bluuebunny/crossref_metadata_2025 huggingface dataset:
Docking, Synthesis and Antimalarial Evaluation of Hybrid Phenyl Thiazole 1,3,5-Triazine Derivatives
Authors: Das Arpita , Ghosh Surajit K. , Bhat Hans Raj , Kalita Junmoni , Kashyap Ankita , Adhikari Nayana
Published: March 2019

Background:

Presentlytheeffectiveness of antifolate antimalarial drugs is decreasing due to
the emergence of resistant Plasmodium strains. The aim of the present study was to determine the antimalarial
effect of hybrid p-bromo phenyl thiazole-triazine derivatives against 3D7 strain of Plasmodium
falciparum.

Methods:

Seventy-fivehybrid derivativeswere designed based on the lead molecule and docking was
done against the active site of Pf-DHFR-TS (PDB i.d. 1J3i) with validated ligand fit protocol by using
Discovery Studio 2.5. Based on the highest binding energy and the best docked pose, fifteen compounds
were selected for the synthesis. Synthesized compounds were characterized by different spectroscopy
methods and in-vitro antimalarial evaluation was done against the 3D7 strain of Plasmodium falciparum.

Results:

Fifteen compounds were synthesized by conventional and microwave assisted method and
were characterized byFT-IR, 1H-NMR, 13C-NMR and Mass spectroscopy. In-vitro antimalarial screening
results showed that compounds ADG303, ADG 306 and ADG 302 have the highest activity against
3D7 strain of P. falciparum. Furthermore, docking result of these compounds having binding energies
of -154.91, -165.981, -137.826 respectively showed similarity with reference compound WR99210
(-152.023) and also bound to Asp54 and Phe 58 amino acid at the active site of the receptor.

Conclusion:

The synthesized compound ADG303 exhibited an encouraging result which could be a
new lead for antimalarial drug discovery.
Assessment of Hepatoprotective and Antiulcer Activity of Launaea aspleniifolia Hook in Laboratory Animals
Authors: Ali Sadik , AnupMaiti  , Vishwakarma Vishal Kumar , Ajay Kumar
Published: March 2019

Background:

Launaea aspleniifolia Hook (Family Asteraceae) is used traditionally in medicine
in Indian system for the treatment of leucoderma. This study was conducted to evaluate the hepatoprotective
and antiulcer effects using the methanolic extract of Launaea aspleniifolia Hook (MELA).

Methods:

The MELA in the dose of 200 and 400 mg/kg body weight (b.w.) was administered orally,
daily for 7 days to prevent the acetaminophen-induced hepatotoxicity and peptic ulcer. In order to determine
the antioxidant enzymes activity, various enzymatic parameters including alanine aminotransferase
(ALT), aspartate aminotransferase (AST), total bilirubin (TBL), direct bilirubin (DBL), alkaline
phosphatase (ALP), total protein (TP), albumin (ALB), high density lipoproteins (HDL), random glucose
test (RBS), serum creatinine levels (SCL) and direct bilirubin (DBL) were determined. Further, the
histopathology of tissue and various gastric secretion parameters like free acidity, total acidity ulcer
score, % ulcer inhibition, gastric volume, pH, Na+ and K+ and histopathology were determined in PLinduced
ulcer model.

Results:

MELA showed dose-dependent hepatoprotective and ulcer protective effect in acetaminopheninduced
hepatotoxicity and antiulcer activity. Furthermore, tissue antioxidant parameter such as reduced
Malondialdehyde (MDA), histopathology was also investigated. MELA was more potent in controlling
all the serological parameter of liver like ALT, AST, TBL, DBL, ALP, HDL, RBS, SCL, TP and ALB
in a dose-dependent manner (P<0.05) induced by Acetaminophen. Apart from this, antiulcer activity
MELA was confirmed by the low level of ulcer index along with the reduction of free acidity, total acidity
ulcer score, % ulcer inhibition, gastric volume, Na+ and an increase K+, pH of gastric content in a
dose-dependent manner (P<0.05) induced PL model.

Conclusion:

The results indicated a significant dose-dependent effect of MELA from injuries induced
in liver and stomach. These protective effects of MELA can be examined in various other toxicities as
alone and in combinations.
Bioactivity Guided Fractionation and Purification of Anti-Depressant Molecule from Ashwagandha (Withania somnifera)
Authors: Antony Benny , Aravind A.P.A. , Benny Merina , Gupta Nishant K. , Joseph Biji , Sebastian Anu
Published: March 2019

Background:

Ashwagandha (Withania somnifera) is an important herb in the Indian traditional
system of medicine for neurological disorders. However, the efforts for isolation and
characterisation of a molecule with anti-depressant activity and development as a potent dosage form
are limited.

Objective:

The objective of the present study was to characterize the Ashwagandha extract for its antidepressant
fraction or constituent and to improve biological benefits at low doses.

Methods:

Aqueous methanol extract of Ashwagandha was prepared and fractionated into withanolides
and flavonoids rich fractions. Withanolide rich fraction was subjected to phytochemical analysis to identify
the active molecule/s. The compound was purified by using a semi-preparative HPLC system; identified
using various spectroscopic techniques and anti-depressant activity was evaluated in rats. Enteric
coating was performed on the extract and fractions after granulation and anti-depressant activity of
coated samples were evaluated in rats.

Results:

Aqueous methanol extract of Ashwagandha and withanolide rich fraction showed prominent
dose-dependent anti-depressant activity in forced swim test in rats. Phytochemical analysis of active
fraction resulted in the isolation and characterization of a major withanolide glycoside present, namely
withanoside X. Enteric coated aqueous methanol extract, withanolide rich fraction and withanoside X
showed significant antidepressant activity at low doses as compared to the uncoated forms.

Conclusion:

The active fraction/isolated compound is sensitive to low pH of the stomach, thus enteric
coating might be beneficial to protect the actives in the stomach, facilitating the sustainable release into
the intestine and in turn reduce the dosage.
Ramelteon in the Treatment of Delirium: New Perspectives from Reported Findings and a Case Observation
Authors: Sanchez Deborah L. , Fusick Adam J. , Hudson William B. , Schmitz Jourdan E. , Catalano Maria C. , Catalano Glenn
Published: March 2019

:

Ramelteon is a melatonin receptor agonist that is approved for the treatment of insomnia. It is widely used due to its relatively benign side effect profile and lack of dependence or withdrawal. Due to its tolerability, clinicians have attempted to utilize ramelteon to normalize the sleep/wake patterns in patients with delirium as a safer alternative to antipsychotics or other medications. We present the case of a 75-year-old man with long-standing dementia who was hospitalized due to mental status changes, agitation, and sleep disturbance. After addressing possible underlying causes with minimal improvement, the team initiated treatment with ramelteon (8mg nightly) which resulted in rapid improvement of symptoms. Uses and mechanisms of action of ramelteon will be reviewed, as well as current pharmacologic treatments of delirium. Prior research studies and case reports regarding the use of ramelteon in the treatment of delirium will be discussed and suggestions made regarding possible areas of future study.
Evaluation of Pyrano[3,2 C] Quinoline Analogues as Anticancer Agents
Authors: Upadhyay Kuldip D. , Shah Anamik K.
Published: March 2019

Background:

Quinoline analogues exhibited diversified biological activities depending on the structure type. A number of natural products with pyrano[3,2-c]quinolone structural motifs and patented chromenes were reported as promising cytotoxic agents.

Objective:

The present study is aimed to evaluate a new series of pyrano[3,2-c]quinoline scaffolds derived from the fusion of bioactive quinolone pharmacophore with structurally diverse aryl substituted chromene for its cytotoxicity.

Methods:

A library of pyrano[3,2-c]quinoline analogues was prepared from one-pot multi component synthesis using various aromatic aldehydes, malononitrile and 2,4-dihydroxy-1-methylquinoline. The new synthetics were primarily screened for its cytotoxicity (IC50) against different human cancer cell lines in vitro. The promising synthetics were further evaluated in vitro for their potency against different kinase activity. The promising compounds were finally tested for their in vivo efficacy in SCID type mice HCT-116 tumor model.

Results:

The screening results revealed that compounds 4c, 4f, 4i and 4j showed promising activity in in vitro study. However, compound 4c was found to be the most potent candidate with 23% tumor growth inhibition in HCT-116 tumor mice model.

Conclusion:

The structure activity relationship suggested that 3-substitution on the aryl ring at C4 position of the pyrano[3,2 c]quinolone moiety seems to have an important position for cytotoxicity activity. However, 3- chloro substitution at C4 aryl ring showed a significant alteration of the bioactive conformer of the parent scaffold and outcome with compound 4c as the most potent candidate of the series.
The Value of Soluble Transferrin Receptor and Soluble Transferrin Receptor-ferritin Index in Discriminating Iron Deficiency Anaemia from Anaemia of Chronic Disease in Patients With Rheumatoid Arthritis
Authors: Al-Rubaie Haithem A. , Al-Bayaa Israa M. , Al-Amiri Yassmin A.
Published: March 2019

Background:

Anaemia is a common extra-articular manifestation of rheumatoid arthritis (RA) where anaemia of chronic disease (ACD) and iron deficiency anaemia (IDA) are the two most frequent types. The distinction between these two types of anaemia has always been challenging requiring sophisticated techniques. Serum transferrin receptor (sTfR) a truncated soluble form of the transferrin receptor is one of the parameters that is influenced by the Iron content and supply to the erythrons and is not affected by inflammatory status and therefore the use of the sTfR/log ferritin (sTfR-F) index can be a reliable indicator of functional iron deficiency.

Aim of the study:

This study aims to evaluate the usefulness of sTfR and sTfR-F index in discriminating the most common types of anaemia in patients with RA.

Patients and methods:

The study included 50 patients with RA and 30 healthy subjects as a control group. Complete blood picture, C-reactive protein, serum Iron, unsaturated iron binding capacity, sTfR and serum ferritin were tested.

Results and Conclusion:

anaemia was present in 34/50 patients; 19 patients had ACD, 9 had ACD/IDA and only 6 patients had IDA. Both the sTfR and the sTfR-F index showed a significant difference between anaemia groups (P values = 0.037 and 0.001, respectively). sTfR-F index has shown to be a very useful parameter that can discriminate efficiently between IDA and ACD and between ACD and ACD/IDA in patients with RA.
Investigation of Optical and Dielectric Constants of Benzobis(thiazole)- based Copolymer Films
Authors: Su Yue , Yang Ailing , Zhang Wenzhe , Wen Shuguang
Published: March 2019

Introduction:

Copolymer PBB-T with benzo[1,2-d:4,5-d']bis(thiazole) (BBT) as the
accepting unit and benzodithiophene (BDT) as the donor unit is a promising candidate for highperformance
non-fullerene polymer solar cells (PSCs). So far optical and dielectric constants of the
PBB-T are not fully known.

Method:

PBB-T was synthesized and thin films of PBB-T were prepared. By using the Kramers-Kronig
relations and the transmission spectra of the PBB-T films, the optical and dielectric constants, including
in absorption coefficient (α(λ)), extinction coefficient (κ(λ)), refractive index (n(λ)), dielectric constant
(ε1(λ),ε2(λ)), band gap (Eg) and mobility of the PBB-T films were calculated and analyzed.

Result:

At 500 nm, α, κ, n, ε1 and ε2 are 1.65×105 cm-1, 0.46, 1.8163, 3.0 and 1.65 respectively.
Eg is 2.111 eV. The hole mobility of PBB-T are 2.41×10-5 cm2 V-1 s-1 and 1.71×10-4 cm2 V-1 s-1 for
the as-cast film and for the solvent vapor annealed film respectively. The results show that these
optical and dielectric constants of the PBB-T films are almost independent on the thicknesses of
the films, indicating our results are reliable. The features of the optical and dielectric constants
show the PBB-T films are very promising candidates for high-performance non-fullerene PSCs
and potential cut-off filter only permitting red and near-infrared light passing.

Conclusion:

These results are significant for designing optoelectronic devices related to the PBBT
thin films.
Unusual Enthalpy Driven Self Assembly at Room Temperature with Chitosan Amphiphiles
Authors: Odunze Uchechukwu , O'Brien Fionn , Godfrey Lisa , Schätzlein Andreas , Uchegbu Ijeoma
Published: March 2019

Background:

GCPQ (N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-
6-O-glycolchitosan) is a self-assembling polymer being investigated as a pharmaceutical
nano-carrier. GCPQ nanoparticles shuttle drugs across biological barriers, improving
drug performance. The exact chemistry of GCPQ is varied by the relative proportion of
hydrophobic (N-palmitoyl) and hydrophilic (quaternary ammonium) groups and molecular
weight.

Objective:

We hypothesised that the thermodynamics of self-assembly is controlled by the
polymer molecular weight and hydrophobicity.

Method:

The thermodynamics of self-assembly was investigated using isothermal calorimetry.

Results:

GCPQs (Mw = 8-15 kDa) formed micellar aggregates at critical micellar concentrations
of 1-2.4 µM at 25°C and micellisation was unusually enthalpy driven. There was a
positive correlation between ΔHmic and mole% quaternary groups (Q): ΔHmic = 3.8 Q-
159 (r2 = 0.93) and a negative correlation between ΔHmic and molecular weight (Mw):
ΔHmic = -13.5 Mw-26.3 (r2 = 0.99).

Conclusion:

These findings provide insights into the positive drivers of stable selfassemblies,
namely hydrophobicity and molecular weight, as both hydrophobicity and molecular
weight are associated with an increased enthalpy contribution to micellisation.
Understanding the Significance of Microwave Radiation for the Graft Copolymerization of Acrylamide on Carboxymethyl Xanthan Gum
Authors: Badwaik Hemant R. , Alexander Amit , Sakure Kalyani
Published: March 2019

Background:

Nowadays, microwave assisted techniques are becoming popular ecofriendly
approaches in Green Chemistry. However, to date, no study has reported the microwave assisted
graft copolymerization of acrylamide on carboxymethyl xanthan gum backbone.

Objective:

The objective of this study was to study the effect of microwave radiations on graft copolymerization
of acrylamide on carboxymethyl xanthan gum.

Methods:

Carboxymethyl xanthan gum was grafted with acrylamide under microwave irradiation.
The grafting process is optimized by varying the amount of carboxymethyl xanthan gum, acrylamide,
ammonium persulphate, microwave power and exposure time. The graft copolymer was further characterized
and evaluated for its efficacy.

Results:

Grafting was successfully optimized for higher grafting efficiency (92.4 %) and grafting
(410.5 %) in a short reaction time of 150 s, at 40 times less concentration of ammonium persulphate.
The characterization study confirmed the grafting of acrylamide on the hydroxyl group of carboxymethyl
xanthan gum backbone.

Conclusion:

Microwave radiations play a vital role in graft copolymerization of acrylamide on carboxymethyl
xanthan gum, in short reaction time, at 40 times less concentration of initiator. The synthesized
graft copolymers remain nontoxic and also showed more antimicrobial activity than carboxymethyl
xanthan gum.
Organophotoredox Catalysis: Visible-light-induced Multicomponent Synthesis of Chromeno[4, 3-b]chromene and Hexahydro-1H-xanthene Derivatives
Authors: Sharma Amit K. , Tiwari Jyoti , Jaiswal Deepali , Singh Shailesh , Singh Jaya , Singh Jagdamba
Published: March 2019

Background:

In recent years, photoredox catalysis using eosin Y has gained considerable significance in organic chemistry. It is evolving as a powerful approach in modern organic synthesis for the activation of small molecules.

Objective:

The use of organic dyes to convert visible light into chemical energy by involving a single-electron transfer with organic substrates has innumerable applications.

Method and Results:

The present strategy is the first example of visible light promoted, aerobic, oxidative cyclization of chromeno[4,3-b]chromenes and hexahydro-1H-xanthenes via the formation of C–O and C–C bonds to afford excellent yield of the products in a simple one-pot operation under mild reaction conditions.

Conclusion:

The major advantages of the present methodology include short reaction time, cost effectiveness, easy work-up, broad substrate scope and high atom economy.
Improving the Health of Individuals With Cerebral Palsy: Protocol for the Multidisciplinary Research Program MOVING ON WITH CP (Preprint)
Authors: Alriksson-Schmidt Ann , Jarl Johan , Rodby-Bousquet Elisabet , Lundkvist Josenby Annika , Westbom Lena , Himmelmann Kate , Stadskleiv Kristine , Ödman Pia , Svensson Ingrid , Antfolk Christian , Malesevic Nebojsa , Jeglinsky Ira , Saha Sanjib , Hägglund Gunnar
Published: March 2019

BACKGROUND

Cerebral palsy (CP) is one of the most common early onset disabilities globally. The causative brain damage in CP is nonprogressive, yet secondary conditions develop and worsen over time. Individuals with CP in Sweden and most of the Nordic countries are systematically followed in the national registry and follow-up program entitled the Cerebral Palsy Follow-Up Program (CPUP). CPUP has improved certain aspects of health care for individuals with CP and strengthened collaboration among professionals. However, there are still issues to resolve regarding health care for this specific population.

OBJECTIVE

The overall objectives of the research program MOVING ON WITH CP are to (1) improve the health care processes and delivery models; (2) develop, implement, and evaluate real-life solutions for Swedish health care provision; and (3) evaluate existing health care and social insurance benefit programs and processes in the context of CP.

METHODS

MOVING ON WITH CP comprises 9 projects within 3 themes. Evaluation of Existing Health Care (Theme A) consists of registry studies where data from CPUP will be merged with national official health databases, complemented by survey and interview data. In Equality in Health Care and Social Insurance (Theme B), mixed methods studies and registry studies will be complemented with focus group interviews to inform the development of new processes to apply for benefits. In New Solutions and Processes in Health Care Provision (Theme C), an eHealth (electronic health) procedure will be developed and tested to facilitate access to specialized health care, and equipment that improves the assessment of movement activity in individuals with CP will be developed.

RESULTS

The individual projects are currently being planned and will begin shortly. Feedback from users has been integrated. Ethics board approvals have been obtained.

CONCLUSIONS

In this 6-year multidisciplinary program, professionals from the fields of medicine, social sciences, health sciences, and engineering, in collaboration with individuals with CP and their families, will evaluate existing health care, create conditions for a more equal health care, and develop new technologies to improve the health care management of people with CP.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/13883
Suicide Prevention Mobile Apps: Descriptive Analysis of Apps from the Most Popular Virtual Stores (Preprint)
Authors: Castillo-Sánchez Gema , Camargo-Henríquez Ismael , Muñoz-Sánchez Juan Luis , Franco-Martín Manuel , de la Torre-Díez Isabel
Published: March 2019

BACKGROUND

Provision of follow-up and care during treatment of people with suicidal intentions is a challenge for health professionals and experts in information and communications technology (ICT). Therefore, health professionals and ICT experts are making efforts to carry out these activities in collaboration by using mobile apps as a technological resource.

OBJECTIVE

This study aimed to descriptively analyze mobile apps aimed at suicide prevention and to determine relevant factors in their design and development. In addition, it sought to analyze their impact on the support of treatment for patients at risk for suicide.

METHODS

We considered 20 apps previously listed in the article “Mobile Apps for Suicide Prevention: Review of Virtual Stores and Literature” (de la Torre et al, 2017;5[10]:e130). To find the apps in this list, the most popular app stores (Android and iOS) were searched using the keyword “suicide prevention.” The research focused on publicly available app information: language, platform, and user ratings. The results obtained were statistically evaluated using 16 parameters that establish various factors that may affect the choice of the user, and the consequent support that the app can offer to a person at risk for suicide.

RESULTS

Of the 20 mobile apps, 4 no longer appeared in the app stores and were therefore excluded. Analysis of the remaining 16 apps sampled showed the following: (1) a high percentage of the apps analyzed in the study (n=13, 82%) are provided in English language; (2) the sampled apps were last updated in 2017, when only 45% of them were updated, but the constant and progressive update of treatments should be reflected in the apps; and (3) the technical quality of these apps cannot be determined on the basis of the distribution of scores, because their popularity indices can be subjective (according to the users). User preference for a particular operating system would require further, more specific research, including study of the differences in the technical and usability aspects between both platforms and the design of medical apps.

CONCLUSIONS

Although there are positive approaches to the use of apps for suicide prevention and follow-up, the technical and human aspects are yet to be explored and defined. For example, the design and development of apps that support suicide prevention should be strongly supported by health personnel to humanize these apps, so that the effectiveness of the treatments supported by them can be improved.
Economic burden and treatment patterns for patients with diffuse large B-cell lymphoma and follicular lymphoma in the USA
Authors: Ren Jinma , Asche Carl V , Shou Yaping , Galaznik Aaron
Published: March 2019

Aim:
Diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) are common types of non-Hodgkin's lymphoma, and real-world evidence continues to be lacking for healthcare costs and utilization among DLBCL and FL patients. Our study aims to describe medical and pharmacy costs and health resource utilization and to characterize longitudinal treatment patterns among these patients.
Methods:
A retrospective observational study was performed among adult patients with DLBCL or FL using the US MarketScan (Truven) administrative claims data from 1 January 2007 to 31 December 2015. Diagnoses of DLBCL and FL were based upon ICD-9 codes. Identifications of treatment lines involved 30 lymphoma-specific anticancer systemic agents. Direct healthcare costs and utilizations were computed in the 1-year postdiagnosis period. Generalized linear models with a gamma link were used to compare healthcare costs between therapies with and without rituximab.
Results:
A total of 2767 DLBCL and 5989 FL patients received frontline therapy. The majority received treatment within 3 months after initial diagnosis (DLBCL 79.9% and FL 62.4%) and were treated with rituximab or bendamustine either alone or in combination (DLBCL 67.4% and FL 84.7%). The total healthcare costs were US $15,555 and $10,192 per patient per month within 1 year following their initial diagnosis for DLBCL and FL, respectively. The medical costs were nearly twice as much as the drug costs for DLBCL patients. Both DLBCL and FL patients receiving rituximab had higher pharmacy costs but lower medical costs (p < 0.001). During the first year following initial diagnosis, the resource utilization (per patient per month) of DLBCL patients included 0.21 inpatient admissions, 0.26 radiation therapy, 2.63 outpatient or office visits, 0.18 emergency room visits, 0.06 intensive care unit admissions and 0.10 stem cell transplantation. FL patients occupied less health resources than DLBCL patients.
Conclusion:
The healthcare costs and health resources utilized were considerable in non-Hodgkin's lymphoma, especially DLBCL patients.
Relación entre estrategias de aprendizaje y rendimiento académico: estudiantes de enfermería, Universidad Santo Tomás
Authors: Mercado-Elgueta C. , Illesca-Pretty M. , Hernández- Díaz A.
Published: March 2019

Las estrategias de aprendizaje son actividades o procesos mentales que llevan a cabo los/as estudiantes, intencionalmente para procesar, entender y adoptar la información que reciben en el proceso educativo.

Objetivo: Describir las estrategias de aprendizaje de estudiantes de la Carrera de Enfermería, Universidad Santo Tomás Temuco-Chile, y determinar la correspondencia entre ellas con el rendimiento académico y variables sociodemográficas.

Métodos: Se realizó un estudio no experimental de corte transversal. La muestra, no-probabilística, de conveniencia, conformada por 185 estudiantes de enfermería de todos los niveles. Se utilizó la Escala de Estrategias de Aprendizaje ACRA-Abreviada (Adquisición, Codificación, Recuperación y Apoyo de la información). Se usó el Programa Stata 11.0, para comparar promedios la prueba t-test y ANOVA, y la correlación de Pearson, para la relación entre variables cuantitativas.

Resultados: Los estudiantes emplean un número importante de estrategias, principalmente las de repetición y relectura (adquisición) y las de apoyo social (apoyo). Las mujeres utilizan más estrategias que los hombres, encontrándose diferencias en las de selección y organización (codificación) de elaboración (codificación) y de subrayado (adquisición). No se encontraron relaciones consistentes entre el uso de estrategias y el rendimiento académico.

Conclusión: Se conocen un número importante de estrategias y hacen uso de ellas, pero no de manera profunda, empleándolas básicamente como elementos de memorización y apoyo al aprendizaje. Se propone, realizar diagnóstico de estrategias al ingreso universitario, capacitación docente y establecer programas donde se promueva la capacidad en los educandos de gestionar su aprendizaje, y la evaluación autentica de los contenidos.
El papel de la orientación al aprendizaje en la innovación y el desempeño: Un estudio en micro, pequeñas y medianas empresas en San Luis Potosí (México)
Authors: Pastor Pérez María del Pilar , Rodríguez Gutiérrez Paola Isabel , Collado Agudo Jesús
Published: March 2019

Este trabajo presenta los resultados de un estudio empírico en el que se evalúa el papel de la orientación al aprendizaje en el enfoque a la innovación y el desempeño de micro, pequeñas y medianas empresas. Además, se analiza si la edad y el tamaño de la organización influyen en la relación entre aprendizaje e innovación. El método utilizado para la recogida de datos fue el de encuesta a una muestra de 253 empresas de los sectores industria, comercio y servicios en México, en la ciudad de San Luis Potosí. Se estimó un modelo de ecuaciones estructurales y los hallazgos indican que la orientación al aprendizaje influye de manera positiva sobre el desempeño empresarial y el enfoque a la innovación de las empresas de la muestra. Se observa también que el tamaño de la empresa tiene un efecto positivo sobre el enfoque a la innovación; sin embargo, no se encuentra efecto significativo de la edad de la organización en la innovación. Estas conclusiones contribuyen a incrementar la evidencia sobre capacidades de las empresas de menor tamaño.
PENGGUNAAN SAMBUNGAN BAMBU ORI MENGGUNAKAN BAUT PADA KUDA-KUDA DENGA PENGISI MORTAR RESIN
Authors: Haris Muhammad , Prasetyo Lukito
Published: March 2019

PENGGUNAAN SAMBUNGAN BAMBU ORI MENGGUNAKANBAUT PADA KUDA-KUDA DENGA PENGISI MORTAR RESINMuhammad Haris 1,Lukito Prasetyo.21&2 Jurusan Teknik Sipil Fakultas Teknik – Universitas Muhammadiyah MalangAlamat korespondensi : Jalan Raya Tlogomas 246 Malang 65144Email : olfurnitur@yahoo.com, prasetyo_lukito@yahoo.comABSTRACTThe use of bamboo as a construction material as well as the price is quite reasonablebecause less tensile strength to accept the burden and the press is quite high, but the use ofbamboo as a construction material has not maxima. This is due to the coupling stalks ofbamboo structure is usually done using conventional ropes, diarrhea and pegs, so thecoupling is less robust. This gives the impression that the power connection is very low, so lookfor an alternative type of connection is stronger, and therefore needed a study for the connectionstructure of bamboo is more solid, the effect of the use of bamboo ori instruction in connectionto the horses bolt with resin mortar filler.From the tests the maximum compressive strength values obtained material resin mortarspecimens at 32 MPa. From the test results on material specimens tap the value of the maximumcompressive robust to be used as filler material in connection ori bamboo horses. Testing theconnection ori bamboo horses given level of loading is: 2000kg, 3000kg, and 4070kg. Bambooeasel Smbungan ori show damage upon receiving load of 4070 kg with a deflection of 8.02mm.Damage to the specimen material is different, this is due to the percentage of the added materialand a different impact. While damage to the connection ori bamboo horses are different, this isdue to the function of each connection is different.Keywords: Bamboo, Resin Mortar, Compressive Strength, Deflection
Cover Jurnal Media Teknik Sipil Vol. 13, No.2. Agustus 2015
Authors: . Cover
Published: March 2019

Cover Jurnal Media Teknik Sipil Vol. 13, No.2. Agustus 2015
Evaluasi Kebutuhan Angkutan Angkutan Umum Penumoang Kota Malang (Studi Kasus Rute Arjosari-Dinoyo-Landungsari)
Authors: Abadi Khoirul , Ruskandi Ruskandi
Published: March 2019

Public transport passengers in Malang called angkot is one of the means of transportation that allows people to perform daily activities, but transport is increasingly interested in the community due to the low level of services, so that many people to using private vehicles. The fleet of public transport passengers (FPTP) routes ADL is currently 118 units with a capacity of 12 passenger/vehicle. Purpose of this study is to determine the performance, productivity and the needs of FPTP ADL optimal trajectory in the city of Malang. The method used in this study adopts the Technical Guidelines for the Implementation of Public Transport in Cities in Fixed Route and Regular (Direktorat Jendral Perhubungan Darat 2002) and using empirical formulations. The study of public transport performance passenger route ADL in 2015, the average load factor of 97.06%, the average frequency of 23.56 vehicle/hour, average headway time of 2.60 minutes, the average travel time 4,10 min/km, average travel speed of 15.03 km/hour. The average productivity of 55 passenger/day-vehicle with optimal fleet size is 116 units.
STUDI GENANGAN KAWASAN BANJARMASIN UTARA KOTA BANJARMASIN
Authors: Fitriansyah Fitriansyah , Sibawahi Akhmad
Published: March 2019

Kota Banjarmasin yang dikenal sebagai Kota Seribu Sungai terletak di bagian hilir Sungai Martapura yang bermuara di Sungai Barito secara administrasi pemerintahan Kota Banjarmasin memiliki lima kawasan yaitu kawasan Banjarmasin Utara, Banjarmasin Tengah, Banjarmasin Barat, Banjarmasin Timur, dan Banjarmasin Selatan. Dalam rencana tata ruang kota Banjarmasin kawasan Banjarmasin utara merupakan salah satuPusatPelayanan Kota sebagai pusat pertumbuhan utama dan pusat kegiatan wilayah perkotaan, Oleh sebab itu sangat perlu untuk dilakukan Studi Genangan kawasan Banjarmasin Utara untuk menangani genangan di wilayah tersebut. Genangan yang terjadi di Kota Banjarmasin disebabkan oleh air sungai pasang, air hujan maupun hujan yang bersamaan dengan air sungai pasang.Dalam stud igenangan kawasan Banjarmasin Utara dilakukan dengan pengumpulan data survey genangan, penyebab genangan, survey pasang surut sungai, kemudian dilakukan pemetaan genangan. Untuk mencapai tujuan dari studi ini maka perlu dilakukan tahapan-tahapan analisis  berupa : Analisa Hidrologi untuk mengetahi curah hujan rata-rata dan menghitung debit banjir rencana (debit puncak limpasan permukaan) pada DAS, analisa genangan dengan kenaikan elevasi muka air yang di simulasikan dalam peta, dan peta genangan yang diproyeksikan pada peta dibeberapa sub DAS yaitu pada sub DAS Andai, sub DAS Awang, sub DAS Jahri Saleh, sub DAS Kedaung, dan sub DAS Kuin.
Fístula arteriovenosa pial no galénica como causa de hipertensión pulmonar y falla cardiaca en un lactante
Authors: Mora-Bautista Víctor Manuel , Rodríguez-Rangel Diego Andrés , Del Mar Sánchez María , Navas Zully , Rodríguez Vladimir , Ferreira Traslaviña Hugo
Published: March 2019

Las manifestaciones clínicas de las malformaciones vasculares intracraneanas en niños incluyen las derivadas de sangrados, así como las hemodinámicas que dependen del tamaño de la malformación. Algunas pueden consumir un alto porcentaje del gasto cardiaco, y llevar a falla cardiaca o a hipertensión pulmonar derivada del hiperflujo. Se presenta el caso de un lactante con hipertensión pulmonar y falla cardiaca que fue diagnosticada tardíamente, aunque con corrección endovascular dentro de la edad recomendada y buen desenlace neurológico. Se enfatiza en la necesidad de considerar las malformaciones vasculares intracraneales dentro del diagnóstico diferencial de niños con hipertensión pulmonar que no responden al tratamiento.
Qué se debe saber en esclerosis múltiple: 16 preguntas prácticas
Authors: Toro G Jaime , Patiño Jorge , Reyes Saúl , Rivera Juan Sebastián , Ríos Jorge , Noriega Daniel
Published: March 2019

La esclerosis múltiple (EM) es la más frecuente de las enfermedades desmielinizantes del sistema nervioso central. Se trata de una patología compleja, con mecanismos fisiopatológicos aún no elucidados completamente y una presentación clínica variada. Es una entidad crónica, de alto costo para el sistema de salud, y usualmente se asocia a una importante discapacidad en los pacientes afectados. No existe una cura para la EM, sin embargo, se cuenta con más de 13 terapias modificadoras de la enfermedad que actúan en distintas dianas terapéuticas, enlentecen la progresión y mejoran el pronóstico. El objetivo de este escrito es presentar una actualización de EM, a través de 16 preguntas y temas controversiales. Estos 16 puntos responden a dudas puntuales y actuales, son presentados, analizados y, en los casos en los que la evidencia lo permite, se plantean recomendaciones. Las preguntas abordadas incluyen temas como diagnóstico, tratamiento, uso de nuevas tecnologías y manejo de los efectos adversos. Este escrito está destinado a neurólogos, médicos generales, residentes de neurología y cualquier profesional interesado en las enfermedades desmielinizantes.
Effects of Information Technology (IT) on Internal Audit in Southwest Nigeria Universities
Authors: AKINLEYE Gideon Tayo , OLANIPEKUN Comfort Temidayo
Published: March 2019

Abstract: This study examined the effects of information technology on internal audit in Southwest Nigeria Universities. Primary data were employed and questionnaires were distributed to the selected Universities. Out of 180 questionnaires, 152 questionnaires were filled and returned by the respondents. The study employed factor analysis and binary logit regression analysis as estimation techniques. The findings from factor analysis showed that Kaiser-Meyer-Olkin and Bartlettâ€™s tests value was 0.786(78.6%) implying that the variables have a 78.6% variation in the data. The value of components variance revealed 62.750 on component 4 indicating that at component 4 there was 62.8% factor variation in the data. Nonetheless, the logit regression equation revealed that fraud discovery of IT (FD) has a positive and insignificant effect on internal audit. Also, IT effectiveness (ITE) revealed that ITE has a negative and significant effect on internal audit. Equally, asset recovery (AR) exhibited a negative and insignificant effect on internal audit. Furthermore, the external audit (EA) has a positive and insignificant effect on internal audit. This study concluded that a significant relationship exists between information technology and internal audit in Southwest Universities. It was recommended that Universities in Southwest should promote and encourage information technology in the internal audit department and also encourage the external users.
Enhancing the Theory of Planned Behaviour by Incorporating Social Marketing Behavioural Enhancers: A First VS Second Order Confirmatory Factor Analysis Approach
Authors: Christian Ayikwa Lutete , W. De Jager Johan , Dion Van Zyl
Published: March 2019

This study investigated the need to extend the TPB model to SMBE variables as suggested by Ayikwa and De Jager (2017) in the quest to better understand sexual behavioural patterns using the Confirmatory Factor Analysis (CFA) approach. The main research question to be answered: "how the TPB and SMBE variables should be structured into a validated CFA model?" Data were carefully collected in South Africaâ€™s Gauteng Province using a disproportionate multi-stage stratified random sampling method to retain 607 respondents. The survey questionnaires distributed consisted of revisited pre-existing instruments. The data were then analysed by CFA model that followed Exploratory Factor Analysis (EFA) to determine the suitability of the sample size. Assessment of the second order extended TPB model confirmed that it is worthwhile to integrate SMBE variables while extending the TPB model in the context of HIV/AIDS related behaviours.
Effect of Corporate Taxation on the Profitability of Firms in NIGERIA
Authors: Olatunji Olaoye Clement , Oluwatoyin Alade Elizabeth
Published: March 2019

The paper examined the effect of corporate taxation on the profitability of some selected firms in Nigeria from 2007 to 2016 using secondary data which was sourced from various publications of the firmsâ€™ financial report. The study employed pooled ordinary least square as the estimation technique. The analytical results revealed that the coefficient of corporate tax on profit after tax was positive with the value of 2.418830 and its P-values were 0.0000, the coefficient of value-added tax was 14.51298 and its p-value was 0.0000. Equally, the coefficient of withholding tax was positive with the value of 7.256489 with p-value 0.0000. Furthermore, education tax result depicts that the coefficient is 36.28245 and it p-value is 0.0000. However, the study concluded that corporate tax rate and education tax as the major taxes paid by companies have positive and significant effects to influence profit after tax. It is also clinched that value-added tax rate and withholding tax being used as other variables that could have effects on profit after tax equally revealed positive and significant effects on profit after tax. Therefore, the study recommended that the government and relevant tax authorities should improve in the administration of corporate taxes to avoid non-compliance
Is the Public Private Partnership Model the Right Vehicle for Public Infrastructure Delivery in Developing Countries?
Authors: Mabuza Patrick
Published: March 2019

There has been an increase in the number of governments that adopted public-private partnership (PPP) as an infrastructure delivery model. However, there are still misgivings about the role PPPs play in developing countriesâ€™ economies. The objective of this study is to address the question of whether the PPP model really benefits the public. This study follows a qualitative approach based on international review of literature on PPP experiences around the world. The results of the study indicate that, the PPP model can be a good vehicle for delivering public infrastructure projects in developing countries. However, for PPPs to meet the expectations of the public sector and the citizens there are certain aspects that need to be in place i.e. transparency, accountability, optimum risk allocation/sharing, and increased competition to name just a few. If a country implements its PPP programme properly, there are massive benefits compared to the public procurement approach that may accrue to consumers and the economy as a whole. Such benefits include reduced prices, which may also increase access to services. The study has elucidated valid from invalid arguments about PPPs and has established whether the PPP model is indeed the right vehicle for delivering infrastructure projects.
Does the presence of maxillary central incisor edge asymmetry influence the perception of dentofacial esthetics in video analysis?
Authors: Sobral Marcio Costa , Crusoé-Rebello Iêda Margarida , Machado Andre Wilson
Published: March 2019

Objective:

To investigate the influence of incisal edge asymmetry of the maxillary central incisors on dentofacial esthetics among orthodontists, prosthodontists, and laypersons using video analysis.

Materials and Methods:

Full-face films of a 52-year-old afro-descendant woman displaying various levels of incisal wear in the esthetic zone were captured. An acrylic resin mockup was made of the maxillary anterior region, enabling the reproduction of an attractive smile and restoring tooth wear. Four different levels of incisal asymmetry between the upper central incisors in 0.5 mm increments were prepared from this mockup. A film was made for each level of asymmetry (0.5, 1.0, 1.5, and 2.0) and one with no asymmetry, with the patient repeating a sentence, totaling five films. After a pilot study and sample calculation, the films were evaluated by 138 examiners: 46 orthodontists, 46 laypeople, and 46 prosthodontists. Each examiner evaluated the dentofacial esthetics of each film using visual analog scales. Data collected were statistically analyzed.

Results:

Highest scores were awarded to the film with no asymmetry between upper centrals and the one with 0.5 mm of asymmetry. The asymmetries of 1.5 mm and 2.0 mm had the lowest scores from all three groups.

Conclusions:

The results of this video analysis indicate that asymmetries equal to or greater than 1.0 mm between the upper central incisors edges jeopardize dentofacial esthetics.
Technologies for fall risk assessment and conceptual design in personal health record system
Authors: Immonen Milla Sinikka , Similä Heidi , Lindholm Mikko , Korpelainen Raija , Jämsä Timo
Published: March 2019

Falls among older people are a major economic and public health problem. Due to the demographic change and aging of populations, there is an urgent need for accurate screening tools to identify those at risk to target effective falls prevention strategies. Clinical fall risk assessments are costly and time-consuming and thus cannot be performed frequently. Technologies provide means for assessing fall risk during daily living, making self-evaluations and fast methods for fall risk assessment for professional use.

This study collects and evaluates existing technological solutions for fall risk assessment including various different sensor technologies. The study also presents one easy to use solution for assessing fall risk and suggests a concept-design for integrating sensor-based solutions into the Finnish national Kanta Personal Health Record.

The optimal solution for technological fall risk assessment is still unclear. A wide implementation still requires extensive validation studies, adoption to health care processes and novel IoT -solutions for collecting large amounts of sensor data. Thorough methods should be utilised in designing the privacy and security aspects of fall risk assessment solutions, as well as different user profiles, to allow suitable interfaces and visualisations to users. It should always be clear what kind of data are collected from users and how the data are utilised. The consent of the users should also always be collected.
Terveydenhuolto ja kyberuhkat
Authors: Norri-Sederholm Teija , Laitinen Tiina , Lehto Martti , Kari Martti J
Published: March 2019

Kyberturvallisuusstrategian vision mukaan Suomen tulee kyetä suojaamaan elintärkeät toimintonsa kyberuhkaa vastaan kaikissa tilanteissa. Terveydenhuolto on yksi elintärkeistä toiminnoista. Terveystoimiala on kyberhyökkäysten top-5-listalla ensimmäisenä. Hyökkäysten keskeisin motivaatio on potilastietojen arvo pimeillä markkinoilla. Vuonna 2015 varastettiin yli satamiljoonaa potilastietoa, jotka sisältävät rikollisille arvokkaita tietoja, kuten luottokorttinumeroita, työnantajatietoja ja sairaushistoriatietoja. Tässä artikkelissa kuvataan terveydenhuoltoon liittyviä kyberuhkia, kyberhaavoittuvuuksia ja toteutuneita kyberhyökkäyksiä kybermaailman eri ulottuvuudet kattaen.

Tarkastelussa käytetään kybermaailman viisikerroksista verkostomallia, joka sisältää fyysisen, syntaktisen, semanttisen, palvelu- ja kognitiivisen kerroksen. Malli kattaa laajasti koko kybermaailman fyysisen kerroksen laitteista ja verkoista kognitiivisen kerroksen inhimillisiin ongelmanratkaisu- ja tulkintaympäristöihin. Haavoittuvuuksia ja toteutuneita hyökkäyksiä voidaan mallin mukaan jaotella laitekohtaisista haavoittuvuuksista aina koulutuksen puutteista johtuviin haavoittuvuuksiin ja pelottelu- ja kalasteluohjelmilla tapahtuneisiin hyökkäyksiin. Paljon julkisuutta ovat saaneet myös terveydenhuoltoon kohdistuneet kiristyshaittaohjelmahyökkäykset.

Kyberuhkia vastaan voidaan suojautua useilla eri tasoilla ja tavoilla. Lähtökohtana on se, että jokainen organisaatio huolehtii oman toimintansa kyberturvallisuudesta tehden yhteistyötä muiden toimijoiden kanssa uhkien tunnistamisessa ja torjumisessa. Terveydenhuollon kyberturvallisuuden rakentaminen on systeemin hallintaa, jossa tulee keskittyä järjestelmien kokonaisuuteen yksittäisten laitteiden sijaan. Yhteistoiminnan tavoitteena on, että kokonaisosaaminen tukee yksittäisen toimijan toimintaedellytyksiä yhteistä uhkaa vastaan. Terveydenhuollon kyberturvallisuuden jatkuva parantaminen ja tietoisuuden lisääminen ovat kaikkien kansalaisten etuja, jotka vaativat vahvaa ymmärrystä niin tietoturvasta kuin terveydenhuollon toimintatavoistakin. Tämän vuoksi tietoisuuden kohottamisen ja henkilökunnan kouluttamisen tuleekin olla keskeisellä sijalla organisaatioiden kyberturvallisuudessa.
Ziyaretçi Memnuniyetinin Ölçülmesinde Önem Performans Analizinin (ÖPA) Kullanılması: Çanakkale Savaşları Gelibolu Tarihi Alanı Örneği
Authors: Yıldırım Hacı Mehmet
Published: March 2019

Bu çalışmanın amacı
Türk ve dünya tarihinde önemli bir yeri olan Çanakkale Savaşları Gelibolu
Tarihi Alanı’nda sunulan hizmetlerin ziyaretçiler açısından önem ve performans
düzeylerini belirlemek, ziyaretçilerin memnuniyetlerini ve ziyaret sonrası
düşüncelerini ortaya koymaktır. Bu bağlamda Çanakkale Savaşları Gelibolu Tarihi
Alanı’nı ziyaret eden 356 kişiden anket yoluyla veriler elde edilmiştir.
Yapılan analizler sonucunda; alanda hizmet veren rehberin bilgi düzeyinin,
şehitliklerin ve çevrenin temizliğinin, şehitliklerin bakımlı olmasının,
ulaşımın kolay ve rahat olmasının korunması gereken unsurlar olduğu; alanda
bulunan tuvaletlerin sayısının yanı sıra var olan tuvaletlerin hijyeni ve
alanda satılan yiyecek içeceklerin kalitesinin de yoğunlaşılması gereken
hususlar olduğu tespit edilmiştir. Son olarak alanda sunulan ürün ve
hizmetlerin performansı ile ziyaretten memnuniyet ve başkalarına tavsiye etme
arasında pozitif bir ilişki olduğu sonucuna ulaşılmıştır.