bluuebunny/crossref_metadata_2025 huggingface dataset:
Patterns of Patient Recruitment in Clinical Studies on the Example of International Multicenter Clinical Studies (IMCTs)
Authors: Milovanov S. S.
Published: September 2023

Introduction. Patient recruitment is one of the main quantitative and qualitative characteristics of a clinical trial. As a quantitative characteristic, the recruitment of patients is, first of all, the final figure necessary to answer the researcher's question; as a qualitative characteristic, the recruitment of patients is a process subject to influence. The recruitment of patients in the center is determined by the rate per month and allows you to gain the statistical power of the protocol, and if the recruitment of patients does not reach the planned capacity, then the capacity may not be gained and this leads to the failure of the clinical trial. Failures in patient recruitment reported in the literature lead to more than 80 % of failed clinical trials of all phases. Patient recruitment as a process is influenced by various factors, and the authors identify recruitment predictors, recruitment facilitators, and barriers to patient recruitment.

Aim. To consider the general features and patterns of recruitment of patients in clinical trials on the example of international multicenter clinical trials.

Materials and methods. We analyzed the quantitative characteristics of patient recruitment in 4 clinical trials with successful recruitment.

Results and discussion. Despite the uniqueness of each protocol, the set of patients has its own patterns common to all clinical studies. It was studied, in particular, that the integrative assessment of the preliminary recruitment of patients by the researcher of the clinical center is not associated with an objective pool of patients and affects the rate of patient recruitment and targeted patient recruitment. We found that the number of clinical centers not recruiting patients in each study is at least 30 % of all centers involved. Three patient recruitment rates have also been identified that need to be considered when planning a clinical trial.

Conclusion. We have identified patterns in patient recruitment that will help in planning clinical trials.
Improvement of Myocardial Structure after Developed Fibrous Degeneration Under the Use of Allogenic Biomaterial
Authors: Lebedeva A. I. , Afanasiev S. A. , Gareev E. M. , Kondratieva D. S. , Musina L. A. , Popov S. V. , Prusakov A. V. , Yashin A. V. , Ponamarev V. S. , Radnatarov V. D.
Published: September 2023

Introduction. The question of the possibility of recovery of postischemic myocardium remains relevant.

Aim. The aim of the study was to study the effect of dispersed decellularized allogeneic extracellular matrix (allogeneic biomaterial, DAB) on the developed fibrous degeneration of the myocardium, as well as to reveal the possible mechanisms of cellular regeneration.

Materials and methods. The muscular wall of the heart of rats was subjected to cryodestruction. After 45 days, the rats of the main group were intramyocardially injected with a suspension of allogeneic biomaterialinto the area of the affected myocardium, and the rats of the control group were injected with saline.

Results and discussions. In the experimental group, there was a regression of the formed fibrous connective tissue, chemoattraction of progenitor cells, their differentiation and integration into the myocardium. The thickness of the muscular part of the wall of the left ventricle was three orders of magnitude higher than in the control group.

Conclusion. Analysis of the results of the study indicates that the heart in adult mammals has a powerful regenerative reserve. It is likely that, based on the use of DAB, a protocol can be developed that allows the restoration of the heart muscle even in conditions of already developed fibrous degeneration.
Development of Injectable Formulation of 4’-O-benzyloxycarbonyl-etoposide Derivative Based on Human Serum Albumin for the Chemotherapy of Breast Cancer
Authors: Kovshova T. S. , Boiko S. A. , Merkulova M. A. , Osipova N. S. , Moiseeva N. I. , Malinovskaya Ju. A. , Mantrov S. N. , Gelperina S. E.
Published: September 2023

Introduction. One of the promising strategies for the development of injectable formulations of poorly water-soluble drugs is the preparation of their nanosuspensions stabilized with albumin. A well-known example of the successful implementation of this technology is Abraxane® (nanoparticle albumin-bound paclitaxel). In the present study, this approach is used for the development of the injectable formulation of a hydrophobic etoposide prodrug.

Aim. Development of the injectable formulation of a novel 4'-О-benzyloxycarbonyl derivative of etoposide (ETP-cbz) based on human serum albumin and evaluation of its cytotoxicity against breast carcinoma cells (BC).

Materials and methods. The structure of ETP-cbz was confirmed by NMR spectroscopy and elemental analysis; log P was calculated in silico using Molinspiration Cheminformatics. The ETP-cbz-HSA nanoparticles were prepared by high pressure homogenization. The particle size, size distribution, and disintegration concentration were evaluated by dynamic light scattering (DLS) and atomic force microscopy (AFM). The contents of ETP-cbz and albumin in the formulation were determined by HPLC. The conversion ETP-cbz-HSA to etoposide was studied in a model medium in the presence of esterase. The cytotoxicity of ETP-cbz-HSA compared to etoposide and free ETP-cbz was assessed on BC cells (HBL-100 and MCF-7) using a colorimetric MTT assay.

Results and discussion. ETP-cbz exhibited higher hydrophobicity as compared to the etoposide (log P 2.42 vs 0.7, respectively). Due to easy cleavage of the carbonate bond in the presence of esterase, ETP-cbz can be considered an etoposide prodrug. The ETP-cbz-containing HSA nanoparticles prepared by a high-pressure homogenization technique had the particle size of 110 ± 9 nm (DLS) and a low disintegration concentration of 3.0 ± 0.1 μg/mL. The drug content was 1.75 mg/mL. The nanoformulation demonstrated high cytotoxic activity in vitro against MCF-7 and HBL-100 cells that was comparable to the activity of substances etoposide and ETP-cbz.

Conclusion. The obtained nanoformulation of etoposide prodrug based on albumin, suitable for injection, showed high cytotoxicity against breast cancer cells in vitro and deserves further study to assess the possibility of its use in breast cancer chemotherapy.
Analisis kemampuan numerasi matematis siswa dalam menyelesaikan masalah TIMSS ditinjau dari gender
Authors: Alfarisi Alfarisi , Suryaningrum Christine Wulandari , Firdaus Hana Puspita Eka
Published: September 2023

Kemampuan numerasi adalah keterampilan dalam menggunakan, memahami, serta menganalisis matematika untuk mengerjakan masalah dalam kehidupan sehari-hari. Penelitian memiliki tujuan mencari tahu perbedaan kemampuan numerasi matematika siswa dalam mengerjakan masalah TIMSS (Tren in InternasionalÂ  Mathematics and Science Study) dilihat dari gender yaitu pengkatagorian berdasarkan jenis kelamin. Metode penelitian ini menggunakan penelitian kualitatif deskriptif. Berdasarkan studi pendahuluan dari 28 siswa hanya terdapat 4 siswa yang mampuÂ  mengerjakan masalah TIMSS. Oleh karena itu, subjek yang terpilih sebanyak 4 siswa kelas VIII E salah satu SMP Â di kabupaten Jember provinsi Jawa Timur dengan 2 siswa laki-laki serta 2 siswa perempuan. Instrumen menggunakan 2 soal masalah TIMSS terkait pemecahan masalah di kehidupan sehari-hari, wawancara, serta dokumentasi. Selain itu, analisis data menggunakan pertama reduksi data, kedua penyajian data, serta terakhir penarikan kesimpulan, dilanjutkan pengujian kesahihan data menggunakan triangulasi sumber. Peneliti memilih subjek berlandaskan indikator kemampuan numerasi dari 4 siswa sebagai subjek penelitian tersebut menunjukkan kemampuan numerasi siswa laki-laki lebih unggul daripada siswa perempuan. Perbedaan kemampuan numerasi siswa dilihat berdasarkan 3 komponen indikator kemampuan numerasi. Perbedaan dikarenakan kemampuan penalaran siswa laki-laki lebih baik dibandingkan siswa perempuan dalam mengerjakan masalah di kehidupan nyata. Siswa laki-laki juga lebih unggul dalam pemahaman konsep mengerjakan masalah matematika.Â Kata kunci: Kemampuan Numerasi ; Masalah TIMSS ; Gender
THE EFFECTIVENESS OF COMIC STRIPS ON THE STUDENTS IDIOMATIC EXPRESSION MASTERY
Authors: Nadiya Siti , Rahmat Hery , Muhammad Muhammad
Published: September 2023

This study aimed to find out whether comic strips improve the studentsâ€™ mastery on idiomatic expressions. The research used a pre-experimental type with one-group pre-test and post-test design. The population was the second-grade students of the Senior Islamic Boarding School in Lombok. The researcher chose one class which consisted 16 students as the sample. The data was analyzed by using t-test. The data analysis revealed that the use of comic strips on students' idiomatic expression mastery was successful. The increase in the pre-test to post-test score of studentsâ€™ average scores is an indication that the students have really understood and done well in all the questions assigned to them. The treatment given using comic strip media is very helpful for students in answering the questions given. Comic strips help students in overcoming errors in interpreting the idiom. The research analysis of studentsâ€™ scores on the pre-test and post-test scores, it shows that the value of the t-test result is 0.000 0.05, therefore it can be concluded that the alternative hypothesis (Ha) is accepted and the null hypothesis (Ho) is rejected.
STUDENTS’ COMPREHENSION IN ENGLISH MEDICAL TERMINOLOGY AT KHAIRUN UNIVERSITY
Authors: Harun Mutia , Latif Taib , Aboe Roswita M. , Sari Fitria Wulan
Published: September 2023

This study aims to determine the understanding of medical students about English medical terminology. This study used descriptive quanitative method. There were 21 medical students at Khairun Ternate University who were involved in this research. By using purposive sampling technique. . Data was collected by using a test and questioner via google form. Of the 21 students, only 4 students got good grades, the other 17 were very low. The results of this study indicate the average value of students is 49.7 in the poor category.
From sperm selection to embryo development: New insights into key assisted reproductive technologies in the horse.
Authors:   , Umair Muhammad
Published: September 2023

Since the early 1990s, sport horse breeding has increasingly adopted assisted reproductive technologies (ARTs), starting with artificial insemination (AI) and followed by embryo transfer and in vitro embryo production (IVP). AI is preferentially performed with chilled transported semen, which is limited by optimal storage times of 24-48 hours. We investigated the impact of prolonged cold storage (96 hours at 5 °C) on sperm quality and found time-related increases in plasma membrane fluidity and intra-cellular Ca2+, indicators of premature capacitation, that probably explain diminishing fertility. While IVP by intracytoplasmic sperm injection (ICSI) dramatically reduces the number of ‘fertile’ spermatozoa required, it bypasses natural sperm selection processes that prevent sperm with damaged DNA fertilizing the oocyte. We developed a 3-layer density-gradient centrifugation technique that selects a population of motile, morphologically normal spermatozoa with intact DNA better suited for ICSI. We also investigated the impact of IVP on early cell lineage segregation and found IVP blastocysts to contain fewer, more widely dispersed epiblast cells. Epiblast cell dispersal may explain why IVP embryos are less viable than in vivo embryos, but more likely to give rise to monozygotic twins. Fortunately, transferring IVP blastocysts into a mare's uterus triggered rapid epiblast compaction. Whereas IVP embryos are routinely cryopreserved, freezing larger (>300 µm diameter) in vivo-derived blastocysts has proven challenging. Recently, it transpired that puncturing large blastocysts and aspirating the blastocoel fluid improves their freezability; we further demonstrated that punctured embryos survive vitrification better than slow-freezing. Overall, this thesis highlights areas for improvement within equine ART.
Green Economy Based On Sharia Maqashid Case Study In Sinyior Village, Sinyior District, South Tapanuli District
Authors: Harahap Nasruddin Khalil , Siregar Sawaluddin , Hardana Ali
Published: September 2023

The purpose of this research is to briefly examine the meaning of Green Economy and Maqashid Syariah, with the aim that the knowledge index of the people of Sorkam Tengah Village will be better. This study explains these two concepts, the essence of which is how to keep nature in balance. Towards a greener economy is a sustainable goal for every country, including Indonesia. The application of the Green Economy application can reflect the quality of the environment in Indonesia today. Economic, social and environmental like an unbroken cycle of architecture. Environmental quality is highly dependent on economic and social outputs. Maqashid Syariah is a new trend in the study of Ushul Fikh which has developed in the contemporary era. The development of Islamic law in the contemporary era is felt to be more promising when using the methods contained in Maqashid Syariah. As a developmental discipline from ushul fiqh, Maqashid Sharia is now much loved by Islamic law experts for deeper study. Therefore, adequate information is needed about the literature review that discusses Maqashid Syariah from classical to contemporary times. The type of research used to complete the author's journal is of a qualitative type considering that the form of data presentation is descriptive descriptions, with data sources obtained from the general public. direct and indirect (primary and secondary).
ISLAMIC EDUCATION FOR ADOLESCENTS IN THE ERA OF DISRUPTION IN OVERCOMING THE MORAL CRISIS
Authors: Lundeto Adri
Published: September 2023

Technological developments have led to the abandonment of conventional methods towards new methods that are considered easier. This then causes disruption, where there is a change in moral development, especially in adolescents in an increasingly negative direction. This research will be carried out to look at how Islamic Education can overcome the moral crisis that occurs among adolescents in the era of disruption. This research will be carried out using a descriptive qualitative approach. The data used in this study came from the results of previous research or studies. The results of this study then found that the approach to teaching must also change according to current developments. In this case, there are at least three aspects that can develop, namely learning media, learning materials, and teaching staff. Media and learning materials can use technology such as media-based and online learning, while educators need to improve their quality regarding their understanding of technology.
INDONESIAN NATIONAL TEAM CRICKET ATHLETES ANXIETY AHEAD OF CAMBODIA’S 2023 SEA GAMES MATCHES
Authors: Basri Hasan , Nurhidayah Siti , Ridlo Azi Faiz , Aridan Tangkudung Albert Wolter
Published: September 2023

This study aims to describe the level of anxiety of the Indonesian National Team cricket athletes ahead of the 2023 Cambodian Sea Games and how to control anxiety in the athletes' environment. This study used quantitative research through SPSS Version 24. The sample in this study were 16 Indonesian National Team cricket athletes. The instrument used to obtain data uses a closed questionnaire. The questionnaire distributed was the SCAT (Sport Competitive Anxiety Test) totaling 15 questions. As for data analysis using descriptive statistics which has the aim of describing the data, so that researchers have an overview of the data to be used in research. The results showed that overall the Indonesian National Team cricket athletes experienced an average level of anxiety. This is because the athletes have technical skills in competition and the athlete's mind so that it affects the satisfaction that is subjectively felt in him. The emergence of pressure from outside in the form of demands and expectations so as to make the athletes doubt. So that this factor affects the emotional intelligence of Indonesian national team cricket athletes at an average level of anxiety. Meanwhile, controlling anxiety in athletes can be done by increasing the level of religiosity and collaborating between athletes, coaches, and teams to understand the source of anxiety.
Creative Writing Class Using Narrative Theory: Focusing on the Relationship between Story, Narrative, and Text
Authors:   The Korean Society of Culture and Convergence, Han Huisu
Published: September 2023

This thesis is a study on creative writing using narrative theory. Narrative theory studies the process by which a story is narrated and completed as a text. We perceive something(story), compose and transform it(narration) to create a new world(text). Each of these courses is creative. First, a story is an abstract construct of the world. Perceiving these abstract stories is the first step of creativity in Narratology. The writer selects, arranges, and describes the perceived story based on his visions. This is the second stage of creativity. Finally, the text is presented to the reader. Text is a synthetic creation made of para-text and inter-text. This is the third stage of creativity in Narratology. Designing a writing class according to this narrative process, the creative process that appears at each stage(story-narrative-text) can be applied to writing. This means that we can logically teach the process of creativity through this class.
Analyzing Teacher Identity of Korean Language Teachers in Korea
Authors:   The Korean Society of Culture and Convergence, Moon Youngha , Oh Ahrim
Published: September 2023

This study aims to identify the identity of Korean language teachers in Korea by categorizing the factors of teacher identity into motivation for continuing as a Korean language teacher, role recognition, teacher efficacy, professional growth of Korean language teachers. The study also examines differences in teacher identity based on individual variables. A survey showed that they had the same recognition of their role regardless of individual variables, and they exhibited a high level of teacher efficacy, interest, passion, and willingness to develop professionalism. However, satisfaction with their career choice and intention to continue teaching as a profession were relatively low, and satisfaction with salary and willingness to recommend the profession were even lower.
Enhancing Cultural and Linguistic Competence in Korean Education Topic: Korean Food
Authors:   The Korean Society of Culture and Convergence, Kim Ku-In , Yum Jung-Eun
Published: September 2023

The purpose of this study is to develop a class lesson plan that integrates Korean culture and language at universities outside of Korea. Under the theme of “Bibimbap”, it was designed by combining Brinton's “Into-Through-Beyond” model, a CBL method, ACTFL 5Cs' “communication,” “culture” elements, and CEFR's “cultural competence. This lesson plan was applied to actual classes which presented a practical example of how this method of teaching can be achieved. As a result of this study, it was found that language and cultural skills improved at the same time. Learners were also found to be interested in all areas that were taught in-class such as language, culture, and presentation activities, which seemed to have a great influence on learners' language and cultural competence. This study is meaningful in that it not only develops a practical teaching model, but it is also applicable to actual classes thus increasing the completeness of the research.
Analysis of Research Trends in Counseling Program for Domestic University Students Using Text Mining Methods
Authors:   The Korean Society of Culture and Convergence, Yang Soonmi , Kim Sungbong
Published: September 2023

This study aims to use text mining to understand trends in domestic college student counseling programs and analyze their characteristics. We reviewed 1,245 domestic academic articles on 'college students', 'counseling', and 'programs' in RISS until April 2023, analyzing 204 articles for KCI listing or higher. The analysis revealed that 108 articles in 9 journals had more than 5 studies each, while 69 journals published less than 5 articles, totaling 96 articles. This indicates diverse journal coverage but also a concentration in a few. Keyword analysis highlights focus on 'program', 'research', 'career', 'group', 'college student', 'effect', and 'result', indicating a research emphasis on the effectiveness of career and group counseling programs for university students. Topic modeling identified key relevant topics. These findings provide a foundation for reinvigorating research on college student counseling programs.
A Study of Localization in the Stage Art of the Chinese Reimagined Musical
Authors:   The Korean Society of Culture and Convergence, Fu Linzi , Han Kyunghoon
Published: September 2023

The purpose of this study is to select “Fan Letter” as a representative work of the localization process of Chinese musicals; to identify the localization situation and success factors of the work from three aspects of stage design, costume design, and lighting design by referring to articles, monographs, musical videos, stage design manuscripts, costume design manuscripts, and other materials related to Chinese localized musicals; to analyze the impact of the integration of localized aesthetics and stage art on the overall performance of the musical; and to draw implications for the stage art production of Chinese localized re-created musicals in the future. The analysis shows that the stage design of the Chinese version of the musical Fan Letter deconstructed and utilized Shanghai architectural elements, the costume design referenced Chinese history and used traditional colors and local materials, and the lighting design used colors that are easy for Chinese to understand to highlight the characters' inner emotions. This shows that the production is innovative in its combination with Chinese culture in the localized re-creation of stage art. The clever fusion of Chinese elements and musicals can be a great expressive tool in the localization of musicals.
A Study on the Liberal Arts Education System and Major Free Choice System of Domestic National and Public Universities
Authors:   The Korean Society of Culture and Convergence, Jeon Jonghee
Published: September 2023

The purpose of this study is to explore the current state of the liberal arts education system of national and public universities in Korea, as well as department of free major as a major free choice system. National and public universities are in a situation where they must reflect the trend of the times and the demand for education while pursuing the nature and academic identity of education. This study aims to examine the liberal arts curriculum and organizational system, and the system for autonomy in searching and selecting majors of national and public universities in Korea. For the study, the latest data were investigated based on the university catalogs and school website released by national and public universities in Korea from April to July 2023. As a result of the study, the operation status and cases of the liberal arts curriculum and major free choice system of domestic national and public universities were presented, and the commonalities and differences were confirmed. Through this study, it will be possible to identify trends in the liberal arts curriculum and major selection system of domestic national and public universities and to seek future educational development directions.
Multicultural aspects and Religious Development of Early Indian Mahāyana Buddhism
Authors:   The Korean Society of Culture and Convergence, Choi Kyung Ah
Published: September 2023

Indian Mahayana Buddhism has diverse theories regarding its origin, but it is believed that this soteriological religious movement primarily emerged during the Kushan Dynasty. The Kushans, a nomadic people of Central Asia who were skilled in trade, had multicultural characteristics of Greek and Iranian. They embraced Indian religion and culture, and supported Buddhism to legitimize their rule. The creation of Buddha statues in this era had a great influence on the spread of Buddhism beyond India. This era marked an ideological shift, focusing on external power not only sticking to individual performance for the acquisition of the ultimate state. Charity and faithfulness being emphasized, the use of wealth for spiritual purpose was justified. Although the emergence of Mahayana Buddhism is interpreted from the perspective of evolution and development in the history of Buddhism, it is contrary to early Buddhism based on the Shramana tradition of asceticism. Nevertheless these traits of Kushan Buddhism significantly shaped the identity of early Mahayana Buddhism.
A Study on and Suggestions for the Operation of the K-POP Academy at the Korean Cultural Center in Thailand
Authors:   The Korean Society of Culture and Convergence, Yun Yeongsam , Jun Jongwoo
Published: September 2023

This study aims to find out what effects the K-POP Academy operated by the Korean Cultural Center in Thailand has on K-POP consumption and the Korean nation branding in the Thai market and to make suggestions for the operation of the K-POP Academy. At the results, in Thailand, K-POP was mainly consumed by females in their teens. It was found that K-POP draws great popularity in Thailand because its unique musical characteristics correspond to the essential excitement of the Thai people. In addition, it was analyzed that Thai people's ‘multi-cultural acceptance’ is not significantly related to K-POP consumption. On the other hand, ‘experience’ served as a fundamental reason for Thais to participate in the K-POP Academy. Lastly, it was found that the K-POP Academy has an effect on Thais’ intention to visit Korea and purchase Korean products, thus effectively enhancing Korea's nation branding.
A Study on Viewing Motivation and Satisfaction of Reality show: Focusing on Dating Reality show
Authors:   The Korean Society of Culture and Convergence, Rim Hoon
Published: September 2023

This study analyzed the Viewing motivation and satisfaction of college students who show active media use behaviors for Dating reality show. Also, based on this, suggestions for revitalizing the production of Dating Reality show were suggested. First, as a result of the analysis of factors for viewing motivation, five factor structures were identified: 'entertainment motivation', 'companion motivation', 'social usefulness motivation', 'learning/information motivation', and 'indirect experience motivation'. Second, as a result of analyzing the effect of factors of Dating reality show viewing motivation on viewing satisfaction, 'entertainment motivation', 'companion motivation' and 'learning/information motivation' were found to be statistically significant, and 'entertainment motivation' was found to have the greatest influence.
The Reality and Task of Home Visiting Korean Language Tutoring for Female Marriage Immigrants
Authors:   The Korean Society of Culture and Convergence, Kim HyunSook
Published: September 2023

The purpose of the study is to explore the 'Home Visiting Korean Language Tutoring' program run by the Ministry of Gender Equality and Family in South Korea. Recognizing changes over time, it evaluates the service's suitability for female marriage immigrants. Conducted through a literature review and surveys with 121 immigrants, the study identifies a high demand and satisfaction for the visiting education service, given its help in settling into Korean society. Nevertheless, it highlights a need for policy and educational improvements. It recommends measures such as the hiring of more Home visiting Korean language education instructors, implementing a fee-based system, establishing control mechanisms, addressing instructors' welfare issues, and proposing long-term policy improvements. The program shows promise in aiding integration, particularly for immigrants with children.
A Study on the Sustainability of the Legal Cultural City Project: Focused on the ECoC of Lille, France and Liverpool, UK
Authors:   The Korean Society of Culture and Convergence, Baek jiyeon , Kim Sunyoung
Published: September 2023

If we look at cities that have established themselves as successful cultural cities, we can see efforts to secure sustainability. However, in the case of Legal Cultural Cities within South Korea, it is evaluated that the consideration of sustainability is generally insufficient. Therefore, this study aims to contribute to enhancing the sustainability of Legal Cultural Cities in Korea by examining the cases of Lille, France, and Liverpool, UK, which have been recognized as successful cultural cities. The research findings are as follows: First, an independent dedicated organization that integrates cultural tourism, international cooperation, and urban regeneration is needed to ensure consistency and smooth performance of the project's goals. Second, it is necessary to form partnerships with stakeholders in various fields for organic public-private cooperation between the public and private sectors. Third, tax benefits or legal support systems should be established to promote private companies' investment attraction.
Effects of Youth Counselor's Traumatic Experience on their Burnout: The Roles of Resilience and Supervisor Support
Authors:   The Korean Society of Culture and Convergence, Kim Okhwan , Shim Hokyu
Published: September 2023

The purpose of this study was to find intervention measures for youth counselors to reduce burnout by examining the effect of trauma experience on counselor burnout through resilience and supervisor support. For this end, we used the case shock scale, resilience scale, supervisor support scale, and counselor exhaustion scale for 533 youth counselors. We obtained the following research results. First, the higher the trauma experience of youth counselors, the higher their burnout was. Second, the higher the resilience and supervisor support, the lower their burnout was significantly. The results of this study are consistent with previous studies, and the more trauma experiences of youth counselors, the less efficiently they may play the role of youth counselors, and resilience and supervisor support may reduce the burnout of youth counselors due to trauma experience.
The Effects of Negative Emotional Temperament in Early Childhood on the Sense of Community of Late School-age Children: the Mediating Effects of Peer Attachment and Self-esteem
Authors:   The Korean Society of Culture and Convergence, Lee Sangmi
Published: September 2023

This study was conducted to investigate the structural relationship among peer attachment, self-esteem, and early childhood temperament that affect the sense of community of late school-aged children. Data were used that collected from 1,397 children of the 6th grade of elementary school in the 13th year of the Panel Study on Korean Children (2020) and temperament survey data of the 5th year (2012). The data were analyzed by a structural equation model using AMOS 26.0. Negative emotional temperament in early childhood had a significant negative effect on the sense of community. In addition, peer attachment and self-esteem not only had a significant positive effect on the sense of community, but were also significant mediating factors in the relationship between temperament and the sense of community. Therefore, it is necessary to be considered the long-term effects of negative emotional temperament in early childhood, and programs to enhance peer attachment and self-esteem of children for promoting a sense of community in late school-age children.
The Effect of Parenting Attitudes on Career Identity in Adolescents: The Mediating Effect of Self-identity
Authors:   The Korean Society of Culture and Convergence, Zhou He , Kim SungBong , LEE SEJA
Published: September 2023

The purpose of this study is to explore how adolescents' perceived parenting attitude affects career identity and to verify the mediating effect of self-identity in the relationship between parental parenting attitude and career identity. The research question is as follows. First, do parenting attitudes and self-identity directly affect career identity? Second, does self-identity play a mediating role in the relationship between parenting attitude and career identity? For this study, an online self-administered questionnaire was conducted targeting middle school students across the country. Data collection was conducted for about 10 days from October 19 to October 31, 2022, and 454 samples who faithfully participated in the survey were selected as subjects for this study. The results were analyzed using the SPSS 25.0 program. First, parenting attitudes had a positive effect on self-identity and career identity, and second, self-identity had a mediating effect in the relationship between parental parenting attitudes and career identity.
Study on Korean Language Teaching and Learning Based on Collaborative Learning: Focus on the Designing Korean Collaborative Class Through a Analysis of Student's Perception
Authors:   The Korean Society of Culture and Convergence, Son Hyejin
Published: September 2023

The purpose of this study is to present a basic framework for Korean class design based on collaborative learning. Through the analysis of previous studies, a basic framework was presented. And based on the basic framework, a Korean reading class were designed and conducted for learners. After the class, a perception of the participating learners were investigated. As a result, in order to facilitate collaborative learning, procedures and strategies that increase learners' understanding and participation in collaborative learning must be considered from the design stage. In addition, a device for the instructor to properly intervene is needed. As a result, in this study, a basic framework for Korean class design based on collaborative learning was revised to reflect these findings. And the further studies on verify the effectiveness of the basic framework need to be conducted.
A Study on the Appearance Based Pedometer App UI Application Marketing Design
Authors:   The Korean Society of Culture and Convergence, Kim Myoungmi , Yu Sunhha
Published: September 2023

It is called behavioral induction in the sense of inducing a movement or action. This behavior is referred to as affordances, that is, what the actor can do with the environment and relationships. In this way, affordances becomes a basic concept in UI design. If it works as expected without explaining how to use it, it can be said that the object has affordances. Through the study of application design factors, environmental and internal capability factors that affect strategy setting and execution, and strategies derived using the application app problem and external environment analysis were studied. It also studies the marketing strategies of pedometer app platforms that are increasing user satisfaction by providing various benefits such as events and point accumulation.
A Study on Creation of Social Value of Village Community Media: Focused on Pyeonghwa-dong Village Community Newspaper, Jeonju
Authors:   The Korean Society of Culture and Convergence, Kang Yun Hyung
Published: September 2023

This study looks into Pyeonghwa-dong Village Community Newspaper, a village community media that represents Jeonrabuk-do and is assessed as a sustainably growing model in order to analyze whether it practically creates social values in the city and what value it creates if it creates any value. It is independent, expandability and continuity that shall be paid attention onto with regards to Pyeonghwa-dong Village Newspaper, which began to be published first in 2010 and has been issued without any skip till 2023 so far since its first publication thanks to pay-free volunteer journalists’ volunteering. Furthermore, it does not only deal with various kinds of local issues through corporation with neighboring small communities but also operate ‘on-line Dure’ motivated from Dure, a traditional community activity, to enhance the communication with community people. Based on both quantitative and qualitative assessments, this study has verified that Pyeonghwa-dong Village Community Newspaper has been creating social values through its activities of 13years.
Effect on cell survival and cytoophidium assembly of the adRP-10-related IMPDH1 missense mutation Asp226Asn
Authors: Keppeke Gerson Dierley , Chang Chia-Chun , Zhang Ziheng , Liu Ji-Long
Published: September 2023

Introduction: Inosine monophosphate dehydrogenase 1 (IMPDH1) is a critical enzyme in the retina, essential for the correct functioning of photoreceptor cells. Mutations in IMPDH1 have been linked to autosomal dominant retinitis pigmentosa subtype 10 (adRP-10), a genetic eye disorder. Some of these mutations such as the Asp226Asn (D226N) lead to the assembly of large filamentous structures termed cytoophidia. D226N also gives IMPDH1 resistance to feedback inhibition by GDP/GTP. This study aims to emulate the adRP-10 condition with a long-term expression of IMPDH1-D226N in vitro and explore cytoophidium assembly and cell survival. We also assessed whether the introduction of an additional mutation (Y12C) to disrupt the cytoophidium has an attenuating effect on the toxicity caused by the D226N mutation.

Results: Expression of IMPDH1-D226N in HEp-2 cells resulted in cytoophidium assembly in ∼70% of the cells, but the presence of the Y12C mutation disrupted the filaments. Long-term cell survival was significantly affected by the presence of the D226N mutation, with a decrease of ∼40% in the cells expressing IMPDH1-D226N when compared to IMPDH1-WT; however, survival was significantly recovered in IMPDH1-Y12C/D226N, with only a ∼10% decrease when compared to IMPDH1-WT. On the other hand, the IMPDH1 expression level in the D226N-positive cells was <30% of that of the IMPDH1-WT-positive cells and only slightly higher in the Y12C/D226N, suggesting that although cell survival in Y12C/D226N was recovered, higher expression levels of the mutated IMPDH1 were not tolerated by the cells in the long term.

Conclusion: The IMPDH1-D226N effect on photoreceptor cell survival may be the result of a sum of problems: nucleotide unbalance plus a toxic long-life cytoophidium, supported by the observation that by introducing Y12C in IMPDH1 the cytoophidium was disrupted and cell survival significantly recovered, but not the sensibility to GDP/GTP regulation since higher expression levels of IMPDH1-D226N were not tolerated.
MYC—an emerging player in mitochondrial diseases
Authors: Purhonen Janne , Klefström Juha , Kallijärvi Jukka
Published: September 2023

The mitochondrion is a major hub of cellular metabolism and involved directly or indirectly in almost all biological processes of the cell. In mitochondrial diseases, compromised respiratory electron transfer and oxidative phosphorylation (OXPHOS) lead to compensatory rewiring of metabolism with resemblance to the Warburg-like metabolic state of cancer cells. The transcription factor MYC (or c-MYC) is a major regulator of metabolic rewiring in cancer, stimulating glycolysis, nucleotide biosynthesis, and glutamine utilization, which are known or predicted to be affected also in mitochondrial diseases. Albeit not widely acknowledged thus far, several cell and mouse models of mitochondrial disease show upregulation of MYC and/or its typical transcriptional signatures. Moreover, gene expression and metabolite-level changes associated with mitochondrial integrated stress response (mt-ISR) show remarkable overlap with those of MYC overexpression. In addition to being a metabolic regulator, MYC promotes cellular proliferation and modifies the cell cycle kinetics and, especially at high expression levels, promotes replication stress and genomic instability, and sensitizes cells to apoptosis. Because cell proliferation requires energy and doubling of the cellular biomass, replicating cells should be particularly sensitive to defective OXPHOS. On the other hand, OXPHOS-defective replicating cells are predicted to be especially vulnerable to high levels of MYC as it facilitates evasion of metabolic checkpoints and accelerates cell cycle progression. Indeed, a few recent studies demonstrate cell cycle defects and nuclear DNA damage in OXPHOS deficiency. Here, we give an overview of key mitochondria-dependent metabolic pathways known to be regulated by MYC, review the current literature on MYC expression in mitochondrial diseases, and speculate how its upregulation may be triggered by OXPHOS deficiency and what implications this has for the pathogenesis of these diseases.
JunB: a paradigm for Jun family in immune response and cancer
Authors: Ren Fu-jia , Cai Xiao-yu , Yao Yao , Fang Guo-ying
Published: September 2023

Jun B proto-oncogene (JunB) is a crucial member of dimeric activator protein-1 (AP-1) complex, which plays a significant role in various physiological processes, such as placental formation, cardiovascular development, myelopoiesis, angiogenesis, endochondral ossification and epidermis tissue homeostasis. Additionally, it has been reported that JunB has great regulatory functions in innate and adaptive immune responses by regulating the differentiation and cytokine secretion of immune cells including T cells, dendritic cells and macrophages, while also facilitating the effector of neutrophils and natural killer cells. Furthermore, a growing body of studies have shown that JunB is involved in tumorigenesis through regulating cell proliferation, differentiation, senescence and metastasis, particularly affecting the tumor microenvironment through transcriptional promotion or suppression of oncogenes in tumor cells or immune cells. This review summarizes the physiological function of JunB, its immune regulatory function, and its contribution to tumorigenesis, especially focusing on its regulatory mechanisms within tumor-associated immune processes.
The long-term safety and effectiveness of the loop technique in left ventricular lead dislocation
Authors: Dong Mengya , Liang Chenyuan , Cheng Gong
Published: September 2023

Objectives

Cardiac resynchronization therapy (CRT) is a well-established method that improves the clinical symptoms and long-term prognosis of specific heart failure (HF) patients by restoring systolic synchronicity and enhancing myocardial function. However, the high rate of intraoperative and postoperative left ventricular (LV) lead dislocation limits its application to a great extent. The aim of this study was to demonstrate the long-term safety and effectiveness of a new approach named the loop technique for patients who experience repeated intraoperative transvenous LV lead dislocations during CRT.

Methods

The current study was a single-centre, prospective, nonrandomized controlled trial. Forty-four HF patients who underwent CRT were included. All patients were followed to death or 3 years.

Results

Among 44 HF patients, 36 underwent the traditional operation, and 8 underwent the loop technique due to repeated intraoperative LV lead dislocations. Intergroup comparison revealed no significant differences between the two groups with respect to most preoperative indices, intraoperative pacing and sensing parameters. At the end of the 3-year follow-up, 4 (11.1%) patients in the traditional operation group and 2 (25.0%) patients in the loop technique group had died. There was no significant difference in the mortality rate (P = 0.30). No complications related to this new technique were observed, such as intracoronary thrombosis, infection or dislocation. Intergroup comparison showed no significant difference in the New York Heart Association (NYHA) class, echocardiography indices, N-terminal pro brain natriuretic peptide (NT-proBNP) level or pacemaker programming parameters.

Conclusions

The loop technique is a safe and effective alternative method for patients who experience repeated intraoperative transvenous LV lead dislocations during CRT.
Impact of pulmonary artery pressure on recurrence after catheter ablation in patients with atrial fibrillation
Authors: Choi Yun Young , Choi Jong-Il , Jeong Joo Hee , Lee Hyoung Seok , Kim Yun Gi , Kim Mi-Na , Roh Seung-Young , Shim Jaemin , Kim Jin Seok , Park Seong-Mi , Kim Young-Hoon
Published: September 2023

Background

The pulmonary veins play a major role in the pathogenesis of atrial fibrillation (AF) and may be affected by cardiac remodeling due to pulmonary vascular dysfunction. It remains to be determined whether pulmonary artery pressure (PAP) is associated with the recurrence of AF after radiofrequency catheter ablation (RFCA).

Methods

Consecutive patients with paroxysmal and persistent AF who underwent RFCA, including wide circumferential pulmonary vein isolation, were analyzed. Systolic PAP was measured using transthoracic echocardiography, and clinical outcomes were compared between patients with PAP <35 mmHg and those with PAP ≥35 mmHg.

Results

Among 2,379 patients (mean age 56.7 ± 10.6 years, 77% men), 1,893 (79.6%) had PAP <35 mmHg and 486 (20.4%) had PAP ≥35 mmHg. During the median follow-up of 25.4 months, in patients with paroxysmal AF (n = 1,294), the recurrence rate was significantly greater in the PAP ≥35 mmHg group than in the PAP <35 mmHg group (35.1% vs. 23.8%, log-rank p = 0.008). However, in patients with persistent AF (n = 1,085), the recurrence rate was not significantly different between the two groups (52.2% vs. 49.7%, log-rank p = 0.409). Multivariate analysis using Cox regression showed that PAP ≥35 mmHg was significantly associated with clinical recurrence (hazard ratio 1.19, 95% confidence interval 1.02–1.40, p = 0.027).

Conclusion

This study showed that a higher PAP was associated with an increased risk of recurrence after RFCA in patients with paroxysmal AF, suggesting a mechanism by which a pulmonary vascular pathology may cause impairment of the pulmonary veins and remodeling of the left atrium.
Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin
Authors: Andersen Thomas , Ueland Thor , Aukrust Pål , Nilsen Dennis W.T. , Grundt Heidi , Staines Harry , Pönitz Volker , Kontny Frederic
Published: September 2023

Background

Extracellular matrix (ECM) is an integral player in the pathophysiology of a variety of cardiac diseases. Cardiac ECM is composed mainly of collagen, of which type 1 is the most abundant with procollagen type 1 N-terminal Propeptide (P1NP) as a formation marker. P1NP is associated with mortality in the general population, however, its role in myocardial infarction (MI) is still uncertain, and P1NP has not been investigated in acute chest pain. The objective of the current study was to assess the role of P1NP in undifferentiated acute chest pain of suspected coronary origin.

Methods and results

813 patients from the Risk in Acute Coronary Syndromes study were included. This was a single-center study investigating biomarkers in consecutively enrolled patients with acute chest pain of suspected coronary origin, with a follow-up for up to 7 years. Outcome measures were a composite endpoint of all-cause death, new MI or stroke, as well as its individual components at 1, 2, and 7 years, and cardiac death at 1 and 2 years. In multivariable Cox regression analysis, quartiles of P1NP were significantly associated with the composite endpoint at 1 year of follow-up with a hazard ratio for Q4 of 1.82 (95% CI, 1.12–2.98). There was no other significant association with outcomes at any time points.

Conclusion

P1NP was found to be an independent biomarker significantly associated with adverse clinical outcome at one year in patients admitted to hospital for acute chest pain of suspected coronary origin. This is the first report in the literature on the prognostic value of P1NP in this clinical setting.

Clinicaltrials.ygov Identifier

NCT00521976.