bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploration of the Two-Way Adjustment Mechanism of Rhei Radix et Rhizoma for Cardiovascular Diseases
Authors: Pei Lishan , Shen Xia , Qu Kai , Tan Conge , Zou Junbo , Wang Yanxia , Ping Fan
Published: May 2020

Aim and Objective:

Myocardial infarction, cerebral infarction, and other diseases
caused by vascular obstruction have always jeopardized human life and health. Several reports
indicate that Rhei Radix et Rhizoma has a good clinical effect in the prevention and treatment of
cardiovascular diseases. Owing to the complexity of herbal medicine, the pharmacodynamic
mechanism of Rhei Radix et Rhizoma is still unclear. The objectives of this study were to explore
the two-way adjustment mechanism of Rhei Radix et Rhizoma and provide a new solution for the
prevention and treatment of cardiovascular disease.

Materials and Methods:

This study used data mining, reverse pharmacophore matching, network
construction, GO and KEGG Analysis, and molecular docking to investigate the two-way
adjustment mechanism of Rhei Radix et Rhizoma. The methods used were based on systems
pharmacology and big data analysis technology.

Results:

The results suggest that Rhei Radix et Rhizoma uses a two-way adjustment of activating
blood circulation, as well as blood coagulation in the prevention and treatment of cardiovascular
diseases. The components involved in activating blood circulation are mainly anthraquinone
components. The corresponding targets are NOS2, NOS3, CALM1, and the corresponding
pathways are calcium signaling pathway, VEGF signaling pathway, platelet activation, and the
PI3K-Akt signaling pathway. For blood coagulation, the components are mainly tannin
components; the corresponding targets are F2, F10, ELANE, and the corresponding pathways are
the neuroactive ligand-receptor interaction, complement and coagulation cascades.

Conclusion:

This study indicated that Rhei Radix et Rhizoma exerts the two-way adjustment of
activating blood circulation and blood coagulation in the prevention and treatment of
cardiovascular diseases. It can make up for the side effects of the existing blood circulation drugs
for cardiovascular disease, only activating blood circulation, and the uncontrollable large-area
bleeding due to the long-term use of the drugs. This study provides a material basis for the
development of new blood-activating drugs based on natural medicine.
Flaxseed for Health and Disease: Review of Clinical Trials
Authors: Shayan Mersedeh , Kamalian Safa , Sahebkar Amirhossein , Tayarani-Najaran Zahra
Published: May 2020

Background:

Flaxseed (Linum usitatissimum) is an oil-based seed that contains high
amounts of alpha-linolenic acid, linoleic acid, lignans, fiber and many other bioactive components
which is suggested for a healthier life. Nowadays, flaxseed is known as a remarkable functional
food with different health benefits for humans and protects against cardiovascular disease,
diabetes, dyslipidemia, obesity and altogether metabolic syndrome.

Methods:

To review the bioactive components of flaxseed and their potential health effects,
PubMed and Scopus were searched from commencement to July 2019. Keywords including:
"flaxseed", "Linum usitatissimum", "metabolic syndrome", "obesity", "inflammation", "insulin
resistance", "diabetes", "hyperlipidemia" and "menopause" were searched in the databases with
varying combinations.

Conclusions:

Consumption of flaxseed in different forms has valuable effects and protects against
cardiovascular disease, hypertension, diabetes, dyslipidemia, inflammation and some other
complications. Flaxseed can serve as a promising candidate for the management of metabolic
syndrome to control blood lipid levels, fasting blood sugar, insulin resistance, body weight, waist
circumference, body mass and blood pressure.
Preparation of A Magnetic Nanosensor Based on Cobalt Ferrite Nanoparticles for The Electrochemical Determination of Methyldopa in The Presence of Uric Acid
Authors: Najafi Khadijeh , Asadpour-Zeynali Karim , Mollarasouli Fariba
Published: May 2020

Aim and Objective:

Methyldopa is one of the medications that is used for the treatment
of hypertension. Therefore, the determination of methyldopa in the presence of other biological
components is essential. In this work, a promising electrochemical sensor based on CoFe2O4
magnetic nanoparticles modified glassy carbon electrode (CoFe2O4/GCE) was developed for
electrochemical determination of methyldopa in the presence of uric acid. Cobalt ferrite
nanoparticles were synthesized via chemical method.

Materials and Methods:

Characterizing the CoFe2O4 was investigated by field emission scanning
electron microscopy (FESEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy
(EDX), transmission electron microscope (TEM), and cyclic voltammetry techniques.

Results:

Under the optimal experimental conditions, the current response of the electrochemical
sensor obtained with differential pulse voltammetry was increased linearly in the concentration
range from 1.45 to 15.1 μmol L−1 with the detection limit of 1.07 μmol L−1 for methyldopa. Also,
by using the proposed method, methyldopa and uric acid could be analyzed in a mixture
independently. The difference in peak potential for analytes is about 150 mV.

Conclusion:

The present sensor was successfully applied for the determination of methyldopa in
the presence of uric acid in biological samples and the pharmaceutical samples with satisfactory
results.
Risk Factors of Preeclampsia among Pregnant Women in Khorramabad (West of Iran)
Authors: Mardani Mahnaz , Teymouri Farshad , Rezapour Maryam
Published: May 2020

Background:

Preeclampsia occurs in 2-10% of pregnancies, worldwide, and is characterized
as a combination of hypertension and proteinuria.

Objective:

The purpose of this study is to determine the risk factors associated with the incidence of
preeclampsia in the west of Iran and associated factors.

Methods:

This is a cross sectional study that was performed on 740 pregnant women between 2014-
2017, who were referred to different health care centers of Khorramabad. The data was collected
from these centers and a questionnaire was filled for every woman that included age, height, gender
of the neonate, number of pregnancies, multiparity, season of the pregnancy, birth weight, mothers’
body mass index (BMI) before delivery, smoking history and diagnosis of preeclampsia. The data
obtained was statistically analyzed using SPSS software.

Results:

Of the 760 subjects included, 1.1% (8 cases) were reported to be presented with
preeclampsia. We found a significant difference between non pre-eclamptic and pre-eclamptic patients
in terms of BMI (p=0.006), number of pregnancies (p<0.05), maternal age (p<0.05) and
weight (p=0.004). With an increase in BMI and the number of pregnancies, the risk of preeclampsia
was elevated. Pre-eclamptic mothers had higher body weight than non-pre-eclamptic ones (75.9 kg
vs. 65.6 kg) and the prevalence of preeclampsia increased with age.

Conclusion:

The prevalence of preeclampsia was seen to be positively associated with higher BMI,
pregnancy rate, mother weight and age are associated with higher prevalence of preeclampsia.
Potential of Catalytic Ozonation in Treatment of Industrial Textile Wastewater in Indonesia: Review
Authors: Rame Rame
Published: May 2020

Industrial textile wastewater is one of the most heavily polluting in Indonesia. Wastewater from industrial textile contains organic contamination that is very difficult to remove pollutants that remaining even though it has been through the usual wastewater treatment unit installed and bio refractory in nature. Toxic organic compounds discharged from the textile industry, such as colored dyes, heavy metals, and various chemicals, will hurt the environment. These contaminants have been proven toxic to the biotic environment, such as mutagenic, which can increase the incidence of cancer and endocrine disruptor effects. Removal of contaminants from industrial textile wastewater is currently one of the most critical subjects in water pollution prevention. Applications of catalytic ozonation treatment initially, powder catalysts have been employed, and later, the use of activated carbon materials in more advanced catalyst structures reported, and more sophisticated types of catalyst equipment namely carbon nanotube, and nanoparticles. In-depth research on the combination of ozonation and catalytic research of industrial textile wastewater treatment has the potential to become a well-developed approach to treatment industrial textile wastewater. This review provides process principles and characteristics, including the use of various catalysts, variations in reactor design, and application catalytic ozonation in synthetic textile wastewater and real industrial textile wastewater outlined and discussed. Include future research directions of the treatment of industrial textile wastewater in to clean water with drink quality.
Analysis of dual-band matching of an ends-fed dipole-like antenna and a coaxial line
Authors: Alekseytsev S. A. , Gorbachev A. P.
Published: May 2020

The problem of dual/multi-band radiation of a single-body antenna is of a great topicality today when there is a continuing development of wireless communications both for civil and military purposes. The estimation of dual-band performance of endsfed dipole-like radiator, in particular, its matching with a standard purely active resistance coaxial line is given in the paper. The focus was on stating the necessary conditions and requirements on the geometric sizes of the structure under investigation and the frequency range it have to be analyzed through. It is also considered how to decrease amount of calculations needed at the starting stage of the antenna designing that includes the exact analytical approaches for near field calculations. This decrease is based on the difference in the impact the parameters under consideration have on the antenna input impedance. For the crucial electrodynamics characteristics calculations the induced electromotive forces (EMF) method is used, which has established itself as one of the most convenient in this field.
Environmental control methods under anthropogenic influence of additive production
Authors: Chabanenko A. V. , Smirnova V. O.
Published: May 2020

The use of additive technologies ensures the individualization of products, reduces the consumption of raw materials, improves the economic performance of production, allows the use of new materials and composites, as well as improves the quality of products. However, it is necessary to take into account the factors of the anthropogenic impact of additive production on the environment. In additive manufacturing, various types of polymers are used that undergo certification. The environmental certificate ensures that, under normal operating conditions, the polymer product is safe. However, the greatest impact of additive technologies on the environment occurs in the process of polymer melting. The article proposes a method for assessing the environmental friendliness of additive production by analyzing air samples taken at the time of polymer extrusion. A gas chromatographic analysis of air samples obtained by melting several samples of different polymers used in additive production was carried out.
Contributions of physical education teachers’ competences to students’ learning achievements
Authors: Anwar M. Hamid , Rachman Hari Amirullah , Purwanto Joko , Sudardiyono Sudardiyono
Published: May 2020

This study aims to determine whether the competences of Physical Education (PE) teachers make contributions to the quality of learning achievements of elementary school students. It was qualitative descriptive research using a reflective explorative approach. The subject of this study was the result of competence test of PE teachers in Yogyakarta Special Region in 2016. The study involved 60 PE teachers who were subjected to have an FGD (Forum Group Discussion) in some stages. The results show that the average score obtained by elementary school PE teachers in their Teacher Competence Test (TCT) stage II in 2016 was 61.79 for the pedagogical competences, and 60.07 for the professional competences. These results could exceed the national average score of 53.7. Based on the interviews with several teachers, the results of the competence tests had not indicated that PE elementary school teachers could improve the students’ learning quality. The teachers focused more on their preparations to take the TCT as a part of the assignments to the Learning Teacher program they participated in. This study also reveals that the TCT scores did not make a significant contribution to the students’ learning achievements in PE subject. Furthermore, TCT was considered by the teachers as a goal and not as an instrument to improve their competences in the teaching and learning processes.
Исследование структурных особенностей дентина методами микротомографии и просвечивающей электронной микроскопии
Authors: Аргунова Т.С. , Гудкина Ж.В. , Гуткин М.Ю. , Зайцев Д.В. , Калмыков А.Е. , Мясоедов А.В. , Назарова Е.Д. , Панфилов П.Е. , Сорокин Л.М.
Published: May 2020

Dentin of human teeth is a natural composite material with a layered hierarchical structure; it is formed by micro- and nanostructures whose complex relations obey the laws not yet fully understood. In order to understand the effect of the dentin structure on its mechanical properties, a study of dentin samples prepared from human molars and subjected to a uniaxial compression was made. Synchrotron X-ray microtomography and transmission electron microscopy were employed to investigate the elements of dentin matrix and the tubules which cross the matrix. Single structural features based on the interaction of the elements, as well as the properties of the dentinal tubules, which can stop crack propagation have been investigated. A model is proposed for calculating the conditions of stopping of a mode II crack by generation of secondary cracks caused by the stresses over the surfaces of the tubules.
Модельная среда с тепловыми и транспортными свойствами жидкой воды
Authors: Васин А.А. , Волков А.А.
Published: May 2020

A model of a Frenkel gas-solid medium consisting of Н2О molecules and H3O + and OH- ions with the same density and concentration of particles as liquid water is considered. Particles make a thermal vibrational-diffusive motion, during which they collide, exchange protons and interconvert. Under the assumption that the medium is retained by the dipole-ion interaction forces, it was shown that the evaporation enthalpy H, specific heat C, and also the transport parameters of the medium --- self-diffusion coefficient D, viscosity eta, and thermal conductivity theta --- are close to the reference values ​​for liquid water throughout the interval of its existence (250-600 K).
Оптимизация параметров импульсных РЧ-последовательностей для МРТ-исследований в присутствии магнитных наночастиц
Authors: Богачев Ю.В. , Никитина А.В. , Фролов В.В. , Марченко Я.Ю. , Николаев Б.П.
Published: May 2020

The influence of parameters of various pulsed radio frequency (RF) sequences on the contrast of magnetic resonance (MR) images is investigated. A program for modeling of magnetic resonance imaging (MRI) tomograms and determining the optimal values of pulse RF sequences parameters to achieve the best contrast of MR images has been developed. This program has been tested for MRI studies using negative contrast agents based on magnetic iron oxide nanoparticles and positive contrast agents based on gadolinium. Their influence on MR signal intensity depending on concentration is analyzed. Recommendations on the choice of optimal values of RF sequences parameters for MRI diagnostics using contrasting agents are developed.
Изменение содержания оксида азота и меди в печени и гиппокампе крыс после моделирования ишемии головного мозга
Authors: Гайнутдинов Х.Л. , Андрианов В.В. , Яфарова Г.Г. , Базан Л.В. , Богодвид Т.Х. , Пашкевич С.Г. , Досина М.О. , Замаро А.С. , Денисов А.А. , Кульчицкий В.А.
Published: May 2020

Приведены результаты анализа содержания оксида азота и меди в печени и гиппокампе крыс после моделирования ишемии головного мозга. Исследования проведены методом спектроскопии электронного парамагнитного резонанса с использованием методики спиновых ловушек. Было показано, что содержание оксида азота на следующий день после моделирования ишемии мозга в гиппокампе снижалось в среднем на 50%, в тканях печени наблюдалась тенденция к снижению. Через два дня после моделирования ишемии головного мозга содержание оксида азота в гиппокампе восстанавливалось, в печени наблюдалось достоверное увеличение в среднем на 46% относительно контрольных значений. Содержание меди, ассоциируемое с содержанием супероксиддисмутазы, в печени увеличивалось на вторые сутки постишемического периода в среднем в 2.5 раза, в гиппокампе достоверных изменений содержания меди не было обнаружено. Ключевые слова: оксид азота, ЭПР-спектроскопия, ишемия мозга, медь, печень, гиппокамп.
МРТ-управляемая терапия
Authors: Богачев Ю.В. , Никитина А.В. , Фролов В.В. , Чижик В.И.
Published: May 2020

Magnetic resonance (MR) theranostics is a new direction of modern medicine, in which high diagnostic capabilities of magnetic resonance methods are combined with therapeutic effects on various organs of physical fields of various nature. The features and clinical applications of MR-theranostics methods and equipment, including MRI-guided high-intensity focused ultrasound surgery (tumor ablation), MRI-guided radiation (x-ray) therapy, MRI-guided proton therapy, and MRI-guided radiofrequency therapy, are considered.
Биологические и реологические свойства коллагена, сшитого глутаровым альдегидом
Authors: Нащекина Ю.А. , Луконина О.А. , Дарвиш Д.М. , Нащекин А.В. , Елоховский В.Ю. , Юдин В.Е. , Михайлова Н.А.
Published: May 2020

The effect of the concentration of glutaraldehyde, which has the ability to crosslink collagen type I molecules, on its stability, mechanical strength, and cytotoxicity was studied. It is shown that under physiological conditions, collagen containing 10 and 18% glutaraldehyde possesses the greatest stability. The results of the rheological analysis showed that with a minimum concentration of glutaraldehyde (1%), the mechanical characteristics of collagen hydrogels are significantly improved. However, a concentration of glutaraldehyde above 10% reduces cell viability by 50%.
Artificial intelligence in modern medicine- evolving necessity of the present and role in transforming the future of medical care (Preprint)
Authors: Bhattad Pradnya Brijmohan , Jain Vinay
Published: May 2020

UNSTRUCTURED

The dexterity of computer systems to resemble and mimic human intelligence is artificial intelligence. Artificial intelligence has reformed the diagnostic and therapeutic precision and competence in various fields of medicine. Artificial intelligence appears to play a bright role in the medical diagnosis. Computer systems using artificial intelligence help in assessment of medical images and enormous data. This research aims to identify how the artificial intelligence-based technology is reforming the art of medicine. Artificial intelligence empowers providers in improving efficiency and overall healthcare. Newer machine learning techniques lead the automatic diagnostic systems. Areas of medicine such as medical imaging, automated clinical decision-making support have made significant advances with respect to artificial intelligence technology. With improved diagnosis and prognosis, artificial intelligence possesses the capability to revolutionize various fields of medicine. Artificial intelligence has its own limitations and cannot replace a bedside clinician. In the evolving modern medical digital world, physicians need to support artificial intelligence rather than fear it replacing trained physicians for improved healthcare.
Rubidium-82 Generator Yield and Efficiency for PET Perfusion Imaging: Comparison of Two Clinical Systems (Preprint)
Authors: Dekemp Robert
Published: May 2020

UNSTRUCTURED

Introduction. Strontium-82/Rubidium-82 (82Sr/82Rb) generators are used widely for positron emission tomography (PET) imaging of myocardial perfusion. In this study, the 82Rb isotope yield and production efficiency of two FDA-approved 82Sr/82Rb generators were compared.
Methods. N=515 sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL/min) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL/min). The generator yield (82Rb) and production efficiency (82Rb yield / 82Sr parent activity) were measured and compared after this conversion to a common scale.
Results. At the start of clinical use, the system reported 82Rb activity from daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, p<0.001) despite having similar 82Sr activity. Dose-calibrator ‘maximum’ (CardioGen-82®) values were found to under-estimate the integrated ‘total’ (RUBY-FILL®) activity by ~24% at 50 mL/min. When these data were used to convert the CardioGen-82 values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, p<0.001). The efficiency of 82Rb production improved for both systems over the respective periods of clinical use.
Conclusions. 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. When generator yield was expressed as the integrated total activity for both systems, the estimated 82Rb production efficiency of the CardioGen-82® system was ~7% lower than RUBY-FILL® over the full period of clinical use.
Value of SiPM PET in myocardial perfusion imaging using Rubidium-82 (Preprint)
Authors: Koenders SS
Published: May 2020

UNSTRUCTURED

Background: PET scanners using silicon photomultipliers with digital readout (SiPM PET) have an improved temporal and spatial resolution compared to PET scanners using conventional photomultiplier tubes (PMT PET). However, the effect on image quality and visibility of perfusion defects in myocardial perfusion imaging (MPI) is unknown. Our aim was to determine the value of a SiPM PET scanner in MPI.
Methods: We prospectively included 30 patients who underwent rest and regadenoson-induced stress Rubidium-82 (Rb-82) MPI on the D690 PMT PET (GE Healthcare) and within three weeks on the Vereos SiPM PET (Philips Healthcare). Two expert readers scored the image quality and assessed the existence of possible defects. In addition, interpreter’s confidence, myocardial blood flow (MBF) and myocardial flow reserve (MFR) values were compared.
Results: Image quality improved (p=0.03) using the Vereos as compared to the D690. Image quality of the Vereos and the D690 was graded fair in 20% and 10%, good in 60% and 50%, and excellent in 20% and 40%, respectively. Defect interpretation and interpreter’s confidence did not differ between the D690 and the Vereos (p>0.50). There were no significant differences in rest MBF (p≥0.29), stress MBF (p≥0.11) and MFR (p≥0.51).
Conclusion: SiPM PET provides an improved image quality in comparison to PMT PET. Defect interpretation, interpreter’s confidence and absolute blood flow measurements were comparable between both systems. SiPM PET is therefore a reliable technique for MPI using Rb-82.
How will Lockdown, social distancing and other respiratory and hygiene etiquettes implemented to mitigate COVID-19 affect incidence of other respiratory illnesses like PTB and Influenza? (Preprint)
Authors: Thapa Abishkar , Malla Monisma , Thapa Sunil
Published: May 2020

UNSTRUCTURED

Since the declaration of Covid-19 as a Pandemic by WHO on 13th March,2020 over 210 countries / territories have active cases and 1/3rd of the world’s population are on complete lockdown or partial restriction. Main route of transmission of Covid-19 is through droplets like most communicable respiratory illnesses followed by infected surfaces. Public measures like wearing masks, social distancing, hand washing and other respiratory hygiene are being followed in unprecedented level and people are tested rapidly if they show symptoms of the disease such as fever, cough, fatigue, myalgia and dyspnea.. These symptoms are similar to other respiratory diseases such as common flu, influenza, pneumonia and Tuberculosis and these preventive measures are also effective in these diseases. In Wuhan, China the lockdown lasted for 76 days and seems to follow similar course in other countries. The air pollution and travel has also decreased which will further decrease transmission of respiratory illnesses. These behavioral changes can get embedded into human cultures as seen in Japan after Spanish flu where people regularly wear masks in winter. This might play a vital role to decrease incidence of other respiratory illnesses like Tb and influenza for which we need to be observant and carry time series analysis of the pre and post pandemic data. With proper strategies this could be utilized as an opportunity to reduce burden of other respiratory communicable disease around the globe.
Observer repeatability and interscan reproducibility of 18F-sodium fluoride
coronary microcalcification activity (Preprint)
Authors: Slomka Piotr
Published: May 2020

UNSTRUCTURED

Background (words 199/200)
We aimed to establish the observer repeatability and interscan reproducibility of
coronary 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) uptake
using a novel semi-automated approach, coronary microcalcification activity (CMA).
Methods
Patients with multivessel coronary artery disease underwent repeated hybrid PET and
computed tomography angiography (CTA) imaging (PET/CTA). CMA was defined as
the integrated standardized uptake values (SUV) in the entire coronary tree exceeding 2
standard deviations above the background SUV. Coefficients of repeatability between
the same observer (intraobserver repeatability), between 2 observers (interobserver
repeatability) and coefficient of reproducibility between 2 scans (interscan
reproducibility), were determined at both vessel and patient level.
Results
In 19 patients, CMA was assessed twice in 43 coronary vessels on two PET/CT scans
performed 12±5 days apart. There was excellent intraclass correlation on a per-vessel
and per-patient level for intraobserver and interobserver repeatability as well as
interscan reproducibility (≥0.991 for all). There was 100% intraobserver, interobserver
and interscan agreement for the presence (CMA>0) or absence (CMA=0) of
coronary18F-NaF uptake. Mean CMA was 3.12±0.62 with coefficients of repeatability of
≤10% for all measures: intraobserver 0.24 and 0.22, interobserver 0.30 and 0.29 and
interscan 0.33 and 0.32 at a per-vessel and per-patient level respectively.
Conclusions
CMA is a repeatable and reproducible global measure of coronary atherosclerotic
activity.
BioDay Registry: Prospective, observational data collection regarding the use of new systemic treatment options in patients with atopic diseases in daily practice (Preprint)
Authors: BioDay Registry Jorien , Ariens Lieneke , Spekhorst Lotte , Kummeling Ischa , Thijs Judith , Bakker Daphne , de Ridder Ilona , Sloeserwij Annemieke , de Graaf Marlies , Romeijn Margreet , Voorberg Angelique , Kamsteeg Marijke , Schuttelaar Marie-Louise , de Bruin-Weller Marjolein
Published: May 2020

BACKGROUND

Dupilumab is the first antibody based treatment for atopic dermatitis (AD). It is expected that many new treatment options become available for the treatment of atopic diseases in the near future. Despite the high quality of clinical trials, results are not always generalizable to daily practice.

OBJECTIVE

Registry based collection of real life data can add information that is not gained in clinical trials.

METHODS

The BioDay Registry prospectively collects real life treatment results regarding effectiveness and safety of patients treated with new systemic treatment options for AD in a multicenter setting. Effectiveness is assessed based on both physician measured clinical eczema scores as well as patient-reported outcome measures. Long-term safety risks are monitored. The possibility for dose reduction in patients with disease control can be investigated. The treatment effect on other atopic co-morbidities will be monitored. The BioDay Registry can be easily adjusted, and new modules on new treatment options can be added. As outcome measures are in line with the core outcomes for eczema recommended by the global Harmonising Outcome Measures for Eczema (HOME) initiative, it is possible to merge data with other registries in future.

RESULTS

The BioDay Registry was considered as non-interventional by the local Medical Ethics Committee and the collection of data is performed according to the Helsinki Declaration. Protocol amendments will always be submitted for review to the Medical Ethics Committee.

CONCLUSIONS

The BioDay Registry will provide unique prospectively collected data on the use of targeted therapies in daily practice for AD patients. The results of this registry will contribute to the development of more personalized treatment strategies for patients with moderate to severe AD.

CLINICALTRIAL

ClinicalTrials.gov identifier: NCT03549416, retrospectively registered June 8, 2018.
Assessment and Prediction of Privacy Concerns on Health Apps (Preprint)
Authors: AlTamime Reham , Marmion Vincent , Hall Wendy
Published: May 2020

BACKGROUND

Mobile apps and IoT-enabled smartphones technologies facilitate collecting, sharing, and inferring from a vast amount of data about individuals’ location, health conditions, mobility status, and other factors. The use of such technology highlights the importance of understanding individuals’ privacy concerns to design applications that integrate their privacy expectations and requirements.

OBJECTIVE

This paper explores, assesses, and predicts individuals’ privacy concerns in relation to collecting and disclosing data on mobile health apps.

METHODS

We designed a questionnaire to identify participants’ privacy concerns pertaining to a set of 432 mobile apps’ data collection and sharing scenarios. Participants were presented with 27 scenarios that varied across three categorical factors: (1) type of data collected (e.g. health, demographic, behavioral, and location); (2) data sharing (e.g., whether it is shared, and for what purpose); and, (3) retention rate (e.g., forever, until the purpose is satisfied, unspecified, week, or year).

RESULTS

Our findings show that type of data, data sharing, and retention rate are all factors that affect individuals’ privacy concerns. However, specific factors such as collecting and disclosing health data to a third-party tracker play a larger role than other factors in triggering privacy concerns.

CONCLUSIONS

Our findings suggest that it is possible to predict privacy concerns based on these three factors. We propose design approaches that can improve users’ awareness and control of their data on mobile applications
Community-Care Approach for Social Work Practice: Learning from Community-Based Healthcare for Elderly in Yogyakarta
Authors: Soenarto Putri Tri Winarni , Abdallah Kafaa Kafa , Komara Yuda Tauchid
Published: May 2020

This article aims to demonstrate the application of a community-care approach in the provisioning of elderly social and health care services (hereafter, social-health care) through a case study at Elderly Family Development (Bina Keluarga Lansia–BKL) Mugi Waras in Sumbersari Village, Sleman Regency, Special Region of Yogyakarta Province. This institution was chosen as a case study since it represents the best community-based long-term social-health care institution for the elderly in Indonesia. Based on the findings that have been analyzed, it was concluded that there has been shifting of institutional care provision in the community care regime towards more inclusion with mixed welfare features. This may have occurred because BKL was suffering from the lack of resources they have in dealing with the increased needs of the elderly and increased risk. Consequently, even though the influence of external stakeholders in this initiative appears quite strong, such a community-centered care initiative can be continually maintained and resulted in the hybridization model of a care regime. For social worker’s practitioner insight, the paradigm of program implementation in the BKL Mugi Waras can be adopted as a community-based social work practice that appears to fit developing countries, where elderly service intervention should be fine-tuned to the elderly residents’ living arrangements.
COST-EFFECTIVE ANALYSIS IN TREATING DIABETES MELLITUS WITH COMORBIDITY
Authors: JAFARNIA MINA , DR DEEPIKA , RAVESHI FARZANEH , KIRUBAKARN J JOHN
Published: May 2020

Objective: The main objective of this study is to sort out the most common prescription patterns and their cost-effective analysis (CEA).

Methods: A prospective study design is followed to collect the data. Based on the percentage, the first three comorbidities which occupy a major part of the sample are taken into consideration. The top two used prescriptions for each comorbidity are selected and CEA is performed for those.

Results: Diabetes mellitus (DM) with hypertension (HTN) comprise the majority of the sample (37%). Two majorly used prescription patterns are sorted out and CEA is performed which revealed that prescription pattern A is more cost effective than prescription pattern B. Second major part of the sample is occupied by only cases with DM (21%) which is excluded as it does not have any commodities. After only DM, DM + infections occupy a major part (8%). Two majorly used prescription patterns are sorted out and CEA is performed which revealed that prescription pattern A is more therapeutically effective than prescription pattern B but not cost effective. The 3rd major comorbidity is DM + CVA (8%). In this case, the results demonstrated that prescription pattern A is more cost effective than prescription pattern B.

Conclusion: The major commodities of DM are HTN, infections, and coronary artery disease. The cost-effectiveness evaluation revealed that physicians are only considering the therapeutic efficacy as a major concern but not the economic burden. This study concludes the importance of considering the financial burden with relationship to their respective therapeutic efficacy provided by an individual prescription.
THE IMPACT OF MEETING ACCREDITATION STANDARDS ON THE QUALITY OF THE ELECTRONIC HEALTH RECORDS
Authors: HOSSAM ATTIA MOHAMED , IBRAHIM ABDELNASSER
Published: May 2020

Objective: Electronic health records (EHRs) are considered a way to make the management of patient information easier, improve efficiency, and decrease costs related to medical information management. Compliance with requirements from accreditation bodies on quality of documentation ensures the complete and accurate patient information in the EHR. The purpose of this study is to measure the effect of quality accreditation on the quality of documentation in the EHR.

Methods: A simple random sample of 18% of patient records was manually selected each month during the entire study period from the population of discharged patients. The auditing process included 18 months starting from January 2014 until June 2015. The data collection was performed by a quality management unit using a modified medical record completeness checklist adapted from Joint Commission International (JCI) criteria.

Results: The results of the study show the improvement in compliance with complete medical records’ documentation after the JCI accreditation. However, after the accreditation, the compliance suffers a dramatic fall which could be referred to the post-accreditation slump. The compliance then improved again to reach higher levels of compliance. Using paired t-test, the mean of total compliance with complete and accurate medical records in October 2014 was less than in May 2015.

Conclusion: This study highlighted the performance of one process before and after the first accreditation of the organization showing the real difference between the performance before and after the accreditation and explaining the drop that happened just after the accreditation.
ANALYSIS OF CO-OCCURRENCE OF AUTISM SPECTRUM DISORDER WITH OTHER NEUROLOGICAL DISORDERS
Authors: CHANDRAKALA ELUMALAI , NAGARAJ KAKANAHALLI
Published: May 2020

Objective: The present study explores the co-occurrence of autism spectrum disorder (ASD) with associated disorders such as epilepsy, attention deficit hyperactive disorder (ADHD), Down’s syndrome (DS), and cerebral palsy (CP).

Methods: This cross-sectional study was carried out in special schools of four districts in Karnataka. A total of 49 ASD individuals were identified among 552 developmentally challenged children. ASD individuals were screened for associated neurological disorders and segregated the data as ASD, ASD with epilepsy, ASD-epilepsy-ADHD, ASD with DS, and ASD with CP. The karyotype analysis was carried out for chromosomal anomalies.

Results: It is found that 57% of the individuals showed only ASD features and the remaining 43% shared ASD features with other neurological disorders. Among 43% of comorbidity, 35% of ASD individuals have epilepsy, 2% have epilepsy-ADHD, 4% have DS, and 2% have CP.

Conclusion: This study supports the strong association between ASD with epilepsy, DS, ADHD, and CP. However, the extent of association of ASD with epilepsy is higher than other neurological disorders. As both are complex neurological disorders, they both show intellectual disability and involve multiple genetic factors. The present investigation is the unique and first report of this study region and also supports earlier studies, suggesting that there is an association of ASD with other neurological disorders.
EVALUATION OF THE ANTICANCER PROPERTIES OF TURMESAC® IN HUMAN CERVICAL ADENOCARCINOMA
Authors: HM FIROZ , S NANJUNDAIAH , CT SADASHIVA
Published: May 2020

Objective: In the current study, an extract of turmeric rhizome (Turmesac®) was evaluated for possible anticancer activity in human cervical adenocarcinoma (HeLa) cells.

Methods: Turmesac®’s ability to elicit cytotoxicity in cancer cells was evaluated by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay (MTT) assay, where the IC50 value was determined. Apoptosis induction and cell cycle arrest were analyzed by flow cytometry post-Turmesac® IC50 value treatment for 24 h.

Results: The determined IC50 value of Turmesac® in HeLa cells was 115.12 μg/ml. This concentration was able to induce apoptosis 2 times greater than the apoptotic standard, camptothecin, treated cells. Cell cycle arrest was observed at the G0/G1 and S phases in Turmesac® treated HeLa cells.

Conclusion: Turmesac® shows the potential of being a promising anticancer agent that may be incorporated into chemotherapies, but further study is required to elucidate the exact mechanisms involved with longer treatment duration, as would be the case in clinical trial phases.
COMPARISON OF PERFORMANCE OF TWO WIDAL TEST TECHNIQUES WITH STOOL CULTURE IN THE DIAGNOSIS OF TYPHOID FEVER AT THE DSCHANG DISTRICT HOSPITAL, WEST CAMEROON
Authors: NATHEU CERGE KAMHOUA , PHÉLIX TELEFO BRUNO
Published: May 2020

Objective: This study is aimed to compare the performance of two Widal test techniques with stool culture in the diagnosis of typhoid fever.

Methods: A cross-sectional study was performed at the Dschang District Hospital in patients clinically suspected to have typhoid fever, whose stool was collected for stool culture. Furthermore, venous blood was collected and the serum was tested by both Widal slide agglutination test and Widal tube titration test.

Results: The results showed that out of 750 participants include in the study, 325 (43.33%) were positive for Widal slide agglutination test, 174 (23.20%) for Widal tube titration test, and 159 (21.20%) for stool culture. The sensitivity, specificity, positive predictive value, and negative predictive value of Widal slide agglutination test with respect to stool culture were 97.48%, 71.23%, 47.69%, and 99.22%, respectively, but 100%, 97.46%, 91.37%, and 100% for the Widal tube titration test. With the stool culture, Widal slide agglutination test had a moderate agreement (kappa = 0.47), but Widal tube titration test had an absolute agreement (kappa = 0.94).

Conclusion: Widal tube titration test should be used in place of Widal slide agglutination test in the diagnosis of typhoid fever in the case of limited access to stool culture test.
IMPACT OF PATIENT COUNSELING ON HEALTH KNOWLEDGE AND MEDICATION ADHERENCE IN ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS
Authors: P UNNATI , S ANUSHREYA , KEERTHANA G GABRIELA , P MOUNICA
Published: May 2020

Objective: This study evaluated the impact of clinical pharmacist-led intervention in health knowledge and medication adherence of Asthma and chronic obstructive pulmonary disease (COPD) patients.

Methods: Questionnaires were designed to assess Health knowledge for Asthma and COPD separately. Medication adherence was measured by using the Morisky Medication Adherence Scale-8. Pre-counseling patient responses were recorded. Patient counseling was given regarding the disease condition, medications, and medication use at baseline visit. Patient responses were re-measured upon follow-up visit. The data extracted were tabulated, statistically analyzed and the results were obtained.

Results: A total of 141 patients completed the study. Before counseling, the mean (±standard deviation) of knowledge and adherence levels were found to be 8.51±3.36 and 5.01±2.11, respectively. After counseling, they increased up to 12.72±2.16 for knowledge (p<0.0001) and 6.60±1.35 (p<0.0001) for medication adherence. The majority of subjects had about 11–30% increase in knowledge as well as medication adherence. Male patients were more adherent to their medication regime than females.

Conclusion: The study demonstrates the positive impact of education and counseling provided by a clinical pharmacist in achieving better therapeutic outcomes – through improvement in medication adherence and health knowledge. In conclusion, continuous education programs and patient counseling should be conducted for chronic diseases to reiterate the importance of medication adherence and, in turn, prevent recurrences, arrest disease progression, minimize hospitalization, and ultimately improve quality of life.
Adaptação transcultural do The Teacher Efficacy for Inclusive Practices (TEIP): versão brasileira
Authors: Furtado Nina Karla Cristina , Souza da Costa Silva Simone , Ramos Pontes Fernando Augusto
Published: May 2020

Este estudo objetivou realizar a adaptação transcultural do The Teacher's Efficacy for Inclusive Practices (TEIP) para o contexto brasileiro. O TEIP é um instrumento composto por 18 perguntas categorizadas em três dimensões, sendo elas: estratégias de ensino inclusiva, eficácia no controle de comportamento e eficácia na colaboração. É utilizado para medir a autoeficácia do professor para ensinar em salas de aula inclusivas. Foram realizadas cinco etapas metodológicas: tradução, síntese das traduções, tradução reversa, análise de comitê e teste piloto. O público-alvo do estudo piloto foi constituído por 15 professores de Educação Básica da mesorregião do estado do Pará- Brasil. Após todas as avaliações, a escala mostrou-se de fácil aplicação, bons níveis de aceitação e compreensão. O TEIP versão brasileira está adaptado no que se refere às equivalências semânticas, idiomáticas, conceituais e culturais.
Costosas banalidades de la humanidad. Experimentación publicitaria mediada por la realidad aumentada para promover el criterio medioambiental: Publicidad aumentada
Authors: Puentes Castañeda Víctor Hugo , Bohórquez Ricardo Andrés
Published: May 2020

La investigación abordada en el presente artículo tuvo como objetivo analizar las percepciones emotivas de un grupo focal de jóvenes estudiantes de la Fundación Universitaria los Libertadores con edades comprendidas entre 17 y 23 años de edad, mediante la realización de un ejercicio publicitario que permitió observar los niveles de recordación generados a partir de la exposición a dos avisos en diferentes intervalos de tiempo: uno de corte tradicional bidimensional; y el mismo aviso traducido a la tecnología emergente de realidad aumentada. La metodología implementada en la investigación fue de tipo exploratorio: implicó el desarrollo de 3 herramientas de tipo matriz de análisis y lectura. La primera de ellas se compuso para llevar a cabo el proceso de traducción de la pieza bidimensional a la narrativa enriquecida con realidad aumentada, comprendiéndose en su elaboración qué elementos constitutivos del mensaje sobresalían en importancia sobre otros que no eran indispensables. La segunda, a su turno, se empleó para registrar las percepciones emotivas de los participantes en el experimento, comparándolas entre los dos tipos de piezas en dos momentos diferentes; y con la tercera se pretendió analizar los niveles de apego hacia las dos piezas expuestas. Estas dos herramientas tuvieron como finalidad registrar el nivel de recordación en el tiempo generado por los spots que se presentaron. Se concluye que la realidad aumentada genera impacto en los espectadores y aumenta la capacidad de recordación, mas no en los niveles esperados. Por otra parte, se encuentra que fue posible incorporar los conceptos del diseño positivo para la traducción y análisis de piezas publicitarias, que además funcionan como medio metodológico para evaluar y registrar los estados de recordación. Esto facilitó el proceso de diseño y desarrollo de un aplicativo para dispositivos móviles, como una propuesta de publicidad de realidad aumentada extendida — publicidad aumentada—
Videoactivism and Construction of Mediatic Identities, Youtube and #YoSoy132
Authors: Sola-Morales Salomé
Published: May 2020

The main goal of this paper is to analyze #YoSoy132 construction of mediatic iden-tities through videoactivism, and to question if YouTube was determinant or simply instrumental in the implosion of the movement. During the 2012 “Mexican Spring”, stu-dents and citizens not only occupied the streets to quest for a “real democracy” or to express their dissent through very significant demonstrations, but they also occupied the internet to protest. First of all, identity features of the movement are analyzed in relation with the following variables: 1) nucleus of belonging, 2) main sociodemographic features, 3) forms of leadership, 4) interests, 5) collective identity, and 6) relationship with otherness. Second, through a qualitative methodology —content analysis—, this paper analyzes the most relevant pieces of videoactivism produced by young adults. This study focused on the role and function of the videos to know if social media was “instrumental” or “determinant”. Third, mediatic identities represented in the videos are analyzed by exploring the following aspects: a) protagonists appearing in the vid-eos: main role, gender and age range, b) locations where these characters appear and c) type of identity represented: hegemonic or counter-hegemonic, majority or minority. The main result of this research is that a resistence and contra-hegemonic identity is created through YouTube videos by young Mexicans. Moreover, being #YoSoy132 goes far beyond being young, student or belonging to a specific university. In this regard, the scenario is not occupied by a single subject or specific group of people, but it belongs to the “oppressed” and to persons at risk or discrimination.