bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of the alternative splicing landscape in lung adenocarcinoma reveals novel prognosis signature associated with B cells
Authors: Shao Ming-Ming , Zhai Kan , Huang Zhong-Yin , Yi Feng-Shuang , Zheng Sheng-Cai , Liu Ya-Lan , Qiao Xin , Chen Qing-Yu , Wang Zhen , Shi Huan-Zhong
Published: July 2023

Background

Lung cancer is the second most commonly diagnosed cancer and the leading cause of cancer-related death. Malignant pleural effusion (MPE) is a special microenvironment for lung cancer metastasis. Alternative splicing, which is regulated by splicing factors, affects the expression of most genes and influences carcinogenesis and metastasis.

Methods

mRNA-seq data and alternative splicing events in lung adenocarcinoma (LUAD) were obtained from The Cancer Genome Atlas (TCGA). A risk model was generated by Cox regression analyses and LASSO regression. Cell isolation and flow cytometry were used to identify B cells.

Results

We systematically analyzed the splicing factors, alternative splicing events, clinical characteristics, and immunologic features of LUAD in the TCGA cohort. A risk signature based on 23 alternative splicing events was established and identified as an independent prognosis factor in LUAD. Among all patients, the risk signature showed a better prognostic value in metastatic patients. By single-sample gene set enrichment analysis, we found that among tumor-infiltrating lymphocytes, B cells were most significantly correlated to the risk score. Furthermore, we investigated the classification and function of B cells in MPE, a metastatic microenvironment of LUAD, and found that regulatory B cells might participate in the regulation of the immune microenvironment of MPE through antigen presentation and promotion of regulatory T cell differentiation.

Conclusions

We evaluated the prognostic value of alternative splicing events in LUAD and metastatic LUAD. We found that regulatory B cells had the function of antigen presentation, inhibited naïve T cells from differentiating into Th1 cells, and promoted Treg differentiation in LUAD patients with MPE.
Metabolic multireactor: Practical considerations for using simple oxygen sensing optodes for high-throughput batch reactor metabolism experiments
Authors: Kaufman Matthew H. , Torgeson Joshua , Stegen James C.
Published: July 2023

We present a system for carrying out small batch reactor oxygen consumption experiments on water and sediment samples for environmental questions. In general, it provides several advantages that can help researchers achieve impactful experiments at relatively low costs and high data quality. In particular, it allows for multiple reactors to be operated and their oxygen concentrations to be measured simultaneously, providing high throughput and high time-resolution data, which can be advantageous. Most existing literature on similar small batch-reactor metabolic studies is limited to either only a few samples, or only a few time points per sample, which can restrict the ability for researchers to learn from their experiments. The oxygen sensing system is based very directly on the work of Larsen, et al. [2011], and similar oxygen sensing technology is widely used in the literature. As such we do not delve deeply into the specifics of the fluorescent dye sensing mechanism. Instead, we focus on practical considerations. We describe the construction and operation of the calibration and experimental systems, and answer many of the questions likely to come up when other researchers choose to build and operate a similar system themselves (questions we ourselves had when we first built the system). In this way, we hope to provide an approachable and easy to use research article that can help other researchers construct and operate a similar system that can be tailored to ask their own research questions, with a minimum of confusion and missteps along the way.
A comprehensive satellite-based assessment across the Pacific Arctic Distributed Biological Observatory shows widespread late-season sea surface warming and sea ice declines with significant influences on primary productivity
Authors: Frey Karen E. , Comiso Josefino C. , Stock Larry V. , Young Luisa N. C. , Cooper Lee W. , Grebmeier Jacqueline M.
Published: July 2023

Massive declines in sea ice cover and widespread warming seawaters across the Pacific Arctic region over the past several decades have resulted in profound shifts in marine ecosystems that have cascaded throughout all trophic levels. The Distributed Biological Observatory (DBO) provides sampling infrastructure for a latitudinal gradient of biological “hotspot” regions across the Pacific Arctic region, with eight sites spanning the northern Bering, Chukchi, and Beaufort Seas. The purpose of this study is two-fold: (a) to provide an assessment of satellite-based environmental variables for the eight DBO sites (including sea surface temperature (SST), sea ice concentration, annual sea ice persistence and the timing of sea ice breakup/formation, chlorophyll-aconcentrations, primary productivity, and photosynthetically available radiation (PAR)) as well as their trends across the 2003–2020 time period; and (b) to assess the importance of sea ice presence/open water for influencing primary productivity across the region and for the eight DBO sites in particular. While we observe significant trends in SST, sea ice, and chlorophyll-a/primary productivity throughout the year, the most significant and synoptic trends for the DBO sites have been those during late summer and autumn (warming SST during October/November, later shifts in the timing of sea ice formation, and increases in chlorophyll-a/primary productivity during August/September). Those DBO sites where significant increases in annual primary productivity over the 2003–2020 time period have been observed include DBO1 in the Bering Sea (37.7 g C/m2/year/decade), DBO3 in the Chukchi Sea (48.0 g C/m2/year/decade), and DBO8 in the Beaufort Sea (38.8 g C/m2/year/decade). The length of the open water season explains the variance of annual primary productivity most strongly for sites DBO3 (74%), DBO4 in the Chukchi Sea (79%), and DBO6 in the Beaufort Sea (78%), with DBO3 influenced most strongly with each day of additional increased open water (3.8 g C/m2/year per day). These synoptic satellite-based observations across the suite of DBO sites will provide the legacy groundwork necessary to track additional and inevitable future physical and biological change across the region in response to ongoing climate warming.
Combinatorial targeting of a specific EMT/MET network by macroH2A variants safeguards mesenchymal identity
Authors: Valakos Dimitrios , Klagkou Eleftheria , Kokkalis Antonis , Polyzos Alexandros , Kyrilis Fotis L. , Banos Aggelos , Vatsellas Giannis , Pliatska Maria , Ford Ethan , Stravopodis Dimitrios J. , Thanos Dimitris
Published: July 2023

Generation of induced pluripotent stem cells from specialized cell types provides an excellent model to study how cells maintain their stability, and how they can change identity, especially in the context of disease. Previous studies have shown that chromatin safeguards cell identity by acting as a barrier to reprogramming. We investigated mechanisms by which the histone macroH2A variants inhibit reprogramming and discovered that they work as gate keepers of the mesenchymal cell state by blocking epithelial transition, a step required for reprogramming of mouse fibroblasts. More specifically, we found that individual macroH2A variants regulate the expression of defined sets of genes, whose overall function is to stabilize the mesenchymal gene expression program, thus resisting reprogramming. We identified a novel gene network (MSCN, mesenchymal network) composed of 63 macroH2A-regulated genes related to extracellular matrix, cell membrane, signaling and the transcriptional regulators Id2 and Snai2, all of which function as guardians of the mesenchymal phenotype. ChIP-seq and KD experiments revealed a macroH2A variant-specific combinatorial targeting of the genes reconstructing the MSCN, thus generating robustness in gene expression programs to resist cellular reprogramming.
Deep data mining reveals variable abundance and distribution of microbial reproductive manipulators within and among diverse host species
Authors: Medina Paloma , Russell Shelbi L. , Corbett-Detig Russell
Published: July 2023

Bacterial symbionts that manipulate the reproduction of their hosts are important factors in invertebrate ecology and evolution, and are being leveraged for host biological control. Infection prevalence restricts which biological control strategies are possible and is thought to be strongly influenced by the density of symbiont infection within hosts, termed titer. Current methods to estimate infection prevalence and symbiont titers are low-throughput, biased towards sampling infected species, and rarely measure titer. Here we develop a data mining approach to estimate symbiont infection frequencies within host species and titers within host tissues. We applied this approach to screen ~32,000 publicly available sequence samples from the most common symbiont host taxa, discovering 2,083 arthropod and 119 nematode infected samples. From these data, we estimated that Wolbachia infects approximately 44% of all arthropod and 34% of all nematode species, while other reproductive manipulators only infect 1–8% of arthropod and nematode species. Although relative titers within hosts were highly variable within and between arthropod species, a combination of arthropod host species and Wolbachia strain explained approximately 36% of variation in Wolbachia titer across the dataset. To explore potential mechanisms for host control of symbiont titer, we leveraged population genomic data from the model system Drosophila melanogaster. In this host, we found a number of SNPs associated with titer in candidate genes potentially relevant to host interactions with Wolbachia. Our study demonstrates that data mining is a powerful tool to detect bacterial infections and quantify infection intensities, thus opening an array of previously inaccessible data for further analysis in host-symbiont evolution.
Angiotensin-Converting Enzyme (ACE) level, but not ACE gene polymorphism, is associated with prognosis of COVID-19 infection: Implications for diabetes and hypertension
Authors: Elbasan Onur , Bayram Feyza , Yazan Ceyda Dinçer , Apaydın Tuğçe , Dashdamirova Saida , Polat Hamza , Arslan Ebru , Yılmaz İpek , Karimi Nastaran , Şengel Buket Ertürk , Yılmaz Sultan Seval , Çelik Ömer Faruk , Ata Pınar , Haklar Goncagül , Gözü Hülya
Published: July 2023

Background

The renin-angiotensin-aldosterone system was shown to be activated in severe COVID-19 infection. We aimed to investigate the relationship between angiotensin converting enzyme (ACE) levels, ACE gene polymorphism, type 2 diabetes (T2DM), and hypertension (HT) and the prognosis of COVID-19 infection.

Methods

This cross-sectional study analyzed the clinical features of adult patients with SARS-CoV-2 infection. ACE gene analysis and ACE level measurements were performed. The patients were grouped according to ACE gene polymorphism (DD, ID or II), disease severity (mild, moderate, or severe), and the use of dipeptidyl peptidase-4 enzyme inhibitor (DPP4i), ACE-inhibitor (ACEi) or angiotensin receptor blocker (ARB). Intensive care unit (ICU) admissions and mortality were also recorded.

Results

A total of 266 patients were enrolled. Gene analysis detected DD polymorphism in the ACE 1 gene in 32.7% (n = 87), ID in 51.5% (n = 137), and II in 15.8% (n = 42) of the patients. ACE gene polymorphisms were not associated with disease severity, ICU admission, or mortality. ACE levels were higher in patients who died (p = 0.004) or were admitted to the ICU (p<0.001) and in those with severe disease compared to cases with mild (p = 0.023) or moderate (p<0.001) disease. HT, T2DM, and ACEi/ARB or DPP4i use were not associated with mortality or ICU admission. ACE levels were similar in patients with or without HT (p = 0.374) and with HT using or not using ACEi/ARB (p = 0.999). They were also similar in patients with and without T2DM (p = 0.062) and in those with and without DPP4i treatment (p = 0.427). ACE level was a weak predictor of mortality but an important predictor of ICU admission. It predicted ICU admission in total (cutoff value >37.092 ng/mL, AUC: 0.775, p<0.001).

Conclusion

Our findings suggest that higher ACE levels, but not ACE gene polymorphism, ACEi/ARB or DPP4i use, were associated with the prognosis of COVID-19 infection. The presence of HT and T2DM and ACEi/ARB or DPP4i use were not associated with mortality or ICU admission.
Optimising quality of life for people living with heart failure in care homes: Protocol for the co-design and feasibility testing of a digital intervention
Authors: McMahon James , Brown Wilson Christine , Hill Loreena , Tierney Paul , Thompson David R. , Cameron Jan , Yu Doris , Moser Debra K. , Spilsbury Karen , Srisuk Nittaya , Schols Jos M. G. A. , van der Velden Mariëlle , Mitchell Gary
Published: July 2023

Background

Heart failure (HF) affects up to 64.3 million people globally. Advancements in pharmaceutical, device or surgical therapies, have led to patients living longer with HF. Heart failure affects 20% of care home residents, with these individuals presenting as older, frailer, and with more complex needs compared to those living at home. Thus, improving care home staff (e.g., registered nurse and care assistant) knowledge of HF has the potential to benefit patient care and reduce acute care utilization. Our aim is to co-design, and feasibility test, a digital intervention to improve care home staff knowledge of HF and optimise quality of life for those living with the condition in long-term residential care.

Methods

Using a logic model, three workstreams have been identified. Workstream 1 (WS1), comprised of three steps, will inform the ‘inputs’ of the model. First, qualitative interviews (n = 20) will be conducted with care home staff to identify facilitators and barriers in the provision of care to people with HF. Concurrently, a scoping review will be undertaken to synthesise current evidence of HF interventions within care homes. The last step will involve a Delphi study with 50–70 key stakeholders (for example care home staff, people with HF and their family and friends) to determine key education priorities related to HF. Using data from WS1, a digital intervention to improve care home staff knowledge and self-efficacy of HF will be co-designed in workstream 2 (WS2) alongside those living with HF or their carers, HF professionals, and care home staff. Lastly, workstream 3 (WS3) will involve mixed-methods feasibility testing of the digital intervention. Outcomes include staff knowledge on HF and self-efficacy in caring for HF residents, intervention usability, perceived benefits of the digital intervention on quality of life for care home residents, and care staff experience of implementing the intervention.

Discussion

As HF affects many care home residents, it is vital that care home staff are equipped to support people living with HF in these settings. With limited interventional research in this area, it is envisaged that the resulting digital intervention will have relevance for HF resident care both nationally and internationally.
Improving wheat seedling quality through deep ploughing and soil compaction at sowing in lime concretion black soil
Authors: Cui Xuejun , Wang Zhiwei , Zhuang Tengfei , Sun Jianqiang , Song Youhong
Published: July 2023

The straw incorporation in lime concretion black soil compromises the emergence and quality of winter wheat seedlings in Huaibei Plain, China, lowering the potential of wheat productivity. To overcome the disadvantage, a two-year field experiment was conducted in 2017–18 and 2018–19 to investigate the effects of different tillage modes on seedling emergence and subsequent seedling growth, and final grain yield (GY) in winter wheat. The modes are rotary tillage with compaction after sowing (RCT), rotary tillage after deep ploughing (PT) and rotary tillage after deep ploughing with compaction after sowing (PCT), with the traditional rotary tillage (RT) method as the control. Compared to RT, greater soil moisture content (SMC) at the seedling stage was observed in deep ploughing or compaction treatment, and the highest SMC was achieved in PCT; the time of reaching the maximum number of seedlings was 1 d sooner in RCT or PT, and 3 d in PCT; the seedling number in RCT, PT and PCT was significantly increased by 32.6%, 34.5% and 61.5% respectively. The population size, shoot and root growth of winter wheat in ploughing mode was significantly enhanced than that of rotary treatment at the over-wintering stage; compared to no compaction after sowing, plant growth in compaction treatments was significantly promoted with greater plant population size and height of seedlings. At harvest, GY in RCT, PT and PCT was significantly improved by 5.87%, 10.8% and 16.4%, respectively, compared to RT and the highest GY was achieved in PCT by up to 8, 350.1 kg ha-1 due to the increased spike number. In conclusion, the seedling quality in the straw incorporation practice was improved through rotary after deep ploughing and compaction after sowing for lime concretion black soil in Huaibei Plain, China or a similar soil type.
Mind and muscle: Deconstructing the uniform of masculinity in the time of AIDS
Authors: Younger Dean-Henry , Sellars Nick , James Alana
Published: July 2023

Perceptions of the boundaries of masculinity have often been questioned in menswear, with the masculine ideal continually reimagined to create a balance between itself and its counterpart, femininity. During the 1980s AIDS crisis, this adopted uniform of masculinity was subverted within queer society leading to a new male identity that contested tacit knowledge of menswear design. The focus of this article is to showcase this shift in male image and to explore how gay semiotics was associated with the development of the modern gay male stance through clothing and social empowerment, opposing the negativity that surrounded the AIDS virus. This research is personally motivated by the primary author, where he seeks to delve further into the under-researched area of queer masculinity utilizing a practical, experimental methodology. Representation of what is seen as queer masculinity is often shown as biased within society, characterizing the gay man. This project presents, through the practices of menswear design, how this characterization has developed within the context of the male body. It aims to contest the boundaries of traditional men’s tailoring, its formality and the masculine ideal that it represents, by juxtaposing it with the homoerotic art of the time and the craft of AIDS sufferers of the 1980s period. Using object-study and practical methods of deconstruction and repair of case study (bespoke and non-bespoke) men’s tailored jackets, the research manifests in physical experimentation and aesthetic visualization, which is recorded in a creative process journal. The acts of physical deconstruction and the practice of repair are then analysed through the process of design development (drawing, sourcing and sampling). The synthesized findings draw parallels with deconstructed tailoring found in vintage photographs of men at work, which are further triangulated with homoerotic photographic art of the 1980s and the act of repair found in the stitch therapy of AIDS sufferers. These are embedded in the construction of the final artefact through the practice of garment design (drawing, pattern-cutting, toiling and making) and craftsmanship (stitching by hand). The processes employed and final artefact produced document and present how ideals of masculinity in the time of AIDS can be both physically and metaphorically deconstructed, then reconstructed as a garment-based outcome (men’s tailored jacket) in practice-led research. The final artefact showcases delicacy in design through the act of stitching by hand and the repair of the deconstructed robust exteriors found in tailoring and associated with the masculine ideal.
Weird monsters and monstrous media: The adaptation of Annihilation
Authors: Giuliani Alice
Published: July 2023

This article scrutinizes Jeff VanderMeer’s novel Annihilation (2015) and its cinematic adaptation directed by Alex Garland (2018) with the aim of investigating the tensions between the weird and visualization. It argues that it is in the monstrous, weirding function of the medium in Annihilation that the weird persists. By engaging with Gilles Deleuze and Félix Guattari’s concept of becoming, I argue that the computer-generated imagery of the Annihilation film invites us to think of digital images themselves as monstrous – an articulation of the molecular, cellular, trans-species exchanges and mutations of the film, which sustains a movement towards becoming-imperceptible while becoming-visible. I argue that by releasing the monstrous, weird-making and world-making qualities of the literary and cinematic medium, the two works open us up to flowing articulations of the world that are not centred around the human but directed towards an appreciation of our existence in an incommensurable, incomprehensible, but nonetheless real and material, more-than-human embeddedness.
The phoenix rises: Peeter Rebane on Firebird
Authors: Ue Tom
Published: July 2023

In this interview, writer – director Peeter Rebane and I discuss his feature Firebird (2021). Set during the Cold War, the film centres on the real-life Sergey Fetisov’s (the film’s co-writer Tom Prior), Roman’s (Oleg Zagorodnii) and Luisa’s (Diana Pozharskaya) love triangle, exploring the decisions they make and their attendant consequences. Rebane and I examine the challenges of filming some extraordinary material – from underwater shots of the young Sergey (Romek Uibopuu) and Dima (Gregory Kibus) to shots of dozens and dozens of people seated in a concert hall, and from flying sequences to theatre ones – on an independent film budget, and how Rebane has retained integrity to the project without making compromises. We attend to the story on which Firebird was based; Rebane’s and Prior’s fidelity to their source material; how they expanded it to show, more prominently, the social and political context in which it is set; and how they altered Luisa’s character to show her perspective. We discuss Rebane’s extensive research into and recreation of the film’s world, which includes meeting with the real-life Sergey, to whom it is dedicated; casting it; and studying documentaries and photos to create costumes for its many actors and extras. Finally, Rebane and I explore the process of distributing Firebird during the COVID-19 pandemic, which has included screening the film at numerous events worldwide. This interview provides insight into both the making and the distribution of this ambitious film adaptation.
Vulnerabilidade e risco de incêndio florestal no apoio à evacuação: Proposta metodológica aplicada aos concelhos da Lousã e Sertã
Authors: Pinto Carlos , Nunes Adélia , Figueiredo Albano
Published: July 2023

A avaliação do risco de evacuação em cenário de incêndio florestal pode ser decisiva para salvar vidas humanas, principalmente em áreas de Interface Urbano-Florestal (IUF). O presente estudo pretende identificar as povoações prioritárias em termos de evacuação e assistência nos concelhos da Lousã e Sertã, através da combinação da probabilidade de ocorrência de incêndio florestal, resultante da conjugação de variáveis biofísicas, e da vulnerabilidade social, direcionada para o apoio à evacuação, sustentada em variáveis sociodemográficas, à escala da subsecção estatística. Os resultados apontam para dois concelhos extremamente suscetíveis à ocorrência de incêndio florestal e uma grande variação em termos de vulnerabilidade social, direcionada à evacuação, tendo por base as diferentes abordagens aplicadas. No risco de evacuação, as povoações localizadas em áreas de montanha e circundadas por comunidades florestais foram classificadas como prioritárias.
A kék szemszínű búzák lisztminősége és antocián tartalma
Authors: Matuz János , Óvári Judit , Ács Erika , Langó Bernadett , Berényi Attila
Published: July 2023

Kutatásunkban teszteltük a kék búzák lisztminőségét és antocianin tartalmát. A vizsgált két kék búza törzs lisztminőségi és sütőipari tulajdonságai a nem kékszemszínű malmi búzához hasonlóak voltak. A teljes kiőrlésű lisztek farinográfos értéke általában kisebb volt a fehér lisztekénél a jelentős korpatartalom miatt. A teljes kiőrlésű lisztből készült cipók térfogata is lényegesen kisebb volt a fehérlisztből készültekénél. A kék szemszínű búzák legjobban az antocianin tartalomban térnek el a nem-kék szemszínű GK Csillag közönséges malmi búzafajtától. A kék búzák teljes kiőrlésű lisztjének antocianin tartalma gyakran elérte a 100mg/kg értéket, a fehér lisztjeikben ugyanez 6,7-14,7 mg/kg volt. Az antocianin tartalomra az évjáratnak és a termőhelynek is jelentős hatása volt. A GK Csillag fehér lisztjében nem volt mérhető, teljes kiőrlésű lisztjében is csak 5,3mg/kg volt az antocianin tartalom. Mivel az antocianin tartalom a teljes kiőrlésű lisztekben a legmagasabb, ezért ezzel a liszttel lehet hatékonyan javítani, növelni a tészta- és a sütőipari termékek antocianin tartalmát.
Egyetemi oktatók stíluskommunikációs lehetősége(i)
Authors: Nagy Valéria , Nádudvari Gabriella
Published: July 2023

Az egyetemi oktatói szerep igen sokrétű, összetett. Az egyetemi oktatónak a tanítástól kezdve a mentoráláson és tutoráláson át a kutatás-fejlesztés területén is helyt kell állnia. Ahhoz azonban, hogy ezt a sokrétű egyetemi oktatói szerepet – a minőség maximája elvárásaival összhangban – át és meg lehessen élni, az egyénnek részben fel kell adnia a saját énjét, részben pedig rá kell hangolódnia azokra az értékekre, amelyek segítik az oktatói szerepéhez illeszkedő stílusa megalkotását. Tekinthetünk e feladatra úgy is, mint egy ön-fejlesztőmérnöki tevékenységre, amely természettudományos alapokon nyugszik. Az egyetemi oktatói lét ugyanis egyfajta korlátok közötti szabadság, amelynek során az egyetemi oktató egyénként próbára teszi a saját rugalmasságát, kibillen, majd újra egyensúlyi helyzetbe hozza magát. De az ’empiriokriticizmus’ létjogosultságával érvelve, felvetődik a kérdés, hogy vajon az egyensúly hogyan tud újra és újra helyreállni a kibillenések után? A stíluskommunikációs lehetőségek adta szabadság egy folyamatosan változ(tathat)ó stílussal ruházza fel az egyetemi oktatót, míg a folyamatban használja kompetenciáit, érik, gazdagodik, változik, fejlődik, kiteljesedik, miközben végbemegy a harmonizáció.
A vállalati controlling funkció digitális átalakulásának sajátosságai a hazai szolgáltató szektorban
Authors: Bajnai Péter
Published: July 2023

A controlling, mint vezetői döntéstámogató funkció napjainkban egyre inkább nélkülözhetetlenné válik a vállalatok számára. A digitalizáció új kihívásokat és fejlődési lehetőségeket jelent a controlling számára is. Átalakíthatja elvégzett feladatainak körét, eszköztárában az ERP-rendszerek túl mesterséges intelligencián alapuló és automatizációs megoldások jelenhetnek meg. A controlling digitális fejlődésére sok tényező hatással lehet, többek között a vállalatok szektor szerinti hovatartozása. A tercier szektor napjaink legjelentősebb gazdasági szektor, vállalatai pedig sajátos tulajdonságokkal rendelkeznek, a controlling rendszerek megjelenése tekintetében is. A tanulmány a kapcsolódó szakirodalom és egy magyarországi szakemberek részvételével lezajlott kérdőíves kutatás adati alapján igyekszik feltárni a controlling digitalizációja és a szolgáltató szektorhoz tartozás közötti kapcsolatot. A minta szolgáltató vállalatai körében alacsonyabb az ERP rendszerek elterjedése, a digitalizációt az anyavállalatok helyett inkább a versenytársak ösztönzik. A szolgáltató cégeknél némileg jobban ragaszkodnak a megszokott eszközökhöz és jobban féltik pozícióikat. A digitális stratégia és a kapcsolódó új KPI-ok kialakítása, továbbá a fejlett BI és RPA megoldások elterjedése tekintetében a szektor alapján nem mutatható ki különbség.
Influencerek hatása a Z-generáció fogyasztási szokásaira – feltáró kutatás
Authors: Rimóczi Csilla , Kozik Emese
Published: July 2023

Kutatásunkban az influencer marketing vásárlást befolyásoló hatását vizsgáltuk. A témaválasztást a marketingkommunikációs eszköz újdonsága, érdekessége és folyamatos fejlődése indokolta amellett, hogy az online világnak köszönhetően alakult ki olyan kétirányú kommunikáció, mely további utakat nyitott meg a márkák és a fogyasztók között. Ehhez az új eszközhöz tartozik a közösségi média és az influencer marketing, amely a megjelenése óta népszerű és folyamatosan fejlődő terület. Kutatásunkban azt vizsgáltuk, hogy a megkérdezett reklámügynökségek, hogy látják az influencereket, hatással vannak-e a Z-generáció vásárlási szokásaira, mennyire megbízható termékeket hirdetnek és ezáltal mennyire tartják őket hitelesnek főleg, ha minden tartalmuk hirdetés. A tanulmányban a közösségi média és influencer marketing szakirodalmi áttekintése után kitérünk a Z-generáció bemutatására, akik a kutatás fókuszát adják. Ők azok a személyek, akik már a digitális világba születtek, számukra a felgyorsult világ szinte természetes. Elektronikus eszközeik nélkül nem léteznek, ebből következően állandóan jelen vannak az online világban, így kapták többek közt a bedrótozott nemzedék elnevezést is. Napjainkban számtalan közösségi platform létezik, melyek évről évre egyre sikeresebbek, hazánkban legkedveltebb platformok köz szerepel a YouTube, a Facebook, a Messenger, az Instagram és a TikTok. Ezeken az oldalakon futó marketingtevékenységek holisztikus elnevezése a közösségi média marketing, amely az összes közösségi oldalt magában foglalja, mégis minden felülete különbözik, hiszen minden oldalon más célközönséget lehet elérni, különböző kommunikációt használva. A tanulmány második felében a hazai influencer marketing jelenlegi helyzetéről készített kvalitatív kutatás eredményeit ismertetjük.
Örökerdő gazdálkodásban végzett gépesített fakitermelések hatásvizsgálata
Authors: Szakálosné Mátyás Katalin , Sudár Ferenc János
Published: July 2023

Az elmúlt évtizedekben megtöbbszöröződött a folyamatos erdőborítást biztosító örökerdő és átmeneti („örökerdőre átvezető”) üzemmóddal történő erdőkezelés, gazdálkodás, amelynek során a fákat egyesével, vagy csak kis csoportokban termelik ki, nagy figyelmet fordítva a talajra, visszamaradó fákra, újulatra. Mivel a fakitermeléseket szükségszerűen egyre inkább gépek segítségével kényszerül a szakma megvalósítani, időszerű vizsgálni ezen megoldások alkalmazhatóságát és környezetre gyakorolt hatásaikat. A mintaterületeken végrehajtott részletes mérések eredményei azt mutatják, hogy nem a gépesítettség fokától függ a károkozás mértéke, ha a körülményeknek megfelelően választjuk meg azokat és az alkalmazott munkarendszert.
Víz közvetett párolgásán alapuló, légszárítóval szerelt kísérleti levegőhűtő rendszer kialakítása laboratóriumi vizsgálatokhoz
Authors: Szaszák Norbert Tibor
Published: July 2023

Jelen tanulmányban egy olyan kísérleti léghűtő- és szárító rendszert mutatunk be, amely az elterjedt kompresszoros klímaberendezéstől várhatóan jóval alacsonyabb villamosenergia-igénnyel rendelkezik azonos hűtési teljesítmény esetén. A levegő hűtését olyan alacsony hőmérsékletű vizes sóoldat biztosítja, amely higroszkópos tulajdonsága révén a hűtéssel együtt a hűtött levegő abszolút páratartalmát is csökkenti. Az alacsony hőmérsékletű hűtő/szárító közeg előállításáért egy hőcserélő felel, amelyben a sóoldat a hőenergiáját hűtött lágyvíznek adja át. A lágyvíz hűtése egy evaporatív hűtőberendezésben, a lágyvíz külső környezetbe történő párologtatásával valósul meg. Így tehát a hűtendő levegőből elvont hő a vízpárában tárolt látens hővel a környezetbe távozik. A dolgozatban bemutatásra kerül a rendszer felépítése, továbbá az egyes rendszerelemek szerepe is. Részletesen kitérünk a hűtött vizet előállító evaporatív hűtőberendezés működésére, s annak fizikai megvalósítására is.
Reziliencia jelentősége a térség- és területfejlesztésben Borsod-Abaúj-Zemplén vármegyei minták bemutatásával
Authors: Bartók Balázs , Vasvári Mária
Published: July 2023

Munkánk a reziliencia vizsgálatát mutatja be Borsod-Abaúj-Zemplén vármegye esetében, Boldogkőváralja és Bódvalenke településeken. Elsősorban a rezilienciát, annak fogalmát, különböző területeken történő megjelenését elemeztük, így eljutva a térség- és területfejlesztésben betöltött szerepéhez. A cikk bemutatja, hogy a reziliencia a térség- és területfejlesztés milyen aspektusaiban számottevő, milyen lehetőségek vannak egy terület reziliens állapotú fejlesztésére. Mind a kettő mintaterület vagy azok szűkebb környezetére igaz, hogy a legfontosabb gazdaságfejlesztő tényező jelenleg a turizmus. A fejlődési folyamattal kapcsolatban a választott települések témában érintett szereplőit mélyinterjú segítségével kérdeztük meg. Így önkormányzati vezetőket, a helyi programokban érintett személyeket, és a helyi turizmusban érintett helyieket interjúztattunk meg, válaszaikat elemeztük. Ennek köszönhetően beleláthatunk, hogy a felvetett problémakör milyen módon jelenik meg a területen az egyes érdekképviseleti vezetők szemszögéből. A turizmusra vonatkoztatva pedig láthatjuk, hogy milyen jelentőséggel bírhat egy desztináció helyes vagy helytelen menedzsmentje, milyen hatással lehet egy terület életére, mennyire lehet gazdaságformáló tényező. Az interjúkérdések mind a két település esetében kitérnek a helyi lehetőségekre, erőségekre, a problémákra, a kockázati tényezőkre ezáltal lefedik a SWOT-analízis készítéséhez szükséges adatokat, rákérdezünk a célokra, a megvalósított tervekre, ezek hatékonyságára. A cikk kitér arra, hogy a területfejlesztésben fontos tényezők, mint az infrastruktúra, az elérhetőség milyen módon tehet reziliensé, vagy ezek hiányában kevésbé reziliensé egy adott települést. A turisztikai desztinációk esetében szintén jelentős a szuprastruktúra kiépítettsége, ami döntő lehet egy desztináció működésénél, erre szintén külön rákérdeztünk az interjúkon. A rezilienciára külön hangsúlyt fektettünk. Kíváncsiak voltunk válaszadóink mennyire vannak tisztában a fogalommal, milyen módon jelenik meg a település életében a reziliencia, mennyire foglalkoznak a kérdéskörrel. Mivel a reziliencia a negatív behatások elleni tűrőképességet jelenti, fontos, hogy a kérdéseinkre kapott válaszok eredményéből kiderítsük mit tartanak ilyen tényezőnek, valamint sikerült-e ezekkel a hatásokkal szemben fellépniük. Megjelentek-e a gazdaságformáló tényezők, s megindult-e a vidéki, periférikus területeken bármilyen fejlődési irány.
A felszín alatti hidrogéntárolás kihívásai az időszakos megújuló villamosenergia termelés egyensúlyozásában
Authors: Vadászi Marianna , Tomkóné Nyiri Katalin
Published: July 2023

A legújabb tudományos kutatások a szén-dioxid-mentes gazdaság előmozdítására irányulnak a megújuló energiaforrásokból származó villamos energia használata mellett. Bár a megújuló energiaforrások megoldást jelenthetnek a fosszilis tüzelőanyagokból származó antropogén üvegházhatású gázok kibocsátására, mégis szezonfüggőek, ezáltal az évente változó, de állandó energiakereslettel kombinálva a megújuló energia többletét vagy hiányát eredményezik. Ezért alapvető fontosságú egy hosszú távú tárolórendszer kidolgozása, amely egyensúlyba hozza időszakos keresletüket és kínálatukat. Cikkünkben bemutatjuk a hidrogén tárolótérre kifejtett hatásait, ismertetjük a földalatti tárolás formáit, amit a termeléshez kezdetben felhasznált energia, a végső elfogyasztott energia formája, az energiaátalakítási módszerek és ezen elemek kombinációi határoznak meg.
Városi tömegközlekedési járművek energiafogyasztása
Authors: Bodnár István
Published: July 2023

A tanulmány a városi tömegközlekedési járművek energiafogyasztását mutatja be. Kutatómunkám során azt vizsgáltam, hogy az egyes belső égésű motorral szerelt diesel és CNG üzemanyagú, valamint az elektromos meghajtású autóbuszok egymáshoz viszonyítva mekkora energiafelhasználással rendelkeznek. Az energiafogyasztás mellett számoltam az üzemanyag-költségekkel is.
Napelemes szünetmentes aszinkron motorhajtás szigetüzemű inverterrel
Authors: Boros Rafael Ruben , Bodnár István
Published: July 2023

A tanulmány egy szünetmentes aszinkron motoros hajtást mutat be, amely egy szigetüzemű napelem invertert is tartalmaz. A cikk kiemeli a két rendszer kombinálásának előnyeit és a szükséges rendszerelemeket. Ezenkívül bemutatja a teljes harmonikus torzítást és a működési paramétereket a különböző rendszertopológiákban. Az eredmények MATLAB szimuláció alapján jöttek lére.
Semantic Network is Completely Reconstructed
Authors: negi mohit , Kaushik Jatin , Dahiya Alok , Kaushik Deepak
Published: July 2023

Artificial Intelligence is a booming technology of the twenty-first century, and while it is still developing, thereis no disputing that it will continue to alter our way of life. Industry 4.0 is the name given to the currentindustrial age, which governs how the economy and development work. The four primary components ofIndustry 4.0 are: 1. computing power, 2. global communication, 3. big data, and 4. artificial intelligence. Oureffort aims to comprehend the fundamental mathematics of a basic Neural Network, often known as a Multi-Layer Perceptron (MLP). This paper can be useful for people who want to grasp the fundamental notions of aneural network by grasping the mathematics and key concepts that underpin it.
Qualitative sign stability of linear time invariant descriptor systems
Authors: Chand Madhusmita , Paitandi Mamoni , Gupta Mahendra Kumar
Published: July 2023

This article discusses assessing the instability of a continuous linear homogeneous timeinvariant descriptor system. Some necessary conditions and sufficient conditions are derived to establish the stability of a matrix pair by the fundamentals of qualitative ecological principles. The proposed conditions are derived using only the qualitative (sign) information of the matrix pair elements. Based on these conditions, the instability of a matrix pair can easily be determined, without any magnitude information of the matrix pair elements and without numerical eigenvalues calculations. With the proposed theory, Magnitude Dependent Stable, Magnitude Dependent Unstable, and Qualitative Sign Stable matrix pairs can be distinguished. The consequences of the proposed conditions and some illustrative examples are discussed.
Improving the energy efficiency of a tram’s running gear
Authors: Semenov Stanislav , Mikhailov Evgeny , Kliuiev Sergii , Dižo Ján , Blatnický Miroslav , Ishchuk Vadym
Published: July 2023

This research analyses the influence of some design features of an undercarriage of a tram on the energy efficiency in terms of mechanical energy losses during its operation. The work includes the comparison of results of the research from two main points of view, namely from a running gear design and a railway wheel design. Two variants of a tram’s bogie are investigated. A standard bogie and a bogie with a system that allows a radial adjustment of the wheelsets in curves. Two designs of a railway wheel are compared, a wheel with the traditional construction scheme and a wheel with a perspective construction scheme. The values of mechanical energy losses due to slippage in the contact between the wheels and rails are analysed. These losses are obtained with reference to a specific route and the value of the average power dissipated. Moreover, an analysis of advantages and disadvantages of bogie designs has made it possible to consider the most appropriate bogie design in terms of ensuring the energy efficiency. In this case, the bogie design with the wheels with the perspective construction scheme can be considered as the optimal option.
Ardagh Community Trust: transgressing boundaries, asserting community
Authors: Thomson Sam , Neuhaus Fabian , Franklin Alex , Robertson Natalie
Published: July 2023

Administrative boundaries are ubiquitous. A vital technology of power within the modern nation-state’s mode of bureaucratic governance, they carve up and abstract land and water alike into conceptual totalities that, in their simplification, render them legible to centralised administrative bodies. This is a foundational tool of state planning, the impact of which permeates all aspects of socio-economic life. These boundaries are not passive; they do not simply define a geographical area. Rather, they are selective in what they encompass and, as a result, what they include and exclude and what is rendered visible and, hence, valuable. This article describes an example of the real-world impact of this selectivity through discussion of the experiences of a community-led charity (Ardagh Community Trust) and the community group that founded it (Friends of Horfield Common). In their work to demonstrate that an administrative-boundary-spanning public green space (Horfield Common) and leisure facility (the Ardagh) was a vital community resource and hub, this article focuses on the work of Friends of Horfield Common/Ardagh Community Trust to ensure that their local community, one dissected by multiple administrative boundaries, was recognised and acknowledged when, in 2008, Bristol City Council in the UK proposed the sale of multiple publicly owned green spaces through their Parks and Green Space Strategy. Administrative boundaries played a key role in defining and determining which sites in the city were proposed for sale and in structuring the accompanying public consultation process, thereby determining which communities were recognised as communities in relation to this policy and, hence, which communities’ opinions were actively sought and heard. This article concludes by highlighting some of the potential political and economic costs attendant on reifying administrative boundaries rather than lived communities in both planning and consultation processes.
Artisanal fishery with surface gillnets and megafauna strandings
Authors: Mayra Jankowsky , Martins Ivan Machado , Prado Deborah Santos , Mendonça Jocemar Tomasino
Published: July 2023

Bycatch is an issue of worldwide relevance involving conflicts between conservation and fishery interests. In Brazil, this conflict has been highlighted in relation to the regulation of small-scale fishery with surface gillnets. To promote management and transformation of this conflict, we analyzed the relationship between catch unloadings from small-scale fishing with surface gillnets and strandings of marine megafauna. We used fishery monitoring data and beach monitoring data in São Paulo between 2015 and 2021, relating to Chelonia mydas, Caretta caretta, Lepidochelys olivacea, Pontoporia blainvillei and Sotalia guianensis. The analyses included (i) overview of catches unloadings from small-scale fishing with surface gillnets and strandings that resulted in the death of each of these species over the course of the year; (ii) correlation tests between those variables for the northern, central, and southern regions; and (iii) performing regression analyses for municipalities within these regions, exhibiting statistically significant positive correlations. The fisheries harvest period was found not to overlap with the stranding distribution. In correlation tests, only strandings of C. mydas in the northern and southern regions, S. guianensis in the southern region and P. blainvillei in the central region showed relationships with fishing landings. The regression analysis was significant for C. mydas and S. guianensis. At the municipal level, the results were statistically significant for C. mydas in São Sebastião, Ubatuba, Ilha Comprida and Cananéia and for S. guianensis in Cananéia. However, the regression explained a small part of the mortality and other impact factors were pointed out. Non-prohibitive management measures, participatory studies, and direct methods for evaluating the interaction between fisheries and megafauna associated with environmental factors should be implemented, along with analyses on other impacts on megafauna.
O Fogo nas Savanas e seu Impacto na Avifauna: Considerações para uma Melhor Conservação Ambiental
Authors: Nunes Bárbara Beatriz da Silva
Published: July 2023

As savanas são um bioma pirofítico, hotspot de biodiversidade e de relevante importância mundial, ocupando 20% da superfície terrestre. É um bioma que necessita da queima para a manutenção da sua biodiversidade e pirodiversidade, tendo sofrido com a alteração dos regimes de fogo pela ação conjunta direta e indireta de fatores como desmatamento, agropecuária e mudanças climáticas, resultando na perda, degradação e fragmentação de hábitats. Tal fato pode gerar impactos para a avifauna, alterando dinâmicas populacionais e sua distribuição na paisagem. Assim, esse trabalho avaliou quais as influências do fogo em populações de avifauna nas savanas, por meio de uma pesquisa bibliográfica. Constatou-se que o fogo impacta a avifauna diretamente ou indiretamente, bem como atuam positivamente ou negativamente, conforme o nicho da espécie avaliada e suas características intrínsecas. O efeito observado dependerá da capacidade de detecção de incêndios, capacidade de locomoção, espécie, hábito, guilda funcional, parâmetros demográficos, disponibilidade de recursos, evolução sucessional pós-distúrbio, habilidade de dispersão e a escala geográfica da área atingida pelo incêndio. Os principais impactos observados para esse clado são os efeitos indiretos, sendo que suas populações mais impactadas negativamente são as ratitas e as que tem baixa capacidade de locomoção. Apesar das muitas lacunas de conhecimento acerca dos efeitos do fogo sobre parâmetros populacionais da avifauna, os estudos que enfocam dinâmicas de comunidades indicam que, no geral, há poucas alterações nos índices de riqueza e abundância. Assim, faz-se necessária uma maior compreensão sobre as consequências do fogo sobre as aves, para subsidiar melhor as ações do Programa de Manejo Integrado do Fogo e a sua ampliação no território brasileiro, em busca de uma gestão ambiental de qualidade, dinâmica e integrada.
Sustainability attitudes in nursing survey: A cross-cultural adaptation and validation study
Authors: İLASLAN Nagihan , Şahin Orak Nuray
Published: July 2023

Research aim: The aim of this study was to cross-culturally adapt the Sustainability Attitudes in Nursing Survey into Turkish and evaluate its validity and reliability among Turkish speaking nursing students.
Methods: This methodological study was conducted with 400 nursing students, selected using a simple random sampling method from students studying at a state university in Turkey. Sociodemographic Characteristics Questionnaire and Sustainability Attitudes in Nursing Survey were used for data collection. The linguistic content validity analysis and Confirmatory Factor Analysis were performed to determine the validity of the survey. Test-retest reliability and Cronbach Alpha coefficient were determined for reliability of the survey.
Findings: The Content Validity Index of the Turkish version of the Sustainability Attitudes in Nursing Survey was found to be 0.91. In the Confirmatory Factor Analysis, the survey was confirmed as a single-factor model. The Cronbach Alpha coefficient of the survey was determined to be 0.76 and the intra-class correlation was 0.81 as a result of the test-retest.
Conclusions: The Turkish version of the survey has sufficient validity and reliability to evaluate sustainability attitudes of nursing students in the Turkish culture. It is recommended to conduct international comparative studies to identify nursing students’ sustainablity attitudes.