bluuebunny/crossref_metadata_2025 huggingface dataset:
Physical reservoir application of random network of gold nanoparticles fabricated by multi-step immersion in gold colloidal solution
Authors: Kobayashi Kaito , Shimada Hiroshi , Mizugaki Yoshinao
Published: May 2024

We fabricated a random network of gold nanoparticles (RN-GNPs) over 12 NiCr/Au electrodes by using a multi-step immersion method, where a sample was immersed in a gold colloid solution three times. Nonlinear current–voltage characteristics due to the Coulomb blockade were observed at 77 K. For demonstration of physical reservoir applications, input–output characteristics of the RN-GNPs were also measured in a one-input, nine-output terminal configuration. Distorted output voltage waveforms were obtained for a sinusoidal voltage input of 100 Hz. The higher-order harmonic components were confirmed in the frequency spectra of the outputs. The waveform reconstruction task and short-term storage capacity estimation were performed by an echo state network model with ridge regression and linear regression, respectively.
Identification of Curvularia eragrostidis (Henn.) J.A.Mey. the Leaf Spot Pathogen of Oil Palm (Elaeis guineensis Jacq.) and It’s Control by False Elder (Peronema canescens Jack) Leaf Extract
Authors: Febriani Anya Via , Kasiamdari Rina Sri
Published: May 2024

Oil palm is the main vegetable oil-producing crop in Indonesia. Leaf spot disease is one of the major diseases that attacks oil palm seedlings at all seedling stages. In Indonesia, leaf spot disease in oil palm nurseries is most commonly caused by the genus Curvularia with an infection intensity of up to 60–70%. The control of leaf spot disease usually uses chemical fungicides but its continuous use can cause the development of resistant pathogen fungi and have a long-term negative impact on the environment. False elder (Peronema canescens Jack) leaves have bioactivity as an antimicrobial control disease caused by fungal infections. In this study, Curvularia was isolated from oil palm seedlings infected with leaf spot disease from oil palm nurseries in South Sumatra. Effectiveness testing of P. canescens leaves conducted by a Completely Randomized Design method with five treatments and three replications. The fungi that caused leaf spot disease in oil palm were identified as Curvularia eragrostidis. P. canescens leaf water extract at 25% concentration was very ineffective to quite effective in controlling disease severity based on the average number of spots and diameter of spots in oil palm with the values 36.25–59.50% and 12.50–27.78%. P. canescens leaf water extract could reduce the average number of spots and diameter of spots started on day 30 after being sprayed three times with P. canescens leaf water extract so that it could be used as an alternative to control C. eragrostidis leaf spot disease in oil palm that is more friendly to the environment.
PROSPECTS AND POSSIBILITIES OF CONSTRUCTION OF BRIDGES WITH A REDUCED NUMBER OF SUPPORTS ON UKRAINE ROADS USING MODERN TECHNOLOGIES
Authors:   State Enterprise «National Institute of Infrastructure Development» (SE «NIDI»), Kyiv, Ukraine, Veretelnikov Oleh , Ostapchuk Vitalii ,   State Enterprise «National Institute of Infrastructure Development» (SE «NIDI»), Kyiv, Ukraine
Published: May 2024

A certain number of urban overpasses in Ukraine were built in the 1950s and 1960s with short spans and a large number of intermediate piers (e.g., Beresteyskyi overpass in Kyiv). The presence of intermediate piers on the roadway creates an emergency situation due to the disappearing lane before entering the structure on both sides, which leads to the accumulation of cars during rush hour. Such overpasses require reconstruction, which should include a reduction in the number of intermediate piers. As part of pre-design surveys during the reconstruction or construction of new overpasses, it is advisable to conduct laser scanning of the surrounding area to ensure the most accurate reflection of the existing infrastructure, harmonious interaction of the structure with the terrain, optimization of earthworks and use of construction materials. The use of laser scanning is a modern way to control construction and is in demand around the world. Introduction. This article reveals the need to reconstruct urban overpasses with a large number of intermediate piers to avoid the formation of accident-prone areas at the entrances to the structure. Urban bridges and overpasses require a special approach to their design and construction, as in these conditions it is recommended to take into account the aesthetic component, which includes architecturally expressive design solutions. The article presents proposals for the design of such an overpass using laser 3D scanning, which allows for a more detailed study of the design site and simplifies the control of construction work. Problem statement. The presence of intermediate piers on the roadway under overpasses creates an emergency situation due to the disappearing lane, as well as the accumulation of cars during rush hour.
THORACOSCOPIC THYMECTOMY FOR STAGE-1 THYMOMA WITH MYASTHENIA GRAVIS USING LEFT-SIDED THREE-PORTAL APPROACH
Authors: Sharma Harish , Mittal Deepak , Saini Sanjay , Mittal Deepesh
Published: May 2024

Thymoma is a rare tumor of thymic epithelial cells, often found in association with myasthenia gravis. Surgical resection
is the treatment of choice for thymoma, and thoracoscopic thymectomy is a minimally invasive approach that has shown
comparable outcomes to open thymectomy. Thoracoscopic thymectomy for thymoma with myasthenia gravis is a safe and effective surgical
technique. It allows for complete resection of the tumor while minimizing postoperative complications. This approach provides excellent
visualization and access to the thymus and surrounding structures, allowing for precise dissection and tumor removal. Additionally, the use of
thoracoscopy reduces postoperative pain and shortens hospital stays compared to open thymectomy. Our case report details the successful use of
the left-sided three-portal approach for thoracoscopic thymectomy in a patient with stage-1 thymoma and myasthenia gravis. The minimally
invasive nature of this surgical technique not only allowed for complete resection of the tumor but also contributed to a reduction in postoperative
pain and shorter hospital stays for the patient. The excellent visualization and access to the thymus and surrounding structures provided by this
approach facilitated precise dissection and tumor removal, resulting in favorable outcomes for the patient.
PLAY SKILLS AND DEVELOPMENTAL TRAJECTORY IN PRESCHOOL CHILDREN WITH MILD TO MODERATE AUTISM SPECTRUM DISORDERS
Authors: Jaywant Shailaja , Ganesh Tushika , Varadkar Hrucha Samir , Maruti Ghode Ashwini , Ingale Priya
Published: May 2024

Autism Spectrum Disorder (ASD) is characterized by decits in social interaction, impaired communication abilities,
restricted and repetitive behaviors and reduced interest and engagement in social activities, all of which impact their
developmental and play skills. The purpose of this study was to observe the play skills and developmental trajectory, as well as to explore their
correlation, among children diagnosed with mild to moderate ASD.
The play abilities of twenty preschool children, with ages ranging from 2 to 6 years, who have been diagnosed with mild to moderate Autism
Spectrum Disorder, were assessed using the Knox Preschool Play scale. The assessment of developmental trajectory was conducted utilizing the
Ages & Stages Questionnaire-III (ASQIII). The relationship between them was examined through the application of the Pearson correlation test.
The play skills affected to moderate level scores ranging from -0.47 to 0.75 out of maximum score 2 and the developmental domains such as
communication, ne motor skills, problem solving abilities & personal social development showed moderate to severe involvement scoring
between 8.75 to 28.36 out of maximum score of 60 in each domain.
Space and Material Management displayed a moderate level of impairment. There is a notable impairment in both participation and
pretense/symbolic play. The impact on the development of personal social skills and problem-solving abilities was notable when compared to
children with typical development. This suggests a deviation from the usual trajectory of overall development and play capabilities. Researchers
have noted a moderate positive correlation between material management and the development of both ne motor skills and problem-solving
ability. Participation has been observed to exhibit a similar correlation with ne motor skills. The signicance of executive functions, planning,
and ne motor development in the development of play skills is emphasized by these ndings, suggesting the necessity of Occupational Therapy
intervention for child development.
PREOPERATIVE SERUM ALBUMIN LEVEL AS A PREDICTOR OF ABDOMINAL WOUND-RELATED COMPLICATIONS AFTER EMERGENCY EXPLORATORY LAPAROTOMY
Authors: Vardhan Apoorva , Kumar Narra Sandeep , S Vinayaka , R Deepthi.
Published: May 2024

Introduction: A plethora of factors are involved in the process of wound healing; amongst them nutritional status of the
patient is highly considered for fast recovery in the postoperative period. Literature shows that preoperative serum
albumin levels can determine & impact postoperative complications in patients undergoing emergency laparotomy. Therefore, early detection &
intervention is highly recommended. A retrospective study data consisting of 69 patients collected o Methods: ver 8 months amongst those who
underwent emergency exploratory laparotomy due to perforation and small and large bowel obstruction was collected. Preoperative serum
albumin levels & postoperative complications such as delayed wound healing (>7 days), surgical site infections on 5th day, anastomotic leak,
enterocutaneous stula (>7 days), wound dehiscence and prolonged hospital stay (>5 days) were noted & analysed statistically. (P<0.001)
Results: Majority of the subjects were in the age group of 18-29 years accounting for 30.4% with 63.8% being males. Also, 68.1% patients had
albumin levels >3.5g/dl. The mean duration of hospital stay & duration of surgery was found to be 14.11 days & 175.51 mins respectively. The
most common procedures performed were primary closure (32%) & resection anastomosis (52.2%). Patients with <3.5g/dl reported
complications such as death (4), surgical site infection (21), anastomic leak (2), enterocutaneous stula (2), and increased hospital stay (1).
Conclusion: Preoperative serum albumin levels can be used to determine & reduce complications in the postoperative period while reducing the
morbidity and mortality levels by early intervention
STUDY OF ORGAN SYSTEM INVOLVEMENT IN SEVERE DENGUE FEVER CASES ADMITTED TO A TERTIARY HEALTH CARE CENTRE
Authors: Siwach Rahul , Arora Aditi , Beniwal Karan
Published: May 2024

Objective:1. To study the clinical prole & laboratory diagnostic ndings in severe Dengue fever cases.
2. To compare the pattern of organ involvement with severe Dengue Fever (DF) cases admitted in 2023-2024.
Materials and Methods: This Descriptive Longitudinal Study, conducted at a tertiary care center in India, focused on severe dengue cases
admitted between January 2023 and May 2024. Group A comprised 54 patients, where detailed history-taking and clinical examinations were
performed to evaluate severity and complications. Data analysis encompassed the period from January 2023 to May 2024 for Group A.
Comparison was made with Group B, consisting of 53 severe dengue cases from 2021-2022, to assess the pattern of organ involvement using
identical inclusion and exclusion criteria. Informed consent was obtained from patients or relatives, with data collection conducted via
structured clinical Performa. Routine and special investigations were carried out, including NS1Ag and IgM Dengue detection using
government-supplied kits. Both Group A and Group B showed a male predominance (61% and 68% respectiv Results: ely) and were primarily
aged 18 to 30 years (70% and 60% respectively). While presenting symptoms were similar, Group A exhibited higher prevalence of cough,
difculty breathing, convulsions, and petechiae. Hemorrhagic manifestations were more frequent in Group A (40%). Thrombocytopenia was
universal, with 72% of Group A and 78% of Group B cases having platelet counts below 50,000 /cu mm. Elevated SGOT and SGPT levels were
seen in 13% and 6% of Group A cases respectively. Pleural effusion and acute respiratory distress syndrome (ARDS) were more common in
Group A on chest X-ray. Dengue hemorrhagic fever (DHF) I was more prevalent in Group B (72%), while DHF II-IV were more common in
Group A. Complications such as coagulopathy, acute renal failure, ARDS, and hepatitis were more frequent in Group A. The mortality rate was
higher in Group A (9%) compared to Group B (6%). In summary, our study underscores the wide range of Conclusions: symptoms and
complications seen in severe dengue cases, from mild fever to life-threatening organ failure. We noted a higher occurrence among young adult
males aged 18-30. Between 2023-2024, there was a rise in severe complications such as serositis, thrombocytopenia, and hepatic, respiratory,
renal, and neurological issues. Dengue shock syndrome and hemorrhagic fever had notably higher mortality rates during this period,
emphasizing the importance of vigilant management to address severe dengue infections effectively
AN OVERVIEW ON CLOUD COMPUTING
Authors: Muthurasu C. , Suganthi M.
Published: May 2024

The study was examined the general overview of cloud computing is given in this paper. The integration of businesses or
libraries is made simple by cloud computing. Cloud computing provides multiple services that are user-centered. The
majority of libraries today use cloud computing technologies to manage their digital collections and social media with a variety of customization
options. This document discusses a variety of cloud computing needs, service models, and types of cloud storage, advantages and disadvantages.
In the history of services provided by way of the internet, cloud computing is a relatively new phenomenon. No matter where you are in the world,
it has fundamentally altered how you use computer power. The fact that it uses platforms, hardware, or software from outside sources to provide
services is the advantage that organizations and businesses can most clearly see. It is incredibly cost-effective because it requires fewer
investments and money. Cloud computing is available in a variety of formats.
ARTHROGRYPOSIS MULTIPLES CONGENITA-A CASE REPORT.
Authors: Ahammad S Imtyaz , Amreen Shaik Neha
Published: May 2024

Arthrogryposis Multiplex Congenita is a rare sporadic nonprogressive
congenital disorder characterised by multiplejoint contractures and
can incorporate muscle weakness and brosis.
PRE-OPERATIVE NEUTROPHIL-LYMPHOCYTE RATIO TO PREDICT OUTCOMES IN ELECTIVE LAPAROSCOPIC CHOLECYSTECTOMY
Authors: K. Aithal Srikanth , Ramani Kadambari
Published: May 2024

Background: Many scoring systems exist to predict operative difculty and outcomes of laparoscopic cholecystectomy
in acute cholecystitis. In elective laparoscopy where ambulatory/ outpatient surgery is considered, few studies are
available. Neutrophil-lymphocyte ratio (NLR) can be used as an effective pre-operative predictive marker in elective laparoscopic
cholecystectomy. A single center prospective observational study was done over a period of one year Materials and Methods: in 72 patients
undergoing elective laparoscopic cholecystectomy. Only those patients with predicted easy/ moderate laparoscopic cholecystectomy were
included. NLR ≥ 3 was considered high. Intraoperative and postoperative outcomes were studied in normal and high NLR patients. Results:
Normal neutrophil-lymphocyte ratio (NLR) was noted in 46 patients (63.9%) and high NLR (≥ 3) in 26 patients (36.1%). Rates of previous
cholecystitis/ cholangitis and ERCP with stenting were similar in both groups. Mean G10 intra-operative score was 1.98 (easy group) in normal
NLR group vs 3 (moderate group) in high NLR group (p <0.05). None of the patients who participated in the study needed conversion to open
procedure or had adverse intra-operative outcomes. Post-operatively, patients with normal NLR had signicantly low pain score at day 1
compared to high NLR group (1.91 vs 4.5; p <0.001). Patients with high NLR also had signicantly increased length of hospital stay (1.19 days in
normal NLR vs 2.77 days in high NLR, p <0.001). Positive predictive value (PPV) of high NLR in estimating hospitalization post-surgery of
more than 1 day is 92.3%. Pre-operative NLR can be used as a cost-effective and useful tool in pred Conclusion: icting outcomes in elective
laparoscopic cholecystectomy, even in carefully selected group of patients. In settings of outpatient cholecystectomy, this will help in decision
making and patient selection.
EPIDERMOID CYST IN UTERINE CERVIX- A RARE AND UNUSUAL LOCATION
Authors: Naaz Farha , Fatima Asfiya , Afroze Idrees Akhtar
Published: May 2024

Cervical epidermoid cysts and uncommon benign cystic lesions were identied in a 50-year-old woman. The patient
presented with heavy menstrual bleeding and lower abdominal pain, and after initial treatment with endometrial biopsy
and hemostatic uterine curettage, a total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. The gross examination of
the specimen revealed a hypertrophied cervix with a cyst lled with grey-white substance, as well as a polypoidal mass in the fundus and
intramural broids. Histopathological examination conrmed the diagnosis of a cervical epidermoid cyst as an incidental nding. Squamous
metaplasia was conned to the cervical mucosa. The precise etiology remains unclear, but post-parturient implantation of vestigial embryonic
tissue might be a contributing factor as there is no other associated etiology in this case. This case report emphasizes the importance of considering
epidermoid cysts in the differential diagnosis of cervical masses and highlights the need for further research to better understand the formation and
management of these rare cysts.
NEUROCUTANEOUS MELANOSIS IN A NEWBORN – A CASE REPORT.
Authors: Shalu BI Dudekula , Irfani Shaik
Published: May 2024

Neurocutaneous melanosis (NCM) is known as a rare phakomatosis
characterized by large or numerous pigmented congenital nevi
associated with leptomeninges melanin containing deposits. NCM can
be asymptomatic or present as variably severe and neurological
impairment sometimes resulting in death. Prevalence is estimated at
1/50,000 –1/200000.The incidence of symptomatic NCM appears to
be approximately a third to half of these
Een plek om mens te blijven. Onderwijs voor een ongekende toekomst (deel 2)
Authors: de Vrieze Govert-Jan
Published: May 2024

In het eerste deel van dit drieluik schreef ik dat we niet vaker in de geschiedenis van de mens voor grotere uitdagingen hebben gestaan (de Vrieze 2023). Klimaatverandering, verlies van biodiversiteit, pandemieën, groeiende economische ongelijkheid, polarisatie en migratie zorgen met allerlei andere factoren tot een polycrisis van ongekende omvang (Homer-Dixon et al. 2022). Maar het zijn vooral onze kinderen en kleinkinderen die zich daartoe zullen moeten verhouden: ‘Confronting our predicament means facing head-on the oftavoided and grim fact that our children and grandchildren, and their descendants down the line, will be dealing with the ramifications of the Anthropocene for decades and centuries to come.’ (Schenck en Churchill, 2021, p.497) Daarna stelde ik de vraag wat ons in het onderwijs te doen staat gegeven deze onzekere en overweldigende toekomst. Wat betekent het voor leraren, schoolleiders, voor het onderwijs aan een nieuwe generatie?
De stem van de natuur
Authors: Rosa Hartmut
Published: May 2024

Het idee dat de kosmos (tot ons) spreekt of zelfs zingt, is zeker niet alleen een religieus of mythisch, premodern idee. Het oude, vooral Pythagoreïsche, idee van een muziek der sferen die voortkomt uit de bewegingen van de sterren en in het bijzonder van de planeten, is geformuleerd in allerlei variaties en werd bijvoorbeeld door Johannes Kepler overgedragen naar de moderne, heliocentrische kijk op de wereld in zijn vijfdelige werk over ‘Wereldharmonieën’ (harmonices mundi). De wetten van de astronomie, zo meende Kepler te kunnen aantonen, komen overeen met de wetten van de muziek – beide zijn gebaseerd op resonanties. En in de huidige interpretaties van de snaartheorie als een hedendaagse poging om deeltjesfysica en astrofysica te combineren, worden de kosmische snaren niet toevallig vergeleken met de snaren van een muziekinstrument. Zo schrikt natuurkundige Brian Greene, die doceert aan Columbia University, er in zijn wereldbestseller The Elegant Universe niet voor terug om deel drie van zijn boek ‘The Cosmic Symphony’ te noemen en te verklaren dat de basis van de superstringtheorie ‘niets anders dan muziek’ is.
Hoe zinnig is het meten van zingeving?
Authors: Molenaar Brecht
Published: May 2024

Op 10 oktober 2023 had de ZonMw-programmacommissie ‘Zingeving en Geestelijke verzorging’ op verzoek van het ministerie van VWS een debat georganiseerd over de vraag: het meten van effecten van geestelijke verzorging en aandacht voor zingeving – is dit zinvol? In het programmablad stond dat het debat ging over het nut, de noodzaak en de haalbaarheid van het meetbaar maken van aandacht voor zingeving en geestelijke verzorging. Het Zon- Mw-verslag kreeg kortweg als titel: hoe zinnig is het meten van zingeving? Je leest daarin ook hoe de dagvoorzitter de kwestie had beschreven: of, en zo ja, hoe er met behulp van onderzoek kan worden aangetoond dat aandacht voor zingeving en het bieden van geestelijke verzorging waardevol is. Ik neem die laatste formulering als uitgangspunt voor deze tekst. Er stonden 2 ½ uur voor het debat. Er waren zes sprekers met ieder een kwartier. Hierdoor bleef er voor het eigenlijke debat relatief weinig tijd over. Toen mij als deelnemer kort daarna de mogelijkheid werd geboden alsnog schriftelijk te reageren, ben ik daar dan ook direct op ingegaan. Ik schreef een notitie die later aan de basis is komen te liggen van dit artikel. Ik schrijf dit artikel vanuit mijn positie als geestelijk verzorger (voortaan afgekort tot gv’er) met een zending van het Humanistisch Verbond en als zorgethica. Tijdens het schrijven heb ik een hele ontwikkeling in mijn denken doorgemaakt. Doordat ik de standpunten van de sprekers nog eens goed bestudeerde, kwam ik erachter dat die genuanceerder waren dan hoe ik het had beleefd tijdens het debat. Het bleek althans wel mee te vallen met het enthousiasme voor effectmetingen, een idee waar ik zelf allerlei bedenkingen bij heb. Niettemin bleef ik een zeer ongemakkelijk gevoel houden. Het heeft me veel hoofdbrekens gekost om de vinger op de zere plek te leggen. Volgens mij was dat zo lastig doordat mijn ongemak wringt met het heersende discours over geestelijke verzorging en zingeving. Het ‘zingevingsdiscours’, zoals ik dat noem, is inmiddels zo algemeen geaccepteerd en lijkt zo vanzelfsprekend dat ook ik er alleen maar tegenin kan denken wanneer ik goed voeling blijf houden met wat feitelijke zorgpraktijken, ook die van mezelf, mij laten zien.
Analisis Performa Homestay Desa Wisata untuk Mewujudkan Standarisasi di Kabupaten Kulon Progo
Authors: Wijayanti Ani , Dewi Ike Janita
Published: May 2024

Homestay is one of the mandatory accommodations in a tourist village. Optimal homestay management is a guide for every tourist to get comfort during their stay. This study aims to examine the performance of homestays in the tourist village of Kulon Progo through three variables: product, service and management. This study used a quantitative descriptive approach, with scoring and reduction data analysis techniques. The research samples were 11 tourist villages in Kulon Progo. Purposive sampling technique was used to select tourist villages based on their categories. The results showed two homestay class categories, namely classes 1 and 2. Product variables have the highest performance, while service and management have almost the same performance and are still relatively low. Performance indicators that are considered to be still low, namely digital-based services and administration. The performance of the homestay is often not in line with the classification of tourist villages. The survey results show advanced tourism villages have lower homestay performance than the pioneer and developing tourism villages. The research implication provides an overview of homestay performance in Kulonprogo as a reference in improving homestay standardization.
Glass Elevator at Kelingking Beach: A Comparative SWOT Analysis of Infrastructural Innovations in Tourist Destinations
Authors: Suhardono Sapta , Suryawan I Wayan Koko
Published: May 2024

This study undertakes a SWOT (Strengths, Weaknesses, Opportunities, Threats) analysis of the proposed glass elevator installation at Kelingking Beach, a renowned tourist destination in Bali. The research draws upon diverse scholarly perspectives to offer a comparative lens on infrastructural developments in natural settings. While the glass elevator promises to democratize access, particularly for older people and those with mobility challenges, and possibly amplify economic gains, it also brings forth concerns related to overdevelopment, environmental impact, and the risk of compromising the intrinsic charm of the destination. Our findings elucidate that while there are clear strengths, such as enhanced accessibility and potential for premium pricing, there are notable challenges to consider. The weaknesses, primarily arising from potential safety concerns and the possibility of detracting from the beach's natural allure, call for thoughtful solutions. Opportunities present themselves through collaborative efforts, sustainable practices, and a reinvigorated tourism sector. The study serves as a template for policymakers and stakeholders in natural tourist destinations, aiming to integrate infrastructure without diluting the essence of the locale.
PENGARUH KECERDASAN INTERPERSONAL, ENERGI TINGKAT TINGGI DAN TANGGUNG JAWAB OWNER TERHADAP KINERJA USAHA UMKM
Authors: Junedi Junedi , Gopar Ida Abdul , Handayani Langgeng Sri
Published: May 2024

Penelitian ini bertujuan untuk menganalisis pengaruh kecerdasan interpersonal, energi tingkat tinggi, dan tanggung jawab pemilik (owner) terhadap kinerja usaha pada Usaha Mikro, Kecil, dan Menengah (UMKM). Pendekatan kuantitatif digunakan dalam penelitian ini dengan menggunakan kuesioner sebagai alat pengumpulan data. Sampel penelitian ini yaitu sejumlah 80 pemilik UMKM yang beroperasi di wilayah Bekasi. Analisis uji validitas-reliabilitas, uji asumsi klasik serta analisis regresi untuk mengukur hubungan antar variabel digunakan untuk menganalisis data yang terkumpul. Hasil penelitian menunjukkan adanya pengaruh signifikan: 1).Kecerdasan Interpersonal (KI), 2).Energi Tingkat Tinggi (ETT) dan 3).Tanggung Jawab Owner (TJO) terhadap Kinerja Usaha dengan persamaan regresi KU=5,403+0,515KI+0,110ETT+0,273TJO. Kecerdasan interpersonal yang tinggi memungkinkan pemilik UMKM membangun hubungan yang baik dengan pelanggan, supplier, dan mitra bisnis lainnya, sehingga meningkatkan kinerja usaha. Energi tingkat tinggi memperkuat kemampuan pemilik UMKM dalam menghadapi tantangan dan mengambil peluang yang ada, sehingga berdampak positif pada kinerja usaha. Tanggung jawab owner berperan penting dalam memastikan kelancaran operasional dan pertumbuhan bisnis UMKM.
Extra Virgin Olive Oil Mitigated Uterine Dysfunctions in Female Wistar Rats Exposed to Benzene and Ethanol
Authors: Adebola Adetunji Opeyemi , Olufunso Adeoye Bayo , Ezekiel Adeogun Adetomiwa , Philips Akano Oyedayo , Bangsi Achor Corniluis , Chigbogu Nwobi Joseph , David Adeoye Ayodeji , Linda Nwobi Nnenna , Barak Adebayo
Published: May 2024

Background: Exposure to benzene and ethanol is known to predispose to ovarian and uterine retardation, Extra virgin olive oil (EVOO) is an essential oil that is well-reputed for its outstanding nutraceutical and therapeutic properties. The present study is aimed at elucidating the pharmacological potentials of EVOO supplementation on ethanol/benzene-induced female reproductive dysfunctions in rats. Methodology: Forty-eight (48) adult Wistar rats weighing (110kg-130kg) were divided into 8 groups (n = 6). CTR= Control, EVOO= Extra Virgin Olive Oil, ETH= Ethanol, BEN= Benzene, ETH+BEN= Ethanol + Benzene, ETH+EVOO= Ethanol+ Extra Virgin Olive Oil, BEN+EVOO= Benzene+ Extra Virgin Olive Oil, ETH+BEN+EVOO= Ethanol+Benzene + Extra Virgin Olive Oil. They were administered Ethanol, Benzene and Extra Virgin Olive Oil according to the grouped tagging. At the end of the experiment, the rats were sacrificed while tissues were harvested, and processed for H & E stain and Masson Trichrome stain histopathological assessment. Progesterone and estradiol were measured using standard methods. Statistical analysis was done using Analysis of Variance (ANOVA) on GraphPad Prism 5.0 software. Significance was set at p<0.05. Results: Interestingly, EVOO supplementation significantly (p<0.05) increased body weight, estradiol, and progesterone levels, while also mitigating ovarian and uterine histoarchitectural integrity. Conclusion: EVOO may be considered when formulating a dietary regimen in the management of female reproductive dysfunctions associated with benzene and ethanol.
INNOVATIVE APPROACHES TO PREVENTION POULTRY SALMONELLOSIS
Authors: Avdosieva I. K. , Chaikovska O. I. , Kolodiy H. V.
Published: May 2024

Among food-borne toxic infections of humans, salmonellosis ranks second after campylobacteriosis. In Ukraine, in accordance with the order of the Ministry of Food and Agriculture of September 19, 2016 No. 310, an instruction on the prevention and elimination of poultry salmonellosis was developed and approved, which provides for the monitoring and control of salmonellosis infections. Preliminary diagnosis is made on the basis of clinical and epizootological data and patho-anatomical changes in organs and tissues. Positive serological reactions can be of decisive importance for confirming the presence of infection in the herd, however, they are not sufficient for making a diagnosis due to the possibility of cross-reactions with other Salmonella. The final diagnosis can be made only after isolation and identification of the culture of the causative agent.
As one of the elements of the fight against salmonellosis, prophylactic vaccination of poultry is used. Inactivated and live vaccines have been proposed for this purpose. Immuno-prophylaxis allows to reduce the possibility of vertical and horizontal transmission of salmonella and the level of spread of microorganisms in the environment. Vaccination can reduce the degree of clinical manifestation of the disease, mortality and invasion of the pathogen in various organs, but does not prevent the infection of the bird. In Ukraine, vaccination against poultry salmonellosis is an additional measure of infection prevention and elimination. The basis for the introduction of mandatory vaccination is the presence of this infection in more than 10% of farms (according to the generalized data of laboratory studies). Vaccination is carried out in accordance with Commission Regulation CR (EC) No. 1177/2006. 3 for the specific prevention of salmonellosis, inactivated and live vaccines, DNA vaccines, subunit vaccines, etc. are used. More than 20 commercial vaccines against poultry salmonellosis have been registered in the world. 11 vaccines are registered on the market in Ukraine, of which 1 is a preparation of a domestic manufacturer.
For the prevention of salmonellosis infection in poultry farming, it is necessary to use a systematic approach, which involves the implementation of veterinary and sanitary measures to prevent the introduction of pathogens of infectious diseases into the farm, including monitoring and diagnostic studies throughout the entire technological chain of production, the use of effective drugs specific and at critical control points (НАССР) in order to ensure the absence of salmonella in the parent flock of poultry, in feed and in water. The system of effective control of epizootic welfare in relation to poultry salmonellosis involves the use of specific preventive measures that ensure long-term and reliable protection of poultry from infection and systematic microbiological monitoring of the spread of salmonella.
COLD INHIBITION OF BIOACTIVITY OF PROBIOTIC MYCOBACTERIA AND AEROCOCCI IN THE MICROBIOME
Authors: Zazharskyi V. V. , Sosnytska A. O. , Paliy A. P. , Biben I. A.
Published: May 2024

The organism of farm animals is constantly under the influence of various factors of the external environment, and one of the negative factors of violation of the technology of keeping and creation of unsatisfactory conditions of existence with deterioration of well-being is cold injury. Mostly it manifests itself as a permanent effect of positive temperatures well below the physiological norm or periodic fluctuations of an uncomfortable temperature. Such a stress factor of low intensity, but permanent over a long period of time, causes negative pathophysiological changes in the macroorganism with the development of immune-depression, metabolic syndrome, perversions of the qualitative composition of the microbiome and, as a result, disruption of native physiological processes of stimulation of cellular mechanisms of nonspecific innate immunity, induced by immune-biological mechanisms of the functioning of neutrophil granulocytes. The negative effect of low-intensity permanent cold stress was studied on a model object - murchakаs, which were kept for two weeks at a temperature of 4-6 °C under conditions of light and movement restriction. Before the start of the experiment, initial microbiological studies of the microbiome of the large intestine were conducted using generally accepted methods. Resident indigenous probiotic prokaryotes - M. vaccae & A. viridans, which possessed typical species characteristics, were isolated. Pathogenic variants of enterobacteria were not isolated, isolated cultures of E. coli were apathogenic and belonged to the usual normal flora. A two-week cold injury resulted in the disappearance of the indigenous probiotic microbiota M. vaccae & A. viridans, which are indicator prokaryotes of the physiological well-being of the macroorganism, from the microbiome. At the same time, the number of potentially pathogenic enteral microorganisms, coccal and rod-shaped, increased. This was correlated with a decrease in the phagocytic activity of native neutrophil granulocytes and their preformed filamentous spatial nucleoprotective mesh structures, which inhibit the de-fragmentary function in relation to genetically non-syngenic objects.
INFLUENCE OF FEED ADDITIVE "ENZAKTIVE MIX" ON THE HEMATOLOGICAL PROFILE OF THE BLOOD OF SOWS AND THEIR PIGLETS
Authors: Prudyus T. , Broda N.
Published: May 2024

The dynamics of the haematological profile changes and the productivity of sows and piglets obtained from them when feeding the feed additive "EnzActive Mix" were described in the article. The feed additive contains yeast of the genus Saccharomyces cerevisiae with an activity of at least 1.5 x 10^10 CFU/g and a six enzymes complex with protease, cellulase, xylanase, ɑ-amylase, β-gluconase, phytase, which are located under the layer of yeast cells.
The results of the study showed that the use of "EnzActive Mix" in sows and their piglets’ diet has a stimulating effect on the oxygen transport function of blood. This is evidenced by a higher number of erythrocytes and platelets, a higher concentration of haemoglobin and haematocrit in the blood of sows of the experimental group compared to the control group on 21st day of lactation (p<0.05). Addition of the feed additive "EnzActive Mix" to the diet caused changes in certain forms of leukocytes ratio in the sows’ blood. Thus, during this period, a higher (p<0.05) relative lymphocytes number and a tendency to decrease of segmented neutrophils number in the blood of experimental group sows compared to the control group were found.
  Similar changes were noted in the haematological parameters study of piglets obtained from these sows. In particular, the leukocytes number in the blood of the experimental group piglets at 5-, 14- and 28-day age was higher than in their peers of the control group. At the same time, on the 5th day of life, the differences relatively to the control group animals were significant (p<0.05). Feeding of the feed additive led to a decrease in the segmented neutrophils relative number in the blood of the experimental group piglets on the 14th and 28th day of life (p<0.05) and an increase in the lymphocytes number (p<0.05) during the indicated periods of the study.
The positive effect of the feed additive "EnzActive Mix" on the productivity parameters of the studied animals was established. In particular, the body weight of experimental group piglets at 5-, 14- and 28-day age was 7.8%, 13.7% (p<0.05) and 8.4% (p<0.01) higher, respectively, than that of the control group.
NOSOLOGICAL FEATURES OF INFECTIOUS ABORTIONS IN COWS
Authors: Radzyhovskyi M. L , Sachuk R. M. , Koshevoy V. I. , Dyshkant O. V. , Sokulskyi I. M. , Katsaraba O. A. , Kulishenko O. М. , Davydenko P. О. , Ruda M. E.
Published: May 2024

Providing the country's population with high-quality products is a priority task of modern animal husbandry. However, there are a number of problems in the industry that prevent obtaining quality products of animal origin in the required volume. The intensification of dairy farming and the increase in milk productivity of cows is often accompanied by a metabolic disorder, which reduces the body's resistance, contributing to the development of immune-deficiencies, which increase the susceptibility of animals to infectious diseases, some of which have an abortive form of manifestation and, accordingly, the consequence is a lack of offspring and potential income due to abortions. Abortion in cows should be considered not only as a gynecological problem, but also as an economic one, because animal husbandry accounts for more than 38% in the structure of gross agricultural products of the country and the lack of keeping of young animals significantly affects the development of the livestock industry.
This publication is devoted to the results of the nosological profile of infectious abortions in cows on the territory of Ukraine, among which 64% of cases are infectious agents - 41.4% of bacterial origin and 22.6% of viral origin. The most frequent factors of bacterial etiology of abortions in cows are leptospira, coxiella, salmonella, mycoplasma, campylobacter, chlamydia, toxoplasma and listeria, and the most common viral ones are flavo-virus, gamma-herpesvirus and alpha-herpesvirus.
EFFECT OF PROTEIN-VITAMIN MINERAL FEED ADDITIVE ON EXCHANGE PROCESSES IN THE ORGANISM OF REPAIR HEIFERS DURING THE GROWING PERIOD
Authors: Fedak N. , Sedilo G. , Chumachenko S. , Dushara I. , Mamchur О.
Published: May 2024

The results of the effect of a protein-vitamin mineral feed additive (PVMA) developed on the basis of extruded fodder beans, rapeseed, barley grain and macro- and microelements (Sulfur, Zinc, Cobalt, Iodine), vitamins (A, D) that are deficient for the western region on physiological and biochemical status, growth and development of repair heifers (0–6 months of age) during the transition to vegetable feed and the formation of a rumen type of digestion. Combined feed-starter, which was fed to heifers of the control group, included sunflower cake, barley, wheat, oat flour, dry skimmed milk, grass clippings, chalk, table salt and standard premix P 63-2-89. PVMFA was fed to the heifers of the research group as part of the combined feed-starter in quantity 40% by weight instead of 20% sunflower cake, twice a day, starting from 20 days of age. In addition, the heifers of the experimental group additionally received sodium humate at the rate of 20 mg/kg of live weight. It was found that in the rumen content of 3- and 6-month-old heifers of the experimental group, the number of amylolytic bacteria probably increased by 7.3% and 13.6%, respectively; at 6 months, a 10.5% higher concentration of cellulolytic microorganisms was noted, as well as 18.6% number of ciliates and a probable increase in the amount of RNA phosphorus compared to control analogues was noted. The introduction of the experimental variant of PVMFA into the combined fodder-starter of the heifers of the research group contributed to an increase of hemoglobin content in blood in the 3-month age by 3.13%, total lipids – by 14.3%, AST activity – by 11.43%. In 6 months age, there was an increase in total protein content by 6.0 (Р<0.001) and a decrease in the level of urea by 25.6% (Р<0.001) compared to the control. Feeding experimental PVMFA had a positive effect on live weight gain. The average daily gains of experimental animals amounted to 726 g and were 11.2% higher than those of control animals (653 g).
VARIABILITY OF SIGNS OF MILK PRODUCTIVITY OF COWS DEPENDING ON THEIR LINEAL AFFILIATION
Authors: Shpyt I. V. , Fedorovych V. V. , Kuziv N. M. , Chornyj I. O.
Published: May 2024

Data on the signs of milk productivity of cows of the Ukrainian Black-and-White dairy breed depending on their lineal affiliation are given. The research was conducted in SE DG "Oleksandrivske" Vinnytsia region (Forest-Steppe zone, n=714), the LLC JV "Imeni Volovikova" Rivne region (Polissya zone, n=1,840) and the SE "Experimental farm "Askaniyske" (Steppe zone, n=926 ) on firstborn and full-grown (III lactation) animals.
It was found that cows of the Chif line 1427381 (6384 kg) were the most productive in the first lactation in the Forest Steppe zone, in the third - Eleveishn line 1491007 (7325), in the Polissya zone – Starbak line 352790 for both lactations (6126 and 6521 kg, respectively), and in the Steppe zone – Annas Adema 30587 lines (6570 kg and 7482 kg). The highest content of fat in the milk of the SE DG "Oleksandrivske" was found in the first-borns of the Valiant line 1650414 (3.65%) and in full-aged cows of the Starbak line 352790 (3.59%), in the LLC JV "Imeni Volovikova" – Eleveyshn 1491007 (3.67 %) and Valiant 1650414 (3.68%), in SE "Experimental farm "Askaniyske" – Chif 1427381 (4.19%) and Bell 1667366 (4.19%).
It is worth noting that the lowest milk yield for the first lactation in the above-mentioned farms was observed, respectively, in cows of lines Haneve 1629391 (5465 kg), Valiant 1650414 (4545 kg) and Bell 1667366 (6055 kg), for the third lactation - in individuals of lines Valiant 1650414 (6633 kg), Eleveishn 1491007 (6058 kg) and Bella 1667366 (6464 kg). In the Forest Steppe zone, the first-borns of the Eleveyshn 1491007 and Starbak 352790 lines were the least fat-milk – 3.59%, and full-aged cows of the Chif 1427381 and Valiant 1650414 lines – 3.56%, in the Polissya zone – the Chif 1427381 and Starbak 352 lines – 3.62% 790 – 3, 62%, and in the Steppe zone – the Annas Adem 30587 line for both lactations – 3.95 and 3.89%, respectively.
Variance analysis confirmed the conditionality of the phenotypic variability of the quantitative traits of milk production depending on the lineal belonging of cows established by the comparison of group averages. At the same time, the line had a more significant effect on hope than on fat. Depending on the farm and lactation, the strength of the influence on the milk fat content was in the range of 4.1–21.1%, and in the range of .4–12.4%.
Therefore, the linear belonging of cows to some extent can serve as a criterion for predicting their milk productivity.
Reduction in Healthcare Resource Utilization Following Treatment With a Home-Based Footworn Device in Patients With Knee Osteoarthritis: A Retrospective Claims Analysis
Authors: Mark Josh , Shema-Shiratzky Shirley , Sommer Joel , Nolan Tim , Segal Ganit
Published: May 2024

Background: One in 7 US adults has knee osteoarthritis (OA) and almost two-thirds of them suffer from low back pain. OA is the third most rapidly rising condition associated with disability and leads to a significant burden on the healthcare system and society. Objective: This study looked at the healthcare resource utilization (HCRU) in patients with knee OA and low back pain before and after the utilization of a new, home-based, noninvasive, biomechanical intervention. Methods: This was a retrospective claims analysis of 585 patients treated with a personalized, noninvasive, home-based, biomechanical treatment that aims to alleviate knee pain and improve function (AposHealth®). The date of the first AposHealth claim was the index date. Data prior to the index date and post-index date were used to monitor changes in HCRU while in treatment. Descriptive statistics, including frequencies, means and standard deviations, were used to present patient characteristics. To standardize the results, an average monthly claims data rate was calculated and an expected annual rate was extrapolated. Annual HCRU rate per 1000 members was calculated. Results: HCRU decreased after utilizing the new intervention including a decrease of 79% in diagnostic claims, a 70% decrease in outpatient services, a 22% decrease in non-operative treatments, a 61% decrease in pain medications including an 85% drop in opioids use, and a 44% decrease in intra-articular injections. The pre-index estimated rate for total knee replacement (TKR), which is based on existing literature, was 15.1%, whereas the post-index rate of TKR was 0.9%. Conclusions: Patients with knee OA treated with a home-based, noninvasive, biomechanical intervention incurred fewer healthcare resources, leading to an overall reduction in the cost of care.
FORMULATION AND EVALUATION OF NASAL INSITU-GEL OF ELETRIPTAN FOR THE TREATMENT OF MIGRAINE
Authors: Bhoomi S. Patel  , Dr. Sachin.B. Narkhede  , Abhay H. Rana  , Mrunali S. Patel  , Jinal G. Barodia  , Sofiya S. Bhojani  , Janhvi D. Nemade
Published: May 2024

Nasal in situ gel based formulations are those which upon administration get converted into gel by various mechanism like pH , Temperature & other factor. Eletriptan is BCS class 1 drug with lesser aqueous solubility which is used for Migrane. Existing market formulation include tablet for the same with less than 50 percentage bioavailability because of cytochrome induction and first pass metabolism. Mainly cause for failure of the formulation to achieve desired bioavailability and therapeutic action is because of first pass metabolism and cytochrome induction which can be avoided by nasal delivery. Polaxomer 407 and Carbopol 934 used to formulate the nasal in situ gel of Eletriptan by cold method of preparation. While polyethylene glycol400 increase the solubility of drug in polaxomer along with increasing the permeation through nasal membrane. Hence by formulating nasal in situ gel of Eletriptan we can avoid FTM and get brain targeted drug delivery for the migrane.
KEYWORDS: Nasal in-situ gel, Eletriptan, Migraine, cytochrome induction, first pass metabolism, brain targeted drug delivery.
SPECTRAL DENSITY ANALYSIS: APPLICATION OF THE METHOD IN DETERMINING THE BOUNDARIES OF LONG-TERM ECONOMIC CYCLES
Authors:   Doctor of Economics, Financial University under the Government of Russia, Shcherbakov Gennady A.
Published: May 2024

Verification of hypotheses in economic science is a necessary condition for the further development of the put forward scientific assumptions. In this part, the expansion of the set of available means of testing the scientific validity of the revealed regularities and hypotheses built on their basis is an important direction in the development of scientific thought. It is known that one of the directions of economic theory tries to explain economic processes on the basis of physical laws. Taking into account the controversial nature of this approach, a natural question arises concerning the possibility of applying in economic research the methods successfully tested in exact sciences. The presented article describes such an experience, where the method of spectral plane analysis was used to verify the assumption of the existence of systemic economic crises and to determine the chronological boundaries of longterm economic cycles.