bluuebunny/crossref_metadata_2025 huggingface dataset:
Sex-specific switching of responsive immune pathways in vaccinated diabetic murine model exposed to influenza infection
Authors: Sengupta Anirban , Al-Otaibi Noha , Hinkula Jorma
Published: October 2022

Seasonal influenza vaccination has different implications on the immune response depending on the comorbidities. Diabetes is one such critical disease that increases the patient’s susceptibility to influenza and suppresses vaccine efficacy and immunity. The sex of the individuals also plays a definitive role in it. This study aims to understand the efficacy of the seasonal vaccine against influenza in diabetic groups and undergoing immune mechanisms in both sexes. There is a switching of the female with diabetes towards stronger cell-mediated immunity and Th1/Th17 response with suppressed humoral immunity. They show enhanced proinflammatory activities within T cells, CD8T activation, Th17 proliferation, and the majority of IgG2 antibody subtypes with reduced neutralization potential. Males with diabetes exhibit enhanced humoral Th2-immunity than the non-diabetic group. They exhibit higher MHCII, and DEC205 levels in dendritic cells, an increase in plasma B lymphocytes, and influenza-haemagglutinin specific IgG titer with stronger virus neutralization potential. This study highlights the critical immune mechanisms and sex-specific swapping of their preferred immune response pathways against influenza after vaccination during diabetes. We propose a need for a sex-specific customized vaccine regimen to be implemented against influenza for individuals having diabetes to exploit the manifested strength and weakness in their protective immunity.
UHPLC-HRMS-Based Serum Untargeted Lipidomics: PCs and SMs are the Main disturbed lipid markers to Distinguish Colorectal Advanced Adenoma from Cancer
Authors: Zhu Yifan , Zhou Hailin , Chen Hongwei , Zhang Jiahao , Liang Yunxiao , Zhu Pingchuan , Hua Chaolei , Zhang Qisong
Published: October 2022

Background
Colorectal advanced adenoma (CAA) is a key precancerous lesion of colorectal cancer (CRC), and early diagnosis can lessen CRC morbidity and mortality. Although abnormal lipid metabolism is associated with the development of CRC, there are no studies on the biomarkers and mechanisms of lipid metabolism linked to CAA carcinogenesis. Methods: The serum lipidomics was investigated with CAA (N = 46) and CRC (N = 50) patients by ultra high-performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) in both electrospray ionization (ESI) modes. Differential lipids were selected by univariate and multivariate statistics analysis, and their diagnostic performance was evaluated using a receiver operating characteristic curve (ROC) analysis.
Results
Combining P < 0.05 and variable importance in projection (VIP) > 1, 59 differential lipids were obtained totally. Ten of them showed good discriminant ability for CAA and CRC (AUC > 0.900). Especially, the lipid panel consisting of PC 44:5, PC 35:6e, and SM d40:3 showed the highest selection frequency and outperformed (AUC = 0.952). Additionally, phosphatidylcholine (PC) and sphingomyelin (SM) were the main differential and high-performance lipids.
Conclusions
PC and SM are the main biomarker candidates to distinguish CAA from CRC, and dysregulated metabolism of them may play a key role in CAA carcinogenesis.
Tidal effect on nitrate and dissolved organic carbon concentrations in river water in the Bekanbeushi River watershed in eastern Hokkaido, northern Japan
Authors: Shibata Hideaki , Takeuchi Shota , Ding Manhui , Shiraiwa Takayuki , Katsuyama Masanori , Nakaoka Masahiro , Nakada Satoshi , Nagao Seiya
Published: October 2022

Downstream wetlands play an important role as an interface between terrestrial and coastal areas, and nutrients and dissolved organic matter in downstream rivers are recognized as important parameters for various ecosystem functions and services in the watershed ecosystem. In this study, nitrate nitrogen and dissolved organic carbon in river water were observed with high temporal resolution at 10-minute intervals using water quality sensors in the downstream wetland area of the Bekanbeushi River watershed in northern Japan. The river water flow was similarly measured to examine the relationship between water quality and riverine volume transport in downstream river water under the influence of tidal fluctuations. The tidally induced cycles of riverine volume transport (i.e., discharge (tidal ebb) and backflow (tidal flood)) had a nonnegligible effect on the concentration-flow (C-Q) relationships of nitrate nitrogen and dissolved organic carbon. Tidal saltwater upwelling was also found to disturb the C-Q relationship by increasing the nitrate-nitrogen concentrations and decreasing the dissolved organic carbon concentrations. Intense rainfall infiltration also contributed to the reduction in the concentrations of both components. The results suggest that changes in hydrologic processes due to tidal fluctuations and heavy rainfall have a nonnegligible effect on nutrient and dissolved organic matter concentrations in downstream watersheds.
GBA/GBN-position on the feedback of incidental findings in biobank-based research: consensus-based workflow development and pilot implementation
Authors: Geiger Joerg , Fuchs Jörg , Starke Madeline , Neumann Michael , Baber Ronny , Nussbeck Sara , Kiehntopf Michael , Specht Cornelia , Illig Thomas , Hummel Michael , Jahns Roland
Published: October 2022

Incidental research findings pose a considerable challenge to clinical biobanks since they are acting as intermediaries between healthcare and research. In a joint action the centralized biobank ibdw (Interdisciplinary Bank of Biomaterials and Data Wuerzburg) together with local authorities drafted a coherent concept to manage incidental research findings in full compliance with ethical and data privacy regulations. The concept was developed and elaborated in close collaboration with the German Biobank Alliance (GBA). The first implementation was piloted and evaluated in a testbed. Comprehensive documentation of all steps guarantees the traceability of the process. By a mandatory assessment of the findings prior to re-identification of the individual concerned, unnecessary measures can be avoided. The individual's right to “not to know” is respected according to the stipulations of the informed consent. As a general principle any communication with the individual occurs exclusively through the hospital and by competent physicians with appropriate knowledge and communication skills. We propose this scheme as a blueprint for reporting workflows for incidental research findings at hospital-integrated biobanks.
Performance and Protection of Pre-Engineered Buildings Subjected to Blast and Earthquake Excitations
Authors: Kangda Muhammed Zain , Sah Subhash Kumar , Bakre Sachin
Published: October 2022

Technological advancements and improvements with time have significantly contributed to improve the living standards with new kind of products and utilities. An example of such technological improvement in structural engineering is Pre-Engineered Building (PEB). This concept includes pre-designing and pre-fabrication processes. A Pre-Engineered Building (PEB) refers to a building which is pre-designed at a factory using some simulation and modelling software as per the specifications, codes and the loads that will be acting on the structure before production of the building components and then finally assembled at site thereby reducing the completion time. In the current study, a case study of an existing PEB structure subjected to wind analysis has been investigated. The main objective of the present study is to evaluate the retrofitting ability of passive control dampers in the event of an earthquake or blast phenomenon. The study shows the effectiveness of vibration control techniques in the form of passive dampers in improving the performance of PEB structure subjected to blast and earthquake using fluid viscous dampers. The study also discusses the impact of different damper placements and properties on the structural performance of PEB structure subjected to blast and earthquake. Primarily three damper placement techniques are incorporated in the present study namely single diagonal, V-shaped damper and inverted V-shaped damper. The structural performance of PEB structure has been studied using finite element tool considering the non-linear analysis and comparing the structural responses for with and without damper conditions. The V-shaped and inverted V-shaped damper placement technique is the most effective approach in resisting the damaging effects against blasts and earthquakes for the selected PEB structure in comparison to the conventional diagonal braced dampers.
Fast and Ultra-Low Energy Subthreshold Level Shifter using Split-gate Buffer for Low-power Digital VLSI Systems
Authors: SA Sivakumar , B Senthilkumar , Rajendran Selvakumar
Published: October 2022

Low-energy operation is predominant feature in the modern wireless sensor node and implantable biomedical applications. Scaling the supply voltage towards sub-/near-threshold level is vital design methodology to achieve energy-efficient operation. Voltage scaling can be adopted in the multiple supply voltage design incorporating interfacing circuit called voltage level shifters to achieve power-efficient operation. This paper presents differential cascode voltage switch (DCVS) structure based high-speed and low-energy voltage level shifter for converting subthreshold voltage to nominal output voltage. The proposed level shifter (LS) utilizes NMOS/PMOS diode pairs along with the cross-coupled PMOS to address the current contention issue by suppressing the current from pull-up network while pull-down network is activated. The switching speed of the level conversion is enhanced by pass transistor and boosting devices in the pull-down network. Further, split-gate inverter/buffer at the output stage ensures high performance by alleviating static power and accelerating speed performance. The proposed LS is implemented in CMOS 180nm technology on Cadence (Virtuoso) platform and analyzed using Spectre circuit simulator. The simulation results reveal the subthreshold level conversion from 220 mV to 1.8 V and wider frequency range of conversion. In addition, it ensures the delay of 8.57 ns, energy/transition of 39.4 fJ for level conversion from 0.4 V to 1.8 V with input signal frequency of 1 MHz. Moreover, the LS consumes static power of 0.302 nW at standby mode.
Depression, anxiety and post-traumatic stress during the Russo- Ukrainian war in 2022: A Comparison of the Populations in Poland, Ukraine and Taiwan
Authors: Chudzicka-Czupała Agata , Hapon Nadiya , Chiang Soon Kiat , Żywiołek-Szeja Marta , Karamushka Liudmyla , Lee Charlotte T. , Grabowski Damian , Paliga Mateusz , Rosenblat Joshua D. , Ho Roger , McIntyre Roger S. , Chen Yi-Lung
Published: October 2022

Background
Ukraine has been embroiled in an increasingly war since February 2022. In addition to Ukrainians, the Russo-Ukraine war has affected Poles due to the refugee crisis and the Taiwanese, who are facing a potential crisis with China. We examined the mental health status and associated factors in Ukraine, Poland and Taiwan. The data will be used for future reference as the war is still ongoing.
Methods
From March 8 to April 26, 2022, we conducted an online survey using snowball sampling techniques in Ukraine, Poland and Taiwan. Depression, anxiety and stress were measured using the Depression, Anxiety and Stress (DASS)-21 item scale; post-traumatic stress symptoms by the Impact of Event Scale-Revised (IES-R) and coping strategies by the Coping Orientation to Problems Experienced Inventory (Brief-COPE). We used univariate and multivariate linear regression to identify factors associated with DASS-21 and IES-R scores.
Results
There were 1625 participants (Poland: 1053; Ukraine: 385; Taiwan: 188) in this study. Ukrainian participants reported significantly higher DASS-21 (p < 0.001) and IES-R (p < 0.01) scores than Poles and Taiwanese. Although Taiwanese participants were not directly involved in the war, their mean IES-R scores (40.37 ± 16.86) were only slightly lower than Ukrainian participants (41.36 ± 14.94), and Taiwanese were associated with higher IES-R scores (p = 0.029) after adjustment of other variables. Taiwanese reported significantly higher avoidance score (1.60 ± 0.47) than the Polish (0.87 ± 0.53) and Ukrainian (0.91 ± 0.5) participants (p < 0.001). More than half of the Taiwanese (54.3%) and Polish (80.3%) participants were distressed by the war scenes in the media. More than half (52.5%) of the Ukrainian participants would not seek psychological help despite a significantly higher prevalence of psychological distress. Multivariate linear regression analyses found that female gender, Ukrainian citizenship, self-rating health status, past psychiatric history and avoidance coping were significantly associated with higher DASS-21 and IES-R scores after adjustment of other variables (p < 0.05).
Conclusion
We have identified mental health sequelae in Ukrainian, Poles and Taiwanese with the ongoing Russo-Ukraine war. Risk factors associated with developing depression, anxiety, stress and post-traumatic stress symptoms include female gender, self-rating health status, past psychiatric history and avoidance coping. Early resolution of the conflict, online mental health interventions, delivery of psychotropic medications and distraction techniques may help to improve the mental health of people who stay inside and outside Ukraine.
OCTA biomarkers in sight-threatening Behcet’s disease-related uveitis treated with adalimumab
Authors: Roshdy Ahmed
Published: October 2022

Purpose: To evaluate retinal microvasculature parameters during Behcet’s uveitis (BU) remission status reached post treatment with adalimumab via optical coherence tomography angiography (OCTA), and compares the results with those from healthy eyes.
Methods: A total of 10 eyes of 10 BU patients presenting during the remission period (within 12 months) of BU involving the posterior segment were enrolled, as were 20 normal eyes of 20 age and sex-matched healthy participants. OCTA images were analyzed. Foveal avascular zone (FAZ), and vessel densities (VD) were calculated and compared.
Results: 10 eyes of 10 BU patients and 20 normal eyes of 20 age and sex-matched subjects were included in the study. At baseline, the all 10 eyes had active retinal vasculitis. Retinal vasculitis resolved in all cases (100%) after starting adalimumab. The mean time to complete resolution of inflammation was 3.4 weeks. None of the patients developed any adverse events associated with adalimumab treatment. The FAZ was higher in the BD group than in the control group (p = 0.01). Both the superficial and deep plexuses vessel densities were significantly lower in BD eyes (p<0.05).
Conclusion: BD can cause irreversible damage to the retinal circulation affecting both SCP and DCP. OCTA gives a full view of the retinal microvasculature. Adalimumab was effective in preventing irreversible sight-threatening BD. Adalimumab treatment appears to be associated with improvement of the retinal blood flow more evident in the DCP thus provide better final visual outcome for cases with BD uveitis
Clinical Significance of combinatorial blockade of novel immune checkpoint B7-H4 with PD-L1 in Urothelial Carcinoma of Bladder: A rational therapeutic approach
Authors: Raja David , Singh Aishwarya , Kurra Santosh , Nayak Brusabhanu , Kaushal Seema , Sharma Alpana , Singh Prabhjot
Published: October 2022

Purpose: Urothelial carcinoma of bladder (UBC) is complex disease with high mortality and recurrence rates. Current standard regimens have exhibited anti-tumor activity however, proportion of patients are non-responsive or ineligible to receive such treatments, which stresses upon identifying new effective options for treating UBC. Immune checkpoints have emerged as potential class of therapeutics to be tested in UBC treatment.
Methods: 40 UBC patients and 30 healthy controls were recruited from whom blood was taken. Histopathologically proven tumors and adjacent normal tissue were obtained from patients. The frequency of T cells and immune checkpoints (B7-H4 and PD-L1) was assessed in circulation. Molecular expression of immune checkpoints has been studied in tumors and normal tissue. In-vitroblocking of B7-H4 alone and in combination with PD-L1 was performed to test for T cell functionality. Finally, these immune checkpoints were correlated with clinico-pathological parameters.
Results: Elevated expression of B7-H4 and PD-L1 were observed in CD8 T cells of UBC patients. Relative mRNA expression and immunohistochemistry displayed upregulation in bladder tumor tissue. Co-blockade enhanced IFN-gand granzyme B of CD-8 T cells. Also, B7-H4 was significantly associated with clinico-pathological parameters.
Conclusion: Increased expression of B7-H4 along with PD-L1 in periphery and tumor of UBC patients highlights involvement of B7-H4 in disease progression, showcasing elevated expression with disease progression. Combinatorial blocking enhanced functional T cell immune response in UBC patients. Also, positive association of B7-H4 with clinico-pathological parameters showcase it as potential therapeutic target for treatment of UBC patient in future after further validation.
Unraveling the contrasting features of rainfall microphysics for the tropical cyclone Tauktae (2021) and a severe thunderstorm event as observed over the orographic region of Western Ghat
Authors: Chakravarty Kaustav , Patil Rohit , Saha Sanjay , Murugavel P , Yadav Prafull , Pandithurai G
Published: October 2022

The contrasting feature of precipitation microphysics for the severe weather events over the orographic region of Western Ghat (WG) has been highlighted in this paper. By analyzing the features of precipitation associated with a cyclone and a thunderstorm over Mahabaleshwar – which is regarded as one of the severe rainfall station of Western Ghat orographic region, it has been found that the raindrops of diameter 2.2 mm and above dominates the precipitation associated with thunderstorm than with respect to cyclone. Though the towering thunderstorm surrounding the eyewalls of cyclone produces rainfall of higher intensity during the cyclonic period, but the strong updraft generated during the thunderstorm rainfall event forces the smaller raindrops aloft thereby allowing the larger raindrops to precipitate locally which ultimately results for severe rainfall of very high intensity for shorter duration during those events. It has been observed that the pre-cyclonic effect over orography is characterized by the increase in midlevel relative humidity (700–900 hPa), relative vorticity and cloud ice water content while in case of evolution of thunderstorm, the atmosphere gives strong signal with respect to strong vertical velocity, sudden increase of CAPE and rapid decrease of Lifting Index (LI). In this study, the impact of orographic upliftment, cyclonic circulation and the stronger updraft generated during the thunderstorm period has been critically diagnosed, differentiated and portrayed with respect to the variation of rainfall microphysics for these severe weather events over the elevated terrain.
Comparison of two sampling methods of detection of bacterial contamination in the hospital environment: moistened swabs versus RODAC agar plate
Authors: Li Yaru , Li Leilei , Chen Feng , Wang Dong , Peng Yaping , Wang Wanqiu , Sun Xiaxia , Deng Jianjun
Published: October 2022

Purpose: This study aimed to investigate the efficiency of two different sampling methods (swabbing, and RODAC (replicate organism detection and counting) agar plate) in terms of detection of bacterial contamination, and their suitability as monitoring methods for partition curtains and other medical textiles.
Methods:A total of 24 beds were selected by stratified random sampling .The swabbing technique and RODAC agar plates were the chosen sampling methods. The colony forming units were calculated and colony morphologies and strains on the plates were observed and identified after culturing.
Results:A total of 192 samples collected. Of them, 161 pathogenic strains were isolated via the swabbing technique; 309 pathogenic strains were isolated using the RODAC agar plates. The swabbing technique had a higher detection rate for Gram-positive bacteria (P = 0.0004) , while RODAC agar plate had a higher detection rate for Gram-negative bacteria (P = 0.72).The detection of bacterial contamination rates using the swabbing technique was superior to that of the RODAC agar plate method (P < 0.001).
Conclusions: The swabbing technique offers more advantages in terms of detection of bacterial contamination rates and Gram-positive bacteria, while the RODAC agar plate is more sensitive to the inspection of Gram-negative bacteria.
A Feature Modeling Based Bidding Trading Mechanism in Power Blockchain
Authors: Lv Zhixing , Yu Hui , Kang Kai , Li Teng-Chang , Du Guo-Li
Published: October 2022

With the improvement of the requirement of power service and marketization of the power industry, how to reasonably trade and effectively utilize power has become an emergent problem. Due to the centralized trade mode in the traditional power, many issues, including long-term processing, high trading cost, lack of supervision, and potential attack risk, are inevitable. It means that the feasible, effective trading processing rules is required. As an innovative information technology, blockchain has combined the advantages of decentralization, immutability, data provenance and automatically contract operation, which can be used to solve the abovementioned issues. Taking the credibility and activity into account, a feature modeling based bidding trading mechanism in power blockchain is proposed. Such a mechanism is deployed and executed in the manner of smart contract. The extensive experimental results demonstrate that the proposed mechanism is feasible and effective, which can be applied to large-scale power trading scenarios, thus having the practical value.
Effect of resin tapping system and collection period on resin production and growth traits in 12-year-old Pinus elliottii var. elliottii
Authors: Freitas José Antonio , Neto Antônio Orlando Luz Freire , Bucci Luís Alberto , Souza Talita Carvalho , Menucelli João Roberto , Amorim Erick Phelipe , Aguiar Ananda Virgínia , Lima Israel Luiz , Longui Eduardo Luiz
Published: October 2022

Resin tapping is an activity designed to extract resin from trees, especially species of the genus Pinus. Current systems of tapping and collecting resin are well known, but further study is needed to make these systems more efficient and profitable for producers. Therefore, this work aimed to evaluate the effect of five resin tapping systems during five different collection periods on the production and growth of resin trees for a population ofPinus elliottiivar.elliottiiplanted in Itapetininga, SP. Resining affects tree growth, especially in diameter. Results showed that system 4, with eight panels on each plant and four on each side, presented the highest average production of resin per tree, while system 1, with 2 panels on each plant and 1 on each side, presented the lowest average resin production per tree. It was concluded that resin production is dependent on the system employed, time of collection, and their interactions.
Production of Highly Porous Electrospun α-Fe2O3 Nanofibers For Environmental Applications
Authors: ALP Emre , BORAZAN İsmail
Published: October 2022

The electrospun α-Fe2O3 nanofibers with mesoporous were fabricated by annealing electrospun Poly(acrylonitrile-co-vinyl acetate) (PAN)/Iron(III)chloride and Poly(acrylonitrile-co-vinyl acetate) (PAN)/Iron(III)chloride hexahydrate composite nanofibers. The used precursor for the iron source drastically affected the final morphologies of the electrospun α-Fe2O3 nanofibers depending on whether it was hydrated. As a result of that, the photocatalytic performances of electrospun α-Fe2O3 nanofibers exhibited significant differences from each other. It was observed that the electrospun α-Fe2O3 nanofibers with highly porous, derived from a hydrated iron salt source, exhibited excellent photocatalytic activity against synthetic dye with anionic and cationic. The results here suggest that the electrospun α- Fe2O3 nanofibers with highly porous were fabricated in the study, which exhibited excellent photocatalytic activity, can provide promising activities to remove organic contaminants from wastewater. Likewise, these nanofibers with highly porous can show high performances in solar-related applications such as water splitting and photovoltaics.
A qualitative study of junior doctors attitude towards near peer teaching
Authors: Anderson Joseph , Carton Eleanor , Silva Ana Sergio Da
Published: October 2022

Background
Learner benefits of Near-Peer Teaching (NPT) are evidenced in literature but the experience of junior doctors participating in NPT is only beginning to be explored. This study explores qualitatively the attitude of junior doctors towards NPT using a cognitive-affective-behavioural model.
Methods
Junior doctors a tertiary teaching hospital in Ireland participated in semi-structured interviews conducted by a peer-researcher, which were audiotaped, transcribed, coded using NVIVO, and thematically analysed.
Results
Four main themes were identified. Near-peer teaching was perceived as an enjoyable and satisfying role of a clinician. Near-peer teachers believed that NPT was beneficial to both teachers and learners. Participants acknowledged that knowing one’s limitations is vital to safe teaching practice. A structured approach to NPT programs was suggested to improve the efficiency and participation of teachers and learners.
Conclusion
This study documented the personal Learning experience, an enjoyable and satisfying teaching experience, and the perceived teacher and learner benefits as the motivational factors and the main challenges of junior doctors towards NPT were personal limitations, learner disengagement, and the lack of time, resources, and a structured NPT program. Suggestions to improve the participation of learners and teachers in NPT were identified and discussed.
Pedestrian trajectory prediction model for spatio-temporal graph networks combined with speed control
Authors: Shen Eric Z.
Published: October 2022

The most important task in pedestrian trajectory prediction is to build a pedestrian trajectory interaction model. To address the lack of information about time and speed in the model, a spatio-temporal graph network algorithm with speed control is proposed to build a pedestrian interaction model and predict the trajectory. The overall model adopts a conditional adversarial network architecture, in which the velocity prediction module is used to predict the final velocity of the pedestrian as the control condition of the conditional adversarial network, and the velocity information is explicitly introduced into the pedestrian trajectory prediction to avoid the influence of large deviation of velocity on the trajectory. The spatio-temporal information fusion module based on the graphical convolutional attention mechanism is designed in the generator to explicitly encode the temporal correlation of pedestrian trajectory sequences while extracting their motion features and focusing on their spatial interactions. Finally, the trajectory prediction is completed by decoding the trajectory interaction features combining spatio-temporal and velocity information. In addition, considering the shortage of existing evaluation methods, the average number of collisions is used as the judgment of trajectory reasonableness. The experimental results show that the proposed algorithm can better predict the pedestrian trajectory with the average displacement error of 0.40m and the final displacement error of 0.79m.
FINANCIAL ANALYSIS AND AUDIT OF FOREIGN ECONOMIC ACTIVITY OF THE ENTERPRISE IMPROVING
Authors: Zhukova T. , Basanets I. , Plikus I.
Published: October 2022

Foreign economic activity of the enterprise is of significant importance in the development of Ukraine’s economy. Due to foreign fund raising into the development and opening new enterprises, economic indicators are improving in the country as well as the opportunities for Ukrainian enterprises to reach the international level are increasing. The article provides a detailed analysis of auditing in Ukraine. The dynamics of foreign direct investment inflows is analyses. It is justified that the development of international business requires an audit to confirm the financial reports of enterprises engaged in foreign economic activity. The priority areas of foreign economic activity audit are researched and analyses. It is proved that when auditing foreign economic activity, it is reasonably to consider not only practical aspects, but also to analyses scientific methods of auditing in the international market to strengthen the financial security of individual entities of foreign economic activity in particular and the country as a whole. Such integration provides an opportunity to develop and improve both independent auditing and state tax control. It is noted that the control of economic entities that are registered in countries with low-income tax rates is considered to be an important aspect. It is emphasized that the audit of foreign economic activity should take into account fraudulent schemes and accounting violations that may be committed in order to evade taxes. The study and analysis of offshore zones on the correctness of doing business is also important. The article analyses the dynamics of foreign economic activity as well as exports and imports of Ukraine to the countries with low tax rates in 2020. The characteristics of audit methods of foreign economic activity is given and it is proved that these methods of management decisions concerning the risk assessment of foreign economic activity will help to identify negative consequences of operations in foreign economic environment and maximize the possibility of obtaining high financial results.
CORRELATION OF CLINICAL RISK SCORES WITH ANGIOGRAPHIC EXTENT AND SEVERITY USING MODIFIED GENSINI SCORE IN PATIENTS WITH ST ELEVATED MYOCARDIAL INFARCTION
Authors: Palagiri Shafi , Nrushen Peesapati , Shafeeque Ahmad Salman
Published: October 2022

Cardiovascular diseases have emerged as a significant health burden and became a leading cause of mortality in developing countries like India.In cardiovascular diseases, acute coronary syndromes are the primary cause of morbidity and mortality, for which timely diagnosis and appropriate therapy are of foremost importance to improve clinical outcomes.Different scoring systems are now available based on initial clinical history, electrocardiographic and laboratory tests that enable early risk stratification on admission. The risk scores were created and recommended by national and international guidelines to identify patients with a higher probability of adverse events, recommending more intensive treatment and early angiography in this population.In this study, we considered evaluating clinical predictors and suitable risk scores GRACE and TIMI that correlate with the severity of angiographic extent of coronary artery disease in patients presenting with ST-elevation myocardial infarction using Modified GENSINI score.
A CASE REPORT OF PSEUDO WELLENSSYNDROME IN PATIENT WITHPULMONARYEMBOLISM
Authors: EL Amraoui Asmaa , Jazouli A.EL , Mousaid M.EL , Haboub M. , Arrous S. , Bennouna G. , Drighil A. , Azzouzi L. , Habbal R.
Published: October 2022

Wellens syndrome is described asbiphasic or deeplyinverted T waves in the precordialleads thatis indicative of criticalstenosis of the leftanteriordescendingartery. It isseenin a subset of patients withunstableanginaduring the pain-free interval. . Similar characteristic ECG changes associated with causes other than LAD stenosis have been described as pseudo-Wellens syndrome. In this case report, we present a young 31-year-old man who presented with characteristic Wellens ECG changes in the setting of pulmonary embolism with right ventricular strain., biphasic T waves in the setting of pulmonary embolism are rare. Pulmonary embolism was seen in our patient three weeks after starting risperidone. There is a reported association between antipsychotic drugs and increased risk of thromboembolism. Risperidone could have potentially contributed to the pulmonary embolism in our patient given the temporal association and absence of risk factors.
GUN LAWS IN CONTEMPORARY AMERICA
Authors: Kochhar Sahira
Published: October 2022

This article will provide a critical analysis of the causes and impacts of gun violence and the contemporary mass killings in the USA, assessing the effectiveness of federal firearm laws such as stand-your-ground, open carry, and permit laws in tackling the issue. This article places emphasis on the factors responsible for these incidents and how they were shaped, along with their immediate and long-term impacts. The significance of the Second Amendment will also be explored, along with how it is interpreted. Therefore, it will explore whether existing gun laws in the USA make it all the more difficult to bring about a sense of peace and justice in the country. After all, given the current political climate and soaring rates of gun violence in the USA, the impacts of gun laws on crime rates are important to explore. To further the investigation, this statement will be evaluated via the examination of gun laws and recent incidents.
Breeding of highly productive sugar beet hybrids with improved beet root shape
Authors: Parfeniuk O. O. , Trush S.H.
Published: October 2022

Purpose. Isolation of donors of valuable breeding and genetic traits and the creation of a new source material for the selection of parental components of sugar beet hybrids according to the shape of the root. Evaluation of the productive potential of experimental sugar beet hybrids with improved root shape parameters.
Methods. Field (experiments, phenological observations), laboratory (determination of sugar content), measuring and weighing (determination of crop structure), statistical (mathematical processing of research results).
Results. The results of the evaluation of the basic productivity of parental components of different genetic structure and productivity of experimental sugar beet hybrids with improved root shape are presented. An increase in the yield of root crops, sugar yield and sugar output per unit area in sugar beet hybrids on a cytoplasmic male-sterile (CMS) basis, created using multigerm pollinators with an improved root crop shape (oval-conical), has been established.  Experimental hybrids formed on the basis of first generation of multigerm pollinators of backcross (BC1) prevailed the group standard in root crop yield by 15.2–22.8%, sugar yield and sugar output by 14.4–19.4% and 11.5–17.5%, respectively. The sugar content was below or at the level of the group standard. Similar indicators of hybrids formed on the basis of pollinators of the second generation of backcross (BC2) were 14.0–21.2%, 17.0–23.2% and 17.6–23.9%, respectively. The sugar content was at the level of the group standard. Root shape index indicators were 1.32 and 1.28, respectively. The hybrids formed using the initial multigerm pollinators were characterized by a conical root shape (shape index – 0.61). According to indicators of yield, sugar yield and sugar output per unit area, they were at the level of the group standard.
Conclusions. It was established that the shape of the root crop is an important factor in improving the productive potential of sugar beets in selection for heterosis. The change in the shape of the root crop from conical to oval-conical leads to an increase in the productivity of multigerm pollinators of sugar beets by 8–19% and hybrids created with their participation by 17–23%.
Yielding capacity and flour-milling properties of spring bread wheat varieties depending on growing environmental conditions
Authors: Vasylenko N. V. , Pravdziva I. V.
Published: October 2022

Purpose. To determine the dependence of yield and flour-milling properties of new spring bread wheat varie­ties of Myronivka breeding on different growing season conditions.
Methods. During 2017–2019, twelve spring bread wheat varieties were studied in the conditions of the V. M. Remeslo Myronivka Institute of Wheat of NAAS. Grain and flour qua­lity indicators were determined according to conventional methods.
Results. It was found that weather conditions in 2019 were more favorable for realizing the yield potential of spring wheat varieties, but they had a nega­tive impact on quality indicators. By exceeding on 30–40% the standard ‘Elehiia myronivska’, the varieties – ‘Bozhena’ (4.23 t/ha), ‘Oksamyt myronivskyi’ (4.28 t/ha), ‘MIP Svitlana’ (4.31 t/ha), and ‘Dubravka’ (4.62 t/ha) were selected in terms of yield. The varieties ‘Simkoda myronivska’, ‘MIP Zlata’, ‘Bozhena’, ‘MIP Vizerunok’, and ‘MIP Oleksandra’ were singled out by the combination of high physical indicators of grain quality. The varieties ‘Simkoda myronivska’, ‘Oksamyt myronivskyi’, and ‘Panianka’ were distinguished by complex of the highest flour quality indicators. The varieties being the most stable in terms of individual characters were identified. These were ‘Simkoda myronivska’, ‘MIP Zlata’, ‘Bozhena’, ‘Oksamyt myronivskyi’, ‘MIP Svitlana’, and ‘MIP Oleksandra’ by yiel­ding capacity. According to quality indicators, in particular, by 1000 kernel weight, varieties ‘Simkoda myronivska’, ‘MIP Vizerunok’ were distinguished; high scores for grain vitreousness were in most varieties, except for ‘Elehiia myroniv­ska’, ‘Simkoda myronivska’, and ‘MIP Oleksandra’; according to test weight and flour yield, all varieties had high rates; according to the protein content, the variety ‘Oksamyt myronivskyi’ was distinguished; varieties ‘Dubravka’ and ‘MIP Oleksandra’ by wet gluten content. The ANOVA established that the most dependence on weather conditions was revealed for such parameters as 1000 kernel weight (part of influence 83.7%), protein content (76.7%), sedimentation value (66.7%), flour yield (52.6%), gluten deformation index (46.0%), and wet gluten content (42.6%); the most dependence on the interaction of factors year  variety was revealed for yielding capacity (52.3%), the grain vitreousness (50.5%), and the test weight (36.5%). A reliable effect of the factor variety on yield (34.9%) and all investigated quality indicators (5.1–35.1%) was revealed.
Conclusions. It is expedient to use the varieties listed above as sources of certain traits for the creation of new high-yielding and high-quality varieties for different areas of use.
Influence of barrier effect on barrier sheet pile wharf
Authors: Zhang Hao , Zhu Huaxin , Zhang Defeng , Wang Jie , Zhang Chenxing , Novák Drahomír
Published: October 2022

This study aims to investigate the barrier effect of front wall-soil-barrier interactions in barrier sheet pile wharf structures. Berth 32 of the Jingtang Port was taken as the prototype structure, and the prototype observation experiment, centrifugal model test, and numerical calculation analysis were performed to study the influence of the length of the barrier pile, the spacing D between wall piles, and the net spacing L of the barrier pile on the barrier effect. The results show that, to maximize the barrier effect, the ratio N of the pile length of the full barrier pile to the depth of the front wall should be between 1.0 and 1.1. To maximize the barrier effect, the top elevation of the semi-barrier pile should not be excessively low. When the bottom elevation is fixed, the ratio of the length of the semi-barrier pile to the depth of the front wall is approximately N= 0.7. The change in the wall pile spacing D has a considerable impact on the barrier effect. Moreover, D has a logarithmic relationship to the horizontal displacement of the front wall. When D exceeds 3 m, the change in the barrier effect can be ignored. The part of the earth pressure shared by the sea and land sides of the barrier pile to the soil between the barrier pile and the barrier pile has a logarithmic relationship to the net spacing L of the barrier pile. The smaller the L, the better the barrier effect. When L exceeds 2 m, the earth pressure shared by the two parts tends to be average, and the barrier effect can be ignored.
A Rare Case of Enteric Fever with Multiple Splenic Abscesses: Case Report
Authors: Bose Vaishnavi , Thomas Ajith Cherian , Hussein Hazem Elsayed , Junaid Sana , Younas Nadeem Javed
Published: October 2022

Background:

Enteric fever is a common infection found in many developing countries around the world, which often has life- threatening complications if not treated promptly. One of the rarest complications of enteric fever is splenic abscess.

Case presentation:

Our case is that of a 32-year-old male, admitted with febrile illness, diagnosed as typhoid fever (enteric fever) with rare complication- multiple splenic abscesses, after his travel to endemic area, which was effectively treated with antibiotics under inpatient setting.

Conclusion:

Early diagnosis with imaging modalities such as computed tomography can lead to better treatment approaches. Splenic abscesses are often treated with antibiotics or conservative treatment; however, non-responsive cases may require splenectomy.
Prediction Models based on miRNA-disease Relationship: Diagnostic
Relevance to Multiple Diseases Including COVID-19
Authors: Sharma Anil K. , Sharma Varruchi , Yadav Mukesh , Sehrawat Nirmala , Kumar Vikas , Kumar Sunil , Gupta Ajay , Sharma Pooja , Chakrabarti Sasanka
Published: October 2022

Background:

Small, non-coding microRNAs, usually of 20-25 nucleotides, are known to
regulate the post-transcriptional gene expression, which has a significant role in human biological
processes, including immune-biogenesis, homeostasis and infection control as differential expression
of such miRNAs is responsible for fine-tuning the organismic development.

Methods:

A search of bibliographic databases was carried out with a focused question on microRNA-
Disease Prediction. A deductive qualitative content analysis approach was employed to
assess the research's overall outcomes, review articles on prediction tools in miRNA-Diseases, and
analyse the interventions.

Results:

Diagnosis and therapeutics of diseases and miRNA prediction methods hold importance in
identifying the regulatory mechanisms. Collections of efficient miRNA prediction methods to identify
miRNA-mRNA-disease regulatory relationships have been presented through this review, consolidating
the potential of miRNAs as a diagnostic and prognostic biomarker of multiple diseases,
including COVID-19.

Conclusions:

The role of miRNA in the aetiology and pathogenesis of wide-range of pathologies,
including viral, bacterial to chronic diseases such as cancer, is quite feasible through the modern
tools in bioinformatics which has been elaborated focusing upon miRNA-disease prediction methods
and their application potential establishing miRNAs as a robust and reliable biomarker in clinicomedical
studies.
Progress in Quantitative Methods for Azelnidipine and Chlorthalidone:
An Analytical Basis for a Recently Approved FDC
Authors: Kotadiya Rajendra , Raimalani Juhi
Published: October 2022

Backgroound:

Products with multiple active substances mixed in a single dosage form are fixed-dose combinations. These are justified for a variety of reasons. These include a) increasing therapeutic efficacy, b) lowering adverse drug effects, c) pharmacokinetic advantages, d) lowering pill load, e) lowering individual drug doses, and f) lowering drug resistance development.

Objective:

A recently approved fixed dose combination of azelnidipine (8 mg) and chlorthalidone (6.25 or 12.5 mg) is indicated to treat hypertension. Individual quantification methods for azelnidipine and chlorthalidone are available, but no practical and acceptable analytical approach for their combination has been documented. As a result, the goal of this literature review was to gather information on the numerous analytical instrumental approaches utilized to quantify azelnidipine and chlorthalidone in diverse matrices individually. The scientific community could use this information to design a new analytical method for analysing the recently approved combination.

Methods:

Authors have explored various scientific databases to obtain information on analytical methods.

Results:

The methods listed for azelnidipine and chlorthalidone are spectroscopy, high-performance liquid chromatography, hyphenated techniques, high-performance thin-layer chromatography, thin-layer chromatography, and a few other approaches. For azelnidipine and chlorthalidone, there were 26 and 46 research papers reported, respectively.
A Bayesian Network Analysis of the Efficacy of Scaffolds and Stem Cells in
Spinal Cord Injury Treatment
Authors: Wang Yang , Yi Hanxiao
Published: October 2022

Backgrond:

Novel scaffolds and stem cells are alternatives for the treatment of spinal cord
injury (SCI), which causes life-long disability. However, there is a lack of synthesized evidence comparing
different therapies.

Aim:

To examine the efficacy of various treatments in achieving locomotor recovery in SCI animals. The
PubMed, Scopus and Web of Science databases were searched from inception to 21st May 2021.

Methods:

The data were extracted by one investigator under the surveillance of a referee according to the
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement and
stored in Microsoft Excel. All data were analysed using Bayesian network analysis with a consistency
model. The selection was performed in strict accordance with the participant, intervention, comparison,
outcome and study (PICOS) principle, as specifically stated in the methods section.

Results:

A total of 387 eligible studies involving 11169 animals subjected to 5 different treatments were
evaluated. Compared to placebo or no treatment, scaffolds (mean difference (MD), 2.04; 95% credible
interval (CrI): 1.58 to 2.50), exosomes (MD, 3.46; 95% CrI: 3.07 to 3.86), stem cells (MD, 4.18; 95% CrI:
3.28 to 5.07), scaffolds in conjunction with stem cells (MD, 5.26; 95% CrI: 4.62 to 5.89), and scaffolds in
conjunction with non-cell agents (MD, 4.88; 95% CrI: 4.21 to 5.54) led to significant recovery of locomotor
function in SCI animals. No significant difference in the locomotor function score was observed between
animals treated with stem cells and those treated with exosomes (MD, 0.71; 95% CrI: -0.25 to
3.05), between animals treated with scaffolds in conjunction with stem cells and those treated with scaffolds
in conjunction with non-cell agents (MD, -0.38; 95% CrI: -1.24 to 0.49), or between animals treated
with scaffolds in conjunction with non-cell agents and those treated with stem cells (MD, 0.71; 95% CrI: -
0.38 to 1.80).

Conclusion:

Significant differences in the efficacy of various therapies in SCI animals were observed,
and transplantation of scaffolds in conjunction with non-cell agents, scaffolds in conjunction with stem
cells, and stem cells should be considered over transplantation of exosomes or scaffolds alone. Even
though transplantation of scaffolds alone promoted locomotor function recovery in SCI animals, its use
should be discouraged.