bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Synthesis of Bronchospasmolytic Agent Flutropium Bromide and Some Homologues and Configuration Isomeric Compounds.
Authors: BANHOLZER R. , POOK K.‐H. , STIASNI M.
Published: May 2016

Die Veresterung von Benzilsäure mit Tropin (Ib) bzw. dem Nortropin‐ Derivat (III) gelingt mit dem Benzilsäureimidazolid (IV).
ChemInform Abstract: The Reaction of 2,2‐Dimethyl‐4‐lithio‐1,3‐oxathiane 3,3‐Dioxide.
Authors: FUJI K. , NODE M. , USAMI Y.
Published: May 2016

2,2‐Dimethyl‐1,3‐oxathiane (I) is oxidized to the sulfone (II), which is lithiated to (III) and subsequently treated with electrophilic reagents, such as the alkylating agents (IV) and the carbonyl derivatives (VI), to yield the substituted sulfones (V) and (VII).
ChemInform Abstract: 4‐(Benzyloxy)morpholine‐2,3,5‐triones and 3‐(Benzyloxy)oxazolidine‐2,4‐ diones from N‐(Benzyloxy)glycolamides and Oxalyl Chloride.
Authors: GEFFKEN D. , STROHAUER K.
Published: May 2016

Die Umsetzung der N‐ Benzyloxy‐2‐hydroxycarbonamide (I) mit Oxalylchlorid führt bei den an C‐2 disubstituierten Verbindungen (Ia)‐(Id) zu einem Gemisch aus Morpholintrionen (II) und den Oxazolidindionen (III), das chromatographisch getrennt werden kann.
ChemInform Abstract: Ring‐Expansion by a Wittig‐Prévost Sequence.
Authors: EL‐HOSSINI M. S. , MCCULLOUGH K. J. , MCKAY R. , PROCTOR G. R.
Published: May 2016

The tetralones (I) are converted to the methylene derivatives (II), which then react with silver nitrate, iodine, and methanol to produce the ring expansion products (III); (IV) and (V) are obtained as by‐products.
ChemInform Abstract: Synthesis of Optically Active Diamino‐diimine Macrocycle(6S,15S)‐1,5,10,14‐tetraaza‐4,13‐dimethyl‐tricyclo[13.3.1.16,10]icosa‐4,13‐diene and Molecular structure of Its Nickel(II) Complex.
Authors: MIYAMURA K. , SABURI M. , GOHSHI Y. , TSUBOYAMA S. , SAKURAI T.
Published: May 2016

The chiral amines (I) react with 3‐buten‐2‐one (II) to produce the optically active macrocycles (III); the monocyclic tetraaza compound (V) is obtained from ethylene diamine (IV) and (II).
ChemInform Abstract: Chemistry of 1,8‐Substituted Naphthalenes. Part 16. Synthesis and Hydrolysis of 2‐Dimethylaminonaphth[1,8‐bc]oxepinium Salts.
Authors: MEZHERITSKII V. V. , TKACHENKO V. V. , PIKUS A. L.
Published: May 2016

The condensation of the naphthaldehydes (I) with the adduct from POCl3 and AcNMeg or of the dimethylamides (III) with the adduct from POCl3 and DMF affords the title compounds (II).
ChemInform Abstract: Stereo‐ and Regiospecific Syntheses to Provide Conjugated (E,Z)‐ and (Z,Z)‐Alkadienes, and Arylated (Z)‐Alkenes in Excellent Yields via the Palladium‐Catalyzed Cross‐Coupling Reactions of (Z)‐1‐Alkenylboronates with 1‐Bromoalkenes and Aryl Iodides.
Authors: MIYAURA N. , SATOH M. , SUZUKI A.
Published: May 2016

The bromoacetylenes (I) are coupled with the boranes (II) to give the olefins (III), which rearrange to the olefins (IV) when treated with tert‐butyllithium.
ChemInform Abstract: Large‐Scale Synthesis of Pinacol Iodomethaneboronate and Its Application to (Acylamino)methaneboronates via (Trimethylsilyl)lithioamines.
Authors: PHILLION D. P. , NEUBAUER R. , ANDREW S. S.
Published: May 2016

Aus Dimethylsulfid (I) erhält man über (III) das Iodmethanboronat (IV), das zur Substitution der aus (V) erhaltenen Silylaminoverbindung (VI) zu (VII) herangezogen werden kann.
ChemInform Abstract: (S,S)‐Diisopropylethanediol ("DIPED"): A New Chiral Director for the α‐Chloro Boronic Ester Synthesis.
Authors: MATTESON D. S. , KANDIL A. A.
Published: May 2016

The chiral boronic ester (I) reacts with dichloromethyl lithium (II) giving (III) which is converted to the ether (IV).
ChemInform Abstract: Matrix Isolation of a Silicon‐Nitrogen Double Bonded Silaimine.
Authors: SEKIGUCHI A. , ANDO W. , HONDA K.
Published: May 2016

Photolysis of the dimesityl trimethylsilyl azide (I) in cyclohexane and the alcohols (IV) produces the disilazanes (V) via the nitrene (II) and the silaimine (III).
ChemInform Abstract: Observation of a Silanimine in an Inert Matrix and in Solution at Low Temperature.
Authors: ZIGLER S. S. , WEST R. , MICHL J.
Published: May 2016

Trimesityl silylazide (I) is irradiated at a low temperature (77 K) yielding the silanimine (II) and the silaisoindole (III).
ChemInform Abstract: Cycloaddition of Stable Disilenes to Terminal Acetylenes.
Authors: DE YOUNG D. J. , WEST R.
Published: May 2016

Reaction of the disilene (I) with thg acetylenes (II) produces the airstable disilacyclobutenes (III).
ChemInform Abstract: Phosphorus‐Phosphorus Single or Double Bond Formation from PCl3‐nRn (n = 1 or 2) and a Bis‐imidazolidine Reducing Agent.
Authors: GOLDWHITE H. , KAMINSKI J. , MILLHAUSER G. , ORTIZ J. , VARGAS M. , VERTAL L. , LAPPERT M. F. , SMITH S. J.
Published: May 2016

The phosphinous chlorides (II) are transformed into the diphosphines (III) by a mild reduction method using bis‐imidazolidine (I).
ChemInform Abstract: A Neutral Water‐Soluble Aluminum Complex of Neurological Interest.
Authors: FINNEGAN M. M. , RETTIG S. J. , ORVIG C.
Published: May 2016

The 1:3 molar reaction of Al(NO3)3‐9 H2O with maltol in aqueous solution leads to the A1 complex (I) in good yield which is remarkably stable in pH range of 4‐9. This complex is characterized by spectroscopic studies (′H NMR, IR, MS) and X‐ray structural analysis (space group Pbca, Z=8) which confirms mer‐arrangement of the three ligands.
ChemInform Abstract: Mixed Carbonyl‐Isocyanide and Carbonyl‐Nitrile Complexes Derived from the Reactions of the Multiply Bonded Dirhenium(II) Complexes Re2X4(dppm)2(CO) (X: Cl or Br; dppm: Ph2PCH2PPh2). The Structural Characterization of Cl2Re(μ‐Cl)(μ‐dppm)2ReCl(CO) and Cl2Re(μ‐Cl)(μ‐CO)(μ‐dppm)2ReCl(CNxylyl).
Authors: COTTON F. A. , DUNBAR K. R. , PRICE A. C. , SCHWOTZER W. , WALTON R. A.
Published: May 2016

Reaction of the triply bonded dirhenium Complexes (I) with CO yields the monocarbonyls (II).
ChemInform Abstract: A Binuclear Iron Peroxide Complex Capable of Olefin Epoxidation.
Authors: MURCH B. P. , BRADLEY F. C. , QUE L. JUN.
Published: May 2016

The triply bridged binuclear Fe(II I) complex (Ia) is prepared by addition of acetate at pH 5 to its hydroxodiaquo analogues and metathesis with NMe4Cl (no yield given).
ChemInform Abstract: Synthesis of Polynitroalkyl Ferrocenes.
Authors: TVERDOKHLEBOV V. P. , POLYAKOVA N. YU. , TSELINSKII I. V.
Published: May 2016

The title Compounds (I I I) are obtained either by reaction between the ferrocenylcarbinols (I) and the polynitroalkanes (I I) or by reacting the ferrocenylalkyl tetrafluoroborates (VII) with the potassium salts (VIII).
ChemInform Abstract: Haptotropic Rearrangement of Tricarbonyl(2‐acyloxytropone)iron.
Authors: MORITA N. , ASAO T. , TAJIRI A. , SOTOKAWA H. , HATANO M.
Published: May 2016

The photolytic reaction of the 2‐hydroxy‐tropone derivatives (I) with iron pentacarbonyl (II) produces the haptotropic isomers (III) and (IV).
ChemInform Abstract: [2 + 2]Cycloaddition Reactions of Cationic Iron Vinylidene Complexes.
Authors: BARRETT A. G. M. , STURGESS M. A.
Published: May 2016

The cationic iron Vinylidene complexes (II) are prepared from carbonyl complexes (I).
ChemInform Abstract: Unusually Detailed Insight into the Dynamic Behavior of Coordinated Ambidentate Ligands.
Authors: MARZILLI L. G. , SUMMERS M. F. , ZANGRANDO E. , BRESCIANI‐PAHOR N. , RANDACCIO L.
Published: May 2016

Endocyclic N‐bound 2‐aminopyridine when coordinated to B12 coenzyme models simulates the very long Co‐ N bonds characteristic of axially bound 5,6‐dimethylbenzimidazole in cobalamins.
ChemInform Abstract: Model for the Initial Stage in the Oxidative Addition of I2 to Organoplatinum (II) Compounds.
Authors: VAN BEEK J. A. M. , VAN KOTEN G. , SMEETS W. J. J. , SPEK A. L.
Published: May 2016

The 1:1 molar reaction of the iodo‐Pt(II) complex (I) with I2 leads to the stable title complex (II) which is characterized by X‐ray structural analysis (space group P2,2,2" Z=4), UV, and 1H NMR spectral data.
ChemInform Abstract: Asymmetric Synthesis of α‐Amino Acids by Alkylation of a Glycine Amide Derivative Bearing Chiral 2,5‐Disubstituted Pyrrolidine as an Amine Component.
Authors: IKEGAMI S. , HAYAMA T. , KATSUKI T. , YAMAGUCHI M.
Published: May 2016

The optically active amide (I) is alkylated and subsequently hydrolyzed to yield the substituted glycine derivatives (IV).
ChemInform Abstract: Synthesis of 2‐(Dimethylallyl)‐N‐hydroxytryptophans from Indole.
Authors: PLATE R. , OTTENHEIJM H. C. J.
Published: May 2016

The indoles (I) react with the nitroso olefin (II) to yield the tricyclic derivatives (IV); (Ia) also produces the ring‐opening isomer (III).
ChemInform Abstract: A Direct, Regio‐ and Stereoselective 1α‐Hydroxylation of (5E)‐Calciferol Derivatives.
Authors: ANDREWS D. R. , BARTON D. H. R. , CHENG K. P. , FINET J.‐P. , HESSE R. H. , JOHNSON G. , PECHET M. M.
Published: May 2016

5E‐Calciferol‐Derivate wie (I) werden mit Se(IV)‐Verbindungen wie Seleniger Säure in" Pufferlösung definiert in die 1α‐Hydroxy‐Verbindungen (II) übergeführt.
ChemInform Abstract: Synthesis and Characterization of a New Semisynthetic Enzyme, Flavolysozyme.
Authors: ROKITA S. E. , KAISER E. T.
Published: May 2016

Hen egg white lysozyme is alkylated by the bromoacetyl compounds (I)‐(III).
ChemInform Abstract: Approach to the Aklavinone Series through a New High Pressure‐Induced [BCD‐‐>ABCD] Cycloaddition Strategy.
Authors: GUINGANT A. , D'ANGELO J.
Published: May 2016

The preparation of the dienes (IV) and (VII) and the tetracyclus (XI) is described.
ChemInform Abstract: An Efficient Synthesis of a Key Intermediate for Optically Active 5,6‐cis‐Carbapenem Antibiotics.
Authors: TAMURA N. , KAWANO Y. , MATSUSHITA Y. , YOSHIOKA K. , OCHIAI M.
Published: May 2016

The lactone (Ia) is silylated and then oxidized yielding the diol (II).
ChemInform Abstract: Marschalk Reaction Approach for a Simple Synthesis of (±)‐4‐Demethoxydaunomycinone.
Authors: ARGADE A. B. , MEHENDALE A. R. , AYYANGAR N. R.
Published: May 2016

Marschalk reaction of the leucoquinizarine (I) with the ketal aldehyde (II) produces the quinizarine (III), an intermediate in the synthesis of the (±)‐4‐demethoxydaunomycinone (IV).
ChemInform Abstract: Chromatographic Resolution. Part 10. Resolution of Enantiomers by HPLC on Cellulose trans‐ and cis‐Tris(4‐phenylazophenylcarbamate).
Authors: OKAMOTO Y. , SAKAMOTO H. , HATADA K. , IRIE M.
Published: May 2016

The cis‐trans‐isomerization of the cellulose carbaminates (I) on the surface of silica is investigated.
ChemInform Abstract: Uso of Noble Metals in Automobile Exhaust Catalysts
Authors: KUMMER J. T.
Published: May 2016

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ChemInform Abstract: [Sb3I10‐]∞ ‐ a Polymeric Anion with Transitions from Trigonal‐Pyramidal to Octahedral Coordination of Sb(III).
Authors: POHL S. , SAAK W. , MAYER P. , SCHMIDPETER A.
Published: May 2016

In the novel band‐like polymeric title anion, prepared as prism‐forming red salt (I) (PT) by crystallization from a solution of tris(dimethylamino)cyclopropenyliumiodide and SbI3 (1:3) in MeCN, 18 different Sb ‐I distances are observed.
ChemInform Abstract: Structures with Oligomeric Condensed Clusters in Indium Oxomolybdates.
Authors: SIMON A. , MERTIN W. , MATTAUSCH H. , GRUEHN R.
Published: May 2016

As demonstrated directly by high‐resolution TEM the novel compound In3Mo11O17 Contains Clusters of five linearly condensed Mo6O2 units with (In6)8‐ polyanions located between them.
ChemInform Abstract: Laser‐Induced Photoelectrochemistry on n‐ and p‐InP Electrodes.
Authors: COOK R. L. , DEMPSEY P. F. , SAMMELLS A. F.
Published: May 2016

Time‐resolved laser pulse photopotential and forward current measurements have been performed under open‐circuit conditions on single‐crystal n‐ and p‐InP as a function of electrolyte (1 M KOH and l M HClO4) and etchant (12 M HCl or 6:1 :l :1 HNO3:HCl:HOAc:HClO4) used on the photoelectrode surface.
ChemInform Abstract: A Solvated Electron Lithium Electrode for Secondary Batteries
Authors: SAMMELLS A. F. , SEMKOW K. W.
Published: May 2016

The novel liquid negative electrode consists of Li dissolved in liquid ammonia.
ChemInform Abstract: The Mechanism of Oxygen Reduction on Iron in Neutral Solutions.
Authors: JOVANCICEVIC V. , BOCKRIS J. O'M.
Published: May 2016

The O2 reduction has been investigated in a borate buffer on bare iron and on passive iron.
ChemInform Abstract: Palladium Electrode in Oxygen‐Saturated Aqueous Solutions. Reduction of Oxygen in the Activation‐Controlled Region.
Authors: VRACAR LJ. M. , SEPA D. B. , DAMJANOVIC A.
Published: May 2016

The kinetics of the electrochemical reduction of O2 at oxide‐free Pd has been studied in aqueous solution saturated under different O2 partial pressures over the pH range 0.2‐13.3 using steady‐state galvanostatic technique.
ChemInform Abstract: Formation and Decomposition Kinetic Studies of Calcium Zincate in 20 w/o KOH.
Authors: WANG Y.‐M. , WAINWRIGHT G.
Published: May 2016

The kinetics of the reactions Ahave been investigated (potential measurements) in order to study the effectiveness of Ca(OH)2 addition to Zn/NiOOH batteries in reducing zinc dendrite formation and shape change of the Zn electrode.
ChemInform Abstract: Electrochromic Properties of Sputtered Amorphous Films in the Systems WO3 ‐ Nb2O5 and Li2O ‐ WO3 ‐ Nb2O5
Authors: MACHIDA N. , TATSUMISAGO M. , MINAMI T.
Published: May 2016

have been studied by potentiostatic and galvanostatic measurements.
ChemInform Abstract: Dissolution of Glassy Ni‐P Alloys in H2SO4 and HCl Electrolytes.
Authors: DIEGLE R. B. , SORENSEN N. R. , NELSON G. C.
Published: May 2016

The anodic behavior of glassy Ni‐P in 0.2 N H2SO4 and 0.2 N HCl differs from that of Ni.
ChemInform Abstract: Synthesis, Characterization, and Crystal Structures of Two Scandium Cluster Carbides and a Boride, SC7X12C (X: I, Br) and Sc7I12B.
Authors: DUDIS D. S. , CORBETT J. D. , HWU S.‐J.
Published: May 2016

The structures of the isomorphous Carbides (I) and (III), which are synthesized as outlined in the sCheme, are re‐ fined in the acentric space group R3 (Z=3).
ChemInform Abstract: Structural and Conformational Studies on Sesquiterpenoid Esters from Laserpitium halleri Crantz subsp.
Authors: APPENDINO G. , VALLE M. G. , GARIBOLDI P.
Published: May 2016

The two pairs of germacrane esters (Ia) and guaiane esters (II) as well as the daucane derivative vaginatin (III) are isolated from the ripe fruits of Laserpitium halleri.
ChemInform Abstract: Inverted Tricoordinate Carbon.
Authors: LAMMERTSMA K.
Published: May 2016

The 6‐31G* energies, structural parameters, and Mulliken overlap population analysis for the four‐membered ring structures (I) and (II) are discussed in terms of stability properties associated with inverted tricoordinate carbons.
ChemInform Abstract: Cobalt(II) Halide Complexes in Aqueous Ammonium Nitrate
Authors: KERRIDGE D. H. , NIKOLIC R. , STOJIC D.
Published: May 2016

Calcium Nitrate Melts: Electronic Spectra and Solvent Extraction.
ChemInform Abstract: 13C NMR Study of Complexes Involving Zinc(II) and 2,2′,2"‐Triaminotriethylamine.
Authors: DAGNALL S. P. , HAGUE D. N. , MORETON A. D.
Published: May 2016

13C NMR spectra are reported as a function of pH for mixtures of the title ligand and zinc nitrate and/or chloride alone or with additional bidentate ligands.
ChemInform Abstract: Binding Ability of Acetamide Oxime with Proton, Copper(II), and Dioxouranium(VI) in Aqueous Solutions.
Authors: HIROTSU T. , KATOH S. , SUGASAKA K. , SENO M. , ITAGAKI T.
Published: May 2016

The equilibrium constant of the title ligand with proton in aqueous solutions is determined using the potentiometric method.
ChemInform Abstract: Efficient Electrocatalytical Acetalization of Aliphatic Aldehydes.
Authors: GORA J. , SMIGIELSKI K. , KULA J.
Published: May 2016

The aliphatic aldehydes (I) are electrocatalytically acetalized by the alcohols (II) at a platinum or carbon anode with sodium p‐toluene sulfonate as the Supporting electrolyte.
ChemInform Abstract: Reaction of 1,4‐Bis(bromomagnesio)pentane and 1,5‐Bis(bromomagnesio)hexane with Carboxylic Acid Esters.
Authors: CANONNE P. , BERNATCHEZ M.
Published: May 2016

Die Bis‐Grignard‐Verbindungen (Ia) und (Ib) reagieren mit den Estern (II) zu den Cycloalkanolen (III) und (IV) bzw. (V) und (VI), wobei die trans‐Diastereomeren (IV) und (VI) bevorzugt gebildet werden.
ChemInform Abstract: Novel Substituted 1,2‐Oxathietanes from Competing Cyclizations of 2‐Chloroethyl Sulfoxide Precursors. Observation of Vinylogous 1,4‐Halogen Participation in 1,2‐Oxathietane Generation.
Authors: LOWN J. W. , KOGANTY R. R. , NAGHIPUR A.
Published: May 2016

Die unter spontaner Zersetzung ablaufende Hydrolyse des Chlorethylsulfinyl‐N‐nitrosoharnstoffs (II) führt zu einem Produktgemisch der Verbindungen (III)‐(IX), deren Bildung diskutiert wird.
ChemInform Abstract: Photochemical Studies of Porphyrin ‐ Melanin Interactions.
Authors: BIELEC J. , PILAS B. , SARNA T. , TRUSCOTT T. G.
Published: May 2016

Laser flash photolysis and ESR as well as conventional absorption and spectrofluorimetry are used to study the interaction of anionic, neutral and cationic porphyrin dyes with two synthetic melanins obtained by polymerising dihydroxyphenylalanine (dopa) and 5‐S‐ cysteinyldopa.
ChemInform Abstract: The Quenching of Aromatic Ketone Triplets by Oxygen: Competing Singlet Oxygen and Biradical Formation?
Authors: GORMAN A. A. , RODGERS M. A. J.
Published: May 2016

Singlet oxygen, !Δg, has been produced by pulsed laser excitation of benzophenone, acetophenone, 3′‐methoxyacetophenone, and 2‐acetonaphthone in benzene and acetonitrile.
ChemInform Abstract: Stable Polycyclic Anions: Dianions from Overcrowded Ethylenes.
Authors: COHEN Y. , KLEIN J. , RABINOVITZ M.
Published: May 2016

The bifluorenylidene derivatives (I) are cqnverted to the dianions (II) by reduction with metallic sodium or potassium.
ChemInform Abstract: Reactions of Singlet Oxygen with Enol Esters.
Authors: WILSON S. L. , SCHUSTER G. B.
Published: May 2016

Die Photooxygenierung der Enolester (1), (IV) und (VI) mit Singulett‐ Sauerstoff (II) führt zu den im Formelschema angegebenen Produkten.
ChemInform Abstract: The Mechanism of Hydrogenation by Aqueous Chromium(II) Ion of the Carbon‐Carbon Double Bond of Olefinic Compounds with Polar Substituents.
Authors: KATAKIS D. , VRACHNOU‐ASTRA E. , KONSTANTATOS J.
Published: May 2016

The kinetics of the reaction of Cr2+ with the acids (I) and (II) are investigated over a wide range of concentrations.
ChemInform Abstract: The First Stereospecific Catalytic Hydrogenation with a Polymer Supported Optically Active Rhodium Complex.
Authors: NAGEL U. , KINZEL E.
Published: May 2016

The amino silane (I) is converted to the amides (II), which then react with the bis(phosphino)pyrrolidine (III) yielding the bisamides (IV).
ChemInform Abstract: Cyanogen Bromide as a Useful Brominating Agent. Synthesis of α‐Bromo‐β‐amino‐ enones.
Authors: ALBEROLA A. , ANDRES C. , ORTEGA A. G. , PEDROSA R. , VICENTE M.
Published: May 2016

Die im Titel genannten Verbindungen (III) werden aus den β‐Aminoenonen (I) und Bromcyan (II) erhalten.
ChemInform Abstract: A Theoretical Study of Atomic Sulfur Reactions with Alkanes, Alkenes, and Alkynes.
Authors: MCKEE M. L.
Published: May 2016

The results of an MNDO study of the potential energy surface for reaction of Sulfur in its ground S(3P) and first excited state S(′ D) with alkanes, alkenes, and alkynes are reported.
ChemInform Abstract: Acylation of Aromatic Compounds in the Presence of Sulfodifluoro Acetic Acid.
Authors: GANDEL'SMAN L. Z. , NAZARETYAN V. P. , KHOMENKO L. A. , YAGUPOL'SKII L. M.
Published: May 2016

Sulfodifluoressigsäure (IIIa) oder ihr Methylester (IIIb) katalysieren die Acylierung der Aromaten (I) zu den Ketonen (IV).
ChemInform Abstract: Novel Method for the Synthesis of Organic Perchlorates by Oxidation of Alkenes in the System Pb4+ ‐ Cl‐ ‐ HClO4 ‐ CH3COOH.
Authors: SERGUCHEV JU. A. , GUTSULYAK R. B.
Published: May 2016

Behandlung der Alkene (I) mit Blei(IV)‐Verbindungen in Perchlorsäure/ Eisessig in Gegenwart von Chlorid‐Ionen führt zu den Perchloraten (II) neben den Acetaten (III) und den vicinalen Dichlorverbindungen (IV).
ChemInform Abstract: The Chemistry of α‐Silyl Carbonyl Compounds. Part 12. A Synthesis of 4‐Oxo Carboxylic Acids, 4‐Oxo Aldehydes, and 1,4‐Diketones from γ‐Lactones.
Authors: BETANCOURT DE PEREZ R. M. , FUENTES L. M. , LARSON G. L. , BARNES C. L. , HEEG M. J.
Published: May 2016

Die α‐silylierten Lactone (I) reagieren mit den Grignard‐Verbindungen (II) zu den Dihydrofuranen (III).
ChemInform Abstract: Reaction of O‐Sily1‐Substituted Enols with N‐Methyl‐N‐chloromethylmethanesulfon‐ amide.
Authors: SHIPOV A. G. , ARTAMKINA O. B. , LIVANTSOVA L. I. , BAUKOV YU. I.
Published: May 2016

Das aus dem N‐Methylmethansulfonamid (I) durch Umsetzung mit Paraformaldehyd/Trimethylchlorsilan hergestellte N‐Methyl‐N‐chlormethylmethansulfonamid (II) reagiert in Gegenwart von Titantetrachlorid mit den Silylenolethern (III) unter C‐Alkylierung zu den Verbindungen (IV).
ChemInform Abstract: Preparation of Hydrazides Using Silicon Tetrachloride as Coupling Agent.
Authors: KORNET M. J. , TITA T. T. , THIO A. P.
Published: May 2016

Die Hydrazide (III) werden durch Reaktion der Carbonsäuren (I) mit den Hydrazinen (II) in Gegenwart von Tetrachlorsilan in Pyridin erhalten.
ChemInform Abstract: Preparation of Diaryl Ethers from Tyrosine or 4‐Hydroxyphenylglycine Using Organomanganese Chemistry.
Authors: PEARSON A. J. , BRUHN P. R. , HSU S.‐Y.
Published: May 2016

Die optisch aktiven phenolischen Aminosäureester (II) werden mit dem Mangan‐Komplex (I) ohne nachweisbare Racemisierung zu den Diarylethern (III) umgesetzt.
ChemInform Abstract: Preparation of a New Type of Electron‐Deficient Olefins: β‐Phenylthio Nitro Olefins, β‐Sulfinyl Nitro Olefins, and β‐Sulfonyl Nitro Olefins.
Authors: ONO N. , KAMIMURA A. , KAJI A.
Published: May 2016

Ausgehend von den Nitroalkylacetaten (I) werden die Phenylthio‐nitroolefine (IV) hergestellt, die zu den Sulfonen (V) bzw. Sulfoxiden (VI) oxidiert werden.
ChemInform Abstract: Preparation of Chiral β‐Hydroxyketones by Aldol‐Type Condensation of Chiral p‐ Tolylsulfinylmethyl Ketones.
Authors: SCHNEIDER F. , SIMON R.
Published: May 2016

The optically pure p‐tolylsulfinyl methyl ketones (IV) are synthesized by decarboxylation of the Chiral sulfinyl ketoesters (III) formed by the reaction of (S)‐menthyl p‐toluene sulfinate (I) with the bisanions of the methyl acetocarboxylates (II).
ChemInform Abstract: Phase Transfer Controlled Selective Oxidation of Diarylsulfides to Diarylsulfoxides Using Potassium Hydrogen Persulfate.
Authors: EVANS T. L. , GRADE M. M.
Published: May 2016

Die Diarylsulfide (I) werden unter Phasen‐Transfer‐Bedingungen durch Kaliumhydrogenpersulfat bevorzugt zu den Diarylsulfoxiden (II) oxidiert, die Sulfone (III) entstehen nur als Nebenprodukte.
ChemInform Abstract: 2‐Substituted 1,3‐Benzoxathiolium Tetrafluoroborates as Efficient Acylating Agents for N,N‐Dialkylarylamines.
Authors: CADAMURO S. , DEGANI I. , FOCHI R. , GATTI A. , REGONDI V.
Published: May 2016

The reaction of 1,3‐benzoxathiolium salts (I) with N,N‐dialkylarylamines (II) selectively yields the p‐substituted anilines (III) which are hydrolyzed to form the ketones (IV).
ChemInform Abstract: The Stereoselectivity of the Anodic Acetoxylation of Double Bonds.
Authors: DELAUNAY J. , SIMONET J. , TOUPET L.
Published: May 2016

Anodic oxidation of 2,3‐diphenyl‐indenone (I) in the presence of acetate produces the isomeric adducts (II) and (III).
ChemInform Abstract: Cyclization of N‐Substituted 2,2‐Diarylglycolohydroxamic Acids to 1,2‐Oxazetidin‐3‐ones.
Authors: LAUTERBACH T. , GEFFKEN D.
Published: May 2016

The hydroxamic acids (Ia)‐(Ii) react directly with CDI (II) to give the oxazetidines (IVa)‐(IVi) while the acids (Ij)‐(Il) yield the dioxazinanes (IIIj)‐(IIII) which undergo ring contraction in the presence of molecular sieves to give (IVj)‐(IVl).
ChemInform Abstract: Strategy and Construction of the Backbone Bistetrahydrofuran System Towards Synthesis of Rollinicin.
Authors: RAO A. V. R. , KRISHNAPPA S. , REDDY K. L. N. , REDDY K. A.
Published: May 2016

Als Modell für den Aufbau des in den antibiotisch und antitumor‐wirksamen Pflanzeninhaltsstoffen Rollinicin (Xa), Uvaricin (Xb) und Cherimolin (Xc) vorkommenden Bis‐tetrahydrofuran‐Gerüstes wird nach der im Schema angegebenen Reaktionsfolge das Bis‐tetrahydrofuran (IX) synthetisiert.
ChemInform Abstract: Synthesis of Various New Nitroxide Free Radical Fatty Acids.
Authors: HIDEG K. , LEX L.
Published: May 2016

A generally applicable method is presented for the synthesis of various new nitroxide fatty acids such as (X)‐(XII) which are to be used for biological spin labeling studies.
ChemInform Abstract: 3‐Hydroxypyrroles and 1H‐Pyrrol‐3(2H)‐ones. Part 1. Formation and X‐Ray Crystal and Molecular Structure of 1‐Cyclohexyl‐2,2‐pentamethylene‐1H‐pyrrol‐3(2H)‐one.
Authors: HICKSON C. L. , KEITH E. M. , MARTIN J. C. , MCNAB H. , MONAHAN L. C. , WALKINSHAW M. D.
Published: May 2016

The title compound (IV) is synthesized by the pyrolysis of (Ib) which is, like (Ic) and (Id), obtained from Meldrum′s acid (II) (46‐67°C /o).
ChemInform Abstract: Oxymetalation. Part 20. Conversion of Cyclopropanes into 1,2‐Dioxolanes via tert‐ Butyl Peroxymercuriation, Bromodemercuriation, and Silver Salt Induced Cyclization.
Authors: BLOODWORTH A. J. , CHAN K. H. , COOKSEY C. J.
Published: May 2016

Die Cyclopropane (I) werden durch Peroxymercurierung zu (II), anschlie‐ βende Bromolyse zu (III) und nachfolgende Umsetzung mit Silbertrifluoracetat in die 1,2‐Dioxolane (IV) übergeführt.
ChemInform Abstract: Oxidation of 3‐Acetyl‐5‐methylthio‐2‐phenyl‐2,3‐dihydro‐1,3,4‐thiadiazole with m‐ Chloroperbenzoic Acid and Nucleophilic Substitution of the Oxidation Product, 3‐Acetyl‐5‐methylsulphinyl‐2‐phenyl‐2,3‐dihydro‐1,3,4‐thiadiazole. X‐Ray Molecular Structure of (2S*)‐3‐Acetyl‐5‐[(R*)‐methylsulphinyl]‐2‐phenyl‐2,3‐dihydro‐1,3,4‐thiadiazole and of (1R*,2S*)‐3‐Acetyl‐5‐[(S*)‐methylsulphinyl]‐2‐phenyl‐2,3‐dihydro‐1,3,4‐thiadiazole 1‐Oxide.
Authors: KUBOTA S. , TOYOOKA K. , SHIBUYA M. , TAIRA Z.
Published: May 2016

The title compound (I) can be reduced in one step with three equiv. MCPBA (CHCl3, 20°C, 1 h) to give (VI) (yield 93%).
ChemInform Abstract: Condensation of 3‐Acetyl‐ and 3‐Acetyl‐4‐methyl‐2H‐1‐benzopyran‐2‐one with Aromatic Aldehydes.
Authors: DIMITROVA E. , ANGHELOVA Y.
Published: May 2016

3‐Acetyl‐benzopyran‐2‐on (I) wird mit den Benzaldehyden(II) zu den Chalkonen (III) kondensiert.
ChemInform Abstract: Oxidation of a Vitamin E Model Compound, 2,2,5,7,8‐Pentamethylchroman‐6‐ol, with the tert‐Butylperoxyl Radical.
Authors: MATSUMOTO S. , MATSUO M. , IITAKA Y. , NIKI E.
Published: May 2016

The chroman‐6‐ol (I), a model compound for Vitamin E, reacts with tert‐ butoxy radicals, generated e.g. from di‐tert‐butylperoxy oxalate (II), to produce the peroxo derivatives (IV) and (V).
ChemInform Abstract: Pyridines by Cyano[4 + 2]Cycloaddition.
Authors: POTTHOFF B. , BREITMAIER E.
Published: May 2016

The 2‐ethoxycarbonylpyridines (IV) and (V) are prepared by cobalt‐catalyzed cycloaddition reactions of ethyl cyanoformate (II) and the 2‐alkyl‐1‐ethoxy‐1,3‐butadienes (I).
ChemInform Abstract: A Convenient Synthesis of Methyl (E)‐β‐Pyrimidinylacrylates.
Authors: WADA A. , YAMAMOTO J. , HASE T. , NAGAI S. , KANATOMO S.
Published: May 2016

The reactions of the 5‐halopyrimidines (I) with methyl acrylate (II) under palladium catalysis yields the methyl (E)‐β‐pyrimidinyl acrylates (III).
ChemInform Abstract: Trimethylsilyl Esters of (ω‐(N,N‐Dialkylamino)alkanoic Acids.
Authors: VORONKOV M. G. , VVEDENSKII V. YU.
Published: May 2016

Die (o‐Bromalkancarbonsäuren (I) reagieren mit Dialkylaminotrimethylsilan (II) und Methanol zu den Silylestern (IV).
ChemInform Abstract: Reactions of Chloromethyldimethylchlorosilane with Silicon Derivatives of Hydroxycarbamic Acid, Carbodiimide, and Ammonia.
Authors: SHELUDYAKOV V. D. , LEBEDEVA A. B. , SHUKYUROV A. KH. , KIRILIN A. D.
Published: May 2016

Die Trimethylsilylderivate der N‐ Hydroxycarbaminsäure, des Carbodiimids und des Ammoniaks (I), (V) und (VIII) reagieren mit Chlormethyldimethylchlorsilan (II) unter teilweiser oder vollständiger Umsilylierung.
ChemInform Abstract: Synthesis of α‐Fluoroalkylphosphonates.
Authors: BLACKBURN G. M. , PARRATT M. J.
Published: May 2016

The lithiated carbanion of the fluoromethylphosphonate (I) adds to a variety of aldehydes and ketones leading to α‐fluoro‐β‐hydroxyalkylphosphonates as (IIa)‐(IIc) with two new chiral centres and in the case of acet‐ or paraformaldehyde also or only to the α‐fluorovinyl derivatives (III).
ChemInform Abstract: Reaction of Chloro‐Substituted Methyldichlorophosphines with Triethylorthoformate.
Authors: LIVANTSOV M. V. , PRISHCHENKO A. A. , LUTSENKO I. F.
Published: May 2016

Die Chlor‐substituierten Methyldichlorphosphine (I), (IV) und (VIII) reagieren mit Orthoameisensäuretriethylester (II) je nach Halogenierungsgrad zu den Phosphinsäureestern (III) und (VII) bzw. den Phosphonigsäurederivaten (V), (VI) und (IX).
ChemInform Abstract: Esterchlorides of Di‐ and Trichloromethanephosphonic Acids.
Authors: BLINOVA G. G. , LAVRENT'EV A. N. , MEL'NIKOVA L. N. , PANOVA L. A.
Published: May 2016

Die Chlormethanphosphonsäuredichloride (I) bilden mit den Alkoholen (II) in Gegenwart von Triethylamin die Monoesterchloride (III).
ChemInform Abstract: On the Ternary Thiophosphoryl‐mercapto Ylide Tautomerism. Part 3. Synthesis and Structure of [(Diphenylthiophosphoryl)acetylmethyl]triphenylphosphonium Salts.
Authors: ALADZHEVA I. M. , LEONT'EVA I. V. , PETROVSKII P. V. , MASTRYUKOVA T. A. , KABACHNIK M. I.
Published: May 2016

Aus dem Diphenylchlorphosphin (I) wird durch Umsetzung mit dem Acetylmethylenphosphoran (II) das Diphenylphosphin‐substituierte Phosphoran (III) hergestellt und mit Schwefel in das Thiophosphorylderivat (IV) übergeführt.
ChemInform Abstract: Acetylene‐Allene Rearrangement in Arbuzov Reaction of Dialkyl Esters of Phenylphosphonous Acid with Propargylic Bromide.
Authors: ABDULGANEEVA S. A. , ERZHANOV K. B. , SADYKOV T. S.
Published: May 2016

Bei der Umsetzung von Phenylphosphonigsäureestern (I) mit überschüssigem Propargylbromid (II) entstehen Gemische der Phosphinsäureester (III)‐(VI).
ChemInform Abstract: Stereochemistry of 1,2‐Oxaphospholanes. Part 8. Synthesis, Stereochemistry, and Ring Opening Reactions of Diastereomeric 3‐Hydroxy‐2‐methoxy‐5‐methyl‐1,2‐oxaphospholan‐2‐ones.
Authors: WROBLEWSKI A. E.
Published: May 2016

Addition of dimethyl phosphonate to acetaldol (I) gives a mixture of the diastereomeric phosphonates (IIa) and (IIb).
ChemInform Abstract: Reactive E = C(p‐p)π‐Systems. Part 10. Preparation and Reactivity of Perfluoro‐ 3‐phosphapent‐2‐ene.
Authors: GROBE J. , SZAMEITAT J.
Published: May 2016

The title compound (II) is prepared for the first time by thermal elimination of Me3SnF from the stannyl‐bis(perfluoroethyl)phosphane (I).
ChemInform Abstract: Reactions of Bis(1,1,3‐trihydroperfluoropropyl)phosphorous Acid Derivatives with Carbonyl Compounds.
Authors: KONOVALOVA I. V. , BURNAEVA L. A. , KHUSNUTDINOVA E. K. , PUDOVIK A. N.
Published: May 2016

Bis‐(trihydroperfluorpropyl)‐isocyanato‐phosphit (I) reagiert mit Benzil oder Phenylglyoxylsäureethylester (II) zu den 1,3,2‐Oxa‐azaphospholenen (III).
ChemInform Abstract: 1‐Aminodiazaphosphene, Synthesis, Crystal Structure, Bonding Properties, and Reactivity of a Derivative.
Authors: DRESSLER U. , NIECKE E. , POHL S. , SAAK W. , SCHOELLER W. W. , SCHAEFER H.‐G. +
Published: May 2016

The amino dichlorophosphane (I) reacts with lithium bis(trimethylsilyl)amide (II) producing the intermediate (III).
ChemInform Abstract: Formation of Dimeric Acetylenes: An Unexpected Reaction of Acetylenic Selenides.
Authors: COMASSETO J. V. , CATANI V. , FERREIRA J. T. B. , BRAGA A. L.
Published: May 2016

The selenoalkynes (Ib)‐(Id) react with MCPBA to produce the dimeric acetylenes (IIb)‐(IId).
ChemInform Abstract: Evidence for Carbon ‐ Hydrogen ‐ Titanium Interactions: Synthesis and Crystal Structures of the Agostic Alkyls [TiCl3(Me2PCH2CH2PMe2)R] (R: Et or Me).
Authors: DAWOODI Z. , GREEN M. L. H. , MTETWA V. S. B. , PROUT K. , SCHULTZ A. J. , WILLIAMS J. M. , KOETZLE T. F.
Published: May 2016

The title Compounds (I) and (II) are prepared by reaction of the alkylated Ti(IV) chlorides TiCl3R in light petroleum with an excess or equimolar amounts of the diphosphine (at ‐ 15 to + 20°C).
ChemInform Abstract: Unusual Minicyclic Macrocyclic Sandwich Complex of Titanium(III) Containing Cyclopentadienyl and Tetramethyldibenzocyclotetradecane (C22H22N42‐) Ligands.
Authors: YANG C.‐H. , GOEDKEN V. L.
Published: May 2016

The titanium Chloride (I) is condensed with cyclopentadienyl sodium (II) to produce the mixed sandwich complex (III).
ChemInform Abstract: Synthesis, Characterization, and Crystal Structure of μ‐[1′‐Pyrrolidinecarbodithioato‐S(Bi1,2)S′(Bi2)]‐1,1,1,2,2‐pentakis(l′‐pyrrolidinecarbodithioato‐SS′)dibismuth(III) Ethanol (1/l)and of Di‐μ‐chloro‐bis[bis(1‐pyrrolidinecarbodithioato‐ SS′)(thiourea‐S)bismuth(III)].
Authors: BATTAGLIA L. P. , BONAMARTINI CORRADI A.
Published: May 2016

The title Compounds (I) and (II) are synthesized by 1:3 molar reaction of BiCl3 and ammonium pyrrolidinecarbodithioate in CH2Cl2 ‐ EtOH, or by grinding of BiCl3 and thiourea (ratio 1:3) and reacting with an excess of the pyrrolidinedithioate in CH2Cl2‐ EtOH.
ChemInform Abstract: Synthesis of (Chloro)η3‐2‐chloromethylallyl(bis‐acetonitrile)dicarbonylmolybdenum(II).
Authors: BAKER P. K.
Published: May 2016

The air‐ and thermally sensitive title complex (II) is prepared by the two‐step process shown and characterized spectroscopically (IR, 1H NMR).
ChemInform Abstract: Preparation and Studies of Paramagnetic Diene Complexes of Molybdenum(III).
Authors: DAVIDSON J. L. , DAVIDSON K. , LINDSELL W. E. , MURRALL N. W. , WELCH A. J.
Published: May 2016

Reactions of the coordinatively unsaturated alkyne complexes (I) with butadiene, isoprene, or trans‐ 1 ,3‐pentadiene give the paramagnetic diene‐Mo(III) complexes (II) which are characterized by elemental analysis, IR and MS spectrometry.
ChemInform Abstract: Instant Ligands. Part 1. Preparation of Some Bidentate Fluorophosphine Ligands Derived from Straight Chain Organic Substrates, and Their Reactions to Form Molybdenum Complexes.
Authors: BELL G. A. , RANKIN D. W. H.
Published: May 2016

The Compounds (II) are prepared by condensation reactions of S(PF2)2 with the appropriate dithiols and diols (I), and characterized by NMR and IR‐ spectroscopic data.
ChemInform Abstract: Chemistry of Di‐ and Tri‐metal Complexes with Bridging Carbene or Carbyne Ligands. Part 43. Carbon ‐ Tungsten Triple Bonds as Formal Font‐electron Donors; Synthesis and Reactions of the Compounds [FeW(μ‐CC6H4Me‐4)(CO)5L] {L: HB(pz)3 [Tris(pyrazol‐1‐yl)borate] or η‐C5H5} and X‐Ray Crystal Structures of [FeW(μ‐CC6H4Me‐4)(CO)5{HB(pz)3}] and [FeW(μ‐CC6H4Me‐4)‐(μ‐CO)(μ‐ Me2PCH2PMe2)(CO)2{HB(pz)3}].
Authors: GREEN M. , HOWARD J. A. K. , JAMES A. P. , DE M. JELFS A. N. , NUNN C. M. , STONE F. G. A.
Published: May 2016

The carbyne‐W complex (Ia) reacts with Fe2(CO)9 to give the p‐tolylmethylidyne‐bridged Fe ‐ W complex (IIa).
ChemInform Abstract: Equatorial and Axial Ligand Effects in Square Planar Co(II) Complexes Catalysing the Oxidation of 1‐Phenylethan‐1‐ol to Acetophenone.
Authors: BECKETT M. A. , HOMER R. B.
Published: May 2016

Square planar Co(II) complexes of tetradentate ligands catalyse the Oxidation of secondary alcohols to ketones in the presence of an axial ligand Band O2.
ChemInform Abstract: Template Preparation of a Nickel(II) Pyridinophane Complex; Crystal and Molecular Structure of cis‐Dichloro{2,11‐dithia[3,3](2,6)pyridinophane}nickel(II).
Authors: CONSTABLE E. C. , LEWIS J. , MARQUEZ V. E. , RAITHBY P. R.
Published: May 2016

The dimeric Ni(II) complex (I), prepared from hydrated Ni(II) sulfate and 2,6‐bis(mercaptomethynpyridine in the presence of aqueous NH; as a dihydrate, reacts with 2,6‐bis(bromomethyl)pyridine to give the macrocyclic cis‐dibromo complex (IIa).
ChemInform Abstract: Effect of Deprotonation of the Coordinated Water Molecule on Properties of Copper(II) Complex with Glycylglycine and H2O.
Authors: SATO M. , MATSUKI S. , IKEDA M. , NAKAYA J.‐I.
Published: May 2016

The properties of (I) in aqueous solution are studied using potentiometric titration, ESR spectroscopy, and polarography, to see the effect of deprotonation at the coordinated H2O. The deprotonated complex (II) was produced abopve pH 8 in solution, but was reduced only above pH 10.5.
ChemInform Abstract: Decomposition Reactions of Dimethyl‐di‐p‐methylene‐bis(η‐pentamethylcyclopentadienyl)dirhodium and Their Relation to the Mechanism of the Fischer‐Tropsch Reactions; the Formation of Propylene from Three C1 Ligands.
Authors: SAEZ I. M. , MEANWELL N. J. , NUTTON A. , ISOBE K. , VAZQUEZ DE MIGUEL A. , BRUCE D. W. , OKEYA S. , ANDREWS D. G. , ASHTON P. R. , JOHNSTONE I. R. , MAITLIS P. M.
Published: May 2016

Thermal decomposition of (I) at temp. from 275 to 375°C yields mainly methane and propylene with smaller amounts ofethylene(10‐20°C /o)and ethane (1‐3°C /o).
ChemInform Abstract: Reduction‐Oxidation Properties of Organotransition‐metal Complexes.
Authors: CONNELLY N. G. , RAVEN S. J.
Published: May 2016

The 1:2 molar reaction of the corresponding transition metal carbonyls with C5Ph5Br (I) and Zn dust in THF leads to the neutral cyclopentadienyldicarbonyl complexes (II).
ChemInform Abstract: Synthesis, Spectroscopic, and Structural Studies of the Methylpalladium(II) Complexes [{PdMe(SMe2)X}2] (X: Cl, Br, or I); Crystal Structure of trans‐[{PdMe(SMe2)(μ‐Cl)}2].
Authors: BYERS P. K. , CANTY A. J. , ENGELHARDT L. M. , WHITE A. H.
Published: May 2016

The reaction of the trans‐dihalo complexes (Ia), (Ib) with halide‐free LiMe leads to the corresponding title complexes (IIa), (IIb).
ChemInform Abstract: Metal Complexes of the Antibiotic Nalidixic Acid.
Authors: BARBA BEHRENS N. , MENDOZA DIAZ G. , GOODGAME D. M. L.
Published: May 2016

The Complexes (I)‐(IV) are prepared by reaction of corresponding metal salts with sodium salt of the title compound HL in stoichiometric ratios.
ChemInform Abstract: Reactions of Platinum(II) Carboxylate Complexes with Tertiary Phosphines and Chlorinated Solvents.
Authors: ANDERSON G. K. , LUMETTA G. J.
Published: May 2016

The reactions of the Pt(II) carboxylates (I) and (II) with . tert. phosphines are investigated by means of 31P 1H NMR spectroscopy.
ChemInform Abstract: Carbon ‐ Chlorine Bond Activation in 2‐Chloromethylallyl Complexes of Platinum(II).
Authors: KEMMITT R. D. W. , PLATT A. W. G.
Published: May 2016

Treatment of the Pt(0) complex (I) with 3‐chloro‐2‐chloromethylprop‐1‐ene (II) and KPF6 affords the n3‐(2‐chloromethyl)allyl‐Pt(II) complex (IIIa).
ChemInform Abstract: Chemistry of Di‐ and Tri‐metal Complexes with Bridging Carbene or Carbyne Ligands. Part 45. Synthesis of the Pentanuclear Metal Complexes [M′M2Re2(μ‐CC6H4Me‐4)2(CO)18] (M′: Ni or Pt, M: Cr or W) and Related Compounds; X‐Ray Crystal Structure of [ReWPt(μ‐CC6H4Me‐4)(CO)9(PMe3)2].
Authors: JEFFERY J. C. , LEWIS D. B. , LEWIS G. E. , PARROTT M. J. , STONE F. G. A.
Published: May 2016

The pentanuclear metal Compounds (II) are prepared by treating the binuclear alkyne Complexes (I) with Pt(C2H4)3 or Ni(COD)2.
ChemInform Abstract: Synthesis, Spectral Behaviour and Biological Activity of Benzoxazonyl‐(quinoxalonyl)benzfurano(indolo)quinoline Apocyanine Dyes.
Authors: KHALIL Z. H. , KORAIEM A. I. M. , EL‐MAGHRABY M. A. , ABU‐EL‐HAMD R. M.
Published: May 2016

The benzoxazine or quinoxaline derivatives (V) are prepared as shown in the reaction scheme and coupled with (VI) to yield the benzofurano or indolo compounds (VII).
ChemInform Abstract: Structure Elucidation of Two Triterpenoid Tetrasaccharides from Androsace saxifragifolia.
Authors: WALTHO J. P. , WILLIAMS D. H. , MAHATO S. B. , PAL B. C. , BARNA J. C. J.
Published: May 2016

Two glycosides called saxifragifolin A (Ia) and B (Ib) are isolated from the ethanolic extract of the small herb Androsace saxifragifolia.
ChemInform Abstract: Regioselectivity of the Reaction of 3‐Keto Steroids with Potassium Superoxide.
Authors: ALVAREZ E. , FRANCISCO C. G. , FREIRE R. , HERNANDEZ R. , SALAZAR J. A. , SUAREZ E. , BETANCOR C.
Published: May 2016

KO2 oxidizes the cholestanone (I) to give the lactol (II) [which is ring‐opened on treatment with diazomethane or LiAlH4 to afford the ester (III) and the diol (IV), resp.], whereas oxidation‐methylation of the androstanone (V) under the same conditions leads to the oxo‐esters (VI) and (VII) in equal parts.
ChemInform Abstract: An Improved Method for the Synthesis of 2‐Acetoxysteroid‐4‐en‐3‐ones.
Authors: OHNISHI S. , OSAWA Y.
Published: May 2016

The 2‐acetoxy‐steroid‐4‐en‐3‐ones (III) and (IV) are obtained in a onestep synthesis by oxidizing the enones (I) with lead tetraacetate (II) in dry benzene.
ChemInform Abstract: An Efficient One‐Pot Synthesis of N‐Protected α‐Amino‐β‐dialkoxyphosphinyloxy‐ (diphenoxyphosphinyloxy)carboxylic Acids (Phosphate‐Group Esters of O‐Phosphorylated N‐Protected α‐Amino‐β‐hydroxyamino Acids).
Authors: PERICH J. W. , ALEWOOD P. F. , JOHNS R. B.
Published: May 2016

The N‐protected serines (I), threonines (IV), and tyrosines (VI) are readily phosphitylated by the dialkyl or diphenyl phosphorochlorides (II) in the presence of pyridine.
ChemInform Abstract: Building Units of Oligosaccharides. Part 73. Synthesis of the Tetrapeptide Sequence 12 to 15 of Asialoglycophorin A with Four Disaccharide Side Chains.
Authors: PAULSEN H. , SCHULTZ M.
Published: May 2016

To accomplish the synthesis of the title compound (IX), first the units (Ib), (Ic), (IVc) are prepared a) from the known compound (Ia) or b) from the components (II) and (III) via the azide (IVa) and the reduction/acetylation product (IVb), respectively.
ChemInform Abstract: Synthesis of a Morphinan from a Benzocyclobutene Derivative. X‐Ray Structure of 3,3‐Ethylenedioxy‐1,2,3,4,4a,10aα‐hexahydro‐6,7‐dimethoxyphenanthrene‐4aβ‐carbonitrile.
Authors: KAMETANI T. , SUZUKI Y. , HONDA T.
Published: May 2016

A stereoselective synthesis of a morphinan ring system is achieved by employing an intramolecular Diels‐Alder reaction of the benzocyclobutene derivative (III) to provide the tricyclic compounds (IV) with A/B cis ring junction.
ChemInform Abstract: Application of the New Acylating Agents [PhS(O)‐CH = C(OMe)Cl and PhSO2 ‐CH = C(OMe)Cl] to the Synthesis of Indole Alkaloids. A Total Synthesis of (±)‐Aspidofractinine.
Authors: KINOSHITA H. , OHNUMA T. , OISHI T. , BAN Y.
Published: May 2016

The application of the acylating agents (I) or (II) in the synthesis of the indole alkaloid (IV) is described.
ChemInform Abstract: Phytochemical Examination of the Lichen, Lecanora gangaleoides Nyl.
Authors: DEVLIN J. P. , MAHANDRU M. M. , OLLIS W. D. , SMITH C.
Published: May 2016

Six compounds are isolated from the lichen Lecanora gangaleoides Nyl.
ChemInform Abstract: Comparison of Phosphosilicate Glass Films Deposited by Three Different Chemical Vapor Deposition Methods
Authors: SHIOYA Y. , MAEDA M.
Published: May 2016

1. plasma CVD (13.56 MHz), 2. low‐pressure CVD(LPCVD), and 3. atmospheric CVD.
ChemInform Abstract: Thermodynamics and Vaporization Chemistry in the PbS‐Ga2S3 System.
Authors: WILLIAMSON M. A. , EDWARDS J. G.
Published: May 2016

The vaporization reactions observed in the title system and their average third‐law AH° (298 K) values are outlined below.
ChemInform Abstract: Interaction Between Non‐Conjugated Chromophores. Part 26. Control of the Diels‐ Alder‐Addition Regioselectivity by Remote Olefins.
Authors: BURNIER G. , SCHWAGER L. , VOGEL P.
Published: May 2016

The title compounds (II) and (VI) are prepared from (I) and (V) using procedure A); alternative methylenation methods fail to convert (I) to (II).
ChemInform Abstract: A Facile, Stereoselective Preparation of (Z)‐2,4‐Pentadienoates by Favorskii Rearrangement. Stereoselective Preparation of Methyl (Z)‐Cinnamates by Favorskii Rearrangement.
Authors: ENGLER T. A. , FALTER W.
Published: May 2016

The unsaturated ketones (I) are transformed into the tribromo derivatives (II) which react in situ with methylate to produce the isomeric esters (V) and (VI).
ChemInform Abstract: Synthesis of Allyl Sulfides via a Palladium Mediated Allylation.
Authors: TROST B. M. , SCANLAN T. S.
Published: May 2016

The carbonate (I) reacts with trimethylsilylethylmercaptide (II) in the presence of Pd‐catalysts to yield the thioester (III).
ChemInform Abstract: "Cross‐Coupling" of 2‐Chlorobenzothiazole with Benzothiazolylalkylmagnesium Bromide: Synthesis of Bis(2‐benzothiazolyl)alkanes.
Authors: BABUDRI F. , FLORIO S. , INGROSSO G. , TURCO A. M.
Published: May 2016

Die Benzothiazole (I) kuppeln mit Z‐Chlorbenzothiazol (II) in Gegenwart von Butylmagnesiumbromid zu den Bis‐benzothiazolylalkanen (III) bzw. zu Gemischen aus (III) und deren Tautomeren (IV).
ChemInform Abstract: Lithiation of 2‐Aminoquinoline Derivatives: Functionalization at the 3‐Position.
Authors: JACQUELIN J. M. , MARSAIS F. , GODARD A. , QUEGUINER G.
Published: May 2016

2‐Pivaloylaminoquinoline (I) is selectively lithiated in position 3 and then converted to numerous 3‐substituted quinolines (III) by adding various electrophiles.
ChemInform Abstract: Synthesis and Crystal Structure of 3‐Deoxy‐3‐fluoro‐1,2:5,6‐di‐O‐isopropylidene‐α‐D‐glucofuranose.
Authors: ARGENTINI M. , WEINREICH R. , OBERTI R. , UNGARETTI L.
Published: May 2016

The crystalline compound (III) is synthesized as shown in the reaction scheme.
Mechanistic Projection of First‐in‐Human Dose for Bispecific Immunomodulatory P‐Cadherin LP‐DART: An Integrated PK/PD Modeling Approach
Authors: Chen X , Haddish‐Berhane N , Moore P , Clark T , Yang Y , Li H , Xuan D , Barton HA , Betts AM , Barletta F
Published: May 2016

A bispecific immunomodulatory biotherapeutic molecule (P‐cadherin LP‐DART) based on the Dual Affinity Re‐Targeting (DART) scaffold has been developed as a potential antitumor treatment showing efficacy in preclinical testing. A minimal anticipated biological effect level (MABEL) approach was applied to project the first‐in‐human (FIH) dose, because of its immune agonistic properties following target engagement. The pharmacological activity of P‐cadherin LP‐DART is driven by binding to both P‐cadherin on the tumor cells and CD3 on T cells. Therefore, the concentration of the tri‐molecular synapse formed between drug, T cell, and tumor cell, rather than drug concentration, is responsible for efficacy. A mechanistic pharmacokinetic/pharmacodynamic (PK/PD)‐driven approach was explored to understand the exposure–response relationship based on the synapse concentration to project the MABEL dose. Orthogonal approaches including PK‐driven and receptor occupancy calculations were also investigated. This study showcases the application of PK/PD modeling in immune‐oncology, and could potentially be implemented for other bispecific biotherapeutics.