bluuebunny/crossref_metadata_2025 huggingface dataset:
‘Fair Quiet, have I found thee here?’: The relationship between garden settings and otium–negotium in sixteenth‐century philosophical dialogues
Authors: Moncrieff Ross
Published: June 2021

Whilst the literary form of the Renaissance philosophical dialogue has increasingly received scholarly attention in recent years, dialogic settings have rarely been the specific, concentrated focus of these efforts. This article will thus pay close attention to the settings, namely garden settings, of Thomas More’s Utopia, Niccolò Machiavelli’s The Art of War and Justus Lipsius’ De Constantia. Building on recent scholarship exploring Renaissance gardens, it suggests that the garden settings of these philosophical dialogues were chosen in order to reflect concerns about the relative merits of the contemplative and active life. Reading the garden as being associated with the contemplative life of otium, it compares the different approaches each of the authors take to their respective garden settings, arguing that the differing portrayals of the garden are informed by an author’s stance on otium and the active life of negotium. It demonstrates that paying attention to the settings of philosophical dialogues can open up new and interesting ways of interrogating a text, and that the utility of the garden setting for authors concerned with the otium‐negotium conflict was that it was both a stable symbol of otium as well as a site of potential ambiguity and contestation.
Semiparametric Model Averaging Prediction for Lifetime Data via Hazards Regression
Authors: Li Jialiang , Yu Tonghui , Lv Jing , Lee Mei-Ling Ting
Published: June 2021

Forecasting survival risks for time-to-event data is an essential task in clinical research. Practitioners often rely on well-structured statistical models to make predictions for patient survival outcomes. The nonparametric proportional hazards model, as an extension of the Cox proportional hazards model, involves an additive nonlinear combination of covariate effects for hazards regression and may be more flexible. When there are a large number of predictors, nonparametric smoothing for different variables cannot be simultaneously optimal using the conventional fitting program. To address such a limitation and still maintain the nonparametric flavour, we present a novel model averaging method to produce model-based prediction for survival outcome and our method automatically offers optimal smoothing for individual nonparametric functional estimation. The proposed semiparametric model averaging prediction (SMAP) method basically approximates the underlying unstructured nonparametric regression function by a weighted sum of low-dimensional nonparametric submodels. The weights are obtained from maximizing the partial likelihood constructed for the aggregated model. Theoretical properties are discussed for the estimated model weights. Simulation studies are conducted to examine the performance of SMAP under various evaluation criteria. Two real examples from genetic research studies motivated our work and are analysed by the proposed SMAP to produce new scientific findings.
Biochemical and cellular markers differentiate recovered, in‐line filtered plasma, and plasma obtained by apheresis methods
Authors: Siekmann Jürgen , Weber Alfred , Bauer Christoph , Turecek Peter L.
Published: June 2021

Background and Objectives

Assessment of plasma quality often focuses on the common safety tests for minimizing the risk of transmitting blood‐borne pathogens. Little attention is paid to the possible quality attributes that ensure a consistent biochemical composition of plasma for fractionation. We therefore investigated the suitability of selected biochemical and haematological attributes that could be used as markers of plasma quality obtained by different separation and pre‐treatment procedures.

Material and Methods

We characterized six plasma types, including source plasma, plasma recovered by classic means and in‐line filtered plasma, by determining the analytical attributes protein content, coagulation factors and markers of coagulation, contact and complement activation. Residual cell content and cell‐specific variables were also measured.

Results

We found relevant differences between the plasma types in complement activation, as indicated by C3a measurements, while thrombin antithrombin complex values and, to a minor extent, activated factor XII concentrations indicated only moderate differences in activation levels of coagulation and contact systems. The most striking differences, however, were detected in residual cell content and concentrations of the platelet‐associated proteins, platelet factor 4 and β‐thromboglobulin. We showed that leucocyte reduction filters disrupt cells. This includes platelets, thereby releasing the platelet‐associated proteins platelet factor 4 and β‐thromboglobulin, and leucocytes as demonstrated by the release of elastase from polymorphonuclear leucocytes. Furthermore, the filtration processing of whole blood can lead to activation of the complement system.

Conclusion

Our results show that biochemical and cellular surrogate markers are valuable discriminators of plasma types.
Vector‐mediated expression of muscle specific kinase restores specific force to muscles in the mdx mouse model of Duchenne muscular dystrophy
Authors: Ban Joanne , Beqaj Besa , Phillips William D.
Published: June 2021

New Findings

What is the central question of this study?

The (dystrophin‐deficient) muscles of mdx mice generate less contractile force per cross‐sectional area (specific force) than those of healthy wild‐type mice: what is the influence of muscle specific kinase (MuSK) upon the properties of the tibialis anterior (TA) muscle in mdx mice?

What is the main finding and its importance?

Injection of adeno‐associated viral vector encoding MuSK into the TA muscle of young mdx mice increased the specific force of the muscle, suggesting the MuSK signalling system has the potential to restore healthy growth to dystrophin‐deficient muscles.

In the mdx mouse model of Duchenne muscular dystrophy, muscle fibres are fragile and prone to injury and degeneration. Compared to wild‐type mice, muscles of mdx mice also develop less specific force (contractile force/cross‐sectional area). We recently reported that injecting adeno‐associated viral vector encoding muscle specific kinase (AAV‐MuSK) into muscles of mdx mice increased utrophin expression and made the muscles more resistant to acute stretch‐induced injury. Here we injected AAV‐MuSK unilaterally into the tibialis anterior muscle of mdx mice at a younger age (4 weeks), and recorded contraction force from the muscles in situ at 12 weeks of age. Compared to contralateral empty‐vector control muscles, muscles injected with AAV‐MuSK produced 28% greater specific force (P = 0.0005). They did not undergo the compensatory hypertrophy that normally occurs in muscles of mdx mice. Injection of AAV encoding rapsyn (a downstream effector of MuSK signalling) caused no such improvement in muscle strength. Muscles injected with AAV‐MuSK displayed a 10% reduction in the number of fibres with centralized nuclei (P = 0.0015). Our results in mdx mice suggest that elevating the expression of MuSK can reduce the incidence of muscle fibre regeneration and improve the strength of dystrophin‐deficient muscles.
Mean and Dynamic Aspects of the Wakes of a Surface-Mounted Cube and Block
Authors: da Silva Barbara L. , Sumner David , Bergstrom Donald J.
Published: June 2021

The flow downstream of surface-mounted finite height square prisms with aspect ratio AR = 1 (cube) and 0.5 (block) was investigated experimentally in a low-speed wind tunnel, to determine the overall structure and dynamic behavior of the wake and the source of the streamwise vorticity. The Reynolds number based on the prisms' width D was Re =7.5×104 and the boundary layer thickness at the location of the prisms was δ/D=0.73. A vortex shedding frequency was found in the wake of the cube, but no periodicity was found in the wake of the block. The mean wake of the cube showed features of prisms below the critical AR, but the wake of the block had a distinct behavior due to the dominant shear flow from the boundary layer. The shear changed the downwash and, consequently, the streamwise vorticity distribution in the wake, in addition to reducing the magnitude of the Reynolds stresses. The phase-average analysis for the cube revealed the alternate shedding of inclined structures related to the streamwise vorticity in the upper part of the wake. These vorticity regions were caused by the alternate bending and entrainment of the side flow, caused by the downwash. The periodic component of the total Reynolds stresses was, however, significantly smaller than the turbulence-related stresses. This study showed that the wake had a transitional behavior for the cube, but became fundamentally different for the block when compared with prisms of higher AR.
Being Pākehā & Researching the Experiences of Māori Women and Weight Loss Surgery: On Ethics & Ethnography
Authors: Joensen Clare
Published: June 2021

This paper proposes that the positionality of Pākehā researchers wishing to learn from Māori, can be reimagined as an atmospheric inter-subjective space within which conversations can happen across difference and between commonalities. I outline my own reckoning as a Pākehā attempting to enter this field as a part of my MA research on Māori women’s experiences of weight loss surgery. I argue that a form of differential distancing, while holding onto an ethic of care, enables a form of academic inquiry that is less stymied by the politics of permission. This paper also proposes that ethical representation can be bolstered by staying close to the logics for living of our participants and conceptualising their narratives through ‘embodied becoming’. I argue that this multi-faceted approach enables ethnography which retrieves nuance and releases participants, to a degree, from discourses that primarily frame individuals as victims of the state.
'Kiwiburn- a ‘Biophilic festival’: Considering mind-body-environment connections to nature in blended festivalscapes'
Authors: Watt Jacqueline Yvonne
Published: June 2021

This article considers biophilic blended festivalscapes through an examination of relevant academic literature and secondary sources, whilst examining ‘Kiwiburn: New Zealand’s regional Burning Man event’ as a case study. A ‘biophilic festival’ can be understood as a festival that uses nature to construct or influence the embodied experiences of participants through their emotional responses, in a way that enhances positive mind-body-environment connections and promotion of biophilia. Examining Kiwiburn through the limitations of a literature review is an attempt to initiate a conversation about biophilia in connection to contemporary festivals. Kiwiburn provides a useful example of how biophilic festivals can be structured to foster sustainability, through mind-body-environment relationships. This article will be considering what principles and design features built into Kiwiburn are intended to drive positive ecological perceptions and practices within its participants; and, whether these biophilic elements have the potential for extension into the everyday lives of festival participants in broader society.
Persistent Submicroscopic Plasmodium falciparum Parasitemia 72 Hours after Treatment with Artemether-Lumefantrine Predicts 42-Day Treatment Failure in Mali and Burkina Faso
Authors: Beshir Khalid B. , Diallo Nouhoum , Somé Fabrice A. , Sombie Salif , Zongo Issaka , Fofana Bakary , Traore Aliou , Dama Souleymane , Bamadio Amadou , Traore Oumar B. , Coulibaly Sam A. , Maurice Ouattara S. , Diarra Amidou , Kaboré Jean Moise , Kodio Aly , Togo Amadou Hamidou , Dara Niawanlou , Coulibaly Moctar , Dao Francois , Nikiema Frederic , Compaore Yves D. , Kabore Naomie T. , Barry Nouhoun , Soulama Issiaka , Sagara Issaka , Sirima Sodiomon B. , Ouédraogo Jean-Bosco , Djimde Abdoulaye , Sutherland Colin J.
Published: June 2021

A recent randomized controlled trial, the WANECAM (West African Network for Clinical Trials of Antimalarial Drugs) trial, conducted at seven centers in West Africa, found that artemether-lumefantrine, artesunate-amodiaquine, pyronaridine-artesunate, and dihydroartemisinin-piperaquine all displayed good efficacy. However, artemether-lumefantrine was associated with a shorter interval between clinical episodes than the other regimens.
Dynamics of Proteins and Macromolecular Machines in Escherichia coli
Authors: Leroux Maxime , Soubry Nicolas , Reyes-Lamothe Rodrigo
Published: June 2021

Proteins are major contributors to the composition and the functions in the cell. They often assemble into larger structures, macromolecular machines, to carry out intricate essential functions.
Vibrio cholerae Infection Induces Strain-Specific Modulation of the Zebrafish Intestinal Microbiome
Authors: Breen Paul , Winters Andrew D. , Theis Kevin R. , Withey Jeffrey H.
Published: June 2021

Zebrafish (
Danio rerio
) is an attractive model organism to use for an array of scientific studies, including host-microbe interactions. Zebrafish contain a core (i.e., consistently detected) intestinal microbiome consisting primarily of
Proteobacteria
.
A Structural Model for the Ligand Binding of Pneumococcal Serotype 3 Capsular Polysaccharide-Specific Protective Antibodies
Authors: Ozdilek Ahmet , Huang Jiachen , Babb Rachelle , Paschall Amy V. , Middleton Dustin R. , Duke Jeremy A. , Pirofski Liise-anne , Mousa Jarrod J. , Avci Fikri Y.
Published: June 2021

Infectious diseases caused by pathogenic bacteria are a major threat to human health. Capsular polysaccharides (CPSs) of many pathogenic bacteria have been used as the main components of glycoconjugate vaccines against bacterial diseases in clinical practice worldwide, with various degrees of success.
Draft Genome Sequence of Environmental Isolate Acinetobacter nosocomialis U20-HoPe-S34-3 from Germany
Authors: Wilharm Gottfried
Published: June 2021

The draft genome sequence of
Acinetobacter nosocomialis
U20-HoPe-S34-3, isolated from soil sampled from the banks of the river Holtemme in Germany, is provided. The strain has an average nucleotide identity of 98.3% to the type strain of the species.
Draft Genome Sequence of Neobacillus cucumis Strain T4S4, a Stevioside and Rebaudioside A Hydrolytic Strain Isolated from Tropical Forest Soil
Authors: Asawasriworanan T. , Harnvoravongchai P. , Somana J. , Chankhamhaengdecha S. , Ounjai P.
Published: June 2021

Neobacillus cucumis
T4S4 was isolated from montane rain forest soil in Thailand. This strain possesses the ability to hydrolyze stevioside and rebaudioside A, the two major steviol glycosides found in the stevia plant. The draft genome sequence of T4S4 yielded a circular chromosome of 5,978,437 bases with 38.9% GC content.
Genome-Scale Metabolic Model of
Caldicellulosiruptor bescii
Reveals Optimal Metabolic Engineering Strategies for Bio-based Chemical Production
Authors: Zhang Ke , Zhao Weishu , Rodionov Dmitry A. , Rubinstein Gabriel M. , Nguyen Diep N. , Tanwee Tania N. N. , Crosby James , Bing Ryan G. , Kelly Robert M. , Adams Michael W. W. , Zhang Ying
Published: June 2021

The extremely thermophilic cellulolytic bacterium,
Caldicellulosiruptor bescii
, degrades plant biomass at high temperatures without any pretreatments and can serve as a strategic platform for industrial applications. The metabolic engineering of
C. bescii
, however, faces potential bottlenecks in bio-based chemical productions.
Supplemental Material: Earth’s new tectonic regime at the dawn of the Paleoproterozoic: Hf isotope evidence for efficient crustal growth and reworking in the São Francisco craton, Brazil
Authors: Bruno Henrique , al. et
Published: June 2021

Methodology and sample descriptions.
Supplemental Material: A new kind of invisible gold in pyrite hosted in deformation-related dislocations
Authors: Fougerouse Denis , al. et
Published: June 2021

Supplemental geological context, analytical methods, and supporting data.
Supplemental Material: Igneous rock area and age in continental crust
Authors: Peters Shanan , al. et
Published: June 2021

Supplemental Figures S1 and S2, and Table S1 (data used in this analysis).
Supplemental Material: Explosive caldera-forming eruptions and debris-filled vents: Gargle dynamics
Authors: Valentine Greg , Cole Meredith
Published: June 2021

Item S1 (global caldera data), and Item S2 (modeling approach).
Molecular Beacon DNA Probes with Fluorescein Bifluorophore
Authors: Brylev V. A. , Lysenko I. L. , Kokin E. A. , Martynenko-Makaev Y. V. , Ryazantsev D. Y. , Shmanai V. V. , Korshun V. A.
Published: June 2021

Abstract—

An azido-derivative of a fluorescein bifluorophore was obtained and used for the synthesis of “molecular beacon”-type oligonucleotide fluorogenic probes for RT-PCR. Eight probe variants were synthesized based on an optimized sequence: with one or two quencher residues at the 3'-end, with a single or bifluorophore fluorescein label attached to 5'-end using modifying phosphoramidites (short linker) or “click reaction” (long linker). Comparison of probes in RT-PCR showed that probes with a doubled quencher (single fluorescein on a short linker) and doubled dye on a short linker (single dye) are somewhat superior in sensitivity to a standard probe (single quencher, single dye on a short linker) by the value of ΔCt = 1–2.
Reducing emergency department visits in patients with deep vein thrombosis: introducing a standardised outpatient treatment pathway
Authors: Wan Tony , Rahmani Anna , Hanakova Michaela , Wong Hing Yi , Caragata Glenyth , Ross Emily S , Akinyemi Oluwadamilola
Published: June 2021

Deep vein thrombosis (DVT) is an acute medical condition that requires urgent diagnosis and treatment to prevent significant morbidity and mortality. Patients with DVT frequently present to the emergency department (ED) because the necessary diagnostic investigations and medical treatment for successful outpatient management are not readily accessible in the outpatient clinics. A collaborative quality improvement project was undertaken to implement and evaluate a standardised outpatient treatment pathway designed to direct patients with a newly diagnosed DVT from the ultrasound department to the thrombosis clinic, where guideline-based management for DVT can be accomplished without ED visits. During the baseline period (1 February 2017 to 31 January 2019), the number of ED visits for DVT was 383 with an average of 16 visits per month. During the intervention period (1 February 2019 to 31 January 2020), the number of ED visits for DVT was 106 with an average of 8.8 visits per month. This represents almost a 50% reduction in the average ED visits during the intervention period. A standardised outpatient treatment pathway can significantly reduce the number of ED visits in patients with DVT, potentially improving patient care and reducing ED overcrowding.
Promoting social emotional development during the paediatric well-child visit: a demonstration project
Authors: Johnson Meghan L , Butts-Dion Sue , Menon Meera , Edwards Kelly , Berns Scott D
Published: June 2021

Supporting social emotional development, beginning at birth, can improve lifelong health. The American Academy of Paediatrics recommends 12 well-child visits between birth and age 3 years. Each well-child visit provides a unique opportunity to interact with and support families to promote social emotional development of children. Eighteen US paediatric practices joined a learning community to use improvement science to test and implement evidence-informed strategies that nurture parent–child relationships and promote the social emotional development of young children.

Quality improvement methods were used to integrate 11 strategies into well-child visits between birth and age 3 years and measure the improvements with a set of outcome, process and balancing measures. Participation among the 18 paediatric practices was high with 72% of teams attending monthly webinars and 97% of teams attending the three learning sessions. Over 12 months, the percentage of children receiving age-appropriate social emotional development screens at participating practices’ well-child visits increased from a baseline median of 83% to 93%.

Current paediatric practice in the USA focuses primarily on cognitive and physical development, and paediatric providers are less familiar with established practices to screen for social emotional development and promote the caregiver–child relationship. This project suggests that improvement methods show promise in increasing the number of children who receive age-appropriate social emotional development screens or assessments at well-child visits.
Patterns of rare moss diversity and distribution in Alberta
Authors: Belland René J. , Caners Richard T.
Published: June 2021

Rare moss diversity and distribution patterns are described for the province of Alberta. Multivariate analyses were used to elucidate the distribution patterns of the rare mosses in relation to environmental factors, in comparison with those of the common mosses. Hierarchical clustering of species occurrence among Alberta ecoregions resulted in 11 species groups having similar distributions and four ecoregion groups with similar species composition. Rare and common mosses show comparable distributions at the geographic scale of ecoregions; the analyses did not provide support that rare mosses respond to environment factors differently than common mosses. The rare mosses are more narrowly distributed among the species and ecoregion groups than are common species. The most important environmental variables determining species distributions are mean annual temperature and growing degree days. Other important factors determining moss distribution are mean elevation, annual rainfall, and mountain landscape. Diversity patterns are shown to vary widely among the ecoregions and to differ between rare and common species. Rare species are especially diverse in the Rocky Mountains, which support 81% of the province’s known rare moss flora and reflect a complex of diverse landscapes for moss colonization. Only 40% of known rare species in Alberta are found in nonmountainous regions.
FEM SIMULATION ASSESSMENT OF MACHINING TITANIUM GRADE 2 USING TEXTURED TOOL
Authors: ROY RIMA SINGHA , MAITY KALIPADA
Published: June 2021

This work focuses on the 3D numerical investigation of machinability criteria using textured tools for the dry machining of titanium grade 2. For the development of the 3D finite element model, DEFORM-3D (version 10.1) software was used. Dimple patterns were created nearer to the cutting edge region on the rake face of carbide inserts so as to predict their effect and investigate the machinability criteria. Comparison of dimple-textured tool was being made with a conventional tool based on the cutting forces ([Formula: see text], [Formula: see text] and [Formula: see text], cutting temperature, tool wear, effective stress and effective strain. The numerical study revealed that the dimple-patterned tool improved the machinability of titanium grade 2. The cutting forces (tangential cutting force, feed force and radial force) reduced while machining with a dimple-patterned tool as compared to the conventional nontextured tool. There was an enhancement of tool life and a decrease in effective stress and effective strain while dry turning grade-2 titanium alloy using the textured tool.
FACTOR COPULA MODEL FOR PORTFOLIO CREDIT RISK
Authors: KIM SUNG IK , KIM YOUNG SHIN
Published: June 2021

A critical aspect in the valuation and risk management of multi-name credit derivatives is the modeling of the dependence among sources of credit risk. The dependence modeling poses difficulties in the pricing of a multi-name credit derivatives, in the estimation of the value-at-risk of a portfolio, or in the pricing of some other basket credit derivative as the description not only on the default arrival in an individual reference entity but on the default dependence among entities in the portfolio should be considered. Although the elliptical models have been widely used due to their mathematical tractability, the dependence modeling using the multi-dimensional Lévy process has shown growing interest among researchers despite its complexity. In this paper, we introduce one factor copula model for portfolio credit risk based on Normal Tempered Stable (NTS) distribution and calibrate the model through 5-year synthetic Collateralized Debt Obligation (CDO) tranche spreads under a large homogeneous portfolio approximation. The calibration results show that the one factor copula model based on NTS distribution is more flexible and provides a dependence structure fitting market CDO tranche spreads. As one of the major applications of the dependence modeling in credit risk, this model shares the advantage of the Gaussian one factor model, and all extensions and implementation methods used for it can be utilized.
COMPUTER HYBRID SYSTEM OF HEMORRHAGE (HES) DETECTION USED FOR AIDED DIAGNOSIS OF DIABETIC RETINOPATHY
Authors: FEROUI A. , MESSADI M. , LAZOUNI A. , BESSAID A.
Published: June 2021

Diabetes cause’s metabolic and physiological abnormalities in the retina and the changes suggest a role for inflammation in the development of diabetic retinopathy. Abnormal blood vessels can form in the back of the eye of a person with diabetes. These new blood vessels are weaker and prone to breaking and causing hemorrhage (HEs). Diabetic retinopathy (DR) accounts for 31.5–54% of all cases of vitreous hemorrhage in adults in the world. Therefore, detection of HEs is still a challenging factor task for computer-aided diagnostics of DR. Many researchers have developed advanced algorithms of hemorrhages detection using fundus images. In this paper, a robust and computationally efficient approach for HEs with different shape and size detection and classification is presented. First, brightness correction and contrast enhancement are applied to fundus images. Second, candidate hemorrhages are extracted by using an unsupervised classification algorithm. Third, an approach based on mathematical morphology is carried out for vascular network and macula segmentation. Finally, a total of 13 HEs features are considered in this study and selected for classification. The proposed method is evaluated on 419 fundus images of DIARETDB0, DIARETDB1 and MESSIDOR databases. Experimental results show that overall average sensitivity, specificity, predictive value and accuracy for hemorrhage in lesion level are 98.90%, 99.66%, 97.63% and 99.56%, respectively. The results show that the proposed method outperforms other state-of-the-art methods in detection of hemorrhages. These results indicate that this new method may improve the performance of diagnosis of DR system.
Music Feature Classification Based on Recurrent Neural Networks with Channel Attention Mechanism
Authors: Gan Jie
Published: June 2021

With the advancement of multimedia and digital technologies, music resources are rapidly increasing over the Internet, which changed listeners’ habits from hard drives to online music platforms. It has allowed the researchers to use classification technologies for efficient storage, organization, retrieval, and recommendation of music resources. The traditional music classification methods use many artificially designed acoustic features, which require knowledge in the music field. The features of different classification tasks are often not universal. This paper provides a solution to this problem by proposing a novel recurrent neural network method with a channel attention mechanism for music feature classification. The music classification method based on a convolutional neural network ignores the timing characteristics of the audio itself. Therefore, this paper combines convolution structure with the bidirectional recurrent neural network and uses the attention mechanism to assign different attention weights to the output of the recurrent neural network at different times; the weights are assigned for getting a better representation of the overall characteristics of the music. The classification accuracy of the model on the GTZAN data set has increased to 93.1%. The AUC on the multilabel labeling data set MagnaTagATune has reached 92.3%, surpassing other comparison methods. The labeling of different music labels has been analyzed. This method has good labeling ability for most of the labels of music genres. Also, it has good performance on some labels of musical instruments, singing, and emotion categories.
Case Report: Fibroglial Retinal Tissue in Contractile Morning Glory Disc Anomaly
Authors: Ramirez-Estudillo Abel , Torres-Navarro Karla , Rojas-Juárez Sergio , Ramirez-Galicia Ximena , Palafox-Cornejo Berenice , Galicia-Castillo Adriana
Published: June 2021

The purpose of the present case is to describe a patient with tractional retinal detachment (RD) associated with contractile morning glory: a 17-year-old female, with a history of failed surgery for RD when she was 2 years old in her right eye (OD), nystagmus, and a limited visual acuity in the left eye (OS). The slit lamp examination showed phthisis bulbi in OD and the anterior segment was unremarkable in OS. Dilated fundus examination revealed a tractional RD in the posterior pole and peripapillary and preretinal fibrosis without evidence of intravitreal dispersion of retinal pigment epithelial cells. After surgery treatment, the RD resolved and the posterior segment showed a staphylomatous excavation around the optic disc anomaly with irregular contractions that folded the macular area. This were unrelated to light, breathing, or eye movements. Although morning glory disc anomaly is associated with RD, the early diagnosis can reverse structural changes. In this case, the rare association with contractile movements was found posterior to the pars plana vitrectomy after all the fibroglial epiretinal tissue was removed.
Monocular Diplopia: An Optical Correction Modality
Authors: Alemu Haile W. , Kumar Preetam
Published: June 2021

Post-surgical or traumatic corectopia is among the rare causes of monocular diplopia. A 26-years-old student presented to the Institute with a complaint of monocular double vision in the left eye. He had a penetrating ocular injury in the left eye and subsequently, undergone for multiple ocular surgeries. Following the final intraocular lens implantation, he experienced a monocular double vision in his left eye. Upon contact lens clinic presentation, visual acuities were 20/20 in the right and 20/320 in the left eye (improved to 20/25 with pinhole). Slit-lamp examination on the left eye revealed scarring in the superior nasal quadrant of the cornea, irregular mid-dilated pupil with exposed aphakic and pseudophakic portions. A range of different optical management options were implemented to eliminate monocular diplopia and to correct refractive error. Finally, a combination of prosthetic soft contact lens and spectacle correction was able to remove diplopia and provide binocular single vision.
Can Discord Domain-Containing Receptor 2 Mutation Act as a Disease Modifier for PRKAR1A Associated Melanotic Schwannoma?
Authors: Roman Hernandez Erica M. , Valasareddi Sri Laxmi , Adkison Jarrod , Awan Henna , Basarakodu Krishnamohan R. , Velayati Arash
Published: June 2021

Melanotic Schwannomas are rare neural sheath tumors with distinctive findings of both Schwann cells and melanocytic cells. Recognition of this entity has prompted the importance of distinction from similar tumor types such as melanomas. Early diagnosis facilitates removal of the mass with less risk of local invasion and metastasis. Although previously known as mostly benign lesions, malignant conversion and recurrence are recognized. This paper presents a patient with melanotic schwannoma, describes the distinctive features that will separate it from melanoma, and addresses the possibility of further guided therapy through next-generation sequencing.
Video-Endoscopic Mobilization of the Gracilis Muscle for Rectourinary Fistula Repair
Authors: Britto Cesar , Pfalzgraf Daniel , Lima Ronnie , Medeiros Paulo , Rebouças Rafael , Passerotti Carlo
Published: June 2021

Introduction: Transposition of the gracilis has been used in a large number of reconstructive procedures. Its advantage is its proximity to these defects and a good blood supply. Traditionally, the gracilis mobilization is performed by open surgery with one or more incisions. We describe our initial experience with the video-endoscopic mobilization of gracilis. Method: We described a retrospective review of all patients who underwent gracilis muscle mobilization for treatment of rectourethral fistula, performed by video-endoscopy, between March 2013 and September 2017, for treatment of rectourethral fistula. Also, our surgical technique is described in detail. Results: Three patients, with a mean age of 66.6 years, underwent the procedures. The mean time for mobilization of the gracilis was 107 min (range 60–145). There was no case of donor area infection, no change in the sensitivity of the medial aspect of the thigh or chronic pain. Conversion to open surgery was not necessary in any case. The hospital discharge occurred in average after 4 days. The bladder catheter was removed after 4 weeks after cystography was performed without evidence of leakage. One patient had a recurrence of the fistula. Discussion: The gracilis is an excellent choice of tissue to be interposed in reconstructive procedures of the perineal region, especially in the treatment of rectourinary fistulas. However, endoscopic harvest of the gracilis muscle has not yet found its way into everyday practice. The results in the treatment of rectourinary fistulas are excellent, with a success rate of 87.7%. Our rate of 67% is below, probably due to the small number of cases. In open surgery, complications are uncommon; however, approximately half of the patients expressed concern about the painful scar, which can be reduced by minimally invasive access. Conclusion: Video-endoscopic mobilization of gracilis muscle for the treatment of rectourethral fistula is feasible and safe. Studies comparing this technique with the conventional mobilization are required.
ctDNA Clearance and Radiographic Resolution of Disease in Response to Dual Checkpoint Inhibition in Metastatic Microsatellite Stable Colorectal Cancer with a High Tumor Mutation Burden
Authors: Schneider Charles J. , Krainock Michael , Malashevich Allyson Koyen , Malhotra Meenakshi , Olshan Perry , Billings Paul R. , Aleshin Alexey
Published: June 2021

Immunotherapy (IO) has increasingly been demonstrated to provide therapeutic benefit to patients with metastatic colorectal cancer (mCRC). However, only a subset of mCRC tumors respond to IO. Monitoring response with tumor biomarkers like carcinoembryonic antigen (CEA) has been challenging in patients with microsatellite stable (MSS) mCRC due to low expression of CEA (CEA/lo). Noninvasive blood-based biomarkers such as circulating tumor DNA (ctDNA) can inform early treatment response and augment radiographic monitoring. We describe a case study of a patient with chemotherapy-refractory CEA/lo MSS mCRC, with metastatic disease present in a cardiophrenic lymph node. The patient was given 2 cycles of combination IO (ipilimumab/nivolumab). Response was monitored by ctDNA using a multiplex PCR next-generation sequencing assay, CEA, and CT scan. After IO administration, ctDNA levels rapidly declined, becoming undetectable. This was concurrent with radiographic resolution of the lymph node metastasis. Serial monitoring of CEA during this same period was uninformative, with no significant changes observed. Significant decline in ctDNA identified metastatic response to IO in a patient with CEA/lo, MSS mCRC and was concurrently validated by CT scan. This case study provides evidence that ctDNA can be used as a prospective surrogate for radiographic tumor response.
ЗАСТОСУВАННЯ ІНТЕРНЕТ-ТЕХНОЛОГІЙ У НАВЧАЛЬНОМУ ПРОЦЕСІ ПРИ ПІДГОТОВЦІ МЕДИЧНОЇ СЕСТРИ
Authors: Ryzhkovskyi V. O.
Published: June 2021

У статті проаналізовано значення і можливості глобальної мережі Інтернет при підготовці висококваліфікованої медсестри, а також фактори, що сприяють застосуванню даного виду технології.
ЛІСТЕРІОЗ
Authors: Fundytus P. B. , Orlenko A. L. , Buchko P. I.
Published: June 2021

У статті викладено основні клінічні прояви лістеріозу, їх поліморфізм, а також  заходи які направленні на лікування та профілактику хвороби.
УЧАСТЬ МЕДИЧНОЇ СЕСТРИ В РАННІЙ ДІАГНОСТИЦІ ЗЛОЯКІСНИХ НОВОУТВОРЕНЬ ТА ДОГЛЯД ЗА ОНКОХВОРИМИ В ЛІКАРНІ І ВДОМА
Authors: Orlenko A. L. , Buchko P. I. , Fundytus P. B.
Published: June 2021

У статті висвітлено роль медичної сестри у ранній діагностиці злоякісних новоутворень, її дії та основні принципи догляду за пацієнтами з онкологічними захворюваннями в закладах охорони здоров’я та в домашніх умовах.
Catarina de Médici(1519-1589): Imagens de gênero e poder
Authors: Scoz Eduardo Gern
Published: June 2021

Este artigo é produto de pesquisa individual de conclusão de curso de graduação em História, intitulada Catarina de Médici (1519-1589): imagens de gênero e poder, orientada pela Professora Doutora Ana Paula Vosne Martins (UFPR). O projeto objetiva compreender as articulações entre gênero e poder na França Renascentista a partir da trajetória biográfica e política da rainha-mãe Catarina de Médici, esposa de Henrique II e regente de seu filho, o rei Carlos IX (1560-1574). Pretende-se analisar as particularidades do exercício do poder e da influência exercida por Catarina no contexto político das guerras de religião na França, primeiro como esposa, mas especialmente como viúva e mãe de três monarcas. Defendemos a hipótese de que Catarina soube manejar o papel tradicional esperado de uma rainha mãe em favor de seus filhos, da dinastia dos Valois-Angoulême e da monarquia francesa, exercendo o que chamamos de maternidade política. Para desenvolver esta problemática recorremos às fontes literárias, imagéticas e epistolares.
"Em legítima defesa da honra": a luta contra a naturalização da violência contra as mulheres
Authors: Silva Kathiusy Gomes
Published: June 2021

O objetivo deste artigo é historicizar a conquista de espaços de defesa da mulher em situação de violência, enfatizando a Delegacia da Mulher (1985) e a Lei 11.340 /06, popularmente conhecida como "Lei Maria da Penha". No artigo, procuramos relatar as leituras com muitas reportagens presentes em uma revista brasileira chamada "Veja", para compreender como essa mídia construiu um discurso em relação à violência cometida contra as mulheres e a luta por direitos e punições aos agressores.
First record of Cercyon (s. str.) inquinatus Wollaston, 1854 from Turkey with notes about this problematic species (Coleoptera: Hydrophilidae: Sphaeridiinae: Megasternini)
Authors: QUENEY PIERRE , ÇIÇEK AHMET , ŞEN ISMAIL
Published: June 2021

Cercyon (s. str.) inquinatus Wollaston, 1854 is recorded for the first time from Turkey. It was found in the darkest part of a vast cave occupied by an underground river and pools. The specimens were collected, in or near water, without being sure that they are aquatic and subterranean. Bright and black or blackish body, pronotum with a slight partial and median groove, rather convex interstries, male genitalia are quite characteristic. The habitat and sampling methods are described. The difficulty of identifying the insect with existing keys is exposed and analyzed. Photos of Turkish specimen and a list of the associated fauna are provided.
Diaparsis phobos sp. nov. and D. deimos sp. nov., two amazing new species of Tersilochinae (Hymenoptera: Ichneumonidae) from Madagascar
Authors: KHALAIM ANDREY I.
Published: June 2021

Two species of the genus Diaparsis Förster, D. phobos sp. nov. and D. deimos sp. nov., are described from Madagascar. The genus Diaparsis, as well as the subfamily Tersilochinae, is recorded from Madagascar for the first time. Both new species possess unuque morphological features previously unknown in the subfamily Tersilochinae: D. deimos sp. nov. has a remarkable slightly decurved ovipositor, and D. phobos sp. nov. possesses deep impressions on outer sides of ocelli.
Design, synthesis and biological evaluation as immunosuppressant of amino alcohol derivatives containing thioether
Authors: Li Yanjie , Li Yongqiang , Yang Liu , Liu Zhi , Zhang Ruimeng , Zhen Xiaowen , Lu Haibin , Wang Ensi
Published: June 2021

To develop a safer immunosuppressant for organ transplantation and autoimmune disease treatment, in this study, several of novel amino alcohol derivatives containing thioether moiety were synthesized with 7-bromo-tetralin-2-one as starting material, and Suzuki coupling reaction and Bucherer-Bergs reaction as key steps. Their activity as sphingosine 1-phosphate receptor type 1 (S1P1) agonists were evaluated by [γ-35S] GTP binding assay. Among the thioether substituted compounds, compound10showed good activity as S1P1agonist at low micromolar concentration (EC50 = 0.698 μmol/L). The result suggested that it has potential activity against autoimmune diseases and immunosuppressant of organ transplantations.
Magnesium alloy stents: A friend or foe of coronary in-stent restenosis?
Authors: Chen Yigang , Shen Ruizhi , Qu Huiheng , Bian Linjie , Fan Xinqi , Xia Jiazeng , Xu Zekuan
Published: June 2021

Coronary artery disease (CAD) is regarded as the principal cause of cardiovascular diseases and one of the leading causes of mortality. In order to alleviate the risk of CAD, percutaneous coronary intervention (PCI) and stent implantation have recently been applied. In particular, Mg
alloy (Mg-alloy) stents (MAS) have been used as clinical routine for the treatment of CAD. However, emerging evidence suggests that this treatment strategy is substantially associated with coronary in-stent restenosis (ISR), which remains the main cause of unintentional and repeat drug-eluting
stent (DES) interventions in the United States. In this regard, understanding of MAS as friend or foe of ISR treatment is needed to establish the exact mechanism underlying this condition. This mini review therefore aimed to provide an integrated view on the existing findings of the relationship
between MAS and ISR. The understanding of MAS as either a friend or foe is crucial for the management of ISR, which is reported to be very challenging amidst lack of effective therapeutic options.
Heparanase-induced proliferation and inhibition of apoptosis are associated with the phosphatase and tensin homologue deleted on chromosome 10/focal adhesion kinase signaling pathway in multiple myeloma
Authors: Yang Yuxing , Huang Beihui , Liu Junru , Chen Meilan , Kuang Lifen , Xu Xiaoxuan , Li Juan
Published: June 2021

Heparanase (HPSE) has an important effect on the proliferation, invasion, metastasis, and drug resistance of tumor cells. HPSE can promote proliferation and inhibit apoptosis of various solid tumor cells. Previous studies regarding the function of HPSE in multiple myeloma (MM) have
primarily focused on tumor invasion and metastasis, whereas few studies have examined the proliferation and apoptosis of MM and the mechanisms associated with HPSE. This study recruited patients with MM and isolated MM cells (RPMI8226, LP-1) were isolated to measure the expression levels of
HPSE, phosphatase and tensin homologue deleted on chromosome 10 (PTEN), and focal adhesion kinase (FAK) proteins to elucidate their roles in tumor formation. Compared with non-tumor patients, the mRNA and protein expression levels of HPSE and FAK in MM patients increased, whereas the levels
of PTEN mRNA and protein decreased. Thus, the increase of HPSE coincided with an increase of FAK and a decrease of PTEN. MM cells exhibiting high HPSE expression exhibited increased proliferation and decreased AS2O3-induced apoptosis. These results indicate that changes
in HPSE expression affect the proliferation and apoptosis of MM cells and this mechanism may be associated with the PTEN/FAK signaling pathway. Gene transfection needs proper vector, and proper gene transport system can improve transfection efficiency. In this paper, magnetic nanoparticles
were transfected with overexpressed HPSE, and to detect the transfection efficiency and the proliferation ability of MM cells in the control group. The results showed that the cells transfected with magnetic nanoparticles had higher transfection efficiency and higher gene expression level.
The results of this experiment provide a new way to explore new cancer therapy genes.
The Visual Culture of Revelation: Visions and the Images that Reveal Them
Authors: Morgan David
Published: June 2021

It is often thought that since remote, rare, and ephemeral events such as apparitions are not available to the direct observation of scholars, the question of their nature as events must be set aside in scholarly inquiry. This results in a focus on meaning that can ignore the qualities of the event as reported and as apprehended by devotional imagery that emerges over time to provide access to the event and its relevance for devotional practice. It also encourages concepts of revelation that are not able to consider the event as a visual form of experience and regard revelation itself as something that must be either true or false. This essay proceeds otherwise, arguing that revelation is not a single, closed event, but an ongoing visual process in which sketchy schemata interact with fixed imagery to interpret the event in an ongoing history of iconography and visual interpretation. The essay focuses on the visuality of devotion to Our Lady of Fátima as a case study in how seeing works and imagery functions to make revelation a visual process whose devotional life is ongoing.
Interdependent transformations: Integrating insights from relationship science to advance post-traumatic growth and personality change research
Authors: Lamarche Veronica M
Published: June 2021

People have a tremendous ability to grow and change for the better following adverse life events. This capacity for growth has captured the attention of psychologists interested in understanding the mechanisms underpinning both personality and well-being. This paper advocates for a greater integration of relationship science into this area of study as a means of advancing post-traumatic growth and personality change research. Relationships, both as an impetus for change and as evidence of growth, have featured consistently in the post-traumatic growth and adversity literatures. Drawing from interdependence theory in particular, this paper highlights how the unique structure of close relationships and relationship dynamics can be applied to address outstanding theoretical questions related to the advancement of post-traumatic growth research as well as offers a critique of the practice of using relationship outcomes (e.g., connection) as evidence of post-traumatic growth. Finally, this paper encourages psychologists across subdisciplines to share their unique skills and insights to help generate more robust psychological theories and methods.
After the Race to the Top: State and District Capacity to Sustain Professional Development Innovation in Florida
Authors: Akiba Motoko , Howard Cassandra
Published: June 2021

The Race to the Top (RTTT) program incentivized states to use innovation for systemwide improvement of student outcomes, but little is known about how RTTT-funded innovation was sustained after the RTTT program ended. This mixed-methods study examined state and district approaches to sustaining an international innovation called lesson study, a teacher-driven, collaborative, inquiry-based teacher learning process imported from Japan and promoted statewide in Florida. While the state’s role in sustaining lesson study was limited, we found that districts that integrated lesson study into the district instructional system through a clear expectation and strategic adaptation, supported school and teacher ownership of lesson study practice, and provided necessary support and funding were more likely to sustain lesson study. In contrast, the districts that focused on implementation fidelity and district-led facilitation eventually phased out lesson study. Policy implications for sustaining federally funded professional development innovations are discussed.