bluuebunny/crossref_metadata_2025 huggingface dataset:
Radium-223 in the Modern Treatment of Metastatic Castration-resistant Prostate Cancer
Authors: Golovko Serhii
Published: July 2021

The objective: is to determine the current role of radium-223 in the emergence of new options in the treatment of patients with metastatic castration-resistant prostate cancer.

Materials and methods. Studies of ERA-223 and ALSYMPCA have identified the role of radium-223 in the treatment of prostate cancer and its impact on human health.

Results. In one such study, ERA-223, it was shown that the combination of abiraterone with radium-223 did not increase survival without symptomatic skeletal events compared with abiraterone plus placebo. In addition, a higher incidence of bone fractures was observed with the combination of abiraterone and radium-223, especially in patients not receiving osteomodulators (denosumab or zoledronic acid). These results have led to some changes in the indications for the use of radium-223 in Europe and more careful attention to the state of bone structure in patients with prostate cancer.

An overview of expert recommendations for the prevention and treatment of bone events, as well as the consequences of prolonged targeted therapy in patients with metastatic prostate cancer, which may improve the results of general and cancer-specific survival. Radium-223 has been shown to be an important option for patients with castration-resistant prostate cancer with bone metastases, and monitoring and maintaining bone health is an important factor in prostate cancer patients. It is established that the treatment of this category of patients should begin with androge n deprivation therapy.

Conclusions. A review of the recommendations of urologists, oncologists and radiation oncologists in Europe, who specialize in the treatment of patients with advanced prostate cancer, to maintain bone health, treatment consequences and the role of radium-223 in the treatment of prostate cancer. Based on the analysis of the use of radium-223 in the current treatment of CRPD, preventive measures to maintain bone health are recommended, as well as side effects based on clinical experience.
Prevention of the fetoplacental complex disorders in women at risk and the risk of preterm birth (Literature review)
Authors: Laba O.V.
Published: July 2021

The obstetrician-gynaecologist practitioners consider a woman’s health from her reproductive potential support standpoint, and the problem of miscarriage is considered as one of the most important health problems in the world. The difficulty in solving the premature birth problem is the presence of many factors and preconditions that determine the risks of miscarriage. The article provides an overview of current international guidelines for assessing the root causes and preconditions for preterm birth. The problem of preterm birth risks is discussed, taking into account both the socio-economic living conditions of pregnant women and the factors that accompany the formation of the pathogenesis of preterm birth (placental dysfunction). There were examination and evaluation of the clinical significance of the factors that can lead to dysfunction of the fetoplacental complex (partial placental abruption, low placentation, placental dysfunction, premature placental maturation, placental malnutrition/hypertrophy, polyhydramnios/dehydration, placental abruption syndrome and growth retardation syndrome, fetal-placental blood flow, acute/chronic fetal distress). It was noted that hemodynamic disorders in the placenta depend on both the nature and duration of adverse factors. Those factors are pregnancy in unfavourable terms for the birth of children (up to 18 and after 40 years), high frequency of extragenital pathology, complicated reproductive history, genital infectious diseases (chlamydial infections, trichomoniasis, urogenital mycoplasmosis), smoking during pregnancy, the impact of environmental and economical character.Attention is paid to the hemodynamic disorders assessment (vascularization of the lower uterus) in pregnant women and determination of their role in the fetoplacental dysfunction development. The role of the hemodynamic disorders in the placenta is considered as the morphological and biochemical adaptive reactions abnormality.
Assessment of quality of life and psychological condition of women with chronic inflammatory processes of the pelvic organs on the background of pelvic pain
Authors: Matviikiv N.
Published: July 2021

The objective: was to assess the psychological status and quality of life of women in the treatment of recurrent pelvic inflammatory disease with chronic pelvic pain syndrome.Materials and methods. We observed 100 women of reproductive age who suffered from chronic pelvic pain syndrome in chronic inflammatory processes of the pelvic organs. All women were prescribed antibacterial therapy in combination with antihypoxants and antiplatelet agents. The first group included women (n=48) who were prescribed analgesics domestically due to existing contraindications to the use of non-steroidal anti-inflammatory drugs. The second group of women (n=52) received a rectally non-steroidal anti-inflammatory drug. The second group of women (n=52) received a rectally nonsteroidal anti-inflammatory agent. Patients were interviewed 3 months after treatment: using the Visual Analog Scale (VAS), the McGill Questionnaire, the Spielberger–Hanin Questionnaire, the Depression Center of the US Center for Epidemiological Research, the Beck Depression Rating Scale, and the SF-36 Questionnaire.Results. According to the results of the assessment of quality of life and changes in psychological state, we noticed the following differences. In the group of women who received analgesic medium before muscle therapy, the change in muscle changed but slightly compared with the group of women who were offered the use of nonsteroidal anti-inflammatory drugs. Indicators of quality of life and psychological condition in women of the second group have significantly improved.Conclusions. The results of this study indicate the relationship and comprehensive approach in the treatment of pelvic inflammatory disease, which is accompanied by pelvic pain.
Iron and iron deficiency states: a modern view of the problem
Authors: Kondratiuk V.K. , Kondratiuk K.O.
Published: July 2021

The study of the mechanisms of regulation of iron metabolism, the physiological and pathological role of this trace element in the human body is relevant, scientifically and practically significant, especially against the backdrop of the COVID-19 pandemic. The available data on a decrease in the levels of hemoglobin and iron in the blood serum of patients with coronavirus infection suggest that this infection is associated with the formation of iron deficiency.Numerous studies have shown a negative effect of iron overload and an increased risk of replication of intracellular pathogens as a result of unjustified exogenous iron supplementation. That is why the issue of timely diagnosis and effective correction of iron deficiency and iron deficiency anemia (IDA) is extremely relevant outside of SARS-CoV-2 infection.Latent iron deficiency and IDA are pathological conditions that are constantly identified in clinical practice. These conditions are most common among children, women and the elderly in developing countries. These patient populations require effective repair of iron deficiency and monitoring of iron overload. Effective and safe iron supplements and supplements should be used to prevent / treat anemia. The dietary supplement Richter FerroBio manufactured by Gedeon Richter (Hungary) fully meets these criteria.
Features of hemostasis before and long-term periods in patients after ovarian apoplexy
Authors: Ishak O.M.
Published: July 2021

The objective: to reveal the features of the parameters of the blood coagulation system in women in dynamics – from the acute period of ovarian apoplexy to the long-term postoperative period.Materials and methods. The study involved 82 women (main group, n=82), operated on for ovarian apoplexy, and 30 patients in the control group (n=30), who had no history of this pathology. All patients underwent a comprehensive examination using clinical, instrumental and laboratory research methods. The groups were homogeneous in age (average age was 26,1±2,3 years) and statistically comparable.Results. During the study, it was found that in the acute period of ovarian apoplexy, pathological changes were found in the plasma, vascular-platelet components and the fibrinolytic system of hemostasis, as evidenced by the lengthening of the thrombin time to 22,3±1,32 seconds, an increase in the concentration of fibrinogen to 6,73±0,64 g/l, SFMC up to 0,7±0,03 g/l and platelet hyperaggregation, stimulated by ADF, ristocetin and collagen, and reaching 80%. The extremely high content of D-dimer in the abdominal cavity in patients with ovarian apoplexy indicated increased thrombus formation in the damaged ovary, followed by activation of the fibrinolytic system and lysis of fibrin clots. Genetic thrombogenicity was found in general in 80,4% of patients, including those with a predominant lesion of the folate cycle enzymes - in every second patient.Positive dynamics with a tendency to normocoagulation was observed in the distant postoperative period. In the reference range were SFMC indices in 86,6% of cases, fibrinogen and thrombin time in 89,1% of cases, ristocetin-stimulated aggregatogram in 95,1% of cases (p<0,05).Conclusions. In women who underwent ovarian apoplexy, in the acute period of the disease, pathological changes in the vascular-platelet link of the hemostasis system were observed. The diagnosed thrombophilic disorders could lead to a deterioration in the rheological properties of blood, a violation of the processes of oxygenation and tissue trophism. The dynamic study of the hemostasis system in the acute and late postoperative periods of patients with ovarian apoplexy, as well as the data obtained on the prevalence of genetic thrombogenicity in the examined patients, should be taken into account when managing women from this risk group.
Study of the relationship between the parameters of complex prenatal screening of the first trimester of pregnancy with a risk of the most common aneuploidies
Authors: Oshovskyy V. I.
Published: July 2021

Complex prenatal screening of the first trimester remains the most accessible and effective way of stratifying the risks of fetal chromosomal abnormalities in the general population, which has satisfactory sensitivity and specificity. Over the last decade, due to including additional parameters (average pulsation index of blood flow in the uterine arteries, average blood pressure, placental growth factor concentration, obstetric and somatic anamnesis data), it has also become a tool for determining obstetric risks. The objective: to study the effect of these additional parameters on the accuracy of predicting the most common aneuploidies was made. Materials and methods. The cohort included 2164 pregnant women at 11+0 – 13+6 weeks of gestation, who underwent extended complex screening of the first trimester, which aimed to determine the risk of trisomy on the 21st, 13th and 18th chromosomes in the fetus and calculation risk of perinatal complications, namely: premature birth, preeclampsia and fetal growth retardation. Results. It was found that the history of miscarriage at 13–22 weeks of pregnancy (P=0,0006), increased resistance in the uterine arteries (P=0,0307), decreased concentration of placental growth factor (P=<0,0001) and increased mean blood pressure (P=0,0125) correlate with a high risk of trisomy of chromosome 21. Type I diabetes mellitus in pregnant women (P=0,0477) correlates with an increased risk of trisomy on chromosome 18. The concentration of placental growth factor (P=<0,0001) correlates with an increased risk of trisomy on chromosome 13. Conclusions. The data obtained require detailed analysis in the context of the possibility of optimizing mathematical models for predicting aneuploidy, as well as studying the relationship between markers of trophoblast invasion and chromosomal pathology of the fetus to better understand the mechanisms of first trimester fetal loss and placental dysfunction in the second half of pregnancy.
GAP Bölgesi Koşullarında Atdişi Hibrit Mısır Çeşidine (Zea mays L.) Uygulanan Farklı Azot Gübresi Seviyelerinin Tane Verimi ve Kalite ile Klorofil İçeriklerine Etkisi
Authors: TAŞ Timuçin
Published: July 2021

En önemli makro elementlerden olan azot (N), yüksek biomass a sahip mısır bitkisinin verim ve kalitesinde önemli bir yere sahiptir. Bu çalışma, Türkiye’nin GAP Bölgesi’nde 2019 ve 2020 yılları arasında atdişi hibrit mısır çeşidinin tane verim, kalite ve klorofil içeriği üzerine farklı azot gübresi seviyelerinin etkilerini belirlemek amacıyla yürütülmüştür. Deneme tesadüf blokları deneme desenine göre 3 tekerrürlü olarak dizayn edilmiştir. Çalışmada, orta erkenci (FAO 600-650) olum grubunda atdişi hibrit mısır çeşidine farklı azot (N) dozları (N0, N100, N200, N300 ve 400 kg ha) uygulanmıştır. İki yıl ortalamalarına göre, incelenen özelliklerde yıllar ve azot seviyeleri arasında istatistiksel olarak önemli farklar elde edilmiştir. Yıl ortalama sonuçlarına göre, bitki boyu (BB, cm), klorofil içeriği (Kİ, SPAD), tane verimi (TV, kg ha) ve tane protein oranı (TPO, %) sırasıyla 219.43 (N0) – 291.91 (N300), 32.90 (N0) – 56.75 (N400), 7791.22 (N0) – 15461.18 (N300) ve 7.93 (N0) – 10.76 (N400) arasında değişmiştir. Araştırmanın birinci yılına nazaran ikinci yılında yaşanan çevresel stres koşullarından (yüksek sıcaklık ve düşük nisbi nem) dolayı, bitkilerin gelişimi olumsuz etkilenirken, TPO değerleri olumlu etkilenmiştir. Azot seviyeleri ile TV ve Kİ arasında yapılan regresyon analizinde, yüksek önemli ve quatratic ilişkiler tespit edilmiştir. Optimum tane verimi N300 uygulamasında elde edilmiştir. Koçan tane doldurma dönemi (KTDD)’de klorofil içerikleri 50 SPAD değerlerini geçmiştir.
Hanelerin Balık Tüketim Sıklığına Etki Eden Faktörlerin Sıralı Probit Model ile Analizi
Authors: TERİN Seda , KESKİN Atilla
Published: July 2021

Araştırmada, Van ili İpekyolu ilçesinde hanelerin balık tüketim sıklığına etki eden sosyo-ekonomik ve demografik faktörler belirlenmeye çalışılmıştır. Araştırmanın ana materyalini, Van ili İpekyolu ilçesinde ikamet eden ve oransal örnekleme yöntemi kullanılarak tespit edilen 182 haneden toplanan anket verileri oluşturmaktadır. Araştırmada hanelerin balık tüketim sıklığına etki eden faktörler sıralı probit model ile analiz edilmiştir. Araştırmada hanelerin %92,9’unun balık tükettiği ve %7,1’inin balık tüketmediği belirlenmiştir. Araştırmada, yaş ve hane reisinin bayan olmasının hanelerin balık tüketim sıklığını azalttığı, hanede tüketilen balığı yeterli olduğunu düşünme, hane reisinin evli olması, aylık ortalama balık tüketim harcaması, balığı balıkçıdan satın alma, aylık ortalama hane gelirinin asgari ücretin altında olması, kişi başına düşen balık tüketim miktarı ve hane halkı büyüklüğü değişkenlerinin hanelerin balık tüketim sıklığını arttırdığı belirlenmiştir. Araştırmada, hanelerin büyük bir çoğunluğunun balık tükettiği, kişi başına düşen balık tüketim miktarının Türkiye ortalamasından yüksek ancak dünya ortalamasından düşük olduğu belirlenmiştir. Sonuç olarak hanelerin daha sık balık tüketmesi için annelere yönelik yapılacak eğitim çalışmalarına, taze balığa ulaşım imkânları ve balık restoranlarının sayısının arttırılması konularında yapılacak çalışmalara ihtiyaç olduğu değerlendirilmektedir.
THE EFFECT OF PROFITABILITY AND LIQUIDITY TOWARDS THE CAPITAL STRUCTURE ON RETAIL COMPANIES THAT ARE LISTED IN INDONESIA STOCK EXCHANGE IN THE PERIOD OF 2014 – 2015
Authors: Hidayat Vinny Stephanie , Debbianita Debbianita
Published: July 2021

The aim of this research is to determine the effect of profitability and liquidity towards the capital structure on retail companies that are listed in Indonesia Stock Exchange. The population of this research is whole of the retail companies that are listed in the Indonesia Stock Exchange in 2014-2015. The method used in this research is explanatory research, and the sampling method used was judgement sampling method. Research hypothesis testing using T test, F test, and multiple regression analysis using SPSS version 20.0. The partially effect is shown by T test, except for profitability variable and the simultaneous effect is shown by F Test. The result of this research shows that the profitability and liquidity affect the capital structure simultaneously. Thus, the hypothesis of the research is empirically supported.Keywords: Capital Structure, Profitability, Liquidity, and Retail Companies
PENGARUH TOTAL ASSET TURNOVER, LEVERAGE DAN PROFITABILITAS TERHADAP FINANCIAL DISTRESS
Authors: Hidayat Imam
Published: July 2021

Tujuan dari penelitian ini untuk mengetahui pengaruh total asset turnover, leverage dan profitabilitas terhadap financial distress pada perusahaan sub sektor property dan real estate yang terdaftar di Bursa Efek Indonesia (BEI). Periode waktu penelitian yang digunakan adalah 5 tahun yaitu periode 2015-2019.Populasi penelitian ini meliputi seluruh perusahaan property dan real estate estate yang terdaftar di Bursa Efek Indonesia (BEI) periode 2015-2019. Teknik pengambilan sampel menggunakan teknik purposive sampling. Berdasarkan kriteria yang telah ditetapkan diperoleh 17 perusahaan. Jenis data yang digunakan adalah data sekunder yang diperoleh dari situs Bursa Efek Indonesia. Metode analisis yang digunakan adalah analisis regresi data panel.Hasil penelitian menunjukkan bahwa total asset turnover tidak memiliki pengaruh terhadap financial distress, leverage berpengaruh negatif signifikan terhadap financial distress, profitabiliats berpengaruh positif terhadap financial distress dan manajerial dan likuiditas tidak memiliki pengaruh signifikan terhadap financial distress, dan total asset turnover, leverage dan profitabilitas secara bersama-sama berpengaruh terhadap financial distress.
Internações por Condições Sensíveis à Atenção Primária de um município do interior de Minas Gerais, Brasil
Authors: Almeida Luciana Maria Lauar de , Kassab Gabriel Brum Issa , Gorgens Pollyanna Roberta Campelo , Reis Maria Letícia Costa , Campos Fernanda Fraga , Lucas Thabata Coaglio , Costa Magnania Cristiane Pereira da
Published: July 2021

Objetivo: caracterizar as internações por condições sensíveis à atenção primária de um município do interior de Minas Gerais, Brasil. Método: estudo transversal, descritivo, com coleta de dados secundários de prontuários, provenientes de internações hospitalares. Foi elaborado um formulário de coleta estruturado em três blocos: sociodemográficos; relacionados à anamnese; e relacionados a internação. Foram realizadas as frequências absolutas e relativas das variáveis e utilização do Qui-quadrado de Pearson e o Exato de Fisher, considerando o nível de significância de 5%. Resultados: Foram identificados 663 prontuários, com predomínio de pacientes ≥ 60 anos (70.7%), sexo feminino (54,1%), raça/cor parda e preta (69,5%) e sem registro referente a presença ou ausência de fatores de risco (28,5%). Predominaram os diagnósticos de acidentes vasculares e insuficiência cardíaca congestiva ambos com 13,3%, pneumonia (11,0%), angina (9,5%) e doença bronco pulmonar obstrutiva crônica com 8,4% dos casos. Entre os 45 casos (6,8%) de óbito, 19 (42,2%) foram pacientes que não pertenciam à área com cobertura da equipe de Estratégia de Saúde da Família do município. Conclusão: Os resultados contribuirão para uma adequação e qualificação da gestão dos serviços de saúde e melhor planejamento dos cuidados prestados, assim como, a definição de indicadores de desempenho para atenção primária à saúde da região para que sejam controladas e reduzidas as taxas de hospitalizações evitáveis.
Importância da Equipe Multiprofissional para a recuperação da criança com fenda labiopalatina
Authors: Andrade Carla Alves , Rodrigues Mylena Costa , Santos Walquiria Lene
Published: July 2021

Introdução: Relato de caso de uma criança que nasceu com fenda labiopalatal. Uma alteração que atinge cerca de 1 a cada 800 crianças, podendo ocorrer por diversos fatores incluindo fatores genéticos e o uso de álcool e drogas feito pela mãe durante o período gestacional. Objetivo: Descrever a trajetória de uma criança que nasceu no Distrito Federal com a má formação no lábio e palato, tendo grande parte do seu tratamento realizado no Hospital Regional da Asa Norte. Este estudo mostra as dificuldades encontradas pela criança portadora da malformação, os cuidados necessários no pré e pós-operatório, na realização das cirurgias e os problemas futuros relatados pelos pais da criança. Método: O estudo trata-se de um relato de caso qualitativo e para obter as informações foram utilizados exames, fotos, entrevistas  feitas com o pai e a mãe da criança e uma revisão de literatura como forma de complemento. Resultado: O caso relatado mostra que quanto antes a criança for submetida aos cuidados necessários, melhor será o resultado final dos tratamentos, evitando assim, que essa condição possa causar transtornos maiores para a vida da paciente conforme for crescendo. Conclusão: O trabalho realizado pela equipe multiprofissional em conjunto com a família da criança, são fundamentais para a superação de dificuldades.
Aspectos clínicos e epidemiológicos de pacientes internados com sepse em um hospital privado
Authors: Melo Matheus Santos , Seixas Souza Ana Waleska Menezes , Carvalho Thialla Andrade , Andrade Joseilze Santos , Sousa Clara Santana , Rodrigues Iellen Dantas Campos Verdes , Lobo Iza Maria Fraga
Published: July 2021

O objetivo do estudo é descrever as características clínico-epidemiológicas de pacientes internados com sepse, assim como, determinar o uso de drogas vasoativas, antimicrobianos e os principais desfechos nestes pacientes. Trata-se de um estudo descritivo, com abordagem quantitativa, realizado com 367 pacientes internados com diagnóstico de sepse no período de fevereiro de 2016 a julho de 2017 em um hospital privado do estado de Sergipe, Brasil, o qual realiza atendimentos ambulatoriais e de emergência. Após aprovação do Comitê de Ética em Pesquisa, os dados foram coletados por meio dos registros contidos em prontuários por um único pesquisador. A sepse foi responsável por 367 (2,2%) internações no período do estudo, a maioria dos pacientes eram idosos (78,5%), do sexo feminino (50,7%), com pelo menos três comorbidades (70,3%) e internados por sepse clínica (94,5%). A classe de antibióticos mais utilizada foi a dos β-lactâmicos (64,6%). O tempo de permanência e a mortalidade mostraram-se expressivamente maior nos pacientes que sofreram choque séptico em relação aos que não sofreram. O estudo evidenciou que a sepse acometeu majoritariamente idosos do sexo feminino e que as maiores taxas de mortalidade e o maior período de permanência foram observados nos pacientes com agravamento da sepse.
Índice de conicidade e relação cintura quadril na avaliação do risco cardiovascular em idosos
Authors: Maniva Samia Jardelle Costa de Freitas , Nascimento Karleandro  Nascimento Pereira do , Almeida Francisca Érika rodrigues de , Pinheiro Angélica Barreira , Marculino Hertta Hellen Sousa , Gomes Regina Kelly Guimarães , Freitas Consuelo Helena Aires de
Published: July 2021

Objetivo: avaliar o risco cardiovascular de idosos pela Relação Cintura-Quadril e pelo Índice de Conicidade em uma Instituição de Longa Permanência e em um Centro de Convivência para idosos. Método: trata-se de um estudo descritivo, com abordagem quantitativa realizado em uma Instituição de Longa Permanência do Idoso e em um Centro de Convivência para idosos. Compôs-se de uma amostra de vinte e oito idosos e efetuou-se a coleta por meio de um formulário estruturado. Utilizou-se a análise temática dos dados e respeitou-se os aspectos éticos. Resultados: houve predomínio do sexo masculino, com média de idade de 76 anos e 77 anos. A doença crônica mais prevalente foi a hipertensão, seguida pelo diabetes mellitus. Em ambos os locais de estudo a média da relação cintura-quadril foi de 0,94 e 0,92 e o índice de conicidade apresentou uma média de 1,35 e 136, ambos inadequados. Conclusão: constatou-se que a população estudada possui fatores de risco cardiovascular, pois obtiveram medidas de corte acima do recomendado, segundo diretrizes e protocolos vigentes.
Percepção de homens sobre a influência da alimentação no câncer de próstata
Authors: Oliveira Pâmela Scarlatt Durães , Fernandes Queiroz Patricia Sousa , Lima Clara Cynthia Melo , Rocha Rodrigo Marques Batista , Barbosa Henrique Andrade , Vieira Isabella Batista
Published: July 2021

Objetivo: conhecer a percepção do homem sobre a influência da alimentação no câncer de próstata a fim de favorecer a elaboração de ações de prevenção e controle desta doença.

Metodologia: ensaio comunitário realizado com 60 homens cadastrados em uma Estratégia Saúde da Família da cidade de Montes Claros (MG) com faixa etária superior a 40 anos. A coleta de dados ocorreu em três reuniões na forma de grupo focal. A análise de conteúdo temática e os dados foram organizados no software – Atlas Ti.

Resultados: conforme os objetivos desse estudo emergiram uma categoria e três subcategorias temáticas em que são apresentados o significado da interferência da alimentação para o câncer de próstata, em que os homens demonstram pouco conhecimento acerca de alimentos que protegem ou favorecem o surgimento do câncer de próstata; a influência das interações sociais na alimentação, subcategoria que demonstra a relevância do contexto social para adoção de hábitos alimentares saudáveis por parte dos homens  e a importância do profissional de saúde na promoção de hábitos alimentares saudáveis.

Conclusão: os homens entrevistados apresentam conhecimento ainda incipiente sobre a influência da alimentação na prevenção ou favorecimento do surgimento do câncer de próstata. Sugere-se, portanto, que os profissionais nos diferentes espaços de cuidado, orientem a população masculina sobre hábitos alimentares saudáveis, focando nos alimentos que previnem o aparecimento do câncer.
Disconnected Development? The Importance of Specific Human Capital in the Transition From Student Teaching to the Classroom
Authors: Krieg John M. , Goldhaber Dan , Theobald Roddy
Published: July 2021

We use a novel database of student teaching placements in Washington State to investigate teachers’ transitions from student teaching classrooms to first job classrooms and the implications for student achievement. We find first-year teachers are more effective when they teach in the same or an adjacent grade, in the same school type, or in a classroom with student demographics similar to their student teaching classroom. We document that only 27% of first-year teachers are teaching the same grade they student taught, and that first-year teachers tend to begin their careers in higher poverty classrooms than their student teaching placements. This suggests that better aligning student teacher placements with first-year teacher hiring could be a policy lever for improving early-career teacher effectiveness.
RNA-binding protein hnRNPR reduces neuronal cholesterol levels by binding to and suppressing HMGCR
Authors: Agbo John , Akinyemi Akinsola Raphael , Li Dingfeng , Zhang Qingyang , Li Xiaohui , Li Wenbo , Zhang Juan , Liu Qiang
Published: July 2021

Recent studies have identified multiple RNA-binding proteins tightly associated with lipid and neuronal cholesterol metabolism and cardiovascular disorders. However, the role of heterogeneous nuclear ribonucleoprotein R (hnRNPR) in cholesterol metabolism and homeostasis, whether it has a role in regulating 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR), is largely unknown. This research identifies hnRNPR as a repressor of HMGCR. Knockdown and overexpression of hnRNPR in cultured neuroblastoma cell (N2a) and MN1 cell lines enhances and inhibits HMGCR in vitro, respectively. hnRNPR may exert its repressive activity on HMGCR mRNA and protein levels by using its RNA recognition motif (RRM) in recognizing and modulating the stability of HMGCR transcript. Our RNA immunoprecipitation and luciferase reporter assays demonstrate a direct interaction between hnRNPR and HMGCR mRNA. We also demonstrated that hnRNR binds to the 3′ untranslated region (3′ UTR) of HMGCR and reduces its translation, while hnRNPR silencing increases HMGCR expression and cholesterol levels in MN1 and N2a cells. Overexpression of HMGCR significantly restores the decreased cholesterol levels in hnRNPR administered cells. Taken together, we identify hnRNPR as a novel post-transcriptional regulator of HMGCR expression in neuronal cholesterol homeostasis.
Combining reverse end-to-side neurorrhaphy with rapamycin treatment on chronically denervated muscle in rats
Authors: Chen Yijian , Yuan Wanqiong , Zeng Xiaolong , Ma Yuanchen , Zheng Qiujian , Lin Bofu , Li Qingtian
Published: July 2021

This preliminary research determines whether a combination of reverse end-to-side neurorrhaphy and rapamycin treatment achieves a better functional outcome than a single application after prolonged peripheral nerve injury. We found that the tibial nerve function of the reverse end-to-side + rapamycin group recovered better, with a higher tibial function index value, higher amplitude recovery rate, and shorter latency delay rate (P < 0.05). The reverse end-to-side + rapamycin group better protected the gastrocnemius muscle with more forceful contractility, tetanic tension, and a higher myofibril cross-sectional area (P < 0.05). Combining reverse end-to-side neurorrhaphy with rapamycin treatment is a practical approach to promoting the recovery of chronically denervated muscle atrophy after peripheral nerve injury.
Altered spontaneous brain activity patterns in dysthyroid optic neuropathy: a resting-state fMRI study
Authors: Jiang Yi-Ping , Yang Yan-Chang , Tang Li-Ying , Ge Qian-Min , Shi Wen-Qing , Su Ting , Shu Hui-Ye , Pan Yi-Cong , Liang Rong-Bin , Li Qiu-Yu , Shao Yi
Published: July 2021

This research investigates the characteristics of spontaneous brain activity in dysthyroid optic neuropathy patients using the regional homogeneity technique. Sixteen patients with dysthyroid optic neuropathy and 16 thyroid-associated ophthalmopathy patients without dysthyroid optic neuropathy were recruited, matched for weight, height, age, sex, and educational level. All participants underwent resting-state functional nuclear resonance imaging, and the characteristics of spontaneous brain activity were evaluated using the regional homogeneity technique. Each participant in the dysthyroid optic neuropathy group also completed the Hospital Anxiety and Depression scale. Receiver operating characteristic curves were used to compare brain activity between the two groups. Pearson correlation analysis evaluated the relationship between regional homogeneity and clinical manifestations in dysthyroid optic neuropathy patients. In addition, we analyzed the correlation between Hospital Anxiety and Depression scale and regional homogeneity. We found that the regional homogeneity values at the corpus callosum/cingulate gyrus and parietal lobe/middle frontal gyrus significantly decreased in dysthyroid optic neuropathy patients. Regional homogeneity values at the corpus callosum/cingulate gyrus and parietal lobe/middle frontal gyrus were negatively correlated with Hospital Anxiety and Depression scale and disease duration. It was found that the regional homogeneity signal values were significantly lower than in thyroid-associated ophthalmopathy without in dysthyroid optic neuropathy, which may indicate a risk of regional brain dysfunction in dysthyroid optic neuropathy. The results show that regional homogeneity has the potential for early diagnosis and prevent dysthyroid optic neuropathy. In addition, the findings suggest possible mechanisms of dysthyroid optic neuropathy optic nerve injury. They may provide a valuable basis for further research on the pathological mechanisms of dysthyroid optic neuropathy.
Atrioventricular and intraventricular blocks in the setting of acute coronary syndromes: a narrative review
Authors: Schiavone Marco , Sabato Federica , Gobbi Cecilia , Denora Marialessia , Zanchi Lucrezia , Gasperetti Alessio , Forleo Giovanni B.
Published: July 2021

Acute coronary syndromes (ACS) might be complicated by atrioventricular (AV) and intraventricular (IV) blocks in a significant number of cases, and often represent a diagnostic and a therapeutic challenge. These conduction disturbances are predictors of adverse prognosis, with complete AV blocks presenting the most severe outcomes, showing an increased in-hospital mortality. With the advent of emergency percutaneous coronary intervention (PCI) and the end of the thrombolysis era, the incidence of both AV and IV blocks has surely decreased, but their prognosis in this setting still remains a matter of debate. The aim of this review is to evaluate the current knowledge on AV and IV blocks in the AMI setting with or without ST segment elevation.
Ticagrelor: clinical development and future potential
Authors: Sanderson Nicholas C. , Parker William A. E. , Storey Robert F.
Published: July 2021

Platelets participate centrally in atherothrombosis, resulting in vessel occlusion and ischaemia. Consequently, optimisation of antiplatelet regimens has the potential to further reduce the residual burden of morbidity and mortality associated with atherosclerosis. Ticagrelor is a potent oral platelet P2Y12 receptor antagonist that (1) inhibits a central amplification pathway of platelet activation directly as well as via an active metabolite, (2) has a rapid onset and offset of antiplatelet action that remains consistent in the circulation during twice-daily administration and is amenable to reversal, (3) has inverse agonist properties, and (4) demonstrates pleiotropic effects that contribute to anti-thrombotic, anti-inflammatory and vasodilatory properties. These advantageous characteristics of ticagrelor have translated to beneficial clinical outcomes in patients with acute coronary syndromes or ischaemic stroke, during prolonged maintenance therapy in specific high-risk populations, and following percutaneous coronary intervention but not definitively following coronary artery bypass graft surgery or in peripheral artery disease patients. Novel innovative strategies aim to reduce the risk of bleeding during dual antiplatelet therapy via shortening the duration of treatment and replacing the standard-of-care with ticagrelor monotherapy. In cases where aspirin is an essential component in secondary prevention, dose modification when combined with ticagrelor may hypothetically provide desirable clinical outcomes following appropriate clinical assessment as predicted by pharmacological studies. Overall, the future management of acute coronary syndromes could potentially involve the dichotomisation of antithrombotic therapies, whereby only those with high-risk of ischaemia, without a high-risk of bleeding, receive ticagrelor plus very-low-dose aspirin, while ticagrelor monotherapy is administered to the remaining majority.
Left ventricular outflow obstruction occurs immediately after exercise in patients with non-obstructive hypertrophic cardiomyopathy
Authors: Kim Jong-Youn , Choi Eui-Young , Kim Wonho , Rim Se-Joong
Published: July 2021

We evaluated the hemodynamic and geometric determinants of latent obstruction (LO, trans-left ventricular outflow tract (LVOT) gradient ≥30 mmHg with provocation) in patients with non-obstructive hypertrophic cardiomyopathy (HCMP). A total of 35 patients with non-obstructive HCMP underwent stepwise supine bicycle exercise echocardiography. Trans-LVOT pressure gradients, mitral geometric parameters, left ventricular ejection fractions (LVEF) and left ventricular end-systolic and diastolic dimensions (LVESD, LVEDD) were measured at each stage. The highest peak LVOT pressure gradient predominantly occurred immediately after exercise (n = 32, 91.3%) rather than during peak exercise (n = 3, 8.7%). Significant LO developed in nine patients (25%). No significant differences were found in resting echocardiographic parameters. Compared to the remaining patients, however, patients with LO had longer residual mitral leaflets (defined as residual portions of leaflets after coaptation; 4 ± 4 vs. 13 ± 4 mm, respectively; p = 0.001) and higher resting LVOT pressure gradients (7.4 ± 3.7 vs. 12.9 ± 5.8 mmHg, respectively; p = 0.001). Substantial decreases in mitral annular diameters from peak exercise to recovery after exercise were observed in the LO group, while mitral annular diameters increased after exercise in the non-LO group. In conclusion, the highest peak LVOT pressure gradient predominantly occurred immediately after exercise rather than during peak exercise, regardless of LO. Abrupt decrease of mitral annular diameter immediately after exercise, a longer residual mitral leaflet and a higher resting LVOT pressure gradient at rest might be related to LO.
Hematocrit change as a predictor of readmission for decompensated heart failure: a retrospective single centre study
Authors: Zulastri Mohd Aizuddin Mohd , Hafidz Muhammad Imran , Ismail Muhammad Dzafir , Zuhdi Ahmad Syadi Mahmood
Published: July 2021

In patients with acute heart failure (AHF), hemoconcentration has been suggested as a surrogate for volume changes (AHF). However, literatures comparing the outcome of AHF patients that achieved hemoconcentration during hospitalization with those that do not are limited. The aim of this research is to see if achieving hemoconcentration prior to discharge is linked to a lower risk of re-admission in AHF patients. 124 patients hospitalized in the Cardiology Unit, University Malaya Medical Centre (UMMC) for AHF between November 2019 and November 2020 were enrolled. Information on patients’ clinical characteristics, laboratory values and in-hospital treatments were collected through electronic medical record. At admission and discharge, the change in hematocrit (HCT) levels was calculated, and patients were stratified based on two quantiles of delta HCT, either discharged with hemoconcentration (ΔHCT >1.5%) or without hemoconcentration (ΔHCT ≤1.5%). The study’s outcome was AHF readmission after a 90-day follow-up period. Readmission was significantly associated with ejection fraction (p = 0.032) and HCT change (p = 0.005). Consecutively, logistic regression performed revealed that patients with haemoconcentration were 78.3% less likely to be readmitted than those without haemoconcentration (OR = 0.217, p = 0.003, 95% CI = 0.078–0.605) and Patients with a lower ejection fraction have a threefold greater chance of being readmitted than those with a preserved ejection fraction (OR = 3.316, p = 0.022, 95% CI = 1.188–9.256). In conclusion, among patients hospitalized and discharged for AHF, those that (i) do not achieve haemoconcentration and (ii) patients with a reduced ejection fraction were more likely to be readmitted with acute heart failure. Therefore, optimising patients’ haematocrit levels prior to discharge may potentially reduce rehospitalizations among heart failure patients.
Mediating Close Friendship Intimacy in Times of (Social) Distance
Authors: Teichert Jeannine
Published: July 2021

This article presents mediated intimacy in friendships as a necessary but difficult course of action to bridge physical absence between close friends. Following migration research to picture the mediation of intimacy of transnational family members, differences regarding the communicative behaviour, and specifically, the obligation to communicate contrasts distant friendships with translocal family interactions. Drawing on a German study on friendship communication, this paper asks the question how to derivate measures for profound friendship exchange in social distance, with regard to the current COVID-19 pandemic. Findings reveal communication media are definitely useful to keep up existing friendships but they also prevent meaningful friendship interaction. Accordingly, this paper contributes to the discussion of mediated communication and the production of mediated intimacy in friendships and highlights potential prospects to enhance physically distanced friendships.
‘Digital Contemplative Community in Pandemic Times’: Creative Response
Authors: Radeva Katherina
Published: July 2021

Multi-award winning artist Katherina Radeva responds to ‘Digital Contemplative Community in Pandemic Times’
Peretz Markish on the Holocaust in 1942 and in 1947
Authors:   Lomonosov Moscow State University, Polyan Alexandra ,   Universität Regensburg
Published: July 2021

The paper focuses on two Holocaust writings by Peretz Markish: the play An Eye for an Eye (1942) and the magnum opus The March of Generations. The play was later reworked into the first parts of the novel that was written in 1947 and published posthumously in 1966. Two incomplete copies of the play are available at the Russian State Archive of Literature and Arts. From the original Yiddish text, only a few episodes survived, each of them in 2–3 versions. The Russian translation by M.Shambadal is opening episodes and the last page. The article attempts to reconstruct the play’s plot, to analyze its motif structure against the backdrop of Markish’s other Holocaust-related plays, and to trace the transformations it underwent when incorporated into the first part of the novel. Both works also provide us with some historical insights telling what the JAFC members knew about the Holocaust as early as in 1942, and suggesting the hand of the Soviet censorship.
Anti-Jewish Conspiracy Theories in Putin’s Russia
Authors:   University of Leeds, Yablokov Ilya
Published: July 2021

This article considers two cases of antisemitic political rhetoric and explores the nature of anti-Jewish conspiracy theories in Putin’s Russia. The author concludes that anti-Jewish conspiracy theories are a somewhat marginalised intellectual product. Unlike anti-Western conspiracy theories – which are a mainstream driver of political discussions, these are rarely used by the Russian political establishment for the pur-poses of political mobilisation.
Kewenangan Mahkamah Konstitusi terkait kasus kewarganegaraan ganda_154
Authors: Adriani
Published: July 2021

Mahkamah Konstitusi memastikan akan menerima dan memproses gugatan yang dilayangkan pasangan calon nomor urut 1 pada Pilkada Kabupaten sabu raijua Nusa Tenggara Timur. Sebelumnya, paslon nomor urut 1 diwakili Kuasa hukumnya mendatangi MK untuk menyerahkan gugatan sengketa pilkada terkait polemik kewarganegaraan Bupati terpilih Orien Korea meski pendaftaran gugatan sengketa Pemilu sudah terlambat tim kuasa hukum berharap MK dapat mempertimbangkan kasus tersebut mengingat Ada dugaan pelanggaran berat terkait kewarganegaraan Orient yang baru terungkap awal Februari 2021. Mahkamah Konstitusi merupakan salah satu lembaga negara pelaksana kekuasaan kehakiman yang merdeka untuk menyelenggarakan peradilan guna menegakkan hukum dan keadilan Mahkamah Konstitusi Republik Indonesia adalah lembaga tinggi negara dalam sistem ketatanegaraan Indonesia yang merupakan pemegang kekuasaan kehakiman bersama-sama dengan Mahkamah Agung. Kewarganegaraan ganda adalah suatu status yang disematkan kepada seseorang yang secara hukum merupakan Warga Negara saat di beberapa negara kewarganegaraan ganda ada karena sejumlah negara memiliki persyaratan kewarganegaraan yang berbeda dan tidak eksklusif.
Mutmainnah_final_HTN
Authors: Mutmainnah
Published: July 2021

jurnal tentang kewenangan MK dalam pilkada.
Students’ Attitude Towards Studying History and Teaching Practices
Authors: Issar Kriti
Published: July 2021

As an academic subject taught in schools, history provides infinite opportunities to develop analytical skills, value judgment and expression of creativity. But the actual classroom reality tells a different story. The linear approach to history teaching makes the subject extremely dull, monotonous and burdensome to the students. It is this attitude towards history teaching which breeds the perceptions of history being a non-utility subject, having no relevance with the present or future. The present paper synthesizes the findings of an empirical data collected to study the attitude of students towards history and the scope of creativity in history classrooms. The data were collected through classroom observations and questionnaires in three different schools of Delhi. Data analysis highlighted that majority of students did not like studying history or pursuing history as a career choice. Classroom observations found history teaching too much textbook centric and unrelated to students’ experiences. Content loaded and rigid methods of teaching history were the plausible reasons for students possessing negative attitude towards history.
Uma métrica que aproxima os reais ao zero
Authors: Lobo Matheus Pereira
Published: July 2021

Mostramos que existe uma métrica nos reais tal que qualquer número real está mais próximo do zero do que de qualquer outro real.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PRODUKSI INDUSTRI KOPI ROBUSTA DI KECAMATAN WAY TENONG KABUPATEN LAMPUNG BARAT
Authors: Fajri Ratu Chaterine , Alamsyah Robby , Purnomo Agus
Published: July 2021

Menjadi penghasil kopi tertinggi di Indonesia, yakni Provinsi Lampung. Kecamatan Way Tenong yang terdapat di Kabupaten Lampung Barat sebagian besar bermata pencaharian penduduk yaitu sebagian petani. Iklim yang mendukung, dan lahan yang strategis memungkinkan besarnya pertumbuhan di bidang pertanian, spesialnya kopi Robusta. Sebagian besar penduduk Kabupaten Lampung Barat bermata pencaharian selaku pemilik perkebunan kopi. Tipe riset yang digunakan dalam riset ini ialah kuantitatif. Populasi dalam studi ini yakni Petani kopi yang terletak di Kecamatan Way Tenong Lampung Barat, ada pula jumlah ilustrasi yang hendak diteliti sebanyak 40 responden petani kopi. Analisis regresi berganda untuk menganalisis pengaruh modal, tenaga kerja, serta luas lahan berpengaruh terhadap penciptaan industri kopi robusta di Kecamatan Way Tenong Lampung Barat. Hasil perhitungan menampilkan kalau F- hitung dan F- tabel, menunjukkan kalau variabel independen mutlak mempengaruhi hasil terhadap variabel dependen.
TUGAS JURNAL MUH ABRAR
Authors: MUH.ABRAR.L
Published: July 2021

Hak merupakan unsur normatif yang melekat pada diri setiap manusia yang dalam penerapannya berada pada ruang lingkup hak persamaan dan hak kebebasan yang terkait dengan interaksinya antara individu atau dengan instansi. Hak juga merupakan sesuatu yang harus diperoleh. Perlu diingat bahwa dalam hal pemenuhan hak, kita hidup tidak sendiri dan kita hidup bersosialisasi dengan orang lain.
A Tale of Seven Cases – Faculty Unions in the United States – From Yeshiva To Elon: Is It Time to Review Yeshiva and the Positions of Church-Sponsored Colleges and Universities As Well?
Authors: Hunter Richard J. , Lozada Hector R. , Shannon John H.
Published: July 2021

This article is a summary discussion of the main issues faced by faculty at private, often church-sponsored, universities who sought to be represented by a union in collective bargaining with their employers. The discussion begins by tracing the origins of the rule that faculty at private universities are managers and not employees under the aegis of the National Relations Act in the Supreme Court case of Yeshiva University. The summary then follows developments over the years up to the most recent decision of the National Labor Relations Board that sanctioned the efforts of adjunct professors at Elon University to seek union representation. In examining these two book-end cases, the article discusses issues relating to the effect of the religion clauses of the First Amendment in the context of the National Labor Relations Board’s shifting views on the topic. Last, the authors discuss unionization in the context of church-sponsored colleges and universities. Is it now time for the Supreme Court to review its seminal decision in Yeshiva University and for church-sponsored colleges and universities to rethink their positions as well?