bluuebunny/crossref_metadata_2025 huggingface dataset:
Изменение теплопроводности многослойного массива углеродных нанотрубок при его поперечном сжатии
Authors: Савин А.В.
Published: December 2021

Numerical simulation of thermal conductivity across a multilayer array of single-walled carbon nanotubes is carried out. The effect of transverse compression of the array on thermal conductivity has been studied. It is shown that the compression of the array can occur uniformly when all the nanotubes of the array are compressed equally, and it can occur inhomogeneously when a part of the nanotubes is strongly compressed, and the other part is weakly compressed. With homogeneous compression, the thermal conductivity of the array increases, but with inhomogeneous compression, it does not change and may even decrease in case of a large number of layers. This effect is especially pronounced for arrays of nanotubes of small diameter (D < 2 nm)
YENİ NESİL E-DÖNÜŞÜM SİSTEMLERİ İÇİN ÖLÇEKLENEBİLİR UYGULAMA MİMARİSİ
Authors: ARSLAN Halil , AKAR Şeyma , ŞAHİN Özgür
Published: December 2021

İnternet ve teknolojinin gün geçtikçe gelişmesi günlük hayatta olduğu gibi özel ve kamu sektörünü de etkilemiştir. Özellikle elektronik dönüşüm neticesinde kurum, kuruluş ve vatandaşlar işlemlerini e-devlet ve e-belediye gibi elektronik ortamlardan gerçekleştirmektedir. Bu dönüşümlerden birisi de Çalışma ve Sosyal Güvenlik bakanlığının geliştirdiği iş sağlığı ve güvenliği bilgi yönetimi sistemidir (İBYS). Kurum ve kuruluşlar gerçekleştirilen her iş sağlığı ve güvenliği işlemini İBY sistemine göndermekle yükümlüdürler. Gönderme işlemi de bakanlıkça yetkilendirilmiş entegratör firmaların geliştireceği uygulamalar üzerinden yapılmalıdır. Bu uygulamaların birden fazla kaynaktan aynı anda gelen verileri yönetebilmesi ve kayıpsız şekilde IBYS sunucusuna aktarması gerekir. Çalışmamızda bu ihtiyacın giderilebilmesi için E-Sağlık ismi verilen web uygulaması geliştirilmiştir. Geliştirilen uygulama birçok kaynaktan aynı anda gelen verileri verimli şekilde yöneterek IBYS işlemini gerçekleştirmektedir. Bununla beraber geliştirilen web uygulaması ölçeklendirilebilir olduğu için artan isteklere rahatlıkla cevap verecek şekilde tasarlanmıştır.
GRAVİTE DÜŞEY TÜREV VERİLERİYLE BATI KARADENİZ BÖLGESİNİN YAPI SINIRLARININ ARAŞTIRILMASI
Authors: ELMAS Ali , PARLAK Abdurrahman
Published: December 2021

Bu çalışma ile EGM08 gravite verilerin düşey türev değerlerine toplam yatay türev, eğim açısı ve teta açısı yöntemleri uygulanarak Batı Karadeniz Bölgesi'nin jeolojik birimlerinin sınırlarının temel kaya seviyesinde araştırılması hedeflenmiştir. Bu süreksizlik sınırlarını ortaya çıkarırken, toplam yatay türevin maksimim genlik değerleri, eğim açısının sıfır genlik değerleri ile teta açısı haritasının maksimum genlik değerlerinden yararlanılmıştır. Belirlenen, yoğunluk farkından kaynaklanan sınırlar, çalışma alanının bilinen süreksizlikleri ile kıyaslanmıştır. Bu çalışmadaki sonuçlarla daha önceden yapılmış olan çalışmaların sonuçları arasında alaka olmasının yanı sıra, yeni süreksizlik sınırları tespit edilmiştir. Bunun yanında çalışma alanının yumuşak-sert sediment, temel kaya, Conrad, Moho ve litosfer-astenosfer topoğrafyalarının ortalama derinlikleri genlik spektrumu ile hesaplanmıştır. Bulunan sonuçların daha sonradan yapılacak çalışmalara işık tutacağı düşünülmektedir.
V TİPİ HAVALI BİR GÜNEŞ KOLEKTÖRÜNÜN ISIL PERFORMANSININ DENEYSEL OLARAK İNCELENMESİ VE YAPAY SİNİR AĞLARI İLE MODELLENMESİ
Authors: SAYDAM Doğan Burak , ÇERÇİ Kamil Neyfel , HÜRDOĞAN Ertaç
Published: December 2021

Bu çalışmada, V tipi emici plaka yüzey geometrisine sahip çift geçişli havalı bir güneş kolektörü tasarlanarak imal edilmiş ve kolektörün performansı Osmaniye ili iklim koşullarında deneysel olarak incelenmiştir. Deney düzeneğinde sıcaklık, nem, ışınım ve hava hızı gibi farklı parametreler ölçülmüş ve elde edilen veriler kullanılarak termodinamiğin birinci yasasına göre kolektörün enerji analizi yapılmıştır. Çalışmada ayrıca deneysel olarak elde edilen kolektör çıkış sıcaklığı, üç farklı Yapay Sinir Ağı modeli kullanılarak tahmin edilmiştir. Çalışma sonucunda kolektör giriş ve çıkış sıcaklığı arasında maksimum 36,07°C’lik bir fark olduğu tespit edilmiştir. Isıl verim deney süresince maksimum %71,42 değerine ulaşmış ve ortalama ısıl verim ise %56,21 olarak hesaplanmıştır. Çıkış sıcaklığının tahminlenmesi için oluşturulan her üç model (YSA-1,2,3) için de yakınsamanın çok iyi olduğu fakat LevenbergMarquardt eğitim algoritmasının kullanıldığı YSA-1 modelinin diğer modellere göre deneysel sonuçların tahmininde daha etkili olduğu tespit edilmiştir. Tahminlenen kolektör çıkış sıcaklığı değerleri kullanılarak hesaplanan kolektör ısıl verimi, deneysel verilerle hesaplanan ısıl verim ile uyum içerisindedir.
Manual de producción de semilla sexual de Cratylia argentea cv. Veranera para los Llanos Orientales de Colombia
Authors: Pardo Barbosa Oscar , Flórez Gómez Deisy Lorena , Cerinza Murcia Oscar Javier , Osorio Guerrero Karen Viviana
Published: December 2021

Este manual sintetiza recomendaciones, consideraciones y conceptos técnicos para la multiplicación de semilla del cultivar Veranera, conservando sus cuatro atributos de calidad: genética, física, fisiológica y sanitaria. Esta información se pone a disposición de agricultores, asistentes técnicos y personas relacionadas con el sector agropecuario de la región que estén interesados en la propagación de este cultivar como una opción nutricional para sus sistemas productivos. Las recomendaciones técnicas descritas en este manual favorecen y dinamizan la producción de semilla de calidad y contribuyen significativamente al sistema de producción de leguminosas forrajeras para los Llanos Orientales de Colombia.
Designing a Cancer Prevention Collaborative Goal-Setting Mobile App for Non-Hispanic Black Primary Care Patients: An Iterative, Qualitative Patient-Led Process
Authors: Resnick Daniel , Kearney Matthew D , Smith Jazmine M , Bautista Allison , Jones Liz , Schapira Marilyn M , Aysola Jaya
Published: December 2021

Background

There remains a need to engage at-risk primary care populations in cancer prevention behaviors, yet primary care physicians often lack the time or resources to discuss these behaviors with their patients.

Objective

The objective of this study is to evaluate the content, usability, and acceptability of a mobile app that leverages insights from goal-setting and social network literature to facilitate cancer prevention goal setting, tracking, and sharing between non-Hispanic Black primary care patients and their social ties.

Methods

We recruited eligible non-Hispanic Black primary care patients (aged ≥18 years) from 2 practice sites in West Philadelphia, using nonprobabilistic purposive sampling. We conducted semistructured interviews with 5 to 7 participants over 3 weeks to solicit feedback on paper mock-ups of the app, iteratively adapting these mock-ups after each set of interviews. Thereafter, and informed by initial feedback, we created an electronic beta version of the app and sought acceptability and usability feedback from a different set of participants. Then, we conducted content analysis of all user responses to search for unifying themes on acceptability and usability of both the initial mock-ups and beta version of the app. We further assessed app usability using questions derived from the System Usability Scale.

Results

A total of 33 non-Hispanic Black primary care patients participated in this study. The mean age was 49 (SD 13) years, and 26 (79%) out of 33 participants identified as female. Semistructured interviews revealed three primary generalizable insights from our target population: the framing of each goal and its relevance to cancer impacted the likelihood that the goal would be chosen, participants thought that sharing health goals with others facilitates health behaviors, and most participants found it motivating to see other users’ goal progress, while still collaborating with these users on their health goals. An overarching insight that permeated across each theme was the participants’ desire to customize and personalize the app. Usability testing revealed that 100% (33/33) of participants found the app easy to use, and 76% (25/33) of participants reported that they would like to use this app frequently.

Conclusions

Cancer prevention in the modern era must include options that are accessible to all, but this does not mean that all options must be universal. This study’s iterative process led to the development of a cancer prevention mobile app that non-Hispanic Black primary care patients deemed usable and acceptable and yielded noteworthy insights about what intended end users value in setting and accomplishing health goals.
A Smartphone-Based Intervention as an Adjunct to Standard-of-Care Treatment for Schizophrenia: Randomized Controlled Trial
Authors: Ghaemi S Nassir , Sverdlov Oleksandr , van Dam Joris , Campellone Timothy , Gerwien Robert
Published: December 2021

Background

Antipsychotic medications have limited benefits in schizophrenia, and cognitive behavioral therapy may be beneficial as an adjunct. There may be potential for implementing mobile cognitive behavioral therapy–based treatment for schizophrenia in addition to standard antipsychotic medications.

Objective

This study aims to determine whether PEAR-004, a smartphone-based investigational digital therapeutic, improves the symptoms of an acute psychotic exacerbation of schizophrenia when it is added to standard treatments.

Methods

This was a 12-week, multicenter, randomized, sham-controlled, rater-blinded, parallel group proof‑of‑concept study of 112 participants with moderate acute psychotic exacerbation in schizophrenia. This study was conducted in 6 clinical trial research sites in the United States from December 2018 to September 2019. The primary outcome, change in Positive and Negative Syndrome Scale (PANSS) from baseline to week 12 or the last available visit, was analyzed using the mixed-effects regression model for repeated measures, applied to an intent-to-treat sample.

Results

The total PANSS scores slightly decreased from baseline over the study period in both groups; the treatment difference at day 85 between PEAR-004 and sham was 2.7 points, in favor of the sham (2-sided P=.09). The secondary scales found no benefit, except for transient improvement in depressive symptoms with PEAR-004. Application engagement was good, and patient and clinical investigator satisfaction was high. No safety concerns were observed. There was some evidence of study site heterogeneity for the onboarding processes and directions on PEAR-004 product use at baseline and throughout the study. However, these differences did not affect the efficacy results.

Conclusions

In the largest-to-date randomized, sham-controlled study of a digital therapeutic in schizophrenia, PEAR-004 did not demonstrate an effect on the primary outcome—total PANSS scores—when compared with a nonspecific digital sham control. The secondary and exploratory results also did not demonstrate any notable benefits, except for possible temporary improvement in depressive symptoms. This study provided many useful scientific and operational insights that can be used in the further clinical development of PEAR-004 and other investigational digital therapeutics.

Trial Registration

ClinicalTrials.gov NCT03751280; https://clinicaltrials.gov/ct2/show/NCT03751280
A Patient-Reported Outcome Tool to Triage Total Hip Arthroplasty Patients to Hospital or Video Consultation: Pilot Study With Expert Panels and a Cohort of 1228 Patients
Authors: Pronk Yvette , Pilot Peter , van der Weegen Walter , Brinkman Justus-Martijn , Schreurs Berend Willem
Published: December 2021

Background

The digital transformation in health care has been accelerated by the COVID-19 pandemic. Video consultation has become the alternative for hospital consultation. It remains unknown how to select patients suitable for video consultation.

Objective

This study aimed to develop a tool based on patient-reported outcomes (PROs) to triage total hip arthroplasty (THA) patients to hospital or video consultation.

Methods

A pilot study with expert panels and a retrospective cohort with prospectively collected data from 1228 THA patients was executed. The primary outcome was a PRO triage tool to allocate THA patients to hospital or video consultation 6 weeks postoperatively. Expert panels defined the criteria and selected the patient-reported outcome measure (PROM) questions including thresholds. Data were divided into training and test cohorts. Distribution, floor effect, correlation, responsiveness, PRO patient journey, and homogeneity of the selected questions were investigated in the training cohort. The test cohort was used to provide an unbiased evaluation of the final triage tool.

Results

The expert panels selected moderate or severe pain and using 2 crutches as the triage tool criteria. PROM questions included in the final triage tool were numeric rating scale (NRS) pain during activity, 3-level version of the EuroQol 5 dimensions (EQ-5D-3L) questions 1 and 4, and Oxford Hip Score (OHS) questions 6, 8, and 12. Of the training cohort, 201 (201/703, 28.6%) patients needed a hospital consultation, which was statistically equal to the 150 (150/463, 32.4%) patients in the test cohort who needed a hospital consultation (P=.19).

Conclusions

A PRO triage tool based on moderate or severe pain and using 2 crutches was developed. Around 70% of THA patients could safely have a video consultation, and 30% needed a hospital consultation 6 weeks postoperatively. This tool is promising for selecting patients for video consultation while using an existing PROM infrastructure.
Sexual Partner Referral for HIV Testing Through Social Networking Platforms: Cross-sectional Study
Authors: Chiou Piao-Yi , Hung Chien-Ching , Chen Chien-Yu
Published: December 2021

Background

Men who have sex with men (MSM) who undergo voluntary HIV counseling and testing (VCT) often report condomless anal sexual intercourse, having many sexual partners, and being exposed to risky sexual networks. Limited research has discussed the application of motivational interviewing and convenience referral platforms to facilitate the referral of sexual partners for HIV testing among MSM.

Objective

This study aimed to evaluate the effects of VCT referral by sexual partners through social networking platforms and the test results after elicited interviews with MSM; compare the characteristics and risk behaviors among MSM tested without referral, index subjects, and referred sexual partners; and explore unknown sexual affiliations through visualizing and quantifying the social network graph.

Methods

This was a cross-sectional study. Purposeful sampling was used to recruit index subjects from a community HIV screening station frequented by MSM in Taipei City on Friday and Saturday nights. Respondent-driven sampling was used to recruit sexual partners. Partner-elicited interviews were conducted by trained staff before VCT to motivate MSM to become index subjects and refer sexual partners via the Line app, or to disclose the accounts and profiles of sexual partners on relevant social networking platforms. Referred sexual partners received rapid HIV testing, and the recruitment process was repeated until leads were exhausted.

Results

After the interviews, 28.2% (75/266) of MSM were successfully persuaded to become index subjects in the first wave, referring 127 sexual partners via the Line app for rapid HIV testing and disclosing 40 sexual partners. The index subjects and tested sexual partners had more sexual partners (F2=3.83, P=.02), more frequent anal intercourse (F2=10.10, P<.001), and higher percentages of those who had not previously received HIV testing (χ21=6.1, P=.047) compared with MSM tested without referrals. The new HIV-seropositivity rate among tested sexual partners was 2.4%, which was higher than the rate in the other 2 groups. The social network analysis revealed the following 4 types of sexual affiliation: chain, Y, star, and complicated. Among the HIV-negative sexual partners, 26.9% (43/160) had sexual affiliations with HIV-positive nodes, and 40% (10/25) were untested sexual partners with a direct sexual affiliation with an HIV-positive node. Four transmission bridges were found in the network graph.

Conclusions

Partner-elicited interviews can effectively promote referral for HIV testing and case identification via Line, and can clarify unknown sexual affiliations of MSM to facilitate the development of a tailored prevention program. Social network analysis is needed for an insightful understanding of the different network structures.
Study of the effect of high blood pressure on the kidney in Children with COVID-19 (Preprint)
Authors: Hossain Mir
Published: December 2021

UNSTRUCTURED

Hypertension is considered as a comorbid condition for the novel coronavirus 2019 (COVID-19). However, there are no reports of “Hypertension crisis” as a presentation or comorbidity of the COVID-19 infection in pediatric patients. In this retrospective observational study, we collected data from total six pediatric patients, diagnosed with confirmed COVID-19 positive who had presented with acute severe hypertension. The mean age of patients was 4.2 years. Four cases were with newly diagnosed nephrotic syndrome and two with chronic kidney disease who were on regular dialysis with no edema or sign of fluid overload, were enrolled. The lowest and highest systolic blood pressures at the time of admission were 160 mmHg and 200 mmHg, respectively. The diastolic blood pressures were between 100-155 mmHg. All patients treated with Labetalol infusion titrated to maximum dosage and continued for at least one week. Our reported children had resistant hypertension and their blood pressure had been controlled with four or five antihypertensive medications. It is crucial to consider the diagnosis of COVID-19 in a patient presenting with a hypertension crisis, even in the absence of classic signs of the virus. Thus from our study we strongly recommend the medical practitioners to consider the probability of COVID-19 infection in cases presenting to the hospital with acute severe hypertension.
Appeal of Editor-in-Chief
Authors: Pankiv V.I.
Published: December 2021

No abstract
Insulin index of food products, its role in type 2 diabetes mellitus in overweight patients
Authors: Jargin S.V.
Published: December 2021

No abstract
Leptin and adiponectin in patients with chronic kidney disease and secondary hyperparathyroidism
Authors: Karlovich N. , Mokhort Т. , Sazonоva Е.
Published: December 2021

Background. The results of studies evaluating the levels of adiponectin, leptin and their ratios in chronic kidney disease (CKD) are conflicting. It is assumed that hyperleptinemia and changes in adiponectin clearance are consequences of a decrease in the glomerular filtration rate, they exacerbate renal impairment and may affect the prognosis of survival due to cardiovascular events. It is known that secondary hyperaparathyroidism is the most frequent complication of CKD, which not only affects calcium-phosphorus metabolism and bone tissue, but also contributes to the development of pathological processes involving other hormonal and metabolic markers. Of greatest interest is the assessment of adipocytokine levels in the development of secondary hyperparathyroidism against the background of CKD as an independent factor of increasing cardiovascular risks. The purpose of the study was to assess adipocytokine levels (adiponectin, leptin) and their ratios in patients with different stages of chronic kidney disease and their relationship with manifestations of secondary hyperparathyroidism. Materials and methods. This cross-sectional study enrolled 160 people with CKD and 40 healthy individuals as a comparison group. Results. Leptin level reduction and an increase in the proportion of patients with hypoleptinemia with a decrease in the glomerular filtration rate were found, which may be an important factor determining nutritional status. Correlations were revealed between leptin level, body mass index (ρ = 0.411) and patients’ age (ρ = 0.189), as well as between leptin/adiponectin and adiponectin/leptin ratios (ρ = 0.395 and ρ = –0.395) and body mass index in patients with CKD persisting in subgroups by stage of renal failure. A relationship was found with sex for leptin and a decrease in its levels below normal values in both men and women. Conclusions. The proportion of patients with hyperadiponectinemia was significantly higher among those with end-stage CKD compared to patients with stages 1–2. There was no statistically significant relationship between adipocytokine and parathyroid hormone levels and the presence of secondary hyperparathyroidism in patients examined.
Decrease in the efficacy of glucagon-like peptide-1 receptor agonists: what is the reason?
Authors: Kushnarova N.M. , Zinych O.V. , Korpavchev V.V. , Kovalchuk A.V. , Prybyla O.V. , Shyshkan-Shishova K.O.
Published: December 2021

The review deals with the drugs of a group of glucagon-like peptide-1 receptors agonists (GLP-1RA) the action of which is based on the incretin effect. In addition to insulinotropic and glucagonostatic action, GLP-1RA contributes to the improvement of glycemic control, a decrease in body weight, and also reduces cardiovascular effects in diabetic patients. The members of this group are divided into short- and long-acting preparations that is determined by their pharmacodynamic properties. Studies have shown that the long-acting GLP-1RA, which are administered once a week, demonstrate better glycemic control with a similar or less risk of the hypoglycemia and gastrointestinal side effects than their short-acting analogues. However, with long-term use of GLP-1RA, there is a reduction in the hypoglycemic action associated with a decrease in the inhibition of intestinal motility due to the phenomenon of tachyphylaxis (desensitization) of the GLP-1 receptors as a result of the vagus nerve activation. Promising means to overcome this shortcoming are considered, such as the development of modified and combined coagonists of dipeptidyl peptidase 1 receptors, as well as oral forms of GLP-1RA. In addition, we have described possible mechanisms influencing the effectiveness of GLP-1RA due to the production of antibodies to various drugs in this group, and the relationship between the effects of incretin mimetics with the state of the intestinal microbiota. In conclusion, the group of incretin-based drugs provides broad perspectives for use in type 2 diabetic patients, with the possibility of correction of both basal and prandial glycemia, and new efficient and safe forms of drugs of this group are actively creating.
Comparison Study of Battery & Supercapacitor Standalone Storage System Based Light Electric Vehicle Using MATLAB/SIMULINK
Authors: Vankadari Praveen
Published: December 2021

Abstract: Because of rising air pollution and finite oil supplies, the transportation sector is transitioning from IC engine vehicles (ICEV) to EV (Electric Vehicle). However, because of the constraints imposed by the energy storage, there are still some questions about EV's performance and dependability. In our proposed system, a comprehensive analysis has been carried out on a Light EV configuration having a propulsion system driven by a BLDC motor supplied by a Energy storage system (ESS) consisting of a Battery or Supercapacitor. To gain an understanding of the electric vehicle driving dynamics, it is first simulated based on fundamental knowledge about electric vehicles. Then each component and their modelling with control strategies are developed to get a clear picture of the computation of various constraints in EV during its operation. Later parts of this study are dedicated to examining their energy and power management during the acceleration and deceleration phases of the vehicle for battery and supercapacitor standalone operations separately with their key results tabulated using MATLAB/Simulink. Keywords: EV (Electric Vehicle), BLDC motor, Energy storage system, Battery, Supercapacitor, Energy Management System.
The Change of Female Consciousness in Ding Lings Novel Creation
Authors: Qizi Mamatova Dilshoda Mashrab
Published: December 2021

Abstract: This article first explains the concept of female consciousness and the role of Ding Ling’s literature in female consciousness; then it elaborates on the female meaning in Ding Ling’s novel creation. The development and transformation of consciousness, from resistance to questioning to attachment; then an introduction to the writers who created female consciousness during the revolutionary period in both literature and life and compare; finally, introduced the content and characteristics of current female consciousness, reflecting the fact that female consciousness will gradually become successful. Keywords: Ding Ling's novels, female consciousness change
A study on resonance characteristics of hydraulic structures and buildings conducted using small-size models
Authors: Makarov Konstantin N. , Yurchenko Elena E. , Biryukbaev Erik K. , Yurchenko Vasilisa E.
Published: December 2021

Introduction. The study focuses on resonance characteristics of a hydraulic engineering structure, such as a groin, land retention works on an artificial island, and a school building. Any structure, exposed to dynamic effects of natural or man-induced origin, can be validly simulated as a mechanical resonator. Models are made of materials that have electro-elastic properties allowing to measure responses to induced oscillations, or changes in an alternating electric field, and reevaluate the physical characteristics later.

Materials and methods. Small-size physical models of structures are made of electro-elastic materials, such as organic glass and ABS plastic, used for 3D printing. A laboratory test bench, composed of an oscillator and a personal computer, used as an oscillograph, was applied to conduct the testing. Mathematical modeling was performed using SolidWorks software packages. Oscillation modes and structural responses, featuring different response amplitudes, were identified. Models of structures were studied in different contexts, including restraint and free bearing.

Results. It has been found that frequencies of the first mode of oscillations in a restrained model correspond to the fourth mode of a model in case of free bearing. Mutual correlation of eigenfrequencies of oscillations in small-size models, made of ABS plastic and organic glass, is demonstrated.

Conclusions. The applicability of ABS plastic as the material of small-size physical models of buildings and structures has been proven for the purpose of identifying resonance frequencies of the prototypes. The co-authors have developed an integrated physical and mathematical modeling method that entails the use of SolidWorks software packages. This method allows to identify resonance frequencies, which are most dangerous for structures. Different structure support patterns allow to apply the geometric scale to obtain resonance frequencies when translating small-size model results to natural values and, hence, identify the vulnerability of structures to dynamic effects.
CONTROL SYSTEM FOR STRUCTURURALLY AND PARAMETRICALLY UNDEFINED NON-AFFINE PLANT WITH NEUTRAL TYPE DELAY AND CONTROL DELAY
Authors:   L.V. Nikiforova Amur State University, Nikiforova L.V.
Published: December 2021

The article deals with the synthesis of a controller for non-affine in input plant with neutral type delay and control delay, whose state variables are not available for direct measurement. The controller constructed on the basis of the hyperstability criterion compensates for the effects of delays, interference, parametric and structural uncertainties in the system.
IMPLEMENTATION OF AN ADAPTIVE CONTROL ALGORITHM WITH A REFERENCE MODEL FOR PROGRAMMABLE LOGIC CONTROLLERS
Authors:   A.N. Rybalev Amur state university, Rybalev A.N.
Published: December 2021

The paper proposes approaches to the software implementation of an adaptive control system with a reference model and parametric adjustment of the regulator on programmable logic con-trollers (PLC) and with practical evaluation of synthesized systems on combined models, includ-ing a simulation model of the controlled plant and a virtual or real controller.
MODELING OF PACKING DENSITY OF THE SIMPLEST HEXAGONAL LATTICE. I
Authors:   D.V. Fomin Amur State University, Fomin D.V.
Published: December 2021

The article deals with the primitive and conventional unit cells of the cubic and densely packed hexagonal crystal lattices. The author analyzes the methods used for determining the spatial packing density and the distance between particles in a crystal. The spherical and cubic models of packing of equal-sized non-overlapping spheres are also considered. A comparative assess-ment of their effectiveness based on practical calculations is presented.
HISTORY OF DISCOVERY AND STUDY OF «ZOLOTAYA GORA» DEPOSIT OF PRIAMUR GOLD-BEARING PROVINCE (AMUR REGION, RUSSIA)
Authors:   Anton Vladimirovich Melnikov Institute of Geology and Nature Management FEB RAS, MELNIKOV ANTON VLADIMIROVICH , STEPANOV VITALY ALEKSEEVICH ,   VITALY ALEKSEEVICH STEPANOV Research Geotechnological Center FEB RAS
Published: December 2021

Information about the history of discovery, development and study of the gold ore deposit «Zolotaya Gora» in Priamur gold-bearing province is present. The deposit is represented by six gold-sulfide-quartz veins located in the zone of crumpling and diaphthoresis along the gneisses and crystalline schists of the Archean. Ore bodies intersect with diorite porphirites of the Mesosoic age. The deposit had the richest gold-sulfide-quartz ores in the Amur region with an average gold grade of about 120-140 g/t. The isotopic age of mineralization, determined by Rb-Sr method, is 155±7 million years.
BAMSKY GOLD DEPOSIT IN THE AMUR REGION: HISTORY OF DISCOVERY AND STUDY (FAR EAST, RUSSIA)
Authors:   Anton Vladimirovich Melnikov Institute of Geology and Nature Management FEB RAS, MELNIKOV ANTON VLADIMIROVICH , STEPANOV VITALY ALEKSEEVICH ,   VITALY ALEKSEEVICH STEPANOV Research Geotechnological Center FEB RAS
Published: December 2021

The materials on discovery and study of the Bamskoye gold deposit of the Amur province are given. The field was discovered in 1979 during lithogeochemical survey of 1: 200000 scale. The carried out prospecting and exploration work established a large scale of the field. An overview of publications on geological and structural features of the deposit, geochemistry and mineral composition of ores was made. It is indicated that the Bamskoye deposit may be the basis of the gold mining industry of the Amur Region for the coming decades.
ANALYSIS OF THE TYPES OF LOADING AND STUDY OF THE OPTIMAL FORM OF THE SAMPLE FOR STUDYING THE DEFORMATION PROPERTIES OF PLANE FIBER-CONTAINING MATERIALS
Authors:   ALEXANDER VLADIMIROVICH STANIYCHUK Amur State University, STANIYCHUK ALEXANDER VLADIMIROVICH
Published: December 2021

The article analyzes the types of loading of samples of flat materials. Tests were carried out to identify the optimal shape of the sample. An acceptable sample shape for studying the deformation properties of flat fiber-containing materials has been proposed.
STATISTICAL ANALYSIS OF FINANCIAL RESULTS OF THE ORGANIZATIONS OF THE AMUR REGION FOR 2000-2019
Authors:   ANZHELIKA VALERIEVNA VASILIEVA Amur State University, VASILIEVA ANZHELIKA VALERIEVNA
Published: December 2021

The article provides a statistical analysis of the financial results of the activities of organizations in the Amur Region before and during the coronavirus pandemic. It was revealed that the largest share of enterprises and organizations of the Amur Region is concentrated in wholesale and retail trade, which is explained by the ease of entry of enterprises into this market. In the course of the study, it was found that the accounts payable of the enterprises of the Amur Region exceeds the accounts receivable. Enterprises and organizations in the region do not have sufficient financial resources to pay off their obligations to creditors.
COMPUTER VISUALIZATION OF THE APPEARANCE OF THE INDIGENOUS PEOPLES OF THE AMUR REGION
Authors:   VLADISLAV EVGENIEVICH MATVEEV Amur State University, MATVEEV VLADISLAV EVGENIEVICH , ALEKSANOV ROMAN ANDREEVICH ,   ROMAN ANDREEVICH ALEKSANOV Amur State University
Published: December 2021

In this paper, a comparison is made between two methods of computer reconstruction and visualization of human appearance on the example of the indigenous peoples of the Amur region. Visualization takes place using modeling from an average image of a person from a photograph and using direct reconstruction from human remains (skull). This work assumes knowledge in the field of information technology, including virtual modeling.
A Recent Overview: In Situ Gel Smart Carriers for Ocular Drug Delivery
Authors: Singh Mandeep , Dev Dhruv , Prasad D.N.
Published: December 2021

Delivery of the drug to the ocular area is blocked by the protective layers covering the eyes; it has always been a major problem to find effective bioavailability of the active drug in the ocular area due to the short duration of precorneal majority ocular stay. Direct delivery systems combine as well as oil, solution, and suspension, as a result, many delivery systems are not able to effectively treat eye diseases. Many works have been done and are being done to overcome this problem one of which is to use in-situ to build polymeric systems. Ocular In-situ gelling systems are a new class of eye drug delivery systems that are initially in solution but are quickly transformed into a viscous gel when introduced or inserted into an ocular cavity where active drugs are released continuously. This sol-to-gel phase conversion depends on a variety of factors such as changes in pH, ion presence, and temperature changes. Post-transplanting gel selects viscosity and bio-adhesive properties, which prolongs the gel's stay in the ocular area and also releases the drug in a long and continuous way unlike conventional eye drops and ointments. This review is a brief overview of situ gels, the various methods of in situ gelling systems, the different types of polymers used in situ gels, their gel-based methods, and the polymeric testing of situ gel.

Keywords: In-situ gel, Polymers, and ion triggered in-situ gel, Mechanism, Evaluation parameters
Can intermittent fasting help in stem-cell rejuvenation?
Authors: Seshadhri S , Shanmuga Sundaram Rajagopal , Sambathkumar Ramanathan
Published: December 2021

Background: Human tissues are sustained by stem cells, the balance between stem cell self-renewal and differentiation, and cell death is the crucial element of haemostasis, which plays a vital role in tissue remodelling. Stem cell therapy is recognized as regenerative medicine. We can stimulate stem cell growth/regeneration through various events.

Objectives: In this review, we illustrate whether fasting can stimulate stem cell regeneration.

Methodology: A literature survey was undertaken to gather recent research and address the effects of fasting on stem cell renewal, which was the review's purpose.

Results:  Enterocytes in drosophila were restored after exposure to the dietary restriction. As the result, fasting before etoposide exposure safeguarded mice against harm caused by etoposide when compared with the fed group. A study conducted on the effects of periodic fasting in yeast, mice, and humans shows the increase in lifespan and stress resistance of yeast fasting reduces the risks due to age factors and diseases like diabetes, cardiovascular diseases and promotes a healthy life span of mice and human.

Conclusion: Dietary limitations will be used in conjunction with the existing therapeutic approach as adjuvant therapy. It will be a more effective treatment. Fasting has the potential to protect against the negative effects of chemotherapy while also boosting stem cell regeneration, according to preclinical findings. Even though regenerative medicine and stem cell therapy are still in their embryonic stage, greater interventions are needed to show the target pathway of fasting in stem cell renewal.

Keywords: Fasting, stem cell regeneration, emerging therapy.
Theoretical Aspects of the Territorial Approach to Region and Supply Chain Management
Authors: Tyapukhin A. P.
Published: December 2021

The territorial approach is the basic approach to a region management. At the same time, the “territory” component is the basis of the logistics complex used in Supply Chain Management. In this regard, a need is to clarify and supplement the theory and methodology of the territorial approach to the management of both the region and the supply chains.

The subject of this study is the relationship between the regional authorities and the focus enterprise of the supply chain regarding the development of the territories and resources of the region on a mutually beneficial basis.

The research methods are methods of analysis and synthesis, induction and deduction, as well as classification, and the tools are binary matrices that provide for the joint use of two classification attributes of the object under study and their dichotomies.

The results of this study are the management principles by the competitiveness and sustainability of the management object; classifications of approaches to the management by the region and supply chains; of territories from the point of view of the focus enterprise of the supply chain and the region; the management decisions in the interaction of regions with the links of supply chains; the sequence of the formation of supply chains and the development of territories and resources of the region on the basis of the territorial approach and the relationship between them.

The obtained results allow to reduce the costs and time for the development of territories and resources of the region by reducing the lost profits of the supply chain links due to their rational placement and increasing sustainability by achieving a synergistic effect both by the region and by the supply chains.
A Person for Local Self-Government or Local Self-Government for a Person
Authors: Shamahov V. A.
Published: December 2021

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Repercusión de arquitectura limpia y la norma ISO/IEC 25010 en la mantenibilidad de aplicativos Android
Authors: Arias-Orezano José Francisco , Reyna Barreto Benjamín David , Mamani-Apaza Guillermo
Published: December 2021

La constante actualización de los aplicativos móviles está relacionada con el desarrollo continuo que demandan las necesidades del usuario, la tecnología y, sobre todo, los nuevos dispositivos. En efecto, esta ininterrumpida evolución, y la complejidad misma del aplicativo, hace que su mantenimiento no garantice la estabilidad cuando se agregan nuevas funcionalidades o se actualicen las versiones del sistema operativo. El objetivo de este estudio fue establecer el impacto de la implementación de arquitectura limpia y de la norma ISO/IEC 25010 en la mantenibilidad del aplicativo móvil Educar Teacher. El diseño de la investigación fue ex post facto cuasi experimental de corte transversal, considerando los aplicativo Educar Teacher y CRM Distribución como grupo experimental y de control, respectivamente, donde se evaluó y se comparó la mantenibilidad de ambos, considerando como unidad de análisis los paquetes, clases y líneas de código. La variable independiente fue arquitectura limpia y norma ISO/IEC 25010, y la dependiente fue mantenibilidad, la cual se trabajó con los criterios de analizabilidad, estabilidad, testeabilidad y cambiabilidad. La muestra fue censal y estuvo conformada por 693 paquetes, 2037 clases y 168 217 líneas de código del aplicativo Educar Teacher. De acuerdo con los resultados, se concluye que al desarrollar con arquitectura limpia y norma ISO/IEC 25010, el aplicativo Educar Teacher logra una repercusión positiva en la mantenibilidad basado en los criterios de analizabilidad, estabilidad, testeabilidad y cambiabilidad de 7 %, 56 %, 0.7 %, 0.9 %, respectivamente.
Alteración de la entropía en la precuña y la corteza cingulada posterior en la enfermedad de Alzheimer: estudio de resonancia magnética funcional en reposo
Authors: Puche Aura C. , Ochoa-Gómez John Fredy , Agudelo-Londoño Yésika Alexandra , Rodas-Marín Jan Karlo , Tobón-Quintero Carlos Andrés
Published: December 2021

El cerebro humano ha sido descrito como un sistema complejo. Su estudio por medio de señales neurofisiológicas ha desvelado la presencia de interacciones lineales y no lineales. En este contexto, se han utilizado métricas de entropía para descubrir el comportamiento cerebral en presencia y ausencia de alteraciones neurológicas. El mapeo de la entropía es de gran interés para el estudio de enfermedades neurodegenerativas progresivas como la enfermedad de Alzheimer. El objetivo de este estudio fue caracterizar la dinámica de las oscilaciones cerebrales en dicha enfermedad por medio de la entropía y la amplitud de las oscilaciones de baja frecuencia a partir de señales Bold de la red por defecto y la red de control ejecutivo en pacientes con Alzheimer e individuos sanos, utilizando una base de datos extraída de la serie de estudios de imágenes de acceso abierto. Los resultados revelaron mayor poder discriminatorio de la entropía por permutaciones en comparación a la amplitud de fluctuación de baja frecuencia y la amplitud fraccional de fluctuaciones de baja frecuencia. Se obtuvo un incremento de la entropía por permutaciones en regiones de la red por defecto y la red de control ejecutivo en pacientes. La corteza cingulada posterior y la precuña manifestaron característica diferencial al evaluar la entropía por permutaciones en ambos grupos. No hubo hallazgos al correlacionar las métricas con las escalas clínicas. Los resultados demostraron que la entropía por permutaciones permite caracterizar la función cerebral en pacientes con Alzheimer, además revela información sobre las interacciones no lineales complementaria a las características obtenidas por medio del cálculo de la amplitud de las oscilaciones de baja frecuencia.
Segmentación multinivel de patrones de Gleason usando representaciones convolucionales en imágenes histopatológicas
Authors: Gómez Andrés , León-Pérez Fabián , Plazas-Wadynski Miguel , Martínez-Carrilo Fabio
Published: December 2021

El sistema de puntuación de Gleason es el más utilizado para diagnosticar y cuantificar la agresividad del cáncer de próstata, estratificando regionalmente patrones anormales en imágenes histológicas. A pesar de ello, estudios recientes han reportado valores moderados de concordancia de 0.55, según el valor kappa en el diagnóstico de la enfermedad. Este estudio introduce una representación convolucional para la segmentación y estratificación semántica de regiones en imágenes histológicas implementando la puntuación de Gleason y tres niveles de representación. Para ello, en un primer nivel, se entrenó una red regional de tipo Mask R-CNN con anotaciones completas, lo que permitió definir delineaciones regionales, siendo efectivo en localizaciones con estructuras generales. En un segundo nivel, usando la misma arquitectura, se entrenó un modelo únicamente con anotaciones superpuestas del primer esquema, y que constituyen regiones con dificultad de clasificación. Finalmente, un tercer nivel de representación permitió una descripción más granular de las regiones, considerando las regiones resultantes de las activaciones del primer nivel. La segmentación final resultó de la superposición de los tres niveles de representación. La estrategia propuesta se validó y entrenó en un conjunto público con 886 imágenes histológicas. Las segmentaciones así generadas alcanzaron una media del Área Bajo la Curva de Precisión-Recalificación (AUPRC) de 0.8 ± 0.18 y 0.76 ± 0.15 respecto a los diagnósticos de dos patólogos, respectivamente. Los resultados muestran niveles de intersección regional cercanos a los de los patólogos de referencia. La estrategia propuesta es una herramienta potencial para ser implementada en el apoyo y análisis clínico.
ANALISIS ZAT BESI, ZINK, DAN KALSIUM PADA FORMULA POLIMERIK UNTUK PENCEGAHAN STUNTING
Authors: Hendrayati Hendrayati , Adam Adriyani , Sunarto Sunarto
Published: December 2021

Latar Belakang. Faktor asupan zat gizi, zat gizi makro, zat gizi mikro, dan kejadian infeksi merupakan faktor langsung yang dapat menyebabkan kejadian stunting pada balita. Sumber nutrisi yang memenuhi persyaratan kuantitatif dan kualitatif dapat digunakan untuk memperbaiki asupan. Pola pemberian makan pada anak memerlukan cara tertentu agar menarik dan mudah dicerna. Formula polimerik merupakan makanan mudah dicerna, siap saji, dan siap olah. Formula polimerik dengan komposisi makronutrien seperti protein, karbohidrat, lipid dalam bentuk utuh, vitamin lengkap, dan mineral telah dikembangkan dalam penelitian ini. Formula polimerik yang dikembangkan memiliki densitas energi tinggi yaitu 1,5–2 Kkal/mL. Tujuan. Penelitian ini bertujuan untuk mengetahui kandungan zink, zat besi, dan kalsium sebagai sumber mineral yang potensial dalam mendukung pencegahan dan penanggulangan stunting pada balita. Metode. Penelitian ini menggunakan one shot case study design sebagai pre experimental design. Penelitian ini dilakukan selama empat bulan. Analisis kandungan zink, zat besi, dan kalsium menggunakan metode 18–13–1/MU/SMM–SIG (ICP OES):18–13–1/MU/SMM-SIG (ICP OES) dan 18–13–1/MU/SMM-SIG (ICP OES) pada PT Saraswanti Indo Genetech (PT SIG) Laboratory, Bogor, Jawa Barat untuk empat formulasi formula polimerik. Hasil. Hasil penelitian menunjukan bahwa kadar zink tertinggi 3,05 mg memenuhi 100 persen angka kecukupan gizi (AKG) kebutuhan balita. Pada anak usia 4–6 tahun, kandungan zat besi tertinggi 6,66 mg memenuhi 66,6 persen AKG dan kandungan kalsium tertinggi 308,36 memenuhi 30,8 persen AKG balita. Kesimpulan. Formula polimerik mengandung zink, zat besi, dan kalsium yang bervariasi pada keempat formulasi. Formula polimerik yang direkomendasikan untuk pencegahan stunting adalah formula tiga dengan kandungan zink dan kalsium tertinggi serta zat besi.