bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatiotemporal Evolution of Gas in Transmission Fluid under Acoustic Cavitation Conditions
Authors: Wang Yongjin , Chen Yihong , Li Xiaolu , Xu Cangsu , Wei Wenjian , Zhao Jinhui , Jin Jie , Oppong Francis
Published: July 2024

The presence of gas in transmission fluid can disrupt the flow continuity, induce cavitation, and affect the transmission characteristics of the system. In this work, a gas void fraction model of gas–liquid two-phase flow in a transmission tube is established by taking ISO 4113 test oil, air, and vapor to accurately predict the occurrence, development, and end process of the cavitation zone as well as the transient change in gas void fraction. This model is based on the conservative homogeneous flow model, considering the temperature change caused by transmission fluid compression, and cavitation effects including air cavitation, vapor cavitation, and pseudo-cavitation. In this model, the pressure term is connected by the state equation of the gas–liquid mixture and can be applied to the closed hydrodynamic equations. The results show that in the pseudo-cavitation zone, the air void fraction decreases rapidly with pressure increasing, while in the transition zone from pseudo-cavitation to air cavitation, the air void fraction grows extremely faster and then increases slowly with decreasing pressure. However, in the vapor cavitation zone, the vapor void fraction rises slowly, grows rapidly, and then decreases, which is consistent with the explanation that rarefaction waves induce cavitation and compression waves reduce cavitation.
Anti-Inflammatory Benefits of Grape Pomace and Tomato Bioactives as Ingredients in Sun Oils against UV Radiation for Skin Protection
Authors: Kontaxi Nefeli-Ioanna , Panoutsopoulou Ellie , Ofrydopolou Anna , Tsoupras Alexandros
Published: July 2024

Daily exposure to solar light is not so harmless as previously thought, since UVA and UVB radiation has a significant effect on human health, by inducing skin-related inflammatory manifestations, such as hyperpigmentation, dermatitis, premature aging, erythema, and sunburn, among the most common skin conditions. At the same time, irreversible diseases such as various types of skin cancers, like basal cell carcinoma, melanoma, and squamous cell carcinoma, have begun to increase at dramatic rates, due to inflammatory and oxidative malignant effects of UV radiation exposure. Within this article, the health promoting effects of sunscreen for skin protection and especially of sunscreen enriched with natural antioxidant, anti-inflammatory, anti-allergic, and anti-cancer bio-functional ingredients are thoroughly reviewed. Emphasis is given to bioactives from grape by-products, such as bio-functional phytochemicals like flavonoids, stilbenes, and phenolic acids, as well as to tomato-derived bioactives like lycopene, which act either solely or synergistically and significantly enhance the antioxidant capacity of the composition product, as well as its photo-protection. The promising outcomes from in vitro studies and those reported from in vivo approaches, as well as the mechanisms of the obtained antioxidant, anti-inflammatory, anti-thrombotic, and antitumor action(s) of sunscreens infused with such natural bioactives, are also outlined. Limitations, such as the difficulties in incorporating lipophilic compounds like lycopene and/or amphiphilic phenolics into sunscreen cosmetic formulations, as well as future perspectives on the overall benefits that these compounds give to sunscreens, helping to improve properties such as smell, color, homogeneity, water resistance, and especially the Sun Protection Factor (SPF), are also discussed.
A Green Moment to Share: A Theatrical Laboratory to Explore Climate Crisis Possibilities within Single Moments
Authors: Bennett Nic , Alcantar Venese , Ravindran Tulasi , Chen Vanna , Terrell River , Dawson Kathryn
Published: July 2024

Many youth experience distress around the climate crisis. However, mainstream environmental messages ignore youth concerns, blame individuals, and suggest techno-fixes rather than addressing root causes. Young people need a way to productively process and collectively engage with their complex feelings about the climate crisis. During the spring of 2023, a group of university students facilitated a Research-based Theatre project to explore their relationship to climate and environmental justice as part of a biannual performance festival of student new work. Specifically, we used Theatre of the Oppressed techniques to slow down and embody participants’ struggles with environmental action. We argue that this process allowed participants to explore how and why they made sense of mainstream environmental messaging about the climate crisis. This paper offers a case study exploring how the interwoven themes of power, positionality, and agency emerged through embodied investigations during the early development of our Research-based Theatre performance. The paper concludes by discussing how Research-based Theatre can embrace a post-activist lens that supports the complexity of sense-making and troubles the over-emphasis on solution as the only response to environmental/climate crisis. Further, we argue for the kin-making possibilities that crisis can teach us when engaged through embodied exploration.
On Some Properties of the Equilateral Triangles with Vertices Located on the Support Sides of a Triangle
Authors: Andrica Dorin , Bagdasar Ovidiu
Published: July 2024

The possible positions of an equilateral triangle whose vertices are located on the support sides of a generic triangle are studied. Using complex coordinates, we show that there are infinitely many such configurations, then we prove that the centroids of these equilateral triangles are collinear, defining two lines perpendicular to the Euler’s line of the original triangle. Finally, we obtain the complex coordinates of the intersection points and study some particular cases.
Yadanziolide A Inhibits Proliferation and Induces Apoptosis of Hepatocellular Carcinoma via JAK-STAT Pathway: A Preclinical Study
Authors: Lin Lili , Chen Qi
Published: July 2024

Liver cancer is a significant global health concern, prompting the search for innovative therapeutic solutions. Yadanziolide A (Y-A), a natural derivative of Brucea javanica, has emerged as a promising candidate for cancer treatment; however, its efficacy and underlying mechanisms in liver cancer remain incompletely understood. In this study, we conducted a comprehensive evaluation of Y-A’s effects on liver cancer cells using a range of in vitro assays and an orthotopic liver cancer mouse model. Our findings reveal that Y-A exerts dose-dependent cytotoxic effects on liver cancer cells, significantly inhibiting proliferation, migration, and invasion at concentrations ≥ 0.1 μM. Furthermore, Y-A induces apoptosis, as evidenced by increased apoptotic cell populations and apoptosome formation. In vivo studies confirm that Y-A inhibits tumor growth and reduces liver damage in mouse models. Mechanistically, Y-A targets the TNF-α/STAT3 pathway, inhibiting STAT3 and JAK2 phosphorylation, thereby activating apoptotic pathways and suppressing tumor cell growth. These results suggest that Y-A has promising anticancer activity and potential utility in liver cancer therapy.
Retrospective Single-Center Case Study of Clinical Variables and the Degree of Actinic Elastosis Associated with Rare Skin Cancers
Authors: Drexler Konstantin , Bollmann Lara , Karrer Sigrid , Berneburg Mark , Haferkamp Sebastian , Niebel Dennis
Published: July 2024

(1) Background: Rare skin cancers include epithelial, neuroendocrine, and hematopoietic neoplasias as well as cutaneous sarcomas. Ultraviolet (UV) radiation and sunburns are important drivers for the incidence of certain cutaneous sarcomas; however, the pathogenetic role of UV light is less clear in rare skin cancers compared to keratinocyte cancer and melanoma. In this study, we compared the degree of actinic elastosis (AE) as a surrogate for lifetime UV exposure among selected rare skin cancers (atypical fibroxanthoma [AFX], pleomorphic dermal sarcoma [PDS], dermatofibrosarcoma protuberans [DFSP], Kaposi sarcoma [KS], Merkel cell carcinoma [MCC], and leiomyosarcoma [LMS]) while taking into account relevant clinical variables (age, sex, and body site). (2) Methods: We newly established a semi-quantitative score for the degree of AE ranging from 0 = none to 3 = total loss of elastic fibers (basophilic degeneration) and multiplied it by the perilesional vertical extent (depth), measured histometrically (tumor-associated elastosis grade (TEG)). We matched the TEG of n = 210 rare skin cancers from 210 patients with their clinical variables. (3) Results: TEG values were correlated with age and whether tumors arose on UV-exposed body sites. TEG values were significantly higher in AFX and PDS cases compared to all other analyzed rare skin cancer types. As expected, TEG values were low in DFSP and KS, while MCC cases exhibited intermediate TEG values. (4) Conclusions: High cumulative UV exposure is more strongly associated with AFX/PDS and MCC than with other rare skin cancers. These important results expand the available data associated with rare skin cancers while also offering insight into the value of differentiating among these tumor types based on their relationship with sun exposure, potentially informing preventative, diagnostic and/or therapeutic approaches.
Effect of Dietary Supplementation with Organic Silicon on the Growth Performance, Blood Biochemistry, Digestive Enzymes, Morphohistology, Intestinal Microbiota and Stress Resistance in Juvenile Hybrid Tilapia (Oreochromis mossambicus × Oreochromis niloticus)
Authors: Méndez-Martínez Yuniel , Valensuela-Barros Helen A. , Cruz-Quintana Yanis , Botello-León Aroldo , Muñoz-Mestanza Roberto D. , Orellana-Castro Grace L. , Angulo Carlos
Published: July 2024

In recent decades, interest has been aroused worldwide in the use of silicon in nutrition; however, information on its effect on nutrition and metabolism of fish is limited. The objective of the research was to evaluate the effect of dietary supplementation with organic silicon on the growth performance, blood biochemistry, digestive enzymes, morphohistology and intestinal microbiota and stress resistance in hybrid Tilapia (Oreochromis mossambicus × Oreochromis niloticus). Methodologically, six levels of organic silicon (DOS) [control (0), 10, 20, 30, 40 and 50 mg·kg−1] were used to feed juvenile fish (initial weight 7.51 ± 0.25 g) grown for eight weeks in 18 aquariums (15 fish/aquarium). The results indicated that growth performance showed differences (p < 0.05) for specific growth rate, feed conversion and survival. Triglycerides, cholesterol and glucose, transaminases and digestive enzymes were significantly influenced by DOS levels. The histological study confirmed that the administered diets did not cause damage and induced significant morphological changes in the proximal intestine. The 16S rRNA gene sequencing analysis of the gut microbiota showed a high diversity and richness of OTU/Chao-1, with Fusobacteria, Proteobacteria, Bacteroidetes and Acidobacteria predominating in the DOS treatments compared to the control (p < 0.05). Induction of hypoxia stress after the feeding period showed a significant relative survival rate of 83.33% in fish fed 50 mg·kg−1. It is concluded that the DOS treatments performed better than the control treatment in most of the variables analysed. DOS had no negative effects on the fish. The results showed that up to 50 mg·kg−1 DOS improved digestive, metabolic and growth performance in hybrid Tilapia.
Soil Microbial Community Structure and Carbon Stocks Following Fertilization with Organic Fertilizers and Biological Inputs
Authors: Sivojienė Diana , Masevičienė Aistė , Žičkienė Lina , Ražukas Almantas , Kačergius Audrius
Published: July 2024

The application of organic fertilizers and biological inputs to soil inevitably affects its quality, agrochemical indicators, and microbiota. Sustainable agriculture is based on continuously learning about how to properly manage available soil, water, and biological resources. The aim of the study was to determine changes in microorganism communities and carbon stocks in infertile soils for fertilization using different organic fertilizers and their combinations with bio-inputs. Genetic analysis of microorganism populations was performed using the NGS approach. Our study showed that the application of organic fertilizers affects the soil microbiota and the taxonomic structure of its communities. Specific groups of bacteria, such as Bacillota, were promoted by organic fertilization, meanwhile the abundance of Pseudomonadota and Ascomycota decreased in most treatments after the application of poultry manure. Metagenomic analysis confirmed that the use of bio-inputs increased the relative abundance of Trichoderma spp. fungi; meanwhile, a significant change was not found in the representatives of Azotobacter compared to the treatments where the bio-inputs were not used. The positive influence of fertilization appeared on all the studied agrochemical indicators. Higher concentrations of Corg and Nmin accumulated in the soil when we used granulated poultry manure, and pHKCl when we used cattle manure.
Effect of Liposomal Protium heptaphyllum (Alb.) March Extract in the Treatment of Obesity Induced by High-Calorie Diet
Authors: Patias Naiéle Sartori , de Queiroz Eveline Aparecida Isquierdo Fonseca , Ferrarini Stela Regina , Bomfim Gisele Facholi , Aguiar Danilo Henrique , Sinhorin Adilson Paulo , Bello Alexandre Aymberé , da Silva Geovana Vicentini Fazolo , Cavalheiro Larissa , Sinhorin Valéria Dornelles Gindri
Published: July 2024

Obesity, a chronic disease, resulted from excessive consumption of high-calorie foods, leading to an energy imbalance. Protium heptaphyllum (P. heptaphyllum) was used in folk medicine for its analgesic, anti-inflammatory, and healing properties. The association of the extract from P. heptaphyllum with nanotechnology was innovative for combining high technology with active ingredients that are easily accessible in the Amazon region. This study evaluated the effect of liposomes containing the ethyl acetate fraction of the crude extract of P. heptaphyllum leaves on obesity. Male Wistar rats treated with a high-calorie diet for 8 weeks to induce obesity received treatment with the liposome formulation containing P. heptaphyllum extract (1 mg/kg/day, via gavage) for 14 days. Morphological, metabolic, redox status, immunological, and histological parameters were evaluated in the adipose and liver tissue of the animals. The groups were divided as follows: C: control; P: liposomes containing extract; O: obese, and OP: obese + liposomes containing extract. The obesity model resulted in increases in body weight, caloric intake, body fat weight, and in the lipid profile. In adipose tissue, P decreased SOD (superoxide dismutase) activity in obese animals. In the liver, a positive modulation of the extract was observed in relation to glucose, amino acids, lactate, hepatoprotective action, and anti-inflammatory activity, with a decrease in interleukin 1β (IL-1β) in obese animals. The results showed an improvement in the functional and inflammatory aspects, but the treatment was not effective in alleviating general changes related to obesity, such as weight gain, fat, glucose, triglycerides, and inflammation in adipose tissue, highlighting the complexity of responses in different organs during obesity and treatment with P. heptaphyllum.
The Assessment of Sperm DNA Integrity: Implications for Assisted Reproductive Technology Fertility Outcomes across Livestock Species
Authors: Robertson Maya J. , Chambers Caitlin , Spanner Eloise A. , de Graaf Simon P. , Rickard Jessica P.
Published: July 2024

Sperm DNA integrity is increasingly considered a useful measure of semen quality in mammalian reproduction. However, the definition of DNA integrity, the ideal means by which it should be measured, and its predictive value for fertility remain a topic of much discussion. With an emphasis on livestock species, this review discusses the assays that have been developed to measure DNA integrity as well as their correlation with in vitro and in vivo fertility.
Recent Advances in Hydrogel Technology in Delivering Mesenchymal Stem Cell for Osteoarthritis Therapy
Authors: Wang Xiangjiang , He Wentao , Huang Hao , Han Jiali , Wang Ruren , Li Hongyi , Long Ying , Wang Guiqing , Han Xianjing
Published: July 2024

Osteoarthritis (OA), a chronic joint disease affecting over 500 million individuals globally, is characterized by the destruction of articular cartilage and joint inflammation. Conventional treatments are insufficient for repairing damaged joint tissue, necessitating novel therapeutic approaches. Mesenchymal stem cells (MSCs), with their potential for differentiation and self-renewal, hold great promise as a treatment for OA. However, challenges such as MSC viability and apoptosis in the ischemic joint environment hinder their therapeutic effectiveness. Hydrogels with biocompatibility and degradability offer a three-dimensional scaffold that support cell viability and differentiation, making them ideal for MSC delivery in OA treatment. This review discusses the pathological features of OA, the properties of MSCs, the challenges associated with MSC therapy, and methods for hydrogel preparation and functionalization. Furthermore, it highlights the advantages of hydrogel-based MSC delivery systems while providing insights into future research directions and the clinical potential of this approach.
Altered Body Composition and Cytokine Production in Patients with Elevated HOMA-IR after SARS-CoV-2 Infection: A 12-Month Longitudinal Study
Authors: Kartika Rona , Subekti Imam , Kurniawan Farid , Wafa Syahidatul , Pradnjaparamita Tika , Tahapary Dicky L. , Wibowo Heri
Published: July 2024

Altered body composition and cytokine production due to SARS-CoV-2 antigens may affect homeostasis model assessment for insulin resistance (HOMA-IR) after SARS-CoV-2 infection. To elucidate this phenomenon, we conducted a longitudinal study involving 47 COVID-19 patients, who were followed up for 12 months. During recruitment, body composition and glucose indices were measured, and heparin blood samples were collected for measuring cytokine production. HOMA-IR was considered an elevated or non-elevated group based on the ratio between HOMA-IR at 12 months and 1 month of convalescence. Those with elevated HOMA-IR had a significantly higher body mass index, body fat percentage, and visceral fat rating and had a lower lean mass and lean/fat mass ratio than their counterparts. During the convalescent period, the elevated HOMA-IR group had lower TNFα, IFNγ, IL-2, IL-10, and granzyme B expression levels but had higher TNFα/IL-10, IFNγ/IL-10, IL-2/IL-10, and granzyme B/IL-10 ratios than the other group. The reduced cytokine production and pro-/anti-inflammatory imbalance in patients with elevated HOMA-IR may suggest immune cell dysfunction toward SARS-CoV-2. Patients with elevated HOMA-IR after SARS-CoV-2 infection may experience an increase in BMI and body fat percentage, leading to increased immune dysfunction and chronic inflammatory condition. A nutritional approach and promotion of physical activity may help reduce HOMA-IR and ameliorate glucose indices in these patients.
Preoperative Ultrasonography Predicts Level II Lymph Node Metastasis in N1b Papillary Thyroid Carcinoma: Implications for Surgical Planning
Authors: Eun Na Lae , Kim Jeong-Ah , Lee Yangkyu , Youk Ji Hyun , Yun Hyeok Jun , Chang Hojin , Kim Seok-Mo , Lee Yong Sang , Chang Hang-Seok , Yang Hyejin , Jeon Soyoung , Son Eun Ju
Published: July 2024

Purpose: To investigate whether preoperative ultrasonographic (US) features of the index cancer and metastatic lymph nodes (LNs) are associated with level II LN metastasis in N1b papillary rmfthyroid carcinoma (PTC) patients. Materials and methods: We enrolled 517 patients (mean age, 42 [range, 6–80] years) who underwent total thyroidectomy and lateral compartment LN dissection between January 2009 and December 2015. We reviewed the clinicopathologic and US features of the index cancer and metastatic LNs in the lateral neck. Logistic regression analysis was performed to analyze features associated with level II LN metastasis. Results: Among the patients, 196 (37.9%) had level II metastasis on final pathology. In the preoperative model, larger tumor size (odds ratios [ORs], 1.031; 95% confidence interval [CI]: 1.011–1.051, p = 0.002), nonparallel tumor shape (OR, 1.963; 95% CI: 1.322–2.915, p = 0.001), multilevel LN involvement (OR, 1.906; 95% CI: 1.242–2.925, p = 0.003), and level III involvement (OR, 1.867; 95% CI: 1.223–2.850, p = 0.004), were independently associated with level II LN metastasis. In the postoperative model, non-conventional pathology remained a significant predictor for level II LN metastasis (OR, 1.951; 95% CI: 1.121–3.396; p = 0.018), alongside the presence of extrathyroidal extension (OR, 1.867; 95% CI: 1.060–3.331; p = 0.031), and higher LN ratio (OR, 1.057; 95% CI: 1.039–1.076; p < 0.001). Conclusions: Preoperative US features of the index tumor and LN may be helpful in guiding surgery in N1b PTC. These findings could enhance preoperative planning and decision-making, potentially reducing surgical morbidities by identifying those at higher risk of level II LN metastasis and tailoring surgical approaches accordingly.
Changes of Target Essential Trace Elements in Multiple Sclerosis: A Systematic Review and Meta-Analysis
Authors: Stojsavljević Aleksandar , Jagodić Jovana , Perović Tatjana , Manojlović Dragan , Pavlović Slađan
Published: July 2024

(1) Background: Multiple sclerosis (MS) is a chronic, complex, and demyelinating disease closely associated with altered levels of trace elements. Although the first studies into the role of trace elements in MS were published in the 1970s, for five decades it has remained unknown whether trace elements can be part of this heterogeneous neurological disease. (2) Materials and methods: To drive toward at a potential solution, we conducted a systematic review and meta-analysis to elucidate whether there were differences in circulating levels of neurologically important essential trace elements (Zn, Fe, Co, Cu, Mn, and Se) between MS cases and controls. (3) Results: This study revealed significantly lower serum/plasma Zn and Fe levels and higher Cu levels in MS-affected individuals compared to controls. At the same time, no significant differences were found between the MS cases and controls regarding their serum/plasma levels of Co, Mn, or Se. Thus, the loss of Fe and Zn should be considered in supplementation/nutrition strategies for MS patients. On the other hand, since high serum Cu levels indicate a burden on the bloodstreams of MS patients, Cu should be excluded from mineral supplement strategies. Furthermore, all three trace elements (Fe, Zn, and Cu) should be considered from an etiological point of view, and, most importantly, their levels in the bloodstreams of MS patients should be monitored. (4) Conclusions: This study highlights the way for personalized and targeted strategies in the management of MS.
Rasagiline Exerts Neuroprotection towards Oxygen–Glucose-Deprivation/Reoxygenation-Induced GAPDH-Mediated Cell Death by Activating Akt/Nrf2 Signaling
Authors: Lecht Shimon , Lahiani Adi , Klazas Michal , Naamneh Majdi Saleem , Rubin Limor , Dong Jiayi , Zheng Wenhua , Lazarovici Philip
Published: July 2024

Rasagiline (Azilect®) is a selective monoamine oxidase B (MAO-B) inhibitor that provides symptomatic benefits in Parkinson’s disease (PD) treatment and has been found to exert preclinical neuroprotective effects. Here, we investigated the neuroprotective signaling pathways of acute rasagiline treatment for 22 h in PC12 neuronal cultures exposed to oxygen–glucose deprivation (OGD) for 4 h, followed by 18 h of reoxygenation (R), causing 40% aponecrotic cell death. In this study, 3–10 µM rasagiline induced dose-dependent neuroprotection of 20–80%, reduced the production of the neurotoxic reactive oxygen species by 15%, and reduced the nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by 75–90%. In addition, 10 µM rasagiline increased protein kinase B (Akt) phosphorylation by 50% and decreased the protein expression of the ischemia-induced α-synuclein protein by 50% in correlation with the neuroprotective effect. Treatment with 1–5 µM rasagiline induced nuclear shuttling of transcription factor Nrf2 by 40–90% and increased the mRNA levels of the antioxidant enzymes heme oxygenase-1, (NAD (P) H- quinone dehydrogenase, and catalase by 1.8–2.0-fold compared to OGD/R insult. These results indicate that rasagiline provides neuroprotection to the ischemic neuronal cultures through the inhibition of α-synuclein and GAPDH-mediated aponecrotic cell death, as well as via mitochondrial protection, by increasing mitochondria-specific antioxidant enzymes through a mechanism involving the Akt/Nrf2 redox-signaling pathway. These findings may be exploited for neuroprotective drug development in PD and stroke therapy.
Gray-Scale Median in Patients with Symptomatic and Asymptomatic Carotid Atherosclerosis—Risk Factors and Diagnostic Potential
Authors: Płoński Adam , Pawlak Dariusz , Płoński Adam F. , Głowiński Jerzy , Madycki Grzegorz , Pawlak Krystyna
Published: July 2024

Background: The identification of clinical factors affecting the gray-scale median (GSM) and determination of GSM diagnostic utility for differentiating between symptomatic and asymptomatic internal carotid artery (ICA) stenosis. Methods: This study included 45 patients with asymptomatic and 40 patients with symptomatic ICA stenosis undergoing carotid endarterectomy (CEA). Echolucency of carotid plaque was determined using computerized techniques for the GSM analysis. Study groups were compared in terms of clinical risk factors, coexisting comorbidities, and used pharmacotherapy. Results: Mean GSM values in the symptomatic group were significantly lower than in the asymptomatic group (p < 0.001). Both in the univariate as well as in the multiple regression analysis, GSM was significantly correlated with D-dimers and fasting plasma glucose levels and tended to correlate with β-adrenoceptor antagonist use in the symptomatic group. In asymptomatic patients, GSM was associated with the presence of grade 2 and grade 3 hypertension, and tended to correlate with the use of metformin, sulfonylureas, and statin. Independent factors for GSM in this group remained as grade 3 hypertension and statin’s therapy. The receiver operating characteristic (ROC) analysis revealed that GSM differentiated symptomatic from asymptomatic ICA stenosis with sensitivity and specificity of 73% and 80%, respectively. Conclusion: The completely diverse clinical parameters may affect GSM in symptomatic and asymptomatic patients undergoing CEA, whose clinical characteristics were similar in terms of most of the compared parameters. GSM may be a clinically useful parameter for differentiating between symptomatic and asymptomatic ICA stenosis.
Aerodynamic Effects of Time-Varying Corrugations on Dragonfly Wings in Flapping Flight
Authors: Hou Dan , Tan Biao , Shi Binghao , Zhong Zheng
Published: July 2024

The aerodynamic effects of wing corrugation on insect flight have received widespread attention. However, there has hardly been any specific focus on dynamic changes to corrugation angle in the models. The flexible vein joints containing resilin in the wings of dragonflies and damselflies enable the longitudinal veins to rotate and thereby change the corrugation angles throughout flapping cycles. Therefore, a two-dimensional corrugated airfoil with time-varying corrugation angles is proposed and the aerodynamic performance is evaluated in terms of aerodynamic force, power and efficiency. The results indicate that the airfoil with time-varying corrugations outperforms the rigid one in terms of enhancing thrust and reducing power consumption. The aerodynamic performance of time-varying corrugated airfoils is optimal when the angle varies in a specific range, and an excessively large angle variation may have negative effects. In addition, excessive height or a negative leading edge of the corrugation can lead to a reduction in the thrust. A design concept for the 2D airfoil with time-varying corrugations is provided and the findings are of significance for enhancing the aerodynamic performance of biomimetic flexible flapping-wing vehicles.
Editorial for the Special Issue: “Biomimicry and Functional Materials—First, Second, and Third Editions”
Authors: Sut Tun Naw , Yoon Bo Kyeong
Published: July 2024

Nature has long been a source of inspiration for innovation in materials science [...]
Ultrasonic Sensor: A Fast and Non-Destructive System to Measure the Viscosity and Density of Molecular Fluids
Authors: Muñoz Romina , Fuentealba Juan-Francisco , Michea Sebastián , Santana Paula A. , Martinez Juan Ignacio , Casanova-Morales Nathalie , Salinas-Barrera Vicente
Published: July 2024

This study presents the design and development of an ultrasonic sensor as a fundamental tool for characterizing the properties of fluids and biofluids. The analysis primarily focuses on measuring the electrical parameters of the system, which correlate with the density and viscosity of the solutions, in sample volumes of microliters and with high temporal resolution (up to 1 data point per second). The use of this sensor allows the fast and non-destructive evaluation of the viscosity and density of fluids deposited on its free surface. The measurements are based on obtaining the impedance versus frequency curve and the phase difference curve (between current and voltage) versus frequency. In this way, characteristic parameters of the transducer, such as the resonance frequency, phase, minimum impedance, and the quality factor of the resonant system, can characterize variations in density and viscosity in the fluid under study. The results obtained revealed the sensor’s ability to identify two parameters sensitive to viscosity and two parameters sensitive to density. As a proof of concept, the unfolding of the bovine albumin protein was studied, resulting in a curve that reflects its unfolding kinetics in the presence of urea.
The Role of Different Clay Types in Achieving Low-Carbon 3D Printed Concretes
Authors: Hanratty Niall , Khan Mehran , McNally Ciaran
Published: July 2024

Concrete 3D printing, an innovative construction technology, offers reduced material waste, increased construction speed, and the ability to create complex and customized shapes that are challenging to achieve with traditional methods. This study delves into the unique fresh-state performance required for 3D printing concrete, discussing buildability, extrudability, and shape retention in terms of concrete rheology, which can be modified using admixtures. Currently most 3D printing concretes feature high cement contents, with little use of secondary cementitious materials. This leads to high embodied carbon, and addressing this is a fundamental objective of this work. The research identifies attapulgite, bentonite, and sepiolite clay as potential concrete admixtures to tailor concrete rheology. Eight low-carbon concrete mixes are designed to incorporate GGBS at a 50% replacement level and are used to measure the influence of each clay on the concrete rheology at varying dosages. A comprehensive rheological test protocol is designed and carried out on all mixes, together with other tests including slump-flow and compression strength. The objective is to determine the applicability of each clay in improving the printability of low-carbon concrete. The findings reveal that at a dosage of 0.5%, sepiolite was seen to improve static yield stress, dynamic yield stress, and rate of re-flocculation, resulting in improved printability. The addition of attapulgite and sepiolite at a dosage of 0.5% by mass of binder increased compressive strength significantly; bentonite had very little influence. These gains are not repeated at 1% clay content, indicating that there may be an optimum clay content. The results are considered encouraging and show the potential of these clays to enhance the performance of low-carbon concrete in 3D printing applications.
Numerical Analysis of the Single-Directionally Misaligned Segment Behavior of Hydraulic TBM Tunnel
Authors: Li Fenglan , Si Pengcheng , He Yintao , Wang Hui , Zhang Zhixiao , Zhao Shunbo
Published: July 2024

The misalignment of segments in installation is a common issue in the construction of TBM tunnels. This raises a question of whether misalignment affects the operation safety of a hydraulic TBM tunnel. Using a water transfer engineering project as an example, this paper built a three-dimensional finite element model composited with segment, grout layer and surrounding rock for the numerical analysis of the behavior of single-directionally misaligned segments. The crown or invert segment was separately misaligned towards to the center of segment ring in a value of 5 mm, 10 mm, 20 mm, 30 mm or 40 mm. The strength grade of the segment concrete was C50. A weaker surrounding rock composed of V-class rock was considered for the tunnel. The results indicate that the misalignment of the crown or invert segment, respectively, creates the tensile stress in the inner surface of the corresponding segment, the tensile stress will be over the limit of C50 concrete when the misalignment is over 30 mm, indicating a risk of concrete cracking. The contact surfaces of the segment ring basically remain in compression, and the locating pins between the segment rings exhibit an evident increase in tensile stress at misaligned positions. The key points that can be obtained from this study are that a special supervision is needed to ensure the accuracy of segment installation, and strengthening measures are needed for existing misaligned segments.
Study on Interprovincial Equity and the Decoupling of Carbon Emissions in the Construction Industry—A Case Study in China
Authors: Dai Chao , Tan Yuan , Cao Shuangping , Liao Hong , Pu Jie , Cai Weiguang
Published: July 2024

Interprovincial disparities in carbon emissions from the construction industry (CECI) are an important challenge for future emissions reductions. Based on the CECI data of 30 provinces in China from 2010 to 2020, the interprovincial equity and decoupling of CECI were examined in this study. The conclusions are as follows: (1): The main CECI growth regions were the eastern Bohai Rim region and the Pearl River Delta region. Heilongjiang basically achieved a CECI carbon peak in 2016. (2) The three northeastern provinces and western provinces were the main high–high and low–low aggregation areas, respectively. The greatest degree of inequality was found in the western provinces. The inequality between the eastern and western areas was the largest, while the inequality between the central and western areas was the smallest. The inequality in CECI in the north–south region decreased year by year. (3) The decoupling status of Shandong and some western provinces has significantly worsened, while the decoupling status of Sichuan, Yunnan, and some eastern developed provinces has been improving. These conclusions will contribute to the improvement of regional emission reduction strategies.
Creating an Efficient Public–Private Partnership Bundle: An Empirical Study
Authors: Teo Pauline
Published: July 2024

Public–Private Partnerships have been implemented globally as a key procurement strategy for addressing the issue of funding gaps amidst the immense pressure to deliver new major infrastructure projects. However, in current practice, procurement selection is applied to the entire bundle of project activities. This often leads to unduly large bundles of externalized project activities that create unduly large PPP contracts and attempt to transfer too much risk. To address this gap, this paper presents the development and testing of an implementable model that embodies a range of microeconomic theories—namely, transaction cost and resource-based theories—and property rights theory. This paper presents the first empirical testing of this model based on two road and two health projects, using competition as an independent measure of the validity of the recommended procurement strategy. The results provide compelling evidence that a rigorous application of the model will enable a substantial improvement of existing procurement approaches, such as identifying the most suitable bundle to be procured using a PPP approach.
Optimal Replacement Ratio of Recycled Concrete Aggregate Balancing Mechanical Performance with Sustainability: A Review
Authors: Lu Linfeng
Published: July 2024

Significant construction and demolition waste (CDW) is produced by many useless concrete buildings, bridges, airports, highways, railways, industrial mining, etc. The rising need for new construction has increased the use of natural materials, impacting the ecosystem and incurring high costs from mining natural aggregates (NA) and processing CDW. The concept and implementation of recycled aggregate concrete (RAC) offer a sustainable solution for the concrete industry. Crushed concrete, made from recycled concrete, can be used instead of natural aggregates in structural concrete. This sustainable byproduct, recycled concrete aggregate (RCA), has the potential to replace natural aggregate. This paper examines the benefits of RAC from economic, social, environmental, and technological perspectives and discusses the replacement ratio (RR)—the weight percentage of natural aggregate replaced by recycled aggregate—which is crucial to RAC performance. A collection of used data on mechanical properties and economic performance, national specifications, standards, and guidelines is reviewed to determine the optimal replacement ratio for RCA, which was found to be 20%. Finally, we discuss the challenges and future of using RAC in structural concrete.
Evaluating Stakeholders’ Decisions in a Blockchain-Based Recycling Construction Waste Project: A Hybrid Evolutionary Game and System Dynamics Approach
Authors: Lin Yi-Hsin , Wang Jian , Niu Deshuang , Nwetlawung Zilefac Ebenezer
Published: July 2024

To promote efficient construction waste recycling and reuse, a novel waste management approach based on blockchain technology was introduced to the industry. However, adopting blockchain platforms in construction waste recycling and reuse may impact the behavioral strategies of stakeholders and impede the prediction of the specific impacts of stakeholders’ decisions. Accordingly, this study addresses two primary questions: (1) What are the collaborative framework and the behavioral evolution trends of multiple stakeholders within the context of blockchain? (2) How can the behavioral strategies of multiple stakeholders be systematically coordinated to achieve efficient construction waste recycling and reuse driven by blockchain? To answer these questions, a tripartite game model combined with system dynamics was constructed. In this model, we aimed to elucidate the internal organizational framework, analyze the dynamic evolution process, and assess the influence of decisions made by multiple stakeholders at the individual level. It also offers corresponding policy recommendations for efficient construction waste recycling and reuse driven by blockchain at the system level. This study offers three innovations. First, it considers the decision-making of multiple stakeholders as an interdependent and coevolutionary process to overcome the defects of analyzing only one type of participant. Second, in contrast to the static analysis method, it employs a dynamic system approach to deeply analyze the evolving structures of blockchain-based projects. Third, it provides a theoretical framework for the practical implementation of blockchain-driven platforms in managing construction waste recycling and reuse, thus fostering effective policy development and management practices. This framework aims to promote sustainable development in construction waste recycling and reuse projects in China as well as globally.
Conceptual Framework of Information Flow Synchronization Throughout the Building Lifecycle
Authors: Raitviir Christopher-Robin , Lill Irene
Published: July 2024

The construction industry’s reliance on traditional methods and fragmented workflows results in significant information loss, inefficiencies, increased costs, and errors. This study addresses these issues by integrating comprehensive urban planning with building information modeling (BIM) to create a seamless information flow throughout the building lifecycle. We propose a holistic framework that synchronizes data from planning to demolition, incorporating national and municipal digital twins. An imperative literature review and analysis of international best practices were conducted to develop a conceptual framework aimed at improving data accuracy and interoperability. Our findings underscore the importance of adopting open standards such as Industry Foundation Classes (IFC) and CityGML for effective information exchange. By implementing an information model (IM)-based approach in urban planning and public sector permit processes, project timelines can be streamlined, and regulatory compliance enhanced. This study concludes that continuous, integrated information flow facilitates more efficient, cost-effective construction practices and improved decision-making. Furthermore, this research illustrates the potential of digital twin technology to revolutionize the construction industry by enabling real-time data integration and fostering stakeholder collaboration, ultimately offering a robust framework for practitioners, and significantly enhancing the efficiency and accuracy of construction processes.
Circulating Polymorphonuclear Myeloid-Derived Suppressor Cells (PMN-MDSCs) Have a Biological Role in Patients with Primary Myelofibrosis
Authors: Campanelli Rita , Carolei Adriana , Catarsi Paolo , Abbà Carlotta , Boveri Emanuela , Paulli Marco , Gentile Raffaele , Morosini Monica , Albertini Riccardo , Mantovani Stefania , Massa Margherita , Barosi Giovanni , Rosti Vittorio
Published: July 2024

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by a chronic inflammatory state that plays a relevant role in the disease pathogenesis (as proven by high levels of inflammatory cytokines with prognostic significance and by a persistent oxidative stress) and by extensive neoangiogenesis in bone marrow (BM) and spleen. Myeloid-derived suppressor cells (MDSCs) are immature cells that expand in patients with cancer, sepsis or chronic inflammation, favoring tumor onset and progression mainly through the decrease in immune surveillance and the promotion of neoangiogenesis. In this paper, we evaluated the presence of circulating MDSCs in PMF patients, the plasmatic factors involved in their mobilization/expansion and the correlations with laboratory, genetic and clinical parameters. The data indicated that MDSCs could have a relevant role in PMF as a new pathogenic mechanism contributing to explaining the phenotypic diversity observed during the clinical course of the disease, or a potential new target for personalized treatment.
The Prognostic Impact of HER2-Low and Menopausal Status in Triple-Negative Breast Cancer
Authors: Park Woong Ki , Nam Seok Jin , Kim Seok Won , Lee Jeong Eon , Yu Jonghan , Lee Se Kyung , Ryu Jai Min , Chae Byung Joo
Published: July 2024

TNBC is noted for its aggressive behavior and poor prognosis. Recently developed HER2 target agents have shown potential benefit even in HER2-low expressing breast cancers. This study retrospectively analyzed 2542 non-metastatic TNBC patients from 2008 to 2020, revealing that 26.0% were HER2-low. Data on demographics, tumor characteristics, pathologic complete response (pCR) rates and disease-free survival (DFS), distant metastasis-free survival (DMFS), overall survival (OS), and breast cancer-specific survival (BCSS) were analyzed. The HER2-low group, compared to the HER2-0 group, showed significantly better DFS, DMFS, OS, BCSS (p = 0.0072, p = 0.0096, p = 0.0180, and p = 0.0001, respectively) with older age and higher rates of postmenopausal status (p < 0.0001). No significant differences in pCR rates were observed. Multivariate analyses identified HER2 status as a significant prognostic factor for DFS (p = 0.048), DMFS (p = 0.018), OS (p = 0.049), and BCSS (p = 0.008). Subgroup analysis revealed that these effects varied with menopausal status, showing more pronounced benefits in postmenopausal women. Our findings suggest that HER2-low TNBC patients exhibit a distinct clinical profile and improved survival compared to HER2-0 TNBC patients, especially in postmenopausal patients. Further research on estrogen and HER2 interaction is needed.
State of the Art in Molecular Catalysis in Europe
Authors: Redshaw Carl
Published: July 2024

In this editorial, I would like to provide an overview of the eleven contributions to the Special Issue entitled “State of the Art in Molecular Catalysis in Europe”, which is part of the Organic and Polymer Chemistry Section of Catalysts [...]
Catalysis on Zeolites and Zeolite-like Materials II
Authors: Reschetilowski Wladimir
Published: July 2024

This Special Issue is a continuation of the previous successful Special Issue, “Catalysis on Zeolites and Zeolite-Like Materials”, which presented the latest developments and advances in the synthesis, characterization, and application of zeolites and zeolite-like materials as catalysts by renowned scientists [...]
Single-Nucleotide Polymorphisms of TAS2R46 Affect the Receptor Downstream Calcium Regulation in Histamine-Challenged Cells
Authors: Lecchi Giulia , Mocchetti Chiara , Tunesi Davide , Berto Arianna , Balasubramanian Hari Baskar , Biswas Sima , Bagchi Angshuman , Pollastro Federica , Fresu Luigia Grazia , Talmon Maria
Published: July 2024

Bitter taste receptors (TAS2Rs) expressed in extraoral tissues represent a whole-body sensory system, whose role and mechanisms could be of interest for the identification of new therapeutic targets. It is known that TAS2R46s in pre-contracted airway smooth muscle cells increase mitochondrial calcium uptake, leading to bronchodilation, and that several SNPs have been identified in its gene sequence. There are very few reports on the structure–function analysis of TAS2Rs. Thus, we delved into the subject by using mutagenesis and in silico studies. We generated a cellular model that expresses native TAS2R46 to evaluate the influence of the four most common SNPs on calcium fluxes following the activation of the receptor by its specific ligand absinthin. Then, docking studies were conducted to correlate the calcium flux results to the structural mutation. The analysed SNPs differently modulate the TAS2R46 signal cascade according to the altered protein domain. In particular, the SNP in the sixth transmembrane domain of the receptors did not modulate calcium homeostasis, while the SNPs in the sequence coding for the fourth transmembrane domain completely abolished the mitochondrial calcium uptake. In conclusion, these results indicate the fourth transmembrane domain of TAS2R46 is critical for the intrinsic receptor activity.