bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and Implementation of Digital Education Resources Blockchain-Based Authentication System
Authors: Wahyuningsih Tri , Gunawan  , Putri Oganda Fitra , Anggraeni Mey
Published: February 2022

With the approaching of the digital age, digital education resources bring convenience to folks as a result of they're liable to duplicate and spread, however there are some disadvantages in on-line education service transactions. The safety problems with digital education resources and also the development of smuggled distribution seriously harm the rights and interests of the house owners of digital education resources. supported this, during this paper, we have a tendency to planned a blockchain-based digital education resources authentication system that uses the decentralized, tamper-resistant options of blockchain technology to store the digital education resources info within the style of a secret text. Within the system, there is no have to be compelled to need the participation of any third-party institution. The system planned during this study can greatly defend the rights and interests of the owner of digital education resources.
Supply Chain Management, Certificate Management at the Transportation Layer Security in Charge of Security
Authors: Ayuninggati Tsara , Purnama Harahap Eka , Mulyati  , Junior Raihan
Published: February 2022

In the public key infrastructure, the certification authority is fully trusted, and the security of the public key infrastructure depends on the trust of the certification authority; however, recent attacks and corruption on the certification authority indicate that the certificate is forged when the certification authority fails . New solutions, blockchain-based public key infrastructure products and registry can repair vulnerabilities in public key infrastructure, especially weaker security systems. Proposals for infrastructure-based public key infrastructure. Public keys are still the target of global attacks. According to the registration of the target victim, it is signed as a temporary public key infrastructure based on the blockchain. High growth rates require permission to use the wallet. To solve this problem, this document introduces an integrated and responsible system for managing security certificates at the transport layer that represents the next generation of public key infrastructure.I merged two new architectures, introduced a new process, and created a registration and CA server. The domain owner has been notified. In supply chain management, the domain certificate signed by the CA is stored on the registration server, and the certificate server and the CA registration server are forwarded to the group that owns the domain. Compared with existing supply chain public key infrastructure products. The above-mentioned blockchain-based public key infrastructure scheme and registry are used for security and governance analysis.
La pandemia y el año que enseñamos por WhatsApp: el recurso tecnológico más utilizado en las secundarias pobres de Bahía Blanca durante el 2020
Authors: Anderete Schwal Mariano
Published: February 2022

La aparición de la Covid-19 en todo el mundo generó un cierre masivo de escuelas durante el año 2020, no obstante, el personal docente continuó enseñando mediante la educación a distancia, adaptando diversas estrategias según sus posibilidades. El presente trabajo analiza las consecuencias educativas de la pandemia en la educación secundaria argentina durante su primer año y cuáles fueron las Tecnologías de la Información y la Comunicación (TIC) utilizadas por los docentes y el alumnado, en un contexto de segregación educativa. La investigación consiste en un estudio descriptivo utilizando un método cualitativo a partir de entrevistas a docentes y directivos de escuelas pertenecientes al nivel secundario de la ciudad de Bahía Blanca, a quienes se les indagó sobre percepciones y experiencias en torno a los distintos métodos tecnológicos de educación utilizados durante el año escolar 2020. Los resultados de la investigación dan cuenta de una relación entre las condiciones socioeconómicas del alumnado y las herramientas utilizadas por sus profesores. En especial se destaca el uso de la aplicación WhatsApp, la cual se reduce a la única tecnología disponible para la mayoría de los estudiantes que concurren a los colegios secundarios más pobres, ya que para ellos el celular fue su único medio de conexión educativa.
Lo que la pandemia nos quitó: relatos de estudiantes con discapacidad intelectual en tiempos de COVID-19
Authors: Schwamberger Cintia
Published: February 2022

El presente artículo tiene como objetivo relatar la experiencia de estudiantes con discapacidad intelectual en escuelas secundarias emplazadas en contexto de pobreza urbana de la Región Metropolitana de Buenos Aires. Desde una metodología cualitativa nos centramos en las voces de dos estudiantes que narran su experiencia escolar en tiempos de confinamiento. Sostenemos que se vuelve clave recuperar las voces de quienes son destinatarios de las políticas de inclusión que asumen, en tiempos de neoliberalismo recargado, una práctica cosmética como forma de solapamiento de las desigualdades que viven a diario las personas con discapacidad. En rigor, esto no es nuevo, sino que, los efectos y afectos de las políticas profundizaron las marcas de exclusión que vivió el colectivo en tiempos de COVID-19. Esta situación conduce a la necesidad de analizar y poner en discusión las condiciones materiales que habitan y cómo se desarrolla la escolaridad. En los relatos se evidencian las tensiones atravesadas, en tiempos de cuarentena, en tanto que obstáculos, pero, a la vez, de distintas prácticas que les permitió desplegar sus potencias y habilidades.
A Case Report of Unilateral Pediatric Cataract Surgery: Posterior Capsule Opacification and Visual Rehabilitation
Authors: Estu Yulia Dian , Inno Luminta Ferdinand
Published: February 2022

Objective: To report a case of posterior capsule opacification (PCO) and severe deprivation amblyopia following unilateral pediatric cataract surgery
Case Presentation: A 4-year-old girl presented with PCO of the right eye with a history of unilateral congenital cataract surgery and intraocular lens (IOL) implantation without optimal visual rehabilitation two years ago at another hospital in Jakarta. Her uncorrected right eye visual acuity was 3/60 and corrected left eye visual acuity 6/7.5. We performed secondary posterior capsulotomy and anterior vitrectomy of the right eye. Following the procedure, the patient did not regain her vision despite normal posterior segment; thus, a diagnosis of deprivation amblyopia was made. She was prescribed occlusion therapy for 6 hours a day on the left eye to decrease the degree of amblyopia of her right eye.
Conclusion: Early identification and management of pediatric cataract surgery complications combined with optimal visual rehabilitation may benefit the patient in the long run. If not treated properly, especially in unilateral cataract cases, it may be too late to regain visual function.
Management of Bilateral Complicated Cataract in Convalescent Stage of Vogt- Koyanagi-Harada Syndrome
Authors: R. Quamila Faradina , Sofia Ovi , Sulistya T. Budi
Published: February 2022

Introduction: The incidence of complicated cataract in VKH syndrome in Japan is 35% and 40% in US. Cataract extraction surgery is advisable for evaluating posterior segment and improving visual acuity. This study is reporting management of bilateral complicated cataract in Vogt-Koyanagi- Harada syndrome convalescent stage under corticosteroid coverage.
Purpose: To report the diagnostic approach and successful management of bilateral complicated cataract in convalescent stage of Vogt-Koyanagi-Harada syndrome

Case Presentation: A 24-year old woman came to the outpatient clinic of Dr. Saiful Anwar Hospital Malang complaining of blurred vision on both eyes which worsen 2 months prior to visit. It was accompanied with headache, nausea, fever, hair loss, and facial hair whitening started 1 month afterwards. General examination showed alopecia and poliosis. The visual acuity of both eyes were hand motion. Anterior segment examination showed polymorphic old KPs, 4+ flare and 4+ cells, secluded pupil, and cataract in both eyes. Vitritis and choroidal thickening were noted from ultrasound examination. Laboratory examination results were within normal limit. She was diagnosed with Vogt- Koyanagi-Harada syndrome convalescent stage with complicated cataract and had been treated with combination of oral corticosteroid and azathioprine. Synechiolysis and cataract extraction of left eye were performed under oral corticosteroid and posterior subtenon triamcinolone injection coverage. There was improvement of visual acuity and controlled inflammation postoperatively.
Conclusion: Significant visual improvement of left eye was shown after cataract extraction surgery under adequate inflammation control preoperatively. There was no relaps of uveitis during 6 months follow up.
Trauma Kimia Okuli Roper-Hall Derajat IV Bilateral
Authors: Tepo Utomo Purjanto , Nur Shinta P Amanda , Dibyasakti Banuaji , Erik Darmawan Nikolaus , Supartoto Agus
Published: February 2022

Introduction : Ocular Chemical Trauma is an emergency case and need immediate treatment . The causes vary from work accident to abuse. Treatment is aimed to minimalize surface abbration and preserve eye normal anatomy and physiology.
Case Presentation : A 31-year-old man presented with bilateral vision loss with history of unknown liquid exposure to both eyes 2 days prior. Visual acuity was light perception on the right eye and hand movement on the left eye. Ophtalmologic examination presents bilateral palpebral spasms with 3rd grade combustion, bilateral conjunctival chemosis with 360 degree limbal ischemia, lateral canthus symblepharon and bilateral corneal haze. The patient was hospitalized for 33 days.
Conclusion : Ocular chemical trauma has a poor visual outcome despite an extensive treament due to damaged limbal stem cell and the following deterioration sequelae.
Prevalensi dan Karakteristik Buta Warna pada Populasi Urban di Jakarta
Authors: Nusanti Syntia , Sidik M.
Published: February 2022

Purpose: To report the prevalence of color blindness in urban population in Jakarta
Methods: This study is a part of the Urban Eye Health Study. Color vision examination was performed using Ishihara on adult and pediatric subjects with 6/6 vision. If incorrect reading was present, the examination was later continued by using Farnsworth Munsell Hue D 15, then proceeded with completing questionnaire.
Results: The pediatric respondents in this study was 435 (6-16 years old). From that number of subjects, 5,97% of children had color blind. Meanwhile, the adult respondents (41-77 years old) in this study was 1040 with 3.26% of respondents had color blind. There were 100% of pediatric respondents diagnosed with congenital color blindness. Eighty-eight point twenty four percent of adult respondents were diagnosed with congenital color blindness while the remaining 11.76% were diagnosed with acquired color blindness.
Conclusions: The prevalence of congenital color blindness in this study was 3,79%, as much as 88,24% from the adult group and 100% from the pediatric group.
Diagnostic Value of Optical Coherence Tomography and Electroretinogram in Early Detection of Ethambutol-Induced Optic Neuropathy
Authors: Syaputra M. Dio , Nusanti Syntia
Published: February 2022

Background: Ethambutol-induced optic neuropathy (EON) is one of the most compelling adverse effect of tuberculosis treatment. Recovery often occur several months after treatment discontinuation. Unfortunately, some studies noted that nearly half of patients still have permanent visual loss. Early detection before clinical symptoms appear is necessary to prevent this devastating adverse effect. Therefore, this review aims to evaluate the diagnostic value of retinal nerve fiber layer (RNFL) thickness and ganglion cell inner plexiform layer (GCIPL) thickness changes with OCT, pattern and multifocal electroretinogram (ERG) changes during ethambutol treatment as early detection of EON.
Methods: A comprehensive search was conducted from electronic databases (PubMed, EBSCO, Google Scholar, and Springerlink) using relevant search terms. Articles from offline resources were also included. Included studies were selected based on predefined inclusion and exclusion criteria.
Result: Three studies reported significant thinning of RNFL after ethambutol initiation. Increased RNFL thickness in patients with EON and subclinical EON found in 3 studies. Significant macular GCPIL thinning was noted in 1 study. One study reported shortening of P50 implicit time and reduced N95 wave amplitude in pattern ERG.
Conclusion: Macular GCIPL thinning suggested to be the first pathological changes detected on patients with ethambutol treatment. It can be concomitant with thickening of peripapillary RNFL and followed by peripapillary RNFL thinning. Pattern ERG may reveal abnormality due to retinal ganglion cell (RGC) dysfunction before RGC loss.
Success Rate of Trabeculectomy in Secondary Glaucoma after Vitrectomy in Kariadi Hospital, Semarang, Central Java
Authors: Maulida Farah , L. Rahmi Fifin , Cahyono Maharani
Published: February 2022

Objectives: Vitrectomy with intravitreal injections of gas or silicone oil is commonly used to treat vitreoretinal diseases such as rhegmatogenous retinal detachment, tractional retinal detachment, and vitreous hemorrhage. Some of these procedure can lead to short-term elevations in intraocular pressure (IOP) and ultimately long-term glaucomatous damage if not treated in a timely manner. Trabeculectomy is a widely performed filtering surgery used in these cases. This study is aimed to define the success rate of trabeculectomy for surgical treatment of secondary glaucoma after vitrectomy in Kariadi Hospital, Semarang, Central Java.
Methods: Retrospective study was conducted in secondary glaucoma after vitrectomy patient who underwent trabeculectomy from November 2014-Januari 2019 in Kariadi Hospital. The secondary data of baseline IOP, 1 week, 2 weeks, 1 month, and 3 months after trabeculectomy is obtained from medical records.
Results: 19 eyes from 19 patients had mean preoperative IOP 35,56 ± 8,40 mmHg, 1 week 21,01 ± 13,83 mmHg, 2 weeks 26,09 ± 11,27 mmHg, 1 month 29,97 ± 13,45 mmHg, and 3 months 25,47 ± 13,43 mmHg. There was significant differences of IOP level in 1 week, 2 weeks, 3 months (p<0.05), and not significant in 1 month (p 0,171). Complete success rate of trabeculectomy in 1 month was 10,5% and 3 months 10,5%. Qualified success rate in 1 month was 15,8% and 3 months 42,1%. Failed in 1 month was 73,7% and 3 month 47,4%.
Conclusions: Trabeculectomy in secondary glaucoma after vitrectomy has low success rate.
Neuropati Optik Traumatik: Gambaran 13 Kasus Berdasarkan Radiologi dan Awitan Terapi Kortikosteroid di Rumah Sakit Cipto Mangunkusumo
Authors: Paramita Wijayati Made , Nusanti Syntia , Sidik M.
Published: February 2022

Introduction and Objection: Traumatic Optic Neuropathy is a rare and potentially vision-threatening condition caused by ocular or head trauma. The optic nerve axons may be damaged either directly or indirectly. The management of traumatic optic neuropathy could be observed, giving steroids or decompression. At center which optic nerve decompression is not routinely performed, high dose steroid is preferred for traumatic optic neuropathy patients. The study aims to analyze characteristics (mean age and gender, onset trauma, most symptom, visual acuity, consensual reflex as a sign), radiology feature, and onset corticosteroid therapy on patient traumatic optic neuropathy.
Methods: This study was a descriptive observational case series which data retrospectively analysis from medical record.

Result: From 13 cases most common gender affected were males (76,9%). The mean age group 32.85±14.67 years old with blurry vision and bleeding are the most common symptom, the onset of trauma below 24 hours (76.9%), the initial visual acuity is no light perception and hand movement with a negative consensual reflex (76.9%). Visual acuity improves with initial corticosteroid therapy below 24 hours are 7 cases and more than 24 hours are 2 cases. From 9 cases with visual acuity improvement, there are 4 cases with orbital fracture and 5 cases without orbital fracture.
Conclusion: Visual improvement in our cases happened more on initial corticosteroid therapy more than 24 hours and no orbital fracture.
MU Net: Ovarian Follicle Segmentation Using Modified U-Net Architecture
Authors:   Department of Computer Science, University of Gour Banga, Malda, Pin- 732103, West Bengal, India, Saha Debasmita , Mandal Dr. Ardhendu ,   Department of Computer Science and Application, University of North Bengal, Siliguri, West Bengal, Pin-734013, India., Ghosh Rinku ,   Department of Computer Science, University of Gour Banga, Malda, Pin- 732103, West Bengal, India
Published: February 2022

Ovaries play a pivotal role in production by generating eggs through oogenesis in the female reproductive system. This is one crucial aspect of reproduction as eggs are fertilized by the sperm which eventually leads to fertilization and eventually ending in embryo formation. Ovaries are often susceptible to diseases like infertility, polycystic ovarian syndrome (PCOS), ovarian cancer etc. Screening of ovarian follicles via ultrasound images can be of great help in the diagnosis of these abnormal situations. However, screening in most scenarios is still carried out manually by doctors and sonographers leading it to be a monotonous, time consuming and laborious job as well. Thus automatic detection of follicles can reduce the burden of doctors. In our work, we propose MU-net, a novel 2D segmentation network, combination of both MobileNetV2 and U-Net for segmentation of the follicles from ovarian ultrasound images. The test is conducted on the USOVA3D Training Set 1. Although low contrast issues are common setback for ultrasound images, our model has achieved a descent accuracy rate of 98.4%.
Trust Prediction: Use of Decision Tree in Training & Evaluation
Authors:   Professor, Department of Information Technology, Jagan Institute of Management Studies, New Delhi, India, Saxena Dr. Archana B , Sharma Dr. Deepti ,   Associate Professor, Department of Information Technology, Jagan Institute of Management Studies, New Delhi, India., Aggarwal Dr. Deepshikha ,   Professor, Department of Information Technology, Jagan Institute of Management Studies, New Delhi, India.
Published: February 2022

The growth of Cloud Computing is the outcome of numerous benefits associated with this technology. Like: Reduce Energy consumption, waste & carbon emission and affluence & Comfort of its working apparatus. At the same point of time its security concern is making vibrations in the research Community and regulating organizations to find the means of making it a secure and reliable stream where consumers’ interests are ensured & protected. More uncertainty arises in this sector, when data theft cases are cracked up and consumers have compromised some confidential details due to intentional or unintentional action of Cloud providers. It leads the need of Trust evaluation of the provider. This trust evaluation should be in the quantitative terms and completed before selection & registration with the provider for cloud services. This paper is using predictive modeling technique to predict the trust level of the provider. Classification, a supervised Machine Learning technique that uses certification attainment status of the provider to predict its trust level.
Effect of financial capability on customer relationship management in private hospitals in Kenya
Authors: Muthigah Faithmercy Wanyi , Kiragu David , Sang Anne
Published: February 2022

The purpose of this study was to establish the effect of financial capability on customer relationship management in private hospitals in Kenya. The study adopted descriptive survey design. It targeted 161 private hospitals which are accredited by NHIF in Kenya and which formed the unit of analysis of the study. Simple random sampling was then be used to obtain the 644 respondents. The researcher utilized a structured questionnaire with a five-point Likert scale to gather the data. The collected data was coded and entered in SPSS for further analysis. Descriptive and inferential analysis was conducted. The findings indicate there was a statistical and significant relationship between financial capabilities and customer relationship management. Financial capabilities explained 48.5% of the variability in customer relationship management in private hospitals. Hospitals should plan ahead forecast on financial emerging issues to avoid financial distress. Good governance is critical in an organization because it enables flexible adjustments to the emerging spending patterns as strategic demands arise.
Drop Noise For CTR Prediction
Authors: Guo Tong
Published: February 2022

Click-through rate (CTR) prediction is task to estimate the
possibility of user clicking on a recommended item. The ground truth
labels of this task are the click history of users. As there are many reasons
why noise data or low quality data may be generated, the training data
has a certain amount of noise data or low quality data. In this work,
We propose a simple but effective method to find the noise data. Our
method could improve the offline AUC from 0.60 to 0.75 on our realworld dataset.
Unsur penyalahgunaan wewenang oleh Pejabat pemerintahan
Authors: Nur Ainun Azizah Tanti
Published: February 2022

Pejabat Pemerintah adalah seseorang yang melaksanakan fungsi dari Pemerintahan, baik di lingkungan pemerintahan maupun penyelenggara negara. Untuk itu, pejabat pemerintah dilarang membuat suatu keputusan di luar ruang lingkup pekerjaan yang seharunya atau tindakan penetapan dalam pemerintahan yang berpotensi dapat menimbulkan sautu konflik kepentingan dalam Pemerintahan serta kerugian-kerugian yang ditujukan ke negara. Seperti membuat kerugian yang berdampak kepada keuangan negara dan penyalahgunaan kewenangan lainnya yang dibuat secara sengaja. Berkaitan dengan hal tersebut, terdapat aturan larangan penyalahgunaan wewenang pejabat pemerintahan. Larangan penyalahgunaan wewenang tersebut meliputi larangan untuk melampaui batasan wewenang, larangan bertindak demi kepentingan pribadi maupun kerabat dekat, dan atau larangan bertindak sewenang-wenang di luar kapasitasnya. Dalam hal ini Pejabat Pemerintah yang seharusnya melaksanakan fungsi dari Pemerintahan itu sendiri apabila menyalahgunakan kewenangan dalam jabatannya akan sangat menimbulkan kerugian bagi negara.Tujuan dilakukannya penulisan makalah ini yaitu untuk mengetahui lebih jelas sejauh apa tugas dan wewenang dari Pejabat Pemerintah. Metode yang digunakan dalam penulisan ini menggunakan metode yuridis normatif (metode penelitian hukum normatif).
Analisis Pengaruh Kualitas Sistem Informasi, Kualitas Informasi dan Perceived Usefulness Terhadap Kepuasan Pengguna Aplikasi Olibsifrs (Psak) 71 (Studi pada Bank Papua)
Authors: Arvianto Vicky , Usino Wendi
Published: February 2022

Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh Kualitas Sistem Informasi, Kualitas Informasi dan Perceived Usefulness terhadap Kepuasan Pengguna aplikasi OlibsIFRS (PSAK) 71 di PT. Bank Papua. Penelitian mengadopsi model kesuksesan sistem informasi DeLone dan McLean yang dikombinasikan dengan model kesuksesan sistem informasi Seddon dan dikolaborasikan dengan metode penelitian kuantitatif. Sampel dalam penelitian ini ditentukan dengan teknik Purposive Sampling dengan metode pengumpulan data dilakukan dengan menggunakan kuesioner google form. Jumlah sampel yang digunakan dalam yaitu sebanyak 52 orang yang merupakan karyawan pengguna aplikasi OlibsIFRS (PSAK) 71 di PT. Bank Papua. Metode untuk melakukan pengolahan dan analisis data menggunakan Partial Least Square (PLS) dengan bantuan software SmartPLS. Hasil penelitian menunjukan bahwa Kualitas Sistem tidak berpengaruh signifikan dengan kontribusi sebesar 5,1% terhadap Kepuasan Pengguna, Kualitas Informasi berpengaruh signifikan dengan kontribusi sebesar 26,0% terhadap Kepuasan Pengguna dan Perceived Usefulness berpengaruh signifikan dengan kontribusi sebesar 67,9% terhadap Kepuasan Pengguna aplikasi OlibsIFRS (PSAK) 71 di PT. Bank Papua. Secara simultan variabel Kualitas Sistem, Kualitas Informasi dan Perceived Usefulness membentuk R-square senilai 0,846 hal ini menandakan variabel Kualitas Sistem, Kualitas Informasi dan Perceived Usefulness dari setiap indikator masing-masing variabel secara bersama-sama memberikan pengaruh korelasi yang kuat/signifikan terhadap variabel Kepuasan Pengguna sebesar 84,6%, sedangkan sisanya sebesar 15,4% dijelaskan oleh variabel dan indikator lain yang tidak dimasukan dalam model penelitian.
MODERN INTERNET MARKETING TOOLS
Authors:   North-Ossetian State University named after K. L. Khetagurov, Vladikavkaz, Russia, Bekmurzaeva Zarina Kh. , Doev Z. K. ,   North-Ossetian State University named after K. L. Khetagurov, Vladikavkaz, Russia
Published: February 2022

The concept of Internet marketing is considered. The classification of methods and tools of Internet marketing is given, the modern and most widely used methods in practice are detailed, the advantages and disadvantages of each method are described. Recommendations are given for the effective application of Internet marketing methods in the activities of a modern company.
ASSESSMENT OF THE PERFORMANCE OF SYSTEMICALLY IMPORTANT BANKS
Authors:   Azerbaijan State University of Economics, Baku, Azerbaijan, Mammedli Aynur G.
Published: February 2022

The study attempts to evaluate Turkish banks in accordance with their systemic significance using the author's method. The levels of systemic significance of institutions in the sample were determined by public financial statements for 2012. Banks were grouped after cluster analysis. The review is repeated by weighing the categories of banks at different rates to see the impact of each category on systemic significance.
CORPORATE SOCIAL RESPONSIBILITY: CURRENT STATUS AND DEVELOPMENT PROSPECTS
Authors:   Financial University under the Government of the Russian Federation, Moscow, Russia, Matevosyan Laura M. , Scherbachenko Petr S. ,   Financial University under the Government of the Russian Federation, Moscow, Russia
Published: February 2022

The article provides a brief description of the main approaches to understanding the essence of corporate social responsibility, describes its key models and the current state in large Russian and foreign corporations. Socially significant issues are coming to the fore, and now business activities should be aimed not only at satisfying economic interests, but also at respecting the rights of citizens, achieving sustainable development goals, which in recent years have become the standard of humanism.
DAIRY INDUSTRY COST MANAGEMENT MODEL
Authors:   Novgorod State University named after Yaroslav the Wise, Veliky Novgorod, Russia, Burova Irina A.
Published: February 2022

The author presents an approach to the development of a cost management model for organizations operating in the dairy industry. The basis for the development of a management model is the differentiation of cost management objects by management levels. The strategic, tactical and operational management levels are singled out, for each of which the characteristics of the main management processes are presented, the applied management tools are listed.
Información sobre Tesis doctorales
Authors: Martín-Consuegra Ávila Fernando , Escudero-Boyero David
Published: February 2022

- Análisis de datos espaciales para la erradicación de la pobreza energética en la rehabilitación urbana. El caso de Madrid

- Más allá de la cinematografía: En busca de una arquitectura neorrealista en Italia, 194X-195X
Territorio, ciudad y hábitat en el PGOU de Málaga 2011: actividad agraria y planeamiento urbano de Los Montes de Málaga
Authors: Gómez-Moreno María Luisa
Published: February 2022

La aplicación del análisis geográfico regional a la construcción social del territorio permite conocer y reorientar las relaciones rural-urbanas, y por ello puede ser un instrumento adecuado para la integración de la multifuncionalidad agraria en el planeamiento urbanístico municipal. El objetivo de este artículo es analizar esta integración en el tratamiento de los Montes de Málaga por el Plan General de Ordenación Urbana de Málaga de 2011. Para ello, se sintetiza esta construcción mediante bibliografía; se revisa la epistemología dedicada a la consideración de la multifuncionalidad agraria por el planeamiento urbanístico, y finalmente, se analiza la normativa de dicho PGOU aplicada a los Montes. Las conclusiones revelan que el PGOU subordina la multifuncionalidad agraria de los Montes a la protección de sus valores ambientales y estéticos, en detrimento de una articulación campo-ciudad basada en la complementariedad de sus funciones (agricultura de proximidad).
Blockchain Use Cases Against Climate Destruction
Authors: Thalhammer Felix , Schöttle Pascal , Janetschek Matthias , Ploder Christian
Published: February 2022

Based on the current measures, it is unlikely that the targets of the Paris Agreement on climate change are to be achieved within the given time. Therefore, new solutions are needed to get climate change under control. Emerging technologies like blockchain allow for new ways to approach climate change. The blockchain serves only as an enabling technology for cryptocurrencies but is a stand-alone tool applicable for various purposes. This paper aims to shed light on the overlap between the areas of blockchain and climate change. Research in this area was examined for potential blockchain use cases to support climate action using a systematic literature review. The found applications can be grouped into the main categories of Emissions Trading and Green Certificates, Sustainable Energy, Sustainable Mobility, and Green Financing. Within these applications, blockchains are being used as supporting technology. Especially transparency, traceability, and immutability are particularly beneficial in blockchain-based applications against climate change. As a downside of the technology, controversial aspects of the blockchain are considered as the energy consumption of the technology.
Likable or Authentic? Perspectives of Locals and Tourists in Food Event Experience
Authors: Hazel Xu Yueying , Christy Ng Yen Nee , Tan Xiuchang , Wu Chiwai Don
Published: February 2022

With the growing appetite of appreciating local gastronomy and the need of destination branding for culinary tourism, food events have become increasingly popular in many cities. Authenticity has long been recognized as one important factor to evaluate food-related experience; however,
the likability of food is rarely examined. The study gives a first attempt to include food likability, a hedonic perspective, together with authenticity, in evaluating food and event experience at a food festival. A valid sample of 447 event attendees was recruited from Macao's Local Culture
& Food Festival. The findings show that food likability and food authenticity significantly influence the perception of culinary event authenticity that further leads to event satisfaction. Differences between local attendees and tourists regarding food evaluation and their event experiences
are also examined. Implications of the findings are discussed and suggestions for future study are provided.
New antibody-drug conjugates (ADCs) in breast cancer—an overview of ADCs recently approved and in later stages of development
Authors: Koster Kira-Lee , Huober Jens , Joerger Markus
Published: February 2022

Antibody-drug conjugates (ADCs) have changed the treatment of breast cancer (BC) in more recent years. BC is a heterogenous group of malignancies with a broad range of histopathological characteristics. ADCs represent a class of therapeutics that combines an antigen-specific antibody backbone bound to a potent cytotoxic agent (the payload), via a linker, contributing to an improved therapeutic index. Currently, three ADCs received approval by the US Food and Drug Administration (FDA) and are in routine clinical use in different treatment settings; many more ADCs are in earlier and later stages of development, and their future approval will improve treatment options for patients with advanced but potentially also early-stage BC over time. Just recently, the results of three phase 3 trials (ASCENT, TULIP, and DESTINY-Breast03) evaluating sacituzumab govitecan (SG), trastuzumab duocarmazine, and trastuzumab deruxtecan (T-DXd) in different treatment settings were presented and showed promising results. This overview focuses on the newer ADCs, including T-DXd and SG, their pharmacology, mechanisms of action, and relevant studies. In addition, the latest results from trials investigating some newer ADCs, in further stages of development are presented.
B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells
Authors: Minton Annabel , Smith Lindsay , Bryant Dean , Strefford Jonathan , Forconi Francesco , Stevenson Freda , Tumbarello David , James Edd , Løset Geir , Munthe Ludvig , Steele Andrew , Packham Graham
Published: February 2022

Aim: T-helper cells could play an important role in the pathogenesis of chronic lymphocytic leukemia (CLL), a common B-cell neoplasm. Although CLL cells can present soluble antigens targeted from the B-cell receptor to T-helper cells via major histocompatibility complex (MHC) class II, antigens recognized by some CLL cells may be encountered in a particulate form. Here the ability of CLL cells to internalize and present anti-immunoglobulin M (IgM) beads as a model for the interaction of CLL cells with particulate antigens was investigated. Methods: The effect of anti-IgM beads on antigen presentation pathways was analyzed using RNA-seq and internalization of anti-IgM beads by primary CLL cells was investigated using confocal microscopy and flow cytometry. Antigen presentation was investigated by analyzing activation of a T-cell line expressing a T-cell receptor specific for a peptide derived from mouse κ light chains after incubating CLL cells with a mouse κ light chain-containing anti-IgM monoclonal antibody. Kinase inhibitors were used to characterize the pathways mediating internalization and antigen presentation. Results: Stimulation of surface IgM of CLL cells increased expression of the antigen presentation machinery and CLL cells were able to phagocytose anti-IgM beads. Internalization of anti-IgM beads was associated with MHC class II-restricted activation of cognate T-helper cells. Antigen presentation by CLL cells was dependent on activity of spleen tyrosine kinase (SYK) and phosphatidylinositol 3-kinase delta (PI3Kδ) but was unaffected by inhibitors of Bruton’s tyrosine kinase (BTK). Conclusions: CLL cells can internalize and present antigen from anti-IgM beads. This capacity of CLL cells may be particularly important for recruitment of T-cell help in vivo in response to particulate antigens.
Engineered phosphorus dendrimers as powerful non-viral nanoplatforms for gene delivery: a great hope for the future of cancer therapeutics
Authors: Mignani Serge , Shi Xiangyang , Bryszewska Maria , Shcharbin Dzmitry , Majoral Jean-Pierre
Published: February 2022

During the past two decades, tremendous progress has been made in the dendrimer-based delivery of therapeutic molecules including, for instance, small molecules, macromolecules, and genes. This review deals with recent successes in the development of promising biocompatible phosphorus dendrimers, a specific type of dendrimer, to deliver genes to treat cancers.
Amblyomma cajennense (Fabricius, 1787) (Ixodida: Ixodidae): human parasitism and the first record from the Acre State, Western Brazilian Amazon
Authors: Souza Vanessa L. de , Lima Marcos S. de , Martins Thiago F. , Costa Franscio E. da , Silva José R. O. da , Souza José R. L. de
Published: February 2022

The Cayenne tick, Amblyomma cajennense (Fabricius, 1787) (Ixodida: Ixodidae), parasitizes a range of vertebrate hosts, including humans, accidentally. Infestation by this species has important implications for public health, given that these ticks habitually bite humans and may act as the vectors of several pathogens. Here, we present a detailed case of human parasitism by A. cajennense and provide the first record of the occurrence of the species in the state of Acre, Brazil.
Dissociating sub-processes of aftereffects of completed intentions and costs to the ongoing task in prospective memory: A mouse-tracking approach
Authors: Kurtz Marcel , Scherbaum Stefan , Walser Moritz , Kanske Philipp , Möschl Marcus
Published: February 2022

In the present study, we used mouse tracking to investigate two processes underlying prospective memory (PM) retrieval: First, we aimed to explore to what extent spontaneous retrieval of already completed PM intentions is supported by reflexive-associative and discrepancy-plus-search processes. Second, we aimed to disentangle whether costs to an ongoing task during the pursuit of a PM intention are associated with presumably resource-demanding monitoring processes or with a presumably resource-sparing strategic delay of ongoing-task responses. Our third aim was to explore the interaction of processes underlying costs to the ongoing task and processes of spontaneous retrieval. Our analyses replicated response-time patterns from previous studies indicating aftereffects of completed intentions and costs to ongoing-task performance, as well as increased aftereffects while pursuing a PM intention. Notably, based on our mouse-tracking analyses, we argue that aftereffects of completed intentions are best explained by a reflexive initiation of an already completed intention. If the completed intention is not performed in its entirety (i.e., no commission error), the reflexive initiation of the completed intention is followed by a subsequent movement correction that most likely represents a time-consuming response-verification process. Regarding performance costs in the ongoing task, our analyses suggest that actively pursuing a PM intention most likely leads to a strategic delay of ongoing activities. Lastly, we found that pursuing a novel PM task after intention completion exacerbated orienting responses to all deviant stimuli, exacerbated the readiness to initiate the completed intention reflexively, and substantially prolonged the response-verification process following this reflexive intention retrieval.
Parafoveal processing of repeated words during reading
Authors: Drieghe Denis , Chan Seem Robert
Published: February 2022

In an eye-tracking experiment during reading, we examined the repetition effect, whereby words that are repeated in the same paragraph receive shorter fixation durations. Target words that were either high-frequency or low-frequency words and of which the parafoveal preview was either correct or with all letters replaced were embedded three times in the same paragraph. Shorter fixation times and higher skipping rates were observed for high-frequency compared to low-frequency words, words for which the parafoveal preview was correct versus incorrect, and as the word was being repeated more often. An interaction between frequency and repetition indicated that the reduction in fixation times due to repetition was more pronounced for low-frequency words. We also observed influences of word repetition on parafoveal processing, as repeated words were skipped more often. An interaction between parafoveal preview and repetition indicated an absent repetition effect when the preview was incorrect, but this effect was short lived, as it was restricted to the first fixation duration on the target word.
Measuring national mood with music: using machine learning to construct a measure of national valence from audio data
Authors: Benetos Emmanouil , Ragano Alessandro , Sgroi Daniel , Tuckwell Anthony
Published: February 2022

We propose a new measure of national valence based on the emotional content of a country’s most popular songs. We first trained a machine learning model using 191 different audio features embedded within music and use this model to construct a long-run valence index for the UK. This index correlates strongly and significantly with survey-based life satisfaction and outperforms an equivalent text-based measure. Our methods have the potential to be applied widely and to provide a solution to the severe lack of historical time-series data on psychological well-being.
Patrones alimentarios y estado nutricional en niños con síndrome de Down en Posadas (Misiones Argentina)
Authors: Ghiglione Ornella Vanesa , López Andrea Roxana
Published: February 2022

El presente estudio se desarrolló en diferentes instituciones de educación especial en la ciudad de Posadas (Misiones, Argentina) en el periodo agosto-septiembre del 2017. El objetivo del estudio es evaluar el estado nutricional y los patrones alimentarios en niños de 2 a 12 años con síndrome de Down. El estudio es correlacional de corte transversal. Para la toma de medidas antropométricas, se utilizó una balanza de precisión o báscula de pie y un estadiómetro portátil. Para establecer el patrón alimentario, se realizó una frecuencia de consumo de elaboración propia y el tamizaje de Block. Se incluyeron 30 niños, el 57% del género masculino y el 43% del género femenino. Se evidenció, utilizando graficas específicas para síndrome de Down de la Fundación Catalana, que el 63,33% presenta obesidad; el 53%, un exceso de peso para la edad; y el 50% no sigue con un crecimiento lineal normal, e indica talla baja para la edad. En cuanto a la frecuencia de consumo, se identificó un bajo consumo de vegetales y una elevada ingesta de harinas refinadas y alimentos fuente de carbohidratos simples (bebidas azucaradas y postres), grasa saturada y colesterol. El cuestionario de tamizaje de Block para el consumo de grasas mostró que un 46,66 % obtuvo un puntaje mayor a 27, lo que indica una dieta muy alta en grasas. Para el consumo de verduras, frutas y fibra, un 46,66% recibió un puntaje menor a 20, lo que corresponde a una dieta baja en nutrientes importantes. A partir de los resultados obtenidos, se concluye que existe una correlación significativa entre la obesidad y el patrón alimentario predominante.

Palabras claves: síndrome de Down, estado nutricional, patrón alimentario
Cambios en la alimentación durante el aislamiento por COVID-19: una experiencia de curricularizar la investigación
Authors: Monteverde Ana Clara , Naef Elisa Fernanda , Peruzzo Laura Melina , Eckerdt María Consuelo , Clerici Carolina
Published: February 2022

En este artículo se comparten los resultados de una investigación en el marco de una experiencia de curricularización de la investigación con estudiantes de la cátedra Metodología de la Investigación II, del tercer año de la carrera de Licenciatura en Nutrición durante el año 2020. Se realizó un diseño combinado con un primer abordaje cualitativo de análisis de entrevistas en profundidad realizadas a partir de plataformas virtuales utilizando el Método Comparativo Constante, que permitió construir categorías que, en un segundo momento de abordaje cuantitativo, se operacionalizaron en una encuesta aplicada a partir de un formulario de Google FormsⓇ que se analizó estadísticamente, a fin de validarlas en la mayor cantidad de casos. Los resultados muestran que la alimentación fue uno de los aspectos que se modificó durante el período de aislamiento, para convertirse en un fenómeno multicausal. En la primera etapa del ASPO, se llevaron a cabo prácticas poco saludables por la ansiedad producto del encierro y la modificación de la rutina debido a la virtualidad del estudio y el trabajo. Luego de los primeros meses del ASPO, se visualizan cambios positivos (mejorar la planificación de menús, incorporar nuevas preparaciones saludables a partir de la realización de comidas caseras), situación que ocasionalmente implicó cambios negativos por la presencia de alimentos ultraprocesados de alto valor calórico. El 49% manifestó que estos cambios se produjeron en los primeros meses del ASPO y luego volvió a la situación pre-ASPO, mientras que en un 48% se dio al principio y se sostuvo en el tiempo.

Palabras clave: curricularización, investigación, alimentación, pandemia
Locating the CSM Emission within the Type Ia Supernova Remnant N103B
Authors: Guest Benson T. , Blair William P. , Borkowski Kazimierz J. , Ghavamian Parviz , Hendrick Sean P. , Long Knox S. , Petre Robert , Raymond John C. , Rest Armin , Sankrit Ravi , Seitenzahl Ivo R. , Williams Brian J.
Published: February 2022

We present results from deep Chandra observations of the young Type Ia supernova remnant (SNR) 0509–68.7, also known as N103B, located in the Large Magellanic Cloud (LMC). The remnant displays an asymmetry in brightness, with the western hemisphere appearing significantly brighter than the eastern one. Previous multiwavelength observations have attributed the difference to a density gradient and suggested origins in circumstellar material, drawing similarities to Kepler’s SNR. We apply a clustering technique combined with traditional imaging analysis to spatially locate various emission components within the remnant. We find that O and Mg emission is strongest along the blast wave, and coincides with Spitzer observations of dust emission and optical emission from the nonradiative shocks. The abundances of O and Mg in these regions are enhanced relative to the average LMC abundances and appear as a distinct spatial distribution compared to the ejecta products, supporting the interpretation based on a circumstellar medium. We also find that the spatial distribution of Cr is identical to that of Fe in the interior of the remnant, and does not coincide at all with the O and Mg emission.
Analyzing Star Formation Feedback Mechanisms in Cosmological Simulations
Authors: Fush S. Trevor , O’Shea Brian W. , Silvia Devin W. , Smith Britton D. , Wise John H.
Published: February 2022

This study analyzes 18 simulated galaxies run using three prescriptions for stellar feedback, including thermal, kinetic, and interstellar medium pre-processing feedback mechanisms. Each simulation set models one of these mechanisms with 6 distinct galaxies, with varying M
vir at z = 0. The morphological and thermodynamic quantities and distributions, as well as star formation histories, are compared to understand the impact of each stellar feedback mechanism. We find that the prescription for stellar feedback makes a significant impact on the behavior of galaxies, and observe systematic trends within each simulation and across mass ranges. Specifically, kinetic feedback results in no formation of a disk structure and delayed star formation, and pre-processing of the interstellar medium results in delayed star formation as compared to the thermal feedback mechanisms.