bluuebunny/crossref_metadata_2025 huggingface dataset:
PTPN2 regulates metabolic flux to affect beta cell susceptibility to inflammatory stress
Authors: Kyung Kim Yong , Rachel Kim Youngjung , L, Wells Kristen , Sarbaugh Dylan , Guney Michelle , Tsai Chia-Feng , Zee Tiffany , Karsenty Gerard , S. Nakayasu Ernesto , Sussel Lori
Published: November 2023

Abstract

Protein tyrosine phosphatase N2 (Ptpn2) is a type 1 diabetes (T1D) candidate gene identified from human genome-wide association studies. PTPN2 is highly expressed in human and murine islets and becomes elevated upon inflammation and models of T1D, suggesting that PTPN2 may be important for beta cell survival in the context of T1D. To test whether PTPN2 contributed to beta cell dysfunction in an inflammatory environment, we generated a beta cell-specific deletion of Ptpn2 in mice (Ptpn2 βKO). While unstressed animals exhibit normal metabolic profiles, low and high dose streptozotocin (STZ) treated Ptpn2 βKO mice displayed hyperglycemia and accelerated death, respectively. Furthermore, cytokine treated Ptpn2 KO islets resulted in impaired glucose-stimulated insulin secretion, mitochondrial defects and reduced glucose-induced metabolic flux, suggesting beta cells lacking Ptpn2 are more susceptible to inflammatory stress associated with T1D due to maladaptive metabolic fitness. Consistent with the phenotype, proteomic analysis identified an important metabolic enzyme ATP-citrate lyase (ACLY) as a novel PTPN2 substrate.

Article Highlights

· Although the T1D susceptibility factor PTPN2 has been shown to function in beta cells in vitro, an unbiased assessment of its in vivo function in the context of T1D was lacking.

· Beta cells deleted for Ptpn2 have reduced mitochondrial function with age and are more susceptible to inflammatory stress associated with T1D due to maladaptive metabolic fitness. Consistent with the phenotype, the metabolic enzyme ATP-citrate lyase (ACLY) was identified as a novel PTPN2 substrate.

In the absence of PTPN2 beta cells are not able to metabolically compensate to an inflammatory environment.
High doses of exogenous glucagon stimulate insulin secretion and reduce insulin clearance in healthy humans
Authors: M. Gray Sarah , Goonatilleke Elisha , A. Emrick Michelle , O. Becker Jessica , N. Hoofnagle Andrew , Stefanovski Darko , He Wentao , Zhang Guofang , Tong Jenny , Campbell Jonathan , A. D’Alessio David
Published: November 2023

Abstract (186 words)

Glucagon is generally defined as a counter-regulatory hormone with a primary role to raise blood glucose concentrations by increasing endogenous glucose production (EGP) in response to hypoglycemia. However, glucagon has long been known to stimulate insulin release, and recent preclinical findings support a paracrine action of glucagon directly on islet b-cells that augments secretion. In mice, the insulinotropic effect of glucagon is glucose dependent and not present during basal euglycemia. To test the hypothesis that the relative effects of glucagon on hepatic and islet function were also varied with blood glucose, a group of healthy subjects received glucagon (100 ng/kg) during fasting glycemia or experimental hyperglycemia (~150 mg/dl) on two separate days. During fasting euglycemia, administration of glucagon caused blood glucose to rise due to increased EGP, with a delayed increase of insulin secretion. When given during experimental hyperglycemia, glucagon caused a rapid, 3-fold increase in insulin secretion, as well as a more gradual increase in EGP. Under both conditions, insulin clearance was decreased in response to glucagon infusion. The insulinotropic action of glucagon, which is proportional to elevated levels of blood glucose, suggests distinct physiologic roles in the fasting and prandial states.

Article Highlights

· This study was directed at the question of whether glucagon has divergent actions on insulin secretion at fasting compared to elevated blood glucose concentrations.

· Glucagon rapidly increased insulin secretion and reduced insulin clearance when given during experimental hyperglycemia at concentrations of blood glucose approximating the post-prandial state.

· When given during fasting euglycemia, glucagon increased endogenous glucose production and raised blood glucose, with a delayed rise of insulin secretion.

These data are compatible with distinct roles for glucagon on blood glucose regulation- as an incretin analogue after meals, and as a counter-regulatory hormone at eu- and hypo-glycemia.
Necrotic Ulcers from Occlusive Vasculopathy Associated with Monoclonal B Cell Lymphocytosis
Authors: Lim Delwyn Zhi Jie , Tee Shang-Ian , Cao Ling , Wang Ding Yuan
Published: November 2023

Abstract is missing (Shot communication)
Exploring the Role of Political Parties in the Enhancement of Women Representation in Parliament, Zambia: A phenomenological perspective
Authors: DAKA HARRISON
Published: November 2023

This study aimed at exploring the role of political parties in the enhancement of women representation in Parliament of Zambia. The continued underrepresentation of women in the Zambian National Assembly prompted undertaking this study. The Patriotic Front (PF) and the United Party for National Development (UPND) and the 2016 general elections were the main focus of the study.

This study was qualitative and a case study research design based on two major political parties, studied in depth using twenty six party officials, at different levels of party hierarchies who were purposefully selected.  Data was collected through in-depth interviews, narratives and unstructured questionnaires from the two political parties and the Electoral Commission of Zambia (ECZ) documents.

The study used an interpretive phenomenological theoretical framework based on discussions and reflections of direct sense perception and experiences of the role of political parties in enhancing women representation in the national assembly of Zambia. The starting point for using an interpretive phenomenology for this study was our ability to approach this study oblivious of a priori assumptions. Phenomenological theoretical framing was used as a broad and loose name for various types of analysis, which lay emphasis on experiences, interpretations, semiotics, narrative and discourse based on the phenomenological orientation of the Philosophy of social sciences.

Data was analysed and presented by the thematic approach as well as through frequency tables. The study found that both political parties had put in place strategies and mechanisms to enhance the representation of women in parliament and these included; having at least 30 percent women in decision-making positions, the adoption of the women’s wing concept, training and sensitisation, adoption of women in political party strongholds and relaxing of adoption requirements for women. Following the 2016 General elections, the PF made a pronouncement that the party would adopt 40 per cent women as parliamentary candidates. Nevertheless, the study found that the two political parties failed to meet their own regional and international targets on the number of women adopted to contest parliamentary seats. Thus, the study concluded that the lack of affirmative action, Nolle prosequi, Corruption and ignoring women voices taking place in political parties perpetuates women under representation in parliament in Zambia. This shows that political parties have a role to play to strengthen women representation in parliament through affirmative action in all party structures. The study urges political parties to seriously consider employing practical deliberate strategies and mechanism to increase the number of women in parliament since Zambia does not have a legislated quota.

Keywords: Phenomenology, Affirmative action, gender mainstreaming, Corruption, Nolle prosequi.
NOVO ENSINO MÉDIO: refletindo sobre o currículo das escolas do Ceará
Authors: Konzen Adriana Schneider Muller , Oliveira Priscila Rusalina Medeiros de , Santos Jean Mac Cole Tavares
Published: November 2023

Ao longo das últimas décadas as políticas educacionais do ensino médio vêm passando por diversos debates e reflexões. Dentro dessa perspectiva, se destaca a política curricular do Novo Ensino Médio. O presente trabalho de abordagem qualitativa, em uma perspectiva descentrada, tem como objetivo refletir sobre a construção do currículo das escolas de ensino médio em tempo integral no estado do Ceará, a partir do Novo Ensino Médio. Para tanto foi realizado estudo documental e de campo, com aplicação de instrumento de pesquisa com professores que atuam em uma escola de ensino médio em tempo integral, de Fortaleza, CE. Os resultados da pesquisa apontam para os diversos desafios que as escolas enfrentam na perspectiva da política do Novo Ensino Médio. Desafios que vão desde a constituição do currículo até a formação de professores.
PENGARUH JENJANG PENDIDIKAN DAN PENGALAMAN KERJA TERHADAP EFEKTIVITAS PEMBINAAN MASYARAKAT DARI PENYALAHGUNAAN NARKOBA OLEH KEPOLISIAN RESORT (POLRES) LAMPUNG TIMUR
Authors: Saputra Yayan , Suharto Suharto , Suhada Bambang
Published: November 2023

Keberhasilan seseorang dalam melakukan pekerjaan pada suatu instansi merupakan kesuksesan kerja, yang menjadi tolak ukur keberhasilan kerja Satuan Pembinaan Masyarakat dan Satuan Resnarkoba Polres Lampung Timur dalam menghadapi sistem pelaksanaan dan penyelenggaraan program kerja dapat dinilai dari kinerja anggota Satuan Pembinaan Masyarakat dan Satuan Resnarkoba Polres Lampung Timur. Oleh karena itu dalam hal memahami permasalahan yang ada di kalangan angota POLRI, terutama pada anggota Satuan Pembinaan Masyarakat dan Satuan Resnarkoba Polres Lampung Timur merupakan upaya yang tepat untuk meningkatkan kinerja pada instansi tersebut. Salah satu faktor yang menjadi masalah dan sangat menonjol di kalangan para anggota Satuan Pembinaan Masyarakat dan Satuan Resnarkoba Polres Lampung Timur adalah para anggotai kurang memahami bidang tugas dan fungsi pokok yang diembannya, sehingga dengan adanya hal tersebut jelas akan mempengaruhi kinerja baik secara perorangan maupun secara kolektif. Populasi sebanyak 32 orang termasuk peneliti dengan sampel yang digunakan sebanyak 32 responden. Pengambilan data ini dengan mengunakan quisioner sebagai alat bantu penelitian. Hasil analisis yang diperoleh dalam penelitian ini sebagai berikut: 1) Ada pengaruh signifikan antara jenjang pendidikan terhadap efektivitas pembinaan masyarakat dari penyalahgunaan narkoba oleh Kepolisian Resort (Polres) Lampung Timur. 2) Ada pengaruh signifikan antara pengalaman kerja terhadap efektivitas pembinaan masyarakat dari penyalahgunaan narkoba oleh Kepolisian Resort (Polres) Lampung Timur. 3) Berdasarkan hasil uji F dengan perhitungan SPSS dimana nilai F menunjukan terdapat pengaruh secara bersama-sama antara jenjang pendidikan dan pengalaman kerja terhadap efektivitas pembinaan masyarakat dari penyalahgunaan narkoba oleh Kepolisian Resort (Polres) Lampung Timur. Koefisien nilai R menunjukan besar derajat keeratan pengaruh jenjang pendidikan dan pengalaman kerja terhadap efektivitas pembinaan masyarakat dari penyalahgunaan narkoba oleh Kepolisian Resort (Polres) Lampung Timur tergolong kategori sedang. Dengan simpulan bahwa hasil penelitian terdapat pengaruh jenjang pendidikan dan pengalaman kerja terhadap efektivitas pembinaan masyarakat dari penyalahgunaan narkoba oleh Kepolisian Resort (Polres) Lampung Timur.
PENGARUH PENGELOLAAN ARSIP DAN KOMPETENSI PEGAWAI TERHADAP KUALITAS LAYANAN DI DINAS PERPUSTAKAAN DAN KEARSIPAN KABUPATEN LAMPUNG TIMUR PROVINSI LAMPUNG
Authors: Rahayu Uut Marsetyawati , Suharto Suharto , Mazni Afdal
Published: November 2023

Tujuan penelitian ini untuk mengetahui pengaruh secara parsial maupun secara simultan pengelolaan arsip dan kompetensi pegawai terhadap kualitas layanan di Dinas Perpustakaan dan Kearsiapan Kabupaten Lampung Timur Provinsi Lampung. Penelitian ini merupakan penelitian kuantitatif yang menguji kausalitas (pengaruh) variabel bebas yaitu X1 (pengelolaan arsip) dan X2 (kompetensi pegawai) terhadap variabel terikat yaitu kualitas layanan (Y). Metode pengumpulan data menggunakan kuesioner, dengan populasi sebanyak 720 responden dan sampel penelitian diambil dengan rumus slovin sebanyak 89 responden, yaitu pengunjung Kantor Perpustakaan dan arsip Daerah Kabupaten Lampung Timur. Berdasarkan hasil penelitian maka diketahui baik secara partial variabel pengelolaan arsip berpengaruh sebesar 11,5% dan variabel kompetensi pegawai berpengaruh sebesar 29,9%. Selanjutnya variabel pengelolaan arsip dan kompetensi pegawai secara Bersama-sama memiliki pengaruh sebesar 30,3% terhadap kualitas layanan di Dinas Perpustakaan dan Kearsiapan Kabupaten Lampung Timur Provinsi Lampung. Kemudian diantara kedua variabel tersebut yang paling memberikan pengaruh pada kualitas layanan adalah kompetensi pegawai.
A new operator of primal topological spaces
Authors:   Al al-Bayt University, Faculty of Sciences, Department of Mathematics, P.O. Box 130095, Mafraq 25113, Jordan, Al-Omari Ahmad , Acharjee Santanu ,   Department of Mathematics, Guwahati-781014, Assam, India, Özkoc Murad ,   Mugla Sitki Kocman University, Faculty of Science, Department of Mathematics  48000, Mentese-Mugla, Turkey
Published: November 2023

Recently, Acharjee, Özkoc and Issaka introduced a new structure in topology named primal. Primal is the dual structure of grill. The main purpose of this paper is to introduce an operator using primal and obtain some of its fundamental properties. Also, we define the notion of topology suitable for a primal. We not only obtain some characterizations of this new notion, but also investigate many properties.
Penentuan Alternatif Strategi Pemasaran Peternakan Ayam Broiler PT Unggas Taat Bersinar Kalipucang Pangandaran
Authors: Perdana Yogastian , Agustin Megaria , Permana Iqbal Zaky , Wiliantika Wiliantika , Fitriani Anita , Mutaqin Bambang Kholiq
Published: November 2023

Pengamatan ini bertujuan untuk mengetahui saluran pemasaran, menganalisis faktor-faktorkekuatan, kelemahan, peluangan dan ancaman dalam peternakan ayam broiler serta merumuskan alternatif strategi pengembangan peternakan ayam broiler di Desa Emplak Kecamatan KalipucangKabupaten Pangandaran. Pengamatan dilakukan di peternakan ayam broiler di Desa Emplak dengancara pengamatan dan wawancara langsung. Analisis data yang digunakan yaitu analisis matrik SWOT dan dilanjutkan dengan analisis QSPM. Berdasarkan hasil pengamatan diketahui bahwasaluran distribusi pemasaran ayam broiler di Desa Emplak hanya terdapat satu pola pemasaranyaitu PT UTB → Broker → Pasar Becek → Konsumen. Hasil analisis matrik SWOT yang diperoleh yaitu strategi (WO) yaitu membuka rekrutmen pegawai untuk mempermudah manajemenpemeliharaan dan meningkatkan kualitas SDM dengan mengadakan pelatihan pada pegawai,selain itu terdapat pula strategi (WT) yaitu diperlukan upaya untuk memaksimalkan produksi ayambroiler yang sudah ada dan meminimalisir mortalitas pada saat musim-musim tertentu. Pada hasil analisis QSPM diperoleh alternative strategi 3 yaitu peningkatan faktor kunci internal meliputi mempertahankan kemitraan dan memaksimalkan faktor produksi, sedangkan faktor kunci eksternal meliputi pembukaan lapangan kerja untuk memaksimalkan produksi dalam memenuhi kebutuhan pasar yang semakin meningkat.
The outer ring of a circular structure in the Marche Region, Central Italy: Evidence of a non-extraterrestrial origin
Authors: Colucci Sabrina , Fidani Cristiano
Published: November 2023

Google Earth images in the Marche Region of Central Italy revealed a circular structure consisting of a ring system made up of concentric hills and valleys. Cartography, DEM, geological, and available geophysical data were used to constrain the possible origin of the structure. Located in the Messinian foredeep deposits of the Central Apennines, it has a rim diameter of 3.75 km and a central uplift connected to its southernmost part. As it was formed in the clays of the Lower Pliocene, and clays are believed to have emerged definitively after the Upper Pliocene, its age might be constrained to the Lower Pleistocene. Similar concentric structures are usually found in impact craters, sedimentary domes, and volcanic landforms. As salt domes and magmatic activity are not found in this region, this study seeks to validate the results of previous work that it was the result of an ancient impact crater of hydrological, brachyanticline, or clayey diapiric origins. Specifically, an observed second ring portion with a curvature radius about double the first in size will be investigated in this work. This second ring portion appears to be concentric to the first one and is visible along its northern and western parts. Although double concentric rings are usually due to impact craters, the absence of the ring portion in the other two directions and the probable deviation of a river, deduced by studying hydrography, support the hypothesis that it might be of clay diapir origin.
A comparative study of the relationship between audit quality and earnings management in the markets of Iraq and Oman
Authors: Wahab Yaqdhan Abd Ali Kareem , Velashani Mohammad Ali Bagherpour , Salehi Mahdi
Published: November 2023

The present study investigates the relationship between audit quality and earnings management in banks listed on the Stock Exchange of Iraq and Oman. This paper used audit firm size, auditors’ industry expertise, audit report timeliness, auditor change, and auditors’ opinions to measure audit quality. Financial statements, notes attached to financial statements, and reports of independent auditors of 28 banks listed on the Iraqi Stock Exchange and 8 banks listed on the Oman Stock Exchange during the financial period of 7 years (2015 to 2021), and hypotheses were tested using EViews software and panel data. The results of the hypothesis testing showed no significant relationship between the firm size and the auditors’ change and earnings management for both countries (Iraq and Oman). This is while the relationship between the auditor’s industry expertise, the timely presentation of the audit report, and the auditor’s opinion and earnings management for both countries (Iraq and Oman) is negative.
Automation of Aircraft Fatigue Life Estimation
Authors: Gajek Stanisław
Published: November 2023

The fatigue is an important factor in aircraft operation. A correct estimation of structure fatigue life is crucial for user and payload safety. However, due to high amount of data gathered during a typical recording of load spectra for different types of flights, the overall results become prone to human error. The paper describes development of a software able to perform an automated, in-depth analysis of data recorded with onboard accelerometers. Using the Rainflow Cycle Counting method, it transforms received data points into a Markov matrix. The prepared array is then recalculated into a half-cycle matrix, which can be collapsed into scalar value of fatigue level using the Palmgren-Miner rule. The method was tested with loads recorded during a typical flight conducted according to the Polish NSTS-06 flight scenario and simulated camera mounting fixed to a multirotor.
Efficiency and Fatigue/Endurance Laboratory Tests of Aviation Friction Brakes
Authors: Skorupka Zbigniew
Published: November 2023

Brakes are one of the most important safety systems in moving vehicles and machines. In vehicles such as cars or motorcycles brakes are used for stopping, controlling speed, and sometimes changing direction of travel. In aircraft, the main function of brakes is to reduce landing speed. As landing is one of the most dangerous maneuvers in aircraft operation, brakes must be efficient and reliable in order to ensure safety of the crew, passengers, and cargo. The most efficient brakes nowadays are friction brakes where velocity is controlled by friction of a pair of specially designed materials, which ensure stable and high friction coefficient over the course of the required braking process. The process itself is the dissipation of energy during aircraft movement which generates very high temperatures in friction materials during the time of the braking process. The materials and the whole brakes have to be temperature resistant, and we must ensure braking parameters are stable during the whole process. The same principle relates to the endurance/fatigue of the brake assemblies which must be durable enough to survive as high number of braking cycles as possible without any failure, which can result in fatal consequences. Every friction pair and every newly designed brake assembly must be laboratory tested for efficiency and endurance/fatigue in order to be used in an aircraft or vehicle. In this paper, we present the basic set of laboratory tests in the scope of friction materials and brake assemblies. Results of the tests are used as confirmations/proofs of proper and safe operation of the brakes for use in vehicles, especially in aircraft but also in land-based vehicles.
Investigating public governance models in Slovenia and Japan: a comparative survey on state and local government
Authors: ARISTOVNIK Aleksander
Published: November 2023

Public administration and governance must adapt to the changing socio-economic environment, improving quality, process efficiency, and collaboration. Hence, public administration and public governance models have been significantly modified multiple times, resulting in differences in public governance practices. This paper examines different public governance models’ principles in Slovene and Japanese public administration. It quantifies elements based on the models' principles and applies them to an empirical case using a survey of 55 Slovene and 135 Japanese public managers. The independent samples t-test examines the differences in characteristics of public governance practices between state administration and local government in Slovenia and Japan. The results show that state administration institutions in both countries are strongly characterised by the (Neo)Weberian model’s principles, while Slovenia's local government leans towards Digital-era governance (DEG) and good governance (GG) principles. Japan's state and local administrations show equal presence of New public management (NPM), DEG, and GG models. The study aims to bridge a research gap by providing new findings on how different public governance models can be found at various Slovene and Japanese public administration levels and offers insights for public managers and policymakers for future public administration reforms.
Main factors and causes that are influencing the digital competences of human resources
Authors: ANDRONICEANU Armenia , SABIE Oana-Matilda , GEORGESCU Irina , DRUGĂU-CONSTANTIN Andreea-Ligia
Published: November 2023

The integration of digital technologies in public administration is influenced by the digital competences of human resources. The objectives of this research are to identify the main factors and causes that influence human resources’ level of digital competences and to find out the correlations between factors, causes, and digital competences. The survey was conducted within the National Agency of Civil Servants (NACS) responsible for the management of civil servants from the Romanian public administration. 25 variables were selected and grouped in three categories. The main research instruments used were: SPSS and Principal Component Analysis. According to the research results, the main factors influencing digital competences are social factors, extrinsic motivation factors, and administrative and managerial factors. The main causes with a relevant impact on digital competence development are data security and privacy risks, the dynamic of technologies, lack of continuity in ICT integration in organization activities, and excessive bureaucracy. All variables in the model have positive correlations. The results of the research are useful and interesting both for scholars and governmental institutions. The causes, factors, and correlations between them are discussed for the first time in the specialized literature and are raising up the key elements of digital competences that should be taken into account for an efficient digital transformation of public administration.
Analysis of the revitalization process of voivodeships in Poland based on UTASTAR and TOPSIS methods
Authors: ŁUKOMSKA-SZAREK Justyna , WÓJCIK-MAZUR Agnieszka , MARTYNKO Anna
Published: November 2023

Modern-day local governments face various challenges in the realms of geopolitics and socio-economic factors. Many times, intense transformations lead to crisis situations. Revitalization is a tool used by local governments to repair locally degraded areas. The paper focuses on discussing selected aspects of the revitalization process, using TOPSIS and UTASTAR methods. The study covered local government voivodeships in Poland and was based on secondary data for 2020-2021 published on the Statistics Poland website. The methods used made it possible to construct rankings that indicated that the voivodeships that could be considered leaders in revitalization are Greater Poland Voivodeship (UTASTAR) and Lubusz and Silesian Voivodeship (TOPSIS), whereas their opposite was the Opole Voivodeship.
Government assistance programs for internally displaced persons: assessing the impact on economic growth and labour market
Authors: YURCHYK Halyna , MISHCHUK Halyna , BILAN Yuriy
Published: November 2023

In this paper, we analyse the economic influence of expenditures on social protection of internally displaced persons (IDPs) trying to find a response to the research question: if social expenditures can be used in public administration as an effective tool for fostering economic growth and labour market development, or their only purpose is social support within the social responsibility of the government. Thus, we conduct our research using the case of Ukraine with its unprecedented scope of internal displacement caused by the war. To analyse the dependencies between social expenditures and economic growth we use the multiplier calculations. As a result, we found out that the expenditures on social protection of IDPs cause the growth of GDP with a ratio of at least 1:1,23. Besides, due to the indirect economic influence of social expenditures on consumer spending, it was possible to support no less than 13,7 thousand workplaces annually. To substantiate this impact, we used the authors’ method based on the evaluation of marginal propensity to consume and average cost to support workplaces (found as a dependency between consumer spending and employment). The proposed methodology can be useful for scientific analysis and justification of policy measures aimed at different social groups needing financial assistance from the government.
Institutional Constraints of Church Lobbying In the USA
Authors: Parenkov D. A.
Published: November 2023

The article presents an analysis of the restrictions on legislative lobbying and the ban on participation in political campaigns for religious organizations covered by section 501 (c) (3) of the Internal Revenue Code (IRC). The existing institutional framework for lobbying activities of such organizations is considered in the context of the recommendations of the Internal Revenue Service (IRS) for churches and religious organizations and the United States Conference of Catholic Bishops guidelines for catholic organizations on acceptable forms of political and lobbying activity.
Public Policy Agenda in a Turbulent World
Authors: Yakunin V. I.
Published: November 2023

The world is experiencing dramatic transformations determined by political and economic shifts in the roles of the West and the East, the North and the South. These changes pose huge challenges on the global and national levels, testing international institutions and national governments and creating crises on all levels and in different spheres. The article examines how the public policy agenda is changing under permanent shocks. The author comes to the conclusion that the public policy agenda is under the pressure of short-term and emergency-oriented tasks in expense of strategic issues, but in order to provide sustainable development, the governments should support long-term projects, internal social coherence and external mutual dialogue, using the most advanced tools of social and natural sciences, as well as the opportunities of digitalization. Only this proactive, but careful and civilizationally grounded approach will provide peaceful solution of current and future challenges.
PENGARUH MOTIVASI KERJA, KEPUASAN KERJA, DAN LINGKUNGAN KERJA TERHADAP LOYALITAS KARYAWAN
Authors: Widnyasari Ni Wayan Diah , Surya Ida Bagus Ketut
Published: November 2023

Every organization needs to have the right strategy in order to survive in carrying out its operational activities. Employee loyalty has attracted a lot of attention because it is the expectation that motivated and loyal employees will act in the best interests of the organization. This study aims to determine the effect of work motivation, job satisfaction, and work environment on employee loyalty at PT. Mabhakti Denpasar. The number of samples is 40 employees. The data analysis technique used is descriptive statistics and inferential statistics, multiple linear regression analysis. Based on the results of the analysis it was found that work motivation, job satisfaction and work environment have a positive and significant effect on employee loyalty. The results of this study imply that high work motivation can increase loyalty, the more satisfied employees are with their work, the higher employee loyalty, and a good work environment can increase employee loyalty.

Keywords: Work Motivation; Job Satisfaction; Work Environment; Employee Loyalty
PENGARUH KEPEMIMPINAN DAN MOTIVASI KERJA TERHADAP DISIPLIN KERJA DAN KINERJA PEGAWAI PADA YAYASAN KEBAKTIAN PROKLAMASI
Authors: Dewi Desak Made Pradnya , Surya Ida Bagus Ketut
Published: November 2023

The purpose of this study was to analyze the influence of leadership and work motivation on work discipline and employee performance. This research was conducted at the Yayasan Kebaktian Proklamasi, and the number of samples used was 82. The method of determining the sample in this study is the saturated sampling method. The research instrument used in this study was a questionnaire distributed to employees of the Yayasan Kebaktian Proklamasi. The collected data was then analyzed using path analysis and the Sobel test with the help of the SPSS program. The results of the study show that leadership has a positive and significant effect on employee discipline at the Yayasan Kebaktian Proklamasi. Motivation has a positive and significant effect on employee work discipline at the Yayasan Kebaktian Proklamasi. Leadership has a positive and significant effect on employee performance at the Yayasan Kebaktian Proklamasi. Motivation has a positive and significant effect on employee performance at the Yayasan Kebaktian Proklamasi. Work discipline has a positive and significant effect on employee performance at the Yayasan Kebaktian Proklamasi. Work discipline is a variable mediating the influence of motivation on employee performance at the Yayasan Kebaktian Proklamasi. The implication of this research is that the Yayasan Kebaktian Proklamasi must continue to improve leadership and motivation within the company so that employees can improve their work discipline, which will improve employee performance at the Yayasan Kebaktian Proklamasi.

Keywords: Leadership; Work Motivation; Work Discipline; Employee Performance
Efektivitas dan Efisiensi Penggunaan Faktor Produksi Usahatani Kangkung Pada Kelompok Tani Setia Tani di Desa Ciaruteun Ilir, Kecamatan Cibungbulang, Kabupaten Bogor
Authors: JENICA IRENA DEA , WIDHIANTHINI WIDHIANTHINI , SUAMBA I KETUT
Published: November 2023

The Effectiveness and Efficiency of the Use of Production Factors for Water Spinach Farming in Setia Tani Farmer's Group in Ciaruteun Ilir Village, Cibungbulang District, Bogor Regency

The agricultural production process is driven by the fulfillment of production factors needs. Lacking of production factors can affect farm production. This condition requires farmers to use production factors effectively and efficiently. This study aims to analyze the effect, effectiveness and efficiency of production factors. Data were obtained through interviews with questionnaires to 52 farmers. The research analysis used Cobb-Douglas analysis which was processed using SPSS software. The results showed that the use of water spinach production factors together had an effect on water spinach production. In the other hand, manure and urea were not partially significant. Meanwhile, land area, labor, and seeds have a significant effect. The use of production factors has not yet reached the effective and efficient level. This can be seen from effectiveness level by comparing the MPP and APP values which are only around 6.3-42.6%. The analysis result of the efficiency of labor variable and the use of manure are inefficient so that their use must be reduced. Meanwhile the area of land, seeds, and urea fertilizer is not yet efficient, meaning that the use of production factors must be increased in terms of the NPM/Px value.
Pendapatan dan Studi Kelayakan Pertanian Kopi Arabika Kintamani di Kabupaten Bangli Bali
Authors: YUDHARI I DEWA AYU SRI , ANGGRENI I GUSTI AYU AGUNG LIES
Published: November 2023

Income and Feasibility Study of Kintamani Arabica Coffee Farming in Bangli Regency, Bali

Plant characteristics in the plantation subsector are classified as perennial and annual crops. Coffee as a plantation commodity has an essential role in the Indonesian economy. Kintamani coffee is grown in a specific area at an elevation of more than 900 meters above sea level. The Kintamani Bali coffee agroecosystem is ideal for Arabica coffee plants and homogeneous farming systems. This study aims to determine how much income Arabica coffee farming generates and assess the feasibility of the business. The research was conducted in Catur Village, Kintamani District, Bangli Regency. The research location was determined by purposive sampling based on the consideration that Catur Village is the largest coffee center and has the largest Arabica coffee plant population in the Kintamani District, Bangli Regency. The respondents of this study were Arabica coffee farmers in Catur Village. The sample was selected by simple random or random sampling, with a sample size of 30 farmers. The results showed that the average income of Kintamani Arabica coffee farming in Bangli Regency was 17,508,497 IDR/year/ha or 1,459,041 IDR/month/ha. The feasibility analysis of Kintamani Arabica coffee farming shows that the R/C ratio was 4.40, the B/C ratio was 3.40, the production BEP was 96.81 kg/ha, and the price BEP was 980.001.20 IDR/year/ha. According to theese findings, Kintamani Arabica coffee farming in Bangli Regency is feasible because it has benefited farmers.
Biased Behavior and Stock Investment Decisions of Investors in Bali, Indonesia
Authors: Salasa Gama Agus Wahyudi , Yeni Astiti Ni Putu , Eka Mitariani Ni Wayan
Published: November 2023

Investment decisions are often affected by irrational behavioral factors that cause improper logical analysis. Herding and overconfidence are two behaviors that lead to biased decision-making, specifically regarding investment. Therefore, this study aimed to test the effect of herding and overconfidence on investment decisions moderated by financial knowledge and attitude. Using a sample of 267 stock investors, the test was conducted with PLS-SEM. The results showed that overconfidence positively influences individuals' investment decisions, while herding has no effect. Financial knowledge and attitude were found not to moderate this effect but could act as predictor variables with a significant positive impact on investment decisions.

Keywords: Herding; Financial Knowledge; Financial Attitude; Financial Behavior Overconfidence.
VULNUS INCISIVUM IN TERRIER DOGS
Authors: Sawitajaya I Made , Pemayun I Gusti Agung Gde Putra , Wirata I Wayan
Published: November 2023

Vulnus incisivum is the occurrence of tissue continuity disruption resulting in tissue separation that occurs due to the sharp object incision so as to break the tissue. The objective of this research is to determine the correct procedure of vulnus incivisum surgery and post surgery treatment A terrier dog named Browni who is 1 year old, weighs 7kg. Physically dogs have been observed to experience skin disorders with appetite for eating and drinking, deficiencies and normal urination. Based on the history and clinical examination Browni dog was diagnosed with vulnus incisivum on the left thigh with a prognosis of fausta. Vulnus incisivum is treated surgically by cleansing the wound (physiological NaCl), then removing dead or damaged tissue (debridement) to make the wound merge, the next step being wound closure (suturing). After the operation, antibiotics were given cefotaxim (IV) followed by cefixime (PO) and anti-inflammatory in the form of dexamethasone (PO) until the fifth day. On the fifth postoperative day, the wound began to improve. To accelerate the healing process, the ornwe or the animal are expected to provide postoperative care.
Sepse fúngica multirresistente em UTI neonatal – Relato de caso
Authors: Nogueira da Silva Melo Daniella , Rodrigues do Carmo Barreto Tassia , Machado de Souza Pedro , Almeida de Souza Maria Cristina
Published: November 2023

Introdução: A sepse neonatal (SN) é uma síndrome clínica caracterizada por manifestações clínicas sistêmicas, em especial por alterações hemodinâmicas, resultantes da presença de microrganismos patogênicos em fluido normalmente estéril, no primeiro mês de vida do neonato. A SN é uma importante causa de sequelas neurocognitivas e mortalidade neonatal. Clinicamente, se caracteriza por sinais e sintomas relacionados à infecção no primeiro mês de vida, com ou sem bacteremia. O principal agente causador da SN é o fungo do gênero Candida sp. Relato de caso: Recém-nascido (RN) com idade gestacional de 36 semanas e 4 dias necessitou de reanimação neonatal. Com 24 horas de vida, apresentou choque séptico, convulsão, apneia e hipertensão pulmonar, havendo necessidade de antibioticoterapia. O resultado da cultura do aspirado traqueal evidenciou o fungo Candida parapsilosis, sensível ao fármaco micafungina sódica. Discussão: As infecções fúngicas estão comumente associadas à morbimortalidade em recém-nascidos pré-termo com idade gestacional <32 semanas e peso de nascimento <1.500g. Cabe destacar que existem apresentações clínicas evidentes, como dificuldade respiratória, apneia, letargia, febre ou hipotermia, icterícia sem outra causa determinante, vômitos e diarreia, ou ainda manifestações cutâneas, incluindo petéquias, abscesso e escleredema, que foramobservados no RN já nas primeiras 24 horas de vida. Em relação ao tratamento da candidíase invasiva no RN cujo caso se relata, instituiu-se terapia medicamentosa com micafungina sódica. Conclusão: O diagnóstico de SN, nas primeiras horas de vida do RN foi fundamental para a instituição da terapêutica evitando o óbito.
Correlation between the Eosinophil Colonic Mucosa Density and Severity of Ulcerative Colitis
Authors: Aulia Nisma , Mulya Deshinta Putri , Bayupurnama Putut , Ratnasari Neneng
Published: November 2023

Background: The inflammatory process of ulcerative colitis (UC) involves eosinophils. Eosinophils are not only related to the severity of UC but also to clinical improvement. The role of eosinophils in colonic mucosa has not been fully understood. This study aims to determine the correlation between the density of eosinophils in the colonic mucosa and the severity of ulcerative colitis.Method: This is a prospective cross-sectional study with consecutive sampling between August 2020 and July 2021. The subjects were UC inpatients/outpatients at Dr. Sardjito Hospital who met the inclusion and exclusion criteria. The number and location of the biopsies are determined based on a colonoscopy performed by a Gastroenterology-Hepatology Consultant. An Anatomic Pathology Specialist examined the eosinophil colonic tissue. The severity of UC was classified using the Truelove Witts score. Data analysis using a computer program with a p-value 0.05 was considered statistically significant.Results: There are 3 UC severity categories according to the Truelove Witts score: 22 mild (45.8%), 9 moderate (18.8%), and 17 severe (35.4%). Seven participants (14.6%) had eosinophilia, with a median eosinophilia score of 203.33 cells/microL (0–1470 cells/microL). Five participants (10.4%) with colonic mucosal eosinophilia, with a median value of 14.13 cells/HPF (0–172 cells/HPF). The density of colonic mucosal eosinophils and the severity of UC had a moderate connection (r = 0.396; p = 0.005).Conclusion: There is a significant correlation between the density of eosinophils in the colonic mucosa and the severity of UC.
The Impact of a Handheld Ultrasound Device in a Rheumatic Heart Disease Screening Program in Ethiopia
Authors: Kaltenborn Zach , Zewde Anteneh , Kirsch Jonathan , Yates Michelle , Tessier Katelyn , Nemec Eileen , Johannsen Ronald
Published: November 2023

Background: Rheumatic heart disease affects 33 million people in low and middle income countries and is the leading cause of cardiovascular death among children and young adults. Penicillin prophylaxis prevents progression in asymptomatic disease. Efforts to expand echocardiographic screening are focusing on simplified protocols, non-physician ultrasonographers, and portable ultrasound devices, including handheld ultrasound. Recent advances support the use of single-view screening protocols. With the increasing availability and low cost of handheld devices, studies are needed to evaluate their performance in these settings.

Methods: We conducted a retrospective study comparing the rate of screen positive ultrasounds before and after the use of a handheld ultrasound in an RHD screening program in Ethiopia. We also performed a cross-sectional device comparison in 19 at-risk school-children participating in the rheumatic heart disease screening program.

Results: Between March of 2019 and Jan of 2022, 6631 children were screened for rheumatic heart disease of whom 4029 were screened after the introduction of a handheld device. Before the use of the handheld ultrasound device 291 (11.2%) children had a screen positive ultrasounds  compared with 167 (4.1%)  afterwards (p < 0.001). We also compared non-expert to expert interpretation by device and found a significant difference in interpretation for the Lumify (p=0.025). There was a trend towards shorter jet length by color Doppler in the handheld ultrasound device for both expert and non-expert review.  

Conclusions: Our study highlights that the screen-positive rate in a RHD screening program is influenced by the device being used in the screening process.
Renal Transplant Artery Stenosis and Kinking: An Unusual Association
Authors: Sosa Barrios R. Haridan , Burguera Vion Victor , Casillas Sagrado Ester , Villa Hurtado Daniel , Jiménez Álvaro Sara , Martín Capón Irene , Fernández Lucas Milagros , Rivera Gorrín Maite E.
Published: November 2023

Renal artery stenosis of the kidney allograft associated with kinking is not a frequent finding. As a correctable cause of graft dysfunction, it is important to diagnose it as soon as possible to avoid further graft damage and improve graft and patient survival. As pulsed wave Doppler ultrasound mapping of the graft’s renal arteries is essential to diagnose possible alterations, point of care ultrasound (POCUS) is a highly useful tool for early diagnosis. We present a case in which nephrologists performed this examination promptly allowing a timely diagnosis and treatment plan.
Cough Causing Abdominal Pain? A Rapid POCUS Diagnosis of Rectus Sheath Hematoma
Authors: Noel William , Brian B. Donahue
Published: November 2023

We present a case of a 59-year-old man who arrived to the emergency department with abdominal pain and bruising after coughing. Point of care ultrasound (POCUS) was used to make the diagnosis of rectus sheath hematoma (RSH). This diagnosis was made within minutes of arrival to the ED and subsequently confirmed on computed tomography (CT) of the abdomen. As abdominal ultrasound is a technically straightforward imaging technique which includes a sensitivity that rises about 90%, its utilization to identify rectus sheath hematoma can reduce the rate of CT imaging and time to diagnosis for this pathology.
Fransa ve Türkiye’de Tarımda Çalışanların Sosyal Güvenliği
Authors: Balcı Derya , Gün Arife Sema
Published: November 2023

Tarımsal üretim doğal koşullarda yapılan ve mevsimlerin koşullarına bağlı olan üretimdir. Bu nedenle tarım sektörü doğası gereği tehlikeli ve fiziksel risklerin fazla olduğu bir sektördür. Tarım sektöründe çalışanlar faaliyetleri sırasında tehlikeli ve fiziksel risklere maruz kaldıkları gibi sosyal korumanın dışında da tutulabilmektedir. Tarımda çalışanlar ve bakmakla yükümlü oldukları ailelerinin de diğer sektörlerde olduğu gibi sosyal korumadan yararlanması gerekmektedir. Dünyada sosyal güvenlik ilk olarak sanayi sektöründe ortaya çıkmış ve sonrasında hizmet ve tarım sektörlerinde de uygulanmaya başlanmıştır. Amerika Birleşik Devletleri sosyal güvenliği 1935 yılında yasayla destekleyen ilk ülke olmuş, yasanın ilk halinde tarım kesimini dışlamışsa da zamanla yasada yapılan yeni düzenlemelerle tarım kesimi sosyal güvenliğe dâhil edilmiştir. Bu çalışmada, Fransa ve Türkiye’deki yasalar ve literatürden elde edilen bulgular kullanılarak, tarım sektöründe sosyal güvenliğin nasıl sağlandığı incelenmiştir. Fransa’nın tarım alanı 27.476.930 hektar olup Avrupa Birliği’nin en büyük tarımsal alanına sahip ülkesidir. 2020 yılı verilerine göre Avrupa Birliği ülkeleri içinde en büyük tarım üreticisi ülke konumunda olan Fransa, tarımsal ürün ihracatında birlik içinde üçüncü sırada yer almaktadır. Ayrıca Fransa tarım sektörü için kapsamlı sosyal güvenlik düzenlemelerine sahip bir ülkedir. Tarım sektöründe sosyal güvenliği sağlamak için, tarımsal sosyal koruma sistemi kullanılmaktadır. Bu sistem, tarım, ekonomi, maliye ve kalkınma bakanlıklarının ortak gözetimi altında çalışmaktadır. Türkiye’de de yıllar içinde tarım sektörünü sosyal güvenliğe dâhil etmek için çeşitli düzenlemeler yapılmıştır. Ancak, tüm düzenleme dönemlerinde tarım sektörünü tamamen kapsayan zorunlu bir sosyal güvenlik sistemi oluşturulamamıştır.
Simulação realística como estratégia para o aprendizado dos futuros enfermeiros
Authors: Ribeiro Bárbara Janine Cardoso , Lima Cássia Regina , Pereira Taisy Franciele Teixeira , Santos Thiago Figueiredo dos , Paula Agnes Fernanda Souza Silva Oliveira de , Santos Bruna Marcely da Cruz , Clemente Danúbia Maria Martins , Rodrigues Fernanda Martins , Paixão Gislange Cassimiro da , Campos Luana Cheila
Published: November 2023

Objetivo: Relatar uma experiência acerca da importância da capacitação dos futuros profissionais da saúde sobre o correto manejo da Ressuscitação Cardiopulmonar (RCP) em sala de parto, por meio da simulação realística. Relato de experiência: Em uma instituição privada na cidade de Belo Horizonte, 22 acadêmicos de Enfermagem foram submetidos à simulação realística sobre uma situação de emergência a um paciente neonato na sala de parto. Os mesmos foram avaliados conforme diretrizes da Sociedade Brasileira de Pediatria (SBP) em relação à reanimação neonatal. Diante das simulações, foi constatado que os grupos que não seguiram as diretrizes do fluxograma de reanimação neonatal da SBP, ocasionaram no insucesso do manejo da RCP. Foi constatado também que fatores como estabilização emocional e clareza de comandos, possuem grande relevância para que os procedimentos sejam perfeitamente efetivados. Considerações finais: Os primeiros instantes após o nascimento, são um grande desafio de sobrevivência para um neonato e nesse cenário, é incontestável a importância de métodos inovadores para a capacitação dos futuros enfermeiros. Conhecimento, habilidade e atitude são fatores essenciais para a promoção da segurança do paciente, proporcionando aos futuros profissionais a autonomia para a correta execução dos procedimentos e reduzindo o índice de mortes evitáveis ao neonato em sala de parto.