bluuebunny/crossref_metadata_2025 huggingface dataset:
Results of a comparative study of Nigella Sativa L. Seeds oils composition
Authors: Goryainov S. V. , Khromov A. V. , Bakureza G. , Cesar Esparsa , Ivlev V. A. , Vorobyev A. N. , Abramovich R. A. , Potanina O. G. , Novikov O. O.
Published: May 2020

This article presents results of the chemical composition study of the seeds oils lipid complex of Nigella Sativa L. grown under various geographic conditions. The task of the comprehensive study of the chemical composition of the plant and its individual parts remains relevant due to the wide spectrum of its pharmacological activity.

The aim of this work is a comparative study of the fatty acid composition, a non-saponifiable fraction and the composition of essential oils of Nigella Sativa L. seeds grown in different regions of the world.

Materials and methods. The combination of chromatography-mass spectrometry and 1H-NMR spectroscopy methods made it possible to study the qualitative and quantitative composition of Nigella Sativa L. lipid complex seeds. All the experiments were carried out in accordance with the requirements of the State Pharmacopoeia, 14th Ed, given in the corresponding general pharmacopeial monographs.

Results. Profiles have been established and the content of fatty acids, sterines, triterpene alcohols, essential oils and thymoquinone found out in the lipid complex, has been estimated. The saponifiable portion of the complex is represented by triglycerides (81.7–95.3%), di(3.9–15.2%) and monoglycerides (0.7–4.1%). They mainly contain linoleic (55.8–60.6%), oleic (21.8–24.6%), palmitic (10.0–12.8%), stearic (2.4–3.2 %) and cis-11.14-eicosadiene (2.3–2.6%) acids. In the lipid complex, the contents of sterines and triterpene alcohols were 0.4–0.7%; up to 70% of the fraction was represented by β-sitosterol (22.5–29.2%), cycloartenol (20.1–36.6%) and 24 methylenecycloartanol (9.5–19.9%). In the trace amounts (up to 1.0%), cholesterol has been detected in all the samples. In the lipid complexes, the content of thymoquinone ranged from 0.7 to 2.6%.

Conclusion. A comparative study of the seeds lipid complex of Nigella Sativa L. grown under various geographic conditions, has been carried out. The marker compounds as well as their content standards for determining the authenticity of raw materials (thymoquinone, para-cimen, cis-11.14-eicosadienic acid), have been identified.
Members of the family Lamiaceae Lindl. as sources of medicinal plant raw materials to obtain neurotropic drugs
Authors: Zvezdina Е. V. , Dayronas J. V. , Bochkareva I. I. , Zilfikarov I. N. , Babaeva E. Yu. , Ferubko E. V. , Guseynova Z. A. , Serebryanaya F. K. , Kaibova S. R. , Ibragimov T. A.
Published: May 2020

The aim of this workis to review and analyze the data published in the modern scientific literature obtained in pharmacological, pharmacognostic and pharmacotechnological studies of various types of raw materials obtained from members of the familyLamiaceaeL., which were sources of biologically active substances, pharmaceutical substances, total extracts and the drugs – with a neurotropic activity.

Materials and methods.For the review, we used the information of scientific literature from open and accessible sources of the last twenty years, located in the scientific and technical libraries of institutions, as well as in electronic databases: Elibrary, PubMed, Scopus, Cyberleninka, GoogleAcademy, J-Stage. The search inquiries were: the species of the familyLamiaceae(Russian and Latin), the samples of medicinal plant materials based on them as well as the names of the drugs and biologically active substances obtained from these raw materials.

Results.When working with the sources of scientific information, the main attention was paid to pharmacologic tests performed during the studies on laboratory animals and proving the presence of neurotropic activity in the studied objects – essential oils and extracts from plant raw materials: aqueous, aqueous alcoholic, and methanol ones. It has been established that the potential of the therapeutic and preventive application of pharmaceutical substances and drugs based on the medicinal plant materials obtained from 30 genera members of theLamiaceaefamily, remains unrealized despite the close attention of various researchers.

Conclusion.This review comprised 71 species from 30 genera. Despite the significant level of the previous study presented in the analysis of this publication, an enormous potential of this family’s species remains unexplored. In the future, they can be of both – pharmacognostic and practical interest, in particular, in creation of new medicinal preparations of the neurotropic action based on them.
HPLC methods of fexofenadine quantitative analysis in rabbits’ liver
Authors: Mylnikov P. Yu. , Chernykh I. V. , Shchulkin A. V. , Popova N. M. , Yakusheva E. N.
Published: May 2020

The investigation of pharmacokinetics of marker substrates of carrier protein P-glycoprotein (Pgp, ABCB1-protein) including fexofenadine, is one of the methods of its functional activity evaluation.

The aim of the study was to work out the HPLC methods of the quantitative determination of fexofenadine in rabbits’ liver.

Materials and methods. The quantitative determination of fexofenadine was performed using Stayer chromatographic system (Akvilon, Russia) with UVV 104 ultraviolet detector. Reverse-phased chromatographic column Luna C18 100Å (250*4.6) was used with 5 µm granulation at 45°С. The сoncentration of fexofenadine was determined by methods of absolute peak area calibration.

Results. The work was conducted in the isocratic mode. The composition of the mobile phase consisted of deionized water, acetonitrile and glacial acetic acid at the ratio of 267.4:120:4.33 brought to pH=6.7 with triethylamine. The sample processing was in the form of homogenization of 500 mg of ground liver in 500 µl of purified water with the subsequent centrifugation (1750 g) and selection of the supernatant. The proteins were precipitated by acetonitrile (2.5 ml) acidified with 375 µl of hydrochloric acid by shaking at 500 rev/min. The supernatant was transported into a separate test tube, where methylene chloride, diethyl ether and ethyl acetate were added (2 ml each). Then the solution was again shaken for 10 minutes (500 rev/min). After that, the solution was centrifuged (1750 g) and the supernatant was evaporated on a rotor-vacuum evaporator at 50°С. 300 µl of the mobile phase was added to the dry residue, and 100 µl was injected into the chromatograph. The method was validated in the linear range from 3 to 60 µg/g of fexofenadine with the acceptable intra- and intercycle accuracy, precision and stability. The method was tested on rabbits after the intravenous administration of fexofenadine at the dose of 11 mg/kg.

Conclusion. The HPLC methods of fexofenadine quantitative determination in the hepatic tissue of rabbits has been worked out. It can be used for the evaluation of the functional activity of Pgp in preclinical studies.

Abbreviations: Pgp – P-glycoprotein, HPLC – high performance liquid chromatography, rev/min – revolutions per minute
Betamethasone administration as a treatment of choice in local post-tattoo complications
Authors: Karymov O. N. , Vorobyov A. A. , Kalashnikova S. A. , Polyakova L. V. , Vyskub M. N.
Published: May 2020

The aimof the study is to determine the effectiveness of betamethasone in the treatment of local post-tattoo complications, depending on the mode of administration.

Materials and methods.The work was carried out on 90 male rats which had been tattooed (n = 30 – a negative control group; n = 30 – a comparison group: a subcutaneous administration of 1 ml of a betamethasone solution; n = 30 – an experimental group: an administration of 1 ml of a betamethasone solution using a tattoo machine), 15 – intact rats. Withdrawal from the experiment took place on the 3rd, 10 th and 21st days. The skin samples were fixed in 10% formalin, followed by histological posting and manufacturing of micropreparations, then staining with hematoxylin and eosin, according to Van Gieson. A morphometric study included determination of the volume fraction (VF) of the epidermis; dermal fibers; pigment; inflammatory cells; macrophages (%), as well as the pigment depth (μm) and the severity of edema.

Results.The study found out that in the process of the betamethasone administration using a tattoo machine, the drug was uniformly administrated over the entire area of the tattoo; hereby, the phenomena of edema and inflammatory infiltration were insignificant. The dermal fibers were located in each layer with no signs of edema and with single cells of inflammation, respectively. The data of the histological processing were completely consistent with the results of morphometry: it was found out that in the experimental group, edema significantly decreased, the volume fraction of the pigment and macrophages decreased, and the volume fraction of the dermal fibers increased. The estimation of the inflammatory reaction was carried out according to the morphometric parameters of the volume fraction of inflammatory cells and had significant differences in all the experimental groups, decreasing in the following series: the negative control group> the comparison group> the experimental group> the group of intact animals (p <0.05).

Conclusion.Based on the data obtained, the effectiveness of betamethasone in the treatment of local post-tattoo complications has been proved. In this case, the treatment of choice is the administration of this drug not traditionally subcutaneously, but using a tattoo machine that enables the targeted delivery of the substance to the area of the pathological process.

Abbreviations:NC – negative control, VF – volume fraction
Retrospective analysis of adverse drug reaction reporting forms associated with penicillin family antibiotics (pcne-drp 9.0) based on drug-related approach
Authors: Matveev A. V. , Krasheninnikov A. E. , Egorova E. A. , Koniaeva E. I.
Published: May 2020

A widespread use of β-lactam antibiotics such as penicillins in practical medicine, and its authorized use in special categories of patients (e.g. children, pregnant and lactating women, the elderly) requires a critical investigation of their safety as well as the obligatory risk assessment before conducting antibacterial pharmacotherapy.

The aim of the work was the conduction of a retrospective study of adverse reactions cases, the identification and analysis of drug-related problems (DRP) associated with the use of penicillin family antibiotics.

Materials and methods. The objects of the study were adverse drug reactions (ADR) associated with the use of penicillin family antibiotics in inpatient and outpatient facilities, as well as the cases of self-treatment, which were recorded in the official ADR reports and then inputted in the regional (Republic of Crimea) database of spontaneous reports called ARCADe (Adverse Reactions in Crimea, Autonomic Database). The covered period is 2009–2018. The analysis of DRP was carried out using the 9.0 version of the qualification system DRP PCNE (Pharmaceutical Care Network Europe Foundation).

Results. The data analysis of ADR reporting forms has revealed that Amoxicillin clavulanate and Amoxicillin were the most frequent cause of ADR. A high incidence of penicillins ADR in pediatric patients (from 0 to 18 years) – 142 cases – has been found. The clinical manifestations of reactions included drug hypersensitivity reactions (309 cases), dyspeptic disorders (28 cases) and disorders of the central nervous system (5 cases). The incidence of serious ADR was 113 cases (33% of the total number of ADR in the study), which indicates a rather high risk of developing severe ADR for penicillins, resulted in a significant decrease in the quality of patients’ lives.

Conclusion. The detection of DRP using the PCNE V9.0 approach is a useful and promising tool important to improve the quality of pharmacotherapy and their adherence to treatment. The highest DRP values which were observed for Amoxicillin clavulanate and Amoxicillin, may indicate a high frequency of irrational use of these drugs.

List of abbreviations: DRP – drug related problems; ADR – adverse drug reactions; INN – international non-patented name
Problems of pharmaceutical provision of population with hypolipidemic drugs: the case of the Volgograd region (the Russian Federation)
Authors: Tyurenkov I. N. , Knyazeva Yu. S. , Ganicheva L. M. , Kaysheva N. Sh.
Published: May 2020

The aim of the studyis to study the regional hypolipidemic drugs market, external and internal factors affecting their level of consumption, including the information awareness of the final customers about this pharmacotherapeutic group and the adherence to treatment with these drugs.

Materials and methods.The study was carried out using the methods of SWOT and STEP-analyses to assess the factors affecting the consumption of the studied group of drugs, as well as the questionnaire method of final customers and assessing their compliance using the Morisky-Green questionnaire.

Results.The influence of environmental and internal factors on the level and structure of the consumption of hypolipidemic drugs has been studied, hereby, the problems of the group and ways to solve them have been outlined, and an increase or decrease in the need for hypolipidemic drugs at the regional level, have been predicted. The assessment of the information awareness and preferences of the final customers of hypolipidemic drugs has been carried out, and insufficient awareness of patients about the drugs under study, has been revealed. The compliance of the final customers has been studied. A low level of the compliance of the patients to the prescribed hypolipidemic therapy has been established.

Conclusion.Modern advances in the treatment of cardiovascular diseases, based on fundamental achievements of science and practice, have created a high evidence base for the choice of strategies for pharmacotherapy with hypolipidemic drugs. The main ways to increase information awareness and compliance of the final customers are: development and intensification of educational programs to increase the level of knowledge and information awareness of doctors and pharmaceutical professionals, establishing theDoctor-Patientpartnering relationships, increasing the trust level to the doctor and, as a result, the level of the patient compliance уровень; the development of materials for increasing the information awareness among the final customers about hypolipidemic drugs and hypolipidemic therapy in general.
Representaciones sociales de empleo y desempleo de trabajadores de la salud de Bogotá, Colombia y de Morelia, México
Authors: Torres-López Teresa M. , Quezada-Valadez María Guadalupe , Herrera-Pérez Juana Imelda
Published: May 2020

Introducción: Los procesos intersubjetivos de los trabajadores de la salud en el marco de la cultura en que viven conforman las representaciones sociales (RS) sobre empleo y desempleo, las que permitirán acceder a su mundo de significados. Objetivo: Describir las RS de empleo y desempleo de trabajadores de la salud con el fin de comparar dos contextos Latinoamericanos Morelia, México y Bogotá, Colombia. Metodología: Se utilizó la técnica de listados de asociación libre a 84 participantes para conocer los temas y la organización de las RS, así como la descripción del núcleo central y los elementos periféricos. Resultados: Las RS empleo lo caracterizan como una actividad que genera una base económica a la vez que se obtiene bienestar, crecimiento personal que requiere de responsabilidad. Las principales diferencias son que en Bogotá se destaca a los compañeros y  la posibilidad crecimiento como una faceta positiva y como negativo la carga laboral, mientras que en Morelia se destaca la satisfacción que implica su realización y como un aspecto negativo el tiempo requerido. Las RS de desempleo son de un estado de inactividad que genera depresión e incertidumbre, además de problemas familiares y sociales. En las diferencias en Bogotá se cita la falta de dinero, la inestabilidad, la angustia y los problemas familiares; en Morelia su énfasis es en el ocio, la desocupación y sus efectos en la salud. Conclusiones: En las RS encontradas se identifican elementos que podrían relacionarse a la exposición a riesgos psicosociales y de condiciones precarias en el trabajo.
Palaeomagnetic and rock magnetic properties of loess-palaeosol sequences in Belgium
Authors: HUS Jef J. , GEERAERTS Raoul
Published: May 2020

Palaeomagnetic investigation of several sections in the loess cover of Belgium proves that they contain a stable remanent magnetization reflecting ancient field behaviour. Reversed magnetozones could not be detected so far indicating that the examined sections belong to the Brunhes Chron. Also short-term reversals seem not to be present and large directional deviations can be attributed to frost wedging, solifluction and other periglacial activities. In contrast with Central and Eastern Europe and Asia, soil magnetic enhancement is absent except for the humic soil horizon overlying the Rocourt soil. The strong magnetic properties in this horizon revealed in Tongrinne and Rocourt are mainly due to the presence of minerals of volcanic origin.
Quaternary palaeobotanical evolution of Northern Belgium
Authors: VERBRUGGEN Cyriel
Published: May 2020

The palaeobotanical data set of northern Belgium has to be divided into two parts: a post-glacial part including the Lateglacial and the Holocene period, and a Pleistocene part including the entire period between the beginning of the Quaternary and the end of the Weichselian glacial. A continuous and sufficiently documented record is present for the post-glacial period. As a standarised summary has been published recently (Verbruggen et al., 1996), this period is not discussed systematically. This paper focusses on the Pleistocene part of the data. The main problem about this data is the fact that most of it is unpublished. By incorporating the unpublished data and confronting them with the present-day theories from the neighbouring countries, it became possible to present an overview of the Pleistocene palaeobotany of northern Belgium. Interesting new data are added for the Saalian-, Eemian- and Early-Weichselian period.
A diatom and radiocarbon perspective of the palaeoenvironmental history and stratigraphy of Holocene deposits between Oostende and Nieuwpoort (Western Coastal Plain, Belgium)
Authors: DENYS Luc
Published: May 2020

Diatom and radiocarbon data of two cores from the north-eastern part of the western Belgian coastal plain are discussed. The palaeoenvironmental reconstruction of these sites and additional stratigraphic and geochronological information, allow an assessment of the general development of this region throughout the Holocene. Prior to c. 7500 yrs cal. BP a rapidly transgressing coast exists. Basal peat development may have been fairly widespread. Extensive erosion channels form towards the interior once the volume of the developing tidal basin has increased sufficiently. In spite of very high rates of sediment accumulation, high-intertidal environments remain poorly developed due to the high rate of RSL rise and the relatively steep slope of the transgressed terrain. Diatom taphocoenoses of this period consist primarily of coastal tychoplankton (mainly Cymatosira belgica), deposited in association with flood transported sediment, and some epipsammon. Hereafter, the incidence of negative tendencies in marine influence increases, culminating between c. 6300 to 5600 yrs cal. BP. Diatom assemblages are now more varied with an improved representation of tidal flat and salt marsh communities. The marine species Paralia sulcata and Pseudopodosira westii become abundant in high intertidal deposits, which may involve selective transport, sedimentation and preservation mechanisms. In general, the environmental changes reflect the development of a broad intertidal sedimentation zone in which sediment supply remained high, combined with a gradual slowing down of the RSL rise. Coastal progradation finally leads to sufficiently sheltered conditions for long-lasting peat growth in the intracoastal area up to perhaps c. 2100 yrs cal. BP. Presumably a coastal barrier, which remains intersected by some inlets, also develops during this period. At places, peat growth is interrupted at about 4200 yrs cal. BP by a marked but short-lived period of marine sedimentation. Within the general framework of a return to a transgressive setting and a destabilisation of the barrier system due to a decreasing sediment supply, climatic conditions and human interference may have played a role in the final termination of peat growth and the resumption of tidal activity. So far, the exact chronology of the return of tidal sedimentation in the study area remains unclear. No general sedimentation cycles, or so-called Dunkerque transgressions, are identified during the deposition of the upper tidal deposits, which are again characterized by a high representation of Cymatosira, reflecting a more open coastal setting. A tentative chronology of regional tendencies in the marine influence is derived from both bio- and lithostratigraphical indications and compared with the assumed chronology of transgressive and regressive phases in the northern Netherlands. Points of agreement are discussed in terms of possible supra-regional processes.
Literary blogs and podcasts as formats of book media events
Authors: Ageeva G. M.
Published: May 2020

Using the example of literary-specialized blogs the article shows the gradual virtualization of readers' practices, the changes in book perceptions in the media environment, and the overall mediatization of Russian book culture. The main problem raised in the article: how digital technologies transform book culture, what are the specifics of these changes, and is it possible to preserve the key meanings of the Russian book culture in the context of convergence of traditionalism with the new cultural reality. The purpose of the article is to consider literary blogs and podcasts as book media formats in the context of the global cultural agenda and changes in the field of Russian book consumption. The author treats different aspects of book's phygitalization and digitalization, its rootedness in the media space and the need for media support; compares popular online readers services and media projects on reading popularization. The main conclusions are: it is impossible to imagine modern readership outside the media and blogosphere, primarily due to their high communicative capabilities. Book services provide a virtual platform for discussing what is read, initiating a dialogue; blogs are one of most popular and effective tools for orientation in the literary process and the development of book communication; blogosphere changes the perspective of the perception of book culture, offers non-standard approaches to its understanding.
Information culture and media literacy in the structure of the library cultural and educational activities
Authors: Kavalerchik T. B.
Published: May 2020

Due to the active expansion of the media environment, convergent processes occurring in the modern socio-cultural space, there is a need to create information and educational platforms on forming information culture of population and, in particular, school-age children. The article describes the results of a study on creating favorable cultural and educational conditions for organizing systematic work on information culture and media literacy formation for children of middle and high school age in a library. The goal of the study is to build a universal model of the educational program with its subsequent implementation in the library environment. Its tasks were: 1) to make experiments on testing interactive lessons on the course «Information Culture in the Study of the Native Land Literature», developed according to the proposed universal model; 2) to analyze the results of experimental work; 3) to design the development program for the Information and Digital Culture Center of the Sakhalin Regional Universal Scientific Library for it to form information culture and media literacy for various population groups, in particular, the young generation. The article assesses the significance of the problem, describes the research parameters, and presents the results of testing the course "Information culture in the study of literature of the native land». The development program of the center for information and digital culture of the Sakhalin Regional Universal Scientific Library was made, designed to solve the problem of forming the information culture of the younger generation.
The Book Transformations in the Context of Media Revolutions
Authors: Lizunova I. V. , Pavlenko S. V.
Published: May 2020

The article is devoted to the analysis of book transformation as one of the oldest and the most influential types of media in the historical context of media revolutions. It characterizes the main attributes of media, underlining common features of the book and other types of media. The article explores the evolution and specific changes of oral, written and electronic information carriers and other types of media in the context of time and space. It analyses historical conditions and the modern tendency to reproduce a book in audio and electronic formats. The article also claims that such transformations make a significant impact on the classical relationship between all participants and stakeholders in book creation, production, distribution and usage. The authors emphasize the importance and further impact of large-scale changes in the nature of book in the context of media revolutions. The history of humankind has undergone four media revolutions. At present one can observe transforming the world and domestic book markets: new market segments are being formed and continue to develop. The most important trend is the transformation of the book as medium and the appearance of its new features and communication opportunities. The article considers the processes of mediatization that transform mental landmarks of contemporaries, and form new skills and techniques that are essential in modern communication. Mutual influence and modification of information channels and message itself, lead to the modification the perception of texts. All these processes require the development of new media authors’, text creators’, publishers’, editors’, readers/users’, media consumers’ competences, and ultimately change communication abilities and the priorities of all media consumers. The authors underline the necessity to create and use a new transdisciplinary medialogical approach to book research and its industry in space-time context.
Itinerary books (itineraria) of the Vysotskys’ printing house
Authors: Dvortsova N. P.
Published: May 2020

The study gives a new outlook on the activities of the first Tyumen printing house, which was founded by K. N. Vysotsky in 1869 and existed until 1909. The scientific novelty of the research is due to the following: 1) book publishing is considered as part of the media revolution carried out by K. N. Vysotsky thanks to the opening of the first photography studio (1866), lithography studio (1867), printing house (1869), and a newspaper publishing news and advertisements (1879) in a provincial Siberian town; 2) publishing activities of K. N. Vysotsky and L. K. Vysotskaya are linked with the history of Siberian steam navigation in the 1870–1890s. The purpose of the article is to characterize Russian dorozhniki - itinerary books as a special type of publications in the Vysotskys’ printing house, to identify their diversity and role in the activities of steamship companies, in particular the Kurbatov and Ignatov Partnership. A bibliological analysis based on the structural-typological method within the context and system approaches allows a new interpretation of the role and place of the Vysotskys’ printing house in the history of Siberian book culture. The author comes to the conclusions that about 20% of the repertoire (11 of 56 books) of the Vysotskys’ printing house are books about steamboats and rivers. They represent a semantic unity, a unique series structured by space (more than 3000 km along West Siberian rivers from Tyumen to Tomsk) and the idea of industrialization and cultural development of new lands. The structural dominance of the series belongs to a special publication type: dorozhnik (an itinerary book), the purpose of which was to indicate the distance between settlements and to serve as a travel guide on Siberian rivers. Publication of such books, which are known to exist since the ancient Rome, testifies to the high print culture of the Vysotskys publishers. These books are very diverse: brief guidebooks coexisted with lithographic cartographic editions and advertising catalogs in the genre of history writing and ethnographic travel essays. The significance of the itinerary books published by the Vysotskys lies in the cultural brand they formed for Tyumen as a town and the birthplace of all navigation along West Siberian rivers.
Publishing houses and publishing organizations in Siberia and the Far East as popularizers of the historical and cultural heritage of the region
Authors: Troyak I. S.
Published: May 2020

Due to the rapid globalization in the second half of the 20th century the problems of preserving and studying the historical and cultural heritage of certain territories of national states have become especially relevant and socially significant. Since the book is a form of presentation of cultural heritage values, the memorial function responsible for preserving the heritage of certain territories and making population familiar to it is of fundamental importance for regional book culture. The purpose of the study presented in the article is to reveal ways to implement the memorial function of the regional book culture in Siberia and the Far East in the 2000–2010s. As a methodological basis, the theoretical model of book culture proposed by K. Migoń was used, who distinguishes the local, regional, national, supranational, cultural-civilizational and world “cultural circles of the book”. The activities of publishing houses and publishing organizations in Siberia and the Far East are treated within the local and regional “circles” as a part of the national Russian book culture. The article shows the main actors of modern local history book publishing in Siberia and the Far East: these are the majority of regional publishing houses and those publishing organizations whose activities are institutionally related to the preservation of historical and cultural heritage (museums, archives and libraries). Methods for popularizing their products are presented. For the first time, examples of product placement in advertising local history literature are identified and presented. The author concludes that Internet is becoming the main channel for the dissemination and popularization of regional local history book production, that opens the access to a wider circle of readers of historical and cultural heritage of Siberia and the Far East.
Book public pages in Instagram
Authors: Rubanova T. D.
Published: May 2020

The peculiarity of the Russian-language Instagram segment is that for many users it has become the platform for text self-expression and discussions (including on reading issues). This explains the fact that many publishers and bookstores create their own Instagram accounts to promote book products. The purpose of the article is to identify the marketing potential of book public pages in Instagram. The author sets the following tasks: to identify successful practices of publishers and bookselling organizations in Instagram; analyze them from the point of view of text content, visual design; identify the main forms of users engagement; calculate the engagement rate (ER); identify possible "recipes" for the success of book public pages. Viewing the official websites of publishers and bookstores allowed the identification of book public posts with a significant number of subscribers and that of forms to attract users, and the determination of content features and visual design. A comparison of the activity level of public pages: @ eksmolive and @mifbooks of two major publishing houses. For this purpose, the number of posts, likes and comments for the period from 23.10.2019 to 22.11.2019 was calculated, as well as the engagement rate using the ER method. The author comes to the conclusion that the Instagram is widely used by publishing organizations and booksellers as a promising platform for book promotion and reading support, active exchange of information with the audience, increasing people’s loyalty, brand promotion, organization of direct sales. Effectiveness of the presence of booksellers in Instagram largely depends on the competent segmentation of the audience, the uniqueness of the content and visual design, and the use of various techniques and methods to enhance user engagement.
Communication and media usage of the older generation of Sakhalin repatriates in Japan
Authors: Sakuma S. L.
Published: May 2020

The aim of the article is to find out the features of communication and media usage among the older generation of Sakhalin repatriates in Japan. To achieve this aim we set up the following tasks: 1. To define what media and what language are used by the older generation of Sakhalin repatriates; 2. To make it clear what media are used by the older generation of Sakhalin repatriates for communication inside Japan and abroad; 3. To elucidate the changes and their reasons in media usage by the older generation of Sakhalin repatriates occurred since the beginning of their repatriation. This article is based on interviews with 9 respondents conducted between August and October in 2017. All respondents represent the older generation. The field study covered 5 cities (in alphabet order): Asahikawa, Hakodate, Sapporo, Tokyo, Wakkanai. The middle age of respondents is equal to 70 years and 3 months. Previous studies on Sakhalin repatriates in Japan were on the issues of the pre-repatriation period, cultural background, language level, identity factors, adaptation strategies different for each generation of Sakhalin repatriates. However, the issues connected with communication and media usage has never been the subject for a special study. The results of the study can be used for understanding the features of such a phenomena as repatriation, as well as the modern communication processes both in Japan and the world. The author comes to the following conclusions: 1. The older generation of Sakhalin repatriates is able to maintain a multicultural space of living by using multilingual media and conducting transnational communication; 2. There are differences in new media usage among the older generation of Sakhalin repatriates. These differences arise not only from lack of media literacy but also from social and economic status of repatriates and their needs.
Book in the media systeme
Authors: Vokhrysheva M. G.
Published: May 2020

Book functioning in the modern society, called by the researchers not only as an information but also a media one, has changed. Book and media are considered as unique phenomena the essence of which being reflected in sense-filled notions. The aim of the article is to reveal the place of book in the media space. Its tasks are: 1) on the base of modern home and foreign dictionaries and encyclopedias to show the difference in approaches to definitions and expose the content of the concepts “book” and “media”; 2) to demonstrate the specifics of the book entering into contemporary media sphere both on the level of its transformation into new existence forms in the electronic environment and on the level of its being as an independent unit in the form of a printed book; 3) to establish the possible methodological approaches to the investigation of the problem and suggest the methodology of transdisciplinarity as the basic one. Methods used are: theoretical analysis and generalization, terminological analysis, transdisciplinary approach. The term “media” describes the whole sphere of activity (“media sphere”) in the centre of which are means of information and communication, social institutes, dealing with the content production and delivering it to the public. The book is included into this sphere transforming its form into a new electronic one and getting benefits through the variability ofelectronic resources, virtuality, a new language and communicative formats. A printed book with its great number of valuable properties, first of all ability to influence inner cognitive and psychological perception structures while reading faces significant difficulties in its publishing and dissemination; it’s transferred into the second row of information policy and mass cognition. Thus, it’s methodologically important to consider book in any form as a significant element in the modern media sphere. It’s promising to use the transdisciplinary approach to book research when it is studied not by aspects from the viewpoint of this or that discipline but as a whole using all acquired knowledge.
Audiobook, audio podcast, audio series – modern formats of the media space
Authors: Bal V. Yu.
Published: May 2020

The article discusses modern audioformats – audiobook, audio series and audio podcast. Now these formats have gained great popularity and demand, considerable market weight with their own segment, the growth of which experts note. The research material is audio products of the modern market, which reflect the trends in the development of audio literature in the current media environment. The scientific novelty of the work consists in the consideration of an audiobook, an audio series and an audio podcast in the context of a new stage in the development of audio culture. The problem of popularity of the studied audio products is considered in direct dependence on audio reading. It is understood as a modern modification of auditory reading, as a reader’s practice due to the qualitative changes in the material and technical base for creating audio records, for their copying and use. The analysis of audio formats in the informational, sociocultural and cognitive aspect of the modern media consumption allows the determination new editorial approaches to the work with audio texts. Conclusions are as follows: one can observe the tendency to transit from voicing printed texts to creating texts specially for voicing; there is a reduction in the novel form, stories become popular; the editing of audio books and audio series requires support from sound design principles; the editorial and director’s task on preparing podcasts is associated with the compositional alignment of several voices of storytellers, forming a single ideological and thematic field.
Modern library and reading in multimedia environment
Authors: Askarova V. Ya.
Published: May 2020

The article identifies the library's ability to stimulate reader activity in the context of the multimedia culture development. It also considers main changes in the library activities as an organizer of reading in multimedia culture including the increase of emphasis on readers, their subjectivity, interaction dialogue forms development, multimedia projects implementation, online services and digital resources introduction, education of readers on literate media behavior and text activity in the Internet. The author states that in the context of multimedia, library can become an active participant in overcoming information chaos, streamlining information flows, enhancing reading and also contribute to the development of inter-reader communication. The article concludes that it is necessary to prepare library specialists, tutors, ready to organize communication about books and reading in a real and virtual environment, network navigation, analysis of Internet resources, recognition of misinformation, and teaching readers various techniques of textual activity.
E-books market in Poland. A Few good men’s passion in a non-reading society
Authors: Chmielewska В.
Published: May 2020

The article’s aim is to give an overview of the e-books market in Poland, including some issues from the history and perspectives of its future development; to reveal the role of authors and bloggers in popularizing e-books and e-reading; to elucidate how preferences of Poles in e-books reading devices and their attitude towards electronic reading were changing; to analyse problems that publishers and e-books sellers face. The article is based on social interrogation data, works of researchers and Polish book market analysts. The period between 2009–2018 demonstrate the following main characteristics of the market: rapid changes in technology, necessary for creating e-books; changing habits of the Polish readers, the lack of systematized approach to e-books as new media and economic barriers such as rather high VAT rate for digital publications. The paper underlines also the role of individuals and their initiatives in shaping the broadband culture. The basic conclusion of the work is as follows: Polish e-books market is still at the stage of forming its main segments. This work novelty and theoretical significance is in exposing and characterizing tendencies of e-books market evolution in Poland. Practical significance of the work is in acknowledging the necessity of attracting publishers, librarians and researchers to solving problems of creation in the country a constantly renovated database of electronic editions, its accessibility by Pole users.
The Capabilities of Amlodipine/Lisinopril Single-Pill Combination in the Treatment of Newly Diagnosed Arterial Hypertension in a Middle-Aged Patient (Case Report)
Authors: Kochetkov A. I. , Lopukhina M. V. , Kotaeva E. A. , Kirichenko A. A. , Ostroumova O. D.
Published: May 2020

Arterial hypertension (AH) is one of the most significant modifiable risk factors that increase cardiovascular morbidity and mortality worldwide, including Russia. The complex of structural and functional changes in the heart that occurs during AH consists not only in the formation of left ventricular (LV) myocardial hypertrophy, but also in the myocardial stiffness increasing due to collagen formation and cardiomyocytes apoptosis. These abnormalities are substrate for diastolic function disturbances, electrical myocardial instability and ischemia. The article provides a clinical case of amlodipine/lisinopril single-pill combination (A/L SPC) use in real clinical practice in a patient with stage II grade 2 newly diagnosed AH and its effect on blood pressure and echocardiographic myocardial fibrosis markers, including speckle tracking parameters The high antihypertensive efficacy of A/L SPC, a favorable effect on blood pressure circadian rhythm, as well as pronounced target-organ protective properties, in particular the ability to reduce LV and left atrial stiffness, were demonstrated. So, we conclude that A/L SPC improve the elastic properties of the left heart.
Soluble Guanylate Cyclase Stimulators for Chronic Thromboembolic Pulmonary Hypertension Patients Treatment: New Data
Authors: Simakova M. A. , Moiseeva O. M.
Published: May 2020

This narrative review describes and appraises some relatively new studies investigating the efficacy and safety profile of soluble guanylate cyclase stimulator riociguat in patients suffering from pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). It has been a while since the publication date of pivotal CHEST-1 trial in 2013. New studies available complement existing evidence, expound on specific questions and open new frontiers for CTEPH investigations going forward. In this paper authors attempted to present data from post-hocanalysis of the CHEST-1 study and real-world data on riociguat treatment, confirming the positive effect of the drug on hemodynamic parameters of the pulmonary circulation and the functional status of patients. This effect was shown previously in large randomized trials. The extremely important positive effect of riociguat demonstrated both in the group of inoperable patients with CTEPH and in patients with residual pulmonary hypertension after pulmonary thrombendarterectomy. Of great interest are the presented some authors results of reverse remodelling of the right heart chambers during riociguat therapy in CTEPH patients, including using unique imaging methods (magnetic resonance imaging and positron emission tomography) to evaluate targeted medicinal therapy in terms of right heart remodelling. The safety profile of the drug was analyzed in the long-term post-registration international, multicenter, prospective, observational study EXPERT (NCT02092818), which confirmed the good tolerability and safety of riociguat therapy in PAH and CTEPH patients.
Off-Label Medicines Use: Complex Problem of Modern Clinical Practice
Authors: Gilyarevskiy S. R.
Published: May 2020

World experience in off-label medicines use is presented in the article. Data on the history of changes in tactics and approaches to solve the problem of medicines off-label use in the USA and some European countries, as well as in the European Union as a whole, are presented. The reasons, why doctors should use medicines off-label, are discussed. The expert opinion on the conditions ensuring the maximum safety in off-label medicines use is presented. In particular, the validity of obtaining patient informed consent is discussed. The article does not apply to the Russian regulation regarding “off-label” therapy but describes the foreign practice related to off-label medicines use. In addition, the results of some recently completed randomized clinical trials evaluating the effects of direct oral anticoagulants are presented in order to demonstrate the need to clarify the effectiveness and safety of medicines used in certain clinical situations. The results of such studies clarify the indications for the drug use, which are subsequently entered into the summary of product characteristics.
ASAS LEGALITAS DALAM DOKTRIN HUKUM INDONESIA: PRINSIP DAN PENERAPAN
Authors: Timoera Dwi Afrimeti
Published: May 2020

The principle of legality is a principle which determines that no act which is prohibited and punishable by criminal if not determined in advance in legislation. This principle is usually known as nullum delictum nulla poena sine praevia lege (no offense, no crime without law first. There are four principles of legality that is, the lex scripta (written law), lex chert (which includes criminal law), nonretroaktif (rule not retroactive) and analogy.
PERISTIWA CHINESETROUBELEN DI BATAVIA
Authors: Fuad Fokky
Published: May 2020

This study aimed to describe the genocide descriptively Chinese in Batavia that occurred in October 1740. Event known as Chinatown Chinese troubelen or commotion, is the first step of ethnic segregation in Indonesia are carried out systematically by the Trade Union of the East Indies Company (VOC). Ethnic Chinese were targeted over policy administration errors VOC in Batavia, where they need to create a tangible goal that can be used as a scapegoat of the various errors. Thus, VOCs can avoid accusations of failure of the administration
WACANA AMANDEMEN KELIMA UNDANG-UNDANG DASAR 1945 SEBAGAI LANGKAH MEWUJUDKAN ARSITEKTUR KONSTITUSI DEMOKRATIK
Authors: Maiwan Mohammad
Published: May 2020

The amendment of constitution is something commonly done and is part of the practice of national life. In Indonesian society there is some perspectives of the fifth constitution amendment. The first, is a group that wants the fourt constitution amendment retained. Secondly, a group that wants the amendment of the constitution. Third, is the group that want to go back to the original 1945 constitution. However, the amendment must be conducted in-depth, thorough, consistent, integrated, thus strengthening the Indonesian constitutional system. The main aspect that should be emphasized is to restore sovereignty to the people through the implementation of participatory democracy and good governance.