bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute kidney injury in children and adolescent poisoning – prevalence, etiology and risk factors
Authors:   “Grigore Alexandrescu” Emergency Children’s Hospital, Bucharest, Romania, Ulmeanu Alexandru-Ioan , Bizo Aurel ,   Emergency Children’s Hospital, Cluj-Napoca, Romania, Ulmeanu Coriolan ,   “Grigore Alexandrescu” Emergency Children’s Hospital, Bucharest, Romania
Published: July 2022

Objectives. The incidence and prevalence of renal disease in actual children poisoning is not fully known because renal structural and functional changes caused by nephrotoxins are nonspecific and toxic etiology is often overshadowed. This study aims to assess the prevalence of toxic nephropathies in a pediatric population, the etiology, clinical and laboratory aspects, prognostic factors, frequency of use of extra renal epuration techniques and their impact on survival. Materials and methods. We conducted an observational, retrospective, multicentric study, over a period of 10 years, between 2003 and 2012, on 82 patients aged 0-18 years from two pediatric poison centers: the department of Toxicology SCUC “Grigore Alexandrescu” Bucharest and the Department of Pediatric Nephrology and Toxicology at the Emergency Clinical Hospital for Children in Cluj-Napoca. In the study group were included patients with acute intoxication who presented acute kidney injury defined by the AKIN criteria. Results. The etiology of poisoning that have associated acute kidney injury is dominated by drugs – 36.6%, followed by mushrooms – 24,4%, insecticides – 18.3% and alcohols – 11%. In smaller percentages we noted poisonings with caustic substances, hydrocarbons, nitrites and lead. Looking in detail we can observe that for the etiology of drug poisonings multidrug intoxications prevailed followed by poisonings with antibiotics most commonly gentamicin. In the case of multi drug poisonings the substances most frequently involved were: combination of Paracetamol, NSAIDs and Metamizol. In mushroom poisonings, in most cases were involved mushrooms with long incubation period probably Amanita Phalloides. For the Insecticide poisonings the etiology was represented mainly by organophosphorus and carbamate insecticides. The etiology of alcohol poisoning most commonly included cases of ethylenglycol. On the group of 82 cases studied, 26 deaths were recorded, mortality was 32%. We observed that oliguria, anuria, edema, hemorrhagic manifestations, polypnea, signs of shock, coma, and hepatic hepatocytolisis were risk factors for death in our study. The methods of extrarenal epuration or renal replacement treatment were carried out in 41% of cases. They were not protective factors in the study group. Conclusions. Acute poisoning cases in children show a significant increase in recent years in our country. The cases of toxic acute renal injury often have severe prognosis. Associated risk factors should be identified and diagnosed quickly to establish aprioritized early and effective treatment.
Possibilities and limits of therapy in a case of hypochondroplasia
Authors:   II Pediatric Clinic, “Gr. T. Popa” Medicine and Pharmacy University, Iasi, Romania, Alexoae Monica , Rugina Aurica ,   II Pediatric Clinic, “Gr. T. Popa” Medicine and Pharmacy University, Iasi, Romania, Moraru Evelina ,   II Pediatric Clinic, “Gr. T. Popa” Medicine and Pharmacy University, Iasi, Romania, Ioniuc Ileana ,   II Pediatric Clinic, “Gr. T. Popa” Medicine and Pharmacy University, Iasi, Romania
Published: July 2022

Hypocondroplasia is an autosomal dominant genetic disease caused by mutations in the receptor 3 of the fibroblast growth factor gene. The short stature’s negative impact on quality of life can be improved by early diagnosis and prompt recombinant growth hormone therapy. The authors present the case of a teenager who lost the chance of this therapy because of a late diagnosis.
Assessment of insulin administration among diabetic patients in India- a review article
Authors: Antony Nimitha , Ashok Pavithra , PS Muhammad Abdul Khadir , Jetto Dona Maria
Published: July 2022

Background and aim: To conduct a descriptive review and synthesize data from all studies assessing the knowledge, attitude, practice, and adverse events of insulin administration and storage techniques in patients with diabetes in India.

Methods and Materials: Literature search regarding the knowledge, attitude, practice, and adverse events of insulin administration were performed using the Google Scholar search engine as well as Pub Med up to December 2021.

Results: A total of 14 studies were selected which were published from 2014 to 2021. About six of the studies was cross-sectional and the other six of them included cross-sectional, observational survey through a questionnaire. The sample size was around 55-750 and the age range was 30-70 years. A higher level of knowledge and economic status improved insulin administration among the patients. The younger population had a more positive attitude towards insulin administration than the older patients. Insulin practices as well as the adverse events followed by the insulin administration were assessed.

Conclusion: The study is a review to examine the knowledge, attitude, practice, adverse events, and storage of insulin among diabetic patients. Diabetes education must be provided to patients as well as health care providers for improved clinical practices of insulin.
Knowledge, attitude & practice (KAP) of diabetes in Berhampur, Odisha, India- An observational study
Authors: Hotta Santanu Kumar , Pradhan Amitraj , Mahalik ), Lopamudra
Published: July 2022

Diabetes mellitus type -2 is a silent disease and a group of metabolic disorders which results high blood glucose level for a long period due to lack of insulin production ,less insulin action now recognized as one of the fastest growing chronic disease   to public health in almost all countries of the world and leading cause of Morbidity and Mortality. Positive knowledge, Attitude, Practice (KAP) are important for Diabeties patients and the level of awareness of general population is needed. The present study is planned with the aim to determine the level of K AP about T2DM among diabetic patients in a urban settings of Berhampur, at M.K.C.G. Medical college & hospital, Ganjam, Odisha, India. The study was conducted at M.K.C.G. Medical College & Hospital, Berhampur, Ganjam, Odisha which is a field practice area of Department of Endocrinology. The study was conducted between 1st may and 15th may. KAP study is an important parameter to validate the awareness about Diabetes mellitus type-2 .Need for the study is required To assess the knowledge and knowledge on practice of self care management of patients with diabetes mellitus. KAP(Knowledge,Attitude,Practice )The Institutional Ethics Committee clearance was duly sought before the conduct of study. Attitude and Practice questionnaire was prepared as described after establishing its validity of the patients. Mean score of KAP of Type-II Diabetes mellitus is calculated from the questionnaire prepared for KAP Studies.
Impact of Covid-19 Pandemic on the Perception of Orthodontic Treatment Needs Among Dental Fraternity
Authors:   Coorg Institute of Dental Sciences, Virajpet, Karnataka, Misra Parnika , Goutham B ​ , Muddaiah Sunil , Susil Vikram
Published: July 2022

With COVID-19 declared as a worldwide pandemic, a nationwide lockdown was implemented overnight in India on March 24, 2020. This posed many challenges to the orthodontic practice that requires periodical and regular appointments to ensure appropriate results. Since orthodontic treatment often takes long period of time ranging from 12 to 18 months or even longer, patients undergoing Orthodontic treatment were affected as institutions and clinics were indefinitely closed. The participants were asked to fill out an online questionnaire using google forms and the responses submitted were analysed to note the changes in the perception of orthodontic treatment since the start of the pandemic and implementation of compulsory face covers. The study conducted was purely perspective based wherein the popular opinion was taken and conclusions were drawn on the basis of the same. The results indicated that masks seemed to reduce the consciousness of the patients, and they seemed to have become more inclined to undergo orthodontic treatment with metallic brackets now being a popular choice. Keywords: COVID­19, Masks, Braces, Metallic brackets, Orthodontic treatment
Management of Feeding Problems in Infants with Cleft Palate and Review on Pierre-Robin Syndrome
Authors:   Department of Prosthodontics, Maulana Azad Institute of Dental Sciences, India, Deepika Kumari , Bhatnagar Atul , Bansal Rajesh , Verma Aprajita
Published: July 2022

Pierre Robin syndrome is a congenital disorder with triad of features micrognathia, glossoptosis which result in airway obstruction and feeding difficulties and cleft palate. Cleft palate is the most common congenital anomalies of craniofacial region seen in Pierre-Robin syndrome. Infants with cleft palate have to face various problems. Difficulty in feeding is the most common problem faced by cleft palate neonates that made them difficult to maintain adequate nutrition, result in failure to thrive. There are many methods given in literature to overcome this problem including special type of nursing bottles. In this case report, fabrication of feeding plate to obturate the defect in palate and its use in managing feeding problem is described. Keywords: ­Cleft palate, Feeding plate, Pierre­Robin Syndrome
Combined Resective and Regenerative Therapy - A Novel Approach in the Management of Furcation Involvement: A Case Report
Authors:   Department of Periodontology, Yenepoya Dental College, Yenepoya (Deemed to be) University, Mangalore, Karnataka, 575018, India, Ganesh Amruth , Madhurkar Jyosthna Ganapathi , Hegde Shashikanth , Bhat Sneha , Jenifer Haziel
Published: July 2022

Periodontal furcation involvement represents a challenge in the treatment of periodontally compromised molars. Different treatment modalities are advocated in the treatment of FI including non-surgical therapy, resective and regenerative treatment, according to subject and site factors and degree of involvement of individual affected molars. The aetiology of FI include anatomic factors, extension of inflammatory periodontal disease, trauma from occlusion, pulpo periodontal disease and root fracture involving furcations. An emerging approach to periodontal therapy is a concept of regeneration. In this case report a novel combination therapy of a blend of platelet rich fibrin with bone graft was used in the management of grade III furcation involvement. Results showed successful outcome in terms of esthetics and function. Keywords: Root resection, Furcation involvement, Bone graft, PRF
Enfermedades causadas por bacterias
Authors: Tsubota Masanobu , Angel Carlos Ariel , Leguizamón Jairo Eduardo
Published: July 2022

Los síntomas más comunes de las enfermedades causadas por bacterias en orquídeas son las pudriciones y las manchas foliares blandas o húmedas, ya que por ser suculentas, poseer tejidos gruesos y un abundante contenido de agua, se constituyen en un excelente medio para el crecimiento de bacterias. En este capítulo, se describen las bacterias causantes de enfermedades en /Cattleya/ spp. Lindl., teniendo en cuenta la revisión de literatura y los principales resultados obtenidos en las investigaciones realizadas en Cenicafé. Esta parte incluye: /Ácidovorax avenae/ subsp. /cattleyae/ (Pavarino) Savulescu; /Pseudomonas aeruginosa/ (Schroeter) Migula y /Pseudomonas fluorescens/ Migula; /Erwinia carotovora/ subsp. /carotovora/ (Jones) Bergey et al; Manejo de enfermedades bacterianas.
Enfermedades causadas por nematodos
Authors: Tsubota Masanobu , Angel Carlos Ariel , Leguizamón Jairo Eduardo
Published: July 2022

La información que hace referencia a la presencia de nematodos parásitos en /Cattleya/ spp., indica la existencia de dos especies: una que causa principalmente lesiones en las inflorescencias y la otra, lesiones en las raíces. Esta información está basada sólo en la revisión de literatura e incluye el siguiente contenido: Aspectos generales; /Aphelenchoides ritzema-bosi/ (Schwartz) Steiner y Buhrer; /Pratylenchus pratensis/ (De Man) Filip; otros registros; manejo de nematodos.
EXPERIMENTAL INVESTIGATIONS ON INNOVATIVE CRACK REPAIR METHODS AND REINFORCING STEEL STRUCTURES WITH ADHESIVLY BONDED CFRP – LAMELLAS
Authors: Sternsdorff Florian , Ciupack Yvonne , Pasternak Hartmut
Published: July 2022

The paper describes some of the experiments carried out at the Chair of Steel and Timber Construction to reinforce steel with adhesively bonded CFRP lamellas.
The first topic deals with the repair of cracks in steel structures exposed to fatigue. The aim was to extend the remaining service life of these components by means of adhesively bonded CFRP lamellas and then to compare the results obtained with established methods for repairing cracks. In order to improve the informative value of the investigations, several test parameters such as adhesive candidates, temperature, creep effects, degrees of prestressing, load levels and the position of the reinforcement measures were varied.
The second set of topics examined the extent to which a typical steel beam-to-column connection can be reinforced with the help of adhesively bonded CFRP lamellas.
THE INTERCONNECTEDNESS OF STOCK PRICES, MONEY, AND CREDIT ACROSS TIME AND FREQUENCY FROM 1970 TO 2016
Authors: Ryczkowski Maciej , Zinecker Marek
Published: July 2022

This article applies continuous wavelet and maximal overlap discrete wavelet transforms to study the co-movements and the direction of causality between money (M3 and M2), bank credit, credit from all sectors vs. stock price dynamics across time and frequency for 12 developed countries. The time-varying linkages were significant typically for credit rather than money developments. Particularly, these linkages appeared during phases of house and stock price boom and bust at a business cycle frequency. The discovered lead-lag patterns give relatively much time for monetary policy authorities to support their financial stability objectives by imposing restrictions on credit. Closing the channel through which credit and stock prices interact may counteract the rising financial imbalances. This finding holds also for the euro area where the monetary pillar is based on broad money. The new application of wavelets allowed discovering the varying linkages that were not necessarily evident in the standard methods of analysing data.
Constraining Annihilating Dark Matter by the Radio Continuum Spectrum of the Large Magellanic Cloud
Authors: Chan Man Ho , Lee Chak Man
Published: July 2022

Recent radio observations have obtained stringent constraints for annihilating dark matter. In this article, we use the radio continuum spectral data of the Large Magellanic Cloud to analyze the dark matter annihilation signals. We have discovered a slightly positive signal of dark matter annihilation with a 1.5σ statistical significance. The overall best-fit dark matter mass is m
DM ≈ 90 GeV, annihilating via the

b

b

¯

channel. We have also constrained the 3σ lower limits of dark matter mass with the standard thermal dark matter annihilation cross section for the e
+
e
−, μ
+
μ
−, τ
+
τ
−, and

b

b

¯

channels.
4–8 GHz Fourier-domain Searches for Galactic Center Pulsars
Authors: Suresh Akshay , Cordes James M. , Chatterjee Shami , Gajjar Vishal , Perez Karen I. , Siemion Andrew P. V. , Lebofsky Matt , MacMahon David H. E. , Ng Cherry
Published: July 2022

The Galactic Center (GC), with its high density of massive stars, is a promising target for radio transient searches. In particular, the discovery and timing of a pulsar orbiting the central supermassive black hole (SMBH) of our galaxy will enable stringent strong-field tests of gravity and accurate measurements of SMBH properties. We performed multiepoch 4–8 GHz observations of the inner ≈15 pc of our galaxy using the Robert C. Byrd Green Bank Telescope in 2019 August–September. Our investigations constitute the most sensitive 4–8 GHz GC pulsar survey conducted to date, reaching down to a 6.1 GHz pseudo-luminosity threshold of ≈1 mJy kpc2 for a pulse duty cycle of 2.5%. We searched our data in the Fourier domain for periodic signals incorporating a constant or linearly changing line-of-sight pulsar acceleration. We report the successful detection of the GC magnetar PSR J1745−2900 in our data. Our pulsar searches yielded a nondetection of novel periodic astrophysical emissions above a 6σ detection threshold in harmonic-summed power spectra. We reconcile our nondetection of GC pulsars with inadequate sensitivity to a likely GC pulsar population dominated by millisecond pulsars. Alternatively, close encounters with compact objects in the dense GC environment may scatter pulsars away from the GC. The dense central interstellar medium may also favorably produce magnetars over pulsars.
Viability of Novae as Sources of Galactic Lithium
Authors: Kemp Alex J. , Karakas Amanda I. , Casey Andrew R. , Côté Benoit , Izzard Robert G. , Osborn Zara
Published: July 2022

Of all the light elements, the evolution of lithium (Li) in the Milky Way is perhaps the most difficult to explain. Li is difficult to synthesize and is easily destroyed, making most stellar sites unsuitable for producing Li in sufficient quantities to account for the protosolar abundance. For decades, novae have been proposed as a potential explanation for this “Galactic Li problem,” and the recent detection of 7Be in the ejecta of multiple nova eruptions has breathed new life into this theory. In this work, we assess the viability of novae as dominant producers of Li in the Milky Way. We present the most comprehensive treatment of novae in a galactic chemical evolution code to date, testing theoretically and observationally derived nova Li yields by integrating metallicity-dependent nova ejecta profiles computed using the binary population synthesis code binary_c with the galactic chemical evolution code OMEGA+. We find that our galactic chemical evolution models which use observationally derived Li yields account for the protosolar Li abundance very well, while models relying on theoretical nova yields cannot reproduce the protosolar observation. A brief exploration of physical uncertainties including single-stellar yields, the metallicity resolution of our nova treatment, common-envelope physics, and nova accretion efficiencies indicates that this result is robust to physical assumptions. Scatter within the observationally derived Li yields in novae is identified as the primary source of uncertainty, motivating further observations of 7Be in nova ejecta.
Long Term Efficacy of Generic Atorvastatin by a University Hospital Database
Authors: Manasirisuk Panisa , Chainirun Nanthaphan , Tiamkao Somsak , Lertsinudom Sunee , Phunikhom Kutcharin , Sawanyawisuth Kittisak
Published: July 2022

Background: There is limited long term data of generic atorvastatin in terms of clinical efficacy and safety. This study aimed to evaluate the efficacy of generic atorvastatin in a 12-month period.
Methods: This study was a retrospective cohort study. The inclusion criteria were adult patients who received the original atorvastatin for at least three months and then switched to the generic atorvastatin for 12 months. Lipid profiles and safety profiles were evaluated after 12 months of switching therapy.
Results: During the study period, there were 297 patients met the study criteria. The mean (SD) age of the patients was 61.05 (11.51) years. Male sex accounted for 46.80% (139 patients). For lipid outcomes, only HDL-c was significantly increased by 2.05 mg/dL (p 0.001). Serum creatinine was increasing by 0.07 mg/dL, while eGFR was decreasing by 2.55 ml/min/1.73m2. Other laboratory outcomes were not significantly changed after one year including ALT, AST, and CK.
Conclusions: Generic atorvastatin had comparable effect on LDL-c reduction compared with the original atorvastatin. Renal deterioration were found with increasing HDL-c level in this study population with generic atorvastation. Physicians should be aware of declining of renal function in long term use of generic atorvastatin.
Assessment of Knowledge and Practices toward Salt Intake among Adolescents
Authors: Hagag Suzan , Habib Eman , Tawfik Safaa
Published: July 2022

Background:High salt intake is linked to risk of development of renal disease, stomach cancer and osteoporosis.Raised BP typically present in adulthood but its origin commonly begins in childhood.The aim of this study is toassess of knowledge and practices towards salt intake among adolescents.Methods: This was a cross – sectional that carried out in Mansoura governorate. A convenience sample of 240 adolescents between 12 -17 years was taken from community recreation places and clubs. A Pre tested questionnaires were developed to assesssociodemographic characteristics, knowledge towards salt consumption, knowledge towards salt hazards and trials to control salt consumption.A modified food frequency questionnaire was used to assess their nutritional practices.Results:Nearly half of study group was aged 14-15 years(40.9%).Nearly two third of study participants was females (64.2%) and three quarter was from urban areas (75%).More than half of study group believed to consume moderate amount of salty food (57.1 %), and about half of them had good knowledge about salt harms and value of reduction of salt consumption (50.8% & 53.3% respectively),.Unfortunately majority of them did not attempt any trial of mentioned trials to control their salt intake. Only less than 50 % try to minimize outdoors food and processed food consumption.
Conclusion:Although study participants knew the harm of salt consumption, unfortunately majority of them did not attempt any trial of mentioned trials to control their salt intake.
Recommendations: These findings highlighted the importance of nutritional counseling among adolescents towards healthy eating practices
Key words
Salt Intake-Knowledge-Practices-Adolescents
The Influence of Organizational Justice and Prosocial Behavior toward Empathy on the Care of Islamic Religious Patients with Welfare Moderators
Authors: Basirun Muhammad , Haryono Suyono , Mustofa Zaenal , Prajoogo Wisnu
Published: July 2022

BACKGROUND: Individuals in organizations behave and empathize in several studies can be influenced by organizational policies, including their welfare; this has indeed been widely studied. Even so, a firm answer is needed as to whether empathy is affected by organizational justice along with well-being and also whether empathy is influenced by prosocial behavior to increase empathy? This research unequivocally answers this question.

AIM: The aim of this study is to know the effect of organizational justice on empathy, knowing whether welfare moderates the influence of organizational justice variables on empathy, knowing whether prosocial behavior affects empathy, and knowing whether welfare moderates the effect of prosocial behavior on empathy.

METHODS: This study uses a quantitative survey research method and data collection by cross-sectional research with a sample of 226 inpatient nurses at Muhammadiyah Hospital type B throughout Indonesia. The sample used is a probability sampling model. Data analysis is done using Structural Equation Modeling (SEM) AMOS 22.00.

RESULTS: Ha1 test results, p = 0.032; this has a significant meaning. Ha2 is the interaction value 1: p = 0.001, which means that 1 is significant interaction, Ha3 p = 0.011 with welfare moderation, which has a significant meaning, and Ha4 interaction 2, welfare on the effect of prosocial behavior on empathy the value is p = 0.001, which means it is significant.

CONCLUSIONS: (1). Organizational justice has a positive effect on empathy, (2). welfare moderates the positive effect of organizational justice on empathy, (3). prosocial behavior has a positive effect on empathy, (4). welfare moderates the effect of prosocial behavior on empathy.
The Role of Forensic Science in Criminal Acts of Murder Cases in Indonesia
Authors: Halim Al , Indarti Erlyn , Santoso Budi
Published: July 2022

BACKGROUND: As a science of conducting examinations and collecting physical evidence found at the crime scene and then presented in court, forensic science has a critical role in the judicial process of examining the crime scene. As this usually occurs in large cases, a forensic expert only comes to crime scene at the request of the authorities.

AIM: This present study aims to find out the role of forensic science in uncovering the identity and causes of death of victims of murder and to find out the obstacles arise and the efforts that can be made in the process of uncovering the crime of murder.

METHODS: This study revealed that the usual forensic stages include collection, protection, analysis, and presentation. Forensic science in uncovering crimes is very necessary.

RESULTS: This aims to minimize the occurrence of wrong sentences, wrong arrests, and assist the performance of law enforcers in determining the perpetrators of crimes. In every handling of a murder incident, both in the processing of crime scene and in determining the crime scene, it does not rule out the possibility that the investigator experiences difficulties or there is something that applies in processing the crime scene of a murder case.

CONCLUSION: In the future, law enforcers must get an understanding of its importance in studying forensic medicine in uncovering crimes, mainly concerning human victims because it is related to the rights of victims whose lives have been forcibly confiscated by the perpetrator.
Anticancer Potential of Cinnamon Bark Extract (Cinnamomum burmanii) with Cisplatin Combination against P-glycoprotein and Apoptotic Influx Biomarkers
Authors: Dina Sarah , Siregar M. Fidel Ganis , Jusuf Nelva K. , Hasibuan Poppy Anjelisa , Andrijono Andrijono , Bachtiar Adang , Lumbanraja Sarma N. , Nasution Iqbal Pahlevi
Published: July 2022

Objective: To prove the effect of the combination of cinnamon bark extract with cisplatin in reducing efflux and increasing influx in SKOV3 ovarian cancer cell cultures by measuring the expression of p-glycoprotein, CTR1 and the annexim V.
Methods: This research is an experimental study using SKOV3 ovarian cancer cells stored in the SCTE IMERI FKUI Laboratory, carried out in the Stem Cells and Tissues Engineering Research Cluster laboratory. The cells were then harvested by adding trypsin-EDTA to the culture as much as 1 mL, and rotated at 2000 rpm for 5 minutes. Then the cells were added with antibodies and dissolved with a stain buffer solution and read on a flow cytometry device. We used ethyl acetate extract from cinnamon bark against the SKOV3 cell line . IC50 of Cinnamon bark extract we got from MTS test. We tested the levels of IC50, 3/4 IC50, 1/2 IC50, and 1/4 IC50 of cinnamon bark extract with a combination of IC50, 3/4 IC50 , 1/2 IC50, and 1/4 IC50 cisplatin against the viability of the SKOV3 cell line with single cisplatin IC50 comparator. We also examined the levels of annexin V as a marker of apoptosis in the SKOV3 cell line to see if the cell cycle arrest induced by cinnamon bark extract could cause apoptosis of the SKOV3 cell line. We assessed the sample distribution using the Shapiro-Wilk test because of the sample size . To assess the comparison of parameters (differences in p Glycoprotein and CTR-1 expression between treatment groups in normally distributed data, the test was used analysis of variance (ANOVA). ANOVA is a comparative test to analyze the difference in the mean (mean) of data from two or more variables in the same population. The Bonferroni test was used to analyze the same or different samples (equal and unequal) in each treatment.
Results: From this study, it was found that the combination of IC 50 cinnamon bark extract and IC 50 cisplatin was able to lower p-glycoprotein levels higher with a lower mean value than the other treatment groups with p<0.001. In the test group, the lowest p-glycoprotein expression was found in the combination 1 test group, namely the 1 x IC50 combination. The value of p-glycoprotein expression in the combination group 1 was 1.20%. As for CTR 1, the combination of IC 50 cinnamon bark and IC 50 cisplatin, had the highest CTR1 levels among the three other treatment groups, with p > 0.001. In the test group, the highest CTR1 expression was found in the combination 1 test group, namely the 1 x IC50 combination. The value of CTR1 expression in the combination group 1 was 12%.
Conclusion: The combination of cinnamon bark extract with cisplatin was shown to reduce efflux by decreasing p-glycoprotein expression and increasing influx by increasing CTR1 expression in SKOV3 ovarian cancer cell cultures.
Propolis Mitigates Rifampicin/Isoniazid-induced Lipid-redox and Metabolic Profile in an Experimental Animal Model of Oxidative Stress
Authors: Abdulsallam Ahmed , Thanoon Imad A. , Dawood Rwqaya S. , Abduljabbar Abdulrahman I.
Published: July 2022

Objective: Adverse drug reactions are the most common cause of drug withdrawal in chronic treatment settings. Tuberculosis (TB) has been considered a recurrent and relapsing disease that needs long-term therapy. Most patients suffer from the adverse effects of TB therapy. Hence, various remedies were used to tackle these adverse effects including antioxidant vitamins, herbal remedies, and others. Aims: The present intervention study aims to investigate the role of propolis in protecting the animal model against oxidant/antioxidant induced by TB therapy together with the propolis role in modulation of metabolic profile as part of lipid peroxidation context. Methods: Serum was collected from rats exposed to rifampicin/isoniazid with or without propolis therapy alongside the control placebo group for comparison. Results: The results have shown a significant (p<0.05) reduction of malondialdehyde and significant (p<0.05) elevation of total antioxidant status. Lipid profile positively improved indicated by significantly reduced total cholesterol, triglyceride, and elevated high-density lipoprotein. Conclusion:  our study confirmed that propolis provides protection against redox and metabolic derangement induced by rifampicin/isoniazid medications which are in current TB therapy, therefore, we do advise the use of propolis as an adjunct therapy for patients on such medications.
TORCH, Anti-cardiolepin, and Anti-phospholipids in Women with Repeated Miscarriage in Mosul City
Authors: Aldabbagh Karam A. , Alnori Mohammed KJ. , Almola Khalid W.
Published: July 2022

Abstract
 
Background and Objective: The present study aimed to identify a connection between common viral infections and women who had repeatedly miscarriages.
Material and Methods: This study is a retrospective study which has been carried out on 2010 records in Mosul city/Iraq, and the patients were all women of child-bearing age (20-35 years old). All of the women had suffered from an abortion at least once before. The target viruses in charge for this study include; Toxoplasma gundi, Cytomegalovirus, Rubella virus, and Herpes virus.
Results and Conclusion: The analysis is based on the detection of the anti-bodies which confirmed a negative correlation between antibodies level and active viral infection, together with no clear association between the presence of active infectious status and miscarriage. Additionally, only few positive cases for each individual patient were positive for viral infection.  Hence, the outcome confirmed no clear association between presence of infectious agent and repeated miscarriage. Nonetheless, rubella and cytomegalovirus have shown the highest contribution in this regard.
Expeausition
Authors: Chassagnol Anne
Published: July 2022

Comment comprendre que le tatouage ne soit plus une marque de résistance mais soit désormais investi d’une valeur esthétique ? Il s’agit de graver un moment signifiant de la vie de l’individu, de faire corps dans les ruines du monde moderne, mais aussi de raconter une histoire, empruntant à l’iconophagie et constituant un étonnant ego-musée.
La poétique des reliques de Michel Deguy
Authors: Suzzoni Cécilia
Published: July 2022

L’œuvre de Michel Deguy, récemment disparu, est un retour sur la Fable : une poétique des reliques, au cœur de laquelle on trouve une dialectique de fidélité et de trahison. Toutes les archives des croyances perdues sont traduites dans la fragilité du poème.
Le jeu au service de la symbolisation dans l’expérience de la maladie -d’Alzheimer. Apport du Scéno-Test
Authors: Fourques Catherine
Published: July 2022

La démarche de présentation du Scéno-test à des personnes âgées souffrant de la maladie -d’Alzheimer est encore exploratoire. L’étayage sensoriel des objets inscrits dans une aire transitionnelle d’expérience soutient le déploiement de capacités de symbolisation et d’investissement narcissique dans le plaisir à faire et à penser. Le jeu, dans l’engagement corporel et les modalités relationnelles qu’il propose ranime la subjectivité de la personne âgée malade dans sa complexité révélant à la fois des points de vulnérabilité dans l’échec des processus de régulation et des potentialités en soulignant la cohabitation de problématiques narcissiques et psychosexuelles.
Symbolisation des enjeux familiaux à travers l’association du tat et de la Libre Réalisation de l’Arbre Généalogique ( LRA g)
Authors: Hatim-Porcuna Camille , Le Chevanton Tristan , Béraud Paul
Published: July 2022

Le présent travail vise à introduire la complémentarité des deux médiations projectives que sont le tat et la Libre Réalisation de l’Arbre Généalogique ( lra g) tant pour leur pertinence dans l’étude du fonctionnement psychique individuel et de la résonance des enjeux familiaux, qu’en tant qu’opérateur de la relance du travail de symbolisation sous-tendant le processus de subjectivation ; ici mis à mal chez un patient auteur de violences hétéro-agressives hospitalisé en umd . L’association de ces deux outils se base sur leur potentialité de mise en représentation des liens familiaux et de l’inscription subjective qui, inscrits dans un dispositif médiatisé permettrait l’accès au processus symbolisant des vécus psychiques.
Quel périmètre pour des statistiques sur l’économie sociale à l’échelle internationale ?
Authors: Bouchard Marie J. , Chaves Rafael
Published: July 2022

Bien que partageant un socle commun, le périmètre statistique de l’économie sociale (ES) varie d’un pays à l’autre. Dans de nombreux pays, l’ES demeure entièrement sous le radar des agences statistiques. Ceci reflète le déploiement historique et progressif de l’ES dans différents contextes nationaux. Des guides ont été développés pour promouvoir et harmoniser les statistiques de différents sous-ensembles de l’ES à l’échelle internationale. Récemment, l’un de ces guides a proposé de couvrir l’ensemble. Il en a toutefois exclu un bon nombre de coopératives et y a introduit des entités privées à finalité lucrative. Cet article s’intéresse au débat que cette situation suscite quant à la vision de l’ES véhiculée par ses représentations statistiques.
Les conséquences de la crise économique sur l’évolution du système de crédit coopératif grec
Authors: Karafolas Simeon
Published: July 2022

Cet article présente les conséquences de la longue crise économique qui a touché la Grèce sur l’évolution du système de crédit coopératif. Les banques coopératives ont été confrontées à d’importants problèmes d’adéquation des fonds propres. Contrairement aux banques systémiques, les banques coopératives n’ont pas bénéficié d’une aide publique pour l’augmentation de leur capital coopératif. Certaines des banques coopératives n’ont pas réussi à atteindre le capital nécessaire et elles ont dû cesser leur activité. Le système bancaire coopératif grec est ainsi entré dans une nouvelle phase avec moins de banques, mais avec une base de fonds propres plus solide et la volonté d’une plus grande coopération entre elles.
Threshold behaviour of a triple-delay SIQR stochastic epidemic model with Lévy noise perturbation
Authors: Liu Yubo , Kuang Daipeng , Li Jianli
Published: July 2022

In this paper, the dynamical behavior of a delayed SIQR stochastic epidemic model with Lévy noise is presented and studied. First, we prove the existence and uniqueness of positive solution. Then, we establish the threshold $ R_0^l $ as a sufficient condition for the extinction and persistence in mean of the disease. Finally, some numerical simulations are presented to support our theoretical results and we infer that the white and Lévy noises affect the transmission dynamics of the system.
The construction of solutions to $ {}^{C} \mathit{\boldsymbol{{D}}}^{(1/n)} $ type FDEs via reduction to $ \left({}^{C} \mathit{\boldsymbol{{D}}}^{(1/n)}\right)^n $ type FDEs
Authors: Marcinkevicius R. , Telksniene I. , Telksnys T. , Navickas Z. , Ragulskis M.
Published: July 2022

A scheme for the integration of $ \, {}^{C} \mathit{\boldsymbol{{D}}}^{(1/n)} $-type fractional differential equations (FDEs) is presented in this paper. The approach is based on the expansion of solutions to FDEs via fractional power series. It is proven that $ \, {}^{C} \mathit{\boldsymbol{{D}}}^{(1/n)} $-type FDEs can be transformed into equivalent $ \left(\, {}^{C} \mathit{\boldsymbol{{D}}}^{(1/n)}\right)^n $-type FDEs via operator calculus techniques. The efficacy of the scheme is demonstrated by integrating the fractional Riccati differential equation.
Time for Hume’s Unchanging Objects
Authors: Boehm Miren , Cruz Maité
Published: July 2022

In his discussion of our idea of time in the Treatise, Hume makes the perplexing claim that unchanging objects cannot be said to endure.  While Hume is targeting the Newtonian conception of absolute time, it is not at all clear how his denial that unchanging objects are in time fits with this target.  Moreover, Hume diagnoses our belief that unchanging objects endure as the product of a psychological fiction, but his account of this fiction is also riddled with puzzling claims about our experience of unchanging objects.  In this paper, we argue that Hume’s claims are a lot less baffling and indeed, much more sophisticated than they appear.  We do so by considering his arguments as a response to Locke’s specific approach to the concept of absolute time.
Le Jeu des familles dans le roman du xixe siècle
Authors: Bernard Claudie
Published: July 2022

Médiation entre l’individu et la société, la famille apparaît comme un facteur essentiel tant dans la construction des égos que dans l’élaboration de l’ordre collectif. En un XIXe siècle où se modifient les normes et les pratiques de l’institution, le roman explore les règles, les enjeux, les dessous de cartes de celle-ci, et, misant sur la dynamique de la mêmeté et de l’altérité qui assure le renouvellement domestique et généalogique, en fait jouer les possibles.Le Jeu des familles se penche d’abord, avec Balzac puis Paul Bourget, sur les nostalgies patriarcales, qui exaltent les valeurs de la filiation et de la transmission, vecteurs de la mêmeté. Il se tourne ensuite, avec Balzac, les Goncourt et Zola, vers les atouts et les handicaps du familialisme bourgeois moderne, qui privilégie les préférences individuelles et l’alliance, point d’insertion de l’« autre ». Il examine l’utopie d’une rédemption fraternitaire proposée par George Sand et Eugène Sue, qui rêvent de faire de la famille la matrice de la cohabitation des classes et de la réconciliation des sexes. Il suit enfin, chez Edmond de Goncourt, Barbey d’Aurevilly et Elémir Bourges, la décadence des lignages et des maisonnées fin de siècle, dans lesquelles se brouillent délibérément les cartes. Convoquant de nombreux textes, fictionnels et non fictionnels, cet essai montre comment le roman répercute, repense, reconfigure l’institution, et participe ainsi à sa redéfinition.
Apprendre à coudre ou savoir consommer ?
Authors: Guillier Béatrice
Published: July 2022

Au début du xxe siècle se multiplient en France des publications illustrées destinées aux petites filles, en même temps éducatives et divertissantes. La rubrique la plus importante de ces journaux est celle dédiée aux travaux d’aiguille, qui sont, à cette époque, enseignés conjointement, à l’école et à la maison. L’objectif explicite de ces pages est de transmettre les connaissances techniques pour réaliser un modèle de vêtement, généralement en tricotant ou en cousant. Les petites réalisations sont souvent destinées aux poupées des fillettes, qui leur sont fournies par le journal comme prime d’abonnement. L’hebdomadaire propose également à l’achat les fournitures nécessaires à la réalisation des modèles, le patron mis à l’échelle ainsi que, parfois, le vêtement terminé. Les rubriques de travaux d’aiguille semblent ainsi constituer une incitation à la consommation, d’autant plus que leur contenu est difficilement accessible aux petites filles du fait de leur complexité et du peu de clarté des informations visuelles fournies. Les titres de presse pour petites filles possèdent en effet des liens commerciaux avec l’industrie du textile, et font produire les trousseaux de leurs poupées qui sont très coûteux par rapport au prix initial des poupons. Ces illustrés constituent une source privilégiée pour étudier le passage d’une injonction à la maîtrise technique qui pesait sur les femmes depuis leur plus jeune âge à une incitation à la consommation éclairée et libératrice qui domine à partir de l’après-guerre.
Pratiques féministes et queer de la microédition
Authors: Goutagny Elise
Published: July 2022

Ce portfolio présente un corpus de fanzines et microéditions féministes et queer : fanzines de la collective Bye Bye Binary, ateliers du Club Maed, éditions de la maison Les Grillages, zine-revue Mamma Rassise. La sélection d’images donne un aperçu du laboratoire graphique du genre que constituent ces productions. Issus de pratiques fondamentalement collectives et en réseau, les imprimés étudiés matérialisent une réflexion typographique et poétique sur l’écriture inclusive, en cherchant à la diversifier et à « décomplexer » son usage par des jeux de découpage. Les formes qui s’y développent se veulent irrécupérables, utopiques, hors des normes de lisibilité. Ces microéditions ont également pour vocation de faire circuler des textes militants, augmentés, traduits, et de rendre visibles des savoirs alternatifs en dehors des circuits d’édition traditionnels. Matérialisant des vécus et des savoirs, ces objets imprimés contribuent à renforcer un réseau d’adelphité féministe et queer.This portfolio presents a selection of feminist and queer fanzines and micro-publications: fanzines from the Bye Bye Binary collective, Club Maed workshops, publications from Les Grillages, and the zine Mamma Rassise. This selection of images provides an overview of the « graphic workshop on gender » that such productions constitute. Stemming from fundamentally collective and network-based practices, the works we study here materialize a typographical and poetic reflection on inclusive writing, seeking to diversify it and to "unburden" its use through the practice of papercutting and collage. The resulting forms are meant to be camp, idealistic, and outside the norms of legibility. These micro-publications also aim at promoting the circulation of activist texts, augmented and translated, and to give visibility to alternative knowledge outside the traditional channels of publishing. As embodiments of lived experience and knowledge, these printed objects contribute to strengthening a network of feminist and queer solidarity.
Les tisseuses de Ouagadougou
Authors: Fortin Laura
Published: July 2022

Entrecroisant les récits de vie de Farah, Jahia, Bernadette et Suzanne, cet article examine la pratique féminine du tissage artisanal à Ouagadougou, la capitale du Burkina Faso, et s’intéresse aux éléments qui fondent la communauté de pratique des « tisseuses ». Apparue au début du xxe siècle et répandue à partir de la fin des années 1950, la pratique féminine du tissage au Burkina Faso repose sur un apprentissage intragénérationnel, délivré entre parentes ou voisines, et non pas sur un apprentissage intergénérationnel comme c’est le cas pour beaucoup d’artisanats ouest africains, notamment la pratique masculine du tissage. Durant de quelques mois à plusieurs années, cet apprentissage est dispensé gratuitement mais il engage une relation de réciprocité entre les artisanes, fondant une économie morale caractérisée par un partage continu d’informations et de savoirs et une entraide matérielle. La socialisation féminine accompagnant la pratique renforce le partage d’une expérience genrée et favorise ainsi l’identification à la communauté des « tisseuses ». La création d’associations formelles de tisseuses à partir des années 1980 établit et institutionnalise l’existence de ce collectif. Elle culmine avec la mise en place en 2017 d’une fédération nationale des tisseuses destinées à négocier avec les instances dirigeantes du gouvernement et de la Chambre des métiers de l’artisanat pour défendre les intérêts économiques et politiques de la communauté. Mettant en évidence une hiérarchie des modes de participation, ces dynamiques, allant d’une pratique structurée en association à une activité de tissage solitaire et irrégulière, donnent à voir une diversité et une hétérogénéité de profils et de formes d’engagement qui renforcent et renouvellent en même temps cette communauté de pratique.
Accelerated Digital Transformation
Authors: Arora Deepak , Waiters Breann Alexus , Goel Lakshmi
Published: July 2022

The pandemic has accelerated the need for organizations to embrace digital strategies for processes that are both internally as well as externally facing. The demand for innovation in how a firm serves customers, supports teams, and empowers employees has necessitated the adoption of digital solutions. In this chapter, the authors provide a framework for how organizational leaders can envision digital transformation in a way that is in alignment with business strategy. Digital innovation, while left to the IT enterprise in the past, is now elevated to the level of organizational strategy and can be instrumental to business competitiveness and continuity. Strategic digital transformation can help organizations build agility and resilience, capabilities that have proven to be essential in the face of unpredictable forces, such as those experienced during the COVID-19 pandemic.
Ethics in Marketing
Authors: Bulley Cynthia A. , Braimah Stephen Mahama , Achiriga Victor
Published: July 2022

Can business and marketing practice be ethical in its entirety? The purpose of this chapter is to understand ethics in relation to marketing, examining theoretical bases and critical cases that provoked enormous controversy and sanctions. Ethics issues in marketing stem from an unconscious bias caused by equity sensitivity and certain manifestations of particular dimensions of diversity with low levels of inclusion. Notwithstanding equity, diversity, and inclusion studies stressing ethics and moral value, critically linking theories with practical issues is needed to promote good practices in marketing and business. Ethics in business and marketing improve decision-making and operations while creating credibility and satisfying stakeholders. For businesses, remaining ethical and having it entrenched in the culture of the organisation is a necessity to balance stakeholder interest. The chapter provides a window of opportunity for marketers and business practitioners to acquaint themselves with marketing ethics failures and regulatory responses.