bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of politeness and performance quality of android robots on future interaction decisions: a conversational design perspective
Authors: Saeki Waka , Ueda Yoshiyuki
Published: May 2024

Despite robots being applied in various situations of modern society, some people avoid them or do not feel comfortable interacting with them. Designs that allow robots to interact appropriately with people will make a positive impression on them resulting in a better evaluation of robots, which will solve this problem. To establish such a design, this study conducted two scenario-based experiments focusing on the politeness of the robot’s conversation and behavior, and examined the impressions caused when the robot succeeds or slightly fails at a task. These two experiments revealed that regardless of whether the partner is a robot or a human, politeness not only affected the impression of interaction but also the expectations for better task results on the next occasion. Although the effect of politeness on preference toward robot agents was smaller than those toward human agents when agents failed a task, people were more likely to interact with polite robots and human agents again because they thought that they would not fail the next time. This study revealed that politeness motivates people to interact with robots repeatedly even if they make minor mistakes, suggesting that the politeness design is important for encouraging human-robot interaction.
Enhancement of single-lead dry-electrode ECG through wavelet denoising
Authors: Abdou Abdelrahman , Krishnan Sridhar
Published: May 2024

Neonatal electrocardiogram (ECG) monitoring is an important diagnostic tool for identifying cardiac issues in infants at birth. Long-term remote neonatal dry-electrode ECG monitoring solutions can be an additional step for preventive healthcare measures. In these solutions, power and computationally efficient embedded signal processing techniques for denoising newborn ECGs can assist in increasing neonatal medical wearable time. Wavelet denoising is an appropriate denoising mechanism with low computational complexity that can be implemented on embedded microcontrollers for long-term remote ECG monitoring. Discrete wavelet transform (DWT) denoising for neonatal dry-electrode ECG using different wavelet families is investigated. The wavelet families and mother wavelets used include Daubechies (db1, db2, db3, db4, and db6), symlets (sym5), and coiflets (coif5). Different levels of added white Gaussian noise (AWGN) were added to 19 newborn ECG signals, and denoising was performed to select the appropriate wavelets for neonatal dry-electrode ECG. The selected wavelets then undergo real noise additions of baseline wander and electrode motion to determine their robustness and accuracy. Signal-to-noise ratio (SNR), mean squared error (MSE), and power spectral density (PSD) are used to examine denoising performance. db1, db2, and db3 wavelets are eliminated from analysis where the 30 dB AWGN led to negative SNR improvement for at least one newborn ECG, removing important ECG information. db4 and sym5 are eliminated from selection due to their different waveform morphology compared to the dry-electrode newborn ECG’s QRS complex. db6 and coif5 are selected due to their highest SNR improvement and lowest MSE of 6.26 × 10−6 and 1.65 × 10−7 compared to other wavelets, respectively. Their wavelet shapes are more like a newborn ECG’s QRS morphology, validating their selection. db6 and coif5 showed similar denoising performance, decreasing electrode motion and baseline wander noisy ECG signals by 10 dB and 14 dB, respectively. Further denoising of inherent dry-electrode noise is observed. DWT with coif5 or db6 wavelets is appropriate for denoising newborn dry-electrode ECGs for long-term neonatal dry-electrode ECG monitoring solutions under different noise types. Their similarity to newborn dry-electrode ECGs yields accurate and robust reconstructed denoised newborn dry-electrode ECG signals.
Flowcytometric data of intermediate-large cell gastrointestinal lymphoma presenting a gross mass in 32 cats – “let them glow in the flow”
Authors: Rütgen Barbara C. , Wolfesberger Birgitt , Baumgartner Daniel , Hammer Sabine E. , Groiss Sandra , Hittmair Katharina M. , Gradner Gabriele , Fuchs-Baumgartinger Andrea , Donovan Taryn A. , Schwendenwein Ilse
Published: May 2024

Gastrointestinal lymphoma is the most common form of lymphoma in domestic cats. Aggressive phenotypes are much less common but do bear and unfavorable prognosis. Immunophenotyping by flow cytometry (FCM) is not systematically performed in these patients, because of difficulties in the acquisition of suitable sample material from the gastrointestinal tract. A multimodal diagnostic approach is recommended to improve identification of subtypes targeting patient tailored therapeutic strategies. The aim of this prospective study was to present results of multicolor FCM immunophenotyping in surgically removed gastrointestinal mass and relate them with histopathology using the World Health Organization (WHO) classification and clonality PCR testing. Thirty-two patients were included. Eight cats (25%) had gastric, 23 (72%) had intestinal lymphoma and 1 (3%) had gastric/jejunal lymphoma. Intestinal lymphoma sites were represented by 18 small intestinal, 4 ileocaecal, 1 large intestinal. All gastric lymphomas were diffuse large B-cell lymphoma (DLBCL). Small intestinal lymphomas were 10 enteropathy associated T-cell lymphoma type I (EATL I), 2 enteropathy associated T-cell lymphoma type II (EATL II), 2 peripheral T-cell lymphoma (PTCL), 3 DLBCL and one DLBCL+EATL II. The most common small intestinal FCM T-cell phenotype was CD3+CD21− CD4−CD8−CD18+ CD5−CD79− in 7/10 EATL I and one EATL II. The most frequent FCM B-cell phenotype was CD3−CD21+ CD4−CD8−CD18+ CD5−CD79+ in 13/17 DLBCL and the DLBCL+EATL II. Clonality PCR results were positive in 87.5% (28/32) of all cases. No cross-lineage rearrangement was observed. IHC and FCM results agreed in 87.5% (28/32) of all cases. When all 3 methods were combined, consistent results were seen in 75% (24/32). This is the first demonstration of a multicolor FCM approach set in context to the gold standard histopathology and clonality testing results.
Modulation of cyclophosphamide-induced immunosuppression and intestinal flora in broiler by deep eutectic solvent extracted polysaccharides of Acanthopanax senticosus
Authors: Su Jianqing , Xue Jiaojiao , Wang Xueyan , Zhang Rui , Zhang Xueping , Yang Yaosen , Chu Xiuling
Published: May 2024

Introduction

The aim of this experiment was to investigate the modulation effect of Acanthopanax senticosus polysaccharide (ASPS-PD) extracted with deep eutectic solvent on cyclophosphamide-induced immunosuppression in broilers and its modulation of the gut microbiota of broilers.

Methods

The 108 one-day-old broilers were divided into six groups, including the control group, the Cyclophosphamide (CY) model group, the ASPS-PD control group, the ASPA-PD high and low dose groups and the Astragalus polysaccharide group. Body weight, feed intake, feed conversion ratio, and immune organ index of broilers at 7, 14, and 21 days were determined; IL-2, IFN-γ, and lgG1 levels were determined by enzyme-linked immunosorbent assay (ELISA); Broiler caeca feces were analyzed by amplification and 16S rRNA sequencing.

Results

The results showed that ASPS-PD can restore growth performance, increase immune organ index and improve serum cytokine levels of IL-2 and IFN-γ and immunoglobulin lgG1 levels in CY-treated broilers. The analysis of cecum flora showed that ASPS-PD can promote the proliferation of beneficial bacteria and reduce the number of harmful bacteria, regulating intestinal flora.

Discussion

Therefore, ASPA-PD may be a potential novel immunomodulator to ameliorate CY-induced immunosuppression and intestinal flora dysregulation in broiler.
Genetics, pharmacotherapy, and dietary interventions in childhood obesity
Authors: Son Joe Eun
Published: May 2024

Childhood obesity has emerged as a major global health issue, contributing to the increased prevalence of chronic conditions and adversely affecting the quality of life and future prospects of affected individuals, thereby presenting a substantial societal challenge. This complex condition, influenced by the interplay of genetic predispositions and environmental factors, is characterized by excessive energy intake due to uncontrolled appetite regulation and a Westernized diet. Managing obesity in childhood requires specific considerations compared with adulthood, given the vulnerability of the critical juvenile–adolescent period to toxicity and developmental defects. Consequently, common treatment options for adult obesity may not directly apply to younger populations. Therefore, research on childhood obesity has focused on genetic defects in regulating energy intake, alongside pharmacotherapy and dietary interventions as management approaches, with an emphasis on safety concerns. This review aims to summarize canonical knowledge and recent findings on genetic factors contributing to childhood obesity. Additionally, it assesses the efficacy and safety of existing pharmacotherapies and dietary interventions and suggests future research directions. By providing a comprehensive understanding of the complex dynamics of childhood obesity, this review aims to offer insights into more targeted and effective strategies for addressing this condition, including personalized healthcare solutions.
The Simulation and Parameter Optimization of the Hole-Forming Process of a Duckbilled Hole-Forming Device
Authors: Zhao Binqiang , Ni Xiangdong , Cai Wenqing , Li Kezhi
Published: May 2024

This paper addresses the hole-forming process of a duckbilled hole-forming device. Based on a coupled simulation using the multi-body dynamics software RecurDyn and the discrete element software EDEM, the hole-forming mechanism of a duckbilled hole-forming device and the influence of control parameters on the hole-forming performance of the hole-forming device were studied. In this paper, we analyze the direction and speed of soil particles transported under soil disturbance by a hole-forming device through the simulation and study of the hole-forming mechanism of the hole-forming device. By controlling parameters such as the traction angle, forward speed, and mass of the hole-forming device, the influence of the control parameters on the hole-forming trajectory of the duckbilled hole-forming device was investigated. Orthogonal tests determined the optimal combination of control parameters. The results show that the hole-forming process of the hole-forming device mainly comprises squeezing and shearing the soil to form holes, and the hole-forming performance of the hole-forming device was optimal when the traction angle was 17.3°, the forward speed was 1.11 m/s, and the mass of the hole-forming device was 17.9 kg.
Effect of Dietary Supplementation of Enteric Avian-Origin Lactobacillus casei-Fermented Soybean Meal on the Growth Performance and Intestinal Health of Broiler Chickens
Authors: Zhu Yunlong , Li Jincheng , Liu Jiaxin , Yang Xue , Liu Tingting , Wang Ran , Chen Xiaoting , Yang Huisi , Mo Ziyi , Han Dongyue , Jiang Qingyan , Shu Gang
Published: May 2024

The bacterial strain is key to fermentation, and the intestinal tract in livestock and poultry is a resource bank of good natural strains. The objective of this study was to evaluate the effect of soybean meal fermented using Lactobacillus casei, isolated from healthy broiler intestines with excellent organic acid production, on the intestinal health and growth performance of broilers. A total of 120 Arbor Acre male broiler chickens aged 21 days were fed until 42 days of age. These chickens were randomly divided into four groups with five replicates per group. Each replicate contained six broiler chickens. The specific groups were the control group (basal diet), the low-dose fermented soybean meal (FSBM) additive group (FSBML, basal diet + 0.2 kg/t FSBM), the middle-dose FSBM additive group (FSBMM, basal diet + 2 kg/t FSBM), and the high-dose FSBM additive group (FSBMH, basal diet + 5 kg/t FSBM). The results demonstrated a significant increase in the average daily feed intake (ADFI) and average daily gain (ADG) of the FSBMH group (p < 0.05). The FSBMH group displayed a significantly increased villus height (VH) to crypt depth (CD) ratio (VH/CD) for the duodenum (p < 0.05) and rectum (p < 0.05). The examination of the ileal mucosa showed that the FSBMH group (p < 0.05) had significantly higher levels of glutathione (GSH) activity, as well as higher relative mRNA expression of ZO-1, ZO-2, Occludin, IL-4, IL-6, MCP-1, TNF-α, IFN-α, IFN-β, and IFN-γ. However, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were significantly lower in the FSBMH group (p < 0.05). The FSBMH group also showed higher levels of Nitriliruptoraceae and Ruminococcaceae. In conclusion, the addition of 5 kg/t FSBM to diets had an ameliorative effect on broiler growth performance and intestinal health.
Prediction of Greenhouse Microclimatic Parameters Using Building Transient Simulation and Artificial Neural Networks
Authors: Ećim-Đurić Olivera , Milanović Mihailo , Dimitrijević-Petrović Aleksandra , Mileusnić Zoran , Dragičević Aleksandra , Miodragović Rajko
Published: May 2024

In the realm of agricultural advancement, the relentless quest for agricultural efficiency amidst the vagaries of climate change has positioned greenhouse technology as a linchpin for secure and sustainable food production. The precise management of greenhouse microclimatic conditions i.e., the ability to accurately predict and maintain ideal temperature and relative humidity, is crucial for enhancing plant growth and health, optimizing resource use, and ensuring sustainable agricultural practices. However, maintaining optimal microclimatic conditions is a significant challenge due to the dynamic nature of external environmental influences. This study aims to address the critical need for advanced predictive tools that can enhance the control and management of greenhouse microclimates, thereby supporting sustainable agricultural practices and food security. Our research introduces a novel integration of building transient simulation (TRNSYS) and artificial neural networks (ANNs) to predict temperature and relative humidity inside a greenhouse across the calendar year, based on external atmospheric conditions. The TRNSYS model meticulously simulates the greenhouse’s thermal load, incorporating real-world data to ensure a high level of accuracy in describing the facility’s dynamic behavior. Our ANN model, composed of three layers, underwent optimization to identify the ideal number of neurons, learning rates, and epochs, settling on a model configuration that minimized prediction errors. The evaluation metrics, including root mean square error (RMSE) and mean absolute error (MAE), demonstrated the model’s effectiveness, with an RMSE of 0.3166 °C for temperature and 5.9% for relative humidity, and MAE values of 0.1002° and 3.4%, respectively. These findings underscore the model’s potential as a powerful tool for greenhouse climate control, offering substantial benefits in terms of energy efficiency, resource optimization, and overall sustainability in agriculture. By leveraging detailed dynamic simulations and advanced neural network algorithms, this study contributes significantly to the field of precision agriculture, presenting a novel approach to managing greenhouse environments in the face of changing climatic conditions.
Disentangling the Physiological Responses of Sweet Orange Citrus Trees to Optimize the Design of Deficit Irrigation Strategies
Authors: Rubio-Casal Alfredo Emilio , Durán-Zuazo Víctor Hugo , García-Tejero Iván Francisco
Published: May 2024

Climate change scenarios and water restrictions are key challenges for Mediterranean citriculture, requiring sustainable deficit irrigation (DI) strategies to ensure sustainable yields. Further research on the physiological pathways that regulate crop responses to water stress is necessary. This work describes the physiological limitations induced under drought conditions in young Navelina orange trees, including the crop’s capability to recuperate its physiological status upon rewatering and after water withholding. A trial was conducted in two-year-old trees subjected to three irrigation treatments: a full irrigation treatment (FI) and two different DI strategies. The results show significant decreases in gas exchange rates for stem water potential (ΨStem) values below −1.5 MPa, evidencing diffusive limitations from drought stress. Additionally, there was evidence of increased osmolyte synthesis, a preventative response to oxidative damage. Significantly increased levels of proline (Pro) and malondialdehyde (MDA) were observed with higher levels of water stress (ΨStem < −1.8 MPa), which leads us to assume that this threshold signals the presence of oxidative damage with no capacity for subsequent recovery, probably affecting the final yield.
A Meta-Analysis of the Effects of Dietary Yeast Mannan-Rich Fraction on Broiler Performance and the Implication for Greenhouse Gas Emissions from Chicken Production
Authors: Salami Saheed A. , Taylor-Pickard Jules , Ross Stephen A. , Moran Colm A.
Published: May 2024

Dietary supplementation of yeast-derived mannan-rich fraction (MRF) could improve the gastrointestinal health and production efficiency of broilers, and, consequently, lower the environmental impacts of chicken production. The objective of this meta-analysis was to quantify the retrospective effects of feeding MRF (Actigen®, Alltech Inc., Nicholasville, KY) on the production performance of broilers. The meta-analysis database included 27 studies and consisted of 66 comparisons of MRF-supplemented diets vs. basal (i.e., negative control) and antibiotic-supplemented (i.e., positive control) diets. A total of 34,596 broilers were involved in the comparisons and the average final age of the birds was 35 days. Additionally, the impact of feeding MRF on the carbon footprint (feed and total emission intensities) of chicken production was evaluated using the meta-analysis results of broiler performance (MRF vs. basal diets) to develop a scenario simulation that was analyzed by a life cycle assessment (LCA) model. A database of all trials (MRF vs. basal and antibiotic diets) indicated that feeding MRF increased (p < 0.01) average daily feed intake (ADFI; +3.7%), final body weight (FBW; +3.5%), and average daily gain (ADG; 4.1%) and improved (p < 0.01) feed conversion ratio (FCR; −1.7%) without affecting (p > 0.05) mortality. A subdatabase of MRF vs. basal diets indicated that dietary MRF increased ADFI (+4.5%), FBW (+4.7%), and ADG (+6.3%) and improved FCR (−2.2%) and mortality (−21.1%). For the subdatabase of MRF vs. antibiotic diets, both treatments exhibited equivalent effects (p > 0.05) on broiler performance parameters, suggesting that MRF could be an effective alternative to in-feed antibiotics. Subgroup analysis revealed that different study factors (year of study, breed/strain, production challenges, and MRF feeding duration) influenced the effect of dietary MRF on broiler performance. Simulated life cycle analysis (LCA) indicated that feeding MRF decreased feed and total emission intensities, on average, by −2.4% and −2.1%, respectively. In conclusion, these results demonstrate that dietary MRF is an effective nutritional solution for improving broiler performance, an effective alternative to in-feed antibiotic growth promoters, and reduces the environmental impact of poultry meat production.
The Impact of National Activities on Antibiotic Consumption in Hospitals and Different Departments over a 14-Year Period
Authors: Čižman Milan , Kastrin Tamara , Beović Bojana , Mahnič Aleksander , Bajec Tom ,   Slovenian Surveillance Antibiotic Consumption Group
Published: May 2024

The aim of this study was to assess the use of antibiotics in hospitals and different departments over 14 years (2006–2019) and the impact of various national activities related to this, including national audits of the use of antibiotics for systemic use. The consumption of antibiotics for systemic use (J01) from all Slovenian hospitals (n = 29) and five departments (internal medicine, surgery, ICU (medicine, surgery), paediatrics and gynaecology/obstetrics) was collected. Total hospital consumption was expressed as the number of defined daily doses (DDDs) per 1000 inhabitants per day (DID), the number of DDDs/100 bed days and the number of DDDs/100 admissions. Over 14 years, J01 hospital consumption increased by 13.8%, expressed in DDDs/100 bed days (p = 0.002). In 2019, compared to 2006, the consumption of J01, expressed in DDD/100 bed days, increased from 19.9% to 33.1% in all departments, except intensive care units. J01 consumption expressed in DDD/100 admissions increased by 7.0% to 39.4% in all but paediatric wards (where it decreased by 12.7%). In all years, we observed large variations in the consumption of antibiotics in departments of the same type. The effectiveness of audit interventions aimed at optimizing antibiotic consumption exhibited notable variation across hospitals, with specialized facilities generally demonstrating superior outcomes compared to general hospitals.
Volatile Organic Compounds (VOCs) in Heritage Environments and Their Analysis: A Review
Authors: Paolin Emma , Strlič Matija
Published: May 2024

In the recent years, there has been an increased interest in indoor air quality in heritage environments, specifically in relation to volatile organic compounds (VOCs). These could originate from objects, furnishings, visitors and staff, as well as from olfactory exhibitions. This interest led to a number of studies investigating the “typical” emissions for diverse materials and their impact on the surrounding environment. The analysis of volatile compounds emitted by objects helps in the characterization of the material composition, its conservation history or its degradation processes. This contribution reviews how volatiles are emitted from objects and the commonly used sampling techniques for heritage science applications. A variety of methods are available, from bulk air sample collection to preconcentration using samplers. The commonly studied object types contributing to indoor VOCs are discussed. These include emissions from heritage objects, conservation products, furnishing materials and display cases. Furthermore, olfactory exhibitions are discussed in terms of indoor air quality. Finally, the findings are compared with the current guidelines on indoor volatile concentrations.
Relationship between Ball Impact Point, Type of Stroke and Shot Direction in High-Performance Padel
Authors: Ramón-Llín Jesús , Muñoz Diego , Martín-Miguel Iván , Guzmán José F. , Vučković Goran , Martínez-Gallego Rafael , Sánchez-Alcaraz Bernardino Javier
Published: May 2024

This study aimed to analyze the relationship between ball impact point, type of stroke, and shot direction in high-performance padel. A total of 8363 strokes from nine matches of three national tournaments involving a total of 24 male players were subjected to systematic observation. The variables analyzed were type of stroke, shot direction, and ball impact. A descriptive analysis was conducted for each study variable, with a comparison of the variables performed using Pearson’s Chi-Square test, column proportions determined using a Z test according to Bonferroni (p < 0.05), an association established by corrected standardized residuals, and an effect size calculated using Crammer’s V. The results showed that the most-used stroke types were volleys, serves, groundstrokes, and backwall shots (67.6%). The cross-court direction stood out over down-the-line and inside-out directions. Finally, almost two-thirds of the impact point locations were forward. In addition, the type of stroke determined shot direction and ball impact location. Moreover, the ball’s impact location significantly determined shot direction. In conclusion, these results suggest that the ball impact location and the type of stroke provide information from which padel shot direction can be anticipated. Such knowledge may constitute a very important factor affecting performance and success among padel players.
Development of Technology for the Bioleaching of Uranium in a Solution of Bacterial Immobilization
Authors: Shiderin Bauyrzhan , Bektay Yerkin , Turysbekova Gaukhar , Altynbek Akmurat , Bektayev Maxat
Published: May 2024

This study presents findings regarding the kinetics of ferrous iron oxidation in solution mediated by Acidithiobacillus ferrooxidans bacteria within a continuous-flow bioreactor employing diverse types of immobilizers. The objective is to augment the rate of ferrous iron oxidation in solutions utilizing an immobilizer for Acidithiobacillus ferrooxidans strains. Immobilization represents a promising avenue for enhancing the efficiency of Fe2⁺ oxidation via acidophilic ferrooxidizing bacteria, leading to a several-fold increase in oxidation rate. A comparative analysis was conducted to evaluate the efficacy of different types of immobilizer in facilitating iron oxidation within a continuous-flow bioreactor, including the application of wood chips coated with Fe(OH)3. The results indicate that wood chips coated with iron hydroxide serve as effective type of immobilizer, facilitating the robust attachment of Acidithiobacillus ferrooxidans via electrostatic interactions between negatively charged bacteria and positively charged surfaces. Experimental investigations were conducted using novel immobilization matrices in pilot-scale tests simulating the underground borehole leaching (UBL) of uranium. The bioactivation of leaching solutions enhances the efficiency and environmental compatibility of UBL compared to conventional chemical oxidation methods. The relationships between redox potential and ferric iron content in bioactivated solutions during the UBL of uranium were delineated. The significance of this study lies in its elucidating the pivotal role of Fe2⁺ oxidation in uranium extraction processes, particularly in the context of UBL. By employing bioactivation mediated by Acidithiobacillus ferrooxidans, the study demonstrates not only enhanced uranium extraction efficiency, but also markedly improved environmental sustainability compared to traditional chemical oxidation methods. The findings reveal crucial correlations between redox potential and ferric iron concentration in bioactivated solutions.
The Design of a Parameterization Scheme for 137Cs Based on the WRF-Chem Model and Its Application in Simulating the Fukushima Nuclear Accident
Authors: Long Qun , Zang Zengliang , Ma Xiaoyan , Fang Sheng , Hu Yiwen , Wang Yijie , Zhuang Shuhan , Wang Liang
Published: May 2024

Based on the Weather Research and Forecasting Model Coupled with Chemistry (WRF-Chem) atmospheric chemistry model, a parameterization scheme for the radioactive isotope caesium (137Cs), considering processes such as advection, turbulent diffusion, dry deposition, and wet deposition, was constructed, enabling the spatial distribution simulation of the concentration and deposition of 137Cs. The experimental simulation studies were carried out during the high emission period of the Fukushima nuclear accident (from 11 to 17 March 2011). Two sets of comparison experiments, with or without deposition, were designed, the effects of wind field and precipitation on the spatial transport and ground deposition of 137Cs were analyzed, and the influence of wind field and precipitation on 137Cs vertical transport was analyzed in detail. The results indicate that the model can accurately simulate the meteorological and 137Cs variables. On 15 March, 137Cs dispersed towards the Kanto Plain in Japan under the influence of northeastern winds. In comparison to the experiment without deposition, the concentration of 137Cs in the Fukushima area decreased by approximately 286 Bq·m−3 in the deposition experiment. Under the influence of updrafts in the non-deposition experiment, a 137Cs cloud spread upward to a maximum height of 6 km, whereas in the deposition experiment, the highest dispersion of the 137Cs cloud only reach a height of 4 km. Affected by the wind field, dry deposition is mainly distributed in Fukushima, the Kanto Plain, and their eastern ocean areas, with a maximum dry deposition of 5004.5 kBq·m−2. Wet deposition is mainly influenced by the wind field and precipitation, distributed in the surrounding areas of Fukushima, with a maximum wet deposition of 725.3 kBq·m−2. The single-station test results from the deposition experiment were better than those for the non-deposition experiment: the percentage deviations of the Tokyo, Chiba, Maebashi, and Naraha stations decreased by 61%, 69%, 46%, and 51%, respectively, and the percentage root mean square error decreased by 46%, 25%, 38%, and 48%, respectively.
Construction and Validation of Surface Soil Moisture Inversion Model Based on Remote Sensing and Neural Network
Authors: Lin Rencai , Wei Zheng , Hu Rongxiang , Chen He , Li Yinong , Zhang Baozhong , Wang Fengjing , Hu Dongxia
Published: May 2024

Surface soil moisture (SSM) reflects the dry and wet states of soil. Microwave remote sensing technology can accurately obtain regional SSM in real time and effectively improve the level of agricultural drought monitoring, and it is of great significance for agricultural precision irrigation and smart agriculture construction. Based on Sentinel-1, Sentinel-2, and Landsat-8 images, the effect of vegetation was removed by the water cloud model (WCM), and SSM was retrieved and validated by a radial basis function (RBF) neural network model in bare soil and vegetated areas, respectively. The normalized difference vegetation index (NDVI) calculated by Landsat-8 (NDVI_Landsat-8) had a better effect on removing the influence the of vegetation layer than that of NDVI_Sentinel-2. The RBF network model, established in a bare area (R = 0.796; RMSE = 0.029 cm3/cm3), and the RBF neural network model, established in vegetated areas (R = 0.855; RMSE = 0.024 cm3/cm3), have better simulation effects on SSM than a linear SSM inversion model with single polarization. The introduction of surface parameters to the RBF neural network model can improve the accuracy of the model and realize the high-accuracy inversion of SSM in the study area.
Generalized Bounded Turning Functions Connected with Gregory Coefficients
Authors: Tang Huo , Mujahid Zeeshan , Khan Nazar , Tchier Fairouz , Ghaffar Khan Muhammad
Published: May 2024

In this research article, we introduce new family RG of holomorphic functions, which is related to the generalized bounded turning and generating functions of Gregory coefficients. Leveraging the concept of functions with positive real parts, we acquire the first five coefficients for the functions belonging to this newly defined family, demonstrating their sharpness. Furthermore, we find the third Hankel determinant for functions in the class RG. Moreover, the sharp bounds for logarithmic and inverse coefficients of functions belonging to the under-considered class RG are estimated.
Skew Cyclic and Skew Constacyclic Codes over a Mixed Alphabet
Authors: Gowdhaman Karthick , Mohan Cruz , Durairajan Chinnapillai , Çalkavur Selda , Solé Patrick
Published: May 2024

In this note, we study skew cyclic and skew constacyclic codes over the mixed alphabet R=FqR1R2, where q=pm, p is an odd prime with m odd and R1=Fq+uFq with u2=u, and R2=Fq+uFq+vFq with u2=u,v2=v,uv=vu=0. Such codes consist of the juxtaposition of three codes of the same size over Fq,R1, and R2, respectively. We investigate the generator polynomial for skew cyclic codes over R. Furthermore, we discuss the structural properties of the skew cyclic and skew constacyclic codes over R. We also study their q-ary images under suitable Gray maps.
Influence of Screw Design and Process Parameters on the Product Quality of PEO:LiTFSI Solid Electrolytes Using Solvent-Free Melt Extrusion
Authors: Platen Katharina , Langer Frederieke , Schwenzel Julian
Published: May 2024

All-solid-state battery (ASSB) technology is a new energy system that reduces the safety concerns and improves the battery performance of conventional lithium-ion batteries (LIB). The increasing demand for such new energy systems makes the transition from laboratory scale production of ASSB components to larger scale essential. Therefore, this study investigates the dry extrusion of poly(ethylene oxide):lithium bis (trifluoromethylsulfonyl)imide (PEO:LiTFSI) all-solid-state electrolytes at a ratio of 20:1 (EO:Li). We investigated the influence of different extruder setups on the product quality. For this purpose, different screw designs consisting of conveying, kneading and mixing elements are evaluated. To do so, a completely dry and solvent-free production of PEO:LiTFSI electrolytes using a co-rotating, intermeshing, twin-screw extruder under an inert condition was successfully carried out. The experiments showed that the screw design consisting of kneading elements gives the best results in terms of process stability and homogeneous mixing of the electrolyte components. Electrochemical impedance spectroscopy was used to determine the lithium-ion conductivity. All electrolytes produced had an ionic conductivity (σionic) of (1.1–1.8) × 10−4 S cm−1 at 80 °C.
TRPA1 Covalent Ligand JT010 Modifies T Lymphocyte Activation
Authors: Szabó Katalin , Makkai Géza , Konkoly János , Kormos Viktória , Gaszner Balázs , Berki Tímea , Pintér Erika
Published: May 2024

Transient Receptor Potential Ankyrin 1 (TRPA1) is a non-selective cation channel involved in sensitivity to a plethora of irritating agents and endogenous mediators of oxidative stress. TRPA1 influences neuroinflammation and macrophage and lymphocyte functions, but its role is controversial in immune cells. We reported earlier a detectable, but orders-of-magnitude-lower level of Trpa1 mRNA in monocytes and lymphocytes than in sensory neurons by qRT-PCR analyses of cells from lymphoid organs of mice. Our present goals were to (a) further elucidate the expression of Trpa1 mRNA in immune cells by RNAscope in situ hybridization (ISH) and (b) test the role of TRPA1 in lymphocyte activation. RNAscope ISH confirmed that Trpa1 transcripts were detectable in CD14+ and CD4+ cells from the peritoneal cavity of mice. A selective TRPA1 agonist JT010 elevated Ca2+ levels in these cells only at high concentrations. However, a concentration-dependent inhibitory effect of JT010 was observed on T-cell receptor (TcR)-induced Ca2+ signals in CD4+ T lymphocytes, while JT010 neither modified B cell activation nor ionomycin-stimulated Ca2+ level. Based on our present and past findings, TRPA1 activation negatively modulates T lymphocyte activation, but it does not appear to be a key regulator of TcR-stimulated calcium signaling.
Psychological Characteristics of Students with Passion for Studying
Authors: Larionow Paweł , Gabryś Agnieszka
Published: May 2024

Passion for studying can be considered a significant factor that promotes well-being and mental health in students. This study aimed to examine whether the psychological characteristics of students with a passion for studying differed from those of students without one. To compare these two groups, we used a set of different psychological variables (e.g., academic burnout and vitality), as well as integrated both person-centered (i.e., group comparison research) and variable-centered (i.e., correlational analysis) approaches. During classes, one hundred and fifty-four students from a Polish university completed a comprehensive set of short self-report questionnaires online on different psychological characteristics, including variables related to studying (i.e., passion for studying, academic burnout, and general academic self-efficacy), psychopathology symptoms, perceived stress and somatic complaints, as well as personal resources (vitality, resilience, self-esteem, and optimism). We noted multiple statistically significant differences in psychological characteristics between the two studied groups of students. Thus, harmonious passionate students tended to have more favorable psychological characteristics within variables related to studying, mental or somatic health symptoms, and personal resources compared to the non-passionate students. A harmonious passion for studying seems to have potential health-promoting and health-protecting effects, whereas a lack of passion for studying may lead to less favorable outcomes.
Comparative Analysis of Indoor Air Quality and Thermal Comfort Standards in School Buildings across New Zealand with Other OECD Countries
Authors: Arya Vineet Kumar , Rasheed Eziaku Onyeizu , Samarasinghe Don Amila Sajeevan , Wilkinson Suzanne
Published: May 2024

COVID-19 has improved awareness of the importance of appropriate indoor air quality (IAQ) in indoor spaces, particularly in classrooms where children are expected to learn. Research has shown that poor IAQ and temperature levels affect the cognitive performance of children. In this paper, we critically compare IAQ standards for New Zealand’s Designing Quality Learning Spaces (DQLS Document) against international benchmarks from the Organization for Economic Co-operation and Development (OECD) countries, including ASHRAE 62.1, CIBSE TM57, EN-15251, WHO AQGs, and Building Bulletins 99 and 101. The aim was to ascertain the robustness of New Zealand’s DQLS document, identify areas of superiority, and recommend the required improvement for appropriate IAQ and thermal comfort in classrooms. This comparison review focuses on IAQ parameters: CO2 levels, temperature, ventilation rates, room size, occupant density, and occupancy rates. The findings illuminate a slight lag in New Zealand’s DQLS standards compared to her international counterparts. For instance, while New Zealand’s standards align closely with WHO standards for IAQ concerning temperature and ventilation rates, the recommended CO2 range appears slightly inadequate (800 to 2000 ppm) along with occupancy and classroom size for effectively controlling classroom pollutant growth. This paper emphasises the need to align New Zealand’s IAQ and thermal comfort standards with optimal OECD benchmarks. The identified disparities present opportunities for improving learning spaces in terms of CO2 concentration, size of classroom, and occupant density in schools in New Zealand to meet globally recognised standards, ultimately creating a healthier and more conducive learning environment.
The Creation of Geotechnical Seismic Isolation from Materials with Damping Properties for the Protection of Architectural Monuments
Authors: Bessimbayev Yerik T. , Niyetbay Sayat E. , Awwad Talal , Kuldeyev Erzhan I. , Uderbayev Saken S. , Zhumadilova Zhanar O. , Zhambakina Zauresh M.
Published: May 2024

This paper presents the results of a study on the relevance of seismic isolation systems for protecting architectural monuments from seismic and vibration impacts. This work aims to develop a method for protecting architectural monuments from seismic and vibration effects by installing geotechnical seismic isolation systems made of various geomaterials, such as a silicate soil mixture (SSM), a cement–soil mixture (CSM), a bitumen–soil mixture (BSM), and a rubber–soil mixture (RSM). The novelty of the work lies in the results of studying the wave processes in different models of geomaterials to assess their effectiveness in a seismic isolation system in the form of damping barrier screens to ensure the seismic resistance of architectural monuments. By comparing the amplitude–frequency characteristics of various geomaterials, it was found that the rubber–soil mixture (RSM), the cement–soil mixture (CSM), and the bitumen–soil mixture (BSM) have the most effective damping properties. A proposed method for protecting architectural monuments with geotechnical seismic isolation in the form of vertical screen barriers and technology for their installation ensures the integrity and safety of architectural monuments at all stages of construction and operation.
Clinical Relevance of Resection Margins in Patients with Total Laryngectomy or Laryngopharyngectomy
Authors: Bernard Simone E. , van Lanschot Cornelia G. F. , Sewnaik Aniel , de Ridder Maria A. J. , Hardillo Jose A. , Monserez Dominiek A. , Baatenburg de Jong Robert J. , Koljenović Senada
Published: May 2024

Background: Laryngeal and hypopharyngeal cancer is complex and resection margins are therefore constrained. The aim of this study was to investigate the clinical relevance of resection margins in laryngeal and hypopharyngeal surgery. Methods: A retrospective cohort study was performed for patients treated with a total laryngectomy (TL) or laryngopharyngectomy (TLP) for laryngeal or hypopharyngeal squamous cell carcinoma (LSCC and HSCC, respectively). Within the groups primary LSCC, recurrent LSCC, primary HSCC, and recurrent HSCC the relationship between the status of the resection margin according to the Royal Collage of Pathology and the recurrence and survival rates were investigated. Results: Positive resection margins were found in 54% for primary LSCC, 29% for recurrent LSCC, 62% for primary HSCC, and 44% for recurrent HSCC. For primary and recurrent LSCC, there was a linear association between total recurrence and narrowing margins (p = 0.007 resp. p = 0.008). Multivariate survival analysis for primary and recurrent LSCC showed a significantly worse disease free and disease-specific survival in case of positive margins compared to clear margins. Conclusion: Similar survival rates were recorded for close and clear margins for primary and recurrent LSCC. This may suggest that a margin > 5 mm is not clinically relevant in terms of survival. Therefore, a margin of 1–5 mm should be accepted in certain subsites. Margins < 1 mm are related to significantly worse outcomes and should be avoided.
Synergistic Antitumor Activity of Talazoparib and Temozolomide in Malignant Rhabdoid Tumors
Authors: Mironova Elena , Molinas Sebastian , Pozo Vanessa Del , Bandyopadhyay Abhik M. , Lai Zhao , Kurmashev Dias , Schneider Eric L. , Santi Daniel V. , Chen Yidong , Kurmasheva Raushan T.
Published: May 2024

Malignant rhabdoid tumors (MRTs) are among the most aggressive and treatment-resistant malignancies affecting infants, originating in the kidney, brain, liver, and soft tissues. The 5-year event-free survival rate for these cancers is a mere 20%. In nearly all cases of MRT, the SMARCB1 gene (occasionally SMARCA4)—a pivotal component of the SWI/SNF chromatin remodeling complex—is homozygously deleted, although the precise etiology of these tumors remains unknown. While young patients with localized MRT generally show improved outcomes, especially those who are older and have early-stage disease, the overall prognosis remains poor despite optimal standard treatments. This highlights the urgent need for more effective treatment strategies. We investigated the antitumor activity of a PARP1 inhibitor (talazoparib, TLZ) combined with a DNA alkylating agent (temozolomide, TMZ) in MRT xenograft models. PARP1 is a widely targeted molecule in cancer treatment and, beyond its role in DNA repair, it participates in transcriptional regulation by recruiting chromatin remodeling complexes to modulate DNA accessibility for RNA polymerases. To widen the therapeutic window of the drug combination, we employed PEGylated TLZ (PEG~TLZ), which has been reported to reduce systemic toxicity through slow drug release. Remarkably, our findings indicate that five out of six MRT xenografts exhibited an objective response to PEG~TLZ+TMZ therapy. Significantly, the loss of SMARCB1 was found to confer a protective effect, correlating with higher expression levels of DNA damage and repair proteins in SMARCB1-deficient MRT cells. Additionally, we identified MGMT as a potential biomarker indicative of in vivo MRT response to PEG~TLZ+TMZ therapy. Moreover, our analysis revealed alterations in signaling pathways associated with the observed antitumor efficacy. This study presents a novel and efficacious therapeutic approach for MRT, along with a promising candidate biomarker for predicting tumor response.
Biological Insights and Radiation–Immuno–Oncology Developments in Primary and Secondary Brain Tumors
Authors: Gregucci Fabiana , Beal Kathryn , Knisely Jonathan P. S. , Pagnini Paul , Fiorentino Alba , Bonzano Elisabetta , Vanpouille-Box Claire I. , Cisse Babacar , Pannullo Susan C. , Stieg Philip E. , Formenti Silvia C.
Published: May 2024

Malignant central nervous system (CNS) cancers include a group of heterogeneous dis-eases characterized by a relative resistance to treatments and distinguished as either primary tumors arising in the CNS or secondary tumors that spread from other organs into the brain. Despite therapeutic efforts, they often cause significant mortality and morbidity across all ages. Radiotherapy (RT) remains the main treatment for brain cancers, improving associated symptoms, improving tumor control, and inducing a cure in some. However, the ultimate goal of cancer treatment, to improve a patient’s survival, remains elusive for many CNS cancers, especially primary tumors. Over the years, there have thus been many preclinical studies and clinical trials designed to identify and overcome mechanisms of resistance to improve outcomes after RT and other therapies. For example, immunotherapy delivered concurrent with RT, especially hypo-fractionated stereotactic RT, is synergistic and has revolutionized the clinical management and outcome of some brain tumors, in particular brain metastases (secondary brain tumors). However, its impact on gliomas, the most common primary malignant CNS tumors, remains limited. In this review, we provide an overview of radioresistance mechanisms, the emerging strategies to overcome radioresistance, the role of the tumor microenviroment (TME), and the selection of the most significant results of radiation–immuno–oncological investigations. We also identify novel therapeutic opportunities in primary and secondary brain tumors with the purpose of elucidating current knowledge and stimulating further research to improve tumor control and patients’ survival.
Photonic Devices with Multi-Domain Liquid Crystal Structures
Authors: Kudreyko Aleksey , Chigrinov Vladimir , Neyts Kristiaan , Chausov Denis , Perestoronina Arina
Published: May 2024

Photoalignment by azo dye nanolayers can provide high alignment quality for large-area liquid crystal devices. Application of this technology to active optical elements for signal processing and communications is a hot topic of photonics research. In this article, we review recent demonstrations and performance of liquid crystal photonic devices, discuss the advantages of the proposed technology, and identify challenges and future prospects in the research field of photoaligned multi-domain liquid crystal structures. We believe that the developments discussed here can provide directions for future research and potential opportunities for applications of liquid crystal devices based on multi-domain photoalignment.