bluuebunny/crossref_metadata_2025 huggingface dataset:
PENENTUAN POTENSI TAMBAK BANDENG DI KABUPATEN SIDOARJO MENGGUNAKAN ANALYTICAL HIERRARCHY PROCESS
Authors: Mutmainah Dini Nafisatul , Slamet Ahmad Haris Hasanuddin , Dhandy Rahmat , Wulandari Sekar Ayu , Brillyantina Septine , Asmunir Asmunir , Kusumaningrum Kirana
Published: December 2023

Penelitian ini menggunakan metode Analytical Hierrarchy Process (AHP) dan untuk mengevaluasi berbagai alternatif berdasarkan kriteria yang berbeda, memberikan skor relatif untuk setiap alternatif dibeberapa lokasi tambak bandeng di Kabupaten Sidoarjo, serta membuat keputusan multi-kriteria dalam menentukan potensi tambak bandeng di Kabupaten Sidoarjo. Hasil analisis diperoleh faktor fisik yaitu nilai temperatur EVN 0,301, nilai salinitas 0,699. Faktor kimia yaitu nilai pH EVN 0,101, nilai DO EVN 0,213, nilai Nitrat EVN 0,331 dan nilai fosfat EVN 0,356.
PERTUMBUHAN RUMPUT GAJAH MINI (Pennisetum purpurem cv. Mott) DENGAN PEMBERIAN PUPUK ORGANIK CAIR (URINE DOMBA)
Authors: Syukran Muhammad , Risna Yayuk Kurnia , Fadli Chairul , Adam Koji Al , Zubaidah Sitti
Published: December 2023

Pertumbuhan rumput dipengaruhi oleh kesuburan tanah. Meningkatkan kesuburan tanah dapat dilakukan dengan memberi pupuk pada tanah. Langkah ini dapat dilakukan dengan penggunaan pupuk organik cair (POC) sebagai sumber utamanya yaitu urine domba. Penelitian dilakukan di Desa Coat Ara Kecamatan Kutablang Kabupaten Bireuen-Aceh. Penelitian ini menggunakan Rancangan Acak Kelompok non Faktorial dengan empat perlakuan dan empat ulangan sebagai kelompok. Perlakuan A: Kontrol (tanpa pemberian pupuk); Perlakuan B: POC 50 ml/perlakuan; Perlakuan C: POC 100 ml/perlakuan; Perlakuan D: POC 150 ml/perlakuan. Parameter yang diamati adalah jumlah anakan, jumlah daun, tinggi tanaman dan produksi rumput gajah mini. Hasil penelitian diperoleh bahwa pemberian POC dengan level berbeda dapat mempertahankan jumlah anakan, dan dapat meningkatkan jumlah daun, tinggi tanaman dan produksi rumput gajah mini. Pemberian dengan jumlah terbaik pupuk organik cair terdapat pada perlakuan D (150 ml/perlakuan).
Automatic Transfer Switch Kontrol Menggunakan Internet Of Thing (IoT)
Authors: RAHMAN M. FADHILUR
Published: December 2023

This research aims to develop and implement an Automatic Transfer Switch (ATS) control system using the Internet of Things (IoT) within the Nurul Jadid University environment. ATS is an important device in an electrical distribution system that allows automation of switching between primary and backup electrical power sources in fault situations. By utilizing IoT technology, this research aims to improve the efficiency, performance and monitoring of ATS at Nurul Jadid University, The research methodology involves designing, manufacturing, and testing a prototype of an IoT-based ATS system. Smart sensors will be installed on ATS devices to monitor parameters such as voltage, current, temperature and device status. Data collected by sensors will be sent via the IoT network to a monitoring platform that can be accessed in real-time by operators and maintenance personnel. It is hoped that the results of this research will increase the availability and reliability of electricity supply at Nurul Jadid University, by enabling early detection and quick action in disturbance situations. In addition, this system will also help optimize the use of electrical resources and reduce unnecessary energy consumption.

 By combining IoT technology with ATS control, this research presents an innovative solution to increase the efficiency and reliability of electricity supply in university environments. The results of this research can be a guide for other institutions interested in adopting similar technology in their electricity resource management
Komunikasi Digital E-commerce bagi Masyarakat Perdesaan
Authors: Haris Abdul , Marlina Marlina
Published: December 2023

Belanja lewat online saat ini bukan hal aneh, karena perkembangan dunia digital yang pesat telah mengantarkan kita kepada situasi serba praktis dan cepat. Dukungan internet sebagai alat yang menghubungkan media digital digunakan tidak saja untuk mencari informasi tetapi juga digunakan untuk berbagai keperluan. Perkembangan teknologi ini telah memberikan kemudahan bagi segala aspek kehidupan, salah satunya kemudahan berbisnis melalui sarana internet atau e-commerce. Pemasaran pada dunia digital dengan menggunakan software marketing automation sudah bisa digunakan sebagai sarana yang efektif untuk mempromosikan produk dan bisnis e-commerce. Tidak begitu sulit jika ingin mendapatkan aplikasi maupun informasi bagaimana cara memasarkan produk dan jasa e-commerce tersebut melalui dunia digital. Perkembangan digital tidak saja di perkotaan akan tetapi sudah sampai ke perdesaan. Dengan menggunakan metode kualitatif melalui pendekatan deskriptif penelitian ini bertujuan untuk mengetahui perkembangan e-commerce. Beberapa komoditas yang potensial memasuki pasar ekspor sangat membutuhkan pengetahuan dan teknologi digital. Pemasaran kopi arabika dari Aceh Gayo, misalnya, dapat menjadi contoh ketika para pengusaha kopi arabika ingin mendapatkan pembeli potensial dari luar negeri. Para pedagang kopi lokal menggunakan teknologi internet dan komunikasi digital secara otodidak sehingga dapat memasarkan kopi mereka ke para pengusaha di Medan hingga ke manca negara. Komunikasi digital telah mengantarkan masyarakat desa membangun entrepreneurship dalam berbisnis.
The Time Politics of Refugee Resettlement and Higher Education in the United States
Authors: Wolfgram Matthew , Van Auken Paul
Published: December 2023

This paper sheds light on experiences within systems of US resettlement and its structures of (un)welcome. There is considerable evidence that the policy framework of these systems complicates the possibilities of higher education for refugees. Drawing on interviews with residents with a refugee background and resettlement service providers, we explore how US refugee resettlement policy creates obstacles for refugees in pursuing higher education and professional work by imposing a particular regimentation of time on refugees’ lives that impels them to rapidly integrate into low-income employment markets. We argue that such a time politics of speed hastens the resettlement process to advance the goal that residents with refugee background obtain rapid economic self-sufficiency and discuss the policy implications.
The head of Defense of the Okhotsk district of the Siberian Volunteer Squad is Captain Boris Mikhailovich Mikhailovsky
Authors: Runev Andrei Olegovich
Published: December 2023

The article is devoted to the military biography of the participant of the First World War, the civil war in Siberia, the governor of the Tomsk province during the reign of Alexander Vasilyevich Kolchak, the organizer of the Yakut campaign and the chief of defense of the Okhotsk district of the Siberian Volunteer squad, Captain Boris Mikhailovich Mikhailovsky, whose biography is currently incomplete and focuses on the events when B. M. Mikhailovsky held the position of manager The province. Meanwhile, all that is known about B. M. Mikhailovsky as the chief of defense of the Okhotsk district of the Siberian Volunteer squad is that he disobeyed the order of the commander of the squad A. N. Pepelyaev on the transfer of civil power to representatives in Okhotsk and usurped power in the Okhotsk region. The work was carried out in compliance with the basic scientific principles of objectivity, historicism and multifactoriality. Within the framework of the problems of intellectual history, it is considered justified to apply an approach based on microhistoric analysis. The author pays special attention to the period of Mikhailovsky's participation in the organization and implementation of Lieutenant General Pepelyaev's campaign in Yakutia, as a poorly illuminated area in the biography of a white officer. Documents from the National Archive of the Republic of Sakha (Yakutia) are introduced into scientific circulation, which contain orders, proclamations, letters from participants in the events of 1922-1923. Special attention is paid to the situation of the city of Okhotsk during the civil war in Yakutia, the cold confrontation between Mikhailovsky, as a representative of the Siberian Volunteer Squad and the Provisional Yakut Regional People's Government. The author concludes that Captain Mikhailovsky was not the last officer in the Civil War and the Yakut campaign, and played an important role in the events under consideration. This work is important for a comprehensive and objective coverage of the events of the civil war in Russia, filling in the white spots in the biography of Mikhailovsky, who is widely known as the governor of the Tomsk province during the Kolchak government, but remains unknown during the years of the campaign of the squad in Yakutia, one of the organizers of which he was. In addition, this work allows you to get to know Lieutenant General Pepelyaev's entourage better through studying his associates. The article is a continuation of the study of the biography of the command staff of the Siberian Volunteer squad.
V.A. SUKHOMLINSKY ABOUT THE EDUCATION OF TEACHER PEDAGOGICAL ACTIVITY CULTURE
Authors:   Orenburg State Pedagogical University, Orenburg, Russia, Naumenko N.M. , Shurygina O.S. ,   Orenburg State Pedagogical University, Orenburg, Russia
Published: December 2023

Analysis of works by V.A. Sukhomlinsky, reflecting the idea of cultivating a culture of pedagogical activity of a teacher, showed that its theoretical source was the works of outstanding domestic and foreign teachers of the past and the work of contemporary scientists, which contributed to its significant ideological and theoretical enrichment. At the same time, proposed by V.A. Sukhomlinsky, the idea of cultivating a culture of pedagogical activity of a teacher is distinguished by an undeniable scientific novelty. The idea of cultivating a culture of pedagogical activity of a teacher in the pedagogical work of a scientist has gone through three periods in its development: the period of searching and substantiating new ways in working with the personality of a teacher and student; the period of combining the culture of activity and the general culture of the teacher in his professional activity; the period of creation of a local culture-consistent education system (Pavlysh secondary school). Analysis of the practical activities of V.A. Sukhomlinsky in different periods and the works created by him at that time, led to the conclusion that by the mid-60s, a holistic pedagogical concept of the culture of the teacher’s pedagogical activity had developed in the work of the great teacher. In the legacy of V.A. Sukhomlinsky’s idea of cultivating the culture of teacher’s pedagogical activity lies in the fact that a culturally appropriate teacher is an integral person with a moral and humanistic orientation, a high level of general culture, capable of self-realization in activities close to the norms of culture. The culture of the teacher’s pedagogical activity in the light of the stated idea is interpreted by us as an integrative quality of the personality, syncretically combining motivational, cognitive, activity and emotional-evaluative components, as well as such a way of its conscious organization in which both the teacher and the student develop. Based on the analysis of printed and handwritten works by V.A. Sukhomlinsky, the conditions for educating the culture of the teacher’s pedagogical activity are revealed: the organization of a reflexive educational environment; creating an atmosphere of scientific creativity in the teaching staff; emotional coloring of pedagogical activity, which have been tested in the Pavlysh secondary school and remain relevant today.
EDUCATOR WITH A GLIMPSE INTO THE FUTURE
Authors:   Research Institute of the Federal Penitentiary Service of Russia, Moscow, Russia, Mukhin M.I.
Published: December 2023

The range of V. A. Sukhomlinsky’s creative thought is unimaginably wide, 105 years old this year. The pedagogue said his original, innovative word practically on every aspect of education and upbringing. The purpose of the article is to identify and, to the extent possible, reveal the provisions and conclusions of the innovator, which have already played an invaluable role in the enrichment of national education, and those ideas, the use of the potential of which will be the driving force for the development of education in the third millennium.
METHODOLOGY OF CHILD SOCIALIZATION IN V.A. SUKHOMLINSKY HUMANISTIC PEDAGOGY
Authors:   Chelyabinsk State Institute of Culture, Chelyabinsk, Russia, Litvak R.A. , Zaikova O.N. ,   Chelyabinsk State Institute of Culture, Chelyabinsk, Russia
Published: December 2023

The article examines the value of the child upbringing system developed and implemented by V.A. Sukhomlinsky in the process of professional activity. The special significance of the famous scientist is the strategy of this system, built on the anthropological approach in combination with a set of principles: cultural conformity, natural conformity, humanism, value-oriented, as well as the provisions of the system approach. The core of the scientist’s system was spiritual and moral education, the results of which made it possible to mark a new stage in the development of modern pedagogy aimed at supporting the child, which contributed to a change in the views of teachers on the attitude towards the child, interaction in the system “Man — child — society” and form the qualities necessary in the process of socialization. The authors of the article note that in modern conditions the ideas of the scientist acquire a new sound, interpretations, acquire new meanings, allow for an innovative approach in the education system to educate a free, worthy man with a firm position as a citizen of his Fatherland.
PEDAGOGY OF SUKHOMLINSKY IN A MODERN RURAL SCHOOL
Authors:   Glazovsky State Pedagogical Institute named after V.G. Korolenko, Glazov, Russia, Zakharishcheva M.A. , Nelyubina N.A. ,   Uva secondary school No. 2 with in-depth study of individual subjects, Uva, Russia
Published: December 2023

The article is about an experiment that was organized at the Uva School of the Udmurt Republic. V.A. Sukhomlinsky began his professional pedagogical activity at this school during the harsh years of the Great Patriotic War. The teachers of the Uvinsky school preserve the traditions of humane pedagogy and continue their creative search in modern conditions. V.A. Sukhomlinsky’s ideas about patriotic and spiritual and moral education have been introduced into the educational process, extracurricular activities and additional education. “Lessons of kindness”, “Pedagogical Constellation”, “Holiday of Fairy tales” and other events have become traditional holidays at school. The school has a historical and pedagogical museum of V.A. Sukhomlinsky with unique exhibits. Republican pedagogical readings are held annually with the invitation of scientists, teachers of institutions of higher and secondary vocational education, students, public figures, cultural figures, preschool workers. The conference discusses current problems of modern pedagogy, organized the exchange of experience through participation in master classes. The peculiarity of the pedagogical experiment lies in the fact that all teachers of the school take part in it, just as the experiment was organized by V.A. Sukhomlinsky himself in the Pavlysh secondary school led by him.
HISTORICAL AND PEDAGOGICAL ANALYSIS OF V.A. SUKHOMLINSKY’S HOLISTIC PEDAGOGICAL SYSTEM IN THE CONTEXT OF MODERNITY
Authors:   Orenburg State Pedagogical University, Orenburg, Russia, Ryndak V.G. , Bazhenova Yu.A. ,   Orenburg State Pedagogical University, Orenburg, Russia
Published: December 2023

This article was prepared on the eve of the 105th anniversary of the birth of V.A. Sukhomlinsky. To analyze his holistic pedagogical system, we used the main scientific works of the teacher-researcher, substantiated and proven by many years of practice on the issues of education of a comprehensively developed personality, the organization of educational work with students, cooperation of schools, families and the public in the upbringing of children. The problems of the content, methods and forms of teaching, pedagogical creativity and mastery of the teacher, works of art for children are analyzed. His pedagogical heritage is considered as the author’s system of humanistic views based on the understanding of the philosophical truth that education, upbringing and development of a growing personality is, first of all, the affirmation of harmony of mind and heart, where, according to V.A. Sukhomlinsky, a gentle and subtle melody belongs to the heart, which naturally claims to be modern and timely comprehension. The purpose of the article is to show the significance of V.A. Sukhomlinsky’s views in the context of modern and promising development of education and pedagogical science.
SCIENTIFIC AND PEDAGOGICAL HERITAGE OF V.A. SUKHOMLINSKY AND MODERNITY
Authors:   Orenburg state university, Orenburg, Russia, Nevolina V.V.
Published: December 2023

In the year of the teacher and mentor, which was announced by the President of Russia V.V. Putin, special attention is paid to the role of the teaching profession in modern life. The article discusses the relevance of the scientific and pedagogical heritage of V.A. Sukhomlinsky in modern realities of education transformation. Particular attention is paid to the problems of self-development of students and the continuation of the implementation of ideas from the standpoint of their actualization in modern education. Folk pedagogy Sukhomlinsky recognized the personality of the student as the most important life value. The uniqueness and predictability of the principles of V.A. Sukhomlinsky manifests itself in the field of modern education, educational psychology, personality theory, developmental psychology. The teacher-innovator brought up self-esteem in students. His upbringing by work, team, word, beauty, nature was focused on morality and spirituality, on the formation of a thinking subject. Constructive ideas and innovative experience of the teacher-practitioner V.A. Sukhomlinsky have not lost their relevance today. For example, environmental education in modern schools is based on the ideas of V.A. Sukhomlinsky. In continuation of his ideas, we consider pedagogical activity as preventive medicine for society as a whole, since educated and educated people contribute to the sustainable development of society and prevent many social problems, and this is a motivating factor in a health-saving lifestyle. Generalization of practical work experience is realized on the basis of discussion forums, business games, seminars, round tables, where issues of compliance with the principles of health-saving pedagogy in the educational process are discussed. The implementation of organizational forms of interaction provides opportunities for an active dialogue between the subjects of the educational process in the framework of updating the ideas of the pedagogical heritage of V.A. Sukhomlinsky.
PEDAGOGICAL HERITAGE OF V.A. SUKHOMLINSKIY IN A PRACTICE OF TEACHER’S PROFESSIONAL DEVELOPMENT
Authors:   Secondary school no.137, Chelyabinsk, Russia, Kuravin F.V. , Kuravina E.Y. ,   Secondary school no.137, Chelyabinsk, Russia
Published: December 2023

In this article the main aspects of teacher’s professional development, using of pedagogical heritage of V.A. Sukhomlinskiy in a secondary school practical activity are considered. The model of secondary school teacher’s advanced training in an educational institution is introduced.
Methods for Developing Semantically Oriented Virtual Assistants
Authors: Tregubov A. S. , Nemtsev I. S. , Kotelnikova A. А. , Domozhakova D. A.
Published: December 2023

Nowadays, various technologies are used to create intelligent assistants, based both on research in the field of neural networks, natural language text analysis tools, and on the use of semantic modeling tools. Each of these approaches allows you to qualitatively solve certain problems. As part of this work, an intelligent assistant is being developed that combines all these approaches. The purpose of the work is to create an intelligent assistant that performs as a virtual consultant on the organization’s work processes. The development is based on the use of the semantic model of the organization and business processes. To recognize user intents, we use homomorphic and generalized user intents. The system allows decomposing user tasks and creating a consistency of their execution based on the user semantic models and the subject area.
A post-COVID-19 IDEA to strengthen research, innovation, and development in Africa
Authors: Nwaka Solomon , Kah Muhammadou M.O. , Anieke Christian Chikelu
Published: December 2023

Globally, research, innovation, and the associated education and entrepreneurship are essential for youth and socioeconomic development. Governments, universities, research institutions, and private sector play various roles in the innovation value chain. The weak research and innovation systems in Africa are often linked to the overarching challenges of poor financing, inadequate capacity, weak infrastructure, and processes. Many African universities and research institutions are challenged to validate and transition their ideas and discoveries from the laboratory to field evaluation, and downstream development, registration, and commercialization processes. The critical discovery–development interface that is normally driven by the private sector is also not well developed. Overcoming these constraints require concerted local and global partnerships, sharing of available resources and assets, and training and use of suitable Information and Communications Technology and digital tools to boost productivity. Importantly, this requires private sector engagement and development. We discuss how the Innovation Development and Entrepreneurship Africa aims to use available assets in Africa to support institutions and youths to stimulate innovation. Redoubling efforts toward African development in the post COVID-19 era, in alignment with the African Union Agenda 2063 and the Sustainable Development Goals, will require investment in support of these ideals. We offer some policy recommendations in this context.
Late intrathecal retraction of a lumboperitoneal shunt
Authors: Kim Young Ju , Fujita Atsushi , Maeyama Masahiro , Hori Tatsuo , Tanaka Kazuhiro , Sasayama Takashi
Published: December 2023

Background:

Lumboperitoneal (LP) shunt placement is a good option for treating elderly patients with communicating normal pressure hydrocephalus (NPH) who are also on antiplatelet therapy following endovascular treatment of unruptured bilateral internal carotid artery aneurysms. Here, in an 80-year-old male with an LP shunt, the catheter was “pinched” between adjacent spinous processes, resulting in laceration of the catheter and intrathecal catheter migration.

Case Description:

An 80-year-old male was treated with a LP shunt for NPH 1 year after undergoing endovascular treatment of unruptured bilateral internal carotid artery aneurysms. The lumbar catheter was placed at the L2–3 level. Six months later, when he clinically deteriorated, the follow-up computed tomography showed recurrent ventricular enlargement. Further, studies additionally confirmed intrathecal migration of the lumbar catheter, warranting secondary ventriculoperitoneal shunt placement.

Conclusion:

Patients with LP shunts may develop lumbar catheter lacerations secondary to a “pinching” effect from adjacent spinous processes, resulting in intrathecal catheter migration.
Flower waste as a potential substrate for biosurfactant production
Authors: Seikh Julious , Owary Jonali
Published: December 2023

To know the potential of flower waste as a substrate for biosurfactant production, strains of pure isolated fungi F1, F2, F3, F4 and F5 were used for the study. Different screening methods were done to test the production of biosurfactant: Emulsification Index Test, Drop Collapse Test, Oil Spreading Test, CTAB Agar Test and Hemolytic Activity Test. The highest percentage of biosurfactant concentration for Emulsification Index Test i.e. E24 value was shown by F1 and F3 with 54.16%. The highest clearing zone for Oil Spreading Test was shown by F1 and F3 strain with 2.2 cm diameter. The Drop Collapse Test was shown positive by F1 and F3 strain with flattening of 1mm as compared with distilled water. The clearing zone around the wells for hemolytic activity was shown by both F1 and F3 strain. CTAB Agar Test showed that out of the five fungal strains, F1 and F3 showed blue halos around the wells and hence are anionic in nature. Thus, flower waste has the potential for the production of biosurfactant as a low-cost substrate which can yield high value biosurfactant.
In silico studies on characterization of glucosinolate derivatives for inhibition ofcell cycle regulation protein BCL-2
Authors: Maryam Bi , Joy Hoskeri H.
Published: December 2023

Glucosinolates (GSL) are well-known secondary metabolites present in plants belonging to the Brassicaceae family (Cabbage, broccoli, cauliflower and brussels sprouts) and have been studied for their pharmacological properties. Glucosinolate is a sulfur-rich anionic hydrolyzed product which is good for the human diet. Through the enriched diet, the myrosinase enzyme hydrolyzes glucosinolates to form isothiocyanates against bacterial and fungal infections. Glucosinolates also show antimicrobial, anti-inflammatory, anticancer and cholinesterase inhibitor activity. The present study is to evaluate the glucosinolate substructures retrieved from the chemical database and to evaluate to understand that the BCL-2 inhibition showed the tumor growth and induced apoptosis. We retrieved 117 glucosinolate compounds and in silico druglike prediction screened the compounds and molecular docking against the BCL-2 protein structure. Based on the druglikeness analysis, we identified 39 compounds and these compounds were used for the inhibitory study with BCL2 protein. The results show that 2-Methyl-2-propenyl glucosinolate, 4-Methylpentyl glucosinolate, 4-Mercaptobutyl glucosinolate, Glucocapparin, Glucoerucin, Glucolepidiin, Glucoputranjivin, Glucoviorylin, n-Butyl glucosinolate compounds are strongly binding to BCL-2 protein structure by forming three hydrogen bonds and the resultant compounds can be used as a potential lead molecule for BCL-2 inhibitors.
Recent advances in chemopreventive effect of geraniol against endometrial cancer cell lines: A review of key trials based on signalling pathways
Authors: Sakkaravarthy Shanmugapriya , Sukumaran Latha , Chinnasamy Kanagaraj , Murugan Rashika
Published: December 2023

The present study investigated the chemopreventive potential of geraniol by monitoring the tumor incidence and analyzing the status of early response gene, signalling pathways (NF-kB, CREB, cyclic AMP, RAS-MAPK, ERK1/2, p38, PI3K/AKT, PTEN) and also clarifying the significance of DNA methylation alteration during endometrial carcinogenesis type I and type II cells (HEC-155/180, HEC-1A). These genes communicate through a signalling cascade by adding phosphate group to neighboring proteins and this will eventually activate and translocate. This shows that an integrated computational approach combined with biological knowledge could identify expression signatures as potential diagnostic biomarkers common to multiple tumors.
An assessment of the application of magnetic fields in the study of in vitro plant cell and tissue cultivation
Authors: Narasimhan S. , Bindu S.
Published: December 2023

The magnetic field can affect the structure, physiology and biochemistry of plants. The use of magnetic fields on cultured plant cells and tissues is a proven fact. The system to deliver magnetic flux is very important. Experiments have been performed by directly placing cultures in the vicinity of the magnetic field from a permanent magnetic source. Such a system delivered a fixed magnetic strength. Electric magnets are a better mode to deliver magnetic field to plants because it is easy to deliver tailor-made magnetic exposure. Majority of such studies utilized a magnetic field in the order of milliteslas, some of them utilized a high magnetic field upto 17.8 Tesla. The experiments also utilized varying exposure times and differential exposure to the north or south pole. Such studies reported either an increase or decrease of many parameters such as cell size, shape, metabolite content, chlorophyll content and enzyme activity. Most of the studies discussing magnetotropism on plants utilized seeds or intact plants to find out the effect of magnetic fields on plants. Such studies also give some understanding of the mechanism of action. Using a plant cell culture system, it is possible to grow single cells and small cell aggregates. Therefore, in vitro systems offer an excellent tool to understand the mechanism of action at the cellular level.
Management of Terminal Stage CHF Due to Shones Syndrome
Authors:   Department of Internal Medicine, Marshfield Clinic, USA, Elkhedr Ali EA , Elkhidir Sabri ,   Department of Internal Medicine, Marshfield Clinic, USA
Published: December 2023

Background: we report a case of a 23-year-old male with CHF due to Shone’s syndrome s.p multiple open-heart surgeries, aggressive medical therapy, and implanted CRT-D device. He has been managed by pediatric and adult cardiologists, cardiovascular surgeons, nephrologists, and general internists for many years. He came to us with acute respiratory failure, acute kidney injury and fragility due to advanced stage of CHF with reduced ejection fraction. After decent attempts trying to treat him, eventually the decision of transition to hospice care was made. Case Report: He was started furosemide 120 mg IV; the plan was to continue him on diuretics with temporal improvement recorded. As per his Pediatric cardiologist he is an advanced case of CHF with too frequent exacerbations and hospital admissions, and not a candidate of Heart transplant because of guarded prognosis It was also noted that the patient still had frequent hospitalizations with CHF exacerbations complicated with AKI despite maximum medical therapy. With Palliative care, pediatric cardiologist and Nephrologist all involved, the ultimate decision made to discharge home under strict hospice care plan which will be taken care by a home visit nurse provided thought hospice care Agency. Conclusion: The report shed lights on shone syndrome related CHF, the course of the disease, treatment options and ultimate goals of care. In patients who continues to be symptomatic despite maximum medical and surgical therapy, the decision of implementing more invasive treatment options will greatly depend on goals of care and overall weight of risk vs. benefits.
Synthesis And Biological Evaluation of A New Naphthoquinone Derivative, 2-Methylamino-{3-[2-(4-Morpholinyl)-Ethyl]-Amino}-1, 4-Naphthoquinone
Authors:   Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Bangladesh, Hossen Delour , Al Mahmud Zobaer ,   Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Bangladesh, Nargis Reyda Rashmia ,   Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Bangladesh, Asaduzzaman Muhammad ,   Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Bangladesh, Qais Nazmul ,   Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Bangladesh
Published: December 2023

1,4-napthoquinone and its derivatives possess significant anticancer, antinociceptive and antimicrobial activities and thus modification of 1,4-napthquinonone might result in generation of a lead compound for the development of more effective drug therapy against cancer, pain disorders and bacterial infections. In the present study, 2-methylamino-{3-[2-(4-morpholinyl)-ethyl]-amino}-1,4- Naphthoquinone was synthesized and then evaluated for cytotoxic, antimicrobial and antinociceptive activity. In MTT-based cytotoxicity assay, the compound exhibited strong cytotoxic activity against HeLa cell line with a LD50 value of 17.5μg/ml. In antimicrobial susceptibility test performed by agar disc diffusion method, the compound exhibited promising antibacterial activity against both Grampositive and Gram-negative bacteria with 17-20mm of diameter of zone of inhibition suggesting that the synthesized compound possesses a broad spectrum of antibacterial activity. The compound also demonstrated promising antifungal activities against Saccharoromyces cerevisiae, Candida albicans and Aspergillus nigar. In the acetic acid-induced writhing test in mice, at a dose of 50 mg/kg body weight, the compound displayed significant analgesic activity with 68.3% writhing inhibition which was comparable to that of the standard aceclofenac. These results suggested that the synthesized napthoquionone analog possesses remarkable cytotoxic, antinociceptive and antimicrobial activities and thus could be a potential lead for the development of drug against cancer, infections and pain disorders.
The Mechanism of CO2 Electroreduction to Multi- carbon Products over Iron Phthalocyanine Single-Atom Catalyst
Authors: Khakpour Reza , Farshadfar Kaveh , Dong Si-Thanh , Lassalle-Kaiser Benedikt , Laasonen Kari , Busch Michael
Published: December 2023

Carbon dioxide reduction reaction (CO2 RR) is a promising method for converting CO2 into value-added products. CO2 RR over single atom catalysts (SAC) is widely known to result in chemical compounds such as carbon monoxide and formic acid that contain only one carbon atom (C1). Indeed, at least two active sites are commonly believed to be required for C-C coupling to synthesize compounds such as ethanol and propylene (C2+ ) from CO2 . However, experimental evidence suggests that Iron Phthalocyanine (PcFe), which possesses only a single metal center, can produce a trace amount of C2+ products. To the best of our knowledge, the mechanism by which C2+ products are formed over a SAC such as PcFe is still unknown. Using density functional theory (DFT), we analyzed the mechanism of CO2 RR to C1 and C2+ products over PcFe. Due to the high concentration of bicarbonate at pH=7, CO2 RR competes with HCO3 – reduction. Our computations indicate, that bicarbonate reduction is significantly more favourable. However, the rate of this reaction is influenced by H3 O+ concentration. For the formation of C2+ products, our computations reveals that C-C coupling proceeds through the reaction between in-situ formed CO and PcFe("0")-CH2 or PcFe("-I")-CH2 intermediates. This reaction step is highly exergonic and requires only low activation energies of 0.44 eV and 0.24 eV for PcFe("0")-CH2 and PcFe("-I")-CH2 . The DFT results, in line with experimental evidence, suggest that C2+ compounds are produced over PcFe at low potentials whereas CH4 is still the main post-CO product.
Synthesis and Structure of Vacancy-Ordered Perovskite Ba6Ta2Na2X2O17 (X = P, V): Significance of Structural Model Selection on Discovered Compounds
Authors: Yamamoto Takafumi , Otsubo Yuya , Nagase Teppei , Kosuge Taiki , Azuma Masaki
Published: December 2023

Ba6Ru2Na2X2O17 (X = P, V) with vacancy-ordered 12H-type hexagonal perovskite with a (c’cchcc)2 stacking sequence of [BaO3]c, [BaO3]h and [BaO2]c’ layers, where c and h represent a cubic and hexagonal stacking sequence, were previously reported by Quarez et al. in 2003. They also synthesized Ba6Ta2Na2V2O17, but the structural refinement was absent. Very recently, Szymanski et al. reported 41 new compounds, including 12H-type Ba6Ta2Na2V2O17, using large-scale ab initio phase-stability data from the Materials Project and Google DeepMind. But their structural refinement was very poor. Here, we report synthesis and structure of Ba6Ta2Na2V2O17, which does not have 12H-type structure, but has a vacancy-ordered 6C-type hexagonal perovskite with a (c’ccccc) stacking sequence of [BaO3]c and [BaO2]c’ layers. We also report the phosphite analog Ba6Ta2Na2P2O17 as a new compound. We claim an importance of careful structural characterization on newly discovered compounds; otherwise, the database constructed will lose credibility.
Identification of Lysosomotropism using Explainable Machine Learning and Morphological Profiling Cell Painting Data
Authors: Tandon Aishvarya , Santura Anna , Pahl Axel , Waldmann Herbert , Czodrowski Paul
Published: December 2023

Lysosomotropism is a phenomenon of diverse pharmaceutical interests because it is a property of compounds with diverse chemical structures and primary targets. While it is primarily reported to be caused by compounds having suitable lipophilicity and basicity values, not all compounds that fulfill such criteria are in fact lysosomotropic. Here, we use morphological profiling by means of the Cell Painting Assay (CPA) as a reliable surrogate to identify lysosomotropism. We notice that only 35% of the compound subset with matching physicochemical properties show the lysosomotropic phenotype. Based on a Matched Molecular Pair Analysis (MMPA), no key substructures driving lysosomotropism could be identified. However, using Explainable Machine Learning (XML), we were able to highlight that higher lipophilicity, basicity, molecular weight, and lower topological polar surface area are among the important properties that induce lysosomotropism in the compounds of this subset.
Real-time microsecond dynamics of single biomolecules probed by plasmon-enhanced fluorescence
Authors: Nooteboom Sjoerd W. , Okholm Kasper R. , Lamberti Vincenzo , Oomen Bas , Sutherland Duncan S. , Zijlstra Peter
Published: December 2023

Biomolecules exhibit dynamics on widely varying timescales, which are critical to their functioning in living systems. Particularly sub-millisecond dynamics, such as low-affinity ligand binding and interactions of individual binding sites within multivalent complexes, remain elusive. These dynamics are typically probed in real-time using single-molecule fluorescence, but photophysics limits it to millisecond timescales. Here, we exploit and optimize the strong plasmonic fluorescence enhancement provided by monocrystalline gold nanoparticles to detect $>10^7$ photons/s from single fluorophores. The ultrahigh signals uniquely enable real-time single-molecule fluorescence studies with 1-10 $\mu$s temporal resolution, and single-molecule correlation spectroscopy within $<1$ s. We use this method to reveal molecular diffusion and ultralow-affinity DNA interactions on microsecond timescales. We further exploit the field gradient around the nanoparticles to reveal dynamic binding transitions of multivalently binding Holliday junctions. Our results pave the way towards real-time microsecond studies of biomolecular complexes using an implementation compatible with existing single-molecule fluorescence methods.
A Bulky Imidodiphosphorimidate Brønsted Acid Enables Highly Enantioselective Prins-semipinacol Rearrangements
Authors: Lai Junshan , Reid Jolene
Published: December 2023

The development of BINOL-derived Brønsted acid catalysts has been profoundly guided by rational design, with carefully implemented structural changes leading to unique generations of catalysts with enhanced reaction capabilities. This approach to catalyst optimization has promoted the integration of knowledge gathered in optimizing prior eras of Brønsted acids and ultimately, the molecular features that have contributed to the success of previous designs are preserved. Of these, the large substituents at the 3 and 3’ positions of the BINOL backbone are the most critical with almost every newly developed structure possessing this feature. However, imidodiphosphorimidate (IDPi) catalysts are not synthetically well-suited to contain the same sterically bulky groups associated with the high selectivity imparted by previously implemented catalyst structures. Herein, we have leveraged the moderate size (as compared to TRIP and 9-anthryl) but high applicability of the 9-phenanthryl substituent to synthesize a sterically demanding IDPi. Using computed descriptors, we survey the catalyst properties of known structures to demonstrate this catalyst to be both unique and one of the bulkiest IDPi yet synthesized. The applicability of the catalyst was evaluated in the construction of stereochemically dense spirocycles generated via an asymmetric Prins-semipinacol reaction sequence. Transition state calculations were deployed to interrogate the origins of the superior enantioselectivity and these demonstrate the mechanistic hallmarks of the 9-phenanthryl substituent can be generalized to a genuinely different class of Brønsted acid catalyst. Ultimately, providing the basis for the development of general catalyst design principles and the translation of “privileged” substituents across unique eras of Brønsted acid catalyst structures.
Cover and Contents
Authors: Editors
Published: December 2023

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NZAS Finance Report 2011
Authors: Editors
Published: December 2023

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From competition to collaboration: Challenges for New Zealand science
Authors: Penman David , Pearce Andrew , Morton Missy
Published: December 2023

​This article was orginally published in Policy Quarterly 2011, vol.7 (4), and is reproduced here with permission.
Principles of scientific method
Authors: Popper Karl
Published: December 2023

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Sir Paul Callaghan (1947–2012)
Authors: Hendy Shaun , McGrath Kathryn
Published: December 2023

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Super-ministry not good for health or the environment
Authors: Editors
Published: December 2023

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Superconducting Switch Rectifiers using Rotating Magnets
Authors:   , Guja Dylan
Published: December 2023

High temperature superconductors have the potential to enable high field magnet coils and superconducting machines with higher operating temperatures, which require much less cooling power. The challenge is delivering power to the superconducting circuit inside the cryogenic environment without burdening the cryogenic heat load with direct current leads. Several types of flux pump have been developed which have been shown to charge superconducting coils without direct conduction, using magnetic flux. This project involved designing a new type of flux pump which uses rotating permanent magnets to drive a superconducting switch rectifier circuit. There was uncertainty whether the principle would work, so the main objective was to determine whether this type of flux pump was possible to build. The dependence of the maximum load current on switch timing, rotor speed, magnetic flux gap and circuit resistance were investigated to optimise the device. The device was completed and shown to function as a flux pump, with a maximum load current of 15 amps. Experimental results showed a significant dependence on switch timing and rotor speed. There was some evaluation of the effects of magnetic flux gap and circuit resistance on performance. This new device offers significant opportunity for further investigation in future work.
Hubungan Pengetahuan Ibu dan Dukungan Suami terhadap Keberhasilan ASI Eksklusif di Kecamatan Kamal, Jawa Timur
Authors: Prihandani Oky Rahma , Khayana Felisa Nur , Marfu’ati Nanik
Published: December 2023

Latar Belakang: ASI eksklusif sangat bermanfaat bagi bayi dan ibu. Meskipun demikian, cakupan ASI eksklusif masih rendah. Terdapat banyak faktor yang mempengaruhi keberhasilan ASI eksklusif, diantaranya adalah pengetahuan ibu dan dukungan suami. Penelitian ini bertujuan menganalisis hubungan pengetahuan ibu dan dukungan suami terhadap keberhasilan ASI eksklusif.Metode: Penelitian ini merupakan penelitian belah lintang yang dilakukan di wilayah kerja Puskesmas Kamal. Data diperoleh melalui pengisian kuesioner pengetahuan ibu dan dukungan suami oleh ibu dari bayi berusia 6 sampai 12 bulan. Jumlah subjek penelitian adalah sebanyak 96 orang. Sampel dipilih dengan metode consecutive sampling. Pengujian data menggunakan uji fisher exact.Hasil: Hasil penelitian menunjukkan 53,1% responden berhasil memberikan ASI secara eksklusif. Mayoritas pengetahuan ibu adalah baik (74%), dan telah mendapat dukungan suami yang baik (76%). Hasil analisis diperoleh terdapat hubungan yang signifikan antara pengetahuan ibu terhadap keberhasilan ASI ekskusif (p=0,000). Tidak terdapat hubungan yang signifikan antara dukungan suami terhadap keberhasilan ASI eksklusif (p=0,661).Kesimpulan: Pengetahuan ibu berhubungan dengan keberhasilan ASI eksklusif di wilayah kerja Puskesmas Kamal. Dukungan suami tidak berhubungan dengan keberhasilan ASI eksklusif di wilayah kerja Puskesmas Kamal.
Hubungan Antara Neutrophil Lymphocyte Ratio dan Absolute Lymphocyte Count dengan Mortalitas Pasien Covid-19 (Studi Observasional Analitik pada Pasien COVID-19 yang Dirawat Inap di Rumah Sakit Islam Sultan Agung Semarang Periode Mei–Agustus 2021)
Authors: Pertiwi Danis , Aulia Andina Putri , Rahayu Rahayu
Published: December 2023

Latar Belakang: SARS-CoV-2 merupakan virus penyebab COVID-19. Peran penanda inflamasi cukup besar dalam menilai perjalanan penyakit COVID-19, salah satunya Neutrophil Lymphocyte Ratio (NLR) dan Acute Lymphosit Account (ALC) yang menggabungkan neutrofil sebagai komponen inflamasi aktif serta limfosit sebagai regulator dan komponen protektif dalam satu kesatuan parameter. Penelitian mengenai hubungan antara NLR dan ALC dengan mortalitas pasien rawat inap COVID-19 masih terbatas. Oleh karena itu, penelitian ini dilakukan untuk mengetahui hubungan antara NLR dan ALC dengan mortalitas pasien COVID-19 yang dirawat inap di RSI Sultan Agung Semarang.Metode: Penelitian observasional analitik dengan desain kohort retrospektif dengan subjek sebanyak 153 orang pasien COVID-19 yang dirawat inap di RSI Sultan Agung Semarang pada bulan Mei - Agustus 2021. Data diperoleh melalui pencatatan dari rekam medis. Data berskala kategorik dan diuji dengan metode korelasi spearman menggunakan aplikasi SPSS versi 22.Hasil: Didapatkan rerata nilai NLR pasien COVID19 yang sembuh adalah 3,17 dan yang meninggal adalah 14,4. Rerata nilai ALC pasien COVID-19 di RSI Sultan Agung Semarang yang sembuh adalah 2200 /µL dan yang meninggal 1158 /µL. Hasil analisis menunjukkan nilai p = 0,001 dengan nilai r = 0,59 untuk hubungan antara nilai NLR dengan mortalitas pasien COVID dan r = 0,261 untuk hubungan antara nilai ALC dengan mortalitas pasien COVID-19.Kesimpulan: Penelitian ini menunjukan terdapat hubungan bermakna antara nilai NLR dan ALC dengan mortalitas pasien rawat inap COVID-19 di RSI Sultan Agung Semarang.
Hubungan Jumlah dan Indeks Trombosit (MPV, PDW, P-LCR, dan Plateletcrit) dengan D-Dimer pada Pasien COVID-19
Authors: Pradati Subandhini Arika , Rachmawati Banundari
Published: December 2023

Latar Belakang:D-dimer digunakan untuk monitoring pasien COVID-19 namun tidak semua rumah sakit dapat melakukannya sehingga diperlukan adanya pemeriksaan alternatif. Jumlah dan indeks trombosit merupakan parameter yang secara otomatis diukur saat pemeriksaan dengan hematology analyzer. Penelitian ini dilakukan untuk mengetahui hubungan antara jumlah dan indeks trombosit dengan D-dimer pada pasien COVID-19.Metode:Penelitian menggunakan desain observasional analitik dengan pendekatan belah lintang. Sampel penelitian ini menggunakan catatan medik dari 33 pasien COVID-19 berusia 30 – 65 tahun dengan teknik consecutive sampling. Penelitian ini dilakukan pada bulan Juni – Agustus 2021 di RSUP dr. Kariadi Semarang. Analisis data dengan uji Pearson dan Spearman dengan nilai signifikansi p < 0,05Hasil: Dari 33 sampel didapatkan hubungan signifikan antara jumlah trombosit, MPV dan PCT dengan D-dimer (p=0,004; dan r=-0,483); (p=0,042; dan r=0,357); (p=0,000; dan r=-0,611). Tidak terdapat hubungan yang signifikan antara PDW dan P-LCR dengan D - dimer (p=0,872; dan r=-0,029); (p=0,899; dan r= 0,023)Kesimpulan:Terdapat hubungan negatif sedang antara jumlah trombosit dengan D-dimer, positif lemah antara MPV dan D-dimer, positif kuat antara PCT dan D-dimer serta tidak terdapat hubungan antara PDW, P-LCR, dengan D-dimer