bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of CBL family ubiquitin ligases in cancer progression and therapeutic strategies
Authors: Ren Jiaqi , Lv Linlin , Tao Xufeng , Zhai Xiaohan , Chen Xuyang , Yu Hao , Zhao Xinya , Kong Xin , Yu Zhan , Dong Deshi , Liu Jing
Published: July 2024

The CBL (Casitas B-lineage lymphoma) family, as a class of ubiquitin ligases, can regulate signal transduction and activate receptor tyrosine kinases through various tyrosine kinase-dependent pathways. There are three members of the family: c-CBL, CBL-b, and CBL-c. Numerous studies have demonstrated the important role of CBL in various cellular pathways, particularly those involved in the occurrence and progression of cancer, hematopoietic development, and regulation of T cell receptors. Therefore, the purpose of this review is to comprehensively summarize the function and regulatory role of CBL family proteins in different human tumors, as well as the progress of drug research targeting CBL family, so as to provide a broader clinical measurement strategy for the treatment of tumors.
Huanshaodan regulates microglial glucose metabolism reprogramming to alleviate neuroinflammation in AD mice through mTOR/HIF-1α signaling pathway
Authors: Shang Congcong , Su Yunfang , Ma Jinlian , Li Zhonghua , Wang Pan , Ma Huifen , Song Junying , Zhang Zhenqiang
Published: July 2024

Abnormal glucose metabolism in microglial is closely associated with Alzheimer’s disease (AD). Reprogramming of microglial glucose metabolism is centered on regulating the way in which microglial metabolize glucose to alter microglial function. Therefore, reprogramming microglial glucose metabolism is considered as a therapeutic strategy for AD. Huanshaodan (HSD) is a Chinese herbal compound which shows significant efficacy in treating AD, however, the precise mechanism by which HSD treats AD remains unclear. This study is aim to investigate whether HSD exerts anti-AD effects by regulating the metabolic reprogramming of microglial through the mTOR/HIF-1α signaling pathway. SAMP8 mice and BV2 cells were used to explore the alleviative effect of HSD on AD and the molecular mechanism in vivo and in vitro. The pharmacodynamic effects of HSD was evaluated by behavioral tests. The pathological deposition of Aβ in brain of mice was detected by immunohistochemistry. ELISA method was used to measure the activity of HK2 and the expression of PKM2, IL-6 and TNF-α in hippocampus and cortex tissues of mice. Meanwhile, proteins levels of p-mTOR, mTOR, HIF-1α, CD86, Arg1 and IL-1β were detected by Western-blot. LPS-induced BV2 cells were treated with HSD-containing serum. The analysis of the expression profiles of the CD86 and CD206 markers by flow cytometry allows us to distinguish the BV2 polarization. Glucose, lactic acid, ATP, IL-6 and TNF-α levels, as well as lactate dehydrogenase and pyruvate dehydrogenase activities were evaluated in the BV2. Western-blot analysis was employed to detect mTOR, p-mTOR, HIF-1α and IL-1β levels in BV2. And the mTOR agonist MHY1485 (MHY) was chosen to reverse validate. In this study, it is found that HSD improved cognitive impairment in SAMP8 mice and reduced Aβ deposition, suppressed the levels of glycolysis and neuroinflammation in mice. In LPS-induced BV2 cells, HSD also regulated glycolysis and neuroinflammation, and suppressed the mTOR/HIF-1α signaling pathway. More importantly, these effects were reversed by MHY. It is demonstrated that HSD regulated microglial glucose metabolism reprogramming by inhibiting the mTOR/HIF-1α signaling pathway, alleviated neuroinflammation, and exerted anti-AD effects. This study provided scientific evidence for the clinical application of HSD for treating AD.
Unraveling persistent dyspnea after mild COVID: insights from a case series on hyperventilation provocation tests
Authors: Ritter Ophélie , Noureddine Sofia , Laurent Lucie , Roux Pauline , Westeel Virginie , Barnig Cindy
Published: July 2024

Dyspnea is a common yet poorly understood symptom of long COVID, affecting many patients. This brief report examines the role of dysfunctional breathing in persistent dyspnea among patients with mild post-COVID-19 using hyperventilation provocation tests (HVPT). In this case series, six patients with unexplained dyspnea and normal cardiopulmonary function underwent HVPT. Despite normal exercise testing results, all patients exhibited delayed PETCO2 recovery, indicative of a hyperventilation pattern consistent with chronic hyperventilation syndrome, without typical symptomatic manifestations. These findings suggest underlying post-COVID respiratory dysregulation, emphasizing the importance of targeted diagnostic and therapeutic approaches for persistent respiratory symptoms in long COVID patients.
Breeding for improved digestibility and processing of lignocellulosic biomass in Zea mays
Authors: Vanhevel Yasmine , De Moor Astrid , Muylle Hilde , Vanholme Ruben , Boerjan Wout
Published: July 2024

Forage maize is a versatile crop extensively utilized for animal nutrition in agriculture and holds promise as a valuable resource for the production of fermentable sugars in the biorefinery sector. Within this context, the carbohydrate fraction of the lignocellulosic biomass undergoes deconstruction during ruminal digestion and the saccharification process. However, the cell wall’s natural resistance towards enzymatic degradation poses a significant challenge during both processes. This so-called biomass recalcitrance is primarily attributed to the presence of lignin and ferulates in the cell walls. Consequently, maize varieties with a reduced lignin or ferulate content or an altered lignin composition can have important beneficial effects on cell wall digestibility. Considerable efforts in genetic improvement have been dedicated towards enhancing cell wall digestibility, benefiting agriculture, the biorefinery sector and the environment. In part I of this paper, we review conventional and advanced breeding methods used in the genetic improvement of maize germplasm. In part II, we zoom in on maize mutants with altered lignin for improved digestibility and biomass processing.
Factors associated with contemporary fatherhood
Authors: Hershkovitz-Freudenthal Adi , Lavenda Osnat
Published: July 2024

Introduction

The most prevalent conceptualization of parenting of our time is intensive parenting which refers to parents’ overinvolvement in children’s lives, placing the child’s needs before others’ needs, including the needs of the parents themselves (i.e., Child-centrism). Intensive parenting is mostly attributed to mothers as they are still bearing the bulk responsibility for child rearing. Nevertheless, as the role of fathers changed in recent decades it is crucial to examine intensive parenting among fathers and understand whether factors that are associated with intensive mothering are associated with intensive fatherhood as well. The current study uses Belsky’s Process of Parenting model to fill-in the gap.

Methods

Participants were 301 Israeli fathers of preschool children aged 22 to 50 years old (M=36.34, SD=5.01). They filled out online self-report questionnaires dealing with intensive parenting style, child temperament, social support, marital satisfaction, and parental self-efficacy.

Results

The model explained 64% of paternal child-centrism. Fathers who reported having children with more difficult temperament, reported low social support, low marital satisfaction, and low self-efficacy, were more intensive in their parenting style.

Discussion

The present findings are discussed in relation to previous findings regarding maternal child-centrism with an emphasis on their important implications for professionals working with families for the benefit of parents’ and children’s wellbeing.
Obstructive sleep apnea and 19 gastrointestinal diseases: a Mendelian randomization study
Authors: Yan Weiheng , Zhou Jiayi , Jiang Miaomiao , Kong Yaru , Qin Han , Qi Yuwei , Wang Shan , Tai Jun
Published: July 2024

Background

Alterations gastrointestinal diseases (GDs) were reported in individuals with obstructive sleep apnea (OSA), however, the genetic background between OSA and GDs is still unclear.

Methods

This investigation employed Mendelian randomization (MR) analyses to evaluate the causal effect between OSA and 19 types of GDs (gastroesophageal reflux disease (GERD), ulcerative colitis, celiac disease, Crohn’s disease, chronic gastritis, irritable bowel syndrome, primary biliary cholangitis, diverticular disease, gastroduodenal ulcer, acute pancreatitis, non-alcoholic fatty liver disease, primary sclerosing cholangitis, cirrhosis, calculus of bile duct, calculus of gallbladder, pancreatic cancer, gastric cancer, colorectal cancer, and esophageal cancer). The inverse-variance weighted (IVW) method was used to evaluate the main effects model of causality.

Results

This MR study suggests that OSA may play a causal role inflammation-related GDs (GERD, PIVW=5.94×10-9; gastroduodenal ulcer, PIVW=1×10-4; chronic gastritis, PIVW=0.0214; ulcerative colitis, PIVW=0.0296), and gallstones (calculi of the gallbladder, PIVW=0.0429; calculi of the bile duct, PIVW=0.0068). After accounting for obesity, type 2 diabetes, smoking, and alcohol consumption, the multivariate MR (MVMR) analysis identified that OSA is an independent risk factor for GERD, gastroduodenal ulcer, and calculus of the bile duct. The reverse MVMR analysis showed a causal effect of GERD on OSA. Besides, we did not find that the predisposition to OSA was associated with 4 cancers.

Conclusion

This MR analysis provides compelling evidence of an independent causal relationship between genetically predicted OSA and an elevated risk of inflammation-related GDs. Besides, no causal association was observed between OSA and cancers. Further studies should be carried out to verify our findings.
Case report: Down syndrome regression disorder, catatonia, and psychiatric and immunomodulatory interventions
Authors: Connors Michael H. , Sachdev Perminder S. , Colebatch James G. , Taylor Mark S. , Trollor Julian , Mohan Adith
Published: July 2024

Down syndrome regression disorder (DSRD) is a rare condition involving subacute cognitive decline, loss of previously acquired developmental skills, and prominent neuropsychiatric symptoms, particularly catatonia, in people with Down syndrome. It is thought to involve both autoimmune and neuropsychiatric mechanisms. Research, however, is largely restricted to case studies and retrospective case series and is particularly limited in terms of prospective longitudinal follow-up. We report a case study of a person with DSRD who received both immunomodulatory (intravenous immunoglobulin; IVIG) and psychiatric interventions (electroconvulsive therapy, ECT) over two years with regular assessments using caregiver and clinician ratings. This revealed a small, unsustained response to IVIG and a rapid, sustained response once ECT was introduced. The case highlights the importance of multimodal assessment involving multiple medical specialties, the need to trial different therapies due to the condition’s complexity, and the significant barriers that patients and their families face in accessing care.
Public perceptions and discussions of synthetic nicotine on Twitter
Authors: Chen Jiarui , He Jinxi , Xie Zidian , Li Dongmei
Published: July 2024

Background

As alternative replacement products for tobacco-derived nicotine, synthetic nicotine products have recently emerged and gained increasing popularity. This study analyzes public perception and discussion of synthetic nicotine products on Twitter (now “X”).

Methods

Through Twitter streaming API (Application Programming Interface), we have collected 2,764 Twitter posts related to synthetic nicotine from December 12, 2021, to October 17, 2022, using keywords related to synthetic nicotine. By applying an inductive approach, two research assistants manually determined the relevance of tweets to synthetic nicotine products and assessed the attitude of tweets as positive, negative, and neutral of tweets toward synthetic nicotine, and the main topics.

Results

Among 1,007 tweets related to synthetic nicotine products, the proportion of negative tweets (383/1007, 38.03%) toward synthetic nicotine products was significantly higher than that of positive tweets (218/1007, 21.65%) with a p-value <0.05. Among negative tweets, major topics include the concern about addiction and health risks of synthetic nicotine products (44.91%) and synthetic nicotine as a policy loophole (31.85%). Among positive tweets, top topics include alternative replacement for nicotine (39.91%) and reduced health risks (31.19%).

Conclusion

There are mixed attitudes toward synthetic nicotine products on Twitter, resulting from different perspectives. Future research could incorporate demographic information to understand the attitudes of various population groups.
Construction of a predictive nomogram for functional recovery after Bernese periacetabular osteotomy
Authors: Du Panzhihao , Gu Yange , Jin Wenshu , Li Shufeng , Yue Yaohui , Sun Huaqiang , Yan Xinfeng
Published: July 2024

Background and purpose

Surgical indications for Bernese periacetabular osteotomy (PAO) are well-established. However, the extent of postoperative functional recovery varies widely, as observed in clinical follow-ups. Thus, preoperative evaluation is crucial. This study aims to identify factors that influence functional recovery post-PAO and to develop a predictive nomogram.

Patients and methods

Retrospective data were collected between December 2016 and March 2022 at The First Affiliated Hospital of Shandong First Medical University. The dataset included demographic and imaging data of patients who underwent PAO. The least absolute shrinkage and selection operator (LASSO) regression was utilized to identify influencing factors, which were further analyzed using multivariate logistic regression to construct a predictive nomogram for post-PAO functional recovery.

Result

The analysis identified critical factors affecting functional recovery post-PAO, namely, the preoperative distance from the innermost surface of the femoral head to the ilioischial line, the surgical approach, preoperative acetabular depth, and the continuity of the preoperative Calve line. A nomogram was developed using these significant predictors. The model's validity was demonstrated by the receiver operating characteristic curve, with an area under the curve of 0.864. Additionally, the calibration curve confirmed the nomogram's accuracy, showing a strong correlation between observed and predicted probabilities, indicating high predictive accuracy.

Conclusion

This predictive nomogram effectively identifies patients most suitable for PAO, providing valuable guidance for selecting surgical candidates and determining the appropriate surgical approach.
Characterization of the adaptive cellular and humoral immune responses to persistent colonization of Brucella abortus strain RB51 in a Jersey cow
Authors: Boggiatto Paola M. , Sterle Haley , Falkenberg Shollie , Sarlo-Davila Kaitlyn , Putz Ellie J. , Olsen Steven C.
Published: July 2024

Brucella abortus strain RB51 is the commercial cattle vaccine used in the United States (US) and many parts of the world against bovine brucellosis. RB51 was licensed for use in 1996, and it has been shown to be safe and efficacious in cattle, eliciting humoral and cellular responses in calves and adult animals. In 2017, an epidemiological trace-back investigation performed by the Centers for Disease Control and Prevention (CDC) identified human cases of brucellosis caused by infection with RB51. These infections resulted from the consumption of unpasteurized dairy products, which were traced back to otherwise healthy animals that were shedding RB51 in their milk. At the current time, six adult Jersey cows have been identified in the U.S. that are shedding RB51 in milk. One of the RB51 shedding cattle was obtained and housed at the National Animal Disease Center (NADC) for further study. Improved understanding of host cellular and humoral immune responses to RB51 in persistently colonized cattle may be achieved by the characterization of responses in shedding animals. We hypothesized, based on the lack of RB51 clearance, that the RB51 shedder animal has a diminished adaptive cellular immune response to RB51. Our data demonstrate that in the presence of persistent RB51 infection, there is a lack of peripheral anti-RB51 CD4+ T cell responses and a concurrently high anti-RB51 IgG humoral response. By understanding the mechanisms that result in RB51 persistence, the development of improved interventions or vaccinations for brucellosis may be facilitated, which would provide public health benefits, including reducing the risks associated with the consumption of non-pasteurized milk products.
Exploring the reticulo-ruminal motility pattern in goats through medical barium meal imaging technology
Authors: Song Yang , Lan Xinyi , Liu Lei , Wan Fachun , Shen Weijun , Wang Zuo
Published: July 2024

The motility pattern of the reticulo-rumen is a key factor affecting feed intake, rumen digesta residence time, and rumen fermentation. However, it is difficult to study reticulo-ruminal motility using general methods owing to the complexity of the reticulo-ruminal structure. Thus, we aimed to develop a technique to demonstrate the reticulo-ruminal motility pattern in static goats. Six Xiangdong black goats (half bucks and half does, body weight 29.5 ± 1.0 kg) were used as model specimens. Reticulo-ruminal motility videos were obtained using medical barium meal imaging technology. Videos were then analyzed using image annotation and the centroid method. The results showed that reticulo-ruminal motility was divided into primary (stages I, II, III, and IV) and secondary contraction, and the movements of ruminal digesta depended on reticulo-ruminal motility. Our results indicated common motility between the ruminal dorsal sac and ruminal dorsal blind sac. We observed that stages I (3.92 vs. 3.21 s) (P < 0.01), II (4.81 vs. 4.23 s) (P < 0.01), and III (5.65 vs. 5.15 s) (P < 0.05); interval (53.79 vs. 50.95 s); secondary contraction time (10.5 vs. 10 s); and were longer, whereas stage IV appeared to be shorter in the bucks than in the does (7.83 vs. 14.67 s) (P < 0.01). The feasibility of using barium meal imaging technology for assessing reticulo-ruminal and digesta motility was verified in our study. We determined the duration of each stage of reticulo-ruminal motility and collected data on the duration and interval of each stage of ruminal motility in goats. This research provides new insights for the study of gastrointestinal motility and lays a solid foundation for the study of artificial rumen.
Measurement of compassion fatigue in animal health care professionals: a systematic review of available instruments and their content validity
Authors: Noe May Thet Nu , Baysal Yigit , Masserey Anaïs , Hartnack Sonja , Guseva Canu Irina
Published: July 2024

Introduction

Compassion fatigue (CF) refers to emotional or physical exhaustion and emotional reactions resulting from prolonged exposure to traumatic events, commonly experienced by professionals in caregiving roles. CF is prevalent among healthcare professionals, including those in animal care. Several Patient-Reported Outcome Measures (PROMs) were developed to measure CF, but their psychometric validity was not reviewed systematically. This study aims to identify and review the content validity of CF PROMs used in animal health care professionals.

Methods

Literature was searched in PubMed, PsycINFO, and EMBASE (1973–2023). We included studies conducted in animal health care professionals, using a PROM to measure CF, reporting at least one psychometric property of this PROM, and published as original research. For each identified PROM, additional literature search was conducted to identify PROM development and content validation studies. Three independent reviewers evaluated the content validity of each PROM using COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology and summarized the quality of evidence using a modified GRADE approach. The protocol was registered in PROSPERO (CRD42023433982) and results reported following PRISMA guidelines.

Results

Initially, 1709 studies were identified. After a double screening, 17 eligible studies were included. CF was measured using six different PROMs or their modified versions. Only one PROM specifically targeted animal health care professionals: the ProQOL-5 Veterinary Medicine Version. This and three other original CF PROMs were reviewed. For all PROMs, the quality of content validity was rated as insufficient due to deficiencies in the concept and items elicitation, inadequate target population representation, and inadequate details on cognitive interview procedures. The overall evidence quality was rated as low due to a limited number of PROM validation studies, poor methodological and reporting quality, and indirect result.

Discussion

There is a scarcity of studies examining CF within the target population, and the quality of evidence for content validity of the reviewed PROMs for CF measurement is currently low. CF definition and construct description in PROM development studies suffer from vagueness and seem inadequately reflected by the content of the reviewed PROMs. Further research with a robust methodology seems necessary to address the identified flows.

Systematic review registration

Measurement of compassion fatigue in people working with animals: protocol for a systematic review. PROSPERO 2023 CRD42023433982. Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023433982.
Diagnoza logopedyczna dziecka z zaburzeniami w rozwoju mowy i języka uwarunkowanymi padaczką. Studium przypadku
Authors: Kurowska Marlena
Published: July 2024

In this study, I present the process of speech therapy diagnosis carried out in a nine-year-old boy with Landau-Kleff ner epilepsy syndrome. The diagnosis was aimed at identifying any abnormalities observed in the child. The actions taken were clinical in nature. They consisted primarily in recording the child’s characteristic verbal and non-linguistic behaviours, and establishing the biopsychological basis for the development of his speech. The tests carried out took the form of a comprehensive study and were described qualitatively. In the process of specifying the diagnosis, an attempt was also made to assess the child’s level of language competence quantitatively using the Language Development Test (TRJ). The results obtained paved the way for a reflection on the tools used in diagnosis.
Badanie umiejętności nazywania emocji przez dzieci jako wyzwanie dla logopedy
Authors: Sadowska Elżbieta
Published: July 2024

Research focused on the human emotional sphere is primarily carried out by psychologists. However, evaluating emotion naming competence is an interdisciplinary issue, and it is vital also for speech therapy. Researchers have observed that many children with neurodevelopmental disorders, e.g., autism spectrum disorder (ASD), experience difficulties in recognising and understanding emotions, as well as naming them. The latter is also challenging for many neurotypical children. Nonetheless, linguistic studies into emotion naming competence are still insufficiently undertaken. The objective of this paper is to present problems encountered while constructing tasks that assess the level of proficiency in emotion naming under test conditions. It also offers preliminary results of a pilot study involving neurotypical kindergarten children. The paper constitutes part of a more extensive research project on the naming and expression of emotions in children with ASD.
Ocena wybranej terminologii logopedycznej w świetle badań ankietowych przeprowadzonych wśród studentów logopedii oraz logopedów praktyków
Authors: Zawadka Joanna , Karsznia-Sobczak Alicja
Published: July 2024

The article presents the results of research on speech therapy terminology. The analysis covered 33 terms, the frequency of which was assessed as low. The main research questions were: “Are the selected speech therapy terms familiar to: a. speech therapy students, b. speech therapists-practitioners?”. “Have a. students, b. therapists been acquainted with dictionary definitions of selected speech therapy terms?”. To answer the research questions, a survey was conducted. It included quesƟtions about the knowledge and understanding of the terms. The results suggest the need for a more detailed description of speech therapy terminology due to not only the varying levels of its familiarity, but also its timeliness and pervasiveness
Numerical Simulation Study of Built-In Porous Obstacles to Improve the Thermal Stratification Performance of Storage Tanks
Authors: Tan Jun , He Shiping , Du Zhenglong
Published: July 2024

Thermocline storage tanks are critical components in energy storage systems for solar renewable energy utilization. The use of thermal stratification of the working fluid within the storage tank for energy storage is a pivotal technology in these systems. Effective thermal stratification can significantly enhance energy storage efficiency, meet a broader range of user demands, and improve the overall performance of the storage tank. Therefore, enhancing the energy storage efficiency of storage tanks is an essential objective. To promote internal temperature stratification within the tank, this study introduces a porous obstacle designed to improve the tank’s internal structure. A comparative analysis was conducted with tanks featuring different structural configurations. Using the commercial finite element software ANSYS, an unsteady Computational Fluid Dynamics (CFD) model was formulated to simulate the energy discharge process of five different tank structures under various operating conditions. By analyzing the internal temperature distribution, thermocline thickness, dimensionless exergy efficiency, and flow field trajectories, the stratification characteristics were determined. The results indicate that the porous obstacle significantly enhances stratification compared to the perforated plate obstacle. At a flow rate of 0.3 m/s, the thermocline thickness in traditional tanks and tanks with perforated plate obstacles is 42% and 14.3% greater, respectively, than in tanks with porous obstacles. Additionally, the study demonstrates that temperature stratification is more pronounced when the porous obstacle is positioned closer to the tank’s bottom, with the optimal configuration being the placement of porous obstacles near both the top and bottom of the tank. At a flow rate of 0.3 m/s, the thermocline thickness in tanks with porous obstacles only at the bottom and middle is 17% and 133% greater, respectively, than in tanks with porous obstacles at both the top and bottom.
Enhancing the Photoelectrochemical Performance of a Superlattice p–n Heterojunction CuFe2O4/ZnFe2O4 Electrode for Hydrogen Production
Authors: Al Turkestani M. K.
Published: July 2024

A p–n heterojunction film consisting of p-type CuFe2O4 and n-type ZnFe2O4 was fabricated in this study. The n-type ZnFe2O4 film was deposited on a stainless steel substrate using the spray pyrolysis method, after which a top layer of p-type CuFe2O4 thin film was deposited and annealed. Characterization techniques, such as X-ray diffraction, scanning electron microscopy, UV–Vis diffuse reflectance spectroscopy, and photoluminescence, confirmed the formation of a superlattice p–n heterojunction between CuFe2O4 and ZnFe2O4. Photoelectrochemical measurements were conducted to investigate the photoelectrochemical properties of the samples, resulting in a photocurrent of 1.2 mA/cm2 at 1.5 V (vs. Ag/AgCl) under illumination from a 100-watt LED light source. Utilizing the p–n junction of CuFe2O4/ZnFe2O4 as a photoanode increased the hydrogen production rate by 30% compared to that of the dark measurement. This enhancement in performance was attributed to the potential barrier at the p–n heterojunction interface, which improved the separation of photoinduced electron–hole pairs and facilitated a more efficient charge transfer. Additionally, coating the stainless steel electrode with this ferrite sample improved both the corrosion resistance and the stability of hydrogen production over extended operation times.
Effects of 60 versus 30 Minutes of Pilates Exercise on Cervicothoracic Alignment, Muscle Strength, and Endurance in University Students with Upper Crossed Syndrome
Authors: Mun Woo-Lim , Roh Su-Yeon
Published: July 2024

Background/Objectives: This study determined the effects of 60 min or 30 min Pilates program on cervicothoracic alignment, muscular strength, and endurance in university students with upper-crossed syndrome (UCS). Methods: Twenty-six university students with UCS were randomly allocated into 60 min Pilates (60 PG, n = 9), 30 min Pilates (30 PG, n = 9), and control (CG, n = 8) groups. The 60 and 30 PG students participated in the Pilates program, focusing on relaxation, stability, mobility, and strengthening of the cervical, thoracic, and scapular muscles for 60 or 30 min per session, twice a week, for 12 weeks. Cervicothoracic alignment was measured using BodyStyle to determine craniovertebral angle (CVA), forward shoulder angle (FSA), head position angle (HPA), head tilt angle (HTA), and kyphosis angle (KA). We measured the muscular strength and endurance of the shoulder on the dominant side. Results: After the intervention, CVA, HPA, HTA, and KA significantly improved in the 60 and 30 PG (all p < 0.01) but not in the CG (p > 0.05). There were no significant differences between the 60 and 30 PG at 4, 8, and 12 weeks. Shoulder strength differed between shoulder flexion and horizontal abduction (p < 0.01). Shoulder endurance differed between extension, flexion, and horizontal abduction (p < 0.05, p < 0.01, and p < 0.001, respectively). Conclusions: This study confirmed the effectiveness of the Pilates program in improving cervicothoracic sagittal alignment and shoulder muscular function in university students with UCS. Additionally, the effects of participating in 60 and 30 min Pilates programs were found to be equivalent. Therefore, encouraging busy university students to participate in at least 30 min of the Pilates program is important.
On the Injectivity of Euler Integral Transforms with Hyperplanes and Quadric Hypersurfaces
Authors: Ji Mattie
Published: July 2024

The Euler characteristic transform (ECT) is an integral transform used widely in topological data analysis. Previous efforts by Curry et al. and Ghrist et al. have independently shown that the ECT is injective on all compact definable sets. In this work, we first study the injectivity of the ECT on definable sets that are not necessarily compact and prove a complete classification of constructible functions that the Euler characteristic transform is not injective on. We then introduce the quadric Euler characteristic transform (QECT) as a natural generalization of the ECT by detecting definable shapes with quadric hypersurfaces rather than hyperplanes. We also discuss some criteria for the injectivity of QECT.
Perceiving God: The Spiritual Senses in Bonaventure’s Mystical Theology
Authors: Puskás Attila
Published: July 2024

This essay examines the distinctive features; unchanging basic elements and changing emphases of Bonaventure’s interpretation of the spiritual senses based on four works selected from different periods of his life and considered significant for the subject. In the first chapter, I analyse the relevant passages of Bonaventure’s Commentary on the Book of Sentences; in the second the De reductione artium ad theologiam; in the third the Breviloquium; and in the fourth the Itinerarium mentis in Deum. The objects of investigation are as follows: the correlation between the acts of spiritual senses and their object; the basis of the hierarchical order of spiritual senses; the relationship between spiritual senses; mental excesses and mystical transit; and the relation to Dionysian mystical theology.
Comunicação de notícias difíceis em Enfermagem oncológica: implicações na relação interpessoal com o binômio paciente-família
Authors: Dias Renata da Silva , Da Silva Thiago Augusto Soares Monteiro
Published: July 2024

Ojetivo: mapear as produções científicas acerca dos desafios e possibilidades inerentes à comunicação de notícias difíceis entre enfermeiros e o binômio paciente-família no contexto da oncologia. Metodologia: trata-se de uma revisão integrativa, realizada em bases de dados com os descritores e palavras-chaves selecionados, posteriormente realizou-se a identificação das publicações, seleção, extração e inclusão dos dados. Resultados: identificou-se 745 resultados, que após análise dos critérios de elegibilidade foram incluídos 10 estudos. Quanto a característica das publicações, identificou-se que cinco são de origem brasileira e que os estudos foram publicados entre 2017 e 2022. Os achados categorizados como barreiras são diferentes naturezas, sendo a fragilidade na formação e preparo do profissional sobre o tema. Conclusão: a comunicação entre os enfermeiros e o binômio paciente-família é permeado por inúmeras questões, principalmente pela falta de treinamento e preparo do profissional, sendo este ponto o mais aconselhado a ser trabalha.
ABSTRACT
Objective: to map scientific productions about the challenges and possibilities inherent to communicating difficult news between nurses and patient-family in the context of oncology. Methodology: this is an integrative review, carried out in databases with the selected descriptors and keywords. Subsequently, studies, selection, extraction and inclusion of data were identified. Results: we identified 745 results, and, after analyzing the eligibility criteria, ten studies were included. Regarding study characteristics, it was identified that five are of Brazilian origin and that studies were published between 2017 and 2022. The findings categorized as barriers are of different natures, such as weaknesses in professional training and preparedness on the topic. Conclusion: the communication between nurses and patient-family is permeated by numerous issues, mainly due to the lack of professional training and preparedness, and this point is the most advisable to be worked on.
Desafios e perspectivas na implementação da Política Nacional de Atenção Integral à Saúde do Homem
Authors: Silva Bárbara Fabrícia , Alves Girlene da Silva
Published: July 2024

Objetivo: Analisar a implementação da Política Nacional de Atenção Integral à Saúde do Homem, no município de Juiz de Fora, Minas Gerais. Metodologia: Trata-se de um estudo de natureza qualitativa. Participaram 33 gerentes das Unidades Básicas de Saúde, através de uma entrevista semiestruturada. O método de análise temática proposto por Bardin foi selecionado para o tratamento dos depoimentos. Resultados: Os achados foram organizados na categoria Atenção Primária à Saúde: desafios e perspectivas na implementação da Política Nacional de Atenção Integral à Saúde do Homem, que contemplou a invisibilidade da política de saúde do homem, bem como a organização da atenção básica para incorporar a referida política no sistema. Considerações finais: Percebeu-se que não basta, somente, a existência de um programa específico com propostas abrangentes de atendimento à saúde do homem, mas é preciso compreender e ajustar os caminhos e os desafios presentes nos locais onde as ações devem ser implementadas.
ABSTRACT
Objective: To analyze the implementation of the National Policy for Integral Attention to Men's Health, in the city of Juiz de Fora, Minas Gerais. Methodology: This is a qualitative study. 33 managers of Basic Health Units participated, through a semi-structured interview. The thematic analysis method proposed by Bardin was selected for the treatment of the testimonies. Results: The findings were organized in the Primary Health Care category: challenges and perspectives in the implementation of the National Policy for Comprehensive Men's Health Care, which included the invisibility of the men's health policy, as well as the organization of primary care to incorporate the referred policy in the system. Final considerations: It was noticed that the existence of a specific program with comprehensive proposals for men's health care is not enough, but it is necessary to understand and adjust the ways and challenges present in the places where the actions must be implemented
DNA profiles of shed Taiga Bean Goose feathers indicate between-season fidelity to moulting sites in Swedish Lapland
Authors: De Jong Adriaan , Kleven Oddmund , Honka Johanna , Vahlström Isak
Published: July 2024

Recently, the Taiga Bean Goose Anser f. fabalis breeding population of Southern Lapland, Sweden, was shown to use a network of local sites during their summer wing moult. We used microsatellite markers to identify individual geese from DNA in shed feathers collected in 2016–2020 on six sites, enabling us to identify 168 unique individuals from 178 fully genotyped feathers. Nine individuals were represented multiple times among the collected feathers. All controls of identified individuals were made on the original site, never on an alternative site. Our results suggest a significant level of site fidelity and, thus, the need to provide a stable, low-disturbance network of moulting sites for the Southern Lapland sub-population of this endangered taxon.
Поиск белковых биомаркеров при атеросклерозе с помощью протеомных технологий - как перспективное направление науки
Authors: Жетишева Р.А. , Ковалева М.А. , Каменихина И.А. , Ковалев Л.И. , Наумов В.Г.
Published: July 2024

В обзоре представлен анализ литературных данных о роли протеомики в патогенезе атеросклероза и о потенциальных биомаркерах заболеваний, с ним ассоциированных. Атеросклероз является основной причиной сердечно-сосудистых заболеваний (ССЗ) во всем мире. Изучение молекулярных механизмов развития и прогрессирования атеросклероза с выявлением его биомаркеров - перспективное направление клинической медицины. С этой целью используют протеомный анализ биологических жидкостей и атеросклеротической ткани. Заключение: Современные протеомные технологии позволяют понять молекулярные механизмы патогенеза атеросклероза, дают возможность выявить новые диагностические и прогностические биомаркеры развития и прогрессирования атеросклероза, что может быть использовано в разработке принципиально новых методов профилактики и лечения
Роль интраабдоминальной жировой ткани в развитии коморбидной кардиальной патологии у пациентов с избыточной массой тела и ожирением
Authors: Логачева И.В. , Рязанова Т.А. , Макарова В.Р.
Published: July 2024

Абстракт Цель. Оценить значение интраабдоминального жирового депо и изучить его взаимосвязь с параметрами ремоделирования сердца и морфометрическими показателями печени у коморбидных кардиологических больных. Материалы и методы. Обследовано 112 пациентов мужского пола с ишемической болезнью сердца (ИБС) и артериальной гипертензией (АГ) в возрасте 61,21,7 года. В зависимости от индекса массы тела (ИМТ) пациенты распределены на три подгруппы: первая 29 человек с ИМТ до 24,9 кг/м2, вторая 43 человека с ИМТ от 25 кг/м2 до 29,9 кг/м2 (избыточный вес), третья 40 человек с ИМТ30 кг/м2 (ожирение III степени). Исследовали антропометрические и метаболические показатели, с помощью ультразвукового аппарата определяли толщину интраабдоминального жира (ТИЖ). На основании Эхо- и доплер-Эхокардиографии (ЭхоКГ) оценивались линейные и объемные параметры левого желудочка и предсердия. Для диагностики неалкогольной жировой болезни печени (НАЖБП) (на стадии стеатоза) выполнялось УЗИ гепатобилиарной системы с оценкой морфометрических и качественных показателей печени. Результаты. Наибольшая величина интраабдоминального жира определялась у больных с избыточной массой тела и ожирением (2 и 3 группы). Установлены положительные корреляции ТИЖ с основными метаболическими показателями (липидным и углеводным спектром, индексом адипозопатии). Результаты исследования выявили корреляцию между ТИЖ - индексом массы миокарда во 2 и 3 группах больных, конечным диастолическим объемом, объемом левого предсердия (p0,001). Установлена взаимосвязь между балльными значениями УЗИ-печени и ТИЖ у тучных больных (r20,59 p0,001 и r30,59 p0,001), а также - наличие прямой корреляции между ТИЖ и увеличением размеров правой и левой доли печени. На основании факторного анализа подтверждена прямая связь НАЖБП (на стадии стеатоза) с основными факторами метаболизма, структурной перестройкой сердца, а также - с величиной ТИЖ. Заключение. У больных ИБС и АГ с избыточной массой тела и ожирением (при исходно равноценном коморбидном статусе) интраабдоминальный жир выступает в качестве дополнительного эктопического висцерального маркера и демонстрирует прямые ассоциации с параметрами углеводного, жирового обмена, параметрами ремоделирования сердца и печени.
Таутомерные формы магния оротата в коррекции магниевого дефицита и липидного статуса у магнийдефицитных животных
Authors: Чучкова Н.Н. , Сметанина М.В. , Кормилина Н.В. , Пазиненко К.А. , Канунникова О.М.
Published: July 2024

Цель исследования: сравнительная оценка терапевтического эффекта таутомеров магния оротата оксо- и гидрокси-форм в коррекции магниевого дефицита и липидного статуса у магнийдефицитных животных. Материал и методы. У животных формировали лекарственно-обусловленный дефицит магния (введение фуросемида 30 мг/кг 14 дней), затем крысы получали оксо-форму (Magnerot, Верваг Фарма ГмбХ и Ко, Германия) и гидрокси-форму магния оротата (МО), полученную методом механоактивации. В крови анализировали уровни магния, кальция и натрия, рассчитывали скорость компенсации магния, оценивали липидный статус (триглицериды, общий холестерин, липопротеиды низкой, очень низкой и высокой плотности), вычисляли индекс атерогенности. Результаты. При введении гидрокси-формы МО в отличие от оксо-формы, скорость компенсации магниевого дефицита выше (на 14 день составляет 29,2 при оксо- и 77,8 при гидрокси-форме МО), восстанавливается соотношение Ca/Mg. Положительная динамика показателей липидного обмена в сравнении с магнийдефицитными животными отмечается на 14 день введения препаратов магния оротата в обеих группах экспериментальных животных, однако, у крыс с введением оксо-формы уровни общего холестерина (на 13,68, р0,05) и холестерина ЛПНП (в 1,28 раз, р0,05) остаются выше исходных показателей, тогда как в группе с введением гидрокси-формы МО результаты сопоставимы с данными интактного контроля. Различия в уровнях ХС ЛПНП между экспериментальными группами на этом сроке введения препаратов составляют 25,66. Коэффициент атерогенности, рассчитываемый на основе полученных данных, возвращается к исходным показателям в группе, получавшей механомодифицированный магний оротат (гидрокси-форма) и остается повышенным (на 26,14) у животных, получавших исходную оксо-форму препарата. Выводы. Гидрокси-форма магния оротата, полученная методом механоактивации исходного препарата Магнерот проявляет более выраженную биологическую (терапевтическую) активность, что проявляется в опережающем восстановлении уровней магния в крови, скорости компенсации дефицита магния, восстановлении соотношения Mg/Ca, нормализации уровня триглицеридов и холестерина ЛПНП, выравнивании коэффициента атерогенности.
Organizational and Management Innovations, Their Formalization and Effectiveness in Large Oil and Gas Corporations
Authors: Боржеш Ажеу Малундо
Published: July 2024

В статье мы рассматриваем результативности организационно-управленческих инноваций (ОУИ) в нефтегазовых корпорациях при соблюдении критериев оптимальности. Обоснованы критерии оптимальности внедрения ОУИ и разработана система показателей оценки ОУИ на основе критериев оптимальности. Разработан методический подход к оценке результативности ОУИ на основе анализа системы критериев и показателей оценки механизма управления инновационной деятельностью.

In the article, we consider the effectiveness of organizational and management innovations (OMI) in oil and gas corporations while observing the optimality criteria. The optimality criteria of OMI implementation are substantiated and a system of indicators is developed for evaluating the OMI on the basis of the optimality criteria. A methodical approach has been developed for evaluating the effectiveness of an OMI based on an analysis of the criteria and indicators system of assessment of the innovation activity management mechanism.
Methodological Tools for Assessing the Probability of Bankruptcy of a Construction Company
Authors: Гайфуллина Марина Михайловна , Низамова Гульнара Закиевна
Published: July 2024

В статье разработан методический инструментарий оценки вероятности банкротства строительной организации, который включает в себя оценку системы показателей риска банкротства строительной организации и расчет интегрального уровня риска банкротства по logit-модели. Предложена методика оценки значимости факторов внешней среды, влияющих на финансовое состояние строительной организации. Предложена матрица определения необходимости разработки стратегии антикризисного управления строительной организацией, основанная на совмещении интегрального уровня риска банкротства и оценки силы влияния факторов внешней среды.

The article developed a methodological tool for estimating the probability of bankruptcy of a construction organization, which includes an assessment of the system of indicators of the bankruptcy risk of a construction organization, and the calculation of the integral level of bankruptcy risk using a logit model. A method for assessing the significance of environmental factors affecting the financial condition of a construction company is proposed. A matrix is proposed for determining the need to develop a crisis management strategy for a construction organization based on combining the integral level of bankruptcy risk and assessing the impact of environmental factors.
Development of Women’s Business in Modern Russia
Authors: Райманова Зухра Ильгизовна
Published: July 2024

В статье анализируется трактовка понятия «женское предпринимательство», рассматриваются особенности и роль женского предпринимательства в современном российском обществе. Обозначаются основные барьеры, препятствующие стремительному развитию женского предпринимательства. Предлагаются пути преодоления выявленных преград, для того чтобы женщина смогла реализовывать свои идеи и приносить пользу обществу.

The article analyzes the interpretation of the concept of «female entrepreneurship», discusses the features and the role of female entrepreneurship in modern Russian society. The main barriers to the rapid development of female entrepreneurship are indicated. Ways of overcoming the identified obstacles are proposed in order for a woman to be able to implement her ideas and bring benefits to society.
Electronic Commerce: Marketing Strategy for Small Businesses
Authors: Гайсина Радмила Руслановна , Хисаева Алия Инисовна
Published: July 2024

В данной статье рассмотрены вопросы, связанные с развитием электронной торговли на российском рынке, выявлены главные преимущества цифровой сферы торговли и ее значение для современного предпринимательства. Проанализированы основные интернет-стратегии, используемые малыми предприятиями для повышения эффективности управления сбытом готовой продукции. Разработаны рекомендации по выбору оптимальных моделей управления сбытом в электронном пространстве.

This article discusses issues related to the development of electronic commerce in the Russian market, identifies the main advantages of the digital trade and its importance for modern entrepreneurship. The main Internet strategies used by small enterprises to improve the efficiency of sales management of finished products are analyzed. Recommendations on the selection of optimal models of sales management in electronic space were developed.