bluuebunny/crossref_metadata_2025 huggingface dataset:
Head in the clouds, feet on the ground: how transdisciplinary learning can foster transformative change—insights from a summer school
Authors: Atienza Casas Sara , Calicis Camille , Candiago Sebastian , Dendoncker Nicolas , Desair Jomme , Fickel Thomas , Finne Eirik Aasmo , Frison Christine , Haensel Maria , Hinsch Malte , Kulfan Tyler , Kumagai Joy A. , Mialyk Oleksandr , Nawrath Maximilian , Nevzati Fiona , Washbourne Carla , Wübbelmann Thea
Published: May 2023

There is a pressing need for transformative change, with a vision of long-term human well-being within planetary boundaries. The lack of progress—despite increasing awareness and action—illustrates how challenging it is to foster change in our complex global society. Education and learning are needed to enable change. Transdisciplinary learning, which meaningfully integrates diverse knowledge and perspectives, contributes to developing an integrative understanding—a necessity for tackling complex challenges. We explore how transdisciplinary learning for early-career researchers can foster transformative change and lead to increased biodiversity conservation. This paper focuses on a case study of the authors’ shared experiences during the 2021 Alternet Summer School, which focused on transformative change for biodiversity conservation and human well-being. In this introspective research, we gained insights through an online survey for participants and organizers of the summer school (n = 27). Using qualitative content analysis, we identify seven crucial elements of transdisciplinary learning which can lead to transformative change on (a) a personal level, as the learning process shifts values and helps researchers identify their roles; (b) a research level, by rethinking science and providing tools for transdisciplinary approaches, and (c) a societal level, by moving from the individual to the collective and constructing a shared vision for a sustainable future. Participants highlighted how changes on all these levels could benefit biodiversity conservation. These insights point to the benefit of transdisciplinary learning opportunities that empower young researchers to take up their part in fostering transformative change.
Neural Substrates for Hand and Shoulder Movement in Healthy Adults: A Functional near Infrared Spectroscopy Study
Authors: Bonnal Julien , Ozsancak Canan , Monnet Fanny , Valery Antoine , Prieur Fabrice , Auzou Pascal
Published: May 2023

Characterization of cortical activation patterns during movements in healthy adults may help our understanding of how the injured brain works. Upper limb motor tasks are commonly used to assess impaired motor function and to predict recovery in individuals with neurological disorders such as stroke. This study aimed to explore cortical activation patterns associated with movements of the hand and shoulder using functional near-infrared spectroscopy (fNIRS) and to demonstrate the potential of this technology to distinguish cerebral activation between distal and proximal movements. Twenty healthy, right-handed participants were recruited. Two 10-s motor tasks (right-hand opening-closing and right shoulder abduction-adduction) were performed in a sitting position at a rate of 0.5 Hz in a block paradigm. We measured the variations in oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR) concentrations. fNIRS was performed with a 24-channel system (Brite 24®; Artinis) that covered most motor control brain regions bilaterally. Activation was mostly contralateral for both hand and shoulder movements. Activation was more lateral for hand movements and more medial for shoulder movements, as predicted by the classical homunculus representation. Both HbO2 and HbR concentrations varied with the activity. Our results showed that fNIRS can distinguish patterns of cortical activity in upper limb movements under ecological conditions. These results suggest that fNIRS can be used to measure spontaneous motor recovery and rehabilitation-induced recovery after brain injury. The trial was restropectively registered on January 20, 2023: NCT05691777 (clinicaltrial.gov).
Targeting PELP1 oncogenic signaling in TNBC with the small molecule inhibitor SMIP34
Authors: Altwegg Kristin A. , Pratap Uday P. , Liu Zexuan , Liu Junhao , Sanchez John R. , Yang Xue , Ebrahimi Behnam , Panneerdoss Durga Meenakshi , Li Xiaonan , Sareddy Gangadhara R. , Viswanadhapalli Suryavathi , Rao Manjeet K. , Vadlamudi Ratna K.
Published: May 2023

Purpose

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Oncogenic PELP1 is frequently overexpressed in TNBC, and it has been demonstrated that PELP1 signaling is essential for TNBC progression. The therapeutic utility of targeting PELP1 in TNBC, however, remains unknown. In this study, we investigated the effectiveness of SMIP34, a recently developed PELP1 inhibitor for the treatment of TNBC.

Methods

To ascertain the impact of SMIP34 treatment, we used seven different TNBC models for testing cell viability, colony formation, invasion, apoptosis, and cell cycle analysis. Western blotting and RT-qPCR were used to determine the mechanistic insights of SMIP34 action. Using xenograft and PDX tumors, the ability of SMIP34 in suppressing proliferation was examined both ex vivo and in vivo.

Results

TNBC cells’ viability, colony formation, and invasiveness were all decreased by SMIP34 in in vitro cell-based assays, while apoptosis was increased. SMIP34 treatment promoted the degradation of PELP1 through the proteasome pathway. RT-qPCR analyses confirmed that SMIP34 treatment downregulated PELP1 target genes. Further, SMIP34 treatment substantially downregulated PELP1 mediated extranuclear signaling including ERK, mTOR, S6 and 4EBP1. Mechanistic studies confirmed downregulation of PELP1 mediated ribosomal biogenesis functions including downregulation of cMyc and Rix complex proteins LAS1L, TEX-10, and SENP3. The proliferation of TNBC tumor tissues was decreased in explant experiments by SMIP34. Additionally, SMIP34 treatment markedly decreased tumor progression in both TNBC xenograft and PDX models.

Conclusions

Together, these findings from in vitro, ex vivo, and in vivo models show that SMIP34 may be a useful therapeutic agent for inhibiting PELP1 signaling in TNBC.
A prospective cohort study of clinical characteristics and outcomes in Chinese patients with estrogen receptor-negative/progesterone receptor-positive early breast cancer
Authors: Fan Yu , Zhong Xiaorong , Wang Yu , Wang Zhu , Luo Ting , Wang Yanping , Zheng Hong
Published: May 2023

Purpose

This study aimed to examine the clinical characteristics and outcomes of patients with estrogen receptor-negative (ER−)/progesterone receptor-positive (PR+) early breast cancer. We also aimed to investigate the benefits of adjuvant endocrine therapy (ET) in this patient population.

Methods

Patients with early breast cancer diagnosed at West China Hospital were divided into the ER−/PR+, ER+, and ER−/PR− groups. The chi-square test was used to analyze differences in clinical and pathological features among the groups. Multivariable Cox and Fine–Gray regression models were used to compare mortality and locoregional recurrence (LRR)/distant recurrence (DR), respectively. We performed a subgroup analysis to determine which ER−/PR+ patients can benefit more from ET.

Results

From 2008 to 2020, we enrolled 443, 7104, and 2892 patients into the ER−/PR+, ER+, and ER−/PR− groups, respectively. The ER−/PR+ group showed more unfavorable clinical features and aggressive pathological characteristics than the ER+ group. The mortality, LRR, and DR rates were higher in the ER−/PR+ than in the ER+ group. Most clinical features and pathological characteristics were similar between the ER−/PR+ and ER−/PR− group and their outcomes were comparable. In the ER−/PR+ group, patients who received ET showed significantly lower LRR and mortality rates than those who did not; however, no difference was observed in DR. Subgroup analysis suggested that ER−/PR+ patients age ≥ 55 years, and postmenopausal status can benefit from ET.

Conclusion

ER−/PR+ tumors have more aggressive pathological characteristics and more unfavorable clinical features than ER+ tumors. ET can reduce the LRR and mortality rates in ER−/PR+ patients. Postmenopausal and age ≥ 55 years ER−/PR+ patients can benefit from ET.
Selling visibility-boosts on dating apps: a problematic practice?
Authors: de Vries Bouke
Published: May 2023

Love, sex, and physical intimacy are some of the most desired goods in life and they are increasingly being sought on dating apps such as Tinder, Bumble, and Badoo. For those who want a leg up in the chase for other people’s attention, almost all of these apps now offer the option of paying a fee to boost one’s visibility for a certain amount of time, which may range from 30 min to a few hours. In this article, I argue that there are strong moral grounds and, in countries with laws against unconscionable contracts, legal ones for thinking that the sale of such visibility boosts should be regulated, if not banned altogether. To do so, I raise two objections against their unfettered sale, namely that it exploits the impaired autonomy of certain users and that it creates socio-economic injustices.
Selective Localization of Nanoparticles to Enhance the Properties of PBS/PLA Nanocomposite Blown Films
Authors: Garofalo Emilia , Di Maio Luciano , Scarfato Paola , Russo Paola , Incarnato Loredana
Published: May 2023

The addition of nanoparticles could allow to upgrade the performances of biopolymers, making them fit to replace petroleum-based plastics. In order to maximize the sustainability benefits of bio-nanocomposites, it is fundamental to opportunely tune their bulk properties by acting on their nanostructure. In particular, in nanocomposite blends the final morphologies are highly dependent on the selective localization of the nanoparticles: mainly inside one of the polymeric phases and/or at the interface.

In this work, nanocomposite PBS (polybutylene succinate)/PLA (polylactic acid) blown films were prepared with the aim of optimizing their mechanical and gas barrier properties by profiting from the multiple functions of nanofillers as reinforcements, compatibilizers and morphology-directors. PBS/PLA blends, at a constant polymers’ weight proportion (80/20), were prepared by twin-screw extrusion, adding a constant amount of a lamellar nanosilicate (Cloisite 30B), according to different mixing routes: (i) by first dispersing the nanofillers inside the PLA or PBS phase, followed by the compounding with the other resin; (ii) by direct mixing of all the three components.

The nanocomposite systems showed a finer dispersion of the PLA phase compared to the neat PBS/PLA blend. While a good exfoliation degree of the nanosilicate was generally observed for all the hybrid samples, the different blending sequence of the nanofillers significantly affected their preferential localization. In particular, the barrier and mechanical performances of the hybrid film PBS/(PLA + C30B) were most positively affected by the selective localization of the nanoplatelets at PBS/PLA interface, since their compatibilizing action was effectively exploited. In fact, this latter sample exhibited an interesting increase (+ 29%) of the deformation at break and a significant improvement (+ 33%) of the oxygen barrier compared with the neat PBS/PLA blend.
A Call for Rethinking International Arbitration: A TWAIL Perspective on Transnationality and Epistemic Community
Authors: Vesali Mahmoud Mansour , Sheikhattar Hosna
Published: May 2023

Despite the increasingly diversified discourses in international commercial arbitration, this device of socio-legal regulation remains a relatively under-theorized subject. In particular, far too little attention has been paid to analyzing international commercial arbitration through critical approaches such as Third World Approaches to International Law (TWAIL). TWAIL is broadly understood as a methodological reorientation in international law by highlighting the historical links between the foundations of this field of law and the history of capitalism and imperialism as well as the colonial and Eurocentric legacies in the structure and operation of the current international legal regime. With this in mind, two fronts in international commercial arbitration invite a reexamination through a TWAIL perspective and by drawing on the concept of hegemony. One front is the transnational account of arbitration, and the other one is the epistemic community of arbitration. By examining these two notions through a narrative of hegemony of Western legal traditions, we posit that any effective attempt at redefining or reforming arbitral governance structure towards sustaining diversity requires a deeper understanding of historical and current world power structures and creating a vision for the prospect of dehegemonization.
Individualised prescription of medications for treatment of obesity in adults
Authors: Hocking Samantha , Sumithran Priya
Published: May 2023

Obesity continues to increase in prevalence globally, driven by changes in environmental factors which have accelerated the development of obesity in individuals with an underlying predisposition to weight gain. The adverse health effects and increased risk for chronic disease associated with obesity are ameliorated by weight loss, with greater benefits from larger amounts of weight reduction. Obesity is a heterogeneous condition, with the drivers, phenotype and complications differing substantially between individuals. This raises the question of whether treatments for obesity, specifically pharmacotherapy, can be targeted based on individual characteristics. This review examines the rationale and the clinical data evaluating this strategy in adults. Individualised prescribing of obesity medication has been successful in rare cases of monogenic obesity where medications have been developed to target dysfunctions in leptin/melanocortin signalling pathways but has been unsuccessful in polygenic obesity due to a lack of understanding of how the gene variants associated with body mass index affect phenotype. At present, the only factor consistently associated with longer-term efficacy of obesity pharmacotherapy is early weight loss outcome, which cannot inform choice of therapy at the time of medication initiation. The concept of matching a therapy for obesity to the characteristics of the individual is appealing but as yet unproven in randomised clinical trials. With increasing technology allowing deeper phenotyping of individuals, increased sophistication in the analysis of big data and the emergence of new treatments, it is possible that precision medicine for obesity will eventuate. For now, a personalised approach that takes into account the person’s context, preferences, comorbidities and contraindications is recommended.
Systematic reappraisal of marsh-orchids native to Scotland
Authors: Bateman Richard M. , Denholm Ian , McLeod Lindsey , Craig William , Ennos Richard A.
Published: May 2023

The intensively studied Eurasian orchid genus Dactylorhiza has become a model system for exploring allopolyploid evolution, yet determining the optimal circumscriptions of, and most appropriate ranks for, its constituent taxa remain highly controversial topics. Here, novel allozyme data and detailed morphometric data for 16 Scottish marsh-orchid populations are interpreted in the context of recent DNA sequencing studies. Despite being derived from the same pair of parental species, the two allopolyploid species that currently occur in Scotland can reliably be distinguished using allozymes, haplotypes, ribotypes or sequences of nuclear genes. A modest range of diverse morphological characters are shown to distinguish the two molecularly-circumscribed species, but they have in the past been obscured by equivalent levels of infraspecific variation in characters rooted in anthocyanin pigments; these characters are better employed for distinguishing infraspecific taxa. Dactylorhiza francis-drucei (formerly D. traunsteinerioides) is confirmed as being distinct from the continental D. traunsteineri/lapponica, probably originating through allopatric isolation once the continental lineage reached Britain. All Scottish populations are attributed to the comparatively small-flowered, anthocyanin-rich subsp. francis-drucei, which includes as a variety the former D. 'ebudensis'; the less anthocyanin-rich subsp. traunsteinerioides is confined to Ireland, North Wales and northern England. In contrast with D. francis-drucei, only a minority of Scottish populations of D. purpurella are attributed to the anthocyanin-rich race, var. cambrensis. This species most likely originated through an allopolyploidy event that occurred comparatively recently within the British Isles, as it contains allozyme alleles distinctive of British rather than continental D. incarnata (its diploid pollen-parent). In contrast, the rare Scottish population of D. incarnata subsp. cruenta shares with its Irish counterparts a continental genotype, and is most likely a recent arrival in Scotland through long-distance dispersal. Among all European allotetraploid dactylorchids, D. purpurella is the species that most closely resembles D. incarnata, both molecularly and morphologically.
KLF11 is an independent negative prognostic factor for breast cancer from a cohort study and induces proliferation and inhibits apoptosis in vitro
Authors: Lin Lili , Pfender Kristina , Ditsch Nina , Kuhn Christina , Rahmeh Martina , Peng Lin , Schmoeckel Elisa , Mayr Doris , Trillsch Fabian , Mahner Sven , Kessler Mirjana , Jeschke Udo , Hester Anna
Published: May 2023

Background

The therapy concepts that target several members of krüppel like factor (KLF) family have been achieved in breast cancer (BC). However, the role of KLF11 in BC remains unclear. This study explored the prognostic significance of KLF11 in BC patients and investigated its functional roles in this malignancy.

Methods

Immunohistochemistry (IHC) staining of KLF11 in 298 patients’ samples was performed to determine the prognostic role of the KLF11. Then the protein level was correlated to clinicopathological characteristics and survival outcomes. Afterward, the function of KLF11 was explored in vitro with siRNA-mediated loss-of-function of cell viability, proliferation, and apoptosis.

Results

From the cohort study, we found that the expression of KLF11 was positively associated with highly proliferative BC of BC. Furthermore, prognostic analysis demonstrated that KLF11 was an independent negative factor for disease-free survival (DFS) and distant-metastasis-free survival (DMFS) of BC. The KLF11-related prognostic model for DFS and DMFS showed high accuracy in predicting the 3-,5- and 10 -year survival probability of BC patients. Additionally, the knockdown of KLF11 inhibited cell viability and proliferation, as well as induced cell apoptosis in MCF7 and MDA-MB-231 cells, while only inhibited cell viability and induced cell apoptosis in SK-BR-3 cells.

Conclusions

Our study indicated that targeting KLF11 is an interesting therapeutic concept and further research could lead to a new therapeutic improvement in BC, especially in highly aggressive molecular subtypes.
Capital Controls and International Economic Law
Authors: Mercurio Bryan
Published: May 2023

Focusing on capital controls, this study provides rigorous legal analysis to establish whether the mandate of the International Monetary Fund (IMF) extends to the capital account; that is, whether the IMF has the authority to control and/or regulate the use of capital controls by its member states. The book then analyses whether a country's use of capital controls is consistent with the obligations and commitments undertaken in various multilateral and bilateral trade and investment agreements. Finally, it analyses the tension within international economic law, as the IMF now encourages the use of capital controls under certain circumstances, while most trade/investment agreements prohibit or limit their use. Proposing a way forward to alleviate the tension and construct a more harmonious relationship between the norms and standards of finance, trade and investment, this study will be essential reading for policymakers.
Behavioural Incentive Design for Health Policy
Authors: Costa-Font Joan , Hockley Tony , Rudisill Caroline
Published: May 2023

Behavioural economics has become a popular way of tackling a broad range of issues in public policy. By presenting a more descriptive and possibly accurate representation of human behaviour than traditional economics, Behavioural Incentive Design for Health Policy tries to make sense of decisions that follow a wider conception of welfare, influenced by social norms and narratives, pro-social motivations and choice architectures which were generally neglected by standard economics. The authors show how this model can be applied to tackle a wide range of issues in public health, including smoking, the obesity crisis, exercise uptake, alcoholism, preventive screenings and attitudes towards vaccinations. It shows not only how behavioural economics allows us to better understand such challenges, but also how it can design effective incentives for addressing them. This book is an extensive reassessment of the interaction between behavioural incentives and health.
Understanding the Christianity–Evolution Relationship
Authors: Ruse Michael
Published: May 2023

The relationship between science and religion is a topic that runs rife with misconceptions, misunderstandings and debates. Are science and religion always in conflict? Is Darwin's theory of evolution through natural selection atheistic? How does history shape current debates around science and religion? This book explores these questions in a neutral and balanced way, focusing on the Christianity-evolution relationship. It shows that two paradigms – the world as an organism and the world as a machine – have critically informed and guided the discussions. The author uses his deep understanding of the history and philosophy of science, particularly Darwinian evolutionary theory and its controversies through the past 150 years, to bring fresh ideas to the debate and to wider discussions such as environmental issues and hate. Understanding the Christianity-Evolution Relationship provides a lively and informative analysis and lays out multiple views so that readers can make their own judgements to increase their understanding.
North Korea, Tricontinentalism, and the Latin American Revolution, 1959–1970
Authors: Taylor Moe
Published: May 2023

In this deftly argued book, Moe Taylor examines the flourishing relationship between North Korea, Cuba, and the Latin American Left through the 1960s. Beginning with the Cuban Revolution, which represented North Korea's first phase of major engagement with the region, both nations found common ground in the belief that the hopes of the international Left relied on an anti-imperialist, anti-US united front – a global campaign of guerrilla warfare against US power. This special partnership included a joint-program to train, arm, and finance revolutionary movements throughout Latin America. In the process, North Korea became an important influence on Cuban and Latin American left-wing discourse on matters of economic development, revolutionary organization and strategy, democracy, and leadership. Both nations pioneered a new Third World-ist political phenomenon – Tricontinentalism – that challenged Soviet and Chinese leadership over the international communist movement, and injected a fiercely radical current into the left-wing and anti-colonial movements of the Global South.
DIOPHANTINE EQUATIONS OF THE FORM OVER FUNCTION FIELDS
Authors: RAY ANWESH
Published: May 2023

Let
$\ell $
and p be (not necessarily distinct) prime numbers and F be a global function field of characteristic
$\ell $
with field of constants
$\kappa $
. Assume that there exists a prime
$P_\infty $
of F which has degree
$1$
and let
$\mathcal {O}_F$
be the subring of F consisting of functions with no poles away from
$P_\infty $
. Let
$f(X)$
be a polynomial in X with coefficients in
$\kappa $
. We study solutions to Diophantine equations of the form
$Y^{n}=f(X)$
which lie in
$\mathcal {O}_F$
and, in particular, show that if m and
$f(X)$
satisfy additional conditions, then there are no nonconstant solutions. The results apply to the study of solutions to
$Y^{n}=f(X)$
in certain rings of integers in
$\mathbb {Z}_{p}$
-extensions of F known as constant
$\mathbb {Z}_p$
-extensions. We prove similar results for solutions in the polynomial ring
$K[T_1, \ldots , T_r]$
, where K is any field of characteristic
$\ell $
, showing that the only solutions must lie in K. We apply our methods to study solutions of Diophantine equations of the form
$Y^n=\sum _{i=1}^d (X+ir)^m$
, where
$m,n, d\geq 2$
are integers.
The Country They Built: Dynamic and Complex Indigenous Economies in North America before 1492
Authors: Carlos Ann M.
Published: May 2023

The economic history of the United States is that of Europeans and their institutions. Indigenous nations are absent. This absence is partly due to a lack of data but perhaps also to a perception that Indigenous communities contributed little to U.S. growth. Three case studies explore the economic complexity and social stratification across different nations/regions prior to contact. Migrants to the United States came not to an empty land but one with settled agriculture, complex production processes, and extensive trade relations, upon which Europeans built.
Global gyrokinetic simulations of electromagnetic turbulence in stellarator plasmas
Authors: Mishchenko Alexey , Borchardt Matthias , Hatzky Roman , Kleiber Ralf , Könies Axel , Nührenberg Carolin , Xanthopoulos Pavlos , Roberg-Clark Gareth , Plunk Gabriel G.
Published: May 2023

Global electromagnetic turbulence is simulated in stellarator geometry using the gyrokinetic particle-in-cell code EUTERPE. The evolution of the turbulent electromagnetic field and the plasma profiles is considered at different values of the plasma beta and for different magnetic configurations. It is found that turbulence is linearly driven at relatively high toroidal mode numbers. In the nonlinear regime, lower toroidal mode numbers, including zonal flows, are excited resulting in a quench of the linear instability drive. The turbulent heat flux is outward and leads to the nonlinear relaxation of the plasma temperature profile. The particle flux is inward for the parameters considered. The effect of the parallel perturbation of the magnetic field on the stellarator turbulence is addressed.
How to Change Your Mind: The Contemplative Practices of Philosophy
Authors: Kalmanson Leah
Published: May 2023

The methods of philosophy may be associated with practices such as rational dialogue, logical analysis, argumentation, and intellectual inquiry. However, many philosophical traditions in Asia, as well as in the ancient Greek world, consider an array of embodied contemplative practices as central to the work of philosophy and as philosophical methods in themselves. Here we will survey a few such practices, including those of the ancient Greeks as well as examples from East Asian traditions. Revisiting the contemplative practices of philosophy can help us to rethink the boundaries of the discipline, the nature and scope of scholarly methods, and the role of philosophy in everyday life.
Grammars of Listening: Or On the Difficulty of Rendering Trauma Audible
Authors: Acosta López María del Rosario
Published: May 2023

What would it mean to do justice to testimonies of traumatic experience? That is, how can experiences which do not fit the customary scripts of sense-making be heard? Whereas processes of official memorialization or legal redress often demand that victims and survivors convey their experiences through familiar modes of narration, in my project on ‘grammars of listening’ or ‘gramáticas de lo inaudito’ I want to ask how it might be possible to hear these experiences on their own terms and what the challenges are that we encounter when trying to do so. What I ultimately want to argue is that doing justice to trauma requires a profound philosophical questioning of the conditions that allow us to listen to testimony, and a true reckoning of the responsibility that we bear as listeners.
Fernando Pessoa: The Poet as Philosopher
Authors: Ganeri Jonardon
Published: May 2023

Fernando Pessoa (1888–1935) lived what was in many ways an astonishingly modern, transcultural, and translingual life. He was born in Lisbon, the point of departure for Vasco da Gama's voyage to India as commemorated by Pessoa's forebear, the poet Luís de Camões. Pessoa grew up in Anglophone Durban, acquiring a lifelong love for English poetry and language. Returning to Lisbon, from where he would never again leave, he set himself the goal of travelling throughout an infinitude of inner landscapes, to be an explorer of inner worlds. He published very little, but left behind a famous trunk containing a treasure trove of scraps, on which were written some of the greatest literary works of the twentieth century, mainly in Portuguese but also a substantial amount in English and French. Pessoa is now acknowledged as one of the greatest poets of the twentieth century, and he has emerged over the last decade as a forgotten voice in twentieth-century modernism, taking his rightful place alongside C.P. Cavafy, Franz Kafka, T.S. Eliot, James Joyce, and Jorge Luis Borges. Pessoa was also a serious student of philosophy and himself a very creative philosopher, yet his genius as a philosopher has as yet hardly been recognized at all.
In the Mood: Why Vibes Matter in Reading and Writing Philosophy
Authors: De Cruz Helen
Published: May 2023

Philosophers often write in a particular mood; their work is playful, strident, strenuous, or nostalgic. On the face of it, these moods contribute little to a philosophical argument and are merely incidental. However, I will argue that the cognitive science of moods and emotions offers us reasons to suspect that mood is relevant for philosophical texts. I use examples from Friedrich Nietzsche and Rudolph Carnap to illustrate the role moods play in their arguments. As readers and writers of philosophical texts, we do well to attend to mood.
Japanese Philosophers on Plato's Ideas
Authors: Notomi Noburu
Published: May 2023

Although Plato studies occupy an important place in academia, the empiricist stance in considering reality, the modern epistemology of the self-identical ego, the devaluation of the image and imagination, and the restrictions on philosophy within academic research sometimes cause us to lose sight of the essence of Plato's texts and thought when analysing them. Discussing Plato from a Japanese perspective, this paper will introduce three Japanese thinkers, Sakabe Megumi, Izutsu Toshihiko, and Ino-ue Tadashi, who have critically examined modern Western philosophy from their own philosophical backgrounds and provided valuable suggestions. Taking into account the arguments of these Japanese thinkers, this paper emphasizes the notions of separation, purification, and transcendence as core concepts of Plato's philosophy.
From Hosting Words to Hosting Civilizations: Towards a Theory of ‘Guardianship’ and ‘Deep Hospitality’
Authors: Albertini Tamara
Published: May 2023

In this paper, I cover some ideas first developed during a research year that took me, among other countries, to Bulgaria, where I enjoyed a Fulbright scholarship in 2018–2019. At a conference in Plovdiv (ancient Philippopolis), I gave a talk entitled ‘Neither Clash Nor Dialogue: We Are Each Other's Guardians’.2 A journalist in the audience became irritated and asked me, ‘What do you mean by “neither/nor”? What else is there?’ I answered that the explanation was in the subtitle ‘We Are Each Other's Guardians’. It proposes a third course, one resting on the notion of ‘guardianship’ – as a moral obligation. In what follows, I elaborate further on this concept by relating it to the notion of hospitality, not the Derridian variant, but one that is conceptualized as a transformative event for both the host and the guest, which is why I call it ‘deep hospitality’.
Advantages of visiting your home country: how brief reimmersion in their native country impacts migrants’ native language access
Authors: Casado Alba , Walther Jonas , Wolna Agata , Szewczyk Jakub , Sorace Antonella , Wodniecka Zofia
Published: May 2023

The study explores how native language (L1) lexical access is affected by immersion in a second-language (L2) environment, and by short-term reimmersion in the L1 environment. We compared the L1 picture-naming performance of Polish–English bilinguals living in the UK (migrants) against that of bilinguals living in Poland (controls). Each group was tested twice: the migrants while in the UK (L2 immersion) and after visiting Poland (L1 reimmersion); the controls twice in their L1 environment. Contrary to our expectations, there was no main effect of group, thus suggesting that L2 immersion per se does not impact L1 lexical access. Nevertheless, migrants benefitted from L1 reimmersion by showing faster naming latencies for high-frequency words after a short visit to their home country, probably due to more opportunities to encounter these words. Overall, the study shows that the cognitive system is sensitive to the language environment by quickly adapting the activation level of lexical items.
Diane Miller: President of BIALL
Authors: Breslin Mike
Published: May 2023

Legal Information Management co-editors Jas Breslin and Mike Breslin sat down with current President Diane Miller to find out what her role involves, where BIALL is going, and how members can get so much more from a deeper involvement with the organisation.
The BIALL Law Firm Library Survey 2022
Authors: Bowl Catherine , Miller Diane
Published: May 2023

It goes without saying that few things are more important to information professionals than data, all the more so when that data relates to their own profession. Which is why this third edition of BIALL's Law Firm Survey is so welcome, providing, as it does, data on a range of different information departments working in the library space, while also drawing comparisons from the results of earlier surveys. Here Catherine Bowl and Diane Miller explain the process of compiling the survey, its findings, and the interesting trends it has highlighted.
Raiders of the Lost Archive
Authors: Breslin Mike , Breslin Jas
Published: May 2023

In the first in a series of regular articles reviewing archived issues of Legal Information Management and The Law Librarian – as the journal was once known – the LIM editors examine the issues, and indeed the issues, of 1973.
Recruitment in the Corporate Legal Industry Panel Discussion
Authors: Asbjornsen Caroline
Published: May 2023

Recruitment within the legal information sector has been challenging in recent years, in both the UK and the US, with a market that has been heavily skewed in favour of applicants. Which is why the City Legal Information Group (CLIG) hosted a virtual conference in late February to look at the current state of the recruitment market, the best ways to hire the very best people, and also the methods individuals might employ to find work in the sector themselves. Here Caroline Asbjornsen, a researcher at Watson Farley & Williams LLP and a member of the CLIG committee, talks us through what turned out to be a fascinating discussion.
Conserved stromal–immune cell circuits secure B cell homeostasis and function
Authors: Lütge Mechthild , De Martin Angelina , Gil-Cruz Cristina , Perez-Shibayama Christian , Stanossek Yves , Onder Lucas , Cheng Hung-Wei , Kurz Lisa , Cadosch Nadine , Soneson Charlotte , Robinson Mark D. , Stoeckli Sandro J. , Ludewig Burkhard , Pikor Natalia B.
Published: May 2023

B cell zone reticular cells (BRCs) form stable microenvironments that direct efficient humoral immunity with B cell priming and memory maintenance being orchestrated across lymphoid organs. However, a comprehensive understanding of systemic humoral immunity is hampered by the lack of knowledge of global BRC sustenance, function and major pathways controlling BRC–immune cell interactions. Here we dissected the BRC landscape and immune cell interactome in human and murine lymphoid organs. In addition to the major BRC subsets underpinning the follicle, including follicular dendritic cells, PI16+ RCs were present across organs and species. As well as BRC-produced niche factors, immune cell-driven BRC differentiation and activation programs governed the convergence of shared BRC subsets, overwriting tissue-specific gene signatures. Our data reveal that a canonical set of immune cell-provided cues enforce bidirectional signaling programs that sustain functional BRC niches across lymphoid organs and species, thereby securing efficient humoral immunity.
Scrutinizing joint remote state preparation under decoherence
Authors: Iyen Cookey , Falaye Babatunde James , Liman Muhammad Sanusi
Published: May 2023

This research examines the effect of an open system containing the squeezed generalized amplitude damping channel on the joint remote preparation quantum communication protocol using a maximally entangled two-qubit state. Our findings indicate that the fidelity of a quantum system in contact with a non-zero temperature thermal bath can be enhanced by varying the squeezing parameters. These parameters include the squeezing phase of the channel $$\Phi$$
Φ
and the amount of squeezing of the channel r.
Contrasting patterns in phylogenetic and biogeographic factories of invasive grasses (Poaceae) across the globe
Authors: Pertierra Luis R. , Martínez Pablo A. , Rubalcaba Juan G. , Richardson David M. , Olalla-Tárraga Miguel A.
Published: May 2023

Grasses (Family Poaceae) are among the most successful invasive plants in the world. Here we evaluate phylogenetic and biogeographic patterns of emergence of naturalized and invasive species among grasses globally. In our data, circa 19% of the grasses are currently catalogued as invasive and almost 38% are listed as naturalized; these are among the highest ratios for single families of organisms. Remarkably, most tribes of grasses contain numerous naturalized and invasive species, suggesting that the invasion success is rooted broadly in ancestral traits in the Poaceae. Moreover, the probability of invasiveness is positively related to the diversification rates in the family also suggesting a link with recent radiation events. The phylogenetic distribution of the invasive condition is neither strongly conserved nor purely random. Phylogenetic clumping levels also vary between Poaceae subclades. We postulate that this diffuse clumping could be partially attributed to the expression of labile traits that contribute to species invasiveness. In addition, floristic regions (biomes and biogeographic realms) have different proportions of invasive species, with the temperate Palearctic region having the highest ratio of invasive vs. non-invasive species. The phylodiversity of aliens across regions is also variable in space. Comparison of alien phylodiversity levels across biogeographic realms and biomes reveals regions producing highly restricted invasive lineages and others where the diversity of aliens exported is no different from global mean diversity levels in grasses. Elucidating the evolutionary patterns and drivers of invasiveness is useful for understanding and managing invasions, with the low phylogenetic structure of alien grasses warning of their overall high invasiveness potential.
Base-mediated ynone-isocyanide [3+2] cycloaddition: a general method to 2,3,4-tri-substituted 1-H-pyrroles and bis-pyrroles
Authors: Kumar Ankit , Mishra Pawan K. , Verma Akhilesh K.
Published: May 2023

A general method for the synthesis of functionalized pyrroles and bis-pyrroles from ynones under transition-metal-free conditions in good to excellent yields has been developed.
Polysulfide synthesisviavisible-light-induced heteroarene-migratory dithiosulfonylation reaction
Authors: Wang Baoxu , Hu Zijing , Huang Lu , Ren Xiaorui , Gao Qianwen , Wang Xi
Published: May 2023

A visible-light-induced radical cascade heteroarene-migratory dithiosulfonylation has been developed to synthesize polysulfides, which can be transformed into dihydrothiophene and homoallyl disulfide derivatives.
Rotational spectroscopy of hydrogen-bonded binary trifluoro-propanol conformers: conformational diversity, preference and abundances in a jet expansion
Authors: Mort Alex N. , Xie Fan , Hazrah Arsh S. , Xu Yunjie
Published: May 2023

The rich conformational landscape of the hydrogen-bonded 3,3,3-trifluoropropanol binary cluster was explored using chirped pulse Fourier transform microwave spectroscopy and DFT calculations, revealing interesting conformational conversion paths.
The current status in computational exploration of Pt(iv) prodrug activation by reduction
Authors: Ponte Fortuna , Scoditti Stefano , Mazzone Gloria , Sicilia Emilia
Published: May 2023

This perspective focuses on computational studies for the reduction mechanism of octahedral PtIVcomplexes to afford the active PtIIspecies. All the plausible pathways depending on specific axial leaving ligands and reducing agents were addressed.
In silico design of miniprotein to inhibit SARS-CoV-2 variant Omicron spike protein
Authors: Wu Jianhua , Zhang Hong-Xing , Zhang Jilong
Published: May 2023

Both single- and double-point mutant inhibitors M7E, M7E + M43W, and M7E + M43Y based on the initial inhibitor AHB2 expressed enhanced inhibitory ability against the SARS-CoV-2 variant of Omicron RBD protein.
Polarity-extended 8 − Neff rule for semiconducting main-group compounds with the TiNiSi-type of crystal structure
Authors: Freccero Riccardo , Grin Yuri , Wagner Frank R.
Published: May 2023

For semiconducting main-group compounds of the TiNiSi-type of structure quantum-chemically obtained polar-covalent bonding data in position-space are consistently transferred to and analyzed within the framework of the polarity-extended 8 − Neff rule.
Spectroscopic characterization and the reactivity of a high valent (L)Cu(iii) species supported by a proline-based pseudopeptide
Authors: Eerlapally Raju , Gupta Sikha , Awasthi Ayushi , Kumar Rakesh , Draksharapu Apparao
Published: May 2023

Inspired by copper-based metalloenzymes, we aim to incorporate amino acids into our ligands to facilitate high valent Cu(iii) species by employing various chemical oxidants, that serve as functional and structural models for copper-based enzymes.
Defective Cd0.3Zn0.7S twin crystal/Ag3PO4 Z-scheme heterojunctions toward optimized visible-light-driven photocatalytic hydrogen evolution
Authors: Chen Jie , Yu Haitao , Xie Ying , Li Zhenzi , Zhou Wei
Published: May 2023

To improve the performance of catalysts, the most used strategies is to combine two or more semiconductors with appropriate energy band structures to construct heterojunctions for an extended light absorption range and effective charge separation.
Engineering defective trimetallic metal–organic framework nanosheets for advanced water oxidation electrocatalysis
Authors: Xu Hui , Wang Cheng , He Guangyu , Chen Haiqun
Published: May 2023

A facile solvothermal method for the universal synthesis of trimetallic NiFeM (M = Zn, Mn, Cu, Pb, and Cd) MOF nanosheets with superb electrocatalytic OER performance is proposed.
Novel Pd(ii) pincer complexes bearing salicylaldimine-based benzothiazole derivatives: synthesis, structural characterization, DNA/BSA binding, and biological evaluation
Authors: Wongsuwan Sutthida , Chatwichien Jaruwan , Sirisaksoontorn Weekit , Chainok Kittipong , Songsasen Apisit , Chotima Ratanon
Published: May 2023

Pd(ii) pincer complexes as potential anticancer agents: the study of proposed mechanism of action.
Heterojunctions of N-deficient g-C3N4/1T@2H-MoS2 with interfacial C–S–Mo coordination for enhanced photocatalytic activity
Authors: Chen Changzhao , Li Yuanzhi , Wang Xing
Published: May 2023

Heterojunctions of N-deficient g-C3N4/1T@2H-MoS2 with interfacial C–S–Mo coordination are obtained, which exhibits very excellent photocatalytic activity.
Highly diastereoselective Heck–Matsuda reaction with pyrazolyl diazonium salts
Authors: Bellina F. , Berti F. , Bertozzi S. M. , Bandiera T. , Bertozzi F.
Published: May 2023

Novel pyrazolyl-derived diazonium tetrafluoroborate salts were used in the palladium-catalyzed Heck–Matsuda reaction for the diastereoselective synthesis of highly substituted cyclopenten-ols/-amines.
Dibenzoacridines: synthesis by alkyne–carbonyl-metathesis and properties
Authors: Ammon Erich , Heine Paul , Cordero Miguel Andre Argüello , Lochbrunner Stefan , Villinger Alexander , Ehlers Peter , Langer Peter
Published: May 2023

Dibenzoacridines were prepared by alkyne–carbonyl-metathesis and the optical properties of the products were studied.
Don’t sweat the small stuff: skin mechanisms of sodium homeostasis and associations with long-term blood pressure
Authors: Speed Joshua S. , Pollock David M. , Clemmer John S.
Published: May 2023

Despite the overwhelming evidence that the kidney is the principal regulator of chronic blood pressure though the ability to sense pressure and adjust blood volume accordingly, recent clinical and preclinical evidence suggests that skin clearance of Na+ through sweat significantly contributes to long-term blood pressure and risk of hypertension. Evidence indicates that changes in skin Na+ content negatively associate with renal function, and factors that influence the concentration of Na+ in sweat are affected by major regulators of Na+ excretion by the kidney such as angiotensin and aldosterone. In addition, known regulatory mechanisms that regulate the amount of sweat produced do not include changes in Na+ intake or blood volume. Because of these reasons, it will be hard to quantify the contribution of Na+ clearance through sweat to blood pressure regulation and hypertension. While Chen et al. demonstrate significant negative associations between sweat Na+ concentration and blood pressure, it is likely that Na+ clearance through the skin has a short-term influence on blood pressure and sweat Na+ concentration is most likely a biomarker of renal function and its key role in hypertension.
Immunologically relevant effects of radiation therapy on the tumor microenvironment
Authors: Galassi Claudia , Klapp Vanessa , Formenti Silvia C. , Demaria Sandra , Galluzzi Lorenzo
Published: May 2023

Focal radiation therapy (RT) has been successfully employed to clinically manage multiple types of cancer for more than a century. Besides being preferentially cytotoxic for malignant cells over their nontransformed counterparts, RT elicits numerous microenvironmental alterations that appear to factor into its therapeutic efficacy. Here, we briefly discuss immunostimulatory and immunosuppressive microenvironmental changes elicited by RT and their impact on tumor recognition by the host immune system.