bluuebunny/crossref_metadata_2025 huggingface dataset:
Preliminary Investigation of Teachers’ Emotional Exhaustion, Teaching Efficacy, Hope, and Colleague Support during the COVID-19 Pandemic
Authors: Bryce Crystal I. , McLean Leigh , Granger Kristen L. , Espinoza Paul , Fraser Ashley M.
Published: October 2022

The COVID-19 pandemic required teachers to quickly adapt to changes in teaching likely impacting teachers’ emotional exhaustion and feelings of teaching efficacy. Further, teachers’ experience in the classroom may have shaped how they responded to the crisis and changes. Although teachers faced these unprecedented shifts, it is possible that both internal (i.e., hope) and external (i.e., social support) sources of support may act as promotive factors for teacher outcomes. The present study describes how teachers’ emotional exhaustion, teaching self-efficacy, and supports (hope and colleague) were associated with one another one year into the pandemic. Associations were compared across early-/mid-career and veteran teachers. Results showed higher emotional exhaustion and lower hope for early-/mid-career teachers compared to veteran teachers, and a negative relation between emotional exhaustion and hope for early-/mid-career teachers. Pre-pandemic emotional exhaustion predicted hope during the pandemic for all teachers. Implications include supporting teacher well-being and career longevity considering acute stress.
Proton Exchange Membrane Fuel Cell (PEMFC) and Its Prospect for Powering Automobile in the Future
Authors: Nashira Alimatun , Asyifa Soniya Nur , Yosida Riski Sindi
Published: October 2022

Increasing responsibility toward the environment forced the transportation sector to shift its gear toward the electric vehicle. While battery electric vehicle (BEV) have started enjoying success, it poses a question as to whether or not fuel cell vehicle (FCV) becomes redundant even before being widely deployed. The commercialization of FCV usually only comes after a long period after the prototype was introduced, signifying certain barriers to large-scale utilization. Aside from the various LCAs, studies have also tried to estimate the future cost and model FCV adoption. Due to the limited data and different regional conditions in which the project was done, these researches used vastly different scenarios and assumptions, making the result differ significantly. The lack of a clear-cut answer might indicate that the fate of FCV is not yet decided, and the PEMFC might still play a part in the green transportation era, albeit not as the dominant technology. Alternative uses and the condition required to utilize them were discussed in this short review
Leveraging the Sustainable Development Goals as a boundary object in the City of Bristol
Authors: Burger Katharina , Parker Martin
Published: October 2022

This study examines how the Sustainable Development Goals (SDGs) can be leveraged to facilitate strategic change towards sustainability involving multiple stakeholders in a pluralistic city environment. By drawing on an exemplary case study of the localisation of the SDGs in Bristol, a medium-sized UK city, we show how the goals can operate as a boundary object. In particular, we identify a pattern in which the discursive localisation of the SDGs moved from problematisation and visioning through strategising and structuring towards embedding and performing. In addition, we elaborate on the three tensions that the SDGs help participants to understand and use productively, that is, across scale, time and different ways of valuing. Our study contributes to research on strategic change in pluralistic settings, such as cities, by offering a nuanced account of the discursive use of the SDGs by organisations involved in a city’s sustainable development. Furthermore, by proposing a framework based on the specific tensions that play an important role in the discursive localisation, our study advances research on the role of city strategising and practice more generally.
More than a metaphor: ‘climate colonialism’ in perspective
Authors: Bhambra Gurminder K. , Newell Peter
Published: October 2022

In early 2022, over 30 years after the Intergovernmental Panel on Climate Change (IPCC) released its first report on the challenges posed by climate change and four subsequent Assessment Reports later, the word ‘colonialism’ finally entered its official lexicon. The sixth report on ‘Impacts, Adaptation and Vulnerability’  references colonialism, not only as a historical driver of the climate crisis, but also as something that continues to exacerbate the vulnerabilities of communities to it (IPCC, 2022). As Funes (2022) argues, this comes in the wake of long-standing arguments made by Indigenous groups and others on the frontline of climate change about the centrality of colonialism to comprehending and responding to the crisis. The last decade has also seen a significant increase in scholarly literature that draws explicit links between colonialism and climate change – much of which is referenced in the latest IPCC report. While formal acknowledgement of this relationship is long overdue, in this article we argue for caution and precision in the invocation of colonialism within these debates. Following Tuck and Yang’s (2012) classic article setting out why ‘decolonization is not a metaphor’, we argue relatedly that colonialism needs to be understood as more than a metaphor in climate change debates.
Al2O3-YAG:Ce/YAG composite ceramic phosphor in a transmissive configuration for high-brightness laser-driven lighting
Authors: Sang Pengfei , Zhang Le , Kang Jian , Li Yanbin , Chen Shiwei , Yang Peng , Sun Bingheng , Li Yang , Chen Hao
Published: October 2022

High-power, high-brightness laser lighting promotes new requirements for light-conversion materials, such as high thermal conductivity, high saturation threshold and compact encapsulation. In this paper, we designed and fabricated a novel composite structure ceramic including a 1.0 × 1.0 mm2 Al2O3-YAG:Ce ceramic and a φ=16.0 mm transparent YAG ceramic for the transmissive configuration in laser lighting. When pumped by blue laser from 0∼60 W mm2, all the samples exhibited no luminous saturation phenomenon, and the 10.0 wt.%Al2O3-YAG:Ce/YAG composite ceramic with the thickness of 0.3 mm maintained white light with a luminous efficacy over 200 lm/W. Moreover, a maximal luminous flux over 1000 lm, a correlated color temperature (CCT) of 5471 K, and an operating temperature as low as 92.3 °C were obtained under the excitation power density as high as 60 W/mm2. The configuration that Al2O3-YAG:Ce encapsulated by YAG reflects an excellent optical and thermal properties by using transparent and highly thermally conductive YAG materials. These results indicate that Al2O3-YAG:Ce/ YAG composite ceramic phosphor is a promising candidate in transmissive configuration for automotive lighting and laser searchlight.
Generation of multi-OAM beams using a compact dual-mode source and a 3D-printed Luneburg lens
Authors: Cao Yuanxi , Yan Sen , Liu Wendong , Li Jianxing
Published: October 2022

In this paper, a Luneburg lens-based multi-beam orbital angular momentum (OAM) antenna is proposed to achieve the 2D beam scanning capability of dual-mode OAM beams. The proposed design is composed of nine compact dual-mode antennas as sources, and a 3D-printed Luneburg lens. The sources, i.e., octagonal patch antennas, can radiate both right-handed circularly polarized (RHCP) and left-handed circularly polarized (LHCP) OAM beams with mode number l = ±1 by switching the input ports. Then, the sources are put at multiple focal points of the Luneburg lens to generate the OAM beams in different directions, and the directivities of the OAM beams are also enhanced by the Luneburg lens. The proposed design can realize nine dual-mode OAM beams with ±30° beam scanning range in two orthogonal planes. It should be noted that the proposed design can be expanded to achieve a larger number of beams with a periodic extension of the source antennas, also a wider beam scanning range with a Luneburg lens of a larger radius.
Pinhole shifting for reducing speckle contrast in reflectance confocal microscopy
Authors: Fridman Lidan , Yelin Dvir
Published: October 2022

The high speckle contrast in reflectance confocal microscopy is perhaps the most limiting factor on this imaging modality, particularly in high scattering samples such as biological tissues. In this Letter, we propose and numerically analyze a method for speckle reduction that uses simple lateral shifting of the confocal pinhole in several directions, which results in reduced speckle contrast and only a moderate penalty in both lateral and axial resolutions. By simulating free-space electromagnetic wave propagation through a high-numerical-aperture (NA) confocal imaging system, and assuming only single-scattering events, we characterize the 3D point-spread function (PSF) that results from full-aperture pinhole shifting. Simple summation of four different pinhole-shifted images resulted in a 36% reduction in speckle contrast, with reductions of only 17% and 60% in the lateral and axial resolutions, respectively. This method could be particularly useful in noninvasive microscopy for clinical diagnosis, where fluorescence labeling is impractical and high image quality is imperative for achieving accurate diagnosis.
Physiologic signatures within six hours of hospitalization identify acute illness phenotypes
Authors: Ren Yuanfang , Loftus Tyler J. , Li Yanjun , Guan Ziyuan , Ruppert Matthew M. , Datta Shounak , Upchurch Gilbert R. , Tighe Patrick J. , Rashidi Parisa , Shickel Benjamin , Ozrazgat-Baslanti Tezcan , Bihorac Azra
Published: October 2022

During the early stages of hospital admission, clinicians use limited information to make decisions as patient acuity evolves. We hypothesized that clustering analysis of vital signs measured within six hours of hospital admission would reveal distinct patient phenotypes with unique pathophysiological signatures and clinical outcomes. We created a longitudinal electronic health record dataset for 75,762 adult patient admissions to a tertiary care center in 2014–2016 lasting six hours or longer. Physiotypes were derived via unsupervised machine learning in a training cohort of 41,502 patients applying consensus k-means clustering to six vital signs measured within six hours of admission. Reproducibility and correlation with clinical biomarkers and outcomes were assessed in validation cohort of 17,415 patients and testing cohort of 16,845 patients. Training, validation, and testing cohorts had similar age (54–55 years) and sex (55% female), distributions. There were four distinct clusters. Physiotype A had physiologic signals consistent with early vasoplegia, hypothermia, and low-grade inflammation and favorable short-and long-term clinical outcomes despite early, severe illness. Physiotype B exhibited early tachycardia, tachypnea, and hypoxemia followed by the highest incidence of prolonged respiratory insufficiency, sepsis, acute kidney injury, and short- and long-term mortality. Physiotype C had minimal early physiological derangement and favorable clinical outcomes. Physiotype D had the greatest prevalence of chronic cardiovascular and kidney disease, presented with severely elevated blood pressure, and had good short-term outcomes but suffered increased 3-year mortality. Comparing sequential organ failure assessment (SOFA) scores across physiotypes demonstrated that clustering did not simply recapitulate previously established acuity assessments. In a heterogeneous cohort of hospitalized patients, unsupervised machine learning techniques applied to routine, early vital sign data identified physiotypes with unique disease categories and distinct clinical outcomes. This approach has the potential to augment understanding of pathophysiology by distilling thousands of disease states into a few physiological signatures.
‘You don’t have to sleep with a man to get how to survive’: Girl’s perceptions of an intervention study aimed at improving sexual and reproductive health and schooling outcomes
Authors: Mason Linda , Zulaika Garazi , van Eijk Anna Maria , Fwaya Eunice , Obor David , Phillips-Howard Penelope , Nyothach Elizabeth
Published: October 2022

In sub-Saharan Africa, girls suffer from high rates of morbidity and mortality, enduring high exposure to sexual and reproductive health harms. Staying in school helps protect girls from such harms. Focus group discussions were conducted in a rural, impoverished area of Kenya with adolescent girls participating in a 4-arm cluster randomised controlled trial, evaluating menstrual cups, cash transfer, or combined cups plus cash transfer against controls. To explore girls’ perceptions of how trial interventions affected their SRH risks and schooling, semi-structured discussions were held at baseline, midline, and study end. Data was explored using thematic analysis. At baseline there were no discernible differences between the 4 intervention groups regarding their perceptions of relationships with boys/men, and difficulties attending or remaining in school. Midline and endline discussions found that narratives from those receiving cash transfer only, or alongside a cup were similar; girls noted fewer pregnancies and less school dropout, attributed to the cash transfer reducing the need for transactional sex. Lower absenteeism was reported by the cup only group, with perceived minimal effect on pregnancy and dropout. Girls in control and cup only groups described feeling valued through inclusion, benefitting from puberty and hygiene education. Although seemingly having little effect on reducing pregnancy or dropout, these inputs reportedly empowered girls, whilst cash transfer girls were emboldened to refuse male sexual advances. Girls noticed benefits from trial interventions, with a reduction in transactional sex and resulting pregnancy impacting on school dropout, or reduced menstrual related absenteeism. Education and study inclusion were perceived as important. Future programmes should consider alleviating material deprivation which prevents girls from attending or performing at school through schemes such as cash transfer, alongside hygiene and education packages. This will empower girls to refuse unwanted sex and understand risks, in addition to motivating academic achievement and school completion.

Trial registration: ClinicalTrials.gov NCT03051789.
The economic burden of low back pain in KwaZulu-Natal, South Africa: A prevalence-based cost-of-illness analysis from the healthcare provider’s perspective
Authors: Kahere Morris , Ngcamphalala Cebisile , Östensson Ellinor , Ginindza Themba
Published: October 2022

Background

Low back pain (LBP) is a multifactorial and the most prevalent musculoskeletal disorder, whose economic burden is of global concern. Evidence suggests that the burden of LBP in increasing and will continue rising with the greatest burden occurring in low-and-middle-income-countries (LMICs). This study sought to determine the economic burden of LBP in KwaZulu-Natal, South Africa from the providers perspective.

Methods

We used a retrospective prevalence-based cost-of-illness methodology to estimate the direct medical cost of LBP. Direct medical costs constituted costs associated with healthcare utilisation in inpatient care, outpatient care, investigations, consultations, and cost of auxiliary devices. We used diagnostic-specific data obtained from hospital clinical reports. All identifiable direct medical costs were estimated using a top-down approach for costs associated with healthcare and a bottom-up approach for costs associated with inpatient and outpatient care.

Results

The prevalence of chronic low back pain CLBP was 24.3% (95% CI: 23.5–25.1). The total annual average direct medical costs associated with LBP was US$5.4 million. Acute low back pain (ALBP) and CLBP contributed 17% (US$0.92 million) and 83% (US$4.48 million) of the total cost, respectively. The per patient total annual average direct medical cost for ALBP and CLBP were US$99.43 and US$1,516.67, respectively. The outpatient care costs contributed the largest share (38.9%, US$2.10 million) of the total annual average direct medical cost, 54.9% (US$1.15 million) of which was attributed to nonsteroidal-anti-inflammatory drugs (NSAIDs). The total average cost of diagnostic investigations was estimated at US$831,595.40, which formed 15.4% of the average total cost.

Conclusion

The economic burden of LBP is high in South Africa. Majority of costs were attributed to CLBP. The outpatient care costs contributed the largest share percent of the total cost. Pain medication was the main intervention strategy, contributing more than half of the total outpatient costs. Measures should be taken to ensure guideline adherence. Focus should also be placed towards development of prevention measures to minimise the cost.
Assessment of the hypervascularized fraction of glioblastomas using a volume analysis of dynamic susceptibility contrast-enhanced MRI may help to identify pseudoprogression
Authors: Roques Margaux , Catalaa Isabelle , Raveneau Magali , Attal Justine , Siegfried Aurore , Darcourt Jean , Cognard Christophe , de Champfleur Nicolas Menjot , Bonneville Fabrice
Published: October 2022

Purpose

Although perfusion magnetic resonance imaging (MRI) is widely used to identify pseudoprogression, this advanced technique lacks clinical reliability. Our aim was to develop a parameter assessing the hypervascularized fraction of glioblastomas based on volume analysis of dynamic susceptibility contrast-enhanced MRI and evaluate its performance in the diagnosis of pseudoprogression.

Methods

Patients with primary glioblastoma showing lesion progression on the first follow-up MRI after chemoradiotherapy were enrolled retrospectively. On both initial and first follow-up MRIs, the leakage-corrected cerebral blood volume (CBV) maps were post-processed using the conventional hot-spot method and a volume method, after manual segmentation of the contrast-enhanced delineated lesion. The maximum CBV (rCBVmax) was calculated with both methods. Secondly, the threshold of 2 was applied to the CBV values contained in the entire segmented volume, defining our new parameter: %rCBV>2. The probability of pseudoprogression based on rCBVmax and %rCBV>2 was calculated in logistic regression models and diagnostic performance assessed by receiving operator characteristic curves.

Results

Out of 25 patients, 11 (44%) were classified with pseudoprogression and 14 (56%) with true progression based on the Response Assessement in Neuro-Oncology criteria. rCBVmax was lower for pseudoprogression (3.4 vs. 7.6; p = 0.033) on early follow-up MRI. %rCBV>2, was lower for pseudoprogression on both initial (57.5% vs. 71.3%; p = 0.033) and early follow-up MRIs (22.1% vs. 51.8%; p = 0.0006). On early follow-up MRI, %rCBV>2 had the largest area under the curve for the diagnosis of pseudoprogression: 0.909 [0.725–0.986].

Conclusion

The fraction of hypervascularization of glioblastomas as assessed by %rCBV>2 was lower in tumours that subsequently developed pseudoprogression both on the initial and early follow-up MRIs. This fractional parameter may help identify pseudoprogression with greater accuracy than rCBVmax.
Breaking institutional barriers to enhance women’s participation in and benefit from the Peste des Petits Ruminants and Newcastle Disease vaccine value chains for Sembabule district of Uganda
Authors: Bikaako Winnie , Kabahango Patricia , Mugabi Kenneth , Yawe Agnes , Stallon Kisembo , Kyewalabye Elizabeth , Tukahirwa Lillian , Kusiimakwe Dean , Stanley Meghan , Miller Beth , Mugisha Anthony , Rosenbaum Marieke H. , Amuguni Hellen
Published: October 2022

This paper describes the institutional context that shapes the visibility and positioning of women along the Peste des Petits Ruminants (PPR) and Newcastle Disease (ND) vaccine value chains for Sembabule district of Uganda. It examines the institutional barriers and opportunities that affect women’s empowerment derived from inclusion of women in the decision-making processes along the livestock vaccine value chain (LVVC) and that can support viable women-centered and owned enterprises, at the vaccine development, delivery, distribution and use level. Qualitative data analysis tools such as focus group discussions, focus meals, jar voices and key informant interviews were used. Using outcome mapping, a stakeholder analysis of the critical partners in the PPR and ND value chain was done involving the regulators, vaccine manufacturers, importers, distributors, agrovets, public and private veterinary service deliverers, local leaders, women groups, and farmers. The study concluded that training related to gender equality and livestock vaccines, infrastructural and technical support to the poultry and goat women and men farmers and other chain actors are inadequate in themselves to increase vaccine adoption and improve livestock productivity in Sembabule district. Strategies that promote gender-transformative collaborative efforts among the LVVC actors and build viable gender-transformed women groups and networks are critical to increase women’s participation in and benefit from the livestock vaccine value chain.
Monitoring and early warning of a metal mine tailings pond based on a deep learning bidirectional recurrent long and short memory network
Authors: Jing Zhanjie , Gao Xiaohong
Published: October 2022

The effective monitoring and early warning capability of metal mine tailings ponds can improve the associated safety risk management level. The infiltration line is an important core index of tailings pond stability. In this paper, a tailings pond monitoring and early warning system, which provides technical support for the design and daily management of tailings reservoir early warning systems, is constructed. Based on a deep learning bidirectional recurrent long and short memory network, an infiltration line prediction model with univariate input and an infiltration line prediction model with multivariate input are proposed. The data adopted are those from four monitoring points of the same cross-section at different positions and data from one adjacent internal lateral displacement and internal vertical displacement monitoring point. Using the adaptive moment estimation (Adam) optimization algorithm and the root mean square error (RMSE) model evaluation metric, the multilayer perceptron model, univariate input model, and multivariate input model are compared. This work shows that their RMSEs are 0.10611, 0.09966, and 0.11955, respectively.
Analysis of antidiabetic, antiulcer and analgesic potential of traditional ethnomedicinal plant Emex spinosa (L.) Campd. from Azad Jammu and Kashmir
Authors: Ajaib Muhammad , Ishtiaq Saiqa , Ishtiaq Muhammad , Maqbool Mehwish , Bhatti Khizar Hayat , Khan Afsheen , Afreen Afeera , Hussain Tanveer , Sardar Tauqeer , Gul Alia , Azeem Muhammad
Published: October 2022

In this research antidiabetic, analgesic and antiulcer potential of traditional ethnomedicinal plant: Emex spinosa (L.) Campd. (Family Polygonaceae) was evaluated by extracting its phytoconstituents using methanol (MeOH) solvent through maceration protocol. The quantitative phytochemical analysis of the extract revealed flavonoids were highest in leaf extract (15.63±0.93 mg/mL) and with (11.5±0.57 mg/mL) in stem. Alkaloids and tanins were also present in the samples in various conc. while saponins were absent. To confirm pharmaceutical potential of plant against ulcer, diabetes and analgesic infirmities, a model experimental animal wistar albino rats (Rattus norvegicus) were used. In antiulcer study, using hot plate method the maximum results were observed with 250 mg/kg in the 2.5 hours of study. The leaf extract showed a 40.41±2.73 latency time and the fruit with a 36.77±2.41, and the stem with a 27.85±3.09, which was comparable to the standard drug Aspirin, i.e., 47.5±0.57. For analysis of antiulcer potential of the plants parts doses of 250 and 500 mg/kg was applied to check the reclamation of ethanol-induced acute ulcer and of Aspirin-induced chronic ulcer of stomach. In order to confirm efficacy of the drug potential of plant following parameters like microscopic evaluation, gastric volume, total acidity, mucosa weight, ulcer index, pH and histopathology of stomach were analyzed. In antidiabetic analysis, in an acute study after a single dose of 500 mg/kg extract after 2hrs the blood glucose levels were 367±51.09958NS, 416±59.79548NS, 437.5±61.96437NS mg/dL for leaf, stem and fruit, respectively. After4hrs 351.75±88.27644NS mg/dl, 448.25±25.64948NS mg/dl, 445.25±27.07205NS mg/dl and after 6hrs 354.5±92.70428NS, 442±24.60691NS, a440±33.16625NS mg/dl, respectively. The analgesic activity was explored by applying hot plate, tail flick and formalin paw licking method. In hot plate method the maximum results were observed with 250mg/kg in the 2.5 hours of study. The leaf extract showed a 40.41±2.73 latency time and the fruit with a 36.77±2.41 and the stem with a 27.85±3.09, which was comparable to the standard drug Aspirin, i.e., 47.5±0.57. The respective plant extracts at 250mg/kg showed a gradual rise in latency time when compared to the control. It was concluded that all three components of E. spinosa perform proved to be significant as potential source of herbal medicines to cure different prevalently occurring diseases. Furthermore, it was confirmed through results analysis that plant t can be used to discover novel drug using dedicated high throughput techniques and ethnopharmacological approaches.
Incidence and predictor of diabetic foot ulcer and its association with change in fasting blood sugar among diabetes mellitus patients at referral hospitals in Northwest Ethiopia, 2021
Authors: Abuhay Habtamu Wagnew , Yenit Melaku Kindie , Wolde Haileab Fekadu
Published: October 2022

Background

Diabetes mellitus is one of the global public health problems and fasting blood sugar is an important indicator of diabetes management. Uncontrolled diabetes can lead to diabetic foot ulcers, which is a common and disabling complication. The association between fasting blood glucose level and the incidence of diabetic foot ulcers is rarely considered, and knowing its predictors is good for clinical decision-making. Therefore, the aim of this study was to determine the incidence and predictors of diabetic foot ulcers and its association with changes in fasting blood sugar among diabetes mellitus patients at referral hospitals in Northwest Ethiopia.

Methods

A multicenter retrospective follow-up study was conducted at a referral hospital in Northwest Ethiopia. A total of 539 newly diagnosed DM patients who had follow-up from 2010 to 2020 were selected using a computer-generated simple random sampling technique. Data was entered using Epi-Data 4.6 and analyzed in R software version 4.1. A Cox proportional hazard with a linear mixed effect model was jointly modeled and 95% Cl was used to select significant variables. AIC and BIC were used for model comparison.

Result

A total of 539 diabetes patients were followed for a total of 28727.53 person-month observations. Overall, 65 (12.1%) patients developed diabetic foot ulcers with incidence rate of 2.26/1000-person month observation with a 95% CI of [1.77, 2.88]. Being rural (AHR = 2.30, 95%CI: [1.23, 4.29]), being a DM patient with Diabetic Neuropathy (AHR = 2.61, 95%CI: [1.12, 6.06]), and having peripheral arterial disease(PAD) (AHR = 2.96, 95%CI: [1.37, 6.40]) were significant predictors of DFU. The time-dependent lagged value of fasting blood sugar change was significantly associated to the incident of DFU (α = 1.85, AHR = 6.35, 95%CI [2.40, 16.79]).

Conclusion and recommendation

In this study, the incidence of DFU was higher than in previous studies and was influenced by multiple factors like rural residence, having neuropathy, and PAD were significant predictors of the incidence of DFU. In addition, longitudinal changes in fasting blood sugar were associated with an increased risk of DFU. Health professionals and DM patients should give greater attention to the identified risk factors for DFU were recommended.
Rapid label-free detection of cholangiocarcinoma from human serum using Raman spectroscopy
Authors: Suksuratin Peeraya , Rodpai Rutchanee , Luvira Vor , Intapan Pewpan M. , Maleewong Wanchai , Chuchuen Oranat
Published: October 2022

Cholangiocarcinoma (CCA) is highly prevalent in the northeastern region of Thailand. Current diagnostic methods for CCA are often expensive, time-consuming, and require medical professionals. Thus, there is a need for a simple and low-cost CCA screening method. This work developed a rapid label-free technique by Raman spectroscopy combined with the multivariate statistical methods of principal component analysis and linear discriminant analysis (PCA-LDA), aiming to analyze and classify between CCA (n = 30) and healthy (n = 30) serum specimens. The model’s classification performance was validated using k-fold cross validation (k = 5). Serum levels of cholesterol (548, 700 cm-1), tryptophan (878 cm-1), and amide III (1248,1265 cm-1) were found to be statistically significantly higher in the CCA patients, whereas serum beta-carotene (1158, 1524 cm-1) levels were significantly lower. The peak heights of these identified Raman marker bands were input into an LDA model, achieving a cross-validated diagnostic sensitivity and specificity of 71.33% and 90.00% in distinguishing the CCA from healthy specimens. The PCA-LDA technique provided a higher cross-validated sensitivity and specificity of 86.67% and 96.67%. To conclude, this work demonstrated the feasibility of using Raman spectroscopy combined with PCA-LDA as a helpful tool for cholangiocarcinoma serum-based screening.
Clinical characteristics and predictors of esophagogastric variceal bleeding among patients with HCV-induced liver cirrhosis: An observational comparative study
Authors: El Sheref Saad El Deen Mohamed , Afify Shimaa , Berengy Mahmoud S.
Published: October 2022

Objectives

To investigate the clinical characteristics, risk factors, and predictors of esophagogastric variceal bleeding in patients with hepatitis C virus (HCV)-induced liver cirrhosis.

Methods

This comparative observational study was carried out on 100 patients suffering from post hepatitis cirrhosis and portal hypertension who were admitted to the Internal Medicine Department, Al-Azhar University Hospital, Damietta Egypt. Patients were classified into two groups: 50 of them presented with esophagogastric varices with acute variceal bleeding, and 50 patients presented without bleeding. Data were collected, coded, revised, and entered into the Stata software version 16.

Results

The mean age of patients with bleeding was slightly higher than those without bleeding (55.58 ± 5.89 vs. 52.54 ± 9.01 years), p = 0.049. Mild ascites, positive H.Pylori, and Child-Pugh score B and C were an independent predictors of esophagogastric variceal bleeding (OR = 0.036, 95% CI: 0.0004–0.36; p = 0.005), (OR = 7.36, 95% CI: 1.44–37.59; p = 0.016), (OR = 19.0, 95% CI: 2.02–186.3; p = 0.010), and (OR = 40.51, 95% CI: 2.18–751.31; p = 0.013). The sensitivity of this model was 93.88%, specificity was 53.85%, PPV was 88.46%, NPV was 70.0%, correctly classified patients were 85.48%, and AUC was 90.27%. In the second model, pepsinogen level higher than 43.5 μg/l, AST (>54.5), Bilirubin (>1.45), and Hemoglobin (>11.5) were a significant independent predictors of esophagogastric variceal bleeding (OR = 1.18, 95% CI: 1.09–1.27; p<0.001), (OR = 1.14, 95% CI: 1.03–1.27; p = 0.007), (OR = 5.55, 95% CI: 1.21–25.43; p = 0.027), and (OR = 0.05, 95% CI: 0.008–0.32; p = 0.002), respectively. The sensitivity of this model was 92%, specificity was 98%, PPV was 97.87%, NPV was 92.45%, correctly classified patients were 95%, and AUC was 98.68%.

Conclusion

The independent predictors of esophagogastric variceal bleeding were ascites, positive H. pylori, Child-Pugh score B and C, pepsinogen level higher than 43.5 μg/l, AST (>54.5), bilirubin (>1.45), and hemoglobin (>11.5). Laboratory investigations are more reliable in predicting variceal bleeding and excluding non-variceal bleeding; however, clinical symptoms should not be neglected, especially H. pylori infection, ascites, and Child-Pugh score.
Geographic variation and factors associated with under-five mortality in Ethiopia. A spatial and multilevel analysis of Ethiopian mini demographic and health survey 2019
Authors: Tessema Zemenu Tadesse , Tebeje Tsion Mulat , Gebrehewet Lewi Goytom
Published: October 2022

Background

The distribution of under-five mortality (U5M) worldwide is uneven and the burden is higher in Sub-Saharan African countries, which account for more than 53% of the global under-five mortality. In Ethiopia, though U5M decreased substantially between 1990 and 2019, it remains excessively high and unevenly distributed. Therefore, this study aimed to assess geographic variation and factors associated with under-five mortality (U5M) in Ethiopia.

Methods

We sourced data from the most recent nationally representative 2019 Ethiopian Mini-Demographic and Health Survey for this study. A sample size of 5,695 total births was considered. Descriptive, analytical analysis and spatial analysis were conducted using STATA version 16. Both multilevel and spatial analyses were employed to ascertain the factors associated with U5M in Ethiopia.

Results

The U5M was 5.9% with a 95% CI 5.4% to 6.6%. Based on the multivariable multilevel logistic regression model results, the following characteristics were associated with under-five mortality: family size (AOR = 0.92, 95% CI: 0.84,0.99), number of under-five children in the family (AOR = 0.17, 95% CI: 0.14, 0.21), multiple birth (AOR = 14.4, 95% CI: 8.5, 24.3), children who were breastfed for less than 6 months (AOR = 5.04, 95% CI: 3.81, 6.67), people whose main roof is palm (AOR = 0.57, 95% CI: 0.34, 0.96), under-five children who are the sixth or more child to be born (AOR = 2.46, 95% CI: 1.49, 4.06), institutional delivery (AOR = 0.57, 95% CI: 0.41, 0.81), resident of Somali and Afar region (AOR = 3.46, 95% CI: 1.58, 7.55) and (AOR = 2.54, 95% CI: 1.10, 5.85), respectively. Spatial analysis revealed that hot spot areas of under-five mortality were located in the Dire Dawa and Somali regions.

Conclusion

Under-five mortality in Ethiopia is high and unacceptable when compared to the 2030 sustainable development target, which aims for 25 per 1000 live births. Breastfeeding for less than 6 months, twin births, institutional delivery and high-risk areas of under-five mortality (Somali and Dire Dawa) are modifiable risk factors. Therefore, maternal and community education on the advantages of breastfeeding and institutional delivery is highly recommended. Women who deliver twins should be given special attention. An effective strategy should be designed for intervention in under-five mortality hot spot areas such as Somali and Dire Dawa.
Associations of hyponatremia and SIADH with increased mortality, young age and infection parameters in patients with tuberculosis
Authors: Bal Christina , Gompelmann Daniela , Krebs Michael , Antoniewicz Lukasz , Guttmann-Ducke Claudia , Lehmann Antje , Milacek Christopher Oliver , Gysan Maximilian Robert , Wolf Peter , Jentus Maaia-Margo , Steiner Irene , Idzko Marco
Published: October 2022

Background and objective

Hyponatremia and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) are associated with and can be caused by tuberculosis (TB) through meningitis by locally invading the hypothalamus, adrenal, or pituitary glands or possibly through ectopic ADH production. This study assessed the association of TB mortality with hyponatremia and SIADH in a large cohort of a university hospital in Austria.

Methods

This retrospective study enrolled patients with hyponatremia and patients diagnosed with TB from 01/2001-11/2019 to assess the prevalence of TB in hyponatremia and TB morbidity and mortality in patients with and without hyponatremia. Sex, age, microbiological results, laboratory tests and comorbidities were analysed and used to calculate survival rates.

Results

Of 107.532 patients with hyponatremia (0.07%) and 186 patients with TB (43%), 80 patients were diagnosed with both—hyponatremia and TB. Only three TB patients had SIADH, precluding further SIADH analysis. In hyponatremia, young age and high CRP levels showed significant associations with TB diagnosis (p<0.0001). Survival rates of patients diagnosed with TB with moderate to profound hyponatremia were significantly lower than those without hyponatremia (p = 0.002).

Conclusion

In this study of a large cohort from a tertiary care hospital in a non-endemic area of TB, 0.07% of patients presenting with hyponatremia, but especially younger patients and patients with high CRP values, were diagnosed with TB. Crucially, patients with moderate to profound hyponatremia had a significantly higher mortality rate and thus required increased medical care.
A dichotomy of smokers in the Philippines following sin tax reform: Distinguishing potential quitters from those unlikely to quit
Authors: Cheng Kent Jason Go , Estrada Miguel Antonio Garcia
Published: October 2022

The Philippine government significantly raised cigarette excise taxes in 2013, following passage of the landmark Sin Tax Reform Act of 2012. As a result, cigarette prices increased substantially. Given varying smokers’ responses to the price increase, we examined underlying typologies of Filipino smokers and assessed how these typologies determine smoking intensity. We used cross-sectional data from the 2015 wave of the Philippine Global Adult Tobacco Survey (N = 1,651). To uncover typologies, random effects latent class modelling was used on six individual smoker responses (attempting to stop, thinking about quitting, decreasing sticks smoked, switching to cheaper brands, buying in bulk, and asking from others). Bivariate and multivariate analyses were employed to uncover determinants of typologies and smoking intensity. We found two typologies based on smokers’ response. The first group, called “potential quitters” (62.62%), is composed of smokers who are more likely to consider quitting and decrease sticks smoked. The second group, called “unlikely to quit” (37.38%), have smokers who opt for price-minimization strategies like switching to cheaper brands, buying in bulk, or asking cigarettes from others. Potential quitters tend to be female, a student, and less nicotine dependent. They smoke up to three fewer sticks than those unlikely to quit, controlling for other factors. Nicotine dependence stood out as the most important predictor of being in the unlikely to quit group. The dominant role of nicotine dependence in determining a smoker’s typology points to the need for non-price based measures, such as those targeted towards highly-nicotine dependent smokers, to complement tax-induced price increases and comprehensively address the smoking problem.
Automated computed tomography based parasitoid detection in mason bee rearings
Authors: Thomson Bart R. , Hagenbucher Steffen , Zboray Robert , Oesch Michelle Aimée , Aellen Robert , Richter Henning
Published: October 2022

In recent years, insect husbandry has seen an increased interest in order to supply in the production of raw materials, food, or as biological/environmental control. Unfortunately, large insect rearings are susceptible to pathogens, pests and parasitoids which can spread rapidly due to the confined nature of a rearing system. Thus, it is of interest to monitor the spread of such manifestations and the overall population size quickly and efficiently. Medical imaging techniques could be used for this purpose, as large volumes can be scanned non-invasively. Due to its 3D acquisition nature, computed tomography seems to be the most suitable for this task. This study presents an automated, computed tomography-based, counting method for bee rearings that performs comparable to identifying all Osmia cornuta cocoons manually. The proposed methodology achieves this in an average of 10 seconds per sample, compared to 90 minutes per sample for the manual count over a total of 12 samples collected around lake Zurich in 2020. Such an automated bee population evaluation tool is efficient and valuable in combating environmental influences on bee, and potentially other insect, rearings.
NSAIDs affect dendritic cell cytokine production
Authors: Raaijmakers Tonke K. , van den Bijgaart Renske J. E. , Scheffer Gert Jan , Ansems Marleen , Adema Gosse J.
Published: October 2022

Background

Immunotherapy is now considered as the new pillar in treatment of cancer patients. Dendritic cells (DCs) play an essential role in stimulating anti-tumor immune responses, as they are capable of cross-presenting exogenous tumor antigens in MHCI complexes to activate naïve CD8+ T cells. Analgesics, like non-steroid anti-inflammatory drugs (NSAIDs), are frequently given to cancer patients to help relieve pain, however little is known about their impact on DC function.

Methods

Here, we investigated the effect of the NSAIDs diclofenac, ibuprofen and celecoxib on the three key processes of DCs required for proper CD8+ cytotoxic T cell induction: antigen cross-presentation, co-stimulatory marker expression, and cytokine production.

Results

Our results show that TLR-induced pro- and anti-inflammatory cytokine excretion by human monocyte derived and murine bone-marrow derived DCs is diminished after NSAID exposure.

Conclusions

These results indicate that various NSAIDs can affect DC function and warrant further investigation into the impact of NSAIDs on DC priming of T cells and cancer immunotherapy efficacy.
Trust in social media and COVID-19 beliefs and behaviours
Authors: Nicholls Nicky , Yitbarek Eleni
Published: October 2022

The study investigates the relationship between trust in social media and beliefs and preventive behaviours in the context of the COVID-19 pandemic. We surveyed 1008 respondents in South Africa to study how trust in social media relative to other information sources predicts perceived risk and adoption of preventive behaviours. Although engagement with and trust in social media do not predict less adoption of preventive behaviours, trusting information from social media more than information from mass media or scientists is associated with less risk perception from COVID-19 and reduces the adoption of preventive behaviours (including vaccines).
The impact of COVID-19 on implementation of mass testing, treatment and tracking of malaria in rural communities in Ghana: A qualitative study
Authors: Cheng Ndong Ignatius , Tabong Philip Teg-Nefaah , Netongo Palmer Masumbe , Mensah Benedicta Ayiedu , Chu Chuo Ennestine , Yaw Effah-Baafi , Enos Juliana Yartey , Malm Keziah , Ahorlu Collins Stephen
Published: October 2022

Background

Mass test, treat and track (MTTT) of malaria is ongoing in the Pakro sub district of Ghana. In the delivery of MTTT of malaria, community health volunteers are trained to routinely provide this service through a door-to-door strategy. Following the report of the first cases of COVID-19 in Ghana, we conducted this study to explore the effects of the pandemic on the implementation of the MTTT of malaria intervention.

Methods

Using qualitative methodology, we conducted ten focus groups discussions (FGDs) in eight communities: eight with community members (N = 49); one with health workers (N = 6), and one with MTTT of malaria volunteers. In addition, two in-depth interviews (IDI) were conducted, one with health worker and another with a health manager. All interviews were recorded, translated into English during transcription and analysed using QSR NVivo 12. Thematic content analysis was used in this study.

Results

The findings of the study showed an increase in the number of people reporting with complications of malaria in health facilities in the study communities during the COVID-19 period. Some participants were of the view that COVID-19 rumours and misinformation could largely be responsible for the low coverage and uptake of the MTTT of malaria intervention. To sustain the uptake of the MTTT intervention, community engagement strategies were employed to identify and respond to these rumours. Also, incentive schemes were introduced to encourage parents and children to participate in the MTTT intervention during this period of COVID-19.

Conclusion

Findings suggest that the COVID-19 pandemic has adversely affected the provision and uptake of malaria prevention and treatment services, especially the MTTT of malaria being implemented at the community level. These observations underscore the need to find innovative ways to address the challenges encountered in providing essential services during public health emergencies.
Comparative analysis of Fenghuang Dancong, Tieguanyin, and Dahongpao teas using headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry and chemometric methods
Authors: Li Zhangwei
Published: October 2022

Fenghuang Dancong, Tieguanyin, and Dahongpao teas are belonged to semi-fermented oolong teas and are famous for their unique aroma. However, reports regarding the systematic comparison, differentiation, and classification of the volatile components of these three types of oolong teas are lacking. In this study, we aimed to establish a method for distinguishing these three types of oolong teas. The volatile components in a total of 21 tea samples of these three types of oolong teas were extracted, determined, and identified by headspace solid-phase microextraction (HS-SPME) combined with gas chromatography-mass spectrometry (GC-MS). In addition, chemometric methods such as hierarchical cluster analysis (HCA), principal component analysis (PCA), and orthogonal partial least squares discriminant analysis (OPLS-DA) were used for distinguishing and classifying the three types of oolong teas on the basis of the similarities and differences in the volatile components. The results showed that 125 volatile components were extracted and identified from the three types of oolong teas, among which 53 volatile components overlapped among the samples. The results of HCA indicated that the samples of each of the three types of oolong teas could be placed in one category when the t value was 220. The results of PCA and OPLS-DA showed that the volatile components such as dehydrolinalool, linalool oxide II, linalool, α-farnesene, linalool oxide I, β-ocimene, nerolidol, cis-3-butyric acid folate, myrcene, and (Z)-hexanoic acid-3-hexenyl ester are the characteristic components, which can be used to distinguish the three types of oolong teas. We developed a simple, fast, and efficient method for distinguishing three types of oolong teas and provided a feasible technique for the identification of oolong tea types.