bluuebunny/crossref_metadata_2025 huggingface dataset:
Adjuvant Transarterial Chemoembolization for Patients with Intrahepatic Cholangiocarcinoma after Surgical Resection: A Systematic Review and Meta-analysis
Authors: Wang Lang , Wen Xiaoling , Zhuang Liping , Fang Kewei , Shen Jiang
Published: May 2022

Aim: To investigate the efficacy of postoperative adjuvant transarterial chemoembolization (TACE) in patients with intrahepatic cholangiocarcinoma (ICC) after resection.

Methods: Studies were systematically searched until August 2021 in the following databases: MEDLINE, EMBASE, PUBMED, Web of Science, Cochrane Library, Science Direct, and Springer Link. Overall survival (OS) and recurrence-free survival (RFS) were considered as the main outcomes. Pooled hazard ratio (HR) with 95% confidence interval (95%CI) was reported as results for the survival data. Subgroup analysis was conducted on the outcomes stratified by early-stage ICC and intra-arterial chemotherapeutic regimen.

Results: Eleven studies with 2,757 patients were finally included in the study. The pooled HR of OS was 0.68 (95%CI: 0.50-0.87, I 2 =83.7%). The pooled HR of RFS was 1.00 (95%CI: 0.69-1.31, I 2 =88%). Receipt of postoperative adjuvant TACE improved the OS in the early-stage ICC subgroup (HR=0.68, 95%CI: 0.50-0.86, I 2 =54%). Addition of carboplatin could slightly improve the OS (HR=0.6, 95%CI: 0.35-0.85, I 2 =48%). But receipt of postoperative adjuvant TACE (HR=1.06, 95%CI: 0.83-1.29, I 2 =41.2%) or use of carboplatin (HR=1.30, 95%CI: 0.93-1.67, I 2 =0%) caused no significant improvement in the RFS in the early-stage ICC subgroup.

Conclusions: Postoperative adjuvant TACE could improve the OS in ICC patients after hepatectomy but could not prevent late recurrence. Survival benefit was also found in early-stage ICC patients undergoing postoperative adjuvant TACE after hepatectomy. Addition or non-addition of carboplatin in chemoembolization showed a similar OS outcome.
Prevalence of Autoimmune-phenomena behind Chronic Gastritis of Unknown Origin, and their Role in the Poor Histological Outcome of the Stomach: A Single-centre, Retrospective Cross-sectional Study
Authors: Zádori Noémi , Németh Dávid , Szakó Lajos , Váncsa Szilárd , Vörhendi Nóra , Szakács Zsolt , Frim Levente , Hegyi Péter , Czimmer Jozsef
Published: May 2022

Background and Aims: The underlying aetiology of chronic gastritis (CG) often remains unknown due to its underrated significance in clinical practice. However, the role of chronic inflammation of the stomach in the development of atrophy, intestinal metaplasia (IM) and eventually of gastric cancer is well documented. We aimed to explore the possible aetiological factors of CG, determine the prevalence of systemic autoimmune disorders in patients with CG of unknown aetiology, and clarify the role of autoantibodies in the development of precancerous lesions in the stomach.

Methods: This is a retrospective, cross-sectional study, conducted from January 2016 to January 2020, including data from 175 patients with CG. Exclusion criteria were: (1) acute gastritis; (2) reactive gastropathy; (3) gastric cancer; (4) subjects without any serology testing results; and (5) Helicobacter pylori positivity. The primary endpoint was a composite endpoint involving gastric atrophy and IM.

Results: Fifty-five per cent of patients with CG had autoantibodies. Systemic lupus erythematosus (SLE)-related antibodies were positive in most of the cases, including antinuclear antibody (ANA) positivity, which was found in 19.13% of the patients. Autoimmune positivity was shown to be associated with precancerous lesions in the stomach (p<0.001): IM, atrophy and IM with atrophy. Anti-parietal cell antibody positivity seems to be a significant risk factor for IM and IM with atrophy. Autoimmune thyroiditis-related antibodies and ANA positivity by itself were only associated with atrophy; SLE-related antibodies and inflammatory bowel diseases related antibodies (ASCA and ANCA) correlated either with IM or with atrophy. No significant relation was found between any other investigated autoimmune disease-related antibodies and precancerous lesions.

Conclusions: Autoimmune positivity often underlies gastritis of unknown aetiology and predisposes to precancerous lesions in the stomach. These antibodies can serve as non-invasive markers for the of optimal timing of an endoscopic follow-up strategy. Furthermore, CG can be an early symptom of a systemic autoimmune disorder.
Computed Tomography for the Diagnosis of Intraperitoneal Infected Fluid Collections after Surgery for Gastric Cancer. Role of Texture Analysis
Authors: Puia Vlad Radu , Puia Aida , Fetti Alin Cornel , Stefan Paul Andrei , Valean Dan , Herdean Andrei , Rusu Ioana , Vasile Tudor , Lebovici Andrei , Al-Hajjar Nadim
Published: May 2022

Background and Aims: Several computed tomographic (CT) imaging features have been proposed to describe the infection of postoperative abdominal fluid collections; however, these features are vague, and there is a significant overlap between infected and non-infected collections. We assessed the role of textural parameters as additional diagnostic tools for distinguishing between infected and non-infected peritoneal collections in patients operated for gastric cancer.

Methods: From 527 patients operated for gastric cancer, we retrospectively selected 82 cases with intraperitoneal collections who underwent CT exams. The fluid component was analyzed through a novel method (texture analysis); different patterns of pixel intensity and distribution were extracted and processed through a dedicated software (MaZda). A univariate analysis comparing the parameters of texture analysis between the two groups was performed. Afterwards, a multivariate analysis was performed for the univariate statistically significant parameters.

Results: The study included 82 patients with bacteriologically verified infected (n=40) and noninfected (n=42) intraperitoneal effusions. The univariate analysis evidenced statistically significant differences between all the parameters involved. The multivariate analysis highlighted 10 parameters as being statistically significant, adjusted to Bonferroni correction.

Conclusions: Our evidence supports the fact that textural analysis can be used as a complementary diagnostic tool for the detection of infected fluid collections after gastric cancer surgery. Further studies are required to validate the accuracy of this method.
Helicobacter Pylori Colonization Density is an Important Risk Factor for Eradication Therapy
Authors: Demirci Hakan , Ozturk Kadir , Tanoglu Alpaslan , Kilciler Ayse Guldem , Gunal Armagan , Gulsen Mustafa , Uygun Ahmet
Published: May 2022

Background and Aims: Despite the known risk factors, it is not clear why the same treatment protocol for Helicobacter pylori infection (H. pylori) doesnot show a similar effect in patients with common risk factors. We hypothesized that as the severity of H. pylori - induced gastric mucosa inflammation and density increase, the rate of successful treatment decreases. This study aimed to explore the existence of a possible association between gastric H. pylori colonization density and the efficacy of bismuth-containing quadruple eradication therapy.

Methods: A total of 330 patients with H. pylori positive gastritis were initially included; the diagnosis was based on the histopathological examination. H. pylori colonization density was graded according to the Sydney classification: mild (n=101), moderate (104) and severe (98). H. pylori eradication was determined via the 13C-Urea breath test performed eight weeks after therapy.

Results: There was no significant difference in terms of the distributions of age, gender, alcohol consumption, and smoking status among the groups (p>0.05). The successful eradication rates of H. pylori were 87.1%, 78.8%, and 75.5%, respectively, for the mild, moderate, and severe H. pylori colonization groups by per-protocol analysis (p=0.038). The eradication rates of H. pylori were 81.5%, 73.2%, and 67.3% respectively, for the mild, moderate, and severe H. pylori colonization groups by intention-to-treat analysis (p=0.017).

Conclusions: Helicobacter pylori colonization severity might predict the usefulness of eradication therapy in pre-treatment assessment. We recommend the use of more effective therapy regimens for H. pylori eradication in patients with severe densities.
Assessment of the mining potential of the public sector of the coal industry of Ukraine
Authors:   Institute of General Energy of the National Academy of Sciences of Ukraine, 172 Antonovycha str., Kyiv, 03150, Ukraine, Makarov V.M.
Published: May 2022

The projection of the hot water thermal load of the district heating system’s consumers is developed. It is shown that the total heat load of centralized hot water supply systems in Ukraine today is about 3.0 GW. It determines the full potential of maneuvering power of electric heat generators to provide ancillary services to a power system. Moreover, due to the decline of the Ukrainian population and the decrease of demand for thermal energy, it is expected to decline in the future and will reach 1.9 GW in 2050 (down 36.6% compared to 2020). During the non-heating period, under market conditions, it is expected that heat-generating technologies will compete with each other for the ability to supply heat water to the district systems. The solar collectors will be excluded from the market competition as they do not require a fuel, and therefore their use during the non-heating period is the most profitable. Another technology that will be in use is biomass boilers, their minimum reduced weighted average lossless price of thermal energy (Marginal Levelized Price of Energy - MLPOE) is 102 UAH / Gcal. Gas cogeneration technologies also have a great chance to use their thermal capacity (MLPOE - 258 UAH / Gcal), heat pumps (MLPOE - 155 UAH / Gcal), electric boilers (MLPOE - 633 UAH / Gcal) and gas boilers (MLPOE - 964 UAH / Gcal) will also be used. The analysis of different options for providing ancillary services to the power system showed that considering the competition among technologies, the most feasible option is to involve CHP equipped with electric heat generators. This option allows performing both daily regulation of power and load of power system and also regulation during the system’s night minimum load. At the same time, the balancing power for the current situation is about 1.3 GW for daily control and 1.4 GW for regulation during the night minimum load Keywords: coal industry, production technologies, modernization, forecast, development
The forecasted estimation of greenhouse gas emissions from the use of natural gas in the economy of Ukraine
Authors:   Institute of General Energy of the National Academy of Sciences of Ukraine, 172 Antonovycha str., Kyiv, 03150, Ukraine, Stanytsina V.V. , Panchenko G.G. ,   The State Ecological Academy of Postgraduate Education and Management, 35 Metropolitan Vasyl Lypkivskyi str., Kyiv, 03035, Ukraine
Published: May 2022

The article presents a retrospective review of natural gas consumption and greenhouse gas emissions from its consumption. It is determined that greenhouse gas emissions in the country as a whole decreased from 1990 to 2019 by 62.4%, emissions from natural gas consumption – by 71.7%. The potential for energy saving from structural changes in the economy is determined at the level of 5.2 billion m3 and the technological potential for energy saving from the introduction of energy saving measures and replacement of natural gas with other fuels in heat generating plants, including measures implemented in household sector, at the level of 7.5 billion m3 in 2040. Using the method of forecasting long-term demand for energy resources developed at the Institute of General Energy, the forecast of natural gas demand in Ukraine until 2040 is developed for the conservative scenario of economic development taking into account structural changes and technological energy saving in the country and enlarged sections of the economy. Slight growth in natural gas demand is projected to reach 32.9 billion m3 in 2040. The forecast of greenhouse gas emissions only from the use of natural gas by consumer groups and by the country as a whole is calculated. According to the assumption of moderate economic growth and the implementation of energy-saving measures, it is expected to reduce greenhouse gas emissions from natural gas use in 2030 (compared to 2017) and gradually increase after 2030. Therefore, to reduce greenhouse gas emissions after 2030, it is necessary to implement measures and technologies for the decarbonization of the country's economy. To assess the capability of meeting the target already set in Ukraine's 2nd National Contribution to the Paris Agreement, it is necessary to determine projected emissions not only from the use of natural gas but also from the use of coal and petroleum products, and to estimate emissions from other sources, including leakages. Determining the estimation of greenhouse gas emissions from leakages is a separate task. The obtained results allow to determine the largest sources of greenhouse gas emissions from natural gas consumption in the country's economy and to focus further research on identifying ways to reduce emissions. Keywords: forecast, demand, natural gas, greenhouse gas emissions, energy saving potential, populatio
The selection of the method to divide total expenses of energy consumed for the combined production of energy products and its application for coal-fired CHP
Authors:   Institute of General Energy of the National Academy of Sciences of Ukraine, 172 Antonovycha str., Kyiv, 03150, Ukraine, Horskyi V.V.
Published: May 2022

Cogeneration of electric and heat energy is a trend in the modern development of energy production systems in the world. The share of electricity produced by CHP in Ukraine coincides with the share of combined heat and power produced by the G8 + 5 countries and is equal to 11–19%. The fuel's heat utilization rate reaches 75% at CHP in the EU countries. An important energy efficiency indicator, characterizing the full technological cycle of power generation, is the total power intensity of the product. To determine the technical and economic indicators of CHP's operation, the production cost of energy products produced, reasonable tariffs for them, and the payback period of investments, first of all, it is necessary to develop a certain scheme for the allocation of costs for each output product. One of the most important methodological issues in combined energy production is the optimal distribution of expenses between the generation and transmission of electric and thermal energy. So far, there are a number of methods for allocating costs by type of product in cogeneration. All methods give different calculation results, and the discrepancy among them is quite significant. Analyzing and comparing them, one can identify both the advantages and disadvantages of each method, depending on the calculation task. The total energy intensity of energy products output for the station was also calculated, and the distribution of energy consumption between thermal and electric energy was performed according to four methods. As a result of the analysis, the thermodynamic method of cost allocation for the supply of electricity and heat is recommended for use, as it takes into account the value of steam used in the turbine (for electric power generation) and is further supplied for the needs of heat supply. Keywords: cogeneration, distribution of energy consumption, methods of distribution of energy consumption, energy carriers
Optimising confocal Raman microscopy for spectral mapping of cement-based materials
Authors: Zhang K. , Yio M. H. N. , Wong H. S. , Buenfeld N. R.
Published: May 2022

Raman spectroscopy combined with confocal imaging, i.e. confocal Raman microscopy (CRM) is a relatively new technique with huge potential for high-resolution chemical mapping of phase composition and spatial distribution in cement-based materials. However, the effects of sample preparation and various operating parameters on mapping quality has not been systematically studied. This paper optimises CRM for spectral mapping of carbonated and non-carbonated cement-based materials. The effects of sample preparation and scanning parameters on the detection of four main phases (calcite, portlandite, ettringite and unreacted cement) were investigated. Results show that although freshly cut cementitious samples can be analysed as-is, the Raman signals improve with short gentle drying and surface grinding/polishing prior to analysis. Increasing laser power, exposure time and scan accumulation, and short laser wavelength yields higher signal-to-noise (SNR) ratio in the obtained spectrum. The use of a 4.15 mW laser power, 2 s exposure time and scan accumulation of 2 with 532 nm laser represents a good operating condition for Raman analysis of cement-based materials. This produces SNR > 10 for all investigated phases at short testing time and low risk of laser-induced damage. Microcracking caused by localised heating during closely-spaced mapping can be limited by impregnating the sample with epoxy to protect the microstructure. We show for the first time that CRM can be used to quantify the volume fraction of calcium carbonate and portlandite at high resolution when combined with SEM. The advantages and limitations of CRM for mapping cement-based materials are discussed.
The effect of sarcopenia on erlotinib therapy in patients with metastatic lung adenocarcinoma
Authors: Topcu Atakan , Ozturk Akin , Yurtsever Ismail , Besiroglu Mehmet , Yasin Ayse Irem , Turk Haci Mehmet , Seker Mesut
Published: May 2022

Erlotinib, a tyrosine kinase inhibitor, has been shown to improve the survival of patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer. Sarcopenia is a status with increasing importance in lung cancer, and it may predict a poor prognosis. We aimed to evaluate the impact of sarcopenia on erlotinib therapy and prognosis in patients with EGFR-mutated (exon 19 or 21 L858R) metastatic lung adenocarcinoma. Sarcopenia was defined as skeletal muscle index ≤39 cm2/m2 for women and ≤55 cm2/m2 for men. The patient characteristics, inflammation parameters, clinical and survival outcomes of the erlotinib therapy were examined according to sarcopenia status. We also analyzed the erlotinib treatment-related toxicity. Seventy-two patients were included in our retrospective study, and the mean age of the patients was 63.7 years. A total of 39 (54.2%) patients were diagnosed with sarcopenia. Patients with sarcopenia had a poor prognosis and had a shorter median progression-free survival (PFS) than patients without sarcopenia (10.5 months vs. 21.8 months, p=0.002). Sarcopenia (HR 2.08) and C-reactive protein > 6.5 mg/L (HR 2.57) were determined as independent poor prognostic factors for PFS of erlotinib therapy. Treatment-related toxicity occurred in 34.7% of patients treated with erlotinib, and sarcopenia did not significantly affect treatment-related toxicity. We also found that sarcopenia significantly affected the response to erlotinib. The expected survival outcomes may be low when erlotinib therapy is used in patients with sarcopenia and metastatic lung adenocarcinoma. This study showed that survival and clinical outcomes could be better predicted by detecting sarcopenia in patients with lung cancer using erlotinib.
Adopting proactive results by developing the Shrewd model of pandemic COVID-19
Authors: Shahzad Ashraf , Zeeshan Rasheed , Muhammad Arbaz
Published: May 2022

The unavoidable pandemic situation seems uncontrolled over the past two years. In this aggravated situation, it seems crucial to take inescapable measures to deal with such a defiant disease and it is only possible if the actual pandemic propagation ratio is to be acquainted. Therefore, a shrewd pandemic model is being developed that will generate real-time infection statistics on an hourly, weekly, and monthly basis. This shrewd model utilizes the well-known dataset and when this dataset will be applied to determine the status of three types of infection the number of infected people, the time when the pandemic begins, and the time when the pandemic disappears. The time-based results are generated by conducting simulation in python Simpy framework and the generated results are the hallmark of real-time infection spreading ratio it shows that when the extraordinary measures for infection ratio are indispensable and when it becomes plausible.
Proof of Einstein’s postulates
Authors: BG Golovkin
Published: May 2022

Based on the assumption that the experiment confirms the STR, it is shown that the value of the speed of light is a very slowly decreasing function of its frequency, so that at a frequency of 2.2989.10-18 S-1, the speed of light becomes zero. Such light represents resting particles – photonics that could serve as the Absolute Reference System, but due to their negligible mass, do not have a noticeable effect on the processes taking place. This explains Einstein’s principle of relativity. The formulas for the change in the speed and frequency of light during the transition from one IRS to another, within the measurement error, remain unchanged, which proves the postulate of the constancy of the speed of light in any IRS. It is shown that all STR formulas include not the speed of light, but the fundamental constant C, equal to the speed of light with a frequency ν = ∞. The proposed explanation of the correctness of Einstein’s postulates is logically, apparently, the only possible one.
A mesenchymal chondrosarcoma of the right tibia in a young man requires disarticulation of the right knee: A case study
Authors: Youness Mokhchani , Abderrafia Rachdi , Abdelhay Rabbah , Jalal Boukhriss , Bouchaib Chafry , Mustapha Boussouga
Published: May 2022

Chondrosarcoma is a malignant tumor occupying the 2nd position in terms of frequency, all ages combined, after osteosarcoma [1]. Epidemiological data extracted from cancer registries in Europe indicate an annual incidence of ~0.1/100,000 inhabitants [2]. Mesenchymal chondrosarcoma of bone is a rare high-grade variant of chondrosarcoma (2-13%), which usually has an extra-skeletal (30-40%) or central intramedullary location (15-30%).
[RETRACTED] https://www.facebook.com/Kelly-Clarkson-CBD-Gummies-105983145436466/ v1
Authors: not provided kellybealy
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Analysis of Urban Comfort Level in Java Island Based on Air Temperature and Air Quality in 2015 – 2019
Authors: Saringatin Siti , Ramadan Gian Felix , Widiastuti Elyana Inggrid , Arjasakusuma Sanjiwana
Published: May 2022

The island of Java as the center of activity in Indonesia is experiencing uncontrolled urbanization and industrialization. Urbanization and industrialization are sources of air pollution and increases in air temperature, which can increase the risk of health problems for humans and reduce the comfort level of the city. The assessment of the comfort level based on air temperature uses an outdoor thermal comfort (OTC) index, namely universal thermal climate index (UTCI) and physiological equivalent temperature (PET) as well as air quality assessment based on Air Quality Guideline (AQG) criteria. This study focuses on assessing the comfort level of cities in Java based on the relationship between temperature and air quality human health levels in 2015 to 2019, in 10 cities, namely Jakarta, Bandung, Surabaya, Semarang, Tasikmalaya, Malang, Surakarta, Yogyakarta, Cilegon, and Tegal. The technique used is narrative review, recapitulation of secondary data sources from remote sensing and health data. The year 2019 was classified as extreme because there were indications of strong heat stress in 9 cities based on UTCI criteria and there were 3 cities classified as strong heat stress based on PET criteria. The PM2.5 concentration in Malang and Surabaya is at an unsafe level, while the CO concentration is safe based on the AQG. The recapitulation of health data shows an increase in cases of acute respiratory infections (ARI) in Malang, Jakarta, and Tasikmalaya cities which is in line with the trend of data on increasing air temperature and PM2.5 concentrations.
Dating Adolescents Distribution by Gender and Place of Residence (Rural-Urban Areas): IDHS 2017 Data Analysis in South Kalimantan Province
Authors: Aryati Seri , Dewi Ratri Purnama , Hilmi Zaima
Published: May 2022

The majority of adolescents in Indonesia are already dating. However, the distribution of the dating phenomenon among adolescents varies between provinces in Indonesia. South Kalimantan is the province with the smallest percentage of boyfriend/girlfriend ownership in Indonesia. This study aims to determine the distribution of dating adolescents with comparative analysis of gender and place of residence in the form of rural and urban areas in South Kalimantan in 2017. This study uses secondary data as an analysis tool. Secondary data were obtained from the 2017 Indonesian Demographic and Health Survey (IDHS) on the Adolescent Reproductive Health component. The variables used include two aspects, namely the socio-demographic conditions and dating plus dating behavior in adolescents. The data were then processed and analyzed descriptively quantitatively. The results showed that adolescents in the rural had a greater percentage of boyfriend/girlfriend ownership than urban adolescents. Males are more permissive of sexual dating behavior to premarital sex than females. In this case, both males and females in urban areas are more permissive of premarital sex than males and females in rural areas.
Tourism Revitalization Based on Local Wisdom in ‘Saba Budaya’ of Baduy
Authors: Waluya Bagja , Malihah Elly , Ruhimat Mamat , Wiyanarti Erlina
Published: May 2022

Tourism impact is the multiplier effect. But its development so far caused negative impacts such as the damage to natural environment and degradation of local culture, as happened to tourism in the Baduy tribe. Sustainable cultural tourism and local wisdom-based revitalization in Baduy are necessary. This research aims to dig the value of ‘Saba Budaya Baduy’ as a reference for its revitalization. The research method used is qualitative descriptive. Research result shows that Baduy tribe traditional village has various local wisdom value, both tangible and intangible that can be grouped in the form of historical-philosophical value, the tradition of traditional ceremonies, farming, arts, taking care of nature, community entertainment, and the way of building a home. Aside from having the attraction of scarcity, naturalism, and uniqueness, its local wisdom also holds the value that can be a reference for preservation efforts and the aspects of its revitalization. Revitalization through ‘Saba Budaya Baduy’ refers to the value of local wisdom and sustainable tourism can be implemented to develop Baduy tourism under the desire of the community and protect its sustainability.
Nature and Woman as Symbols of Polyphoria in the Structure of the Cycle of Maternity Rituals
Authors:   Kharkiv State  Academy of Culture, Kukharenko Oleksandr
Published: May 2022

To determine the extent to which the structure of the cycle of maternity rites created by the author reflects the connection with fertility and sacralization, semiotic (landmark, symbolic) results of researchers’ work in this scientific field should be included in the structural and functional analysis. Polyphoria or fertility occupy a fundamental place in maternity rites and are realized in them by semiotic connections that combine the process of growing crops with the delivery of a baby by a woman. Obvious evidence of belonging to fertility of certain episodes, from which the rite is formed, is the use of bread, grain, water, potion, coverlet, sheepskin coat, red threads, yarn. Maternity ritual actions are close to the calendar, preceding the beginning of sowing cereals. And fencing of the pregnant woman’s bed resonates with warnings against the influence of the dead body during funeral rites. Approximately the same effect is produced by the placenta and water after bathing the newborn and the mother, who belong to the afterlife and must be returned from this world to the next. Episodes, which by the nature of the action belong to the feasts or gifts and there are many of them, also show a connection with fertility. There is such a connection in the episodes of the use of sheepskin coats and riding on the carriage of the godparents with the midwife. Of course, these actions and subjects are important only in the structure of the rite, since only in this way the influences of the afterlife and sacralization of reality become possible. In the course of the research, it was established that the created structure of the cycle of maternity rites is able to reflect the level of sacralization and the connection with fertility only partially, since it is a scheme of a particular rite. For productive study of the specified direction, it is necessary to combine a technique of the structural and functional analysis used for construction of the structure of maternity rites, with semiotic and structural-semiotic methods of research.
The Role of the Rural Community in the Fighting Against Drunkenness on the Right-bank Ukraine in the Second half of the 19th – early 20th century
Authors:   nstitute of Art, Folkloristic and Ethnology Studies of National Academy of Sciences of Ukraine named after M. Rylsky, Gorova Vitalina
Published: May 2022

The article analyzes the role of the community in the fighting against drunkenness, which was common among the rural population in the second half of the 19th – early 20th century (on the example of Kyiv, Podillia and Volyn provinces). Ways to solve this problem, which were implemented by the joint efforts of the rural community and with the active participation of clergy, as well as methods of direct public influence on people who abused alcohol and possible punishments for immoral behavior. An important source for our study are the notes of priests, ethnographic material, official documents (instructions, protocols, reports of organizations dealing with social issues), published on the pages of the «Diocesan Information» of the above provinces. The problem of the spread of drunkenness among Ukrainian peasants in the second half of the XIX – early XX century became relevant after the abolition of serfdom, in particular due to the increase in the number of drinking establishments in the villages of that time. Excessive alcohol consumption was condemned by popular morality. Drunkenness was not only a family problem, but also a public one. It was a tradition to take care of the drunken host’s family. He was despised, and such a negative attitude on the part of the community, in some cases, forced him to return to normal. One of the measures taken by the priests to combat drunkenness was the so-called «marriage of sobriety». Parish guardians were actively involved in the fighting against alcoholism. They established rules for peasants to visit taverns, and also regulated and banned the sale of alcoholic beverages. Conclusions are made regarding the social and educational functions of the rural community in the struggle for the morality of the population. The methods of their direct influence were persuasion, encouragement by example, mentoring, or public condemnation and punishment. Conscious representatives of the clergy made great efforts to combat drunkenness. At the initiative of the village priest, the community made collective decisions to close local drinking establishments. Their desire to reduce alcohol abuse was realized through the organization of sobriety societies, which allowed them to unite public efforts to overcome this bad habit. In addition, the societies were engaged in the development of cultural, educational and artistic spheres.
Ethnological research of Ivan Franko: historiography of the late 19th century
Authors:   Taras Shevchenko National University of Kyiv, Konta Rostyslav
Published: May 2022

The article covers the historiography of the late of ХХth century concerning ethnological activity of I. Franko. In this period are formed the basic approaches to assessing the scientific heritage of the scientist as an ethnographer and folklorist. In the literature at this time the basic approaches to an estimation of scientific activity of I. Franko are formed. At the same time, his ethnological scientific achievements are not always properly evaluated. Exceptions can only be made to reviews of ethnographic and folkloristic research in printed editions of Shevchenko Scientific Society in Lviv. Given the diversity of scientific interests of the scientist and his active socio-political activities, the ethnological component of his scientific research was mostly out of the attention of researchers of his work. But in the late XIX century the first estimates of his ethnological and folkloristic activity are observed. At this time, the first assessments of Ivan Franko as a developer of methodological materials for recording ethnographic data, his work as an editor and compiler of ethnographic collections of materials and also as a collector of ethnographic monuments.
Ukrainska Narodna Hromada as Organizer of the Coup d’etat on April 29, 1918
Authors: Liubovets Olena
Published: May 2022

The article analyzes the reasons for the emergence, the main provisions of the political program and the activities of the Ukrainska Narodna Hromada. The Ukrainska Narodna Hromada emerged in Kyiv at the end of 1918. Pavlo Skoropadsky initiated its creation. In his opinion, it should have become the focus and center of the opposition and unite all those dissatisfied with the policy of the Centralna Rada. From the very beginning, the Hromada aimed to prepare for the overthrow of the Centralna Rada and the introduction of strong government in the country. The Hromada included representatives of conservative political parties – the Soius Zemelnykh Vlasnykiv, the Ukrainian Democratic-Agricultural Party, the All-Russian Party of Cadets, as well as soldiers of the 1st Ukrainian Corps and members of the Vilne Kozatstvo, personally associated with P. Skoropadsky. The program of the Hromada was developed, which outlined such issues as rights and freedoms of citizens, forms of government, ways to solve agricultural and labor issues, state language, financial and tax policy, development of transport and roads, education, court, health care. In content, the program is close to the party program of the Cadet Party. Having prepared and carried out a coup d’etat, the Hromada at the same time laid the ideological and theoretical foundations of the domestic political course of the future Ukrainska Derzhava. Its most active members participated in the hetman’s governments, forming the main directions of state policy.
Culture and Life of the Peasants in Dnipropetrovsk Region in the 1920s – 1930s (After the Archival Materials of the All-Ukrainian Academy of Sciences Ethnographic Commission)
Authors:   National Academy of Sciences of Ukraine Maksym Rylskyi Institute for Art Studies, Folkloristics and Ethnology, Borysenko Valentyna
Published: May 2022

The article is aimed at the description of culture and life of the peasants on the base of unique archival materials recorded by the scientists and correspondents of the All-Ukrainian Academy of Sciences Ethnographic Commission in Dnipropetrovsk region in the 1920s – 1930s. The layer of traditional culture, when its structure has been comparatively integral yet, is reflected in folklore-ethnographic materials. The bearers of this culture, peasantry mainly, have been in the extreme critical state of their vital activity. The Soviet regime invasion has frustrated their way of life. Powerful propaganda has caused discrepant feelings in the peasant’s soul. It seems that hope for better life has appeared, but violence against people, appropriation of their property has generated deep doubts in the fairness of this power. The research methodology used during the article writing, includes, first of all, historical, historical-comparative, the method of oral history. The main results: a unique peasant’s confession in 1933, as an example of micro history, which personifies the time life of the whole peasantry, is published in the article for the first time. The practical meaning: this is undervalued material for the specification of fixed postulates in the textbooks in History concerning the thematic of this historical period, promulgation of archival facts for the use during the articles and monographs writing. Originality: the existence of traditional culture in the conditions of traditions deformation and transformation in Dnipropetrovsk region is testified after the archival sources. Scientific novelty: unique treasures of Ethnographic Commission, concerning to the very difficult period in our history, where the peasantry becomes the bystanders of the Bolshevist experiment, are described for the first time. The article type: cognitive, analytical.
Masked polycythemia vera manifested by splanchnic venous thrombosis during pregnancy: a clinical case
Authors: Nadinskaia M. Yu. , Kodzoeva Kh. B. , Sokolova M. A. , Apresyan S. V. , Kryzhanovskaya E. Yu. , Shchukina A. A. , Kitsenko E. A.
Published: May 2022

Ph-negative myeloproliferative disorders such as polycythemia vera (PV), essential thrombocythemia, and primary myelofibrosis are rare clonal hematopoietic diseases that typically occur at age over 50. Only 10–15% of PV cases are diagnosed during the reproductive years, most commonly manifested as splanchnic venous thrombosis (SVT). Here, we demonstrate a case of a 6-weeks pregnant woman with a history of stillbirth and miscarriage presented with SVT. A terminal ileal resection and right hemicolectomy were performed, as well as the appointment of low molecular weight heparin in the postoperative period was initiated that allowed the patient to continue the pregnancy and deliver a child. The JAK2 V617F mutation was detected and masked PV was diagnosed according to bone marrow findings. In this article, we discuss the etiology of SVT in adults and effect of JAK2 V617F mutation on pregnancy outcomes as well as summarize current knowledge about pregnancy outcomes in PV.
Virginia Apgar: in the struggle for newborn’s life
Authors: Makatsariya N. A. , Minazetdinova R. N.
Published: May 2022

The article highlights historic aspects of medical and research work for one of the prominent anesthesiologists ever – Virginia Apgar.
The role of platelets in antiviral immunity
Authors: Slukhanchuk E. V. , Bitsadze V. O. , Khizroeva J. Kh. , Solopova A. G. , Tsibizova V. I. , Yakubova F. , Ay C. , Gris J.-C. , Makatsariya A. D.
Published: May 2022

The main role of platelets is traditionally assigned to participation in hemostasis reactions. In recent years, the data have appeared on the non-hemostatic platelet-related role and their active participation in inflammatory reactions. These platelet functions are predetermined by their ability to activate and secrete various immunomodulatory cytokines and chemokines. In addition, activated platelets can directly interact with viral receptors. Recently, there has been growing the knowledge regarding platelet-related regulation of diverse cell types. The result of this interaction is, among others, the formation of platelet-leukocyte aggregates, the focusing of neutrophils at the sites of injury, and generation of a scaffold for developing extracellular traps. Thus, platelets are not only participants in coagulation processes, but also important players in the inflammatory process. This lecture details the issues of platelets controlling and modulating host response to viral infection, as well as potential targets for therapeutic intervention.
Personalized comprehensive rehabilitation program after surgical treatment of endometrial cancer: results of a prospective randomized comparative study
Authors: Sandzhieva L. N. , Solopova A. G. , Blinov D. V. , Son E. A. , Galkin V. N. , Alekseev A. B.
Published: May 2022

Aim: to evaluate effectiveness of a personalized comprehensive rehabilitation program in patients after surgical treatment of endometrial cancer (EC).

Material and Methods. There were enrolled 61 patients of reproductive age (44.46 ± 3.84 years) after radical treatment of endometrioid adenocarcinoma by stratifying subjects into 2 groups: group I – «active» rehabilitation with a comprehensive program of restorative measures (n = 29), group II – «passive» rehabilitation with standard management of the postoperative period in accordance with volume and timeframe determined by clinical recommendations (n = 32). Quality of life (QоL) was determined using the following questionnaires: Functional Assessment of Cancer Therapy for Patients with Endometrial Cancer (FACT-En), Kupperman-Uvarova Modified Menopausal Index (MMI), The Female Sexual Function Index (FSFI), Hospital Anxiety and Depression Scale (HADS). The program was based on four patient visits expected to occur at week 1 as well as 3, 6, 12 months after surgery, respectively.

Results. In was found that 12 months post-surgery MMI in group I was decreased from 40.75 ± 5.69 down to 26.45 ± 4.84 score corresponding to mild postovariectomy syndrome (POES), whereas in group II – from 39.62 ± 5.37 to 36.15 ± 4.06 score estimated as moderate POES. In addition, at this time point patients in group I were noted to virtually fully recover sexual function assessed by FSFI (24.93 ± 2.86 score), whereas in group II it was at markedly lower level (13.39 ± 2.55 score; p < 0.001). According to the HADS, all subjects had level exceeding score of 11 at week 1 post-surgery corresponding to clinically significant anxiety and depression. Moreover, 6- and 12-months post-surgery subjects in group I lacked significant symptoms (score < 7 for each parameter), whereas in group II 12-month follow-up demonstrated subclinical level of anxiety and depression. According to the FACT-En, subjects in group I vs. group II revealed markedly higher QoL on visit 4 reaching 141.31 ± 6.45 and 112.84 ± 6.48 score, respectively.

Conclusion. The «active» personalized comprehensive rehabilitation program proposed here demonstrated high efficacy in EC patients after radical surgery compared to subjects underwent standard management in rehabilitation period. Use of the program during 12 months post-surgery allowed to minimize negative manifestations related to POES, positively impacted psycho-emotional status, significantly improved sexual function as well as QoL. Organizing comprehensive rehabilitation in post-surgical EC patients should be considered as one of high-priority approaches in public healthcare.
Academician A.D. Makatsariya – Adjunct Professor of the University of Vienna
Authors: Editorial Article
Published: May 2022

Alexander Davidovich Makatsaria – obstetrician-gynecologist and world-renowned specialist in clinical hemostasiology, Professor, Doctor of Medical Sciences, Academician of the Russian Academy of Sciences, Vice-president of the Russian Society of Obstetricians and Gynecologists is an Adjunct Professor of the University of Vienna (Austria). In March 2022, the Rector's Office and the Academic Council of the Medical University of Vienna extended the powers of A.D. Makatsariya until 2025.