bluuebunny/crossref_metadata_2025 huggingface dataset:
Diversification and distribution of gall crabs (Brachyura: Cryptochiridae: Opecarcinus) associated with Agariciidae corals
Authors: Xu Tao , Bravo Henrique , Paulay Gustav , van der Meij Sancia E. T.
Published: August 2021

Coral reefs are home to the greatest diversity of marine life, and many species on reefs live in symbiotic associations. Studying the historical biogeography of symbiotic species is key to unravelling (potential) coevolutionary processes and explaining species richness patterns. Coral-dwelling gall crabs (Cryptochiridae) live in obligate symbiosis with a scleractinian host, and are ideally suited to study the evolutionary history between heterogeneous taxa involved in a symbiotic relationship. The genus Opecarcinus Kropp and Manning, 1987, like its host coral family Agariciidae, occurs in both Indo-Pacific and Caribbean seas, and is the only cryptochirid genus with a circumtropical distribution. Here, we use mitochondrial and nuclear DNA gene fragments of Opecarcinus specimens sampled from 21 Indo-Pacific localities and one Atlantic (Caribbean) locality. We applied several species delimitation tests to characterise species diversity, inferred a Bayesian molecular-clock time-calibrated phylogeny to estimate divergence times and performed an ancestral area reconstruction. Time to the most recent common ancestor (tMRCA) of Opecarcinus is estimated at 15−6 Mya (middle Miocene—late Miocene). The genus harbours ~ 15 undescribed species as well as several potential species complexes. There are indications of strict host-specificity patterns in certain Opecarcinus species in the Indo-Pacific and Atlantic, however, a robust phylogeny reconstruction of Agariciidae corals—needed to test this further—is currently lacking. The Indo-West Pacific was inferred to be the most probable ancestral area, from where the Opecarcinus lineage colonised the Western Atlantic and subsequently speciated into O. hypostegus. Opecarcinus likely invaded from the Indo-West Pacific across the East Pacific Barrier to the Atlantic, before the full closure of the Isthmus of Panama. The subsequent speciation of O. hypostegus, is possibly associated with newly available niches in the Caribbean, in combination with genetic isolation following the closure of the Panama Isthmus.
Viscoelastic behaviour of highly filled polypropylene with solid and liquid Tin microparticles: influence of the stearic acid additive
Authors: Patti Antonella , Acierno Domenico , Lecocq Hubert , Serghei Anatoli , Cassagnau Philippe
Published: August 2021

In this work, highly filled composites made of a commercial polypropylene resin and low melting point Tin particles, up to 50 vol.% in loadings, have been prepared by melt blending process. The introduction of stearic acid (SA), a common dispersant, was investigated in compositions. The developed systems were characterized in terms of dynamic rheological testing. Final results confirmed a reduction of linear viscoelastic domain, by increasing filler loadings, with an effect more emphasized in the presence of SA. Contrary to literature studies, at equal filler content (50%), both moduli resulted to be superior for formulations containing the dispersing agent. A further rheological characterization continued on systems at 30 vol.% of particle loadings for highlighting differences depending on the SA addition. Specific tests were also performed at temperatures above the melting of Tin particles. Finally, optical microscopic analyses were carried out for gaining insight on sample microstructure, in controlled conditions of temperature and shear rate.
Balanced truncation for model reduction of biological oscillators
Authors: Padoan Alberto , Forni Fulvio , Sepulchre Rodolphe
Published: August 2021

Model reduction is a central problem in mathematical biology. Reduced order models enable modeling of a biological system at different levels of complexity and the quantitative analysis of its properties, like sensitivity to parameter variations and resilience to exogenous perturbations. However, available model reduction methods often fail to capture a diverse range of nonlinear behaviors observed in biology, such as multistability and limit cycle oscillations. The paper addresses this need using differential analysis. This approach leads to a nonlinear enhancement of classical balanced truncation for biological systems whose behavior is not restricted to the stability of a single equilibrium. Numerical results suggest that the proposed framework may be relevant to the approximation of classical models of biological systems.
Systematic review on outcomes used in clinical research on autosomal recessive polycystic kidney disease—are patient-centered outcomes our blind spot?
Authors: Gimpel Charlotte , Liebau Max Christoph , Schaefer Franz
Published: August 2021

Background

Autosomal recessive polycystic kidney disease (ARPKD) is a rare severe hepatorenal disease. Survivors of pulmonary hypoplasia and patients with milder presentations often achieve long-term survival but frequently require kidney and/or liver transplantation.

Objective

To examine the use of clinical, surrogate and patient-centered outcomes in studies on ARPKD with special attention to core outcomes of the Standardized Outcomes in NephroloGy project for children with chronic kidney disease (SONG-Kids).

Data sources and study eligibility criteria

A systematic MEDLINE literature search identified 367 ARPKD studies published since 1990; however, of these 134 were excluded because they did not report any clinical outcomes (e.g. only histopathological, genetic, protein structure or radiological markers), 19 studies because they only included prenatal patients and 138 because they were case reports with ≤ 3 patients.

Study appraisal

Seventy-six eligible studies were examined for study type, size, intervention, and reported outcomes by organ system and type, including all SONG-kids tier 1–3 outcomes.

Participants

There were 3231 patient-reports of children and adults with ARPKD.

Results

The overwhelming majority of studies reported clinical and surrogate outcomes (75/76 (98%) and 73/76 (96%)), but only 11/76 (14%) examined patient-centered outcomes and only 2/76 (3%) used validated instruments to capture them. Of the SONG-Kids core outcomes, kidney function was reported almost universally (70/76 (92%), infection and survival in three quarters (57/76 (75%), 55/76 (72%)) and measures of life participation (including neurological impairment) only rarely and inconsistently (16/76 (21%)).

Limitations

Thirty studies (39%) were of low quality as they were either narrative case reports (n = 14, 18%) and/or patients with ARPKD were an indistinguishable subgroup (n = 18, 24%). Only 28 trials compared interventions, but none were randomized.

Conclusions and implications

Studies that reported clinical outcomes in ARPKD usually covered the core outcome domains of kidney function, infections, and survival, but measures of life participation and patient-centered outcomes are distinctly lacking and require more attention in future trials.

Graphical abstract
Two-phase late Paleozoic magmatism (~ 313–312 and ~ 299–298 Ma) in the Lusatian Block and its relation to large scale NW striking fault zones: evidence from zircon U–Pb CA–ID–TIMS geochronology, bulk rock- and zircon chemistry
Authors: Käßner A. , Tichomirowa M. , Lapp M. , Leonhardt D. , Whitehouse M. , Gerdes A.
Published: August 2021

Late Paleozoic (Variscan) magmatism is widespread in Central Europe. The Lusatian Block is located in the NE Bohemian Massif and it is part of the Saxothuringian Zone of the Variscan orogen. It is bordered by two major NW-trending shear zones, the Intra-Sudetic Fault Zone towards NE and the Elbe Fault Zone towards SW. The scarce Variscan igneous rocks of the Lusatian Block are situated close to these faults. We investigated 19 samples from Variscan plutonic and volcanic rocks of the Lusatian Block, considering all petrological varieties (biotite-bearing granites from the Koenigshain and Stolpen plutons, amphibole-bearing granites from three boreholes, several volcanic dykes, and two volcanites from the intramontane Weissig basin). We applied whole-rock geochemistry (18 samples) and zircon evaporation dating (19 samples). From the evaporation data, we selected six representative samples for additional zircon SHRIMP and CA–ID–TIMS dating. For the Koenigshain pluton, possible protoliths were identified using whole-rock Nd-isotopes, and zircon Hf- and O-isotopes. The new age data allow a subdivision of Variscan igneous rocks in the Lusatian Block into two distinct magmatic episodes. The spatial relation of the two age groups to either the Elbe Fault Zone (298–299 Ma) or the Intra-Sudetic Fault Zone (312–313 Ma) together with reports on the fault-bound character of the dated intrusions suggests an interpretation as two major post-collisional faulting episodes. This assumption of two distinct magmatic periods is confirmed by a compilation of recently published zircon U–Pb CA–ID–TIMS data on further Variscan igneous rocks from the Saxothuringian Zone. New geochemical data allow us to exclude a dominant sedimentary protolith for the Koenigshain pluton as supposed by previous investigations. This conclusion is mainly based on new O- and Hf-isotope data on zircon and the scarcity of inherited zircons. Instead, acid or intermediate igneous rocks are supposed as the main source for these I-type granitoids from the Koenigshain pluton.
Characterizing SPASM/twitch Domain-Containing Radical SAM Enzymes by EPR Spectroscopy
Authors: Balo Aidin R. , Tao Lizhi , Britt R. David
Published: August 2021

Owing to their importance, diversity and abundance of generated paramagnetic species, radical S-adenosylmethionine (rSAM) enzymes have become popular targets for electron paramagnetic resonance (EPR) spectroscopic studies. In contrast to prototypic single-domain and thus single-[4Fe–4S]-containing rSAM enzymes, there is a large subfamily of rSAM enzymes with multiple domains and one or two additional iron–sulfur cluster(s) called the SPASM/twitch domain-containing rSAM enzymes. EPR spectroscopy is a powerful tool that allows for the observation of the iron–sulfur clusters as well as potentially trappable paramagnetic reaction intermediates. Here, we review continuous-wave and pulse EPR spectroscopic studies of SPASM/twitch domain-containing rSAM enzymes. Among these enzymes, we will review in greater depth four well-studied enzymes, BtrN, MoaA, PqqE, and SuiB. Towards establishing a functional consensus of the additional architecture in these enzymes, we describe the commonalities between these enzymes as observed by EPR spectroscopy.
Autobiographical Sketches (2021)
Authors: Möbius Klaus
Published: August 2021

Klaus Möbius gives a selection of his biographical experiences which have shaped his academic and personal life.
Expression of inflammatory mediators in biofilm samples and clinical association in inflammatory bowel disease patients—a preliminary study
Authors: Buchbender Mayte , Fehlhofer Jakob , Proff Peter , Möst Tobias , Ries Jutta , Hannig Matthias , Neurath Markus F. , Gund Madline , Atreya Raja , Kesting Marco
Published: August 2021

Objectives

Inflammatory bowel disease (IBD) has multiple impacts on soft and hard tissues in the oral cavity. The aim of this study was to analyze the expression of cytokines in biofilm samples from patients suffering from IBD and compare them to healthy patients. It was hypothesized that different cytokine expression levels and clinical associations might be drawn.

Material and methods

A total of 56 biofilm samples from three different patient cohorts (group 0 = healthy, HCn = 30; group 1 = Crohn’s disease, CD,n = 19; group 2 = ulcerative colitis, UC,n = 7) were examined for the expression levels of the cytokine interleukins IL-2, -6, and -10; matrix metalloproteinases 7 and 9; and surface antigens CD90/CD11a by quantitative real-time PCR and according to clinical parameters (plaque index, BOP, PD, DMFT, CAL). Relative gene expression was determined using the ∆∆CT method.

Results

The mean BOP values (p = 0.001) and PD (p = 0.000) were significantly higher in the CD group compared to controls. Expression of IL-10 was significantly higher in the CD (p = 0.004) and UC groups (p = 0.022). Expression of MMP-7 was significantly higher in the CD group (p = 0.032). IBD patients treated with TNF inhibitors (p = 0.007) or other immunosuppressants (p = 0.014) showed significant overexpression of IL-10 compared to controls.

Conclusion

Different expression levels of IL-10 and MMP-7 were detected in plaque samples from IBD patients. As only BOP was significantly increased, we conclude that no clinical impairment of periodontal tissue occurred in IBD patients.

Clinical relevance

With the worldwide increasing incidence of IBD, it is important to obtain insights into the effects of the disease on the oral cavity. The study was registered (01.09.2020) at the German clinical trial registry (DRKS00022956).

Clinical trial registration

The study is registered at the German clinical trial registry (DRKS00022956).
Characterization of the subsurface urban heat island and its sources in the Milan city area, Italy
Authors: Previati Alberto , Crosta Giovanni B.
Published: August 2021

Urban areas are major contributors to the alteration of the local atmospheric and groundwater environment. The impact of such changes on the groundwater thermal regime is documented worldwide by elevated groundwater temperature in city centers with respect to the surrounding rural areas. This study investigates the subsurface urban heat island (SUHI) in the aquifers beneath the Milan city area in northern Italy, and assesses the natural and anthropogenic controls on groundwater temperatures within the urban area by analyzing groundwater head and temperature records acquired in the 2016–2020 period. This analysis demonstrates the occurrence of a SUHI with up to 3 °C intensity and reveals a correlation between the density of building/subsurface infrastructures and the mean annual groundwater temperature. Vertical heat fluxes to the aquifer are strongly related to the depth of the groundwater and the density of surface structures and infrastructures. The heat accumulation in the subsurface is reflected by a constant groundwater warming trend between +0.1 and + 0.4 °C/year that leads to a gain of 25 MJ/m2 of thermal energy per year in the shallow aquifer inside the SUHI area. Future monitoring of groundwater temperatures, combined with numerical modeling of coupled groundwater flow and heat transport, will be essential to reveal what this trend is controlled by and to make predictions on the lateral and vertical extent of the groundwater SUHI in the study area.
Pixel-CO2 laser for the treatment of stress urinary incontinence
Authors: Nalewczynska Agnieszka Aleksandra , Barwijuk Michael , Kolczewski Piotr , Dmoch-Gajzlerska Ewa
Published: August 2021

The aim of this study was to assess the safety and efficacy of a minimally invasive pixel-CO2 laser procedure for the treatment of stress urinary incontinence (SUI). This was a prospective, open-label study with a cohort of 59 women. Patients were treated intravaginally with a fractional/pixel CO2 laser every 4–6 weeks for a total of three treatments and assessed at 3, 6, and 12 months. Evaluation tools included a Sandvik severity score based on a validated questionnaire, 1-h pad test, vaginal health index score (VHIS), validated female sexual function index (FSFI), patient’s impression of disease severity (PGI-S), global impression of improvement (PGI-I), and the short-term pelvic floor impact questionnaire (PFIQ-7) to assess improvements in quality of life. Reduction in SUI severity was noticed throughout the duration of the study, as compared to the baseline in which 2% of the patients were defined as “slight,” 73% “moderate,” and 25% “severe.” Gradual improvement of symptoms resulted in redistribution of severity score and the best outcome observed between 3 and 6 months. Sanitary pad weight declined from an average of 35.45 g per day at baseline to 12.47 g at the 3rd treatment, and increased to 23.06 g at 12 months. Vaginal acidity changes showed a similar pattern. No serious adverse events were reported. Pixel-CO2 laser is safe and effective for treating SUI. Additional maintenance treatments should be considered during the 6–12-month post-treatment period in order to maintain the beneficial effects.

Brief summary

Pixel-CO2 laser is a safe and effective treatment for SUI. Maintenance treatments should be considered at 6–12 months.
On augmenting database schemas by latent visual attributes
Authors: Grošup Tomáš , Peška Ladislav , Skopal Tomáš
Published: August 2021

Decision-making in our everyday lives is surrounded by visually important information. Fashion, housing, dating, food or travel are just a few examples. At the same time, most commonly used tools for information retrieval operate on relational and text-based search models which are well understood by end users, but unable to directly cover visual information contained in images or videos. Researcher communities have been trying to reveal the semantics of multimedia in the last decades with ever-improving results, dominated by the success of deep learning. However, this does not close the gap to relational retrieval model on its own and often rather solves a very specialized task like assigning one of pre-defined classes to each object within a closed application ecosystem. Retrieval models based on these novel techniques are difficult to integrate in existing application-agnostic environments built around relational databases, and therefore, they are not so widely used in the industry. In this paper, we address the problem of closing the gap between visual information retrieval and relational database model. We propose and formalize a model for discovering candidates for new relational attributes by analysis of available visual content. We design and implement a system architecture supporting the attribute extraction, suggestion and acceptance processes. We apply the solution in the context of e-commerce and show how it can be seamlessly integrated with SQL environments widely used in the industry. At last, we evaluate the system in a user study and discuss the obtained results.
How well do neurosurgeons predict survival in patients with high-grade glioma?
Authors: Sagberg Lisa Millgård , Jakola Asgeir S. , Reinertsen Ingerid , Solheim Ole
Published: August 2021

Due to the lack of reliable prognostic tools, prognostication and surgical decisions largely rely on the neurosurgeons’ clinical prediction skills. The aim of this study was to assess the accuracy of neurosurgeons’ prediction of survival in patients with high-grade glioma and explore factors possibly associated with accurate predictions. In a prospective single-center study, 199 patients who underwent surgery for high-grade glioma were included. After surgery, the operating surgeon predicted the patient’s survival using an ordinal prediction scale. A survival curve was used to visualize actual survival in groups based on this scale, and the accuracy of clinical prediction was assessed by comparing predicted and actual survival. To investigate factors possibly associated with accurate estimation, a binary logistic regression analysis was performed. The surgeons were able to differentiate between patients with different lengths of survival, and median survival fell within the predicted range in all groups with predicted survival < 24 months. In the group with predicted survival > 24 months, median survival was shorter than predicted. The overall accuracy of surgeons’ survival estimates was 41%, and over- and underestimations were done in 34% and 26%, respectively. Consultants were 3.4 times more likely to accurately predict survival compared to residents (p = 0.006). Our findings demonstrate that although especially experienced neurosurgeons have rather good predictive abilities when estimating survival in patients with high-grade glioma on the group level, they often miss on the individual level. Future prognostic tools should aim to beat the presented clinical prediction skills.
Reciprocal Relationships between Trajectories of Loneliness and Screen Media Use during Adolescence
Authors: Lawrence David , Hunter Simon C. , Cunneen Rebecca , Houghton Stephen J. , Zadow Corinne , Rosenberg Michael , Wood Lisa , Shilton Trevor
Published: August 2021

Adolescence is the peak period for loneliness. Now a ubiquitous part of the adolescent landscape, electronic screens may provide avenues for ameliorating feelings of loneliness. Conversely, they may act as risk factors for the development of such feelings. Although cross-sectional studies to date have investigated the relationship between screen use and loneliness, longitudinal studies are needed if causal and directional associations are to be investigated. Utilising an accelerated longitudinal design and online survey we collected four waves of data from 1919 secondary school adolescents aged 10–15 years over two years. Random intercept cross-lagged panel models tested whether changes in five types of screen use (i.e., total screen time, social media use, gaming, passive screen use, and web use) are associated with changes in loneliness in the subsequent time-point, or changes in loneliness are associated with changes in screen use in the subsequent time-point. We found significant reciprocal associations between screen use and loneliness, with the strongest associations between social networking and electronic gaming and quality of friendships. These findings highlight that any significant increase in an adolescent’s screen use may be a potential indicator of changes in quality of friendships or feelings of isolation.
Evaluation of accuracy, exclusivity, limit-of-detection and ease-of-use of LumiraDx™: An antigen-detecting point-of-care device for SARS-CoV-2
Authors: Krüger Lisa J. , Klein Julian A. F. , Tobian Frank , Gaeddert Mary , Lainati Federica , Klemm Sarah , Schnitzler Paul , Bartenschlager Ralf , Cerikan Berati , Neufeldt Christopher J. , Nikolai Olga , Lindner Andreas K. , Mockenhaupt Frank P. , Seybold Joachim , Jones Terry C. , Corman Victor M. , Pollock Nira R. , Knorr Britta , Welker Andreas , de Vos Margaretha , Sacks Jilian A. , Denkinger Claudia M. ,   ACE-IT Study Group, Assaad K. , Fuhs A. , Harter C. , Schulze C. , Schmitt G. , Klemmer Anja , Müller Rico , Fink Martina , Fougereau Mathilde , Schirmer Maximilian , Small Annika , Meinlschmidt Matthias , Dürr Valerie , Schuckert Alina , Backes Ann-Kathrin , Steinke Salome , Ellinghaus Henrik , Abutaima Loai , Kollatzsch Mandy , Wintel Mia , Kausch Franka , Hommes Franziska , Bölke Alisa , Bernhard Julian , Hülso Claudia , Linzbach Elisabeth , Rössig Heike , Gertler Maximilian , Burock Susen , von dem Busche Katja , Patberg Stephanie
Published: August 2021

Purpose

Rapid antigen-detecting tests (Ag-RDTs) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can transform pandemic control. Thus far, sensitivity (≤ 85%) of lateral-flow assays has limited scale-up. Conceivably, microfluidic immunofluorescence Ag-RDTs could increase sensitivity for SARS-CoV-2 detection.

Methods

This multi-centre diagnostic accuracy study investigated performance of the microfluidic immunofluorescence LumiraDx™ assay, enrolling symptomatic and asymptomatic participants with suspected SARS-CoV-2 infection. Participants collected a supervised nasal mid-turbinate (NMT) self-swab for Ag-RDT testing, in addition to a professionally collected nasopharyngeal (NP) swab for routine testing with reverse transcriptase polymerase chain reaction (RT-PCR). Results were compared to calculate sensitivity and specificity. Sub-analyses investigated the results by viral load, symptom presence and duration. An analytical study assessed exclusivity and limit-of-detection (LOD). In addition, we evaluated ease-of-use.

Results

The study was conducted between November 2nd 2020 and 4th of December 2020. 761 participants were enrolled, with 486 participants reporting symptoms on testing day. 120 out of 146 RT-PCR positive cases were detected positive by LumiraDx™, resulting in a sensitivity of 82.2% (95% CI 75.2–87.5%). Specificity was 99.3% (CI 98.3–99.7%). Sensitivity was increased in individuals with viral load ≥ 7 log10 SARS-CoV2 RNA copies/ml (93.8%; CI 86.2–97.3%). Testing against common respiratory commensals and pathogens showed no cross-reactivity and LOD was estimated to be 2–56 PFU/mL. The ease-of-use-assessment was favourable for lower throughput settings.

Conclusion

The LumiraDx™ assay showed excellent analytical sensitivity, exclusivity and clinical specificity with good clinical sensitivity using supervised NMT self-sampling.

Trial registration number and registration date

DRKS00021220 and 01.04.2020
Machine learning based approach for the interpretation of engineering geophysical sounding logs
Authors: Abordán Armand , Szabó Norbert Péter
Published: August 2021

In this paper, a set of machine learning (ML) tools is applied to estimate the water saturation of shallow unconsolidated sediments at the Bátaapáti site in Hungary. Water saturation is directly calculated from the first factor extracted from a set of direct push logs by factor analysis. The dataset observed by engineering geophysical sounding tools as special variants of direct-push probes contains data from a total of 12 shallow penetration holes. Both one- and two-dimensional applications of the suggested method are presented. To improve the performance of factor analysis, particle swarm optimization (PSO) is applied to give a globally optimized estimate for the factor scores. Furthermore, by a hyperparameter estimation approach, some control parameters of the utilized PSO algorithm are automatically estimated by simulated annealing (SA) to ensure the convergence of the procedure. The result of the suggested ML-based log analysis method is compared and verified by an independent inversion estimate. The study shows that the PSO-based factor analysis aided by hyperparameter estimation provides reliable in situ estimates of water saturation, which may improve the solution of environmental end engineering problems in shallow unconsolidated heterogeneous formations.
Geometry deviation effects of railway catenaries on pantograph–catenary interaction: a case study in Norwegian Railway System
Authors: Song Yang , Jiang Tengjiao , Nåvik Petter , Rønnquist Anders
Published: August 2021

This paper presents a non-contact measurement of the realistic catenary geometry deviation in the Norwegian railway network through a laser rangefinder. The random geometry deviation is included in the catenary model to investigate its effect on the pantograph–catenary interaction. The dispersion of the longitudinal deviation is assumed to follow a Gaussian distribution. A power spectrum density represents the vertical deviation in the contact wire. Based on the Monte Carlo method, several geometry deviation samples are generated and included in the catenary model. A lumped mass pantograph with flexible collectors is employed to reproduce the high-frequency behaviours. The stochastic analysis results indicate that the catenary geometry deviation causes a significant dispersion of the pantograph–catenary interaction response. The contact force standard deviations measured by the inspection vehicle are within the scope of the simulation results. A critical cut-off frequency that covers 1/16 of the dropper interval is suggested to fully describe the effect of the catenary geometry deviation on the contact force. The statistical minimum contact force is recommended to be modified according to the tolerant contact loss rate at high frequency. An unpleasant interaction performance of the pantograph–catenary can be expected at the catenary top speed when the random catenary geometry deviation is included.
Effects of methylenetetrahydrofolate reductase single‐nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilities
Authors: Wang Zheng , Li Kai , Ouyang Ling , Iko Hidasa , Safi Ahmad Javid , Gao Shan
Published: August 2021

Background

Recent studies identifying methylenetetrahydrofolate reductase (MTHFR) polymorphisms associated with breast cancer (BC), ovarian cancer (OC), cervical cancer, and endometrial cancer (EC) have reported conflicting results and been underpowered. To clarify the correlation between MTHFR mutations and these common female malignancies, we conducted a comprehensive meta‐analysis incorporating all eligible publications.

Methods

Relevant reports published before January 20, 2020, were retrieved from PubMed, Embase, the Cochrane Library, and the China National Knowledge Infrastructure databases. The odds ratio and 95% confidence interval summaries for the MTHFR 677C/T and 1298A/C polymorphisms in BC, OC, cervical cancer, and EC were estimated.

Results

A total of 171 studies comprising 56,675 cancer cases and 67,559 controls were included. The results showed a markedly elevated risk of cancer susceptibility related to MTHFR 677C/T based on all genetic models. Similarly, we identified a significant correlation between 1298A/C mutation and cancer risk based on overall comparisons among all models, except the heterozygous model. Moreover, subgroup analysis by cancer type revealed a significantly increased risk of BC associated with 677C/T in the five models and of cervical cancer associated with 1298A/C in some models. Based on ethnicity, significant associations were observed between Asian, African, and mixed populations for 677C/T and the Asian population for 1298A/C. With regard to the sample type used for analysis, we detected a positive association between using blood as the DNA source and cancer risk for 677C/T in all genetic models and for 1298A/C in some genetic models. Further stratification of the results revealed that a notably increased risk was associated with the use of polymerase chain reaction‐restriction fragment‐length polymorphism or TaqMan as the genotyping method, as well as with the use of population‐or hospital‐based groups as the controls for 677C/T and 1298A/C, respectively.

Conclusion

This meta‐analysis suggests that MTHFR 677C/T and 1298A/C polymorphisms correlate with the risk of common gynecological cancers, with these findings potentially applicable for overall comparisons of related data.
The Story of Blood for Shock Resuscitation: How the Pendulum Swings
Authors: Carmichael Samuel P. , Lin Nicholas , Evangelista Meagan E. , Holcomb John B.
Published: August 2021

Whole blood transfusion (WBT) began in 1667 as a treatment for mental illness, with predictably poor results. Its therapeutic utility and widespread use were initially limited by deficiencies in transfusion science and antisepsis. James Blundell, a British obstetrician, was recognized for the first allotransfusion in 1825. However, WBT did not become safe and therapeutic until the early 20th century, with the advent of reliable equipment, sterilization, and blood typing. The discovery of citrate preservation in World War I allowed a separation of donor from recipient and introduced the practice of blood banking. During World War II, Elliott and Strumia were the first to separate whole blood into blood component therapy (BCT), producing dried plasma as a resuscitative product for “traumatic shock.”

During the 1970s, infectious disease, blood fractionation, and financial opportunities further drove the change from WBT to BCT, with few supporting data. Following a period of high-volume crystalloid and BCT resuscitation well into the early 2000s, measures to avoid the resulting iatrogenic resuscitation injury were developed under the concept of damage control resuscitation. Modern transfusion strategies for hemorrhagic shock target balanced BCT to reapproximate whole blood. Contemporary research has expanded the role of WBT to therapy for the acute coagulopathy of trauma and the damaged endothelium. Many US trauma centers are now using WBT as a front-line treatment in tandem with BCT for patients suffering hemorrhagic shock. Looking ahead, it is likely that WBT will once again be the resuscitative fluid of choice for patients in hemorrhagic shock.
Estimated Prevalence and Demographic Correlates of Compulsive Sexual Behavior Among Gay Men in the United States
Authors: Gleason Neil , Finotelli Itor , Miner Michael H. , Herbenick Debra , Coleman Eli
Published: August 2021

Background

Compulsive sexual behavior (CSB) is a clinical syndrome that causes significant distress and impairment for many individuals in the United States. Gay men are thought to have a higher prevalence of CSB, and it is associated with many relevant health outcomes including HIV risk behavior.

Aim

To estimate the prevalence and examine demographic correlates of CSB among gay men in the United States.

Methods

A U.S. national probability sample of 227 gay-identified men were collected as part of the 2015 National Survey of Sexual Health and Behavior (NSSHB).

Outcomes

Participants completed the Compulsive Sexual Behavior Inventory (CSBI-13) and demographic measures.

RESULTS

Eighteen participants (7.93%) scored above the CSBI-13 clinical cut point, indicating they would likely meet criteria for clinically significant compulsive sexual behavior. To assess demographic correlates of CSB, demographic variables were entered into a logistic regression. Results of the logistic regression indicated that participant age, education, and religious affiliation were significant predictors of CSB status. Individuals scoring above the cut point were younger on average (M = 39.17; SD = 14.84) than those scoring below the cut point (M = 47.52; SD = 14.62; P = .02). Odds of scoring above the cut point were about six times greater for religiously affiliated participants compared to non-religiously affiliated participants (P = .005), and four times greater for those who had attended college compared to those who had not (P = .03).

Clinical Implications

These results indicate the prevalence of CSB in gay men is more modest than previously estimated, and is similar to the general population prevalence estimated in a previous study. The strongest predictor of CSB in this sample was religious affiliation, which underscores the importance of evaluating the role of religiosity in the etiology and/or identification of this clinical syndrome.

Strengths and Limitations

These findings are strengthened by the national probability sampling methodology and the use of the empirically validated CSBI-13 cut point. However, this sample was also older and had higher income and educational attainment than the larger population of gay men in the U.S.

CONCLUSION

These results indicate gay men may have a CSB prevalence rate similar to the general population, which contradicts previous research suggesting they are at greater risk for CSB.
The New Art of War
Authors: Weiss Geoffrey F.
Published: August 2021

Many of war's lethal failures are attributable to ignorance caused by a dearth of contemporary, accessible theory to inform warfighting, strategy, and policy. To remedy this problem, Colonel Geoffrey F. Weiss offers an ambitious new survey of war's nature, character, and future in the tradition of Sun Tzu and Clausewitz. He begins by melding philosophical and military concepts to reveal war's origins and to analyze war theory's foundational ideas. Then, leveraging science, philosophy, and the wisdom of war's master theorists, Colonel Weiss presents a genuinely original framework and lexicon that characterizes and clarifies the relationships between humanity, politics, strategy, and combat; explains how and why war changes form; offers a methodology for forecasting future war; and ponders the permanence of war as a human activity. The New Art of War is an indispensable guide for understanding human conflict that will change how we think and communicate about war.
Gendered access to land and household food insecurity: Evidence from Nigeria
Authors: Nnaji Amaka , Ratna Nazmun N. , Renwick Alan
Published: August 2021

In this article, we examine the joint influence of land access and gender of household head on household food insecurity by employing a logit model and using data from the 2015/2016 Nigerian General Household Survey. Our results show that female-headed households (FHHs) are more food insecure than male-headed households. However, with a 1-acre increase in their access to land, FHHs are 16 percent less likely to be food insecure. This finding provides policy insights into how improving access to arable land for land-poor FHHs can enhance food security in Nigeria.
Sodium Valproate Versus Dopamine Antagonists for Acute Migraine in the Emergency Department: A Systematic Review
Authors: Viau J. Alexander , Patel Dilan , Cheng Wei , Cortel-LeBlanc Miguel , Nath Avik , Perry Jeffrey J.
Published: August 2021

Background:

Migraine is a common primary headache disorder diagnosed in the emergency department (ED). This systematic review sought to compare the efficacy of sodium valproate (SV) to dopamine antagonists (DA) in relieving pain due to acute migraine.

Methods:

Two research librarians helped create a search strategy including Embase, Ovid Medline, and the Cochrane Database of Clinical Trials from inception to June 1, 2020, updated May 19, 2021. Two investigators identified randomized control trials (RCTs) including adult patients with acute migraine presenting to the ED or acute clinical setting comparing SV to a DA with the aim of relieving pain. Primary outcome was headache relief at 1 hour from treatment. Secondary outcomes included pain relief at 24 hours, relief of associated symptoms (e.g. nausea, photo-/phonophobia, etc.), and need for rescue analgesia. Meta-analysis was performed and presented as odds ratios.

Results:

Four RCTs with 470 patients were identified from an initial pool of 454 titles. Two studies compared SV to a DA alone and two compared SV to a DA plus one other agent (sumatriptan or dihydroergotamine). Three studies were included for meta-analysis. Pain relief had a pooled odds ratio of 1.14 at 1 hour and 0.42 at 24 hours. Three articles reporting the need for rescue analgesia had pooled odds ratio of 2.76.

Conclusions:

Sodium valproate is not more effective than DA at reducing migraine headache pain at 1 hour and less effective at 24 hours. Dopamine antagonists should be used over SV for the management of patients with acute migraine.
A redescription ofStenoporaand the type speciesStenopora tasmaniensisLonsdale, 1844 (Trepostomata, Bryozoa)
Authors: Reid Catherine M.
Published: August 2021

Type material forStenopora tasmaniensisLonsdale, 1844 was lost in the late nineteenth century, and subsequent descriptions of the genus have been based on material incorrectly assigned to the type species. A neotype is erected forS. tasmaniensisfrom the original type locality and the genus redescribed. The genus exhibits ramose, frondescent, encrusting, and massive colony morphologies, diaphragms are absent, and acanthostyles of a single size surround each aperture. This single size of acanthostyles aligns with the original type species description; however, it differs from the subsequently accepted genus description and may result in existing species being removed from the genus. Analysis of zooecial characters of a single colony exhibiting both frondescent and ramose morphologies reveals statistically significant differences between subsampled sections, despite being from the same colony. Differences relate to details of zooecial parameters and are not controlled by colony morphology. This variation within a single colony confirms the importance of using qualitative characters alongside quantitative measures in defining Paleozoic bryozoan species.
SOME QUESTIONS OF UNIFORMITY IN ALGORITHMIC RANDOMNESS
Authors: BIENVENU LAURENT , CSIMA BARBARA F. , HARRISON-TRAINOR MATTHEW
Published: August 2021

The
$\Omega $
numbers—the halting probabilities of universal prefix-free machines—are known to be exactly the Martin-Löf random left-c.e. reals. We show that one cannot uniformly produce, from a Martin-Löf random left-c.e. real
$\alpha $
, a universal prefix-free machine U whose halting probability is
$\alpha $
. We also answer a question of Barmpalias and Lewis-Pye by showing that given a left-c.e. real
$\alpha $
, one cannot uniformly produce a left-c.e. real
$\beta $
such that
$\alpha - \beta $
is neither left-c.e. nor right-c.e.
Prospective association of confectionery intake with depressive symptoms among Japanese workers: the Furukawa Nutrition and Health Study
Authors: Shimmura Nao , Nanri Akiko , Kashino Ikuko , Kochi Takeshi , Eguchi Masafumi , Kabe Isamu , Mizoue Tetsuya
Published: August 2021

High intake of sweet foods such as cakes, cookies, chocolate and ice cream has been reported to be associated with depressive symptoms. However, prospective studies are scarce and no study has been conducted in Asian populations. We prospectively investigated the association between confectionery intake and depressive symptoms in a Japanese working population. Participants were 911 workers (812 men and 99 women; aged 19–68 years) without depressive symptoms at baseline who completed a 3-year follow-up survey. Dietary intake was assessed using a validated self-administered diet history questionnaire. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Multiple logistic regression was used to estimate the OR of depressive symptoms according to tertile of confectionery intake with adjustment for covariates. At the time of the 3-year follow-up survey, 153 (16·8 %) workers were newly identified as having depressive symptoms (CES-D score ≥ 16). Confectionery intake was significantly associated with increased odds of developing depressive symptoms. The multivariable-adjusted OR of depressive symptoms for the highest v. lowest tertile of confectionery intake was 1·72 (95 % CI 1·03, 2·86) after adjustment for covariates including dietary factors such as folate, vitamin B6, vitamin B12, n-3 PUFA, Mg, Zn and soft drink (Pfor trend = 0·012). Our results suggest that confectionery intake is associated with a higher risk of depressive symptoms in a Japanese working population predominantly comprised of men.
Policy Ideology and Local Ideological Representation in Canada
Authors: Lucas Jack , Armstrong David A.
Published: August 2021

To enable new research on local ideology and representation in Canada, we construct a latent measure of the policy ideology of 37,500 Canadian Election Study respondents using 56 policy-relevant questions and then use multilevel regression and poststratification to estimate the average ideological position of each of Canada's 338 federal electoral districts and 250 largest municipalities. We use these local ideology estimates to examine ideological representation in Canadian municipal politics. Combining our municipal ideology estimates with elite survey data from more than 900 Canadian municipal politicians, we find evidence of a strong relationship between mass and elite ideology. This relationship is consistent across differing municipal population sizes and institutional structures. We conclude with additional detail on our publicly available individual and aggregate measures and describe their potential uses for future research on ideology and representation in Canadian politics at all levels.
Milk metabolites, proteins and oxidative stress markers in dairy cows suffering from Staphylococcus aureus subclinical mastitis with or without spontaneous cure
Authors: Tabatabaee Nasim , Heidarpour Mohammad , Khoramian Babak
Published: August 2021

Our objective was to evaluate relationships between milk components (acute phase proteins, enzymes, metabolic parameters and oxidative indices) and the spontaneous cure outcome of Staphylococcus aureus subclinical mastitis in dairy cows. The values of haptoglobin, serum amyloid A (SAA), malondialdehyde (MDA), total antioxidant capacity, milk urea nitrogen (MUN), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), electrolytes (Cl and K), total protein, albumin, α-lactalbumin, β-lactoglobulin, and immunoglobulin were measured in milk samples of S. aureus subclinical mastitis cows with spontaneous cure (n = 23), S. aureus subclinical mastitis cows without spontaneous cure (n = 29) and healthy cows (n = 23). The comparison of measured parameters revealed that subclinical mastitis cows with spontaneous cure had lower ALP and haptoglobin concentrations both at diagnosis and after cure (P < 0.05). In contrast, total antioxidant capacity and MDA concentration in subclinical mastitis cows without spontaneous cure significantly increased with time (P < 0.05). We can suggest that elevated haptoglobin concentration and higher ALP activity indicative of enhanced oxidative stress could potentially serve as early diagnostic indicators of chronic disease and the persistence of S. aureus subclinical mastitis in dairy cows.
First description of aRaphidascarisspecies (Nematoda: Raphidascarididae) in a mudskipperApocryptes bato(Actinopterygii: Gobiidae) from West Bengal, India
Authors: Patra B.K. , Choudhury A. , Thorn R. , Ash A.
Published: August 2021

A new nematode species,Raphidascaris mundeswariensisn. sp. (Raphidascarididae), is described from male and female specimens found in the intestines of the mudskipperApocryptes bato(Hamilton, 1822) (Gobiidae) from the Mundeswari River of West Bengal, India. This species is distinguished from its congeners by 214–255-μm-long spicules, 14 pairs of preanal papillae of two markedly different sizes, one pair of adanal papillae, six pairs of postanal papillae and the absence of lateral alae. Phylogenetic analyses using partial sequences of the 28S ribosomal RNA gene place the new species in a clade containingRaphidascaris gigi,Raphidascaris lophii,Raphidascaris longispiculaand two species ofHysterothylacium. The molecular analyses also corroborate results of previous studies that have foundRaphidascarisandHysterothylaciumto be paraphyletic. The finding ofR.mundeswariensisinA.batois the firstRaphidascarisspecies described from a mudskipper anywhere.
The USSR and Africa
Authors: Desfosses Helen
Published: August 2021

Soviet African Policy is currently in a consolidation phase. It is true that the 1970's brought the Soviet Union great military and political successes in Angola and Ethiopia — successes which signaled not only a new stage in Soviet strategic capabilities but also a new ability and willingness to influence events far from its borders. However, these triumphs should not blind us to the constraints under which the USSR has labored, the resulting limits on its influence, and the ensuing move away from interventionist activism.
Can an Aid Bureaucracy Empower Women? The Case of Sida
Authors: Himmelstrand Karin
Published: August 2021

At the NGO African Women's Task Force Meeting in Nairobi in April 1988, Sara Longwe suggested that the “main problem in Africa is to shift women's development above the welfare level in the face of resistance from male dominated government bureaucracies.” She also maintained that ”… women's welfare is not likely to be much improved until the affected women themselves achieve control in such areas as control over factors of production and distribution of income and benefits… This dimension is concerned with women's power to control their own lives and become independent and self-reliant — both individually and collectively — on equal terms with men. Equality in control is the ultimate objective of the process of empowerment.“
Debt and Structural Adjustment in Africa: Realities and Possibilities
Authors: Callaghy Thomas M.
Published: August 2021

Since the middle of the 1970s Sub-Saharan African states have focused increasingly on their severe economic and fiscal crises. These involve wrestling with the burdens of debt service and the rigors of rescheduling, conducting difficult negotiations with bilateral and private creditors, bargaining over conditionality packages with the International Monetary Fund and the World Bank or fending them off, distributing the painful costs of adjustment, coping with import strangulation and devising new development policies and strategies. Already highly dependent on the outside world, the intensity, stakes and levels of conditionality of these relations with external actors have increased substantially.