar  , Malahayati Rusli Bintang
Published: May 2024

Pariwisata merupakan salah satu sektor pembangunan di bidang ekonomi. Sektor pariwisata di Indonesia saat ini diandalkan sebagai sektor alternatif yang diharapkan dapat memberikan kontribusi terhadap pertumbuhan perekonomian Negara. Pengembangan sektor pariwisata menjadi salah satu program unggulan dalam usaha pembangunan daerah yang juga diharapkan dapat memberikan konstribusi terhadap penerimaan Pendapatan Asli Daerah (PAD) dan menciptakan lapangan kerja di daerah. Pengembangan pariwisata di daerah juga dapat dilakukan dengan mengembangkan potensi-potensi kearifan lokal yang terdapat di daerah tersebut. Potensi kearifan lokal yang mendukung pengembangan pariwisata di daerah menjadi bagian dari produk kreativitas manusia yang juga memiliki nilai ekonomi. Tujuan penelitian adalah menganalisis potensi-potensi kearifan lokal yang dapat dimanfaatkan untuk  pengembangan pariwisata berbasis kearifan lokal di Kota Batam, khususnya di wilayah Kampung Tua Patam Lestari yang dapat dikemas dalam bentuk wisata kuliner, wisata bahari dan wisata budaya. Metode penelitian yang digunakan adalah analisis diskriftif yang mendeskripsikan temuan-temuan penelitian berdasarkan data-data yang dianalisis dan kemudian dilakukan penelitian secara mendetail. Sedangkan metode analisa yang digunakan adalah analisa Sternght, Weakness, Opportunity and Threats (SWOT). Analisa SWOT digunakan untuk menganalisa potensi dan permasalahan yang mendukung pengembangan  pariwisata berbasis kearifan lokal di Kampung Tua Patam Lestari. Penelitian ini dilakukan untuk menghasilkan sebuah model alternatif yang dapat digunakan dalam pengembangan pariwisata di wilayah Kota Batam. Potensi kearifan lokal di Kampung Tua Patam Lestari dapat dikembangkan dan dijadikan peluang untuk dapat meningkatkan kesejahteraan masyarakat sekitarnya, juga bermanfaat untuk melestarikan budaya dan ciri khas melayu di Kota Batam.
La Importancia de la Tradición Oral en el Fortalecimiento de Competencias Comunicativas
Authors: Castellanos Monroy Nubia Ernestina
Published: May 2024

La tradición oral desempeña un papel crucial en el fortalecimiento de las competencias comunicativas de las personas. A lo largo de la historia, ha sido fundamental para preservar la cultura, enriquecer el lenguaje y fomentar la cohesión social. Aunque vivimos en una era dominada por la tecnología, es importante reconocer y valorar el impacto perdurable que tiene la palabra hablada en la formación de individuos y comunidades con habilidades comunicativas sólidas. En este orden de ideas, surge el interés de esta revisión investigativa de carácter exploratoria-documental, enfocada en destacar la importancia de la tradición oral en el fortalecimiento de habilidades comunicativas. Para tal fin se tomó como base de consulta 12 documentos, entre artículos científicos y tesis investigativas de Doctorado y maestría. Con el análisis de la información se pudo concretar el interés primordial por la inclusión de la tradición oral en el proceso enseñanza aprendizaje, destacando su valor en la transmisión de la cultura, el desarrollo del lenguaje y la creación de comunidades integradas.
El Desempleo y la Pobreza en Ecuador, Parte de los Problemas Sociales sin Resolver
Authors: Soto Alvarado Fernanda Katherine , Alvarado Guamán Sandra del Cisne , Malla Alvarado Franklin Yovani
Published: May 2024

La investigación analiza la relación entre el desempleo y la pobreza en Ecuador, dos de los problemas más importantes en materia económica y política, utilizando datos del Instituto Ecuatoriano de Estadísticas y Censos (INEC); la metodología utilizada es descriptiva y correlacional; entre los resultados se encuentra una correlación positiva moderada entre el desempleo y la pobreza, lo que sugiere que a medida que aumenta el desempleo, la pobreza tiende a aumentar también. Además, se destaca que el desempleo puede tener un impacto significativo en los ingresos de los hogares más pobres, lo que conduce a una redistribución negativa de los ingresos y a un aumento de los niveles de pobreza. Estos hallazgos subrayan la importancia de comprender la dinámica del desempleo y la pobreza en Ecuador, así como la necesidad de implementar estrategias efectivas para abordar estos problemas socioeconómicos en una economía caracterizada por la falta de recursos para solventar el gasto social.
Rendimiento Académico y Uso de Redes Sociales
Authors: Pachas Huaytan Jorge Vladimir , Abregu Jaucha Washington Neuman , Vega Flores Jorge Alberto , Baldeon Tovar Magno Teofilo , Medina Pelaiza Luz Edga
Published: May 2024

La presente investigación respondió al problema general que fue, ¿De qué manera el rendimiento académico se relaciona con el uso de las redes sociales en los estudiantes de pregrado de la Facultad de Ingeniería en la Universidad Peruana Los Andes?, el objetivo general fue: Determinar la relación del rendimiento académico mediante el uso de las redes sociales en los estudiantes de pregrado de la Facultad de Ingeniería en la Universidad Peruana Los Andes, hipótesis general fue: Existe una relación directa y significativa entre el rendimiento académico y el uso de las redes sociales en los estudiantes de pregrado de la Facultad de Ingeniería en la Universidad Peruana Los Andes. En esta investigación se utilizó el método científico, el tipo de investigación es el aplicado, nivel Correlacional Simple, el diseño es descriptivo–correlacional simple; La población fue 1316 estudiantes de la Facultad de Ingeniería, La muestra fue probabilística de tipo aleatorio estratificado de 298 estudiantes conformada por las cinco escuelas profesionales, siendo ésta su unidad muestral. Se concluye en esta investigación que si existe una relación directa y significativa entre el rendimiento académico y el uso de las redes sociales en los estudiantes de pregrado de la Facultad de Ingeniería en la Universidad Peruana Los Andes, donde los estudiantes del primero al quinto tienen un bajo rendimiento académico de 49.3% uso intermedio en las redes sociales de 57%, y estos resultados determinaron que la X2=11,113 donde se toma la decisión estadística de aceptar la hipótesis alterna.
Konseling Islam Melalui Terapi Berpikir Positif untuk Mengelola Stres Ketua Himpunan dan Organisasi
Authors: Rasyadi Ahmad Fitra , Wardana Mustahar Ali
Published: May 2024

This research aims to determine the process and results of Islamic Counseling through Positive Thinking Therapy to Manage Stress for the General Chair of HMP and UKM at the Faculty of Da'wah and Communication (FDK) Islamic State University of Sunan Ampel  Surabaya (UINSA). This problem was answered by researchers using qualitative research methods by case study analysis general chairs of HMP and UKM at FDK UINSA. The analysis used observation and interview techniques. The counseling process used cognitive restructuring to manage stress of the general chairs of HMP and UKM by changing negative perceptions into positive using thought records. The results of positive thinking therapy showed that there was a change in the connotation of negative thoughts which have been successfully transferred into positive thoughts by the counselee untill can suppress stress due to problems that arise and are felt by the counselee.
Karaciğer Yetmezliği Olan Yenidoğanın Neuman Sistemler Modeline Göre Hemşirelik Bakımı: Olgu Sunumu
Authors: Yücel Adalet , Küçükoğlu Sibel
Published: May 2024

Akut karaciğer yetmezliği (AKY) yenidoğan döneminde %55-70 mortaliteye sahip önemli bir hastalıktır. Bu olgu sunumu AKY ile takip edilen yenidoğana Neuman Sistemler Modeli ve Kuzey Amerika Hemşirelik Tanıları Birliği (NANDA) tanıları ile hemşirelik bakımının sunulması amacıyla yapıldı. Olgu sunumları etik kurul izni gerektirmediğinden yenidoğanın ebeveyninden “Aydınlatılmış Onam Formu” ile onam alındı. Neuman Sistemler Modeli’ne göre hazırlanan veri toplama formuyla hasta bilgileri toplandı. Hasta bilgilerine göre stresörler belirlendi ve öncelikli olarak düşünülen 8 hemşirelik tanısı sunuldu. AKY’nin neonatal dönemde nadir görüldüğü düşünüldüğünde, bu çalışma ile ilk defa AKY olan yenidoğana hemşirelik teori/modellerinin kullanılması ile kanıta dayalı hemşirelik bakımı sunuldu. Sonuç olarak model kapsamında hemşirelik süreci yürütüldü ve hastaya bütüncül bakım verildi.
Examination of Self-Esteem, Self-Confidence, and Social Support Levels in Patients Undergoing Plastic, Reconstructive and Aesthetic Surgery
Authors: Can Öz Yüksel , Duran Songül , Özdeş Rümeysa
Published: May 2024

Objective: This study was conducted to examine the levels of self-esteem, self-confidence, and social support in patients undergoing plastic, reconstructive, and aesthetic surgery.
Methods: This descriptive study was conducted between February and May 2023 in a hospital, involving 152 individuals who underwent plastic, reconstructive, and aesthetic surgery. Ethics committee approval for the research was received from the university. The study utilized a face-to-face survey method. Personal Data Form, “Rosenberg Self-Esteem Scale”, “Coppersmith Self-Confidence Scale”, and “Multidimensional Perceived Social Support Scale (MSPSS)” were used. Percentage, average, t test in independent groups, one way ANOVA analysis and correlation analysis were used to analyze the data.
Results: In our study, the mean score of the individuals on the Self-Confidence scale was determined as 132.13±18.89, and the mean score on the Rosenberg self-esteem scale was determined as 22.77±2.52. The total mean score for the MSPSS was determined as 71.09±14.38. The self-confidence scale score of individuals who were satisfied with their appearance was significantly higher compared to those who were not satisfied (p
A Descriptive Study to Assess the Quality of Life of Patients Undergoing Hemodialysis in Sharda Hospital, Greater Noida
Authors: Chhetri Puja , Chauhan Vashu , . Kesar , Mishra Sanjog , Bhati Anjali , . Ekta , Helena Nongmeikapam , Yadav Shubhangi
Published: May 2024

Background of the Study: Assessment of QoL of patients with ESRD and CKD has been serving a notable purpose in evaluating the influence of the disease on patients. ESRD is a chronic disease condition that significantly degrades a patient’s health-related QoL, mostly because it places barrier on a patient’s health and wellness inclusive of physical health, psychological health, and social health.  Aim of the Study: The main purpose of the research study is to assess the QoL of patients undergoing haemodialysis and to find out the relationship between QoL with selected socio- demographic variables. This study also examines the effects of haemodialysis on patient’s ability to perform activities of daily living (ADLs).  Methods: It is a descriptive study carried out among 50 patients of Sharda Hospital, Greater Noida. Non- probability convenience sampling technique was used. The data was collected through a WHOQOL-BREF assessment scale and a validated, self-designed socio- demographic tool.  Results: The result shows that there is a notable association (p<0.05) between gender and QOL (i.e. males are having better quality of life than females.). Majority 48.0% of the patients describe their overall QoL as fair 38.0% describe it as bad and about 14.0% describe it as good.  Conclusion: The quality of life assessment revealed that approximately half of the patients who participated in the research have rated their quality of life as fair, while a significant portion considered it to be bad and a smaller percentage reported a good quality of life.  Activities of Daily Living: Collectively describes fundamental skills required to independently care for oneself, such as bathing, eating etc.
The Role of Work Motivation as a Mediator in the Influence of Communication and Workload on Employee Performance at Warmadewa University
Authors: SARI Ni Wayan Diah Kartika , DHARMANEGARA I. B. Agung , LAKSMI Putu Ayu Sita
Published: May 2024

The objective of this study is to ascertain the function of work motivation as an intermediary in the impact of communication and workload on employee performance at Warmadewa University. The research at Warmadewa University focuses on the relationship between communication and workload as independent variables, work motivation as a mediating component, and employee performance as the dependent variable. This study used Partial Least Square analysis to ascertain the function of work motivation as a mediator in the impact of communication and workload on employee performance at Warmadewa University. The survey included a total of 248 regular staff that were employed at Warmadewa University, Bali. The research employed the proportionate stratified random sampling approach, with a total of 153 samples. This study utilizes primary data, which was gathered by the distribution of questionnaires to the whole research sample. The research findings indicate that there is a positive and statistically significant correlation between communication and employee performance at Warmadewa University. The workload has a detrimental and statistically significant impact on employee performance at Warmadewa University. The relationship between communication and job motivation of employees at Warmadewa University is both favorable and substantial. The workload has a detrimental and substantial impact on the work motivation of employees at Warmadewa University. Work motivation positively and significantly impacts employee performance at Warmadewa University. Work motivation acts as a mediator between communication and employee performance at Warmadewa University. Similarly, work motivation also acts as a mediator between workload and employee performance at Warmadewa University.
The Influence of Motivation and Physical Work Environment on the Performance of PT Employees BPR Sari Jaya Sedana with Organizational Commitment as a Mediation Variable
Authors: RENY Reny , SARA I Made , DHARMANEGARA Ida Bagus Agung
Published: May 2024

In facing diverse competitors, companies must understand that the quality of performance does not only depend on technology, but also on the ability and motivation of its human resources. In order for human resource management, which according to experts is the art of managing employee relationships and roles effectively and efficiently, to be applied to an organization or company, management must also understand the motivation of employees, the ideal conditions of the physical work environment that employees expect and organizational commitment. created within an organization or company. This research aims to analyze the influence of Motivation, Physical Work Environment on Employee Performance through Organizational Commitment at PT. BPR Sari Jaya Sedana. The population used is all employees of PT. BPR Sari Jaya Sedana. The number of samples used was 30 employees with sampling techniques using saturated techniques. The data analysis used in this research is inferential analysis using SEM-PLS. The results of this research show that motivation has a positive and significant effect on employee performance. Motivation has a positive and significant effect on Organizational Commitment. The physical work environment has a positive and insignificant effect on employee performance. Physical Work Environment has a positive and significant effect on Organizational Commitment. Organizational Commitment has a positive and significant effect on Employee Performance. Organizational Commitment partially mediates (partial mediation) the influence of motivation on employee performance. Organizational Commitment is a perfect mediator between the influence of the Physical Work Environment on PT Employee Performance BPR Sari Jaya Sedana.