bluuebunny/crossref_metadata_2025 huggingface dataset:
Late Quaternary sea level, isostatic response, and sediment dispersal along the Queen Charlotte fault
Authors: Barrie J. Vaughn , Greene H. Gary , Conway Kim W. , Brothers Daniel S.
Published: January 2021

The active Pacific margin of the Haida Gwaii and southeast Alaska has been subject to vigorous storm activity, dramatic sea-level change, and active tectonism since glacial times. Glaciation was minimal along the western shelf margin, except for large ice streams that formed glacial valleys to the shelf break between the major islands of southeast Alaska and Haida Gwaii. Upon deglaciation, sediment discharge was extensive, but it terminated quickly due to rapid glacial retreat and sea-level lowering with the development of a glacio-isostatic forebulge, coupled with eustatic lowering. Glacial sedimentation offshore ended soon after 15.0 ka. The shelf became emergent, with sea level lowering by, and possibly greater than, 175 m. The rapid transgression that followed began sometime before 12.7 ka off Haida Gwaii and 12.0 ka off southeast Alaska, and with the extreme wave-dominated environment, the unconsolidated sediment that was left on the shelf was effectively removed. Temperate carbonate sands make up the few sediment deposits presently found on the shelf.

The Queen Charlotte fault, which lies just below the shelf break for most of its length, was extensively gullied during this short period of significant sediment discharge, when sediment was transported though the glacial valleys and across the narrow shelf through fluvial and submarine channels and was deposited offshore as sea level dropped. The Queen Charlotte fault became the western terminus of the glacio-isostatic forebulge, with the fault acting as a hinged flap taking up the uplift and collapse along the fault of 70+ m. This may have resulted in the development of the distinctive fault valley that presently acts as a very linear channel pathway for sediment throughout the fault system.
Post-Streptococcus mitisinfection polyserositis
Authors: Grech Paula , Mangion Jessica , Vella Sandro
Published: January 2021

We report a case of a 42-year-old man who presented with acute epigastric and retrosternal chest pain and exertional dyspnoea, and was subsequently diagnosed with polyserositis secondary to post-Streptococcal mitisinfection. A CT scan showed a large pericardial effusion requiring pericardiocentesis, small bilateral pleural effusions and small amount of ascites. Several serological tests were done, which were all found to be normal. Pericardial and pleural fluid aspirates revealed an exudate. Culture of the pleural fluid yielded growth ofS.  mitisand this was deemed the cause of the polyserositis, which is rare. The patient made a spontaneous recovery. He was started on colchicine by the cardiologists to help prevent pericardial fluid recurrence and this was continued for 3 months. A dental review confirmed the presence of dental caries, the possible source of infection. On follow-up, the patient remained well with no further relapses.
Lower lumbar back pain occurring with transient hip osteoporosis: complication of prolonged suffering and neck of femur fracture in a 24-year-old pregnant patient
Authors: Al-Dourobi Karim , Corbaz Jocelyn , Bauer Stefan , Ngassom Leumessi Eric
Published: January 2021

Six days after a normal delivery, a 24-year-old woman with atraumatic lumbosacral pain radiating to the left groin was referred to the orthopaedic surgeon due to worsening pain and impossible load bearing on the left lower limb. Standard pelvic radiographs revealed an unstable displaced left neck of femur (NOF) fracture. A CT scanner and MRI showed diffuse osteopaenia of the left proximal femur and the corresponding acetabulum. A diagnosis of transient osteoporosis of the hip (TOH) complicated by a pathological displaced subcapital NOF fracture was established. The patient underwent total hip arthroplasty without complication and recovered excellent function after rehabilitation. Awareness of the differential diagnosis of TOH in pregnancy, a high index of suspicion and early MRI to make an early diagnosis and to prevent devastating fracture complications are mandatory.
Return to play with hypertrophic cardiomyopathy: are we moving too fast? A critical review
Authors: Drezner Jonathan A , Malhotra Aneil , Prutkin Jordan M , Papadakis Michael , Harmon Kimberly G , Asif Irfan M , Owens David S , Marek Joseph C , Sharma Sanjay
Published: January 2021

The diagnosis of a potentially lethal cardiovascular disease in a young athlete presents a complex dilemma regarding athlete safety, patient autonomy, team or institutional risk tolerance and medical decision-making. Consensus cardiology recommendations previously supported the ‘blanket’ disqualification of athletes with hypertrophic cardiomyopathy (HCM) from competitive sport. More recently, epidemiological studies examining the relative contribution of HCM as a cause of sudden cardiac death (SCD) in young athletes and reports from small cohorts of older athletes with HCM that continue to exercise have fueled debate whether it is safe to play with HCM. Shared decision-making is endorsed within the sports cardiology community in which athletes can make an informed decision about treatment options and potentially elect to continue competitive sports participation. This review critically examines the available evidence relevant to sports eligibility decisions in young athletes diagnosed with HCM. Histopathologically, HCM presents an unstable myocardial substrate that is vulnerable to ventricular tachyarrhythmias during exercise. Studies support that young age and intense competitive sports are risk factors for SCD in patients with HCM. We provide an estimate of annual mortality based on our understanding of disease prevalence and the incidence of HCM-related SCD in different athlete populations. Adolescent and young adult male athletes and athletes participating in a higher risk sport such as basketball, soccer and American football exhibit a greater risk. This review explores the potential harms and benefits of sports disqualification in athletes with HCM and details the challenges and limitations of shared decision-making when all parties may not agree.
Risk of morbidity and mortality in patients with type 2 diabetes treated with sodium-glucose cotransporter-2 inhibitor and/or dipeptidyl peptidase-4 inhibitor: a nationwide study
Authors: Sütő Gábor , Molnár Gergő A , Rokszin Gyorgy , Fábián Ibolya , Kiss Zoltan , Szekanecz Zoltán , Poór Gyula , Jermendy György , Kempler Peter , Wittmann István
Published: January 2021

Introduction

Mortality and disability in diabetes mellitus are determined mostly by cardiovascular complications and cancer. The impact of dipeptidyl peptidase-4 inhibitor (DPP-4i) and sodium-glucose cotransporter-2 inhibitor (SGLT2i) monotherapy or combination on long-term complications of type 2 diabetes mellitus was studied.

Research design and methods

Patients with type 2 diabetes treated with DPP-4i or SGLT2i during a 3-year period were identified in the database of the National Institute of Health Insurance Fund in Hungary. All-cause mortality, acute myocardial infarction, stroke, hospitalization for heart failure (HHF), lower limb amputation (LLA) and cancer were assessed. Outcomes of add-on SGLT2i to DPP-4i treatment in comparison with switching DPP-4i therapy to SGLT2i were also evaluated. After propensity score matching, survival analysis was performed with a Cox proportional hazards model.

Results

After propensity score matching, both SGLT2i and DPP-4i groups included 18 583 patients. All-cause mortality (HR, 0.80; 95% CI 0.68 to 0.94; p=0.0057), HHF (HR, 0.81; 95% CI 0.71 to 0.92; p=0.0018), and risk of cancer (HR, 0.75; 95% CI 0.66 to 0.86; p<0.0001) were lower in the SGLT2i population compared with DPP-4i. Risk of LLA was higher in the SGLT2i group (HR, 1.35; 95% CI 1.03 to 1.77; p=0.0315). SGLT2i in combination with DPP-4i results in lower all-cause mortality (HR, 0.46; 95% CI 0.31 to 0.67; p=0.0001), with a lower trend in stroke, LLA, HHF and cancer, but without any statistical difference.

Conclusions

SGLT2i treatment leads to a lower risk of overall mortality, HHF and cancer when compared with DPP-4i treatment. Adding SGLT2i to DPP-4i instead of switching from DPP-4i to SGLT2i further lowers the risk of all-cause mortality.
Do the combined blood pressure effects of exercise and antihypertensive medications add up to the sum of their parts? A systematic meta-review
Authors: Pescatello Linda S , Wu Yin , Gao Simiao , Livingston Jill , Sheppard Bonny Bloodgood , Chen Ming-Hui
Published: January 2021

Objective

To compare the blood pressure (BP) effects of exercise alone (EXalone), medication alone (MEDSalone) and combined (EX+MEDScombined) among adults with hypertension.

Data sources

PubMed, Scopus, Cumulative Index to Nursing and Allied Health Literature, SPORTDiscus and the Cochrane Library.

Eligibility criteria

Randomised controlled trails (RCTs) or meta-analyses (MAs) of controlled trials that: (1) involved healthy adults>18 year with hypertension; (2) investigated exercise and BP; (3) reported preintervention and postintervention BP and (4) were published in English. RCTs had an EX+MEDScombined arm; and an EXalone arm and/or an MEDSalone arm; and MAs performed moderator analyses.

Design

A systematic network MA and meta-review with the evidence graded using the Physical Activity Guidelines for Americans Advisory Committee system.

Outcome

The BP response for EXalone, MEDSalone and EX+MEDScombined and compared with each other.

Results

Twelve RCTs qualified with 342 subjects (60% women) who were mostly physically inactive, middle-aged to older adults. There were 13 qualifying MAs with 28 468 participants (~50% women) who were mostly Caucasian or Asian. Most RCTs were aerobic (83.3%), while the MAs involved traditional (46%) and alternative (54%) exercise types. Strong evidence demonstrates EXalone, MEDSalone and EX+MEDScombined reduce BP and EX+MEDScombined elicit BP reductions less than the sum of their parts. Strong evidence indicates EX+MEDScombined potentiate the BP effects of MEDSalone. Although the evidence is stronger for alternative than traditional types of exercise, EXaloneelicits greater BP reductions than MEDSalone.

Conclusions

The combined BP effects of exercise and medications are not additive or synergistic, but when combined they bolster the antihypertensive effects of MEDSalone.

PROSPERO registration number

The protocol is registered at PROSPERO CRD42020181754.
Disability pension and mortality in individuals with specific somatic and mental disorders: examining differences between refugees and Swedish-born individuals
Authors: Helgesson Magnus , Rahman Syed , Saboonchi Fredrik , Mittendorfer Rutz Ellenor
Published: January 2021

Background

More than half a million refugees have arrived to Sweden during the last decade. The aim was to investigate differences between refugees and Swedish-born individuals regarding different specific somatic and mental disorders, and subsequent disability pension and mortality.

Methods

All refugees (n=239 742) and Swedish-born individuals (n=4 133 898), aged 19–60 years, resident in Sweden on 31st of December in 2009 were included in this population-based prospective cohort study. Data from six nationwide Swedish registers were linked by the unique anonymised identification number. HRs with 95% CIs were computed for disability pension and mortality 2010–2013 by Cox regression models.

Results

Compared with their Swedish-born counterparts with mental or somatic diagnoses, refugees with these diagnoses had a higher risk of subsequent disability pension and a lower risk of mortality. Highest estimates for disability pension were seen for refugees with neoplasm (HR: 1.72; 95% CI: 1.56 to 1.91), musculoskeletal disorders (HR: 1.57; 95% CI: 1.47 to 1.67), diseases of the circulatory system (HR: 1.33; 95% CI: 1.22 to 1.45), depressive disorders (HR: 1.31; 95% CI: 1.21 to 1.41) and diabetes mellitus (HR: 1.30; 95% CI: 1.15 to 1.47). The risk of mortality was lowest for refugees with regard to bipolar disorders (HR: 0.37; 95% CI: 0.16 to 0.82), post-traumatic stress disorder (HR: 0.37; 95% CI: 0.25 to 0.54) and least pronounced in regard to neoplasm (HR: 0.69; 95% CI: 0.61 to 0.77) compared with Swedish-born with similar disorders.

Conclusion

Refugees have a generally higher risk of disability pension compared with Swedish-born with specific somatic and mental disorders. Despite this, refugees with all specific disorders have lower risk estimates of mortality, probably due to a healthy selection. The higher risk of disability pension might therefore be due to other causes besides poor health.
Tisagenlecleucel infusion in patients with relapsed/refractory ALL and concurrent serious infection
Authors: Hall Erin M , Yin Dwight E , Goyal Rakesh K , Ahmed Atif A , Mitchell Grace S , St. Peter Shawn D , Flatt Terrie G , Ahmed Ibrahim A , Li Weijie , Hendrickson Richard J , August Keith J , Myers G Doug
Published: January 2021

Background

Tisagenlecleucel, an anti-CD19 chimeric antigen receptor T (CAR-T) cell therapy, has demonstrated durable efficacy and a manageable safety profile in pediatric and young adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) in the ELIANA pivotal trial and real-world experience. Experience from investigator-led studies prior to ELIANA suggests that infections and inflammatory conditions may exacerbate the severity of cytokine release syndrome (CRS) associated with CAR-T cell therapy, leading to extreme caution and strong restrictions for on-study and commercial infusion of tisagenlecleucel in patients with active infection. CRS intervention with interleukin (IL)-6 blockade and/or steroid therapy was introduced late in the course during clinical trials due to concern for potential negative effect on efficacy and persistence. However, earlier CRS intervention is now viewed more favorably. Earlier intervention and consistency in management between providers may promote broader use of tisagenlecleucel, including potential curative therapy in patients who require remission and recovery of hematopoiesis for management of severe infection.

Main body

Patient 1 was diagnosed with B-ALL at 23 years old. Fourteen days before tisagenlecleucel infusion, the patient developed fever and neutropenia and was diagnosed with invasive Mucorales infection and BK virus hemorrhagic cystitis. Aggressive measures were instituted to control infection and to manage prolonged cytopenias during CAR-T cell manufacturing. Adverse events, including CRS, were manageable despite elevated inflammatory markers and active infection. The patient attained remission and recovered hematopoiesis, and infections resolved. The patient remains in remission ≥1 year postinfusion.

Patient 2 was diagnosed with pre–B-ALL at preschool age. She developed severe septic shock 3 days postinitiation of lymphodepleting chemotherapy. After receiving tisagenlecleucel, she experienced CRS with cardiac dysfunction and extensive lymphadenopathy leading to renovascular compromise. The patient attained remission and was discharged in good condition to her country of origin. She remained in remission but expired on day 208 postinfusion due to cardiac arrest of unclear etiology.

Conclusions

Infusion was feasible, and toxicity related to tisagenlecleucel was manageable despite active infections and concurrent inflammation, allowing attainment of remission in otherwise refractory pediatric/young adult ALL. This may lead to consideration of tisagenlecleucel as a potential curative therapy in patients with managed active infections.
Mechanisms underlying low-clinical responses to PD-1/PD-L1 blocking antibodies in immunotherapy of cancer: a key role of exosomal PD-L1
Authors: Yin Zi , Yu Min , Ma Tingting , Zhang Chuanzhao , Huang Shanzhou , Karimzadeh Mohammad Reza , Momtazi-Borojeni Amir Abaas , Chen Sheng
Published: January 2021

Exosomes, as the main group of extracellular vesicles, are biologically active lipid-bilayer vesicles that are naturally released from different types of normal or tumor cells. These vesicles play an important role in intercellular communication and influence the extracellular environment and the immune system. Emerging evidence demonstrates that cancer-derived exosomes are enriched in immunosuppressive proteins, such as the programmed death-ligand 1 (PD-L1). PD-L1 and its receptor programmed cell death protein 1 (PD-1) are the key immune checkpoint molecules that promote tumor progression via negative regulation of immune responses. PDL-1 is highly expressed on the surface of tumor cells and binds to PD-1 on the surface of activated T cells, leading to suppression of T cells, which consequently enables cancer cells to escape antitumor immunity. Currently, there are several Food and Drug Administration-approved monoclonal antibodies blocking PD-1/PD-L1 interaction, which are clinically used for cancer treatment. However, despite impressive treatment outcomes, some patients show poor response to PD-1/PD-L1 blockade. Of note, tumor-derived exosomes containing PD-L1 can recapitulate the effect of cell-surface PD-L1. There is evidence that reveals a significant association between levels of circulating exosomal PD-L1 and rate of response to anti-PD-1/PD-L1 antibody therapy. The present article reviews the role of exosomal PDL-1 in the therapeutic resistance to anti-PD-1/PD-L1 treatment. Importantly, it is suggested that the removal of exosomal PDL-1 could serve as a therapeutic adjuvant for enhancing the efficacy of anti-PD-1/PD-L1 therapy in patients with cancer.
Irregular pulsation of intracranial unruptured aneurysm detected by four-dimensional CT angiography is associated with increased estimated rupture risk and conventional risk factors
Authors: Zhang Jianjian , Li Xiao , Zhao Bing , Zhang Jin , Sun Beibei , Wang Lingling , Ding Shenghao , Liu Xiangyu , Yan Jing , Mossa-Basha Mahmud , Liu Xiaosheng , Wan Jieqing , Zhao Huilin , Xu Jianrong , Zhu Chengcheng
Published: January 2021

Background

Intracranial aneurysms (IAs) are common in the population and current imaging-based rupture risk assessment needs to be refined. We aimed to use four-dimensional CT angiography (4D-CTA) to investigate the associations of irregular pulsation of IAs with conventional risk factors and the estimated rupture risk.

Methods

One hundred and five patients with 117 asymptomatic IAs underwent 4D-CTA. Geometric and morphologic parameters were measured and the presence of irregular pulsation (defined as a temporary focal protuberance ≥1 mm on more than three successive frames) was identified on 4D-CTA movies. One- and 5 year aneurysm rupture risk were estimated using UCAS and PHASES calculators. Univariate and multivariate analyses were performed to investigate the conventional risk factors associated with irregular pulsation.

Results

Irregular pulsation was observed in 41.0% (48/117) of IAs. Aneurysm size (OR=1.380, 95% CI 1.165 to 1.634), irregular shape (OR=3.737, 95% CI 1.108 to 12.608), and internal carotid artery location (OR=0.151, 95% CI 0.056 to 0.403) were independently associated with irregular pulsation (P<0.05). Aneurysms with irregular pulsation had more than a 6-fold higher estimated rupture risk (1- and 5-year risk [95% CI], 1.56% [0.42%–3.91%], and 2.40% [1.30%–4.30%], respectively) than aneurysms without irregular pulsation (0.23% [0.14%–0.78%] and 0.40% [0.40%–1.30%], respectively) (P<0.001).

Conclusions

IAs with irregular pulsation are associated with larger size, irregular-shape, and non-ICA origin, and have more than a 6-fold higher estimated 1- and 5-year rupture risk than aneurysms without irregular pulsation. Irregular pulsation should be validated in future longitudinal studies to determine its predictive value for aneurysm growth and rupture.
Short-term association among meteorological variation, outdoor air pollution and acute bronchiolitis in children in a subtropical setting
Authors: Leung Shuk Yu , Lau Steven Yuk Fai , Kwok Ka Li , Mohammad Kirran N. , Chan Paul Kay Sheung , Chong Ka Chun
Published: January 2021

Objectives

To examine the association among acute bronchiolitis-related hospitalisation in children, meteorological variation and outdoor air pollution.

Methods

We obtained the daily counts of acute bronchiolitis-related admission of children≤2 years old from all public hospitals, meteorological data and outdoor air pollutants’ concentrations between 1 January 2008 and 31 December 2017 in Hong Kong. We used quasi-Poisson generalised additive models together with distributed lag non-linear models to estimate the associations of interest adjusted for confounders.

Results

A total of 29 688 admissions were included in the analysis. Increased adjusted relative risk (ARR) of acute bronchiolitis-related hospitalisation was associated with high temperature (ambient temperature and apparent temperature) and was marginally associated with high vapour pressure, a proxy for absolute humidity. High concentration of NO2 was associated with elevated risk of acute bronchiolitis admission; the risk of bronchiolitis hospitalisation increased statistically significantly with cumulative NO2 exposure over the range 66.2–119.6 µg/m3. For PM10, the significant effect observed at high concentrations appears to be immediate but not long lasting. For SO2, ARR increased as the concentration approached the 75th percentile and then decreased though the association was insignificant.

Conclusions

Acute bronchiolitis-related hospitalisation among children was associated with temperature and exposure to NO2 and PM10 at different lag times, suggesting a need to adopt sustainable clean air policies, especially to target pollutants produced by motor vehicles, to protect young children’s health.
Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance
Authors: Shamshoum Hesham , Vlavcheski Filip , MacPherson Rebecca E.K. , Tsiani Evangelia
Published: January 2021

Impaired action of insulin in skeletal muscle, termed insulin resistance, leads to increased blood glucose levels resulting in compensatory increase in insulin levels. The elevated blood glucose and insulin levels exacerbate insulin resistance and contribute to the pathogenesis of type 2 diabetes mellitus. In previous studies we found attenuation of free fatty acid-induced muscle cell insulin resistance by rosemary extract (RE). In the present study we investigated the effects of RE on high glucose (HG) and high insulin (HI)-induced muscle cell insulin resistance. Exposure of L6 myotubes to 25 mmol/L glucose and 100 nmol/L insulin for 24 h, to mimic hyperglycemia and hyperinsulinemia, abolished the acute insulin-stimulated glucose uptake, increased the serine phosphorylation of IRS-1 and the phosphorylation/activation of mTOR and p70S6K. Treatment with RE significantly improved the insulin-stimulated glucose uptake and increased the acute insulin-stimulated tyrosine phosphorylation while reducing the HG+HI-induced serine phosphorylation of IRS-1 and phosphorylation of mTOR and p70S6K. Additionally, treatment with RE significantly increased the phosphorylation of AMPK, its downstream effector ACC and the plasma membrane GLUT4 levels. Our data indicate a potential of RE to counteract muscle cell insulin resistance and more studies are required to investigate its effectiveness in vivo.

Novelty: RE phosphorylated muscle cell AMPK and ACC under both normal and HG+HI conditions. The HG+HI-induced serine phosphorylation of IRS-1 and activation of mTOR and p70S6K were attenuated by RE. RE restored the insulin-stimulated glucose uptake by enhancing GLUT4 glucose transporter translocation to plasma membrane.
Gluon dynamics from an ordinary differential equation
Authors: Aguilar A. C. , Ferreira M. N. , Papavassiliou J.
Published: January 2021

We present a novel method for computing the nonperturbative kinetic term of the gluon propagator from an ordinary differential equation, whose derivation hinges on the central hypothesis that the regular part of the three-gluon vertex and the aforementioned kinetic term are related by a partial Slavnov–Taylor identity. The main ingredients entering in the solution are projection of the three-gluon vertex and a particular derivative of the ghost-gluon kernel, whose approximate form is derived from a Schwinger–Dyson equation. Crucially, the requirement of a pole-free answer determines the initial condition, whose value is calculated from an integral containing the same ingredients as the solution itself. This feature fixes uniquely, at least in principle, the form of the kinetic term, once the ingredients have been accurately evaluated. In practice, however, due to substantial uncertainties in the computation of the necessary inputs, certain crucial components need be adjusted by hand, in order to obtain self-consistent results. Furthermore, if the gluon propagator has been independently accessed from the lattice, the solution for the kinetic term facilitates the extraction of the momentum-dependent effective gluon mass. The practical implementation of this method is carried out in detail, and the required approximations and theoretical assumptions are duly highlighted.
A warped scalar portal to fermionic dark matter
Authors: Carmona Adrian , Castellano Ruiz Javier , Neubert Matthias
Published: January 2021

We argue that extensions of the SM with a warped extra dimension, together with a new $${\mathbb {Z}}_2$$

Z
2

-odd scalar singlet, provide a natural explanation not only for the hierarchy problem but also for the nature of fermion bulk masses and the observed dark matter relic abundance. In particular, the Kaluza-Klein excitations of the new scalar particle, which is required to naturally obtain fermion bulk masses through Yukawa-like interactions, can be the leading portal to any fermion propagating into the bulk of the extra dimension and playing the role of dark matter. Moreover, such scalar excitations will necessarily mix with the Higgs boson, leading to modifications of the Higgs couplings and branching ratios, and allowing the Higgs to mediate the coannihilation of the fermionic dark matter. We study these effects and explore the viability of fermionic dark matter in the presence of these new heavy scalar mediators both in the usual freeze-out scenario and in the case where the freeze-out happens during an early period of matter domination.
$$U(1)_{B_3-L_2}$$ explanation of the neutral current $$B-$$anomalies
Authors: Allanach B. C.
Published: January 2021

We investigate a speculative short-distance force, proposed to explain discrepancies observed between measurements of certain neutral current decays of B hadrons and their Standard Model predictions. The force derives from a spontaneously broken, gauged $$U(1)_{B_3-L_2}$$

U

(
1
)

B
3

-

L
2

extension to the Standard Model, where the extra quantum numbers of Standard Model fields are given by third family baryon number minus second family lepton number. The only fields beyond those of the Standard Model are three right-handed neutrinos, a gauge field associated with $$U(1)_{B_3-L_2}$$

U

(
1
)

B
3

-

L
2

and a Standard Model singlet complex scalar which breaks $$U(1)_{B_3-L_2}$$

U

(
1
)

B
3

-

L
2

, a ‘flavon’. This simple model, via interactions involving a TeV scale force-carrying $$Z^\prime $$

Z
′

vector boson, can successfully explain the neutral current $$B-$$

B
-

anomalies whilst accommodating other empirical constraints. In an ansatz for fermion mixing, a combination of up-to-date $$B-$$

B
-

anomaly fits, LHC direct $$Z^\prime $$

Z
′

search limits and other bounds rule out the domain 0.15 $$\hbox {TeV}< M_{Z^\prime }<$$

TeV
<

M

Z
′

<

1.9 TeV at the $$95\%$$

95
%

confidence level. For more massive $$Z^\prime $$

Z
′

s, the model possesses a flavonstrahlung signal, where pp collisions produce a $$Z^\prime $$

Z
′

and a flavon, which subsequently decays into two Higgs bosons.
Fractional Schrödinger equation in gravitational optics
Authors: Iomin Alexander
Published: January 2021

This paper addresses issues surrounding the concept of fractional quantum mechanics, related to lights propagation in inhomogeneous nonlinear media, specifically restricted to a so-called gravitational optics. Besides Schrödinger–Newton equation, we have also concerned with linear and nonlinear Airy beam accelerations in flat and curved spaces and fractal photonics, related to nonlinear Schrödinger equation, where impact of the fractional Laplacian is discussed. Another important feature of the gravitational optics’ implementation is its geometry with the paraxial approximation, when quantum mechanics, in particular, fractional quantum mechanics, is an effective description of optical effects. In this case, fractional-time differentiation reflexes this geometry effect as well.
Spherically symmetric AdS black holes with smeared mass distribution
Authors: Mourad M. F. , Abdelgaber M.
Published: January 2021

In this paper, we study the thermodynamics properties of noncommutative NC (3 + 1)-dimensional in the spherically symmetric AdS black holes. The solution of equations of motion in AdS spacetime using a general distribution mass is studied. The results show that there exist AdS4 black holes only for the non-Gaussian distributions, while for the Gaussian distributions, Nariai numbers do not exist in case of small values of cosmological constant [Formula: see text] while Nariai numbers exist and tend to zero for large values of [Formula: see text]. Moreover, we show that there is an effect of [Formula: see text] on the Hawking temperature of black hole and this effect disappears when the Hawking temperature tends to zero. Finally, it turns out that the behavior of free energy does not change with the change of [Formula: see text], but its value increases with increasing [Formula: see text].
An improved E-payment protocol based on quantum blind signature without entanglement
Authors: Gou Xiang-Lin , Shi Run-Hua , Shi Ze , Li Kun-Chang
Published: January 2021

E-payment plays an important role in modern daily life, so the security problem of E-payment has been widely concerned by researchers. In a recent paper [Int. J. Theor. Phys. 57, 2657 (2018)], the authors presented a trusted third-party E-payment protocol based on quantum blind signature without entanglement. In this paper, we show that there is a serious security flaw in their E-payment protocol. That is, the partial keys will be disclosed by performing a simple attack strategy. Furthermore, we propose an improved E-payment protocol and analyze its security.
Electron Momentum Density of Nanoparticles ZrO2: A Compton Profile Study
Authors: Mohammed Sameen F. , Ghaleb Abdulhadi Mirdan , Ali Esam S.
Published: January 2021

This work investigates the electronic momentum density (EMD) distribution in nanosize zirconia (ZrO2) using the technique of Compton scattering. The ZrO2 nanoparticles (11.2[Formula: see text]nm) are synthesized of mechanical milling and characterized by SEM, XRD and TEM probes. The Compton profile [Formula: see text] of nanoZrO2 is measured by Compton spectrometer 59.54[Formula: see text]KeV Gamma rays (Americium-241) source. The study finds out that EMD in nanoZrO2 is narrower comparing in case bulk ZrO2. This study adopts the ionic-model-based free atom [Formula: see text] calculation for many configurations (Zr)[Formula: see text](O[Formula: see text])2 ([Formula: see text]) to measure the charge transfer (CT) on the compound formation. According to this study’s findings, CT values in these materials are ranged from 1.5 to 1.0 electrons from Zr to O atom.
Homological Dimensions Relative to Special Subcategories
Authors: Song Weiling , Zhao Tiwei , Huang Zhaoyong
Published: January 2021

Let [Formula: see text] be an abelian category, [Formula: see text] an additive, full and self-orthogonal subcategory of [Formula: see text] closed under direct summands, [Formula: see text] the right Gorenstein subcategory of [Formula: see text] relative to [Formula: see text], and [Formula: see text] the left orthogonal class of [Formula: see text]. For an object [Formula: see text] in [Formula: see text], we prove that if [Formula: see text] is in the right 1-orthogonal class of [Formula: see text], then the [Formula: see text]-projective and [Formula: see text]-projective dimensions of [Formula: see text] are identical; if the [Formula: see text]-projective dimension of [Formula: see text] is finite, then the [Formula: see text]-projective and [Formula: see text]-projective dimensions of [Formula: see text] are identical. We also prove that the supremum of the [Formula: see text]-projective dimensions of objects with finite [Formula: see text]-projective dimension and that of the [Formula: see text]-projective dimensions of objects with finite [Formula: see text]-projective dimension coincide. Then we apply these results to the category of modules.
Pre-Zanclean end of the Messinian Salinity Crisis: new evidence from central Mediterranean reference sections
Authors: Popescu Speranta-Maria , Cavazza William , Suc Jean-Pierre , Melinte-Dobrinescu Mihaela Carmen , Barhoun Nadia , Gorini Christian
Published: January 2021

The concept of a geologically instantaneous earliest Zanclean reflooding of the Mediterranean Basin after the Messinian drawdown has dominated geological thinking and is ingrained in the scientific literature. The base of the Trubi Formation in southern Italy, formally defined as the Zanclean Global Boundary Stratotype Section and Point (GSSP) at 5.33 Ma, has traditionally been considered as marking the marine reflooding of the Mediterranean. However, several studies provide evidence that marine reflooding occurred prior to the Zanclean GSSP, the most reliable of which comes from southern Calabria. Here, we show that the sedimentary coastal prism cropping out extensively immediately below the base of the Trubi Formation in this region and correlatable with the Arenazzolo Unit in Sicily contains a fully marine micropalaeontological association of calcareous nannofossils and dinoflagellate cysts, thus pointing to both a high sea-level and marine conditions before deposition of the Trubi Formation (i.e. in the latest Messinian).
Chapter 2.1a Ferrar Large Igneous Province: volcanology
Authors: Elliot David H. , White James D. L. , Fleming Thomas H.
Published: January 2021

Preserved rocks in the Jurassic Ferrar Large Igneous Province consist mainly of intrusions, and extrusive rocks, the topic of this chapter, comprise the remaining small component. They crop out in a limited number of areas in the Transantarctic Mountains and southeastern Australia. They consist of thick sequences of lavas and sporadic occurrences of volcaniclastic rocks. The latter occur mainly beneath the lavas and represent the initial eruptive activity, but also are present within the lava sequence. The majority are basaltic phreatomagmatic deposits and in at least two locations form immense phreatocauldrons filled with structureless tuff breccias and lapilli tuffs with thicknesses of as much as 400 m. Stratified sequences of tuff breccias, lapilli tuffs and tuffs are up to 200 m thick. Thin tuff beds are sparsely distributed in the lava sequences. Lava successions are mainly 400–500 m thick, and comprise individual lavas ranging from 1 to 230 m thick, although most are in the range of 10–100 m. Well-defined colonnade and entablature are seldom displayed. Lava sequences were confined topographically and locally ponded. Water played a prominent role in eruptive activity, as exhibited by phreatomagmatism, hyaloclastites, pillow lava and quenching of lavas. Vents for lavas have yet to be identified.
Chapter 2.2b Palmer Land and Graham Land volcanic groups (Antarctic Peninsula): petrology
Authors: Riley Teal R. , Leat Philip T.
Published: January 2021

Large-volume rhyolitic volcanism along the proto-Pacific margin of Gondwana consists of three major episodes of magmatism or ‘flare-ups’. The initial episode (V1) overlaps with the Karoo–Ferrar large igneous provinces at
c.
183 Ma. A second (V2) episode was erupted in the interval 171–167 Ma, and a third episode (V3) was emplaced in the interval 157–153 Ma. The magmatic events of the V1 and V2 episodes of the Antarctic Peninsula are reviewed here describing major and trace elements, and isotopic (Sr, Nd, O) data from rhyolitic volcanic rocks and more minor basaltic magmatism. An isotopically uniform intermediate magma developed as a result of anatexis of hydrous mafic lower crust, which can be linked to earlier, arc-related underplating. The subsequent lower-crust partial melts mixed with fractionated mafic underplate, followed by mid-crust storage and homogenization. Early Jurassic (V1) volcanic rocks of the southern Antarctic Peninsula are derived from the isotopically uniform magma, but they have mixed with melts of upper-crustal paragneiss in high-level magma chambers. The V2 rhyolites from the northern Antarctic Peninsula are the result of assimilation and fractional crystallization of the isotopically uniform magma. This process took place in upper-crust magma reservoirs involving crustal assimilants with an isotopic composition akin to that of the magma. A continental margin-arc setting was critical in allowing the development of an hydrous, fusible lower crust. Lower-crustal anatexis was in response to mafic underplating associated with the mantle plume thought to be responsible for the contemporaneous Karoo magmatic province and rifting associated with the initial break-up of Gondwana.
A Longitudinal Study of Pervasive Display Personalisation
Authors: Mikusz Mateusz , Shaw Peter , Davies Nigel , Nurmi Petteri , Clinch Sarah , Trotter Ludwig , Elhart Ivan , Langheinrich Marc , Friday Adrian
Published: January 2021

Widespread sensing devices enable a world in which physical spaces become personalised in the presence of mobile users. An important example of such personalisation is the use of pervasive displays to show content that matches the requirements of proximate viewers. Despite prior work on prototype systems that use mobile devices to personalise displays, no significant attempts to trial such systems have been carried out. In this article, we report on our experiences of designing, developing and operating the world’s first comprehensive display personalisation service for mobile users. Through a set of rigorous quantitative measures and 11 potential user/stakeholder interviews, we demonstrate the success of the platform in realising display personalisation, and offer a series of reflections to inform the design of future systems.
Detecting Depression and Predicting its Onset Using Longitudinal Symptoms Captured by Passive Sensing
Authors: Chikersal Prerna , Doryab Afsaneh , Tumminia Michael , Villalba Daniella K. , Dutcher Janine M. , Liu Xinwen , Cohen Sheldon , Creswell Kasey G. , Mankoff Jennifer , Creswell J. David , Goel Mayank , Dey Anind K.
Published: January 2021

We present a machine learning approach that uses data from smartphones and fitness trackers of 138 college students to identify students that experienced depressive symptoms at the end of the semester and students whose depressive symptoms worsened over the semester. Our novel approach is a feature extraction technique that allows us to select meaningful features indicative of depressive symptoms from longitudinal data. It allows us to detect the presence of post-semester depressive symptoms with an accuracy of 85.7% and change in symptom severity with an accuracy of 85.4%. It also predicts these outcomes with an accuracy of >80%, 11–15 weeks before the end of the semester, allowing ample time for pre-emptive interventions. Our work has significant implications for the detection of health outcomes using longitudinal behavioral data and limited ground truth. By detecting change and predicting symptoms several weeks before their onset, our work also has implications for preventing depression.
Efficient Auto-Tuning of Parallel Programs with Interdependent Tuning Parameters via Auto-Tuning Framework (ATF)
Authors: Rasch Ari , Schulze Richard , Steuwer Michel , Gorlatch Sergei
Published: January 2021

Auto-tuning is a popular approach to program optimization: it automatically finds good configurations of a program’s so-called tuning parameters whose values are crucial for achieving high performance for a particular parallel architecture and characteristics of input/output data. We present three new contributions of the Auto-Tuning Framework (ATF), which enable a key advantage in
general-purpose auto-tuning
: efficiently optimizing programs whose tuning parameters have
interdependencies
among them. We make the following contributions to the three main phases of general-purpose auto-tuning: (1) ATF
generates
the search space of interdependent tuning parameters with high performance by efficiently exploiting parameter constraints; (2) ATF
stores
such search spaces efficiently in memory, based on a novel chain-of-trees search space structure; (3) ATF
explores
these search spaces faster, by employing a multi-dimensional search strategy on its chain-of-trees search space representation. Our experiments demonstrate that, compared to the state-of-the-art, general-purpose auto-tuning frameworks, ATF substantially improves generating, storing, and exploring the search space of interdependent tuning parameters, thereby enabling an efficient overall auto-tuning process for important applications from popular domains, including stencil computations, linear algebra routines, quantum chemistry computations, and data mining algorithms.
Reliability-aware Garbage Collection for Hybrid HBM-DRAM Memories
Authors: Liu Wenjie , Akram Shoaib , Sartor Jennifer B. , Eeckhout Lieven
Published: January 2021

Emerging workloads in cloud and data center infrastructures demand high main memory bandwidth and capacity. Unfortunately, DRAM alone is unable to satisfy contemporary main memory demands. High-bandwidth memory (HBM) uses 3D die-stacking to deliver 4–8× higher bandwidth. HBM has two drawbacks: (1) capacity is low, and (2) soft error rate is high. Hybrid memory combines DRAM and HBM to promise low fault rates, high bandwidth, and high capacity. Prior OS approaches manage HBM by mapping pages to HBM versus DRAM based on hotness (access frequency) and risk (susceptibility to soft errors). Unfortunately, these approaches operate at a coarse-grained page granularity, and frequent page migrations hurt performance.

This article proposes a new class of reliability-aware garbage collectors for hybrid HBM-DRAM systems that place hot and low-risk objects in HBM and the rest in DRAM. Our analysis of nine real-world Java workloads shows that: (1) newly allocated objects in the nursery are frequently written, making them both hot and low-risk, (2) a small fraction of the mature objects are hot and low-risk, and (3) allocation site is a good predictor for hotness and risk. We propose RiskRelief, a novel reliability-aware garbage collector that uses allocation site prediction to place hot and low-risk objects in HBM. Allocation sites are profiled offline and RiskRelief uses heuristics to classify allocation sites as DRAM and HBM. The proposed heuristics expose Pareto-optimal trade-offs between soft error rate (SER) and execution time. RiskRelief improves SER by 9× compared to an HBM-Only system while at the same time improving performance by 29% compared to a DRAM-Only system. Compared to a state-of-the-art OS approach for reliability-aware data placement, RiskRelief eliminates all page migration overheads, which substantially improves performance while delivering similar SER. Reliability-aware garbage collection opens up a new opportunity to manage emerging HBM-DRAM memories at fine granularity while requiring no extra hardware support and leaving the programming model unchanged.
Analysis and Interventions in Large Network Games
Authors: Parise Francesca , Ozdaglar Asuman
Published: January 2021

We review classic results and recent progress on equilibrium analysis, dynamics, and optimal interventions in network games with both continuous and discrete strategy sets. We study strategic interactions in deterministic networks as well as networks generated from a stochastic network formation model. For the former case, we review a unifying framework for analysis based on the theory of variational inequalities. For the latter case, we highlight how knowledge of the stochastic network formation model can be used by a central planner to design interventions for large networks in a computationally efficient manner when exact network data are not available.
Carotenoids: Considerations for Their Use in Functional Foods, Nutraceuticals, Nutricosmetics, Supplements, Botanicals, and Novel Foods in the Context of Sustainability, Circular Economy, and Climate Change
Authors: Meléndez-Martínez Antonio J. , Böhm Volker , Borge Grethe Iren Andersen , Cano M. Pilar , Fikselová Martina , Gruskiene Ruta , Lavelli Vera , Loizzo Monica Rosa , Mandić Anamarija I. , Brahm Paula Mapelli , Mišan Aleksandra Č. , Pintea Adela M. , Sereikaitė Jolanta , Vargas-Murga Liliana , Vlaisavljević Sanja S. , Vulić Jelena J. , O'Brien Nora M.
Published: January 2021

Carotenoids are versatile isoprenoids that are important in food quality and health promotion. There is a need to establish recommended dietary intakes/nutritional reference values for carotenoids. Research on carotenoids in agro-food and health is being propelled by the two multidisciplinary international networks, the Ibero-American Network for the Study of Carotenoids as Functional Foods Ingredients (IBERCAROT; http://www.cyted.org ) and the European Network to Advance Carotenoid Research and Applications in Agro-Food and Health (EUROCAROTEN; http://www.eurocaroten.eu ). In this review, considerations for their safe and sustainable use in products mostly intended for health promotion are provided. Specifically, information about sources, intakes, and factors affecting bioavailability is summarized. Furthermore, their health-promoting actions and importance in public health in relation to the contribution of reducing the risk of diverse ailments are synthesized. Definitions and regulatory and safety information for carotenoid-containing products are provided. Lastly, recent trends in research in the context of sustainable healthy diets are summarized.
Molecular Origins of Polymorphism in Cocoa Butter
Authors: Ghazani Saeed M. , Marangoni Alejandro G.
Published: January 2021

Cocoa butter displays complex crystallization behavior and six crystal polymorphic forms. Although the crystal structure of cocoa butter has been studied extensively, the molecular interactions between cocoa butter triacylglycerols in relation to polymorphic transformations from metastable forms (forms III and IV) to stable crystal forms (forms V and VI) remain largely unknown. In this review, the triclinic polymorphism and melting profiles of the major triacylglycerols in cocoa butter—POP, POS, and SOS—are reviewed, and their binary and ternary phase behaviors in metastable (pseudoβ′) and stable (β2) crystal forms are discussed. We also attempt to clarify how the transformation of cocoa butter from form IV to V, as a critical step in the tempering of chocolate, is controlled by POS interactions with both POP and SOS. Moreover, we show how the crystal forms V and VI of cocoa butter are templated by crystal forms β3and β1of POS, respectively.