bluuebunny/crossref_metadata_2025 huggingface dataset:
Patient Acceptability of Telehealth Medication Abortion Care in the United States, 2021‒2022: A Cohort Study
Authors: Koenig Leah R. , Ko Jennifer , Valladares Ena Suseth , Coeytaux Francine M. , Wells Elisa , Lyles Courtney R. , Upadhyay Ushma D.
Published: January 2024

Objectives. Despite the recent expansion of direct-to-patient telehealth abortion care in the United States, patient experiences with the service are not well understood.

Methods. We described care experiences of 1600 telehealth abortion patients in 2021 to 2022 and used logistic regression to explore differences by race or ethnicity and between synchronous (phone or video) and asynchronous (secure messaging) telehealth abortion care.

Results. Most patients trusted the provider (98%), felt telehealth was the right decision (96%), felt cared for (92%), and were very satisfied (89%). Patients most commonly cited privacy (76%), timeliness (74%), and staying at home (71%) as benefits. The most commonly reported drawback was initial uncertainty about whether the service was legitimate (38%). Asian patients were less likely to be very satisfied than White patients (79% vs 90%; P = .008). Acceptability was high for both synchronous and asynchronous care.

Conclusions. Telehealth abortion care is highly acceptable, and benefits include privacy and expediency.

Public Health Implications. Telehealth abortion can expand abortion access in an increasingly restricted landscape while maintaining patient-centered care. ( Am J Public Health. 2024;114(2):241–250. https://doi.org/10.2105/AJPH.2023.307437 )
PERFORMANSI ALAT PENGASAPAN IKAN DENGAN SISTEM ROTARI HORIZONTAL
Authors: Perdana Mastariyanto , Hafni Hafni , Yulianti Lusi , Romi Romi , Alfith Alfith , Pratiwi Putri , Nurzal Nurzal
Published: January 2024

Salah satu teknik pengawetan ikan yang sangat banyak dimanfaatkan pada saat ini adalah teknik pengasapan. Pada umumnya proses pengasapan ikan masih secara tradisional dan menggunakan oven konvensional. Metode tersebut merupakan cara yang mudah untuk melakukan pengasapan ikan. Tujuan penelitian ini adalah untuk mengetahui efisiensi alat pengasapan ikan dengan menggunakan sistem rotari horizontal. Alat pengasapan ikan ini terdiri dari ruang pengasapan, tungku pembakaran, dudukan lele sistem rotari, motor DC, roda gigi, dan rantai. Kapasitas alat pengasapan ikan system rotari ini adalah 9 kg ikan basah. Ikan yang digunakan pada penelitian ini adalah ikan lele dan ikan cakalang. Pengasapan ini menggunakan hasil dari pembakaran kayu kulit manis. Kayu kulit manis akan menghasilkan asap yang berguna untuk pengasapan ikan. Berat ikan basah dalam satu kali pengasapan pada penelitian ini adalah 8 Kg. Metode pengasapan mempunyai standar perbandingan berat ikan basah dan berat ikan kering sebesar 4:1. Untuk pengasapan ikan lele, setelah dilakukan pengasapan selama 2 jam dengan temperatur 80 oC – 90 oC, berat ikan lele menjadi 2 kg. Untuk pengasapan ikan cakalang, setelah dilakukan pengasapan selama 2,5 jam dengan temperatur 80 oC – 90 oC, berat ikan cakalang menjadi 2 kg.  Dari hasil pengujian, dapat disimpulkan bahwa alat pengasapan ikan dengan sistem rotari sangat bagus untuk digunakan sebagai alat pengasapan ikan karena memiliki efisiensi yang cukup tinggi dibandingkan dengan alat tradisional seperti oven dimana metode pengasapan tradisional membutuhkan waktu selama 36 jam dan metode pengasapan sistem oven membutuhkan waktu selama 12 jam.
Yang Melakukan Akan Dikenang Pengalaman Mahasiswa Di Desa Nogosari Kecamatan Pandaan
Authors: Maryanti Eny
Published: January 2024

Rasa syukur selalu tercurah kepada Allah SWT yang senantiasa melimpahkan rahmat, hidayah serta kesehatan, sehingga kami dapat melaksanakan program Kuliah Kerja Nyata Pencerahan (KKN-P) Universitas Muhammadiyah Sidoarjo tahun 2020. Kuliah Kerja Nyata (KKN) adalah program yang ditempuh mahasiswa Universitas Muhammadiyah Sidoarjo merupakan perwujudan dari salah satu Catur Dharma Perguruan Tinggi, yaitu bermaksud memberikan pengalaman secara langsung baik fisik maupu mental kepada calon sarjana dengan terjun bersama masyarakat dengan menerapkan ilmu jurusan masing-masing. Didalam KKN-P 2020 Universitas Muhammadiyah Sidoarjo, lokasi kegiatan di Desa Nogosari, Kecamatan Pandaan, Kabupaten Pasuruan. Dalam topik garapan kegiatan ini ialah mensosialisasikan kepada seluruh warga Desa Nogosari tentang Bank Sampah dan pemilahan sampah basah dan sampah kering. Dan juga mendampingi proses pembuatan laporan keuangan BUMDES.
Impulsionadores e Restritores à Participação na Coleta Seletiva Residencial de Resíduos Sólidos Urbanos
Authors: Silva Leandro Moura da , Pinto Francisco Roberto , Gerhard Felipe , Roberto Felipe
Published: January 2024

Contextualização: O número de municípios que disponibilizam programas de coleta seletiva está aumentando no Brasil. No entanto, observa-se que uma grande quantidade de materiais recicláveis é destinada indevidamente a aterros sanitários, evidenciando a baixa efetividade dos programas de coleta seletiva. Este fato é ocasionado pela baixa adesão popular aos programas de coleta seletiva.

Objetivo: com base nessa problemática, a presente pesquisa teve por objetivo identificar os fatores que impulsionam e que restringem a participação popular em programas de coleta seletiva.

Enquadramento Teórico: foi proposto um modelo teórico para identificar quais fatores influenciam a participação popular em programas de coleta seletiva.

Metodologia: O estudo de campo consiste em uma pesquisa de natureza quantitativa, realizada com residentes de uma grande capital brasileira, com a aplicação de questionário de forma presencial e on-line. Os dados coletados foram submetidos à análise descritiva, análise fatorial confirmatória e Modelagem de Equações Estruturais.

Resultados: As hipóteses levantadas foram aceitas e seus resultados confrontados com a teoria expressa. Os resultados permitiram identificar a existência de fatores que impulsionam e que restringem a participação popular em programas de coleta seletiva. Apesar de algumas limitações, vale ressaltar que os objetivos foram alcançados.

Originalidade: Esta pesquisa inova por empregar uma metodologia, de natureza quantitativa, com técnicas robustas de análise multivariada e Modelagem de Equações Estruturais para apoiar os aspectos teóricos originais.

Contribuições teóricas e práticas: Os achados dessa pesquisa podem mudar a forma como são definidas as estratégias de divulgação e operacionalização dos programas de coleta seletiva. Outro ponto relevante refere-se à educação formal e social, já que o estudo apontou que esses motivos também não foram capazes de influenciar a participação popular em programas de coleta seletiva.
Effects of Changes in Internet Information Service Use Rates on Life Satisfaction of Older Adults during the COVID-19 Pandemic
Authors: Park Eun-Young , Kim Jung-Hee
Published: January 2024

Backgroud : It is helpful to identify factors, such as optimistic attitudes or feelings of control, that protect against the negative mental health burdens of a pandemic. The COVID-19 pandemic crisis has motivated some older people to adopt new technologies to simplify their chores and to provide a powerful defense against loneliness and social isolation. The purpose of this study was to assess the effects of changes in Internet information service use rates on the life satisfaction of older adults after the COVID-19 pandemic. Methods : This study analyzed data from the digital divide information survey by the National Information Society Agency (NIS) in 2020. The age criterion was set at 65 years or older, resulting in 1150 data points that were analyzed. A multivariate linear regression was conducted to investigate the associations of age, education level, employment, and income with changes in the seven categories of the Internet information service use rate. Resuts : Income (β = 0.146, p < 0.001) significantly affected life satisfaction of older adults. A high income was associated with high life satisfaction. Among changes in Internet information service use rate, increased SNS (β = 0.127, p < 0.001) and digital consumption (β = 0.074, p = 0.048) were significantly associated with greater life satisfaction. Conclusion : It is important to encourage older adults to use digital device to stay in touch with loved ones and friends and to take part in person-centered activity programs that are both safe and accessible. To this end, policymakers should offer public assistance to older adults to use Internet and mobile applications technologies.
Workforce outcomes among substance use peer supports and their contextual determinants: A scoping review protocol
Authors: Bell Justin S. , Griffin Tina , de Martell Sierra Castedo , Kay Emma Sophia , Hawk Mary , Ray Bradley , Watson Dennis
Published: January 2024

Background
Peer recovery support services are a promising approach for improving harm reduction, treatment, and recovery-related outcomes for people who have substance use disorders. However, unique difficulties associated with the role may put peer recovery support staff (i.e., peers) at high risk for negative workforce outcomes, including burnout, vicarious trauma, and compassion fatigue, which impact one’s personal recovery journey. Little is known about the extent to which peers experience such negative outcomes or the influence the service setting context has upon them. This scoping review aims to describe the nature and extent of research evidence on peers’ workforce outcomes and how these outcomes might differ across service settings.
Methods
A scoping review will be conducted with literature searches conducted in PsycINFO®, (EBSCO), Embase® (EBSCO), CINAHL® (EBSCO), Web of Science™ (Clarivate), and Google Scholar databases for relevant articles discussing US-based research and published in English from 1 January 1999 to 1 August 2023. The study will include peer-reviewed and grey-literature published materials describing the experiences of peers participating in recovery support services and harm reduction efforts across a variety of service settings. Two evaluators will independently review the abstracts and full-text articles. We will perform a narrative synthesis, summarizing and comparing the results across service settings.
Conclusions
This review will assess the state of the literature on peer workforce-related outcomes and how outcomes might vary by service setting context. Exploration will include individual characteristics of peers that moderate workforce outcomes, and workforce outcomes that mediate personal recovery outcomes. Results will inform the field regarding future directions for research in this area.
Systematic review registration
Submitted to Open Science Framework, August 22nd, 2023.
Locating Scheme Planning Algorithm based on Positioning Normal Line and Analytical Hierarchy Process
Authors: Zhang Duo , Wang Youli , Wang Xiaohui , Guo Jiacheng
Published: January 2024

Planning methods tailored for individual stages of locating schemes often fall short of achieving overall optimization. Therefore, by employing the positioning normal line as a medium and based on the geometric theorem of workpiece locating concerning the positioning normal line, the relationship between workpiece degrees of freedom and the positioning normal line can be deduced. This enables the acquisition of positioning normal line information for the freedom constraint model, consequently deriving an initial layout for the locating points. This initial layout sieves through all surfaces of the workpiece, establishing a set of candidate locating references. The intrinsic conditions of the workpiece surfaces, alongside the corresponding clamping surface quality, are utilized as measures to gauge their locating capabilities. Aiming for optimal locating capabilities, the Analytic Hierarchy Process (AHP) is employed to ascertain a comprehensive, optimal vector encompassing the combined locating capabilities of various workpiece surfaces, aiding in the selection of locating references. The feasibility of this method is validated through practical examples. Results demonstrate that the layout of locating points planned using this method, in conjunction with the positioning normal information provided by different characteristic types as summarized in this paper, effectively guides machining personnel in formulating locating schemes.
Classification and counting of cells in brightfield microscopy images: an application of Convolutional Neural Networks
Authors: Ferreira E. K. G. D. , Silveira Guilherme
Published: January 2024

Microscopy is integral to medical research, facilitating the exploration of various biological questions, notably cell quantification. However, this process's time-consuming and error-prone nature, attributed to human intervention or automated methods usually applied to fluorescent images, presents challenges. In response, machine learning algorithms have been integrated into microscopy, automating tasks and constructing predictive models from vast datasets. These models adeptly learn representations for object detection, image segmentation, and target classification. An advantageous strategy involves utilizing unstained images, preserving cell integrity and enabling morphology-based classification—something hindered when fluorescent markers are used. The aim is to introduce a model proficient in classifying distinct cell lineages in digital contrast microscopy images. Additionally, the goal is to create a predictive model identifying lineage and determining optimal quantification of cell numbers. Employing a CNN machine learning algorithm, a classification model predicting cellular lineage achieved a remarkable accuracy of 93%, with ROC curve results nearing 1.0, showcasing robust performance. However, some lineages, namely SH-SY5Y (78%), HUH7_mayv (85%), and A549 (88%), exhibited slightly lower accuracies. These outcomes not only underscore the model's quality but also emphasize CNNs' potential in addressing the inherent complexities of microscopic images
The Treatment of diarrheal mice with Tenebrio Molitor meal
Authors: Liu Tingting , Wang Qiaoli , Wang Zhengli , Yan Jiaxu , zhu jian jun , wang Jungang
Published: January 2024

Feeding Tenebrio Molitor meal has an important effect on promoting the growth, absorption, reproduction, and disease resistance of animals. In this study, 3×108cfu/ml Escherichia coli was used to establish a mouse diarrhea model. Different doses (8%, 5%, 2.5%) of tenebrio molitor meal were added to the basic diet, respectively. The feed intake, water intake, body weight, loose stool rate, diarrhea rate, intestinal flora number, immune organ index, intestinal enzyme, and serum enzyme activities of the diarrhea mice were detected. The results showed that compared with the model group, the feed intake, water intake, and body weight of mice with diarrhea were improved by adding tenebrio molitor meal, and the dosage was proportional to that of tenebrio molitor meal. The rate of loose stool and diarrhea decreased with the increase of tenebrio molitor meal. The total bacterial count and Escherichia coli count in the intestinal tract of mice with diarrhea were negatively correlated with the dosage of tenebrio molitor meal. The immune organ index of the diarrhea mice in the three tenebrio molitor meal supplementation groups was higher than that in the model group and was proportional to the dosage. The liver index of the 8% tenebrio molitor meal supplementation group was 11.79mg/g higher than that in the blank group. Compared with the blank group, diarrhea significantly decreased the activities of various enzymes in the intestinal tract and serum of mice (P < 0.05). Compared with the model group, the activities of intestinal and serum protective enzymes (superoxide dismutase, peroxidase, catalase), detoxification enzymes (glutathione-S transferase, acetylcholinesterase, acid phosphatase) and digestive enzymes (serum amylase, serum lipase, lactate dehydrogenase) in diarrhea mice were increased by adding tenebrio molitor meal (P < 0.05). The results showed that tenebrio molitor meal had a positive effect on the treatment of diarrhea in mice.
LLamol: A Dynamic Multi-Conditional Generative Transformer for De Novo Molecular Design
Authors: Dobberstein Niklas David , Maass Astrid , Hamaekers Jan
Published: January 2024

Generative models have demonstrated substantial promise in Natural Language Processing (NLP) and have found application in designing molecules, as seen in General Pretrained Transformer (GPT) models. In our efforts to develop such a tool for exploring the organic chemical space in search of potentially electro-active compounds, we present LLamol, a single novel generative transformer model based on the LLama 2 architecture, which was trained on a 13M superset of organic compounds drawn from diverse public sources. To allow for a maximum flexibility in usage and robustness in view of potentially incomplete data, we introduce Stochastic Context Learning as a new training procedure. We demonstrate that the resulting model adeptly handles single- and multi-conditional organic molecule generation with up to four conditions, yet more are possible. The model generates valid molecular structures in SMILES notation while flexibly incorporating three numerical and/or one token sequence into the generative process, just as requested. The generated compounds are very satisfactory in all scenarios tested. In detail, we showcase the model's capability to utilize token sequences for conditioning, either individually or in combination with numerical properties, making LLamol a potent tool for de novo molecule design, easily expandable with new properties.
Scientific Contribution: We developed a novel generative transformer model, LLamol, based on the LLama 2 architecture that was trained on a diverse set of 13M organic compounds. It introduces Stochastic Context Learning (SCL) as a new training procedure, allowing for flexible and robust generation of valid organic molecules with up to multiple conditions that can be combined in various ways, making it a potent tool for de novo molecular design.
The Effect of State and Trait Anxiety on Pain-Pressure Threshold
Authors: Lowe Scott , Downing Katelyn , Fair Breana , Hughey Christian
Published: January 2024

Background:
The global burden of persistent pain is substantial, affecting up to 30% of the world's population. Despite growing awareness, challenges persist with accurate pain measurement, limiting research and clinical efforts. One method to assess pain perception is the Pain-Pressure Threshold (PPT), indicating the pressure at which pain is reported. Anxiety, comprising state and trait anxiety, has been suggested as a potential influencer of PPT, yet its precise impact remains uncertain. State anxiety is defined as a "transient state of arousal subjectively experienced as anxiety" Trait anxiety is “an individual's tendency to appraise situations as threatening, avoid anxiety-provoking situations, and demonstrate high baseline physiological arousal”
Methods:
Thirty-eight participants with no history of persistent pain or anxiety completed data collection, 19 men and 19 women, ages 22-32. Subjects completed the State-Trait Anxiety Inventory-5 (STAI-5) and underwent PPT testing at the upper trapezius and forearm extensors bilaterally, with results averaged to provide an extrapolation of global pressure tolerance. The same data was collected again 21 days later.
Results:
No correlation existed between anxiety and PPT. No significant correlation (p=.148) was observed in State anxiety scores between baseline and follow-up, while trait anxiety displayed a moderate relationship (r=.612, p<.001) between the initial and subsequent tests. These findings support the notion that state anxiety is more variable, contrasting with the presumed stability of trait anxiety. Pain-pressure threshold test-retest data revealed a moderate relationship (r=.542, p<.001), consistent with prior research on PPT test reliability.
Discussion/Conclusion:
This research is unique in that we assessed the relationship between anxiety and PPT in young, healthy participants. The principal finding is that pain-pressure thresholds were not shown to be influenced by either trait or state anxiety in our sample. The data also provided further information about the test-retest consistency of the STAI-5 and PPT measures. This research provides initial baseline data, against which findings in other populations can be compared. Future research should continue to aim to quantify psychosocial factors and their influence on pain experiences.
Trial Registration: This study was registered on 21/09/2023 on ClinicalTrials.gov: # NCT06047704
Glutamine Deprivation Suppresses Lung Cancer Metastasis via Inducing the Activation of ZAKα and Translation Inhibition
Authors: Lei Yinrui , Lin Huiyun , Liu Peiyan , Guo Fang
Published: January 2024

Background
Amino acids are not only components of proteins, but also play important roles in many cellular processes, such as regulating the mTORC1 activity, controlling the translation. However, the role of each amino acid on lung cancer metastasis is still uncertain.
Methods
Transwell assays were used to detect to migration and invasion of cancer cells. Real Time PCR was used to detect the transcription of genes. RNA-seq was performed to analyze the signature of EMT-related genes. Western blot was used to detect the level of proteins. Phospho-gel was used to detect the activation of ZAKα. Puromycin incorporation assay was conducted to show the extent of translation. Lentivirus packaging was used to construct stable cell lines. Mutagenesis was conducted to mimic the dominant-negative or activation of proteins. Mouse lung seeding was used to detect the metastasis of tumor cells in vivo.
Results
Here, we found that, among the 20 basic amino acids, glutamine deprivation specifically inhibits EMT, migration and invasion of lung cancer cells. While, this effect of glutamine is independent of its metabolism. Mechanistically, we found that glutamine promotes A549 cell migration and invasion by enhancing the translation of Zeb1 and Snail. The phosphorylation of translation factors: eIF2α S51, eIF4E S209 and eEF2 S57 induced by glutamine limitation is dispensable for the translation of Zeb1 and Snail. Further, glutamine deprivation dramatically activates ZAKα and its substrates JNK and p38. Knockdown of ZAKα rescues lung cancer cell migration and invasion under glutamine deprivation, while constitutive activation of ZAKα W347S or F368C inhibits lung cancer cell migration and invasion in the presence of glutamine. In mouse models, ZAKα W347S or F368C inhibits the lung seeding of A549 cells.
Conclusions
Glutamine depletion could activate ZAKα to inhibit the translation of EMT-TFs and thus suppress the lung cancer cell metastasis. Our findings uncover the special effect of glutamine on the regulation of translation and lung cancer metastasis, which may give us a new insight into nutrient and cell fate during lung cancer development.
Polyaniline/SiO2 Nanocomposite Catalyzed One-pot Three Component Synthesis of 3,4-dihydropyrimidin-2(1H)-one Derivatives
Authors: Yelwande Ajeet A. , Navgire Madhukar E. , Tayde Deepak T. , Lande Machhindra K.
Published: January 2024

An efficient and rapid protocol for the synthesis of one-pot 3,4-dihydropyrimidin-2(1H)-ones has been developed by the polyaniline/SiO2 catalyzed condensation of benzaldehydes, β-ketoesters and urea/ thiourea. Polyaniline/SiO2 nanocomposite was synthesized by chemical oxidative polymerization of aniline monomer on the surface of SiO2 in the presence potassium persulphate (K2S2O8) as oxidizing agent and sulfuric acid (H2SO4).The synthesized catalytic materials have been well characterized by means of transmission electron microscopy (TEM), thermal analysis (TG-DTA), X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), Temperature programmed desorption (NH3-TPD) and Brunauer Emmett and Teller (BET) method. Solvent stability of catalyst was tested using UV-Visible spectroscopy. Thermal stability of Polyaniline is noticeably improved which may due to the insertion of polyaniline on the surface of SiO2. NH3-TPD was used to determine the acidic properties of solid catalyst Polyaniline/SiO2 indicate the weak, medium and strong acidic sites total acidic strength is found to be 0.2906 mmol/gm. The specific surface area and average pore diameter of 10 wt % polyaniline/SiO2 are found 75.3443 m²/g and 10.8823 nm. This protocol has several advantages such as good thermal stability, high yield, simple work up procedure, non-toxic, clean, and easy recovery and reusability of the catalyst system.
Investigation of physio-mechanical, antioxidant and antimicrobial properties of starch- zinc oxide nanoparticles active films reinforced with Ferula gummosa Boiss essential oil
Authors: Sarhadi Hamid , Shahdadi Fatemeh , Sardoei Ali Salehi , Hatami Mehrnaz , Ghorbanpour Mansour
Published: January 2024

The production of surface compounds coated with active substances has attracted a lot of attention in recent years. In this study, the physical, mechanical, antioxidant, and antimicrobial properties of starch/zinc oxide nanoparticles (ZnO NPs) composite containing various concentrations of Ferula gummosa Boiss essential oil (0.5, 1 and 1.5%) were investigated. The addition of ZnO NPs improved the thickness, and the mechanical and microbial properties, and on the other hand, reduced the water vapor permeability of the starch active film. The addition of Ferula gummosa Boiss essential oil to starch nanocomposite decreased the water vapor permeability from 6.25 to 5.63 g mm− 2 d− 1 kPa− 1, but this decrease was significant only in the concentration of 1.5% of essential oils (p < 0.05). The addition of essential oil to starch nanocomposite caused a decrease in Tensile Strength (TS) value and an increase in Elongation at Break (EB) values was obtained by adding 1.5% of Ferula gummosa Boiss essential oil to starch. The results of the antimicrobial activity of the nanocomposite showed that the pure starch film did not show any lack of growth zone. The addition of ZnO NPs to the starch matrix caused antimicrobial activity on both studied bacteria (Staphylococcus aureus, Escherichia coli). The highest antimicrobial activity was observed in the starch/ ZnO NPs film containing 1.5% essential oil with an inhibition zone of 340 mm2 on Staphylococcus aureus. Antioxidant activity increased significantly with increasing concentration of Ferula gummosa Boiss essential oil (P < 0.05). The film containing 1.5% essential oil had the highest (50.5%) antioxidant activity. In this study, the effect of starch/ ZnO NPs composite containing Ferula gummosa Boiss essential oil was also investigated in order to increase the shelf life of rainbow salmon fillets. Microbial load, lactic acid bacteria and psychrophilic bacteria of salmon fillets were reduced by coating. Coating also improved the chemical characteristics of fish fillet. In general, the starch nanocomposite containing ZnO NPs and Ferula gummosa Boiss essential oil has the ability to be used in the aquatic packaging industry.
Morbidity and neurodevelopmental outcomes at 2 years in preterm infants undergoing percutaneous transcatheter closure vs. surgical ligation of the PDA
Authors: Ramos Maria Fernandez , Reichlin Amy , Kase Jordan , Giamelli Joseph
Published: January 2024

Objective: Review a cohort of preterm infants <29 weeks of gestation at birth and compare morbidities and neurodevelopmental outcomes based on type of PDA closure.
Study design: Single center observational retrospective-prospective case control study of premature infants who underwent surgical ligation or percutaneous transcatheter closure of the PDA. Neurodevelopmental testing was done using the Bayley Scales of Infant Development 3rd ed.
Results: The percutaneous transcatheter closure group had an older corrected gestational age and weight at the time of procedure, and started enteral feeds and achieved room air status at an earlier post procedure day. Infants in the surgical ligation group were more likely to experience vocal cord paralysis. There was no difference in neurodevelopmental outcomes between groups.
Conclusion: Waiting for infants to achieve the appropriate size for percutaneous transcatheter closure of the PDA may lead to reduced short-term complications without increasing the risk of neurodevelopmental impairment.
Comparison of the Myopia Control Effectiveness and Defocus of OK and HAL in Adolescents
Authors: Yu Jia , Guo Yujuan , Zhou Yuehua
Published: January 2024

Purpose
To compare the control effectiveness and periretinal defocus between orthokeratology(OK) and highly aspherical lenslets(HAL) in adolescents with myopia.
Methods
In this prospective study, 211 children( 211 eyes) were enrolled in Beijing Ming Vision and Ophthalmology between October 2022 and February 2023. According to the myopic correction method, the children were divided into three subgroups: OK, HAL, and Single-Vision spectacles (SVS); according to the spherical equivalent (SE), they were further divided into two subgroups: A-1.0 ≤ SE≤-2.0D, B-2.0<SE≤-3.0 D.All children were followed up for12mo,and the changes in axial length and periretinal defocus before and after treatment were recorded and the factors affecting the corneal shaping force for one day post-OK were analyzed.
Results
AL growth in the OK and HAL was lower than that in the SVS after 6,9,12mo. Comparison of the difference in the amount of AL change between OK and HAL: 6mo( Z=-1.367 ,P = 0.317) ; 9mo(Z=-1.45, P = 0.211) ;12mo( Z=-1.52, P = 0.365 ), the difference was not statistically significant with (-1.0 ≤ SE≤-2.0D). The myopic defocus of RDV270-300° in the HAL subgroup was higher than that in the OK subgroup(Z = 1.382,P = 0.016),and in other areas,the myopic defocus was higher in the OK subgroup. Em,SRI ,and corneal thickness were significantly associated with shaping force.
Conclusions
OK is one of the most effective optical treatments for controlling myopia and the factors that affect the corneal shaping force under different corneal parameters are different.For mild myopia, HAL can achieve the same effectiveness as OK.
A Deep Dive into GI Tract Imaging Transformation through Advanced Image Segmentation Analysis with Deep Learning
Authors: Vidyullatha Pellakuri , Tirumala Sreeram , PVL Madhav , Sai Pavan , Vivek Manda DVSSRK , Ghantasala G S Pradeep , Allabun Sarah , ELSHIEKH E. , Othman Manal , Abbas Mohamed , Soufiene Ben Othman
Published: January 2024

The reconstruction of computed gastrointestinal tract tomography images has been a vibrant field of study, particularly with the emergence of deep learning techniques. These methods leverage data-driven models to enhance the quality of reconstructions. Our research delves into this domain by conducting a comprehensive data challenge, where various deep learning algorithms were assessed using extensive public datasets. The focal point was on quantitatively evaluating these methods. A noticeable outcome of our investigation is the substantial enhancement in reconstruction quality metrics achieved by deep learning-based approaches, both in applications involving computed tomography (CT) and using methods such as Region-CNN (RCNN) and Conditional Invertible Neural Networks (CINN). We also delve into crucial selection criteria for these methods, encompassing factors like the availability of training data, understanding the physical measurement model, and the speed of reconstruction. The prevailing technique for segmenting three-dimensional tract images relies on convolutional networks and Conditional Invertible Neural Networks. Yet, these advanced architectures, including CNN, RNN, and CINN, impose heavy computational demands, necessitating GPU-accelerated workstations for rapid inference. This research work introduces a novel segmentation method employing a human-like strategy for 3D segmentation where initially analyzes the image at a small scale to pinpoint areas of interest, subsequently processing only pertinent feature-map patches. This innovation drastically reduces inference time and all while upholding state-of-the-art segmentation quality.
Key gene modules and hub genes associated with pyrethroid and organophosphate resistance in Anopheles mosquitoes: A systems biology approach
Authors: Odhiambo Cynthia Awuor , Derilus Dieunel , Impoinvil Lucy Mackenzie , Omoke Diana , Saizonou Helga , Okeyo Stephen , Dada Nsa , Mulder Nicola , Nyamai Dorothy , Nyanjom Steven , Lenhart Audrey , Djogbénou Luc , Ochomo Eric
Published: January 2024

Indoor residual spraying (IRS) and insecticide-treated nets (ITNs) are the main methods used to control mosquito populations for malaria prevention. The efficacy of these strategies is threatened by the spread of insecticide resistance (IR), limiting the success of malaria control. Studies of the genetic evolution leading to insecticide resistance could enable the identification of molecular markers that can be used for IR surveillance and an improved understanding of the molecular mechanisms associated with IR. This study used a weighted gene co-expression network analysis (WGCNA) algorithm, a systems biology approach, to identify genes with similar co-expression patterns (modules) and hub genes that are potential molecular markers for insecticide resistance surveillance in Kenya and Benin. A total of 20 and 26 gene co-expression modules were identified via the average linkage hierarchical clustering from Anopheles arabiensis and An. gambiae, respectively, and hub genes (highly connected genes) identified within each module. Four specific genes stood out: serine protease, E3 ubiquitin-protein ligase, cuticular protein RR2, and leucine-rich immune protein, which were top hub genes in both species and could serve as potential markers and targets for monitoring IR in these malaria vectors. In addition to the identified markers, we explored molecular mechanisms using enrichment maps that revealed a complex process involving multiple steps, from odorant binding and neuronal signaling to cellular responses, immune modulation, cellular metabolism, and gene regulation. Incorporation of these dynamics into the development of new insecticides and tracking of insecticide resistance could improve sustainable and cost-effective deployment of interventions.
The impact of college enrollment expansion policy on income gap: a case study from China
Authors: HUANG Yutong , DUAN Jinghui
Published: January 2024

This study focuses on the empirical research on the impact of college enrollment expansion policy on the income gap of residents. In this paper, the distribution characteristics of the sample survey data of residents’ income before and after the college enrollment expansion policy (1989–2015) in China Health and Nutrition Survey Database (CHNS) are firstly investigated. And the counterfactual analysis of the income gap of residents before and after the college enrollment expansion policy is conducted by using Recentered Influence Function (RIF) regression modeling and Firpo Fortin Lemieux (2009) (FFL) decomposition method respectively. The results show that: (1) The income gap of residents before and after the college enrollment expansion policy is the result of the combined effect of the “effect of returns to education” and the “effect of labor structure”. The “effect of returns to education” widens the income gap, while the “effect of labor structure” narrows the income gap; (2) The returns to education of urban residents under the college enrollment expansion policy is significantly higher than that of rural residents, resulting in the widening income gap among residents; (3) There is gender discrimination in the labor market. Women’s education opportunities have increased after the college enrollment expansion policy, however, the returns to education of female residents is still lower than that of male residents. Based on the empirical test results, relevant policies and suggestions are proposed from the perspective of educational development.
Prognostic Factors Impacting Post-Transplant Outcomes in Adult T-cell Acute Lymphoblastic Leukemia: A Registry-Based Study by the EBMT Acute Leukemia Working Party
Authors: Cheikh Jean El , Ngoya Maud , Galimard Jacques-Emmanuel , Remenyi P , Kulagin Alexander , Aljurf Mahmoud D , Bahar Babak , Wu Depei , Arat Mutlu , Salmenniemi Urpu , CASTILLA-LLORENTE Cristina , Socie Gerard , Helbig Grzegorz , schroeder thomas , Sakellari Ioanna , Rambaldi Alessandro , Carpenter Benjamin , labussiere helene , Stelljes Matthias , Brissot Eolia , giebel s , Peric Zinaida , Nagler Arnon , Ciceri Fabio , Bazarbachi Ali , Mohty Mohamad , Busca Alessandro
Published: January 2024

Background
T-cell acute lymphoblastic leukemia (T-ALL) predominantly affects individuals in late childhood and young adulthood. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative modality particularly in the setting of poor risk genetics and/or persistent minimal residual disease. Limited studies have directly explored the impact of patient- and transplant-related factors on post-transplant outcomes in T-ALL.
Methods
Using a large dataset from the European Society for Blood and Marrow Transplantation registry, we identified 1907 adult T-ALL patients (70% male) who underwent their first allo-HSCT in first complete remission (CR1) from matched sibling donors (MSD; 45%), unrelated donors (UD; 43%) or haploidentical donors (12%) between 2010 and 2021.
Results
The median age at transplant was 33.4 years (18.1–75). The median follow up was 2.9 years. Most patients underwent total body irradiation (TBI)-based myeloablative conditioning (69%). The 2-year overall survival (OS) was 69.4%, and leukemia -free survival (LFS) was 62.1%. In multivariate analysis, advanced age at transplant negatively affected LFS (for each 10-year increment, HR = 1.11, p = 0.004), GVHD-free, relapse-free survival (GRFS) (HR = 1.06, p = 0.04), OS (HR = 1.12, p = 0.002), and non-relapse mortality (NRM) (HR = 1.23, p < 0.001). A later year of HSCT was associated with improved GFRS (For each 3-year increment, HR = 0.89, p < 0.001), OS (HR = 0.9, p = 0.02), and decreased NRM (HR = 0.82, p = 0.008). TBI improved LFS (HR = 0.79, p = 0.02), GRFS (HR = 0.83, p = 0.04), and relapse incidence (RI) (HR = 0.65, p < 0.001). Female-to-male transplant negatively affected GRFS (HR = 1.21, p = 0.02) and OS (HR = 1.23, p = 0.048). In vivo T-cell depletion significantly improved GFRS (HR = 0.74, p < 0.001).
Conclusion
This large study identified prognostic factors, such as age at transplant conditioning regimen, in influencing post-transplant in adult T-ALL patients undergoing allo-HSCT. Importantly, a significant improvement over time was noted. These findings hold great promise for new adapted treatment strategies and can serve as a benchmark for future studies in that setting.
Mental Health Status and Suicidality Among Bangladeshi Health Care Workers: A Year After the COVID-19 Pandemic
Authors: Alam Md. Dhedharul , Paul Sujan Kumer , Momi Mahmuda
Published: January 2024

Background
The coronavirus 2019 (COVID-19) cases and death tolls in Bangladesh are still rising a year after the pandemic began. However, no published data is available on mental health status and suicidality among Bangladeshi healthcare workers (HCWs) after a year of the pandemic. This study aimed to investigate the mental health status and suicidality among Bangladeshi HCWs after a year of the COVID-19 pandemic.
Methods
A cross-sectional nationwide multicentre survey was conducted in Bangladesh from March 8 to July 2, 2021. This study used the Bangla versions of the General Health Questionnaire (GHQ-12) and three COVID-19-related suicidality questions to assess mental health status and suicidality.
Results
The questionnaire was completed by a total of 2,047 HCWs from Bangladesh. The study findings indicate that the prevalence rates of mental health disorders, suicidal ideation, suicide plans, and suicide attempts were 38.6%, 3.9%, 2.4%, and 1.1%, respectively. The multivariate analysis revealed that participants who lived in urban areas with lower socioeconomic status and were single were significantly more likely to experience mental health problems and suicidal ideation. Respondents who lived with family had a significantly lower chance of experiencing mental health problems and suicidal ideation. Moreover, respondents who worked as frontline workers were significantly more likely to suffer from mental health problems, suicidal ideation, suicide plans, and suicide attempts. Moreover, it was observed that those with fewer than five years of professional experience had a considerably elevated likelihood of encountering mental health issues, while concurrently displaying a diminished probability of experiencing thoughts of suicide. In addition, respondents who exercised daily had a considerably lower risk of mental health problems and suicidal ideation.
Conclusions
The enduring impact of the COVID-19 pandemic on the mental well-being of HCWs in Bangladesh continues to be substantial, with a notable prevalence of mental health issues and suicidal tendencies. Based on identified factors, this study recommends formulating effective strategies, timely psychological support, and interventions to mitigate mental health problems and suicidality in HCWs.
Solutions to improve the quality of higher education services in crises using soft systems methodology
Authors: ramezani sajad , moshtani mohamadreza jokar , talebi davood , Dorri Behrouz
Published: January 2024

The education sector encountered serious problems and the quality improvement of higher education services stopped after the Covid-19 pandemic. After the peak period of this virus, it is required to predict the crisis and consider appropriate solutions to improve the quality of higher education services. Thus, this study aimed to provide some solutions to improve the quality of higher education services in crisis situations. The combination of soft systems methodology with hesitant fuzzy best-worst method (HFBWM) was used to encounter the research problem. Based on soft systems methodology, three general areas were presented to improve the quality of higher education services. Such areas included solutions related to support services, solutions related to social development and team spirit, and improvement solutions related to management and planning. Thus, several solutions were provided in each area for Shahid Beheshti University. Finally, the solutions were prioritised based on the HFBWM. The establishment of updated educational systems, implementation of a strategic operational plan to improve services, and scientific consensus to improve education were considered as the prioritised solutions to improve the quality of higher education services in crises at Shahid Beheshti University.
Numerical Analysis for a piezoelectric contact problem with long-memory and wear
Authors: Oultou Abderrahmane , Baiz Othmane , Benaissa Hicham
Published: January 2024

In this paper, we consider a new mathematical model that describes a frictional quasi-static contact between a piezoelectric body with a long memory effect and a foundation. The contact is described with the normal compliance condition with unilateral constraint and a version of Archard’s wear law. We introduce the model and prove its weak formulation, which is composed of a history-dependent variational equality and an integral equation. Using abstract history-dependent variational inequality and fixed point theorem, we show the existence and uniqueness solution of the model. In addition, we introduce a fully discrete scheme for the numerical solution of the problem, based on the finite element method to approximate the spatial derivative, and on the Euler scheme to discretize the time derivative. Finally, we derive the optimal-order error estimate under appropriate regularity hypotheses.
MSC Classification: 74D10 , 74F15 , 74G30 , 47J20 , 49J40 , 35K86 , 74M10 , 74S05
The Therapeutic Role of Hyperoside in Medial Meniscus Destabilization-Induced Osteoarthritis: A Study on Subchondral Bone Remodeling
Authors: Yang Hua , Chen BinWei , Tang YE , Liao QiYue , Zhang Zhen , Liu Wei , Liu Sheng-Yao
Published: January 2024

Background The process of subchondral bone remodelling plays an imperative role in the progressive development of OA. Hyperoside (Hyp) is a flavonoid, which has a wide range of pharmacological effects. This study aims to explore the effect of Hyp on the subchondral bone to elucidate the therapeutic role of Hyp in medial meniscus destabilization (DMM) induced OA.Methods Firstly, we conducted histological research(HE staining, Safranin-O/Fast Green and Toluidine blue staining, TRAP staining, IHC) and microCT to test the ability of Hyp on cartilage degeneration and abnormal subchondral microstructural changes in the DMM-induced osteoarthritic mouse model. Secondly, In the in vitro experiments, RAW264.7 cells were induced to osteoblasts in the presence of different concentrations of Hyp and osteoclasts were labelled by TRAP staining. MC3TC-E1 cells were used to perform osteoinduction experiments in Osteogenic Induction Media (OIM). Osteogenic activity was observed through Alizarin red S staining, and mineralisation activity was observed through ALP staining. Last, Finally, the effect of Hyp on NF-κB pathways was studied using Western blot and immunofluorescence.Results Hyp decreased cartilage degeneration and improved BV/TV and Tb.Th structural parameters. It also reduced the number of TRAP-positive osteoclasts, nestin cells, and osterix cells in the subchondral bone. Additionally, Hyp Inhibits osteoclast formation and enhanced alkaline phosphatase activity and mineralization. Furthermore, the NF-κB signalling pathway related to osteoclasts was inhibited.Conclusion These results indicate that Hyp has potential therapeutic value for OA by modulating osteoclastogenesis and osteoblastogenesis in the subchondral bone.
Elective elderly patients undergoing thoracoabdominal surgery in the post- anesthesia care unit are at risk for inadequate emergence, (hypoactive emergence and emergence with delirium). A Cross-Sectional study
Authors: Bayable Samuel Debas , Debas Simachew Amogne , Alle Yewlsew Fentie , Amberbir Wubet Dessie , Fetene Melaku Bantie
Published: January 2024

Background:- This study aimed to ascertain the prevalence and contributing variables of unsatisfactory emergence after general anesthetic service for elderly patients undergoing thoracoabdominal operations.
Method: - In 2022, a cross-sectional study was carried out between December and June. All consenting patients participate with written informed consent after receiving ethical approval. Data has been collected through personally conducting interviews and chart reviews during the pre- and post-operative periods. The descriptive statistics were determined using cross-tabulation or frequency and percentage. Bi-variable and multivariable logistic regression models were fitted to identify predictive variables that were linked to the outcome variable. For multivariable regression, P-values of 0.05 were used to assess statistical significance.
RESULTS; - According to the current study, 90.5% (87.4-93.3) of surgical patients under general anesthesia experienced a normal emergence; in contrast, 5.70 %( 3.6-8.2) and 3.90 %( 2.1-5.9) of instances experienced an emergence with delirium and hypoactivity, respectively. A greater risk for emerging delirium was independently linked to anxiety, smoking, substance misuse, anemia, surgical history within three months, hypertension, metoclopramide prophylaxis, thiopentone, and pain ≥4 upon PACU admission,whereas male sex and patients who had ketofol induction were linked to a decreased chance of inadequate emergence. In elderly patients undergoing elective thoracoabdominal surgery, hypothermia in PACU, ASA III, exercise tolerance test (MET<4), and halothane, were found to be independently linked to hypoactive emergence, whereas pethidine, fluid intake ≥2000 ml, blood loss ≥500 ml, surgical duration >2 hrs, and PONV requiring antiemetic were significant risk factors for inadequate emergence.
CONCLUSION: - Despite the fact that risk factors are preventable, inadequate emergence is a common complication in elderly thoraco-abdominal surgery that presents challenges for anesthetists and PACU staff. Among elderly patients having thoraco-abdominal surgery, hypoactive emergence was less frequent than emergence delirium.