bluuebunny/crossref_metadata_2025 huggingface dataset:
Coomb's negative cold agglutinin disease
Authors: Balraam K. V. Vinu , Masood Adnan , Garg Nidhi , Somasundaram Venkatesan
Published: November 2021

Cold agglutinin disease (CAD) is a rare type of autoimmune hemolytic anemia which usually results due to production of immunoglobulin M-type autoantibody against the I/i and H antigens on red blood cell membrane. They can be idiopathic or may be due to underlying lymphoproliferative disorders or atypical infections. It can have a varied presentation ranging from being incidentally detected to being totally transfusion dependent for a longer or shorter duration. Several factors play a role in determining the ability of cold agglutinins in inducing hemolysis such as antibody concentration and temperature. Here, we present a 54-year-old patient, a known case of chronic obstructive pulmonary disease who was admitted to our hospital in the winter months as a case of alcohol withdrawal syndrome. During the course of the stay, the patient developed respiratory insufficiency and went into Type II respiratory failure and hematological investigations revealed features of CAD.
SYSTEM OF INTELLIGENT MEASUREMENT AND CONTROL FOR THE CONDITION OF MOVING OBJECTS
Authors: BEKİROVA Lala , BAYRAMOV Aladdin
Published: November 2021

An intelligent system that monitors the speed and condition of a moving object is designed to reduce the risk of potential threats that may arise with autonomous decision-making capabilities depending on the situation and exchange information with databases via remote network sensors. Risk assessment based on information obtained from stationary metering stations installed at intersections and control crossings, object characteristics parameters and side-effect parameters, alerting the central management system based on the results, and making decisions on regulating the speed of the facility, depending on the level of danger and whether the decision is approved by the center, providing information about the facility on the board, sending alerts to security systems at intersections, and identifying opportunities for change by influencing decisions based on risks The characteristic technical parameters of the inflated object depend on internal and external factors and making appropriate decisions according to the risk assessment, etc. information on processes, monitoring, and control. Monitoring of working conditions with the participation of the remote control wireless sensor network in the central control room.
Stress and its Impacts among Pastors in the Moravian
Church of Tanzania
Authors: Angetile Madaraka
Published: November 2021

This study sought to establish stress and its potential impacts among pastors in the Moravian Church of Tanzania. The study adopted the mixed methods research approach whereby interview schedule and closed-ended questionnaire gathered data from respondents. The study comprised of 41 out of 120 population of pastors selected through simple random sampling, including one Bishop, four provincial and district leaders and thirty-six church pastors. Disagreement between church members and pastors was found to be one of stressors to pastors. It is therefore high time to intervene with strong means and alternatives so that pastors work in supportive environments. In order to enhance working morale among pastors it is essential to keep them motivated. Furthermore, the Moravian Church of Tanzania needs to review policies on working conditions so that pastors will work comfortably. The church should also establish regular seminars and trainings to educate pastors on essential skills, such as leadership and financial management in order to reduce unnecessary conflicts with church members and leadership as the conflicts are the causatives of stress.
Perception of Secondary School Teachers on Sources of Stress and Coping Strategies: A Case of Ludewa District, Tanzania
Authors: Thomas Amina
Published: November 2021

The study aimed at identifying perceived sources of stress and coping strategies among secondary school teachers in Ludewa District. The study was guided by Transactional or Cognitive Theory of Psychological Stress and Coping. It employed the quantitative approach through descriptive statistics in terms of frequencies and percentages. Through simple random sampling, eight out of 22 schools were selected to participate in the study. From the eight schools, 100 teachers were selected through simple random sampling but the response rate was 74. Therefore, 74 teachers participated to fill the questionnaire. The first category of perceived stressors is for those which were very highly rated: delay in promotion, poor working condition, low salary for work, worried from student performance, overwork and lack of time to spend with family. The second category is for those which were highly rated: poor administrations, lack of social services, loans from different organizations, benefit from work and students’ misbehavior. Lowly rated source of stress was attending duties on weekends while very lowly rated sources were little acknowledgment from superior and trouble with colleagues. The study gives a number of recommendations; these include that the government should employ more teachers to reduce teachers’ overwork which is cited as one of stressors. Heads of schools should involve all teachers in decision making and treat them equally. School under investigation should employ mentoring and counseling techniques which will motivate teachers to share their economic and social problems in order to curb unnecessary stresses. Finally, teachers should employ such stress management strategies as joining in social clubs, attending physical exercises like sports and games and seeking support from either co- workers or supervisors in order to curb stressful challenges.
Buying Eyewear Online. Three principles to buy a pair of glasses or focal points online: utilize the wide reach accessible, an incentive for cash, and client care administration
Authors: Claro Pedro
Published: November 2021

There is such a lot of that you can do with the assistance of a PC and a web association in this day and age. With web based business, online stores, various transportation and installment offices, there is minimal that you can't accepting from the Web. With a single tick of the mouse, you can have practically all that you need from the solace of your own home. So next time you intend to buy your eye stuff, for example, contact focal points, eyeglasses, shades, take a stab at doing as such sitting at home. Most brands of eyewear have started to bring to the table their items on the web.
You could very well discover the brand you have believed this load of years having a web based buying office. Notwithstanding them, you will discover a large group of different brands offering arranged items.
With such a great amount to look over, you may get somewhat befuddled at first. So here is a little aide on the best way to pick the right eye embellishment for yourself.
There are three principle standards that you need to recollect while purchasing a couple of eyeglasses or focal points. They are as per the following.
Inflación y rendimientos en mercados emergentes: el caso de Argentina
Authors: Pesce Gabriela , Pedroni Florencia Verónica
Published: November 2021

El objetivo del presente trabajo es realizar un análisis preliminar de la teoría de fijación de precios por arbitraje en el mercado de capitales argentino, haciendo especial hincapié en la inflación como variable de interés para un país emergente, un mercado poco desarrollado y un período bajo análisis con tendencias inflacionarias e intervención del mercado cambiario. Para ello se trabaja con un enfoque de base teórico-empírica. A efectos de plantear el modelo formalmente se realiza un abordaje teórico del tema, con base principalmente en artículos científicos vinculados a la relación entre la tasa de rendimiento de activos y la inflación. El análisis empírico está centrado en un estudio econométrico del rendimiento de las acciones de 19 empresas que cotizan en el mercado de capitales argentino entre 2005-2014 y las vinculaciones con variables de interés, en especial macroeconómicas, incluyendo algunas pruebas de control con variables microeconómicas. Los resultados principales son robustos en relación al efecto sobre el rendimiento de las firmas de las variables explicativas: rendimiento libre de riesgo, rendimiento de mercado, efectos temporales de períodos “bisagra” y efectos sectoriales. Sin embargo, los resultados no son determinantes en el efecto de las variables inflación y tipo de cambio sobre el rendimiento de las acciones.
China-Pakistan Economic Corridor: Analytical overview on Socio-Cultural Romance between China and Pakistan
Authors: Asif Muhammad , Ali Majid , M’Begniga Abdoulaye , Guoqing Zhou , Yang Liu , Hashim Muhammad
Published: November 2021

China Pakistan Economic Corridor (CPEC) is an important Belt and Road Initiative (BRI) project that integrates many countries. The CPEC project will play a vital role to make more strong relationship between China and Pakistan. CPEC project will enhance cooperation between Pakistan and China in field of socio-cultural and regional Bilateral Cooperation and exchange. Despite growth between two countries in the economic and trade field, there is a vital area to explore the cultural exchange, cooperation, and communication needed to improve from both sides. In this theoretical study method, the data has been obtained from primary and secondary sources. The primary sources consisted of books, official databases of China and Pakistan, MoU signed b/w both countries, etc., as the secondary sources consisted of research papers, newspapers, journals, online databases, etc. This paper has an analytical overview of the time value and general cultural and artistic exchanges between China and Pakistan. Further, the paper discussed the relationship between literature, art, and economics. In this paper, researchers have also examined the significant role of people-to-people contact for socio-cultural exchange and cooperation between China and Pakistan.
Japan's priorities in Taiwan: Its impacts on Japanese relations with America and China
Authors: Usman Sahibzada Muhammad , Khalid Yamama
Published: November 2021

America-Japan partnership is now at the core of the America-led defence system in the East Asia. The unresolved state of Taiwan is already one of the worst security conditions in the region in the terms of this partnership. It may contribute to a big confrontation of one or both countries with China. The broader Taiwan-Japan-China-America ties usually regard Taiwan and Japan as the least influential combination imaginable. Despite this fact, the depth of engagement, hard to categorize and with great potential to affect stability and security in the field, is reversed from this tertiary regional connection. Therefore, Japan's major goal to balance the power with Taiwan is to preserve and develop constructive de-facto state-to-state ties between the liberal and democratic powers of similar consciousness, both of which are scared of the Chinese control. This paper discusses the specific ties between Japan and Taiwan in conjunction with Japanese domestic priorities and analyses the repercussions for America-Japan cooperation in the future. Especially about Japan, the American and Taiwanese governments should identify areas of difference early on and resolve emerging issues within the alliance's auspices.
COVID-19 Pandemic and Mode Choice of Alabamian Truck Drivers’ Mobility to Grocery Shopping
Authors: OLUWOYE JACOB
Published: November 2021

Background:  In late December 2019, COVID-19, commonly referred to as the Coronavirus was identified in China because of the main explanation for recent human respiratory health cases. The virus was first detected in Wuhan City, and during a space of months, it had covered the whole globe. The virus has engendered huge drastic changes to world healthcare, economic, transportation, and education systems around the world.
Purpose: The general purpose of this study was to investigate the intersection of demographic characteristics and how truck drivers view change in their grocery shopping (CGS) under the COVID-19 circumstances of selected counties in Alabama. Specifically, the objectives of the study are to (1) examine if there is any relationship between marital status (MS) and CGS and (2) know and assess the choice of transport mode used for grocery shopping during the covid-19 pandemic
Methods: The research paper's goal necessitated the truck drivers’ views regarding commuting to the workplace. Following a summary of the literature review research phase, the researcher conducted a variety of semi-structured interviews with truck drivers in Alabama through Survey Monkey by a postgraduate student in June-July 2020. Overall, 50 truck drivers have completed the survey. The info was stored on Survey Monkey servers within the Center for Urban and Rural Research (CURR), Department of Community and Regional Planning, Alabama A&M University.
Results: The data analysis reveals their main workplace before the COVID-19 pandemic 94% of the truck drivers residing in Alabama especially from Jefferson county provided information about commuting to workplaces, while 4% to the places of educations (lecture room0 and a couple of production sites. Furthermore, 92% of the truck drivers reported NO change within the means of transport in commuting trips during the COVID-19 pandemic, while 8% indicated changes within the means of transport.
Implications: This research paper contributes important new empirical analysis of the truck drivers’ views regarding commuting to the workplace under the COVID-19 pandemic to some extent where there's an abundance of conceptual papers and opinion pieces but still scant evidence on the particular road safety of the pandemic for researchers to think about on potential person and situation factors related to COVID-19 that would affect road safety during and after the pandemic. Collaborative efforts by researchers and public and personal sectors are going to be needed to collect data and develop truck drivers' road safety strategies in reference to the new reality of COVID-19. Keywords: COVID‐19, health disparities, roadway safety, syndemics, truck driver
Central Serous Chorioretinopathy: A Review of Pathogenesis, Risk Factors, Diagnostic Methods and the Current Treatments
Authors:   Saglik Bilimleri University, Ulucanlar Eye Hospital, Ankara Turkey, Kocak Altıntas Ayse Gul
Published: November 2021

Central serous chorioretinopathy (CSCR) is characterized by serous detachment of the neurosensory layer at the macula. It has a relatively high recurrence rate and mainly affecting middle-aged males. The etiology and pathogenesis of the disease still remain ambiguous. But choroidal changes which increase choroidal vascular permeability are the basic pathology of CSCR. Different diagnostic methods such as FAF, FFA, OCT, OCTA, ICG could be used to detect its biomarkers such as choroidal thickness, choroidal vascularity index, hyperreflective dots for exact diagnosis and treatment response. Acute CSCR generally self-limited, but in recurrent or chronic forms may cause permanent visual loss due to progressive and irreversible damage in the photoreceptor layer of retinal pigment epithelium atrophy. Several treatment alternatives have been reported, such as PDT, intravitreal Anti-VEGF, TTT, Laser, Mineralocorticoid receptor antagonist for chronic and recurrent CSCR.
An Overview of an Invasive Fungal Infection In Covid-19: Mucormycosis
Authors:   Bachelor of pharmacy, NGI College of Pharmacy, NGI Campus, NH-58, Near Sardar Vallabh Bhai Patel Agriculture University, Modipuram, Meerut, 250110, Uttar Pradesh, India, shu Himan , kumar Mukesh ,   Department of Pharmacy, Kharvel Subharti College of Pharmacy, SVSU, Subhartipuram NH-58, Delhi-Haridwar Bypass Road, Meerut, Uttar Pradesh 250005 India
Published: November 2021

Mucormycosis is an invasive fungal infection of zygomycetes class, comprised the orders of entomophtherales and mucorales which is common infection in immuno compromised patients, especially in stem cell transplantation, hematological malignancy and diabetes mellitus. It is the third invasive fungal infection after aspergillosis and candidiasis both strain belong the class of zygomycetes. Mucormycosis generally transmitted in humans by the inoculation and inhalation of spores in mucous membrane as well as skin. After the deadly outbreak of corona virus, this infection has taken a different form in those patients who suffer from the covid-19 which is categorized as a post covid-19 disease. Aim of this review to highlight the recent awareness about invasive fungal treatment.
Coronavirus Vaccine: A Cross-Sectional Study of Its Adverse Events
Authors:   Postgraduate student Government College of Dentistry Indore, India, Jain Srishti , Jain Sandhya ,   Professor and HOD Government College of Dentistry Indore, India
Published: November 2021

Aims and Objectives: This study aims to assess the effects of COVISHIELD vaccine on humans after first dose of vaccination. In this study we have evaluated vaccine’s effect after first dose on health officials in central India.
Effectiveness of Hydroxyurea in the Management of the Painful Crisis in Sickle Cell Anemia
Authors:   Department of Pharmacy Practice & Medicinal Chemistry, Jyothishmathi Institute of Pharmaceutical Sciences, Thimmapur, Karimnagar 505481, Telangana, India, S D Shanmugakumar , Amithkumar CH ,   Department of Pediatrics, Prathima Institute of Medical Sciences, Nagnoor, Telangana – 505417, India
Published: November 2021

Background: Sickle cell syndromes are inbred disorders distinguished by the presence of blade (Sickle) hemoglobin in red blood corpuscles. The sickling of red cells in patients with SCA is caused by the polymerization of molecules of non-oxygenated hemoglobin S (α2ß2s) into rigid rod-like polymers. In the open-label study of hydroxyurea therapy, the synthesis of embryo hemoglobin increased in most patients with SCA resulting in a humane myelotoxicity and rise in painful crises. By suppressing the sickling process, increased levels of embryo hemoglobin sinew the less frequency of painful crises.
Информационно-аналитическое обеспечение управления за-тратами на производство продукции в сельскохозяйственных организациях
Authors:   Кубанский государственный аграрный  университет имени И.Т. Трубилина, Говдя В.В. , Дегальцева Ж.В. ,   Кубанский государственный аграрный  университет имени И.Т. Трубилина, Величко К.А. ,   Кубанский государственный аграрный  университет имени И.Т. Трубилина
Published: November 2021

В монографии рассматривается проблемы информационно-аналитического обеспечения управления затратами в экономических субъектах аграрного сектора экономики. Представлены основные направления использования цифровых методов и инструментов формирования информационного поля на основе натуральных и стоимостных дескрипторов учетной триады. Предназначена для студентов, аспирантов, научных работников, преподавателей, руководителей и специалистов хозяйствующих субъектов аграрного сектора экономики.
A ATUAÇÃO DO FISIOTERAPEUTA NA SAÚDE DO HOMEM: UM ESTUDO DE CASO
Authors: Larchet Rebeca Bonfim , Amorim Patrícia Brandão
Published: November 2021

Introdução: A população masculina tornou-se uma grande preocupação dos serviços públicos de saúde, devido ao alto número de enfermidades graves e crônicas que afetam esse gênero, onde a falta de uma atenção à saúde adequada aumentam ainda mais esses agravos, além disso, quando comparado a mulher, o homem possui uma taxa de morbidade e mortalidade bem maior, por isso o Ministério da Saúde elaborou uma Política Nacional de Atenção Integral ao Homem. Dentro dessa política há atuação do profissional da Fisioterapia como integrante principal no processo de promoção, prevenção, promoção e reabilitação da saúde do homem desempenhando um papel fundamental. Objetivo: Diante disso, essa presente pesquisa tem como finalidade apresentar a atuação do Fisioterapeuta na Saúde do Homem, além de apresentar a importância desse profissional nesse grupo da população. Metodologia: A metodologia se dividiu em duas etapas, a primeira ocorreu uma revisão bibliográfica sobre o tema com a fundamentação em revisões bibliográficas, análises em sites confiáveis, leis e artigos científicos, na segunda etapa foi aplicado um questionário a 4 Fisioterapeutas que atendem no município de Nanuque, no Estado de Minas Gerais, onde foi abordado questões voltadas a visão e o papel desses profissionais frente a Saúde do Homem no seu município, sobre a Política Nacional de Atenção ao Homem, as principais doenças e as particulariedades desse público alvo.   Conclusão: Ao término do trabalho ficou evidenciado que os objetivos propostos para o estudo foram suficientes, pois, foi possível identificar as diversas funções do Fisioterapeuta na Saúde do Homem.
A New Algorithm Based on Bernstein Polynomials Multiwavelets for the Solution of Differential Equations Governing AC Circuits
Authors: Pandey Shweta , Dixit Sandeep , Verma Sag R
Published: November 2021

We extend the application of multiwavelet-based Bernstein polynomials for the numerical solution of differential equations governing AC circuits (LCR and LC). The operational matrix of integration is obtained from the orthonormal Bernstein polynomial wavelet bases, which diminishes differential equations into the system of linear algebraic equations for easy computation. It appeared that fewer wavelet bases gave better results. The convergence and exactness were examined by comparing the calculated numerical solution and the known analytical solution. The error function was calculated and illustrated graphically for the reliability and accuracy of the proposed method. The proposed method examined several physical issues that lead to differential equations.
HIGHLIGHTS

Differential equations governing AC circuits are converted into the system of linear algebraic equations using Bernstein polynomial multiwavelets operational matrix of integration for easy computation
The convergence and exactness were examined by comparing the calculated numerical solution and the known analytical solution
The error function is calculated and shown graphically

GRAPHICAL ABSTRACT
Effect of the Cultivation Systems and Split Fertilizer Applications on the Growth and Yields of Tatsoi (Brassica rapa subsp. narinosa)
Authors: Kartika Kartika , Lakitan Benyamin , Ria Rofiqoh P. , Putri Hana H.
Published: November 2021

Tatsoi [Brassica rapa subsp. narinosa (L.H.Bailey) Hanelt] is a leafy vegetable with potential for cultivation in a riparian wetland ecosystem. The floating culture system has the advantage of ensuring a sufficient water supply in the growing substrate due to the continuous upward water movement caused by capillarity force. This study evaluated the responses of the tatsoi plant to split fertilizer applications under conventional cultivation and floating culture systems. The fertilizer treatments consisted of control (F0), single (F1), split into 2 (F2), split into 3 (F3) or split into 4 applications (F4). The results showed that early growth of tatsoi was better using floating culture than the conventional system. However, tatsoi adapted well to conventional and floating culture systems as long as sufficient nutrients were available. A single application of 6 g NPK fertilizer (16:16:16 v/v/v) at transplanting provided sufficient nutrients, as indicated by the number of leaves, total leaf area, canopy area, stem dry weight, and leaf dry weight at harvest. The leaf SPAD values in the tatsoi plants were higher in the floating culture system than in the conventional system at 14 and 20 DAT fertilized with a 4-split application. Transplanting occurred 14 days after seed planting (DAP), and harvest occurred 49 days later. A quadratic regression model using leaf length (L), leaf width (W), or L×W as predictors was reliable for non-destructive leaf area estimation in the tatsoi plant. It is recommended for farmers to apply a single NPK fertilizer at the rate of 6 g/plant to achieve an optimum yield in tatsoi cultivated using a conventional or floating culture system.

HIGHLIGHTS

Tatsoi plant grew well under conventional and floating culture systems as long as sufficient nutrients were available

Splitting fertilizer into several times of application did not significantly better than single application of NPK fertilizer at time of transplanting

SPAD values in the tatsoi leaves were higher in the floating culture than in the conventional system

Length and width of leaves were reliable predictors for non-destructive accurate leaf area estimation in the tatsoi plant

GRAPHICAL ABSTRACT
Preliminary Study: Immediate Effect of the Slow Deep Breathing Exercise and Sustained Maximal Inspiration with Volume-Oriented Incentive Spirometry on the Diffusing Lung Capacity in Healthy Young Participants
Authors: Yankai Araya , Leelarungrayub Jirakrit , Kanthain Rungtiwa , Laskin James J
Published: November 2021

Slow-deep breathing exercise (SDBE) while using a volume-oriented type of incentive spirometry (VIS) device (SDBE/VIS) is one of the techniques in chest physical therapy designed to improve lung volume and oxygenation. However, the immediate effect of SDBE/VIS paired with a sustained maximal inspiration (SMI) on diffusing lung capacity (DLC), has not been documented. This preliminary study aimed to evaluate the immediate effect of SDBE/VIS paired with the SMI technique on DLC in healthy participants. Twenty healthy sedentary adults (11 males and 9 females) aged 20 to 23 years were recruited into this cross-over study and randomly assigned to one of 2 ordered groups; SDBE/VIS paired with SMI followed by SDBE/VIS alone or SDBE/VIS alone followed by SDBE/VIS with SMI. During each of the 2-testing sessions, the participants performed 3 sets of 5 SDBE/VIS trials which were controlled by ensuring that each participant reached their maximal vital capacity; derived from their pulmonary function test. The DLC for carbon monoxide (DLCO), alveolar volume (VA), and total lung capacity (TLC) was assessed prior to (baseline) and after each of the 5 experimental trials. A 3-min rest period was given between each set of 5 trials and 1 week between testing sessions.

The results demonstrated that SDBE/VIS paired with the SMI technique significantly increased both the DLCO (mL/min/mmHg and %) and VA (L and %) when compared to the baseline values. Whereas, SDBE/VIS without using the SMI technique did not alter the DLCO, VA or the DLCO/VA. However, both SDBE/VIS with and without the SMI technique showed a significant increase the TLC (L and %), with the TLC from SDBE/VIS paired with SMI was significantly higher than when the SDBE /VIS was performed without using the SMI technique. Thus, it appears that performing SDBE/VIS exercised paired with the SMI technique has a significant and positive effect on DLC.
Isoniazid-Isatin Hydrazone Derivatives: Synthesis, Antitubercular Activity and Molecular Docking Studies
Authors: Santoso Mardi , Fahmi Muhammad Riza Ghulam , Kurniawan Yehezkiel Steven , Ersam Taslim , Fatmawati Sri , Martak Fahimah , Fadlan Arif
Published: November 2021

This study examined the synthesis of isoniazid-isatin hydrazone derivatives 5-7, followed by an investigation on the in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv, and molecular docking. A yield of 81 - 92 % of these compounds was achieved, with structural characterization by spectroscopic methods (FTIR, NMR, HRMS). The in vitro antitubercular activity was evaluated against M. tuberculosis H37Rv, and the highest effect was observed in compound 7, with a minimum inhibitory concentration (MIC) of 0.017 mM, lower than rifampicin (MIC 0.048 mM), which served as the positive control. In addition, the molecular docking of 5-7 was performed to visualize the interaction of isoniazid-isatin hydrazone derivatives with the active site of InhA receptor, which was in agreement with the experimental data. The hydrogen bonding with Ser94 and pi-pi interaction with Phe41 and/or Phe97 on the InhA active site was pivotal for the antitubercular activity.
HIGHLIGHTS

Tuberculosis caused by Mycobacterium tuberculosis is one of the top ten leading causes of death globally
The first and second lines of antituberculosis drugs are the prevalent treatment for this disease, but they show several drawbacks and are exacerbated by the occurrence of drug resistance
The isoniazid-isatin hydrazone derivatives were designed through molecular hybridization and synthesized effectively and exhibited moderate to high activity against tuberculosis H37Rv
Molecular docking study demonstrated that the hydrogen bonding with Ser94 and the pi-pi interaction with Phe41 and/or Phe97 are important for antitubercular activity

GRAPHICAL ABSTRACT
Structural Modification of the Macrolide Brefeldin A to Analogues with Enhanced Cytotoxicity against KB Cells
Authors: Namsa-Aid Maneekarn , Wiyakrutta Suthep , Prachya Surasak , Namsa-Aid Anucha , Suksamrarn Apichart
Published: November 2021

The macrolide brefeldin A (BFA, 1) exhibited high cytotoxicity against KB cells. However, it was also toxic against non-cancerous cells. In order to lower toxicity against normal cells while maintaining the cytotoxic potency to the cancer cells, structural modification of this compound was undertaken. Starting from compound 1, the analogues 2-13 were synthesized and evaluated for cytotoxicity against KB cells. The analogue 2 exhibited the most potent cytotoxicity against KB cells, with an IC50 value of 0.034 nM, 67-fold more active than its parent compound 1. It was 41764 and 8235 fold more active than the standard drugs ellipticine and doxorubicin, respectively. The higher cytotoxicity against KB cells and lower toxicity against Vero cells of analogue 2 than those of the parent compound 1 contributed to its exceptionally high selectivity index of 9117. The results suggested that this analogue might be utilized to develop a new candidate for an anticancer drug.
HIGHLIGHTS

Oral cancer is a major worldwide public health issue and may affect any oral cavity region, including the lips, tongue, mouth and throat
The ester analogues (2-13) were the first report of the cytotoxic against human epidermoid carcinoma (KB) cells
7-O-acetyl BFA (2) exhibited the most potent cytotoxicity against KB cells, with an IC50 value of 034 nM, 67-fold more active than its parent compound 1
The essentially structural features for the macrolide of BFA-type to exhibit high cytotoxicity against KB cells are the presence of a free hydroxyl group at the 4-position, a free hydroxyl group or the corresponding ester at the 7-position, and unsaturated functions at the 2- and 10-positions

GRAPHICAL ABSTRACT
Purification and Characterization of an Extracellular Lipase Produced by Aspergillus oryzae ST11 as a Potential Catalyst for an Organic Synthesis
Authors: Paitaid Pattarapon , Buatong Jirayu , Phongpaichit Souwalak , H-kittikun Aran
Published: November 2021

The lipase producing Aspergillus sp. ST11 was identified by molecular and morphological methods. The primers ITS1/ITS4 were used for amplifying the ITS region. It showed that the strain was grouped with Aspergillus oryzae and Aspergillus flavus (98 % bootstrap value). The colony morphology of Aspergillus sp. ST11 on malt extract agar and Czapek yeast agar showed a characteristic of A. oryzae. Therefore, it was identified as Aspergillus oryzae ST11. The lipase produced by the strain was purified and characterized. The purification steps involved precipitation with chilled acetone and separation by column chromatography, with HiTrap® Q HP and Toyopearl Butyl-650M, respectively. After purification, the lipase activity was increased 13 fold and with 7.9 % yield. Its molecular mass was 25 kDa. The purified lipase was stable at a pH between 5.0 - 8.0 and had optimum activity at pH 7.5. It was stable at 30 °C and had optimum activity at 37 °C. Its activity was promoted in the presence of Mg2+ but it was greatly decreased in the presence of Co2+, Cu2+, Hg2+ and Zn2+. Surfactants (Triton X-100, Tween-80, Tween-20, arabic gum, and sodium dodecyl sulfate) showed negative effects on lipase activity, while inhibitors (PMSF, EDTA, and β-mercaptoethanol) did not reduce the activity significantly. Polar solvents, such as methanol and ethanol, had much negative effect on lipase activity compared to non-polar solvents, such as hexane and isooctane. The concentrated lipase from A. oryzae ST11 was used to catalyze the transesterification and gave the highest bioconversion (90 %) after 24 h.
HIGHLIGHTS

Extracellular lipase produced by Aspergillus oryzae ST11 could be applied in many applications which is more flexible compared with the use of whole-cell biocatalysts
High stability toward a wide range of pH and temperature obtained from this extracellular lipase
The concentrated lipase shows the capability to produce the high biodiesel from natural oil

GRAPHICAL ABSTRACT
'I Would Say I Am Austrian but …' - Multiple Spatial Belongings and Hybrid Identities among Young People in Vienna, Austria
Authors:   University of Vienna, Austria & Austrian Academy of Sciences, Schnelzer Judith , Hintermann Christiane ,   University of Vienna, Austria, Kern Isabel ,   University of Vienna, Austria
Published: November 2021

Young people who live in or attend school in Vienna grow up in multicultural environments, as immigration has shaped the Austrian society over the last decades. In public debates, migrants and their descendants are repeatedly called on to “integrate”, while their feelings of belonging to Austria are questioned. Drawing from discussions on hybrid and multiple identities, this study explores the spatial dimension of identity constructions of students in Vienna aged between 14 and 19 years. Quantitative data from a comprehensive online survey and qualitative data from group discussions reveal that multiple spatial belongings on different scales are the rule and not the exception among young Viennese. Furthermore, on a national level, participants identify with Austria to a much larger extent than with any other country. Findings emphasise the need for a mixed-methods approach when researching questions of identity constructions. Fieldwork experiences furthermore show that young people are highly interested in discussing the topic, as they are confronted with these issues on a daily basis.
HARPUT SAĞIR MÜFTÜ KONAĞI ONARIMI HAKKINDA BİR DEĞERLENDİRME
Authors: ÖZTÜRK Şahabettin
Published: November 2021

Orta Çağ da doğu ile batı, kuzey ile güney kervan ve ticaret yollarının kesiştiği uğrak bir yer olan Harput her dönemde önemini korumuştur. Harput’ta mimari yapılaşmanın önemli bir unsuru olan geleneksel sivil konut mimarisi XX. yüzyılın başlarına kadar kesintisiz bir şekilde gelişme göstermiştir. Harput’taki geleneksel konutlar tek ve iki katlı, düz toprak damlı, kerpiç kullanılarak bitişik ya da ayrık nizamda inşa edilmiştir. Harput kent mahalle yapılanmasında halkın ekonomik, kültürel, sosyal durumu, dini yapısından ziyade arazinin topoğrafik yapısı ön plana çıkmıştır. 1900 yılının ilk çeyreğinden sonra Aslan Dağı eteklerindeki kurulu Harput’taki mimari gelişim güneydeki Elazığ yerleşim alanına inerek mimari form, fonksiyon, yapım malzemesi ve yapım tekniğinde yapısal değişikliğe uğrayarak inşa edilmiştir. 1950 yılından sonra Harput önce ilçeye sonra hızla gelişen ve değişen Elazığ şehrinin bir mahallesine dönüşmüştür. Harput’taki mimari yapılaşmanın tamamen durması, değişen sosyal hayat şartları halkın betonarme evleri, geleneksel evler tercih etmesi sonucu geleneksel evler terk edilerek birer birer yıkılmıştır. Tarihi Harput’tun Koruma İmar Planı’nın 2010 yılına kadar hazırlanmayışı, tespit ve tescil yapılmaması olumsuz süreci hızlandırmıştır. Çalışma kapsamında değerlendirdiğimiz Harput Sağır Müftü Konağı, mimari özellikleri bakımından iki katlı iç sofalı, ikiyüzlü, ikiden fazla odalı, şahnişinli plan içerisinde yer almaktadır. XIX. yüzyıl ortalarında inşa edildiği düşünülen konak, 2000 yılına kadar kullanılmıştır. 2007 yılına kadar ticari işletme olarak kullanılan yapının üst katı, düz dam örtü sistemi ve iç bölümlerinde bazı ciddi yapısal strüktürel sorunlar olmuştur. Tescilli olan konak Elazığ Belediyesi tarafından kamulaştırılmış ve onarımı 2010 yılında tamamlanmıştır.
Evolution of Distributed Transaction Towards Microservices Architecture
Authors: Gorivale Divya Ramesh
Published: November 2021

Major evolutions have took place starting with primary structure counting on initiated request via way of means of a customer to a processing facet known as the server. Such architectures had been now no longer sufficient to manage up with the quick ever-growing range of requests and want to make use of community bandwidth. Mobile sellers tried to triumph over such drawbacks however did cope up for see you later with the developing era platforms. Service Oriented Architecture (SOA) then developed to be one of the maximum a success representations of the customer-server structure with an introduced commercial enterprise price that offers reusable and loosely coupled services. SOA did now no longer meet clients and commercial enterprise expectancies because it changed into nevertheless counting on monolithic systems. Resilience, scalability, rapid software program shipping and the usage of fewer assets are incredibly applicable features.
Ethnomedicinal Plants Used for Cure of Sexual Dysfunctions in Humans by Traditional Hakeem’s of Malegaon Region from Nasik District.
Authors: Tausif Shaikh , Mumtaz Baig
Published: November 2021

Hakeem is an Arabic word meaning “Physician” or “Practitioner of herbal medicine”. Hakeems are practice Unani medicinal system i.e. the Greco Arabian system of medicine or Islamic medicine. Most of the Hakeems are practice on sexual disorders like Decrease in sperm count, decrease of viscosity of semen, erectile dysfunction, pre mature ejaculation and fluidity of sperms are common sexual dysfunctions of males and Leucorrhoea, Amenorrhea and Lactational amenorrhea (Postpartum infertility) are the common sexual dysfunctions of females of human being. The present study on these diseases is based on the collection of data from Hakeems of Malegaon region who practicing on these diseases from generations about 90 to 150 years.
Proapoptotic Protein Smac Mediates Apoptosis in Ovarian Cancer Cells When ‎Treated with the Carpachromene ‎
Authors: Song Yunjing , Wang Jian , Zhang Chunnian , Yu Ying , Cai Hong
Published: November 2021

Introduction

We also investigated the Carpachromene in the cytotoxicity studies against common human ovarian cancer cell ‎line i.e., SW 626, in-vitro.

Material and methods

Cell viability of Carpachromene was very low against common ‎human ovarian cancer ‎cell line i.e. SW 626 without any cytotoxicity on normal cell line. To compare the ‎biological activities of molecules, the enzymes used are α-glucosidase, acetylcholinesterase, respectively. Finally, ‎calculations were made using the molecular docking method to compare the biological activity of the ‎carpachromene molecule. We then examined whether the release of Smac is necessary for apoptosis in ovarian ‎cancer cells using the SW 626‎ cell line. We first examined mitochondrial and cytosolic Smac levels after ‎Carpachromene treatment. ‎

Results

Following the docking calculations, the properties of the carpachromene molecule ‎were examined by ADME/T analysis in order to be used as a drug in the future. In addition, the anti-oxidant ‎properties of the molecules were examined in both gas and water phase with the HF/6-31g basis set with the ‎Gaussian software program. As shown, exposure of ovarian cancer cells to Carpachromene decreased ‎mitochondrial Smac and increased cytosolic Smac levels in a time-dependent fashion. As depicted in results, a ‎decrease in Smac expression was confirmed by Western blot. Silencing of Smac significantly inhibited ‎Carpachromene-induced caspase-3 cleavage and attenuated apoptosis in these cells Moreover, overexpression of ‎a Smac heptapeptide (Smac-N7) enhanced Carpachromene-induced cell death

Conclusions

According to the above findings, the Carpachromene may be administrated for the treatment of several types of ‎human ovarian cancer in humans. ‎
Sunflower productivity depending on the level of mineral nutrition in the conditions of the Ryazan region
Authors: Makarova Marina , Vinogradov Dmitry , Pashkang Natalia , Gogmachadze Guladi
Published: November 2021

The article offers research on the study of mineral nutrition levels on sunflower productivity in the conditions of the Ryazan region. The objects of research are guy-brides VA-306, Samanta, Poseidon 625 variety. It was revealed that the use of mineral fertilizers in sunflower crops at a dose of N120P60K60 contributes to an increase in the basic biometric indicators of plants, which, in turn, has a positive effect on the yield of oilseeds. On average, over the years of research, 2.4-3.1 tons of oilseeds were obtained from 1 hectare. The highest productivity was observed in variants with the Poseidon 625 variety. Keywords: SUNFLOWER, DARK GRAY FOREST SOIL, MINERAL NUTRITION LEVEL, YIELD, OIL CONTENT
Organic matter of soils and technogenic surface formations of residential areas of the city of Perm
Authors: Moskvina Natalia , Shestakov Igor , Mitrakova Natalia
Published: November 2021

On the territory of the left-bank part of Perm, the urban pedocomplexes (UPC) were distinguished as a combination of soil and technogenic surface formations on the same soil-forming rocks within a certain functional zone. Within the UPC, formed on eluvial-deluvial loams and clays in the zone of multi-storey buildings, the surface horizons of soils and TSF (technogenic surface formations) were studied. A change in the zonal trend of humus formation in reclaimed soils was observed as an increase in the content of organic matter, as well as in a change in the type of humus to the humate side. The conservation of zonal features of humus formation in non-purposefully recultivated urban soils and TSF was noted. It manifests in a low or medium content of organic carbon, the formation of a humate-fulvate type of humus. Keywords: URBAN ECOLOGY, URBAN SOILS, URBAN PEDOCOMPLEX, HUMUS, HUMUS TYPE, SOIL PROPERTIES
Vibrational Analysis of a Metallic Column Submitted to Mechanical Axial Load and Fire Exposure
Authors: NDOUKOUO Ahoudou , METSEBO Jules , NJANKOUO J.m
Published: November 2021

Vibrational behavior and structural failure of a metallic beam submitted to simultaneous action of axial load and fire exposure are investigated. Analyses are made at ambient conditions and for two types of fire, ISO 834 fire and parametric fire. Vibrational equation based on heat conduction equation and field equations are constructed and numerically solved to obtain the responses in terms of time histories, bending moment in fire and time to failure against axial load ratio. The heat flux is high enough to affect material properties of the structure and their variation with temperature is taking into account in the mathematical formulation. Results show that heat flux resulting from fire action transforms the buckling problem occurring at room temperature into a bending one. Non-reversible responses and sooner arising of failure are observed for ISO 834 fire even for axial load ratio not able to cause buckling at room temperature. Unlike the case of ISO fire, parametric fire improves reversible deflections within the exposure time and later occurring of failure.
Application Of Appropriate Technology For Automatic Bird Pest Removal And Automatic Fish Feed In The Minapadi System In Beutong Nagan Raya District
Authors: Mahendra Mahendra , Muhammad Arif Nasution  , Fitria Rahmayanti  , Dini Islama
Published: November 2021

The purpose of this research-based service program is to apply the research results of the proposing team's research for community empowerment. The application of the research results was carried out on the program of application of appropriate technology for automatic fish feed and automatic bird repellent on the Minapadi jajar legowo system which is a system of planting rice with fish cultivation in one rice field area simultaneously and the jajar legowo planting system with a spacing of 25 cm . The technology used is automatic feeding and automatic bird repellent. Automatic feeding is done by using a mini water pump that has been modified with the help of a digital timer so that the feed automatically dispenses the feed at the time we specify, which is 3 times a day. The second technology is automatic bird repellent using extracts of herbal ingredients (jengkol) with the help of an automatic sprayer. This technology aims to increase the income of farmers with high productivity of rice yields and increase local fish production. The activity was carried out for 5 months in Beutong Nagan Raya District. The observed results include the feed that comes out of the automatic device as much as 15 gr/second, adjusted for the number and weight of fish. Meanwhile, the air pollution that comes out every 10 minutes is 5 units in a 25m2 plot.
Legal Counseling On Civil Rights Due To Marriage Different Religions In Ogan Ilir Regency – South Sumatra Province
Authors: Junaidi  , Mila Surahmi  , Desmawaty Romli  , Citra Dewi Saputra  , Liza Nofianti
Published: November 2021

Interfaith marriage is a marriage bond between a man and a woman who have different beliefs and religions. In principle, interfaith marriages are prohibited by every religious teaching. Every religious instruction requires a marriage bond to be carried out in a bond of the same faith (one religion). Based on Article 2 paragraph (1) of Law Number 1 of 1974 concerning Marriage, it is explained that a marriage is considered valid if it is carried out according to their respective religions and beliefs. Legal problems arise due to interfaith marriages, including the validity of marriages that give rise to rights and obligations between husband and wife and children's status due to interfaith marriages on their inheritance rights. Interfaith marriages occur in society but are usually covered up. In the case of interfaith marriages in Ogan Ilir Regency, our Community Service Team, Faculty of Law, Sjakhyakirti University conducted legal counseling to understand the legal consequences of interfaith marriages, especially regarding the validity of marriages, child status, and inheritance.
Determining PAUD Teachers’ Capability To Develop Sociable Learning Model Through Traditional Sundanese Games.
Authors: Solihin Ichas Hamid  , Tuti Istianti  , Mohamad Helmi Ismail
Published: November 2021

The application of the Sociable Learning Model has strong relevance as a solution to the problem of early childhood social behavior these days. Meanwhile, the role of Early Childhood Education teachers who have crucial value for Early Childhood cannot be well maximized due to the various restrictions as an effort to handle COVID-19 cases in Indonesia. The implementation of training on the development of the Sociable Learning Model through Traditional Sundanese Games in West Java requires a mapping foundation of the teacher's experiences so that it can provide some meaningful and appropriate resources for further treatments. To accommodate the required data collections, the holding of the workshop is needed to accommodate the variety of teacher's perceptions on the Social Citizenship development efforts in the Early Childhood Education setting that can be a starting point to find out the teacher's basic understanding of the development of social civic behavior in PAUD. The exploration effort is has been carried out by spreading questionnaires to workshop participants to collect various teacher perceptions related to innovations in the development of Social Citizenship Behavioral Skills (PrSKn) based on traditional Sundanese games.

 Keywords: PrSKn, Sundanese traditional games, Teachers' Competency.
Breaking Through Hysteria: Unravelling the Hidden Gender Biases in Healthcare
Authors:   The Madeira School, Gill Karmen
Published: November 2021

A woman comes into the emergency room with chest pain and a heart rate of 220 beats per minute. Her doctor told her it was just an anxiety attack and sent her home with Xanax. But she knew it was more than an episode. After many visits to the doctor, she was diagnosed with endometriosis, a painful disorder where the tissue inside the uterus migrates outside (Billock, 2018).