bluuebunny/crossref_metadata_2025 huggingface dataset:
Digital Collection Transformation At The Library of National Cheng Kung University Taiwan: An Evaluation
Authors: Fridayani Helen Dian , Iqbal Muhammad
Published: December 2022

Abstract

 Background: This paper evaluates digital collections and investigates digital collection transformation at National Cheng Kung University's Central Library in Taiwan. The NCKU case study highlights some issues that must be addressed, such as analyzing user information, improving library capacity and skills, developing digital resources, funding IT infrastructure development, and long-term database development for E-learning. Purpose:  The goal of this study is to assess the readiness of the library collection center's planning for digital transformation, from the user perspective, students in particularly. Method: qualitative descriptive research method and supported by survey data conducted by NCKU. Result: The findings indicate that users are ready for the library collection center's digital transformation. However, the digital library collection center necessitates more careful planning, particularly in terms of socialization. Conclusion: Digital library's rich digital information and digital learning materials enable users to study and research at any time and from any location, in the format of lifelong learning and personalized learning. Libraries are considered the heart of any higher education institution and play a significant role.

 Keywords: Digital, Library, Acceptance of Technology, Transformation

 

Abstrak

 Latar Belakang: Artikel ini mengevaluasi koleksi digital dan menyelidiki transformasi koleksi digital di Perpustakaan Pusat Universitas Nasional Cheng Kung di Taiwan. Studi kasus NCKU menyoroti beberapa masalah yang harus ditangani, seperti menganalisis informasi pengguna, meningkatkan kapasitas dan keterampilan perpustakaan, mengembangkan sumber daya digital, mendanai pengembangan infrastruktur TI, dan pengembangan basis data jangka panjang untuk E-learning. Tujuan: Untuk menilai kesiapan perencanaan koleksi perpustakaan untuk transformasi digital, baik dari perspektif pengguna terutama mahasiswa. Metode: Dengan menyebarkan survei ke berbagai sumber dan responden, penelitian ini menggunakan metode penelitian deskriptif kualitatif dan didukung oleh data survei yang dilakukan oleh NCKU. Hasil: Temuan menunjukkan bahwa pengguna siap untuk transformasi digital pusat koleksi perpustakaan. Pusat koleksi perpustakaan digital memerlukan perencanaan yang lebih matang, terutama dalam hal sosialisasi. Kesimpulan: Informasi digital perpustakaan digital yang kaya dan materi pembelajaran digital memungkinkan pengguna untuk belajar dan meneliti kapan saja dan dari lokasi mana pun, dalam format pembelajaran seumur hidup dan pembelajaran yang dipersonalisasi. Perpustakaan dianggap sebagai jantung dari setiap institusi pendidikan tinggi dan memainkan peran penting.

Kata kunci: Koleksi Digital; Perpustakaan; Penerimaan Teknologi; Transformasi
Perspektif Perilaku Konsumen dalam Penggunaan Aplikasi Belanja Online Lazada (Studi Kasus Pada Mahasiswa Desa Sungai Perpat Inhil Riau)
Authors: Fitriani Dewi
Published: December 2022

Penelitian  Perpspektif  Perilaku Konsumen dalam Penggunaan Aplikasi Belanja Online Lazada( Studi kasus pada mahasiswa Desa Sungai Perpat). Metode  yang digunakan dalam penelitian ini adalah metode  kualitatif karna data penelitian bukan berupa angka-angka metode penelitian kualitatif merupakan metode yang digunakan untuk melakukan penelitian yang berorientasi pada gejala gejala yang bersifat alamiah. Teknik pengumpulan data yang digunakan dalam penelitian ini yaitu: Penyebaran angket, wawancara, observasi serta triangulasi. Sebagai subjek penelitian adalah mahasiswa Desa Sungai Perpat yang menggunakan aplikasi belanja online Lazada dengan keseluruhan 10 orang responden dari penyebaran angket dan 5 orang informan dari wawancara. Berdasarkan hasil penelitian yang didapatkan dari penyebaran angket bahwa yang mempengaruhi responden dalam menggunakan aplikasi belanja online Lazada yaitu kemudahan, kepuasan, motivasi dan keamanan.
Kata Kunci: Perilaku Konsumen, Belanja Online, Aplikasi Belanja Online
Overview Laporan Keuangan UPK Mitra Mandiri di Kec. Pragaan, Sumenep, Madura
Authors: Aprilia Firda Alfaini , Agustina Rachma
Published: December 2022

Laporan keuangan adalah suatu bentuk penyampaian, pemberitahuan ataupun pertanggungjawaban yang berisi tentang informasi keuangan suatu perusahaan untuk menggambarkan kinerja perusahaan tersebut. SAK ETAP atau standar akuntansi keuangan untuk entitas tanpa akuntabilitas publik merupakan standar akuntansi yang digunakan oleh entitas yang tidak memiliki akuntabilitas signifikan dan dan menerbitkan laporan keuangan untuk tujuan yang umun. Tujuan dari kegiatan pengabdian ini adalah mengetahui hasil implementasi laporan keuangan berbasis SAK ETAP pada UPK Mitra Mandiri di Kecamatan Pragaan Sumenep Madura. Metode yang digunakan dalam penelitian ini adalah campuran karena didalamnya berfokus pada pengumpulan, analisis, dan pencampuran data kuantitatif dan kualitatif dalam satu studi atau serangkaian studi.
Kata kunci: Laporan Keuangan, SAK ETAP, Unit Pengelola Kegiatan
Pelatihan Alat Evaluasi Berbasis Hots Bagi Guru MGMP Daring dan Pemasaran Kabupaten Magetan
Authors: Sudarwanto Tri , Harti  , Saino  , Sulistyowati Raya
Published: December 2022

Abstrak memuat uraian singkat mengenai masalah dan tujuan penelitian, metode yang digunakan, dan hasil penelitian. Tekanan penulisan abstrak terutama pada hasil penelitian. Abstrak ditulis dalam bahasa Indonesia dan Bahasa Inggris. Pengetikan abstrak dilakukan dengan spasi tunggal dengan margin yang lebih sempit dari margin kanan dan kiri teks utama. Kata kunci perlu dicantumkan untuk menggambarkan ranah masalah yang diteliti dan istilah-istilah pokok yang mendasari pelaksanaan penelitian. Kata-kata kunci dapat berupa kata tunggal atau gabungan kata. Jumlah kata-kata kunci 3-5 kata.  Kata-kata kunci ini diperlukan untuk komputerisasi. Pencarian judul penelitian dan abstraknya dipermudah dengan kata-kata kunci tersebut.

Kata Kunci: Isi, Format, Artikel
FINPLAN: STRATEGI MENUJU KELUARGA SEJAHTERA
Authors: Pertiwi Dwi Ari , Agustina Rachma , Ardiana Meta
Published: December 2022

Masalah utama sebuah keluarga yang selalu ada biasanya seputar keuangan, pengelolaan  keuangan merupakan hal yang sangat penting dalam menjaga stabilitas ekonomi dalam sebuah keluarga, dengan pengelolaan keuangan yang terencana akan berdampak kesuksesan bagi keluarga dan kemudahan dalam mencapai tujuan financial. Metode pelaksanaan Program Pengabdian Masyarakat dengan pemberian ceramah dan pelatihan perencanaan keuangan secara mudah dan sederhana. Kegiatan pengabdian ini diawali dengan analisis situasi permasalahan yang terjadi pada lembaga mitra atau obyek pengabdian, selanjutnya diteruskan dengan pengkajian literatur sesuai dengan permasalahan yang diberikan solusi melalui program PKM.
'Aloof's Ramp', 'Jardin de Glynn': Gibraltar's street names and an eighteenth-century Western Mediterranean spatial practice
Authors: Wright Laura , Weston Daniel
Published: December 2022

We will be talking about why Gibraltar’s assemblage of historic English and Gibraltar Spanish streetnames is unique. The personal-names within Gibraltar’s streetnames were borne by an eighteenth- and early nineteenth-century community of practice who specialised in servicing Western Mediterranean forts. We count about 70 civilian personal-names in Gibraltar’s (official) historic English streetnames (predominantly of English, Genoese, Moroccan-Sephardic, Menorcan origin) and about 30 in Gibraltar’s (unofficial, but still historic) Spanish streetnames, which unsurprisingly contain Spanish surnames too. Thus Gibraltar streetnames provide archaeological trace of this Western Mediterranean economic workforce, not apparent in streetnames elsewhere.
Las pinturas murales de la capilla de Jesús de Moguer: una obra de Miguel Ollero Márquez
Authors: Ollero Lara Sergio
Published: December 2022

La capilla de Jesús fue erigida a finales del siglo XV sobre uno de los puntos más altos de la villa de Moguer. A lo largo de los siglos ha sufrido importantes remodelaciones auspiciadas por algunos indianos como Pedro Gupil de Herrera, pero también por la propia labor de la cofradía de Nuestro Padre Jesús Nazareno. En el siglo XX comienza un ambicioso proyecto de adecentamiento y enriquecimiento pictórico ideado por el artista Miguel Ollero Márquez, que incluye el camarín y el presbiterio de la capilla, y que supone uno de los conjuntos murales más asombrosos de la provincia de Huelva.
Derribando al Almirante: la idealización de Cristóbal Colón como precondición para un contragolpe cultural
Authors: Hill Alberta Frances
Published: December 2022

Este artículo propone una relación directa entre el debate que surgió durante la Ilustración sobre las implicaciones éticas, sociopolíticas, y económicas del descubrimiento de América, y la actual reacción negativa contra Cristóbal Colón y su legado. La idea al núcleo de esta polémica era que el descubrimiento de América había tenido repercusiones catastróficas tanto para los pueblos indígenas del continente como para Europa, y que había sido un error enorme. También propongo que la condenación pública de Colón, que ha resultado en el vandalismo o destrucción de monumentos públicos y campañas exitosas para renombrar el Día de Colón en honor de los pueblos indígenas, es una reacción a un proyecto literario e iconográfico de una esencia propagandística, que fue iniciado antes de la Guerra de Independencia de los Estados Unidos y que planteó a Colón como un héroe nacional y el primero de los padres fundadores. Demostraré como la representación idealizada de Colón, que fue consolidada a lo largo del siglo XIX mediante la literatura, el arte, y materiales didácticos como manuales escolares, y que, hasta la década pasada, apenas fue cuestionada en la esfera pública, y que la hegemonía de esta imagen artificial la convirtió en un blanco prominente para un contragolpe cultural. Mientras otros investigadores han abordado diestramente la controversia antiamericana que enredó la comunidad intelectual en ambos lados del Atlántico durante la Ilustración, además del desarrollo de la iconografía colombina en el contexto de los siglos XVIII y XIX, su papel clave en la creación de las condiciones para una reevaluación de la función de la Colón en la historia norteamericana todavía no ha sido investigado completamente.
Produktivitas Karya Ilmiah Dosen UIN KHAS Jember Pada Jurnal Terindeks Scopus
Authors: Mafar Fiqru
Published: December 2022

This article examines the productivity of the scientific work of UIN KHAS Jember lecturers in Scopus indexed journals. The method used is the descriptive method with bibliometric analysis. The VOSviewer application is used in the bibliometric study to make it easier to visualize the results found. The results show an inconsistency in the naming of UIN KHAS Jember affiliations on Scopus. The highest productivity occurred in 2020 with 37 scientific papers produced by lecturers. The subject area of â€‹â€‹most articles falls under the social sciences area. Most of the scientific work produced is available in open access form. In contrast to productivity based on the year of publication, the highest citation occurred in 2021. Meanwhile, the lecturer with the most scientific work productivity is Mukhlis, M. Not all scientific works produced result from lecturer collaboration. However, for lecturers who have collaborated, cooperation is carried out through collaboration with various institutions within and outside the country. Students are the terms that appear the most based on the keywords used. 

Artikel ini mengkaji produktivitas karya ilmiah dosen UIN KHAS Jember pada jurnal terindeks Scopus. Metode yang digunakan adalah metode deskriptif dengan analisa bibliometrik. Aplikasi VOSviewer digunakan dalam Analisa bibliometric guna memudahkan membuat visualisasi terhadap hasil yang ditemukna Hasil penelitian menunjukkan bahwa terdapat inkonsistensi penamaan afiliasi UIN KHAS Jember pada Scopus. Produktivitas tertinggi terjadi pada tahun 2020 dengan 37 karya ilmiah yang dihasilkan oleh para dosen. Area subjek artikel paling banyak masuk di bawah wilayah social sciences. Sebagian besar karya ilmiah yang dihasilkan tersedia dalam bentuk akses terbuka. Berbeda dengan produktivitas berdasarkan tahun terbit, sitasi tertinggi terjadi pada tahun 2021. Sedangkan dosen dengan produktivitas karya ilmiah terbanyak adalah Mukhlis, M. Belum semua karya ilmiah yang dihasilkan merupakan hasil dari kolaborasi dosen. Meskipun demikian, bagi para dosen yang telah berkolaborasi, kolaborasi dilaksanakan melalui kerjasama dengan berbagai lembaga baik dari dalam maupun luar negeri. Berdasarkan kata kunci yang digunakan, students merupakan istilah yang paling banyak muncul.
Analisis Framing Pemberitaan Vaksin Covid-19 Oxford-Astrazeneca di Indonesia
Authors: Subakti Dian Rahmawati , Waluyo Lukman Saleh
Published: December 2022

There are several online news sites in Indonesia, such as Kompas.com and Tempo.com. In reporting on COVID-19, especially information on vaccine developments, both media such as Kompas.com and Tempo.com each frame the information obtained and then publish it to shape the public perception expected from these media, especially in shaping the perception of readers. Against the COVID-19 vaccine. This research method uses a qualitative approach with data collection techniques documented and analyzed using the framing model developed by Pan & Kosicki. The results showed that syntactically the framing of Kompas.com news from headlines, leads, quotes, and closings contained many AstraZeneca vaccine plans and its research updates that contained pros and cons for consumption. Moreover, the closing contains much research on the AstraZeneca vaccine, which is suitable for consumption and should be carried out by the community.

Terdapat beberapa situs laman berita daring di Indonesia, sebut saja Kompas.com dan Tempo.co. Pada pemberitaan tentang COVID-19, terutama informasi perkembangan vaksin, kedua media, seperti Kompas.com dan Tempo.co, masing-masing membingkai informasi yang didapat untuk kemudian dipublikasikan agar dapat membentuk persepsi publik yang diharapkan dari media-media tersebut, terutama dalam membentuk persepsi pembaca terhadap vaksin COVID-19. Metode penelitian ini menggunakam pendekatan kualitatif dengan teknik pengumpulan data secara dokumentasi dan dianalisis menggunkan model framing yang dikembangkan oleh Pan & Kosicki. Hasil penelitian menunjukan bahwa secara sintaksis framing pemberitaan Kompas.co dari headline, lead, kutipan, serta penutup, banyak memuat tentang rencana vaksin AstraZeneca berikut pembaruan penelitiannya yang memuat pro dan kontra untuk di konsumsi, sedangkan pemberitaan Tempo.co dari headline, lead, kutipan, serta penutup, banyak memuat tentang penelitian vaksin AstraZeneca yang sebenarnya layak untuk dikonsumsi dan sebaiknya dilaksanakan oleh masyarakat.
Parenting Communication: Penerapan Komunikasi Empatik dalam Pola Pengasuhan Anak
Authors: Muzzammil Faisal Muzzammil
Published: December 2022

Pola pengasuhan anak atau parenting dalam suatu kelurga sangat dipengaruhi oleh proses dan alur komunikasi yang dibangun orang tua kepada anaknya. Agar proses pengasuhan anak dapat terlaksana secara efektif, aplikatif dan komunikatif, maka dapat menerapkan prinsip komunikasi empatik. Berdasarkan latar belakang tersebut, maka studi ini bertujuan untuk mengungkap lebih dalam tentang: (1) Parenting Style: Ragam Gaya dan Pola Pengasuhan Anak; (2) Parenting Communication: Komunikasi Empatik dalam Pola Pengasuhan Anak. Didasarkan atas hasil analisis dan pembahasan, maka ada dua temuan utama dalam studi ini, yaitu: (1) Pola asuh intelektual-otoritatif-atentif merupakan parenting style yang relevan, aktual dan kontekstual diterapkan dalam proses pengasuhan anak di masa sekarang ini; (2) Ada empat prinsip komunikasi empatik yang dapat diterapkan dalam pola pengasuhan anak, yakni memperhatikan anak, mendengarkan anak, memahami anak dan menghargai anak.
Analisis Makna Pesan Motivasi dalam Lirik Lagu 21st Century Girls
Authors: Febrianty Liris , Irawan Windra
Published: December 2022

BTS (Bangtan Sonyeondan) adalah sebuah boy band yang asalnya dari Korea Selatan dan namanya sudah tidak asing lagi terdengar bagi semua orang di dunia. Prestasi dan personal branding yang kuat, membuat BTS sangat dikenal semua orang.  Dalam membuat karya musiknya, para penggemar selalu dikejutkan dengan skill mereka dalam penulisan lirik yang selalu memberikan banyak makna, entah itu tentang perjalanan karir mereka atau tentang isu-isu sosial. Karya ilmiah ini dibuat dengan judul “Analisis Makna Pesan Motivasi yang Tersirat Bagi Perempuan Di Dunia dari Lirik Lagu 21st Century Girls karya Boy Band Korea Selatan : BTS (Bangtan Sonyeondan)”. Penelitian menggunakan penelitian kualitatif interpretatif dan dianalisa melalui teori semiotika Ferdinand De Saussure dengan tujuan untuk menjelaskan pesan motivasi dari lirik lagu tersebut yang dijabarkan perbait. Peneliti memilih lagu ini karena lagu 21st Century Girls karya BTS adalah sebuah lagu yang sangat inspiratif dengan mengangkat isu-isu sosial pada perempuan tentang kepercayaan diri seorang perempuan. Dapat diketahui, kepercayaan diri perempuan cenderung menurun karena standar kecantikan masyarakat yang tinggi. Dalam penelitian inilah ditemukan makna pesan motivasi bagi perempuan yang terlibat dalam masalah kepercayaan diri.
Implementasi Kebijakan Penanggulangan Bencana Kebakaran Hutan dan Lahan di Kabupaten Ogan Ilir Tahun 2019
Authors: Ayu Wulandari Ajeng , Isabella Isabella , Febriyanti Doris
Published: December 2022

The purpose of this research is to find out how to implement forest and land fire disaster management policies in Ogan Ilir. The research method used in this research is qualitative research. The results show that by using Edward III's theory to analyze there are four indicators, including Communication, Resources, Disposition, and Birocration. First is communication, information delivery is only in the form of banners and banners that are installed near village settlements. Second, resources are also sufficient to consist of 110 Regional Disaster Management Agency personnel and 28 volunteers. Third, Disposition, this indicator is the lack of responsiveness given by the personnel of the Village Task Force and the Subdistrict Task Force to the community in Palemraya Village when forest and land fires occur. Fourth, Bureaucratic Structure, on this indicator the author finds irregularities in the bureaucratic structure, this can be seen from the disaster management procedures which are too convoluted and a waste of time. Based on the results of the research and discussion, it can be concluded that the Implementation of the Forest and Land Fire Disaster Management Policy in Ogan Ilir Regency in 2019 has gone well although there are several obstacles faced by the Ogan Ilir Regency Regional Disaster Management Agency and the parties in the implementation of the policy. However, all can be overcomed. Suggestions in this study are the Regional Disaster Management Agency of Ogan Ilir Regency can provide socialization to the community, can minimize the flow of procedures in handling fire disasters and the Regional Disaster Management Agency of Ogan Ilir Regency can further improve responsiveness in the field when a fire occurs.
Partisipasi Dalam Kerangka Program Pemolisian Masyarakat Menuju Masyarakat Aman: Tinjauan Naratif
Authors: Salmon Indra Pratama Putra
Published: December 2022

The development of modernization and global dynamics basically brings a comprehensive impact on the socio-economic and cultural life of the community. In addition to being a shared goal, it also has a negative impact on society. This study uses a literature study methodology with a narrative analysis approach. The study uses data, theoretical literature, and previous studies as strengths in writing analysis. The results of the study show that technological developments have both positive and negative impacts on society, such as poverty, inequality, and other social ills. The impact was running which initially took place in urban areas, then continued in rural areas considering the trends that occurred in urban areas began to enter and develop in rural areas. On the other hand, the limitations of stakeholders (in this case the police) demand synergy with groups outside of these stakeholders, which in this case is the involvement of the community to contribute to creating stability, security and environmental order. In this regard, the community policing strategy becomes an alternative in overcoming and overcoming disturbances and threats to security and public order. The urgency and contribution of this study is that it is important to carry out community policing efforts to overcome criminal acts and even crimes in the community that can cause losses and damage in practice.
Nutritional evaluation, phytochemical makeup, antibacterial and antioxidant properties of wild plants utilized as food by the Gaddis-a tribal tribe in the Western Himalayas
Authors: Thakur Arti , Singh Somvir , Dulta Kanika , Singh Nitesh , Ali Baber , Hafeez Aqsa , Vodnar Dan C. , Marc Romina Alina
Published: December 2022

Nowadays, it is generally accepted that medicinal plants play a crucial role in traditional healthcare operations, providing hints to new research fields and in biodiversity protection. However, there is a lack of information on the medicinal uses of plants in many of the interior Himalayan regions. In light of this, the current investigation was initiated in the tribally dominant western Himalayan hinterland. The current study examined five underutilized wild edible plants, namely, Allium rubellum, Berberis chitria, Capsella bursa-pastoris, Stellaria aquatica, and Rheum emodi, for their nutritional qualities, phytochemical analysis, antioxidant activity, and antibacterial activity, which are consumed as food by the Gaddi community of the Bharmour region of the Chamba District, Himachal Pradesh. In this study, the nutritional makeup of these plants was examined in terms of their carbohydrate, protein, sodium, potassium, crude fiber, and fat content. As compared to other investigated species, A. rubellum has the highest nutritional content: carbohydrate (6.93 mg/g), protein (10.18 mg/g), sodium (3.21 mg/g), potassium (16.32 mg/g), and fiber (6.46%). In addition, phenols, amino acids, tannins, terpenoids, carotenoids, and phytate were found to be the least significant phytochemicals in R. emodi, i.e., 4.81 mg/g, 0.594 mg/g, 2.204 mg/g, 1.482 mg/g, 156 µg/g, and 0.680%, respectively. The methanolic extract of these wild edible plants showed significant free radical scavenging activity by using ABTS and DPPH assays. Moreover, the antibacterial activity of the methanolic extract of studied plants based on the present study suggested that R. emodi exhibits a maximum zone of inhibition of 20.8 mm against Escherichia coli, whereas S. aquatica showed a maximum inhibition zone of 19.2 mm against S. aureus. The findings of this study validated that these wild edible plants are an alternate source of medicine and are an abundant source of various phytochemicals like protein, carbohydrates, vitamins, and minerals. These compositions offer dietary benefits, food security, health benefits, and therapeutic advantages. Hence, in the current study, it was analyzed that there is an urgent need for documentation, conservation, characterization, and evaluation of these underutilized plants for their therapeutic purpose and nutritional supplements.
Self-assembled/composited lignin colloids utilizing for therapy, cosmetics and emulsification
Authors: Bai Yating , Wang Xing , Wang Xinru , Yang Xujie , Li Xinke , Xin Hanwen , Sun Dayin , Zhou Jinghui
Published: December 2022

Lignin, the most abundant source of renewable aromatic compounds on the planet, is attracting more scholarly attention due to its possibility of replacing petroleum-based chemicals and products. However, it remains underutilized because of the heterogeneity of its multi-level structure that prevents homogenization and standardization of derived products. The key to solving these problems lies in finding a general preparation method to achieve the integrated utilization of lignin molecules at all levels. The assembly-mediated granulation methods provide a significant means for the integrated value-added utilization of lignin, and for biomass productization applications, it is significant to understand the molecular mechanisms of lignin nano-colloids (LNCs) formation thus accurately guiding their functionalization. Therefore, a thorough understanding of the assembly morphology and behavior of lignin in different solutions towards colloids is of great scientific importance. In this minireview, we focus on the assembly behavior of lignin in different solvents, specifically in mono-solvent and multi-solvent, and in particular, we review various methods for preparing lignin composite colloids and concentrate on the applications in therapy, cosmetics and emulsification, which are important for guiding the preparation and efficient utilization of LNCs.
The role of media professionals in perpetuating and disrupting stereotypes of women in Science, Technology, Engineering and Math (STEM) fields
Authors: Corsbie-Massay Charisse L'Pree , Wheatly Michele G.
Published: December 2022

Women continue to be underrepresented in the Science, Technology, Engineering and Mathematics (STEM) fields despite efforts to enhance interest and persistence at all levels in the educational pipeline. The “chilly” climate documented for girls and women in STEM exists within a broader communication climate established and reinforced by media professionals. The present study examined the role of media professionals in perpetuating stereotypes of women in STEM through two approaches (1) conducting interviews with seventeen STEM women about their engagement with media professionals and (2) surveying 105 media professionals about their stereotypes about science and scientists. STEM women report positive interactions with the media despite incidents of unprofessionalism, dissonance between the processes and pace of science vs. the media, an undercurrent of issues pertaining to gender and other forms of representation, and an ethical responsibility to engage with media. The survey of media professionals revealed persistent stereotypes about scientists across both genders, and these stereotypes were more pronounced among those who engaged with science as part of their job, particularly among those working in entertainment and advertising and those working outside of journalism and social media. To establish greater equity in STEM fields and the knowledge pipeline, communication scholars must investigate the role of media professionals in this process and consider best practices to disrupt media stereotypes about STEM women.
Effect of ApoE ε4 gene polymorphism on the correlation between serum uric acid and left ventricular hypertrophy remodeling in patients with coronary heart disease
Authors: Liu Jia , Zheng Mei-Li , Chen Mulei , Li Kuibao , Zhu Xiaoming , Gao Yuanfeng
Published: December 2022

Background

Hyperuricemia and dyslipidemia are associated with left ventricular hypertrophy (LVH), while the effect of ApoE gene polymorphism on the correlation between serum uric acid (UA) level and severity of LVH in patients with coronary heart disease (CHD) has not been clarified.

Methods

This was a retrospective observational study of patients with CHD. Patients were divided into groups of ε4 carriers and non-ε4 carriers based on sanger sequencing. The association of ApoE ε4 gene polymorphism, serum UA level, and LVH, determined by cardiac color Doppler ultrasound, was evaluated by multivariate analysis.

Results

A total of 989 CHD patients who underwent ApoE genotyping were enrolled and analyzed. Among them, the frequency of the ApoE ε4 genotype was 17.9% (15.7% for E3/4, 1.1% for E4/4, and 1.1% for E2/4). There were 159 patients with LVH, 262 with end-diastolic LV internal diameter (LVEDD) enlargement, 160 with left ventricular ejection fraction (LVEF) reduction, and 154 with heart failure. Multivariate analysis showed that for every increase of 10 μmol/L in serum UA level, the risk of LVH decreased in ε4 carriers (odds ratio (OR) = 0.94, 95% confidence interval (CI): 0.890–0.992, P = 0.025) and increased in non-ε4 carriers (OR = 1.03, 95% CI: 1.005–1.049, P = 0.016). The risk of LVEDD enlargement tended to decrease in ε4 carriers (OR = 0.98, 95% CI: 0.943-1.023, P = 0.391) and increased in non-ε4 carriers (OR = 1.03, 95% CI: 1.009–1.048, P = 0.003). The risk of LVEF reduction was reduced in ε4 carriers (OR = 0.996, 95% CI: 0.949–1.046, P = 0.872) and increased in non-ε4 carriers (OR = 1.02, 95% CI: 0.994–1.037, P = 0.17). The risk of LVEDD enlargement decreased in ε4 carriers (OR = 0.98, 95% CI: 0.931–1.036, P = 0.508) and increased in non-ε4 carriers (OR = 1.02, 95% CI: 0.998–1.042, P = 0.07).

Conclusion

High serum UA levels decreased the risk of LVH in ApoE ε4 carriers with CHD, while increased the risk of LVH in non-ε4 carriers.
Schiff bases complexed with iron and their relation with the life cycle and infection by Schistosoma mansoni
Authors: da Silva Juliana Virginio , Moreira Carla Cristina , Montija Elisandra de Almeida , Feitosa Karina Alves , Correia Ricardo de Oliveira , Domingues Nelson Luis de Campos , Soares Edson Garcia , Allegretti Silmara Marques , Afonso Ana , Anibal Fernanda de Freitas
Published: December 2022

Introduction

The trematode Schistosoma mansoni causes schistosomiasis, and this parasite’s life cycle depends on the mollusk Biomphalaria glabrata. The most effective treatment for infected people is administering a single dose of Praziquantel. However, there are naturally resistant to treatment. This work has developed, considering this parasite’s complex life cycle.

Methods

The synthetics compound were evaluated: i) during the infection of B. glabrata, ii) during the infection of BALB/c mice, and iii) during the treatment of mice infected with S. mansoni.

Results and Discussion

For the first objective, snails infected with miracidia treated with compounds C1 and C3 at concentrations of 25% IC50 and 50% IC50, after 80 days of infection, released fewer cercariae than the infected group without treatment. For the second objective, compounds C1 and C3 did not show significant results in the infected group without treatment. For the third objective, the mice treated with C3 and C1 reduced the global and differential cell count. The results suggest that although the evaluated compounds do not present schistosomicidal properties when placed in cercariae suspension, they can stimulate an immune reaction in snails and decrease mice’s inflammatory response. In general, we can conclude that compound C1 and C3 has an anti-schistosomicidal effect both in the larval phase (miracidia) and in the adult form of the parasite.
Polo-like kinase 1 is related with malignant characteristics and inhibits macrophages infiltration in glioma
Authors: Luo Lin , Zhang Xiao-Yang , Zhen Ying-Wei , Guo Gao-Chao , Peng Da-Zhao , Wei Cheng , Pei Dong-Ling , Yu Bin , Ji Yu-Chen , Liu Xian-Zhi , Han Lei , Zhang Zhen-Yu
Published: December 2022

Background

Tumor immune microenvironment (TIM) plays a critical role in tumorigenesis and progression. Recently, therapies based on modulating TIM have made great breakthroughs in cancer treatment. Polo-like kinase 1 (PLK1) is a crucial regulatory factor of the cell cycle process and its dysregulations often cause various pathological processes including tumorigenesis. However, the detailed mechanisms surrounding the regulation of PLK1 on glioma immune microenvironment remain undefined.

Methods

Public databases and online datasets were used to extract data of PLK1 expression, clinical features, genetic alterations, and biological functions. The EdU, flow cytometry, and macrophage infiltration assays as well as xenograft animal experiments were performed to determine the relationship between PLK1 and glioma immune microenvironment in vivo and in vitro.

Results

PLK1 is always highly expressed in multiple cancers especially in glioma. Univariable and Multivariate proportional hazard Cox analysis showed that PLK1 was a prognostic biomarker for glioma. Simultaneously, highly expressed PLK1 is significantly related to prognosis, histological and genetic features in glioma by analyzing public databases. In addition, the enrichment analysis suggested that PLK1 might related to “immune response”, “cell cycle”, “DNA replication”, and “mismatch repair” in glioma. Immune infiltration analysis demonstrated that highly expressed PLK1 inhibited M1 macrophages infiltration to glioblastoma immune microenvironment by Quantiseq and Xcell databases and negatively related to some chemokines and marker genes of M1 macrophages in glioblastoma. Subsequent experiments confirmed that PLK1 knockdown inhibited the proliferation of glioma cells but increased the M1 macrophages infiltration and polarization. Furthermore, in glioma xenograft mouse models, we showed that inhibiting PLK1 blocked tumor proliferation and increased the M1 macrophages infiltration. Finally, PLK1 methylation analysis and lncRNA-miRNA network revealed the potential mechanism of abnormal PLK1 expression in glioma.

Conclusions

PLK1 inhibits M1 macrophages infiltration into glioma immune microenvironment and is a potential biomarker for glioma.
Fatal aspergillosis and evidence of unrelated hearing loss in a harbor porpoise (Phocoena phocoena) from the German Baltic Sea
Authors: Rohner Simon , Morell Maria , Wohlsein Peter , Stürznickel Julian , Reiter Eva B. , Jahnke Annika , Prenger-Berninghoff Ellen , Ewers Christa , Walther Grit , Striewe Lotte C. , Failla Antonio Virgilio , Siebert Ursula
Published: December 2022

Detailed post-mortem investigations including the auditory pathway are needed to advance our understanding of how underwater noise and other stressors affect hearing in cetaceans. A 12-year-old female porpoise (Phocoena phocoena) stranded alive in June 2021 at the German Baltic Sea coast and died some hours later. The most significant pathological findings were lesions caused by a severe aspergillosis that spread from the lung and pulmonary lymph node to the cerebellum. Based on molecular sequencing, the fungus was identified asAspergillus fumigatus.Severe pyogranulomatous and necrotizing inflammation was diagnosed in the lung and the associated lymph node. In the left part of the cerebellum, focal, severe purulent and necrotizing meningoencephalitis with intralesional fungal structures was confirmed histologically. In addition, multifocal, severe, chronic, granulomatous, and eosinophilic gastritis with intralesional parasite structures was found in the stomach. Parallel stripes (linear skin markings) were detected along the caudal part of both body sides, which have not been previously described for harbor porpoises. Inner ear analysis revealed evidence of focal loss of outer hair cells in several regions from 120 to 580 µm from the apex of the right cochlea using immunofluorescence. The evidence of low-frequency hearing impairment was compatible with noise-induced hearing loss. This is the first case of concurrent presumptive noise-induced hearing loss and unrelated aspergillosis in a free-ranging harbor porpoise.
Using enactive robotics to think outside of the problem-solving box: How sensorimotor contingencies constrain the forms of emergent autononomous habits
Authors: Egbert Matthew D. , Barandiaran Xabier E.
Published: December 2022

We suggest that the influence of biology in ‘biologically inspired robotics’ can be embraced at a deeper level than is typical, if we adopt an enactive approach that moves the focus of interest from how problems are solved to how problems emerge in the first place. In addition to being inspired by mechanisms found in natural systems or by evolutionary design principles directed at solving problems posited by the environment, we can take inspiration from the precarious, self-maintaining organization of living systems to investigate forms of cognition that are also precarious and self-maintaining and that thus also, like life, have their own problems that must be be addressed if they are to persist. In this vein, we use a simulation to explore precarious, self-reinforcing sensorimotor habits as a building block for a robot's behavior. Our simulations of simple robots controlled by an Iterative Deformable Sensorimotor Medium demonstrate the spontaneous emergence of different habits, their re-enactment and the organization of an ecology of habits within each agent. The form of the emergent habits is constrained by the sensory modality of the robot such that habits formed under one modality (vision) are more similar to each other than they are to habits formed under another (audition). We discuss these results in the wider context of: (a) enactive approaches to life and mind, (b) sensorimotor contingency theory, (c) adaptationist vs. structuralist explanations in biology, and (d) the limits of functionalist problem-solving approaches to (artificial) intelligence.
Efficacy of interoceptive and embodied rehabilitative training protocol in patients with mild multiple sclerosis: A randomized controlled trial
Authors: Paolucci Teresa , de Sire Alessandro , Agostini Francesco , Bernetti Andrea , Salomè Angela , Altieri Marta , Di Piero Vittorio , Ammendolia Antonio , Mangone Massimiliano , Paoloni Marco
Published: December 2022

Introduction

The aim of this randomized controlled trial was to evaluate the effect of an embodied rehabilitative protocol, in improving interoceptive awareness respect balance and motor performance in patients with mild multiple sclerosis (pwMS).

Methods

In this study patients with relapsing-remitting multiple sclerosis were enrolled. The rehabilitative treatment group (TG) participated in an embodied physiotherapy program consisting of 8 one-hour sessions in groups of 4 patients at a time, 1 per week and 2 one-hour sessions of neuro-cognitive exercise in single session during the rehabilitation program. All pwMS underwent a clinical assessment to measure the interoception sense for the Multidimensional Assessment of Interoceptive Awareness scale, balance for the Tinetti Mobility test and stabilometry, quality of life for the Short Form Health Survey-12 and body image perception for Trunk Appearance Perception Scale and Body Image Scale. All previous scales and tests were performed at baseline (T0), at the end of treatment (T1) and after 2 months of follow up (T2).

Results

Sixty patients were enrolled and randomized into two groups: TG (n = 30), aged 43.0 ± 10.2 years, and a control/waiting list (WLG) group (n = 30), aged 40.7 ± 10.4 years. Statistically significant improvements in interoceptive awareness, body image perception, balance and quality of life were reported in TG versus WLG (p < 0.05).

Discussion

This study suggests that enhancing interoceptive awareness could improve postural balance. Future studies with a larger sample of patients will be needed to better quantify the effects of an embodied rehabilitation.
Advances in P300 brain–computer interface spellers: toward paradigm design and performance evaluation
Authors: Pan Jiahui , Chen XueNing , Ban Nianming , He JiaShao , Chen Jiayi , Huang Haiyun
Published: December 2022

A brain-computer interface (BCI) is a non-muscular communication technology that provides an information exchange channel for our brains and external devices. During the decades, BCI has made noticeable progress and has been applied in many fields. One of the most traditional BCI applications is the BCI speller. This article primarily discusses the progress of research into P300 BCI spellers and reviews four types of P300 spellers: single-modal P300 spellers, P300 spellers based on multiple brain patterns, P300 spellers with multisensory stimuli, and P300 spellers with multiple intelligent techniques. For each type of P300 speller, we further review several representative P300 spellers, including their design principles, paradigms, algorithms, experimental performance, and corresponding advantages. We particularly emphasized the paradigm design ideas, including the overall layout, individual symbol shapes and stimulus forms. Furthermore, several important issues and research guidance for the P300 speller were identified. We hope that this review can assist researchers in learning the new ideas of these novel P300 spellers and enhance their practical application capability.
Transcutaneous spinal stimulation in patients with intrathecal baclofen pump delivery system: A preliminary safety study
Authors: Lopez John , Forrest Gail F. , Engel-Haber Einat , Snider Brittany , Momeni Kam , Ravi Manikandan , Kirshblum Steven
Published: December 2022

Objective

To determine the effect of transcutaneous spinal stimulation (TSS) on an implanted intrathecal baclofen (ITB) pump in persons with traumatic spinal cord injury (SCI).

Design

Prospective clinical trial.

Participants

Five individuals with chronic traumatic SCI, >18 years of age, and an anteriorly implanted Medtronic SynchroMed™ II ITB pump delivery system.

Intervention

Transcutaneous spinal stimulation trials with cathode at T11/12, with pump interrogation before, during and after stimulation.

Results

There was no evidence of any effect of the TSS in regards to disruption of the ITB pump delivery mechanism. Communication interference with the interrogator to the pump occurred often during stimulation for log transmission most likely secondary to the electromagnetic interference from the stimulation. One individual had elevated blood pressure at the end of the trial, suspected to be unrelated to the spinal stimulation.

Conclusion

Based upon this pilot study, further TSS studies including persons with an implanted Medtronic SynchroMed™ II ITB pump can be considered when stimulating at the low thoracic spine, although communication with the programmer during the stimulation may be affected.
Local prothoracic auditory neurons in Ensifera
Authors: Cillov Ali , Stumpner Andreas
Published: December 2022

A new method for individually staining insect neurons with metal ions was described in the late 60s, closely followed by the introduction of the first bright fluorescent dye, Lucifer Yellow, for the same purpose. These milestones enabled an unprecedented level of detail regarding the neuronal basis of sensory processes such as hearing. Due to their conspicuous auditory behavior, orthopterans rapidly established themselves as a popular model for studies on hearing (first identified auditory neuron: 1974; first local auditory interneuron: 1977). Although crickets (Ensifera, Gryllidae) surpassed grasshoppers (Caelifera) as the main model taxon, surprisingly few neuronal elements have been described in crickets. More auditory neurons are described for bush crickets (Ensifera, Tettigoniidae), but due to their great biodiversity, the described auditory neurons in bush crickets are scattered over distantly related groups, hence being confounded by potential differences in the neuronal pathways themselves. Our review will outline all local auditory elements described in ensiferans so far. We will focus on one bush cricket species, Ancistrura nigrovittata (Phaneropterinae), which has the so-far highest diversity of identified auditory interneurons within Ensifera. We will present one novel and three previously described local prothoracic auditory neuron classes, comparing their morphology and aspects of sensory processing. Finally, we will hypothesize about their functions and evolutionary connections between ensiferan insects.
Retinal degeneration protein 3 controls membrane guanylate cyclase activities in brain tissue
Authors: Chen Yaoyu , Bräuer Anja U. , Koch Karl-Wilhelm
Published: December 2022

The retinal degeneration protein RD3 is involved in regulatory processes of photoreceptor cells. Among its main functions is the inhibition of photoreceptor specific membrane guanylate cyclases during trafficking from the inner segment to their final destination in the outer segment. However, any physiological role of RD3 in non-retinal tissue is unsolved at present and specific protein targets outside of retinal tissue have not been identified so far. The family of membrane bound guanylate cyclases share a high homology of their amino acid sequences in their cytoplasmic domains. Therefore, we reasoned that membrane guanylate cyclases that are activated by natriuretic peptides are also regulated by RD3. We analyzed transcript levels of the rd3 gene and natriuretic peptide receptor genes Npr1 and Npr2 in the mouse retina, cerebellum, hippocampus, neocortex, and the olfactory bulb during development from the embryonic to the postnatal stage at P60. The rd3 gene showed a lower expression level than Npr1 and Npr2 (encoding for GC-A and GC-B, respectively) in all tested brain tissues, but was at least one order of magnitude higher in the retina. RD3 and natriuretic peptide receptor GCs co-express in the retina and brain tissue leading to functional tests. We expressed GC-A and GC-B in HEK293T cells and measured the inhibition of GCs by RD3 after activation by natriuretic peptides yielding inhibitory constants around 25 nM. Furthermore, endogenous GCs in astrocytes were inhibited by RD3 to a similar extent. We here show for the first time that RD3 can inhibit two hormone-stimulated GCs, namely GC-A and GC-B indicating a new regulatory feature of these hormone receptors.
Improved detection of coronary artery disease by CZT regional coronary blood flow evaluation
Authors: Lima R. S. L. , Bezerra A. , Andrade M. , Domenico C. , De Lorenzo A.
Published: December 2022

Introduction

CZT cameras have enabled the noninvasive quantification of myocardial flow reserve (MFR), an important physiologic measure. This study aimed to compare myocardial perfusion SPECT (MPS) with or without MFR evaluation for the detection of obstructive coronary artery disease (CAD).

Methods

48 patients with CAD (>50% obstruction) detected at invasive coronary angiography or CT angiography underwent dipyridamole MPS and MFR evaluation within 30 days. A 1-day protocol (rest-stress) was used to quantify MFR. The acquisition of dynamic rest and stress images was initiated simultaneously to 99mTc sestamibi injection (370 and 1,110 MBq, respectively), both lasting for 11 min, followed by 5-min imaging. Pharmacologic stress with dipyridamole (0.56 mg/kg for 4 min) was performed with the patient positioned in the CZT camera. The images were processed and time-activity curves were generated, calculating global and regional MFR in a semiautomatic software. A global or regional MFR <2 was considered abnormal. MPS perfusion images were classified as normal or abnormal. The images were interpreted by experienced physicians blinded to the results of MFR and coronary angiography/CT.

Results

Mean age of the population was 61 ± 9 years, 54.2% female. Twenty patients (41.7%) had single-vessel CAD, 22 (45.8%) 2-vessel CAD and 6 (12.5%), triple-vessel CAD. Among the 82 vessels with obstruction, 48 had perfusion abnormalities in MPS and 60 had reduced MFR, while among the normal vessels, had 54 normal MPS and 52 had preserved MFR. The sensitivity of MFR (69%) was higher than that of MPS (55.2%), without significant changes in specificity (86 vs. 83.7%).

Conclusions

MFR in the CZT camera is more sensitive for the detection of CAD than perfusion abnormalities in MPS, especially in patients with multivessel CAD.