bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S8 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation
Authors: Drasin David J. , Guarnieri Anna L. , Neelakantan Deepika , Kim Jihye , Cabrera Joshua H. , Wang Chu-An , Zaberezhnyy Vadym , Gasparini Pierluigi , Cascione Luciano , Huebner Kay , Tan Aik-Choon , Ford Heide L.
Published: March 2023

Supplementary Figure S8 Working model. MiR-424 can drive an intermediate EMT in primary breast tumors by downregulating TGFBR3, leading to increased mesenchymal characteristics concomitant with unaffected epithelial content. Experimental motility is also increased that may help facilitate tumor cell dissemination, although TIC phenotypes are repressed. Downregulation of TGFBR3 by miR-424 leads to increased ERK signaling that is required for inhibition of TIC phenotypes, which is reversible in vitro, and we hypothesize is reversed in disseminated tumor cells by decreased miR-424 to facilitate colonization.
Supplementary Figure S5 from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation
Authors: Drasin David J. , Guarnieri Anna L. , Neelakantan Deepika , Kim Jihye , Cabrera Joshua H. , Wang Chu-An , Zaberezhnyy Vadym , Gasparini Pierluigi , Cascione Luciano , Huebner Kay , Tan Aik-Choon , Ford Heide L.
Published: March 2023

Supplementary Figure S5 Global mature miR levels are not downregulated in metastatic tissue. (A) Levels of mature miR-25, -125b and -195 in SUM149PT pre-injection cells expressing EV control or miR-424. Levels of mature (B) miR-25, (C) miR-125b and (D) miR-195 in metastatic tissue formed from EV or miR-424 expressing SUM149PT cells, by qPCR. SD shown. &No remaining RNA to assay.
Supplementary Video 1 from In Vivo Tomographic Imaging of Deep-Seated Cancer Using Fluorescence Lifetime Contrast
Authors: Rice William L. , Shcherbakova Daria M. , Verkhusha Vladislav V. , Kumar Anand T.N.
Published: March 2023

Tomographic reconstruction of MTLn3-iRFP720 yield distribution in the lungs co-registered with X-Ray CT scan of the mouse.
Supplementary Figure Legends and Extended Methods from TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation
Authors: Drasin David J. , Guarnieri Anna L. , Neelakantan Deepika , Kim Jihye , Cabrera Joshua H. , Wang Chu-An , Zaberezhnyy Vadym , Gasparini Pierluigi , Cascione Luciano , Huebner Kay , Tan Aik-Choon , Ford Heide L.
Published: March 2023

Supplementary Figure Legends and Supplementary Materials and Methods
Supplementary Figure S3 from Heterochromatin Protein HP1γ Promotes Colorectal Cancer Progression and Is Regulated by miR-30a
Authors: Liu Ming , Huang Feifei , Zhang Dan , Ju Junyi , Wu Xiao-Bin , Wang Ying , Wang Yadong , Wu Yupeng , Nie Min , Li Zhuchen , Ma Chi , Chen Xi , Zhou Jin-Yong , Tan Renxiang , Yang Bo-Lin , Zen Ke , Zhang Chen-Yu , Chen Yu-Gen , Zhao Quan
Published: March 2023

Pearson's correlation scatter plot of the fold change of miR-30a and HP1g mRNA in human colorectal cancer tissues (n=38).
Supplemental Table and Figure Legends from RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells
Authors: Ilmer Matthias , Boiles Alejandro Recio , Regel Ivonne , Yokoi Kenji , Michalski Christoph W. , Wistuba Ignacio I. , Rodriguez Jaime , Alt Eckhard , Vykoukal Jody
Published: March 2023

Supplemental Table and Figure Legends. Legends for Supplemental Tables S1-S5 and Supplemental Figures S1-S8.
Supplemental Table S4 from RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells
Authors: Ilmer Matthias , Boiles Alejandro Recio , Regel Ivonne , Yokoi Kenji , Michalski Christoph W. , Wistuba Ignacio I. , Rodriguez Jaime , Alt Eckhard , Vykoukal Jody
Published: March 2023

Supplemental Table S4. List of antibodies, assays, and dilutions utilized in this study.
Supplemental Table S3 from RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells
Authors: Ilmer Matthias , Boiles Alejandro Recio , Regel Ivonne , Yokoi Kenji , Michalski Christoph W. , Wistuba Ignacio I. , Rodriguez Jaime , Alt Eckhard , Vykoukal Jody
Published: March 2023

Supplemental Table S3. List of human primer sequences used in qRT-PCR analysis in this study.
Supplementary Figure 6 from Interferon Regulatory Factor-1 Signaling Regulates the Switch between Autophagy and Apoptosis to Determine Breast Cancer Cell Fate
Authors: Schwartz-Roberts Jessica L. , Cook Katherine L. , Chen Chun , Shajahan-Haq Ayesha N. , Axelrod Margaret , Wärri Anni , Riggins Rebecca B. , Jin Lu , Haddad Bassem R. , Kallakury Bhaskar V. , Baumann William T. , Clarke Robert
Published: March 2023

Efficient knockdown of IRF1 using siRNA.
Supplementary Figure 5 from Interferon Regulatory Factor-1 Signaling Regulates the Switch between Autophagy and Apoptosis to Determine Breast Cancer Cell Fate
Authors: Schwartz-Roberts Jessica L. , Cook Katherine L. , Chen Chun , Shajahan-Haq Ayesha N. , Axelrod Margaret , Wärri Anni , Riggins Rebecca B. , Jin Lu , Haddad Bassem R. , Kallakury Bhaskar V. , Baumann William T. , Clarke Robert
Published: March 2023

dnIRF1 blocks ICI sensitivity in LCC1 cells.
Supplemental Table S2 from RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells
Authors: Ilmer Matthias , Boiles Alejandro Recio , Regel Ivonne , Yokoi Kenji , Michalski Christoph W. , Wistuba Ignacio I. , Rodriguez Jaime , Alt Eckhard , Vykoukal Jody
Published: March 2023

Supplemental Table S2. List of murine primer sequences used in qRT-PCR analysis in this study.
Supplemental Table S1 from RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells
Authors: Ilmer Matthias , Boiles Alejandro Recio , Regel Ivonne , Yokoi Kenji , Michalski Christoph W. , Wistuba Ignacio I. , Rodriguez Jaime , Alt Eckhard , Vykoukal Jody
Published: March 2023

Supplemental Table S1. Complete RPPA datasets for L3.6pl and Patx1.
Supplemental Figures S1-S8 from RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells
Authors: Ilmer Matthias , Boiles Alejandro Recio , Regel Ivonne , Yokoi Kenji , Michalski Christoph W. , Wistuba Ignacio I. , Rodriguez Jaime , Alt Eckhard , Vykoukal Jody
Published: March 2023

Supplemental Figures S1-S8. Heterogeneous activation of canonical Wnt in PDAC can be detected by lentiviral Tcf/LEF-Reporter (S1); Distinct biological properties in Wnt/GFPhigh vs. Wnt/GFPlow populations (S2); Certain Wnt/GFPhigh populations possess increased tumorigenic potential (S3); Gemcitabine enriches number of GFPhigh cells and GFPhigh cells display drug-resistance (S4); Evaluation of RSpo2 in TCGA datasets and IHC of tissue microarray (S5); Wnt/RSpo2 - high and low responders in PDAC /RSpo2 is a critical factor (S6); Downstream mechanisms of intrinsic and extrinsic Wnt activation in PDAC cells (S7); Graphical illustration of the proposed model. (S8).
Supplementary Figures 1 through 8 and Supplementary Tables 1 through 4 from Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT–YB1–MDR1 Signaling Pathway
Authors: Mo Dongliang , Fang Hongbo , Niu Kaifeng , Liu Jing , Wu Meng , Li Shiyou , Zhu Tienian , Aleskandarany Mohammed A. , Arora Arvind , Lobo Dileep N. , Madhusudan Srinivasan , Balajee Adayabalam S. , Chi Zhenfen , Zhao Yongliang
Published: March 2023

1. Supplementary Figure S1. PCR-SSCP analysis of 21 exons of human RecQL4 gene in human gastric cancer cell lines. 2. Supplementary Figure S2. PCR-SSCP analysis of 21 exons of human RecQL4 gene in human primary gastric tumors and matched gastric tissue controls. 3. Supplementary Figure S3. DNA sequencing result of exons 2-3 of human RecQL4 gene in AGS and HGC-27 cells. 4. Supplementary Figure S4. Coomassie brilliant blue staining images of purified tagged-proteins expressed in E. Coli. 5. Supplementary Figure S5. YB1 domains specifically interacting with RecQL4. 6. Supplementary Figure S6. Level of YB1 and Akt interaction in cytoplasmic(C) and nuclear (N) fractions from MGC-803/Tet-on/Flag-RecQL4 cells with or without RecQL4 induction. 7. Supplementary Figure S7. Effect of YB1 and RecQL4 on MVP promoter activity. 8. Supplementary Figure S8. In vitro direct binding of YB1 and/ RecQL4 proteins to MDR1 promoter region detected by EMSA analysis. 9. Supplementary Table S1. Clinicopathological characteristics of patients with early gastric adenocarcinomas. 10. Supplementary Table S2. Correlation of RecQL4 nuclear and cytoplasmic expression with clinical parameters of gastric cancer patients. 11. Supplementary Table S3. Primer sets of 21 exons of human RecQL4 gene used for PCR-SSCP analysis. 12. Supplementary Table S4. PCR primer sets of drug resistance related genes used for real time RT-PCR analysis.
Supplementary Figure S3 from CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity
Authors: Boyle Samantha E. , Fedele Clare G. , Corbin Vincent , Wybacz Elisha , Szeto Pacman , Lewin Jeremy , Young Richard J. , Wong Annie , Fuller Robert , Spillane John , Speakman David , Donahoe Simon , Pohl Miklos , Gyorki David , Henderson Michael A. , Johnstone Ricky W. , Papenfuss Anthony T. , Shackleton Mark
Published: March 2023

Typical sorting strategy used to isolate viable melanoma cells from cell suspensions derived by dissociation from patient tumors.
Supplementary information from Impact of Metabolic Heterogeneity on Tumor Growth, Invasion, and Treatment Outcomes
Authors: Robertson-Tessi Mark , Gillies Robert J. , Gatenby Robert A. , Anderson Alexander R.A.
Published: March 2023

Supplementary information. Derivations and supporting results
Supplementary Figure 3 from Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy
Authors: Maby Pauline , Tougeron David , Hamieh Mohamad , Mlecnik Bernhard , Kora Hafid , Bindea Gabriela , Angell Helen K. , Fredriksen Tessa , Elie Nicolas , Fauquembergue Emilie , Drouet Aurélie , Leprince Jérôme , Benichou Jacques , Mauillon Jacques , Le Pessot Florence , Sesboüé Richard , Tuech Jean-Jacques , Sabourin Jean-Christophe , Michel Pierre , Frébourg Thierry , Galon Jérôme , Latouche Jean-Baptiste
Published: March 2023

Supplementary Figure 3. In vitro cytotoxic activity of peripheral TLs from donors harboring or not mutations in TGFBR2, TAF1B and ASTE1 genes.
Supplementary Figure 1 from Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy
Authors: Maby Pauline , Tougeron David , Hamieh Mohamad , Mlecnik Bernhard , Kora Hafid , Bindea Gabriela , Angell Helen K. , Fredriksen Tessa , Elie Nicolas , Fauquembergue Emilie , Drouet Aurélie , Leprince Jérôme , Benichou Jacques , Mauillon Jacques , Le Pessot Florence , Sesboüé Richard , Tuech Jean-Jacques , Sabourin Jean-Christophe , Michel Pierre , Frébourg Thierry , Galon Jérôme , Latouche Jean-Baptiste
Published: March 2023

Correlation between CD3+ TIL densities calculated from whole slides and from TMA samples.
Supplementary Figure S1 from RAGE Mediates S100A7-Induced Breast Cancer Growth and Metastasis by Modulating the Tumor Microenvironment
Authors: Nasser Mohd W. , Wani Nissar Ahmad , Ahirwar Dinesh K. , Powell Catherine A. , Ravi Janani , Elbaz Mohamad , Zhao Helong , Padilla Laura , Zhang Xiaoli , Shilo Konstantin , Ostrowski Michael , Shapiro Charles , Carson William E. , Ganju Ramesh K.
Published: March 2023

RAGE/S100A7 axis inhibits breast cancer cell migration/invasion/motility.
Supplementary Table S1 from Adoptive Transfer of CD8+ T Cells Generated from Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along with Immunological Memory
Authors: Saito Hidehito , Okita Keisuke , Chang Alfred E. , Ito Fumito
Published: March 2023

Supplementary Table S1: Primers used in this study
Supplementary Materials and Methods from Adoptive Transfer of CD8+ T Cells Generated from Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along with Immunological Memory
Authors: Saito Hidehito , Okita Keisuke , Chang Alfred E. , Ito Fumito
Published: March 2023

Supplementary Materials and Methods
Supplemental figures 1-3 / Tables 1 and 2 from Urokinase Exerts Antimetastatic Effects by Dissociating Clusters of Circulating Tumor Cells
Authors: Choi Jin Woo , Kim Jun Ki , Yang Yun Jung , Kim Pilhan , Yoon Kwon-Ha , Yun Seok Hyun
Published: March 2023

Supplementary Figure 1. Specific infection of Telomescan Supplementary Figure 2. Validity of the number of CTCs in the peritumoral regions Supplementary Figure 3. Comparison of the tumorigenic and metastatic properties of GFP- and RFP-expressing 4T1 cells Supplementary Table 1. Isolated nodules categorized into 3 groups Supplementary Table 2. Mice injected with a mixture of GFP- and RFP-positive
Supplementary Figure 1 from Adoptive Transfer of CD8+ T Cells Generated from Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along with Immunological Memory
Authors: Saito Hidehito , Okita Keisuke , Chang Alfred E. , Ito Fumito
Published: March 2023

Phenotypic analysis of Pmel-1 splenocytes, thymocytes, ESCs (R1), and Pmel-1 iPSCs cultured on OP9 followed by OP9-DL1.
Supplemental Figure S5 from Targeted Deletion of p53 in Lgr5-Expressing Intestinal Stem Cells Promotes Colon Tumorigenesis in a Preclinical Model of Colitis-Associated Cancer
Authors: Davidson Laurie A. , Callaway Evelyn S. , Kim Eunjoo , Weeks Brad R. , Fan Yang-Yi , Allred Clinton D. , Chapkin Robert S.
Published: March 2023

Stem cell targeted p53 deletion does not affect tumor incidence following repeated cycles of AOM exposure.
Supplementary Table 1 from Tumor-Derived Osteopontin Reprograms Normal Mammary Fibroblasts to Promote Inflammation and Tumor Growth in Breast Cancer
Authors: Sharon Yoray , Raz Yael , Cohen Noam , Ben-Shmuel Amir , Schwartz Hila , Geiger Tamar , Erez Neta
Published: March 2023

Supplementary Table 1: Conditioned medium proteome. Intensity values (Log2 values) are indicated for each proteins with and without label-free quantification (LFQ) normalization. PEP- posterior error probability. 'Extracellular' column indicates the proteins annotated as such according Gene Ontology Cellular Compartment (GOCC).
Supplemental Figure S3 from A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor–Resistant Lung Tumors
Authors: Moores Sheri L. , Chiu Mark L. , Bushey Barbara S. , Chevalier Kristen , Luistro Leopoldo , Dorn Keri , Brezski Randall J. , Haytko Peter , Kelly Thomas , Wu Sheng-Jiun , Martin Pauline L. , Neijssen Joost , Parren Paul W.H.I. , Schuurman Janine , Attar Ricardo M. , Laquerre Sylvie , Lorenzi Matthew V. , Anderson G. Mark
Published: March 2023

Effect of Crizotinib on H1975 and H1975-HGF Xenograft Tumors
Supplementary Figure S2 from Acute Tissue Injury Activates Satellite Cells and Promotes Sarcoma Formation via the HGF/c-MET Signaling Pathway
Authors: Van Mater David , Añó Leonor , Blum Jordan M. , Webster Micah T. , Huang WeiQiao , Williams Nerissa , Ma Yan , Cardona Diana M. , Fan Chen-Ming , Kirsch David G.
Published: March 2023

Supplementary Figure S2. Intramuscular injection of HGF stimulates proliferation of Pax7+ cells in P7KP mice without causing tissue injury.
Supplementary Figure legends from HTLV-1 bZIP Factor RNA and Protein Impart Distinct Functions on T-cell Proliferation and Survival
Authors: Mitobe Yuichi , Yasunaga Jun-ichirou , Furuta Rie , Matsuoka Masao
Published: March 2023

Supplementary Figure legends
Supplementary table S1 from miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells
Authors: Zhang Jing , Jiao Jingjing , Cermelli Silvia , Muir Kyle , Jung Kwang Hwa , Zou Ruhai , Rashid Asif , Gagea Mihai , Zabludoff Sonya , Kalluri Raghu , Beretta Laura
Published: March 2023

Primers list
Supplementary Figure 3 from HTLV-1 bZIP Factor RNA and Protein Impart Distinct Functions on T-cell Proliferation and Survival
Authors: Mitobe Yuichi , Yasunaga Jun-ichirou , Furuta Rie , Matsuoka Masao
Published: March 2023

Upregulation of HBZ RNA target genes in Kit225-TTG
Figure S4 from Cell Cycle–Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells
Authors: Kothari Anisha , Hittelman Walter N. , Chambers Timothy C.
Published: March 2023

Supplementary Figure 4
Supplementary Table 1, Figures 1 - 9 from Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein
Authors: Kamphorst Jurre J. , Nofal Michel , Commisso Cosimo , Hackett Sean R. , Lu Wenyun , Grabocka Elda , Vander Heiden Matthew G. , Miller George , Drebin Jeffrey A. , Bar-Sagi Dafna , Thompson Craig B. , Rabinowitz Joshua D.
Published: March 2023

Table S1. Amino acid concentrations in pancreatic tumor and benign adjacent tissues Figure S1. Quantification of macropinocytosis in human pancreatic tumors. Figure S2. Few macropinosomes are present in the normal pancreatic tissue adjacent to PDAC tumors. Figure S3. Ras-mutant pancreatic cells are capable of indefinite growth in medium lacking leucine supplemented with physiological levels of serum protein. Figure S4. Ras-mutant pancreatic cells are capable of indefinite growth in medium lacking lysine or phenylalanine supplemented with physiological levels of serum protein. Figure S5. Growth of KRPC cells in leucine-free medium with 50 g/L serum protein cannot be explained by the presence of contaminating leucine. Figure S6. Stable isotope tracing reveals significant contribution of serum protein to amino acid pools in human PDAC cells. Figure S7. EIPA, an inhibitor of macropinocytosis, reduces intracellular (A) and extracellular (B) serum protein-derived amino acid pools in a dose-dependent fashion. Figure S8. Fractional contribution of serum protein-derived nitrogen to intracellular amino acid pools. Figure S9. Amino acid frequency in bovine serum albumin relative to human proteome.
Supp. Figure 6 from LIM Kinase Inhibitor Pyr1 Reduces the Growth and Metastatic Load of Breast Cancers
Authors: Prunier Chloé , Josserand Véronique , Vollaire Julien , Beerling Evelyne , Petropoulos Christos , Destaing Olivier , Montemagno Christopher , Hurbin Amandine , Prudent Renaud , de Koning Leanne , Kapur Reuben , Cohen Pascale A. , Albiges-Rizo Corinne , Coll Jean-Luc , van Rheenen Jacco , Billaud Marc , Lafanechère Laurence
Published: March 2023

Pyr1 effect on tumor cell density
Supp. Figure 4 from LIM Kinase Inhibitor Pyr1 Reduces the Growth and Metastatic Load of Breast Cancers
Authors: Prunier Chloé , Josserand Véronique , Vollaire Julien , Beerling Evelyne , Petropoulos Christos , Destaing Olivier , Montemagno Christopher , Hurbin Amandine , Prudent Renaud , de Koning Leanne , Kapur Reuben , Cohen Pascale A. , Albiges-Rizo Corinne , Coll Jean-Luc , van Rheenen Jacco , Billaud Marc , Lafanechère Laurence
Published: March 2023

Pharmacokinetic analysis of Pyr1 and its metabolite M1
Supplementary Methods, Figures S1-S12, Tables S1-S2 from Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC
Authors: Singleton Katherine R. , Hinz Trista K. , Kleczko Emily K. , Marek Lindsay A. , Kwak Jeff , Harp Taylor , Kim Jihye , Tan Aik Choon , Heasley Lynn E.
Published: March 2023

Supplementary Methods, Figures S1-S12, Tables S1-S2. Figure S1. Overview of workflow for the synthetic lethal and essential gene screens. Figure S2. Procedure for isolating and barcoding PCR-amplified shRNA sequences. Figure S3. Growth inhibition of H157 cells by ponatinib in combination with MTOR inhibitor, AZD8055. Figure S4. Relative sensitivity of cancer cell lines to MTOR inhibitor AZD8055 using a cell proliferation assay. Figure S5. Dose response curves for growth inhibition of cancer cell lines by rapamycin. Figure S6. Growth inhibition by FGFR inhibitors in combination with MTOR inhibitor, AZD8055. Figure S7. Synergistic growth inhibition of CCL30 HNSCC cells by AZD4547 and AZD8055. Figure S8. Growth inhibition of Colo699 and H1581 cells by AZD4547 and rapamycin. Figure S9. Signal pathway inhibition by FGFR TKIs and rapamycin alone, and in combination. Figure S10. Growth inhibition by AKT inhibitors alone and combined with ponatinib on Colo699 cells. Figure S11. Combination ponatinib and AKT inhibitor GSK690693 yields synergistic in vitro growth inhibition. Figure S12. Combination AZD4547 and AZD2014 provides superior growth inhibition of Colo699 xenografts. Table S1. Primers used for sample preparation for Illumina sequencing. Table S2. Ranking of Synthetic Lethal Hits with ponatinib Treatment.
Figure S4 from ERAP1 Regulates Natural Killer Cell Function by Controlling the Engagement of Inhibitory Receptors
Authors: Cifaldi Loredana , Romania Paolo , Falco Michela , Lorenzi Silvia , Meazza Raffaella , Petrini Stefania , Andreani Marco , Pende Daniela , Locatelli Franco , Fruci Doriana
Published: March 2023

Supplementary Figure S4 shows the gating strategy used to analyse degranulation of NK-cell subsets by flow cytometry
Supplemental Methods from Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer
Authors: Wang Miao , Topalovski Mary , Toombs Jason E. , Wright Christopher M. , Moore Zachary R. , Boothman David A. , Yanagisawa Hiromi , Wang Huamin , Witkiewicz Agnieszka , Castrillon Diego H. , Brekken Rolf A.
Published: March 2023

Description of additional methods and procedures used in the study.
Supplemental Figures S1-S7 from Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer
Authors: Wang Miao , Topalovski Mary , Toombs Jason E. , Wright Christopher M. , Moore Zachary R. , Boothman David A. , Yanagisawa Hiromi , Wang Huamin , Witkiewicz Agnieszka , Castrillon Diego H. , Brekken Rolf A.
Published: March 2023

Fbln5 and α5β1 integrin expression pattern in mouse and human (S1); Characterization of KIC and KPC mice (S2); Examination of ROS levels in normal pancreas and NAC-treated KIC and RGE KIC tumors (S3); Reduced microvessel density (MVD) in RGE KIC and RGE KPC tumors compared to KIC and KPC tumors (S4); Examination and quantification of MVD in pancreatic tissues from KIC and RGE KIC, WT and RGE mice (S5); Fbln5 expression in Fbln5 WT, KO and RGE MEFs (S6); NADPH oxidase (Nox) is not the source of ROS induction for RGE MEFs when plated on FN (S7).
Supplementary Tables 1-3 from Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface–Associated Calreticulin
Authors: Dudek-Perić Aleksandra M. , Ferreira Gabriela B. , Muchowicz Angelika , Wouters Jasper , Prada Nicole , Martin Shaun , Kiviluoto Santeri , Winiarska Magdalena , Boon Louis , Mathieu Chantal , van den Oord Joost , Stas Marguerite , Gougeon Marie-Lise , Golab Jakub , Garg Abhishek D. , Agostinis Patrizia
Published: March 2023

Supplementary Tables 1-3. Supplementary Table 1. Meta-data analysis of clinical response to melphalan-based isolated limbtreatment procedures in melanoma patients. Supplementary Table 2. Meta-data analysis of clinical response to melphalan/TNF or Mel/TNF/IFNγ combination therapies for isolated limb-treatment procedures in melanoma patients. Supplementary Table 3. Follow up information about the patients whose tumour samples were used for analysis of infiltration of immune cells and expression levels of cytokines.
Supplemental Figure 3 from Cell Division Patterns in Acute Myeloid Leukemia Stem-like Cells Determine Clinical Course: A Model to Predict Patient Survival
Authors: Stiehl Thomas , Baran Natalia , Ho Anthony D. , Marciniak-Czochra Anna
Published: March 2023

Supplemental Figure 3. The figure compares estimated LSC properties in first and second relapse of 4 patients.
Supplementary Figures 1-6 from Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface–Associated Calreticulin
Authors: Dudek-Perić Aleksandra M. , Ferreira Gabriela B. , Muchowicz Angelika , Wouters Jasper , Prada Nicole , Martin Shaun , Kiviluoto Santeri , Winiarska Magdalena , Boon Louis , Mathieu Chantal , van den Oord Joost , Stas Marguerite , Gougeon Marie-Lise , Golab Jakub , Garg Abhishek D. , Agostinis Patrizia
Published: March 2023

Supplementary Figures 1-6. Suppl. Fig. 1. Mel-ILP induces release of certain cytokines, however does not affect infiltration of immune cells into tumor bed. Suppl. Fig. 2. Melphalan induces apoptosis of melanoma cells. Suppl. Fig. 3 Melphalan induces exposure of danger signals. Suppl. Fig. 4. Dying human melanoma cells induce danger signaling-independent in vitro stimulation of immune cells. Suppl. Fig. 5. In vitro treated melanoma cells do not strongly activate NK cells. Suppl. Fig. 6. (A) The phenotypic maturation of murine iDCs (B) Effect of antibodybased elimination of CD4+ and CD8+ cells in prophylactic mice vaccination experiment
Supplementary Tables S1-3 from miR340 Suppresses the Stem-like Cell Function of Glioma-Initiating Cells by Targeting Tissue Plasminogen Activator
Authors: Yamashita Daisuke , Kondo Toru , Ohue Shiro , Takahashi Hisaaki , Ishikawa Madoka , Matoba Ryo , Suehiro Satoshi , Kohno Shohei , Harada Hironobu , Tanaka Junya , Ohnishi Takanori
Published: March 2023

Supplementary Table S1-3 Supplementary Table S1. Primers used for RT-PCR Supplementary Table S2. Primers used for amplification of full-length human plat gene Supplementary Table S3. Primers used to generate plat 3'UTR reporter constructs
Supplementary Tables S1-S5 from Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations
Authors: Dogruluk Turgut , Tsang Yiu Huen , Espitia Maribel , Chen Fengju , Chen Tenghui , Chong Zechen , Appadurai Vivek , Dogruluk Armel , Eterovic Agna Karina , Bonnen Penelope E. , Creighton Chad J. , Chen Ken , Mills Gordon B. , Scott Kenneth L.
Published: March 2023

PIK3CA mutations in breast cancer from the COSMIC database (S1); Predictions by computational algorithms on the consequences of PIK3CA missense mutations (S2); Mutagenic primer and barcode sequences of PIK3CA constructs and HiTMMoB reaction efficiencies (S3); Representative phenotyping for PIK3CA variants (S4); Barcode representation for PIK3CA variants in each sequenced tumor core (S5).
Supplementary Table S1 from Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2-Triggered Drug Resistance
Authors: Krumm Andrea , Barckhausen Christina , Kücük Pelin , Tomaszowski Karl-Heinz , Loquai Carmen , Fahrer Jörg , Krämer Oliver Holger , Kaina Bernd , Roos Wynand Paul
Published: March 2023

Antibodies used for immunohistochemistry, Western blot analysis and immunofluorescence.
Supplementary Figure S4 from Diverse Targets of β-Catenin during the Epithelial–Mesenchymal Transition Define Cancer Stem Cells and Predict Disease Relapse
Authors: Chang Yi-Wen , Su Ying-Jhen , Hsiao Michael , Wei Kuo-Chen , Lin Wei-Hsin , Liang Chi-Jung , Chen Shin-Cheh , Lee Jia-Lin
Published: March 2023

Supplementary Figure S4: The results of ChIP-seq analysis were further validated by SP percentage assays.
Supplementary Table S5 from The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis
Authors: Riesco-Eizaguirre Garcilaso , Wert-Lamas León , Perales-Patón Javier , Sastre-Perona Ana , Fernández Lara P. , Santisteban Pilar
Published: March 2023

The most abundant deregulated miRs targeting the main genes essential for thyroid differentiation.
Supplementary Dataset S4 from The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis
Authors: Riesco-Eizaguirre Garcilaso , Wert-Lamas León , Perales-Patón Javier , Sastre-Perona Ana , Fernández Lara P. , Santisteban Pilar
Published: March 2023

Putative PAX8 binding regions upstream the transcription start site of both human and rat miR-146b.
Supplemental Methods from A Modeling Approach to Explain Mutually Exclusive and Co-Occurring Genetic Alterations in Bladder Tumorigenesis
Authors: Remy Elisabeth , Rebouissou Sandra , Chaouiya Claudine , Zinovyev Andrei , Radvanyi François , Calzone Laurence
Published: March 2023

Supplemental Methods. Description of the model and its properties; Table S1. Logical rules; Table S2. Model attractors for the wild type case; Table S3. Model coherence with published data; and Table S4. Model predictions
Supplementary Video S1 from Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis
Authors: Schaub Franz X. , Reza Md. Shamim , Flaveny Colin A. , Li Weimin , Musicant Adele M. , Hoxha Sany , Guo Min , Cleveland John L. , Amelio Antonio L.
Published: March 2023

Living Image DLIT 3D reconstruction of A549-GpNLuc orthotopic xenograft transplant.
Supplementary Figures S1-S9 from Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis
Authors: Schaub Franz X. , Reza Md. Shamim , Flaveny Colin A. , Li Weimin , Musicant Adele M. , Hoxha Sany , Guo Min , Cleveland John L. , Amelio Antonio L.
Published: March 2023

Supplementary Figures S1-S9. Figure S1. Functional evaluation of the GpNLuc LumiFluor. Figure S2. In vitro characterization of FACS sorted mouse Em-Myc lymphoma and human non-small cell lung cancer (NSCLC) cells. Figure S3. Temporal development of A549 NSCLC xenograft tumors expressing GpNLuc or GpNLuc and the tumor suppressor LKB1. Figure S4. Detection of spontaneous lymph node metastasis from primary lung tumors. Figure S5. In vitro and in vivo characterization of independently derived E?-Myc lymphoma cells stably expressing GpNLuc. Figure S6. Bioluminescence imaging of E?-Myc lymphoma-GpNLuc allografts. Figure S7. A, in vivo dose-response kinetics of GpNLuc signal strength. Figure S8. Quantification of in vivo bioluminescence imaging and confirmation ex vivo. Figure S9. Flow cytometric analysis of inducibly expressed fluorescent proteins in stable lymphoma cell lines.
Revised Supplementary Information from Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis
Authors: Schaub Franz X. , Reza Md. Shamim , Flaveny Colin A. , Li Weimin , Musicant Adele M. , Hoxha Sany , Guo Min , Cleveland John L. , Amelio Antonio L.
Published: March 2023

Revised Supplementary Materials and Methods and Supplementary Figure Legends
Supplementary Fig. S2 from Combining miR-10b–Targeted Nanotherapy with Low-Dose Doxorubicin Elicits Durable Regressions of Metastatic Breast Cancer
Authors: Yoo Byunghee , Kavishwar Amol , Ross Alana , Wang Ping , Tabassum Doris P. , Polyak Kornelia , Barteneva Natalia , Petkova Victoria , Pantazopoulos Pamela , Tena Aseda , Moore Anna , Medarova Zdravka
Published: March 2023

Supplementary Fig. S2. Nuclear and cytoskeletal reorganization by the treatment in metastatic breast cancer cells.
Supplemental Figure S2 - from The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma
Authors: Harms Paul William , Vats Pankaj , Verhaegen Monique Elise , Robinson Dan R. , Wu Yi-Mi , Dhanasekaran Saravana Mohan , Palanisamy Nallasivam , Siddiqui Javed , Cao Xuhong , Su Fengyun , Wang Rui , Xiao Hong , Kunju Lakshmi P. , Mehra Rohit , Tomlins Scott A. , Fullen Douglas Randall , Bichakjian Christopher Keram , Johnson Timothy M. , Dlugosz Andrzej Antoni , Chinnaiyan Arul M.
Published: March 2023

Supplemental Figure S2. Mutational signatures of Merkel cell polyomavirus-positive Merkel cell carcinomas
Supplemental Figure S4 from A Urokinase Receptor–Bim Signaling Axis Emerges during EGFR Inhibitor Resistance in Mutant EGFR Glioblastoma
Authors: Wykosky Jill , Hu Jingjing , Gomez German G. , Taylor Tiffany , Villa Genaro R. , Pizzo Donald , VandenBerg Scott R. , Thorne Amy Haseley , Chen Clark C. , Mischel Paul S. , Gonias Steven L. , Cavenee Webster K. , Furnari Frank B.
Published: March 2023

Supplemental Figure S4. Suppression of cell death inresistant clones
Supplemental Figure S2 from A Urokinase Receptor–Bim Signaling Axis Emerges during EGFR Inhibitor Resistance in Mutant EGFR Glioblastoma
Authors: Wykosky Jill , Hu Jingjing , Gomez German G. , Taylor Tiffany , Villa Genaro R. , Pizzo Donald , VandenBerg Scott R. , Thorne Amy Haseley , Chen Clark C. , Mischel Paul S. , Gonias Steven L. , Cavenee Webster K. , Furnari Frank B.
Published: March 2023

Supplemental Figure S2. Viability assay of resistant cell lines
Supplementary Figure S5 from PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis
Authors: Green Shon , Trejo Christy L. , McMahon Martin
Published: March 2023

Orthotopic lung tumorigenesis following injection of tumor derived cell lines of defined Kras or Pik3ca genotype.
Figure S1 from Interleukin-5 Facilitates Lung Metastasis by Modulating the Immune Microenvironment
Authors: Zaynagetdinov Rinat , Sherrill Taylor P. , Gleaves Linda A. , McLoed Allyson G. , Saxon Jamie A. , Habermann Arun C. , Connelly Linda , Dulek Daniel , Peebles R. Stokes , Fingleton Barbara , Yull Fiona E. , Stathopoulos Georgios T. , Blackwell Timothy S.
Published: March 2023

Figure S1. Lung eosinophils (Eos), identified as CD45+/CD11c-/ F4/80+/siglec-F+ cells using flow cytometry are A) negative for CD68, B) express high levels of CCR3, and C) express low levels of Gr1 compared to the CD45+/Gr1hi neutrophils (PMN).
Supplementary Figure S1 from PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis
Authors: Green Shon , Trejo Christy L. , McMahon Martin
Published: March 2023

Comparison of ERK1/2 and AKT activation in KRASG12D- versus KRASG12D/PIK3CAH1047R-driven lung tumors.
Supplementary Figure S2 from Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations
Authors: Emir Uzay E. , Larkin Sarah J. , de Pennington Nick , Voets Natalie , Plaha Puneet , Stacey Richard , Al-Qahtani Khalid , Mccullagh James , Schofield Christopher J. , Clare Stuart , Jezzard Peter , Cadoux-Hudson Tom , Ansorge Olaf
Published: March 2023

Amplitudes of 2-hydroxyglutarate (2-HG) signal for density matrix simulation of pulse acquire and semi-LASER at TE = 110 ms (TE1 =11 ms, TE2 = 65 ms and TE3 = 34 ms) acquisitions.
Supplemental Figure S2 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Authors: Zhu Jieqing , Xiong Gaofeng , Fu Hanjiang , Evers B. Mark , Zhou Binhua P. , Xu Ren
Published: March 2023

Supplemental Figure S2. MiR-29 is a potential regulator of multiple ECM network genes.
Supplemental Figure S1 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Authors: Zhu Jieqing , Xiong Gaofeng , Fu Hanjiang , Evers B. Mark , Zhou Binhua P. , Xu Ren
Published: March 2023

Supplemental Figure S1. Hsp47 expression is upregulated in various cancers, but the upregulation is not sufficient to induce transformation.
Supplemetary Video S7 from Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Authors: Stanisavljevic Jelena , Loubat-Casanovas Jordina , Herrera Mercedes , Luque Tomás , Peña Raúl , Lluch Ana , Albanell Joan , Bonilla Félix , Rovira Ana , Peña Cristina , Navajas Daniel , Rojo Federico , García de Herreros Antonio , Baulida Josep
Published: March 2023

Video S7. Ela-Myc cells on 3D-ECM generated by KO MEFs.
Supplemetary Video S6 from Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Authors: Stanisavljevic Jelena , Loubat-Casanovas Jordina , Herrera Mercedes , Luque Tomás , Peña Raúl , Lluch Ana , Albanell Joan , Bonilla Félix , Rovira Ana , Peña Cristina , Navajas Daniel , Rojo Federico , García de Herreros Antonio , Baulida Josep
Published: March 2023

Video S6. Ela-Myc cells on 3D-ECM generated by TGFÃŽÂ²-treated Control MEFs.
Supplementary Data Figure Legends from CD38 in Hairy Cell Leukemia Is a Marker of Poor Prognosis and a New Target for Therapy
Authors: Poret Nicolas , Fu Qiangwei , Guihard Soizic , Cheok Meyling , Miller Katie , Zeng Gordon , Quesnel Bruno , Troussard Xavier , Galiègue-Zouitina Sylvie , Shelley Carl Simon
Published: March 2023

Supplementary Data Legends to Figures 1-4
Supplemetary Video S1 from Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Authors: Stanisavljevic Jelena , Loubat-Casanovas Jordina , Herrera Mercedes , Luque Tomás , Peña Raúl , Lluch Ana , Albanell Joan , Bonilla Félix , Rovira Ana , Peña Cristina , Navajas Daniel , Rojo Federico , García de Herreros Antonio , Baulida Josep
Published: March 2023

Video S1. MDA-MB231 cells on 3D-ECM generated by Control MEFs.
Supplemental Figure S3 from PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment
Authors: Li Jing , Jie Hyun-Bae , Lei Yu , Gildener-Leapman Neil , Trivedi Sumita , Green Tony , Kane Lawrence P. , Ferris Robert L.
Published: March 2023

Supplemental Figure S3. Fusaruside triggers the tyrosine phosphorylation of SHP-2 in human T lymphocytes from PBMC.
Supplementary Table S1 from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
Authors: Hughes Russell , Qian Bin-Zhi , Rowan Charlotte , Muthana Munitta , Keklikoglou Ioanna , Olson Oakley C. , Tazzyman Simon , Danson Sarah , Addison Christina , Clemons Mark , Gonzalez-Angulo Ana Maria , Joyce Johanna A. , De Palma Michele , Pollard Jeffrey W. , Lewis Claire E.
Published: March 2023

Antibody Details
Supplementary Figure 3 from Genetic Mutation of p53 and Suppression of the miR-17∼92 Cluster Are Synthetic Lethal in Non–Small Cell Lung Cancer due to Upregulation of Vitamin D Signaling
Authors: Borkowski Robert , Du Liqin , Zhao Zhenze , McMillan Elizabeth , Kosti Adam , Yang Chin-Rang , Suraokar Milind , Wistuba Ignacio I. , Gazdar Adi F. , Minna John D. , White Michael A. , Pertsemlidis Alexander
Published: March 2023

Supplementary Figure 3. Transcriptional profiling of HBEC30KT and HBEC30KT-shTP53 identifies context-dependent de-repression of the miR-17~92 targetome after p53 loss driven by target genes of the miR-17-92 polycistron.
Supplementary Figure Legends from Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis
Authors: Yuzefovych Larysa V. , Kahn Andrea G. , Schuler Michele A. , Eide Lars , Arora Ritu , Wilson Glenn L. , Tan Ming , Rachek Lyudmila I.
Published: March 2023

Legend for Supplementary Figures S1-S4.
Supplemental Figure 7 from Tumor Radiosensitization by Monomethyl Auristatin E: Mechanism of Action and Targeted Delivery
Authors: Buckel Lisa , Savariar Elamprakash N. , Crisp Jessica L. , Jones Karra A. , Hicks Angel M. , Scanderbeg Daniel J. , Nguyen Quyen T. , Sicklick Jason K. , Lowy Andrew M. , Tsien Roger Y. , Advani Sunil J.
Published: March 2023

Schematic model of therapeutic strategy utilizing tumor targeted MMAE delivery with ACPP.
Supplemental Figure 2 from BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells
Authors: Alford Sarah E. , Kothari Anisha , Loeff Floris C. , Eichhorn Joshua M. , Sakurikar Nandini , Goselink Henriette M. , Saylors Robert L. , Jedema Inge , Falkenburg J.H. Frederik , Chambers Timothy C.
Published: March 2023

Supplemental Figure 2: Primary ALL cells are highly sensitive to ABT-199.
Supplemental Table 1 from Spatially Resolved Metabolic Phenotyping of Breast Cancer by Desorption Electrospray Ionization Mass Spectrometry
Authors: Guenther Sabine , Muirhead Laura J. , Speller Abigail V.M. , Golf Ottmar , Strittmatter Nicole , Ramakrishnan Rathi , Goldin Robert D. , Jones Emrys , Veselkov Kirill , Nicholson Jeremy , Darzi Ara , Takats Zoltan
Published: March 2023

Supplemental Table 1. Number of patients and samples per group and model.
Supplementary Figure Legends from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
Authors: Hunter Francis W. , Young Richard J. , Shalev Zvi , Vellanki Ravi N. , Wang Jingli , Gu Yongchuan , Joshi Naveen , Sreebhavan Sreevalsan , Weinreb Ilan , Goldstein David P. , Moffat Jason , Ketela Troy , Brown Kevin R. , Koritzinsky Marianne , Solomon Benjamin , Rischin Danny , Wilson William R. , Wouters Bradly G.
Published: March 2023

Supplementary Figure Legends from Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs
Supplemental Figure S4 from Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer
Authors: Neskey David M. , Osman Abdullah A. , Ow Thomas J. , Katsonis Panagiotis , McDonald Thomas , Hicks Stephanie C. , Hsu Teng-Kuei , Pickering Curtis R. , Ward Alexandra , Patel Ameeta , Yordy John S. , Skinner Heath D. , Giri Uma , Sano Daisuke , Story Michael D. , Beadle Beth M. , El-Naggar Adel K. , Kies Merrill S. , William William N. , Caulin Carlos , Frederick Mitchell , Kimmel Marek , Myers Jeffrey N. , Lichtarge Olivier
Published: March 2023

Supplemental Figure S4. Comparison of disruptive and truncating p53 classification systems in the validation set.
Supplemental Figure S1 from Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer
Authors: Neskey David M. , Osman Abdullah A. , Ow Thomas J. , Katsonis Panagiotis , McDonald Thomas , Hicks Stephanie C. , Hsu Teng-Kuei , Pickering Curtis R. , Ward Alexandra , Patel Ameeta , Yordy John S. , Skinner Heath D. , Giri Uma , Sano Daisuke , Story Michael D. , Beadle Beth M. , El-Naggar Adel K. , Kies Merrill S. , William William N. , Caulin Carlos , Frederick Mitchell , Kimmel Marek , Myers Jeffrey N. , Lichtarge Olivier
Published: March 2023

Supplemental Figure S1. The mutational status of the TP53 constructs.
Supplemental Figure Legends from Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer
Authors: Neskey David M. , Osman Abdullah A. , Ow Thomas J. , Katsonis Panagiotis , McDonald Thomas , Hicks Stephanie C. , Hsu Teng-Kuei , Pickering Curtis R. , Ward Alexandra , Patel Ameeta , Yordy John S. , Skinner Heath D. , Giri Uma , Sano Daisuke , Story Michael D. , Beadle Beth M. , El-Naggar Adel K. , Kies Merrill S. , William William N. , Caulin Carlos , Frederick Mitchell , Kimmel Marek , Myers Jeffrey N. , Lichtarge Olivier
Published: March 2023

Legends for Supplemental Figures S1-S4.
Supplementary Figure Legend from Checkpoint Kinase 2 Negatively Regulates Androgen Sensitivity and Prostate Cancer Cell Growth
Authors: Ta Huy Q. , Ivey Melissa L. , Frierson Henry F. , Conaway Mark R. , Dziegielewski Jaroslaw , Larner James M. , Gioeli Daniel
Published: March 2023

Legend for Supplementary Figure S1.
Supplementary Figure S3 from β-Catenin Promotes Regulatory T-cell Responses in Tumors by Inducing Vitamin A Metabolism in Dendritic Cells
Authors: Hong Yuan , Manoharan Indumathi , Suryawanshi Amol , Majumdar Tanmay , Angus-Hill Melinda L. , Koni Pandelakis A. , Manicassamy Balaji , Mellor Andrew L. , Munn David H. , Manicassamy Santhakumar
Published: March 2023

Supplementary Figure S3. β-catenin signaling in DCs limits antitumor immunity by regulating the expression of co-inhibitory and co-stimulatory molecules.
Supplementary Figure 3 from PI3K–mTORC2 but not PI3K–mTORC1 Regulates Transcription of HIF2A/EPAS1 and Vascularization in Neuroblastoma
Authors: Mohlin Sofie , Hamidian Arash , von Stedingk Kristoffer , Bridges Esther , Wigerup Caroline , Bexell Daniel , Påhlman Sven
Published: March 2023

Supplementary Figure 3. Knockdown or chemical inhibition of Akt does not affect HIF2A expression.
Supplementary Figure 4 from Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rγnull Immunodeficient Mice
Authors: Sanmamed Miguel F. , Rodriguez Inmaculada , Schalper Kurt A. , Oñate Carmen , Azpilikueta Arantza , Rodriguez-Ruiz Maria E. , Morales-Kastresana Aizea , Labiano Sara , Pérez-Gracia Jose L. , Martín-Algarra Salvador , Alfaro Carlos , Mazzolini Guillermo , Sarno Francesca , Hidalgo Manuel , Korman Alan J. , Jure-Kunkel Maria , Melero Ignacio
Published: March 2023

hCD137 and hPD1 expression in human T-lymphocytes infiltrating spleen and liver.
Supplementary Figure 6 from Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer
Authors: Lanzardo Stefania , Conti Laura , Rooke Ronald , Ruiu Roberto , Accart Nathalie , Bolli Elisabetta , Arigoni Maddalena , Macagno Marco , Barrera Giuseppina , Pizzimenti Stefania , Aurisicchio Luigi , Calogero Raffaele Adolfo , Cavallo Federica
Published: March 2023

Evaluation of efficacy of anti-xCT vaccination on TUBO or 4T1 derived lung metastases
supplementary Figures S1-S10 from Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer
Authors: Pettazzoni Piergiorgio , Viale Andrea , Shah Parantu , Carugo Alessandro , Ying Haoqiang , Wang Huamin , Genovese Giannicola , Seth Sahil , Minelli Rosalba , Green Tessa , Huang-Hobbs Emmet , Corti Denise , Sanchez Nora , Nezi Luigi , Marchesini Matteo , Kapoor Avnish , Yao Wantong , Francesco Maria E. Di , Petrocchi Alessia , Deem Angela K. , Scott Kenneth , Colla Simona , Mills Gordon B. , Fleming Jason B. , Heffernan Timothy P. , Jones Philip , Toniatti Carlo , DePinho Ronald A. , Draetta Giulio F.
Published: March 2023

supplementary Figures S1-S10. S1 growth and regression of iKRAS tumors. S2 culture comparison. S3 immunohistochemistry of p-erk and p-s6 S4 Phospho rtk array S5 Validation of anti AXL antibodies S6 validationn of the AXL inhibitor in vitro S7 validationn of the AXL inhibitor in vivo S8 efficacy of targeting AXL S9 RTK array of iKRAS cells treated with multiple RTK inhibitors S10 P-ERK levels
Supplementary Materials and Methods from Targeting LUNX Inhibits Non–Small Cell Lung Cancer Growth and Metastasis
Authors: Zheng Xiaohu , Cheng Min , Fu Binqing , Fan Xiaolei , Wang Qing , Yu Xiaoqing , Sun Rui , Tian Zhigang , Wei Haiming
Published: March 2023

Supplementary Materials and Methods
Supplementary Figure S5 from IL10 and PD-1 Cooperate to Limit the Activity of Tumor-Specific CD8+ T Cells
Authors: Sun Zhaojun , Fourcade Julien , Pagliano Ornella , Chauvin Joe-Marc , Sander Cindy , Kirkwood John M. , Zarour Hassane M.
Published: March 2023

Supplementary Figure S5. IL-10R blockade adds to PD-1 blockade to increase the expansion and functions of NY-ESO-1-specific CD8+ T cells.
Supplemental Figure S2 from Obesity Contributes to Ovarian Cancer Metastatic Success through Increased Lipogenesis, Enhanced Vascularity, and Decreased Infiltration of M1 Macrophages
Authors: Liu Yueying , Metzinger Matthew N. , Lewellen Kyle A. , Cripps Stephanie N. , Carey Kyle D. , Harper Elizabeth I. , Shi Zonggao , Tarwater Laura , Grisoli Annie , Lee Eric , Slusarz Ania , Yang Jing , Loughran Elizabeth A. , Conley Kaitlyn , Johnson Jeff J. , Klymenko Yuliya , Bruney Lana , Liang Zhong , Dovichi Norman J. , Cheatham Bentley , Leevy W. Matthew , Stack M. Sharon
Published: March 2023

Representative histology of Cohort 2 metastatic implants in control or DIO C57/Bl6 mice.
Supplementary Figure S2 from IL10 and PD-1 Cooperate to Limit the Activity of Tumor-Specific CD8+ T Cells
Authors: Sun Zhaojun , Fourcade Julien , Pagliano Ornella , Chauvin Joe-Marc , Sander Cindy , Kirkwood John M. , Zarour Hassane M.
Published: March 2023

Supplementary Figure S2. IL-10 is produced by multiple cell subsets in PBMCs of melanoma patients.
Supplementary Figure S1 from IL10 and PD-1 Cooperate to Limit the Activity of Tumor-Specific CD8+ T Cells
Authors: Sun Zhaojun , Fourcade Julien , Pagliano Ornella , Chauvin Joe-Marc , Sander Cindy , Kirkwood John M. , Zarour Hassane M.
Published: March 2023

Supplementary Figure S1. IL-10R is expressed by multiple cell subsets in PBMCs of melanoma patients.