bluuebunny/crossref_metadata_2025 huggingface dataset:
A Multiplier-less Implementation of Two-Dimensional Circular-Support Wavelet Transform on FPGA
Authors: Abdul-Jabbar Jassim , Abede Zahraa , Dawood Akram
Published: April 2020

In this paper, a two-dimensional (2-D) circular-support wavelet transform (2-D CSWT) is presented. 2-D CSWT is a new geometrical image transform, which can efficiently represent images using 2-D circular spectral split schemes (circularlydecomposed frequency subspaces). 2-D all-pass functions and lattice structure are used to produce 1-level circular symmetric 2-D discrete wavelet transform with approximate linear phase 2-D filters. The classical one-dimensional (1-D) analysis Haar filter bank branches H0(z) and H1(z) which work as low-pass and high-pass filters, respectively are transformed into their 2-D counterparts H0(z1,z2) and H1(z1,z2) by applying a circular-support version of the digital spectral transformation (DST). The designed 2-D wavelet filter bank is realized in a separable architecture. The proposed architecture is simulated using Matlab program to measure the deflection ratio (DR) of the high frequency coefficient to evaluate its performance and compare it with the performance of the classical 2-D wavelet architecture. The correlation factor between the input and reconstructed images is also calculated for both architectures. The FPGA (Spartan-3E) Kit is used to implement the resulting architecture in a multiplier-less manner and to calculate the die area and the critical path or maximum frequency of operation. The achieved multiplier-less implementation takes a very small area from FPGA Kit (the die area in 3-level wavelet decomposition takes 300 slices with 7% occupation ratio only at a maximum frequency of 198.447 MHz).
PENINGKATAN MOTIVASI DAN KEMAMPUAN BERPIKIR KRITIS MAHASISWA MELALUI MODEL PEMBELAJARAN BERBASIS MASALAH BERBANTUAN MEDIA EDMODO
Authors: Suparya I Ketut
Published: April 2020

Tujuan penelitian ini adalah 1) untuk mendeskripsikan peningkatan motivasi mahasiswa melalui model pembelajaran berbasis masalah berbantuan media edmodo, 2) untuk mendeskripsikan peningkatan kemampuan berpikir kritis mahasiswa melalui model pembelajaran berbasis masalah berbantuan media edomodo, 3) untuk mendeskripsikan respon mahasiswa terkait penerapan model pembelajaran berbasis masalah berbantuan media edomodo. Penelitian ini merupakan penelitian tindakan kelas dengan subyek penelitian ini seluruh mahasiswa semester IV program studi Pendidikan Guru Sekolah Dasar STAH Negeri Mpu Kuturan Singaraja sebanyak 20 orang mahasiswa. Obyek penelitian adalah motivasi belajar mahasiswa dan kemampuan berpikir kritis pada pembelajaran IPA SD. Metode analisis dalam penelitian ini adalah deskriptif kualitatif.  Adapun hasil dari penelitian ini adalah sebagai berikut: 1) terjadi peningkatkan motivasi belajar mahasiswa dari 66,27% pada siklus I menjadi 82,25% pada siklus II, atau peningkatan sebesar 15,98% berada pada kategori baik, 2) terjadi peningkatan kemampuan berpikir kritis mahasiswa dari 69,50%  pada siklus I menjadi 84,40% pada sisklus II atau peningkatan sebesar 15% berada pada kategori baik, 3) persentase rerata respon mahasiswa terhadap proses pembelajaran sebesar 80,10% berada pada kategori baik.
Predicting EdD Applicant Potential Using Structured Behavioral Interviews During the Application Process
Authors: Kimbrel Laurie A. , Varga Mary Alice
Published: April 2020

This essay describes the work of faculty at a public university in the southeast to align their application process with CPED principles through the addition of structured behavioral interviews. Their work was grounded in the premise that redefinition of the Ed. D. program to focus on the effective preparation of scholarly practitioners also requires a redefinition of the type of student who is most likely to benefit and, consequently, how the applicants most likely to achieve success are identified and admitted. A structured interview was added to the application process as a tool to gather data to accurately predict the likelihood of student success in the program and as a leader of change in schools. The development of the interview was guided by selection science literature, and questions were aligned to essential student attributes. Although the interview questions and process are still evolving, data from the initial administration suggests that the interview has promise as a useful element of the candidate selection process.
La creación del mundo on the Seventeenth-century Street and Stage
Authors: Thacker Jonathan
Published: April 2020

By 1629 there were two comedias entitled La creación del mundo in the repertoires of Golden Age acting troupes, one by Lope de Vega and the other by Luis Vélez de Guevara. From the texts of the plays, one a printed edition and the other a manuscript, and perhaps especially from the stage directions included in these playtexts, it is possible to make some tentative deductions about how and where these works—dramatizing the early chapters of the Old Testament Book of Genesis—were performed. Analysis of archival documentation from Badajoz together with these two playtexts and an awareness of performance norms of the period may help solve the riddle of which Creación came first, Lope’s or Vélez’s.
Las Kellys y el turismo: de la invisibilidad del cuidado a la visibilidad política
Authors: López-González José Luis , Medina-Vicent María
Published: April 2020

El trabajo desarrollado por las kellys o camareras de piso se caracteriza por encontrarse dentro de lo que se podría denominar como «trabajo de cuidados», aunque se inscribe de lleno en el campo productivo y es una parte vital del sector turístico. Su caso es un claro ejemplo de la intersección entre la precariedad y la invisibilidad de unas tareas que han sido histórica y culturalmente asignadas a las mujeres y condenadas al menosprecio social. En un contexto como el actual, cabe preguntarse sobre las condiciones sociales que subyacen a este colectivo y las implicaciones que se derivan de su situación de invisibilidad en un sector tan precario como el turístico dentro del Estado español, así como sobre el papel de Las Kellys –como asociación– en la reivindicación de los derechos laborales de las trabajadoras. Analizaremos su caso como una muestra de movimiento político y social que lucha por la visibilización de las tareas de cuidados y que contribuye a la repolitización de dichos trabajos en el ámbito público.
Demoscene: Arte en Tiempo Real
Authors: David Domingo Alegre David Domingo Alegre
Published: April 2020

David Domingo Alegre, profesor de la facultad de Informática de la Universitat Politècnica de Catalunya (UPC) nos habla en este artículo de su mayor pasión: la Demoscene, una disciplina underground del arte digital con mucha historia a sus espaldas.
O ENSINO DO SISTEMA ENDÓCRINO PELA PERSPECTIVA DA APRENDIZAGEM BASEADA EM PROBLEMAS / EDUCATION OF THE ENDOCRINE SYSTEM FROM A PROBLEM-BASED LEARNING PERSPECTIVE
Authors: De Souza Clauberto Medeiros , Rebeca Rosilene
Published: April 2020

Esta pesquisa  apoiou-se na Aprendizagem Baseada em Problemas (ABP) para ensinar a fisiologia do sistema endócrino humano e mediar a aprendizagem significativa. O objetivo primário foi possibilitar o protagonismo do aluno na construção de novos conhecimentos acerca da fisiologia do sistema endócrino por meio de uma sequência didática (SD) que continha um estudo de caso, além de discussões e reflexões intra e intergrupos.  Trata-se de uma pesquisa com abordagem qualitativa, de natureza aplicada e interpretativa, abrangendo os acadêmicos do 2º período do Curso de Fisioterapia da Faculdade Guairacá-PR. O diagnóstico dos saberes prévios e a evolução conceitual foram obtidos por meio de questionários semi-estruturados (pré e pós-teste). A comparação do pré e pós-teste demonstrou que os alunos agregaram novos significados aos já existentes e que aqueles que alegavam desconhecimento sobre o tema demonstraram evolução em suas concepções sobre os conceitos chave para a compreensão do tema.
A UTILIZAÇÃO DE CARTÕES TELEFÔNICOS NO ENSINO DE CIÊNCIAS: PROPOSTA DE UMA ATIVIDADE DIDÁTICA / THE USE OF TELEPHONE CARDS IN SCIENCE TEACHING: PROPOSAL OF A DIDACTIC ACTIVITY
Authors: Brandão Lucas De Esquivel Dias , Barros Marcelo Diniz Monteiro de
Published: April 2020

Uma pesquisa investigativa foi realizada na homepage: https://colnect.com/en/phonecards para contabilizar as imagens de mamíferos presentes nos cartões telefônicos existentes nos Estados Brasileiros que compõem a região sudeste do Brasil. Um total de 76 cartões telefônicos de diferentes operadoras de telefonia e de diferentes anos foi encontrado, sendo que 26 deles continham a imagem de mamíferos. Objetivando utilizar esses dados no Ensino de Biologia, uma atividade contendo 10 questões foi elaborada, para alunos do Ensino Médio, abordando aspectos fisiológicos, morfológicos, comportamentais, ecológicos e alimentares. Espera-se que os professores de Biologia tenham acesso a essa atividade e que possam discutir com seus alunos algumas das características biológicas existentes nos mamíferos aqui apresentados.
AS CONTRIBUIÇÕES DE DAVID AUSUBEL PARA OS PROCESSOS DE ENSINO E DE APRENDIZAGEM / DAVID AUSUBEL'S CONTRIBUTIONS TO THE TEACHING AND LEARNING PROCESSES
Authors: Scott Puhl Cassiano , Jacintho Müller Thaísa , Gianni de Lima Isolda
Published: April 2020

Este ensaio teórico descreve princípios da Teoria da Aprendizagem Significativa, com a intenção de auxiliar professores no planejamento de estratégias didáticas que promovam o protagonismo no estudante. O objetivo é identificar princípios da TAS que qualifiquem os processos de ensino e de aprendizagem na área da Educação em Ciências da Natureza e Matemática. Os pressupostos teóricos são oriundos das pesquisas de Ausubel, Novak e Moreira. Este estudo considera que o professor e o estudante possuem papel fundamental: o primeiro planejando materiais potencialmente significativos; e o segundo, ao realizar um esforço cognitivo para construir significados. Nesse sentido, a TAS possui potencial para qualificar a Educação em Ciências da Natureza e Matemática, pois entende o conhecimento prévio como o principal fator que influencia na aprendizagem; que a aprendizagem é um processo único para cada estudante; e que o nível de compreensão de um conhecimento depende da predisposição do estudante em aprender.
H2‐Directing Strategy on In Situ Synthesis of Co‐MoS2 with Highly Expanded Interlayer for Elegant HER Activity and its Mechanism
Authors: Jin Qiu , Liu Ning , Dai Chengna , Xu Ruinian , Wu Bin , Yu Gangqiang , Chen Biaohua , Du Yanze
Published: April 2020

MoS2 has drawn great attention as a promising Pt‐substituting catalyst for the hydrogen evolution reaction (HER). This work utilizes H2 as the structure directing agent (SDA) to in situ synthesize a range of Co‐MoS2‐n (n = 0, 0.5, 1.0, 1.4, 2.0) with expanded interlayer spacings (d = 9.2 – 11.1 Å), which significantly boost their HER activities. The Co‐MoS2‐1.4 with an interlayer spacing of 10.3 Å presents an extremely low overpotential of 56 mV (at 10 mA cm−2) and a Tafel slope of 32 mV dec−1, which is superior than most reported MoS2‐based catalysts. Density function theory calculations are used to gain insights that i) the H2 can be dissociatively adsorbed on MoS2 and greatly affect the related surface free energy by regulating the interlayer spacing; ii) the expanded interlayer spacing can significantly decrease the absolute value of ΔGH, thereby leading to greatly promoted HER activity. Additionally, the large amounts of 1T phase (73.9–79.2%) and Co‐Mo‐S active sites (40.9–91.3%) also contribute to the enhanced HER activity of the synthesized samples. Overall, a simple new strategy for in situ synthesis of Co‐MoS2 with an expanded interlayer spacing is proposed, which sheds light on other 2D energy material designs.
An Efficient Ultra‐Flexible Photo‐Charging System Integrating Organic Photovoltaics and Supercapacitors
Authors: Liu Ruiyuan , Takakuwa Masahito , Li Ailong , Inoue Daishi , Hashizume Daisuke , Yu Kilho , Umezu Shinjiro , Fukuda Kenjiro , Someya Takao
Published: April 2020

Flexible and biocompatible integrated photo‐charging devices consisting of photovoltaic cells and energy storage units can provide an independent power supply for next‐generation wearable electronics or biomedical devices. However, current flexible integrated devices exhibit low total energy conversion and storage efficiency and large device thickness, hindering their applicability towards efficient and stable self‐powered systems. Here, a highly efficient and ultra‐thin photo‐charging device with a total efficiency approaching 6% and a thickness below 50 µm is reported, prepared by integrating 3‐µm‐thick organic photovoltaics on 40 µm‐thick carbon nanotube/polymer‐based supercapacitors. This flexible photo‐charging capacitor delivers much higher performance compared with previous reports by tuning the electrochemical properties of the composite electrodes, which reduce the device thickness to 1/8 while improving the total efficiency by 15%. The devices also exhibit a superior operational stability (over 96% efficiency retention after 100 charge/discharge cycles for one week) and mechanical robustness (94.66% efficiency retention after 5000 times bending at a radius of around 2 mm), providing a high‐power and long‐term operational energy source for flexible and wearable electronics.
Presence phenomena in parkinsonian disorders: Phenomenology and neuropsychological correlates
Authors: Reckner Erin , Cipolotti Lisa , Foley Jennifer A.
Published: April 2020

Introduction

The feeling of a presence that occurs in the absence of objectively identifiable stimuli is common in parkinsonian disorders. Although previously considered benign and insignificant, recent evidence suggests that presence phenomena may act as the gateway to more severe hallucinations and dementia. Despite this, we still know relatively little about these phenomena.

Objective

To examine parkinsonian disorder patients' subjective experience of presence phenomena, and retrospectively analyse their cognitive correlates, in order to elucidate the emergence of information processing deficits in parkinsonian disorders.

Methods/Design

25 patients who endorsed presence phenomena were asked to complete a semi‐structured interview about their experiences. The cognitive profiles of these patients were then compared to those of age‐ and education‐matched patients who denied presence phenomena.

Results

Patients described the presence as mostly that of an unknown human with neutral valence. Patients who described it as unpleasant were noted to also demonstrate elevated anxiety. Patients who identified the presence as a known person, described it as touching them, or interacted with the presence emotionally or physically demonstrated reduced insight. Patients with presence phenomena demonstrated more frequent impairments in visual processing, executive function and speed of processing.

Conclusions

Presence phenomena occur in the company of advancing cognitive impairment and involvement of the posterior cortical functions. Initially encountered as a neutral spatial skeleton, the experience is then shaped by the patient's affective state and level of insight.
Surface disinfection practice in a hospital pharmacy aseptic compounding unit
Authors: Smith Evonne K.
Published: April 2020

Background

Hospital pharmacies that offer an aseptic medicine compounding service must ensure the final product is free from microbial, particulate and pyrogen contamination. Disinfecting medicines, consumables and containers prior to entry into the cleanroom environment is an essential step in minimising microbial contamination.

Aim

This study investigated whether spraying items with sterile ethanol 70% then wiping with 70% isopropyl alcohol‐impregnated wipes successfully disinfects items prior to transfer into the cleanroom.

Methods

Each compounding operator performed a left‐ and right‐hand finger dab sample after each compounding session for 2 months prior to and 2 months after implementation of the spray‐and‐wipe disinfection practice.

Results

Prior to the new disinfection practice, 96 finger dab pairs of samples were collected. No contamination occurred in 36.5% of sample pairs. Of the samples that were positive, 75% had three or fewer colonies per agar plate. After introduction of the spray‐and‐wipe practice, 84 finger dab pairs were collected. No contamination occurred in 82.1% of sample pairs and of the positive samples 93% had three or fewer colonies.

Conclusion

This study demonstrates that the disinfection practice of spraying items with sterile ethanol 70% and then wiping with 70% isopropyl alcohol‐impregnated wipes significantly reduces the rate of operator glove contamination, but does not fully eliminate contamination. These results must be considered along with other environmental monitoring results as part of the quality assurance process to minimise the risk of microbial contamination in the final product.
H+/K+ATPase Expression in the Larynx of Laryngopharyngeal Reflux and Laryngeal Cancer Patients
Authors: McCormick Caroline A. , Samuels Tina L. , Battle Michele A. , Frolkis Talia , Blumin Joel H. , Bock Jonathan M. , Wells Clive , Yan Ke , Altman Kenneth W. , Johnston Nikki
Published: April 2020

Objectives

The gastric H+/K+ ATPase proton pump has previously been shown to be expressed in the human larynx, however its contribution to laryngopharyngeal reflux (LPR) signs, symptoms and associated diseases such as laryngeal cancer is unknown. Proton pump expression in the larynx of patients with LPR and laryngeal cancer was investigated herein. A human hypopharyngeal cell line expressing the proton pump was generated to investigate its effects.

Study Design

In‐vitro translational.

Methods

Laryngeal biopsies were obtained from three LPR and eight LSCC patients. ATP4A, ATP4B and HRPT1 were assayed via qPCR. Human hypopharyngeal FaDu cell lines stably expressing proton pump were created using lentiviral transduction and examined via transmission electron microscopy and qPCR for genes associated with inflammation or laryngeal cancer.

Results

Expression of ATP4A and ATP4B was detected in 3/3 LPR, 4/8 LSCC‐tumor and 3/8 LSCC‐adjacent specimens. Expression of ATP4A and ATP4B in FaDu elicited mitochondrial damage and expression of IL1B, PTGS2, and TNFA (P < .0001); expression of ATP4B alone did not.

Conclusions

Gastric proton pump subunits are expressed in the larynx of LPR and LSCC patients. Mitochondrial damage and changes in gene expression observed in cells expressing the full proton pump, absent in those expressing a single subunit, suggest that acid secretion by functional proton pumps expressed in upper airway mucosa may elicit local cell and molecular changes associated with inflammation and cancer.

Level of Evidence

NA Laryngoscope, 131:130–135, 2021
Investigation on the Copolymer Electrolyte of Poly(1,3‐dioxolane‐co‐formaldehyde)
Authors: Liu Fengquan , Li Ting , Yang Yujie , Yan Jun , Li Ning , Xue Jinxin , Huo Hong , Zhou Jianjun , Li Lin
Published: April 2020

A series of copolymers are prepared via cationic ring‐opening polymerization with 1,3‐dioxolane (DOL) and trioxymethylene (TOM) as monomers. The crystallization behaviors of the copolymers can be suppressed by adjusting the ratio of DOL/TOM. With LiBF4 as a source for a BF3 initiator, copolymer electrolytes (CPEs) can be prepared in situ inside cells without needing nonelectrolyte catalysts or initiators. The ionic conductivities and Li+ diffusion coefficients () of the CPEs increase with a decreasing DOL/TOM ratio in a certain range. The CPE with a DOL/TOM ratio of 8/2 has the highest ionic conductivity as well as and shows excellent interfacial compatibility with lithium (Li) metal anodes. Li–Li symmetric cells can be uniformly plated/stripped for more than 1200 h. Furthermore, LiFePO4–Li cells with 8/2‐CPE display stable cycling performance for over 400 cycles. This strategy is a promising approach for the preparation of high‐performance polymer electrolytes and is sure to promote their application in Li metal batteries.
Abnormal Neural Responses During Reflexive Blinking in Blepharospasm: An Event‐Related Functional MRI Study
Authors: Nguyen Phuong , Kelly Diane , Glickman Amanda , Argaw Salem , Shelton Erika , Peterson David A. , Berman Brian D.
Published: April 2020

Background

The neurophysiological disruptions underlying blepharospasm, a disabling movement disorder characterized by increased blinking and involuntary muscle spasms of the eyelid, remain poorly understood.

Objective

To investigate the neural substrates underlying reflexive blinking in blepharospasm patients compared to healthy controls using simultaneous functional MRI and surface electromyography.

Methods

Fifteen blepharospasm patients and 15 healthy controls were recruited. Randomly timed air puffs to the left eye were used to induce reflexive eye blinks during two 8‐minute functional MRI scans. Continuous surface electromyography and video recordings were used to monitor blink responses. Imaging data were analyzed using an event‐related design.

Results

Fourteen blepharospasm patients (10 female; 61.6 ± 8.0 years) and 15 controls (11 female; 60.9 ± 5.5 years) were included in the final analysis. Reflexive eye blinks in controls were associated with activation of the right hippocampus and in patients with activation of the left caudate nucleus. Reflexive blinks in blepharospasm patients showed increased activation in the right postcentral gyrus and precuneus, left precentral gyrus, and left occipital cortex compared to controls. Dystonia severity negatively correlated with activity in the left occipital cortex, and disease duration negatively correlated with reflexive‐blink activity in the cerebellum.

Conclusions

Reflexive blinking in blepharospasm is associated with increased activation in the caudate nucleus and sensorimotor cortices, suggesting a loss of inhibition within the sensorimotor corticobasal ganglia network. The association between decreasing neural response during reflexive blinking in the cerebellum with disease duration suggests an adaptive role. © 2020 International Parkinson and Movement Disorder Society
Regularity criteria for a Ginzburg‐Landau‐Navier‐Stokes in superfluidity in Rn
Authors: Fan Jishan , Fukumoto Yasuhide , Zhou Yong
Published: April 2020

In this work, we prove some regularity criteria for a Ginzburg‐Landau‐Navier‐Stokes in superfluidity in
.
Practical consensus tracking control of multiple nonholonomic wheeled mobile robots in polar coordinates
Authors: Liu Lixia , Guo Rongwei , Ji Jinchen , Miao Zhonghua , Zhou Jin
Published: April 2020

This paper proposes a sliding‐mode control (SMC) method to achieve practical cooperative consensus tracking for a network of multiple nonholonomic wheeled mobile robots (MNWMRs) with input disturbances. A novel SMC surface under the nonholonomic constraints is first formulated to characterize the network communication interactions among the networked robots under the framework of polar coordinates. A unified distributed consensus tracking strategy is then proposed by systematically combining a position controller and a direction controller. Furthermore, a simple yet general criterion is derived to achieve the desired practical consensus of trajectory tracking and posture stabilization for MNWMRs. In particular, for a specific common consensus trajectory, the complete asymptotic tracking in heading direction can be fully guaranteed when the perfect asymptotic position‐tracking errors are realized. Accordingly, the developed consensus tracking strategy for MNWMRs demonstrates some advantages of control performance including stability, robustness, and effectiveness over the existing control method proposed for their single‐robot counterparts. Some comparative simulation results are given to confirm the effectiveness of the proposed cooperative consensus control method.
Plant viral nanoparticles for packaging and in vivo delivery of bioactive cargos
Authors: Shahgolzari Mehdi , Pazhouhandeh Maghsoud , Milani Morteza , Yari Khosroushahi Ahmad , Fiering Steven
Published: April 2020

Nanoparticles have unique capabilities and considerable promise for many different biological uses. One capability is delivering bioactive cargos to specific cells, tissues, or organisms. Depending on the task, there are multiple variables to consider including nanoparticle selection, targeting strategies, and incorporating cargo so it can be delivered in a biologically active form. One nanoparticle option, genetically controlled plant viral nanoparticles (PVNPs), is highly uniform within a given virus but quite variable between viruses with a broad range of useful properties. PVNPs are flexible and versatile tools for incorporating and delivering a wide range of small or large molecule cargos. Furthermore, PVNPs can be modified to create nanostructures that can solve problems in medical, environmental, and basic research. This review discusses the currently available techniques for delivering bioactive cargos with PVNPs and potential cargos that can be delivered with these strategies.

This article is categorized under:

Implantable Materials and Surgical Technologies > Nanomaterials and Implants

Biology‐Inspired Nanomaterials > Protein and Virus‐Based Structures
External validation of a prognostic model based on total tumor load of sentinel lymph node for early breast cancer patients
Authors: Piñero-Madrona Antonio , Ripoll-Orts Francisco , Sánchez-Méndez José Ignacio , Chaves-Benito Asunción , Gómez-de la Bárcena Maximiliano Rodrigo , Calatrava-Fons Ana , Menjón-Beltrán Salomón , Peg-Cámara Vicente
Published: April 2020

Background

A prognostic model based on the results of molecular analysis of sentinel lymph nodes (SLN) is needed to replace the information that staging the entire axilla provided. The aim of the study is to conduct an external validation of a previously developed model for the prediction of 5-year DFS in a group of breast cancer patients that had undergone SLN biopsy assessed by the One Step Nucleic Acid Amplification (OSNA) method.

Methods

We collected retrospective data of 889 patients with breast cancer, who had not received systemic treatment before surgery, and who underwent SLN biopsy and evaluation of all SLN by OSNA. The discrimination ability of the model was assessed by the area under the ROC curve (AUC ROC), and its calibration by comparing 5-years DFS Kaplan–Meier estimates in quartile groups of model predicted probabilities (MPP).

Results

The AUC ROC ranged from 0.78 (at 2 years) to 0.73 (at 5 years) in the training set, and from 0.78 to 0.71, respectively, in the validation set. The MPP allowed to distinguish four groups of patients with heterogeneous DFS (log-rank test p < 0.0001). In the highest risk group, the HR were 6.04 [95% CI 2.70, 13.48] in the training set and 4.79 [2.310, 9.93] in the validation set.

Conclusions

The model for the prediction of 5-year DFS was successfully validated using the most stringent form of validation, in centers different from those involved in the development of the model. The external validation of the model confirms its utility for the prediction of 5-year DFS and the usefulness of the TTL value as a prognostic variable.
Purification efficacy of different parts of Mangifera indica on water samples from contaminated drinking water sources in chanchaga local government area of Niger State, Nigeria
Authors: Okunlola Mary Banke , Ijah Udeme Josiah Joshua , Yisa Jonathan , Abioye Peter Olabisi , Ariyeloye Damola Stephen , Ibrahim Julius Ndayaman
Published: April 2020

The use of natural coagulant in water purification has gain popularities owing to the public health consequences of consuming untreated water and the carcinogenic properties of synthetic coagulant. In the present study, the leaf, stem, seed and bark powdered samplesMangifera indicawere used to treat contaminated river, stream and pond water at concentrations of 0.1, 0.2, 0.3, 0.4 and 0.5 g/L. Microbial quality and physicochemical properties of the water samples were investigated after 0, 12 and 24 h of treatment. The results showed that the addition ofM. indicaconsiderably decreases or even eliminated (in most cases) the aerobic heterotrophic bacteria, coliforms, salmonella and shigella in the water samples. All parts ofM. indicatested decreased the pH, dissolve oxygen, total dissolved solid, calcium, nitrate, turbidity and chemical oxygen demand contents of the water samples when compared with untreated water. The activities of the plant materials increase with increase treatment time and concentrations. In conclusion, the raw surface water (stream, river and pond) used for the study fall short of standard.Mangifera indicaleaf, stem, seed and bark materials improved the quality of the raw surface water based on the maximum permissible limit of microbial load and physicochemical parameters. This could serve as a cheaper and safer alternative to the synthetic coagulant.
Feasibility and Outcome of an Inpatient Interpersonal Skills Group for Older Adults (65+) With Acute or Chronic Depression
Authors: Bollmann Simon , Spies Jan , Hodzic Jadranko , Hohl-Radke Felix , Brakemeier Eva-Lotta
Published: April 2020

Abstract. In light of ongoing demographic changes, it is essential to tailor psychotherapeutic approaches and interventions to the specific needs and characteristics of older adults. An interpersonal skills group (ISG) for older adults consisting of modified Cognitive Behavioral Analysis System of Psychotherapy (CBASP) elements (Situational Analysis, Kiesler Circle Training) was integrated into the treatment schedule of an inpatient setting in routine clinical care. Feasibility and outcome were evaluated in a pilot study including 13 older patients ( Mage = 77.3, range 66–87 years) diagnosed with a major depressive disorder. Results indicate very good feasibility as well as a significant reduction of depressive symptoms in self-report measures and observer rating at discharge ( d = 1.00 to d = 5.62). No significant changes were observed in interpersonal distress, whereas significant changes in the Emotion Regulation Questionnaire (ERQ reappraisal: p < .001) and the Impact Message Inventory (IMI: p = .002 to p < .001) were reported and discussed. However, the results in the observer rating are likely to have been overestimated through a nonblinded rater. Further studies should examine the efficacy of age-tailored CBASP programs for older adults in large randomized controlled trials.
Induced Positive Affect Reduces the Magnitude of the Startle Response and Prepulse Inhibition
Authors: Ruiz-Salas Juan C. , De la Casa Luis G.
Published: April 2020

Abstract. The startle response is a reflex that represents a form of adaptation to environmental changes potentially relevant to survival. Startle magnitude can change depending on a number of factors such as the affective state of the organism during the presentation of the startle-inducing stimulus, or the so-called Prepulse Inhibition (PPI) that occurs when the startling stimulus (or Pulse) is preceded by a low-intensity stimulus (or Prepulse). This paper describes an experiment designed to analyze the impact of an induced positive affect on the magnitude of the startle response and PPI in adult humans. Specifically, each participant received alternating exposures to a picture of a face of a loved person (positive affect condition) or to a picture of a face of an unknown person (control condition) while the startle response and PPI were recorded. The results showed a decrease in both the magnitude of the startle response and percent PPI on the positive affect trials when compared with the control trials. These results are interpreted from psychophysiological and psychological perspectives considering the role of emotions in adaptive behavior.
Mantle and Recycled Oceanic Crustal Components in Mantle Xenoliths From Northeastern China and their Mantle Sources
Authors: Guo Peng , Ionov Dmitri A. , Xu Wen‐Liang , Wang Chun‐Guang , Luan Jin‐Peng
Published: April 2020

The subduction of the Paleo‐Pacific plate is widely credited for the destruction of the eastern North China Craton. However, how the Pacific plate subduction has affected the off‐craton lithospheric mantle in northeastern China is less clear, as few studies have focused on the lithospheric mantle‐derived xenoliths in that region. We report petrography, mineral and rock chemistry, and in situ isotopic compositions of Sr in clinopyroxene and O in olivine for 20 peridotite and 11 pyroxenite xenoliths hosted by the Cenozoic volcanic rocks at Jiaohe and Shuangliao localities. The peridotites include lherzolites, harzburgites, and a wehrlite, many are metasomatized. Group 1 garnet pyroxenites have high Al2O3, Ni, and Mg#; positive Eu and Sr anomalies; and olivine δ18O values of 4.8–5.1‰, which we attribute to recycling of oceanic crustal components to the asthenosphere and their reactions with host peridotites. Groups 2 and 3 pyroxenites are garnet‐free and contain peridotite‐like pyroxenes; we argue that they were formed by reactions of lithospheric peridotites with evolved melts derived from recycled oceanic crust. In addition, one pyroxenite contains orthopyroxene surrounded by fine‐grained olivine and clinopyroxene, while another pyroxenite and the wehrlite contain zoned clinopyroxene with gradual increases in Na2O, (La/Yb)N, Sr, and 87Sr/86Sr ratios and decreases in Ti/Eu from core to rim. These characteristics record infiltration of a carbonatite melt shortly before the transport of the xenoliths. The inferred carbonatite melt has 87Sr/86Sr ≥ 0.70415 and mantle‐like olivine δ18O and originated from carbonated asthenosphere. Our results, together with previous studies on the host basalts, suggest that subducted crustal materials were initially transported to the asthenosphere beneath northeastern China to produce carbonate‐bearing domains. Upwelling of the carbonated asthenosphere produced carbonatite melts that migrated upward and metasomatized the overlying lithospheric mantle.
Structural diversity of metal–organic frameworks based on a chalcone dicarboxylic acid ligand
Authors: Xu Hao , Zeng Xianghua , Pan Wei , Zhang Junyong , Cao Yangzheng , Guo Haiyang , Xie Jingli
Published: April 2020

Using chalcone dicarboxylic acid ligand, three MOFs have been obtained. Structural diversity and the photocatalytic properties for organic dyes have been observed.
Total synthesis of tricolorin Aviainterrupted Pummerer reaction-mediated glycosylation and one-pot relay glycosylation
Authors: Sun Jiuchang , Fang Jing , Xiao Xiong , Cai Lei , Zhao Xiang , Zeng Jing , Wan Qian
Published: April 2020

The total synthesis of tricolorin A was achieved with high efficiency based on interrupted Pummerer reaction-mediated (IPRm) glycosylation and one-pot relay glycosylation.
Promotion effect of urchin-like MnOx@PrOxhollow core–shell structure catalysts for the low-temperature selective catalytic reduction of NO with NH3
Authors: Cheng Shuyuan , Shao Jing , Huang Bichun , Guan Jinkun , Zhou Lusha
Published: April 2020

A MnOx@PrOxcatalyst with a hollow urchin-like core–shell structure was prepared using a sacrificial templating method and was used for the low-temperature selective catalytic reduction of NO with NH3.
Design,in silicostudies, and synthesis of new 1,8-naphthyridine-3-carboxylic acid analogues and evaluation of their H1R antagonism effects
Authors: Gurjar Vinod Kumar , Pal Dilipkumar
Published: April 2020

New 1,8-naphthyridine-3-carboxylic acid derivatives were designed, synthesized and evaluated for theirin vivoantihistaminic activity on guinea pig trachea by using chlorpheniramine maleate as the standard drug.
Defect-induced nucleation and epitaxial growth of a MOF-derived hierarchical Mo2C@Co architecture for an efficient hydrogen evolution reaction
Authors: Zhang Linfei , Zhu Jingting , Shi Yumeng , Wang Zhuo , Zhang Wenjing
Published: April 2020

In this work, we report a new strategy to synthesize efficient 3D hierarchical catalysts composed by Mo2C nanosheets and Co nanoparticles (H-Mo2C@Co). The Mo2C and Co makes a synergistic effect in improving HER via providing large surface areas.
Synthesis and antibacterial activity of iron manganite (FeMnO3) particles against the environmental bacteriumBacillus subtilis
Authors: Vasiljevic Zorka Z. , Dojcinovic Milena P. , Krstic Jugoslav B. , Ribic Vesna , Tadic Nenad B. , Ognjanovic Milos , Auger Sandrine , Vidic Jasmina , Nikolic Maria Vesna
Published: April 2020

Iron manganite (FeMnO3) particles express antibacterial activity againstBacillus subtilis, together with H2O2release and Fe, Mn-ion release in LB bacterial medium.
Rhodium-catalyzed phosphorylation reaction of water-soluble disulfides using hypodiphosphoric acid tetraalkyl esters in water
Authors: Arisawa Mieko , Fukumoto Kohei , Yamaguchi Masahiko
Published: April 2020

RhCl3catalyzed the phosphorylation reaction of water-soluble disulfides, including unprotected glutathione disulfide, with hypodiphosphoric acid tetraalkyl esters in homogeneous water.
The movements of Alpine glaciers throughout the last 10,000 years as sensitive proxies of temperature and climate changes
Authors: Kutschera Walter , Patzelt Gernot , Schaefer Joerg M. , Schlüchter Christian , Steier Peter , Wild Eva Maria
Published: April 2020

A brief review of the movements of Alpine glaciers throughout the Holocene in the Northern Hemisphere (European Alps) and in the Southern Hemisphere (New Zealand Southern Alps) is presented. It is mainly based on glacier studies where 14C dating, dendrochronology and surface exposure dating with cosmogenic isotopes is used to establish the chronology of advances and retreats of glaciers. An attempt is made to draw some general conclusions on the temperature and climate differences between the Northern and Southern Hemisphere.
Shell evolution and isomers below 132Sn: Spectroscopy of neutron-rich 46Pd and 47Ag isotopes
Authors: Watanabe Hiroshi
Published: April 2020

Neutron-rich isotopes of Pd (Z = 46) and Ag (Z = 47) have attracted considerable interest in terms of the evolution of the N = 82 shell closure and its influence on the r-process nucleosynthesis. Such previously unreachable exotic nuclides have become accessible by means of in-flight fission of a high-intensity 238U beam available at a new-generation radioactive isotope (RI) beam facility, the RI Beam Factory (RIBF) in RIKEN Nishina Center. In this report, recent spectroscopic results of Pd and Ag isotopes obtained as part of the EURICA (EUROBALL-RIKEN Cluster Array) project at RIBF are presented.
Untersuchung zur Wirkung von Kinesio-Tape und IQ-Tape auf die neuromuskuläre Aktivität beim Joggen, Treppensteigen und Drop-Jump
Authors: Rogan Slavko , Baur Heiner
Published: April 2020

Hintergrund Applikationen mit elastischem Tape werden positive Wirkungen auf die Bewegung zugeschrieben. Unter anderem werden Attribute wie stoffwechselanregend, entstauend, kräftigend und schmerzlindernd genannt. Das Ziel dieser Interventionsstudie mit einem Within-Subject-Design war die Untersuchung verschiedener elastischer Tapes (Kinesiotape – KT, IQ-Tape – IQ, ohne Tape: OT) auf die neuromuskuläre Aktivierung der Beuge- und Streckkette der unteren Extremität während des Joggens, des Treppensteigens und bei Drop Jumps.

Probanden/Methodik Achtzehn gesunde Erwachsene (5 Männer und 13 Frauen) mit einem Durchschnittsalter von 26,3 ± 3,6 Jahren und einem Body-Mass-Index von 22,3 ± 0,7 kg/m2 wurden rekrutiert. Die Teilnehmer absolvierten Laufintervalle mit 10 km/h, 12 km/h und 15 km/h, Treppensteigen und Drop Jumps (10 Versuche). Die Muskelaktivierung des M. vastus medialis und M. vastus lateralis, des M. bizeps femoris, des M. semitendionosus, des M. tibialis anterior, M. gastrocnemius medialis und lateralis wurden erhoben, um das Verhältnis der Muskelaktivierung des M. tibialis anterior zu M. gastrocnemius medialis und lateralis (T/G-ratio) und des M. vastus medialis und lateralis zum M. bizeps femoris und M. semitendinosus (V/I-ratio) zum Zeitpunkt vor (–150 bis 0 ms pre), während (0–30 ms post) und von 30 ms bis 150 ms post der ersten Bodenkontaktaufnahme mit Hilfe elektromyografischer Messungen darzustellen. Die statistische Prüfung erfolgte mittels des nonparametrischen L-Puri-Sen-Verfahrens. Das Signifikanzniveau wurde auf p < 0,05 gesetzt.

Ergebnisse Zwei Probanden schieden während der Datenaufnahme aus der Studie aus. Damit konnten von 16 Probanden Daten analysiert werden. Beim Treppenheruntersteigen zeigt IQT in der Voraktivierung (–150 bis 0 ms) vor dem ersten Bodenkontakt einen signifikant erhöhten T/G-ratio im Vergleich zu OT (p = 0,01). Die restlichen Vergleiche von Applikationen mit KT, IQT und OT ergaben keine signifikanten Unterschiede (p > 0,05).

Schlussfolgerung Es kann davon ausgegangen werden, dass Kinesiotape – KT und IQ-Tape – IQ keine relevanten detektierbaren Änderungen der Muskelaktivierung bei gesunden Personen hervorrufen. Zukünftige Studien sollten Patienten einschließen, die eine pathologisch veränderte neuromuskuläre Kontrolle aufweisen.
Raman spectra investigation on the pressure-induced phase transition in titanium nitride (TiN)
Authors: Cheng Peng , Ye Tingting , Zeng Hong , Ding Junfeng
Published: April 2020

Titanium nitride (TiN) exhibits extremely high wear resistance and corrosion resistance, leading to a broad range of applications. Despite the extensive theoretical efforts on the structural stability of TiN under pressure, a few experimental observations of the pressure-induced phase transition through x-ray diffraction are still in debate. Here, the Raman spectra of TiN under pressure are studied in a diamond anvil cell up to 36 GPa. The discontinuity in the pressure dependent phonon frequencies suggests a phase transition at around 5 GPa with the bonding between Ti and N hardly changing. The phase transition is ascribed to an isostructural transition or a vacancy filling mechanism.
Broadband critical dynamics in disordered lead-based perovskites*
Authors: Stock C , Songvilay M , Gehring P M , Xu Guangyong , Roessli B
Published: April 2020

Materials based on the cubic perovskite unit cell continue to provide the basis for technologically important materials with two notable recent examples being lead-based relaxor piezoelectrics and lead-based organic–inorganic halide photovoltaics. These materials carry considerable disorder, arising from site substitution in relaxors and molecular vibrations in the organic–inorganics, yet much of our understanding of these systems derives from the initial classic work of Prof. Roger A Cowley, who applied both theory and neutron scattering methods while at Chalk River Laboratories to the study of lattice vibrations in SrTiO3. Neutron scattering continues to play a vital role in characterizing lattice vibrations in perovskites owing to the simple cross section and the wide range of energy resolutions achievable with current neutron instrumentation. We discuss the dynamics that drive the phase transitions in the relaxors and organic–inorganic lead-halides in terms of neutron scattering and compare them to those in phase transitions associated with a ‘central peak’ and also a soft mode. We review some of the past experimental work on these materials and present new data from high-resolution time-of-flight backscattering spectroscopy taken on organic–inorganic perovskites. We will show that the structural transitions in disordered lead-based perovskites are driven by a broad frequency band of excitations.
Bend monitoring and refractive index sensing using flat fibre and multicore Bragg gratings
Authors: Holmes Christopher , Ambran Sumiaty , Cooper Peter A , Webb Andrew S , Gates James C , Gawith Corin B E , Sahu Jayanta K , Smith Peter G R
Published: April 2020

A planarized optical fibre designed for two-dimensional bend monitoring and external refractive index sensing is presented. The approach uses two single-mode waveguides each containing a set of spectrally multiplexed Bragg gratings. To achieve sensitivity to bending and external refractive index, the cladding material of the fibre is partially removed through physical machining. This acts to offset the neutral axis, increasing bend sensitivity, and exposes the evanescent field of the guided mode, permitting external refractive index monitoring. Through collective monitoring of the Bragg grating array, real time, multiparameter sensing is attainable, allowing new capability for intelligent monitoring.
Rapid growth of large area graphene on glass from olive oil by laser irradiation
Authors: Huang Yihe , Sepioni Margherita , Whitehead David , Liu Zhu , Guo Wei , Zhong Xiangli , Gu Heng , Li Lin
Published: April 2020

Although homogeneous, high quality graphene can be fabricated on a Cu or Ni sheet using the traditional chemical vapour deposition method at high temperatures (over 1000 °C) under specific atmospheric conditions, their transfer to another substrate is difficult. In this paper a novel method of rapidly (i.e. 3–6 s of laser irradiation) producing a large area (>3 cm2) graphene film from olive oil on a glass surface (pre-coated with a 5–28 nm thick Ni film) with defocused, large area continuous laser irradiation is described. The turbostratic graphene film (6 layers) grown in such a way has shown high electrical conductivity (sheet resistance of around 20 Ω sq−1) and an optical transmittance of 40–50%. With femtosecond laser patterning, 70% optical transparency was demonstrated. Continuous large area graphene was formed at relatively lower temperatures (<250 °C) and without the need for specific atmospheric conditions. The basic process characteristics and mechanisms involved are discussed.
Unrecognized Hemoglobin Variants in the Donor Blood Supply Are Detectable in the Transfused Population
Authors: Rutherford-Parker Nicola J , Colby Jennifer M , Gehrie Eric A , Booth Garrett S
Published: April 2020

Objectives

The US Food and Drug Administration requires donated blood to be tested for various infectious diseases to ensure safety and purity. However, testing for hemoglobin variants is not required, despite reported occurrences of hemoglobin variant transfusion and concerns about the safety of such transfusions. This study aimed to investigate the frequency of hemoglobin variants within the blood supply.

Methods

We performed a 2-part study. First, we tested all RBC units in our blood bank by high-performance liquid chromatography for the presence of hemoglobin variants. Second, we performed a retrospective analysis of hemoglobin variant testing completed for routine management of sickle cell disease patients at our institution over a 5-month period to identify cases of hemoglobin variant transfusion.

Results

We found that 2 of 476 (0.4%) RBC units in our blood bank contained a hemoglobin variant, and 5 of 563 (0.9%) sickle cell patients seen at our institution in a 5-month period were transfused with RBCs containing a hemoglobin variant.

Conclusions

We confirmed that hemoglobin variants are present within the blood supply, and the frequency of hemoglobin variant transfusion is elevated for patients with sickle cell disease given the increased prevalence of hemoglobin variants in the population of matched donors.