bluuebunny/crossref_metadata_2025 huggingface dataset:
Profile of Antiviral and Antibiotic Prescribing in COVID-19 Patients in Bengkulu Indonesia
Authors: Muslim Zamharira , Deby Kadek , Candrawati Helena Julia , Jatiningsih Setiyati
Published: October 2024

Coronavirus Disease 2019 (COVID-19 ) is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus and has a fast spread rate. The treatment for COVID-19  was at the beginning of the pandemic, and until now, it cannot be determined with certainty, so various efforts have been made. Treatment can be in the form of antiviral therapy until the use of antibiotics given at the start of the pandemic. The aim of this study is to identify antiviral and antibiotic use patterns in COVID-19  patients at a government hospital in Bengkulu City, Indonesia. This research was conducted by retrospective collection using secondary data (Medical Records) of COVID-19  patients hospitalized at a Regional General Hospital (RSUD) Dr M. Yunus Bengkulu from June to September 2021. In this study, a sample of 232 patient medical records was obtained. Common symptoms in confirmed COVID-19  patients were weakness (76.29%), cough (67.67%), shortness of breath (65.52%), flu (43.10%), fever (42.24%), etc. In this study, the most comorbid disease was hypertension (10.34%). There are three types of antiviral prescribed for COVID-19  patients: Favipiravir (49.56%), Remdesivir (19.82%), and Oseltamivir (15.51%), but 15.08% of patients were not prescribed antivirals. The prescription of antibiotics in this study varied, Azithromycin (53.02%), Ceftriaxone (24.57%), Cefixime (18.53%), and several other types of antibiotics, while 9.91% of patients were not given antibiotics. Antiviral therapy for COVID-19  patients was Favipiravir, Remdesivir, and Oseltamivir. Favipiravir is the most widely used antiviral drug. Meanwhile, the most widely used antibiotic therapy for COVID-19  patients is Azithromycin.
Learning Application Model of Head CT Scan Image Evaluation for Health Human Resource Capacity Building
Authors: Saifudin Saifudin , Setiawan Agung Nugroho , Amalia Rizki
Published: October 2024

Background: CT image evaluation of head scan is one of the competencies in radiographic students including students in Radiographer education. Students must be able to analyze image quality, which includes anatomical criteria as well as diagnostic information of CT Scan images. This research is a pioneering effort to use AI in analyzing CT Scan images obtained retrospectively from Radiology Installations. Objective: the use of Artificial Intelligence as a learning application that can be utilized by radiography students in studying the accuracy of image intensity and automatic anatomical positioning in a head CT Scan Image analysis application. Method: The study used CT scan images that researchers collected and obtained retrospectively from the Radiology Installation. The use of Artificial Intelligence methods in accordance with the needs of research and development of Matlab Software is used in designing programs for applications. Results: In the aspect of object setting accuracy, the application can assess the accuracy of the position of the Head Object rotation or not and assess the intensity of the CT Scan image. The test accuracy value of this application is 97,78%, specificity is 100% and sensitivity is 94,45%. Conclusion: This application program can be used to increase the skills of radiographer students.
Design and Development of A Patient Lifter For Brachytherapy Procedures in Cervical Cancer Treatment
Authors: Kurniawan Rudy , BE Marsum , Masrochah Siti , Darmini Darmini , Kartikasari Yeti
Published: October 2024

The role of a patient lifter in brachytherapy is crucial for ensuring safe and efficient patient transfer during treatment. The use of fabric slings for patient transfer in brachytherapy at MRCCC Siloam Hospitals Semanggi is considered ineffective as it requires at least 6-7 medical staff to move a patient. The development of medical devices, such as brachytherapy patient lifters, is critical for maintaining safety, as any failure or malfunction can cause serious injuries to both medical personnel and patients. This study aims to design a brachytherapy transfer table and evaluate its effectiveness in minimizing physical strain on healthcare workers during patient transfers. Research methods implementing a rigorous development process is essential to minimize the risk of failure by ensuring that validation and verification activities are conducted objectively, reproducibly, and are well documented. This research introduces an approach based on the formal R&D Borg and Gall method for developing brachytherapy patient lifters. Results Functional tests demonstrated the overall success of the brachytherapy patient transfer table, with a 100% validity rating from five experts. The test results showed a significant value of 0.000, less than 0.05, indicating a significant difference between conditions before and after the design of the patient transfer table. The development of the brachytherapy patient transfer table has been highly successful and effective at MRCCC Siloam Hospitals Semanggi. The device also holds potential for further development in studies with larger sample sizes.
PENINGKATAN KUALITAS HIDUP MASYARAKAT BADUY MELALUI OPTIMALISASI ERGONOMI DALAM KEHIDUPAN SEHARI-HARI
Authors: Sartono Sartono , Naim Abu , Syamsudin Syamsudin , Sulistiyo Suryo , Hernadi Raden , Soerahman Soerahman , Sapriyadi Sapriyadi , Setiyani Irma
Published: October 2024

Abstrak 

Permasalahan pada masyarakat Baduy tidak menerapkan prinsip ergonomi dalam aktivitas sehari-hari, mereka mengalami kualitas hidup yang buruk. Ini berdampak pada tingginya risiko kesehatan dan efisiensi kerja yang rendah, yang pada akhirnya menghambat kesejahteraan masyarakat.Tujuan dari pengabdian masyarakat ini adalah untuk meningkatkan kualitas hidup penduduk Baduy melalui penerapan ergonomi yang optimal dalam kehidupan sehari-hari. Akibat penggunaan alat-alat dan postur kerja yang tidak ergonomis, masyarakat Baduy, yang terkenal dengan gaya hidup tradisionalnya, seringkali menghadapi masalah fisik. Program ini bertujuan untuk memperkenalkan prinsip ergonomi yang sederhana namun efektif. Observasi langsung, wawancara, dan demonstrasi penggunaan alat yang lebih ergonomis sesuai dengan kehidupan sehari-hari orang Baduy digunakan. Hasil pengabdian menunjukkan bahwa masyarakat lebih memahami pentingnya ergonomi dan bagaimana menggunakan teknik ergonomis dalam aktivitas sehari-hari seperti pertanian, kerajinan tangan, dan rumah tangga. Meningkatkan produktivitas, kenyamanan, dan risiko cedera di Baduy. Peningkatan ini akan mengurangi risiko cedera, meningkatkan produktivitas, dan membuat masyarakat Baduy merasa lebih nyaman saat bekerja. Selain itu, program ini memberikan peluang untuk pengembangan lebih lanjut dalam hal kesehatan dan kesejahteraan masyarakat Baduy melalui pendekatan ergonomi yang berkelanjutan. 

Kata kunci: Ergonomi, Kualitas Hidup, Kesehatan Kerja, Produktivitas.
Bioinformatics analysis of therapeutic targets for idiopathic pulmonary fibrosis and exploration of immune cell infiltration patterns
Authors: Lu Zhendong , Saddozai Umair Ali Khan , Fu Siyun , Zhu Lingqin , Wang Jinghui
Published: October 2024

Idiopathic pulmonary fibrosis (IPF) is a severe progressive lung disease characterized by fibrotic changes in lung tissue, with limited treatment options. This study analyzed gene expression data from three gene expression omnibus datasets (GSE2052, GSE53845, and GSE110147) using R and LIMMA to identify differentially expressed genes (DEGs) in IPF samples. We identified 215 DEGs, comprising 106 upregulated and 109 downregulated genes. Weighted gene coexpression network analysis revealed five gene modules, with the module eigengene yellow showing the strongest correlation with IPF. Functional enrichment analysis of 40 consensus genes in this module indicated their significant involvement in extracellular matrix (ECM) organization. Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed pathways related to protein digestion, cell adhesion molecules, and the advanced glycation end product–receptor for advanced glycation end product signaling pathway. Based on protein–protein interaction network analysis, collagen type XV alpha 1 chain (COL15A1) and collagen type VI alpha 3 chain (COL6A3) were identified as upregulated hub genes in IPF, which were regulated by microRNAs and transcription factors. Immune cell infiltration analysis showed significant changes in immune cell populations in IPF samples, with increases in memory B cells, plasma cells, and M0 macrophages and decreases in CD8 T cells, and resting natural killer cells. Potential drugs targeting COL15A1 and COL6A3 were predicted using multiple databases, revealing compounds such as (+)-JQ1, aristolochic acid I, and dexamethasone with promising binding potential. These findings suggest that COL15A1 and COL6A3 are central hub genes in IPF, are associated with ECM organization and immune response, and serve as therapeutic targets for IPF.
Patient-specific design and fabrication of a trapeziometacarpal joint orthosis using a computed tomography image-based finite element model
Authors: Beom Park Chan , Sup Hwang Ji , Sik Gong Hyun , Park Hyung-Soon
Published: October 2024

Osteoarthritis (OA) of the trapeziometacarpal joint (TMCJ) can be caused by biomechanical wear on the articular cartilage due to high joint contact pressure, leading to severe pain in the thumb. Static orthoses have been applied for treatment in the early stages of OA to immobilize the TMCJ in the comfortable posture without considering contact pressure at the TMCJ, resulting in a high failure rate of pain relief during splinting. To ensure successful treatment, it is desirable to immobilize the TMCJ in an optimal posture that minimizes biomechanical joint contact pressure. This paper presents a patient-specific TMCJ orthosis design for the optimal posture, based on joint contact pressure obtained from a computed tomography (CT) image-based finite element (FE) TMCJ model. The estimated pressure at the subject-specific optimal posture averaged 2.8E-3 MPa, which was lower compared to the average pressure of 3.2E-2 MPa at the non-optimal but comfortable posture. To maintain this subject-specific optimal TMCJ posture, the orthosis was designed based on individual hand geometries with three-dimensional (3D) printing technology. The 3D-printed orthosis was preliminarily evaluated by patients with moderate to severe OA, and all patients reported pain relief. The Visual Analog Scale (VAS) and Disabilities of Arm, Shoulder, and Hand (DASH) scores improved by 1.8  1.7 and 13.1  5.4, respectively. For orthotic treatment in clinics, the FE model-based TMCJ orthosis design for the subject-specific optimal posture is beneficial in achieving relief of pain caused by OA.
Miniature modelling while aiming for transplantation– Current challenges and future perspectives of lung bioprinting
Authors: Bovari-Biri Judit , Garai Kitti , Lovaszi Borbal , Vereb Zoltan , E Pongracz Judit
Published: October 2024

The development of three-dimensional (3D) lung organs or tissues using gravitational methods and bioprinting technologies shows great promise for producing lung tissue for research, pharmaceutical, and clinical applications. The advancement of innovative technologies can improve our understanding of lung diseases and, if necessary, enable the production of replacement lungs for transplantation. The development of functional organs-on-a-chip and disease-specific lung tissues could provide a deep understanding of the molecular mechanisms underlying lung diseases and aid the identification of drug targets. This knowledge has the potential to enhance our understanding of lung tissue regeneration processes and could lead to the development of more effective treatments for human lung diseases. So much so that lung transplants in most disease-induced cases would not be necessary, as the appropriate medications could induce regeneration of the damaged organ. This review highlights the importance of using a variety of materials, preparation methods, and sizes of lung tissues in 3D bioprinting technologies to understand lung function better, test for drug selection during therapy and eventually produce transplantable organs, if necessary. The review also emphasizes the need for improvements in legislation and guidelines for researchers aiming to achieve quality-assured biomanufacturing.
Evaluation of 3D bioprinted skin scaffolds in mice along with gold nanoparticles exposure
Authors: Wang Yi , Ma Xin , Wu Xu , Wang Shuaideng , Peng Peng , Tang Guozhang , Qin Xinya , Wang Xinmeng , Wang Chenwei , Zhou Jiangning
Published: October 2024

The progress in nanomedicine has sparked increasing concerns regarding its applications in interaction with biocompatible materials. Here, we assessed and optimized the 3D bioprinting technique by testing various printing parameters with multiple types of cells. Cell-laden scaffolds were designed, cultivated, imaged, and transplanted onto the dorsal skin of nude mice. The structure of bioprinted scaffolds retained its shape and dimensions with no cell migration between layers. Moreover, gold nanoparticles (GNPs) were intravenously administered to transplanted nude mice and aggregately deposited in the cell-laden scaffolds. Importantly, GNPs exhibited extensive accumulation in bioprinted scaffolds compared to natural skin and other organs in vivo. GNPs accumulated in the dermis of the transplanted scaffolds, while they stayed in the subcutaneous tissue of the natural skin with no permeation to the dermis, indicating a high absorption tendency of GNPs for artificial scaffolds. The results revealed the lack of similarity of the artificial skin scaffolds to natural skin, which may weaken its potential applicability as artificial skin substitutes. Furthermore, the absorption property of 3D bioprinted scaffolds suggested its potential employment as: (1) a redemption therapeutic method to absorb and excrete GNPs; (2) a strategy for targeting drug delivery of GNPs.
Faktor-Faktor yang Berhubungan dengan Kejadian Diare pada Balita
Authors: Mariyani  , Syafail Hamami Hanifa Amalin
Published: October 2024

Diare hingga kini menjadi masalah kesehatan masyarakat di negara berkembang. Penyakit diare merupakan salah satu penyebab kesakitan dan kematian anak di dunia. Diare menjadi penyebab kedua kematian pada anak di bawah Lima tahun. Beberapa faktor-faktor dapat berhubungan dengan kejadian diare pada balita. Diare dapat disebabkan oleh rotavirus yang menginfeksi lambung dan usus. Dan terdapat faktor lain yang menyebabkan diare adalah pengetahuan ibu, pendidikan ibu, perilaku ibu, kebiasaan mencuci tangan dan sanitasi lingkungan. Mengetahui faktor-faktor apa saja yang berhubungan dengan kejadian diare pada balita di RSUD Kota Bekasi tahun 2018. Penelitian ini menggunakan desain studi case control dengan metode pendekatan retrospective. Responden dalam penelitian ini adalah ibu yang mempunyai anak balita yang terkena diare maupun tidak terkena diare dalam 1 bulan terakhir yang sedang di rawat maupun yang berkunjung ke RSUD Kota Bekasi pada bulan April-Mei 2018. Pengumpulan data dilakukan dengan pengisian kuesioner. Hasil pengumpulan data akan diolah dan dianalisis dengan menggunakan SPSS 21.0. Jumlah responden dalam penelitian ini sebanyak 105 orang. Hasil analisis faktor yang berhubungan dengan kejadian diare pada balita, didapatkan ada hubungan antara perilaku ibu , kebiasaan mencuci tangan dan sanitasi lingkungan dengan kejadian diare pada balita (p value <0,05) dan tidak ada hubungan antara pengetahuan ibu dan pendidikan ibu dengan kejadian diare pada balita (p value > 0,05).
Indeks Massa Tubuh Berhubungan dengan Kualitas Tidur pada Mahasiwa Keperawatan di Universitas Indonesia Maju
Authors: Paramitha Riana , Shifa Nurul Ainul , Afrina Rina
Published: October 2024

Tidur merupakan suatu kebutuhan dasar pada manusia. Kurang tidur dapat menyebabkan berbagai masalah kesehatan. kualitas tidur yang buruk dapat disebabkan oleh faktor apa pun, salah satunya adalah IMT. Penelitian ini bertujuan untuk mengidentifikasi hubungan antara indeks massa tubuh dan kualitas tidur pada mahasiswa keperawatan. Penelitian ini merupakan kuantitatif dengan desain cross-sectional. Responden dalam penelitian ini adalah mahasiswa keperawatan semester 3 dengan indeks massa tubuh underweight dan overweight dengan teknik pengambilan sampel Total Sampling sebanyak 38 orang. Pengumpulan data dilakukan dengan pengisian kuesioner PSQI untuk mengukur kualitas tidur dan lembar observasi untuk mengukur IMT. Pengolahan data dengan program komputer SPSS menggunakan uji chi square. Mayoritas dari responden dalam penelitian ini berusia 19-20 tahun (89,5%) dengan mayoritas jenis kelamin perempuan (84,2%). Lebih dari separuh responden memiliki indeks massa tubuh overweight (63,2%) dan sebagian besar mengalami kualitas tidur buruk (55,3%). Hasil analisa uji chi square menunjukkan nilai Pvalue = 0,004 yang artinya terdapat hubungan antara indeks massa tubuh dengan kualitas tidur. Ada hubungan indeks masa tubuh dengan kualitas tidur pada mahasiswa keperawatan di Universitas Indonesia Maju
Kejadian Sindrom Burnout dengan Pelaksanaan Keselamatan Pasien pada Perawat Pelaksana di Instalasi Rawat Inap RSUD Dr. Chasbullah Abdul Madjid Kota Bekasi
Authors: Herawati Tri Mulia , Djubaedah Siti
Published: October 2024

Sindrom burnout yang dialami perawat dapat mempengaruhi kinerja di rumah sakit yang dapat disebabkan oleh karakteristik individu. Tujuan penelitian ini adalah untuk mengetahui hubungan karakteristik individu (usia, jenis kelamin, masa kerja, tingkat pendidikan dan status pernikahan) dengan sindrom burnout, selain itu untuk mengetahuin hubungan sindrom burnout dengan pelaksanaan keselamatan pasien. Desain penelitian cross sectional dilakukan selama dua minggu di akhir bulan juli sampai awal agustus 2018 untuk mengetahui gambaran karakteristik individu serta mengukur sindrom burnout dan pelaksanaan keselamatan pasien. Penelitian ini dilakukan di Instalasi Rawat Inap RSUD dr. Chasbullah Abdul Madjid Kota Bekasi. Dalam menentukan unit sampel digunakan teknik purposive sampling. Dari 106 responden perawat, sebanyak 37.7% perawat mengalami sindrom burnoutdan 36.8% gambaran pelaksaan keselamatan pasien buruk. Hasil uji chi-square antara masing- masing variabel yaitu p value> 0.05, baik karakteristik individu dengan sindrom burnout (usia p=0.300, jenis kelamin p=0.929, masa kerja p=0.951, tingkat pendidikan p=0.838, dan status pernikahan p=0.914), maupun sindrom burnout dengan pelaksanaan keselamatan pasien (p = 0,343). Namun ada kecendrungan pengaruh karakteristik individu dengan timbulnya sindrom burnoutdanpengaruh sindrom burnout dengan pelaksanaan keselamatan pasien. Karakteristik individu tidak memiliki hubungan yang signifikan dengan timbulnya sindrom burnout pada perawat, selain itu sindrom burnout juga tidak memiliki hubungan yang signifikan dengan pelaksanaan keselamatan pasien.
THE ROLE OF TECHNOLOGY IN THE ECONOMY IN THE DIGITAL ERA
Authors: Taufiqurokhman Muhammad Dzakwan
Published: October 2024

The purpose of this research is to analyze and explain the optimization of the role of collaboration and the role of technology in the economy in the digital era. The data of this study is MSMEs in SUKABUMI City with a population of 31,926 people and is used as a sample in this study as many as 100 business actors taken using a simple size web.raosoft.com with an error rate of 10%. The research method uses a quantitative research method, with a data collection method, namely the distribution of questionnaires through google-form of statements to respondents and interviews. Simple linear regression analysis is used as the analysis method in this study. The results of the study explained that there was a positive influence of technology on the economy in Sukabumi City with a large influence of 61.2% and 38.8% influenced by other variables.
Argon Plasma Coagulation for Proctitis: A Meta-Analysis
Authors: Fisca Syofi Arrasyi  , Saptino Miro
Published: October 2024

Background: Proctitis, encompassing various etiologies, significantly diminishes patient quality of life. Argon plasma coagulation (APC) has emerged as a potential therapeutic modality, yet its efficacy and safety profile remain to be fully elucidated. This meta-analysis aimed to rigorously evaluate the effectiveness and safety of APC across diverse proctitis subtypes.
Methods: A comprehensive search of PubMed, Embase, and the Cochrane Library databases was conducted, spanning 2013 to 2023, to identify pertinent studies. Randomized controlled trials (RCTs) and observational studies comparing APC with alternative treatments or placebo in proctitis management were included. The primary outcome was clinical improvement, defined as symptom reduction or amelioration of endoscopic findings. Secondary outcomes encompassed adverse events and quality of life metrics.
Results: A total of 15 studies (5 RCTs and 10 observational studies) encompassing 2042 patients met the inclusion criteria. APC demonstrated a significant association with clinical response improvement compared to other treatments or placebo (OR 2.58, 95% CI 2.14-3.12, p<0.001). Subgroup analysis revealed APC's efficacy in both radiation-induced and non-radiation-induced proctitis. Adverse event incidence was comparable between APC and other treatments, with no significant differences in severe complications.
Conclusion: APC appears to be an effective and safe therapeutic option for various proctitis subtypes, warranting consideration in clinical practice.
Development of a telemedicine network for early oral cancer diagnosis: the Argentine Patagonia experience—a perspective through a pilot study
Authors: Andrian Romina , Müller Astrid , Pimentel Solá Juan Martin , Molina Ávila Ignacio , Gilligan Gerardo
Published: October 2024

Geographic areas like Argentine Patagonia face significant barriers in the fight against oral cancer due to great distances, extreme weather conditions, and a shortage of specialists. These factors contribute to delayed diagnosis and treatment, adversely affecting patient outcomes. The aim of this study was to describe a pilot project to establish the telemedicine network of Chubut (Argentine Patagonia) for the early diagnosis of oral cancer. This perspective study also aimed to describe the advantages and disadvantages of using this tool in remote areas with limited access to healthcare services. Healthcare professionals, including nurses, dentists, doctors, and healthcare workers, were trained in the early diagnosis of oral cancer and high-risk oral lesions by five specialists in Oral Medicine, who traveled throughout Argentine Patagonia. Additionally, training was provided on the use of smartphones to obtain clinical images and data for remote consultations via telemedicine with a specialized center. Over 2,000 km were traveled, and more than 100 healthcare professionals were trained in six towns and localities in Patagonia, Argentina, encountering various limitations for the use of telemedicine in remote areas, such as connectivity issues. The first telemedicine network of Patagonia for the diagnosis of oral cancer was created and is now operational, receiving teleconsultations and referrals from the professionals trained during the journey. This study highlighted that telemedicine is an important tool to overcome geographical barriers and improve access to medical care, especially in remote areas. It promotes agility and speed in referrals and optimizes the available resources of the health system. Future studies should analyze the impact of telemedicine in decreasing the delay of oral cancer diagnosis in Southern Argentina.
INTERTEXTUALITY AS A MEANS OF EXPRESSING DOMINANT MEANINGS IN DAVID LODGE’S CAMPUS NOVEL ‘THE BRITISH MUSEUM IS FALLING DOWN’
Authors:   Polzunov Altai State Technical University, Kremneva A. V. , Bobrovskaya N. A. , Kremleva Yu. V.
Published: October 2024

The article is related to the study of intertextuality as a means of generating and expressing meanings in fiction text. The intertextual analysis of David Lodge’s campus novel ‘The British Museum is Falling Down’ proved that an intertext can act not only as a means of creating language game, parody, pastiche, irony and comedy, but also, due to its double reference, as a means of generating and expressing new meanings, including the novel’s dominant meanings.
IAN MCEWAN’S IRONIC PERSPECTIVISM
Authors:   Samara National Research University named after Academician S. P. Korolev, Rozanov M. A.
Published: October 2024

Ironic perspectivism defined in this article as artistic reflection on the boundaries and possibilities of overcoming limitations is a significant phenomenon for English literature at the turn of the 20th and 21st centuries. It is embodied primarily in the study of forms of non-ironic consciousness, limited by confidence in its own positions and not attempting or unable to go beyond them and comprehend its relationship with the world. The aim of the article is to determine the specifics of ironic perspectivism in I. McEwan’s novels based on the material of the works «Amsterdam» and «Atonement». It is shown that the writer’s main poetological principle is the collision of non-ironic consciousness with something that does not fit within its boundaries, and the exploration of the reasons why the bearer of such consciousness finds himself in a deadlock. In the novel Amsterdam, I. McEwan explores the non-ironic consciousness of a person devoid of a value basis and hiding from himself an inner emptiness. Such a person experiences anxiety, as he does not feel genuine confidence in his positions, but, feeling the need for it, convinces himself of the reliability of his values, rejecting other views and putting on the mask of who he would like to see himself as. I. McEwan portrays a person who has abandoned a critical look at himself and, because of this, is unable to see the values that will allow him to build a full-fledged relationship with the Other. Exploring in the novel “Atonement” the forms of non-ironic consciousness, I. McEwan examines the possibility of overcoming human limitations that appeared due to fiction. The destructive rigoristic morality of the thirteen-year-old Briony’s consciousness is overcome by the form of the novel in the novel due to an excess of the author’s vision, which is able to explore human boundaries and suggest the possibility of liberation from these limitations.
THE CONCEPT «PATRIOT» IN ADVERTISING POSTS FOR RUSSIAN YOUTH (BASED ON PUBLICATIONS FROM THE ROSMOLODEZH OFFICIAL TELEGRAM CHANNEL)
Authors:   Moscow State Psychological and Pedagogical University, Astashina M. S.
Published: October 2024

This article is devoted to the study of the concept PATRIOT in advertising posts aimed at forming patriotic beliefs among Russian youth. The author analyses the lexical and stylistic techniques used by the writers of advertising texts in the social network Telegram to create the image of a patriot in the minds of the target audience (Russian youth). As a result of the research the author identifies the main linguistic strategies and means by which the concept «patriot» is formed in the addressees of advertising texts.
PUSHKIN’S “EGYPTIAN NIGHTS”: POET IN THE ROLE OF CLEOPATRA
Authors:   Independent Researcher, Pimonov Vladimir
Published: October 2024

This article explores Pushkin’s “Egyptian Nights,” which critics consider to be an unfinished work. For the first time, the analysis of the story’s plot structure is carried out exclusively in regard to the autograph draft in prose without taking into consideration the poetic improvisations which are absent in the poet’s manuscript, but are traditionally inserted by publishers into the printed text. The author argues that the story’s plot design is completed in Pushkin’s prose text. An allusive parallel between the story of Cleopatra and the story of the improviser based on the motifs of “prostitution” and the “severed head”, is described. It is shown that the plot structure of the story is built on the juxtaposition of two narrative levels: symbolic and real. In contrast to the ancient legend, in which the public (lovers) pay for the love of the Egyptian queen with their heads in a literal sense, in the main plot the improviser pays for the love of the public with his head in a figurative sense.
THE LITERARY GROUP «THE SERAPION BROTHERS» IN THE COMPREHENSION OF K. A. FEDIN
Authors:   State Museum of K.A. Fedin, Grigoryeva M. V.
Published: October 2024

The article is devoted to the study of K. A. Fedin’s attitude to the literary group “The Serapion Brothers”, of which he was a member. Ego-documents from the writer’s archive ‒ diaries and letters of 1921‒1966, including those not published earlier ‒ are involved in the analysis. The questions related to the assessment of the influence of the Serapions on Fedin’s work, as well as his perception of key moments in the history of the brotherhood are considered.
A COMPREHENSIVE APPROACH TO PUBLISHING FOLKLORE MONUMENTS: FROM THE EXPERIENCE OF PREPARING A 25-VOLUME ACADEMIC PUBLICATION «TATAR FOLK ART»
Authors:   G. Ibragimov Institute of Language, Literature and Art Academy of Sciences of the Republic of Tatarstan, Minnullin K. M. , Davletshina L. Kh.
Published: October 2024

This article is devoted to the experience of systematization and publication of folklore, implemented in the academic publication “Tatar Folk Art” in 25 volumes. The paper substantiates the need for an integrated approach based on the most syncretic nature of folklore and the state of modern folklore studies. Having analyzed the features of the classification of folklore texts containing mythological representations of the Tatars and data from the ritual tradition, the authors conclude that only with such a methodological approach folklore can be revealed in all its diversity as a single ideological complex.
Current strategies for predicting post-hepatectomy liver failure and a new ultrasound-based nomogram
Authors: Gao Xing-Xue , Li Jun-Feng
Published: October 2024

Liver cancer is associated with a few factors, such as viruses and alcohol consumption, and hepatectomy is an important treatment for patients with liver cancer. However, post-hepatectomy liver failure (PHLF) is the most serious complication and has a high mortality rate. Effective prediction of PHLF allows for the adjustment of clinical treatment strategies and is critical to the long-term prognosis of patients. Many factors have been associated with the development of PHLF, so there is an increasing interest in the development of predictive models for PHLF, such as nomograms that integrate intra-operative factors, imaging and biochemical characteristics of the patient. Ultrasound, as a simple and important examination method, plays an important role in predicting PHLF, especially the Nomogram established based on ultrasound measurements of liver stiffness and spleen area provides a more convenient way to predict the occurrence of PHLF.
Perianal Crohn’s disease: Still more questions than answers
Authors: Swaminathan Akhilesh , Sparrow Miles P
Published: October 2024

In this editorial we comment on the article by Pacheco et al published in a recent issue of the World Journal of Gastroenterology . We focus specifically on the burden of illness associated with perianal fistulizing Crohn’s disease (PFCD) and the diagnostic and therapeutic challenges in the management of this condition. Evolving evidence has shifted the diagnostic framework for PFCD from anatomical classification systems, to one that is more nuanced and patient-focused to drive ongoing decision making. This editorial aims to reflect on these aspects to help clinicians face the challenge of PFCD in day-to-day clinical practice.
Efficacy and safety of low-dose tetracycline, amoxicillin quadruple therapy in Helicobacter pylori infection: A retrospective single center study
Authors: Zhao Yi-Ru , Wang Xin-Jie , Zhu Meng-Jia , Chen Ang-Li , Zhang Dian , Du Qin , Kim John J , Hu Wei-Ling
Published: October 2024

BACKGROUND

Helicobacter pylori (H. pylori ) eradication rates have declined with the rise of antibiotic-resistant strains in recent years. Although highly effective with a low prevalence of resistance, standard dose tetracycline is associated with frequent adverse events. The efficacy and safety of low-dose tetracycline as part of tetracycline and amoxicillin-containing bismuth quadruple therapy are not well described.

AIM

To compare the efficacy and safety of low-dose compared to standard dose tetracycline with combined amoxicillin-containing bismuth quadruple therapy in patients with H. pylori infection.

METHODS

Consecutive patients with H. pylori infection receiving tetracycline, amoxicillin, proton pump inhibitor, and bismuth for 14 days at Sir Run Run Shaw Hospital (1/2022-6/2023) were evaluated. The low-dose tetracycline group received tetracycline 500 mg twice daily (bid) while the standard dose group received 750 mg bid or 500 mg three times daily (tid). Primary endpoints were H. pylori eradication rate and treatment-related adverse events.

RESULTS

The mean age of the 218 patients was 48.7 ± 14.0 years, 120 (55%) were male, and 118 (54.1%) received treatment as primary therapy. Furthermore, 73 (33%) patients received low-dose tetracycline (500 mg bid) and 145 (67%) received standard dose tetracycline including 500 mg tid in 74 (33%) and 750 mg bid in 71 (33%). On intention-to-treat analysis, H. pylori eradication rates were 89% [95% confidence interval (CI): 82%-96%] in the 500 mg bid group, 82% (95%CI: 74%-91%) in the 500 mg tid group, and 79% (95%CI: 69%-89%) in the 750 mg bid group without a statistically significant difference (P = 0.25). The incidence of adverse events was lower in the low-dose compared to the standard dose group (12.3% vs 31.1% or 23.9%; P = 0.02).

CONCLUSION

Low-dose tetracycline combined with amoxicillin quadruple therapy for 14 days achieved a high eradication rate and fewer adverse events compared to the standard dose tetracycline regimen in patients with H. pylori infection.
Advances in the research of intestinal fungi in Crohn's disease
Authors: Kong Mo-Wei , Yu Yang , Wang Peng , Wan Ying , Gao Yu , Zhang Chun-Xiang
Published: October 2024

This article reviews of the original research published by Wu et al in the World Journal of Gastroenterology , delving into the pivotal role of the gut microbiota in the pathogenesis of Crohn's disease (CD). Insights were gained from fecal microbiota transplantation (FMT) in mouse models, revealing the intricate interplay between the gut microbiota, mesenteric adipose tissue (MAT), and creeping fat. The study uncovered the characteristics of inflammation and fibrosis in the MAT and intestinal tissues of patients with CD; moreover, through the FMT mouse model, it observed the impact of samples from healthy patients and those with CD on symptoms. The pathogenesis of CD is complex, and its etiology remains unclear; however, it is widely believed that gut microbiota dysbiosis plays a significant role. Recently, with the development and application of next-generation sequencing technology, research on the role of fungi in the pathogenesis and chronicity of CD has deepened. This editorial serves as a supplement to the research by Wu et al who discussed advances related to the study of fungi in CD.
Gut microbiota in gastrointestinal diseases: Insights and therapeutic strategies
Authors: Jiang Lu , Fan Jian-Gao
Published: October 2024

Considering the bidirectional crosstalk along the gut-liver axis, gut-derived microorganisms and metabolites can be released into the liver, potentially leading to liver injury. In this editorial, we comment on several studies published in the recent issue of the World Journal of Gastroenterology . We focus specifically on the roles of gut microbiota in selected gastrointestinal (GI) diseases that are prevalent, such as inflammatory bowel disease, metabolic dysfunction-associated steatotic liver disease, and hepatitis B virus-related portal hypertension. Over the past few decades, findings from both preclinical and clinical studies have indicated an association between compositional and metabolic changes in the gut microbiota and the pathogenesis of the aforementioned GI disorders. However, studies elucidating the mechanisms underlying the host-microbiota interactions remain limited. The purpose of this editorial is to summarize current findings and provide insights regarding the context-specific roles of gut microbiota. Ultimately, the discovery of microbiome-based biomarkers may facilitate disease diagnosis and the development of personalized medicine.
High Prevalence and Impact of Shoulder Pain Among Gym Instructors: A Study on Work-Related Musculoskeletal Disorders
Authors: Shreya Misal  , Eden Mehdiabadi  , Albin Jerome
Published: October 2024

INTRODUCTION :- Gym instructors within the fitness industry play a pivotal role in guiding individuals towards achieving a range of health and fitness goals. In addition to muscular and skeletal health, gym instructors are instrumental in boosting the immune system. Even though they help in maintaining the body gym trainers have a limited knowledge of mechanism of injury, neglecting and repetitive movements of the joint leads to worsening of injury and increase in the pain. Musculoskeletal pain can stem from  various sources, including uncommon or repetitive activities that strain muscles, tendons, and ligaments. Additionally, it may result from sudden, jerky movements, falls, fractures, or underlying musculoskeletal conditions. The result of repetitive activities that strain the muscles, tendons and sprain the ligaments. Insufficient recovery time, rapid pace work, repetitive motion patterns, heavy weight lifting, forceful manual exertions, mechanical pressure concentrations or whole body vibrations can lead to development of other musculoskeletal disorders. The impact of a musculoskeletal condition on an individual's quality of life is substantial, extending beyond mere physical discomfort. Such conditions not only affect personal well-being but also impose a considerable financial strain, manifested through compensation payments and lost wages. Instances of sick leave, absenteeism, and even job abandonment contribute to diminished job efficiency,further exacerbating the socioeconomic repercussions of these disorders.
METHODOLOGY :- A total of 147 participants were selected on the basis of inclusion and exclusion criteria. A consent form was filled by them and the study and questionnaire was explained to them.Self-made Questionnaire was explained to each gym instructors according to language understood by that person as well as google forms were also made available for their convenience.Each gym instructor completed a self administered questionnaire which included information regarding complaints of current shoulder pain. The total data was collected and was statistically analyzed.
CONCLUSION :- The Prevalence of shoulder pain in gym instructors is high (78%). The presence of shoulder pain causes a gym instructors to avoid certain activities due to pain which causes a hindrance in their work related activities.
Physical therapy in a patient with viral -encephalitis hemi-paresis: A Case report
Authors: Shukla Swadeep , Dwivedi Susmita
Published: October 2024

The purpose of the rehabilitation program is to improve motor skills, coordination, sensory system, mobilization and other existing disorders to achieve activity of daily living (ADL). Physical therapy as part of the multidisciplinary approach can provide core stability exercises, muscular facilitation and stimulation of motion of the upper and lower extremities, balance exercises and mobility exercises, as well as strengthening exercises with PNF facilitation and active stimulation techniques and using the patient's body weight as a training burden. Bobath approach and facilitation exercise can reduce spasticity by strengthening the antagonist muscles. MMT right upper extremity 3/5, left upper extremity 4/5, right lower extremity 2/5, and left lower extremity 3/5. Ashworth scale right upper extremity 1/4, right lower extremity 2/4, and left lower extremity 1/4. Clonus is reduced, the patient can stand with maximum support without clonus for 10 minutes. Trunk impairment scale 12/23 and Barthel index 65/100. Anthropometric examination showed differences in the circumference of the lower extremities, namely the right patella circumference 34-32 cm left, right upper leg 39 cm-left 37 cm, and left lower leg 29-24 cm. Mobilize the patient to a laying position with minimal assistance. Mobilization of the patient is being able to sit with minimal assistance, namely stabilization in the pelvis, sitting to standing with moderate support, which is supported at the knee bilaterally, and standing with support at the knee and pelvic for 10 minutes. This case report concludes that although physiotherapy is done late with strengthening exercise and core stability strengthening techniques, lying down strengthening exercise, it can improve motor skills, coordination, which in turn will increase the patient's independence in carrying out functional activities and ADLs.
Correlation Between Level of Physical Activity Using GPAQ and Exercise Capacity Using 6 Min Walk Test in Non-Insulin Dependent Type 2 Diabetes Mellitus
Authors: Pranjali Ramesh Zende  , Namita Parab
Published: October 2024

Background: This study was designed to find the Correlation Between the Level of Physical Activity and Exercise Capacity in Non-Insulin Dependent Type 2 Diabetes Mellitus.
Purpose: To find the Correlation between the Level of Physical Activity and Exercise Capacity in Non-Insulin Dependent Type 2 Diabetes Mellitus.
Materials and Methods: Materials required for this study were Countdown timer (or stopwatch), Two small cones, Chair, Worksheet on a clipboard, Sphygmomanometer. It was a correlational study design. The sampling method used was Convenient type of sampling. Sixty subjects with non-insulin dependent type 2 were included in this study.  The written informed consent was taken. Informed consent document was signed, retained by the principal investigator and a copy was given to the participant. Global Physical Activity Questionnaire and 6 Minutes walk test was used to study the Physical  Activity and Exercise Capacity respectively. All the data obtained was statistically analysed using proper tests.
Results: The results showed positive significant (p value < 0.0001) correlation between the level of physical activity and exercise capacity, Physical activity level correlates statistically with distance walked in percentage.
Conclusion: Our study concluded that Physical activity level correlate statistically with distance walked in type 2 diabetic patients.
Effectiveness of Retraction 30 over Gross Stretch For Relieving Pectoralis Minor Tightness Among College Students
Authors: M S Sangeetha , Subin Chungath
Published: October 2024

Background: The Pectoralis minor muscle originates from different 3 ribs and converges into one attachment point. Pectoralis minor shortening can contribute to many syndromes and impairments, especially at the shoulder. Some of them are impingement of the soft tissues, adhesive capsulitis etc. The prevalence of pectoralis minor tightness is very high in college-going students. The gross stretch is the stretching procedure that increases the length of the pectoralis minor muscle. This shoulder position produces tension in the muscle insertion in a posterior direction in conjunction with the scapular motion that is performed at flexion and elevation in the scapular plane, thereby lengthening the muscle. Retraction 30 is stretching with scapular retraction at 30 degrees of shoulder flexion; the flexion angle at 30 degrees can lengthen the muscle along the muscle fiber direction in the coronal plane. 30 degrees of flexion is considered to be more comfortable than a higher angle of flexion, as well as the angle is closest to the line of force
Objectives of the study: To compare the effectiveness of gross stretch and retraction 30 in relieving pectoralis minor muscle tightness which can be co-operated in further treatment protocols. 
Study Design: Comparative Study
Methodology: Two group pre–test–post–test design was used with purposive sampling. Selected subjects were allocated to two groups. Fourty subjects (20 males and 20 females) who fulfilled inclusion and exclusion criteria were recruited for the study. The independent variables are gross stretch and retraction 30 whereas the dependent variables were PMI (pectoralis minor index), pectoralis minor length test and Cervical Curvature.
Result: This study results imply that retraction 30 is better when compared to gross stretch for correcting pectoralis minor tightness. Hence should be included as an inevitable part of stretching treatment. Practicing clinicians should continue to use evidence-based decisions when treating pectoralis minor tightness.
Flexibar And Non-Flexibar Exercises And Its Effects On Trunk Activation- A Review Of Literature
Authors: Nagaveni Hegde  , Anitha Mariappan
Published: October 2024

Objective: To systematically review the randomised controlled trials to evaluate the effects of flexi-bar and non-flexi-bar exercises, specifically stabilization training, on trunk muscle activity in various postures. Methodology: The study included randomized control trials and clinical trials published between 2007-2018 , focusing on patients with upper trunk muscle weakness aged above 18. Exclusion criteria included a study with overlapping data, a study with associated disorders, or abstract-only papers. The search strategy involved a search of existing literature from databases like PubMed, Google Scholar, Cochrane Library, PEDro, and Research Gate, removing duplicates and identifying relevant articles. The full-text screening was performed, and the remaining relevant articles underwent data extraction. Surface electromyography (EMG) was used to measure the activity of selected trunk muscles, which was then normalized to maximum voluntary isometric contraction. Results: The findings of this study indicate that flexi-bar exercises resulted in higher activation of trunk muscles compared to non-flexi-bar exercises (stabilization training). The unique physical response induced by the vibration created through the swinging motion of the flexi bar triggered reflexive contractions of core muscles, leading to increased muscle activity. This suggests that flexi bar exercises may be beneficial in promoting muscular activation and potentially alleviating low back pain by evening out muscular imbalances.Conclusion: The results of this study support the use of flexi-bar exercises for activating trunk muscles, particularly when compared to non-flexi-bar exercises (stabilization training).
ХАРАКТЕРИСТИКИ КЛИМАТИЧЕСКИХ ИЗМЕНЕНИЙ УРОВНЯ ЧЕРНОГО МОРЯ НА ЮГЕ КРЫМА
Authors: Воронцов Александр Анатольевич
Published: October 2024

В статье рассмотрены изменения уровня моря на юге Крымского полуострова за многолетний период на основе данных измерений ежечасного уровня морян. Приведены статистические характеристики уровенного режима Черного моря в районе Севастополя. Подтвержден положительный тренд в изменении уровня моря.
ПОСТАНОВКА ОБРАЗОВАТЕЛЬНОГО ПРОЦЕССА В РОССИИ В КОНЦЕ ХIХ В
Authors: Александрова Елена Васильевна , Маяков Дмитрий Михайлович
Published: October 2024

Социально-экономические процессы, происходящие в России, призваны решать множество проблем. Приоритетные направления экономического роста России определены в национальных проектах. Одно из ведущих- это модернизация образования.
ЭМПИРИЧЕСКОЕ ИССЛЕДОВАНИЕ ГОТОВНОСТИ ДОШКОЛЬНИКОВ К ОБУЧЕНИЮ В ШКОЛЕ
Authors: Долгова Валентина Ивановна , Кондратьева Ольга Александровна , Федотова Ангелина Сергеевна
Published: October 2024

Организация эмпирического исследования проводилась в три этапа: поисково-подготовительный; опытно-экспериментальный; контрольно-обобщающий. Для определения уровня интеллектуальной готовности к школьному обучению старших дошкольников применялась методика Л.А. Ясюковой.
РАСЧЁТ СИЛ СОПРОТИВЛЕНИЯ КОПАНИЮ НА КОВШЕ ЭКСКАВАТОРА ИЗМЕНЁННОЙ КОНСТРУКЦИИ
Authors: Бурый Григорий Геннадьевич
Published: October 2024

В статье рассматривается ковш экскаватора изменённой конструкции. Приведена схема сил действующих на ковш. Приведены исходные данные и зависимости для расчёта сил сопротивления копанию ковшом изменённой конструкции.