bluuebunny/crossref_metadata_2025 huggingface dataset:
Categories of general, special and singular in criminal law: semantic analysis
Authors: Kulikov Egor Alekseevich
Published: February 2021

The subject of the study is the regularities of the interaction of the categories of subjective dialectics with the fundamental concepts of Russian criminal law. The criminal law is based on linguistic structures, in connection with which the article is devoted to the linguistic aspects of the categories of general, special and singular. Some attention is paid to analytical philosophy and analytical jurisprudence. The linguistic turn in epistemology and epistemology of the mid-20th century drew attention to the linguistic side of various texts, justified the need to study this side, since language and communication form the basis of human interaction, determine the content and development of social relations. In the future, a significant part of the research, including on criminal law topics, is devoted to the language of the law and legislative language systematics. The lexical meaning of the words "general", "singular", "separate", "separate", "separate", "special", "generalize" is considered, their content from the point of view of etymology, word formation, synonymy is revealed. Some attention is paid to the meaning of the sought terms in the social sphere. The question of the categories of dialectics in criminal law is raised extremely rarely, the categories of general, special and singular mentioned in the article have not been practically studied. From a linguistic point of view, these categories can not always be distinguished from each other, they often overlap in content, and in order to determine their legal aspects, i.e. manifestations in the field of jurisprudence, one semantic characteristic is not enough, it can only be considered as a stage of research. Semantic aspects of categories set guidelines for clarifying their philosophical and special scientific content, explain the options for possible word usage, outline its boundaries.With the help of language characteristics, the research range is set, i.e., to distinguish from related concepts and terms already at the initial stage of research. In the process of interpreting the criminal law, the lexical method acts as the leading one and, along with the systemic one, allows you to understand the meaning of legal prescriptions as accurately as possible.
Poetry of Boris Kagermazov
Authors: Bozieva Naima Borisovna
Published: February 2021

The subject of this article is the analysis of poetry of Boris Kagermazov. The object of this research is the genre, plot, composition, and thematic peculiarities the epic works of Boris Kagermazov. The goal of this article is to reveal the specific features of the poems, their compositional structure, novelties s in poetics, and role of this genre in the works of Boris Kagermazov. Detailed examination is conducted on peculiarities of the poems “Echo of the War”, “Grief and Anger”, “Harmonist”. Attention is given to the analysis of poetic theme and problematic of the poems, as well as to their composition and artistic skill of B. Kagermazov. The relevance of the selected topic is defined by the crucial role of B. Kagermazov in evolution of the genre of poem in the Kabardian-Circassian literature of the XX century, the depth of artistic conceptualization of the historical process, and embrace of the system of philosophical, spiritual- ethical, and aesthetic values of his ethnic group. The acquired results may serve as the theoretical foundation in the further examination of the works of B. Kagermazov and studying the Adyghe poetry, namely lyrical and lyrical-epic works; their practical application can be found in specialized courses, research works of the pedagogues, postgraduates and students. The conclusion is made on the novelties introduced by the poet in creation of original modifications of the poem, which is reflected in the diffusion of genres, simultaneous use of certain elements of lyrics, epic, and drama. The poet's artistic pursuits made significant contribution to enrichment of the national literature.
Narrative analysis of media discourse of a special event (on the example of Robert Rozhdestvensky Altai Regional Literary Festival)
Authors: Milyukova Anna
Published: February 2021

Leaning on the narrative analysis of media materials, this articled examines the peculiarities of the narrative of regional literary festival of Robert Rozhdestvensky. Research methodology employs narrative analysis, which being a variety of qualitative content analysis, implies characteristics of the following textual elements: narrator: hero/narrator / author; characters, their types; events (plot functions); type of narrative strategy; time; space; intertext, precedent texts, metanarrative; dichotomies, presuppositions, ideologemes. The object of this analysis is media article dedicated to the regional literary festival of Robert Rozhdestvensky, material publications (345 units) cover the period from June 8, 2007 to December 31, 2019. Four types of narrative elements of discourse of a special event are characterized: personal experience of familiarization with R. Rozhdestvensky’s poetry; national narrative of the Great Patriotic War; history of emergence of his poems in the context of other belongings that were transferred to the museum. Narrative elements within the discourse structure are brief and curtailed. The article explores narrative potential of a social conflict in generating the narrative of a special event in the media. It is demonstrated that the narrative is composed by stories associated with Robert Rozhdestvensky, while the subjects of media discourse are the prominent participants, cultural workers, and narrators. The conclusion is drawn that the narrative and mythological components within the structure of media discourse are attributed to different objectives.
Peculiarities of genesis of the classical phrase particles of Chinese language
Authors: Pavlova Alena Dmitrievna , Guruleva Tatiana Leonidovna
Published: February 2021

This article is dedicated to the evolution of phrase particles in Chinese language. The goal consists in examination of genesis of the classical phrase particles of Chinese language and their development patterns. The article also describes the origins of phrase particles, which were established as a result of analysis of the genesis. The relevance of this research is substantiated by the need for diachronic analysis of the particles in order to understand the essence and peculiarities of the functionality of modern particles. Recent years indicate heightened interest to learning Chinese language. The requirements to the level of formation of the Chinese linguistic personality in the process of teaching Chinese language at schools and universities have also grown significantly. Phrase particles play an important role in the development of communicative competence of the learners of Chinese language. Leaning on the existing theoretical works and written sources, the author analyzes the particles of Putonghua from the III century BC until the eary XX century was performed, as well as reconstructs the process of formation and development of the modern classical phrase particles (啊，吗，吧，呢，了，的). The conclusions are formulated on the origins of classical phrase particles of Chinese language and their development patterns; description is given to the peculiarities of formation of each of the classical phrase particles.
Atenção às pessoas com hanseníase frente a pandemia da covid-19: uma revisão narrativa
Authors: Silva Juliana Macêdo dos Santos , Do Nascimento Diana Cardeal , Moura Jenny Caroline Vieira , De Almeida Vivian Ranyelle Soares , Freitas Maria Yaná Guimarães Silva , Dos Santos Sélton Diniz , Melo Andreia Macêdo dos Santos , Silva Deisiane Almeida Cerqueira , Dias Jamille Soares , Da Silva Igor Rafael Souza
Published: February 2021

Objetivo: Descrever sobre a atenção às pessoas com hanseníase frente à pandemia da COVID-19 por meio de uma revisão narrativa. Revisão Bibliográfica: A hanseníase constitui uma doença que requer tratamento prévio, completo e sem interrupção, evitando assim, deformidades e incapacidades físicas permanentes. Com a pandemia por COVID-19 houve mudanças na vida das pessoas para adequação da nova realidade vivenciada mundialmente no intuito de conter a disseminação da doença o que em sobremaneira afetará também, outros agravos, inclusive a estratégia de eliminação da hanseníase. Sendo assim, para garantir o tratamento da hanseníase assim como a descoberta de casos novos, os serviços de saúde precisaram estabelecer adequações nos processos de trabalho dos profissionais e estratégias para atendimento aos pacientes. Além disso, o Ministério da Saúde liberou notas técnicas para as Unidades Federativas sobre condutas a serem adotadas com os pacientes de reação hansênica. Considerações finais: Os profissionais de saúde devem trabalhar em conjunto, adotando ações de assistência para que a eliminação da hanseníase não se perca com o direcionamento de recursos para a COVID-19.
Oncological cosmetics formulations based on medicinal plants
Authors: Gonçalves Gisele Mara Silva , Da Silva Adeline Leonello
Published: February 2021

Objective: Developing dermocosmetic formulations to minimize the harmful and/or undesirable effects of chemotherapy on the skin. Methods: Vegetable compounds with proven hydrating, emollient, anti-inflammatory and antimicrobial action were selected: extracts or tinctures of Arnica montana L., Calendula officinalis L., Punica granatum and Rosmarinus officinalis L. Two formulations were proposed, cream and gel-cream, evaluated for accelerated stability and preservation challenge test, with inoculation of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, and evaluation for 28 days. Results: The formulations were considered adequate and the proposed objective was achieved, developing two novel formulations, a cream and a gel-cream, which can compose an innovative product line that meets the needs of the cancer patient. Conclusion: The cream formulation was proposed for epidermal cell renewal and skin moistening, containing the combination of pomegranate tincture (Punica granatum) and marigold glycolic extract (Calendula officinalis), while the gel-cream formulation has anti-inflammatory potential provided by rosemary tincture (Rosmarinus officinalis) and arnica tincture (Arnica montana). The formulations were stable, having the potential to improve the life quality of cancer patients.
Interfaces da presença familiar no tratamento da criança gravemente enferma
Authors: Cieslak Gabriele , Martins Tereza Cristina de Lima , Berté Mari Ângela , Makuch Débora Maria Vargas
Published: February 2021

Objetivo: Descrever as interfaces da presença familiar em contexto de terapia intensiva pediátrica (UTIP) durante o tratamento da criança gravemente enferma. Métodos: Estudo exploratório descritivo, com abordagem qualitativa; coleta de dados se deu por meio de entrevista semiestruturada. Participaram do estudo, 17 familiares de pacientes em UTIP em uma instituição de grande porte exclusivamente pediátrica, no estado do Paraná, entre os meses de Março e Julho de 2020. Para análise das informações, optou-se pela metodologia de Minayo MCS (2007). Resultados: As entrevistas em sua maioria (70,6%) foram realizadas em UTIP cardiológica, sendo 64,7% das participantes mães, com idade média de 18 a 29 anos (53%) e tempo de internação de 1 até 29 dias (64,7%). Os discursos entre UTIP cardiológica e UTIP cirúrgica, apresentaram semelhanças emergindo duas unidades de contexto: Presença Familiar em Terapia Intensiva Pediátrica: enfrentamento e adaptação, descreve-se a vivência dos familiares e processos adaptativos a luz de Roy; e a Segurança do Paciente Pediátrico: interface familiar, sendo encontrado discursos de qualidade assistencial. Conclusão: A inclusão efetiva do familiar no processo assistencial permite melhor enfrentamento e adaptação, os familiares coadjuvam com os mecanismos de modulação da resposta hormonal do paciente promovendo melhores desfechos clínicos e melhor resposta terapêutica.
Pleural effusion in hematological pathology
Authors: Yerrapotu Neeraja , Rahman Abid , Gabali Ali , Shidham Vinod B
Published: February 2021

A 51-year-old male with a history of chronic myelomonocytic leukemia-2 (CMML-2) presented with fatigue, night sweats, dyspnea, and right-sided chest pain exacerbated by deep breath. Computed tomography scan demonstrated right-sided pleural effusion with atelectasis. Pleural fluid cytology showed reactive mesothelial cells mixed with atypical cells [Figure 1]. The immunostains are performed using the SCIP approach.[1] The atypical cells were immunoreactive for vimentin, CD68, and CD163, while non-immunoreactive for cytokeratin, calretinin, BerEP4, and MOC31.
Assessing the impact of COVID 19 on male fertility: A systematic review
Authors: Singh Neeta , Sethi Ankita
Published: February 2021

Coronavirus disease 2019 (COVID-19) infection is presently a global pandemic; it is mainly an acute respiratory infection. It can affect various organs of the body, primarily the lung, GI tract, and CVS and can even affect the urinary system and male reproductive system. A systematic search using PubMed, EMBASE, and Scopus was performed using the keywords and Boolean operators. There were 55 studies, which were found to be relevant to the search conducted in the above-mentioned databases. Out of the 55 studies, 32 were identified to be fitting the inclusion and exclusion criteria of the review. Recent studies have conflicting results on the presence of COVID-19 in the semen of patients who were reverse transcription polymerase chain reaction (RT-PCR) positive for COVID-19. Majority studies negate COVID-19 infection in semen as per RT-PCR, but semen parameters are adversely affected especially in moderate cases. One study states that RT-PCR is positive in few semen samples of severe cases. Testes have high angiotensin-converting enzyme 2 (ACE2) expression and transmembrane serine protease 2 is essential for priming of the spike (S) protein in COVID-19 virus and it is concentrated in spermatogonia and spermatids, which means if spermatogonia is infected with COVID-19 and it hampers the spermatogenesis, it can lead to dysfunction of the male reproductive system. There is evidence of high ACE2 expression in renal tubules, which means there can be renal tubular damage because of COVID-19 infection and there is a possibility of shedding of virus in urine. The COVID-19 detected in the semen could also be because of shedding of virus from the urinary tract in men. The authors thus conclude that there is a need larger study to answer the questions like whether the COVID-19 infection just present in the semen or it is attached to the spermatozoa or its present inside the cells because of interaction of COVID-19 S protein and ACE2 receptor on the spermatogonia. If COVID-19 infection is detected in the semen, then whether it can be removed from the semen by the sperm washing techniques and is it safe to use in ART procedures or any other fertility treatment.
Renin-angiotensin system: A possible clue for gender bias in coronavirus disease 2019 infection
Authors: Padmanabhan Renjini Ambika , Laloraya Malini
Published: February 2021

The novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), has been declared as a pandemic by WHO on March 11, 2020. Previous history of viral infections such as Middle East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV had shown high risk for maternal and neonates, with vertical transmission (VT) and perinatal as well as maternal mortality; hence, the possibility of the same cannot be ruled out in case of COVID-19. Authors’ literature survey on Scopus/Embase/ PubMed/Google using the terms “COVID-19* and pregnancy, VT, and gender difference in COVID-19 infection. All the relevant literatures were included in this review. Like other respiratory infections made by coronavirusesMERS-CoV and severe acute respiratory syndrome coronavirus 2 (SARS-CoV), the Viral spike of SARS-Cov-2 catches angiotensin converting enzyme 2 (ACE2) (a part of renin angiotensin system [RAS]) to enter the body. For those with risk factors, namely, cardiovascular complications, diabetes, and respiratory disorders, this entry is fatal We suggest that pregnancy is a well-orchestrated event capable of tackling COVID-19 infection by virtue of its hormone dependency which is capable of curbing the cytokine storm despite increased ACE2 expression. This review summarizes the gender bias of RAS; importance of RAS in pregnancy and sex hormonal influence on COVID-19 infection.
Impact of coronavirus disease 2019 on diabetic patients: An endocrinological perspective for better management
Authors: Agrawal Himanshu , Das Neeladrisingha , Nathani Sandip , Roy Partha
Published: February 2021

The current pandemic of coronavirus disease 2019 (COVID-19) has led to severe health-related distress globally. Worldwide, different vaccines have been proven safe and effective against COVID-19. However, at present, immunization is permitted for the individuals involved in health sector in India and therefore still requires special care. Elderly people especially with other chronic ailments are the most vulnerable population for this infection. Diabetes is one such ailment which makes an individual more vulnerable toward this viral infection and if infected, the chances of survival of such individuals are very low. In the current review, we have discussed the endocrine aspects which might be responsible for the high mortality rate due to COVID-19 in diabetic patients.
Do pets transmit SARS-CoV-2 to humans, including pregnant women and infertility patients?
Authors: Bajwa Kamlesh Kumari , Bansal Sonu , Parashar Atul , Dua Seema , Kumar Dharmendra , Selokar Naresh L.
Published: February 2021

Humans are closely associated with companion animals, particularly dogs, and cats. Recent studies demonstrated that pets could succumb to the coronavirus disease 2019 (COVID-19) virus infection through a person who has COVID-19 disease. At present, we do have strong evidence of how COVID-19 affects pets and do the pets transmit the virus to humans. Until we know more about virus transmission, we need to follow the health agency guidelines to contain the virus spread. In this short perceptive article, we describe the incidences of coronavirus in pets and possible precautions that need to be followed by people, particularly pregnant women and infertility patients to avoid getting the disease.
World’s outlook for consequences of COVID-19 infection on reproductive robustness and assisted reproductive techniques
Authors: Minhaj Humaira , Rozati Roya , Balaji Avvari Bhaskara , Gautam Ayapathi Mehdi , Aiman Vikram , Ali Mohammed Akbar
Published: February 2021

The appearance of new coronavirus infection COVID-19 that made an appearance in Wuhan (China) in the month of December 2019 has developed in an epidemic disease which has swiftly inflated and presented unique distress and potential risks to females that are pregnant or those who choose childbearing throughout the world. Even though, none of the professional associations have furnished directions that the females have to keep away from conception during the current pandemic situation, innumerable professional establishments have endorsed a moratorium in regard to infertility aids. We have done a review regarding the effect of COVID-19 disease on assisted reproductive techniques. As we know that to reproduce is one of a human right and infertility is contemplated as a health disease condition, we discussed of how the Assisted Reproductive Technique clinics can manage with the present pandemic circumstances and what specific instructions are to be followed by them to minimize the risk by the SARS-CoV-2 virus. Numerous countries have acted variably with diversified reactions and varying resources. It has been proposed that the reproductive health section has been receptive towards the health of its public and with the discrete patient concerns.
Impact of COVID-19 on assisted reproductive technologies and its multifacet influence on global bioeconomy
Authors: Olaniyan Olugbemi Tope , Adetunji Charles O. , Okotie Gloria E. , Adeyomoye Olorunsola , Anani Osikemekha A. , Mali Pratap Chand
Published: February 2021

Several nations of the world have issued instructions such as travel restrictions, border closure, and lockdown, plus other directives proposing that non-essential care must be withdrawn including assisted reproductive services, in an attempt to identify resources to ascertain the dissemination of SARS-CoV-2. This has led to massive shortage in medical supplies, inappropriate service delivery, hike in price, decrease in staff work load, salary cut, decrease in the utilization of qualitative maternal, and reproductive health-care services thereby creating high risk on reproductive health and global bioeconomy. The search for right candidate for the management of coronavirus disease 2019 and several reproductive health challenges begins with the screening of natural products to identify novel active constituent. Moreover, there is need to pay more attention to crucial phytochemical, bioactive fractions, phytoanalysis, and phytopharmacological investigation for effective drug discovery most especially these bioresources from beneficial microorganisms, plants, and ocean deposits that could help in mitigation of SARS-CoV-2 and reproduction health challenges through chemoinformatics, informatics, synthetic biology, nanotechnology, and metabolomics hence boosting the global economy.
Is it safe to continue with gamete cryopreservation during the pandemic? A literature review
Authors: Agarwal Akash , Sen Rahul Kumar , Satya Sanketh Dhumal , Prakash Ved
Published: February 2021

Coronavirus disease 2019 is caused by a novel coronavirus known as severe acute respiratory syndrome coronavirus 2 and is proving to be an unprecedented disaster for world health. However, the virus’s pathogenic mechanisms with regard to reproductive system remain poorly understood. In addition, compounding the problem is that many cases do not appear to show any disease signs. In ART, the cryopreservation of reproductive cells and tissues represents an important aspect that might be particularly strategic and helpful in this scenario. Cryobanking, an essential service, carries the risk of cross-contamination through cryogenic medium and calls for risk mitigation strategies. This review aims to address the available literature on the safety of cryopreservation of gametes at pandemic times. Strategies for risk mitigation have been extrapolated from reports dealing with other viruses to the current global crisis. At present, critical threats are still undefined and represent potential adverse events due to the cryopreservation of infected gametes that subsequently respread the virus.
Coronavirus disease 2019 and its impact on psychosocial aspects amongst infertile couples: An overview
Authors: Singh Neeta , Patel Garima
Published: February 2021

Following the outbreak of the coronavirus pandemic, there has been an unforeseen pressure and stress to the already burdened health-care systems. This necessitated an urgent need to reallocate the health-care resources and prompted immediate suspension and postponement of non-emergent health-care services including infertility treatments. This pandemic brought additional stress to the couples seeking infertility treatment and resulted in an indefinite time lag to their treatment thereby adding to the psychological distress among this vulnerable population. The coronavirus disease 2019 (COVID-19) has also predisposed them to various psychiatric disorders by affecting their mental, reproductive, and relationship status. These included emotional disorders ranging from frustration, depression, anxiety, hopelessness, and guilt, feelings of worthlessness in life to psychiatric disorders such as generalized anxiety disorder, major depressive disorder, and dysthymic disorder. The social isolation imposed grave psychological consequences and lead to an unpredicted change in attitudes and beliefs of such infertile couples. The implication of the loss of employment has further dwelled on their financial constraints and made this population even more labile. Thus, the current time has brought forth some unique and unexpected challenges and emotional turmoil that needs due recognition and prompt professional support. Furthermore, it is high time to review our health-care policies and hence restart infertility services striking a balance between the safety of both patient and health-care professionals amidst this pandemic while helping these unfortunate couples achieve parenthood. The resumption of infertility services post-COVID-19 has challenges of its own. The clinician and the paramedical staff had to undergo specific training to adapt to the new norms of workplace while minimizing in person interactions and exposure risk.
Association of Carcinogenic Oral Habits with Oral Squamous Cell Carcinoma
Authors:   Ziauddin College of Dentistry, Ziauddin University, Karachi, Fatima Nazish , Mohiuddin Sidra , Hosein Salim , Hosein Mervyn
Published: February 2021

OBJECTIVE: To determine the association among betel nut, betel quid or smoking alone, and betel quid combined with smoking in subjects reporting with oral sub mucous fibrosis, oral submucous fibrosis with malignant transformation in to cancer and oral squamous cell carcinoma. METHODOLOGY: An analytical cross sectional, multi centric study of n = 1009 cases collected through non-probability convenience sampling. These n=1009 subjects were subdivided into four groups: group 1, who consumed areca nut only; group 2, who chewed betel quid along with areca nut; group 3, who used betel quid and smoked; and group 4, who had no chewing habits history but were smokers. These changes were further confirmed with the help of biopsy reports of the subjects with OSMFCa and OSCC. Chi square test was performed to find out association of chewing habits with the progression of disease state. Level of significance was kept at p<0.05. RESULTS: The mean age of the sample (n=1009) were 42.79±1.31 years (range: 10-70 years). Statistically significant difference was (p<0.00) found among all four groups in terms of initiation, propagation and progression of oral squamous cell carcinoma. Furthermore, statistically insignificant difference (p=0.40) was found between group 2 and group 3 as similar number of cases (OSCC) was seen among them. CONCLUSION: Current study concluded that patients who have combined habits of chewing betel quid with areca nut and betel quid with smoking were at highest risk of initiation and progression of oral cancer. However, smoking cigarettes alone was the weakest risk factor. KEYWORDS: Betel quid; Areca nut; Smoking; Oral squamous cell carcinoma, Oral submucous fibrosis HOW TO CITE: Fatima N, Mohiuddin S, Hosein S, Hosein M. Association of carcinogenic oral habits with oral squamous cell carcinoma. J Pak Dent Assoc 2021;30(1):29-33.
Analysis of Dental Practitioners Perception Towards Dental Implants
Authors:   Altamash Institute of Dental Medicine, Karachi, Ahmed Naseer , Abbasi Maria Shakoor , Mariam Quratulain , William Hanan , Iftikhar Hafsa , Badar Hamna , Irfan Adil Bin
Published: February 2021

OBJECTIVE: To investigate the dental practitioner's knowledge, attitude and practice towards dental implants. METHODOLOGY: This study was carried out from May'2019 - Oct 2019. 752 dental practitioners who were currently practicing were included in the study. A well-structured questionnaire was used for data collection. SPSS-25 was used for statistical analysis. Spearman correlation was used to find the effect of gender, knowledge and attitude. The P <0.05 was considered statistically significant. RESULTS: In this study 80.9% dental practitioners were aware of the appropriate implant material while, 57.9% had knowledge about the types. 30.3% knew about the implant surface modifications whereas 46.1% dentists were aware of possible implant placement approaches. 49.3% believed that the distance between dental implants to be 3mm and between a dental implant and natural tooth to be 1.5 mm. 76% dentists claimed that dental implants have biomechanical complications. Whereas 67.8% knew about the Branemark's theory of osseointegration. Regarding the attitude of dental practitioners, 28.9% had received implant hands on trainings while 9% felt competent to place an implant. CONCLUSION: This study describes that dental practitioners had an appropriate knowledge of each aspect of implantology. Moreover despite the fact majority felt that they are not competent enough to practice it. Thus, it is important that the curriculum, teaching standards, the materials and methods regarding dental implants need to be reviewed and more exposure of hands-on workshops is to be provided not only for the graduates but also the undergraduates during their clinical learning. KEYWORDS: Dental Implants, Dentist's opinion, Knowledge HOW TO CITE: Ahmed N, Abbasi MS, Mariam Q, William H, Iftikhar H, Badar H, Irfan AB. Analysis of dental practitioners perception towards dental implants. J Pak Dent Assoc 2021;30(1):45-49
Endodontic Management of Acute Dental Pain Among Pregnant Patients
Authors:   University of Lahore, Khan Salman Ashraf , Hassan Arooj Ul , Iqbal Zunaira , Hassan Mohammad
Published: February 2021

OBJECTIVE: The purpose of this study is to reinforce the safety of non-surgical endodontic treatment in the management of acute dental pain of pulpal origin in pregnant patients in all trimesters. METHODOLOGY: The study was conducted amongst pregnant females with acute dental pain. Pain of endodontic origin in 273 pregnant patients was managed by performing non-surgical root canal treatment. Percentages were calculated as descriptive statistics to have a comparison of preferred treatment by dentists for acute pain management during pregnancy. One Way ANOVA was used to explore the difference between treatment selection plans. RESULTS: From the total sample of 273 participants, there was no significant difference found between the selection of endodontic treatment and Trimesters (F (2,270) = .79, p=.45) same results were obtained for the analgesics prescription during pregnancy and the trimesters during pregnancy (F (2,270) = 1.41, p=.24). On the other hand, the difference between the prescription of antibiotics during 1st, 2nd and 3rd trimesters was found which was statistically significant (F (2,270) = 12.38, p> .001). Endodontic treatment was completed on 251 (91.6%) pregnant patients to relieve the acute dental pain whereas only 22 (8.4%) patients did not undergo endodontic treatment in pregnancy. Among the cases who had endodontic treatment, 75.4% of cases were dealt with in the second trimester of pregnancy. The recommendation of antibiotics was less. In the entire data, antibiotic prescription was seen in the second trimester of pregnancy, whereas, overall, antibiotic prescription was at minimal level. Analgesic prescription was found to be (44.1%) in practice among pregnant participants during the treatment. CONCLUSION: Non-Surgical Endodontic Treatment is a safe and reliable treatment option for the management of restorable teeth with acute pain of pulpal origin in pregnant patients. Dentists should not be reluctant in prompt invasive dental management in these patients if indicated. KEYWORDS: pregnancy, pain, dental treatment, endodontic treatment HOW TO CITE: Khan SA, Hassan AU, Iqbal Z, Hassan M. Endodontic management of acute dental pain among pregnant patients. J Pak Dent Assoc 2021;30(1):7-11.
Identification of Bioisosteric Scaffolds using Scaffold Keys
Authors: Ertl Peter
Published: February 2021

Replacement of a central scaffold in a bioactive molecule by another scaffold with similar structural features (a procedure called sometimes "scaffold hopping") is a classical medicinal chemistry technique used to improve molecular properties and explore novel interesting areas of chemical space. The new scaffolds may be identified by database mining, match in physicochemical properties and often just by applying medicinal chemistry knowledge. In this study a novel method to find bioisosteric scaffolds is described when these are identified using similarity in simple substructure features called Scaffold Keys. Performance of the method is illustrated on several examples and a freely-available web tool https://bit.ly/scaffoldkeys allowing to find bioisosteric scaffold analogs is introduced.
Combined Metabolic and Chemical (CoMetChem) Labeling Using Stable Isotopes – a Strategy to Reveal Site-Specific Histone Acetylation and Deacetylation Rates by LC-MS
Authors: van Pijkeren Alienke , Dietze Jörn , Sánchez Brotons Alejandro , Lijster Tim , Barcaru Andrei , Egger Anna-Sophia , Hotze Madlen , Dekker Frank J. , Horvatovich Peter , Melgert Barbro , Ziegler Mathias , Thedieck Kathrin , Heiland Ines , Bischoff Rainer , Kwiatkowski Marcel
Published: February 2021

Histone acetylation is an important, reversible post-translational protein modification and a hallmark of epigenetic regulation. However, little is known about the dynamics of this process, due to the lack of analytical methods that can capture site-specific acetylation and deacetylation reactions. We present a new approach that combines metabolic and chemical labeling (CoMetChem) using uniformly 13C-labeled glucose and stable isotope labeled acetic anhydride. Thereby, chemically equivalent, fully acetylated histone species are generated enabling accurate relative quantification of site-specific lysine acetylation in tryptic peptides using high-resolution mass spectrometry. We show that CoMetChem enables site-specific quantification of the incorporation or loss of lysine acetylation over time, allowing the determination of reaction rates for acetylation and deacetylation. Thus, the CoMetChem methodology provides a comprehensive description of site-specific acetylation dynamics.
Mechanistic Investigations Towards a Successful PET with Breslow-Intermediates
Authors: Phan Jenny , Rehbein Julia
Published: February 2021

Experimental mechanistic studies to learn about suitable conditions for a successful photocatalytic oxidation of Breslow intermediates.Key findings a) address the effect of additives (oxidative, reductive) and assembly effects on PET and the dark reaction, b) include the experimental support of a SET + HAT sequence directly connecting the primary adduct of aldhyde and NHC and the Breslow intermediate.
Assembly and Application of a Low Budget Photo Reactor
Authors: Wallner Olov , Mamonov Kirill , Ortis Florian , Michel Dana , Michel Maurice
Published: February 2021

Photochemistry is a fast growing research field and many transformations previously not accessible to chemists now have become part of an ever growing standard repertoire. The limiting factors for a photo reactor system however is the possibility to perform stirring, removal of excess heat and the irradiation with UV or visible light – all that within a secure surrounding. Systems for starters may be as expensive as several thousand Euro. Here we design and assemble a LED photo reactor using scrap and standard materials, only spending less than 30 € for a LED. The system may be adjusted to any required wave length and its assembly is shown for the use of a 400 nm wave length lamp. To demonstrate its application, we then exemplarily use the reactor in the removal of a photo labile protection group during the synthesis of a SARS-CoV-2 spike protein glyco peptide.
High-Throughput Screening and Rational Design to Drive Discovery in Molecular Water Oxidation Catalysis
Authors: Craig Michael , Garcia-Melchor Max
Published: February 2021

In this work we study a library of 444 hypothetical complexes for the OER composed of distinct metals (Cr, Mn, Fe, Ru, Co & Ni) and ligand skeletons. These were analysed using density functional theory via different functionals to drive interesting insights and suggestions for future research of this reaction.
Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis
Authors: Pal Arun , Kretner Benedikt , Abo-Rady Masin , Glaβ Hannes , Dash Banaja P , Naumann Marcel , Japtok Julia , Kreiter Nicole , Dhingra Ashutosh , Heutink Peter , Böckers Tobias M , Günther René , Sterneckert Jared , Hermann Andreas
Published: February 2021

Intronic hexanucleotide repeat expansions (HREs) in C9ORF72 are the most frequent genetic cause of amyotrophic lateral sclerosis, a devastating, incurable motoneuron (MN) disease. The mechanism by which HREs trigger pathogenesis remains elusive. The discovery of repeat-associated non-ATG (RAN) translation of dipeptide repeat proteins (DPRs) from HREs along with reduced exonic C9ORF72 expression suggests gain of toxic functions (GOFs) through DPRs versus loss of C9ORF72 functions (LOFs). Through multiparametric high-content (HC) live profiling in spinal MNs from induced pluripotent stem cells and comparison to mutant FUS and TDP43, we show that HRE C9ORF72 caused a distinct, later spatiotemporal appearance of mainly proximal axonal organelle motility deficits concomitant to augmented DNA double-strand breaks (DSBs), RNA foci, DPRs, and apoptosis. We show that both GOFs and LOFs were necessary to yield the overall C9ORF72 pathology. Increased RNA foci and DPRs concurred with onset of axon trafficking defects, DSBs, and cell death, although DSB induction itself did not phenocopy C9ORF72 mutants. Interestingly, the majority of LOF-specific DEGs were shared with HRE-mediated GOF DEGs. Finally, C9ORF72 LOF was sufficient—albeit to a smaller extent—to induce premature distal axonal trafficking deficits and increased DSBs.
Dopplerfluxometria das artérias intra-renais em cutias (Dasyprocta prymnolopha, Wagler 1831)
Authors: Carreiro Artur da Nóbrega , Silva Edijanio Galdino , Falcão Brunna Muniz Rodrigues , Souza Joyce Galvão , Diniz João Augusto Rodrigues Alves , Araújo Débora Vitória Fernandes , Muniz Marta Silva , Alfaro Carlos Enrique Peña , Menezes Danilo José Ayres
Published: February 2021

A técnica de dopplerfluxometria é importante para aferir a hemodinâmica renal, auxiliando no diagnóstico e prognóstico de problemas renais, todavia estudos com animais silvestres ainda são escassos. Assim sendo, é de extrema importância o desenvolvimento de estudos com o intuito de estabelecer valores de referências normais nas diferentes espécies, uma vez que esses dados servirão como base para a compreensão da anatomia e fisiologia, bem como, diagnóstico de doenças na clínica veterinária. Neste sentido, este trabalho teve como objetivo obter dados dos aspectos ultrassonográficos renais normais em cutias (Dasyprocta prymnolopha, Wagler 1831). Para avaliação da morfometria ultrassonográfica utilizou-se oito cutias, nas quais foram avaliados o comprimento e largura dos rins direito e esquerdo. Para avaliação da dopplerfluxometria foram utilizadas 11 cutias, sendo analisadas as velocidades do pico sistólico máximo (VPS) e diastólico final (VDF) do fluxo sanguíneo (cm/s) e do índice de resistividade (IR) das artérias arqueadas dos rins direito e esquerdo. Os valores médios do comprimento e largura em centímetros do rim direito e esquerdo variaram entre 3,05 ± 0,13 a 1,84 ± 0,12 e 3,04 ± 0,19 a 1,91 ± 0,10, respectivamente. O valor médio observado para o índice de resistividade na artéria arqueada dos rins direito e esquerdo foram 0,41 ± 0,06 e 0,39 ± 0,05 cm/s, respectivamente. O índice de resistividade foi inferior aos observados em outras espécies de animais domésticos e até mesmo de humanos.
Cistolitectomia para tratamento de cistolitíase em coelho doméstico (Oryctolagus cuniculus): relato de caso
Authors: Guimarães Claudio Douglas Oliveira , Pantoja André Rebelo , Silva Aline Lobão da , Dias Dandara Vitoria Alves , Faria Bianca Mendonça , David Maridelzira Betânia Moraes , Moreira Luiz Fernando Moraes
Published: February 2021

A formação de urólitos em coelhos domésticos (Oryctolagus cuniculus) é uma ocorrência comum na Medicina Veterinária de Lagomorfos, em parte favorecida pela elevada concentração de cristais na composição da urina associada a uma dieta rica em minerais e pouca ingestão hídrica. Este trabalho tem como objetivo relatar um caso de cálculo vesical nesta espécie enfatizando terapia clínica e cirúrgica do caso. Foi atendido no Hospital Veterinário da Universidade Federal Rural da Amazônia um coelho doméstico tendo como principais queixas a presença de sangue na urina, perda progressiva de apetite e interesse hídrico. Durante o exame clínico foi observada presença de estrutura firme em região abdominal, a qual, após realização de exames de imagem, foi identificada como sendo um cálculo vesical. A partir disso, foi realizado tratamento clínico e cistolitectomia para retirada do urólito, seguida de adequação da dieta. O manejo clínico-cirúrgico adotado neste caso mostrou-se eficaz para a boa recuperação do paciente.
Efeitos da semente de sucupira-branca (Pterodon emarginatus, Vogel) sobre a inflamação na articulação coxofemoral em cães avaliados pela termografia
Authors: Fukahori Fernanda Lúcia Passos , Rêgo Michelle Suassuna de Azevedo , Silva Vanessa Carla Lima , Souza Daniela Maria Bastos , Jimenez George Chaves , Lima Evilda Rodrigues de
Published: February 2021

Objetivou-se verificar o efeito anti-inflamatório na articulação coxofemoral em cães, do extrato da semente de sucupira-branca utilizando como veículo o Biotônico Fontoura®. Obteve-se o extrato por meio da associação com o Biotônico Fontoura®, que permaneceu sob maceração por sete dias em refrigeração a 4°C, sendo posteriormente filtrado e acondicionado em frasco âmbar, fechado, devidamente identificado. Obteve-se o Meloxicam no comércio local. Após a anamnese, os exames complementares e a avaliação termográfica, 23 animais que se encaixavam nos pré-requisitos receberam todas as instruções. Os animais do grupo fito receberam um frasco com o extrato, para ser administrado 2,5 mL na dose e 300 mg/kg, via oral, diariamente pela manhã, por 21 dias; os do grupo alopático receberam 21 comprimidos de Meloxicam, para ser administrado conforme o fabricante. Os animais foram acompanhados pela termografia nos tempos T=0 dias, T=10 dias e T=21 dias, sendo avaliados hematológica e radiograficamente no início e no fim da pesquisa. Animais do grupo fito apresentaram efeito positivo do extrato na resolução do processo inflamatório da articulação, sendo 61% mais eficaz do que o grupo Meloxicam. Não houve alterações nos parâmetros hematológicos, bioquímicos e radiográficos.
La fotografía, medio para rescatar el valor cultural en los territorios golpeados por el conflicto
Authors: Gómez Mora Héctor Mauricio , Loaiza Soto Arley , López Rueda Blanca Aracely
Published: February 2021

El artículo expone la experiencia de investigación-acción y educomunicación en el corregimiento de El Llanito, adscrito al municipio de Barrancabermeja, en el nororiente de Colombia, donde el uso de la fotografía entre jóvenes y adolescentes locales activa la memoria colectiva y estimula el diálogo afirmativo alrededor de la propia identidad, con lo que se busca restaurar la solidaridad y, así, consolidar la capacidad de resistencia de las nuevas generaciones frente a una violencia histórica e irregular, persistente y al servicio de la instauración de un emergente orden productivo adverso a las formas de economía tradicionales en el territorio.
Reflexividad, interseccionalidad y decolonialidad en las películas etnográficas del colectivo Pasolini en Medellín sobre la diáspora negra
Authors: Pérez Quintero Camilo Ernesto , Tapias Hernández César Augusto
Published: February 2021

Este artículo explora el archivo del Colectivo Pasolini en Medellín, PemEste artículo explora el archivo del Colectivo Pasolini en Medellín, Pem―artífice de procesos colaborativos de investigación y creación concomunidades marginales―, sobre la diáspora negra y expone cómolas violencias reconstruidas en estas ficciones etnográficas pueden visibilizarse y analizarse de forma interseccional para ver lo inescin-dible de distintas formas de opresión. Si bien estas películas operan como dispositivos de empoderamiento y emancipación a través de las cuales los participantes logran objetivar las violencias a las que resis-ten, esta cualidad se potencia en escenarios de exhibición donde los análisis discursivos permiten a los receptores continuar la tarea dedescolonizar la vida diaria y el pensamiento.
The Relationship of Athlete Factors and Patient Reported Outcomes on Return To Play 1-Year Post-Anterior Cruciate Ligament Reconstruction
Authors: Balaghi Liana , King Enda , Tetreault Lindsay , Falvey Eanna
Published: February 2021

Introduction: Anterior cruciate ligament (ACL) tears are the most frequently reported knee injury in athletes. For those who wish to return to play (RTP), ACL reconstruction (ACLR) is recommended to restore knee function and stability. Knowledge of important predictors of RTP post-ACLR can aid surgeons and allied health professionals to effectively manage athletes’ rehabilitation expectations. The purpose of this study was to determine which athlete factors and patient reported outcomes predict RTP at 1-year post-ACLR.
Methods: This prospective cohort study recruited 336 participants who underwent ACLR at SSC in Dublin. Data collected included; baseline demographics, details of sport participation, injury mechanism, intent to RTP and patient-reported outcome measure (PROM) questionnaires at baseline (Marx, ACL-RSI) and at 1-year post-ACLR (Marx, ACL-RSI, Cincinnati, IKDC). Participants were categorised based on successful RTP 1-year post-ACLR. Univariate and multivariate logistic regression analysis were used to evaluate the association between RTP and athlete factors and PROMs.
Results: Two hundred twenty (65.45%) participants RTP at 1-year post-ACLR. Participants were more likely to RTP if they were younger (OR:0.972, 95%CI:0.952-0.995), intended to return to a higher level of sport (OR:2.125, 95%CI:1.169-3.861), had higher baseline Marx scores (OR: 1.066, 95%CI:1.022-1.111), and higher Marx (OR:1.291, 95%CI:1.214-1.373) and IKDC scores at 1-year post-operative (OR:1.065, 95%CI:1.041-1.088). Higher Marx scores at 1-year post-operative (OR:1.291, 95%CI:1.214-1.373) were the only significant predictors of RTP. The model yielded an area under the curve of 0.81, demonstrating excellent discriminative ability.
Discussion: Patients were more likely to RTP if they had better functional activity outcomes at 1-year post-ACLR, suggesting that PROMs can be used to assess how likely an athlete is to RTP.
Conclusion: Further research should focus on identifying which PROMs are modifiable and can be improved during post-ACLR rehabilitation to further encourage RTP.