bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH PAJAK TERHADAP HUTANG PADA SEKTOR PROPERTI DAN REAL ESTATE DI INDONESIA
Authors: Putri Yasmin Nugraha , Ayuni Galuh Refadias , Leon Farah Margaretha
Published: February 2025

This research was conducted to examine the effect of tax aggression and sales on financial leverage. The sample used in this study is property and real estate companies listed on the Indonesia Stock Exchange (IDX) for the 2014-2018 period. Sampling can be analyzed by purposive sampling to obtain 35 property and real estate companies that can be taken. The dependent variable is the financial leverage received using debt. Tax aggression and sales as an independent variable using taxes expense and sales. Whereas net income, market book ratio, and firm size are the control variables of net income, stock price, total shares, total equity, and firm size. Panel data regression methods, and individual tests (t-test) were used in this study. The results showed that sales, net income, market to book ratio and firm size had significant to financial leverage. While the tax aggression does not affect financial leverage. The implication of this research is for financial managers to be able to increase sales, net profits, internal fund and total company assets. Further researchers should use the other variables to measure the financial leverage such as free cash flow. The novelty in this research is to use effective tax rates to measure tax aggression where in previous research using scale by total assets to measure tax aggression.
 
Keywords: financial leverage; firm size; market to book ratio; net income; sales; tax aggresion
PENGARUH ORGAN TATA KELOLA PERUSAHAAN TERHADAP MANAJEMEN LABA RIIL
Authors: Florensia Stella , Trisnawati Estralita , Oktavia Oktavia
Published: February 2025

This study aims to determine the effect of the Corporate Governance organ by using the activities of the independent Corporate Governance organs (ie: financial expertise, gender, and political connections of the Corporate Governance organs) on real earnings management. Real earnings management is measured by abnormal measurements of each proxy using residuals, namely, Abnormal Cash Flow Operations, Abnormal Production Costs, and Abnormal Discretionary Expenses. The population in this study are publicly listed companies listed on the Stock Exchange, and the sample used was manufacturing companies listed on the Stock Exchange in the 2014-2018 period. Based on the purposive sampling method, 124 samples were obtained from manufacturing companies. The results showed that the activities of the Corporate Governance organs that have an influence on real earnings management are financial expertise. Furthermore, the activities of other Corporate Governance organs such as gender and political connections have no effect on real earnings management.
Keywords: corporate governance, financial expertise, gender, political connections, real earnings management
PENTINGNYA PENGETAHUAN PAJAK UNTUK MENINGKATKAN KEPATUHAN PAJAK UMKM (STUDI KASUS UD SUMBER AYU)
Authors: Nabila Huwaidah , Dwianika Agustine
Published: February 2025

Income tax revenue in the MSME sector has a potential to has a large increasing percentage due to the increasing number of MSMEs currently the government made an effort with issuing a special tax rate for MSMEs listed in Government Regulation No.46 of 2013 with income tax rate at 1% which is currently changed into Government Regulation No.23 of 2018 with a reduced rate to 0,5%. The purpose of this journal is to provide tax knowledge in general to MSMEs in an effort to improve tax compliance of MSME. The researcher conducted a case study on one of the MSMEs, namely Sumber Ayu. This paper uses two types of dara, that is primary data in the form of direct interview with respondent who meet the criterian and secondary data in the form of report on recording gross income (turnover) which is obtained directly from respondent who meet the criteria. The result of this paper is Sumber Ayu didn’t calculate, pay and report income tax due to its lack of tax knowledge.
 
Keywords: MSME, tax knowledge, tax compliance
DAMPAK LEVERAGE, LIKUIDITAS, DAN PERTUMBUHAN PENJUALAN TERHADAP PROFITABILITAS
Authors: Prima Dewi Sofia , Susanti Merry , Susanto Liana , Sufiyati
Published: February 2025

The purpose of this study is to obtain empirical evidence whether leverage has a negative impact on profitability, whether liquidity has a negative impact on profitability, and whether sales growth has a positive impact on profitability. The population is all manufacturing companies consistently listed on the Indonesia Stock Exchange during the 2016-2019 period. Purposive sampling was used as a sampling technique. The data is processed using EVIEWS. Research on 111 data shows that leverage has a negative impact on profitability, liquidity does not have a negative impact on profitability, and sales growth does not have a positive impact on profitability.
Keywords: profitability, leverage, liquidity, sales growth
Bifidobacterium longum e os impactos na saúde emocional através dos hábitos de vida
Authors: Onofre Maria Julia , Florencio Glauber Pimentel , Menezes Ralciane de Paula , Röder Denise Von Dolinger de Brito
Published: February 2025

A microbiota intestinal tem um papel crucial na saúde geral, incluindo a saúde mental. As cepas de Bifidobacterium longum são consideradas habitantes comensais do trato gastrointestinal e sua presença é associada a efeitos benéficos no humor e na redução da ansiedade. Objetivo: Avaliar a correlação entre hábitos de vida, composição da microbiota intestinal, em especial as cepas de Bifidobacterium longum, e a saúde mental em adultos. Metodologia: Um estudo transversal foi conduzido em Uberlândia, Minas Gerais, com 130 pacientes adultos. Amostras fecais foram coletadas e analisadas para a presença de Bifidobacterium longum. Dados sobre hábitos de vida e saúde mental foram obtidos por meio de questionários validados no Brasil. Resultados: A análise revelou que estilos de vida saudáveis, incluindo sono equilibrado, dieta balanceada e atividade física regular, estão positivamente correlacionados com a presença de Bifidobacterium longum e melhores indicadores de saúde mental. Os resultados sugerem que intervenções no estilo de vida podem modular a composição da microbiota intestinal, impactando positivamente ou negativamente na saúde mental. Conclusão: Promover hábitos de vida saudáveis pode ser uma estratégia eficaz para melhorar a saúde mental através da modulação da microbiota intestinal.
CHALLENGES FACED BY DAIRY FARMERS IN HALDWANI BLOCK OF NAINITAL DISTRICT
Authors: Monika Rawat  , Dr N.S Bisht
Published: February 2025

Haldwani block of Nainital district is highest milk contributor in Nainital district milk producers cooperative Society. Thus large number of dairy farmers ranging from young to middle to old are present and contribute in milk production. Present study was conducted in Haldwani block of Nainital district, with the objective to find challenges faced by dairy farmers of the study area. Study concluded that these farmers face many challenges like lack of green fodder, high price of concentrate mixture, unavailability of veterinary services e.tc. Furthermore lack of resource person to provide correct information regarding various aspect of dairy farming, was also one of the many constraints faced by milk producers of the area
PRINCIPLES OF ORGANIZATION AND FUNCTIONING OF THE JUDICIARY: THEORETICAL AND LEGAL ASPECTS AND INTERNATIONAL STANDARDS
Authors:   Institute of Law and Public Relations, Open International University of Human Development "Ukraine", Kyiv, Ukraine, Izuita Petro , Voitenko Bohdan ,   Institute of Law and Public Relations, Open International University of Human Development "Ukraine", Kyiv, Ukraine
Published: February 2025

The article examines the basic principles of organization and functioning of the judiciary enshrined in the Constitution of Ukraine, civil procedural law and regulations governing the judiciary. An important aspect is the principle of legality, which allows for an optimal balance between the powers of the court and the rights of a person seeking judicial protection. In addition, the author reveals the content of the principles of judicial activity, independence, autonomy, exclusivity and completeness of the judiciary, which ensure a balance between the powers of the court and the rights of persons seeking judicial protection. Particular attention is paid to the importance of ensuring a fair trial, access to justice and the right to a trial by a court established by law. The practical aspects of the application of this principle in Ukraine and at the international level are assessed, in particular through the case law of the European Court of Human Rights.Particular attention is paid to the principle of protection of rights, legitimate interests and freedoms, its statutory consolidation and correlation with the principles of fair trial, access to justice and international human rights standards. The author analyzes the European practice, including the judgments of the European Court of Human Rights, on the guarantees of the right to a court established in accordance with the law. The author draws conclusions about the need to comply with international standards in the administration of justice in Ukraine.
DESTABILIZING FACTORS IN SOCIAL SPHERE MANAGEMENT ARISING AS A RESULT OF DECENTRALIZATION
Authors:   Institute of Law and Public Relations, Open International University of Human Development "Ukraine", Kyiv, Ukraine, Poberezhny Oleg
Published: February 2025

The article analyzes the main problems that arise in the social sphere and in the management of the social service system in the context of decentralization of power in Ukraine. Decentralization, as an important stage of reforms, aims to increase the efficiency of management and improve citizens' access to social services. However, this process is accompanied by numerous challenges that can negatively affect the stability of the system.The essence of the main problems that arise in the context of decentralization is identified and characterized. Among them are the uneven development of regions, insufficient financial capacity of local authorities, as well as the lack of qualified personnel in the social sphere. These factors can lead to a decrease in the quality of social services and their accessibility for the population.The author proposes a model for classifying factors that can act as destabilizing elements in the process of decentralization. They are divided into economic, social, political and organizational. Economic factors include lack of funding and inefficient use of resources. Social factors include inequality in access to services and insufficient awareness of citizens about their rights. Political factors are associated with the lack of a clear strategy and coordination between different levels of government. Organizational factors relate to ineffective management mechanisms and insufficient integration between services.The emphasis is placed on the importance of applying an integrated approach to solving problems in the social sphere in the contextof decentralization, as well as the need to develop strategies to overcome the identified destabilizing factors. It is also determined that decentralization in Ukraine opens up new opportunities for improving the social services system. However, to achieve success, it is necessary to continue working on solving existing problems, strengthen cooperation between all participants in the process and stimulate the development of the social services market. This will ensure an adequate level of social protectionfor the population and realize the rights of each person to receive the necessary support.
POLITICAL COMMUNICATION AS A TOOL OF SCIENTIFIC DIPLOMACY
Authors:   Institute of Law and Public Relations, Open International University of Human Development "Ukraine", Kyiv, Ukraine, Dabizha Vira
Published: February 2025

Communication processes are not only the exchange of information between individuals or groups but also a complex interaction that forms the foundations of our society, culture, and politics. Over centuries, it has evolved, acquiring new forms and meanings, transforming according to the demands of time and human development. In the modern globalized world, communication processes interact as integral components of international relations, contributing to the effective resolution of global challenges. Political communication provides a platform for exchanging information between governments, scientific institutions, international organizations, and the public. At the same time, scientific diplomacy aims to foster international cooperation based on scientificknowledge, innovations, and joint research, supported by clear and transparent communication.By analyzing historical examples, concepts, and contemporary challenges, the goal is not only to outline the key aspects of this process but also to propose possible ways for the further development of communication as a foundation for harmonious coexistence and progress in the globalized world.With the emergence of multilateral international organizations, communication processes in the context of diplomatic decisions have evolved, contributing to the development of effective policies based on evidence and scientifically verified data. Implementing such decisions is critical for addressing contemporary global problems, such as climate change, energy security, pandemics, and technological development. Effective political communication within the framework of scientific diplomacy helps not only to transmit information but also to build trust, mobilize society, and engage it in active discussions on key issues.
ДЕРЖАВНА ІНФОРМАЦІЙНА ПОЛІТИКА ЯК ПРОТИДІЯ ЗАГРОЗАМ ІНФОРМАЦІЙНОМУ СУВЕРЕНІТЕТУ
Authors:   Open International University of Human Developmеnt «Ukraine», Kadlubovych Tetyana , Chernyak Daryna ,   Kyiv National University of Technology and Design, Kyiv, Ukraine
Published: February 2025

The article highlights the issues of state information policy, raises questions of information security and information sovereignty. It is noted that the foundation of information sovereignty should be a competent and balanced information policy of the state, based on legal principles and the principles of a democratic society. The scientific contributions of contemporary Ukrainian and foreign scholars are analyzed, who examine the principles of the information society, changes caused by informatization, virtualization, and digitalization of politics. The relevance of the topic is determined by the increasing threats to Ukraine's information sovereignty in connection with the full-scale aggression of the rf. The authors agree with the conclusions of researchers that information policy is one of the areas of state activity and is defined as a set of directions and methods of activity of state bodies in the field of obtaining, storing, processing, using, and disseminating information. The primary task of the state information policy is to ensure the information security of Ukraine. The way information is presented and its quality affect not only the internal components of societal life but also the image of the state on the international stage, its security, influence, and authority. Based on the views of American researcher S. Krasner, an attempt has been made to identify the levels of information sovereignty: the mega-level of information sovereignty is ensured by establishing mutually beneficial information connections on the international stage; the macro-level encompasses the activities of political institutions that implement information policy at the state level; the meso-level is the sphere of responsibility of local authorities, as well as the activitiesof local and regional mass communication media. It is noted that special attention should be paid to the micro-level of information sovereignty, as the entire population of the country is involved in its production. It has been concluded that information sovereignty depends on a competent information policy at the level of the individual, the state, society, and the international community as a whole.
OUTSOURCING AND OUTSTAFFING: LEGAL ASPECTS OF BUSINESS PROCESS OPTIMIZATION IN UKRAINE
Authors:   Institute of Law and Public Relations, Open International University of Human Development "Ukraine", Kyiv, Ukraine, Denysov Denys
Published: February 2025

The article examines the legal aspects of outsourcing and outstaffing as modern tools for optimizing business processes. The essence and key characteristics of these models, their impact on labor organization, and the efficiency of enterprises are analyzed. The author examines the essence of the concepts of “outsourcing” and “outstaffing”, their differences and main characteristics in terms of legal regulation. Particular attention is paid to the legal regulation of outsourcing in Ukraine and existing legislative gaps in the field of outstaffing. Special attention is paid to the legal framework governing these types of activities, including labor and civil law contracts. The author analyzes the current problems and risks associated with the engagement of external specialists, including issues of employee rights protection, taxation and liability of the parties. The main problems arising in the process of transferring functions to external companies are identified, especially concerning the social protection of employees and the responsibilities of the parties. Practical aspects of outsourcing and outstaffing in various business areas are highlighted. The article provides recommendations for improving the regulatory framework, including defining the legal status of outstaffing, creating a licensing mechanism for provider companies, and implementing guarantees for employees. The results of the study aim to increase the transparency of legal relations in the field of outsourcing and outstaffing, contributing to a balance of interests between employers and employees.
RISK-ORIENTED APPROACHES TO MANAGEMENT IN THE PROCESS OF ENSURING THE ENERGY SECURITY OF THE STATE
Authors:   State University of Trade and Economics,Kyiv, Ukraine, Koval Yana
Published: February 2025

Ensuring the country's energy security is one of the priority, but difficult for the public administration system, areas of national security1 , since management activities in this area require taking into account various aspects of the country's life. We are talking about resource, technical, economic, environmental, organizational, administrative, managerial, social, innovative, political, geopolitical, security, ideological and other aspects of energy supply for the vital needs of a person, society, business entities and the state. The vast majority of studies on assessing the state of energy security use a comprehensive approach, which, however, is not without some problems due to the predominantly arbitrary selection of groups of parameters that the researcher believes are important for analysis. The use of an integrated approach does not allow to develop a universal method for selecting parameters for assessing energy security for different countries and specific conditions of their energy markets. The purpose of the article is to analyze risk-based management approaches in the process of ensuring the energy security of the state.The study revealed a negative trend of risk growth at all hierarchical levels (in the groups of internal, corporate, domestic and supranational risks). It is established that in the long term, the activities of Ukrainian energy enterprises will largely depend on the trends in the functioning of the international energy market. The author proposes to integrate the concept of a risk-oriented approach to management into the process of ensuring energy security in order to improve the efficiency of management decision-making, achieve sustainable economic development, and stabilize and maintain a high level of the State's energy security.
Extraction of paraben from blue berries and separation by column chromatography
Authors: N Sruthi , S Asma Parveen , Y Prapurna Chandra
Published: February 2025

Parabens are naturally occurring phenolic compounds commonly found in fruits such as blueberries and are valued for their antimicrobial and preservative properties. This study aims to extract parabens from blueberries and purify them using column chromatography. The extraction was carried out using a methanol-water solvent system (80:20 v/v) to maximize the yield of parabens. The crude extract was filtered and concentrated before further purification. Solvent partitioning with ethyl acetate was performed to enhance the separation of parabens from other non-polar compounds. The concentrated extract was subjected to column chromatography using silica gel as the stationary phase and a hexane-ethyl acetate gradient system as the mobile phase. Fractions were collected systematically and analyzed for the presence of parabens using Thin- Layer Chromatography (TLC), with standard parabens as reference markers. Selected fractions containing parabens were further validated using High-Performance Liquid Chromatography (HPLC) and Gas Chromatography-Mass Spectrometry (GC-MS) for confirmation and quantification. The results demonstrated successful extraction and isolation of parabens from blueberries, with efficient separation achieved using column chromatography. The findings can contribute to the development of natural preservatives for use in pharmaceutical, cosmetic, and food industries, offering an eco-friendly alternative to synthetic parabens.
Two-Wavelet Multipliers and Applications
Authors: Ghobber Saifallah , Mejjaoli Hatem , Sraeib Nadia
Published: February 2025

This paper delves into the Dunkl-Bessel operator on and its corresponding harmonic analysis. A generalized form of Heisenberg-type uncertainty inequality is established. Schatten-von Neumann properties for the two-wavelet multiplier within the Dunkl-Bessel theory framework are elucidated. Additionally, the trace formula for a two-wavelet Dunkl-Bessel multiplier is proven as a bounded linear operator in the trace class from into . Furthermore, subject to appropriate conditions, the boundedness and compactness of these Dunkl-Bessel two-wavelet multipliers are proven, applicable to , 1 ≤ p ≤ ∞. Finally, using a class of concentration operators for the Dunkl-Bessel two-wavelet, we show that the eigenfunctions of the Dunkl-Bessel two-wavelet are maximally concentrated in the time-frequency domain. Leveraging this result, we derive approximation inequalities for functions that exhibit significant concentration within specific regions of the time-frequency plane.
Adopted Chebyshev Collocation Algorithm for Modeling Human Corneal Shape via the Caputo Fractional Derivative
Authors: Youssri Y. H. , Atta A. G.
Published: February 2025

To solve a fractional boundary value problem that simulates the dynamics of the human corneal shape, we offer a semi-analytic spectral collocation procedure. The boundary conditions are exactly satisfied by expanding the proposed approximation solution as a finite sum of certain basis functions, namely a combination of the first kind Chebyshev polynomials. Next, using the typical Chebyshev nodes, we use the spectral collocation method and find explicit forms of the first- and second-order derivatives in both integer and fractional cases. At various values for orders of the fractional derivative and model parameter values, we display a number of graphical outcomes. We study the convergence and truncation error analysis of the proposed expansion. This paper presents a semi-analytic spectral technique to solve a fractional boundary value problem modeling human corneal dynamics. Using the Caputo fractional derivative and Chebyshev nodes, the solution is expanded as a finite sum of compact basis functions, with spectral collocation employed to derive explicit first- and second-order derivatives. Numerical simulations and convergence and error analyses are provided at various fractional orders and model parameters.
Modeling, Control, and Simulation of a Common-Emitter Switched Amplifier with a Voltage-Variable Gain
Authors: Campos-Salazar José M. , Nicolás-Apruzzese Joan , García-Rojas Gabriel
Published: February 2025

A novel topology of a switched amplifier configured as a common-emitter voltage variable gain amplifier, along with the implementation of a control system aimed at regulating the output voltage is introduced in this article. A key focus of this work is addressing the challenge of output voltage regulation in the presence of variations in voltage gain caused by changes in the output load. The proposed topology integrates a standard common-emitter amplifier with an additional switch connected to the emitter terminal, which enables implementing an efficient control over the amplifier's voltage gain. The feasibility and operation of the presented system are satisfactorily evaluated through simulation studies.
Advertising Design based on Virtual Reality Technology
Authors: Zheng Fangfang
Published: February 2025

With the rapid development of computer simulation, amorphous display science and technology is not limited to cutting-edge research in the laboratory, but has penetrated all walks of life, bringing earth-shaking changes to people's daily life. In the field of advertising design, virtual reality technology provides a brand-new platform, which makes advertising design no longer just a continuation of graphic design or traditional video production, but an innovative way closely combined with user experience. By highly simulating the environment and situation of the real world, virtual reality advertising can create unprecedented visual effects and emotional experiences, thus greatly enhancing the brand's appeal and memory. This unique media form has undoubtedly had a far-reaching impact on the advertising market, which not only changed the consumption habits of consumers but also reshaped the communication relationship between advertisers and audiences. The purpose of this dissertation is to deeply analyze the development of web-based fantasy world technology and its far-reaching influence on advertising communication, and at the same time explore how to adapt to the new challenges and opportunities brought by virtual reality technology with innovative design ideas and methods. In this era of accelerating digitalization, we need to rethink the essence of advertising and the way of communication, to make better use of the potential of this emerging technology, promote the development of the advertising industry, and achieve more accurate and efficient communication goals. Through this paper's discussion, I hope to provide a new perspective for professionals engaged in the advertising industry to gain insight into market trends and find solutions for them to adapt to this emerging communication mode in future advertising design.
Genetic Property Rhetoric and the Public Domain
Authors: Fagundes David
Published: February 2025

Among the many themes that illuminate Jorge Contreras’s The Genome Defense, this Essay focuses on property. It considers the rhetorical role played by property in convincing both courts and the public that patenting genetic data was legally and ethically objectionable. This Essay begins by locating property—and public property—as a major theme in the dialogue surrounding the Myriad litigation. It then situates this rhetorical move in the context of property-talk generally, highlighting the distinctiveness of leveraging public rather than private ownership as a means of accessing moral intuitions. Finally, this Essay reflects on what the use of public property rhetoric in Myriad can tell us about how we talk and think about ownership, both public and private, and how that rhetoric can contribute to a more nuanced understanding of the institution of property.
Pengaruh Kepemimpinan Transformasional Dan Komunikasi Terhadap Kinerja Pegawai Melalui Kepuasan Kerja Pegawai Dinas Ketenagakerjaan Kota Makassar
Authors: Idrus Tasmin , Ridjal Syamsul , Djaharuddin Dharmawaty
Published: February 2025

Jenis penelitian ini adalah penelitian deskriptif dengan pendekatan kuantitatif. Sampel dalam penelitian ini sebanyak 54 orang atau jumlah keseluruhan Aparatur Sipil Negara lingkup Dinas Ketenagakerjaan Kota Makassar. Metode analisis data yang digunakan adalah analisis statistik deskriptif dan analisis jalur.
Hasil penelitian menunjukkan bahwa kepemimpinan dan komunikasi berpengaruh positif signifikan terhadap kinerja pegawai. Selain itu, kepuasan kerja terbukti memediasi hubungan antara kepemimpinan dan kinerja pegawai, meskipun tidak memediasi hubungan antara komunikasi dan kinerja. Penelitian ini memberikan wawasan penting mengenai pentingnya kepemimpinan yang baik dan komunikasi yang efektif dalam meningkatkan kinerja pegawai.
Strategic Directions of Socio-Economic Development of State in the Conditions of Globalization
Authors:   Leonid Yuzkov Khmelnytskyi University of Management and Law
Published: February 2025

The collection contains materials of participants of the VI International Scientific and Practical Conference “Strategic Directions of Socio-Economic Development of State in the Conditions of Globalization”, dedicated to the memory of Doctor of Economic Sciences, Professor, Honoured Worker of Science and Technology of Ukraine Vasyl Ivanovych Pyla. They highlight the research results of scientists and practicing specialists who deal with various aspects of economics and management.
The collection is intended for scientists and scientific-pedagogical workers of higher education and scientific institutions, students, postgraduate and doctoral students, practitioners, and a wide readership.
The Depiction ofTime andSpace inThe Works ofLi Munyol
Authors:   Researcher, Tashkent State University of Oriental Studies, Uzbekistan, Karimov Nodir
Published: February 2025

Lee Mun-Yeol witnessed three major social and political events that left an indelible mark on the history of the Korean people in the twentieth century: brief freedom, civil war, and ideological division. These three periods also saw fundamental changes inliterature, and the works produced acquired new features in form and content. Lee Mun-Yeol's work effectively deepened these changes by accurately describing the time and place of depiction, as well as artistically capturing the various issues of that eraand their impact on the inner world of man.
Breast cancer in Pakistan: evaluating the health crisis and the path forward for women's wellbeing
Authors:   M.Phil Health Biotechnology, Department of Biotechnology, Faculty of Chemical and Life Sciences Abdul Wali Khan University Mardan, Pakistan, Nouman Muhammad , Mahmood Hafiz Fazal ,   MPhil Medical laboratory Science, Khyber Medical university Peshawar, Pakistan, Ahmad Bashir ,   M. Phil Biochemistry, Abdul Wali Khan University Mardan, Pakistan, Shams Faiza ,   M.Phil Biotechnology, Abdul Wali Khan University Mardan, Pakistan, khan Saad Ahmad ,   BS Biotechnology and Genetic Engineering, Hazara University Mansehra, Pakistan, Ahmad Mian Waqar ,   M. Phil Biotechnology and Genetic Engineering, Hazara University Mansehra, Pakistan, Zeb Hassan ,   M.Phil Medical Lab sciences (MLS), Iqra National University Peshawar, Pakistan, Ahmed Malaika ,   M.Phil Biotechnology and Genetic Engineering, The University of Agriculture Peshawar, Pakistan, khan Abdul Qadeer ,   Department of Allied Health Science, Iqra National University Peshawar, Pakistan
Published: February 2025

Breast cancer (BC) is the most prevalent malignancy among women globally. Historically regarded as a disease affecting older, middle-aged women, recent years have seen a growing incidence of BC among younger females, a trend also observed in studies conducted in Pakistan. This paper reviews the mutant functions of tumor suppressor genes (BRCA1, BRCA2, p53, ATM, and PTEN), epigenetic alterations, and the role of estrogen receptors in breast cancer development. Additionally, we examine the current BC scenario in Pakistan, highlighting a notably higher incidence among younger women. Data from SKMCH and RC indicate that women aged 45-49 years exhibit the highest incidence rate of 45.42%. Limited studies have reported a high expression of ER, PR, and HER-2/neu in Pakistani women. Furthermore, the presence of the BRCA1 (c.1961dupA) mutation in Pakistan aligns with global findings. However, no comprehensive studies have been conducted to investigate epigenetic transformations in breast tumors within the Pakistani population. This critical area of research warrants further exploration to provide a more complete understanding of BC in Pakistan.
Pengaruh perbedaan level chicory dengan onggok yang difermentasi terhadap kualitas fisik dan pH
Authors: Rahim Halisa , Hidayat Rahmat , Mayasari Novi , Tanuwiria Ujang Hidayat , Setiawan Muhammad Ariana , Yanza Yulianri Rizki
Published: February 2025

Penelitian ini bertujuan untuk mengevaluasi pengaruh proporsi campuran onggok dan chicory terhadap kualitas fisik dan pH silase. Rancangan acak lengkap (RAL) 5 × 5 diterapkan dengan lima perlakuan: P0 (100% onggok), P1 (75% onggok + 25% chicory), P2 (50% onggok + 50% chicory), P3 (25% onggok + 75% chicory), dan P4 (100% chicory). Uji normalitas menunjukkan bahwa data tidak terdistribusi normal, sehingga analisis dilakukan menggunakan uji Kruskal-Wallis. Hasil menunjukkan bahwa proporsi chicory yang lebih tinggi berpengaruh signifikan terhadap kualitas fisik silase, termasuk parameter warna, tekstur, aroma, dan pH. Perlakuan P0 menghasilkan silase dengan warna yang kurang baik dan tekstur padat tanpa berlendir, sedangkan P4 menghasilkan silase yang lebih lembek dan berlendir. Nilai pH juga menunjukkan perbedaan signifikan, dengan P0 memiliki pH yang lebih rendah dibandingkan P3 dan P4. Temuan ini mengindikasikan bahwa komposisi campuran onggok dan chicory dapat mempengaruhi kualitas silase secara signifikan. Komposisi campuran onggok dan chicory yang paling optimal terdapat pada P3(25% onggok + 75% chicory)
Hubungan Faktor internal dengan respon pengolah gula aren terhadap teknologi mesin pengolahan modern
Authors: Haeriah Yayah , Mulyana Vega Chendra , Najmudin Asep , Edeng Edeng , Juliawan Wendi
Published: February 2025

The machine for processing sap into ant sugar is a new technology that will be a solution to meet increasing market demand, both in terms of quality and quantity. Age background, education level, experience as a processor and number of ownership as internal factors of the processor will influence their response to the machine technology for processing sap into ant sugar. This research aims to determine the relationship between internal factors and the processor's response to machine technology for processing sap into sugar. The research method used a verification survey, samples were taken from 6 people from 12 people processing sap into palm sugar in Nanggerang Village, Nyalindung Village, Cisewu District, Garut Regency. The results of the research show that the internal factors in the categories of age, level of education, business experience, and cumulative number of sugar palm trees owned are in the medium category. The processor's response is partially seen based on the processor's knowledge indicators which are in the medium category, attitudes are in the high category, experience and implementation are in the low category. The result is a Spearman Rank Correlation Coefficient (rs) of 0.43, meaning that the relationship between Internal Factors consisting of age, level of education, business experience, number of palm trees and the processor's response to the machine processing sap into ant sugar is 43%.
Analisis asam oksalat pada pembuatan asam sunti (Averrhoa bilimbi) berdasarkan variasi konsentrasi garam dan suhu pengeringan
Authors: HK Lenny Amelia , Putranto Kelik
Published: February 2025

Bilimbi (Averrhoa bilimbi) is a popular raw material in the production of asam sunti, known for its distinct sour taste. Oxalic acid, which is found in bilimbi, can affect the quality and safety of the final product. Asam sunti is a fermented product that involves a preservation process using salt, which not only adds flavor but also has the potential to alter the nutritional content of the raw material. This study aims to analyze the oxalic acid content in the production of asam sunti from bilimbi (Averrhoa bilimbi) with variations in salt concentration and drying temperature. The study uses an experimental method with variations in salt concentration (5%, 10%, and 15%) and drying temperature (40°C, 50°C, and 60°C) to determine their effects on the oxalic acid content. The results show that both salt concentration and drying temperature affect the oxalic acid content in asam sunti. The treatment with 15% salt concentration (a3) and 40°C drying temperature (b1) gave the best results because these two factors support each other in maintaining the oxalic acid content. The 15% salt concentration is high enough to improve preservation and drying, while the 40°C drying temperature is optimal for preventing the degradation of chemical components.
Dynamic modulation of spatial selection: Online and anticipatory adjustments in the flanker task
Authors: Villalonga Mercedes B. , Noyce Abigail L. , Sekuler Robert
Published: February 2025

To track the spatiotemporal dynamics of selective attention, we constructed four theory-driven variants of Eriksen’s flanker task. In each, subjects made speeded binary categorizations of target arrowhead direction while ignoring surrounding flanker arrowheads, whose direction was either congruent or incongruent to the target. Experiment 1 tracked the temporal evolution of target selection by systematically manipulating onset asynchrony between the target and flankers. In Experiments 2A and 2B, we increased flanker strength (both experiments) and reduced target strength (Experiment 2B only) at various times relative to target onset, exploring the effects of dynamic perceptual inputs on flanker congruency effects. Experiment 3 measured how uncertainty about stimulus location impeded spatial selection. Our findings demonstrate that spatial selection in the flanker task is dynamically modulated by both intra- and supra-trial factors.
Recurso tecnológico Aula Digital en la mejora de la lectura de diversos tipos de textos escolares
Authors: Espinoza Orizano Elizabeth Kely
Published: February 2025

Objetivo. Comprobar la efectividad del recurso tecnológico Aula Digital en el desarrollo de la competencia “lee diversos tipos de texto” en los niños y niñas del 4° ciclo de la Institución Educativa N.º 32140 Antonio Brack Egg de Ambo (Perú), 2022. Métodos. Fue un estudio de enfoque cuantitativo y se empleó el diseño cuasiexperimental. La población estuvo conformada por 54 estudiantes de la Institución Educativa y se empleó una lista de cotejo para evaluar el pretest y postest, empleándose además la prueba estadística t de Student. Resultados. Se pudo identificar que tanto en el grupo experimental como en el de control respondieron “sí” el 19,9 % y “no” el 80,1 %, con una diferencia entre ambos grupos del 60,2 %. El p-valor fue de 0,000, por lo cual se encuentra por debajo de la mínima signifcancia de error = 0,05; además, la media del postest del GE (16,80) fue mayor que la media del GC (11,60). Conclusión. Se confirma la efectividad del recurso tecnológico Aula Digital en el desarrollo de la competencia “lee diversos tipos de texto” en los niños y niñas, pudiendo por tanto afrmar que la aplicación de este recurso tecnológico mejora de manera signifcativa la competencia “lee diversos tipos de textos” en los niños y niñas.
Atonía Uterina: Complicaciones que desencadenan una Histerectomía Postparto en el “HTD”, Enero 2019 – Septimebre 2024
Authors: Redrobán Martínez Jessy Paulette , Sanabria Vera Charles Johnson
Published: February 2025

El estudio tuvo como objetivo principal el identificar los factores de riesgo de Atonía Uterina y su impacto en la necesidad de histerectomía postparto en el Hospital Teófilo Dávila entre Enero del 201 9 a Septiembre del 2024. La atonía uterina, una de las principales causas de hemorragia postparto, requiere a veces intervenciones quirúrgicas para preservar la vida materna. Se empleó una metología cuantitativa y descriptiva, con un enfoque no experimental de corte transversal, revisando historias clínicas para el analisis de los factores de riesgo predominantes y su relación con la histerectomía. Los factores identificados incluyen multiparidad, macrosomía fetal, parto prolongado, uso de oxitocina y edad avanzada. Los resultados evidenciaron que la incidencia de histerectomías disminuyó tras 2019, lo que sugiere una mejora en los protocolos preventivos, aunque hubo un leve aumento en 2024. Entre las complicaciones asociadas incluyen infecciones puerperales, necesidad de transfusión y recuperación prolongada. Esto resalta la necesidad de fortalecer los protocolos de prevención y la capacitación del personal médico para reducir la frecuencia de histerectomías y mejorar los resultados de salud materna.
Incorrectos Hábitos que Generan Hipertensión Mal Controlada en Adultos Mayores de 65 años en el Carmen – Manabí
Authors: José Andrés Guerrero Pachacama , Dayanara Michelle Loza Cedeño , Jessica Gabriela Cevallos Medranda , Ginger Briggitte Morales Castro , Yandri Jose Bermúdez Almeida
Published: February 2025

Este estudio examina los hábitos que contribuyen al mal control de la hipertensión en adultos mayores que asisten a Centros de Salud. Utilizando un enfoque cualitativo, exploratorio y fenomenológico, se realizaron entrevistas semiestructuradas con diez participantes (siete mujeres y tres hombres) de 65 años o más. Los hallazgos revelan diferencias significativas de género en los hábitos de vida. Las mujeres exhibieron principalmente un comportamiento sedentario, junto con una dieta alta en alimentos fritos y sodio y baja en frutas y verduras. Estos patrones se atribuyeron a limitaciones económicas, normas culturales y conciencia limitada sobre la salud. Los hombres informaron un historial de consumo excesivo de alcohol y tabaco en sus años más jóvenes y una baja participación en la actividad física fuera del trabajo agrícola. El estudio subraya el papel de los hábitos arraigados y los contextos sociales en el manejo de la hipertensión. Los resultados destacan la necesidad de intervenciones específicas, incluida la educación para la salud y programas comunitarios accesibles, para promover comportamientos más saludables y mejorar la calidad de vida entre los adultos mayores.
Construcción Sostenible en Tarapoto, Perú: Retos y Oportunidades en un Contexto Amazónico
Authors: Rocha Sandoval César Augusto , Ocrospoma Callupe Fanny Natalia , Navarro del Aguila Luz Claudia
Published: February 2025

La construcción sostenible en Tarapoto, Perú, se considera una respuesta importante a los desafíos ambientales y de desarrollo urbano en la región amazónica. Tarapoto, ubicada en la región tropical del Perú, enfrenta los desafíos de alta humedad, altas temperaturas y frecuentes lluvias, que requieren soluciones arquitectónicas que respeten el entorno natural y reduzcan el impacto ambiental. Este artículo examina las prácticas y estrategias de construcción sustentable utilizadas en la ciudad, centrándose en el uso de materiales locales, métodos de diseño bioclimático y el uso de energía renovable. A través de análisis cualitativos, que incluyeron entrevistas con arquitectos, ingenieros y constructores locales, así como investigaciones sobre proyectos existentes, se identificaron las oportunidades y barreras más importantes para la implementación de edificios sustentables en la región. Una de esas opciones es utilizar materiales locales como la madera, el bambú y el adobe, que no sólo se adaptan al clima tropical, sino que también contribuyen a la sostenibilidad ambiental e impulsan la economía local. Además, la combinación de sistemas de energía solar y estrategias de eficiencia hídrica se convirtió en una solución viable para reducir el consumo energético de la región y el impacto ambiental de las viviendas. Sin embargo, existen obstáculos importantes, como el alto costo inicial de las tecnologías sustentables, la falta de capacitación técnica de los profesionales locales y la limitada implementación de políticas públicas para promover edificios verdes. A pesar de estos desafíos, el futuro de la construcción sostenible en Tarapoto es brillante, siempre y cuando se promuevan políticas de apoyo, educación y colaboración entre los sectores público y privado. El estudio concluye que, a pesar de los desafíos económicos y sociales de la construcción sustentable en Tarapoto, las soluciones basadas en materiales locales y tecnologías renovables tienen un gran potencial para transformar el paisaje urbano de la región, ayudando a construir una ciudad más resiliente y responsable.
La Ruralidad y Brechas de Género en la Actividad Agrícola
Authors: González Lazalde Iván , Lechuga Nevárez Mayela del Rayo , Galván Ismael María Quetzalcihuatl
Published: February 2025

La actividad agrícola rural es un elemento fundamental para el desarrollo rural en donde la mujer actualmente está incursionando. El objetivo es analizar el contexto agrícola con perspectiva de género en el estado de Durango. La metodología utilizada tiene un enfoque cuantitativo, con un diseño descriptivo, explicativo, no experimental, correlacional y de corte longitudinal. La muestra de 242 unidades productivas familiares dirigidos por hombres y mujeres productores agrícolas. La técnica para la recopilación de la información fue la encuesta y como instrumento el cuestionario. Los resultados muestran una relación entre la edad, la educación y la posesión de tierras de cultivo entre hombres y mujeres; el análisis realizado a las variables demográficas edad y escolaridad; así como las variables de las características principales de sus UPF: total de hectáreas, nivel de capitalización, valor del tractor utilizado para su proceso productivo, así como el modelo de éste, determinó que no existen diferencias estadísticamente significativas entre las muestras de agricultores hombres y la muestra de agricultoras mujeres; las brechas de género en el acceso a la actividad agrícola se está reduciendo, sin embargo, aún existe disparidad en los diferentes factores usados para este estudio en donde la mujer sigue estando en desventaja.
Diagnóstico y Manejo de la Inestabilidad del Carpo. Revisión de la literatura
Authors: Vásquez Sandoval Marco Antonio , Salgado Tomaselly Jorge Gonzalo , Altamirano Condemaita Diana Carolina , Pintio Sangoquiza Nelson Stalin , Parra Ullauri Joel Alexander
Published: February 2025

La inestabilidad del carpo se puede definir como la falta de capacidad de dicha articulación en poder soportar cargas fisiológicas provocando las subluxaciones. De origen multifactorial y habitualmente difícil de diagnosticar. Debido a esto se presenta la clasificación Mayo logrando clasificar a la inestabilidad carpiana en cuatro categorías: disociativa, no disociativa, compleja y adaptativa. Uno de los métodos diagnósticos más eficaces es la radiología utilizando modalidades de imagen avanzadas como la tomografía computarizada y la resonancia magnética sin embargo un manejo adecuado del paciente y de sus resultados dependen directamente de la interpretación precisa del estudio de imagen. Si bien el tratamiento conservador puede ser efectivo en casos leves, las lesiones más graves, especialmente en la inestabilidad carpiana disociativa, requieren intervención quirúrgica para prevenir el deterioro funcional y el desarrollo de complicaciones a largo plazo.