bluuebunny/crossref_metadata_2025 huggingface dataset:
Case Study on Agritourism Business Management: A New venture at Baramati District India
Authors: Et. al. Bimal Ekka,
Published: January 2024

Agritourism represents a significant form of strategy that supports rural communities and enhancing sustainable rural development. Over the years, technology has changed the nature of business transactions between the consumers and suppliers of goods and services. As within any other industry, changes driven by technology pose a major challenge in agritourism especially to farmers that do not have access to and knowledge about available technologies in agritourism. Agri-tourism is a business venture located on a working farm, ranch, or agricultural enterprise that provides an “experience” for visitors while generating supplemental income for the owner.

The study was conducted in Baramati District, of Maharashtra using a field survey and some group discussions with farmers and respective state officials of these districts. Results revealed that there are several possibilities for the establishment of agritourism in the country.
Organizational Behavior Of Organizational Behaviors (Ocb) Through Strengthening The Quality Of Work Life, Professional Commitment, And Personality
Authors: Et. al. Mikael Ajis,
Published: January 2024

Teachers' organizational citizenship behaviors is an important element related to the achievement of national education goals and the development of the Indonesian nation as a whole. The initial survey of Organizational citizenhip behaviors (OCB) for temporary teachers of private vocational high schools (SMK) in Sanggau District has not achieved maximum results. Therefore, it is interesting to study the civics behaviors of teachers' organizations. This study aims to determine efforts to improve teacher organizational citizenship behavior by examining the relationship between teacher organizational citizenship behavior and the variables of teacher work life quality, professional commitment and personality. This research uses correlational statistical methods and analysis with the systematic method is carried out. The unit of analysis of the research is non-permanent teachers of private vocational high schools (SMK) in Sanggau Regency, West Kalimantan province with a population of 176 and a sample of 123. The results showed that there was a positive relationship between the quality of work life (QWL) and the behavior of organizational citizens with the strength of the relationship ry1 = 0.98, there is a positive relationship between professional commitment and organizational citizen behaviors (OCB) with strength ry2 = 0.97, and there is a positive relationship between personality and OCB with strength ry3 = 0.861 so that organizational citizen behaviors (OCB) can be improved through quality of life work (QWL), professional commitment and teacher personality. Based on the results of the SITOREM analysis in this study, it can be explained that the priority order of improvements that need to be improved is: 1). Easy to socialize and authoritative, 2). Voluntary action, and; 3). Active in organization. As for the order that is maintained, namely: 1). Work outside the time of duty, 2). Dedication to work, 3). Empathy and avoid problems, 4). Liked, polite and happy to work together, 5). Reliable, 6). Responsible and convey constructive ideas, 7). Calm, focus and confident, 8). Integrity and commitment to career pursuits, 9). Interest in new things, 10). Responsibility for organizational regulations, 11). Professional development and social interaction, 12). Self evaluation and leadership, 13). Be proud of working and building relationships with fellow teachers, 14). Teaches and runs School administration. So it can be concluded that to improve the Organization citizenhip behaviors (OCB), teachers can pay attention to indicators that are not optimal for recommendations and determine the priority order of improvements that need to be made.
A Review Of Various Protection Schemes Of Power Transformers
Authors: Et. al. Vijay Kumar Sahu,
Published: January 2024

The power transformer is an electrical equipment that needs continuous monitoring and fast protection since it is very expensive and essential element for power system to perform effectively. Various methods for the protection are available. Most of the methods should be known for the protection of the transformer before practically protecting the same. Here a review is presented for various methods available for the protection of transformer. The most common protection technique used is the percentage differential logic, which provides discrimination between different operating conditions and internal fault. Some condition as, inrush current and CT saturation can cause mis-operation of differential protection. Few methods to solve this problem are also reviewed. Dissolved gas analysis (DGA) of power transformer is an investigative tool to monitor its health and to detect failures by recognizing anomalous patterns of DGA concentrations is also discussed. Some additional methods for transformer protection are also reviewed, as thermography method. Finally, a conclusion on different methods available for better performance is presented.
Eccentric Domination in Boolean Graph BG2(G) of a Graph G
Authors: Et. al. M. Bhanumathi,
Published: January 2024

Let G be a simple (p, q) graph with vertex set V(G) and edge set E(G). BG2(G) is a graph with vertex set V(G) È E(G) and two vertices are adjacent if and only if they correspond to two adjacent vertices of G, a vertex and an edge incident to it in G or two non-adjacent edges of G. In this paper, we studied eccentric domination number of Boolean graph BG2(G), obtained bounds of this parameter and determined its exact value for several classes of graphs.
Management Model of Hizbul Wathan Extracurricular Development in Muhammadiyah Senior High School
Authors: Et. al. Endang Listiowaty,
Published: January 2024

This study aims to determine the management development of Hizbul Wathan's extracurricular coaching model to improve Muhammadiyah students' competence in Indonesia. This qualitative research involved 6 participants who represented each data variable. Methods of data collection by observation, interviews, documentation. Data analysis used an interactive model from Milles and Huberman. The study results found that the Scout Movement of Hizbul Wathan has been carried out to manage Human Resources by involving administrators from the Central Quartir to the Branch Quartirs and coaches in Qabilah throughout Indonesia. Organisation and network management to lay a solid foundation for improving students' quality as Muslim is emphasised.
The Universality and Variation of Flower Metaphors for Love in English and Chinese Poems
Authors: Et. al. Didi Li,
Published: January 2024

Metaphor is ubiquitous in everyday life, not only in language but also in action and thought (Lakoff & Johnson, 1980). Difficult, intangible and abstract concept can be understood by applying metaphor. Emotion is viewed as a kind of abstract and private personal experience. Many of the metaphors have been studied by cognitive linguists over the past two decades, emotional metaphor is an important aspect of cognitive linguistics, and love has become one of the focuses of the researches. By applying the conceptual metaphor theory as a framework, this paper focuses on analyzing flower metaphors for love from the cross-cultural perspective based on figurative expressions in Chinese and English poems. The results of the study suggest that flower metaphors for love are likely to be near-universal at a general level in English and Chinese poems because of universal experiences, while cross-cultural variations and diversity exist in English and Chinese poems in culture-specific ways at a specific level in virtue of cognitive preferences.
Efficiency Of Individualization Of Education In Higher Educational Institutions.
Authors: Et. al. Galaev Qaxxor Karimovich,
Published: January 2024

This article focuses on improving the system of education for students studying in pedagogical higher education institutions. The research focuses on modern methods of individual education of students studying in the field of physical culture and its effectiveness.
Conjuctions And Punctuation As A Pragmatic Factor
Authors: Et. al. Ganieva Hayriniso Bakhtiyorovna,
Published: January 2024

This article explores the pragmatic meaning of conjunctions based on punctuation functions. It has been found that conjunctions produce locutive, illocutive, and perlocutive acts in speech.
Cluster-Module As Method Of The Improvement Of The Current Direction In Structure Of The Section Of The Physical Culture
Authors: Et. al. Taniberdiev A.A.,
Published: January 2024

The actuality of the research. Today in our country, special attention is paid to the development of physical culture and sports among students of higher educational institutions. The number of students studying in higher educational institutions of the Republic is increasing every year, and many of them are not ready to fully perform the loads of physical exercises set in the standard educational programs on the subject of "Physical culture and sports". This position requires the development of a new cluster-modular method aimed at improving the performance of students with different levels of physical development and physical fitness.
Planejamento estratégico nas empresas de energia solar: um estudo na cidade de Cianorte-PR
Authors: Pinto Danieli , Albanes Mayara Gabriele , Santos Carolaine Silva dos , Vilela Nágila Giovanna Silva
Published: January 2024

Empresas que prestam serviços de venda, instalação e manutenção de placas fotovoltaicas para geração de energia solar estão se expandindo no território nacional e, em especial, no estado do Paraná. Essas empresas, assim como outras dos mais diversos segmentos, podem utilizar o planejamento estratégico como uma ferramenta para estabelecimento e acompanhamento de objetivos que as mantêm competitivas no mercado. Em tal contexto, esta pesquisa tem o objetivo de analisar a percepção dos gestores em relação ao planejamento estratégico nas empresas de energia solar. Para atingir o objetivo foi realizada uma pesquisa qualitativa e descritiva. A coleta de dados se deu por meio de entrevistas semiestruturadas com os gestores de três empresas distintas, localizadas no município de Cianorte, estado do Paraná. Os dados foram analisados por meio da análise de conteúdo. Os resultados mostraram como é realizado o planejamento estratégico, quais as dificuldades no uso das ações estratégicas e a importância dessa ferramenta para a gestão organizacional.
É menino! É menina! Os riscos das tecnologias de análise facial para as identidades de gênero trans e não-binárias
Authors: Guedes Fernandes da Silva Paula
Published: January 2024

Nos últimos anos, houve rápido crescimento do desenvolvimento e uso de tecnologias de análise facial, como o reconhecimento facial, justificadas por razões ligada à aumento da segurança, ganhos de eficiência, prevenção de fraudes e oferecimento de melhores produtos e serviços. Porém, no atual estado da arte da tecnologia, sua implementação é potencialmente violadora de direitos humanos, principalmente para pessoas de identidades de gênero trans e não-binárias. O objetivo deste artigo é avaliar como a utilização de diferentes aplicações da tecnologia de reconhecimento facial impacta significativamente os direitos dessas pessoas, que já sofrem com marginalização da sociedade. Ao final, conclui-se que uma regulação multisetorial e multidisciplinar é imprescindível para garantir o desenvolvimento e uso de tecnologias que reforcem o exercício pleno de direitos fundamentais desses grupos, sem desconsiderar que alguns dos usos dessa ferramenta devem ser, desde logo, banidos em razão de sua incompatibilidade intrínseca com os direitos humanos, especialmente o direito à identidade e autodeterminação.Palavras-chave: inteligência artificial, reconhecimento facial, dado pessoal sensível, identidade de gênero trans e não-binárias, direitos humanos, regulação.Keywords: artificial intelligence, facial recognition, sensitive personal data, trans and non-binary gender identity, human rights, regulation.
O fundamento da responsabilidade kantiana: um instrumento contra a inefetividade dos direitos
Authors: Veloni Raphael Bruno , Lima Newton de Oliveira
Published: January 2024

Resumo: Neste trabalho, expõe-se a categoria dos deveres em sociedades qualificadas pelo risco de não concretização de direitos. O objetivo foi analisar a validade da reelaboração da lógica da responsabilidade civil com esteio na meritocracia e punição kantiana para a efetividade de direitos. A meritocracia é a prática de uma conduta que vai além do que se pode ser legalmente obrigado a realizar; logo, não representa tão somente uma conduta autorizada, mas também uma conduta estimulada pelo ordenamento, variando em certas interpretações. Dessa forma, a justificativa reside na elaboração de um sistema lógico para o mérito, débito e demérito das condutas humanas, para que os efeitos da responsabilidade civil tenham alcance geral, não se restringindo à reparação ou prevenção individual. No que tange à metodologia, nesta pesquisa de natureza qualitativa e de base bibliográfica, optou-se pelo método dedutivo. Os métodos de procedimento empregados foram o monográfico e histórico. Conclui-se pela validade, na responsabilidade civil, das sanções positivas no estímulo à realização dos deveres fundamentais pelos particulares, mas destaca a sua dependência do demérito. Nesses termos, demonstra-se certas balizas para esse insipiente sistema, sendo necessária vontade legislativa para construções mais abrangentes, as quais podem admitir as concepções de meritocracia desta pesquisa.Palavras-chave: responsabilidade kantiana, responsabilidade civil, lei jurídica, lei moral, imputação judiciária.Abstract: In this work, the category of duties in societies qualified for the risk of non-realization of rights is exposed. The objective was to analyze the validity of the reelaboration of the logic of civil liability based on Kantian notion of meritocracy and punishment for the effectiveness of rights. The meritocracy is the practice of a conduct that goes beyond what can be legally required to do; therefore, it not only represents an authorized conduct, but also a conduct stimulated by the order, varying in certain interpretations. Thus, the justification lies in the elaboration of a logical system for the merit, debit and demerit of human conducts, so that the effects of civil liability have general scope, not restricting itself to individual reparation or prevention. Regarding the methodology, in this qualitative research with a bibliographic basis, we opted for the deductive method. The methods of procedure employed were the monographic and historical one. It concludes by the validity, in civil liability, of the positive sanctions in stimulating the achievement of fundamental duties by individuals, but it highlights its dependence on demerit. In these terms, there are certain beacons for this incipient system, being necessary a legislative will for more comprehensive constructions, which may admit the meritocracy conceptions of this research.Keywords: Kantian responsibility, civil liability, legal law, moral law, judicial imputation.
El derecho a la salud de los afectados por enfermedades raras en un contexto de incertidumbre y avance tecnológico. La utilidad jurídica de la dignidad de la persona para mejorar su eficacia en Europa y España
Authors: Entrena Ruiz Daniel
Published: January 2024

El trabajo se centra en las enfermedades raras, en cuanto desafío para el Estado de Bienestar; una situación derivada de la incertidumbre científica que caracteriza este tipo de afecciones, que contribuye a intensificar las restricciones presupuestarias que, de por sí, presenta la respuesta estatal en materia sanitaria, pero que puede mejorar el avance tecnológico, concretamente gracias al big data. Con el objetivo de encontrar algún remedio jurídico, se indaga en el posible empleo de la dignidad humana, en cuanto fundamento de los derechos fundamentales y de toda la acción pública en la Sociedad; una opción que parece conceptualmente más clara en el ámbito interno español que en el europeo, dado el marco competencial aplicable en materia de salud pública y lo controvertido de la noción. Finalmente, se comprueba que el empleo de la noción, tampoco es plenamente respaldado por la jurisprudencia española.
Morphometric features of the human parotid salivary gland depending on the shape of the skull according to radiation research methods
Authors: Abduvosidov Khurshed A. , Chernyavskii Vladislav I. , Smirnova Alexandra D. , Belenkaya Olga I. , Vihareva Larisa V.
Published: January 2024

BACKGROUND: Intravital study of the parotid salivary gland individual characteristics using radiation research methods can be used by clinicians for more accurate diagnosis and planning of surgical treatment of the parotid salivary gland diseases.
AIM: Study of the parotid salivary glands’ morphometric parameters in people with different shapes of the facial and cerebral skull using radiation research methods.
MATERIAL AND METHODS: An analysis of the database of studies performed using magnetic resonance and computed tomography of 120 patients of different ages was carried out. Based on computed tomography data, cranial diameters were measured and cranial indices were calculated, according to which the studied material was divided into groups depending on the shape of the facial (leptena, mesena, eurienae) and cerebral (brachycranes, dolichocranes and mesocranes) parts of the skull. Based on magnetic resonance imaging data of the same patients, the morphometric parameters of the parotid salivary glands were analyzed in three planes. Groups were compared using the Kruskal–Wallis method, followed by pairwise comparisons using the Mann–Whitney method with the Bonferroni correction.
RESULTS: In the leptene group, the frontal size of the gland was statistically significantly smaller compared to similar sizes in the group of euriens (right p 0.0001, left p 0.0001) and mesenes (right p=0.0057, left p=0.012). The sagittal size of the gland was statistically significantly different between the brachy-, meso- and dolichocranial groups (p 0.0001 on the right and left). A significant tendency was revealed for a decrease in the sagittal size of the parotid salivary glands from 4.27 (3.77; 4.66) cm (right) and 4 (3.8; 4.6) cm (left) in dolichocraniform individuals to 3.57 (3.22; 3.86) cm (right) and 3.37 (3.16; 3.99) cm (left) in individuals with a brachiocranial skull shape. When measuring the frontal size in people with different skull shapes, a statistically significant difference in gland thickness between groups was found (p 0.0001 on the right and left).
CONCLUSION: In people with different forms of the facial skull, there is a difference in the vertical and frontal sizes of the parotid salivary glands, and with different forms of the brain skull, there is a difference in the sagittal and frontal sizes of the glands.
Shallow 3D Structure Investigation of Some Cities in the Guangdong–Hong Kong–Macao Greater Bay Area
Authors: Ye Xiuwei , Wang Liwei , Xiong Cheng , Wang Xiaona , Wen Genggeng , Yu Dayong , Guo Zhen , Wang Weitao , Lv Zuoyong , Wu Huaping , Zhang Yanxin
Published: January 2024

The Guangdong–Hong Kong–Macao Greater Bay Area (GBA), known as the fourth largest bay area in the world, is a world-class urban agglomeration located on the southeastern coast of China. Littoral fault zones that might trigger strong earthquakes are located offshore of the GBA, making it particularly crucial to pay attention to seismic disasters caused by the site-amplification effect of the strong earthquakes. Therefore, it is essential to determine the fine subsurface structure of the GBA urban agglomeration. In this study, we present the newly collected short-period dense array seismic data in the core urban area of the GBA, which covers a detection area of 60×60  km2 and consists of a backbone observation network and a basic observation network. The backbone observation network included 720 seismic stations spaced 2.25 km apart that recorded continuously for 30–35 days. The basic observation network has a total of 6214 seismic stations that were spaced 0.75 km apart and recorded continuously for 3–10 days. In addition, 63 excitation shots generated by methane detonation source were fired within the observation network. According to the preliminary analysis, the seismic stations recorded both clear active source signals and an abundance of passive source signals, indicating the high quality of the data. The high density of the seismic array and the high-quality seismic data provide important constraints for constructing the shallow fine crustal structure model and the 3D sedimentary thickness model.
Antecedentes histórico-legislativos de los dos tercios de legítima a favor de los hijos o descendientes del Código Civil español
Authors: Vázquez Lemos Ana
Published: January 2024

La importancia decisiva del sistema romano de sucesiones en la tradición histórico legislativa del Derecho sucesorio español es indiscutible. Las bases de nuestro Derecho en esta materia entroncan directamente con la tradición romana de la reserva de una porción de la herencia a favor del heredero, que podía ser un hijo o un extraño. Sin embargo, a lo largo del siglo XIX, el movimiento codificador que dio origen a la legislación vigente, decidió tomar otros derroteros rompiendo con una tradición que imperaba inalterable durante siglos. El motivo de esta ruptura con la tradición legislativa se ha querido buscar en la legislación medieval por eso es necesaria una labor de reinterpretación de las fuentes del Derecho como única forma adecuada de llegar a una conclusión acertada.
Arquitecturas Batientes
Authors: García-Louzao Araujo David
Published: January 2024

Un recorrido por los inicios de la industrialización productiva de los recursos naturales entorno a las dinámicas de conservación de alimento a través del patrimonio colectivo en el límite del mar.
La teoría de la evolución como marco para la comprensión de las enfermedades mentales
Authors: Santander Toro Jaime Andrés
Published: January 2024

¿Por qué considerar la teoría de la evolución en el marco comprensivo de la conducta humana y de las enfermedades mentales? Ante esta pregunta, el autor nos expone su visión de la influencia de dicha teoría en las enfermedades mentales, y en los problemas de conducta del ser humano.
Elementos de la literatura gótica en la película de Tim Burton Eduardo Manostijeras (1990)
Authors: Canido Muiño Elena
Published: January 2024

Eduardo Manostijeras (1990), del artista y cineasta Tim Burton, es una fábula moderna sobre un ser inacabado, incomprendido y rechazado por la sociedad que le rodea. Este artículo analiza tales conceptos así como cómo Burton, a través de simbolismo cinematográfico e  intertextualidad, reinterpreta asuntos clave y códigos propios de la tradición gótica en tan personal y aclamado film.
The Persistent Three: Combating Heart Disease, Cancer, and Stroke in North Carolina
Authors: Phelps Melanie , Smith Byrd Goldie , Mesa Ruben
Published: January 2024

Significant advances in science and medicine have not been adequate to dethrone heart disease, cancer, and stroke from their positions as three of the top killers of North Carolinians. In this issue, authors from across the state describe efforts to employ more holistic, comprehensive, and innovative approaches to primary and secondary prevention, as well as ensuring everyone who needs it has access to care and support through their disease journey. The articles in this issue include data and trends—as well as community examples—to explore evolving approaches to prevention, screening, treatment, and research.
DIGITAL ETIQUETTE IN BUSINESS COMMUNICATION: TYPICAL MISTAKES AND WAYS TO PREVENT THEM
Authors: Litvyakova Tatyana A. , Luneva Lyudmila P.
Published: January 2024

Digital technologies are gaining more and more popularity in a person's life and radically affect the communication process. It is necessary to create appropriate limits (norms and rules of etiquette behaviour) in the business communication. This article analyzes articles devoted to the culture of business communication in the digital environment, comprehends the personal experience of the authors, analyzes the results of a questionnaire of students of a technical university about digital etiquette, emphasizes the importance of forming a culture of business communication among students.
METHODOLOGY OF IMPROVING COMMUNICATIVE COMPETENCE STUDENTS’ OF THE MEDICAL UNIVERSITY (BASED ON THE TOPIC ‘STENOCARDIA’)
Authors: Koroleva Ilona A. , Slascheva Natalia I. , Fedotova Lubov A.
Published: January 2024

The most effective principles of the organization and intensification of the educational process on the subject of "Scientific style of speech" (Russian as a foreign language) are described. The development of a set of exercises of pre-text, pre-text and post-text exercises aimed at systematization and consolidation of knowledge, as well as the development of communication skills in a foreign language of future doctors (foreign medical students of the Faculty of Medicine 2-3 courses, topic "Angina pectoris", section "Patient Survey") is presented. Keywords: medical record, patient survey, role-playing game, communication, teaching method, methodology, specialty language, Russian as a foreign language.
Molecular-genetic and cytogenetic analyses of cotton chromosome introgression from Gossypium barbadense L. into the genome of G. hirsutum L. in BC2F1 hybrids
Authors: Sanamyan M. F. , Bobokhujayev Sh. U. , Abdukarimov Sh. S. , Silkova O. G.
Published: January 2024

Substitution lines of the cotton Gossypium hirsutum L. involving chromosomes of the tetraploid species G. bar ba dense L., G. tomentosum Nutt. ex Seem., and G. mustelinum Miers ex Watt. are a valuable source for breeding, increasing the genetic diversity of G. hirsutum. The substitution of certain G. hirsutum L. chromosomes with G. barbadense chromosomes affect fibre elongation, fibre yield, fibre strength, and micronaire. To increase the efficiency of creating lines, it is necessary to study the nature of the introgression of alien chromosomes into the G. hirsutum L. genome. As a result of molecular genetic analysis of BC2F1 hybrids obtained from crossing monosomic lines of the cotton G. hirsutum from the cytogenetic collection of Uzbekistan with monosomic backcross hybrids BC1F1 G. hirsutum × G. barbadense on the same chromosomes, genetic differences between the hybrids in the profile of chromosome-specific microsatellite SSR markers were found. The predominant introgression of chromosomes 4, 6 and 12 of the At-subgenome and 22 of the Dt-subgenome of G. barbadense was revealed, while chromosomes 2 and 7 of the At-subgenome and 18 of the Dt- subgenome of G. barbadense were characterized by elimination. Among them, chromosomes 7 of the At- sub genome and 18 of the Dt-subgenome of G. barbadense were eliminated in the first backcross generation. In this work, two lines, CS- B06 and CS-B07, from the American cytogenetic collection with a putative substitution involving chromosomes 6 and 7 of the At-subgenome were analysed. The presence of only polymorphic alleles from the species G. hirsutum and the absence of polymorphic alleles from the species G. barbadense were revealed, which showed the absence of substitution involving these chromosomes. BC2F1 hybrids with monosomy for both G. barbadense and G. hirsutum chromosomes were characterized by regular pairing of chromosomes and high meiotic indexes. However, many hybrids were characterized by a decrease in pollen fertility. Two hybrids with monosomy for chromosome 7 of the At-subgenome of G. hirsutum and chromosome 6 of the At-subgenome of G. barbadense had the greatest reduction in pollen viability (70.09 ± 1.57 and 75.00 ± 1.66 %, respectively). Thus, this work shows a specific feature in the introgression of individual chromosomes of the cotton species G. barbadense into the cotton G. hirsutum genome.
Inactivation of the TIM complex components leads to a decrease in the level of DNA import into Arabidopsis mitochondria
Authors: Tarasenko T. A. , Elizova K. D. , Tarasenko V. I. , Koulintchenko M. V. , Konstantinov Yu. M.
Published: January 2024

The phenomenon of DNA import into mitochondria has been shown for all major groups of eukaryotes. In plants and animals, DNA import seems to occur in different ways. It has been known that nucleic acids enter plant organelles through alternative channels, depending on the size of the imported molecules. Mitochondrial import of small DNA (up to 300 bp) partially overlaps with the mechanism of tRNA import, at least at the level of the outer membrane. It is noteworthy that, in plants, tRNA import involves components of the protein import apparatus, whose role in DNA transport has not yet been studied. In this work, we studied the role of individual components of the TIM inner membrane translocase in the process of DNA import into isolated Arabidopsis mitochondria and their possible association with the porin VDAC1. Using knockout mutants for the genes encoding Tim17 or Tim23 protein isoforms, we demonstrated for the first time the involvement of these proteins in the import of DNA fragments of different lengths. In addition, inhibition of transport channels with specific antibodies to VDAC1 led to a decrease in the level of DNA import into wild-type mitochondria, which made it possible to establish the specific involvement of this porin isoform in DNA import. In the tim17-1 knockout mutant, there was an additional decrease in the efficiency of DNA import in the presence of antibodies to VDAC1 compared to the wild type line. The results obtained indicate the involvement of the Tim17-1 and Tim23-2 proteins in the mechanism of DNA import into plant mitochondria. At the same time, Tim23-2 may be part of the channel formed with the participation of VDAC1, while Tim17-1, apparently, is involved in an alternative DNA import pathway independent of VDAC1. The identification of membrane carrier proteins involved in various DNA import pathways will make it possible to use the natural ability of mitochondria to import DNA as a convenient biotechnological tool for transforming the mitochondrial genome.
Chitosan and its derivatives as promising plant protection tools
Authors: Shcherban A. B.
Published: January 2024

In modern conditions, the increase in the yield of agricultural crops is provided not by expanding the areas of their cultivation, but mainly by introducing advanced technologies. The most effective strategy for this purpose is the development of genetically resistant and productive cultivars in combination with the use of a variety of plant protection products (PPPs). However, traditional, chemical PPPs, despite their effectiveness, have significant drawbacks, namely, pollution of environment, ecological damage, toxicity to humans. Recently, biological PPPs based on natural compounds have attracted more attention, since they do not have these disadvantages, but at the same time they can be no less effective. One of such agents is chitosan, a deacetylation product of chitin, one of the most common polysaccharides in nature. The high biological activity, biocompatibility, and safety of chitosan determine the breadth and effectiveness of its use in medicine, industry, and agrobiology. The review considers various mechanisms of action of chitosan as a biopesticide, including both a direct inhibitory effect on pathogens and the induction of plant internal defense systems as a result of chitosan binding to cell surface receptors. The effect of chitosan on the formation of resistance to the main classes of pathogens: fungi, bacteria, and viruses has been shown on a variety of plant objects. The review also discusses various ways of using chitosan: for the treatment of seeds, leaves, fruits, soil, as well as its specific biological effects corresponding to these ways. A separate chapter is devoted to protection products based on chitosan, obtained by its chemical modifications, or by means of combining of a certain molecular forms of chitosan with various substances that enhance its antipathogenic effect. The data presented in the review generally give an idea of chitosan and its derivatives as very effective and promising plant protection products and biostimulants.
Study of wheat (Triticum aestivum L.) breeding material potential for (Triticum aestivum L.)androgenesis
Authors: Petrash N. V. , Kapko T. N. , Sovetov V. V.
Published: January 2024

Doubled haploid technology is a valuable biotechnological approach in plant breeding that enables one to quickly create new varieties through the single-stage production of homozygous lines. The aim of this study was to assess the indicators of in vitro androgenesis in the anther culture of the initial breeding material of varieties and combinations of F1 and F2 and to identify promising accessions with good responsiveness. For that purpose, the plant material that proved promising for the breeding programs of Siberian Research Institute of Plant Production and Breeding (SibRIPP&B) was used. Ten cultivars of common wheat and the F1 and F2 hybrids of nine combinations were evaluated for the main parameters of in vitro androgenesis such as the number of new formations, albino, green and all regenerated plants. Induction of androgenesis in vitro was carried out in anther culture in growth medium Chu (N6) containing 1 mg/l of growth regulator 2,4-D. The studied samples showed different responses to induction. The maximum level of new formations was found in F2 hybrids Novosibirskaya 15 × Lutescens ShT-335. The largest number of green plants was found in F1 Novosibirskaya 15 × Lutescens ShT-335. According to the results of variance analysis, a significant ( p < 0.01) influence of genotype on the studied traits was established. Varieties with good responsiveness to anther culture (Novosibirskaya 15) and lack of responsiveness to in vitro androgenesis (Novosibirskaya 31) were identified. Novosibirskaya 16 was characterized by a low regeneration capacity of new formations. A significant heterotic effect was revealed considering the number of new formations per 100 anthers among the hybrids of such combinations as Novosibirskaya 15 × Lutescens ShT-335, Novosibirskaya 15 × Lutescens 111/09, and Zagora Novosibirskaya × Obskaya 2. Novosibirskaya 15 was recommended for inclusion in crossings as a parental form that provides high hybrid responsiveness during in vitro androgenesis. The use of doubled haploid technology made it possible to quickly create DH-lines based on the breeding material.
Reconstruction and analysis of the gene regulatory network for cell wall function in Arabidopsis thaliana L. leaves in response to water deficit
Authors: Volyanskaya A. R. , Antropova E. A. , Zubairova U. S. , Demenkov P. S. , Venzel A. S. , Orlov Y. L. , Makarova A. A. , Ivanisenko T. V. , Gorshkova T. A. , Aglyamova A. R. , Kolchanov N. A. , Chen M. , Ivanisenko V. A.
Published: January 2024

The plant cell wall represents the outer compartment of the plant cell, which provides a physical barrier and triggers signaling cascades under the influence of biotic and abiotic stressors. Drought is a factor that negatively affects both plant growth and development. Cell wall proteins (CWP) play an important role in the plant response to water deficit. The adaptation mechanisms of the cell wall to water loss are of interest for identifying important genetic factors determining plant drought resistance and provide valuable information on biomarkers for further selection aimed at increasing the yield of crop plants. Using ANDSystem, a gene network describing the regulation of CWPs under water restriction conditions was reconstructed. The analysis of the gene network and the transcriptome data analysis allowed prioritizing transcription factors (TF) based on their enrichment of differentially expressed genes regulated by them. As a result, scores were calculated, acting as indicators of the association of TFs with water deficit. On the basis of the score values, eight most significant TFs were selected. The highest priority was given to the TF GBF3. CWPs were prioritized according to the criterion of summing up the scores of transcription factors regulating these genes. Among the most prioritized CWPs were the AT5G03350 gene encoding a lectin-like protein, AT4G20860 encoding BBE-like 22 required for the oxidation of cellulose degradation products, and AT4G37800 encoding xyloglucan endotransglucosy lase/hydrolase 7. Overall, the implemented algorithm could be used for prediction of regulatory interactions between transcription factors and target genes encoding cell wall proteins in plants.
Bitcoin Narrative: A Consideration of the Development of an IC-PBL Course
Authors:   The Korean Society For Teaching English Literature, Yoon Seongho
Published: January 2024

This article critically examines the development process of the “Bitcoin Narrative” course, designed within the Industry-Coupled Project/Problem-Based Learning (IC-PBL) framework. It explores how humanities respond to the technological advancements of the Fourth Industrial Revolution. By shifting the perspective from a defensive stance to proactive engagement and practical application, the article highlights IC-PBL’s role in connecting humanities with the evolving technological landscape. The narrative of Bitcoin is used as a case study to investigate this intersection, delving into its philosophical, economic, and cultural origins. This approach also analyzes how Bitcoin’s development reflects broader trends in technology and society. The article addresses how Bitcoin’s initial anti-establishment ethos is gradually transforming towards institutionalization and regulatory acceptance. This shift underscores the evolving social context of technological innovations and the unpredictable nature of their impact on society. The “Bitcoin Narrative” course, as outlined in this article, aims to provide students with a critical understanding of Bitcoin’s influence on the humanities. It explores the ethical, social, and cultural dimensions of this digital currency. The course structure facilitates a comprehensive exploration of Bitcoin’s multifaceted implications, encouraging students to think critically about the intersection of technology and humanities.
Analysis of the Narrative Structure of The Curious Incident of the Dog in the Night-Time as a Meta-narrative
Authors:   The Korean Society For Teaching English Literature, Jeong Youn-Gil
Published: January 2024

This paper analyzes Mark Haddon’s The Curious Incident of the Dog in the Night-Time in relation to its meta-narrative qualities. This entails analyzing how the fusion of mystery elements and the autistic perspective enriches the novel’s thematic depth and narrative complexity, and how the narrative features inherent in Christopher’s perspective shape the novel’s structure and contribute to a proper understanding of the complex and varied autistic features. The paper demonstrates that Haddon’s method presents the overall narrative of the story as thoroughly factual, while at the same time metaphorizing the character of Christopher. In doing so, the paper emphasizes that Haddon’s portrayal of Christopher’s maturation is a meta-narrative in the way that a mystery or detective narrative is constructed and that Christopher, the narrator, is communicating with the reader by making himself the object of the narrative. In conclusion, the paper shows that Christopher’s search for the killer of his dog is a process that reveals the different layers of social disorder represented by his parents and neighbors. It will also argue that his role as a detective in this process can be seen as a narrative vehicle for revealing familial and social conflicts, as well as a signifier of the effects of these conflicts.
Rare Case of an Unresectable Giant Cell Tumor of Pubic Bone
Authors: Mittal Komal
Published: January 2024

Giant cell tumor (GCT) of bone, a benign but locally aggressive invasive tumor. It commonly affects long bones, has a low incidence in pelvis (1.5-6.1%). It is most commonly treated with a surgical approach. However, here we present a rare case of GCT of pubic bone, which was rendered unresectable due to its location and extensive nature. Thereby, treated with radical radiation therapy and injection denosumab.
Alkaloids and Flavonoids the Phyto Adjuvants in Cancer Therapy
Authors: K Babu
Published: January 2024

Cancer represents the second leading cause of deaths throughout the world. Though orthodoxic/ conventional cancer treatments such as chemotherapy, radiation and surgery assure the survival of cancer patients, they do not insure cure to life. They are often painful due to adverse side effects and also bring resistance to drugs and radiation. In recent years WHO Geneva cancer conference also proclaimed that regional herbal therapy can be given as adjuvants alongside chemotherapeutic agents since the former causes minimal side effects and are also safe to the normal cells and to the body. Herbal compounds being antioxidants and antimicrobial in nature and operate the apoptosis of cancer cells in-vivo through their innumerable mechanisms, they show greater potential as anti- cancer agents. Among the multitudes of herbal agents, the alkaloids and flavonoids proved as anti-proliferative, anti- angiogenic, anti-metastatic and anti-cancer adjuvants through cell line studies and in clinical therapy.
Obstructive Uropathy Caused by Uterine Prolapse
Authors: Shen Shu-Huei
Published: January 2024

An 84-year-old women presented with renal function impairment. The imaging studies showed uterine prolapse, causing bilateral hydronephrosis and hydroureter. In multiparous elder women with renal function impairment, obstructive uropathy caused by pelvic organ prolapse should be considered as an correctable etiology.
Evaluation of Nephrotoxicity using Lysoenzymuria in Patients with Rheumathoid Arthritis Treated with Most used Slow acting Antirheumatic Drugs-Saards and Establishment to the Diagnostic Value as Sifted Test
Authors: Spasovski Dejan
Published: January 2024

Aim: Aim of this research is to compare diagnostic values to the laboratory variable, to (appear) present quantitative works (evaluations) of diagnostic or sifted test with define to the sensitivity, the specification and the predictable value for positive and negative test and preciseness of the test , N-acetyl- β -D-glucosaminidase, (NAG), micro albumin, Rheumatoid factor (RF), C- reactive protein (CRP), DAS 28 index, at early found diagnosis, at not treated rheumatoid arthritis (RA). To determine whether changes in tubular enzymes excreted in urine depend on the disease evolution. Micro albuminuria is used as a marker for glomerular damage, and urine excretion of N-Acetyl- β -D- glucosaminidase (NAG) as indicator of proximal tubular damage.
Spermatic Cord Leiomyosarcoma: What is the Urologist’s Role?
Authors: Alae Touzani Mohammed
Published: January 2024

Introduction: Spermatic cord tumors always represented a challenge for urologists, given their rarity and, thus, the lack of guidelines concerning surgical treatment and oncological follow-up. Spermatic cord leiomyosarcome (SCL) is one of the rarest and most aggressive tumor type. It is characterized by a painless clinical presentation, with a slow growing para testicular mass, contrasting with very aggressive histological features. Surgery is the first step in the patient’s care, and it must follow several rules when a SCL is suspected.
Insulin Resistance in Hemodialysis Patients: How to Identify?
Authors: A Sh Rumyantsev
Published: January 2024

Insulin resistance is one of the common signs of end-stage renal failure. The onset of hemodialysis is accompanied by an increase in the sensitivity of peripheral tissues to insulin, but it does not eliminate insulin resistance. Clamp test in dialysis patients is difficult to apply. There is currently no consensus on how to replace it. It has been suggested that it is advisable to use a combination of HOMA-IR-1, HOMA2% B, Quantitative insulin sensitivity check index (QUICKI).
Clinical Efficacy of SelectMDx for the Detection of Clinically Significant Prostate Cancer
Authors: Lanzac A Pérez
Published: January 2024

Prostate Cancer (PCa) is the second most frequent cancer diagnosed in men. Elevated serum PSA levels (>4.0 ng/mL) detection is commonly used as a threshold for recommending the tissue biopsy. However, PSA serum levels are not adequate to correctly localize and stage PCa, and to determine its volume and aggressiveness. Therefore, there is a need for healthcare specialists to base the therapeutic decisions on new biomarkers and advanced imaging findings. SelectMDx is a novel non-invasive urine-based assay that measures the expression of two mRNA cancer-related biomarkers (HOXC6 and DLX1) combined with traditional clinical risk factors. Validation studies evidenced the higher precision of SelectMDx urine test to predict PCa. Combining the assay with multi-parametric magnetic resonance imaging (mpMRI) can improve PCa diagnosis and therefore the treatment. Compared to traditional diagnosis strategy, the use of the SelectMDx test in men with elevated PSA levels may lead to a reduction in overdiagnosis and overtreatment. SelectMDx has to be tested in larger and heterogeneous populations in diverse clinical settings to further assess its clinical validity and utility.
El cine samurái como subgénero cinematográfico: La influencia de Akira Kurosawa
Authors: Dávila Danny , Lino Valeria , Maticorena Ximena , Seminario Gianella
Published: January 2024

El mito del samurái se caracteriza por el uso de la violencia —donde se hace uso de la katana como arma principal—, además de la apariencia extravagante y el seguimiento de un estricto código moral. Estos personajes se distinguen por siempre seguir las órdenes de un amo. Sin embargo, dentro de las películas de Akira Kurosawa se nos presenta al samurái como un antihéroe que sigue sus objetivos basándose en sus propios códigos morales y yendo en contra del camino samurái convencional. Todos estos elementos, planteados por Kurosawa, se reflejan en algunas películas de los directores Takashi Miike y Takeshi Kitano, que determinan la construcción del subgénero samurái en el mundo cinematográfico actual.
VALIDITAS DAN KEPRAKTISAN BUKU ILMIAH POPULER LIMBAH AIR KELAPA TUA SEBAGAI ZPT ALAMI PERTUMBUHAN SAWI (Brassica juncea L.)
Authors: Al Banna Nida Zahra , Ilmiyah Najimatul , Khairunnisa Khairunnisa
Published: January 2024

Popular scientific books are included in the learning resources. Popular scientific books are types of knowledge books whose discussion is based on research results. This book has a simple, short, and clear language arrangement to make it easier for all people to understand. This study aims to describe the validity and practicality of popular scientific books of old coconut water waste as a natural growth regulator for mustard green (Brassica juncea L.) growth. This research uses the type of EDR (Educational Design Research) research with Tessmer's formative evaluation design which is limited in several stages, namely self-evaluation, expert review, and one-to-one evaluation. This study used validity and practicality instruments. The results showed that the validity of popular scientific books was declared very valid with a value of 85.80%. Meanwhile, for the practicality of popular scientific books, it obtained a score of 88.33% with an excellent category.