bluuebunny/crossref_metadata_2025 huggingface dataset:
Neoadjuvant Three-Dimensional Conformal Radiotherapy for Resectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Randomized, Open-Label, Multicenter Controlled Study
Authors: Wei Xubiao , Jiang Yabo , Zhang Xiuping , Feng Shuang , Zhou Bin , Ye Xiaofei , Xing Hui , Xu Ying , Shi Jie , Guo Weixing , Zhou Dong , Zhang Hui , Sun Huichuan , Huang Cheng , Lu Congde , Zheng Yaxin , Meng Yan , Huang Bin , Cong Wenming , Lau Wan Yee , Cheng Shuqun
Published: July 2019

PURPOSE

To compare the survival outcomes of neoadjuvant three-dimensional conformal radiotherapy (RT) followed by hepatectomy with hepatectomy alone in patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT).

PATIENTS AND METHODS

A randomized, multicenter controlled study was conducted from January 2016 to December 2017 in patients with resectable HCC and PVTT. Patients were randomly assigned to receive neoadjuvant RT followed by hepatectomy (n = 82) or hepatectomy alone (n = 82). The modified Response Evaluation Criteria in Solid Tumors (mRECIST) guidelines were used to evaluate the therapeutic effects of RT. The primary end point was overall survival. The expression of interleukin-6 (IL-6) in patients’ serum before RT and in surgical specimens was correlated with response to RT.

RESULTS

In the neoadjuvant RT group, 17 patients (20.7%) had partial remission. The overall survival rates for the neoadjuvant RT group at 6, 12, 18, and 24 months were 89.0%, 75.2%, 43.9%, and 27.4%, respectively, compared with 81.7%, 43.1%, 16.7%, and 9.4% in the surgery-alone group ( P < .001). The corresponding disease-free survival rates were 56.9%, 33.0%, 20.3%, and 13.3% versus 42.1%, 14.9%, 5.0%, and 3.3% ( P < .001). On multivariable Cox regression analyses, neoadjuvant RT significantly reduced HCC-related mortality and HCC recurrence rates compared with surgery alone (hazard ratios, 0.35 [95% CI, 0.23 to 0.54; P < .001] and 0.45 [95% CI, 0.31 to 0.64; P < .001]). Increased expressions of IL-6 in pre-RT serum and tumor tissues were significantly associated with resistance to RT.

CONCLUSION

For patients with resectable HCC and PVTT, neoadjuvant RT provided significantly better postoperative survival outcomes than surgery alone. IL-6 may predict response to RT in these patients.
Epidural Analgesia During Childbirth and Postpartum Depressive Symptoms: A Population-Based Longitudinal Cohort Study
Authors: Eckerdal Patricia , Kollia Natasa , Karlsson Linnea , Skoog-Svanberg Agneta , Wikström Anna-Karin , Högberg Ulf , Skalkidou Alkistis
Published: July 2019

BACKGROUND:

Severe pain has been linked to depression, which raises the question of whether epidural analgesia (EDA) during childbirth is associated with a reduced risk of postpartum depression (PPD). This association has been explored previously, but the studies were restricted by small sample sizes and the inability to control for relevant confounders. This study aimed to investigate the association between the administration of EDA and the development of PPD after adjusting for sociodemographic, psychosocial, and obstetric variables.

METHODS:

Data were retrieved from the Biology, Affect, Stress, Imaging and Cognition (BASIC) project (2009–2017), a population-based longitudinal cohort study of pregnant women conducted at Uppsala University Hospital, Sweden. The outcome was PPD at 6 weeks postpartum, defined as a score of ≥12 points on the Edinburgh Postnatal Depression Scale (EPDS). Information was collected through medical records and self-reported web-based questionnaires during pregnancy and 6 weeks after childbirth. Only primiparous women with spontaneous start of childbirth were included (n = 1503). The association between EDA and PPD was examined in multivariable logistic regression models, adjusting for sociodemographic, psychosocial, and obstetric variables. Results are presented as odds ratios (ORs) with 95% confidence intervals (CIs).

RESULTS:

Of the 1503 women included in the analysis, 800 (53%) reported use of EDA during childbirth. PPD at 6 weeks postpartum was present in 193 (13%) women. EDA was not associated with higher odds of PPD at 6 weeks postpartum after adjusting for suspected confounders (age, fear of childbirth, antenatal depressive symptoms; adjusted OR [aOR] = 1.22; 95% CI, 0.87–1.72).

CONCLUSIONS:

EDA was not associated with the risk of PPD at 6 weeks postpartum after adjusting for sociodemographic, psychosocial, and obstetric variables. However, these findings do not preclude a potential association between PPD and childbirth pain or other aspects of EDA that were not assessed in this study.
Lipid Emulsion Containing High Amounts of n3 Fatty Acids (Omegaven) as Opposed to n6 Fatty Acids (Intralipid) Preserves Insulin Signaling and Glucose Uptake in Perfused Rat Hearts
Authors: Lou Phing-How , Lucchinetti Eliana , Hersberger Martin , Clanachan Alexander S. , Zaugg Michael
Published: July 2019

BACKGROUND:

It is currently unknown whether acute exposure to n3 fatty acid–containing fish oil–based lipid emulsion Omegaven as opposed to the n6 fatty acid–containing soybean oil–based lipid emulsion Intralipid is more favorable in terms of insulin signaling and glucose uptake in the intact beating heart.

METHODS:

Sprague–Dawley rat hearts were perfused in the working mode for 90 minutes in the presence of 11 mM glucose and 1.2 mM palmitate bound to albumin, the first 30 minutes without insulin followed by 60 minutes with insulin (50 mU/L). Hearts were randomly allocated to 100 µM Intralipid, 100 µM Omegaven, or no emulsion (insulin treatment alone) for 60 minutes. Glycolysis and glycogen synthesis were measured with the radioactive tracer [5-3H]glucose, and glucose uptake was calculated. Phosphorylation of protein phosphatase 2A (PP2A), protein kinase Akt, and phosphofructokinase (PFK)-2 was measured by immunoblotting. Glycolytic metabolites were determined by enzymatic assays. Mass spectrometry was used to establish acylcarnitine profiles. Nuclear factor κB (NFκB) nuclear translocation served as reactive oxygen species (ROS) biosensor.

RESULTS:

Insulin-mediated glucose uptake was decreased by Intralipid (4.9 ± 0.4 vs 3.7 ± 0.3 μmol/gram dry heart weight [gdw]·min; P = .047) due to both reduced glycolysis and glycogen synthesis. In contrast, Omegaven treatment did not affect insulin-mediated glycolysis or glycogen synthesis and thus preserved glucose uptake (5.1 ± 0.3 vs 4.9 ± 0.4 μmol/gdw·min; P = .94). While Intralipid did not affect PP2A phosphorylation status, Omegaven resulted in significantly enhanced tyrosine phosphorylation and inhibition of PP2A. This was accompanied by increased selective threonine phosphorylation of Akt and the downstream target PFK-2 at S483. PFK-1 activity was increased when compared with Intralipid as measured by the ratio of fructose 1,6-bisphosphate to fructose 6-phosphate (Omegaven 0.60 ± 0.11 versus Intralipid 0.47 ± 0.09; P = .023), consistent with increased formation of fructose 2,6-bisphosphate by PFK2, its main allosteric activator. Omegaven lead to accumulation of acylcarnitines and fostered a prooxidant response as evidenced by NFκB nuclear translocation and activation.

CONCLUSIONS:

Omegaven as opposed to Intralipid preserves glucose uptake via the PP2A–Akt–PFK pathway in intact beating hearts. n3 fatty acids decelerate β-oxidation causing accumulation of acylcarnitine species and a prooxidant response, which likely inhibits redox-sensitive PP2A and thus preserves insulin signaling and glucose uptake.
Decreasing Frontal Electroencephalogram Alpha Power and Increasing Sensitivity to Volatile Anesthetics Over 3 Surgeries Within 7 Months: A Case Report
Authors: Kaiser Heiko A. , Hirschi Trevor , Hartwich Volker , Stucki Monika , Rummel Christian , Reineke David , Hight Darren
Published: July 2019

Depth of anesthesia (DoA) monitors are widely used during general anesthesia to guide individualized dosing of hypnotics. Other than age and specific drugs, there are few reports on which comorbidities may influence the brain and the resultant electroencephalogram (EEG) of patients undergoing general anesthesia. We present a case of a patient undergoing 3 cardiac operations within 7 months with severe illness and comorbidity, leading to pronounced physical frailty and significant changes of frontal alpha power in the EEG and increased sensitivity to volatile anesthetics. These findings may have important clinical implications and should trigger further investigations on this topic.
Acclimation temperature changes spermatozoa flagella length relative to head size in brown trout
Authors: Fenkes Miriam , Fitzpatrick John L. , Shiels Holly A. , Nudds Robert L.
Published: July 2019

Temperature is a ubiquitous environmental factor affecting physiological processes of ectotherms. Due to the effects of climate change on global air and water temperatures, predicting the impacts of changes in environmental thermal conditions on ecosystems is becoming increasingly important. This is especially crucial for migratory fish, such as the ecologically and economically vital salmonids, because their complex life histories make them particularly vulnerable. Here, we addressed the question whether temperature affects the morphology of brown trout, Salmo trutta L. spermatozoa. The fertilising ability of spermatozoa is commonly attributed to their morphological dimensions, thus implying direct impacts on the reproductive success of the male producing the cells. We show that absolute lengths of spermatozoa are not affected by temperature, but spermatozoa from warm acclimated S. trutta males have longer flagella relative to their head size compared to their cold acclimated counterparts. This did not directly affect sperm swimming speed, although spermatozoa from warm acclimated males may have experienced a hydrodynamic advantage at warmer temperatures, as suggested by our calculations of drag based on head size and sperm swimming speed. The results presented here highlight the importance of increasing our knowledge of the effects of temperature on all aspects of salmonid reproduction in order to secure their continued abundance.
Lineage-specific determination of ring neuron circuitry in the central complex ofDrosophila
Authors: Bridi Jessika C. , Ludlow Zoe N. , Hirth Frank
Published: July 2019

The ellipsoid body (EB) of the Drosophila central complex mediates sensorimotor integration and action selection for adaptive behaviours. Insights into its physiological function are steadily accumulating, however the developmental origin and genetic specification have remained largely elusive. Here we identify two stem cells in the embryonic neuroectoderm as precursor cells of neuronal progeny that establish EB circuits in the adult brain. Genetic tracing of embryonic neuroblasts ppd5 and mosaic analysis with a repressible cell marker identified lineage-related progeny as Pox neuro (Poxn)-expressing EB ring neurons, R1-R4. During embryonic brain development, engrailed function is required for the initial formation of Poxn-expressing ppd5-derived progeny. Postembryonic determination of R1-R4 identity depends on lineage-specific Poxn function that separates neuronal subtypes of ppd5-derived progeny into hemi-lineages with projections either terminating in the EB ring neuropil or the superior protocerebrum (SP). Poxn knockdown in ppd5-derived progeny results in identity transformation of engrailed-expressing hemi-lineages from SP to EB-specific circuits. In contrast, lineage-specific knockdown of engrailed leads to reduced numbers of Poxn-expressing ring neurons. These findings establish neuroblasts ppd5-derived ring neurons as lineage-related sister cells that require engrailed and Poxn function for the proper formation of EB circuitry in the adult central complex of Drosophila.
Toxicity of the hydroalcoholic extracts of fruit leaves from the Peruvian Amazon in Artemia salina
Authors: Sandoval Vergara Ana , Ismiño Riquelme Armando
Published: July 2019

Background: Medicinal plants have been used since ancient times, receiving interest in their healing potential because of their active components. The Amazon rainforest in the east of Peru has great diversity of flora, especially monocotyledons (Cocos nucifera, Mauritia flexuosa and Coffea spp.) and dicotyledons (Theobroma cacao L. and Musa spp. The toxicity of the hydroalcoholic extract of plant leaves from the Peruvian Amazon in Artemia salina was evaluated in this study.

Methods: The leaves of the plants Cocos nucifera, Mauritia flexuosa, Theobroma cacao L., Coffea sp, and Musa sp were collected in the district of Cacatachi, San Martín. Phytochemical analysis of the leaves was carried out to identify their active components. The eggs of Artemia salina were provided by the Department of Animal Physiology of Universidad Nacional de Trujillo. The hydro-alcoholic extraction was carried out via the maceration method using 300 g of leaves and 500 mL of 96% ethanol for 15 days in agitation. The solutions were taken to a vertical rotavapor to obtain dry extracts and concentrations of 10, 100 and 1000 μL/ml were prepared. To test toxicity, 10 larvae were given the extract for each plant species and concentration in triplicate. The CL50 toxicity of Artemia salina samples was classified as: ˃ 1000 μL/ml (non-toxic), 500˂CL50 ≤ 1000 (low toxicity), 100˂CL50 ≤ 500 (moderate toxicity), CL50˂100 (high toxicity).

Results: It was observed that Mauritia flexuosa and Musa sp. at concentrations of 10, 100 and 1000 μL/ml have high, medium and low toxicity, respectively. However, only low toxicity was observed in Cocos nucifera, Theobroma cacao L. and Coffea sp.

Conclusions: It can be concluded that the obtained results are in accordance with other studies that examined different extracts, indicating that if a sample is non-toxic to Artemia salina, then its effects will also be similar in humans.
Consensus Ad Idem: A Plea for Objectivity in Telephonic Contracts
Authors: Kumar D Ganesh , Gudinho Akshay Douglas
Published: July 2019

Consensus Ad Idem, legally defined as „meeting of minds‟, at the time of the formation of a contract, warrants a cardinal jurisprudential question which transcends its mere literal meaning. In Indian Contract Law, the trend has followed the test of objectivity, whereby it is not the actual intent of the party or parties that enter into the contract that is the subject of judicial evaluation, but it is what a reasonable man would deliberate in the peculiar circumstances of the case. However, the evaluation of telephonic conversations merit intrinsic jurisprudential insight. While applying the objective test, the questions that arise are - is there legal certainty of assent to a contract over telephonic conversations i.e. whether there is free consent. Do the parties have the capacity to contract over telephone? What are the liabilities of the telephone operator and his legal bond to the contract between two or more contracting parties? Does it amount to violation of the fundamental rights to freedom of speech and expression and the right to privacy? The authors attempt to provide an objective analysis of communication in contracts over telephonic means and the constitutional environment embedded therein. To this end, a plea for due diligence prior to the formation of telephonic contracts shall be made in order to bring objectivity to the judicial evaluation of telephonic contracts.
Comparative Analysis of Cyber Stalking Legislations in UK, US and India
Authors: Stephen Arunbaby
Published: July 2019

The Internet, with its vast connectivity and ample resources, provides an easy platform for committing crimes. Cyber stalking is one such offence, which has grown in the last two decades with the advent of cheap and fast internet connectivity. The Internet provides various means by which cyber stalking can occur. The lack of boundaries on the internet creates more risk for the users and as more and more people start using internet, the scope and complexity of this problem will only increase. More and more states are passing exclusive statutes for tackling Cyber Stalking, believing that their offline stalking statutes are not enough to handle different aspects of this issue. This paper analyses the different legislations passed across the world to tackle cyber stalking. With stalking itself being a comparatively fresh offence in India, it has been a late entry into the field of cyber stalking, with the first provision being made in 2013, in the form of Section 354 D of the Indian Penal Code. The article examines the shortfalls of this provision and the ways in which they can be tackled.
Centrotrade Minerals & Metal Inc. v. Hindustan Copper Ltd
Authors: Pathak Varun
Published: July 2019

Case Comment
Non-Conventional Copyright: Do New and Atypical Works Deserve Protection?
Authors: Chakraborty Avishek
Published: July 2019

Enrico Bonadio and Nicola Lucchi (eds.)
Ouster Clause: Legislative Blaze and Judicial Phoenix
Authors: S A Sandhya Ram
Published: July 2019

If constitutionalism denotes obedience to the

Constitution, the scheme for enforcement of obedience

and invalidation of disobedience should be found in the

Constitution itself. It is important that this scheme be

clear and the task of enforcement be vested in a

constitutional body. In such a situation, the question of

custodianship i.e., who will ensure the rule of

constitutionalism assumes prime importance, as any

ambiguity regarding the same will result in conflicts

uncalled for between legislature and judiciary. This

conflict intensifies when judiciary determines the

constitutionality of the legislations and the legislature

defends by placing it in the „ouster clauses‟ within the

Constitution to exclude the judicial determination.

Judiciary counters by nullifying the legislative attempts

through innovative interpretation. An attempt is made to

study Article 31 B, the most prominent ouster clause in

the Constitution of India barring judicial review of

legislations and how the Indian judiciary retaliated to

such legislative attempts and effectively curbed them. The

study outlines the historical reasons which necessitated

the insertion of Article 31 B in the Constitution and

analyses the myriad implications of such an ouster clause

within the Constitution. The constitutional basis of

judicial review is studied to audit the justifiability of the

open ended Ninth Schedule along with Article 31 B. A

comparison between Article 31 B and the other ouster clauses namely Articles 31 A and 31 C is also made,

bringing out the effect and scope of Article 31 B. The

study covers a critical survey of judicial pronouncements

from 1951 to 2007.
Recognition of the Rights of the Victims of Climate Change under Public International Law: A Study
Authors: Sengupta Piyali
Published: July 2019

In recent years, climate change is emerging as a major

environmental disaster. The impact of such disasters has

been the rise in global temperature and flooding of coastal

zone communities, frequent droughts and disruptions in

rainfall pattern. This has resulted in the increase in the

number of environmental refugees. Climate change

disasters constitute a major reason for displacement of

population than war and persecution. Climate induced

migration is a highly complex issue. The status of climate

refugees is not recognized in the international framework.

The non recognition of these victims in international and

national legislations has not only deprived them of their

basic human rights but has also raised crucial questions

relating to their existence and identity. This paper tries to

bring out the lacunae in the present policy and legal

framework relating to environmental refugees with

reference to the non-refoulement principle. Further, the

paper emphasizes on the need to include climate refugees

under the term „refugee‟ as laid down in the United

Nations Convention relating to the Status of Refugees,

1951and provides suggestions for improving the

condition and protection of this hitherto neglected

population.
Implementing Cultural Diversity Within and Outside the European Union: A Test for the Delineation of Competences in Cultural Matters?
Authors: Laura-Maria Crăciunean
Published: July 2019

The purpose of this paper is to evaluate the European Union’s (EU) involvement in the protection of cultural diversity, both within and outside the EU, after the entering into force of the Lisbon Treaty, in 2009, and the adoption of the UNESCO Convention of 2005. The author examines whether this involvement can be depicted in concrete measures aiming at the effective internal and external implementation of the provisions of the UNESCO Convention of 2005. The author further seeks to analyse whether the entailed consequences of EU’s actions, including the erosion of the Member State's competences in the cultural field, was translated in concrete measures or if it still remains at the political discourse level.
Corporate Guarantee: Computation of Guarantee Fees at Arm’s Length Price
Authors: Vinti Agrawal
Published: July 2019

The most recent controversy surrounding Indian tax courts, pertains to the issue of international transactions with respect to intra-group financing. It includes short as well as long term borrowing and lending, guarantees etc. The debate centres around transfer pricing (herein after referred to 'TP') provisions and how the computation of arm’s length price is to be done. The article has focussed on one aspect of intra group financing, that is, the provision of corporate guarantee. The paper first describes the meaning of guarantee and then highlights various provisions relating to corporate guarantee, under the Companies Act, 2013 and the Foreign Exchange Management Act, 1999. The article then describes various legislative provisions relating to the transfer pricing issue and how guarantees fit into such provisions. It is ambiguous, as courts have not provided for a settled principle, in this regard. The author, thus, highlights various approaches the Indian tax courts have adopted when the issue of corporate guarantee came before them. The paper provides an answer to the issue of whether the guarantee fee can be computed at arm’s length price, using compared uncontrolled price as the method for computation. The author concludes by stating that while the courts have attempted to resolve these ambiguities, there is still scope for further reform.
Case Comment: Devidas Ramachandra Tuljapurkar V. State of Maharashtra
Authors: Shardha Rajam
Published: July 2019

On May 8 2008,Maqbool Fida Hussein, was acquitted by the Delhi High Court, in what was considered to be a landmark judgment on obscenity. The artist had painted ‘Bharatmata’ in the nude and had at various instances in the past, painted Hindu goddesses in obscene postures. The Delhi High Court held that the aesthetics of the painting and the social message it carried, far outweighed the ‘obscenity’ in it. The Bench believed that art ought not to be chained by anti-obscenity laws, if it is intended for the welfare of society and aimed to convey a social message and not the sexual arousal of the audience
Branch-and-Bound for Bi-objective Integer Programming
Authors: Parragh Sophie N. , Tricoire Fabien
Published: July 2019

In bi-objective integer optimization the optimal result corresponds to a set of nondominated solutions. We propose a generic bi-objective branch-and-bound algorithm that uses a problem-independent branching rule exploiting available integer solutions and takes advantage of integer objective coefficients. The developed algorithm is applied to bi-objective facility location problems and the bi-objective set covering problem, as well as to the bi-objective team orienteering problem with time windows. In the latter case, lower bound sets are computed by means of column generation. Comparison with state-of-the-art exact algorithms shows the effectiveness of the proposed branch-and-bound algorithm.
Filtering Algorithms for Biobjective Mixed Binary Linear Optimization Problems with a Multiple-Choice Constraint
Authors: Jornada Daniel , Leon V. Jorge
Published: July 2019

This paper deals with a class of biobjective mixed binary linear programs having a multiple-choice constraint, which are found in applications such as Pareto set–reduction problems, single-supplier selection, and investment decisions, among others. Two objective space–search algorithms are presented. The first algorithm, termed line search and linear programming filtering, is a two-phase procedure. Phase 1 searches for supported Pareto outcomes using the parametric weighted sum method, and Phase 2 searches for unsupported Pareto outcomes by solving a sequence of auxiliary mixed binary linear programs. An effective linear programming filtering procedure excludes any previous outcomes found to be dominated. The second algorithm, termed linear programming decomposition and filtering, decomposes the mixed binary problem by iteratively fixing binary variables and uses the linear programming filtering procedure to prune out any dominated outcomes. Computational experiments show the effectiveness of the linear programming filtering and suggest that both algorithms run faster than existing general-purpose objective space–search procedures.
A Branch-and-Cut Approach for the Weighted Target Set Selection Problem on Social Networks
Authors: Raghavan S. , Zhang Rui
Published: July 2019

The study of viral marketing strategies on social networks has become an area of significant research interest. In this setting, we consider a combinatorial optimization problem, referred to as the weighted target set selection (WTSS) problem. Earlier research has focused on approximation algorithms for the unweighted case of the problem, which is known to be NP-hard. Motivated by the desire to develop a better understanding of the fundamental problems in social network analytics, we seek to develop mathematical programming approaches to solve the WTSS problem exactly. We build upon a tight and compact extended formulation for the WTSS problem on trees described in a companion paper and show that it is also a tight and compact extended formulation for directed acyclic graphs (DAGs). On the basis of the observation that the influence propagation network in any arbitrary graph is acyclic, we add an exponential set of inequalities that enforce this condition and show how to apply the extended formulation for DAGs to arbitrary graphs. Using this idea, we develop and implement a branch-and-cut approach to solve the WTSS problem on arbitrary graphs. Our computational experience on a test-bed of 180 real-world graph instances (with up to approximately 155,000 nodes and 327,000 edges) demonstrates the quality and efficacy of our solution approach. The branch-and-cut approach finds solutions that are on average 0.90% from optimality and solves 60 of the 180 instances to optimality. On the other hand, the best heuristic solutions generated are on average 5.46 times worse than the solutions generated by the branch-and-cut approach.
Personalized Mobile Targeting with User Engagement Stages: Combining a Structural Hidden Markov Model and Field Experiment
Authors: Zhang Yingjie , Li Beibei , Luo Xueming , Wang Xiaoyi
Published: July 2019

Low engagement rates and high attrition rates have been formidable challenges to mobile apps and their long-term success. To date, little is known about how companies can scientifically detect user engagement stages and optimize corresponding personalized-targeting promotion strategies to improve business revenues. This paper proposes a new structural forward-looking hidden Markov model as combined with a randomized field experiment on app notification promotions. Our model can recover consumer latent engagement stages by accounting for both the time-varying nature of users’ engagement and their forward-looking consumption behavior. The structural estimates from the FHMM with the field-experimental data enable us to identify heterogeneity in the treatment effects. Additionally, we simulate and optimize the revenues of different personalized-targeting promotion strategies with the structural estimates. Personalized dynamic engagement-based targeting based on the FHMM can generate substantially higher revenues than the experience-based targeting strategy applied by current industry practices and targeting strategies based on alternative customer segmentation models. Overall, the novel feature of our paper is its proposal of a new personalized-targeting approach combining the FHMM with a field experiment to tackle the challenge of low engagement with mobile apps.
OM Forum—Challenges and Strategies in Managing Nonprofit Operations: An Operations Management Perspective
Authors: Berenguer Gemma , Shen Zuo-Jun (Max)
Published: July 2019

The operations management (OM) community is paying increasing attention to the analysis of nonprofit operations. However, what is it about this type of operation that makes it particularly interesting to OM scholars? We address this question by studying the objectives, actors, and main activities of nonprofit operations and the most common challenges they face. In addition, we suggest tactical and operational strategies to address these challenges by considering works in the for-profit sector and in different applied areas. The ultimate goal of this paper is to inspire and stimulate OM researchers to develop significant theoretical and empirical models in this novel stream of literature.
O dândi dos pampas
Authors: Casaroto Filho Cesar Marcos
Published: July 2019

No presente artigo, objetivo definir o que denomino dândi dos pampas, o artista-intelectual que, vivendo como obra de arte, por meio das suas payadas resiste ao espírito do colonialismo. Sem negar as suas origens crioulas, o dândi dos pampas se revolta contra o patronato ao sustentar a sua ética em versos. Ao estetizar a existência, o dândi dos pampas denuncia os abusos históricos sofridos pela América Latina. Para dar forma ao dândi dos pampas analisarei “Coplas del payador perseguido”, de Atahualpa Yupanqui e “Payada”, de Jayme Caetano Braun.
FLORISMUNDO PERIQUITO: A DESCOBERTA DE UM CONTO GOIANO
Authors: De Campos Ionice Barbosa
Published: July 2019

Faremos aqui uma breve análise do conto que dá título ao livro de José Godoy Garcia, “Florismundo Periquito”, a fim de mostrar o que a prosa godoyana tem para nos oferecer no que concerne à reflexão sobre o processo migratório que se encontra na literatura produzida em Goiás e mostrar como esse espaço expulsa e, ao mesmo tempo acolhe, seus transeuntes. Os personagens dessa narrativa, sempre instalados nas margens sociais, chamam nossa atenção para a discussão de uma teoria pautada em filósofos como Foucault e Deleuze, que tematizam esse assunto em suas obras, além, é claro, de enviesar a discussão para a representação de uma estética que nos permite verificar como os deslocamentos humanos estão presentes e influentes nas vidas dos personagens, com maior ou menor intensidade, mas nunca deixando o espaço em branco, uma vez que está sempre preenchido por uma identidade pessoal e/ou social.
VALDOMIRO SILVEIRA E AFONSO ARINOS – ENCONTRANDO A VOZ DO SERTÃO
Authors: Vazquez Gustavo Krieger
Published: July 2019

Desde os primórdios do Regionalismo, seus autores buscaram retratar através de maneiras diversas as elusivas vozes do sertão. No fim do século XIX e início do século XX, dois autores, Afonso Arinos e Valdomiro Silveira, escreveram contos usando mais de uma forma discursiva: uma narração híbrida, em que narrador e personagens mantém o mesmo nível dialetal; e uma transcrição ortográfica para os discursos das personagens – formas essas que, nos anos subsequentes, encontraram fruição sob a pena de outros autores.
O PROCESSO HISTÓRICO DE OCUPAÇÃO DO PARQUE JOÃO PAULO II E AS POLÍTICAS PÚBLICAS ADOTADAS PARA A REDUÇÃO DO RISCO DE DESASTRES
Authors: Lopes Talita Santiago , Teixeira Daniela Rocha , Leitão Francisco Luiz Guimarães , Leitão Gerônimo Emilio Almeida
Published: July 2019

Este trabalho pretendeu compreender o processo de urbanização da comunidade João Paulo II e quais as políticas públicas adotadas para a redução do risco de desastres e promoção de uma melhor qualidade de vida para os moradores. A pesquisa baseou- se na contextualização histórica da ocupação da favela através de sites que contém periódicos científicos, reportagens, planos e livros sobre o processo histórico de formação dos bairros e favelas do município do Rio de Janeiro. Sites oficiais do governo foram utilizados para obtenção de dados demográficos e econômicos. Uma pesquisa de campo foi realizada e informações levantadas junto aos moradores e a Defesa Civil municipal. O site GEOPEA foi a base de dados consultada para obtenção dos mapas que delimitam as áreas de risco geológico. A comunidade contou ao longo das últimas décadas com programas de urbanização e habitação implantados, assim como algumas obras de contenção de encostas e projetos de cunho socioambiental. A participação da própria comunidade no processo deve ser priorizada para dar legitimidade às ações, garantir a eficácia e evitar o estabelecimento de novos conflitos. Um adequado planejamento das áreas suscetíveis a desastres é necessário para que o risco seja mitigado, na medida do possível. Palavras Chave: Comunidades. Favelas. Risco. Desastres.
MEMÓRIAS DE PROFESSORAS: A ESCOLHA DA PROFISSÃO DOCENTE
Authors: Miliorini Layza Karla , Dudeque Pianovski Vieira Alboni Marisa
Published: July 2019

O artigo objetivou descrever e interpretar a trajetória de vida profissional das professoras participantes de um Programa de Formação Continuada oferecido por um grupo de pesquisadores de uma instituição privada de educação superior, durante o ano de 2017, na cidade de Curitiba, Paraná, para professoras do ensino fundamental I. A escrita do memorial e a realização de entrevistas semiestruturadas, foram analisadas por meio da fenomenologia hermenêutica, uma vez que esta não apenas descreve e analisa as vozes, as falas e a linguagem do sujeito, mas interpreta o que este meio comunica. Os dados revelam que as professoras têm grande satisfação com a profissão mesmo diante das dificuldades e exigências que acompanham a docência.
O ENSINO DE HISTÓRIA E A BNCC: LIVROS DIDÁTICOS SOB UMA ANÁLISE COMPARATIVA
Authors: Tamanini Paulo Augusto , Noronha Vanusa Maria Gomes
Published: July 2019

As mudanças propostas para o currículo trazem a pauta discussões sobre o que deve ou não ser ensinado na escola. Apesar disso o ambiente escolar continua tendo papel fundamental e preponderante no que se refere ao processo de formação de indivíduos em nossa sociedade. Na tentativa de buscar meios para auxiliar esse processo, no tocante a aprendizagem, o livro didático é um dos muitos recursos ofertados ao professor. Apesar de frequentes críticas sobre produção e distribuição, o livro não perde seu lugar por ser ainda o material mais utilizado pelos professores no ensino das disciplinas, sendo uma ferramenta influente na prática de ensino, adotado muitas vezes como “manual” de instrução na falta de um planejamento que supere o conteúdo como forma de repetição. O desafio da prática pedagógica é associar as demandas curriculares ao ensino de forma geral e, neste trabalho em específico, ao ensino de história. Diante desse contexto, este artigo tem por objetivo, é analisar comparativamente alguns conteúdos de História  após as diretrizes da BNCC. Apoiamos-nos nas discussões de Lopes e Macedo (2011) sobre currículo, Bittencourt (2009) sobre ensino de história e livro didático. Para atingir nosso objetivo, fizemos uma análise comparativa em um corpus, composto por dois capítulos sobre o tema escravidão, de dois livros didáticos de história, sendo o primeiro exemplar anterior a BNCC e o segundo do novo currículo. Os critérios para análise foram: 1) Recorrência do tema nos dois livros e 2) Parâmetros sugeridos pelos órgãos normativos sobre a estrutura, conteúdo e respeito às diversidades, culturais e regionais. Nosso trabalho justifica-se pela necessidade de identificar as mudanças curriculares na busca de oferecer reflexões e discussões concernentes à aplicabilidade da BNCC na ação docente e nos recursos pedagógicos. Observando a estruturação, conteúdos, atividades e ilustrações nos livros didáticos, anteriores e posteriores a perspectiva da nova base, espera-se como resultados identificar o impacto dessa possível efetivação curricular no ensino de história
Currículo e Educação Comparada: perspetivas e desafios
Authors: Morgado José Carlos
Published: July 2019

Neste artigo analisa-se a relação entre currículo e educação comparada. Partindo da ideia de que o currículo, como projeto formativo e como construção partilhada de saberes, se deve configurar de modo a garantir o desenvolvimento de indivíduos autónomos, moral e intelectualmente bem formados, capazes de continuar a aprender ao longo da sua vida e de assumirem um papel interventivo numa sociedade que muda de forma rápida e contínua, procura averiguar-se até que ponto a educação comparada contribui para que, no ensino superior, o processo de desenvolvimento do currículo se estruture em função de referentes mais amplos e atuais, oriundos tanto de distintos contextos nacionais como internacionais. A análise permitiu constatar que é necessário diluir certas tendências pragmáticas e mercantilistas que têm conformado o campo do currículo nos últimos anos e que interferem com os propósitos e os processos da educação comparada.
The relevance of the clinical management of hypothyroidism for HCA practice
Authors: Hayes Catherine , Keith Sarah , Graham Yitka
Published: July 2019

This article provides an insight for healthcare staff who may have limited knowledge of the implications of the pharmacological interventions for hypothyroidism to their everyday practice with patients. The historical perspectives explored in the article provide a contextual backdrop to modern prescribing practice and the specific expertise that this common condition necessitates if side effects are to be actively prevented. The incidence and prevalence rates of hypothyroidism ensure it remains one of the most commonly diagnosed endocrine disorders in medical practice.

The article also provides an insight into the most common characteristics of hypothyroidism, with the need for individualised management that encompasses due regard for the physiological impact of the condition in the lives of those people living with the condition.

Most importantly, the article provides an opportunity for healthcare staff to reflect with a degree of compassion on their own interaction with patients living with hypothyroidism, in order to maximise the potential of achieving a quality of life that is not characterised by ongoing symptoms of weight gain and tiredness.
Imaging-led symptomatic breast clinics: a case for direct access to radiology
Authors: Bansal GJ
Published: July 2019

Radiologists play a pivotal role in patient management in modern hospital medicine and more so with regard to breast imaging. The diagnosis of breast pathology hinges predominantly on mammography and ultrasound imaging. With reduced clinician confidence in clinical examination alone, virtually all patients with breast symptoms are being referred for imaging. The traditional ‘one-stop’ clinics are victims of their own success and demand outstrips availability. This article makes a case for imaging-led breast clinics to increase efficiency, reduce duplication of work and cost, and increase throughput of patients.
Research Roundup
Authors: Winter George
Published: July 2019

George Winter provides an overview of recently published articles that may be of interest to practice nurses. Should you wish to look at any of the papers in more detail, a full reference is provided.
Richness of Thalloid Liverworts in Bilaspur, Achanakmar-Amarkantak Biosphere Reserve and Lafa hills, Chhattisgarh (India)
Authors: Dixit Ashvini Kumar , Kerketta Mery Aradhna
Published: July 2019

A survey of bryophyte diversity in Bilaspur District (Chhattisgarh) and nearby areas has brought to light an unexpectedly rich bryoflora. Liverworts have a great diversity which includes both leafy and thalloid forms. Presence of 24 species of thalloid liverworts was recorded collectively from protected area Achanakmar-Amarkantak Biosphere reserve (AABR) as well as other regions of Bilaspur district and Lafa Hills, Korba. The main objective of this study is to evaluate the influence of elevation on the diversity of bryophytes in regional scale. For the study each location was mapped zone wise on 21 micro plots ranging between altitudes 230 m to 1011 m. Using presence or absence of species, bryophyte species richness was compared at each altitude. These zones exhibit high species richness at mid–high elevation (around 525-1000 m) with an average 4-6 species of distribution rate. It is observed 83% of liverwort population as terrestrial, 10% as epiphytic, 7% grows in aquatic habitats and below 5% recorded as ubiquitous at various altitude ranges. Species composition shows variability along the elevation and microhabitat distribution which shows homogeneity of liverwort population. This study reveals the current status of liverworts in Bilaspur region.
The effects of physical exercise on parahippocampal function
Authors: Loprinzi PD
Published: July 2019

Objective

The objective of this study was to examine the effects of physical exercise on parahippocampal function.

Methods

Studies were identified using electronic databases, including PubMed, PsychInfo, Sports Discus, and Google Scholar. In total, 28 articles met the inclusionary criteria. Among these, 20 were among humans and 8 in animal models. Among the 20 human studies that examined some aspects of the parahippocampal gyrus, 5 evaluated the entorhinal cortex and 1 evaluated the perirhinal cortex. Among the 20 human studies, 3 evaluated neural activity (or BOLD-signal changes), 14 evaluated brain volume (gray or white matter), 2 examined fractional anisotropy, 1 examined glucose metabolism, and 1 examined functional connectivity between the parahippocampal gyrus and a proximal brain tissue. Among the 8 animal studies, 4 evaluated the entorhinal cortex, with the other 4 examining the perirhinal cortex.

Results

The results demonstrated that, among both animal and human models, exercise had widespread effects on parahippocampal function. These effects, included, for example, increased neural excitability in the parahippocampal gyrus, increased gray/white matter, reduced volume of lesions, enhanced regional glucose metabolism, increased cerebral blood flow, augmented markers of synaptic plasticity, and increased functional connectivity with other proximal brain structures.

Conclusion

Exercise appears to have extensive effects on parahippocampal function.
Pengembangan Media Pembelajaran Wayang Profesi Untuk Mengenalkan Jenis Pekerjaan Pada Siswa SD
Authors: Kurniawan Dede Trie , Hayati Auliya Aenul , Maryanti Sri
Published: July 2019

This study aims to develop the lecture method of prospective elementary school teachers in utilizing puppet media as an implementation of local wisdom and storytelling skills in explaining the job profession to elementary school students. The use of puppets as learning media in the form of fairy tales contains subject matter that is rich in the applicative value of character education and moral values for students. Puppet shows can make learning more effective and efficient because of the elements of education such as students, educators, educational interactions, educational goals, subject matter, tools and methods and the educational environment to be fulfilled. One example of a theme in the 2013 curriculum that can use the puppet profession as an educational medium of moral value is the theme "Various Works" intended for fourth grade students of Elementary School. The method used to achieve the goal is through Development Research with the ADDIE model (Analysis, Design, Development, Implementation and Evaluation) which is directed at developing puppet media and fairy-tale texts that explain the occupational profession to elementary school students. This study seeks to develop lecture methods that can provide storytelling skills and make puppet media for prospective elementary school teacher students in one of the private colleges of the city of Cirebon in explaining my theme material and my dreams for elementary school students. Keywords: Traditional Puppet, Elementary School Learning Media, Thematic Basic Education
TRUST BUILDING PEDAGANG KAIN DAN PAKAIAN DI CIREBON
Authors: Dulkiah Moh.
Published: July 2019

This writting describes about interaction between one trader to other trader. In the interaction, both of them have unique relation. In the fact, the relation among them is based on personal trust. This study use descriptive methode in qualitative approach. The result of study is the key to the success of a cooperation is strongly influenced by mutual trust that is raised by all parties involved. The sustainability of a cooperation is strongly influenced by the size of the degree of confidence (radius of trust) that is established among the parties involved. Cooperation will be easy to do and can last long if it builds a high value/norm of trust. Conversely cooperation will be easily destroyed even not formed at all if in it has a value/norm of trust is low. Thus the high level of cooperation is very inhern with how much value/norm of trust formed between the parties involved in cooperation
KEBIJAKAN BANDUNG TRANSIT AREA (BTA) UNTUK PENINGKATAN KUNJUNGAN WISATA
Authors: Ishak Deding , Maolani Dedeng Yusuf , Chotim Endah Ratnawaty , Sari Avid Leonardo
Published: July 2019

Masalah utama dalam penelitian ini adalah peran dan fungsi komponen pariwisata dan pemerintah masih rendah. Hal ini disebabkan oleh kegiatan bidang pariwisata belum sepenuhnya dikelola dengan baik.Tujuan penelitian ini adalah: (1) menyusun strategi optimalisasi komponen destinasi wisata Bandung Transit Area (BTA). (2) menyusun strategi optimalisasi peranan pemerintah dalam pembangunan Bandung Transit Area (BTA). Metode penelitian yang digunakan adalah analisis SWOT yang merupakan singkatan dari Strength (S), Weakness (W), Opportunities (O), dan Threats (T) artinya kekuatan, kelemahan, peluang dan ancaman/kendala, dimana secara sistematis dapat membantu dalam mengidentifikasi faktor-faktor: luar (O dan T) dan faktor di dalam organisasi (S dan W). Tahap awal penelitian adalah menaksir kekuatan, kelemahan, kesempatan, dan ancaman yang dimiliki organisasi. Hasil analisis dapat dilakukan perubahan pada misi, tujuan, kebijakan, atau strategi yang sedang berjalan. Hasil penelitian bahwa Peran Pariwisata di wilayah Bandung telah menjadi suatu industri dan memiliki peran yang besar bagi pembangunan Wilayah Bandung. Wilayah Bandung merupakan kota tujuan wisata utama di wilayah Jawa Barat. Selain itu berbagai faktor seperti posisi Bandung sebagai pusat pemerintahan, pusat kegiatan jasa dan kegiatan perekomian, serta kondisi geografis wilayah Bandung mendukung untuk menjadi salah satu tujuan wisata utama di Jawa Barat.
MANAJEMEN PESANTREN DALAM PEMBANGUNAN DESA
Authors: Mustari Mohammad , Maolani Dedeng Yusuf
Published: July 2019

Tujuan kajian ini adalah untuk membuat analisis sistematis yang mendalam terhadap peran dan kontribusi pesantren dalam pembangunan wilayah perdesaan, terutama di Kab. Tasikmalaya yang jumlahnya telah mencapai 761 pesantren. Kajian ini menggunakan metode kajian kasus berganda. Kasus-kasusnya terdiri dari enam pesantren (tiga pesantren besar dan tiga pesantren kecil), semuanya berlokasi di Kab. Tasikmalaya. Pemilihan pesantren-pesantren itu disebabkan karena mewakili dari tiga kategori: tradisional, modern, dan kombinasi. Wawancara, pengamatan, dan analisis dokumen digunakan untuk mengumpulkan data. Wawancara tatap muka memakai daftar pertanyaan yang dikembangkan untuk kajian ini. Temuan kajian menunjukkan bahwa semua pesantren merancang sendiri dan melaksanakan rencana pembangunan, baik untuk di dalam pesantren itu sendiri maupun untuk pembangunan desa, yang menjadi lingkungan sosialnya, karena kebanyakan pesantren itu berada di perdesaan.