bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening Stability, Thermochemistry, and Chemical kinetics of 3-Hydroxy butanoic acid as a bi-functional biodiesel additive
Authors: Abdel-Rahman Mohamed A.
Published: December 2023

Thermo-kinetic aspects of 3-Hydroxybutanoic acid (3-HBA) pyrolysis in the gas phase have been studied computationally in the temperature range 600–1700 K and pressure of 1 bar using the ab initio CBS-QB3 method and M06-2X/cc-pvTZ level with the aid of the Gaussian 09 program and the Kinetic and Statistical Thermodynamical Package (KiSThelP). The degradation mechanism was divided into seventeen pathways: seven complex fissions and ten barrierless reactions. Chemical kinetics simulations of barrier reactions are calculated using transition state theory (TST) and unimolecular Rice-Ramsperger-Kassel-Marcus (RRKM) theories, while the kinetics of barrier reactions are estimated using the accurate classical method. Thermodynamics results indicate six stable conformers within 4 kcal mol− 1. To confirm the chemical stability of these conformers, the HOMO-LUMOs energy gaps were checked. The estimated chemical kinetics results indicated that TST and RRKM are comparable which gives confidence to our calculations. Branching ratio analysis shows the full dominance of the dehydration reaction R4 at T ≤ 650 K, with a minor contribution for the simple bond fission R9. At T ≥700 K, R9 became the main decomposition route, with a small contribution from R10 (~ 16% at 1700 K) and R8 (~ 9% at 1700 K) reactions.
Detection of deep and shallow defects in Concrete Filled Steel Tube Using Impact-Echo Method
Authors: Twite Franck Ngole , Fei Yao
Published: December 2023

Concrete Filled Steel Tube (CFST) is widely used in construction due to its good bearing performance, low cost and excellent structural seismic performance. Quality problems such as voids and debonding are often encounters in the process of pouring CFST. They significantly reduce the bearing capacity and ductility of specimens, and adversely affect the restraining effect of concrete. Such internal hidden defects cannot be visually identified. However, Non-destructive Testing Technique (NDT) is required. This paper employed the Impact Echo (IE) method to determine the location of defects in various types of concrete structures. Since the IE method was developed in the 1980s and used to test concrete structures, there have been little researches on defect detection in CFST. Therefore, this paper studies the square CFST specimens with defects located at different depths which are tested using the IE method. The Fast Fourier Transform (FFT) was employed to detect the location of defects by analyzing waveform and frequency spectrum. In addition, the CFST finite element model under more working conditions has been established, including internal defects of different depths and widths. The analysis of frequency distribution provides more details about the depth and location of the defects. A time-frequency analysis using Wavelet Transform was introduced in this study to assess the reliability of the IE method. According to the models carried out in this work it is demonstrated that IE method has been able to detect defects in Concrete Filled Steel Tube.
Complete classification of two classes of two-dimensional PI-algebras over any basic field
Authors: I.Rakhimov  , H.Jamil  , Nasir R.N.Mohd
Published: December 2023

In the paper we give complete classification of two classes of two-dimensional PI-algebras over any basic field. The choice of these two classes is predicted by the polynomial identities of the classes: the identity of one of them is given by using the binary operation of the algebra another one involves the bracket operation in the identity. The list of the representatives of isomorphism classes are provided. We compare our list with that obtained earlier, where such a classification was given under certain constraints on the basic field.
PERSONAL COMPONENT OF GRAPHOMOTOR SKILLS OF CHILDREN AGED 5-8 YEARS
Authors: Demenko Maryna , Harbuzova Viktoriia , Obukhova Olha , Biesiedina Antonina , Levchenko Zoya
Published: December 2023

Aim: to assess the personal component of graphomotor skills in children aged 5-8 years. The period of a child's individual development coincides with the beginning of schooling and is marked by increased sensitivity of the body to factors in the external environment, which can lead to disharmonious development and deterioration of health. This justifies the search for new approaches in the development of criteria for prognostic assessment of the development level of senior preschoolers and junior schoolers.
The object of the research is the personality characteristics of children and the level of neuroticism.
Material and methods. Students of grades 1–2 (6–8 years) and children of preschool age (5 years) from secondary schools and preschools in Sumy (Ukraine) (five secondary schools and four preschools in the city, 487 children were examined) participated in the study. Assessment of the level of neuroticism in children was performed using six scales reflecting the main aspects of the manifestation of neurotic changes in children: level of depression, asthenia, behavioral reactions, autonomic disorders, sleep disorders, and anxiety.
Part of the simplest mathematical processing was performed on a personal computer using the standard statistical packages Statgrhics, STATISTICA (descriptive statistics, Student's test, correlation, variance and factor analyses; risk calculation). The Excel package was used for the initial preparation of tables and intermediate calculations.
Results. For children aged 5–8 years with low levels of graphomotor skills, the scores of the scales "level of depression", "asthenia", "behavioral reactions", and "anxiety" were higher compared to the scores of the children with average levels of graphomotor skills. This conclusion was confirmed by the established direct correlation between the graphomotor skills indicator and emotional stability (r = 0.32, p < 0.01), which indicated an increase of children's emotional stability with an increase in the level of graphomotor skills formation.
Conclusions. It has been established that the indicators of borderline neurotic disorders of children aged 5–8 years are at low levels of formation, that is, there are no signs of their manifestations, which indicates the absence of a decrease in vitality, low self-esteem, slow thinking, motor limitations, feelings of depression.
The inverse correlation between the indicator of graphomotor skills and the average values of the "behavior disorder" scale indicates an increase in manifestations of hyperactivity of children when graphomotor skills are not formed (r = -0.22, p < 0.05).
ChatGPT-4 for Hospitality: Implications
Authors: ÜLKÜ Abdullah
Published: December 2023

The aim of this study is to examine the several applications of ChatGPT-4 for the hospitality industry and to provide an agenda of research for investigating the potential implications of this model in the domain of hospitality. Questions, based on studies in the literature, were asked to ChatGPT-4 to see the opportunities it can offer to the hotel industry. This study, which discusses chatbots and artificial intelligence, suggests several potential applications of ChatGPT for the hospitality sector. The study’s suggestions are derived from previous research conducted on ChatGPT and a review of existing literature related to the topic. It is quite likely that ChatGPT-4 will have a significant influence on the hospitality industry. This chatbot will probably contribute to concierge services, booking hotels for tourists, giving feedback, room services, translation, training employees, operational efficiency, marketing hotels, and travel guidance.
Image-Based Social Media Usage, Holiday Preference, Conspicuous and Status Consumption: Intergenerational Differences
Authors: YILDIZ S. Banu , KAZOĞLU İbrahim Halil
Published: December 2023

Social media refers to the platforms that were introduced during the advent of Web 2.0. These platforms permit users to create and manage their own content. Additionally, social media has been instrumental in transforming our understanding of identity. It has become mandatory for social media users to demonstrate and authenticate their identity to others. This responsibility has spurred some users to cultivate a new persona or augment their current one by sharing unrealistic content with the intention of receiving recognition, adoration and esteem. Moreover, social media has a significant impact on consumption patterns. Historically, consumption was solely about fulfilling basic needs, whereas today it has taken on more of a symbolic meaning. Two examples of this phenomenon include conspicuous consumption and status consumption. The research aims to identify distinctions in social media usage, conspicuous and status consumption trends, and holiday preferences between generations as potential tourists, with the purpose of creating a desirable image. The study analyzed data derived from 697 potential tourists and concluded that there are variations in the use of image-centric social media, conspicuous consumption, and holiday preferences across X, Y and Z generations. No differences in terms of status consumption were found. However, these variances do play an important role in the consumption habits of various generations and the technological opportunities available during their formative years. Marketers can positively affect the effectiveness of their marketing activities through careful analysis of generational consumption patterns and the development of targeted marketing approaches for specific generations.
A New Framework for Cyber Risk Assessment for IIoT and Recommendations for Vietnam
Authors: Tuan Bui Minh , Khoa Tran Viet , Son Do Hai , Linh Trung Nguyen , Quynh Tran Thi Thuy , Ha Nguyen Viet , Hoa Nguyen Ngoc , Tho Nguyen Dai , Minh Le Quang
Published: December 2023

Industry 4.0 has brought huge benefits to a wide range of industries. Its development, however, has raised more cyber security risks in both Information Technology (IT) and Operational Technology (OT) systems. In this paper, potential cyber vulnerabilities and threats in manufacturing in Industry 4.0 are briefly reviewed based on the architecture and operating principle of the manufacturing system in Industry 4.0. Criteria for cyber risk assessment for both IT and OT are reviewed via different standards. We then provide recommendations for cyber risk assessment and discuss a new framework for IT/OT risk assessment in Vietnam.
Presencia curricular de la asignatura de psicología del deporte en planes de estudio de psicología y educación física, en Colombia
Authors: Urrea Cuéllar Ángela , Gutiérrez Carmona Camila , Barbosa Granados Sergio
Published: December 2023

El presente estudio tuvo como objetivo conocer la presencia curricular de la asignatura Psicología de la Actividad Física y del Deporte en los planes de estudio de los programas de Psicología y Educación Física en Colombia. Correspondió a un estudio descriptivo y transversal que tuvo en cuenta 133 programas de Psicología y 45 de Educación Física, registrados en el Sistema Nacional de Información de Educación Superior. Dentro de los resultados se evidenció mayor presencia de la asignatura en los programas de Educación Física, con un 48,88 %, que, en los programas de Psicología, con un 39,06 %. Se concluye que la asignatura de Psicología del Deporte tiene mayor presencia en programas de Educación Física que en Psicología, lo que vislumbra el proceso interdisciplinar y transdisciplinar del objeto de estudio. Este es también un llamado a los programas de Psicología a incluir en sus planes de estudio este campo, lo que permitiría un diálogo más profundo y colaborativo con las ciencias del deporte, en consonancia con el enfoque transdisciplinario que aborda las complejidades de esta área.
Experiencias docentes sobre la enseñanza transversal de la semiología en un programa de medicina de una universidad colombiana
Authors: Vallejo Hernández Jimmy Alexander
Published: December 2023

El objetivo de esta investigación fue caracterizar las experiencias docentes sobre la enseñanza transversal de la semiología en un programa de medicina de una universidad colombiana. Para esto, se planteó un estudio sociocrítico con un enfoque cualitativo. Como método, se utilizó la sistematización de experiencias. Para la recolección de datos se construyó y empleó una entrevista semiestructurada, la cual fue validada por medio de pares expertos. Se realizaron ocho entrevistas a médicos-profesores, vinculados a la enseñanza de la semiología dentro del programa de formación médica. Las entrevistas fueron codificadas y analizadas bajo los criterios del análisis temático, lo que implicó una codificación cerrada, una abierta y un análisis cruzado en el que se dotaron de sentido, a partir de antecedentes bibliográficos, los resultados de la investigación. Las  conclusiones indican que para la enseñanza de la semiología es necesario fortalecer: la formación continua docente, el uso de la telemedicina y de las TIC, un acercamiento temprano del estudiante al escenario clínico y un reposicionamiento de esta asignatura dentro de la estructura curricular del programa.
Sobre Hermenêutica Pluritópica, Pensamento Trans-moderno e Filosofia Decolonial
Authors: Vladimirovna Tlostanova Madina , D. Mignolo Walter , Gomes Lopes Vitor
Published: December 2023

Tradução de Vitor Gomes Lopes do artigo "On Pluritopic Hermeneutics, Trans-modern Thinking, and Decolonial Philosophy" de Madina Vladimirovna Tlostanova e Walter Mignolo.
MORTALIDADE POR COVID-19 NA REGIÃO NORDESTE DO BRASIL ENTRE 2020 E 2021: UM ESTUDO ECOLÓGICO
Authors: Souza Larissa Beatriz Francisca de , Cruz Maria de Lourdes Alves da , Costa Ketyllem Tayanne da Silva , Morais Thiffany Nayara Bento de , Andrade Fábia Barbosa de
Published: December 2023

Introdução: A pandemia do COVID-19 foi responsável por um número significativo de mortes em todo o mundo. No Brasil, o país atingiu o terceiro lugar no ranking mundial em número de casos, em um curto período de tempo. A região nordeste por sua vez apresenta altas taxas de incidência e mortalidade. Objetivo: Analisar a mortalidade por COVID-19 na região Nordeste do Brasil entre os anos de 2020 e 2021. Metodologia: Trata-se de um estudo ecológico, retrospectivo com abordagem quantitativa, utilizando dados secundários, disponíveis no Portal de Transparência do Registro Civil, considerando os registros das Semanas Epidemiológicas (SE). Foram incluídas as variáveis: quantidade de óbitos, sexo, faixa etária, estados e semana epidemiológica. Resultados: Observou-se a ocorrência de dois picos acentuados de óbito durante as SE 18ª e 30ª e 7ª e 25, nos anos de 2020 e 2021, respectivamente. O estado do Ceará manteve os maiores índices nas duas curvas, seguido da Paraíba e Sergipe. Quanto a faixa etária, a população idosa foi mais acometida e prevaleceu os óbitos entre sexo masculino. Conclusões: Os dados mostraram a magnitude da pandemia na região nordeste, fornecendo informações para subsidiar possíveis medidas sanitárias pelas autoridades competentes.

Palavras-Chave: Covid-19; Região Nordeste; Mortalidade.
MODELO LÓGICO-TEÓRICO COMO FERRAMENTA DE PLANEJAMENTO PARA MELHORIA DA COBERTURA VACINAL INFANTIL NO RIO GRANDE DO NORTE, BRASIL
Authors: Silva Ísis de Siqueira , Lira Monique Léia Aragão de , Souza Ana Elisa Barboza de , Cavalcante Elisângela Franco de Oliveira , Andrade Fábia Barbosa de
Published: December 2023

Introdução: A vacinação tem se apresentado como uma importante estratégia de proteção à saúde da população. A redução da cobertura vacinal é um alerta para o retorno de doenças  imunopreveníveis que já haviam sido erradicadas. Objetivo: Analisar a cobertura da imunização de crianças menores de 2 anos no Rio Grande do Norte entre os anos de 2018 e 2021 para fins de construção de  planejamento pautado no  modelo teórico-lógico. Metodologia: Trata-se de um estudo do tipo ecológico, retrospectivo, acerca da cobertura vacinal no Rio Grande do Norte. Os dados foram coletados a partir do Departamento de Informática do Sistema Único  de  Saúde  (DATASUS),  por  meio  das  Informações  em  Saúde  (TABNET). Para coleta dos dados, elegeu-se como variáveis o ano para compor a linha da tabela a ser gerada pelo sistema, o  imunobiológico  para  compor  a  coluna  e,  como  medida,  foi selecionada a cobertura vacinal. O período analisado foi de 2018 a 2021. Resultados:  A realidade vacinal dos últimos dois anos no Brasil e no RN acompanha o cenário internacional, durante a pandemia 2020/2021 os dados de cobertura vacinal no RN  se apresentaram piores, quando comparados aos anos de 2018/2019. O modelo lógico teórico apresentado neste estudo busca contribuir para a melhoria do planejamento e das ações do programa estadual de imunização.Conclusão: Este estudo se mostrou relevante para direcionar as estratégias da Secretaria de Saúde Pública do RN, pois corrobora com a literatura, apresenta o problema na cobertura vacinal do RN nos últimos anos, e propõe como ferramenta para melhorar essa taxa, o modelo teórico-lógico.
PRÉ-NATAL ODONTOLÓGICO: PERCEPÇÃO DAS GESTANTES ATENDIDAS NO MUNICÍPIO DE VILHENA- RO
Authors: Nascimento Roberto Pereira do , Rockenbach Valeria Barão Machado
Published: December 2023

RESUMO

Introdução: O Pré Natal Odontológico é um programa de acompanhamento à gestante com um enfoque na saúde bucal que oferece tratamento personalizado trazendo mais confiança e segurança para as gestantes. Porém, ainda há muitas barreiras para o acesso a esses serviços na atenção básica. Objetivo: Avaliar a percepção das gestantes que se encontram em acompanhamento do Pré-natal nas Unidades Básicas de Saúde no município de Vilhena (RO) sobre a importância do pré-natal odontológico bem como sobre sua saúde bucal. Metodologia: Um questionário com perguntas diretas foi aplicado, nas dependências das Unidades Básicas de Saúde. Resultados: Quando questionadas sobre sua percepção em relação à saúde bucal, a maioria das gestantes diziam que a saúde bucal estava em boas condições (71,2%) e 28,8% não estavam satisfeitas com a saúde bucal. Conclusões: Portanto, as gestantes presentes neste estudo apresentam uma autopercepção positiva em relação a saúde bucal, evidenciando uma melhor interesse na escuta do profissional dentista e consequentemente uma melhora no cuidado da saúde bucal.

Palavras-Chave: Cuidado Pré-Natal; Saúde bucal; Unidade de saúde.
MORTALIDADE MATERNO-INFANTIL EM UM ESTADO NORTISTA BRASILEIRO: COERÊNCIA E DISCREPÂNCIA ENTRE INSTRUMENTOS DE GESTÃO E AGENDA 2030
Authors: De Melo Nayra Carla , Pereira Lima Cunha Mônica
Published: December 2023

Introdução: As mortes maternas e infantis refletem as condições de vida de uma determinada população e são marcadores importantes de desenvolvimento de uma nação, reduzi-las tornou-se prioridade na Agenda 2030 de desenvolvimento sustentável. Políticas públicas devem ser formuladas, executadas e monitoradas em escalas nacionais, estaduais e locais para melhorar a qualidade de vida e cumprir os compromissos pactuados nacional e internacionalmente. Objetivo: identificar o alinhamento dos indicadores e os resultados alcançados nas metas para redução de mortalidades materna e infantil do Plano de Desenvolvimento Sustentável e Plano Estadual de Saúde do Estado de Rondônia com Agenda 2030. Metodologia: Trata-se de uma pesquisa documental e bibliográfica com análise crítica de indicadores referentes à redução da mortalidade materno-infantil na Agenda 2030 e respectivos ações e metas alcançadas ou não contempladas no Plano de Desenvolvimento Sustentável de Rondônia (2015-2030) e Planos Estaduais de Saúde (2016-2019 e 2020-2021). Verificou-se os resultados alcançados em relatórios da sociedade civil e anual de gestão. Resultados: Constatou-se que a redução das mortes materna e infantil são destacadas nos planejamentos analisados, contudo a mortalidade infantil contida nos planos considera somente as mortes em menores de um ano de vida e há incompletudes nos escopos selecionados para o monitoramento, assim como diferentes indicadores de verificação, dificultando análise das metas pactuadas na Agenda 2030. Conclusões: Os relatórios dos resultados alcançados apontaram retrocessos para o alcance das metas. Instrumentos de gestão e planejamento são imprescindíveis para nortear ações e estabelecer prioridades, porém para que haja avanços é necessário coerência não somente em metas pactuadas, mas nos indicadores e meios de verificação a fim de corroborar para análise e retroalimentação do planejamento.

Palavras-Chave: mortalidade materna; mortalidade infantil; objetivo desenvolvimento sustentável; políticas públicas; planejamento em saúde.
ENDOMETRIOSE E SAÚDE SEXUAL FEMININA – DESAFIOS, TRATAMENTO, PERFIL EPIDEMIOLÓGICO E IMPACTOS BIOPSICOSSOCIAIS: UMA REVISÃO INTEGRATIVA
Authors: Cirino Geovana Aparecida dos Reis , Loiola Samuel Lako , Carvalho Thaís Aparecida de , Coelho Stéfane Martins , Azevedo André Herácleo de
Published: December 2023

Introdução: A endometriose consiste em uma patologia ginecológica bastante prevalente em mulheres de múltiplas faixas etárias, consistindo em um desafio constante para a fertilidade, sexualidade e demais aspectos da qualidade de vida. Objetivo: Avaliar o perfil epidemiológico, formas de tratamento e os aspectos biopsicossociais associados à saúde sexual das mulheres com endometriose. Metodologia: Esta é uma revisão integrativa da literatura cuja pergunta norteadora foi “Como a endometriose influencia nos aspectos biopsicossociais inerentes ao comportamento sexual feminino?". Foi aplicada a estratégia de busca “Endometriose AND Dispareunia AND Qualidade de Vida” na Biblioteca Virtual em Saúde (BVS) e sua versão em inglês “Endometriosis AND Dyspareunia AND Quality of Life” na base de dados PubMed, com o filtro “últimos 10 anos” aplicado em ambas as plataformas. Critérios de inclusão: estudos que abordassem mulheres cisgênero, em idade fértil, com vida sexual ativa, diagnóstico prévio de endometriose pélvica ou profunda e distúrbios ou queixas sexuais. Critério de exclusão: artigos que contemplassem mulheres em uso de psicofármacos. Resultados: Inicialmente, foram obtidos 227 artigos. Após análise primária, 189 estudos foram excluídos, seguindo para a etapa seguinte apenas 38. Destes, somente 15 atenderam aos critérios e foram considerados válidos para compor o presente estudo. No âmbito sexual, a endometriose pode acarretar a redução da frequência das relações, sangramentos durante ou após o coito, desinteresse em preliminares, desconforto em certas posições, términos de relacionamentos, conflitos conjugais, e, sobretudo, dispareunia. Conclusões: Diante dos prejuízos em diversos âmbitos da vida e bem-estar feminino causados pela endometriose, faz-se indispensável maior qualificação dos serviços de saúde para o diagnóstico precoce e intervenções efetivas, bem como apoio, acolhimento e acompanhamento multiprofissional contínuo. Além disso, a adaptação, compreensão e solicitude dos parceiros são fundamentais para que as mulheres sejam capazes de melhor gerenciar tais desafios.
Palavras-Chave: Endometriose; Dispareunia; Qualidade de vida; Saúde da mulher; Comportamento Sexual.
SELF-MEDICATION ASSOCIATED WITH TOOTHACHE: A SYSTEMATIC LITERATURE REVIEW
Authors: Figueiredo Mariana Souto , Nepomuceno Ana Flávia Souto Figueiredo , Castro Caroline Tianeze de , Gama Romana Santos , Oliveira Marcio Galvão
Published: December 2023

Introduction: Self-medication consists of selecting and using medication without a prescription or guidance from a healthcare professional. This practice has been widely reported worldwide, which has contributed to a series of adverse health outcomes, such as delayed diagnosis, worsening of clinical conditions, drug interactions, intoxication, and adverse reactions, which tend to compromise patient safety. Objective: To analyze the prevalence of self-medication associated with toothache, the main factors associated with self-medication in dental patients, as well as outline the profile of medications used by these individuals, the preferred route of administration, and the main sources of medication. Methodology: A systematic review was developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Relevant articles published in the last ten years, without limitations of language were searched using the following descriptors/MeSHterms and keywords: "self-medication" and (toothache or "dental pain") not Child.  Results: The initial search returned 57 manuscripts. Fourteen papers, all cross-sectional studies, were eligible for inclusion in the systematic review. Conclusions: The prevalence of self-medication for toothache ranged from 6.5% to 100.0%. Cultural and economic factors, barriers to access, the high cost of dental treatments, lack of time and money, and the perception that dental problems are not a serious problem are among the main factors associated with the practice. Regarding the drugs used, the most used classes were paracetamol, especially anti-inflammatory drugs, particularly ibuprofen, and analgesics administered orally.
Editorial
Authors: Moraes de Oliveira Adriano
Published: December 2023

Texto de apresentação do volume 6, número 2 (2023) da Manzuá - Revista de Pesquisa em Artes Cênicas.
Regions of the Volga Federal District: Assessing the Effectiveness of SocioEconomic Policy Based on the Life Quality of the Population
Authors: Bikeeva M. V. , Koroleva Ju. G.
Published: December 2023

Purpose of the study. The socio-economic policy of the state is a purposeful activity for the redistribution of resources in order to achieve the well-being of the population. Its purpose is to solve the socio-economic problems of the population in the field of maintaining a decent standard of living, ensuring employment of the population, regulating labor relations, social protection and development of sectors of the social sphere. The purpose of the study is a statistical analysis of the life quality of the population of the Volga Federal District to assess the effectiveness of the ongoing socio-economic policy.

Materials and methods. The methodological basis of the study was the aggregation method, which makes it possible to calculate indicators of advantages: advance, parity and lag behind the Russian average level. The calculation of the integral assessment was carried out without taking into account the weighting coefficients of the life quality components. To assess the life quality of the population, 10 parameters have been identified that affect key areas of social policy: financial situation, labor activity, housing conditions, life safety, public health, education, culture, transport infrastructure, information and communication resources, and the life potential of the population. Each quality of life parameter is characterized by a range of private indexes. The information base of the study is data from the Federal State Statistics Service.

Results. The calculation results confirm the high differentiation of the regions of the Volga Federal District in terms of life quality parameters of the population. Not a single region of the Volga Federal District has been identified with stable behavior of the indicator of advantages. Only two regions of the Volga Federal District have an integral index value greater than one: Nizhny Novgorod region and the Republic of Mari El. For most life quality parameters, these regions are ahead of the Russian average. In other regions of the Volga Federal District, the values of integral indexes are less than one, which indicates a lag behind the Russian average level of various life quality parameters. The region with the lowest integral assessment value is the Republic of Mordovia.
Modelos pedagógicos em EAD para formação continuada
Authors: Assis Mário dos Santos de , Abranches Sérgio Paulino
Published: December 2023

Este artigo visa analisar os modelos pedagógicos para EaD utilizados pelas Escolas de Governo da Justiça do Trabalho no Brasil. De natureza qualitativa e com abordagem por estudo de casos múltiplos, a coleta de dados utilizou pesquisa documental e questionário on-line semiestruturado. Os dados foram tratados por análise documental temática e análise de conteúdo categorial. O quadro teórico repousou em modelos pedagógicos para EaD, interação em ambientes virtuais, tecnologias e mídias educacionais e treinamento e desenvolvimento (T&D). O estudo concluiu que predomina modelo pedagógico com concepção de aprendizagem na perspectiva cognitiva, com prevalência de cursos no formato autoinstrucional e utilização de tecnologias educacionais com característica de comunicação assíncrona, rica em símbolos comunicacionais e interações mútua e reativa. Os resultados apontam que o modelo utilizado estimula o autodesenvolvimento do corpo funcional, aproveitando as potencialidades das TDIC na indução de aprendizagem. Sugere-se investigar o impacto do modelo adotado na cultura organizacional.
Marein Ameliorates Myocardial Fibrosis by Inhibiting HIF-1α and
TGF-β1/Smad2/3 Signaling Pathway in Isoproterenol-stimulated Mice and
TGF-β1-stimulated Cardiac Fibroblasts
Authors: Niu Guanghao , Zhao Ying , Song Huafeng , Song Quan , Yin Xiaoyun , Zhu Zengyan , Xu Junchi
Published: December 2023

Background:

Myocardial fibrosis significantly contributes to the pathogenesis and progression of
heart failure.

Objective:

We probe into the impact of marein, a key bioactive compound in functional food Coreopsis tinctoria,
on isoproterenol-stimulated myocardial fibrotic mice and transforming growth factor β1 (TGF-β1)-stimulated
cardiac fibroblasts (CFs).

Methods:

Isoproterenol was administered to the experimental mice via subcutaneous injection, and simultaneous
administration of marein (25-100 mg/kg) was performed via oral gavage. CFs were stimulated with TGF-
β1 to trigger differentiation and collagen synthesis, followed by treatment with marein at concentrations of
5-20 μM.

Results:

Treatment with marein in mice and CFs resulted in a significant reduction in the protein expression
levels of α-smooth muscle actin, collagen type I, and collagen type III. Additionally, marein treatment decreased
the protein expression levels of TGF-β1, hypoxia-inducible factor-1α (HIF-1α), p-Smad2/3, and
Smad2/3. Notably, molecular docking analysis revealed that marein directly targets HIF-1α.

Conclusion:

Marein might exert a protective function in isoproterenol-stimulated myocardial fibrotic mice
and TGF-β1-stimulated CFs, which might result from the reduction of TGF-β1 induced HIF-1α expression,
then inhibiting p-Smad2/3 and Smad2/3 expressions.
Breaking Barriers: Current Advances and Future Directions in Mpox
Therapy
Authors: Shah Bhumi M. , Modi Palmi
Published: December 2023

Background:

Mpox, a newly discovered zoonotic infection, can be transmitted from animal
to human and between humans. Serological and genomic studies are used to identify the
virus

Objective:

Currently, there are no proven effective treatments for Mpox. Also, the safety and efficacy
of intravenous vaccinia immune globulin, oral Tecovirimat (an inhibitor of intracellular viral
release), and oral Brincidofovir (a DNA polymerase inhibitor) against the Mpox virus are uncertain,
highlighting the need for more effective and safe treatments. As a result, drug repurposing
has emerged as a promising strategy to identify previously licensed drugs that can be repurposed
to treat Mpox.

Results:

Various approaches have been employed to identify previously approved drugs that can
target specific Mpox virus proteins, including thymidylate kinase, D9 decapping enzyme, E8 protein,
Topoisomerase1, p37, envelope proteins (D13, A26, and H3), F13 protein, virus's main cysteine
proteases, and DNA polymerase.

Conclusion:

In this summary, we provide an overview of potential drugs that could be used to
treat Mpox and discuss the underlying biological processes of their actions.
An Eco-friendly Strategy for the Synthesis of Spiro-benzimidazoquinazolinone
and Spiro-benzothiazoloquinazolinone Derivatives using β-cyclodextrin as a
Supramolecular Catalyst
Authors: Baranwal Jyoti , Singh Swastika , Kushwaha Smriti , Jyoti Archana
Published: December 2023

Background:

Cyclodextrins selectively bind with reactants and facilitate chemical reactions through supramolecular catalysis, similar to the mechanisms employed by enzymes. In this
paper, β-cyclodextrin was used as a supramolecular catalyst in water as a green, reusable, and ecofriendly solvent system to synthesize spiro-benzimidazoquinazolinones and spiro-benzothiazoloquinazolinones.

Objective:

A supramolecular catalyst β-cyclodextrin (β-CD) is used to synthesize spiro- benzimidazoquinazolinones and spiro-benzothiazoloquinazolinones via multicomponent reaction involving
the condensation of dimedone, isatin, and 2-aminobenzimidazole/2-aminobenzothiazole.

Methods:

In a 50 mL round bottom flask were added the respective mixture of substituted isatin (1
mmol), dimedone (1mmol), and 2-aminobenzimidazole/2-aminobenzothiazole (1 mmol) in water
(5ml) containing β-CD (113 mg, 10 mol. %) was stirred at 60oC for 30 min. The desired product
was obtained with excellent yield. After completion of the reaction (monitored by TLC), the reaction
mixture was quenched with water and extracted with ethyl acetate (4X5ml). The combined organic
layers were washed with brine solution, dried over anhydrous Na2SO4 and evaporated under reduced pressure. The crude product was purified by silica gel chromatography

Results:

β-cyclodextrin catalyst showed very good efficiency in the synthesis of the desired compounds and can be easily recovered and reused at least five times with minimal deactivation in
catalytic activity.

Conclusion:

The catalyst demonstrated remarkable effectiveness in producing the target compounds
and conducting the reaction with different initial substances, resulting in excellent yields of the
products, thereby confirming the broad applicability and versatility of this method.
First Onset in Adulthood of Mental Disorders: Exposure to War vs. Non-war Childhood Adversities: A National Study
Authors: Karam Elie , Al Barathie Josleen , Saab Dahlia , Karam Aimee Nasser , Fayyad John
Published: December 2023

Background:

There is evidence that some childhood trauma increases the risk of the first onset of mental disorders and for the first time into adulthood. There are no studies that assessed whether exposure to war has this delayed long-term effect.

Objectives:

To fill this gap by investigating the comparative roles of war and non-war trauma on the first onset of adulthood mood and anxiety disorders.

Methods:

A nationally representative sample of 2,857 Lebanese was assessed using the World Health Organization Composite International Diagnostic Interview 3.0. with the onset of exposure to trauma and of first onset of mood and anxiety disorders.

Results:

Non-war childhood traumata especially those belonging to family malfunctioning continue to exert their effect for the first time well beyond their occurrence as they were the most universal predictors for adult onset of both mood and anxiety disorders. War trauma during childhood predicted mood anxiety and mood (anxiety only in males) only below age 18 y. war childhood trauma predicts the first onset of mood and anxiety disorders before age 18 y in females, but only anxiety in males.

Conclusion:

Childhood traumata are not equal in predicting the first onset of mood and anxiety disorders into adulthood. Family malfunctioning looks to carry the longest such risk and war more of shorter immediate effects. This might change though with re-exposure to war in adulthood which might unravel dormant vulnerability.
Signal Peptide Selection for the Efficient Periplasmic and Secretive Expression of Recombinant Brazzein in Escherichia Coli
Authors: Muminov Muzaffar , Ermatova Khusnora , Sohibnazarova Khonsuluv , Dalimova Dilbar , Turdikulova Shahlo
Published: December 2023

Background:

The high production cost and difficulty of functional expression of brazzein are the limiting factors, making the development of inexpensive, scalable technologies critical for their successful implementation in the market. Secretory expression allows functional expression of the S-S bond-rich proteins and facilitates the purification procedure, resulting in lower processing costs. However, extensive screening and optimization of multiple signal peptides are required to ensure the successful secretion of recombinant proteins.

Objective:

We studied the expression of the minor type of brazzein using 21 different signal peptides in Escherichia coli and investigated their ability to direct the target protein into periplasmic space and culture medium.

Methods:

The synthetic genes were cloned into the pSEVA234 vector under the inducible Trc promoter and initial micro-scale expression analysis was conducted at two distinct conditions followed by scale-up and purification of the selected signal peptides with secretive abilities.

Results:

Two signal peptides led to the secretion of the target protein. The yields of the target protein for MalE_Brazzein and HstI_Brazzein in the periplasm were 11.33 mg/L and 52.33 mg/L, and those in the culture media were 3.975 mg/L and 7.73 mg/L, respectively.

Conclusion:

This study will provide insights into the identification of optimal signal peptides for secretive brazzein expression in E.coli and demonstrate that the abovementioned two signal peptides can be used for successful extracellular production of the target protein in this host.
Productivity of Cherry Tomato Cultivars as Influenced by Watering Capacities and Microclimate Control Designs
Authors: Kusumiyati Kusumiyati , Ahmad Farhan , Khan Muhammad Rabnawaz , Soleh Mochamad Arief , Sundari Ristina Siti
Published: December 2023

Background:

Cherry tomatoes remain relatively expensive due to limited public knowledge, few producers, and lower productivity rates in Indonesia. Although cherry tomatoes are increasingly popular in modern marketplaces, they are still uncommon in traditional markets.

Cherry tomatoes have an enormous economic impact on many regions, particularly Indonesia, in the broader agricultural environment. Their cultivation, however, may be impacted by problems with water supply and climatic regulation. By evaluating how various watering capacity and microclimate control strategies affect cherry tomato productivity, this study seeks to address these challenges. The research is anticipated to offer farmers and agricultural practitioners useful information to improve cherry tomato output in response to market demands and sustainability concerns.

Objectives:

The objective of this study is to determine the effect of cultivars on the growth, yield, and quality of cherry tomatoes.

Methods:

The research is designed to determine the effect of each cultivar (Ruby, Fortesa), watering capacities (100% ETc, 75% ETc, 50% ETc), and microclimate control designs (Greenhouse, Rain shelter, Screen house) on the growth, yield, and quality of cherry tomatoes.

Results:

The cultivar Fortesa produced the highest possible fruit, biological yield per plant, maximum marketable fruit output, greater growth index, maximum fruit firmness, and water use efficiency. The cultivar Ruby performed better in terms of root-shoot ratio and fruit elasticity. The greenhouse produced the highest possible fruit and biological yield per plant, marketable fruit yield, growth index, leaf chlorophyll content, fruit firmness, elasticity and water use efficiency. In the watering capacities treatment condition, 100% ETC was more significant for parameters, such as marketable fruit yield, root-shoot ratio, growth index, leaf chlorophyll content, fruit firmness, and elasticity.

Conclusion:

Growing cherry tomato cultivar Fortesa in a greenhouse using a watering capacity of 100% ETc under the results is recommended. These conditions have improved fruit quality, making them favorable options for successful cherry tomato cultivar production.
Improvements in Adolescents’ Disordered Eating Behaviors in a Collaborative Care Digital Mental Health Intervention: Retrospective Observational Study
Authors: Huffman Landry Goodgame , Lawrence-Sidebottom Darian , Beam Aislinn Brenna , Parikh Amit , Guerra Rachael , Roots Monika , Huberty Jennifer
Published: December 2023

Background

Young people today are exhibiting increasing rates of disordered eating behaviors, as well as eating disorders (EDs), alongside other mental and behavioral problems such as anxiety and depression. However, limited access to mental health care means that EDs, disordered eating behaviors, and comorbid mental health problems are often underdiagnosed and undertreated. Digital mental health interventions (DMHIs) offer accessible and scalable alternatives to traditional treatment modalities, but their effectiveness has not been well established among adolescents with EDs and disordered eating behaviors.

Objective

This study uses data from a collaborative care pediatric DMHI to determine whether participation in a DMHI is associated with a reduction in adolescents’ disordered eating behaviors.

Methods

Adolescent members in care with Bend Health Inc completed the SCOFF questionnaire at baseline (before the start of care) and approximately every month during care to assess disordered eating behaviors. They also completed assessments of mental health symptoms at baseline. Member characteristics, mental health symptoms, and disordered eating behaviors of adolescents with elevated SCOFF scores at baseline (before the start of care) were compared to those of adolescents with nonelevated SCOFF scores at baseline. Members participated in web-based coaching or therapy sessions throughout the duration of mental health care.

Results

Compared to adolescents with nonelevated SCOFF scores (n=520), adolescents with elevated SCOFF scores (n=169) were predominantly female and exhibited higher rates of elevated anxiety and depressive symptoms. SCOFF scores decreased over time in care with the DMHI for 61.4% (n=70) of adolescents with elevated SCOFF scores, and each additional month of participation was associated with greater improvements in disordered eating behaviors (F1,233=72.82; P<.001).

Conclusions

Our findings offer promising preliminary evidence that participation in mental health care with a collaborative care DMHI may be beneficial in the reduction of disordered eating symptoms in adolescents, including those who are experiencing comorbid anxiety and depressive symptoms.
Warisan Budaya dalam Konteks Standar Internasional: Penjagaan Warisan Budaya Untuk Pembangunan Berkelanjutan
Authors: Ramadhan Muhammad Fadil , Adi Prasetijo
Published: December 2023

In the era of globalization, infrastructure and economic development have become the primary focus of countries worldwide. While these projects have the potential to improve quality of life and economic growth, they can also have negative impacts on the environment and cultural heritage. This article discusses the role of international lending institutions, such as Multilateral Development Banks (MDBs), in supporting the preservation of cultural heritage in the context of sustainable development. Literature review is used as the research method to inspect the approaches and efforts made by these institutions in identifying, protecting, and conserving cultural heritage in development projects. Through improved understanding and collaboration among these institutions, businesses, and local communities, the preservation of cultural heritage can become an integral part of efforts towards inclusive and sustainable development. Awareness of the importance of unexpected discovery handling procedures is also crucial to address challenges that may arise during project implementation. With the right measures in place, cultural heritage can be preserved for future generations in sustainable development.

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Dalam era globalisasi, pembangunan infrastruktur dan ekonomi menjadi fokus utama negara-negara di seluruh dunia. Meskipun proyek-proyek ini memiliki potensi untuk meningkatkan kualitas hidup dan pertumbuhan ekonomi, mereka juga dapat berdampak negatif pada lingkungan dan warisan budaya. Artikel ini membahas peran lembaga internasional peminjam dana, seperti Multilateral Development Bank (MDB), dalam mendukung pelestarian warisan budaya dalam konteks pembangunan berkelanjutan. Studi literatur digunakan sebagai metode penelitian untuk menelusuri upaya yang dilakukan oleh lembaga-lembaga ini dalam mengidentifikasi, melindungi, dan melestarikan warisan budaya dalam proyek-proyek pembangunan. Melalui pemahaman dan kolaborasi yang lebih baik antara lembaga-lembaga ini, pelaku usaha, dan komunitas lokal, pelestarian warisan budaya dapat menjadi bagian integral dari upaya menuju pembangunan berkelanjutan yang inklusif dan berkelanjutan. Kesadaran akan pentingnya prosedur penanganan temuan tak terduga juga penting untuk mengatasi tantangan yang mungkin muncul selama pelaksanaan proyek. Dengan langkah-langkah yang tepat, warisan budaya dapat dilestarikan untuk generasi mendatang dalam pembangunan yang berkelanjutan.
Collaborative Governance Process in MSMEs Empowerment through Desa-Preneur Program in Sidoarum Village, Yogyakarta
Authors: Trisnantari Sita Agung , Susilastuti Dewi Haryani , Putri Tri Winarni Soenarto
Published: December 2023

Rural MSMEs have a small business scale in terms of capital, labor, market orientation, and limited technology adoption so Dinas Koperasi and UKM DIY (Department of Cooperatives and SMEs of the Special Region of Yogyakarta) implement MSMEs empowerment policy through the Desa-Preneur Program. The involvement of various stakeholders has been attempted, but this program has not fully targeted all Sidoarum MSME actors. This study discusses the process of collaborative governance in the implementation of the Desa-Preneur Program in Sidoarum Village, Yogyakarta. The research uses a qualitative descriptive method with primary data obtained from interviews, and secondary data collected through documentation and literature. The result showed that collaborative governance indicators have not been fully implemented. The role of lurah as program leader has not been maximized in carrying out the role as a program leader. Not all MSMEs actors participate in mentoring routinely and village economic institutions have not been formed. Several program achievements have been fulfilled, but still require consistent implementation of learning outcomes. The researchers suggest that village government to have more concern bridging out the provincial government and community in term of Desa-Preneur Program implementation. Institutional strengthening of BUMDes and cooperatives is important as a place of collaboration between stakeholders. Desa-Preneur Program in Sidoarum Village must be synergized with other programs and needs to involve other government institutions that support local MSMEs empowerment.
Constraints and Countermeasures of Digital Economy Empowering High-quality Development in Chinese Agriculture
Authors: Huang Ling
Published: December 2023

With the wide application of networking, informatization, and digitization technologies in agriculture, as well as the improvement of farmers’ modern information skills, the digital economy has become an important engine driving high-quality development and digital transformation in agriculture. Digital agriculture is an essential component of the national strategy for “Digital China” and an effective measure to achieve the deep integration of informatization and agricultural modernization. Driven by digital technologies, digital agriculture in rural areas shows tremendous development potential, huge market demand, and broad application prospects. The era of digital-driven agriculture and rural areas “leapfrogging” is approaching. However, the digital economy empowering high-quality development in agriculture also faces various constraints, such as lagging infrastructure construction, slow development of digital agriculture, insufficient endogenous driving forces, and difficulties in practical applications. To address these issues, the government should increase investment, clarify directions, promote industry academia research collaboration, and strengthen core technologies. These measures will enable the digital economy to better empower the high-quality development of Chinese agriculture.