bluuebunny/crossref_metadata_2025 huggingface dataset:
Extracting relevant patterns from GNSS observations to mitigate multipath in RTK deformation monitoring
Authors: Yiyang Jiang , Jinfeng Wang
Published: May 2024

Employing high precise positioning ability, the Global Navigation Satellite Systems (GNSS) could accurately capture subtle deformations in bridges, supplying critical data for structural health monitoring. However, GNSS antennas placed on bridges often encounter multipath interference generated by bridge deck and water surface reflections, compromising the quality of observation data and positioning accuracy. Through the analysis of GNSS data collected from an operational bridge, we discovered a strong correlation between pseudorange multipath and carrier multipath components. Subsequently, through a series of steps including phase adjustment, decorrelation, and resolution, we successfully mitigated the multipath within residuals, and then reconstructed the corrected residuals into displacements; in addition, the method does not require advance deployment of GNSS equipment to collect calibration information. In terms of positioning results, this method improves by 69.8% compared to the original kinematic resolution and by 32% compared to the least squares method. The residuals of each satellite are reduced by 33.2% compared to kinematic resolution, effectively weakening the multipath interference in carrier phase observations and significantly improving positioning accuracy.
Nab-paclitaxel plus platinum versus paclitaxel plus platinum as first-line therapy in patients with metastatic or recurrent cervical cancer
Authors: liu yuan , Fang Shan-shan , Zhao Run-sheng , Liu Bo , Jin Yi-qiang , Li Quan
Published: May 2024

Purpose
This study aimed to assess the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) plus platinum versus paclitaxel plus platinum as first-line therapy in patients with metastatic or recurrent cervical cancer.
Methods
Between October 2020 and March 2022, consecutive patients with diagnosed with metastatic or recurrent cervical cancer were retrospectively recruited in our hospital. Fifty-four patients were treated with nab-paclitaxel plus cisplatin or carboplatin. Twenty-four patients were treated with paclitaxel plus cisplatin or carboplatin. The two groups were compared for objective response rate (ORR), progression-free survival (PFS), overall survival (OS), and safety. Univariate Cox proportional hazards regression was used to identify the prognostic factors for survival in patients with cervical cancer.
Results
The nab-paclitaxel group showed a higher ORR (72.2% vs 45.8%; P=0.025) than the paclitaxel group. The median PFS was significantly longer in the nab-paclitaxel group than in the paclitaxel group (12 vs 7 months; P=0.041). The median OS was not reached in the nab-paclitaxel group and 15 months in the paclitaxel group, with no statistical difference (P=0.077). The univariate analysis showed that distant organ metastasis and poor ORR were associated with worse PFS and OS (P<0.05). The most common toxicity was hematological adverse events, including grade 3-4 neutropenia, grade 3 anemia and thrombocytopenia in both groups and no statistical differences were observed between the groups (all P>0.05).
Conclusion
Compared with paclitaxel plus platinum, nab-paclitaxel plus platinum may be an effective and tolerable option as first-line therapy for patients with metastatic or recurrent cervical cancer.
Maximizing Tree Diversity in Cocoa Agroforestry: Taking advantage of Planted, Spontaneous, and Remnant Trees
Authors: Kouamé Isaac Konan , N'Guessan Anny Estelle , Dago Marie Ruth , Kouassi Aimé , N'dja Justin Kassi , Aussenac Raphaël , Guei Stéphane , Jagoret Patrick , Traoré Soulemane , Hérault Bruno
Published: May 2024

Cocoa production stands as the primary driver of biodiversity loss in West Africa. In response to this challenge, agroforestry emerges as a promising solution to restore forest cover and preserve biodiversity in agricultural landscapes. Despite distributions of millions of trees to farmers through various sustainability initiatives, survival rates of planted trees have been disappointing in cocoa fields. However, many non-planted trees currently exist in cocoa fields, including trees from spontaneous regeneration and remnants from previous forests. Our study aims to explore the origins of tree biodiversity in current Ivorian cocoa fields and identify the key socio-environmental determinants. Across 150 cocoa fields, more than 10,000 trees were botanically identified, allowing estimation of diversity and complementarity levels between planted, spontaneous, and remnant cohorts, linked to socio-environmental variables within a Bayesian modelling framework. Results revealed that remnant and spontaneous trees exhibited much greater diversity than planted trees, with the latter showing important complementarity with the other cohorts. Moreover, the diversity of each tree cohort was influenced by a distinct set of environmental factors such as climate and soil composition, highlighting the need to consider the unique history and location of each cocoa field to support agroforestry development. Effective biodiversity maximisation thus relies on preserving remnant trees, vital sources of propagules for natural regeneration, while carefully selecting spontaneous trees and complementary introducing planted trees. Furthermore, recognizing the farmer's identity as a key factor shaping observed biodiversity underscores the importance of raising awareness among farmers and offering tree recognition training, particularly for young trees.
Equilibrium exclusive dealing in oligopoly
Authors: Ziss Steffen
Published: May 2024

This paper considers a setting in which upstream oligopolists delegate the retailing of their differentiated products to a set of undifferentiated retailing agents. The downstream market structure is assumed to consist of a set of independent agents that exclusively sell the product of a single manufacturer and a common agent that sells the product of many manufacturers. A three-stage game is considered. In the first stage the manufacturers choose whether to market their products using an independent agent or the common agent. In the second stage the manufacturers set the terms of the two-part tariff contract offered to their agents. In the final stage agents engage in either differentiated Bertrand or differentiated Cournot competition. If the agents engage in differentiated Cournot competition then the model shows that either all manufacturers employ independent agents, or they all employ the common agent. Which of these two equilibria emerge depend on the degree of product substitutability and on the number of manufacturers. If the agents engage in differentiated Bertrand competition, then a third type of equilibrium also emerges in which some firms employ the common agent and others employ independent agents.
Utility of the Dynamic Duo of Ck19 and Cd56 in Cytological Diagnosis of Thyroid Nodules
Authors: Auzumeedi Srikanth , Philpose Rashmi Tresa , Rajampeta Shalini , Mahek Adeenah , Mohammed Abdul Aleem
Published: May 2024

Purpose: Thyroid nodules are a common finding in everyday clinical practice, however only a small percentage is malignant. A cytologic examination is directed toward establishing a precise diagnosis to distinguish malignant or suspicious nodules requiring surgical treatment from those that can be medically managed. Fine-needle aspiration (FNA) is the first choice for diagnostic evaluation of thyroid nodules. It can be a screening test for a large population of patients with nodules, a small group of whom should be considered for surgery. Various ancillary tests have been proposed to help more accurately classify thyroid FNA to prevent unnecessary surgery.The present study was undertaken to evaluate utility of immunoexpression of CK19, and CD56 in the diagnosis of thyroid nodules.
Methods: This was a prospective study conducted over a period of 4 years, in tertiary care referral hospital from 2014 August to 2018. A total of 108 cases were included in the study and the fine needle aspiration cytology smears were subjected to CK19, CD56 immunocytochemistry in 98 cases for evaluation based on adequacy criteria.
Results: CD56 expression was lost in 96.29% of papillary thyroid carcinomas with a sensitivity of discriminating malignant from benign thyroid lesion was 83.87% and specificity of 94.44%. CK19 expression in PTCs with a sensitivity of 92.0% and specificity of 83.3% was noted.
Conclusion: CK19 and CD56 are useful in differentiating benign and malignant thyroid neoplasms, particularly true for differentiating papillary thyroid carcinoma and benign thyroid lesions. Thus, combination of positive marker (CK19) and negative marker (CD56) increases the accuracy of diagnosis of malignancy in cytology with immunocytochemistry.
A novel recombinant begomovirus isolated in Southeast Asia breaks the Ty-1-mediated resistance in tomato
Authors: Pohan Nadya Syafira , Kanae Okuno , Okabe Shoko , Kesumawati Elly , Koeda Sota
Published: May 2024

Infections by begomoviruses have threatened the global production of multiple crops, including Solanaceae species. Recombination, a phenomenon frequently observed in begomoviruses, has profound effects on virus populations, enabling them to adapt to changing environmental conditions. We previously isolated pepper yellow leaf curl Aceh virus (PepYLCAV) from pepper (Capsicum annuum), tomato (Solanum lycopersicum), and tobacco (Nicotiana tabacum) plants in Aceh Province, Indonesia and determined it is a recombinant of the widely distributed pepper yellow leaf curl Indonesia virus (PepYLCIV). To compare PepYLCAV with its major putative parent PepYLCIV in terms of virulence, multiple solanaceous plants (Nicotiana benthamiana, pepper, and tomato) were inoculated with the two viruses. Disease symptom severity, growth inhibition, and viral DNA accumulation were greater for the infection with PepYLCAV than for the infection with PepYLCIV. Furthermore, the inoculation with PepYLCAV revealed the Ty-1-mediated resistance of the begomovirus-resistant tomato cultivar was compromised, resulting in moderate symptoms, which were not detected in the plants infected with PepYLCIV. According to the polymerase chain reaction-based re-analysis of samples collected from fields in Indonesia from 2012 to 2019, PepYLCAV rather than PepYLCIV has been the predominant species since 2017. In conclusion, PepYLCAV, which is a novel recombinant bipartite begomovirus that is more virulent and widespread than its major putative parent (PepYLCIV), can overcome the Ty-1-mediated resistance of commercial F1 hybrid tomato cultivars.
Computed Tomography Assessment of the Conus Medullaris and the Dural Sac Termination in Adult Sheep: Anatomical Implications for Lumbosacral and Sacrococcygeal Injections
Authors: Gutiérrez-Bautista Álvaro , García-Roselló Mireia , Redondo José Ignacio , Moreno-Barragán Mar , García-Vitoria Carles
Published: May 2024

This study aimed to provide information about the conus medullaris (CM) and dural sac (DS) termination points in sheep. Thirteen adult Merino-mixed sheep were anaesthetised and underwent lumbosacral computed tomography (CT) myelography. A spinal injection was administered using a Tuohy needle while the sheep were in sternal recumbency. After confirming the presence of cerebrospinal fluid, 0.4 ml kg-1 iodinated contrast media was injected, and a CT scan was conducted. The analysis focused on determining the vertebrae at which the CM and DS ended. The results showed that in eight cases, the conus ended at the first sacral vertebra, while in five sheep, the termination point was identified at the level of the second sacral vertebra. DS termination occurred in the 3rd sacral vertebra in one animal, the 4th sacral vertebra in another sheep, the 1st caudal vertebra in six cases, and the 2nd caudal vertebra in five cases. The findings highlight the need for caution during lumbosacral injections in sheep, as the CM concludes caudally to this space. It is also essential to be aware that the DS persists caudal to the sacrococcygeal space for safe epidural injections in this region.
Repeat and haplotype aware error correction in nanopore sequencing reads with DeChat
Authors: Luo Xiao , Li Yichen , Chen Enlian , Xu Jialu , Zhang Wenhai , Zeng Xiangxiang , Liu Yuansheng
Published: May 2024

Error self-correction is a pivotal first step in the analysis of long-read sequencing data. However, most existing methods for this purpose are primarily tailored for noisy sequencing data with error rates exceeding 5%, often collapsing true variants in repeats and haplotypes. Alternatively, some methods are heavily optimized for PacBio HiFi reads, leaving a gap in methods specifically designed for Nanopore R10 reads basecalled with high accuracy or super accuracy models, which typically have error rates below 2%. Here, we introduce DeChat, a novel approach specifically designed for Nanopore R10 reads. DeChat enables repeat- and haplotype-aware error correction, leveraging the strengths of both de Bruijn graphs and variant-aware multiple sequence alignment to create a synergistic approach. This approach avoids read overcorrection, ensuring that variants in repeats and haplotypes are preserved while sequencing errors are accurately corrected. Benchmarking experiments reveal that reads corrected using DeChat exhibit substantially fewer errors, ranging from several times to two orders of magnitude lower, compared to the current state-of-the-art approaches. Furthermore, the application of DeChat for error correction significantly improves genome assembly across various aspects. DeChat is implemented as a highly efficient, standalone, and user-friendly software and is publicly available at https://github.com/LuoGroup2023/DeChat
Global burden of ischemic stroke attributable to high body-mass index in 204 countries and territories, 1990–2019
Authors: Guo Xiucai , Zhang Ziping , Yin Xueyan , Xu Qirong , Li Feng , Zhu Feng
Published: May 2024

Background
A high body mass index (hBMI) is one of the major risk factors for ischemic stroke (IS), although independent estimates of the global burden and trend of IS attributable to hBMI are unclear.
Methods
Study data was extracted from the Global Burden of Diseases, Injuries, and Risk Factors Study and analyzed by age, sex, year, and geographical location. The socio-demographic index (SDI) and the human development index (HDI) were used as indicators of national socioeconomic status; Geographic distribution and trend were assessed by calculating the estimated annual percentage change (EAPC); Associations between age-standardized death rate (ASMR) or disability-adjusted life years rate (DALY) and socioeconomic status were analyzed.
Results
Deaths and DALYs increased worldwide from 1990 to 2019, with increases of 79.18% for the former and 96.03% for the latter; the ASMR and ASDR decreased, with ASMR and ASDR-related EAPCs of -1.06 (95% CI: -1.19–-0.92) and − 0.46 (95% CI: -0.60–-0.35), respectively; Women had a higher number of deaths and DALYs, and the majority of deaths and DALYs were shared by those aged ≥ 70. The highest burden rates were shared by Eastern Europe, Central Asia and North Africa and the Middle East; ASMR-related EAPC was associated with ASMR in 1990 (R=-0.36, P < 0.001) and SDI in 2019 in different countries (R=-0.67, P < 0.001), respectively; these patterns were similar to what ASDR had; the HDI in 2019 was associated with ASMR-related EAPC (R=-0.72, P < 0.001) and ASDR-related EAPC in different countries (R= -0.71, P < 0.001).
Conclusions
The number of deaths and DALY of ischemic stroke attributable to hBMI worldwide had increased substantially from 1990 to 2019. Successful population-wide initiatives targeting hBMI may mitigate a wide range of burdens on this disease. Taking into account variations in SDI burden, future prevention and control strategies must be developed and implemented according to country-specific development status.
Non-resonant invariant foliations of quasi-periodically forced systems
Authors: Szalai Robert
Published: May 2024

We show the existence and uniqueness of invariant foliations about invariant tori in analytic discrete-time dynamical systems. The parametrisation method is used prove the result. Our theory is a foundational block of data-driven model order reduction, that can only be carried out using invariant foliations. The theory is illustrated by two mechanical examples, where instantaneous frequencies and damping ratios are calculated about the invariant tori.
MSC codes 34A34 34C45 37M21 37C86
The evolution of lung adenocarcinoma precursors is associated with chromosomal instability and transition from innate to adaptive immune response/evasion
Authors: Zhang Jianjun , Hu Xin , Zhu Bo , Vokes Natalie , Fukuoka Junya , Alvarez Frank Rojas , Heeke Simon , Moreira Andre , Solis Luisa , Haymaker Cara , Velcheti Vamsidhar , Sterman Daniel , Pass Harvey , Cheng Chao , Lee Jack , Zhang Jianhua , Wei Zhubo , Wu Jia , Li Xiuning , Ostrin Edwin , Toumazis Iakovos , Gibbons Don , Su Dan , Fukuoka Junya , Antonoff Mara , Gerber David , Li Chenyang , Kadara Humam , Wang Linghua , Davis Mark , Heymach John , Hanash Samir , Wistuba Ignacio , Dubinett Steven , Alexandrov Ludmil , Lippman Scott , Spira Avrum , Futreal Andrew , Reuben Alexandre
Published: May 2024

Studying lung adenocarcinoma (LUAD) early carcinogenesis is challenging, primarily due to the lack of LUAD precursors specimens. We amassed multi-omics data from 213 LUAD and LUAD precursors to identify molecular features underlying LUAD precancer evolution. We observed progressively increasing mutations, chromosomal aberrations, whole genome doubling and genomic instability from precancer to invasive LUAD, indicating aggravating chromosomal instability (CIN). Telomere shortening, a crucial genomic alteration linked to CIN, emerged at precancer stage. Moreover, later-stage lesions demonstrated increasing cancer stemness and decreasing alveolar identity, suggesting epithelial de-differentiation during early LUAD carcinogenesis. The innate immune cells progressively diminished from precancer to invasive LUAD, concomitant with a gradual recruitment of adaptive immune cells (except CD8+ and gamma-delta T cells that decreased in later stages) and upregulation of numerous immune checkpoints, suggesting LUAD precancer evolution is associated with a shift from innate to adaptive immune response and immune evasion mediated by various mechanisms.
Good husbandry of the cow vet
Authors: Hake Marissa
Published: May 2024

As a new graduate, we often think that honing our technical skills is the number one priority. While being a technically-skilled veterinarian is incredibly important for serving our clients and animals, we also need to develop the skills to take care of ourselves. We can assess our mental and physical states as cattle veterinarians through the lens of the 5 Freedoms and 5 Domains of Animal Welfare. We will discuss how goal setting is a habit of highly successful people and how we often overlook the value of intention setting. As cattle veterinarians, we can combat imposter syndrome through setting boundaries, recog­nizing burnout and investing in relationships. Cattle veterinar­ians, like our bovine patients, are herd animals too.
Consulting through crisis
Authors: Rooney Barnhardt Tera
Published: May 2024

Veterinarians play a vital role in the VCPR for many reasons, but during times of true crisis when so many variables are out­side of any one person’s control, we often are leaned on heavily. This is not a skill we are necessarily equipped with in our for­mal training. This presentation will focus on addressing theses situations beyond our control that impact the well-being of our livestock and those responsible for their care, while also giving insight into protecting the overall health of the entire industry by connecting with consumers who may have concerns about certain crisis in animal agriculture that they may be exposed to by the media.
Spaying/castration: How, complications, pain management
Authors: Osborne Ben
Published: May 2024

Before establishing a business of spaying heifers, you must first be able to understand and explain/sell the benefits of the pro­cedure to your potential clientele. It is a good procedure to add to an existing practice, especially if you are a new grad trying to add value or it can be a solo career opportunity as this skill is one that is currently in short supply. Spaying heifers is a labor-intensive procedure that requires learned skill and technique. It is not for the faint of heart. It is very physically and emotion­ally taxing when you are first starting out. The learning curve is steep and could potentially be expensive early on.
Camelid care essentials: Managing common diseases and disorders
Authors: Miller Blake
Published: May 2024

This presentation aims to highlight crucial aspects of man­aging common diseases and disorders in camelids, focusing on llamas and alpacas. With their unique physiological traits and health requirements, camelids present a distinct set of challenges in veterinary care. By understanding and address­ing these challenges, veterinarians can improve the health and welfare of these animals. The conditions covered include Munge, tooth root abscesses, neurological diseases, choke, ar­thritis, GI obstructions, mites, and intestinal parasites.
OB tips and tricks
Authors: Taylor Karen
Published: May 2024

Dystocias can be one of the more frustrating technical skills to learn. Each dystocia is a little different and it’s difficult to truly get much experience “under the belt” prior to graduation. That being said, there are a few tips that can be used to help increase confidence in the new practitioner.
Understanding financial statements
Authors: Reed Brian
Published: May 2024

Financial statements are used to show the financial perfor­mance and status of businesses of all types. These statements can be used to analyze, manage and improve the performance of a business. It is important for a veterinary business owner or manager to understand what each of the business statements measures within their business. Further, it is important to learn how to use the information presented in the statements to help them manage both the daily business and assist in long term planning for the business. This presentation explains the financial statements and how to use them to make better busi­ness decisions in a veterinary practice and other businesses or organizations a veterinarian may be associated with.
Partial budgets
Authors: Scharping Brandon
Published: May 2024

Utilizing partial budgets can assist veterinarians in making business decisions. It is important for the financial health of a veterinary practice to look at expanding services and thinking critically when purchasing equipment.
This presentation aims to equip veterinarians with the knowl­edge on how to create a partial budget, calculate a break-even point, develop a timeline for implementing a new service, and how to conduct a sensitivity analysis to assess risk.
STUDY ON NANOEMULSION AND MICROEMULSION OF ESSENTIAL OILS: A REVIEW
Authors: Ramesan Nair Haritha
Published: May 2024

Over the years, the interest in nanotechnology and its applications has been increasing, providing numerous benefits to the industries. One such nanotechnology application being used in a majority of industries is the incorporation of nanoemulsion (NE) and microemulsion (ME) in industrial products which act as a carrier/delivery system for some of the active compounds in the product. The incorporation of such emulsion systems helps increase the bioavailability, stability, and interactions of the active compounds in the product. One of the commonly used active components in NE and ME are essential oils (EO)that have a wide range of biological properties used in several fields such as food, pharmaceutical, agriculture, etc. This review intends to provide details on the formulation, stability, and components for the preparation of nanoemulsion and microemulsion. It also deals with understanding the benefits of the incorporation of essential oils into NE/ME.
A RARE CASE OF TRANSMESOCOLIC HERNIATION OF SMALL BOWELTHROUGH A CONGENITAL DEFECT PRESENTING AS A CLOSED BOWEL OBSTRUCTION - A CASE REPORT AND LITERATURE REVIEW OF REPAIRS OF INTERNAL HERNIAS
Authors:   Resident, Department of General Surgery, Pacific Institute of Medical Sciences., Bawa Harleen , Hota Parthasarathi ,   Assistant Professor, MS, FMAS Department of General Surgery, Pacific Institute of Medical Sciences., Lodha Sambhav ,   Professor, MD, FRCR, Department of Radiodiagnosis, Pacific Institute of Medical Sciences., Bishnoi Prikshit ,   Postgraduate Resident, Department of General Surgery, Pacific Institute of Medical Sciences.
Published: May 2024

Transmesocolic hernia is an uncommon type of Internal hernia with incidence ranging from approximately 5â€“10% of all Internal Hernias. To the best of our knowledge, this is the first reported case of a transmesocolic hernia in adults without any surgical history or trauma. Small bowel loops were found herniating into the supracolic compartment through a congenital defect in transverse mesocolon presenting clinically as Small Bowel obstruction. A 20-year-old man was admitted with clinical features of intestinal obstruction. An abdominal X-ray showed multiple small bowel loops with air fluid levels. Contrast-enhanced CT of the abdomen revealed small bowel obstruction not only on the right, but also on the left side of the collapsed descending colon. Emergency Exploratory Laprotomy was performedand bowel loops with discolouration seen enclosed in hernial sac in supracolic compartment which were milked out of defect and observed to have obtained vascularity almost immediately. The postoperative period was uneventful. Preoperative diagnosis of bowel obstruction caused by a transmesocolic hernia remains difficult despite the currently available imaging techniques. Prompt surgery can prevent serious complications such as Bowel gangrene, peritonitis and sepsis.
ANAPHYLACTIC SHOCK DURING HYDATID CYST SURGERY : CASE REPORT
Authors:   Critical Care Unit, Provincial Hospital of Khenifra, Morocco., Elhasnaoui M.A. , Ounci ES. ,   Critical Care Unit, Mohamed VI Academic Hospital, Tangier, Morocco.
Published: May 2024

Intraoperative anaphylactic shock is an unusual complication. Different causes can be involved. Surgery of hydatid cyst is rarely responsible. About a case report of anaphylactic shock due to hydatid cyst surgery, the authors discuss the mechanisms, principles of treatment, and prevention measures of this complication.
Revealing the contribution of corporate sustainability practices to financial performance: Case of BIST Sustainability 25 Index companies
Authors: Serpeninova Yuliia , Lehenchuk Serhii , Zdyrko Nataliya , Zakharov Dmytro , Podolianchuk Olena
Published: May 2024

The purpose of the paper is to study the impact of corporate sustainability practices on the financial performance of companies included in the BIST Sustainability 25 Index. To assess the efficiency and quality of corporate sustainability, general (ESG Disclosure Index) and partial (Environmental Disclosure Index, Social Disclosure Index, and Corporate Governance Disclosure Index) indices were used, calculated based on content analysis of sustainability reports. Based on the two given types of indices and four types of financial performance indicators (return on assets, return on equity, assets turnover ratio, and Tobin’s Q), two types of regression models (GEN models and PART models) were built, and eight analytical models were examined. Company size and leverage were included as control variables in each model. The regression analysis results were contradictory, partially confirming the conclusions of some scientists and refuting the findings of others. A study of GEN models revealed that companies implementing more effective general corporate sustainability practices have a significant positive impact only on return on equity; as for other measures (return on assets, assets turnover ratio, and Tobin’s Q), an insignificant relationship between them and ESG Disclosure Index was found. Results of the PART models analysis revealed a significant positive effect of the Social Disclosure Index on return on equity and assets turnover ratio and a negative relationship between the Corporate Governance Disclosure Index and assets turnover ratio. Using control variables for the two types of models showed a significant negative effect of company size on Tobin’s Q.
AcknowledgmentThis study was supported by the Ministry of Education and Culture of Ukraine within the project “Development of a mechanism for the sustainable development of economic systems in the conditions of military operations and post-war recovery of the economy” (Registration number of the project: 0124U000463).
DESENVOLVIMENTO DE MATRIZ DE SÍLICA AMINOFUNCIONALIZADA COMO POTENCIAL ADSORVENTE DE ÍONS Pt4+ EM SISTEMAS DE PRÉ-CONCENTRAÇÃO PARA ANÁLISE POR FAAS
Authors: do Nascimento Caio , de Araújo Arthur , de Lima Lidiane , de Sousa Filipe , Silva Wagner , Lavorante André , Belian Mônica
Published: May 2024

DEVELOPMENT OF AMINOFUNCTIONALIZED SILICA MATRIX AS A POTENTIAL ADSORBENT FOR Pt4+ IONS IN PRECONCENTRATION SYSTEMS FOR FAAS ANALYSIS. The use of materials such as organofunctionalized silica for application in solid phase extraction (SPE) allows the preconcentration of several ions, including Pt, and subsequent detection. This work aims to synthesize and characterize an organofunctionalized silica (Sil-TMSDT) with the silylant N’(trimethoxysilyl)propylethylenetriamine and its application as a solid phase in the preconcentration Pt4+ ions in aqueous media, using detection by flame atomization atomic absorption spectroscopy (FAAS). The Fourier-transform infrared spectroscopy (FTIR) spectra and scanning electron microscopy (SEM) coupled with energy-dispersive spectroscopy (EDS) confirmed the aminofunctionalization of the silica. For the adsorption process, a preconcentration mini-column with 200 mg of Sil-TMSDT, a solution of 0.485 mg L-1 of K2[PtCl6] at pH 10 and HNO3 0.5 mol L-1 as eluent were used, obtaining an enrichment factor of 15-fold with retention efficiency higher than 99%. The Pt4+ ion determined by FAAS showed a linear response between 0.02 and 0.40 mg L-1; a linear coefficient where R = 0.9981; a 16-fold preconcentration factor; a limit of quantification (LOQ) and limit of detection (LOD) of 0.045 and 0.014 mg L-1, respectively. The proposal system showed analytical applicability to determining Pt4+ ion in an aqueous medium and could be used to detect traces of this potentially toxic metal in biological fluids such as urine and blood.
Increasing the Level of Cognitive Activity of Students of the Secondary Vocational Education System in Computer Science Classes Based on a Collective Learning Method
Authors: Timofeeva K. E.
Published: May 2024

Purpose. The purpose of the article is to substantiate the application of a collective method of teaching in computer science classes in the system of secondary vocational education, contributing to an increase in the level of cognitive activity of students.

Research methodology. The idea of the study is related to the implementation of collective learning methods in computer science classes to increase the level of cognitive activity of students. The use of collective learning methods in computer science classes is considered from three positions: organizational, methodological and diagnostic. The organizational aspect includes the conditions for the formation of student groups and scenarios of their interaction in the learning process. The methodological aspect is related to the selection and preparation of special educational and methodological support, including teaching methods. The diagnostic aspect provides an assessment of the effectiveness of learning the educational material, the level of cognitive activity and the state of the psychological atmosphere in the classroom. The measurement of the level of cognitive activity is carried out with the help of a simplified three-dimensional diagnostic method by O. Markelova. The observation of changes in the psychological atmosphere in the classroom is carried out by the method of pedagogical observation.

Results. Based on the adaptation of the principles and advantages of collective learning methods (according to V. Dyachenko) to the tasks of the secondary vocational education system, the conditions for the formation of student groups and scenarios of their interaction in the process of teaching computer science were outlined. A training cycle has been proposed for the implementation of a collective method of teaching in computer science classes and a collection of digital educational resources has been compiled. Diagnostic tools have been adapted to identify the level of cognitive activity in computer science classes. The diagnosis of the level of cognitive activity and the effectiveness of learning material in computer science classes was carried out, as well as the psychological atmosphere in computer science classes was analyzed.

Conclusions. The use of collective teaching methods in computer science classes in the secondary vocational education system helps to increase the level of cognitive activity of students and, as a result, provides a comfortable psychological atmosphere in the classroom and increases the effectiveness of learning material.
John Zizioulas’ Trinitarian Ecclesiology
Authors: Siwecki Leon
Published: May 2024

The ideas of the Orthodox theologian Bishop John Zizioulas (1931–2023) particularly focus on trinitarian ecclesiology. For him, the Trinity consists of Persons in communion, and the nature of God himself is relational. Trinitarian unity is therefore the prototype, and the Church is its reflection. The essence of the Church is communion, which results from the fact that the Trinity is communion. Zizioulas’ view of the Church is steeped in a trinitarian perspective. Zizioulas pointed out that the Church is based on the double divine economy: the work of Jesus Christ and the work of the Holy Spirit. The relationship of the Holy Trinity with the Church also has consequences for the structure of the Church. In this way, the Church becomes hierarchical in the sense in which the Holy Trinity itself is hierarchical: because of the specificity of the relationship. Becoming a person means breaking down the barriers of individualism and entering into communion life. This is realized in the Church through Baptism and Eucharist. The aim of the article is therefore an attempt to present and evaluate John Zizioulas’ concept of trinitarian ecclesiology.
Ecclesiastical Discipline Concerning the Sermon in the Liturgy of the Roman Rite Celebrated According to the Books of 1962 After the Second Vatican Council
Authors: Pietras Dawid
Published: May 2024

W prezentowanym artykule poruszono zagadnienia prawne związane z kazaniem wygłaszanym podczas liturgii sprawowanej po Soborze Watykańskim II według ksiąg rytu rzymskiego z 1962 roku. W rubrykach tych ksiąg nie traktowano bowiem kazania jako integralnej części liturgii, dlatego jego wygłaszanie miało nierzadko charakter katechizmowy i niehomilijny. Jawi się więc problem badawczy dotyczący uwzględnienia aktualnych norm dyscyplinarnych o homilii, która dziś traktowana jest jako sakramentalny akt kultu. Analizy doprowadziły do wniosku, że kazanie w liturgii celebrowanej według przedsoborowych ksiąg nadal nie jest jej integralną częścią. Należy jednak mieć na uwadze związek głoszonego słowa z celebrowaną liturgią. Wygłaszając kazanie w ramach tych obrzędów, należy przestrzegać norm dyscyplinarnych obowiązującego Kodeksu Prawa Kanonicznego. Powinno się jednak także zachować integralność (kształt) obrzędów zawartych w księgach z 1962 r.
Theological Reflections on Matthew 19:16–26 in Nurturing the Giving Ministry of Generation Z
Authors: Gultom Joni Manumpak Parulian
Published: May 2024

This study aims to reflect on Matthew 19:16–26 as a theological offer to foster the capacity of financial giving practices in spiritual ministry for Generation Z. This is to anticipate the theology of prosperity, which is often misused, and the selfish management of wealth. This theological reflection is essential to understand that Generation Z views spiritual growth separately from the practice of blessing. The impact is that Generation Z needs to care more to support funds in spiritual activities and services around them. The research method applied consists in a descriptive qualitative approach through constructive analysis of scientific discourse. With the use of this method, it is argued that Generation Z needs some basic theological reflection regarding using God’s blessings to give funds and treasures after the COVID-19 pandemic in support of spiritual activities around them.
Preparation of Young People for Confirmation: A Pauline Perspective
Authors: Adamczewski Bartosz
Published: May 2024

Many modern programmes of preparation of young people for confirmation are based on theological models which are correct in theory but ineffective in practice. They often assume that young people come to know the Holy Spirit through catechesis based on Scripture. This article demonstrates that a much better way of preparing young people for confirmation can be found in the genuine letters of Paul the Apostle. He showed that the presence of the Holy Spirit in a human person is not merely a matter of belief, but it can also be experienced in a reliable way, which is not limited to charismatic phenomena. This way is based on the discovery of a number of virtues in young people’s hearts, which are quite unexpected in the context of their human egoism, laziness, etc. For this reason, they must be regarded as the fruit of the Spirit, who broadens human hearts to love and to serve the poor. In this way, young people may also discover Christ – as the one who humbled himself to serve not his social status but people in need.
Chitosan-incorporated Bioceramic-based Nanomaterials for Localized Release of
Therapeutics and Bone Regeneration: An Overview of Recent Advances and
Progresses
Authors: Safarzadeh Sajad , Mozafari M.R. , Naghib Seyed Morteza
Published: May 2024

The usage of nanoparticles in tissue engineering applications has increased significantly
in the last several years. Functional tissues are developed by regulating cell proliferation,
differentiation, and migration on nanostructured scaffolds containing cells. These
scaffolds provide an environment that is more structurally supportive than the microarchitecture
of natural bone. Given its exceptional properties, such as its osteogenic potential,
biocompatibility, and biodegradability, chitosan is a good and promising biomaterial. Unfortunately,
chitosan's low mechanical strength makes it unsuitable for load-bearing applications.
By mixing chitosan with other biomaterials, this drawback might be mitigated.
Bone tissue engineering uses both bioresorbable materials like tricalcium phosphate and
bioactive materials like hydroxyapatite and bioglass. Alumina and titanium are examples of
bioinert materials that are part of these bioceramics. When produced at nanoscale scales, these materials have a
larger surface area and better cell adhesion. This review paper will go into great detail on the bioinert, bioresorbable,
and bioactive nanoceramics-reinforced chitosan scaffolds for bone tissue engineering.
Non-enzymatic Glucose Detection by Fe2O3 Nanorods-reduced Graphene
under Physiological pH
Authors: Yu Jiacai , Shan Xianglu , Zhou Dengfa , Zhao Xueqin , Sheng Weiqin
Published: May 2024

Background:

Non-enzymatic detection has become a research hotspot because of its alternativity
in solving problems compared to enzymatic biosensors, but most of those sensors require
a strong basic pH environment (higher than 10) to active their surface, restricting their use in
clinical detection because the pH of body fluid is around 7.4. Furthermore, metal oxide sensors
with specific morphologies are reported to have a fast electrocatalytic response. Therefore, Fe2O3
nanocomposites with porous structure are selected for glucose detection research in a physiological
pH environment.

Objective:

The study aimed to assess the potential use of porous reduced graphene oxide-Fe2O3
nanorods in glucose detection in a physiological pH environment.

Method:

Hydrothermal method was used to prepare porous Fe2O3-rGO NRs (Nanorods) and hollow
Fe2O3/C nanoparticles. Cyclic voltammetry and electrochemical impedance spectroscopy
were used to evaluate the performance of our materials.

Results:

Porous-reduced graphene oxide-Fe2O3 nanorods have exhibited better performance than
hollow carbon-Fe2O3 core-shell nanoparticles for glucose detection in a physiological pH environment.

Conclusion:

Non-enzymatic glucose sensing based upon cavity Fe2O3-rGO NRs under a physiological
pH environment has been successfully realized, attributing to their high electron mobility
and large specific surface area. Furthermore, the results of this work indicate that the glucose sensor
prepared here has shown good repeatability and stability, which suggests its potential use in
clinical detection.
Can Community Health Workers in Miami Disrupt Disparities among Black People Living with HIV: A Qualitative Analysis
Authors: Kenya Sonjia , Young BreAnne , Richards Lindsay , Casanova Felicia , Rodriguez Allan , Blackmon Jakisha , Carrasquillo Olveen , Pan Yue , Jones-Weiss Deborah
Published: May 2024

Aims

This study aims to understand how clinic-based Community Health Workers could address barriers to viral suppression and improve HIV management among Black people living with HIV.

Background

South Florida is home to the greatest number of people living with HIV (PLH) in Florida, and Black communities are disproportionately impacted. Among the most promising strategies to improve HIV outcomes among Black PLH (BPLH) are Community Health Worker (CHW) interventions. Traditionally, CHWs assist PLH in non-clinical environments, and little data exists on the effects of CHW strategies in clinical settings.

Methods

From March 2021 to January 2022, we administered semi-structured interviews to patients, caregivers, and clinic staff to assess their perceptions of barriers to HIV care, facilitators of HIV care, and views on CHWs using a rapid qualitative analysis framework.

Results

There was significant overlap between clients and providers regarding the perceived barriers and facilitators to HIV care. Emergent themes reflected concepts surrounding HIV policy and clinic limitations, stigma across clinic- and community-based settings, and suggestions on ways CHWs can address these concerns.

Conclusion

The results suggest embedding CHWs into HIV clinical teams may be an efficacious approach to address unmet social needs and overcome systemic barriers to HIV care, leading to improved care engagement and HIV outcomes among BPLH.
Unraveling the Use of Disinformation Hashtags by Social Bots During the COVID-19 Pandemic: Social Networks Analysis
Authors: Suarez-Lledo Victor , Ortega-Martin Esther , Carretero-Bravo Jesus , Ramos-Fiol Begoña , Alvarez-Galvez Javier
Published: May 2024

Background

During the COVID-19 pandemic, social media platforms have been a venue for the exchange of messages, including those related to fake news. There are also accounts programmed to disseminate and amplify specific messages, which can affect individual decision-making and present new challenges for public health.

Objective

This study aimed to analyze how social bots use hashtags compared to human users on topics related to misinformation during the outbreak of the COVID-19 pandemic.

Methods

We selected posts on specific topics related to infodemics such as vaccines, hydroxychloroquine, military, conspiracy, laboratory, Bill Gates, 5G, and UV. We built a network based on the co-occurrence of hashtags and classified the posts based on their source. Using network analysis and community detection algorithms, we identified hashtags that tend to appear together in messages. For each topic, we extracted the most relevant subtopic communities, which are groups of interconnected hashtags.

Results

The distribution of bots and nonbots in each of these communities was uneven, with some sets of hashtags being more common among accounts classified as bots or nonbots. Hashtags related to the Trump and QAnon social movements were common among bots, and specific hashtags with anti-Asian sentiments were also identified. In the subcommunities most populated by bots in the case of vaccines, the group of hashtags including #billgates, #pandemic, and #china was among the most common.

Conclusions

The use of certain hashtags varies depending on the source, and some hashtags are used for different purposes. Understanding these patterns may help address the spread of health misinformation on social media networks.
Accessible Ecosystem for Clinical Research (Federated Learning for Everyone): Development and Usability Study (Preprint)
Authors: Pirmani Ashkan , Oldenhof Martijn , Peeters Liesbet M , De Brouwer Edward , Moreau Yves
Published: May 2024

BACKGROUND

The integrity and reliability of clinical research outcomes rely heavily on access to vast amounts of data. However, the fragmented distribution of these data across multiple institutions, along with ethical and regulatory barriers, presents significant challenges to accessing relevant data. While federated learning offers a promising solution to leverage insights from fragmented data sets, its adoption faces hurdles due to implementation complexities, scalability issues, and inclusivity challenges.

OBJECTIVE

This paper introduces Federated Learning for Everyone (FL4E), an accessible framework facilitating multistakeholder collaboration in clinical research. It focuses on simplifying federated learning through an innovative ecosystem-based approach.

METHODS

The “degree of federation” is a fundamental concept of FL4E, allowing for flexible integration of federated and centralized learning models. This feature provides a customizable solution by enabling users to choose the level of data decentralization based on specific health care settings or project needs, making federated learning more adaptable and efficient. By using an ecosystem-based collaborative learning strategy, FL4E encourages a comprehensive platform for managing real-world data, enhancing collaboration and knowledge sharing among its stakeholders.

RESULTS

Evaluating FL4E’s effectiveness using real-world health care data sets has highlighted its ecosystem-oriented and inclusive design. By applying hybrid models to 2 distinct analytical tasks—classification and survival analysis—within real-world settings, we have effectively measured the “degree of federation” across various contexts. These evaluations show that FL4E’s hybrid models not only match the performance of fully federated models but also avoid the substantial overhead usually linked with these models. Achieving this balance greatly enhances collaborative initiatives and broadens the scope of analytical possibilities within the ecosystem.

CONCLUSIONS

FL4E represents a significant step forward in collaborative clinical research by merging the benefits of centralized and federated learning. Its modular ecosystem-based design and the “degree of federation” feature make it an inclusive, customizable framework suitable for a wide array of clinical research scenarios, promising to revolutionize the field through improved collaboration and data use. Detailed implementation and analyses are available on the associated GitHub repository.