bluuebunny/crossref_metadata_2025 huggingface dataset:
A study of a deterministic model for meningitis epidemic
Authors: Yaga Samaila Jackson , Saporu Funmilayo W. O.
Published: April 2024

Objectives

A compartmental deterministic model that allows immunity from two stages of infection and carriage, and disease induced death, is used in studying the dynamics of meningitis epidemic process, in a closed population. It allows for difference in the transmission rate of infection to a susceptible by a carrier and an infective. It is generalized to allow a proportion of those susceptible infected to progress directly to infectives in stage I.

Methods

Two models are used in this study; the generalized model when these proportions are greater than zero (called model 1) and a special case when the proportion is zero (called model 2). The threshold conditions for the spread of carrier and infectives in stage I are derived for both models. Sensitivity analysis is performed on the reproductive number derived from the next generation matrix. The case-carrier ratio profile for various parameters and threshold values are shown. So also, are the graphs of the total number ever infected as influenced by the odds in favor of a carrier over an infective, in transmitting an infection to a susceptible, and the proportion of those susceptible that can progress directly to the infected stage.

Results

The infection transmission rate, these odds in favor of a carrier, and the carrier conversion rate to an infective in stage I, are identified as key parameters that should be subject of attention for any control intervention strategy. The case-carrier ratio profiles provide evidence of a critical case-carrier ratio attained before the number of reported cases grow to an epidemic level. They also provide visual evidence of epidemiological context, in this case, epidemic incidence (in later part of dry season) and endemic incidence (during rainy season).

Conclusions

Results from the total proportion ever infected suggest that the special case (model 2) can adequately represent, in essence, the generalized model (model 1) for this study.
Laplace convolutions of weighted averages of arithmetical functions
Authors: Cantarini Marco , Gambini Alessandro , Zaccagnini Alessandro
Published: April 2024

LetG⁢(g;x):=∑n≤xg⁢(n){G(g;x):=\sum_{n\leq x}g(n)}be the summatory function of an arithmetical functiong⁢(n){g(n)}. In this paper, we prove that we can write weighted averages of an arbitrary fixed numberNof arithmetical functionsgj⁢(n),j∈{1,…,N}{g_{j}(n),\,j\in\{1,\dots,N\}}as an integral involving the convolution (in the sense of Laplace) ofGj⁢(x){G_{j}(x)},j∈{1,…,N}{j\in\{1,\dots,N\}}. Furthermore, we prove an identity that allows us to obtain known results about averages of arithmetical functions in a very simple and natural way, and overcome some technical limitations for some well-known problems.
Nef vector bundles on a hyperquadric with first Chern class two
Authors: Ohno Masahiro
Published: April 2024

We classify nef vector bundles on a smooth hyperquadric of dimension

≥
4

{\geq 4}

with first Chern class two
over an algebraically closed field of characteristic zero.
Simultaneous determination of lesinurad and febuxostat in commercial fixed-dose combinations using a greener normal-phase HPTLC method
Authors: Alam Prawez , Shakeel Faiyaz , Alshehri Sultan , Iqbal Muzaffar , Foudah Ahmed I. , Aljarba Tariq M. , Abdel Bar Fatma M. , Alqarni Mohammed H.
Published: April 2024

So far, no documented method for simultaneously analyzing lesinurad (LND) and febuxostat (FBX) has been reported for either traditional high-performance thin-layer chromatography (HPTLC) or a green HPTLC technique. In order to determine LND and FBX simultaneously in commercially available fixed-dose combo tablets, this study devised a normal-phase HPTLC method that is fast, sensitive, and green. The green eluents for the simultaneous analysis of LND and FBX were a mixture of ethyl acetate:ethanol:water at 70:20:10 (v/v/v) ratio. The new approach’s greenness was predicted utilizing four distinct greenness tools: the National Environmental Method Index, Analytical Eco-Scale, ChlorTox, and Analytical GREENness approaches, and the results revealed a significantly greener profile. The current method operated on a linear scale between 30 and 1,000 ng·band−1. It was confirmed that the current approach is sensitive, accurate, precise, robust, and green. The LND and FBX contents of commercially available tablet products A and B were found to be within the range of 100 ± 2%, indicating that the existing methodology for simultaneously determining LND and FBX in pharmaceutical combination products is applicable. The results of the current methodology indicated that LND and FBX could be consistently measured in pharmaceutical combination products simultaneously using the current approach.
On some inequalities concerning polynomials with restricted zeros
Authors: Bhat Aijaz , Bhat Tanveer , Rather N. A.
Published: April 2024

In this work we prove some new Bernstein-type inequalities for the polynomials with restricted zeros. Our results strengthen some recently proved Erdős–Lax and Turán-type inequalities by Kumar and others. We further extend the obtained results to the polar derivative of a polynomial.
High-order block RIP for nonconvex block-sparse compressed sensing
Authors: Huang Jianwen , Liu Xinling , Hou Jingyao , Wang Jianjun , Zhang Feng , Jia Jinping
Published: April 2024

This paper concentrates on the recovery of block-sparse signals, which are not only sparse but also nonzero elements are arrayed into some blocks (clusters) rather than being arbitrary distributed all over the vector, from linear measurements. We establish high-order sufficient conditions based on block RIP, which could ensure the exact recovery of every blocks-sparse signal in the noiseless case via mixedl2/lp{l_{2}/l_{p}}minimization method, and the stable and robust recovery in the case that signals are not accurately block-sparse in the presence of noise. Additionally, a lower bound on necessary number of random Gaussian measurements is gained for the condition to be true with overwhelming probability. Furthermore, a series of numerical experiments are conducted to demonstrate the performance of the mixedl2/lp{l_{2}/l_{p}}minimization. To the best of the authors’ knowledge, the recovery guarantees established in this paper are superior to those currently available.
Interoceptive bodily awareness in patients seeking pain relief with osteopathic manipulative treatment: an observational cohort pilot study
Authors: Emmet Danielle K. , Davis Glenn , Pierce-Talsma Stacey , Shubrook Jay H. , Mehling Wolf
Published: April 2024

Context

Interoceptive bodily awareness (IBA) is one's attentional focus on and relationship with comfortable and uncomfortable (e.g., pain) internal body sensations. Integrating IBA into research on osteopathic manipulative treatment (OMT) is growing, both as an outcome and predictor of treatment outcomes; however, it has yet to be studied in a clinical setting.

Objectives

We aimed to conduct a pilot study to measure IBA, with the Multidimensional Assessment of Interoceptive Awareness (MAIA), in patients seeking OMT for pain, and to test if OMT exposure may be associated with higher IBA as measured by the MAIA. The primary outcome was the change in MAIA scores, and the secondary outcomes were reduction in pain intensity, reduction in pain interference, and increase in participants’ perception of change post-OMT.

Methods

A convenience sample was recruited from individuals presenting for OMT appointments at a College of Osteopathic Medicine OMT teaching clinic. Participants were recruited into our single-arm observational cohort study (n=36), and categorized into one of two groups, OMT-naïve (n=19) or OMT-experienced (n=17), based on prior exposure to OMT. We measured MAIA scores and clinical pain-related outcomes prior to, immediately after, and at 1 and 3 weeks after a usual-care OMT session in the clinic. Covariates including experience with mind–body activities, non-OMT body work, and physical and emotional trauma were also collected to explore potential relationships. We utilized t tests to compare MAIA scores and pain outcomes between groups and across time points. Stepwise regression models were utilized to explore potential relationships with covariates.

Results

The OMT-experienced group scored higher on the MAIA scales “Not-worrying” (p=0.002) and “Trusting” (p=0.028) at baseline. There were no significant changes in the MAIA scores before and after the single OMT session. Analysis of secondary outcomes revealed that all pain outcomes significantly decreased post-OMT (p<0.05), with the largest relative improvements in the acute pain and OMT-naïve subgroups, with diminishing effects over time.

Conclusions

Assessing IBA with MAIA in a clinical OMT setting is feasible. There were significant positive correlations between OMT exposure and two of the eight MAIA scales. Future studies are justified to further explore this relationship.
A Transcultural Interpretation of Key Concepts in China-US Relations: Hegemony, Democracy, Individualism and Collectivism
Authors: Li Yali
Published: April 2024

China-US bilateral relations suffer from periodical setbacks and transcultural communication has a positive role to play in improving those relations. As the largest two economies in the world today, both China and the United States draw inspiration from different traditions and cultures, rendering it difficult for the two countries to see eye to eye with each other when it comes to the key concepts of hegemony, democracy, individualism, and collectivism. Etymological roots, historical traditions, and national experiences help explain political realities and theoretical frameworks concerning these key concepts. For hegemony, force is emphasized for its role in US dominance or authority while China condemns hegemonism. For democracy, the means of the normative right to vote is highlighted in the US while the ends of people’s needs and welfare are underscored in China. For individualism and collectivism, it is no longer viable to stand aloof and mind just one’s own business, as the world is shrinking into a global village with intertwined destinies. A transcultural interpretation of key concepts in China-US relations can help enhance mutual understanding and facilitate dialogue through exchange and communication, hence contributing to the improvement of bilateral ties.
Grammar, cohesion and the co-ordination of the “self” in a current psychotherapeutic technique
Authors: Butt David G. , Moore Alison R. , Henderson-Brooks Caroline , Khoo Kristin
Published: April 2024

This paper aims to show how concepts and analytical methods of systemic functional linguistics can work congruently with other human practices to improve outcomes for those undergoing the suffering around loss of meaning and the absence of purposeful, self-directed experience. Based on a two-decade collaboration between linguists and psychotherapists in Sydney, Australia, and using the tools of text linguistics as developed by Michael A. K. Halliday and Ruqaiya Hasan in systemic functional theory, the paper presents an indicative selection of intense exchanges between traumatized persons and therapists (centrally the experience of ‘Ruth’). The level by level linguistic descriptions of these exchanges offer opportunities for understanding how progress in the clinical interaction might be achieved. The descriptions can also be evaluated against the theoretical claims of psychotherapy in psychiatry – in particular, the emphasis of the Conversational Model of Psychotherapy developed in England and Australia by Robert Hobson and Russell Meares, whose characterization of disorders involves an emphasis on ‘co-ordination’ and ‘cohesion’ within frontal lobe activity of traumatized patients. In this way the paper also explores conceptual parallels and intellectual antecedents shared between the Conversational Model and Systemic Functional Linguistics, contributing to the broader intellectual history of the human sciences.
Crystal structure of 3,3′-dimethoxy-4,4′-oxy-di-benzaldehyde, C16H14O5
Authors: Huang Shiyin , Yin Minlei , Lin Yuxin , Yang Heyi , Chen Jie , Qiu Ting
Published: April 2024

C16H14O5, monoclinic, P21/c (no. 14), a = 11.1420(17) Å, b = 8.4700(12) Å, c = 15.429(2) Å, β = 104.624(4)°, V = 1408.9(4) Å3, Z = 4, R
gt(F) = 0.0513, wR
ref(F
2) = 0.1243, T = 296(2) K.
Fabrication of cathode electrodes based on activated carbon, reduced-graphene for hybrid capacitive deionization technology
Authors: Nam Pham Thi , Kieu Anh Vo Thi , Phuong Nguyen Thu , Thu Trang Nguyen Thi , Han Nguyen The , Dang Le Hai , Anh Nguyen Tuan , Lam Tran Dai , Thom Nguyen Thi
Published: April 2024

Recently, hybrid capacitive deionization (HCDI) has been a promising desalination technology because of its low cost and effective ion removal ability. The electrode material is an important factor to affect to desalination capacity of HCDI technology. In this study, the nanocomposite electrodes were fabricated successfully based on activated carbon and reduced-graphene oxide/cobalt oxide (rGO-Co3O4) and polymeric binders which were used as cathode electrodes for Hybrid capacitive deionization (HCDI) technology. The effect of polyvinyl alcohol (PVA) and polyvinylidene fluoride (PVDF) polymeric binders and the amount of rGO-Co3O4 on characteristic as well as specific capacitance of the nanocomposite electrodes were investigated. The nanocomposite electrode combined hydrophilic binder of PVA-based and 50 % rGO-Co3O4 has a specific capacitance of 15.3 mg/g in 200 ppm NaCl solution after 25 min at 1.2 V, which is 1.67 times higher than that of the AC-based electrode.
Stochastic processes and mean square calculus on fractal curves
Authors: Khalili Golmankhaneh Alireza , Welch Kerri , Serpa Cristina , Stamova Ivanka
Published: April 2024

In this paper, random and stochastic processes are defined on fractal curves. Fractal calculus is used to define the cumulative distribution function, probability density function, moments, variance,
and correlation function of stochastic processes on fractal curves. A new framework, which is a generalization of mean square calculus, is
formulated. The sequence of random variables on the fractal curve, fractal mean square continuity, mean square

F
α

{F^{\alpha}}

-derivative,
and fractal mean square integral are discussed. The mean square solution of a fractal stochastic equation is derived and plotted to illustrate the details.
A zebrafish xenotransplant model of anaplastic thyroid cancer to study tumor microenvironment and innate immune cell interactions in vivo
Authors: Michael Cassia , Mendonça-Gomes Juliana Moreira , DePaolo Clinton Walton , Di Cristofano Antonio , de Oliveira Sofia
Published: April 2024

Anaplastic thyroid cancer (ATC) is of the most aggressive thyroid cancer. While ATC is rare, it accounts for a disproportionately high number of thyroid cancer-related deaths. Here, we developed an ATC xenotransplant model in zebrafish larvae, where we can study tumorigenesis and therapeutic response in vivo. Using both mouse (T4888M) and human (C643)-derived fluorescently labeled ATC cell lines, we show these cell lines display different engraftment rates, mass volume, proliferation, cell death, angiogenic potential, and neutrophil and macrophage recruitment and infiltration. Next, using a PIP-FUCCI reporter to track proliferation in vivo, we observed cells in each phase of the cell cycle. Additionally, we performed long-term non-invasive intravital microscopy over 48 h to understand cellular dynamics in the tumor microenvironment at the single-cell level. Lastly, we tested two drug treatments, AZD2014 and a combination therapy of dabrafenib and trametinib, to show our model could be used as an effective screening platform for new therapeutic compounds for ATC. Altogether, we show that zebrafish xenotransplants make a great model to study thyroid carcinogenesis and the tumor microenvironment, while also being a suitable model to test new therapeutics in vivo.
PRACTICAL USAGE OF CROSS-CULTURAL TEXTS IN THE CLASSES OF UKRAINIAN AS A FOREIGN LANGUAGE
Authors: Denysiuk Nadia , Nazarevych Lesia , Babiak Zhanna
Published: April 2024

The article is devoted to a topical issue: the study of cross-cultural texts as the main communicative tool in Ukrainian language classes as a foreign language. The ideas presented in the article are illustrated by examples based on the experience of teaching Ukrainian as a foreign language at Ternopil Ivan Puluj National Technical University (TNTU). The analysis of modern researches and publications is carried out. The importance of considering the linguistic and cultural approach is emphasized, as well as the emotional component, choosing songs, phrases, colloquialisms, and thematic texts. Based on the lyrical song "Hutsulka Ksenia", the authors demonstrated how at the level of themes, images, and tokens itis possible to tell foreign communicators about mental features of Hutsuls, culture, nature, and folk instruments. A number of methodical developments on e-platforms are given: open4ukrainian.education/gutsulka-ksenya/;http://bit.ly/rizdvyanipisni-kolyadki, the benefits of working with online tools are revealed: Wizer.me (https://wizer.me/), Learningapps (https://learningapps.org), which are very important in distance learning languages. The objective of the article is to draw attention of teachers-practitioners to the need of selecting educational materials with consideration of the expediency and practical application of information; to focus on the development of communicative competence; to prove the relevance of a variety of tasks and examples; to share the experience of teaching the Ukrainian language among foreign students. The hermeneutic, communicative, cultural and other methods are applied in the research; the importance of visualization of pre-text and posttext exercises, questions, post-text comments is studied. The methodological basis of this research is the work of Anna Shvets “Theory and practice of teaching the Ukrainian language to foreign students of humanities: a monograph” (Shvets, 2019). The content of cross-cultural texts, which contribute to the formation of linguistic and local lore knowledge about Ukraine, and help foreign students adapt to Ukraine and be acquainted with its realities, is analyzed and described.
NATIONAL TRADITIONS IN SPIRITUAL DEVELOPMENT FUTURE TEACHERS
Authors: Klepar Maria
Published: April 2024

It was concluded that knowledge concerning spiritual achievements gained by young people during their studies should make stimulant active treatment of young Ukrainian to study specific in nature, truly accurate historical spiritual heritage of his people, rooted in folklore (folk art) and saved in any manifestation at the local level.The article analyzes the role of national traditions in the spiritual development of future teachers. The specific focus is placed on the problems of primary school. According to scientists, it is in the early school years that the worldview of the individual is formed, in particular the national identity.The upbringing of a versatile and harmonic personality of a petty in the new age Ukrainian school is one of the most important tasks at the present stage of society; in which enrichment of the child's spiritual world involves the formation of  creative potential and inner culture as well as spiritual unity of generations. The upbringing of young citizens should be aimedprimarily at developing their humanistic feelings, the formation of national and universal values. Therefore, the revival of folk song culture has great importance in the education of students of the new age Ukrainian school.The educational possibilities of Ukrainian folk songs were determined in the theoretical analysis. The necessity of directing the attention of the petty on the ideological and didactic nature of the folk song was described. That is important as the song folklore is a polysystemic means of personality formation, and it affects the spiritual, intellectual, emotional, and other spheres of a human being; morally and psychologically adjusts a person to work. The proper use of ethno –pedagogical tools ensures the esthetic development of students along with a high culture of perception of various arts. In conclusion, the knowledge of spiritual achievements gained by petty during their studies should stimulate an affirm attitude of them as young Ukrainians to study and research historical, spiritual heritage of their people, the roots of which are folklore (folk art) that is preserved in different manifestations at the local levels.
INTERCULTURAL COMMUNICATION AS A MEANS OF PERSONALITY FORMATION OF THE FUTURE TEACHER
Authors: Myskiv Iryna
Published: April 2024

The article is devoted to the research of the problem of intercultural communication as a means of the personality formation of the future teacher in the context of modern social factors. This problem is actualized by the fact that changes in the national education system are determined by global, social, domestic, regional and personal aspects.It requires radical changes both in the training of a new generation of professionals capable of understanding and real transformations in modern education at all stages, from preschool to higher educational institutions. The priority areas of educational tasks in terms of reforming and improving the training of future teachers at the present stage include: the formation of a person who realizes their belonging to the Ukrainian nation, accepts and appropriates its values, preserves and multiplies national culture and language; formation of socio-cultural competencies of future teachers, understanding of the importance and complexity of globalization and integration processes; nurturing national and civic values, understanding the difference between them and the role in the life of civilized society; formation of readiness to conduct interethnic and intercultural dialogue, adherence to the position of respect for traditions, culture, religion and language of the peoples of the world; building general didactic, developmental and educational competencies in order to achieve a high level of professional activity.Intercultural communication based on a broad analysis of research is interpreted as a functionally conditioned, communicative interaction of people, who are the carriers of different cultural communities in terms of their awareness of belonging to different geopolitical, continental, regional, religious, national, ethnic communities and social cultures. A special attention in the organization and implementation of intercultural communication is given to the humanities, which are part of the training of future teachers and have significant intercultural potential. They include foreign languages as a means of learning about the world, communication, cultural exchange, etc.The study claims that socio-cultural education and the organization of broad intercultural communication permeates the professional training of teachers and is aimed at developing the cultural, communicative, general pedagogical spheres of future teachers as socially significant actors, carriers and participants in the dialogue of cultures. Language skills, inthe broadest sense of the term, become an important competence in every person`s life, especially the one of a teacher who communicates with children and youth and should be a certain role model for their students. Creating conditions for mastering the language and its wide use in everyday life is an important and necessary task of modern education, whichshould be provided both at the theoretical and applied levels.
EVALUATION OF HEAT LOSSES IN A NONCONCENTRATED SOLAR THERMOELECTRIC GENERATOR WITH SPECTRALLY SELECTIVE ABSORBERS
Authors: Wang Jinglong , Lu Lin
Published: April 2024

Solar thermoelectric generator (STEG) has been widely studied in optical and thermal concentrating fields, and the spectral properties are mainly focused on the solar spectrum. However, limited attention has been paid to STEG without any concentrators and in the full spectral range. Therefore, in this work, a thermal-electrical coupled mathematical model for STEG systems is developed according to thermal resistance networks to investigate heat losses above the absorber and power generation performance. For the ideal selective absorber and emitter (ISAE) system, the main heat losses from the absorber occur due to radiative cooling to the sky as well as for the ideal broadband absorber (IBA) system, as opposed to convection and ambient radiative losses. These sky radiative cooling losses account for approximately 83.8% and 73.7% of the total heat losses, respectively. The total water vapor has the greatest impact on radiative cooling power compared to other heat losses, and the radiative cooling power for the IBA and ISAE modules decreases significantly, with a decline of nearly 62.93 W/m2 and 62.97 W/m2 from 129.6 W/m2 and 129.7 W/m2, respectively. Wind speed has the largest effect on convective heat loss, and for every 1 m/s increase in speed, the increment of convective loss is approximately constant with the average increment of 8.76 W/m2. Elevated ambient temperatures result in decreased heat loss across all forms. In light of its environmentally friendly characteristics, this paper offers recommendations on enhancing the system design of STEG aiming to minimize heat loss and enhance system performance.
COMPARISON OF AIR-COOLED AND SPRAY-COOLED HEAT TRANSFER PERFORMANCE WITH PHASE CHANGE MATERIAL COUPLED WITH MICROGROOVE FLAT PLATE HEAT PIPE
Authors: Wu Yanpeng , Wang Qianglong , Liu Qianlong , Guo Kaikai , Hao Zisu
Published: April 2024

This study investigates the thermal management performance of phase change material (PCM) coupled with a microgroove flat plate heat pipe under air cooling and spray cooling conditions. Different ratios of paraffin-lauric acid hybrid PCMs are prepared, and the thermophysical properties of the materials are optimal when the ratio of paraffin to lauric acid is 4:6. Composite PCMs are prepared by adding alumina nanoparticles, and the thermal conductivity is increased by 3.66 times when alumina particles with a mass fraction of 0.6% are added. Compared to air cooling, the spray cooling system demonstrates up to a 5.7% reduction in peak chip temperature. In the experimental range the spray
cooling system dissipates heat better for the 60 W heating power chip, while the air cooling system is more suitable for the 30 W heating power chip. In the air cooling system, the heat stored in the PCM accounts for up to 39.8% of the heating power. The maximum amount of heat stored in the PCM in the spray cooling system is 37.8% of the heating power. The heat storage capacity of the PCM in the spray cooling system is slightly lower than that of the air cooling system, but it still has a considerable heat storage capacity. This research can provide ideas for solving the heat dissipation problem of highdensity server chips in data centers.
High tech business entry in the pandemic era
Authors: Decker Ryan , Haltiwanger John
Published: April 2024

The COVID-19 pandemic and its aftermath have featured a surge in business entry (Decker and Haltiwanger 2024). A natural question is whether the elevated entry seen in recent years will have positive implications for aggregate productivity growth given the historically important role of business entry for productivity dynamics (Decker et al. 2014, Alon et al. 2018).
O ESTADO DO MAL-ESTAR: TERRENO FÉRTIL DA CORRUPÇÃO E DA NEGLIGENCIA SOCIAL
Authors: Santos Filho Bruno Freitas
Published: April 2024

O presente artigo objetivou discorrer a respeito dos efeitos desastrosos do capitalismo frente a da educação e a sociedade como um todo , refletindo acerca de seu papel  e a função metabólica de alienação e de exploração, ao longo do anos  no sentido de bestializar e domesticar os indivíduos para serem apenas uma peça da grande engrenagem do mercado de trabalho. A abordagem partiu de levantamento bibliográfico, cuja fonte de pesquisa se deu por meio de artigos acadêmicos da área, pesquisa documental com a utilização de anuários, estatísticas, tabelas e consultas em bases de dados confiáveis (scielo, portal capes, scholar google, science.gov). Como resultados e discussões percebe que a educação pública tem sido vendida e negligenciada e roubada dentro desse sistema alienante   e alienador.
Mycobacterium abscessus subsp. Bolletti-associated osteomyelitis of the lumbar vertebrae in immunocompetent patient
Authors: Anda Vīksna , Jānis Zeltiņš , Guntars Mauriņš , Vija Riekstiņa , Iveta Ozere
Published: April 2024

Introduction: Nontuberculous mycobacteria (NTM)-related Vertebral Osteomyelitis (VO) is a rare disease with challenging diagnosis and management. NTM-caused disease more often develops in vulnerable populations, affecting individuals who are immunocompromised or who have underlying health conditions. Methods: We report a case of Mycobacterium abscessus subsp. Bolletti-associated VO in a 60-year-old immunocompetent female patient. Results: The patient presented with chronic back pain and paresis of the legs. She underwent surgery - partial resection of L4 and L5 vertebral bodies, and vertebroplasty with allograft. Culture for Mycobacterium abscessus subspace Bolletti was positive from operation material, and treatment with multiagent antibacterial therapy was started. After 2 months of treatment, an asymptomatic m.psoas abscess was identified on control imaging. Repeated surgery with abscess drainage was applied, and treatment of M.abscessus infection was continued. After a 12-month course of treatment, the patient recovered successfully and could walk without support. During treatment, she experienced a lot of drug side effects including peripheral neuropathy. Conclusion: Sampling for Mycobacterium tuberculosis and NTM should be always considered in both, immunocompromised and immunocompetent patients presenting with clinical symptoms and imaging findings consistent with VO.
Western Blot in Mouse Brain Tissue for detecting pRab proteins v1
Authors: Erb madalynn.erb
Published: April 2024

Protocol for detecting pRab proteins in mouse brain tissue
Homogenate of A. cervicornis v1
Authors: Rosales Stephanie , M Palacio-Castro Ana
Published: April 2024

This protocol is to study disease in Acropora cervicornis by using a disease homogenate method. These methods are adapted from methods presented in Muller 2018 https://elifesciences.org/articles/35066.
Protocol for metagenomics sampling, storage, and sequencing of human stool v1
Authors: Pinto Federica , Segata Nicola
Published: April 2024

This SOP provides guidelines for optimal human fecal sample collection and conservation practice with the scope of fecal microbiota characterization by shotgun sequencing.
Changes in the enamel surface in patients with polymorphism of the VDR gene under the action of remineralizing composition and vitamin D
Authors: Tikhonova Svetlana N. , Kozlova Marina V. , Gorbatova Ekaterina A. , Evstafyeva Oksana L.
Published: April 2024

BACKGROUND: The leading role in the pathogenetic mechanism of caries development is the imbalance between the de and remineralization of hard tooth tissues. The combination of VDR alleles affects calcium-phosphate metabolism. In 65% of the human population, the structure of the VDR gene has a genetic polymorphism.
AIM: To study the effect of vitamin D and a remineralizing paste on the enamel surface structure in patients with genetic polymorphism of VDR gene receptors.
MATERIALS AND METHODS: In 18 individuals with a polymorphism index of the VDR A/A gene, a laboratory indicator of 25 (OH) vitamin D in the blood of 18.20±1.84 ng/ml, according to orthodontic indications, the retinated third molars in the lower jaw were removed. Then, the samples were lowered into three flasks of six pieces with 100 ml of artificial saliva. Containers with teeth were divided into groups: group 1, with a solution of artificial saliva only; group 2, an additional 1,000 IU of an aqueous solution of vitamin D; and group 3, tooth enamel was treated for 2 minutes with an electric toothbrush with a paste containing a remineralizing composition, immersed in artificial saliva with cholecalciferol 1,000 IU. The flasks were in the thermostat at a temperature of 37.4 C per day. In all samples, electron microscopy of the enamel contact surface at the level of the crown equator was performed using a Tescan Mira 3 LMU microscope (TESCAN, Czech Republic) with an Oxford X-MAX 5 energy dispersive X-ray detector (Oxford Instruments, United Kingdom) with analysis of local mineral composition.
RESULTS: In group 1, with electron microscopy of enamel, areas of increased mineralization alternated with areas of reduced density. The coefficient of the molar ratio Ca/P was 1.32±0.13, indicating the destruction of hydroxyapatites. In group 2 the intercrystalline pore space was filled with calcium and phosphate ions. In group 3, the enamel surface acquired a smooth homogeneous relief. An increase in the weight percentage of trace elements was observed, and the Ca/P ratio was 2.20±0.02, which indicated a phase of remineralization.
CONCLUSION: Patients with VDR gene polymorphism have a vitamin D deficiency in the blood serum. The trace element composition of the enamel surface is characterized by a phase of demineralization. Treatment with remineralizing paste and addition of cholecalciferol solution to artificial saliva changes the structure of hydroxyapatite and increases the caries-resistant properties of enamel.
The Content of Sciences about the Human Body as a Resource for the Formation of a System of Coordinates and Life Values of Future Teachers
Authors: Лапрун Т.А.
Published: April 2024

Рассматриваются некоторые возможности влияния наук об организме человека на формирование системы координат и ценностей, мировоззрения будущих педагогов. Подчеркиваются актуальность исторического сознания, исторической памяти, национального самосознания людей, а также ключевая роль воспитания и обучения молодого поколения в выборе верных ориентиров и целей для укрепления и прогрессивного развития Российского государства. Продемонстрирована возможность обращения к опыту предков, хранящемуся в древних источниках знаний на примере Библии. Отмечается важность изучения прошлого для понимания событий дня сегодняшнего, нахождения верных ориентиров в стремительно меняющемся мире. Делается заключение о необходимости поиска ресурсов управления процессами воспитания, обучения, формирования систем координат и ценностей подрастающего поколения преподавателями и педагогами независимо от их специализации.

Some possibilities of the influence of sciences about the human body on the formation of a system of coordinates and values, and the worldview of future teachers are considered. The relevance of historical consciousness, historical memory, national self-awareness of people is emphasized, as well as the key role of educating and training the younger generation in choosing the right guidelines and goals for strengthening and progressive development of the Russian state. The possibility of turning to the experience of ancestors stored in ancient sources of knowledge using the example of the Bible is demonstrated. The importance of studying the past is noted for understanding the events of today, finding the right guidelines in a rapidly changing world. A conclusion is made about the need to find resources for managing the processes of education, training, formation of coordinate systems and values of the younger generation by teachers and educators, regardless of their specialization.
Performing Race: Interrogating Gareth Hinds’ Graphic Novel Adaptation of Shakespeare’s Romeo & Juliet
Authors: Burton J. Katherine
Published: April 2024

Graphic novel adaptations, such as Gareths Hinds’ Romeo and Juliet, are a popular way to introduce audiences to Shakespeare, however focusing on a young audience obscures the fact that these are sophisticated interpretations integrating graphics and text, providing opportunities for adapters to reinterpret classic texts. The combination of visual and verbal resembles performance media (film and stage) and many of the analytical processes used for performance can also be applied to graphic novels. Recent studies of 20th and 21st century film and stage adaptations of Shakespeare critique the practices of directors and others involved in the selection process of actors of color for Shakespeare productions where race is not indicated in the original play text. These practices offer different approaches to, and understandings of, the semiotics of race in performance and the critiques identify issues associated with these various approaches. Applying these studies to graphic novel adaptations provides a more detailed understanding of the impact on audience reception of how adapters represent the characters and story lines of Shakespeare’s original texts. This paper interrogates Gareth Hind’s graphic novel adaptation and argues that, contrary to his stated intent of emphasizing universal themes, by racializing the Montagues and the Capulets, he introduces themes such as differential racialism and colorism into the story that problematizes readers’ interpretations of this classic Shakespeare text. This interrogation applies an understanding of the semiotics of race and performance in terms of non-traditional types of casting of characters, with a close reading of the interaction of graphics and text, comparing this reading to similar film and stage performances and how that reading may be interpreted/misinterpreted by readers/viewers.
Mechanical, Optical, and Thermal Properties of SnS2-Filled PVA Composites
Authors: Uğraşkan Volkan
Published: April 2024

The effects of tin disulfide (SnS2) addition on the mechanical, thermal, and optical characteristics of polyvinyl alcohol (PVA) were determined in this study. The solvent-casting approach was used to create composite films with varying SnS2 weight ratios. Mechanical testing revealed that the addition of SnS2 raised the tensile strength (TS) of the virgin PVA from 32.10 MPa to 47.50 MPa, while the elongation at break (EB) increased from 78.40% to 108.80%. Optical investigations revealed that PVA and SnS2 had intermolecular interactions. Furthermore, the contribution of SnS2 resulted in a drop in energy bandwidth from 5.310 eV to 4.821 eV. Thermal investigations revealed that PVA/SnS2 had greater stability than the virgin polymer. Given the data obtained, it was obtained that the addition of SnS2 simultaneously enhanced the mechanical, thermal, and optical properties of PVA.
Competitive Inhibition and Synergistic Effects of Nutraceutical and Metabolite Molecules on Anti-Acetylcholinesterase Activity
Authors: Girgin Munteha , Tarbiat Shirin , Işık Sevim , Kantarcı-carsıbası Nigar
Published: April 2024

The rapidly increasing prevalence of Alzheimer's disease (AD) poses a significant global public health threat. While medications such as Donepezil, Galantamine, and Rivastigmine are used, their serious side effects and limited healing fail to provide a definite cure. Consequently, combination therapies are being explored to enhance the efficacy of existing drugs. This study aims to evaluate the anti-acetylcholinesterase activities of previously identified nutraceutical and metabolite compounds, namely Queuine, Etoperidone, and Thiamine. Combined use of Queuine with Donepezil, Etoperidone, and Thiamine on acetylcholinesterase enzyme inhibition is also evaluated. The effects of the drug combinations on cell viability and acetylcholinesterase inhibition were investigated by using safe doses determined for each drug. The cytotoxic effect of drug combinations was investigated on the SH-SY5Y cell line using the RTCA method. All the individual or drug combinations were non-toxic to neuronal cells. Anti-acetylcholinesterase activities were estimated by Ellman’s method yielding the inhibition percentages as 70%, 61%, 45%, and 51% for Donepezil, Etoperidone, Queuine, and Thiamine, respectively. When drug combinations were analyzed, competitive inhibition resulted for Queuine+Donepezil and Queuine+Thiamine, the enzyme inhibition percentages being diminished to 47% and 21%, respectively. A significant synergistic effect was observed for Queuine+Etoperidone with the highest inhibition of 74%. This study provides the first evidence of the nutraceutical molecule Queuine's impact on acetylcholinesterase inhibition and the synergistic effect of Queuine and Etoperidone as a potent drug combination surpassing the effectiveness of Donepezil. Queuine and Etoperidone synergism may serve as a potential AD treatment by further in vivo validations.
Biosorption of Methyl Orange Dye in Single, Binary and Ternary System onto Gingerbread Plum Seed Shell Activated Carbon
Authors: Husaini Musa , Usman Bishir , Ibrahim Muhammad
Published: April 2024

The research investigated the potential of gingerbread plum seed shell activated to function as a biosorbent for eliminating methyl orange (MO) dye from water in various dye combinations, including single, binary, and ternary systems alongside methylene blue (MB) and Congo red (CR) dyes. The characteristics of the adsorbent were analyzed through techniques like Scanning Electron Microscopy, Fourier Transform Infrared spectroscopy, and pH point of zero charges. Batch adsorption tests were conducted to examine the adsorption processes' equilibrium behaviors, thermodynamics, and kinetics. The collected data were subjected to different isotherm and kinetics equations. The pseudo-second-order kinetics model provided the best fit for all the sorption systems, irrespective of composition differences, with higher rate constants observed for binary MO+MB= 0.031 g/mg/min system and lower for binary MO+CR= 0.028 g/mg/min and ternary MO+MB+CR= 0.029 g/mg/min systems compared to the single system MO= 0.030 g/mg/min. The maximum monolayer capacity of the adsorbent for methyl orange demonstrated synergistic interaction with the presence of methylene blue and antagonistic interaction with the presence of Congo red dye. The findings indicated that the adsorption processes varied based on the system's composition; they were all spontaneous (with Δ𝐺 values ranging from -1.146 to -10.415 kJ/mol) and exothermic (with Δ𝐻 values between -17.94 and -54.63 kJ/mol). Additionally, randomness decreased, as reflected by Δ𝑆 values of -054.43 and -382.62 J/K for the entire process.
Fatty Acid Composition, Antioxidant, and Enzyme Inhibition Activities of Cachrys Crassiloba (Boiss.) Meikle Fruit and Leaf Extracts
Authors: Büyükyıldırım Tuğsen , Bağcı Yavuz , Eruygur Nuraniye , Bakır Muhammed Raşit
Published: April 2024

The genus Cachrys L. (Apiaceae) is distributed in the Mediterranean region and contains 11 species. C. crassiloba (Boiss.) Meikle is a species that grows in Southwest and Western Anatolia. Considering the literature studies, there were not enough studies on C. crassiloba. In this study, fatty acid composition, total phenol/flavonoid contents, antioxidant and acetyl-butrylcholinesterase, tyrosinase, and α-glucosidase enzyme inhibition activities of n-hexane and ethanol extracts prepared from C. crassiloba fruits and leaves were investigated by spectrophotometric methods at different concentrations. When the results were evaluated, it was found that the hexane extract of C. crassiloba leaf (123.92 ± 4.62 GA mg/g extract) had the highest total phenol content, while the ethanol extract of C. crassiloba fruit (134.38 ± 0.98 QE mg/g extract) had the highest flavonoid content. C. crassiloba hexane and ethanol leaf extracts (IC50= 8.04 ± 1.31 µg/mL; 10.30 ± 3.15 µg/mL) showed good antioxidant activity com-pared to the ascorbic acid (IC50= 14.59 ± 1.96 µg/mL) in DPPH assay. C. crassiloba leaf ethanol extract (IC50= 17.38 ± 5.02 µg/mL) has the highest ABTS scavenging activity. C. crassiloba extracts have mod-erate cholinesterase inhibitory activity. C. crassiloba leaf ethanol extract (IC50= 196.65 ± 1.94 µg/mL) has good tyrosinase enzyme inhibition activity. C. crassiloba leaf hexane extract (36.35% ± 1.13) was found to have significant inhibitory activity against α-glucosidase. In conclusion, besides its antioxidant activity, C. crassiloba may be effective against neurodegenerative diseases and skin disorders such as hyperpigmentation and diabetes mellitus, but further phytochemical analysis studies are required.
Variação do potencial bioclimático em São Paulo frente ao cenário de mudanças climáticas
Authors: Guarda Emeli Lalesca Aparecida da , Kramer Daniela , Mizgier Martin Gabriel Ordenes
Published: April 2024

As preocupações globais com as condições de conforto térmico devido às mudanças climáticas têm se tornando pauta prioritária do século XXI. Esta pesquisa tem como objetivo a investigação da evolução climática, das estratégias bioclimáticas passivas de projeto, e das horas de conforto e desconforto, utilizando como base a série histórica climática da cidade de São Paulo. A metodologia consiste em elaboração do perfil climático da região de estudo utilizando a série histórica, e análise do potencial bioclimático por meio de estratégias bioclimáticas de projeto, utilizando o software AnalysisBIO. Os resultados apresentam tendências de variações nas amplitudes térmicas, podendo induzir ao estresse térmico por calor dos ocupantes, e as porcentagens de desconforto foram mais frequentes nos anos recentes. A estratégia de sombreamento apresenta maiores valores de horas requeridas em anos mais recentes, apresentando aumento em 3,1 pontos percentual em 2018 em relação a 1989. A investigação das estratégias bioclimáticas de forma evolutiva, apresenta recomendações que deveriam ser aplicadas hoje nos projetos para que as edificações garantam condições de conforto térmico em São Paulo nos próximos anos.
La Grande Muraille Verte en tant qu’imaginaire socio-technique
Authors: Pédarros Élie , Allouche Jeremy , Oma Matiwos Bekele , Duboz Priscilla , Diallo Amadou Hamath , Kassa Habtemariam , Laloi Chloé , Müller-Mahn Detlef , Soumahoro Kando Amédée , Bi Sylvestre Tchan , Yao Cyprien Yao
Published: April 2024

Le projet de la Grande Muraille Verte (GMV), lancé en 2007 par l’Union Africaine, est l’un des plus importants projets de transformation verte de l’Afrique. D’un mouvement environnemental panafricain à une mosaïque de modes de gestion et de mise en œuvre du projet à l’échelle locale en passant par son financement considérable de la part de la communauté internationale, la GMV est désormais considérée comme un « mégaprojet » étudié principalement selon les lignes de l’écologie politique et des études critiques sur le développement. Cependant, les nombreuses dissonances de perception entre les différents acteurs de la GMV à différentes échelles nous conduisent à proposer de considérer la GMV comme un imaginaire socio-technique, un outil permettant « l’élaboration de l’avenir ». Les débats conceptuels autour de la notion de « futur » permettent ainsi d’interroger la capacité de ce projet à intégrer des pratiques endogènes qui s’inscrivent dans une diversité de récits de mémoire environnementale collectivement construits. Considérer la GMV comme un imaginaire sociotechnique implique également de questionner le caractère panafricain de ce projet et de tenter de comprendre comment son expansion actuelle est effectivement négociée et réalisée.