bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimizing Customer Segments of SMEs by Transforming Business Model Canvas
Authors: Herald Galingga Wira Shenta
Published: October 2023

This research examines the business model canvas in developing customer segments through e-commerce channels for Small and Medium Enterprises (SMEs). SMEs are expected to be sustained by reviewing their business model canvas (BMC) and finding the most potential block of BMC to be developed so that the SMEs could keep contributing to the growth of the Gross Domestic Product. However, not all SMEs have qualified managerial and technical skills to determine their potential. The BMC analysis helps SMEs to unlock their potential value.

This study uses a qualitative approach by assisting one of the SMEs from Jakarta, Indonesia. The tools used to analyze are; Business Model Canvas, Porter's Five Forces, VRIO analysis, and SWOT analysis

The results of the new mapping of the business model canvas by updating certain parts of the business model canvas impact increasing market access for SMEs. They can open a new paradigm for increasing SME market access, which can be done by changing one of the components of the business model canvas.
Analysis on Chinese Ming Pibian Forms, Techniques and Social Functions
Authors: Hao Jixu , Niu Li
Published: October 2023

The pibian (皮弁, pronounced as pì biàn in Chinese) is a kind of cap specific to China. Before the Ming dynasty (1368-1644), it was made of deer hide, while in the Ming dynasty, it was woven with bamboo filament. Through analysis on the forms, techniques and materials used in the pibian preserved, we discovered that pibian displayed a superb artisanship level. The sign of status was depicted through the pibian’s structures and ornaments in an ingenious way, and its structures and components were closely linked with the social culture.
POTENCIAL TERAPÊUTICO DOS CANABINOIDES NA ANSIEDADE E DEPRESSÃO: UMA REVISÃO INTEGRATIVA DA LITERATURA
Authors: De Sousa Jiliélisson Oliveira , Vieira Vitor Barbosa , Da Silva Gabriel Ferreira , Da Silveira Rodrigo Euripedes , Dos Santos Carlos Alberto Feitosa , Lima Luiz Felipe de Oliveira , Bohnenberger Gustavo , Camacho Beatriz Angieuski , Paiva Odilene Ribeiro , Massa João Victor Bezerra , Campiol Neslayne Louise , Maslinkiewicz Alexandre
Published: October 2023

Introdução: Os transtornos psiquiátricos, principalmente ansiedade e depressão, são queixas muito prevalentes na população mundial. Atualmente, esse fato move a comunidade científica a realizar estudos para avaliar alternativas que possam contribuir no tratamento dessas doenças. Por isso, a Cannabis Medicinal (CM) vem ganhando espaço na sociedade e parece ser uma opção terapêutica viável e vantajosa. Objetivo: Evidenciar os possíveis usos terapêuticos dos componentes presentes na planta Cannabis no manejo da ansiedade e depressão. Métodos: Trata-se de uma revisão bibliográfica integrativa, elaborada a partir de trabalhos científicos acerca da ação da Cannabis Medicinal como uma alternativa para o tratamento da ansiedade e depressão. Foram considerados artigos originais e completos publicados em português, espanhol e inglês nos últimos dez anos, de 2013 até 2023, obtidos nas plataformas SCIELO, PUBMED e LILACS. Resultados: As substâncias presentes na planta Cannabis, principalmente o Canabidiol (CBD), parecem ser uma opção promissora e potencialmente benéfica, especialmente para os casos que não respondem aos tratamentos convencionais. Conclusão: A partir dos estudos analisados, evidencia-se que os estudos atuais disponíveis sobre a eficácia dos canabinoides no tratamento dos transtornos mentais são de qualidade variável. Sendo assim, apesar da CM ser uma possível opção para o tratamento de transtornos mentais, ainda se faz necessária a realização de mais pesquisas para elucidar plenamente como funcionaria sua utilização na prática clínica.
USO DA CLASSIFICAÇÃO DE ROBSON PARA AVALIAÇÃO DAS TAXAS DE CESÁREAS EM HOSPITAIS PARANAENSES VINCULADOS AO SISTEMA ÚNICO DE SAÚDE
Authors: Frez Flávia Cristina Vieira , De Oliveira Vitória Goularte , Zulin Aline , Vieira Viviane Cazetta de Lima , Back Ivi Ribeiro , Nogueira Iara Sescon , Lima Ana Luísa Serrano , Sanguino Gabriel Zanin
Published: October 2023

Introdução: Os índices de parto cesariano vêm aumentando mundialmente e ultrapassando, em muitos locais, os índices de parto vaginal. No entanto, tais índices nem sempre refletem a indicação real do procedimento. Objetivo: analisar as taxas de cesáreas de hospitais vinculados à Secretaria Municipal do Estado do Paraná no ano de 2021, exceto universitários, através da Classificação de Robson. Métodos: Trata-se de um estudo descritivo, transversal e de abordagem quantitativa, foram avaliadas 356 instituições de saúde do estado do Paraná, os dados foram coletados no site do Departamento de Informática do Sistema Único de Saúde (DATASUS), através do Sistema de Informações sobre Nascidos Vivos (SINASC) via tabulador oficial do Ministério da Saúde- Tabwim, no ano de 2021. Resultados: Os maiores índices segundo Classificação de Robson, foram de mulheres entre 20 à 34 anos, com companheiro, escolaridade de oito anos ou mais de estudo, multíparas com filhos vivos anteriores a última gestação, sendo estas a termo, com gravidez única e sem anomalias congênitas, além da realização de sete consultas de pré-natal com seu início no primeiro trimestre de gestação. Conclusão: o parto cesariano ultrapassa os índices do parto vaginal. Podemos evidenciar a importância que os profissionais de saúde possuem para revertermos essa realidade através da educação em saúde, e no desenvolvimento de estratégias que minimizem esses números expressivos de cesarianas.
DENTIFRÍCIO DE ALTA CONCENTRAÇÃO DE FLUORETO NO CONTROLE DA DOENÇA CÁRIE: UMA REVISÃO INTEGRATIVA
Authors: Vieira Ana Gabriela de Souza , Guimarães Ana Rita Duarte
Published: October 2023

INTRODUÇÃO: A cárie dentária é uma doença de caráter multifatorial, infecciosa, dieta dependente e resultado de um processo crônico, sendo considerada um problema de saúde pública. Os dentifrícios de alta concentração de flúor (5.000ppm), vem sendo recomendados para pacientes com alto risco de desenvolvimento da doença. OBJETIVO: Verificar o nível de evidência científica encontrada na literatura que indique o papel dos dentifrícios de alta concentração no controle da doença cárie, assim como, analisar em qual população seu uso é indicado e a presença de possíveis efeitos adversos. METODOLOGIA: Trata-se de uma revisão integrativa da literatura, com busca feita nas bases de dados PubMed e Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), utilizando a seguinte combinação: “dentifrices” “AND” “high fluoride” “AND” “dental caries”. RESULTADOS: Foram identificados 381 estudos, os quais foram atribuídos aos critérios de inclusão e exclusão, totalizando um total de 09 artigos que compuseram este estudo após a análise. CONCLUSÃO: Foi possível perceber um elevado nível de evidência científica, apesar da falta de padronização de estratégias metodológicas. Foi observado, a ausência de efeitos adversos relatados e uma importante contribuição do dentifrício de alta concentração para controle da doença cárie, sobretudo em pacientes adolescentes, idosos, irradiados e com alto risco de desenvolvimento da doença.
Tentativa de suicídio em indígenas no estado do Amazonas, Brasil
Authors: Pereira Rodrigo da Silva , Pereira Messias Zaguri , Rodrigues Maura Lucrecia Lavor , Lira Maylline Evelly Freitas , Silva Jorleilson Ferreira da , Angulo Erlinda Clayza Pontes , Lima Paula Andreza Viana , Gama Abel Santiago Muri
Published: October 2023

Objetivo: Analisar o perfil epidemiológico das tentativas de suicídio em indígenas no Estado do Amazonas – Brasil, entre 2017 a 2021. Métodos: Estudo descritivo, com o intuito de analisar o perfil epidemiológico das tentativas de suicídio em indígenas no Estado do Amazonas, entre 2017 a 2021. Os dados foram coletados no SINAN do Ministério da Saúde. Variáveis utilizadas: sexo, orientação sexual, raça/cor, faixa etária, escolaridade, estado civil, local de ocorrência, município de ocorrência, motivo da violência, meio utilizado, se houveram outras tentativas e distribuição mensal/anual. Os dados foram analisados por estatística descritiva, usando cálculo de frequência absoluta e relativa. Resultados: A taxa de incidência anual de tentativa de suicídio variou entre 21,4 a 42,0 casos a cada 100 mil indígenas. A maioria dos casos persistiu no sexo masculino, heterossexuais, idade entre 11 a 20 anos, ensino médio incompleto e solteiros. O enforcamento persistiu como principal meio. Tabatinga concentrou o maior número de ocorrência, o mês de julho reteve a maioria das notificações de tentativas de suicídio. Conclusão: Ratifica-se a necessidade de mais estudos por localidade/etnia a fim de evitar a generalização de dados com o intuito de melhor caracterizar o fenômeno da tentativa de suicídio entre os povos indígenas.
Derangement of metabolic homeostasis, detoxifying ability and CA 15-3 in young adult female rats by fructose (15%) drinking is akin to known carcinogens: A missed fiend?
Authors: Kaur Arshvir , Prasad Chandra Prakash , Mathur Sandeep , Mathur Rajani
Published: October 2023

Objectives:

Breast cancer (BC) has been the bane of peri-and post-menopausal women, but is now increasingly incident in adolescent/young adult (AYA) females. Pari-passu, there has been a >1000% increase in consumption of fructose as a caloric sweetener in soft drinks, whose top consumers are AYAs. The link between fructose consumption and mammary gland (MG) carcinogenesis is not well-established and the same is investigated and compared against known carcinogens such as 7,12-dimethylbenz(a)anthracene (DMBA) and electromagnetic radiations from mobile phone (EMF-MP).

Materials and Methods:

Weaned female Wistar rats were randomly grouped as normal control (NOR), fructose control (FRC), DMBA control (DMC), and exposure control (EXC). For 8 weeks, the NOR was provided chow and water, ad libitum, while FRC, DMC, and EXC additionally received 15% fructose drinking solution, ad libitum, DMBA (20 mg/Kg, p.o; at weaning) and EMF-MP (Global System for Mobile Communications [GSM]), 2 h/day daily), respectively. At the end of the study, the groups were compared for the biomarkers of insulin resistance (IR), carbohydrate and lipid metabolism, liver function, cardiometabolic function, oxidative stress, and MG carcinogenesis.

Results:

The serum markers of MG carcinogenesis (CA 15–3), IR (homeostasis model assessment-IR, area under the curve – oral glucose tolerance test), and liver and cardiometabolic function (serum glutamicoxaloacetic transaminase and homocysteine) were significantly raised (P < 0.05) in FRC versus NOR. The metabolic homeostasis (leptin, ghrelin, triglyceride-Glucose index, glucose-6-phosphatase, triglyceride, high-density lipoprotein, serum glutamic pyruvic transaminase, alkaline phosphatase, and glycogen) and detoxifying ability (free-radical scavenging activity [%] and superoxide dismutase) in FRC were not different from DMC, or EXC.

Conclusion:

The development of early indicators of MG carcinogenesis due to unhindered fructose drinking by AYA female rats is akin to exposure to DMBA or EMF-MPs that evidence the propensity of the former.
Effect of purified Shilajit (Asphaltum punjabianum) on oxidative stress, arterial stiffness and endothelial function in elderly with hypertension: A randomised controlled study
Authors: Patil Satish G. , Patil Kasturi A. , Sarashetti Revanasiddappa , Hadimur Kashinath
Published: October 2023

Objectives:

Growing evidence showed involvement of vascular oxidative stress in the development of endothelial dysfunction, arterial stiffness and hypertension. Many clinical trials of antioxidants have proven unsuccessful in prevention of atherosclerosis and cardiovascular events. There is a need of new therapies that reduce age- and hypertension associated arterial stiffness in elderly individuals. We aimed to determine if shilajit (Asphaltum punjabianum), a natural phytocomplex which is immunomodulator, anti-inflammatory, antioxidant and antiaging, can reduce oxidative stress and improve arterial function in the elderly with hypertension.

Materials and Methods:

A parallel arm, open-label randomised controlled study was conducted on 60 elderly patients with hypertension. Study-group participants received shilajit (500 mg-twice/day for 30 days) with antihypertensives while control-group participants received only antihypertensive therapy. Oxidative stress, arterial stiffness and endothelial function markers were assessed at baseline and after 30 days of treatment.

Results:

Between-group analysis showed a significant decrease in oxidative stress markers: Malondialdehyde (P < 0.001) and oxidised-low-density lipoproteins (P = 0.015); and increase in total antioxidant capacity (P = 0.002), superoxide dismutase (P < 0.001) and reduced glutathione (P < 0.001) with complementary therapy of shilajit. There was no change in the markers of arterial stiffness and endothelial function.

Conclusion:

These findings suggest that shilajit may be of value as a natural antioxidant to reduce oxidative stress in elderly hypertension patients.
A toddler with testosterone: where did it come from?
Authors: Mehta Amrita Rajiv , Rao Sudha Chandrashekhar , Joshi Rajesh , Patil Ajinkya
Published: October 2023

Precocious development of secondary sexual characters not involving pulsatile gonadotropin secretion is known as gonadotropin independent precocious puberty or peripheral precocious puberty (PPP). This form of sexual precocity in males can occur due to gonadal, adrenal, or other testosterone secreting tumors (teratomas, hepatomas, and choriocarcinomas), untreated congenital adrenal hyperplasia, testotoxicosis, and familial male limited precocious puberty. We report a case of a 2-year-old boy with PPP caused due to hepatoblastoma. Complete surgical resection of the tumor was done, and the child received cisplatin chemotherapy.
Cleaning is also caring – Dignity of the child even after death
Authors: D’souza Keith Peter , Karegar Anuradha Fakirappa , Dinand Veronique
Published: October 2023

Bai Jerbai Wadia Hospital for Children in Mumbai is known for its specialized care for children. Its Pediatric Palliative and Supportive Care Unit works toward improving the quality of life for seriously ill children and enhances end-of-life care. This article focuses on the important role of “Maushis” (cleaning staff) in ensuring dignity for deceased children and supporting families at the hospital. Two workshops with “Maushis” led to positive changes in their practices, including attention to detail, cultural sensitivity, and the introduction of a comfortable trolley for transporting deceased children. This initiative promotes respect and dignity for non-medical staff, enhancing the overall care experience in the hospital.
Transabdominal cerclage: The journey of turning bad into good
Authors: Pawar Amol , Shrivastava Sweta , Kadrekar Aishwarya
Published: October 2023

Recurrent pregnancy loss is a challenging obstetric condition that requires thorough evaluation and vigilant antenatal care. Cervical insufficiency is a well-recognized cause of late miscarriage. Here, we are reporting a case of multiple pregnancy failures including both 1st- and 2nd-trimester losses with cervical insufficiency after ruling out all other probable causes. The patient had a history of 3 failed transvaginal cervical cerclage procedures, and hence, in her 7th pregnancy, transabdominal cervical cerclage was attempted that resulted in salvaging the pregnancy beyond viability and the patient delivered a healthy baby through an emergency cesarean section near term. The patient was reconceived with the transabdominal cerclage in situ and delivered with a successful fetal and maternal outcome despite having multiple high-risk factors. This highlights the effectiveness of transabdominal cervical cerclage to prevent spontaneous mid-trimester loss and preterm delivery when previous transvaginal cerclage has failed.
THE ORIGINS AND PREREQUISITES OF FORMATION OF AVANT-GARDE ART: AESTHETIC AND PHILOSOPHICAL ANALYSIS
Authors: Shevchuk Kateryna
Published: October 2023

The article is devoted to analyzing the formation and appearance of modern avant-garde art. The author focuses on the study of the main prerequisites for the emergence of the avant-garde while paying attention to the coverage of transformations in the socio-economic and cultural sphere from the end of the 19th century, which impacted the changes in the artistic creativity of that time. The article analyzes the ontological and existential aspects of the formation of works of modern art. Also, it characterizes the socio-cultural background of transformations in the field of artistic practice in the 19th and early 20th centuries. The author draws attention to the change of the main components of a work of modern art in comparison with a work of classical art at the structural, value, and experiential levels. In connection with the growing attention to novelty, creativity and originality in modern times, the article considers the connection between novelty and tradition in modern art, outlines the role of tradition in general in the formation of artistic creativity of the studied period, as well as the attitude towards tradition inherent in avant-garde artists: revision of traditional concepts and categories, criticism and opposition to tradition. The tendency of the synthesis of various types of art, the convergence of various types of art, and the combination of plastic arts with music, sculpture, and audiovisual art, the use of various installations, interactive technologies, characteristic of modern creativity, is highlighted. It was revealed that as a result of the transformation of the aesthetic object in modern artistic creativity, there was a rethinking of the meaning of the concept of "aesthetic object", which caused transformations in the field of aesthetic experience, and, therefore, an important aspect of the research was the analysis of the possibility of aesthetic experience and aesthetic evaluation of works of modern art. In addition, the problem of the correspondence of the foundations of traditional aesthetic thought to the latest artistic challenges and the ability of aesthetic theory to respond to challenges in the field of modern artistic practice is highlighted.
PHILOSOPHICAL PARADIGM OF SCIENCE EDUCATION: CONCEPTUAL EXPLANATION
Authors: Matusevych Tеtiana
Published: October 2023

The relevance of the development of science education provokes new discussions about its philosophical foundations, which cover the attributes of progress in this field since antiquity and offer new projects and perspectives for the development of a philosophical paradigm of science education in view of the challenges and requirements of today. The article is devoted to the analysis of three main approaches to define the philosophical paradigm of science education: interiorization, interrelational, and multiperspective. The interiorization approach to defining the philosophical paradigm of science education involves the development of the "philosophy of science education" as an "internal philosophy". The interrelational approach to delineating the philosophical paradigm of science education is based on identifying the relationship between the philosophy of science and science education, the relationships between sections of philosophy and scientific inquiry. The most comprehensive approach to defining the philosophical paradigm of science education is multi-perspective, which is based on addressing various philosophical trends and their understanding of scientific meaning and rationality, mutual influences and contradictions, determining the contribution of each of them to the progress of the theory and practice of science education. This approach usually develops the concept of science education through the prism of such philosophical trends as John Dewey's pragmatism, constructivism, rationalist school, classical empiricism, and postmodernism. Each of the mentioned directions is analyzed in the article in the context of the dialectics of science education.
КЛИНИЧЕСКАЯ КАРТИНА ТЯЖЕЛОЙ АНЕМИИ У ДЕТЕЙ С ЦЕЛИАКИЕЙ
Authors: Аргунова Е. Ф. , Протопопова Н. Н. , Кондратьева С. А. , Ядреева О. В. , Николаева С. А. , Лукашевич А. С.
Published: October 2023

Целиакия – иммуноопосредованное системное заболевание, которое возникает в ответ на употребление глютена или соответствующих проламинов генетически предрасположенными индивидуумами и характеризуется наличием широкой комбинации глютен-зависимых клинических проявлений. Средняя мировая частота выявления специфичных для целиакии антител составляет 1,4%, при этом у 0,7% населения мира заболевание подтверждено гистологически. Распространенность болезни значительно выше у детей, чем у взрослых.

В статье описаны случаи развития железодефицитной и В12-дефицитной анемии тяжелой степени у двоих детей: девочки 3 лет и мальчика 14 лет. Дети значительно отставали в физическом развитии, у обоих был выраженный дефицит массы тела (SDS веса ниже -2,5). Девочка была низкорослая (SDS роста -3,39), с худыми конечностями и большим животом. При обследовании выявлена микроцитарная гипохромная анемия тяжелой степени (гемоглобин 66 г/л, MCV 57,0 фл, МСН 15,1 пг, МСНС 26,5 г/дл, RDW-CV 23,4%), снижение уровня сывороточного железа и ферритина. У мальчика была макроцитарная гиперхромная анемия тяжелой степени (гемоглобин 44 г/л, MCV 110,6 фл, МСН 38,9 пг, МСНС 35, г/дл, RDWCV 18,1%), низкая активность витамина В12 в сыворотке крови. Для выяснения причины анемии обеим детям проведена эзофагогастродуоденоскопия со взятием биопсии из постбульбарного отдела двенадцатиперстной кишки. Морфологическая картина соответствовала целиакии, Marsh II. У девочки были выявлены повышенные титры антител к эндомизию Ig A, Ig G, к диамидированным пептидам глиадина класса Ig G, Ig А. Причиной развития тяжелой анемии у детей явился синдром мальабсорбции, обусловленный целиакией. Данный диагноз установлен впервые. Дети консультированы гастроэнтерологом, рекомендована строгая аглютеновая диета. При опросе матери девочки и опекуна мальчика по телефону через 4 и 3 месяца соответственно от даты выписки из стационара выяснилось, что дети не соблюдают назначенную диету. Это можно объяснить поздней постановкой диагноза, недостаточной осведомленностью родителей (опекунов) о целиакии и ее последствиях.
КЛИНИЧЕСКАЯ ХАРАКТЕРИСТИКА ЭФФЕКТИВНОСТИ ПРИМЕНЕНИЯ МИНИВИНТОВ ПРИ ЛЕЧЕНИИ САГИТТАЛЬНЫХ АНОМАЛИЙ ПРИКУСА
Authors: Антонова А. А. , Син Хе О , Сухоловская О. А.
Published: October 2023

Зубочелюстные аномалии характеризуются высокой распространенностью и занимают третье место после кариеса зубов и болезней пародонта, где более 82 % населения имеют нарушения зубочелюстной системы, варьирующие от легких косметических дефектов и незначительных отклонений до серьезной патологии, вызывающей нарушение функциональной жизнедеятельности. В связи с этим исследования, направленные на совершенствования ортодонтического лечения зубочелюстных аномалий, являются актуальными.

Цель. Провести клиническую оценку эффективности использования миниимплантатов в ортодонтической практике при лечении сагиттальных аномалий прикуса.

Методы исследования. Проведена оценка эффективности лечения у 50 пациентов, которые разделены на 2 группы. В контрольной группе (20 человек) – пациенты с зубочелюстными аномалиями, лечащиеся стандартной техникой прямой дуги на раскрывающих пружинах, в опытной группе (30 человек) применялись минивинты. Анализировались сроки лечения в месяцах, эффективность установки минивинтов в различных анатомических зонах, толщина кортикальной пластики.

Результаты. При использовании минивинтов на верхней челюсти на 4 месяц наблюдается корпусная дистализация боковой группы зубов, при этом клыки улучшают свое положение по I классу, в свою очередь, при работе на раскрывающих пружинах происходило ангуляционное смещение за счет наклона коронковой части зуба дистально, что оказывало не высокую эффективность в дистализации. Срок лечения ортодонтической патологии при использовании минивинтов составляет 19 – 27 месяцев, тогда как при работе на раскрывающих пружинах и эластических тягах 26 – 33 месяца. Использование минивинтов ускоряет передвижение боковой группы на верхней и нижней челюсти. Подтверждена эффективность использования микроимплантатов в дистализации, где выявлена сильная связь между признаками. Оптимальным местом для установки миниимплантата является плотная прикрепленная десна (ниже уровня переходной складки на ~5мм). Трудности с позиционированием микроимплантов на верхней челюсти связаны с низким расположением дна верхнечелюстного синуса. Наблюдается более тонкая кортикальная пластинка в дистальных отделах верхней челюсти, что не позволяет добиться адекватной первичной стабильности микроимпланта.

Выводы. Практическое применении минивинтов обуславливает значительное сокращение срока лечения сагиттальных аномалий прикуса, где необходимо учитывать тип биотопа слизистой оболочки и толщины кортикальной пластинки на процесс интеграции микроимпланта.
ВЛИЯНИЕ ХРОНИЧЕСКОЙ ГИПОКСИИ РАЗЛИЧНОГО ГЕНЕЗА НА МОРФОМЕТРИЧЕСКИЕ ПОКАЗАТЕЛИ СЕЛЕЗЕНКИ ЛАБОРАТОРНЫХ ЖИВОТНЫХ
Authors: Наумов А. В. , Никитюк Д. Б. , Наумова Л. И. , Шишкина Т. А. , Давлатова И. С.
Published: October 2023

Селезенка представлена двумя компартментами с разными клеточными элементами, отличающимися по иммунофенотипу, происхождению и функциям. Это предопределяет не только разную чувствительность и отличие в реактивности на внешние раздражающие факторы, но и зависящие от длительности и типа действующего раздражителя специфические изменения внутри компартмента как в норме, так и при патологии. Целью исследования стало сравнительное изучение морфометрических параметров структур селезенки на фоне изолированной гипоксической гипоксии и гипоксии, сочетанной с ингаляцией природного газа. Эксперимент проведен на 113 белых беспородных самцах крыс с использованием затравочных камер института им. Ф.Ф. Эрисмана с подачей контролируемого состава воздушногазовой смеси. Началом эксперимента считалось снижение концентрации кислорода до 17,5%. Животные помещались в условия обедненной кислородной смеси в течение пяти дней в неделю четыре часа в день до достижения концентрации кислорода 13,5 – 14%. Эксперимент длился 120 суток, выведение животных осуществлялось кратностью раз в месяц – через 30, 60, 90 и 120 суток. Смешанная гипоксия моделировалась с использованием тех же затравочных камер, дополнительно к обедненной воздушной смеси добавлялся через штуцер природный газ Астраханского месторождения в концентрации 3 мг/м³. Была выделена контрольная группа (n=13), которую помещали в камеру в аналогичном временном режиме, но с обычным составом воздуха. Для изготовления гистологических препаратов из брюшной полости извлекалась селезенка. Препараты окрашивались гематоксилином-эозином и по Ван-Гизон. Анализ и визуализацию препаратов проводили с использованием светового микроскопа ZeissAxioScopeA1 (Германия) и цифрового сканера микропрепаратов LeicaAperioCS2. Обнаружено, что к 120 суткам эксперимента в обеих экспериментальных группах происходят изменения со стороны капсулы – утолщение и разволокнение с явлениями отека, аналогичные изменения происходят со стороны трабекул – утолщение за счет явлений коллагенообразования и отека. Со стороны компартментов селезенки в группе животных с изолированной гипоксической гипоксией отмечается нарастание общего объема белой пульпы к концу 90 суток эксперимента, что связано с увеличением размера структурных компонентов белой пульпы. Но к 120 суткам происходит уменьшение объема белой пульпы по сравнению с предыдущим сроком и контролем. В группе животных со смешанной гипоксией сочетание факторов гипоксического и токсического воздействия природного газа вызвало изменения в распределении объемных долей структурных зон селезенки на более ранних сроках. Так, сокращение объема и плотности распределения клеточных элементов лимфоидных узелках происходит уже к 90 суткам эксперимента, при этом наблюдается исчезновение герминативных центров в ряде лимфоидных узелков, то есть срыв адаптивных возможностей наступает уже после 60 суток эксперимента.
Activities of Regional Branches of the Artists’ Union of Russia in the Process of Forming the Art Space of Modern Russia
Authors: Zhiwei Ding
Published: October 2023

The purpose of this article is to consider the role of regional branches of the largest creative association in Russia, the Artists’ Union of Russia, in the cultural life of cities. These structures, being part of a large organisation that has its own traditions, build original forms of interaction with the cultural space of cities and regions, and also provide artists with access beyond its borders. Membership in these associations provides many opportunities for provincial artists, as they are focused on their support and promotion. Their activities are aimed at preserving existing artistic and institutional traditions and, at the same time, actively participating in modern art processes.
The Past and Future of Musical Genre in the Violin Concerto by Jean Sibelius
Authors: Konnov Vladimir P.
Published: October 2023

The purpose of this investigation is to analyse the Violin Concerto, Op. 47 by Jean Sibelius within the context of the composer’s symphony legacy as a whole. Among lots of historical connotations, it was the late romantic symphony conception of Anton Bruckner and J. S. Bach’s polyphony that were pointed out as factors that most infl uenced the conception and structure of Sibelius’s work. The violin concertos by J. Sibelius and D. Shostakovich were put together to trace the prospects for the development of the genre from the beginning to the middle of the 20th century.
Analysis of Folklore Note Sources as a Method for Transforming the Modern Performance of Cossack Songs
Authors: Mironova Anastasia V.
Published: October 2023

The purpose of the article is to analyse the signifi cant aspects of folklore note sources that reveal their musical and semantic essence to performers of Cossack songs. Features of the singing and performing modifi cation of vocal works are associated with the modern performing interpretation of Cossack folk songs. In the present, singers highlight the deep content of the original source, plunging into the methodological problem of musicological analysis. To popularise the vocal material, performers add personal interpretation of the Kuban Cossack songs, using the processed, adapted musical resources of the folk epic.
The Repertoire of S. T. Richter: Touches to the Creative Portrait
Authors: Chang Liu
Published: October 2023

The prominent musician-performer of the 20th century, Russian pianist Svyatoslav Teofi lovich Richter reached the tops of piano mastery thanks to virtuoso technique, expressive intonation, impeccable sense of style, depth of interpretation and extensive repertoire. The choice of works was due to the personal preferences of the pianist, the depth of the content of opuses, and the desire to bring aesthetic pleasure to the public with the beauty of music. The purpose of the work was to identify the principles of Richter’s selection of a concert repertoire based on an analysis of his statements about composers, aesthetic preferences, a list of works, concert programmes and sound recordings. Richter seeks to perform works of deep content, in which important ideas for all mankind are embodied, passionate temperament and exciting emotions are conveyed. A warm response in Richter’s performing arts was found by compositions combining the sincerity of utterance and the simplicity of images in the spirit of the revelations of romantic composers.
PERMINTAAN KONSUMEN TERHADAP WISATA MANGROVE SETAPUK DI KELURAHAN SETAPUK BESAR KOTA SINGKAWANG
Authors: Muin Sudirman , Widhanarto Ganjar Oki , Andryani Vivi
Published: October 2023

The mangrove forest as an ecosystem system in coastal areas has the potential for natural beauty and the environment in the form of constituent components consisting of vegetation, biota or association organisms, wildlife and the surrounding environment (Purwanto, 2013). The research objective is to analyze consumer demand for mangrove tourism in Surya Perdana Mandiri, Setapuk Besar Village, Singkawang City, and to analyze the influence of the main factors of attraction, supporting factors of attraction, travel costs, travel time and length of visit on consumer demand for mangrove tourism Surya Perdana Mandiri (SPM). The research sample came from SPM mangrove tourism visitors, and the sample was taken using purposive accidental sampling method with a total sample of 70 respondents. The results showed that consumer demand for the Setapuk Mangrove Tourism object is quite high, this is evident that 38.57 percent of respondents in the past one year period have visited the Setapuk mangrove tourism object more than 4 times. The main factor of attraction (X1) has a significant positive effect, the supporting factors of attraction (X2) have a positive and insignificant effect, travel costs (X3) have a negative and insignificant effect, travel time (X4) has a negative and insignificant effect, and (5) Length of visit (X5) has no significant positive effect on consumer demand for mangrove tourism object.Keywords: Consumer demand, mangrove tourism, Setapuk Besar Village. AbstrakHutan mangrove sebagai suatu sistem ekosistem di wilayah pesisir memiliki potensi keindahan alam dan lingkungan berupa komponen penyusun yang terdiri dari vegetasi, biota atau organisme asosiasi, satwa liar dan lingkungan sekitarnya (Purwanto, 2013). Penelitian ini bertujuan untuk menganalisis permintaan konsumen terhadap wisata mangrove di Surya Perdana Mandiri, Desa Setapuk Besar, Kota Singkawang, dan menganalisis pengaruh faktor utama daya tarik, faktor pendukung daya tarik, biaya perjalanan, waktu tempuh dan lama kunjungan pada permintaan konsumen terhadap wisata mangrove Surya Perdana Mandiri (SPM). Sampel penelitian berasal dari pengunjung wisata mangrove SPM, dan sampel diambil dengan metode purposive accidental sampling dengan jumlah sampel 70 responden. Hasil penelitian menunjukkan bahwa permintaan konsumen terhadap objek Wisata Mangrove Setapuk cukup tinggi, hal ini terbukti 38,57 persen responden dalam kurun waktu satu tahun terakhir telah mengunjungi objek wisata mangrove Setapuk lebih dari 4 kali. Faktor utama daya tarik (X1) berpengaruh positif signifikan, faktor pendukung daya tarik (X2) berpengaruh positif dan tidak signifikan, biaya perjalanan (X3) berpengaruh negatif dan tidak signifikan, waktu tempuh (X4) berpengaruh negatif dan tidak signifikan. berpengaruh tidak signifikan, dan (5) Lama kunjungan ( X5) berpengaruh positif tidak signifikan terhadap permintaan konsumen terhadap objek wisata mangrove.Kata kunci: Permintaan konsumen, wisata mangrove, Kelurahan Setapuk Besar.
KEANEKARAGAMAN JENIS SERANGGA DETRITIVOR DI DESA PAMPANG HARAPAN TAMAN NASIONAL GUNUNG PALUNG (Diversity of Detritivor Insect Species in Pampang Harapan Village, Gunung Palung National Park)
Authors: Darwati Herlina , Kamalramadan Catur Aditia , Rifanjani Slamet
Published: October 2023

The diversity of insect detritivores can be done by several methods, including pitfall traps and barlese funnels. This study aims to obtain and compare data on the variety and abundance of ground surface insects as detritivores in two different forest types. The research was conducted in Pampang Harapan Village, Gunung Palung National Park Area, for ± two months. To get data on the diversity of insect detritivores found, insects will group them based on their role. The data obtained is analyzed and receives a value of 1.6, which is moderate diversity for both forest types. Then, compare the abundance data using species similarity analysis and get a value of 69.565%, which shows the importance of species similarity in both forest types has high species similarity. Then use the T-test to get the difference in the two forest types and get a T count value of 1.644, which is smaller than the t table of degrees of freedom 9; confidence 0.025% is worth 2.262 (t-count < t-table), proves that there is no significant difference between detritivores in lowland forests and detritivores in coastal forests Keywords: Abundance, Detritivor, Species similarityAbstrakKeanekaragaman jenis serangga detritivor dapat dilakukan dengan beberapa metode di antaranya pitfall trap dan corong barlese. Penelitian bertujuan mendapatkan dan membandingkan data keanekaragaman dan kelimpahan jenis serangga permukaan tanah sebagai detritivor pada dua tipe hutan dataran rendah dan hutan pantai. Penelitian dilaksanakan di Desa Pampang Harapan Kawasan Taman Nasional Gunung Palung selama ±2 bulan. data keanekaragaman jenis serangga detritivor serangga yang ditemukan dikelompokkan berdasarkan perannya dengan nilai 1,6 yaitu keanekaragaman sedang untuk kedua tipe hutan. Nilai kesamaan jenis 96.565% yang menunjukkan nilai kesamaan jenis di kedua tipe hutan memiliki kesamaan jenis yang tinggi. T hitung 1,644 yang lebih kecil dari t tabel derajat bebas 9, kepercayaan 0,025% bernilai 2,262 (t-hitung < t-tabel) membuktikan bahwa tidak ada perbedaan yang signifikan antara serangga detritivor di hutan dataran rendah dan serangga detritivor di hutan pantaiKata kunci : Detritivor, Gunung Palung, Kelimpahan, Kesamaan
ETNOZOOLOGI MASYARAKAT DAYAK KUBIN DESA MANGGALA KECAMATAN PINOH SELATAN KABUPATEN MELAWI UNTUK RITUAL ADAT DAN MISTIS
Authors: Fathurrahman Muhammad , Yani Ahmad , Ardian Hafiz
Published: October 2023

Indonesia is a country that has many islands and biological natural resources, one of which is on the island of Kalimantan. Kalimantan is famous for the existence of the Dayak tribe, which has a characteristic. The Dayak tribe also has diversity in the use of animals and can not be separated also in society still maintains ancestral values that still held fast since the days of their ancestors. The Dayak tribe uses animal parts for traditional and supernatural purposes. The purpose of this study was to record the types of animals used for traditional and mystical rituals and the meaning of the use of animals in the Dayak Kubin Community, Manggala Village, Pinoh Selatan District, Melawi Regency. This study uses survey methods and direct interviews, selecting respondents with side snowball for data collection with interviews aimed at people who are considered to have knowledge about the use of animals, by getting 17 types of animals that are used for traditional and mystical rituals, there are 4 types of animals that are used for traditional rituals and 19 traditional rituals carried out by using animals and there are 15 types of animals that are believed to be mystical signs by the Dayak Kubin Community, Manggala Village, Pinoh Selatan District, Melawi Regency.Keywords: Dayak Kubin, Etnozoologi, Mystical and Traditional Ritual.AbstrakIndonesia merupakan negara yang memiliki banyak pulau dan memiliki sumber daya alam hayati, salah satunya di pulau Kalimantan. Kalimantan terkenal dengan keberadaan suku Dayak yang memiliki ciri khas. Pada suku Dayak juga memiliki keragaman dalam memanfaatkan hewan dan tidak lepas juga dalam masyarakat masih mempertahankan nilai leluhur yang masih tetap memegang teguh sejak zaman nenek moyang. Suku Dayak memanfaatkan bagian-bagian hewan untuk keperluan adat dan supranatural. Tujuan dari penelitian ini adalah mendata jenis-jenis hewan yang dimanfaatkan untuk ritual adat dan mistis dan makna dari pemanfaatan hewan pada Masyarakat Dayak Kubin Desa Manggala Kecamatan Pinoh Selatan Kabupaten Melawi. Penelitian ini menggunakan metode survei dan wawancara secara langsung, pemilihan responden dengan snowball samping untuk pengumpulan data dengan wawancara ditujukan kepada orang yang dianggap memiliki pengetahuan mengenai pemanfaatan hewan, dengan mendapatkan 17 jenis hewan yang dimanfaatkan untuk ritual adat dan mistis, terdapat 4 jenis hewan yang dimanfaatkan untuk ritual adat dan 19 ritual adat yang dilakukan dengan memanfaatkan hewan serta terdapat 15 jenis hewan yang dipercaya sebagai pertanda mistis oleh masyarakat Dayak Kubin Desa Manggala kecamatan Pinoh Selatan Kabupaten Melawi.Kata kunci: dayak kubin, Etnozoologi, ritual adat dan mistis
IDENTIFIKASI BENTUK KEARIFAN LOKAL DALAM PENGELOLAAN AGROFORESTRI TRADISIONAL DI KABUPATEN NAGEKEO, PROVINSI NUSA TENGGARA TIMUR
Authors: Ule Fransiska - , Dako Fransiskus Xaverius , Benu Yakub - , Kleruk Flora Evalina Ina
Published: October 2023

Mixed gardening is a form of traditional agroforestry whose management is carried out from generation to generation. The people of Jawapogo Village refer to mixed gardens as uma. Uma is a land management system that has been practiced by farmers and developed in the community according to local wisdom. Local wisdom is a custom and habit carried out by a group of people from generation to generation that is still maintained by indigenous peoples in certain areas. This study aimed to find out the form of local wisdom used by the Jawapogo Village community in managing uma. This research was carried out from September to November 2021 in Jawapogo Village, Nagekeo Regency. This data collection method was carried out through in-depth interviews with farmers, who were respondents, and also with traditional leaders using a questionnaire. The data is then presented descriptively using data analysis techniques, which consist of three paths: data reduction, data presentation, and drawing conclusions. Based on the results of the research, traditional agroforestry management in Jawapogo Village, Nagekeo Regency, has several forms of local wisdom, namely: Lera Ie, which usually occurs the day after the funeral of a deceased person, and on that day the community is not allowed to carry out activities on the land; Ti'i Ka Ebu Kajo, which is a gift eaten to the ancestors and done before and after planting; and Voe, which means doing a work in mutual cooperation. and Mendi persembahan Lau Gereja, which means giving offerings to the church.
In-Situ Monitoring of Mechanochemical MOF Formation by NMR Relaxation Time Correlation
Authors: Leger Madeleine , Guo Jiangfeng , MacMillan Bryce , Titi Hatem , Friscic Tomislav , Blight Barry , Balcom Bruce
Published: October 2023

In this paper, we present a new approach to monitoring mechanochemical transformations, based on a magnetic resonance method in which relaxation time correlation maps are used to track the formation of the popular metal-organic framework (MOF) materials Zn-MOF-74 and ZIF-8. The two-dimensional (2D) relaxation correlation measurement employed yields a T1-T2* spectrum which visually and analytically identifies different 1H environments in the sample of interest. The measurement is well-suited to analyzing solid mixtures, and liquids, in complex systems. Application in this work to monitoring MOF formation shows changes in signal amplitudes, and their MR lifetime coordinates, within the 2D plots as the reaction progresses, confirming reaction completion. This new measurement provides a simple way to analyse solid-state reactions without dissolution, and there is a logical pathway to benchtop measurement with a new generation of permanent magnet-based MR instruments. The methodology described permits measurement in an MR compatible milling container, which may be directly transferred from the shaker assembly to the MR magnet for in-situ measurement of the entire reaction mixture.
Calcination Heterogeneity in Li-rich Layered Oxides: a Systematic Study of Li2CO3 Particle Size
Authors: Busse Grace , Csernica Peter , Lim Kipil , Lee Junghwa , Jiang Zhelong , Rivera Diego , Kim Young Jin , Shapiro David , Gent William E. , Chueh William C.
Published: October 2023

Li- and Mn-rich (LMR) layered oxide positive electrode materials exhibit high energy density and have earth abundant compositions relative to conventional Ni-, Mn-, and Co-oxides (NMCs). The lithiation of coprecipitated precursors is a key part of synthesis and offers opportunities for tuning the properties of LMR materials. Whereas the morphology of transition metal precursors has received substantial attention, that of Li sources has not. Using Li1.14Mn0.57Ni0.29O2 as a model system, in this work we establish a detailed understanding of LMR calcination pathways via in situ and ex situ diffraction, spectroscopy, microscopy and thermogravimetry. Our work shows that large Li2CO3 particle size modulates a previously misunderstood thermogravimetric feature present at the Li2CO3 melting point during layered oxide calcination and causes heterogeneity at larger length scales (inter-secondary particle) than previously reported (intra secondary particle). This work highlights the sensitivity of layered oxide calcination pathways to synthesis conditions and suggests design rules to minimize calcination heterogeneity in layered oxides beyond LMR.
MetalDock: an open access docking tool for easy and reproducible docking of metal complexes
Authors: Hakkennes Matthijs , Buda Francesco , Bonnet Sylvestre
Published: October 2023

Despite the proven potential of metal complexes as therapeutics, the lack of computational tools available for high-throughput screening their interaction with proteins is a limiting factor towards clinical developments. To address this challenge, we introduce MetalDock, an easy-to-use, open access docking program for docking metal complexes to proteins. Our tool integrates the AutoDock docking engine with three quantum software packages to automate the docking of metal-organic complexes to proteins. We used a Monte Carlo sampling scheme to obtain the missing Lennard Jones parameters for 12 metal atom types and demonstrated that these parameters generalise exceptionally well. Our results show that the poses obtained by MetalDock are highly accurate as they predict the binding geometries experimentally determined by crystal structures with high spatial reproducibility. Three different case studies are presented which demonstrate the versatility of MetalDock for the docking of diverse metal-organic compounds to different biomacromolecules.
Tailored Functional Monolayers Made from Mesoionic Carbenes
Authors: Maisonhaute Emmanuel , Sadek Omar , Rabah Jad , Mercier Dimitri , Marcus Philippe , Chauvier Clément , Ribot François , Fensterbank Louis
Published: October 2023

Significant progress has been made over the last decades in surface functionalization of coinage metals using thiols and more recently N-heterocyclic carbenes. As shown in this work, mesoionic carbenes (MICs) provide straightforward access to a novel class of surface ligands and thus materials. Importantly, MICs are easily accessed from triazolium salts (TS) onto which functional groups may be attached with little synthetic effort. Here, we present a library of TS that were further converted into MICs, in situ, and grafted to gold surfaces. The modified surfaces were thoroughly characterized by advanced spectroscopic methods and electrochemistry for MICs bearing electroactive moieties. We also prepared mixed MIC/thiol self-assembled monolayers, which opens the route to multifunctional surfaces.
Triazenolysis of Alkenes: Aza-version of Ozonolysis
Authors: Koronatov Aleksandr , Sakharov Pavel , Kaushansky Alexander , Fridman Natalia , Gandelman Mark
Published: October 2023

Numerous applications of alkenes exist due to their abundance and versatility in chemical transformations. In this study, we present a unique and novel chemical transformation of alkenes, the aza-version of canonical ozonolysis reaction, which we termed as triazenolysis. This process offers a non-trivial and previously unfeasible synthetic disconnection, allowing the cleavage of a C=C double bond into two new C-N bonds in a reductive manner. We carefully examined the applicability of the reaction, finding that diverse cyclic alkenes are suitable for the developed process. Furthermore, we present an example of an acyclic alkene, illustrating the potential for expanding triazenolysis to other acyclic counterparts. Through DFT calculations, we explored the mechanism of the key step and demonstrated the significance of Lewis acid catalysis in achieving the desired transformation.