bluuebunny/crossref_metadata_2025 huggingface dataset:
An integrative Bayesian network approach to highlight key drivers in systemic lupus erythematosus
Authors: Maleknia Samaneh , Salehi Zahra , Sharifi-Zarchi Ali , Rezaei-Tabar Vhid , Kavousi Kaveh
Published: January 2020

Background: To perceive a comprehensive illustration of the systemic lupus erythematosus (SLE), as a complex and multifactorial disease, draw a biological challenge. Dealing with this challenge needs employing sophisticated bioinformatics algorithms to discover the unknown aspects. This study aimed to distinguish key molecular characteristics of SLE pathogenesis, which may serve as effective targets for therapeutic intervention. Methods: In the present study, six gene expression microarray datasets included SLE patients (n=220) and healthy controls (n=135) were collected. We integrated the datasets by cross-platform normalization. Subsequently, through BNrich method, the structures of Bayesian networks (BNs) were extracted from SLE, TCR and BCR signaling pathways and the parameters of BNs were estimated using integrated datasets. Finally, a meta-analysis was performed to distinguish the signaling pathways alterations in the SLE pathogenesis. Results: We identified the most dysregulated genes involved in the clearance mechanism (most inhibition in MACROH2A2 and H4C9, most activation in SNRPD3, MACROH2A1 and RO60). Augmented autoantigens presentation by MHCII (HLA-DQA1, HLA-DOB and HLA-DPB1) and CD80 and CD86 to CD28 biological functions were also observed. The increased expression of FCGR1A, C8G, C7 and C9 genes and decreasing biological functions in edges from C1R and C1S to C2 and from C1R to C4B, all involved in end-organ damage, were detected. On the other hand, many of subnetworks alterations of TCR and BCR reported in previous research (PI3K/AKT, MAPK, AP-1 transcription factor). Conclusions: Overall, the BNrich as a hybridized network construction method, which integrates intergenic relations inferred from signaling pathways and gene expression profiling, can be employed to study complex diseases. Here we applied BNrich and highlighted significant genes and intergenic relationships and systemic alterations in SLE, TCR and BCR signaling pathways.
Microbial mats in the Turks and Caicos Islands reveal diversity and evolution of phototrophy in the Chloroflexota order Aggregatilineales
Authors: Ward Lewis M , Lingappa Ush , Grotzinger John , Fischer Woodward
Published: January 2020

Genome-resolved metagenomic sequencing approaches have led to a substantial increase in the recognized diversity of microorganisms; this included the discovery of novel metabolic pathways in previously recognized clades, and has enabled a more accurate determination of the extant distribution of key metabolisms and how they evolved over Earth history. Here, we present metagenome-assembled genomes of members of the Chloroflexota (formerly Chloroflexi or Green Nonsulfur Bacteria) order Aggregatilineales (formerly SBR1031 or Thermofonsia) discovered from sequencing of thick and expansive microbial mats present in an intertidal lagoon on Little Ambergris Cay in the Turks and Caicos Islands. These taxa included multiple new lineages of Type 2 reaction center-containing phototrophs that were not closely related to previously described phototrophic Chloroflexota—revealing a rich and intricate history of horizontal gene transfer and the evolution of phototrophy and other core metabolic pathways within this widespread phylum.
Identification of phosphorus stress related proteins in the seedlings of Dongxiang wild rice (Oryza rufipogon Griff.) using label-free quantitative proteomic analysis
Authors: Deng Qianwen , Bai Liweidan , Dai Liangfang , Chen Yaling , Fang Jun , Xie Jiankun , Luo Xiangdong
Published: January 2020

Background: The lack of available phosphorus (P) in soil is one of the important factors restricting rice growth. Previous studies indicated that Dongxiang wild rice (DXWR, O. rufipogon Griff.) was resistant to low-P stress. So far, the research of resistance mechanism in DXWR was very limited.Results: The results showed that 3589 significant differential accumulation proteins were identified between low P and the normal P treated root samples. 60 up-regulated and 15 down-regulated proteins were identified with ≥ 1.5-fold changes as an additional standard. Furthermore, among 75 significantly different expression proteins (SDEPs), 24 proteins also detected in previous transcriptome dataset verified by qRT-PCR, including OsPT2, OsPT8, OsPAP10c, OsPAP10a and OsPHF1. Through comprehensive analysis, it was found that DXWR could increase PAPs, membrane location of PTs, rhizosphere area, alternative splicing and decrease ROS activity to deal with low-P stress. Moreover, among the genes corresponding to 75 SDEPs, 7 uncharacterized genes were located in previous P related QTL intervals, of which two genes (LOC_Os12g09620 and LOC_Os03g40670) have been detected at both transcriptome and proteome levels. In addition, the expression patterns of OsPHR1, OsPHR2, OsPHO1 and NAT-OsPHO1 in DXWR were different in cultivated rice, suggesting that the response mechanism of some low-P tolerance in DXWR might be different from that in cultivated rice.Conclusions: This study screened out some candidate genes for low-P resistance and preliminarily verified that there might be a different low-P response mechanism in DXWR than in cultivated rice, which would provide insights in cloning the P-deficiency genes from wild rice, as well as elucidating the molecular mechanism of low-P resistance in DXWR.
Disequilibrium evolution of Fructose-1,6-bisphosphatase gene family leads to their functional biodiversity in Gossypium species
Authors: Ge Qun , Cūi Yànli , Lǐ Jùnwén , Gōng Jǔwǔ , Lú Quánwěi , Lǐ Péngtāo , Shí Yùzhēn , Shāng Hǎihóng , Liú Àiyīng , Dèng Xiǎoyīng , Pān Jìngtāo , Chén Qúanjiā , Yuán Yǒulù , Gǒng Wànkuí
Published: January 2020

Background：Fructose-1,6-bisphosphatase (FBP) is a key enzyme in plant sucrose synthesis pathway in Calvin cycle and plays an important role in photosynthesis regulation in green plants. However, no systemic analysis of the FBPs has been reported in Gossypium species.Results：A total of 41 FBP genes from four Gossypium species were identified and analyzed. The FBP genes were assorted into two groups and 7 subgroups. The results revealed that FBP family genes were under a purifying selection pressure which rendered FBP family members a conserved evolution pattern and that there was no tandem and fragmental DNA duplication in FBP family genes. Collinearity analysis revealed that a FBP gene was located in the translocated DNA fragment and the whole FBP gene family was under a disequilibrium evolution pattern which led to a faster evolution progress of the members in G. barbadense and in At subgenome than those in the rest Gossypium species and in Dt subgenome, respectively of this study. Through RNA-seq analyses and qRT-PCR verifications, different FBP genes have diversified biological functions in cotton fiber development (2 genes in 0 DPA and 1DPA ovules and 4 genes in 20-25 DPA fibers), and in plant responses to Verticillium wilt onset (2 genes) and to salt stress (8 genes).Conclusion: The FBP gene family displayed disequilibrium evolution pattern in Gossypium species, which render them diversified functions affecting not only fiber development, but also responses to the Verticillium wilt and the salt stress. All the findings provided the foundation for further study of the function of the FBP genes in cotton fiber development and in environmental adaptability.
If you can’t breathe through your nose
Authors: Kalinina N.
Published: January 2020

According to figures  provided by the  Ministry  of Health, the  autumn-winter period is characterized  by the  prevalence  of outbreaks of ARVI and influenza. In case of ARVI of no influenza  etiology,  the disease  develops  gradually, it is most often accompanied by cough, and begins  with usual fatigue and rhinitis  (runny nose), which makes nasal breathing difficult  and worsens  the  patient’s condition.  That is  why the  treatment  of rhinitis  is  an important  component  of the  comprehensive treatment  of ARVI and influenza.
Prospects for the Use of Methylotrophic Yeast in the Creation of Industrial Producers of Feed Enzymes
Authors: Sineoky S.P.
Published: January 2020

In recent years, mycelial fungi have faced competition from recombinant yeast producers in the production of feed enzymes. An intensive study on genetic diversity identified yeast genes encoding feed enzymes the specific activity of which is much higher than that in mycelial fungi. In addition, these genes were expressed in yeast much more efficiently than in mycelial fungi. The use of yeast recombinant producers allowed expanding the production of a line of industrial enzymes with a significant reduction in their cost. The advantages of yeast producers of recombinant enzymes include the possibility of obtain monoenzymes that are part of various enzyme complexes used for different purposes. Pichia pastoris methylotrophic yeast is the most attractive subject for the creation of recombinant protein-producing strains.

feed enzymes, Pichia pastoris, phytase, xylanase, β-glucanase, AOX1 promoter

The work was carried out using the equipment of the Multipurpose Scientific Installation of «All-Russian Collection of Industrial Microorganisms» National Bio-Resource Center, NRC «Kurchatov Institute» - GOSNIIGENETIKA

The work was funded by the Ministry of Education and Science of Russia (Project Unique Identifier RFMEFI60717X0180).
Expression of the NADP+-Dependent Formate Dehydrogenase Gene from Pseudomonas Increases the Lysine Production in Corynebacterium glutamicum
Authors: Leonova T.E. , Shustikova T.E. , Gerasimova T.V. , Ivankova Т.А. , Sidorenko K.V. Sidorenko , Yanenko A.S.
Published: January 2020

Thepsefdh_D221Q gene coding for a mutant formate dehydrogenase (PseFDG_D221Q) from Pseudomonas, which catalyzes the formate oxidation with the simultaneous formation of NADPH, has been expressed in the cells of lysine-producing Corynebacterium glutamicum strains. The psefdh_D221Q gene was introduced into С. glutamicum strains as part of an autonomous plasmid or was integrated into the chromosome with simultaneous inactivation of host formate dehydrogenase genes. It was shown that the С. glutamicum strains with NADP+ -dependent formate dehydrogenase have an increased level of L-lysine synthesis in the presence of formate, if their own formate dehydrogenase is inactivated.

L-lysine, formate dehydrogenase, NADPH, Corynebacterium glutamicum

The work was carried out using the equipment of the Multipurpose Scientific This work was carried out on the equipment of the Multipurpose Scientific Installation of «All-Russian Collection of Industrial Microorganisms», National Bio-Resource Center, NRC «Kurchatov Institute»- GosNIIgenetika.

This work was financially supported by the Ministry of Education and Science of Russia (Unique Project Identifier - RFMEFI61017X0011).
Glutamyl and Glutaminyl-tRNA Synthetases Are a Promising Target for the Design of Threonine-Producing Strain
Authors: Yuzbashev T.V. , Fedorov A.S. , Bondarenko F.V. , Savchenko A.S. , Vybornaya T.V. , Filippova S.S. , Sineoky S.P.
Published: January 2020

The present work describes an approach that improves the properties of the strain producing L-threonine via the reduction in the biomass accumulation during fermentation. Glutamyl- and glutaminyl-tRNA synthetases were chosen as targets. Mutants carrying temperature-sensitive alleles were obtained. It was shown that the used system caused the suppression of the function of tRNA synthetases which led to a rapid arrest of the culture growth, and an increase in productivity and yield of the L-threonine synthesis. One of the temperature-sensitive strains was used to obtain under non-permissive conditions of mutants with the suppressed above phenotype. Some of these mutants accumulate less biomass and produce by 10-12% more threonine than the original strain.

Escherichia coli, producing strain, threonine, aminoacyl-tRNA synthetase, ts-mutation

This work was supported by the Ministry of Science and Higher Education of the Russian Federation (project code RFMEFI61017X0011), and it was carried out using the equipment of the National Bio-Resource Center All-Russian Collection of Industrial Microorganisms, NRC «Kurchatov Institute» - GosNIIgenetika.
Laminin 521 Modulates the Сytotoxic Effect of 5-Fluorouracil on Colorectal Cancer HT29 Cells
Authors: Turchinovich A. , Tsypina I.M. , Zgoda V.G. , Nikulin S.V. , Maltseva D.V.
Published: January 2020

The cytotoxic effect of 5-fluorouracil (5FU) and regorafenib (RF)-drugs with different mechanisms of action used to treat colorectal cancer-on the HT29 cell line when cultured on plastic and laminin 521 (LM-521) has been studied. It was shown for the first time that LM-521 can increase the sensitivity of tumor cells to 5FU. Based on the analysis of the transcriptome and proteome, a possible mechanism of the observed effect of LM-521 on HT29 cell viability was proposed. The interaction of β1-containing integrins on the cell surface with LM-521 can activate the FAK/PI3K/Akt signaling pathways, promote phosphorylation of the YAP transcription coactivator and its binding to a complex with the 14-3-3σ protein. The formation of such complex leads to the YAP retention in the cytoplasm, prevents its transport to the nucleus and the activation of anti-apoptotic gene transcription.

apoptosis, β1 integrin, colorectal cancer, laminin 521 (laminin-11), regorafenib, 5-fluorouracil, HT29, ITGB1, LAMA5, YAP, SFN, 14-3-3σ

The study was funded by the Russian Science Foundation (Project 17-14-01338).
Somut ve Somut Olmayan Değerler ve Bir Yerin Miras Niteliğine Katkısı: UNESCO Dünya Miras Alan Örnekleri
Authors: Değirmenci Tansu , Köşklük Kaya Nezihat
Published: January 2020

Kültür, kültürel miras ve kültürel mirasın korunması, üzerine çokça fikir yürütülen, tanımlama yapılan ve sayısız tartışmaya konu olmuş ve olmaya devam eden başlıklardır. Tarih boyunca kültürel miras kavramına içinde bulunulan dönemin anlayışıyla çeşitli tanımlamalar getirilmiş ve kapsamı genişletilmiştir. Bugün koruma anlayışının geldiği noktada korunması gerekli unsurların kapsamı yapılardan öteye geçerek değer ve anlamlar bütününü de içine alacak şekilde genişlemiştir. Somut olmayan kültürel miras terimi ile karşılığını bulan bu miras unsuru günümüzde birçok uluslararası metin ile koruma altına alınmaya ve somut unsurlarla arasındaki ilişki çözümlenmeye çalışılmaktadır. 20. yüzyılda artan koruma bilinciyle birlikte kültürel miras kavramı ve kültürel mirası koruma yöntemleri üzerine yoğunlaşan tartışmalar uluslararası platforma taşınarak bazı örgütlerin desteklerini almıştır. UNESCO’nun da içinde bulunduğu bu örgütler finansal ve eğitimci katkılarıyla günümüz koruma yaklaşımlarını etkilemişlerdir. Bu bağlamda, UNESCO'nun 1972 Dünya Kültürel ve Doğal Mirasının Korunması Sözleşmesi ve 2003 Somut Olmayan Kültürel Mirasın Korunması Sözleşmesi adlı kültür sözleşmeleri kültürel mirasın korunması konusunda önemli kırılma noktaları olarak gözlemlenmiştir. Özellikle 1972 sözleşmesi ile hazırlanması kararı verilen Dünya Miras Listesi’ne kayıtlı miras alanlarının üstün evrensel değerinin ölçülmesine yardımcı olan kriterler korunması gerekli görülen kültürel miraslara bakış açısının anlaşılmasında önemli kaynaklardır. Bu miras alanlarında somut olmayan kültürel değerler kimi zaman bir işaretleme veya peyzajla, kimi zaman ise bir jeolojik oluşum veya yapı kompleksi gibi somut unsurlarla temsil edilmektedir. Bu bağlamda somut kültürel miras olarak mekan, özgün niteliğini zaman içinde kazanır ve anlamını atfeden miras taşıyıcıları tarafından yaşatılır, korunur ve aktarılır.
Dextran Microparticulate Inhalable Dry Powder for the Treatment of Cystic Fibrosis and Mucopolysaccharidosis
Authors: Solanki Neel R. , Patel Deepa H. , Talele Dipali R.
Published: January 2020

Background:

Cystic Fibrosis (CF) is a genetic disease which affects the patient’s lungs,
pancreas, liver, kidney and intestine and lacks sulfatase enzyme, leading to mucopolysaccharidosis.
Colistin sulfate acts by interacting with phospholipids of bacterial cell membranes. Sulfatase enzyme
reduces the high levels of sulfated glycosaminoglycans and glycolipids by the hydrolysis of sulfate
esters in lysosome.

Objective:

The aim of the present investigation was to prepare and evaluate dextran microparticulate
inhalable dry powder for the efficient targeting of colistin sulfate at affected area of lung without
causing the side effects in the treatment of CF and mucopolysaccharidosis.

Methods:

Microparticulate dry powder was prepared by the lyophilization method and evaluated for
particle size, % yield, % drug content, solid state characterization, in-vitro lung deposition study, and
in-vitro drug release study.

Results:

Particle size, % yield and % drug content were found to be 4.03 ± 0.196 µm, 94.02 % and
99.45 ± 0.015% respectively. Bulk density, tapped density, hausner’s ratio, carr’s index and angle of
repose of optimized batch were found to be 0.216 ± 0.025 g/cm3, 0.236 ± 0.035 g/cm3, 1.09 ± 0.026,
8.47 ± 0.025 % and 26.10 ± 0.029˚ respectively. A fine particle fraction, fine particle dose, mass median
aerodynamic diameter, geometric standard deviation and emitted dose were found to be 66.78%, 16.45
mg, 4.89 µm, 1.32 and 246.33 mg respectively. The % CDR of optimized batch was found to be 96.12 ±
0.049 % at 24 h.

Conclusion:

Based on the obtained results, we conclude that dextran microparticulate inhalable dry
powder might be suitable carrier for the delivery of colistin sulfate and sulfatase in combination via
pulmonary route for the treatment of cystic fibrosis and mucopolysaccharidosis.
The Prevalence of Vitamin D Deficiency in Iran: A Literature Review
Authors: Bagherniya Mohammad , Khorasanchi Zahra , Bidokhti Mina S. , Ferns Gordon A. , Rezaei Mitra , Ghayour-Mobarhan Majid , Sahebkar Amirhossein
Published: January 2020

Background:

Vitamin D deficiency is a common medical condition worldwide. In Iran, it
has been reported that between 30-90% of people have vitamin D deficiency. However, its distribution
in different parts of the country and among different age and regional groups is unclear. Therefore,
the aim of this study was to review the recent literature on vitamin D deficiency in Iran.

Methods:

The literature review was performed using Web of Science, PubMed-Medline, Scopus and
Scientific Information Database (SID) with a cut-off date of November 2016 to identify articles on
vitamin D status in Iran published in the last 10 years. Studies in English and Persian that reported
vitamin D levels in male and female subjects of all age groups and in healthy populations were included.

Results:

From 325 studies that were initially retrieved, 82 articles met the inclusion criteria. A high
prevalence of vitamin D deficiency was reported, and in some regions, this was reported as >90%
and was found in all age groups and in all regions of Iran.

Conclusion:

This review highlights the very high prevalence of vitamin D deficiency in Iran. It will
be important to recognize the importance of vitamin D deficiency as a major public health problem in
Iran.
Antiangiogenesis Potential of Alpinumisoflavone as an Inhibitor of Matrix Metalloproteinase-9 (MMP-9) and Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2)
Authors: Alos Honeymae C. , Billones Junie B. , Vasquez Ross D. , Castillo Agnes L.
Published: January 2020

Background:

Cancer is a very serious public health problem ranking as the second leading
cause of death worldwide. Angiogenesis plays a vital role as a prerequisite for tumor growth and
metastasis, and is indispensable in the further stage advancement of cancer.

Objective:

Targeting several enzymes and receptors in angiogenesis’ signal transduction pathway
will likely offer many more prospects for successful and superior therapeutic intervention.

Method:

Thus, druggable targets in the angiogenesis pathway such as pro-MMP9, MMP-9, EGFR,
VEGF-A, VEGFR-1, VEGFR-2, c-MET kinase, KIT kinase, CSF1R, TIE-2, and RET tyrosine
kinase were the subject of this molecular docking study involving Alpinumisoflavone (AIF), a
multi-targeted natural product with known anticancer activities.

Results:

The results showed that AIF exhibited good binding affinity with all the selected key
angiogenesis promoting proteins with greatest in silico activity in MMP-9 and VEGFR-2. Moreover,
in silico ADMET studies showed that AIF has good intestinal absorption property and solubility, and
very low probability of being carcinogenic, mutagenic, and toxic to embryo or fetus.

Conclusion:

Molecular docking study revealed that Alpinumisoflavone (AIF) could serve as a
promising lead in the development of angiogenesis (multikinase) inhibitor based on its predicted
binding affinity with vital angiogenesis targets.
Design and Analysis of X-OR Gate and 4-Bit Binary to 4-Bit Gray and Gray to Binary Code Converter Using Dual Control Dual SOA TOAD (DCDS-TOAD)
Authors: Maji Kajal , Mukherjee Kousik
Published: January 2020

Background:

In this paper we have design and analyzed 4-bit binary to 4-bit gray code and
4-bit gray to 4-bit gray code converter using dual control dual semiconductor optical amplifier terahertz
optical asymmetric demultiplexer (DCDS-TOAD). We used control pulse as a Soliton pulse
train. We calculate the extinction ratio, contrast ratio and Q value and found very high values. The
high values of E.R., C.R. and Q value distinguishes the high (‘1’) level to the low(‘0’) very clearly also
shown the variation of E.R., C.R. and Q value with control pulse energy and amplified spontaneous
emission power factor.

Methods:

The basic equations governing the TOAD performance is simulated using MATLAB. The
extinction ratio, contrast ratio and Q value are calculated for analysis of the device.

Results:

Results of operation for the code converters are performed at a bit rate of 100Gbps. The
structure of DCDSTOAD enable us to achieve high values of ER(~ 81dB), CR(~83dB) and Q factor
(86dB). A high Q factor shows very low bit error rate (BER). The eye diagram shows a large eye
opening (REOP~98.5%).

Conclusion:

Design and analyzed 4-bit binary to 4-bit gray code and 4-bit gray to 4-bit gray code
converter using dual control dual semiconductor optical amplifier terahertz optical asymmetric demultiplexer
(DCDS-TOAD) is proposed and analyzed. We used control pulse as a Soliton pulse train. The
proposed X-OR gate finds applications in many devices.
Improvement of Gain Accuracy and CMRR of Low Power Instrumentation Amplifier Using High Gain Operational Amplifiers
Authors: Sahu Rashmi , Konar Maitraiyee , Kundu Sudip
Published: January 2020

Background:

Sensing of biomedical signals is crucial for monitoring of various health conditions.
These signals have a very low amplitude (in μV) and a small frequency range (<500 Hz). In
the presence of various common-mode interferences, biomedical signals are difficult to detect. Instrumentation
amplifiers (INAs) are usually preferred to detect these signals due to their high commonmode
rejection ratio (CMRR). Gain accuracy and CMRR are two important parameters associated
with any INA. This article, therefore, focuses on the improvement of the gain accuracy and CMRR of
a low power INA topology.

Objective:

The objective of this article is to achieve high gain accuracy and CMRR of low power INA
by having high gain operational amplifiers (Op-Amps), which are the building blocks of the INAs.

Methods:

For the implementation of the Op-Amps and the INAs, the Cadence Virtuoso tool was used.
All the designs and implementation were realized in 0.18 μm CMOS technology.

Results:

Three different Op-Amp topologies namely single-stage differential Op-Amp, folded cascode
Op-Amp, and multi-stage Op-Amp were implemented. Using these Op-Amp topologies separately,
three Op-Amp-based INAs were realized and compared. The INA designed using the high gain multistage
Op-Amp topology of low-frequency gain of 123.89 dB achieves a CMRR of 164.1 dB, with the
INA’s gain accuracy as good as 99%, which is the best when compared to the other two INAs realized
using the other two Op-Amp topologies implemented.

Conclusion:

Using very high gain Op-Amps as the building blocks of the INA improves the gain accuracy
of the INA and enhances the CMRR of the INA. The three Op-Amp-based INA designed with
the multi-stage Op-Amps shows state-of-the-art characteristics as its gain accuracy is 99% and CMRR
is as high as 164.1 dB. The power consumed by this INA is 29.25 μW by operating on a power supply
of ±0.9V. This makes this INA highly suitable for low power measurement applications.
Circular Slotted Antenna with CPW feed for GSM and UWB Applications
Authors: Kumar Sanjeev , Kumar Ravi , Nandan Durgesh
Published: January 2020

Background & Objective:

The circular slotted monopole microstrip antenna with Coplanar
Waveguide (CPW) feed for unified GSM and Ultra-Wideband (UWB) applications have been
presented in this article. Circular shaped slots have been embedded in the radiating patch. Less surface
area has been found due to slots etching and the overall antenna size is reduced by 45%.

Result:

The proposed antenna demonstrates a double band operation wrapping 883.6-1206 MHz
(GSM band) and 2.75-18.30 GHz (UWB, X, and Ku) frequency band with VSWR of less than 2 and
fractional B. W. of 30.8 % and 147% respectively. The pattern of radiation presented by the antenna
is nearly omnidirectional in H-plane and directional in E-plane within the GSM and UWB band.

Conclusion:

There is a variety of applications nowadays using these UWB antennas such as modern
civil and military applications, wireless and radar communications, etc. Measured results are
presented to validate the proposed antenna structure, which shows that the proposed designed antenna
structure has a stable radiation pattern both at the GSM and UWB band ranges.
Green Three-component Synthesis of Merocyanin Dyes Based on 4- Arylideneisoxazol-5(4H)-ones
Authors: Damghani Fatemeh K. , Kiyani Hamzeh , Pourmousavi Seied A.
Published: January 2020

A one-pot three-component reaction promoted by choline chloride: zinc(II) chloride deepeutectic
solvent (ChCl-ZnCl2 DES) in an aqueous medium for the synthesis of several merocyanin
dyes based on isoxazol-5(4H)-ones is presented. This three-component approach is efficient, clean,
experimentally simple, convenient, safe, and environmentally friendly. This reaction was performed at
room temperature without using energy sources such as heat, microwave and ultrasound waves. Nonuse
of toxic solvents, available materials, one-vessel, no wasted reagents, simple preparation, and recyclability
of DES are other important points of this method that is significant from the perspective of
green chemistry.
Dynamic Feature Extraction Method of Phone Speakers Based on Deep Learning
Authors: Zhang Hongbing
Published: January 2020

:

Nowadays, speech recognition has become one of the important technologies for human-
computer interaction. Speech recognition is essentially a process of speech training and pattern
recognition, which makes feature extraction technology particularly essential. The quality of
feature extraction is directly related to the accuracy of speech recognition. Dynamic feature parameters
can effectively improve the accuracy of speech recognition. These parameters make the
speech dynamic feature extraction to have a higher research value. The traditional dynamic feature
extraction method is easier to generate more redundant information, resulting in low recognition
accuracy. Therefore, based on a new speech feature extraction method, which is based on deep
learning for speech feature extraction, is proposed in the present study. Firstly, the speech signal is
preprocessed by pre-emphasis, windowing, filtering, and endpoint detection. Then, the sliding differential
cepstral feature (SDC) is extracted, which contains the voice information of the front and
back frames. Finally, the feature is used as input to extract the dynamic features that represent the
depth essence of speech information through the deep self-encoding neural network. The simulation
results show that the dynamic features extracted by in-depth learning have better recognition
performance than the original features, and have a good effect on speech recognition.
Phonotactics, prophylaxis, acquisitionism and change: *Rime-xxŋ and ash-tensing in the history of English
Authors: Honeybone Patrick
Published: January 2020

This article revisits, extends and interrogates the position advocated in Honeybone (2019) — that phonotactic constraints are psychologically real phonological entities (namely: constraints on output-like forms), which have a diachrony of their own, and which can also interfere with diachronic segmental change by inhibiting otherwise regular innovations. I focus in the latter part of the article on the role of one phonotactic constraint in the history of English: *Rime-xxŋ. I argue that we need to investigate the emergence of such constraints in the history of languages and I show how this particular constraint, once innovated (which occurs through constraint scattering), can be understood to have inhibited the patterning of ash-tensing in certain varieties of American English (and also that it may now have been lost in some varieties). To do this, I adopt a phonological model which combines aspects of Rule-Based Phonology and aspects of Constraint-Based Phonology, and which is firmly rooted in the variation that exists when changes are innovated. Finally, I evaluate the extent to which the type of phonotactically-driven process-inhibition that I propose here involves prophylaxis in phonological change (I show that it doesn't), and I consider the interaction of these ideas with the proposal that all change occurs in language acquisition (‘acquisitionism’).
Las disputas entre el campo religioso católico y el Estado. Breve reseña sobre el libro: Monjas y prostitutas: Redes, estrategias y capital simbólico de Damián Truccone.
Authors: Chew Plascencia Serena
Published: January 2020

Reseña
La prostitución en el corazón del capitalismo de Rosa Cobo
Authors: Hernández Velasco Tania
Published: January 2020

Reseña
La revisión del régimen jurídico de la privacidad en la Unión Europea
Authors: Ballesteros Moffa Luis Ángel
Published: January 2020

Es conocido el momento de madurez que atraviesa el instituto de protección de datos personales en la Unión Europea, con una ambiciosa renovación de su régimen común, que obligará a revisar la regulación interna de los Estados miembros. La Directiva 95/46/ CE, del Parlamento Europeo y del Consejo, de 24 de octubre de 1995, relativa a la protección de las personas físicas en lo que respecta al tratamiento de datos personales y a la libre circulación de estos datos, tiene los días contados merced a la aprobación del Reglamento (UE) 2016/679, del Parlamento Europeo y del Consejo, de 27 de abril de 2016. El cual obedece a los nuevos retos tecnológicos y de globalización, unidos a la necesidad de una regulación homogénea directamente aplicable que evite las divergencias en la ejecución y aplicación de la Directiva, aunque no será aplicable hasta el 25 de mayo de 2018. Renovación que, también en forma de Reglamento europeo de directa aplicación, se hace extensiva a los particulares riesgos que las comunicaciones electrónicas, y, sobre todo, Internet, representan para la información personal. A la vez que se hace más exigente desde esta perspectiva la lucha común contra la delincuencia organizada y el terrorismo, según evidencian la Directiva (UE) 2016/680 de policía y la Directiva (UE) 2016/681 de transferencia de datos PNR.
La subsunción de Alexy y la pregunta por la racionalidad de la ponderación
Authors: Garzón Cárdenas Ricardo
Published: January 2020

Este trabajo analiza al detalle la argumentación de Robert Alexy en virtud de la cual la subsunción resulta poco racional, por cuanto existe un método que lo es más, como es la ponderación. La hipótesis de trabajo es que una descripción imprecisa de la subsunción permite ambientar el debate sobre la racionalidad de la ponderación y, a la postre, declarar resuelto a su favor dicho debate. Esta descripción incorrecta, más el entendimiento erróneo de las nociones de justificación interna y justificación externa de Jerzy Wróblewski y poner desatinadamente a Jürgen Habermas como “crítico de la fórmula de la ponderación”, permitirá generar la impresión de la resolución del problema de la racionalidad de este método de aplicación de principios.
La fenomenología y la argumentación jurídica: ¿una conexión posible?
Authors: Pinto Alberto Tiago Gagliano
Published: January 2020

Este artículo tiene como reto desarrollar una comprensión de la argumentación jurídica desde la óptica de la teoría fenomenológica creada por Edmund Husserl en el seno filosófico, y más adelante desarrollada por otros autores ya en el ambiente del derecho. Lo que se presenta es una propuesta que, si bien sucedida y aplicada, podrá añadirle a los fallos elementos imprescindibles de la fenomenología haciendo que la argumentación desarrollada por las Cortes de Justicia se vuelva más racional. Como marcos teóricos, el artículo invoca principalmente las enseñanzas de Edmund Husserl, Adolf Reinach y Gerhart Husserl, además de otros autores directa o indirectamente referidos. De la misma forma, algunos fallos y teorías utilizados por la Corte Interamericana de Derechos Humanos – CIDH y el Tribunal Constitucional alemán se utilizan como prueba para la finalidad propuesta por el artículo. Por fin, en el artículo se utiliza la metodología deductiva, siendo descriptivo en cuanto a la fenomenología y propositivo al sugerir la utilización de este aporte filosófico en la argumentación jurídica.
Ubi societas, ibi ius? Sobre el lugar del derecho en las teorías clásicas del patrón cultural universal
Authors: Rivaya García Benjamín
Published: January 2020

No es infrecuente entre los antropólogos entender el Derecho como universal cultural. Que algún rasgo humano sea universal se puede explicar porque es natural, pero el Derecho no es natural. La pregunta entonces es si existen rasgos culturales, no naturales, universales, a lo que los antropólogos suelen responder afirmativamente. La otra pregunta sería la de si el Derecho es un universal cultural, lo que en buena medida depende del concepto de Derecho que utilicemos. No son pocos los antropólogos que, utilizando una  perspectiva amplia sobre el Derecho, piensan que sí es un rasgo universal.
Clientelismo político en Cuetzalan, Puebla
Authors: Lozano O´   Reilly María Teresa
Published: January 2020

Debido a su alto grado de marginalidad, el municipio de Cuetzalan constituye un espacio propicio para que se presente el llamado clientelismo político. Adicionalmente, el ingreso del sistema de partidos a los espacios tradicionalmente comunitarios ha desvirtuado la idea de que merece gobernar aquella persona que ha trabajado en favor de la comunidad y constituye un ejemplo a seguir. Actualmente detentan el poder quienes han tenido acceso a recursos para repartir. Esta situación genera un compromiso moral para retribuir los beneficios recibidos, aunado al temor de perderlos. Se ha naturalizado la idea de que un buen candidato o candidata es quien tiene recursos para repartir y por lo tanto, merece gobernar. Dichas conductas constituyen violaciones a los derechos humanos por lo que es importante denunciarlas y de esta manera mandar un mensaje a la sociedad de que están prohibidas y deben ser reprobadas.
Estudio sobre la legalidad en la determinación del precio y el impuesto a los combustibles
Authors: Contreras Borbón Omar
Published: January 2020

Este artículo ofrece un panorama del proceso de modificación contemporánea de las normas establecidas en la Ley del Impuesto Especial sobre Producción y Servicios que han avalado tres impuestos IEPS distintos al combustible y dos impuestos al valor agregado; además realiza una aproximación al cálculo de los componentes del precio del combustible tras la liberación de precios de 2017. El autor afirma de ilegal e inconstitucional la manera en que las autoridades administrativas determinan los precios e impuestos de los combustibles, por considerarlo violatorio del principio de doble imposición, contrario al principio de certeza tributaria, al de proporcionalidad, al de legalidad y constitucionalidad. El estudio concluye con una propuesta de solución sencilla que pareciera ser una medida correctiva rápida a la situación y problema fiscal que padecemos en el país, principalmente en la región fronteriza, sobre todo por competir en precio con el sur de Estados Unidos.
Hacia la universalización de la seguridad social en México: análisis jurídico de la problemática que genera la duplicidad en el aseguramiento
Authors: González Posadas Jessica Guadalupe
Published: January 2020

En nuestro país, la seguridad social es concebida como un derecho obrero, garantizado por el artículo 123 de la Constitución Política de los Estados Unidos Mexicanos, en la fracción XXIX del apartado A y las fracciones XI y XIII del apartado B; situación que per sé genera una delimitación de su cobertura –así como de su financiamiento-, constriñéndose a la población económicamente activa. En consecuencia, el sistema de seguridad social mexicano se ha manifestado, desde su concepción, como un régimen limitado –debido a la falta de universalidad en su cobertura- y fragmentado –ante la multiplicidad de instituciones primariamente responsables de la prestación de los servicios públicos correspondientes- que, a últimas fechas, puede calificarse además como desfinanciado, por la escases de reservas suficientes para garantizar su sustentabilidad. Tales vicios primigenios han propiciado una duplicidad en el aseguramiento -entendida ésta como la doble o hasta triple cobertura de un mismo individuo respecto de las diversas instituciones que prestan estos servicios de solidaridad social-, así como una inadecuada interpretación y aplicación de las legislaciones existentes en materia de seguridad social por los operadores jurídicos; causando un detrimento directo de las finanzas que soportan nuestro tambaleante sistema de seguridad social.
PENERAPAN STRATEGI GENIUS LEARNING DENGAN OPERAN KERTAS IDE
Authors: Iltavia Iltavia , Yuliani Pristy
Published: January 2020

The purpose of this study was to determine the results of cognitive, affective, and psychomotor learning of students with the application of Genius Learning Strategy with Idea Paper Operations. The type of research is experimental research. The research design that will be used is Randomized Control Group Design. Where for the experimental class is the class that feels with the Genius Learning strategy with Operan Kertas Ide Technique, while the control class is a powerless class with the Genius Learning strategy with Operan Kertas Ide Technique. The results of research on cognitive learning outcomes that implemented the Genius Learning strategy with Operan Kertas Ide is better than the result of learning mathematics students without implementing Genius Learning strategy with Operan Kertas Ide on the material set in class VII SMP Padangpanjang. The learning outcomes of students in the affective and psychomotor domains obtained through the observation sheet increased in each meeting during the learning process that implemented the strategy of Genius Learning with Idea Paper Operations in the class VII SMP Padangpanjang. So, it can be concluded that Genius Learning Strategy with Idea Paper Idea can improve students' cognitive, affective and psychomotor learning outcomes.
Prevalence of imaginary companions among Chinese children aged 4 to 6 years
Authors: Lin Qiyi , Zhou Nan , Fu Hong
Published: January 2020

We investigated the prevalence of Chinese children's imaginary companions (ICs) and the internal variables of IC types (personified object or invisible friend) and child–IC relationship qualities (egalitarian or hierarchical child–IC relationship). Participants were 266
children aged 4 to 6 years. Only in the 5-year-old group was the proportion of children with ICs significantly higher among girls than among boys, implying that the relationship between gender and IC was not consistent across age groups. Children from families in the highest annual income
group engaged in more IC play than did children from families in the lowest annual income group, indicating a relationship between family socioeconomic environment and children's imaginary play. IC types were not associated with child–IC relationship qualities in any of the age groups,
implying that these qualities may represent different dimensions of IC play as early as 4 years old.
“Si el cielo existe, se llama Perú”
Authors: Oliveira Luiz Sérgio De
Published: January 2020

Resenha da exposição Crónicas Migrantes. Historias comunes entre Perú y Venezuela, realizada pelo / no Museo de Arte Contemporáneo de Lima, Peru, de 12 de setembro de 2019 a 2 de fevereiro de 2020, com curadoria de Fabiola Arroyo. A mostra reuniu obras de mais de 30 artistas peruanos e venezuelanos.
Estado fiscal, tributação e os critérios de justiça no direito tributário
Authors: Difini Luiz Felipe Silveira , Jobim Eduardo De Sampaio Leite
Published: January 2020

RESUMOO presente artigo visa analisar a tributação no Estado Fiscal sob os critérios de justiça tributária. A análise tradicional da justiça tributária exige que a distribuição do ônus fiscal satisfaça o' critério de igualdade vertical e horizontal, sendo exigência da igualdade – enquanto critério de justiça - que a lei trate de forma igual os iguais e os desiguais de forma diferente de acordo com as suas possibilidades de fazer frente ao ônus fiscal. Vários critérios foram propostos nesse sentido, desde a teoria do benefício até a tributação em perspectiva da capacidade contributiva. Este artigo visa evidenciar como o direito tributário pode ser fundamentado levar em conta os fins de justiça, focando especialmente no princípio da capacidade contributiva e os seus subprincípios.PALAVRAS-CHAVEDireito tributário. Justiça tributária. Princípio do benefício. Capacidade contributiva. ABSTRACTThe present article focuses on the analysis of taxation in the Fiscal State regarding the concepts of tax justice. Traditional analysis of tax justice requires that the distribution of tax burdens meets the criterion of vertical and horizontal equity, and it is a requirement of equity - as a criterion of justice - that like cases should be treated alike and relevantly different cases should be treated differently according to their possibilities to cope with the tax burden. Various criteria for relevant differences have been proposed, drawing on ideas such as ability to pay and taxation in proportion to benefit. This article aims to show how tax law may be founded taking into account goals of justice, focusing especially on the principle of Contributive Capacity and its subprinciples.KEYWORDSTax law. Tax justice. Benefit principle. Contributive Capacity.
El señalamiento del orden de los apellidos de la persona, en el Anteproyecto de Reforma del Código Civil Peruano. Primeras impresiones
Authors: Álvarez César Carranza
Published: January 2020

RESUMENEn el siguiente texto, el autor analiza el nombre de la persona, con especial atención en la regulación propuesta por el Anteproyecto de Reforma del Código Civil respecto al orden de sus apellidos; valiéndose para ello de las normas vigentes del Código sustantivo, las experiencias del Derecho comparado y los proyectos legislativos del Congreso de la República del Perú sobre el particular.PALABRAS CLAVEDerecho civil. Nombre de la persona. Apellidos de la persona. Anteproyecto de Reforma del Código Civil peruano. Elementos de la personalidad. ABSTRACTIn the following text, the autor analyzes the name of the person, with a focus on the regulation proposed by the Civil Code Reform Project regarding the order of their surnames, relying on existing rules of substantive Code; the experiences of comparative law and legislative projects of the Congress of the Republic of Perú on the subject.KEYWORDSCivil law. Name of the person. Surname of the person. Peruvian Civil Code Reform Project. Elements of personality.
Lei e Estado Social: da legislação operária aos dilemas do welfare “sem lei”.
Authors: Cazzetta Giovanni
Published: January 2020

RESUMODiante do atual debate no cenário europeu acerca da possibilidade de manutenção dos direitos sociais em meio à desregulação estatal, este artigo aborda a construção desses direitos no fim do século XIX e início do século XX, inicialmente garantidos por instituições parcialmente estatais. Por meio da análise de coleções legislativas comentadas, o autor apresenta perspectivas da época acerca do assentamento da legislação social dentro do direito civil italiano, além da posterior expansão da legislação social pela Europa.PALAVRAS-CHAVEHistória do direito. Direitos sociais. Legislação social. Intervenção estatal. ABSTRACTIn faced of the current European debate on the possibility of maintaining social rights in the midst of state deregulation, this article addresses the construction of such rights in the end of the 19th and the beginning of the 20th century. Those rights were initially guaranteed by partially public institutions. Through the analysis of commented legislative collections, the author presents perspectives of that time concerning the settlement of social legislation within Italian civil law, besides the subsequent expansion of social legislation throughout Europe.KEYWORDSLegal history. Social rights. Social legislation. State intervention.
TRANSFORMAÇÕES POLÍTICAS NA PRODUÇÃO DE SENSIBILIDADE NA DANÇA DO VENTRE
Authors: Silva Ângela Vieira da , Silva Fabio Hebert da , Yonezawa Fernando Hiromi
Published: January 2020

Este artigo trata da produção de sensibilidades no processo de gestar um corpo dançante na dança do ventre e das transformações políticas daí decorrentes. Este trabalho origina-se de dissertação de mestrado em Psicologia Institucional. O campo de investigação desta pesquisa-intervenção foi um projeto de extensão universitário oferecido a sete mulheres que desconheciam essa modalidade de dança. O recurso do registro das aulas em vídeo constituiu a metodologia, que incluiu ainda uma análise qualitativa deste material, norteada pela concepção deuleuzo-guattariana de arte e pela visão crítica acerca do Orientalismo. Um dos principais resultados obtidos foi a desconstrução da política dominante de sentir e mover-se, gerada pelas sensibilidades e gestualidades suscitadas no processo de aprender a dançar. Depoimentos das participantes presentes nos registros permitem concluir que o processo de gestar um corpo dançante porta uma potência de desestabilização das percepções e sentimentos culturalmente assentados.
CULTURA PHYSICA E VIDA AO AR LIVRE: A REINVENÇÃO DO LITORAL DE FORTALEZA (1920-1940)
Authors: Montenegro Nara Romero , Soares Carmen Lúcia
Published: January 2020

Importantes e inéditas transformações se operam no imenso litoral brasileiro nas primeiras décadas do século XX. Nosso estudo examina essas transformações tomando como delimitação geográfica o litoral de Fortaleza, as inúmeras atividades de divertimento e outras voltadas à educação e à saúde que ali se desenvolveram. Já nas décadas de 1920 e 1930 também surge ali nova arquitetura que recorta esse litoral com bangalôs, casas, comércios, clubes esportivos e recreativos. Discursos e práticas higienistas associados a um ideário de vida ao ar livre exortam a população não só a admirar o litoral, mas a usufruir de seus benefícios. O presente artigo objetiva analisar a relação entre a reinvenção do ambiente litorâneo de Fortaleza e os discursos, cada vez mais frequentes, em torno de uma cultura physica. Em termos metodológicos, realizamos uma pesquisa documental que teve como fontes: jornais, revistas, textos literários, relatos de memorialistas e imagens do período.