bluuebunny/crossref_metadata_2025 huggingface dataset:
Aplicaciones del proyecto GDELT en la conservación del patrimonio: el caso del IIMA (L. Kahn)
Authors:   Universidad de Granada, Vergara Muñoz Jaime , Martínez-Monedero Miguel ,   Universidad de Granada
Published: July 2022

La difusión a través de las redes sociales populariza el hecho arquitectónico. Su visibilidad contribuye a despertar una sensibilidad internacional, que en muchos casos finaliza con decisiones políticas y sociales en beneficio de la conservación de la arquitectura. El presente artículo aborda, como caso de estudio, la reciente propuesta de demolición del Indian Institute of Management de Ahmedabad (IIMA) de Louis Kahn en India. A través de este ejemplo se estudia de qué manera los mensajes que circulan en los medios de comunicación digitales pueden ser dirigidos para conseguir algún aspecto relacionado con su conservación. La metodología de la investigación ha sido fundamentalmente experimental, en la que se han considerado distintas variables: la realidad arquitectónica del Indian Institute of Management de Ahmedabad (IIMA), las noticias publicadas en distintos medios de comunicación digitales, y el tiempo que han permanecido las noticias en activo. Se emplea el Proyecto GDELT como herramienta para analizar las narrativas comunicativas presentes en la red de internet.
Reciprocal style and information transfer between historical Istanbul Pervititch Maps and satellite views using machine learning
Authors: Alaçam Sema , Karadag Ilker , Zeynel Güzelci Orkan
Published: July 2022

Historical maps contain significant data on the cultural, social, and urban character of cities. However, most historical maps utilize specific notation methods that differ from those commonly used today and converting these maps to more recent formats can be highly labor-intensive. This study is intended to demonstrate how a machine learning (ML) technique can be used to transform old maps of Istanbul into spatial data that simulates modern satellite views (SVs) through a reciprocal map conversion framework. With this aim, the Istanbul Pervititch Maps (IPMs) made by Jacques Pervititch in 1922-1945 and current SVs were used to test and evaluate the proposed framework. The study consists of a style and information transfer in two stages: (i) from IPMs to SVs, and (ii) from SVs to IPMs using CycleGAN (a type of generative adversarial network). The initial results indicate that the proposed framework can transfer attributes such as green areas, construction techniques/materials, and labels/tags.
A. Bonet y J. L. Sert. El espíritu “renacentista” en el impulso de una modernidad trasatlántica en clave mediterránea
Authors: Tabera Roldán Andrés , Fernández Aitor Acilu
Published: July 2022

A finales de 1920, los arquitectos Sert y Torres Clavé encontraron en el espíritu del renacimiento, en el estudio de las revistas modernas europeas y en el contacto con Le Corbusier y los CIAM, la inspiración para hacer del GATCPAC un motor de nuevas propuestas en arquitectura, urbanismo y mobiliario en claves mediterráneas. Un joven Antonio Bonet, todavía estudiante, colaboró en este cometido para años después, entre 1938 y 1950, hacer renacer en Buenos Aires el espíritu vanguardista de sus años formativos. A través de la revisión comparativa de proyectos de diversa naturaleza —editorial, urbanística y en torno a la figura de Gaudí—, desarrollados respectivamente por Sert y Bonet en sus particulares experiencias americanas entre 1938 y 1960, este artículo pretende descubrir paralelismos que contribuyeron al desarrollo de una modernidad mediterránea y trasatlántica, en la que la actitud de “renacer” fue reiterada.
Del impacto de una ciencia abierta en arquitectura y urbanismo
Authors: Jiménez-Pacheco Pedro
Published: July 2022

ciencia abierta, citación de impacto
Evaluation of the effect values of risk factors by clustering method in patients who died due to COVID-19 disease
Authors: METİN Salih , ERAYBAR Suna , AYGÜN Hüseyin , ERCAN İlker , DEMİR Canan
Published: July 2022

Objectives: The aim of this study is to determine the factors that may be associated with mortality in patients who died due to COVID-19 and to determine the effect sizes of the factors that make a statistically significant difference.
Methods: The patients who died due to COVID-19 between 01.03.2020 and 01.03.2021 in Bursa province were evaluated retrospectively. In addition to demographic information such as age, gender, nationality, existing chronic diseases of the patients, COVID- PCR test results, length of hospital stay, intensive care unit follow up times, intubation application times were recorded. The effect size of the variables on mortality were evaluated.
Results: Total of 3,510 deaths due to COVID-19 were evaluated. Of these, 2,107 (60%) were male and 1,403 (40%) were female. Three thousand three hundred and seventy-four (96.12%) patients are 50 years or older. In both sexes, the highest number of deaths were in the age range of 70-79. The most common comorbidities were hypertension (HT) (n = 1,182; 34.16%) and diabetes mellitus (DM) (n =776; 22.43%). HT and DM had a strong effect value between the groups (p < 0.001 and p < 0.001, phi effect values: 0.661 and 0.681, respectively). Although there was a statistically significant difference for the age variable, it had an insignificant effect value (p = 0.008, 𝛿 = 0.074).
Conclusions: Risk factors frequently reported for COVID-19 deaths but there are no studies showing the true effect values. In this study, HT and DM had a strong effect separately, gender and coronary artery disease (CAD) variables were moderate, chronic obstructive pulmonary disease (COPD), lung cancer and other chronic disease variables had weak effect values, age and non-lung cancers had insignificant effect.
The assessment of the biological age of children`s characters created in the convention of Japanese animation in forensic practice
Authors: Bisiecka Agata , Brysławski Krzysztof
Published: July 2022

Introduction: According to criminal codes of most Western countries, possessing, producing and disseminating of fictional paedopornography is a crime. In light of these laws, the shotacon/lolicon (popular and widely available Japanese animations or comic books showing minors in a sexual context) seems to deserve special mention. There have been several convictions for violations of these laws, however, the methodology of a depicted person’s age estimation is still unestablished.
The aim of this study was to assess the suitability of anthropometrical prediction of age to the analysis of characters animated in the Japanese style.
Material and methods: The metric (distance between facial landmarks) and non-metric (type of chin shape) features of 173 animated characters’ faces were obtained. Material was collected from 90 most popular Japanese anime series. Measurements were conducted in ImageJ software. The correlations of age and standardized measurements: en-ex, en-en, eye height, pu-prn, pu-sto, pu-gn were examined. The chin shape was described by three independent ‘judges’.
Results and conclusions: Correlations for pu-prn, pu-sto, pu-gn and eye height in females and in all males were statistically significant. Age prediction was made using linear regression equations. Good prediction (± 1 year) was obtained for 44% males and 17% females. Prediction within the acceptable range (± 2 years) was achieved for 23% of males and 18% of females. In total, the prediction with an error of no more than ± 2 years was obtained for 67% of males and 35% from females, which is comparable to the results obtained in the study of real children. Moreover, triangular or rounded chin shape was significantly more frequent in boys aged 10–12 years, and square in older boys 16–18 years. Current research provides a basis for developing a methodology for assessing the age of animated characters. There is a need for further research in this area.
Strategi Kepala Sekolah dalam Mengembangkan Mutu Pendidikan
Authors: Ghofur Muhammad Abdul , Sa'ada Layliya Zahrotus
Published: July 2022

This study aims to illustrate the principal's strategy in developing the quality of pre-eminent Islamic elementary school education in Integrated Islamic Elementary School Iqro Kangploso Malang. This type of research uses qualitative methods, studies. Data collected through observation, interviews and documentation. The results of this study indicate that the principal's strategy in developing the quality of Education includes 1) formulating a plan by formulating a vision, short-term mission and medium-term goals (4 years); 2) implementing strategies by increasing discipline, increasing UN results, conducting extracurricular activities, establishing cooperation with the community.
Supervisi Kepala Madrasah dalam Mengembangkan Kompetensi Profesional Guru
Authors: Subaidi Subaidi , Jupri Jupri , Munasir Munasir
Published: July 2022

Tujuan dari penelitian ini adalah untuk menganalisis tentang pelaksanaan supervisi akademik dalam meningkatkan profesional guru di MA Darul ‘Ulum di Taman Sari Pati, yang meliputi progam, pelaksanaan, evaluasi, factor pendukung dan penghambat yang dihadapi kepala Madrasah Aliyah Daarul ‘Ulum Taman Sari Pati. Melalui kegiatan supervisi, madrasah dapat membantu guru yang mengalami kesulitan dalam kegiatan pembelajaran dan untuk meningkatkan profesionalismenya. Penelitian ini mengunakan penelitian kualitatif. Teknik pengumpulan data dengan menggunakan data observasi, wawancara dan dokumentasi, subyek penelitian kepala Madrasah, wakil kepala Madrasah dan guru. Hasil peneitian ini antara lain; supervisi kepala madrasah dalam mengembangkan kompetensi profesional guru berjalan sebagaimana yang direncanakan. Peningkatan kompetensi profesional guru hasilnya meliputi; penguasan materi, menguasai kompetensi dasar, mengembangkan materi, mengembangkan profesionalitas secara berkelanjutan dengan melakukan tindakan reflektif, memanfaatkan teknologi informasi dan komunikasi.
Academic Optimism Levels of Schools Examining the Relationship between Perceived Principal Management Style According to Teachers' Views
Authors: İVGİN Ali , DEMİRTAŞ Hasan
Published: July 2022

In this study, it is aimed to examine the relationship between the academic optimism levels of schools and the management styles of school principals. In addition to causal comparison, relational screening methods were also used in the study. The universe of the research consists of teachers working in public schools in Adıyaman city center in the 2020/2021 academic year. For this purpose, online data were collected from 353 teachers working in 51 public schools in Adıyaman city center. The data were analyzed with the SPSS program; Parametric and non-parametric tests were applied according to normality assumptions. As a result of the research, it was seen that the opinions of the teachers about the academic optimism of their schools and the perceived principal management style differed significantly according to the variables of gender, branch, school level and number of teachers. According to the teachers' views, there is a positive and "moderate" relationship between their school's views on academic optimism and their collaborative management style; A negative “low” relationship was found between academic optimism and disinterested management style, authoritarian management style and oppositional management style.
CLUSTER ANALYSIS OF INTEGRATED “DRUG SUPPLY” CONCEPT
Authors: Barkaev G. S. , Kabakova T. I. , Goryachev A. B.
Published: July 2022

The aim of the article is the structure and content specification of the subject area professional term “drug supply” in order to deepen and concretize the conceptual apparatus in the field of the pharmaceutical activity.

Materials and methods. The review presents the analysis of 389 titles of scientific pharmaceutical publications for the periods of 1995–1998 and 2010–2019. The selection of publications was carried out by the random sampling based on the phrases: «drug provision», «medical care», «provision of medicines», «pharmaceutical care», «medicinal services», «drug supply» and their English-language counterparts in Russian and foreign electronic information sources. A methodological base of the study was a cluster analysis of the subject area concept of “drug supply” according to the methodology proposed by E.A. Korzhavykh and I.V. Voronovich. In this study, a cluster was interpreted as a set of publications in which a certain pair of terms was simultaneously cited with a preset frequency of co-citation.

Results. When analyzing the publications, two clusters of the “drug supply” concept were formed for the time periods indicated above. The comparison of the clusters showed an increase in the activity of the scientific research to expand the structure and content of the subject area of the “drug supply” concept. For the modern cluster, 124 co – cited pairs of lexical units were selected. They were grouped into 9 hierarchy levels according to the strength of relationship between an interval of 10 units and mentioning frequencies of the “drug supply” term. At the final stage, a graphical model of the “drug supply” concept cluster was formed. It was established that the lexical units included from the first to the fifth level, are the cluster nucleus of the “drug supply” concept as the most stable part of the lexical array, which it is advisable to rely on when developing a definition for the concept under study.

Conclusion. Thus, the subject field of the “drug supply” concept is characterized by the scientific research, reflecting the socio-economic significance of the objects under study in the field of pharmaceutical activities, and its content is characterized by a high level of pharmaceutical knowledge which describes the most stable elements that make it possible to formulate an adequate definition of the “drug supply” definition.
OPTIMIZATION TECHNOLOGY OF FAT-SOLUBLE VITAMINS PRODUCTION BASED ON ALKALINE HYDROLYSIS
Authors: Sysuev E. B. , Stepanova E. F. , Noskova V. D.
Published: July 2022

In the group of fat-soluble vitamins, vitamin D is one of the most relevant objects, that is why the problem of its technology optimization is under consideration. In general, there is a number of ways to obtain this substance, although it is not produced in Russia yet.

The aim of the study was to select optimal process conditions to increase the efficiency of protein transformation with the isolation of a fat fraction containing fat-soluble vitamin D.

Materials and methods. Various types of fish and the vitamins contained in them are described as the main research models. Variants of technological solutions have been considered: the possibility of using extraction to obtain the vitamin D substance has been tested. Classical maceration and intensifying maceration have been used; the circulating extraction method and the alkaline hydrolysis method have been applied. The yield of the target product has been determined by HPLC.

Results. Methods for obtaining the substance of fat-soluble vitamin D from fish raw materials have been considered in detail. The optimal technological characteristics of the vitamin release by alkaline hydrolysis with a 12.5% decrease in the concentration of the hydrolyzing alkaline component – potassium hydroxide – has been established; that concentration ensured the maximum yield of the fat fraction containing vitamin D.

Conclusion. The use of the resulting substance makes it possible to develop domestic standard samples applicable both in the pharmaceutical field and in the field of technical regulation.
POLYPHARMACY IN MANAGMENT OF IN-PATIENTS WITH NOVEL CORONAVIRUS DISEASE (COVID-19)
Authors: Petrov V. I. , Ryazanova A. Yu. , Privaltseva N. S. , Nekrasov D. A.
Published: July 2022

The aim. To identify polypharmacy cases and develop the ways to optimize pharmacotherapy of patients with COVID-19 hospitalized in infectious disease facilities.

Materials and methods. ATC/DDD analysis with calculation of DDDs/100 bed days and a sample analysis of 500 patients’ prescriptions were performed for presenting drug utilization statistics in the infectious disease facilities of Volgograd region, which had been reassigned to treat patients with COVID-19 in 2020 and 2021.

Results. Five or more drugs were administered simultaneously in 96.8% of patients. Antibacterial drugs were in 74.3% of the analyzed prescriptions in 2020 and in 73.5% in 2021. The total consumption of antibiotics was 102.9 DDDs/100 bed-days in 2020 and 95.7 DDDs/100 bed-days in 2021. The cases of multiple administrations of biological disease modifying antirheumatic drugs and the use of cyclophosphamide have been identified. In 73.6% of prescriptions in 2020 and 85.4% of 2021, omeprazole at the dose of 40 mg per day was used (77.3 and 84.6 DDDs/100 bed-days, respectively). In 2021, there were cases of concomitant intravenous prescribing of acetylcysteine under the trade name of Fluimucil® with tableted forms of ambroxol and acetylcysteine under the name of ACC®. The cumulative consumption of hepatotoxic drugs was 269.2 DDDs/100 bed-days in 2020 and 401.5 DDDs/100 bed-days in 2021.

Conclusion. Lack of drugs with proven effectiveness for treatment of COVID-19, worked-out treatment algorithms, a high mortality of patients in the hospitals led to polypragmasy, excessive prescribing of drugs in the hospitals. The prescription of antibacterial drugs, omeprazole, mucolytics, hepatotoxic drugs, immunosuppressors in infectious hospitals should be monitored by clinical pharmacologist.
Library Organization Issues in The Digital Era (Case Study: Copyright and Plagiarism in The Library Environment)
Authors: Saputri Nurjannah
Published: July 2022

This article describes the issues that occur in library organizations in the digital era. One of them is about plagiarism and copyright. Both are interrelated as a result of technological developments in this digital era. The purpose of this article is to provide an overview to the reader about one of the issues that occur in library organizations and what steps should be taken to avoid this issue. The research method used is literature study, the data obtained from books and journals related to the problems discussed in this article. The focus of this article is on plagiarism and copyright in the library environment. What is the role of libraries in dealing with plagiarism and copyright issues. From this study, the results obtained are that it is known that along with the times, some human activities can be carried out online using information technology networks. The positive impact of this is that information technology is used to disseminate and can easily obtain information instantly, and make it easier to do tasks. However, the negative side is that there is plagiarism against the work of someone who violates the copyright of the work. Based on the results of a literature study of an article, it is known that not a few people commit plagiarism. So, from this research, it can be concluded that one of the most basic preventions to eliminate the negative side is honesty with oneself, and in writing scientific papers, clear sources must be included in order to avoid plagiarism of the paper. In addition, technological advances have created software that can minimize writers from plagiarizing written works.
Design of Library Information Systems for Collections Procurement at Hayam Wuruk Perbanas Library
Authors: Ramadhani Aditya , Prayitno Dio Eka
Published: July 2022

Information disclosure is an opportunity and a challenge for libraries in managing information. Management of this information must be done quickly and precisely so that people can consume information according to their needs. Libraries take an important role in such conditions because the library as an information management organization has a strategic role so that the information circulating can be in accordance with the needs of the community. Up-to-date information is one way for the public to get appropriate information and this must be done by the library so that the existence and value of its benefits can be felt by the community. The community can take a role in supporting the updating of the information. One way to keep the information up to date is to adjust the collection of library materials by conducting it. The approach that is owned by the library is to monitor the process of procuring a collection of library materials carried out by the library. Librarians can build an information system design that can accommodate these activities. The research method used in this article is a research with a qualitative descriptive approach in the form of a case study. This article aims to offer an information system for the procurement of library material collections carried out by the Hayam Wuruk Perbanas University Surabaya Library. The result is a proposed information system for the procurement of a new collection of library materials with an open nature so that all stages or the process of procuring a collection of library materials can be monitored together and users can find out the up-to-date collection of library materials owned by the library.
Yeni tanı konulan hipertansif hastalarda antihipertansif ilaç başlanmasının MPV düzeyine etkisi
Authors: AYBAL KUTLUGÜN Aysun , KAPLAN EFE Fatma , BİTEN-GÜVEN Gülsüm
Published: July 2022

Trombosit aktivasyonu hipertansiyon patogenezinde rol oynayan bir faktördür. Ayrıca, trombotik olayların gelişimine ve hipertansiyona bağlı hedef organ hasarına katkıda bulunur. Mean platelet volume, platelet aktivasyonunu gösteren kolay ölçülebilir bir parametredir. Bu çalışmanın amacı, yeni tanı almış hipertansif hastalarda antihipertansif ilaç tedavisine başlandıktan sonra MPV düzeylerinde herhangi bir değişiklik olup olmadığını değerlendirmektir. Antihipertansif ilaç tedavisine başlanan 79 hasta retrospektif olarak değerlendirildi. Hastaların% 24.1'inde mikroalbüminüri vardı. Antihipertansif ilacın başlamasından önceki ve sonraki MPV değerleri (5.8=3.6 ay) istatistiksel olarak karşılaştırıldı. Antihipertansif ilaç tedavisine başlandıktan sonra ortalama MPV değerinde istatistiksel olarak anlamlı azalma saptandı (8.92=1.76 fl'ye karşılık 8.38=1.60 fL, p<0.001). Ortalama MPV değeri mikroalbüminürik grupta normoalbüminürik gruba göre daha yüksekti (9.24=1.10 fLvs. 8.49 = 1.75 fL, p = 0.028). Yeni tanı konulan hipertansif hastalarda antihipertansif ilaç başlanmasını takip eden ilk yıl içinde ortalama MPV düzeyinde anlamlı bir azalma tespit edildi.
Mscligan- A Structure-Informed Generative Adversarial Model for Multi-Site Statistical Downscaling of Extreme Precipitation -Using Multi-Model Ensemble
Authors: Chaudhuri Chiranjib , Robertson Colin
Published: July 2022

Although the statistical methods of downscaling climate data have progressed significantly, the development of high-resolution precipitation products continues to be a challenge. This is especially true when interest centres on downscaling value over several study sites. In this paper , we report a new downscaling method termed the multi-site Climate Generative Adversarial Network (MSCliGAN), which can simulate annual maximum precipitation to the regional scale during the 1950-2010 period in different cities in Canada by using different AOGCM's from the Coupled Model Inter-Comparison Project 6 (CMIP6) as input. Auxiliary information provided to the downscaling model included topography and land-cover. The downscaling framework uses a convolution encoder-decoder U-net network to create a generative network and a convolution encoder network to create a critic network. An adversarial training strategy is used to train the model. The critic/discriminator used Wasserstein distance as a loss measure and on the other hand the generator is optimized using a summation of content loss on Nash-Shutcliff Model Efficiency (NS), structural loss on structural similarity index (SSIM), and adversarial loss Wasserstein distance. Downscaling results show that downscaling AOGCMs by incorporating topography and land-use/land-cover can produce spatially coherent fields close to observation over multiple-sites. We believe the model has sufficient downscaling potential in data sparse regions where climate change information is often urgently needed.
Trastuzumab Biosimilar ABP 980 Plus Pertuzumab and Docetaxel in the Therapy of Metastatic Breast Cancer: Real World Experiences from the National Research Institute of Oncology in Warsaw
Authors: Miacz Karolina , Jagiełło-Gruszfeld Agnieszka , Kunkiel Michal , Lemanska Izabela , Gorniak Anna , Niwinska Anna , Nowecki Zbigniew I.
Published: July 2022

Background: Human epidermal growth factor receptor 2 (HER-2) overexpression can be found in 15-20% of breast cancers, and it strongly correlates with aggressive clinical behavior and adverse prognosis. The first-line treatment for HER-2 positive metastatic breast cancers is the combination of trastuzumab, pertuzumab, and taxane (PTH). ABP 980 is a biosimilar of the innovator trastuzumab and is characterized by highly comparable effectiveness. Methods: The group of 61 patients with HER-2 positive MBC received biosimilar ABP 980 plus pertuzumab and docetaxel from November, 18, 2018 to December, 24, 2019. The response to therapy, overall survival (OS), progression-free survival (PFS), metastases, and adverse effects among patients were determined and analyzed. Results: Initially, 42 women responded partially to the treatment and their median PFS was 27 months. Median PFS for the whole group was 18 months. Cardiotoxicity of treatment was noticed in all patients in the form of the reduction in left ventricular ejection fraction but only in 2 cases, it was the reason for withdrawing from therapy. Conclusion: Biosimilar ABP 980 is registered in the same indications as the innovator trastuzumab and their effectiveness, as well as side effects, are comparable. The costs of biosimilar make the therapy more accessible and thus more patients with MBC around the world can receive relevant treatment.
Probiotic as A Potential Gut Microbiome Modifier for Stroke Treatment: A Systematic Scoping Review of in vitro and in vivo Studies
Authors: Savigamin Chatuthanai , Samuthpongtorn Chatpol , Mahakit Nuttida , Nopsopon Tanawin , Heath Julia , Pongpirul Krit
Published: July 2022

Background: Pharmacologic and non-pharmacologic treatments for stroke are essential but could be costly or harmful whereas probiotic has been a promising alternative. This scoping review aimed to synthesize the in vitro and in vivo evidence of probiotics on stroke-related neurological, biochemical, and histochemical outcomes. Method: We searched in PubMed, Embase, and Cochrane Central Register of Clinical up to May 7, 2021, and screened by two independent reviewers. We included the use of probiotics, prebiotics, and symbiotics both in vitro and in vivo for the prevention or treatment of the stroke-related model. Result: Of 6,293 articles, 4,990 passed the initial screen, of which 36 theme-related full-texts were assessed and 13 were included in this review. Probiotics could ameliorate the neurological deficit and show their property as an anti-inflammation and anti-oxidative stress. Histopathologically decreased loss of cerebral volume and inhibition of neuronal apoptosis were found. Conclusion: There are potential cognitive benefits of probiotic supplementation, especially among animal models, on decreasing cerebral volume, increasing neurological score, and decreasing the inflammatory response. However, further investigation is needed to validate these conclusions in various populations.
Clinical and Evolutionary Features of SARS Cov-2 Infection (COVID-19) in Children, A Romanian Perspective
Authors: Jugulete George , Pacurar Daniela , Pavelescu Mirela Luminita , Safta Mihaela , Gheorghe Elena , Borcos Bianca , Pavelescu Carmen , Oros Mihaela , Merisescu Madalina
Published: July 2022

Background: Given the potential for additional development to clarify a better knowledge of the overall impact of COVID-19 on the pediatric population, the clinical symptoms of SARS-CoV-2 infection in children and adolescents are still being explored. Morbidity in children is characterized by a variable clinical course. Our study's goal was to compare clinical aspects of 230 pediatric patients who tested positive for SARS-CoV-2 and were hospitalized between April 2020 and March 2022. Methods: In a retrospective analysis, we compared two groups hospitalized in the infectious diseases clinical ward IX at the National Institute for Infectious Diseases "Prof. Dr. Matei Bals," Bucharest, Romania. The first group of 88 patients was admitted between (April–December 2020) and their clinical manifestations were compared with the second group of 142 children followed between July 2021 and March 2022. Results: Of 230 children, the median age was 4.5 (interquartile range 0.6-17) years, 53.9% were male. 88 (36.21%) patients (first group) were admitted during the second wave in Romania, mostly aged < 5 years old, and experienced digestive manifestations like fever (p=0.001), and diarrhoea (p=0.004). The second group experienced different clinical signs when compared with the first group, with higher temperature and increased respiratory symptoms analogous to those of acute respiratory viral infections. The proportion in the second group increased, and 64.5% had symptoms for a median interval of 5 days; age (0-4 -years old) and length of stay were both proportionally inversely (p<0.01) and with correlation with hospital admission (p = 0.04). We report two Paediatric Inflammatory Multisystem Syndrome (PIMS) in the second group, with favourable evolution under treatment. Comorbidities were risk factors for complications appear (p < 0.001) in both groups. All paediatric cases admitted to our clinic evolved favourably and no death was recorded. Conclusions: In the first group children experienced digestive symptoms, whereas the second group experienced mild and moderate respiratory symptoms. We confirmed risk factors for severe cases as manifestations across the age spectrum, 0-4 (digestive symptoms) and 5-12 years old (for respiratory symptoms), associated comorbidities, fever, and male gender. The potential effects of COVID-19 infection in children older than 5 years should encourage caregivers to vaccinate and improve the prognosis among pediatric patients at risk.
An Innovative Method for Approximating Arcsine Function
Authors: Othman Slim Ben , Bagul Yogesh J.
Published: July 2022

This paper presents a new method for approximating the classical arcsine function. The proposed approximating methodology is simpler in its approach than other classical approaches and undeniably innovative. It is based on matrix representation besides the basic interpolation to approximate the inverse trigonometric function. It provides an efficient model which allows for reliable and precise calculations. The results are as per our knowledge unseen results in the previous literature.
Weak Gravitational Lensing in Dark Matter and Plasma Mediums for Wormhole-like Static Aether Solution
Authors: Javed Wajiha , Riaz Sibgha , Pantig Reggie C. , Övgün Ali
Published: July 2022

In this paper, we study the deflection angle for wormhole-like static aether solution by using Gibbons and Werner technique in non-plasma, plasma and dark matter mediums. For this purpose, we use optical spacetime geometry to calculate the Gaussian optical curvature, then implement the Gauss-Bonnet theorem in weak field limits. Moreover, we compute the deflection angle by using a technique known as Keeton and Petters technique. Furthermore, we analyze the graphical behaviour of the bending angle ψ with respect to the impact parameter b, mass m as integration constant and parameter q in non-plasma and plasma mediums. We examine that deflection angle is exponentially increasing as direct with charge. Also, we observe that for small values of b, ψ increases and for large values of b the angle deceases. We also considered an analysis to the shadow cast of the wormhole relative to an observer at various locations. Comparing it the the Schwarzschild shadow, shadow cast is possible for wormhole as r<2m. At r>2m, the Schwarzschild is larger. As r → ∞, we have seen that the behavior of the shadow, as well as the weak deflection angle, approaches that of the Schwarzschild black hole. Overall, the effect of plasma tends to decrease the value of the observables due to the wormhole geometry.
Asbestos-Related Diseases and Policies: an Update
Authors: Jargin Sergei
Published: July 2022

Asbestos-related risks have been estimated on the basis of data from the past, when professional exposures were higher. Fibers are present in the environment due to erosion of surface deposits and human activities unrelated to asbestos industry. If searched for, asbestos fibers are frequently found at autopsies. Bias can be encountered in asbestos research e.g. attributing of mesothelioma and lung cancer to asbestos when fibers are present, although cause-effect relationships remain unproven. Some studies rely on work or residence histories of questionable reliability. Asbestos is banned in some countries while others are increasing production and exports. Asbestos is a low-cost material and an excellent reinforcing fiber. Different asbestos types have their technical advantages and preferred application areas. The traffic is safer with asbestos-containing brake linings. Asbestos cement constructions are sturdy and inexpensive. The fireproofing properties of asbestos are well known. It can be reasonably assumed that the non-use of asbestos-containing brakes, fireproofing and insulation lagging has increased the damage and numbers of victims of traffic accidents, fires and armed conflicts. Nowadays, when a probability of conflicts seems to be enhanced, the attitude to asbestos should be changed. Most importantly, asbestos-related science must be separated from economical and political interests. Reliable information can be obtained in lifelong bioassays.
Levels of some serum cytokines and chemokines in children with coronavirus infection
Authors:   Chita State Medical Academy, Chita, Russian Federation, Peregoedova V.N. , Bogomolova I.K. ,   Chita State Medical Academy, Chita, Russian Federation, Babkin A.A. ,   Chita State Medical Academy, Chita, Russian Federation, Tereshkov P.P. ,   Chita State Medical Academy, Chita, Russian Federation
Published: July 2022

Objective. To measure serum levels of some cytokines and chemokines in children depending on the severity of coronavirus infection. Patients and methods. We examined 33 children aged 4 to 17 years with coronavirus infection, including 25 patients with mild disease (Group 1; mean age 11 [6.5; 14] years) and 8 children with moderate disease (Group 2; mean age 11 [8; 13] years). The control group comprised 30 healthy children matched for age (mean age 10 [6; 12] years). The following cytokines and chemokines were measured in all study participants using the LEGENDplexTM Human Essential Immune Response Panel (BioLegend, USA): interleukins (IL)-1β, -2, -4, -6, -8, -10, -12p70, -17A, interferon-induced protein (IP-10), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ). Data analysis was performed using the IBM SPSS Statistics Version 25.0 (International Business Machines Corporation, license No Z125-3301-14, USA). Results. We found that children with coronavirus infection had elevated serum levels of IL-1β, IL-2, IL-4, IL-12p70, IL-17A, IP-10, and MCP-1 regardless of their disease severity compared to controls. Patients with moderate disease demonstrated higher serum levels of IL-12p70 and MCP-1 compared to those with mild disease. The ROC-analysis showed that IL-12p70 and MCP-1 can predict moderate course of coronavirus infection in children. Conclusion. Serum levels of IL-12p70 and MCP-1 can be used as an additional diagnostic marker to estimate the inflammation severity in children with coronavirus infection. Key words: children, coronavirus infection, disease severity, chemokine, cytokine, COVID-19, SARS-CoV-2
Prevalence of Cardio-vascular Disease Risk Factors among Adolescents of Urban Field Practicing Area of MIMS Medical College, Vizianagaram
Authors:   Assistant Professor, Department of Community Medicine, MIMS Medical College, Vizianagaram, Andhra Pradesh 535217, India., Samantaray Aurobindo , Nayak Bikash Chandra ,   Assistant Professor, Department of Community Medicine, MIMS Medical College, Vizianagaram, Andhra Pradesh 535217, India., Maitreyi N. ,   MBBS Student, MIMS Medical College, Vizianagaram, Andhra Pradesh 535217, India., Kar Padmaja Priyadardhini ,   Tutor, Department of Pharmacology. MIMS Medical College, Vizianagaram, Andhra Pradesh 535217, India.
Published: July 2022

Background: Cardiovascular diseases are the number one cause of death globally. Over three quarters of CVD deaths take place in low and middle income countries. The mortality varies from <10% in rural locations in less developed states to >35% in more developed urban locations. Most cardiovascular diseases can be prevented by addressing behavioural risk factors such as tobacco use, unhealthy diet and obesity, physical inactivity and harmful use of alcohol using population¬ wide strategies. Objectives: 1. To study the demographic profile of study population. 2. To determine the prevalence of cardio¬vascular disease risk factors among study population. 3. To suggest measures for prevention of cardio¬vascular diseases. Methods: This study is a community based cross-sectional study conducted from June 2017 to July 2017 involving adolescents of the age group 10 to 19 years from the Urban Field Practice area of MIMS Medical College. Data was collected in a predesigned and pretested schedule and analyzed using SPSS version17. Results: Out of 328 participants, 185 (56.4%) were male and rest 143 (43.6%) were female. Among them 3.6% were hypertensive, 6.7% were Obese, tobacco intake and history of alcohol intake in last 30 days was present in 11.9% and 4.3% of male participants respectively. Conclusion: Many CVD risk factors are prevalent in the adolescents of the study area which can be prevented by healthy lifestyles such as healthy diet, regular exercise and personal awareness.
Semyon L. Frank on the “secret of transcendence”: lecture version of the “Object of Knowledge”
Authors:   St. Tikhon’s Ortodox University, Rezvykh Tatyana N. , Tsygankov Alexander S. ,   Institute of Philosophy, Russian Academy of Sciences
Published: July 2022

Based on archival materials, personal correspondence and Swiss periodicals, a historical and philosophical reconstruction of the circumstances of Semyon L. Franck’s lecture visit in Switzerland in 1929 have been performed. The place and significance of the report “The Secret of Transcendence” (“Das Rätsel des Transzendenz”), which was given in Zurich at the invitation of the local Philosophical Society, in the philosopher’s creative heritage was established. It was concluded that the content of Semyon L. Frank’s lecture is reflected the epistemological problems that the philosopher set out systematically in his pre-emigrant work “The Object of Knowledge” (1915), and then presented it to the Ger­man-speaking professional community in an abridged form in two articles published un­der the general title “Cognition and Being” (“Erkenntnis und Sein”) in 1928 and 1929 in the German edition of the international yearbook on the philosophy of culture “Lo­gos”. The appendix introduces the German-language synopsis of Semyon L. Frank “The Secret of Transcendence”, stored in Box 16 of the Philosopher’s Foundation in the Bakhmetev Archives of Columbia University (New York, USA) – Bakhmeteff Archive of Russian and East European History and Culture, Rare Book & Manuscript Library, Co­lumbia University, New York. S.L. Frank Papers. Box 16. S.L. Frank – Manuscript Frag­ments Notes; archival materials are provided with Russian translation and comments.
A.S. Izgoev’s vision of intelligentsia
Authors:   National Research University “Higher School of Economics”, Chernovskaya Maria A.
Published: July 2022

A special footnote was added to the article “Educated Youth (Notes on its Life and Senti­ments)”, included in the famous collection of essays Vekhi (1909), in which author A. Iz­goev expressed his disagreement with a “common platform” of the collection, outlined by M. Gershenzon in the introduction. What was the reason for Izgoev’s rejection of the as­sertion that an individial’s inner life is the only foundation on which a society can be built? If Izgoev had criticized the ideas on intelligentsia proposed by some of Vekhi’s con­tributors back in 1903, why did he agree to become one of Vekhi’s contributors himself and, moreover, why did he defend Vekhi from accusations of conservatism after the publication of the volume? In our opinion, answers to these questions can be found in Izgoev’s theory of intelligentsia. The present paper is an attempt to reconstruct that theory. Izgoev believed that the conception of intelligentsia proposed by narodniks (in particular, N. Mikhaylovsky) and by neoidealists (N. Berdyaev and S. Bulgakov) was incorrect be­cause it did not take into account the material interests of this social group. Intelligentsia earns an income by teaching and doing research, and with a lack of freedom of speech and thought in the state cannot execute its functions because the latter require a spiritual freedom. Representatives of intelligentsia can unite to fight for freedom. This is benefi­cial for the intelligentsia itself and contributes to the progress of the whole nation. De­spite Izgoev’s disagreement with treating intelligentsia as a higher-class group that does not pursue its material interests, he, as other authors of Vekhi considered it to be the only group that was capable of transforming Russia into a democratic and law-governed state.
The participation of S.L. Frank in The Eighth International Congress of Philosophy in Prague
Authors:   The Pontifical University of John Paul II (Poland), Obolevitch Teresa
Published: July 2022

The article examines the role that Czechoslovakia played in S.L. Frank’s life and phi­losophical path, especially the famous “Russian Action” initiated by President T.G. Masaryk. The previously unknown publications of Franck published in Czechoslo­vakia are established, due to which the bibliography of the philosopher is enriched. We made an attempt to establish the reasons why Frank ultimately refused to move to Prague, despite numerous invitations from other Russian emigrants. A special place is devoted to Frank’s participation at the Eighth International Congress in Prague, which took place in 1934. On the basis of archival materials, we consider the circumstances of Frank’s in­vitation to the congress, the contents of his lecture “The Present Spiritual Situation and the Idea of Negative Theology” held on September 5, 1934, in the “Religion and Philoso­phy” section, and Frank’s speech in the discussion with the Dutch philosopher H.J. Pos. The general historical and philosophical context of S.L. Frank’s talk at the Congress is re­constructed, taking into account the sociopolitical situation of the 1930s. In addition, the reception of Frank’s report by Russian thinker on the basis of remarks on his lecture as well as his own texts, which represent a review of the Eighth International Congress, is considered.
Farewell to Jean-Luc Nancy
Authors:   Université de Strasbourg (France), Rogozinski Jacob
Published: July 2022

Many periodicals responded to the message that the “philosopher of corporeality”, the “thinker of being-together” passed away. Detailed reflections on Nancy’s place in the modern intellectual landscape were also published in Russia. In the first publica­tion of this text written in memory of his colleague, Jacob Rogozinsky traces the move­ment of his thought on issues with which the name Nancy is inextricably linked, de­scribes his approach and his own method in research on religion, body, community, democracy, which glorified him all over the world and which indicate the greatness of this philosophers for our time.
Realism vs Militarism: Elem Klimov’s Depiction of War
Authors:   National Research University Higher School of Economics, Gulyaev Roman V.
Published: July 2022

The article examines how film ‘Come and See’ by Elem Klimov corresponds to ethical problems of classical theory of war. Soviet reviewers tended to interpret it as an opposition between humanity and inhumanity of Soviet and Nazi sides respectively. We assume that Klimov’s film depicts not only World War II, but the very essence of war as such, according to Clausewitz – violence as a way of compelling an enemy to do our will. Partisan war can be viewed as a method of wearing out enemy forces without decisive battle, but it provokes terror upon civilian population and becomes more violent and bloody than conventional war. Clausewitz views it as a last resort for government at war. Klimov’s film approaches Clause­witz’s theory not only in evaluation of partisan warfare, but also in the main ethical idea: both belong to the tradition of realism, which views military violence through expediency. In military situation, violence is not immoral per se, but is considered to be moral or im­moral according to its expediency, i.e. the balance of results it achieves and of number of victims and collateral damage. Both Klimov and Clausewitz oppose not war itself, but mili­tarism, i.e. attempts to glorify and romanticize it.
Our Common Post-Covid-19 Pandemic Future: A Return to “Normal” or a Creation of the New “Normal”?
Authors:   College of the Holy Cross, Cicovacki Predrag , Lima Natacha Salomé ,   National Scientific and Technical Research Council
Published: July 2022

The goal of this paper is to reflect on our common post-Covid-19 future. To do so, we first examine our present pandemic situation in terms of the pairs of the correlated concepts: peace and war, and the normal and the abnormal. We then proceed to analyze the dual aspect of the concept of normal: its descriptive as well as its normative side. In doing so, we con­sider the ethical views of Immanuel Kant, Nicolai Hartmann, Fritz Jahr, and Paul Ricoeur; their views help but do not lead to the solution we find satisfactory. Upon further examina­tion, we come to the realization that our problems with understanding our present and with anticipating our future seem to be ultimately related to our struggle to establish a ground on which both the descriptive and normative aspects of the concept of “normal” can be satisfac­torily founded. Our suggestion is that this problem may be solved by understanding what is normal in terms of health, understood as balance and as finding a proper measure in every­thing we do. Our common post-Covid-19 future should be centered on our renewed commit­ment to the promotion of physical and mental, as well as individual, social, and environmen­tal health. We thus set a stage for further development of an ethics of health.