bluuebunny/crossref_metadata_2025 huggingface dataset:
Current Standard and Future Perspectives in Non-Surgical Therapy for Hepatocellular Carcinoma
Authors: Eggert Tobias , Greten Tim F.
Published: June 2017

Background: Hepatocellular carcinoma (HCC) is an aggressive liver tumor with a poor 5-year survival rate. Many HCCs are not amenable to surgical resection, because of tumor size, location, or because of the patient's poor liver function, a common obstacle to HCC therapy, because HCCs almost always develop in chronically inflamed livers. Summary: In recent years, many efforts have been made to improve patient survival by conducting clinical trials investigating local and systemic treatment options for patients with unresectable tumors. These treatment options include radiofrequency ablation (RFA), transarterial chemoembolization (TACE), selective internal radiotherapy with yttrium-90 (SIRT), stereotactic body radiation therapy (SBRT), proton beam therapy, molecular targeted therapy, and checkpoint inhibition. In this “to-the-point” article, we review the current standard and summarize the most recent findings in unresectable HCC treatment. Key Points: (1) RFA is currently the preferred treatment for patients with tumor burden restricted to the liver and not eligible for surgical resection; (2) TACE is utilized in patients who are not eligible for RFA because of tumor location and/or number of tumor lesions; (3) SIRT might improve treatment responses achieved by TACE and is feasible in patients with portal vein thrombosis; (4) new radiation therapy treatment modalities such as SBRT and proton beam therapy show promising results for local tumor control; and (5) sorafenib remains the first-line systemic treatment option after several large clinical trials have failed to show superiority of other molecular targeted therapies in HCC patients.
Relationship between Changes in Fatty Acid Composition of the Erythrocyte Membranes and Fatty Acid Intake during Pregnancy in Pregnant Japanese Women
Authors: Kitamura Yohei , Kogomori Chieko , Hamano Hirokazu , Maekawa Iwao , Shimizu Takashi , Shiga Seigo
Published: June 2017

Objective: Docosahexaenoic acid (DHA) is an important nutrient required by pregnant women and fetuses. Several studies suggest that fatty acid composition changes during pregnancy. However, the association of longitudinal changes in erythrocyte fatty acid composition and dietary fatty acid intake during pregnancy is not well understood. We assessed the relationship between fatty acid composition of the erythrocyte membranes and fatty acid intake at each trimester in pregnant Japanese women. Methods: We conducted a prospective hospital-based cohort study. We investigated fatty acid composition of the erythrocyte membranes and intake of fatty acids during the three trimesters in 178 healthy, pregnant Japanese women. Results: The eicosapentaenoic acid and arachidonic acid percentage of the erythrocyte membranes significantly decreased. The percentages of linoleic acid and α-linolenic acid significantly increased during pregnancy. The DHA percentage in the erythrocyte membranes decreased from the second to the third trimester. The DHA percentage in the erythrocyte membranes positively correlated with DHA intake in the third trimester. Conclusion: In pregnant Japanese women, the fatty acid composition of the erythrocyte membranes markedly changed throughout pregnancy. The DHA intake in the third trimester may be insufficient to maintain DHA percentage in the maternal erythrocyte membranes.
Gemcitabine and Vinorelbine Combination Chemotherapy in Taxane-Pretreated Patients with Metastatic Breast Cancer: A Phase II Study of the Kinki Multidisciplinary Breast Oncology Group (KMBOG) 1015
Authors: Yamamura Jun , Masuda Norikazu , Yamamoto Daigo , Tsuyuki Shigeru , Yamaguchi Masahide , Tanaka Satoru , Tsurutani Junji , Tokunaga Shinya , Yoshidome Katsuhide , Mizutani Makiko , Aono Toyokazu , Ooe Asako , Tanino Hirokazu , Matsunami Nobuki , Yasojima Hiroyuki , Nakayama Takahiro , Nishida Yukihiro
Published: June 2017

Background: This phase II study was conducted to evaluate the efficacy and safety of the chemotherapy combination of gemcitabine and vinorelbine in taxane-pretreated Japanese metastatic breast cancer patients. Methods: In this multicenter, phase II, single-arm study, patients with recurrent or metastatic HER2-negative breast cancer were administered gemcitabine (1,200 mg/m2) and vinorelbine (25 mg/m2) intravenously on days 1 and 8 every 3 weeks. The primary endpoint was the objective response rate, and other endpoints included progression-free survival, overall survival, and safety. Results: A total of 42 patients were enrolled in this study. The objective response rate and clinical benefit rate were 24 and 43%, respectively. The median progression-free survival was 4.0 months. The median overall survival was 11.1 months. Grade 3/4 neutropenia was the most common hematologic toxicity, occurring in 22 patients (54%). Nonhematologic toxicity was moderate and transient, with fatigue (48%) being the most common condition and no severe adverse event reported. Conclusion: The combination of gemcitabine and vinorelbine is an effective and tolerable regimen for HER2-negative, taxane-pretreated, metastatic breast cancer patients in Japan.
Low-Level Chromosomal Mosaicism in Neurodevelopmental Disorders
Authors: Oneda Beatrice , Asadollahi Reza , Azzarello-Burri Silvia , Niedrist Dunja , Baldinger Rosa , Masood Rahim , Schinzel Albert , Latal Bea , Jenni Oskar G. , Rauch Anita
Published: June 2017

Chromosomal mosaicism, which represents a diagnostic challenge for detection and interpretation, has been described in several genetic conditions. It can contribute to a large phenotypic variation in diseases. At analysis of a well-characterized cohort of 714 patients with neurodevelopmental disorders (NDDs) of unknown etiology using a high-resolution chromosomal microarray platform, we found 2 cases (0.28%) of low-level mosaicism and defined a previously detected extra chromosome in a third patient. Two of the cases were mosaics for segmental imbalances (a partial trisomy 3q26.1q27.3 and a partial monosomy 18q21.2qter with 14.6 and 20% mosaic ratios in lymphocytes, respectively), and 1 was a mosaic for an entire chromosome (trisomy 14, mosaic ratio 20%). Our diagnostic yield is in line with the ratios previously published in patients with intellectual disability. Notably, the partial trisomy 3q26.1q27.3 case is an example of a rare and unusual class of a rearranged neocentric ring chromosome, which can neither be categorized in class I, nor in class II of such rearrangements. Our cases further elucidate the phenotypes related to the aberrations of the specific chromosome segments observed and underline the important role of low-level mosaics in the pathogenesis of NDDs of unknown etiology even in the absence of clinical signs of mosaicism.
The New Digital Divide For Digital Biomarkers
Authors: Torous John , Rodriguez Jorge , Powell Adam
Published: June 2017

As smartphone and sensors continue to become more ubiquitous across the world, digital biomarkers have emerged as a scalable and practical tool to explore disease states and advance health. However, as the digital divide of access and ownership begins to fade, a new digital divide is emerging. Who are the types of people who own smartphones or smart watches, who are the types of people who download health apps or partake in digital biomarker studies, and who are the types of people who are actually active with digital biomarker apps and sensors – the people providing the high-quality and longitudinal data that this field is being founded upon? Understanding the people behind digital biomarkers, the very people this emerging field aims to help, may actually be the real challenge as well as opportunity for digital biomarkers.
Incomplete Large Vessel Occlusions in Mechanical Thrombectomy: An Independent Predictor of Favorable Outcome in Ischemic Stroke
Authors: Maus Volker , You Seunghwa , Kalkan Alev , Borggrefe Jan , Kabbasch Christoph , Barnikol Utako Birgit , Stetefeld Henning , Dohmen Christian , Liebig Thomas , Fink Gereon Rudolf , Mpotsaris Anastasios
Published: June 2017

Background and Purpose: Cerebral large vessel occlusion (LVO) in acute ischemic stroke (AIS) may be complete (CLVO) or incomplete (ILVO). The influence of ILVO on clinical outcome after mechanical thrombectomy (MT) remains unclear. We investigated primarily the clinical outcome in patients with AIS due to ILVO or CLVO. Methods: Five hundred three consecutive AIS patients with LVO treated with stent-retriever or direct aspiration-based MT between 2010 and 2016 were analyzed. The primary endpoint was favorable clinical outcome (modified Rankin Scale ≤2) at 90 days; secondary endpoints were periprocedural parameters. Results: Forty-nine patients (11.3%) with a median National Institutes of Health Stroke Scale (NIHSS) of 11 presented with ILVO and the remainder presented with CLVO and median NIHSS of 15 (p < 0.001). The median groin puncture-to-reperfusion time was 30 vs. 67 min, respectively (p < 0.001). Successful reperfusion was reached in 47 out of 49 ILVO (95.9%) vs. 298 out of 381 CLVO (78.2%; p < 0.005) with less retrieval maneuvers (1.7 ± 2.2 vs. 3.0 ± 2.5; p < 0.001). The favorable outcome at 90 days was 81% in patients with ILVO vs. 29.1% in CLVO (p < 0.001); respective all-cause mortality rates were 6.4 vs. 28.5% (p < 0.001). Periprocedural complications (6.9%) occurred exclusively in CLVO patients (p < 0.05). ILVO was associated with favorable clinical outcome independent of age and NIHSS in multivariate logistic regression both in the anterior (OR 3.6; 95% CI 1.8-6.9; p < 0.001) and posterior circulation (OR 3.5; 95% CI 1.8-6.9; p < 0.001). Conclusions: AIS due to ILVO is frequent and is associated with a nearly threefold higher chance of favorable clinical outcome at 90 days, independent of age and initial NIHSS compared to CLVO.
Access to Justice for National Minorities – A Recurrent Theme in the Work of the osce High Commissioner on National Minorities
Authors: Hadirca Laurentiu
Published: June 2017

This article provides an overview of the work of the osce hcnm on issues of access to justice for national minorities, based on a review of relevant thematic recommendations, country-specific advice, official statements, as well as other activities, projects and engagements of the hcnm. The article analyses how the hcnm’s specific mandate – as a political institution tasked to prevent inter-ethnic conflict, operating primarily through “quiet diplomacy” – has shaped its approach to human and minority rights, and to access to justice issues in particular. The overview shows that throughout the years, access to justice has become a recurrent, if at times tangential, theme for the institution. Overall, the article seeks to distil the general hcnm approach to access to justice issues as it was conveyed through a variety of thematic recommendations and guidelines, specific advice and other relevant engagements, undertaken in the course of the two-and-a-half decades of the institution’s existence.
New distributional records and life stage description of Caenis species (Ephemeroptera: Caenidae) from Brazil
Authors: LIMA LUCAS R. C. , BOLDRINI RAFAEL
Published: June 2017

The genus Caenis Stephens, 1835 is well represented in South America with 24 recorded species (14 in Brazil). Based on additional material from Brazil, we describe for the first time the nymphal and egg stages of C. reissi, and re-describe the eggs of C. cuniana. New distributional records for these species and Caenis elidioi are given, and C. teipunensis (previously described from Venezuela) is reported for the first time from Brazil.
A new genus for the Blue-and-yellow Tanager (Aves: Passeriformes): a suggested adjustment to the classification of the Thraupidae
Authors: PIACENTINI VÍTOR DE Q.
Published: June 2017

Recent DNA-based studies have found that the genus Thraupis, as traditionally defined, is polyphyletic, with the Blue-and-yellow Tanager (historically treated as Thraupis bonariensis) being sister to the Fawn-breasted Tanager (Pipraeidea melanonota). As a result, most subsequent classifications lumped both species under a single genus, Pipraeidea. Here I show that both species differ markedly in plumage, morphology, voice, and behavior, each of them being more similar to a distantly related species than to each other. As such, I argue that the treatment of the Blue-and-yellow Tanager in Pipraeidea creates an undiagnosable genus contrasting greatly with the generic limits commonly applied to the tanagers. To avoid this situation, I propose the recognition of a new genus, Remsenornis gen. nov., for the Blue-and-yellow Tanager.
A new species of Pseudocalotes (Squamata: Agamidae) from the Bukit Barisan Range of Sumatra with an Estimation of its phylogeny
Authors: HARVEY MICHAEL B. , SHANEY KYLE , HAMIDY AMIR , KURNIAWAN NIA , SMITH ERIC N.
Published: June 2017

We describe a new species of Pseudocalotes from montane forests of the central, western coast of Sumatra. The combination of 3 or 4 interoculabials, slightly enlarged and heavily keeled scales on the lower flanks, a white scapular spot, a relatively long fifth toe, bicarinate lamellae at the base of Toe III, absence of a postrictal modified scale, and three rows of paravertebrals directed dorsally and posteriorly distinguishes the new species from its congeners on Sumatra and Java. Among the new characters defined in this study, counts of subdigital lamellae within the “span of Toe V” proved particularly useful for diagnosing species of Pseudocalotes. Phylogenetic analysis of DNA sequences identified a monophyletic group containing the Sumatran and Javan Pseudocalotes. Based on the phylogeny, we define a P. cybelidermus Group containing P. cybelidermus and P. guttalineatus and a P. tympanistriga Group containing P. tympanistriga, P. rhammanotus, and the new species. Combinations of five morphological characters define each of these two clades. As currently defined, Pseudocalotes is polyphyletic; Javan and Sumatran species are more closely related to other draconines such as Dendragama boulengeri than they are to some mainland species.
Homicide among the Elderly: The Metro Dade County Experience, 1979–83
Authors: Copeland Arthur R.
Published: June 2017

The elderly homicide victim was studied. A total of 129 homicide cases in which the decedent was aged 65 years or more were collected from the records of the Office of the Medical Examiner between the years 1979–83. The cases were then analysed as to age, race, sex, cause of death, results of toxicology, and scene circumstances. The protatypical victim was found to be a 65– to 85-year-old white male who died from either a gunshot wound or blunt trauma resulting from a robbery or burglarly at home. Suggestions are given on how to avoid such tragedies.
Death Associated with the Abuse of Typewriter Correction Fluid
Authors: Ranson D. L. , Berry P. J.
Published: June 2017

A case is reported of a 13-year-old boy who died suddenly during physical exercise. Post-mortem examination showed no macroscopic or histological abnormalities and it was only later that he was discovered to be a regular solvent abuser of typewriter correcting fluid containing the solvent 111 Trichloroethane. Typewriter correcting fluid is a relatively unusual substance for solvent abuse, and this case demonstrates the wide range of products which are inhaled by children. The implications of the abuse of 111 Trichloroethane are discussed, with particular reference to the possible mode of death in such cases.
Aerodynamic and static aeroelastic computations of a slender rocket with all-movable canard surface
Authors: Dongyang Chen , Abbas Laith K , Xiaoting Rui , Guoping Wang
Published: June 2017

The present paper is undertaken to better understand the impact of the all-movable canard surface on the aerodynamic and static aeroelastic of slender rocket. Numerical simulations are performed to numerically calculate the guided rocket aerodynamic coefficients using commercial steady-state Computational Fluid Dynamics software ANSYS®-CFX. The variations of lift and drag coefficients with Mach number are demonstrated in the linear range of angles of attack. Comparison is made between the aerodynamic results and experimental data, which verified the accuracy of the fluid domain numeric method. Rocket static aeroelastic study is simulated through the inertia relief approach and fluid–structure interaction two-way loosely coupled methods based on multi-physics coupling platform ANSYS Workbench. Comparisons are also made between the results and AGARD 445.6-Wing standard model. Moreover, the composite material is carried out to improve the canards strength. Numerically, it indicates that deflected angle of all-movable canard surface has remarkable effect on the aerodynamics of the rockets. Aerodynamic loads are mainly contributed to the static deformation of the flexible rocket, while thrust effect is tiny and may ignore. The static deformations push the center of pressure forward and increase the trim angle. By product, rocket control effectiveness is decreased about 38%. Canards with the original material experiences stresses beyond the allowable due to static deformation at high supersonic speed. Hence, composite material is adopted for strengthening the canards.
Worldwide Regulatory Guidance Values Applied to Direct Contact Surface Soil Pesticide Contamination: Part I—Carcinogenic Pesticides
Authors: Jennings Aaron A , Li Zijian
Published: June 2017

Regulatory agencies worldwide have developed regulatory guidance values (RGVs) for nearly 800 pesticides. Analysis of the residential surface soil guidance values applied to the most frequently regulated current-use agriculture, home, and garden pesticides is presented. Part I concentrates on values applied to atrazine, simazine, and trifluralin. These are unique among commonly used pesticides because they are generally considered to be human carcinogens. Their use has been banned in much of the world, but they are commonly used in the United States. Regulatory guidance values applied to these 3 pesticides vary by 8.6, 5.5, and 5.1 orders of magnitude. Risk model coefficient–bounded set uncertainty analysis is applied to help analyze this variability. Cancer risk model uncertainty bounds appear to contain 36.3%, 43.0%, and 49.5% of the RGVs. Most of the remaining values appear to exceed a lifetime cancer incidence risk of 1 × 10−6 and may not be adequately protective of human health.
Barriers to Integrating Quantitative and Qualitative Research
Authors: Bryman Alan
Published: June 2017

This article is concerned with the possibility that the development of mixed methods research is being hindered by the tendency that has been observed by some researchers for quantitative and qualitative findings either not to be integrated or to be integrated to only a limited extent. It examines findings from 20 interviews with U.K. social researchers, all of whom are practitioners of mixed methods research. From these interviews, a wide variety of possible barriers to integrating mixed methods findings are presented. The article goes on to suggest that more attention needs to be given to the writing of mixed methods articles.
New and unusual Pd-Tl-bearing mineralization in the Anomal'nyi deposit, Kondyor concentrically zoned complex, northern Khabarovskiy kray, Russia
Authors: Barkov Andrei Y. , Shvedov Gennadiy I. , Polonyankin Alexander A. , Martin Robert F.
Published: June 2017

New Pd-Tl-(Bi,As)-rich compounds are described from the Anomal'nyi Cu-PGE deposit, Kondyor alkaline ultramafic complex, northeastern Russia. They occur in vein-type settings associated with bodies of 'kosvite' (magnetite-rich clinopyroxenite) in the dunite-(peridotite) core, in pegmatiticand micaceous rocks. The ore zones are substantially enriched in phlogopite; they consist of diopside, disseminated titaniferous magnetite and fluorapatite (Sr-bearing). The observed assemblages of ore minerals include sulfides of the chalcopyrite-bornite-(secondary chalcocite) associationand various species of platinum-group minerals (PGM) [isomertieite or arsenopalladinite rich in Sb, mertieite-II, mertieite-I, sobolevskite, kotulskite, merenskyite, zvyagintsevite, palarstanide, paolovite, sperrylite, maslovite or moncheite, hollingworthite and unnamed species of PGM] anda Ag-Au alloy. The oxides [Pd4(Bi,Te,Tl)O6 and Pd4(Tl,Bi,Te)O6] probably formed in situ by oxidation reactions at the expense of the associated PGM intergrowths. These involve palladium bismuthide-thallide phases, Pd5(Tl,As,Bi)and Pd5(As,Tl,Bi), which are documented here for the first time. A fairly evolved environment, enriched in Cu, Pd, Te, Bi, Pb and volatile components, is indicated for the vein-type deposit at Anomal'nyi.
Melonite from Kingash and Kuskanak, Eastern Sayans, Russia, and the extent of Bi-for-Te substitution in melonite and synthetic Ni(Te,Bi)2–x
Authors: Barkov Andrei Y. , Shvedov Gennadiy I. , Flemming Roberta L. , Vymazalová Anna , Martin Robert F.
Published: June 2017

We describe occurrences of palladoan melonite in intimate intergrowths with cobaltite-gersdorffite from the Neoproterozoic dunite-wehrlite-gabbro complexes of Kingash and Kuskanak, Eastern Sayans, Russia. The observed compositional trends of melonite are consistent with the overallvariations examined on the basis of numerous literature sources. The levels of Bi in NiTe2are normally limited to ≤0.25 Bi atoms per formula unit (apfu), under natural conditions. Greater levels (≤0.5 Bi apfu) are associated with the (Pd + Pt) enrichment in the palladoanvarieties. The telluride–sulfarsenide intergrowths probably formed at Kingash and Kuskanak late in the crystallization history of the ore zones, from microdroplets of residual melt rich in semimetals (Te, Bi, As) and noble metals (Pd and Ag), below the solidus of the enclosing gabbroicrocks and within a narrow range of temperatures (500–550°C). On the basis of our observations made on specimens of melonite and synthetic Ni(Te,Bi)2–x(x = 0.6), we infer that the limit of incorporation of Bi into a melonitetype phase is ≤0.5 Bi apfu.
The crystal chemistry of oxo-mangani-leakeite and mangano-mangani-ungarettiite from the Hoskins mine and their impossible solid-solution: An XRD and FTIR study
Authors: Oberti Roberta , Ventura Giancarlo Della , Boiocchi Massimo , Zanetti Alberto , Hawthorne Frank C.
Published: June 2017

New chemical (EMP, SIMS) and structural data are reported for a suite of crystals of oxo-mangani-leakeite and mangano-mangani-ungarettiite from their common type locality, the Hoskins mine (New South Wales, Australia). Notwithstanding the low OH content, FTIR analysis of selected sampleshas provided considerable information on short-range order in these Mn3+-rich amphiboles, and shows that Li is associated with occupied A sites and is linked to the oxo-component at the O(3) site. Comparative analysis of all available data allows us to: (1) further improveour understanding of the crystal-chemistry of these very peculiar compositions of the oxo-amphibole group; and (2) calculate reliable site-populations. The proposed limited compositional variability has been confirmed. The two amphiboles have completely different arrangements of CR3+cations. In oxo-mangani-leakeites, those CR3+ cations related to the oxocomponent occur at the M (1) site, whereas those CR3+ cations related to the leakeite charge-arrangement occur at the M (2) site. In mangano-mangani-ungarettiite,all CR3+ cations order at the M (1) and M (3) sites, and local bond-valence requirements are satisfied by the presence of Mn3+, which assumes a strongly distorted coordination due to its degenerate eg electronic state. Therefore,the inverse patterns observed for both cation-ordering and deformation of the octahedra are incompatible with solid-solution between these two species that coexist at the Hoskins mine.
Carboplatin and Etoposide With or Without Palifosfamide in Untreated Extensive-Stage Small-Cell Lung Cancer: A Multicenter, Adaptive, Randomized Phase III Study (MATISSE)
Authors: Jalal Shadia I. , Lavin Philip , Lo Gregory , Lebel Francois , Einhorn Lawrence
Published: June 2017

Purpose

To evaluate the efficacy of the addition of palifosfamide to carboplatin and etoposide in extensive stage (ES) small-cell lung cancer (SCLC).

Patients and Methods

MATISSE was a randomized, open-label, adaptive phase III study. Previously untreated patients with ES SCLC were randomly assigned in a 1:1 fashion to receive carboplatin at area under the serum concentration-time curve 5 on day 1 plus etoposide 100 mg/m2 per day on days 1 to 3 every 21 days (CE) or carboplatin at area under the serum concentration-time curve 4 on day 1 plus etoposide 100 mg/m2 per day plus palifosfamide 130 mg/m2 per day on days 1 to 3 every 21 days (PaCE). The primary end point was overall survival.

Results

In all, 188 patients were enrolled; 94 patients received CE and 94 patients received PaCE. The median age on both arms was 61 years. Six cycles of chemotherapy were completed on both arms of the study by approximately 50% of the patients. Serious adverse events were documented and did not differ significantly between patients receiving PaCE and those receiving CE. Median overall survival was similar between both arms with 10.03 months on PaCE and 10.37 months on CE ( P = .096).

Conclusion

The addition of palifosfamide to CE failed to improve survival in ES SCLC.
Malignant Pheochromocytoma and Paraganglioma: 272 Patients Over 55 Years
Authors: Hamidi Oksana , Young William F , Iñiguez-Ariza Nicole M , Kittah Nana Esi , Gruber Lucinda , Bancos Cristian , Tamhane Shrikant , Bancos Irina
Published: June 2017

Context

Malignant pheochromocytoma (PHEO) and paraganglioma (PGL) are rare and knowledge of the natural history is limited.

Objective

We aimed to describe baseline characteristics and outcomes of patients with malignant PHEO and PGL (PPGL) and to identify predictors of shorter survival.

Design

Retrospective review of patients with malignant PPGL evaluated from 1960 to 2016.

Setting

Referral center.

Patients

The group comprised 272 patients.

Main Outcome Measures

Baseline description, survival outcomes, and predictors of shorter survival were evaluated in patients with rapidly progressive (n = 29) and indolent disease (n = 188).

Results

Malignant PPGL was diagnosed at a median age of 39 years (range, 7 to 83 years), with synchronous metastases in 96 (35%) patients. In 176 (65%) patients, metastases developed at a median of 5.5 years (range, 0.3 to 53.4 years) from the initial diagnosis. Median follow-up was 8.2 years (range, 0.01 to 54.1 years). Median overall and disease-specific survivals were 24.6 and 33.7 years, respectively. Shorter survival correlated with male sex (P = 0.014), older age at the time of primary tumor (P = 0.0011), synchronous metastases (P < 0.0001), larger primary tumor size (P = 0.0039), elevated dopamine (P = 0.0195), and not undergoing primary tumor resection (P < 0.0001). There was no difference in the type of primary tumor or presence of SDHB mutation.

Conclusions

The clinical course of patients with malignant PPGL is remarkably variable. Rapid disease progression is associated with male sex, older age at diagnosis, synchronous metastases, larger tumor size, elevated dopamine, and not undergoing resection of primary tumor. An individualized approach to patients with metastatic PPGL is warranted.
Insights for conducting real-time focus groups online using a web conferencing service
Authors: Kite James , Phongsavan Philayrath
Published: June 2017

Background: Online focus groups have been increasing in use over the last 2 decades, including in biomedical and health-related research. However, most of this research has made use of text-based services such as email, discussion boards, and chat rooms that do not replicate the experience of face-to-face focus groups. Web conferencing services have the potential to more closely match the face-to-face focus group experience, including important visual and aural cues. This paper provides critical reflections on using a web conferencing service to conduct online focus groups.

Methods: We conducted both online and face-to-face focus groups as part of the same study. The online groups were conducted in real-time using the web conferencing service, Blackboard CollaborateTM. We used reflective practice to assess the similarities and differences in the conduct and content of the groups across the two platforms.

Results: We found that further research using such services is warranted, particularly when working with hard-to-reach or geographically dispersed populations. The level of discussion and the quality of the data obtained was similar to that found in face-to-face groups. However, some issues remain, particularly in relation to managing technical issues experienced by participants and ensuring adequate recording quality to facilitate transcription and analysis.

Conclusions: Our experience with using web conferencing for online focus groups suggests that they have the potential to offer a realistic and comparable alternative to face-to-face focus groups, especially for geographically dispersed populations such as rural and remote health practitioners. Further testing of these services is warranted but researchers should carefully consider the service they use to minimise the impact of technical difficulties.
Tamanho de estacas e uso de ácido indol-butírico ou preparado homeopático de Arnica montana na propagação de falsa-érica
Authors: Cassol Darcieli Aparecida , Dotto Marcelo , Pirola Kelli , Júnior Américo Wagner
Published: June 2017

The market for flowers and ornamental plants is growing. Since the false-érica (Cuphea gracilis) is a plant with many uses in the landscape, adapting to partial shade or full sun can be used for ground covers or chromatic combinations with other plants. Usually, the false-erica is propagated by seeds or by cuttings. The objective of this study was to evaluate the size of stakes and the concentration of IBA (indole butyric acid) and prepared homeopathic base of Arnica montana in rooting false-erica stakes. The collection of cuttings was carried out in arrays plants grown in gardens in standard sizes 6 and 12 cm in length, and were treated with IBA at concentrations of 0; 1.000 and 2.000 mg L-1 in addition to the homeopathic preparation A. montana 12 CH. The experiment was conducted in a completely randomized design in a 2x4 factorial [length x stake stimulant treatment], with 4 replications of 10 cuttings per plot. After 45 days, they were evaluated percentage of rooted and dead cuttings, root length (cm), number of shoots and number of leaves. The concentrations of AIB, and the application of homeopathy stimulated the adventitious rooting processes of this kind.
INDICE
Authors: - -
Published: June 2017

INDICE
UTILIZACIÓN DE OXITETRACICLINA E HIDROCORTISONA PARA EVITAR ADHERENCIAS EN DISPOSITIVOS INTRAVAGINALES EN OVINOS
Authors: SOSA J. L. , FERNANDEZ G. , BOGGERO C. , TOFFOLI G. D. , LEVA P. E. , GARCIA M. S.
Published: June 2017

Los dispositivos intravaginales son utilizados para la inducción y sincronización de celos. Los mismos pueden producir adherencia en las paredes de la vagina. El objetivo del presente trabajo fue probar la efi ciencia de la aplicación de antibióticos y corticoide conjuntamente con los dispositivos para evitar adherencias. La experiencia se realizó con 45 ovejas distribuidas en tres grupos: GC dispositivo sin tratamiento, T1 dispositivo más tetraciclina y T2 dispositivo más tetraciclina y corticoide. Siguiendo el protocolo se procedió al retiro de los mismos a los 12 días. Se realizó un test χ2 para evaluar la efectividad del tratamiento. Las ovejas del T2 no presentaron adherencias. En cambio, se observaron distintos grados de adherencias: en el T1 (53 %) y en el GC (46 %). Se puede inferir que la utilización de Tetracicilina más hidrocortisona es efi ciente para evitar la vaginitis y por ende la adherencia de los dispositivos y pérdida por disminución de preñeces posteriores al retiro de los dispositivos.
Analysis of Asset Growth Anomaly on Cross-Section Stock Returns: Evidence from Indonesia Stock Exchange
Authors: Iqbal Muhammad , Wibowo Buddi
Published: June 2017

Assorted types of market anomalies occur when stock prices deviate from the prediction of classical asset pricing theories. This study aims to examine asset growth anomaly where stocks with high asset growth will be followed by low returns in the subsequent periods. This study, using Indonesia Stock Exchanges data, finds that an equally-weighted low-growth portfolio outperforms high-growth portfolio by average 0.75% per month (9% per annum), confirming existence of asset growth anomaly. The analysis is extended at individual stock-level using fixed-effect panel regression in which asset growth effect remains significant even with controlling other variables of stock return determinants. This study also explores further whether asset growth can be included as risk factor. Employing two-stage cross-section regression in Fama and Macbeth (1973), the result aligns with some prior studies that asset growth is not a new risk factor; instead the anomaly is driven by mispricing due to investors’ overreaction and psychological bias. This result imply that asset growth anomaly is general phenomenon that can be found at mostly all stock market but in Indonesia market asset growth anomaly rise from investors’ overreaction, instead of  playing as a factor of risk.
The Effect of Consumer Expectation Index, Economic Condition Index and Crude Oil Price on Indonesian Government Bond Yield
Authors: Tjandrasa Benny Budiawan
Published: June 2017

Governments sell bonds to finance their budget. The investors willing to buy government bonds because of the yield they will get, but on the other hand if government bond yields is  too high it would burden the state in paying the interest due. Various studies have been done to find the variables that affect government bond yield significantly, such as exchange rate, inflation rate, interest rate, and oil price. This study found two more variables namely consumer expectations index and the economic conditions index to complement the variables that have been discovered. Those two variables are used as a proxy of economic stability of a country, the increase of those variables represent the increase of economic stability and will reduce the level of risk and lowering the yield that investors demand. This research use descriptive method and explanatory study with secondary data using multivariate regression equation model. The results shown consumer expectation index and economic condition index have significant effect on Indonesian Government Bond yield. To keep consumer expectation index and economic condition index increase government should give a positive signal and a sense of security to investor.
Internalization Mediation towards the Relationship between Entrepreneurial Action and Individual Performance for the Next Generation of Family Companies in Surabaya
Authors: Mustikarini Carolina Novi
Published: June 2017

This study  examined the effect of entrepreneurial action for the performance of the next generation using the sample of students who joined the Family Business Community. In this study, there is a high contribution given by the role of entrepreneurship education in preparing the next generation in the family business. In addition, entrepreneurship education is considered possible through the process of internalization of the leaning process that is going on. For example, it is noted that entrepreneurial action can have a significant effect on the performance of the organization. In the context of the family business and entrepreneurial education at the University of Ciputra, both variables (entrepreneurial action and individual performance) are necessary to be tested and therefore, the researcher finds it possible to cary out a research that is supposed to have a contribution to the family business. This study uses a hierarchical regression analysis, to test the stages of the mediation process. The results showed that most of relationships mediate internalization Entrepreneurial Action and Individual Performance.
Free to Serve? Emergency Food and Volunteer Labor in the Urban U.S.
Authors: Dickinson Maggie
Published: June 2017

Since the 1980s, cutbacks to welfare programs, widespread economic insecurity, and increased federal funding for nonprofit agencies have led to a massive expansion of emergency food providers (EFPs) such as soup kitchens and food pantries across the United States. These anti-hunger organizations are often staffed exclusively or predominantly by volunteers who are empowered to care for their communities. But, like all caring labor, volunteer work is shaped by race, class, and gender inequalities. Hunger and poverty motivate poor women to become volunteers, and contradictions around how this labor should be remunerated, recognized, and regulated create conflicts within EFPs. By mobilizing large numbers of poor, hungry people as volunteers to distribute surplus food, emergency food providers transform both wasted food and people who are typically considered “burdens” on the state into an important new form of free labor for a struggling economy in ways that deepen existing social inequalities.
Experimental reprogramming of murine embryonic fibroblasts towards induced pluripotent stem cells using a single polycistronic vector
Authors: Huynh Oanh Thuy , Truong Mai Thi-Hoang , Pham Phuc Van
Published: June 2017

Introduction: Embryonic stem cells are pluripotent, thus capable of differentiating into all types of cells derived from the three germ layers. However, the application of embryonic stem cells (ESCs) for preclinical and clinical studies is difficult due to ethical concerns. Induced pluripotent stem cells (iPSCs) are derived from differentiation and have many ESC characteristics. The study herein examines the production of iPSCs from reprogramming of mouse embryonic fibroblasts (MEFs) via transduction with defined factors.
Methods: MEFs were collected from mouse embryos via a previously published protocol. The cells were transduced with a single polycistronic viral vector encoding mouse cDNAs of Oct3/4, Sox2, Klf4 and c-Myc. Transduced cells were treated and sub-cultured with ESC medium. The cells were evaluated as iPSCs with specific morphology, and expression SSEA-1, Oct3/4, Sox2 and Nanog. In addition, they also were evaluated for pluripotency by assessing alkaline phosphatase (AP) activity and in vivo teratoma formation.
Results: Under the reprogrammed conditions, the transduced cells displayed a change in morphology, forming ESC-like clusters. These cell clusters strongly expressed pluripotent markers as well as ESC-specific genes. Furthermore, the colonies exhibited higher AP activity and formed teratomas when injected into the murine testis.
Conclusions: The study herein suggests that MEFs can be reprogrammed into iPSCs using a polycistronic viral vector encoding mouse cDNAs for Oct3/4, Sox2, Klf4 and c-Myc.
Evaluación de métodos de extracción para la obtención del ácido giberélico en semillas germinadas de maíz (Zea mays L.)
Authors: Rivera Juan David , Correa Yaned Milena , Penagos Juan Pablo
Published: June 2017

El maíz (Zea mays L.) es el segundo cereal de mayor cultivo a nivel mundial el cual es empleado como materia prima en diferentes industrias. Hasta el momento no se han encontrado reportes de la obtención del ácido giberélico (GA3) en esta planta. En el presente trabajo se compararon los métodos de extracción sólido-líquido por lixiviación y la extracción dinámica con disolvente asistida por sonicación (DSASE) para la obtención del GA3 a partir de semillas germinadas de maíz. Los factores trabajados en la extracción por lixiviación fueron el método físico, el solvente y el tiempo, mientras que los parámetros por DSASE fueron el flujo, el solvente y el tiempo. La mayor concentración del GA3 se obtuvo con el método DSASE (30,012 mg/kg), empleando como solvente acetonitrilo-ácido fórmico 5% (80:20, v:v) a un flujo de 0,4 mL/min y un tiempo de extracción de 25,0 min. La identificación y la cuantificación del GA3 se realizó mediante cromatografía líquida de alta eficiencia (HPLC) con detector de arreglo de diodos (DAD). Estos resultados evidenciaron que la DSASE es una alternativa novedosa para la obtención del GA3, dada su alta eficiencia, el bajo consumo de solvente y su simplicidad en la obtención del extracto.
Gyermekkori csuklótáji törések diagnosztikája ultrahanggal
Authors: Varga Marcell , Gáti Nikolett , Kalóz Erika , Bíró Zsuzsanna , Szeverényi Csenge , Kardos Dániel , Józsa Gergő
Published: June 2017

Abstract:

Introduction and aim: The aim of our prospective study was to evaluate the effectivity of sonographic diagnosis of pediatric wrist fractures and analyzing the results of two pediatric musculoskeletal centers. Method: Between 2011 January and 2015 December 467 children aged 0–15 with closed wrist injuries and open growth plates were sonographically and radiologically evaluated by an orthopaedic surgeon or a resident in trainee. Sonography was performed immediately after physical examination with linear probes of 7–14 Mhz frequency. Results were compared to conventional two plane wrist x-rays. Results: We found 97 sensitivity and 96 specificity of the sonographic evaluation. Fractures with dislocations and more serious clinical consequences were never missed. Conclusion: Musculoskeletal ultrasound is a very effective tool in daily routine for diagnosing or excluding pediatric wrist fractures. Orv Hetil. 2017; 158(24): 944–948.
A félelem és elkerülési hiedelmek krónikus fájdalomban. A FABQ kérdőív magyar változatának fordítása és validálása
Authors: Simoncsics Eszter , Stauder Adrienne
Published: June 2017

Abstract:

Introduction: Chronic low back pain is one of the top reasons for seeking medical advice. In the background of the dysfunction besides the somatic pain dysfunctional thinking, negative emotional states, or interpersonal problems can be identified as well. One of the most important factors making the rehabilitation difficult is the fear and avoidance of physical activity. Aim: The aim of the study was to adapt and validate the Fear Avoidance Beliefs Questionnaire (FABQ-H) in Hungarian. Methods: The FABQ (16 items) was translated into Hungarian and filled in by 90 patients suffering from low back pain for at least three months. For cross validation the FABQ-H results of 43 patients were compared with pain intensity the Oswestry Low Back Pain Questionnaire (ODI), the Roland–Morris Disability Questionnaire (RDQ), the Zung Depression Scale (Zung) and the Pain Catastrophising Scale (PCS). Results: The internal consistency of the FABQ-H was good: the Cronbach’s alpha was 0.8. Correlation analysis revealed that the FABQ showed significant correlation only with the Pain Catastrophising Scale (r = 0.373, p = 0.014). Conclusion: Our results confirm that the FABQ-H is a valid questionnaire that can be well implemented. Orv Hetil. 2017; 158(24): 949–955.
PENILAIAN PULAU KECIL SEBAGAI DASAR PENGEMBANGAN INVESTASI EKOWISATA (Studi Kasus Pulau Tidung Kecil, Kabupaten Kepulauan Seribu, DKI)
Authors: Widodo Puguh W. , Kurnia Rahmat , Sulistiono Sulistiono
Published: June 2017

Pulau Tidung Kecil merupakan pulau kecil tidak berpenduduk yang mempunyai potensi untuk pengembangan ekowisata. Penelitian ini bertujuan untuk menghitung indeks investasi ekowisata yang akan menentukan kelayakan investasi ekowisata pulau kecil. Metode yang digunakan pada penelitian ini adalah metode survey dengan menggunakan analisis indeks. Pegumpulan data primer dilakukan dengan observasi dan analisi peta, sedangkan data sekunder diperoleh melalui studi literatur. Hasil penelitian menunjukkan bahwa Pulau Tidung Kecil mempunyai nilai natural resources and geostrategic island index (NI) sebesar 3,67, govermenance index (GI) sebesar 4,20, infrastructure index (II) sebesar 3,22 dan, sosio economic and culture index(SI) sebesar 2,64. Sehingga dengan formulasi Small Island Investmen Index (SIII) didapatkan indeks investasi pulau sebesar 3,69. Dari nilai indeks tersebut, Pulau Tidung Kecil dapat dikategorikan kedalam pulau dengan kelayakan investasi siap. Sehingga Pulau Tidung Kecil bisa direkomendasikan sebagai pulau yang layak untuk pengembangan investasi ekowisata. (Assessment of Small Island As A Basis For Ecotourism Investment Developing(Case Study Tidung Kecil Island, Kepulauan Seribu Regency, DKI)Tidung Kecil Island is the unhabited small island that have ecotourism development potential. The aims of this study is to calculate the index of ecotourism investment that will determine the investment feasibility of small island ecotourism. Method used in this study was a survey method with index analysis. Primary data collection was done by observation and map analysis, while the secondary data obtained by study of literature. Results showed that the Tidung Kecil Island have a value of natural resources and geostrategic island index (NI) of 3.67, govermenance index (GI) of 4.20, infrastructure index (II) of 3.22 and, socio-economic and culture index (SI) of 2.64. So that with the Small Island Investment Index (SIII) formulation index obtained the investment index island of 3.69. From the index value Tidung Kecil Island can be categorized into the island with the feasibility of ready investment. So Tidung Kecil Island can be recommended as a viable island for the development of ecotourism investment.
JARINGAN KOMUNIKASI DALAM KEGIATAN PRODUKSI DAN PEMASARAN PADA PEMBUDIDAYA IKAN DI KABUPATEN KAMPAR, RIAU
Authors: Zulkarnain Zulkarnain , Lubis Djuara P. , Satria Arif , Hubeis Musa
Published: June 2017

Telah dilakukan penelitian tentang jaringan komunikasi pembudidaya ikan di kabupaten Kampar dalam melaksanakan kegiatan pembudidayaan ikan. Penelitian ini bertujuan untuk mengetahui sentral global, sentral lokal, kebersamaan dan keterhubungan komunikasi yang terjadi antar pembudidaya ikan di Kabupaten Kampar. Metode yang digunakan dalam penelitian ini adalah metode survey, pengumpulan data dilakukan dengan menggunakan teknik sampling intact system. Jaringan komunikasi yang dianalisis adalah sentral global, sentral lokal, kebersamaan dan keterhubungan dengan menggunakan Software UCINET 6. Hasil penelitian menjelaskan bahwa jaringan komunikasi diantara pembudidaya ikan terbentuk berdasarkan kedekatan tempat tinggal dan kesamaan karakter antar anggotanya. Struktur jaringan komunikasi produksi dan pemasaran dalam usaha budidaya perikanan merupakan jaringan yang membentuk interlock personal network (memusat). Jaringan komunikasi antar pembudidaya yang memusat ini memberi arti bahwa ada peran dominan individu diantara sesama pembudidaya ikan.  (The Communication Network In Production and Marketing Activities of Fish Farmers at Kampar Regency)The research about communication network in production and marketing activities of fish farmer was conducted in Koto Mesjid Village. The main objective of this research is to know the central global, central local, betweenees, and connectedness in communication networks of fish farmer in aquaculture activities. Field survey was applied by purposive sampling technique. Data was analzed by using sociometry analysis and Ucinet 6 software. The results of the study explained that the communication network of fish farmers in the village of Koto Mesjid formed by the proximity of residence and similarity of characters among its members. The structure of the communication network in the business of production and marketing of aquaculture is the network that forms the radial personal networks. Communication network between fish farmers who converged gives the sense that there is a dominant role among individuals between fish farmers.