bluuebunny/crossref_metadata_2025 huggingface dataset:
Hubungan Alel Human Leukocyte Antigen A*11 dengan Kejadian Karsinoma Nasofaring pada Etnik Minangkabau di RSUP Dr. M. Djamil Padang
Authors: Tri Yuspitasari Jenny , Rahman Sukri , Hafiz Al
Published: December 2023

Latar Belakang : Karsinoma nasofaring (KNF) merupakan keganasan sel skuamosa nasofaring yang etiologi dan epidemiologinya dipengaruhi oleh etnik di dunia.  Etiologi KNF bersifat multifaktorial yaitu interaksi antara infeksi virus Epstein-Barr (EBV), faktor lingkungan dan faktor genetik. Human Leukocyte Antigen (HLA) merupakan alel yang berperan penting dalam presentasi antigen virus yang menentukan dampak respon imun terhadap infeksi  EBV. HLA bersifat polimorfisme dan sangat bervariasi pada etnik yang berbeda. Hal ini dapat dilihat dengan ditemukannya hubungan antara alel HLA dengan kejadian KNF. HLA-A*11 diduga berhubungan dengan insiden KNF yang rendah karena kemampuan alel tersebut memicu sistem imun dalam melawan virus. Tujuan : Mengetahui hubungan antara HLA-A*11 dengan kejadian KNF pada etnik Minangkabau di RSUP Dr. M. Djamil Padang. Metode : Penelitian analitik dengan menggunakan desain potong lintang (cross sectional),  dilakukan terhadap 18 pasien KNF etnik Minangkabau  dan 18 orang sehat etnik Minangkabau sebagai kontrol. Pada responden dilakukan pemeriksaan molekuler untuk melihat ekspresi HLA-A*11 dengan metode PCR-SSP (Polymerase Chain Reaction-Sequence Spesific Primer). Data dianalisis secara statistik dengan program komputer dan dinyatakan bermakna jika p <0.05. Hasil : Pada penelitian ini frekuensi HLA-A*11 ditemukan lebih banyak pada pasien kontrol (77,8%) dibandingkan dengan pasien KNF (66,7%), akan tetapi secara statistik tidak bermakna (p>0.05) Kesimpulan : Tidak terdapat hubungan Alel HLA-A*11 dengan kejadian karsinoma nasofaring pada etnik Minangkabau.
Konsumsi Ikan Asin Meningkatkan Risiko Kanker Nasofaring: Tinjauan Sistematik dan Meta-analisis
Authors: MUNAWIR AL , Dika Pangestu Yusufa , Indreswari Laksmi
Published: December 2023

Latar Belakang: Kanker nasofaring atau sering disebut sebagai KNF adalah penyakit keganasan sel skuamosa pada lapisan epitel nasofaring. Konsumsi makanan diawetkan menyumbang persentase tertinggi penyebab KNF sebesar 35,5%, salah satu makanan diawetkan adalah ikan asin. Terdapat perbedaan pendapat di antara studi-studi yang ada mengenai pengaruh konsumsi ikan asin terhadap risiko kanker nasofaring. Beberapa studi menunjukkan adanya peningkatan risiko, sementara studi lainnya menyatakan bahwa konsumsi ikan asin tidak memiliki pengaruh signifikan terhadap kejadian kanker nasofaring. Tujuan: membuktikan konsumsi ikan asin meningkatkan risiko kanker nasofaring. Metode: Tinjauan sistematik dan meta-analisis. Hasil; Dari enam studi, lima studi menunjukkan hasil yang signifikan dan satu studi menunjukkan hasil yang tidak signifikan. Hasil meta-analisis didapatkan nilai p<0,00001 dan crude OR sebesar 1,65. Kesimpulan: Konsumsi ikan asin lebih dari tiga kali dalam satu bulan dapat meningkatkan risiko kanker nasofaring sebesar 1,65 kali.

Background: Nasopharyngeal cancer, often referred to as NPC, is a disease of squamous cells on the epithelial layer of the nasopharynx. Consumption of foods contributed to the highest percentage of KNF causes at 35.5%, one of the foods consumed was salted fish. There are differences of opinion between existing studies on the influence of salted fish consumption on the risk of nasopharyngeal cancer. Some studies indicate an increased risk, while other studies state that salted fishing has no significant influence on the incidence of nasopharynx cancer. Objective: Prove that the consumption of salted fish increases the risk of nasopharyngeal cancer. Methods: Systematic review and meta-analysis. Results; Out of six studies, five studies showed significant results and one study showed insignificant results. The meta-analysis resulted in a p<0,00001 and a crude OR of 1.65. Conclusion: Consumption of salted fish more than three times in a month can increase the risk of nasopharyngeal cancer by 1.65 times.
Effects of Infill Panels with Various Configurations on the Non-Linear Dynamic Responses of Reinforced Concrete Structures
Authors: Mohamad Maysam N. , Mohamad Halla J. , Mahmood Mohamad N.
Published: December 2023

Abstract: This study presents the effects of including infill panels on the non-linear dynamic response of a hypothetical reinforced concrete frame when subjected to an earthquake. Infill panels are represented by equivalent diagonal struts using three different configurations, i.e., single, double with three different connection locations with the beams, and triple struts. The main goal is to determine the simplest and most appropriate representation of the infill panels by analogous struts. The effect of panel sizes on the non-linear dynamic response of the structure is also presented in this work. The main results showed that including infill panels in the analysis reduced the natural period, roof displacement, and story drift ratio, increasing the roof acceleration and shear forces at the structure base. Utilizing the triple model and the double strut joined at the midspan of the beams showed a good agreement with those using the complete infill model.
Reações adversas do tratamento da tuberculose em pacientes atendidos em uma unidade de saúde no interior da Amazônia
Authors: Costa Verônica dos Santos da , Silva William Rafael de Farias , Martins Nádia Vicência do Nascimento , Takanashi Silvania Yukiko Lins , Sousa Giovana Andreia Gibbert de , Souza Juarez de
Published: December 2023

Objetivo: Analisar ocorrências de reações adversas relacionadas ao tratamento da tuberculose e sua associação com variáveis clínicas e desfecho em uma cidade no interior da Amazônia. Métodos: Trata-se de um estudo transversal, descritivo e documental, no qual foram analisados 90 prontuários de pacientes com tuberculose atendidos em uma unidade de saúde entre os anos de 2015 e 2022. Foram coletados dados sobre o perfil sociodemográfico, características clínicas e desfecho dos pacientes por meio de uma ficha elaborada pelos pesquisadores. Resultados: A maioria dos pacientes eram do sexo masculino, na faixa etária de 45 a 59 anos, solteiros, pardos e procedentes de Santarém. Houve prevalência de tuberculose pulmonar. A maioria dos pacientes (90%) apresentaram reações adversas ao tratamento. Prevaleceu os efeitos adversos menores (78,3%) com destaque para os gastrointestinais. A maior parte obteve a cura da doença (60%); 15,6% evoluíram a óbito; 13,3% ainda estavam em tratamento; 7,8% não concluíram o tratamento devido abandono. Conclusão: Conclui-se que as ocorrências de reações adversas, na sua maioria, foram de menor gravidade, como epigastralgia, náuseas, vômitos, dor articular, cefaleia e prurido leve, sem grandes repercussões para o paciente e tratamento, sendo manejadas apenas com orientações gerais e sintomáticos.
Percepção de estudantes universitários de uma instituição pública sobre a psoríase e nutrição
Authors: Silva Maria Lays Fonseca da , Soares Valéria Leite , Lima Rafaela Lira Formiga Cavalcanti de , Callou Kátia Rau de Almeida
Published: December 2023

Objetivo: Avaliar o conhecimento e comportamento de estudantes do Centro de Ciências da Saúde de uma universidade pública brasileira sobre a psoríase e nutrição. Métodos: Estudo transversal quanti-qualitativo com 218 estudantes, sendo 76 de nutrição e 142 de outros cursos. Formulários estruturados desenvolvidos no Google Forms® foram enviados aos participantes pela rede social WhatsApp®. Dados quantitativos foram representados em distribuição de frequência e os qualitativos, processados no Software IRAMUTEQ, por meio da nuvem de palavras e análise de Similitude. Resultados: Dos estudantes, 8,2% relataram ser a doença contagiosa; 36,6% desconheciam a sua frequência e 9,1% responderam que a doença não possui tratamento. Sentimentos de tristeza, susto/espanto, algo muito ruim e nojo foram relatados pelos estudantes ao visualizarem fotografias de psoríase. Dos comportamentos estigmatizantes, 18,34%, 23,85% e 36,69% relataram dúvida se aceitariam alimento preparado por um indivíduo com psoríase, se entrariam em uma piscina e se namorariam indivíduo com psoríase, respectivamente. As principais orientações nutricionais foram: alimentação equilibrada; consumo adequado de água, frutas, fibras, alimentos integrais; evitar alimentos processados, ultraprocessados e estimular dieta rica em compostos antioxidantes. Conclusão: A psoríase apresenta características desconhecidas pelos estudantes, os quais relataram comportamentos estigmatizantes e orientações nutricionais inespecíficas para o tratamento da doença.
Comparação do desempenho entre índices de adiposidade abdominal e global como discriminadores da doença renal crônica
Authors: Carvalho Wágner do Nascimento , Tonaco Luís Antônio Batista , Moreira Alexandra Dias , Velasquez-Melendez Gustavo
Published: December 2023

Objetivo: Avaliar o desempenho dos índices de adiposidade - índice de massa corporal (IMC), circunferência da cintura (CC), razão cintura estatura (RCE) e a body shape index (ABSI) - para discriminação da doença renal crônica (DRC). Métodos: Estudo transversal realizado com dados obtidos da Pesquisa Nacional de Saúde 2013, considerando medidas laboratoriais e índices antropométricos aferidos. Dentre os parâmetros avaliados para testar o desempenho dos índices de adiposidade na discriminação da DRC (taxa de filtração glomerular < 60 ml/min/1,73 m²) estão áreas sob a curva (AUC) ROC com respectivos intervalos de confiança (IC 95%) e índices de Youden. As análises foram feitas na amostra total e estratificadas por sexo e faixa etária. Resultados: Os índices de adiposidade (IMC, CC, RCE e ABSI) mostraram poder discriminatório na aleatório para DRC na amostra total e quando estratificado por sexo e faixa etária, mas a RCE demonstrou melhor desempenho em relação a AUC em todas as análises (0,653 na amostra total, 0,663 no sexo masculino, 0,649 no sexo feminino, 0,606 nos adultos e 0,549 nos idosos). Conclusão: Este estudo demonstrou que os índices de adiposidade apresentam baixo poder discriminatório para DRC, embora significativo.
The Organization of Turkic States and Post-Colonialism in Central Asia: Possible Contributions, Prospects, and Limitations
Authors: Dosbolov Abzal , Sönmez Göktuğ
Published: December 2023

This paper explores the Organization of Turkic States’ (OTS) support in aiding Central Asian republics to address their historical legacies, focusing on the period following Russian influence from the 18th century. Employing a postcolonial theoretical lens, it examines the post-independence phase of these republics, highlighting the OTS’s role in promoting regional cooperation, cultural revitalization, and social unity. The paper discusses the challenges faced by these nations in various sectors such as economics and linguistics, assessing the OTS’s capacity to support their development, given its resources and relative position amidst other significant regional entities. Additionally, it delves into broader regional developmental strategies and their implications for the OTS’s objectives. The paper underscores the importance of strategic autonomy for Central Asia in the context of evolving regional dynamics. It concludes by recognizing the OTS’s potential in contributing to the region’s progress, presenting a comprehensive view of the intricate regional landscape and the OTS’s part in fostering growth and development in Central Asia.
Effect of chewing betel leaves on salivary pH – A randomized controlled trial
Authors: Subramani Prabhu , Priya M. R. , Rashmika H. , Rajan Reshmi , Naaz Sabiha , Devi R. Sanchana
Published: December 2023

Betel leaves have been described from the ancient time as an astringent, anti-microbial, and anti-oxidant. Saliva plays an important role in the maintenance of good oral health. Sucrose is the most cariogenic dietary carbohydrate, because it is fermentable and also serves as a substrate for the synthesis of extracellular and intracellular polysaccharides in dental plaque. The effect of betel leaves over sugar solution has been least explored. The study aimed at comparing the effect of betel leaves chewing on the salivary pH. A randomized controlled trial was conducted among n = 20 participants. The participants were asked to chew fresh betel leaves for 1 min after taking sugar solution and the pH was assessed at following time intervals baseline, 10, 30, and 45 min, respectively. Chewing betel leaves after intake of sugar solution tends to neutralize salivary pH within 10 min after consumption, thereby reducing the acid attack on the tooth surface by plaque bacteria. Betel leaves are effective in neutralizing the salivary pH after intake of sugar solution; therefore, it is suggested to consume plain betel leaves after a meal to neutralize the salivary pH and, thus, reduce the acid attack on the tooth which causes demineralization.
Management of uterine fibroid with homoeopathy: A case report
Authors: Maiti Bishnu Prasad , Khadim Azizul Islam , Jamatia Shimul
Published: December 2023

In women of reproductive age, uterine fibroids (UF) are among the most prevalent benign tumours. A female patient of 35 years of age presented with complaints of irregular, profuse menstrual flow with dull, aching pain in the whole abdomen during menses, having previously been diagnosed as ‘Uterine fibroid’ for one year. Homoeopathic medicine was prescribed on the basis of the totality of symptoms which restored the patient’s health. Initially, Calcarea carbonica 200C was given, and later, the potency was increased to 1M. Rhus Toxicodendron 30C was prescribed during the course of treatment for viral fever. The assessment of significant improvement was done using UF symptoms and a health-related quality of life questionnaire every three months. The Modified Naranjo Criteria for Homoeopathy (MONARCH)-causal attribution inventory was also used to evaluate the response of homoeopathic medication and further clarify the importance of individualised treatment in homoeopathy. This case study demonstrates the value of individualised homoeopathic treatment in the treatment of UFs.
A case of viral hepatitis C treated with homoeopathy
Authors: Purohit Hitesh G. , Dodiya Khyati , Tadvi Ravina
Published: December 2023

The individual’s susceptibility helps keep the disease at bay; when the vital force alters normal body function also gets disturbed, which results in altered susceptibility and lowered immunity. It affects not only physiological function but also affects the mind. This case report demonstrates the evolution of the patient’s core and illness. It demonstrates the importance of understanding the pathogenesis of the disease and the role of symptom classification, selection of characteristic symptoms, repertorisation, and materia medica differentiation in the process of arriving at the right remedy.
Suicides of elite Japanese writers: The case of Ryunosuke Akutagawa
Authors: KANTHA SACHI SRI
Published: December 2023

Background

. To mark the 130th birth anniversary of Japanese writer Ryunosuke Akutagawa (1892–1927), I revisit his suicide (as recorded by his hand) in comparison to that of his junior contemporaries, who also chose a similar mode of death.

Data sources

. Two works of Akutagawa, namely Tenkibo (1926: Death Register) and Aru Ahono Issho (1927: The Life of a Stupid Man) in English translation of Jay Rubin were used as the main sources, in addition to published literature about his creativity.

Results

. In his final work, The Life of a Stupid Man, completed in the penultimate month before suicide, 7 among the 51 brief descriptions, Akutagawa had described his thoughts on illness and death, in addition to visiting his biological mother in a lunatic asylum, and studying a cadaver for his famous short story ‘Rashomon’. These descriptions offer a fascinating perspective on Akutagawa’s state of mind, before his suicide. Akutagawa’s suicide is also compared with the suicides of five other renowned Japanese writers (Osamu Dazai, Yasunari Kawabata, Misuzu Kaneko, Yukio Mishima and Juzo Itami).

Conclusion

. Before his suicide, doctors offered Akutagawa various diagnoses: ‘insomnia, gastric hyperacidity, gastric atony, dry pleurisy, neurasthenia, chronic conjunctivitis, brain fatigue’. Though it is uncertain, what percentage of hereditary factor(s) played a role, why the practitioners of the medical profession in 1920s Japan failed to save the life of this creative individual still remains a question.
Publication requirement for faculty promotion in medical institutions in India: ‘Mind the gap’
Authors: CHHAVI NANDA , SRIVASTAVA GEETIKA , GOEL AMIT , AGGARWAL AMITA
Published: December 2023

Background

. We assessed the balance between the number of publications required by medical teachers and the publication space available in the Indian medical journals.

Methods

. The Medical Council of India (MCI) website, its guidelines and documents were searched and we extracted data on the number of medical colleges, undergraduate and postgraduate seats and faculty requirement. The required number of assistant professors and associate professors was calculated. The publication requirements were estimated according to MCI’s February 2020 guidelines. A publication which satisfied the above guidelines for promotion was counted as ‘eligible publication’. Indian medical journals indexed in any of the MCI-permitted databases were identified, and the number of eligible articles in them in 2019 was counted.

Results

. India has a total of 79 798 MBBS seats, 33 025 postgraduate seats and 4231 superspecialty seats in MCI-certified medical institutions and to teach them 35 285 assistant professors and 23 116 associate professors are required. Assuming that each publication could serve a maximum of 3 teachers, we will need approximately 50 696 eligible publications in the next 7 years. A search of applicable databases, identified 162 unique Indian medical journals of which 79 were indexed in PubMed/PubMed Central. Among the remaining 63 were indexed in DOAJ, 14 in EMBASE, 3 in Scopus and 3 were indexed only in WOSSCIE. These journals cumulatively published a total of 8508 eligible publications in 2019.

Conclusion

. The publication space in Indian medical journals is limited, thus there is a need to have a national medical repository such as MedRxiv to prevent publication in predatory journals.
Seawater quality assessment of the marine ecosystem of Punta Galeta in Panama
Authors: Guerra-Chanis Gisselle Esther , Latta Dalvis , Broce Kathia
Published: December 2023

Seawater quality was described in the Caribbean coast of Panama based on water physicochemical parameters and biological monitoring studies. Samples of water and benthic macroinvertebrates were collected near Punta Galeta, Province of Colón, Panama. The sampling area was sheltered from the action of waves and located between the coral reef and mangroves. Class Polychaeta was themost abundant with 90 % overall presence in Punta Galeta. Taxonomic classes of Bivalvia, Malacostraca and Ophiuroidea only represented 10 % altogether. Overall, seawater quality was suitable for the collected species of macroinvertebrates, even though concentrations of nitrateand phosphate were above the recommended value. Recorded values of temperature, pH and dissolved oxygen indicated that the site is far from reaching hypoxic conditions. Water quality index indicates a good water quality at Punta Galeta. Further studies with more robust and intense sampling programs are required to properly define the seasonal variations of water quality and its link to benthic macroinvertebrates. Similar studies in the Caribbean of Panama are scarce even though they offer valuable information for water resource administrators.
Morfodinámica de una playa tropical macromareal: La Bocana, Costa Pacífica de Colombia
Authors: Ricaurte-Villota Constanza , Coca Domínguez Oswaldo
Published: December 2023

Este estudio analiza la morfodinámica de la playa La Bocana en el Pacífico tropical colombiano, en un régimen macromareal. Los datos se tomaron con un sistema de posicionamiento global diferencial para generar modelos digitales de elevación y perfiles de playa entre 2014 y 2019. Posteriormente, se realizó una clasificación morfodinámica utilizando los parámetros de velocidad de caída adimensional y amplitud relativa de las mareas. Los resultados indican que los tipos de playa predominantes fueron dominados y modificados por la marea: tipo disipativas (modificadas por mareas, dominadas por mareas y erosivas) e intermedias (modificadas por mareas y no erosivas). Se observaron perfiles reflectantes frente a la playa (época erosiva) en 2014 y 2015. A pesar de que la playa estudiada se localiza en el trópico, los resultados no difieren con los propuestos para playas de latitudes medias. Los resultados sugieren el dominio del rango mareal en la determinación de los estados morfodinámicos de la playa. Este estudio muestra que la playa La Bocana tiene diferentes estados morfodinámicos espacio-temporales, es decir que no existe un único estado de playa representativo. 6 años de datos muestran variaciones intranuales (estacionales) o bajo ciertas condiciones ambientales (relacionadas con El Niño), las cuales cambian significativamente las playas.
Arribo masivo de sargazo (Sargassum natans) a la costa del Caribe Sur de Costa Rica durante el 2022.
Authors: Piedra-Castro Lilliana , Ramírez-Vargas Marco Antonio
Published: December 2023

A inicios de marzo del 2022, se dio un evento de llegada masiva de sargazo (Sargassum natans) a diferentes playas del Caribe Sur de Costa Rica. Aunque la presencia de esta alga parda no es rara en la costa Caribe del país, la magnitud del material acumulado es atípica. La localidad de Puerto Viejo fue la más afectada, llegando a acumularse hasta 676.34 m3 de material en 100m de playa. El sargazo acumulado afectó especialmente a pescadores artesanales quienes tuvieron dificultad para llevar sus embarcaciones al mar y a operadores turísticos quienes vieron afectada la estética de las playas. La llegada masiva de sargazo al Gran Caribe afecta ya los modos de vida de diferentes países. En Costa Rica es un evento reciente pero que tiene potencial para afectar ambiental y socio-económicamente toda la costa Caribe. Es necesario la articulación de instituciones y sociedad civil para el monitoreo y la alerta temprana de futuros eventos.
Fungal Endophytes Isolated From Mangroves In San Pedro Nature Reserve, Buenaventura
Authors: Osorio Jhon alexander
Published: December 2023

Los manglares ofrecen una variedad de servicios económicos, ecológicos y culturales. Sin embargo, a pesar de su importancia y la diversidad que estos albergan, las actividades antrópicas han contribuido a su deterioro. Los estudios sobre hongos endófitos asociados a ecosistemas de manglares aún son limitados en Colombia. Este grupo de hongos incluye una amplia variedad de patógenos oportunistas a menudo asociados con árboles afectados por actividades ambientales y antropogénicas. Con el fin de contribuir al conocimiento de la diversidad de hongos endófitos asociados a árboles de mangle en la Reserva Natural San Pedro, Buenaventura, Colombia, se colectaron ramas (longitud aprox. 10 cm) de Laguncularia racemosa, Mora oleifera, Pelliciera rhizophorae y Rhizophora racemosa para los respectivos aislamientos fúngicos. Se extrajo ADN y se amplificó la región del espaciador transcrito interno (ITS), seguido de análisis filogenéticos tales como Bayesiano (BI), Máxima Verosimilitud (ML) y Máxima Parsimonia(MP). En total se reconocieron nueve géneros, Bipolaris, Ciboria, Coprinellus, Cylindrobasidium, Epicoccum, Fusarium, Lasiodiplodia, Neofusicoccum y Neurospora pertenecientes a ocho familias. De estos, Fusarium, Lasiodiplodia, Neofusicoccum son bien conocidos por su alto potencial para amenazar la salud de sus huéspedes. Los resultados sugieren que los manglares constituyen un ambiente poco explorado para el estudio de diferentes grupos de hongos asociados.
“Catherine’s Korans” in the National Library of Russia
Authors: Likhomanov Anton V.
Published: December 2023

The article for the first time investigates in detail the issue of two copies of the socalled “Catherine’s Korans”, kept in the National Library of Russia (NLR). More than 7 thousand copies were published in St. Petersburg in 1787—1797. It was the world’s first example of a printed Koran, prepared in accordance with Muslim traditions. These books were published after vast territories with Muslim population were adjoined to Russia, which was of great political importance. The article examines the Koran, which was received by the NLR from the Imperial Hermitage Foreign Library at the end of 1861 — the beginning of 1862, and for the first time introduces information about the Koran belonging to the famous bibliophile General P. Sukhtelen, which came to the NLR in 1836. On the basis of comparing of two copies of the Koran it is concluded that the holy book of Muslims from Sukhtelen’s library belongs to an earlier edition than the Koran from the Imperial Hermitage Foreign Library.
Problems of forming the social picture of a civil servant
Authors: Yakovleva O. S. , Emelyanov M. A.
Published: December 2023

The article is devoted to the study of the formation of ideas about the image of a civil servant in the perception of society (population), the picture (image) of a civil servant and a government authority, as well as the problem of its formation. The formation of a social portrait or picture (image) of a civil servant and a government authority as a whole in the perception of the public has been an urgent issue since the early 2000s following the implementation of «strengthening the vertical of power» reforms. It is essential to recognise that any image requires effective management to ensure a favourable public perception. To create a favourable social perception of a civil servant, it is crucial to establish a set of measures for their formation. The civil service is a social institution, has a public character, and the formation of its image depends on the manageability of this process. Sometimes citizens do not have the opportunity for personal contact with civil servants, leading them to perceive civil servants based on media, social networks, and messengers. Unfortunately, this often results in negative perceptions. Examining the sources from which society draws knowledge and forms the image of civil servants and the civil service is essential.
Classification of special legal means of ensuring environmental safety during subsoil development in the Arctic zone of Russia
Authors: Yakovleva T. A.
Published: December 2023

In order to assess the legal regulation in the sphere of ensuring environmental safety in the development of subsoil in the Arctic zone of Russia, the system is investigated and the classification of special legal means provided by the legislation on subsoil and environmental protection is developed. Based on the analysis of the legal definition of «environmental safety», two groups of special legal means are singled out: 1. prevention of negative impact on the environment; 2. liquidation of consequences of negative impact on the environment. The methodological basis of the study was general scientific and private legal methods. The system of special legal means of ensuring environmental safety in subsoil development regulated by the legislation requires its further development, in particular, the legislation does not define the procedure for environmental certification, there is no legal regulation of the implementation of environmental audit as a measure aimed at reducing the negative impact of economic activity on the environment. The rules of land reclamation do not have special norms aimed at restoring the natural environment after the development of mineral deposits. It is proposed to change the approach to the solution of the mentioned issue through the restoration of the natural landscape. Landscape reclamation will be the foundation for the renewal of the disturbed ecosystem after mining.
ORGANIZATION MECHANISMS OF CREATING CO-OPERATIVE SOCIETIES TO ENSURE REGIONAL FOOD SECURITY
Authors: Яшкова Н.В. , Каспаров И.В. , Чумаков В.Н.
Published: December 2023

Вопросы продовольственной безопасности и продовольственной независимости как отдельного региона, так и страны в целом являются наиболее важными и стратегическими вопросами экономической безопасности страны. В статье приведена авторская трактовка указанной экономической категории, отражающая тип кооперации, ее цели и задачи, детализирующая участников кооперации, и что самое главное в предложенном определении прослеживается взаимосвязь кооперации и продовольственной безопасности. Критический анализ имеющихся методик определения паевого капитала кооператива позволил авторам внести корректировки в предложенную ими ранее методику формирования паевого капитала и усовершенствовать ее.

The issues of food security and food independence of both a single region and a country as a whole are the most important and strategic issues of national economic security. We present our own interpretation of the economic category in question reflecting the type of cooperation, its goals and objectives, specifying the participants of cooperation, and most importantly, the proposed definition traces the relationship between the cooperation and food security. Critical analysis of the current methods of defining cooperative’s equity capital enables us to correct our own methodology of its formation and thus improve it.
ON PUBLIC DANGER OF ILLEGAL ENTREPRENEURSHIP
Authors: Бычков С.Н. , Семенов К.П.
Published: December 2023

В статье проанализирована структура объекта незаконного предпринимательства, а также обосновано утверждение об общественной опасности этого деяния как одного из признаков преступления, характеризующего его материальное содержание. Общественная опасность как признак преступления авторами исследована в контексте аргументированности факта наличия этого признака в преступлении, ответственность за которое предусмотрена ст. 171 «Незаконное предпринимательство» Уголовного кодекса Российской Федерации (УК РФ). Обращено внимание на то, что общественную опасность незаконного предпринимательства следует рассматривать не абстрактно, в качестве модели, установленной законодателем, а через потенциальную опасность определенных деяний (деятельности без регистрации, лицензирования, аккредитации), понимая при этом общественную опасность непосредственно как опасность, то есть возможность причинения вреда общественным отношениям. Авторами проведена аналитическая работа по изучению различных подходов в контексте обоснованности и достаточности объективно существующей общественной опасности незаконного предпринимательства. Результатом этой работы стал вывод о недостаточности обоснованности и аргументации признака общественной опасности незаконного предпринимательства, необходимого для его криминализации.

The article presents analysis of the structure of the object of illegal entrepreneurship and the public danger thereof as one of the signs of crime characterizing its material content. The public danger as an element of a crime is studied by the authors in the context of the validity and justification for the presence of this element in a crime which entails responsibility provided for by Art.171 of the Russian Criminal Code «Illegal Enterprise». The authors point out that the public danger of illegal entrepreneurship should not be considered abstractly as a model established by the law makers but through potential danger of particular deeds (business activities without registration, or without a license, or without accreditation). Wherein the public danger is understood directly as a threat that might cause harm to public relations. The authors carried out an analytical research aimed at the study of different approaches to assess validity and sufficiency of existing public danger of illegal entrepreneurship. The study has resulted in the conclusion about insufficient validity and justification for the sign of public danger of illegal entrepreneurship necessary to criminalize the one.
INVESTIGATIVE EXPERIMENT IN THE SYSTEM OF INVESTIGATIVE ACTIONS
Authors: Рамазанов Р.А.
Published: December 2023

В статье рассмотрены особенности производства следственного эксперимента, его значение, отличие от других схожих следственных действий, осуществляемых в рамках расследования уголовного дела. Раскрыты особенности и порядок проведения следственного эксперимента на разных стадиях уголовного процесса.

The article discusses specific features of conducting investigative experiment, its significance, and its difference from other similar investigative actions carried out as part of a criminal investigation. The features and procedure for conducting an investigative experiment at various stages of the criminal process are considered.
MODEL OF EFFECTIVE DEVELOPMENT OF INDUSTRIAL ENTERPRISE UNDER LIMITED RESOURCES
Authors: Шитиков И.Е. , Демиденко Д.С. , Малевская-Малевич Е.Д.
Published: December 2023

Выявлены основные отличительные особенности современной экономики в контексте управления развитием промышленного предприятия. Рассмотрены наиболее характерные для современной экономики ограничения возможностей развития промышленных предприятий. Предложена эконометрическая модель эффективного развития промышленного предприятия с учетом выявленных ограничений, характерных для экономики устойчивого развития.

We reveal the key particular features of modern economy in the context of managing the development of an industrial enterprise. We consider the most characteristic for the modern economy restrictions for the development of industrial enterprises. We offer an econometric model of effective development of an industrial enterprise considering the restrictions revealed that are typical for the economy of sustainable development.
DIVERSIFICATION OF NATURAL GAS MONETIZATION CHANNELS ON YAMAL PENINSULA
Authors: Шорохов А.Н.
Published: December 2023

Статья посвящена вопросам дальнейшего развития газодобывающего бизнеса полуострова Ямал, а именно поиску потенциальных альтернативных каналов поставок природного газа в условиях ограничений поставок по трубопроводному транспорту. Информационная база исследования включает содержание электронных ресурсов нефтегазодобывающих компаний и государственных органов. По результатам проведенных исследований предложено рассмотреть три варианта диверсификации поставок природного газа для основных нефтегазодобывающих компаний на полуострове Ямал с целью разработки своих внутренних стратегий развития в рассматриваемого регионе.

The article is focused on further development of gas production business on the Yamal Peninsula, to wit, on the search for alternative channels of natural gas monetization under limitations of pipeline transportation. The related research information base includes the content of the digital resources of oil and gas production companies as well as the ones of the government agencies. Based on the results of the researches conducted there have been developed and proposed for consideration three diversification options concerning natural gas monetization for major oil and gas production companies on the Yamal Peninsular with the aim of developing their own inner strategies of the development in the region under consideration.
Empleo de la harina de Brassica oleracea en la alimentación de pollos de ceba
Authors: Quishpe  Mendoza Xavier , Silva Deley Lucía , Chacón Marcheco Edilberto , Toro Molina Blanca , Garzon Jarrin Rafael
Published: December 2023

El incremento de las materias primas para producir alimentos balanceados encarece en la actualidad la producción animal. El objetivo de este trabajo fue determinar la composición química de la harina de brócoli (Brassica oleracea), así como la respuesta productiva en pollos de ceba al incluirla en su ración. Se realizó una investigación experimental y se empleó el método deductivo. Se determinó la composición química de la planta, y las variables productivas en los animales. La harina mostró altos porcentajes de proteína. Los indicadores productivos reflejaron que al aumentar los días de crianza el tratamiento con 30% de inclusión de la harina fue superior con un peso vivo de 3,17 kg/aves, un consumo de 5,22 y una conversión de 1,64 g/kg, así como, no ocurrieron muertes (100% de viabilidad). La inclusión de la harina de brócoli hasta el 30% no afectó los indicadores productivos, y disminuyó los decesos en las aves.
Understanding the Origins of Reversible and Hysteretic Pathways of Adsorption Phase Transitions by Mesocanonical Ensemble Monte Carlo Simulations
Authors: Parashar Shivam , Neimark Alexander V.
Published: December 2023

Phase behavior of nanoconfined fluids adsorbed in metal-organic frameworks is of paramount importance for the design of advanced materials for energy and gas storage, separations, electrochemical devices, sensors, and drug delivery, as well as for the pore structure characterization. Phase transformations in adsorbed fluids often involve long-lasting metastable states and hysteresis that has been well-documented in gas adsorption-desorption and nonwetting fluid intrusion-extrusion experiments. However, theoretical prediction of the observed nanophase behavior remains a challenging problem. The mesoscopic canonical, or mesocanonical, ensemble (MCE) is devised to study the nanophase behavior under conditions of controlled fluctuations to stabilize metastable and labile states. Here, we implement the MCE Monte Carlo (MCEMC) simulation scheme, called the gauge cell method, which allows to produce van der Waals type isotherms with distinctive swings around the phase transitions regions. The constructed isotherms determine the positions of phase equilibrium and spinodals, as well as the nucleation barriers separating metastable states. The MCEMC method is applied to predict the origins of reversible and hysteric adsorption phase transitions in a series of practical MOF materials, including IRMOF-1, ZIF-412, UiO-66, Cu-BTC, IRMOF-74-V, VII, and IX. We demonstrate the unique capabilities of the MCEMC method in quantitative predictions of experimental observations compared with the conventional grand canonical and canonical ensemble simulations. The MCEMC method is implemented in the open-source RASPA software and recommended for studies of adsorption behavior and pore structure characterization of MOFs and other nanoporous materials.
Membrane-Free Electrochemical Production of Acid and Base Solutions Capable of Processing Ultramafic Rocks
Authors: Charnay Benjamin , Chen Yuxuan , Agarwal Rishi , Misleh Jason , Wright Gage , Sauve Ethan , Toh Wei Lun , Surendranath Yogesh , Kanan Matthew
Published: December 2023

Chemical transformations that are effected by sequential addition of acid and base can be performed in closed-loop processes powered by electricity if the acid and base are produced electrochemically from water. Conventional methods of electrochemical acid-base production utilize ion exchange membranes (IEMs) to inhibit proton (H^+) and hydroxide (OH^–) recombination, but these components lead to high resistive losses, low current densities, and poor tolerance for polyvalent metal ions, which compromise energy efficiency and scalability. Here we use an ion transport model to guide the design of an acid-base co-generating system that inhibits recombination via competitive transport of the supporting electrolyte and masking H^+ as HSO4^–, which enables the use of a simple porous separator instead of IEMs. Using the H2 oxidation reaction (HOR) and H2 evolution reaction (HER) for H^+ and OH^– production, we demonstrate steady-state co-generation of acid and base solutions at useful concentrations in the presence of polyvalent impurities with lower energy demand and higher current density than state-of-the-art reported IEM-based systems. Cells can be stacked by combining HER and HOR electrodes into a bipolar gas diffusion electrode, which recirculates H2 with near-unity efficiency. The acid and base outputs of the cell are capable of extracting alkalinity from olivine and serpentine in the form of Mg(OH)2 and Mg(OH)2 * 2 MgSiO3, which are shown to be competent for removing CO2 from dilute streams to form Mg carbonates.
S.O.S: shape, orientation and size tune solvation in electrocatalysis
Authors: serva alessandra , Pezzotti Simone
Published: December 2023

Current models to understand the reactivity of metal/aqueous interfaces in electrochemistry are based on the adsorption free energies of reactants and products, e.g. volcano plots. Theory, in particular electronic calculations, played a major role in the quantification and comprehension of these free energies in terms of the interactions that the reactive species form with the surface. However, also solvation free energies come into play in two ways: (i) by modulating the adsorption free energy together with solute-surface interactions, as the solute has to penetrate the water adlayer in contact with the surface and get partially desolvated (which costs free energy); (ii) by regulating transport across the interface, i.e. the free energy profile from the bulk to the interface, which is strongly non-monotonic due to the unique nature of metal/aqueous interfaces. Here, we use constant potential Molecular Dynamics to study the solvation contributions and we uncover huge effects of the shape and orientation (on top of the already known size effect) of the solute on its adsorption free energy. We propose a minimal theoretical model, the S.O.S. model, that accounts for size, orientation and shape effects. These novel aspects are rationalized by recasting the concepts at the base of the Lum- Chandler-Weeks theory of solvation into a layer-by-layer form, where the properties of each interfacial region close to the metal are explicitly taken into account.
Highly modular PDMS microwave-microfluidic chip reactor for MAOS applications
Authors: Vázquez-Amaya Laura Y. , Martinic Matko , Nauwelaers Bart , Van der Eycken Erik V. , Markovic Tomislav , Sharma Upendra K.
Published: December 2023

In this work, we introduce a microfluidic chip reactor based on a Complementary Split Ring Resonator (CSRR) for conducting microscale microwave-assisted organic synthesis (MAOS). This microwave-microfluidic chip reactor (µw-µf-CR) is easy to assemble and highly customizable, featuring interchangeable flow cells fabricated on inexpensive PDMS, providing high levels of versatility in terms of manufacturing and design. Various flow cells were designed and explored, offering internal volumes ranging from 2.82 to 6.48 μL and accommodating flow rates between 5 to 8 μL/min. This allows the reaction to be irradiated within a timeframe spanning from seconds to minutes. Remarkably, our setup design bears the potential to operate across a broad range of frequencies (around 2 or 6-12 GHz). Moreover, it provides controllable and efficient heating, reaching temperatures up to 120°C within seconds with a maximum low input power of 4.4 W. Simulations showed an excellent homogeneous heat distribution throughout the flow cell. The applicability of the µw-µf-CR was demonstrated in several organic reactions, where good yields and short reaction times were observed.
Enantioselective Synthesis of Amino Acids by Photocatalytic Reduction of CO2 on Chiral Mesostructured ZnS
Authors: Cui Yongping , Ai Jing , Li Yuanbo , Han Lu , Duan Yingying , Liu Junhong , Liu Xi , Chen Liwei , Jia Menghui , Chen Jinquan , Chu Chaoyang , Ma Yanhang , Ouyang Tianwei , Che Shunai , Fang Yuxi
Published: December 2023

Reduction and fixation of CO2 in natural systems via solar energy generates diverse products, ranging from small molecules to biomolecules. To date, only a few multicarbon species have been obtained by artificial CO2 photoreduction1-5, especially abiotic photosynthesis of biomolecules with various functional groups, which has long been a fundamental yet challenging issue. Herein, we report the photocatalytic synthesis of amino acids from CO2 and NH3 on a chiral mesostructured ZnS (CMZ) nanosphere, which is constructed by arrays of chiral nanorods. Serine (Ser) is the main component of various amino acids, with an enantiomeric excess (ee) greater than 96% and a total yield of over 30 μmol gcat-1. The Ser formation pathway could be accessed through *OCCO intermediates due to C-C coupling, as demonstrated by experimental data. Chiral-induced spin polarization of CMZ has been speculated to facilitate the separation of photogenerated carriers and the production of stable triplet OCCO. Different activation energies of reduction reactions driven by the spin-polarized electrons in CMZ lead to the formation of enantiomeric amino acids. Our findings will inspire new perspectives in catalytic theory and the formation of chiral biomolecules in artificial synthesis and nature.
A Review Study on Safety and Efficacy on Second Line Anti Tubercular Drugs
Authors: Sreelatha Motimi , Naveena Bachu , Chandra Yadala Prapurna
Published: December 2023

Due to intestinal dysbiosis brought on by second-line anti-tubercular medication therapy, the patient's resistance to MTB appears to have decreased. This is likely due to an impact on immune cell proliferation and autophagic processes. therefore adversely influencing the patients' treatment results. The objectives of review articles are the safety and efficacy on the second line anti tubercular drugs. The results of these review article in the year 2015 to 2020. The conversation of these review article is the safety and efficacy of second line anti tubercular drugs . The discussion of these study about the safety and efficacy on second line anti tubercular drugs . 2016 levofloxacin is a not more safe and less effective because result insufficient control to the tuberculosis patient it adverse events is underactive thyroid. 2020 Ethionamide is a safe and effective for the TB patients. The conclusion of these review study and efficacy of  the second line anti tubercular drugs. The ofloxacin are the most effective and safe when compared to the other second line anti tubercular drugs. In second line anti tubercular drugs the levofloxacin is having the less efficacy when compared to other second line anti tubercular drugs because it is having the adverse effect of the hypothyroidism.   For the treatment of tuberculosis the drugs used are the levofloxacin, kanamycin, etc and these are most commonly used for the prevention of the disease.
Postkolonyalizm: Tarihsel Bir Giriş
Authors: COŞKUNER Ayça
Published: December 2023

Postkolonyalizmin vicdani bakımdan olağanüstü acılara sebebiyet vererek, karşılaştığı kültürleri yok ettiğini dile getiren Robert Young, kitabında kültürel ve siyasi bağlamda sömürgeciliği, hem sömürgeleştiren hem de sömürgeleşen toplumlar olarak diğer çalışmalardan daha kapsamlı bir şekilde incelemiştir. Postkolonyal teorinin ortaya çıkışını Çin, Mısır, Bandung, Latin Amerika, Afrika ve Hindistan'daki sömürge karşıtı hareketler üzerinde inceleyerek bu bölgelerde sömürge karşıtı mücadelelerinin lideri haline gelen Fanon, Gandhi, Guevara, Nkrumah, Mao, Mariategui, Senghor gibi isimlerin çalışmalarını inceleyip, bir tane dahi kadın aktivistin neden isminin duyulmadığını ayrıntılı bir şekilde ele almıştır.
A FEW ASPECTS REGARDING THE ACTIVITY OF TEACHER, COMPOSER AND CONDUCTOR GHEORGHE DANGA
Authors: CAZAN Florinel-Ciprian
Published: December 2023

The history of music talks about many teachers, composers, conductors, but, like any science, it cannot fully cover what was written nor all the personalities in the world of music. In this sense, the current article offers details about one of the titans of Romanian choral music, a great self-taught, who studied only two years at the music academy in Bucharest, but being gifted by God with genius abilities, composed and conducted time for over 30 years with an incomparable lightness. I wanted to bring to light the personality of the great maestro Gheorghe Danga, to reveal more unknown aspects about the course of his artistic life , and to make him much better known in the nationally and internationally in the world of music and beyond.