bluuebunny/crossref_metadata_2025 huggingface dataset:
DE OLHOS BEM FECHADOS: A POTÊNCIA DO OLHAR CINEMATOGRÁFICO
Authors: Kirst Marina Gomes , Weinmann Amadeu de Oliveira
Published: September 2023

O artigo assinala a potência do olhar na experiência cinematográfica, buscando contribuir para a tradição da análise fílmica. O filme De olhos bem fechados (1999), de Stanley Kubrick, serve como fio condutor e objeto de estudo. Usamos o método da análise fílmica psicanalítica, em conjunto com uma revisão bibliográfica da literatura de conceitos lacanianos como o olhar e o semblante, para explorar a questão: em De olhos bem fechados, como o olhar irrompe na tela? Nossa hipótese é de que, onde a fantasia fílmica falha, a verdade sobre o semblante é revelada e o olhar cinematográfico surge como potência libertadora.
A TRANSMISSÃO E FORMAÇÃO EM PSICANÁLISE: IMPASSES NA CULTURA
Authors: Perrone Cláudia Maria , Britz Eduardo Bayon
Published: September 2023

O artigo examina questões do ensino e da transmissão da psicanálise partindo da análise de um fenômeno da cultura brasileira, os cursos de graduação em psicanálise e da psicanálise “evangélica”. As novas institucionalizações da psicanálise, seguindo a forma adaptativa da identificação, operam através da identificação maciça com o analista/pai/pastor, situação de alto risco quando a propensão ao autoritarismo e ao preconceito é estimulada pela dinâmica social dominante e pelas formas culturais regressivas com maior poder de disseminação. As tendências subjetivas estruturantes estariam, deste modo, sendo estimuladas pela sociedade e pela cultura: convencionalismo, agressividade, oposição a tudo que é intelectual e subjetivo, submissão autoritária.
FORMAÇÃO EM PSICANÁLISE, TRANSMISSÃO DA PSICANÁLISE: REAL, TRAUMA, RITO
Authors: Binkowski Gabriel Inticher
Published: September 2023

Este artigo propõe que a formação em psicanálise e sua transmissão constituem modalidades de tratamento do encontro com o real e o traumático da experiência analítica. Essa experiência retoma na singularidade do sujeito dramas que estão na base do recalque que engendra a cultura, o social, e que cimentam a civilização como um esforço de amparo e, ao mesmo tempo, de inibição e controle. Propomos que essa ideia tem consequências importantes para pensar a história e a configuração institucional da psicanálise e de seus ritos de formação e de transmissão, assim como a possibilidade de que o discurso analítico possa produzir efeitos a partir do sujeito da modernidade.
ATRAVESSANDO UMA LINHA DE SOMBRA: UMA APROXIMAÇÃO AO DESCONHECIDO
Authors: Berlino Camila Mangolim , Costa Paulo José da
Published: September 2023

O que se viverá na situação analítica entre um paciente e seu analista, embora submetido a regras específicas, será sempre desconhecido. Isso pode ser ao mesmo tempo apavorante e instigante. Muitos autores falam sobre esse encontro; aqui, baseou-se principalmente em Bion e buscou-se o auxílio da literatura para que se pudesse aprofundar o entendimento do que se vive emtal situação. Pensou-se em uma travessia não apenas com características desconhecidas, mas através do Desconhecido. Assim, buscando uma aproximação possível desse fenômeno com a clínica psicanalítica, temos como objetivo no presente trabalho analisar a ideia de Desconhecido, a qual está presente no fazer psicanalítico. Tomamos o encontro com a literatura na análise do livro A linha de sombra, de Joseph Conrad, como um recurso para ilustrarmos e buscarmos ampliar a discussão. Aproximou-se da ideia de encontros que demandam desconstrução para que novos arranjos e mesmo criações inéditas possamemergir.
CASTORIADIS: A IMAGINAÇÃO RADICAL E O INCONSCIENTE PÓS-LACANIANO
Authors: Urribarri Fernando
Published: September 2023

A interpretação abstrata de Castoriadis sobre Freud centra-se na ideia da imaginação radical. A introdução deste conceito na psicanálise tem consequências que afetam todos os níveis do projeto freudiano. Na opinião de Castoriadis, as percepções fundamentais de Freud não estão em disputa discussão/controvérsia, mas a referência à imaginação faz possível articulá-las em novas formas e construir pontes novas entre a psicanálise e a teoria social. Em sua capacidade como fonte da representação e do sentido significado, a imaginação radical é – junto com a pulsão – a "cofundação co-fundadora da psique". Uma reflexão ulterior, conduz Castoriadis a radicalizar o conceito do inconsciente e a introduzir a noção da mônada psíquica. Ao mesmo tempo, porém, seu conceito revisado de sublimação liga a psique ao mundo social-histórico. Em todas essas considerações, há afinidades significativas entre o trabalho de Castoriadis e as correntes pós-lacanianas da psicanálise francesa.
Factores criminológicos del tráfico ilícito de drogas en el medio ambiente
Authors: Tello Camino Roxana , Jara Bocanegra César Miguel , Puente Auccapoma Omar Romel
Published: September 2023

El tráfico de drogas es una actividad económica ilegal, la cual implica el cultivo, crecimiento, manufactura, distribución y venta de sustancias prohibidas por la legislación, cuyo accionar es atribuido a organizaciones delictivas, según la configuración de la estructura necesaria para tal delito y otros ilícitos asociados. Dadas las consecuencias a delitos conexos, así como a la presencia de otros delitos y la degradación medioambiental; para el entendimiento de este delito ha surgido la llamada Green Criminology, la cual ha develado la compleja e intrincada red asociada a tal delito y otras economías. Aunado a lo anterior, diversos estudios han evidenciado la presencia de factores químicos y territoriales que se asocian al tráfico ilícito de drogas, las mismas que gradualmente han socavado y ponen en peligro la biodiversidad de los ecosistemas.
Fotografie als literarischer Metaphernfundus in Nino Haratischwilis Roman Das mangelnde Licht
Authors: Ivanova Ralitsa
Published: September 2023

Längst hat die alltägliche Präsenz der visuellen Medien die Wahrnehmungsformen des Menschen beeinflusst und zu Verschiebungen in der Hierarchie der Darstellungs- und Kommunikationsformen geführt. Im Kontext dieses visual turn untersucht der vorliegende Beitrag die literarische Metaphorisierung der Fotografie in Nino Haratischwilis Roman Das mangelnde Licht. Erörtert werden verschiedene metaphorische Spielarten des fotografischen Mediums sowie dessen Überlappung mit der Technik des Restaurierens und des Zeichnens.
Die standardisierte Rahmenstruktur deutscher Anklageschriften und Besonderheiten ihrer Übertragung ins Bulgarische
Authors: Kileva-Stamenova Reneta
Published: September 2023

Auf der Grundlage einschlägiger theoretischer Ansätze zur Rechtsübersetzung befasst sich der Beitrag mit Problemen der Übersetzung von Anklageschriften aus dem Deutschen ins Bulgarische. Im Mittelpunkt der Betrachtung steht die konventionalisierte Rahmenstruktur dieser Textsorte in beiden Rechtsordnungen, die einem interlingualen Vergleich unterzogen wird. Die daraus gewonnenen Erkenntnisse werden neben anderen Kriterien bei der Erstellung von zwei Musterübersetzungen ins Bulgarische – der Rahmenstruktur der norddeutschen bzw. der Rahmenstruktur der süddeutschen Variante der Anklageschrift – berücksichtigt. Ein Kommentar der Musterübersetzungen und ihrer Anwendbarkeit in der Übersetzerausbildung und in der Übersetzungspraxis rundet den Beitrag ab.
No difference in chick-provisioning by bridled and non-bridled Common Guillemots Uria aalge
Authors: Barrett Robert
Published: September 2023

Despite recent evidence that bridled Common Guillemots Uria aalge may depend more on cold-water prey species than non-bridled, there was no morph-specific difference in the species composition or size of fish caught for chicks by adults in a North Norwegian colony. This supports the recent suggestion that selection pressure on the morphs acts in the non-breeding season, rather than in summer.
Recent changes in the status and distribution of moulting Common Eiders Somateria mollissima in Shetland
Authors: Heubeck Martin , Mellor Mick
Published: September 2023

Common Eiders Somateria mollissima in Shetland are believed to be essentially resident within the archipelago, and may be closer to S. m. faeroensis than to S. m. mollissima, the subspecies found in mainland Scotland. Surveys during the late summer moulting period indicated the population in Shetland declined from an estimated 15,500 birds in 1977 (subsequently revised to 17,000) to c. 6,000 by 1997. Further surveys in August 2009 and August 2012 located 5,782 and 4,627 birds, respectively. The 2009 count suggested little change in numbers since the late 1990s, whilst the 20% difference between 2009 and 2012 is believed to represent a genuine decrease rather than any artefact of survey coverage or accuracy. The distribution of moulting Eiders changed fundamentally during the 2000s, from traditional sites on the exposed, outer coastline to the vicinity of shellfish and finfish aquaculture sites on the sheltered, inner coastline; by 2009-12 approximately two-thirds of the moulting population was associating with aquaculture sites. The reason for the recent decrease in the population is unknown, but possible contributory factors discussed include mortality from oil pollution, deterrence measures taken at aquaculture sites, and predation by marine mammals, especially by Killer Whales Orcinus orca.
Population and breeding dynamics of European Shags Phalacrocorax aristotelis at three major colonies in Shetland, 2001-15
Authors: Heubeck Martin , Mellor R. , Gear Sheila , Miles Will
Published: September 2023

In the 1998-2002 Seabird 2000 census, Shetland held 19% of the British and Irish breeding population of European Shags Phalacrocorax aristotelis (32,300 apparently occupied nests - AON), and the three largest colonies in Shetland (Fair Isle, Sumburgh Head and Foula) together held 44% of the total for the county. Subsequent monitoring at these colonies recorded substantial decreases in population size in 2004-05,2008 and 2011-13. This paper describes European Shag population and breeding dynamics at these three colonies for the period 2001-15, using annual monitoring data for six demographic parameters. Demographic changes were characterised by major reductions in breeding population size (AON), timing of breeding getting later, and considerable reductions in the percentages of nests that progressed to incubation and to hatching, and in overall breeding success. The 2004 and 2005 breeding seasons were exceptionally poor in Shetland but also at colonies elsewhere in north and east Scotland, apparently reflecting large-scale scarcity of sandeel Ammodytes prey. There was no such Scotland-wide (or Shetland-wide) uniformity in these breeding parameters in 2008 or 2011-13, when local food availability within foraging ranges of colonies appeared to be the main driver of European Shag breeding performance in Shetland. At Fair Isle, Sumburgh Head and Foula, breeding was markedly early in 2014 and 2015, and percentage incubation, percentage hatching and overall breeding success were all high. However, population sizes at these colonies remained low in 2014-15, with a combined deficit of c. 2,600 AON in comparison with the Seabird 2000 census figures. Possible mechanisms driving this situation, for example persistent non-breeding, emigration, or high mortality are evaluated. Given the high colony fidelity of European Shags once established as breeders, it is assumed these 'missing' birds are dead. Support for this assertion comes from the Shetland beached bird survey which indicated high mortality in late winter in 2003, 2011 and 2014, in the latter two years associated with prolonged gales. European Shag has recently been added to the UK Red list because of severe population decline, and continued (indeed enhanced) monitoring and ringing of the species is to be encouraged.
Common Tern Sterna hirundo and Arctic Tern S. paradisaea hybridization produces fertile offspring
Authors: Mostello Carolyn , LaFlamme Derek , Szczys Patricia
Published: September 2023

This study provides the first molecular evidence for hybridization between Arctic Terns Sterna paradisaea and Common Terns S. hirundo. We studied a mixed pair (P1; male Arctic Tern and female Common Tern) and its offspring on Penikese Island, Massachusetts, USA in 2007–2015. The pair maintained a long-term pair bond (8 years); its reproductive performance was comparable to that of Common Terns and higher than that of Arctic Terns at the site. Molecular analyses confirmed that all young raised by the pair (at least 5 males and 4 females) were biological offspring. We describe hybrid young and the adult hybrid in detail to facilitate field identification. Although F1 hybrid young were intermediate between the parent species in certain characteristics, dark feathers extending below the eye, in particular, gave them a distinctly Arctic Tern-like appearance; however, all had secondary feathers that were darker than the wing-coverts, like Common Terns. We detected one male F1 hybrid that returned to breed; it retained some features intermediate between the parent species, but we qualitatively judged it to be more Common Tern-like. It mated with a Common Tern and produced three confirmed backcross hybrid young that closely resembled Common Terns. We speculate that rarity of Arctic Terns, especially females, at and near the study site and age/inexperience of the Common Tern parent were proximate mechanisms for the formation of the P1 pair. Further, because mixed pairs are occasionally observed and hybrids are cryptic, we suggest that Arctic/Common Tern hybridization may occur more commonly than is currently realized.
Status, origin, and population level impacts of Atlantic Puffins killed in a mass mortality event in southwest Norway early 2016
Authors: Anker-Nilssen Tycho , Harris Mike , Kleven Oddmund , Langset Magdalene
Published: September 2023

The typical life history of long-lived seabirds makes their populations extra sensitive to decreases in adult survival. It is therefore important to uncover the extent, causes and consequences of any incident that involves massive die-offs of such species. Towards the end of a stormy winter, large numbers of dead Atlantic Puffins Fratercula arctica were beached in Vest-Agder and Rogaland counties, southwest Norway in February and March 2016. There were also reports of smaller numbers of birds found further north along the Norwegian coast, but it was not possible to assess the total extent of the wreck directly. The first birds stranded on 31 January, the day after the storm Gertrude (in Norway named Tor) caused the strongest winds ever recorded in Norway. Post-mortem examinations of 200 carcasses collected in the two counties over the following two months indicated that 59% of the birds were adults, whereas 9% were first-winter birds. Virological examination of three birds tested negative for Influenza A. All birds were emaciated and lacked significant fat deposits, and had presumably starved to death. Most birds, especially among adults, were in the last stage of primary moult, and had probably been flightless only a few weeks earlier. This may help explain why the different age groups were so disproportionately affected. The mean wing length of adults not in active moult indicated the birds originated mainly from colonies on the east coast of the UK. This conclusion was in accordance with the origins of eight ringed birds found dead in connection with the incident, seven of which were adults with a mean age of at least 21.6 years. It also fits well with results from recent tracking studies of birds with geolocators. The apparent survival of adult birds breeding on the Isle of May, southeast Scotland, was much lower between 2015 and 2016 than in most other years, which, unlike what has been possible for many other incidents, demonstrates that this wreck probably had a serious impact on the population level.
Pseudo-egg “fabrication” by Grey-headed Albatrosses Thalassarche chrysostoma on Marion Island
Authors: Schoombie Stefan , Schoombie Janine
Published: September 2023

Pseudo-eggs are foreign objects, resembling eggs, found inside the nests of birds (Conover 1985) and have been recorded in several ground-nesting seabirds (Coulter 1980; Conover 1985; Mellink 2002; DeStefano et al. 2013; Wagner et al. 2013; Witteveen et al. 2015). They are more common among species that have larger clutches or multiple brood patches (Coulter 1980; Wagner et al. 2013) where pseudo-eggs are included to increase their clutch size (Coulter 1980; Conover 1985; Wagner et al. 2013; Witteveen et al. 2015). Albatrosses and petrels however, only lay one egg; rare two-egg clutches result from two females laying in the same nest, with one of them being an inexperienced breeder (Ryan et al. 2007). The occurrence of pseudo-eggs has only been reported for Laysan (Phoebastria immutabilis) and Black-footed Albatrosses (P. nigripes; Bartholomew & Howell 1964; Grant 1982). We did not find any record of albatrosses breeding in the Southern Ocean that exhibited pseudo-eggs.
The Implementation of User Centered Design Method in Developing UI/UX
Authors: Muktamar B Ahmad , Lumingkewas Cindy Sandra , Rofi'i Agus
Published: September 2023

The university has an academic information system called AIS, of which students are one of the main users. Based on the results of the questionnaire from previous research, it has been proven that the AIS display still needs development. This research develops the UI/UX of AIS to better suit the needs of users with the UCD method. Starting from planning agreements with parties related to research, determining the context by interviewing parties who agreed in the first stage, determining needs with questionnaires to users, using the System Usability Scale (SUS) method to determine the results, designing a prototype based on the results of the third step, and UI/UX evaluation, which is carried out using the same method when evaluating the UI/UX AIS running in the third stage to prove whether there has been a significant improvement or not. The evaluation results show that there is an increase in UI/UX, and based on statistical tests, there is a significant difference between the current UI/UX AIS and the UI/UX AIS being developed. In the process of evaluation and statistical tests, even though the SUS calculation results were still marginal, the two AIS questionnaire results proved to have significant differences. So that the results of this study can be accepted, improvements can be made in the future.
Teacher telling in the mathematics classroom: A microlevel study of the dynamics between general and contextualized knowledge
Authors: Chesnais Aurelie , Horoks Julie , Robert Aline , Rogalski Janine
Published: September 2023

In this article, we analyze moments of teacher telling (MTT) involving the exposition of new knowledge to students. We first specify the theoretical framework used for our analyses and describe our global methodology, focusing on teacher telling moments as taking part in the students’ mathematics learning. Then, we review the literature on this topic and develop a specific tool, called a “proximity,” to study MMTs in relation to whole-class scaffolding. Finally, we compare two high school teachers’ practices in teaching the same content — variation of functions for 10th grade students — to illustrate this new analytical lens. In the conclusion, we discuss our approach and develop several research perspectives.
Who am I, really? Reflections on developing professional identity as a Cégep teacher
Authors: McDonnell Maggie
Published: September 2023

In this MJE Forum, the author invites conversation on what it means to be a teacher in Quebec’s unique Cegep system. Cegep, positioned between the more structured secondary program and the more autonomous university experience, requires that its teachers grapple with what it means to be a Cegep teacher. Her own piece focuses on exploring her development as a teacher and how teacher identity is shaped by personal and professional relationships. Beyond professional development in workshops and continuing education, Cegep teachers engage in discussions, debates, and collaborations with our peers; ultimately, this community of practice is an essential element in the development of our teaching practice and our identity.
Lessons from the junk drawer: Possibilities for sustainability in art education
Authors: Stendel Jackie
Published: September 2023

From planetary warming and natural disasters to pollution and community unrest, the sensorium of the climate crisis pervades our daily life. Art education has the potential to help us better understand the sensory reality of the climate crisis. However, the materials used in artistic creation are ecologically unsustainable and therefore may hinder learner’s connection to ecology. Through exploring the metaphor of the junk drawer, the author positions materials as potential teachers and, subsequently, as important parts of meaningful teaching and learning. The article explores the pedagogical impacts of different art materials while arguing that sustainable materials can lead to eco-consciousness for educators and students.

 
Developing A New Model for Assessment of Heavy Vehicle-Pedestrian Collisions
Authors: Hoxha Gezim , Bixhaku Mevlan , Duraku Ramadan
Published: September 2023

The treatment and analysis of accidents involving heavy transport vehicles and pedestrians include the identification and treatment of a certain number of factors that may differ from the cases of passenger vehicle-pedestrian accidents. The aim of this paper is to develop a new model with better performance for speed estimation and reconstruction of accidents involving heavy vehicles and pedestrians. In a large number of cases during the research, it was observed that the experts used the same models for passenger vehicles as for transport vehicles. Likewise, a number of factors that have an impact on heavy vehicle accidents with pedestrians are not included as factors that have an impact on other accidents. The newly developed model, which has better performance than other models, can help experts in the case of analysis, speed determination, and reconstruction of accidents involving heavy vehicles and pedestrians. The model describes more than 94% of the most influential factors in the model (R2 = 0.945). This model will provide a novel way to examine crashes involving heavy vehicles and pedestrians, generating highly precise results for speed calculation which can be used to recreate the technical aspects of the accident. Additionally, it will help specialists in the field when preparing their expert opinion, specifically when heavy vehicles and pedestrians are involved, by providing a model which is different from the standard approach and yields more reliable outcomes.
Screen-Out Stones Activated with Mineral Binders and Used as Material for Earth Construction
Authors: Hydzik-Wiśniewska Joanna , Ostrowski Łukasz , Wilk Anna , Krajewski Adrian
Published: September 2023

The article presents the e valuation o f h ow suitable waste from the production of aggregates in quarries could be in earthwork using the example of screen-outs from Krosno sandstone. The waste, called screen-out, is characterised by an uncontrolled content of dust and clay fractions. Screen-outs have a relatively low bearing ratio (CBR not exceeding 20%) and a tendency to heave due to frost (SE <35). To check whether the geotechnical properties can be improved, mixtures with 2%, 5%, and 8% binders, such as lime, fly ash, and two road binders with lime, fly ash, and cement were prepared. The analysis was based on the results of the CBR and compressive strength tests. The use of mineral binders caused the value of the immediate CBR to increase compared to the screen-out itself from a dozen to as much as 50%. For a binder containing 20% Portland clinker, the CBR was about 60% after 4 days of saturation, while for a binder containing up to 50% Portland clinker, it was over 200%. The value of compressive strength after 28 days of maturing ranged from about 100 kPa to 1 MPa for all mixes tested. The lowest values were obtained for screen-outs activated with fly ash, and the highest for road binder with cement content of up to 50%.
An Assessment of The Effect of The Average Speed Enforcement Systems on Lithuanian Roads
Authors: Gavėnienė Laura , Čygas Donatas , Jateikienė Laura , Vorobjovas Viktoras , Jasiūnienė Vilma , Zarinš Atis
Published: September 2023

The speeding is a major road safety problem on the roads of Lithuania and many other countries. To reduce and control the speed of vehicles, engineering measures are installed on the roads of Lithuania and other countries – intelligent instantaneous and average speed enforcement systems, as well as many other engineering and structural speed reduction measures. The article presents good practices in the use of average speed enforcement systems, assessment of their effect on road safety. The article analyses the assessment results of the effect of the average speed enforcement systems installed on 25 sections of roads in Lithuania that have been operating for four years. Calculations of the effect factor of the installed average speed enforcement systems on road safety were performed using the before-and-after (B&A) method with a comparison group. Studies on the effect of application of speed control systems provide conditions for evaluating road safety, i.e., changes in road accidents linked to the effectiveness of implemented measures. The conclusions of the conducted study presented the calculations of the efficiency coefficients of the average speed enforcement systems on Lithuanian main and national roads. The analysis of the results of the conducted study allows stating that the installed average speed enforcement systems on 25 sections of Lithuanian roads increase overall road safety by 47%, reduce the number of collisions with animals by 80%, and the number of collisions with vehicles by 35%, as well as the number of other road accidents by 56%.
Some new results on intuitionistic fuzzy operators
Authors:   Department of Mathematics, Bir Bikram Memorial College, Bhattacharya Jaydip
Published: September 2023

The concept of intuitionistic fuzzy sets is becoming very popular day by day among mathematicians and researchers from other areas of science. It has been noticed that some operators have very interesting properties in Intuitionistic fuzzy sets. That is why these properties are investigated in this study. New findings on equality are obtained and proved.
TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling
Authors: Xiong Luyang , Zhevlakova Irina , West Xiaoxia Z. , Gao Detao , Murtazina Rakhylia , Horak Anthony , Brown J. Mark , Molokotina Iuliia , Podrez Eugene A. , Byzova Tatiana V.
Published: September 2023

The etiology of hair loss remains enigmatic, and current remedies remain inadequate. Transcriptome analysis of aging hair follicles uncovered changes in immune pathways, including Toll-like receptors (TLRs). Our findings demonstrate that the maintenance of hair follicle homeostasis and the regeneration capacity after damage depends on TLR2 in hair follicle stem cells (HFSCs). In healthy hair follicles, TLR2 is expressed in a cycle-dependent manner and governs HFSCs activation by countering inhibitory BMP signaling. Hair follicles in aging and obesity exhibit a decrease in both TLR2 and its endogenous ligand carboxyethylpyrrole (CEP), a metabolite of polyunsaturated fatty acids. Administration of CEP stimulates hair regeneration through a TLR2-dependent mechanism. These results establish a novel connection between TLR2-mediated innate immunity and HFSC activation, which is pivotal to hair follicle health and the prevention of hair loss and provide new avenues for therapeutic intervention.Hair follicle stem cells TLR2 is required for hair homeostasis and regeneration. While TLR2 stimulation by endogenous ligand promotes hair growth, reduction in TLR2 and its ligand in aging and obesity may diminish hair growth.
Double and triple thermodynamic mutant cycles reveal the basis for specific MsbA-lipid interactions
Authors: Lyu Jixing , Zhang Tianqi , Marty Michael T. , Clemmer David , Russell David , Laganowsky Arthur
Published: September 2023

Structural and functional studies of the ATP-binding cassette transporter MsbA have revealed two distinct lipopolysaccharide (LPS) binding sites: one located in the central cavity and the other at a membrane-facing, exterior site. Although these binding sites are known to be important for MsbA function, the thermodynamic basis for these specific MsbA-LPS interactions is not well understood. Here, we use native mass spectrometry to determine the thermodynamics of MsbA interacting with the LPS-precursor 3-deoxy-D-
manno
-oct-2-ulosonic acid (Kdo)
2
-lipid A (KDL). The binding of KDL is solely driven by entropy, despite the transporter adopting an inward-facing conformation or trapped in an outward-facing conformation with adenosine 5’-diphosphate and vanadate. Double and single mutant cycles reveal that pairwise residues engage KDL with a positive coupling energy, which stems from positive coupling entropy (as large as -100 kJ/mol at 298K) outweighing unfavorable coupling enthalpy. Our results provide new insight into how pairwise interactions can thermodynamically contribute to specific, high-affinity lipid binding in membrane proteins, which may have implications in the design of small molecules targeting specific lipid-protein interactions.
CESCProg: a compact prognostic model and nomogram for cervical cancer based on miRNA biomarkers
Authors: Muthamilselvan Sangeetha , Palaniappan Ashok
Published: September 2023

Cervical squamous cell carcinoma, more commonly cervical cancer, is the fourth common cancer among women worldwide with substantial burden of disease, and less-invasive, reliable and effective methods for its prognosis are necessary today. Micro-RNAs are increasingly recognized as viable alternative biomarkers for direct diagnosis and prognosis of disease conditions, including various cancers. In this work, we addressed the problem of systematically developing an miRNA-based nomogram for the reliable prognosis of cervical cancer. Towards this, we preprocessed public-domain miRNA -omics data from cervical cancer patients, and applied a cascade of filters in the following sequence: (i) differential expression criteria with respect to controls; (ii) significance with univariate survival analysis; (iii) passage through dimensionality reduction algorithms; and (iv) stepwise backward selection with multivariate Cox modeling. This workflow yielded a compact prognostic DEmiR signature of three miRNAs, namely hsa-miR-625-5p, hs-miR-95-3p, and hsa-miR-330-3p, which were used to construct a risk-score model for the classification of cervical cancer patients into high-risk and low-risk groups. The risk-score model was subjected to evaluation on an unseen test dataset, yielding a one-year AUROC of 0.84 and five-year AUROC of 0.71. The model was validated on an out-of-domain, external dataset yielding significantly worse prognosis for high-risk patients. The risk-score was combined with significant features of the clinical profile to establish a predictive prognostic nomogram. Both the miRNA-based risk score model and the integrated nomogram are freely available for academic and not-for-profit use at CESCProg, a web-app (https://apalania.shinyapps.io/cescprog).
Bariatric surgery before and after the SARS-CoV-2 pandemic: a comparative study of cases before the onset of the pandemic in a high volume academic center
Authors:   ,   Pontificia Universidad Católica de Chile. Facultad de Medicina, León Acuña Paula Blanca
Published: September 2023

Introduction: At the beginning of the pandemic, studies showed a higher risk of severe surgical complications and mortality among patients with perioperative SARS-CoV-2 infection, which led to the suspension of elective surgery. Confinement and lockdown measures were shown to be associated with weight gain and less access to medical and surgical care in patients with obesity, with negative health consequences. To evaluate the safety of Bariatric Surgery during the pandemic, we compared 30-day complications between patients who underwent Bariatric Surgery immediately before with those who underwent bariatric surgery during the opening phase of the pandemic. Methods: Observational analytical study of a non-concurrent cohort of patients who underwent Bariatric Surgery in 2 periods: pre-pandemic March 1 to December 31, 2019, and pandemic March 1 to December 31, 2020. Surgical complications were defined using the Clavien-Dindo classification. Results: Pre-pandemic and pandemic groups included 256 and 202 patients who underwent primary Bariatric Surgery, respectively. The mean age were 37.6 + 10.3 years. The overall complication rate during the first 30 days of discharge was 7.42%. No differences between groups were observed in severe complications (pre-pandemic 1.56% vs. pandemic 1.98%, p: 0.58). No mortality was reported. Overall 30-day readmission was 3.28% with no differences between groups. Conclusion: The findings of this study suggest that bariatric surgery can be successfully conducted during the pandemic, enabling patients with obesity to obtain a treatment that was delayed at the beginning of the pandemic due to safety concerns.
Impact of Tillage and Nitrogen Management Practices on Growth and Yield of Rabi Maize (Zea mays L.)
Authors: Jyosthna N. , Manjulatha G. , Mahesh N. , Shakher K. Chandra
Published: September 2023

A field experiment was conducted in sandy loam soils of Agricultural Research Station, Karimnagar during Rabi, 2022 in a split-plot design with three replications. Main plots includes three tillage practices viz., Zero tillage, Reduced tillage and Conventional tillage and sub plots includes three nitrogen levels viz., 75 %N, 100%N and 125%N. The results revealed that, maize cultivation under conventional tillage recorded significantly higher grain yield (8324 kg ha-1) which is statistically on par with reduced tillage treatment (7775 kg ha-1). In turn reduced tillage was statistically comparable to zero-tillage treatment (7353kg ha-1). Among different nitrogen levels examined, maize sown with 125% N application achieved significantly highest grain yield (8055 kg ha-1). This yield was statistically comparable to grain yield observed with 100% N application (7896 kg ha-1). While, significantly lowest grain yield (7501 kg ha-1) was recorded with 75% N application. Significantly highest grain yield in conventional tillage which is statistically on par with reduced tillage and among nitrogen levels, highest grain yield with 125%N which is on par with 100% N may attributed to increase in crop growth parameters viz., plant height, leaf area index and higher yield attributes viz., cob length and diameter, kernel rows number. The study concludes that maize cultivation with conventional tillage or reduced tillage results in higher grain yield. Concerning different nitrogen levels, higher grain and economic yield was obtained with 100% N application.
Perceptions of phc nurses: lh assessment during the nursing consultation with the chronically ill / Percepções dos enfermeiros da aps: avaliação do ls durante a consulta de enfermagem aos doentes crônicos
Authors: Nogueira Letícia Waldomiro , Pereira Luana dos Santos Dotta , Braga Cristiane Giffoni , Da Costa Ana Caroline , Vilella Débora Vitória Alexandrina Lisboa
Published: September 2023

Objetivo: explorar as percepções dos enfermeiros da Atenção Primária sobre a importância de avaliar o Letramento em Saúde, durante a consulta de enfermagem aos doentes crônicos. Método: abordagem qualitativa, descritivo, desenvolvido com dez enfermeiros das Estratégias de Saúde da Família de um município sul Mineiro. A coleta de dados ocorreu por meio da técnica de grupo focal, sob a análise de conteúdo Bardin. Resultado: através da análise do discurso dos participantes, pode-se observar as percepções e estratégias decorrentes do Letramento em Saúde na consulta de enfermagem aos doentes crônicos. Conclusão: os participantes demonstraram conhecimento sobre o Letramento em Saúde, conseguindo identificar fatores influenciadores, impacto gerado pelo nível de Letramento em Saúde, assim como os facilitadores e barreiras que afetam no desenvolvimento de atividades de enfermagem que visam melhorar o nível de Letramento em Saúde dos pacientes.
Who Should—and Can—Get Lecanemab, the New Alzheimer Disease Drug?
Authors: Rubin Rita
Published: September 2023

This Medical News story examines the complexity of determining who to treat with lecanemab, the new Alzheimer disease drug.
Genital and Perigenital “W”-Shaped Telangiectasias in Women With Limited Cutaneous Systemic Sclerosis
Authors: Dib Nicole , Isnard Camille , Mouthon Luc , Dupin Nicolas
Published: September 2023

This case report describes 3 patients with limited cutaneous systemic sclerosis who were found to have telangiectasias affecting the vulva and the inguinal folds.
Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials
Authors: Hansford Harrison J. , Cashin Aidan G. , Jones Matthew D. , Swanson Sonja A. , Islam Nazrul , Douglas Susan R. G. , Rizzo Rodrigo R. N. , Devonshire Jack J. , Williams Sam A. , Dahabreh Issa J. , Dickerman Barbra A. , Egger Matthias , Garcia-Albeniz Xabier , Golub Robert M. , Lodi Sara , Moreno-Betancur Margarita , Pearson Sallie-Anne , Schneeweiss Sebastian , Sterne Jonathan A. C. , Sharp Melissa K. , Stuart Elizabeth A. , Hernán Miguel A. , Lee Hopin , McAuley James H.
Published: September 2023

Importance

Observational (nonexperimental) studies that aim to emulate a randomized trial (ie, the target trial) are increasingly informing medical and policy decision-making, but it is unclear how these studies are reported in the literature. Consistent reporting is essential for quality appraisal, evidence synthesis, and translation of evidence to policy and practice.

Objective

To assess the reporting of observational studies that explicitly aimed to emulate a target trial.

Evidence Review

We searched Medline, Embase, PsycINFO, and Web of Science for observational studies published between March 2012 and October 2022 that explicitly aimed to emulate a target trial of a health or medical intervention. Two reviewers double-screened and -extracted data on study characteristics, key predefined components of the target trial protocol and its emulation (eligibility criteria, treatment strategies, treatment assignment, outcome[s], follow-up, causal contrast[s], and analysis plan), and other items related to the target trial emulation.

Findings

A total of 200 studies that explicitly aimed to emulate a target trial were included. These studies included 26 subfields of medicine, and 168 (84%) were published from January 2020 to October 2022. The aim to emulate a target trial was explicit in 70 study titles (35%). Forty-three studies (22%) reported use of a published reporting guideline (eg, Strengthening the Reporting of Observational Studies in Epidemiology). Eighty-five studies (43%) did not describe all key items of how the target trial was emulated and 113 (57%) did not describe the protocol of the target trial and its emulation.

Conclusions and Relevance

In this systematic review of 200 studies that explicitly aimed to emulate a target trial, reporting of how the target trial was emulated was inconsistent. A reporting guideline for studies explicitly aiming to emulate a target trial may improve the reporting of the target trial protocols and other aspects of these emulation attempts.
Transition to Schizophrenia Spectrum Disorder Following Emergency Department Visits Due to Substance Use With and Without Psychosis
Authors: Myran Daniel T. , Harrison Lyndsay D. , Pugliese Michael , Solmi Marco , Anderson Kelly K. , Fiedorowicz Jess G. , Perlman Christopher M. , Webber Colleen , Finkelstein Yaron , Tanuseputro Peter
Published: September 2023

Importance

Episodes of substance-induced psychosis are associated with increased risk of developing a schizophrenia spectrum disorder. However, there are limited data on the transition risk for substance use without psychosis.

Objectives

To quantify the risk of transition to schizophrenia spectrum disorder following an incident emergency department (ED) visit for (1) substance-induced psychosis and (2) substance use without psychosis and to explore factors associated with transition.

Design, Settings, and Participants

A population-based retrospective cohort study (January 2008 to March 2022) of all individuals, aged 14 to 65 years, in Ontario, Canada, with no history of a psychotic disorder. Individuals with incident ED visits for substance use with and without psychosis were compared with members of the general population.

Main Outcomes and Measures

Transition to schizophrenia spectrum disorder using a chart-validated algorithm. Associations between ED visits for substance use and subsequent transition were estimated using cause-specific hazard models.

Results

The study included 9 844 497 individuals, aged 14 to 65 years (mean [SD] age, 40.2 [14.7] years; 50.2% female) without a history of psychosis. There were 407 737 individuals with an incident ED visit for substance use, of which 13 784 (3.4%) ED visits were for substance-induced psychosis. Individuals with substance-induced psychosis were at a 163-fold (age- and sex-adjusted hazard ratio [aHR], 163.2; 95% CI, 156.1-170.5) increased risk of transitioning, relative to the general population (3-year risk, 18.5% vs 0.1%). Individuals with an ED visit for substance use without psychosis had a lower relative risk of transitioning (aHR, 9.8; 95% CI, 9.5-10.2; 3-year risk, 1.4%), but incurred more than 3 times the absolute number of transitions (9969 vs 3029). Cannabis use had the highest transition risk among visits with psychosis (aHR, 241.6; 95% CI, 225.5-258.9) and the third-highest risk among visits without psychosis (aHR, 14.3; 95% CI, 13.5-15.2). Younger age and male sex were associated with a higher risk of transition, and the risk of male sex was greater in younger compared with older individuals, particularly for cannabis use.

Conclusions and Relevance

The findings of this cohort study suggest that ED visits for substance use were associated with an increased risk of developing a schizophrenia spectrum disorder. Although substance-induced psychoses had a greater relative transition risk, substance use without psychosis was far more prevalent and resulted in a greater absolute number of transitions. Several factors were associated with higher transition risk, with implications for counseling and early intervention.
Workplace stressors and their association with hair cortisol concentrations among ready-made garment workers in Bangladesh: A cross-sectional study
Authors: Dreher Annegret , Yusuf Rita , Ashraf Hasan , Ahmed Syed A K Shifat , Gao Wei , Strümpell Christian , Loerbroks Adrian
Published: September 2023

Objectives

Psychosocial working conditions of ready-made garment (RMG) workers have been associated with poorer self-reported health outcomes. However, no such research has been done with respect to physiological markers that are considered to reflect stress. We consequently aimed to investigate associations of psychosocial working conditions with such a marker, that is, hair cortisol, among RMG workers in Bangladesh.

Methods

We conducted semi-structured face-to-face interviews in labor colonies in the Mirpur area, Dhaka, Bangladesh, in February and March 2021 with individuals identifying as garment workers. The interview inquired after various workplace stressors and resources (i.e., workplace support, workplace bullying, vertical trust, beneficial leadership, work–family conflict, and financial issues including savings, debts, financial obligations, and financial support). In addition, hair samples of 2 cm length were collected from participants. Hair cortisol concentrations (HCC) were determined based on liquid chromatography–tandem mass spectrometry (LC-MS/MS). Linear regression models were run to detect possible associations of workplace stressors and resources with HCC.

Results

In total, data of 576 participants were included in the analysis (71.9% female, mean age = 25.9 years). Mean HCC was 4.4 pg/mg (standard deviation = 2.1 pg/mg). The sole variable significantly associated with increased HCC was “having to keep your job to support your children or spouse financially” (β = 0.28 [95% confidence interval 0.02–0.55]).

Conclusions

The sole workplace stressor significantly associated with increased HCC was the necessity to keep one’s job to support children or spouse financially. This observation can, however, barely be disentangled from the fact that one has children/a spouse.
ALDH1A3 promotes invasion and metastasis in triple‐negative breast cancer by regulating the plasminogen activation pathway
Authors: Bharadwaj Alamelu G. , McLean Meghan E. , Dahn Margaret L. , Cahill Hannah F. , Wasson Marie‐Claire D. , Arun Raj Pranap , Walker Olivia L. , Cruickshank Brianne M. , Fernando Wasundara , Venkatesh Jaganathan , Barnes Penelope J. , Bethune Gillian , Knapp Gregory , Helyer Lucy K. , Giacomantonio Carman A. , Waisman David M. , Marcato Paola
Published: September 2023

Aldehyde dehydrogenase 1A3 (ALDH1A3) is a cancer stem cell marker that promotes metastasis. Triple‐negative breast cancer (TNBC) progression has been linked to ALDH1A3‐induced gene expression changes. To investigate the mechanism of ALDH1A3‐mediated breast cancer metastasis, we assessed the effect of ALDH1A3 on the expression of proteases and the regulators of proteases that degrade the extracellular matrix, a process that is essential for invasion and metastasis. This revealed that ALDH1A3 regulates the plasminogen activation pathway; it increased the levels and activity of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA). This resulted in a corresponding increase in the activity of serine protease plasmin, the enzymatic product of tPA and uPA. The ALDH1A3 product all‐trans‐retinoic acid similarly increased tPA and plasmin activity. The increased invasion of TNBC cells by ALDH1A3 was plasminogen‐dependent. In patient tumours, ALDH1A3 and tPA are co‐expressed and their combined expression correlated with the TNBC subtype, high tumour grade and recurrent metastatic disease. Knockdown of tPA in TNBC cells inhibited plasmin generation and lymph node metastasis. These results identify the ALDH1A3–tPA–plasmin axis as a key contributor to breast cancer progression.
Activity Space
Authors: Matthews Stephen , Kim Peter
Published: September 2023

Activity space research has an established tradition in geography, particularly in behavioral geography. Across many health and social behavioral areas of research fields, there is an increasing need to better understand place‐based exposures and how these influence individual‐level outcomes. In this context, an activity space perspective provides an opportunity to redefine how the relationships between people and places are examined. Technological developments in geospatial data collection and the leveraging of new forms of spatiotemporal data on human mobility have generated considerable interest in activity space concepts, measures, visualization, and analytical methods. Today, activity space research is a vibrant area driven by the need for theoretical development, an ever‐expanding range of applications, attention to methodological challenges, and the need for innovative approaches to handling new forms of activity space data.
High‐Speed Rail and Regional Development
Authors: Wang Jiaoe , Xiao Fan
Published: September 2023

The development of high‐speed rail (HSR) has transformed economic landscapes worldwide. Studies of HSR and regional development mainly consider the wider socioeconomic impacts of HSR in three main fields: transport impacts (also known as travel effects); spatial and socioeconomic impacts; and environmental impacts. Transport impact refers to changes in accessibility and connectivity, in addition to modal substitution. Spatial and socioeconomic impact include changes in socioeconomic landscapes at intraregional and interregional scales due to the impact of HSR on the smooth flow of associated factors and the widening of markets of many kinds. Environmental impacts include effects on local air pollution, energy consumption and climate change, noise disturbances, and land occupation.