bluuebunny/crossref_metadata_2025 huggingface dataset:
REMODELING OF THE DUCT SYSTEM OF THE RAT SUBMANDIBULAR SALIVARY GLANDS IN CHRONIC ETHANOL INTOXICATION
Authors: Shevchenko Kostyantyn V. , Yeroshenko Galina A. , Vilkhova Оlena V. , Kramarenko Denis R. , Yakushko Оlena S. , Yachmin Anastasiya I.
Published: October 2020

The aim: To determine the dynamics of changes in metric parameters of the duct system of rat submandibular glands in normal conditions and chronic ethanol intoxication. Materials and methods: 50 albino outbred rats were involved in the experiment. 10 animals were assigned in the control group, 40 animals – in the experimental group. Animals were sacrificed on 5, 9, 12 and 30 days by overdose of thiopental anesthesia. Pieces of the submandibular glands were embedded into epon-812 according to the conventional technique. Results: On day 5 of the experiment the lumen diameter of intercalated duct reduced by 9,15 % (р <0,05). The lumen diameter of the striated ducts was by 5,29 % significantly greater than the values in controls (р <0,05). The lumen diameter of the granular ducts reduced by 2,45 % (р <0,05). On day 30 of the experiment the height of the epithelial cells of the intercalated ducts was by 8,47 % significantly less (р <0,05), the height of the epithelial cells of the striated ducts was by 12,27 % less (р <0,05) and the height of the epithelial cells of the granular ducts was by 11,96 % less (р <0,05) than the values in controls. Conclusions: No recovery of parameters occurs by day 30 of the experiment, indicating the depletion of the secretory epithelium of the duct system, due to dystrophic changes caused by vascular disorder in the microvasculature.
IMPROVEMENT OF STUDENTS’ MORPHO-FUNCTIONAL DEVELOPMENT AND HEALTH IN THE PROCESS OF SPORT-ORIENTED PHYSICAL EDUCATION
Authors: Prontenko Kostiantyn V. , Griban Grygoriy P. , Bloshchynskyi Ihor G. , Melnychuk Iryna M. , Popovych Dariya V. , Nazaruk Viktor L. , Yastremska Svitlana O. , Dzenzeliuk Dmytro O. , Novitska Inesa V.
Published: October 2020

The aim is to investigate the influence of sambo wrestling classes on the level of morpho-functional development and health of students during their studying. Materials and methods: The investigation was conducted in Zhytomyr National Agroecological University in 2017–2019. Ninety four students (51 male and 43 female) took part in the research. Two experimental and two control groups were formed: EG1 (n=25) and CG1 (n=26) involved male students, EG2 (n=21) and CG2 (n=22) – female students. The classes of EG were held according to the authors’ methodology, the classes of CG – according to the current physical education program. The analysis of the indicators of weight, height, lungs capacity, handgrip test, heart rate, blood pressure, body mass index, life index, power index and Robinson’s index was performed. The interrelation of students of EG and CG was defined according to the health levels at the beginning and at the end of the investigation. Results: It is determined that sambo wrestling classes had a positive influence on the students’ muscles system improvement, increased lung capacity, reduced body mass, improved cardiovascular system, and improved health. Сonclusions: The improvement of the indicators of morpho-functional development and health of students during sambo wrestling classes will have a positive influence on their physical working capacity and the efficiency of their studying and future professional activities.
SEX STEROIDS AND ADIPOKINES IN MEN WITH PROSTATE CANCER AND THEIR RELATIONSHIP WITH OBESITY AND METABOLIC SYNDROME
Authors: Borowski Artur , Siemińska Lucyna
Published: October 2020

Prostate cancer is the most commonly diagnosed cancer among men in the world and in Poland it is the second cause of death in men suffering from cancer. Recent evidence suggests that obesity is associated with prostate cancer. Increased BMI correlates with aggressive disease and with higher risk of recurrence and mortality in prostate cancer patients. Obesity can promote the progression of prostate cancer through endocrine disturbances, mainly in sex steroids, through chronic inflammation resulting in altered production of adipokines, peripheral insulin resistance with hyperinsulinemia and oxidative stress. Diagnosis of metabolic syndrome can be used in the global assessment of prognosis in patients with prostate cancer. The aim of the paper is to present current state of knowledge about connections between obesity, metabolic syndrome, sex steroids and adipokines in men with prostate cancer.
CONSTITUTIONAL AND ADMINISTRATIVE ASPECTS OF THE UKRAINE’S MEDICAL CODE
Authors: Mishyna Natalia V. , Surilova Olena O.
Published: October 2020

The aim of this study is to show which aspects of Ukraine’s constitutional and administrative law should appear in Ukraine’s future medical code.
Materials and methods: The authors analyse five pieces of law or proposed law, including the 1996 Constitution’s provisions on health care, Law the Fundamentals of Health Protection and the main codes. The authors apply classical legal analysis to these laws – analyzing the first three chapters of the proposed medical code from a constitutional and administrative perspective. The other methods used by the authors are systemic, comparative and synergetic.
Conclusion: Ukraine needs a medical code incorporating international and European health care standards. Such a code will also further develop the country’s medical legislation. Yet the proposed project has many constitutional and administrative weaknesses.
NON-ST-ELEVATION ACUTE CORONARY SYNDROME DUE TO A TOTALLY OCCLUDED CORONARY ARTERY: A HISTORY OF TWO TWIN BROTHERS
Authors: Kern Adam , Bojko Krystian , Sienkiewicz Ewa , Zarzecki Artur , Bil Jacek
Published: October 2020

We present the image of two twin brothers aged 53. Within 18 months they both underwent acute coronary syndrome treated with percutaneous coronary intervention (PCI). This story shows that both twins had similar comorbidities (hypercholesterolemia and hypothyroidism) as well as the course of the acute coronary syndrome. Although in both cases the coronary artery was totally occluded (in one case – fresh occlusion, in the other – CTO), no STEMI presentation was observed. Therefore, thorough investigation is warranted in twins after the acute coronary syndrome in of them, even in case of no evident ischemia symptoms.
The experience of surgical treatment of the patients with extended cicatricial esophageal strictures
Authors: Boyko Valeriy V. , Savvi Serhii O. , Korolevska Alla Yu. , Bytyak Serhii Yu. , Zhydetskyi Vitalii V. , Novikov Yevhen A. , Surmanidze Robert O.
Published: October 2020

The aim of the researce was the improvement of treatment results of patients with extended post-burn esophageal cicatricial strictures.
Materials and methods: The treatment results are presented for 102 patients which were divided into two groups. In 49 patients with extended post-burn esophageal cicatricial strictures of the main group modified esophagoplasty were performed. Traditional esophagoplasty in 53 patients of the comparison group was performed.
Results: A trend was observed on reduction in both short-term and long-term post-operative complications and lethality. The comparative analysis showed statistically valid reduction in number of complications caused by radical surgery: in the main group the frequency of short-term post-operative complications was 10,2 %, in the comparison group – 45,3 %, the frequency of long-term post-operative complications being in the main group 8,2 %, and in the comparison group 26,4%. A trend was observed on reduction of both local and general complications, which may be explained by both peculiarities of the operative interventions with application of improved surgical treatment methods and by more efficient pre-operation preparation of the patients. Post-operative lethality level was 2,0 % in the main group, and 3,8% in the comparison group. Life quality parameters in the main group patients in the long-term post-operation period were statistically significantly better.
Conclusions: In patients with extended post-burn esophageal cicatricial stricture application of the proposed surgical tactics, modified method of single-step esophagoplasty and esophagoplasty as Step II of the surgical treatment for persons who have a formed contact gastrostomy is an efficient means for patients’ treatment improvement.
Clinical features of chronic bronchitis and genetic risk factors for the development of chronic obstructive pulmonary disease in adolescent smokers
Authors: Ilchenko Svitlana I. , Fialkovska Anastasiia O. , Koreniuk Olena S. , Yaroshevska Tatiana V. , Kramarenko Nataliia M. , Skriabina Kateryna V.
Published: October 2020

The aim is to study the clinical features of the course of CB in adolescent smokers and to study the genetic risk factors for the development of COPD.
Materials and methods: There were examined 40 adolescent smokers with CB, 30 never-smokers adolescents with CB and 37 healthy adolescents smokers (control group). The study included the collection of anamnesis, objective examination. calculation of the smoking index and the «pack/year», molecular genetic investigations.
Results: It was proved that smoking leads to the development of chronic bronchitis as early as adolescence and affects its course, increasing the frequency and duration of exacerbations. We identified an association of the 2G/2G genotype of MMP1 gene with the development of chronic bronchitis in adolescent smokers. The TT genotype of CYP1A1 gene may be considered as a possible sustainability factor for the development of chronic bronchitis in adolescent smokers.
Conclusions: The study of candidate genes for COPD in childhood and adolescence will facilitate the early detection of high-risk groups in the formation of this pathology, which will allow doctors to take the necessary preventive measures.
Morphogenesis of maxillary sinuses in infants, during early and first childhood
Authors: Kuzniak Nataliya B. , Fedoniuk Larisa Ya. , Pryshlyak Аntonina М. , Skyba Olena I. , Yarema Oksana M. , Dovgalyuk Alina І. , Penteleichuk Nataliya P. , Smiianov Vladyslav A.
Published: October 2020

The aim: To study the peculiarities of the structure and to see the development of maxillary sinuses in infants, during the early and first childhood periods of human ontogenesis. Materials and methods: The study of the peculiarities of the development and formation of the maxillary sinuses’ wall was carried out on 50 species of the upper jaws, turtles and sections of the head of the human corpses during different periods of ontogenesis (in infants, during early and first childhood) with the help of histological examination, preparation, CT scan, radiography and morphometry. Results and conclussions: In infants and during the early and first childhood periods of human ontogenesis in the MS there are changes in both quantitative and qualitative nature. In infants (10 days – 1 year), maxillary sinuse is located more lateral to the basis of the lower nasal concha. In this period, it begins to form its lower wall, which in the form of a narrow strip invaginates into the alveolar process. The growth of the sinus is due to the protrusion of the external wall in the direction of the zygomatic bone. The wall of the maxillary sinuse is covered with mucosa (respiratory mucous membrane), which is lined by pseudostratified columnar ciliated epithelium, which is located on the basement membrane. X-ray examination of maxillary sinuse in infants shows that it is a pear-shaped in the anterior projection. Clearly the following walls of the sinuses are visible: the upper, the lower, one, which is arched-shaped, the front and the median, which in lower part are crossed as arch to each other. Investigation of biological specimens of the maxillofacial area of the early childhood period (1-3 years) showed that maxillary sinuses in all specimens are determined more laterally to the basis of the lower nasal concha. Its vertical dimension is 7.5-8.0 mm, transverse – 5.7-6.0 mm, anterior-posterior – 13.9-14.5 mm. X-ray examination of maxillary sinuse in early childhood in the front projection shows that it has an oval shape. There are the following walls of the sinus: upper, lower, front and middle. The study of biological specimens of the facial area in the period of the first childhood (4-7 years) has been established that the configuration of maxillary sinuse is changing. All walls are determined, but the upper wall is rather short, and the front wall is narrow. The median wall has the most prominent development. On X-rays in the anterior projection, a slight extension of the maxillary sinuse is noted laterally. Therefore, one should thoroughly study the peculiarities of the development and structure of the walls of the maxillary sinuses in order to prevent the development of complications and to achieve the treatment of inflammatory diseases of the MS in an optimal term.
Influence of sanitary – domestic conditions in the rural settlements of dnepropetrovsk region on the peasants’ healh
Authors: Hryhorenko Luibov V. , Abramov Serhii V. , Baibakov Volodymyr M. , Digtiar Valerii A. , Lukianenko Dmytro M.
Published: October 2020

The aim: Implementation results of sociological survey to the practice of hygienic researches at the subjective estimation of the drinking water quality and sanitary conditions of people’s life.
Materials and methods: At our study was used standardized “Questionnaire survey about quality of piped drinking water, which enters to the building (apartment)”, which contained 25 questions. In the sociological survey were participated 150 respondents.
Results: Peasants of Dnepropetrovsk region considered that the following indicators of drinking water quality impact on their health: deterioration quality of piped drinking water, smell – 22.6%, color – 14.6 %, rust – 13.3 %, precipitate – 8.0 %, turbidity and suspended solids – 10.6 %, taste and aftertaste – 13.3 %, foam and impurities – 10.6 % (p<0.05). Some of peasants (14.6 %) have unsatisfactory sanitary conditions, living on 5 – 6 persons in 1 rooms flat (p<0.05).
Conclusions: Results of sociological survey shown that among rural residents increased the demand for a consumption of pre-treated drinking water, due to the deterioration quality of tap water in the rural area. It was determined, that increased frequency of use the bottled drinking water – daily it was used by 13 rural respondents (17.3%), once a week – 21 respondents (28%), 2-3 times a week – 8 respondents (10.6%).
Therapeutic tactics in the deep forms of rectal abscesses complicated by fournie gangrene
Authors: Kanikovskyi Oleh E. , Osadchyі Andrii V. , Androsov Sergey I. , Tomashevsky Anatolii V. , Yarmak Oleh A. , Bakhnivskyi Valentyn S.
Published: October 2020

The aim: To conduct an analysis of the complex treatment of severe forms of rectal abscesses complicated by NF.
Materials and methods: The results of treatment in 471 patients with deep forms of RA was performed. In 38(8%) the spread of the process and rotten-necrotic affection of the perineal fascia. Patients were treated at the surgical clinic of the medical faculty №2, VNPMMU, and Vinnytsya Clinical Emergency Hospital in the period from 2010-2018.
Results: Total lethality 8(1,7%). Mortality in GF was 8(19,5%). It is worth noting the reduction of the treatment duration against the background of the modern technologies usage in the period from 2016 to 12 days in relation to the total figure of 15 days.
Conclusions: Early surgical treatment, adequate necrectomy, fasciotomy and antibacterial therapy stop the necrotic process. The active aspiration reduces the timing of wound cleansing and further ensures the accelerated implementation of reconstructive surgical interventions.
Clinical and immunologic assessment of a complex of therapeutic-preventive measures concerning chronic catarrhal gingivitis in children with comorbid diabetes mellitus
Authors: Godovanets Oksana I. , Kotelban Аnastasiia V. , Moroz Petro V. , Vitkovskyi Oleksandr O. , Kitsak Tetiana S. , Navolskyi Nazar M.
Published: October 2020

The aim of our study is to increase the efficacy of treatment of chronic catarrhal gingivitis in children suffering from type 1 diabetes mellitus by means of improvement of the methods of pharmacological correction on the basis of investigation of clinical-immunologic peculiarities of the disease.
Materials and methods: 2 groups of the study were formed. Children received basic insulin therapy. The treatment of chronic catarrhal gingivitis in children from the main group were suggested the antiseptic solution “Decasan”; pill of a probiotic action “BioGaia ProDentis” and the immune modulator “Imupret”. Children from the comparative group were treated according to the common scheme.
Results: The state of the oral hygiene in all the children after treatment improved considerably. According to PMA index inflammatory process was completely eliminated in children from the main group. A similar tendency was observed concerning sextants with gingival bleeding. In children dental calculus was lacking after treatment. Lysozyme activity in the oral fluid of children after treatment increased approximately 37.50% in the main group, and 16,67 % – in the comparison group. A similar tendency was found concerning sIgА level.
Conclusions: Therefore, conducted course of the treatment concerning chronic catarrhal gingivitis promoted considerable improvement of the periodontal tissue in children.
Immunogenetic predictors of the development of bronchial obstruction during acute bronchitis in infants
Authors: Abaturov Alexandr E. , Rusakova Olena O.
Published: October 2020

The aim: To determine the most informative immunological and molecular genetic factors which reflect the characteristics of the inflammatory process and make it possible to predict the development of bronchial obstruction during acute bronchitis in infants. Materials and methods: 120 children aged from 6 months to 3 years old with acute bronchitis were examined. We determined NF-κB expression level in peripheral blood lymphocytes by flow cytometry method, the serum concentrations of interferon-γ, interleukins 4, 12 and 13 by ELISA, total IgE serum level by ECLIA and calculated the relative risk (RR) for each of these parameters. Results: The risk of bronchial obstruction development was high when the relative number of lymphocytes expressing NF-κB was under 49.8% (RR=3.27, 95% CI=2.09-4.92). IL-12 serum concentration from 41.35 pg/ml to 173.06 pg/ml (RR=5.35, 95% CI=2.82-9.15) and IL-13 serum concentration from 4.06 pg/ml to 6.71 pg/ml (RR=4.0, 95% CI=2.39-6.41) were early predictors of the appearance of wheezing during the disease. The probability of the development of bronchial obstruction was low when the relative number of lymphocytes expressing NF-κB was above 49.8% (RR=0.40, 95% CI=0.28-0.62). NF-κB expression level above 0.91 Units (RR=0.20, 95% CI=0.11-0.39), serum concentrations of IFN-γ above 9.83 pg/ml (RR=0.50, 95% CI=0.31-0.81), IL-12 above 173.06 pg/ml (RR=0.49, 95% CI=0.30-0.82), IL-13 above 6.71 pg/ml (RR=0.40, 95% CI=0.22-0.72) reduced the probability of the appearance of wheezing significantly. Conclusions: The development of bronchial obstruction during acute bronchitis in infants is associated with the relatively low NF-κB and IL-12 levels, imbalance in IFN-γ and IL-13 production.
Effective use of various minimally invasive technologies eliminating vertical reflux in the treatment of chronic diseases of the lower limb veins
Authors: Savolyuk Serhiy I. , Khodos Valentyn A. , Herashchenko Roman A. , Horbovets Vladyslav S.
Published: October 2020

The aim: To analyze and evaluate the efficacy of CDLLV treatment, using high-frequency endovascular welding (EVW), endovenous laser coagulation (EVLC) and catheter microfoam echosclerotherapy.
Materials and methods: We have treated 329 patients with CDLLV C2-C6 functional classes according to the Clinical Etiological Anatomical Pathophysiology. Of these, 102 patients had vertical reflux eliminated by EVW, in 112 – by EVLC, and in 115 – by catheter microfoam echosclerotherapy.
Results: In the EVW group 3 patients (2.94%) had a partial recanalization of coagulated veins 3 months after the procedure. In EVLC group 2 patients (1.79%) also had partial recanalization group after 6 months. In the group of catheter microfoam echosclerotherapy partial recanalization occurred in 3 patients during 3 months of observation, in the period of 6 months – in 2, in the period of 12 months – in 9, in total – in 14 patients (12.17%). The EVW and EVLC methods showed high efficacy of vertical reflux elimination on the great and small subcutaneous veins (GSV/SSV) in CDLLV and have no fundamental differences in the immediate and long-term results of treatment. Microfoam catheter echosclerotherapy leads to a greater number of recanalisations, compared with EVW and EVLC.
Conclusions: High-frequency endovenous welding results in complete fibrotic GSV/SSV transformation in 97.06% of patients. Endovascular laser coagulation results in complete fibrotic GSV/SSV transformation in 98.21% of patients. Elimination of vertical reflux by microfoam echosclerotherapy results in complete fibrotic GSV/SSV transformation in 87.83% of patients.
RESEARCH OF BIOLOGICAL PROPERTIES OF ENTEROVIRUS
STRAINS ASSOCIATED WITH ISCHEMIC STROKE
Authors: Andriushkova Natalia G. , Shyrobokov Volodymyr P. , Turchyna Nataliia S. , Melnyk Valentyna V. , Kuzminska Olena V. , Dolinchuk Ludmyla V.
Published: October 2020

Introduction: The research of biological properties of enteroviruses associated with ischemic stroke (IS) allows us to identify their intratypic differences.
The aim: to identify genetic markers of strains of enteroviruses associated with IS.
Materials and methods: 11 strains of enteroviruses isolated from the serum of patients with IS were identified in the virus neutralization test. Genetic markers of isolated
strains (Abent, marker S, marker rct40) were determined.
Results: Eleven strains of enteroviruses were isolated from the serum of patients with IS. Eight viruses: Coxsackie B viruses (serotypes 2, 3, 4) and ECHO viruses (serotypes 6, 9,
27 (two strains), 29) were identified in these strains. Other three strains of enteroviruses were unidentified.
Different combinations of genetic markers were found. Seven strains of enteroviruses (Coxsackie B2, B3, ECHO 6, ECHO 9, ECHO 27 (two strains) and one unidentified virus)
had virulence markers: Abent–, rct40+ and S−. Three strains (Coxsackie B4, ECHO 29, one unidentified virus) had markers: Abent–, rct40+, S+. Another one unidentified virus had
markers: Abent+, rct40+, S –.
Conclusions: All 11 isolates of enteroviruses associated with IS had rct40+ marker, 10 of the 11 isolates had marker Abent– and 8 of 11 isolates had marker S–. The research of
genetic markers allows to perform typic and intratypic differentiation of strains of enteroviruses associated with the IS.
SYNDROMAL CHARACTERISTICS OF THE COMBINED COURSE
OF CHRONIC PANCREATITIS AND ARTERIAL HYPERTENSION
Authors: Chubirko Ksenija I. , Horlenko Olesya M. , Bentsa Tetiana M. , Derbak Mariia A. , Tomey Adrian I. , Kossey Gabriella B. , Pushkash Lyubov Yu. , Brych Valeriya V. , Pushkash Ivan I.
Published: October 2020

The aim:To study the clinical course of chronic pancreatitis (CP) in patients with concomitant hypertension.
Materials and methods: A thorough analysis of the results of subjective and clinical and laboratory examinations of 102 patients with CP, who were hospitalized in the
therapeutic department of Khust district hospital during 2017-2018 was conducted.
Results: Takingintoaccount that the initial examination of patients was carried out during the period of exacerbation of the disease, all patients presentedwith pain syndrome
(100%).The overwhelming majority of patients identified pain as permanent aching discomfort in the abdominal cavity with periodic intensification (n = 41 (40,2%), 18
patients indicated burning pain (17,6%), 30 – cutting (29,4%) ), and 13 (12,7%) experienced pain of varying nature.due to the presence of hypertension (GC) 73 (71.6%)
patients complained of a headache of a paroxysmal periodic pulsating character, which was most often localized in the occipital-frontal area and was accompanied by dizziness,
“flickering of flies” before the eyes, noise in the ears. Also, 14 (13,7%) patients had shortness of breath at moderate physical exercise, lower extremity edema that appeared in
the afternoon and disappeared by the morning.In addition, 33 (32,4%) surveyed patients indicated a periodic heartbeat.In 18 (17,7%) patients sporadic dizziness was observed.
The level of blood pressure (BP), which was established in the studied patients, corresponded to arterial hypertension of grade 1-2 (154,15 ± 9,24 / 94,53 ± 9,05 mm Hg). In
terms of heart rate (HR) in the examined patients, it was 80.26 ± 10.73 beats per minute.
Conclusions: According to the study, the negative impact of concomitant hypertension on the clinical course of chronic pancreatitis was established, namely: hypertension in
most cases causes intensification of pain syndrome; pain syndrome in comorbid patients with cronic pancreatitis and arterial hypertension is accompanied by more pronounced
manifestations of asthenisation: general weakness, lethargy;dependence of the duration of pain syndrome from the height of blood pressure and the duration of arterial
hypertension was found; dyspepsia syndrome is more pronounced, varied and prolonged in patients with high blood pressure; smoking (37,3%), alcohol (19,6%), psychoemotional
overload (6,9%) are common etiologic factors in comorbid patients with chronic pancreatitis and arterial hypertension; BMI results indicate the dominance of excess
body mass in most comorbid patients with chronic pancreatitis and arterial hypertension.
STATISTICAL ANALYSIS OF THE IMPACT OF CLUSTERS
ON CARIES PREVALENCE AND INTENSITY IN CHILDREN
AGED 6-7 WITH DIFFERENT SOMATIC HEALTH STATUSES
Authors: Klitynska Oksana V. , Stishkovskyy Andriy V. , Hasiuk Natalia V. , Avetikov David S. , Ivaskevych Viktoria Z.
Published: October 2020

The aim: Determining the influence of cluster factors on the emergence and progression of caries in first- and second-grade children is appropriate in terms of determining
the most significant ones.
Materials and methods: The dental status of 73 children, residents of Uzhhorod, who study in the first grades of secondary schools, has been assessed, three groups have
been singled (the control group 26 healthy children). The indices of essential micro- and macronutrients in the hair, saliva, serum and urine, as well as anxiety level have been
determined and the statistical analysis has been performed.
Results: Decreased magnesium and calcium content in hair, serum, urine and mouth fluid, iodine is absent. Children of the third group have high levels of anxiety (80%), high
rates of caries (14,8) and significantly reduced levels of magnesium relative to normal.
Conclusions: In the patients of the main groups, a direct correlation was found between the presence of somatic pathology and the level of anxiety. In 80% of children of the third
group (CSPS≥3) the level of anxiety is high In the main group patients, a direct correlation was found between the presence of somatic pathology, the level of anxiety, and the decrease in
magnesium; The intensity of caries only interacts with a high level of anxiety (1.00), that is, in children who are in constant stress, the intensity of caries increases.
COMPARISON OF THE EFFECT OF DAPAGLIFLOZIN ON CONTRAST TO STANDARD THERAPY OF THE PATIENTS WITH TYPE 2 DIABETES MELLITUS AND CONCOMITANT OBESITY, THEIR EFFECT ON LABORATORY AND ANTHROPOMETRIC PARAMETERS
Authors: Griadil Taras I. , Chopey Ivan V. , Debreceni Kristian O. , Hechko Mykhaylo M. , Mykhalko Yaroslav O. , Feysa Snizhana V.
Published: October 2020

The aim: Evaluate clinical and laboratory parameters of the patients with type 2 diabetes mellitus and concomitant obesity after a course of dapagliflozin treatment and
compare with a standard treatment regimen.
Materials and methods: Conducted a comprehensive clinical laboratory examination and measurement of the anthropometric parameters of the patients with type 2 diabetes
mellitus and concomitant obesity, with subsequent statistical calculations.
Results: The data obtained at different stages of the study revealed a statistically significant effect of glucose treatment and glycosylated hemoglobin (HbA1c). Since the 6th
month of dapagliflozin treatment, we have shown a tendency to lose weight compared to baseline in this group of patients and controls.
Conclusions: Type 2 diabetes mellitus and obesity significantly increase the risk of developing a number of complications. Complex control and effects on clinical laboratory
and anthropometric parameters can statistically significantly influence the development of the complications, and in this context, dapaglifloflozin showed statistically better
results than standard metformin monotherapy.
CHANGES IN THE LEVEL OF α1-ANTITRYPSIN IN PATIENTS
WITH NON-ALCOHOLIC FATTY LIVER DISEASE
Authors: Sirchak Yelyzaveta S. , Griga Vasilij I. , Bedey Nelli V. , Pushkash Ivan I.
Published: October 2020

The aim: To investigate changes in the level of α1-antitrypsin (A1AT) in blood and in stool and their diagnostic value in patients with NAFLD and with impaired carbohydrate
metabolism at different stages of liver damage.
Materials and methods: 34 patients with non-alcoholic fatty hepatosis (NAFH) and 40 patients with non-alcoholic steatohepatitis (NASH) were examined. Enzyme-linked
immunosorbent assay for all patients with serum and coli was performed by determining the level of A1AT.
Results: In patients with NAFLD, in combination with IR, the level of A1AT in the blood plasma is only 1.6 times higher than that of the control group (p <0.05), and in the case
of combination of NAFH and type 2 diabetes mellitus (T2DM) – it is 2 times higher (p <0.05). In patients with NASH in combination with insulin resistance (IR), the level of
A1AT in the serum was 4.1 times higher than in the control group, and for NASH and type 2 diabetes – 4.2 times.
Conclusions:The level of A1AT in the blood plasma increases proportionally to the degree of progression of liver damage (from the minimum values at NAFH to the maximum
at NASH), regardless of the type of carbohydrate metabolism disturbance. The combination of NAFLD and T2DM is accompanied by a more pronounced increase in A1AT in stool
and α1-antitrypsin clearance than the combination of NAFLD and IR.
SUBSTANTIATION OF DIAGNOSIS AND TREATMENT OF CHRONIC
RECURRENT APHTHOUS STOMATITIS IN CROHN’S DISEASE
Authors: Feleshtynska Oksana Y. , Dyadyk Olena O.
Published: October 2020

The aim: To substantiate the diagnosis and treatment of chronic recurrent aphthous stomatitis in Crohn’s disease.
Materials and methods: The analysis of diagnostic and treatment of 52 patients with chronic recurrent aphthous stomatitis in Crohn’s disease (main group), mean age 31.8
+ 2.3 was performed. The comparison group consisted of 50 patients with chronic recurrent aphthous stomatitis not associated with Crohn’s disease (mean age 34.7 + 1.8).
Patients in both groups were studied for clinical manifestations, morphological and immunohistochemical studies the aphthae on the oral mucosa were performed.
Results: An objective evaluation of the oral mucosa showed that the aphthae on the oral mucosa in patients of both groups did not differ visually. In the morphological study,
the patients in the main group had granulomatous inflammation of the oral mucosa, characteristic of Crohn’s disease, while the patients in the comparison group had fibrinous
inflammation. Immunohistochemical study of the cell infiltrate phenotype in the area of the lesion revealed that the patients in the main group there prevailed CD68+macrophages,
the appearance of both intraepithelial and cell infiltrates of T-lymphocyte suppressors, which is characteristic of Crohn’s disease.
Conclusions: Diagnosis of chronic recurrent aphthous stomatitis in Crohn’s disease is based on biopsy of the aphthae on the oral mucosa and their morphological examination,
the results of which confirm the presence of granulomatous inflammation, with a large number of macrophages, the presence of T-lymphocytes, characteristic of Crohn’s disease,
while recurrent aphthous stomatitis of another genesis morphologically detect fibrinous inflammation.
The choice of therapeutic tactics for chronic recurrent aphthous stomatitis depends on the results of the morphological study. When granulomatous inflammation is detected in patients
with chronic recurrent aphthous stomatitis, which is characteristic of Crohn’s disease, in addition to topical treatment of the oral mucosa, specific therapy with mesalazine drugs is prescribed.
THE EFFECT OF THE PRESENCE OF EPILEPTIC ATTACKS ON THE CLINICAL DURATION OF SUPRATENTORIAL BRAIN MENINGIOMAS
Authors: Studeniak Taras О. , Smolanka Volodymyr І. , Borovik Olesya I.
Published: October 2020

The aim: To study the effect of epileptic seizures in patients with supratentorial brain meningiomas on the clinical course of meningiomas in the early and late postoperative period.
Materials and methods: A retrospective analysis of the course of the disease was performed in 242 patients with total removed supratentorial meningioma of the brain
(general group). Long-term outcome of the disease was estimated in 176 people (a catamnesis group).
Results: The occurrence of a new neurological deficit was observed in 18 (18.0±3.8 %) patients out of 100 among patients with epileptic seizures before surgery and in 19
(13.4±2.9 %) out of 142 among those who had no seizures. The mortality rate was 1 (1.0±1.0 %) in the group of patients with seizures and 3 (2.8±1.4 %) in the group of
patients without seizures before surgery.
The prevalence of new neurological deficits in the catamnesis group is 14 (19.2±4.6 %) of 73 patients with epileptic seizures before surgery and 17 (16.5±3.7 %) of 103 patients
without seizures. Mortality was 3 cases (4.1±2.3 %) in patients with seizures and 9 cases (8.7±2.8 %) among patients without seizures.
Conclusions: No data have been obtained that the presence of epileptic seizures affects the incidence of new neurological deficits, complications and mortality after surgical
treatment of meningiomas in the early and late postoperative period.
STATUS OF ADOLESCENTS WITH SYMPTOMS OF IRON DEFICIENCY IN UKRAINE
Authors: Matiukha Larysa F. , Perig Iuliia S. , Kononov Оleksandr Ye.
Published: October 2020

The aim: The purpose of this research was to study the reasons adolescents are underdiagnosed in iron deficiency in Ukraine.
Materials and methods: We provided a data analysis of medical records on the reasons and frequency of requests for medical assistance among teenage children, including
the age group10-19 years. The group of exclusion criteria included patients with traumatic brain injury, burns, eye diseases, congenital abnormalities of development, childhood
infirmities, persons who had contact with radiation, oncological patients, patients who had surgery within the last 3 months. Moreover, the researched cases were provided by
private medical institutions as we needed to compare the laboratory tests, which are not available in governmental primary care institutions. In this research were used such
key methods as basic data analysis, correlation-analysis and summarizing of gathered results.
Results: The number of referrals dominated initially to ENT (36.8%), family physicians (25.6%) and pediatricians (23.3%), with a nearly equal distribution of patients by gender.
From all the cases there were 162 cases where clinical laboratory blood test was performed (56,8% male, 43,2% female). The distribution among specialties of doctors, who
prescribed a blood test was: 64,2% family doctors , 9,3% ENT, 20,4% pediatricians, 6,1%- other specialists. Serum ferritin was discovered in 22 cases. They were found in 19,1%
and there was no correlation between inflammation changes and number of erythrocytes, hemoglobin and qualitative signs of red blood cells.
Conclusions: The analysis of medical records revealed the expediency of the syndromic distribution of causes of treatment, as well as the identification of risk groups and early
diagnosis of pathologies among adolescent children in the practice of a family doctor. A fifth part of adolescent patients appointments was made up of healthy individuals,
of whom (69.5%) belonged to the age group of 10-13 years. Inflammatory changes in the blood are not related to the amount of hemoglobin, erythrocytes and erythrocyte
characteristics. Hemoglobin, hematocrit and erythrocyte counts are not informative in the diagnosis of iron deficiency.
THE PSYCHOLOGICAL RESEARCH OF THE DOMINANT CONFIGURATION MODELS OF MARITAL RELATIONSHIPS OF A WOMEN WITH NEUROTIC DISORDERS
Authors: Sedykh Kira V. , Myshko Nadiia M. , Zozul Tamila V.
Published: October 2020

The aim: To study the psychological peculiarities of relationships in families of women with neurotic disorders.
Materials and methods: 30 women who received treatment in the neurotic unit of the A.F. Maltsev Poltava Regional Clinical Psychiatric Hospital and 30 mentally healthy women
have been examined. In the research the authors used a complex of interrelated and complementary general scientific and specific methods based on the systematic approach.
Results: There was a tendency for following types of marital interactions: dependent – 58% of couples, intermediate – 35% of couples. The emotionally-metaphorical type
of interpreting life events is inherent for 89% of women with neurotic disorders. Studying the types of relationships with a husbands demonstrated that women with neurotic
disorders perform ‘the role of victim’ – 30% (1,7689) and ‘the role of ‘burden’’ – 40% (1,7689) in their relationships.
Conclusions: The types of relationships with a partner of women with neurotic disorders are partly determined by the specifics of early parenting experiences.
DISCRETE LABORATORY AND MORPHOMETRIC MARKERS OF ATHEROSCLEROTIC LESIONS OF LOWER EXTREMITY VESSELS
Authors: Horlenko Olesya M. , Studenyak Viktoriya M. , Horlenko Fedir V. , Prylypko Lyubomyra B.
Published: October 2020

The aim: To investigate discrete laboratory and morphometric features of atherosclerotic lesions in patients with chronic ischemia of the lower extremities (CILE).
Materials and methods:The examined contingent consisted of 47 patients (age 56.32 ± 1.09 years) diagnosed with obliterating atherosclerosis of the lower extremities. The
study included determination of levels of Homocysteine, Folic acid, C protein, quantitative determination of circulating Endothelial cells (DEC) in blood plasma, and morphometric
study of DEC.
Results: Protein C levels are within the reference values (0.97 ± 0.12 mg / l. In 37 (78.7%) patients Hypoacidofoliemia (<3.0 mmol / l) was observed. Homocysteine levels
were clearly elevated in all patients. In the vast majority Hyperhomocysteinemia mild form (91.5%) was observed. The number of DEC in patients was -3.22 ± 0.39x105/l and
after compression –6.12 ± 0.21x105/l
Conclusions: Protein C levels were within the reference values (0.97 ± 0.12 mg / l); Folic acid levels in the vast majority (37 patients, 78.7%) were <3.0 mmol /l. Blood plasma
Homocysteine levels were clearly elevated in all patients. The mild form of Hyperhomocysteinemia (91.5%). was observed in the vast majority The number of DEC in patients
was -3.22 ± 0.39x105 and after compression –6.12 ± 0.21x105/l, which confirmed the presence of the endothelial dysfunction.
PECULIARITIES OF THE EFFECTS OF BILE ACIDS ON ATPASE ACTIVITY OF THE COLON MUCOSA IN PATIENTS WITH OVERWEIGHT AND IRRITABLE BOWEL SYNDROME
Authors: Ferents Iryna M. , Bychkova Solomiia V. , Bychkov Mykola A.
Published: October 2020

The aim is to investigate the effect of bile acids on the ATPase activity of the colon mucosa in patients with overweight and irritable bowel syndrome (IBS). Materials and methods: Completely examined 12 patients with IBS and overweight.We estimated the ATPase activity of colon mucous of the patients with IBSspectrophotometrically by determined the content of orthophosphate that was released after ATP hydrolysis. We studied the effect of 3-sulphate of taurolitocholate (TLC-S) on specific activities of Na+/ K+-ATPase, Ca2+-ATPase of endoplasmatic reticulum (EPR),Ca2+-ATPase of plasmatic membrane (PM) and basal Mg2+-ATPase of postmitochondrial subcellular fraction of colon mucous of the patients with IBS. Results: We establishedthe specific activities of Na+/K+-ATPase, Ca2+-ATPase of EPR,Ca2+-ATPase of PM and basal Mg2+-ATPase. Therewere(6.06 ± 1.61), (5.88 ± 1.19), (8.86 ± 1.56) (6.44 ± 2.02)μmol Pi/ mg protein per hour, respectively. TLC-S (50 μM) did not causedany change of Na+/K+-ATPase , as well as Ca2+-ATPasesactivities, but statistically significant increased activity of Mg2+-ATPase of postmitochondrial subcellular fraction of colon mucous of the patients with IBS by 4 fold. Conclusions: TLC-S increased basal Mg2+-ATPase in the postmitochondrial fraction of colon mucous of the patients with overweight and IBS, but had no effect on Na+/K+-ATPase and Ca2+-ATPases activities. It has been suggested that activation of basal Mg2+-ATPase under by TLC-S may indicates the role of the endo-lysosomal system of epitheliocytes of colon mucous in developing of pathology IBS.
USE OF TECHNOMOLECULAR SILVER PREPARATIONS IN COMPLEX TREATMENT OF INFECTED WOUNDS
Authors: Filip Stepan S. , Slivka Rudolf M. , Skripinets Yuriy P. , Bratasyuk Andriy M. , Fomenko-Luchinets Olena V.
Published: October 2020

The aim: To improve the results of treatment of infected wounds.
Materials and methods:The clinical material is based on clinical observation and treatment of 29 patients with in fected wounds, whose treatment included combination
drugs of local action on the basis of techno-molecular silver (in particular «Cadefort-Spray»), by application to the wound surface.
Results: Wound microbial factor, dynamics of wound process, indicators of immune status were evaluated: localadaptive immunity, atopic reactions.
Conclusions: High efficiency of treatment was observed regardless of the phase of the wound process, which allowed to accelerate wound repair and stimulate the processes
of regeneration, strengthen local adaptive immunity, prevent atopic reactions.
IMMUNOHISTOCHEMICAL AND GENETIC PROGNOSTIC FACTORS OF NEOADJUVANT CHEMORADIOTHERAPY EFFICАCY IN PERSONALIZED TREATMENT OF LOCAL ADVANCED RECTAL CANCER
Authors: Zvirych Vitalii V. , Michailovich Yuriy I. , Gorbach Oleksandr І. , Khranovska Natalia М.
Published: October 2020

The aim: The aim of our study was to define the factors that can robustly predict a response to neoadjuvant chemoradiotherapy (NCRT) in patients with local advanced rectal cancer (LARC) and prognosis factors of progression free survival (PFS) using molecular (8-oxodGu), immunohystochemical (Ki-67) and genetic (GSTP1 and MTHFR genes polymorphism) markers. Materials and methods: GSTP1 and MTHFR polymorphisms were studied by real-time PCR on tumour material from 110 patients with LARC. Ki-67 protein expression was assessed using rabbit monoclonal antibodies to Ki-67 (Dako, Denmark) on EnVisionTM FLEX detection system (Dako, Denmark). 8-oxodGu level in eluate was measured by spectrophotometry. Results: Patients from both groups showed significant pathomorphological response to NCRT. It is robust correlation between 8-oxodGu levels in patients’ blood and their response to CRT (mrTRG scale) in MG was determined. Oxaliplatin-containing chemotherapy promotes statistically significant decrease of 8-oxodGu levels. With the decrease of Ki-67 protein expression level the probability of tumour relapse increases. It is determined that critical value of Ki-67 protein expression level makes less than 27 and tumour relapse probability in this case makes 50%. Tumour relapse risk in patients with GSTP1 and MTHFR polymorphism is 12.3 and 16.3 times higher than in patients who do not carry such polymorphism, respectively. Combination of GSTP1, МTНFR polymorphisms and Кі-67 protein expression factors determines prognostic probability of tumour relapse within 51-99%. Conclusions: 8-oxodGu level can serve as independent prognostic factor of NCRT efficacy in patients with LARC. Combination of GSTP1, МTНFR genes polymorphism with Кі-67 protein expression decrease enables monitoring and robust prognosis of LARC relapse.
THE RIGHT TO CLONE: SOME ASPECTS OF THE CONTEMPORARY DISCOURSE
Authors: Potapchuk Anatoliy M. , Popovych Tereziia P. , Kostenko Yevhen Ya. , Baryska Yana O. , Levkulych Vasyl V.
Published: October 2020

The aim: The paper aims to analyze some aspects of the contemporary discourse which concern the determination of the content and specificity of the right to clone. It also
outlines the main trends in the development of legal regulation of cloning within international and national law and order.
Materials and methods: Methodologically, this work is based on the system of methods, scientific approaches, techniques and principles with the help of which the realization
of the research aim is carried out. There have been applied universal, general scientific and special legal methods.
Conclusions: Regarding the findings of the study it is necessary to note the following. First, if there is a shared negative vision of the feasibility of reproductive cloning in
general, which is enshrined in international and national legislation, the need for therapeutic cloning remains an unresolved issue. Secondly, medicine advances and accordingly
sees new perspectives and innovative developments in the field of therapeutic activity, in particular, related to the results of therapeutic cloning, which can help in the fight
against incurable diseases. Hence, there is the necessity of further research aimed at the improvement of the existing mechanisms for implementing therapeutic cloning, and
determining its limits and procedural aspects.
DIAGNOSTIC PROBLEMS ACCOMPANYING BRANHYOGENIC CANCER – A CLINICAL CASE
Authors: Matolych Uliana D. , Ushtan Svetlana V. , Pankevych Victoria V. , Horytska Kateryna V.
Published: October 2020

Tumours and tumorous lesions of head and neck account for 10% of all oncological pathologies. Branhyogenic cancer is found in 4.5% of patients with lateral cysts in the neck. The article highlights the results of research the clinical case of branhyogenic cancer, provide its clinical and morphological analysis. The aim of our work was to study the clinical case of bronchial cancer, providing clinical and pathomorphological analysis. Examination and treatment was conducted in accordance with the clinical protocol using the diagnostic criteria necessary for management of patients diagnosed with tumours and tumorous lesions in a particular clinical case. We applied ultrasound examination of the locus, angiography of head and neck vessels with tomohexol and with 3D reconstruction, histological examination of surgical specimens (macroscopy and microscopy). On the basis of clinical investigaton, ultrasound examination, angiography clinical diagnosis was formulated – lateral cyst on the left side of the neck. A radical surgical removal of the mass was conducted. Histopathological conclusion: there is a proliferation of cystic transitional cell epithelium with the locus of invasive squamous cell carcinoma in the cystic wall that suggests malignant transformation of bronchogenic cyst. Final diagnosis: branhyogenic cancer. Thorough examination and analysis of a clinical case demonstrates that the development of branhyogenic cancer, is histo-genetically associated with lateral cysts in the neck. Complexity of diagnosing and high percentage of malignancy induces to more early discovery and removal of lateral cysts in the neck .